From e73253c0cd43cba910df73480b5c907a4438c71e Mon Sep 17 00:00:00 2001 From: Wambaugh Date: Wed, 10 Jan 2024 14:19:35 -0500 Subject: [PATCH 1/9] Loading all QSARs introduces duplicates --- scripts/httk-for-dashboard.R | 63 +++++++++++++++++++++++++++++++++--- 1 file changed, 58 insertions(+), 5 deletions(-) diff --git a/scripts/httk-for-dashboard.R b/scripts/httk-for-dashboard.R index fe58ebef..f203b72d 100644 --- a/scripts/httk-for-dashboard.R +++ b/scripts/httk-for-dashboard.R @@ -43,6 +43,42 @@ load_pradeep2020() # Caco-2 QSPR: load_honda2023() +# Find all the duplicates: +chem.physical_and_invitro.data <- subset(chem.physical_and_invitro.data, + !is.na(DTXSID)) +dup.chems <- chem.physical_and_invitro.data$DTXSID[duplicated((chem.physical_and_invitro.data$DTXSID))] +length(dup.chems) +dup.chems <- unique(dup.chems, + subset(chem.physical_and_invitro.data, CAS %in% + chem.physical_and_invitro.data$CAS[ + duplicated((chem.physical_and_invitro.data$CAS))])$DTXSID) +length(dup.chems) + +# Try to keep predictions from Dawson 2021: +for (this.chem in dup.chems) +{ + these.dup.rows <- which(chem.physical_and_invitro.data$DTXSID==this.chem) + keep.row <- NULL + for(this.row in these.dup.rows) + if (regexpr("Dawson", + chem.physical_and_invitro.data[this.row,"Human.Clint.Reference"])!=-1 + ) keep.row <- this.row + these.dup.rows <- these.dup.rows[these.dup.rows!=keep.row] + chem.physical_and_invitro.data <- chem.physical_and_invitro.data[ + -these.dup.rows,] +} + +# Check to make sure no duplicates left: +chem.physical_and_invitro.data <- subset(chem.physical_and_invitro.data, + !is.na(DTXSID)) +dup.chems <- chem.physical_and_invitro.data$DTXSID[duplicated((chem.physical_and_invitro.data$DTXSID))] +length(dup.chems) +dup.chems <- unique(dup.chems, + subset(chem.physical_and_invitro.data, CAS %in% + chem.physical_and_invitro.data$CAS[ + duplicated((chem.physical_and_invitro.data$CAS))])$DTXSID) +length(dup.chems) + # Organize HTTK data by species: HTTK.data.list <- list() all.ids <- NULL @@ -62,10 +98,10 @@ for (this.species in SPECIES.LIST) all.ids <- sort(unique(c(all.ids,HTTK.data.list[[this.species]]$DTXSID))) } -# temporilay make it run fast: -ivpkfit <- read.csv("invivoPKfit-params.for.dashboard.txt") -short.list <- ivpkfit$Chemical[1:25] -all.ids <- all.ids[all.ids %in% short.list] +# temporarily make it run fast: +#ivpkfit <- read.csv("invivoPKfit-params.for.dashboard.txt") +#short.list <- ivpkfit$Chemical[1:25] +#all.ids <- all.ids[all.ids %in% short.list] # We want one parameter per line, but the code is pretty different wrt how we @@ -261,8 +297,25 @@ clusterExport(cl, c( "WHICH.QUANTILES", "NUM.SAMPLES")) +dashboard.list <- NULL +for (this.id in all.ids) + dashboard.list[[this.id]] <- make.ccd.table( + this.id=this.id, + HTTK.data.list=HTTK.data.list, + species.list=SPECIES.LIST, + model.list=MODELS.LIST, + param.list=param.list, + units.list=units.list, + all.ids=all.ids, + RANDOM.SEED=RANDOM.SEED, + which.quantiles=WHICH.QUANTILES, + num.samples=NUM.SAMPLES + ) + # Create a list with one table per chemical: -dashboard.list <- clusterApply(cl,all.ids,function(x) +dashboard.list <- clusterApply(cl, + all.ids, + function(x) make.ccd.table( this.id=x, HTTK.data.list=HTTK.data.list, From ce1c0099fbcdd9282c99d4dca3c8f1389ce2b2eb Mon Sep 17 00:00:00 2001 From: Wambaugh Date: Sun, 14 Jan 2024 19:15:37 -0500 Subject: [PATCH 2/9] Finished running all chemicals --- .../Dashboard-HTTK-CssunitsmgpL-change.txt | 15763 +- scripts/Dashboard-HTTK-CssunitsmgpL.txt | 244529 ++++++++------- scripts/Dashboard-HTTK-stamp.RData | Bin 142 -> 141 bytes scripts/calc-mc-css-fold-change.png | Bin 5219 -> 5630 bytes scripts/httk-for-dashboard.R | 49 +- 5 files changed, 136610 insertions(+), 123731 deletions(-) diff --git a/scripts/Dashboard-HTTK-CssunitsmgpL-change.txt b/scripts/Dashboard-HTTK-CssunitsmgpL-change.txt index 450a8f84..8536a4fc 100644 --- a/scripts/Dashboard-HTTK-CssunitsmgpL-change.txt +++ b/scripts/Dashboard-HTTK-CssunitsmgpL-change.txt @@ -1,7548 +1,8217 @@ DTXSID Parameter Model Species Percentile Predicted.prev Units.prev Predicted.new Units.new Change -DTXSID0020020 Css 3compartmentss Human 95% 4.348 mg/L 2.459 mg/L 1.76819845465636 -DTXSID0020022 Css 3compartmentss Human 95% 185.6 mg/L 117.1 mg/L 1.58497011101623 -DTXSID0020070 Css 3compartmentss Human 95% 1.688 mg/L 0.9712 mg/L 1.73805601317957 -DTXSID0020072 Css 3compartmentss Human 95% 4.993 mg/L 2.892 mg/L 1.72648686030429 -DTXSID0020074 Css 3compartmentss Human 95% 3.01 mg/L 2.064 mg/L 1.45833333333333 -DTXSID0020076 Css 3compartmentss Human 95% 2.033 mg/L 1.231 mg/L 1.6515028432169 -DTXSID0020101 Css 3compartmentss Human 95% 341.2 mg/L 9.45e-05 mg/L 3610582.01058201 -DTXSID0020103 Css 3compartmentss Human 95% 5.684 mg/L 3.309 mg/L 1.71773949833787 -DTXSID0020105 Css 3compartmentss Human 95% 6.477 mg/L 3.964 mg/L 1.63395560040363 -DTXSID0020107 Css 3compartmentss Human 95% 5.343 mg/L 2.503 mg/L 2.13463843387934 -DTXSID0020151 Css 3compartmentss Human 95% 1.136 mg/L 0.7824 mg/L 1.4519427402863 -DTXSID0020157 Css 3compartmentss Human 95% 1.392 mg/L 0.9431 mg/L 1.47598345880606 -DTXSID0020232 Css 3compartmentss Human 95% 1.325 mg/L 1.092 mg/L 1.21336996336996 -DTXSID0020236 Css 3compartmentss Human 95% 7.454 mg/L 4.649 mg/L 1.60335556033556 -DTXSID0020238 Css 3compartmentss Human 95% 0.628 mg/L 0.4314 mg/L 1.45572554473806 -DTXSID0020280 Css 3compartmentss Human 95% 1.704 mg/L 1.193 mg/L 1.42833193629505 -DTXSID0020282 Css 3compartmentss Human 95% 3.049 mg/L 1.893 mg/L 1.61067089276281 -DTXSID0020284 Css 3compartmentss Human 95% 1.463 mg/L 0.9214 mg/L 1.58780117212937 -DTXSID0020286 Css 3compartmentss Human 95% 0.3215 mg/L 0.1873 mg/L 1.71649759743727 -DTXSID0020288 Css 3compartmentss Human 95% 0.7942 mg/L 0.5054 mg/L 1.57142857142857 -DTXSID0020311 Css 3compartmentss Human 95% 1.851 mg/L 1.256 mg/L 1.47372611464968 -DTXSID0020319 Css 3compartmentss Human 95% 20.22 mg/L 13.76 mg/L 1.46947674418605 -DTXSID0020361 Css 3compartmentss Human 95% 2.085 mg/L 1.363 mg/L 1.52971386647102 -DTXSID0020363 Css 3compartmentss Human 95% 5.473 mg/L 3.782 mg/L 1.44711792702274 -DTXSID0020367 Css 3compartmentss Human 95% 5.742 mg/L 3.704 mg/L 1.55021598272138 -DTXSID0020369 Css 3compartmentss Human 95% 1.043 mg/L 0.4921 mg/L 2.11948790896159 -DTXSID0020440 Css 3compartmentss Human 95% 796.2 mg/L 461.8 mg/L 1.72412299696838 -DTXSID0020442 Css 3compartmentss Human 95% 112.3 mg/L 95.4 mg/L 1.17714884696017 -DTXSID0020444 Css 3compartmentss Human 95% 53 mg/L 0.002144 mg/L 24720.1492537313 -DTXSID0020446 Css 3compartmentss Human 95% 2.073 mg/L 1.674 mg/L 1.23835125448029 -DTXSID0020494 Css 3compartmentss Human 95% 5.966 mg/L 3.788 mg/L 1.57497360084477 -DTXSID0020498 Css 3compartmentss Human 95% 0.02998 mg/L 0.01897 mg/L 1.58039008961518 -DTXSID0020523 Css 3compartmentss Human 95% 235.9 mg/L 137.7 mg/L 1.71314451706609 -DTXSID0020527 Css 3compartmentss Human 95% 4.982 mg/L 3.462 mg/L 1.43905257076834 -DTXSID0020529 Css 3compartmentss Human 95% 50.09 mg/L 30.86 mg/L 1.62313674659754 -DTXSID0020573 Css 3compartmentss Human 95% 9.146 mg/L 2.952 mg/L 3.09823848238482 -DTXSID0020575 Css 3compartmentss Human 95% 0.974 mg/L 0.8407 mg/L 1.15855834423695 -DTXSID0020577 Css 3compartmentss Human 95% 4.509 mg/L 2.782 mg/L 1.62077641984184 -DTXSID0020602 Css 3compartmentss Human 95% 3.201 mg/L 2.112 mg/L 1.515625 -DTXSID0020604 Css 3compartmentss Human 95% 0.07548 mg/L 0.05185 mg/L 1.45573770491803 -DTXSID0020606 Css 3compartmentss Human 95% 16.33 mg/L 3.854e-05 mg/L 423715.620134925 -DTXSID0020650 Css 3compartmentss Human 95% 11.02 mg/L 6.852 mg/L 1.60828955049621 -DTXSID0020652 Css 3compartmentss Human 95% 4.393 mg/L 1.976 mg/L 2.22317813765182 -DTXSID0020656 Css 3compartmentss Human 95% 12.6 mg/L 7.504 mg/L 1.67910447761194 -DTXSID0020733 Css 3compartmentss Human 95% 0.2555 mg/L 0.1539 mg/L 1.6601689408707 -DTXSID0020737 Css 3compartmentss Human 95% 3.324 mg/L 2.23 mg/L 1.49058295964126 -DTXSID0020785 Css 3compartmentss Human 95% 0.3467 mg/L 0.2922 mg/L 1.18651608487337 -DTXSID0020789 Css 3compartmentss Human 95% 6.815 mg/L 4.681 mg/L 1.45588549455245 -DTXSID0020810 Css 3compartmentss Human 95% 0.8611 mg/L 0.6075 mg/L 1.41744855967078 -DTXSID0020814 Css 3compartmentss Human 95% 12.7 mg/L 3.043 mg/L 4.17351298061124 -DTXSID0020818 Css 3compartmentss Human 95% 1.121 mg/L 0.8263 mg/L 1.35665012707249 -DTXSID0020941 Css 3compartmentss Human 95% 10.97 mg/L 6.711 mg/L 1.63462971241246 -DTXSID0020943 Css 3compartmentss Human 95% 0.7718 mg/L 0.4754 mg/L 1.62347496844762 -DTXSID0021040 Css 3compartmentss Human 95% 2.466 mg/L 1.739 mg/L 1.41805635422657 -DTXSID0021094 Css 3compartmentss Human 95% 9.251 mg/L 6.232 mg/L 1.4844351732991 -DTXSID0021096 Css 3compartmentss Human 95% 1.846 mg/L 1.143 mg/L 1.61504811898513 -DTXSID0021121 Css 3compartmentss Human 95% 0.3258 mg/L 0.1301 mg/L 2.50422751729439 -DTXSID0021123 Css 3compartmentss Human 95% 9.418 mg/L 5.815 mg/L 1.61960447119518 -DTXSID0021125 Css 3compartmentss Human 95% 4.251 mg/L 1.788 mg/L 2.37751677852349 -DTXSID0021127 Css 3compartmentss Human 95% 4.96 mg/L 1.123 mg/L 4.41674087266251 -DTXSID0021129 Css 3compartmentss Human 95% 8.988 mg/L 9.194 mg/L 0.977594083097672 -DTXSID0021175 Css 3compartmentss Human 95% 3091 mg/L 5861 mg/L 0.527384405391571 -DTXSID0021179 Css 3compartmentss Human 95% 0.2228 mg/L 0.2348 mg/L 0.948892674616695 -DTXSID0021206 Css 3compartmentss Human 95% 5.697 mg/L 3.651 mg/L 1.56039441248973 -DTXSID0021256 Css 3compartmentss Human 95% 186.9 mg/L 100.2 mg/L 1.86526946107784 -DTXSID0021258 Css 3compartmentss Human 95% 0.2997 mg/L 0.1838 mg/L 1.63057671381937 -DTXSID0021331 Css 3compartmentss Human 95% 3.217 mg/L 2.299 mg/L 1.39930404523706 -DTXSID0021333 Css 3compartmentss Human 95% 0.2032 mg/L 0.1487 mg/L 1.36650975117687 -DTXSID0021335 Css 3compartmentss Human 95% 1.206 mg/L 0.9009 mg/L 1.33866133866134 -DTXSID0021337 Css 3compartmentss Human 95% 35.55 mg/L 27.77 mg/L 1.28015844436442 -DTXSID0021339 Css 3compartmentss Human 95% 3.271 mg/L 3.37 mg/L 0.970623145400593 -DTXSID0021387 Css 3compartmentss Human 95% 534.4 mg/L 307.4 mg/L 1.7384515289525 -DTXSID0021389 Css 3compartmentss Human 95% 0.1488 mg/L 0.1051 mg/L 1.41579448144624 -DTXSID0021410 Css 3compartmentss Human 95% 1.881 mg/L 0.6287 mg/L 2.99188802290441 -DTXSID0021414 Css 3compartmentss Human 95% 0.005682 mg/L 0 mg/L Inf -DTXSID0021418 Css 3compartmentss Human 95% 4.772 mg/L 1.948 mg/L 2.44969199178645 -DTXSID0021460 Css 3compartmentss Human 95% 0.8008 mg/L 0.5655 mg/L 1.41609195402299 -DTXSID0021462 Css 3compartmentss Human 95% 4.098 mg/L 2.546 mg/L 1.60958366064415 -DTXSID0021464 Css 3compartmentss Human 95% 7.333 mg/L 4.489 mg/L 1.63354867453776 -DTXSID0021545 Css 3compartmentss Human 95% 7.203 mg/L 4.59 mg/L 1.56928104575163 -DTXSID0021547 Css 3compartmentss Human 95% 4.944 mg/L 2.304 mg/L 2.14583333333333 -DTXSID0021620 Css 3compartmentss Human 95% 3.045 mg/L 3.615 mg/L 0.842323651452282 -DTXSID0021626 Css 3compartmentss Human 95% 2.163 mg/L 2.081 mg/L 1.03940413262854 -DTXSID0021628 Css 3compartmentss Human 95% 6.393 mg/L 4.084 mg/L 1.56537708129285 -DTXSID0021709 Css 3compartmentss Human 95% 1.365 mg/L 1.356 mg/L 1.00663716814159 -DTXSID0021751 Css 3compartmentss Human 95% 7.664 mg/L 4.851 mg/L 1.57988043702329 -DTXSID0021757 Css 3compartmentss Human 95% 0.8557 mg/L 0.5654 mg/L 1.51344181110718 -DTXSID0021759 Css 3compartmentss Human 95% 5.626 mg/L 3.84 mg/L 1.46510416666667 -DTXSID0021834 Css 3compartmentss Human 95% 1.486 mg/L 0.8775 mg/L 1.69344729344729 -DTXSID0021836 Css 3compartmentss Human 95% 7.573 mg/L 5.18 mg/L 1.46196911196911 -DTXSID0021915 Css 3compartmentss Human 95% 4.548 mg/L 1.98 mg/L 2.2969696969697 -DTXSID0021961 Css 3compartmentss Human 95% 7.469 mg/L 5.181 mg/L 1.4416135881104 -DTXSID0021969 Css 3compartmentss Human 95% 0.03877 mg/L 0.02531 mg/L 1.53180561043066 -DTXSID0022010 Css 3compartmentss Human 95% 1801 mg/L 9739 mg/L 0.184926583838176 -DTXSID0022012 Css 3compartmentss Human 95% 0.1986 mg/L 0.1161 mg/L 1.71059431524548 -DTXSID0022014 Css 3compartmentss Human 95% 0.02784 mg/L 0.01862 mg/L 1.49516648764769 -DTXSID0022016 Css 3compartmentss Human 95% 0.6631 mg/L 0.4667 mg/L 1.42082708377973 -DTXSID0022060 Css 3compartmentss Human 95% 0.4487 mg/L 0.2745 mg/L 1.63460837887067 -DTXSID00220983 Css 3compartmentss Human 95% 1.062 mg/L 0.5611 mg/L 1.89271074674746 -DTXSID0022220 Css 3compartmentss Human 95% 1068 mg/L 737.8 mg/L 1.44754676063974 -DTXSID0022301 Css 3compartmentss Human 95% 2.062 mg/L 0.0002401 mg/L 8588.08829654311 -DTXSID0022307 Css 3compartmentss Human 95% 6.59 mg/L 5.096 mg/L 1.29317111459969 -DTXSID0022353 Css 3compartmentss Human 95% 105.1 mg/L 36.95 mg/L 2.84438430311231 -DTXSID0022432 Css 3compartmentss Human 95% 4.937 mg/L 0.005511 mg/L 895.844674287788 -DTXSID0022436 Css 3compartmentss Human 95% 14.13 mg/L 9.168 mg/L 1.54123036649215 -DTXSID0022480 Css 3compartmentss Human 95% 1.418 mg/L 0.7879 mg/L 1.79972077674832 -DTXSID0022563 Css 3compartmentss Human 95% 5.729 mg/L 3.134 mg/L 1.82801531589024 -DTXSID0022565 Css 3compartmentss Human 95% 0.9485 mg/L 0.5681 mg/L 1.66960042246083 -DTXSID0022569 Css 3compartmentss Human 95% 0.1128 mg/L 0 mg/L Inf -DTXSID0022640 Css 3compartmentss Human 95% 7.99 mg/L 5.047 mg/L 1.58311868436695 -DTXSID0022644 Css 3compartmentss Human 95% 2.182 mg/L 1.104 mg/L 1.97644927536232 -DTXSID0022646 Css 3compartmentss Human 95% 0.5756 mg/L 0.01634 mg/L 35.2264381884945 -DTXSID0022690 Css 3compartmentss Human 95% 3.125 mg/L 0.9883 mg/L 3.16199534554285 -DTXSID0022692 Css 3compartmentss Human 95% 12.98 mg/L 7.291 mg/L 1.78027705390207 -DTXSID0022721 Css 3compartmentss Human 95% 0.1195 mg/L 0 mg/L Inf -DTXSID0022725 Css 3compartmentss Human 95% 285.3 mg/L 149.9 mg/L 1.90326884589726 -DTXSID0022727 Css 3compartmentss Human 95% 0.007759 mg/L 0 mg/L Inf -DTXSID0022777 Css 3compartmentss Human 95% 20.44 mg/L 5.465 mg/L 3.74016468435499 -DTXSID0022800 Css 3compartmentss Human 95% 6.983 mg/L 3.973 mg/L 1.75761389378304 -DTXSID0022804 Css 3compartmentss Human 95% 0.7231 mg/L 0.341 mg/L 2.12052785923754 -DTXSID0022808 Css 3compartmentss Human 95% 2.232 mg/L 0.01387 mg/L 160.922855082913 -DTXSID0022850 Css 3compartmentss Human 95% 0.3605 mg/L 0.2668 mg/L 1.35119940029985 -DTXSID0022854 Css 3compartmentss Human 95% 7.15 mg/L 3.16 mg/L 2.2626582278481 -DTXSID0022858 Css 3compartmentss Human 95% 0.3765 mg/L 0.228 mg/L 1.65131578947368 -DTXSID0022933 Css 3compartmentss Human 95% 0.03784 mg/L 0.01935 mg/L 1.95555555555556 -DTXSID0022935 Css 3compartmentss Human 95% 0.5652 mg/L 0.3953 mg/L 1.42980015178346 -DTXSID0022981 Css 3compartmentss Human 95% 1.337 mg/L 0.7892 mg/L 1.69412062848454 -DTXSID0023030 Css 3compartmentss Human 95% 11.28 mg/L 6.096 mg/L 1.8503937007874 -DTXSID0023032 Css 3compartmentss Human 95% 23.31 mg/L 12.2 mg/L 1.91065573770492 -DTXSID0023036 Css 3compartmentss Human 95% 0.7751 mg/L 0.0001033 mg/L 7503.38818973863 -DTXSID0023038 Css 3compartmentss Human 95% 0.761 mg/L 0.4654 mg/L 1.63515255694027 -DTXSID0023084 Css 3compartmentss Human 95% 0.3012 mg/L 0.2266 mg/L 1.32921447484554 -DTXSID0023088 Css 3compartmentss Human 95% 5.669 mg/L 3.628 mg/L 1.56256890848953 -DTXSID0023111 Css 3compartmentss Human 95% 1.1 mg/L 0.6478 mg/L 1.6980549552331 -DTXSID0023113 Css 3compartmentss Human 95% 0.09773 mg/L 0.07156 mg/L 1.36570709893795 -DTXSID0023163 Css 3compartmentss Human 95% 5.071 mg/L 3.278 mg/L 1.54697986577181 -DTXSID0023169 Css 3compartmentss Human 95% 3.717 mg/L 2.207 mg/L 1.68418667874943 -DTXSID0023244 Css 3compartmentss Human 95% 2.638 mg/L 1.656 mg/L 1.59299516908213 -DTXSID0023292 Css 3compartmentss Human 95% 0.1297 mg/L 0.09405 mg/L 1.37905369484317 -DTXSID0023294 Css 3compartmentss Human 95% 0.05214 mg/L 0.03071 mg/L 1.69781830022794 -DTXSID0023296 Css 3compartmentss Human 95% 3.959 mg/L 1.651 mg/L 2.39794064203513 -DTXSID0023298 Css 3compartmentss Human 95% 0.896 mg/L 0.9053 mg/L 0.989727162266652 -DTXSID00233139 Css 3compartmentss Human 95% 20.4 mg/L 6.003 mg/L 3.39830084957521 -DTXSID0023321 Css 3compartmentss Human 95% 1.779 mg/L 1.332 mg/L 1.33558558558559 -DTXSID0023323 Css 3compartmentss Human 95% 5.293 mg/L 3.628 mg/L 1.45893054024256 -DTXSID0023325 Css 3compartmentss Human 95% 5.914 mg/L 3.423 mg/L 1.72772421852176 -DTXSID0023329 Css 3compartmentss Human 95% 0.5186 mg/L 0.3442 mg/L 1.50668216153399 -DTXSID0023371 Css 3compartmentss Human 95% 1849 mg/L 1054 mg/L 1.75426944971537 -DTXSID0023373 Css 3compartmentss Human 95% 22.21 mg/L 9.884 mg/L 2.24706596519628 -DTXSID0023377 Css 3compartmentss Human 95% 1.197 mg/L 1.207 mg/L 0.991714995857498 -DTXSID0023458 Css 3compartmentss Human 95% 4.96 mg/L 1.123 mg/L 4.41674087266251 -DTXSID0023533 Css 3compartmentss Human 95% 0.3841 mg/L 0.2367 mg/L 1.6227291930714 -DTXSID0023581 Css 3compartmentss Human 95% 14.63 mg/L 0.5346 mg/L 27.3662551440329 -DTXSID0023587 Css 3compartmentss Human 95% 2.826 mg/L 1.806 mg/L 1.56478405315615 -DTXSID0023589 Css 3compartmentss Human 95% 7.244 mg/L 5.003 mg/L 1.44793124125525 -DTXSID0023612 Css 3compartmentss Human 95% 3.93 mg/L 2.188 mg/L 1.79616087751371 -DTXSID0023616 Css 3compartmentss Human 95% 3.501 mg/L 1.931 mg/L 1.81305023303988 -DTXSID0023618 Css 3compartmentss Human 95% 150.4 mg/L 76.8 mg/L 1.95833333333333 -DTXSID0023660 Css 3compartmentss Human 95% 5.073 mg/L 2.86 mg/L 1.77377622377622 -DTXSID0023743 Css 3compartmentss Human 95% 2.313 mg/L 2.437 mg/L 0.94911776774723 -DTXSID0023745 Css 3compartmentss Human 95% 5.573 mg/L 3.628 mg/L 1.53610804851158 -DTXSID0023747 Css 3compartmentss Human 95% 0.5126 mg/L 0.3948 mg/L 1.2983789260385 -DTXSID0023749 Css 3compartmentss Human 95% 0.161 mg/L 0.09819 mg/L 1.6396781749669 -DTXSID0023826 Css 3compartmentss Human 95% 0.9834 mg/L 0.6401 mg/L 1.53632244961725 -DTXSID0023870 Css 3compartmentss Human 95% 2.027 mg/L 1.322 mg/L 1.53328290468986 -DTXSID0023901 Css 3compartmentss Human 95% 300.5 mg/L 182.6 mg/L 1.64567360350493 -DTXSID0023907 Css 3compartmentss Human 95% 4.446 mg/L 0.1045 mg/L 42.5454545454545 -DTXSID0023909 Css 3compartmentss Human 95% 9.266 mg/L 0.001885 mg/L 4915.64986737401 -DTXSID0023951 Css 3compartmentss Human 95% 0.8648 mg/L 0.6265 mg/L 1.38036711891461 -DTXSID0023955 Css 3compartmentss Human 95% 31.47 mg/L 17.33 mg/L 1.81592613964224 -DTXSID0024000 Css 3compartmentss Human 95% 8.283 mg/L 1.359 mg/L 6.09492273730684 -DTXSID0024002 Css 3compartmentss Human 95% 23.04 mg/L 0.6061 mg/L 38.0135291206072 -DTXSID0024052 Css 3compartmentss Human 95% 2.056 mg/L 1.56 mg/L 1.31794871794872 -DTXSID0024266 Css 3compartmentss Human 95% 4.775 mg/L 1.185 mg/L 4.0295358649789 -DTXSID0024341 Css 3compartmentss Human 95% 1.032 mg/L 0.6815 mg/L 1.51430667644901 -DTXSID0024345 Css 3compartmentss Human 95% 19.29 mg/L 10.25 mg/L 1.8819512195122 -DTXSID0024395 Css 3compartmentss Human 95% 3.084 mg/L 3.335 mg/L 0.924737631184408 -DTXSID0024397 Css 3compartmentss Human 95% 3.148 mg/L 2.088 mg/L 1.50766283524904 -DTXSID0024399 Css 3compartmentss Human 95% 3.127 mg/L 3.232 mg/L 0.967512376237624 -DTXSID0024470 Css 3compartmentss Human 95% 3.687 mg/L 2.517 mg/L 1.46483909415971 -DTXSID0024474 Css 3compartmentss Human 95% 9.735 mg/L 5.892 mg/L 1.65224032586558 -DTXSID0024478 Css 3compartmentss Human 95% 3.793 mg/L 2.394 mg/L 1.5843776106934 -DTXSID0024501 Css 3compartmentss Human 95% 134 mg/L 78.47 mg/L 1.70765897795336 -DTXSID0024503 Css 3compartmentss Human 95% 2.351 mg/L 2.069 mg/L 1.13629772837119 -DTXSID0024505 Css 3compartmentss Human 95% 1.594 mg/L 1.05 mg/L 1.51809523809524 -DTXSID0024507 Css 3compartmentss Human 95% 8.022 mg/L 5.022 mg/L 1.5973715651135 -DTXSID0024509 Css 3compartmentss Human 95% 7.276 mg/L 4.57 mg/L 1.59212253829322 -DTXSID0024553 Css 3compartmentss Human 95% 5.678 mg/L 3.628 mg/L 1.56504961411246 -DTXSID0024555 Css 3compartmentss Human 95% 11.93 mg/L 6.919 mg/L 1.72423760659055 -DTXSID0024559 Css 3compartmentss Human 95% 1.562 mg/L 0.8028 mg/L 1.94569008470354 -DTXSID0024715 Css 3compartmentss Human 95% 9.066 mg/L 5.189 mg/L 1.74715744844864 -DTXSID0024761 Css 3compartmentss Human 95% 1.624 mg/L 1.122 mg/L 1.44741532976827 -DTXSID0024890 Css 3compartmentss Human 95% 2.629 mg/L 2.455 mg/L 1.07087576374745 -DTXSID0024896 Css 3compartmentss Human 95% 31.11 mg/L 17.1 mg/L 1.81929824561403 -DTXSID0024921 Css 3compartmentss Human 95% 0.09463 mg/L 0.05423 mg/L 1.74497510602987 -DTXSID0024923 Css 3compartmentss Human 95% 5.477 mg/L 3.275 mg/L 1.67236641221374 -DTXSID0024977 Css 3compartmentss Human 95% 273.2 mg/L 159.9 mg/L 1.70856785490932 -DTXSID0024979 Css 3compartmentss Human 95% 69.27 mg/L 38.45 mg/L 1.80156046814044 -DTXSID0025070 Css 3compartmentss Human 95% 14.73 mg/L 9.681 mg/L 1.52153703129842 -DTXSID0025074 Css 3compartmentss Human 95% 11.19 mg/L 6.321 mg/L 1.7702895111533 -DTXSID0025076 Css 3compartmentss Human 95% 57.89 mg/L 32.2 mg/L 1.79782608695652 -DTXSID0025078 Css 3compartmentss Human 95% 32.13 mg/L 17.29 mg/L 1.8582995951417 -DTXSID0025101 Css 3compartmentss Human 95% 12.41 mg/L 7.818 mg/L 1.58736249680225 -DTXSID0025234 Css 3compartmentss Human 95% 55.42 mg/L 34.75 mg/L 1.59482014388489 -DTXSID0025361 Css 3compartmentss Human 95% 5.937 mg/L 3.943 mg/L 1.50570631498859 -DTXSID0025363 Css 3compartmentss Human 95% 7.917 mg/L 4.918 mg/L 1.60980073200488 -DTXSID0025367 Css 3compartmentss Human 95% 4.088 mg/L 2.489 mg/L 1.64242667738047 -DTXSID0025440 Css 3compartmentss Human 95% 0.1496 mg/L 0.1218 mg/L 1.22824302134647 -DTXSID0025494 Css 3compartmentss Human 95% 1157 mg/L 2667 mg/L 0.43382077240345 -DTXSID0025523 Css 3compartmentss Human 95% 1.741 mg/L 0.9245 mg/L 1.88318009734992 -DTXSID0025527 Css 3compartmentss Human 95% 1.447 mg/L 0.817 mg/L 1.77111383108935 -DTXSID0025571 Css 3compartmentss Human 95% 0.972 mg/L 0.6583 mg/L 1.47653045723834 -DTXSID0025577 Css 3compartmentss Human 95% 5.122 mg/L 3.441 mg/L 1.48852077884336 -DTXSID0025600 Css 3compartmentss Human 95% 12.73 mg/L 10.98 mg/L 1.15938069216758 -DTXSID0025654 Css 3compartmentss Human 95% 15.77 mg/L 0.08425 mg/L 187.181008902077 -DTXSID0025733 Css 3compartmentss Human 95% 3.683 mg/L 2.309 mg/L 1.59506279774794 -DTXSID0025737 Css 3compartmentss Human 95% 15.41 mg/L 8.963 mg/L 1.71929041615531 -DTXSID0025789 Css 3compartmentss Human 95% 2.299 mg/L 1.673 mg/L 1.3741781231321 -DTXSID0025812 Css 3compartmentss Human 95% 1.283 mg/L 0.7836 mg/L 1.63731495661052 -DTXSID0025814 Css 3compartmentss Human 95% 7.443 mg/L 4.683 mg/L 1.58936579115951 -DTXSID0025816 Css 3compartmentss Human 95% 7.701 mg/L 4.79 mg/L 1.60772442588726 -DTXSID0025818 Css 3compartmentss Human 95% 0.6177 mg/L 0.1465 mg/L 4.21638225255973 -DTXSID0025862 Css 3compartmentss Human 95% 0.6826 mg/L 0.4287 mg/L 1.59225565663634 -DTXSID0025864 Css 3compartmentss Human 95% 0.3423 mg/L 0.239 mg/L 1.43221757322176 -DTXSID0025866 Css 3compartmentss Human 95% 0.7899 mg/L 0.4473 mg/L 1.76592890677398 -DTXSID0025991 Css 3compartmentss Human 95% 0.5578 mg/L 0.3664 mg/L 1.52237991266376 -DTXSID0025997 Css 3compartmentss Human 95% 14.5 mg/L 0.000147 mg/L 98639.4557823129 -DTXSID0026040 Css 3compartmentss Human 95% 0.2758 mg/L 0.2153 mg/L 1.28100325127729 -DTXSID0026044 Css 3compartmentss Human 95% 0.001742 mg/L 0 mg/L Inf -DTXSID0026125 Css 3compartmentss Human 95% 6.354 mg/L 5.749 mg/L 1.10523569316403 -DTXSID0026171 Css 3compartmentss Human 95% 3.289 mg/L 2.264 mg/L 1.45273851590106 -DTXSID0026173 Css 3compartmentss Human 95% 3.219 mg/L 2.217 mg/L 1.45196211096076 -DTXSID0026175 Css 3compartmentss Human 95% 0.6566 mg/L 0.4097 mg/L 1.60263607517696 -DTXSID0026202 Css 3compartmentss Human 95% 136.1 mg/L 214.1 mg/L 0.635684259691733 -DTXSID0026204 Css 3compartmentss Human 95% 26.73 mg/L 17.07 mg/L 1.56590509666081 -DTXSID0026208 Css 3compartmentss Human 95% 64.14 mg/L 22.55 mg/L 2.84434589800443 -DTXSID0026252 Css 3compartmentss Human 95% 4.887 mg/L 0.9253 mg/L 5.2815303144926 -DTXSID0026258 Css 3compartmentss Human 95% 0.04111 mg/L 0.02383 mg/L 1.72513638271087 -DTXSID0026339 Css 3compartmentss Human 95% 35.76 mg/L 9739 mg/L 0.00367183489064586 -DTXSID0026547 Css 3compartmentss Human 95% 11.47 mg/L 6.985 mg/L 1.6420901932713 -DTXSID0026549 Css 3compartmentss Human 95% 5.575 mg/L 3.628 mg/L 1.53665931642778 -DTXSID0026676 Css 3compartmentss Human 95% 132.8 mg/L 157.9 mg/L 0.841038632045598 -DTXSID0026701 Css 3compartmentss Human 95% 7.666 mg/L 4.611 mg/L 1.66254608544784 -DTXSID0026830 Css 3compartmentss Human 95% 8.27 mg/L 5.433 mg/L 1.52217927480213 -DTXSID0026838 Css 3compartmentss Human 95% 11.84 mg/L 2.028e-05 mg/L 583826.429980276 -DTXSID0026880 Css 3compartmentss Human 95% 5.799 mg/L 3.505 mg/L 1.65449358059914 -DTXSID0026915 Css 3compartmentss Human 95% 8.729 mg/L 1.592 mg/L 5.48304020100502 -DTXSID0026961 Css 3compartmentss Human 95% 19.12 mg/L 13.33 mg/L 1.43435858964741 -DTXSID0026967 Css 3compartmentss Human 95% 0.2112 mg/L 0.1127 mg/L 1.87400177462289 -DTXSID0027066 Css 3compartmentss Human 95% 110.8 mg/L 64.23 mg/L 1.72505059940838 -DTXSID0027149 Css 3compartmentss Human 95% 7.735 mg/L 4.837 mg/L 1.59913169319826 -DTXSID0027197 Css 3compartmentss Human 95% 5.506 mg/L 3.354 mg/L 1.64162194394753 -DTXSID0027270 Css 3compartmentss Human 95% 10080 mg/L 9739 mg/L 1.03501386179279 -DTXSID0027301 Css 3compartmentss Human 95% 1.503 mg/L 1.059 mg/L 1.41926345609065 -DTXSID0027309 Css 3compartmentss Human 95% 0.09997 mg/L 0.06461 mg/L 1.54728370221328 -DTXSID00274148 Css 3compartmentss Human 95% 2.867 mg/L 1.602 mg/L 1.7896379525593 -DTXSID0027432 Css 3compartmentss Human 95% 5.732 mg/L 3.948 mg/L 1.45187436676798 -DTXSID0027436 Css 3compartmentss Human 95% 7.317 mg/L 4.6 mg/L 1.59065217391304 -DTXSID0027438 Css 3compartmentss Human 95% 0.8902 mg/L 0.4895 mg/L 1.81859039836568 -DTXSID0027486 Css 3compartmentss Human 95% 7.381 mg/L 4.277 mg/L 1.72574234276362 -DTXSID0027513 Css 3compartmentss Human 95% 8.384 mg/L 5.292 mg/L 1.58427815570673 -DTXSID0027561 Css 3compartmentss Human 95% 0.03248 mg/L 0.02022 mg/L 1.60633036597428 -DTXSID0027565 Css 3compartmentss Human 95% 1.24 mg/L 0.8607 mg/L 1.44068781224585 -DTXSID0027567 Css 3compartmentss Human 95% 10.46 mg/L 10.05 mg/L 1.0407960199005 -DTXSID0027640 Css 3compartmentss Human 95% 7.122 mg/L 4.495 mg/L 1.58442714126808 -DTXSID0027721 Css 3compartmentss Human 95% 60.99 mg/L 9739 mg/L 0.00626244994352603 -DTXSID0027729 Css 3compartmentss Human 95% 5.528 mg/L 3.762 mg/L 1.46943115364168 -DTXSID0027771 Css 3compartmentss Human 95% 54.52 mg/L 0.1629 mg/L 334.683855125844 -DTXSID0027773 Css 3compartmentss Human 95% 38.04 mg/L 69.01 mg/L 0.551224460223156 -DTXSID0027802 Css 3compartmentss Human 95% 1.666 mg/L 0.7421 mg/L 2.24498046085433 -DTXSID0027804 Css 3compartmentss Human 95% 5.37 mg/L 3.613 mg/L 1.48629947412123 -DTXSID0027806 Css 3compartmentss Human 95% 8.439 mg/L 5.277 mg/L 1.59920409323479 -DTXSID0027852 Css 3compartmentss Human 95% 3.194 mg/L 2.636 mg/L 1.21168437025797 -DTXSID0027856 Css 3compartmentss Human 95% 3.116 mg/L 3.42 mg/L 0.911111111111111 -DTXSID0027858 Css 3compartmentss Human 95% 41.92 mg/L 3.242 mg/L 12.9302899444787 -DTXSID0027933 Css 3compartmentss Human 95% 0.3215 mg/L 1e-09 mg/L 321500000 -DTXSID0027981 Css 3compartmentss Human 95% 28.89 mg/L 16.28 mg/L 1.77457002457002 -DTXSID0027983 Css 3compartmentss Human 95% 5.068 mg/L 3.562 mg/L 1.42279618192027 -DTXSID0028030 Css 3compartmentss Human 95% 0.004478 mg/L 5.555e-06 mg/L 806.120612061206 -DTXSID0028038 Css 3compartmentss Human 95% 0.01517 mg/L 0.01066 mg/L 1.42307692307692 -DTXSID0028323 Css 3compartmentss Human 95% 2026 mg/L 9739 mg/L 0.208029571824623 -DTXSID0028618 Css 3compartmentss Human 95% 0.5223 mg/L 0.3586 mg/L 1.45649749023982 -DTXSID0028666 Css 3compartmentss Human 95% 0.003494 mg/L 0 mg/L Inf -DTXSID0029133 Css 3compartmentss Human 95% 0.6303 mg/L 0.4168 mg/L 1.51223608445297 -DTXSID0029189 Css 3compartmentss Human 95% 5.97 mg/L 3.822 mg/L 1.56200941915228 -DTXSID0029210 Css 3compartmentss Human 95% 0.816 mg/L 0.01224 mg/L 66.6666666666667 -DTXSID0029214 Css 3compartmentss Human 95% 13.37 mg/L 4.605 mg/L 2.90336590662324 -DTXSID0029260 Css 3compartmentss Human 95% 5.889 mg/L 3.4 mg/L 1.73205882352941 -DTXSID0029262 Css 3compartmentss Human 95% 16.55 mg/L 0.3619 mg/L 45.7308648798011 -DTXSID0029474 Css 3compartmentss Human 95% 89.36 mg/L 63.88 mg/L 1.39887288666249 -DTXSID0029559 Css 3compartmentss Human 95% 0.07002 mg/L 0.01576 mg/L 4.44289340101523 -DTXSID0029688 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID0029761 Css 3compartmentss Human 95% 8.329 mg/L 5.107 mg/L 1.63089876639906 -DTXSID0029848 Css 3compartmentss Human 95% 13.01 mg/L 5.923 mg/L 2.19652203275367 -DTXSID0030162 Css 3compartmentss Human 95% 0.9666 mg/L 0.6602 mg/L 1.46410178733717 -DTXSID0030588 Css 3compartmentss Human 95% 0.2277 mg/L 0.1907 mg/L 1.19402202412166 -DTXSID0032029 Css 3compartmentss Human 95% 0.2997 mg/L 0.1838 mg/L 1.63057671381937 -DTXSID0032077 Css 3compartmentss Human 95% 7.614 mg/L 4.76 mg/L 1.59957983193277 -DTXSID0032314 Css 3compartmentss Human 95% 4.2 mg/L 2.731 mg/L 1.53789820578543 -DTXSID0032316 Css 3compartmentss Human 95% 3.382 mg/L 2.406 mg/L 1.40565253532835 -DTXSID0032493 Css 3compartmentss Human 95% 44.36 mg/L 44.02 mg/L 1.0077237619264 -DTXSID0032497 Css 3compartmentss Human 95% 306.7 mg/L 176.7 mg/L 1.73571024335031 -DTXSID0032520 Css 3compartmentss Human 95% 3.716 mg/L 1.779 mg/L 2.08881394041596 -DTXSID0032572 Css 3compartmentss Human 95% 4.341 mg/L 0.533 mg/L 8.14446529080675 -DTXSID0032578 Css 3compartmentss Human 95% 0.01884 mg/L 0.01152 mg/L 1.63541666666667 -DTXSID0032601 Css 3compartmentss Human 95% 15.59 mg/L 11.44 mg/L 1.36276223776224 -DTXSID0032605 Css 3compartmentss Human 95% 1156 mg/L 2109 mg/L 0.548127074442864 -DTXSID0032651 Css 3compartmentss Human 95% 226.8 mg/L 139.1 mg/L 1.63048166786485 -DTXSID0032655 Css 3compartmentss Human 95% 7.001 mg/L 5.044 mg/L 1.38798572561459 -DTXSID0032811 Css 3compartmentss Human 95% 8.245 mg/L 5.336 mg/L 1.54516491754123 -DTXSID0032813 Css 3compartmentss Human 95% 8.716 mg/L 5.716 mg/L 1.52484254723583 -DTXSID0032998 Css 3compartmentss Human 95% 7.997 mg/L 5.019 mg/L 1.59334528790596 -DTXSID0033047 Css 3compartmentss Human 95% 1.343 mg/L 1.055 mg/L 1.27298578199052 -DTXSID0033332 Css 3compartmentss Human 95% 55.08 mg/L 31.8 mg/L 1.73207547169811 -DTXSID0033334 Css 3compartmentss Human 95% 0.4446 mg/L 0.1757 mg/L 2.53044963005122 -DTXSID0033382 Css 3compartmentss Human 95% 4.339 mg/L 2.563 mg/L 1.69293796332423 -DTXSID0033469 Css 3compartmentss Human 95% 8.744 mg/L 5.417 mg/L 1.61417758907144 -DTXSID0033673 Css 3compartmentss Human 95% 6.093 mg/L 4.363 mg/L 1.39651615860646 -DTXSID0033754 Css 3compartmentss Human 95% 3.24 mg/L 3.263 mg/L 0.992951271835734 -DTXSID0033960 Css 3compartmentss Human 95% 103.5 mg/L 285.5 mg/L 0.362521891418564 -DTXSID0034192 Css 3compartmentss Human 95% 1.061 mg/L 0.5494 mg/L 1.93119767018566 -DTXSID0034223 Css 3compartmentss Human 95% 17.12 mg/L 1.634 mg/L 10.4773561811506 -DTXSID0034227 Css 3compartmentss Human 95% 0.6025 mg/L 0.3912 mg/L 1.54013292433538 -DTXSID0034229 Css 3compartmentss Human 95% 12.08 mg/L 12.23 mg/L 0.987735077677841 -DTXSID0034300 Css 3compartmentss Human 95% 9.199 mg/L 5.329 mg/L 1.7262150497279 -DTXSID0034518 Css 3compartmentss Human 95% 3.683 mg/L 1.496 mg/L 2.46189839572193 -DTXSID0034566 Css 3compartmentss Human 95% 4415 mg/L 2264 mg/L 1.95008833922261 -DTXSID0034695 Css 3compartmentss Human 95% 2.332 mg/L 1.338 mg/L 1.74289985052317 -DTXSID0034722 Css 3compartmentss Human 95% 82.05 mg/L 45.92 mg/L 1.7868031358885 -DTXSID0034776 Css 3compartmentss Human 95% 1.629 mg/L 0.1456 mg/L 11.1881868131868 -DTXSID0034803 Css 3compartmentss Human 95% 673.1 mg/L 387.5 mg/L 1.73703225806452 -DTXSID0034851 Css 3compartmentss Human 95% 293.4 mg/L 169.5 mg/L 1.73097345132743 -DTXSID0034855 Css 3compartmentss Human 95% 1.82 mg/L 0.1615 mg/L 11.2693498452012 -DTXSID0034930 Css 3compartmentss Human 95% 7.646 mg/L 5.523 mg/L 1.38439254028608 -DTXSID0034936 Css 3compartmentss Human 95% 14 mg/L 7.628 mg/L 1.83534347142108 -DTXSID0035748 Css 3compartmentss Human 95% 5.194 mg/L 3.25 mg/L 1.59815384615385 -DTXSID0035790 Css 3compartmentss Human 95% 0.5889 mg/L 0.3764 mg/L 1.56455897980871 -DTXSID0036508 Css 3compartmentss Human 95% 5.17 mg/L 3.425 mg/L 1.50948905109489 -DTXSID0036760 Css 3compartmentss Human 95% 1.402 mg/L 0.7656 mg/L 1.8312434691745 -DTXSID0037023 Css 3compartmentss Human 95% 4.393 mg/L 2.763 mg/L 1.58993847267463 -DTXSID0037231 Css 3compartmentss Human 95% 33.34 mg/L 16.93 mg/L 1.96928529238039 -DTXSID0037235 Css 3compartmentss Human 95% 0.424 mg/L 0.277 mg/L 1.53068592057762 -DTXSID0037237 Css 3compartmentss Human 95% 35.31 mg/L 18.93 mg/L 1.86529318541997 -DTXSID0037493 Css 3compartmentss Human 95% 0.7761 mg/L 0.6643 mg/L 1.16829745596869 -DTXSID0037495 Css 3compartmentss Human 95% 7.646 mg/L 5.018 mg/L 1.52371462734157 -DTXSID0037522 Css 3compartmentss Human 95% 2.888 mg/L 0.2132 mg/L 13.5459662288931 -DTXSID0037570 Css 3compartmentss Human 95% 0.9177 mg/L 0.5953 mg/L 1.54157567612968 -DTXSID0037576 Css 3compartmentss Human 95% 12.6 mg/L 8.362 mg/L 1.50681655106434 -DTXSID0037730 Css 3compartmentss Human 95% 21.62 mg/L 11.53 mg/L 1.87510841283608 -DTXSID0037734 Css 3compartmentss Human 95% 112 mg/L 10.84 mg/L 10.3321033210332 -DTXSID0038700 Css 3compartmentss Human 95% 0.3288 mg/L 0.1993 mg/L 1.64977420973407 -DTXSID0038756 Css 3compartmentss Human 95% 1.277 mg/L 0.9557 mg/L 1.33619336611908 -DTXSID0038831 Css 3compartmentss Human 95% 7.255 mg/L 4.411 mg/L 1.64475175697121 -DTXSID0038839 Css 3compartmentss Human 95% 1.284 mg/L 0.8064 mg/L 1.5922619047619 -DTXSID0038881 Css 3compartmentss Human 95% 9.519 mg/L 5.016 mg/L 1.89772727272727 -DTXSID0038887 Css 3compartmentss Human 95% 20.22 mg/L 13 mg/L 1.55538461538462 -DTXSID0039223 Css 3compartmentss Human 95% 7.562 mg/L 4.755 mg/L 1.59032597266036 -DTXSID0039227 Css 3compartmentss Human 95% 11.12 mg/L 7.612 mg/L 1.46085128744088 -DTXSID0039229 Css 3compartmentss Human 95% 8.257 mg/L 5.2 mg/L 1.58788461538462 -DTXSID0040127 Css 3compartmentss Human 95% 3.318 mg/L 2.233 mg/L 1.4858934169279 -DTXSID0040129 Css 3compartmentss Human 95% 0.08942 mg/L 0.05153 mg/L 1.73529982534446 -DTXSID0040208 Css 3compartmentss Human 95% 6.84 mg/L 3.677 mg/L 1.86021212945336 -DTXSID0040464 Css 3compartmentss Human 95% 0.3481 mg/L 0.1538 mg/L 2.26332899869961 -DTXSID0040547 Css 3compartmentss Human 95% 10.13 mg/L 5.763 mg/L 1.75776505292382 -DTXSID0040599 Css 3compartmentss Human 95% 0.3902 mg/L 0.1507 mg/L 2.5892501658925 -DTXSID0040620 Css 3compartmentss Human 95% 5.666 mg/L 3.628 mg/L 1.56174200661522 -DTXSID0040622 Css 3compartmentss Human 95% 1.112 mg/L 0.7937 mg/L 1.40103313594557 -DTXSID0040672 Css 3compartmentss Human 95% 13.75 mg/L 6.904 mg/L 1.99159907300116 -DTXSID0040674 Css 3compartmentss Human 95% 3.612 mg/L 1.989 mg/L 1.81598793363499 -DTXSID0040676 Css 3compartmentss Human 95% 113.6 mg/L 61.3 mg/L 1.8531810766721 -DTXSID0040678 Css 3compartmentss Human 95% 75.32 mg/L 113.2 mg/L 0.665371024734982 -DTXSID0040701 Css 3compartmentss Human 95% 0.1207 mg/L 0.07643 mg/L 1.57922281826508 -DTXSID0040703 Css 3compartmentss Human 95% 100.6 mg/L 54.18 mg/L 1.85677371723883 -DTXSID0040705 Css 3compartmentss Human 95% 187.4 mg/L 97.55 mg/L 1.92106611993849 -DTXSID0040707 Css 3compartmentss Human 95% 7.879 mg/L 3.277 mg/L 2.40433323161428 -DTXSID0040751 Css 3compartmentss Human 95% 119 mg/L 56.03 mg/L 2.12386221666964 -DTXSID0040755 Css 3compartmentss Human 95% 0.7618 mg/L 0.1178 mg/L 6.46689303904924 -DTXSID0040757 Css 3compartmentss Human 95% 122.4 mg/L 55.32 mg/L 2.21258134490239 -DTXSID0040965 Css 3compartmentss Human 95% 53.3 mg/L 1.82 mg/L 29.2857142857143 -DTXSID0041060 Css 3compartmentss Human 95% 1.238 mg/L 0.8426 mg/L 1.4692618086874 -DTXSID0041141 Css 3compartmentss Human 95% 1.363 mg/L 0.7042 mg/L 1.93552967906845 -DTXSID0041197 Css 3compartmentss Human 95% 620 mg/L 1310 mg/L 0.473282442748092 -DTXSID0041220 Css 3compartmentss Human 95% 3.24 mg/L 1.409 mg/L 2.29950319375444 -DTXSID0041224 Css 3compartmentss Human 95% 5.484 mg/L 3.223 mg/L 1.70152032268073 -DTXSID0041274 Css 3compartmentss Human 95% 2.287 mg/L 1.416 mg/L 1.61511299435028 -DTXSID0041359 Css 3compartmentss Human 95% 12.97 mg/L 5.113 mg/L 2.53667123019754 -DTXSID0041436 Css 3compartmentss Human 95% 5.689 mg/L 3.822 mg/L 1.48848770277342 -DTXSID0041513 Css 3compartmentss Human 95% 1.204 mg/L 0.8388 mg/L 1.43538388173581 -DTXSID0041517 Css 3compartmentss Human 95% 5.54 mg/L 3.448 mg/L 1.60672853828306 -DTXSID0041567 Css 3compartmentss Human 95% 568 mg/L 739.6 mg/L 0.767982693347755 -DTXSID0041646 Css 3compartmentss Human 95% 89.49 mg/L 48.73 mg/L 1.83644572132157 -DTXSID0041692 Css 3compartmentss Human 95% 0.4418 mg/L 0.2905 mg/L 1.52082616179002 -DTXSID0041698 Css 3compartmentss Human 95% 0.3037 mg/L 0.1809 mg/L 1.67882808181316 -DTXSID0041721 Css 3compartmentss Human 95% 7.814 mg/L 3.397 mg/L 2.30026493965263 -DTXSID0041850 Css 3compartmentss Human 95% 1.873 mg/L 0.7554 mg/L 2.47948106963198 -DTXSID0041852 Css 3compartmentss Human 95% 36.34 mg/L 20.63 mg/L 1.76151236063985 -DTXSID0041981 Css 3compartmentss Human 95% 8.864 mg/L 5.528 mg/L 1.60347322720695 -DTXSID0041983 Css 3compartmentss Human 95% 5.1 mg/L 2.187 mg/L 2.33196159122085 -DTXSID0041985 Css 3compartmentss Human 95% 22.86 mg/L 7.279 mg/L 3.14054128314329 -DTXSID0041987 Css 3compartmentss Human 95% 16.78 mg/L 6.267 mg/L 2.67751715334291 -DTXSID0042080 Css 3compartmentss Human 95% 2.298 mg/L 0.6227 mg/L 3.69038060061025 -DTXSID0042084 Css 3compartmentss Human 95% 0.4146 mg/L 0.1461 mg/L 2.83778234086242 -DTXSID0042086 Css 3compartmentss Human 95% 44.11 mg/L 0.4981 mg/L 88.5565147560731 -DTXSID0042117 Css 3compartmentss Human 95% 0.2464 mg/L 0.1313 mg/L 1.87661843107388 -DTXSID0042167 Css 3compartmentss Human 95% 11.87 mg/L 7.16 mg/L 1.65782122905028 -DTXSID0042169 Css 3compartmentss Human 95% 4.142 mg/L 2.4 mg/L 1.72583333333333 -DTXSID0042242 Css 3compartmentss Human 95% 2.293 mg/L 1.562 mg/L 1.46798975672215 -DTXSID0042244 Css 3compartmentss Human 95% 10.12 mg/L 3.992 mg/L 2.53507014028056 -DTXSID0042248 Css 3compartmentss Human 95% 1.527 mg/L 0.6348 mg/L 2.4054820415879 -DTXSID0042325 Css 3compartmentss Human 95% 0.9598 mg/L 0.6374 mg/L 1.50580483213053 -DTXSID0042327 Css 3compartmentss Human 95% 2.529 mg/L 1.608 mg/L 1.57276119402985 -DTXSID0042400 Css 3compartmentss Human 95% 187.2 mg/L 71.19 mg/L 2.62958280657396 -DTXSID0042406 Css 3compartmentss Human 95% 9.595 mg/L 5.839 mg/L 1.6432608323343 -DTXSID0042454 Css 3compartmentss Human 95% 1745 mg/L 3384 mg/L 0.515661938534279 -DTXSID0042583 Css 3compartmentss Human 95% 1.986 mg/L 1.395 mg/L 1.42365591397849 -DTXSID0042612 Css 3compartmentss Human 95% 2.332 mg/L 0.8148 mg/L 2.86205203730977 -DTXSID0042614 Css 3compartmentss Human 95% 1.696 mg/L 0.6845 mg/L 2.47772096420745 -DTXSID0042618 Css 3compartmentss Human 95% 0.3652 mg/L 0.1935 mg/L 1.88733850129199 -DTXSID0042668 Css 3compartmentss Human 95% 6.531 mg/L 4.014 mg/L 1.6270553064275 -DTXSID0043761 Css 3compartmentss Human 95% 141.3 mg/L 174.5 mg/L 0.80974212034384 -DTXSID0043763 Css 3compartmentss Human 95% 0.6055 mg/L 0.6361 mg/L 0.951894356233297 -DTXSID0043765 Css 3compartmentss Human 95% 0.06118 mg/L 0.03553 mg/L 1.72192513368984 -DTXSID0043848 Css 3compartmentss Human 95% 0.0546 mg/L 0.03641 mg/L 1.49958802526778 -DTXSID0043892 Css 3compartmentss Human 95% 11.02 mg/L 4.391 mg/L 2.50967888863585 -DTXSID0043896 Css 3compartmentss Human 95% 35.79 mg/L 24.78 mg/L 1.44430992736077 -DTXSID0044024 Css 3compartmentss Human 95% 39.74 mg/L 18.74 mg/L 2.12059765208111 -DTXSID0044107 Css 3compartmentss Human 95% 45.41 mg/L 24.95 mg/L 1.82004008016032 -DTXSID0044236 Css 3compartmentss Human 95% 11230 mg/L 9730 mg/L 1.15416238437821 -DTXSID0044280 Css 3compartmentss Human 95% 1.186 mg/L 0.6045 mg/L 1.96195202646816 -DTXSID0044288 Css 3compartmentss Human 95% 16.02 mg/L 9.839 mg/L 1.62821424941559 -DTXSID0044313 Css 3compartmentss Human 95% 7.418 mg/L 5.367 mg/L 1.38215017700764 -DTXSID0044315 Css 3compartmentss Human 95% 30.23 mg/L 18.28 mg/L 1.65371991247265 -DTXSID0044317 Css 3compartmentss Human 95% 11.62 mg/L 7.102 mg/L 1.63615882849901 -DTXSID0044361 Css 3compartmentss Human 95% 1.172 mg/L 0.875 mg/L 1.33942857142857 -DTXSID0044365 Css 3compartmentss Human 95% 4.868 mg/L 3.362 mg/L 1.44794765020821 -DTXSID0044369 Css 3compartmentss Human 95% 0.3983 mg/L 0.2013 mg/L 1.97863884749131 -DTXSID0044440 Css 3compartmentss Human 95% 4.956 mg/L 0.8454 mg/L 5.86231369765791 -DTXSID0044446 Css 3compartmentss Human 95% 3.377 mg/L 2.368 mg/L 1.42609797297297 -DTXSID0044448 Css 3compartmentss Human 95% 7.56 mg/L 4.633 mg/L 1.63177206993309 -DTXSID0044490 Css 3compartmentss Human 95% 2.638 mg/L 1.625 mg/L 1.62338461538462 -DTXSID0044494 Css 3compartmentss Human 95% 2.723 mg/L 1.212 mg/L 2.246699669967 -DTXSID0044496 Css 3compartmentss Human 95% 23.82 mg/L 33.53 mg/L 0.710408589322994 -DTXSID0044521 Css 3compartmentss Human 95% 0.9031 mg/L 0.4803 mg/L 1.88028315636061 -DTXSID0044523 Css 3compartmentss Human 95% 7.714 mg/L 4.743 mg/L 1.62639679527725 -DTXSID0044525 Css 3compartmentss Human 95% 5.744 mg/L 3.652 mg/L 1.57283680175246 -DTXSID0044527 Css 3compartmentss Human 95% 6.536 mg/L 4.071 mg/L 1.60550233357897 -DTXSID0044571 Css 3compartmentss Human 95% 1.71 mg/L 0.9048 mg/L 1.88992042440318 -DTXSID0044575 Css 3compartmentss Human 95% 6.602 mg/L 6.393 mg/L 1.03269200688253 -DTXSID0044577 Css 3compartmentss Human 95% 28.35 mg/L 49.4 mg/L 0.573886639676113 -DTXSID0044600 Css 3compartmentss Human 95% 6.835 mg/L 4.825 mg/L 1.41658031088083 -DTXSID0044606 Css 3compartmentss Human 95% 0.3199 mg/L 0.1871 mg/L 1.70978086584714 -DTXSID0044650 Css 3compartmentss Human 95% 0.2485 mg/L 0.1588 mg/L 1.56486146095718 -DTXSID0044654 Css 3compartmentss Human 95% 0.7882 mg/L 0.5041 mg/L 1.56357865502876 -DTXSID0044656 Css 3compartmentss Human 95% 0.2076 mg/L 0.1281 mg/L 1.62060889929742 -DTXSID0044658 Css 3compartmentss Human 95% 2.278 mg/L 1.522 mg/L 1.49671484888305 -DTXSID0044731 Css 3compartmentss Human 95% 68.55 mg/L 41.69 mg/L 1.64427920364596 -DTXSID0044733 Css 3compartmentss Human 95% 15.41 mg/L 8.963 mg/L 1.71929041615531 -DTXSID0044735 Css 3compartmentss Human 95% 9.05 mg/L 5.594 mg/L 1.61780479084734 -DTXSID0044737 Css 3compartmentss Human 95% 1.57 mg/L 0.9311 mg/L 1.6861776393513 -DTXSID0044783 Css 3compartmentss Human 95% 0.175 mg/L 0.1248 mg/L 1.40224358974359 -DTXSID0044785 Css 3compartmentss Human 95% 6.147 mg/L 3.744 mg/L 1.64182692307692 -DTXSID0044787 Css 3compartmentss Human 95% 279.9 mg/L 163.5 mg/L 1.71192660550459 -DTXSID0044810 Css 3compartmentss Human 95% 2.944 mg/L 1.966 mg/L 1.49745676500509 -DTXSID0044812 Css 3compartmentss Human 95% 5.162 mg/L 2.315 mg/L 2.22980561555076 -DTXSID0044816 Css 3compartmentss Human 95% 1.477 mg/L 1.006 mg/L 1.46819085487078 -DTXSID0044818 Css 3compartmentss Human 95% 236.9 mg/L 9.101 mg/L 26.0301065816943 -DTXSID0044860 Css 3compartmentss Human 95% 1.833 mg/L 0.8202 mg/L 2.23482077542063 -DTXSID0044862 Css 3compartmentss Human 95% 13.15 mg/L 8.866 mg/L 1.48319422512971 -DTXSID0044868 Css 3compartmentss Human 95% 3.681 mg/L 2.353 mg/L 1.56438589035274 -DTXSID0044941 Css 3compartmentss Human 95% 6.133 mg/L 3.561 mg/L 1.72226902555462 -DTXSID0044943 Css 3compartmentss Human 95% 2.876 mg/L 1.773 mg/L 1.62210941906373 -DTXSID0044945 Css 3compartmentss Human 95% 0.0632 mg/L 0.03791 mg/L 1.66710630440517 -DTXSID0044947 Css 3compartmentss Human 95% 5.746 mg/L 3.324 mg/L 1.72864019253911 -DTXSID0044949 Css 3compartmentss Human 95% 5.645 mg/L 3.699 mg/L 1.52608813192755 -DTXSID0044993 Css 3compartmentss Human 95% 3.382 mg/L 2.28 mg/L 1.48333333333333 -DTXSID0044995 Css 3compartmentss Human 95% 21.18 mg/L 10.08 mg/L 2.10119047619048 -DTXSID0044997 Css 3compartmentss Human 95% 1.712 mg/L 0.5985 mg/L 2.86048454469507 -DTXSID0044999 Css 3compartmentss Human 95% 5.658 mg/L 3.477 mg/L 1.62726488352028 -DTXSID0045090 Css 3compartmentss Human 95% 1.29 mg/L 0.4485 mg/L 2.87625418060201 -DTXSID0045094 Css 3compartmentss Human 95% 45.32 mg/L 26.69 mg/L 1.69801423754215 -DTXSID0045096 Css 3compartmentss Human 95% 2.384 mg/L 0.5688 mg/L 4.19127988748242 -DTXSID0045125 Css 3compartmentss Human 95% 231.1 mg/L 481.6 mg/L 0.479858803986711 -DTXSID0045127 Css 3compartmentss Human 95% 0.1207 mg/L 0.05978 mg/L 2.01906992305119 -DTXSID0045171 Css 3compartmentss Human 95% 0.9043 mg/L 0.5695 mg/L 1.58788410886743 -DTXSID0045173 Css 3compartmentss Human 95% 7.48 mg/L 4.823 mg/L 1.55090192826042 -DTXSID0045175 Css 3compartmentss Human 95% 0.06667 mg/L 0.02501 mg/L 2.66573370651739 -DTXSID0045179 Css 3compartmentss Human 95% 2.386 mg/L 1.459 mg/L 1.63536668951337 -DTXSID0045202 Css 3compartmentss Human 95% 0.5134 mg/L 0.3162 mg/L 1.62365591397849 -DTXSID0045204 Css 3compartmentss Human 95% 0.01684 mg/L 0.01807 mg/L 0.931931377974544 -DTXSID0045206 Css 3compartmentss Human 95% 2.77 mg/L 1.605 mg/L 1.72585669781931 -DTXSID0045208 Css 3compartmentss Human 95% 5.722 mg/L 2.042 mg/L 2.80215475024486 -DTXSID0045250 Css 3compartmentss Human 95% 2.543 mg/L 1.59 mg/L 1.59937106918239 -DTXSID0045252 Css 3compartmentss Human 95% 10.06 mg/L 6.096 mg/L 1.6502624671916 -DTXSID0045254 Css 3compartmentss Human 95% 3.071 mg/L 1.812 mg/L 1.69481236203091 -DTXSID0045383 Css 3compartmentss Human 95% 0.1381 mg/L 0.08255 mg/L 1.67292549969715 -DTXSID0045385 Css 3compartmentss Human 95% 5.139 mg/L 3.381 mg/L 1.51996450754215 -DTXSID0045389 Css 3compartmentss Human 95% 156.3 mg/L 83.73 mg/L 1.86671443926908 -DTXSID0045412 Css 3compartmentss Human 95% 5.667 mg/L 3.159 mg/L 1.79392212725546 -DTXSID0045414 Css 3compartmentss Human 95% 239.2 mg/L 599.5 mg/L 0.398999165971643 -DTXSID0045416 Css 3compartmentss Human 95% 0.9346 mg/L 0.7274 mg/L 1.28485015122354 -DTXSID0045460 Css 3compartmentss Human 95% 26.22 mg/L 7.353 mg/L 3.56589147286822 -DTXSID0045462 Css 3compartmentss Human 95% 94.76 mg/L 54.02 mg/L 1.75416512402814 -DTXSID0045464 Css 3compartmentss Human 95% 0.7149 mg/L 1e-08 mg/L 71490000 -DTXSID0045466 Css 3compartmentss Human 95% 0.3366 mg/L 0.2247 mg/L 1.49799732977303 -DTXSID0045468 Css 3compartmentss Human 95% 0.9811 mg/L 0.5517 mg/L 1.77832155156788 -DTXSID0045543 Css 3compartmentss Human 95% 0.2362 mg/L 0.1888 mg/L 1.2510593220339 -DTXSID0045545 Css 3compartmentss Human 95% 487.8 mg/L 40.85 mg/L 11.9412484700122 -DTXSID0045547 Css 3compartmentss Human 95% 0.8528 mg/L 0.58 mg/L 1.47034482758621 -DTXSID0045591 Css 3compartmentss Human 95% 0.149 mg/L 0.1 mg/L 1.49 -DTXSID0045595 Css 3compartmentss Human 95% 12.26 mg/L 7.535 mg/L 1.62707365627074 -DTXSID0045597 Css 3compartmentss Human 95% 124.8 mg/L 105.5 mg/L 1.18293838862559 -DTXSID0045599 Css 3compartmentss Human 95% 8.059 mg/L 5.103 mg/L 1.57926709778562 -DTXSID0045624 Css 3compartmentss Human 95% 5.623 mg/L 3.632 mg/L 1.54818281938326 -DTXSID0045626 Css 3compartmentss Human 95% 9.761 mg/L 5.676 mg/L 1.71969696969697 -DTXSID0045670 Css 3compartmentss Human 95% 5.538 mg/L 3.307 mg/L 1.67462957363169 -DTXSID0045674 Css 3compartmentss Human 95% 0.9925 mg/L 0.8047 mg/L 1.23337889896856 -DTXSID0045676 Css 3compartmentss Human 95% 8.063 mg/L 4.167 mg/L 1.93496520278378 -DTXSID0045678 Css 3compartmentss Human 95% 0.03789 mg/L 0.02284 mg/L 1.65893169877408 -DTXSID0045701 Css 3compartmentss Human 95% 0.4016 mg/L 0.2415 mg/L 1.66293995859213 -DTXSID0045703 Css 3compartmentss Human 95% 1.74 mg/L 1.024 mg/L 1.69921875 -DTXSID0045705 Css 3compartmentss Human 95% 0.1016 mg/L 0.07333 mg/L 1.3855175235238 -DTXSID0045707 Css 3compartmentss Human 95% 0.9319 mg/L 0.5133 mg/L 1.81550750048704 -DTXSID0045709 Css 3compartmentss Human 95% 1.061 mg/L 0.6616 mg/L 1.60368802902056 -DTXSID0045751 Css 3compartmentss Human 95% 8.695 mg/L 5.464 mg/L 1.59132503660322 -DTXSID0045753 Css 3compartmentss Human 95% 0.8627 mg/L 0.6428 mg/L 1.34209707529558 -DTXSID0045755 Css 3compartmentss Human 95% 6.075 mg/L 3.555 mg/L 1.70886075949367 -DTXSID0045757 Css 3compartmentss Human 95% 19.17 mg/L 0.4937 mg/L 38.8292485314969 -DTXSID0045759 Css 3compartmentss Human 95% 6.004 mg/L 3.694 mg/L 1.62533838657282 -DTXSID0045830 Css 3compartmentss Human 95% 7.016 mg/L 4.283 mg/L 1.63810413261732 -DTXSID0045832 Css 3compartmentss Human 95% 6.352 mg/L 4.35 mg/L 1.46022988505747 -DTXSID0045836 Css 3compartmentss Human 95% 7.16 mg/L 4.848 mg/L 1.47689768976898 -DTXSID0045838 Css 3compartmentss Human 95% 2.096 mg/L 1.453 mg/L 1.44253269098417 -DTXSID0045880 Css 3compartmentss Human 95% 2.267 mg/L 0.8899 mg/L 2.54747724463423 -DTXSID0045886 Css 3compartmentss Human 95% 1.247 mg/L 0.03588 mg/L 34.7547380156076 -DTXSID0045888 Css 3compartmentss Human 95% 5.117 mg/L 3.066 mg/L 1.6689497716895 -DTXSID0045961 Css 3compartmentss Human 95% 0.3226 mg/L 0.2594 mg/L 1.24363916730917 -DTXSID0045963 Css 3compartmentss Human 95% 0.04678 mg/L 0.03427 mg/L 1.36504231105924 -DTXSID0045965 Css 3compartmentss Human 95% 2.515 mg/L 0.3584 mg/L 7.01729910714286 -DTXSID0045967 Css 3compartmentss Human 95% 13.42 mg/L 8.373 mg/L 1.60277081093993 -DTXSID0046010 Css 3compartmentss Human 95% 5.727 mg/L 3.108 mg/L 1.84266409266409 -DTXSID0046012 Css 3compartmentss Human 95% 5.815 mg/L 3.614 mg/L 1.60902047592695 -DTXSID0046016 Css 3compartmentss Human 95% 4.877 mg/L 3.425 mg/L 1.42394160583942 -DTXSID0046060 Css 3compartmentss Human 95% 0.8538 mg/L 0.7249 mg/L 1.17781763001793 -DTXSID0046062 Css 3compartmentss Human 95% 40.61 mg/L 11.28 mg/L 3.60017730496454 -DTXSID0046064 Css 3compartmentss Human 95% 5.573 mg/L 3.628 mg/L 1.53610804851158 -DTXSID0046066 Css 3compartmentss Human 95% 1.141 mg/L 0.6556 mg/L 1.74039048200122 -DTXSID0046143 Css 3compartmentss Human 95% 4.897 mg/L 1.27 mg/L 3.85590551181102 -DTXSID0046145 Css 3compartmentss Human 95% 1.022 mg/L 0.1585 mg/L 6.44794952681388 -DTXSID0046147 Css 3compartmentss Human 95% 0.6834 mg/L 0.4804 mg/L 1.4225645295587 -DTXSID0046191 Css 3compartmentss Human 95% 0.2202 mg/L 0.1773 mg/L 1.2419627749577 -DTXSID0046193 Css 3compartmentss Human 95% 0.3697 mg/L 0.2038 mg/L 1.81403336604514 -DTXSID0046195 Css 3compartmentss Human 95% 0.01377 mg/L 0.008235 mg/L 1.67213114754098 -DTXSID0046197 Css 3compartmentss Human 95% 1.738 mg/L 0.9524 mg/L 1.82486350272995 -DTXSID0046199 Css 3compartmentss Human 95% 3.912 mg/L 2.409 mg/L 1.6239103362391 -DTXSID0046220 Css 3compartmentss Human 95% 5.976 mg/L 3.835 mg/L 1.55827900912647 -DTXSID0046222 Css 3compartmentss Human 95% 2.103 mg/L 0.7145 mg/L 2.94331700489853 -DTXSID0046224 Css 3compartmentss Human 95% 5.126 mg/L 3.344 mg/L 1.53289473684211 -DTXSID0046226 Css 3compartmentss Human 95% 21.42 mg/L 11.67 mg/L 1.83547557840617 -DTXSID0046228 Css 3compartmentss Human 95% 474.7 mg/L 263.4 mg/L 1.80220197418375 -DTXSID0046270 Css 3compartmentss Human 95% 0.3802 mg/L 0.2405 mg/L 1.58087318087318 -DTXSID0046272 Css 3compartmentss Human 95% 3.83 mg/L 2.01 mg/L 1.90547263681592 -DTXSID0046274 Css 3compartmentss Human 95% 0.2337 mg/L 0.1554 mg/L 1.503861003861 -DTXSID0046276 Css 3compartmentss Human 95% 52.23 mg/L 24.32 mg/L 2.14761513157895 -DTXSID0046305 Css 3compartmentss Human 95% 2.544 mg/L 0.02023 mg/L 125.753830944142 -DTXSID0046307 Css 3compartmentss Human 95% 5.612 mg/L 3.261 mg/L 1.72094449555351 -DTXSID0046309 Css 3compartmentss Human 95% 4.06 mg/L 0.4035 mg/L 10.0619578686493 -DTXSID0046351 Css 3compartmentss Human 95% 1.278 mg/L 0.6381 mg/L 2.00282087447109 -DTXSID0046353 Css 3compartmentss Human 95% 1.105 mg/L 0.6513 mg/L 1.69660678642715 -DTXSID0046357 Css 3compartmentss Human 95% 989.3 mg/L 2379 mg/L 0.415846994535519 -DTXSID0046430 Css 3compartmentss Human 95% 3.478 mg/L 2.093 mg/L 1.66172957477305 -DTXSID0046432 Css 3compartmentss Human 95% 1.087 mg/L 0.6881 mg/L 1.57971225112629 -DTXSID0046434 Css 3compartmentss Human 95% 0.06036 mg/L 0.04594 mg/L 1.31388767958206 -DTXSID0046438 Css 3compartmentss Human 95% 59.93 mg/L 35.23 mg/L 1.70110701107011 -DTXSID0046480 Css 3compartmentss Human 95% 6.116 mg/L 3.337 mg/L 1.83278393766856 -DTXSID0046482 Css 3compartmentss Human 95% 11.41 mg/L 6.165 mg/L 1.8507704785077 -DTXSID0046484 Css 3compartmentss Human 95% 0.2881 mg/L 0.1742 mg/L 1.65384615384615 -DTXSID0046486 Css 3compartmentss Human 95% 2.283 mg/L 0.9392 mg/L 2.43079216354344 -DTXSID0046488 Css 3compartmentss Human 95% 9.168 mg/L 2.796 mg/L 3.27896995708155 -DTXSID0046513 Css 3compartmentss Human 95% 0.2164 mg/L 1.02e-07 mg/L 2121568.62745098 -DTXSID0046517 Css 3compartmentss Human 95% 0.6614 mg/L 0.4251 mg/L 1.55586920724535 -DTXSID0046561 Css 3compartmentss Human 95% 0.1439 mg/L 0.09617 mg/L 1.49630862015181 -DTXSID0046563 Css 3compartmentss Human 95% 0.07976 mg/L 0.04279 mg/L 1.8639869128301 -DTXSID0046565 Css 3compartmentss Human 95% 39.48 mg/L 20.78 mg/L 1.89990375360924 -DTXSID0046567 Css 3compartmentss Human 95% 0.9765 mg/L 0.6245 mg/L 1.56365092073659 -DTXSID0046569 Css 3compartmentss Human 95% 1.061 mg/L 0.7175 mg/L 1.4787456445993 -DTXSID0046640 Css 3compartmentss Human 95% 47.14 mg/L 20.28 mg/L 2.32445759368836 -DTXSID0046642 Css 3compartmentss Human 95% 13.83 mg/L 8.272 mg/L 1.67190522243714 -DTXSID0046644 Css 3compartmentss Human 95% 289.4 mg/L 164 mg/L 1.76463414634146 -DTXSID0046646 Css 3compartmentss Human 95% 11.2 mg/L 6.776 mg/L 1.65289256198347 -DTXSID0046648 Css 3compartmentss Human 95% 2.657 mg/L 0.3949 mg/L 6.72828564193467 -DTXSID0046690 Css 3compartmentss Human 95% 11.51 mg/L 0.09148 mg/L 125.819851333625 -DTXSID0046692 Css 3compartmentss Human 95% 0.7633 mg/L 0.4667 mg/L 1.63552603385472 -DTXSID0046694 Css 3compartmentss Human 95% 4.753 mg/L 3.249 mg/L 1.46291166512773 -DTXSID0046696 Css 3compartmentss Human 95% 1.601 mg/L 0.9087 mg/L 1.76185759876747 -DTXSID0046698 Css 3compartmentss Human 95% 1.074 mg/L 0.561 mg/L 1.9144385026738 -DTXSID0046721 Css 3compartmentss Human 95% 7.732 mg/L 2.682 mg/L 2.88292319164802 -DTXSID0046723 Css 3compartmentss Human 95% 46.43 mg/L 27.26 mg/L 1.70322817314747 -DTXSID0046725 Css 3compartmentss Human 95% 22.83 mg/L 13.04 mg/L 1.75076687116564 -DTXSID0046727 Css 3compartmentss Human 95% 1.959 mg/L 0.9097 mg/L 2.15345718368693 -DTXSID0046729 Css 3compartmentss Human 95% 47.09 mg/L 27.26 mg/L 1.72743947175348 -DTXSID0046773 Css 3compartmentss Human 95% 6.095 mg/L 3.428 mg/L 1.77800466744457 -DTXSID0046777 Css 3compartmentss Human 95% 4.415 mg/L 2.493 mg/L 1.77095868431609 -DTXSID0046779 Css 3compartmentss Human 95% 1.321 mg/L 0.6029 mg/L 2.1910764637585 -DTXSID0046800 Css 3compartmentss Human 95% 11.79 mg/L 7.179 mg/L 1.64229001253656 -DTXSID0046804 Css 3compartmentss Human 95% 15.78 mg/L 7.421 mg/L 2.12639805956071 -DTXSID0046806 Css 3compartmentss Human 95% 3.4 mg/L 1.959e-05 mg/L 173557.937723328 -DTXSID0046808 Css 3compartmentss Human 95% 8.442 mg/L 3.45 mg/L 2.44695652173913 -DTXSID0046850 Css 3compartmentss Human 95% 0.2337 mg/L 0.1701 mg/L 1.37389770723104 -DTXSID0046852 Css 3compartmentss Human 95% 8.897 mg/L 4.147 mg/L 2.14540631782011 -DTXSID0046856 Css 3compartmentss Human 95% 0.2957 mg/L 0.1294 mg/L 2.28516228748068 -DTXSID0046858 Css 3compartmentss Human 95% 1.196 mg/L 1.963e-06 mg/L 609271.523178808 -DTXSID0046989 Css 3compartmentss Human 95% 4.772 mg/L 1.948 mg/L 2.44969199178645 -DTXSID0047030 Css 3compartmentss Human 95% 7.454 mg/L 4.649 mg/L 1.60335556033556 -DTXSID0047036 Css 3compartmentss Human 95% 0.3567 mg/L 0.2548 mg/L 1.39992150706436 -DTXSID0047038 Css 3compartmentss Human 95% 1.014 mg/L 0.6502 mg/L 1.55952014764688 -DTXSID0047084 Css 3compartmentss Human 95% 2.051 mg/L 1.266 mg/L 1.62006319115324 -DTXSID0047111 Css 3compartmentss Human 95% 5.776 mg/L 0.4817 mg/L 11.9908656840357 -DTXSID0047115 Css 3compartmentss Human 95% 10.82 mg/L 6.432 mg/L 1.68221393034826 -DTXSID0047117 Css 3compartmentss Human 95% 33.77 mg/L 62.47 mg/L 0.540579478149512 -DTXSID0047161 Css 3compartmentss Human 95% 0.2485 mg/L 0.173 mg/L 1.4364161849711 -DTXSID0047165 Css 3compartmentss Human 95% 0.3265 mg/L 0.1901 mg/L 1.71751709626512 -DTXSID0047167 Css 3compartmentss Human 95% 3.575 mg/L 3.32 mg/L 1.07680722891566 -DTXSID0047242 Css 3compartmentss Human 95% 0.108 mg/L 0.09712 mg/L 1.11202635914333 -DTXSID0047244 Css 3compartmentss Human 95% 6.774 mg/L 6.306 mg/L 1.07421503330162 -DTXSID0047246 Css 3compartmentss Human 95% 451.4 mg/L 259.7 mg/L 1.73815941470928 -DTXSID0047248 Css 3compartmentss Human 95% 2.58 mg/L 1.356 mg/L 1.90265486725664 -DTXSID0047290 Css 3compartmentss Human 95% 0.116 mg/L 0.06988 mg/L 1.65998855180309 -DTXSID0047294 Css 3compartmentss Human 95% 6.376 mg/L 3.698 mg/L 1.72417522985398 -DTXSID0047296 Css 3compartmentss Human 95% 87.74 mg/L 49.15 mg/L 1.7851475076297 -DTXSID0047325 Css 3compartmentss Human 95% 0.833 mg/L 0.003789 mg/L 219.846925310108 -DTXSID0047327 Css 3compartmentss Human 95% 0.8273 mg/L 0.002189 mg/L 377.935130196437 -DTXSID0047371 Css 3compartmentss Human 95% 1.695 mg/L 0.2266 mg/L 7.4801412180053 -DTXSID0047375 Css 3compartmentss Human 95% 370 mg/L 200.9 mg/L 1.84171229467397 -DTXSID0047377 Css 3compartmentss Human 95% 1.586 mg/L 0.4061 mg/L 3.9054420093573 -DTXSID0047404 Css 3compartmentss Human 95% 1.121 mg/L 0.8263 mg/L 1.35665012707249 -DTXSID0047406 Css 3compartmentss Human 95% 17.22 mg/L 3.414 mg/L 5.04393673110721 -DTXSID0047450 Css 3compartmentss Human 95% 20.65 mg/L 11.98 mg/L 1.7237061769616 -DTXSID0047454 Css 3compartmentss Human 95% 8.522 mg/L 5.487 mg/L 1.55312556952798 -DTXSID0047456 Css 3compartmentss Human 95% 0.6857 mg/L 0.3035 mg/L 2.25930807248764 -DTXSID0047533 Css 3compartmentss Human 95% 0.007269 mg/L 0 mg/L Inf -DTXSID0047535 Css 3compartmentss Human 95% 0.3867 mg/L 0.02355 mg/L 16.4203821656051 -DTXSID0047537 Css 3compartmentss Human 95% 0.006661 mg/L 0 mg/L Inf -DTXSID0047539 Css 3compartmentss Human 95% 5.51 mg/L 1.412 mg/L 3.90226628895184 -DTXSID0047587 Css 3compartmentss Human 95% 2.448 mg/L 2.182 mg/L 1.12190650779102 -DTXSID0047589 Css 3compartmentss Human 95% 4.964 mg/L 3.734 mg/L 1.32940546331012 -DTXSID0047618 Css 3compartmentss Human 95% 5.151 mg/L 3.51 mg/L 1.46752136752137 -DTXSID0047660 Css 3compartmentss Human 95% 3.089 mg/L 2.309 mg/L 1.33780857514075 -DTXSID0047662 Css 3compartmentss Human 95% 1.421 mg/L 0.7263 mg/L 1.95649180779292 -DTXSID0047745 Css 3compartmentss Human 95% 0.9936 mg/L 0.6429 mg/L 1.54549696686888 -DTXSID0047797 Css 3compartmentss Human 95% 4.5 mg/L 3.165 mg/L 1.4218009478673 -DTXSID0047799 Css 3compartmentss Human 95% 1676 mg/L 9739 mg/L 0.172091590512373 -DTXSID0047820 Css 3compartmentss Human 95% 0.2553 mg/L 0.1068 mg/L 2.39044943820225 -DTXSID0047822 Css 3compartmentss Human 95% 0.3718 mg/L 0.2671 mg/L 1.39198801946836 -DTXSID0047828 Css 3compartmentss Human 95% 0.7045 mg/L 0.3689 mg/L 1.90973163458932 -DTXSID0047872 Css 3compartmentss Human 95% 0.2741 mg/L 0.156 mg/L 1.75705128205128 -DTXSID0047876 Css 3compartmentss Human 95% 48.54 mg/L 37.35 mg/L 1.2995983935743 -DTXSID0047878 Css 3compartmentss Human 95% 0.06329 mg/L 0.0418 mg/L 1.51411483253589 -DTXSID0047901 Css 3compartmentss Human 95% 9.973 mg/L 6.206 mg/L 1.60699323235578 -DTXSID0047903 Css 3compartmentss Human 95% 9.973 mg/L 6.206 mg/L 1.60699323235578 -DTXSID0047905 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID0047953 Css 3compartmentss Human 95% 0.00673 mg/L 0 mg/L Inf -DTXSID0047955 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID0047957 Css 3compartmentss Human 95% 3.546 mg/L 0.8835 mg/L 4.01358234295416 -DTXSID0048181 Css 3compartmentss Human 95% 2.039 mg/L 1.167 mg/L 1.74721508140531 -DTXSID0048183 Css 3compartmentss Human 95% 2.798 mg/L 1.287 mg/L 2.17404817404817 -DTXSID0048185 Css 3compartmentss Human 95% 2.933 mg/L 1.63 mg/L 1.79938650306748 -DTXSID0048189 Css 3compartmentss Human 95% 13700 mg/L 7772 mg/L 1.76273803396809 -DTXSID0048210 Css 3compartmentss Human 95% 4.675 mg/L 2.319 mg/L 2.01595515308323 -DTXSID0048349 Css 3compartmentss Human 95% 8.135 mg/L 5.16 mg/L 1.5765503875969 -DTXSID0048505 Css 3compartmentss Human 95% 254.9 mg/L 147.9 mg/L 1.72346179851251 -DTXSID0048507 Css 3compartmentss Human 95% 0.5128 mg/L 0.2818 mg/L 1.81973030518098 -DTXSID0048509 Css 3compartmentss Human 95% 0.7574 mg/L 0.07816 mg/L 9.69037871033777 -DTXSID0048630 Css 3compartmentss Human 95% 0.2211 mg/L 0.1344 mg/L 1.64508928571429 -DTXSID0048632 Css 3compartmentss Human 95% 0.348 mg/L 0.2081 mg/L 1.67227294569918 -DTXSID0048634 Css 3compartmentss Human 95% 1.411 mg/L 0.3635 mg/L 3.88170563961486 -DTXSID0048636 Css 3compartmentss Human 95% 0.00439 mg/L 0 mg/L Inf -DTXSID0048638 Css 3compartmentss Human 95% 3.475 mg/L 2.888 mg/L 1.20325484764543 -DTXSID0048680 Css 3compartmentss Human 95% 11.6 mg/L 7.29 mg/L 1.59122085048011 -DTXSID0048682 Css 3compartmentss Human 95% 0.1276 mg/L 0.08503 mg/L 1.5006468305304 -DTXSID0048684 Css 3compartmentss Human 95% 36.09 mg/L 3.337 mg/L 10.8151033862751 -DTXSID0048686 Css 3compartmentss Human 95% 0.5346 mg/L 0.3768 mg/L 1.4187898089172 -DTXSID0048688 Css 3compartmentss Human 95% 52.44 mg/L 22.99 mg/L 2.28099173553719 -DTXSID0048711 Css 3compartmentss Human 95% 5.625 mg/L 3.628 mg/L 1.55044101433297 -DTXSID0048713 Css 3compartmentss Human 95% 1.511 mg/L 0.8956 mg/L 1.68713711478339 -DTXSID0048715 Css 3compartmentss Human 95% 1.568 mg/L 1.054 mg/L 1.4876660341556 -DTXSID0048717 Css 3compartmentss Human 95% 5.772 mg/L 3.625 mg/L 1.59227586206897 -DTXSID0048719 Css 3compartmentss Human 95% 3.079 mg/L 2.188 mg/L 1.40722120658135 -DTXSID0048761 Css 3compartmentss Human 95% 0.1614 mg/L 0.1128 mg/L 1.43085106382979 -DTXSID0048763 Css 3compartmentss Human 95% 181.3 mg/L 145.1 mg/L 1.24948311509304 -DTXSID0048765 Css 3compartmentss Human 95% 4.124 mg/L 2.551 mg/L 1.61662093296746 -DTXSID0048767 Css 3compartmentss Human 95% 0.9807 mg/L 0.254 mg/L 3.86102362204724 -DTXSID0048769 Css 3compartmentss Human 95% 0.4296 mg/L 0.1142 mg/L 3.76182136602452 -DTXSID0048840 Css 3compartmentss Human 95% 0.03712 mg/L 0.02731 mg/L 1.35920908092274 -DTXSID0048842 Css 3compartmentss Human 95% 0.8038 mg/L 0.004435 mg/L 181.240135287486 -DTXSID0048844 Css 3compartmentss Human 95% 5.366 mg/L 2.902 mg/L 1.84906960716747 -DTXSID0048846 Css 3compartmentss Human 95% 5.107 mg/L 0.5604 mg/L 9.11313347608851 -DTXSID0048848 Css 3compartmentss Human 95% 0.4206 mg/L 0.264 mg/L 1.59318181818182 -DTXSID0048890 Css 3compartmentss Human 95% 0.008528 mg/L 0.006484 mg/L 1.31523750771129 -DTXSID0048892 Css 3compartmentss Human 95% 0.08431 mg/L 0.0594 mg/L 1.41936026936027 -DTXSID0048894 Css 3compartmentss Human 95% 0.5074 mg/L 0.3411 mg/L 1.48754031075931 -DTXSID0048896 Css 3compartmentss Human 95% 1.004 mg/L 0.6368 mg/L 1.57663316582915 -DTXSID0048898 Css 3compartmentss Human 95% 6.264 mg/L 3.551 mg/L 1.7640101379893 -DTXSID0048921 Css 3compartmentss Human 95% 1.304 mg/L 0.9619 mg/L 1.35565027549641 -DTXSID0048923 Css 3compartmentss Human 95% 7.38 mg/L 1.039 mg/L 7.10298363811357 -DTXSID0048925 Css 3compartmentss Human 95% 1.347 mg/L 0.06223 mg/L 21.6455085971396 -DTXSID0048927 Css 3compartmentss Human 95% 0.4878 mg/L 0.2645 mg/L 1.84423440453686 -DTXSID0048929 Css 3compartmentss Human 95% 9.571 mg/L 3.068 mg/L 3.11962190352021 -DTXSID0048971 Css 3compartmentss Human 95% 2.271 mg/L 1.177 mg/L 1.92948173322005 -DTXSID0048973 Css 3compartmentss Human 95% 6.967 mg/L 3.283 mg/L 2.12214438014012 -DTXSID0048975 Css 3compartmentss Human 95% 7.923 mg/L 4.978 mg/L 1.59160305343511 -DTXSID0048977 Css 3compartmentss Human 95% 0.1059 mg/L 0.04622 mg/L 2.29121592384249 -DTXSID0048979 Css 3compartmentss Human 95% 1.623 mg/L 1.182 mg/L 1.37309644670051 -DTXSID0049020 Css 3compartmentss Human 95% 2.723 mg/L 2.077 mg/L 1.31102551757342 -DTXSID0049022 Css 3compartmentss Human 95% 0.3259 mg/L 0.2072 mg/L 1.57287644787645 -DTXSID0049024 Css 3compartmentss Human 95% 1.587 mg/L 1.615 mg/L 0.98266253869969 -DTXSID0049026 Css 3compartmentss Human 95% 17.98 mg/L 10.94 mg/L 1.64351005484461 -DTXSID0049028 Css 3compartmentss Human 95% 0.127 mg/L 0.07861 mg/L 1.61557053809948 -DTXSID0049070 Css 3compartmentss Human 95% 0.5748 mg/L 0.4208 mg/L 1.36596958174905 -DTXSID0049072 Css 3compartmentss Human 95% 0.6429 mg/L 0.4713 mg/L 1.36409929980904 -DTXSID0049074 Css 3compartmentss Human 95% 1.206 mg/L 1.016 mg/L 1.18700787401575 -DTXSID0049076 Css 3compartmentss Human 95% 195.5 mg/L 101.7 mg/L 1.92232055063913 -DTXSID0049078 Css 3compartmentss Human 95% 109.6 mg/L 38.81 mg/L 2.82401442927081 -DTXSID0049234 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID0049280 Css 3compartmentss Human 95% 0.1482 mg/L 0 mg/L Inf -DTXSID0049286 Css 3compartmentss Human 95% 0.2741 mg/L 0.156 mg/L 1.75705128205128 -DTXSID0049288 Css 3compartmentss Human 95% 1.201 mg/L 0.9754 mg/L 1.23128972729137 -DTXSID0049311 Css 3compartmentss Human 95% 2.361 mg/L 1.213 mg/L 1.94641384995878 -DTXSID0049313 Css 3compartmentss Human 95% 4.478 mg/L 2.815 mg/L 1.59076376554174 -DTXSID0049315 Css 3compartmentss Human 95% 4.11 mg/L 2.266 mg/L 1.81376875551633 -DTXSID0049361 Css 3compartmentss Human 95% 5.578 mg/L 3.554 mg/L 1.5694991558807 -DTXSID0049365 Css 3compartmentss Human 95% 7.87 mg/L 4.913 mg/L 1.60187258294321 -DTXSID0050423 Css 3compartmentss Human 95% 49.36 mg/L 28.92 mg/L 1.70677731673582 -DTXSID0050425 Css 3compartmentss Human 95% 5.708 mg/L 3.662 mg/L 1.55871108683779 -DTXSID0051447 Css 3compartmentss Human 95% 0.646 mg/L 0.2658 mg/L 2.43039879608728 -DTXSID0051493 Css 3compartmentss Human 95% 2.335 mg/L 1.57 mg/L 1.48726114649682 -DTXSID0051497 Css 3compartmentss Human 95% 5.417 mg/L 6.208 mg/L 0.872583762886598 -DTXSID0051499 Css 3compartmentss Human 95% 1.063 mg/L 0.7264 mg/L 1.46338105726872 -DTXSID0051732 Css 3compartmentss Human 95% 1.289 mg/L 1.15 mg/L 1.12086956521739 -DTXSID0051738 Css 3compartmentss Human 95% 29.17 mg/L 50.17 mg/L 0.581423161251744 -DTXSID0051782 Css 3compartmentss Human 95% 2.082 mg/L 1.311 mg/L 1.58810068649886 -DTXSID0051863 Css 3compartmentss Human 95% 0.1298 mg/L 0.0811 mg/L 1.60049321824908 -DTXSID0051944 Css 3compartmentss Human 95% 4.78 mg/L 3.226 mg/L 1.48171109733416 -DTXSID0051996 Css 3compartmentss Human 95% 0.9186 mg/L 0.6456 mg/L 1.4228624535316 -DTXSID0052043 Css 3compartmentss Human 95% 2.899 mg/L 1.854 mg/L 1.56364617044229 -DTXSID0052124 Css 3compartmentss Human 95% 2.197 mg/L 1.474 mg/L 1.49050203527815 -DTXSID0052463 Css 3compartmentss Human 95% 6.782 mg/L 3.513 mg/L 1.93054369484771 -DTXSID0052542 Css 3compartmentss Human 95% 5.179 mg/L 3.707 mg/L 1.39708659293229 -DTXSID0052594 Css 3compartmentss Human 95% 0.8758 mg/L 0.5444 mg/L 1.60874357090375 -DTXSID0052596 Css 3compartmentss Human 95% 0.4458 mg/L 0.2452 mg/L 1.81810766721044 -DTXSID0052598 Css 3compartmentss Human 95% 4.137 mg/L 2.565 mg/L 1.61286549707602 -DTXSID0052833 Css 3compartmentss Human 95% 5.557 mg/L 3.628 mg/L 1.53169790518192 -DTXSID0052837 Css 3compartmentss Human 95% 2.239 mg/L 1.239 mg/L 1.80710250201776 -DTXSID0052839 Css 3compartmentss Human 95% 4.937 mg/L 3.115 mg/L 1.58491171749599 -DTXSID0057621 Css 3compartmentss Human 95% 1.333 mg/L 0.8568 mg/L 1.55578898225957 -DTXSID0057625 Css 3compartmentss Human 95% 0.6524 mg/L 0.04029 mg/L 16.192603623728 -DTXSID0057627 Css 3compartmentss Human 95% 0.8986 mg/L 0.2173 mg/L 4.13529682466636 -DTXSID0057629 Css 3compartmentss Human 95% 1.016 mg/L 0.5984 mg/L 1.69786096256684 -DTXSID0057671 Css 3compartmentss Human 95% 2.722 mg/L 1.169 mg/L 2.32848588537211 -DTXSID0057673 Css 3compartmentss Human 95% 94.82 mg/L 51.17 mg/L 1.85303888997459 -DTXSID0057677 Css 3compartmentss Human 95% 11.34 mg/L 0.3454 mg/L 32.8314997104806 -DTXSID0057679 Css 3compartmentss Human 95% 0.318 mg/L 0.2298 mg/L 1.38381201044386 -DTXSID0057700 Css 3compartmentss Human 95% 0.928 mg/L 0.6897 mg/L 1.34551254168479 -DTXSID0057702 Css 3compartmentss Human 95% 6.861 mg/L 3.768 mg/L 1.82085987261147 -DTXSID0057704 Css 3compartmentss Human 95% 2.028 mg/L 2.249 mg/L 0.901734104046243 -DTXSID0057706 Css 3compartmentss Human 95% 20.29 mg/L 9.743 mg/L 2.08252078415272 -DTXSID0057708 Css 3compartmentss Human 95% 1.36 mg/L 1.077 mg/L 1.2627669452182 -DTXSID0057750 Css 3compartmentss Human 95% 119.9 mg/L 61.29 mg/L 1.95627345407081 -DTXSID0057754 Css 3compartmentss Human 95% 8.93 mg/L 5.457 mg/L 1.6364302730438 -DTXSID0057756 Css 3compartmentss Human 95% 0.01516 mg/L 6.242e-05 mg/L 242.870874719641 -DTXSID0057758 Css 3compartmentss Human 95% 4.282 mg/L 1.037 mg/L 4.12921890067502 -DTXSID0057831 Css 3compartmentss Human 95% 7.461 mg/L 4.063 mg/L 1.83632783657396 -DTXSID0057833 Css 3compartmentss Human 95% 0.2208 mg/L 0.1434 mg/L 1.5397489539749 -DTXSID0057835 Css 3compartmentss Human 95% 0.3924 mg/L 0.2387 mg/L 1.64390448261416 -DTXSID0057837 Css 3compartmentss Human 95% 23.23 mg/L 13.35 mg/L 1.74007490636704 -DTXSID0057839 Css 3compartmentss Human 95% 2.401 mg/L 1.326 mg/L 1.81070889894419 -DTXSID00859151 Css 3compartmentss Human 95% 12.12 mg/L 7.496 mg/L 1.61686232657417 -DTXSID00872663 Css 3compartmentss Human 95% 119.5 mg/L 48.58 mg/L 2.45986002470152 -DTXSID00904978 Css 3compartmentss Human 95% 1.823 mg/L 1.006 mg/L 1.81212723658052 -DTXSID101017364 Css 3compartmentss Human 95% 1.407 mg/L 1.006 mg/L 1.3986083499006 -DTXSID10198927 Css 3compartmentss Human 95% 0.2893 mg/L 0.1691 mg/L 1.71082199881727 -DTXSID1020015 Css 3compartmentss Human 95% 1.957 mg/L 1.445 mg/L 1.35432525951557 -DTXSID1020063 Css 3compartmentss Human 95% 1.337 mg/L 1.032 mg/L 1.29554263565891 -DTXSID1020069 Css 3compartmentss Human 95% 78.02 mg/L 26.69 mg/L 2.92319220681903 -DTXSID1020140 Css 3compartmentss Human 95% 16.23 mg/L 9.891 mg/L 1.64088565362451 -DTXSID1020142 Css 3compartmentss Human 95% 2.53 mg/L 1.595 mg/L 1.58620689655172 -DTXSID1020144 Css 3compartmentss Human 95% 4.388 mg/L 2.427 mg/L 1.80799340749897 -DTXSID1020146 Css 3compartmentss Human 95% 7.226 mg/L 1.23 mg/L 5.87479674796748 -DTXSID1020190 Css 3compartmentss Human 95% 16.02 mg/L 9.839 mg/L 1.62821424941559 -DTXSID1020194 Css 3compartmentss Human 95% 8.889 mg/L 5.51 mg/L 1.61324863883848 -DTXSID1020221 Css 3compartmentss Human 95% 1.584 mg/L 1.674 mg/L 0.946236559139785 -DTXSID1020223 Css 3compartmentss Human 95% 5.584 mg/L 3.744 mg/L 1.49145299145299 -DTXSID1020275 Css 3compartmentss Human 95% 2.393 mg/L 0.8918 mg/L 2.68333707109217 -DTXSID1020308 Css 3compartmentss Human 95% 1.868 mg/L 1.17 mg/L 1.5965811965812 -DTXSID1020350 Css 3compartmentss Human 95% 0.4467 mg/L 0.3009 mg/L 1.48454636091725 -DTXSID1020352 Css 3compartmentss Human 95% 14.15 mg/L 8.49 mg/L 1.66666666666667 -DTXSID1020354 Css 3compartmentss Human 95% 5.748 mg/L 3.804 mg/L 1.51104100946372 -DTXSID1020358 Css 3compartmentss Human 95% 5.726 mg/L 3.63 mg/L 1.57741046831956 -DTXSID1020433 Css 3compartmentss Human 95% 1.001 mg/L 0.4504 mg/L 2.22246891651865 -DTXSID1020439 Css 3compartmentss Human 95% 2.467 mg/L 2.418 mg/L 1.020264681555 -DTXSID1020483 Css 3compartmentss Human 95% 0.05109 mg/L 0.03354 mg/L 1.52325581395349 -DTXSID1020485 Css 3compartmentss Human 95% 2.693 mg/L 1.712 mg/L 1.57301401869159 -DTXSID1020510 Css 3compartmentss Human 95% 137.2 mg/L 0.1624 mg/L 844.827586206897 -DTXSID1020512 Css 3compartmentss Human 95% 4.819 mg/L 3.274 mg/L 1.47189981673794 -DTXSID1020516 Css 3compartmentss Human 95% 6.62 mg/L 3.928 mg/L 1.68533604887984 -DTXSID1020560 Css 3compartmentss Human 95% 145.2 mg/L 278.2 mg/L 0.521926671459382 -DTXSID1020647 Css 3compartmentss Human 95% 1.216 mg/L 0.8057 mg/L 1.50924661784783 -DTXSID1020697 Css 3compartmentss Human 95% 2.576 mg/L 0.06426 mg/L 40.0871459694989 -DTXSID1020699 Css 3compartmentss Human 95% 2.012 mg/L 1.231 mg/L 1.63444354183591 -DTXSID1020728 Css 3compartmentss Human 95% 5.911 mg/L 3.753 mg/L 1.5750066613376 -DTXSID1020803 Css 3compartmentss Human 95% 624.5 mg/L 433.7 mg/L 1.43993543924372 -DTXSID1020805 Css 3compartmentss Human 95% 6.845 mg/L 6.914 mg/L 0.99002024877061 -DTXSID1020807 Css 3compartmentss Human 95% 5.23 mg/L 2.856 mg/L 1.8312324929972 -DTXSID1020809 Css 3compartmentss Human 95% 7.793 mg/L 4.877 mg/L 1.59790855033832 -DTXSID1020855 Css 3compartmentss Human 95% 14.65 mg/L 6.511 mg/L 2.25003839655967 -DTXSID1020857 Css 3compartmentss Human 95% 0.9896 mg/L 0.7018 mg/L 1.41008834425762 -DTXSID1020859 Css 3compartmentss Human 95% 2.278 mg/L 1.439 mg/L 1.58304378040306 -DTXSID1020930 Css 3compartmentss Human 95% 0.9639 mg/L 0.6945 mg/L 1.38790496760259 -DTXSID1020932 Css 3compartmentss Human 95% 0.7551 mg/L 0.526 mg/L 1.43555133079848 -DTXSID1020982 Css 3compartmentss Human 95% 8.78 mg/L 5.371 mg/L 1.63470489666729 -DTXSID1020984 Css 3compartmentss Human 95% 1.707 mg/L 1.051 mg/L 1.62416745956232 -DTXSID1021031 Css 3compartmentss Human 95% 0.05076 mg/L 0.02525 mg/L 2.01029702970297 -DTXSID1021039 Css 3compartmentss Human 95% 3.483 mg/L 2.442 mg/L 1.42628992628993 -DTXSID1021081 Css 3compartmentss Human 95% 365 mg/L 196.9 mg/L 1.85373285931945 -DTXSID1021087 Css 3compartmentss Human 95% 31.95 mg/L 16.31 mg/L 1.95892090741876 -DTXSID1021089 Css 3compartmentss Human 95% 23.94 mg/L 13.72 mg/L 1.74489795918367 -DTXSID1021114 Css 3compartmentss Human 95% 0.05903 mg/L 3e-09 mg/L 19676666.6666667 -DTXSID1021116 Css 3compartmentss Human 95% 0.6744 mg/L 0.4069 mg/L 1.65740968296879 -DTXSID1021118 Css 3compartmentss Human 95% 5.555 mg/L 3.003 mg/L 1.84981684981685 -DTXSID1021160 Css 3compartmentss Human 95% 9.622 mg/L 6.065 mg/L 1.58647980214345 -DTXSID1021162 Css 3compartmentss Human 95% 1.416 mg/L 0.8297 mg/L 1.70664095456189 -DTXSID1021164 Css 3compartmentss Human 95% 1.415 mg/L 0.9424 mg/L 1.50148556876061 -DTXSID1021166 Css 3compartmentss Human 95% 3.788 mg/L 0.2874 mg/L 13.1802366040362 -DTXSID1021168 Css 3compartmentss Human 95% 19.08 mg/L 0.5258 mg/L 36.2875618105744 -DTXSID1021241 Css 3compartmentss Human 95% 0.0001562 mg/L 0 mg/L Inf -DTXSID1021243 Css 3compartmentss Human 95% 925.7 mg/L 545.5 mg/L 1.69697525206233 -DTXSID1021247 Css 3compartmentss Human 95% 3.186 mg/L 2.017 mg/L 1.57957362419435 -DTXSID1021291 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID1021299 Css 3compartmentss Human 95% 8257 mg/L 5280 mg/L 1.56382575757576 -DTXSID1021320 Css 3compartmentss Human 95% 0.9488 mg/L 0.2785 mg/L 3.40682226211849 -DTXSID1021322 Css 3compartmentss Human 95% 1.439 mg/L 0.2594 mg/L 5.54741711642251 -DTXSID1021372 Css 3compartmentss Human 95% 0.3693 mg/L 0.2202 mg/L 1.67711171662125 -DTXSID1021378 Css 3compartmentss Human 95% 10.35 mg/L 6.6 mg/L 1.56818181818182 -DTXSID1021403 Css 3compartmentss Human 95% 5.784 mg/L 3.883 mg/L 1.48956992016482 -DTXSID1021405 Css 3compartmentss Human 95% 8.656 mg/L 4.135 mg/L 2.09334945586457 -DTXSID1021409 Css 3compartmentss Human 95% 2614 mg/L 4061 mg/L 0.643683821718788 -DTXSID1021455 Css 3compartmentss Human 95% 22.03 mg/L 11.3 mg/L 1.94955752212389 -DTXSID1021530 Css 3compartmentss Human 95% 4.294 mg/L 3.507 mg/L 1.22440832620473 -DTXSID1021615 Css 3compartmentss Human 95% 3.129 mg/L 2.199 mg/L 1.42291950886767 -DTXSID1021617 Css 3compartmentss Human 95% 38.68 mg/L 22.61 mg/L 1.71074745687749 -DTXSID1021667 Css 3compartmentss Human 95% 18.9 mg/L 28.73 mg/L 0.657848938391925 -DTXSID1021740 Css 3compartmentss Human 95% 5.785 mg/L 4.084 mg/L 1.41650342801175 -DTXSID1021744 Css 3compartmentss Human 95% 11.22 mg/L 7.226 mg/L 1.55272626626073 -DTXSID1021790 Css 3compartmentss Human 95% 12.55 mg/L 7.965 mg/L 1.57564344005022 -DTXSID1021792 Css 3compartmentss Human 95% 0.8153 mg/L 0.4593 mg/L 1.77509253211409 -DTXSID1021798 Css 3compartmentss Human 95% 0.4753 mg/L 0.2928 mg/L 1.62329234972678 -DTXSID1021821 Css 3compartmentss Human 95% 5.319 mg/L 3.591 mg/L 1.4812030075188 -DTXSID1021823 Css 3compartmentss Human 95% 5.706 mg/L 3.565 mg/L 1.60056100981767 -DTXSID1021871 Css 3compartmentss Human 95% 1.67 mg/L 1.277 mg/L 1.30775254502741 -DTXSID1021877 Css 3compartmentss Human 95% 5.587 mg/L 3.63 mg/L 1.53911845730028 -DTXSID1021904 Css 3compartmentss Human 95% 3.482 mg/L 2.418 mg/L 1.44003308519438 -DTXSID1021952 Css 3compartmentss Human 95% 30.62 mg/L 1.884 mg/L 16.2526539278132 -DTXSID1021956 Css 3compartmentss Human 95% 656.1 mg/L 9739 mg/L 0.0673683129684773 -DTXSID1021958 Css 3compartmentss Human 95% 0.8027 mg/L 0.7179 mg/L 1.11812230115615 -DTXSID1022009 Css 3compartmentss Human 95% 0.01883 mg/L 9.029e-05 mg/L 208.550227046184 -DTXSID1022051 Css 3compartmentss Human 95% 1.988 mg/L 1.351 mg/L 1.47150259067358 -DTXSID1022053 Css 3compartmentss Human 95% 1992 mg/L 1151 mg/L 1.73066898349262 -DTXSID1022138 Css 3compartmentss Human 95% 4.313 mg/L 2.982 mg/L 1.44634473507713 -DTXSID1022180 Css 3compartmentss Human 95% 6.845 mg/L 6.914 mg/L 0.99002024877061 -DTXSID1022217 Css 3compartmentss Human 95% 0.01418 mg/L 0.008974 mg/L 1.58012034767105 -DTXSID1022265 Css 3compartmentss Human 95% 1.158 mg/L 0.7533 mg/L 1.53723616089207 -DTXSID1022267 Css 3compartmentss Human 95% 0.8153 mg/L 0.6191 mg/L 1.31691164593765 -DTXSID1022394 Css 3compartmentss Human 95% 0.8213 mg/L 0.3604 mg/L 2.27885682574917 -DTXSID1022396 Css 3compartmentss Human 95% 10.95 mg/L 4.949 mg/L 2.21256819559507 -DTXSID1022421 Css 3compartmentss Human 95% 3.904 mg/L 2.721 mg/L 1.43476662991547 -DTXSID1022425 Css 3compartmentss Human 95% 6.828 mg/L 3.568 mg/L 1.91367713004484 -DTXSID1022479 Css 3compartmentss Human 95% 1.405 mg/L 1.058 mg/L 1.32797731568998 -DTXSID1022508 Css 3compartmentss Human 95% 0.451 mg/L 2e-09 mg/L 225500000 -DTXSID1022556 Css 3compartmentss Human 95% 0.2936 mg/L 0.2079 mg/L 1.41221741221741 -DTXSID1022558 Css 3compartmentss Human 95% 5.484 mg/L 3.612 mg/L 1.51827242524917 -DTXSID1022635 Css 3compartmentss Human 95% 5.613 mg/L 3.462 mg/L 1.62131715771231 -DTXSID1022681 Css 3compartmentss Human 95% 3.103 mg/L 0.7414 mg/L 4.18532506069598 -DTXSID1022683 Css 3compartmentss Human 95% 3.074 mg/L 0.1161 mg/L 26.4771748492679 -DTXSID1022687 Css 3compartmentss Human 95% 0.1155 mg/L 0.07347 mg/L 1.57207023274806 -DTXSID1022718 Css 3compartmentss Human 95% 0.4406 mg/L 0.5079 mg/L 0.867493601102579 -DTXSID1022760 Css 3compartmentss Human 95% 14.93 mg/L 9.338 mg/L 1.59884343542514 -DTXSID1022762 Css 3compartmentss Human 95% 27.21 mg/L 16.15 mg/L 1.68482972136223 -DTXSID1022764 Css 3compartmentss Human 95% 3.007 mg/L 1.787 mg/L 1.68270844991606 -DTXSID1022766 Css 3compartmentss Human 95% 0.07466 mg/L 0.04381 mg/L 1.70417712850947 -DTXSID1022768 Css 3compartmentss Human 95% 25.32 mg/L 14.8 mg/L 1.71081081081081 -DTXSID1022843 Css 3compartmentss Human 95% 0.392 mg/L 0.0005001 mg/L 783.843231353729 -DTXSID1022845 Css 3compartmentss Human 95% 1.136 mg/L 0.9376 mg/L 1.21160409556314 -DTXSID1022847 Css 3compartmentss Human 95% 1.552 mg/L 0.9568 mg/L 1.62207357859532 -DTXSID1022897 Css 3compartmentss Human 95% 11.63 mg/L 7.335 mg/L 1.58554873892297 -DTXSID1022922 Css 3compartmentss Human 95% 22.86 mg/L 14.1 mg/L 1.62127659574468 -DTXSID1022926 Css 3compartmentss Human 95% 0.6999 mg/L 0.06209 mg/L 11.2723465936544 -DTXSID1022974 Css 3compartmentss Human 95% 16.56 mg/L 11.45 mg/L 1.44628820960699 -DTXSID1022978 Css 3compartmentss Human 95% 3.034 mg/L 2.364 mg/L 1.2834179357022 -DTXSID1023021 Css 3compartmentss Human 95% 8.47 mg/L 5.002 mg/L 1.69332267093163 -DTXSID1023027 Css 3compartmentss Human 95% 2.695 mg/L 1.208 mg/L 2.23096026490066 -DTXSID1023071 Css 3compartmentss Human 95% 5.103 mg/L 3.086 mg/L 1.65359688917693 -DTXSID1023102 Css 3compartmentss Human 95% 2.949 mg/L 1.926 mg/L 1.53115264797508 -DTXSID1023150 Css 3compartmentss Human 95% 4.692 mg/L 2.593 mg/L 1.80948708060162 -DTXSID1023158 Css 3compartmentss Human 95% 5.669 mg/L 3.628 mg/L 1.56256890848953 -DTXSID1023231 Css 3compartmentss Human 95% 7.219 mg/L 4.165 mg/L 1.73325330132053 -DTXSID1023235 Css 3compartmentss Human 95% 5.588 mg/L 3.628 mg/L 1.54024255788313 -DTXSID1023239 Css 3compartmentss Human 95% 7.61 mg/L 4.991 mg/L 1.52474454017231 -DTXSID1023281 Css 3compartmentss Human 95% 4.467 mg/L 2.661 mg/L 1.67869222096956 -DTXSID1023287 Css 3compartmentss Human 95% 13.25 mg/L 10.11 mg/L 1.31058358061325 -DTXSID1023310 Css 3compartmentss Human 95% 7.966 mg/L 4.851 mg/L 1.64213564213564 -DTXSID1023314 Css 3compartmentss Human 95% 4.119 mg/L 3.404 mg/L 1.21004700352526 -DTXSID1023316 Css 3compartmentss Human 95% 2.241 mg/L 1.281 mg/L 1.74941451990632 -DTXSID1023362 Css 3compartmentss Human 95% 1.193 mg/L 0.7207 mg/L 1.65533509088386 -DTXSID1023364 Css 3compartmentss Human 95% 0.1414 mg/L 0.06126 mg/L 2.30819458047666 -DTXSID1023368 Css 3compartmentss Human 95% 1094 mg/L 651 mg/L 1.68049155145929 -DTXSID1023441 Css 3compartmentss Human 95% 3.097 mg/L 0.9578 mg/L 3.23345166005429 -DTXSID1023495 Css 3compartmentss Human 95% 1.427 mg/L 0.7391 mg/L 1.93072655932891 -DTXSID1023497 Css 3compartmentss Human 95% 222.8 mg/L 124.3 mg/L 1.79243765084473 -DTXSID1023524 Css 3compartmentss Human 95% 0.4139 mg/L 0.09492 mg/L 4.36051411715129 -DTXSID1023572 Css 3compartmentss Human 95% 83.76 mg/L 43.37 mg/L 1.93128890938437 -DTXSID1023576 Css 3compartmentss Human 95% 92.26 mg/L 52.95 mg/L 1.7423984891407 -DTXSID1023603 Css 3compartmentss Human 95% 1.152 mg/L 0.8535 mg/L 1.34973637961336 -DTXSID1023605 Css 3compartmentss Human 95% 1.737 mg/L 1.018 mg/L 1.70628683693517 -DTXSID1023607 Css 3compartmentss Human 95% 7.093 mg/L 3.889 mg/L 1.82386217536642 -DTXSID1023609 Css 3compartmentss Human 95% 0.09447 mg/L 0.05049 mg/L 1.87106357694593 -DTXSID1023730 Css 3compartmentss Human 95% 5.577 mg/L 3.628 mg/L 1.53721058434399 -DTXSID1023734 Css 3compartmentss Human 95% 8.499 mg/L 5.239 mg/L 1.62225615575492 -DTXSID1023736 Css 3compartmentss Human 95% 1737 mg/L 6022 mg/L 0.288442377947526 -DTXSID1023815 Css 3compartmentss Human 95% 7.489 mg/L 4.97 mg/L 1.50684104627767 -DTXSID1023819 Css 3compartmentss Human 95% 1.487 mg/L 0.9389 mg/L 1.58376823942912 -DTXSID1023869 Css 3compartmentss Human 95% 39.67 mg/L 14.55 mg/L 2.72646048109966 -DTXSID1023990 Css 3compartmentss Human 95% 11.2 mg/L 9.313 mg/L 1.20261999355739 -DTXSID1023996 Css 3compartmentss Human 95% 2.085 mg/L 1.363 mg/L 1.52971386647102 -DTXSID1023998 Css 3compartmentss Human 95% 5.689 mg/L 5.778e-05 mg/L 98459.6746278989 -DTXSID1024045 Css 3compartmentss Human 95% 6.49 mg/L 4.497 mg/L 1.44318434511897 -DTXSID1024049 Css 3compartmentss Human 95% 211.4 mg/L 132.4 mg/L 1.59667673716012 -DTXSID1024091 Css 3compartmentss Human 95% 0.4549 mg/L 0.3522 mg/L 1.2915956842703 -DTXSID1024097 Css 3compartmentss Human 95% 0.9198 mg/L 0.6332 mg/L 1.45262160454833 -DTXSID1024124 Css 3compartmentss Human 95% 6.513 mg/L 3.635 mg/L 1.79174690508941 -DTXSID1024126 Css 3compartmentss Human 95% 1940 mg/L 3594 mg/L 0.539788536449638 -DTXSID1024174 Css 3compartmentss Human 95% 3.638 mg/L 0.006769 mg/L 537.450140345694 -DTXSID1024176 Css 3compartmentss Human 95% 5.691 mg/L 3.838 mg/L 1.48280354351225 -DTXSID1024209 Css 3compartmentss Human 95% 24.65 mg/L 14.88 mg/L 1.65658602150538 -DTXSID1024255 Css 3compartmentss Human 95% 8.268 mg/L 3.2 mg/L 2.58375 -DTXSID1024259 Css 3compartmentss Human 95% 14.71 mg/L 2.97 mg/L 4.95286195286195 -DTXSID1024334 Css 3compartmentss Human 95% 18.35 mg/L 27.08 mg/L 0.677621861152142 -DTXSID1024338 Css 3compartmentss Human 95% 2.053 mg/L 1.259 mg/L 1.6306592533757 -DTXSID1024413 Css 3compartmentss Human 95% 3.786 mg/L 2.309 mg/L 1.6396708531832 -DTXSID1024463 Css 3compartmentss Human 95% 7.549 mg/L 4.696 mg/L 1.60753833049404 -DTXSID1024465 Css 3compartmentss Human 95% 2.927 mg/L 1.934 mg/L 1.5134436401241 -DTXSID1024467 Css 3compartmentss Human 95% 2.186 mg/L 1.508 mg/L 1.44960212201591 -DTXSID1024598 Css 3compartmentss Human 95% 16.15 mg/L 6.797 mg/L 2.37604825658379 -DTXSID1024621 Css 3compartmentss Human 95% 5.177 mg/L 3.319 mg/L 1.55980717083459 -DTXSID1024625 Css 3compartmentss Human 95% 10.89 mg/L 0.1911 mg/L 56.9858712715856 -DTXSID1024629 Css 3compartmentss Human 95% 1.13 mg/L 0.1242 mg/L 9.09822866344605 -DTXSID1024831 Css 3compartmentss Human 95% 8.387 mg/L 5.175 mg/L 1.62067632850242 -DTXSID1024881 Css 3compartmentss Human 95% 4.9 mg/L 2.336 mg/L 2.09760273972603 -DTXSID1024885 Css 3compartmentss Human 95% 8.074 mg/L 3.713 mg/L 2.17452194990574 -DTXSID1024887 Css 3compartmentss Human 95% 21.27 mg/L 0.9742 mg/L 21.8332991172244 -DTXSID1024916 Css 3compartmentss Human 95% 1.526 mg/L 1.036 mg/L 1.47297297297297 -DTXSID1024918 Css 3compartmentss Human 95% 2.772 mg/L 1.938 mg/L 1.43034055727554 -DTXSID1024966 Css 3compartmentss Human 95% 3.032 mg/L 2.633 mg/L 1.15153816938853 -DTXSID1025013 Css 3compartmentss Human 95% 9.275 mg/L 5.471 mg/L 1.69530250411259 -DTXSID1025063 Css 3compartmentss Human 95% 5.031 mg/L 3.483 mg/L 1.44444444444444 -DTXSID1025065 Css 3compartmentss Human 95% 15.9 mg/L 9.532 mg/L 1.66806546370122 -DTXSID1025148 Css 3compartmentss Human 95% 1.362 mg/L 1.006 mg/L 1.35387673956262 -DTXSID1025271 Css 3compartmentss Human 95% 0.6476 mg/L 0.3955 mg/L 1.63742098609355 -DTXSID1025279 Css 3compartmentss Human 95% 3.361 mg/L 3.861 mg/L 0.870499870499871 -DTXSID1025302 Css 3compartmentss Human 95% 6.293 mg/L 0.09966 mg/L 63.144691952639 -DTXSID1025304 Css 3compartmentss Human 95% 0.09833 mg/L 0.03881 mg/L 2.53362535429013 -DTXSID1025431 Css 3compartmentss Human 95% 4.63 mg/L 2.869 mg/L 1.61380271871732 -DTXSID1025433 Css 3compartmentss Human 95% 6.129 mg/L 3.932 mg/L 1.5587487283825 -DTXSID1025437 Css 3compartmentss Human 95% 5.713 mg/L 3.443 mg/L 1.65930874237584 -DTXSID1025485 Css 3compartmentss Human 95% 5.9 mg/L 2.609 mg/L 2.26140283633576 -DTXSID1025512 Css 3compartmentss Human 95% 0.3761 mg/L 0.00862 mg/L 43.631090487239 -DTXSID1025560 Css 3compartmentss Human 95% 2.737 mg/L 1.468 mg/L 1.86444141689373 -DTXSID1025641 Css 3compartmentss Human 95% 19.4 mg/L 11.04 mg/L 1.75724637681159 -DTXSID1025693 Css 3compartmentss Human 95% 0.03563 mg/L 0.02185 mg/L 1.63066361556064 -DTXSID1025722 Css 3compartmentss Human 95% 5.271 mg/L 3.333 mg/L 1.58145814581458 -DTXSID1025724 Css 3compartmentss Human 95% 1.591 mg/L 1.002 mg/L 1.58782435129741 -DTXSID1025726 Css 3compartmentss Human 95% 2.763 mg/L 1.675 mg/L 1.64955223880597 -DTXSID1025770 Css 3compartmentss Human 95% 0.1669 mg/L 0.112 mg/L 1.49017857142857 -DTXSID1025774 Css 3compartmentss Human 95% 11.07 mg/L 6.762 mg/L 1.63708961845608 -DTXSID1025776 Css 3compartmentss Human 95% 11.62 mg/L 7.22 mg/L 1.60941828254848 -DTXSID1025807 Css 3compartmentss Human 95% 67.96 mg/L 32.89 mg/L 2.06628154454241 -DTXSID1025809 Css 3compartmentss Human 95% 637.8 mg/L 7648 mg/L 0.0833943514644351 -DTXSID1025853 Css 3compartmentss Human 95% 9.151 mg/L 5.827 mg/L 1.57044791487901 -DTXSID1025930 Css 3compartmentss Human 95% 36.58 mg/L 19.02 mg/L 1.92323869610936 -DTXSID1025934 Css 3compartmentss Human 95% 5.825 mg/L 3.853 mg/L 1.51180898001557 -DTXSID1026031 Css 3compartmentss Human 95% 74.8 mg/L 38.27 mg/L 1.95453357721453 -DTXSID1026033 Css 3compartmentss Human 95% 2.845 mg/L 1.692 mg/L 1.68144208037825 -DTXSID1026035 Css 3compartmentss Human 95% 2.885 mg/L 1.591 mg/L 1.81332495285984 -DTXSID1026081 Css 3compartmentss Human 95% 9.161 mg/L 0.03256 mg/L 281.357493857494 -DTXSID1026083 Css 3compartmentss Human 95% 45.75 mg/L 85.25 mg/L 0.536656891495601 -DTXSID1026112 Css 3compartmentss Human 95% 0.3438 mg/L 0.2228 mg/L 1.54308797127469 -DTXSID1026164 Css 3compartmentss Human 95% 3.332 mg/L 2.48 mg/L 1.34354838709677 -DTXSID1026241 Css 3compartmentss Human 95% 6.669 mg/L 1.297 mg/L 5.14186584425598 -DTXSID1026293 Css 3compartmentss Human 95% 136 mg/L 46.13 mg/L 2.94818989811403 -DTXSID1026457 Css 3compartmentss Human 95% 9.112 mg/L 5.86 mg/L 1.55494880546075 -DTXSID1026536 Css 3compartmentss Human 95% 8.613 mg/L 5.575 mg/L 1.54493273542601 -DTXSID1026619 Css 3compartmentss Human 95% 4.602 mg/L 2.8 mg/L 1.64357142857143 -DTXSID1026665 Css 3compartmentss Human 95% 5.579 mg/L 3.249 mg/L 1.71714373653432 -DTXSID1026667 Css 3compartmentss Human 95% 0.9525 mg/L 0.7217 mg/L 1.31980047110988 -DTXSID1026740 Css 3compartmentss Human 95% 0.2414 mg/L 0.1839 mg/L 1.31266992930941 -DTXSID1026792 Css 3compartmentss Human 95% 0.2371 mg/L 0.1705 mg/L 1.39061583577713 -DTXSID1026796 Css 3compartmentss Human 95% 0.03089 mg/L 0.02071 mg/L 1.49154997585707 -DTXSID1026879 Css 3compartmentss Human 95% 1.975 mg/L 1.398 mg/L 1.41273247496423 -DTXSID1026902 Css 3compartmentss Human 95% 0.132 mg/L 0.0009277 mg/L 142.28737738493 -DTXSID1026904 Css 3compartmentss Human 95% 0.06996 mg/L 0.04213 mg/L 1.66057441253264 -DTXSID1026908 Css 3compartmentss Human 95% 0.8493 mg/L 0.5408 mg/L 1.57045118343195 -DTXSID1026954 Css 3compartmentss Human 95% 0.3791 mg/L 0.2398 mg/L 1.58090075062552 -DTXSID1027007 Css 3compartmentss Human 95% 4.769 mg/L 2.177 mg/L 2.19062930638493 -DTXSID1027134 Css 3compartmentss Human 95% 16 mg/L 7.26 mg/L 2.20385674931129 -DTXSID1027188 Css 3compartmentss Human 95% 1.371 mg/L 0.9258 mg/L 1.48088139987038 -DTXSID1027219 Css 3compartmentss Human 95% 16.23 mg/L 9.891 mg/L 1.64088565362451 -DTXSID1027265 Css 3compartmentss Human 95% 3.154 mg/L 3.793 mg/L 0.831531769048247 -DTXSID1027344 Css 3compartmentss Human 95% 2.745 mg/L 3.051 mg/L 0.899705014749263 -DTXSID1027346 Css 3compartmentss Human 95% 0.7219 mg/L 0.2923 mg/L 2.46972288744441 -DTXSID1027390 Css 3compartmentss Human 95% 3.023 mg/L 1.555 mg/L 1.94405144694534 -DTXSID1027394 Css 3compartmentss Human 95% 23.64 mg/L 14.13 mg/L 1.67303609341826 -DTXSID1027396 Css 3compartmentss Human 95% 10010 mg/L 9281 mg/L 1.07854757030492 -DTXSID1027425 Css 3compartmentss Human 95% 32.49 mg/L 18.85 mg/L 1.7236074270557 -DTXSID1027427 Css 3compartmentss Human 95% 2.626 mg/L 1.755 mg/L 1.4962962962963 -DTXSID1027429 Css 3compartmentss Human 95% 37.12 mg/L 5.292 mg/L 7.01436130007559 -DTXSID1027479 Css 3compartmentss Human 95% 6.876 mg/L 2.368 mg/L 2.90371621621622 -DTXSID1027500 Css 3compartmentss Human 95% 3.386 mg/L 2.414 mg/L 1.4026512013256 -DTXSID1027502 Css 3compartmentss Human 95% 2.489 mg/L 1.506 mg/L 1.6527224435591 -DTXSID1027506 Css 3compartmentss Human 95% 17.22 mg/L 13.2 mg/L 1.30454545454545 -DTXSID1027550 Css 3compartmentss Human 95% 7.256 mg/L 4.643 mg/L 1.56278268360974 -DTXSID1027556 Css 3compartmentss Human 95% 8.338 mg/L 5.121 mg/L 1.6281976176528 -DTXSID1027558 Css 3compartmentss Human 95% 3.798 mg/L 2.308 mg/L 1.64558058925477 -DTXSID1027633 Css 3compartmentss Human 95% 5.2e-08 mg/L NA NA NA -DTXSID1027635 Css 3compartmentss Human 95% 44.04 mg/L 5.561 mg/L 7.91943894982917 -DTXSID1027639 Css 3compartmentss Human 95% 5.827 mg/L 3.718 mg/L 1.56724045185584 -DTXSID1027714 Css 3compartmentss Human 95% 4542 mg/L 9739 mg/L 0.466372317486395 -DTXSID1027716 Css 3compartmentss Human 95% 1.161e-06 mg/L NA NA NA -DTXSID1027764 Css 3compartmentss Human 95% 15 mg/L 9.808 mg/L 1.52936378466558 -DTXSID1027768 Css 3compartmentss Human 95% 8.257 mg/L 5.2 mg/L 1.58788461538462 -DTXSID1027841 Css 3compartmentss Human 95% 4.464 mg/L 2.663 mg/L 1.67630491926399 -DTXSID1027891 Css 3compartmentss Human 95% 32.01 mg/L 11.79 mg/L 2.71501272264631 -DTXSID1027899 Css 3compartmentss Human 95% 6.768 mg/L 3.833 mg/L 1.76571875815288 -DTXSID1027920 Css 3compartmentss Human 95% 0.2002 mg/L 0.0001394 mg/L 1436.15494978479 -DTXSID1027924 Css 3compartmentss Human 95% 0.006058 mg/L 0 mg/L Inf -DTXSID1027926 Css 3compartmentss Human 95% 0.6394 mg/L 1.3e-08 mg/L 49184615.3846154 -DTXSID1027970 Css 3compartmentss Human 95% 9.181 mg/L 10.46 mg/L 0.877724665391969 -DTXSID1027978 Css 3compartmentss Human 95% 0.8805 mg/L 0.3927 mg/L 2.24216959511077 -DTXSID1029120 Css 3compartmentss Human 95% 8.551 mg/L 4.979 mg/L 1.7174131351677 -DTXSID1029122 Css 3compartmentss Human 95% 1.752 mg/L 0.9248 mg/L 1.89446366782007 -DTXSID1029128 Css 3compartmentss Human 95% 5.161 mg/L 2.463 mg/L 2.09541209906618 -DTXSID1029170 Css 3compartmentss Human 95% 4.829 mg/L 3.702 mg/L 1.3044300378174 -DTXSID1029201 Css 3compartmentss Human 95% 8.757 mg/L 4.402 mg/L 1.9893230349841 -DTXSID1029203 Css 3compartmentss Human 95% 2.846 mg/L 1.887 mg/L 1.50821409644939 -DTXSID1029207 Css 3compartmentss Human 95% 2.12 mg/L 0.995 mg/L 2.13065326633166 -DTXSID1029251 Css 3compartmentss Human 95% 8.673 mg/L 5.235 mg/L 1.6567335243553 -DTXSID1029255 Css 3compartmentss Human 95% 6.958 mg/L 4.001 mg/L 1.73906523369158 -DTXSID1029629 Css 3compartmentss Human 95% 5.981 mg/L 3.877 mg/L 1.54268764508641 -DTXSID1029671 Css 3compartmentss Human 95% 7.415 mg/L 4.51 mg/L 1.64412416851441 -DTXSID1029677 Css 3compartmentss Human 95% 7.998 mg/L 5.776 mg/L 1.38469529085873 -DTXSID1029679 Css 3compartmentss Human 95% 167.1 mg/L 381.1 mg/L 0.4384675938074 -DTXSID1029889 Css 3compartmentss Human 95% 3.265 mg/L 1.655 mg/L 1.97280966767372 -DTXSID1030317 Css 3compartmentss Human 95% 4.063 mg/L 3.224 mg/L 1.26023573200993 -DTXSID1030319 Css 3compartmentss Human 95% 6.266 mg/L 3.714 mg/L 1.68712977921379 -DTXSID1030604 Css 3compartmentss Human 95% 7.295 mg/L 4.293 mg/L 1.69927789424645 -DTXSID1030606 Css 3compartmentss Human 95% 3.254 mg/L 1.938 mg/L 1.67905056759546 -DTXSID1031096 Css 3compartmentss Human 95% 0.00508 mg/L 0 mg/L Inf -DTXSID1031591 Css 3compartmentss Human 95% 7.75 mg/L 4.832 mg/L 1.60389072847682 -DTXSID1031626 Css 3compartmentss Human 95% 1.664 mg/L 1.224 mg/L 1.35947712418301 -DTXSID1032278 Css 3compartmentss Human 95% 0.06741 mg/L 0.0237 mg/L 2.84430379746835 -DTXSID1032303 Css 3compartmentss Human 95% 17.83 mg/L 8.665e-05 mg/L 205770.340450087 -DTXSID1032309 Css 3compartmentss Human 95% 22.4 mg/L 7.003 mg/L 3.19862915893189 -DTXSID1032355 Css 3compartmentss Human 95% 4.808 mg/L 4.213 mg/L 1.1412295276525 -DTXSID1032359 Css 3compartmentss Human 95% 43.94 mg/L 6.317 mg/L 6.95583346525249 -DTXSID1032482 Css 3compartmentss Human 95% 13.57 mg/L 4.284 mg/L 3.16760037348273 -DTXSID1032484 Css 3compartmentss Human 95% 0.1282 mg/L 5.978e-05 mg/L 2144.52994312479 -DTXSID1032488 Css 3compartmentss Human 95% 9.031 mg/L 1.477 mg/L 6.1144211238998 -DTXSID1032511 Css 3compartmentss Human 95% 1.102 mg/L 0.7327 mg/L 1.5040262044493 -DTXSID1032513 Css 3compartmentss Human 95% 0.7407 mg/L 0.4731 mg/L 1.56563094483196 -DTXSID1032519 Css 3compartmentss Human 95% 0.194 mg/L 0.08647 mg/L 2.2435526772291 -DTXSID1032569 Css 3compartmentss Human 95% 1.037 mg/L 0.6509 mg/L 1.59317867567983 -DTXSID1032640 Css 3compartmentss Human 95% 162.4 mg/L 15.9 mg/L 10.2138364779874 -DTXSID1032642 Css 3compartmentss Human 95% 7.705 mg/L 5.072 mg/L 1.51912460567823 -DTXSID1032646 Css 3compartmentss Human 95% 57.58 mg/L 0.04549 mg/L 1265.77269729611 -DTXSID1032648 Css 3compartmentss Human 95% 0.9488 mg/L 0.2785 mg/L 3.40682226211849 -DTXSID1032690 Css 3compartmentss Human 95% 14.81 mg/L 3.384 mg/L 4.37647754137116 -DTXSID1033161 Css 3compartmentss Human 95% 0.1128 mg/L 0.06967 mg/L 1.61906128893354 -DTXSID1033163 Css 3compartmentss Human 95% 57.48 mg/L 30.78 mg/L 1.86744639376218 -DTXSID1033371 Css 3compartmentss Human 95% 5.747 mg/L 3.88 mg/L 1.48118556701031 -DTXSID1033402 Css 3compartmentss Human 95% 119.9 mg/L 65.16 mg/L 1.84008594229589 -DTXSID1033539 Css 3compartmentss Human 95% 13.42 mg/L 9.122 mg/L 1.47116860337645 -DTXSID1033664 Css 3compartmentss Human 95% 8.808 mg/L 3.823 mg/L 2.30394977766152 -DTXSID1034181 Css 3compartmentss Human 95% 3.47 mg/L 0.6791 mg/L 5.10970402002651 -DTXSID1034187 Css 3compartmentss Human 95% 3646 mg/L 2204 mg/L 1.65426497277677 -DTXSID1034210 Css 3compartmentss Human 95% 28.99 mg/L 8.351 mg/L 3.47144054604239 -DTXSID1034212 Css 3compartmentss Human 95% 88.04 mg/L 3.504 mg/L 25.1255707762557 -DTXSID1034214 Css 3compartmentss Human 95% 0.1511 mg/L 0 mg/L Inf -DTXSID1034260 Css 3compartmentss Human 95% 3.593 mg/L 2.368 mg/L 1.51731418918919 -DTXSID1034266 Css 3compartmentss Human 95% 4.694 mg/L 3.307 mg/L 1.41941336558815 -DTXSID1034501 Css 3compartmentss Human 95% 2.766 mg/L 8.228e-06 mg/L 336169.178415168 -DTXSID1034503 Css 3compartmentss Human 95% 2.429 mg/L 0.7938 mg/L 3.05996472663139 -DTXSID1034634 Css 3compartmentss Human 95% 8.145 mg/L 3.344 mg/L 2.43570574162679 -DTXSID1034769 Css 3compartmentss Human 95% 9.575 mg/L 5.658 mg/L 1.69229409685401 -DTXSID1034844 Css 3compartmentss Human 95% 1.678 mg/L 1.175 mg/L 1.42808510638298 -DTXSID1034929 Css 3compartmentss Human 95% 3.19 mg/L 0.262 mg/L 12.175572519084 -DTXSID1034973 Css 3compartmentss Human 95% 413.7 mg/L 270.2 mg/L 1.53108808290155 -DTXSID1035286 Css 3compartmentss Human 95% 139.4 mg/L 0.005819 mg/L 23956.00618663 -DTXSID1035288 Css 3compartmentss Human 95% 2.53 mg/L 1.016 mg/L 2.49015748031496 -DTXSID1035783 Css 3compartmentss Human 95% 4.752 mg/L 0.02236 mg/L 212.522361359571 -DTXSID1036541 Css 3compartmentss Human 95% 4.551 mg/L 1.16 mg/L 3.92327586206897 -DTXSID1036545 Css 3compartmentss Human 95% 26.78 mg/L 9.002 mg/L 2.97489446789602 -DTXSID1037197 Css 3compartmentss Human 95% 0.1198 mg/L 0.07299 mg/L 1.64132072886697 -DTXSID1037224 Css 3compartmentss Human 95% 0.2914 mg/L 0.2679 mg/L 1.08771929824561 -DTXSID1037272 Css 3compartmentss Human 95% 0.005082 mg/L 0.001788 mg/L 2.84228187919463 -DTXSID1037303 Css 3compartmentss Human 95% 3840 mg/L 2240 mg/L 1.71428571428571 -DTXSID1037511 Css 3compartmentss Human 95% 0.5993 mg/L 0.3491 mg/L 1.71670008593526 -DTXSID1037515 Css 3compartmentss Human 95% 0.7395 mg/L 0.3638 mg/L 2.03271028037383 -DTXSID1037565 Css 3compartmentss Human 95% 3.276 mg/L 1.369 mg/L 2.39298758217677 -DTXSID1037567 Css 3compartmentss Human 95% 2.804 mg/L 1.555 mg/L 1.8032154340836 -DTXSID1037696 Css 3compartmentss Human 95% 0.1319 mg/L 0.08739 mg/L 1.50932600984094 -DTXSID1037806 Css 3compartmentss Human 95% 2.78 mg/L 1.601 mg/L 1.73641474078701 -DTXSID1038321 Css 3compartmentss Human 95% 398.2 mg/L 234 mg/L 1.7017094017094 -DTXSID1038666 Css 3compartmentss Human 95% 5.17 mg/L 2.723 mg/L 1.8986412045538 -DTXSID1038743 Css 3compartmentss Human 95% 4.135 mg/L 2.559 mg/L 1.61586557248925 -DTXSID1038822 Css 3compartmentss Human 95% 1.183 mg/L 0.1736 mg/L 6.81451612903226 -DTXSID1038824 Css 3compartmentss Human 95% 5.296 mg/L 3.325 mg/L 1.59278195488722 -DTXSID1038876 Css 3compartmentss Human 95% 2.203 mg/L 0.3395 mg/L 6.48895434462445 -DTXSID1039719 Css 3compartmentss Human 95% 18.35 mg/L 27.08 mg/L 0.677621861152142 -DTXSID1040114 Css 3compartmentss Human 95% 1.829 mg/L 1.263 mg/L 1.44813935075218 -DTXSID1040164 Css 3compartmentss Human 95% 5.619 mg/L 3.275 mg/L 1.71572519083969 -DTXSID1040245 Css 3compartmentss Human 95% 8.647 mg/L 5.53 mg/L 1.56365280289331 -DTXSID1040295 Css 3compartmentss Human 95% 0.316 mg/L 0.2266 mg/L 1.39452780229479 -DTXSID1040320 Css 3compartmentss Human 95% 1.497 mg/L 0.406 mg/L 3.6871921182266 -DTXSID1040324 Css 3compartmentss Human 95% 0.3639 mg/L 0.1995 mg/L 1.82406015037594 -DTXSID1040326 Css 3compartmentss Human 95% 5.842 mg/L 3.741 mg/L 1.56161454156643 -DTXSID1040372 Css 3compartmentss Human 95% 70.14 mg/L 42.61 mg/L 1.64609246655715 -DTXSID1040459 Css 3compartmentss Human 95% 4.593 mg/L 2.385 mg/L 1.92578616352201 -DTXSID1040611 Css 3compartmentss Human 95% 0.02046 mg/L 0 mg/L Inf -DTXSID1040617 Css 3compartmentss Human 95% 0.9187 mg/L 0.592 mg/L 1.55185810810811 -DTXSID1040619 Css 3compartmentss Human 95% 195.3 mg/L 5.393 mg/L 36.2136102354905 -DTXSID1040661 Css 3compartmentss Human 95% 150.8 mg/L 87.72 mg/L 1.71910624715002 -DTXSID1040667 Css 3compartmentss Human 95% 0.5225 mg/L 0.3075 mg/L 1.69918699186992 -DTXSID1040740 Css 3compartmentss Human 95% 2.429 mg/L 0.9953 mg/L 2.44047020998694 -DTXSID1040742 Css 3compartmentss Human 95% 1.573 mg/L 0.9666 mg/L 1.62735361059383 -DTXSID1040792 Css 3compartmentss Human 95% 3.082 mg/L 2.192 mg/L 1.40602189781022 -DTXSID1040794 Css 3compartmentss Human 95% 6.761 mg/L 4.634 mg/L 1.45899870522227 -DTXSID1041132 Css 3compartmentss Human 95% 6.27 mg/L 3.066 mg/L 2.04500978473581 -DTXSID1041188 Css 3compartmentss Human 95% 3.173 mg/L 2.841 mg/L 1.11686026047166 -DTXSID1041217 Css 3compartmentss Human 95% 11.81 mg/L 8.742 mg/L 1.35094943948753 -DTXSID1041261 Css 3compartmentss Human 95% 1.161 mg/L 0.7096 mg/L 1.63613303269448 -DTXSID1041263 Css 3compartmentss Human 95% 2.726 mg/L 2.291 mg/L 1.18987341772152 -DTXSID1041265 Css 3compartmentss Human 95% 37.41 mg/L 0.0006484 mg/L 57695.8667489204 -DTXSID1041267 Css 3compartmentss Human 95% 4.885 mg/L 2.43 mg/L 2.01028806584362 -DTXSID1041346 Css 3compartmentss Human 95% 2.513 mg/L 1.166 mg/L 2.15523156089194 -DTXSID1041421 Css 3compartmentss Human 95% 0.394 mg/L 0.237 mg/L 1.66244725738397 -DTXSID1041423 Css 3compartmentss Human 95% 2.405 mg/L 2.328 mg/L 1.03307560137457 -DTXSID1041502 Css 3compartmentss Human 95% 4.486 mg/L 0.1467 mg/L 30.5794137695978 -DTXSID1041506 Css 3compartmentss Human 95% 3.684 mg/L 1.444 mg/L 2.55124653739612 -DTXSID1041550 Css 3compartmentss Human 95% 5.096 mg/L 2.796 mg/L 1.82260371959943 -DTXSID1041639 Css 3compartmentss Human 95% 9.561 mg/L 5.611 mg/L 1.70397433612547 -DTXSID1041681 Css 3compartmentss Human 95% 503.9 mg/L 288.3 mg/L 1.74783211932015 -DTXSID1041683 Css 3compartmentss Human 95% 7.69 mg/L 0.1137 mg/L 67.6341248900616 -DTXSID1041689 Css 3compartmentss Human 95% 49.26 mg/L 11.9 mg/L 4.13949579831933 -DTXSID1041847 Css 3compartmentss Human 95% 3.206 mg/L 0.04996 mg/L 64.1713370696557 -DTXSID1041897 Css 3compartmentss Human 95% 0.229 mg/L 0.1888 mg/L 1.21292372881356 -DTXSID1041920 Css 3compartmentss Human 95% 4.287 mg/L 3.208 mg/L 1.33634663341646 -DTXSID1041970 Css 3compartmentss Human 95% 5.271 mg/L 5.511 mg/L 0.956450734893849 -DTXSID1041978 Css 3compartmentss Human 95% 14.67 mg/L 0.02377 mg/L 617.164493058477 -DTXSID1042077 Css 3compartmentss Human 95% 14.99 mg/L 10.15 mg/L 1.47684729064039 -DTXSID1042154 Css 3compartmentss Human 95% 10.85 mg/L 5.887 mg/L 1.84304399524376 -DTXSID1042281 Css 3compartmentss Human 95% 10.09 mg/L 6.239 mg/L 1.6172463535823 -DTXSID1042285 Css 3compartmentss Human 95% 0.2524 mg/L 0.1672 mg/L 1.50956937799043 -DTXSID1042360 Css 3compartmentss Human 95% 1.621 mg/L 1.113 mg/L 1.45642407906559 -DTXSID1042364 Css 3compartmentss Human 95% 264.1 mg/L 153.7 mg/L 1.71828236824984 -DTXSID1042441 Css 3compartmentss Human 95% 3.5 mg/L 1.03 mg/L 3.39805825242718 -DTXSID1042443 Css 3compartmentss Human 95% 1.721 mg/L 0.9558 mg/L 1.80058589663109 -DTXSID1042445 Css 3compartmentss Human 95% 1.008 mg/L 0.607 mg/L 1.66062602965404 -DTXSID1042499 Css 3compartmentss Human 95% 3.856 mg/L 8.6e-08 mg/L 44837209.3023256 -DTXSID1042570 Css 3compartmentss Human 95% 2.126 mg/L 0.01778 mg/L 119.572553430821 -DTXSID1042574 Css 3compartmentss Human 95% 1.578 mg/L 1.083 mg/L 1.45706371191136 -DTXSID1043835 Css 3compartmentss Human 95% 2.385 mg/L 1.449 mg/L 1.64596273291925 -DTXSID1043839 Css 3compartmentss Human 95% 3.764 mg/L 1.346 mg/L 2.7964338781575 -DTXSID1043881 Css 3compartmentss Human 95% 2.294 mg/L 0.1476 mg/L 15.5420054200542 -DTXSID1043910 Css 3compartmentss Human 95% 0.5038 mg/L 0.3616 mg/L 1.39325221238938 -DTXSID1044196 Css 3compartmentss Human 95% 7.773 mg/L 3.469 mg/L 2.24070337272989 -DTXSID1044198 Css 3compartmentss Human 95% 9.34 mg/L 5.893 mg/L 1.58493127439335 -DTXSID1044221 Css 3compartmentss Human 95% 0.04493 mg/L 0.02283 mg/L 1.96802452912834 -DTXSID1044223 Css 3compartmentss Human 95% 25.45 mg/L 6.399 mg/L 3.97718393498984 -DTXSID1044227 Css 3compartmentss Human 95% 0.6964 mg/L 0.5311 mg/L 1.31124082093768 -DTXSID1044356 Css 3compartmentss Human 95% 0.3348 mg/L 0.2145 mg/L 1.56083916083916 -DTXSID1044431 Css 3compartmentss Human 95% 5.252 mg/L 3.709 mg/L 1.41601509840927 -DTXSID1044433 Css 3compartmentss Human 95% 7.884 mg/L 4.948 mg/L 1.59337105901374 -DTXSID1044435 Css 3compartmentss Human 95% 0.095 mg/L 0.06266 mg/L 1.51611873603575 -DTXSID1044437 Css 3compartmentss Human 95% 7.765 mg/L 4.801 mg/L 1.6173713809623 -DTXSID1044439 Css 3compartmentss Human 95% 6.562 mg/L 3.975 mg/L 1.65081761006289 -DTXSID1044481 Css 3compartmentss Human 95% 1.305 mg/L 0.8628 mg/L 1.5125173852573 -DTXSID1044485 Css 3compartmentss Human 95% 7.133 mg/L 4.351 mg/L 1.63939324293266 -DTXSID1044487 Css 3compartmentss Human 95% 0.01001 mg/L 6.158e-05 mg/L 162.552776875609 -DTXSID1044489 Css 3compartmentss Human 95% 6.658 mg/L 4.047 mg/L 1.64516926118112 -DTXSID1044514 Css 3compartmentss Human 95% 2.284 mg/L 0.4437 mg/L 5.14762226729772 -DTXSID1044560 Css 3compartmentss Human 95% 4.767 mg/L 3.076 mg/L 1.54973992197659 -DTXSID1044564 Css 3compartmentss Human 95% 92.72 mg/L 54.7 mg/L 1.69506398537477 -DTXSID1044568 Css 3compartmentss Human 95% 3.032 mg/L 2.896 mg/L 1.04696132596685 -DTXSID1044645 Css 3compartmentss Human 95% 0.7532 mg/L 0.5166 mg/L 1.4579945799458 -DTXSID1044691 Css 3compartmentss Human 95% 19.06 mg/L 0.2658 mg/L 71.7080511662904 -DTXSID1044693 Css 3compartmentss Human 95% 16.23 mg/L 9.891 mg/L 1.64088565362451 -DTXSID1044697 Css 3compartmentss Human 95% 8.463 mg/L 8.737 mg/L 0.968639120979741 -DTXSID1044720 Css 3compartmentss Human 95% 2.132 mg/L 1.414 mg/L 1.50777934936351 -DTXSID1044722 Css 3compartmentss Human 95% 1.334 mg/L 0.8186 mg/L 1.6296115318837 -DTXSID1044724 Css 3compartmentss Human 95% 8.126 mg/L 5.963 mg/L 1.3627368774107 -DTXSID1044770 Css 3compartmentss Human 95% 0.1252 mg/L 0.08337 mg/L 1.50173923473672 -DTXSID1044774 Css 3compartmentss Human 95% 4.014 mg/L 2.55 mg/L 1.57411764705882 -DTXSID1044776 Css 3compartmentss Human 95% 4.759 mg/L 2.126 mg/L 2.23847601128881 -DTXSID1044801 Css 3compartmentss Human 95% 4.363 mg/L 2.634 mg/L 1.65641609719058 -DTXSID1044805 Css 3compartmentss Human 95% 0.5069 mg/L 0.3355 mg/L 1.51087928464978 -DTXSID1044807 Css 3compartmentss Human 95% 0.1013 mg/L 0.06274 mg/L 1.61459993624482 -DTXSID1044809 Css 3compartmentss Human 95% 1.107 mg/L 0.9865 mg/L 1.12214901165737 -DTXSID1044851 Css 3compartmentss Human 95% 9.288 mg/L 6.117 mg/L 1.5183913683178 -DTXSID1044853 Css 3compartmentss Human 95% 4.81 mg/L 2.784 mg/L 1.72772988505747 -DTXSID1044859 Css 3compartmentss Human 95% 58.08 mg/L 34.26 mg/L 1.69527145359019 -DTXSID1044930 Css 3compartmentss Human 95% 2.332 mg/L 1.356 mg/L 1.71976401179941 -DTXSID1044932 Css 3compartmentss Human 95% 7.255 mg/L 4.1 mg/L 1.76951219512195 -DTXSID1044934 Css 3compartmentss Human 95% 1.593 mg/L 1.124 mg/L 1.41725978647687 -DTXSID1044938 Css 3compartmentss Human 95% 3.25 mg/L 2.469 mg/L 1.31632239773188 -DTXSID1044980 Css 3compartmentss Human 95% 0.7673 mg/L 0.559 mg/L 1.37262969588551 -DTXSID1044982 Css 3compartmentss Human 95% 3.371 mg/L 1.793 mg/L 1.88008923591746 -DTXSID1044986 Css 3compartmentss Human 95% 6.555 mg/L 4.494 mg/L 1.45861148197597 -DTXSID1045033 Css 3compartmentss Human 95% 1397 mg/L 794.3 mg/L 1.75878131688279 -DTXSID1045081 Css 3compartmentss Human 95% 1.631 mg/L 1.017 mg/L 1.60373647984267 -DTXSID1045083 Css 3compartmentss Human 95% 5.545 mg/L 1.04 mg/L 5.33173076923077 -DTXSID1045085 Css 3compartmentss Human 95% 5.683 mg/L 0.1581 mg/L 35.9456040480708 -DTXSID1045089 Css 3compartmentss Human 95% 17.91 mg/L 10.73 mg/L 1.66915191053122 -DTXSID1045110 Css 3compartmentss Human 95% 43.11 mg/L 0.4828 mg/L 89.2916321458161 -DTXSID1045112 Css 3compartmentss Human 95% 0.1597 mg/L 0.1112 mg/L 1.43615107913669 -DTXSID1045114 Css 3compartmentss Human 95% 10.16 mg/L 5.548 mg/L 1.83129055515501 -DTXSID1045116 Css 3compartmentss Human 95% 3.354 mg/L 1.874 mg/L 1.7897545357524 -DTXSID1045118 Css 3compartmentss Human 95% 1622 mg/L 533.3 mg/L 3.04144009000563 -DTXSID1045160 Css 3compartmentss Human 95% 1.286 mg/L 0.8006 mg/L 1.60629527854109 -DTXSID1045162 Css 3compartmentss Human 95% 0.4396 mg/L 0.2686 mg/L 1.63663440059568 -DTXSID1045164 Css 3compartmentss Human 95% 56.47 mg/L 31.74 mg/L 1.77914303717706 -DTXSID1045166 Css 3compartmentss Human 95% 1.587 mg/L 1.117 mg/L 1.42076991942704 -DTXSID1045168 Css 3compartmentss Human 95% 25.85 mg/L 17.37 mg/L 1.48819804260219 -DTXSID1045245 Css 3compartmentss Human 95% 3.649 mg/L 3.455 mg/L 1.0561505065123 -DTXSID1045291 Css 3compartmentss Human 95% 128.7 mg/L 65.76 mg/L 1.95711678832117 -DTXSID1045293 Css 3compartmentss Human 95% 0.8736 mg/L 0.3002 mg/L 2.91005996002665 -DTXSID1045297 Css 3compartmentss Human 95% 1.625 mg/L 0.004326 mg/L 375.635691169672 -DTXSID1045320 Css 3compartmentss Human 95% 2.085 mg/L 1.481 mg/L 1.40783254557731 -DTXSID1045322 Css 3compartmentss Human 95% 0.177 mg/L 0.1336 mg/L 1.3248502994012 -DTXSID1045324 Css 3compartmentss Human 95% 1.442 mg/L 0.6067 mg/L 2.37679248392945 -DTXSID1045326 Css 3compartmentss Human 95% 1.123 mg/L 5e-08 mg/L 22460000 -DTXSID1045328 Css 3compartmentss Human 95% 0.4802 mg/L 0.1603 mg/L 2.99563318777293 -DTXSID1045370 Css 3compartmentss Human 95% 0.4103 mg/L 0.2505 mg/L 1.63792415169661 -DTXSID1045372 Css 3compartmentss Human 95% 1.268 mg/L 0.3165 mg/L 4.00631911532385 -DTXSID1045376 Css 3compartmentss Human 95% 2.464 mg/L 1.69 mg/L 1.45798816568047 -DTXSID1045405 Css 3compartmentss Human 95% 7.35 mg/L 4.914 mg/L 1.4957264957265 -DTXSID1045453 Css 3compartmentss Human 95% 0.4022 mg/L 0.3398 mg/L 1.18363743378458 -DTXSID1045459 Css 3compartmentss Human 95% 0.2203 mg/L 0.1274 mg/L 1.72919937205651 -DTXSID1045530 Css 3compartmentss Human 95% 1.126 mg/L 0.7307 mg/L 1.54098809360887 -DTXSID1045534 Css 3compartmentss Human 95% 0.5706 mg/L 0.3282 mg/L 1.73857404021938 -DTXSID1045536 Css 3compartmentss Human 95% 11.5 mg/L 7.213 mg/L 1.5943435463746 -DTXSID1045538 Css 3compartmentss Human 95% 0.3637 mg/L 0.2236 mg/L 1.62656529516995 -DTXSID1045580 Css 3compartmentss Human 95% 0.1752 mg/L 0.1499 mg/L 1.16877918612408 -DTXSID1045582 Css 3compartmentss Human 95% 50.83 mg/L 32.49 mg/L 1.56448137888581 -DTXSID1045584 Css 3compartmentss Human 95% 957.4 mg/L 549.6 mg/L 1.7419941775837 -DTXSID1045586 Css 3compartmentss Human 95% 22.77 mg/L 0.1674 mg/L 136.021505376344 -DTXSID1045588 Css 3compartmentss Human 95% 0.5444 mg/L 0.4841 mg/L 1.12456104110721 -DTXSID1045611 Css 3compartmentss Human 95% 6.053 mg/L 3.243 mg/L 1.86648165279063 -DTXSID1045615 Css 3compartmentss Human 95% 1.046 mg/L 0.6983 mg/L 1.49792352856938 -DTXSID1045619 Css 3compartmentss Human 95% 0.746 mg/L 0.4515 mg/L 1.65227021040975 -DTXSID1045661 Css 3compartmentss Human 95% 1.232 mg/L 0.4127 mg/L 2.98521928761812 -DTXSID1045663 Css 3compartmentss Human 95% 0.2477 mg/L 0.04266 mg/L 5.80637599624941 -DTXSID1045665 Css 3compartmentss Human 95% 111.9 mg/L 52.16 mg/L 2.14532208588957 -DTXSID1045669 Css 3compartmentss Human 95% 5072 mg/L 9739 mg/L 0.520792689187802 -DTXSID1045740 Css 3compartmentss Human 95% 5.834 mg/L 3.892 mg/L 1.49897225077081 -DTXSID1045742 Css 3compartmentss Human 95% 434.1 mg/L 248.5 mg/L 1.74688128772636 -DTXSID1045744 Css 3compartmentss Human 95% 6.172 mg/L 1.523 mg/L 4.05252790544977 -DTXSID1045746 Css 3compartmentss Human 95% 26.55 mg/L 13.38 mg/L 1.98430493273543 -DTXSID1045748 Css 3compartmentss Human 95% 2.677 mg/L 1.856 mg/L 1.44234913793103 -DTXSID1045790 Css 3compartmentss Human 95% 1.697 mg/L 1.568 mg/L 1.08227040816327 -DTXSID1045792 Css 3compartmentss Human 95% 5.872 mg/L 2.238 mg/L 2.62377122430742 -DTXSID1045794 Css 3compartmentss Human 95% 1.337 mg/L 0.9197 mg/L 1.45373491355877 -DTXSID1045798 Css 3compartmentss Human 95% 0.9974 mg/L 0.3051 mg/L 3.26909210095051 -DTXSID1045871 Css 3compartmentss Human 95% 639.4 mg/L 270.9 mg/L 2.36028054632706 -DTXSID1045873 Css 3compartmentss Human 95% 8.753 mg/L 5.267 mg/L 1.66185684450351 -DTXSID1045877 Css 3compartmentss Human 95% 5.584 mg/L 3.628 mg/L 1.53914002205072 -DTXSID1045879 Css 3compartmentss Human 95% 4.186 mg/L 2.441 mg/L 1.71487095452683 -DTXSID1045900 Css 3compartmentss Human 95% 12.2 mg/L 10.05 mg/L 1.21393034825871 -DTXSID1045902 Css 3compartmentss Human 95% 7.731 mg/L 3.597 mg/L 2.14929107589658 -DTXSID1045904 Css 3compartmentss Human 95% 0.3902 mg/L 0.2004 mg/L 1.94710578842315 -DTXSID1045906 Css 3compartmentss Human 95% 1.818 mg/L 1.102 mg/L 1.6497277676951 -DTXSID1045950 Css 3compartmentss Human 95% 2.115 mg/L 1.336 mg/L 1.58308383233533 -DTXSID1045952 Css 3compartmentss Human 95% 4.038 mg/L 2.435 mg/L 1.65831622176591 -DTXSID1045954 Css 3compartmentss Human 95% 0.3652 mg/L 0.2441 mg/L 1.49610815239656 -DTXSID1045956 Css 3compartmentss Human 95% 93.06 mg/L 52.44 mg/L 1.7745995423341 -DTXSID1045958 Css 3compartmentss Human 95% 1.633 mg/L 0.9701 mg/L 1.68333161529739 -DTXSID1046003 Css 3compartmentss Human 95% 4.482 mg/L 2.727 mg/L 1.64356435643564 -DTXSID1046007 Css 3compartmentss Human 95% 0.2905 mg/L 0.2989 mg/L 0.971896955503513 -DTXSID1046009 Css 3compartmentss Human 95% 0.01822 mg/L 0.009536 mg/L 1.91065436241611 -DTXSID1046051 Css 3compartmentss Human 95% 5.575 mg/L 3.628 mg/L 1.53665931642778 -DTXSID1046055 Css 3compartmentss Human 95% 0.641 mg/L 0.1206 mg/L 5.3150912106136 -DTXSID1046059 Css 3compartmentss Human 95% 5.34 mg/L 2.993 mg/L 1.78416304710992 -DTXSID1046130 Css 3compartmentss Human 95% 0.5079 mg/L 0.3083 mg/L 1.64742134284788 -DTXSID1046132 Css 3compartmentss Human 95% 7.682 mg/L 4.767 mg/L 1.61149569960143 -DTXSID1046134 Css 3compartmentss Human 95% 112.2 mg/L 28.17 mg/L 3.98296059637913 -DTXSID1046136 Css 3compartmentss Human 95% 29.68 mg/L 17.49 mg/L 1.6969696969697 -DTXSID1046138 Css 3compartmentss Human 95% 68.63 mg/L 37.58 mg/L 1.82623736029803 -DTXSID1046180 Css 3compartmentss Human 95% 2.821 mg/L 0.5961 mg/L 4.73242744505955 -DTXSID1046182 Css 3compartmentss Human 95% 0.2744 mg/L 0.1774 mg/L 1.5467869222097 -DTXSID1046186 Css 3compartmentss Human 95% 0.9063 mg/L 0.7018 mg/L 1.29139355941864 -DTXSID1046188 Css 3compartmentss Human 95% 0.3848 mg/L 0.2218 mg/L 1.73489630297565 -DTXSID1046211 Css 3compartmentss Human 95% 146.7 mg/L 80.22 mg/L 1.82872101720269 -DTXSID1046213 Css 3compartmentss Human 95% 0.1159 mg/L 0.03322 mg/L 3.48886213124624 -DTXSID1046215 Css 3compartmentss Human 95% 4.532 mg/L 2.683 mg/L 1.68915393216549 -DTXSID1046217 Css 3compartmentss Human 95% 17.96 mg/L 2.237 mg/L 8.02860974519446 -DTXSID1046261 Css 3compartmentss Human 95% 5.731 mg/L 3.628 mg/L 1.57965821389195 -DTXSID1046263 Css 3compartmentss Human 95% 30.65 mg/L 9739 mg/L 0.00314714036348701 -DTXSID1046265 Css 3compartmentss Human 95% 434.5 mg/L 249.6 mg/L 1.74078525641026 -DTXSID1046267 Css 3compartmentss Human 95% 2.973 mg/L 1.75 mg/L 1.69885714285714 -DTXSID1046269 Css 3compartmentss Human 95% 0.3495 mg/L 0.2613 mg/L 1.33754305396096 -DTXSID1046342 Css 3compartmentss Human 95% 36.94 mg/L 8.474 mg/L 4.35921642671702 -DTXSID1046344 Css 3compartmentss Human 95% 1823 mg/L 1042 mg/L 1.74952015355086 -DTXSID1046346 Css 3compartmentss Human 95% 5.532 mg/L 3.307 mg/L 1.67281524039915 -DTXSID1046348 Css 3compartmentss Human 95% 5.067 mg/L 3.341 mg/L 1.51661179287638 -DTXSID1046390 Css 3compartmentss Human 95% 2.885 mg/L 1.613 mg/L 1.78859268443893 -DTXSID1046392 Css 3compartmentss Human 95% 2.877 mg/L 1.879 mg/L 1.53113358169239 -DTXSID1046394 Css 3compartmentss Human 95% 43.21 mg/L 23.97 mg/L 1.80267000417188 -DTXSID1046396 Css 3compartmentss Human 95% 0.002407 mg/L 0 mg/L Inf -DTXSID1046398 Css 3compartmentss Human 95% 1.195 mg/L 0.7266 mg/L 1.64464629782549 -DTXSID1046421 Css 3compartmentss Human 95% 7.963 mg/L 4.901 mg/L 1.62477045500918 -DTXSID1046423 Css 3compartmentss Human 95% 6.587 mg/L 3.434 mg/L 1.91817122888759 -DTXSID1046425 Css 3compartmentss Human 95% 0.8989 mg/L 0.5052 mg/L 1.77929532858274 -DTXSID1046427 Css 3compartmentss Human 95% 1.848 mg/L 0.1509 mg/L 12.2465208747515 -DTXSID1046429 Css 3compartmentss Human 95% 0.9087 mg/L 0.01468 mg/L 61.9005449591281 -DTXSID1046471 Css 3compartmentss Human 95% 0.5681 mg/L 0.3411 mg/L 1.66549399003225 -DTXSID1046475 Css 3compartmentss Human 95% 0.09932 mg/L 0.06287 mg/L 1.57976777477334 -DTXSID1046477 Css 3compartmentss Human 95% 19.59 mg/L 10.77 mg/L 1.81894150417827 -DTXSID1046479 Css 3compartmentss Human 95% 16.28 mg/L 9.123 mg/L 1.78450071248493 -DTXSID1046500 Css 3compartmentss Human 95% 20.03 mg/L 7.955 mg/L 2.51791326209931 -DTXSID1046502 Css 3compartmentss Human 95% 1.82 mg/L 1.344 mg/L 1.35416666666667 -DTXSID1046504 Css 3compartmentss Human 95% 1.268 mg/L 0.518 mg/L 2.44787644787645 -DTXSID1046506 Css 3compartmentss Human 95% 2.198 mg/L 1.316 mg/L 1.67021276595745 -DTXSID1046508 Css 3compartmentss Human 95% 2.099 mg/L 0.6121 mg/L 3.42917823884986 -DTXSID1046550 Css 3compartmentss Human 95% 4.005 mg/L 2.093 mg/L 1.91352126134735 -DTXSID1046552 Css 3compartmentss Human 95% 0.03024 mg/L 0.01865 mg/L 1.62144772117962 -DTXSID1046556 Css 3compartmentss Human 95% 6.047 mg/L 0.1322 mg/L 45.7413010590015 -DTXSID1046558 Css 3compartmentss Human 95% 2.925 mg/L 2.229 mg/L 1.31224764468371 -DTXSID1046631 Css 3compartmentss Human 95% 1.891 mg/L 0.5576 mg/L 3.39131994261119 -DTXSID1046633 Css 3compartmentss Human 95% 0.8985 mg/L 0.7357 mg/L 1.22128585021068 -DTXSID1046637 Css 3compartmentss Human 95% 63.17 mg/L 31.95 mg/L 1.97715179968701 -DTXSID1046639 Css 3compartmentss Human 95% 1.361 mg/L 1.016 mg/L 1.33956692913386 -DTXSID1046681 Css 3compartmentss Human 95% 5.992 mg/L 3.387 mg/L 1.76911721287275 -DTXSID1046683 Css 3compartmentss Human 95% 245 mg/L 607.4 mg/L 0.403358577543629 -DTXSID1046685 Css 3compartmentss Human 95% 92.69 mg/L 50.02 mg/L 1.8530587764894 -DTXSID1046687 Css 3compartmentss Human 95% 0.8925 mg/L 0.5208 mg/L 1.71370967741935 -DTXSID1046689 Css 3compartmentss Human 95% 0.2458 mg/L 0.1438 mg/L 1.70931849791377 -DTXSID1046710 Css 3compartmentss Human 95% 0.2172 mg/L 0.1683 mg/L 1.29055258467023 -DTXSID1046712 Css 3compartmentss Human 95% 8.998 mg/L 5.463 mg/L 1.64708035877723 -DTXSID1046714 Css 3compartmentss Human 95% 0.9933 mg/L 0.5806 mg/L 1.71081639683086 -DTXSID1046716 Css 3compartmentss Human 95% 173.7 mg/L 93.06 mg/L 1.86653771760155 -DTXSID1046760 Css 3compartmentss Human 95% 0.4013 mg/L 0.2778 mg/L 1.44456443484521 -DTXSID1046764 Css 3compartmentss Human 95% 0.696 mg/L 0.4904 mg/L 1.41924959216966 -DTXSID1046766 Css 3compartmentss Human 95% 2.044 mg/L 1.643 mg/L 1.24406573341449 -DTXSID1046768 Css 3compartmentss Human 95% 679.8 mg/L 364.1 mg/L 1.86706948640483 -DTXSID1046841 Css 3compartmentss Human 95% 2.161 mg/L 0.9986 mg/L 2.1640296414981 -DTXSID1046843 Css 3compartmentss Human 95% 30.87 mg/L 0.4674 mg/L 66.0462130937099 -DTXSID1046845 Css 3compartmentss Human 95% 3.762 mg/L 2.711 mg/L 1.38767982294356 -DTXSID1046847 Css 3compartmentss Human 95% 4.289 mg/L 1.22 mg/L 3.5155737704918 -DTXSID1046849 Css 3compartmentss Human 95% 0.3478 mg/L 0.2188 mg/L 1.58957952468007 -DTXSID1046891 Css 3compartmentss Human 95% 9.921 mg/L 6.145 mg/L 1.61448331977217 -DTXSID1046895 Css 3compartmentss Human 95% 5.552 mg/L 3.733 mg/L 1.48727564961157 -DTXSID1046926 Css 3compartmentss Human 95% 0.03312 mg/L 0.01768 mg/L 1.87330316742081 -DTXSID1046970 Css 3compartmentss Human 95% 3.422 mg/L 0.9172 mg/L 3.73092019188836 -DTXSID1046974 Css 3compartmentss Human 95% 0.6508 mg/L 0.4737 mg/L 1.37386531560059 -DTXSID1046976 Css 3compartmentss Human 95% 8.413 mg/L 4.951 mg/L 1.69925267622703 -DTXSID1046978 Css 3compartmentss Human 95% 0.5899 mg/L 0.3162 mg/L 1.86559139784946 -DTXSID1047027 Css 3compartmentss Human 95% 6.583e-05 mg/L 0 mg/L Inf -DTXSID1047029 Css 3compartmentss Human 95% 256.4 mg/L 9739 mg/L 0.0263271383098881 -DTXSID1047071 Css 3compartmentss Human 95% 1.688 mg/L 1.242 mg/L 1.35909822866345 -DTXSID1047075 Css 3compartmentss Human 95% 1.662 mg/L 1.092 mg/L 1.52197802197802 -DTXSID1047102 Css 3compartmentss Human 95% 0.1787 mg/L 1.65e-05 mg/L 10830.303030303 -DTXSID1047106 Css 3compartmentss Human 95% 14.95 mg/L 9.028 mg/L 1.65595923792645 -DTXSID1047150 Css 3compartmentss Human 95% 39.55 mg/L 21.24 mg/L 1.8620527306968 -DTXSID1047158 Css 3compartmentss Human 95% 9.463 mg/L 8.043 mg/L 1.17655103816984 -DTXSID1047239 Css 3compartmentss Human 95% 4.442 mg/L 0.2546 mg/L 17.4469756480754 -DTXSID1047281 Css 3compartmentss Human 95% 5.039 mg/L 2.703 mg/L 1.86422493525712 -DTXSID1047283 Css 3compartmentss Human 95% 3.071 mg/L 0.2628 mg/L 11.6856925418569 -DTXSID1047285 Css 3compartmentss Human 95% 0.742 mg/L 0.5814 mg/L 1.27622979016168 -DTXSID1047287 Css 3compartmentss Human 95% 44.34 mg/L 21.22 mg/L 2.08953817153629 -DTXSID1047289 Css 3compartmentss Human 95% 1.656 mg/L 0.6829 mg/L 2.42495240884463 -DTXSID1047310 Css 3compartmentss Human 95% 96.74 mg/L 0.02716 mg/L 3561.85567010309 -DTXSID1047312 Css 3compartmentss Human 95% 2.934 mg/L 1.504 mg/L 1.95079787234043 -DTXSID1047316 Css 3compartmentss Human 95% 3.743 mg/L 0.2734 mg/L 13.6905632772495 -DTXSID1047318 Css 3compartmentss Human 95% 60.74 mg/L 42.84 mg/L 1.41783380018674 -DTXSID1047360 Css 3compartmentss Human 95% 0.855 mg/L 0.2028 mg/L 4.21597633136095 -DTXSID1047362 Css 3compartmentss Human 95% 3.133 mg/L 1.033 mg/L 3.03291384317522 -DTXSID1047364 Css 3compartmentss Human 95% 2.98 mg/L 0.01327 mg/L 224.566691785983 -DTXSID1047366 Css 3compartmentss Human 95% 21.8 mg/L 0.3463 mg/L 62.951198382905 -DTXSID1047368 Css 3compartmentss Human 95% 0.3037 mg/L 0.2618 mg/L 1.16004583651643 -DTXSID1047443 Css 3compartmentss Human 95% 0.2681 mg/L 0.1839 mg/L 1.45785753126699 -DTXSID1047447 Css 3compartmentss Human 95% 0.08742 mg/L 0.0546 mg/L 1.6010989010989 -DTXSID1047491 Css 3compartmentss Human 95% 1.385 mg/L 1.01 mg/L 1.37128712871287 -DTXSID1047493 Css 3compartmentss Human 95% 2.928 mg/L 2.21 mg/L 1.32488687782805 -DTXSID1047497 Css 3compartmentss Human 95% 0.6647 mg/L 8e-09 mg/L 83087500 -DTXSID1047524 Css 3compartmentss Human 95% 5.51 mg/L 3.307 mg/L 1.66616268521318 -DTXSID1047526 Css 3compartmentss Human 95% 0.4998 mg/L 0 mg/L Inf -DTXSID1047528 Css 3compartmentss Human 95% 42.09 mg/L 0.1226 mg/L 343.311582381729 -DTXSID1047570 Css 3compartmentss Human 95% 2.311 mg/L 2.222 mg/L 1.04005400540054 -DTXSID1047601 Css 3compartmentss Human 95% 1.631 mg/L 1.536 mg/L 1.06184895833333 -DTXSID1047605 Css 3compartmentss Human 95% 11.01 mg/L 3.484 mg/L 3.1601607347876 -DTXSID1047609 Css 3compartmentss Human 95% 8.504 mg/L 5.848 mg/L 1.45417236662107 -DTXSID1047657 Css 3compartmentss Human 95% 2.877 mg/L 2.927 mg/L 0.982917663136317 -DTXSID1047730 Css 3compartmentss Human 95% 11.82 mg/L 3.761 mg/L 3.14278117521936 -DTXSID1047780 Css 3compartmentss Human 95% 0.3793 mg/L 0.2628 mg/L 1.44330289193303 -DTXSID1047782 Css 3compartmentss Human 95% 0.3881 mg/L 0.2062 mg/L 1.88215324927255 -DTXSID1047784 Css 3compartmentss Human 95% 2.256 mg/L 0.8232 mg/L 2.74052478134111 -DTXSID1047786 Css 3compartmentss Human 95% 0.7269 mg/L 0.3777 mg/L 1.92454328832407 -DTXSID1047788 Css 3compartmentss Human 95% 1.115 mg/L 0.7154 mg/L 1.55856863293262 -DTXSID1047811 Css 3compartmentss Human 95% 4.253 mg/L 0.5943 mg/L 7.15631835773179 -DTXSID1047813 Css 3compartmentss Human 95% 0.07402 mg/L 0.04063 mg/L 1.82180654688654 -DTXSID1047815 Css 3compartmentss Human 95% 0.1102 mg/L 0.07602 mg/L 1.44961852144173 -DTXSID1047817 Css 3compartmentss Human 95% 7.718 mg/L 5.051 mg/L 1.52801425460305 -DTXSID1047819 Css 3compartmentss Human 95% 2.695 mg/L 0.4931 mg/L 5.46542283512472 -DTXSID1047869 Css 3compartmentss Human 95% 0.003941 mg/L 0.003631 mg/L 1.08537592949601 -DTXSID1047940 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID1047942 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID1047944 Css 3compartmentss Human 95% 0.00673 mg/L 0 mg/L Inf -DTXSID1048122 Css 3compartmentss Human 95% 4.079 mg/L 1.797 mg/L 2.26989426822482 -DTXSID1048170 Css 3compartmentss Human 95% 46.27 mg/L 0.004271 mg/L 10833.5284476703 -DTXSID1048172 Css 3compartmentss Human 95% 3.742 mg/L 1.971 mg/L 1.89852866565195 -DTXSID1048174 Css 3compartmentss Human 95% 20.08 mg/L 3.152 mg/L 6.37055837563452 -DTXSID1048178 Css 3compartmentss Human 95% 351.8 mg/L 151.4 mg/L 2.32364597093791 -DTXSID1048201 Css 3compartmentss Human 95% 2.624 mg/L 2.572 mg/L 1.02021772939347 -DTXSID1048203 Css 3compartmentss Human 95% 1.976 mg/L 1.586 mg/L 1.24590163934426 -DTXSID1048207 Css 3compartmentss Human 95% 27.57 mg/L 14.88 mg/L 1.85282258064516 -DTXSID1048259 Css 3compartmentss Human 95% 7.424 mg/L 4.838 mg/L 1.53451839603142 -DTXSID1048384 Css 3compartmentss Human 95% 47.09 mg/L 4.35 mg/L 10.8252873563218 -DTXSID1048590 Css 3compartmentss Human 95% 0.556 mg/L 0.3291 mg/L 1.68945609237314 -DTXSID1048592 Css 3compartmentss Human 95% 6.064 mg/L 3.878 mg/L 1.56369262506447 -DTXSID1048594 Css 3compartmentss Human 95% 8.31 mg/L 5.178 mg/L 1.60486674391657 -DTXSID1048596 Css 3compartmentss Human 95% 70.98 mg/L 35.84 mg/L 1.98046875 -DTXSID1048598 Css 3compartmentss Human 95% 4.14 mg/L 1.284 mg/L 3.22429906542056 -DTXSID1048621 Css 3compartmentss Human 95% 0.2177 mg/L 0.09506 mg/L 2.29013254786451 -DTXSID1048623 Css 3compartmentss Human 95% 0.0008432 mg/L 0 mg/L Inf -DTXSID1048625 Css 3compartmentss Human 95% 47.14 mg/L 20.28 mg/L 2.32445759368836 -DTXSID1048627 Css 3compartmentss Human 95% 44.19 mg/L 20.85 mg/L 2.11942446043165 -DTXSID1048629 Css 3compartmentss Human 95% 14.2 mg/L 8.682 mg/L 1.63556784151117 -DTXSID1048671 Css 3compartmentss Human 95% 4.991 mg/L 1.295 mg/L 3.85405405405405 -DTXSID1048675 Css 3compartmentss Human 95% 5.933 mg/L 3.798 mg/L 1.56213796735124 -DTXSID1048677 Css 3compartmentss Human 95% 1.26 mg/L 0.743 mg/L 1.69582772543742 -DTXSID1048679 Css 3compartmentss Human 95% 18.31 mg/L 2.147 mg/L 8.52817885421518 -DTXSID1048700 Css 3compartmentss Human 95% 0.4739 mg/L 0.002274 mg/L 208.399296394019 -DTXSID1048704 Css 3compartmentss Human 95% 5.667 mg/L 3.628 mg/L 1.56201764057332 -DTXSID1048706 Css 3compartmentss Human 95% 5.977 mg/L 3.894 mg/L 1.53492552645095 -DTXSID1048708 Css 3compartmentss Human 95% 18.87 mg/L 3.999 mg/L 4.71867966991748 -DTXSID1048750 Css 3compartmentss Human 95% 0.5398 mg/L 0.3764 mg/L 1.43411264612115 -DTXSID1048754 Css 3compartmentss Human 95% NA mg/L NA mg/L NA -DTXSID1048756 Css 3compartmentss Human 95% 2.642 mg/L 1.676 mg/L 1.5763723150358 -DTXSID1048758 Css 3compartmentss Human 95% 2.555 mg/L 1.161 mg/L 2.20068906115418 -DTXSID1048831 Css 3compartmentss Human 95% 3.529 mg/L 1.74 mg/L 2.02816091954023 -DTXSID1048833 Css 3compartmentss Human 95% 2.736 mg/L 2.942 mg/L 0.929979605710401 -DTXSID1048835 Css 3compartmentss Human 95% 8.365 mg/L 1.141 mg/L 7.33128834355828 -DTXSID1048837 Css 3compartmentss Human 95% 0.5227 mg/L 0.3847 mg/L 1.3587210813621 -DTXSID1048839 Css 3compartmentss Human 95% 5.098 mg/L 0.5192 mg/L 9.81895223420647 -DTXSID1048881 Css 3compartmentss Human 95% 0.08216 mg/L 0.05722 mg/L 1.43586158685774 -DTXSID1048883 Css 3compartmentss Human 95% 0.06732 mg/L 0.0502 mg/L 1.34103585657371 -DTXSID1048885 Css 3compartmentss Human 95% 0.02434 mg/L 0.01878 mg/L 1.29605963791267 -DTXSID1048887 Css 3compartmentss Human 95% 0.03987 mg/L 0.03 mg/L 1.329 -DTXSID1048889 Css 3compartmentss Human 95% 0.02779 mg/L 0.01848 mg/L 1.50378787878788 -DTXSID1048910 Css 3compartmentss Human 95% 0.8046 mg/L 0.4638 mg/L 1.73479948253558 -DTXSID1048912 Css 3compartmentss Human 95% 4.053 mg/L 2.195 mg/L 1.84646924829157 -DTXSID1048914 Css 3compartmentss Human 95% 0.5678 mg/L 0.4046 mg/L 1.40336134453782 -DTXSID1048916 Css 3compartmentss Human 95% 1.583 mg/L 0.2951 mg/L 5.36428329379871 -DTXSID1048918 Css 3compartmentss Human 95% 0.7579 mg/L 0.2647 mg/L 2.86324140536456 -DTXSID1048960 Css 3compartmentss Human 95% 6.878 mg/L 3.855 mg/L 1.78417639429313 -DTXSID1048962 Css 3compartmentss Human 95% 6.569 mg/L 4.175 mg/L 1.57341317365269 -DTXSID1048964 Css 3compartmentss Human 95% 7.397 mg/L 4.152 mg/L 1.78155105973025 -DTXSID1048966 Css 3compartmentss Human 95% NA mg/L 0 mg/L NA -DTXSID1048968 Css 3compartmentss Human 95% 0.3737 mg/L 0.004873 mg/L 76.6878719474656 -DTXSID1049015 Css 3compartmentss Human 95% 18.96 mg/L 1.011 mg/L 18.7537091988131 -DTXSID1049017 Css 3compartmentss Human 95% 0.05926 mg/L 0.04806 mg/L 1.23304203079484 -DTXSID1049019 Css 3compartmentss Human 95% 4.241 mg/L 2.834 mg/L 1.49647141848977 -DTXSID1049061 Css 3compartmentss Human 95% 5.75 mg/L 3.628 mg/L 1.58489525909592 -DTXSID1049063 Css 3compartmentss Human 95% 1.829 mg/L 1.537 mg/L 1.18998048145738 -DTXSID1049065 Css 3compartmentss Human 95% 0.9387 mg/L 0.2249 mg/L 4.17385504668742 -DTXSID1049067 Css 3compartmentss Human 95% 5.689 mg/L 1.915 mg/L 2.97075718015666 -DTXSID1049069 Css 3compartmentss Human 95% 14.6 mg/L 8.723 mg/L 1.67373609996561 -DTXSID1049221 Css 3compartmentss Human 95% 6.033 mg/L 2.587 mg/L 2.33204483958253 -DTXSID1049223 Css 3compartmentss Human 95% 7.569 mg/L 4.86 mg/L 1.55740740740741 -DTXSID1049225 Css 3compartmentss Human 95% 0.2848 mg/L 0.1676 mg/L 1.69928400954654 -DTXSID1049227 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID1049229 Css 3compartmentss Human 95% 2.582 mg/L 0.01295 mg/L 199.382239382239 -DTXSID1049271 Css 3compartmentss Human 95% 16.61 mg/L 0.6039 mg/L 27.5045537340619 -DTXSID1049273 Css 3compartmentss Human 95% 16.87 mg/L 0.1724 mg/L 97.8538283062645 -DTXSID1049277 Css 3compartmentss Human 95% 2.122 mg/L 1.756 mg/L 1.20842824601367 -DTXSID1049304 Css 3compartmentss Human 95% 4.386e-06 mg/L NA NA NA -DTXSID1049306 Css 3compartmentss Human 95% 7.71 mg/L 4.87 mg/L 1.58316221765914 -DTXSID1049308 Css 3compartmentss Human 95% 3.202 mg/L 3.689 mg/L 0.867985904039035 -DTXSID1049352 Css 3compartmentss Human 95% 0.9256 mg/L 8.461e-05 mg/L 10939.6052476067 -DTXSID1049354 Css 3compartmentss Human 95% 290.3 mg/L 177.6 mg/L 1.63457207207207 -DTXSID1049358 Css 3compartmentss Human 95% 5.578 mg/L 3.554 mg/L 1.5694991558807 -DTXSID1049431 Css 3compartmentss Human 95% 16.71 mg/L 11.38 mg/L 1.46836555360281 -DTXSID1049433 Css 3compartmentss Human 95% 2.646 mg/L 1.652 mg/L 1.60169491525424 -DTXSID1049697 Css 3compartmentss Human 95% 7.647 mg/L 0.01292 mg/L 591.87306501548 -DTXSID1051690 Css 3compartmentss Human 95% 0.5101 mg/L 0.3325 mg/L 1.53413533834586 -DTXSID1051808 Css 3compartmentss Human 95% 0.8058 mg/L 0.4794 mg/L 1.68085106382979 -DTXSID1051850 Css 3compartmentss Human 95% 7.057 mg/L 4.678 mg/L 1.50855066267636 -DTXSID1051856 Css 3compartmentss Human 95% 3.195 mg/L 2.198 mg/L 1.45359417652411 -DTXSID1051939 Css 3compartmentss Human 95% 3.133 mg/L 1.96 mg/L 1.5984693877551 -DTXSID1052294 Css 3compartmentss Human 95% 0.1359 mg/L 0.1055 mg/L 1.28815165876777 -DTXSID1052298 Css 3compartmentss Human 95% 1.978 mg/L 1.096 mg/L 1.80474452554745 -DTXSID1057610 Css 3compartmentss Human 95% 18.7 mg/L 5.745 mg/L 3.2550043516101 -DTXSID1057612 Css 3compartmentss Human 95% 4.172 mg/L 5.518 mg/L 0.756071040231968 -DTXSID1057614 Css 3compartmentss Human 95% 0.1183 mg/L 0.08655 mg/L 1.36683997689197 -DTXSID1057616 Css 3compartmentss Human 95% 1.715 mg/L 1.074 mg/L 1.59683426443203 -DTXSID1057618 Css 3compartmentss Human 95% 10.89 mg/L 6.7 mg/L 1.62537313432836 -DTXSID1057660 Css 3compartmentss Human 95% 7.574 mg/L 3.943 mg/L 1.92087243215826 -DTXSID1057662 Css 3compartmentss Human 95% 0.458 mg/L 0.001025 mg/L 446.829268292683 -DTXSID1057664 Css 3compartmentss Human 95% 110.1 mg/L 60.09 mg/L 1.83225162256615 -DTXSID1057666 Css 3compartmentss Human 95% 0.3193 mg/L 0.2056 mg/L 1.55301556420233 -DTXSID1057668 Css 3compartmentss Human 95% 7.87 mg/L 4.367 mg/L 1.80215250744218 -DTXSID1057741 Css 3compartmentss Human 95% 6.389 mg/L 3.814 mg/L 1.67514420555847 -DTXSID1057743 Css 3compartmentss Human 95% 9.293 mg/L 5.815 mg/L 1.59810834049871 -DTXSID1057745 Css 3compartmentss Human 95% 4.912 mg/L 1.396 mg/L 3.51862464183381 -DTXSID1057747 Css 3compartmentss Human 95% 11.04 mg/L 5.28 mg/L 2.09090909090909 -DTXSID1057749 Css 3compartmentss Human 95% 9.346 mg/L 1.33 mg/L 7.02706766917293 -DTXSID1057791 Css 3compartmentss Human 95% 16.25 mg/L 9.247 mg/L 1.75732670055153 -DTXSID1057793 Css 3compartmentss Human 95% 1.26 mg/L 0.8761 mg/L 1.43819198721607 -DTXSID1057795 Css 3compartmentss Human 95% 0.2189 mg/L 0.1376 mg/L 1.59084302325581 -DTXSID1057797 Css 3compartmentss Human 95% 15.48 mg/L 9.305 mg/L 1.66362170875873 -DTXSID1057799 Css 3compartmentss Human 95% 2.422 mg/L 1.564 mg/L 1.54859335038363 -DTXSID1057820 Css 3compartmentss Human 95% 0.1706 mg/L 0.1102 mg/L 1.5480943738657 -DTXSID1057822 Css 3compartmentss Human 95% 79.19 mg/L 65.88 mg/L 1.20203400121433 -DTXSID1057824 Css 3compartmentss Human 95% 3.207 mg/L 1.548 mg/L 2.07170542635659 -DTXSID1057826 Css 3compartmentss Human 95% 9.918 mg/L 5.435 mg/L 1.82483900643974 -DTXSID1057828 Css 3compartmentss Human 95% 10.42 mg/L 6.927 mg/L 1.504258697849 -DTXSID10858817 Css 3compartmentss Human 95% 0.1022 mg/L 0.06371 mg/L 1.60414377648721 -DTXSID10859960 Css 3compartmentss Human 95% 2.655 mg/L 0.79 mg/L 3.36075949367089 -DTXSID2020006 Css 3compartmentss Human 95% 1.411 mg/L 1.092 mg/L 1.29212454212454 -DTXSID2020054 Css 3compartmentss Human 95% 6.266 mg/L 3.714 mg/L 1.68712977921379 -DTXSID2020131 Css 3compartmentss Human 95% 12.83 mg/L 7.718 mg/L 1.66234775848665 -DTXSID2020137 Css 3compartmentss Human 95% 1.961 mg/L 1.166 mg/L 1.68181818181818 -DTXSID2020139 Css 3compartmentss Human 95% 105.3 mg/L 0.01861 mg/L 5658.24825362708 -DTXSID2020181 Css 3compartmentss Human 95% 5.298 mg/L 3.771 mg/L 1.4049323786794 -DTXSID2020189 Css 3compartmentss Human 95% 28.31 mg/L 14.77 mg/L 1.9167230873392 -DTXSID2020210 Css 3compartmentss Human 95% 1.799 mg/L 1.159 mg/L 1.55220017256255 -DTXSID2020212 Css 3compartmentss Human 95% 6.532 mg/L 2.696 mg/L 2.42284866468843 -DTXSID2020216 Css 3compartmentss Human 95% 81.13 mg/L 2.123 mg/L 38.2147903909562 -DTXSID2020260 Css 3compartmentss Human 95% 111.1 mg/L 65.74 mg/L 1.6899908731366 -DTXSID2020262 Css 3compartmentss Human 95% 97.92 mg/L 57.29 mg/L 1.70919881305638 -DTXSID2020268 Css 3compartmentss Human 95% 239 mg/L 139.6 mg/L 1.71203438395415 -DTXSID2020341 Css 3compartmentss Human 95% 0.2083 mg/L 0.1471 mg/L 1.41604350781781 -DTXSID2020345 Css 3compartmentss Human 95% 7.282 mg/L 4.559 mg/L 1.59728010528625 -DTXSID2020347 Css 3compartmentss Human 95% 15.92 mg/L 4.003 mg/L 3.9770172370722 -DTXSID2020349 Css 3compartmentss Human 95% 0.1339 mg/L 0.08494 mg/L 1.57640687544149 -DTXSID2020391 Css 3compartmentss Human 95% 12.05 mg/L 1.904 mg/L 6.32878151260504 -DTXSID2020399 Css 3compartmentss Human 95% 2.201 mg/L 1.274 mg/L 1.7276295133438 -DTXSID2020420 Css 3compartmentss Human 95% 12.53 mg/L 8.91 mg/L 1.40628507295174 -DTXSID2020424 Css 3compartmentss Human 95% 6.167 mg/L 3.88 mg/L 1.58943298969072 -DTXSID2020426 Css 3compartmentss Human 95% 24.33 mg/L 33.82 mg/L 0.7193968066233 -DTXSID2020428 Css 3compartmentss Human 95% 7.163 mg/L 4.662 mg/L 1.53646503646504 -DTXSID2020470 Css 3compartmentss Human 95% 0.05683 mg/L 0.03507 mg/L 1.62047333903621 -DTXSID2020474 Css 3compartmentss Human 95% 1.097 mg/L 0.7212 mg/L 1.52107598447033 -DTXSID2020478 Css 3compartmentss Human 95% 7.273 mg/L 4.375 mg/L 1.6624 -DTXSID2020501 Css 3compartmentss Human 95% 15.42 mg/L 10.2 mg/L 1.51176470588235 -DTXSID2020505 Css 3compartmentss Human 95% 3.35 mg/L 2.343 mg/L 1.42979086641058 -DTXSID2020507 Css 3compartmentss Human 95% 0.4465 mg/L 0.3499 mg/L 1.27607887967991 -DTXSID2020509 Css 3compartmentss Human 95% 5.015 mg/L 3.389 mg/L 1.47978754794925 -DTXSID2020557 Css 3compartmentss Human 95% 238.9 mg/L 140.4 mg/L 1.70156695156695 -DTXSID2020634 Css 3compartmentss Human 95% 5.94 mg/L 4.082 mg/L 1.45516903478687 -DTXSID2020636 Css 3compartmentss Human 95% 214.2 mg/L 81.57 mg/L 2.62596542846635 -DTXSID2020680 Css 3compartmentss Human 95% 0.9499 mg/L 0.6353 mg/L 1.49519911852668 -DTXSID2020684 Css 3compartmentss Human 95% 114.7 mg/L 135.5 mg/L 0.846494464944649 -DTXSID2020686 Css 3compartmentss Human 95% 265.2 mg/L 158.3 mg/L 1.67530006317119 -DTXSID2020713 Css 3compartmentss Human 95% 3.049 mg/L 3.636 mg/L 0.838558855885589 -DTXSID2020717 Css 3compartmentss Human 95% 1.683 mg/L 0.9044 mg/L 1.8609022556391 -DTXSID2020846 Css 3compartmentss Human 95% 6.675 mg/L 3.737 mg/L 1.78619213272679 -DTXSID2020890 Css 3compartmentss Human 95% 7.14 mg/L 4.692 mg/L 1.52173913043478 -DTXSID2020892 Css 3compartmentss Human 95% 1.022 mg/L 0.5219 mg/L 1.95822954589002 -DTXSID2020894 Css 3compartmentss Human 95% 6.363 mg/L 1.99 mg/L 3.19748743718593 -DTXSID2020898 Css 3compartmentss Human 95% 5.202 mg/L 3.244 mg/L 1.6035758323058 -DTXSID2020921 Css 3compartmentss Human 95% 2.46 mg/L 1.288 mg/L 1.90993788819876 -DTXSID2020923 Css 3compartmentss Human 95% 1.873 mg/L 1.224 mg/L 1.53022875816993 -DTXSID2020927 Css 3compartmentss Human 95% 3.443 mg/L 1.818 mg/L 1.89383938393839 -DTXSID2020929 Css 3compartmentss Human 95% 2.746 mg/L 1.757 mg/L 1.56289129197496 -DTXSID2020977 Css 3compartmentss Human 95% 8.287 mg/L 5.542 mg/L 1.495308552869 -DTXSID2021022 Css 3compartmentss Human 95% 1.037 mg/L 0.7507 mg/L 1.38137738111096 -DTXSID2021028 Css 3compartmentss Human 95% 4.874 mg/L 3.104 mg/L 1.57023195876289 -DTXSID2021070 Css 3compartmentss Human 95% 11.39 mg/L 8.405 mg/L 1.35514574657942 -DTXSID2021151 Css 3compartmentss Human 95% 147.9 mg/L 135.3 mg/L 1.09312638580931 -DTXSID2021159 Css 3compartmentss Human 95% 1.359 mg/L 1.079 mg/L 1.25949953660797 -DTXSID2021232 Css 3compartmentss Human 95% 7.964 mg/L 4.223 mg/L 1.88586313047597 -DTXSID2021234 Css 3compartmentss Human 95% 4.902 mg/L 2.566 mg/L 1.9103663289166 -DTXSID2021236 Css 3compartmentss Human 95% 0.3445 mg/L 0.2099 mg/L 1.6412577417818 -DTXSID2021238 Css 3compartmentss Human 95% 0.3957 mg/L 0.2899 mg/L 1.36495343221801 -DTXSID2021282 Css 3compartmentss Human 95% 3.268 mg/L 2.154 mg/L 1.51717734447539 -DTXSID2021286 Css 3compartmentss Human 95% 1.238 mg/L 0.7576 mg/L 1.63410770855333 -DTXSID2021288 Css 3compartmentss Human 95% 5.151 mg/L 3.315 mg/L 1.55384615384615 -DTXSID2021311 Css 3compartmentss Human 95% 13.98 mg/L 0.2041 mg/L 68.4958353748163 -DTXSID2021315 Css 3compartmentss Human 95% 8145 mg/L 9739 mg/L 0.836328165109354 -DTXSID2021363 Css 3compartmentss Human 95% 1.801 mg/L 1.091 mg/L 1.65077910174152 -DTXSID2021365 Css 3compartmentss Human 95% 1.139 mg/L 0.6938 mg/L 1.64168348227155 -DTXSID2021367 Css 3compartmentss Human 95% 0.1779 mg/L 0.0001582 mg/L 1124.52591656131 -DTXSID2021440 Css 3compartmentss Human 95% 1.982 mg/L 1.665 mg/L 1.19039039039039 -DTXSID2021442 Css 3compartmentss Human 95% 4.588 mg/L 3.269 mg/L 1.40348730498623 -DTXSID2021446 Css 3compartmentss Human 95% 4.776 mg/L 4.762 mg/L 1.00293994120118 -DTXSID2021448 Css 3compartmentss Human 95% 1.051 mg/L 0.6945 mg/L 1.51331893448524 -DTXSID2021492 Css 3compartmentss Human 95% 4.373 mg/L 3.374 mg/L 1.29608772969769 -DTXSID2021498 Css 3compartmentss Human 95% 5.806 mg/L 4.541 mg/L 1.27857300154151 -DTXSID2021575 Css 3compartmentss Human 95% 8.362 mg/L 5.371 mg/L 1.55687953826103 -DTXSID2021577 Css 3compartmentss Human 95% 5.338 mg/L 3.662 mg/L 1.45767340251229 -DTXSID2021600 Css 3compartmentss Human 95% 8.437 mg/L 5.434 mg/L 1.55263157894737 -DTXSID2021602 Css 3compartmentss Human 95% 663.3 mg/L 3846 mg/L 0.172464898595944 -DTXSID2021650 Css 3compartmentss Human 95% 7.522 mg/L 4.721 mg/L 1.59330650285956 -DTXSID2021652 Css 3compartmentss Human 95% 571.4 mg/L 1542 mg/L 0.370557717250324 -DTXSID2021654 Css 3compartmentss Human 95% 8.153 mg/L 5.06 mg/L 1.61126482213439 -DTXSID2021656 Css 3compartmentss Human 95% 15.31 mg/L 9.226 mg/L 1.65944071103403 -DTXSID2021731 Css 3compartmentss Human 95% 1.421 mg/L 0.9443 mg/L 1.50481838398814 -DTXSID2021735 Css 3compartmentss Human 95% 5.558 mg/L 3.261 mg/L 1.70438515792702 -DTXSID2021739 Css 3compartmentss Human 95% 6.692 mg/L 4.272 mg/L 1.56647940074906 -DTXSID2021781 Css 3compartmentss Human 95% 5.706 mg/L 0.6365 mg/L 8.96465043205028 -DTXSID2021789 Css 3compartmentss Human 95% 0.1013 mg/L 0.04725 mg/L 2.14391534391534 -DTXSID2021810 Css 3compartmentss Human 95% 1.338 mg/L 0.9275 mg/L 1.44258760107817 -DTXSID2021864 Css 3compartmentss Human 95% 1.249 mg/L 0.9183 mg/L 1.36012196449962 -DTXSID2021866 Css 3compartmentss Human 95% 6.368 mg/L 3.309 mg/L 1.92444847385917 -DTXSID2021941 Css 3compartmentss Human 95% 3.247 mg/L 2.352 mg/L 1.38052721088435 -DTXSID2021947 Css 3compartmentss Human 95% 12.06 mg/L 0.07179 mg/L 167.989970748015 -DTXSID2021949 Css 3compartmentss Human 95% 4.977 mg/L 3.32 mg/L 1.49909638554217 -DTXSID2021995 Css 3compartmentss Human 95% 1.97 mg/L 1.463 mg/L 1.34654818865345 -DTXSID2021997 Css 3compartmentss Human 95% 2.614 mg/L 1.746 mg/L 1.4971363115693 -DTXSID2022048 Css 3compartmentss Human 95% 15.2 mg/L 8.42 mg/L 1.80522565320665 -DTXSID2022090 Css 3compartmentss Human 95% 4.887 mg/L 3.486 mg/L 1.40189328743546 -DTXSID2022121 Css 3compartmentss Human 95% 34.88 mg/L 21.85 mg/L 1.59633867276888 -DTXSID2022123 Css 3compartmentss Human 95% 3.023 mg/L 3.214 mg/L 0.940572495332919 -DTXSID2022127 Css 3compartmentss Human 95% 4.641 mg/L 2.957 mg/L 1.56949611092323 -DTXSID2022254 Css 3compartmentss Human 95% 7.234 mg/L 1.352 mg/L 5.35059171597633 -DTXSID2022256 Css 3compartmentss Human 95% 23.2 mg/L 16.31 mg/L 1.42244022072348 -DTXSID2022331 Css 3compartmentss Human 95% 3.101 mg/L 2.222 mg/L 1.3955895589559 -DTXSID2022381 Css 3compartmentss Human 95% 9.307 mg/L 3.545 mg/L 2.62538787023977 -DTXSID2022462 Css 3compartmentss Human 95% 9.538 mg/L 5.127 mg/L 1.86034718158767 -DTXSID2022541 Css 3compartmentss Human 95% 60 mg/L 31.33 mg/L 1.915097350782 -DTXSID2022543 Css 3compartmentss Human 95% 3.613 mg/L 2.224 mg/L 1.62455035971223 -DTXSID2022549 Css 3compartmentss Human 95% 60.91 mg/L 34.3 mg/L 1.77580174927114 -DTXSID2022593 Css 3compartmentss Human 95% 0.3717 mg/L 0.2377 mg/L 1.56373580143037 -DTXSID2022595 Css 3compartmentss Human 95% 44.94 mg/L 24.14 mg/L 1.86164043082022 -DTXSID2022624 Css 3compartmentss Human 95% 2.182 mg/L 1.518 mg/L 1.43741765480896 -DTXSID2022626 Css 3compartmentss Human 95% 10.37 mg/L 6.062 mg/L 1.71065654899373 -DTXSID2022628 Css 3compartmentss Human 95% 0.7776 mg/L 0.5198 mg/L 1.49595998460946 -DTXSID2022672 Css 3compartmentss Human 95% 15.53 mg/L 9.477 mg/L 1.63870423129682 -DTXSID2022674 Css 3compartmentss Human 95% 1.678 mg/L 0.9899 mg/L 1.69512071926457 -DTXSID2022676 Css 3compartmentss Human 95% 3.351 mg/L 3.361 mg/L 0.997024695031241 -DTXSID2022678 Css 3compartmentss Human 95% 132.2 mg/L 80.08 mg/L 1.65084915084915 -DTXSID2022703 Css 3compartmentss Human 95% 7.354 mg/L 3.966 mg/L 1.85426122037317 -DTXSID2022707 Css 3compartmentss Human 95% 10.59 mg/L 6.324 mg/L 1.67457305502846 -DTXSID2022751 Css 3compartmentss Human 95% 9.3 mg/L 5.359 mg/L 1.73539839522299 -DTXSID2022753 Css 3compartmentss Human 95% 17.84 mg/L 10.5 mg/L 1.69904761904762 -DTXSID2022759 Css 3compartmentss Human 95% 15.45 mg/L 8.39 mg/L 1.84147794994041 -DTXSID2022880 Css 3compartmentss Human 95% 11.71 mg/L 4.176 mg/L 2.80411877394636 -DTXSID2022888 Css 3compartmentss Human 95% 6.418 mg/L 3.514 mg/L 1.82640865110985 -DTXSID2022915 Css 3compartmentss Human 95% 5.505 mg/L 3.307 mg/L 1.66465074085274 -DTXSID2022967 Css 3compartmentss Human 95% 8.882 mg/L 5.337 mg/L 1.66423084129661 -DTXSID2023010 Css 3compartmentss Human 95% 1.212 mg/L 0.7695 mg/L 1.57504873294347 -DTXSID2023016 Css 3compartmentss Human 95% 6.506 mg/L 4.187 mg/L 1.55385717697636 -DTXSID2023064 Css 3compartmentss Human 95% 0.3078 mg/L 0.2069 mg/L 1.48767520541324 -DTXSID2023068 Css 3compartmentss Human 95% 3.006 mg/L 0.5667 mg/L 5.30439385918475 -DTXSID2023143 Css 3compartmentss Human 95% 5.562 mg/L 3.676 mg/L 1.51305767138194 -DTXSID2023145 Css 3compartmentss Human 95% 8.176 mg/L 4.332 mg/L 1.88734995383195 -DTXSID2023149 Css 3compartmentss Human 95% 9.18 mg/L 4.999 mg/L 1.83636727345469 -DTXSID2023191 Css 3compartmentss Human 95% 0.8216 mg/L 0.6303 mg/L 1.30350626685705 -DTXSID2023193 Css 3compartmentss Human 95% 5.284 mg/L 3.388 mg/L 1.55962219598583 -DTXSID2023195 Css 3compartmentss Human 95% 2.847 mg/L 1.677 mg/L 1.69767441860465 -DTXSID2023197 Css 3compartmentss Human 95% 14.63 mg/L 8.79 mg/L 1.66439135381115 -DTXSID2023222 Css 3compartmentss Human 95% 1.447 mg/L 0.9184 mg/L 1.57556620209059 -DTXSID2023224 Css 3compartmentss Human 95% 11.08 mg/L 0.7556 mg/L 14.6638433033351 -DTXSID2023226 Css 3compartmentss Human 95% 9.854 mg/L 0.4552 mg/L 21.6476274165202 -DTXSID2023270 Css 3compartmentss Human 95% 2.652 mg/L 1.813 mg/L 1.46276889134032 -DTXSID2023276 Css 3compartmentss Human 95% 7.924 mg/L 5.383 mg/L 1.47204161248375 -DTXSID2023303 Css 3compartmentss Human 95% 6.053 mg/L 3.76 mg/L 1.60984042553191 -DTXSID2023307 Css 3compartmentss Human 95% 2.047 mg/L 1.119 mg/L 1.82931188561215 -DTXSID2023309 Css 3compartmentss Human 95% 0.6282 mg/L 0.4207 mg/L 1.49322557642025 -DTXSID2023353 Css 3compartmentss Human 95% 1.952 mg/L 2.086e-06 mg/L 935762.224352828 -DTXSID2023430 Css 3compartmentss Human 95% 40.92 mg/L 24.25 mg/L 1.68742268041237 -DTXSID2023434 Css 3compartmentss Human 95% 5.261 mg/L 3.628 mg/L 1.45011025358324 -DTXSID2023436 Css 3compartmentss Human 95% 4.762 mg/L 3.334 mg/L 1.42831433713257 -DTXSID2023480 Css 3compartmentss Human 95% 4.504 mg/L 2.165 mg/L 2.08036951501155 -DTXSID2023488 Css 3compartmentss Human 95% 14.12 mg/L 7.349 mg/L 1.92134984351612 -DTXSID2023517 Css 3compartmentss Human 95% 12.54 mg/L 0.6866 mg/L 18.26390911739 -DTXSID2023519 Css 3compartmentss Human 95% 25.72 mg/L 2.433 mg/L 10.5713111385121 -DTXSID2023565 Css 3compartmentss Human 95% 0.6023 mg/L 0.4741 mg/L 1.27040708711242 -DTXSID2023567 Css 3compartmentss Human 95% 6.219 mg/L 4.311 mg/L 1.44258872651357 -DTXSID2023569 Css 3compartmentss Human 95% 7.67 mg/L 3.891 mg/L 1.97121562580314 -DTXSID2023640 Css 3compartmentss Human 95% 4.526 mg/L 0.002041 mg/L 2217.54042136208 -DTXSID2023642 Css 3compartmentss Human 95% 0.4276 mg/L 0.004508 mg/L 94.8535936113576 -DTXSID2023644 Css 3compartmentss Human 95% 3.257 mg/L 2.653 mg/L 1.22766679231059 -DTXSID2023690 Css 3compartmentss Human 95% 30.78 mg/L 14.41 mg/L 2.13601665510062 -DTXSID2023692 Css 3compartmentss Human 95% 18.39 mg/L 10.61 mg/L 1.73327049952875 -DTXSID2023721 Css 3compartmentss Human 95% 0.04982 mg/L 0.0356 mg/L 1.39943820224719 -DTXSID2023723 Css 3compartmentss Human 95% 2.823 mg/L 2.141 mg/L 1.31854273703877 -DTXSID2023725 Css 3compartmentss Human 95% 0.04594 mg/L 0.03268 mg/L 1.40575275397797 -DTXSID2023727 Css 3compartmentss Human 95% 99.16 mg/L 0.09654 mg/L 1027.1390097369 -DTXSID2023729 Css 3compartmentss Human 95% 48.35 mg/L 24.75 mg/L 1.95353535353535 -DTXSID2023771 Css 3compartmentss Human 95% 6.607 mg/L 4.198 mg/L 1.57384468794664 -DTXSID2023775 Css 3compartmentss Human 95% 30.95 mg/L 17.77 mg/L 1.74169949352842 -DTXSID2024038 Css 3compartmentss Human 95% 6.232 mg/L 4.294 mg/L 1.45132743362832 -DTXSID2024086 Css 3compartmentss Human 95% 223.9 mg/L 2.002 mg/L 111.838161838162 -DTXSID2024113 Css 3compartmentss Human 95% 11.86 mg/L 4.708 mg/L 2.51911639762107 -DTXSID2024163 Css 3compartmentss Human 95% 1.82 mg/L 1.077 mg/L 1.68987929433612 -DTXSID2024242 Css 3compartmentss Human 95% 5.018 mg/L 3.988 mg/L 1.25827482447342 -DTXSID2024452 Css 3compartmentss Human 95% 3.871 mg/L 2.494 mg/L 1.55212510024058 -DTXSID2024454 Css 3compartmentss Human 95% 1.67 mg/L 1.227 mg/L 1.36104319478403 -DTXSID2024458 Css 3compartmentss Human 95% 6.829 mg/L 3.227 mg/L 2.11620700340874 -DTXSID2024616 Css 3compartmentss Human 95% 59.37 mg/L 5.562 mg/L 10.6742179072276 -DTXSID2024662 Css 3compartmentss Human 95% 0.6652 mg/L 0.4255 mg/L 1.56333725029377 -DTXSID2024664 Css 3compartmentss Human 95% 5.746 mg/L 3.748 mg/L 1.53308431163287 -DTXSID2024666 Css 3compartmentss Human 95% 2.934 mg/L 3.284 mg/L 0.893422655298417 -DTXSID2024747 Css 3compartmentss Human 95% 2.9 mg/L 1.624 mg/L 1.78571428571429 -DTXSID2024797 Css 3compartmentss Human 95% 7.683 mg/L 4.841 mg/L 1.58706878744061 -DTXSID2024824 Css 3compartmentss Human 95% 2.386 mg/L 8.529e-05 mg/L 27975.1436276234 -DTXSID2024878 Css 3compartmentss Human 95% 5.343 mg/L 3.534 mg/L 1.51188455008489 -DTXSID2024953 Css 3compartmentss Human 95% 0.4143 mg/L 0.2938 mg/L 1.41014295439074 -DTXSID2025004 Css 3compartmentss Human 95% 163.6 mg/L 94.52 mg/L 1.73085061362675 -DTXSID2025006 Css 3compartmentss Human 95% 5.222 mg/L 3.237 mg/L 1.61322211924622 -DTXSID2025050 Css 3compartmentss Human 95% 0.6218 mg/L 0.548 mg/L 1.13467153284672 -DTXSID2025058 Css 3compartmentss Human 95% 0.3819 mg/L 0.2778 mg/L 1.37473002159827 -DTXSID2025133 Css 3compartmentss Human 95% 0.06468 mg/L 0.07402 mg/L 0.873817887057552 -DTXSID2025135 Css 3compartmentss Human 95% 2.999 mg/L 3.014 mg/L 0.995023224950232 -DTXSID2025137 Css 3compartmentss Human 95% 2.57 mg/L 2.58 mg/L 0.996124031007752 -DTXSID2025139 Css 3compartmentss Human 95% 0.3375 mg/L 0.0003312 mg/L 1019.02173913043 -DTXSID2025183 Css 3compartmentss Human 95% 4.386 mg/L 2.438 mg/L 1.79901558654635 -DTXSID2025210 Css 3compartmentss Human 95% 35.18 mg/L 17.71 mg/L 1.98644833427442 -DTXSID2025216 Css 3compartmentss Human 95% 7.672 mg/L 7.282 mg/L 1.05355671518814 -DTXSID2025264 Css 3compartmentss Human 95% 0.1375 mg/L 0.05795 mg/L 2.37273511647972 -DTXSID2025345 Css 3compartmentss Human 95% 1.091 mg/L 0.8028 mg/L 1.35899352267065 -DTXSID2025347 Css 3compartmentss Human 95% 0.9632 mg/L 0.6182 mg/L 1.55807182141702 -DTXSID2025391 Css 3compartmentss Human 95% 0.206 mg/L 0.1629 mg/L 1.2645794966237 -DTXSID2025422 Css 3compartmentss Human 95% 3.828 mg/L 2.444 mg/L 1.56628477905074 -DTXSID2025474 Css 3compartmentss Human 95% 0.3033 mg/L 0 mg/L Inf -DTXSID2025501 Css 3compartmentss Human 95% 13.91 mg/L 12.89 mg/L 1.07913110938712 -DTXSID2025503 Css 3compartmentss Human 95% 5.655 mg/L 1.486 mg/L 3.80551816958277 -DTXSID2025505 Css 3compartmentss Human 95% 731.5 mg/L 3251 mg/L 0.225007689941556 -DTXSID2025632 Css 3compartmentss Human 95% 0.8921 mg/L 0.5807 mg/L 1.53624935422766 -DTXSID2025634 Css 3compartmentss Human 95% 1.244 mg/L 0.8278 mg/L 1.5027784489007 -DTXSID2025688 Css 3compartmentss Human 95% 2.197 mg/L 1.474 mg/L 1.49050203527815 -DTXSID2025715 Css 3compartmentss Human 95% 2.4 mg/L 1.847 mg/L 1.29940443963184 -DTXSID2025761 Css 3compartmentss Human 95% 9.893 mg/L 6.653 mg/L 1.48699834661055 -DTXSID2025763 Css 3compartmentss Human 95% 0.9622 mg/L 0.6041 mg/L 1.59278265187883 -DTXSID2025765 Css 3compartmentss Human 95% 1.456 mg/L 0.9837 mg/L 1.48012605469147 -DTXSID2025842 Css 3compartmentss Human 95% 3.833 mg/L 2.258 mg/L 1.69751992914083 -DTXSID2025892 Css 3compartmentss Human 95% 7.559 mg/L 0.6689 mg/L 11.3006428464643 -DTXSID2025896 Css 3compartmentss Human 95% 0.6111 mg/L 0.4721 mg/L 1.2944291463673 -DTXSID2025925 Css 3compartmentss Human 95% 0.06002 mg/L 0.03739 mg/L 1.60524204332709 -DTXSID2025977 Css 3compartmentss Human 95% 1.329 mg/L 1.365 mg/L 0.973626373626374 -DTXSID2026022 Css 3compartmentss Human 95% 11.47 mg/L 6.82 mg/L 1.68181818181818 -DTXSID2026074 Css 3compartmentss Human 95% 2.454 mg/L 0.245 mg/L 10.0163265306122 -DTXSID2026076 Css 3compartmentss Human 95% 5.585 mg/L 3.628 mg/L 1.53941565600882 -DTXSID2026101 Css 3compartmentss Human 95% 181.3 mg/L 72.75 mg/L 2.49209621993127 -DTXSID2026107 Css 3compartmentss Human 95% 1.81 mg/L 1.142 mg/L 1.58493870402802 -DTXSID2026151 Css 3compartmentss Human 95% 0.02785 mg/L 0 mg/L Inf -DTXSID2026157 Css 3compartmentss Human 95% 0.7422 mg/L 0.4312 mg/L 1.72124304267161 -DTXSID2026232 Css 3compartmentss Human 95% 4.089 mg/L 2.616 mg/L 1.56307339449541 -DTXSID2026444 Css 3compartmentss Human 95% 5.555 mg/L 3.733 mg/L 1.488079292794 -DTXSID2026446 Css 3compartmentss Human 95% 1.125 mg/L 0.2285 mg/L 4.92341356673961 -DTXSID2026448 Css 3compartmentss Human 95% 5.852 mg/L 3.911 mg/L 1.4962925083099 -DTXSID2026523 Css 3compartmentss Human 95% 8.499 mg/L 5.215 mg/L 1.62972195589645 -DTXSID2026525 Css 3compartmentss Human 95% 279.4 mg/L 110.8 mg/L 2.52166064981949 -DTXSID2026527 Css 3compartmentss Human 95% 3.586 mg/L 1.416 mg/L 2.53248587570621 -DTXSID2026529 Css 3compartmentss Human 95% 3.948 mg/L 1.662 mg/L 2.37545126353791 -DTXSID2026573 Css 3compartmentss Human 95% 2.085 mg/L 1.253 mg/L 1.66400638467678 -DTXSID2026600 Css 3compartmentss Human 95% 7.731 mg/L 4.647 mg/L 1.66365397030342 -DTXSID2026602 Css 3compartmentss Human 95% 140.5 mg/L 10.65 mg/L 13.1924882629108 -DTXSID2026606 Css 3compartmentss Human 95% 0.9101 mg/L 0.5743 mg/L 1.58471182308898 -DTXSID2026608 Css 3compartmentss Human 95% 8.335 mg/L 5.111 mg/L 1.63079632165917 -DTXSID2026739 Css 3compartmentss Human 95% 0.02981 mg/L 0.01794 mg/L 1.66164994425864 -DTXSID2026783 Css 3compartmentss Human 95% 5.613 mg/L 3.261 mg/L 1.721251149954 -DTXSID2026789 Css 3compartmentss Human 95% 6.141 mg/L 3.807 mg/L 1.61308116627266 -DTXSID2026943 Css 3compartmentss Human 95% 5.531 mg/L 3.307 mg/L 1.67251285152706 -DTXSID2026991 Css 3compartmentss Human 95% 0.02406 mg/L 0.01528 mg/L 1.57460732984293 -DTXSID2026997 Css 3compartmentss Human 95% 0.2081 mg/L 0.1225 mg/L 1.69877551020408 -DTXSID2027044 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID2027048 Css 3compartmentss Human 95% 8.649 mg/L 5.252 mg/L 1.6468012185834 -DTXSID2027092 Css 3compartmentss Human 95% 1.137 mg/L 0.7871 mg/L 1.44454326006861 -DTXSID2027094 Css 3compartmentss Human 95% 30.79 mg/L 0.004134 mg/L 7447.99225931301 -DTXSID2027096 Css 3compartmentss Human 95% 7.035 mg/L 4.698 mg/L 1.49744572158365 -DTXSID2027098 Css 3compartmentss Human 95% 6.461 mg/L 4.102 mg/L 1.57508532423208 -DTXSID2027175 Css 3compartmentss Human 95% 2.204 mg/L 1.856 mg/L 1.1875 -DTXSID2027204 Css 3compartmentss Human 95% 1.739 mg/L 1.2 mg/L 1.44916666666667 -DTXSID2027206 Css 3compartmentss Human 95% 5.565 mg/L 3.833 mg/L 1.45186537959823 -DTXSID2027333 Css 3compartmentss Human 95% 0.02311 mg/L 0.01513 mg/L 1.52742894910773 -DTXSID2027381 Css 3compartmentss Human 95% 2137 mg/L 9739 mg/L 0.219427045897936 -DTXSID2027412 Css 3compartmentss Human 95% 7.219 mg/L 4.753 mg/L 1.51883021249737 -DTXSID2027414 Css 3compartmentss Human 95% 6.958 mg/L 4.884 mg/L 1.42465192465192 -DTXSID2027418 Css 3compartmentss Human 95% 5.656 mg/L 3.407 mg/L 1.66011153507485 -DTXSID2027462 Css 3compartmentss Human 95% 74.8 mg/L 38.27 mg/L 1.95453357721453 -DTXSID2027466 Css 3compartmentss Human 95% 1.698 mg/L 1.107 mg/L 1.53387533875339 -DTXSID2027543 Css 3compartmentss Human 95% 3.1 mg/L 2.262 mg/L 1.37046861184792 -DTXSID2027591 Css 3compartmentss Human 95% 1.066 mg/L 0.6993 mg/L 1.52438152438152 -DTXSID2027595 Css 3compartmentss Human 95% 2.473 mg/L 1.571 mg/L 1.57415658816041 -DTXSID2027599 Css 3compartmentss Human 95% 8.057 mg/L 4.995 mg/L 1.61301301301301 -DTXSID2027620 Css 3compartmentss Human 95% 0.4793 mg/L 0.3168 mg/L 1.51294191919192 -DTXSID2027624 Css 3compartmentss Human 95% 3.127 mg/L 1.646 mg/L 1.89975698663426 -DTXSID2027759 Css 3compartmentss Human 95% 4.674 mg/L 2.269 mg/L 2.05993829881005 -DTXSID2027830 Css 3compartmentss Human 95% 1.582 mg/L 1.001 mg/L 1.58041958041958 -DTXSID2027834 Css 3compartmentss Human 95% 3.232 mg/L 1.879 mg/L 1.72006386375732 -DTXSID2027886 Css 3compartmentss Human 95% 30.12 mg/L 0.992 mg/L 30.3629032258065 -DTXSID2027963 Css 3compartmentss Human 95% 877.4 mg/L 4639 mg/L 0.189135589566717 -DTXSID2028010 Css 3compartmentss Human 95% 6.148 mg/L 3.761 mg/L 1.63467162988567 -DTXSID2028723 Css 3compartmentss Human 95% 32.01 mg/L 11.79 mg/L 2.71501272264631 -DTXSID2029117 Css 3compartmentss Human 95% 11.12 mg/L 0.007174 mg/L 1550.04181767494 -DTXSID2029167 Css 3compartmentss Human 95% 1.461 mg/L 0.9051 mg/L 1.61418627775936 -DTXSID2029169 Css 3compartmentss Human 95% 3313 mg/L 9659 mg/L 0.342996169375712 -DTXSID2029242 Css 3compartmentss Human 95% 0.09504 mg/L 0.05849 mg/L 1.6248931441272 -DTXSID2029246 Css 3compartmentss Human 95% 24.61 mg/L 0.7428 mg/L 33.131394722671 -DTXSID2029298 Css 3compartmentss Human 95% 77.3 mg/L 45.51 mg/L 1.69852779608877 -DTXSID2029325 Css 3compartmentss Human 95% 31.13 mg/L 39.99 mg/L 0.778444611152788 -DTXSID2029329 Css 3compartmentss Human 95% 0.9445 mg/L 0.592 mg/L 1.59543918918919 -DTXSID2029616 Css 3compartmentss Human 95% 3.463 mg/L 1.337 mg/L 2.59012715033657 -DTXSID2029662 Css 3compartmentss Human 95% 0.001078 mg/L 0 mg/L Inf -DTXSID2029668 Css 3compartmentss Human 95% 18.35 mg/L 27.08 mg/L 0.677621861152142 -DTXSID2029874 Css 3compartmentss Human 95% 0.8854 mg/L 0.08627 mg/L 10.26312739075 -DTXSID2030695 Css 3compartmentss Human 95% 12.16 mg/L 6.456 mg/L 1.88351920693928 -DTXSID2031374 Css 3compartmentss Human 95% 5.492 mg/L 4.163 mg/L 1.31924093202018 -DTXSID2031532 Css 3compartmentss Human 95% 1.719 mg/L 1.769 mg/L 0.971735443753533 -DTXSID2031956 Css 3compartmentss Human 95% 0.2955 mg/L 0.2152 mg/L 1.37314126394052 -DTXSID2032005 Css 3compartmentss Human 95% 135.1 mg/L 5.417 mg/L 24.9400036920805 -DTXSID2032180 Css 3compartmentss Human 95% 8615 mg/L 4596 mg/L 1.87445604873803 -DTXSID2032342 Css 3compartmentss Human 95% 25.22 mg/L 14.99 mg/L 1.68245496997999 -DTXSID2032344 Css 3compartmentss Human 95% 0.7969 mg/L 0.1224 mg/L 6.51062091503268 -DTXSID2032348 Css 3compartmentss Human 95% 13700 mg/L 7742 mg/L 1.76956858692844 -DTXSID2032390 Css 3compartmentss Human 95% 28.84 mg/L 15.69 mg/L 1.83811344805609 -DTXSID2032392 Css 3compartmentss Human 95% 916.9 mg/L 1297 mg/L 0.706939090208173 -DTXSID2032398 Css 3compartmentss Human 95% 23.79 mg/L 3.585 mg/L 6.63598326359833 -DTXSID2032421 Css 3compartmentss Human 95% 1234 mg/L 727.7 mg/L 1.695753744675 -DTXSID2032500 Css 3compartmentss Human 95% 18.41 mg/L 10.73 mg/L 1.71575023299161 -DTXSID2032502 Css 3compartmentss Human 95% 0.5771 mg/L 0.428 mg/L 1.34836448598131 -DTXSID2032550 Css 3compartmentss Human 95% 26 mg/L 2.3 mg/L 11.304347826087 -DTXSID2032552 Css 3compartmentss Human 95% 1.758 mg/L 1.111 mg/L 1.58235823582358 -DTXSID2032554 Css 3compartmentss Human 95% 0.9159 mg/L 0.1853 mg/L 4.94279546681058 -DTXSID2032558 Css 3compartmentss Human 95% 0.4208 mg/L 0.1769 mg/L 2.37874505370266 -DTXSID2032631 Css 3compartmentss Human 95% 3.948 mg/L 2.265 mg/L 1.74304635761589 -DTXSID2032637 Css 3compartmentss Human 95% 0.5496 mg/L 0.4165 mg/L 1.31956782713085 -DTXSID2032639 Css 3compartmentss Human 95% 38.17 mg/L 15.07 mg/L 2.53284671532847 -DTXSID2032683 Css 3compartmentss Human 95% 0.5151 mg/L 0.381 mg/L 1.35196850393701 -DTXSID2032891 Css 3compartmentss Human 95% 14.38 mg/L 10.84 mg/L 1.32656826568266 -DTXSID2033281 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID2033314 Css 3compartmentss Human 95% 0.4279 mg/L 0.2381 mg/L 1.79714405711886 -DTXSID2033445 Css 3compartmentss Human 95% 0.6469 mg/L 0.4463 mg/L 1.44947344835313 -DTXSID2033493 Css 3compartmentss Human 95% 1.692 mg/L 1.143 mg/L 1.48031496062992 -DTXSID2033736 Css 3compartmentss Human 95% 0.2926 mg/L 0.09947 mg/L 2.94159042927516 -DTXSID2034091 Css 3compartmentss Human 95% 6.738 mg/L 4.802 mg/L 1.40316534777176 -DTXSID2034095 Css 3compartmentss Human 95% 0.09649 mg/L 0.02735 mg/L 3.52797074954296 -DTXSID2034255 Css 3compartmentss Human 95% 6.413 mg/L 4.122 mg/L 1.55579815623484 -DTXSID2034259 Css 3compartmentss Human 95% 2.429 mg/L 0.9953 mg/L 2.44047020998694 -DTXSID2034338 Css 3compartmentss Human 95% 3.183 mg/L 1.825 mg/L 1.7441095890411 -DTXSID2034382 Css 3compartmentss Human 95% 6.853 mg/L 0.001251 mg/L 5478.01758593125 -DTXSID2034465 Css 3compartmentss Human 95% 0.6694 mg/L 0.4154 mg/L 1.61145883485797 -DTXSID2034540 Css 3compartmentss Human 95% 8.522 mg/L 5.487 mg/L 1.55312556952798 -DTXSID2034542 Css 3compartmentss Human 95% 0.9953 mg/L 0.5427 mg/L 1.83397825686383 -DTXSID2034590 Css 3compartmentss Human 95% 13.52 mg/L 5.942 mg/L 2.27532817233255 -DTXSID2034598 Css 3compartmentss Human 95% 0.7601 mg/L 0.1189 mg/L 6.39276703111859 -DTXSID2034625 Css 3compartmentss Human 95% 10.98 mg/L 3.44 mg/L 3.19186046511628 -DTXSID2034627 Css 3compartmentss Human 95% 16.35 mg/L 9.159 mg/L 1.78512938093678 -DTXSID2034673 Css 3compartmentss Human 95% 146 mg/L 77.71 mg/L 1.87878007978381 -DTXSID2034700 Css 3compartmentss Human 95% 33.47 mg/L 18.59 mg/L 1.80043033889188 -DTXSID2034833 Css 3compartmentss Human 95% 104.7 mg/L 57.78 mg/L 1.81204569055036 -DTXSID2034881 Css 3compartmentss Human 95% 872.6 mg/L 1662 mg/L 0.52503008423586 -DTXSID2034885 Css 3compartmentss Human 95% 7.172 mg/L 0.2235 mg/L 32.089485458613 -DTXSID2034962 Css 3compartmentss Human 95% 5.736 mg/L 3.645 mg/L 1.57366255144033 -DTXSID2034968 Css 3compartmentss Human 95% 2.127 mg/L 1.346 mg/L 1.58023774145617 -DTXSID2035013 Css 3compartmentss Human 95% 5.679 mg/L 4.995 mg/L 1.13693693693694 -DTXSID2035481 Css 3compartmentss Human 95% 1.27 mg/L 1.027 mg/L 1.23661148977605 -DTXSID2036112 Css 3compartmentss Human 95% 1.431 mg/L 0.01257 mg/L 113.842482100239 -DTXSID2036409 Css 3compartmentss Human 95% 5.506 mg/L 2.503 mg/L 2.19976028765481 -DTXSID2036588 Css 3compartmentss Human 95% 2625 mg/L 5059 mg/L 0.518877248468077 -DTXSID2036827 Css 3compartmentss Human 95% 9.947 mg/L 7.534 mg/L 1.32028139102734 -DTXSID2037186 Css 3compartmentss Human 95% 9.774 mg/L 4.409 mg/L 2.21682921297346 -DTXSID2037502 Css 3compartmentss Human 95% 8.421 mg/L 1.95 mg/L 4.31846153846154 -DTXSID2037712 Css 3compartmentss Human 95% 7.154 mg/L 2.992 mg/L 2.39104278074866 -DTXSID2037714 Css 3compartmentss Human 95% 12.9 mg/L 3.509 mg/L 3.6762610430322 -DTXSID2038732 Css 3compartmentss Human 95% 0.1454 mg/L 0.1074 mg/L 1.35381750465549 -DTXSID2038788 Css 3compartmentss Human 95% 6.916 mg/L 4.202 mg/L 1.64588291289862 -DTXSID2038813 Css 3compartmentss Human 95% 0.7933 mg/L 0.5483 mg/L 1.44683567390115 -DTXSID2039336 Css 3compartmentss Human 95% 48.01 mg/L 8.658 mg/L 5.54516054516055 -DTXSID2040151 Css 3compartmentss Human 95% 0.2338 mg/L 0.2127 mg/L 1.09920075223319 -DTXSID2040234 Css 3compartmentss Human 95% 2.919 mg/L 1.593 mg/L 1.83239171374765 -DTXSID2040236 Css 3compartmentss Human 95% 1.845 mg/L 1.108 mg/L 1.66516245487365 -DTXSID2040284 Css 3compartmentss Human 95% 35.32 mg/L 19.05 mg/L 1.85406824146982 -DTXSID2040361 Css 3compartmentss Human 95% 1.461 mg/L 0.9051 mg/L 1.61418627775936 -DTXSID2040363 Css 3compartmentss Human 95% 342.3 mg/L 204.4 mg/L 1.67465753424658 -DTXSID2040525 Css 3compartmentss Human 95% 18.13 mg/L 8.984 mg/L 2.0180320569902 -DTXSID2040579 Css 3compartmentss Human 95% 4.437 mg/L 4.488 mg/L 0.988636363636364 -DTXSID2040608 Css 3compartmentss Human 95% 0.2119 mg/L 0.1456 mg/L 1.45535714285714 -DTXSID2040652 Css 3compartmentss Human 95% 1.122 mg/L 0.9573 mg/L 1.172046380445 -DTXSID2040656 Css 3compartmentss Human 95% 5.36 mg/L 3.711 mg/L 1.44435462139585 -DTXSID2040731 Css 3compartmentss Human 95% 1.324 mg/L 0.6728 mg/L 1.9678953626635 -DTXSID2040733 Css 3compartmentss Human 95% 90.52 mg/L 0.000269 mg/L 336505.576208178 -DTXSID2040735 Css 3compartmentss Human 95% 9.273 mg/L 6.672 mg/L 1.3898381294964 -DTXSID2040739 Css 3compartmentss Human 95% 5.668 mg/L 3.628 mg/L 1.56229327453142 -DTXSID2040783 Css 3compartmentss Human 95% 4.442 mg/L 0.2546 mg/L 17.4469756480754 -DTXSID2040787 Css 3compartmentss Human 95% 0.4261 mg/L 0.005616 mg/L 75.8725071225071 -DTXSID2040945 Css 3compartmentss Human 95% 0.3097 mg/L 0.1534 mg/L 2.01890482398957 -DTXSID2041046 Css 3compartmentss Human 95% 1.572 mg/L 1.123 mg/L 1.39982190560997 -DTXSID2041125 Css 3compartmentss Human 95% 7.85 mg/L 4.905 mg/L 1.60040774719674 -DTXSID2041200 Css 3compartmentss Human 95% 1.686 mg/L 0.9304 mg/L 1.81212381771281 -DTXSID2041208 Css 3compartmentss Human 95% 13.96 mg/L 9.082 mg/L 1.53710636423695 -DTXSID2041250 Css 3compartmentss Human 95% 504.1 mg/L 296 mg/L 1.70304054054054 -DTXSID2041252 Css 3compartmentss Human 95% 19.65 mg/L 14.64 mg/L 1.3422131147541 -DTXSID2041256 Css 3compartmentss Human 95% 3.367 mg/L 1.98 mg/L 1.70050505050505 -DTXSID2041389 Css 3compartmentss Human 95% 4.94 mg/L 3.361 mg/L 1.46980065456709 -DTXSID2041412 Css 3compartmentss Human 95% 5.558 mg/L 3.776 mg/L 1.47192796610169 -DTXSID2041416 Css 3compartmentss Human 95% 7.176 mg/L 6.034 mg/L 1.18926085515413 -DTXSID2041418 Css 3compartmentss Human 95% 8.138 mg/L 5.272 mg/L 1.54362670713202 -DTXSID2041460 Css 3compartmentss Human 95% 29.24 mg/L 16.27 mg/L 1.79717271051014 -DTXSID2041464 Css 3compartmentss Human 95% 1.402 mg/L 0.8634 mg/L 1.62381283298587 -DTXSID2041468 Css 3compartmentss Human 95% 22.52 mg/L 19.48 mg/L 1.15605749486653 -DTXSID2041545 Css 3compartmentss Human 95% 13.77 mg/L 7.852 mg/L 1.75369332654101 -DTXSID2041547 Css 3compartmentss Human 95% 6.184 mg/L 2.507 mg/L 2.46669325887515 -DTXSID2041622 Css 3compartmentss Human 95% 0.486 mg/L 0.09283 mg/L 5.23537649466767 -DTXSID2041672 Css 3compartmentss Human 95% 0.145 mg/L 0.09327 mg/L 1.55462635359708 -DTXSID2041703 Css 3compartmentss Human 95% 40.25 mg/L 21.49 mg/L 1.87296416938111 -DTXSID2041709 Css 3compartmentss Human 95% 8.689 mg/L 4.517 mg/L 1.92362187292451 -DTXSID2041759 Css 3compartmentss Human 95% 0.03419 mg/L 0.0002832 mg/L 120.727401129944 -DTXSID2041880 Css 3compartmentss Human 95% 0.006537 mg/L 0.003834 mg/L 1.70500782472613 -DTXSID2041884 Css 3compartmentss Human 95% 0.237 mg/L 0.04454 mg/L 5.32105972159856 -DTXSID2041886 Css 3compartmentss Human 95% 0.02265 mg/L 0.01352 mg/L 1.67529585798817 -DTXSID2041913 Css 3compartmentss Human 95% 6.362 mg/L 2.816 mg/L 2.25923295454545 -DTXSID2041917 Css 3compartmentss Human 95% 3.659 mg/L 2.502 mg/L 1.46243005595524 -DTXSID2042014 Css 3compartmentss Human 95% 6.109 mg/L 3.838 mg/L 1.59171443460135 -DTXSID2042060 Css 3compartmentss Human 95% 27.38 mg/L 45.27 mg/L 0.604815551137619 -DTXSID2042143 Css 3compartmentss Human 95% 0.871 mg/L 0.5125 mg/L 1.69951219512195 -DTXSID2042145 Css 3compartmentss Human 95% 2.727 mg/L 1.737 mg/L 1.5699481865285 -DTXSID2042149 Css 3compartmentss Human 95% 0.3483 mg/L 0.2466 mg/L 1.41240875912409 -DTXSID2042191 Css 3compartmentss Human 95% 1.226 mg/L 0.7684 mg/L 1.59552316501822 -DTXSID2042195 Css 3compartmentss Human 95% 20.77 mg/L 11.25 mg/L 1.84622222222222 -DTXSID2042199 Css 3compartmentss Human 95% 4.063 mg/L 2.454 mg/L 1.65566422167889 -DTXSID2042220 Css 3compartmentss Human 95% 3.945 mg/L 1.76 mg/L 2.24147727272727 -DTXSID2042224 Css 3compartmentss Human 95% 9.048 mg/L 3.858 mg/L 2.3452566096423 -DTXSID2042276 Css 3compartmentss Human 95% 1.071 mg/L 0.7111 mg/L 1.50611728308255 -DTXSID2042436 Css 3compartmentss Human 95% 134.3 mg/L 75.21 mg/L 1.78566679962771 -DTXSID2042517 Css 3compartmentss Human 95% 9.866 mg/L 5.849 mg/L 1.68678406565225 -DTXSID2043747 Css 3compartmentss Human 95% 1.112 mg/L 0.04815 mg/L 23.0944963655244 -DTXSID2043874 Css 3compartmentss Human 95% 0.2873 mg/L 0.1075 mg/L 2.67255813953488 -DTXSID2043903 Css 3compartmentss Human 95% 11.18 mg/L 7.126 mg/L 1.56890261015998 -DTXSID2043909 Css 3compartmentss Human 95% 1.133 mg/L 0.6847 mg/L 1.65473930188404 -DTXSID2044000 Css 3compartmentss Human 95% 1.524 mg/L 0.04892 mg/L 31.1529026982829 -DTXSID2044002 Css 3compartmentss Human 95% 0.1662 mg/L 0.1055 mg/L 1.57535545023697 -DTXSID2044131 Css 3compartmentss Human 95% 23.21 mg/L 11.88 mg/L 1.9537037037037 -DTXSID2044137 Css 3compartmentss Human 95% 0.3714 mg/L 0.2273 mg/L 1.63396392432908 -DTXSID2044210 Css 3compartmentss Human 95% 2.671 mg/L 1.685 mg/L 1.58516320474777 -DTXSID2044214 Css 3compartmentss Human 95% 5.226 mg/L 4.365 mg/L 1.19725085910653 -DTXSID2044218 Css 3compartmentss Human 95% 6.71 mg/L 0.5025 mg/L 13.3532338308458 -DTXSID2044266 Css 3compartmentss Human 95% 0.3702 mg/L 0.06313 mg/L 5.86408997307144 -DTXSID2044268 Css 3compartmentss Human 95% 2.864 mg/L 1.516 mg/L 1.88918205804749 -DTXSID2044347 Css 3compartmentss Human 95% 0.2358 mg/L 0.1464 mg/L 1.61065573770492 -DTXSID2044391 Css 3compartmentss Human 95% 2.669 mg/L 2.537 mg/L 1.0520299566417 -DTXSID2044393 Css 3compartmentss Human 95% 5.351 mg/L 4.027 mg/L 1.32878073007201 -DTXSID2044397 Css 3compartmentss Human 95% 8.051 mg/L 5.12 mg/L 1.5724609375 -DTXSID2044399 Css 3compartmentss Human 95% 7.635 mg/L 4.689 mg/L 1.62827895073576 -DTXSID2044420 Css 3compartmentss Human 95% 42.39 mg/L 26.57 mg/L 1.59540835528792 -DTXSID2044422 Css 3compartmentss Human 95% 0.01106 mg/L 0.00922 mg/L 1.19956616052061 -DTXSID2044424 Css 3compartmentss Human 95% 2.199 mg/L 1.528 mg/L 1.43913612565445 -DTXSID2044428 Css 3compartmentss Human 95% 0.2478 mg/L 0.1631 mg/L 1.51931330472103 -DTXSID2044470 Css 3compartmentss Human 95% 1.737 mg/L 1.34 mg/L 1.29626865671642 -DTXSID2044472 Css 3compartmentss Human 95% 5.512 mg/L 3.797 mg/L 1.45167237292599 -DTXSID2044474 Css 3compartmentss Human 95% 3.036 mg/L 2.24 mg/L 1.35535714285714 -DTXSID2044503 Css 3compartmentss Human 95% 551.5 mg/L 403.9 mg/L 1.3654369893538 -DTXSID2044507 Css 3compartmentss Human 95% 1.537 mg/L 0.1934 mg/L 7.94725956566701 -DTXSID2044509 Css 3compartmentss Human 95% 504 mg/L 288.3 mg/L 1.74817898022893 -DTXSID2044553 Css 3compartmentss Human 95% 7.87 mg/L 4.71 mg/L 1.67091295116773 -DTXSID2044559 Css 3compartmentss Human 95% 16.88 mg/L 0.05759 mg/L 293.106442090641 -DTXSID2044632 Css 3compartmentss Human 95% 2.275 mg/L 1.069 mg/L 2.12815715622077 -DTXSID2044638 Css 3compartmentss Human 95% 0.5737 mg/L 0.3294 mg/L 1.74165148755313 -DTXSID2044680 Css 3compartmentss Human 95% 3.151 mg/L 2.173 mg/L 1.45006902899218 -DTXSID2044682 Css 3compartmentss Human 95% 3.507 mg/L 2.581 mg/L 1.3587756683456 -DTXSID2044684 Css 3compartmentss Human 95% 10.89 mg/L 6.713 mg/L 1.62222553254879 -DTXSID2044686 Css 3compartmentss Human 95% 1.181 mg/L 0.6651 mg/L 1.77567283115321 -DTXSID2044713 Css 3compartmentss Human 95% 963.6 mg/L 562.9 mg/L 1.71184935157222 -DTXSID2044715 Css 3compartmentss Human 95% 0.8902 mg/L 0.7144 mg/L 1.24608062709966 -DTXSID2044717 Css 3compartmentss Human 95% 50.38 mg/L 9.255 mg/L 5.44354403025392 -DTXSID2044719 Css 3compartmentss Human 95% 3.097 mg/L 0.5746 mg/L 5.38983640793596 -DTXSID2044763 Css 3compartmentss Human 95% 0.6357 mg/L 0.3855 mg/L 1.64902723735409 -DTXSID2044767 Css 3compartmentss Human 95% 1.132 mg/L 0.4727 mg/L 2.39475354347366 -DTXSID2044840 Css 3compartmentss Human 95% 7.136 mg/L 4.213 mg/L 1.69380488962734 -DTXSID2044842 Css 3compartmentss Human 95% 0.007238 mg/L 0.0001153 mg/L 62.7753686036427 -DTXSID2044844 Css 3compartmentss Human 95% 0.1217 mg/L 0.0489 mg/L 2.48875255623722 -DTXSID2044846 Css 3compartmentss Human 95% 1.126 mg/L 0.6848 mg/L 1.64427570093458 -DTXSID2044848 Css 3compartmentss Human 95% 1.578 mg/L 1.009 mg/L 1.56392467789891 -DTXSID2044890 Css 3compartmentss Human 95% 1.812 mg/L 0.8191 mg/L 2.21218410450494 -DTXSID2044892 Css 3compartmentss Human 95% 4.272 mg/L 2.045 mg/L 2.08899755501223 -DTXSID2044894 Css 3compartmentss Human 95% 1.803 mg/L 1.142 mg/L 1.57880910683012 -DTXSID2044896 Css 3compartmentss Human 95% 1.532 mg/L 0.8 mg/L 1.915 -DTXSID2044898 Css 3compartmentss Human 95% 0.5034 mg/L 0.3254 mg/L 1.54701905347265 -DTXSID2044925 Css 3compartmentss Human 95% 114.8 mg/L 53.4 mg/L 2.1498127340824 -DTXSID2044927 Css 3compartmentss Human 95% 7.676 mg/L 0.5654 mg/L 13.5762292182526 -DTXSID2044971 Css 3compartmentss Human 95% 8.547 mg/L 1.776 mg/L 4.8125 -DTXSID2044975 Css 3compartmentss Human 95% 0.1538 mg/L 0.1132 mg/L 1.35865724381625 -DTXSID2044979 Css 3compartmentss Human 95% 4.886 mg/L 2.993 mg/L 1.63247577681256 -DTXSID2045072 Css 3compartmentss Human 95% 253.4 mg/L 147.8 mg/L 1.71447902571042 -DTXSID2045076 Css 3compartmentss Human 95% 10.72 mg/L 6.491 mg/L 1.6515174857495 -DTXSID2045078 Css 3compartmentss Human 95% 6.861 mg/L 4.32 mg/L 1.58819444444444 -DTXSID2045101 Css 3compartmentss Human 95% 7.316 mg/L 4.942 mg/L 1.48037231889923 -DTXSID2045103 Css 3compartmentss Human 95% 0.2362 mg/L 0.1888 mg/L 1.2510593220339 -DTXSID2045105 Css 3compartmentss Human 95% 2.395 mg/L 0.1138 mg/L 21.0456942003515 -DTXSID2045107 Css 3compartmentss Human 95% 8.681 mg/L 5.408 mg/L 1.60521449704142 -DTXSID2045109 Css 3compartmentss Human 95% 0.7452 mg/L 0.04218 mg/L 17.6671408250356 -DTXSID2045151 Css 3compartmentss Human 95% 3.069 mg/L 2.366 mg/L 1.2971259509721 -DTXSID2045153 Css 3compartmentss Human 95% 1.923 mg/L 1.184 mg/L 1.62415540540541 -DTXSID2045157 Css 3compartmentss Human 95% 0.04727 mg/L 0.02836 mg/L 1.66678420310296 -DTXSID2045232 Css 3compartmentss Human 95% 33.29 mg/L 6.811 mg/L 4.88768169138159 -DTXSID2045236 Css 3compartmentss Human 95% 17.31 mg/L 10.38 mg/L 1.66763005780347 -DTXSID2045238 Css 3compartmentss Human 95% 1.028 mg/L 0.6252 mg/L 1.64427383237364 -DTXSID2045280 Css 3compartmentss Human 95% 0.1933 mg/L 0.1037 mg/L 1.86403085824494 -DTXSID2045315 Css 3compartmentss Human 95% 28.43 mg/L 2.246 mg/L 12.6580587711487 -DTXSID2045361 Css 3compartmentss Human 95% 4.476 mg/L 3.197 mg/L 1.40006255864873 -DTXSID2045365 Css 3compartmentss Human 95% 9.338 mg/L 5.252 mg/L 1.77798933739528 -DTXSID2045367 Css 3compartmentss Human 95% 13.79 mg/L 1.428 mg/L 9.65686274509804 -DTXSID2045440 Css 3compartmentss Human 95% 8.557e-05 mg/L 0 mg/L Inf -DTXSID2045442 Css 3compartmentss Human 95% 1.476 mg/L 0.952 mg/L 1.55042016806723 -DTXSID2045444 Css 3compartmentss Human 95% 0.464 mg/L 0.3198 mg/L 1.45090681676048 -DTXSID2045448 Css 3compartmentss Human 95% 4.384 mg/L 1.751 mg/L 2.50371216447744 -DTXSID2045490 Css 3compartmentss Human 95% 30.31 mg/L 5.643 mg/L 5.371256423888 -DTXSID2045492 Css 3compartmentss Human 95% 8.869 mg/L 5.528 mg/L 1.60437771345876 -DTXSID2045494 Css 3compartmentss Human 95% 0.445 mg/L 0.1977 mg/L 2.250885179565 -DTXSID2045496 Css 3compartmentss Human 95% 1.927 mg/L 0.03527 mg/L 54.6356677062659 -DTXSID2045498 Css 3compartmentss Human 95% 2.049 mg/L 1.235 mg/L 1.65910931174089 -DTXSID2045521 Css 3compartmentss Human 95% 3.453 mg/L 2.252 mg/L 1.53330373001776 -DTXSID2045523 Css 3compartmentss Human 95% 5.532 mg/L 3.307 mg/L 1.67281524039915 -DTXSID2045527 Css 3compartmentss Human 95% 1.217 mg/L 0.7465 mg/L 1.63027461486939 -DTXSID2045529 Css 3compartmentss Human 95% 15.69 mg/L 1.04 mg/L 15.0865384615385 -DTXSID2045571 Css 3compartmentss Human 95% 5.299 mg/L 4.162 mg/L 1.27318596828448 -DTXSID2045573 Css 3compartmentss Human 95% 32.36 mg/L 18.48 mg/L 1.75108225108225 -DTXSID2045575 Css 3compartmentss Human 95% 0.3662 mg/L 0.2751 mg/L 1.33115230825154 -DTXSID2045579 Css 3compartmentss Human 95% 17.64 mg/L 11.75 mg/L 1.50127659574468 -DTXSID2045600 Css 3compartmentss Human 95% 8.264 mg/L 5.308 mg/L 1.55689525244913 -DTXSID2045602 Css 3compartmentss Human 95% 42.71 mg/L 28 mg/L 1.52535714285714 -DTXSID2045604 Css 3compartmentss Human 95% 94.58 mg/L 54.24 mg/L 1.74373156342183 -DTXSID2045606 Css 3compartmentss Human 95% 0.1514 mg/L 0.1093 mg/L 1.38517840805124 -DTXSID2045608 Css 3compartmentss Human 95% 0.8378 mg/L 0.5615 mg/L 1.49207479964381 -DTXSID2045650 Css 3compartmentss Human 95% 6.073 mg/L 3.843 mg/L 1.58027582617747 -DTXSID2045652 Css 3compartmentss Human 95% 0.515 mg/L 0.3643 mg/L 1.41367005215482 -DTXSID2045654 Css 3compartmentss Human 95% 6.963 mg/L 4.514 mg/L 1.5425343376163 -DTXSID2045656 Css 3compartmentss Human 95% 0.7319 mg/L 0.2366 mg/L 3.09340659340659 -DTXSID2045658 Css 3compartmentss Human 95% 1.602 mg/L 1.098 mg/L 1.45901639344262 -DTXSID2045735 Css 3compartmentss Human 95% 21.9 mg/L 12.11 mg/L 1.80842279108175 -DTXSID2045781 Css 3compartmentss Human 95% 1.035 mg/L 0.01554 mg/L 66.6023166023166 -DTXSID2045783 Css 3compartmentss Human 95% 0.05451 mg/L 0.04233 mg/L 1.28773919206237 -DTXSID2045785 Css 3compartmentss Human 95% 5.764 mg/L 1.636 mg/L 3.52322738386308 -DTXSID2045787 Css 3compartmentss Human 95% 5.223 mg/L 3.355 mg/L 1.55678092399404 -DTXSID2045789 Css 3compartmentss Human 95% 4.355 mg/L 3.073 mg/L 1.41718190693134 -DTXSID2045810 Css 3compartmentss Human 95% 5.327 mg/L 0.8227 mg/L 6.47502127142336 -DTXSID2045812 Css 3compartmentss Human 95% 0.4147 mg/L 0.2776 mg/L 1.49387608069164 -DTXSID2045814 Css 3compartmentss Human 95% 0.3359 mg/L 0.1832 mg/L 1.83351528384279 -DTXSID2045860 Css 3compartmentss Human 95% 0.2082 mg/L 0.001761 mg/L 118.228279386712 -DTXSID2045862 Css 3compartmentss Human 95% 0.3035 mg/L 0.2039 mg/L 1.48847474252084 -DTXSID2045864 Css 3compartmentss Human 95% 0.8173 mg/L 0.463 mg/L 1.76522678185745 -DTXSID2045868 Css 3compartmentss Human 95% 4.813 mg/L 3.989 mg/L 1.20656806217097 -DTXSID2045941 Css 3compartmentss Human 95% 10.82 mg/L 6.077 mg/L 1.78048379134441 -DTXSID2045943 Css 3compartmentss Human 95% 12.02 mg/L 2.347 mg/L 5.12143161482744 -DTXSID2045945 Css 3compartmentss Human 95% 2.715 mg/L 0.3315 mg/L 8.19004524886878 -DTXSID2045993 Css 3compartmentss Human 95% 4.607 mg/L 3.21 mg/L 1.43520249221184 -DTXSID2046042 Css 3compartmentss Human 95% 6.488 mg/L 0.056 mg/L 115.857142857143 -DTXSID2046090 Css 3compartmentss Human 95% 0.2224 mg/L 0.1617 mg/L 1.37538651824366 -DTXSID2046092 Css 3compartmentss Human 95% 13.77 mg/L 7.448 mg/L 1.84881847475832 -DTXSID2046094 Css 3compartmentss Human 95% 2.947 mg/L 2.664 mg/L 1.10623123123123 -DTXSID2046096 Css 3compartmentss Human 95% 0.1642 mg/L 0.1353 mg/L 1.21359940872136 -DTXSID2046121 Css 3compartmentss Human 95% 1018 mg/L 588.9 mg/L 1.72864662930888 -DTXSID2046123 Css 3compartmentss Human 95% 3.519 mg/L 1.591 mg/L 2.21181646763042 -DTXSID2046127 Css 3compartmentss Human 95% 5.344 mg/L 2.35 mg/L 2.27404255319149 -DTXSID2046171 Css 3compartmentss Human 95% 5.534 mg/L 3.307 mg/L 1.67342001814333 -DTXSID2046173 Css 3compartmentss Human 95% 2.798 mg/L 1.988 mg/L 1.40744466800805 -DTXSID2046175 Css 3compartmentss Human 95% 10.42 mg/L 0.3788 mg/L 27.5079197465681 -DTXSID2046177 Css 3compartmentss Human 95% 35.4 mg/L 0.4972 mg/L 71.1987127916331 -DTXSID2046179 Css 3compartmentss Human 95% 11.65 mg/L 6.412 mg/L 1.81690580162196 -DTXSID2046200 Css 3compartmentss Human 95% 0.1572 mg/L 0.0982 mg/L 1.60081466395112 -DTXSID2046202 Css 3compartmentss Human 95% 7.839 mg/L 4.965 mg/L 1.57885196374622 -DTXSID2046206 Css 3compartmentss Human 95% 11.45 mg/L 4.446 mg/L 2.57534862798021 -DTXSID2046208 Css 3compartmentss Human 95% 27.48 mg/L 15.57 mg/L 1.76493256262042 -DTXSID2046250 Css 3compartmentss Human 95% 11.23 mg/L 3.914 mg/L 2.86918753193664 -DTXSID2046252 Css 3compartmentss Human 95% 6.54 mg/L 4.243 mg/L 1.5413622436955 -DTXSID2046256 Css 3compartmentss Human 95% 1.228 mg/L 0.7947 mg/L 1.54523719642632 -DTXSID2046258 Css 3compartmentss Human 95% 1.671 mg/L 0.7845 mg/L 2.13001912045889 -DTXSID2046383 Css 3compartmentss Human 95% 0.1494 mg/L 0.08667 mg/L 1.72377985462098 -DTXSID2046385 Css 3compartmentss Human 95% 0.1494 mg/L 0.09461 mg/L 1.57911425853504 -DTXSID2046389 Css 3compartmentss Human 95% 7.43 mg/L 4.665 mg/L 1.59271168274384 -DTXSID2046410 Css 3compartmentss Human 95% 6.555 mg/L 4.101 mg/L 1.59839063643014 -DTXSID2046412 Css 3compartmentss Human 95% 5.58 mg/L 3.628 mg/L 1.5380374862183 -DTXSID2046418 Css 3compartmentss Human 95% 5.368 mg/L 3.628 mg/L 1.47960308710033 -DTXSID2046460 Css 3compartmentss Human 95% 20.15 mg/L 12.8 mg/L 1.57421875 -DTXSID2046462 Css 3compartmentss Human 95% 5.102 mg/L 3.311 mg/L 1.54092419208698 -DTXSID2046464 Css 3compartmentss Human 95% 2.029 mg/L 1.346 mg/L 1.5074294205052 -DTXSID2046468 Css 3compartmentss Human 95% 3.263 mg/L 1.88 mg/L 1.73563829787234 -DTXSID2046541 Css 3compartmentss Human 95% 0.3371 mg/L 0.2268 mg/L 1.4863315696649 -DTXSID2046543 Css 3compartmentss Human 95% 5.997 mg/L 3.571 mg/L 1.67936152338281 -DTXSID2046549 Css 3compartmentss Human 95% 8.424 mg/L 5.641 mg/L 1.49335224251019 -DTXSID2046591 Css 3compartmentss Human 95% 9.48 mg/L 0.4513 mg/L 21.0059827165965 -DTXSID2046593 Css 3compartmentss Human 95% 0.001704 mg/L 0 mg/L Inf -DTXSID2046597 Css 3compartmentss Human 95% 8.135 mg/L 5.16 mg/L 1.5765503875969 -DTXSID2046599 Css 3compartmentss Human 95% 1.723 mg/L 1.027 mg/L 1.67770204479065 -DTXSID2046624 Css 3compartmentss Human 95% 0.2358 mg/L 0.1158 mg/L 2.03626943005181 -DTXSID2046626 Css 3compartmentss Human 95% 5.571 mg/L 3.421 mg/L 1.62847120724934 -DTXSID2046628 Css 3compartmentss Human 95% 0.3244 mg/L 0.2157 mg/L 1.50394065832174 -DTXSID2046670 Css 3compartmentss Human 95% 0.1618 mg/L 0.1143 mg/L 1.41557305336833 -DTXSID2046674 Css 3compartmentss Human 95% 1.258 mg/L 0.5805 mg/L 2.16709732988803 -DTXSID2046678 Css 3compartmentss Human 95% 5.23 mg/L 3.414 mg/L 1.5319273579379 -DTXSID2046701 Css 3compartmentss Human 95% 0.1099 mg/L 0.01839 mg/L 5.97607395323545 -DTXSID2046703 Css 3compartmentss Human 95% 0.03754 mg/L 0 mg/L Inf -DTXSID2046705 Css 3compartmentss Human 95% 163.8 mg/L 84.36 mg/L 1.94167852062589 -DTXSID2046707 Css 3compartmentss Human 95% 5.038 mg/L 2.481 mg/L 2.03063280935107 -DTXSID2046709 Css 3compartmentss Human 95% 0.228 mg/L 0.1303 mg/L 1.74980813507291 -DTXSID2046751 Css 3compartmentss Human 95% 0.3329 mg/L 0.1017 mg/L 3.27335299901672 -DTXSID2046755 Css 3compartmentss Human 95% 3.9 mg/L 2.013 mg/L 1.93740685543964 -DTXSID2046759 Css 3compartmentss Human 95% 0.5923 mg/L 0.3602 mg/L 1.64436424208773 -DTXSID2046830 Css 3compartmentss Human 95% 0.5273 mg/L 0.3543 mg/L 1.48828676263054 -DTXSID2046832 Css 3compartmentss Human 95% 1.898 mg/L 0.7915 mg/L 2.39797852179406 -DTXSID2046834 Css 3compartmentss Human 95% 0.5626 mg/L 4e-09 mg/L 140650000 -DTXSID2046836 Css 3compartmentss Human 95% 0.2107 mg/L 0.1716 mg/L 1.22785547785548 -DTXSID2046880 Css 3compartmentss Human 95% 0.6325 mg/L 0.346 mg/L 1.82803468208092 -DTXSID2046882 Css 3compartmentss Human 95% 5.532 mg/L 3.307 mg/L 1.67281524039915 -DTXSID2046886 Css 3compartmentss Human 95% 19.52 mg/L 1.72 mg/L 11.3488372093023 -DTXSID2046888 Css 3compartmentss Human 95% 136 mg/L 157.6 mg/L 0.862944162436548 -DTXSID2046911 Css 3compartmentss Human 95% 0.5509 mg/L 0.374 mg/L 1.47299465240642 -DTXSID2046913 Css 3compartmentss Human 95% 2.45 mg/L 1.397 mg/L 1.75375805297065 -DTXSID2046915 Css 3compartmentss Human 95% 8.535 mg/L 5.107 mg/L 1.67123555903662 -DTXSID2047060 Css 3compartmentss Human 95% 0.0577 mg/L 0.03978 mg/L 1.45047762694822 -DTXSID2047062 Css 3compartmentss Human 95% 3.288 mg/L 2.17 mg/L 1.51520737327189 -DTXSID2047064 Css 3compartmentss Human 95% 27.67 mg/L 16.05 mg/L 1.72398753894081 -DTXSID2047066 Css 3compartmentss Human 95% 4.844 mg/L 2.269 mg/L 2.13486117232261 -DTXSID2047145 Css 3compartmentss Human 95% 7.83 mg/L 4.847 mg/L 1.61543222611925 -DTXSID2047149 Css 3compartmentss Human 95% 5.056 mg/L 5.742 mg/L 0.88052943225357 -DTXSID2047191 Css 3compartmentss Human 95% 18.17 mg/L 0.3192 mg/L 56.9235588972431 -DTXSID2047193 Css 3compartmentss Human 95% 5.43 mg/L 3.943 mg/L 1.37712401724575 -DTXSID2047195 Css 3compartmentss Human 95% 14.61 mg/L 19.69 mg/L 0.742001015744032 -DTXSID2047199 Css 3compartmentss Human 95% 2.471 mg/L 1.285 mg/L 1.92295719844358 -DTXSID2047222 Css 3compartmentss Human 95% 27.93 mg/L 0.009446 mg/L 2956.80711412238 -DTXSID2047270 Css 3compartmentss Human 95% 14.43 mg/L 3.953 mg/L 3.65039210726031 -DTXSID2047272 Css 3compartmentss Human 95% 15.7 mg/L 7.542 mg/L 2.0816759480244 -DTXSID2047274 Css 3compartmentss Human 95% 32.47 mg/L 20 mg/L 1.6235 -DTXSID2047276 Css 3compartmentss Human 95% 0.04037 mg/L 0.02881 mg/L 1.40124956612287 -DTXSID2047278 Css 3compartmentss Human 95% 6.363 mg/L 2.692 mg/L 2.36367013372957 -DTXSID2047301 Css 3compartmentss Human 95% 20.22 mg/L 10.12 mg/L 1.99802371541502 -DTXSID2047303 Css 3compartmentss Human 95% 27.16 mg/L 13.02 mg/L 2.08602150537634 -DTXSID2047305 Css 3compartmentss Human 95% 4.485 mg/L 2.482 mg/L 1.80701047542305 -DTXSID2047307 Css 3compartmentss Human 95% 122.3 mg/L 14.03 mg/L 8.71703492516037 -DTXSID2047309 Css 3compartmentss Human 95% 559.9 mg/L 398.8 mg/L 1.40396188565697 -DTXSID2047351 Css 3compartmentss Human 95% 0.05335 mg/L 0.0003049 mg/L 174.975401771072 -DTXSID2047355 Css 3compartmentss Human 95% 5.799 mg/L 3.085 mg/L 1.87974068071313 -DTXSID2047357 Css 3compartmentss Human 95% 13700 mg/L 8016 mg/L 1.70908183632735 -DTXSID2047359 Css 3compartmentss Human 95% 1.728 mg/L 1.082 mg/L 1.59704251386322 -DTXSID2047434 Css 3compartmentss Human 95% 0.5394 mg/L 0.2955 mg/L 1.8253807106599 -DTXSID2047436 Css 3compartmentss Human 95% 30.73 mg/L 18.11 mg/L 1.69685256764219 -DTXSID2047484 Css 3compartmentss Human 95% 18.35 mg/L 27.08 mg/L 0.677621861152142 -DTXSID2047486 Css 3compartmentss Human 95% 0.145 mg/L 0.08323 mg/L 1.74216027874564 -DTXSID2047511 Css 3compartmentss Human 95% 8.847 mg/L 2.17e-07 mg/L 40769585.2534562 -DTXSID2047517 Css 3compartmentss Human 95% 0.3052 mg/L 0 mg/L Inf -DTXSID2047569 Css 3compartmentss Human 95% 9.739 mg/L 5.649 mg/L 1.72402195078775 -DTXSID2047644 Css 3compartmentss Human 95% 1.584 mg/L 1.102 mg/L 1.43738656987296 -DTXSID2047694 Css 3compartmentss Human 95% 1.623 mg/L 1.182 mg/L 1.37309644670051 -DTXSID2047696 Css 3compartmentss Human 95% 0.917 mg/L 0.5486 mg/L 1.67152752460809 -DTXSID2047721 Css 3compartmentss Human 95% 6.929 mg/L 4.416 mg/L 1.56906702898551 -DTXSID2047725 Css 3compartmentss Human 95% 7.398 mg/L 2.621 mg/L 2.82258679893171 -DTXSID2047727 Css 3compartmentss Human 95% 1.118 mg/L 0.704 mg/L 1.58806818181818 -DTXSID2047773 Css 3compartmentss Human 95% 3.095 mg/L 1.758 mg/L 1.76052332195677 -DTXSID2047775 Css 3compartmentss Human 95% 0.7654 mg/L 0.6129 mg/L 1.24881709903736 -DTXSID2047777 Css 3compartmentss Human 95% 15.91 mg/L 4.875 mg/L 3.26358974358974 -DTXSID2047779 Css 3compartmentss Human 95% 10.25 mg/L 1.049 mg/L 9.77121067683508 -DTXSID2047800 Css 3compartmentss Human 95% 7.463 mg/L 4.889 mg/L 1.52648803436286 -DTXSID2047804 Css 3compartmentss Human 95% 21.97 mg/L 12.59 mg/L 1.7450357426529 -DTXSID2047850 Css 3compartmentss Human 95% 1.695 mg/L 0.7321 mg/L 2.31525747848655 -DTXSID2047852 Css 3compartmentss Human 95% 1.742 mg/L 1.046 mg/L 1.66539196940727 -DTXSID2047856 Css 3compartmentss Human 95% 1.226 mg/L 0.1612 mg/L 7.60545905707196 -DTXSID2047858 Css 3compartmentss Human 95% 0.03626 mg/L 0.008739 mg/L 4.14921615745509 -DTXSID2047939 Css 3compartmentss Human 95% 4.507 mg/L 2.781 mg/L 1.62064005753326 -DTXSID2048161 Css 3compartmentss Human 95% 0.8085 mg/L 0.1311 mg/L 6.16704805491991 -DTXSID2048169 Css 3compartmentss Human 95% 13.41 mg/L 8.586 mg/L 1.56184486373166 -DTXSID2048379 Css 3compartmentss Human 95% 2.896 mg/L 1.808 mg/L 1.60176991150442 -DTXSID2048539 Css 3compartmentss Human 95% 0.8563 mg/L 0.6574 mg/L 1.30255552175236 -DTXSID2048581 Css 3compartmentss Human 95% 14.21 mg/L 9.062 mg/L 1.56808651511808 -DTXSID2048583 Css 3compartmentss Human 95% 12.85 mg/L 7.578 mg/L 1.69569807337028 -DTXSID2048585 Css 3compartmentss Human 95% 43.79 mg/L 24.12 mg/L 1.81550580431177 -DTXSID2048587 Css 3compartmentss Human 95% 7.38 mg/L 4.803 mg/L 1.53653966271081 -DTXSID2048589 Css 3compartmentss Human 95% 2.702 mg/L 0.003093 mg/L 873.585515680569 -DTXSID2048610 Css 3compartmentss Human 95% 20.76 mg/L 10.82 mg/L 1.91866913123845 -DTXSID2048612 Css 3compartmentss Human 95% 3.344 mg/L 3.171 mg/L 1.05455692210659 -DTXSID2048614 Css 3compartmentss Human 95% 3.624 mg/L 0.06021 mg/L 60.1893373193822 -DTXSID2048616 Css 3compartmentss Human 95% 6.561 mg/L 4.115 mg/L 1.59441069258809 -DTXSID2048618 Css 3compartmentss Human 95% 10.34 mg/L 6.086 mg/L 1.69898126848505 -DTXSID2048660 Css 3compartmentss Human 95% 45.67 mg/L 24.81 mg/L 1.84079000403063 -DTXSID2048662 Css 3compartmentss Human 95% 0.4179 mg/L 0.3151 mg/L 1.32624563630593 -DTXSID2048664 Css 3compartmentss Human 95% 0.7329 mg/L 1.13e-07 mg/L 6485840.7079646 -DTXSID2048666 Css 3compartmentss Human 95% 30.58 mg/L 22.4 mg/L 1.36517857142857 -DTXSID2048668 Css 3compartmentss Human 95% 2.808 mg/L 1.534 mg/L 1.83050847457627 -DTXSID2048741 Css 3compartmentss Human 95% 8.699 mg/L 5.275 mg/L 1.64909952606635 -DTXSID2048743 Css 3compartmentss Human 95% 2.346 mg/L 1.218 mg/L 1.92610837438424 -DTXSID2048745 Css 3compartmentss Human 95% 1.741 mg/L 1.005 mg/L 1.73233830845771 -DTXSID2048747 Css 3compartmentss Human 95% 4.655 mg/L 2.72 mg/L 1.71139705882353 -DTXSID2048749 Css 3compartmentss Human 95% 0.1601 mg/L 0.06964 mg/L 2.29896611143021 -DTXSID2048791 Css 3compartmentss Human 95% 0.1834 mg/L 0.08431 mg/L 2.17530542047207 -DTXSID2048793 Css 3compartmentss Human 95% 0.2123 mg/L 0.1259 mg/L 1.68625893566322 -DTXSID2048795 Css 3compartmentss Human 95% 79.02 mg/L 45.97 mg/L 1.71894713943876 -DTXSID2048797 Css 3compartmentss Human 95% 0.2009 mg/L 0.004082 mg/L 49.2160705536502 -DTXSID2048799 Css 3compartmentss Human 95% 7.631 mg/L 4.894 mg/L 1.55925623212096 -DTXSID2048820 Css 3compartmentss Human 95% 14.12 mg/L 9.882 mg/L 1.42886055454361 -DTXSID2048822 Css 3compartmentss Human 95% 21.25 mg/L 12.17 mg/L 1.74609695973706 -DTXSID2048826 Css 3compartmentss Human 95% 25.02 mg/L 13.98 mg/L 1.78969957081545 -DTXSID2048828 Css 3compartmentss Human 95% 4.951 mg/L 3.443 mg/L 1.43799012489108 -DTXSID2048870 Css 3compartmentss Human 95% 0.185 mg/L 0.1412 mg/L 1.31019830028329 -DTXSID2048872 Css 3compartmentss Human 95% 0.6371 mg/L 0.3187 mg/L 1.99905867587072 -DTXSID2048874 Css 3compartmentss Human 95% 11.41 mg/L 8.352 mg/L 1.3661398467433 -DTXSID2048876 Css 3compartmentss Human 95% 0.696 mg/L 0.4904 mg/L 1.41924959216966 -DTXSID2048878 Css 3compartmentss Human 95% 0.05503 mg/L 0.03853 mg/L 1.42823773682845 -DTXSID2048901 Css 3compartmentss Human 95% 0.3231 mg/L 0.2139 mg/L 1.51051893408135 -DTXSID2048903 Css 3compartmentss Human 95% 0.4085 mg/L 0.3056 mg/L 1.33671465968586 -DTXSID2048905 Css 3compartmentss Human 95% 6.787 mg/L 0.2346 mg/L 28.9300937766411 -DTXSID2048907 Css 3compartmentss Human 95% 0.2812 mg/L 0.2248 mg/L 1.2508896797153 -DTXSID2048909 Css 3compartmentss Human 95% 1.095 mg/L 0.7286 mg/L 1.50288223991216 -DTXSID2048953 Css 3compartmentss Human 95% 15.94 mg/L 7.754 mg/L 2.05571318029404 -DTXSID2048955 Css 3compartmentss Human 95% 17.05 mg/L 9.794 mg/L 1.74086175209312 -DTXSID2048957 Css 3compartmentss Human 95% 4.372 mg/L 5.509e-06 mg/L 793610.45561808 -DTXSID2048959 Css 3compartmentss Human 95% 5.695 mg/L 3.591 mg/L 1.58590921748816 -DTXSID2049000 Css 3compartmentss Human 95% 43.55 mg/L 20.21 mg/L 2.15487382483919 -DTXSID2049002 Css 3compartmentss Human 95% 70.35 mg/L 39.15 mg/L 1.79693486590038 -DTXSID2049004 Css 3compartmentss Human 95% 5.459 mg/L 1.986 mg/L 2.74874118831823 -DTXSID2049006 Css 3compartmentss Human 95% 3.713 mg/L 2.24 mg/L 1.65758928571429 -DTXSID2049008 Css 3compartmentss Human 95% 92.7 mg/L 228.3 mg/L 0.406044678055191 -DTXSID2049050 Css 3compartmentss Human 95% 0.9099 mg/L 0.07324 mg/L 12.4235390496996 -DTXSID2049052 Css 3compartmentss Human 95% 0.6899 mg/L 0.3742 mg/L 1.84366648850882 -DTXSID2049054 Css 3compartmentss Human 95% 25.51 mg/L 11.23 mg/L 2.27159394479074 -DTXSID2049056 Css 3compartmentss Human 95% 1.401 mg/L 0.9127 mg/L 1.53500602607648 -DTXSID2049058 Css 3compartmentss Human 95% 1.042 mg/L 0.615 mg/L 1.69430894308943 -DTXSID2049135 Css 3compartmentss Human 95% 12.85 mg/L 7.578 mg/L 1.69569807337028 -DTXSID2049210 Css 3compartmentss Human 95% 13.71 mg/L 8.755 mg/L 1.565962307253 -DTXSID2049216 Css 3compartmentss Human 95% 3.893 mg/L 9739 mg/L 0.000399733032138823 -DTXSID2049260 Css 3compartmentss Human 95% 18.12 mg/L 4.484 mg/L 4.04103479036575 -DTXSID2049262 Css 3compartmentss Human 95% 0.9885 mg/L 0.6625 mg/L 1.49207547169811 -DTXSID2049268 Css 3compartmentss Human 95% 49.22 mg/L 29.24 mg/L 1.68331053351573 -DTXSID2049391 Css 3compartmentss Human 95% 0.02646 mg/L 0 mg/L Inf -DTXSID2049393 Css 3compartmentss Human 95% 2.395 mg/L 1.279 mg/L 1.87255668491009 -DTXSID2049397 Css 3compartmentss Human 95% 1.19 mg/L 0 mg/L Inf -DTXSID2049399 Css 3compartmentss Human 95% 5.464 mg/L 3.873 mg/L 1.41079266718306 -DTXSID2049420 Css 3compartmentss Human 95% 4.322 mg/L 2.735 mg/L 1.58025594149909 -DTXSID2049422 Css 3compartmentss Human 95% 0.2956 mg/L 0.2232 mg/L 1.32437275985663 -DTXSID2049424 Css 3compartmentss Human 95% 3.592 mg/L 2.4 mg/L 1.49666666666667 -DTXSID2049426 Css 3compartmentss Human 95% 5.573 mg/L 4.119 mg/L 1.35299830055839 -DTXSID2049428 Css 3compartmentss Human 95% 5.902 mg/L 3.74 mg/L 1.57807486631016 -DTXSID2051631 Css 3compartmentss Human 95% 0.1454 mg/L 0.09501 mg/L 1.53036522471319 -DTXSID2051687 Css 3compartmentss Human 95% 8.154 mg/L 4.299 mg/L 1.89672016748081 -DTXSID2051716 Css 3compartmentss Human 95% 4.747 mg/L 2.761 mg/L 1.71930459978269 -DTXSID2052281 Css 3compartmentss Human 95% 4.943 mg/L 3.08 mg/L 1.60487012987013 -DTXSID2052283 Css 3compartmentss Human 95% 5.433 mg/L 3.66 mg/L 1.4844262295082 -DTXSID2052289 Css 3compartmentss Human 95% 4.131 mg/L 3.149 mg/L 1.31184503016831 -DTXSID2052310 Css 3compartmentss Human 95% 1.665 mg/L 1.075 mg/L 1.54883720930233 -DTXSID2052574 Css 3compartmentss Human 95% 2.19 mg/L 1.334 mg/L 1.64167916041979 -DTXSID2052603 Css 3compartmentss Human 95% 29.56 mg/L 24.43 mg/L 1.20998772001637 -DTXSID2052607 Css 3compartmentss Human 95% 0.155 mg/L 0.104 mg/L 1.49038461538462 -DTXSID2057601 Css 3compartmentss Human 95% 17.22 mg/L 9.334 mg/L 1.84486822369831 -DTXSID2057603 Css 3compartmentss Human 95% 0.4236 mg/L 0.2844 mg/L 1.48945147679325 -DTXSID2057609 Css 3compartmentss Human 95% 2.8 mg/L 1.501 mg/L 1.86542305129913 -DTXSID2057651 Css 3compartmentss Human 95% 2.355 mg/L 0.7625 mg/L 3.08852459016393 -DTXSID2057653 Css 3compartmentss Human 95% 3.448 mg/L 1.879 mg/L 1.83501862692922 -DTXSID2057655 Css 3compartmentss Human 95% 0.4743 mg/L 0.3506 mg/L 1.35282373074729 -DTXSID2057657 Css 3compartmentss Human 95% 0.8856 mg/L 0.6274 mg/L 1.41153968759962 -DTXSID2057659 Css 3compartmentss Human 95% 5.851 mg/L 3.908 mg/L 1.49718526100307 -DTXSID2057730 Css 3compartmentss Human 95% 0.722 mg/L 1e-09 mg/L 7.22e+08 -DTXSID2057732 Css 3compartmentss Human 95% 2.208 mg/L 1.392 mg/L 1.58620689655172 -DTXSID2057734 Css 3compartmentss Human 95% 0.3452 mg/L 0.2504 mg/L 1.37859424920128 -DTXSID2057736 Css 3compartmentss Human 95% 2.627 mg/L 1.52 mg/L 1.72828947368421 -DTXSID2057738 Css 3compartmentss Human 95% 0.9982 mg/L 0.7142 mg/L 1.39764771772613 -DTXSID2057782 Css 3compartmentss Human 95% 5.765 mg/L 3.186 mg/L 1.80947897049592 -DTXSID2057784 Css 3compartmentss Human 95% 0.3219 mg/L 0.1941 mg/L 1.65842349304482 -DTXSID2057811 Css 3compartmentss Human 95% 8.797 mg/L 5.352 mg/L 1.6436846038864 -DTXSID2057813 Css 3compartmentss Human 95% 0.5745 mg/L 0.3713 mg/L 1.5472663614328 -DTXSID2057815 Css 3compartmentss Human 95% 35.42 mg/L 15.1 mg/L 2.34569536423841 -DTXSID2057817 Css 3compartmentss Human 95% 2.269 mg/L 1.27 mg/L 1.78661417322835 -DTXSID2057819 Css 3compartmentss Human 95% 1.434 mg/L 1.067 mg/L 1.34395501405811 -DTXSID30166683 Css 3compartmentss Human 95% 10.24 mg/L 9.451 mg/L 1.08348322928791 -DTXSID3020043 Css 3compartmentss Human 95% 5.728 mg/L 3.628 mg/L 1.57883131201764 -DTXSID3020047 Css 3compartmentss Human 95% 3.194 mg/L 2.093 mg/L 1.52603917821309 -DTXSID3020091 Css 3compartmentss Human 95% 0.9464 mg/L 0.6721 mg/L 1.40812379110251 -DTXSID3020093 Css 3compartmentss Human 95% 0.1034 mg/L 0.071 mg/L 1.45633802816901 -DTXSID3020095 Css 3compartmentss Human 95% 10.61 mg/L 6.502 mg/L 1.63180559827745 -DTXSID3020097 Css 3compartmentss Human 95% 0.5823 mg/L 0.1067 mg/L 5.45735707591378 -DTXSID3020099 Css 3compartmentss Human 95% 8.016 mg/L 3.99 mg/L 2.00902255639098 -DTXSID3020120 Css 3compartmentss Human 95% 1.45 mg/L 0.2146 mg/L 6.75675675675676 -DTXSID3020122 Css 3compartmentss Human 95% 0.7085 mg/L 0.6071 mg/L 1.16702355460385 -DTXSID3020128 Css 3compartmentss Human 95% 6.205 mg/L 4.099 mg/L 1.51378384971944 -DTXSID3020207 Css 3compartmentss Human 95% 10670 mg/L 6140 mg/L 1.73778501628665 -DTXSID3020209 Css 3compartmentss Human 95% 3.238 mg/L 1.699 mg/L 1.90582695703355 -DTXSID3020253 Css 3compartmentss Human 95% 0.002773 mg/L 0 mg/L Inf -DTXSID3020257 Css 3compartmentss Human 95% 5.287 mg/L 2.937 mg/L 1.80013619339462 -DTXSID3020330 Css 3compartmentss Human 95% 6.252 mg/L 3.09 mg/L 2.02330097087379 -DTXSID3020332 Css 3compartmentss Human 95% 5.842 mg/L 3.741 mg/L 1.56161454156643 -DTXSID3020336 Css 3compartmentss Human 95% 0.8458 mg/L 0.3188 mg/L 2.65307402760351 -DTXSID3020380 Css 3compartmentss Human 95% 3.224 mg/L 1.137 mg/L 2.83553210202287 -DTXSID3020384 Css 3compartmentss Human 95% 2.712 mg/L 1.988 mg/L 1.36418511066398 -DTXSID3020419 Css 3compartmentss Human 95% 0.5939 mg/L 0.2048 mg/L 2.89990234375 -DTXSID3020463 Css 3compartmentss Human 95% 1.075 mg/L 0.6765 mg/L 1.58906134515891 -DTXSID3020465 Css 3compartmentss Human 95% 6.226 mg/L 0.7528 mg/L 8.27045696068013 -DTXSID3020469 Css 3compartmentss Human 95% 1.338 mg/L 0.9496 mg/L 1.40901432181971 -DTXSID3020540 Css 3compartmentss Human 95% 2.795 mg/L 1.41 mg/L 1.9822695035461 -DTXSID3020546 Css 3compartmentss Human 95% 2.183 mg/L 1.618 mg/L 1.34919653893696 -DTXSID3020598 Css 3compartmentss Human 95% 3.292 mg/L 2.385 mg/L 1.38029350104822 -DTXSID3020621 Css 3compartmentss Human 95% 482.8 mg/L 0.06061 mg/L 7965.68223065501 -DTXSID3020625 Css 3compartmentss Human 95% 8.079 mg/L 4.6 mg/L 1.75630434782609 -DTXSID3020627 Css 3compartmentss Human 95% 1.648 mg/L 1.148 mg/L 1.43554006968641 -DTXSID3020629 Css 3compartmentss Human 95% 58.39 mg/L 9.296 mg/L 6.28119621342513 -DTXSID3020671 Css 3compartmentss Human 95% 65.91 mg/L 24.09 mg/L 2.7359900373599 -DTXSID3020673 Css 3compartmentss Human 95% 257.9 mg/L 153.7 mg/L 1.6779440468445 -DTXSID3020700 Css 3compartmentss Human 95% 5.584 mg/L 3.628 mg/L 1.53914002205072 -DTXSID3020704 Css 3compartmentss Human 95% 0.2886 mg/L 0.1683 mg/L 1.71479500891266 -DTXSID3020706 Css 3compartmentss Human 95% 0.5834 mg/L 0.3608 mg/L 1.6169623059867 -DTXSID3020708 Css 3compartmentss Human 95% 11.62 mg/L 6.958 mg/L 1.67002012072435 -DTXSID3020750 Css 3compartmentss Human 95% 4.977 mg/L 4.256 mg/L 1.16940789473684 -DTXSID3020756 Css 3compartmentss Human 95% 1.763 mg/L 1.084 mg/L 1.62638376383764 -DTXSID3020835 Css 3compartmentss Human 95% 3.311 mg/L 2.261 mg/L 1.46439628482972 -DTXSID3020881 Css 3compartmentss Human 95% 0.4353 mg/L 0.3352 mg/L 1.2986276849642 -DTXSID3020910 Css 3compartmentss Human 95% 1.908 mg/L 1.172 mg/L 1.62798634812287 -DTXSID3020912 Css 3compartmentss Human 95% 2.307 mg/L 1.507 mg/L 1.53085600530856 -DTXSID3020914 Css 3compartmentss Human 95% 2.374 mg/L 1.382 mg/L 1.7178002894356 -DTXSID3020916 Css 3compartmentss Human 95% 7.598 mg/L 5.202 mg/L 1.46059207996924 -DTXSID3020918 Css 3compartmentss Human 95% 4.411 mg/L 2.88e-07 mg/L 15315972.2222222 -DTXSID3020960 Css 3compartmentss Human 95% 14.48 mg/L 6.174 mg/L 2.34531908001296 -DTXSID3020962 Css 3compartmentss Human 95% 0.374 mg/L 0.2347 mg/L 1.5935236472092 -DTXSID3020964 Css 3compartmentss Human 95% 0.953 mg/L 0.6776 mg/L 1.40643447461629 -DTXSID3020966 Css 3compartmentss Human 95% 28.5 mg/L 16.96 mg/L 1.68042452830189 -DTXSID3021065 Css 3compartmentss Human 95% 1.025 mg/L 0.6647 mg/L 1.54204904468181 -DTXSID3021069 Css 3compartmentss Human 95% 1.65 mg/L 1.048 mg/L 1.57442748091603 -DTXSID3021140 Css 3compartmentss Human 95% 0.1977 mg/L 0.09451 mg/L 2.09184213310761 -DTXSID3021142 Css 3compartmentss Human 95% 0.1714 mg/L 0.09727 mg/L 1.76210547959289 -DTXSID3021144 Css 3compartmentss Human 95% 0.4862 mg/L 0.3599 mg/L 1.35093081411503 -DTXSID3021148 Css 3compartmentss Human 95% 0.4211 mg/L 0.2834 mg/L 1.48588567395907 -DTXSID3021190 Css 3compartmentss Human 95% 0.1674 mg/L 0.1033 mg/L 1.62052274927396 -DTXSID3021192 Css 3compartmentss Human 95% 38.07 mg/L 2.875 mg/L 13.2417391304348 -DTXSID3021196 Css 3compartmentss Human 95% 10.2 mg/L 4.891 mg/L 2.0854630954815 -DTXSID3021198 Css 3compartmentss Human 95% 0.07077 mg/L 0.03092 mg/L 2.28880983182406 -DTXSID3021221 Css 3compartmentss Human 95% 53.44 mg/L 31.16 mg/L 1.71501925545571 -DTXSID3021223 Css 3compartmentss Human 95% 1.122 mg/L 0.8631 mg/L 1.29996524157108 -DTXSID3021275 Css 3compartmentss Human 95% 2.559 mg/L 1.591 mg/L 1.60842237586424 -DTXSID3021277 Css 3compartmentss Human 95% 6.933 mg/L 4.213 mg/L 1.64562069784002 -DTXSID3021304 Css 3compartmentss Human 95% 5.542 mg/L 3.307 mg/L 1.67583912912005 -DTXSID3021354 Css 3compartmentss Human 95% 0.1047 mg/L 0.06536 mg/L 1.60189718482252 -DTXSID3021356 Css 3compartmentss Human 95% 0.00508 mg/L 0 mg/L Inf -DTXSID3021358 Css 3compartmentss Human 95% 37.66 mg/L 22.5 mg/L 1.67377777777778 -DTXSID3021483 Css 3compartmentss Human 95% 1.463 mg/L 0.9559 mg/L 1.53049482163406 -DTXSID3021485 Css 3compartmentss Human 95% 16.05 mg/L 9.729 mg/L 1.64970706136294 -DTXSID3021487 Css 3compartmentss Human 95% 11.88 mg/L 7.427 mg/L 1.59956913962569 -DTXSID3021518 Css 3compartmentss Human 95% 8.733 mg/L 5.464 mg/L 1.59827964860908 -DTXSID3021562 Css 3compartmentss Human 95% 5.124 mg/L 4.251 mg/L 1.20536344389555 -DTXSID3021641 Css 3compartmentss Human 95% 18.11 mg/L 10.39 mg/L 1.74302213666987 -DTXSID3021647 Css 3compartmentss Human 95% 8.246 mg/L 5.115 mg/L 1.61212121212121 -DTXSID3021726 Css 3compartmentss Human 95% 2.537 mg/L 1.801 mg/L 1.40866185452526 -DTXSID3021770 Css 3compartmentss Human 95% 8.756 mg/L 0.007778 mg/L 1125.73926459244 -DTXSID3021772 Css 3compartmentss Human 95% 7.749 mg/L 5.484 mg/L 1.41301969365427 -DTXSID3021778 Css 3compartmentss Human 95% 0.6144 mg/L 0.2892 mg/L 2.12448132780083 -DTXSID3021801 Css 3compartmentss Human 95% 1.385 mg/L 0.8519 mg/L 1.62577767343585 -DTXSID3021803 Css 3compartmentss Human 95% 4.728 mg/L 2.587 mg/L 1.82759953614225 -DTXSID3021805 Css 3compartmentss Human 95% 0.375 mg/L 0.1648 mg/L 2.2754854368932 -DTXSID3021851 Css 3compartmentss Human 95% 3.173 mg/L 2.577 mg/L 1.23127667830811 -DTXSID3021853 Css 3compartmentss Human 95% 3.75 mg/L 2.585 mg/L 1.45067698259188 -DTXSID3021930 Css 3compartmentss Human 95% 1.214 mg/L 0.8338 mg/L 1.45598464859679 -DTXSID3021932 Css 3compartmentss Human 95% 2.353 mg/L 1.585 mg/L 1.48454258675079 -DTXSID3021936 Css 3compartmentss Human 95% 5.012 mg/L 3.149 mg/L 1.59161638615433 -DTXSID3021984 Css 3compartmentss Human 95% 0.1089 mg/L 0.00296 mg/L 36.7905405405405 -DTXSID3021986 Css 3compartmentss Human 95% 271.1 mg/L 476.6 mg/L 0.568820814099874 -DTXSID3022035 Css 3compartmentss Human 95% 27.38 mg/L 45.27 mg/L 0.604815551137619 -DTXSID3022085 Css 3compartmentss Human 95% 0.08717 mg/L 0.05597 mg/L 1.55744148651063 -DTXSID3022089 Css 3compartmentss Human 95% 3.459 mg/L 2.194 mg/L 1.57657247037375 -DTXSID3022160 Css 3compartmentss Human 95% 13.26 mg/L 6.706 mg/L 1.97733373098718 -DTXSID3022162 Css 3compartmentss Human 95% 0.4169 mg/L 0.5342 mg/L 0.780419318607263 -DTXSID3022164 Css 3compartmentss Human 95% 2.061 mg/L 1.596 mg/L 1.29135338345865 -DTXSID3022247 Css 3compartmentss Human 95% 4.442 mg/L 0.2546 mg/L 17.4469756480754 -DTXSID3022320 Css 3compartmentss Human 95% 12.49 mg/L 0.01826 mg/L 684.008762322015 -DTXSID3022326 Css 3compartmentss Human 95% 10.44 mg/L 6.436 mg/L 1.62212554381603 -DTXSID3022370 Css 3compartmentss Human 95% 7.116 mg/L 2.192 mg/L 3.2463503649635 -DTXSID3022401 Css 3compartmentss Human 95% 0.03882 mg/L 0 mg/L Inf -DTXSID3022403 Css 3compartmentss Human 95% 1.617 mg/L 1.099 mg/L 1.47133757961783 -DTXSID3022405 Css 3compartmentss Human 95% 15.51 mg/L 5.176 mg/L 2.99652241112828 -DTXSID3022409 Css 3compartmentss Human 95% 58.14 mg/L 33.64 mg/L 1.72829964328181 -DTXSID3022455 Css 3compartmentss Human 95% 7.659 mg/L 5.851 mg/L 1.30900700734917 -DTXSID3022536 Css 3compartmentss Human 95% 5.603 mg/L 2.01 mg/L 2.78756218905473 -DTXSID3022582 Css 3compartmentss Human 95% 57.66 mg/L 110 mg/L 0.524181818181818 -DTXSID3022584 Css 3compartmentss Human 95% 1.069 mg/L 1.074 mg/L 0.995344506517691 -DTXSID3022586 Css 3compartmentss Human 95% 5.092 mg/L 3.493 mg/L 1.45777268823361 -DTXSID3022588 Css 3compartmentss Human 95% 6.255 mg/L 4.083 mg/L 1.53196179279941 -DTXSID3022611 Css 3compartmentss Human 95% 315.1 mg/L 177.3 mg/L 1.77721376198534 -DTXSID3022617 Css 3compartmentss Human 95% 2.676 mg/L 1.866 mg/L 1.43408360128617 -DTXSID3022663 Css 3compartmentss Human 95% 450.8 mg/L 4.222 mg/L 106.774040738986 -DTXSID3022667 Css 3compartmentss Human 95% 1.752 mg/L 1.154 mg/L 1.51819757365685 -DTXSID3022742 Css 3compartmentss Human 95% 9.257 mg/L 5.279 mg/L 1.75355180905475 -DTXSID3022748 Css 3compartmentss Human 95% 4.44 mg/L 2.713 mg/L 1.63656468853668 -DTXSID3022796 Css 3compartmentss Human 95% 14.08 mg/L 8.813 mg/L 1.59763985022126 -DTXSID3022798 Css 3compartmentss Human 95% 11.29 mg/L 11.76 mg/L 0.960034013605442 -DTXSID3022821 Css 3compartmentss Human 95% 1.022 mg/L 0.002 mg/L 511 -DTXSID3022825 Css 3compartmentss Human 95% 6.68 mg/L 0.8891 mg/L 7.51321561129232 -DTXSID3022829 Css 3compartmentss Human 95% 1.045 mg/L 0.7648 mg/L 1.36637029288703 -DTXSID3022871 Css 3compartmentss Human 95% 11.96 mg/L 7.256 mg/L 1.64829106945976 -DTXSID3022873 Css 3compartmentss Human 95% 17.4 mg/L 11.13 mg/L 1.5633423180593 -DTXSID3022875 Css 3compartmentss Human 95% 6.966 mg/L 4.65 mg/L 1.49806451612903 -DTXSID3022877 Css 3compartmentss Human 95% 5.411 mg/L 3.616 mg/L 1.49640486725664 -DTXSID3022902 Css 3compartmentss Human 95% 15.53 mg/L 9.477 mg/L 1.63870423129682 -DTXSID3022904 Css 3compartmentss Human 95% 6.052 mg/L 3.247 mg/L 1.86387434554974 -DTXSID3022906 Css 3compartmentss Human 95% 5.267 mg/L 3.573 mg/L 1.47411139098797 -DTXSID3022908 Css 3compartmentss Human 95% 0.05067 mg/L 0.01724 mg/L 2.93909512761021 -DTXSID3022950 Css 3compartmentss Human 95% 0.6993 mg/L 0.1772 mg/L 3.94638826185102 -DTXSID3022956 Css 3compartmentss Human 95% 2.559 mg/L 1.591 mg/L 1.60842237586424 -DTXSID3022958 Css 3compartmentss Human 95% 1.194 mg/L 0.732 mg/L 1.63114754098361 -DTXSID3023001 Css 3compartmentss Human 95% 4845 mg/L 9739 mg/L 0.497484341308143 -DTXSID3023005 Css 3compartmentss Human 95% 27.73 mg/L 14.1 mg/L 1.96666666666667 -DTXSID3023007 Css 3compartmentss Human 95% 0.3983 mg/L 0.2645 mg/L 1.50586011342155 -DTXSID3023051 Css 3compartmentss Human 95% 168.2 mg/L 91.46 mg/L 1.83905532473212 -DTXSID3023057 Css 3compartmentss Human 95% 5.873 mg/L 3.612 mg/L 1.62596899224806 -DTXSID3023059 Css 3compartmentss Human 95% 5.048 mg/L 3.539 mg/L 1.42639163605538 -DTXSID3023132 Css 3compartmentss Human 95% 3.021 mg/L 1.755 mg/L 1.72136752136752 -DTXSID3023180 Css 3compartmentss Human 95% 1.525 mg/L 0.009425 mg/L 161.803713527851 -DTXSID3023188 Css 3compartmentss Human 95% 1.936 mg/L 1.058 mg/L 1.82986767485822 -DTXSID3023219 Css 3compartmentss Human 95% 4.156 mg/L 1.635 mg/L 2.54189602446483 -DTXSID3023261 Css 3compartmentss Human 95% 5.848 mg/L 3.288 mg/L 1.77858880778589 -DTXSID3023265 Css 3compartmentss Human 95% 5.316 mg/L 1.668 mg/L 3.18705035971223 -DTXSID3023269 Css 3compartmentss Human 95% 0.7205 mg/L 0.4941 mg/L 1.4582068407205 -DTXSID3023340 Css 3compartmentss Human 95% 5.071 mg/L 2.126 mg/L 2.38523047977422 -DTXSID3023342 Css 3compartmentss Human 95% 1.953 mg/L 1.299 mg/L 1.50346420323326 -DTXSID3023396 Css 3compartmentss Human 95% 7.965 mg/L 5.974 mg/L 1.33327753598929 -DTXSID3023398 Css 3compartmentss Human 95% 1.58 mg/L 1.175 mg/L 1.34468085106383 -DTXSID3023425 Css 3compartmentss Human 95% 0.67 mg/L 0.1918 mg/L 3.49322210636079 -DTXSID3023427 Css 3compartmentss Human 95% 2.706 mg/L 1.661 mg/L 1.62913907284768 -DTXSID3023471 Css 3compartmentss Human 95% 2.423 mg/L 1.58 mg/L 1.53354430379747 -DTXSID3023479 Css 3compartmentss Human 95% 0.9221 mg/L 0.5606 mg/L 1.64484480913307 -DTXSID3023502 Css 3compartmentss Human 95% 1.937 mg/L 1.644 mg/L 1.17822384428224 -DTXSID3023550 Css 3compartmentss Human 95% 3.068 mg/L 0.4254 mg/L 7.21203573107663 -DTXSID3023552 Css 3compartmentss Human 95% 464.1 mg/L 275.7 mg/L 1.68335146898803 -DTXSID3023554 Css 3compartmentss Human 95% 13.39 mg/L 4.797 mg/L 2.79132791327913 -DTXSID3023681 Css 3compartmentss Human 95% 0.1644 mg/L 0.07462 mg/L 2.20316269096757 -DTXSID3023685 Css 3compartmentss Human 95% 11.04 mg/L 6.056 mg/L 1.82298546895641 -DTXSID3023687 Css 3compartmentss Human 95% 0.1288 mg/L 0.0001395 mg/L 923.297491039427 -DTXSID3023712 Css 3compartmentss Human 95% 0.01326 mg/L 0.009056 mg/L 1.46422261484099 -DTXSID3023716 Css 3compartmentss Human 95% 31.84 mg/L 16.3 mg/L 1.95337423312883 -DTXSID3023718 Css 3compartmentss Human 95% 5.438 mg/L 2.084 mg/L 2.60940499040307 -DTXSID3023764 Css 3compartmentss Human 95% 9.318 mg/L 0.0002741 mg/L 33994.8923750456 -DTXSID3023897 Css 3compartmentss Human 95% 2.563 mg/L 1.571 mg/L 1.63144493952896 -DTXSID3023974 Css 3compartmentss Human 95% 6.417 mg/L 4.212 mg/L 1.52350427350427 -DTXSID3024100 Css 3compartmentss Human 95% 0.1827 mg/L 0.1045 mg/L 1.74832535885167 -DTXSID3024102 Css 3compartmentss Human 95% 2.567 mg/L 1.292 mg/L 1.98684210526316 -DTXSID3024104 Css 3compartmentss Human 95% 21.5 mg/L 0.9362 mg/L 22.9651783806879 -DTXSID3024108 Css 3compartmentss Human 95% 244.6 mg/L 207.2 mg/L 1.18050193050193 -DTXSID3024152 Css 3compartmentss Human 95% 6.961 mg/L 4.166 mg/L 1.67090734517523 -DTXSID3024154 Css 3compartmentss Human 95% 4.464 mg/L 2.756 mg/L 1.61973875181422 -DTXSID3024235 Css 3compartmentss Human 95% 24.64 mg/L 10.44 mg/L 2.36015325670498 -DTXSID3024239 Css 3compartmentss Human 95% 2713 mg/L 1579 mg/L 1.71817606079797 -DTXSID3024287 Css 3compartmentss Human 95% 2.703 mg/L 1.71 mg/L 1.58070175438596 -DTXSID3024289 Css 3compartmentss Human 95% 57.33 mg/L 2.533 mg/L 22.6332412159495 -DTXSID3024316 Css 3compartmentss Human 95% 1.245 mg/L 0.8238 mg/L 1.51128914785142 -DTXSID3024318 Css 3compartmentss Human 95% 3.064 mg/L 1.771 mg/L 1.73009599096556 -DTXSID3024364 Css 3compartmentss Human 95% 0.6358 mg/L 0.4274 mg/L 1.48759943846514 -DTXSID3024368 Css 3compartmentss Human 95% 5.327 mg/L 3.512 mg/L 1.51679954441913 -DTXSID3024441 Css 3compartmentss Human 95% 1.865 mg/L 1.165 mg/L 1.60085836909871 -DTXSID3024449 Css 3compartmentss Human 95% 2.385 mg/L 1.388 mg/L 1.71829971181556 -DTXSID3024491 Css 3compartmentss Human 95% 4.095 mg/L 2.469 mg/L 1.65856622114216 -DTXSID3024497 Css 3compartmentss Human 95% 3.337 mg/L 1.179 mg/L 2.8303647158609 -DTXSID3024499 Css 3compartmentss Human 95% 1.181 mg/L 0.8372 mg/L 1.41065456282848 -DTXSID3024522 Css 3compartmentss Human 95% 6.418 mg/L 5.987 mg/L 1.07198931017204 -DTXSID3024528 Css 3compartmentss Human 95% 0.6296 mg/L 0.4435 mg/L 1.4196166854566 -DTXSID3024574 Css 3compartmentss Human 95% 2.11 mg/L 1.278 mg/L 1.6510172143975 -DTXSID3024603 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID3024657 Css 3compartmentss Human 95% 5.578 mg/L 3.948 mg/L 1.4128672745694 -DTXSID3024736 Css 3compartmentss Human 95% 3.789 mg/L 3.953 mg/L 0.958512522135087 -DTXSID3024786 Css 3compartmentss Human 95% 10.16 mg/L 6.1 mg/L 1.6655737704918 -DTXSID3024815 Css 3compartmentss Human 95% 1.586 mg/L 1.092 mg/L 1.45238095238095 -DTXSID3024861 Css 3compartmentss Human 95% 4.111 mg/L 0.3135 mg/L 13.1132376395534 -DTXSID3024869 Css 3compartmentss Human 95% 11.33 mg/L 10.64 mg/L 1.06484962406015 -DTXSID3024940 Css 3compartmentss Human 95% 6.024 mg/L 5.813 mg/L 1.03629795286427 -DTXSID3024942 Css 3compartmentss Human 95% 5.949 mg/L 3.838 mg/L 1.5500260552371 -DTXSID3024944 Css 3compartmentss Human 95% 2.22 mg/L 1.347 mg/L 1.64810690423163 -DTXSID3024994 Css 3compartmentss Human 95% 7.836 mg/L 4.886 mg/L 1.60376586164552 -DTXSID3024998 Css 3compartmentss Human 95% 16.01 mg/L 12.01 mg/L 1.3330557868443 -DTXSID3025045 Css 3compartmentss Human 95% 2.151 mg/L 1.314 mg/L 1.63698630136986 -DTXSID3025047 Css 3compartmentss Human 95% 6.944 mg/L 4.61 mg/L 1.50629067245119 -DTXSID3025049 Css 3compartmentss Human 95% 4.976 mg/L 2.053 mg/L 2.42377009254749 -DTXSID3025091 Css 3compartmentss Human 95% 9.434 mg/L 6.948 mg/L 1.35780080598733 -DTXSID3025093 Css 3compartmentss Human 95% 0.3366 mg/L 0.1511 mg/L 2.22766379880874 -DTXSID3025122 Css 3compartmentss Human 95% 0.1655 mg/L 0.1062 mg/L 1.55838041431262 -DTXSID3025170 Css 3compartmentss Human 95% 0.05598 mg/L 0 mg/L Inf -DTXSID3025178 Css 3compartmentss Human 95% 4.218 mg/L 4.187 mg/L 1.0074038691187 -DTXSID3025203 Css 3compartmentss Human 95% 152.3 mg/L 81.6 mg/L 1.86642156862745 -DTXSID3025209 Css 3compartmentss Human 95% 904.6 mg/L 596.8 mg/L 1.51575067024129 -DTXSID3025253 Css 3compartmentss Human 95% 0.4668 mg/L 0.2792 mg/L 1.67191977077364 -DTXSID3025257 Css 3compartmentss Human 95% 16.84 mg/L 9.148 mg/L 1.84083952776563 -DTXSID3025330 Css 3compartmentss Human 95% 1.52 mg/L 1.183 mg/L 1.28486897717667 -DTXSID3025332 Css 3compartmentss Human 95% 5.535 mg/L 3.307 mg/L 1.67372240701542 -DTXSID3025338 Css 3compartmentss Human 95% 1.538 mg/L 1.021 mg/L 1.50636630754163 -DTXSID3025465 Css 3compartmentss Human 95% 1.139 mg/L 3.661e-05 mg/L 31111.7181098061 -DTXSID3025469 Css 3compartmentss Human 95% 5.849 mg/L 4.199 mg/L 1.39295070254823 -DTXSID3025540 Css 3compartmentss Human 95% 72.36 mg/L 35.11 mg/L 2.06095129592709 -DTXSID3025542 Css 3compartmentss Human 95% 7.817 mg/L 4.835 mg/L 1.61675284384695 -DTXSID3025548 Css 3compartmentss Human 95% 42.09 mg/L 0.6456 mg/L 65.1951672862454 -DTXSID3025629 Css 3compartmentss Human 95% 0.5619 mg/L 0.3615 mg/L 1.55435684647303 -DTXSID3025706 Css 3compartmentss Human 95% 23.1 mg/L 13.63 mg/L 1.69479090242113 -DTXSID3025758 Css 3compartmentss Human 95% 1.286 mg/L 1.081 mg/L 1.18963922294172 -DTXSID3025881 Css 3compartmentss Human 95% 0.1977 mg/L 0.09451 mg/L 2.09184213310761 -DTXSID3025889 Css 3compartmentss Human 95% 2.2 mg/L 1.428 mg/L 1.5406162464986 -DTXSID3026065 Css 3compartmentss Human 95% 26.74 mg/L 15.31 mg/L 1.74657086871326 -DTXSID3026067 Css 3compartmentss Human 95% 0.6362 mg/L 0.3735 mg/L 1.70334672021419 -DTXSID3026190 Css 3compartmentss Human 95% 10.19 mg/L 7.362 mg/L 1.38413474599294 -DTXSID3026223 Css 3compartmentss Human 95% 0.0154 mg/L 0.01183 mg/L 1.30177514792899 -DTXSID3026275 Css 3compartmentss Human 95% 4.889 mg/L 3.681 mg/L 1.32817169247487 -DTXSID3026279 Css 3compartmentss Human 95% 17.86 mg/L 10.94 mg/L 1.63254113345521 -DTXSID3026302 Css 3compartmentss Human 95% 5.78 mg/L 3.245 mg/L 1.78120184899846 -DTXSID3026304 Css 3compartmentss Human 95% 1.682 mg/L 1.146 mg/L 1.46771378708551 -DTXSID3026306 Css 3compartmentss Human 95% 1.915 mg/L 1.302 mg/L 1.47081413210445 -DTXSID3026308 Css 3compartmentss Human 95% 1.983 mg/L 1.388 mg/L 1.42867435158501 -DTXSID3026512 Css 3compartmentss Human 95% 0.02326 mg/L 0 mg/L Inf -DTXSID3026514 Css 3compartmentss Human 95% 9.237 mg/L 5.541 mg/L 1.66702761234434 -DTXSID3026516 Css 3compartmentss Human 95% 5.511 mg/L 3.273 mg/L 1.68377635197067 -DTXSID3026560 Css 3compartmentss Human 95% 46.9 mg/L 25.17 mg/L 1.86332936034962 -DTXSID3026562 Css 3compartmentss Human 95% 1.193 mg/L 0.7622 mg/L 1.56520598268171 -DTXSID3026564 Css 3compartmentss Human 95% 12.67 mg/L 3.914 mg/L 3.23709759836484 -DTXSID3026566 Css 3compartmentss Human 95% 6.958 mg/L 4.001 mg/L 1.73906523369158 -DTXSID3026641 Css 3compartmentss Human 95% 10.35 mg/L 7.843 mg/L 1.31964809384164 -DTXSID3026647 Css 3compartmentss Human 95% 17.22 mg/L 10.37 mg/L 1.66055930568949 -DTXSID3026697 Css 3compartmentss Human 95% 0.9191 mg/L 0 mg/L Inf -DTXSID3026724 Css 3compartmentss Human 95% 0.2449 mg/L 0.1385 mg/L 1.76823104693141 -DTXSID3026726 Css 3compartmentss Human 95% 5.096 mg/L 2.796 mg/L 1.82260371959943 -DTXSID3026851 Css 3compartmentss Human 95% 5.165 mg/L 2 mg/L 2.5825 -DTXSID3026984 Css 3compartmentss Human 95% 2.758 mg/L 2.403 mg/L 1.14773200166459 -DTXSID3027037 Css 3compartmentss Human 95% 3.556 mg/L 2.165 mg/L 1.64249422632794 -DTXSID3027039 Css 3compartmentss Human 95% 5.039 mg/L 3.324 mg/L 1.51594464500602 -DTXSID3027085 Css 3compartmentss Human 95% 0.718 mg/L 0.3428 mg/L 2.09451575262544 -DTXSID3027247 Css 3compartmentss Human 95% 9.685 mg/L 8.334 mg/L 1.16210703143749 -DTXSID3027249 Css 3compartmentss Human 95% 4.109 mg/L 2.478 mg/L 1.65819209039548 -DTXSID3027297 Css 3compartmentss Human 95% 27.64 mg/L 16.59 mg/L 1.666063893912 -DTXSID3027320 Css 3compartmentss Human 95% 0.3627 mg/L 0.2188 mg/L 1.65767824497258 -DTXSID3027328 Css 3compartmentss Human 95% 9.153 mg/L 5.601 mg/L 1.63417246920193 -DTXSID3027401 Css 3compartmentss Human 95% 2.011 mg/L 0.9016 mg/L 2.23047914818101 -DTXSID3027403 Css 3compartmentss Human 95% 0.5061 mg/L 0.115 mg/L 4.40086956521739 -DTXSID3027407 Css 3compartmentss Human 95% 7.079 mg/L 4.52 mg/L 1.56615044247788 -DTXSID3027530 Css 3compartmentss Human 95% 103.6 mg/L 35.53 mg/L 2.91584576414298 -DTXSID3027534 Css 3compartmentss Human 95% 5.091 mg/L 3.626 mg/L 1.40402647545505 -DTXSID3027536 Css 3compartmentss Human 95% 0.5549 mg/L 0 mg/L Inf -DTXSID3027580 Css 3compartmentss Human 95% 2.39 mg/L 1e-09 mg/L 2.39e+09 -DTXSID3027584 Css 3compartmentss Human 95% 5.512 mg/L 0.1982 mg/L 27.8102926337033 -DTXSID3027588 Css 3compartmentss Human 95% 14.68 mg/L 17.46 mg/L 0.84077892325315 -DTXSID3027615 Css 3compartmentss Human 95% 0.826 mg/L 0.4404 mg/L 1.8755676657584 -DTXSID3027617 Css 3compartmentss Human 95% 8.228 mg/L 5.204 mg/L 1.58109146810146 -DTXSID3027740 Css 3compartmentss Human 95% 0.4694 mg/L 0.2888 mg/L 1.62534626038781 -DTXSID3027790 Css 3compartmentss Human 95% 0.4458 mg/L 0.2853 mg/L 1.56256572029443 -DTXSID3027792 Css 3compartmentss Human 95% 7.182 mg/L 5.109 mg/L 1.40575455079272 -DTXSID3027798 Css 3compartmentss Human 95% 3.207 mg/L 2.213 mg/L 1.44916403072752 -DTXSID3027823 Css 3compartmentss Human 95% 3.345 mg/L 1.598 mg/L 2.09324155193992 -DTXSID3027829 Css 3compartmentss Human 95% 6.554 mg/L 4.15 mg/L 1.57927710843373 -DTXSID3027875 Css 3compartmentss Human 95% 10620 mg/L 9425 mg/L 1.12679045092838 -DTXSID3027877 Css 3compartmentss Human 95% 0.01019 mg/L 0 mg/L Inf -DTXSID3027902 Css 3compartmentss Human 95% 223 mg/L 108.4 mg/L 2.05719557195572 -DTXSID3028001 Css 3compartmentss Human 95% 3.032 mg/L 0.1078 mg/L 28.126159554731 -DTXSID3029150 Css 3compartmentss Human 95% 2.089 mg/L 1.538 mg/L 1.35825747724317 -DTXSID3029152 Css 3compartmentss Human 95% 0.5607 mg/L 0.399 mg/L 1.40526315789474 -DTXSID3029154 Css 3compartmentss Human 95% 3.176 mg/L 2.392 mg/L 1.32775919732441 -DTXSID3029158 Css 3compartmentss Human 95% 4.327 mg/L 3.104 mg/L 1.39400773195876 -DTXSID3029231 Css 3compartmentss Human 95% 2.939 mg/L 3.182 mg/L 0.923632935260842 -DTXSID3029233 Css 3compartmentss Human 95% 44.43 mg/L 26.9 mg/L 1.65167286245353 -DTXSID3029237 Css 3compartmentss Human 95% 1.055 mg/L 0.6443 mg/L 1.63743597702933 -DTXSID3029283 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID3029287 Css 3compartmentss Human 95% 5.706 mg/L 3.436 mg/L 1.66065192083818 -DTXSID3029289 Css 3compartmentss Human 95% 5.258 mg/L 3.718 mg/L 1.41420118343195 -DTXSID3029312 Css 3compartmentss Human 95% 70.98 mg/L 38.9 mg/L 1.82467866323907 -DTXSID3029362 Css 3compartmentss Human 95% 0.09223 mg/L 0.001548 mg/L 59.5801033591731 -DTXSID3029364 Css 3compartmentss Human 95% 2.026 mg/L 1.15 mg/L 1.76173913043478 -DTXSID3029572 Css 3compartmentss Human 95% 2.731 mg/L 1.607 mg/L 1.6994399502178 -DTXSID3029607 Css 3compartmentss Human 95% 1.368 mg/L 0.9243 mg/L 1.48003894839338 -DTXSID3029651 Css 3compartmentss Human 95% 8.572 mg/L 5.418 mg/L 1.58213362864526 -DTXSID3029653 Css 3compartmentss Human 95% 11.09 mg/L 6.759 mg/L 1.64077526261281 -DTXSID3029655 Css 3compartmentss Human 95% 6.553 mg/L 4.596 mg/L 1.42580504786771 -DTXSID3029815 Css 3compartmentss Human 95% 0.04751 mg/L 0.0006844 mg/L 69.4184687317358 -DTXSID3029869 Css 3compartmentss Human 95% 17.4 mg/L 8.525 mg/L 2.04105571847507 -DTXSID3030189 Css 3compartmentss Human 95% 18.43 mg/L 10.65 mg/L 1.73051643192488 -DTXSID3030428 Css 3compartmentss Human 95% 1.011 mg/L 0.6287 mg/L 1.60808016542071 -DTXSID3030636 Css 3compartmentss Human 95% 14.38 mg/L 9.281 mg/L 1.54940200409439 -DTXSID3031444 Css 3compartmentss Human 95% 8.81 mg/L 5.575 mg/L 1.58026905829596 -DTXSID3031521 Css 3compartmentss Human 95% 5.609 mg/L 3.466 mg/L 1.61829197922677 -DTXSID3031860 Css 3compartmentss Human 95% 677.2 mg/L 386.6 mg/L 1.75168132436627 -DTXSID3031862 Css 3compartmentss Human 95% 398.6 mg/L 231.7 mg/L 1.72032801035822 -DTXSID3031864 Css 3compartmentss Human 95% 1391 mg/L 798.9 mg/L 1.74114407310051 -DTXSID3032337 Css 3compartmentss Human 95% 10.27 mg/L 0.4643 mg/L 22.1193194055568 -DTXSID3032389 Css 3compartmentss Human 95% 3.134 mg/L 0.1492 mg/L 21.0053619302949 -DTXSID3032416 Css 3compartmentss Human 95% 3.137 mg/L 1.751 mg/L 1.79154768703598 -DTXSID3032464 Css 3compartmentss Human 95% 2.493 mg/L 0.8198 mg/L 3.04098560624543 -DTXSID3032541 Css 3compartmentss Human 95% 21.6 mg/L 16.12 mg/L 1.33995037220844 -DTXSID3032547 Css 3compartmentss Human 95% 0.7711 mg/L 0.4281 mg/L 1.80121466946975 -DTXSID3032549 Css 3compartmentss Human 95% 2.837 mg/L 1.363 mg/L 2.08143800440205 -DTXSID3032620 Css 3compartmentss Human 95% 33.42 mg/L 0.0671 mg/L 498.06259314456 -DTXSID3032622 Css 3compartmentss Human 95% 4.245 mg/L 1.493 mg/L 2.84326858673811 -DTXSID3032626 Css 3compartmentss Human 95% 0.5162 mg/L 0.2676 mg/L 1.92899850523169 -DTXSID3032628 Css 3compartmentss Human 95% 6.542 mg/L 3.415 mg/L 1.91566617862372 -DTXSID3032670 Css 3compartmentss Human 95% 46.73 mg/L 25.94 mg/L 1.80146491904395 -DTXSID3032751 Css 3compartmentss Human 95% 2 mg/L 1.34 mg/L 1.49253731343284 -DTXSID3032759 Css 3compartmentss Human 95% 3.939 mg/L 2.264 mg/L 1.73984098939929 -DTXSID3032832 Css 3compartmentss Human 95% 7.324 mg/L 4.867 mg/L 1.50482843640847 -DTXSID3033276 Css 3compartmentss Human 95% 7.108 mg/L 4.885 mg/L 1.45506653019447 -DTXSID3033307 Css 3compartmentss Human 95% 0.03054 mg/L 0 mg/L Inf -DTXSID3033511 Css 3compartmentss Human 95% 8.141 mg/L 5.03 mg/L 1.61848906560636 -DTXSID3033519 Css 3compartmentss Human 95% 5.615 mg/L 3.592 mg/L 1.56319599109131 -DTXSID3033983 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID3033989 Css 3compartmentss Human 95% 330.7 mg/L 185.5 mg/L 1.78274932614555 -DTXSID3034113 Css 3compartmentss Human 95% 10.45 mg/L 8.192 mg/L 1.275634765625 -DTXSID3034165 Css 3compartmentss Human 95% 13.6 mg/L 9.009 mg/L 1.50960150960151 -DTXSID3034402 Css 3compartmentss Human 95% 2.833 mg/L 0.322 mg/L 8.79813664596273 -DTXSID3034456 Css 3compartmentss Human 95% 9.886 mg/L 0.923 mg/L 10.7107258938245 -DTXSID3034458 Css 3compartmentss Human 95% 29.41 mg/L 11.67 mg/L 2.52013710368466 -DTXSID3034531 Css 3compartmentss Human 95% 0.4911 mg/L 0.2711 mg/L 1.81150866838805 -DTXSID3034583 Css 3compartmentss Human 95% 5.452 mg/L 2.68 mg/L 2.03432835820896 -DTXSID3034612 Css 3compartmentss Human 95% 1.326 mg/L 0.224 mg/L 5.91964285714286 -DTXSID3034614 Css 3compartmentss Human 95% 19.7 mg/L 11.1 mg/L 1.77477477477477 -DTXSID3034618 Css 3compartmentss Human 95% 0.06329 mg/L 0.0337 mg/L 1.87804154302671 -DTXSID3034662 Css 3compartmentss Human 95% 7.861 mg/L 2.595 mg/L 3.02928709055877 -DTXSID3034664 Css 3compartmentss Human 95% 7.361 mg/L 4.734 mg/L 1.55492184199409 -DTXSID3034872 Css 3compartmentss Human 95% 7.301 mg/L 5 mg/L 1.4602 -DTXSID3034903 Css 3compartmentss Human 95% 11.05 mg/L 6.749 mg/L 1.63727959697733 -DTXSID3034957 Css 3compartmentss Human 95% 5.491 mg/L 3.335 mg/L 1.64647676161919 -DTXSID3035214 Css 3compartmentss Human 95% 10.2 mg/L 9.412 mg/L 1.08372290692733 -DTXSID3035266 Css 3compartmentss Human 95% 139.4 mg/L 0.005819 mg/L 23956.00618663 -DTXSID3036286 Css 3compartmentss Human 95% 1.477 mg/L 1.006 mg/L 1.46819085487078 -DTXSID3036288 Css 3compartmentss Human 95% 0.2921 mg/L 0 mg/L Inf -DTXSID3036496 Css 3compartmentss Human 95% 9.807 mg/L 4.677 mg/L 2.09685695958948 -DTXSID3036525 Css 3compartmentss Human 95% 11 mg/L 6.683 mg/L 1.6459673799192 -DTXSID3036999 Css 3compartmentss Human 95% 8.049 mg/L 4.983 mg/L 1.61529199277544 -DTXSID3037044 Css 3compartmentss Human 95% 0.61 mg/L 0.4117 mg/L 1.4816614039349 -DTXSID3037094 Css 3compartmentss Human 95% 3.584 mg/L 0.1478 mg/L 24.2489851150203 -DTXSID3037208 Css 3compartmentss Human 95% 30.97 mg/L 15.36 mg/L 2.01627604166667 -DTXSID3037250 Css 3compartmentss Human 95% 59.33 mg/L 28.05 mg/L 2.11515151515152 -DTXSID3037541 Css 3compartmentss Human 95% 95.94 mg/L 43.59 mg/L 2.20096352374398 -DTXSID3037545 Css 3compartmentss Human 95% 0.688 mg/L 0.3677 mg/L 1.87109056295893 -DTXSID3037626 Css 3compartmentss Human 95% 165.3 mg/L 59.01 mg/L 2.80122013218099 -DTXSID3037672 Css 3compartmentss Human 95% 8.007 mg/L 5.005 mg/L 1.5998001998002 -DTXSID3037707 Css 3compartmentss Human 95% 352.7 mg/L 204.8 mg/L 1.72216796875 -DTXSID3037709 Css 3compartmentss Human 95% 4054 mg/L 2350 mg/L 1.72510638297872 -DTXSID3038694 Css 3compartmentss Human 95% 2.875 mg/L 1.852 mg/L 1.55237580993521 -DTXSID3038696 Css 3compartmentss Human 95% 0.4948 mg/L 0.4309 mg/L 1.14829426781156 -DTXSID3038800 Css 3compartmentss Human 95% 0.335 mg/L 0.2041 mg/L 1.64135227829495 -DTXSID3038852 Css 3compartmentss Human 95% 50.66 mg/L 28.35 mg/L 1.78694885361552 -DTXSID3038939 Css 3compartmentss Human 95% 138.7 mg/L 11.05 mg/L 12.552036199095 -DTXSID3039240 Css 3compartmentss Human 95% 3.278 mg/L 2.285 mg/L 1.43457330415755 -DTXSID3040279 Css 3compartmentss Human 95% 18.89 mg/L 0.001128 mg/L 16746.4539007092 -DTXSID3040352 Css 3compartmentss Human 95% 5.105 mg/L 2.987 mg/L 1.70907264814195 -DTXSID3040643 Css 3compartmentss Human 95% 0.5007 mg/L 0.4163 mg/L 1.20273840980062 -DTXSID3040647 Css 3compartmentss Human 95% 0.2552 mg/L 0.1539 mg/L 1.6582196231319 -DTXSID3040691 Css 3compartmentss Human 95% 6.557 mg/L 5.396 mg/L 1.21515937731653 -DTXSID3040699 Css 3compartmentss Human 95% 1096 mg/L 685.7 mg/L 1.59836663263818 -DTXSID3040720 Css 3compartmentss Human 95% 15.59 mg/L 8.927 mg/L 1.74638736417609 -DTXSID3040722 Css 3compartmentss Human 95% 124.3 mg/L 251.2 mg/L 0.494824840764331 -DTXSID3040724 Css 3compartmentss Human 95% 0.304 mg/L 0.2219 mg/L 1.36998648039658 -DTXSID3040726 Css 3compartmentss Human 95% 0.9342 mg/L 0.4158 mg/L 2.24675324675325 -DTXSID3040728 Css 3compartmentss Human 95% 0.5049 mg/L 0.3103 mg/L 1.62713503061553 -DTXSID3040770 Css 3compartmentss Human 95% 6.778 mg/L 0.183 mg/L 37.0382513661202 -DTXSID3040776 Css 3compartmentss Human 95% 945.8 mg/L 549.7 mg/L 1.72057485901401 -DTXSID3040801 Css 3compartmentss Human 95% 40.27 mg/L 9.738 mg/L 4.1353460669542 -DTXSID3040980 Css 3compartmentss Human 95% 2.292 mg/L 1.648 mg/L 1.39077669902913 -DTXSID3041035 Css 3compartmentss Human 95% 0.3749 mg/L 0.1676 mg/L 2.23687350835322 -DTXSID3041085 Css 3compartmentss Human 95% 0.7228 mg/L 0.5071 mg/L 1.42535988956813 -DTXSID3041247 Css 3compartmentss Human 95% 7.307 mg/L 5.038 mg/L 1.45037713378325 -DTXSID3041293 Css 3compartmentss Human 95% 0.2079 mg/L 0.1593 mg/L 1.30508474576271 -DTXSID3041299 Css 3compartmentss Human 95% 51.89 mg/L 67.27 mg/L 0.771369109558496 -DTXSID3041328 Css 3compartmentss Human 95% 69.36 mg/L 5.813 mg/L 11.9318768277998 -DTXSID3041370 Css 3compartmentss Human 95% 2.896 mg/L 2.025 mg/L 1.43012345679012 -DTXSID3041372 Css 3compartmentss Human 95% 162.2 mg/L 95.4 mg/L 1.70020964360587 -DTXSID3041376 Css 3compartmentss Human 95% 20.3 mg/L 0.061 mg/L 332.786885245902 -DTXSID3041403 Css 3compartmentss Human 95% 0.05583 mg/L 0.04897 mg/L 1.140085766796 -DTXSID3041405 Css 3compartmentss Human 95% 8.964 mg/L 5.606 mg/L 1.59900107028184 -DTXSID3041409 Css 3compartmentss Human 95% 0.1809 mg/L 0.1216 mg/L 1.48766447368421 -DTXSID3041451 Css 3compartmentss Human 95% 6.286 mg/L 3.531 mg/L 1.78023222883036 -DTXSID3041530 Css 3compartmentss Human 95% 9.3 mg/L 4.167 mg/L 2.23182145428366 -DTXSID3041580 Css 3compartmentss Human 95% 5.697 mg/L 3.108 mg/L 1.83301158301158 -DTXSID3041611 Css 3compartmentss Human 95% 291.7 mg/L 178.2 mg/L 1.63692480359147 -DTXSID3041613 Css 3compartmentss Human 95% 5.369 mg/L 2.806 mg/L 1.91339985744832 -DTXSID3041615 Css 3compartmentss Human 95% 2.251 mg/L 1.531 mg/L 1.47028086218158 -DTXSID3041617 Css 3compartmentss Human 95% 3.554 mg/L 1.845 mg/L 1.92628726287263 -DTXSID3041619 Css 3compartmentss Human 95% 15.64 mg/L 6.548 mg/L 2.3885155772755 -DTXSID3041661 Css 3compartmentss Human 95% 8.369 mg/L 5.167 mg/L 1.6197019547126 -DTXSID3041663 Css 3compartmentss Human 95% 12.73 mg/L 4.661 mg/L 2.73117356790388 -DTXSID3041665 Css 3compartmentss Human 95% 0.4072 mg/L 0.0004278 mg/L 951.846657316503 -DTXSID3041744 Css 3compartmentss Human 95% 29.75 mg/L 0.3585 mg/L 82.9846582984658 -DTXSID3041794 Css 3compartmentss Human 95% 29.49 mg/L 0.3093 mg/L 95.3443258971872 -DTXSID3041827 Css 3compartmentss Human 95% 32.17 mg/L 23.74 mg/L 1.35509688289806 -DTXSID3041873 Css 3compartmentss Human 95% 4.124 mg/L 1.929 mg/L 2.13789528252981 -DTXSID3042007 Css 3compartmentss Human 95% 354.9 mg/L 731.7 mg/L 0.485034850348503 -DTXSID3042051 Css 3compartmentss Human 95% 0.8246 mg/L 0.7575 mg/L 1.08858085808581 -DTXSID3042053 Css 3compartmentss Human 95% 29.63 mg/L 16.89 mg/L 1.75429248075784 -DTXSID3042130 Css 3compartmentss Human 95% 31.47 mg/L 0.09784 mg/L 321.64758789861 -DTXSID3042180 Css 3compartmentss Human 95% 1.774 mg/L 1.029 mg/L 1.72400388726919 -DTXSID3042188 Css 3compartmentss Human 95% 0.3909 mg/L 0.2694 mg/L 1.45100222717149 -DTXSID3042261 Css 3compartmentss Human 95% 21.84 mg/L 1.235 mg/L 17.6842105263158 -DTXSID3042269 Css 3compartmentss Human 95% 5.941 mg/L 0.03552 mg/L 167.257882882883 -DTXSID3042390 Css 3compartmentss Human 95% 8.108 mg/L 5.12 mg/L 1.58359375 -DTXSID3042394 Css 3compartmentss Human 95% 23.46 mg/L 12.56 mg/L 1.86783439490446 -DTXSID3042423 Css 3compartmentss Human 95% 0.04293 mg/L 0.02873 mg/L 1.49425687434737 -DTXSID3042477 Css 3compartmentss Human 95% 2.766 mg/L 0.9795 mg/L 2.82388973966309 -DTXSID3042500 Css 3compartmentss Human 95% 5.079 mg/L 2.351e-05 mg/L 216035.729476818 -DTXSID3042508 Css 3compartmentss Human 95% 7.718 mg/L 4.728 mg/L 1.6324027072758 -DTXSID3042633 Css 3compartmentss Human 95% 1177 mg/L 772.4 mg/L 1.52382185396168 -DTXSID3042681 Css 3compartmentss Human 95% 1.411 mg/L 0.911 mg/L 1.54884742041712 -DTXSID3043734 Css 3compartmentss Human 95% 5.729 mg/L 3.628 mg/L 1.57910694597574 -DTXSID3043782 Css 3compartmentss Human 95% 40.46 mg/L 21.47 mg/L 1.88448998602701 -DTXSID3044124 Css 3compartmentss Human 95% 0.8651 mg/L 0.4426 mg/L 1.95458653411658 -DTXSID3044128 Css 3compartmentss Human 95% 11.11 mg/L 2.19 mg/L 5.07305936073059 -DTXSID3044201 Css 3compartmentss Human 95% 0.7799 mg/L 0.4339 mg/L 1.79741876008297 -DTXSID3044203 Css 3compartmentss Human 95% 27.79 mg/L 13.86 mg/L 2.00505050505051 -DTXSID3044205 Css 3compartmentss Human 95% 1.059 mg/L 0.5934 mg/L 1.78463094034378 -DTXSID3044251 Css 3compartmentss Human 95% 0.3692 mg/L 0.2376 mg/L 1.55387205387205 -DTXSID3044338 Css 3compartmentss Human 95% 2.868 mg/L 1.571 mg/L 1.82558879694462 -DTXSID3044380 Css 3compartmentss Human 95% 8.334 mg/L 5.37 mg/L 1.55195530726257 -DTXSID3044382 Css 3compartmentss Human 95% 0.9929 mg/L 0.684 mg/L 1.4516081871345 -DTXSID3044388 Css 3compartmentss Human 95% 6.912 mg/L 4.83 mg/L 1.43105590062112 -DTXSID3044411 Css 3compartmentss Human 95% 0.4458 mg/L 0.3055 mg/L 1.45924713584288 -DTXSID3044413 Css 3compartmentss Human 95% 5.388 mg/L 1.848 mg/L 2.91558441558442 -DTXSID3044415 Css 3compartmentss Human 95% 0.6299 mg/L 0.3958 mg/L 1.59146033350177 -DTXSID3044461 Css 3compartmentss Human 95% 6.671 mg/L 7.289 mg/L 0.91521470709288 -DTXSID3044465 Css 3compartmentss Human 95% 0.2973 mg/L 6.529e-06 mg/L 45535.304028182 -DTXSID3044469 Css 3compartmentss Human 95% 5.512 mg/L 3.307 mg/L 1.66676746295736 -DTXSID3044542 Css 3compartmentss Human 95% 0.414 mg/L 0.2702 mg/L 1.53219837157661 -DTXSID3044544 Css 3compartmentss Human 95% 19.47 mg/L 7.079 mg/L 2.75038847294816 -DTXSID3044590 Css 3compartmentss Human 95% 1147 mg/L 674.7 mg/L 1.7000148214021 -DTXSID3044598 Css 3compartmentss Human 95% 5.267 mg/L 3.573 mg/L 1.47411139098797 -DTXSID3044621 Css 3compartmentss Human 95% 0.002769 mg/L 0.0006104 mg/L 4.53636959370904 -DTXSID3044623 Css 3compartmentss Human 95% 5.852 mg/L 3.925 mg/L 1.49095541401274 -DTXSID3044625 Css 3compartmentss Human 95% 5.544 mg/L 3.776 mg/L 1.46822033898305 -DTXSID3044627 Css 3compartmentss Human 95% 14.73 mg/L 8.743 mg/L 1.68477639254261 -DTXSID3044629 Css 3compartmentss Human 95% 8.169 mg/L 5.158 mg/L 1.5837533927879 -DTXSID3044679 Css 3compartmentss Human 95% 3.289 mg/L 2.04 mg/L 1.61225490196078 -DTXSID3044702 Css 3compartmentss Human 95% 4.065 mg/L 2.101 mg/L 1.93479295573536 -DTXSID3044704 Css 3compartmentss Human 95% 1212 mg/L 700.2 mg/L 1.73093401885176 -DTXSID3044706 Css 3compartmentss Human 95% 3.643 mg/L 1.626 mg/L 2.24046740467405 -DTXSID3044750 Css 3compartmentss Human 95% 0.5633 mg/L 0.3809 mg/L 1.47886584405356 -DTXSID3044752 Css 3compartmentss Human 95% 3.602 mg/L 2.409 mg/L 1.49522623495226 -DTXSID3044758 Css 3compartmentss Human 95% 237.3 mg/L 94.74 mg/L 2.50474984167194 -DTXSID3044831 Css 3compartmentss Human 95% 0.1765 mg/L 0.09941 mg/L 1.77547530429534 -DTXSID3044835 Css 3compartmentss Human 95% 32.45 mg/L 11.15 mg/L 2.91031390134529 -DTXSID3044837 Css 3compartmentss Human 95% 0.8589 mg/L 0.6265 mg/L 1.37094972067039 -DTXSID3044881 Css 3compartmentss Human 95% 0.01487 mg/L 0.00931 mg/L 1.59720730397422 -DTXSID3044883 Css 3compartmentss Human 95% 6.753 mg/L 4.15 mg/L 1.62722891566265 -DTXSID3044887 Css 3compartmentss Human 95% 43.96 mg/L 19.33 mg/L 2.27418520434558 -DTXSID3044910 Css 3compartmentss Human 95% 4.889 mg/L 3.234 mg/L 1.5117501546073 -DTXSID3044914 Css 3compartmentss Human 95% 67.82 mg/L 37.08 mg/L 1.82901833872708 -DTXSID3044916 Css 3compartmentss Human 95% 7.125 mg/L 4.602 mg/L 1.54823989569752 -DTXSID3044960 Css 3compartmentss Human 95% 5.225 mg/L 2.96 mg/L 1.7652027027027 -DTXSID3044962 Css 3compartmentss Human 95% 11.21 mg/L 7.318 mg/L 1.53183930035529 -DTXSID3044966 Css 3compartmentss Human 95% 20.66 mg/L 0.5299 mg/L 38.9884883940366 -DTXSID3045140 Css 3compartmentss Human 95% 100.1 mg/L 99.89 mg/L 1.0021023125438 -DTXSID3045144 Css 3compartmentss Human 95% 33.69 mg/L 9.83e-05 mg/L 342726.347914547 -DTXSID3045190 Css 3compartmentss Human 95% 0.624 mg/L 0.4646 mg/L 1.34309083082221 -DTXSID3045192 Css 3compartmentss Human 95% 11.78 mg/L 8.298 mg/L 1.41961918534587 -DTXSID3045194 Css 3compartmentss Human 95% 0.0548 mg/L 0.04518 mg/L 1.21292607348384 -DTXSID3045196 Css 3compartmentss Human 95% 0.5804 mg/L 0.537 mg/L 1.08081936685289 -DTXSID3045198 Css 3compartmentss Human 95% 1.225 mg/L 0.7574 mg/L 1.6173752310536 -DTXSID3045221 Css 3compartmentss Human 95% 0.4849 mg/L 0.3536 mg/L 1.37132352941176 -DTXSID3045223 Css 3compartmentss Human 95% 0.6392 mg/L 0.2156 mg/L 2.96474953617811 -DTXSID3045225 Css 3compartmentss Human 95% 8.802 mg/L 5.417 mg/L 1.62488462248477 -DTXSID3045227 Css 3compartmentss Human 95% 5.86 mg/L 2.035 mg/L 2.87960687960688 -DTXSID3045271 Css 3compartmentss Human 95% 0.2239 mg/L 0.04362 mg/L 5.13296652911508 -DTXSID3045300 Css 3compartmentss Human 95% 0.5176 mg/L 0.2209 mg/L 2.34314169307379 -DTXSID3045304 Css 3compartmentss Human 95% 1.495 mg/L 0.65 mg/L 2.3 -DTXSID3045306 Css 3compartmentss Human 95% 3.191 mg/L 2.586 mg/L 1.23395204949729 -DTXSID3045350 Css 3compartmentss Human 95% 5.135 mg/L 3.271 mg/L 1.56985631305411 -DTXSID3045352 Css 3compartmentss Human 95% 0.002732 mg/L 0.0003487 mg/L 7.83481502724405 -DTXSID3045354 Css 3compartmentss Human 95% 11 mg/L 9.016 mg/L 1.22005323868678 -DTXSID3045356 Css 3compartmentss Human 95% 2.638 mg/L 1.11 mg/L 2.37657657657658 -DTXSID3045433 Css 3compartmentss Human 95% 3.46 mg/L 1.873 mg/L 1.84730379071009 -DTXSID3045435 Css 3compartmentss Human 95% 6.195 mg/L 1.063 mg/L 5.82784571966134 -DTXSID3045437 Css 3compartmentss Human 95% 4.29 mg/L 3.194 mg/L 1.34314339386349 -DTXSID3045439 Css 3compartmentss Human 95% 1.044 mg/L 0.936 mg/L 1.11538461538462 -DTXSID3045485 Css 3compartmentss Human 95% 0.5468 mg/L 0.3201 mg/L 1.70821618244299 -DTXSID3045514 Css 3compartmentss Human 95% 0.4585 mg/L 0.2659 mg/L 1.72433245581045 -DTXSID3045560 Css 3compartmentss Human 95% 28.81 mg/L 2.59 mg/L 11.1235521235521 -DTXSID3045562 Css 3compartmentss Human 95% 0.4452 mg/L 0.005334 mg/L 83.4645669291339 -DTXSID3045566 Css 3compartmentss Human 95% 9.974 mg/L 3.329 mg/L 2.99609492340042 -DTXSID3045568 Css 3compartmentss Human 95% 26.45 mg/L 2.414 mg/L 10.956917978459 -DTXSID3045645 Css 3compartmentss Human 95% 5.869 mg/L 3.184 mg/L 1.84327889447236 -DTXSID3045647 Css 3compartmentss Human 95% 4.482 mg/L 2.537 mg/L 1.76665352778873 -DTXSID3045649 Css 3compartmentss Human 95% 5.253 mg/L 3.39 mg/L 1.54955752212389 -DTXSID3045691 Css 3compartmentss Human 95% 10.75 mg/L 7.062 mg/L 1.52223166241858 -DTXSID3045693 Css 3compartmentss Human 95% 560.6 mg/L 323.5 mg/L 1.73292117465224 -DTXSID3045695 Css 3compartmentss Human 95% 2.702 mg/L 1.5 mg/L 1.80133333333333 -DTXSID3045697 Css 3compartmentss Human 95% 4.175 mg/L 2.431 mg/L 1.71740024681201 -DTXSID3045699 Css 3compartmentss Human 95% 5.727 mg/L 3.404 mg/L 1.68243243243243 -DTXSID3045770 Css 3compartmentss Human 95% 0.9227 mg/L 0.6181 mg/L 1.49280051771558 -DTXSID3045772 Css 3compartmentss Human 95% 0.09676 mg/L 0.1397 mg/L 0.692627057981389 -DTXSID3045774 Css 3compartmentss Human 95% 1.233 mg/L 0.5002 mg/L 2.46501399440224 -DTXSID3045776 Css 3compartmentss Human 95% 1.654 mg/L 1.169 mg/L 1.41488451668092 -DTXSID3045803 Css 3compartmentss Human 95% 0.7509 mg/L 0.3058 mg/L 2.45552648790059 -DTXSID3045805 Css 3compartmentss Human 95% 0.1434 mg/L 0.09892 mg/L 1.44965628790942 -DTXSID3045807 Css 3compartmentss Human 95% 0.3521 mg/L 0.2353 mg/L 1.49638759031024 -DTXSID3045809 Css 3compartmentss Human 95% 3.998 mg/L 2.198 mg/L 1.8189262966333 -DTXSID3045851 Css 3compartmentss Human 95% 4.863 mg/L 2.881 mg/L 1.6879555709823 -DTXSID3045855 Css 3compartmentss Human 95% 5.625 mg/L 3.628 mg/L 1.55044101433297 -DTXSID3045857 Css 3compartmentss Human 95% 1.776 mg/L 1.042 mg/L 1.70441458733205 -DTXSID3045859 Css 3compartmentss Human 95% 1.685 mg/L 0.7182 mg/L 2.34614313561682 -DTXSID3045930 Css 3compartmentss Human 95% 6.5 mg/L 3.695 mg/L 1.75913396481732 -DTXSID3045934 Css 3compartmentss Human 95% 1.272 mg/L 0.8115 mg/L 1.56746765249538 -DTXSID3045938 Css 3compartmentss Human 95% 0.03187 mg/L 0.0223 mg/L 1.42914798206278 -DTXSID3045980 Css 3compartmentss Human 95% 0.6692 mg/L 0.4695 mg/L 1.42534611288605 -DTXSID3045984 Css 3compartmentss Human 95% 5.281 mg/L 3.388 mg/L 1.55873671782763 -DTXSID3045988 Css 3compartmentss Human 95% 17.87 mg/L 25.7 mg/L 0.695330739299611 -DTXSID3046083 Css 3compartmentss Human 95% 16.62 mg/L 0.1378 mg/L 120.609579100145 -DTXSID3046085 Css 3compartmentss Human 95% 7.638 mg/L 4.968 mg/L 1.53743961352657 -DTXSID3046110 Css 3compartmentss Human 95% 0.3737 mg/L 0.2123 mg/L 1.76024493641074 -DTXSID3046112 Css 3compartmentss Human 95% 2.41 mg/L 1.748 mg/L 1.37871853546911 -DTXSID3046114 Css 3compartmentss Human 95% 2.862 mg/L 2.41 mg/L 1.18755186721992 -DTXSID3046116 Css 3compartmentss Human 95% 9.614 mg/L 5.118 mg/L 1.87846815162173 -DTXSID3046118 Css 3compartmentss Human 95% 24.85 mg/L 13.29 mg/L 1.86982693754703 -DTXSID3046160 Css 3compartmentss Human 95% 8.917 mg/L 3.341 mg/L 2.66896138880575 -DTXSID3046162 Css 3compartmentss Human 95% 1.276 mg/L 0.7797 mg/L 1.63652686930871 -DTXSID3046164 Css 3compartmentss Human 95% 4.182 mg/L 2.606 mg/L 1.60475825019187 -DTXSID3046166 Css 3compartmentss Human 95% 0.08147 mg/L 0.06477 mg/L 1.25783541763162 -DTXSID3046241 Css 3compartmentss Human 95% 0.02901 mg/L 3.344e-05 mg/L 867.523923444976 -DTXSID3046245 Css 3compartmentss Human 95% 3.108 mg/L 1.873 mg/L 1.65936999466097 -DTXSID3046247 Css 3compartmentss Human 95% 2.373 mg/L 1.209 mg/L 1.96277915632754 -DTXSID3046249 Css 3compartmentss Human 95% 13.44 mg/L 7.022 mg/L 1.91398461976645 -DTXSID3046291 Css 3compartmentss Human 95% 17.75 mg/L 9.747 mg/L 1.82107315071304 -DTXSID3046295 Css 3compartmentss Human 95% 1.239 mg/L 0.6014 mg/L 2.06019288327236 -DTXSID3046297 Css 3compartmentss Human 95% 13.85 mg/L 7.552 mg/L 1.83395127118644 -DTXSID3046299 Css 3compartmentss Human 95% 0.2988 mg/L 0.2498 mg/L 1.19615692554043 -DTXSID3046320 Css 3compartmentss Human 95% 6.083 mg/L 3.283 mg/L 1.85287846481876 -DTXSID3046322 Css 3compartmentss Human 95% 1.286 mg/L 0.7319 mg/L 1.75707063806531 -DTXSID3046324 Css 3compartmentss Human 95% 9.52 mg/L 5.485 mg/L 1.73564266180492 -DTXSID3046326 Css 3compartmentss Human 95% 1.642 mg/L 0.9938 mg/L 1.65224391225599 -DTXSID3046401 Css 3compartmentss Human 95% 2.827 mg/L 2.105 mg/L 1.34299287410926 -DTXSID3046403 Css 3compartmentss Human 95% 5.45 mg/L 3.327 mg/L 1.63811241358581 -DTXSID3046405 Css 3compartmentss Human 95% 0.02507 mg/L 0.01364 mg/L 1.83797653958944 -DTXSID3046407 Css 3compartmentss Human 95% 0.5776 mg/L 0.4144 mg/L 1.39382239382239 -DTXSID3046409 Css 3compartmentss Human 95% 0.6994 mg/L 0.3882 mg/L 1.80164863472437 -DTXSID3046451 Css 3compartmentss Human 95% 0.282 mg/L 0.1569 mg/L 1.79732313575526 -DTXSID3046453 Css 3compartmentss Human 95% 22.27 mg/L 3.2 mg/L 6.959375 -DTXSID3046455 Css 3compartmentss Human 95% 0.2771 mg/L 0.2254 mg/L 1.22937000887311 -DTXSID3046457 Css 3compartmentss Human 95% 6.224 mg/L 3.229 mg/L 1.92753174357386 -DTXSID3046459 Css 3compartmentss Human 95% 13.24 mg/L 14.68 mg/L 0.901907356948229 -DTXSID3046530 Css 3compartmentss Human 95% 5.532 mg/L 3.307 mg/L 1.67281524039915 -DTXSID3046532 Css 3compartmentss Human 95% 17.36 mg/L 13.63 mg/L 1.27366104181952 -DTXSID3046534 Css 3compartmentss Human 95% 4.202 mg/L 1.99 mg/L 2.11155778894472 -DTXSID3046536 Css 3compartmentss Human 95% 5.81 mg/L 3.651 mg/L 1.59134483703095 -DTXSID3046580 Css 3compartmentss Human 95% 1.787 mg/L 0.8435 mg/L 2.1185536455246 -DTXSID3046584 Css 3compartmentss Human 95% 5.303 mg/L 3.216 mg/L 1.64894278606965 -DTXSID3046586 Css 3compartmentss Human 95% 2.421 mg/L 1.528 mg/L 1.58442408376963 -DTXSID3046588 Css 3compartmentss Human 95% 32.68 mg/L 19.62 mg/L 1.66564729867482 -DTXSID3046615 Css 3compartmentss Human 95% 2.425 mg/L 1.735 mg/L 1.39769452449568 -DTXSID3046617 Css 3compartmentss Human 95% 62.77 mg/L 37.98 mg/L 1.65271195365982 -DTXSID3046619 Css 3compartmentss Human 95% 19.11 mg/L 5.815 mg/L 3.28632846087704 -DTXSID3046663 Css 3compartmentss Human 95% 0.28 mg/L 0 mg/L Inf -DTXSID3046665 Css 3compartmentss Human 95% 2.703 mg/L 0.03184 mg/L 84.893216080402 -DTXSID3046740 Css 3compartmentss Human 95% 22.13 mg/L 7.293 mg/L 3.03441656382833 -DTXSID3046742 Css 3compartmentss Human 95% 0.2069 mg/L 0.09532 mg/L 2.17058329836341 -DTXSID3046744 Css 3compartmentss Human 95% 8.312 mg/L 4.169 mg/L 1.99376349244423 -DTXSID3046748 Css 3compartmentss Human 95% 6.403 mg/L 3.948 mg/L 1.62183383991895 -DTXSID3046790 Css 3compartmentss Human 95% 1.076 mg/L 0.5847 mg/L 1.84025996237387 -DTXSID3046792 Css 3compartmentss Human 95% 2.376 mg/L 0.04016 mg/L 59.1633466135458 -DTXSID3046796 Css 3compartmentss Human 95% 12.54 mg/L 6.665 mg/L 1.8814703675919 -DTXSID3046798 Css 3compartmentss Human 95% 11.68 mg/L 10.55 mg/L 1.10710900473934 -DTXSID3046821 Css 3compartmentss Human 95% 0.9931 mg/L 0.7202 mg/L 1.3789225215218 -DTXSID3046823 Css 3compartmentss Human 95% 8.813 mg/L 4.229 mg/L 2.08394419484512 -DTXSID3046825 Css 3compartmentss Human 95% 7.299 mg/L 4.813 mg/L 1.51651776438812 -DTXSID3046827 Css 3compartmentss Human 95% 1.77 mg/L 0.9153 mg/L 1.93379219927892 -DTXSID3046829 Css 3compartmentss Human 95% 2.981 mg/L 2.081 mg/L 1.43248438250841 -DTXSID3046871 Css 3compartmentss Human 95% 5.939 mg/L 3.421 mg/L 1.73604209295528 -DTXSID3046875 Css 3compartmentss Human 95% 0.6228 mg/L 0.3862 mg/L 1.6126359399275 -DTXSID3046879 Css 3compartmentss Human 95% 215.6 mg/L 211.5 mg/L 1.0193853427896 -DTXSID3046902 Css 3compartmentss Human 95% 0.8638 mg/L 0.4839 mg/L 1.78507956189295 -DTXSID3046904 Css 3compartmentss Human 95% 0.1537 mg/L 5.645e-06 mg/L 27227.6350752879 -DTXSID3046906 Css 3compartmentss Human 95% 150.7 mg/L 88.43 mg/L 1.7041727920389 -DTXSID3046908 Css 3compartmentss Human 95% 372.2 mg/L 363.8 mg/L 1.02308960967565 -DTXSID3047003 Css 3compartmentss Human 95% 8.172 mg/L 5.125 mg/L 1.59453658536585 -DTXSID3047051 Css 3compartmentss Human 95% 81.68 mg/L 12.12 mg/L 6.73927392739274 -DTXSID3047132 Css 3compartmentss Human 95% 0.977 mg/L 0.6369 mg/L 1.53399277751609 -DTXSID3047180 Css 3compartmentss Human 95% 4.814e-06 mg/L 0 mg/L Inf -DTXSID3047182 Css 3compartmentss Human 95% 3.695 mg/L 3.761e-05 mg/L 98245.1475671364 -DTXSID3047184 Css 3compartmentss Human 95% 2.548 mg/L 2.395 mg/L 1.06388308977035 -DTXSID3047186 Css 3compartmentss Human 95% 0.4911 mg/L 0.2824 mg/L 1.73902266288952 -DTXSID3047261 Css 3compartmentss Human 95% 133.7 mg/L 77.42 mg/L 1.72694394213382 -DTXSID3047263 Css 3compartmentss Human 95% 15.83 mg/L 10.5 mg/L 1.50761904761905 -DTXSID3047265 Css 3compartmentss Human 95% 47.02 mg/L 24.08 mg/L 1.95265780730897 -DTXSID3047267 Css 3compartmentss Human 95% 0.9797 mg/L 0.5797 mg/L 1.69001207521132 -DTXSID3047342 Css 3compartmentss Human 95% 0.2415 mg/L 0.0007419 mg/L 325.515568135867 -DTXSID3047344 Css 3compartmentss Human 95% 4.526 mg/L 2.977 mg/L 1.52032247228754 -DTXSID3047346 Css 3compartmentss Human 95% 0.08259 mg/L 0.05904 mg/L 1.39888211382114 -DTXSID3047348 Css 3compartmentss Human 95% 1.432 mg/L 0.4923 mg/L 2.9087954499289 -DTXSID3047394 Css 3compartmentss Human 95% 0.5036 mg/L 3.371e-06 mg/L 149391.871848116 -DTXSID3047423 Css 3compartmentss Human 95% 2.96 mg/L 1.715 mg/L 1.72594752186589 -DTXSID3047425 Css 3compartmentss Human 95% 0.9838 mg/L 0.3729 mg/L 2.63824081523197 -DTXSID3047427 Css 3compartmentss Human 95% 15.63 mg/L 7.032e-06 mg/L 2222696.24573379 -DTXSID3047429 Css 3compartmentss Human 95% 3.037 mg/L 1.766 mg/L 1.71970554926387 -DTXSID3047471 Css 3compartmentss Human 95% 5.124 mg/L 3.747 mg/L 1.36749399519616 -DTXSID3047473 Css 3compartmentss Human 95% 12.59 mg/L 5.723 mg/L 2.19989515988118 -DTXSID3047477 Css 3compartmentss Human 95% 6.642 mg/L 3.185 mg/L 2.08540031397174 -DTXSID3047504 Css 3compartmentss Human 95% 0.05456 mg/L 0.03778 mg/L 1.44415034409741 -DTXSID3047508 Css 3compartmentss Human 95% 7.507 mg/L 2.658 mg/L 2.82430398796087 -DTXSID3047554 Css 3compartmentss Human 95% 6.278 mg/L 3.469 mg/L 1.8097434419141 -DTXSID3047556 Css 3compartmentss Human 95% 10.45 mg/L 0.1028 mg/L 101.653696498054 -DTXSID3047558 Css 3compartmentss Human 95% 1.323 mg/L 0.2586 mg/L 5.11600928074246 -DTXSID3047631 Css 3compartmentss Human 95% 5.266 mg/L 3.999 mg/L 1.31682920730183 -DTXSID3047633 Css 3compartmentss Human 95% 2.813 mg/L 8e-09 mg/L 351625000 -DTXSID3047681 Css 3compartmentss Human 95% 4.764 mg/L 2.244 mg/L 2.12299465240642 -DTXSID3047683 Css 3compartmentss Human 95% 2.267 mg/L 1.646 mg/L 1.37727825030377 -DTXSID3047687 Css 3compartmentss Human 95% 6.477 mg/L 3.964 mg/L 1.63395560040363 -DTXSID3047716 Css 3compartmentss Human 95% 5.437 mg/L 3.274 mg/L 1.66065974343311 -DTXSID3047843 Css 3compartmentss Human 95% 23.11 mg/L 0.4441 mg/L 52.0378293177212 -DTXSID3047845 Css 3compartmentss Human 95% 0.762 mg/L 0.5799 mg/L 1.31401965856182 -DTXSID3047847 Css 3compartmentss Human 95% 0.556 mg/L 0.3931 mg/L 1.41439837191554 -DTXSID3047849 Css 3compartmentss Human 95% 1.06 mg/L 0.6711 mg/L 1.57949634927731 -DTXSID3047891 Css 3compartmentss Human 95% 0.8273 mg/L 0.5902 mg/L 1.40172822771942 -DTXSID3047893 Css 3compartmentss Human 95% 33.11 mg/L 0.03961 mg/L 835.90002524615 -DTXSID3047895 Css 3compartmentss Human 95% 8.196 mg/L 2.656 mg/L 3.08584337349398 -DTXSID3047897 Css 3compartmentss Human 95% 5.769 mg/L 3.628 mg/L 1.59013230429989 -DTXSID3047920 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID3047924 Css 3compartmentss Human 95% 9.973 mg/L 6.206 mg/L 1.60699323235578 -DTXSID3047926 Css 3compartmentss Human 95% 0.643 mg/L 0.07957 mg/L 8.08093502576348 -DTXSID3047970 Css 3compartmentss Human 95% 0.2448 mg/L 0.07919 mg/L 3.09129940649072 -DTXSID3047972 Css 3compartmentss Human 95% 5.398 mg/L 3.501 mg/L 1.5418451870894 -DTXSID3047974 Css 3compartmentss Human 95% 88.42 mg/L 57.35 mg/L 1.54176111595466 -DTXSID3048310 Css 3compartmentss Human 95% 6.063 mg/L 4.033 mg/L 1.50334738408133 -DTXSID3048449 Css 3compartmentss Human 95% 0.3297 mg/L 0.2111 mg/L 1.56181904310753 -DTXSID3048520 Css 3compartmentss Human 95% 0.739 mg/L 0.518 mg/L 1.42664092664093 -DTXSID3048522 Css 3compartmentss Human 95% 1.164 mg/L 5.136e-05 mg/L 22663.5514018692 -DTXSID3048574 Css 3compartmentss Human 95% 7.49 mg/L 5.847 mg/L 1.28099880280486 -DTXSID3048576 Css 3compartmentss Human 95% 10.76 mg/L 6.11 mg/L 1.76104746317512 -DTXSID3048578 Css 3compartmentss Human 95% 4.548 mg/L 2.656 mg/L 1.71234939759036 -DTXSID3048601 Css 3compartmentss Human 95% 5.968 mg/L 2.982 mg/L 2.00134138162307 -DTXSID3048603 Css 3compartmentss Human 95% 1.47 mg/L 0.8071 mg/L 1.8213356461405 -DTXSID3048605 Css 3compartmentss Human 95% 0.0655 mg/L 0.04228 mg/L 1.54919583727531 -DTXSID3048607 Css 3compartmentss Human 95% 10.07 mg/L 5.053 mg/L 1.99287551949337 -DTXSID3048609 Css 3compartmentss Human 95% 0.3947 mg/L 0.2974 mg/L 1.32716879623403 -DTXSID3048653 Css 3compartmentss Human 95% 2.593 mg/L 1.529e-05 mg/L 169587.965990844 -DTXSID3048655 Css 3compartmentss Human 95% 0.7527 mg/L 0.8448 mg/L 0.890980113636364 -DTXSID3048657 Css 3compartmentss Human 95% 22.53 mg/L 0.007289 mg/L 3090.95897928385 -DTXSID3048659 Css 3compartmentss Human 95% 0.9804 mg/L 0.6882 mg/L 1.42458587619878 -DTXSID3048730 Css 3compartmentss Human 95% 15.18 mg/L 9.374 mg/L 1.61937273309153 -DTXSID3048732 Css 3compartmentss Human 95% 12.65 mg/L 7.21 mg/L 1.75450762829404 -DTXSID3048734 Css 3compartmentss Human 95% 1.112 mg/L 0.01168 mg/L 95.2054794520548 -DTXSID3048736 Css 3compartmentss Human 95% 4.227 mg/L 1.863 mg/L 2.26892109500805 -DTXSID3048738 Css 3compartmentss Human 95% 4.078 mg/L 2.65 mg/L 1.5388679245283 -DTXSID3048780 Css 3compartmentss Human 95% 8.264 mg/L 2.72 mg/L 3.03823529411765 -DTXSID3048782 Css 3compartmentss Human 95% 310.9 mg/L 180.7 mg/L 1.72053126729386 -DTXSID3048788 Css 3compartmentss Human 95% 1.11 mg/L 0.6136 mg/L 1.80899608865711 -DTXSID3048811 Css 3compartmentss Human 95% 4.694 mg/L 0.1039 mg/L 45.1780558229066 -DTXSID3048813 Css 3compartmentss Human 95% 0.06917 mg/L 0.03988 mg/L 1.73445336008024 -DTXSID3048815 Css 3compartmentss Human 95% 2.822 mg/L 1.502 mg/L 1.87882822902796 -DTXSID3048817 Css 3compartmentss Human 95% 6.026 mg/L 3.732 mg/L 1.61468381564845 -DTXSID3048819 Css 3compartmentss Human 95% 9.626 mg/L 5.92 mg/L 1.62601351351351 -DTXSID3048861 Css 3compartmentss Human 95% 9.105 mg/L 5.498 mg/L 1.65605674790833 -DTXSID3048863 Css 3compartmentss Human 95% 5.918 mg/L 3.478 mg/L 1.70155261644623 -DTXSID3048865 Css 3compartmentss Human 95% 0.372 mg/L 0.2673 mg/L 1.39169472502806 -DTXSID3048867 Css 3compartmentss Human 95% 1.519 mg/L 1.241 mg/L 1.22401289282836 -DTXSID3048869 Css 3compartmentss Human 95% 0.3026 mg/L 0.2346 mg/L 1.28985507246377 -DTXSID3048940 Css 3compartmentss Human 95% 8.696 mg/L 5.277 mg/L 1.64790600720106 -DTXSID3048942 Css 3compartmentss Human 95% 1.714 mg/L 0.3258 mg/L 5.26089625537139 -DTXSID3048944 Css 3compartmentss Human 95% 37.61 mg/L 17.6 mg/L 2.13693181818182 -DTXSID3048946 Css 3compartmentss Human 95% 9262 mg/L 9099 mg/L 1.01791405648972 -DTXSID3048948 Css 3compartmentss Human 95% 10.94 mg/L 4.604 mg/L 2.37619461337967 -DTXSID3048990 Css 3compartmentss Human 95% 6.515 mg/L 4.146 mg/L 1.57139411480945 -DTXSID3048992 Css 3compartmentss Human 95% 2.054 mg/L 1.076 mg/L 1.9089219330855 -DTXSID3048996 Css 3compartmentss Human 95% 2.587 mg/L 3.614e-05 mg/L 71582.7338129496 -DTXSID3048998 Css 3compartmentss Human 95% 21.48 mg/L 9.787 mg/L 2.1947481352815 -DTXSID3049041 Css 3compartmentss Human 95% 0.2532 mg/L 0.1593 mg/L 1.5894538606403 -DTXSID3049043 Css 3compartmentss Human 95% 4.968 mg/L 0.002886 mg/L 1721.41372141372 -DTXSID3049045 Css 3compartmentss Human 95% 0.1877 mg/L 0.1226 mg/L 1.53099510603589 -DTXSID3049047 Css 3compartmentss Human 95% 1.095 mg/L 0.5877 mg/L 1.8631955079122 -DTXSID3049049 Css 3compartmentss Human 95% 17.76 mg/L 5.029 mg/L 3.53151720023862 -DTXSID3049201 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID3049209 Css 3compartmentss Human 95% 10.03 mg/L 2.521 mg/L 3.97857992859976 -DTXSID3049253 Css 3compartmentss Human 95% 2.326 mg/L 0.2671 mg/L 8.7083489329839 -DTXSID3049330 Css 3compartmentss Human 95% 6.877 mg/L 4.178 mg/L 1.64600287218765 -DTXSID3049334 Css 3compartmentss Human 95% 5.866 mg/L 3.796 mg/L 1.54531085353003 -DTXSID3049336 Css 3compartmentss Human 95% 5.035 mg/L 3.282 mg/L 1.53412553321146 -DTXSID3049338 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID3049382 Css 3compartmentss Human 95% 11.83 mg/L 0.3104 mg/L 38.1121134020619 -DTXSID3049413 Css 3compartmentss Human 95% 1.772 mg/L 1.069 mg/L 1.65762394761459 -DTXSID3049415 Css 3compartmentss Human 95% 1.236 mg/L 0.8793 mg/L 1.40566359604231 -DTXSID3049417 Css 3compartmentss Human 95% 6.459 mg/L 3.969 mg/L 1.62736205593348 -DTXSID3049419 Css 3compartmentss Human 95% 0.304 mg/L 0.2219 mg/L 1.36998648039658 -DTXSID3051707 Css 3compartmentss Human 95% 0.1829 mg/L 0.1172 mg/L 1.56058020477816 -DTXSID3051834 Css 3compartmentss Human 95% 3.386 mg/L 0.1628 mg/L 20.7985257985258 -DTXSID3051836 Css 3compartmentss Human 95% 6.022 mg/L 3.904 mg/L 1.54252049180328 -DTXSID3052278 Css 3compartmentss Human 95% 2.712 mg/L 1.622 mg/L 1.67200986436498 -DTXSID3052301 Css 3compartmentss Human 95% 0.5014 mg/L 0.344 mg/L 1.45755813953488 -DTXSID3052511 Css 3compartmentss Human 95% 55.46 mg/L 0.785 mg/L 70.6496815286624 -DTXSID3052567 Css 3compartmentss Human 95% 7.726 mg/L 5.272 mg/L 1.4654779969651 -DTXSID3057640 Css 3compartmentss Human 95% 0.2048 mg/L 0.1093 mg/L 1.87374199451052 -DTXSID3057642 Css 3compartmentss Human 95% 1.038 mg/L 0.5834 mg/L 1.77922523140213 -DTXSID3057644 Css 3compartmentss Human 95% 11.73 mg/L 4.117 mg/L 2.84916201117318 -DTXSID3057646 Css 3compartmentss Human 95% 4.609 mg/L 2.853 mg/L 1.61549246407291 -DTXSID3057648 Css 3compartmentss Human 95% 2.411 mg/L 0.6182 mg/L 3.90003235198965 -DTXSID3057690 Css 3compartmentss Human 95% 6.202 mg/L 2.959 mg/L 2.09597837107131 -DTXSID3057692 Css 3compartmentss Human 95% 1.476 mg/L 1.119 mg/L 1.31903485254692 -DTXSID3057694 Css 3compartmentss Human 95% 0.3303 mg/L 0.1834 mg/L 1.8009814612868 -DTXSID3057696 Css 3compartmentss Human 95% 1.14 mg/L 0.7412 mg/L 1.53804641122504 -DTXSID3057698 Css 3compartmentss Human 95% 5.399 mg/L 3.66 mg/L 1.47513661202186 -DTXSID3057723 Css 3compartmentss Human 95% 4.022 mg/L 2.118 mg/L 1.89896128423041 -DTXSID3057725 Css 3compartmentss Human 95% 7.722 mg/L 4.847 mg/L 1.59315040231071 -DTXSID3057727 Css 3compartmentss Human 95% 7.961 mg/L 5.066 mg/L 1.57145677062771 -DTXSID3057729 Css 3compartmentss Human 95% 2.912 mg/L 1.886 mg/L 1.5440084835631 -DTXSID3057771 Css 3compartmentss Human 95% 47.01 mg/L 25.27 mg/L 1.86030866640285 -DTXSID3057773 Css 3compartmentss Human 95% 5.572 mg/L 3.278 mg/L 1.69981696156193 -DTXSID3057775 Css 3compartmentss Human 95% 0.0375 mg/L 0.02156 mg/L 1.73933209647495 -DTXSID3057777 Css 3compartmentss Human 95% 5.928 mg/L 6.522 mg/L 0.908923643054278 -DTXSID3057779 Css 3compartmentss Human 95% 0.07369 mg/L 0.06186 mg/L 1.19123827998707 -DTXSID3057800 Css 3compartmentss Human 95% 1.268 mg/L 0.8285 mg/L 1.53047676523838 -DTXSID3057802 Css 3compartmentss Human 95% 1.565 mg/L 0.939 mg/L 1.66666666666667 -DTXSID3057804 Css 3compartmentss Human 95% 5.14 mg/L 3.326 mg/L 1.54539987973542 -DTXSID3057806 Css 3compartmentss Human 95% 1.884 mg/L 1.013 mg/L 1.85982230997039 -DTXSID3057808 Css 3compartmentss Human 95% 5.46 mg/L 3.509 mg/L 1.5559988600741 -DTXSID3057850 Css 3compartmentss Human 95% 7.476 mg/L 5.03 mg/L 1.48628230616302 -DTXSID3057852 Css 3compartmentss Human 95% 0.2364 mg/L 6e-09 mg/L 39400000 -DTXSID3057854 Css 3compartmentss Human 95% 24.11 mg/L 0.4948 mg/L 48.7267582861762 -DTXSID3057856 Css 3compartmentss Human 95% 0.002001 mg/L 0.001396 mg/L 1.43338108882521 -DTXSID3057858 Css 3compartmentss Human 95% 1.148 mg/L 0.7637 mg/L 1.5032080659945 -DTXSID30865801 Css 3compartmentss Human 95% 0.5026 mg/L 0.2595 mg/L 1.93680154142582 -DTXSID30866414 Css 3compartmentss Human 95% 0.7308 mg/L 0.2253 mg/L 3.24367509986684 -DTXSID401009875 Css 3compartmentss Human 95% 0.5137 mg/L 0.2635 mg/L 1.94952561669829 -DTXSID401017163 Css 3compartmentss Human 95% 2.402 mg/L 0.4802 mg/L 5.00208246563932 -DTXSID40143768 Css 3compartmentss Human 95% 359 mg/L 206.8 mg/L 1.73597678916828 -DTXSID4020032 Css 3compartmentss Human 95% 5.538 mg/L 3.307 mg/L 1.67462957363169 -DTXSID4020038 Css 3compartmentss Human 95% 35.23 mg/L 19.34 mg/L 1.82161323681489 -DTXSID4020086 Css 3compartmentss Human 95% 0.4203 mg/L 0.3442 mg/L 1.22109238814643 -DTXSID4020088 Css 3compartmentss Human 95% 8.982 mg/L 6.061 mg/L 1.48193367431117 -DTXSID4020113 Css 3compartmentss Human 95% 3.625 mg/L 2.506 mg/L 1.44652833200319 -DTXSID4020115 Css 3compartmentss Human 95% 0.8282 mg/L 0.4479 mg/L 1.84907345389596 -DTXSID4020117 Css 3compartmentss Human 95% 5.533 mg/L 3.307 mg/L 1.67311762927124 -DTXSID4020119 Css 3compartmentss Human 95% 6.467 mg/L 4.062 mg/L 1.59207287050714 -DTXSID4020240 Css 3compartmentss Human 95% 3.028 mg/L 2.137 mg/L 1.41693963500234 -DTXSID4020242 Css 3compartmentss Human 95% 127.5 mg/L 207.4 mg/L 0.614754098360656 -DTXSID4020244 Css 3compartmentss Human 95% 5.531 mg/L 2.503 mg/L 2.20974830203755 -DTXSID4020246 Css 3compartmentss Human 95% 15.85 mg/L 9.494 mg/L 1.66947545818412 -DTXSID4020248 Css 3compartmentss Human 95% 24.25 mg/L 15.48 mg/L 1.56653746770026 -DTXSID4020290 Css 3compartmentss Human 95% 145.8 mg/L 78.13 mg/L 1.86612056828363 -DTXSID4020294 Css 3compartmentss Human 95% 1.838 mg/L 1.133 mg/L 1.62224183583407 -DTXSID4020296 Css 3compartmentss Human 95% 0.7639 mg/L 0.5475 mg/L 1.39525114155251 -DTXSID4020321 Css 3compartmentss Human 95% 1.307 mg/L 0.6896 mg/L 1.89530162412993 -DTXSID4020325 Css 3compartmentss Human 95% 6.515 mg/L 4.146 mg/L 1.57139411480945 -DTXSID4020327 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID4020329 Css 3compartmentss Human 95% 0.6153 mg/L 0.4053 mg/L 1.51813471502591 -DTXSID4020371 Css 3compartmentss Human 95% 5.805 mg/L 4.623 mg/L 1.25567813108371 -DTXSID4020373 Css 3compartmentss Human 95% 11190 mg/L 9736 mg/L 1.14934264585045 -DTXSID4020375 Css 3compartmentss Human 95% 21.4 mg/L 0.01047 mg/L 2043.93505253104 -DTXSID4020379 Css 3compartmentss Human 95% 6.25 mg/L 4.119 mg/L 1.51735858218014 -DTXSID4020400 Css 3compartmentss Human 95% 2.354 mg/L 1.66 mg/L 1.41807228915663 -DTXSID4020402 Css 3compartmentss Human 95% 5.408 mg/L 3.409 mg/L 1.58638897037254 -DTXSID4020406 Css 3compartmentss Human 95% 114.7 mg/L 53.91 mg/L 2.12762010758672 -DTXSID4020450 Css 3compartmentss Human 95% 112 mg/L 8.82 mg/L 12.6984126984127 -DTXSID4020458 Css 3compartmentss Human 95% 160.7 mg/L 5.61 mg/L 28.6452762923351 -DTXSID4020533 Css 3compartmentss Human 95% 0.9715 mg/L 0.6864 mg/L 1.41535547785548 -DTXSID4020535 Css 3compartmentss Human 95% 3.266 mg/L 0.5338 mg/L 6.11839640314725 -DTXSID4020537 Css 3compartmentss Human 95% 6.011 mg/L 6.39 mg/L 0.940688575899844 -DTXSID4020581 Css 3compartmentss Human 95% 2.829 mg/L 1.662 mg/L 1.70216606498195 -DTXSID4020587 Css 3compartmentss Human 95% 5.695 mg/L 4.397 mg/L 1.29520127359563 -DTXSID4020589 Css 3compartmentss Human 95% 34.99 mg/L 0.007839 mg/L 4463.5795382064 -DTXSID4020612 Css 3compartmentss Human 95% 1.895 mg/L 1.171 mg/L 1.61827497865073 -DTXSID4020614 Css 3compartmentss Human 95% 1.361 mg/L 0.4591 mg/L 2.96449575255936 -DTXSID4020618 Css 3compartmentss Human 95% 17 mg/L 17.04 mg/L 0.997652582159624 -DTXSID4020664 Css 3compartmentss Human 95% 5.427 mg/L 3.327 mg/L 1.6311992786294 -DTXSID4020666 Css 3compartmentss Human 95% 6.501 mg/L 4.302 mg/L 1.51115760111576 -DTXSID4020668 Css 3compartmentss Human 95% 3.132 mg/L 2.217 mg/L 1.4127198917456 -DTXSID4020745 Css 3compartmentss Human 95% 2.013 mg/L 1.248 mg/L 1.61298076923077 -DTXSID4020749 Css 3compartmentss Human 95% 0.2886 mg/L 0.1375 mg/L 2.09890909090909 -DTXSID4020791 Css 3compartmentss Human 95% 0.07897 mg/L 0.04412 mg/L 1.78989120580236 -DTXSID4020820 Css 3compartmentss Human 95% 5.403 mg/L 3.381 mg/L 1.5980479148181 -DTXSID4020822 Css 3compartmentss Human 95% 3.504 mg/L 2.323 mg/L 1.50839431769264 -DTXSID4020826 Css 3compartmentss Human 95% 0.9936 mg/L 0.6452 mg/L 1.53998760074396 -DTXSID4020828 Css 3compartmentss Human 95% 0.2686 mg/L 0.1744 mg/L 1.5401376146789 -DTXSID4020870 Css 3compartmentss Human 95% 22.28 mg/L 0.1265 mg/L 176.126482213439 -DTXSID4020876 Css 3compartmentss Human 95% 1.423 mg/L 0.9338 mg/L 1.52388091668452 -DTXSID4020901 Css 3compartmentss Human 95% 7.256 mg/L 4.643 mg/L 1.56278268360974 -DTXSID4020957 Css 3compartmentss Human 95% 0.1354 mg/L 0.08702 mg/L 1.55596414617329 -DTXSID4020959 Css 3compartmentss Human 95% 0.3799 mg/L 0.2927 mg/L 1.29791595490263 -DTXSID4021002 Css 3compartmentss Human 95% 0.06465 mg/L 0.03937 mg/L 1.64211328422657 -DTXSID4021006 Css 3compartmentss Human 95% 4.876 mg/L 2.13 mg/L 2.28920187793427 -DTXSID4021056 Css 3compartmentss Human 95% 4.513 mg/L 2.944 mg/L 1.53294836956522 -DTXSID4021131 Css 3compartmentss Human 95% 6.304 mg/L 1.142 mg/L 5.52014010507881 -DTXSID4021133 Css 3compartmentss Human 95% 101.2 mg/L 35.7 mg/L 2.83473389355742 -DTXSID4021135 Css 3compartmentss Human 95% 1623 mg/L 941.8 mg/L 1.72329581652155 -DTXSID4021137 Css 3compartmentss Human 95% 5.471 mg/L 3.507 mg/L 1.56002281151982 -DTXSID4021139 Css 3compartmentss Human 95% 2.35 mg/L 1.44 mg/L 1.63194444444444 -DTXSID4021181 Css 3compartmentss Human 95% 10.76 mg/L 4.274 mg/L 2.51754796443613 -DTXSID4021185 Css 3compartmentss Human 95% 7.274 mg/L 4.912 mg/L 1.48086319218241 -DTXSID4021189 Css 3compartmentss Human 95% 0.1674 mg/L 0.1033 mg/L 1.62052274927396 -DTXSID4021212 Css 3compartmentss Human 95% 9.562 mg/L 5.763 mg/L 1.65920527503037 -DTXSID4021214 Css 3compartmentss Human 95% 91.89 mg/L 51.07 mg/L 1.79929508517721 -DTXSID4021216 Css 3compartmentss Human 95% 0.7764 mg/L 0.5525 mg/L 1.40524886877828 -DTXSID4021218 Css 3compartmentss Human 95% 5.445 mg/L 2.94 mg/L 1.85204081632653 -DTXSID4021260 Css 3compartmentss Human 95% 2.359 mg/L 0.001922 mg/L 1227.36732570239 -DTXSID4021264 Css 3compartmentss Human 95% 11.07 mg/L 10.46 mg/L 1.05831739961759 -DTXSID4021268 Css 3compartmentss Human 95% 1.533 mg/L 1.113 mg/L 1.37735849056604 -DTXSID4021341 Css 3compartmentss Human 95% 0.8198 mg/L 5.269e-06 mg/L 155589.295881571 -DTXSID4021343 Css 3compartmentss Human 95% 11.09 mg/L 6.759 mg/L 1.64077526261281 -DTXSID4021347 Css 3compartmentss Human 95% 5.245 mg/L 3.379 mg/L 1.55223438887245 -DTXSID4021391 Css 3compartmentss Human 95% 6.763 mg/L 0.02622 mg/L 257.932875667429 -DTXSID4021393 Css 3compartmentss Human 95% 5.515 mg/L 3.307 mg/L 1.66767462957363 -DTXSID4021397 Css 3compartmentss Human 95% 100 mg/L 51.99 mg/L 1.92344681669552 -DTXSID4021424 Css 3compartmentss Human 95% 5.473 mg/L 3.858 mg/L 1.41861067910835 -DTXSID4021426 Css 3compartmentss Human 95% 5.652 mg/L 3.603 mg/L 1.56869275603664 -DTXSID40214326 Css 3compartmentss Human 95% 385.6 mg/L 231.8 mg/L 1.66350301984469 -DTXSID4021478 Css 3compartmentss Human 95% 15.9 mg/L 6.308 mg/L 2.52060875079264 -DTXSID4021559 Css 3compartmentss Human 95% 37.21 mg/L 13.43 mg/L 2.77066269545793 -DTXSID4021632 Css 3compartmentss Human 95% 6.279 mg/L 3.719 mg/L 1.68835708523797 -DTXSID4021636 Css 3compartmentss Human 95% 7.911 mg/L 4.907 mg/L 1.61218667210108 -DTXSID4021638 Css 3compartmentss Human 95% 0.4801 mg/L 0.3063 mg/L 1.56741756447927 -DTXSID4021680 Css 3compartmentss Human 95% 7.617 mg/L 4.708 mg/L 1.6178844519966 -DTXSID4021684 Css 3compartmentss Human 95% 53.74 mg/L 24.71 mg/L 2.17482800485633 -DTXSID4021717 Css 3compartmentss Human 95% 57.76 mg/L 35.82 mg/L 1.61250697934115 -DTXSID4021761 Css 3compartmentss Human 95% 5.511 mg/L 3.658 mg/L 1.50656096227447 -DTXSID4021842 Css 3compartmentss Human 95% 5.855 mg/L 3.614 mg/L 1.62008854454898 -DTXSID4021848 Css 3compartmentss Human 95% 2.413 mg/L 1.48 mg/L 1.63040540540541 -DTXSID4021892 Css 3compartmentss Human 95% 1.174 mg/L 1.374 mg/L 0.854439592430859 -DTXSID4021894 Css 3compartmentss Human 95% 6.081 mg/L 4.327 mg/L 1.40536168245898 -DTXSID4021921 Css 3compartmentss Human 95% 5.068 mg/L 3.553 mg/L 1.42640022516184 -DTXSID4021971 Css 3compartmentss Human 95% 1.861 mg/L 1.357 mg/L 1.37140751658069 -DTXSID4021973 Css 3compartmentss Human 95% 0.4622 mg/L 0.3253 mg/L 1.42084229941592 -DTXSID4021975 Css 3compartmentss Human 95% 16.86 mg/L 4.526 mg/L 3.72514361467079 -DTXSID4021977 Css 3compartmentss Human 95% 1.582 mg/L 1.202 mg/L 1.31613976705491 -DTXSID4021979 Css 3compartmentss Human 95% 5.326 mg/L 3.519 mg/L 1.51349815288434 -DTXSID4022020 Css 3compartmentss Human 95% 56.21 mg/L 35.41 mg/L 1.58740468794126 -DTXSID4022107 Css 3compartmentss Human 95% 2.112 mg/L 1.448 mg/L 1.4585635359116 -DTXSID4022109 Css 3compartmentss Human 95% 16.54 mg/L 21.9 mg/L 0.755251141552511 -DTXSID4022153 Css 3compartmentss Human 95% 0.0005608 mg/L 0 mg/L Inf -DTXSID4022284 Css 3compartmentss Human 95% 5.13 mg/L 3.512 mg/L 1.46070615034169 -DTXSID4022288 Css 3compartmentss Human 95% 2.268 mg/L 0.8445 mg/L 2.68561278863233 -DTXSID4022311 Css 3compartmentss Human 95% 4.003 mg/L 2.078 mg/L 1.92637151106834 -DTXSID4022315 Css 3compartmentss Human 95% 8.724 mg/L 4.819 mg/L 1.81033409421042 -DTXSID4022361 Css 3compartmentss Human 95% 1.296 mg/L 1.233 mg/L 1.05109489051095 -DTXSID4022367 Css 3compartmentss Human 95% 79.33 mg/L 74.1 mg/L 1.07058029689609 -DTXSID4022369 Css 3compartmentss Human 95% 0.1239 mg/L 1e-09 mg/L 123900000 -DTXSID4022442 Css 3compartmentss Human 95% 8.785 mg/L 2.449 mg/L 3.58717844017967 -DTXSID4022446 Css 3compartmentss Human 95% 1.279 mg/L 0.5346 mg/L 2.3924429479985 -DTXSID4022448 Css 3compartmentss Human 95% 1.006 mg/L 0.7779 mg/L 1.2932253503021 -DTXSID4022521 Css 3compartmentss Human 95% 0.03227 mg/L 0 mg/L Inf -DTXSID4022523 Css 3compartmentss Human 95% 3.474 mg/L 0.2663 mg/L 13.0454374765302 -DTXSID4022525 Css 3compartmentss Human 95% 7.639 mg/L 1.887 mg/L 4.04822469528352 -DTXSID4022527 Css 3compartmentss Human 95% 1.936 mg/L 1.065 mg/L 1.81784037558685 -DTXSID4022529 Css 3compartmentss Human 95% 0.677 mg/L 0.3027 mg/L 2.23653782623059 -DTXSID4022571 Css 3compartmentss Human 95% 1.435 mg/L 1.267 mg/L 1.13259668508287 -DTXSID4022573 Css 3compartmentss Human 95% 0.8761 mg/L 0.6064 mg/L 1.44475593667546 -DTXSID4022577 Css 3compartmentss Human 95% 5.046 mg/L 3.254 mg/L 1.55070682237246 -DTXSID4022579 Css 3compartmentss Human 95% 0.9461 mg/L 0.8762 mg/L 1.07977630677927 -DTXSID4022600 Css 3compartmentss Human 95% 4.485 mg/L 2.994 mg/L 1.49799599198397 -DTXSID4022602 Css 3compartmentss Human 95% 1.463 mg/L 0.9653 mg/L 1.51559100797679 -DTXSID4022652 Css 3compartmentss Human 95% 612.4 mg/L 143.8 mg/L 4.2586926286509 -DTXSID4022658 Css 3compartmentss Human 95% 10.75 mg/L 5.538 mg/L 1.9411339833875 -DTXSID40227299 Css 3compartmentss Human 95% 2.02 mg/L 0.7299 mg/L 2.76750239758871 -DTXSID4022731 Css 3compartmentss Human 95% 1.244 mg/L 0.8759 mg/L 1.42025345359059 -DTXSID4022735 Css 3compartmentss Human 95% 8.136 mg/L 5.135 mg/L 1.58442064264849 -DTXSID4022783 Css 3compartmentss Human 95% 7.226 mg/L 3.964 mg/L 1.82290615539859 -DTXSID4022785 Css 3compartmentss Human 95% 1.501 mg/L 0.7265 mg/L 2.06607019958706 -DTXSID4022787 Css 3compartmentss Human 95% 515.9 mg/L 336.1 mg/L 1.53495983338292 -DTXSID4022789 Css 3compartmentss Human 95% 4.562 mg/L 2.229 mg/L 2.0466576940332 -DTXSID4022810 Css 3compartmentss Human 95% 5.206 mg/L 0.031 mg/L 167.935483870968 -DTXSID4022812 Css 3compartmentss Human 95% 0.3729 mg/L 0.2293 mg/L 1.62625381596162 -DTXSID4022814 Css 3compartmentss Human 95% 2774 mg/L 2208 mg/L 1.25634057971015 -DTXSID4022816 Css 3compartmentss Human 95% 124.2 mg/L 66.69 mg/L 1.86234817813765 -DTXSID4022862 Css 3compartmentss Human 95% 24.31 mg/L 5.295 mg/L 4.59112370160529 -DTXSID4022866 Css 3compartmentss Human 95% 6.19 mg/L 0.01636 mg/L 378.361858190709 -DTXSID4022868 Css 3compartmentss Human 95% 10.09 mg/L 5.556 mg/L 1.81605471562275 -DTXSID4022941 Css 3compartmentss Human 95% 27.43 mg/L 1.68 mg/L 16.327380952381 -DTXSID4022947 Css 3compartmentss Human 95% 51.85 mg/L 31 mg/L 1.67258064516129 -DTXSID4022949 Css 3compartmentss Human 95% 1.77 mg/L 0.6637 mg/L 2.66686756064487 -DTXSID4022991 Css 3compartmentss Human 95% 22.32 mg/L 34.99 mg/L 0.637896541869105 -DTXSID4022993 Css 3compartmentss Human 95% 0.0356 mg/L 0.03018 mg/L 1.17958913187541 -DTXSID4022999 Css 3compartmentss Human 95% 3.674 mg/L 3.534e-06 mg/L 1039615.16694963 -DTXSID4023042 Css 3compartmentss Human 95% 169.4 mg/L 322.4 mg/L 0.525434243176179 -DTXSID4023044 Css 3compartmentss Human 95% 0.6371 mg/L 0.3187 mg/L 1.99905867587072 -DTXSID4023094 Css 3compartmentss Human 95% 4.008 mg/L 2.238 mg/L 1.79088471849866 -DTXSID4023096 Css 3compartmentss Human 95% 6.528 mg/L 3.479 mg/L 1.87640126473124 -DTXSID4023123 Css 3compartmentss Human 95% 0.3484 mg/L 0.111 mg/L 3.13873873873874 -DTXSID4023125 Css 3compartmentss Human 95% 1.403 mg/L 0.98 mg/L 1.43163265306122 -DTXSID4023171 Css 3compartmentss Human 95% 5.688 mg/L 3.483 mg/L 1.63307493540052 -DTXSID4023175 Css 3compartmentss Human 95% 4.09 mg/L 2.91 mg/L 1.40549828178694 -DTXSID4023179 Css 3compartmentss Human 95% 11.55 mg/L 2.268 mg/L 5.09259259259259 -DTXSID4023200 Css 3compartmentss Human 95% 2.008 mg/L 0.7701 mg/L 2.60745357745747 -DTXSID4023202 Css 3compartmentss Human 95% 3.519 mg/L 2.751 mg/L 1.27917121046892 -DTXSID4023252 Css 3compartmentss Human 95% 4.326 mg/L 3.463 mg/L 1.24920589084609 -DTXSID4023254 Css 3compartmentss Human 95% 0.1638 mg/L 0.1129 mg/L 1.45084145261293 -DTXSID4023258 Css 3compartmentss Human 95% 5.055 mg/L 3.506 mg/L 1.44181403308614 -DTXSID4023333 Css 3compartmentss Human 95% 31.4 mg/L 7.246 mg/L 4.33342533811758 -DTXSID4023381 Css 3compartmentss Human 95% 2.078 mg/L 1.268 mg/L 1.63880126182965 -DTXSID4023385 Css 3compartmentss Human 95% 4.633 mg/L 2.352 mg/L 1.96981292517007 -DTXSID4023387 Css 3compartmentss Human 95% 1.053 mg/L 0.585 mg/L 1.8 -DTXSID4023412 Css 3compartmentss Human 95% 8.253 mg/L 5.087 mg/L 1.62237074896796 -DTXSID4023414 Css 3compartmentss Human 95% 7.128 mg/L 4.417 mg/L 1.61376499886801 -DTXSID4023416 Css 3compartmentss Human 95% 8.733 mg/L 4.429 mg/L 1.97177692481373 -DTXSID4023460 Css 3compartmentss Human 95% 0.07687 mg/L 0.05078 mg/L 1.51378495470658 -DTXSID4023462 Css 3compartmentss Human 95% 1.623 mg/L 0.5646 mg/L 2.87460148777896 -DTXSID4023541 Css 3compartmentss Human 95% 3.082 mg/L 2.192 mg/L 1.40602189781022 -DTXSID4023545 Css 3compartmentss Human 95% 40.86 mg/L 22.13 mg/L 1.8463624039765 -DTXSID4023549 Css 3compartmentss Human 95% 3.436 mg/L 1.447 mg/L 2.37456807187284 -DTXSID4023591 Css 3compartmentss Human 95% 1.438 mg/L 0.9337 mg/L 1.54010924279747 -DTXSID4023593 Css 3compartmentss Human 95% 6.331 mg/L 1.414 mg/L 4.47736916548798 -DTXSID4023595 Css 3compartmentss Human 95% 0.04885 mg/L 0.04797 mg/L 1.0183447988326 -DTXSID4023620 Css 3compartmentss Human 95% 0.4397 mg/L 0.2611 mg/L 1.6840291076216 -DTXSID4023622 Css 3compartmentss Human 95% 2.013 mg/L 2.191 mg/L 0.918758557736194 -DTXSID4023624 Css 3compartmentss Human 95% 536.5 mg/L 309.5 mg/L 1.73344103392569 -DTXSID4023626 Css 3compartmentss Human 95% 1.807 mg/L 1.113 mg/L 1.62353998203055 -DTXSID4023628 Css 3compartmentss Human 95% 1.08 mg/L 0.7572 mg/L 1.42630744849445 -DTXSID4023670 Css 3compartmentss Human 95% 377.7 mg/L 212.3 mg/L 1.77908619877532 -DTXSID4023672 Css 3compartmentss Human 95% 6.368 mg/L 4.827 mg/L 1.31924590843174 -DTXSID4023674 Css 3compartmentss Human 95% 1.412 mg/L 0.8488 mg/L 1.66352497643732 -DTXSID4023676 Css 3compartmentss Human 95% 4.099 mg/L 2.607 mg/L 1.572305331799 -DTXSID4023678 Css 3compartmentss Human 95% 1.159 mg/L 0.3841 mg/L 3.01744337412132 -DTXSID4023701 Css 3compartmentss Human 95% 67.45 mg/L 0.2577 mg/L 261.738455568491 -DTXSID4023753 Css 3compartmentss Human 95% 176.4 mg/L 43.2 mg/L 4.08333333333333 -DTXSID4024018 Css 3compartmentss Human 95% 15.52 mg/L 9.741 mg/L 1.5932655784827 -DTXSID4024062 Css 3compartmentss Human 95% 1.67 mg/L 1.171 mg/L 1.42613151152861 -DTXSID4024064 Css 3compartmentss Human 95% 221.3 mg/L 125.5 mg/L 1.76334661354582 -DTXSID4024066 Css 3compartmentss Human 95% 3.219 mg/L 1.678 mg/L 1.91835518474374 -DTXSID4024143 Css 3compartmentss Human 95% 1.858 mg/L 1.217 mg/L 1.52670501232539 -DTXSID4024145 Css 3compartmentss Human 95% 1.02 mg/L 0.6258 mg/L 1.62991371045062 -DTXSID4024193 Css 3compartmentss Human 95% 59.04 mg/L 30.6 mg/L 1.92941176470588 -DTXSID4024195 Css 3compartmentss Human 95% 305.2 mg/L 218.3 mg/L 1.39807604214384 -DTXSID4024222 Css 3compartmentss Human 95% 5.125 mg/L 2.093 mg/L 2.44863831820354 -DTXSID4024270 Css 3compartmentss Human 95% 15.15 mg/L 3.511 mg/L 4.31500996866989 -DTXSID4024272 Css 3compartmentss Human 95% 2.332 mg/L 1.426 mg/L 1.63534361851332 -DTXSID4024274 Css 3compartmentss Human 95% 0.1415 mg/L 0.09218 mg/L 1.53504013885875 -DTXSID4024276 Css 3compartmentss Human 95% 15.75 mg/L 1.435 mg/L 10.9756097560976 -DTXSID4024303 Css 3compartmentss Human 95% 7.102 mg/L 4.459 mg/L 1.59273379681543 -DTXSID4024359 Css 3compartmentss Human 95% 31.02 mg/L 11.8 mg/L 2.62881355932203 -DTXSID4024436 Css 3compartmentss Human 95% 266.2 mg/L 153.6 mg/L 1.73307291666667 -DTXSID4024484 Css 3compartmentss Human 95% 0.2419 mg/L 0.1403 mg/L 1.72416250890948 -DTXSID4024488 Css 3compartmentss Human 95% 0.2754 mg/L 0.1715 mg/L 1.60583090379009 -DTXSID4024515 Css 3compartmentss Human 95% 8.172 mg/L 5.125 mg/L 1.59453658536585 -DTXSID4024642 Css 3compartmentss Human 95% 7.581 mg/L 4.913 mg/L 1.54304905353145 -DTXSID4024644 Css 3compartmentss Human 95% 9.312 mg/L 5.927 mg/L 1.57111523536359 -DTXSID4024646 Css 3compartmentss Human 95% 2.859 mg/L 1.934 mg/L 1.47828335056877 -DTXSID4024729 Css 3compartmentss Human 95% 0.3151 mg/L 0.2046 mg/L 1.54007820136852 -DTXSID4024771 Css 3compartmentss Human 95% 46.55 mg/L 26.8 mg/L 1.73694029850746 -DTXSID4024800 Css 3compartmentss Human 95% 0.9329 mg/L 0.7033 mg/L 1.3264609697142 -DTXSID4024931 Css 3compartmentss Human 95% 0.1469 mg/L 0.02852 mg/L 5.1507713884993 -DTXSID4024937 Css 3compartmentss Human 95% 12.08 mg/L 1.505 mg/L 8.0265780730897 -DTXSID4024981 Css 3compartmentss Human 95% 87.2 mg/L 47.98 mg/L 1.8174239266361 -DTXSID4024983 Css 3compartmentss Human 95% 3.208 mg/L 2.309 mg/L 1.38934603724556 -DTXSID4025082 Css 3compartmentss Human 95% 0.0025 mg/L 0 mg/L Inf -DTXSID4025113 Css 3compartmentss Human 95% 0.2479 mg/L 0.1872 mg/L 1.32425213675214 -DTXSID4025165 Css 3compartmentss Human 95% 41.11 mg/L 33.12 mg/L 1.24124396135266 -DTXSID4025167 Css 3compartmentss Human 95% 10.88 mg/L 6.134 mg/L 1.77372024779915 -DTXSID4025292 Css 3compartmentss Human 95% 8.094 mg/L 5.527 mg/L 1.4644472589108 -DTXSID4025404 Css 3compartmentss Human 95% 9.171 mg/L 2.023 mg/L 4.53336628769155 -DTXSID4025454 Css 3compartmentss Human 95% 2.609 mg/L 0.8962 mg/L 2.91118054005802 -DTXSID4025581 Css 3compartmentss Human 95% 2.16 mg/L 0.7479 mg/L 2.88808664259928 -DTXSID4025587 Css 3compartmentss Human 95% 0.6234 mg/L 0.464 mg/L 1.34353448275862 -DTXSID4025610 Css 3compartmentss Human 95% 0.08414 mg/L 0.05407 mg/L 1.5561309413723 -DTXSID4025612 Css 3compartmentss Human 95% 1.707 mg/L 1.089 mg/L 1.56749311294766 -DTXSID4025662 Css 3compartmentss Human 95% 1.664 mg/L 1.224 mg/L 1.35947712418301 -DTXSID4025668 Css 3compartmentss Human 95% 0.1575 mg/L 0.1429 mg/L 1.10216934919524 -DTXSID4025741 Css 3compartmentss Human 95% 2.153 mg/L 1.346 mg/L 1.59955423476969 -DTXSID4025743 Css 3compartmentss Human 95% 3.968 mg/L 4.034 mg/L 0.983639067922657 -DTXSID4025745 Css 3compartmentss Human 95% 3.671 mg/L 3.681 mg/L 0.997283346916599 -DTXSID4025749 Css 3compartmentss Human 95% 12.75 mg/L 6.683 mg/L 1.90782582672452 -DTXSID4025791 Css 3compartmentss Human 95% 1.458 mg/L 1.167 mg/L 1.24935732647815 -DTXSID4025824 Css 3compartmentss Human 95% 6.741 mg/L 5.934 mg/L 1.13599595551062 -DTXSID4025903 Css 3compartmentss Human 95% 6.068 mg/L 3.639 mg/L 1.66749106897499 -DTXSID4026000 Css 3compartmentss Human 95% 55.33 mg/L 30.13 mg/L 1.83637570527713 -DTXSID4026054 Css 3compartmentss Human 95% 5.247 mg/L 4.053 mg/L 1.29459659511473 -DTXSID4026137 Css 3compartmentss Human 95% 23.78 mg/L 7.818 mg/L 3.04169864415452 -DTXSID4026139 Css 3compartmentss Human 95% 2.963 mg/L 1.835 mg/L 1.61471389645777 -DTXSID4026181 Css 3compartmentss Human 95% 20.91 mg/L 4.206 mg/L 4.97146932952924 -DTXSID4026212 Css 3compartmentss Human 95% 26.05 mg/L 10.98 mg/L 2.37249544626594 -DTXSID4026214 Css 3compartmentss Human 95% 51.03 mg/L 4.372 mg/L 11.6720036596523 -DTXSID4026262 Css 3compartmentss Human 95% 0.05112 mg/L 0.03257 mg/L 1.5695425237949 -DTXSID4026266 Css 3compartmentss Human 95% 5.488 mg/L 3.613 mg/L 1.51895931358981 -DTXSID4026268 Css 3compartmentss Human 95% 295.7 mg/L 302.7 mg/L 0.976874793524942 -DTXSID4026422 Css 3compartmentss Human 95% 8.515 mg/L 5.3 mg/L 1.60660377358491 -DTXSID4026472 Css 3compartmentss Human 95% 3.254 mg/L 4.438 mg/L 0.733213159080667 -DTXSID4026505 Css 3compartmentss Human 95% 1.167 mg/L 0.7163 mg/L 1.62920564009493 -DTXSID4026557 Css 3compartmentss Human 95% 0.4991 mg/L 0.3123 mg/L 1.5981428113993 -DTXSID4026684 Css 3compartmentss Human 95% 28.46 mg/L 3.357 mg/L 8.47780756627942 -DTXSID4026921 Css 3compartmentss Human 95% 7.607 mg/L 5.798 mg/L 1.3120041393584 -DTXSID4026927 Css 3compartmentss Human 95% 0.2929 mg/L 0.003058 mg/L 95.7815565729235 -DTXSID4026975 Css 3compartmentss Human 95% 9.258 mg/L 5.546 mg/L 1.6693112152903 -DTXSID4026979 Css 3compartmentss Human 95% 5.874 mg/L 3.791 mg/L 1.54945924558164 -DTXSID4027026 Css 3compartmentss Human 95% 0.1965 mg/L 0.0002455 mg/L 800.40733197556 -DTXSID4027072 Css 3compartmentss Human 95% 0.8524 mg/L 0.6571 mg/L 1.2972150357632 -DTXSID4027076 Css 3compartmentss Human 95% 74.8 mg/L 38.27 mg/L 1.95453357721453 -DTXSID4027103 Css 3compartmentss Human 95% 69.87 mg/L 0.0009002 mg/L 77616.0853143746 -DTXSID4027109 Css 3compartmentss Human 95% 0.04695 mg/L 0.02912 mg/L 1.61229395604396 -DTXSID4027159 Css 3compartmentss Human 95% 5.002 mg/L 3.642 mg/L 1.37342119714443 -DTXSID4027236 Css 3compartmentss Human 95% 1.829 mg/L 1.129 mg/L 1.62001771479185 -DTXSID4027280 Css 3compartmentss Human 95% 7.171 mg/L 1.9e-08 mg/L 377421052.631579 -DTXSID4027284 Css 3compartmentss Human 95% 6.19 mg/L 4.255 mg/L 1.45475910693302 -DTXSID4027286 Css 3compartmentss Human 95% 38.57 mg/L 9739 mg/L 0.00396036554060992 -DTXSID4027319 Css 3compartmentss Human 95% 1.275 mg/L 1.365 mg/L 0.934065934065934 -DTXSID4027361 Css 3compartmentss Human 95% 7.902 mg/L 4.953 mg/L 1.595396729255 -DTXSID4027494 Css 3compartmentss Human 95% 0.3633 mg/L 0.2479 mg/L 1.46551028640581 -DTXSID4027496 Css 3compartmentss Human 95% 31.11 mg/L 17.1 mg/L 1.81929824561403 -DTXSID4027498 Css 3compartmentss Human 95% 28.12 mg/L 17.07 mg/L 1.6473345049795 -DTXSID4027521 Css 3compartmentss Human 95% 1.188 mg/L 0.953 mg/L 1.24658971668416 -DTXSID4027525 Css 3compartmentss Human 95% 11.38 mg/L 6.988 mg/L 1.62850601030338 -DTXSID4027529 Css 3compartmentss Human 95% 6.778 mg/L 4.887 mg/L 1.38694495600573 -DTXSID4027577 Css 3compartmentss Human 95% 8.785 mg/L 5.361 mg/L 1.63868681216191 -DTXSID4027579 Css 3compartmentss Human 95% 5.77 mg/L 3.678 mg/L 1.56878738444807 -DTXSID4027600 Css 3compartmentss Human 95% 9.584 mg/L 5.904 mg/L 1.62330623306233 -DTXSID4027604 Css 3compartmentss Human 95% 162.9 mg/L 91.28 mg/L 1.78461875547765 -DTXSID4027608 Css 3compartmentss Human 95% 2.707 mg/L 1.503 mg/L 1.80106453759148 -DTXSID4027652 Css 3compartmentss Human 95% 8.257 mg/L 5.2 mg/L 1.58788461538462 -DTXSID4027656 Css 3compartmentss Human 95% 10.01 mg/L 6.999 mg/L 1.43020431490213 -DTXSID4027789 Css 3compartmentss Human 95% 5.044 mg/L 3.271 mg/L 1.54203607459493 -DTXSID4027866 Css 3compartmentss Human 95% 48.74 mg/L 28.85 mg/L 1.6894280762565 -DTXSID4027868 Css 3compartmentss Human 95% 28.32 mg/L 1.98 mg/L 14.3030303030303 -DTXSID4027991 Css 3compartmentss Human 95% 8217 mg/L 9739 mg/L 0.843721121265017 -DTXSID4027997 Css 3compartmentss Human 95% 2.529 mg/L 1.68 mg/L 1.50535714285714 -DTXSID4028040 Css 3compartmentss Human 95% 7.271 mg/L 4.13 mg/L 1.76053268765133 -DTXSID4028460 Css 3compartmentss Human 95% 0.1001 mg/L 0.07062 mg/L 1.41744548286604 -DTXSID4028880 Css 3compartmentss Human 95% 0.07497 mg/L 0 mg/L Inf -DTXSID4029062 Css 3compartmentss Human 95% 0.02393 mg/L 0.01441 mg/L 1.66065232477446 -DTXSID4029145 Css 3compartmentss Human 95% 2.752 mg/L 3.401 mg/L 0.809173772419877 -DTXSID4029149 Css 3compartmentss Human 95% 168.8 mg/L 1.931e-05 mg/L 8741584.67115484 -DTXSID4029195 Css 3compartmentss Human 95% 1.266 mg/L 0.8666 mg/L 1.46088160627741 -DTXSID4029220 Css 3compartmentss Human 95% 0.5925 mg/L 0.735 mg/L 0.806122448979592 -DTXSID4029224 Css 3compartmentss Human 95% 5.674 mg/L 3.279 mg/L 1.73040561146691 -DTXSID4029359 Css 3compartmentss Human 95% 3.266 mg/L 2.344 mg/L 1.39334470989761 -DTXSID4029565 Css 3compartmentss Human 95% 0.0004927 mg/L 0 mg/L Inf -DTXSID4029690 Css 3compartmentss Human 95% 6.84 mg/L 4.216 mg/L 1.62239089184061 -DTXSID4029692 Css 3compartmentss Human 95% 18.35 mg/L 27.08 mg/L 0.677621861152142 -DTXSID4029698 Css 3compartmentss Human 95% 6.84 mg/L 4.216 mg/L 1.62239089184061 -DTXSID4029806 Css 3compartmentss Human 95% 32.01 mg/L 11.79 mg/L 2.71501272264631 -DTXSID4030384 Css 3compartmentss Human 95% 2.423 mg/L 2.387 mg/L 1.01508169250105 -DTXSID4031356 Css 3compartmentss Human 95% 6.404 mg/L 3.958 mg/L 1.61798888327438 -DTXSID4031566 Css 3compartmentss Human 95% 1.024 mg/L 0.6177 mg/L 1.65776266796179 -DTXSID4031980 Css 3compartmentss Human 95% 12.12 mg/L 4.901 mg/L 2.47296470108141 -DTXSID4032372 Css 3compartmentss Human 95% 7.968 mg/L 1.843 mg/L 4.32338578404775 -DTXSID4032374 Css 3compartmentss Human 95% 89.02 mg/L 0.03946 mg/L 2255.95539787126 -DTXSID4032376 Css 3compartmentss Human 95% 0.6687 mg/L 0.492 mg/L 1.35914634146341 -DTXSID4032378 Css 3compartmentss Human 95% 137 mg/L 71.82 mg/L 1.90754664438875 -DTXSID4032405 Css 3compartmentss Human 95% 0.4121 mg/L 0.2425 mg/L 1.69938144329897 -DTXSID4032459 Css 3compartmentss Human 95% 596.8 mg/L 482.5 mg/L 1.23689119170984 -DTXSID4032532 Css 3compartmentss Human 95% 0.3526 mg/L 0.178 mg/L 1.98089887640449 -DTXSID4032536 Css 3compartmentss Human 95% 6.068 mg/L 0.003041 mg/L 1995.39625123315 -DTXSID4032580 Css 3compartmentss Human 95% 1.021 mg/L 0.3786 mg/L 2.69677760169044 -DTXSID4032611 Css 3compartmentss Human 95% 4.364 mg/L 2.427 mg/L 1.79810465595385 -DTXSID4032613 Css 3compartmentss Human 95% 10.21 mg/L 5.73 mg/L 1.78184991273997 -DTXSID4032615 Css 3compartmentss Human 95% 47.18 mg/L 25.4 mg/L 1.85748031496063 -DTXSID4032619 Css 3compartmentss Human 95% 20.14 mg/L 12.62 mg/L 1.59587955625991 -DTXSID4032667 Css 3compartmentss Human 95% 12890 mg/L 9603 mg/L 1.34228886806206 -DTXSID4032954 Css 3compartmentss Human 95% 8.184 mg/L 5.11 mg/L 1.60156555772994 -DTXSID4033390 Css 3compartmentss Human 95% 3.159 mg/L 1.67 mg/L 1.89161676646707 -DTXSID4034102 Css 3compartmentss Human 95% 1.127 mg/L 0.549 mg/L 2.0528233151184 -DTXSID4034150 Css 3compartmentss Human 95% 0.4112 mg/L 0.492 mg/L 0.835772357723577 -DTXSID4034287 Css 3compartmentss Human 95% 6.947 mg/L 3.11 mg/L 2.23376205787781 -DTXSID4034364 Css 3compartmentss Human 95% 18.68 mg/L 10.13 mg/L 1.84402764067127 -DTXSID4034497 Css 3compartmentss Human 95% 12.04 mg/L 4.675 mg/L 2.57540106951872 -DTXSID4034528 Css 3compartmentss Human 95% 204.6 mg/L 93.93 mg/L 2.17821782178218 -DTXSID4034576 Css 3compartmentss Human 95% 10.37 mg/L 7.487 mg/L 1.38506745024709 -DTXSID4034601 Css 3compartmentss Human 95% 5.668 mg/L 0.4284 mg/L 13.2306255835668 -DTXSID4034609 Css 3compartmentss Human 95% 163 mg/L 267.1 mg/L 0.610258330213403 -DTXSID4034653 Css 3compartmentss Human 95% 10.52 mg/L 3.77 mg/L 2.79045092838196 -DTXSID4034788 Css 3compartmentss Human 95% 1.318 mg/L 0.7239 mg/L 1.82069346594834 -DTXSID4034869 Css 3compartmentss Human 95% 70.36 mg/L 35.67 mg/L 1.97252593215587 -DTXSID4034948 Css 3compartmentss Human 95% 9.497 mg/L 2.164 mg/L 4.38863216266174 -DTXSID4035209 Css 3compartmentss Human 95% 5.276 mg/L 3.571 mg/L 1.47745729487539 -DTXSID4035542 Css 3compartmentss Human 95% 3.234 mg/L 0.03315 mg/L 97.5565610859729 -DTXSID4035592 Css 3compartmentss Human 95% 69.1 mg/L 0.02421 mg/L 2854.19248244527 -DTXSID4035708 Css 3compartmentss Human 95% 0.4017 mg/L 0.2592 mg/L 1.54976851851852 -DTXSID4036229 Css 3compartmentss Human 95% 5.188 mg/L 2.8 mg/L 1.85285714285714 -DTXSID4036489 Css 3compartmentss Human 95% 4.05 mg/L 2.708 mg/L 1.49556868537666 -DTXSID4036514 Css 3compartmentss Human 95% 10.5 mg/L 0.3861 mg/L 27.1950271950272 -DTXSID4037580 Css 3compartmentss Human 95% 0.007955 mg/L 0.005074 mg/L 1.56779661016949 -DTXSID4037582 Css 3compartmentss Human 95% 0.8318 mg/L 0.5079 mg/L 1.63772396140973 -DTXSID4037584 Css 3compartmentss Human 95% 42.38 mg/L 2.957 mg/L 14.3320933378424 -DTXSID4037617 Css 3compartmentss Human 95% 0.6223 mg/L 0.3404 mg/L 1.82814336075206 -DTXSID4037748 Css 3compartmentss Human 95% 86.28 mg/L 33.67 mg/L 2.56251856251856 -DTXSID4038762 Css 3compartmentss Human 95% 1.112 mg/L 0.7937 mg/L 1.40103313594557 -DTXSID4038847 Css 3compartmentss Human 95% 1.008 mg/L 0.5652 mg/L 1.78343949044586 -DTXSID4038899 Css 3compartmentss Human 95% 7.793 mg/L 9.953e-06 mg/L 782980.006028333 -DTXSID4038922 Css 3compartmentss Human 95% 57.99 mg/L 0.1143 mg/L 507.349081364829 -DTXSID4038926 Css 3compartmentss Human 95% 3.841 mg/L 1.631 mg/L 2.35499693439608 -DTXSID4039235 Css 3compartmentss Human 95% 47.08 mg/L 25.46 mg/L 1.84917517674784 -DTXSID4039657 Css 3compartmentss Human 95% 6.266 mg/L 4.07 mg/L 1.53955773955774 -DTXSID4040002 Css 3compartmentss Human 95% 13.83 mg/L 8.712 mg/L 1.58746556473829 -DTXSID4040187 Css 3compartmentss Human 95% 5.085 mg/L 2.884 mg/L 1.76317614424411 -DTXSID4040264 Css 3compartmentss Human 95% 1933 mg/L 2100 mg/L 0.92047619047619 -DTXSID4040266 Css 3compartmentss Human 95% 10.53 mg/L 7.658 mg/L 1.37503264559937 -DTXSID4040268 Css 3compartmentss Human 95% 0.5209 mg/L 0.3035 mg/L 1.7163097199341 -DTXSID4040343 Css 3compartmentss Human 95% 11.48 mg/L 9.747 mg/L 1.17779829691187 -DTXSID4040395 Css 3compartmentss Human 95% 0.2507 mg/L 0.1646 mg/L 1.52308626974484 -DTXSID4040476 Css 3compartmentss Human 95% 7.155 mg/L 0.03263 mg/L 219.276739197058 -DTXSID4040682 Css 3compartmentss Human 95% 10.22 mg/L 6.122 mg/L 1.66938908853316 -DTXSID4040684 Css 3compartmentss Human 95% 0.5037 mg/L 0.1159 mg/L 4.34598792062123 -DTXSID4040686 Css 3compartmentss Human 95% 109.1 mg/L 68.24 mg/L 1.59876905041032 -DTXSID4040688 Css 3compartmentss Human 95% 11.02 mg/L 6.709 mg/L 1.64256968251602 -DTXSID4040711 Css 3compartmentss Human 95% 0.6097 mg/L 0.4912 mg/L 1.24124592833876 -DTXSID4040715 Css 3compartmentss Human 95% 0.5914 mg/L 0.5107 mg/L 1.15801840610926 -DTXSID4040719 Css 3compartmentss Human 95% 1.824 mg/L 1.121 mg/L 1.6271186440678 -DTXSID4040765 Css 3compartmentss Human 95% 0.01012 mg/L 0.009392 mg/L 1.07751277683135 -DTXSID4040767 Css 3compartmentss Human 95% 13950 mg/L 7881 mg/L 1.77007993909402 -DTXSID4040979 Css 3compartmentss Human 95% 0.7459 mg/L 0.2962 mg/L 2.51823092505064 -DTXSID4041070 Css 3compartmentss Human 95% 18.72 mg/L 7.113 mg/L 2.63180092787853 -DTXSID4041074 Css 3compartmentss Human 95% 5.192 mg/L 3.33 mg/L 1.55915915915916 -DTXSID4041230 Css 3compartmentss Human 95% 0.2849 mg/L 0.1372 mg/L 2.0765306122449 -DTXSID4041234 Css 3compartmentss Human 95% 2.352 mg/L 1.488 mg/L 1.58064516129032 -DTXSID4041238 Css 3compartmentss Human 95% 0.2348 mg/L 0.1745 mg/L 1.34555873925501 -DTXSID4041280 Css 3compartmentss Human 95% 0.2183 mg/L 0.1755 mg/L 1.24387464387464 -DTXSID4041361 Css 3compartmentss Human 95% 5.883 mg/L 3.637 mg/L 1.61754193016222 -DTXSID4041363 Css 3compartmentss Human 95% 60.14 mg/L 33.03 mg/L 1.82076899788071 -DTXSID4041367 Css 3compartmentss Human 95% 3.635 mg/L 2.104 mg/L 1.72766159695817 -DTXSID4041442 Css 3compartmentss Human 95% 11.45 mg/L 6.076 mg/L 1.88446346280448 -DTXSID4041446 Css 3compartmentss Human 95% 3.005 mg/L 2.487 mg/L 1.20828307197427 -DTXSID4041490 Css 3compartmentss Human 95% 3.341 mg/L 3.707 mg/L 0.901267871594281 -DTXSID4041494 Css 3compartmentss Human 95% 39.08 mg/L 1.316 mg/L 29.6960486322188 -DTXSID4041521 Css 3compartmentss Human 95% 1.54 mg/L 1.08 mg/L 1.42592592592593 -DTXSID4041527 Css 3compartmentss Human 95% 1.543 mg/L 1.089 mg/L 1.41689623507805 -DTXSID4041529 Css 3compartmentss Human 95% 1.012 mg/L 0.5941 mg/L 1.70341693317623 -DTXSID4041573 Css 3compartmentss Human 95% 0.1414 mg/L 0.08393 mg/L 1.68473728106756 -DTXSID4041575 Css 3compartmentss Human 95% 3.868 mg/L 2.015 mg/L 1.91960297766749 -DTXSID4041600 Css 3compartmentss Human 95% 0.838 mg/L 0.4428 mg/L 1.89250225835592 -DTXSID4041654 Css 3compartmentss Human 95% 12.71 mg/L 1.947 mg/L 6.52799178222907 -DTXSID4041656 Css 3compartmentss Human 95% 163 mg/L 94.02 mg/L 1.73367368644969 -DTXSID4041783 Css 3compartmentss Human 95% 1.544 mg/L 0.9567 mg/L 1.61388104944079 -DTXSID4041812 Css 3compartmentss Human 95% 8.723 mg/L 9.877 mg/L 0.883162903715703 -DTXSID4041995 Css 3compartmentss Human 95% 10.13 mg/L 6.453 mg/L 1.56981249031458 -DTXSID4041997 Css 3compartmentss Human 95% 0.4124 mg/L 0.2542 mg/L 1.62234461054288 -DTXSID4042090 Css 3compartmentss Human 95% 51.63 mg/L 4.676 mg/L 11.0414884516681 -DTXSID4042094 Css 3compartmentss Human 95% 12.27 mg/L 1.012 mg/L 12.1245059288538 -DTXSID4042096 Css 3compartmentss Human 95% 5.575 mg/L 3.628 mg/L 1.53665931642778 -DTXSID4042121 Css 3compartmentss Human 95% 172.1 mg/L 180.3 mg/L 0.954520244037715 -DTXSID4042123 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID4042129 Css 3compartmentss Human 95% 13.75 mg/L 3.532 mg/L 3.89297848244621 -DTXSID4042171 Css 3compartmentss Human 95% 2.973 mg/L 0.7374 mg/L 4.03173311635476 -DTXSID4042206 Css 3compartmentss Human 95% 17.4 mg/L 4.457 mg/L 3.90397128113081 -DTXSID4042208 Css 3compartmentss Human 95% 2.398 mg/L 1.323 mg/L 1.81254724111867 -DTXSID4042252 Css 3compartmentss Human 95% 0.7241 mg/L 0.4756 mg/L 1.52249789739277 -DTXSID4042254 Css 3compartmentss Human 95% 630.2 mg/L 1160 mg/L 0.543275862068966 -DTXSID4042256 Css 3compartmentss Human 95% 36.14 mg/L 12.58 mg/L 2.87281399046105 -DTXSID4042335 Css 3compartmentss Human 95% 7.282 mg/L 5.792 mg/L 1.25725138121547 -DTXSID4042416 Css 3compartmentss Human 95% 146.5 mg/L 76.61 mg/L 1.91228299177653 -DTXSID4042418 Css 3compartmentss Human 95% 6.389 mg/L 3.323 mg/L 1.92266024676497 -DTXSID4042468 Css 3compartmentss Human 95% 0.1817 mg/L 0.1262 mg/L 1.43977812995246 -DTXSID4042622 Css 3compartmentss Human 95% 6.793 mg/L 3.352 mg/L 2.02655131264916 -DTXSID4043777 Css 3compartmentss Human 95% 0.6736 mg/L 0.4825 mg/L 1.3960621761658 -DTXSID4043802 Css 3compartmentss Human 95% 3.664 mg/L 3.053 mg/L 1.20013101867016 -DTXSID4043850 Css 3compartmentss Human 95% 1.726 mg/L 1.136 mg/L 1.5193661971831 -DTXSID4043937 Css 3compartmentss Human 95% 5.559 mg/L 3.261 mg/L 1.70469181232751 -DTXSID4044161 Css 3compartmentss Human 95% 14.41 mg/L 19.81 mg/L 0.727410398788491 -DTXSID4044371 Css 3compartmentss Human 95% 2.574 mg/L 1.554 mg/L 1.65637065637066 -DTXSID4044373 Css 3compartmentss Human 95% 2.823 mg/L 2.141 mg/L 1.31854273703877 -DTXSID4044375 Css 3compartmentss Human 95% 2.822 mg/L 3.327 mg/L 0.848211602043883 -DTXSID4044379 Css 3compartmentss Human 95% 48.87 mg/L 113 mg/L 0.432477876106195 -DTXSID4044402 Css 3compartmentss Human 95% 1.53 mg/L 1.01 mg/L 1.51485148514851 -DTXSID4044404 Css 3compartmentss Human 95% 1.084 mg/L 0.7198 mg/L 1.50597388163379 -DTXSID4044408 Css 3compartmentss Human 95% 4.283 mg/L 2.976 mg/L 1.43918010752688 -DTXSID4044454 Css 3compartmentss Human 95% 4.777 mg/L 2.952 mg/L 1.61822493224932 -DTXSID4044456 Css 3compartmentss Human 95% 5.076 mg/L 3.282 mg/L 1.54661791590494 -DTXSID4044458 Css 3compartmentss Human 95% 4.843 mg/L 2.151 mg/L 2.25151092515109 -DTXSID4044535 Css 3compartmentss Human 95% 90.69 mg/L 51.55 mg/L 1.75926285160039 -DTXSID4044537 Css 3compartmentss Human 95% 165.2 mg/L 75.65 mg/L 2.18374091209517 -DTXSID4044581 Css 3compartmentss Human 95% 1.277 mg/L 0.4297 mg/L 2.97184081917617 -DTXSID4044585 Css 3compartmentss Human 95% 7.374 mg/L 4.101 mg/L 1.79809802487198 -DTXSID4044589 Css 3compartmentss Human 95% 7.406 mg/L 4.556 mg/L 1.62554872695347 -DTXSID4044618 Css 3compartmentss Human 95% 0.5588 mg/L 0.5047 mg/L 1.10719239151971 -DTXSID4044660 Css 3compartmentss Human 95% 1.183 mg/L 0.7658 mg/L 1.54478976234004 -DTXSID4044664 Css 3compartmentss Human 95% 1.458 mg/L 0.9126 mg/L 1.59763313609467 -DTXSID4044668 Css 3compartmentss Human 95% 29.15 mg/L 19.07 mg/L 1.52857891976927 -DTXSID4044743 Css 3compartmentss Human 95% 13.96 mg/L 8.512 mg/L 1.64003759398496 -DTXSID4044745 Css 3compartmentss Human 95% 6.239 mg/L 4.714 mg/L 1.32350445481544 -DTXSID4044747 Css 3compartmentss Human 95% 1.962 mg/L 1.674 mg/L 1.17204301075269 -DTXSID4044793 Css 3compartmentss Human 95% 3.217 mg/L 1.834 mg/L 1.75408942202835 -DTXSID4044799 Css 3compartmentss Human 95% 3.565 mg/L 3.133 mg/L 1.1378870092563 -DTXSID4044820 Css 3compartmentss Human 95% 1.133 mg/L 0.6472 mg/L 1.75061804697157 -DTXSID4044822 Css 3compartmentss Human 95% 6.544 mg/L 2.572 mg/L 2.5443234836703 -DTXSID4044824 Css 3compartmentss Human 95% 9.577 mg/L 10.32 mg/L 0.928003875968992 -DTXSID4044870 Css 3compartmentss Human 95% 6.168 mg/L 4.985 mg/L 1.23731193580742 -DTXSID4044872 Css 3compartmentss Human 95% 11.37 mg/L 6.012 mg/L 1.89121756487026 -DTXSID4044874 Css 3compartmentss Human 95% 0.01465 mg/L 0.00688 mg/L 2.12936046511628 -DTXSID4044876 Css 3compartmentss Human 95% 5.48 mg/L 3.633 mg/L 1.5083952656207 -DTXSID4044901 Css 3compartmentss Human 95% 9.156 mg/L 6.085 mg/L 1.50468364831553 -DTXSID4044903 Css 3compartmentss Human 95% 0.2504 mg/L 0.005896 mg/L 42.4694708276798 -DTXSID4044905 Css 3compartmentss Human 95% 0.4224 mg/L 0.2869 mg/L 1.47228999651447 -DTXSID4044951 Css 3compartmentss Human 95% 7.198 mg/L 4.364 mg/L 1.64940421631531 -DTXSID4044953 Css 3compartmentss Human 95% 1.205 mg/L 0.8885 mg/L 1.35621834552617 -DTXSID4044955 Css 3compartmentss Human 95% 7.909 mg/L 4.826 mg/L 1.63883133029424 -DTXSID4045002 Css 3compartmentss Human 95% 0.9215 mg/L 0.5326 mg/L 1.73019151333083 -DTXSID4045131 Css 3compartmentss Human 95% 0.06531 mg/L 0.04745 mg/L 1.37639620653319 -DTXSID4045133 Css 3compartmentss Human 95% 11.48 mg/L 6.975 mg/L 1.64587813620072 -DTXSID4045139 Css 3compartmentss Human 95% 5.834 mg/L 3.708 mg/L 1.57335490830636 -DTXSID4045181 Css 3compartmentss Human 95% 3.997 mg/L 0.7729 mg/L 5.17143226808125 -DTXSID4045183 Css 3compartmentss Human 95% 3.526 mg/L 2.213 mg/L 1.59331224582015 -DTXSID4045187 Css 3compartmentss Human 95% 36.01 mg/L 1.977 mg/L 18.2144663631765 -DTXSID4045189 Css 3compartmentss Human 95% 1.877 mg/L 1.136 mg/L 1.65228873239437 -DTXSID4045210 Css 3compartmentss Human 95% 0.277 mg/L 0.2001 mg/L 1.38430784607696 -DTXSID4045216 Css 3compartmentss Human 95% 16.74 mg/L 10.06 mg/L 1.66401590457256 -DTXSID4045262 Css 3compartmentss Human 95% 5.624 mg/L 4.15 mg/L 1.35518072289157 -DTXSID4045341 Css 3compartmentss Human 95% 0.3018 mg/L 0.2485 mg/L 1.21448692152918 -DTXSID4045343 Css 3compartmentss Human 95% 9.688 mg/L 5.285 mg/L 1.83311258278146 -DTXSID4045345 Css 3compartmentss Human 95% 2.302 mg/L 1.651 mg/L 1.39430648092065 -DTXSID4045347 Css 3compartmentss Human 95% 18.59 mg/L 3.214 mg/L 5.78406969508401 -DTXSID4045391 Css 3compartmentss Human 95% 4.941 mg/L 3.323 mg/L 1.48690941919952 -DTXSID4045393 Css 3compartmentss Human 95% 0.3345 mg/L 0.1977 mg/L 1.69195751138088 -DTXSID4045399 Css 3compartmentss Human 95% 14.62 mg/L 1.263 mg/L 11.575613618369 -DTXSID4045420 Css 3compartmentss Human 95% 0.7488 mg/L 0.5209 mg/L 1.4375119984642 -DTXSID4045422 Css 3compartmentss Human 95% 0.08712 mg/L 0.05012 mg/L 1.73822825219473 -DTXSID4045424 Css 3compartmentss Human 95% 11.78 mg/L 6.615 mg/L 1.78080120937264 -DTXSID4045428 Css 3compartmentss Human 95% 1.857 mg/L 1.268 mg/L 1.46451104100946 -DTXSID4045472 Css 3compartmentss Human 95% 1.006 mg/L 0.6857 mg/L 1.46711389820621 -DTXSID4045474 Css 3compartmentss Human 95% 7.478 mg/L 4.329 mg/L 1.72741972741973 -DTXSID4045476 Css 3compartmentss Human 95% 5.524 mg/L 2.503 mg/L 2.20695165801039 -DTXSID4045478 Css 3compartmentss Human 95% 0.06372 mg/L 0.0414 mg/L 1.53913043478261 -DTXSID4045551 Css 3compartmentss Human 95% 39.69 mg/L 21.82 mg/L 1.81897341888176 -DTXSID4045555 Css 3compartmentss Human 95% 1.611 mg/L 1.074 mg/L 1.5 -DTXSID4045557 Css 3compartmentss Human 95% 2.574 mg/L 0.3766 mg/L 6.8348380244291 -DTXSID4045559 Css 3compartmentss Human 95% 1.504 mg/L 0.8461 mg/L 1.77756766339676 -DTXSID4045630 Css 3compartmentss Human 95% 2.547 mg/L 1.695 mg/L 1.50265486725664 -DTXSID4045632 Css 3compartmentss Human 95% 0.3334 mg/L 0.2641 mg/L 1.26240060583112 -DTXSID4045636 Css 3compartmentss Human 95% 20.34 mg/L 11.84 mg/L 1.71790540540541 -DTXSID4045638 Css 3compartmentss Human 95% 0.1385 mg/L 0.01106 mg/L 12.5226039783002 -DTXSID4045680 Css 3compartmentss Human 95% 229.7 mg/L 126.4 mg/L 1.81724683544304 -DTXSID4045682 Css 3compartmentss Human 95% 0.7205 mg/L 0.4537 mg/L 1.58805378003086 -DTXSID4045686 Css 3compartmentss Human 95% 0.2025 mg/L 0.1358 mg/L 1.49116347569956 -DTXSID4045688 Css 3compartmentss Human 95% 1.166 mg/L 0.8288 mg/L 1.40685328185328 -DTXSID4045711 Css 3compartmentss Human 95% 3.12 mg/L 1.345 mg/L 2.31970260223048 -DTXSID4045763 Css 3compartmentss Human 95% 0.8381 mg/L 0.59 mg/L 1.42050847457627 -DTXSID4045765 Css 3compartmentss Human 95% 2.363 mg/L 1.518 mg/L 1.5566534914361 -DTXSID4045767 Css 3compartmentss Human 95% 3.954 mg/L 1.634 mg/L 2.41982864137087 -DTXSID4045769 Css 3compartmentss Human 95% 32.87 mg/L 19.38 mg/L 1.69607843137255 -DTXSID4045846 Css 3compartmentss Human 95% 2.546 mg/L 1.41 mg/L 1.80567375886525 -DTXSID4045848 Css 3compartmentss Human 95% 0.8882 mg/L 0.5568 mg/L 1.5951867816092 -DTXSID4045890 Css 3compartmentss Human 95% 0.4231 mg/L 0.2878 mg/L 1.47011813759555 -DTXSID4045892 Css 3compartmentss Human 95% 12.38 mg/L 8.032 mg/L 1.54133466135458 -DTXSID4045896 Css 3compartmentss Human 95% 1.213 mg/L 0.6741 mg/L 1.79943628541759 -DTXSID4045898 Css 3compartmentss Human 95% 10.76 mg/L 5.354 mg/L 2.00971236458722 -DTXSID4045921 Css 3compartmentss Human 95% 1.829 mg/L 1.537 mg/L 1.18998048145738 -DTXSID4045925 Css 3compartmentss Human 95% 6.452 mg/L 3.996 mg/L 1.61461461461461 -DTXSID4045927 Css 3compartmentss Human 95% 21.22 mg/L 0.1074 mg/L 197.579143389199 -DTXSID4045929 Css 3compartmentss Human 95% 8.447 mg/L 5.463 mg/L 1.54622002562694 -DTXSID4045973 Css 3compartmentss Human 95% 4.515 mg/L 2.712 mg/L 1.66482300884956 -DTXSID4045975 Css 3compartmentss Human 95% 9.739 mg/L 2.981 mg/L 3.2670244884267 -DTXSID4045979 Css 3compartmentss Human 95% 5.553 mg/L 3.628 mg/L 1.5305953693495 -DTXSID4046020 Css 3compartmentss Human 95% 0.4784 mg/L 0.3031 mg/L 1.57835697789508 -DTXSID4046022 Css 3compartmentss Human 95% 3.373 mg/L 2.18 mg/L 1.54724770642202 -DTXSID4046024 Css 3compartmentss Human 95% 11.49 mg/L 5.133 mg/L 2.23845704266511 -DTXSID4046076 Css 3compartmentss Human 95% 1.956 mg/L 1.007 mg/L 1.94240317775571 -DTXSID4046078 Css 3compartmentss Human 95% 0.09334 mg/L 0.06562 mg/L 1.42243218530936 -DTXSID4046101 Css 3compartmentss Human 95% 49.01 mg/L 17.72 mg/L 2.76580135440181 -DTXSID4046103 Css 3compartmentss Human 95% 65.46 mg/L 33.66 mg/L 1.94474153297683 -DTXSID4046107 Css 3compartmentss Human 95% 0.7727 mg/L 0.4594 mg/L 1.68197649107532 -DTXSID4046109 Css 3compartmentss Human 95% 4.43 mg/L 2.778 mg/L 1.5946724262059 -DTXSID4046151 Css 3compartmentss Human 95% 1003 mg/L 562.2 mg/L 1.7840626111704 -DTXSID4046153 Css 3compartmentss Human 95% 10.05 mg/L 6.222 mg/L 1.6152362584378 -DTXSID4046155 Css 3compartmentss Human 95% 94.98 mg/L 52.81 mg/L 1.79852300700625 -DTXSID4046157 Css 3compartmentss Human 95% 393 mg/L 228.7 mg/L 1.71840839527766 -DTXSID4046159 Css 3compartmentss Human 95% 1.355 mg/L 0.9035 mg/L 1.49972329828445 -DTXSID4046230 Css 3compartmentss Human 95% 2.145 mg/L 1.092 mg/L 1.96428571428571 -DTXSID4046232 Css 3compartmentss Human 95% 0.2892 mg/L 0.2306 mg/L 1.25411968777103 -DTXSID4046234 Css 3compartmentss Human 95% 6.39 mg/L 3.797 mg/L 1.68290755859889 -DTXSID4046236 Css 3compartmentss Human 95% 1.948 mg/L 1.169 mg/L 1.66638152266895 -DTXSID4046280 Css 3compartmentss Human 95% 5.075 mg/L 0.4111 mg/L 12.3449282413038 -DTXSID4046282 Css 3compartmentss Human 95% 170.8 mg/L 93.69 mg/L 1.82303340804782 -DTXSID4046284 Css 3compartmentss Human 95% 54.77 mg/L 31.71 mg/L 1.72721538946705 -DTXSID4046286 Css 3compartmentss Human 95% 11.39 mg/L 6.177 mg/L 1.84393718633641 -DTXSID4046288 Css 3compartmentss Human 95% 2.029 mg/L 1.388 mg/L 1.46181556195965 -DTXSID4046313 Css 3compartmentss Human 95% 0.3248 mg/L 0.2788 mg/L 1.16499282639885 -DTXSID4046315 Css 3compartmentss Human 95% 3.81 mg/L 2.753 mg/L 1.38394478750454 -DTXSID4046319 Css 3compartmentss Human 95% 0.06309 mg/L 0.04286 mg/L 1.47200186654223 -DTXSID4046361 Css 3compartmentss Human 95% 0.1688 mg/L 0.1282 mg/L 1.31669266770671 -DTXSID4046363 Css 3compartmentss Human 95% 99.6 mg/L 59.85 mg/L 1.66416040100251 -DTXSID4046440 Css 3compartmentss Human 95% 5.571 mg/L 2.139 mg/L 2.60448807854137 -DTXSID4046442 Css 3compartmentss Human 95% 2.206 mg/L 0.8164 mg/L 2.70210681038707 -DTXSID4046444 Css 3compartmentss Human 95% 7.333 mg/L 5.001 mg/L 1.46630673865227 -DTXSID4046446 Css 3compartmentss Human 95% 5.641 mg/L 3.82 mg/L 1.47670157068063 -DTXSID4046448 Css 3compartmentss Human 95% 57.79 mg/L 9.973 mg/L 5.79464554296601 -DTXSID4046490 Css 3compartmentss Human 95% 0.387 mg/L 0.2317 mg/L 1.67026327147173 -DTXSID4046492 Css 3compartmentss Human 95% 0.2262 mg/L 0.1432 mg/L 1.57960893854749 -DTXSID4046494 Css 3compartmentss Human 95% 20.69 mg/L 33.48 mg/L 0.617980884109916 -DTXSID4046498 Css 3compartmentss Human 95% 28.18 mg/L 17.14 mg/L 1.6441073512252 -DTXSID4046521 Css 3compartmentss Human 95% 28.21 mg/L 17.06 mg/L 1.65357561547479 -DTXSID4046523 Css 3compartmentss Human 95% 10.94 mg/L 6.522 mg/L 1.67739957068384 -DTXSID4046525 Css 3compartmentss Human 95% 0.5022 mg/L 0.3424 mg/L 1.46670560747664 -DTXSID4046527 Css 3compartmentss Human 95% 4.759 mg/L 2.952 mg/L 1.61212737127371 -DTXSID4046529 Css 3compartmentss Human 95% 0.286 mg/L 0.1607 mg/L 1.77971375233354 -DTXSID4046571 Css 3compartmentss Human 95% 6.157 mg/L 3.563 mg/L 1.72803817008139 -DTXSID4046573 Css 3compartmentss Human 95% 75.69 mg/L 44.97 mg/L 1.68312208138759 -DTXSID4046575 Css 3compartmentss Human 95% 8.982 mg/L 6.061 mg/L 1.48193367431117 -DTXSID4046577 Css 3compartmentss Human 95% 49.04 mg/L 29.84 mg/L 1.64343163538874 -DTXSID4046579 Css 3compartmentss Human 95% 0.5073 mg/L 0.324 mg/L 1.56574074074074 -DTXSID4046600 Css 3compartmentss Human 95% 0.6979 mg/L 0.422 mg/L 1.65379146919431 -DTXSID4046602 Css 3compartmentss Human 95% 5.183 mg/L 3.132 mg/L 1.65485312899106 -DTXSID4046604 Css 3compartmentss Human 95% 5.011 mg/L 3.131 mg/L 1.60044714148834 -DTXSID4046606 Css 3compartmentss Human 95% 0.4263 mg/L 0.001456 mg/L 292.788461538462 -DTXSID4046608 Css 3compartmentss Human 95% 0.788 mg/L 0.2581 mg/L 3.0530802014723 -DTXSID4046652 Css 3compartmentss Human 95% 0.2757 mg/L 0.196 mg/L 1.40663265306122 -DTXSID4046654 Css 3compartmentss Human 95% 2.306 mg/L 1.343 mg/L 1.71705137751303 -DTXSID4046656 Css 3compartmentss Human 95% 0.09796 mg/L 0.06187 mg/L 1.58331986423145 -DTXSID4046658 Css 3compartmentss Human 95% 0.8218 mg/L 0.3891 mg/L 2.11205345669494 -DTXSID4046733 Css 3compartmentss Human 95% 0.3359 mg/L 0.2479 mg/L 1.35498184751916 -DTXSID4046735 Css 3compartmentss Human 95% 157.5 mg/L 88.14 mg/L 1.78692988427502 -DTXSID4046737 Css 3compartmentss Human 95% 22.67 mg/L 9.126 mg/L 2.48411133026518 -DTXSID4046739 Css 3compartmentss Human 95% 0.09303 mg/L 0.05294 mg/L 1.75727238383075 -DTXSID4046783 Css 3compartmentss Human 95% 7.054 mg/L 4.482 mg/L 1.57385095939313 -DTXSID4046785 Css 3compartmentss Human 95% 0.3003 mg/L 0.2144 mg/L 1.40065298507463 -DTXSID4046787 Css 3compartmentss Human 95% 148.9 mg/L 53.12 mg/L 2.80308734939759 -DTXSID4046810 Css 3compartmentss Human 95% 7.449 mg/L 4.037 mg/L 1.84518206589051 -DTXSID4046812 Css 3compartmentss Human 95% 45.32 mg/L 0.2697 mg/L 168.038561364479 -DTXSID4046814 Css 3compartmentss Human 95% 8.313 mg/L 5.248 mg/L 1.58403201219512 -DTXSID4046816 Css 3compartmentss Human 95% 2444 mg/L 9739 mg/L 0.250949789506109 -DTXSID4046818 Css 3compartmentss Human 95% 1.851 mg/L 1.379 mg/L 1.34227701232777 -DTXSID4046862 Css 3compartmentss Human 95% 0.7889 mg/L 0.4854 mg/L 1.62525751957149 -DTXSID4046864 Css 3compartmentss Human 95% 7.424 mg/L 4.838 mg/L 1.53451839603142 -DTXSID4046866 Css 3compartmentss Human 95% 10.31 mg/L 6.621 mg/L 1.55716659114937 -DTXSID4046868 Css 3compartmentss Human 95% 0.1817 mg/L 0.1058 mg/L 1.71739130434783 -DTXSID4046949 Css 3compartmentss Human 95% 30.7 mg/L 1.705 mg/L 18.0058651026393 -DTXSID4046991 Css 3compartmentss Human 95% 7.897 mg/L 4.867 mg/L 1.62256009862338 -DTXSID4046999 Css 3compartmentss Human 95% 15.18 mg/L 8.594 mg/L 1.76634861531301 -DTXSID4047040 Css 3compartmentss Human 95% 26.06 mg/L 14.52 mg/L 1.79476584022039 -DTXSID4047044 Css 3compartmentss Human 95% 164.4 mg/L 0.2993 mg/L 549.281657200134 -DTXSID4047090 Css 3compartmentss Human 95% 3.202 mg/L 2.297 mg/L 1.39399216369177 -DTXSID4047094 Css 3compartmentss Human 95% 3.402 mg/L 2.309 mg/L 1.4733650931139 -DTXSID4047096 Css 3compartmentss Human 95% 1.415 mg/L 0.9424 mg/L 1.50148556876061 -DTXSID4047121 Css 3compartmentss Human 95% 0.9766 mg/L 0.6717 mg/L 1.4539228822391 -DTXSID4047173 Css 3compartmentss Human 95% 2.315 mg/L 1.404 mg/L 1.6488603988604 -DTXSID4047179 Css 3compartmentss Human 95% 2.766e-06 mg/L NA NA NA -DTXSID4047252 Css 3compartmentss Human 95% 43.61 mg/L 24.37 mg/L 1.7894952810833 -DTXSID4047254 Css 3compartmentss Human 95% 2.937 mg/L 1.638 mg/L 1.79304029304029 -DTXSID4047258 Css 3compartmentss Human 95% 1.125 mg/L 0.9209 mg/L 1.22163101313932 -DTXSID4047331 Css 3compartmentss Human 95% 7780 mg/L 8561 mg/L 0.908772339679944 -DTXSID4047333 Css 3compartmentss Human 95% 238.2 mg/L 186.2 mg/L 1.27926960257787 -DTXSID4047335 Css 3compartmentss Human 95% 3.705 mg/L 0.9283 mg/L 3.9911666487127 -DTXSID4047337 Css 3compartmentss Human 95% 74.21 mg/L 8.375 mg/L 8.86089552238806 -DTXSID4047339 Css 3compartmentss Human 95% 2.595 mg/L 0.4094 mg/L 6.33854421104055 -DTXSID4047381 Css 3compartmentss Human 95% 3.419 mg/L 1.773 mg/L 1.92836999435984 -DTXSID4047385 Css 3compartmentss Human 95% 1.028 mg/L 0.8897 mg/L 1.15544565583905 -DTXSID4047387 Css 3compartmentss Human 95% 5.838 mg/L 0.04286 mg/L 136.210919272049 -DTXSID4047389 Css 3compartmentss Human 95% 280.4 mg/L 664.1 mg/L 0.422225568438488 -DTXSID4047410 Css 3compartmentss Human 95% 11.46 mg/L 0.001383 mg/L 8286.33405639913 -DTXSID4047412 Css 3compartmentss Human 95% 0.4695 mg/L 0.3824 mg/L 1.2277719665272 -DTXSID4047464 Css 3compartmentss Human 95% 3.429 mg/L 2.365 mg/L 1.44989429175476 -DTXSID4047466 Css 3compartmentss Human 95% 3.305 mg/L 2.332 mg/L 1.4172384219554 -DTXSID4047468 Css 3compartmentss Human 95% 2.572 mg/L 1.625 mg/L 1.58276923076923 -DTXSID4047543 Css 3compartmentss Human 95% 4.655 mg/L 2.792 mg/L 1.66726361031519 -DTXSID4047545 Css 3compartmentss Human 95% 106.7 mg/L 55.73 mg/L 1.91458819307375 -DTXSID4047547 Css 3compartmentss Human 95% 1.564 mg/L 1.092 mg/L 1.43223443223443 -DTXSID4047549 Css 3compartmentss Human 95% 5.087 mg/L 3.103 mg/L 1.63938124395746 -DTXSID4047597 Css 3compartmentss Human 95% 5.128 mg/L 2.208 mg/L 2.32246376811594 -DTXSID4047620 Css 3compartmentss Human 95% 1.655 mg/L 0.6552 mg/L 2.52594627594628 -DTXSID4047622 Css 3compartmentss Human 95% 16.36 mg/L 0.006318 mg/L 2589.42703387148 -DTXSID4047624 Css 3compartmentss Human 95% 90.34 mg/L 0.1282 mg/L 704.680187207488 -DTXSID4047670 Css 3compartmentss Human 95% 0.5592 mg/L 0.3891 mg/L 1.43716268311488 -DTXSID4047672 Css 3compartmentss Human 95% 6.889 mg/L 0.1136 mg/L 60.6426056338028 -DTXSID4047674 Css 3compartmentss Human 95% 6.269 mg/L 4.007 mg/L 1.56451210381832 -DTXSID4047678 Css 3compartmentss Human 95% 1.38 mg/L 1.028 mg/L 1.34241245136187 -DTXSID4047703 Css 3compartmentss Human 95% 1.475 mg/L 0.9062 mg/L 1.62767600971088 -DTXSID4047705 Css 3compartmentss Human 95% 4.17 mg/L 2.236 mg/L 1.8649373881932 -DTXSID4047707 Css 3compartmentss Human 95% 1.934 mg/L 1.342 mg/L 1.44113263785395 -DTXSID4047709 Css 3compartmentss Human 95% 5.398 mg/L 3.516 mg/L 1.53526734926052 -DTXSID4047838 Css 3compartmentss Human 95% 2.36 mg/L 2.635 mg/L 0.895635673624288 -DTXSID4047880 Css 3compartmentss Human 95% 3.476 mg/L 1.964 mg/L 1.76985743380855 -DTXSID4047882 Css 3compartmentss Human 95% 0.1327 mg/L 0.05698 mg/L 2.32888732888733 -DTXSID4047886 Css 3compartmentss Human 95% 1.059 mg/L 0.6108 mg/L 1.73379174852652 -DTXSID4047888 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID4047913 Css 3compartmentss Human 95% 0.08167 mg/L 0.05061 mg/L 1.61371270499901 -DTXSID4047917 Css 3compartmentss Human 95% 0.09565 mg/L 0.05363 mg/L 1.78351668842066 -DTXSID4047919 Css 3compartmentss Human 95% 2.326 mg/L 0.2671 mg/L 8.7083489329839 -DTXSID4047961 Css 3compartmentss Human 95% 9.36 mg/L 3.821 mg/L 2.44962051818896 -DTXSID4047963 Css 3compartmentss Human 95% 68.67 mg/L 22.26 mg/L 3.08490566037736 -DTXSID4047967 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID4047969 Css 3compartmentss Human 95% 24.16 mg/L 14.11 mg/L 1.71226080793763 -DTXSID4048191 Css 3compartmentss Human 95% 46.32 mg/L 3.493 mg/L 13.2608073289436 -DTXSID4048193 Css 3compartmentss Human 95% 0.1183 mg/L 0 mg/L Inf -DTXSID4048195 Css 3compartmentss Human 95% 110 mg/L 42.47 mg/L 2.59006357428773 -DTXSID4048199 Css 3compartmentss Human 95% 0.5994 mg/L 0.3702 mg/L 1.61912479740681 -DTXSID4048270 Css 3compartmentss Human 95% 11.45 mg/L 6.431 mg/L 1.78043850101073 -DTXSID4048511 Css 3compartmentss Human 95% 0.5124 mg/L 0.3033 mg/L 1.68941641938675 -DTXSID4048513 Css 3compartmentss Human 95% 5.471 mg/L 0.00362 mg/L 1511.32596685083 -DTXSID4048519 Css 3compartmentss Human 95% 2.011 mg/L 0.8403 mg/L 2.39319290729501 -DTXSID4048640 Css 3compartmentss Human 95% 1.647 mg/L 0.003326 mg/L 495.189416716777 -DTXSID4048644 Css 3compartmentss Human 95% 1.306 mg/L 0.8519 mg/L 1.53304378448175 -DTXSID4048646 Css 3compartmentss Human 95% 4.916 mg/L 2.731 mg/L 1.80007323324789 -DTXSID4048648 Css 3compartmentss Human 95% 0.3744 mg/L 0.0724 mg/L 5.17127071823204 -DTXSID4048690 Css 3compartmentss Human 95% 0.35 mg/L 0.1019 mg/L 3.43473994111874 -DTXSID4048692 Css 3compartmentss Human 95% 4.302 mg/L 2.898 mg/L 1.48447204968944 -DTXSID4048694 Css 3compartmentss Human 95% 2.503 mg/L 1.597 mg/L 1.56731371321227 -DTXSID4048696 Css 3compartmentss Human 95% 8.1 mg/L 4.5 mg/L 1.8 -DTXSID4048698 Css 3compartmentss Human 95% 0.4261 mg/L 0.005616 mg/L 75.8725071225071 -DTXSID4048721 Css 3compartmentss Human 95% 1.166 mg/L 1.1 mg/L 1.06 -DTXSID4048725 Css 3compartmentss Human 95% 9.61 mg/L 6.026 mg/L 1.59475605708596 -DTXSID4048727 Css 3compartmentss Human 95% 1.903 mg/L 1.05 mg/L 1.81238095238095 -DTXSID4048729 Css 3compartmentss Human 95% 5.669 mg/L 3.628 mg/L 1.56256890848953 -DTXSID4048771 Css 3compartmentss Human 95% 39.17 mg/L 0.1938 mg/L 202.115583075335 -DTXSID4048773 Css 3compartmentss Human 95% 261.8 mg/L 139 mg/L 1.88345323741007 -DTXSID4048775 Css 3compartmentss Human 95% 0.9069 mg/L 0.6523 mg/L 1.39031120650008 -DTXSID4048777 Css 3compartmentss Human 95% 1.567 mg/L 1.043 mg/L 1.50239693192713 -DTXSID4048779 Css 3compartmentss Human 95% 11.27 mg/L 6.821 mg/L 1.65225040316669 -DTXSID4048800 Css 3compartmentss Human 95% 2.263 mg/L 1.226 mg/L 1.84584013050571 -DTXSID4048802 Css 3compartmentss Human 95% 0.6379 mg/L 0.4168 mg/L 1.53047024952015 -DTXSID4048804 Css 3compartmentss Human 95% 26.56 mg/L 1.405 mg/L 18.9039145907473 -DTXSID4048806 Css 3compartmentss Human 95% 0.1993 mg/L 0.1206 mg/L 1.65257048092869 -DTXSID4048808 Css 3compartmentss Human 95% 1.029 mg/L 0.7239 mg/L 1.42146705346042 -DTXSID4048850 Css 3compartmentss Human 95% 2.283 mg/L 1.255 mg/L 1.8191235059761 -DTXSID4048852 Css 3compartmentss Human 95% 6.555 mg/L 3.407 mg/L 1.92398004109187 -DTXSID4048854 Css 3compartmentss Human 95% 20.75 mg/L 14.07 mg/L 1.47476901208244 -DTXSID4048856 Css 3compartmentss Human 95% 0.3289 mg/L 0.1581 mg/L 2.08032890575585 -DTXSID4048858 Css 3compartmentss Human 95% 0.459 mg/L 0.3041 mg/L 1.50937191713252 -DTXSID4048931 Css 3compartmentss Human 95% 1.924 mg/L 0.3187 mg/L 6.03702541575149 -DTXSID4048933 Css 3compartmentss Human 95% 4.859 mg/L 2.174 mg/L 2.23505059797608 -DTXSID4048935 Css 3compartmentss Human 95% 9.238 mg/L 2.355 mg/L 3.92271762208068 -DTXSID4048937 Css 3compartmentss Human 95% 7.293 mg/L 4.23 mg/L 1.7241134751773 -DTXSID4048939 Css 3compartmentss Human 95% 0.5071 mg/L 0.3526 mg/L 1.43817356778219 -DTXSID4048981 Css 3compartmentss Human 95% 9.628 mg/L 5.869 mg/L 1.64048389844948 -DTXSID4048983 Css 3compartmentss Human 95% 0.3243 mg/L 0.1733 mg/L 1.87132140796307 -DTXSID4048985 Css 3compartmentss Human 95% 100.6 mg/L 4.797 mg/L 20.9714404836356 -DTXSID4048987 Css 3compartmentss Human 95% 0.1854 mg/L 0.1179 mg/L 1.57251908396947 -DTXSID4049030 Css 3compartmentss Human 95% 7.782 mg/L 4.65 mg/L 1.67354838709677 -DTXSID4049032 Css 3compartmentss Human 95% 27.45 mg/L 16.64 mg/L 1.64963942307692 -DTXSID4049034 Css 3compartmentss Human 95% 8.424 mg/L 5.207 mg/L 1.61782216247359 -DTXSID4049036 Css 3compartmentss Human 95% 1.307 mg/L 0.6896 mg/L 1.89530162412993 -DTXSID4049038 Css 3compartmentss Human 95% 2.094 mg/L 1.27 mg/L 1.6488188976378 -DTXSID4049080 Css 3compartmentss Human 95% 0.8599 mg/L 0.588 mg/L 1.46241496598639 -DTXSID4049082 Css 3compartmentss Human 95% 13.84 mg/L 7.598 mg/L 1.82153198210055 -DTXSID4049240 Css 3compartmentss Human 95% 0.3122 mg/L 0.2081 mg/L 1.50024026910139 -DTXSID4049242 Css 3compartmentss Human 95% 3.292 mg/L 1.999 mg/L 1.64682341170585 -DTXSID4049244 Css 3compartmentss Human 95% 10.59 mg/L 9.116 mg/L 1.16169372531812 -DTXSID4049248 Css 3compartmentss Human 95% 2.582 mg/L 0.01295 mg/L 199.382239382239 -DTXSID4049290 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID4049298 Css 3compartmentss Human 95% 0.2654 mg/L 0.2149 mg/L 1.23499302000931 -DTXSID4049327 Css 3compartmentss Human 95% 21.83 mg/L 12.53 mg/L 1.74221867517957 -DTXSID4049329 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID4049373 Css 3compartmentss Human 95% 0.2635 mg/L 0.1596 mg/L 1.65100250626566 -DTXSID4049377 Css 3compartmentss Human 95% 5.694 mg/L 3.456 mg/L 1.64756944444444 -DTXSID4049379 Css 3compartmentss Human 95% 11.74 mg/L 6.631 mg/L 1.77047202533555 -DTXSID4049400 Css 3compartmentss Human 95% 13.48 mg/L 8.87 mg/L 1.51972942502818 -DTXSID4049402 Css 3compartmentss Human 95% 6.54 mg/L 4.224 mg/L 1.54829545454545 -DTXSID4049404 Css 3compartmentss Human 95% 6.436 mg/L 4.095 mg/L 1.57167277167277 -DTXSID4049406 Css 3compartmentss Human 95% 0.384 mg/L 0.2343 mg/L 1.63892445582586 -DTXSID4049408 Css 3compartmentss Human 95% 13.52 mg/L 0.3379 mg/L 40.0118378218408 -DTXSID4051536 Css 3compartmentss Human 95% 5.486 mg/L 3.695 mg/L 1.48470906630582 -DTXSID4051580 Css 3compartmentss Human 95% 0.5835 mg/L 0.281 mg/L 2.07651245551601 -DTXSID4051619 Css 3compartmentss Human 95% 6.851 mg/L 5.767 mg/L 1.18796601352523 -DTXSID4052186 Css 3compartmentss Human 95% 3.734 mg/L 4.294 mg/L 0.869585468095016 -DTXSID4052213 Css 3compartmentss Human 95% 3.172 mg/L 1.79 mg/L 1.77206703910615 -DTXSID4052267 Css 3compartmentss Human 95% 0.6282 mg/L 0.4294 mg/L 1.46297158826269 -DTXSID4052269 Css 3compartmentss Human 95% 0.1584 mg/L 0 mg/L Inf -DTXSID4052342 Css 3compartmentss Human 95% 3.101 mg/L 1.867 mg/L 1.66095340117836 -DTXSID4052502 Css 3compartmentss Human 95% 142.6 mg/L 0.8807 mg/L 161.916657204496 -DTXSID4052506 Css 3compartmentss Human 95% 5.547 mg/L 3.804 mg/L 1.45820189274448 -DTXSID4052550 Css 3compartmentss Human 95% 3.869 mg/L 3.273 mg/L 1.18209593644974 -DTXSID4052554 Css 3compartmentss Human 95% 14.65 mg/L 10.2 mg/L 1.43627450980392 -DTXSID4057631 Css 3compartmentss Human 95% 35.85 mg/L 26.29 mg/L 1.36363636363636 -DTXSID4057633 Css 3compartmentss Human 95% 5.663 mg/L 1.527 mg/L 3.70857891290111 -DTXSID4057635 Css 3compartmentss Human 95% 0.4195 mg/L 0.242 mg/L 1.73347107438017 -DTXSID4057637 Css 3compartmentss Human 95% 0.576 mg/L 0.345 mg/L 1.6695652173913 -DTXSID4057639 Css 3compartmentss Human 95% 0.1806 mg/L 0.0972 mg/L 1.85802469135802 -DTXSID4057681 Css 3compartmentss Human 95% 0.9563 mg/L 0.1663 mg/L 5.7504509921828 -DTXSID4057683 Css 3compartmentss Human 95% 2.425 mg/L 1.261 mg/L 1.92307692307692 -DTXSID4057685 Css 3compartmentss Human 95% 48.95 mg/L 28.59 mg/L 1.71213711087793 -DTXSID4057687 Css 3compartmentss Human 95% 5.663 mg/L 3.469 mg/L 1.6324589218795 -DTXSID4057689 Css 3compartmentss Human 95% 7.255 mg/L 0.6265 mg/L 11.5802075019952 -DTXSID4057710 Css 3compartmentss Human 95% 352.8 mg/L 204.1 mg/L 1.72856442920137 -DTXSID4057712 Css 3compartmentss Human 95% 7.092 mg/L 4.466 mg/L 1.58799820868786 -DTXSID4057714 Css 3compartmentss Human 95% 12.52 mg/L 6.319 mg/L 1.98132615920241 -DTXSID4057716 Css 3compartmentss Human 95% 1.724 mg/L 0.9622 mg/L 1.79172729162336 -DTXSID4057718 Css 3compartmentss Human 95% 1.712 mg/L 1.04 mg/L 1.64615384615385 -DTXSID4057760 Css 3compartmentss Human 95% 1.402 mg/L 0.7204 mg/L 1.94614103275958 -DTXSID4057762 Css 3compartmentss Human 95% 19.01 mg/L 10.36 mg/L 1.83494208494209 -DTXSID4057764 Css 3compartmentss Human 95% 1.85 mg/L 1.422 mg/L 1.30098452883263 -DTXSID4057768 Css 3compartmentss Human 95% 1.005 mg/L 0.5687 mg/L 1.76718832424829 -DTXSID4057841 Css 3compartmentss Human 95% 0.9116 mg/L 0.5832 mg/L 1.56310013717421 -DTXSID4057843 Css 3compartmentss Human 95% 1.967 mg/L 1.343 mg/L 1.46463142218913 -DTXSID4057845 Css 3compartmentss Human 95% 4.794 mg/L 3.719 mg/L 1.28905619790266 -DTXSID4057847 Css 3compartmentss Human 95% 40.38 mg/L 22.17 mg/L 1.8213802435724 -DTXSID4057849 Css 3compartmentss Human 95% 103 mg/L 52.08 mg/L 1.97772657450077 -DTXSID4058655 Css 3compartmentss Human 95% 52.71 mg/L 21.82 mg/L 2.41567369385885 -DTXSID40873078 Css 3compartmentss Human 95% 1.015 mg/L 0.7307 mg/L 1.38907896537567 -DTXSID501018140 Css 3compartmentss Human 95% 8.943 mg/L 5.594 mg/L 1.59867715409367 -DTXSID5020021 Css 3compartmentss Human 95% 18.4 mg/L 10.93 mg/L 1.68344007319305 -DTXSID5020027 Css 3compartmentss Human 95% 3.563 mg/L 3.396 mg/L 1.04917550058893 -DTXSID5020071 Css 3compartmentss Human 95% 4.993 mg/L 2.892 mg/L 1.72648686030429 -DTXSID5020079 Css 3compartmentss Human 95% 5.842 mg/L 3.741 mg/L 1.56161454156643 -DTXSID5020106 Css 3compartmentss Human 95% 10.38 mg/L 6.936 mg/L 1.49653979238754 -DTXSID5020108 Css 3compartmentss Human 95% 0.5535 mg/L 0.3838 mg/L 1.4421573736321 -DTXSID5020152 Css 3compartmentss Human 95% 1.98 mg/L 1.455 mg/L 1.36082474226804 -DTXSID5020156 Css 3compartmentss Human 95% 2.257 mg/L 1.644 mg/L 1.37287104622871 -DTXSID5020231 Css 3compartmentss Human 95% 17.39 mg/L 10.48 mg/L 1.65935114503817 -DTXSID5020233 Css 3compartmentss Human 95% 0.09173 mg/L 0 mg/L Inf -DTXSID5020235 Css 3compartmentss Human 95% 12.21 mg/L 7.415 mg/L 1.64666217127444 -DTXSID5020239 Css 3compartmentss Human 95% 16.23 mg/L 3.738 mg/L 4.34189406099518 -DTXSID5020281 Css 3compartmentss Human 95% 0.05458 mg/L 0.04521 mg/L 1.20725503207255 -DTXSID5020283 Css 3compartmentss Human 95% 0.2353 mg/L 0.1565 mg/L 1.50351437699681 -DTXSID5020287 Css 3compartmentss Human 95% 2.526 mg/L 1.663 mg/L 1.51894167167769 -DTXSID5020312 Css 3compartmentss Human 95% 5.589 mg/L 0.000119 mg/L 46966.3865546219 -DTXSID5020360 Css 3compartmentss Human 95% 3.417 mg/L 0.49 mg/L 6.9734693877551 -DTXSID5020366 Css 3compartmentss Human 95% 13.1 mg/L 6.124 mg/L 2.13912475506205 -DTXSID5020368 Css 3compartmentss Human 95% 11.13 mg/L 6.12 mg/L 1.81862745098039 -DTXSID5020441 Css 3compartmentss Human 95% 54.13 mg/L 29.81 mg/L 1.81583361288158 -DTXSID5020443 Css 3compartmentss Human 95% 2.936 mg/L 0.7296 mg/L 4.02412280701754 -DTXSID5020445 Css 3compartmentss Human 95% 2.149 mg/L 0.7012 mg/L 3.06474614945807 -DTXSID5020449 Css 3compartmentss Human 95% 16.56 mg/L 8.944 mg/L 1.8515205724508 -DTXSID5020491 Css 3compartmentss Human 95% 9.18 mg/L 1.018 mg/L 9.01768172888016 -DTXSID5020493 Css 3compartmentss Human 95% 6.077 mg/L 4.109 mg/L 1.4789486493064 -DTXSID5020497 Css 3compartmentss Human 95% 1.466 mg/L 1.1 mg/L 1.33272727272727 -DTXSID5020499 Css 3compartmentss Human 95% 4.912 mg/L 3.291 mg/L 1.49255545426922 -DTXSID5020528 Css 3compartmentss Human 95% 1.124 mg/L 0.6105 mg/L 1.84111384111384 -DTXSID5020570 Css 3compartmentss Human 95% 6.477 mg/L 3.964 mg/L 1.63395560040363 -DTXSID5020572 Css 3compartmentss Human 95% 8.444 mg/L 4.946 mg/L 1.70723817226041 -DTXSID5020576 Css 3compartmentss Human 95% 414 mg/L 449.7 mg/L 0.920613742494997 -DTXSID5020601 Css 3compartmentss Human 95% 4.218 mg/L 1.63 mg/L 2.58773006134969 -DTXSID5020603 Css 3compartmentss Human 95% 2.105 mg/L 1.365 mg/L 1.54212454212454 -DTXSID5020605 Css 3compartmentss Human 95% 2.603 mg/L 2.765 mg/L 0.941410488245931 -DTXSID5020607 Css 3compartmentss Human 95% 2218 mg/L 9739 mg/L 0.227744121573057 -DTXSID5020653 Css 3compartmentss Human 95% 7.221 mg/L 0.04566 mg/L 158.147174770039 -DTXSID5020659 Css 3compartmentss Human 95% 5.933 mg/L 3.798 mg/L 1.56213796735124 -DTXSID5020730 Css 3compartmentss Human 95% 0.6378 mg/L 0.3453 mg/L 1.84708948740226 -DTXSID5020732 Css 3compartmentss Human 95% 53.63 mg/L 27.32 mg/L 1.96303074670571 -DTXSID5020738 Css 3compartmentss Human 95% 28.72 mg/L 16.02 mg/L 1.79275905118602 -DTXSID5020782 Css 3compartmentss Human 95% 604.9 mg/L 308.2 mg/L 1.96268656716418 -DTXSID5020784 Css 3compartmentss Human 95% 486.4 mg/L 347 mg/L 1.40172910662824 -DTXSID5020811 Css 3compartmentss Human 95% 12.34 mg/L 7.519 mg/L 1.64117568825642 -DTXSID5020813 Css 3compartmentss Human 95% 15.64 mg/L 16.11 mg/L 0.97082557417753 -DTXSID5020819 Css 3compartmentss Human 95% 2.436 mg/L 1.665 mg/L 1.46306306306306 -DTXSID5020861 Css 3compartmentss Human 95% 0.5633 mg/L 0.3668 mg/L 1.53571428571429 -DTXSID5020863 Css 3compartmentss Human 95% 5.576 mg/L 2.503 mg/L 2.22772672792649 -DTXSID5020865 Css 3compartmentss Human 95% 1.139 mg/L 0.4137 mg/L 2.75320280396423 -DTXSID5020867 Css 3compartmentss Human 95% 2.756 mg/L 1.895 mg/L 1.45435356200528 -DTXSID5020869 Css 3compartmentss Human 95% 187.4 mg/L 31.86 mg/L 5.88198367859385 -DTXSID5020944 Css 3compartmentss Human 95% 2.721 mg/L 1.869 mg/L 1.45585874799358 -DTXSID5020946 Css 3compartmentss Human 95% 0.9766 mg/L 0.6189 mg/L 1.57796089836807 -DTXSID5020948 Css 3compartmentss Human 95% 13.23 mg/L 8.081 mg/L 1.63717361712659 -DTXSID5021093 Css 3compartmentss Human 95% 0.2614 mg/L 0.19 mg/L 1.37578947368421 -DTXSID5021097 Css 3compartmentss Human 95% 8.196 mg/L 4.985 mg/L 1.64413239719157 -DTXSID5021122 Css 3compartmentss Human 95% 7.339 mg/L 4.941 mg/L 1.48532685691156 -DTXSID5021124 Css 3compartmentss Human 95% 1.038 mg/L 0.7156 mg/L 1.45053102291783 -DTXSID5021126 Css 3compartmentss Human 95% 737.4 mg/L 439.7 mg/L 1.67705253581988 -DTXSID5021170 Css 3compartmentss Human 95% 71.19 mg/L 40.22 mg/L 1.77001491795127 -DTXSID5021174 Css 3compartmentss Human 95% 181.1 mg/L 4.628e-06 mg/L 39131374.2437338 -DTXSID5021201 Css 3compartmentss Human 95% 2.327 mg/L 1.282 mg/L 1.81513260530421 -DTXSID5021209 Css 3compartmentss Human 95% 2.767 mg/L 1.654 mg/L 1.67291414752116 -DTXSID5021251 Css 3compartmentss Human 95% 3.382 mg/L 2.014 mg/L 1.67924528301887 -DTXSID5021253 Css 3compartmentss Human 95% 10.61 mg/L 6.461 mg/L 1.64216065624516 -DTXSID5021255 Css 3compartmentss Human 95% 4.404 mg/L 2.235 mg/L 1.97046979865772 -DTXSID5021330 Css 3compartmentss Human 95% 3.217 mg/L 2.299 mg/L 1.39930404523706 -DTXSID5021332 Css 3compartmentss Human 95% 20.92 mg/L 11.01 mg/L 1.90009082652134 -DTXSID5021334 Css 3compartmentss Human 95% 7.29 mg/L 5.033 mg/L 1.44844029405921 -DTXSID5021336 Css 3compartmentss Human 95% 3.212 mg/L 2.209 mg/L 1.45405160706202 -DTXSID5021338 Css 3compartmentss Human 95% 2.407 mg/L 1.484 mg/L 1.62196765498652 -DTXSID5021386 Css 3compartmentss Human 95% 18.28 mg/L 7.225 mg/L 2.53010380622837 -DTXSID5021388 Css 3compartmentss Human 95% 194.8 mg/L 113.3 mg/L 1.71932921447485 -DTXSID5021411 Css 3compartmentss Human 95% 1.323 mg/L 0.9332 mg/L 1.4177025289327 -DTXSID5021415 Css 3compartmentss Human 95% 1.476 mg/L 0.994 mg/L 1.48490945674044 -DTXSID5021419 Css 3compartmentss Human 95% 4.772 mg/L 1.948 mg/L 2.44969199178645 -DTXSID5021461 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID5021463 Css 3compartmentss Human 95% 2.559 mg/L 1.591 mg/L 1.60842237586424 -DTXSID5021544 Css 3compartmentss Human 95% 1.107 mg/L 0.6866 mg/L 1.61229245557821 -DTXSID5021546 Css 3compartmentss Human 95% 7.41 mg/L 4.614 mg/L 1.60598179453836 -DTXSID5021590 Css 3compartmentss Human 95% 37.9 mg/L 22.39 mg/L 1.69271996426976 -DTXSID5021598 Css 3compartmentss Human 95% 3.674 mg/L 2.172 mg/L 1.69152854511971 -DTXSID5021621 Css 3compartmentss Human 95% 7.979 mg/L 5.007 mg/L 1.59356900339525 -DTXSID5021627 Css 3compartmentss Human 95% 9.784 mg/L 6.255 mg/L 1.56418864908074 -DTXSID5021671 Css 3compartmentss Human 95% 8.178 mg/L 5.345 mg/L 1.53002806361085 -DTXSID5021679 Css 3compartmentss Human 95% 8.196 mg/L 5.87 mg/L 1.39625212947189 -DTXSID5021708 Css 3compartmentss Human 95% 24.16 mg/L 14.11 mg/L 1.71226080793763 -DTXSID5021754 Css 3compartmentss Human 95% 5.687 mg/L 1.848 mg/L 3.07738095238095 -DTXSID5021756 Css 3compartmentss Human 95% 5.503 mg/L 3.717 mg/L 1.4804950228679 -DTXSID5021758 Css 3compartmentss Human 95% 0.2979 mg/L 0.1302 mg/L 2.28801843317972 -DTXSID5021831 Css 3compartmentss Human 95% 3.749 mg/L 2.082 mg/L 1.80067243035543 -DTXSID5021835 Css 3compartmentss Human 95% 0.3667 mg/L 0.2405 mg/L 1.52474012474012 -DTXSID5021837 Css 3compartmentss Human 95% 4.33 mg/L 3.205 mg/L 1.35101404056162 -DTXSID5021839 Css 3compartmentss Human 95% 1.547 mg/L 1.141 mg/L 1.3558282208589 -DTXSID5021881 Css 3compartmentss Human 95% 5.503 mg/L 3.684 mg/L 1.49375678610206 -DTXSID5021883 Css 3compartmentss Human 95% 6.7 mg/L 4.293 mg/L 1.56068017703238 -DTXSID5021885 Css 3compartmentss Human 95% 5.286 mg/L 2.867 mg/L 1.84373910010464 -DTXSID5021910 Css 3compartmentss Human 95% 2.86 mg/L 1.691 mg/L 1.69130691898285 -DTXSID5021962 Css 3compartmentss Human 95% 1.239 mg/L 0.7428 mg/L 1.66801292407108 -DTXSID5021968 Css 3compartmentss Human 95% 0.6321 mg/L 0.4046 mg/L 1.56228373702422 -DTXSID5022061 Css 3compartmentss Human 95% 2.446 mg/L 1.337 mg/L 1.82946896035901 -DTXSID5022198 Css 3compartmentss Human 95% 1.334 mg/L 0.8537 mg/L 1.56260981609465 -DTXSID5022227 Css 3compartmentss Human 95% 2.229 mg/L 1.582 mg/L 1.40897597977244 -DTXSID5022271 Css 3compartmentss Human 95% 2.147 mg/L 1.378 mg/L 1.55805515239477 -DTXSID5022279 Css 3compartmentss Human 95% 6.97 mg/L 4.929 mg/L 1.41407993507811 -DTXSID5022306 Css 3compartmentss Human 95% 0.1246 mg/L 0.09618 mg/L 1.29548762736536 -DTXSID5022308 Css 3compartmentss Human 95% 12.25 mg/L 5.594 mg/L 2.18984626385413 -DTXSID5022437 Css 3compartmentss Human 95% 3.01 mg/L 1.28 mg/L 2.3515625 -DTXSID5022439 Css 3compartmentss Human 95% 86.13 mg/L 48.76 mg/L 1.76640689089418 -DTXSID5022481 Css 3compartmentss Human 95% 0.008282 mg/L 0 mg/L Inf -DTXSID5022485 Css 3compartmentss Human 95% 510.3 mg/L 755.6 mg/L 0.675357331921652 -DTXSID5022489 Css 3compartmentss Human 95% 31.77 mg/L 18.03 mg/L 1.76206322795341 -DTXSID5022510 Css 3compartmentss Human 95% 2.717 mg/L 2.718 mg/L 0.999632082413539 -DTXSID5022560 Css 3compartmentss Human 95% 7.758 mg/L 4.767 mg/L 1.6274386406545 -DTXSID5022562 Css 3compartmentss Human 95% 2.395 mg/L 1.423 mg/L 1.68306394940267 -DTXSID5022641 Css 3compartmentss Human 95% 2.728 mg/L 1.696 mg/L 1.60849056603774 -DTXSID5022643 Css 3compartmentss Human 95% 7.039 mg/L 4.57 mg/L 1.54026258205689 -DTXSID5022647 Css 3compartmentss Human 95% 1.548 mg/L 0.8036 mg/L 1.92633150821304 -DTXSID5022649 Css 3compartmentss Human 95% 3.029 mg/L 1.528 mg/L 1.98232984293194 -DTXSID5022699 Css 3compartmentss Human 95% 5.711 mg/L 2.909 mg/L 1.96321760055002 -DTXSID5022722 Css 3compartmentss Human 95% 1.509 mg/L 7.541e-05 mg/L 20010.6086725898 -DTXSID5022724 Css 3compartmentss Human 95% 10.71 mg/L 4.953 mg/L 2.16232586311326 -DTXSID5022774 Css 3compartmentss Human 95% 9.089 mg/L 5.723 mg/L 1.58815306657348 -DTXSID5022801 Css 3compartmentss Human 95% 31.15 mg/L 15.26 mg/L 2.04128440366972 -DTXSID5022803 Css 3compartmentss Human 95% 0.1749 mg/L 0.096 mg/L 1.821875 -DTXSID5022851 Css 3compartmentss Human 95% 11.04 mg/L 4.794 mg/L 2.30287859824781 -DTXSID5022855 Css 3compartmentss Human 95% 5.755 mg/L 2.166 mg/L 2.65697137580794 -DTXSID5022857 Css 3compartmentss Human 95% 0.8026 mg/L 0.4929 mg/L 1.62832217488334 -DTXSID5022932 Css 3compartmentss Human 95% 882.5 mg/L 454.1 mg/L 1.94340453644572 -DTXSID5022934 Css 3compartmentss Human 95% 6.856 mg/L 4.914 mg/L 1.3951973951974 -DTXSID5022938 Css 3compartmentss Human 95% 0.0856 mg/L 0 mg/L Inf -DTXSID5022980 Css 3compartmentss Human 95% 0.8034 mg/L 0.09207 mg/L 8.72596937113066 -DTXSID5022982 Css 3compartmentss Human 95% 11.38 mg/L 6.946 mg/L 1.638353008926 -DTXSID5022984 Css 3compartmentss Human 95% 0.7973 mg/L 0.4755 mg/L 1.67676130389064 -DTXSID5022986 Css 3compartmentss Human 95% 1.236 mg/L 0.8793 mg/L 1.40566359604231 -DTXSID5023031 Css 3compartmentss Human 95% 1.724 mg/L 1.074 mg/L 1.60521415270019 -DTXSID5023033 Css 3compartmentss Human 95% 1.31 mg/L 1.133 mg/L 1.15622241835834 -DTXSID5023035 Css 3compartmentss Human 95% 1.533 mg/L 0.8334 mg/L 1.8394528437725 -DTXSID5023039 Css 3compartmentss Human 95% 2.88 mg/L 1.94 mg/L 1.48453608247423 -DTXSID5023081 Css 3compartmentss Human 95% 5.667 mg/L 3.628 mg/L 1.56201764057332 -DTXSID5023085 Css 3compartmentss Human 95% 39.93 mg/L 23.38 mg/L 1.70786997433704 -DTXSID5023089 Css 3compartmentss Human 95% 935.5 mg/L 2223 mg/L 0.420827710301394 -DTXSID5023110 Css 3compartmentss Human 95% 0.7256 mg/L 0.119 mg/L 6.09747899159664 -DTXSID5023114 Css 3compartmentss Human 95% 0.01194 mg/L 0.007209 mg/L 1.65626300457761 -DTXSID5023166 Css 3compartmentss Human 95% 41.52 mg/L 24.54 mg/L 1.6919315403423 -DTXSID5023243 Css 3compartmentss Human 95% 27.7 mg/L 9.059 mg/L 3.05773264157192 -DTXSID5023247 Css 3compartmentss Human 95% 12.35 mg/L 7.924 mg/L 1.55855628470469 -DTXSID5023293 Css 3compartmentss Human 95% 0.08952 mg/L 0.06372 mg/L 1.40489642184557 -DTXSID5023295 Css 3compartmentss Human 95% 5.798 mg/L 3.841 mg/L 1.50950273366311 -DTXSID5023299 Css 3compartmentss Human 95% 1.268 mg/L 0.8777 mg/L 1.44468497208613 -DTXSID5023320 Css 3compartmentss Human 95% 5.649 mg/L 3.165 mg/L 1.78483412322275 -DTXSID5023322 Css 3compartmentss Human 95% 8.976 mg/L 1.099 mg/L 8.16742493175614 -DTXSID5023324 Css 3compartmentss Human 95% 82.15 mg/L 44.81 mg/L 1.83329613925463 -DTXSID5023370 Css 3compartmentss Human 95% 1.605 mg/L 0.5914 mg/L 2.71389922218465 -DTXSID5023372 Css 3compartmentss Human 95% 4.946 mg/L 3.361 mg/L 1.47158583754835 -DTXSID5023376 Css 3compartmentss Human 95% 0.1762 mg/L 0.1099 mg/L 1.60327570518653 -DTXSID5023378 Css 3compartmentss Human 95% 1.8 mg/L 1.265 mg/L 1.42292490118577 -DTXSID5023453 Css 3compartmentss Human 95% 218.3 mg/L 124.1 mg/L 1.75906526994359 -DTXSID5023532 Css 3compartmentss Human 95% 0.5953 mg/L 0.3131 mg/L 1.90130948578729 -DTXSID5023536 Css 3compartmentss Human 95% 1.802 mg/L 1.043 mg/L 1.72770853307766 -DTXSID5023582 Css 3compartmentss Human 95% 3.221 mg/L 1.388 mg/L 2.32060518731988 -DTXSID5023584 Css 3compartmentss Human 95% 0.01495 mg/L 0 mg/L Inf -DTXSID5023586 Css 3compartmentss Human 95% 0.9832 mg/L 0.05098 mg/L 19.2859945076501 -DTXSID5023588 Css 3compartmentss Human 95% 5.588 mg/L 3.628 mg/L 1.54024255788313 -DTXSID5023611 Css 3compartmentss Human 95% 5.191 mg/L 2.874 mg/L 1.80619345859429 -DTXSID5023613 Css 3compartmentss Human 95% 5.317 mg/L 2.969 mg/L 1.79083866621758 -DTXSID5023615 Css 3compartmentss Human 95% 9.836 mg/L 5.339 mg/L 1.84229256415059 -DTXSID5023661 Css 3compartmentss Human 95% 5.332 mg/L 3.431 mg/L 1.55406587000874 -DTXSID5023665 Css 3compartmentss Human 95% 242.8 mg/L 138 mg/L 1.75942028985507 -DTXSID5023667 Css 3compartmentss Human 95% 1.848 mg/L 1.147 mg/L 1.61115954664342 -DTXSID5023740 Css 3compartmentss Human 95% 997.8 mg/L 1444 mg/L 0.690997229916897 -DTXSID5023742 Css 3compartmentss Human 95% 291.7 mg/L 168.3 mg/L 1.73321449792038 -DTXSID5023744 Css 3compartmentss Human 95% 6.446 mg/L 3.361 mg/L 1.91788158286224 -DTXSID5023746 Css 3compartmentss Human 95% 13.91 mg/L 1.679 mg/L 8.28469326980345 -DTXSID5023748 Css 3compartmentss Human 95% 1.624 mg/L 1.206 mg/L 1.34660033167496 -DTXSID5023792 Css 3compartmentss Human 95% 0.7784 mg/L 0.5264 mg/L 1.47872340425532 -DTXSID5023794 Css 3compartmentss Human 95% 17.82 mg/L 10.88 mg/L 1.63786764705882 -DTXSID5023796 Css 3compartmentss Human 95% 1.207 mg/L 0.6905 mg/L 1.74800868935554 -DTXSID5023825 Css 3compartmentss Human 95% 7.973 mg/L 5.686 mg/L 1.40221596904678 -DTXSID5023871 Css 3compartmentss Human 95% 31.92 mg/L 1.08 mg/L 29.5555555555556 -DTXSID5023875 Css 3compartmentss Human 95% 8.572 mg/L 5.31 mg/L 1.61431261770245 -DTXSID5023877 Css 3compartmentss Human 95% 7.631 mg/L 4.973 mg/L 1.53448622561834 -DTXSID5023902 Css 3compartmentss Human 95% 29.28 mg/L 0.07776 mg/L 376.543209876543 -DTXSID5023950 Css 3compartmentss Human 95% 16.02 mg/L 0.7152 mg/L 22.3993288590604 -DTXSID5023954 Css 3compartmentss Human 95% 2.577 mg/L 0.0006066 mg/L 4248.26904055391 -DTXSID5024001 Css 3compartmentss Human 95% 8.362 mg/L 5.371 mg/L 1.55687953826103 -DTXSID5024051 Css 3compartmentss Human 95% 4.772 mg/L 2.366 mg/L 2.01690617075232 -DTXSID5024055 Css 3compartmentss Human 95% 5.376 mg/L 3.368 mg/L 1.59619952494062 -DTXSID5024057 Css 3compartmentss Human 95% 6.893 mg/L 4.458 mg/L 1.5462090623598 -DTXSID5024059 Css 3compartmentss Human 95% 31.39 mg/L 25.32 mg/L 1.23973143759874 -DTXSID5024134 Css 3compartmentss Human 95% 114.7 mg/L 135.5 mg/L 0.846494464944649 -DTXSID5024182 Css 3compartmentss Human 95% 5.689 mg/L 3.852 mg/L 1.47689511941848 -DTXSID5024211 Css 3compartmentss Human 95% 6.498 mg/L 3.671 mg/L 1.77008989376192 -DTXSID5024261 Css 3compartmentss Human 95% 4.839 mg/L 2.555 mg/L 1.89393346379648 -DTXSID5024263 Css 3compartmentss Human 95% 7.543 mg/L 4.729 mg/L 1.59505180799323 -DTXSID5024392 Css 3compartmentss Human 95% 11.62 mg/L 6.925 mg/L 1.67797833935018 -DTXSID5024394 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID5024471 Css 3compartmentss Human 95% 0.3708 mg/L 0.2478 mg/L 1.49636803874092 -DTXSID5024473 Css 3compartmentss Human 95% 0.4695 mg/L 0.3015 mg/L 1.55721393034826 -DTXSID5024479 Css 3compartmentss Human 95% 12.83 mg/L 7.483 mg/L 1.71455298677001 -DTXSID5024500 Css 3compartmentss Human 95% 9.214 mg/L 5.611 mg/L 1.64213152735698 -DTXSID5024504 Css 3compartmentss Human 95% 7.072 mg/L 4.149 mg/L 1.70450711014702 -DTXSID5024506 Css 3compartmentss Human 95% 8.154 mg/L 5.082 mg/L 1.60448642266824 -DTXSID5024508 Css 3compartmentss Human 95% 0.7091 mg/L 0.4763 mg/L 1.4887675834558 -DTXSID5024554 Css 3compartmentss Human 95% 0.385 mg/L 0.2186 mg/L 1.7612076852699 -DTXSID5024681 Css 3compartmentss Human 95% 0.5503 mg/L 0.383 mg/L 1.43681462140992 -DTXSID5024683 Css 3compartmentss Human 95% 1.446 mg/L 0.609 mg/L 2.3743842364532 -DTXSID5024687 Css 3compartmentss Human 95% 5.291 mg/L 5.374 mg/L 0.984555266096018 -DTXSID5024710 Css 3compartmentss Human 95% 5.592 mg/L 3.673 mg/L 1.52246120337599 -DTXSID5024764 Css 3compartmentss Human 95% 1.168 mg/L 0.9109 mg/L 1.2822483258316 -DTXSID5024845 Css 3compartmentss Human 95% 3.8 mg/L 2.356 mg/L 1.61290322580645 -DTXSID5024891 Css 3compartmentss Human 95% 0.1666 mg/L 0.123 mg/L 1.35447154471545 -DTXSID5024922 Css 3compartmentss Human 95% 0.4836 mg/L 0.3477 mg/L 1.39085418464193 -DTXSID5024926 Css 3compartmentss Human 95% 12.92 mg/L 7.718 mg/L 1.67400881057269 -DTXSID5024976 Css 3compartmentss Human 95% 113.3 mg/L 63.4 mg/L 1.78706624605678 -DTXSID5024978 Css 3compartmentss Human 95% 104 mg/L 57.18 mg/L 1.81881776845051 -DTXSID5025021 Css 3compartmentss Human 95% 7.376 mg/L 0.007323 mg/L 1007.23747098184 -DTXSID5025071 Css 3compartmentss Human 95% 23.82 mg/L 21.32 mg/L 1.1172607879925 -DTXSID5025100 Css 3compartmentss Human 95% 2.636 mg/L 1.755 mg/L 1.5019943019943 -DTXSID5025102 Css 3compartmentss Human 95% 2.471 mg/L 1.662 mg/L 1.48676293622142 -DTXSID5025150 Css 3compartmentss Human 95% 8.248 mg/L 5.123 mg/L 1.60999414405622 -DTXSID5025152 Css 3compartmentss Human 95% 0.01975 mg/L 0.01351 mg/L 1.46188008882309 -DTXSID5025156 Css 3compartmentss Human 95% 5.589 mg/L 3.061 mg/L 1.82587389741914 -DTXSID5025231 Css 3compartmentss Human 95% 58.39 mg/L 30.4 mg/L 1.92072368421053 -DTXSID5025237 Css 3compartmentss Human 95% 5.067 mg/L 3.749 mg/L 1.35156041611096 -DTXSID5025310 Css 3compartmentss Human 95% 2.61 mg/L 1.592 mg/L 1.6394472361809 -DTXSID5025312 Css 3compartmentss Human 95% 5.202 mg/L 3.629 mg/L 1.43345274180215 -DTXSID5025364 Css 3compartmentss Human 95% 8.023 mg/L 5.221 mg/L 1.53667879716529 -DTXSID5025449 Css 3compartmentss Human 95% 4.907 mg/L 5.594 mg/L 0.877189846263854 -DTXSID5025491 Css 3compartmentss Human 95% 84.4 mg/L 167.7 mg/L 0.503279666070364 -DTXSID5025570 Css 3compartmentss Human 95% 0.3329 mg/L 0.2176 mg/L 1.52987132352941 -DTXSID5025572 Css 3compartmentss Human 95% 0.1007 mg/L 0.07025 mg/L 1.43345195729537 -DTXSID5025574 Css 3compartmentss Human 95% 0.9992 mg/L 0.6615 mg/L 1.51050642479214 -DTXSID5025603 Css 3compartmentss Human 95% 3.585 mg/L 2.352 mg/L 1.52423469387755 -DTXSID5025653 Css 3compartmentss Human 95% 1.526 mg/L 1.193 mg/L 1.279128248114 -DTXSID5025659 Css 3compartmentss Human 95% 0.04555 mg/L 0.02468 mg/L 1.84562398703404 -DTXSID5025730 Css 3compartmentss Human 95% 21.43 mg/L 1.483 mg/L 14.4504383007417 -DTXSID5025732 Css 3compartmentss Human 95% 4.964 mg/L 3.279 mg/L 1.51387618176273 -DTXSID5025738 Css 3compartmentss Human 95% 9.083 mg/L 5.416 mg/L 1.67706794682422 -DTXSID5025811 Css 3compartmentss Human 95% 136.9 mg/L 9.666e-06 mg/L 14163045.7272915 -DTXSID5025815 Css 3compartmentss Human 95% 2.398 mg/L 0.7848 mg/L 3.05555555555556 -DTXSID5025861 Css 3compartmentss Human 95% 7.025 mg/L 3.415 mg/L 2.05710102489019 -DTXSID5025863 Css 3compartmentss Human 95% 0.3186 mg/L 0.1881 mg/L 1.69377990430622 -DTXSID5025948 Css 3compartmentss Human 95% 7.815 mg/L 4.885 mg/L 1.59979529170931 -DTXSID5025998 Css 3compartmentss Human 95% 14.5 mg/L 0.000147 mg/L 98639.4557823129 -DTXSID5026120 Css 3compartmentss Human 95% 1.083 mg/L 0.5562 mg/L 1.94714131607335 -DTXSID5026124 Css 3compartmentss Human 95% 0.2698 mg/L 0.1613 mg/L 1.67265964042157 -DTXSID5026178 Css 3compartmentss Human 95% 8.329 mg/L 5.107 mg/L 1.63089876639906 -DTXSID5026203 Css 3compartmentss Human 95% 126.7 mg/L 178.1 mg/L 0.711398090960135 -DTXSID5026205 Css 3compartmentss Human 95% 138.4 mg/L 202.8 mg/L 0.682445759368836 -DTXSID5026207 Css 3compartmentss Human 95% 50 mg/L 16.97 mg/L 2.94637595757219 -DTXSID5026209 Css 3compartmentss Human 95% 208 mg/L 90.35 mg/L 2.3021582733813 -DTXSID5026251 Css 3compartmentss Human 95% 40.08 mg/L 0.08405 mg/L 476.859012492564 -DTXSID5026259 Css 3compartmentss Human 95% 0.1305 mg/L 0.07226 mg/L 1.80597841129255 -DTXSID5026544 Css 3compartmentss Human 95% 11.39 mg/L 7.383 mg/L 1.54273330624407 -DTXSID5026548 Css 3compartmentss Human 95% 0.1675 mg/L 0.1106 mg/L 1.51446654611212 -DTXSID5026623 Css 3compartmentss Human 95% 18.82 mg/L 23.68 mg/L 0.794763513513513 -DTXSID5026625 Css 3compartmentss Human 95% 4.558 mg/L 4.85 mg/L 0.93979381443299 -DTXSID5026702 Css 3compartmentss Human 95% 0.03226 mg/L 0.01794 mg/L 1.79821627647715 -DTXSID5026881 Css 3compartmentss Human 95% 1876 mg/L 9739 mg/L 0.192627579833658 -DTXSID5026912 Css 3compartmentss Human 95% 5.03 mg/L 3.498 mg/L 1.4379645511721 -DTXSID5026918 Css 3compartmentss Human 95% 12.11 mg/L 0.2583 mg/L 46.8834688346884 -DTXSID5027019 Css 3compartmentss Human 95% 716.9 mg/L 0.02795 mg/L 25649.373881932 -DTXSID5027063 Css 3compartmentss Human 95% 11.38 mg/L 6.988 mg/L 1.62850601030338 -DTXSID5027069 Css 3compartmentss Human 95% 5.639 mg/L 4.367 mg/L 1.29127547515457 -DTXSID5027198 Css 3compartmentss Human 95% 0.0548 mg/L 0.04013 mg/L 1.36556192374782 -DTXSID5027279 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID5027300 Css 3compartmentss Human 95% 1.115 mg/L 0.5072 mg/L 2.19834384858044 -DTXSID5027302 Css 3compartmentss Human 95% 246.3 mg/L 232.4 mg/L 1.05981067125645 -DTXSID5027304 Css 3compartmentss Human 95% 215.1 mg/L 334.4 mg/L 0.643241626794258 -DTXSID5027356 Css 3compartmentss Human 95% 0.273 mg/L 0.1573 mg/L 1.73553719008264 -DTXSID5027358 Css 3compartmentss Human 95% 9.237 mg/L 5.541 mg/L 1.66702761234434 -DTXSID5027433 Css 3compartmentss Human 95% 0.01662 mg/L 0.01353 mg/L 1.22838137472284 -DTXSID5027487 Css 3compartmentss Human 95% 0.3625 mg/L 0.2205 mg/L 1.64399092970522 -DTXSID5027489 Css 3compartmentss Human 95% 0.119 mg/L 0.07138 mg/L 1.6671336508826 -DTXSID5027512 Css 3compartmentss Human 95% 1.003 mg/L 0.7075 mg/L 1.41766784452297 -DTXSID5027518 Css 3compartmentss Human 95% 1.902 mg/L 0.0004121 mg/L 4615.38461538462 -DTXSID5027641 Css 3compartmentss Human 95% 0.535 mg/L 0.4377 mg/L 1.2222983778844 -DTXSID5027728 Css 3compartmentss Human 95% 0.001147 mg/L 0 mg/L Inf -DTXSID5027770 Css 3compartmentss Human 95% 1.066 mg/L 0.6993 mg/L 1.52438152438152 -DTXSID5027772 Css 3compartmentss Human 95% 0.5559 mg/L 0.4157 mg/L 1.3372624488814 -DTXSID5027774 Css 3compartmentss Human 95% 5.506 mg/L 2.503 mg/L 2.19976028765481 -DTXSID5027803 Css 3compartmentss Human 95% 0.1871 mg/L 0.1423 mg/L 1.31482782853127 -DTXSID5027805 Css 3compartmentss Human 95% 0.7726 mg/L 0.447 mg/L 1.72841163310962 -DTXSID5027851 Css 3compartmentss Human 95% 166.6 mg/L 111 mg/L 1.5009009009009 -DTXSID5027857 Css 3compartmentss Human 95% 0.1557 mg/L 0.1333 mg/L 1.16804201050263 -DTXSID5027932 Css 3compartmentss Human 95% 32.01 mg/L 11.79 mg/L 2.71501272264631 -DTXSID5027936 Css 3compartmentss Human 95% 5.825 mg/L 3.853 mg/L 1.51180898001557 -DTXSID5027982 Css 3compartmentss Human 95% 0.05255 mg/L 0 mg/L Inf -DTXSID5028033 Css 3compartmentss Human 95% 3.745e-05 mg/L 0 mg/L Inf -DTXSID5028665 Css 3compartmentss Human 95% 0.03227 mg/L 0 mg/L Inf -DTXSID5029055 Css 3compartmentss Human 95% 3.403 mg/L 0.03697 mg/L 92.0476061671626 -DTXSID5029059 Css 3compartmentss Human 95% 11220 mg/L 9739 mg/L 1.15206900092412 -DTXSID5029136 Css 3compartmentss Human 95% 43.69 mg/L 24.9 mg/L 1.75461847389558 -DTXSID5029182 Css 3compartmentss Human 95% 7.742 mg/L 4.714 mg/L 1.64234196011879 -DTXSID5029184 Css 3compartmentss Human 95% 8.516 mg/L 5.274 mg/L 1.61471368979901 -DTXSID5029186 Css 3compartmentss Human 95% 4.225 mg/L 2.543 mg/L 1.66142351553283 -DTXSID5029211 Css 3compartmentss Human 95% 279.8 mg/L 162.9 mg/L 1.71761817065684 -DTXSID5029217 Css 3compartmentss Human 95% 5.6 mg/L 3.862 mg/L 1.45002589331952 -DTXSID5029263 Css 3compartmentss Human 95% 5.576 mg/L 2.14 mg/L 2.60560747663551 -DTXSID5029265 Css 3compartmentss Human 95% 0.6386 mg/L 0.3826 mg/L 1.66910611604809 -DTXSID5029267 Css 3compartmentss Human 95% 3.063 mg/L 1.587 mg/L 1.93005671077505 -DTXSID5029683 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID5029710 Css 3compartmentss Human 95% 8.083 mg/L 5.816 mg/L 1.38978679504814 -DTXSID5029762 Css 3compartmentss Human 95% 367.5 mg/L 198.9 mg/L 1.84766214177979 -DTXSID5030030 Css 3compartmentss Human 95% 352.7 mg/L 204.8 mg/L 1.72216796875 -DTXSID5031131 Css 3compartmentss Human 95% 1.725 mg/L 0.05406 mg/L 31.9089900110988 -DTXSID5031133 Css 3compartmentss Human 95% 0.1115 mg/L 0.07904 mg/L 1.41067813765182 -DTXSID5031210 Css 3compartmentss Human 95% 1.692 mg/L 1.205 mg/L 1.40414937759336 -DTXSID5031428 Css 3compartmentss Human 95% 0.2247 mg/L 0.1405 mg/L 1.59928825622776 -DTXSID5032020 Css 3compartmentss Human 95% 5.609 mg/L 3.223 mg/L 1.74030406453615 -DTXSID5032315 Css 3compartmentss Human 95% 90.15 mg/L 41.95 mg/L 2.14898688915375 -DTXSID5032361 Css 3compartmentss Human 95% 2.834 mg/L 3.505 mg/L 0.808559201141227 -DTXSID5032365 Css 3compartmentss Human 95% 77.69 mg/L 68.36 mg/L 1.13648332358104 -DTXSID5032442 Css 3compartmentss Human 95% 1.689 mg/L 1.069 mg/L 1.5799812909261 -DTXSID5032498 Css 3compartmentss Human 95% 16.43 mg/L 1.989 mg/L 8.26043237807944 -DTXSID5032523 Css 3compartmentss Human 95% 0.3145 mg/L 0.1859 mg/L 1.69176976869285 -DTXSID5032525 Css 3compartmentss Human 95% 0.6742 mg/L 0.592 mg/L 1.13885135135135 -DTXSID5032573 Css 3compartmentss Human 95% 5.767 mg/L 0.0002362 mg/L 24415.749364945 -DTXSID5032577 Css 3compartmentss Human 95% 12.76 mg/L 0.0002501 mg/L 51019.5921631347 -DTXSID5032579 Css 3compartmentss Human 95% 0.2945 mg/L 0.1611 mg/L 1.82805710738672 -DTXSID5032600 Css 3compartmentss Human 95% 5.726 mg/L 3.262 mg/L 1.75536480686695 -DTXSID5032654 Css 3compartmentss Human 95% 0.07849 mg/L 0.04121 mg/L 1.90463479737928 -DTXSID5033096 Css 3compartmentss Human 95% 4.872 mg/L 2.833 mg/L 1.71973173314508 -DTXSID5033098 Css 3compartmentss Human 95% 7.727 mg/L 4.749 mg/L 1.62707938513371 -DTXSID5033179 Css 3compartmentss Human 95% 6.233 mg/L 3.957 mg/L 1.57518321961082 -DTXSID5033389 Css 3compartmentss Human 95% 104.4 mg/L 65.97 mg/L 1.58253751705321 -DTXSID5033468 Css 3compartmentss Human 95% 3.294 mg/L 0.01527 mg/L 215.717092337917 -DTXSID5033595 Css 3compartmentss Human 95% 0.9613 mg/L 0.5037 mg/L 1.90847726821521 -DTXSID5033674 Css 3compartmentss Human 95% 0.04113 mg/L 0.02923 mg/L 1.40711597673623 -DTXSID5033757 Css 3compartmentss Human 95% 86.32 mg/L 43.23 mg/L 1.99676150821189 -DTXSID5033836 Css 3compartmentss Human 95% 3.705 mg/L 0.004922 mg/L 752.742787484762 -DTXSID5034270 Css 3compartmentss Human 95% 10.96 mg/L 9.097 mg/L 1.20479278883148 -DTXSID5034303 Css 3compartmentss Human 95% 721.7 mg/L 1054 mg/L 0.68472485768501 -DTXSID5034355 Css 3compartmentss Human 95% 75.35 mg/L 2.941 mg/L 25.6205372322339 -DTXSID5034357 Css 3compartmentss Human 95% 10.94 mg/L 0.1999 mg/L 54.7273636818409 -DTXSID5034698 Css 3compartmentss Human 95% 89.5 mg/L 0.07024 mg/L 1274.20273348519 -DTXSID5034723 Css 3compartmentss Human 95% 19.49 mg/L 11.26 mg/L 1.73090586145648 -DTXSID5034729 Css 3compartmentss Human 95% 1.624 mg/L 0.8693 mg/L 1.8681697917865 -DTXSID5034773 Css 3compartmentss Human 95% 182.2 mg/L 1.892 mg/L 96.3002114164905 -DTXSID5034981 Css 3compartmentss Human 95% 0.584 mg/L 8e-09 mg/L 7.3e+07 -DTXSID5035163 Css 3compartmentss Human 95% 0.01015 mg/L 0.006719 mg/L 1.51064146450365 -DTXSID5035589 Css 3compartmentss Human 95% 0.625 mg/L 0.005807 mg/L 107.628723953849 -DTXSID5035616 Css 3compartmentss Human 95% 12.55 mg/L 7.965 mg/L 1.57564344005022 -DTXSID5035957 Css 3compartmentss Human 95% 29.48 mg/L 0.4634 mg/L 63.6167457919724 -DTXSID5036684 Css 3compartmentss Human 95% 4.407 mg/L 2.645 mg/L 1.66616257088847 -DTXSID5037028 Css 3compartmentss Human 95% 0.1503 mg/L 0.002454 mg/L 61.2469437652812 -DTXSID5037072 Css 3compartmentss Human 95% 11.19 mg/L 7.015 mg/L 1.59515324305061 -DTXSID5037494 Css 3compartmentss Human 95% 3.279 mg/L 2.317 mg/L 1.41519205869659 -DTXSID5037498 Css 3compartmentss Human 95% 4.065 mg/L 1.551 mg/L 2.62088974854932 -DTXSID5037523 Css 3compartmentss Human 95% 0.3176 mg/L 0.2383 mg/L 1.33277381451951 -DTXSID5037527 Css 3compartmentss Human 95% 0.6067 mg/L 0.3141 mg/L 1.93155046163642 -DTXSID5037577 Css 3compartmentss Human 95% 0.6596 mg/L 0.0007132 mg/L 924.845765563657 -DTXSID5037579 Css 3compartmentss Human 95% 1.233 mg/L 0.6364 mg/L 1.93746071653048 -DTXSID5037731 Css 3compartmentss Human 95% 445.8 mg/L 149.2 mg/L 2.98793565683646 -DTXSID5037739 Css 3compartmentss Human 95% 0.8435 mg/L 0.4194 mg/L 2.01120648545541 -DTXSID5038888 Css 3compartmentss Human 95% 126.7 mg/L 0.1402 mg/L 903.708987161198 -DTXSID5038919 Css 3compartmentss Human 95% 2.124 mg/L 1.369 mg/L 1.55149744338934 -DTXSID5039721 Css 3compartmentss Human 95% 65.36 mg/L 54.29 mg/L 1.20390495487198 -DTXSID5040413 Css 3compartmentss Human 95% 12.52 mg/L 7.88 mg/L 1.58883248730964 -DTXSID5040461 Css 3compartmentss Human 95% 6.25 mg/L 4.124 mg/L 1.51551891367604 -DTXSID5040465 Css 3compartmentss Human 95% 3.864 mg/L 0.04396 mg/L 87.8980891719745 -DTXSID5040540 Css 3compartmentss Human 95% 0.2021 mg/L 0.1273 mg/L 1.58758837391987 -DTXSID5040625 Css 3compartmentss Human 95% 45.63 mg/L 27.1 mg/L 1.68376383763838 -DTXSID5040675 Css 3compartmentss Human 95% 263.2 mg/L 141.2 mg/L 1.86402266288952 -DTXSID5040679 Css 3compartmentss Human 95% 18 mg/L 2.96 mg/L 6.08108108108108 -DTXSID5040700 Css 3compartmentss Human 95% 0.4336 mg/L 0.3026 mg/L 1.43291473892928 -DTXSID5040704 Css 3compartmentss Human 95% 2.9 mg/L 1.829 mg/L 1.58556588299617 -DTXSID5040706 Css 3compartmentss Human 95% 13710 mg/L 7785 mg/L 1.76107899807322 -DTXSID5040708 Css 3compartmentss Human 95% 0.8408 mg/L 0.1988 mg/L 4.22937625754527 -DTXSID5040750 Css 3compartmentss Human 95% 6.688 mg/L 3.889 mg/L 1.71972229364875 -DTXSID5040758 Css 3compartmentss Human 95% 108.5 mg/L 56.83 mg/L 1.90920288579975 -DTXSID5041148 Css 3compartmentss Human 95% 5.032 mg/L 3.035 mg/L 1.65799011532125 -DTXSID5041273 Css 3compartmentss Human 95% 10.89 mg/L 6.713 mg/L 1.62222553254879 -DTXSID5041275 Css 3compartmentss Human 95% 186 mg/L 413.8 mg/L 0.449492508458192 -DTXSID5041279 Css 3compartmentss Human 95% 2.362 mg/L 1.401 mg/L 1.6859386152748 -DTXSID5041306 Css 3compartmentss Human 95% 5.578 mg/L 2.8 mg/L 1.99214285714286 -DTXSID5041308 Css 3compartmentss Human 95% 14.76 mg/L 3.304 mg/L 4.46731234866828 -DTXSID5041356 Css 3compartmentss Human 95% 64.55 mg/L 35.47 mg/L 1.8198477586693 -DTXSID5041431 Css 3compartmentss Human 95% 1.471 mg/L 1.078 mg/L 1.36456400742115 -DTXSID5041437 Css 3compartmentss Human 95% 0.4344 mg/L 0.2322 mg/L 1.87080103359173 -DTXSID5041439 Css 3compartmentss Human 95% 14.49 mg/L 9.637 mg/L 1.5035799522673 -DTXSID5041512 Css 3compartmentss Human 95% 6.747 mg/L 4.725 mg/L 1.42793650793651 -DTXSID5041516 Css 3compartmentss Human 95% 0.06254 mg/L 0.04342 mg/L 1.44035006909258 -DTXSID5041518 Css 3compartmentss Human 95% 0.1242 mg/L 0.07666 mg/L 1.62014088181581 -DTXSID5041560 Css 3compartmentss Human 95% 9.597 mg/L 0.0006839 mg/L 14032.7533265097 -DTXSID5041641 Css 3compartmentss Human 95% 8.009 mg/L 4.664 mg/L 1.71719554030875 -DTXSID5041643 Css 3compartmentss Human 95% 2.592 mg/L 1.52 mg/L 1.70526315789474 -DTXSID5041691 Css 3compartmentss Human 95% 2.186 mg/L 2.037 mg/L 1.07314678448699 -DTXSID5041697 Css 3compartmentss Human 95% 0.9125 mg/L 0.4838 mg/L 1.88610996279454 -DTXSID5041699 Css 3compartmentss Human 95% 2.064 mg/L 1.354 mg/L 1.52437223042836 -DTXSID5041726 Css 3compartmentss Human 95% 5406 mg/L 2448 mg/L 2.20833333333333 -DTXSID5041728 Css 3compartmentss Human 95% 129 mg/L 67.57 mg/L 1.90913127127423 -DTXSID5041772 Css 3compartmentss Human 95% 15.93 mg/L 0.03733 mg/L 426.734529868738 -DTXSID5041774 Css 3compartmentss Human 95% 5.593 mg/L 3.523 mg/L 1.58756741413568 -DTXSID5041778 Css 3compartmentss Human 95% 27.38 mg/L 1.296 mg/L 21.1265432098765 -DTXSID5041803 Css 3compartmentss Human 95% 8.781 mg/L 5.213 mg/L 1.68444273930558 -DTXSID5041809 Css 3compartmentss Human 95% 9.421 mg/L 5.725 mg/L 1.64558951965065 -DTXSID5041851 Css 3compartmentss Human 95% 17.41 mg/L 6.201 mg/L 2.8076116755362 -DTXSID5042083 Css 3compartmentss Human 95% 3.303 mg/L 0.7752 mg/L 4.26083591331269 -DTXSID5042089 Css 3compartmentss Human 95% 26.02 mg/L 5.527 mg/L 4.70779808214221 -DTXSID5042243 Css 3compartmentss Human 95% 244.1 mg/L 69.41 mg/L 3.51678432502521 -DTXSID5042249 Css 3compartmentss Human 95% 26.14 mg/L 21.55 mg/L 1.21299303944316 -DTXSID5042297 Css 3compartmentss Human 95% 0.9161 mg/L 0.0436 mg/L 21.0114678899083 -DTXSID5042299 Css 3compartmentss Human 95% 2.65 mg/L 2.45 mg/L 1.08163265306122 -DTXSID5042320 Css 3compartmentss Human 95% 10.97 mg/L 6.711 mg/L 1.63462971241246 -DTXSID5042322 Css 3compartmentss Human 95% 568 mg/L 739.6 mg/L 0.767982693347755 -DTXSID5042324 Css 3compartmentss Human 95% 257.8 mg/L 142.4 mg/L 1.81039325842697 -DTXSID5042459 Css 3compartmentss Human 95% 0.9699 mg/L 4.52e-07 mg/L 2145796.46017699 -DTXSID5042584 Css 3compartmentss Human 95% 4.031 mg/L 1.516 mg/L 2.6589709762533 -DTXSID5042613 Css 3compartmentss Human 95% 0.3574 mg/L 0.262 mg/L 1.36412213740458 -DTXSID5043714 Css 3compartmentss Human 95% 2.8 mg/L 1.826 mg/L 1.53340635268346 -DTXSID5043895 Css 3compartmentss Human 95% 4.404 mg/L 2.119 mg/L 2.07833883907504 -DTXSID5043897 Css 3compartmentss Human 95% 2.855 mg/L 0.4695 mg/L 6.08093716719915 -DTXSID5044023 Css 3compartmentss Human 95% 0.03752 mg/L 1e-09 mg/L 37520000 -DTXSID5044029 Css 3compartmentss Human 95% 53.7 mg/L 10.73 mg/L 5.00465983224604 -DTXSID5044154 Css 3compartmentss Human 95% 4.494 mg/L 2.867 mg/L 1.56749215207534 -DTXSID5044233 Css 3compartmentss Human 95% 0.001232 mg/L 0 mg/L Inf -DTXSID5044239 Css 3compartmentss Human 95% 3.343 mg/L 2.165 mg/L 1.54411085450346 -DTXSID5044289 Css 3compartmentss Human 95% 0.5415 mg/L 0.3999 mg/L 1.35408852213053 -DTXSID5044314 Css 3compartmentss Human 95% 0.2216 mg/L 0.1999 mg/L 1.10855427713857 -DTXSID5044316 Css 3compartmentss Human 95% 7.666 mg/L 4.611 mg/L 1.66254608544784 -DTXSID5044318 Css 3compartmentss Human 95% 50.74 mg/L 28.52 mg/L 1.77910238429173 -DTXSID5044360 Css 3compartmentss Human 95% 3.968 mg/L 2.304 mg/L 1.72222222222222 -DTXSID5044362 Css 3compartmentss Human 95% 5.786 mg/L 3.541 mg/L 1.6340016944366 -DTXSID5044447 Css 3compartmentss Human 95% 0.1465 mg/L 0.088 mg/L 1.66477272727273 -DTXSID5044491 Css 3compartmentss Human 95% 5.546 mg/L 2.503 mg/L 2.2157411106672 -DTXSID5044493 Css 3compartmentss Human 95% 0.1687 mg/L 0.09676 mg/L 1.74348904505994 -DTXSID5044495 Css 3compartmentss Human 95% 0.3074 mg/L 0.2142 mg/L 1.43510737628385 -DTXSID5044520 Css 3compartmentss Human 95% 6356 mg/L 4159 mg/L 1.52825198364992 -DTXSID5044522 Css 3compartmentss Human 95% 0.738 mg/L 0.4904 mg/L 1.50489396411093 -DTXSID5044526 Css 3compartmentss Human 95% 1.987 mg/L 1.454 mg/L 1.3665749656121 -DTXSID5044528 Css 3compartmentss Human 95% 162.6 mg/L 97.06 mg/L 1.67525242118277 -DTXSID5044570 Css 3compartmentss Human 95% 5.503 mg/L 3.684 mg/L 1.49375678610206 -DTXSID5044572 Css 3compartmentss Human 95% 464.1 mg/L 268.9 mg/L 1.72592041651171 -DTXSID5044576 Css 3compartmentss Human 95% 0.1889 mg/L 0.1161 mg/L 1.62704565030146 -DTXSID5044578 Css 3compartmentss Human 95% 8.009 mg/L 4.664 mg/L 1.71719554030875 -DTXSID5044603 Css 3compartmentss Human 95% 1.319 mg/L 0.8345 mg/L 1.58058717795087 -DTXSID5044605 Css 3compartmentss Human 95% 22.05 mg/L 5.921 mg/L 3.72403310251647 -DTXSID5044607 Css 3compartmentss Human 95% 0.8867 mg/L 0.4592 mg/L 1.9309668989547 -DTXSID5044655 Css 3compartmentss Human 95% 23.77 mg/L 0.6352 mg/L 37.4212846347607 -DTXSID5044734 Css 3compartmentss Human 95% 2.746 mg/L 1.897 mg/L 1.4475487612019 -DTXSID5044738 Css 3compartmentss Human 95% 0.6823 mg/L 0.4044 mg/L 1.68719090009891 -DTXSID5044782 Css 3compartmentss Human 95% 74.07 mg/L 40.85 mg/L 1.81321909424725 -DTXSID5044784 Css 3compartmentss Human 95% 4.659 mg/L 3.322 mg/L 1.40246839253462 -DTXSID5044786 Css 3compartmentss Human 95% 8.834 mg/L 3.113 mg/L 2.83777706392547 -DTXSID5044788 Css 3compartmentss Human 95% 11.45 mg/L 6.076 mg/L 1.88446346280448 -DTXSID5044811 Css 3compartmentss Human 95% 0.173 mg/L 0.127 mg/L 1.36220472440945 -DTXSID5044815 Css 3compartmentss Human 95% 28.85 mg/L 0.598 mg/L 48.2441471571906 -DTXSID5044817 Css 3compartmentss Human 95% 46.62 mg/L 14.11 mg/L 3.30403968816442 -DTXSID5044819 Css 3compartmentss Human 95% 9.51 mg/L 5.881 mg/L 1.6170719265431 -DTXSID5044863 Css 3compartmentss Human 95% 1.935 mg/L 1.238 mg/L 1.56300484652666 -DTXSID5044865 Css 3compartmentss Human 95% 52.24 mg/L 1.44 mg/L 36.2777777777778 -DTXSID5044867 Css 3compartmentss Human 95% 13.44 mg/L 15.52 mg/L 0.865979381443299 -DTXSID5044940 Css 3compartmentss Human 95% 11.38 mg/L 2.955 mg/L 3.85109983079526 -DTXSID5044948 Css 3compartmentss Human 95% 0.4906 mg/L 0.297 mg/L 1.65185185185185 -DTXSID5044992 Css 3compartmentss Human 95% 28.47 mg/L 3.134 mg/L 9.08423739629866 -DTXSID5044994 Css 3compartmentss Human 95% 53.56 mg/L 12.88 mg/L 4.1583850931677 -DTXSID5044998 Css 3compartmentss Human 95% 5.481 mg/L 2.352 mg/L 2.33035714285714 -DTXSID5045043 Css 3compartmentss Human 95% 5.896 mg/L 3.518 mg/L 1.67595224559409 -DTXSID5045091 Css 3compartmentss Human 95% 2.604 mg/L 0.005061 mg/L 514.522821576763 -DTXSID5045093 Css 3compartmentss Human 95% 7.447 mg/L 4.457 mg/L 1.67085483509087 -DTXSID5045099 Css 3compartmentss Human 95% 1.673 mg/L 1.236 mg/L 1.35355987055016 -DTXSID5045120 Css 3compartmentss Human 95% 3.702 mg/L 2.532 mg/L 1.46208530805687 -DTXSID5045122 Css 3compartmentss Human 95% 0.8121 mg/L 0.454 mg/L 1.78876651982379 -DTXSID5045124 Css 3compartmentss Human 95% 297.5 mg/L 188.3 mg/L 1.57992565055762 -DTXSID5045128 Css 3compartmentss Human 95% 0.3743 mg/L 0.2321 mg/L 1.61266695389918 -DTXSID5045170 Css 3compartmentss Human 95% 0.7038 mg/L 0.5353 mg/L 1.31477676069494 -DTXSID5045174 Css 3compartmentss Human 95% 0.2477 mg/L 0.1145 mg/L 2.16331877729258 -DTXSID5045176 Css 3compartmentss Human 95% 4.088 mg/L 0.8162 mg/L 5.00857632933105 -DTXSID5045178 Css 3compartmentss Human 95% 153.2 mg/L 90.08 mg/L 1.70071047957371 -DTXSID5045201 Css 3compartmentss Human 95% 0.8619 mg/L 0.5714 mg/L 1.508400420021 -DTXSID5045203 Css 3compartmentss Human 95% 0.01323 mg/L 0.008214 mg/L 1.61066471877283 -DTXSID5045205 Css 3compartmentss Human 95% 0.8327 mg/L 0.7095 mg/L 1.17364341085271 -DTXSID5045209 Css 3compartmentss Human 95% 1.39 mg/L 0.9284 mg/L 1.49719948298147 -DTXSID5045330 Css 3compartmentss Human 95% 0.1841 mg/L 0.114 mg/L 1.61491228070175 -DTXSID5045332 Css 3compartmentss Human 95% 2.636 mg/L 1.116 mg/L 2.36200716845878 -DTXSID5045380 Css 3compartmentss Human 95% 0.1202 mg/L 0.07017 mg/L 1.7129827561636 -DTXSID5045382 Css 3compartmentss Human 95% 8.032 mg/L 5.1 mg/L 1.57490196078431 -DTXSID5045384 Css 3compartmentss Human 95% 0.7196 mg/L 0.5231 mg/L 1.37564519212388 -DTXSID5045386 Css 3compartmentss Human 95% 0.3715 mg/L 0.2599 mg/L 1.42939592150827 -DTXSID5045388 Css 3compartmentss Human 95% 5.653 mg/L 3.776 mg/L 1.49708686440678 -DTXSID5045413 Css 3compartmentss Human 95% 1.428 mg/L 0.2089 mg/L 6.83580660603159 -DTXSID5045417 Css 3compartmentss Human 95% 1.321 mg/L 0.8758 mg/L 1.50833523635533 -DTXSID5045419 Css 3compartmentss Human 95% 1.42 mg/L 1.033 mg/L 1.37463697967086 -DTXSID5045461 Css 3compartmentss Human 95% 4.217 mg/L 2.68 mg/L 1.57350746268657 -DTXSID5045463 Css 3compartmentss Human 95% 0.02462 mg/L 0.02177 mg/L 1.1309141019752 -DTXSID5045465 Css 3compartmentss Human 95% 5.403 mg/L 3.383 mg/L 1.59710316287319 -DTXSID5045467 Css 3compartmentss Human 95% 0.09964 mg/L 0.03158 mg/L 3.15516149461685 -DTXSID5045469 Css 3compartmentss Human 95% 104.3 mg/L 54.71 mg/L 1.90641564613416 -DTXSID5045540 Css 3compartmentss Human 95% 1.956 mg/L 1.296 mg/L 1.50925925925926 -DTXSID5045544 Css 3compartmentss Human 95% 0.06913 mg/L 2.958e-05 mg/L 2337.05206220419 -DTXSID5045546 Css 3compartmentss Human 95% 14.36 mg/L 8.112 mg/L 1.77021696252465 -DTXSID5045590 Css 3compartmentss Human 95% 0.3338 mg/L 0.1791 mg/L 1.86376326074819 -DTXSID5045594 Css 3compartmentss Human 95% 179.3 mg/L 100.7 mg/L 1.78053624627607 -DTXSID5045596 Css 3compartmentss Human 95% 10.69 mg/L 6.549 mg/L 1.63231027637807 -DTXSID5045598 Css 3compartmentss Human 95% 3.096 mg/L 2.386 mg/L 1.2975691533948 -DTXSID5045623 Css 3compartmentss Human 95% 35.25 mg/L 19.44 mg/L 1.81327160493827 -DTXSID5045625 Css 3compartmentss Human 95% 2.211 mg/L 1.213 mg/L 1.82275350370981 -DTXSID5045671 Css 3compartmentss Human 95% 0.3942 mg/L 0.3902 mg/L 1.01025115325474 -DTXSID5045673 Css 3compartmentss Human 95% 0.9541 mg/L 0.6854 mg/L 1.39203384884739 -DTXSID5045675 Css 3compartmentss Human 95% 5.788 mg/L 3.772 mg/L 1.53446447507953 -DTXSID5045677 Css 3compartmentss Human 95% 0.8949 mg/L 0.6841 mg/L 1.30814208449057 -DTXSID5045679 Css 3compartmentss Human 95% 3.343 mg/L 2.165 mg/L 1.54411085450346 -DTXSID5045700 Css 3compartmentss Human 95% 26.23 mg/L 17.16 mg/L 1.52855477855478 -DTXSID5045702 Css 3compartmentss Human 95% 0.8787 mg/L 0.6388 mg/L 1.37554790231684 -DTXSID5045704 Css 3compartmentss Human 95% 0.5618 mg/L 0.3832 mg/L 1.4660751565762 -DTXSID5045706 Css 3compartmentss Human 95% 0.0699 mg/L 0.03687 mg/L 1.89585028478438 -DTXSID5045708 Css 3compartmentss Human 95% 0.1536 mg/L 0.09244 mg/L 1.66161834703592 -DTXSID5045750 Css 3compartmentss Human 95% 4.071 mg/L 1.212 mg/L 3.35891089108911 -DTXSID5045752 Css 3compartmentss Human 95% 3.156 mg/L 1.781 mg/L 1.77203818079731 -DTXSID5045756 Css 3compartmentss Human 95% 2 mg/L 0.9437 mg/L 2.11931757973932 -DTXSID5045758 Css 3compartmentss Human 95% 0.3067 mg/L 0.1971 mg/L 1.5560629122273 -DTXSID5045831 Css 3compartmentss Human 95% 350.5 mg/L 192.8 mg/L 1.81794605809129 -DTXSID5045833 Css 3compartmentss Human 95% 5.262 mg/L 3.402 mg/L 1.54673721340388 -DTXSID5045835 Css 3compartmentss Human 95% 5.533 mg/L 2.992 mg/L 1.84926470588235 -DTXSID5045839 Css 3compartmentss Human 95% 0.006852 mg/L 0.002401 mg/L 2.85381091211995 -DTXSID5045881 Css 3compartmentss Human 95% 0.05034 mg/L 0.0203 mg/L 2.47980295566502 -DTXSID5045883 Css 3compartmentss Human 95% 0.6666 mg/L 0.4909 mg/L 1.3579140354451 -DTXSID5045885 Css 3compartmentss Human 95% 5.401 mg/L 3.179 mg/L 1.69896193771626 -DTXSID5045887 Css 3compartmentss Human 95% 9.442 mg/L 5.9 mg/L 1.60033898305085 -DTXSID5045889 Css 3compartmentss Human 95% 0.4942 mg/L 5.04e-07 mg/L 980555.555555556 -DTXSID5045910 Css 3compartmentss Human 95% 1.627 mg/L 0.6183 mg/L 2.6314087012777 -DTXSID5045914 Css 3compartmentss Human 95% 5.583 mg/L 3.628 mg/L 1.53886438809261 -DTXSID5045916 Css 3compartmentss Human 95% 0.1635 mg/L 0.02455 mg/L 6.65987780040733 -DTXSID5045960 Css 3compartmentss Human 95% 133.2 mg/L 70.91 mg/L 1.87843745593005 -DTXSID5045962 Css 3compartmentss Human 95% 2.501 mg/L 1.915 mg/L 1.30600522193211 -DTXSID5045964 Css 3compartmentss Human 95% 12.27 mg/L 1.012 mg/L 12.1245059288538 -DTXSID5046011 Css 3compartmentss Human 95% 0.02826 mg/L 0.007906 mg/L 3.57450037945864 -DTXSID5046013 Css 3compartmentss Human 95% 6.172 mg/L 4.012 mg/L 1.53838484546361 -DTXSID5046015 Css 3compartmentss Human 95% 5.733 mg/L 3.628 mg/L 1.58020948180816 -DTXSID5046017 Css 3compartmentss Human 95% 6.606 mg/L 3.573 mg/L 1.84886649874055 -DTXSID5046019 Css 3compartmentss Human 95% 8.852 mg/L 5.485 mg/L 1.61385597082954 -DTXSID5046061 Css 3compartmentss Human 95% 1.27 mg/L 0.6489 mg/L 1.95715826783788 -DTXSID5046063 Css 3compartmentss Human 95% 0.4085 mg/L 0.3056 mg/L 1.33671465968586 -DTXSID5046067 Css 3compartmentss Human 95% 3.486 mg/L 2.116 mg/L 1.64744801512287 -DTXSID5046069 Css 3compartmentss Human 95% 4.694 mg/L 1.534 mg/L 3.0599739243807 -DTXSID5046142 Css 3compartmentss Human 95% 4.561 mg/L 2.813 mg/L 1.62140063988624 -DTXSID5046144 Css 3compartmentss Human 95% 0.1064 mg/L 0.08329 mg/L 1.27746428142634 -DTXSID5046148 Css 3compartmentss Human 95% 2.082 mg/L 1.03 mg/L 2.02135922330097 -DTXSID5046190 Css 3compartmentss Human 95% 3.425 mg/L 2.118 mg/L 1.61709159584514 -DTXSID5046192 Css 3compartmentss Human 95% 11.98 mg/L 8.605 mg/L 1.39221382916909 -DTXSID5046196 Css 3compartmentss Human 95% 5.537 mg/L 2.139 mg/L 2.58859280037401 -DTXSID5046198 Css 3compartmentss Human 95% 0.02715 mg/L 0 mg/L Inf -DTXSID5046221 Css 3compartmentss Human 95% 0.6903 mg/L 0.1918 mg/L 3.59906152241919 -DTXSID5046223 Css 3compartmentss Human 95% 2.097 mg/L 1.265 mg/L 1.65770750988142 -DTXSID5046225 Css 3compartmentss Human 95% 1327 mg/L 771.5 mg/L 1.7200259235256 -DTXSID5046227 Css 3compartmentss Human 95% 19.9 mg/L 1.452 mg/L 13.7052341597796 -DTXSID5046229 Css 3compartmentss Human 95% 64.48 mg/L 85.51 mg/L 0.754063852181031 -DTXSID5046271 Css 3compartmentss Human 95% 0.7718 mg/L 0.5362 mg/L 1.43938828795226 -DTXSID5046273 Css 3compartmentss Human 95% 15.35 mg/L 8.744 mg/L 1.75548947849954 -DTXSID5046275 Css 3compartmentss Human 95% 9.861 mg/L 5.975 mg/L 1.65037656903766 -DTXSID5046277 Css 3compartmentss Human 95% 51.03 mg/L 35.69 mg/L 1.42981227234519 -DTXSID5046279 Css 3compartmentss Human 95% 15.23 mg/L 6.613 mg/L 2.30303946771511 -DTXSID5046300 Css 3compartmentss Human 95% 10.86 mg/L 5.66 mg/L 1.91872791519435 -DTXSID5046306 Css 3compartmentss Human 95% 0.166 mg/L 0.1221 mg/L 1.35954135954136 -DTXSID5046308 Css 3compartmentss Human 95% 1.935 mg/L 1.546 mg/L 1.251617076326 -DTXSID5046352 Css 3compartmentss Human 95% 1.275 mg/L 0.7838 mg/L 1.62669048226588 -DTXSID5046354 Css 3compartmentss Human 95% 680.7 mg/L 398.1 mg/L 1.70987189148455 -DTXSID5046356 Css 3compartmentss Human 95% 4.95 mg/L 3.433 mg/L 1.44188756189921 -DTXSID5046358 Css 3compartmentss Human 95% 323.8 mg/L 127.2 mg/L 2.54559748427673 -DTXSID5046433 Css 3compartmentss Human 95% 3.215 mg/L 2.329 mg/L 1.38042078145127 -DTXSID5046435 Css 3compartmentss Human 95% 5.098 mg/L 3.399 mg/L 1.49985289791115 -DTXSID5046437 Css 3compartmentss Human 95% 8.064 mg/L 5.095 mg/L 1.58272816486752 -DTXSID5046439 Css 3compartmentss Human 95% 48.36 mg/L 25.03 mg/L 1.93208150219736 -DTXSID5046481 Css 3compartmentss Human 95% 85.24 mg/L 1.231 mg/L 69.2445166531275 -DTXSID5046483 Css 3compartmentss Human 95% 22.22 mg/L 11.14 mg/L 1.99461400359066 -DTXSID5046485 Css 3compartmentss Human 95% 1.07 mg/L 0.8051 mg/L 1.32902745000621 -DTXSID5046487 Css 3compartmentss Human 95% 4.988 mg/L 2.785 mg/L 1.79102333931777 -DTXSID5046489 Css 3compartmentss Human 95% 0.2958 mg/L 0.1817 mg/L 1.62795817281233 -DTXSID5046510 Css 3compartmentss Human 95% 5.489 mg/L 3.145 mg/L 1.74531001589825 -DTXSID5046512 Css 3compartmentss Human 95% 5.263 mg/L 3.503 mg/L 1.50242649157865 -DTXSID5046518 Css 3compartmentss Human 95% NA mg/L NA mg/L NA -DTXSID5046562 Css 3compartmentss Human 95% 1.692 mg/L 1.205 mg/L 1.40414937759336 -DTXSID5046564 Css 3compartmentss Human 95% 73.81 mg/L 41.12 mg/L 1.79499027237354 -DTXSID5046568 Css 3compartmentss Human 95% 8.43 mg/L 5.241 mg/L 1.60847166571265 -DTXSID5046641 Css 3compartmentss Human 95% 0.09906 mg/L 0.03155 mg/L 3.13977812995246 -DTXSID5046643 Css 3compartmentss Human 95% 8.075 mg/L 4.928 mg/L 1.63859577922078 -DTXSID5046647 Css 3compartmentss Human 95% 1.65 mg/L 0.9906 mg/L 1.6656571774682 -DTXSID5046649 Css 3compartmentss Human 95% 23.96 mg/L 44.79 mg/L 0.534940835007814 -DTXSID5046691 Css 3compartmentss Human 95% 12.94 mg/L 2.066 mg/L 6.26331074540174 -DTXSID5046693 Css 3compartmentss Human 95% 0.4705 mg/L 0.3162 mg/L 1.48798228969007 -DTXSID5046695 Css 3compartmentss Human 95% 2.531 mg/L 2.579 mg/L 0.981388134936022 -DTXSID5046697 Css 3compartmentss Human 95% 1.061 mg/L 0.843 mg/L 1.25860023724792 -DTXSID5046699 Css 3compartmentss Human 95% 0.1456 mg/L 0.1109 mg/L 1.31289449954914 -DTXSID5046720 Css 3compartmentss Human 95% 3022 mg/L 9739 mg/L 0.310298798644625 -DTXSID5046722 Css 3compartmentss Human 95% 31.59 mg/L 17.61 mg/L 1.793867120954 -DTXSID5046724 Css 3compartmentss Human 95% 12.44 mg/L 0.02088 mg/L 595.785440613027 -DTXSID5046726 Css 3compartmentss Human 95% 4.156 mg/L 0.23 mg/L 18.0695652173913 -DTXSID5046728 Css 3compartmentss Human 95% 40.77 mg/L 20.83 mg/L 1.95727316370619 -DTXSID5046770 Css 3compartmentss Human 95% 0.7273 mg/L 0.433 mg/L 1.6796766743649 -DTXSID5046772 Css 3compartmentss Human 95% 6.489 mg/L 0.5392 mg/L 12.0344955489614 -DTXSID5046776 Css 3compartmentss Human 95% 236.2 mg/L 130.3 mg/L 1.81273983115886 -DTXSID5046778 Css 3compartmentss Human 95% 14.26 mg/L 5.79 mg/L 2.46286701208981 -DTXSID5046801 Css 3compartmentss Human 95% 6.17 mg/L 2.405 mg/L 2.56548856548857 -DTXSID5046803 Css 3compartmentss Human 95% 3.476 mg/L 2.025 mg/L 1.71654320987654 -DTXSID5046805 Css 3compartmentss Human 95% 1.554 mg/L 0.7944 mg/L 1.95619335347432 -DTXSID5046807 Css 3compartmentss Human 95% 0.01402 mg/L 0 mg/L Inf -DTXSID5046851 Css 3compartmentss Human 95% 1564 mg/L 936.6 mg/L 1.66986974161862 -DTXSID5046853 Css 3compartmentss Human 95% 90.04 mg/L 30.96 mg/L 2.90826873385013 -DTXSID5046855 Css 3compartmentss Human 95% 0.005183 mg/L 0.00469 mg/L 1.10511727078891 -DTXSID5046857 Css 3compartmentss Human 95% 10.33 mg/L 5.389 mg/L 1.91686769344962 -DTXSID5046859 Css 3compartmentss Human 95% 0.1478 mg/L 0.09244 mg/L 1.59887494591086 -DTXSID5046938 Css 3compartmentss Human 95% 3.257 mg/L 2.084 mg/L 1.56285988483685 -DTXSID5046980 Css 3compartmentss Human 95% 9.584 mg/L 5.904 mg/L 1.62330623306233 -DTXSID5046986 Css 3compartmentss Human 95% 7.144 mg/L 4.462 mg/L 1.6010757507844 -DTXSID5046988 Css 3compartmentss Human 95% 5.742 mg/L 3.704 mg/L 1.55021598272138 -DTXSID5047031 Css 3compartmentss Human 95% 9.315 mg/L 1.501 mg/L 6.20586275816123 -DTXSID5047033 Css 3compartmentss Human 95% NA mg/L NA mg/L NA -DTXSID5047037 Css 3compartmentss Human 95% 30.32 mg/L 18.46 mg/L 1.64247020585049 -DTXSID5047039 Css 3compartmentss Human 95% 8.876 mg/L 6.025 mg/L 1.47319502074689 -DTXSID5047085 Css 3compartmentss Human 95% 1.327 mg/L 0.8405 mg/L 1.57882212968471 -DTXSID5047087 Css 3compartmentss Human 95% 0.04888 mg/L 0.03425 mg/L 1.42715328467153 -DTXSID5047110 Css 3compartmentss Human 95% 27.93 mg/L 0.009446 mg/L 2956.80711412238 -DTXSID5047112 Css 3compartmentss Human 95% 0.02565 mg/L 0.0001899 mg/L 135.071090047393 -DTXSID5047116 Css 3compartmentss Human 95% 4.167 mg/L 4.506 mg/L 0.924766977363515 -DTXSID5047118 Css 3compartmentss Human 95% 4.467 mg/L 3.069 mg/L 1.455522971652 -DTXSID5047164 Css 3compartmentss Human 95% 8.144 mg/L 5.559 mg/L 1.46501169275049 -DTXSID5047166 Css 3compartmentss Human 95% 0.6196 mg/L 0.562 mg/L 1.10249110320285 -DTXSID5047168 Css 3compartmentss Human 95% 20.39 mg/L 5.726 mg/L 3.5609500523926 -DTXSID5047241 Css 3compartmentss Human 95% 6.136 mg/L 3.81 mg/L 1.61049868766404 -DTXSID5047243 Css 3compartmentss Human 95% 102.5 mg/L 63.56 mg/L 1.61264946507237 -DTXSID5047249 Css 3compartmentss Human 95% 87.28 mg/L 40.29 mg/L 2.1662943658476 -DTXSID5047291 Css 3compartmentss Human 95% 0.4187 mg/L 0.219 mg/L 1.91187214611872 -DTXSID5047295 Css 3compartmentss Human 95% 3.6 mg/L 1.405 mg/L 2.56227758007117 -DTXSID5047297 Css 3compartmentss Human 95% 40.6 mg/L 4.122 mg/L 9.84958757884522 -DTXSID5047299 Css 3compartmentss Human 95% 1.122 mg/L 0.009852 mg/L 113.885505481121 -DTXSID5047320 Css 3compartmentss Human 95% 85.79 mg/L 4.575 mg/L 18.751912568306 -DTXSID5047322 Css 3compartmentss Human 95% 12.61 mg/L 2.904 mg/L 4.34228650137741 -DTXSID5047324 Css 3compartmentss Human 95% 2.923 mg/L 1.548 mg/L 1.88824289405685 -DTXSID5047328 Css 3compartmentss Human 95% 1364 mg/L 766.1 mg/L 1.78044641691685 -DTXSID5047372 Css 3compartmentss Human 95% 21.72 mg/L 5.658 mg/L 3.83881230116649 -DTXSID5047376 Css 3compartmentss Human 95% 474 mg/L 275.8 mg/L 1.71863669325598 -DTXSID5047451 Css 3compartmentss Human 95% 45.13 mg/L 24.98 mg/L 1.806645316253 -DTXSID5047459 Css 3compartmentss Human 95% 10.61 mg/L 6.461 mg/L 1.64216065624516 -DTXSID5047530 Css 3compartmentss Human 95% 1.675 mg/L 0.8534 mg/L 1.96273728614952 -DTXSID5047538 Css 3compartmentss Human 95% 4.616 mg/L 0.9609 mg/L 4.80382974294932 -DTXSID5047584 Css 3compartmentss Human 95% 4.038 mg/L 1.712 mg/L 2.35864485981308 -DTXSID5047611 Css 3compartmentss Human 95% 7.041 mg/L 5.283 mg/L 1.33276547416241 -DTXSID5047661 Css 3compartmentss Human 95% 1.191 mg/L 0.903 mg/L 1.31893687707641 -DTXSID5047665 Css 3compartmentss Human 95% 16.14 mg/L 9.274 mg/L 1.74034936381281 -DTXSID5047790 Css 3compartmentss Human 95% 1.179 mg/L 0.4566 mg/L 2.58212877792378 -DTXSID5047796 Css 3compartmentss Human 95% 7.33 mg/L 4.6 mg/L 1.59347826086957 -DTXSID5047825 Css 3compartmentss Human 95% 4.405 mg/L 0.8915 mg/L 4.94111048794167 -DTXSID5047829 Css 3compartmentss Human 95% 5.159 mg/L 3.335 mg/L 1.54692653673163 -DTXSID5047879 Css 3compartmentss Human 95% 4.432 mg/L 2.426 mg/L 1.82687551525144 -DTXSID5047900 Css 3compartmentss Human 95% 0.00525 mg/L 0 mg/L Inf -DTXSID5047902 Css 3compartmentss Human 95% 5.288 mg/L 3.496 mg/L 1.51258581235698 -DTXSID5047904 Css 3compartmentss Human 95% 0.01001 mg/L 6.158e-05 mg/L 162.552776875609 -DTXSID5047950 Css 3compartmentss Human 95% 0.00673 mg/L 0 mg/L Inf -DTXSID5047954 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID5047956 Css 3compartmentss Human 95% 147.1 mg/L 78.97 mg/L 1.86273268329745 -DTXSID5048180 Css 3compartmentss Human 95% 1.379 mg/L 0.7939 mg/L 1.73699458370072 -DTXSID5048184 Css 3compartmentss Human 95% 3.861 mg/L 1.61 mg/L 2.39813664596273 -DTXSID5048186 Css 3compartmentss Human 95% 21 mg/L 0.1567 mg/L 134.01403956605 -DTXSID5048421 Css 3compartmentss Human 95% 2.74 mg/L 2.45 mg/L 1.11836734693878 -DTXSID5048506 Css 3compartmentss Human 95% 9.559 mg/L 3.52 mg/L 2.715625 -DTXSID5048631 Css 3compartmentss Human 95% 0.01822 mg/L 0.009536 mg/L 1.91065436241611 -DTXSID5048633 Css 3compartmentss Human 95% 0.02244 mg/L 0.01025 mg/L 2.18926829268293 -DTXSID5048635 Css 3compartmentss Human 95% 76.01 mg/L 170.6 mg/L 0.445545134818288 -DTXSID5048637 Css 3compartmentss Human 95% 10.14 mg/L 4.875 mg/L 2.08 -DTXSID5048639 Css 3compartmentss Human 95% 60.06 mg/L 38.2 mg/L 1.57225130890052 -DTXSID5048681 Css 3compartmentss Human 95% 4.759 mg/L 3.481 mg/L 1.36713588049411 -DTXSID5048683 Css 3compartmentss Human 95% 0.2191 mg/L 0.005951 mg/L 36.8173416232566 -DTXSID5048685 Css 3compartmentss Human 95% 5.526 mg/L 2.762 mg/L 2.00072411296162 -DTXSID5048687 Css 3compartmentss Human 95% 0.002802 mg/L 0.001762 mg/L 1.59023836549376 -DTXSID5048689 Css 3compartmentss Human 95% 0.3064 mg/L 0.2654 mg/L 1.15448379804069 -DTXSID5048710 Css 3compartmentss Human 95% 1.313 mg/L 0.9803 mg/L 1.33938590227481 -DTXSID5048712 Css 3compartmentss Human 95% 1.204 mg/L 2.89e-07 mg/L 4166089.96539792 -DTXSID5048714 Css 3compartmentss Human 95% 2.375 mg/L 1.26 mg/L 1.88492063492063 -DTXSID5048716 Css 3compartmentss Human 95% 9.097 mg/L 1.116 mg/L 8.15143369175627 -DTXSID5048718 Css 3compartmentss Human 95% 4.577 mg/L 2.853 mg/L 1.60427620049071 -DTXSID5048760 Css 3compartmentss Human 95% 8.605 mg/L 3.552 mg/L 2.42257882882883 -DTXSID5048762 Css 3compartmentss Human 95% 0.8917 mg/L 0.6907 mg/L 1.29100912118141 -DTXSID5048764 Css 3compartmentss Human 95% 17.1 mg/L 1.334 mg/L 12.8185907046477 -DTXSID5048766 Css 3compartmentss Human 95% 4.346 mg/L 4.28 mg/L 1.01542056074766 -DTXSID5048768 Css 3compartmentss Human 95% 0.882 mg/L 0.5943 mg/L 1.48409893992933 -DTXSID5048841 Css 3compartmentss Human 95% 30.19 mg/L 16.64 mg/L 1.81430288461538 -DTXSID5048843 Css 3compartmentss Human 95% 6.002 mg/L 4.421 mg/L 1.35761140013572 -DTXSID5048845 Css 3compartmentss Human 95% 3.684 mg/L 1.946 mg/L 1.89311408016444 -DTXSID5048847 Css 3compartmentss Human 95% 2.193 mg/L 1.336 mg/L 1.64146706586826 -DTXSID5048849 Css 3compartmentss Human 95% 7.625 mg/L 1.2 mg/L 6.35416666666667 -DTXSID5048891 Css 3compartmentss Human 95% 0.3422 mg/L 0.2225 mg/L 1.53797752808989 -DTXSID5048893 Css 3compartmentss Human 95% 0.04219 mg/L 0.03189 mg/L 1.32298526183757 -DTXSID5048895 Css 3compartmentss Human 95% 0.7505 mg/L 0.3446 mg/L 2.17788740568775 -DTXSID5048897 Css 3compartmentss Human 95% 1.031 mg/L 0.1398 mg/L 7.37482117310443 -DTXSID5048899 Css 3compartmentss Human 95% 0.4542 mg/L 0.2936 mg/L 1.54700272479564 -DTXSID5048920 Css 3compartmentss Human 95% 1.047 mg/L 0.3073 mg/L 3.40709404490726 -DTXSID5048922 Css 3compartmentss Human 95% 1.597 mg/L 0.5732 mg/L 2.78611304954641 -DTXSID5048924 Css 3compartmentss Human 95% 7.38 mg/L 1.039 mg/L 7.10298363811357 -DTXSID5048926 Css 3compartmentss Human 95% 1.347 mg/L 0.06223 mg/L 21.6455085971396 -DTXSID5048928 Css 3compartmentss Human 95% 2.509 mg/L 1.025 mg/L 2.44780487804878 -DTXSID5048970 Css 3compartmentss Human 95% 0.06883 mg/L 1e-09 mg/L 68830000 -DTXSID5048972 Css 3compartmentss Human 95% 5.486 mg/L 3.697 mg/L 1.48390586962402 -DTXSID5048974 Css 3compartmentss Human 95% 2.289 mg/L 1.209 mg/L 1.89330024813896 -DTXSID5048976 Css 3compartmentss Human 95% 5.575 mg/L 3.628 mg/L 1.53665931642778 -DTXSID5049021 Css 3compartmentss Human 95% 2.899 mg/L 0.0005775 mg/L 5019.91341991342 -DTXSID5049023 Css 3compartmentss Human 95% 7.144 mg/L 4.462 mg/L 1.6010757507844 -DTXSID5049025 Css 3compartmentss Human 95% 102.5 mg/L 63.56 mg/L 1.61264946507237 -DTXSID5049027 Css 3compartmentss Human 95% 11.99 mg/L 2.491 mg/L 4.81332798073063 -DTXSID5049029 Css 3compartmentss Human 95% 11.53 mg/L 6.287 mg/L 1.83394305710196 -DTXSID5049071 Css 3compartmentss Human 95% 301.5 mg/L 400.9 mg/L 0.752057869792966 -DTXSID5049073 Css 3compartmentss Human 95% 21.49 mg/L 2.464 mg/L 8.72159090909091 -DTXSID5049075 Css 3compartmentss Human 95% 2.988 mg/L 1.839 mg/L 1.62479608482871 -DTXSID5049077 Css 3compartmentss Human 95% 940.1 mg/L 483.8 mg/L 1.94315832988838 -DTXSID5049079 Css 3compartmentss Human 95% 0.005464 mg/L 0.003519 mg/L 1.55271383915885 -DTXSID5049235 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID5049239 Css 3compartmentss Human 95% 5.933 mg/L 3.798 mg/L 1.56213796735124 -DTXSID5049287 Css 3compartmentss Human 95% 11.81 mg/L 10.86 mg/L 1.08747697974217 -DTXSID5049316 Css 3compartmentss Human 95% 3.071 mg/L 2.205 mg/L 1.39274376417234 -DTXSID5049318 Css 3compartmentss Human 95% 4.913 mg/L 2.056 mg/L 2.38959143968872 -DTXSID5049362 Css 3compartmentss Human 95% 4.203 mg/L 2.772 mg/L 1.51623376623377 -DTXSID5050426 Css 3compartmentss Human 95% 0.06787 mg/L 0.04034 mg/L 1.6824491819534 -DTXSID5051440 Css 3compartmentss Human 95% 0.1959 mg/L 0.1612 mg/L 1.21526054590571 -DTXSID5051444 Css 3compartmentss Human 95% 9 mg/L 2.686 mg/L 3.35070737155622 -DTXSID5051446 Css 3compartmentss Human 95% 1.624 mg/L 1.032 mg/L 1.57364341085271 -DTXSID5051650 Css 3compartmentss Human 95% 11980 mg/L 9736 mg/L 1.23048479868529 -DTXSID5051999 Css 3compartmentss Human 95% 28.41 mg/L 12.79 mg/L 2.22126661454261 -DTXSID5052042 Css 3compartmentss Human 95% 1.289 mg/L 0.7375 mg/L 1.74779661016949 -DTXSID5052254 Css 3compartmentss Human 95% 2.211 mg/L 1.447 mg/L 1.52798894263994 -DTXSID5052460 Css 3compartmentss Human 95% 14.91 mg/L 8.715 mg/L 1.71084337349398 -DTXSID5052591 Css 3compartmentss Human 95% 0.1788 mg/L 0.1061 mg/L 1.68520263901979 -DTXSID5052593 Css 3compartmentss Human 95% 2.004 mg/L 1.542 mg/L 1.29961089494163 -DTXSID5052595 Css 3compartmentss Human 95% 1.442 mg/L 1.03 mg/L 1.4 -DTXSID5052597 Css 3compartmentss Human 95% 5.494 mg/L 3.466 mg/L 1.58511252163878 -DTXSID5052620 Css 3compartmentss Human 95% 0.05223 mg/L 0.02963 mg/L 1.76274046574418 -DTXSID5052672 Css 3compartmentss Human 95% 4.558 mg/L 4.85 mg/L 0.93979381443299 -DTXSID5052832 Css 3compartmentss Human 95% 68.58 mg/L 6.677e-05 mg/L 1027107.98262693 -DTXSID5052838 Css 3compartmentss Human 95% 19.72 mg/L 10.86 mg/L 1.8158379373849 -DTXSID5052884 Css 3compartmentss Human 95% 4.853 mg/L 3.33 mg/L 1.45735735735736 -DTXSID5057620 Css 3compartmentss Human 95% 0.9452 mg/L 0.6541 mg/L 1.4450389848647 -DTXSID5057622 Css 3compartmentss Human 95% 0.5446 mg/L 0.159 mg/L 3.4251572327044 -DTXSID5057624 Css 3compartmentss Human 95% 0.3294 mg/L 0.2355 mg/L 1.39872611464968 -DTXSID5057626 Css 3compartmentss Human 95% 1.194 mg/L 0.01444 mg/L 82.6869806094183 -DTXSID5057628 Css 3compartmentss Human 95% 0.2227 mg/L 0.1395 mg/L 1.59641577060932 -DTXSID5057670 Css 3compartmentss Human 95% 0.09288 mg/L 0.06558 mg/L 1.41628545288198 -DTXSID5057672 Css 3compartmentss Human 95% 1.712 mg/L 0.7426 mg/L 2.30541341233504 -DTXSID5057674 Css 3compartmentss Human 95% 5.313 mg/L 2.863 mg/L 1.85574572127139 -DTXSID5057676 Css 3compartmentss Human 95% 12.08 mg/L 9.118 mg/L 1.32485194121518 -DTXSID5057678 Css 3compartmentss Human 95% 12.74 mg/L 0.01686 mg/L 755.634638196916 -DTXSID5057701 Css 3compartmentss Human 95% 0.1288 mg/L 0.07655 mg/L 1.68256041802743 -DTXSID5057703 Css 3compartmentss Human 95% 0.3648 mg/L 0.07702 mg/L 4.73643209555959 -DTXSID5057705 Css 3compartmentss Human 95% 5.565 mg/L 3.733 mg/L 1.49075810340209 -DTXSID5057709 Css 3compartmentss Human 95% 19.98 mg/L 11.75 mg/L 1.70042553191489 -DTXSID5057751 Css 3compartmentss Human 95% 1.54 mg/L 0.2419 mg/L 6.36626705250103 -DTXSID5057753 Css 3compartmentss Human 95% 35.38 mg/L 8.889 mg/L 3.98020024749691 -DTXSID5057755 Css 3compartmentss Human 95% 0.7482 mg/L 0.4631 mg/L 1.61563377240337 -DTXSID5057757 Css 3compartmentss Human 95% 2.624 mg/L 1.543 mg/L 1.70058327932599 -DTXSID5057759 Css 3compartmentss Human 95% 4.668 mg/L 1.769 mg/L 2.63877897117015 -DTXSID5057830 Css 3compartmentss Human 95% 5.511 mg/L 3.043 mg/L 1.81104173512981 -DTXSID5057832 Css 3compartmentss Human 95% 3.019 mg/L 1.108 mg/L 2.72472924187726 -DTXSID5057834 Css 3compartmentss Human 95% 10.96 mg/L 4.874 mg/L 2.24866639310628 -DTXSID5057836 Css 3compartmentss Human 95% 8.041 mg/L 5.369 mg/L 1.49767181970572 -DTXSID5057838 Css 3compartmentss Human 95% 7.603 mg/L 4.648 mg/L 1.63575731497418 -DTXSID50861300 Css 3compartmentss Human 95% 84.72 mg/L 37.46 mg/L 2.26161238654565 -DTXSID50870351 Css 3compartmentss Human 95% 0.7692 mg/L 0.7515 mg/L 1.02355289421158 -DTXSID50873382 Css 3compartmentss Human 95% 244.5 mg/L 115.8 mg/L 2.11139896373057 -DTXSID60194378 Css 3compartmentss Human 95% 40.98 mg/L 23.22 mg/L 1.76485788113695 -DTXSID6020014 Css 3compartmentss Human 95% 7.696 mg/L 4.931 mg/L 1.56073818698033 -DTXSID6020062 Css 3compartmentss Human 95% 4.645 mg/L 2.767 mg/L 1.67871340802313 -DTXSID6020064 Css 3compartmentss Human 95% 1.961 mg/L 1.196 mg/L 1.63963210702341 -DTXSID6020066 Css 3compartmentss Human 95% 0.5159 mg/L 0.4 mg/L 1.28975 -DTXSID6020068 Css 3compartmentss Human 95% 3.962 mg/L 1.686 mg/L 2.34994068801898 -DTXSID6020141 Css 3compartmentss Human 95% 3.111 mg/L 3.145 mg/L 0.989189189189189 -DTXSID6020143 Css 3compartmentss Human 95% 16.23 mg/L 9.891 mg/L 1.64088565362451 -DTXSID6020145 Css 3compartmentss Human 95% 5.739 mg/L 3.204 mg/L 1.79119850187266 -DTXSID6020147 Css 3compartmentss Human 95% 8.241 mg/L 5.369 mg/L 1.53492270441423 -DTXSID6020149 Css 3compartmentss Human 95% 0.2452 mg/L 0.2469 mg/L 0.993114621304172 -DTXSID6020193 Css 3compartmentss Human 95% 7.61 mg/L 5.381 mg/L 1.41423527225423 -DTXSID6020197 Css 3compartmentss Human 95% 1.818 mg/L 0.8697 mg/L 2.09037599172128 -DTXSID6020220 Css 3compartmentss Human 95% 3.177 mg/L 2.682 mg/L 1.18456375838926 -DTXSID6020222 Css 3compartmentss Human 95% 2.522 mg/L 2.601 mg/L 0.96962706651288 -DTXSID6020224 Css 3compartmentss Human 95% 5.875 mg/L 3.819 mg/L 1.53836082744174 -DTXSID6020226 Css 3compartmentss Human 95% 12.7 mg/L 7.72 mg/L 1.64507772020725 -DTXSID6020274 Css 3compartmentss Human 95% 5.211 mg/L 3.446 mg/L 1.51218804410911 -DTXSID6020276 Css 3compartmentss Human 95% 0.4978 mg/L 0.3085 mg/L 1.61361426256078 -DTXSID6020278 Css 3compartmentss Human 95% 12.88 mg/L 10.2 mg/L 1.26274509803922 -DTXSID6020309 Css 3compartmentss Human 95% 2.299 mg/L 1.479 mg/L 1.55442866801893 -DTXSID6020355 Css 3compartmentss Human 95% 9.421 mg/L 5.725 mg/L 1.64558951965065 -DTXSID6020357 Css 3compartmentss Human 95% 0.09476 mg/L 0.05883 mg/L 1.61074281828999 -DTXSID6020359 Css 3compartmentss Human 95% 2.97 mg/L 3.532 mg/L 0.840883352208381 -DTXSID6020432 Css 3compartmentss Human 95% 1.001 mg/L 0.4504 mg/L 2.22246891651865 -DTXSID6020480 Css 3compartmentss Human 95% 0.00843 mg/L 0.006091 mg/L 1.38400919389263 -DTXSID6020484 Css 3compartmentss Human 95% 2.645 mg/L 1.344 mg/L 1.96800595238095 -DTXSID6020511 Css 3compartmentss Human 95% 1.154 mg/L 0.6435 mg/L 1.79331779331779 -DTXSID6020513 Css 3compartmentss Human 95% 7.282 mg/L 4.559 mg/L 1.59728010528625 -DTXSID6020515 Css 3compartmentss Human 95% 5.564 mg/L 3.647 mg/L 1.52563751028242 -DTXSID6020517 Css 3compartmentss Human 95% 4.809 mg/L 3.158 mg/L 1.52279924002533 -DTXSID6020561 Css 3compartmentss Human 95% 2791 mg/L 4542 mg/L 0.614487010127697 -DTXSID6020648 Css 3compartmentss Human 95% 263.7 mg/L 150 mg/L 1.758 -DTXSID6020690 Css 3compartmentss Human 95% 11210 mg/L 9739 mg/L 1.15104220145806 -DTXSID6020692 Css 3compartmentss Human 95% 8.912 mg/L 5.554 mg/L 1.60460929060137 -DTXSID6020696 Css 3compartmentss Human 95% 5.096 mg/L 3.407 mg/L 1.49574405635456 -DTXSID6020721 Css 3compartmentss Human 95% 0.708 mg/L 0.465 mg/L 1.52258064516129 -DTXSID6020771 Css 3compartmentss Human 95% 120.2 mg/L 74.58 mg/L 1.61169214266559 -DTXSID6020777 Css 3compartmentss Human 95% 0.5897 mg/L 0.4324 mg/L 1.36378353376503 -DTXSID6020779 Css 3compartmentss Human 95% 336.9 mg/L 258.6 mg/L 1.30278422273782 -DTXSID6020802 Css 3compartmentss Human 95% 5.08 mg/L 3.129 mg/L 1.62352189197827 -DTXSID6020804 Css 3compartmentss Human 95% 8.737 mg/L 5.759 mg/L 1.51710366383053 -DTXSID6020856 Css 3compartmentss Human 95% 1.541 mg/L 1.263 mg/L 1.22011084718923 -DTXSID6020933 Css 3compartmentss Human 95% 0.4693 mg/L 0.3143 mg/L 1.49315940184537 -DTXSID6020937 Css 3compartmentss Human 95% 18.35 mg/L 27.08 mg/L 0.677621861152142 -DTXSID6020939 Css 3compartmentss Human 95% 5.124 mg/L 2.17 mg/L 2.36129032258065 -DTXSID6020985 Css 3compartmentss Human 95% 2.006 mg/L 1.239 mg/L 1.61904761904762 -DTXSID6021030 Css 3compartmentss Human 95% 13.67 mg/L 7.076 mg/L 1.93188241944601 -DTXSID6021080 Css 3compartmentss Human 95% 5.736 mg/L 3.794 mg/L 1.51186083289404 -DTXSID6021082 Css 3compartmentss Human 95% 12.74 mg/L 6.639 mg/L 1.91896369935231 -DTXSID6021084 Css 3compartmentss Human 95% 0.001405 mg/L 0 mg/L Inf -DTXSID6021086 Css 3compartmentss Human 95% 6.186 mg/L 3.87 mg/L 1.5984496124031 -DTXSID6021113 Css 3compartmentss Human 95% 7.64 mg/L 4.382 mg/L 1.74349612049293 -DTXSID6021117 Css 3compartmentss Human 95% 3.219 mg/L 1.199 mg/L 2.68473728106756 -DTXSID6021163 Css 3compartmentss Human 95% 7.48 mg/L 4.808 mg/L 1.55574043261231 -DTXSID6021165 Css 3compartmentss Human 95% 1.334 mg/L 0.9024 mg/L 1.47828014184397 -DTXSID6021240 Css 3compartmentss Human 95% 3.569 mg/L 2.17e-06 mg/L 1644700.46082949 -DTXSID6021244 Css 3compartmentss Human 95% 90.37 mg/L 53.15 mg/L 1.7002822201317 -DTXSID6021246 Css 3compartmentss Human 95% 0.2963 mg/L 0.2235 mg/L 1.32572706935123 -DTXSID6021248 Css 3compartmentss Human 95% 28.06 mg/L 3.018 mg/L 9.29754804506296 -DTXSID6021290 Css 3compartmentss Human 95% 12.97 mg/L 7.935 mg/L 1.63453056080655 -DTXSID6021292 Css 3compartmentss Human 95% 7.922 mg/L 4.381 mg/L 1.80826295366355 -DTXSID6021294 Css 3compartmentss Human 95% 1.048 mg/L 0.6581 mg/L 1.59246315149673 -DTXSID6021296 Css 3compartmentss Human 95% 21.97 mg/L 11.21 mg/L 1.95985727029438 -DTXSID6021321 Css 3compartmentss Human 95% 7.63 mg/L 4.939 mg/L 1.54484713504758 -DTXSID6021327 Css 3compartmentss Human 95% 5.619 mg/L 1.634e-06 mg/L 3438800.48959608 -DTXSID6021371 Css 3compartmentss Human 95% 0.5721 mg/L 0.3385 mg/L 1.69010339734121 -DTXSID6021373 Css 3compartmentss Human 95% 6.63 mg/L 4.436 mg/L 1.49458972046889 -DTXSID6021375 Css 3compartmentss Human 95% 1.564 mg/L 3.598e-05 mg/L 43468.5936631462 -DTXSID6021379 Css 3compartmentss Human 95% 2.899 mg/L 1.797 mg/L 1.61324429604897 -DTXSID6021404 Css 3compartmentss Human 95% 0.496 mg/L 0.2387 mg/L 2.07792207792208 -DTXSID6021408 Css 3compartmentss Human 95% 6297 mg/L 7902 mg/L 0.796886864085042 -DTXSID6021450 Css 3compartmentss Human 95% 5.827 mg/L 2.468 mg/L 2.36102106969206 -DTXSID6021456 Css 3compartmentss Human 95% 50.24 mg/L 27.89 mg/L 1.80136249551811 -DTXSID6021458 Css 3compartmentss Human 95% 0.7719 mg/L 0.4903 mg/L 1.57434223944524 -DTXSID6021581 Css 3compartmentss Human 95% 9.114 mg/L 5.662 mg/L 1.60967855881314 -DTXSID6021583 Css 3compartmentss Human 95% 3.37 mg/L 2.279 mg/L 1.47871873628785 -DTXSID6021585 Css 3compartmentss Human 95% 7.547 mg/L 4.782 mg/L 1.57820995399414 -DTXSID6021610 Css 3compartmentss Human 95% 14.19 mg/L 8.544 mg/L 1.66081460674157 -DTXSID6021618 Css 3compartmentss Human 95% 42.95 mg/L 25.28 mg/L 1.69897151898734 -DTXSID6021666 Css 3compartmentss Human 95% 466 mg/L 555 mg/L 0.83963963963964 -DTXSID6021668 Css 3compartmentss Human 95% 6.931 mg/L 4.999 mg/L 1.38647729545909 -DTXSID6021741 Css 3compartmentss Human 95% 5.788 mg/L 4.78 mg/L 1.21087866108787 -DTXSID6021793 Css 3compartmentss Human 95% 54.6 mg/L 33.36 mg/L 1.63669064748201 -DTXSID6021795 Css 3compartmentss Human 95% 11.85 mg/L 8.014 mg/L 1.47866234090342 -DTXSID6021822 Css 3compartmentss Human 95% 5.477 mg/L 3.943 mg/L 1.38904387522191 -DTXSID6021824 Css 3compartmentss Human 95% 33.62 mg/L 8.028 mg/L 4.18784255107125 -DTXSID6021828 Css 3compartmentss Human 95% 7.091 mg/L 4.756 mg/L 1.49095878889823 -DTXSID6021872 Css 3compartmentss Human 95% 0.8976 mg/L 0.5908 mg/L 1.51929587000677 -DTXSID6021907 Css 3compartmentss Human 95% 6.429 mg/L 3.979 mg/L 1.61573259612968 -DTXSID6021909 Css 3compartmentss Human 95% 3.764 mg/L 2.505 mg/L 1.50259481037924 -DTXSID6021953 Css 3compartmentss Human 95% 0.5927 mg/L 0.3132 mg/L 1.89240102171137 -DTXSID6021957 Css 3compartmentss Human 95% 3.923 mg/L 1.391 mg/L 2.82027318475917 -DTXSID6021959 Css 3compartmentss Human 95% 590.6 mg/L 577.8 mg/L 1.02215299411561 -DTXSID6022000 Css 3compartmentss Human 95% 5.288 mg/L 3.496 mg/L 1.51258581235698 -DTXSID6022002 Css 3compartmentss Human 95% 1.35 mg/L 1.045 mg/L 1.29186602870813 -DTXSID6022008 Css 3compartmentss Human 95% 6.675 mg/L 4.738 mg/L 1.40882228788518 -DTXSID6022133 Css 3compartmentss Human 95% 0.3264 mg/L 0.2045 mg/L 1.5960880195599 -DTXSID6022137 Css 3compartmentss Human 95% 4.313 mg/L 2.982 mg/L 1.44634473507713 -DTXSID6022187 Css 3compartmentss Human 95% 0.4057 mg/L 0.2152 mg/L 1.88522304832714 -DTXSID6022341 Css 3compartmentss Human 95% 13.22 mg/L 6.229 mg/L 2.12233103226842 -DTXSID6022345 Css 3compartmentss Human 95% 17.53 mg/L 0.008108 mg/L 2162.06216082881 -DTXSID6022391 Css 3compartmentss Human 95% 5.877 mg/L 2.543 mg/L 2.31104994101455 -DTXSID6022393 Css 3compartmentss Human 95% 3.774 mg/L 1.486 mg/L 2.53970390309556 -DTXSID6022399 Css 3compartmentss Human 95% 46.43 mg/L 25.85 mg/L 1.79613152804642 -DTXSID6022420 Css 3compartmentss Human 95% 1.285 mg/L 0.8769 mg/L 1.46538944007298 -DTXSID6022422 Css 3compartmentss Human 95% 2.042 mg/L 1.32 mg/L 1.5469696969697 -DTXSID6022474 Css 3compartmentss Human 95% 1.675 mg/L 0.9915 mg/L 1.68935955622794 -DTXSID6022553 Css 3compartmentss Human 95% 2.848 mg/L 0.05299 mg/L 53.745989809398 -DTXSID6022555 Css 3compartmentss Human 95% 4.654 mg/L 2.548 mg/L 1.8265306122449 -DTXSID6022557 Css 3compartmentss Human 95% 2.573 mg/L 1.587 mg/L 1.62129804662886 -DTXSID6022559 Css 3compartmentss Human 95% 7.679 mg/L 4.656 mg/L 1.64926975945017 -DTXSID6022630 Css 3compartmentss Human 95% 16 mg/L 21.54 mg/L 0.74280408542247 -DTXSID6022632 Css 3compartmentss Human 95% 0.7196 mg/L 0.5231 mg/L 1.37564519212388 -DTXSID6022636 Css 3compartmentss Human 95% 4.273 mg/L 2.046 mg/L 2.08846529814272 -DTXSID6022682 Css 3compartmentss Human 95% 2.038 mg/L 1.288 mg/L 1.58229813664596 -DTXSID6022684 Css 3compartmentss Human 95% 4.24 mg/L 1.429 mg/L 2.96710986703989 -DTXSID6022688 Css 3compartmentss Human 95% 3.415 mg/L 0.7945 mg/L 4.29830081812461 -DTXSID6022715 Css 3compartmentss Human 95% 2.627 mg/L 0.02267 mg/L 115.880017644464 -DTXSID6022719 Css 3compartmentss Human 95% 0.2899 mg/L 0.1616 mg/L 1.79393564356436 -DTXSID6022844 Css 3compartmentss Human 95% 17.24 mg/L 0.2914 mg/L 59.1626630061771 -DTXSID6022846 Css 3compartmentss Human 95% 0.3114 mg/L 0.2002 mg/L 1.55544455544456 -DTXSID6022892 Css 3compartmentss Human 95% 2.17 mg/L 1.188 mg/L 1.82659932659933 -DTXSID6022894 Css 3compartmentss Human 95% 1.644 mg/L 0.9453 mg/L 1.73913043478261 -DTXSID6022896 Css 3compartmentss Human 95% 7.836 mg/L 0.551 mg/L 14.2214156079855 -DTXSID6022898 Css 3compartmentss Human 95% 15.38 mg/L 0.4743 mg/L 32.426734134514 -DTXSID6022923 Css 3compartmentss Human 95% 23.17 mg/L 11.65 mg/L 1.98884120171674 -DTXSID6022927 Css 3compartmentss Human 95% 1.445 mg/L 1.202 mg/L 1.20216306156406 -DTXSID6022973 Css 3compartmentss Human 95% 1.987 mg/L 1.257 mg/L 1.58074781225139 -DTXSID6022975 Css 3compartmentss Human 95% 0.7901 mg/L 0.4989 mg/L 1.58368410503107 -DTXSID6022977 Css 3compartmentss Human 95% 5.506 mg/L 2.503 mg/L 2.19976028765481 -DTXSID6023020 Css 3compartmentss Human 95% 0.9838 mg/L 0.6162 mg/L 1.59655955858488 -DTXSID6023024 Css 3compartmentss Human 95% 28.96 mg/L 1.42 mg/L 20.3943661971831 -DTXSID6023028 Css 3compartmentss Human 95% 7.415 mg/L 4.51 mg/L 1.64412416851441 -DTXSID6023076 Css 3compartmentss Human 95% 9.023 mg/L 7.521 mg/L 1.19970748570669 -DTXSID6023078 Css 3compartmentss Human 95% 8.563 mg/L 5.311 mg/L 1.61231406514781 -DTXSID6023101 Css 3compartmentss Human 95% 5.162 mg/L 3.37 mg/L 1.53175074183976 -DTXSID6023103 Css 3compartmentss Human 95% 124.5 mg/L 68.19 mg/L 1.82578090629125 -DTXSID6023109 Css 3compartmentss Human 95% 0.2212 mg/L 0.2034 mg/L 1.08751229105211 -DTXSID6023153 Css 3compartmentss Human 95% 523.5 mg/L 299.3 mg/L 1.74908118944203 -DTXSID6023155 Css 3compartmentss Human 95% 70.46 mg/L 46.39 mg/L 1.51886182366889 -DTXSID6023157 Css 3compartmentss Human 95% 5.729 mg/L 3.628 mg/L 1.57910694597574 -DTXSID6023159 Css 3compartmentss Human 95% 299.7 mg/L 167.4 mg/L 1.79032258064516 -DTXSID6023232 Css 3compartmentss Human 95% 4.814 mg/L 3.301 mg/L 1.45834595577098 -DTXSID6023280 Css 3compartmentss Human 95% 2.791 mg/L 1.804 mg/L 1.54711751662971 -DTXSID6023286 Css 3compartmentss Human 95% 0.0466 mg/L 0.0299 mg/L 1.55852842809365 -DTXSID6023313 Css 3compartmentss Human 95% 2.673 mg/L 1.636 mg/L 1.6338630806846 -DTXSID6023315 Css 3compartmentss Human 95% 5.537 mg/L 3.307 mg/L 1.6743271847596 -DTXSID6023317 Css 3compartmentss Human 95% 10.09 mg/L 2.119 mg/L 4.76168003775366 -DTXSID6023319 Css 3compartmentss Human 95% 6.058 mg/L 1.874 mg/L 3.23265741728922 -DTXSID6023363 Css 3compartmentss Human 95% 0.2705 mg/L 0.1326 mg/L 2.03996983408748 -DTXSID6023365 Css 3compartmentss Human 95% 0.1246 mg/L 0.0721 mg/L 1.72815533980583 -DTXSID6023367 Css 3compartmentss Human 95% 2.247 mg/L 1.323 mg/L 1.6984126984127 -DTXSID6023369 Css 3compartmentss Human 95% 5.671 mg/L 3.566 mg/L 1.59029725182277 -DTXSID6023440 Css 3compartmentss Human 95% 9.34 mg/L 5.893 mg/L 1.58493127439335 -DTXSID6023442 Css 3compartmentss Human 95% 3.547 mg/L 2.193 mg/L 1.61741906064751 -DTXSID6023490 Css 3compartmentss Human 95% 10.44 mg/L 2.25 mg/L 4.64 -DTXSID6023492 Css 3compartmentss Human 95% 64.09 mg/L 37.47 mg/L 1.71043501467841 -DTXSID6023496 Css 3compartmentss Human 95% 0.5101 mg/L 0.4231 mg/L 1.20562514771922 -DTXSID6023498 Css 3compartmentss Human 95% 1.231 mg/L 0.71 mg/L 1.73380281690141 -DTXSID6023523 Css 3compartmentss Human 95% 2.59 mg/L 0.816 mg/L 3.17401960784314 -DTXSID6023525 Css 3compartmentss Human 95% 0.4662 mg/L 0.1524 mg/L 3.05905511811024 -DTXSID6023529 Css 3compartmentss Human 95% 2.927 mg/L 1.753 mg/L 1.66970907016543 -DTXSID6023571 Css 3compartmentss Human 95% 0.9974 mg/L 0.3051 mg/L 3.26909210095051 -DTXSID6023573 Css 3compartmentss Human 95% 0.4202 mg/L 0.416 mg/L 1.01009615384615 -DTXSID6023579 Css 3compartmentss Human 95% 6.62 mg/L 3.196 mg/L 2.07133917396746 -DTXSID6023600 Css 3compartmentss Human 95% 1.702 mg/L 1.262 mg/L 1.3486529318542 -DTXSID6023602 Css 3compartmentss Human 95% 8.723 mg/L 5.504 mg/L 1.58484738372093 -DTXSID6023606 Css 3compartmentss Human 95% 5.32 mg/L 3.035 mg/L 1.75288303130148 -DTXSID6023608 Css 3compartmentss Human 95% 4.634 mg/L 2.541 mg/L 1.8236914600551 -DTXSID6023650 Css 3compartmentss Human 95% 0.09629 mg/L 0.06317 mg/L 1.52429950926072 -DTXSID6023652 Css 3compartmentss Human 95% 0.613 mg/L 0.4254 mg/L 1.44099670897978 -DTXSID6023656 Css 3compartmentss Human 95% 450.2 mg/L 0.3395 mg/L 1326.0677466863 -DTXSID6023658 Css 3compartmentss Human 95% 2.041 mg/L 0.6213 mg/L 3.28504748108804 -DTXSID6023733 Css 3compartmentss Human 95% 6.33 mg/L 4.096 mg/L 1.54541015625 -DTXSID6023735 Css 3compartmentss Human 95% 12.33 mg/L 6.716 mg/L 1.83591423466349 -DTXSID6023737 Css 3compartmentss Human 95% 0.144 mg/L 0.1023 mg/L 1.40762463343108 -DTXSID6023810 Css 3compartmentss Human 95% 2.258 mg/L 0.002388 mg/L 945.561139028476 -DTXSID6023862 Css 3compartmentss Human 95% 2.432 mg/L 1.681 mg/L 1.44675788221297 -DTXSID6023864 Css 3compartmentss Human 95% 15.23 mg/L 8.626 mg/L 1.76559239508463 -DTXSID6023868 Css 3compartmentss Human 95% 2670 mg/L 1400 mg/L 1.90714285714286 -DTXSID6023997 Css 3compartmentss Human 95% 2.766 mg/L 8.228e-06 mg/L 336169.178415168 -DTXSID6023999 Css 3compartmentss Human 95% 4.791 mg/L 2.4 mg/L 1.99625 -DTXSID6024046 Css 3compartmentss Human 95% 4.34 mg/L 2.978 mg/L 1.45735392881128 -DTXSID6024123 Css 3compartmentss Human 95% 0.6779 mg/L 0.1792 mg/L 3.78292410714286 -DTXSID6024175 Css 3compartmentss Human 95% 7.007 mg/L 5.705 mg/L 1.22822085889571 -DTXSID6024200 Css 3compartmentss Human 95% 0.7526 mg/L 0.4711 mg/L 1.59753767777542 -DTXSID6024204 Css 3compartmentss Human 95% 3.156 mg/L 2.014 mg/L 1.56703078450844 -DTXSID6024206 Css 3compartmentss Human 95% 67.24 mg/L 73.72 mg/L 0.912099837221921 -DTXSID6024331 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID6024337 Css 3compartmentss Human 95% 52.86 mg/L 19.75 mg/L 2.67645569620253 -DTXSID6024412 Css 3compartmentss Human 95% 2.122 mg/L 1.368 mg/L 1.55116959064327 -DTXSID6024414 Css 3compartmentss Human 95% 2.465 mg/L 1.666 mg/L 1.47959183673469 -DTXSID6024460 Css 3compartmentss Human 95% 20.52 mg/L 6.787 mg/L 3.02342714012082 -DTXSID6024462 Css 3compartmentss Human 95% 8.024 mg/L 4.922 mg/L 1.63023161316538 -DTXSID6024466 Css 3compartmentss Human 95% 2.544 mg/L 1.818 mg/L 1.3993399339934 -DTXSID6024591 Css 3compartmentss Human 95% 1.047 mg/L 0.6332 mg/L 1.65350600126342 -DTXSID6024597 Css 3compartmentss Human 95% 9.189 mg/L 4.523 mg/L 2.03161618394871 -DTXSID6024622 Css 3compartmentss Human 95% 3.245 mg/L 2.26 mg/L 1.4358407079646 -DTXSID6024624 Css 3compartmentss Human 95% 10.88 mg/L 4.555 mg/L 2.38858397365532 -DTXSID6024628 Css 3compartmentss Human 95% 5.712 mg/L 3.628 mg/L 1.57442116868798 -DTXSID6024670 Css 3compartmentss Human 95% 5.438 mg/L 3.527 mg/L 1.54182024383329 -DTXSID6024674 Css 3compartmentss Human 95% 0.1022 mg/L 0.0704 mg/L 1.45170454545455 -DTXSID6024701 Css 3compartmentss Human 95% 2.22 mg/L 0.003639 mg/L 610.057708161583 -DTXSID6024832 Css 3compartmentss Human 95% 47.92 mg/L 25.93 mg/L 1.84805244890089 -DTXSID6024838 Css 3compartmentss Human 95% 2.918 mg/L 0.2568 mg/L 11.3629283489097 -DTXSID6024882 Css 3compartmentss Human 95% 2.453 mg/L 1.42 mg/L 1.72746478873239 -DTXSID6024888 Css 3compartmentss Human 95% 2.626 mg/L 1.933 mg/L 1.3585100879462 -DTXSID6024917 Css 3compartmentss Human 95% 3.076 mg/L 3.801 mg/L 0.809260720862931 -DTXSID6024961 Css 3compartmentss Human 95% 2.888e-05 mg/L 0 mg/L Inf -DTXSID6024967 Css 3compartmentss Human 95% 9.492 mg/L 10.25 mg/L 0.926048780487805 -DTXSID6025010 Css 3compartmentss Human 95% 6.115 mg/L 4.224 mg/L 1.44767992424242 -DTXSID6025018 Css 3compartmentss Human 95% 0.3776 mg/L 0.1114 mg/L 3.38958707360862 -DTXSID6025064 Css 3compartmentss Human 95% 0.9393 mg/L 0.7108 mg/L 1.32146876758582 -DTXSID6025141 Css 3compartmentss Human 95% 5.569 mg/L 2.139 mg/L 2.60355306217859 -DTXSID6025143 Css 3compartmentss Human 95% 0.3458 mg/L 0.2978 mg/L 1.16118200134318 -DTXSID6025145 Css 3compartmentss Human 95% 0.3791 mg/L 0.3052 mg/L 1.24213630406291 -DTXSID6025149 Css 3compartmentss Human 95% 0.2927 mg/L 0.1899 mg/L 1.54133754607688 -DTXSID6025226 Css 3compartmentss Human 95% 59.76 mg/L 16.44 mg/L 3.63503649635036 -DTXSID6025272 Css 3compartmentss Human 95% 0.9242 mg/L 0.8024 mg/L 1.15179461615155 -DTXSID6025278 Css 3compartmentss Human 95% 0.3853 mg/L 0.2863 mg/L 1.34579112818722 -DTXSID6025305 Css 3compartmentss Human 95% 5.38 mg/L 3.537 mg/L 1.52106304778061 -DTXSID6025307 Css 3compartmentss Human 95% 3.153 mg/L 2.881e-06 mg/L 1094411.66261715 -DTXSID6025355 Css 3compartmentss Human 95% 0.7756 mg/L 0.494 mg/L 1.57004048582996 -DTXSID6025432 Css 3compartmentss Human 95% 6.151 mg/L 3.996 mg/L 1.53928928928929 -DTXSID6025436 Css 3compartmentss Human 95% 1.631 mg/L 1.017 mg/L 1.60373647984267 -DTXSID6025438 Css 3compartmentss Human 95% 933 mg/L 544.4 mg/L 1.71381337252021 -DTXSID6025486 Css 3compartmentss Human 95% 3.523 mg/L 2.856 mg/L 1.23354341736695 -DTXSID6025513 Css 3compartmentss Human 95% 0.3761 mg/L 0.00862 mg/L 43.631090487239 -DTXSID6025565 Css 3compartmentss Human 95% 0.6917 mg/L 0.4855 mg/L 1.42471678681771 -DTXSID6025567 Css 3compartmentss Human 95% 0.05779 mg/L 0.0348 mg/L 1.66063218390805 -DTXSID6025569 Css 3compartmentss Human 95% 3.077 mg/L 2.036 mg/L 1.51129666011788 -DTXSID6025640 Css 3compartmentss Human 95% 13.13 mg/L 7.586 mg/L 1.73081993145268 -DTXSID6025642 Css 3compartmentss Human 95% 14.05 mg/L 8.054 mg/L 1.74447479513285 -DTXSID6025690 Css 3compartmentss Human 95% 5.942 mg/L 2.556 mg/L 2.32472613458529 -DTXSID6025696 Css 3compartmentss Human 95% 2.479 mg/L 1.548 mg/L 1.60142118863049 -DTXSID6025723 Css 3compartmentss Human 95% 2.704 mg/L 1.685 mg/L 1.60474777448071 -DTXSID6025725 Css 3compartmentss Human 95% 1.664 mg/L 0.9754 mg/L 1.70596678285831 -DTXSID6025775 Css 3compartmentss Human 95% 8.928 mg/L 5.331 mg/L 1.6747326955543 -DTXSID6025850 Css 3compartmentss Human 95% 4.866 mg/L 3.53 mg/L 1.37847025495751 -DTXSID6025939 Css 3compartmentss Human 95% 4.525 mg/L 2.267 mg/L 1.99602999558888 -DTXSID6025983 Css 3compartmentss Human 95% 3.883 mg/L 2.495 mg/L 1.5563126252505 -DTXSID6026080 Css 3compartmentss Human 95% 23.67 mg/L 14.35 mg/L 1.64947735191638 -DTXSID6026115 Css 3compartmentss Human 95% 0.3119 mg/L 0.3165 mg/L 0.985466034755134 -DTXSID6026161 Css 3compartmentss Human 95% 27.88 mg/L 16.51 mg/L 1.68867353119322 -DTXSID6026292 Css 3compartmentss Human 95% 7.302 mg/L 7.439 mg/L 0.981583546175561 -DTXSID6026294 Css 3compartmentss Human 95% 0.06558 mg/L 0 mg/L Inf -DTXSID6026325 Css 3compartmentss Human 95% 0.6909 mg/L 0.4393 mg/L 1.57272934213521 -DTXSID6026373 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID6026450 Css 3compartmentss Human 95% 0.2991 mg/L 0.1589 mg/L 1.8823159219635 -DTXSID6026535 Css 3compartmentss Human 95% 8.639 mg/L 4.9 mg/L 1.7630612244898 -DTXSID6026537 Css 3compartmentss Human 95% 6.477 mg/L 3.964 mg/L 1.63395560040363 -DTXSID6026799 Css 3compartmentss Human 95% 6.029 mg/L 3.874 mg/L 1.55627258647393 -DTXSID6026878 Css 3compartmentss Human 95% 0.8473 mg/L 0.4256 mg/L 1.99083646616541 -DTXSID6026901 Css 3compartmentss Human 95% 0.1503 mg/L 0.002454 mg/L 61.2469437652812 -DTXSID6026955 Css 3compartmentss Human 95% 6.802 mg/L 4.139 mg/L 1.64339212370138 -DTXSID6027050 Css 3compartmentss Human 95% 7.282 mg/L 4.559 mg/L 1.59728010528625 -DTXSID6027052 Css 3compartmentss Human 95% 1498 mg/L 3023 mg/L 0.495534237512405 -DTXSID6027131 Css 3compartmentss Human 95% 2.342 mg/L 1.348 mg/L 1.73738872403561 -DTXSID6027133 Css 3compartmentss Human 95% 0.5852 mg/L 0.3543 mg/L 1.65170759243579 -DTXSID6027137 Css 3compartmentss Human 95% 3788 mg/L 9739 mg/L 0.388951637745148 -DTXSID6027214 Css 3compartmentss Human 95% 7.701 mg/L 4.79 mg/L 1.60772442588726 -DTXSID6027218 Css 3compartmentss Human 95% 3.454 mg/L 1.952 mg/L 1.76946721311475 -DTXSID6027262 Css 3compartmentss Human 95% 1.233 mg/L 0.5508 mg/L 2.23856209150327 -DTXSID6027341 Css 3compartmentss Human 95% 2.101 mg/L 1.412 mg/L 1.48796033994334 -DTXSID6027345 Css 3compartmentss Human 95% 16.21 mg/L 1.477 mg/L 10.9749492213947 -DTXSID6027395 Css 3compartmentss Human 95% 46.77 mg/L 45.13 mg/L 1.03633946377133 -DTXSID6027397 Css 3compartmentss Human 95% 1013 mg/L 2129 mg/L 0.475810239549084 -DTXSID6027503 Css 3compartmentss Human 95% 0.971 mg/L 0.6583 mg/L 1.47501139298192 -DTXSID6027507 Css 3compartmentss Human 95% 0.2322 mg/L 0.1952 mg/L 1.18954918032787 -DTXSID6027509 Css 3compartmentss Human 95% 5.697 mg/L 3.725 mg/L 1.52939597315436 -DTXSID6027551 Css 3compartmentss Human 95% 7.621 mg/L 4.548 mg/L 1.67568161829376 -DTXSID6027713 Css 3compartmentss Human 95% 8395 mg/L 9739 mg/L 0.861998151760961 -DTXSID6027921 Css 3compartmentss Human 95% 0.6651 mg/L 0.1417 mg/L 4.69371912491179 -DTXSID6027923 Css 3compartmentss Human 95% 32.01 mg/L 11.79 mg/L 2.71501272264631 -DTXSID6027925 Css 3compartmentss Human 95% 4.959 mg/L 0.1354 mg/L 36.6248153618907 -DTXSID6027975 Css 3compartmentss Human 95% 0.07704 mg/L 0 mg/L Inf -DTXSID6028028 Css 3compartmentss Human 95% 1.662 mg/L 0.9193 mg/L 1.80789731317307 -DTXSID6028492 Css 3compartmentss Human 95% 0.1001 mg/L 0.07062 mg/L 1.41744548286604 -DTXSID6029121 Css 3compartmentss Human 95% 8.089 mg/L 0.002699 mg/L 2997.03593923675 -DTXSID6029127 Css 3compartmentss Human 95% 3.361 mg/L 2.294 mg/L 1.46512641673932 -DTXSID6029202 Css 3compartmentss Human 95% 0.09138 mg/L 0.04479 mg/L 2.04018754186202 -DTXSID6029254 Css 3compartmentss Human 95% 15.2 mg/L 8.609 mg/L 1.76559414566152 -DTXSID6029335 Css 3compartmentss Human 95% 1324 mg/L 2812 mg/L 0.470839260312945 -DTXSID6029626 Css 3compartmentss Human 95% 11.04 mg/L 6.802 mg/L 1.62305204351661 -DTXSID6029670 Css 3compartmentss Human 95% 0.4554 mg/L 0.1545 mg/L 2.94757281553398 -DTXSID6029703 Css 3compartmentss Human 95% 7.56 mg/L 4.729 mg/L 1.59864664834003 -DTXSID6029707 Css 3compartmentss Human 95% 6.299 mg/L 4.171 mg/L 1.51018940302086 -DTXSID6029755 Css 3compartmentss Human 95% 7.131 mg/L 4.998 mg/L 1.42677070828331 -DTXSID6031209 Css 3compartmentss Human 95% 5.74 mg/L 3.703 mg/L 1.55009451795841 -DTXSID6031380 Css 3compartmentss Human 95% 2.119 mg/L 1.215 mg/L 1.7440329218107 -DTXSID6032061 Css 3compartmentss Human 95% 7.815 mg/L 4.885 mg/L 1.59979529170931 -DTXSID6032192 Css 3compartmentss Human 95% 5.454 mg/L 0.08535 mg/L 63.9015817223199 -DTXSID6032352 Css 3compartmentss Human 95% 12.92 mg/L 6.233 mg/L 2.07283811968554 -DTXSID6032354 Css 3compartmentss Human 95% 0.2734 mg/L 0.1548 mg/L 1.76614987080103 -DTXSID6032356 Css 3compartmentss Human 95% 3.022 mg/L 1.466 mg/L 2.06139154160982 -DTXSID6032358 Css 3compartmentss Human 95% 0.408 mg/L 0.2797 mg/L 1.45870575616732 -DTXSID6032431 Css 3compartmentss Human 95% 5.979 mg/L 3.299 mg/L 1.81236738405577 -DTXSID6032437 Css 3compartmentss Human 95% 28.59 mg/L 15.04 mg/L 1.90093085106383 -DTXSID6032514 Css 3compartmentss Human 95% 1.09 mg/L 0.7301 mg/L 1.49294617175729 -DTXSID6032516 Css 3compartmentss Human 95% 1.591 mg/L 0.9746 mg/L 1.63246460086189 -DTXSID6032562 Css 3compartmentss Human 95% 113.1 mg/L 211.9 mg/L 0.533742331288343 -DTXSID6032641 Css 3compartmentss Human 95% 242 mg/L 139.9 mg/L 1.72980700500357 -DTXSID6032645 Css 3compartmentss Human 95% 0.6994 mg/L 0.5442 mg/L 1.28518926865123 -DTXSID6032647 Css 3compartmentss Human 95% 0.8044 mg/L 0.4009 mg/L 2.00648540783238 -DTXSID6032649 Css 3compartmentss Human 95% 7.201 mg/L 0.5627 mg/L 12.7972276523903 -DTXSID6032722 Css 3compartmentss Human 95% 2.342 mg/L 1.348 mg/L 1.73738872403561 -DTXSID6033247 Css 3compartmentss Human 95% 2.299 mg/L 1.673 mg/L 1.3741781231321 -DTXSID6033326 Css 3compartmentss Human 95% 15.36 mg/L 0.05671 mg/L 270.851701639922 -DTXSID6033401 Css 3compartmentss Human 95% 13.87 mg/L 7.592 mg/L 1.82692307692308 -DTXSID6033538 Css 3compartmentss Human 95% 13.42 mg/L 9.122 mg/L 1.47116860337645 -DTXSID6033825 Css 3compartmentss Human 95% 0.6154 mg/L 0.4376 mg/L 1.4063071297989 -DTXSID6034005 Css 3compartmentss Human 95% 8.572 mg/L 5.31 mg/L 1.61431261770245 -DTXSID6034186 Css 3compartmentss Human 95% 1.964 mg/L 1.03 mg/L 1.90679611650485 -DTXSID6034265 Css 3compartmentss Human 95% 4.258 mg/L 3.006 mg/L 1.416500332668 -DTXSID6034392 Css 3compartmentss Human 95% 10.12 mg/L 4.486 mg/L 2.25590726705305 -DTXSID6034762 Css 3compartmentss Human 95% 118.2 mg/L 97.67 mg/L 1.21019760417733 -DTXSID6034764 Css 3compartmentss Human 95% 6.059 mg/L 3.248 mg/L 1.86545566502463 -DTXSID6034849 Css 3compartmentss Human 95% 0.8238 mg/L 0.4827 mg/L 1.70665009322561 -DTXSID6034924 Css 3compartmentss Human 95% 10.35 mg/L 6.6 mg/L 1.56818181818182 -DTXSID6034928 Css 3compartmentss Human 95% 9.542 mg/L 3.066 mg/L 3.11219830397913 -DTXSID6034972 Css 3compartmentss Human 95% 3.26 mg/L 2.178 mg/L 1.49678604224059 -DTXSID6035106 Css 3compartmentss Human 95% 5.581 mg/L 3.628 mg/L 1.53831312017641 -DTXSID6035784 Css 3compartmentss Human 95% 7.682 mg/L 0.0004247 mg/L 18088.0621615258 -DTXSID6036467 Css 3compartmentss Human 95% 9.529 mg/L 4.293 mg/L 2.21965991148381 -DTXSID6037015 Css 3compartmentss Human 95% 11530 mg/L 9647 mg/L 1.19519021457448 -DTXSID6037069 Css 3compartmentss Human 95% 37.6 mg/L 22.2 mg/L 1.69369369369369 -DTXSID6037483 Css 3compartmentss Human 95% 1.504 mg/L 0.866 mg/L 1.73672055427252 -DTXSID6037564 Css 3compartmentss Human 95% 9.748 mg/L 3.104 mg/L 3.14046391752577 -DTXSID6037568 Css 3compartmentss Human 95% 23.57 mg/L 13.64 mg/L 1.72800586510264 -DTXSID6037649 Css 3compartmentss Human 95% 8.97 mg/L 5.371 mg/L 1.67008005957922 -DTXSID6037697 Css 3compartmentss Human 95% 1.534 mg/L 0.9537 mg/L 1.60847226591171 -DTXSID6037728 Css 3compartmentss Human 95% 1.901 mg/L 0.9561 mg/L 1.98828574416902 -DTXSID6038827 Css 3compartmentss Human 95% 1.56 mg/L 1.051 mg/L 1.48430066603235 -DTXSID6038875 Css 3compartmentss Human 95% 1.62 mg/L 0.9498 mg/L 1.70562223626027 -DTXSID6038877 Css 3compartmentss Human 95% 6.368 mg/L 1.491 mg/L 4.2709590878605 -DTXSID6040115 Css 3compartmentss Human 95% 8.738 mg/L 4.911 mg/L 1.77927102423132 -DTXSID6040246 Css 3compartmentss Human 95% 221.4 mg/L 113.9 mg/L 1.94381035996488 -DTXSID6040290 Css 3compartmentss Human 95% 0.8497 mg/L 0.4637 mg/L 1.83243476385594 -DTXSID6040296 Css 3compartmentss Human 95% 118.6 mg/L 65.34 mg/L 1.81512090603 -DTXSID6040371 Css 3compartmentss Human 95% 12.85 mg/L 7.742 mg/L 1.65977783518471 -DTXSID6040373 Css 3compartmentss Human 95% 15.23 mg/L 0.001496 mg/L 10180.4812834225 -DTXSID6040375 Css 3compartmentss Human 95% 4.867 mg/L 3.208 mg/L 1.51714463840399 -DTXSID6040583 Css 3compartmentss Human 95% 3.625 mg/L 1.028 mg/L 3.52626459143969 -DTXSID6040614 Css 3compartmentss Human 95% 7.522 mg/L 4.721 mg/L 1.59330650285956 -DTXSID6040662 Css 3compartmentss Human 95% 14.61 mg/L 0.5453 mg/L 26.792591234183 -DTXSID6040664 Css 3compartmentss Human 95% 2.353 mg/L 1.868 mg/L 1.25963597430407 -DTXSID6040666 Css 3compartmentss Human 95% 2.838 mg/L 1.68 mg/L 1.68928571428571 -DTXSID6040668 Css 3compartmentss Human 95% 3.594 mg/L 1.71 mg/L 2.10175438596491 -DTXSID6040743 Css 3compartmentss Human 95% 77.59 mg/L 0.6405 mg/L 121.139734582358 -DTXSID6040745 Css 3compartmentss Human 95% 2.969 mg/L 1.483 mg/L 2.00202292650034 -DTXSID6040747 Css 3compartmentss Human 95% 5.779 mg/L 2.208 mg/L 2.61730072463768 -DTXSID6040795 Css 3compartmentss Human 95% 49.88 mg/L 27.52 mg/L 1.8125 -DTXSID6041056 Css 3compartmentss Human 95% 5.182 mg/L 3.403 mg/L 1.52277402292095 -DTXSID6041133 Css 3compartmentss Human 95% 28.06 mg/L 43.01 mg/L 0.6524064171123 -DTXSID6041347 Css 3compartmentss Human 95% 1.314 mg/L 0.3822 mg/L 3.43799058084772 -DTXSID6041349 Css 3compartmentss Human 95% 0.4286 mg/L 0.2484 mg/L 1.72544283413849 -DTXSID6041420 Css 3compartmentss Human 95% 7.983 mg/L 5.046 mg/L 1.5820451843044 -DTXSID6041422 Css 3compartmentss Human 95% 3.087 mg/L 1.617 mg/L 1.90909090909091 -DTXSID6041472 Css 3compartmentss Human 95% 0.6211 mg/L 0.4046 mg/L 1.53509639149778 -DTXSID6041503 Css 3compartmentss Human 95% 1664 mg/L 1368 mg/L 1.21637426900585 -DTXSID6041507 Css 3compartmentss Human 95% 0.5178 mg/L 0.4467 mg/L 1.15916722632639 -DTXSID6041551 Css 3compartmentss Human 95% 5.793 mg/L 2.028 mg/L 2.85650887573965 -DTXSID6041557 Css 3compartmentss Human 95% 2.915 mg/L 2.392 mg/L 1.21864548494983 -DTXSID6041638 Css 3compartmentss Human 95% 1.401 mg/L 0.9699 mg/L 1.44447881224869 -DTXSID6041682 Css 3compartmentss Human 95% 2363 mg/L 1389 mg/L 1.70122390208783 -DTXSID6041684 Css 3compartmentss Human 95% 8.431 mg/L 0.001348 mg/L 6254.45103857567 -DTXSID6041688 Css 3compartmentss Human 95% 5.958 mg/L 3.016 mg/L 1.97546419098143 -DTXSID6041715 Css 3compartmentss Human 95% 240.3 mg/L 138.7 mg/L 1.732516222062 -DTXSID6041719 Css 3compartmentss Human 95% 86.35 mg/L 46.58 mg/L 1.85379991412623 -DTXSID6041761 Css 3compartmentss Human 95% 0.03054 mg/L 0 mg/L Inf -DTXSID6041844 Css 3compartmentss Human 95% 5.576 mg/L 3.628 mg/L 1.53693495038589 -DTXSID6041892 Css 3compartmentss Human 95% 6.71 mg/L 4.027 mg/L 1.66625279364291 -DTXSID6041925 Css 3compartmentss Human 95% 0.5228 mg/L 0.3385 mg/L 1.54446085672083 -DTXSID6041927 Css 3compartmentss Human 95% 4.477 mg/L 2.663 mg/L 1.68118663161848 -DTXSID6041977 Css 3compartmentss Human 95% 23.58 mg/L 7.369 mg/L 3.19989143710137 -DTXSID6042072 Css 3compartmentss Human 95% 0.3588 mg/L 0.2077 mg/L 1.72749157438613 -DTXSID6042074 Css 3compartmentss Human 95% 3.984 mg/L 2.48 mg/L 1.60645161290323 -DTXSID6042151 Css 3compartmentss Human 95% 0.2216 mg/L 0.1999 mg/L 1.10855427713857 -DTXSID6042157 Css 3compartmentss Human 95% 3.711 mg/L 2.417 mg/L 1.53537443111295 -DTXSID6042232 Css 3compartmentss Human 95% 1.517 mg/L 1.439 mg/L 1.0542043085476 -DTXSID6042234 Css 3compartmentss Human 95% 8.909 mg/L 6.148 mg/L 1.44908913467794 -DTXSID6042280 Css 3compartmentss Human 95% 6.418 mg/L 2.136 mg/L 3.00468164794007 -DTXSID6042282 Css 3compartmentss Human 95% 2.551 mg/L 1.723 mg/L 1.4805571677307 -DTXSID6042315 Css 3compartmentss Human 95% 4.363 mg/L 2.634 mg/L 1.65641609719058 -DTXSID6042365 Css 3compartmentss Human 95% 6.532 mg/L 2.889 mg/L 2.26098996192454 -DTXSID6042369 Css 3compartmentss Human 95% 0.5125 mg/L 0.3522 mg/L 1.45513912549688 -DTXSID6042440 Css 3compartmentss Human 95% 40.63 mg/L 3.892 mg/L 10.4393627954779 -DTXSID6042448 Css 3compartmentss Human 95% 0.6936 mg/L 0.4739 mg/L 1.46359991559401 -DTXSID6042498 Css 3compartmentss Human 95% 0.07823 mg/L 0 mg/L Inf -DTXSID6042521 Css 3compartmentss Human 95% 3.429 mg/L 2.099 mg/L 1.63363506431634 -DTXSID6042579 Css 3compartmentss Human 95% 1.582 mg/L 0.9242 mg/L 1.71175070331097 -DTXSID6042602 Css 3compartmentss Human 95% 0.3789 mg/L 0.003486 mg/L 108.691910499139 -DTXSID6043709 Css 3compartmentss Human 95% 0.1263 mg/L 0.01042 mg/L 12.1209213051823 -DTXSID6043913 Css 3compartmentss Human 95% 0.3669 mg/L 0.2331 mg/L 1.57400257400257 -DTXSID6043915 Css 3compartmentss Human 95% 2.201 mg/L 0.1166 mg/L 18.8765008576329 -DTXSID6043917 Css 3compartmentss Human 95% 5.642 mg/L 3.628 mg/L 1.55512679162073 -DTXSID6043919 Css 3compartmentss Human 95% 5.575 mg/L 3.628 mg/L 1.53665931642778 -DTXSID6044012 Css 3compartmentss Human 95% 433.2 mg/L 719.4 mg/L 0.602168473728107 -DTXSID6044014 Css 3compartmentss Human 95% 1.673 mg/L 1.236 mg/L 1.35355987055016 -DTXSID6044199 Css 3compartmentss Human 95% 0.004682 mg/L 0 mg/L Inf -DTXSID6044226 Css 3compartmentss Human 95% 36.12 mg/L 16.25 mg/L 2.22276923076923 -DTXSID6044272 Css 3compartmentss Human 95% 35.77 mg/L 23.1 mg/L 1.54848484848485 -DTXSID6044303 Css 3compartmentss Human 95% 224.3 mg/L 0.0007369 mg/L 304383.227032162 -DTXSID6044307 Css 3compartmentss Human 95% 5.271 mg/L 5.511 mg/L 0.956450734893849 -DTXSID6044355 Css 3compartmentss Human 95% 0.5196 mg/L 0.4134 mg/L 1.25689404934688 -DTXSID6044357 Css 3compartmentss Human 95% 0.04844 mg/L 0.03428 mg/L 1.41306884480747 -DTXSID6044359 Css 3compartmentss Human 95% 23.96 mg/L 0.03131 mg/L 765.250718620249 -DTXSID6044430 Css 3compartmentss Human 95% 8.098 mg/L 5.543 mg/L 1.46094172830597 -DTXSID6044436 Css 3compartmentss Human 95% 8.46 mg/L 5.184 mg/L 1.63194444444444 -DTXSID6044438 Css 3compartmentss Human 95% 5.214 mg/L 3.461 mg/L 1.50650101126842 -DTXSID6044480 Css 3compartmentss Human 95% 2.167 mg/L 1.377 mg/L 1.57371096586783 -DTXSID6044484 Css 3compartmentss Human 95% 0.04741 mg/L 0.02457 mg/L 1.92958892958893 -DTXSID6044486 Css 3compartmentss Human 95% 0.5276 mg/L 0.3422 mg/L 1.54178842781999 -DTXSID6044488 Css 3compartmentss Human 95% 3.143 mg/L 2.412 mg/L 1.3030679933665 -DTXSID6044511 Css 3compartmentss Human 95% 5.65 mg/L 4.722 mg/L 1.19652689538331 -DTXSID6044513 Css 3compartmentss Human 95% 0.4767 mg/L 0.4245 mg/L 1.12296819787986 -DTXSID6044515 Css 3compartmentss Human 95% 2.065 mg/L 1.241 mg/L 1.66398066075745 -DTXSID6044517 Css 3compartmentss Human 95% 2.008 mg/L 1.283 mg/L 1.56508183943882 -DTXSID6044519 Css 3compartmentss Human 95% 64.35 mg/L 7.696 mg/L 8.36148648648649 -DTXSID6044561 Css 3compartmentss Human 95% 0.2287 mg/L 0.1652 mg/L 1.38438256658596 -DTXSID6044563 Css 3compartmentss Human 95% 1.418 mg/L 0.9324 mg/L 1.52080652080652 -DTXSID6044565 Css 3compartmentss Human 95% 0.1026 mg/L 0.07719 mg/L 1.3291877186164 -DTXSID6044642 Css 3compartmentss Human 95% 8.074 mg/L 4.446 mg/L 1.81601439496176 -DTXSID6044644 Css 3compartmentss Human 95% 0.6592 mg/L 0.4183 mg/L 1.5759024623476 -DTXSID6044646 Css 3compartmentss Human 95% 0.04836 mg/L 0.03181 mg/L 1.52027664256523 -DTXSID6044648 Css 3compartmentss Human 95% 0.8642 mg/L 0.3257 mg/L 2.65336198956095 -DTXSID6044690 Css 3compartmentss Human 95% 1.974 mg/L 0.4802 mg/L 4.11078717201166 -DTXSID6044692 Css 3compartmentss Human 95% 0.2997 mg/L 0.1838 mg/L 1.63057671381937 -DTXSID6044696 Css 3compartmentss Human 95% 0.07428 mg/L 0.04739 mg/L 1.56741928676936 -DTXSID6044721 Css 3compartmentss Human 95% 5.255 mg/L 3.711 mg/L 1.41606036108866 -DTXSID6044723 Css 3compartmentss Human 95% 6.609 mg/L 4.798 mg/L 1.37744893705711 -DTXSID6044725 Css 3compartmentss Human 95% 5.36 mg/L 3.636 mg/L 1.47414741474147 -DTXSID6044771 Css 3compartmentss Human 95% 6.883 mg/L 4.319 mg/L 1.59365593887474 -DTXSID6044773 Css 3compartmentss Human 95% 6.909 mg/L 5.695 mg/L 1.21316944688323 -DTXSID6044777 Css 3compartmentss Human 95% 0.2835 mg/L 0.1788 mg/L 1.58557046979866 -DTXSID6044779 Css 3compartmentss Human 95% 2.859 mg/L 1.695 mg/L 1.68672566371681 -DTXSID6044800 Css 3compartmentss Human 95% 4.098 mg/L 2.546 mg/L 1.60958366064415 -DTXSID6044802 Css 3compartmentss Human 95% 4.199 mg/L 1.292 mg/L 3.25 -DTXSID6044804 Css 3compartmentss Human 95% 5.565 mg/L 2.139 mg/L 2.60168302945302 -DTXSID6044854 Css 3compartmentss Human 95% 3.204 mg/L 3.997 mg/L 0.801601200900676 -DTXSID6044856 Css 3compartmentss Human 95% 0.9557 mg/L 0.3943 mg/L 2.42378899315242 -DTXSID6044858 Css 3compartmentss Human 95% 25.75 mg/L 15.22 mg/L 1.69185282522996 -DTXSID6044931 Css 3compartmentss Human 95% 0.1956 mg/L 0.1451 mg/L 1.34803583735355 -DTXSID6044933 Css 3compartmentss Human 95% 3.715 mg/L 2.315 mg/L 1.60475161987041 -DTXSID6044935 Css 3compartmentss Human 95% 1.315 mg/L 0.8634 mg/L 1.52304841324994 -DTXSID6044981 Css 3compartmentss Human 95% 8.027 mg/L 4.878 mg/L 1.64555145551455 -DTXSID6044983 Css 3compartmentss Human 95% 8.726 mg/L 5.77 mg/L 1.51230502599653 -DTXSID6044985 Css 3compartmentss Human 95% 5.006 mg/L 3.96 mg/L 1.26414141414141 -DTXSID6044989 Css 3compartmentss Human 95% 2.065 mg/L 1.834 mg/L 1.12595419847328 -DTXSID6045082 Css 3compartmentss Human 95% 1.38 mg/L 0.7847 mg/L 1.75863387281764 -DTXSID6045084 Css 3compartmentss Human 95% 8.928 mg/L 5.614 mg/L 1.59030993943712 -DTXSID6045086 Css 3compartmentss Human 95% 76.55 mg/L 55.04 mg/L 1.39080668604651 -DTXSID6045088 Css 3compartmentss Human 95% 4.996 mg/L 3.543 mg/L 1.41010443127293 -DTXSID6045111 Css 3compartmentss Human 95% 2.909 mg/L 1.739 mg/L 1.6728004600345 -DTXSID6045115 Css 3compartmentss Human 95% 19.59 mg/L 10.77 mg/L 1.81894150417827 -DTXSID6045117 Css 3compartmentss Human 95% 6.978 mg/L 3.317 mg/L 2.10370817003316 -DTXSID6045119 Css 3compartmentss Human 95% 10.75 mg/L 7.268 mg/L 1.47908640616401 -DTXSID6045161 Css 3compartmentss Human 95% 0.1113 mg/L 0.07728 mg/L 1.44021739130435 -DTXSID6045163 Css 3compartmentss Human 95% 5.896 mg/L 0.4535 mg/L 13.0011025358324 -DTXSID6045165 Css 3compartmentss Human 95% 10.59 mg/L 0.2852 mg/L 37.1318373071529 -DTXSID6045167 Css 3compartmentss Human 95% 3.205 mg/L 1.673 mg/L 1.9157202630006 -DTXSID6045169 Css 3compartmentss Human 95% 1.635 mg/L 0.9144 mg/L 1.78805774278215 -DTXSID6045240 Css 3compartmentss Human 95% 4.467 mg/L 2.286e-05 mg/L 195406.824146982 -DTXSID6045244 Css 3compartmentss Human 95% 2.464 mg/L 1.452 mg/L 1.6969696969697 -DTXSID6045248 Css 3compartmentss Human 95% 0.1259 mg/L 0.06345 mg/L 1.98423955870764 -DTXSID6045292 Css 3compartmentss Human 95% 1.772 mg/L 0.7336 mg/L 2.4154852780807 -DTXSID6045296 Css 3compartmentss Human 95% 0.3854 mg/L 0.2892 mg/L 1.33264177040111 -DTXSID6045321 Css 3compartmentss Human 95% 0.1496 mg/L 0.1295 mg/L 1.15521235521236 -DTXSID6045323 Css 3compartmentss Human 95% 2.693 mg/L 1.408 mg/L 1.91264204545455 -DTXSID6045325 Css 3compartmentss Human 95% 0.2064 mg/L 0.1412 mg/L 1.46175637393768 -DTXSID6045371 Css 3compartmentss Human 95% 1.8 mg/L 0.9646 mg/L 1.86605846983205 -DTXSID6045373 Css 3compartmentss Human 95% 3.298 mg/L 1.018 mg/L 3.23968565815324 -DTXSID6045375 Css 3compartmentss Human 95% 3.244 mg/L 1.595 mg/L 2.03385579937304 -DTXSID6045377 Css 3compartmentss Human 95% 6.561 mg/L 0.02001 mg/L 327.886056971514 -DTXSID6045400 Css 3compartmentss Human 95% 1.21 mg/L 1.197 mg/L 1.01086048454469 -DTXSID6045402 Css 3compartmentss Human 95% 0.02008 mg/L 0.00974 mg/L 2.06160164271047 -DTXSID6045452 Css 3compartmentss Human 95% 22.29 mg/L 1.837 mg/L 12.1339139902014 -DTXSID6045531 Css 3compartmentss Human 95% 0.4091 mg/L 0.2752 mg/L 1.48655523255814 -DTXSID6045533 Css 3compartmentss Human 95% 3.811 mg/L 1.563 mg/L 2.4382597568778 -DTXSID6045535 Css 3compartmentss Human 95% 21.06 mg/L 11.38 mg/L 1.8506151142355 -DTXSID6045537 Css 3compartmentss Human 95% 0.4334 mg/L 0.2729 mg/L 1.58812751923782 -DTXSID6045539 Css 3compartmentss Human 95% 1.73 mg/L 1.273 mg/L 1.35899450117832 -DTXSID6045581 Css 3compartmentss Human 95% 4.76 mg/L 2.812 mg/L 1.6927453769559 -DTXSID6045583 Css 3compartmentss Human 95% 55.57 mg/L 42.66 mg/L 1.30262541022035 -DTXSID6045585 Css 3compartmentss Human 95% 8.116 mg/L 5.084 mg/L 1.5963808025177 -DTXSID6045614 Css 3compartmentss Human 95% 1.774 mg/L 0.9601 mg/L 1.84772419539631 -DTXSID6045616 Css 3compartmentss Human 95% 1.927 mg/L 0.003423 mg/L 562.956470931931 -DTXSID6045618 Css 3compartmentss Human 95% 5.925 mg/L 4.08 mg/L 1.45220588235294 -DTXSID6045660 Css 3compartmentss Human 95% 1.557 mg/L 1.286 mg/L 1.21073094867807 -DTXSID6045662 Css 3compartmentss Human 95% 1.367 mg/L 0.3084 mg/L 4.4325551232166 -DTXSID6045666 Css 3compartmentss Human 95% 0.2662 mg/L 0.1761 mg/L 1.51164111300397 -DTXSID6045668 Css 3compartmentss Human 95% 3.116 mg/L 1.67 mg/L 1.86586826347305 -DTXSID6045741 Css 3compartmentss Human 95% 53 mg/L 35.23 mg/L 1.50439965938121 -DTXSID6045743 Css 3compartmentss Human 95% 8.136 mg/L 5.127 mg/L 1.58689291983616 -DTXSID6045745 Css 3compartmentss Human 95% 1.607 mg/L 1.058 mg/L 1.51890359168242 -DTXSID6045749 Css 3compartmentss Human 95% 0.5586 mg/L 0.4057 mg/L 1.37687946758689 -DTXSID6045791 Css 3compartmentss Human 95% 2.423 mg/L 0.1876 mg/L 12.9157782515991 -DTXSID6045795 Css 3compartmentss Human 95% 1.729 mg/L 1.078 mg/L 1.6038961038961 -DTXSID6045820 Css 3compartmentss Human 95% 16.24 mg/L 10.38 mg/L 1.5645472061657 -DTXSID6045828 Css 3compartmentss Human 95% 0.2709 mg/L 0.2 mg/L 1.3545 -DTXSID6045870 Css 3compartmentss Human 95% 3.64 mg/L 2.136 mg/L 1.70411985018727 -DTXSID6045872 Css 3compartmentss Human 95% 12.96 mg/L 7.657 mg/L 1.69256889121066 -DTXSID6045874 Css 3compartmentss Human 95% 12.53 mg/L 7.598 mg/L 1.6491181889971 -DTXSID6045878 Css 3compartmentss Human 95% 58.35 mg/L 33.5 mg/L 1.74179104477612 -DTXSID6045901 Css 3compartmentss Human 95% 0.6847 mg/L 0.4186 mg/L 1.63569039655996 -DTXSID6045903 Css 3compartmentss Human 95% 2.438 mg/L 1.176 mg/L 2.07312925170068 -DTXSID6045905 Css 3compartmentss Human 95% 1.618 mg/L 0.8125 mg/L 1.99138461538462 -DTXSID6045907 Css 3compartmentss Human 95% 22.3 mg/L 13.71 mg/L 1.62654996353027 -DTXSID6045909 Css 3compartmentss Human 95% 0.6262 mg/L 0.4156 mg/L 1.50673724735322 -DTXSID6045951 Css 3compartmentss Human 95% 1.941 mg/L 1.831 mg/L 1.0600764609503 -DTXSID6045953 Css 3compartmentss Human 95% 1.695 mg/L 1.252 mg/L 1.3538338658147 -DTXSID6045955 Css 3compartmentss Human 95% 6.379 mg/L 2.886 mg/L 2.21032571032571 -DTXSID6045957 Css 3compartmentss Human 95% 2.132 mg/L 0.008468 mg/L 251.771374586679 -DTXSID6045959 Css 3compartmentss Human 95% 2159 mg/L 9739 mg/L 0.221686004723278 -DTXSID6046000 Css 3compartmentss Human 95% 0.2442 mg/L 0.0002748 mg/L 888.646288209607 -DTXSID6046008 Css 3compartmentss Human 95% 0.04044 mg/L 0.0134 mg/L 3.01791044776119 -DTXSID6046054 Css 3compartmentss Human 95% 0.03156 mg/L 2e-09 mg/L 15780000 -DTXSID6046131 Css 3compartmentss Human 95% 321.8 mg/L 173.2 mg/L 1.85796766743649 -DTXSID6046133 Css 3compartmentss Human 95% 97.4 mg/L 57.68 mg/L 1.68862690707351 -DTXSID6046135 Css 3compartmentss Human 95% 0.8764 mg/L 0.5569 mg/L 1.57371161788472 -DTXSID6046137 Css 3compartmentss Human 95% 0.889 mg/L 0.4032 mg/L 2.20486111111111 -DTXSID6046139 Css 3compartmentss Human 95% 0.05384 mg/L 0.03626 mg/L 1.48483177054606 -DTXSID6046181 Css 3compartmentss Human 95% 1.289 mg/L 0.821 mg/L 1.5700365408039 -DTXSID6046183 Css 3compartmentss Human 95% 10.19 mg/L 2.808 mg/L 3.62891737891738 -DTXSID6046185 Css 3compartmentss Human 95% 41.12 mg/L 22.7 mg/L 1.81145374449339 -DTXSID6046187 Css 3compartmentss Human 95% 4.126 mg/L 3.304 mg/L 1.24878934624697 -DTXSID6046189 Css 3compartmentss Human 95% 3.889 mg/L 2.518 mg/L 1.54447974583002 -DTXSID6046210 Css 3compartmentss Human 95% 2.049 mg/L 1.055 mg/L 1.94218009478673 -DTXSID6046212 Css 3compartmentss Human 95% 0.2209 mg/L 2e-09 mg/L 110450000 -DTXSID6046214 Css 3compartmentss Human 95% 5.263 mg/L 3.334 mg/L 1.57858428314337 -DTXSID6046216 Css 3compartmentss Human 95% 266.9 mg/L 145.4 mg/L 1.83562585969739 -DTXSID6046218 Css 3compartmentss Human 95% 4.757 mg/L 1.365 mg/L 3.48498168498168 -DTXSID6046260 Css 3compartmentss Human 95% 6.196 mg/L 2.657 mg/L 2.33195333082424 -DTXSID6046262 Css 3compartmentss Human 95% 7.646 mg/L 4.798 mg/L 1.59358065860775 -DTXSID6046264 Css 3compartmentss Human 95% 0.395 mg/L 0.25 mg/L 1.58 -DTXSID6046266 Css 3compartmentss Human 95% 1.422 mg/L 0.8067 mg/L 1.76273707698029 -DTXSID6046268 Css 3compartmentss Human 95% 1.628 mg/L 1.176 mg/L 1.3843537414966 -DTXSID6046341 Css 3compartmentss Human 95% 0.07179 mg/L 0.05055 mg/L 1.42017804154303 -DTXSID6046343 Css 3compartmentss Human 95% 1.087 mg/L 0.6553 mg/L 1.65878223714329 -DTXSID6046345 Css 3compartmentss Human 95% 5.586 mg/L 3.628 mg/L 1.53969128996692 -DTXSID6046347 Css 3compartmentss Human 95% 5.53 mg/L 2.503 mg/L 2.20934878146225 -DTXSID6046349 Css 3compartmentss Human 95% 5.32 mg/L 3.307 mg/L 1.60870879951618 -DTXSID6046391 Css 3compartmentss Human 95% 4.432 mg/L 2.743 mg/L 1.61574917973022 -DTXSID6046393 Css 3compartmentss Human 95% 6.022 mg/L 3.682 mg/L 1.63552417164584 -DTXSID6046395 Css 3compartmentss Human 95% 13.33 mg/L 7.26 mg/L 1.83608815426997 -DTXSID6046397 Css 3compartmentss Human 95% 7.951 mg/L 4.958 mg/L 1.60367083501412 -DTXSID6046399 Css 3compartmentss Human 95% 5.046 mg/L 3.065 mg/L 1.6463295269168 -DTXSID6046420 Css 3compartmentss Human 95% 0.4075 mg/L 0.3136 mg/L 1.29942602040816 -DTXSID6046422 Css 3compartmentss Human 95% 5.575 mg/L 3.733 mg/L 1.49343691401018 -DTXSID6046424 Css 3compartmentss Human 95% 0.9551 mg/L 0.9908 mg/L 0.963968510294711 -DTXSID6046426 Css 3compartmentss Human 95% 0.03806 mg/L 0.01544 mg/L 2.46502590673575 -DTXSID6046428 Css 3compartmentss Human 95% 5.716 mg/L 3.341 mg/L 1.71086501047591 -DTXSID6046470 Css 3compartmentss Human 95% 2.197 mg/L 0.3663 mg/L 5.997815997816 -DTXSID6046472 Css 3compartmentss Human 95% 0.2404 mg/L 9.574e-06 mg/L 25109.6720284103 -DTXSID6046474 Css 3compartmentss Human 95% 6.943 mg/L 3.802 mg/L 1.82614413466597 -DTXSID6046476 Css 3compartmentss Human 95% 10.28 mg/L 5.503 mg/L 1.86807196074868 -DTXSID6046478 Css 3compartmentss Human 95% 19.99 mg/L 8.641 mg/L 2.31338965397523 -DTXSID6046501 Css 3compartmentss Human 95% 45.76 mg/L 23.15 mg/L 1.97667386609071 -DTXSID6046503 Css 3compartmentss Human 95% 2.396 mg/L 0.4906 mg/L 4.88381573583367 -DTXSID6046505 Css 3compartmentss Human 95% 0.3286 mg/L 0.2099 mg/L 1.56550738446879 -DTXSID6046507 Css 3compartmentss Human 95% 3.055 mg/L 0.03131 mg/L 97.5726604918556 -DTXSID6046509 Css 3compartmentss Human 95% 11.8 mg/L 6.594 mg/L 1.78950561116166 -DTXSID6046551 Css 3compartmentss Human 95% 4.825 mg/L 3.101 mg/L 1.55594969364721 -DTXSID6046553 Css 3compartmentss Human 95% 2.293 mg/L 1.247e-06 mg/L 1838813.15156375 -DTXSID6046555 Css 3compartmentss Human 95% 3.25 mg/L 1.596 mg/L 2.03634085213033 -DTXSID6046557 Css 3compartmentss Human 95% 138 mg/L 77.65 mg/L 1.77720540888603 -DTXSID6046630 Css 3compartmentss Human 95% 218.7 mg/L 122.6 mg/L 1.78384991843393 -DTXSID6046634 Css 3compartmentss Human 95% 8.241 mg/L 4.705 mg/L 1.75154091392136 -DTXSID6046636 Css 3compartmentss Human 95% 95.17 mg/L 87.96 mg/L 1.08196907685312 -DTXSID6046638 Css 3compartmentss Human 95% 100.5 mg/L 44.74 mg/L 2.24631202503353 -DTXSID6046682 Css 3compartmentss Human 95% 0.3646 mg/L 0.003843 mg/L 94.8737965131408 -DTXSID6046686 Css 3compartmentss Human 95% 245.7 mg/L 133.4 mg/L 1.84182908545727 -DTXSID6046688 Css 3compartmentss Human 95% 7.525 mg/L 4.997 mg/L 1.50590354212528 -DTXSID6046713 Css 3compartmentss Human 95% 4.986 mg/L 3.289 mg/L 1.51596229857099 -DTXSID6046715 Css 3compartmentss Human 95% 2.227 mg/L 1.608 mg/L 1.38495024875622 -DTXSID6046719 Css 3compartmentss Human 95% 9.481 mg/L 8.337 mg/L 1.13721962336572 -DTXSID6046761 Css 3compartmentss Human 95% 1.095 mg/L 0.7286 mg/L 1.50288223991216 -DTXSID6046763 Css 3compartmentss Human 95% 11.93 mg/L 7.059 mg/L 1.69004108230628 -DTXSID6046765 Css 3compartmentss Human 95% 2.506 mg/L 1.564 mg/L 1.60230179028133 -DTXSID6046767 Css 3compartmentss Human 95% 0.6242 mg/L 0.369 mg/L 1.69159891598916 -DTXSID6046842 Css 3compartmentss Human 95% 5.981 mg/L 3.86 mg/L 1.54948186528497 -DTXSID6046844 Css 3compartmentss Human 95% 4.324 mg/L 0.0002213 mg/L 19539.0872119295 -DTXSID6046846 Css 3compartmentss Human 95% 0.5382 mg/L 0.2875 mg/L 1.872 -DTXSID6046890 Css 3compartmentss Human 95% 0.02127 mg/L 0.01246 mg/L 1.70706260032103 -DTXSID6046892 Css 3compartmentss Human 95% 0.1721 mg/L 0.1 mg/L 1.721 -DTXSID6046894 Css 3compartmentss Human 95% 29.71 mg/L 18.13 mg/L 1.63872035300607 -DTXSID6046896 Css 3compartmentss Human 95% 1.383 mg/L 0.7039 mg/L 1.96476772268788 -DTXSID6046898 Css 3compartmentss Human 95% 2.309 mg/L 1.134 mg/L 2.03615520282187 -DTXSID6046925 Css 3compartmentss Human 95% 4.531 mg/L 0.0373 mg/L 121.474530831099 -DTXSID6046977 Css 3compartmentss Human 95% 0.2544 mg/L 0.1823 mg/L 1.39550191991223 -DTXSID6046979 Css 3compartmentss Human 95% 24.33 mg/L 1.255 mg/L 19.3864541832669 -DTXSID6047028 Css 3compartmentss Human 95% 3.501 mg/L 2.4 mg/L 1.45875 -DTXSID6047070 Css 3compartmentss Human 95% 7.982 mg/L 4.956 mg/L 1.61057304277643 -DTXSID6047072 Css 3compartmentss Human 95% 2.718 mg/L 2.717 mg/L 1.00036805299963 -DTXSID6047076 Css 3compartmentss Human 95% 6.827 mg/L 9739 mg/L 0.000700995995482082 -DTXSID6047101 Css 3compartmentss Human 95% 3.864 mg/L 2.454 mg/L 1.57457212713936 -DTXSID6047103 Css 3compartmentss Human 95% 114.7 mg/L 3.743 mg/L 30.6438685546353 -DTXSID6047105 Css 3compartmentss Human 95% 0.7031 mg/L 0.4716 mg/L 1.49088210347752 -DTXSID6047155 Css 3compartmentss Human 95% 5.933 mg/L 3.798 mg/L 1.56213796735124 -DTXSID6047157 Css 3compartmentss Human 95% 11.41 mg/L 9.688 mg/L 1.17774566473988 -DTXSID6047280 Css 3compartmentss Human 95% 0.5762 mg/L 0.1342 mg/L 4.29359165424739 -DTXSID6047282 Css 3compartmentss Human 95% 75.08 mg/L 44.38 mg/L 1.69175304191077 -DTXSID6047284 Css 3compartmentss Human 95% 0.4358 mg/L 0.2895 mg/L 1.50535405872193 -DTXSID6047286 Css 3compartmentss Human 95% 3.075 mg/L 2.77 mg/L 1.1101083032491 -DTXSID6047288 Css 3compartmentss Human 95% 0.05503 mg/L 0 mg/L Inf -DTXSID6047311 Css 3compartmentss Human 95% 1.661 mg/L 1.8e-07 mg/L 9227777.77777778 -DTXSID6047313 Css 3compartmentss Human 95% 0.1577 mg/L 0.02249 mg/L 7.01200533570476 -DTXSID6047315 Css 3compartmentss Human 95% 32.02 mg/L 0.07676 mg/L 417.144346013549 -DTXSID6047319 Css 3compartmentss Human 95% 29.85 mg/L 20.01 mg/L 1.49175412293853 -DTXSID6047363 Css 3compartmentss Human 95% 0.571 mg/L 0.3903 mg/L 1.46297719702793 -DTXSID6047369 Css 3compartmentss Human 95% 33.88 mg/L 0.01546 mg/L 2191.46183699871 -DTXSID6047444 Css 3compartmentss Human 95% 3.625 mg/L 3.505 mg/L 1.03423680456491 -DTXSID6047446 Css 3compartmentss Human 95% 5.83 mg/L 4.375 mg/L 1.33257142857143 -DTXSID6047448 Css 3compartmentss Human 95% 8.505 mg/L 5.69 mg/L 1.49472759226714 -DTXSID6047498 Css 3compartmentss Human 95% 10820 mg/L 9739 mg/L 1.11099702228155 -DTXSID6047523 Css 3compartmentss Human 95% 7.255 mg/L 4.1 mg/L 1.76951219512195 -DTXSID6047525 Css 3compartmentss Human 95% 8.16 mg/L 5.623 mg/L 1.45118264271741 -DTXSID6047527 Css 3compartmentss Human 95% 13.82 mg/L 5.946 mg/L 2.32425159771275 -DTXSID6047529 Css 3compartmentss Human 95% 5.385 mg/L 3.387 mg/L 1.58990256864482 -DTXSID6047654 Css 3compartmentss Human 95% 89.72 mg/L 0.00127 mg/L 70645.6692913386 -DTXSID6047656 Css 3compartmentss Human 95% 10.9 mg/L 7.301 mg/L 1.49294617175729 -DTXSID6047781 Css 3compartmentss Human 95% 0.6339 mg/L 0.5322 mg/L 1.19109357384442 -DTXSID6047783 Css 3compartmentss Human 95% 29.36 mg/L 2.705 mg/L 10.8539741219963 -DTXSID6047785 Css 3compartmentss Human 95% 2.764 mg/L 0.3577 mg/L 7.72714565278166 -DTXSID6047787 Css 3compartmentss Human 95% 0.9702 mg/L 0.2775 mg/L 3.49621621621622 -DTXSID6047789 Css 3compartmentss Human 95% 1.793 mg/L 1.114 mg/L 1.60951526032316 -DTXSID6047810 Css 3compartmentss Human 95% 4.655 mg/L 2.72 mg/L 1.71139705882353 -DTXSID6047818 Css 3compartmentss Human 95% 2.632 mg/L 1.632 mg/L 1.61274509803922 -DTXSID6047947 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID6048171 Css 3compartmentss Human 95% 20.97 mg/L 0.0002391 mg/L 87703.8895859473 -DTXSID6048175 Css 3compartmentss Human 95% 12.9 mg/L 4.255 mg/L 3.03172737955347 -DTXSID6048200 Css 3compartmentss Human 95% 70.59 mg/L 41 mg/L 1.72170731707317 -DTXSID6048204 Css 3compartmentss Human 95% 14.98 mg/L 16.58 mg/L 0.903498190591074 -DTXSID6048208 Css 3compartmentss Human 95% 0.2156 mg/L 0.2007 mg/L 1.07424015944195 -DTXSID6048333 Css 3compartmentss Human 95% 23.96 mg/L 44.79 mg/L 0.534940835007814 -DTXSID6048383 Css 3compartmentss Human 95% 8.509 mg/L 6.492 mg/L 1.31069008009858 -DTXSID6048591 Css 3compartmentss Human 95% 7.534 mg/L 4.974 mg/L 1.51467631684761 -DTXSID6048593 Css 3compartmentss Human 95% 5.913 mg/L 3.773 mg/L 1.56718791412669 -DTXSID6048595 Css 3compartmentss Human 95% 0.1096 mg/L 0.07158 mg/L 1.53115395361833 -DTXSID6048597 Css 3compartmentss Human 95% 59.23 mg/L 35.68 mg/L 1.660033632287 -DTXSID6048599 Css 3compartmentss Human 95% 0.1018 mg/L 0.06488 mg/L 1.56905055487053 -DTXSID6048620 Css 3compartmentss Human 95% 0.4626 mg/L 0 mg/L Inf -DTXSID6048622 Css 3compartmentss Human 95% 53.18 mg/L 3.142 mg/L 16.9255251432209 -DTXSID6048624 Css 3compartmentss Human 95% 24.16 mg/L 14.11 mg/L 1.71226080793763 -DTXSID6048626 Css 3compartmentss Human 95% 43.97 mg/L 24.45 mg/L 1.79836400817996 -DTXSID6048628 Css 3compartmentss Human 95% 9.631 mg/L 3.942 mg/L 2.44317605276509 -DTXSID6048670 Css 3compartmentss Human 95% 192.5 mg/L 103.3 mg/L 1.86350435624395 -DTXSID6048672 Css 3compartmentss Human 95% 1.284 mg/L 0.8456 mg/L 1.51844843897824 -DTXSID6048674 Css 3compartmentss Human 95% 0.2507 mg/L 0.1627 mg/L 1.54087277197296 -DTXSID6048676 Css 3compartmentss Human 95% 0.2087 mg/L 0.1176 mg/L 1.77465986394558 -DTXSID6048678 Css 3compartmentss Human 95% 5.589 mg/L 3.628 mg/L 1.54051819184123 -DTXSID6048705 Css 3compartmentss Human 95% 23.03 mg/L 9.119 mg/L 2.52549621669043 -DTXSID6048707 Css 3compartmentss Human 95% 0.0205 mg/L 3.1e-08 mg/L 661290.322580645 -DTXSID6048709 Css 3compartmentss Human 95% 7.662 mg/L 4.818 mg/L 1.59028642590286 -DTXSID6048751 Css 3compartmentss Human 95% 6.903 mg/L 2.192 mg/L 3.14917883211679 -DTXSID6048753 Css 3compartmentss Human 95% 0.533 mg/L 0.000947 mg/L 562.829989440338 -DTXSID6048755 Css 3compartmentss Human 95% 13.37 mg/L 8.179 mg/L 1.63467416554591 -DTXSID6048757 Css 3compartmentss Human 95% 1.194 mg/L 0.6894 mg/L 1.7319408181027 -DTXSID6048759 Css 3compartmentss Human 95% 3.389 mg/L 1.96 mg/L 1.72908163265306 -DTXSID6048830 Css 3compartmentss Human 95% 146.4 mg/L 71.21 mg/L 2.05589102654122 -DTXSID6048832 Css 3compartmentss Human 95% 0.251 mg/L 0.2162 mg/L 1.16096207215541 -DTXSID6048834 Css 3compartmentss Human 95% 19.46 mg/L 10.23 mg/L 1.90224828934506 -DTXSID6048836 Css 3compartmentss Human 95% 0.3046 mg/L 0.1902 mg/L 1.60147213459516 -DTXSID6048838 Css 3compartmentss Human 95% 1.963 mg/L 1.08 mg/L 1.81759259259259 -DTXSID6048880 Css 3compartmentss Human 95% 0.04997 mg/L 0.02736 mg/L 1.82638888888889 -DTXSID6048882 Css 3compartmentss Human 95% 0.08216 mg/L 0.05722 mg/L 1.43586158685774 -DTXSID6048884 Css 3compartmentss Human 95% 0.02434 mg/L 0.01878 mg/L 1.29605963791267 -DTXSID6048886 Css 3compartmentss Human 95% 0.03987 mg/L 0.03 mg/L 1.329 -DTXSID6048888 Css 3compartmentss Human 95% 0.02779 mg/L 0.01848 mg/L 1.50378787878788 -DTXSID6048911 Css 3compartmentss Human 95% 0.8046 mg/L 0.4638 mg/L 1.73479948253558 -DTXSID6048915 Css 3compartmentss Human 95% 4.241 mg/L 2.834 mg/L 1.49647141848977 -DTXSID6048917 Css 3compartmentss Human 95% 1.583 mg/L 0.2951 mg/L 5.36428329379871 -DTXSID6048919 Css 3compartmentss Human 95% 9.751 mg/L 0.8926 mg/L 10.9242661886623 -DTXSID6048961 Css 3compartmentss Human 95% 7.684 mg/L 2.666 mg/L 2.88222055513878 -DTXSID6048963 Css 3compartmentss Human 95% 5.838 mg/L 3.716 mg/L 1.57104413347686 -DTXSID6048965 Css 3compartmentss Human 95% 3.235 mg/L 1.851 mg/L 1.74770394381415 -DTXSID6048967 Css 3compartmentss Human 95% 17.41 mg/L 2.305 mg/L 7.5531453362256 -DTXSID6048969 Css 3compartmentss Human 95% 1.946 mg/L 3.18e-07 mg/L 6119496.85534591 -DTXSID6049010 Css 3compartmentss Human 95% 1.636 mg/L 1.049 mg/L 1.55958055290753 -DTXSID6049012 Css 3compartmentss Human 95% 6.515 mg/L 4.146 mg/L 1.57139411480945 -DTXSID6049016 Css 3compartmentss Human 95% 0.9302 mg/L 0.6335 mg/L 1.46835043409629 -DTXSID6049018 Css 3compartmentss Human 95% 5.779 mg/L 3.482 mg/L 1.65967834577829 -DTXSID6049060 Css 3compartmentss Human 95% 1.176 mg/L 0.1106 mg/L 10.6329113924051 -DTXSID6049062 Css 3compartmentss Human 95% 2.455 mg/L 0.6476 mg/L 3.79092032118592 -DTXSID6049064 Css 3compartmentss Human 95% 1.273 mg/L 0.7995 mg/L 1.59224515322076 -DTXSID6049066 Css 3compartmentss Human 95% 0.5745 mg/L 0.01023 mg/L 56.158357771261 -DTXSID6049068 Css 3compartmentss Human 95% 0.1139 mg/L 0.06609 mg/L 1.72340747465577 -DTXSID6049220 Css 3compartmentss Human 95% 4.697 mg/L 2.727 mg/L 1.72240557389072 -DTXSID6049222 Css 3compartmentss Human 95% 10.02 mg/L 8.974 mg/L 1.11655894807221 -DTXSID6049224 Css 3compartmentss Human 95% 10.03 mg/L 0.08816 mg/L 113.770417422868 -DTXSID6049226 Css 3compartmentss Human 95% 1.214 mg/L 0.002373 mg/L 511.588706278972 -DTXSID6049270 Css 3compartmentss Human 95% 7.592 mg/L 4.321 mg/L 1.75700069428373 -DTXSID6049303 Css 3compartmentss Human 95% 7.226 mg/L 3.174 mg/L 2.27662255828607 -DTXSID6049307 Css 3compartmentss Human 95% 24.99 mg/L 20.45 mg/L 1.22200488997555 -DTXSID6049309 Css 3compartmentss Human 95% 0.2699 mg/L 0.1857 mg/L 1.45341949380722 -DTXSID6049351 Css 3compartmentss Human 95% 4.386e-06 mg/L NA NA NA -DTXSID6049357 Css 3compartmentss Human 95% 14.15 mg/L 8.679 mg/L 1.63037216269155 -DTXSID6049359 Css 3compartmentss Human 95% 2.326 mg/L 0.2671 mg/L 8.7083489329839 -DTXSID6049432 Css 3compartmentss Human 95% 1.44 mg/L 0.9592 mg/L 1.50125104253545 -DTXSID6051306 Css 3compartmentss Human 95% 0.3028 mg/L 2e-09 mg/L 151400000 -DTXSID6051560 Css 3compartmentss Human 95% 2.297 mg/L 1.472 mg/L 1.56046195652174 -DTXSID6051566 Css 3compartmentss Human 95% 7.041 mg/L 1.11e-07 mg/L 63432432.4324324 -DTXSID6051695 Css 3compartmentss Human 95% 25.81 mg/L 45.2 mg/L 0.571017699115044 -DTXSID6051724 Css 3compartmentss Human 95% 1.603 mg/L 0.9156 mg/L 1.75076452599388 -DTXSID6051778 Css 3compartmentss Human 95% 0.8461 mg/L 0.4823 mg/L 1.75430230147211 -DTXSID6052291 Css 3compartmentss Human 95% 1.109 mg/L 0.7097 mg/L 1.56263209806961 -DTXSID6052295 Css 3compartmentss Human 95% 1.151 mg/L 0.7963 mg/L 1.44543513751099 -DTXSID6052328 Css 3compartmentss Human 95% 2.907 mg/L 2.074 mg/L 1.4016393442623 -DTXSID6052536 Css 3compartmentss Human 95% 5.179 mg/L 3.326 mg/L 1.55712567648827 -DTXSID6052619 Css 3compartmentss Human 95% 11.87 mg/L 7.855 mg/L 1.511139401655 -DTXSID6057611 Css 3compartmentss Human 95% 30.17 mg/L 22.39 mg/L 1.34747655203216 -DTXSID6057613 Css 3compartmentss Human 95% 1.756 mg/L 0.5218 mg/L 3.36527405136067 -DTXSID6057615 Css 3compartmentss Human 95% 12.05 mg/L 6.783 mg/L 1.7765000737137 -DTXSID6057617 Css 3compartmentss Human 95% 0.9343 mg/L 0.8323 mg/L 1.1225519644359 -DTXSID6057619 Css 3compartmentss Human 95% 8.253 mg/L 4.505 mg/L 1.83196448390677 -DTXSID6057661 Css 3compartmentss Human 95% 5.017 mg/L 0.5314 mg/L 9.44109898381634 -DTXSID6057663 Css 3compartmentss Human 95% 16.19 mg/L 9.056 mg/L 1.78776501766784 -DTXSID6057665 Css 3compartmentss Human 95% 0.1981 mg/L 0.1154 mg/L 1.71663778162912 -DTXSID6057667 Css 3compartmentss Human 95% 2.652 mg/L 1.962 mg/L 1.35168195718654 -DTXSID6057669 Css 3compartmentss Human 95% 21.49 mg/L 30.66 mg/L 0.700913242009132 -DTXSID6057740 Css 3compartmentss Human 95% 0.3664 mg/L 0.2272 mg/L 1.61267605633803 -DTXSID6057742 Css 3compartmentss Human 95% 28.14 mg/L 15.63 mg/L 1.80038387715931 -DTXSID6057744 Css 3compartmentss Human 95% 2.554 mg/L 1.499 mg/L 1.70380253502335 -DTXSID6057746 Css 3compartmentss Human 95% 6.829 mg/L 2.513 mg/L 2.7174691603661 -DTXSID6057748 Css 3compartmentss Human 95% 9.93 mg/L 7.659 mg/L 1.29651390520956 -DTXSID6057790 Css 3compartmentss Human 95% 8.334 mg/L 5.163 mg/L 1.61417780360256 -DTXSID6057794 Css 3compartmentss Human 95% 0.5777 mg/L 0.366 mg/L 1.57841530054645 -DTXSID6057796 Css 3compartmentss Human 95% 9.266 mg/L 5.72 mg/L 1.61993006993007 -DTXSID6057798 Css 3compartmentss Human 95% 4.69 mg/L 1.768 mg/L 2.6527149321267 -DTXSID6057821 Css 3compartmentss Human 95% 9.855 mg/L 4.448 mg/L 2.21560251798561 -DTXSID6057823 Css 3compartmentss Human 95% 6.038 mg/L 0.05637 mg/L 107.113712967891 -DTXSID6057825 Css 3compartmentss Human 95% 1.275 mg/L 0.2731 mg/L 4.66861955327719 -DTXSID6057827 Css 3compartmentss Human 95% 6.885 mg/L 4.256 mg/L 1.61771616541353 -DTXSID6057829 Css 3compartmentss Human 95% 0.2963 mg/L 0.1912 mg/L 1.54968619246862 -DTXSID70173593 Css 3compartmentss Human 95% 23.42 mg/L 0.007992 mg/L 2930.43043043043 -DTXSID7020005 Css 3compartmentss Human 95% 6.207 mg/L 3.948 mg/L 1.57218844984802 -DTXSID7020007 Css 3compartmentss Human 95% 18.06 mg/L 11.17 mg/L 1.61683079677708 -DTXSID7020053 Css 3compartmentss Human 95% 0.7232 mg/L 0.4383 mg/L 1.65001140771161 -DTXSID7020057 Css 3compartmentss Human 95% 49.12 mg/L 41.59 mg/L 1.1810531377735 -DTXSID7020138 Css 3compartmentss Human 95% 1.533 mg/L 0.9041 mg/L 1.69560889282159 -DTXSID7020182 Css 3compartmentss Human 95% 5.066 mg/L 2.35 mg/L 2.15574468085106 -DTXSID7020184 Css 3compartmentss Human 95% 962.3 mg/L 621.2 mg/L 1.54909851899549 -DTXSID7020211 Css 3compartmentss Human 95% 3.31 mg/L 0.7117 mg/L 4.65083602641562 -DTXSID7020213 Css 3compartmentss Human 95% 5.125 mg/L 2.637 mg/L 1.94349639742131 -DTXSID7020215 Css 3compartmentss Human 95% 1.581 mg/L 1.081 mg/L 1.46253469010176 -DTXSID7020261 Css 3compartmentss Human 95% 7.913 mg/L 4.942 mg/L 1.60117361392149 -DTXSID7020263 Css 3compartmentss Human 95% 71.67 mg/L 38.84 mg/L 1.84526261585994 -DTXSID7020265 Css 3compartmentss Human 95% 4.511 mg/L 2.79 mg/L 1.6168458781362 -DTXSID7020340 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID7020342 Css 3compartmentss Human 95% 0.006339 mg/L 0.004497 mg/L 1.40960640426951 -DTXSID7020344 Css 3compartmentss Human 95% 97.57 mg/L 47.67 mg/L 2.04677994545836 -DTXSID7020348 Css 3compartmentss Human 95% 15.29 mg/L 9.709 mg/L 1.57482747965805 -DTXSID7020390 Css 3compartmentss Human 95% 5.566 mg/L 2.139 mg/L 2.60215053763441 -DTXSID7020392 Css 3compartmentss Human 95% 26.31 mg/L 51.14 mg/L 0.514470082127493 -DTXSID7020398 Css 3compartmentss Human 95% 0.1072 mg/L 0.1042 mg/L 1.02879078694818 -DTXSID7020421 Css 3compartmentss Human 95% 0.8601 mg/L 0.639 mg/L 1.34600938967136 -DTXSID7020423 Css 3compartmentss Human 95% 7.623 mg/L 4.775 mg/L 1.59643979057592 -DTXSID7020427 Css 3compartmentss Human 95% 2.714 mg/L 1.821 mg/L 1.49038989566172 -DTXSID7020479 Css 3compartmentss Human 95% 0.8708 mg/L 0.4986 mg/L 1.74649017248295 -DTXSID7020504 Css 3compartmentss Human 95% 0.9197 mg/L 0.4316 mg/L 2.13090824837813 -DTXSID7020508 Css 3compartmentss Human 95% 5.557 mg/L 2.34 mg/L 2.37478632478633 -DTXSID7020550 Css 3compartmentss Human 95% 1.172 mg/L 0.8588 mg/L 1.36469492314858 -DTXSID7020552 Css 3compartmentss Human 95% 0.877 mg/L 0.3836 mg/L 2.28623566214807 -DTXSID7020558 Css 3compartmentss Human 95% 0.8034 mg/L 0.09207 mg/L 8.72596937113066 -DTXSID7020631 Css 3compartmentss Human 95% 7.022 mg/L 4.039 mg/L 1.73854914582818 -DTXSID7020635 Css 3compartmentss Human 95% 1.624 mg/L 0.2093 mg/L 7.75919732441472 -DTXSID7020681 Css 3compartmentss Human 95% 0.9288 mg/L 0.5605 mg/L 1.65709188224799 -DTXSID7020685 Css 3compartmentss Human 95% 152.5 mg/L 268.5 mg/L 0.567970204841713 -DTXSID7020687 Css 3compartmentss Human 95% 196.3 mg/L 121 mg/L 1.62231404958678 -DTXSID7020714 Css 3compartmentss Human 95% 1.633 mg/L 1.014 mg/L 1.61045364891519 -DTXSID7020716 Css 3compartmentss Human 95% 0.4887 mg/L 0.4861 mg/L 1.00534869368443 -DTXSID7020760 Css 3compartmentss Human 95% 0.156 mg/L 0.08819 mg/L 1.76890803946026 -DTXSID7020762 Css 3compartmentss Human 95% 2.1 mg/L 0.9284 mg/L 2.26195605342525 -DTXSID7020764 Css 3compartmentss Human 95% 1.922 mg/L 0.7277 mg/L 2.6411982960011 -DTXSID7020766 Css 3compartmentss Human 95% 2.496 mg/L 1.944 mg/L 1.28395061728395 -DTXSID7020768 Css 3compartmentss Human 95% 28.95 mg/L 14.93 mg/L 1.9390488948426 -DTXSID7020841 Css 3compartmentss Human 95% 15.05 mg/L 9.657 mg/L 1.55845500673087 -DTXSID7020843 Css 3compartmentss Human 95% 16.17 mg/L 4.662e-05 mg/L 346846.846846847 -DTXSID7020847 Css 3compartmentss Human 95% 14.41 mg/L 10 mg/L 1.441 -DTXSID7020893 Css 3compartmentss Human 95% 0.474 mg/L 0.2671 mg/L 1.77461624859603 -DTXSID7020897 Css 3compartmentss Human 95% 74.02 mg/L 61.57 mg/L 1.20220886795517 -DTXSID7020899 Css 3compartmentss Human 95% 9329 mg/L 9133 mg/L 1.02146063724953 -DTXSID7020920 Css 3compartmentss Human 95% 3.238 mg/L 2.798 mg/L 1.15725518227305 -DTXSID7020922 Css 3compartmentss Human 95% 8.952 mg/L 3.932 mg/L 2.27670396744659 -DTXSID7020928 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID7020972 Css 3compartmentss Human 95% 5.519 mg/L 3.698 mg/L 1.49242833964305 -DTXSID7020978 Css 3compartmentss Human 95% 5.619 mg/L 3.84 mg/L 1.46328125 -DTXSID7021027 Css 3compartmentss Human 95% 5.469 mg/L 3.577 mg/L 1.52893486161588 -DTXSID7021100 Css 3compartmentss Human 95% 17.92 mg/L 9.075 mg/L 1.97465564738292 -DTXSID7021102 Css 3compartmentss Human 95% 12.05 mg/L 6.927 mg/L 1.73956979933593 -DTXSID7021106 Css 3compartmentss Human 95% 27.63 mg/L 3.323 mg/L 8.31477580499549 -DTXSID7021150 Css 3compartmentss Human 95% 5.266 mg/L 3.696 mg/L 1.42478354978355 -DTXSID7021152 Css 3compartmentss Human 95% 7.605 mg/L 4.052 mg/L 1.87685093780849 -DTXSID7021156 Css 3compartmentss Human 95% 0.01098 mg/L 0.006757 mg/L 1.62498150066598 -DTXSID7021158 Css 3compartmentss Human 95% 4.617 mg/L 2.844 mg/L 1.62341772151899 -DTXSID7021231 Css 3compartmentss Human 95% 8.623 mg/L 4.233 mg/L 2.03708953460902 -DTXSID7021233 Css 3compartmentss Human 95% 668.4 mg/L 281.4 mg/L 2.37526652452026 -DTXSID7021235 Css 3compartmentss Human 95% 9.573 mg/L 5.326 mg/L 1.79740893728877 -DTXSID7021237 Css 3compartmentss Human 95% 1131 mg/L 669.3 mg/L 1.68982519049753 -DTXSID7021283 Css 3compartmentss Human 95% 2982 mg/L 10.88 mg/L 274.080882352941 -DTXSID7021287 Css 3compartmentss Human 95% 5.38 mg/L 3.484 mg/L 1.54420206659013 -DTXSID7021289 Css 3compartmentss Human 95% 0.84 mg/L 0.5488 mg/L 1.53061224489796 -DTXSID7021310 Css 3compartmentss Human 95% 1.664 mg/L 1.171 mg/L 1.42100768573868 -DTXSID7021312 Css 3compartmentss Human 95% 9.947 mg/L 7.534 mg/L 1.32028139102734 -DTXSID7021314 Css 3compartmentss Human 95% 2.843 mg/L 0.7194 mg/L 3.9519043647484 -DTXSID7021316 Css 3compartmentss Human 95% 172.9 mg/L 25.7 mg/L 6.72762645914397 -DTXSID7021362 Css 3compartmentss Human 95% 2.636 mg/L 1.604 mg/L 1.64339152119701 -DTXSID7021364 Css 3compartmentss Human 95% 2.45 mg/L 1.507 mg/L 1.62574651625747 -DTXSID7021366 Css 3compartmentss Human 95% 3.346 mg/L 2.089 mg/L 1.60172331258976 -DTXSID7021368 Css 3compartmentss Human 95% 1154 mg/L 5.237 mg/L 220.355165170899 -DTXSID7021495 Css 3compartmentss Human 95% 7.404 mg/L 4.667 mg/L 1.58645811013499 -DTXSID7021520 Css 3compartmentss Human 95% 7.921 mg/L 5.073 mg/L 1.56140350877193 -DTXSID7021526 Css 3compartmentss Human 95% 8.019 mg/L 4.989 mg/L 1.60733613950692 -DTXSID70215523 Css 3compartmentss Human 95% 0.6004 mg/L 0.3687 mg/L 1.62842419311093 -DTXSID7021576 Css 3compartmentss Human 95% 4.696 mg/L 3.24 mg/L 1.44938271604938 -DTXSID7021603 Css 3compartmentss Human 95% 620 mg/L 1310 mg/L 0.473282442748092 -DTXSID7021605 Css 3compartmentss Human 95% 8.012 mg/L 4.985 mg/L 1.60722166499498 -DTXSID7021607 Css 3compartmentss Human 95% 7.603 mg/L 4.889 mg/L 1.55512374718756 -DTXSID7021655 Css 3compartmentss Human 95% 7.662 mg/L 4.818 mg/L 1.59028642590286 -DTXSID7021657 Css 3compartmentss Human 95% 0.8746 mg/L 0.5793 mg/L 1.50975315035388 -DTXSID7021659 Css 3compartmentss Human 95% 8.618 mg/L 5.317 mg/L 1.62083881888283 -DTXSID7021780 Css 3compartmentss Human 95% 0.4991 mg/L 0.4099 mg/L 1.21761405220786 -DTXSID7021784 Css 3compartmentss Human 95% 16.84 mg/L 6.97 mg/L 2.41606886657102 -DTXSID7021788 Css 3compartmentss Human 95% 52.95 mg/L 30.52 mg/L 1.73492791612058 -DTXSID7021815 Css 3compartmentss Human 95% 5.982 mg/L 5.673 mg/L 1.05446853516658 -DTXSID7021817 Css 3compartmentss Human 95% 7.05 mg/L 5.632 mg/L 1.25177556818182 -DTXSID7021861 Css 3compartmentss Human 95% 1.941 mg/L 1.484 mg/L 1.30795148247978 -DTXSID7021863 Css 3compartmentss Human 95% 0.9157 mg/L 0.5981 mg/L 1.53101488045477 -DTXSID7021867 Css 3compartmentss Human 95% 1.27 mg/L 0.9375 mg/L 1.35466666666667 -DTXSID7021869 Css 3compartmentss Human 95% 0.2427 mg/L 0.1927 mg/L 1.25947067981318 -DTXSID7021940 Css 3compartmentss Human 95% 2.492 mg/L 1.216 mg/L 2.04934210526316 -DTXSID7021948 Css 3compartmentss Human 95% 1.824 mg/L 1.092 mg/L 1.67032967032967 -DTXSID7021992 Css 3compartmentss Human 95% 2.615 mg/L 1.826 mg/L 1.43209200438116 -DTXSID7021994 Css 3compartmentss Human 95% 4.175 mg/L 2.034 mg/L 2.05260570304818 -DTXSID7021996 Css 3compartmentss Human 95% 8.338 mg/L 5.121 mg/L 1.6281976176528 -DTXSID7021998 Css 3compartmentss Human 95% 6.279 mg/L 4.216 mg/L 1.48932637571157 -DTXSID7022043 Css 3compartmentss Human 95% 10.45 mg/L 6.416 mg/L 1.62874064837905 -DTXSID7022049 Css 3compartmentss Human 95% 0.2249 mg/L 0.1191 mg/L 1.88832913518052 -DTXSID7022120 Css 3compartmentss Human 95% 8.437 mg/L 0.08138 mg/L 103.674121405751 -DTXSID7022124 Css 3compartmentss Human 95% 1.673 mg/L 1.056 mg/L 1.5842803030303 -DTXSID7022128 Css 3compartmentss Human 95% 5.295 mg/L 3.371 mg/L 1.57075051913379 -DTXSID7022170 Css 3compartmentss Human 95% 0.8008 mg/L 0.4847 mg/L 1.65215597276666 -DTXSID7022172 Css 3compartmentss Human 95% 0.2305 mg/L 0.1329 mg/L 1.73438675696012 -DTXSID7022174 Css 3compartmentss Human 95% 50.9 mg/L 12.44 mg/L 4.09163987138264 -DTXSID7022253 Css 3compartmentss Human 95% 13820 mg/L 9736 mg/L 1.41947411668036 -DTXSID7022332 Css 3compartmentss Human 95% 3.766 mg/L 2.685 mg/L 1.40260707635009 -DTXSID7022382 Css 3compartmentss Human 95% 4.233 mg/L 1.047 mg/L 4.04297994269341 -DTXSID7022384 Css 3compartmentss Human 95% 1.409 mg/L 0.007447 mg/L 189.203706190412 -DTXSID7022411 Css 3compartmentss Human 95% 0.05483 mg/L 0 mg/L Inf -DTXSID7022413 Css 3compartmentss Human 95% 0.438 mg/L 0.3761 mg/L 1.16458388726403 -DTXSID7022417 Css 3compartmentss Human 95% 0.6938 mg/L 0.4395 mg/L 1.57861205915813 -DTXSID7022540 Css 3compartmentss Human 95% 353.4 mg/L 139.2 mg/L 2.53879310344828 -DTXSID7022544 Css 3compartmentss Human 95% 122.6 mg/L 69.41 mg/L 1.76631609278202 -DTXSID7022546 Css 3compartmentss Human 95% 5.966 mg/L 3.809 mg/L 1.56629036492518 -DTXSID7022590 Css 3compartmentss Human 95% 2.862 mg/L 1.585 mg/L 1.80567823343849 -DTXSID7022592 Css 3compartmentss Human 95% 8.103 mg/L 3.4e-08 mg/L 238323529.411765 -DTXSID7022594 Css 3compartmentss Human 95% 1.493 mg/L 0.02924 mg/L 51.0601915184679 -DTXSID7022598 Css 3compartmentss Human 95% 1.424 mg/L 0.4063 mg/L 3.50479940930347 -DTXSID7022629 Css 3compartmentss Human 95% 2579 mg/L 837.4 mg/L 3.07977071889181 -DTXSID7022671 Css 3compartmentss Human 95% 7.961 mg/L 3.921 mg/L 2.0303494006631 -DTXSID7022673 Css 3compartmentss Human 95% 6.052 mg/L 3.247 mg/L 1.86387434554974 -DTXSID7022679 Css 3compartmentss Human 95% 0.5215 mg/L 0.3128 mg/L 1.66719948849105 -DTXSID7022704 Css 3compartmentss Human 95% 0.05923 mg/L 0.0367 mg/L 1.61389645776567 -DTXSID7022752 Css 3compartmentss Human 95% 7.932 mg/L 5.083 mg/L 1.56049577021444 -DTXSID7022754 Css 3compartmentss Human 95% 4.467 mg/L 2.654 mg/L 1.68311981914092 -DTXSID70227808 Css 3compartmentss Human 95% 2.356 mg/L 1.323 mg/L 1.78080120937264 -DTXSID7022833 Css 3compartmentss Human 95% 0.2124 mg/L 0.1433 mg/L 1.48220516399163 -DTXSID7022835 Css 3compartmentss Human 95% 8.129 mg/L 8.122 mg/L 1.00086185668555 -DTXSID7022837 Css 3compartmentss Human 95% 50.29 mg/L 24.94 mg/L 2.01643945469126 -DTXSID7022839 Css 3compartmentss Human 95% 20.79 mg/L 4.667e-05 mg/L 445468.180844225 -DTXSID7022883 Css 3compartmentss Human 95% 14.17 mg/L 7.464 mg/L 1.89844587352626 -DTXSID7022910 Css 3compartmentss Human 95% 5.669 mg/L 3.628 mg/L 1.56256890848953 -DTXSID7022912 Css 3compartmentss Human 95% 6.878 mg/L 3.855 mg/L 1.78417639429313 -DTXSID7022914 Css 3compartmentss Human 95% 19.1 mg/L 10.62 mg/L 1.7984934086629 -DTXSID7022918 Css 3compartmentss Human 95% 7.391 mg/L 4.768 mg/L 1.55012583892617 -DTXSID7022966 Css 3compartmentss Human 95% 0.303 mg/L 0.04836 mg/L 6.26550868486352 -DTXSID7022968 Css 3compartmentss Human 95% 0.05914 mg/L 0.03523 mg/L 1.67868294067556 -DTXSID7023011 Css 3compartmentss Human 95% 42.24 mg/L 23.33 mg/L 1.8105443634805 -DTXSID7023019 Css 3compartmentss Human 95% 2.862 mg/L 1.862 mg/L 1.53705692803437 -DTXSID7023061 Css 3compartmentss Human 95% 1.968 mg/L 1.178 mg/L 1.67062818336163 -DTXSID7023063 Css 3compartmentss Human 95% 1467 mg/L 866.8 mg/L 1.69243193354868 -DTXSID7023065 Css 3compartmentss Human 95% 4.435 mg/L 3.384 mg/L 1.31057919621749 -DTXSID7023067 Css 3compartmentss Human 95% 8.827 mg/L 1.815 mg/L 4.8633608815427 -DTXSID7023140 Css 3compartmentss Human 95% 9.313 mg/L 1.897 mg/L 4.90933052187665 -DTXSID7023146 Css 3compartmentss Human 95% 5.615 mg/L 3.628 mg/L 1.54768467475193 -DTXSID7023148 Css 3compartmentss Human 95% 90.93 mg/L 53.38 mg/L 1.7034469838891 -DTXSID7023190 Css 3compartmentss Human 95% 2.075 mg/L 0.8538 mg/L 2.43031154837198 -DTXSID7023192 Css 3compartmentss Human 95% 7.454 mg/L 4.649 mg/L 1.60335556033556 -DTXSID7023194 Css 3compartmentss Human 95% 0.02195 mg/L 0.01596 mg/L 1.37531328320802 -DTXSID7023196 Css 3compartmentss Human 95% 32.33 mg/L 19.21 mg/L 1.68297761582509 -DTXSID7023198 Css 3compartmentss Human 95% 15.04 mg/L 8.832 mg/L 1.70289855072464 -DTXSID7023221 Css 3compartmentss Human 95% 0.6574 mg/L 0.2233 mg/L 2.94402149574563 -DTXSID7023225 Css 3compartmentss Human 95% 21.33 mg/L 14.69 mg/L 1.45200816882233 -DTXSID7023227 Css 3compartmentss Human 95% 329.1 mg/L 156.3 mg/L 2.10556621880998 -DTXSID7023273 Css 3compartmentss Human 95% 117.5 mg/L 246.1 mg/L 0.477448191791955 -DTXSID7023277 Css 3compartmentss Human 95% 1.481 mg/L 1.517 mg/L 0.976268951878708 -DTXSID7023279 Css 3compartmentss Human 95% 7.871 mg/L 4.467 mg/L 1.76203268412805 -DTXSID7023300 Css 3compartmentss Human 95% 1.882 mg/L 1.268 mg/L 1.48422712933754 -DTXSID7023302 Css 3compartmentss Human 95% 1.259 mg/L 0.9579 mg/L 1.31433343772836 -DTXSID7023350 Css 3compartmentss Human 95% 10.54 mg/L 6.99 mg/L 1.50786838340486 -DTXSID7023352 Css 3compartmentss Human 95% 0.04081 mg/L 0 mg/L Inf -DTXSID7023356 Css 3compartmentss Human 95% 18.24 mg/L 10.42 mg/L 1.75047984644914 -DTXSID7023435 Css 3compartmentss Human 95% 4.569 mg/L 3.04 mg/L 1.50296052631579 -DTXSID7023437 Css 3compartmentss Human 95% 0.9489 mg/L 0.6055 mg/L 1.56713459950454 -DTXSID7023481 Css 3compartmentss Human 95% 5.68 mg/L 0.7166 mg/L 7.92631872732347 -DTXSID7023485 Css 3compartmentss Human 95% 3.227 mg/L 2.031 mg/L 1.58887247661251 -DTXSID7023487 Css 3compartmentss Human 95% 2.083 mg/L 2.213 mg/L 0.941256213285133 -DTXSID7023510 Css 3compartmentss Human 95% 0.4964 mg/L 0.3026 mg/L 1.64044943820225 -DTXSID7023512 Css 3compartmentss Human 95% 2.192 mg/L 1.398 mg/L 1.56795422031474 -DTXSID7023514 Css 3compartmentss Human 95% 125.6 mg/L 4.06 mg/L 30.935960591133 -DTXSID7023516 Css 3compartmentss Human 95% 4.049 mg/L 2.132 mg/L 1.89915572232645 -DTXSID7023518 Css 3compartmentss Human 95% 6.794 mg/L 0.4635 mg/L 14.6580366774542 -DTXSID7023566 Css 3compartmentss Human 95% 1671 mg/L 3522 mg/L 0.474446337308348 -DTXSID7023568 Css 3compartmentss Human 95% 0.4343 mg/L 0.2527 mg/L 1.7186387020182 -DTXSID7023643 Css 3compartmentss Human 95% 14.28 mg/L 18.07 mg/L 0.790260099612618 -DTXSID7023645 Css 3compartmentss Human 95% 1.808 mg/L 2.211 mg/L 0.817729534147445 -DTXSID7023693 Css 3compartmentss Human 95% 12.17 mg/L 6.573 mg/L 1.85151376844668 -DTXSID7023697 Css 3compartmentss Human 95% 1.106 mg/L 0.5817 mg/L 1.90132370637786 -DTXSID7023699 Css 3compartmentss Human 95% 14.49 mg/L 7.906 mg/L 1.83278522641032 -DTXSID7023722 Css 3compartmentss Human 95% 0.1298 mg/L 0.07424 mg/L 1.74838362068966 -DTXSID7023724 Css 3compartmentss Human 95% 4.675 mg/L 6.7 mg/L 0.697761194029851 -DTXSID7023853 Css 3compartmentss Human 95% 1391 mg/L 796.3 mg/L 1.74682908451589 -DTXSID7023932 Css 3compartmentss Human 95% 40.52 mg/L 0.2853 mg/L 142.025937609534 -DTXSID7023936 Css 3compartmentss Human 95% 2.866 mg/L 0.9071 mg/L 3.15951934737074 -DTXSID7023938 Css 3compartmentss Human 95% 20.53 mg/L 8.87 mg/L 2.31454340473506 -DTXSID7023980 Css 3compartmentss Human 95% 9.516 mg/L 5.144 mg/L 1.84992223950233 -DTXSID7024035 Css 3compartmentss Human 95% 1022 mg/L 600.3 mg/L 1.70248209228719 -DTXSID7024081 Css 3compartmentss Human 95% 2.251 mg/L 1.787 mg/L 1.25965304980414 -DTXSID7024085 Css 3compartmentss Human 95% 9.06 mg/L 5.687 mg/L 1.59310708633726 -DTXSID7024087 Css 3compartmentss Human 95% 3.329 mg/L 3.267 mg/L 1.01897765534129 -DTXSID7024110 Css 3compartmentss Human 95% 3.144 mg/L 0.0009497 mg/L 3310.5191112983 -DTXSID7024112 Css 3compartmentss Human 95% 204.6 mg/L 118 mg/L 1.73389830508475 -DTXSID7024160 Css 3compartmentss Human 95% 831.4 mg/L 594.5 mg/L 1.39848612279226 -DTXSID7024164 Css 3compartmentss Human 95% 78.35 mg/L 44.69 mg/L 1.75318863280376 -DTXSID7024166 Css 3compartmentss Human 95% 5.827 mg/L 3.904 mg/L 1.49257172131148 -DTXSID7024241 Css 3compartmentss Human 95% 833.2 mg/L 1760 mg/L 0.473409090909091 -DTXSID7024245 Css 3compartmentss Human 95% 49.14 mg/L 0.9174 mg/L 53.5644211903205 -DTXSID7024291 Css 3compartmentss Human 95% 3.207 mg/L 0.326 mg/L 9.83742331288343 -DTXSID7024299 Css 3compartmentss Human 95% 1.914 mg/L 0.7904 mg/L 2.42155870445344 -DTXSID7024328 Css 3compartmentss Human 95% 1.868 mg/L 0.5509 mg/L 3.39081502995099 -DTXSID7024376 Css 3compartmentss Human 95% 11.83 mg/L 3.089 mg/L 3.82971835545484 -DTXSID7024409 Css 3compartmentss Human 95% 1.118 mg/L 0.6507 mg/L 1.71814968495466 -DTXSID7024455 Css 3compartmentss Human 95% 1.93 mg/L 1.209 mg/L 1.59636062861869 -DTXSID7024457 Css 3compartmentss Human 95% 0.9426 mg/L 0.64 mg/L 1.4728125 -DTXSID7024532 Css 3compartmentss Human 95% 0.1034 mg/L 0.071 mg/L 1.45633802816901 -DTXSID7024534 Css 3compartmentss Human 95% 0.998 mg/L 0.5315 mg/L 1.87770460959548 -DTXSID7024538 Css 3compartmentss Human 95% 8.789 mg/L 4.201 mg/L 2.09212092358962 -DTXSID7024580 Css 3compartmentss Human 95% 5.674 mg/L 3.296 mg/L 1.72148058252427 -DTXSID7024586 Css 3compartmentss Human 95% 0.4749 mg/L 0.3591 mg/L 1.32247284878864 -DTXSID7024667 Css 3compartmentss Human 95% 7.79 mg/L 5.179 mg/L 1.5041513805754 -DTXSID7024740 Css 3compartmentss Human 95% 11.03 mg/L 6.917 mg/L 1.59462194593032 -DTXSID7024742 Css 3compartmentss Human 95% 1.412e-06 mg/L 0 mg/L Inf -DTXSID7024827 Css 3compartmentss Human 95% 71.49 mg/L 3.354 mg/L 21.3148479427549 -DTXSID7024873 Css 3compartmentss Human 95% 8.074 mg/L 5.1 mg/L 1.58313725490196 -DTXSID7024875 Css 3compartmentss Human 95% 1.223 mg/L 0.7879 mg/L 1.55222744003046 -DTXSID7024902 Css 3compartmentss Human 95% 0.3897 mg/L 0.2642 mg/L 1.47501892505678 -DTXSID7024904 Css 3compartmentss Human 95% 815.8 mg/L 473.7 mg/L 1.72218703820984 -DTXSID7024906 Css 3compartmentss Human 95% 9.222 mg/L 4.993 mg/L 1.84698578009213 -DTXSID7024950 Css 3compartmentss Human 95% 3.618 mg/L 2.393 mg/L 1.51190973673214 -DTXSID7024956 Css 3compartmentss Human 95% 8.468 mg/L 4.803 mg/L 1.76306475119717 -DTXSID7025001 Css 3compartmentss Human 95% 9.315 mg/L 4.631 mg/L 2.01144461239473 -DTXSID7025003 Css 3compartmentss Human 95% 22.47 mg/L 11.17 mg/L 2.01163831692032 -DTXSID7025005 Css 3compartmentss Human 95% 9.747 mg/L 7.582 mg/L 1.28554471115801 -DTXSID7025051 Css 3compartmentss Human 95% 7.023 mg/L 4.676 mg/L 1.5019247219846 -DTXSID7025053 Css 3compartmentss Human 95% 0.01847 mg/L 1.101e-06 mg/L 16775.6584922797 -DTXSID7025055 Css 3compartmentss Human 95% 0.004812 mg/L 0 mg/L Inf -DTXSID7025130 Css 3compartmentss Human 95% 15.13 mg/L 3.228 mg/L 4.68711276332094 -DTXSID7025132 Css 3compartmentss Human 95% 32.88 mg/L 14.88 mg/L 2.20967741935484 -DTXSID7025134 Css 3compartmentss Human 95% 4.445 mg/L 4.914 mg/L 0.904558404558405 -DTXSID7025136 Css 3compartmentss Human 95% 2.682 mg/L 2.66 mg/L 1.00827067669173 -DTXSID7025138 Css 3compartmentss Human 95% 0.3383 mg/L 0.2359 mg/L 1.43408223823654 -DTXSID7025180 Css 3compartmentss Human 95% 12.18 mg/L 7.149 mg/L 1.70373478808225 -DTXSID7025215 Css 3compartmentss Human 95% 0.01777 mg/L 0 mg/L Inf -DTXSID7025217 Css 3compartmentss Human 95% 137.9 mg/L 181 mg/L 0.761878453038674 -DTXSID7025219 Css 3compartmentss Human 95% 32.01 mg/L 11.79 mg/L 2.71501272264631 -DTXSID7025269 Css 3compartmentss Human 95% 7.711 mg/L 9.072 mg/L 0.849977954144621 -DTXSID7025346 Css 3compartmentss Human 95% 0.5703 mg/L 0.4618 mg/L 1.23495019488956 -DTXSID7025390 Css 3compartmentss Human 95% 0.03642 mg/L 1.074e-06 mg/L 33910.6145251397 -DTXSID7025394 Css 3compartmentss Human 95% 0.7259 mg/L 0.7042 mg/L 1.03081510934394 -DTXSID7025421 Css 3compartmentss Human 95% 2.479 mg/L 1.589 mg/L 1.56010069225928 -DTXSID7025423 Css 3compartmentss Human 95% 0.8826 mg/L 0.6708 mg/L 1.31574239713775 -DTXSID7025425 Css 3compartmentss Human 95% 7.715 mg/L 4.778 mg/L 1.61469233989117 -DTXSID7025427 Css 3compartmentss Human 95% 3.442 mg/L 2.366 mg/L 1.45477599323753 -DTXSID7025429 Css 3compartmentss Human 95% 12.01 mg/L 2.604 mg/L 4.61213517665131 -DTXSID7025479 Css 3compartmentss Human 95% 2.981 mg/L 2.973 mg/L 1.00269088462832 -DTXSID7025502 Css 3compartmentss Human 95% 1.893 mg/L 1.908 mg/L 0.992138364779874 -DTXSID7025506 Css 3compartmentss Human 95% 13.83 mg/L 2.188 mg/L 6.32084095063985 -DTXSID7025508 Css 3compartmentss Human 95% 7.033 mg/L 4.307 mg/L 1.63292314836313 -DTXSID7025558 Css 3compartmentss Human 95% 4.11 mg/L 2.586 mg/L 1.58932714617169 -DTXSID7025633 Css 3compartmentss Human 95% 1.584 mg/L 1.027 mg/L 1.54235637779942 -DTXSID7025635 Css 3compartmentss Human 95% 0.5176 mg/L 0.3558 mg/L 1.45474985947161 -DTXSID7025637 Css 3compartmentss Human 95% 16.23 mg/L 9.394 mg/L 1.72769853097722 -DTXSID7025639 Css 3compartmentss Human 95% 12.08 mg/L 6.935 mg/L 1.74188896899784 -DTXSID7025689 Css 3compartmentss Human 95% 37.16 mg/L 34.01 mg/L 1.09261981770068 -DTXSID7025716 Css 3compartmentss Human 95% 1.06 mg/L 0.6608 mg/L 1.60411622276029 -DTXSID7025764 Css 3compartmentss Human 95% 0.7627 mg/L 0.4974 mg/L 1.53337354242059 -DTXSID7025768 Css 3compartmentss Human 95% 3.189 mg/L 1.98 mg/L 1.61060606060606 -DTXSID7025895 Css 3compartmentss Human 95% 2.213 mg/L 1.398 mg/L 1.5829756795422 -DTXSID7025924 Css 3compartmentss Human 95% 0.06476 mg/L 0.04699 mg/L 1.37816556714195 -DTXSID7025926 Css 3compartmentss Human 95% 0.1308 mg/L 0.08841 mg/L 1.47947064811673 -DTXSID7025972 Css 3compartmentss Human 95% 3.768 mg/L 2.134 mg/L 1.76569821930647 -DTXSID7026025 Css 3compartmentss Human 95% 8.505 mg/L 5.69 mg/L 1.49472759226714 -DTXSID7026029 Css 3compartmentss Human 95% 55.62 mg/L 32.51 mg/L 1.7108581974777 -DTXSID7026102 Css 3compartmentss Human 95% 83.56 mg/L 63.4 mg/L 1.31798107255521 -DTXSID7026108 Css 3compartmentss Human 95% 0.04488 mg/L 0.03436 mg/L 1.30616996507567 -DTXSID7026156 Css 3compartmentss Human 95% 0.9769 mg/L 0.5824 mg/L 1.67736950549451 -DTXSID7026231 Css 3compartmentss Human 95% 1.42 mg/L 0.3213 mg/L 4.41954559601618 -DTXSID7026235 Css 3compartmentss Human 95% 11.63 mg/L 7.182 mg/L 1.6193260930103 -DTXSID7026285 Css 3compartmentss Human 95% 0.05603 mg/L 0.03593 mg/L 1.55942109657668 -DTXSID7026314 Css 3compartmentss Human 95% 0.879 mg/L 0.6128 mg/L 1.43439947780679 -DTXSID7026318 Css 3compartmentss Human 95% 78.8 mg/L 1.537 mg/L 51.2687052700065 -DTXSID7026368 Css 3compartmentss Human 95% 24.62 mg/L 14.11 mg/L 1.74486180014174 -DTXSID7026499 Css 3compartmentss Human 95% 3.296 mg/L 2.069 mg/L 1.59304011599807 -DTXSID7026520 Css 3compartmentss Human 95% 10.91 mg/L 6.714 mg/L 1.62496276437295 -DTXSID7026526 Css 3compartmentss Human 95% 1.694 mg/L 0.7455 mg/L 2.27230046948357 -DTXSID7026528 Css 3compartmentss Human 95% 3.357 mg/L 1.543 mg/L 2.17563188593649 -DTXSID7026572 Css 3compartmentss Human 95% 4.056 mg/L 0.3789 mg/L 10.7046714172605 -DTXSID7026605 Css 3compartmentss Human 95% 2.833 mg/L 3.273 mg/L 0.865566758325695 -DTXSID7026609 Css 3compartmentss Human 95% 0.5114 mg/L 0.3585 mg/L 1.42649930264993 -DTXSID7026653 Css 3compartmentss Human 95% 16.05 mg/L 11.67 mg/L 1.37532133676093 -DTXSID7026655 Css 3compartmentss Human 95% 1.344 mg/L 1.02 mg/L 1.31764705882353 -DTXSID7026863 Css 3compartmentss Human 95% 5.103 mg/L 2.285 mg/L 2.23326039387309 -DTXSID7026867 Css 3compartmentss Human 95% 2.005 mg/L 1.268 mg/L 1.58123028391167 -DTXSID7026994 Css 3compartmentss Human 95% 0.2505 mg/L 0 mg/L Inf -DTXSID7027041 Css 3compartmentss Human 95% 0.6051 mg/L 0.4228 mg/L 1.43117313150426 -DTXSID7027043 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID7027097 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID7027099 Css 3compartmentss Human 95% 0.06154 mg/L 0 mg/L Inf -DTXSID7027120 Css 3compartmentss Human 95% 8.433 mg/L 5.091 mg/L 1.65645256334708 -DTXSID7027170 Css 3compartmentss Human 95% 7.122 mg/L 4.477 mg/L 1.59079740897923 -DTXSID7027174 Css 3compartmentss Human 95% 3.126 mg/L 2.121 mg/L 1.47383309759547 -DTXSID7027253 Css 3compartmentss Human 95% 0.1002 mg/L 0.06408 mg/L 1.56367041198502 -DTXSID7027259 Css 3compartmentss Human 95% 2.069 mg/L 1.405 mg/L 1.47259786476868 -DTXSID7027334 Css 3compartmentss Human 95% 1.049 mg/L 0.6933 mg/L 1.51305351218809 -DTXSID7027386 Css 3compartmentss Human 95% 120.8 mg/L 3.158 mg/L 38.2520582647245 -DTXSID7027388 Css 3compartmentss Human 95% 0.4667 mg/L 1e-08 mg/L 46670000 -DTXSID7027413 Css 3compartmentss Human 95% 8.117 mg/L 4.866 mg/L 1.66810521989314 -DTXSID7027461 Css 3compartmentss Human 95% 1.68 mg/L 1.197 mg/L 1.40350877192982 -DTXSID7027540 Css 3compartmentss Human 95% 2.617 mg/L 1.91 mg/L 1.37015706806283 -DTXSID7027542 Css 3compartmentss Human 95% 91.36 mg/L 53.51 mg/L 1.70734442160344 -DTXSID7027544 Css 3compartmentss Human 95% 7.549 mg/L 4.61 mg/L 1.63752711496746 -DTXSID7027594 Css 3compartmentss Human 95% 10.07 mg/L 5.342 mg/L 1.88506177461625 -DTXSID7027596 Css 3compartmentss Human 95% 2.315 mg/L 1.574 mg/L 1.4707750952986 -DTXSID7027625 Css 3compartmentss Human 95% 1.688 mg/L 6.2e-08 mg/L 27225806.4516129 -DTXSID7027756 Css 3compartmentss Human 95% 1.241 mg/L 0.7423 mg/L 1.67183079617405 -DTXSID7027833 Css 3compartmentss Human 95% 2.522 mg/L 1.95 mg/L 1.29333333333333 -DTXSID7027835 Css 3compartmentss Human 95% 6.933 mg/L 4.213 mg/L 1.64562069784002 -DTXSID7027837 Css 3compartmentss Human 95% 7.435 mg/L 4.65 mg/L 1.5989247311828 -DTXSID7027887 Css 3compartmentss Human 95% 1.067 mg/L 3.6e-08 mg/L 29638888.8888889 -DTXSID7027916 Css 3compartmentss Human 95% 26.06 mg/L 14.52 mg/L 1.79476584022039 -DTXSID7027966 Css 3compartmentss Human 95% 7.323 mg/L 4.489 mg/L 1.63132100690577 -DTXSID7028011 Css 3compartmentss Human 95% 0.0006601 mg/L 0 mg/L Inf -DTXSID7028013 Css 3compartmentss Human 95% 0.04671 mg/L 0.02787 mg/L 1.67599569429494 -DTXSID7028015 Css 3compartmentss Human 95% 1.369 mg/L 0.9176 mg/L 1.49193548387097 -DTXSID7028300 Css 3compartmentss Human 95% 4.104 mg/L 1.748 mg/L 2.34782608695652 -DTXSID7028306 Css 3compartmentss Human 95% 858.7 mg/L 2952 mg/L 0.290887533875339 -DTXSID7028774 Css 3compartmentss Human 95% 9782 mg/L 9279 mg/L 1.05420842763229 -DTXSID7028776 Css 3compartmentss Human 95% 45.67 mg/L 91.62 mg/L 0.498471949356036 -DTXSID7029110 Css 3compartmentss Human 95% 3.648 mg/L 2.759 mg/L 1.32221819499819 -DTXSID7029160 Css 3compartmentss Human 95% 11190 mg/L 9730 mg/L 1.15005138746146 -DTXSID7029164 Css 3compartmentss Human 95% 4.936 mg/L 3.14 mg/L 1.57197452229299 -DTXSID7029166 Css 3compartmentss Human 95% 8.757 mg/L 4.402 mg/L 1.9893230349841 -DTXSID7029241 Css 3compartmentss Human 95% 5.301 mg/L 0.07482 mg/L 70.850040096231 -DTXSID7029247 Css 3compartmentss Human 95% 0.7999 mg/L 0.7029 mg/L 1.1379997154645 -DTXSID7029249 Css 3compartmentss Human 95% 1.106 mg/L 0.7287 mg/L 1.51777137367915 -DTXSID7029299 Css 3compartmentss Human 95% 2137 mg/L 9739 mg/L 0.219427045897936 -DTXSID7029320 Css 3compartmentss Human 95% 234.1 mg/L 34.38 mg/L 6.80919139034322 -DTXSID7029611 Css 3compartmentss Human 95% 0.2643 mg/L 0.1191 mg/L 2.2191435768262 -DTXSID7029617 Css 3compartmentss Human 95% 7.122 mg/L 4.477 mg/L 1.59079740897923 -DTXSID7029619 Css 3compartmentss Human 95% 11.09 mg/L 6.759 mg/L 1.64077526261281 -DTXSID7029665 Css 3compartmentss Human 95% 0.2871 mg/L 0.1947 mg/L 1.47457627118644 -DTXSID7029871 Css 3compartmentss Human 95% 4.235 mg/L 0.5169 mg/L 8.19307409556974 -DTXSID7029879 Css 3compartmentss Human 95% 3.481 mg/L 0.8719 mg/L 3.99243032457851 -DTXSID7029904 Css 3compartmentss Human 95% 2415 mg/L 10.59 mg/L 228.045325779037 -DTXSID7030307 Css 3compartmentss Human 95% 0.8966 mg/L 0.4311 mg/L 2.0797958710276 -DTXSID7030432 Css 3compartmentss Human 95% 5.351 mg/L 3.628 mg/L 1.47491730981257 -DTXSID7030698 Css 3compartmentss Human 95% 5.559 mg/L 3.261 mg/L 1.70469181232751 -DTXSID7031294 Css 3compartmentss Human 95% 7.295 mg/L 4.541 mg/L 1.60647434485796 -DTXSID7031458 Css 3compartmentss Human 95% 3.194 mg/L 2.404 mg/L 1.32861896838602 -DTXSID7031531 Css 3compartmentss Human 95% 13730 mg/L 8133 mg/L 1.68818394196483 -DTXSID7031797 Css 3compartmentss Human 95% 0.5454 mg/L 0.3522 mg/L 1.54855195911414 -DTXSID7031903 Css 3compartmentss Human 95% 8.387 mg/L 5.175 mg/L 1.62067632850242 -DTXSID7032004 Css 3compartmentss Human 95% 4.906 mg/L 2.267 mg/L 2.16409351565946 -DTXSID7032345 Css 3compartmentss Human 95% 1828 mg/L 1042 mg/L 1.75431861804223 -DTXSID7032393 Css 3compartmentss Human 95% 36.46 mg/L 4.327 mg/L 8.42616131268777 -DTXSID7032424 Css 3compartmentss Human 95% 8.375 mg/L 5.381 mg/L 1.55640215573314 -DTXSID7032470 Css 3compartmentss Human 95% 28.45 mg/L 6.627 mg/L 4.29304360947638 -DTXSID7032474 Css 3compartmentss Human 95% 10.47 mg/L 5.466 mg/L 1.91547749725576 -DTXSID7032551 Css 3compartmentss Human 95% 36.22 mg/L 5.263 mg/L 6.88200646019381 -DTXSID7032553 Css 3compartmentss Human 95% 4695 mg/L 6989 mg/L 0.671769924166547 -DTXSID7032555 Css 3compartmentss Human 95% 22.77 mg/L 10.44 mg/L 2.18103448275862 -DTXSID7032559 Css 3compartmentss Human 95% 2.766 mg/L 8.228e-06 mg/L 336169.178415168 -DTXSID7032630 Css 3compartmentss Human 95% 17.84 mg/L 11.15 mg/L 1.6 -DTXSID7032638 Css 3compartmentss Human 95% 43.52 mg/L 5.498 mg/L 7.91560567479083 -DTXSID7032688 Css 3compartmentss Human 95% 3.025 mg/L 0.001082 mg/L 2795.74861367837 -DTXSID7033105 Css 3compartmentss Human 95% 7.818 mg/L 4.644 mg/L 1.68346253229974 -DTXSID7034042 Css 3compartmentss Human 95% 0.02205 mg/L 5.471e-05 mg/L 403.034180222994 -DTXSID7034250 Css 3compartmentss Human 95% 0.8317 mg/L 0.1962 mg/L 4.23904179408767 -DTXSID7034252 Css 3compartmentss Human 95% 3.453 mg/L 3.962 mg/L 0.871529530540131 -DTXSID7034383 Css 3compartmentss Human 95% 286.2 mg/L 164.8 mg/L 1.73665048543689 -DTXSID7034460 Css 3compartmentss Human 95% 163 mg/L 69.35 mg/L 2.35039653929344 -DTXSID7034545 Css 3compartmentss Human 95% 2.256 mg/L 1.024 mg/L 2.203125 -DTXSID7034549 Css 3compartmentss Human 95% 0.5292 mg/L 0.3341 mg/L 1.583956899132 -DTXSID7034624 Css 3compartmentss Human 95% 47.75 mg/L 14.72 mg/L 3.24388586956522 -DTXSID7034672 Css 3compartmentss Human 95% 11.68 mg/L 10.83 mg/L 1.07848568790397 -DTXSID7034674 Css 3compartmentss Human 95% 2.491 mg/L 0.6023 mg/L 4.13581271791466 -DTXSID7034676 Css 3compartmentss Human 95% 6.183 mg/L 2.866 mg/L 2.15736217725052 -DTXSID7034753 Css 3compartmentss Human 95% 68.17 mg/L 39.93 mg/L 1.70723766591535 -DTXSID7034836 Css 3compartmentss Human 95% 11.01 mg/L 6.685 mg/L 1.6469708302169 -DTXSID7034961 Css 3compartmentss Human 95% 2.66 mg/L 1.689 mg/L 1.5748963883955 -DTXSID7035010 Css 3compartmentss Human 95% 257.8 mg/L 142.4 mg/L 1.81039325842697 -DTXSID7035305 Css 3compartmentss Human 95% 2.764 mg/L 1.932 mg/L 1.43064182194617 -DTXSID7037131 Css 3compartmentss Human 95% 166.6 mg/L 79.31 mg/L 2.10061782877317 -DTXSID7037262 Css 3compartmentss Human 95% 1.263 mg/L 0.6626 mg/L 1.9061273769997 -DTXSID7037478 Css 3compartmentss Human 95% 1.085 mg/L 0.6775 mg/L 1.60147601476015 -DTXSID7037551 Css 3compartmentss Human 95% 0.8598 mg/L 0.6224 mg/L 1.38142673521851 -DTXSID7037553 Css 3compartmentss Human 95% 494.7 mg/L 342.1 mg/L 1.44606840105232 -DTXSID7037555 Css 3compartmentss Human 95% 3.144 mg/L 0.0009497 mg/L 3310.5191112983 -DTXSID7037680 Css 3compartmentss Human 95% 6.641 mg/L 3.689 mg/L 1.80021686093792 -DTXSID7037684 Css 3compartmentss Human 95% 0.7922 mg/L 0.4939 mg/L 1.60396841465884 -DTXSID7037715 Css 3compartmentss Human 95% 6.398 mg/L 3.335 mg/L 1.91844077961019 -DTXSID7037717 Css 3compartmentss Human 95% 2.751 mg/L 0.7902 mg/L 3.48139711465452 -DTXSID7038317 Css 3compartmentss Human 95% 322.9 mg/L 210 mg/L 1.53761904761905 -DTXSID7038814 Css 3compartmentss Human 95% 1.431 mg/L 0.9295 mg/L 1.53953738569123 -DTXSID7038864 Css 3compartmentss Human 95% 2434 mg/L 9739 mg/L 0.249922990040045 -DTXSID7040150 Css 3compartmentss Human 95% 4054 mg/L 2350 mg/L 1.72510638297872 -DTXSID7040152 Css 3compartmentss Human 95% 6.53 mg/L 4.16 mg/L 1.56971153846154 -DTXSID7040154 Css 3compartmentss Human 95% 0.403 mg/L 0.2945 mg/L 1.36842105263158 -DTXSID7040283 Css 3compartmentss Human 95% 450.8 mg/L 644.8 mg/L 0.699131513647643 -DTXSID7040285 Css 3compartmentss Human 95% 1.147 mg/L 0.7532 mg/L 1.52283590015932 -DTXSID7040287 Css 3compartmentss Human 95% 0.6745 mg/L 0.2183 mg/L 3.08978469995419 -DTXSID7040289 Css 3compartmentss Human 95% 30.98 mg/L 18.32 mg/L 1.6910480349345 -DTXSID7040316 Css 3compartmentss Human 95% 5.51 mg/L 4.651 mg/L 1.18469146420125 -DTXSID7040360 Css 3compartmentss Human 95% 20.32 mg/L 9.464 mg/L 2.14708368554522 -DTXSID7040362 Css 3compartmentss Human 95% 20.6 mg/L 8.425 mg/L 2.44510385756677 -DTXSID7040449 Css 3compartmentss Human 95% 12.71 mg/L 7.745 mg/L 1.64105874757908 -DTXSID7040526 Css 3compartmentss Human 95% 5.61 mg/L 3.701 mg/L 1.5158065387733 -DTXSID7040609 Css 3compartmentss Human 95% 5.487 mg/L 3.407 mg/L 1.6105077781039 -DTXSID7040651 Css 3compartmentss Human 95% 8.301 mg/L 6.093 mg/L 1.36238306253077 -DTXSID7040653 Css 3compartmentss Human 95% 14.81 mg/L 6.925 mg/L 2.13862815884477 -DTXSID7040657 Css 3compartmentss Human 95% 2.702 mg/L 0.003093 mg/L 873.585515680569 -DTXSID7040732 Css 3compartmentss Human 95% 2.542 mg/L 1.645 mg/L 1.54528875379939 -DTXSID7040734 Css 3compartmentss Human 95% 16.76 mg/L 4.161 mg/L 4.02787791396299 -DTXSID7040736 Css 3compartmentss Human 95% 1.076 mg/L 0.6054 mg/L 1.77733729765444 -DTXSID7040738 Css 3compartmentss Human 95% 7.25 mg/L 0.5185 mg/L 13.9826422372228 -DTXSID7040784 Css 3compartmentss Human 95% 0.04664 mg/L 0 mg/L Inf -DTXSID7040788 Css 3compartmentss Human 95% 9.38 mg/L 6.308 mg/L 1.48700063411541 -DTXSID7040948 Css 3compartmentss Human 95% 34.84 mg/L 20.11 mg/L 1.73247140726007 -DTXSID7040990 Css 3compartmentss Human 95% 16.8 mg/L 8.683 mg/L 1.93481515605206 -DTXSID7041045 Css 3compartmentss Human 95% 5.496 mg/L 3.628 mg/L 1.5148842337376 -DTXSID7041047 Css 3compartmentss Human 95% 4.416 mg/L 2.158 mg/L 2.04633920296571 -DTXSID7041091 Css 3compartmentss Human 95% 2.422 mg/L 1.483 mg/L 1.63317599460553 -DTXSID7041097 Css 3compartmentss Human 95% 8.335 mg/L 0.5271 mg/L 15.8129387213053 -DTXSID7041126 Css 3compartmentss Human 95% 1756 mg/L 693.8 mg/L 2.53098875756702 -DTXSID7041178 Css 3compartmentss Human 95% 31.69 mg/L 18.39 mg/L 1.72321914083741 -DTXSID7041209 Css 3compartmentss Human 95% 6.025 mg/L 6.96 mg/L 0.86566091954023 -DTXSID7041253 Css 3compartmentss Human 95% 5.481 mg/L 3.224 mg/L 1.70006203473945 -DTXSID7041336 Css 3compartmentss Human 95% 561 mg/L 379.6 mg/L 1.47787144362487 -DTXSID7041388 Css 3compartmentss Human 95% 2.007 mg/L 1.323 mg/L 1.51700680272109 -DTXSID7041411 Css 3compartmentss Human 95% 7.389 mg/L 4.003 mg/L 1.8458656007994 -DTXSID7041417 Css 3compartmentss Human 95% 3.219 mg/L 2.188 mg/L 1.47120658135283 -DTXSID7041461 Css 3compartmentss Human 95% 20.76 mg/L 31.36 mg/L 0.661989795918367 -DTXSID7041467 Css 3compartmentss Human 95% 56.78 mg/L 26.64 mg/L 2.13138138138138 -DTXSID7041540 Css 3compartmentss Human 95% 15.38 mg/L 9.409 mg/L 1.6346051652673 -DTXSID7041621 Css 3compartmentss Human 95% 2.002 mg/L 1.15 mg/L 1.74086956521739 -DTXSID7041623 Css 3compartmentss Human 95% 3.172 mg/L 1.764 mg/L 1.79818594104308 -DTXSID7041625 Css 3compartmentss Human 95% 8.603 mg/L 4.824 mg/L 1.78337479270315 -DTXSID7041627 Css 3compartmentss Human 95% 0.4107 mg/L 0.2609 mg/L 1.57416634725949 -DTXSID7041629 Css 3compartmentss Human 95% 2.92 mg/L 0.7343 mg/L 3.97657633119978 -DTXSID7041675 Css 3compartmentss Human 95% 4.962 mg/L 4.53 mg/L 1.0953642384106 -DTXSID7041708 Css 3compartmentss Human 95% 8.628 mg/L 4.466 mg/L 1.93193013882669 -DTXSID7041752 Css 3compartmentss Human 95% 0.7219 mg/L 0.4595 mg/L 1.57105549510337 -DTXSID7041756 Css 3compartmentss Human 95% 1.315 mg/L 0.7931 mg/L 1.6580506871769 -DTXSID7041883 Css 3compartmentss Human 95% 110 mg/L 60.66 mg/L 1.81338608638312 -DTXSID7041887 Css 3compartmentss Human 95% 0.402 mg/L 0.2516 mg/L 1.59777424483307 -DTXSID7041889 Css 3compartmentss Human 95% 1.662 mg/L 1.22 mg/L 1.36229508196721 -DTXSID7041910 Css 3compartmentss Human 95% 7.571 mg/L 2.716 mg/L 2.78755522827688 -DTXSID7041914 Css 3compartmentss Human 95% 0.3759 mg/L 0.2962 mg/L 1.26907494935854 -DTXSID7041916 Css 3compartmentss Human 95% 0.06909 mg/L 0.03954 mg/L 1.74734446130501 -DTXSID7041918 Css 3compartmentss Human 95% 4.919 mg/L 2.213 mg/L 2.22277451423407 -DTXSID7041964 Css 3compartmentss Human 95% 0.6384 mg/L 0.339 mg/L 1.88318584070796 -DTXSID7041966 Css 3compartmentss Human 95% 0.9743 mg/L 0.4135 mg/L 2.35622732769045 -DTXSID7042011 Css 3compartmentss Human 95% 41.13 mg/L 19.86 mg/L 2.07099697885196 -DTXSID7042019 Css 3compartmentss Human 95% 113.7 mg/L 59.64 mg/L 1.90643863179074 -DTXSID7042063 Css 3compartmentss Human 95% 0.7352 mg/L 0.3828 mg/L 1.92058516196447 -DTXSID7042065 Css 3compartmentss Human 95% 1525 mg/L 1.658 mg/L 919.78287092883 -DTXSID7042140 Css 3compartmentss Human 95% 0.5652 mg/L 0.3622 mg/L 1.56046383213694 -DTXSID7042146 Css 3compartmentss Human 95% 0.8175 mg/L 0.3004 mg/L 2.72137150466045 -DTXSID7042196 Css 3compartmentss Human 95% 7.282 mg/L 5.792 mg/L 1.25725138121547 -DTXSID7042198 Css 3compartmentss Human 95% 4.913 mg/L 3.014 mg/L 1.6300597213006 -DTXSID7042273 Css 3compartmentss Human 95% 5.589 mg/L 2.361 mg/L 2.36721728081321 -DTXSID7042279 Css 3compartmentss Human 95% 1.079 mg/L 0.6834 mg/L 1.57887035411179 -DTXSID7042352 Css 3compartmentss Human 95% 0.4236 mg/L 0.1252 mg/L 3.38338658146965 -DTXSID7042437 Css 3compartmentss Human 95% 2.101 mg/L 1.09 mg/L 1.92752293577982 -DTXSID7042514 Css 3compartmentss Human 95% 5.553 mg/L 3.628 mg/L 1.5305953693495 -DTXSID7043829 Css 3compartmentss Human 95% 0.05109 mg/L 0.03354 mg/L 1.52325581395349 -DTXSID7043873 Css 3compartmentss Human 95% 0.3122 mg/L 0.2572 mg/L 1.21384136858476 -DTXSID7043902 Css 3compartmentss Human 95% 1.644 mg/L 0.4284 mg/L 3.8375350140056 -DTXSID7043908 Css 3compartmentss Human 95% 0.06682 mg/L 0.04194 mg/L 1.5932284215546 -DTXSID7043950 Css 3compartmentss Human 95% 8.509 mg/L 5.214 mg/L 1.6319524357499 -DTXSID7043952 Css 3compartmentss Human 95% 30.46 mg/L 8.046 mg/L 3.7857320407656 -DTXSID7044130 Css 3compartmentss Human 95% 1.28 mg/L 0.7955 mg/L 1.60905091137649 -DTXSID7044132 Css 3compartmentss Human 95% 0.5558 mg/L 0.3436 mg/L 1.61757857974389 -DTXSID7044215 Css 3compartmentss Human 95% 2.649 mg/L 1.519 mg/L 1.74391046741277 -DTXSID7044217 Css 3compartmentss Human 95% 213.1 mg/L 118.2 mg/L 1.80287648054145 -DTXSID7044267 Css 3compartmentss Human 95% 60.16 mg/L 34.39 mg/L 1.74934574004071 -DTXSID7044340 Css 3compartmentss Human 95% 30.22 mg/L 16.3 mg/L 1.85398773006135 -DTXSID7044342 Css 3compartmentss Human 95% 1.205 mg/L 0.6607 mg/L 1.8238232177993 -DTXSID7044346 Css 3compartmentss Human 95% 0.001693 mg/L 0.001323 mg/L 1.27966742252457 -DTXSID7044390 Css 3compartmentss Human 95% 1.039 mg/L 0.6512 mg/L 1.59551597051597 -DTXSID7044396 Css 3compartmentss Human 95% 1.282 mg/L 0.7666 mg/L 1.67231933211584 -DTXSID7044398 Css 3compartmentss Human 95% 0.922 mg/L 0.4209 mg/L 2.19054407222618 -DTXSID7044421 Css 3compartmentss Human 95% 1.09 mg/L 0.4781 mg/L 2.27985777034093 -DTXSID7044425 Css 3compartmentss Human 95% 8.736 mg/L 5.374 mg/L 1.62560476367696 -DTXSID7044427 Css 3compartmentss Human 95% 1.397 mg/L 1.02 mg/L 1.36960784313725 -DTXSID7044429 Css 3compartmentss Human 95% 35.68 mg/L 24.54 mg/L 1.45395273023635 -DTXSID7044471 Css 3compartmentss Human 95% 0.1192 mg/L 0.08139 mg/L 1.46455338493672 -DTXSID7044473 Css 3compartmentss Human 95% 29.63 mg/L 17.72 mg/L 1.67212189616253 -DTXSID7044479 Css 3compartmentss Human 95% 0.8092 mg/L 0.4249 mg/L 1.90444810543657 -DTXSID7044500 Css 3compartmentss Human 95% 106.1 mg/L 0.5373 mg/L 197.468825609529 -DTXSID7044502 Css 3compartmentss Human 95% 0.05032 mg/L 0.0308 mg/L 1.63376623376623 -DTXSID7044504 Css 3compartmentss Human 95% 5.602 mg/L 3.821 mg/L 1.46610834859984 -DTXSID7044508 Css 3compartmentss Human 95% 6.885 mg/L 4.286 mg/L 1.60639290713952 -DTXSID7044552 Css 3compartmentss Human 95% 6.578 mg/L 4.713 mg/L 1.39571398260132 -DTXSID7044554 Css 3compartmentss Human 95% 77.71 mg/L 42.26 mg/L 1.83885470894463 -DTXSID7044631 Css 3compartmentss Human 95% 1.477 mg/L 0.9241 mg/L 1.59831187100963 -DTXSID7044633 Css 3compartmentss Human 95% 11.49 mg/L 6.338 mg/L 1.81287472388766 -DTXSID7044635 Css 3compartmentss Human 95% 3.175 mg/L 1.824 mg/L 1.7406798245614 -DTXSID7044681 Css 3compartmentss Human 95% 0.789 mg/L 0.03776 mg/L 20.8951271186441 -DTXSID7044689 Css 3compartmentss Human 95% 1.459 mg/L 0.8461 mg/L 1.72438246070204 -DTXSID7044710 Css 3compartmentss Human 95% 3.25 mg/L 1.887 mg/L 1.72231054583996 -DTXSID7044714 Css 3compartmentss Human 95% 4.016 mg/L 2.335 mg/L 1.71991434689508 -DTXSID7044716 Css 3compartmentss Human 95% 0.9812 mg/L 0.7642 mg/L 1.28395707929861 -DTXSID7044718 Css 3compartmentss Human 95% 12.15 mg/L 6.302 mg/L 1.92795937797525 -DTXSID7044762 Css 3compartmentss Human 95% 2.334 mg/L 1.013 mg/L 2.3040473840079 -DTXSID7044768 Css 3compartmentss Human 95% 4.462 mg/L 2.703 mg/L 1.65075841657418 -DTXSID7044841 Css 3compartmentss Human 95% 3076 mg/L 6429 mg/L 0.478456991756105 -DTXSID7044843 Css 3compartmentss Human 95% 924.1 mg/L 39.37 mg/L 23.4721869443739 -DTXSID7044845 Css 3compartmentss Human 95% 0.9746 mg/L 0.581 mg/L 1.67745266781411 -DTXSID7044847 Css 3compartmentss Human 95% 0.0325 mg/L 0.02346 mg/L 1.38533674339301 -DTXSID7044849 Css 3compartmentss Human 95% 3.862 mg/L 2.474 mg/L 1.56103476151981 -DTXSID7044893 Css 3compartmentss Human 95% 172.6 mg/L 14.8 mg/L 11.6621621621622 -DTXSID7044895 Css 3compartmentss Human 95% 0.6811 mg/L 0.3535 mg/L 1.92673267326733 -DTXSID7044897 Css 3compartmentss Human 95% 4.825 mg/L 3.271 mg/L 1.47508407214919 -DTXSID7044899 Css 3compartmentss Human 95% 0.2086 mg/L 0.133 mg/L 1.56842105263158 -DTXSID7044922 Css 3compartmentss Human 95% 1.834 mg/L 1.345 mg/L 1.3635687732342 -DTXSID7044926 Css 3compartmentss Human 95% 0.05245 mg/L 0.01273 mg/L 4.12018853102906 -DTXSID7044928 Css 3compartmentss Human 95% 0.03783 mg/L 0.02939 mg/L 1.28717250765567 -DTXSID7044970 Css 3compartmentss Human 95% 16.36 mg/L 13.36 mg/L 1.22455089820359 -DTXSID7044972 Css 3compartmentss Human 95% 202.6 mg/L 6.954 mg/L 29.1343111878056 -DTXSID7044974 Css 3compartmentss Human 95% 2.882 mg/L 1.791 mg/L 1.60915689558906 -DTXSID7044976 Css 3compartmentss Human 95% 0.7794 mg/L 0.5181 mg/L 1.50434279096699 -DTXSID7044978 Css 3compartmentss Human 95% 0.9949 mg/L 6.4e-08 mg/L 15545312.5 -DTXSID7045029 Css 3compartmentss Human 95% 10.98 mg/L 1.903 mg/L 5.76983709931687 -DTXSID7045079 Css 3compartmentss Human 95% 7.122 mg/L 4.477 mg/L 1.59079740897923 -DTXSID7045106 Css 3compartmentss Human 95% 21.97 mg/L 12.59 mg/L 1.7450357426529 -DTXSID7045150 Css 3compartmentss Human 95% 11.66 mg/L 3.724 mg/L 3.13104189044039 -DTXSID7045152 Css 3compartmentss Human 95% 10.08 mg/L 0.02019 mg/L 499.25705794948 -DTXSID7045158 Css 3compartmentss Human 95% 1.125 mg/L 0.7836 mg/L 1.43568147013783 -DTXSID7045281 Css 3compartmentss Human 95% 6.544 mg/L 3.611 mg/L 1.81224037662697 -DTXSID7045287 Css 3compartmentss Human 95% 8.642 mg/L 4.781 mg/L 1.80757163773269 -DTXSID7045310 Css 3compartmentss Human 95% 1.705 mg/L 0.7504 mg/L 2.27212153518124 -DTXSID7045312 Css 3compartmentss Human 95% 1.87 mg/L 1.219 mg/L 1.53404429860541 -DTXSID7045316 Css 3compartmentss Human 95% 0.4927 mg/L 0.3343 mg/L 1.47382590487586 -DTXSID7045318 Css 3compartmentss Human 95% 8.094 mg/L 4.937 mg/L 1.63945716021876 -DTXSID7045360 Css 3compartmentss Human 95% 8.9 mg/L 2.946 mg/L 3.02104548540394 -DTXSID7045364 Css 3compartmentss Human 95% 2.047 mg/L 1.076 mg/L 1.90241635687732 -DTXSID7045366 Css 3compartmentss Human 95% 3.171 mg/L 1.955 mg/L 1.62199488491049 -DTXSID7045368 Css 3compartmentss Human 95% 3.183 mg/L 2.059 mg/L 1.54589606605148 -DTXSID7045441 Css 3compartmentss Human 95% 4.09 mg/L 2.158 mg/L 1.8952734012975 -DTXSID7045443 Css 3compartmentss Human 95% 0.5406 mg/L 0.3025 mg/L 1.78710743801653 -DTXSID7045447 Css 3compartmentss Human 95% 15.99 mg/L 2.953 mg/L 5.4148323738571 -DTXSID7045493 Css 3compartmentss Human 95% 1.736 mg/L 1.168 mg/L 1.48630136986301 -DTXSID7045497 Css 3compartmentss Human 95% 18.23 mg/L 8.337 mg/L 2.18663787933309 -DTXSID7045522 Css 3compartmentss Human 95% 31.5 mg/L 16.66 mg/L 1.89075630252101 -DTXSID7045526 Css 3compartmentss Human 95% 1.516 mg/L 0.9962 mg/L 1.52178277454326 -DTXSID7045570 Css 3compartmentss Human 95% 39.6 mg/L 16.89 mg/L 2.34458259325044 -DTXSID7045572 Css 3compartmentss Human 95% 7.264 mg/L 3.124 mg/L 2.32522407170294 -DTXSID7045574 Css 3compartmentss Human 95% 9.316 mg/L 5.636 mg/L 1.65294535131299 -DTXSID7045576 Css 3compartmentss Human 95% 139.1 mg/L 74.9 mg/L 1.85714285714286 -DTXSID7045578 Css 3compartmentss Human 95% 4.396 mg/L 2.982 mg/L 1.47417840375587 -DTXSID7045601 Css 3compartmentss Human 95% 0.6551 mg/L 0.0006838 mg/L 958.028663351857 -DTXSID7045603 Css 3compartmentss Human 95% 6.325 mg/L 3.943 mg/L 1.60410854679178 -DTXSID7045605 Css 3compartmentss Human 95% 0.4299 mg/L 0.2658 mg/L 1.61738148984199 -DTXSID7045607 Css 3compartmentss Human 95% 38.2 mg/L 16.53 mg/L 2.31094978826376 -DTXSID7045651 Css 3compartmentss Human 95% 2.736 mg/L 1.914 mg/L 1.4294670846395 -DTXSID7045653 Css 3compartmentss Human 95% 1.663 mg/L 0.7385 mg/L 2.25186188219364 -DTXSID7045655 Css 3compartmentss Human 95% 52.84 mg/L 30.09 mg/L 1.75606513791957 -DTXSID7045659 Css 3compartmentss Human 95% 0.6107 mg/L 0.5472 mg/L 1.11604532163743 -DTXSID7045780 Css 3compartmentss Human 95% 5.042 mg/L 3.322 mg/L 1.51776038531005 -DTXSID7045782 Css 3compartmentss Human 95% 0.02474 mg/L 0.0202 mg/L 1.22475247524752 -DTXSID7045786 Css 3compartmentss Human 95% 9.998 mg/L 5.446 mg/L 1.83584282041866 -DTXSID7045788 Css 3compartmentss Human 95% 0.3297 mg/L 0.2111 mg/L 1.56181904310753 -DTXSID7045811 Css 3compartmentss Human 95% 0.2591 mg/L 0.001811 mg/L 143.070127001657 -DTXSID7045813 Css 3compartmentss Human 95% 9.637 mg/L 5.433 mg/L 1.7737898030554 -DTXSID7045815 Css 3compartmentss Human 95% 4.787 mg/L 2.843 mg/L 1.68378473443546 -DTXSID7045861 Css 3compartmentss Human 95% 0.8598 mg/L 0.5396 mg/L 1.59340252038547 -DTXSID7045863 Css 3compartmentss Human 95% 23.4 mg/L 6.283 mg/L 3.72433550851504 -DTXSID7045865 Css 3compartmentss Human 95% 21.18 mg/L 8.918 mg/L 2.3749719668087 -DTXSID7045867 Css 3compartmentss Human 95% 28.01 mg/L 4.059 mg/L 6.90071446169007 -DTXSID7045940 Css 3compartmentss Human 95% 4.073 mg/L 2.593 mg/L 1.57076745082916 -DTXSID7045942 Css 3compartmentss Human 95% 8667 mg/L 8972 mg/L 0.966005349977708 -DTXSID7045944 Css 3compartmentss Human 95% 0.8678 mg/L 0.6484 mg/L 1.33837137569402 -DTXSID7045946 Css 3compartmentss Human 95% 17.72 mg/L 12.76 mg/L 1.38871473354232 -DTXSID7045948 Css 3compartmentss Human 95% 0.6695 mg/L 0.4342 mg/L 1.54191616766467 -DTXSID7045992 Css 3compartmentss Human 95% 0.4245 mg/L 0.3187 mg/L 1.33197364292438 -DTXSID7045998 Css 3compartmentss Human 95% 8.053 mg/L 4.198 mg/L 1.9182944259171 -DTXSID7046041 Css 3compartmentss Human 95% 0.9966 mg/L 0.6878 mg/L 1.44896772317534 -DTXSID7046045 Css 3compartmentss Human 95% 1.116 mg/L 0.6723 mg/L 1.65997322623829 -DTXSID7046047 Css 3compartmentss Human 95% 3.284 mg/L 1.966 mg/L 1.67039674465921 -DTXSID7046091 Css 3compartmentss Human 95% 4.589 mg/L 1.63 mg/L 2.81533742331288 -DTXSID7046093 Css 3compartmentss Human 95% 6.079 mg/L 3.56 mg/L 1.70758426966292 -DTXSID7046095 Css 3compartmentss Human 95% 0.02489 mg/L 0.01393 mg/L 1.78679109834889 -DTXSID7046097 Css 3compartmentss Human 95% 5.704 mg/L 3.593 mg/L 1.58753131088227 -DTXSID7046099 Css 3compartmentss Human 95% 0.1393 mg/L 0.0865 mg/L 1.61040462427746 -DTXSID7046120 Css 3compartmentss Human 95% 3.137 mg/L 1.164 mg/L 2.69501718213058 -DTXSID7046122 Css 3compartmentss Human 95% 219.1 mg/L 123 mg/L 1.78130081300813 -DTXSID7046126 Css 3compartmentss Human 95% 3.221 mg/L 2.149 mg/L 1.49883666821778 -DTXSID7046128 Css 3compartmentss Human 95% 1.398 mg/L 0.841 mg/L 1.66230677764566 -DTXSID7046170 Css 3compartmentss Human 95% 7.208 mg/L 0.5146 mg/L 14.0069957248348 -DTXSID7046172 Css 3compartmentss Human 95% 7.468 mg/L 4.681 mg/L 1.59538560136723 -DTXSID7046174 Css 3compartmentss Human 95% 1.682 mg/L 0.9738 mg/L 1.72725405627439 -DTXSID7046176 Css 3compartmentss Human 95% 1.286 mg/L 0.5919 mg/L 2.17266430140226 -DTXSID7046178 Css 3compartmentss Human 95% 1.261 mg/L 0.6211 mg/L 2.03026887779746 -DTXSID7046201 Css 3compartmentss Human 95% 0.6618 mg/L 0.3723 mg/L 1.77759871071716 -DTXSID7046205 Css 3compartmentss Human 95% 4.662 mg/L 0.02281 mg/L 204.384042086804 -DTXSID7046207 Css 3compartmentss Human 95% 8.814 mg/L 3.818 mg/L 2.30853850183342 -DTXSID7046251 Css 3compartmentss Human 95% 6.693 mg/L 4.095 mg/L 1.63443223443223 -DTXSID7046253 Css 3compartmentss Human 95% 3.366 mg/L 1.635 mg/L 2.05871559633028 -DTXSID7046257 Css 3compartmentss Human 95% 4.225 mg/L 2.54 mg/L 1.66338582677165 -DTXSID7046259 Css 3compartmentss Human 95% 1.045 mg/L 0.6323 mg/L 1.65269650482366 -DTXSID7046384 Css 3compartmentss Human 95% 0.2909 mg/L 0.1898 mg/L 1.53266596417281 -DTXSID7046386 Css 3compartmentss Human 95% 11.42 mg/L 4.322 mg/L 2.64229523368811 -DTXSID7046388 Css 3compartmentss Human 95% 4.581 mg/L 2.948 mg/L 1.55393487109905 -DTXSID7046411 Css 3compartmentss Human 95% 6.828 mg/L 5.927 mg/L 1.15201619706428 -DTXSID7046413 Css 3compartmentss Human 95% 0.2389 mg/L 0.1545 mg/L 1.5462783171521 -DTXSID7046415 Css 3compartmentss Human 95% 0.179 mg/L 0.04483 mg/L 3.99286192281954 -DTXSID7046417 Css 3compartmentss Human 95% 4.517 mg/L 2.353 mg/L 1.9196770080748 -DTXSID7046419 Css 3compartmentss Human 95% 1.793 mg/L 1.168 mg/L 1.53510273972603 -DTXSID7046461 Css 3compartmentss Human 95% 0.4708 mg/L 0.1919 mg/L 2.45336112558624 -DTXSID7046463 Css 3compartmentss Human 95% 1.387 mg/L 0.7773 mg/L 1.78438183455551 -DTXSID7046465 Css 3compartmentss Human 95% 3.915 mg/L 2.424 mg/L 1.61509900990099 -DTXSID7046467 Css 3compartmentss Human 95% 0.2444 mg/L 0.1487 mg/L 1.64357767316745 -DTXSID7046540 Css 3compartmentss Human 95% 5.756 mg/L 3.628 mg/L 1.58654906284454 -DTXSID7046542 Css 3compartmentss Human 95% 2.66 mg/L 1.535 mg/L 1.7328990228013 -DTXSID7046592 Css 3compartmentss Human 95% 7.329 mg/L 5.158 mg/L 1.42089957347809 -DTXSID7046594 Css 3compartmentss Human 95% 7.654 mg/L 4.779 mg/L 1.60159029085583 -DTXSID7046621 Css 3compartmentss Human 95% 0.8018 mg/L 0.3623 mg/L 2.21308308032018 -DTXSID7046623 Css 3compartmentss Human 95% 10.29 mg/L 6.057 mg/L 1.6988608221892 -DTXSID7046627 Css 3compartmentss Human 95% 44.16 mg/L 22.45 mg/L 1.96703786191537 -DTXSID7046673 Css 3compartmentss Human 95% 6.143 mg/L 4.394 mg/L 1.39804278561675 -DTXSID7046675 Css 3compartmentss Human 95% 0.5994 mg/L 0.02627 mg/L 22.8169014084507 -DTXSID7046677 Css 3compartmentss Human 95% 0.1662 mg/L 0.09958 mg/L 1.6690098413336 -DTXSID7046700 Css 3compartmentss Human 95% 0.02039 mg/L 0 mg/L Inf -DTXSID7046702 Css 3compartmentss Human 95% 12.53 mg/L 7.61 mg/L 1.64651773981603 -DTXSID7046706 Css 3compartmentss Human 95% 5.943 mg/L 3.744 mg/L 1.58733974358974 -DTXSID7046708 Css 3compartmentss Human 95% 0.09129 mg/L 0.04573 mg/L 1.99628252788104 -DTXSID7046750 Css 3compartmentss Human 95% 7.853 mg/L 4.89 mg/L 1.60593047034765 -DTXSID7046752 Css 3compartmentss Human 95% 7.881 mg/L 4.266 mg/L 1.84739803094233 -DTXSID7046754 Css 3compartmentss Human 95% 0.1773 mg/L 0 mg/L Inf -DTXSID7046756 Css 3compartmentss Human 95% 0.8044 mg/L 0.4678 mg/L 1.71953826421548 -DTXSID7046758 Css 3compartmentss Human 95% 1.573 mg/L 1.224 mg/L 1.28513071895425 -DTXSID7046831 Css 3compartmentss Human 95% 7.122 mg/L 4.495 mg/L 1.58442714126808 -DTXSID7046835 Css 3compartmentss Human 95% 1.035 mg/L 0.01022 mg/L 101.272015655577 -DTXSID7046837 Css 3compartmentss Human 95% 0.09191 mg/L 8e-09 mg/L 11488750 -DTXSID7046839 Css 3compartmentss Human 95% 2.22 mg/L 1.331 mg/L 1.6679188580015 -DTXSID7046881 Css 3compartmentss Human 95% 40.38 mg/L 22.17 mg/L 1.8213802435724 -DTXSID7046883 Css 3compartmentss Human 95% 4.346 mg/L 4.28 mg/L 1.01542056074766 -DTXSID7046885 Css 3compartmentss Human 95% 3.307 mg/L 1.924 mg/L 1.71881496881497 -DTXSID7046887 Css 3compartmentss Human 95% 0.8937 mg/L 0.5608 mg/L 1.59361626248217 -DTXSID7046889 Css 3compartmentss Human 95% 7.747 mg/L 3.39 mg/L 2.28525073746313 -DTXSID7046910 Css 3compartmentss Human 95% 32.1 mg/L 17.34 mg/L 1.85121107266436 -DTXSID7046912 Css 3compartmentss Human 95% 12.31 mg/L 12.09 mg/L 1.01819685690653 -DTXSID7046914 Css 3compartmentss Human 95% 39.25 mg/L 25.47 mg/L 1.54102866117 -DTXSID7046966 Css 3compartmentss Human 95% 1.164 mg/L 0.7699 mg/L 1.5118846603455 -DTXSID7047065 Css 3compartmentss Human 95% 0.04877 mg/L 0.02995 mg/L 1.62838063439065 -DTXSID7047144 Css 3compartmentss Human 95% 0.4279 mg/L 0.2381 mg/L 1.79714405711886 -DTXSID7047146 Css 3compartmentss Human 95% 5.673 mg/L 0.01907 mg/L 297.482957524908 -DTXSID7047190 Css 3compartmentss Human 95% 60.57 mg/L 80.45 mg/L 0.75288999378496 -DTXSID7047192 Css 3compartmentss Human 95% 1.248 mg/L 1.192 mg/L 1.04697986577181 -DTXSID7047196 Css 3compartmentss Human 95% 2.676 mg/L 2.03 mg/L 1.31822660098522 -DTXSID7047271 Css 3compartmentss Human 95% 7.327 mg/L 0.9373 mg/L 7.81713432198869 -DTXSID7047277 Css 3compartmentss Human 95% 12.33 mg/L 1.851 mg/L 6.6612641815235 -DTXSID7047279 Css 3compartmentss Human 95% 2.537 mg/L 0.0003549 mg/L 7148.49253310792 -DTXSID7047304 Css 3compartmentss Human 95% 104.4 mg/L 57.67 mg/L 1.81029998265996 -DTXSID7047306 Css 3compartmentss Human 95% 255.8 mg/L 150.3 mg/L 1.70192947438456 -DTXSID7047308 Css 3compartmentss Human 95% 70.72 mg/L 25.44 mg/L 2.77987421383648 -DTXSID7047354 Css 3compartmentss Human 95% 9.241 mg/L 2.56 mg/L 3.609765625 -DTXSID7047356 Css 3compartmentss Human 95% 1.273 mg/L 0.8997 mg/L 1.41491608313882 -DTXSID7047358 Css 3compartmentss Human 95% 1.859 mg/L 1.083 mg/L 1.71652816251154 -DTXSID7047433 Css 3compartmentss Human 95% 7.539 mg/L 3.216 mg/L 2.34421641791045 -DTXSID7047435 Css 3compartmentss Human 95% 4.662 mg/L 2.662 mg/L 1.75131480090158 -DTXSID7047437 Css 3compartmentss Human 95% 31.17 mg/L 47.62 mg/L 0.654556908861823 -DTXSID7047487 Css 3compartmentss Human 95% 4.433 mg/L 2.475 mg/L 1.79111111111111 -DTXSID7047512 Css 3compartmentss Human 95% 6.927 mg/L 4.363 mg/L 1.58766903506761 -DTXSID7047518 Css 3compartmentss Human 95% 1.011 mg/L 0.7326 mg/L 1.38001638001638 -DTXSID7047568 Css 3compartmentss Human 95% 2.739 mg/L 2.075 mg/L 1.32 -DTXSID7047641 Css 3compartmentss Human 95% 406.6 mg/L 0.5517 mg/L 736.994743520029 -DTXSID7047643 Css 3compartmentss Human 95% 9.345 mg/L 8.412 mg/L 1.11091298145506 -DTXSID7047645 Css 3compartmentss Human 95% 0.03324 mg/L 0.02207 mg/L 1.50611690077028 -DTXSID7047647 Css 3compartmentss Human 95% 9.029 mg/L 1.04 mg/L 8.68173076923077 -DTXSID7047649 Css 3compartmentss Human 95% 0.05108 mg/L 0.03367 mg/L 1.51707751707752 -DTXSID7047693 Css 3compartmentss Human 95% 5.216 mg/L 3.699 mg/L 1.41011084076778 -DTXSID7047697 Css 3compartmentss Human 95% 0.9789 mg/L 0.3527 mg/L 2.77544655514602 -DTXSID7047726 Css 3compartmentss Human 95% 1.118 mg/L 0.704 mg/L 1.58806818181818 -DTXSID7047772 Css 3compartmentss Human 95% 2.484 mg/L 0.8517 mg/L 2.91651990137372 -DTXSID7047774 Css 3compartmentss Human 95% 0.2883 mg/L 0.2188 mg/L 1.31764168190128 -DTXSID7047776 Css 3compartmentss Human 95% 0.1064 mg/L 0.07722 mg/L 1.37788137788138 -DTXSID7047778 Css 3compartmentss Human 95% 1.803 mg/L 0.1651 mg/L 10.9206541490006 -DTXSID7047801 Css 3compartmentss Human 95% 7.552 mg/L 4.622 mg/L 1.63392470791865 -DTXSID7047803 Css 3compartmentss Human 95% 0.5109 mg/L 0.335 mg/L 1.52507462686567 -DTXSID7047807 Css 3compartmentss Human 95% 0.292 mg/L 0.1644 mg/L 1.77615571776156 -DTXSID7047851 Css 3compartmentss Human 95% 0.7206 mg/L 0.4137 mg/L 1.74184191443075 -DTXSID7047853 Css 3compartmentss Human 95% 1.008 mg/L 0.3664 mg/L 2.75109170305677 -DTXSID7047857 Css 3compartmentss Human 95% 0.4816 mg/L 0.3292 mg/L 1.46294046172539 -DTXSID7047859 Css 3compartmentss Human 95% 1.897 mg/L 0.9133 mg/L 2.07708310522282 -DTXSID7047930 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID7048168 Css 3compartmentss Human 95% 13.76 mg/L 6.402 mg/L 2.14932833489534 -DTXSID7048291 Css 3compartmentss Human 95% 679.8 mg/L 364.1 mg/L 1.86706948640483 -DTXSID7048580 Css 3compartmentss Human 95% 0.1031 mg/L 0.058 mg/L 1.77758620689655 -DTXSID7048582 Css 3compartmentss Human 95% 0.3965 mg/L 0.2353 mg/L 1.68508287292818 -DTXSID7048584 Css 3compartmentss Human 95% NA mg/L NA NA NA -DTXSID7048586 Css 3compartmentss Human 95% 0.04218 mg/L 0.0009997 mg/L 42.1926577973392 -DTXSID7048588 Css 3compartmentss Human 95% 4.918 mg/L 5.299 mg/L 0.928099641441781 -DTXSID7048611 Css 3compartmentss Human 95% 3.911 mg/L 3.221 mg/L 1.21421918658802 -DTXSID7048613 Css 3compartmentss Human 95% 34.56 mg/L 20.62 mg/L 1.67604267701261 -DTXSID7048615 Css 3compartmentss Human 95% 0.3026 mg/L 0.2512 mg/L 1.2046178343949 -DTXSID7048617 Css 3compartmentss Human 95% 55.75 mg/L 56.99 mg/L 0.978241796806457 -DTXSID7048619 Css 3compartmentss Human 95% 46.4 mg/L 57.85 mg/L 0.802074330164218 -DTXSID7048661 Css 3compartmentss Human 95% 6.709 mg/L 3.818 mg/L 1.75720272393924 -DTXSID7048663 Css 3compartmentss Human 95% 7.24 mg/L 3.931 mg/L 1.84177054184686 -DTXSID7048665 Css 3compartmentss Human 95% 30.93 mg/L 18.28 mg/L 1.69201312910284 -DTXSID7048667 Css 3compartmentss Human 95% 0.2835 mg/L 0.2597 mg/L 1.09164420485175 -DTXSID7048669 Css 3compartmentss Human 95% 2.868 mg/L 1.753 mg/L 1.63605248146035 -DTXSID7048740 Css 3compartmentss Human 95% 6.143 mg/L 3.943 mg/L 1.5579507988841 -DTXSID7048742 Css 3compartmentss Human 95% 7.092 mg/L 4.156 mg/L 1.70644850818094 -DTXSID7048746 Css 3compartmentss Human 95% 60.61 mg/L 26.42 mg/L 2.29409538228615 -DTXSID7048748 Css 3compartmentss Human 95% 0.1217 mg/L 0.09812 mg/L 1.24031797798614 -DTXSID7048790 Css 3compartmentss Human 95% 10.21 mg/L 1.112 mg/L 9.18165467625899 -DTXSID7048792 Css 3compartmentss Human 95% 0.1534 mg/L 0.09164 mg/L 1.67394151025753 -DTXSID7048794 Css 3compartmentss Human 95% 13.5 mg/L 6.156 mg/L 2.19298245614035 -DTXSID7048796 Css 3compartmentss Human 95% 26.27 mg/L 11.52 mg/L 2.28038194444444 -DTXSID7048798 Css 3compartmentss Human 95% 0.0197 mg/L 1e-09 mg/L 19700000 -DTXSID7048821 Css 3compartmentss Human 95% 10.02 mg/L 6.092 mg/L 1.64478003939593 -DTXSID7048823 Css 3compartmentss Human 95% 5698 mg/L 9739 mg/L 0.585070335763425 -DTXSID7048825 Css 3compartmentss Human 95% 0.205 mg/L 0.1107 mg/L 1.85185185185185 -DTXSID7048827 Css 3compartmentss Human 95% 335.6 mg/L 122.3 mg/L 2.74407195421096 -DTXSID7048829 Css 3compartmentss Human 95% 0.7063 mg/L 0.4712 mg/L 1.49893887945671 -DTXSID7048871 Css 3compartmentss Human 95% 0.6371 mg/L 0.3187 mg/L 1.99905867587072 -DTXSID7048873 Css 3compartmentss Human 95% 11.41 mg/L 8.352 mg/L 1.3661398467433 -DTXSID7048875 Css 3compartmentss Human 95% 7.066 mg/L 3.451 mg/L 2.04752245725877 -DTXSID7048877 Css 3compartmentss Human 95% 2.096 mg/L 0.601 mg/L 3.48752079866889 -DTXSID7048879 Css 3compartmentss Human 95% 0.005636 mg/L 0.004483 mg/L 1.25719384340843 -DTXSID7048900 Css 3compartmentss Human 95% 0.2993 mg/L 0.04811 mg/L 6.22115984202868 -DTXSID7048902 Css 3compartmentss Human 95% 0.5565 mg/L 0.431 mg/L 1.29118329466357 -DTXSID7048904 Css 3compartmentss Human 95% 0.3727 mg/L 0.2667 mg/L 1.39745031871016 -DTXSID7048906 Css 3compartmentss Human 95% 1.732 mg/L 1.186 mg/L 1.46037099494098 -DTXSID7048908 Css 3compartmentss Human 95% 0.4435 mg/L 0.3454 mg/L 1.28401852924146 -DTXSID7048950 Css 3compartmentss Human 95% 14.64 mg/L 7.539 mg/L 1.94190210903303 -DTXSID7048952 Css 3compartmentss Human 95% 0.1154 mg/L 0.08676 mg/L 1.33010603964961 -DTXSID7048954 Css 3compartmentss Human 95% 8.997 mg/L 5.704 mg/L 1.5773141654979 -DTXSID7048956 Css 3compartmentss Human 95% 0.2126 mg/L 0.1621 mg/L 1.31153608883405 -DTXSID7048958 Css 3compartmentss Human 95% 20.34 mg/L 8.383 mg/L 2.42633901944411 -DTXSID7049001 Css 3compartmentss Human 95% 0.08216 mg/L 0.05722 mg/L 1.43586158685774 -DTXSID7049003 Css 3compartmentss Human 95% 0.2182 mg/L 0.1588 mg/L 1.37405541561713 -DTXSID7049005 Css 3compartmentss Human 95% 22.99 mg/L 11.42 mg/L 2.01313485113835 -DTXSID7049007 Css 3compartmentss Human 95% 11.67 mg/L 6.524 mg/L 1.78877988963826 -DTXSID7049009 Css 3compartmentss Human 95% 28.64 mg/L 47.88 mg/L 0.598162071846282 -DTXSID7049051 Css 3compartmentss Human 95% 4.807 mg/L 1.197 mg/L 4.01587301587302 -DTXSID7049053 Css 3compartmentss Human 95% 0.04943 mg/L 0.03755 mg/L 1.31637816245007 -DTXSID7049055 Css 3compartmentss Human 95% 1.629 mg/L 0.9303 mg/L 1.75104804901645 -DTXSID7049057 Css 3compartmentss Human 95% 0.4645 mg/L 0.3346 mg/L 1.38822474596533 -DTXSID7049059 Css 3compartmentss Human 95% 0.3896 mg/L 0.2499 mg/L 1.55902360944378 -DTXSID7049211 Css 3compartmentss Human 95% 9.505 mg/L 4.945 mg/L 1.9221435793731 -DTXSID7049213 Css 3compartmentss Human 95% 16.8 mg/L 11.01 mg/L 1.52588555858311 -DTXSID7049215 Css 3compartmentss Human 95% 5.345 mg/L 3.852 mg/L 1.38759086188993 -DTXSID7049261 Css 3compartmentss Human 95% 2.734 mg/L 1.89 mg/L 1.44656084656085 -DTXSID7049265 Css 3compartmentss Human 95% 0.3968 mg/L 0.258 mg/L 1.53798449612403 -DTXSID7049340 Css 3compartmentss Human 95% 5.472 mg/L 0.006608 mg/L 828.087167070218 -DTXSID7049344 Css 3compartmentss Human 95% 6.991 mg/L 5.19 mg/L 1.34701348747591 -DTXSID7049346 Css 3compartmentss Human 95% 13.03 mg/L 8.96 mg/L 1.45424107142857 -DTXSID7049392 Css 3compartmentss Human 95% 4.743 mg/L 4.822 mg/L 0.983616756532559 -DTXSID7049394 Css 3compartmentss Human 95% 1.894 mg/L 1.544 mg/L 1.22668393782383 -DTXSID7049398 Css 3compartmentss Human 95% 9.107 mg/L 8.453 mg/L 1.07736898142671 -DTXSID7049423 Css 3compartmentss Human 95% 0.3487 mg/L 0.2243 mg/L 1.55461435577352 -DTXSID7049425 Css 3compartmentss Human 95% 5.754 mg/L 3.414 mg/L 1.68541300527241 -DTXSID7049427 Css 3compartmentss Human 95% 143.8 mg/L 63.08 mg/L 2.27964489537096 -DTXSID7049429 Css 3compartmentss Human 95% 4.031 mg/L 2.615 mg/L 1.5414913957935 -DTXSID7051474 Css 3compartmentss Human 95% 0.2964 mg/L 0.1851 mg/L 1.60129659643436 -DTXSID7051557 Css 3compartmentss Human 95% 1.81 mg/L 1.381 mg/L 1.31064446053584 -DTXSID7051715 Css 3compartmentss Human 95% 0.2896 mg/L 0.2203 mg/L 1.3145710394916 -DTXSID7052288 Css 3compartmentss Human 95% 6.273 mg/L 4.212 mg/L 1.48931623931624 -DTXSID7052319 Css 3compartmentss Human 95% 1.218 mg/L 0.8074 mg/L 1.50854594996284 -DTXSID7052446 Css 3compartmentss Human 95% 1.433 mg/L 0.9219 mg/L 1.55439852478577 -DTXSID7052529 Css 3compartmentss Human 95% 0.6926 mg/L 0.4772 mg/L 1.45138306789606 -DTXSID7052571 Css 3compartmentss Human 95% 9.829 mg/L 6.478 mg/L 1.51728928681692 -DTXSID7052573 Css 3compartmentss Human 95% 0.947 mg/L 0.8216 mg/L 1.15262901655307 -DTXSID7052577 Css 3compartmentss Human 95% 7.199 mg/L 4.638 mg/L 1.55217766278568 -DTXSID7052602 Css 3compartmentss Human 95% 9.525 mg/L 6.854 mg/L 1.38969944557922 -DTXSID7052654 Css 3compartmentss Human 95% 1.913 mg/L 1.39 mg/L 1.37625899280576 -DTXSID7052860 Css 3compartmentss Human 95% 0.8161 mg/L 0.4433 mg/L 1.84096548612678 -DTXSID7052866 Css 3compartmentss Human 95% 3.175 mg/L 3.623e-06 mg/L 876345.569969638 -DTXSID7057602 Css 3compartmentss Human 95% 0.4236 mg/L 0.2844 mg/L 1.48945147679325 -DTXSID7057604 Css 3compartmentss Human 95% 2.878 mg/L 1.884 mg/L 1.5276008492569 -DTXSID7057606 Css 3compartmentss Human 95% 4.579 mg/L 3.051 mg/L 1.50081940347427 -DTXSID7057608 Css 3compartmentss Human 95% 1.399 mg/L 0.8911 mg/L 1.56996970037033 -DTXSID7057650 Css 3compartmentss Human 95% 1.011 mg/L 0.6837 mg/L 1.47871873628785 -DTXSID7057652 Css 3compartmentss Human 95% 0.3725 mg/L 0.157 mg/L 2.37261146496815 -DTXSID7057654 Css 3compartmentss Human 95% 1.191 mg/L 0.6515 mg/L 1.82808902532617 -DTXSID7057656 Css 3compartmentss Human 95% 5.589 mg/L 2.308 mg/L 2.42157712305026 -DTXSID7057658 Css 3compartmentss Human 95% 12.7 mg/L 2.33 mg/L 5.45064377682403 -DTXSID7057731 Css 3compartmentss Human 95% 2.881 mg/L 2.081 mg/L 1.3844305622297 -DTXSID7057733 Css 3compartmentss Human 95% 2.472 mg/L 1.825 mg/L 1.35452054794521 -DTXSID7057735 Css 3compartmentss Human 95% 0.5085 mg/L 0.3321 mg/L 1.53116531165312 -DTXSID7057737 Css 3compartmentss Human 95% 3.473 mg/L 2.226 mg/L 1.56019766397125 -DTXSID7057739 Css 3compartmentss Human 95% 0.2414 mg/L 0.1528 mg/L 1.57984293193717 -DTXSID7057781 Css 3compartmentss Human 95% 3.118 mg/L 2.267 mg/L 1.37538597265108 -DTXSID7057783 Css 3compartmentss Human 95% 5.943 mg/L 4.151 mg/L 1.43170320404722 -DTXSID7057785 Css 3compartmentss Human 95% 2.92 mg/L 3.262 mg/L 0.895156345800123 -DTXSID7057787 Css 3compartmentss Human 95% 0.7986 mg/L 0.4995 mg/L 1.5987987987988 -DTXSID7057789 Css 3compartmentss Human 95% 215.9 mg/L 118.3 mg/L 1.82502113271344 -DTXSID7057810 Css 3compartmentss Human 95% 3.203 mg/L 1.845 mg/L 1.7360433604336 -DTXSID7057812 Css 3compartmentss Human 95% 10.46 mg/L 0.204 mg/L 51.2745098039216 -DTXSID7057814 Css 3compartmentss Human 95% 0.9348 mg/L 4.3e-08 mg/L 21739534.8837209 -DTXSID7057816 Css 3compartmentss Human 95% 3.899 mg/L 1.813 mg/L 2.15057915057915 -DTXSID7057818 Css 3compartmentss Human 95% 7.276 mg/L 0.4063 mg/L 17.907949790795 -DTXSID8020044 Css 3compartmentss Human 95% 6.516 mg/L 4.45 mg/L 1.46426966292135 -DTXSID8020090 Css 3compartmentss Human 95% 1.364 mg/L 0.9147 mg/L 1.49119930031704 -DTXSID8020092 Css 3compartmentss Human 95% 0.1685 mg/L 0.1227 mg/L 1.37326813365933 -DTXSID8020094 Css 3compartmentss Human 95% 7.781 mg/L 4.528 mg/L 1.71841872791519 -DTXSID8020121 Css 3compartmentss Human 95% 10030 mg/L 9305 mg/L 1.07791509940892 -DTXSID8020127 Css 3compartmentss Human 95% 0.8474 mg/L 0.6153 mg/L 1.37721436697546 -DTXSID8020129 Css 3compartmentss Human 95% 6.638 mg/L 4.095 mg/L 1.62100122100122 -DTXSID8020175 Css 3compartmentss Human 95% 547.4 mg/L 636.6 mg/L 0.859880615771285 -DTXSID8020179 Css 3compartmentss Human 95% 0.635 mg/L 0.4583 mg/L 1.38555531311368 -DTXSID8020200 Css 3compartmentss Human 95% 6.153 mg/L 4.057 mg/L 1.51663790978556 -DTXSID8020202 Css 3compartmentss Human 95% 1.1 mg/L 0.6569 mg/L 1.67453189222104 -DTXSID8020252 Css 3compartmentss Human 95% 4.662 mg/L 3.049 mg/L 1.52902591013447 -DTXSID8020331 Css 3compartmentss Human 95% 121.6 mg/L 63.9 mg/L 1.90297339593114 -DTXSID8020337 Css 3compartmentss Human 95% 0.392 mg/L 0.0005001 mg/L 783.843231353729 -DTXSID8020381 Css 3compartmentss Human 95% 4.202 mg/L 0.0003809 mg/L 11031.7668679443 -DTXSID8020383 Css 3compartmentss Human 95% 12.95 mg/L 6.712 mg/L 1.92938021454112 -DTXSID8020410 Css 3compartmentss Human 95% 4.782 mg/L 1.017 mg/L 4.70206489675516 -DTXSID8020462 Css 3compartmentss Human 95% 5.575 mg/L 2.053 mg/L 2.71553823672674 -DTXSID8020464 Css 3compartmentss Human 95% 0.1002 mg/L 0.06408 mg/L 1.56367041198502 -DTXSID8020466 Css 3compartmentss Human 95% 0.7879 mg/L 0.8691 mg/L 0.906570014958003 -DTXSID8020468 Css 3compartmentss Human 95% 0.7668 mg/L 0.3739 mg/L 2.05081572612998 -DTXSID8020541 Css 3compartmentss Human 95% 9.833 mg/L 9.001 mg/L 1.09243417398067 -DTXSID8020543 Css 3compartmentss Human 95% 7.165 mg/L 4.407 mg/L 1.62582255502609 -DTXSID8020545 Css 3compartmentss Human 95% 0.9477 mg/L 0.5601 mg/L 1.69201928227102 -DTXSID8020591 Css 3compartmentss Human 95% 0.7596 mg/L 0.4913 mg/L 1.54610217789538 -DTXSID8020593 Css 3compartmentss Human 95% 4.724 mg/L 3.572 mg/L 1.32250839865621 -DTXSID8020597 Css 3compartmentss Human 95% 7.174 mg/L 4.528 mg/L 1.58436395759717 -DTXSID8020620 Css 3compartmentss Human 95% 2.862 mg/L 0.7206 mg/L 3.97169025811823 -DTXSID8020622 Css 3compartmentss Human 95% NA mg/L NA NA NA -DTXSID8020624 Css 3compartmentss Human 95% 7.282 mg/L 4.559 mg/L 1.59728010528625 -DTXSID8020626 Css 3compartmentss Human 95% 0.1066 mg/L 0.05588 mg/L 1.90765926986399 -DTXSID8020628 Css 3compartmentss Human 95% 1.389 mg/L 0.9697 mg/L 1.43240177374446 -DTXSID8020674 Css 3compartmentss Human 95% 2.6 mg/L 1.461 mg/L 1.77960301163587 -DTXSID8020678 Css 3compartmentss Human 95% 32.05 mg/L 20.29 mg/L 1.57959586002957 -DTXSID8020703 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID8020707 Css 3compartmentss Human 95% 0.5838 mg/L 0.339 mg/L 1.72212389380531 -DTXSID8020709 Css 3compartmentss Human 95% 11.62 mg/L 6.958 mg/L 1.67002012072435 -DTXSID8020753 Css 3compartmentss Human 95% 5.172 mg/L 3.319 mg/L 1.55830069297981 -DTXSID8020755 Css 3compartmentss Human 95% 2.087 mg/L 1.273 mg/L 1.6394344069128 -DTXSID8020757 Css 3compartmentss Human 95% 8.267 mg/L 5.125 mg/L 1.61307317073171 -DTXSID8020830 Css 3compartmentss Human 95% 51.12 mg/L 32.82 mg/L 1.55758683729433 -DTXSID8020834 Css 3compartmentss Human 95% 6.023 mg/L 3.88 mg/L 1.55231958762887 -DTXSID8020838 Css 3compartmentss Human 95% 5.228 mg/L 2.286 mg/L 2.28696412948381 -DTXSID8020880 Css 3compartmentss Human 95% 0.28 mg/L 0.1861 mg/L 1.5045674368619 -DTXSID8020886 Css 3compartmentss Human 95% 0.3729 mg/L 0.2507 mg/L 1.48743518149182 -DTXSID8020911 Css 3compartmentss Human 95% 367.5 mg/L 107.9 mg/L 3.40593141797961 -DTXSID8020915 Css 3compartmentss Human 95% 104.7 mg/L 57.78 mg/L 1.81204569055036 -DTXSID8020917 Css 3compartmentss Human 95% 0.2116 mg/L 0.1507 mg/L 1.40411413404114 -DTXSID8020919 Css 3compartmentss Human 95% 1.766 mg/L 0.9926 mg/L 1.77916582712069 -DTXSID8020963 Css 3compartmentss Human 95% 15.17 mg/L 8.649 mg/L 1.75395999537519 -DTXSID8020965 Css 3compartmentss Human 95% 6.408 mg/L 4.218 mg/L 1.51920341394026 -DTXSID8021060 Css 3compartmentss Human 95% 2.867 mg/L 1.053 mg/L 2.72269705603039 -DTXSID8021062 Css 3compartmentss Human 95% 2.967 mg/L 1.928 mg/L 1.53890041493776 -DTXSID8021141 Css 3compartmentss Human 95% 0.9068 mg/L 0.5816 mg/L 1.55914718019257 -DTXSID8021145 Css 3compartmentss Human 95% 0.4854 mg/L 0.32 mg/L 1.516875 -DTXSID8021147 Css 3compartmentss Human 95% 0.4211 mg/L 0.2834 mg/L 1.48588567395907 -DTXSID8021191 Css 3compartmentss Human 95% 0.6736 mg/L 0.4825 mg/L 1.3960621761658 -DTXSID8021193 Css 3compartmentss Human 95% 0.1891 mg/L 0.09372 mg/L 2.01771233461374 -DTXSID8021197 Css 3compartmentss Human 95% 7.376 mg/L 4.482 mg/L 1.64569388665774 -DTXSID8021199 Css 3compartmentss Human 95% 4.022 mg/L 1.253 mg/L 3.20989624900239 -DTXSID8021222 Css 3compartmentss Human 95% 2.31 mg/L 1.471 mg/L 1.57036029911625 -DTXSID8021224 Css 3compartmentss Human 95% 1510 mg/L 835.1 mg/L 1.80816668662436 -DTXSID8021270 Css 3compartmentss Human 95% 46.75 mg/L 2.195 mg/L 21.2984054669704 -DTXSID8021272 Css 3compartmentss Human 95% 0.06288 mg/L 0.03573 mg/L 1.75986565910999 -DTXSID8021276 Css 3compartmentss Human 95% 7.573 mg/L 4.755 mg/L 1.59263932702419 -DTXSID8021278 Css 3compartmentss Human 95% 5.248 mg/L 3.559 mg/L 1.4745715088508 -DTXSID8021301 Css 3compartmentss Human 95% 3270 mg/L 1958 mg/L 1.67007150153218 -DTXSID8021305 Css 3compartmentss Human 95% 3.266 mg/L 1.904 mg/L 1.71533613445378 -DTXSID8021309 Css 3compartmentss Human 95% 103.3 mg/L 50.78 mg/L 2.03426545884206 -DTXSID8021351 Css 3compartmentss Human 95% 12.21 mg/L 7.435 mg/L 1.64223268325488 -DTXSID8021359 Css 3compartmentss Human 95% 50.28 mg/L 29.04 mg/L 1.73140495867769 -DTXSID8021484 Css 3compartmentss Human 95% 11.87 mg/L 7.16 mg/L 1.65782122905028 -DTXSID8021488 Css 3compartmentss Human 95% 11.49 mg/L 7.215 mg/L 1.59251559251559 -DTXSID8021515 Css 3compartmentss Human 95% 8.007 mg/L 5.005 mg/L 1.5998001998002 -DTXSID8021517 Css 3compartmentss Human 95% 8.733 mg/L 5.464 mg/L 1.59827964860908 -DTXSID8021519 Css 3compartmentss Human 95% 7.259 mg/L 4.765 mg/L 1.52339979013641 -DTXSID8021561 Css 3compartmentss Human 95% 3.157 mg/L 3.24 mg/L 0.974382716049383 -DTXSID8021563 Css 3compartmentss Human 95% 164.2 mg/L 98.58 mg/L 1.66565226212213 -DTXSID8021640 Css 3compartmentss Human 95% 2.184 mg/L 1.389 mg/L 1.57235421166307 -DTXSID8021642 Css 3compartmentss Human 95% 454.9 mg/L 9724 mg/L 0.0467811600164541 -DTXSID8021644 Css 3compartmentss Human 95% 2.548 mg/L 1.575 mg/L 1.61777777777778 -DTXSID8021646 Css 3compartmentss Human 95% 6.657 mg/L 4.227 mg/L 1.57487579843861 -DTXSID8021648 Css 3compartmentss Human 95% 9.204 mg/L 5.591 mg/L 1.64621713468074 -DTXSID8021690 Css 3compartmentss Human 95% 30.98 mg/L 17.85 mg/L 1.73557422969188 -DTXSID8021721 Css 3compartmentss Human 95% 0.443 mg/L 0.305 mg/L 1.45245901639344 -DTXSID8021725 Css 3compartmentss Human 95% 1.278 mg/L 0.6381 mg/L 2.00282087447109 -DTXSID8021729 Css 3compartmentss Human 95% 85.74 mg/L 45.86 mg/L 1.86960313999128 -DTXSID8021771 Css 3compartmentss Human 95% 2.715 mg/L 2.331 mg/L 1.16473616473616 -DTXSID8021775 Css 3compartmentss Human 95% 4.805 mg/L 4.242 mg/L 1.13272041489863 -DTXSID8021777 Css 3compartmentss Human 95% 7.624 mg/L 4.752 mg/L 1.6043771043771 -DTXSID8021804 Css 3compartmentss Human 95% 0.0664 mg/L 0.04419 mg/L 1.50260239873275 -DTXSID8021808 Css 3compartmentss Human 95% 0.3022 mg/L 0.2335 mg/L 1.29421841541756 -DTXSID8021856 Css 3compartmentss Human 95% 2.58 mg/L 1.219 mg/L 2.11648892534865 -DTXSID8021931 Css 3compartmentss Human 95% 8.031 mg/L 5.658 mg/L 1.41940615058324 -DTXSID8021937 Css 3compartmentss Human 95% 12.84 mg/L 14.35 mg/L 0.894773519163763 -DTXSID8022080 Css 3compartmentss Human 95% 432.6 mg/L 933.9 mg/L 0.463218760038548 -DTXSID8022082 Css 3compartmentss Human 95% 3.28 mg/L 2.122 mg/L 1.54571159283695 -DTXSID8022084 Css 3compartmentss Human 95% 1.508 mg/L 0.8927 mg/L 1.68925730928643 -DTXSID8022086 Css 3compartmentss Human 95% 8.044 mg/L 5.149 mg/L 1.56224509613517 -DTXSID8022111 Css 3compartmentss Human 95% 4.611 mg/L 2.273 mg/L 2.02859656841179 -DTXSID8022117 Css 3compartmentss Human 95% 0.07108 mg/L 0.0448 mg/L 1.58660714285714 -DTXSID8022161 Css 3compartmentss Human 95% 68.99 mg/L 40.73 mg/L 1.6938374662411 -DTXSID8022246 Css 3compartmentss Human 95% 1.444 mg/L 0.9884 mg/L 1.46094698502631 -DTXSID8022292 Css 3compartmentss Human 95% 19.46 mg/L 0.03256 mg/L 597.665847665848 -DTXSID8022325 Css 3compartmentss Human 95% 2.507 mg/L 0.2163 mg/L 11.5903837263061 -DTXSID8022329 Css 3compartmentss Human 95% 5.303 mg/L 3.324 mg/L 1.5953670276775 -DTXSID8022371 Css 3compartmentss Human 95% 3.426 mg/L 1.976 mg/L 1.73380566801619 -DTXSID8022377 Css 3compartmentss Human 95% 10.15 mg/L 3.059 mg/L 3.31807780320366 -DTXSID8022404 Css 3compartmentss Human 95% 0.868 mg/L 0.4776 mg/L 1.81742043551089 -DTXSID8022406 Css 3compartmentss Human 95% 7.211 mg/L 3.559 mg/L 2.02613093565608 -DTXSID8022408 Css 3compartmentss Human 95% 11.19 mg/L 6.64 mg/L 1.68524096385542 -DTXSID8022585 Css 3compartmentss Human 95% 2.575 mg/L 2.132 mg/L 1.2077861163227 -DTXSID8022589 Css 3compartmentss Human 95% 4.198 mg/L 2.5 mg/L 1.6792 -DTXSID8022610 Css 3compartmentss Human 95% 0.7119 mg/L 0.3033 mg/L 2.34718100890208 -DTXSID8022612 Css 3compartmentss Human 95% 0.9255 mg/L 0.5069 mg/L 1.82580390609588 -DTXSID8022614 Css 3compartmentss Human 95% 26.18 mg/L 13.47 mg/L 1.94357832219748 -DTXSID8022741 Css 3compartmentss Human 95% 1.079 mg/L 0.6213 mg/L 1.73668115242234 -DTXSID8022743 Css 3compartmentss Human 95% 0.7585 mg/L 0.4479 mg/L 1.69345836124135 -DTXSID8022747 Css 3compartmentss Human 95% 1.871 mg/L 0.3854 mg/L 4.85469641930462 -DTXSID8022749 Css 3compartmentss Human 95% 7.436 mg/L 5.094 mg/L 1.45975657636435 -DTXSID8022822 Css 3compartmentss Human 95% 37.07 mg/L 21.59 mg/L 1.71699861046781 -DTXSID8022824 Css 3compartmentss Human 95% 0.8137 mg/L 0.5459 mg/L 1.49056603773585 -DTXSID8022828 Css 3compartmentss Human 95% 2.692 mg/L 3.614 mg/L 0.744881018262313 -DTXSID8022870 Css 3compartmentss Human 95% 5.154 mg/L 2.071 mg/L 2.48865282472236 -DTXSID8022872 Css 3compartmentss Human 95% 4.183 mg/L 0.2238 mg/L 18.6907953529937 -DTXSID8022901 Css 3compartmentss Human 95% 5.788 mg/L 3.874 mg/L 1.49406298399587 -DTXSID8022955 Css 3compartmentss Human 95% 12.01 mg/L 0.05278 mg/L 227.54831375521 -DTXSID8022959 Css 3compartmentss Human 95% 3.267 mg/L 1.877 mg/L 1.74054342035162 -DTXSID8023000 Css 3compartmentss Human 95% 17.58 mg/L 0.0001037 mg/L 169527.483124397 -DTXSID8023050 Css 3compartmentss Human 95% 493.9 mg/L 260.6 mg/L 1.89524174980813 -DTXSID8023054 Css 3compartmentss Human 95% 0.1026 mg/L 0.04445 mg/L 2.3082114735658 -DTXSID8023137 Css 3compartmentss Human 95% 1.675 mg/L 0.8534 mg/L 1.96273728614952 -DTXSID8023181 Css 3compartmentss Human 95% 0.2824 mg/L 0.1245 mg/L 2.26827309236948 -DTXSID8023183 Css 3compartmentss Human 95% 0.006254 mg/L 0.00499 mg/L 1.25330661322645 -DTXSID8023185 Css 3compartmentss Human 95% 5.505 mg/L 3.307 mg/L 1.66465074085274 -DTXSID8023187 Css 3compartmentss Human 95% 0.8801 mg/L 0.5335 mg/L 1.64967197750703 -DTXSID8023214 Css 3compartmentss Human 95% 13790 mg/L 7910 mg/L 1.74336283185841 -DTXSID8023216 Css 3compartmentss Human 95% 997.8 mg/L 584.6 mg/L 1.70680807389668 -DTXSID8023260 Css 3compartmentss Human 95% 2.053 mg/L 1.227 mg/L 1.67318663406683 -DTXSID8023262 Css 3compartmentss Human 95% 39.17 mg/L 0.1938 mg/L 202.115583075335 -DTXSID8023345 Css 3compartmentss Human 95% 1.019 mg/L 0.7368 mg/L 1.38300760043431 -DTXSID8023347 Css 3compartmentss Human 95% 1.14 mg/L 0.6436 mg/L 1.77128651336234 -DTXSID8023349 Css 3compartmentss Human 95% 0.02605 mg/L 0.01521 mg/L 1.71268902038133 -DTXSID8023393 Css 3compartmentss Human 95% 17.34 mg/L 18.42 mg/L 0.941368078175896 -DTXSID8023395 Css 3compartmentss Human 95% 0.9667 mg/L 0.0007051 mg/L 1371.01120408453 -DTXSID8023422 Css 3compartmentss Human 95% 13.16 mg/L 9.043 mg/L 1.45526926904788 -DTXSID8023426 Css 3compartmentss Human 95% 0.7903 mg/L 0.5473 mg/L 1.44399780741823 -DTXSID8023470 Css 3compartmentss Human 95% 27.18 mg/L 14.45 mg/L 1.88096885813149 -DTXSID8023472 Css 3compartmentss Human 95% 0.01775 mg/L 0 mg/L Inf -DTXSID8023474 Css 3compartmentss Human 95% 0.6337 mg/L 0.0001297 mg/L 4885.89051657672 -DTXSID8023476 Css 3compartmentss Human 95% 1.727 mg/L 1.091 mg/L 1.58295142071494 -DTXSID8023478 Css 3compartmentss Human 95% 48.66 mg/L 113 mg/L 0.430619469026549 -DTXSID8023505 Css 3compartmentss Human 95% 1.782 mg/L 0.9294 mg/L 1.91736604260813 -DTXSID8023551 Css 3compartmentss Human 95% 23.63 mg/L 16.23 mg/L 1.45594577942083 -DTXSID8023557 Css 3compartmentss Human 95% 5.533 mg/L 3.307 mg/L 1.67311762927124 -DTXSID8023630 Css 3compartmentss Human 95% 7.935 mg/L 5.36 mg/L 1.48041044776119 -DTXSID8023632 Css 3compartmentss Human 95% 7.149 mg/L 4.462 mg/L 1.60219632451815 -DTXSID8023636 Css 3compartmentss Human 95% 60.66 mg/L 0.0001915 mg/L 316762.402088773 -DTXSID8023638 Css 3compartmentss Human 95% 47.02 mg/L 23.19 mg/L 2.02759810263044 -DTXSID8023680 Css 3compartmentss Human 95% 5.515 mg/L 3.307 mg/L 1.66767462957363 -DTXSID8023688 Css 3compartmentss Human 95% 6.801 mg/L 4.442 mg/L 1.53106708689779 -DTXSID8023713 Css 3compartmentss Human 95% 0.004187 mg/L 0.002461 mg/L 1.70134091832588 -DTXSID8023715 Css 3compartmentss Human 95% 2.828 mg/L 0.3629 mg/L 7.79278038027005 -DTXSID8023719 Css 3compartmentss Human 95% 111.9 mg/L 7.712 mg/L 14.5098547717842 -DTXSID8023846 Css 3compartmentss Human 95% 5.705 mg/L 3.548 mg/L 1.60794813979707 -DTXSID8023848 Css 3compartmentss Human 95% 0.4573 mg/L 0.3054 mg/L 1.49738048461035 -DTXSID8023890 Css 3compartmentss Human 95% 1.337 mg/L 0.8565 mg/L 1.56100408639813 -DTXSID8023892 Css 3compartmentss Human 95% 35.63 mg/L 6.391 mg/L 5.5750273822563 -DTXSID8024072 Css 3compartmentss Human 95% 16.06 mg/L 11.05 mg/L 1.45339366515837 -DTXSID8024101 Css 3compartmentss Human 95% 9.716 mg/L 5.269 mg/L 1.84399316758398 -DTXSID8024107 Css 3compartmentss Human 95% 6.375 mg/L 4.328 mg/L 1.47296672828096 -DTXSID8024109 Css 3compartmentss Human 95% 19.92 mg/L 6.152 mg/L 3.23797139141743 -DTXSID8024151 Css 3compartmentss Human 95% 226.4 mg/L 170.2 mg/L 1.33019976498237 -DTXSID8024153 Css 3compartmentss Human 95% 6.574 mg/L 2.668e-05 mg/L 246401.79910045 -DTXSID8024157 Css 3compartmentss Human 95% 384.3 mg/L 62.52 mg/L 6.1468330134357 -DTXSID8024159 Css 3compartmentss Human 95% 5.946 mg/L 1.993 mg/L 2.98344204716508 -DTXSID8024234 Css 3compartmentss Human 95% 1.762 mg/L 1.345 mg/L 1.31003717472119 -DTXSID8024236 Css 3compartmentss Human 95% 350.8 mg/L 9739 mg/L 0.0360201252695349 -DTXSID8024238 Css 3compartmentss Human 95% 68.35 mg/L 31.06 mg/L 2.2005795235029 -DTXSID8024280 Css 3compartmentss Human 95% 6.072 mg/L 2.322 mg/L 2.61498708010336 -DTXSID8024284 Css 3compartmentss Human 95% 5.188 mg/L 2.32 mg/L 2.23620689655172 -DTXSID8024286 Css 3compartmentss Human 95% 7.103 mg/L 4.536 mg/L 1.56591710758377 -DTXSID8024311 Css 3compartmentss Human 95% 8.864 mg/L 5.528 mg/L 1.60347322720695 -DTXSID8024315 Css 3compartmentss Human 95% 3.757 mg/L 2.082 mg/L 1.8045148895293 -DTXSID8024317 Css 3compartmentss Human 95% 12.37 mg/L 6.828 mg/L 1.81165787932044 -DTXSID8024498 Css 3compartmentss Human 95% 1.677 mg/L 1.656 mg/L 1.01268115942029 -DTXSID8024523 Css 3compartmentss Human 95% 0.9855 mg/L 0.8244 mg/L 1.19541484716157 -DTXSID8024529 Css 3compartmentss Human 95% 0.2811 mg/L 0.1954 mg/L 1.43858751279427 -DTXSID8024573 Css 3compartmentss Human 95% 2.846 mg/L 1.75 mg/L 1.62628571428571 -DTXSID8024602 Css 3compartmentss Human 95% 0.002674 mg/L 0.002697 mg/L 0.991472005932518 -DTXSID8024608 Css 3compartmentss Human 95% 1.314 mg/L 0.01212 mg/L 108.415841584158 -DTXSID8024652 Css 3compartmentss Human 95% 3.494 mg/L 2.307 mg/L 1.51452102297356 -DTXSID8024733 Css 3compartmentss Human 95% 0.5605 mg/L 0.4095 mg/L 1.36874236874237 -DTXSID8024787 Css 3compartmentss Human 95% 13.82 mg/L 9.269 mg/L 1.49099147696623 -DTXSID8024862 Css 3compartmentss Human 95% 0.3554 mg/L 0.2437 mg/L 1.45835043085761 -DTXSID8024864 Css 3compartmentss Human 95% 5.701 mg/L 3.743 mg/L 1.52310980496928 -DTXSID8024866 Css 3compartmentss Human 95% 28.2 mg/L 8.5 mg/L 3.31764705882353 -DTXSID8024947 Css 3compartmentss Human 95% 23.74 mg/L 0.5229 mg/L 45.4006502199273 -DTXSID8024993 Css 3compartmentss Human 95% 7.836 mg/L 4.886 mg/L 1.60376586164552 -DTXSID8024997 Css 3compartmentss Human 95% 7.398 mg/L 4.794 mg/L 1.54317897371715 -DTXSID8024999 Css 3compartmentss Human 95% 2.426 mg/L 1.014 mg/L 2.39250493096647 -DTXSID8025040 Css 3compartmentss Human 95% 9.447 mg/L 2.749 mg/L 3.43652237177155 -DTXSID8025046 Css 3compartmentss Human 95% 0.02339 mg/L 0.01412 mg/L 1.65651558073654 -DTXSID8025094 Css 3compartmentss Human 95% 0.04175 mg/L 0.02425 mg/L 1.72164948453608 -DTXSID8025096 Css 3compartmentss Human 95% 5.896 mg/L 4.274 mg/L 1.37950397753861 -DTXSID8025258 Css 3compartmentss Human 95% 0.1708 mg/L 0.115 mg/L 1.48521739130435 -DTXSID8025331 Css 3compartmentss Human 95% 7.675 mg/L 5.205 mg/L 1.4745437079731 -DTXSID8025337 Css 3compartmentss Human 95% 8.803 mg/L 5.475 mg/L 1.60785388127854 -DTXSID8025466 Css 3compartmentss Human 95% 97.61 mg/L 0.5408 mg/L 180.491863905325 -DTXSID8025591 Css 3compartmentss Human 95% 3.169 mg/L 2.115 mg/L 1.4983451536643 -DTXSID8025593 Css 3compartmentss Human 95% 2.762 mg/L 1.379 mg/L 2.00290065264685 -DTXSID8025595 Css 3compartmentss Human 95% 5.621 mg/L 3.275 mg/L 1.7163358778626 -DTXSID8025599 Css 3compartmentss Human 95% 1.939 mg/L 1.578 mg/L 1.22877059569075 -DTXSID8025628 Css 3compartmentss Human 95% 0.846 mg/L 0.5617 mg/L 1.50614206871996 -DTXSID8025670 Css 3compartmentss Human 95% 8.413 mg/L 4.951 mg/L 1.69925267622703 -DTXSID8025707 Css 3compartmentss Human 95% 0.2694 mg/L 0.1664 mg/L 1.61899038461538 -DTXSID8025709 Css 3compartmentss Human 95% 7876 mg/L 5.879 mg/L 1339.68361966321 -DTXSID8025751 Css 3compartmentss Human 95% 6.306 mg/L 4.147 mg/L 1.52061731372076 -DTXSID8025759 Css 3compartmentss Human 95% 5.886 mg/L 3.426 mg/L 1.71803852889667 -DTXSID8025886 Css 3compartmentss Human 95% 0.3746 mg/L 0.22 mg/L 1.70272727272727 -DTXSID8025888 Css 3compartmentss Human 95% 1.032 mg/L 0.7238 mg/L 1.42580823431887 -DTXSID8025961 Css 3compartmentss Human 95% 8.338 mg/L 5.121 mg/L 1.6281976176528 -DTXSID8025963 Css 3compartmentss Human 95% 0.2869 mg/L 0.1907 mg/L 1.50445726271631 -DTXSID8025967 Css 3compartmentss Human 95% 7.472 mg/L 5.191 mg/L 1.43941437102678 -DTXSID8026018 Css 3compartmentss Human 95% 85.11 mg/L 58.69 mg/L 1.45016186743909 -DTXSID8026060 Css 3compartmentss Human 95% 2.171 mg/L 1.182 mg/L 1.83671742808799 -DTXSID8026064 Css 3compartmentss Human 95% 1.688 mg/L 1.162 mg/L 1.4526678141136 -DTXSID8026068 Css 3compartmentss Human 95% 17.71 mg/L 10.74 mg/L 1.64897579143389 -DTXSID8026141 Css 3compartmentss Human 95% 8.057 mg/L 4.995 mg/L 1.61301301301301 -DTXSID8026147 Css 3compartmentss Human 95% 0.7871 mg/L 0.5085 mg/L 1.54788593903638 -DTXSID8026220 Css 3compartmentss Human 95% 0.2142 mg/L 0.1311 mg/L 1.63386727688787 -DTXSID8026224 Css 3compartmentss Human 95% 2.721 mg/L 1.976 mg/L 1.37702429149798 -DTXSID8026228 Css 3compartmentss Human 95% 7.545 mg/L 5.232 mg/L 1.4420871559633 -DTXSID8026270 Css 3compartmentss Human 95% 0.6152 mg/L 0.351 mg/L 1.75270655270655 -DTXSID8026303 Css 3compartmentss Human 95% 285.4 mg/L 177.9 mg/L 1.60427206295672 -DTXSID8026305 Css 3compartmentss Human 95% 1.051 mg/L 0.6945 mg/L 1.51331893448524 -DTXSID8026307 Css 3compartmentss Human 95% 0.8234 mg/L 0.5583 mg/L 1.47483431846677 -DTXSID8026309 Css 3compartmentss Human 95% 2.04 mg/L 1.454 mg/L 1.40302613480055 -DTXSID8026432 Css 3compartmentss Human 95% 7.548 mg/L 4.773 mg/L 1.58139534883721 -DTXSID8026436 Css 3compartmentss Human 95% 0.3799 mg/L 0.1925 mg/L 1.97350649350649 -DTXSID8026513 Css 3compartmentss Human 95% 3.24 mg/L 1.409 mg/L 2.29950319375444 -DTXSID8026515 Css 3compartmentss Human 95% 4.882 mg/L 2.329 mg/L 2.09617861743237 -DTXSID8026519 Css 3compartmentss Human 95% 8.006 mg/L 0.0243 mg/L 329.465020576132 -DTXSID8026563 Css 3compartmentss Human 95% 499.7 mg/L 925.7 mg/L 0.539807713081992 -DTXSID8026698 Css 3compartmentss Human 95% 0.4154 mg/L 0.2763 mg/L 1.50343829171191 -DTXSID8026725 Css 3compartmentss Human 95% 516.7 mg/L 2841 mg/L 0.181872580077438 -DTXSID8026727 Css 3compartmentss Human 95% 1.659 mg/L 1.303 mg/L 1.27321565617805 -DTXSID8026773 Css 3compartmentss Human 95% 2.99 mg/L 3.398 mg/L 0.879929370217775 -DTXSID8026775 Css 3compartmentss Human 95% 7.948 mg/L 4.956 mg/L 1.60371267150928 -DTXSID8026931 Css 3compartmentss Human 95% 315.5 mg/L 9739 mg/L 0.032395523154328 -DTXSID8026933 Css 3compartmentss Human 95% 0.02554 mg/L 2e-09 mg/L 12770000 -DTXSID8026935 Css 3compartmentss Human 95% 1011 mg/L 9739 mg/L 0.103809426019098 -DTXSID8026981 Css 3compartmentss Human 95% 2.807 mg/L 1.668 mg/L 1.68285371702638 -DTXSID8027032 Css 3compartmentss Human 95% 4.453 mg/L 3.066 mg/L 1.45238095238095 -DTXSID8027034 Css 3compartmentss Human 95% 5.535 mg/L 3.307 mg/L 1.67372240701542 -DTXSID8027036 Css 3compartmentss Human 95% 5.028 mg/L 3.372 mg/L 1.49110320284698 -DTXSID8027084 Css 3compartmentss Human 95% 4.34 mg/L 2.698 mg/L 1.60859896219422 -DTXSID8027086 Css 3compartmentss Human 95% 8510 mg/L 9739 mg/L 0.8738063456207 -DTXSID8027113 Css 3compartmentss Human 95% 8.202 mg/L 5.75 mg/L 1.4264347826087 -DTXSID8027163 Css 3compartmentss Human 95% 6.893 mg/L 4.458 mg/L 1.5462090623598 -DTXSID8027169 Css 3compartmentss Human 95% 7.122 mg/L 4.477 mg/L 1.59079740897923 -DTXSID8027240 Css 3compartmentss Human 95% 2.636 mg/L 1.922 mg/L 1.37148803329865 -DTXSID8027246 Css 3compartmentss Human 95% 5.092 mg/L 3.161 mg/L 1.61088263207846 -DTXSID8027292 Css 3compartmentss Human 95% 1.106 mg/L 7.261e-06 mg/L 152320.616994904 -DTXSID8027294 Css 3compartmentss Human 95% 2.145 mg/L 2.121 mg/L 1.01131541725601 -DTXSID8027321 Css 3compartmentss Human 95% 7.963 mg/L 4.901 mg/L 1.62477045500918 -DTXSID8027323 Css 3compartmentss Human 95% 10.9 mg/L 6.191 mg/L 1.76062025520917 -DTXSID8027377 Css 3compartmentss Human 95% 1.675 mg/L 1.059 mg/L 1.58168083097262 -DTXSID8027402 Css 3compartmentss Human 95% 0.02561 mg/L 0.01612 mg/L 1.58870967741935 -DTXSID8027452 Css 3compartmentss Human 95% 1.882 mg/L 1.093 mg/L 1.72186642268984 -DTXSID8027454 Css 3compartmentss Human 95% 5.595 mg/L 3.334 mg/L 1.67816436712657 -DTXSID8027585 Css 3compartmentss Human 95% 0.4688 mg/L 0.2831 mg/L 1.65595196043801 -DTXSID8027589 Css 3compartmentss Human 95% 7.083 mg/L 4.863 mg/L 1.45650832819247 -DTXSID8027747 Css 3compartmentss Human 95% 8.994 mg/L 6.239 mg/L 1.44157717582946 -DTXSID8027793 Css 3compartmentss Human 95% 8.421 mg/L 5.334 mg/L 1.57874015748032 -DTXSID8027795 Css 3compartmentss Human 95% 76.89 mg/L 94.56 mg/L 0.813134517766497 -DTXSID8027797 Css 3compartmentss Human 95% 4.214 mg/L 1.418 mg/L 2.97179125528914 -DTXSID8027822 Css 3compartmentss Human 95% 0.9729 mg/L 0.9431 mg/L 1.03159792174743 -DTXSID8027826 Css 3compartmentss Human 95% 3.797 mg/L 2.279 mg/L 1.66608161474331 -DTXSID8027870 Css 3compartmentss Human 95% 1447 mg/L 3267 mg/L 0.442913988368534 -DTXSID8027878 Css 3compartmentss Human 95% 3.282 mg/L 2.403 mg/L 1.36579275905119 -DTXSID8027905 Css 3compartmentss Human 95% 5.275 mg/L 1.522 mg/L 3.46583442838371 -DTXSID8027955 Css 3compartmentss Human 95% 73.26 mg/L 50.95 mg/L 1.4378802747792 -DTXSID8027959 Css 3compartmentss Human 95% 0.7962 mg/L 0.5011 mg/L 1.58890441029735 -DTXSID8028842 Css 3compartmentss Human 95% 6.899 mg/L 4.327 mg/L 1.59440721053848 -DTXSID8029072 Css 3compartmentss Human 95% 11.3 mg/L 6.874 mg/L 1.64387547279604 -DTXSID8029105 Css 3compartmentss Human 95% 3.371 mg/L 2.053 mg/L 1.64198733560643 -DTXSID8029153 Css 3compartmentss Human 95% 6.813 mg/L 2.362 mg/L 2.8844199830652 -DTXSID8029157 Css 3compartmentss Human 95% 10.41 mg/L 4.244 mg/L 2.45287464655985 -DTXSID8029159 Css 3compartmentss Human 95% 5.049 mg/L 0.4578 mg/L 11.0288335517693 -DTXSID8029230 Css 3compartmentss Human 95% 5.013 mg/L 3.711 mg/L 1.35084882780922 -DTXSID8029232 Css 3compartmentss Human 95% 3.127 mg/L 1.646 mg/L 1.89975698663426 -DTXSID8029236 Css 3compartmentss Human 95% 44.3 mg/L 0.0001847 mg/L 239848.402815376 -DTXSID8029280 Css 3compartmentss Human 95% 0.4443 mg/L 0.2814 mg/L 1.57889125799574 -DTXSID8029282 Css 3compartmentss Human 95% 2.089 mg/L 0.5066 mg/L 4.12356889064351 -DTXSID8029315 Css 3compartmentss Human 95% 5.529 mg/L 1.045e-05 mg/L 529090.909090909 -DTXSID8029317 Css 3compartmentss Human 95% 2.299 mg/L 2.015 mg/L 1.1409429280397 -DTXSID8029369 Css 3compartmentss Human 95% 4.314 mg/L 0.9203 mg/L 4.68760186895578 -DTXSID8029575 Css 3compartmentss Human 95% 23.06 mg/L 40.35 mg/L 0.571499380421313 -DTXSID8029600 Css 3compartmentss Human 95% 5.561 mg/L 3.776 mg/L 1.47272245762712 -DTXSID8029602 Css 3compartmentss Human 95% 0.138 mg/L 0 mg/L Inf -DTXSID8029604 Css 3compartmentss Human 95% 2.907 mg/L 1.896 mg/L 1.53322784810127 -DTXSID8029606 Css 3compartmentss Human 95% 3.117 mg/L 3.583 mg/L 0.869941389896735 -DTXSID8029650 Css 3compartmentss Human 95% 6.845 mg/L 6.914 mg/L 0.99002024877061 -DTXSID8029733 Css 3compartmentss Human 95% 6.845 mg/L 6.914 mg/L 0.99002024877061 -DTXSID8029739 Css 3compartmentss Human 95% 11530 mg/L 9647 mg/L 1.19519021457448 -DTXSID8029868 Css 3compartmentss Human 95% 6592 mg/L 9739 mg/L 0.676866208029572 -DTXSID8030138 Css 3compartmentss Human 95% 3.523 mg/L 2.255 mg/L 1.56230598669623 -DTXSID8030423 Css 3compartmentss Human 95% 11.27 mg/L 0.7094 mg/L 15.8866647871441 -DTXSID8030760 Css 3compartmentss Human 95% 0.9326 mg/L 0.4259 mg/L 2.18971589575018 -DTXSID8031077 Css 3compartmentss Human 95% 62.06 mg/L 29.79 mg/L 2.08324941255455 -DTXSID8031366 Css 3compartmentss Human 95% 3.275 mg/L 1.942 mg/L 1.68640576725026 -DTXSID8031603 Css 3compartmentss Human 95% 3.779 mg/L 2.546 mg/L 1.48428908091123 -DTXSID8031863 Css 3compartmentss Human 95% 6409 mg/L 3705 mg/L 1.72982456140351 -DTXSID8031865 Css 3compartmentss Human 95% 1359 mg/L 813.8 mg/L 1.6699434750553 -DTXSID8032386 Css 3compartmentss Human 95% 2094 mg/L 4386 mg/L 0.477428180574555 -DTXSID8032417 Css 3compartmentss Human 95% 1.715 mg/L 0.4424 mg/L 3.87658227848101 -DTXSID8032544 Css 3compartmentss Human 95% 0.005088 mg/L 0.004771 mg/L 1.06644309369105 -DTXSID8032548 Css 3compartmentss Human 95% 7.215 mg/L 3.213 mg/L 2.24556489262372 -DTXSID8032623 Css 3compartmentss Human 95% 87.56 mg/L 47.84 mg/L 1.83026755852843 -DTXSID8032627 Css 3compartmentss Human 95% 4.752 mg/L 0.02236 mg/L 212.522361359571 -DTXSID8032671 Css 3compartmentss Human 95% 0.23 mg/L 0.1483 mg/L 1.55091031692515 -DTXSID8032673 Css 3compartmentss Human 95% 102 mg/L 64.41 mg/L 1.5836050302748 -DTXSID8032675 Css 3compartmentss Human 95% 5.567 mg/L 0.02884 mg/L 193.030513176144 -DTXSID8033433 Css 3compartmentss Human 95% 10.6 mg/L 6.396 mg/L 1.65728580362727 -DTXSID8033512 Css 3compartmentss Human 95% 3.405 mg/L 1.939 mg/L 1.75605982465188 -DTXSID8033562 Css 3compartmentss Human 95% 20.17 mg/L 13.26 mg/L 1.5211161387632 -DTXSID8033564 Css 3compartmentss Human 95% 12.48 mg/L 7.163 mg/L 1.74228675136116 -DTXSID8033566 Css 3compartmentss Human 95% 6.927 mg/L 4.363 mg/L 1.58766903506761 -DTXSID8033649 Css 3compartmentss Human 95% 7.851 mg/L 4.8 mg/L 1.635625 -DTXSID8033803 Css 3compartmentss Human 95% 0.3122 mg/L 0.2572 mg/L 1.21384136858476 -DTXSID8034085 Css 3compartmentss Human 95% 2.078 mg/L 0.1827 mg/L 11.3738368910783 -DTXSID8034087 Css 3compartmentss Human 95% 0.2873 mg/L 0.1075 mg/L 2.67255813953488 -DTXSID8034241 Css 3compartmentss Human 95% 31.11 mg/L 17.1 mg/L 1.81929824561403 -DTXSID8034324 Css 3compartmentss Human 95% 1.161 mg/L 0.4616 mg/L 2.51516464471404 -DTXSID8034372 Css 3compartmentss Human 95% 85.72 mg/L 46.53 mg/L 1.84225231033742 -DTXSID8034376 Css 3compartmentss Human 95% 9.089 mg/L 1.774 mg/L 5.12344983089064 -DTXSID8034401 Css 3compartmentss Human 95% 272.1 mg/L 19.51 mg/L 13.9466940030753 -DTXSID8034538 Css 3compartmentss Human 95% 207.7 mg/L 113.5 mg/L 1.82995594713656 -DTXSID8034580 Css 3compartmentss Human 95% 2.032 mg/L 1.369 mg/L 1.48429510591673 -DTXSID8034586 Css 3compartmentss Human 95% 14.6 mg/L 4.721 mg/L 3.0925651345054 -DTXSID8034588 Css 3compartmentss Human 95% 18.86 mg/L 2.815 mg/L 6.69982238010657 -DTXSID8034665 Css 3compartmentss Human 95% 3.073 mg/L 3.408 mg/L 0.901701877934272 -DTXSID8034669 Css 3compartmentss Human 95% 0.372 mg/L 0.3309 mg/L 1.12420670897552 -DTXSID8034742 Css 3compartmentss Human 95% 1.067 mg/L 0.05113 mg/L 20.8683747310776 -DTXSID8034792 Css 3compartmentss Human 95% 0.6515 mg/L 0.3923 mg/L 1.66071883762427 -DTXSID8034823 Css 3compartmentss Human 95% 6.381 mg/L 2.484 mg/L 2.56884057971015 -DTXSID8034871 Css 3compartmentss Human 95% 0.8188 mg/L 0.3616 mg/L 2.26438053097345 -DTXSID8034873 Css 3compartmentss Human 95% 5.8 mg/L 1.409 mg/L 4.11639460610362 -DTXSID8034877 Css 3compartmentss Human 95% 8.603 mg/L 3.545 mg/L 2.42679830747532 -DTXSID8034956 Css 3compartmentss Human 95% 310 mg/L 296.1 mg/L 1.04694360013509 -DTXSID8035001 Css 3compartmentss Human 95% 36 mg/L 20.48 mg/L 1.7578125 -DTXSID8035138 Css 3compartmentss Human 95% 11.47 mg/L 6.82 mg/L 1.68181818181818 -DTXSID8035180 Css 3compartmentss Human 95% 887.2 mg/L 2021 mg/L 0.438990598713508 -DTXSID8035186 Css 3compartmentss Human 95% 5.061 mg/L 3.813 mg/L 1.3273013375295 -DTXSID8035217 Css 3compartmentss Human 95% 0.6414 mg/L 0.4195 mg/L 1.52896305125149 -DTXSID8037207 Css 3compartmentss Human 95% 7.163 mg/L 4.662 mg/L 1.53646503646504 -DTXSID8037594 Css 3compartmentss Human 95% 11.07 mg/L 5.394 mg/L 2.05228031145717 -DTXSID8037596 Css 3compartmentss Human 95% 2.297 mg/L 2.122 mg/L 1.08246936852026 -DTXSID8037706 Css 3compartmentss Human 95% 1430 mg/L 798.9 mg/L 1.78996119664539 -DTXSID8037708 Css 3compartmentss Human 95% 1432 mg/L 819.4 mg/L 1.74762020990969 -DTXSID8037750 Css 3compartmentss Human 95% 3.263 mg/L 1.477 mg/L 2.20920785375762 -DTXSID8037752 Css 3compartmentss Human 95% 10.01 mg/L 3.035 mg/L 3.29818780889621 -DTXSID8037754 Css 3compartmentss Human 95% 1.715 mg/L 1.532 mg/L 1.11945169712794 -DTXSID8037756 Css 3compartmentss Human 95% 1.273 mg/L 0.9433 mg/L 1.34951765080038 -DTXSID8038770 Css 3compartmentss Human 95% 9.805 mg/L 6.142 mg/L 1.59638554216867 -DTXSID8038801 Css 3compartmentss Human 95% 6.501 mg/L 3.73 mg/L 1.74289544235925 -DTXSID8038857 Css 3compartmentss Human 95% 4.947 mg/L 3.309 mg/L 1.49501359927471 -DTXSID8039241 Css 3compartmentss Human 95% 0.8849 mg/L 0.7 mg/L 1.26414285714286 -DTXSID8040147 Css 3compartmentss Human 95% 0.7015 mg/L 0.6785 mg/L 1.03389830508475 -DTXSID8040222 Css 3compartmentss Human 95% 1414 mg/L 815 mg/L 1.73496932515337 -DTXSID8040270 Css 3compartmentss Human 95% 9.489 mg/L 5.746 mg/L 1.65140967629655 -DTXSID8040274 Css 3compartmentss Human 95% 9.01 mg/L 0.163 mg/L 55.2760736196319 -DTXSID8040278 Css 3compartmentss Human 95% 7.377 mg/L 0.03385 mg/L 217.932053175775 -DTXSID8040436 Css 3compartmentss Human 95% 9.815 mg/L 5.889 mg/L 1.66666666666667 -DTXSID8040438 Css 3compartmentss Human 95% 2.315 mg/L 1.404 mg/L 1.6488603988604 -DTXSID8040484 Css 3compartmentss Human 95% 0.4783 mg/L 0.316 mg/L 1.51360759493671 -DTXSID8040698 Css 3compartmentss Human 95% 1.783 mg/L 0.9551 mg/L 1.86682022824835 -DTXSID8040723 Css 3compartmentss Human 95% 15.52 mg/L 8.545 mg/L 1.81626682270334 -DTXSID8040725 Css 3compartmentss Human 95% 322.5 mg/L 187.5 mg/L 1.72 -DTXSID8040727 Css 3compartmentss Human 95% 4.815 mg/L 2.582 mg/L 1.86483346243222 -DTXSID8040775 Css 3compartmentss Human 95% 4.395 mg/L 4.603 mg/L 0.954812079078862 -DTXSID8040779 Css 3compartmentss Human 95% 12.76 mg/L 0.0002681 mg/L 47594.1812756434 -DTXSID8040800 Css 3compartmentss Human 95% 7.415 mg/L 4.51 mg/L 1.64412416851441 -DTXSID8041032 Css 3compartmentss Human 95% 0.04572 mg/L 0.03729 mg/L 1.2260659694288 -DTXSID8041034 Css 3compartmentss Human 95% 0.4315 mg/L 0.2185 mg/L 1.97482837528604 -DTXSID8041080 Css 3compartmentss Human 95% 1.088 mg/L 0.6471 mg/L 1.68134755061042 -DTXSID8041115 Css 3compartmentss Human 95% 0.9556 mg/L 0.6112 mg/L 1.56348167539267 -DTXSID8041117 Css 3compartmentss Human 95% 0.04705 mg/L 0.04431 mg/L 1.06183705709772 -DTXSID8041246 Css 3compartmentss Human 95% 5.588 mg/L 3.709 mg/L 1.5066055540577 -DTXSID8041248 Css 3compartmentss Human 95% 8.794 mg/L 1.386 mg/L 6.34487734487735 -DTXSID8041298 Css 3compartmentss Human 95% 5.711 mg/L 3.824 mg/L 1.49346234309623 -DTXSID8041321 Css 3compartmentss Human 95% 5.014 mg/L 3.305 mg/L 1.51709531013616 -DTXSID8041327 Css 3compartmentss Human 95% 7.79 mg/L 4.778 mg/L 1.63038928421934 -DTXSID8041329 Css 3compartmentss Human 95% 37.98 mg/L 0.6926 mg/L 54.8368466647416 -DTXSID8041371 Css 3compartmentss Human 95% 7.073 mg/L 4.696 mg/L 1.50617546848382 -DTXSID8041373 Css 3compartmentss Human 95% 9.528 mg/L 10.18 mg/L 0.935952848722986 -DTXSID8041379 Css 3compartmentss Human 95% 13.61 mg/L 0.1477 mg/L 92.1462423832092 -DTXSID8041400 Css 3compartmentss Human 95% 7.842 mg/L 5.859 mg/L 1.33845366103431 -DTXSID8041404 Css 3compartmentss Human 95% 4.299 mg/L 2.806 mg/L 1.53207412687099 -DTXSID8041452 Css 3compartmentss Human 95% 5.475 mg/L 3.349 mg/L 1.63481636309346 -DTXSID8041610 Css 3compartmentss Human 95% 5.642 mg/L 3.628 mg/L 1.55512679162073 -DTXSID8041743 Css 3compartmentss Human 95% 38.43 mg/L 0.401 mg/L 95.8354114713217 -DTXSID8041745 Css 3compartmentss Human 95% 9.413 mg/L 3.887 mg/L 2.42166195009004 -DTXSID8041793 Css 3compartmentss Human 95% 137.7 mg/L 76.9 mg/L 1.79063719115735 -DTXSID8041797 Css 3compartmentss Human 95% 297.3 mg/L 161.8 mg/L 1.83745364647713 -DTXSID8041799 Css 3compartmentss Human 95% 247.1 mg/L 132.2 mg/L 1.86913767019667 -DTXSID8041828 Css 3compartmentss Human 95% 1.049 mg/L 0.5564 mg/L 1.88533429187635 -DTXSID8041901 Css 3compartmentss Human 95% 3.336 mg/L 1.967 mg/L 1.69598373157092 -DTXSID8041909 Css 3compartmentss Human 95% 29.17 mg/L 50.17 mg/L 0.581423161251744 -DTXSID8041951 Css 3compartmentss Human 95% 15.79 mg/L 12.06 mg/L 1.30928689883914 -DTXSID8041955 Css 3compartmentss Human 95% 4.132 mg/L 2.833 mg/L 1.45852453229792 -DTXSID8041957 Css 3compartmentss Human 95% 0.581 mg/L 0.3548 mg/L 1.63754227733935 -DTXSID8042002 Css 3compartmentss Human 95% 7.179 mg/L 4.508 mg/L 1.59250221827862 -DTXSID8042006 Css 3compartmentss Human 95% 7.954 mg/L 5.618 mg/L 1.41580633677465 -DTXSID8042137 Css 3compartmentss Human 95% 5.913 mg/L 3.277 mg/L 1.80439426304547 -DTXSID8042181 Css 3compartmentss Human 95% 3.178 mg/L 2.99 mg/L 1.0628762541806 -DTXSID8042187 Css 3compartmentss Human 95% 0.5643 mg/L 0.5187 mg/L 1.08791208791209 -DTXSID8042210 Css 3compartmentss Human 95% 4.038 mg/L 2.73 mg/L 1.47912087912088 -DTXSID8042264 Css 3compartmentss Human 95% 12.67 mg/L 9.553 mg/L 1.32628493666911 -DTXSID8042349 Css 3compartmentss Human 95% 4.88 mg/L 0.01079 mg/L 452.27062094532 -DTXSID8042399 Css 3compartmentss Human 95% 85.6 mg/L 40.08 mg/L 2.13572854291417 -DTXSID8042422 Css 3compartmentss Human 95% 0.7369 mg/L 0.5095 mg/L 1.44631992149166 -DTXSID8042424 Css 3compartmentss Human 95% 544.2 mg/L 313.6 mg/L 1.73533163265306 -DTXSID8042426 Css 3compartmentss Human 95% 5.773 mg/L 3.728 mg/L 1.54855150214592 -DTXSID8042478 Css 3compartmentss Human 95% 19.66 mg/L 5.193 mg/L 3.78586558829193 -DTXSID8042503 Css 3compartmentss Human 95% 2.726 mg/L 2.418 mg/L 1.12737799834574 -DTXSID8042507 Css 3compartmentss Human 95% 4.296 mg/L 2.811 mg/L 1.52828175026681 -DTXSID8042509 Css 3compartmentss Human 95% 24.8 mg/L 14.18 mg/L 1.74894217207334 -DTXSID8042559 Css 3compartmentss Human 95% 0.7245 mg/L 0.4356 mg/L 1.66322314049587 -DTXSID8042632 Css 3compartmentss Human 95% 2.397 mg/L 0.9191 mg/L 2.60798607333261 -DTXSID8043814 Css 3compartmentss Human 95% 96.04 mg/L 38.11 mg/L 2.52007347152978 -DTXSID8043941 Css 3compartmentss Human 95% 5.201 mg/L 3.7 mg/L 1.40567567567568 -DTXSID8044175 Css 3compartmentss Human 95% 0.6221 mg/L 0.439 mg/L 1.41708428246014 -DTXSID8044177 Css 3compartmentss Human 95% 5.577 mg/L 3.628 mg/L 1.53721058434399 -DTXSID8044200 Css 3compartmentss Human 95% 9.288 mg/L 5.751 mg/L 1.6150234741784 -DTXSID8044204 Css 3compartmentss Human 95% 1.211 mg/L 0.001142 mg/L 1060.42031523643 -DTXSID8044206 Css 3compartmentss Human 95% 43.78 mg/L 22.77 mg/L 1.92270531400966 -DTXSID8044208 Css 3compartmentss Human 95% 4.811 mg/L 3.086 mg/L 1.55897602073882 -DTXSID8044252 Css 3compartmentss Human 95% 8.502 mg/L 5.316 mg/L 1.59932279909707 -DTXSID8044381 Css 3compartmentss Human 95% 12.54 mg/L 7.493 mg/L 1.67356199119178 -DTXSID8044385 Css 3compartmentss Human 95% 1.24 mg/L 0.8329 mg/L 1.48877416256453 -DTXSID8044389 Css 3compartmentss Human 95% 5.682 mg/L 3.873 mg/L 1.46707978311387 -DTXSID8044410 Css 3compartmentss Human 95% 1.504 mg/L 0.8461 mg/L 1.77756766339676 -DTXSID8044412 Css 3compartmentss Human 95% 5.753 mg/L 3.297 mg/L 1.74491962390052 -DTXSID8044414 Css 3compartmentss Human 95% 27.52 mg/L 15.43 mg/L 1.78353856124433 -DTXSID8044416 Css 3compartmentss Human 95% 5.561 mg/L 3.776 mg/L 1.47272245762712 -DTXSID8044462 Css 3compartmentss Human 95% 7.709 mg/L 3.087 mg/L 2.49724651765468 -DTXSID8044464 Css 3compartmentss Human 95% 30.56 mg/L 16.02 mg/L 1.90761548064919 -DTXSID8044466 Css 3compartmentss Human 95% 8.787 mg/L 5.656 mg/L 1.55357142857143 -DTXSID8044541 Css 3compartmentss Human 95% 9.781 mg/L 9.868 mg/L 0.991183623834617 -DTXSID8044543 Css 3compartmentss Human 95% 2.421 mg/L 1.401 mg/L 1.72805139186295 -DTXSID8044549 Css 3compartmentss Human 95% 402 mg/L 997.1 mg/L 0.403169190652893 -DTXSID8044591 Css 3compartmentss Human 95% 0.7429 mg/L 0.4232 mg/L 1.7554347826087 -DTXSID8044593 Css 3compartmentss Human 95% 2.73 mg/L 1.519 mg/L 1.79723502304147 -DTXSID8044595 Css 3compartmentss Human 95% 2.482 mg/L 0.8803 mg/L 2.81949335453823 -DTXSID8044597 Css 3compartmentss Human 95% 34.95 mg/L 6.693 mg/L 5.22187359928283 -DTXSID8044620 Css 3compartmentss Human 95% 0.01812 mg/L 0.01116 mg/L 1.62365591397849 -DTXSID8044622 Css 3compartmentss Human 95% 0.441 mg/L 2.251e-06 mg/L 195912.927587739 -DTXSID8044626 Css 3compartmentss Human 95% 13.86 mg/L 6.709 mg/L 2.06588165151289 -DTXSID8044670 Css 3compartmentss Human 95% 0.4365 mg/L 0.3096 mg/L 1.40988372093023 -DTXSID8044676 Css 3compartmentss Human 95% 2360 mg/L 4858 mg/L 0.485796624125154 -DTXSID8044678 Css 3compartmentss Human 95% 2.398 mg/L 0.7848 mg/L 3.05555555555556 -DTXSID8044701 Css 3compartmentss Human 95% 0.1939 mg/L 0.1493 mg/L 1.2987273945077 -DTXSID8044703 Css 3compartmentss Human 95% 2.598 mg/L 2.079 mg/L 1.24963924963925 -DTXSID8044709 Css 3compartmentss Human 95% 0.7824 mg/L 0.518 mg/L 1.51042471042471 -DTXSID8044751 Css 3compartmentss Human 95% 7.445 mg/L 4.615 mg/L 1.61321776814735 -DTXSID8044830 Css 3compartmentss Human 95% 1.76 mg/L 1.211 mg/L 1.45334434351775 -DTXSID8044834 Css 3compartmentss Human 95% 3.326 mg/L 2.231 mg/L 1.49081129538324 -DTXSID8044836 Css 3compartmentss Human 95% 9.376 mg/L 4.634 mg/L 2.02330599913681 -DTXSID8044880 Css 3compartmentss Human 95% 7.052 mg/L 4.694 mg/L 1.50234341712825 -DTXSID8044882 Css 3compartmentss Human 95% 2.573 mg/L 1.678 mg/L 1.53337306317044 -DTXSID8044884 Css 3compartmentss Human 95% 7.253 mg/L 5.694 mg/L 1.27379697927643 -DTXSID8044886 Css 3compartmentss Human 95% 53.44 mg/L 31.5 mg/L 1.69650793650794 -DTXSID8044888 Css 3compartmentss Human 95% 11.38 mg/L 6.988 mg/L 1.62850601030338 -DTXSID8044911 Css 3compartmentss Human 95% 12.53 mg/L 4.045 mg/L 3.09765142150803 -DTXSID8044913 Css 3compartmentss Human 95% 0.5679 mg/L 0.1844 mg/L 3.07971800433839 -DTXSID8044915 Css 3compartmentss Human 95% 0.8251 mg/L 0.5871 mg/L 1.40538238800886 -DTXSID8044919 Css 3compartmentss Human 95% 7.778 mg/L 4.407 mg/L 1.76491944633538 -DTXSID8044961 Css 3compartmentss Human 95% 6.335 mg/L 4.303 mg/L 1.47222867766674 -DTXSID8044963 Css 3compartmentss Human 95% 28.54 mg/L 16.38 mg/L 1.74236874236874 -DTXSID8044967 Css 3compartmentss Human 95% 4.806 mg/L 3.154 mg/L 1.52377932783767 -DTXSID8045141 Css 3compartmentss Human 95% 0.03442 mg/L 0.02363 mg/L 1.45662293694456 -DTXSID8045145 Css 3compartmentss Human 95% 0.7491 mg/L 0.07865 mg/L 9.52447552447553 -DTXSID8045147 Css 3compartmentss Human 95% 1.489 mg/L 0.9378 mg/L 1.58775858391981 -DTXSID8045149 Css 3compartmentss Human 95% 1.241 mg/L 0.9475 mg/L 1.30976253298153 -DTXSID8045191 Css 3compartmentss Human 95% 1.012 mg/L 0.4898 mg/L 2.06614944875459 -DTXSID8045193 Css 3compartmentss Human 95% 5.632 mg/L 2.043 mg/L 2.75673029858052 -DTXSID8045195 Css 3compartmentss Human 95% 1.272 mg/L 0.9795 mg/L 1.29862174578867 -DTXSID8045220 Css 3compartmentss Human 95% 0.7 mg/L 0.4268 mg/L 1.64011246485473 -DTXSID8045222 Css 3compartmentss Human 95% 0.3102 mg/L 0.1715 mg/L 1.80874635568513 -DTXSID8045224 Css 3compartmentss Human 95% 72.88 mg/L 41.07 mg/L 1.7745312880448 -DTXSID8045228 Css 3compartmentss Human 95% 24.31 mg/L 12.53 mg/L 1.94014365522745 -DTXSID8045305 Css 3compartmentss Human 95% 12.81 mg/L 7.064 mg/L 1.8134201585504 -DTXSID8045307 Css 3compartmentss Human 95% 18.99 mg/L 10.78 mg/L 1.76159554730983 -DTXSID8045351 Css 3compartmentss Human 95% 4.432 mg/L 2.44 mg/L 1.81639344262295 -DTXSID8045355 Css 3compartmentss Human 95% 17.49 mg/L 10.47 mg/L 1.67048710601719 -DTXSID8045357 Css 3compartmentss Human 95% 1.511 mg/L 0.316 mg/L 4.78164556962025 -DTXSID8045359 Css 3compartmentss Human 95% 1.489 mg/L 0.0654 mg/L 22.7675840978593 -DTXSID8045432 Css 3compartmentss Human 95% 0.1224 mg/L 0.08194 mg/L 1.49377593360996 -DTXSID8045434 Css 3compartmentss Human 95% 0.4399 mg/L 0.2787 mg/L 1.578399712953 -DTXSID8045438 Css 3compartmentss Human 95% 1.272 mg/L 0.8512 mg/L 1.49436090225564 -DTXSID8045480 Css 3compartmentss Human 95% 5.459 mg/L 3.307 mg/L 1.65074085273662 -DTXSID8045484 Css 3compartmentss Human 95% 0.4847 mg/L 0.3092 mg/L 1.56759379042691 -DTXSID8045486 Css 3compartmentss Human 95% 214.3 mg/L 121.7 mg/L 1.76088742810189 -DTXSID8045488 Css 3compartmentss Human 95% 38.32 mg/L 22.36 mg/L 1.71377459749553 -DTXSID8045511 Css 3compartmentss Human 95% 30.8 mg/L 14.14 mg/L 2.17821782178218 -DTXSID8045513 Css 3compartmentss Human 95% 6.594 mg/L 3.455 mg/L 1.90853835021708 -DTXSID8045515 Css 3compartmentss Human 95% 0.004229 mg/L 0.003089 mg/L 1.3690514729686 -DTXSID8045519 Css 3compartmentss Human 95% 1.459 mg/L 1.018 mg/L 1.43320235756385 -DTXSID8045561 Css 3compartmentss Human 95% 2.283 mg/L 1.338 mg/L 1.70627802690583 -DTXSID8045563 Css 3compartmentss Human 95% 0.9917 mg/L 0.1194 mg/L 8.30569514237856 -DTXSID8045565 Css 3compartmentss Human 95% 0.5412 mg/L 0.003926 mg/L 137.850229240958 -DTXSID8045567 Css 3compartmentss Human 95% 39.82 mg/L 20.92 mg/L 1.90344168260038 -DTXSID8045569 Css 3compartmentss Human 95% 0.5826 mg/L 0.1572 mg/L 3.70610687022901 -DTXSID8045640 Css 3compartmentss Human 95% 0.4552 mg/L 0.1983 mg/L 2.29551185073122 -DTXSID8045642 Css 3compartmentss Human 95% 3.204 mg/L 2.054 mg/L 1.55988315481986 -DTXSID8045646 Css 3compartmentss Human 95% 22.41 mg/L 13.11 mg/L 1.70938215102975 -DTXSID8045648 Css 3compartmentss Human 95% 1.586 mg/L 1.041 mg/L 1.52353506243996 -DTXSID8045690 Css 3compartmentss Human 95% 0.2625 mg/L 0.1334 mg/L 1.96776611694153 -DTXSID8045692 Css 3compartmentss Human 95% 1.352 mg/L 0.8204 mg/L 1.64797659678206 -DTXSID8045694 Css 3compartmentss Human 95% 627 mg/L 365.7 mg/L 1.71452009844135 -DTXSID8045696 Css 3compartmentss Human 95% 7.534 mg/L 4.765 mg/L 1.58111227701994 -DTXSID8045698 Css 3compartmentss Human 95% 7.301 mg/L 4.059 mg/L 1.79871889627987 -DTXSID8045771 Css 3compartmentss Human 95% 58.06 mg/L 36.82 mg/L 1.57686040195546 -DTXSID8045773 Css 3compartmentss Human 95% 0.5071 mg/L 0.4163 mg/L 1.21811193850589 -DTXSID8045775 Css 3compartmentss Human 95% 52.61 mg/L 24.42 mg/L 2.15438165438165 -DTXSID8045777 Css 3compartmentss Human 95% 7.593 mg/L 4.746 mg/L 1.59987357774968 -DTXSID8045779 Css 3compartmentss Human 95% 6.966 mg/L 4.65 mg/L 1.49806451612903 -DTXSID8045800 Css 3compartmentss Human 95% 0.03194 mg/L 0.01779 mg/L 1.79539066891512 -DTXSID8045802 Css 3compartmentss Human 95% 1.154 mg/L 0.1091 mg/L 10.5774518790101 -DTXSID8045804 Css 3compartmentss Human 95% 4.345 mg/L 0.02179 mg/L 199.403396053235 -DTXSID8045806 Css 3compartmentss Human 95% 1.733 mg/L 0.6988 mg/L 2.47996565540927 -DTXSID8045850 Css 3compartmentss Human 95% 5.658 mg/L 3.307 mg/L 1.71091623828243 -DTXSID8045852 Css 3compartmentss Human 95% 3.244 mg/L 2.09 mg/L 1.55215311004785 -DTXSID8045854 Css 3compartmentss Human 95% 2.011 mg/L 0.8083 mg/L 2.48793764691328 -DTXSID8045856 Css 3compartmentss Human 95% 8.96 mg/L 6.293 mg/L 1.4238042269188 -DTXSID8045933 Css 3compartmentss Human 95% 0.3678 mg/L 0.2891 mg/L 1.27222414389485 -DTXSID8045935 Css 3compartmentss Human 95% 1.379 mg/L 0.8359 mg/L 1.64971886589305 -DTXSID8045937 Css 3compartmentss Human 95% 103 mg/L 55.71 mg/L 1.84886016873093 -DTXSID8045939 Css 3compartmentss Human 95% 0.8533 mg/L 0.5466 mg/L 1.56110501280644 -DTXSID8045983 Css 3compartmentss Human 95% 4.963 mg/L 3.01 mg/L 1.64883720930233 -DTXSID8045985 Css 3compartmentss Human 95% 1.14 mg/L 0.6613 mg/L 1.723877211553 -DTXSID8045987 Css 3compartmentss Human 95% 5.738 mg/L 3.628 mg/L 1.58158765159868 -DTXSID8045989 Css 3compartmentss Human 95% 1.881 mg/L 1.633 mg/L 1.15186772810778 -DTXSID8046030 Css 3compartmentss Human 95% 7.226 mg/L 4.443 mg/L 1.62637857303624 -DTXSID8046034 Css 3compartmentss Human 95% 6.911 mg/L 4.408 mg/L 1.56783121597096 -DTXSID8046036 Css 3compartmentss Human 95% 4.689 mg/L 1.657 mg/L 2.82981291490646 -DTXSID8046038 Css 3compartmentss Human 95% 0.6842 mg/L 0.4264 mg/L 1.60459662288931 -DTXSID8046084 Css 3compartmentss Human 95% 7.544 mg/L 4.643 mg/L 1.62481154426018 -DTXSID8046086 Css 3compartmentss Human 95% 1.669 mg/L 1.087 mg/L 1.53541858325667 -DTXSID8046088 Css 3compartmentss Human 95% 8.633 mg/L 1.628 mg/L 5.30282555282555 -DTXSID8046113 Css 3compartmentss Human 95% 1.077 mg/L 0.7314 mg/L 1.47251845775226 -DTXSID8046117 Css 3compartmentss Human 95% 3.996 mg/L 3.129 mg/L 1.27708533077661 -DTXSID8046119 Css 3compartmentss Human 95% 0.2997 mg/L 0.1707 mg/L 1.75571177504394 -DTXSID8046161 Css 3compartmentss Human 95% 5.616 mg/L 3.224 mg/L 1.74193548387097 -DTXSID8046163 Css 3compartmentss Human 95% 1.908 mg/L 1.077 mg/L 1.77158774373259 -DTXSID8046165 Css 3compartmentss Human 95% 2.977 mg/L 2.311 mg/L 1.28818693206404 -DTXSID8046169 Css 3compartmentss Human 95% 0.001595 mg/L 0 mg/L Inf -DTXSID8046240 Css 3compartmentss Human 95% 22.12 mg/L 11.67 mg/L 1.89545844044559 -DTXSID8046242 Css 3compartmentss Human 95% 2.792 mg/L 1.276 mg/L 2.18808777429467 -DTXSID8046244 Css 3compartmentss Human 95% 433.2 mg/L 240.1 mg/L 1.80424822990421 -DTXSID8046246 Css 3compartmentss Human 95% 0.3848 mg/L 0.2236 mg/L 1.72093023255814 -DTXSID8046248 Css 3compartmentss Human 95% 0.05429 mg/L 0.003708 mg/L 14.6413160733549 -DTXSID8046290 Css 3compartmentss Human 95% 6.305 mg/L 4.079 mg/L 1.54572199068399 -DTXSID8046292 Css 3compartmentss Human 95% 58.85 mg/L 34.66 mg/L 1.69792267743797 -DTXSID8046294 Css 3compartmentss Human 95% 3.751 mg/L 1.516 mg/L 2.47427440633245 -DTXSID8046296 Css 3compartmentss Human 95% 2.035 mg/L 0.5927 mg/L 3.43344018896575 -DTXSID8046298 Css 3compartmentss Human 95% 1.754 mg/L 2.145 mg/L 0.817715617715618 -DTXSID8046321 Css 3compartmentss Human 95% 3.407 mg/L 2.633 mg/L 1.2939612609191 -DTXSID8046323 Css 3compartmentss Human 95% 0.7883 mg/L 0.4615 mg/L 1.70812567713976 -DTXSID8046325 Css 3compartmentss Human 95% 1.733 mg/L 1.222 mg/L 1.41816693944354 -DTXSID8046327 Css 3compartmentss Human 95% 1.732 mg/L 1.186 mg/L 1.46037099494098 -DTXSID8046400 Css 3compartmentss Human 95% 0.1686 mg/L 0.0004751 mg/L 354.872658387708 -DTXSID8046402 Css 3compartmentss Human 95% 1.404 mg/L 0.825 mg/L 1.70181818181818 -DTXSID8046404 Css 3compartmentss Human 95% 0.9946 mg/L 0.6381 mg/L 1.55868986052343 -DTXSID8046406 Css 3compartmentss Human 95% 12.32 mg/L 6.193 mg/L 1.98934280639432 -DTXSID8046450 Css 3compartmentss Human 95% 5.823 mg/L 1.85e-07 mg/L 31475675.6756757 -DTXSID8046452 Css 3compartmentss Human 95% 6.427 mg/L 1.27 mg/L 5.06062992125984 -DTXSID8046454 Css 3compartmentss Human 95% 0.3323 mg/L 0.1894 mg/L 1.7544878563886 -DTXSID8046456 Css 3compartmentss Human 95% 0.3405 mg/L 0.02704 mg/L 12.5924556213018 -DTXSID8046458 Css 3compartmentss Human 95% 7.297 mg/L 0.3241 mg/L 22.5146559703795 -DTXSID8046531 Css 3compartmentss Human 95% 2.487 mg/L 1.842 mg/L 1.35016286644951 -DTXSID8046537 Css 3compartmentss Human 95% NA mg/L NA NA NA -DTXSID8046539 Css 3compartmentss Human 95% 9.204 mg/L 5.591 mg/L 1.64621713468074 -DTXSID8046581 Css 3compartmentss Human 95% 6.808 mg/L 4.673 mg/L 1.45687994864113 -DTXSID8046583 Css 3compartmentss Human 95% NA mg/L NA NA NA -DTXSID8046585 Css 3compartmentss Human 95% 55.97 mg/L 30.07 mg/L 1.86132357831726 -DTXSID8046589 Css 3compartmentss Human 95% 51.81 mg/L 3.963 mg/L 13.0734292202877 -DTXSID8046610 Css 3compartmentss Human 95% 4.867 mg/L 5.601 mg/L 0.868951972861989 -DTXSID8046618 Css 3compartmentss Human 95% 0.5458 mg/L 0.3328 mg/L 1.64002403846154 -DTXSID8046660 Css 3compartmentss Human 95% 8.548 mg/L 5.257 mg/L 1.62602244626213 -DTXSID8046662 Css 3compartmentss Human 95% 4.124 mg/L 2.256 mg/L 1.82801418439716 -DTXSID8046664 Css 3compartmentss Human 95% 1.508 mg/L 1.617 mg/L 0.932591218305504 -DTXSID8046666 Css 3compartmentss Human 95% 1.499 mg/L 0.197 mg/L 7.60913705583756 -DTXSID8046743 Css 3compartmentss Human 95% 16.75 mg/L 5.012 mg/L 3.34197924980048 -DTXSID8046749 Css 3compartmentss Human 95% 0.02362 mg/L 0 mg/L Inf -DTXSID8046791 Css 3compartmentss Human 95% 3.582 mg/L 1.394 mg/L 2.56958393113343 -DTXSID8046793 Css 3compartmentss Human 95% 0.03524 mg/L 0.02307 mg/L 1.52752492414391 -DTXSID8046795 Css 3compartmentss Human 95% 3.214 mg/L 3.406 mg/L 0.943628890193776 -DTXSID8046799 Css 3compartmentss Human 95% 9.605 mg/L 5.9 mg/L 1.62796610169492 -DTXSID8046820 Css 3compartmentss Human 95% 4.043 mg/L 8.4e-07 mg/L 4813095.23809524 -DTXSID8046822 Css 3compartmentss Human 95% 24.3 mg/L 2.12 mg/L 11.4622641509434 -DTXSID8046824 Css 3compartmentss Human 95% 5.487 mg/L 3.407 mg/L 1.6105077781039 -DTXSID8046826 Css 3compartmentss Human 95% 8.948 mg/L 5.443 mg/L 1.64394635311409 -DTXSID8046828 Css 3compartmentss Human 95% 7.718 mg/L 4.728 mg/L 1.6324027072758 -DTXSID8046870 Css 3compartmentss Human 95% 0.6366 mg/L 0.3924 mg/L 1.62232415902141 -DTXSID8046872 Css 3compartmentss Human 95% 13.46 mg/L 4.834 mg/L 2.78444352503103 -DTXSID8046876 Css 3compartmentss Human 95% 0.02038 mg/L 0.0119 mg/L 1.71260504201681 -DTXSID8046878 Css 3compartmentss Human 95% 5.637 mg/L 3.674 mg/L 1.53429504627109 -DTXSID8046901 Css 3compartmentss Human 95% 0.01697 mg/L 0.0088 mg/L 1.92840909090909 -DTXSID8046903 Css 3compartmentss Human 95% 20.29 mg/L 32.51 mg/L 0.624115656721009 -DTXSID8046905 Css 3compartmentss Human 95% 570.4 mg/L 288.9 mg/L 1.97438560055382 -DTXSID8046909 Css 3compartmentss Human 95% 7.234 mg/L 4.61 mg/L 1.56919739696312 -DTXSID8046951 Css 3compartmentss Human 95% 2.357 mg/L 0.6246 mg/L 3.77361511367275 -DTXSID8047006 Css 3compartmentss Human 95% 103.3 mg/L 63.56 mg/L 1.62523599748269 -DTXSID8047056 Css 3compartmentss Human 95% 0.02624 mg/L 1e-09 mg/L 26240000 -DTXSID8047058 Css 3compartmentss Human 95% 0.4723 mg/L 0.3281 mg/L 1.43950015239256 -DTXSID8047137 Css 3compartmentss Human 95% 9.78 mg/L 5.407 mg/L 1.8087664139079 -DTXSID8047183 Css 3compartmentss Human 95% 37.9 mg/L 22.39 mg/L 1.69271996426976 -DTXSID8047218 Css 3compartmentss Human 95% 7.704 mg/L 4.815 mg/L 1.6 -DTXSID8047262 Css 3compartmentss Human 95% 620 mg/L 365.8 mg/L 1.69491525423729 -DTXSID8047264 Css 3compartmentss Human 95% 56.72 mg/L 33.8 mg/L 1.67810650887574 -DTXSID8047266 Css 3compartmentss Human 95% 5.036 mg/L 2.973 mg/L 1.69391187352842 -DTXSID8047268 Css 3compartmentss Human 95% 66.01 mg/L 31.58 mg/L 2.09024699176694 -DTXSID8047341 Css 3compartmentss Human 95% 19.63 mg/L 0.0278 mg/L 706.115107913669 -DTXSID8047347 Css 3compartmentss Human 95% 1.754 mg/L 0.375 mg/L 4.67733333333333 -DTXSID8047349 Css 3compartmentss Human 95% 13.58 mg/L 7.021 mg/L 1.93419740777667 -DTXSID8047391 Css 3compartmentss Human 95% 12.32 mg/L 6.79 mg/L 1.81443298969072 -DTXSID8047395 Css 3compartmentss Human 95% 0.02957 mg/L 0 mg/L Inf -DTXSID8047397 Css 3compartmentss Human 95% 0.392 mg/L 0.1959 mg/L 2.00102092904543 -DTXSID8047420 Css 3compartmentss Human 95% 0.8851 mg/L 0.6156 mg/L 1.43778427550357 -DTXSID8047428 Css 3compartmentss Human 95% 0.3052 mg/L 0.2528 mg/L 1.20727848101266 -DTXSID8047470 Css 3compartmentss Human 95% 0.1245 mg/L 0.07909 mg/L 1.57415602478189 -DTXSID8047501 Css 3compartmentss Human 95% 0.3428 mg/L 0.0192 mg/L 17.8541666666667 -DTXSID8047505 Css 3compartmentss Human 95% 174.8 mg/L 286.8 mg/L 0.609483960948396 -DTXSID8047551 Css 3compartmentss Human 95% 25.07 mg/L 40.09 mg/L 0.625342978298828 -DTXSID8047553 Css 3compartmentss Human 95% 14040 mg/L 7919 mg/L 1.77295113019321 -DTXSID8047630 Css 3compartmentss Human 95% 0.02272 mg/L 0.01626 mg/L 1.39729397293973 -DTXSID8047680 Css 3compartmentss Human 95% 1.719 mg/L 1.247 mg/L 1.3785084202085 -DTXSID8047686 Css 3compartmentss Human 95% 18.07 mg/L 7.304 mg/L 2.47398685651698 -DTXSID8047711 Css 3compartmentss Human 95% 5.58e-07 mg/L NA NA NA -DTXSID8047713 Css 3compartmentss Human 95% 0.2206 mg/L 0.1814 mg/L 1.21609702315325 -DTXSID8047717 Css 3compartmentss Human 95% 3.906 mg/L 1.579 mg/L 2.47371754274858 -DTXSID8047840 Css 3compartmentss Human 95% 0.02741 mg/L 0.01561 mg/L 1.75592568866111 -DTXSID8047842 Css 3compartmentss Human 95% 0.6074 mg/L 0.3675 mg/L 1.65278911564626 -DTXSID8047844 Css 3compartmentss Human 95% 5.156 mg/L 3.842 mg/L 1.34200937011973 -DTXSID8047846 Css 3compartmentss Human 95% 8.569 mg/L 4.678 mg/L 1.83176571184267 -DTXSID8047848 Css 3compartmentss Human 95% 1.178 mg/L 0.8933 mg/L 1.31870592186276 -DTXSID8047890 Css 3compartmentss Human 95% 2.001 mg/L 1.095 mg/L 1.82739726027397 -DTXSID8047894 Css 3compartmentss Human 95% 5.87 mg/L 2.904 mg/L 2.02134986225895 -DTXSID8047896 Css 3compartmentss Human 95% 39.72 mg/L 0.01028 mg/L 3863.81322957198 -DTXSID8047898 Css 3compartmentss Human 95% 7.712 mg/L 4.872 mg/L 1.58292282430213 -DTXSID8047923 Css 3compartmentss Human 95% 1.774 mg/L 0.03914 mg/L 45.3244762391415 -DTXSID8047927 Css 3compartmentss Human 95% 4.372 mg/L 2.897 mg/L 1.50914739385571 -DTXSID8047973 Css 3compartmentss Human 95% 3.862 mg/L 0.8906 mg/L 4.33640242533124 -DTXSID8048494 Css 3compartmentss Human 95% 0.8533 mg/L 0.5466 mg/L 1.56110501280644 -DTXSID8048521 Css 3compartmentss Human 95% 0.9079 mg/L 0.3597 mg/L 2.5240478176258 -DTXSID8048575 Css 3compartmentss Human 95% 0.162 mg/L 0.1071 mg/L 1.51260504201681 -DTXSID8048577 Css 3compartmentss Human 95% 4.368 mg/L 2.233 mg/L 1.95611285266458 -DTXSID8048579 Css 3compartmentss Human 95% 0.3584 mg/L 0.1982 mg/L 1.80827447023209 -DTXSID8048600 Css 3compartmentss Human 95% 3.541 mg/L 0.8059 mg/L 4.39384539024693 -DTXSID8048602 Css 3compartmentss Human 95% 0.3012 mg/L 0.2266 mg/L 1.32921447484554 -DTXSID8048604 Css 3compartmentss Human 95% 0.00708 mg/L 0.005517 mg/L 1.28330614464383 -DTXSID8048606 Css 3compartmentss Human 95% 16.86 mg/L 8.859 mg/L 1.90314933965459 -DTXSID8048608 Css 3compartmentss Human 95% 17.12 mg/L 4.506 mg/L 3.79937860630271 -DTXSID8048650 Css 3compartmentss Human 95% 53.12 mg/L 28.9 mg/L 1.83806228373702 -DTXSID8048652 Css 3compartmentss Human 95% 165.4 mg/L 5.109 mg/L 32.3742415345469 -DTXSID8048654 Css 3compartmentss Human 95% 1.716 mg/L 0.4333 mg/L 3.96030463881837 -DTXSID8048656 Css 3compartmentss Human 95% 0.8648 mg/L 0.2361 mg/L 3.66285472257518 -DTXSID8048658 Css 3compartmentss Human 95% 14.18 mg/L 7.45 mg/L 1.90335570469799 -DTXSID8048731 Css 3compartmentss Human 95% 12.01 mg/L 0.05278 mg/L 227.54831375521 -DTXSID8048733 Css 3compartmentss Human 95% 7.722 mg/L 3.1 mg/L 2.49096774193548 -DTXSID8048735 Css 3compartmentss Human 95% 2.283 mg/L 1.287 mg/L 1.77389277389277 -DTXSID8048737 Css 3compartmentss Human 95% 6.911 mg/L 3.687 mg/L 1.8744236506645 -DTXSID8048739 Css 3compartmentss Human 95% 5.505 mg/L 3.307 mg/L 1.66465074085274 -DTXSID8048781 Css 3compartmentss Human 95% 8.939 mg/L 1.731 mg/L 5.16406701328712 -DTXSID8048783 Css 3compartmentss Human 95% 256.8 mg/L 147.9 mg/L 1.73630831643002 -DTXSID8048785 Css 3compartmentss Human 95% 222.2 mg/L 68.22 mg/L 3.25710935209616 -DTXSID8048787 Css 3compartmentss Human 95% 96.71 mg/L 53.18 mg/L 1.81854080481384 -DTXSID8048789 Css 3compartmentss Human 95% 3.224 mg/L 1.954 mg/L 1.64994882292733 -DTXSID8048810 Css 3compartmentss Human 95% 4.897 mg/L 3.742 mg/L 1.30865847140567 -DTXSID8048812 Css 3compartmentss Human 95% 0.6572 mg/L 0.2729 mg/L 2.40820813484793 -DTXSID8048814 Css 3compartmentss Human 95% 5.592 mg/L 2.985 mg/L 1.87336683417085 -DTXSID8048816 Css 3compartmentss Human 95% 1.291 mg/L 1.232 mg/L 1.04788961038961 -DTXSID8048818 Css 3compartmentss Human 95% 6.019 mg/L 2.396 mg/L 2.51210350584307 -DTXSID8048860 Css 3compartmentss Human 95% 6.124 mg/L 7.017 mg/L 0.87273763716688 -DTXSID8048862 Css 3compartmentss Human 95% 6.139 mg/L 3.943 mg/L 1.55693634288613 -DTXSID8048864 Css 3compartmentss Human 95% 0.372 mg/L 0.2673 mg/L 1.39169472502806 -DTXSID8048866 Css 3compartmentss Human 95% 1.519 mg/L 1.241 mg/L 1.22401289282836 -DTXSID8048868 Css 3compartmentss Human 95% 0.3296 mg/L 0.2178 mg/L 1.51331496786042 -DTXSID8048941 Css 3compartmentss Human 95% 0.6429 mg/L 0.4713 mg/L 1.36409929980904 -DTXSID8048943 Css 3compartmentss Human 95% 8.153 mg/L 2.959 mg/L 2.75532274417033 -DTXSID8048945 Css 3compartmentss Human 95% 42.84 mg/L 15.82 mg/L 2.70796460176991 -DTXSID8048947 Css 3compartmentss Human 95% 138.4 mg/L 25.34 mg/L 5.46172059984215 -DTXSID8048949 Css 3compartmentss Human 95% 0.1745 mg/L 0.1074 mg/L 1.62476722532588 -DTXSID8048991 Css 3compartmentss Human 95% 0.03675 mg/L 0.02468 mg/L 1.48905996758509 -DTXSID8048995 Css 3compartmentss Human 95% 3.829 mg/L 2.234 mg/L 1.71396598030439 -DTXSID8048997 Css 3compartmentss Human 95% 3.733 mg/L 4.096 mg/L 0.911376953125 -DTXSID8048999 Css 3compartmentss Human 95% 8.837 mg/L 3.876 mg/L 2.27992776057792 -DTXSID8049040 Css 3compartmentss Human 95% 1.792 mg/L 0.6209 mg/L 2.88613303269448 -DTXSID8049042 Css 3compartmentss Human 95% 2.973 mg/L 2.172 mg/L 1.36878453038674 -DTXSID8049044 Css 3compartmentss Human 95% 33.37 mg/L 18.5 mg/L 1.80378378378378 -DTXSID8049046 Css 3compartmentss Human 95% 34.58 mg/L 0.7493 mg/L 46.1497397571066 -DTXSID8049048 Css 3compartmentss Human 95% 8.556 mg/L 1.255 mg/L 6.81752988047809 -DTXSID8049200 Css 3compartmentss Human 95% 18.35 mg/L 27.08 mg/L 0.677621861152142 -DTXSID8049202 Css 3compartmentss Human 95% 8.489 mg/L 3.812 mg/L 2.22691500524659 -DTXSID8049206 Css 3compartmentss Human 95% 6.138 mg/L 3.939 mg/L 1.55826351865956 -DTXSID8049208 Css 3compartmentss Human 95% 1.945 mg/L 1.375 mg/L 1.41454545454545 -DTXSID8049250 Css 3compartmentss Human 95% 1.613 mg/L 0.0336 mg/L 48.0059523809524 -DTXSID8049254 Css 3compartmentss Human 95% 1.774 mg/L 0.03914 mg/L 45.3244762391415 -DTXSID8049331 Css 3compartmentss Human 95% 6.67 mg/L 3.987 mg/L 1.67293704539754 -DTXSID8049333 Css 3compartmentss Human 95% 2.326 mg/L 0.2671 mg/L 8.7083489329839 -DTXSID8049337 Css 3compartmentss Human 95% 6.016 mg/L 3.938 mg/L 1.52767902488573 -DTXSID8049381 Css 3compartmentss Human 95% 3.277 mg/L 2.18 mg/L 1.50321100917431 -DTXSID8049383 Css 3compartmentss Human 95% 1.366 mg/L 0.8516 mg/L 1.60403945514326 -DTXSID8049387 Css 3compartmentss Human 95% 79.26 mg/L 9739 mg/L 0.00813841256802546 -DTXSID8049410 Css 3compartmentss Human 95% 1.758 mg/L 1.093 mg/L 1.60841720036597 -DTXSID8049412 Css 3compartmentss Human 95% 4.641 mg/L 2.9 mg/L 1.60034482758621 -DTXSID8049414 Css 3compartmentss Human 95% 15.28 mg/L 8.015 mg/L 1.90642545227698 -DTXSID8049416 Css 3compartmentss Human 95% 2.213 mg/L 1.317 mg/L 1.68033409263478 -DTXSID8049418 Css 3compartmentss Human 95% 5.13 mg/L 4.317 mg/L 1.18832522585129 -DTXSID8051544 Css 3compartmentss Human 95% 3.566 mg/L 2.386 mg/L 1.49455155071249 -DTXSID8051629 Css 3compartmentss Human 95% 5.53 mg/L 3.155 mg/L 1.75277337559429 -DTXSID8051704 Css 3compartmentss Human 95% 0.2254 mg/L 0.008054 mg/L 27.9860938664018 -DTXSID8051708 Css 3compartmentss Human 95% 5.472 mg/L 4.46 mg/L 1.22690582959641 -DTXSID8051754 Css 3compartmentss Human 95% 9.613 mg/L 8.284 mg/L 1.16042974408498 -DTXSID8051914 Css 3compartmentss Human 95% 0.97 mg/L 0.4561 mg/L 2.12672659504495 -DTXSID8052300 Css 3compartmentss Human 95% 1.268 mg/L 0.8109 mg/L 1.56369466025404 -DTXSID8052308 Css 3compartmentss Human 95% 5.519 mg/L 3.357 mg/L 1.64402740542151 -DTXSID8052641 Css 3compartmentss Human 95% 13.37 mg/L 11.17 mg/L 1.19695613249776 -DTXSID8052724 Css 3compartmentss Human 95% 25.24 mg/L 14.67 mg/L 1.72051806407635 -DTXSID8057641 Css 3compartmentss Human 95% 49.88 mg/L 0.3707 mg/L 134.556244942002 -DTXSID8057643 Css 3compartmentss Human 95% 1.293 mg/L 0.1895 mg/L 6.82321899736148 -DTXSID8057645 Css 3compartmentss Human 95% 0.7635 mg/L 0.4272 mg/L 1.7872191011236 -DTXSID8057647 Css 3compartmentss Human 95% 42.8 mg/L 1.165 mg/L 36.7381974248927 -DTXSID8057649 Css 3compartmentss Human 95% 12.4 mg/L 1.047 mg/L 11.8433619866285 -DTXSID8057691 Css 3compartmentss Human 95% 33.26 mg/L 19.06 mg/L 1.74501573976915 -DTXSID8057693 Css 3compartmentss Human 95% 922.2 mg/L 533.5 mg/L 1.72858481724461 -DTXSID8057695 Css 3compartmentss Human 95% 14.62 mg/L 7.243 mg/L 2.01850062128952 -DTXSID8057697 Css 3compartmentss Human 95% 0.9785 mg/L 0.005868 mg/L 166.75187457396 -DTXSID8057699 Css 3compartmentss Human 95% 0.8819 mg/L 0.4608 mg/L 1.91384548611111 -DTXSID8057720 Css 3compartmentss Human 95% 0.13 mg/L 0.09106 mg/L 1.4276301339776 -DTXSID8057722 Css 3compartmentss Human 95% 0.03237 mg/L 0.02084 mg/L 1.55326295585413 -DTXSID8057724 Css 3compartmentss Human 95% 0.4762 mg/L 0.2957 mg/L 1.61041596212377 -DTXSID8057726 Css 3compartmentss Human 95% 0.1737 mg/L 0.1227 mg/L 1.41564792176039 -DTXSID8057728 Css 3compartmentss Human 95% 12.74 mg/L 10.89 mg/L 1.16988062442608 -DTXSID8057770 Css 3compartmentss Human 95% 1.249 mg/L 0.8895 mg/L 1.40415964024733 -DTXSID8057772 Css 3compartmentss Human 95% 131.7 mg/L 71.25 mg/L 1.84842105263158 -DTXSID8057774 Css 3compartmentss Human 95% 0.3132 mg/L 0.195 mg/L 1.60615384615385 -DTXSID8057776 Css 3compartmentss Human 95% 3.643 mg/L 2.143 mg/L 1.69995333644424 -DTXSID8057778 Css 3compartmentss Human 95% 64.22 mg/L 18.67 mg/L 3.43974290305303 -DTXSID8057801 Css 3compartmentss Human 95% 3.15 mg/L 1.741 mg/L 1.80930499712809 -DTXSID8057803 Css 3compartmentss Human 95% 0.1983 mg/L 0.11 mg/L 1.80272727272727 -DTXSID8057805 Css 3compartmentss Human 95% 22.85 mg/L 12.92 mg/L 1.76857585139319 -DTXSID8057807 Css 3compartmentss Human 95% 1.052 mg/L 0.696 mg/L 1.51149425287356 -DTXSID8057809 Css 3compartmentss Human 95% 24.93 mg/L 13.9 mg/L 1.79352517985612 -DTXSID8057851 Css 3compartmentss Human 95% 0.9774 mg/L 0.3952 mg/L 2.47317813765182 -DTXSID8057853 Css 3compartmentss Human 95% 60.14 mg/L 34.48 mg/L 1.74419953596288 -DTXSID8057855 Css 3compartmentss Human 95% 0.671 mg/L 0.5103 mg/L 1.31491279639428 -DTXSID8057857 Css 3compartmentss Human 95% 1.803 mg/L 0.6417 mg/L 2.80972417017298 -DTXSID901017944 Css 3compartmentss Human 95% 262 mg/L 156.7 mg/L 1.67198468410976 -DTXSID90185198 Css 3compartmentss Human 95% 19.39 mg/L 10.89 mg/L 1.78053259871442 -DTXSID9020031 Css 3compartmentss Human 95% 0.03425 mg/L 0.02659 mg/L 1.28807822489658 -DTXSID9020035 Css 3compartmentss Human 95% 2.515 mg/L 1.33 mg/L 1.89097744360902 -DTXSID9020081 Css 3compartmentss Human 95% 6.678 mg/L 6.677 mg/L 1.00014976785982 -DTXSID9020087 Css 3compartmentss Human 95% 0.4203 mg/L 0.3442 mg/L 1.22109238814643 -DTXSID9020089 Css 3compartmentss Human 95% 7.753 mg/L 2.615 mg/L 2.96481835564053 -DTXSID9020110 Css 3compartmentss Human 95% 1.42 mg/L 0.00463 mg/L 306.695464362851 -DTXSID9020112 Css 3compartmentss Human 95% 41.08 mg/L 34.05 mg/L 1.2064610866373 -DTXSID9020114 Css 3compartmentss Human 95% 2.049 mg/L 1.094 mg/L 1.87294332723949 -DTXSID9020116 Css 3compartmentss Human 95% 5.395 mg/L 3.628 mg/L 1.48704520396913 -DTXSID9020118 Css 3compartmentss Human 95% 5.536 mg/L 3.307 mg/L 1.67402479588751 -DTXSID9020160 Css 3compartmentss Human 95% 11240 mg/L 9739 mg/L 1.15412259985625 -DTXSID9020164 Css 3compartmentss Human 95% 7.953 mg/L 5.748 mg/L 1.38361169102296 -DTXSID9020166 Css 3compartmentss Human 95% 8.723e-06 mg/L NA NA NA -DTXSID9020168 Css 3compartmentss Human 95% 2.808 mg/L 1.808 mg/L 1.55309734513274 -DTXSID9020241 Css 3compartmentss Human 95% 11.66 mg/L 7.338 mg/L 1.588988825293 -DTXSID9020243 Css 3compartmentss Human 95% 9.559 mg/L 6.044 mg/L 1.58156849768365 -DTXSID9020245 Css 3compartmentss Human 95% 1.105 mg/L 1.117 mg/L 0.989256938227395 -DTXSID9020247 Css 3compartmentss Human 95% 0.3906 mg/L 0.237 mg/L 1.64810126582278 -DTXSID9020249 Css 3compartmentss Human 95% 7.891 mg/L 5.283 mg/L 1.49365890592466 -DTXSID9020293 Css 3compartmentss Human 95% 1.039 mg/L 0.7832 mg/L 1.32660878447395 -DTXSID9020295 Css 3compartmentss Human 95% 8.806 mg/L 5.912 mg/L 1.48951285520974 -DTXSID9020299 Css 3compartmentss Human 95% 0.8391 mg/L 0.2552 mg/L 3.28800940438871 -DTXSID9020322 Css 3compartmentss Human 95% 19.31 mg/L 10.49 mg/L 1.84080076263108 -DTXSID9020326 Css 3compartmentss Human 95% NA mg/L NA NA NA -DTXSID9020328 Css 3compartmentss Human 95% 40.33 mg/L 20.87 mg/L 1.93243890752276 -DTXSID9020370 Css 3compartmentss Human 95% 0.5163 mg/L 0.3026 mg/L 1.70621282220753 -DTXSID9020372 Css 3compartmentss Human 95% 15.73 mg/L 5.833e-05 mg/L 269672.552717298 -DTXSID9020378 Css 3compartmentss Human 95% 0.9626 mg/L 0.5496 mg/L 1.75145560407569 -DTXSID9020401 Css 3compartmentss Human 95% 0.1755 mg/L 0.105 mg/L 1.67142857142857 -DTXSID9020407 Css 3compartmentss Human 95% 4.2 mg/L 1.436 mg/L 2.92479108635098 -DTXSID9020409 Css 3compartmentss Human 95% 1.562 mg/L 7.772e-06 mg/L 200977.869274318 -DTXSID9020451 Css 3compartmentss Human 95% 23.55 mg/L 23.64 mg/L 0.996192893401015 -DTXSID9020453 Css 3compartmentss Human 95% 2568 mg/L 4550 mg/L 0.564395604395604 -DTXSID9020459 Css 3compartmentss Human 95% 2.322 mg/L 1.809 mg/L 1.28358208955224 -DTXSID9020538 Css 3compartmentss Human 95% 4.215 mg/L 1.724 mg/L 2.44489559164733 -DTXSID9020580 Css 3compartmentss Human 95% 2.067 mg/L 1.309 mg/L 1.5790679908327 -DTXSID9020582 Css 3compartmentss Human 95% 34.03 mg/L 12.18 mg/L 2.79392446633826 -DTXSID9020584 Css 3compartmentss Human 95% 0.2701 mg/L 0.1286 mg/L 2.10031104199067 -DTXSID9020615 Css 3compartmentss Human 95% 84.64 mg/L 38.14 mg/L 2.21919244887257 -DTXSID9020617 Css 3compartmentss Human 95% 0.203 mg/L 0.1533 mg/L 1.32420091324201 -DTXSID9020663 Css 3compartmentss Human 95% 4.979 mg/L 3.264 mg/L 1.52542892156863 -DTXSID9020667 Css 3compartmentss Human 95% 4.22 mg/L 2.783 mg/L 1.51634926338484 -DTXSID9020669 Css 3compartmentss Human 95% 24.45 mg/L 12.13 mg/L 2.0156636438582 -DTXSID9020740 Css 3compartmentss Human 95% 26.26 mg/L 6.274 mg/L 4.1855275741154 -DTXSID9020742 Css 3compartmentss Human 95% 5.424 mg/L 3.758 mg/L 1.44332091538052 -DTXSID9020790 Css 3compartmentss Human 95% 0.08566 mg/L 0.06282 mg/L 1.36357847819166 -DTXSID9020792 Css 3compartmentss Human 95% 3.085 mg/L 2.238 mg/L 1.37846291331546 -DTXSID9020794 Css 3compartmentss Human 95% 2.105 mg/L 1.365 mg/L 1.54212454212454 -DTXSID9020796 Css 3compartmentss Human 95% 1.092 mg/L 0.2198 mg/L 4.96815286624204 -DTXSID9020821 Css 3compartmentss Human 95% 5.533 mg/L 3.307 mg/L 1.67311762927124 -DTXSID9020825 Css 3compartmentss Human 95% 0.9777 mg/L 0.4669 mg/L 2.09402441636325 -DTXSID9020827 Css 3compartmentss Human 95% 29.12 mg/L 2.371 mg/L 12.2817376634332 -DTXSID9020875 Css 3compartmentss Human 95% 9.631 mg/L 5.928 mg/L 1.62466261808367 -DTXSID9020902 Css 3compartmentss Human 95% 0.6933 mg/L 0.5147 mg/L 1.34699825140859 -DTXSID9020956 Css 3compartmentss Human 95% 14.03 mg/L 8.324 mg/L 1.68548774627583 -DTXSID9020958 Css 3compartmentss Human 95% 1.21 mg/L 0.8155 mg/L 1.48375229920294 -DTXSID9021053 Css 3compartmentss Human 95% 0.07681 mg/L 0.05105 mg/L 1.50460333006856 -DTXSID9021059 Css 3compartmentss Human 95% 4.626 mg/L 3.129 mg/L 1.4784276126558 -DTXSID9021130 Css 3compartmentss Human 95% 1.748 mg/L 1.636 mg/L 1.06845965770171 -DTXSID9021132 Css 3compartmentss Human 95% 3.726 mg/L 2.19 mg/L 1.7013698630137 -DTXSID9021134 Css 3compartmentss Human 95% 3.002 mg/L 2.068 mg/L 1.45164410058027 -DTXSID9021136 Css 3compartmentss Human 95% 239.4 mg/L 131.7 mg/L 1.81776765375854 -DTXSID9021138 Css 3compartmentss Human 95% 0.9068 mg/L 0.5816 mg/L 1.55914718019257 -DTXSID9021182 Css 3compartmentss Human 95% 0.8518 mg/L 0.5384 mg/L 1.58209509658247 -DTXSID9021184 Css 3compartmentss Human 95% 1.425 mg/L 1.103 mg/L 1.29193109700816 -DTXSID9021188 Css 3compartmentss Human 95% 8.288 mg/L 4.928 mg/L 1.68181818181818 -DTXSID9021215 Css 3compartmentss Human 95% 3.001 mg/L 1.788 mg/L 1.67841163310962 -DTXSID9021217 Css 3compartmentss Human 95% 9.8 mg/L 6.122 mg/L 1.60078405749755 -DTXSID9021219 Css 3compartmentss Human 95% 13.58 mg/L 7.867 mg/L 1.72619804245583 -DTXSID9021267 Css 3compartmentss Human 95% 0.184 mg/L 0.1282 mg/L 1.43525741029641 -DTXSID9021340 Css 3compartmentss Human 95% 4.042 mg/L 1.74 mg/L 2.32298850574713 -DTXSID9021342 Css 3compartmentss Human 95% 46.75 mg/L 2.195 mg/L 21.2984054669704 -DTXSID9021344 Css 3compartmentss Human 95% 1.518 mg/L 0.8423 mg/L 1.80220823934465 -DTXSID9021346 Css 3compartmentss Human 95% 0.9309 mg/L 0.5929 mg/L 1.57007927137797 -DTXSID9021348 Css 3compartmentss Human 95% 4.717 mg/L 3.381 mg/L 1.39514936409346 -DTXSID9021392 Css 3compartmentss Human 95% 2.034 mg/L 1.495 mg/L 1.36053511705686 -DTXSID9021396 Css 3compartmentss Human 95% 5.548 mg/L 3.436 mg/L 1.61466821885914 -DTXSID9021398 Css 3compartmentss Human 95% 3.372 mg/L 2.532 mg/L 1.33175355450237 -DTXSID9021425 Css 3compartmentss Human 95% 0.4148 mg/L 0.2776 mg/L 1.49423631123919 -DTXSID9021427 Css 3compartmentss Human 95% 5.312 mg/L 3.448 mg/L 1.54060324825986 -DTXSID9021477 Css 3compartmentss Human 95% 11530 mg/L 9647 mg/L 1.19519021457448 -DTXSID9021479 Css 3compartmentss Human 95% 4.112 mg/L 2.23 mg/L 1.84394618834081 -DTXSID9021554 Css 3compartmentss Human 95% 23.15 mg/L 12.82 mg/L 1.80577223088924 -DTXSID9021633 Css 3compartmentss Human 95% 8.495 mg/L 5.329 mg/L 1.59410771251642 -DTXSID9021637 Css 3compartmentss Human 95% 7.812 mg/L 4.946 mg/L 1.57945814799838 -DTXSID9021683 Css 3compartmentss Human 95% 42.39 mg/L 26.07 mg/L 1.62600690448792 -DTXSID9021685 Css 3compartmentss Human 95% 7.653 mg/L 5.796 mg/L 1.3203933747412 -DTXSID9021716 Css 3compartmentss Human 95% 1150 mg/L 747.6 mg/L 1.5382557517389 -DTXSID9021718 Css 3compartmentss Human 95% 0.04151 mg/L 0.02758 mg/L 1.50507614213198 -DTXSID9021762 Css 3compartmentss Human 95% 5.66 mg/L 3.614 mg/L 1.5661317100166 -DTXSID9021764 Css 3compartmentss Human 95% 4.772 mg/L 3.174 mg/L 1.50346565847511 -DTXSID9021841 Css 3compartmentss Human 95% 0.4211 mg/L 0.2426 mg/L 1.73577906018137 -DTXSID9021843 Css 3compartmentss Human 95% 1.631 mg/L 1.084 mg/L 1.50461254612546 -DTXSID9021897 Css 3compartmentss Human 95% 1.884 mg/L 1.362 mg/L 1.38325991189427 -DTXSID9021899 Css 3compartmentss Human 95% 1.713 mg/L 1.159 mg/L 1.47799827437446 -DTXSID9021922 Css 3compartmentss Human 95% 3.193 mg/L 2.105 mg/L 1.51686460807601 -DTXSID9021924 Css 3compartmentss Human 95% 1.233 mg/L 0.5508 mg/L 2.23856209150327 -DTXSID9021928 Css 3compartmentss Human 95% 0.08988 mg/L 0.05889 mg/L 1.52623535404992 -DTXSID9021976 Css 3compartmentss Human 95% 10.5 mg/L 6.574 mg/L 1.59720109522361 -DTXSID9022027 Css 3compartmentss Human 95% 0.6863 mg/L 0.4902 mg/L 1.4000407996736 -DTXSID9022100 Css 3compartmentss Human 95% 1.241 mg/L 1.059 mg/L 1.17186024551464 -DTXSID9022310 Css 3compartmentss Human 95% 4.41 mg/L 2.056 mg/L 2.14494163424125 -DTXSID9022312 Css 3compartmentss Human 95% 24.44 mg/L 0.4419 mg/L 55.30663045938 -DTXSID9022360 Css 3compartmentss Human 95% 3.527 mg/L 0.6498 mg/L 5.42782394582949 -DTXSID9022364 Css 3compartmentss Human 95% 1.948 mg/L 0.7556 mg/L 2.5780836421387 -DTXSID9022366 Css 3compartmentss Human 95% 57.05 mg/L 39.75 mg/L 1.43522012578616 -DTXSID9022445 Css 3compartmentss Human 95% 2.812 mg/L 1.93 mg/L 1.45699481865285 -DTXSID9022522 Css 3compartmentss Human 95% 16.11 mg/L 3.877 mg/L 4.15527469693062 -DTXSID9022524 Css 3compartmentss Human 95% 0.6062 mg/L 0.3608 mg/L 1.68015521064302 -DTXSID9022526 Css 3compartmentss Human 95% 0.8212 mg/L 0.3021 mg/L 2.71830519695465 -DTXSID9022528 Css 3compartmentss Human 95% 0.7934 mg/L 0.4867 mg/L 1.63016231764948 -DTXSID9022570 Css 3compartmentss Human 95% 54.24 mg/L 32.24 mg/L 1.68238213399504 -DTXSID9022574 Css 3compartmentss Human 95% 28.43 mg/L 0.05336 mg/L 532.796101949025 -DTXSID9022576 Css 3compartmentss Human 95% 2.905 mg/L 1.623 mg/L 1.78989525569932 -DTXSID9022578 Css 3compartmentss Human 95% 58.71 mg/L 34.93 mg/L 1.68079015173204 -DTXSID9022601 Css 3compartmentss Human 95% 218.9 mg/L 125.3 mg/L 1.74700718276137 -DTXSID9022603 Css 3compartmentss Human 95% 1.411 mg/L 0.9591 mg/L 1.47117088937546 -DTXSID9022607 Css 3compartmentss Human 95% 9.262 mg/L 6.11 mg/L 1.51587561374795 -DTXSID9022609 Css 3compartmentss Human 95% 106.1 mg/L 177 mg/L 0.599435028248588 -DTXSID9022655 Css 3compartmentss Human 95% 55.29 mg/L 38.64 mg/L 1.43090062111801 -DTXSID9022657 Css 3compartmentss Human 95% 0.6338 mg/L 0.3598 mg/L 1.7615341856587 -DTXSID9022659 Css 3compartmentss Human 95% 2.384 mg/L 0.5688 mg/L 4.19127988748242 -DTXSID9022730 Css 3compartmentss Human 95% 5.235 mg/L 3.527 mg/L 1.48426424723561 -DTXSID9022732 Css 3compartmentss Human 95% 6.039 mg/L 3.71 mg/L 1.6277628032345 -DTXSID9022734 Css 3compartmentss Human 95% 4.987 mg/L 2.173 mg/L 2.29498389323516 -DTXSID9022736 Css 3compartmentss Human 95% 0.3533 mg/L 0.2155 mg/L 1.63944315545244 -DTXSID9022738 Css 3compartmentss Human 95% 5.579 mg/L 3.442 mg/L 1.62085996513655 -DTXSID9022780 Css 3compartmentss Human 95% 1.736 mg/L 1.159 mg/L 1.49784296807593 -DTXSID9022782 Css 3compartmentss Human 95% 0.7813 mg/L 0.2968 mg/L 2.63241239892183 -DTXSID9022786 Css 3compartmentss Human 95% 67.4 mg/L 16.76 mg/L 4.02147971360382 -DTXSID9022813 Css 3compartmentss Human 95% 2.873 mg/L 1.536 mg/L 1.87044270833333 -DTXSID9022815 Css 3compartmentss Human 95% 0.4315 mg/L 0.1837 mg/L 2.34893848666304 -DTXSID9022817 Css 3compartmentss Human 95% 437.9 mg/L 241.3 mg/L 1.81475341898052 -DTXSID9022861 Css 3compartmentss Human 95% 3.608 mg/L 2.375 mg/L 1.51915789473684 -DTXSID9022940 Css 3compartmentss Human 95% 1.239 mg/L 1.22 mg/L 1.0155737704918 -DTXSID9022944 Css 3compartmentss Human 95% 1.482 mg/L 4.838e-05 mg/L 30632.4927656056 -DTXSID9022946 Css 3compartmentss Human 95% 50.83 mg/L 32.49 mg/L 1.56448137888581 -DTXSID9022994 Css 3compartmentss Human 95% 0.2914 mg/L 0.2679 mg/L 1.08771929824561 -DTXSID9022998 Css 3compartmentss Human 95% 5.497 mg/L 0.0003724 mg/L 14761.0096670247 -DTXSID9023041 Css 3compartmentss Human 95% 0.4704 mg/L 0.3032 mg/L 1.55145118733509 -DTXSID9023043 Css 3compartmentss Human 95% 59.34 mg/L 32.35 mg/L 1.83431221020093 -DTXSID9023045 Css 3compartmentss Human 95% 28.26 mg/L 14.35 mg/L 1.96933797909408 -DTXSID9023049 Css 3compartmentss Human 95% 6.777 mg/L 3.503 mg/L 1.93462746217528 -DTXSID9023095 Css 3compartmentss Human 95% 44.87 mg/L 24.63 mg/L 1.82176207876573 -DTXSID9023097 Css 3compartmentss Human 95% 53.16 mg/L 31.57 mg/L 1.68387709851124 -DTXSID9023122 Css 3compartmentss Human 95% 8.416 mg/L 5.547 mg/L 1.51721651343068 -DTXSID9023128 Css 3compartmentss Human 95% 2.942 mg/L 1.434 mg/L 2.05160390516039 -DTXSID9023170 Css 3compartmentss Human 95% 0.4246 mg/L 0.2887 mg/L 1.47073086248701 -DTXSID9023174 Css 3compartmentss Human 95% 0.9907 mg/L 0.3677 mg/L 2.69431601849334 -DTXSID9023176 Css 3compartmentss Human 95% 5.647 mg/L 3.307 mg/L 1.70758996068945 -DTXSID9023201 Css 3compartmentss Human 95% 32.38 mg/L 16.27 mg/L 1.99016594960049 -DTXSID9023205 Css 3compartmentss Human 95% 7.69 mg/L 6.08 mg/L 1.26480263157895 -DTXSID9023209 Css 3compartmentss Human 95% 6.292 mg/L 3.987 mg/L 1.57812891898671 -DTXSID9023255 Css 3compartmentss Human 95% 0.1184 mg/L 0.07307 mg/L 1.62036403448748 -DTXSID9023334 Css 3compartmentss Human 95% 39.97 mg/L 1.02e-07 mg/L 391862745.098039 -DTXSID9023336 Css 3compartmentss Human 95% 0.3083 mg/L 0.1959 mg/L 1.57376212353241 -DTXSID9023380 Css 3compartmentss Human 95% 61.98 mg/L 37.23 mg/L 1.66478646253022 -DTXSID9023384 Css 3compartmentss Human 95% 21.63 mg/L 17.62 mg/L 1.22758229284903 -DTXSID9023386 Css 3compartmentss Human 95% 7 mg/L 3.725 mg/L 1.87919463087248 -DTXSID9023388 Css 3compartmentss Human 95% 3.111 mg/L 2.137 mg/L 1.45577912962096 -DTXSID9023411 Css 3compartmentss Human 95% 7.476 mg/L 0.2672 mg/L 27.9790419161677 -DTXSID9023413 Css 3compartmentss Human 95% 0.07055 mg/L 0.03986 mg/L 1.76994480682388 -DTXSID9023415 Css 3compartmentss Human 95% 1614 mg/L 3682 mg/L 0.438348723519826 -DTXSID9023419 Css 3compartmentss Human 95% 5.144 mg/L 3.772 mg/L 1.36373276776246 -DTXSID9023463 Css 3compartmentss Human 95% 5.56 mg/L 3.261 mg/L 1.704998466728 -DTXSID9023540 Css 3compartmentss Human 95% 0.01147 mg/L 0.007162 mg/L 1.60150795867076 -DTXSID9023542 Css 3compartmentss Human 95% 0.7764 mg/L 0.5525 mg/L 1.40524886877828 -DTXSID9023546 Css 3compartmentss Human 95% 0.5046 mg/L 0.3511 mg/L 1.43719737966391 -DTXSID9023548 Css 3compartmentss Human 95% 0.431 mg/L 0.2559 mg/L 1.684251660805 -DTXSID9023590 Css 3compartmentss Human 95% 0.4711 mg/L 0.2936 mg/L 1.60456403269755 -DTXSID9023621 Css 3compartmentss Human 95% 1094 mg/L 641 mg/L 1.70670826833073 -DTXSID9023623 Css 3compartmentss Human 95% 10.52 mg/L 5.725 mg/L 1.83755458515284 -DTXSID9023629 Css 3compartmentss Human 95% 3.923 mg/L 1.765 mg/L 2.22266288951841 -DTXSID9023673 Css 3compartmentss Human 95% 0.9996 mg/L 0.6694 mg/L 1.49327756199582 -DTXSID9023677 Css 3compartmentss Human 95% 8.911 mg/L 4.335 mg/L 2.05559400230681 -DTXSID9023679 Css 3compartmentss Human 95% 0.2507 mg/L 0.1854 mg/L 1.35221143473571 -DTXSID9023702 Css 3compartmentss Human 95% 0.0491 mg/L 0.03778 mg/L 1.29962943356273 -DTXSID9023706 Css 3compartmentss Human 95% 29.13 mg/L 16.6 mg/L 1.75481927710843 -DTXSID9023752 Css 3compartmentss Human 95% 18.07 mg/L 10.12 mg/L 1.78557312252964 -DTXSID9023756 Css 3compartmentss Human 95% 2.079 mg/L 0.2999 mg/L 6.93231077025675 -DTXSID9023833 Css 3compartmentss Human 95% 8.09 mg/L 4.97 mg/L 1.62776659959759 -DTXSID9023835 Css 3compartmentss Human 95% 0.1029 mg/L 0.008697 mg/L 11.8316660917558 -DTXSID9023837 Css 3compartmentss Human 95% 6.757 mg/L 4.687 mg/L 1.44164710902496 -DTXSID9023881 Css 3compartmentss Human 95% 161.3 mg/L 135.8 mg/L 1.18777614138439 -DTXSID9023883 Css 3compartmentss Human 95% 28.11 mg/L 0.01341 mg/L 2096.19686800895 -DTXSID9023889 Css 3compartmentss Human 95% 9.05 mg/L 4.202 mg/L 2.15373631603998 -DTXSID9023914 Css 3compartmentss Human 95% 5.884 mg/L 3.618 mg/L 1.62631288004422 -DTXSID9024063 Css 3compartmentss Human 95% 0.7956 mg/L 0.6921 mg/L 1.14954486345904 -DTXSID9024065 Css 3compartmentss Human 95% 7.164 mg/L 4.814 mg/L 1.48815953469049 -DTXSID9024194 Css 3compartmentss Human 95% 46.73 mg/L 25.94 mg/L 1.80146491904395 -DTXSID9024300 Css 3compartmentss Human 95% 7.614 mg/L 4.76 mg/L 1.59957983193277 -DTXSID9024304 Css 3compartmentss Human 95% 7.928 mg/L 4.625 mg/L 1.71416216216216 -DTXSID9024431 Css 3compartmentss Human 95% 1.458 mg/L 1.079 mg/L 1.35125115848007 -DTXSID9024481 Css 3compartmentss Human 95% 1.37 mg/L 0.8162 mg/L 1.67851016907621 -DTXSID9024483 Css 3compartmentss Human 95% 1.67 mg/L 0.9217 mg/L 1.81186937181295 -DTXSID9024485 Css 3compartmentss Human 95% 0.3676 mg/L 0.2349 mg/L 1.56492124308216 -DTXSID9024487 Css 3compartmentss Human 95% 2.467 mg/L 1.614 mg/L 1.52850061957869 -DTXSID9024489 Css 3compartmentss Human 95% 0.2331 mg/L 0.178 mg/L 1.30955056179775 -DTXSID9024512 Css 3compartmentss Human 95% 1.017 mg/L 0.674 mg/L 1.50890207715134 -DTXSID9024568 Css 3compartmentss Human 95% 5.767 mg/L 3.525 mg/L 1.63602836879433 -DTXSID9024641 Css 3compartmentss Human 95% 6.33 mg/L 7.087 mg/L 0.893184704388317 -DTXSID9024699 Css 3compartmentss Human 95% 0.1463 mg/L 0.09836 mg/L 1.48739324928833 -DTXSID9024726 Css 3compartmentss Human 95% 5.652 mg/L 3.603 mg/L 1.56869275603664 -DTXSID9024770 Css 3compartmentss Human 95% 48.93 mg/L 30.15 mg/L 1.6228855721393 -DTXSID9024772 Css 3compartmentss Human 95% 85.06 mg/L 50.01 mg/L 1.70085982803439 -DTXSID9024809 Css 3compartmentss Human 95% 3.352 mg/L 3.362 mg/L 0.997025580011898 -DTXSID9024853 Css 3compartmentss Human 95% 0.5672 mg/L 0.3921 mg/L 1.44656975261413 -DTXSID9024855 Css 3compartmentss Human 95% 0.4597 mg/L 0.2864 mg/L 1.60509776536313 -DTXSID9024930 Css 3compartmentss Human 95% 0.6861 mg/L 0.4481 mg/L 1.53113144387414 -DTXSID9024934 Css 3compartmentss Human 95% 7.495 mg/L 3.952 mg/L 1.89650809716599 -DTXSID9024980 Css 3compartmentss Human 95% 273.5 mg/L 157.3 mg/L 1.73871582962492 -DTXSID9024986 Css 3compartmentss Human 95% 65.64 mg/L 49.6 mg/L 1.32338709677419 -DTXSID9025035 Css 3compartmentss Human 95% 7.677 mg/L 4.106 mg/L 1.86970287384316 -DTXSID9025037 Css 3compartmentss Human 95% 2.426 mg/L 1.966 mg/L 1.23397761953204 -DTXSID9025085 Css 3compartmentss Human 95% 4.638 mg/L 3.184 mg/L 1.45665829145729 -DTXSID9025087 Css 3compartmentss Human 95% 1.632 mg/L 0.7243 mg/L 2.25320999585807 -DTXSID9025110 Css 3compartmentss Human 95% 17.14 mg/L 0.09633 mg/L 177.930032181044 -DTXSID9025114 Css 3compartmentss Human 95% 3.641 mg/L 0.9303 mg/L 3.91379125013437 -DTXSID9025164 Css 3compartmentss Human 95% 6.867 mg/L 4.703 mg/L 1.46013183074633 -DTXSID9025166 Css 3compartmentss Human 95% 2.827 mg/L 1.817 mg/L 1.5558613098514 -DTXSID9025245 Css 3compartmentss Human 95% 4858 mg/L 9739 mg/L 0.498819180614026 -DTXSID9025293 Css 3compartmentss Human 95% 6.717 mg/L 4.021 mg/L 1.67047998010445 -DTXSID9025299 Css 3compartmentss Human 95% 13.78 mg/L 0.0118 mg/L 1167.79661016949 -DTXSID9025326 Css 3compartmentss Human 95% 7876 mg/L 5.879 mg/L 1339.68361966321 -DTXSID9025328 Css 3compartmentss Human 95% 21.04 mg/L 3.804 mg/L 5.53101997896951 -DTXSID9025370 Css 3compartmentss Human 95% 119.4 mg/L 66.4 mg/L 1.79819277108434 -DTXSID9025401 Css 3compartmentss Human 95% 13.08 mg/L 10.37 mg/L 1.26133076181292 -DTXSID9025409 Css 3compartmentss Human 95% 6.053 mg/L 3.243 mg/L 1.86648165279063 -DTXSID9025455 Css 3compartmentss Human 95% 5.999 mg/L 4.407 mg/L 1.36124347628772 -DTXSID9025536 Css 3compartmentss Human 95% 5.742 mg/L 3.985 mg/L 1.44090338770389 -DTXSID9025538 Css 3compartmentss Human 95% 3.892 mg/L 2.34 mg/L 1.66324786324786 -DTXSID9025588 Css 3compartmentss Human 95% 6.648 mg/L 3.978 mg/L 1.67119155354449 -DTXSID9025617 Css 3compartmentss Human 95% 2.349 mg/L 1.502 mg/L 1.56391478029294 -DTXSID9025665 Css 3compartmentss Human 95% 5.078 mg/L 3.057 mg/L 1.66110565914295 -DTXSID9025740 Css 3compartmentss Human 95% 3.056 mg/L 1.895 mg/L 1.61266490765171 -DTXSID9025742 Css 3compartmentss Human 95% 10.74 mg/L 6.934 mg/L 1.5488895298529 -DTXSID9025744 Css 3compartmentss Human 95% 2.319 mg/L 2.107 mg/L 1.10061699098244 -DTXSID9025746 Css 3compartmentss Human 95% 42.72 mg/L 31.56 mg/L 1.35361216730038 -DTXSID9025825 Css 3compartmentss Human 95% 0.08751 mg/L 0.03865 mg/L 2.26416558861578 -DTXSID9025873 Css 3compartmentss Human 95% 10.86 mg/L 6.463 mg/L 1.68033421011914 -DTXSID9025879 Css 3compartmentss Human 95% 51.27 mg/L 30.29 mg/L 1.69263783426874 -DTXSID9026051 Css 3compartmentss Human 95% 13.43 mg/L 15.32 mg/L 0.876631853785901 -DTXSID9026053 Css 3compartmentss Human 95% 0.2154 mg/L 0.1501 mg/L 1.43504330446369 -DTXSID9026059 Css 3compartmentss Human 95% 5.202 mg/L 3.391 mg/L 1.53406074904158 -DTXSID9026132 Css 3compartmentss Human 95% 0.01054 mg/L 0.007973 mg/L 1.32196162046908 -DTXSID9026219 Css 3compartmentss Human 95% 454.9 mg/L 9724 mg/L 0.0467811600164541 -DTXSID9026261 Css 3compartmentss Human 95% 74.12 mg/L 22.33 mg/L 3.31930138826691 -DTXSID9026265 Css 3compartmentss Human 95% 0.1415 mg/L 0 mg/L Inf -DTXSID9026267 Css 3compartmentss Human 95% 0.1183 mg/L 6.7e-08 mg/L 1765671.64179104 -DTXSID9026342 Css 3compartmentss Human 95% 1.164 mg/L 0.7517 mg/L 1.5484900891313 -DTXSID9026558 Css 3compartmentss Human 95% 0.9261 mg/L 0.5656 mg/L 1.63737623762376 -DTXSID9026631 Css 3compartmentss Human 95% 1.137 mg/L 0.8547 mg/L 1.33029133029133 -DTXSID9026633 Css 3compartmentss Human 95% 1.928 mg/L 1.272 mg/L 1.51572327044025 -DTXSID9026689 Css 3compartmentss Human 95% 6.282 mg/L 4.466 mg/L 1.40662785490372 -DTXSID9026710 Css 3compartmentss Human 95% 0.325 mg/L 0.2752 mg/L 1.18095930232558 -DTXSID9026712 Css 3compartmentss Human 95% 6.28 mg/L 4.845 mg/L 1.29618163054696 -DTXSID9026714 Css 3compartmentss Human 95% 7.257 mg/L 5.977 mg/L 1.21415425798896 -DTXSID9026716 Css 3compartmentss Human 95% 5.441 mg/L 3.535 mg/L 1.53917963224894 -DTXSID9026718 Css 3compartmentss Human 95% 8.04 mg/L 4.909 mg/L 1.63780810755755 -DTXSID9026841 Css 3compartmentss Human 95% 16.26 mg/L 0.007465 mg/L 2178.16476892163 -DTXSID9026849 Css 3compartmentss Human 95% 4.909 mg/L 3.257 mg/L 1.5072152287381 -DTXSID9026899 Css 3compartmentss Human 95% 1.542 mg/L 0.971 mg/L 1.58805355303811 -DTXSID9026922 Css 3compartmentss Human 95% 3.173 mg/L 3.34 mg/L 0.95 -DTXSID9026924 Css 3compartmentss Human 95% 0.1965 mg/L 0.000283 mg/L 694.34628975265 -DTXSID9026926 Css 3compartmentss Human 95% 9.767 mg/L 0.001247 mg/L 7832.39775461107 -DTXSID9026974 Css 3compartmentss Human 95% 7.082 mg/L 0.08342 mg/L 84.8957084631983 -DTXSID9027021 Css 3compartmentss Human 95% 8.029 mg/L 5.11 mg/L 1.57123287671233 -DTXSID9027104 Css 3compartmentss Human 95% 0.6957 mg/L 1e-09 mg/L 695700000 -DTXSID9027158 Css 3compartmentss Human 95% 1.38 mg/L 0.8929 mg/L 1.54552581476089 -DTXSID9027233 Css 3compartmentss Human 95% 7.396 mg/L 4.801 mg/L 1.54051239325141 -DTXSID9027239 Css 3compartmentss Human 95% 34.94 mg/L 20.24 mg/L 1.72628458498024 -DTXSID9027281 Css 3compartmentss Human 95% 34.29 mg/L 19.04 mg/L 1.80094537815126 -DTXSID9027312 Css 3compartmentss Human 95% 0.2916 mg/L 0.1929 mg/L 1.51166407465008 -DTXSID9027314 Css 3compartmentss Human 95% 7.099 mg/L 4.533 mg/L 1.5660710346349 -DTXSID9027360 Css 3compartmentss Human 95% 8.057 mg/L 4.86 mg/L 1.65781893004115 -DTXSID9027368 Css 3compartmentss Human 95% 1.371 mg/L 0.7948 mg/L 1.72496225465526 -DTXSID9027441 Css 3compartmentss Human 95% 0.6192 mg/L 0.002305 mg/L 268.633405639913 -DTXSID9027443 Css 3compartmentss Human 95% 3.148 mg/L 1.945 mg/L 1.61850899742931 -DTXSID9027520 Css 3compartmentss Human 95% 0.1306 mg/L 0.1081 mg/L 1.20814061054579 -DTXSID9027522 Css 3compartmentss Human 95% 27.57 mg/L 9.067 mg/L 3.04069703319731 -DTXSID9027528 Css 3compartmentss Human 95% 0.1091 mg/L 0.1114 mg/L 0.97935368043088 -DTXSID9027570 Css 3compartmentss Human 95% 4.978 mg/L 3.48 mg/L 1.43045977011494 -DTXSID9027603 Css 3compartmentss Human 95% 1.271 mg/L 0.7747 mg/L 1.64063508454886 -DTXSID9027738 Css 3compartmentss Human 95% 4309 mg/L 0.09665 mg/L 44583.5488877393 -DTXSID9027863 Css 3compartmentss Human 95% 5.7 mg/L 3.684 mg/L 1.54723127035831 -DTXSID9027948 Css 3compartmentss Human 95% 1077 mg/L 9739 mg/L 0.110586302495123 -DTXSID9029017 Css 3compartmentss Human 95% 1.15 mg/L 5.17e-07 mg/L 2224371.37330754 -DTXSID9029061 Css 3compartmentss Human 95% 0.4472 mg/L 0.4229 mg/L 1.05746039252778 -DTXSID9029146 Css 3compartmentss Human 95% 5.508 mg/L 3.778 mg/L 1.4579142403388 -DTXSID9029221 Css 3compartmentss Human 95% 1.708 mg/L 1.187 mg/L 1.43892165122157 -DTXSID9029225 Css 3compartmentss Human 95% 5.274 mg/L 2.503 mg/L 2.10707151418298 -DTXSID9029275 Css 3compartmentss Human 95% 4.662 mg/L 3.167 mg/L 1.47205557309757 -DTXSID9029279 Css 3compartmentss Human 95% 9.51 mg/L 5.881 mg/L 1.6170719265431 -DTXSID9029300 Css 3compartmentss Human 95% 44.91 mg/L 38.32 mg/L 1.17197286012526 -DTXSID9029302 Css 3compartmentss Human 95% 6.618 mg/L 2.716 mg/L 2.43667157584683 -DTXSID9029304 Css 3compartmentss Human 95% 10130 mg/L 9739 mg/L 1.04014785912311 -DTXSID9029649 Css 3compartmentss Human 95% 0.7146 mg/L 0.5838 mg/L 1.224049331963 -DTXSID9029691 Css 3compartmentss Human 95% 6.84 mg/L 4.216 mg/L 1.62239089184061 -DTXSID9029695 Css 3compartmentss Human 95% 12.16 mg/L 7.424 mg/L 1.63793103448276 -DTXSID9030707 Css 3compartmentss Human 95% 10.41 mg/L 7.806 mg/L 1.33358954650269 -DTXSID9031800 Css 3compartmentss Human 95% 4.257 mg/L 2.255 mg/L 1.88780487804878 -DTXSID9032113 Css 3compartmentss Human 95% 16.96 mg/L 9.705 mg/L 1.74755280783101 -DTXSID9032327 Css 3compartmentss Human 95% 0.7933 mg/L 0.4641 mg/L 1.70932988580047 -DTXSID9032329 Css 3compartmentss Human 95% 2.694 mg/L 0.2896 mg/L 9.3024861878453 -DTXSID9032375 Css 3compartmentss Human 95% 205.7 mg/L 119.5 mg/L 1.72133891213389 -DTXSID9032379 Css 3compartmentss Human 95% 30.38 mg/L 1.757 mg/L 17.2908366533865 -DTXSID9032406 Css 3compartmentss Human 95% 7.005 mg/L 4.051 mg/L 1.72920266600839 -DTXSID9032531 Css 3compartmentss Human 95% 10.82 mg/L 6.196 mg/L 1.74628792769529 -DTXSID9032533 Css 3compartmentss Human 95% 46.25 mg/L 2.219 mg/L 20.8427219468229 -DTXSID9032535 Css 3compartmentss Human 95% 3.723 mg/L 2.286 mg/L 1.62860892388451 -DTXSID9032537 Css 3compartmentss Human 95% 51.61 mg/L 152.8 mg/L 0.337761780104712 -DTXSID9032581 Css 3compartmentss Human 95% 707.2 mg/L 566.8 mg/L 1.24770642201835 -DTXSID9032589 Css 3compartmentss Human 95% 168.1 mg/L 16.4 mg/L 10.25 -DTXSID9032610 Css 3compartmentss Human 95% 0.7466 mg/L 5.12e-07 mg/L 1458203.125 -DTXSID9032614 Css 3compartmentss Human 95% 11.18 mg/L 0.9618 mg/L 11.6240382615928 -DTXSID9032878 Css 3compartmentss Human 95% 2.949 mg/L 2.183 mg/L 1.3508932661475 -DTXSID9033008 Css 3compartmentss Human 95% 21.93 mg/L 12.38 mg/L 1.77140549273021 -DTXSID9033058 Css 3compartmentss Human 95% 2.734 mg/L 1.672 mg/L 1.63516746411483 -DTXSID9033187 Css 3compartmentss Human 95% 1.106 mg/L 0.02201 mg/L 50.2498864152658 -DTXSID9033264 Css 3compartmentss Human 95% 8.521 mg/L 6.239 mg/L 1.36576374418977 -DTXSID9033896 Css 3compartmentss Human 95% 44.57 mg/L 35.07 mg/L 1.27088679783291 -DTXSID9033923 Css 3compartmentss Human 95% 11.89 mg/L 6.048 mg/L 1.96593915343915 -DTXSID9033979 Css 3compartmentss Human 95% 45.32 mg/L 26.69 mg/L 1.69801423754215 -DTXSID9034232 Css 3compartmentss Human 95% 306.5 mg/L 176.5 mg/L 1.73654390934844 -DTXSID9034282 Css 3compartmentss Human 95% 13.11 mg/L 7.34 mg/L 1.78610354223433 -DTXSID9034286 Css 3compartmentss Human 95% 1.631 mg/L 0.7692 mg/L 2.12038481539262 -DTXSID9034317 Css 3compartmentss Human 95% 0.07535 mg/L 0.04503 mg/L 1.67332889184988 -DTXSID9034361 Css 3compartmentss Human 95% 358.5 mg/L 234.9 mg/L 1.52618135376756 -DTXSID9034365 Css 3compartmentss Human 95% 13.02 mg/L 6.994 mg/L 1.86159565341721 -DTXSID9034490 Css 3compartmentss Human 95% 8.118 mg/L 5.324 mg/L 1.52479338842975 -DTXSID9034492 Css 3compartmentss Human 95% 5.089 mg/L 2.888 mg/L 1.76211911357341 -DTXSID9034573 Css 3compartmentss Human 95% 435.8 mg/L 249.1 mg/L 1.74949819349659 -DTXSID9034650 Css 3compartmentss Human 95% 718.4 mg/L 421.3 mg/L 1.70519819605981 -DTXSID9034816 Css 3compartmentss Human 95% 0.7865 mg/L 0.6319 mg/L 1.24465896502611 -DTXSID9034818 Css 3compartmentss Human 95% 0.01186 mg/L 0.00871 mg/L 1.36165327210103 -DTXSID9034864 Css 3compartmentss Human 95% 131.2 mg/L 74.74 mg/L 1.75541878512176 -DTXSID9034997 Css 3compartmentss Human 95% 1.084 mg/L 9.713e-06 mg/L 111603.006280243 -DTXSID9035175 Css 3compartmentss Human 95% 1.084 mg/L 0.7505 mg/L 1.44437041972019 -DTXSID9035204 Css 3compartmentss Human 95% 1.097 mg/L 6.83e-07 mg/L 1606149.34114202 -DTXSID9035620 Css 3compartmentss Human 95% 9.115 mg/L 7.611 mg/L 1.19760872421495 -DTXSID9035753 Css 3compartmentss Human 95% 0.5461 mg/L 0.4 mg/L 1.36525 -DTXSID9036226 Css 3compartmentss Human 95% 3.092 mg/L 1.831 mg/L 1.68869470234844 -DTXSID9036438 Css 3compartmentss Human 95% 9.433 mg/L 2.457 mg/L 3.83923483923484 -DTXSID9036515 Css 3compartmentss Human 95% 21.05 mg/L 5.037 mg/L 4.17907484613858 -DTXSID9036646 Css 3compartmentss Human 95% 8.247 mg/L 5.398 mg/L 1.52778806965543 -DTXSID9036690 Css 3compartmentss Human 95% 0.1395 mg/L 0.1354 mg/L 1.03028064992614 -DTXSID9036933 Css 3compartmentss Human 95% 6.827 mg/L 9739 mg/L 0.000700995995482082 -DTXSID9037038 Css 3compartmentss Human 95% 2.201 mg/L 1.353 mg/L 1.62675535846268 -DTXSID9037246 Css 3compartmentss Human 95% 4.946 mg/L 3.345 mg/L 1.47862481315396 -DTXSID9037248 Css 3compartmentss Human 95% 0.03841 mg/L 0.02602 mg/L 1.47617217524981 -DTXSID9037535 Css 3compartmentss Human 95% 0.1132 mg/L 0.07152 mg/L 1.582774049217 -DTXSID9037539 Css 3compartmentss Human 95% 11.55 mg/L 2.89 mg/L 3.99653979238754 -DTXSID9037612 Css 3compartmentss Human 95% 2.8 mg/L 1.222 mg/L 2.29132569558101 -DTXSID9037616 Css 3compartmentss Human 95% 3.925 mg/L 2.286 mg/L 1.7169728783902 -DTXSID9037741 Css 3compartmentss Human 95% 1.469 mg/L 0.6057 mg/L 2.42529304936437 -DTXSID9037745 Css 3compartmentss Human 95% 2.239 mg/L 0.4474 mg/L 5.00447027268663 -DTXSID9037749 Css 3compartmentss Human 95% 9.462 mg/L 2.453 mg/L 3.85731757032205 -DTXSID9038686 Css 3compartmentss Human 95% 34.8 mg/L 20.1 mg/L 1.73134328358209 -DTXSID9039238 Css 3compartmentss Human 95% 3.306 mg/L 2.95 mg/L 1.12067796610169 -DTXSID9040001 Css 3compartmentss Human 95% 5.797 mg/L 3.74 mg/L 1.55 -DTXSID9040130 Css 3compartmentss Human 95% 1.074 mg/L 0.6937 mg/L 1.5482196915093 -DTXSID9040134 Css 3compartmentss Human 95% 2.914 mg/L 2.908 mg/L 1.00206327372765 -DTXSID9040215 Css 3compartmentss Human 95% 1.903 mg/L 1.786 mg/L 1.06550951847704 -DTXSID9040265 Css 3compartmentss Human 95% 4.412 mg/L 0.9037 mg/L 4.8821511563572 -DTXSID9040269 Css 3compartmentss Human 95% 0.8941 mg/L 0.5077 mg/L 1.76107937758519 -DTXSID9040342 Css 3compartmentss Human 95% 5.573 mg/L 3.688 mg/L 1.51111713665944 -DTXSID9040502 Css 3compartmentss Human 95% 2.33 mg/L 0.3876 mg/L 6.01135190918473 -DTXSID9040554 Css 3compartmentss Human 95% 1.281 mg/L 0.8967 mg/L 1.42857142857143 -DTXSID9040635 Css 3compartmentss Human 95% 2.599 mg/L 1.605 mg/L 1.61931464174455 -DTXSID9040683 Css 3compartmentss Human 95% 3.112 mg/L 1.761 mg/L 1.7671777399205 -DTXSID9040685 Css 3compartmentss Human 95% 5.402 mg/L 3.477 mg/L 1.55363819384527 -DTXSID9040687 Css 3compartmentss Human 95% 39.21 mg/L 20.86 mg/L 1.87967401725791 -DTXSID9040712 Css 3compartmentss Human 95% 6.149 mg/L 0.006828 mg/L 900.556531927358 -DTXSID9040714 Css 3compartmentss Human 95% 4.772 mg/L 3.831 mg/L 1.2456277734273 -DTXSID9040716 Css 3compartmentss Human 95% 33.85 mg/L 40.81 mg/L 0.829453565302622 -DTXSID9040718 Css 3compartmentss Human 95% 0.06355 mg/L 0.03824 mg/L 1.66187238493724 -DTXSID9041021 Css 3compartmentss Human 95% 5.294 mg/L 3.391 mg/L 1.5611913889708 -DTXSID9041023 Css 3compartmentss Human 95% 8.791 mg/L 1.363 mg/L 6.44974321349963 -DTXSID9041104 Css 3compartmentss Human 95% 5.576 mg/L 3.628 mg/L 1.53693495038589 -DTXSID9041152 Css 3compartmentss Human 95% 2.434 mg/L 1.19 mg/L 2.0453781512605 -DTXSID9041233 Css 3compartmentss Human 95% 41.26 mg/L 24.52 mg/L 1.68270799347471 -DTXSID9041362 Css 3compartmentss Human 95% 4.772 mg/L 3.139 mg/L 1.5202293724116 -DTXSID9041366 Css 3compartmentss Human 95% 0.3508 mg/L 0.2279 mg/L 1.53927161035542 -DTXSID9041368 Css 3compartmentss Human 95% 5.481 mg/L 3.347 mg/L 1.63758589781894 -DTXSID9041441 Css 3compartmentss Human 95% 14.49 mg/L 8.356 mg/L 1.73408329344184 -DTXSID9041491 Css 3compartmentss Human 95% 1.11 mg/L 0.77 mg/L 1.44155844155844 -DTXSID9041520 Css 3compartmentss Human 95% 1.042 mg/L 0.6496 mg/L 1.60406403940887 -DTXSID9041524 Css 3compartmentss Human 95% 4.937 mg/L 3.101 mg/L 1.59206707513705 -DTXSID9041528 Css 3compartmentss Human 95% 1.205 mg/L 0.7658 mg/L 1.57351788978846 -DTXSID9041570 Css 3compartmentss Human 95% 5.681 mg/L 3.257 mg/L 1.74424316856002 -DTXSID9041607 Css 3compartmentss Human 95% 0.5851 mg/L 0.3519 mg/L 1.66268826371128 -DTXSID9041653 Css 3compartmentss Human 95% 0.5233 mg/L 0.2857 mg/L 1.8316415820791 -DTXSID9041659 Css 3compartmentss Human 95% 21.14 mg/L 12.67 mg/L 1.66850828729282 -DTXSID9041813 Css 3compartmentss Human 95% 2.133 mg/L 1.759 mg/L 1.21262080727686 -DTXSID9041815 Css 3compartmentss Human 95% 2.311 mg/L 2.222 mg/L 1.04005400540054 -DTXSID9041861 Css 3compartmentss Human 95% 5.986 mg/L 3.572 mg/L 1.67581187010078 -DTXSID9042124 Css 3compartmentss Human 95% 12.34 mg/L 7.519 mg/L 1.64117568825642 -DTXSID9042170 Css 3compartmentss Human 95% 0.5492 mg/L 0.4559 mg/L 1.20465014257513 -DTXSID9042203 Css 3compartmentss Human 95% 5.834 mg/L 3.801 mg/L 1.53485924756643 -DTXSID9042209 Css 3compartmentss Human 95% 0.08399 mg/L 9.087e-05 mg/L 924.287443600748 -DTXSID9042259 Css 3compartmentss Human 95% 11.74 mg/L 6.752 mg/L 1.73874407582938 -DTXSID9042336 Css 3compartmentss Human 95% 3.361 mg/L 2.294 mg/L 1.46512641673932 -DTXSID9042338 Css 3compartmentss Human 95% 0.3374 mg/L 0.2214 mg/L 1.52393857271906 -DTXSID9042382 Css 3compartmentss Human 95% 1.572 mg/L 0.4788 mg/L 3.28320802005013 -DTXSID9042415 Css 3compartmentss Human 95% 7.666 mg/L 4.611 mg/L 1.66254608544784 -DTXSID9042465 Css 3compartmentss Human 95% 6.899 mg/L 4.327 mg/L 1.59440721053848 -DTXSID9042592 Css 3compartmentss Human 95% 2.509 mg/L 1.309 mg/L 1.91673032849503 -DTXSID9042594 Css 3compartmentss Human 95% 6.545 mg/L 0.08752 mg/L 74.7829067641682 -DTXSID9043853 Css 3compartmentss Human 95% 1.441 mg/L 0.9238 mg/L 1.55986144187053 -DTXSID9043855 Css 3compartmentss Human 95% 25.8 mg/L 14.83 mg/L 1.73971679028995 -DTXSID9043938 Css 3compartmentss Human 95% 137 mg/L 81.68 mg/L 1.67727717923604 -DTXSID9043988 Css 3compartmentss Human 95% 0.7178 mg/L 0.07647 mg/L 9.38668758990454 -DTXSID9044112 Css 3compartmentss Human 95% 4.595 mg/L 2.447 mg/L 1.87780956272987 -DTXSID9044164 Css 3compartmentss Human 95% 2.307 mg/L 0.8279 mg/L 2.78656842613842 -DTXSID9044241 Css 3compartmentss Human 95% 8.763 mg/L 5.297 mg/L 1.65433264111761 -DTXSID9044247 Css 3compartmentss Human 95% 3.502 mg/L 2.4 mg/L 1.45916666666667 -DTXSID9044299 Css 3compartmentss Human 95% 8.526 mg/L 4.618 mg/L 1.84625378951927 -DTXSID9044320 Css 3compartmentss Human 95% 3.764 mg/L 2.505 mg/L 1.50259481037924 -DTXSID9044322 Css 3compartmentss Human 95% 0.1089 mg/L 0.00296 mg/L 36.7905405405405 -DTXSID9044328 Css 3compartmentss Human 95% 12.36 mg/L 7.681 mg/L 1.60916547324567 -DTXSID9044370 Css 3compartmentss Human 95% 4.034 mg/L 2.798 mg/L 1.44174410293066 -DTXSID9044372 Css 3compartmentss Human 95% 0.04128 mg/L 0.03548 mg/L 1.16347237880496 -DTXSID9044374 Css 3compartmentss Human 95% 1.169 mg/L 0.8705 mg/L 1.34290637564618 -DTXSID9044378 Css 3compartmentss Human 95% 23.79 mg/L 13.65 mg/L 1.74285714285714 -DTXSID9044401 Css 3compartmentss Human 95% 1.472 mg/L 1.063 mg/L 1.38476011288805 -DTXSID9044403 Css 3compartmentss Human 95% 0.4996 mg/L 0.3405 mg/L 1.46725403817915 -DTXSID9044405 Css 3compartmentss Human 95% 4.877 mg/L 3.425 mg/L 1.42394160583942 -DTXSID9044407 Css 3compartmentss Human 95% 0.9404 mg/L 0.9874 mg/L 0.952400243062589 -DTXSID9044451 Css 3compartmentss Human 95% 6.985 mg/L 4.264 mg/L 1.63813320825516 -DTXSID9044455 Css 3compartmentss Human 95% 26.28 mg/L 26.54 mg/L 0.990203466465712 -DTXSID9044459 Css 3compartmentss Human 95% 255.5 mg/L 75.18 mg/L 3.39851024208566 -DTXSID9044532 Css 3compartmentss Human 95% 7.415 mg/L 1.016 mg/L 7.29822834645669 -DTXSID9044534 Css 3compartmentss Human 95% 0.9592 mg/L 0.6411 mg/L 1.49617844330058 -DTXSID9044536 Css 3compartmentss Human 95% 46.52 mg/L 0.4021 mg/L 115.692613777667 -DTXSID9044538 Css 3compartmentss Human 95% 2649 mg/L 1530 mg/L 1.73137254901961 -DTXSID9044580 Css 3compartmentss Human 95% 0.2893 mg/L 0.1732 mg/L 1.6703233256351 -DTXSID9044582 Css 3compartmentss Human 95% 21.06 mg/L 3.078 mg/L 6.84210526315789 -DTXSID9044588 Css 3compartmentss Human 95% 7.103 mg/L 4.814 mg/L 1.47548815953469 -DTXSID9044611 Css 3compartmentss Human 95% 14.54 mg/L 8.917 mg/L 1.63059324885051 -DTXSID9044613 Css 3compartmentss Human 95% 26.5 mg/L 30.81 mg/L 0.86011035378124 -DTXSID9044615 Css 3compartmentss Human 95% 2.685 mg/L 1.832 mg/L 1.46561135371179 -DTXSID9044661 Css 3compartmentss Human 95% 27.55 mg/L 6.1 mg/L 4.51639344262295 -DTXSID9044663 Css 3compartmentss Human 95% 269.9 mg/L 156.1 mg/L 1.7290198590647 -DTXSID9044667 Css 3compartmentss Human 95% 0.04533 mg/L 0.02645 mg/L 1.71379962192817 -DTXSID9044740 Css 3compartmentss Human 95% 0.2404 mg/L 0.159 mg/L 1.51194968553459 -DTXSID9044742 Css 3compartmentss Human 95% 0.08508 mg/L 0.07043 mg/L 1.20800795115718 -DTXSID9044744 Css 3compartmentss Human 95% 1.426 mg/L 0.9976 mg/L 1.42943063352045 -DTXSID9044748 Css 3compartmentss Human 95% 3.162 mg/L 2.962 mg/L 1.06752194463201 -DTXSID9044790 Css 3compartmentss Human 95% 6.055 mg/L 3.039 mg/L 1.99243172096084 -DTXSID9044794 Css 3compartmentss Human 95% 4.016 mg/L 2.383 mg/L 1.68527066722619 -DTXSID9044796 Css 3compartmentss Human 95% 1.747 mg/L 3.704e-06 mg/L 471652.267818575 -DTXSID9044821 Css 3compartmentss Human 95% 3.708 mg/L 1.246 mg/L 2.97592295345104 -DTXSID9044823 Css 3compartmentss Human 95% 7.817 mg/L 4.835 mg/L 1.61675284384695 -DTXSID9044825 Css 3compartmentss Human 95% 1.278 mg/L 0.5857 mg/L 2.18200443913266 -DTXSID9044827 Css 3compartmentss Human 95% 0.07047 mg/L 0.0686 mg/L 1.02725947521866 -DTXSID9044829 Css 3compartmentss Human 95% 11.25 mg/L 1.272 mg/L 8.84433962264151 -DTXSID9044875 Css 3compartmentss Human 95% 4.056 mg/L 2.807 mg/L 1.44495903099394 -DTXSID9044877 Css 3compartmentss Human 95% 0.4227 mg/L 0.3016 mg/L 1.40152519893899 -DTXSID9044879 Css 3compartmentss Human 95% 7.655 mg/L 5.095 mg/L 1.50245338567223 -DTXSID9044900 Css 3compartmentss Human 95% 8.147 mg/L 5.666 mg/L 1.43787504412284 -DTXSID9044902 Css 3compartmentss Human 95% 26.06 mg/L 14.52 mg/L 1.79476584022039 -DTXSID9044904 Css 3compartmentss Human 95% 14.76 mg/L 8.888 mg/L 1.66066606660666 -DTXSID9044908 Css 3compartmentss Human 95% 7.209 mg/L 5.787 mg/L 1.2457231726283 -DTXSID9044950 Css 3compartmentss Human 95% 583.3 mg/L 322.1 mg/L 1.81092828314188 -DTXSID9044958 Css 3compartmentss Human 95% 7.03 mg/L 4.289 mg/L 1.63907670785731 -DTXSID9045003 Css 3compartmentss Human 95% 3.813 mg/L 5.757 mg/L 0.662324127149557 -DTXSID9045007 Css 3compartmentss Human 95% 27.81 mg/L 16.58 mg/L 1.6773220747889 -DTXSID9045132 Css 3compartmentss Human 95% 102.8 mg/L 85.01 mg/L 1.20926949770615 -DTXSID9045136 Css 3compartmentss Human 95% 6.581 mg/L 3.156 mg/L 2.08523447401774 -DTXSID9045138 Css 3compartmentss Human 95% 0.2825 mg/L 0.2107 mg/L 1.34076886568581 -DTXSID9045180 Css 3compartmentss Human 95% 5.301 mg/L 3.628 mg/L 1.46113561190739 -DTXSID9045182 Css 3compartmentss Human 95% 1.466 mg/L 0.9863 mg/L 1.48636317550441 -DTXSID9045184 Css 3compartmentss Human 95% 0.6598 mg/L 0.3065 mg/L 2.15269168026101 -DTXSID9045186 Css 3compartmentss Human 95% 7.579 mg/L 4.66 mg/L 1.62639484978541 -DTXSID9045188 Css 3compartmentss Human 95% 1.155 mg/L 0.7201 mg/L 1.60394389668102 -DTXSID9045215 Css 3compartmentss Human 95% 9.098 mg/L 5.669 mg/L 1.60486858352443 -DTXSID9045217 Css 3compartmentss Human 95% 16.69 mg/L 8.088 mg/L 2.0635509396637 -DTXSID9045265 Css 3compartmentss Human 95% 17.58 mg/L 9.617 mg/L 1.82801289383384 -DTXSID9045267 Css 3compartmentss Human 95% 2.172 mg/L 1.498 mg/L 1.44993324432577 -DTXSID9045342 Css 3compartmentss Human 95% 5.25 mg/L 2.158 mg/L 2.43280815569972 -DTXSID9045344 Css 3compartmentss Human 95% 6.989 mg/L 4.624 mg/L 1.51146193771626 -DTXSID9045346 Css 3compartmentss Human 95% 1.892 mg/L 1.145 mg/L 1.65240174672489 -DTXSID9045348 Css 3compartmentss Human 95% 14.31 mg/L 0.06512 mg/L 219.748157248157 -DTXSID9045390 Css 3compartmentss Human 95% 0.474 mg/L 0.329 mg/L 1.44072948328267 -DTXSID9045392 Css 3compartmentss Human 95% 0.1294 mg/L 0.08075 mg/L 1.60247678018576 -DTXSID9045394 Css 3compartmentss Human 95% 6.624 mg/L 3.931 mg/L 1.68506741287204 -DTXSID9045398 Css 3compartmentss Human 95% 0.2539 mg/L 0.1696 mg/L 1.49705188679245 -DTXSID9045425 Css 3compartmentss Human 95% 0.6765 mg/L 0.382 mg/L 1.77094240837696 -DTXSID9045429 Css 3compartmentss Human 95% 1.085 mg/L 0.7056 mg/L 1.53769841269841 -DTXSID9045479 Css 3compartmentss Human 95% 0.8937 mg/L 0.5608 mg/L 1.59361626248217 -DTXSID9045500 Css 3compartmentss Human 95% 2.09 mg/L 1.249 mg/L 1.67333867093675 -DTXSID9045502 Css 3compartmentss Human 95% 2.575 mg/L 1.68 mg/L 1.5327380952381 -DTXSID9045506 Css 3compartmentss Human 95% 22.27 mg/L 13.02 mg/L 1.71044546850998 -DTXSID9045508 Css 3compartmentss Human 95% 4.06 mg/L 2.011 mg/L 2.01889607160617 -DTXSID9045550 Css 3compartmentss Human 95% 9.031 mg/L 5.473 mg/L 1.6501004933309 -DTXSID9045552 Css 3compartmentss Human 95% 343.1 mg/L 206.1 mg/L 1.66472586123241 -DTXSID9045556 Css 3compartmentss Human 95% 1.317 mg/L 1.315 mg/L 1.00152091254753 -DTXSID9045558 Css 3compartmentss Human 95% 7.762 mg/L 4.38 mg/L 1.77214611872146 -DTXSID9045631 Css 3compartmentss Human 95% 13.33 mg/L 0.9089 mg/L 14.6660798767741 -DTXSID9045633 Css 3compartmentss Human 95% 1.594 mg/L 0.7931 mg/L 2.00983482536881 -DTXSID9045635 Css 3compartmentss Human 95% 5.978 mg/L 0.9096 mg/L 6.57211961301671 -DTXSID9045637 Css 3compartmentss Human 95% 7.557 mg/L 5.677 mg/L 1.33116082437907 -DTXSID9045639 Css 3compartmentss Human 95% 7.088 mg/L 3.977 mg/L 1.78224792557204 -DTXSID9045683 Css 3compartmentss Human 95% 0.4245 mg/L 0.2989 mg/L 1.42020742723319 -DTXSID9045685 Css 3compartmentss Human 95% 17.11 mg/L 10.1 mg/L 1.69405940594059 -DTXSID9045687 Css 3compartmentss Human 95% 24.84 mg/L 15.37 mg/L 1.61613532856213 -DTXSID9045689 Css 3compartmentss Human 95% 3.621 mg/L 0.7273 mg/L 4.97868829918878 -DTXSID9045710 Css 3compartmentss Human 95% 0.49 mg/L 0.3567 mg/L 1.37370339220634 -DTXSID9045762 Css 3compartmentss Human 95% 0.103 mg/L 0.01297 mg/L 7.9414032382421 -DTXSID9045764 Css 3compartmentss Human 95% 9.571 mg/L 5.347 mg/L 1.78997568730129 -DTXSID9045766 Css 3compartmentss Human 95% 7335 mg/L 8426 mg/L 0.870519819605981 -DTXSID9045768 Css 3compartmentss Human 95% 0.9059 mg/L 0.03477 mg/L 26.0540696002301 -DTXSID9045843 Css 3compartmentss Human 95% 0.1654 mg/L 0.1011 mg/L 1.63600395647873 -DTXSID9045845 Css 3compartmentss Human 95% 1.805 mg/L 1.141 mg/L 1.58194566170026 -DTXSID9045847 Css 3compartmentss Human 95% 1.869 mg/L 1.041 mg/L 1.79538904899135 -DTXSID9045849 Css 3compartmentss Human 95% 194.3 mg/L 111.2 mg/L 1.74730215827338 -DTXSID9045891 Css 3compartmentss Human 95% 4.749 mg/L 3.248 mg/L 1.46213054187192 -DTXSID9045895 Css 3compartmentss Human 95% 309 mg/L 159.7 mg/L 1.9348778960551 -DTXSID9045897 Css 3compartmentss Human 95% 6.144 mg/L 3.794 mg/L 1.61939905113337 -DTXSID9045899 Css 3compartmentss Human 95% 3.965 mg/L 2.54 mg/L 1.56102362204724 -DTXSID9045922 Css 3compartmentss Human 95% 58.33 mg/L 33.92 mg/L 1.71963443396226 -DTXSID9045924 Css 3compartmentss Human 95% 124.9 mg/L 62.38 mg/L 2.00224430907342 -DTXSID9045928 Css 3compartmentss Human 95% 32.6 mg/L 17.99 mg/L 1.81211784324625 -DTXSID9045976 Css 3compartmentss Human 95% 10.94 mg/L 6.416 mg/L 1.70511221945137 -DTXSID9045978 Css 3compartmentss Human 95% 0.08837 mg/L 4e-09 mg/L 22092500 -DTXSID9046023 Css 3compartmentss Human 95% 1.224 mg/L 0.7389 mg/L 1.65651644336175 -DTXSID9046029 Css 3compartmentss Human 95% 62.67 mg/L 20.05 mg/L 3.12568578553616 -DTXSID9046071 Css 3compartmentss Human 95% 5.289 mg/L 3.024 mg/L 1.74900793650794 -DTXSID9046073 Css 3compartmentss Human 95% 6.808 mg/L 3.956 mg/L 1.72093023255814 -DTXSID9046100 Css 3compartmentss Human 95% 0.9643 mg/L 0.6077 mg/L 1.58680269870002 -DTXSID9046102 Css 3compartmentss Human 95% 10.47 mg/L 6.426 mg/L 1.62931839402428 -DTXSID9046104 Css 3compartmentss Human 95% 625.8 mg/L 334 mg/L 1.87365269461078 -DTXSID9046106 Css 3compartmentss Human 95% 13.02 mg/L 7.787 mg/L 1.67201746500578 -DTXSID9046108 Css 3compartmentss Human 95% 1.822 mg/L 1.15 mg/L 1.58434782608696 -DTXSID9046150 Css 3compartmentss Human 95% 0.3909 mg/L 0.3072 mg/L 1.2724609375 -DTXSID9046152 Css 3compartmentss Human 95% 0.1984 mg/L 0.09749 mg/L 2.03508052107908 -DTXSID9046154 Css 3compartmentss Human 95% 4.432 mg/L 3.078 mg/L 1.43989603638726 -DTXSID9046156 Css 3compartmentss Human 95% 162.1 mg/L 77.72 mg/L 2.08569222851261 -DTXSID9046158 Css 3compartmentss Human 95% 480.5 mg/L 270.1 mg/L 1.77897075157349 -DTXSID9046231 Css 3compartmentss Human 95% 11.13 mg/L 6.12 mg/L 1.81862745098039 -DTXSID9046233 Css 3compartmentss Human 95% 0.3709 mg/L 0.22 mg/L 1.68590909090909 -DTXSID9046235 Css 3compartmentss Human 95% 154.7 mg/L 78.31 mg/L 1.97548205848551 -DTXSID9046237 Css 3compartmentss Human 95% 5.958 mg/L 1.586 mg/L 3.75662042875158 -DTXSID9046239 Css 3compartmentss Human 95% 5.226 mg/L 3.287 mg/L 1.58989960450259 -DTXSID9046281 Css 3compartmentss Human 95% 46.05 mg/L 32.94 mg/L 1.39799635701275 -DTXSID9046283 Css 3compartmentss Human 95% 2.831 mg/L 1.485 mg/L 1.90639730639731 -DTXSID9046285 Css 3compartmentss Human 95% 0.4443 mg/L 0.292 mg/L 1.52157534246575 -DTXSID9046287 Css 3compartmentss Human 95% 0.9182 mg/L 0.5181 mg/L 1.77224474039761 -DTXSID9046289 Css 3compartmentss Human 95% 1.215 mg/L 0.697 mg/L 1.74318507890961 -DTXSID9046310 Css 3compartmentss Human 95% 1.076 mg/L 0.1028 mg/L 10.4669260700389 -DTXSID9046318 Css 3compartmentss Human 95% 2.021 mg/L 3.259e-05 mg/L 62012.8873887696 -DTXSID9046360 Css 3compartmentss Human 95% 31.14 mg/L 57.6 mg/L 0.540625 -DTXSID9046443 Css 3compartmentss Human 95% 0.767 mg/L 0.3716 mg/L 2.06404736275565 -DTXSID9046445 Css 3compartmentss Human 95% 66.77 mg/L 35.63 mg/L 1.87398259893348 -DTXSID9046449 Css 3compartmentss Human 95% 3.788 mg/L 1.848 mg/L 2.04978354978355 -DTXSID9046491 Css 3compartmentss Human 95% 5.801 mg/L 3.613 mg/L 1.60559092167174 -DTXSID9046495 Css 3compartmentss Human 95% 1.034 mg/L 0.5539 mg/L 1.86676295360173 -DTXSID9046497 Css 3compartmentss Human 95% 29.89 mg/L 14.89 mg/L 2.0073875083949 -DTXSID9046499 Css 3compartmentss Human 95% 0.5015 mg/L 0.113 mg/L 4.43805309734513 -DTXSID9046520 Css 3compartmentss Human 95% 4.908 mg/L 3.178 mg/L 1.54436752674638 -DTXSID9046524 Css 3compartmentss Human 95% 0.731 mg/L 0.4603 mg/L 1.58809472083424 -DTXSID9046526 Css 3compartmentss Human 95% 0.4425 mg/L 0.287 mg/L 1.5418118466899 -DTXSID9046528 Css 3compartmentss Human 95% 0.02195 mg/L 0.0002416 mg/L 90.8526490066225 -DTXSID9046570 Css 3compartmentss Human 95% 1.316 mg/L 0.7881 mg/L 1.66983885293744 -DTXSID9046572 Css 3compartmentss Human 95% 4.947 mg/L 2.948 mg/L 1.6780868385346 -DTXSID9046574 Css 3compartmentss Human 95% 6.35 mg/L 4.064 mg/L 1.5625 -DTXSID9046576 Css 3compartmentss Human 95% 15.23 mg/L 0.1476 mg/L 103.184281842818 -DTXSID9046578 Css 3compartmentss Human 95% 542.8 mg/L 324.8 mg/L 1.67118226600985 -DTXSID9046601 Css 3compartmentss Human 95% 6.513 mg/L 4.158 mg/L 1.56637806637807 -DTXSID9046603 Css 3compartmentss Human 95% 6.544 mg/L 4.128 mg/L 1.58527131782946 -DTXSID9046605 Css 3compartmentss Human 95% 5.992 mg/L 3.794 mg/L 1.57933579335793 -DTXSID9046607 Css 3compartmentss Human 95% 3.344 mg/L 2.079 mg/L 1.60846560846561 -DTXSID9046609 Css 3compartmentss Human 95% 5.548 mg/L 4.138 mg/L 1.34074432092798 -DTXSID9046651 Css 3compartmentss Human 95% 4.403 mg/L 2.078 mg/L 2.11886429258903 -DTXSID9046653 Css 3compartmentss Human 95% 9.2 mg/L 5.553 mg/L 1.65676211057086 -DTXSID9046657 Css 3compartmentss Human 95% 5.282 mg/L 3.733 mg/L 1.41494776319314 -DTXSID9046659 Css 3compartmentss Human 95% 5.299 mg/L 0.602 mg/L 8.80232558139535 -DTXSID9046730 Css 3compartmentss Human 95% 9.922 mg/L 6.19 mg/L 1.60290791599354 -DTXSID9046732 Css 3compartmentss Human 95% 6.515 mg/L 4.103 mg/L 1.58786253960517 -DTXSID9046734 Css 3compartmentss Human 95% 0.4415 mg/L 0.3476 mg/L 1.27013808975834 -DTXSID9046736 Css 3compartmentss Human 95% 7.24 mg/L 5.225 mg/L 1.38564593301435 -DTXSID9046738 Css 3compartmentss Human 95% 155.9 mg/L 52.24 mg/L 2.98430321592649 -DTXSID9046780 Css 3compartmentss Human 95% 2.481 mg/L 0.3561 mg/L 6.96714406065712 -DTXSID9046782 Css 3compartmentss Human 95% 16.09 mg/L 6.135 mg/L 2.62265688671557 -DTXSID9046784 Css 3compartmentss Human 95% 0.2375 mg/L 0.1354 mg/L 1.75406203840473 -DTXSID9046786 Css 3compartmentss Human 95% 4.456 mg/L 2.293 mg/L 1.94330571303969 -DTXSID9046788 Css 3compartmentss Human 95% 1.713 mg/L 0.8017 mg/L 2.1367094923288 -DTXSID9046813 Css 3compartmentss Human 95% 2.498 mg/L 1.298 mg/L 1.92449922958398 -DTXSID9046815 Css 3compartmentss Human 95% 7.375 mg/L 4.663 mg/L 1.58159982843663 -DTXSID9046817 Css 3compartmentss Human 95% 14.69 mg/L 5.569 mg/L 2.63781648410846 -DTXSID9046819 Css 3compartmentss Human 95% 0.2781 mg/L 0.1866 mg/L 1.4903536977492 -DTXSID9046861 Css 3compartmentss Human 95% 2.726 mg/L 1.315 mg/L 2.07300380228137 -DTXSID9046863 Css 3compartmentss Human 95% 0.8488 mg/L 0.6405 mg/L 1.32521467603435 -DTXSID9046867 Css 3compartmentss Human 95% 40.82 mg/L 21.38 mg/L 1.90926099158092 -DTXSID9046869 Css 3compartmentss Human 95% 0.1616 mg/L 0.1028 mg/L 1.57198443579767 -DTXSID9046942 Css 3compartmentss Human 95% 8.492 mg/L 0.6821 mg/L 12.4497874211992 -DTXSID9046946 Css 3compartmentss Human 95% 0.3926 mg/L 0.3887 mg/L 1.01003344481605 -DTXSID9046992 Css 3compartmentss Human 95% 2.19 mg/L 0.6494 mg/L 3.37234370187866 -DTXSID9046994 Css 3compartmentss Human 95% 0.2481 mg/L 0.1667 mg/L 1.48830233953209 -DTXSID9047041 Css 3compartmentss Human 95% 1.602 mg/L 0.9056 mg/L 1.76899293286219 -DTXSID9047043 Css 3compartmentss Human 95% 7.632 mg/L 4.818 mg/L 1.5840597758406 -DTXSID9047099 Css 3compartmentss Human 95% 53.88 mg/L 59.01 mg/L 0.913065582104728 -DTXSID9047126 Css 3compartmentss Human 95% 0.1354 mg/L 0.0908 mg/L 1.49118942731278 -DTXSID9047174 Css 3compartmentss Human 95% 12.09 mg/L 3.744 mg/L 3.22916666666667 -DTXSID9047178 Css 3compartmentss Human 95% 0.002823 mg/L 0 mg/L Inf -DTXSID9047201 Css 3compartmentss Human 95% 0.1908 mg/L 0.1375 mg/L 1.38763636363636 -DTXSID9047203 Css 3compartmentss Human 95% 0.4412 mg/L 0.3634 mg/L 1.21408915795267 -DTXSID9047205 Css 3compartmentss Human 95% 6.293 mg/L 0.09966 mg/L 63.144691952639 -DTXSID9047251 Css 3compartmentss Human 95% 52.42 mg/L 34.63 mg/L 1.51371643084031 -DTXSID9047253 Css 3compartmentss Human 95% 127 mg/L 60.87 mg/L 2.0864136684738 -DTXSID9047255 Css 3compartmentss Human 95% 11.8 mg/L 4.301 mg/L 2.74354801209021 -DTXSID9047257 Css 3compartmentss Human 95% 36.68 mg/L 0.152 mg/L 241.315789473684 -DTXSID9047259 Css 3compartmentss Human 95% 9.43 mg/L 3.433 mg/L 2.74686862802214 -DTXSID9047330 Css 3compartmentss Human 95% 12.6 mg/L 5.402 mg/L 2.33246945575713 -DTXSID9047334 Css 3compartmentss Human 95% 2.231 mg/L 2.046 mg/L 1.09042033235582 -DTXSID9047338 Css 3compartmentss Human 95% 8.138 mg/L 4.435 mg/L 1.83494926719278 -DTXSID9047411 Css 3compartmentss Human 95% 15.19 mg/L 3.787 mg/L 4.01109057301294 -DTXSID9047415 Css 3compartmentss Human 95% 1.944 mg/L 1.628 mg/L 1.19410319410319 -DTXSID9047417 Css 3compartmentss Human 95% 5.406 mg/L 3.33 mg/L 1.62342342342342 -DTXSID9047461 Css 3compartmentss Human 95% 1.176 mg/L 0.7804 mg/L 1.50691952844695 -DTXSID9047467 Css 3compartmentss Human 95% 6.515 mg/L 4.146 mg/L 1.57139411480945 -DTXSID9047540 Css 3compartmentss Human 95% 11.33 mg/L 4.584 mg/L 2.4716404886562 -DTXSID9047542 Css 3compartmentss Human 95% 7.075 mg/L 3.927 mg/L 1.80162974280621 -DTXSID9047590 Css 3compartmentss Human 95% 8.68 mg/L 2.785 mg/L 3.11669658886894 -DTXSID9047592 Css 3compartmentss Human 95% 36.47 mg/L 5.81 mg/L 6.27710843373494 -DTXSID9047594 Css 3compartmentss Human 95% 27.5 mg/L 14.62 mg/L 1.88098495212038 -DTXSID9047598 Css 3compartmentss Human 95% 117.7 mg/L 96.07 mg/L 1.22514832934319 -DTXSID9047623 Css 3compartmentss Human 95% 4.306 mg/L 4.238e-05 mg/L 101604.530438886 -DTXSID9047675 Css 3compartmentss Human 95% 2.889 mg/L 2.255 mg/L 1.28115299334812 -DTXSID9047677 Css 3compartmentss Human 95% 4.911 mg/L 3.141 mg/L 1.56351480420248 -DTXSID9047700 Css 3compartmentss Human 95% 1.339 mg/L 1.088 mg/L 1.23069852941176 -DTXSID9047702 Css 3compartmentss Human 95% 1.686 mg/L 1.508 mg/L 1.11803713527851 -DTXSID9047704 Css 3compartmentss Human 95% 17.29 mg/L 11.43 mg/L 1.51268591426072 -DTXSID9047708 Css 3compartmentss Human 95% 1367 mg/L 2958 mg/L 0.462136578769439 -DTXSID9047831 Css 3compartmentss Human 95% 79.43 mg/L 36.12 mg/L 2.19905869324474 -DTXSID9047833 Css 3compartmentss Human 95% 6.94 mg/L 0.09771 mg/L 71.0265070105414 -DTXSID9047835 Css 3compartmentss Human 95% 1.745 mg/L 0.8899 mg/L 1.96089448252613 -DTXSID9047837 Css 3compartmentss Human 95% 1.537 mg/L 0.6679 mg/L 2.30124270100314 -DTXSID9047839 Css 3compartmentss Human 95% 5.925 mg/L 0.04493 mg/L 131.871800578678 -DTXSID9047881 Css 3compartmentss Human 95% 4.256 mg/L 2.276 mg/L 1.86994727592267 -DTXSID9047883 Css 3compartmentss Human 95% 7818 mg/L 9739 mg/L 0.802751822569052 -DTXSID9047885 Css 3compartmentss Human 95% 18.42 mg/L 2.185 mg/L 8.43020594965675 -DTXSID9047887 Css 3compartmentss Human 95% 0.831 mg/L 0.4316 mg/L 1.92539388322521 -DTXSID9047889 Css 3compartmentss Human 95% 7.915 mg/L 4.891 mg/L 1.6182784706604 -DTXSID9047910 Css 3compartmentss Human 95% 0.3123 mg/L 0.1875 mg/L 1.6656 -DTXSID9047918 Css 3compartmentss Human 95% 2.326 mg/L 0.2671 mg/L 8.7083489329839 -DTXSID9047960 Css 3compartmentss Human 95% 4.992 mg/L 2.592 mg/L 1.92592592592593 -DTXSID9047962 Css 3compartmentss Human 95% 3.623 mg/L 1.992 mg/L 1.81877510040161 -DTXSID9047964 Css 3compartmentss Human 95% 0.2777 mg/L 0.1204 mg/L 2.30647840531561 -DTXSID9047966 Css 3compartmentss Human 95% 0.7433 mg/L 9e-09 mg/L 82588888.8888889 -DTXSID9047968 Css 3compartmentss Human 95% 41.1 mg/L 24.67 mg/L 1.66599108228618 -DTXSID9048190 Css 3compartmentss Human 95% 48.63 mg/L 0.05566 mg/L 873.697448796263 -DTXSID9048271 Css 3compartmentss Human 95% 11.12 mg/L 6.729 mg/L 1.6525486699361 -DTXSID9048510 Css 3compartmentss Human 95% 24.04 mg/L 11.17 mg/L 2.15219337511191 -DTXSID9048512 Css 3compartmentss Human 95% 0.9449 mg/L 3.323e-06 mg/L 284351.489617815 -DTXSID9048514 Css 3compartmentss Human 95% 24.34 mg/L 12.48 mg/L 1.95032051282051 -DTXSID9048516 Css 3compartmentss Human 95% 30.93 mg/L 16.36 mg/L 1.89058679706601 -DTXSID9048518 Css 3compartmentss Human 95% 65.52 mg/L 34.87 mg/L 1.87897906509894 -DTXSID9048641 Css 3compartmentss Human 95% 1.432 mg/L 0.9078 mg/L 1.57743996474994 -DTXSID9048643 Css 3compartmentss Human 95% 10.09 mg/L 4.93 mg/L 2.04665314401623 -DTXSID9048645 Css 3compartmentss Human 95% 37.62 mg/L 22.17 mg/L 1.69688768606225 -DTXSID9048647 Css 3compartmentss Human 95% 0.2737 mg/L 0.175 mg/L 1.564 -DTXSID9048649 Css 3compartmentss Human 95% 0.9261 mg/L 0.5264 mg/L 1.7593085106383 -DTXSID9048691 Css 3compartmentss Human 95% 0.0652 mg/L 0.03177 mg/L 2.05225055083412 -DTXSID9048693 Css 3compartmentss Human 95% 0.4293 mg/L 0.3335 mg/L 1.28725637181409 -DTXSID9048695 Css 3compartmentss Human 95% 7.307 mg/L 0.9204 mg/L 7.93893959148197 -DTXSID9048697 Css 3compartmentss Human 95% 0.9688 mg/L 0.001796 mg/L 539.420935412027 -DTXSID9048699 Css 3compartmentss Human 95% 2.815 mg/L 0.3759 mg/L 7.48869380154296 -DTXSID9048720 Css 3compartmentss Human 95% 0.8537 mg/L 0.5771 mg/L 1.47929301680818 -DTXSID9048722 Css 3compartmentss Human 95% 0.1999 mg/L 0.08438 mg/L 2.36904479734534 -DTXSID9048724 Css 3compartmentss Human 95% 58.94 mg/L 31.54 mg/L 1.86873811033608 -DTXSID9048726 Css 3compartmentss Human 95% 0.03841 mg/L 0.02602 mg/L 1.47617217524981 -DTXSID9048728 Css 3compartmentss Human 95% 7.476 mg/L 6.357 mg/L 1.17602642756017 -DTXSID9048772 Css 3compartmentss Human 95% 1.928 mg/L 1.65 mg/L 1.16848484848485 -DTXSID9048774 Css 3compartmentss Human 95% 0.8577 mg/L 0.4587 mg/L 1.86984957488555 -DTXSID9048776 Css 3compartmentss Human 95% 3.323 mg/L 0.3806 mg/L 8.73095112979506 -DTXSID9048778 Css 3compartmentss Human 95% 76.49 mg/L 0.1453 mg/L 526.428079834824 -DTXSID9048801 Css 3compartmentss Human 95% 29.07 mg/L 13.93 mg/L 2.08686288585786 -DTXSID9048803 Css 3compartmentss Human 95% 1.609 mg/L 1.249 mg/L 1.28823058446757 -DTXSID9048805 Css 3compartmentss Human 95% 10.02 mg/L 5.902 mg/L 1.69772958319214 -DTXSID9048807 Css 3compartmentss Human 95% 101.5 mg/L 51.42 mg/L 1.97394010112797 -DTXSID9048809 Css 3compartmentss Human 95% 2751 mg/L 9739 mg/L 0.282472533114283 -DTXSID9048851 Css 3compartmentss Human 95% 0.1635 mg/L 0.0995 mg/L 1.64321608040201 -DTXSID9048853 Css 3compartmentss Human 95% 0.8129 mg/L 0.4196 mg/L 1.93732125834128 -DTXSID9048855 Css 3compartmentss Human 95% 1.064 mg/L 0.7441 mg/L 1.42991533396049 -DTXSID9048857 Css 3compartmentss Human 95% 3.903 mg/L 2.848 mg/L 1.37043539325843 -DTXSID9048859 Css 3compartmentss Human 95% 5.391 mg/L 3.205 mg/L 1.68205928237129 -DTXSID9048930 Css 3compartmentss Human 95% 1.924 mg/L 0.3187 mg/L 6.03702541575149 -DTXSID9048932 Css 3compartmentss Human 95% 4.375 mg/L 0.5767 mg/L 7.58626668978672 -DTXSID9048934 Css 3compartmentss Human 95% 2.181 mg/L 0.817 mg/L 2.66952264381885 -DTXSID9048936 Css 3compartmentss Human 95% 2.198 mg/L 0.5291 mg/L 4.15422415422415 -DTXSID9048938 Css 3compartmentss Human 95% 4.647 mg/L 2.908 mg/L 1.59800550206327 -DTXSID9048980 Css 3compartmentss Human 95% 39.14 mg/L 21.98 mg/L 1.78070973612375 -DTXSID9048982 Css 3compartmentss Human 95% 0.328 mg/L 0.1307 mg/L 2.50956388676358 -DTXSID9048984 Css 3compartmentss Human 95% 45.77 mg/L 24.47 mg/L 1.87045361667348 -DTXSID9048986 Css 3compartmentss Human 95% 5.484 mg/L 3.682 mg/L 1.48940793047257 -DTXSID9048988 Css 3compartmentss Human 95% 2.83 mg/L 0.003119 mg/L 907.342096825906 -DTXSID9049031 Css 3compartmentss Human 95% 35.79 mg/L 9739 mg/L 0.00367491528904405 -DTXSID9049033 Css 3compartmentss Human 95% 30.14 mg/L 9.791 mg/L 3.07833724849351 -DTXSID9049035 Css 3compartmentss Human 95% 27.53 mg/L 13.75 mg/L 2.00218181818182 -DTXSID9049037 Css 3compartmentss Human 95% 10.46 mg/L 0.05739 mg/L 182.26171806935 -DTXSID9049039 Css 3compartmentss Human 95% 1.053 mg/L 0.6477 mg/L 1.62575266327003 -DTXSID9049083 Css 3compartmentss Human 95% 1.364 mg/L 0.9147 mg/L 1.49119930031704 -DTXSID9049243 Css 3compartmentss Human 95% 14.42 mg/L 0.5386 mg/L 26.7731154845897 -DTXSID9049245 Css 3compartmentss Human 95% 2.559 mg/L 7.426e-05 mg/L 34460.0053864799 -DTXSID9049249 Css 3compartmentss Human 95% 1.774 mg/L 0.03914 mg/L 45.3244762391415 -DTXSID9049293 Css 3compartmentss Human 95% 4.258 mg/L 2.649 mg/L 1.60739901849755 -DTXSID9049295 Css 3compartmentss Human 95% 0.2425 mg/L 0.1671 mg/L 1.45122681029324 -DTXSID9049297 Css 3compartmentss Human 95% 0.08162 mg/L 0.05916 mg/L 1.37964841108857 -DTXSID9049299 Css 3compartmentss Human 95% 2.326 mg/L 0.2671 mg/L 8.7083489329839 -DTXSID9049322 Css 3compartmentss Human 95% 0.902 mg/L 0.758 mg/L 1.18997361477573 -DTXSID9049324 Css 3compartmentss Human 95% 4.228 mg/L 2.623 mg/L 1.61189477697293 -DTXSID9049326 Css 3compartmentss Human 95% 5.338 mg/L 3.572 mg/L 1.49440089585666 -DTXSID9049374 Css 3compartmentss Human 95% 0.8187 mg/L 0.5896 mg/L 1.38856852103121 -DTXSID9049376 Css 3compartmentss Human 95% 4.31 mg/L 1.586 mg/L 2.71752837326608 -DTXSID9049401 Css 3compartmentss Human 95% 31.11 mg/L 0.02203 mg/L 1412.16522923286 -DTXSID9049405 Css 3compartmentss Human 95% 1.785 mg/L 1.093 mg/L 1.63311985361391 -DTXSID9049407 Css 3compartmentss Human 95% 1.752 mg/L 1.098 mg/L 1.59562841530055 -DTXSID9049409 Css 3compartmentss Human 95% 7.647 mg/L 4.673 mg/L 1.63642199871603 -DTXSID9051662 Css 3compartmentss Human 95% 6.752 mg/L 4.139 mg/L 1.63131191108964 -DTXSID9051824 Css 3compartmentss Human 95% 2.432 mg/L 1.781 mg/L 1.36552498596294 -DTXSID9052509 Css 3compartmentss Human 95% 2.175 mg/L 1.207 mg/L 1.8019884009942 -DTXSID9057630 Css 3compartmentss Human 95% 9.377 mg/L 5.094 mg/L 1.8407930899097 -DTXSID9057632 Css 3compartmentss Human 95% 5.458 mg/L 3.669 mg/L 1.48759880076315 -DTXSID9057634 Css 3compartmentss Human 95% 11.53 mg/L 6.4 mg/L 1.8015625 -DTXSID9057636 Css 3compartmentss Human 95% 0.8759 mg/L 0.6123 mg/L 1.43050792095378 -DTXSID9057638 Css 3compartmentss Human 95% 9.151 mg/L 4.482 mg/L 2.0417224453369 -DTXSID9057680 Css 3compartmentss Human 95% 0.1379 mg/L 0.09178 mg/L 1.50250599259098 -DTXSID9057682 Css 3compartmentss Human 95% 5.718 mg/L 3.758 mg/L 1.52155401809473 -DTXSID9057684 Css 3compartmentss Human 95% 6.177 mg/L 3.655 mg/L 1.69001367989056 -DTXSID9057686 Css 3compartmentss Human 95% 6.339 mg/L 3.662 mg/L 1.73102129983616 -DTXSID9057711 Css 3compartmentss Human 95% 59.22 mg/L 30.8 mg/L 1.92272727272727 -DTXSID9057713 Css 3compartmentss Human 95% 6.722 mg/L 3.793 mg/L 1.77221196941735 -DTXSID9057715 Css 3compartmentss Human 95% 4.378 mg/L 1.664 mg/L 2.63100961538462 -DTXSID9057717 Css 3compartmentss Human 95% 1.236 mg/L 0.8793 mg/L 1.40566359604231 -DTXSID9057719 Css 3compartmentss Human 95% 36.58 mg/L 2.487 mg/L 14.7084841174105 -DTXSID9057763 Css 3compartmentss Human 95% 0.06652 mg/L 0.04233 mg/L 1.57146231986771 -DTXSID9057765 Css 3compartmentss Human 95% 4.57 mg/L 2.419 mg/L 1.8892104175279 -DTXSID9057767 Css 3compartmentss Human 95% 38.17 mg/L 22.48 mg/L 1.6979537366548 -DTXSID9057769 Css 3compartmentss Human 95% 1.256 mg/L 1.004 mg/L 1.25099601593625 -DTXSID9057840 Css 3compartmentss Human 95% 6.486 mg/L 0.03501 mg/L 185.261353898886 -DTXSID9057842 Css 3compartmentss Human 95% 114.6 mg/L 63.68 mg/L 1.79962311557789 -DTXSID9057844 Css 3compartmentss Human 95% 0.1864 mg/L 1e-09 mg/L 186400000 -DTXSID9057846 Css 3compartmentss Human 95% 58.38 mg/L 32.88 mg/L 1.77554744525547 -DTXSID9057848 Css 3compartmentss Human 95% 1.046 mg/L 0.8496 mg/L 1.23116760828625 -DTXSID9057898 Css 3compartmentss Human 95% 68.03 mg/L 38.86 mg/L 1.75064333504889 -DTXSID9058654 Css 3compartmentss Human 95% 1.824 mg/L 2.867e-06 mg/L 636205.092431113 -DTXSID90858931 Css 3compartmentss Human 95% 0.2593 mg/L 0.1533 mg/L 1.6914546640574 -DTXSID90873366 Css 3compartmentss Human 95% 2.127 mg/L 0.866 mg/L 2.45612009237875 +DTXSID001009966 Css 3compartmentss Human 95% 8.735 mg/L NA NA NA +DTXSID001014436 Css 3compartmentss Human 95% 2.928 mg/L NA NA NA +DTXSID00143784 Css 3compartmentss Human 95% 1.147 mg/L NA NA NA +DTXSID00144539 Css 3compartmentss Human 95% 52.94 mg/L NA NA NA +DTXSID00155842 Css 3compartmentss Human 95% 56.55 mg/L NA NA NA +DTXSID00157169 Css 3compartmentss Human 95% 9.44 mg/L NA NA NA +DTXSID00157826 Css 3compartmentss Human 95% 1.356 mg/L NA NA NA +DTXSID00162475 Css 3compartmentss Human 95% 3.296 mg/L NA NA NA +DTXSID00167364 Css 3compartmentss Human 95% 1.724 mg/L NA NA NA +DTXSID00172913 Css 3compartmentss Human 95% 0.4956 mg/L NA NA NA +DTXSID00178672 Css 3compartmentss Human 95% 0.4952 mg/L NA NA NA +DTXSID00184293 Css 3compartmentss Human 95% 2.744 mg/L NA NA NA +DTXSID00190197 Css 3compartmentss Human 95% 19.43 mg/L NA NA NA +DTXSID00190617 Css 3compartmentss Human 95% 2.118 mg/L NA NA NA +DTXSID00196977 Css 3compartmentss Human 95% 0.8649 mg/L NA NA NA +DTXSID0020020 Css 3compartmentss Human 95% 0.442 mg/L 4.348 mg/L 0.10165593376265 +DTXSID0020022 Css 3compartmentss Human 95% 161.4 mg/L 185.6 mg/L 0.869612068965517 +DTXSID00200503 Css 3compartmentss Human 95% 0.2581 mg/L NA NA NA +DTXSID0020070 Css 3compartmentss Human 95% 1.506 mg/L 1.688 mg/L 0.89218009478673 +DTXSID0020072 Css 3compartmentss Human 95% 2.641 mg/L 4.993 mg/L 0.528940516723413 +DTXSID0020074 Css 3compartmentss Human 95% 2.475 mg/L 3.01 mg/L 0.822259136212625 +DTXSID0020076 Css 3compartmentss Human 95% 1.629 mg/L 2.033 mg/L 0.80127889818003 +DTXSID0020105 Css 3compartmentss Human 95% 5.414 mg/L 6.477 mg/L 0.83588080901652 +DTXSID0020107 Css 3compartmentss Human 95% 5.299 mg/L 5.343 mg/L 0.991764926071495 +DTXSID00201257 Css 3compartmentss Human 95% 2.652 mg/L NA NA NA +DTXSID0020151 Css 3compartmentss Human 95% 0.4968 mg/L 1.136 mg/L 0.437323943661972 +DTXSID0020155 Css 3compartmentss Human 95% 2.721 mg/L NA NA NA +DTXSID0020157 Css 3compartmentss Human 95% 0.8505 mg/L 1.392 mg/L 0.610991379310345 +DTXSID0020232 Css 3compartmentss Human 95% 1.014 mg/L 1.325 mg/L 0.765283018867925 +DTXSID0020236 Css 3compartmentss Human 95% 6.475 mg/L 7.454 mg/L 0.868661121545479 +DTXSID0020238 Css 3compartmentss Human 95% 0.919 mg/L 0.628 mg/L 1.46337579617834 +DTXSID0020280 Css 3compartmentss Human 95% 1.665 mg/L 1.704 mg/L 0.977112676056338 +DTXSID0020282 Css 3compartmentss Human 95% 0.4071 mg/L 3.049 mg/L 0.133519186618563 +DTXSID0020284 Css 3compartmentss Human 95% 0.3918 mg/L 1.463 mg/L 0.267805878332194 +DTXSID0020286 Css 3compartmentss Human 95% 0.33 mg/L 0.3215 mg/L 1.02643856920684 +DTXSID0020288 Css 3compartmentss Human 95% 2.197 mg/L 0.7942 mg/L 2.76630571644422 +DTXSID0020311 Css 3compartmentss Human 95% 1.787 mg/L 1.851 mg/L 0.965424095083738 +DTXSID0020319 Css 3compartmentss Human 95% 19.51 mg/L 20.22 mg/L 0.9648862512364 +DTXSID0020361 Css 3compartmentss Human 95% 1.945 mg/L 2.085 mg/L 0.932853717026379 +DTXSID0020363 Css 3compartmentss Human 95% 4.816 mg/L 5.473 mg/L 0.879956148364699 +DTXSID0020367 Css 3compartmentss Human 95% 6.068 mg/L 5.742 mg/L 1.05677464298154 +DTXSID0020369 Css 3compartmentss Human 95% 5.718 mg/L 1.043 mg/L 5.48226270373921 +DTXSID0020440 Css 3compartmentss Human 95% 754.1 mg/L 796.2 mg/L 0.9471238382316 +DTXSID0020442 Css 3compartmentss Human 95% 43.33 mg/L 112.3 mg/L 0.385841495992876 +DTXSID0020446 Css 3compartmentss Human 95% 1.632 mg/L 2.073 mg/L 0.78726483357453 +DTXSID0020494 Css 3compartmentss Human 95% 5.784 mg/L 5.966 mg/L 0.969493798189742 +DTXSID0020523 Css 3compartmentss Human 95% 246.5 mg/L 235.9 mg/L 1.04493429419245 +DTXSID0020527 Css 3compartmentss Human 95% 4.483 mg/L 4.982 mg/L 0.899839421918908 +DTXSID0020529 Css 3compartmentss Human 95% 47.81 mg/L 50.09 mg/L 0.954481932521461 +DTXSID0020573 Css 3compartmentss Human 95% 8.85 mg/L 9.146 mg/L 0.967636125082003 +DTXSID0020577 Css 3compartmentss Human 95% 0.4192 mg/L 4.509 mg/L 0.0929696163229097 +DTXSID0020602 Css 3compartmentss Human 95% 2.682 mg/L 3.201 mg/L 0.837863167760075 +DTXSID0020604 Css 3compartmentss Human 95% 0.09219 mg/L 0.07548 mg/L 1.22138314785374 +DTXSID0020606 Css 3compartmentss Human 95% 0.1516 mg/L 16.33 mg/L 0.00928352725045928 +DTXSID00206409 Css 3compartmentss Human 95% 20.62 mg/L NA NA NA +DTXSID0020650 Css 3compartmentss Human 95% 6.251 mg/L 11.02 mg/L 0.567241379310345 +DTXSID0020652 Css 3compartmentss Human 95% 4.834 mg/L 4.393 mg/L 1.10038697928523 +DTXSID0020654 Css 3compartmentss Human 95% 0.1382 mg/L NA NA NA +DTXSID0020656 Css 3compartmentss Human 95% 12.13 mg/L 12.6 mg/L 0.962698412698413 +DTXSID0020733 Css 3compartmentss Human 95% 5.137 mg/L 0.2555 mg/L 20.105675146771 +DTXSID0020737 Css 3compartmentss Human 95% 0.6903 mg/L 3.324 mg/L 0.207671480144404 +DTXSID0020785 Css 3compartmentss Human 95% 0.3417 mg/L 0.3467 mg/L 0.985578309777906 +DTXSID0020810 Css 3compartmentss Human 95% 3.016 mg/L 0.8611 mg/L 3.50249680641041 +DTXSID0020814 Css 3compartmentss Human 95% 32.32 mg/L 12.7 mg/L 2.54488188976378 +DTXSID0020818 Css 3compartmentss Human 95% 0.9802 mg/L 1.121 mg/L 0.874397859054416 +DTXSID0020862 Css 3compartmentss Human 95% 18.9 mg/L NA NA NA +DTXSID00208827 Css 3compartmentss Human 95% 4.323 mg/L NA NA NA +DTXSID0020943 Css 3compartmentss Human 95% 0.7506 mg/L 0.7718 mg/L 0.972531743975123 +DTXSID00210203 Css 3compartmentss Human 95% 1.831 mg/L NA NA NA +DTXSID0021040 Css 3compartmentss Human 95% 0.2796 mg/L 2.466 mg/L 0.11338199513382 +DTXSID0021094 Css 3compartmentss Human 95% 9.026 mg/L 9.251 mg/L 0.975678305048103 +DTXSID0021096 Css 3compartmentss Human 95% 3.096 mg/L 1.846 mg/L 1.6771397616468 +DTXSID0021121 Css 3compartmentss Human 95% 0.9666 mg/L 0.3258 mg/L 2.96685082872928 +DTXSID0021123 Css 3compartmentss Human 95% 9.153 mg/L 9.418 mg/L 0.971862391165853 +DTXSID0021125 Css 3compartmentss Human 95% 4.748 mg/L 4.251 mg/L 1.11691366737238 +DTXSID0021127 Css 3compartmentss Human 95% 1.91 mg/L 4.96 mg/L 0.38508064516129 +DTXSID0021129 Css 3compartmentss Human 95% 3.338 mg/L 8.988 mg/L 0.37138406764575 +DTXSID0021179 Css 3compartmentss Human 95% 0.3403 mg/L 0.2228 mg/L 1.52737881508079 +DTXSID0021206 Css 3compartmentss Human 95% 4.973 mg/L 5.697 mg/L 0.872915569598034 +DTXSID0021254 Css 3compartmentss Human 95% 23.58 mg/L NA NA NA +DTXSID0021256 Css 3compartmentss Human 95% 52.36 mg/L 186.9 mg/L 0.280149812734082 +DTXSID0021258 Css 3compartmentss Human 95% 0.9616 mg/L 0.2997 mg/L 3.20854187520854 +DTXSID0021331 Css 3compartmentss Human 95% 2.865 mg/L 3.217 mg/L 0.890581286913273 +DTXSID0021333 Css 3compartmentss Human 95% 0.2015 mg/L 0.2032 mg/L 0.991633858267717 +DTXSID0021335 Css 3compartmentss Human 95% 0.4839 mg/L 1.206 mg/L 0.401243781094527 +DTXSID0021337 Css 3compartmentss Human 95% 33.85 mg/L 35.55 mg/L 0.952180028129395 +DTXSID0021339 Css 3compartmentss Human 95% 0.1775 mg/L 3.271 mg/L 0.0542647508407215 +DTXSID0021387 Css 3compartmentss Human 95% 28.77 mg/L 534.4 mg/L 0.0538360778443114 +DTXSID0021389 Css 3compartmentss Human 95% 0.1408 mg/L 0.1488 mg/L 0.946236559139785 +DTXSID0021410 Css 3compartmentss Human 95% 1.608 mg/L 1.881 mg/L 0.854864433811802 +DTXSID0021414 Css 3compartmentss Human 95% 11.92 mg/L 0.005682 mg/L 2097.8528687082 +DTXSID0021418 Css 3compartmentss Human 95% 8.991 mg/L 4.772 mg/L 1.88411567476949 +DTXSID0021460 Css 3compartmentss Human 95% 0.5059 mg/L 0.8008 mg/L 0.631743256743257 +DTXSID0021462 Css 3compartmentss Human 95% 1.567 mg/L 4.098 mg/L 0.382381649585164 +DTXSID0021464 Css 3compartmentss Human 95% 6.396 mg/L 7.333 mg/L 0.872221464612028 +DTXSID0021545 Css 3compartmentss Human 95% 6.263 mg/L 7.203 mg/L 0.869498819936138 +DTXSID0021547 Css 3compartmentss Human 95% 4.082 mg/L 4.944 mg/L 0.825647249190938 +DTXSID0021626 Css 3compartmentss Human 95% 1.107 mg/L 2.163 mg/L 0.511789181692094 +DTXSID0021628 Css 3compartmentss Human 95% 5.828 mg/L 6.393 mg/L 0.911622086657282 +DTXSID0021709 Css 3compartmentss Human 95% 0.3773 mg/L 1.365 mg/L 0.276410256410256 +DTXSID0021751 Css 3compartmentss Human 95% 6.717 mg/L 7.664 mg/L 0.876435281837161 +DTXSID0021757 Css 3compartmentss Human 95% 0.3636 mg/L 0.8557 mg/L 0.424915274044642 +DTXSID0021759 Css 3compartmentss Human 95% 4.956 mg/L 5.626 mg/L 0.880910060433701 +DTXSID0021830 Css 3compartmentss Human 95% 0.3805 mg/L NA NA NA +DTXSID0021834 Css 3compartmentss Human 95% 1.493 mg/L 1.486 mg/L 1.00471063257066 +DTXSID0021915 Css 3compartmentss Human 95% 6.581 mg/L 4.548 mg/L 1.44700967458223 +DTXSID0021961 Css 3compartmentss Human 95% 7.497 mg/L 7.469 mg/L 1.0037488284911 +DTXSID0021969 Css 3compartmentss Human 95% 0.03512 mg/L 0.03877 mg/L 0.905855042558679 +DTXSID0022012 Css 3compartmentss Human 95% 0.4463 mg/L 0.1986 mg/L 2.2472306143001 +DTXSID0022014 Css 3compartmentss Human 95% 0.5391 mg/L 0.02784 mg/L 19.364224137931 +DTXSID0022016 Css 3compartmentss Human 95% 0.5648 mg/L 0.6631 mg/L 0.851756899411853 +DTXSID0022060 Css 3compartmentss Human 95% 0.6661 mg/L 0.4487 mg/L 1.48451080900379 +DTXSID00220983 Css 3compartmentss Human 95% 1.055 mg/L 1.062 mg/L 0.993408662900188 +DTXSID0022191 Css 3compartmentss Human 95% 0.3621 mg/L NA NA NA +DTXSID0022220 Css 3compartmentss Human 95% 24.7 mg/L 1068 mg/L 0.02312734082397 +DTXSID0022301 Css 3compartmentss Human 95% 18.62 mg/L 2.062 mg/L 9.03006789524733 +DTXSID00223070 Css 3compartmentss Human 95% 2.416 mg/L NA NA NA +DTXSID0022353 Css 3compartmentss Human 95% 102.7 mg/L 105.1 mg/L 0.977164605137964 +DTXSID0022432 Css 3compartmentss Human 95% 22.14 mg/L 4.937 mg/L 4.48450475997569 +DTXSID0022436 Css 3compartmentss Human 95% 11.75 mg/L 14.13 mg/L 0.831564048124558 +DTXSID0022480 Css 3compartmentss Human 95% 0.5904 mg/L 1.418 mg/L 0.416361071932299 +DTXSID0022563 Css 3compartmentss Human 95% 3.77 mg/L 5.729 mg/L 0.658055507069297 +DTXSID0022565 Css 3compartmentss Human 95% 7.368 mg/L 0.9485 mg/L 7.76805482340538 +DTXSID0022569 Css 3compartmentss Human 95% 17.83 mg/L 0.1128 mg/L 158.067375886525 +DTXSID0022640 Css 3compartmentss Human 95% 4.752 mg/L 7.99 mg/L 0.594743429286608 +DTXSID0022644 Css 3compartmentss Human 95% 1.01 mg/L 2.182 mg/L 0.462878093492209 +DTXSID0022646 Css 3compartmentss Human 95% 0.833 mg/L 0.5756 mg/L 1.44718554551772 +DTXSID0022690 Css 3compartmentss Human 95% 3.937 mg/L 3.125 mg/L 1.25984 +DTXSID0022692 Css 3compartmentss Human 95% 2.49 mg/L 12.98 mg/L 0.191833590138675 +DTXSID0022721 Css 3compartmentss Human 95% 13.52 mg/L 0.1195 mg/L 113.138075313808 +DTXSID0022725 Css 3compartmentss Human 95% 145.9 mg/L 285.3 mg/L 0.511391517700666 +DTXSID0022727 Css 3compartmentss Human 95% 137.9 mg/L 0.007759 mg/L 17772.9088800103 +DTXSID0022773 Css 3compartmentss Human 95% 1.188 mg/L NA NA NA +DTXSID0022777 Css 3compartmentss Human 95% 9.144 mg/L 20.44 mg/L 0.447358121330724 +DTXSID0022800 Css 3compartmentss Human 95% 1.032 mg/L 6.983 mg/L 0.147787483889446 +DTXSID0022804 Css 3compartmentss Human 95% 0.6596 mg/L 0.7231 mg/L 0.912183653713179 +DTXSID0022808 Css 3compartmentss Human 95% 1.244 mg/L 2.232 mg/L 0.557347670250896 +DTXSID00228303 Css 3compartmentss Human 95% 0.8973 mg/L NA NA NA +DTXSID0022850 Css 3compartmentss Human 95% 0.3274 mg/L 0.3605 mg/L 0.908183079056866 +DTXSID0022854 Css 3compartmentss Human 95% 3.275 mg/L 7.15 mg/L 0.458041958041958 +DTXSID0022858 Css 3compartmentss Human 95% 9.687 mg/L 0.3765 mg/L 25.7290836653386 +DTXSID0022933 Css 3compartmentss Human 95% 64.7 mg/L 0.03784 mg/L 1709.83086680761 +DTXSID0022935 Css 3compartmentss Human 95% 7.778 mg/L 0.5652 mg/L 13.761500353857 +DTXSID0022981 Css 3compartmentss Human 95% 7.308 mg/L 1.337 mg/L 5.46596858638743 +DTXSID0022983 Css 3compartmentss Human 95% 6.73 mg/L NA NA NA +DTXSID0022985 Css 3compartmentss Human 95% 0.8232 mg/L NA NA NA +DTXSID0022987 Css 3compartmentss Human 95% 6.318 mg/L NA NA NA +DTXSID0022989 Css 3compartmentss Human 95% 13.96 mg/L NA NA NA +DTXSID0023030 Css 3compartmentss Human 95% 3.28 mg/L 11.28 mg/L 0.290780141843972 +DTXSID0023032 Css 3compartmentss Human 95% 2.159 mg/L 23.31 mg/L 0.0926211926211926 +DTXSID0023036 Css 3compartmentss Human 95% 17.66 mg/L 0.7751 mg/L 22.7841568829828 +DTXSID0023038 Css 3compartmentss Human 95% 8.281 mg/L 0.761 mg/L 10.8817345597898 +DTXSID00230663 Css 3compartmentss Human 95% 119.3 mg/L NA NA NA +DTXSID0023080 Css 3compartmentss Human 95% 0.6164 mg/L NA NA NA +DTXSID0023084 Css 3compartmentss Human 95% 1.448 mg/L 0.3012 mg/L 4.8074369189907 +DTXSID0023088 Css 3compartmentss Human 95% 5.209 mg/L 5.669 mg/L 0.918856941259481 +DTXSID0023111 Css 3compartmentss Human 95% 0.8448 mg/L 1.1 mg/L 0.768 +DTXSID0023113 Css 3compartmentss Human 95% 0.09613 mg/L 0.09773 mg/L 0.983628363859613 +DTXSID0023163 Css 3compartmentss Human 95% 2.901 mg/L 5.071 mg/L 0.572076513508184 +DTXSID0023169 Css 3compartmentss Human 95% 29.97 mg/L 3.717 mg/L 8.06295399515738 +DTXSID0023240 Css 3compartmentss Human 95% 0.216 mg/L NA NA NA +DTXSID0023244 Css 3compartmentss Human 95% 2.245 mg/L 2.638 mg/L 0.851023502653525 +DTXSID0023292 Css 3compartmentss Human 95% 0.2727 mg/L 0.1297 mg/L 2.10254433307633 +DTXSID0023294 Css 3compartmentss Human 95% 7.598 mg/L 0.05214 mg/L 145.72305331799 +DTXSID0023296 Css 3compartmentss Human 95% 0.6655 mg/L 3.959 mg/L 0.168098004546603 +DTXSID0023298 Css 3compartmentss Human 95% 1.285 mg/L 0.896 mg/L 1.43415178571429 +DTXSID00233139 Css 3compartmentss Human 95% 22.07 mg/L 20.4 mg/L 1.08186274509804 +DTXSID0023321 Css 3compartmentss Human 95% 1.804 mg/L 1.779 mg/L 1.01405283867341 +DTXSID0023323 Css 3compartmentss Human 95% 2.848 mg/L 5.293 mg/L 0.53806914793123 +DTXSID0023325 Css 3compartmentss Human 95% 5.529 mg/L 5.914 mg/L 0.934900236726412 +DTXSID0023329 Css 3compartmentss Human 95% 3.235 mg/L 0.5186 mg/L 6.23794832240648 +DTXSID0023371 Css 3compartmentss Human 95% 1732 mg/L 1849 mg/L 0.936722552731206 +DTXSID0023373 Css 3compartmentss Human 95% 18.68 mg/L 22.21 mg/L 0.841062584421432 +DTXSID0023377 Css 3compartmentss Human 95% 0.8618 mg/L 1.197 mg/L 0.719966583124478 +DTXSID0023406 Css 3compartmentss Human 95% 30.22 mg/L NA NA NA +DTXSID00234343 Css 3compartmentss Human 95% 53.55 mg/L NA NA NA +DTXSID0023458 Css 3compartmentss Human 95% 3.079 mg/L 4.96 mg/L 0.620766129032258 +DTXSID0023533 Css 3compartmentss Human 95% 4.111 mg/L 0.3841 mg/L 10.7029419422026 +DTXSID0023581 Css 3compartmentss Human 95% 14.21 mg/L 14.63 mg/L 0.971291866028708 +DTXSID0023583 Css 3compartmentss Human 95% 23.65 mg/L NA NA NA +DTXSID0023587 Css 3compartmentss Human 95% 7.406 mg/L 2.826 mg/L 2.6206652512385 +DTXSID0023589 Css 3compartmentss Human 95% 0.7383 mg/L 7.244 mg/L 0.101918829376035 +DTXSID00235971 Css 3compartmentss Human 95% 11.87 mg/L NA NA NA +DTXSID0023612 Css 3compartmentss Human 95% 1.823 mg/L 3.93 mg/L 0.463867684478371 +DTXSID0023616 Css 3compartmentss Human 95% 2.455 mg/L 3.501 mg/L 0.701228220508426 +DTXSID0023618 Css 3compartmentss Human 95% 17.9 mg/L 150.4 mg/L 0.119015957446808 +DTXSID0023660 Css 3compartmentss Human 95% 4.718 mg/L 5.073 mg/L 0.930021683422038 +DTXSID0023668 Css 3compartmentss Human 95% 4.942 mg/L NA NA NA +DTXSID0023743 Css 3compartmentss Human 95% 6.294 mg/L 2.313 mg/L 2.72114137483787 +DTXSID0023745 Css 3compartmentss Human 95% 5.195 mg/L 5.573 mg/L 0.932172976852683 +DTXSID0023747 Css 3compartmentss Human 95% 4.019 mg/L 0.5126 mg/L 7.84042138119391 +DTXSID0023749 Css 3compartmentss Human 95% 0.1294 mg/L 0.161 mg/L 0.803726708074534 +DTXSID0023826 Css 3compartmentss Human 95% 9.077 mg/L 0.9834 mg/L 9.23022167988611 +DTXSID00238609 Css 3compartmentss Human 95% 1.638 mg/L NA NA NA +DTXSID0023870 Css 3compartmentss Human 95% 4.33 mg/L 2.027 mg/L 2.13616181549087 +DTXSID0023901 Css 3compartmentss Human 95% 249.5 mg/L 300.5 mg/L 0.830282861896839 +DTXSID0023907 Css 3compartmentss Human 95% 5.735 mg/L 4.446 mg/L 1.28992352676563 +DTXSID0023909 Css 3compartmentss Human 95% 17.02 mg/L 9.266 mg/L 1.83682279300669 +DTXSID00239373 Css 3compartmentss Human 95% 0.4238 mg/L NA NA NA +DTXSID0023951 Css 3compartmentss Human 95% 0.919 mg/L 0.8648 mg/L 1.06267345050879 +DTXSID0023955 Css 3compartmentss Human 95% 6.797 mg/L 31.47 mg/L 0.21598347632666 +DTXSID0024000 Css 3compartmentss Human 95% 8.56 mg/L 8.283 mg/L 1.03344198961729 +DTXSID0024002 Css 3compartmentss Human 95% 22.72 mg/L 23.04 mg/L 0.986111111111111 +DTXSID0024052 Css 3compartmentss Human 95% 2.164 mg/L 2.056 mg/L 1.05252918287938 +DTXSID0024216 Css 3compartmentss Human 95% 4.227 mg/L NA NA NA +DTXSID0024266 Css 3compartmentss Human 95% 4.914 mg/L 4.775 mg/L 1.02910994764398 +DTXSID0024345 Css 3compartmentss Human 95% 16.66 mg/L 19.29 mg/L 0.863659927423536 +DTXSID0024395 Css 3compartmentss Human 95% 6.142 mg/L 3.084 mg/L 1.99156939040208 +DTXSID0024397 Css 3compartmentss Human 95% 0.4309 mg/L 3.148 mg/L 0.136880559085133 +DTXSID0024399 Css 3compartmentss Human 95% 2.704 mg/L 3.127 mg/L 0.864726574992005 +DTXSID0024470 Css 3compartmentss Human 95% 0.8243 mg/L 3.687 mg/L 0.223569297531869 +DTXSID0024474 Css 3compartmentss Human 95% 6.483 mg/L 9.735 mg/L 0.665947611710324 +DTXSID0024478 Css 3compartmentss Human 95% 1.68 mg/L 3.793 mg/L 0.442921170577379 +DTXSID0024501 Css 3compartmentss Human 95% 11.19 mg/L 134 mg/L 0.0835074626865672 +DTXSID0024503 Css 3compartmentss Human 95% 1.928 mg/L 2.351 mg/L 0.820076563164611 +DTXSID0024505 Css 3compartmentss Human 95% 6.049 mg/L 1.594 mg/L 3.79485570890841 +DTXSID0024507 Css 3compartmentss Human 95% 4.324 mg/L 8.022 mg/L 0.539017701321366 +DTXSID0024509 Css 3compartmentss Human 95% 7.356 mg/L 7.276 mg/L 1.0109950522265 +DTXSID0024553 Css 3compartmentss Human 95% 5.214 mg/L 5.678 mg/L 0.918281084889045 +DTXSID0024559 Css 3compartmentss Human 95% 6.02 mg/L 1.562 mg/L 3.85403329065301 +DTXSID0024761 Css 3compartmentss Human 95% 0.5229 mg/L 1.624 mg/L 0.32198275862069 +DTXSID0024890 Css 3compartmentss Human 95% 0.9277 mg/L 2.629 mg/L 0.352871814378091 +DTXSID0024896 Css 3compartmentss Human 95% 15.92 mg/L 31.11 mg/L 0.51173256187721 +DTXSID0024921 Css 3compartmentss Human 95% 6.24 mg/L 0.09463 mg/L 65.9410334988904 +DTXSID0024923 Css 3compartmentss Human 95% 7.096 mg/L 5.477 mg/L 1.29559978090195 +DTXSID0024977 Css 3compartmentss Human 95% 4.821 mg/L 273.2 mg/L 0.0176464128843338 +DTXSID0024979 Css 3compartmentss Human 95% 16.33 mg/L 69.27 mg/L 0.235744189403782 +DTXSID0025070 Css 3compartmentss Human 95% 0.4522 mg/L 14.73 mg/L 0.0306992532247115 +DTXSID0025074 Css 3compartmentss Human 95% 4.978 mg/L 11.19 mg/L 0.444861483467382 +DTXSID0025076 Css 3compartmentss Human 95% 12.62 mg/L 57.89 mg/L 0.217999654517188 +DTXSID0025078 Css 3compartmentss Human 95% 0.5126 mg/L 32.13 mg/L 0.0159539371304077 +DTXSID0025101 Css 3compartmentss Human 95% 11.79 mg/L 12.41 mg/L 0.950040290088638 +DTXSID0025234 Css 3compartmentss Human 95% 58.54 mg/L 55.42 mg/L 1.056297365572 +DTXSID0025315 Css 3compartmentss Human 95% 8.323 mg/L NA NA NA +DTXSID0025361 Css 3compartmentss Human 95% 0.3053 mg/L 5.937 mg/L 0.0514232777497052 +DTXSID0025363 Css 3compartmentss Human 95% 7.056 mg/L 7.917 mg/L 0.891246684350133 +DTXSID0025367 Css 3compartmentss Human 95% 3.385 mg/L 4.088 mg/L 0.828033268101761 +DTXSID0025440 Css 3compartmentss Human 95% 7.661 mg/L 0.1496 mg/L 51.2098930481283 +DTXSID0025494 Css 3compartmentss Human 95% 20.2 mg/L 1157 mg/L 0.0174589455488332 +DTXSID0025523 Css 3compartmentss Human 95% 0.3404 mg/L 1.741 mg/L 0.195519816197588 +DTXSID0025527 Css 3compartmentss Human 95% 4.074 mg/L 1.447 mg/L 2.8154803040774 +DTXSID0025571 Css 3compartmentss Human 95% 0.3563 mg/L 0.972 mg/L 0.36656378600823 +DTXSID0025600 Css 3compartmentss Human 95% 1.488 mg/L 12.73 mg/L 0.116889238020424 +DTXSID0025654 Css 3compartmentss Human 95% 20.34 mg/L 15.77 mg/L 1.28979074191503 +DTXSID0025733 Css 3compartmentss Human 95% 0.3816 mg/L 3.683 mg/L 0.103611186532718 +DTXSID0025737 Css 3compartmentss Human 95% 0.734 mg/L 15.41 mg/L 0.0476314081765088 +DTXSID0025789 Css 3compartmentss Human 95% 1.148 mg/L 2.299 mg/L 0.499347542409743 +DTXSID0025812 Css 3compartmentss Human 95% 2.111 mg/L 1.283 mg/L 1.64536243180047 +DTXSID0025814 Css 3compartmentss Human 95% 6.4 mg/L 7.443 mg/L 0.859868332661561 +DTXSID0025816 Css 3compartmentss Human 95% 6.502 mg/L 7.701 mg/L 0.844305934294247 +DTXSID0025818 Css 3compartmentss Human 95% 5.431 mg/L 0.6177 mg/L 8.79229399384815 +DTXSID0025862 Css 3compartmentss Human 95% 0.3386 mg/L 0.6826 mg/L 0.49604453559918 +DTXSID0025864 Css 3compartmentss Human 95% 0.336 mg/L 0.3423 mg/L 0.98159509202454 +DTXSID0025866 Css 3compartmentss Human 95% 0.4295 mg/L 0.7899 mg/L 0.543739713887834 +DTXSID0025991 Css 3compartmentss Human 95% 0.4865 mg/L 0.5578 mg/L 0.87217640731445 +DTXSID0025997 Css 3compartmentss Human 95% 10.11 mg/L 14.5 mg/L 0.697241379310345 +DTXSID0026040 Css 3compartmentss Human 95% 0.2463 mg/L 0.2758 mg/L 0.893038433647571 +DTXSID0026044 Css 3compartmentss Human 95% 0.469 mg/L 0.001742 mg/L 269.230769230769 +DTXSID0026098 Css 3compartmentss Human 95% 55.58 mg/L NA NA NA +DTXSID0026125 Css 3compartmentss Human 95% 0.3841 mg/L 6.354 mg/L 0.060450110166824 +DTXSID0026173 Css 3compartmentss Human 95% 7.107 mg/L 3.219 mg/L 2.20782851817335 +DTXSID0026175 Css 3compartmentss Human 95% 7.566 mg/L 0.6566 mg/L 11.5229972586049 +DTXSID0026202 Css 3compartmentss Human 95% 131.6 mg/L 136.1 mg/L 0.966936076414401 +DTXSID0026204 Css 3compartmentss Human 95% 25.33 mg/L 26.73 mg/L 0.947624392068836 +DTXSID0026208 Css 3compartmentss Human 95% 22.56 mg/L 64.14 mg/L 0.351730589335828 +DTXSID0026252 Css 3compartmentss Human 95% 25.7 mg/L 4.887 mg/L 5.25885001023123 +DTXSID0026258 Css 3compartmentss Human 95% 9.017 mg/L 0.04111 mg/L 219.33836049623 +DTXSID0026547 Css 3compartmentss Human 95% 3.572 mg/L 11.47 mg/L 0.311421098517873 +DTXSID0026549 Css 3compartmentss Human 95% 4.923 mg/L 5.575 mg/L 0.88304932735426 +DTXSID0026676 Css 3compartmentss Human 95% 66.64 mg/L 132.8 mg/L 0.501807228915663 +DTXSID0026701 Css 3compartmentss Human 95% 1.055 mg/L 7.666 mg/L 0.137620662666319 +DTXSID0026830 Css 3compartmentss Human 95% 6.55 mg/L 8.27 mg/L 0.792019347037485 +DTXSID0026880 Css 3compartmentss Human 95% 0.2777 mg/L 5.799 mg/L 0.0478875668218658 +DTXSID0026915 Css 3compartmentss Human 95% 12.66 mg/L 8.729 mg/L 1.45033795394661 +DTXSID0026961 Css 3compartmentss Human 95% 1.46 mg/L 19.12 mg/L 0.0763598326359833 +DTXSID0026967 Css 3compartmentss Human 95% 0.07675 mg/L 0.2112 mg/L 0.363399621212121 +DTXSID0027066 Css 3compartmentss Human 95% 22.79 mg/L 110.8 mg/L 0.205685920577617 +DTXSID0027149 Css 3compartmentss Human 95% 6.525 mg/L 7.735 mg/L 0.843568196509373 +DTXSID0027197 Css 3compartmentss Human 95% 4.718 mg/L 5.506 mg/L 0.856883399927352 +DTXSID0027272 Css 3compartmentss Human 95% 0.7009 mg/L NA NA NA +DTXSID0027301 Css 3compartmentss Human 95% 6.3 mg/L 1.503 mg/L 4.19161676646707 +DTXSID0027309 Css 3compartmentss Human 95% 0.3475 mg/L 0.09997 mg/L 3.47604281284385 +DTXSID00274148 Css 3compartmentss Human 95% 3.711 mg/L 2.867 mg/L 1.29438437391001 +DTXSID0027432 Css 3compartmentss Human 95% 6.207 mg/L 5.732 mg/L 1.08286810886253 +DTXSID0027436 Css 3compartmentss Human 95% 7.782 mg/L 7.317 mg/L 1.06355063550636 +DTXSID0027438 Css 3compartmentss Human 95% 7.201 mg/L 0.8902 mg/L 8.08919343967648 +DTXSID0027486 Css 3compartmentss Human 95% 6.245 mg/L 7.381 mg/L 0.8460913155399 +DTXSID0027513 Css 3compartmentss Human 95% 7.45 mg/L 8.384 mg/L 0.888597328244275 +DTXSID0027561 Css 3compartmentss Human 95% 7.297 mg/L 0.03248 mg/L 224.661330049261 +DTXSID0027565 Css 3compartmentss Human 95% 1.21 mg/L 1.24 mg/L 0.975806451612903 +DTXSID0027567 Css 3compartmentss Human 95% 8.287 mg/L 10.46 mg/L 0.79225621414914 +DTXSID0027640 Css 3compartmentss Human 95% 6.369 mg/L 7.122 mg/L 0.894271272114575 +DTXSID0027721 Css 3compartmentss Human 95% 1125 mg/L 60.99 mg/L 18.4456468273487 +DTXSID0027771 Css 3compartmentss Human 95% 14.15 mg/L 54.52 mg/L 0.25953778429934 +DTXSID0027773 Css 3compartmentss Human 95% 1.688 mg/L 38.04 mg/L 0.0443743427970557 +DTXSID0027802 Css 3compartmentss Human 95% 18.77 mg/L 1.666 mg/L 11.2665066026411 +DTXSID0027804 Css 3compartmentss Human 95% 4.796 mg/L 5.37 mg/L 0.893109869646183 +DTXSID0027806 Css 3compartmentss Human 95% 8.148 mg/L 8.439 mg/L 0.96551724137931 +DTXSID0027981 Css 3compartmentss Human 95% 7.494 mg/L 28.89 mg/L 0.259397715472482 +DTXSID0028030 Css 3compartmentss Human 95% 0.9953 mg/L 0.004478 mg/L 222.264403751675 +DTXSID0028038 Css 3compartmentss Human 95% 0.03172 mg/L 0.01517 mg/L 2.09096901779829 +DTXSID0029133 Css 3compartmentss Human 95% 0.4161 mg/L 0.6303 mg/L 0.660161827701095 +DTXSID0029189 Css 3compartmentss Human 95% 5.291 mg/L 5.97 mg/L 0.886264656616416 +DTXSID0029260 Css 3compartmentss Human 95% 5.112 mg/L 5.889 mg/L 0.868059093224656 +DTXSID0029268 Css 3compartmentss Human 95% 3.652 mg/L NA NA NA +DTXSID0029559 Css 3compartmentss Human 95% 4.22 mg/L 0.07002 mg/L 60.2684947157955 +DTXSID0029761 Css 3compartmentss Human 95% 8.217 mg/L 8.329 mg/L 0.986553007563933 +DTXSID0030162 Css 3compartmentss Human 95% 0.3332 mg/L 0.9666 mg/L 0.344713428512311 +DTXSID0030588 Css 3compartmentss Human 95% 6.3 mg/L 0.2277 mg/L 27.6679841897233 +DTXSID0032029 Css 3compartmentss Human 95% 0.9659 mg/L 0.2997 mg/L 3.22288955622289 +DTXSID0032314 Css 3compartmentss Human 95% 3.626 mg/L 4.2 mg/L 0.863333333333333 +DTXSID0032316 Css 3compartmentss Human 95% 3.217 mg/L 3.382 mg/L 0.951212300413956 +DTXSID0032493 Css 3compartmentss Human 95% 43.03 mg/L 44.36 mg/L 0.970018034265104 +DTXSID0032497 Css 3compartmentss Human 95% 52.03 mg/L 306.7 mg/L 0.169644603847408 +DTXSID0032520 Css 3compartmentss Human 95% 3.66 mg/L 3.716 mg/L 0.984930032292788 +DTXSID0032572 Css 3compartmentss Human 95% 11.04 mg/L 4.341 mg/L 2.54319281271596 +DTXSID0032578 Css 3compartmentss Human 95% 0.01356 mg/L 0.01884 mg/L 0.719745222929936 +DTXSID0032601 Css 3compartmentss Human 95% 11.89 mg/L 15.59 mg/L 0.762668377164849 +DTXSID0032605 Css 3compartmentss Human 95% 1832 mg/L 1156 mg/L 1.58477508650519 +DTXSID0032651 Css 3compartmentss Human 95% 184.7 mg/L 226.8 mg/L 0.814373897707231 +DTXSID0032655 Css 3compartmentss Human 95% 5.101 mg/L 7.001 mg/L 0.728610198543065 +DTXSID0032811 Css 3compartmentss Human 95% 7.566 mg/L 8.245 mg/L 0.917647058823529 +DTXSID0032813 Css 3compartmentss Human 95% 0.3484 mg/L 8.716 mg/L 0.0399724644332263 +DTXSID0032998 Css 3compartmentss Human 95% 7.744 mg/L 7.997 mg/L 0.968363136176066 +DTXSID0033047 Css 3compartmentss Human 95% 2.56 mg/L 1.343 mg/L 1.90618019359643 +DTXSID0033332 Css 3compartmentss Human 95% 1.652 mg/L 55.08 mg/L 0.0299927378358751 +DTXSID0033334 Css 3compartmentss Human 95% 42.02 mg/L 0.4446 mg/L 94.5119208277103 +DTXSID0033382 Css 3compartmentss Human 95% 9.939 mg/L 4.339 mg/L 2.29061995851579 +DTXSID00334554 Css 3compartmentss Human 95% 3.573 mg/L NA NA NA +DTXSID0033469 Css 3compartmentss Human 95% 7.496 mg/L 8.744 mg/L 0.857273559011894 +DTXSID0033673 Css 3compartmentss Human 95% 0.2966 mg/L 6.093 mg/L 0.0486788117511899 +DTXSID0033754 Css 3compartmentss Human 95% 4.348 mg/L 3.24 mg/L 1.34197530864198 +DTXSID0033960 Css 3compartmentss Human 95% 89.67 mg/L 103.5 mg/L 0.866376811594203 +DTXSID00341081 Css 3compartmentss Human 95% 0.668 mg/L NA NA NA +DTXSID00341147 Css 3compartmentss Human 95% 4.3 mg/L NA NA NA +DTXSID0034192 Css 3compartmentss Human 95% 0.9626 mg/L 1.061 mg/L 0.907257304429783 +DTXSID0034223 Css 3compartmentss Human 95% 17.71 mg/L 17.12 mg/L 1.03446261682243 +DTXSID0034227 Css 3compartmentss Human 95% 0.6431 mg/L 0.6025 mg/L 1.06738589211618 +DTXSID0034229 Css 3compartmentss Human 95% 0.6528 mg/L 12.08 mg/L 0.0540397350993378 +DTXSID00342871 Css 3compartmentss Human 95% 16.13 mg/L NA NA NA +DTXSID0034300 Css 3compartmentss Human 95% 8.899 mg/L 9.199 mg/L 0.96738775953908 +DTXSID0034518 Css 3compartmentss Human 95% 15.21 mg/L 3.683 mg/L 4.12978550095031 +DTXSID0034566 Css 3compartmentss Human 95% 4938 mg/L 4415 mg/L 1.11845979614949 +DTXSID0034722 Css 3compartmentss Human 95% 4.243 mg/L 82.05 mg/L 0.0517123705057892 +DTXSID0034776 Css 3compartmentss Human 95% 18.68 mg/L 1.629 mg/L 11.4671577655003 +DTXSID0034803 Css 3compartmentss Human 95% 496.1 mg/L 673.1 mg/L 0.737037587282722 +DTXSID0034851 Css 3compartmentss Human 95% 5.082 mg/L 293.4 mg/L 0.017321063394683 +DTXSID0034855 Css 3compartmentss Human 95% 2.063 mg/L 1.82 mg/L 1.13351648351648 +DTXSID0034857 Css 3compartmentss Human 95% 20.63 mg/L NA NA NA +DTXSID0034930 Css 3compartmentss Human 95% 7.586 mg/L 7.646 mg/L 0.99215275961287 +DTXSID0034936 Css 3compartmentss Human 95% 4.938 mg/L 14 mg/L 0.352714285714286 +DTXSID0035748 Css 3compartmentss Human 95% 7.019 mg/L 5.194 mg/L 1.35136696187909 +DTXSID0035790 Css 3compartmentss Human 95% 0.5237 mg/L 0.5889 mg/L 0.889285107828154 +DTXSID0036508 Css 3compartmentss Human 95% 3.919 mg/L 5.17 mg/L 0.758027079303675 +DTXSID0037023 Css 3compartmentss Human 95% 2.352 mg/L 4.393 mg/L 0.535397222854541 +DTXSID0037231 Css 3compartmentss Human 95% 64.36 mg/L 33.34 mg/L 1.93041391721656 +DTXSID0037237 Css 3compartmentss Human 95% 33.65 mg/L 35.31 mg/L 0.952987822146701 +DTXSID0037493 Css 3compartmentss Human 95% 0.9789 mg/L 0.7761 mg/L 1.26130653266332 +DTXSID0037495 Css 3compartmentss Human 95% 7.137 mg/L 7.646 mg/L 0.933429244049176 +DTXSID0037522 Css 3compartmentss Human 95% 15.74 mg/L 2.888 mg/L 5.45013850415512 +DTXSID0037570 Css 3compartmentss Human 95% 1.901 mg/L 0.9177 mg/L 2.07148305546475 +DTXSID0037576 Css 3compartmentss Human 95% 11.92 mg/L 12.6 mg/L 0.946031746031746 +DTXSID0037653 Css 3compartmentss Human 95% 7.496 mg/L NA NA NA +DTXSID0037730 Css 3compartmentss Human 95% 3.542 mg/L 21.62 mg/L 0.163829787234043 +DTXSID0037734 Css 3compartmentss Human 95% 14.6 mg/L 112 mg/L 0.130357142857143 +DTXSID0038338 Css 3compartmentss Human 95% 16.84 mg/L NA NA NA +DTXSID0038700 Css 3compartmentss Human 95% 0.5723 mg/L 0.3288 mg/L 1.74057177615572 +DTXSID0038831 Css 3compartmentss Human 95% 5.782 mg/L 7.255 mg/L 0.79696760854583 +DTXSID0038839 Css 3compartmentss Human 95% 1.452 mg/L 1.284 mg/L 1.13084112149533 +DTXSID0038881 Css 3compartmentss Human 95% 3.067 mg/L 9.519 mg/L 0.322197709843471 +DTXSID0038887 Css 3compartmentss Human 95% 14.81 mg/L 20.22 mg/L 0.7324431256182 +DTXSID00391122 Css 3compartmentss Human 95% 5.16 mg/L NA NA NA +DTXSID0039223 Css 3compartmentss Human 95% 7.122 mg/L 7.562 mg/L 0.941814334832055 +DTXSID0039227 Css 3compartmentss Human 95% 4.53 mg/L 11.12 mg/L 0.407374100719425 +DTXSID0039229 Css 3compartmentss Human 95% 7.135 mg/L 8.257 mg/L 0.864115296112389 +DTXSID0040123 Css 3compartmentss Human 95% 2.426 mg/L NA NA NA +DTXSID0040127 Css 3compartmentss Human 95% 4.674 mg/L 3.318 mg/L 1.40867992766727 +DTXSID0040129 Css 3compartmentss Human 95% 6.634 mg/L 0.08942 mg/L 74.1892194140013 +DTXSID0040208 Css 3compartmentss Human 95% 2.538 mg/L 6.84 mg/L 0.371052631578947 +DTXSID0040464 Css 3compartmentss Human 95% 6.578 mg/L 0.3481 mg/L 18.8968687158862 +DTXSID0040547 Css 3compartmentss Human 95% 5.51 mg/L 10.13 mg/L 0.543928923988154 +DTXSID0040599 Css 3compartmentss Human 95% 13.29 mg/L 0.3902 mg/L 34.0594566888775 +DTXSID0040620 Css 3compartmentss Human 95% 3.32 mg/L 5.666 mg/L 0.585951288386869 +DTXSID0040622 Css 3compartmentss Human 95% 8.526 mg/L 1.112 mg/L 7.66726618705036 +DTXSID0040672 Css 3compartmentss Human 95% 4.816 mg/L 13.75 mg/L 0.350254545454545 +DTXSID0040674 Css 3compartmentss Human 95% 11.63 mg/L 3.612 mg/L 3.21982281284607 +DTXSID0040676 Css 3compartmentss Human 95% 100.5 mg/L 113.6 mg/L 0.884683098591549 +DTXSID0040678 Css 3compartmentss Human 95% 2.902 mg/L 75.32 mg/L 0.0385289431757833 +DTXSID0040701 Css 3compartmentss Human 95% 0.4681 mg/L 0.1207 mg/L 3.87821043910522 +DTXSID0040703 Css 3compartmentss Human 95% 4.361 mg/L 100.6 mg/L 0.0433499005964215 +DTXSID0040705 Css 3compartmentss Human 95% 18.51 mg/L 187.4 mg/L 0.0987726787620064 +DTXSID0040707 Css 3compartmentss Human 95% 7.588 mg/L 7.879 mg/L 0.963066378982104 +DTXSID0040751 Css 3compartmentss Human 95% 14.39 mg/L 119 mg/L 0.120924369747899 +DTXSID0040755 Css 3compartmentss Human 95% 0.7644 mg/L 0.7618 mg/L 1.00341296928328 +DTXSID0040757 Css 3compartmentss Human 95% 15.02 mg/L 122.4 mg/L 0.122712418300654 +DTXSID0041060 Css 3compartmentss Human 95% 0.8203 mg/L 1.238 mg/L 0.662600969305331 +DTXSID0041068 Css 3compartmentss Human 95% 29.75 mg/L NA NA NA +DTXSID0041141 Css 3compartmentss Human 95% 2.952 mg/L 1.363 mg/L 2.16581071166544 +DTXSID0041145 Css 3compartmentss Human 95% 1.811 mg/L NA NA NA +DTXSID0041197 Css 3compartmentss Human 95% 6.256 mg/L 620 mg/L 0.0100903225806452 +DTXSID0041220 Css 3compartmentss Human 95% 8.719 mg/L 3.24 mg/L 2.69104938271605 +DTXSID0041224 Css 3compartmentss Human 95% 5.615 mg/L 5.484 mg/L 1.02388767323122 +DTXSID0041274 Css 3compartmentss Human 95% 1.61 mg/L 2.287 mg/L 0.703979011805859 +DTXSID0041359 Css 3compartmentss Human 95% 3.125 mg/L 12.97 mg/L 0.240940632228219 +DTXSID0041436 Css 3compartmentss Human 95% 6.728 mg/L 5.689 mg/L 1.18263315169626 +DTXSID0041513 Css 3compartmentss Human 95% 6.23 mg/L 1.204 mg/L 5.17441860465116 +DTXSID0041517 Css 3compartmentss Human 95% 0.3114 mg/L 5.54 mg/L 0.0562093862815884 +DTXSID0041567 Css 3compartmentss Human 95% 6.965 mg/L 568 mg/L 0.012262323943662 +DTXSID0041646 Css 3compartmentss Human 95% 6.827 mg/L 89.49 mg/L 0.0762878533914404 +DTXSID0041692 Css 3compartmentss Human 95% 0.2804 mg/L 0.4418 mg/L 0.634676324128565 +DTXSID0041698 Css 3compartmentss Human 95% 5.652 mg/L 0.3037 mg/L 18.6104708594007 +DTXSID0041850 Css 3compartmentss Human 95% 6.502 mg/L 1.873 mg/L 3.47143619861185 +DTXSID0041852 Css 3compartmentss Human 95% 7.746 mg/L 36.34 mg/L 0.213153549807375 +DTXSID0041981 Css 3compartmentss Human 95% 7.581 mg/L 8.864 mg/L 0.855257220216606 +DTXSID0041983 Css 3compartmentss Human 95% 36.49 mg/L 5.1 mg/L 7.15490196078431 +DTXSID0041985 Css 3compartmentss Human 95% 17.45 mg/L 22.86 mg/L 0.76334208223972 +DTXSID0041987 Css 3compartmentss Human 95% 7.168 mg/L 16.78 mg/L 0.427175208581645 +DTXSID0042080 Css 3compartmentss Human 95% 15.79 mg/L 2.298 mg/L 6.87119234116623 +DTXSID0042084 Css 3compartmentss Human 95% 0.8896 mg/L 0.4146 mg/L 2.1456825856247 +DTXSID0042117 Css 3compartmentss Human 95% 1.287 mg/L 0.2464 mg/L 5.22321428571429 +DTXSID0042167 Css 3compartmentss Human 95% 5.294 mg/L 11.87 mg/L 0.445998315080034 +DTXSID0042169 Css 3compartmentss Human 95% 1.247 mg/L 4.142 mg/L 0.301062288749396 +DTXSID0042242 Css 3compartmentss Human 95% 0.5142 mg/L 2.293 mg/L 0.224247710423027 +DTXSID0042244 Css 3compartmentss Human 95% 6.838 mg/L 10.12 mg/L 0.675691699604743 +DTXSID0042248 Css 3compartmentss Human 95% 0.9348 mg/L 1.527 mg/L 0.612180746561886 +DTXSID0042400 Css 3compartmentss Human 95% 2.496 mg/L 187.2 mg/L 0.0133333333333333 +DTXSID0042406 Css 3compartmentss Human 95% 7.88 mg/L 9.595 mg/L 0.821261073475769 +DTXSID0042454 Css 3compartmentss Human 95% 20.1 mg/L 1745 mg/L 0.0115186246418338 +DTXSID0042583 Css 3compartmentss Human 95% 0.4477 mg/L 1.986 mg/L 0.225427995971803 +DTXSID0042612 Css 3compartmentss Human 95% 1.591 mg/L 2.332 mg/L 0.682246998284734 +DTXSID0042614 Css 3compartmentss Human 95% 1.392 mg/L 1.696 mg/L 0.820754716981132 +DTXSID0042618 Css 3compartmentss Human 95% 1.004 mg/L 0.3652 mg/L 2.74917853231106 +DTXSID0042668 Css 3compartmentss Human 95% 5.672 mg/L 6.531 mg/L 0.868473434389833 +DTXSID0043761 Css 3compartmentss Human 95% 18.74 mg/L 141.3 mg/L 0.132625619249823 +DTXSID0043763 Css 3compartmentss Human 95% 4.773 mg/L 0.6055 mg/L 7.88274153592073 +DTXSID0043765 Css 3compartmentss Human 95% 6.269 mg/L 0.06118 mg/L 102.468126838836 +DTXSID0043848 Css 3compartmentss Human 95% 0.2365 mg/L 0.0546 mg/L 4.33150183150183 +DTXSID0043892 Css 3compartmentss Human 95% 2.755 mg/L 11.02 mg/L 0.25 +DTXSID0043896 Css 3compartmentss Human 95% 5.033 mg/L 35.79 mg/L 0.140625873148924 +DTXSID0044024 Css 3compartmentss Human 95% 14.46 mg/L 39.74 mg/L 0.363865123301459 +DTXSID0044107 Css 3compartmentss Human 95% 5.323 mg/L 45.41 mg/L 0.11722087645893 +DTXSID0044236 Css 3compartmentss Human 95% 16.43 mg/L 11230 mg/L 0.00146304541406946 +DTXSID0044280 Css 3compartmentss Human 95% 3.749 mg/L 1.186 mg/L 3.1610455311973 +DTXSID0044288 Css 3compartmentss Human 95% 27.51 mg/L 16.02 mg/L 1.71722846441948 +DTXSID0044315 Css 3compartmentss Human 95% 26.94 mg/L 30.23 mg/L 0.891167714191201 +DTXSID0044361 Css 3compartmentss Human 95% 1.146 mg/L 1.172 mg/L 0.977815699658703 +DTXSID0044365 Css 3compartmentss Human 95% 4.298 mg/L 4.868 mg/L 0.88290879211175 +DTXSID0044369 Css 3compartmentss Human 95% 6.882 mg/L 0.3983 mg/L 17.2784333417022 +DTXSID0044440 Css 3compartmentss Human 95% 13.41 mg/L 4.956 mg/L 2.70581113801453 +DTXSID0044446 Css 3compartmentss Human 95% 2.956 mg/L 3.377 mg/L 0.875333135919455 +DTXSID0044448 Css 3compartmentss Human 95% 6.19 mg/L 7.56 mg/L 0.818783068783069 +DTXSID0044490 Css 3compartmentss Human 95% 9.907 mg/L 2.638 mg/L 3.75549658832449 +DTXSID0044494 Css 3compartmentss Human 95% 7.854 mg/L 2.723 mg/L 2.88431876606684 +DTXSID0044496 Css 3compartmentss Human 95% 1.087 mg/L 23.82 mg/L 0.0456339210747271 +DTXSID0044521 Css 3compartmentss Human 95% 0.6586 mg/L 0.9031 mg/L 0.729265862030783 +DTXSID0044523 Css 3compartmentss Human 95% 8.182 mg/L 7.714 mg/L 1.06066891366347 +DTXSID0044527 Css 3compartmentss Human 95% 8.085 mg/L 6.536 mg/L 1.23699510403917 +DTXSID0044571 Css 3compartmentss Human 95% 1.744 mg/L 1.71 mg/L 1.01988304093567 +DTXSID0044575 Css 3compartmentss Human 95% 3.476 mg/L 6.602 mg/L 0.526507119054832 +DTXSID0044600 Css 3compartmentss Human 95% 0.3474 mg/L 6.835 mg/L 0.0508266276517922 +DTXSID0044604 Css 3compartmentss Human 95% 3.972 mg/L NA NA NA +DTXSID0044606 Css 3compartmentss Human 95% 1.424 mg/L 0.3199 mg/L 4.45139105970616 +DTXSID0044608 Css 3compartmentss Human 95% 0.3712 mg/L NA NA NA +DTXSID0044650 Css 3compartmentss Human 95% 8.427 mg/L 0.2485 mg/L 33.9114688128773 +DTXSID0044654 Css 3compartmentss Human 95% 1.485 mg/L 0.7882 mg/L 1.88403958386196 +DTXSID0044656 Css 3compartmentss Human 95% 6.763 mg/L 0.2076 mg/L 32.5770712909441 +DTXSID0044658 Css 3compartmentss Human 95% 8.253 mg/L 2.278 mg/L 3.62291483757682 +DTXSID0044731 Css 3compartmentss Human 95% 1.64 mg/L 68.55 mg/L 0.0239241429613421 +DTXSID0044733 Css 3compartmentss Human 95% 0.7046 mg/L 15.41 mg/L 0.0457235561323816 +DTXSID0044735 Css 3compartmentss Human 95% 7.63 mg/L 9.05 mg/L 0.843093922651934 +DTXSID0044737 Css 3compartmentss Human 95% 1.126 mg/L 1.57 mg/L 0.717197452229299 +DTXSID0044785 Css 3compartmentss Human 95% 10.08 mg/L 6.147 mg/L 1.6398243045388 +DTXSID0044787 Css 3compartmentss Human 95% 16.35 mg/L 279.9 mg/L 0.0584137191854234 +DTXSID0044812 Css 3compartmentss Human 95% 0.2855 mg/L 5.162 mg/L 0.0553080201472297 +DTXSID0044818 Css 3compartmentss Human 95% 492.6 mg/L 236.9 mg/L 2.0793583790629 +DTXSID0044860 Css 3compartmentss Human 95% 0.2676 mg/L 1.833 mg/L 0.145990180032733 +DTXSID0044862 Css 3compartmentss Human 95% 11.9 mg/L 13.15 mg/L 0.904942965779468 +DTXSID0044868 Css 3compartmentss Human 95% 0.4361 mg/L 3.681 mg/L 0.118473240967128 +DTXSID0044941 Css 3compartmentss Human 95% 2.373 mg/L 6.133 mg/L 0.386923202347954 +DTXSID0044943 Css 3compartmentss Human 95% 6.353 mg/L 2.876 mg/L 2.20897079276773 +DTXSID0044945 Css 3compartmentss Human 95% 7.424 mg/L 0.0632 mg/L 117.46835443038 +DTXSID0044947 Css 3compartmentss Human 95% 5.548 mg/L 5.746 mg/L 0.965541246084232 +DTXSID0044949 Css 3compartmentss Human 95% 6.018 mg/L 5.645 mg/L 1.06607617360496 +DTXSID0044993 Css 3compartmentss Human 95% 1.363 mg/L 3.382 mg/L 0.403015966883501 +DTXSID0044995 Css 3compartmentss Human 95% 7.118 mg/L 21.18 mg/L 0.336071765816808 +DTXSID0044997 Css 3compartmentss Human 95% 64.75 mg/L 1.712 mg/L 37.821261682243 +DTXSID0044999 Css 3compartmentss Human 95% 9.244 mg/L 5.658 mg/L 1.63379285966773 +DTXSID0045090 Css 3compartmentss Human 95% 1.235 mg/L 1.29 mg/L 0.957364341085271 +DTXSID0045094 Css 3compartmentss Human 95% 13.25 mg/L 45.32 mg/L 0.292365401588703 +DTXSID0045096 Css 3compartmentss Human 95% 0.9171 mg/L 2.384 mg/L 0.384689597315436 +DTXSID0045125 Css 3compartmentss Human 95% 6.177 mg/L 231.1 mg/L 0.026728688879273 +DTXSID0045127 Css 3compartmentss Human 95% 0.11 mg/L 0.1207 mg/L 0.911350455675228 +DTXSID0045171 Css 3compartmentss Human 95% 5.718 mg/L 0.9043 mg/L 6.32312285745881 +DTXSID0045173 Css 3compartmentss Human 95% 5.238 mg/L 7.48 mg/L 0.700267379679144 +DTXSID0045175 Css 3compartmentss Human 95% 0.3983 mg/L 0.06667 mg/L 5.9742012899355 +DTXSID0045179 Css 3compartmentss Human 95% 0.3423 mg/L 2.386 mg/L 0.143461860854987 +DTXSID0045202 Css 3compartmentss Human 95% 0.3613 mg/L 0.5134 mg/L 0.703739774055318 +DTXSID0045204 Css 3compartmentss Human 95% 7.322 mg/L 0.01684 mg/L 434.79809976247 +DTXSID0045206 Css 3compartmentss Human 95% 6.075 mg/L 2.77 mg/L 2.19314079422383 +DTXSID0045208 Css 3compartmentss Human 95% 1.119 mg/L 5.722 mg/L 0.195560992659909 +DTXSID0045250 Css 3compartmentss Human 95% 7.793 mg/L 2.543 mg/L 3.06449075894613 +DTXSID0045252 Css 3compartmentss Human 95% 4.276 mg/L 10.06 mg/L 0.425049701789264 +DTXSID0045254 Css 3compartmentss Human 95% 2.604 mg/L 3.071 mg/L 0.847932269619017 +DTXSID0045383 Css 3compartmentss Human 95% 0.65 mg/L 0.1381 mg/L 4.70673425054308 +DTXSID0045385 Css 3compartmentss Human 95% 6.207 mg/L 5.139 mg/L 1.20782253356684 +DTXSID0045389 Css 3compartmentss Human 95% 6.145 mg/L 156.3 mg/L 0.0393154190658989 +DTXSID0045410 Css 3compartmentss Human 95% 1.845 mg/L NA NA NA +DTXSID0045412 Css 3compartmentss Human 95% 4.535 mg/L 5.667 mg/L 0.800247044291512 +DTXSID0045414 Css 3compartmentss Human 95% 25.56 mg/L 239.2 mg/L 0.10685618729097 +DTXSID0045416 Css 3compartmentss Human 95% 1.78 mg/L 0.9346 mg/L 1.90455809972181 +DTXSID0045460 Css 3compartmentss Human 95% 6.862 mg/L 26.22 mg/L 0.261708619374523 +DTXSID0045462 Css 3compartmentss Human 95% 19.86 mg/L 94.76 mg/L 0.209582102152807 +DTXSID0045464 Css 3compartmentss Human 95% 0.4104 mg/L 0.7149 mg/L 0.574066302979438 +DTXSID0045466 Css 3compartmentss Human 95% 0.4393 mg/L 0.3366 mg/L 1.30510992275698 +DTXSID0045468 Css 3compartmentss Human 95% 1.07 mg/L 0.9811 mg/L 1.09061257771889 +DTXSID0045543 Css 3compartmentss Human 95% 0.9876 mg/L 0.2362 mg/L 4.18120237087214 +DTXSID0045547 Css 3compartmentss Human 95% 0.923 mg/L 0.8528 mg/L 1.08231707317073 +DTXSID0045591 Css 3compartmentss Human 95% 0.5864 mg/L 0.149 mg/L 3.93557046979866 +DTXSID0045595 Css 3compartmentss Human 95% 10.79 mg/L 12.26 mg/L 0.880097879282218 +DTXSID0045597 Css 3compartmentss Human 95% 0.6569 mg/L 124.8 mg/L 0.0052636217948718 +DTXSID0045599 Css 3compartmentss Human 95% 5.047 mg/L 8.059 mg/L 0.626256359349795 +DTXSID0045624 Css 3compartmentss Human 95% 6.975 mg/L 5.623 mg/L 1.24044104570514 +DTXSID0045626 Css 3compartmentss Human 95% 0.9396 mg/L 9.761 mg/L 0.0962606290339105 +DTXSID0045670 Css 3compartmentss Human 95% 3.163 mg/L 5.538 mg/L 0.571144817623691 +DTXSID0045674 Css 3compartmentss Human 95% 1.509 mg/L 0.9925 mg/L 1.52040302267002 +DTXSID0045676 Css 3compartmentss Human 95% 4.781 mg/L 8.063 mg/L 0.592955475629418 +DTXSID0045678 Css 3compartmentss Human 95% 4.399 mg/L 0.03789 mg/L 116.099234626551 +DTXSID0045701 Css 3compartmentss Human 95% 1.048 mg/L 0.4016 mg/L 2.60956175298805 +DTXSID0045703 Css 3compartmentss Human 95% 2.246 mg/L 1.74 mg/L 1.29080459770115 +DTXSID0045705 Css 3compartmentss Human 95% 0.7947 mg/L 0.1016 mg/L 7.82185039370079 +DTXSID0045707 Css 3compartmentss Human 95% 0.8071 mg/L 0.9319 mg/L 0.866080051507673 +DTXSID0045709 Css 3compartmentss Human 95% 1.166 mg/L 1.061 mg/L 1.09896324222432 +DTXSID0045751 Css 3compartmentss Human 95% 7.63 mg/L 8.695 mg/L 0.877515813686026 +DTXSID0045753 Css 3compartmentss Human 95% 3.474 mg/L 0.8627 mg/L 4.02689231482555 +DTXSID0045755 Css 3compartmentss Human 95% 4.167 mg/L 6.075 mg/L 0.685925925925926 +DTXSID0045757 Css 3compartmentss Human 95% 10.27 mg/L 19.17 mg/L 0.535732916014606 +DTXSID0045759 Css 3compartmentss Human 95% 4.143 mg/L 6.004 mg/L 0.690039973351099 +DTXSID0045830 Css 3compartmentss Human 95% 0.4047 mg/L 7.016 mg/L 0.0576824401368301 +DTXSID0045832 Css 3compartmentss Human 95% 4.327 mg/L 6.352 mg/L 0.681202770780856 +DTXSID0045836 Css 3compartmentss Human 95% 0.6338 mg/L 7.16 mg/L 0.0885195530726257 +DTXSID0045838 Css 3compartmentss Human 95% 3.632 mg/L 2.096 mg/L 1.73282442748092 +DTXSID0045880 Css 3compartmentss Human 95% 1.95 mg/L 2.267 mg/L 0.860167622408469 +DTXSID0045886 Css 3compartmentss Human 95% 0.3819 mg/L 1.247 mg/L 0.306255012028869 +DTXSID0045888 Css 3compartmentss Human 95% 8.693 mg/L 5.117 mg/L 1.69884698065273 +DTXSID0045961 Css 3compartmentss Human 95% 0.3201 mg/L 0.3226 mg/L 0.992250464972102 +DTXSID0045963 Css 3compartmentss Human 95% 0.6488 mg/L 0.04678 mg/L 13.8691748610517 +DTXSID0045965 Css 3compartmentss Human 95% 2.389 mg/L 2.515 mg/L 0.949900596421471 +DTXSID0045967 Css 3compartmentss Human 95% 10.26 mg/L 13.42 mg/L 0.764530551415797 +DTXSID0046010 Css 3compartmentss Human 95% 6.745 mg/L 5.727 mg/L 1.17775449624585 +DTXSID0046012 Css 3compartmentss Human 95% 5.319 mg/L 5.815 mg/L 0.914703353396389 +DTXSID0046016 Css 3compartmentss Human 95% 4.216 mg/L 4.877 mg/L 0.864465860159934 +DTXSID0046060 Css 3compartmentss Human 95% 1.721 mg/L 0.8538 mg/L 2.01569454204732 +DTXSID0046062 Css 3compartmentss Human 95% 2.996 mg/L 40.61 mg/L 0.073774932282689 +DTXSID0046064 Css 3compartmentss Human 95% 5.068 mg/L 5.573 mg/L 0.909384532567737 +DTXSID0046066 Css 3compartmentss Human 95% 0.2208 mg/L 1.141 mg/L 0.193514460999124 +DTXSID0046143 Css 3compartmentss Human 95% 18.48 mg/L 4.897 mg/L 3.77373902389218 +DTXSID0046145 Css 3compartmentss Human 95% 1.215 mg/L 1.022 mg/L 1.18884540117417 +DTXSID0046147 Css 3compartmentss Human 95% 5.623 mg/L 0.6834 mg/L 8.22797775826749 +DTXSID0046191 Css 3compartmentss Human 95% 0.4113 mg/L 0.2202 mg/L 1.86784741144414 +DTXSID0046193 Css 3compartmentss Human 95% 0.2272 mg/L 0.3697 mg/L 0.61455233973492 +DTXSID0046195 Css 3compartmentss Human 95% 1.141 mg/L 0.01377 mg/L 82.8612926652142 +DTXSID0046197 Css 3compartmentss Human 95% 9.603 mg/L 1.738 mg/L 5.5253164556962 +DTXSID0046199 Css 3compartmentss Human 95% 2.953 mg/L 3.912 mg/L 0.754856850715746 +DTXSID0046220 Css 3compartmentss Human 95% 2.09 mg/L 5.976 mg/L 0.349732262382865 +DTXSID0046222 Css 3compartmentss Human 95% 1.242 mg/L 2.103 mg/L 0.59058487874465 +DTXSID0046224 Css 3compartmentss Human 95% 4.315 mg/L 5.126 mg/L 0.84178696839641 +DTXSID0046226 Css 3compartmentss Human 95% 6.479 mg/L 21.42 mg/L 0.302474323062558 +DTXSID0046228 Css 3compartmentss Human 95% 13.35 mg/L 474.7 mg/L 0.0281230250684643 +DTXSID0046270 Css 3compartmentss Human 95% 1.587 mg/L 0.3802 mg/L 4.17411888479748 +DTXSID0046272 Css 3compartmentss Human 95% 4.584 mg/L 3.83 mg/L 1.19686684073107 +DTXSID0046274 Css 3compartmentss Human 95% 1.096 mg/L 0.2337 mg/L 4.68977321352161 +DTXSID0046276 Css 3compartmentss Human 95% 3.48 mg/L 52.23 mg/L 0.0666283744974153 +DTXSID0046305 Css 3compartmentss Human 95% 1.707 mg/L 2.544 mg/L 0.670990566037736 +DTXSID0046307 Css 3compartmentss Human 95% 1.353 mg/L 5.612 mg/L 0.241090520313614 +DTXSID0046309 Css 3compartmentss Human 95% 13.87 mg/L 4.06 mg/L 3.41625615763547 +DTXSID0046351 Css 3compartmentss Human 95% 0.9631 mg/L 1.278 mg/L 0.753599374021909 +DTXSID0046353 Css 3compartmentss Human 95% 0.5888 mg/L 1.105 mg/L 0.532850678733032 +DTXSID0046357 Css 3compartmentss Human 95% 4.718 mg/L 989.3 mg/L 0.00476902860608511 +DTXSID0046430 Css 3compartmentss Human 95% 4.306 mg/L 3.478 mg/L 1.23806785508913 +DTXSID0046432 Css 3compartmentss Human 95% 0.9501 mg/L 1.087 mg/L 0.874057037718491 +DTXSID0046434 Css 3compartmentss Human 95% 1.722 mg/L 0.06036 mg/L 28.5288270377734 +DTXSID0046438 Css 3compartmentss Human 95% 1.593 mg/L 59.93 mg/L 0.0265810111797097 +DTXSID0046480 Css 3compartmentss Human 95% 1.182 mg/L 6.116 mg/L 0.193263570961413 +DTXSID0046482 Css 3compartmentss Human 95% 59.65 mg/L 11.41 mg/L 5.22787028921998 +DTXSID0046484 Css 3compartmentss Human 95% 1.922 mg/L 0.2881 mg/L 6.67129468934398 +DTXSID0046486 Css 3compartmentss Human 95% 4.216 mg/L 2.283 mg/L 1.8466929478756 +DTXSID0046488 Css 3compartmentss Human 95% 11.89 mg/L 9.168 mg/L 1.29690226876091 +DTXSID0046517 Css 3compartmentss Human 95% 4.897 mg/L 0.6614 mg/L 7.40399153311158 +DTXSID0046561 Css 3compartmentss Human 95% 3.121 mg/L 0.1439 mg/L 21.6886726893676 +DTXSID0046563 Css 3compartmentss Human 95% 0.345 mg/L 0.07976 mg/L 4.32547642928786 +DTXSID0046565 Css 3compartmentss Human 95% 25.75 mg/L 39.48 mg/L 0.652228976697062 +DTXSID0046567 Css 3compartmentss Human 95% 1.023 mg/L 0.9765 mg/L 1.04761904761905 +DTXSID0046569 Css 3compartmentss Human 95% 6.04 mg/L 1.061 mg/L 5.69274269557022 +DTXSID0046640 Css 3compartmentss Human 95% 15.72 mg/L 47.14 mg/L 0.333474756045821 +DTXSID0046642 Css 3compartmentss Human 95% 25.17 mg/L 13.83 mg/L 1.81995661605206 +DTXSID0046644 Css 3compartmentss Human 95% 20.84 mg/L 289.4 mg/L 0.0720110573600553 +DTXSID0046646 Css 3compartmentss Human 95% 6.116 mg/L 11.2 mg/L 0.546071428571429 +DTXSID0046648 Css 3compartmentss Human 95% 16 mg/L 2.657 mg/L 6.02182913059842 +DTXSID0046690 Css 3compartmentss Human 95% 13.21 mg/L 11.51 mg/L 1.14769765421373 +DTXSID0046692 Css 3compartmentss Human 95% 0.9815 mg/L 0.7633 mg/L 1.28586401152889 +DTXSID0046694 Css 3compartmentss Human 95% 2.747 mg/L 4.753 mg/L 0.57795076793604 +DTXSID0046696 Css 3compartmentss Human 95% 1.037 mg/L 1.601 mg/L 0.647720174890693 +DTXSID0046698 Css 3compartmentss Human 95% 1.392 mg/L 1.074 mg/L 1.29608938547486 +DTXSID0046721 Css 3compartmentss Human 95% 9.337 mg/L 7.732 mg/L 1.20757889291257 +DTXSID0046723 Css 3compartmentss Human 95% 40.48 mg/L 46.43 mg/L 0.871850096920095 +DTXSID0046725 Css 3compartmentss Human 95% 2.491 mg/L 22.83 mg/L 0.109110819097679 +DTXSID0046727 Css 3compartmentss Human 95% 10.17 mg/L 1.959 mg/L 5.19142419601838 +DTXSID0046729 Css 3compartmentss Human 95% 40.18 mg/L 47.09 mg/L 0.853259715438522 +DTXSID0046773 Css 3compartmentss Human 95% 2.391 mg/L 6.095 mg/L 0.392288761279737 +DTXSID0046777 Css 3compartmentss Human 95% 2.326 mg/L 4.415 mg/L 0.526840317100793 +DTXSID0046779 Css 3compartmentss Human 95% 5.201 mg/L 1.321 mg/L 3.93716881150643 +DTXSID0046800 Css 3compartmentss Human 95% 1.023 mg/L 11.79 mg/L 0.0867684478371501 +DTXSID0046804 Css 3compartmentss Human 95% 9.791 mg/L 15.78 mg/L 0.620468948035488 +DTXSID0046806 Css 3compartmentss Human 95% 10.93 mg/L 3.4 mg/L 3.21470588235294 +DTXSID0046808 Css 3compartmentss Human 95% 3.761 mg/L 8.442 mg/L 0.445510542525468 +DTXSID0046850 Css 3compartmentss Human 95% 0.9119 mg/L 0.2337 mg/L 3.90201112537441 +DTXSID0046852 Css 3compartmentss Human 95% 3.095 mg/L 8.897 mg/L 0.347870068562437 +DTXSID0046856 Css 3compartmentss Human 95% 0.8005 mg/L 0.2957 mg/L 2.70713561041596 +DTXSID0046858 Css 3compartmentss Human 95% 3.051 mg/L 1.196 mg/L 2.55100334448161 +DTXSID00469037 Css 3compartmentss Human 95% 1.143 mg/L NA NA NA +DTXSID00469774 Css 3compartmentss Human 95% 5.2 mg/L NA NA NA +DTXSID0046989 Css 3compartmentss Human 95% 8.991 mg/L 4.772 mg/L 1.88411567476949 +DTXSID0047030 Css 3compartmentss Human 95% 6.429 mg/L 7.454 mg/L 0.862489938288167 +DTXSID0047034 Css 3compartmentss Human 95% 9.392 mg/L NA NA NA +DTXSID0047036 Css 3compartmentss Human 95% 6.146 mg/L 0.3567 mg/L 17.2301654051023 +DTXSID0047038 Css 3compartmentss Human 95% 0.6353 mg/L 1.014 mg/L 0.626528599605523 +DTXSID0047080 Css 3compartmentss Human 95% 0.8434 mg/L NA NA NA +DTXSID0047082 Css 3compartmentss Human 95% 0.4373 mg/L NA NA NA +DTXSID0047084 Css 3compartmentss Human 95% 0.3351 mg/L 2.051 mg/L 0.163383715260848 +DTXSID0047111 Css 3compartmentss Human 95% 15.86 mg/L 5.776 mg/L 2.74584487534626 +DTXSID0047115 Css 3compartmentss Human 95% 11.7 mg/L 10.82 mg/L 1.08133086876155 +DTXSID0047161 Css 3compartmentss Human 95% 0.785 mg/L 0.2485 mg/L 3.158953722334 +DTXSID0047163 Css 3compartmentss Human 95% 2.225 mg/L NA NA NA +DTXSID0047165 Css 3compartmentss Human 95% 0.6783 mg/L 0.3265 mg/L 2.07748851454824 +DTXSID0047167 Css 3compartmentss Human 95% 3.028 mg/L 3.575 mg/L 0.846993006993007 +DTXSID0047169 Css 3compartmentss Human 95% 0.5822 mg/L NA NA NA +DTXSID0047246 Css 3compartmentss Human 95% 442.9 mg/L 451.4 mg/L 0.981169694284448 +DTXSID0047248 Css 3compartmentss Human 95% 3.294 mg/L 2.58 mg/L 1.27674418604651 +DTXSID0047290 Css 3compartmentss Human 95% 3.331 mg/L 0.116 mg/L 28.7155172413793 +DTXSID0047292 Css 3compartmentss Human 95% 9.598 mg/L NA NA NA +DTXSID0047294 Css 3compartmentss Human 95% 6.756 mg/L 6.376 mg/L 1.05959849435383 +DTXSID0047296 Css 3compartmentss Human 95% 36.52 mg/L 87.74 mg/L 0.416229769774333 +DTXSID0047298 Css 3compartmentss Human 95% 33.94 mg/L NA NA NA +DTXSID0047325 Css 3compartmentss Human 95% 3.125 mg/L 0.833 mg/L 3.7515006002401 +DTXSID0047371 Css 3compartmentss Human 95% 8.22 mg/L 1.695 mg/L 4.84955752212389 +DTXSID0047375 Css 3compartmentss Human 95% 9.937 mg/L 370 mg/L 0.0268567567567568 +DTXSID0047377 Css 3compartmentss Human 95% 9.493 mg/L 1.586 mg/L 5.98549810844893 +DTXSID0047379 Css 3compartmentss Human 95% 18.2 mg/L NA NA NA +DTXSID0047404 Css 3compartmentss Human 95% 0.982 mg/L 1.121 mg/L 0.87600356824264 +DTXSID0047406 Css 3compartmentss Human 95% 17.61 mg/L 17.22 mg/L 1.02264808362369 +DTXSID0047450 Css 3compartmentss Human 95% 1.643 mg/L 20.65 mg/L 0.0795641646489104 +DTXSID0047454 Css 3compartmentss Human 95% 8.209 mg/L 8.522 mg/L 0.963271532504107 +DTXSID0047456 Css 3compartmentss Human 95% 7.007 mg/L 0.6857 mg/L 10.2187545573866 +DTXSID0047535 Css 3compartmentss Human 95% 9.491 mg/L 0.3867 mg/L 24.5435738298423 +DTXSID0047539 Css 3compartmentss Human 95% 31.01 mg/L 5.51 mg/L 5.62794918330309 +DTXSID0047589 Css 3compartmentss Human 95% 2.188 mg/L 4.964 mg/L 0.440773569701853 +DTXSID0047610 Css 3compartmentss Human 95% 0.6064 mg/L NA NA NA +DTXSID0047618 Css 3compartmentss Human 95% 4.239 mg/L 5.151 mg/L 0.822947000582411 +DTXSID0047660 Css 3compartmentss Human 95% 7.808 mg/L 3.089 mg/L 2.52767886047265 +DTXSID0047662 Css 3compartmentss Human 95% 1.571 mg/L 1.421 mg/L 1.10555946516538 +DTXSID0047745 Css 3compartmentss Human 95% 0.414 mg/L 0.9936 mg/L 0.416666666666667 +DTXSID0047797 Css 3compartmentss Human 95% 1.441 mg/L 4.5 mg/L 0.320222222222222 +DTXSID0047799 Css 3compartmentss Human 95% 3.234 mg/L 1676 mg/L 0.00192959427207637 +DTXSID0047820 Css 3compartmentss Human 95% 0.4316 mg/L 0.2553 mg/L 1.69056012534273 +DTXSID0047822 Css 3compartmentss Human 95% 0.3191 mg/L 0.3718 mg/L 0.858257127487897 +DTXSID0047828 Css 3compartmentss Human 95% 1.131 mg/L 0.7045 mg/L 1.60539389638041 +DTXSID0047872 Css 3compartmentss Human 95% 6.734 mg/L 0.2741 mg/L 24.5676760306457 +DTXSID0047874 Css 3compartmentss Human 95% 22.28 mg/L NA NA NA +DTXSID0047876 Css 3compartmentss Human 95% 2.093 mg/L 48.54 mg/L 0.0431190770498558 +DTXSID0047878 Css 3compartmentss Human 95% 7.144 mg/L 0.06329 mg/L 112.877231790172 +DTXSID0047901 Css 3compartmentss Human 95% 8.073 mg/L 9.973 mg/L 0.809485611150105 +DTXSID0047903 Css 3compartmentss Human 95% 7.992 mg/L 9.973 mg/L 0.801363681941241 +DTXSID0047957 Css 3compartmentss Human 95% 12.73 mg/L 3.546 mg/L 3.58996051889453 +DTXSID0048181 Css 3compartmentss Human 95% 1.95 mg/L 2.039 mg/L 0.956351152525748 +DTXSID0048183 Css 3compartmentss Human 95% 2.986 mg/L 2.798 mg/L 1.06719085060758 +DTXSID0048185 Css 3compartmentss Human 95% 3.053 mg/L 2.933 mg/L 1.04091374019775 +DTXSID0048189 Css 3compartmentss Human 95% 12180 mg/L 13700 mg/L 0.889051094890511 +DTXSID0048210 Css 3compartmentss Human 95% 14.55 mg/L 4.675 mg/L 3.11229946524064 +DTXSID0048216 Css 3compartmentss Human 95% 31.3 mg/L NA NA NA +DTXSID0048262 Css 3compartmentss Human 95% 0.1387 mg/L NA NA NA +DTXSID0048349 Css 3compartmentss Human 95% 7.541 mg/L 8.135 mg/L 0.926982175783651 +DTXSID0048505 Css 3compartmentss Human 95% 247.6 mg/L 254.9 mg/L 0.971361318163986 +DTXSID0048507 Css 3compartmentss Human 95% 0.9985 mg/L 0.5128 mg/L 1.94715288611544 +DTXSID0048509 Css 3compartmentss Human 95% 1.769 mg/L 0.7574 mg/L 2.33562186427251 +DTXSID0048632 Css 3compartmentss Human 95% 1.307 mg/L 0.348 mg/L 3.75574712643678 +DTXSID0048634 Css 3compartmentss Human 95% 4.349 mg/L 1.411 mg/L 3.0822111977321 +DTXSID0048636 Css 3compartmentss Human 95% 4.897 mg/L 0.00439 mg/L 1115.48974943052 +DTXSID0048638 Css 3compartmentss Human 95% 1.622 mg/L 3.475 mg/L 0.466762589928058 +DTXSID0048680 Css 3compartmentss Human 95% 6.863 mg/L 11.6 mg/L 0.591637931034483 +DTXSID0048682 Css 3compartmentss Human 95% 0.1264 mg/L 0.1276 mg/L 0.990595611285267 +DTXSID0048684 Css 3compartmentss Human 95% 14.72 mg/L 36.09 mg/L 0.407869215849266 +DTXSID0048686 Css 3compartmentss Human 95% 12.04 mg/L 0.5346 mg/L 22.5215114104003 +DTXSID0048688 Css 3compartmentss Human 95% 22.7 mg/L 52.44 mg/L 0.432875667429443 +DTXSID0048711 Css 3compartmentss Human 95% 5.097 mg/L 5.625 mg/L 0.906133333333333 +DTXSID0048713 Css 3compartmentss Human 95% 9.568 mg/L 1.511 mg/L 6.33223031105228 +DTXSID0048715 Css 3compartmentss Human 95% 2.535 mg/L 1.568 mg/L 1.61670918367347 +DTXSID0048717 Css 3compartmentss Human 95% 3.204 mg/L 5.772 mg/L 0.555093555093555 +DTXSID0048719 Css 3compartmentss Human 95% 12.81 mg/L 3.079 mg/L 4.16044170185125 +DTXSID0048761 Css 3compartmentss Human 95% 4.974 mg/L 0.1614 mg/L 30.817843866171 +DTXSID0048763 Css 3compartmentss Human 95% 154.5 mg/L 181.3 mg/L 0.852178709321566 +DTXSID0048765 Css 3compartmentss Human 95% 0.8926 mg/L 4.124 mg/L 0.216440349175558 +DTXSID0048769 Css 3compartmentss Human 95% 3.077 mg/L 0.4296 mg/L 7.16247672253259 +DTXSID0048840 Css 3compartmentss Human 95% 0.7782 mg/L 0.03712 mg/L 20.9644396551724 +DTXSID0048842 Css 3compartmentss Human 95% 10.91 mg/L 0.8038 mg/L 13.5730281164469 +DTXSID0048844 Css 3compartmentss Human 95% 1.3 mg/L 5.366 mg/L 0.242266120014909 +DTXSID0048846 Css 3compartmentss Human 95% 12.7 mg/L 5.107 mg/L 2.48678284707265 +DTXSID0048848 Css 3compartmentss Human 95% 7.066 mg/L 0.4206 mg/L 16.7998097955302 +DTXSID0048890 Css 3compartmentss Human 95% 6.189 mg/L 0.008528 mg/L 725.727016885553 +DTXSID0048892 Css 3compartmentss Human 95% 0.8524 mg/L 0.08431 mg/L 10.1103071996204 +DTXSID0048894 Css 3compartmentss Human 95% 8.021 mg/L 0.5074 mg/L 15.8080409932992 +DTXSID0048896 Css 3compartmentss Human 95% 1 mg/L 1.004 mg/L 0.99601593625498 +DTXSID0048898 Css 3compartmentss Human 95% 3.759 mg/L 6.264 mg/L 0.600095785440613 +DTXSID0048921 Css 3compartmentss Human 95% 0.3009 mg/L 1.304 mg/L 0.230751533742331 +DTXSID0048923 Css 3compartmentss Human 95% 0.392 mg/L 7.38 mg/L 0.0531165311653117 +DTXSID0048925 Css 3compartmentss Human 95% 1.045 mg/L 1.347 mg/L 0.775798069784707 +DTXSID0048927 Css 3compartmentss Human 95% 1.593 mg/L 0.4878 mg/L 3.26568265682657 +DTXSID0048929 Css 3compartmentss Human 95% 5.311 mg/L 9.571 mg/L 0.554905443527322 +DTXSID0048971 Css 3compartmentss Human 95% 11.4 mg/L 2.271 mg/L 5.01981505944518 +DTXSID0048973 Css 3compartmentss Human 95% 7.277 mg/L 6.967 mg/L 1.04449547868523 +DTXSID0048975 Css 3compartmentss Human 95% 0.6713 mg/L 7.923 mg/L 0.0847280070680298 +DTXSID0048977 Css 3compartmentss Human 95% 8.01 mg/L 0.1059 mg/L 75.6373937677054 +DTXSID0048979 Css 3compartmentss Human 95% 0.8926 mg/L 1.623 mg/L 0.549969192852742 +DTXSID0049022 Css 3compartmentss Human 95% 0.8715 mg/L 0.3259 mg/L 2.67413316968395 +DTXSID0049024 Css 3compartmentss Human 95% 7.36 mg/L 1.587 mg/L 4.63768115942029 +DTXSID0049026 Css 3compartmentss Human 95% 4.634 mg/L 17.98 mg/L 0.257730812013348 +DTXSID0049028 Css 3compartmentss Human 95% 7.474 mg/L 0.127 mg/L 58.8503937007874 +DTXSID0049070 Css 3compartmentss Human 95% 0.486 mg/L 0.5748 mg/L 0.845511482254697 +DTXSID0049072 Css 3compartmentss Human 95% 0.9421 mg/L 0.6429 mg/L 1.46539119614248 +DTXSID0049074 Css 3compartmentss Human 95% 5.305 mg/L 1.206 mg/L 4.39883913764511 +DTXSID0049076 Css 3compartmentss Human 95% 7.613 mg/L 195.5 mg/L 0.0389411764705882 +DTXSID0049078 Css 3compartmentss Human 95% 7.291 mg/L 109.6 mg/L 0.0665237226277372 +DTXSID0049280 Css 3compartmentss Human 95% 12.27 mg/L 0.1482 mg/L 82.7935222672065 +DTXSID0049286 Css 3compartmentss Human 95% 5.644 mg/L 0.2741 mg/L 20.5910251732944 +DTXSID0049288 Css 3compartmentss Human 95% 0.249 mg/L 1.201 mg/L 0.207327227310575 +DTXSID0049311 Css 3compartmentss Human 95% 1.121 mg/L 2.361 mg/L 0.474798814061838 +DTXSID0049313 Css 3compartmentss Human 95% 0.6245 mg/L 4.478 mg/L 0.139459580169719 +DTXSID0049315 Css 3compartmentss Human 95% 2.465 mg/L 4.11 mg/L 0.599756690997567 +DTXSID0050423 Css 3compartmentss Human 95% 3.361 mg/L 49.36 mg/L 0.0680915721231767 +DTXSID0050425 Css 3compartmentss Human 95% 6.288 mg/L 5.708 mg/L 1.10161177295025 +DTXSID0051447 Css 3compartmentss Human 95% 7.197 mg/L 0.646 mg/L 11.140866873065 +DTXSID0051493 Css 3compartmentss Human 95% 5.797 mg/L 2.335 mg/L 2.48265524625268 +DTXSID0051497 Css 3compartmentss Human 95% 1.93 mg/L 5.417 mg/L 0.356285767029721 +DTXSID0051499 Css 3compartmentss Human 95% 0.4031 mg/L 1.063 mg/L 0.379209783631232 +DTXSID0051524 Css 3compartmentss Human 95% 0.6774 mg/L NA NA NA +DTXSID0051526 Css 3compartmentss Human 95% 0.5356 mg/L NA NA NA +DTXSID0051528 Css 3compartmentss Human 95% 0.3678 mg/L NA NA NA +DTXSID0051732 Css 3compartmentss Human 95% 1.293 mg/L 1.289 mg/L 1.00310318076028 +DTXSID0051782 Css 3compartmentss Human 95% 2.084 mg/L 2.082 mg/L 1.00096061479347 +DTXSID0051863 Css 3compartmentss Human 95% 4.905 mg/L 0.1298 mg/L 37.788906009245 +DTXSID0051942 Css 3compartmentss Human 95% 10.18 mg/L NA NA NA +DTXSID0051944 Css 3compartmentss Human 95% 4.972 mg/L 4.78 mg/L 1.04016736401674 +DTXSID0051946 Css 3compartmentss Human 95% 7.938 mg/L NA NA NA +DTXSID0051996 Css 3compartmentss Human 95% 1.682 mg/L 0.9186 mg/L 1.83104724580884 +DTXSID0052043 Css 3compartmentss Human 95% 6.692 mg/L 2.899 mg/L 2.30838220075888 +DTXSID0052045 Css 3compartmentss Human 95% 2.994 mg/L NA NA NA +DTXSID0052124 Css 3compartmentss Human 95% 1.848 mg/L 2.197 mg/L 0.841147018661812 +DTXSID0052463 Css 3compartmentss Human 95% 8.887 mg/L 6.782 mg/L 1.31038041875553 +DTXSID0052542 Css 3compartmentss Human 95% 4.382 mg/L 5.179 mg/L 0.846109287507241 +DTXSID0052594 Css 3compartmentss Human 95% 0.6702 mg/L 0.8758 mg/L 0.765243206211464 +DTXSID0052596 Css 3compartmentss Human 95% 0.5492 mg/L 0.4458 mg/L 1.23194257514581 +DTXSID0052598 Css 3compartmentss Human 95% 6.579 mg/L 4.137 mg/L 1.59028281363307 +DTXSID0052621 Css 3compartmentss Human 95% 1.86 mg/L NA NA NA +DTXSID0052629 Css 3compartmentss Human 95% 0.5667 mg/L NA NA NA +DTXSID0052673 Css 3compartmentss Human 95% 0.9406 mg/L NA NA NA +DTXSID0052831 Css 3compartmentss Human 95% 19.15 mg/L NA NA NA +DTXSID0052837 Css 3compartmentss Human 95% 0.9183 mg/L 2.239 mg/L 0.410138454667262 +DTXSID0052839 Css 3compartmentss Human 95% 7.209 mg/L 4.937 mg/L 1.46019850111404 +DTXSID0057621 Css 3compartmentss Human 95% 1.061 mg/L 1.333 mg/L 0.795948987246812 +DTXSID0057625 Css 3compartmentss Human 95% 20.95 mg/L 0.6524 mg/L 32.1122011036174 +DTXSID0057627 Css 3compartmentss Human 95% 1.848 mg/L 0.8986 mg/L 2.05653238370799 +DTXSID0057629 Css 3compartmentss Human 95% 6.865 mg/L 1.016 mg/L 6.75688976377953 +DTXSID0057671 Css 3compartmentss Human 95% 3.186 mg/L 2.722 mg/L 1.1704628949302 +DTXSID0057673 Css 3compartmentss Human 95% 3.54 mg/L 94.82 mg/L 0.0373338958025733 +DTXSID0057677 Css 3compartmentss Human 95% 19.92 mg/L 11.34 mg/L 1.75661375661376 +DTXSID0057679 Css 3compartmentss Human 95% 0.9897 mg/L 0.318 mg/L 3.1122641509434 +DTXSID0057700 Css 3compartmentss Human 95% 0.7058 mg/L 0.928 mg/L 0.760560344827586 +DTXSID0057702 Css 3compartmentss Human 95% 4.01 mg/L 6.861 mg/L 0.584462906281883 +DTXSID0057704 Css 3compartmentss Human 95% 4.702 mg/L 2.028 mg/L 2.31854043392505 +DTXSID0057706 Css 3compartmentss Human 95% 3.62 mg/L 20.29 mg/L 0.178413011335633 +DTXSID0057708 Css 3compartmentss Human 95% 0.7425 mg/L 1.36 mg/L 0.545955882352941 +DTXSID0057750 Css 3compartmentss Human 95% 23.52 mg/L 119.9 mg/L 0.196163469557965 +DTXSID0057752 Css 3compartmentss Human 95% 2.329 mg/L NA NA NA +DTXSID0057754 Css 3compartmentss Human 95% 8.404 mg/L 8.93 mg/L 0.941097424412094 +DTXSID0057756 Css 3compartmentss Human 95% 0.4089 mg/L 0.01516 mg/L 26.9722955145119 +DTXSID0057758 Css 3compartmentss Human 95% 12.75 mg/L 4.282 mg/L 2.97758056982718 +DTXSID0057831 Css 3compartmentss Human 95% 7.37 mg/L 7.461 mg/L 0.987803243533038 +DTXSID0057833 Css 3compartmentss Human 95% 0.5615 mg/L 0.2208 mg/L 2.54302536231884 +DTXSID0057835 Css 3compartmentss Human 95% 1.208 mg/L 0.3924 mg/L 3.07849133537207 +DTXSID0057837 Css 3compartmentss Human 95% 1.864 mg/L 23.23 mg/L 0.0802410675850194 +DTXSID0057839 Css 3compartmentss Human 95% 0.6729 mg/L 2.401 mg/L 0.280258225739275 +DTXSID0057883 Css 3compartmentss Human 95% 1.497 mg/L NA NA NA +DTXSID0057887 Css 3compartmentss Human 95% 7.358 mg/L NA NA NA +DTXSID0058699 Css 3compartmentss Human 95% 18.94 mg/L NA NA NA +DTXSID0058720 Css 3compartmentss Human 95% 0.4227 mg/L NA NA NA +DTXSID0060800 Css 3compartmentss Human 95% 7.3 mg/L NA NA NA +DTXSID00622706 Css 3compartmentss Human 95% 7 mg/L NA NA NA +DTXSID00676880 Css 3compartmentss Human 95% 1.811 mg/L NA NA NA +DTXSID00677236 Css 3compartmentss Human 95% 0.9152 mg/L NA NA NA +DTXSID00858846 Css 3compartmentss Human 95% 6.731 mg/L NA NA NA +DTXSID00859151 Css 3compartmentss Human 95% 10.5 mg/L 12.12 mg/L 0.866336633663366 +DTXSID00860388 Css 3compartmentss Human 95% 1.994 mg/L NA NA NA +DTXSID00861411 Css 3compartmentss Human 95% 10.97 mg/L NA NA NA +DTXSID00861835 Css 3compartmentss Human 95% 7.434 mg/L NA NA NA +DTXSID00862685 Css 3compartmentss Human 95% 19.83 mg/L NA NA NA +DTXSID00866067 Css 3compartmentss Human 95% 1.212 mg/L NA NA NA +DTXSID00867110 Css 3compartmentss Human 95% 3.77 mg/L NA NA NA +DTXSID00868985 Css 3compartmentss Human 95% 4.735 mg/L NA NA NA +DTXSID00870104 Css 3compartmentss Human 95% 1.636 mg/L NA NA NA +DTXSID00870220 Css 3compartmentss Human 95% 0.4157 mg/L NA NA NA +DTXSID00872663 Css 3compartmentss Human 95% 142.8 mg/L 119.5 mg/L 1.19497907949791 +DTXSID00873377 Css 3compartmentss Human 95% 0.3113 mg/L NA NA NA +DTXSID00880006 Css 3compartmentss Human 95% 7.622 mg/L NA NA NA +DTXSID00880647 Css 3compartmentss Human 95% 4.271 mg/L NA NA NA +DTXSID00880662 Css 3compartmentss Human 95% 18.05 mg/L NA NA NA +DTXSID00880682 Css 3compartmentss Human 95% 0.2807 mg/L NA NA NA +DTXSID00880743 Css 3compartmentss Human 95% 9.124 mg/L NA NA NA +DTXSID00880763 Css 3compartmentss Human 95% 1.914 mg/L NA NA NA +DTXSID00880849 Css 3compartmentss Human 95% 19.33 mg/L NA NA NA +DTXSID00880884 Css 3compartmentss Human 95% 14.2 mg/L NA NA NA +DTXSID00880900 Css 3compartmentss Human 95% 6.805 mg/L NA NA NA +DTXSID00880905 Css 3compartmentss Human 95% 19.72 mg/L NA NA NA +DTXSID00880920 Css 3compartmentss Human 95% 5.775 mg/L NA NA NA +DTXSID00881210 Css 3compartmentss Human 95% 9.712 mg/L NA NA NA +DTXSID00904978 Css 3compartmentss Human 95% 7.522 mg/L 1.823 mg/L 4.12616566099836 +DTXSID00905081 Css 3compartmentss Human 95% 5.655 mg/L NA NA NA +DTXSID00951523 Css 3compartmentss Human 95% 3.307 mg/L NA NA NA +DTXSID00953320 Css 3compartmentss Human 95% 8.754 mg/L NA NA NA +DTXSID00955107 Css 3compartmentss Human 95% 0.9023 mg/L NA NA NA +DTXSID101017364 Css 3compartmentss Human 95% 0.254 mg/L 1.407 mg/L 0.180525941719972 +DTXSID101021648 Css 3compartmentss Human 95% 2.675 mg/L NA NA NA +DTXSID10110043 Css 3compartmentss Human 95% 0.9776 mg/L NA NA NA +DTXSID101100630 Css 3compartmentss Human 95% 3.131 mg/L NA NA NA +DTXSID101111653 Css 3compartmentss Human 95% 0.7563 mg/L NA NA NA +DTXSID10146483 Css 3compartmentss Human 95% 0.9159 mg/L NA NA NA +DTXSID10150282 Css 3compartmentss Human 95% 2.878 mg/L NA NA NA +DTXSID10152862 Css 3compartmentss Human 95% 9.405 mg/L NA NA NA +DTXSID10158107 Css 3compartmentss Human 95% 4.878 mg/L NA NA NA +DTXSID10161474 Css 3compartmentss Human 95% 0.8279 mg/L NA NA NA +DTXSID10165351 Css 3compartmentss Human 95% 50.26 mg/L NA NA NA +DTXSID10173436 Css 3compartmentss Human 95% 7.012 mg/L NA NA NA +DTXSID10174443 Css 3compartmentss Human 95% 0.8551 mg/L NA NA NA +DTXSID10175096 Css 3compartmentss Human 95% 0.4157 mg/L NA NA NA +DTXSID10180160 Css 3compartmentss Human 95% 3.173 mg/L NA NA NA +DTXSID10189315 Css 3compartmentss Human 95% 4.555 mg/L NA NA NA +DTXSID10191973 Css 3compartmentss Human 95% 1.656 mg/L NA NA NA +DTXSID10193230 Css 3compartmentss Human 95% 8.116 mg/L NA NA NA +DTXSID10198927 Css 3compartmentss Human 95% 0.2774 mg/L 0.2893 mg/L 0.958866228828206 +DTXSID1020015 Css 3compartmentss Human 95% 0.9289 mg/L 1.957 mg/L 0.474655084312724 +DTXSID1020063 Css 3compartmentss Human 95% 0.5946 mg/L 1.337 mg/L 0.444727000747943 +DTXSID1020069 Css 3compartmentss Human 95% 64.99 mg/L 78.02 mg/L 0.832991540630608 +DTXSID1020140 Css 3compartmentss Human 95% 1.224 mg/L 16.23 mg/L 0.0754158964879852 +DTXSID1020142 Css 3compartmentss Human 95% 2.443 mg/L 2.53 mg/L 0.965612648221344 +DTXSID1020144 Css 3compartmentss Human 95% 1.94 mg/L 4.388 mg/L 0.442114858705561 +DTXSID1020146 Css 3compartmentss Human 95% 14.52 mg/L 7.226 mg/L 2.00941046221976 +DTXSID1020190 Css 3compartmentss Human 95% 40.87 mg/L 16.02 mg/L 2.55118601747815 +DTXSID1020221 Css 3compartmentss Human 95% 1.52 mg/L 1.584 mg/L 0.95959595959596 +DTXSID1020223 Css 3compartmentss Human 95% 4.91 mg/L 5.584 mg/L 0.879297994269341 +DTXSID1020275 Css 3compartmentss Human 95% 13.99 mg/L 2.393 mg/L 5.84621813623067 +DTXSID1020308 Css 3compartmentss Human 95% 0.3993 mg/L 1.868 mg/L 0.213758029978587 +DTXSID1020350 Css 3compartmentss Human 95% 0.4504 mg/L 0.4467 mg/L 1.00828296395791 +DTXSID1020352 Css 3compartmentss Human 95% 0.4221 mg/L 14.15 mg/L 0.0298303886925795 +DTXSID1020354 Css 3compartmentss Human 95% 4.856 mg/L 5.748 mg/L 0.844815588030619 +DTXSID1020358 Css 3compartmentss Human 95% 5.025 mg/L 5.726 mg/L 0.877575969263011 +DTXSID1020433 Css 3compartmentss Human 95% 6.522 mg/L 1.001 mg/L 6.51548451548452 +DTXSID1020439 Css 3compartmentss Human 95% 1.149 mg/L 2.467 mg/L 0.465747871909201 +DTXSID10204698 Css 3compartmentss Human 95% 6.227 mg/L NA NA NA +DTXSID1020483 Css 3compartmentss Human 95% 7.647 mg/L 0.05109 mg/L 149.677040516735 +DTXSID1020485 Css 3compartmentss Human 95% 2.633 mg/L 2.693 mg/L 0.977720014853323 +DTXSID1020510 Css 3compartmentss Human 95% 152.9 mg/L 137.2 mg/L 1.11443148688047 +DTXSID1020512 Css 3compartmentss Human 95% 4.29 mg/L 4.819 mg/L 0.89022618800581 +DTXSID1020516 Css 3compartmentss Human 95% 5.107 mg/L 6.62 mg/L 0.771450151057402 +DTXSID1020560 Css 3compartmentss Human 95% 100.9 mg/L 145.2 mg/L 0.694903581267218 +DTXSID1020647 Css 3compartmentss Human 95% 0.3106 mg/L 1.216 mg/L 0.255427631578947 +DTXSID1020697 Css 3compartmentss Human 95% 19.74 mg/L 2.576 mg/L 7.66304347826087 +DTXSID1020699 Css 3compartmentss Human 95% 5.467 mg/L 2.012 mg/L 2.71719681908549 +DTXSID1020728 Css 3compartmentss Human 95% 5.056 mg/L 5.911 mg/L 0.855354423955338 +DTXSID1020770 Css 3compartmentss Human 95% 3655 mg/L NA NA NA +DTXSID1020803 Css 3compartmentss Human 95% 116.1 mg/L 624.5 mg/L 0.185908726981585 +DTXSID1020807 Css 3compartmentss Human 95% 5.144 mg/L 5.23 mg/L 0.983556405353728 +DTXSID1020809 Css 3compartmentss Human 95% 6.545 mg/L 7.793 mg/L 0.83985628127807 +DTXSID1020855 Css 3compartmentss Human 95% 14.03 mg/L 14.65 mg/L 0.957679180887372 +DTXSID1020857 Css 3compartmentss Human 95% 7.614 mg/L 0.9896 mg/L 7.69401778496362 +DTXSID1020859 Css 3compartmentss Human 95% 0.4156 mg/L 2.278 mg/L 0.182440737489025 +DTXSID1020930 Css 3compartmentss Human 95% 0.8556 mg/L 0.9639 mg/L 0.887643946467476 +DTXSID1020932 Css 3compartmentss Human 95% 0.7483 mg/L 0.7551 mg/L 0.990994570255595 +DTXSID1020982 Css 3compartmentss Human 95% 7.556 mg/L 8.78 mg/L 0.860592255125285 +DTXSID1020984 Css 3compartmentss Human 95% 3.17 mg/L 1.707 mg/L 1.85705916813122 +DTXSID1021031 Css 3compartmentss Human 95% 0.05202 mg/L 0.05076 mg/L 1.02482269503546 +DTXSID1021039 Css 3compartmentss Human 95% 0.3816 mg/L 3.483 mg/L 0.109560723514212 +DTXSID1021081 Css 3compartmentss Human 95% 6.577 mg/L 365 mg/L 0.0180191780821918 +DTXSID1021087 Css 3compartmentss Human 95% 27.75 mg/L 31.95 mg/L 0.868544600938967 +DTXSID1021089 Css 3compartmentss Human 95% 1.48 mg/L 23.94 mg/L 0.0618212197159566 +DTXSID10211069 Css 3compartmentss Human 95% 10.09 mg/L NA NA NA +DTXSID1021116 Css 3compartmentss Human 95% 0.5259 mg/L 0.6744 mg/L 0.779804270462633 +DTXSID1021118 Css 3compartmentss Human 95% 2.731 mg/L 5.555 mg/L 0.491629162916292 +DTXSID1021160 Css 3compartmentss Human 95% 9.462 mg/L 9.622 mg/L 0.983371440448971 +DTXSID1021162 Css 3compartmentss Human 95% 6.122 mg/L 1.416 mg/L 4.32344632768362 +DTXSID1021164 Css 3compartmentss Human 95% 1.31 mg/L 1.415 mg/L 0.925795053003534 +DTXSID1021166 Css 3compartmentss Human 95% 5.055 mg/L 3.788 mg/L 1.3344772967265 +DTXSID1021168 Css 3compartmentss Human 95% 18.05 mg/L 19.08 mg/L 0.94601677148847 +DTXSID1021243 Css 3compartmentss Human 95% 1026 mg/L 925.7 mg/L 1.10835043750675 +DTXSID1021247 Css 3compartmentss Human 95% 2.834 mg/L 3.186 mg/L 0.889516635279347 +DTXSID1021299 Css 3compartmentss Human 95% 9455 mg/L 8257 mg/L 1.14508901538089 +DTXSID1021320 Css 3compartmentss Human 95% 9.571 mg/L 0.9488 mg/L 10.087478920742 +DTXSID1021322 Css 3compartmentss Human 95% 1.504 mg/L 1.439 mg/L 1.045170257123 +DTXSID10213609 Css 3compartmentss Human 95% 2.834 mg/L NA NA NA +DTXSID1021372 Css 3compartmentss Human 95% 0.6822 mg/L 0.3693 mg/L 1.84727863525589 +DTXSID1021378 Css 3compartmentss Human 95% 8.741 mg/L 10.35 mg/L 0.844541062801932 +DTXSID1021403 Css 3compartmentss Human 95% 0.9879 mg/L 5.784 mg/L 0.170798755186722 +DTXSID1021405 Css 3compartmentss Human 95% 19.88 mg/L 8.656 mg/L 2.29667282809612 +DTXSID1021455 Css 3compartmentss Human 95% 3.714 mg/L 22.03 mg/L 0.168588288697231 +DTXSID1021530 Css 3compartmentss Human 95% 0.3653 mg/L 4.294 mg/L 0.0850721937587331 +DTXSID1021584 Css 3compartmentss Human 95% 0.3694 mg/L NA NA NA +DTXSID1021586 Css 3compartmentss Human 95% 11.11 mg/L NA NA NA +DTXSID1021615 Css 3compartmentss Human 95% 2.668 mg/L 3.129 mg/L 0.852668584212208 +DTXSID1021617 Css 3compartmentss Human 95% 1.523 mg/L 38.68 mg/L 0.0393743536711479 +DTXSID1021740 Css 3compartmentss Human 95% 0.3558 mg/L 5.785 mg/L 0.0615038893690579 +DTXSID1021744 Css 3compartmentss Human 95% 0.5037 mg/L 11.22 mg/L 0.0448930481283422 +DTXSID1021790 Css 3compartmentss Human 95% 0.6402 mg/L 12.55 mg/L 0.0510119521912351 +DTXSID1021792 Css 3compartmentss Human 95% 0.5237 mg/L 0.8153 mg/L 0.642340242855391 +DTXSID1021798 Css 3compartmentss Human 95% 0.4755 mg/L 0.4753 mg/L 1.00042078687145 +DTXSID1021821 Css 3compartmentss Human 95% 6.833 mg/L 5.319 mg/L 1.28463996991916 +DTXSID1021823 Css 3compartmentss Human 95% 8.241 mg/L 5.706 mg/L 1.44426919032597 +DTXSID1021871 Css 3compartmentss Human 95% 0.7586 mg/L 1.67 mg/L 0.454251497005988 +DTXSID1021877 Css 3compartmentss Human 95% 4.778 mg/L 5.587 mg/L 0.855199570431359 +DTXSID1021904 Css 3compartmentss Human 95% 3.151 mg/L 3.482 mg/L 0.904939689833429 +DTXSID1021952 Css 3compartmentss Human 95% 31.05 mg/L 30.62 mg/L 1.01404310907903 +DTXSID1021956 Css 3compartmentss Human 95% 633.1 mg/L 656.1 mg/L 0.964944368236549 +DTXSID1021958 Css 3compartmentss Human 95% 2.624 mg/L 0.8027 mg/L 3.26896723557992 +DTXSID1022009 Css 3compartmentss Human 95% 0.03765 mg/L 0.01883 mg/L 1.99946893255443 +DTXSID1022051 Css 3compartmentss Human 95% 0.9246 mg/L 1.988 mg/L 0.465090543259557 +DTXSID1022053 Css 3compartmentss Human 95% 1910 mg/L 1992 mg/L 0.958835341365462 +DTXSID1022130 Css 3compartmentss Human 95% 2.959 mg/L NA NA NA +DTXSID1022138 Css 3compartmentss Human 95% 0.3001 mg/L 4.313 mg/L 0.0695803385114769 +DTXSID1022186 Css 3compartmentss Human 95% 0.383 mg/L NA NA NA +DTXSID1022217 Css 3compartmentss Human 95% 0.4376 mg/L 0.01418 mg/L 30.8603667136812 +DTXSID1022265 Css 3compartmentss Human 95% 0.8667 mg/L 1.158 mg/L 0.748445595854922 +DTXSID1022267 Css 3compartmentss Human 95% 0.7965 mg/L 0.8153 mg/L 0.976941003311664 +DTXSID1022392 Css 3compartmentss Human 95% 3.756 mg/L NA NA NA +DTXSID1022394 Css 3compartmentss Human 95% 0.8385 mg/L 0.8213 mg/L 1.02094240837696 +DTXSID1022396 Css 3compartmentss Human 95% 10.34 mg/L 10.95 mg/L 0.944292237442922 +DTXSID1022421 Css 3compartmentss Human 95% 2.912 mg/L 3.904 mg/L 0.745901639344262 +DTXSID1022425 Css 3compartmentss Human 95% 24.22 mg/L 6.828 mg/L 3.54715875805507 +DTXSID1022479 Css 3compartmentss Human 95% 0.9949 mg/L 1.405 mg/L 0.708113879003559 +DTXSID1022556 Css 3compartmentss Human 95% 3.063 mg/L 0.2936 mg/L 10.4325613079019 +DTXSID1022558 Css 3compartmentss Human 95% 3.657 mg/L 5.484 mg/L 0.666849015317287 +DTXSID1022635 Css 3compartmentss Human 95% 6.405 mg/L 5.613 mg/L 1.14110101549973 +DTXSID1022639 Css 3compartmentss Human 95% 0.5557 mg/L NA NA NA +DTXSID1022681 Css 3compartmentss Human 95% 28.9 mg/L 3.103 mg/L 9.31356751530777 +DTXSID1022683 Css 3compartmentss Human 95% 18.07 mg/L 3.074 mg/L 5.87833441769681 +DTXSID1022687 Css 3compartmentss Human 95% 1.468 mg/L 0.1155 mg/L 12.7099567099567 +DTXSID1022714 Css 3compartmentss Human 95% 2.406 mg/L NA NA NA +DTXSID1022718 Css 3compartmentss Human 95% 0.8045 mg/L 0.4406 mg/L 1.82591920108942 +DTXSID1022760 Css 3compartmentss Human 95% 8.844 mg/L 14.93 mg/L 0.592364367046216 +DTXSID1022762 Css 3compartmentss Human 95% 16.01 mg/L 27.21 mg/L 0.588386622565233 +DTXSID1022764 Css 3compartmentss Human 95% 3.777 mg/L 3.007 mg/L 1.25606917193216 +DTXSID1022766 Css 3compartmentss Human 95% 1.177 mg/L 0.07466 mg/L 15.7648004286097 +DTXSID1022768 Css 3compartmentss Human 95% 26.84 mg/L 25.32 mg/L 1.06003159557662 +DTXSID1022843 Css 3compartmentss Human 95% 1.575 mg/L 0.392 mg/L 4.01785714285714 +DTXSID1022845 Css 3compartmentss Human 95% 1.147 mg/L 1.136 mg/L 1.00968309859155 +DTXSID1022847 Css 3compartmentss Human 95% 1.01 mg/L 1.552 mg/L 0.650773195876289 +DTXSID1022893 Css 3compartmentss Human 95% 5.036 mg/L NA NA NA +DTXSID1022897 Css 3compartmentss Human 95% 10.24 mg/L 11.63 mg/L 0.880481513327601 +DTXSID1022922 Css 3compartmentss Human 95% 7.899 mg/L 22.86 mg/L 0.345538057742782 +DTXSID1022924 Css 3compartmentss Human 95% 8.91 mg/L NA NA NA +DTXSID1022974 Css 3compartmentss Human 95% 7.374 mg/L 16.56 mg/L 0.445289855072464 +DTXSID1022978 Css 3compartmentss Human 95% 7.714 mg/L 3.034 mg/L 2.54251812788398 +DTXSID1023021 Css 3compartmentss Human 95% 2.975 mg/L 8.47 mg/L 0.351239669421488 +DTXSID1023027 Css 3compartmentss Human 95% 5.517 mg/L 2.695 mg/L 2.04712430426716 +DTXSID1023029 Css 3compartmentss Human 95% 4.462 mg/L NA NA NA +DTXSID1023071 Css 3compartmentss Human 95% 3.556 mg/L 5.103 mg/L 0.696844993141289 +DTXSID1023077 Css 3compartmentss Human 95% 0.9851 mg/L NA NA NA +DTXSID1023102 Css 3compartmentss Human 95% 0.6046 mg/L 2.949 mg/L 0.205018650389963 +DTXSID1023150 Css 3compartmentss Human 95% 2.614 mg/L 4.692 mg/L 0.557118499573742 +DTXSID1023158 Css 3compartmentss Human 95% 3.117 mg/L 5.669 mg/L 0.549832421943905 +DTXSID1023231 Css 3compartmentss Human 95% 1.509 mg/L 7.219 mg/L 0.209031721845131 +DTXSID1023235 Css 3compartmentss Human 95% 4.21 mg/L 5.588 mg/L 0.753400143163923 +DTXSID1023239 Css 3compartmentss Human 95% 7.341 mg/L 7.61 mg/L 0.964651773981603 +DTXSID1023281 Css 3compartmentss Human 95% 7.655 mg/L 4.467 mg/L 1.7136780837251 +DTXSID1023287 Css 3compartmentss Human 95% 10.35 mg/L 13.25 mg/L 0.781132075471698 +DTXSID1023289 Css 3compartmentss Human 95% 29.83 mg/L NA NA NA +DTXSID1023310 Css 3compartmentss Human 95% 4.493 mg/L 7.966 mg/L 0.564022093899071 +DTXSID1023314 Css 3compartmentss Human 95% 1.423 mg/L 4.119 mg/L 0.345472201990774 +DTXSID1023316 Css 3compartmentss Human 95% 0.5051 mg/L 2.241 mg/L 0.225390450691656 +DTXSID1023318 Css 3compartmentss Human 95% 6.7 mg/L NA NA NA +DTXSID1023362 Css 3compartmentss Human 95% 1.332 mg/L 1.193 mg/L 1.11651299245599 +DTXSID1023364 Css 3compartmentss Human 95% 2.337 mg/L 0.1414 mg/L 16.5275813295615 +DTXSID1023368 Css 3compartmentss Human 95% 30.33 mg/L 1094 mg/L 0.0277239488117002 +DTXSID10233968 Css 3compartmentss Human 95% 10.07 mg/L NA NA NA +DTXSID1023441 Css 3compartmentss Human 95% 3.925 mg/L 3.097 mg/L 1.26735550532774 +DTXSID1023495 Css 3compartmentss Human 95% 0.6647 mg/L 1.427 mg/L 0.465802382620883 +DTXSID1023497 Css 3compartmentss Human 95% 7.839 mg/L 222.8 mg/L 0.0351840215439856 +DTXSID10234975 Css 3compartmentss Human 95% 5.533 mg/L NA NA NA +DTXSID1023524 Css 3compartmentss Human 95% 0.4108 mg/L 0.4139 mg/L 0.99251026818072 +DTXSID1023526 Css 3compartmentss Human 95% 0.1536 mg/L NA NA NA +DTXSID1023572 Css 3compartmentss Human 95% 10.14 mg/L 83.76 mg/L 0.121060171919771 +DTXSID1023576 Css 3compartmentss Human 95% 34.53 mg/L 92.26 mg/L 0.374268371992196 +DTXSID1023603 Css 3compartmentss Human 95% 7.326 mg/L 1.152 mg/L 6.359375 +DTXSID1023605 Css 3compartmentss Human 95% 1.586 mg/L 1.737 mg/L 0.913068508923431 +DTXSID1023607 Css 3compartmentss Human 95% 7.724 mg/L 7.093 mg/L 1.08896094741294 +DTXSID1023609 Css 3compartmentss Human 95% 4.052 mg/L 0.09447 mg/L 42.8919233619138 +DTXSID1023653 Css 3compartmentss Human 95% 18.34 mg/L NA NA NA +DTXSID1023730 Css 3compartmentss Human 95% 8.309 mg/L 5.577 mg/L 1.48986910525372 +DTXSID1023734 Css 3compartmentss Human 95% 7.908 mg/L 8.499 mg/L 0.93046240734204 +DTXSID1023736 Css 3compartmentss Human 95% 1.621 mg/L 1737 mg/L 0.00093321819228555 +DTXSID10237885 Css 3compartmentss Human 95% 3.237 mg/L NA NA NA +DTXSID1023815 Css 3compartmentss Human 95% 6.376 mg/L 7.489 mg/L 0.851382026972894 +DTXSID1023817 Css 3compartmentss Human 95% 2.065 mg/L NA NA NA +DTXSID1023819 Css 3compartmentss Human 95% 5.49 mg/L 1.487 mg/L 3.69199731002017 +DTXSID1023869 Css 3compartmentss Human 95% 38.25 mg/L 39.67 mg/L 0.964204688681623 +DTXSID1023990 Css 3compartmentss Human 95% 10.87 mg/L 11.2 mg/L 0.970535714285714 +DTXSID1023996 Css 3compartmentss Human 95% 6.334 mg/L 2.085 mg/L 3.0378896882494 +DTXSID1023998 Css 3compartmentss Human 95% 14.26 mg/L 5.689 mg/L 2.50659166813148 +DTXSID1024045 Css 3compartmentss Human 95% 6.224 mg/L 6.49 mg/L 0.959013867488444 +DTXSID1024049 Css 3compartmentss Human 95% 207.1 mg/L 211.4 mg/L 0.979659413434248 +DTXSID1024091 Css 3compartmentss Human 95% 0.6633 mg/L 0.4549 mg/L 1.45812266432183 +DTXSID1024097 Css 3compartmentss Human 95% 0.835 mg/L 0.9198 mg/L 0.907806044792346 +DTXSID1024124 Css 3compartmentss Human 95% 5.441 mg/L 6.513 mg/L 0.835406110855213 +DTXSID1024126 Css 3compartmentss Human 95% 1937 mg/L 1940 mg/L 0.998453608247423 +DTXSID1024128 Css 3compartmentss Human 95% 9994 mg/L NA NA NA +DTXSID1024174 Css 3compartmentss Human 95% 3.48 mg/L 3.638 mg/L 0.956569543705333 +DTXSID1024255 Css 3compartmentss Human 95% 12.32 mg/L 8.268 mg/L 1.49008224479923 +DTXSID1024259 Css 3compartmentss Human 95% 15.12 mg/L 14.71 mg/L 1.02787219578518 +DTXSID1024338 Css 3compartmentss Human 95% 1.922 mg/L 2.053 mg/L 0.936190940087677 +DTXSID1024413 Css 3compartmentss Human 95% 0.4374 mg/L 3.786 mg/L 0.115530903328051 +DTXSID1024463 Css 3compartmentss Human 95% 8.195 mg/L 7.549 mg/L 1.0855742482448 +DTXSID1024465 Css 3compartmentss Human 95% 0.351 mg/L 2.927 mg/L 0.119918004783054 +DTXSID1024467 Css 3compartmentss Human 95% 0.7656 mg/L 2.186 mg/L 0.350228728270814 +DTXSID1024598 Css 3compartmentss Human 95% 10.25 mg/L 16.15 mg/L 0.634674922600619 +DTXSID1024621 Css 3compartmentss Human 95% 7.68 mg/L 5.177 mg/L 1.48348464361599 +DTXSID1024625 Css 3compartmentss Human 95% 19.24 mg/L 10.89 mg/L 1.76675849403122 +DTXSID1024629 Css 3compartmentss Human 95% 18.49 mg/L 1.13 mg/L 16.3628318584071 +DTXSID1024702 Css 3compartmentss Human 95% 6.902 mg/L NA NA NA +DTXSID1024831 Css 3compartmentss Human 95% 0.3448 mg/L 8.387 mg/L 0.0411112435912722 +DTXSID1024835 Css 3compartmentss Human 95% 0.7411 mg/L NA NA NA +DTXSID1024837 Css 3compartmentss Human 95% 11.73 mg/L NA NA NA +DTXSID1024881 Css 3compartmentss Human 95% 7.25 mg/L 4.9 mg/L 1.47959183673469 +DTXSID1024885 Css 3compartmentss Human 95% 2.051 mg/L 8.074 mg/L 0.254025266286847 +DTXSID1024916 Css 3compartmentss Human 95% 9.341 mg/L 1.526 mg/L 6.12123197903014 +DTXSID1024918 Css 3compartmentss Human 95% 4.9 mg/L 2.772 mg/L 1.76767676767677 +DTXSID1024966 Css 3compartmentss Human 95% 2.826 mg/L 3.032 mg/L 0.932058047493404 +DTXSID1025013 Css 3compartmentss Human 95% 5.65 mg/L 9.275 mg/L 0.609164420485175 +DTXSID1025017 Css 3compartmentss Human 95% 22.68 mg/L NA NA NA +DTXSID1025063 Css 3compartmentss Human 95% 5.63 mg/L 5.031 mg/L 1.11906181673624 +DTXSID1025065 Css 3compartmentss Human 95% 13.68 mg/L 15.9 mg/L 0.860377358490566 +DTXSID1025148 Css 3compartmentss Human 95% 0.6381 mg/L 1.362 mg/L 0.468502202643172 +DTXSID1025271 Css 3compartmentss Human 95% 0.6329 mg/L 0.6476 mg/L 0.977300802964793 +DTXSID1025279 Css 3compartmentss Human 95% 0.3613 mg/L 3.361 mg/L 0.107497768521273 +DTXSID1025302 Css 3compartmentss Human 95% 20.59 mg/L 6.293 mg/L 3.27188940092166 +DTXSID1025304 Css 3compartmentss Human 95% 0.2445 mg/L 0.09833 mg/L 2.48652496694803 +DTXSID1025431 Css 3compartmentss Human 95% 3.161 mg/L 4.63 mg/L 0.682721382289417 +DTXSID1025433 Css 3compartmentss Human 95% 5.372 mg/L 6.129 mg/L 0.876488823625387 +DTXSID1025437 Css 3compartmentss Human 95% 4.76 mg/L 5.713 mg/L 0.833187467180115 +DTXSID1025485 Css 3compartmentss Human 95% 9.373 mg/L 5.9 mg/L 1.58864406779661 +DTXSID1025512 Css 3compartmentss Human 95% 4.419 mg/L 0.3761 mg/L 11.7495346982186 +DTXSID1025560 Css 3compartmentss Human 95% 3.396 mg/L 2.737 mg/L 1.24077457069784 +DTXSID1025641 Css 3compartmentss Human 95% 1.971 mg/L 19.4 mg/L 0.10159793814433 +DTXSID1025693 Css 3compartmentss Human 95% 0.5146 mg/L 0.03563 mg/L 14.4428852090935 +DTXSID1025722 Css 3compartmentss Human 95% 0.6583 mg/L 5.271 mg/L 0.124890912540315 +DTXSID1025724 Css 3compartmentss Human 95% 0.6799 mg/L 1.591 mg/L 0.427341294783155 +DTXSID1025726 Css 3compartmentss Human 95% 0.7227 mg/L 2.763 mg/L 0.261563517915309 +DTXSID1025770 Css 3compartmentss Human 95% 0.4219 mg/L 0.1669 mg/L 2.52786099460755 +DTXSID1025774 Css 3compartmentss Human 95% 0.7883 mg/L 11.07 mg/L 0.0712104787714544 +DTXSID1025776 Css 3compartmentss Human 95% 0.8277 mg/L 11.62 mg/L 0.0712306368330465 +DTXSID1025805 Css 3compartmentss Human 95% 15.46 mg/L NA NA NA +DTXSID1025807 Css 3compartmentss Human 95% 5.131 mg/L 67.96 mg/L 0.0755002942907593 +DTXSID1025853 Css 3compartmentss Human 95% 7.766 mg/L 9.151 mg/L 0.848650420719047 +DTXSID1025857 Css 3compartmentss Human 95% 1.895 mg/L NA NA NA +DTXSID1025930 Css 3compartmentss Human 95% 2.147 mg/L 36.58 mg/L 0.0586932750136687 +DTXSID1026031 Css 3compartmentss Human 95% 1.301 mg/L 74.8 mg/L 0.0173930481283422 +DTXSID1026033 Css 3compartmentss Human 95% 8.065 mg/L 2.845 mg/L 2.83479789103691 +DTXSID1026035 Css 3compartmentss Human 95% 2.686 mg/L 2.885 mg/L 0.931022530329289 +DTXSID1026081 Css 3compartmentss Human 95% 11.89 mg/L 9.161 mg/L 1.29789324309573 +DTXSID1026112 Css 3compartmentss Human 95% 0.8023 mg/L 0.3438 mg/L 2.33362420011635 +DTXSID1026164 Css 3compartmentss Human 95% 3.224 mg/L 3.332 mg/L 0.967587034813926 +DTXSID1026241 Css 3compartmentss Human 95% 7.531 mg/L 6.669 mg/L 1.12925476083371 +DTXSID1026293 Css 3compartmentss Human 95% 17.28 mg/L 136 mg/L 0.127058823529412 +DTXSID1026457 Css 3compartmentss Human 95% 8.912 mg/L 9.112 mg/L 0.978050921861282 +DTXSID1026536 Css 3compartmentss Human 95% 0.8856 mg/L 8.613 mg/L 0.10282131661442 +DTXSID1026615 Css 3compartmentss Human 95% 7.423 mg/L NA NA NA +DTXSID1026619 Css 3compartmentss Human 95% 2.767 mg/L 4.602 mg/L 0.601260321599305 +DTXSID1026661 Css 3compartmentss Human 95% 0.3457 mg/L NA NA NA +DTXSID1026665 Css 3compartmentss Human 95% 7.267 mg/L 5.579 mg/L 1.30256318336619 +DTXSID1026667 Css 3compartmentss Human 95% 0.4174 mg/L 0.9525 mg/L 0.438215223097113 +DTXSID1026740 Css 3compartmentss Human 95% 1.963 mg/L 0.2414 mg/L 8.13173156586578 +DTXSID1026792 Css 3compartmentss Human 95% 0.2041 mg/L 0.2371 mg/L 0.86081822016027 +DTXSID1026796 Css 3compartmentss Human 95% 0.2162 mg/L 0.03089 mg/L 6.99902881191324 +DTXSID1026879 Css 3compartmentss Human 95% 1.768 mg/L 1.975 mg/L 0.895189873417721 +DTXSID1026904 Css 3compartmentss Human 95% 0.3829 mg/L 0.06996 mg/L 5.47312750142939 +DTXSID1026906 Css 3compartmentss Human 95% 9.485 mg/L NA NA NA +DTXSID1026908 Css 3compartmentss Human 95% 0.3823 mg/L 0.8493 mg/L 0.450135405628164 +DTXSID1026954 Css 3compartmentss Human 95% 0.4871 mg/L 0.3791 mg/L 1.28488525455025 +DTXSID1027134 Css 3compartmentss Human 95% 5.357 mg/L 16 mg/L 0.3348125 +DTXSID1027188 Css 3compartmentss Human 95% 0.2915 mg/L 1.371 mg/L 0.212618526622903 +DTXSID1027219 Css 3compartmentss Human 95% 1.224 mg/L 16.23 mg/L 0.0754158964879852 +DTXSID1027265 Css 3compartmentss Human 95% 6.268 mg/L 3.154 mg/L 1.98731769181991 +DTXSID1027344 Css 3compartmentss Human 95% 1.536 mg/L 2.745 mg/L 0.559562841530055 +DTXSID1027425 Css 3compartmentss Human 95% 0.5718 mg/L 32.49 mg/L 0.0175992613111727 +DTXSID1027427 Css 3compartmentss Human 95% 6.438 mg/L 2.626 mg/L 2.45163747143945 +DTXSID1027429 Css 3compartmentss Human 95% 8.235 mg/L 37.12 mg/L 0.221848060344828 +DTXSID1027479 Css 3compartmentss Human 95% 6.942 mg/L 6.876 mg/L 1.00959860383944 +DTXSID1027500 Css 3compartmentss Human 95% 5.477 mg/L 3.386 mg/L 1.61754282339043 +DTXSID1027502 Css 3compartmentss Human 95% 6.213 mg/L 2.489 mg/L 2.49618320610687 +DTXSID1027504 Css 3compartmentss Human 95% 5.272 mg/L NA NA NA +DTXSID1027506 Css 3compartmentss Human 95% 11.78 mg/L 17.22 mg/L 0.684088269454123 +DTXSID1027508 Css 3compartmentss Human 95% 5.839 mg/L NA NA NA +DTXSID1027550 Css 3compartmentss Human 95% 6.496 mg/L 7.256 mg/L 0.895259095920617 +DTXSID1027556 Css 3compartmentss Human 95% 7.243 mg/L 8.338 mg/L 0.868673542816023 +DTXSID1027558 Css 3compartmentss Human 95% 0.8395 mg/L 3.798 mg/L 0.221037388098999 +DTXSID1027633 Css 3compartmentss Human 95% 0.0187 mg/L 5.2e-08 mg/L 359615.384615385 +DTXSID1027635 Css 3compartmentss Human 95% 43.01 mg/L 44.04 mg/L 0.97661217075386 +DTXSID1027639 Css 3compartmentss Human 95% 8.133 mg/L 5.827 mg/L 1.39574395057491 +DTXSID1027764 Css 3compartmentss Human 95% 3.343 mg/L 15 mg/L 0.222866666666667 +DTXSID1027768 Css 3compartmentss Human 95% 7.207 mg/L 8.257 mg/L 0.872835170158653 +DTXSID1027920 Css 3compartmentss Human 95% 3.417 mg/L 0.2002 mg/L 17.0679320679321 +DTXSID1027970 Css 3compartmentss Human 95% 0.5716 mg/L 9.181 mg/L 0.0622590131793922 +DTXSID1027978 Css 3compartmentss Human 95% 2.591 mg/L 0.8805 mg/L 2.94264622373651 +DTXSID10282052 Css 3compartmentss Human 95% 16.61 mg/L NA NA NA +DTXSID10288059 Css 3compartmentss Human 95% 17.42 mg/L NA NA NA +DTXSID10289223 Css 3compartmentss Human 95% 11.21 mg/L NA NA NA +DTXSID1029120 Css 3compartmentss Human 95% 6.449 mg/L 8.551 mg/L 0.754180797567536 +DTXSID1029122 Css 3compartmentss Human 95% 2.98 mg/L 1.752 mg/L 1.70091324200913 +DTXSID1029128 Css 3compartmentss Human 95% 6.088 mg/L 5.161 mg/L 1.17961635341988 +DTXSID1029201 Css 3compartmentss Human 95% 8.264 mg/L 8.757 mg/L 0.943702181112253 +DTXSID1029207 Css 3compartmentss Human 95% 0.3492 mg/L 2.12 mg/L 0.164716981132075 +DTXSID1029251 Css 3compartmentss Human 95% 5.123 mg/L 8.673 mg/L 0.590683731119567 +DTXSID1029255 Css 3compartmentss Human 95% 0.4465 mg/L 6.958 mg/L 0.0641707387180224 +DTXSID10293820 Css 3compartmentss Human 95% 7.169 mg/L NA NA NA +DTXSID1029629 Css 3compartmentss Human 95% 0.2698 mg/L 5.981 mg/L 0.0451095134592877 +DTXSID1029671 Css 3compartmentss Human 95% 6.373 mg/L 7.415 mg/L 0.859474039109912 +DTXSID1029889 Css 3compartmentss Human 95% 0.8901 mg/L 3.265 mg/L 0.272618683001531 +DTXSID1030317 Css 3compartmentss Human 95% 0.8939 mg/L 4.063 mg/L 0.220009844942161 +DTXSID1030319 Css 3compartmentss Human 95% 1.256 mg/L 6.266 mg/L 0.200446856048516 +DTXSID1030604 Css 3compartmentss Human 95% 7.842 mg/L 7.295 mg/L 1.07498286497601 +DTXSID1030606 Css 3compartmentss Human 95% 5.841 mg/L 3.254 mg/L 1.79502151198525 +DTXSID1031591 Css 3compartmentss Human 95% 6.382 mg/L 7.75 mg/L 0.823483870967742 +DTXSID1031626 Css 3compartmentss Human 95% 1.134 mg/L 1.664 mg/L 0.681490384615385 +DTXSID1032278 Css 3compartmentss Human 95% 0.06182 mg/L 0.06741 mg/L 0.917074618009197 +DTXSID1032303 Css 3compartmentss Human 95% 10.43 mg/L 17.83 mg/L 0.584969153112731 +DTXSID1032309 Css 3compartmentss Human 95% 9.748 mg/L 22.4 mg/L 0.435178571428571 +DTXSID1032355 Css 3compartmentss Human 95% 4.73 mg/L 4.808 mg/L 0.983777038269551 +DTXSID1032359 Css 3compartmentss Human 95% 42.15 mg/L 43.94 mg/L 0.959262630860264 +DTXSID1032482 Css 3compartmentss Human 95% 11.59 mg/L 13.57 mg/L 0.854089904200442 +DTXSID1032484 Css 3compartmentss Human 95% 19.86 mg/L 0.1282 mg/L 154.914196567863 +DTXSID1032488 Css 3compartmentss Human 95% 8.495 mg/L 9.031 mg/L 0.940648876093456 +DTXSID1032511 Css 3compartmentss Human 95% 7.142 mg/L 1.102 mg/L 6.48094373865699 +DTXSID1032513 Css 3compartmentss Human 95% 0.3045 mg/L 0.7407 mg/L 0.41109761036857 +DTXSID1032519 Css 3compartmentss Human 95% 0.2108 mg/L 0.194 mg/L 1.08659793814433 +DTXSID1032569 Css 3compartmentss Human 95% 1.044 mg/L 1.037 mg/L 1.00675024108004 +DTXSID1032640 Css 3compartmentss Human 95% 63.93 mg/L 162.4 mg/L 0.39365763546798 +DTXSID1032642 Css 3compartmentss Human 95% 5.085 mg/L 7.705 mg/L 0.659961064243997 +DTXSID1032648 Css 3compartmentss Human 95% 9.571 mg/L 0.9488 mg/L 10.087478920742 +DTXSID1032690 Css 3compartmentss Human 95% 11.43 mg/L 14.81 mg/L 0.771775827143822 +DTXSID1033161 Css 3compartmentss Human 95% 6.338 mg/L 0.1128 mg/L 56.1879432624114 +DTXSID1033163 Css 3compartmentss Human 95% 20.86 mg/L 57.48 mg/L 0.362908837856646 +DTXSID1033371 Css 3compartmentss Human 95% 4.688 mg/L 5.747 mg/L 0.815729946058813 +DTXSID1033402 Css 3compartmentss Human 95% 2.626 mg/L 119.9 mg/L 0.0219015846538782 +DTXSID1033539 Css 3compartmentss Human 95% 4.288 mg/L 13.42 mg/L 0.319523099850969 +DTXSID1033664 Css 3compartmentss Human 95% 8.608 mg/L 8.808 mg/L 0.977293369663942 +DTXSID10338220 Css 3compartmentss Human 95% 7.285 mg/L NA NA NA +DTXSID1034181 Css 3compartmentss Human 95% 2.973 mg/L 3.47 mg/L 0.856772334293948 +DTXSID1034187 Css 3compartmentss Human 95% 3390 mg/L 3646 mg/L 0.929786066922655 +DTXSID1034210 Css 3compartmentss Human 95% 37.02 mg/L 28.99 mg/L 1.27699206622973 +DTXSID1034212 Css 3compartmentss Human 95% 233 mg/L 88.04 mg/L 2.64652430713312 +DTXSID1034214 Css 3compartmentss Human 95% 9.743 mg/L 0.1511 mg/L 64.4804765056254 +DTXSID1034260 Css 3compartmentss Human 95% 3.101 mg/L 3.593 mg/L 0.863067074867799 +DTXSID1034266 Css 3compartmentss Human 95% 5.893 mg/L 4.694 mg/L 1.25543246697912 +DTXSID1034501 Css 3compartmentss Human 95% 11.5 mg/L 2.766 mg/L 4.15762834417932 +DTXSID1034503 Css 3compartmentss Human 95% 7.136 mg/L 2.429 mg/L 2.93783449979415 +DTXSID1034634 Css 3compartmentss Human 95% 7.729 mg/L 8.145 mg/L 0.948925721301412 +DTXSID1034769 Css 3compartmentss Human 95% 2.206 mg/L 9.575 mg/L 0.230391644908616 +DTXSID1034844 Css 3compartmentss Human 95% 10.66 mg/L 1.678 mg/L 6.35280095351609 +DTXSID1034925 Css 3compartmentss Human 95% 6.39 mg/L NA NA NA +DTXSID1034929 Css 3compartmentss Human 95% 3.699 mg/L 3.19 mg/L 1.15956112852665 +DTXSID1034973 Css 3compartmentss Human 95% 398.7 mg/L 413.7 mg/L 0.963741841914431 +DTXSID1035288 Css 3compartmentss Human 95% 9.332 mg/L 2.53 mg/L 3.68853754940712 +DTXSID1035783 Css 3compartmentss Human 95% 19.65 mg/L 4.752 mg/L 4.13510101010101 +DTXSID10359814 Css 3compartmentss Human 95% 3.95 mg/L NA NA NA +DTXSID1036541 Css 3compartmentss Human 95% 7.73 mg/L 4.551 mg/L 1.69852779608877 +DTXSID1036545 Css 3compartmentss Human 95% 10.92 mg/L 26.78 mg/L 0.407766990291262 +DTXSID1037197 Css 3compartmentss Human 95% 0.1185 mg/L 0.1198 mg/L 0.98914858096828 +DTXSID1037224 Css 3compartmentss Human 95% 14.5 mg/L 0.2914 mg/L 49.7597803706246 +DTXSID1037272 Css 3compartmentss Human 95% 0.002274 mg/L 0.005082 mg/L 0.447461629279811 +DTXSID1037515 Css 3compartmentss Human 95% 4.052 mg/L 0.7395 mg/L 5.47937795807978 +DTXSID1037565 Css 3compartmentss Human 95% 15.23 mg/L 3.276 mg/L 4.64896214896215 +DTXSID1037567 Css 3compartmentss Human 95% 1.975 mg/L 2.804 mg/L 0.70435092724679 +DTXSID1037696 Css 3compartmentss Human 95% 0.2378 mg/L 0.1319 mg/L 1.80288097043215 +DTXSID1037806 Css 3compartmentss Human 95% 3.145 mg/L 2.78 mg/L 1.13129496402878 +DTXSID1038321 Css 3compartmentss Human 95% 385.1 mg/L 398.2 mg/L 0.967101958814666 +DTXSID1038666 Css 3compartmentss Human 95% 1.61 mg/L 5.17 mg/L 0.311411992263056 +DTXSID1038743 Css 3compartmentss Human 95% 1.069 mg/L 4.135 mg/L 0.258524788391778 +DTXSID1038799 Css 3compartmentss Human 95% 0.3832 mg/L NA NA NA +DTXSID1038822 Css 3compartmentss Human 95% 11.33 mg/L 1.183 mg/L 9.57734573119189 +DTXSID1038824 Css 3compartmentss Human 95% 4.805 mg/L 5.296 mg/L 0.907288519637462 +DTXSID1038876 Css 3compartmentss Human 95% 24.37 mg/L 2.203 mg/L 11.0621879255561 +DTXSID1038878 Css 3compartmentss Human 95% 13.47 mg/L NA NA NA +DTXSID10393157 Css 3compartmentss Human 95% 5.521 mg/L NA NA NA +DTXSID1040114 Css 3compartmentss Human 95% 8.222 mg/L 1.829 mg/L 4.49535265172225 +DTXSID1040164 Css 3compartmentss Human 95% 5.051 mg/L 5.619 mg/L 0.898914397579641 +DTXSID1040243 Css 3compartmentss Human 95% 2.983 mg/L NA NA NA +DTXSID1040245 Css 3compartmentss Human 95% 4.102 mg/L 8.647 mg/L 0.474384179484214 +DTXSID1040295 Css 3compartmentss Human 95% 6.798 mg/L 0.316 mg/L 21.5126582278481 +DTXSID1040320 Css 3compartmentss Human 95% 16.56 mg/L 1.497 mg/L 11.062124248497 +DTXSID1040324 Css 3compartmentss Human 95% 0.9585 mg/L 0.3639 mg/L 2.63396537510305 +DTXSID1040326 Css 3compartmentss Human 95% 6.729 mg/L 5.842 mg/L 1.15183156453269 +DTXSID1040372 Css 3compartmentss Human 95% 87.6 mg/L 70.14 mg/L 1.24893071000855 +DTXSID1040459 Css 3compartmentss Human 95% 1.501 mg/L 4.593 mg/L 0.326801654691922 +DTXSID1040586 Css 3compartmentss Human 95% 1.192 mg/L NA NA NA +DTXSID1040617 Css 3compartmentss Human 95% 1.009 mg/L 0.9187 mg/L 1.09829106345924 +DTXSID1040619 Css 3compartmentss Human 95% 13.46 mg/L 195.3 mg/L 0.0689196108550947 +DTXSID1040661 Css 3compartmentss Human 95% 5.588 mg/L 150.8 mg/L 0.0370557029177719 +DTXSID1040667 Css 3compartmentss Human 95% 0.5002 mg/L 0.5225 mg/L 0.957320574162679 +DTXSID1040740 Css 3compartmentss Human 95% 6.334 mg/L 2.429 mg/L 2.60765747221079 +DTXSID1040742 Css 3compartmentss Human 95% 0.8236 mg/L 1.573 mg/L 0.523585505403687 +DTXSID1040792 Css 3compartmentss Human 95% 4.58 mg/L 3.082 mg/L 1.48604802076574 +DTXSID1040794 Css 3compartmentss Human 95% 4.248 mg/L 6.761 mg/L 0.628309421683183 +DTXSID1041051 Css 3compartmentss Human 95% 4.359 mg/L NA NA NA +DTXSID1041057 Css 3compartmentss Human 95% 8.95 mg/L NA NA NA +DTXSID1041132 Css 3compartmentss Human 95% 0.8557 mg/L 6.27 mg/L 0.136475279106858 +DTXSID1041188 Css 3compartmentss Human 95% 1.671 mg/L 3.173 mg/L 0.526630948629058 +DTXSID1041217 Css 3compartmentss Human 95% 11.22 mg/L 11.81 mg/L 0.95004233700254 +DTXSID1041261 Css 3compartmentss Human 95% 0.3337 mg/L 1.161 mg/L 0.287424633936262 +DTXSID1041263 Css 3compartmentss Human 95% 3.238 mg/L 2.726 mg/L 1.18782098312546 +DTXSID1041267 Css 3compartmentss Human 95% 0.2959 mg/L 4.885 mg/L 0.0605731832139202 +DTXSID1041346 Css 3compartmentss Human 95% 2.283 mg/L 2.513 mg/L 0.908475925189017 +DTXSID1041421 Css 3compartmentss Human 95% 0.674 mg/L 0.394 mg/L 1.71065989847716 +DTXSID1041423 Css 3compartmentss Human 95% 7.837 mg/L 2.405 mg/L 3.25862785862786 +DTXSID1041506 Css 3compartmentss Human 95% 10.25 mg/L 3.684 mg/L 2.78230184581976 +DTXSID1041550 Css 3compartmentss Human 95% 4.271 mg/L 5.096 mg/L 0.838108320251177 +DTXSID10415505 Css 3compartmentss Human 95% 0.5714 mg/L NA NA NA +DTXSID1041639 Css 3compartmentss Human 95% 0.6777 mg/L 9.561 mg/L 0.0708817069344211 +DTXSID1041681 Css 3compartmentss Human 95% 32.53 mg/L 503.9 mg/L 0.064556459615003 +DTXSID1041689 Css 3compartmentss Human 95% 4.676 mg/L 49.26 mg/L 0.0949248883475437 +DTXSID1041847 Css 3compartmentss Human 95% 1.596 mg/L 3.206 mg/L 0.497816593886463 +DTXSID1041897 Css 3compartmentss Human 95% 5.736 mg/L 0.229 mg/L 25.0480349344978 +DTXSID1041920 Css 3compartmentss Human 95% 0.8756 mg/L 4.287 mg/L 0.204245393048752 +DTXSID1041970 Css 3compartmentss Human 95% 1.456 mg/L 5.271 mg/L 0.276228419654714 +DTXSID1041978 Css 3compartmentss Human 95% 19.3 mg/L 14.67 mg/L 1.31561008861622 +DTXSID1042077 Css 3compartmentss Human 95% 14.15 mg/L 14.99 mg/L 0.943962641761174 +DTXSID1042154 Css 3compartmentss Human 95% 10.49 mg/L 10.85 mg/L 0.966820276497696 +DTXSID1042281 Css 3compartmentss Human 95% 9.286 mg/L 10.09 mg/L 0.920317145688801 +DTXSID1042285 Css 3compartmentss Human 95% 8.663 mg/L 0.2524 mg/L 34.3225039619651 +DTXSID1042360 Css 3compartmentss Human 95% 4.419 mg/L 1.621 mg/L 2.72609500308452 +DTXSID1042364 Css 3compartmentss Human 95% 1.771 mg/L 264.1 mg/L 0.00670579326012874 +DTXSID1042441 Css 3compartmentss Human 95% 16.13 mg/L 3.5 mg/L 4.60857142857143 +DTXSID1042443 Css 3compartmentss Human 95% 2.4 mg/L 1.721 mg/L 1.39453805926787 +DTXSID1042445 Css 3compartmentss Human 95% 2.443 mg/L 1.008 mg/L 2.42361111111111 +DTXSID1042570 Css 3compartmentss Human 95% 5.831 mg/L 2.126 mg/L 2.74270931326435 +DTXSID1042574 Css 3compartmentss Human 95% 1.747 mg/L 1.578 mg/L 1.10709759188847 +DTXSID1043835 Css 3compartmentss Human 95% 2.422 mg/L 2.385 mg/L 1.01551362683438 +DTXSID1043839 Css 3compartmentss Human 95% 1.872 mg/L 3.764 mg/L 0.497343251859724 +DTXSID1043881 Css 3compartmentss Human 95% 1.397 mg/L 2.294 mg/L 0.608979947689625 +DTXSID1043910 Css 3compartmentss Human 95% 1.654 mg/L 0.5038 mg/L 3.28304882890036 +DTXSID1044196 Css 3compartmentss Human 95% 3.489 mg/L 7.773 mg/L 0.448861443458124 +DTXSID1044198 Css 3compartmentss Human 95% 0.3704 mg/L 9.34 mg/L 0.0396573875802998 +DTXSID1044221 Css 3compartmentss Human 95% 1.469 mg/L 0.04493 mg/L 32.6953038059203 +DTXSID1044223 Css 3compartmentss Human 95% 10.54 mg/L 25.45 mg/L 0.414145383104126 +DTXSID1044227 Css 3compartmentss Human 95% 7.109 mg/L 0.6964 mg/L 10.2082136703044 +DTXSID1044356 Css 3compartmentss Human 95% 7.675 mg/L 0.3348 mg/L 22.9241338112306 +DTXSID1044431 Css 3compartmentss Human 95% 5.6 mg/L 5.252 mg/L 1.06626047220107 +DTXSID1044433 Css 3compartmentss Human 95% 7.643 mg/L 7.884 mg/L 0.969431760527651 +DTXSID1044435 Css 3compartmentss Human 95% 0.8738 mg/L 0.095 mg/L 9.19789473684211 +DTXSID1044437 Css 3compartmentss Human 95% 4.681 mg/L 7.765 mg/L 0.602833226014166 +DTXSID1044439 Css 3compartmentss Human 95% 6.935 mg/L 6.562 mg/L 1.05684242608961 +DTXSID1044481 Css 3compartmentss Human 95% 12.74 mg/L 1.305 mg/L 9.76245210727969 +DTXSID1044485 Css 3compartmentss Human 95% 7.287 mg/L 7.133 mg/L 1.0215897939156 +DTXSID1044489 Css 3compartmentss Human 95% 5.676 mg/L 6.658 mg/L 0.852508260738961 +DTXSID1044514 Css 3compartmentss Human 95% 9.395 mg/L 2.284 mg/L 4.11339754816112 +DTXSID1044560 Css 3compartmentss Human 95% 0.3844 mg/L 4.767 mg/L 0.0806377176421229 +DTXSID1044562 Css 3compartmentss Human 95% 34.38 mg/L NA NA NA +DTXSID1044564 Css 3compartmentss Human 95% 89.95 mg/L 92.72 mg/L 0.970125107851596 +DTXSID1044568 Css 3compartmentss Human 95% 5.459 mg/L 3.032 mg/L 1.8004617414248 +DTXSID1044645 Css 3compartmentss Human 95% 0.978 mg/L 0.7532 mg/L 1.29845990440786 +DTXSID1044647 Css 3compartmentss Human 95% 0.4632 mg/L NA NA NA +DTXSID1044691 Css 3compartmentss Human 95% 21.76 mg/L 19.06 mg/L 1.14165792235047 +DTXSID1044693 Css 3compartmentss Human 95% 1.228 mg/L 16.23 mg/L 0.0756623536660505 +DTXSID1044699 Css 3compartmentss Human 95% 5.293 mg/L NA NA NA +DTXSID1044720 Css 3compartmentss Human 95% 0.2447 mg/L 2.132 mg/L 0.114774859287054 +DTXSID1044722 Css 3compartmentss Human 95% 5.082 mg/L 1.334 mg/L 3.8095952023988 +DTXSID1044724 Css 3compartmentss Human 95% 6.1 mg/L 8.126 mg/L 0.750676839773566 +DTXSID1044728 Css 3compartmentss Human 95% 1.304 mg/L NA NA NA +DTXSID1044770 Css 3compartmentss Human 95% 1.694 mg/L 0.1252 mg/L 13.5303514376997 +DTXSID1044774 Css 3compartmentss Human 95% 9.77 mg/L 4.014 mg/L 2.43398106626806 +DTXSID1044776 Css 3compartmentss Human 95% 0.3521 mg/L 4.759 mg/L 0.0739861315402395 +DTXSID1044801 Css 3compartmentss Human 95% 3.847 mg/L 4.363 mg/L 0.881732752693101 +DTXSID1044805 Css 3compartmentss Human 95% 0.5309 mg/L 0.5069 mg/L 1.04734661668968 +DTXSID1044807 Css 3compartmentss Human 95% 1.438 mg/L 0.1013 mg/L 14.1954590325765 +DTXSID1044809 Css 3compartmentss Human 95% 1.113 mg/L 1.107 mg/L 1.00542005420054 +DTXSID1044851 Css 3compartmentss Human 95% 0.5886 mg/L 9.288 mg/L 0.0633720930232558 +DTXSID1044853 Css 3compartmentss Human 95% 4.212 mg/L 4.81 mg/L 0.875675675675676 +DTXSID1044859 Css 3compartmentss Human 95% 30.04 mg/L 58.08 mg/L 0.517217630853995 +DTXSID1044930 Css 3compartmentss Human 95% 0.8408 mg/L 2.332 mg/L 0.360548885077187 +DTXSID1044932 Css 3compartmentss Human 95% 1.123 mg/L 7.255 mg/L 0.154789800137836 +DTXSID1044934 Css 3compartmentss Human 95% 5.489 mg/L 1.593 mg/L 3.44569993722536 +DTXSID1044936 Css 3compartmentss Human 95% 10.16 mg/L NA NA NA +DTXSID1044938 Css 3compartmentss Human 95% 3.236 mg/L 3.25 mg/L 0.995692307692308 +DTXSID1044980 Css 3compartmentss Human 95% 7.721 mg/L 0.7673 mg/L 10.0625570181155 +DTXSID1044982 Css 3compartmentss Human 95% 0.6106 mg/L 3.371 mg/L 0.181133194897657 +DTXSID1044986 Css 3compartmentss Human 95% 0.3656 mg/L 6.555 mg/L 0.0557742181540809 +DTXSID1045033 Css 3compartmentss Human 95% 775.6 mg/L 1397 mg/L 0.555189692197566 +DTXSID1045081 Css 3compartmentss Human 95% 7.501 mg/L 1.631 mg/L 4.59901900674433 +DTXSID1045083 Css 3compartmentss Human 95% 4.526 mg/L 5.545 mg/L 0.816230838593327 +DTXSID1045085 Css 3compartmentss Human 95% 6.64 mg/L 5.683 mg/L 1.16839697342953 +DTXSID1045089 Css 3compartmentss Human 95% 17.39 mg/L 17.91 mg/L 0.970965940815187 +DTXSID1045110 Css 3compartmentss Human 95% 15.51 mg/L 43.11 mg/L 0.359777313848295 +DTXSID1045112 Css 3compartmentss Human 95% 8.844 mg/L 0.1597 mg/L 55.3788353162179 +DTXSID1045114 Css 3compartmentss Human 95% 2.362 mg/L 10.16 mg/L 0.23248031496063 +DTXSID1045116 Css 3compartmentss Human 95% 2.845 mg/L 3.354 mg/L 0.848240906380441 +DTXSID1045118 Css 3compartmentss Human 95% 1647 mg/L 1622 mg/L 1.0154130702836 +DTXSID1045160 Css 3compartmentss Human 95% 1.147 mg/L 1.286 mg/L 0.891912908242613 +DTXSID1045162 Css 3compartmentss Human 95% 1.485 mg/L 0.4396 mg/L 3.37807097361238 +DTXSID1045164 Css 3compartmentss Human 95% 1.388 mg/L 56.47 mg/L 0.0245794227023198 +DTXSID1045166 Css 3compartmentss Human 95% 1.633 mg/L 1.587 mg/L 1.02898550724638 +DTXSID1045168 Css 3compartmentss Human 95% 1.08 mg/L 25.85 mg/L 0.041779497098646 +DTXSID1045245 Css 3compartmentss Human 95% 1.707 mg/L 3.649 mg/L 0.467799397095095 +DTXSID1045291 Css 3compartmentss Human 95% 9.682 mg/L 128.7 mg/L 0.0752292152292152 +DTXSID1045293 Css 3compartmentss Human 95% 0.3775 mg/L 0.8736 mg/L 0.432119963369963 +DTXSID1045320 Css 3compartmentss Human 95% 0.8676 mg/L 2.085 mg/L 0.416115107913669 +DTXSID1045322 Css 3compartmentss Human 95% 7.48 mg/L 0.177 mg/L 42.2598870056497 +DTXSID1045324 Css 3compartmentss Human 95% 3.708 mg/L 1.442 mg/L 2.57142857142857 +DTXSID1045328 Css 3compartmentss Human 95% 0.7476 mg/L 0.4802 mg/L 1.55685131195335 +DTXSID1045370 Css 3compartmentss Human 95% 7.063 mg/L 0.4103 mg/L 17.2142334876919 +DTXSID1045372 Css 3compartmentss Human 95% 2.823 mg/L 1.268 mg/L 2.22634069400631 +DTXSID1045376 Css 3compartmentss Human 95% 5.797 mg/L 2.464 mg/L 2.35267857142857 +DTXSID1045405 Css 3compartmentss Human 95% 6.951 mg/L 7.35 mg/L 0.945714285714286 +DTXSID1045409 Css 3compartmentss Human 95% 13.76 mg/L NA NA NA +DTXSID1045453 Css 3compartmentss Human 95% 0.9756 mg/L 0.4022 mg/L 2.425658876181 +DTXSID1045459 Css 3compartmentss Human 95% 0.4624 mg/L 0.2203 mg/L 2.098955969133 +DTXSID1045530 Css 3compartmentss Human 95% 7.436 mg/L 1.126 mg/L 6.60390763765542 +DTXSID1045534 Css 3compartmentss Human 95% 12.04 mg/L 0.5706 mg/L 21.1005958640028 +DTXSID1045536 Css 3compartmentss Human 95% 7.836 mg/L 11.5 mg/L 0.681391304347826 +DTXSID1045538 Css 3compartmentss Human 95% 0.7693 mg/L 0.3637 mg/L 2.11520483915315 +DTXSID1045580 Css 3compartmentss Human 95% 6.351 mg/L 0.1752 mg/L 36.25 +DTXSID1045582 Css 3compartmentss Human 95% 12.92 mg/L 50.83 mg/L 0.254180602006689 +DTXSID1045584 Css 3compartmentss Human 95% 6.011 mg/L 957.4 mg/L 0.00627846250261124 +DTXSID1045586 Css 3compartmentss Human 95% 0.9625 mg/L 22.77 mg/L 0.0422705314009662 +DTXSID1045588 Css 3compartmentss Human 95% 5.36 mg/L 0.5444 mg/L 9.84570168993387 +DTXSID1045611 Css 3compartmentss Human 95% 1.563 mg/L 6.053 mg/L 0.258219064926483 +DTXSID1045615 Css 3compartmentss Human 95% 1.338 mg/L 1.046 mg/L 1.2791586998088 +DTXSID1045619 Css 3compartmentss Human 95% 0.9929 mg/L 0.746 mg/L 1.33096514745308 +DTXSID1045661 Css 3compartmentss Human 95% 0.6206 mg/L 1.232 mg/L 0.503733766233766 +DTXSID1045663 Css 3compartmentss Human 95% 1.03 mg/L 0.2477 mg/L 4.15825595478401 +DTXSID1045665 Css 3compartmentss Human 95% 19.48 mg/L 111.9 mg/L 0.17408400357462 +DTXSID1045669 Css 3compartmentss Human 95% 18.93 mg/L 5072 mg/L 0.00373225552050473 +DTXSID1045740 Css 3compartmentss Human 95% 3.487 mg/L 5.834 mg/L 0.597703119643469 +DTXSID1045742 Css 3compartmentss Human 95% 19.04 mg/L 434.1 mg/L 0.0438608615526376 +DTXSID1045744 Css 3compartmentss Human 95% 2.572 mg/L 6.172 mg/L 0.416720674011666 +DTXSID1045746 Css 3compartmentss Human 95% 1.361 mg/L 26.55 mg/L 0.0512617702448211 +DTXSID1045748 Css 3compartmentss Human 95% 0.7085 mg/L 2.677 mg/L 0.264661935001868 +DTXSID1045790 Css 3compartmentss Human 95% 0.3987 mg/L 1.697 mg/L 0.234944018856806 +DTXSID1045792 Css 3compartmentss Human 95% 5.837 mg/L 5.872 mg/L 0.994039509536785 +DTXSID1045794 Css 3compartmentss Human 95% 0.8394 mg/L 1.337 mg/L 0.627823485415108 +DTXSID1045796 Css 3compartmentss Human 95% 0.5893 mg/L NA NA NA +DTXSID1045798 Css 3compartmentss Human 95% 1.537 mg/L 0.9974 mg/L 1.54100661720473 +DTXSID1045871 Css 3compartmentss Human 95% 285.4 mg/L 639.4 mg/L 0.446355958711292 +DTXSID1045873 Css 3compartmentss Human 95% 7.378 mg/L 8.753 mg/L 0.842911001942191 +DTXSID1045877 Css 3compartmentss Human 95% 5.084 mg/L 5.584 mg/L 0.910458452722063 +DTXSID1045879 Css 3compartmentss Human 95% 7.012 mg/L 4.186 mg/L 1.67510750119446 +DTXSID1045902 Css 3compartmentss Human 95% 4.673 mg/L 7.731 mg/L 0.604449618419351 +DTXSID1045904 Css 3compartmentss Human 95% 3.195 mg/L 0.3902 mg/L 8.1881086622245 +DTXSID1045906 Css 3compartmentss Human 95% 0.5681 mg/L 1.818 mg/L 0.312486248624863 +DTXSID1045950 Css 3compartmentss Human 95% 6.378 mg/L 2.115 mg/L 3.01560283687943 +DTXSID1045952 Css 3compartmentss Human 95% 1.19 mg/L 4.038 mg/L 0.29470034670629 +DTXSID1045954 Css 3compartmentss Human 95% 6.54 mg/L 0.3652 mg/L 17.907995618839 +DTXSID1045956 Css 3compartmentss Human 95% 12 mg/L 93.06 mg/L 0.128949065119278 +DTXSID1045958 Css 3compartmentss Human 95% 4.512 mg/L 1.633 mg/L 2.7630128597673 +DTXSID1046003 Css 3compartmentss Human 95% 1.419 mg/L 4.482 mg/L 0.316599732262383 +DTXSID1046007 Css 3compartmentss Human 95% 0.2609 mg/L 0.2905 mg/L 0.898106712564544 +DTXSID1046051 Css 3compartmentss Human 95% 5.093 mg/L 5.575 mg/L 0.913542600896861 +DTXSID10460510 Css 3compartmentss Human 95% 17.09 mg/L NA NA NA +DTXSID1046055 Css 3compartmentss Human 95% 14.4 mg/L 0.641 mg/L 22.4648985959438 +DTXSID1046059 Css 3compartmentss Human 95% 2.511 mg/L 5.34 mg/L 0.470224719101124 +DTXSID1046130 Css 3compartmentss Human 95% 0.3581 mg/L 0.5079 mg/L 0.705060051191179 +DTXSID1046132 Css 3compartmentss Human 95% 6.503 mg/L 7.682 mg/L 0.84652434261911 +DTXSID1046134 Css 3compartmentss Human 95% 31.44 mg/L 112.2 mg/L 0.280213903743316 +DTXSID1046136 Css 3compartmentss Human 95% 2.773 mg/L 29.68 mg/L 0.0934299191374663 +DTXSID1046138 Css 3compartmentss Human 95% 3.244 mg/L 68.63 mg/L 0.0472679586186799 +DTXSID1046180 Css 3compartmentss Human 95% 17.69 mg/L 2.821 mg/L 6.2708259482453 +DTXSID1046182 Css 3compartmentss Human 95% 1.09 mg/L 0.2744 mg/L 3.97230320699709 +DTXSID1046186 Css 3compartmentss Human 95% 1.372 mg/L 0.9063 mg/L 1.51384751186141 +DTXSID1046188 Css 3compartmentss Human 95% 2.764 mg/L 0.3848 mg/L 7.18295218295218 +DTXSID1046211 Css 3compartmentss Human 95% 8.024 mg/L 146.7 mg/L 0.0546966598500341 +DTXSID1046213 Css 3compartmentss Human 95% 11.92 mg/L 0.1159 mg/L 102.847282139776 +DTXSID1046215 Css 3compartmentss Human 95% 5.493 mg/L 4.532 mg/L 1.21204766107679 +DTXSID1046217 Css 3compartmentss Human 95% 4.839 mg/L 17.96 mg/L 0.269432071269488 +DTXSID1046261 Css 3compartmentss Human 95% 5.229 mg/L 5.731 mg/L 0.912406211830396 +DTXSID1046265 Css 3compartmentss Human 95% 420.2 mg/L 434.5 mg/L 0.967088607594937 +DTXSID1046267 Css 3compartmentss Human 95% 6.102 mg/L 2.973 mg/L 2.05247225025227 +DTXSID1046269 Css 3compartmentss Human 95% 0.595 mg/L 0.3495 mg/L 1.70243204577969 +DTXSID1046342 Css 3compartmentss Human 95% 22.02 mg/L 36.94 mg/L 0.596101786681104 +DTXSID1046344 Css 3compartmentss Human 95% 1512 mg/L 1823 mg/L 0.829402084476138 +DTXSID1046346 Css 3compartmentss Human 95% 4.968 mg/L 5.532 mg/L 0.898047722342733 +DTXSID1046348 Css 3compartmentss Human 95% 4.351 mg/L 5.067 mg/L 0.858693507006118 +DTXSID1046390 Css 3compartmentss Human 95% 1.715 mg/L 2.885 mg/L 0.594454072790295 +DTXSID1046392 Css 3compartmentss Human 95% 0.3407 mg/L 2.877 mg/L 0.118421967327077 +DTXSID1046394 Css 3compartmentss Human 95% 3.087 mg/L 43.21 mg/L 0.0714417958805832 +DTXSID1046398 Css 3compartmentss Human 95% 0.3687 mg/L 1.195 mg/L 0.308535564853556 +DTXSID1046421 Css 3compartmentss Human 95% 7.801 mg/L 7.963 mg/L 0.979655908577169 +DTXSID1046423 Css 3compartmentss Human 95% 3.7 mg/L 6.587 mg/L 0.561712463944132 +DTXSID1046425 Css 3compartmentss Human 95% 4.491 mg/L 0.8989 mg/L 4.99610635220825 +DTXSID1046427 Css 3compartmentss Human 95% 3.145 mg/L 1.848 mg/L 1.70183982683983 +DTXSID1046429 Css 3compartmentss Human 95% 18.4 mg/L 0.9087 mg/L 20.2487069439859 +DTXSID1046471 Css 3compartmentss Human 95% 0.8457 mg/L 0.5681 mg/L 1.48864636507657 +DTXSID1046475 Css 3compartmentss Human 95% 1.49 mg/L 0.09932 mg/L 15.0020136931132 +DTXSID1046477 Css 3compartmentss Human 95% 9.981 mg/L 19.59 mg/L 0.509494640122511 +DTXSID1046479 Css 3compartmentss Human 95% 3.055 mg/L 16.28 mg/L 0.187653562653563 +DTXSID1046500 Css 3compartmentss Human 95% 4.689 mg/L 20.03 mg/L 0.234098851722416 +DTXSID1046502 Css 3compartmentss Human 95% 0.4396 mg/L 1.82 mg/L 0.241538461538462 +DTXSID1046504 Css 3compartmentss Human 95% 0.413 mg/L 1.268 mg/L 0.325709779179811 +DTXSID1046506 Css 3compartmentss Human 95% 1.605 mg/L 2.198 mg/L 0.730209281164695 +DTXSID1046508 Css 3compartmentss Human 95% 4.232 mg/L 2.099 mg/L 2.0161981896141 +DTXSID1046550 Css 3compartmentss Human 95% 1.24 mg/L 4.005 mg/L 0.309612983770287 +DTXSID1046552 Css 3compartmentss Human 95% 0.02239 mg/L 0.03024 mg/L 0.740410052910053 +DTXSID1046556 Css 3compartmentss Human 95% 59.46 mg/L 6.047 mg/L 9.83297502893997 +DTXSID1046558 Css 3compartmentss Human 95% 2.051 mg/L 2.925 mg/L 0.701196581196581 +DTXSID1046631 Css 3compartmentss Human 95% 2.179 mg/L 1.891 mg/L 1.15230037017451 +DTXSID1046633 Css 3compartmentss Human 95% 2.388 mg/L 0.8985 mg/L 2.65776293823038 +DTXSID1046637 Css 3compartmentss Human 95% 6.251 mg/L 63.17 mg/L 0.0989552002532848 +DTXSID1046639 Css 3compartmentss Human 95% 0.4852 mg/L 1.361 mg/L 0.356502571638501 +DTXSID1046681 Css 3compartmentss Human 95% 14.23 mg/L 5.992 mg/L 2.37483311081442 +DTXSID1046683 Css 3compartmentss Human 95% 11.39 mg/L 245 mg/L 0.0464897959183673 +DTXSID1046685 Css 3compartmentss Human 95% 10.98 mg/L 92.69 mg/L 0.11845938073147 +DTXSID1046687 Css 3compartmentss Human 95% 4.18 mg/L 0.8925 mg/L 4.68347338935574 +DTXSID1046689 Css 3compartmentss Human 95% 0.8631 mg/L 0.2458 mg/L 3.51139137510171 +DTXSID1046710 Css 3compartmentss Human 95% 6.299 mg/L 0.2172 mg/L 29.0009208103131 +DTXSID1046712 Css 3compartmentss Human 95% 4.566 mg/L 8.998 mg/L 0.507446099133141 +DTXSID1046714 Css 3compartmentss Human 95% 6.574 mg/L 0.9933 mg/L 6.61834289741267 +DTXSID1046716 Css 3compartmentss Human 95% 25.59 mg/L 173.7 mg/L 0.147322970639033 +DTXSID1046760 Css 3compartmentss Human 95% 0.9698 mg/L 0.4013 mg/L 2.41664590082233 +DTXSID1046764 Css 3compartmentss Human 95% 0.2944 mg/L 0.696 mg/L 0.422988505747126 +DTXSID1046766 Css 3compartmentss Human 95% 0.4005 mg/L 2.044 mg/L 0.195939334637965 +DTXSID1046768 Css 3compartmentss Human 95% 601.5 mg/L 679.8 mg/L 0.884819064430715 +DTXSID1046841 Css 3compartmentss Human 95% 4.9 mg/L 2.161 mg/L 2.2674687644609 +DTXSID1046843 Css 3compartmentss Human 95% 21.39 mg/L 30.87 mg/L 0.69290573372206 +DTXSID1046845 Css 3compartmentss Human 95% 0.1348 mg/L 3.762 mg/L 0.0358320042530569 +DTXSID1046847 Css 3compartmentss Human 95% 0.4776 mg/L 4.289 mg/L 0.111354628118443 +DTXSID1046849 Css 3compartmentss Human 95% 1.598 mg/L 0.3478 mg/L 4.59459459459459 +DTXSID1046891 Css 3compartmentss Human 95% 0.5998 mg/L 9.921 mg/L 0.0604576151597621 +DTXSID1046895 Css 3compartmentss Human 95% 5.044 mg/L 5.552 mg/L 0.90850144092219 +DTXSID1046926 Css 3compartmentss Human 95% 0.01983 mg/L 0.03312 mg/L 0.598731884057971 +DTXSID1046970 Css 3compartmentss Human 95% 3.164 mg/L 3.422 mg/L 0.924605493863238 +DTXSID1046974 Css 3compartmentss Human 95% 0.7273 mg/L 0.6508 mg/L 1.11754763368162 +DTXSID1046976 Css 3compartmentss Human 95% 0.8102 mg/L 8.413 mg/L 0.0963033400689409 +DTXSID10469987 Css 3compartmentss Human 95% 29.69 mg/L NA NA NA +DTXSID1047071 Css 3compartmentss Human 95% 0.5669 mg/L 1.688 mg/L 0.335841232227488 +DTXSID1047075 Css 3compartmentss Human 95% 0.3085 mg/L 1.662 mg/L 0.185619735258724 +DTXSID1047106 Css 3compartmentss Human 95% 1.535 mg/L 14.95 mg/L 0.102675585284281 +DTXSID1047150 Css 3compartmentss Human 95% 0.928 mg/L 39.55 mg/L 0.0234639696586599 +DTXSID1047158 Css 3compartmentss Human 95% 0.4998 mg/L 9.463 mg/L 0.0528162316390151 +DTXSID1047239 Css 3compartmentss Human 95% 13.53 mg/L 4.442 mg/L 3.04592525889239 +DTXSID1047281 Css 3compartmentss Human 95% 11.04 mg/L 5.039 mg/L 2.19091089501885 +DTXSID1047283 Css 3compartmentss Human 95% 7.927 mg/L 3.071 mg/L 2.58124389449691 +DTXSID1047285 Css 3compartmentss Human 95% 0.6114 mg/L 0.742 mg/L 0.823989218328841 +DTXSID1047287 Css 3compartmentss Human 95% 3.155 mg/L 44.34 mg/L 0.0711547135769057 +DTXSID1047289 Css 3compartmentss Human 95% 1.236 mg/L 1.656 mg/L 0.746376811594203 +DTXSID1047310 Css 3compartmentss Human 95% 19.56 mg/L 96.74 mg/L 0.202191440975811 +DTXSID1047312 Css 3compartmentss Human 95% 1.854 mg/L 2.934 mg/L 0.631901840490798 +DTXSID1047316 Css 3compartmentss Human 95% 5.945 mg/L 3.743 mg/L 1.58829815655891 +DTXSID1047318 Css 3compartmentss Human 95% 4.712 mg/L 60.74 mg/L 0.0775765558116562 +DTXSID1047360 Css 3compartmentss Human 95% 4.515 mg/L 0.855 mg/L 5.28070175438596 +DTXSID1047362 Css 3compartmentss Human 95% 0.5611 mg/L 3.133 mg/L 0.179093520587297 +DTXSID1047366 Css 3compartmentss Human 95% 17.55 mg/L 21.8 mg/L 0.805045871559633 +DTXSID1047368 Css 3compartmentss Human 95% 4.055 mg/L 0.3037 mg/L 13.3519920974646 +DTXSID1047443 Css 3compartmentss Human 95% 0.3775 mg/L 0.2681 mg/L 1.40805669526296 +DTXSID1047447 Css 3compartmentss Human 95% 0.3836 mg/L 0.08742 mg/L 4.38801189659117 +DTXSID1047491 Css 3compartmentss Human 95% 1.01 mg/L 1.385 mg/L 0.729241877256318 +DTXSID1047493 Css 3compartmentss Human 95% 9.159 mg/L 2.928 mg/L 3.1280737704918 +DTXSID1047520 Css 3compartmentss Human 95% 3.75 mg/L NA NA NA +DTXSID1047524 Css 3compartmentss Human 95% 3 mg/L 5.51 mg/L 0.544464609800363 +DTXSID1047528 Css 3compartmentss Human 95% 20.29 mg/L 42.09 mg/L 0.482062247564742 +DTXSID1047570 Css 3compartmentss Human 95% 0.9491 mg/L 2.311 mg/L 0.41068801384682 +DTXSID1047601 Css 3compartmentss Human 95% 0.4818 mg/L 1.631 mg/L 0.29540159411404 +DTXSID1047603 Css 3compartmentss Human 95% 2.346 mg/L NA NA NA +DTXSID1047605 Css 3compartmentss Human 95% 18.12 mg/L 11.01 mg/L 1.64577656675749 +DTXSID1047607 Css 3compartmentss Human 95% 3.42 mg/L NA NA NA +DTXSID1047609 Css 3compartmentss Human 95% 0.367 mg/L 8.504 mg/L 0.0431561618062088 +DTXSID1047780 Css 3compartmentss Human 95% 0.3599 mg/L 0.3793 mg/L 0.948853150540469 +DTXSID1047782 Css 3compartmentss Human 95% 0.3907 mg/L 0.3881 mg/L 1.00669930430301 +DTXSID1047784 Css 3compartmentss Human 95% 3.059 mg/L 2.256 mg/L 1.35593971631206 +DTXSID1047786 Css 3compartmentss Human 95% 2.98 mg/L 0.7269 mg/L 4.09960104553584 +DTXSID1047788 Css 3compartmentss Human 95% 0.5641 mg/L 1.115 mg/L 0.505919282511211 +DTXSID1047811 Css 3compartmentss Human 95% 1.152 mg/L 4.253 mg/L 0.270867622854456 +DTXSID1047813 Css 3compartmentss Human 95% 0.176 mg/L 0.07402 mg/L 2.37773574709538 +DTXSID1047815 Css 3compartmentss Human 95% 0.324 mg/L 0.1102 mg/L 2.94010889292196 +DTXSID1047817 Css 3compartmentss Human 95% 1.174 mg/L 7.718 mg/L 0.152111946100026 +DTXSID1047819 Css 3compartmentss Human 95% 10.79 mg/L 2.695 mg/L 4.00371057513915 +DTXSID1047869 Css 3compartmentss Human 95% 2.483 mg/L 0.003941 mg/L 630.043136259833 +DTXSID1048122 Css 3compartmentss Human 95% 3.608 mg/L 4.079 mg/L 0.884530522186811 +DTXSID1048170 Css 3compartmentss Human 95% 18.59 mg/L 46.27 mg/L 0.401772206613356 +DTXSID1048172 Css 3compartmentss Human 95% 0.7767 mg/L 3.742 mg/L 0.207562800641368 +DTXSID1048174 Css 3compartmentss Human 95% 19.06 mg/L 20.08 mg/L 0.949203187250996 +DTXSID1048176 Css 3compartmentss Human 95% 0.6654 mg/L NA NA NA +DTXSID1048178 Css 3compartmentss Human 95% 7.775 mg/L 351.8 mg/L 0.0221006253553155 +DTXSID1048201 Css 3compartmentss Human 95% 1.646 mg/L 2.624 mg/L 0.627286585365854 +DTXSID1048203 Css 3compartmentss Human 95% 10.2 mg/L 1.976 mg/L 5.16194331983806 +DTXSID1048207 Css 3compartmentss Human 95% 2.278 mg/L 27.57 mg/L 0.0826260428001451 +DTXSID1048257 Css 3compartmentss Human 95% 123.1 mg/L NA NA NA +DTXSID1048259 Css 3compartmentss Human 95% 6.677 mg/L 7.424 mg/L 0.899380387931034 +DTXSID1048384 Css 3compartmentss Human 95% 42.67 mg/L 47.09 mg/L 0.906137184115523 +DTXSID1048542 Css 3compartmentss Human 95% 3.051 mg/L NA NA NA +DTXSID1048548 Css 3compartmentss Human 95% 8.304 mg/L NA NA NA +DTXSID1048590 Css 3compartmentss Human 95% 0.5567 mg/L 0.556 mg/L 1.00125899280576 +DTXSID1048592 Css 3compartmentss Human 95% 1.502 mg/L 6.064 mg/L 0.247691292875989 +DTXSID1048594 Css 3compartmentss Human 95% 5.889 mg/L 8.31 mg/L 0.708664259927798 +DTXSID1048596 Css 3compartmentss Human 95% 135.1 mg/L 70.98 mg/L 1.90335305719921 +DTXSID1048598 Css 3compartmentss Human 95% 6.769 mg/L 4.14 mg/L 1.63502415458937 +DTXSID1048621 Css 3compartmentss Human 95% 0.1847 mg/L 0.2177 mg/L 0.848415250344511 +DTXSID1048625 Css 3compartmentss Human 95% 12.77 mg/L 47.14 mg/L 0.270895205770047 +DTXSID1048627 Css 3compartmentss Human 95% 40.9 mg/L 44.19 mg/L 0.925548766689296 +DTXSID1048629 Css 3compartmentss Human 95% 0.3347 mg/L 14.2 mg/L 0.0235704225352113 +DTXSID1048671 Css 3compartmentss Human 95% 5.038 mg/L 4.991 mg/L 1.00941695051092 +DTXSID1048675 Css 3compartmentss Human 95% 5.012 mg/L 5.933 mg/L 0.844766559919097 +DTXSID1048677 Css 3compartmentss Human 95% 4.355 mg/L 1.26 mg/L 3.45634920634921 +DTXSID1048679 Css 3compartmentss Human 95% 10.61 mg/L 18.31 mg/L 0.579464773347897 +DTXSID1048700 Css 3compartmentss Human 95% 1.959 mg/L 0.4739 mg/L 4.1337834986284 +DTXSID1048704 Css 3compartmentss Human 95% 5.209 mg/L 5.667 mg/L 0.919181224633845 +DTXSID1048706 Css 3compartmentss Human 95% 5.374 mg/L 5.977 mg/L 0.899113267525514 +DTXSID1048708 Css 3compartmentss Human 95% 2.725 mg/L 18.87 mg/L 0.14440911499735 +DTXSID1048750 Css 3compartmentss Human 95% 4.24 mg/L 0.5398 mg/L 7.85476102260096 +DTXSID1048756 Css 3compartmentss Human 95% 1.557 mg/L 2.642 mg/L 0.589326267978804 +DTXSID1048758 Css 3compartmentss Human 95% 1.409 mg/L 2.555 mg/L 0.55146771037182 +DTXSID1048831 Css 3compartmentss Human 95% 3.5 mg/L 3.529 mg/L 0.991782374610371 +DTXSID1048833 Css 3compartmentss Human 95% 1.058 mg/L 2.736 mg/L 0.386695906432749 +DTXSID1048835 Css 3compartmentss Human 95% 5.842 mg/L 8.365 mg/L 0.698386132695756 +DTXSID1048837 Css 3compartmentss Human 95% 0.4227 mg/L 0.5227 mg/L 0.808685670556725 +DTXSID1048839 Css 3compartmentss Human 95% 54.6 mg/L 5.098 mg/L 10.7100823852491 +DTXSID1048881 Css 3compartmentss Human 95% 0.4022 mg/L 0.08216 mg/L 4.89532619279455 +DTXSID1048883 Css 3compartmentss Human 95% 0.4022 mg/L 0.06732 mg/L 5.97445038621509 +DTXSID1048885 Css 3compartmentss Human 95% 0.2612 mg/L 0.02434 mg/L 10.7313064913722 +DTXSID1048887 Css 3compartmentss Human 95% 5.721 mg/L 0.03987 mg/L 143.491346877351 +DTXSID1048889 Css 3compartmentss Human 95% 0.3096 mg/L 0.02779 mg/L 11.1406980928392 +DTXSID1048910 Css 3compartmentss Human 95% 0.297 mg/L 0.8046 mg/L 0.369127516778523 +DTXSID1048912 Css 3compartmentss Human 95% 1.561 mg/L 4.053 mg/L 0.385146804835924 +DTXSID1048914 Css 3compartmentss Human 95% 0.9195 mg/L 0.5678 mg/L 1.61940824233885 +DTXSID1048916 Css 3compartmentss Human 95% 1.477 mg/L 1.583 mg/L 0.933038534428301 +DTXSID1048918 Css 3compartmentss Human 95% 1.665 mg/L 0.7579 mg/L 2.19685974402956 +DTXSID1048960 Css 3compartmentss Human 95% 3.853 mg/L 6.878 mg/L 0.560191916254725 +DTXSID1048962 Css 3compartmentss Human 95% 5.485 mg/L 6.569 mg/L 0.834982493530218 +DTXSID1048964 Css 3compartmentss Human 95% 9.495 mg/L 7.397 mg/L 1.28362849803975 +DTXSID1048968 Css 3compartmentss Human 95% 0.5663 mg/L 0.3737 mg/L 1.51538667380252 +DTXSID1049011 Css 3compartmentss Human 95% 0.2484 mg/L NA NA NA +DTXSID1049015 Css 3compartmentss Human 95% 0.6683 mg/L 18.96 mg/L 0.0352478902953587 +DTXSID1049017 Css 3compartmentss Human 95% 0.3298 mg/L 0.05926 mg/L 5.56530543368208 +DTXSID1049019 Css 3compartmentss Human 95% 6.739 mg/L 4.241 mg/L 1.58901202546569 +DTXSID1049061 Css 3compartmentss Human 95% 3.145 mg/L 5.75 mg/L 0.54695652173913 +DTXSID1049063 Css 3compartmentss Human 95% 0.9389 mg/L 1.829 mg/L 0.513340623291416 +DTXSID1049065 Css 3compartmentss Human 95% 1.77 mg/L 0.9387 mg/L 1.88558644934484 +DTXSID1049067 Css 3compartmentss Human 95% 1.99 mg/L 5.689 mg/L 0.349797855510635 +DTXSID1049069 Css 3compartmentss Human 95% 12.54 mg/L 14.6 mg/L 0.858904109589041 +DTXSID1049221 Css 3compartmentss Human 95% 3.519 mg/L 6.033 mg/L 0.583291894579811 +DTXSID1049223 Css 3compartmentss Human 95% 3.4 mg/L 7.569 mg/L 0.449200687012815 +DTXSID1049225 Css 3compartmentss Human 95% 1.586 mg/L 0.2848 mg/L 5.5688202247191 +DTXSID1049271 Css 3compartmentss Human 95% 16.65 mg/L 16.61 mg/L 1.00240818783865 +DTXSID1049273 Css 3compartmentss Human 95% 11.96 mg/L 16.87 mg/L 0.708950800237107 +DTXSID1049277 Css 3compartmentss Human 95% 16.3 mg/L 2.122 mg/L 7.68143261074458 +DTXSID1049306 Css 3compartmentss Human 95% 4.484 mg/L 7.71 mg/L 0.581582360570687 +DTXSID1049308 Css 3compartmentss Human 95% 7.473 mg/L 3.202 mg/L 2.33385384134916 +DTXSID1049354 Css 3compartmentss Human 95% 9.928 mg/L 290.3 mg/L 0.0341991043747847 +DTXSID1049431 Css 3compartmentss Human 95% 7.46 mg/L 16.71 mg/L 0.446439257929384 +DTXSID1049433 Css 3compartmentss Human 95% 1.157 mg/L 2.646 mg/L 0.437263794406652 +DTXSID1051690 Css 3compartmentss Human 95% 0.5282 mg/L 0.5101 mg/L 1.03548323858067 +DTXSID1051852 Css 3compartmentss Human 95% 5.485 mg/L NA NA NA +DTXSID1051856 Css 3compartmentss Human 95% 4.425 mg/L 3.195 mg/L 1.3849765258216 +DTXSID1051933 Css 3compartmentss Human 95% 0.9699 mg/L NA NA NA +DTXSID1051939 Css 3compartmentss Human 95% 3.549 mg/L 3.133 mg/L 1.13278008298755 +DTXSID1051981 Css 3compartmentss Human 95% 1.746 mg/L NA NA NA +DTXSID1052119 Css 3compartmentss Human 95% 8.024 mg/L NA NA NA +DTXSID1052290 Css 3compartmentss Human 95% 4.386 mg/L NA NA NA +DTXSID1052294 Css 3compartmentss Human 95% 0.6405 mg/L 0.1359 mg/L 4.71302428256071 +DTXSID1052298 Css 3compartmentss Human 95% 1.909 mg/L 1.978 mg/L 0.965116279069767 +DTXSID1052329 Css 3compartmentss Human 95% 32.59 mg/L NA NA NA +DTXSID1052581 Css 3compartmentss Human 95% 1.869 mg/L NA NA NA +DTXSID1052585 Css 3compartmentss Human 95% 6.217 mg/L NA NA NA +DTXSID1052589 Css 3compartmentss Human 95% 1.45 mg/L NA NA NA +DTXSID1052660 Css 3compartmentss Human 95% 3.417 mg/L NA NA NA +DTXSID1052668 Css 3compartmentss Human 95% 1.983 mg/L NA NA NA +DTXSID1052741 Css 3compartmentss Human 95% 7.267 mg/L NA NA NA +DTXSID1057610 Css 3compartmentss Human 95% 14.79 mg/L 18.7 mg/L 0.790909090909091 +DTXSID1057612 Css 3compartmentss Human 95% 1.328 mg/L 4.172 mg/L 0.318312559923298 +DTXSID1057614 Css 3compartmentss Human 95% 6.699 mg/L 0.1183 mg/L 56.6272189349112 +DTXSID1057616 Css 3compartmentss Human 95% 6.972 mg/L 1.715 mg/L 4.06530612244898 +DTXSID1057618 Css 3compartmentss Human 95% 0.4243 mg/L 10.89 mg/L 0.0389623507805326 +DTXSID1057660 Css 3compartmentss Human 95% 2.577 mg/L 7.574 mg/L 0.340242936361236 +DTXSID1057662 Css 3compartmentss Human 95% 0.5874 mg/L 0.458 mg/L 1.2825327510917 +DTXSID1057664 Css 3compartmentss Human 95% 3.397 mg/L 110.1 mg/L 0.0308537693006358 +DTXSID1057666 Css 3compartmentss Human 95% 0.7118 mg/L 0.3193 mg/L 2.22925148762919 +DTXSID1057668 Css 3compartmentss Human 95% 4.251 mg/L 7.87 mg/L 0.540152477763659 +DTXSID1057741 Css 3compartmentss Human 95% 0.68 mg/L 6.389 mg/L 0.10643293160119 +DTXSID1057743 Css 3compartmentss Human 95% 1.748 mg/L 9.293 mg/L 0.188098568815237 +DTXSID1057745 Css 3compartmentss Human 95% 17.76 mg/L 4.912 mg/L 3.61563517915309 +DTXSID1057747 Css 3compartmentss Human 95% 12.27 mg/L 11.04 mg/L 1.11141304347826 +DTXSID1057749 Css 3compartmentss Human 95% 0.8025 mg/L 9.346 mg/L 0.085865610956559 +DTXSID1057791 Css 3compartmentss Human 95% 7.478 mg/L 16.25 mg/L 0.460184615384615 +DTXSID1057793 Css 3compartmentss Human 95% 0.711 mg/L 1.26 mg/L 0.564285714285714 +DTXSID1057795 Css 3compartmentss Human 95% 7.842 mg/L 0.2189 mg/L 35.8245774326176 +DTXSID1057797 Css 3compartmentss Human 95% 2.462 mg/L 15.48 mg/L 0.159043927648579 +DTXSID1057799 Css 3compartmentss Human 95% 0.5267 mg/L 2.422 mg/L 0.217464905037159 +DTXSID1057820 Css 3compartmentss Human 95% 2.41 mg/L 0.1706 mg/L 14.126611957796 +DTXSID1057822 Css 3compartmentss Human 95% 61.5 mg/L 79.19 mg/L 0.776613208738477 +DTXSID1057824 Css 3compartmentss Human 95% 6.234 mg/L 3.207 mg/L 1.94387277829747 +DTXSID1057826 Css 3compartmentss Human 95% 1.46 mg/L 9.918 mg/L 0.147207098205283 +DTXSID1057828 Css 3compartmentss Human 95% 6.903 mg/L 10.42 mg/L 0.662476007677543 +DTXSID10586183 Css 3compartmentss Human 95% 4.721 mg/L NA NA NA +DTXSID1058688 Css 3compartmentss Human 95% 7.75 mg/L NA NA NA +DTXSID1059074 Css 3compartmentss Human 95% 17.17 mg/L NA NA NA +DTXSID1059311 Css 3compartmentss Human 95% 7.206 mg/L NA NA NA +DTXSID1060429 Css 3compartmentss Human 95% 0.4667 mg/L NA NA NA +DTXSID1060556 Css 3compartmentss Human 95% 2.563 mg/L NA NA NA +DTXSID1060687 Css 3compartmentss Human 95% 15.95 mg/L NA NA NA +DTXSID1061025 Css 3compartmentss Human 95% 0.4378 mg/L NA NA NA +DTXSID10623421 Css 3compartmentss Human 95% 0.7849 mg/L NA NA NA +DTXSID1074755 Css 3compartmentss Human 95% 19.54 mg/L NA NA NA +DTXSID10858791 Css 3compartmentss Human 95% 7.034 mg/L NA NA NA +DTXSID10858817 Css 3compartmentss Human 95% 1.384 mg/L 0.1022 mg/L 13.5420743639922 +DTXSID10859960 Css 3compartmentss Human 95% 0.3025 mg/L 2.655 mg/L 0.113935969868173 +DTXSID10862919 Css 3compartmentss Human 95% 7.265 mg/L NA NA NA +DTXSID10863345 Css 3compartmentss Human 95% 4.643 mg/L NA NA NA +DTXSID10866755 Css 3compartmentss Human 95% 1.027 mg/L NA NA NA +DTXSID10867747 Css 3compartmentss Human 95% 2.108 mg/L NA NA NA +DTXSID10868613 Css 3compartmentss Human 95% 14.27 mg/L NA NA NA +DTXSID10869029 Css 3compartmentss Human 95% 0.7386 mg/L NA NA NA +DTXSID10869549 Css 3compartmentss Human 95% 0.8703 mg/L NA NA NA +DTXSID10869988 Css 3compartmentss Human 95% 10.65 mg/L NA NA NA +DTXSID10870170 Css 3compartmentss Human 95% 2.387 mg/L NA NA NA +DTXSID10870312 Css 3compartmentss Human 95% 1.63 mg/L NA NA NA +DTXSID10870938 Css 3compartmentss Human 95% 2.108 mg/L NA NA NA +DTXSID10873202 Css 3compartmentss Human 95% 83.65 mg/L NA NA NA +DTXSID10873222 Css 3compartmentss Human 95% 4.497 mg/L NA NA NA +DTXSID10873363 Css 3compartmentss Human 95% 0.5987 mg/L NA NA NA +DTXSID10873368 Css 3compartmentss Human 95% 74.35 mg/L NA NA NA +DTXSID10879360 Css 3compartmentss Human 95% 7.063 mg/L NA NA NA +DTXSID10880638 Css 3compartmentss Human 95% 1.378 mg/L NA NA NA +DTXSID10880698 Css 3compartmentss Human 95% 7.694 mg/L NA NA NA +DTXSID10880714 Css 3compartmentss Human 95% 13.3 mg/L NA NA NA +DTXSID10880759 Css 3compartmentss Human 95% 1.017 mg/L NA NA NA +DTXSID10880895 Css 3compartmentss Human 95% 11.56 mg/L NA NA NA +DTXSID10880916 Css 3compartmentss Human 95% 4.033 mg/L NA NA NA +DTXSID10881206 Css 3compartmentss Human 95% 14.58 mg/L NA NA NA +DTXSID10958907 Css 3compartmentss Human 95% 0.6891 mg/L NA NA NA +DTXSID201009336 Css 3compartmentss Human 95% 19.31 mg/L NA NA NA +DTXSID201009398 Css 3compartmentss Human 95% 8.241 mg/L NA NA NA +DTXSID201015892 Css 3compartmentss Human 95% 4.691 mg/L NA NA NA +DTXSID201025948 Css 3compartmentss Human 95% 4.494 mg/L NA NA NA +DTXSID201026091 Css 3compartmentss Human 95% 59.85 mg/L NA NA NA +DTXSID201114062 Css 3compartmentss Human 95% 1.772 mg/L NA NA NA +DTXSID20150238 Css 3compartmentss Human 95% 44.75 mg/L NA NA NA +DTXSID20152499 Css 3compartmentss Human 95% 101.5 mg/L NA NA NA +DTXSID20155309 Css 3compartmentss Human 95% 21.75 mg/L NA NA NA +DTXSID20163045 Css 3compartmentss Human 95% 3.46 mg/L NA NA NA +DTXSID20163782 Css 3compartmentss Human 95% 1.36 mg/L NA NA NA +DTXSID20165786 Css 3compartmentss Human 95% 0.2848 mg/L NA NA NA +DTXSID20165928 Css 3compartmentss Human 95% 6.26 mg/L NA NA NA +DTXSID20170956 Css 3compartmentss Human 95% 33.91 mg/L NA NA NA +DTXSID20173260 Css 3compartmentss Human 95% 19.8 mg/L NA NA NA +DTXSID20179106 Css 3compartmentss Human 95% 21.43 mg/L NA NA NA +DTXSID20179702 Css 3compartmentss Human 95% 7.68 mg/L NA NA NA +DTXSID20182594 Css 3compartmentss Human 95% 0.3574 mg/L NA NA NA +DTXSID20190199 Css 3compartmentss Human 95% 20.48 mg/L NA NA NA +DTXSID20191469 Css 3compartmentss Human 95% 0.6254 mg/L NA NA NA +DTXSID20192693 Css 3compartmentss Human 95% 3.188 mg/L NA NA NA +DTXSID2020006 Css 3compartmentss Human 95% 1.044 mg/L 1.411 mg/L 0.739900779588944 +DTXSID2020054 Css 3compartmentss Human 95% 0.4413 mg/L 6.266 mg/L 0.070427705075008 +DTXSID2020137 Css 3compartmentss Human 95% 1.95 mg/L 1.961 mg/L 0.994390617032126 +DTXSID2020139 Css 3compartmentss Human 95% 97.23 mg/L 105.3 mg/L 0.923361823361823 +DTXSID2020189 Css 3compartmentss Human 95% 8.625 mg/L 28.31 mg/L 0.304662663369834 +DTXSID2020210 Css 3compartmentss Human 95% 8.109 mg/L 1.799 mg/L 4.50750416898277 +DTXSID2020212 Css 3compartmentss Human 95% 7.298 mg/L 6.532 mg/L 1.11726883037355 +DTXSID2020260 Css 3compartmentss Human 95% 5.697 mg/L 111.1 mg/L 0.0512781278127813 +DTXSID2020262 Css 3compartmentss Human 95% 10.3 mg/L 97.92 mg/L 0.105187908496732 +DTXSID2020266 Css 3compartmentss Human 95% 14.28 mg/L NA NA NA +DTXSID2020268 Css 3compartmentss Human 95% 44.06 mg/L 239 mg/L 0.184351464435146 +DTXSID20202746 Css 3compartmentss Human 95% 1.151 mg/L NA NA NA +DTXSID20202988 Css 3compartmentss Human 95% 0.479 mg/L NA NA NA +DTXSID2020341 Css 3compartmentss Human 95% 0.1758 mg/L 0.2083 mg/L 0.843975036005761 +DTXSID2020345 Css 3compartmentss Human 95% 6.539 mg/L 7.282 mg/L 0.897967591321066 +DTXSID2020347 Css 3compartmentss Human 95% 15.44 mg/L 15.92 mg/L 0.969849246231156 +DTXSID2020349 Css 3compartmentss Human 95% 0.4142 mg/L 0.1339 mg/L 3.09335324869305 +DTXSID2020391 Css 3compartmentss Human 95% 10.66 mg/L 12.05 mg/L 0.884647302904564 +DTXSID2020399 Css 3compartmentss Human 95% 3.091 mg/L 2.201 mg/L 1.40436165379373 +DTXSID2020420 Css 3compartmentss Human 95% 10.05 mg/L 12.53 mg/L 0.802075019952115 +DTXSID2020424 Css 3compartmentss Human 95% 6.838 mg/L 6.167 mg/L 1.10880492946327 +DTXSID2020426 Css 3compartmentss Human 95% 285.1 mg/L 24.33 mg/L 11.718043567612 +DTXSID2020428 Css 3compartmentss Human 95% 6.365 mg/L 7.163 mg/L 0.888594164456233 +DTXSID2020470 Css 3compartmentss Human 95% 1.175 mg/L 0.05683 mg/L 20.6756994545135 +DTXSID2020474 Css 3compartmentss Human 95% 0.6046 mg/L 1.097 mg/L 0.551139471285324 +DTXSID2020478 Css 3compartmentss Human 95% 4.64 mg/L 7.273 mg/L 0.637976075897154 +DTXSID2020501 Css 3compartmentss Human 95% 5.922 mg/L 15.42 mg/L 0.384046692607004 +DTXSID2020505 Css 3compartmentss Human 95% 2.893 mg/L 3.35 mg/L 0.863582089552239 +DTXSID2020509 Css 3compartmentss Human 95% 5.827 mg/L 5.015 mg/L 1.16191425722832 +DTXSID2020557 Css 3compartmentss Human 95% 61.7 mg/L 238.9 mg/L 0.25826705734617 +DTXSID2020634 Css 3compartmentss Human 95% 4.279 mg/L 5.94 mg/L 0.72037037037037 +DTXSID2020636 Css 3compartmentss Human 95% 63.93 mg/L 214.2 mg/L 0.298459383753501 +DTXSID2020680 Css 3compartmentss Human 95% 7.567 mg/L 0.9499 mg/L 7.96610169491525 +DTXSID2020684 Css 3compartmentss Human 95% 102.2 mg/L 114.7 mg/L 0.891020052310375 +DTXSID2020686 Css 3compartmentss Human 95% 211 mg/L 265.2 mg/L 0.795625942684766 +DTXSID2020713 Css 3compartmentss Human 95% 1.974 mg/L 3.049 mg/L 0.647425385372253 +DTXSID2020717 Css 3compartmentss Human 95% 8.702 mg/L 1.683 mg/L 5.17052881758764 +DTXSID2020767 Css 3compartmentss Human 95% 1.674 mg/L NA NA NA +DTXSID2020846 Css 3compartmentss Human 95% 5.842 mg/L 6.675 mg/L 0.875205992509363 +DTXSID2020890 Css 3compartmentss Human 95% 6.52 mg/L 7.14 mg/L 0.913165266106443 +DTXSID2020892 Css 3compartmentss Human 95% 0.6773 mg/L 1.022 mg/L 0.662720156555773 +DTXSID2020894 Css 3compartmentss Human 95% 5.866 mg/L 6.363 mg/L 0.921892189218922 +DTXSID2020898 Css 3compartmentss Human 95% 4.51 mg/L 5.202 mg/L 0.866974240676663 +DTXSID2020921 Css 3compartmentss Human 95% 2.285 mg/L 2.46 mg/L 0.928861788617886 +DTXSID2020923 Css 3compartmentss Human 95% 0.9173 mg/L 1.873 mg/L 0.489749065670048 +DTXSID2020927 Css 3compartmentss Human 95% 2.195 mg/L 3.443 mg/L 0.637525413883241 +DTXSID2020929 Css 3compartmentss Human 95% 6.48 mg/L 2.746 mg/L 2.35979606700656 +DTXSID2020977 Css 3compartmentss Human 95% 7.336 mg/L 8.287 mg/L 0.885241945215398 +DTXSID2021022 Css 3compartmentss Human 95% 5.124 mg/L 1.037 mg/L 4.94117647058824 +DTXSID2021026 Css 3compartmentss Human 95% 1.392 mg/L NA NA NA +DTXSID2021028 Css 3compartmentss Human 95% 0.2766 mg/L 4.874 mg/L 0.0567501025851457 +DTXSID2021070 Css 3compartmentss Human 95% 2.098 mg/L 11.39 mg/L 0.184196663740123 +DTXSID2021151 Css 3compartmentss Human 95% 137.1 mg/L 147.9 mg/L 0.926977687626775 +DTXSID2021159 Css 3compartmentss Human 95% 7.838 mg/L 1.359 mg/L 5.76747608535688 +DTXSID2021232 Css 3compartmentss Human 95% 0.3253 mg/L 7.964 mg/L 0.0408463083877448 +DTXSID2021234 Css 3compartmentss Human 95% 1.92 mg/L 4.902 mg/L 0.391676866585067 +DTXSID2021236 Css 3compartmentss Human 95% 7.805 mg/L 0.3445 mg/L 22.656023222061 +DTXSID2021238 Css 3compartmentss Human 95% 0.3451 mg/L 0.3957 mg/L 0.872125347485469 +DTXSID20212769 Css 3compartmentss Human 95% 3.57 mg/L NA NA NA +DTXSID2021282 Css 3compartmentss Human 95% 3.298 mg/L 3.268 mg/L 1.00917992656059 +DTXSID2021286 Css 3compartmentss Human 95% 0.4538 mg/L 1.238 mg/L 0.366558966074313 +DTXSID2021288 Css 3compartmentss Human 95% 4.494 mg/L 5.151 mg/L 0.872451951077461 +DTXSID2021363 Css 3compartmentss Human 95% 0.3042 mg/L 1.801 mg/L 0.168906163242643 +DTXSID2021365 Css 3compartmentss Human 95% 0.374 mg/L 1.139 mg/L 0.328358208955224 +DTXSID2021367 Css 3compartmentss Human 95% 7.795 mg/L 0.1779 mg/L 43.8167509836987 +DTXSID2021440 Css 3compartmentss Human 95% 1.991 mg/L 1.982 mg/L 1.00454086781029 +DTXSID2021442 Css 3compartmentss Human 95% 4.936 mg/L 4.588 mg/L 1.07585004359198 +DTXSID2021448 Css 3compartmentss Human 95% 0.4177 mg/L 1.051 mg/L 0.397431018078021 +DTXSID2021498 Css 3compartmentss Human 95% 4.082 mg/L 5.806 mg/L 0.7030657940062 +DTXSID2021575 Css 3compartmentss Human 95% 7.256 mg/L 8.362 mg/L 0.867734991628797 +DTXSID2021577 Css 3compartmentss Human 95% 4.659 mg/L 5.338 mg/L 0.872798801049082 +DTXSID2021600 Css 3compartmentss Human 95% 8 mg/L 8.437 mg/L 0.948204338034847 +DTXSID2021602 Css 3compartmentss Human 95% 9.854 mg/L 663.3 mg/L 0.0148560229157244 +DTXSID20216489 Css 3compartmentss Human 95% 15.72 mg/L NA NA NA +DTXSID2021650 Css 3compartmentss Human 95% 6.46 mg/L 7.522 mg/L 0.858814145174156 +DTXSID2021652 Css 3compartmentss Human 95% 12.81 mg/L 571.4 mg/L 0.0224186209310466 +DTXSID2021654 Css 3compartmentss Human 95% 7.248 mg/L 8.153 mg/L 0.888997914877959 +DTXSID20216545 Css 3compartmentss Human 95% 0.521 mg/L NA NA NA +DTXSID2021656 Css 3compartmentss Human 95% 0.4177 mg/L 15.31 mg/L 0.0272828216851731 +DTXSID2021731 Css 3compartmentss Human 95% 1.343 mg/L 1.421 mg/L 0.945109078114004 +DTXSID2021735 Css 3compartmentss Human 95% 5.049 mg/L 5.558 mg/L 0.908420295070169 +DTXSID2021739 Css 3compartmentss Human 95% 5.763 mg/L 6.692 mg/L 0.861177525403467 +DTXSID2021781 Css 3compartmentss Human 95% 5.77 mg/L 5.706 mg/L 1.01121626358219 +DTXSID2021789 Css 3compartmentss Human 95% 0.3439 mg/L 0.1013 mg/L 3.39486673247779 +DTXSID2021810 Css 3compartmentss Human 95% 0.6311 mg/L 1.338 mg/L 0.471674140508221 +DTXSID2021860 Css 3compartmentss Human 95% 1.318 mg/L NA NA NA +DTXSID2021864 Css 3compartmentss Human 95% 0.6699 mg/L 1.249 mg/L 0.536349079263411 +DTXSID2021866 Css 3compartmentss Human 95% 9.138 mg/L 6.368 mg/L 1.43498743718593 +DTXSID2021941 Css 3compartmentss Human 95% 6.681 mg/L 3.247 mg/L 2.05759162303665 +DTXSID2021947 Css 3compartmentss Human 95% 12.81 mg/L 12.06 mg/L 1.06218905472637 +DTXSID2021949 Css 3compartmentss Human 95% 4.374 mg/L 4.977 mg/L 0.878842676311031 +DTXSID2021995 Css 3compartmentss Human 95% 1.954 mg/L 1.97 mg/L 0.991878172588832 +DTXSID2021997 Css 3compartmentss Human 95% 2.584 mg/L 2.614 mg/L 0.988523335883703 +DTXSID2022048 Css 3compartmentss Human 95% 16.34 mg/L 15.2 mg/L 1.075 +DTXSID2022090 Css 3compartmentss Human 95% 5.585 mg/L 4.887 mg/L 1.14282791078371 +DTXSID2022121 Css 3compartmentss Human 95% 33.05 mg/L 34.88 mg/L 0.947534403669725 +DTXSID2022123 Css 3compartmentss Human 95% 4.754 mg/L 3.023 mg/L 1.57260999007608 +DTXSID2022127 Css 3compartmentss Human 95% 10.71 mg/L 4.641 mg/L 2.30769230769231 +DTXSID2022171 Css 3compartmentss Human 95% 0.2366 mg/L NA NA NA +DTXSID2022254 Css 3compartmentss Human 95% 7.351 mg/L 7.234 mg/L 1.01617362455073 +DTXSID2022256 Css 3compartmentss Human 95% 11.6 mg/L 23.2 mg/L 0.5 +DTXSID20222742 Css 3compartmentss Human 95% 2.106 mg/L NA NA NA +DTXSID2022331 Css 3compartmentss Human 95% 3.222 mg/L 3.101 mg/L 1.03901967107385 +DTXSID20223355 Css 3compartmentss Human 95% 3.268 mg/L NA NA NA +DTXSID2022381 Css 3compartmentss Human 95% 7.707 mg/L 9.307 mg/L 0.828086386590738 +DTXSID2022389 Css 3compartmentss Human 95% 18.21 mg/L NA NA NA +DTXSID2022462 Css 3compartmentss Human 95% 6.871 mg/L 9.538 mg/L 0.72038163136926 +DTXSID2022541 Css 3compartmentss Human 95% 43 mg/L 60 mg/L 0.716666666666667 +DTXSID2022543 Css 3compartmentss Human 95% 0.3734 mg/L 3.613 mg/L 0.103349017437033 +DTXSID2022549 Css 3compartmentss Human 95% 57.11 mg/L 60.91 mg/L 0.93761287144968 +DTXSID2022593 Css 3compartmentss Human 95% 0.4112 mg/L 0.3717 mg/L 1.106268496099 +DTXSID2022595 Css 3compartmentss Human 95% 4.232 mg/L 44.94 mg/L 0.0941700044503783 +DTXSID2022597 Css 3compartmentss Human 95% 2.803 mg/L NA NA NA +DTXSID2022624 Css 3compartmentss Human 95% 4.584 mg/L 2.182 mg/L 2.10082493125573 +DTXSID2022628 Css 3compartmentss Human 95% 0.6571 mg/L 0.7776 mg/L 0.845036008230453 +DTXSID2022672 Css 3compartmentss Human 95% 4.152 mg/L 15.53 mg/L 0.267353509336768 +DTXSID2022674 Css 3compartmentss Human 95% 1.356 mg/L 1.678 mg/L 0.808104886769964 +DTXSID2022676 Css 3compartmentss Human 95% 5.408 mg/L 3.351 mg/L 1.61384661295136 +DTXSID2022678 Css 3compartmentss Human 95% 99.27 mg/L 132.2 mg/L 0.750907715582451 +DTXSID2022703 Css 3compartmentss Human 95% 7.293 mg/L 7.354 mg/L 0.991705194451999 +DTXSID2022705 Css 3compartmentss Human 95% 1.662 mg/L NA NA NA +DTXSID2022707 Css 3compartmentss Human 95% 8.673 mg/L 10.59 mg/L 0.818980169971671 +DTXSID2022751 Css 3compartmentss Human 95% 7.828 mg/L 9.3 mg/L 0.841720430107527 +DTXSID2022753 Css 3compartmentss Human 95% 10.24 mg/L 17.84 mg/L 0.573991031390135 +DTXSID2022755 Css 3compartmentss Human 95% 5.635 mg/L NA NA NA +DTXSID2022757 Css 3compartmentss Human 95% 1.443 mg/L NA NA NA +DTXSID2022759 Css 3compartmentss Human 95% 8.775 mg/L 15.45 mg/L 0.567961165048544 +DTXSID2022830 Css 3compartmentss Human 95% 4.57 mg/L NA NA NA +DTXSID2022836 Css 3compartmentss Human 95% 8.939 mg/L NA NA NA +DTXSID2022880 Css 3compartmentss Human 95% 18.55 mg/L 11.71 mg/L 1.58411614005124 +DTXSID2022888 Css 3compartmentss Human 95% 4.097 mg/L 6.418 mg/L 0.638360860081022 +DTXSID2022911 Css 3compartmentss Human 95% 1.886 mg/L NA NA NA +DTXSID2022915 Css 3compartmentss Human 95% 3.013 mg/L 5.505 mg/L 0.547320617620345 +DTXSID2022963 Css 3compartmentss Human 95% 6.342 mg/L NA NA NA +DTXSID2022967 Css 3compartmentss Human 95% 5.063 mg/L 8.882 mg/L 0.570029272686332 +DTXSID20230084 Css 3compartmentss Human 95% 6.072 mg/L NA NA NA +DTXSID2023010 Css 3compartmentss Human 95% 0.5691 mg/L 1.212 mg/L 0.469554455445545 +DTXSID2023016 Css 3compartmentss Human 95% 3.158 mg/L 6.506 mg/L 0.485398094067015 +DTXSID2023064 Css 3compartmentss Human 95% 0.7164 mg/L 0.3078 mg/L 2.32748538011696 +DTXSID2023068 Css 3compartmentss Human 95% 26.56 mg/L 3.006 mg/L 8.8356620093147 +DTXSID20230862 Css 3compartmentss Human 95% 0.9353 mg/L NA NA NA +DTXSID2023143 Css 3compartmentss Human 95% 3.115 mg/L 5.562 mg/L 0.56005034160374 +DTXSID2023145 Css 3compartmentss Human 95% 4.632 mg/L 8.176 mg/L 0.566536203522505 +DTXSID2023149 Css 3compartmentss Human 95% 9.183 mg/L 9.18 mg/L 1.00032679738562 +DTXSID2023191 Css 3compartmentss Human 95% 0.7556 mg/L 0.8216 mg/L 0.919668938656281 +DTXSID2023193 Css 3compartmentss Human 95% 4.458 mg/L 5.284 mg/L 0.843679031037093 +DTXSID2023195 Css 3compartmentss Human 95% 7.175 mg/L 2.847 mg/L 2.52019669827889 +DTXSID2023197 Css 3compartmentss Human 95% 7.539 mg/L 14.63 mg/L 0.515311004784689 +DTXSID2023222 Css 3compartmentss Human 95% 0.8211 mg/L 1.447 mg/L 0.56744989633725 +DTXSID2023224 Css 3compartmentss Human 95% 11.25 mg/L 11.08 mg/L 1.01534296028881 +DTXSID2023226 Css 3compartmentss Human 95% 7.05 mg/L 9.854 mg/L 0.71544550436371 +DTXSID2023270 Css 3compartmentss Human 95% 2.741 mg/L 2.652 mg/L 1.03355957767722 +DTXSID2023276 Css 3compartmentss Human 95% 3.298 mg/L 7.924 mg/L 0.416203937405351 +DTXSID2023278 Css 3compartmentss Human 95% 0.5059 mg/L NA NA NA +DTXSID2023303 Css 3compartmentss Human 95% 10.56 mg/L 6.053 mg/L 1.74458945977201 +DTXSID2023307 Css 3compartmentss Human 95% 9.509 mg/L 2.047 mg/L 4.64533463605276 +DTXSID2023309 Css 3compartmentss Human 95% 0.4523 mg/L 0.6282 mg/L 0.719993632601082 +DTXSID2023353 Css 3compartmentss Human 95% 3.073 mg/L 1.952 mg/L 1.57428278688525 +DTXSID2023357 Css 3compartmentss Human 95% 22.2 mg/L NA NA NA +DTXSID2023430 Css 3compartmentss Human 95% 34.73 mg/L 40.92 mg/L 0.848729227761486 +DTXSID2023434 Css 3compartmentss Human 95% 5.067 mg/L 5.261 mg/L 0.963124881201293 +DTXSID2023436 Css 3compartmentss Human 95% 4.38 mg/L 4.762 mg/L 0.919781604367913 +DTXSID2023480 Css 3compartmentss Human 95% 1.419 mg/L 4.504 mg/L 0.315053285968028 +DTXSID2023482 Css 3compartmentss Human 95% 0.3138 mg/L NA NA NA +DTXSID2023488 Css 3compartmentss Human 95% 10.45 mg/L 14.12 mg/L 0.740084985835694 +DTXSID2023515 Css 3compartmentss Human 95% 1.725 mg/L NA NA NA +DTXSID2023517 Css 3compartmentss Human 95% 4.404 mg/L 12.54 mg/L 0.351196172248804 +DTXSID2023519 Css 3compartmentss Human 95% 1.411 mg/L 25.72 mg/L 0.0548600311041991 +DTXSID2023565 Css 3compartmentss Human 95% 0.5314 mg/L 0.6023 mg/L 0.882284575792794 +DTXSID2023567 Css 3compartmentss Human 95% 1.803 mg/L 6.219 mg/L 0.289917993246503 +DTXSID2023569 Css 3compartmentss Human 95% 1.555 mg/L 7.67 mg/L 0.202737940026076 +DTXSID2023640 Css 3compartmentss Human 95% 19.98 mg/L 4.526 mg/L 4.41449403446752 +DTXSID2023642 Css 3compartmentss Human 95% 0.09919 mg/L 0.4276 mg/L 0.231969130028064 +DTXSID2023644 Css 3compartmentss Human 95% 7.354 mg/L 3.257 mg/L 2.2579060485109 +DTXSID2023648 Css 3compartmentss Human 95% 8.526 mg/L NA NA NA +DTXSID20236667 Css 3compartmentss Human 95% 1.505 mg/L NA NA NA +DTXSID2023690 Css 3compartmentss Human 95% 31.09 mg/L 30.78 mg/L 1.01007147498376 +DTXSID2023692 Css 3compartmentss Human 95% 1.453 mg/L 18.39 mg/L 0.079010331702012 +DTXSID2023721 Css 3compartmentss Human 95% 1.051 mg/L 0.04982 mg/L 21.0959454034524 +DTXSID2023723 Css 3compartmentss Human 95% 2.282 mg/L 2.823 mg/L 0.808359900814736 +DTXSID2023725 Css 3compartmentss Human 95% 0.8036 mg/L 0.04594 mg/L 17.4923813670004 +DTXSID2023727 Css 3compartmentss Human 95% 3.421 mg/L 99.16 mg/L 0.0344997983057685 +DTXSID2023729 Css 3compartmentss Human 95% 47.07 mg/L 48.35 mg/L 0.973526370217166 +DTXSID2023771 Css 3compartmentss Human 95% 6.911 mg/L 6.607 mg/L 1.04601180566066 +DTXSID2023775 Css 3compartmentss Human 95% 1.505 mg/L 30.95 mg/L 0.048626817447496 +DTXSID2024038 Css 3compartmentss Human 95% 0.2504 mg/L 6.232 mg/L 0.0401797175866496 +DTXSID20240825 Css 3compartmentss Human 95% 7.061 mg/L NA NA NA +DTXSID2024086 Css 3compartmentss Human 95% 231.8 mg/L 223.9 mg/L 1.03528360875391 +DTXSID2024113 Css 3compartmentss Human 95% 18.13 mg/L 11.86 mg/L 1.52866779089376 +DTXSID20241458 Css 3compartmentss Human 95% 103.2 mg/L NA NA NA +DTXSID2024163 Css 3compartmentss Human 95% 1.785 mg/L 1.82 mg/L 0.980769230769231 +DTXSID2024242 Css 3compartmentss Human 95% 5.138 mg/L 5.018 mg/L 1.02391390992427 +DTXSID2024452 Css 3compartmentss Human 95% 4.479 mg/L 3.871 mg/L 1.15706535778869 +DTXSID2024454 Css 3compartmentss Human 95% 0.3957 mg/L 1.67 mg/L 0.236946107784431 +DTXSID2024458 Css 3compartmentss Human 95% 19.64 mg/L 6.829 mg/L 2.87597012739786 +DTXSID2024585 Css 3compartmentss Human 95% 10.33 mg/L NA NA NA +DTXSID2024662 Css 3compartmentss Human 95% 0.9483 mg/L 0.6652 mg/L 1.42558628983764 +DTXSID2024664 Css 3compartmentss Human 95% 6.655 mg/L 5.746 mg/L 1.1581970066133 +DTXSID2024666 Css 3compartmentss Human 95% 6.173 mg/L 2.934 mg/L 2.10395364689843 +DTXSID2024747 Css 3compartmentss Human 95% 5.97 mg/L 2.9 mg/L 2.05862068965517 +DTXSID2024878 Css 3compartmentss Human 95% 6.563 mg/L 5.343 mg/L 1.2283361407449 +DTXSID2024953 Css 3compartmentss Human 95% 0.2447 mg/L 0.4143 mg/L 0.590634805696355 +DTXSID2025004 Css 3compartmentss Human 95% 2.145 mg/L 163.6 mg/L 0.0131112469437653 +DTXSID2025006 Css 3compartmentss Human 95% 3.371 mg/L 5.222 mg/L 0.645538108004596 +DTXSID2025050 Css 3compartmentss Human 95% 0.5275 mg/L 0.6218 mg/L 0.84834351881634 +DTXSID2025058 Css 3compartmentss Human 95% 0.3297 mg/L 0.3819 mg/L 0.86331500392773 +DTXSID2025133 Css 3compartmentss Human 95% 0.1865 mg/L 0.06468 mg/L 2.88342609771181 +DTXSID2025135 Css 3compartmentss Human 95% 4.114 mg/L 2.999 mg/L 1.37179059686562 +DTXSID2025137 Css 3compartmentss Human 95% 3.917 mg/L 2.57 mg/L 1.52412451361868 +DTXSID2025183 Css 3compartmentss Human 95% 9.199 mg/L 4.386 mg/L 2.09735522115823 +DTXSID2025210 Css 3compartmentss Human 95% 4.04 mg/L 35.18 mg/L 0.114837976122797 +DTXSID2025264 Css 3compartmentss Human 95% 0.6844 mg/L 0.1375 mg/L 4.97745454545455 +DTXSID2025345 Css 3compartmentss Human 95% 0.4234 mg/L 1.091 mg/L 0.388084326306141 +DTXSID2025347 Css 3compartmentss Human 95% 7.439 mg/L 0.9632 mg/L 7.72321428571429 +DTXSID2025391 Css 3compartmentss Human 95% 0.3338 mg/L 0.206 mg/L 1.62038834951456 +DTXSID2025422 Css 3compartmentss Human 95% 0.4629 mg/L 3.828 mg/L 0.120924764890282 +DTXSID2025501 Css 3compartmentss Human 95% 2.358 mg/L 13.91 mg/L 0.169518332135155 +DTXSID2025503 Css 3compartmentss Human 95% 10.9 mg/L 5.655 mg/L 1.92749778956676 +DTXSID2025505 Css 3compartmentss Human 95% 3.943 mg/L 731.5 mg/L 0.00539029391660971 +DTXSID2025551 Css 3compartmentss Human 95% 0.7327 mg/L NA NA NA +DTXSID2025557 Css 3compartmentss Human 95% 5.079 mg/L NA NA NA +DTXSID2025632 Css 3compartmentss Human 95% 0.5592 mg/L 0.8921 mg/L 0.626835556551956 +DTXSID2025634 Css 3compartmentss Human 95% 0.5322 mg/L 1.244 mg/L 0.427813504823151 +DTXSID2025688 Css 3compartmentss Human 95% 1.875 mg/L 2.197 mg/L 0.853436504324078 +DTXSID2025715 Css 3compartmentss Human 95% 2.076 mg/L 2.4 mg/L 0.865 +DTXSID2025761 Css 3compartmentss Human 95% 8.486 mg/L 9.893 mg/L 0.857778227029213 +DTXSID2025763 Css 3compartmentss Human 95% 0.5139 mg/L 0.9622 mg/L 0.534088547079609 +DTXSID2025765 Css 3compartmentss Human 95% 0.6621 mg/L 1.456 mg/L 0.454739010989011 +DTXSID2025842 Css 3compartmentss Human 95% 0.3856 mg/L 3.833 mg/L 0.10060005217845 +DTXSID2025892 Css 3compartmentss Human 95% 7.48 mg/L 7.559 mg/L 0.989548882127266 +DTXSID2025896 Css 3compartmentss Human 95% 8.185 mg/L 0.6111 mg/L 13.3938798887253 +DTXSID2025925 Css 3compartmentss Human 95% 0.5296 mg/L 0.06002 mg/L 8.82372542485838 +DTXSID2025977 Css 3compartmentss Human 95% 0.3691 mg/L 1.329 mg/L 0.277727614747931 +DTXSID2026074 Css 3compartmentss Human 95% 11.14 mg/L 2.454 mg/L 4.53952730236349 +DTXSID2026101 Css 3compartmentss Human 95% 22.44 mg/L 181.3 mg/L 0.123772752344181 +DTXSID2026107 Css 3compartmentss Human 95% 0.345 mg/L 1.81 mg/L 0.19060773480663 +DTXSID2026157 Css 3compartmentss Human 95% 0.7329 mg/L 0.7422 mg/L 0.987469684721099 +DTXSID2026232 Css 3compartmentss Human 95% 8.31 mg/L 4.089 mg/L 2.03228173147469 +DTXSID2026444 Css 3compartmentss Human 95% 5.143 mg/L 5.555 mg/L 0.925832583258326 +DTXSID2026446 Css 3compartmentss Human 95% 1.379 mg/L 1.125 mg/L 1.22577777777778 +DTXSID2026448 Css 3compartmentss Human 95% 5.215 mg/L 5.852 mg/L 0.891148325358852 +DTXSID2026494 Css 3compartmentss Human 95% 56.91 mg/L NA NA NA +DTXSID2026523 Css 3compartmentss Human 95% 8.347 mg/L 8.499 mg/L 0.982115543005059 +DTXSID2026525 Css 3compartmentss Human 95% 280.3 mg/L 279.4 mg/L 1.00322118826056 +DTXSID2026527 Css 3compartmentss Human 95% 1.365 mg/L 3.586 mg/L 0.380646960401562 +DTXSID2026529 Css 3compartmentss Human 95% 5.071 mg/L 3.948 mg/L 1.28444782168186 +DTXSID2026573 Css 3compartmentss Human 95% 2.535 mg/L 2.085 mg/L 1.2158273381295 +DTXSID2026600 Css 3compartmentss Human 95% 6.212 mg/L 7.731 mg/L 0.803518302936231 +DTXSID2026606 Css 3compartmentss Human 95% 0.6955 mg/L 0.9101 mg/L 0.764201736072959 +DTXSID2026608 Css 3compartmentss Human 95% 5.535 mg/L 8.335 mg/L 0.664067186562687 +DTXSID2026739 Css 3compartmentss Human 95% 0.3825 mg/L 0.02981 mg/L 12.8312646762831 +DTXSID2026783 Css 3compartmentss Human 95% 5.161 mg/L 5.613 mg/L 0.919472652770354 +DTXSID2026789 Css 3compartmentss Human 95% 5.651 mg/L 6.141 mg/L 0.920208435108289 +DTXSID2026941 Css 3compartmentss Human 95% 89.49 mg/L NA NA NA +DTXSID2026943 Css 3compartmentss Human 95% 5.058 mg/L 5.531 mg/L 0.91448201048635 +DTXSID2026991 Css 3compartmentss Human 95% 7.294 mg/L 0.02406 mg/L 303.158769742311 +DTXSID2026997 Css 3compartmentss Human 95% 0.5364 mg/L 0.2081 mg/L 2.57760691975012 +DTXSID2027044 Css 3compartmentss Human 95% 8.567 mg/L 9.805 mg/L 0.873737888832228 +DTXSID2027048 Css 3compartmentss Human 95% 8.957 mg/L 8.649 mg/L 1.03561105330096 +DTXSID2027092 Css 3compartmentss Human 95% 6.074 mg/L 1.137 mg/L 5.34212840809147 +DTXSID2027094 Css 3compartmentss Human 95% 3.594 mg/L 30.79 mg/L 0.116726209808379 +DTXSID2027096 Css 3compartmentss Human 95% 5.834 mg/L 7.035 mg/L 0.829282160625444 +DTXSID2027098 Css 3compartmentss Human 95% 5.633 mg/L 6.461 mg/L 0.871846463395759 +DTXSID2027175 Css 3compartmentss Human 95% 2.566 mg/L 2.204 mg/L 1.16424682395644 +DTXSID2027206 Css 3compartmentss Human 95% 0.2626 mg/L 5.565 mg/L 0.0471877807726864 +DTXSID2027333 Css 3compartmentss Human 95% 7.968 mg/L 0.02311 mg/L 344.785807009952 +DTXSID2027412 Css 3compartmentss Human 95% 7.466 mg/L 7.219 mg/L 1.0342152652722 +DTXSID2027414 Css 3compartmentss Human 95% 6.794 mg/L 6.958 mg/L 0.976430008623168 +DTXSID2027418 Css 3compartmentss Human 95% 6.387 mg/L 5.656 mg/L 1.129243281471 +DTXSID20274180 Css 3compartmentss Human 95% 2.811 mg/L NA NA NA +DTXSID2027462 Css 3compartmentss Human 95% 1.299 mg/L 74.8 mg/L 0.0173663101604278 +DTXSID2027466 Css 3compartmentss Human 95% 6.947 mg/L 1.698 mg/L 4.09128386336867 +DTXSID2027543 Css 3compartmentss Human 95% 6.139 mg/L 3.1 mg/L 1.98032258064516 +DTXSID2027591 Css 3compartmentss Human 95% 5.647 mg/L 1.066 mg/L 5.29737335834897 +DTXSID2027595 Css 3compartmentss Human 95% 7.659 mg/L 2.473 mg/L 3.09704811969268 +DTXSID2027599 Css 3compartmentss Human 95% 6.727 mg/L 8.057 mg/L 0.834926151172893 +DTXSID2027620 Css 3compartmentss Human 95% 0.351 mg/L 0.4793 mg/L 0.732317963697058 +DTXSID2027624 Css 3compartmentss Human 95% 0.4033 mg/L 3.127 mg/L 0.128973456987528 +DTXSID2027759 Css 3compartmentss Human 95% 5.463 mg/L 4.674 mg/L 1.16880616174583 +DTXSID2027830 Css 3compartmentss Human 95% 1.712 mg/L 1.582 mg/L 1.08217446270544 +DTXSID2027834 Css 3compartmentss Human 95% 5.866 mg/L 3.232 mg/L 1.81497524752475 +DTXSID2027886 Css 3compartmentss Human 95% 15.2 mg/L 30.12 mg/L 0.50464807436919 +DTXSID2028010 Css 3compartmentss Human 95% 0.3423 mg/L 6.148 mg/L 0.0556766428106701 +DTXSID2029117 Css 3compartmentss Human 95% 22.91 mg/L 11.12 mg/L 2.06025179856115 +DTXSID2029167 Css 3compartmentss Human 95% 1.248 mg/L 1.461 mg/L 0.854209445585216 +DTXSID2029169 Css 3compartmentss Human 95% 3.836 mg/L 3313 mg/L 0.00115786296408089 +DTXSID2029242 Css 3compartmentss Human 95% 6.426 mg/L 0.09504 mg/L 67.6136363636364 +DTXSID2029325 Css 3compartmentss Human 95% 1.172 mg/L 31.13 mg/L 0.0376485705107613 +DTXSID2029616 Css 3compartmentss Human 95% 2.754 mg/L 3.463 mg/L 0.795264221773029 +DTXSID2029874 Css 3compartmentss Human 95% 0.8823 mg/L 0.8854 mg/L 0.996498757623673 +DTXSID2030695 Css 3compartmentss Human 95% 13.96 mg/L 12.16 mg/L 1.14802631578947 +DTXSID2031089 Css 3compartmentss Human 95% 10890 mg/L NA NA NA +DTXSID2031374 Css 3compartmentss Human 95% 4.517 mg/L 5.492 mg/L 0.822469045884924 +DTXSID2031956 Css 3compartmentss Human 95% 0.3824 mg/L 0.2955 mg/L 1.29407783417936 +DTXSID20319722 Css 3compartmentss Human 95% 2.179 mg/L NA NA NA +DTXSID2032005 Css 3compartmentss Human 95% 20.66 mg/L 135.1 mg/L 0.152923760177646 +DTXSID2032180 Css 3compartmentss Human 95% 7533 mg/L 8615 mg/L 0.874405107370865 +DTXSID2032342 Css 3compartmentss Human 95% 6.206 mg/L 25.22 mg/L 0.246074544012688 +DTXSID2032344 Css 3compartmentss Human 95% 0.7912 mg/L 0.7969 mg/L 0.992847283222487 +DTXSID2032348 Css 3compartmentss Human 95% 11470 mg/L 13700 mg/L 0.837226277372263 +DTXSID2032390 Css 3compartmentss Human 95% 24.54 mg/L 28.84 mg/L 0.850901525658807 +DTXSID2032392 Css 3compartmentss Human 95% 1703 mg/L 916.9 mg/L 1.85734540298833 +DTXSID2032398 Css 3compartmentss Human 95% 21.82 mg/L 23.79 mg/L 0.917192097519966 +DTXSID2032500 Css 3compartmentss Human 95% 18.06 mg/L 18.41 mg/L 0.980988593155893 +DTXSID2032502 Css 3compartmentss Human 95% 0.5212 mg/L 0.5771 mg/L 0.903136371512736 +DTXSID2032550 Css 3compartmentss Human 95% 25.4 mg/L 26 mg/L 0.976923076923077 +DTXSID2032552 Css 3compartmentss Human 95% 1.323 mg/L 1.758 mg/L 0.752559726962457 +DTXSID2032554 Css 3compartmentss Human 95% 0.806 mg/L 0.9159 mg/L 0.880008734578011 +DTXSID2032556 Css 3compartmentss Human 95% 0.161 mg/L NA NA NA +DTXSID2032558 Css 3compartmentss Human 95% 10.06 mg/L 0.4208 mg/L 23.9068441064639 +DTXSID2032631 Css 3compartmentss Human 95% 1.01 mg/L 3.948 mg/L 0.255825734549139 +DTXSID2032637 Css 3compartmentss Human 95% 0.5159 mg/L 0.5496 mg/L 0.938682678311499 +DTXSID2032639 Css 3compartmentss Human 95% 4.218 mg/L 38.17 mg/L 0.110505632695834 +DTXSID2032683 Css 3compartmentss Human 95% 0.5036 mg/L 0.5151 mg/L 0.977674238012037 +DTXSID2032891 Css 3compartmentss Human 95% 9.072 mg/L 14.38 mg/L 0.630876216968011 +DTXSID2033281 Css 3compartmentss Human 95% 8.591 mg/L 9.805 mg/L 0.876185619581846 +DTXSID2033314 Css 3compartmentss Human 95% 0.2386 mg/L 0.4279 mg/L 0.55760691750409 +DTXSID2033445 Css 3compartmentss Human 95% 8.063 mg/L 0.6469 mg/L 12.4640593600247 +DTXSID2033493 Css 3compartmentss Human 95% 0.2892 mg/L 1.692 mg/L 0.170921985815603 +DTXSID2033736 Css 3compartmentss Human 95% 1.743 mg/L 0.2926 mg/L 5.95693779904306 +DTXSID2034091 Css 3compartmentss Human 95% 0.3557 mg/L 6.738 mg/L 0.0527901454437519 +DTXSID2034095 Css 3compartmentss Human 95% 3.972 mg/L 0.09649 mg/L 41.1648875531143 +DTXSID20342515 Css 3compartmentss Human 95% 20.04 mg/L NA NA NA +DTXSID2034255 Css 3compartmentss Human 95% 5.402 mg/L 6.413 mg/L 0.842351473569312 +DTXSID2034259 Css 3compartmentss Human 95% 6.319 mg/L 2.429 mg/L 2.60148209139564 +DTXSID2034338 Css 3compartmentss Human 95% 1.397 mg/L 3.183 mg/L 0.438894125039271 +DTXSID2034382 Css 3compartmentss Human 95% 19.94 mg/L 6.853 mg/L 2.90967459506785 +DTXSID2034465 Css 3compartmentss Human 95% 0.6682 mg/L 0.6694 mg/L 0.998207349865551 +DTXSID2034540 Css 3compartmentss Human 95% 7.746 mg/L 8.522 mg/L 0.908941563013377 +DTXSID2034542 Css 3compartmentss Human 95% 0.7033 mg/L 0.9953 mg/L 0.706621119260525 +DTXSID2034590 Css 3compartmentss Human 95% 13.24 mg/L 13.52 mg/L 0.979289940828402 +DTXSID2034598 Css 3compartmentss Human 95% 0.8156 mg/L 0.7601 mg/L 1.07301670832785 +DTXSID2034625 Css 3compartmentss Human 95% 9.444 mg/L 10.98 mg/L 0.860109289617486 +DTXSID2034627 Css 3compartmentss Human 95% 15.83 mg/L 16.35 mg/L 0.968195718654434 +DTXSID2034673 Css 3compartmentss Human 95% 140.6 mg/L 146 mg/L 0.963013698630137 +DTXSID2034700 Css 3compartmentss Human 95% 60.02 mg/L 33.47 mg/L 1.79324768449358 +DTXSID2034833 Css 3compartmentss Human 95% 1.351 mg/L 104.7 mg/L 0.0129035339063992 +DTXSID2034881 Css 3compartmentss Human 95% 1348 mg/L 872.6 mg/L 1.54480861792345 +DTXSID2034885 Css 3compartmentss Human 95% 19.21 mg/L 7.172 mg/L 2.67847183491355 +DTXSID2034962 Css 3compartmentss Human 95% 5.756 mg/L 5.736 mg/L 1.00348675034868 +DTXSID2034968 Css 3compartmentss Human 95% 1.668 mg/L 2.127 mg/L 0.784203102961918 +DTXSID2035481 Css 3compartmentss Human 95% 0.7286 mg/L 1.27 mg/L 0.573700787401575 +DTXSID2036112 Css 3compartmentss Human 95% 1.559 mg/L 1.431 mg/L 1.08944793850454 +DTXSID2036409 Css 3compartmentss Human 95% 5.072 mg/L 5.506 mg/L 0.921176897929531 +DTXSID2036827 Css 3compartmentss Human 95% 1.445 mg/L 9.947 mg/L 0.145269930632351 +DTXSID2037186 Css 3compartmentss Human 95% 35.66 mg/L 9.774 mg/L 3.64845508491917 +DTXSID2037502 Css 3compartmentss Human 95% 19.74 mg/L 8.421 mg/L 2.34413965087282 +DTXSID2037712 Css 3compartmentss Human 95% 6.871 mg/L 7.154 mg/L 0.960441710930948 +DTXSID2037714 Css 3compartmentss Human 95% 13.56 mg/L 12.9 mg/L 1.05116279069767 +DTXSID2038443 Css 3compartmentss Human 95% 2.9 mg/L NA NA NA +DTXSID2038732 Css 3compartmentss Human 95% 0.3781 mg/L 0.1454 mg/L 2.60041265474553 +DTXSID2038788 Css 3compartmentss Human 95% 6.514 mg/L 6.916 mg/L 0.941873915558126 +DTXSID2038813 Css 3compartmentss Human 95% 7.854 mg/L 0.7933 mg/L 9.90041598386487 +DTXSID2038817 Css 3compartmentss Human 95% 6.97 mg/L NA NA NA +DTXSID2039336 Css 3compartmentss Human 95% 52.23 mg/L 48.01 mg/L 1.08789835450948 +DTXSID2040151 Css 3compartmentss Human 95% 0.1989 mg/L 0.2338 mg/L 0.850727117194183 +DTXSID2040234 Css 3compartmentss Human 95% 5.347 mg/L 2.919 mg/L 1.83179170948955 +DTXSID2040236 Css 3compartmentss Human 95% 8.297 mg/L 1.845 mg/L 4.4970189701897 +DTXSID2040284 Css 3compartmentss Human 95% 150.3 mg/L 35.32 mg/L 4.25537938844847 +DTXSID2040361 Css 3compartmentss Human 95% 1.248 mg/L 1.461 mg/L 0.854209445585216 +DTXSID2040363 Css 3compartmentss Human 95% 330.3 mg/L 342.3 mg/L 0.964943032427695 +DTXSID2040446 Css 3compartmentss Human 95% 0.138 mg/L NA NA NA +DTXSID2040525 Css 3compartmentss Human 95% 2.971 mg/L 18.13 mg/L 0.163872035300607 +DTXSID2040579 Css 3compartmentss Human 95% 1.774 mg/L 4.437 mg/L 0.39981969799414 +DTXSID2040608 Css 3compartmentss Human 95% 1.032 mg/L 0.2119 mg/L 4.87022180273714 +DTXSID2040652 Css 3compartmentss Human 95% 1.145 mg/L 1.122 mg/L 1.0204991087344 +DTXSID2040656 Css 3compartmentss Human 95% 7.818 mg/L 5.36 mg/L 1.45858208955224 +DTXSID2040731 Css 3compartmentss Human 95% 1.982 mg/L 1.324 mg/L 1.49697885196375 +DTXSID2040735 Css 3compartmentss Human 95% 0.6773 mg/L 9.273 mg/L 0.0730400086271972 +DTXSID2040739 Css 3compartmentss Human 95% 4.49 mg/L 5.668 mg/L 0.792166549047283 +DTXSID2040783 Css 3compartmentss Human 95% 13.53 mg/L 4.442 mg/L 3.04592525889239 +DTXSID2040789 Css 3compartmentss Human 95% 14.02 mg/L NA NA NA +DTXSID2040945 Css 3compartmentss Human 95% 10.83 mg/L 0.3097 mg/L 34.9693251533742 +DTXSID2040949 Css 3compartmentss Human 95% 19.06 mg/L NA NA NA +DTXSID2041046 Css 3compartmentss Human 95% 0.3579 mg/L 1.572 mg/L 0.227671755725191 +DTXSID2041200 Css 3compartmentss Human 95% 2.816 mg/L 1.686 mg/L 1.67022538552788 +DTXSID2041208 Css 3compartmentss Human 95% 0.7873 mg/L 13.96 mg/L 0.0563968481375358 +DTXSID2041250 Css 3compartmentss Human 95% 483.6 mg/L 504.1 mg/L 0.959333465582226 +DTXSID2041252 Css 3compartmentss Human 95% 3.153 mg/L 19.65 mg/L 0.160458015267176 +DTXSID2041256 Css 3compartmentss Human 95% 2.894 mg/L 3.367 mg/L 0.85951885951886 +DTXSID2041389 Css 3compartmentss Human 95% 6.698 mg/L 4.94 mg/L 1.35587044534413 +DTXSID2041412 Css 3compartmentss Human 95% 5.096 mg/L 5.558 mg/L 0.916876574307305 +DTXSID2041418 Css 3compartmentss Human 95% 7.596 mg/L 8.138 mg/L 0.933398869501106 +DTXSID2041460 Css 3compartmentss Human 95% 62.92 mg/L 29.24 mg/L 2.15184678522572 +DTXSID2041464 Css 3compartmentss Human 95% 1.367 mg/L 1.402 mg/L 0.975035663338089 +DTXSID2041468 Css 3compartmentss Human 95% 2.364 mg/L 22.52 mg/L 0.104973357015986 +DTXSID2041545 Css 3compartmentss Human 95% 1.178 mg/L 13.77 mg/L 0.0855482933914306 +DTXSID2041547 Css 3compartmentss Human 95% 7.77 mg/L 6.184 mg/L 1.25646830530401 +DTXSID2041591 Css 3compartmentss Human 95% 7.584 mg/L NA NA NA +DTXSID2041622 Css 3compartmentss Human 95% 6.91 mg/L 0.486 mg/L 14.2181069958848 +DTXSID2041626 Css 3compartmentss Human 95% 1.668 mg/L NA NA NA +DTXSID2041672 Css 3compartmentss Human 95% 0.6296 mg/L 0.145 mg/L 4.34206896551724 +DTXSID2041709 Css 3compartmentss Human 95% 3.111 mg/L 8.689 mg/L 0.358038899758315 +DTXSID20417439 Css 3compartmentss Human 95% 6.456 mg/L NA NA NA +DTXSID2041880 Css 3compartmentss Human 95% 7.6 mg/L 0.006537 mg/L 1162.61281933609 +DTXSID2041884 Css 3compartmentss Human 95% 16.71 mg/L 0.237 mg/L 70.5063291139241 +DTXSID2041886 Css 3compartmentss Human 95% 0.4109 mg/L 0.02265 mg/L 18.1412803532009 +DTXSID2041913 Css 3compartmentss Human 95% 2.494 mg/L 6.362 mg/L 0.392015089594467 +DTXSID2041917 Css 3compartmentss Human 95% 3.966 mg/L 3.659 mg/L 1.08390270565728 +DTXSID2042014 Css 3compartmentss Human 95% 5.117 mg/L 6.109 mg/L 0.837616631199869 +DTXSID2042060 Css 3compartmentss Human 95% 1.333 mg/L 27.38 mg/L 0.0486851716581446 +DTXSID2042143 Css 3compartmentss Human 95% 3.598 mg/L 0.871 mg/L 4.1308840413318 +DTXSID2042149 Css 3compartmentss Human 95% 8.193 mg/L 0.3483 mg/L 23.5228251507321 +DTXSID2042191 Css 3compartmentss Human 95% 5.501 mg/L 1.226 mg/L 4.48694942903752 +DTXSID2042195 Css 3compartmentss Human 95% 20.72 mg/L 20.77 mg/L 0.997592681752528 +DTXSID2042220 Css 3compartmentss Human 95% 6.323 mg/L 3.945 mg/L 1.60278833967047 +DTXSID2042276 Css 3compartmentss Human 95% 0.4839 mg/L 1.071 mg/L 0.451820728291317 +DTXSID2042436 Css 3compartmentss Human 95% 59.99 mg/L 134.3 mg/L 0.44668652271035 +DTXSID2042511 Css 3compartmentss Human 95% 1.455 mg/L NA NA NA +DTXSID2042648 Css 3compartmentss Human 95% 3.451 mg/L NA NA NA +DTXSID20434520 Css 3compartmentss Human 95% 3.283 mg/L NA NA NA +DTXSID2043828 Css 3compartmentss Human 95% 1.17 mg/L NA NA NA +DTXSID2043874 Css 3compartmentss Human 95% 0.2336 mg/L 0.2873 mg/L 0.813087365123564 +DTXSID2043903 Css 3compartmentss Human 95% 2.286 mg/L 11.18 mg/L 0.204472271914132 +DTXSID2043909 Css 3compartmentss Human 95% 1.224 mg/L 1.133 mg/L 1.08031774051192 +DTXSID2043951 Css 3compartmentss Human 95% 10.39 mg/L NA NA NA +DTXSID2044000 Css 3compartmentss Human 95% 0.5282 mg/L 1.524 mg/L 0.346587926509186 +DTXSID2044002 Css 3compartmentss Human 95% 1.255 mg/L 0.1662 mg/L 7.5511432009627 +DTXSID2044131 Css 3compartmentss Human 95% 2.945 mg/L 23.21 mg/L 0.126884963377854 +DTXSID2044137 Css 3compartmentss Human 95% 0.9874 mg/L 0.3714 mg/L 2.65858912224017 +DTXSID2044210 Css 3compartmentss Human 95% 6.238 mg/L 2.671 mg/L 2.33545488581056 +DTXSID2044214 Css 3compartmentss Human 95% 1.644 mg/L 5.226 mg/L 0.314580941446613 +DTXSID2044218 Css 3compartmentss Human 95% 3.878 mg/L 6.71 mg/L 0.577943368107303 +DTXSID2044266 Css 3compartmentss Human 95% 0.8259 mg/L 0.3702 mg/L 2.23095623987034 +DTXSID2044268 Css 3compartmentss Human 95% 1.686 mg/L 2.864 mg/L 0.588687150837989 +DTXSID2044347 Css 3compartmentss Human 95% 0.5775 mg/L 0.2358 mg/L 2.44910941475827 +DTXSID2044391 Css 3compartmentss Human 95% 2.364 mg/L 2.669 mg/L 0.885724990633196 +DTXSID2044393 Css 3compartmentss Human 95% 7.487 mg/L 5.351 mg/L 1.39917772378995 +DTXSID2044397 Css 3compartmentss Human 95% 6.986 mg/L 8.051 mg/L 0.867718295863868 +DTXSID2044399 Css 3compartmentss Human 95% 7.982 mg/L 7.635 mg/L 1.04544859201048 +DTXSID2044420 Css 3compartmentss Human 95% 119 mg/L 42.39 mg/L 2.80726586459071 +DTXSID2044422 Css 3compartmentss Human 95% 6.977 mg/L 0.01106 mg/L 630.831826401447 +DTXSID2044424 Css 3compartmentss Human 95% 5.697 mg/L 2.199 mg/L 2.59072305593452 +DTXSID2044428 Css 3compartmentss Human 95% 0.8496 mg/L 0.2478 mg/L 3.42857142857143 +DTXSID2044472 Css 3compartmentss Human 95% 0.3271 mg/L 5.512 mg/L 0.0593432510885341 +DTXSID2044474 Css 3compartmentss Human 95% 0.6938 mg/L 3.036 mg/L 0.228524374176548 +DTXSID2044501 Css 3compartmentss Human 95% 9.783 mg/L NA NA NA +DTXSID2044503 Css 3compartmentss Human 95% 7.117 mg/L 551.5 mg/L 0.0129048050770626 +DTXSID2044507 Css 3compartmentss Human 95% 52.96 mg/L 1.537 mg/L 34.4567338972023 +DTXSID2044509 Css 3compartmentss Human 95% 60.56 mg/L 504 mg/L 0.12015873015873 +DTXSID2044553 Css 3compartmentss Human 95% 0.3235 mg/L 7.87 mg/L 0.0411054637865311 +DTXSID2044632 Css 3compartmentss Human 95% 2.091 mg/L 2.275 mg/L 0.919120879120879 +DTXSID2044638 Css 3compartmentss Human 95% 1.374 mg/L 0.5737 mg/L 2.39497995468015 +DTXSID2044680 Css 3compartmentss Human 95% 6.705 mg/L 3.151 mg/L 2.12789590606157 +DTXSID2044682 Css 3compartmentss Human 95% 5.373 mg/L 3.507 mg/L 1.53207869974337 +DTXSID2044684 Css 3compartmentss Human 95% 7.718 mg/L 10.89 mg/L 0.70872359963269 +DTXSID2044686 Css 3compartmentss Human 95% 6.76 mg/L 1.181 mg/L 5.72396274343776 +DTXSID2044713 Css 3compartmentss Human 95% 7.096 mg/L 963.6 mg/L 0.00736405147364051 +DTXSID2044715 Css 3compartmentss Human 95% 1.063 mg/L 0.8902 mg/L 1.19411368231858 +DTXSID2044717 Css 3compartmentss Human 95% 9.692 mg/L 50.38 mg/L 0.192377927749107 +DTXSID2044719 Css 3compartmentss Human 95% 29.66 mg/L 3.097 mg/L 9.57701000968679 +DTXSID2044763 Css 3compartmentss Human 95% 1.593 mg/L 0.6357 mg/L 2.50589900896649 +DTXSID2044765 Css 3compartmentss Human 95% 1.979 mg/L NA NA NA +DTXSID2044767 Css 3compartmentss Human 95% 8.513 mg/L 1.132 mg/L 7.52031802120141 +DTXSID2044840 Css 3compartmentss Human 95% 5.087 mg/L 7.136 mg/L 0.712864349775785 +DTXSID2044842 Css 3compartmentss Human 95% 15.14 mg/L 0.007238 mg/L 2091.73804918486 +DTXSID2044844 Css 3compartmentss Human 95% 0.2534 mg/L 0.1217 mg/L 2.08216926869351 +DTXSID2044846 Css 3compartmentss Human 95% 2.402 mg/L 1.126 mg/L 2.13321492007105 +DTXSID2044848 Css 3compartmentss Human 95% 0.2731 mg/L 1.578 mg/L 0.173067173637516 +DTXSID2044890 Css 3compartmentss Human 95% 1.738 mg/L 1.812 mg/L 0.95916114790287 +DTXSID2044892 Css 3compartmentss Human 95% 7.131 mg/L 4.272 mg/L 1.66924157303371 +DTXSID2044896 Css 3compartmentss Human 95% 1.351 mg/L 1.532 mg/L 0.881853785900783 +DTXSID2044898 Css 3compartmentss Human 95% 2.027 mg/L 0.5034 mg/L 4.02661899086214 +DTXSID2044925 Css 3compartmentss Human 95% 27.83 mg/L 114.8 mg/L 0.242421602787456 +DTXSID2044927 Css 3compartmentss Human 95% 15.17 mg/L 7.676 mg/L 1.97628973423658 +DTXSID2044971 Css 3compartmentss Human 95% 21.86 mg/L 8.547 mg/L 2.55762255762256 +DTXSID2044975 Css 3compartmentss Human 95% 6.928 mg/L 0.1538 mg/L 45.0455136540962 +DTXSID2044979 Css 3compartmentss Human 95% 1.546 mg/L 4.886 mg/L 0.316414244781007 +DTXSID2045072 Css 3compartmentss Human 95% 30.79 mg/L 253.4 mg/L 0.121507498026835 +DTXSID2045076 Css 3compartmentss Human 95% 4.583 mg/L 10.72 mg/L 0.427518656716418 +DTXSID2045078 Css 3compartmentss Human 95% 5.696 mg/L 6.861 mg/L 0.830199679347034 +DTXSID2045101 Css 3compartmentss Human 95% 1.046 mg/L 7.316 mg/L 0.142974302897758 +DTXSID2045103 Css 3compartmentss Human 95% 0.6842 mg/L 0.2362 mg/L 2.89669771380186 +DTXSID2045105 Css 3compartmentss Human 95% 0.579 mg/L 2.395 mg/L 0.241753653444676 +DTXSID2045107 Css 3compartmentss Human 95% 7.355 mg/L 8.681 mg/L 0.847252620665822 +DTXSID2045109 Css 3compartmentss Human 95% 3.324 mg/L 0.7452 mg/L 4.46054750402577 +DTXSID2045151 Css 3compartmentss Human 95% 2.942 mg/L 3.069 mg/L 0.95861844248941 +DTXSID2045153 Css 3compartmentss Human 95% 0.3407 mg/L 1.923 mg/L 0.177171086843474 +DTXSID2045157 Css 3compartmentss Human 95% 1.953 mg/L 0.04727 mg/L 41.3158451449122 +DTXSID2045232 Css 3compartmentss Human 95% 46.55 mg/L 33.29 mg/L 1.3983178131571 +DTXSID2045236 Css 3compartmentss Human 95% 15.16 mg/L 17.31 mg/L 0.87579433853264 +DTXSID2045238 Css 3compartmentss Human 95% 4.993 mg/L 1.028 mg/L 4.85700389105058 +DTXSID2045280 Css 3compartmentss Human 95% 0.5932 mg/L 0.1933 mg/L 3.06880496637351 +DTXSID2045315 Css 3compartmentss Human 95% 0.5029 mg/L 28.43 mg/L 0.0176890608512135 +DTXSID2045361 Css 3compartmentss Human 95% 4.829 mg/L 4.476 mg/L 1.07886505808758 +DTXSID2045365 Css 3compartmentss Human 95% 9.803 mg/L 9.338 mg/L 1.04979653030628 +DTXSID2045367 Css 3compartmentss Human 95% 13.31 mg/L 13.79 mg/L 0.965192168237854 +DTXSID2045440 Css 3compartmentss Human 95% 0.5259 mg/L 8.557e-05 mg/L 6145.84550660278 +DTXSID2045442 Css 3compartmentss Human 95% 2.583 mg/L 1.476 mg/L 1.75 +DTXSID2045444 Css 3compartmentss Human 95% 0.9224 mg/L 0.464 mg/L 1.98793103448276 +DTXSID2045448 Css 3compartmentss Human 95% 26.53 mg/L 4.384 mg/L 6.05155109489051 +DTXSID2045490 Css 3compartmentss Human 95% 1.709 mg/L 30.31 mg/L 0.0563840316727153 +DTXSID2045492 Css 3compartmentss Human 95% 0.5358 mg/L 8.869 mg/L 0.0604126733566355 +DTXSID2045494 Css 3compartmentss Human 95% 0.8925 mg/L 0.445 mg/L 2.00561797752809 +DTXSID2045496 Css 3compartmentss Human 95% 4.153 mg/L 1.927 mg/L 2.15516346652828 +DTXSID2045498 Css 3compartmentss Human 95% 11.69 mg/L 2.049 mg/L 5.70522205954124 +DTXSID2045521 Css 3compartmentss Human 95% 2.006 mg/L 3.453 mg/L 0.580944106573994 +DTXSID2045523 Css 3compartmentss Human 95% 4.668 mg/L 5.532 mg/L 0.843817787418655 +DTXSID2045527 Css 3compartmentss Human 95% 8.249 mg/L 1.217 mg/L 6.77814297452753 +DTXSID2045529 Css 3compartmentss Human 95% 2.087 mg/L 15.69 mg/L 0.133014659018483 +DTXSID2045571 Css 3compartmentss Human 95% 6.377 mg/L 5.299 mg/L 1.20343461030383 +DTXSID2045573 Css 3compartmentss Human 95% 2.63 mg/L 32.36 mg/L 0.0812731767614339 +DTXSID2045575 Css 3compartmentss Human 95% 1.001 mg/L 0.3662 mg/L 2.73347897323867 +DTXSID2045579 Css 3compartmentss Human 95% 6.133 mg/L 17.64 mg/L 0.347675736961451 +DTXSID2045600 Css 3compartmentss Human 95% 0.414 mg/L 8.264 mg/L 0.0500968054211036 +DTXSID2045602 Css 3compartmentss Human 95% 9.735 mg/L 42.71 mg/L 0.227932568485132 +DTXSID2045606 Css 3compartmentss Human 95% 0.4185 mg/L 0.1514 mg/L 2.76420079260238 +DTXSID2045608 Css 3compartmentss Human 95% 1.256 mg/L 0.8378 mg/L 1.4991644783958 +DTXSID2045650 Css 3compartmentss Human 95% 5.27 mg/L 6.073 mg/L 0.867775399308414 +DTXSID2045652 Css 3compartmentss Human 95% 5.72 mg/L 0.515 mg/L 11.1067961165049 +DTXSID2045654 Css 3compartmentss Human 95% 8.089 mg/L 6.963 mg/L 1.16171190578774 +DTXSID2045656 Css 3compartmentss Human 95% 0.6061 mg/L 0.7319 mg/L 0.828118595436535 +DTXSID2045658 Css 3compartmentss Human 95% 6.105 mg/L 1.602 mg/L 3.81086142322097 +DTXSID2045781 Css 3compartmentss Human 95% 6.009 mg/L 1.035 mg/L 5.80579710144928 +DTXSID2045783 Css 3compartmentss Human 95% 6.758 mg/L 0.05451 mg/L 123.977251880389 +DTXSID2045785 Css 3compartmentss Human 95% 0.5882 mg/L 5.764 mg/L 0.10204718945177 +DTXSID2045787 Css 3compartmentss Human 95% 4.278 mg/L 5.223 mg/L 0.819069500287191 +DTXSID2045789 Css 3compartmentss Human 95% 6.576 mg/L 4.355 mg/L 1.50998851894374 +DTXSID2045810 Css 3compartmentss Human 95% 13.15 mg/L 5.327 mg/L 2.46855641073775 +DTXSID2045812 Css 3compartmentss Human 95% 1.239 mg/L 0.4147 mg/L 2.98770195321919 +DTXSID2045814 Css 3compartmentss Human 95% 1.095 mg/L 0.3359 mg/L 3.25989877939863 +DTXSID2045860 Css 3compartmentss Human 95% 2.83 mg/L 0.2082 mg/L 13.5926993275696 +DTXSID2045862 Css 3compartmentss Human 95% 1.093 mg/L 0.3035 mg/L 3.60131795716639 +DTXSID2045864 Css 3compartmentss Human 95% 1.25 mg/L 0.8173 mg/L 1.52942615930503 +DTXSID2045868 Css 3compartmentss Human 95% 0.9877 mg/L 4.813 mg/L 0.205215042592977 +DTXSID2045941 Css 3compartmentss Human 95% 10.81 mg/L 10.82 mg/L 0.999075785582255 +DTXSID2045943 Css 3compartmentss Human 95% 2.801 mg/L 12.02 mg/L 0.233028286189684 +DTXSID2045945 Css 3compartmentss Human 95% 1.305 mg/L 2.715 mg/L 0.480662983425414 +DTXSID2045993 Css 3compartmentss Human 95% 3.479 mg/L 4.607 mg/L 0.75515519861081 +DTXSID2046090 Css 3compartmentss Human 95% 0.9389 mg/L 0.2224 mg/L 4.2216726618705 +DTXSID2046092 Css 3compartmentss Human 95% 4.986 mg/L 13.77 mg/L 0.362091503267974 +DTXSID2046094 Css 3compartmentss Human 95% 7.272 mg/L 2.947 mg/L 2.46759416355616 +DTXSID2046096 Css 3compartmentss Human 95% 1.014 mg/L 0.1642 mg/L 6.17539585870889 +DTXSID2046121 Css 3compartmentss Human 95% 3.482 mg/L 1018 mg/L 0.00342043222003929 +DTXSID2046123 Css 3compartmentss Human 95% 1.654 mg/L 3.519 mg/L 0.470019892014777 +DTXSID2046127 Css 3compartmentss Human 95% 4.627 mg/L 5.344 mg/L 0.865830838323353 +DTXSID2046171 Css 3compartmentss Human 95% 3.175 mg/L 5.534 mg/L 0.573726057101554 +DTXSID2046173 Css 3compartmentss Human 95% 2.286 mg/L 2.798 mg/L 0.817012151536812 +DTXSID2046175 Css 3compartmentss Human 95% 16.1 mg/L 10.42 mg/L 1.54510556621881 +DTXSID2046177 Css 3compartmentss Human 95% 14.47 mg/L 35.4 mg/L 0.408757062146893 +DTXSID2046179 Css 3compartmentss Human 95% 1.721 mg/L 11.65 mg/L 0.147725321888412 +DTXSID2046200 Css 3compartmentss Human 95% 0.901 mg/L 0.1572 mg/L 5.73155216284987 +DTXSID2046202 Css 3compartmentss Human 95% 5.645 mg/L 7.839 mg/L 0.720117361908407 +DTXSID2046206 Css 3compartmentss Human 95% 1.005 mg/L 11.45 mg/L 0.0877729257641921 +DTXSID2046208 Css 3compartmentss Human 95% 1.445 mg/L 27.48 mg/L 0.0525836972343523 +DTXSID2046250 Css 3compartmentss Human 95% 6.552 mg/L 11.23 mg/L 0.583437221727516 +DTXSID2046252 Css 3compartmentss Human 95% 4.586 mg/L 6.54 mg/L 0.701223241590214 +DTXSID2046254 Css 3compartmentss Human 95% 17.57 mg/L NA NA NA +DTXSID2046256 Css 3compartmentss Human 95% 1.083 mg/L 1.228 mg/L 0.881921824104234 +DTXSID2046258 Css 3compartmentss Human 95% 1.175 mg/L 1.671 mg/L 0.703171753441053 +DTXSID2046383 Css 3compartmentss Human 95% 8.392 mg/L 0.1494 mg/L 56.1713520749665 +DTXSID2046385 Css 3compartmentss Human 95% 1.056 mg/L 0.1494 mg/L 7.06827309236948 +DTXSID2046389 Css 3compartmentss Human 95% 0.5623 mg/L 7.43 mg/L 0.0756796769851952 +DTXSID2046410 Css 3compartmentss Human 95% 5.589 mg/L 6.555 mg/L 0.852631578947369 +DTXSID2046412 Css 3compartmentss Human 95% 5.075 mg/L 5.58 mg/L 0.909498207885305 +DTXSID2046418 Css 3compartmentss Human 95% 5.098 mg/L 5.368 mg/L 0.949701937406855 +DTXSID2046460 Css 3compartmentss Human 95% 11.96 mg/L 20.15 mg/L 0.593548387096774 +DTXSID2046462 Css 3compartmentss Human 95% 4.311 mg/L 5.102 mg/L 0.844962759702078 +DTXSID2046464 Css 3compartmentss Human 95% 0.5309 mg/L 2.029 mg/L 0.261655988171513 +DTXSID2046468 Css 3compartmentss Human 95% 5.395 mg/L 3.263 mg/L 1.65338645418327 +DTXSID2046541 Css 3compartmentss Human 95% 11.89 mg/L 0.3371 mg/L 35.2714328092554 +DTXSID2046543 Css 3compartmentss Human 95% 0.3327 mg/L 5.997 mg/L 0.0554777388694347 +DTXSID2046545 Css 3compartmentss Human 95% 8.676 mg/L NA NA NA +DTXSID2046549 Css 3compartmentss Human 95% 7.714 mg/L 8.424 mg/L 0.915716999050332 +DTXSID2046591 Css 3compartmentss Human 95% 2.002 mg/L 9.48 mg/L 0.211181434599156 +DTXSID2046593 Css 3compartmentss Human 95% 0.008254 mg/L 0.001704 mg/L 4.84389671361502 +DTXSID2046597 Css 3compartmentss Human 95% 7.639 mg/L 8.135 mg/L 0.939028887523049 +DTXSID2046599 Css 3compartmentss Human 95% 1.078 mg/L 1.723 mg/L 0.625652930934417 +DTXSID2046624 Css 3compartmentss Human 95% 0.1928 mg/L 0.2358 mg/L 0.817642069550466 +DTXSID2046626 Css 3compartmentss Human 95% 3.034 mg/L 5.571 mg/L 0.544605995332974 +DTXSID2046628 Css 3compartmentss Human 95% 2.897 mg/L 0.3244 mg/L 8.93033292231812 +DTXSID2046670 Css 3compartmentss Human 95% 0.9494 mg/L 0.1618 mg/L 5.86773794808405 +DTXSID2046674 Css 3compartmentss Human 95% 8.136 mg/L 1.258 mg/L 6.46740858505564 +DTXSID2046678 Css 3compartmentss Human 95% 2.94 mg/L 5.23 mg/L 0.562141491395793 +DTXSID2046701 Css 3compartmentss Human 95% 1.003 mg/L 0.1099 mg/L 9.12647861692448 +DTXSID2046703 Css 3compartmentss Human 95% 8.624 mg/L 0.03754 mg/L 229.728289824188 +DTXSID2046705 Css 3compartmentss Human 95% 54.69 mg/L 163.8 mg/L 0.333882783882784 +DTXSID2046707 Css 3compartmentss Human 95% 2.691 mg/L 5.038 mg/L 0.534140531957126 +DTXSID2046709 Css 3compartmentss Human 95% 0.8832 mg/L 0.228 mg/L 3.87368421052632 +DTXSID2046751 Css 3compartmentss Human 95% 6.09 mg/L 0.3329 mg/L 18.2937819164914 +DTXSID2046755 Css 3compartmentss Human 95% 0.6591 mg/L 3.9 mg/L 0.169 +DTXSID2046759 Css 3compartmentss Human 95% 0.5999 mg/L 0.5923 mg/L 1.01283133547189 +DTXSID2046832 Css 3compartmentss Human 95% 0.7213 mg/L 1.898 mg/L 0.380031612223393 +DTXSID2046836 Css 3compartmentss Human 95% 7.406 mg/L 0.2107 mg/L 35.1495016611296 +DTXSID2046880 Css 3compartmentss Human 95% 2.901 mg/L 0.6325 mg/L 4.58656126482213 +DTXSID2046882 Css 3compartmentss Human 95% 4.968 mg/L 5.532 mg/L 0.898047722342733 +DTXSID2046886 Css 3compartmentss Human 95% 0.7923 mg/L 19.52 mg/L 0.0405891393442623 +DTXSID2046888 Css 3compartmentss Human 95% 2.364 mg/L 136 mg/L 0.0173823529411765 +DTXSID2046911 Css 3compartmentss Human 95% 0.9248 mg/L 0.5509 mg/L 1.67870756943184 +DTXSID2046913 Css 3compartmentss Human 95% 4.367 mg/L 2.45 mg/L 1.78244897959184 +DTXSID2046915 Css 3compartmentss Human 95% 5.296 mg/L 8.535 mg/L 0.620503807850029 +DTXSID2046919 Css 3compartmentss Human 95% 16.81 mg/L NA NA NA +DTXSID2047060 Css 3compartmentss Human 95% 0.611 mg/L 0.0577 mg/L 10.5892547660312 +DTXSID2047062 Css 3compartmentss Human 95% 0.302 mg/L 3.288 mg/L 0.0918491484184915 +DTXSID2047064 Css 3compartmentss Human 95% 0.5142 mg/L 27.67 mg/L 0.0185833032164799 +DTXSID2047066 Css 3compartmentss Human 95% 0.3627 mg/L 4.844 mg/L 0.0748761354252684 +DTXSID2047068 Css 3compartmentss Human 95% 5.876 mg/L NA NA NA +DTXSID2047145 Css 3compartmentss Human 95% 6.745 mg/L 7.83 mg/L 0.861430395913155 +DTXSID2047191 Css 3compartmentss Human 95% 20.69 mg/L 18.17 mg/L 1.13869014859659 +DTXSID2047193 Css 3compartmentss Human 95% 1.493 mg/L 5.43 mg/L 0.274953959484346 +DTXSID2047195 Css 3compartmentss Human 95% 3.618 mg/L 14.61 mg/L 0.247638603696099 +DTXSID2047199 Css 3compartmentss Human 95% 2.496 mg/L 2.471 mg/L 1.01011736139215 +DTXSID2047222 Css 3compartmentss Human 95% 17.42 mg/L 27.93 mg/L 0.623702112423917 +DTXSID2047270 Css 3compartmentss Human 95% 15.05 mg/L 14.43 mg/L 1.04296604296604 +DTXSID2047272 Css 3compartmentss Human 95% 10.99 mg/L 15.7 mg/L 0.7 +DTXSID2047274 Css 3compartmentss Human 95% 1.399 mg/L 32.47 mg/L 0.0430859254696643 +DTXSID2047276 Css 3compartmentss Human 95% 1.622 mg/L 0.04037 mg/L 40.1783502600941 +DTXSID2047278 Css 3compartmentss Human 95% 23.84 mg/L 6.363 mg/L 3.74666038032375 +DTXSID2047301 Css 3compartmentss Human 95% 1.241 mg/L 20.22 mg/L 0.0613748763600396 +DTXSID2047303 Css 3compartmentss Human 95% 9.513 mg/L 27.16 mg/L 0.350257731958763 +DTXSID2047305 Css 3compartmentss Human 95% 2.16 mg/L 4.485 mg/L 0.481605351170569 +DTXSID2047307 Css 3compartmentss Human 95% 111.7 mg/L 122.3 mg/L 0.913327882256746 +DTXSID2047309 Css 3compartmentss Human 95% 9.719 mg/L 559.9 mg/L 0.0173584568672977 +DTXSID2047351 Css 3compartmentss Human 95% 2.547 mg/L 0.05335 mg/L 47.7413308341143 +DTXSID2047353 Css 3compartmentss Human 95% 4.224 mg/L NA NA NA +DTXSID2047355 Css 3compartmentss Human 95% 13.1 mg/L 5.799 mg/L 2.25901017416796 +DTXSID2047357 Css 3compartmentss Human 95% 13240 mg/L 13700 mg/L 0.966423357664234 +DTXSID2047359 Css 3compartmentss Human 95% 0.4676 mg/L 1.728 mg/L 0.270601851851852 +DTXSID2047434 Css 3compartmentss Human 95% 7.271 mg/L 0.5394 mg/L 13.4797923618836 +DTXSID2047436 Css 3compartmentss Human 95% 7.136 mg/L 30.73 mg/L 0.232216075496258 +DTXSID2047567 Css 3compartmentss Human 95% 10.45 mg/L NA NA NA +DTXSID2047569 Css 3compartmentss Human 95% 5.473 mg/L 9.739 mg/L 0.561967347776979 +DTXSID2047646 Css 3compartmentss Human 95% 6.878 mg/L NA NA NA +DTXSID2047648 Css 3compartmentss Human 95% 1.556 mg/L NA NA NA +DTXSID2047694 Css 3compartmentss Human 95% 1.277 mg/L 1.623 mg/L 0.786814540973506 +DTXSID2047725 Css 3compartmentss Human 95% 16.77 mg/L 7.398 mg/L 2.26682887266829 +DTXSID2047727 Css 3compartmentss Human 95% 2.246 mg/L 1.118 mg/L 2.00894454382826 +DTXSID2047773 Css 3compartmentss Human 95% 0.4174 mg/L 3.095 mg/L 0.13486268174475 +DTXSID2047775 Css 3compartmentss Human 95% 1.153 mg/L 0.7654 mg/L 1.50640188136922 +DTXSID2047777 Css 3compartmentss Human 95% 3.775 mg/L 15.91 mg/L 0.237272155876807 +DTXSID2047779 Css 3compartmentss Human 95% 29.13 mg/L 10.25 mg/L 2.84195121951219 +DTXSID2047804 Css 3compartmentss Human 95% 1.549 mg/L 21.97 mg/L 0.0705052344105598 +DTXSID2047806 Css 3compartmentss Human 95% 5.316 mg/L NA NA NA +DTXSID2047850 Css 3compartmentss Human 95% 0.9701 mg/L 1.695 mg/L 0.572330383480826 +DTXSID2047852 Css 3compartmentss Human 95% 0.78 mg/L 1.742 mg/L 0.447761194029851 +DTXSID2047856 Css 3compartmentss Human 95% 0.7108 mg/L 1.226 mg/L 0.579771615008157 +DTXSID2047858 Css 3compartmentss Human 95% 3.559 mg/L 0.03626 mg/L 98.1522338665196 +DTXSID2048161 Css 3compartmentss Human 95% 0.4673 mg/L 0.8085 mg/L 0.577983920841064 +DTXSID2048169 Css 3compartmentss Human 95% 2.741 mg/L 13.41 mg/L 0.204399701715138 +DTXSID2048240 Css 3compartmentss Human 95% 2.645 mg/L NA NA NA +DTXSID2048244 Css 3compartmentss Human 95% 1.866 mg/L NA NA NA +DTXSID2048290 Css 3compartmentss Human 95% 4.878 mg/L NA NA NA +DTXSID2048321 Css 3compartmentss Human 95% 1.935 mg/L NA NA NA +DTXSID2048329 Css 3compartmentss Human 95% 8.91 mg/L NA NA NA +DTXSID2048379 Css 3compartmentss Human 95% 1.662 mg/L 2.896 mg/L 0.573895027624309 +DTXSID2048535 Css 3compartmentss Human 95% 1.184 mg/L NA NA NA +DTXSID2048539 Css 3compartmentss Human 95% 1.256 mg/L 0.8563 mg/L 1.46677566273502 +DTXSID2048581 Css 3compartmentss Human 95% 8.135 mg/L 14.21 mg/L 0.572484166080225 +DTXSID2048583 Css 3compartmentss Human 95% 0.7397 mg/L 12.85 mg/L 0.0575642023346304 +DTXSID2048587 Css 3compartmentss Human 95% 8.554 mg/L 7.38 mg/L 1.15907859078591 +DTXSID2048589 Css 3compartmentss Human 95% 2.274 mg/L 2.702 mg/L 0.84159881569208 +DTXSID2048610 Css 3compartmentss Human 95% 40.88 mg/L 20.76 mg/L 1.96917148362235 +DTXSID2048612 Css 3compartmentss Human 95% 1.536 mg/L 3.344 mg/L 0.45933014354067 +DTXSID2048614 Css 3compartmentss Human 95% 2.559 mg/L 3.624 mg/L 0.70612582781457 +DTXSID2048616 Css 3compartmentss Human 95% 5.811 mg/L 6.561 mg/L 0.885688157293096 +DTXSID2048618 Css 3compartmentss Human 95% 0.9025 mg/L 10.34 mg/L 0.0872823984526112 +DTXSID2048660 Css 3compartmentss Human 95% 1.198 mg/L 45.67 mg/L 0.0262316619224874 +DTXSID2048662 Css 3compartmentss Human 95% 0.01464 mg/L 0.4179 mg/L 0.0350323043790381 +DTXSID2048664 Css 3compartmentss Human 95% 4.025 mg/L 0.7329 mg/L 5.49188156638013 +DTXSID2048666 Css 3compartmentss Human 95% 8.098 mg/L 30.58 mg/L 0.264813603662525 +DTXSID2048668 Css 3compartmentss Human 95% 10.01 mg/L 2.808 mg/L 3.56481481481481 +DTXSID2048741 Css 3compartmentss Human 95% 7.403 mg/L 8.699 mg/L 0.851017358317048 +DTXSID2048743 Css 3compartmentss Human 95% 1.251 mg/L 2.346 mg/L 0.533248081841432 +DTXSID2048745 Css 3compartmentss Human 95% 18.33 mg/L 1.741 mg/L 10.5284319356692 +DTXSID2048747 Css 3compartmentss Human 95% 0.2764 mg/L 4.655 mg/L 0.0593770139634801 +DTXSID2048749 Css 3compartmentss Human 95% 1.315 mg/L 0.1601 mg/L 8.21361648969394 +DTXSID2048791 Css 3compartmentss Human 95% 5.051 mg/L 0.1834 mg/L 27.5408942202835 +DTXSID2048793 Css 3compartmentss Human 95% 1.751 mg/L 0.2123 mg/L 8.24776260009421 +DTXSID2048795 Css 3compartmentss Human 95% 3.268 mg/L 79.02 mg/L 0.0413566185775753 +DTXSID2048799 Css 3compartmentss Human 95% 4.314 mg/L 7.631 mg/L 0.565325645393788 +DTXSID2048820 Css 3compartmentss Human 95% 1.787 mg/L 14.12 mg/L 0.126558073654391 +DTXSID2048822 Css 3compartmentss Human 95% 1.283 mg/L 21.25 mg/L 0.0603764705882353 +DTXSID2048826 Css 3compartmentss Human 95% 4.253 mg/L 25.02 mg/L 0.169984012789768 +DTXSID2048828 Css 3compartmentss Human 95% 1.374 mg/L 4.951 mg/L 0.277519692991315 +DTXSID2048870 Css 3compartmentss Human 95% 1.066 mg/L 0.185 mg/L 5.76216216216216 +DTXSID2048872 Css 3compartmentss Human 95% 1.231 mg/L 0.6371 mg/L 1.93219274839115 +DTXSID2048874 Css 3compartmentss Human 95% 7.853 mg/L 11.41 mg/L 0.688255915863278 +DTXSID2048876 Css 3compartmentss Human 95% 0.913 mg/L 0.696 mg/L 1.3117816091954 +DTXSID2048878 Css 3compartmentss Human 95% 0.4677 mg/L 0.05503 mg/L 8.49900054515719 +DTXSID2048901 Css 3compartmentss Human 95% 0.3213 mg/L 0.3231 mg/L 0.994428969359331 +DTXSID2048903 Css 3compartmentss Human 95% 1.03 mg/L 0.4085 mg/L 2.52141982864137 +DTXSID2048905 Css 3compartmentss Human 95% 19.54 mg/L 6.787 mg/L 2.87903344629439 +DTXSID2048907 Css 3compartmentss Human 95% 0.9012 mg/L 0.2812 mg/L 3.20483641536273 +DTXSID2048909 Css 3compartmentss Human 95% 0.7337 mg/L 1.095 mg/L 0.670045662100457 +DTXSID2048953 Css 3compartmentss Human 95% 9.981 mg/L 15.94 mg/L 0.626160602258469 +DTXSID2048955 Css 3compartmentss Human 95% 1.804 mg/L 17.05 mg/L 0.105806451612903 +DTXSID2048957 Css 3compartmentss Human 95% 4.919 mg/L 4.372 mg/L 1.12511436413541 +DTXSID2048959 Css 3compartmentss Human 95% 1.949 mg/L 5.695 mg/L 0.342230026338894 +DTXSID2049000 Css 3compartmentss Human 95% 25.4 mg/L 43.55 mg/L 0.583237657864524 +DTXSID2049002 Css 3compartmentss Human 95% 2.504 mg/L 70.35 mg/L 0.0355934612651031 +DTXSID2049004 Css 3compartmentss Human 95% 3.108 mg/L 5.459 mg/L 0.569335043048177 +DTXSID2049006 Css 3compartmentss Human 95% 7.994 mg/L 3.713 mg/L 2.15297603016429 +DTXSID2049050 Css 3compartmentss Human 95% 2.69 mg/L 0.9099 mg/L 2.95636883173975 +DTXSID2049052 Css 3compartmentss Human 95% 1.378 mg/L 0.6899 mg/L 1.99739092622119 +DTXSID2049054 Css 3compartmentss Human 95% 2.075 mg/L 25.51 mg/L 0.0813406507252058 +DTXSID2049056 Css 3compartmentss Human 95% 1.794 mg/L 1.401 mg/L 1.28051391862955 +DTXSID2049058 Css 3compartmentss Human 95% 7.983 mg/L 1.042 mg/L 7.66122840690979 +DTXSID2049135 Css 3compartmentss Human 95% 1.73 mg/L 12.85 mg/L 0.134630350194553 +DTXSID2049210 Css 3compartmentss Human 95% 7.177 mg/L 13.71 mg/L 0.523486506199854 +DTXSID2049260 Css 3compartmentss Human 95% 27.35 mg/L 18.12 mg/L 1.50938189845475 +DTXSID2049262 Css 3compartmentss Human 95% 0.3625 mg/L 0.9885 mg/L 0.366717248356095 +DTXSID2049268 Css 3compartmentss Human 95% 2.056 mg/L 49.22 mg/L 0.0417716375457131 +DTXSID2049393 Css 3compartmentss Human 95% 12.19 mg/L 2.395 mg/L 5.08977035490605 +DTXSID2049397 Css 3compartmentss Human 95% 12.36 mg/L 1.19 mg/L 10.3865546218487 +DTXSID2049399 Css 3compartmentss Human 95% 6.958 mg/L 5.464 mg/L 1.27342606149341 +DTXSID2049420 Css 3compartmentss Human 95% 0.3787 mg/L 4.322 mg/L 0.0876214715409533 +DTXSID2049422 Css 3compartmentss Human 95% 0.791 mg/L 0.2956 mg/L 2.67591339648173 +DTXSID2049424 Css 3compartmentss Human 95% 0.2963 mg/L 3.592 mg/L 0.082488864142539 +DTXSID2049426 Css 3compartmentss Human 95% 1.099 mg/L 5.573 mg/L 0.197200789520904 +DTXSID2049428 Css 3compartmentss Human 95% 0.5263 mg/L 5.902 mg/L 0.089173161640122 +DTXSID2051631 Css 3compartmentss Human 95% 8.01 mg/L 0.1454 mg/L 55.0894085281981 +DTXSID2051687 Css 3compartmentss Human 95% 23.06 mg/L 8.154 mg/L 2.8280598479274 +DTXSID2051710 Css 3compartmentss Human 95% 3.594 mg/L NA NA NA +DTXSID2051716 Css 3compartmentss Human 95% 3.839 mg/L 4.747 mg/L 0.808721297661681 +DTXSID2051764 Css 3compartmentss Human 95% 0.372 mg/L NA NA NA +DTXSID2051895 Css 3compartmentss Human 95% 3.399 mg/L NA NA NA +DTXSID2052108 Css 3compartmentss Human 95% 0.2794 mg/L NA NA NA +DTXSID2052281 Css 3compartmentss Human 95% 6.157 mg/L 4.943 mg/L 1.24559983815497 +DTXSID2052283 Css 3compartmentss Human 95% 0.3021 mg/L 5.433 mg/L 0.0556046383213694 +DTXSID2052289 Css 3compartmentss Human 95% 2.936 mg/L 4.131 mg/L 0.710723795691116 +DTXSID2052310 Css 3compartmentss Human 95% 1.433 mg/L 1.665 mg/L 0.860660660660661 +DTXSID2052441 Css 3compartmentss Human 95% 7.104 mg/L NA NA NA +DTXSID2052491 Css 3compartmentss Human 95% 6.391 mg/L NA NA NA +DTXSID2052493 Css 3compartmentss Human 95% 7.556 mg/L NA NA NA +DTXSID2052574 Css 3compartmentss Human 95% 1.622 mg/L 2.19 mg/L 0.740639269406393 +DTXSID2052578 Css 3compartmentss Human 95% 11.46 mg/L NA NA NA +DTXSID2052603 Css 3compartmentss Human 95% 24.6 mg/L 29.56 mg/L 0.832205683355886 +DTXSID2052607 Css 3compartmentss Human 95% 0.3871 mg/L 0.155 mg/L 2.49741935483871 +DTXSID2052655 Css 3compartmentss Human 95% 4.075 mg/L NA NA NA +DTXSID2052734 Css 3compartmentss Human 95% 1.788 mg/L NA NA NA +DTXSID2052738 Css 3compartmentss Human 95% 0.5269 mg/L NA NA NA +DTXSID2057576 Css 3compartmentss Human 95% 0.8835 mg/L NA NA NA +DTXSID2057601 Css 3compartmentss Human 95% 1.701 mg/L 17.22 mg/L 0.0987804878048781 +DTXSID2057603 Css 3compartmentss Human 95% 0.8802 mg/L 0.4236 mg/L 2.07790368271955 +DTXSID2057609 Css 3compartmentss Human 95% 0.9768 mg/L 2.8 mg/L 0.348857142857143 +DTXSID2057651 Css 3compartmentss Human 95% 13.26 mg/L 2.355 mg/L 5.63057324840764 +DTXSID2057653 Css 3compartmentss Human 95% 2.73 mg/L 3.448 mg/L 0.791763341067285 +DTXSID2057655 Css 3compartmentss Human 95% 0.8866 mg/L 0.4743 mg/L 1.86928104575163 +DTXSID2057657 Css 3compartmentss Human 95% 1.055 mg/L 0.8856 mg/L 1.19128274616079 +DTXSID2057659 Css 3compartmentss Human 95% 3.404 mg/L 5.851 mg/L 0.581780892155187 +DTXSID2057730 Css 3compartmentss Human 95% 9.389 mg/L 0.722 mg/L 13.0041551246537 +DTXSID2057732 Css 3compartmentss Human 95% 0.4587 mg/L 2.208 mg/L 0.207744565217391 +DTXSID2057734 Css 3compartmentss Human 95% 0.4277 mg/L 0.3452 mg/L 1.23899188876014 +DTXSID2057736 Css 3compartmentss Human 95% 0.4293 mg/L 2.627 mg/L 0.16341834792539 +DTXSID2057738 Css 3compartmentss Human 95% 6.474 mg/L 0.9982 mg/L 6.48567421358445 +DTXSID2057782 Css 3compartmentss Human 95% 2.01 mg/L 5.765 mg/L 0.348655680832611 +DTXSID2057784 Css 3compartmentss Human 95% 0.3657 mg/L 0.3219 mg/L 1.13606710158434 +DTXSID2057811 Css 3compartmentss Human 95% 7.168 mg/L 8.797 mg/L 0.814823235193816 +DTXSID2057813 Css 3compartmentss Human 95% 1.007 mg/L 0.5745 mg/L 1.75282854656223 +DTXSID2057815 Css 3compartmentss Human 95% 5.154 mg/L 35.42 mg/L 0.145511010728402 +DTXSID2057817 Css 3compartmentss Human 95% 1.353 mg/L 2.269 mg/L 0.596297928602909 +DTXSID2057819 Css 3compartmentss Human 95% 0.9609 mg/L 1.434 mg/L 0.670083682008368 +DTXSID2057865 Css 3compartmentss Human 95% 0.3349 mg/L NA NA NA +DTXSID2058251 Css 3compartmentss Human 95% 18.76 mg/L NA NA NA +DTXSID2058621 Css 3compartmentss Human 95% 5.366 mg/L NA NA NA +DTXSID2058629 Css 3compartmentss Human 95% 6.356 mg/L NA NA NA +DTXSID2059015 Css 3compartmentss Human 95% 2.621 mg/L NA NA NA +DTXSID2059192 Css 3compartmentss Human 95% 14.51 mg/L NA NA NA +DTXSID2060173 Css 3compartmentss Human 95% 0.7908 mg/L NA NA NA +DTXSID2060416 Css 3compartmentss Human 95% 1.136 mg/L NA NA NA +DTXSID2060549 Css 3compartmentss Human 95% 8.294 mg/L NA NA NA +DTXSID2060753 Css 3compartmentss Human 95% 1.557 mg/L NA NA NA +DTXSID2064733 Css 3compartmentss Human 95% 0.3394 mg/L NA NA NA +DTXSID20648089 Css 3compartmentss Human 95% 2.181 mg/L NA NA NA +DTXSID20859299 Css 3compartmentss Human 95% 98.16 mg/L NA NA NA +DTXSID20861271 Css 3compartmentss Human 95% 9.409 mg/L NA NA NA +DTXSID20862021 Css 3compartmentss Human 95% 9.783 mg/L NA NA NA +DTXSID20862324 Css 3compartmentss Human 95% 12.1 mg/L NA NA NA +DTXSID20862889 Css 3compartmentss Human 95% 0.4942 mg/L NA NA NA +DTXSID20863674 Css 3compartmentss Human 95% 17.72 mg/L NA NA NA +DTXSID20864287 Css 3compartmentss Human 95% 18.09 mg/L NA NA NA +DTXSID20868982 Css 3compartmentss Human 95% 4.749 mg/L NA NA NA +DTXSID20869010 Css 3compartmentss Human 95% 6.704 mg/L NA NA NA +DTXSID20869373 Css 3compartmentss Human 95% 0.6959 mg/L NA NA NA +DTXSID20869939 Css 3compartmentss Human 95% 2.919 mg/L NA NA NA +DTXSID20873213 Css 3compartmentss Human 95% 0.8344 mg/L NA NA NA +DTXSID20873334 Css 3compartmentss Human 95% 6.726 mg/L NA NA NA +DTXSID20879477 Css 3compartmentss Human 95% 0.3995 mg/L NA NA NA +DTXSID20880629 Css 3compartmentss Human 95% 7.969 mg/L NA NA NA +DTXSID20880684 Css 3compartmentss Human 95% 1.645 mg/L NA NA NA +DTXSID20880740 Css 3compartmentss Human 95% 11.56 mg/L NA NA NA +DTXSID20880780 Css 3compartmentss Human 95% 0.2234 mg/L NA NA NA +DTXSID20880826 Css 3compartmentss Human 95% 12.93 mg/L NA NA NA +DTXSID20880902 Css 3compartmentss Human 95% 15.98 mg/L NA NA NA +DTXSID20880907 Css 3compartmentss Human 95% 11.77 mg/L NA NA NA +DTXSID20880922 Css 3compartmentss Human 95% 0.9486 mg/L NA NA NA +DTXSID20881237 Css 3compartmentss Human 95% 20.73 mg/L NA NA NA +DTXSID20881252 Css 3compartmentss Human 95% 6.231 mg/L NA NA NA +DTXSID20904894 Css 3compartmentss Human 95% 5.616 mg/L NA NA NA +DTXSID20904970 Css 3compartmentss Human 95% 8.573 mg/L NA NA NA +DTXSID20905104 Css 3compartmentss Human 95% 6.421 mg/L NA NA NA +DTXSID20926399 Css 3compartmentss Human 95% 5.789 mg/L NA NA NA +DTXSID20953024 Css 3compartmentss Human 95% 0.2676 mg/L NA NA NA +DTXSID20963461 Css 3compartmentss Human 95% 0.774 mg/L NA NA NA +DTXSID20964175 Css 3compartmentss Human 95% 0.7014 mg/L NA NA NA +DTXSID20966639 Css 3compartmentss Human 95% 18 mg/L NA NA NA +DTXSID301014178 Css 3compartmentss Human 95% 0.213 mg/L NA NA NA +DTXSID301029850 Css 3compartmentss Human 95% 2.178 mg/L NA NA NA +DTXSID30152026 Css 3compartmentss Human 95% 3.755 mg/L NA NA NA +DTXSID30153230 Css 3compartmentss Human 95% 26.62 mg/L NA NA NA +DTXSID30153457 Css 3compartmentss Human 95% 20.57 mg/L NA NA NA +DTXSID30166042 Css 3compartmentss Human 95% 1.08 mg/L NA NA NA +DTXSID30166683 Css 3compartmentss Human 95% 6.208 mg/L 10.24 mg/L 0.60625 +DTXSID30166724 Css 3compartmentss Human 95% 0.1991 mg/L NA NA NA +DTXSID30173135 Css 3compartmentss Human 95% 1.796 mg/L NA NA NA +DTXSID30184983 Css 3compartmentss Human 95% 0.7418 mg/L NA NA NA +DTXSID30187611 Css 3compartmentss Human 95% 2.28 mg/L NA NA NA +DTXSID30199936 Css 3compartmentss Human 95% 7.914 mg/L NA NA NA +DTXSID3020043 Css 3compartmentss Human 95% 5.235 mg/L 5.728 mg/L 0.91393156424581 +DTXSID3020091 Css 3compartmentss Human 95% 1.137 mg/L 0.9464 mg/L 1.20139475908707 +DTXSID3020093 Css 3compartmentss Human 95% 0.4349 mg/L 0.1034 mg/L 4.20599613152805 +DTXSID3020095 Css 3compartmentss Human 95% 3.718 mg/L 10.61 mg/L 0.350424128180961 +DTXSID3020097 Css 3compartmentss Human 95% 17.32 mg/L 0.5823 mg/L 29.7441181521552 +DTXSID3020099 Css 3compartmentss Human 95% 2.784 mg/L 8.016 mg/L 0.347305389221557 +DTXSID3020120 Css 3compartmentss Human 95% 15.82 mg/L 1.45 mg/L 10.9103448275862 +DTXSID3020122 Css 3compartmentss Human 95% 0.684 mg/L 0.7085 mg/L 0.965419901199718 +DTXSID3020128 Css 3compartmentss Human 95% 6.014 mg/L 6.205 mg/L 0.969218372280419 +DTXSID3020207 Css 3compartmentss Human 95% 10300 mg/L 10670 mg/L 0.965323336457357 +DTXSID3020209 Css 3compartmentss Human 95% 3.053 mg/L 3.238 mg/L 0.942865966646078 +DTXSID3020253 Css 3compartmentss Human 95% 0.7745 mg/L 0.002773 mg/L 279.300396682294 +DTXSID3020257 Css 3compartmentss Human 95% 5.093 mg/L 5.287 mg/L 0.963306222810668 +DTXSID3020330 Css 3compartmentss Human 95% 5.181 mg/L 6.252 mg/L 0.828694817658349 +DTXSID3020332 Css 3compartmentss Human 95% 5.162 mg/L 5.842 mg/L 0.883601506333447 +DTXSID3020336 Css 3compartmentss Human 95% 0.8546 mg/L 0.8458 mg/L 1.01040435091038 +DTXSID3020380 Css 3compartmentss Human 95% 17.06 mg/L 3.224 mg/L 5.29156327543424 +DTXSID3020384 Css 3compartmentss Human 95% 2.072 mg/L 2.712 mg/L 0.76401179941003 +DTXSID3020463 Css 3compartmentss Human 95% 5.032 mg/L 1.075 mg/L 4.68093023255814 +DTXSID3020465 Css 3compartmentss Human 95% 6.175 mg/L 6.226 mg/L 0.991808544812078 +DTXSID3020469 Css 3compartmentss Human 95% 0.9244 mg/L 1.338 mg/L 0.690881913303438 +DTXSID3020540 Css 3compartmentss Human 95% 11.85 mg/L 2.795 mg/L 4.2397137745975 +DTXSID3020546 Css 3compartmentss Human 95% 1.842 mg/L 2.183 mg/L 0.843792945487861 +DTXSID3020548 Css 3compartmentss Human 95% 10.94 mg/L NA NA NA +DTXSID3020598 Css 3compartmentss Human 95% 2.789 mg/L 3.292 mg/L 0.847205346294046 +DTXSID3020621 Css 3compartmentss Human 95% 517.8 mg/L 482.8 mg/L 1.07249378624689 +DTXSID3020625 Css 3compartmentss Human 95% 10.14 mg/L 8.079 mg/L 1.25510582992945 +DTXSID3020627 Css 3compartmentss Human 95% 1.167 mg/L 1.648 mg/L 0.708131067961165 +DTXSID3020629 Css 3compartmentss Human 95% 38.72 mg/L 58.39 mg/L 0.663127247816407 +DTXSID3020671 Css 3compartmentss Human 95% 3.371 mg/L 65.91 mg/L 0.0511455014413594 +DTXSID3020673 Css 3compartmentss Human 95% 203.5 mg/L 257.9 mg/L 0.789065529274913 +DTXSID3020700 Css 3compartmentss Human 95% 5.007 mg/L 5.584 mg/L 0.896669054441261 +DTXSID3020704 Css 3compartmentss Human 95% 0.692 mg/L 0.2886 mg/L 2.3977823977824 +DTXSID3020706 Css 3compartmentss Human 95% 8.514 mg/L 0.5834 mg/L 14.5937607130614 +DTXSID3020708 Css 3compartmentss Human 95% 0.3637 mg/L 11.62 mg/L 0.0312994836488812 +DTXSID3020750 Css 3compartmentss Human 95% 4.341 mg/L 4.977 mg/L 0.872212176009644 +DTXSID3020754 Css 3compartmentss Human 95% 0.9504 mg/L NA NA NA +DTXSID3020756 Css 3compartmentss Human 95% 6.799 mg/L 1.763 mg/L 3.85649461145774 +DTXSID3020835 Css 3compartmentss Human 95% 2.822 mg/L 3.311 mg/L 0.852310480217457 +DTXSID3020881 Css 3compartmentss Human 95% 0.3915 mg/L 0.4353 mg/L 0.899379738111647 +DTXSID3020885 Css 3compartmentss Human 95% 4.525 mg/L NA NA NA +DTXSID3020910 Css 3compartmentss Human 95% 1.748 mg/L 1.908 mg/L 0.916142557651992 +DTXSID3020912 Css 3compartmentss Human 95% 2.334 mg/L 2.307 mg/L 1.01170351105332 +DTXSID3020914 Css 3compartmentss Human 95% 9.823 mg/L 2.374 mg/L 4.13774220724516 +DTXSID3020916 Css 3compartmentss Human 95% 7.499 mg/L 7.598 mg/L 0.98697025533035 +DTXSID3020918 Css 3compartmentss Human 95% 42.85 mg/L 4.411 mg/L 9.71435048741782 +DTXSID3020960 Css 3compartmentss Human 95% 10.13 mg/L 14.48 mg/L 0.699585635359116 +DTXSID3020962 Css 3compartmentss Human 95% 0.5849 mg/L 0.374 mg/L 1.56390374331551 +DTXSID3020964 Css 3compartmentss Human 95% 0.9226 mg/L 0.953 mg/L 0.96810073452256 +DTXSID3020966 Css 3compartmentss Human 95% 27.03 mg/L 28.5 mg/L 0.948421052631579 +DTXSID3021065 Css 3compartmentss Human 95% 0.6702 mg/L 1.025 mg/L 0.653853658536585 +DTXSID3021069 Css 3compartmentss Human 95% 2.131 mg/L 1.65 mg/L 1.29151515151515 +DTXSID30210695 Css 3compartmentss Human 95% 16.58 mg/L NA NA NA +DTXSID3021140 Css 3compartmentss Human 95% 7.914 mg/L 0.1977 mg/L 40.0303490136571 +DTXSID3021142 Css 3compartmentss Human 95% 6.241 mg/L 0.1714 mg/L 36.4119019836639 +DTXSID3021144 Css 3compartmentss Human 95% 0.9774 mg/L 0.4862 mg/L 2.01028383381325 +DTXSID3021148 Css 3compartmentss Human 95% 0.3925 mg/L 0.4211 mg/L 0.932082640702921 +DTXSID3021190 Css 3compartmentss Human 95% 0.842 mg/L 0.1674 mg/L 5.02986857825567 +DTXSID3021192 Css 3compartmentss Human 95% 3.019 mg/L 38.07 mg/L 0.0793012871027056 +DTXSID3021196 Css 3compartmentss Human 95% 10.05 mg/L 10.2 mg/L 0.985294117647059 +DTXSID3021198 Css 3compartmentss Human 95% 6.337 mg/L 0.07077 mg/L 89.5435919174791 +DTXSID3021221 Css 3compartmentss Human 95% 0.8671 mg/L 53.44 mg/L 0.0162256736526946 +DTXSID3021223 Css 3compartmentss Human 95% 1.848 mg/L 1.122 mg/L 1.64705882352941 +DTXSID3021225 Css 3compartmentss Human 95% 3.106 mg/L NA NA NA +DTXSID3021229 Css 3compartmentss Human 95% 3.14 mg/L NA NA NA +DTXSID3021275 Css 3compartmentss Human 95% 7.449 mg/L 2.559 mg/L 2.91090269636577 +DTXSID3021277 Css 3compartmentss Human 95% 6.418 mg/L 6.933 mg/L 0.925717582576085 +DTXSID3021304 Css 3compartmentss Human 95% 5.059 mg/L 5.542 mg/L 0.912847347527968 +DTXSID3021358 Css 3compartmentss Human 95% 37.32 mg/L 37.66 mg/L 0.990971853425385 +DTXSID30213984 Css 3compartmentss Human 95% 4.897 mg/L NA NA NA +DTXSID3021483 Css 3compartmentss Human 95% 0.5076 mg/L 1.463 mg/L 0.346958304853042 +DTXSID3021485 Css 3compartmentss Human 95% 15.45 mg/L 16.05 mg/L 0.962616822429906 +DTXSID3021487 Css 3compartmentss Human 95% 7.493 mg/L 11.88 mg/L 0.630723905723906 +DTXSID3021518 Css 3compartmentss Human 95% 7.63 mg/L 8.733 mg/L 0.87369746936906 +DTXSID30215640 Css 3compartmentss Human 95% 4.975 mg/L NA NA NA +DTXSID3021641 Css 3compartmentss Human 95% 1.291 mg/L 18.11 mg/L 0.0712865819988956 +DTXSID3021647 Css 3compartmentss Human 95% 4.986 mg/L 8.246 mg/L 0.604656803298569 +DTXSID3021726 Css 3compartmentss Human 95% 0.4643 mg/L 2.537 mg/L 0.183011430823808 +DTXSID3021770 Css 3compartmentss Human 95% 18.36 mg/L 8.756 mg/L 2.09684787574235 +DTXSID3021772 Css 3compartmentss Human 95% 6.428 mg/L 7.749 mg/L 0.829526390502 +DTXSID3021778 Css 3compartmentss Human 95% 1.903 mg/L 0.6144 mg/L 3.09733072916667 +DTXSID3021801 Css 3compartmentss Human 95% 0.4295 mg/L 1.385 mg/L 0.310108303249097 +DTXSID3021803 Css 3compartmentss Human 95% 0.6388 mg/L 4.728 mg/L 0.135109983079526 +DTXSID3021805 Css 3compartmentss Human 95% 3.58 mg/L 0.375 mg/L 9.54666666666667 +DTXSID3021851 Css 3compartmentss Human 95% 0.7644 mg/L 3.173 mg/L 0.240907658367476 +DTXSID3021853 Css 3compartmentss Human 95% 3.938 mg/L 3.75 mg/L 1.05013333333333 +DTXSID3021930 Css 3compartmentss Human 95% 5.552 mg/L 1.214 mg/L 4.57331136738056 +DTXSID3021932 Css 3compartmentss Human 95% 2 mg/L 2.353 mg/L 0.849978750531237 +DTXSID3021936 Css 3compartmentss Human 95% 7.367 mg/L 5.012 mg/L 1.46987230646449 +DTXSID3021986 Css 3compartmentss Human 95% 271.1 mg/L 271.1 mg/L 1 +DTXSID3022035 Css 3compartmentss Human 95% 1.333 mg/L 27.38 mg/L 0.0486851716581446 +DTXSID3022085 Css 3compartmentss Human 95% 0.7109 mg/L 0.08717 mg/L 8.15532866811977 +DTXSID3022089 Css 3compartmentss Human 95% 0.4168 mg/L 3.459 mg/L 0.120497253541486 +DTXSID3022114 Css 3compartmentss Human 95% 0.3223 mg/L NA NA NA +DTXSID3022160 Css 3compartmentss Human 95% 14.36 mg/L 13.26 mg/L 1.08295625942685 +DTXSID3022162 Css 3compartmentss Human 95% 0.4136 mg/L 0.4169 mg/L 0.992084432717678 +DTXSID3022164 Css 3compartmentss Human 95% 1.102 mg/L 2.061 mg/L 0.534691897137312 +DTXSID3022247 Css 3compartmentss Human 95% 13.53 mg/L 4.442 mg/L 3.04592525889239 +DTXSID3022295 Css 3compartmentss Human 95% 1.34 mg/L NA NA NA +DTXSID3022320 Css 3compartmentss Human 95% 23.45 mg/L 12.49 mg/L 1.87750200160128 +DTXSID3022326 Css 3compartmentss Human 95% 12.34 mg/L 10.44 mg/L 1.18199233716475 +DTXSID3022328 Css 3compartmentss Human 95% 16.01 mg/L NA NA NA +DTXSID3022370 Css 3compartmentss Human 95% 7.291 mg/L 7.116 mg/L 1.02459246767847 +DTXSID3022401 Css 3compartmentss Human 95% 0.4517 mg/L 0.03882 mg/L 11.6357547655847 +DTXSID3022403 Css 3compartmentss Human 95% 2.798 mg/L 1.617 mg/L 1.73036487322202 +DTXSID3022405 Css 3compartmentss Human 95% 14.7 mg/L 15.51 mg/L 0.947775628626692 +DTXSID3022409 Css 3compartmentss Human 95% 55.78 mg/L 58.14 mg/L 0.959408324733402 +DTXSID3022455 Css 3compartmentss Human 95% 7.488 mg/L 7.659 mg/L 0.977673325499413 +DTXSID3022536 Css 3compartmentss Human 95% 5.757 mg/L 5.603 mg/L 1.02748527574514 +DTXSID3022582 Css 3compartmentss Human 95% 5.23 mg/L 57.66 mg/L 0.0907041276448144 +DTXSID3022584 Css 3compartmentss Human 95% 3.384 mg/L 1.069 mg/L 3.16557530402245 +DTXSID3022586 Css 3compartmentss Human 95% 4.42 mg/L 5.092 mg/L 0.86802827965436 +DTXSID3022588 Css 3compartmentss Human 95% 3.685 mg/L 6.255 mg/L 0.589128697042366 +DTXSID30225901 Css 3compartmentss Human 95% 7.359 mg/L NA NA NA +DTXSID3022611 Css 3compartmentss Human 95% 4.476 mg/L 315.1 mg/L 0.0142050142811806 +DTXSID3022613 Css 3compartmentss Human 95% 0.3196 mg/L NA NA NA +DTXSID3022617 Css 3compartmentss Human 95% 5.709 mg/L 2.676 mg/L 2.13340807174888 +DTXSID3022663 Css 3compartmentss Human 95% 423.1 mg/L 450.8 mg/L 0.938553682342502 +DTXSID3022667 Css 3compartmentss Human 95% 8.738 mg/L 1.752 mg/L 4.98744292237443 +DTXSID3022742 Css 3compartmentss Human 95% 10.64 mg/L 9.257 mg/L 1.14940045371071 +DTXSID3022748 Css 3compartmentss Human 95% 5.03 mg/L 4.44 mg/L 1.13288288288288 +DTXSID3022796 Css 3compartmentss Human 95% 2.976 mg/L 14.08 mg/L 0.211363636363636 +DTXSID3022798 Css 3compartmentss Human 95% 2.157 mg/L 11.29 mg/L 0.191054030115146 +DTXSID3022821 Css 3compartmentss Human 95% 2.318 mg/L 1.022 mg/L 2.26810176125245 +DTXSID3022825 Css 3compartmentss Human 95% 33.76 mg/L 6.68 mg/L 5.05389221556886 +DTXSID3022829 Css 3compartmentss Human 95% 8.426 mg/L 1.045 mg/L 8.06315789473684 +DTXSID3022871 Css 3compartmentss Human 95% 1.196 mg/L 11.96 mg/L 0.1 +DTXSID3022873 Css 3compartmentss Human 95% 2.869 mg/L 17.4 mg/L 0.164885057471264 +DTXSID3022875 Css 3compartmentss Human 95% 5.76 mg/L 6.966 mg/L 0.82687338501292 +DTXSID3022877 Css 3compartmentss Human 95% 0.129 mg/L 5.411 mg/L 0.0238403252633524 +DTXSID3022902 Css 3compartmentss Human 95% 4.152 mg/L 15.53 mg/L 0.267353509336768 +DTXSID3022904 Css 3compartmentss Human 95% 2.267 mg/L 6.052 mg/L 0.374586913417052 +DTXSID3022906 Css 3compartmentss Human 95% 4.494 mg/L 5.267 mg/L 0.85323713689007 +DTXSID3022908 Css 3compartmentss Human 95% 0.03929 mg/L 0.05067 mg/L 0.77540951253207 +DTXSID3022950 Css 3compartmentss Human 95% 0.9833 mg/L 0.6993 mg/L 1.40612040612041 +DTXSID3022956 Css 3compartmentss Human 95% 7.449 mg/L 2.559 mg/L 2.91090269636577 +DTXSID3022958 Css 3compartmentss Human 95% 2.492 mg/L 1.194 mg/L 2.08710217755444 +DTXSID3023001 Css 3compartmentss Human 95% 4.115 mg/L 4845 mg/L 0.000849329205366357 +DTXSID3023005 Css 3compartmentss Human 95% 0.666 mg/L 27.73 mg/L 0.0240173097728092 +DTXSID3023007 Css 3compartmentss Human 95% 1.729 mg/L 0.3983 mg/L 4.34094903339192 +DTXSID30230090 Css 3compartmentss Human 95% 1.976 mg/L NA NA NA +DTXSID3023051 Css 3compartmentss Human 95% 13.28 mg/L 168.2 mg/L 0.0789536266349584 +DTXSID3023057 Css 3compartmentss Human 95% 3.482 mg/L 5.873 mg/L 0.592882683466712 +DTXSID3023059 Css 3compartmentss Human 95% 4.862 mg/L 5.048 mg/L 0.963153724247227 +DTXSID3023132 Css 3compartmentss Human 95% 7.814 mg/L 3.021 mg/L 2.58656074147633 +DTXSID3023188 Css 3compartmentss Human 95% 1.678 mg/L 1.936 mg/L 0.866735537190083 +DTXSID3023211 Css 3compartmentss Human 95% 1.31 mg/L NA NA NA +DTXSID3023213 Css 3compartmentss Human 95% 0.1522 mg/L NA NA NA +DTXSID3023215 Css 3compartmentss Human 95% 7.263 mg/L NA NA NA +DTXSID3023219 Css 3compartmentss Human 95% 4.593 mg/L 4.156 mg/L 1.10514918190568 +DTXSID3023261 Css 3compartmentss Human 95% 5.305 mg/L 5.848 mg/L 0.907147742818057 +DTXSID3023265 Css 3compartmentss Human 95% 12.87 mg/L 5.316 mg/L 2.42099322799097 +DTXSID3023269 Css 3compartmentss Human 95% 0.6053 mg/L 0.7205 mg/L 0.840111034004164 +DTXSID3023340 Css 3compartmentss Human 95% 1.352 mg/L 5.071 mg/L 0.266614080063104 +DTXSID3023342 Css 3compartmentss Human 95% 3.412 mg/L 1.953 mg/L 1.74705581157194 +DTXSID3023344 Css 3compartmentss Human 95% 3.354 mg/L NA NA NA +DTXSID3023390 Css 3compartmentss Human 95% 2.79 mg/L NA NA NA +DTXSID3023396 Css 3compartmentss Human 95% 7.994 mg/L 7.965 mg/L 1.00364092906466 +DTXSID3023398 Css 3compartmentss Human 95% 1.152 mg/L 1.58 mg/L 0.729113924050633 +DTXSID3023425 Css 3compartmentss Human 95% 13.89 mg/L 0.67 mg/L 20.7313432835821 +DTXSID3023427 Css 3compartmentss Human 95% 7.624 mg/L 2.706 mg/L 2.81744271988174 +DTXSID3023429 Css 3compartmentss Human 95% 0.8664 mg/L NA NA NA +DTXSID3023471 Css 3compartmentss Human 95% 2.214 mg/L 2.423 mg/L 0.913743293437887 +DTXSID3023479 Css 3compartmentss Human 95% 6.394 mg/L 0.9221 mg/L 6.93417199869862 +DTXSID3023502 Css 3compartmentss Human 95% 14.71 mg/L 1.937 mg/L 7.59421786267424 +DTXSID3023550 Css 3compartmentss Human 95% 17.42 mg/L 3.068 mg/L 5.67796610169492 +DTXSID3023552 Css 3compartmentss Human 95% 644.5 mg/L 464.1 mg/L 1.3887093298858 +DTXSID3023554 Css 3compartmentss Human 95% 4.259 mg/L 13.39 mg/L 0.318073188946975 +DTXSID3023556 Css 3compartmentss Human 95% 21.76 mg/L NA NA NA +DTXSID3023631 Css 3compartmentss Human 95% 89.52 mg/L NA NA NA +DTXSID3023639 Css 3compartmentss Human 95% 5.655 mg/L NA NA NA +DTXSID3023681 Css 3compartmentss Human 95% 2.914 mg/L 0.1644 mg/L 17.7250608272506 +DTXSID3023685 Css 3compartmentss Human 95% 10.04 mg/L 11.04 mg/L 0.909420289855073 +DTXSID3023687 Css 3compartmentss Human 95% 0.8295 mg/L 0.1288 mg/L 6.44021739130435 +DTXSID3023712 Css 3compartmentss Human 95% 0.6445 mg/L 0.01326 mg/L 48.604826546003 +DTXSID3023714 Css 3compartmentss Human 95% 4.688 mg/L NA NA NA +DTXSID3023716 Css 3compartmentss Human 95% 2.094 mg/L 31.84 mg/L 0.0657663316582914 +DTXSID3023718 Css 3compartmentss Human 95% 3.23 mg/L 5.438 mg/L 0.593968370724531 +DTXSID30237569 Css 3compartmentss Human 95% 1.041 mg/L NA NA NA +DTXSID3023764 Css 3compartmentss Human 95% 9.497 mg/L 9.318 mg/L 1.01921013092938 +DTXSID3023897 Css 3compartmentss Human 95% 2.073 mg/L 2.563 mg/L 0.80881779165041 +DTXSID30239341 Css 3compartmentss Human 95% 6.7 mg/L NA NA NA +DTXSID3023974 Css 3compartmentss Human 95% 1.929 mg/L 6.417 mg/L 0.300607760635811 +DTXSID3024100 Css 3compartmentss Human 95% 0.7493 mg/L 0.1827 mg/L 4.10125889436234 +DTXSID3024102 Css 3compartmentss Human 95% 2.524 mg/L 2.567 mg/L 0.983248928710557 +DTXSID3024104 Css 3compartmentss Human 95% 20.55 mg/L 21.5 mg/L 0.955813953488372 +DTXSID3024108 Css 3compartmentss Human 95% 3.134 mg/L 244.6 mg/L 0.012812755519215 +DTXSID3024152 Css 3compartmentss Human 95% 6.781 mg/L 6.961 mg/L 0.974141646315185 +DTXSID30241525 Css 3compartmentss Human 95% 90.96 mg/L NA NA NA +DTXSID3024154 Css 3compartmentss Human 95% 20.74 mg/L 4.464 mg/L 4.64605734767025 +DTXSID3024235 Css 3compartmentss Human 95% 21.63 mg/L 24.64 mg/L 0.877840909090909 +DTXSID3024239 Css 3compartmentss Human 95% 2318 mg/L 2713 mg/L 0.854404718024327 +DTXSID3024287 Css 3compartmentss Human 95% 0.9586 mg/L 2.703 mg/L 0.35464298927118 +DTXSID3024289 Css 3compartmentss Human 95% 45.95 mg/L 57.33 mg/L 0.801500087214373 +DTXSID3024316 Css 3compartmentss Human 95% 1.208 mg/L 1.245 mg/L 0.970281124497992 +DTXSID3024318 Css 3compartmentss Human 95% 6.846 mg/L 3.064 mg/L 2.23433420365535 +DTXSID3024364 Css 3compartmentss Human 95% 0.558 mg/L 0.6358 mg/L 0.877634476250393 +DTXSID3024368 Css 3compartmentss Human 95% 5.596 mg/L 5.327 mg/L 1.05049746574057 +DTXSID3024441 Css 3compartmentss Human 95% 0.6121 mg/L 1.865 mg/L 0.328203753351206 +DTXSID3024449 Css 3compartmentss Human 95% 5.867 mg/L 2.385 mg/L 2.45995807127883 +DTXSID3024491 Css 3compartmentss Human 95% 1.305 mg/L 4.095 mg/L 0.318681318681319 +DTXSID3024497 Css 3compartmentss Human 95% 0.324 mg/L 3.337 mg/L 0.097093197482769 +DTXSID3024499 Css 3compartmentss Human 95% 6.127 mg/L 1.181 mg/L 5.18797629127858 +DTXSID3024522 Css 3compartmentss Human 95% 0.3857 mg/L 6.418 mg/L 0.0600966033032097 +DTXSID3024574 Css 3compartmentss Human 95% 0.4006 mg/L 2.11 mg/L 0.189857819905213 +DTXSID3024657 Css 3compartmentss Human 95% 0.2771 mg/L 5.578 mg/L 0.04967730369308 +DTXSID3024736 Css 3compartmentss Human 95% 1.498 mg/L 3.789 mg/L 0.395354974927421 +DTXSID3024738 Css 3compartmentss Human 95% 6.07 mg/L NA NA NA +DTXSID3024786 Css 3compartmentss Human 95% 4.784 mg/L 10.16 mg/L 0.470866141732283 +DTXSID3024815 Css 3compartmentss Human 95% 3.078 mg/L 1.586 mg/L 1.94073139974779 +DTXSID3024869 Css 3compartmentss Human 95% 0.4573 mg/L 11.33 mg/L 0.0403618711385702 +DTXSID3024942 Css 3compartmentss Human 95% 0.3676 mg/L 5.949 mg/L 0.0617918977979492 +DTXSID3024944 Css 3compartmentss Human 95% 0.7478 mg/L 2.22 mg/L 0.336846846846847 +DTXSID3024994 Css 3compartmentss Human 95% 7.617 mg/L 7.836 mg/L 0.972052067381317 +DTXSID3024998 Css 3compartmentss Human 95% 15.64 mg/L 16.01 mg/L 0.976889444097439 +DTXSID3025045 Css 3compartmentss Human 95% 0.35 mg/L 2.151 mg/L 0.162715016271502 +DTXSID3025047 Css 3compartmentss Human 95% 7.659 mg/L 6.944 mg/L 1.10296658986175 +DTXSID3025049 Css 3compartmentss Human 95% 5.454 mg/L 4.976 mg/L 1.09606109324759 +DTXSID3025091 Css 3compartmentss Human 95% 9.275 mg/L 9.434 mg/L 0.98314606741573 +DTXSID3025093 Css 3compartmentss Human 95% 3.515 mg/L 0.3366 mg/L 10.4426619132501 +DTXSID3025122 Css 3compartmentss Human 95% 0.1644 mg/L 0.1655 mg/L 0.993353474320242 +DTXSID3025178 Css 3compartmentss Human 95% 4.757 mg/L 4.218 mg/L 1.12778568041726 +DTXSID3025203 Css 3compartmentss Human 95% 62.51 mg/L 152.3 mg/L 0.410439921208142 +DTXSID3025209 Css 3compartmentss Human 95% 10.98 mg/L 904.6 mg/L 0.012137961529958 +DTXSID3025253 Css 3compartmentss Human 95% 0.6292 mg/L 0.4668 mg/L 1.34790059982862 +DTXSID3025257 Css 3compartmentss Human 95% 7.677 mg/L 16.84 mg/L 0.455878859857482 +DTXSID3025330 Css 3compartmentss Human 95% 1.888 mg/L 1.52 mg/L 1.24210526315789 +DTXSID3025332 Css 3compartmentss Human 95% 8.522 mg/L 5.535 mg/L 1.53965672990063 +DTXSID3025338 Css 3compartmentss Human 95% 0.4017 mg/L 1.538 mg/L 0.261183355006502 +DTXSID3025469 Css 3compartmentss Human 95% 5.258 mg/L 5.849 mg/L 0.898957086681484 +DTXSID3025542 Css 3compartmentss Human 95% 6.674 mg/L 7.817 mg/L 0.853780222591787 +DTXSID3025548 Css 3compartmentss Human 95% 4.314 mg/L 42.09 mg/L 0.102494654312188 +DTXSID3025629 Css 3compartmentss Human 95% 0.5504 mg/L 0.5619 mg/L 0.979533724862075 +DTXSID3025706 Css 3compartmentss Human 95% 8.858 mg/L 23.1 mg/L 0.383463203463203 +DTXSID3025881 Css 3compartmentss Human 95% 7.615 mg/L 0.1977 mg/L 38.5179564997471 +DTXSID3025889 Css 3compartmentss Human 95% 1.035 mg/L 2.2 mg/L 0.470454545454545 +DTXSID3026065 Css 3compartmentss Human 95% 0.766 mg/L 26.74 mg/L 0.0286462228870606 +DTXSID3026067 Css 3compartmentss Human 95% 1.249 mg/L 0.6362 mg/L 1.96321911348633 +DTXSID3026190 Css 3compartmentss Human 95% 3.393 mg/L 10.19 mg/L 0.33297350343474 +DTXSID3026223 Css 3compartmentss Human 95% 0.01366 mg/L 0.0154 mg/L 0.887012987012987 +DTXSID3026279 Css 3compartmentss Human 95% 2.157 mg/L 17.86 mg/L 0.120772676371781 +DTXSID3026304 Css 3compartmentss Human 95% 0.4846 mg/L 1.682 mg/L 0.288109393579073 +DTXSID3026306 Css 3compartmentss Human 95% 0.403 mg/L 1.915 mg/L 0.210443864229765 +DTXSID3026308 Css 3compartmentss Human 95% 0.4117 mg/L 1.983 mg/L 0.207614725163893 +DTXSID3026514 Css 3compartmentss Human 95% 7.829 mg/L 9.237 mg/L 0.847569557215546 +DTXSID3026516 Css 3compartmentss Human 95% 7.095 mg/L 5.511 mg/L 1.2874251497006 +DTXSID3026560 Css 3compartmentss Human 95% 4.069 mg/L 46.9 mg/L 0.0867590618336887 +DTXSID3026562 Css 3compartmentss Human 95% 0.4295 mg/L 1.193 mg/L 0.360016764459346 +DTXSID3026564 Css 3compartmentss Human 95% 10.81 mg/L 12.67 mg/L 0.853196527229676 +DTXSID3026566 Css 3compartmentss Human 95% 0.4465 mg/L 6.958 mg/L 0.0641707387180224 +DTXSID3026641 Css 3compartmentss Human 95% 1.772 mg/L 10.35 mg/L 0.171207729468599 +DTXSID3026647 Css 3compartmentss Human 95% 17.38 mg/L 17.22 mg/L 1.00929152148664 +DTXSID3026697 Css 3compartmentss Human 95% 96.51 mg/L 0.9191 mg/L 105.004896094005 +DTXSID3026724 Css 3compartmentss Human 95% 1.928 mg/L 0.2449 mg/L 7.87260106165782 +DTXSID3026726 Css 3compartmentss Human 95% 4.271 mg/L 5.096 mg/L 0.838108320251177 +DTXSID3026851 Css 3compartmentss Human 95% 0.2984 mg/L 5.165 mg/L 0.0577734753146176 +DTXSID3026984 Css 3compartmentss Human 95% 3.777 mg/L 2.758 mg/L 1.36947063089195 +DTXSID3027037 Css 3compartmentss Human 95% 2.805 mg/L 3.556 mg/L 0.78880764904387 +DTXSID3027039 Css 3compartmentss Human 95% 4.846 mg/L 5.039 mg/L 0.961698749751935 +DTXSID3027085 Css 3compartmentss Human 95% 1.656 mg/L 0.718 mg/L 2.30640668523677 +DTXSID3027247 Css 3compartmentss Human 95% 0.7362 mg/L 9.685 mg/L 0.0760144553433144 +DTXSID3027249 Css 3compartmentss Human 95% 0.8746 mg/L 4.109 mg/L 0.21284984181066 +DTXSID3027297 Css 3compartmentss Human 95% 30.67 mg/L 27.64 mg/L 1.10962373371925 +DTXSID3027320 Css 3compartmentss Human 95% 0.3583 mg/L 0.3627 mg/L 0.98786876206231 +DTXSID3027328 Css 3compartmentss Human 95% 8.069 mg/L 9.153 mg/L 0.881568884518737 +DTXSID3027401 Css 3compartmentss Human 95% 1.716 mg/L 2.011 mg/L 0.853306812531079 +DTXSID3027403 Css 3compartmentss Human 95% 0.4315 mg/L 0.5061 mg/L 0.852598300731081 +DTXSID3027407 Css 3compartmentss Human 95% 6.704 mg/L 7.079 mg/L 0.947026416160475 +DTXSID3027530 Css 3compartmentss Human 95% 9.028 mg/L 103.6 mg/L 0.0871428571428571 +DTXSID3027534 Css 3compartmentss Human 95% 6.677 mg/L 5.091 mg/L 1.3115301512473 +DTXSID3027584 Css 3compartmentss Human 95% 4.224 mg/L 5.512 mg/L 0.766328011611031 +DTXSID3027588 Css 3compartmentss Human 95% 2.604 mg/L 14.68 mg/L 0.177384196185286 +DTXSID3027615 Css 3compartmentss Human 95% 2.38 mg/L 0.826 mg/L 2.88135593220339 +DTXSID3027617 Css 3compartmentss Human 95% 20.12 mg/L 8.228 mg/L 2.44530870199319 +DTXSID3027790 Css 3compartmentss Human 95% 1.558 mg/L 0.4458 mg/L 3.49484073575594 +DTXSID3027792 Css 3compartmentss Human 95% 7.117 mg/L 7.182 mg/L 0.990949596212754 +DTXSID3027798 Css 3compartmentss Human 95% 7.323 mg/L 3.207 mg/L 2.28344246959776 +DTXSID3027823 Css 3compartmentss Human 95% 2.334 mg/L 3.345 mg/L 0.697757847533632 +DTXSID3027829 Css 3compartmentss Human 95% 6.847 mg/L 6.554 mg/L 1.04470552334452 +DTXSID3028001 Css 3compartmentss Human 95% 6.513 mg/L 3.032 mg/L 2.14808707124011 +DTXSID3028005 Css 3compartmentss Human 95% 11.96 mg/L NA NA NA +DTXSID3029150 Css 3compartmentss Human 95% 5.012 mg/L 2.089 mg/L 2.39923408329344 +DTXSID3029152 Css 3compartmentss Human 95% 0.8574 mg/L 0.5607 mg/L 1.52915997859818 +DTXSID3029154 Css 3compartmentss Human 95% 2.792 mg/L 3.176 mg/L 0.879093198992443 +DTXSID3029158 Css 3compartmentss Human 95% 6.008 mg/L 4.327 mg/L 1.3884908712734 +DTXSID3029231 Css 3compartmentss Human 95% 2.514 mg/L 2.939 mg/L 0.855392990813202 +DTXSID3029233 Css 3compartmentss Human 95% 11.44 mg/L 44.43 mg/L 0.257483682196714 +DTXSID3029237 Css 3compartmentss Human 95% 0.5139 mg/L 1.055 mg/L 0.487109004739337 +DTXSID3029283 Css 3compartmentss Human 95% 8.566 mg/L 9.805 mg/L 0.873635900050994 +DTXSID3029287 Css 3compartmentss Human 95% 5.269 mg/L 5.706 mg/L 0.92341395022783 +DTXSID3029289 Css 3compartmentss Human 95% 6.705 mg/L 5.258 mg/L 1.27519969570179 +DTXSID3029312 Css 3compartmentss Human 95% 73.15 mg/L 70.98 mg/L 1.03057199211045 +DTXSID3029362 Css 3compartmentss Human 95% 18.42 mg/L 0.09223 mg/L 199.718096064187 +DTXSID3029364 Css 3compartmentss Human 95% 4.828 mg/L 2.026 mg/L 2.38302073050346 +DTXSID30293827 Css 3compartmentss Human 95% 9.983 mg/L NA NA NA +DTXSID3029572 Css 3compartmentss Human 95% 1.649 mg/L 2.731 mg/L 0.603808128890516 +DTXSID3029607 Css 3compartmentss Human 95% 0.38 mg/L 1.368 mg/L 0.277777777777778 +DTXSID3029651 Css 3compartmentss Human 95% 7.173 mg/L 8.572 mg/L 0.836794213719085 +DTXSID3029655 Css 3compartmentss Human 95% 6.34 mg/L 6.553 mg/L 0.967495803448802 +DTXSID3029869 Css 3compartmentss Human 95% 24.26 mg/L 17.4 mg/L 1.39425287356322 +DTXSID3030056 Css 3compartmentss Human 95% 5806 mg/L NA NA NA +DTXSID3030189 Css 3compartmentss Human 95% 3.166 mg/L 18.43 mg/L 0.171785132935431 +DTXSID3030428 Css 3compartmentss Human 95% 7.287 mg/L 1.011 mg/L 7.20771513353116 +DTXSID3030636 Css 3compartmentss Human 95% 8.814 mg/L 14.38 mg/L 0.612934631432545 +DTXSID3031521 Css 3compartmentss Human 95% 4.074 mg/L 5.609 mg/L 0.726332679622036 +DTXSID3031654 Css 3compartmentss Human 95% 1.202 mg/L NA NA NA +DTXSID3032129 Css 3compartmentss Human 95% 6.338 mg/L NA NA NA +DTXSID3032337 Css 3compartmentss Human 95% 14.74 mg/L 10.27 mg/L 1.43524829600779 +DTXSID3032389 Css 3compartmentss Human 95% 14.02 mg/L 3.134 mg/L 4.47351627313338 +DTXSID3032416 Css 3compartmentss Human 95% 1.953 mg/L 3.137 mg/L 0.622569333758368 +DTXSID3032464 Css 3compartmentss Human 95% 3.028 mg/L 2.493 mg/L 1.21460088247092 +DTXSID3032541 Css 3compartmentss Human 95% 10.77 mg/L 21.6 mg/L 0.498611111111111 +DTXSID3032547 Css 3compartmentss Human 95% 1.733 mg/L 0.7711 mg/L 2.24743872390092 +DTXSID3032549 Css 3compartmentss Human 95% 2.723 mg/L 2.837 mg/L 0.959816707789919 +DTXSID3032591 Css 3compartmentss Human 95% 6.833 mg/L NA NA NA +DTXSID3032620 Css 3compartmentss Human 95% 90.47 mg/L 33.42 mg/L 2.70706163973668 +DTXSID3032622 Css 3compartmentss Human 95% 3.309 mg/L 4.245 mg/L 0.779505300353357 +DTXSID3032626 Css 3compartmentss Human 95% 1.676 mg/L 0.5162 mg/L 3.24680356450988 +DTXSID3032628 Css 3compartmentss Human 95% 6.759 mg/L 6.542 mg/L 1.03317028431672 +DTXSID3032670 Css 3compartmentss Human 95% 5.254 mg/L 46.73 mg/L 0.112433126471218 +DTXSID30326861 Css 3compartmentss Human 95% 1.783 mg/L NA NA NA +DTXSID3032751 Css 3compartmentss Human 95% 0.38 mg/L 2 mg/L 0.19 +DTXSID3032759 Css 3compartmentss Human 95% 0.6435 mg/L 3.939 mg/L 0.163366336633663 +DTXSID3032832 Css 3compartmentss Human 95% 6.437 mg/L 7.324 mg/L 0.878891316220645 +DTXSID30330241 Css 3compartmentss Human 95% 0.5177 mg/L NA NA NA +DTXSID3033276 Css 3compartmentss Human 95% 7.964 mg/L 7.108 mg/L 1.12042768711311 +DTXSID3033519 Css 3compartmentss Human 95% 4.803 mg/L 5.615 mg/L 0.855387355298308 +DTXSID30336723 Css 3compartmentss Human 95% 6.865 mg/L NA NA NA +DTXSID30338242 Css 3compartmentss Human 95% 0.3681 mg/L NA NA NA +DTXSID3033989 Css 3compartmentss Human 95% 4.205 mg/L 330.7 mg/L 0.0127154520713638 +DTXSID3034113 Css 3compartmentss Human 95% 2.051 mg/L 10.45 mg/L 0.196267942583732 +DTXSID3034165 Css 3compartmentss Human 95% 13.95 mg/L 13.6 mg/L 1.02573529411765 +DTXSID3034402 Css 3compartmentss Human 95% 4.092 mg/L 2.833 mg/L 1.44440522414402 +DTXSID3034456 Css 3compartmentss Human 95% 10.81 mg/L 9.886 mg/L 1.09346550677726 +DTXSID3034458 Css 3compartmentss Human 95% 8.588 mg/L 29.41 mg/L 0.292009520571234 +DTXSID3034531 Css 3compartmentss Human 95% 2.034 mg/L 0.4911 mg/L 4.14172266340867 +DTXSID3034583 Css 3compartmentss Human 95% 12.03 mg/L 5.452 mg/L 2.20652971386647 +DTXSID3034612 Css 3compartmentss Human 95% 1.378 mg/L 1.326 mg/L 1.03921568627451 +DTXSID3034614 Css 3compartmentss Human 95% 0.03228 mg/L 19.7 mg/L 0.00163857868020305 +DTXSID3034618 Css 3compartmentss Human 95% 0.08093 mg/L 0.06329 mg/L 1.2787170169063 +DTXSID3034662 Css 3compartmentss Human 95% 1.889 mg/L 7.861 mg/L 0.240300216257474 +DTXSID3034664 Css 3compartmentss Human 95% 4.187 mg/L 7.361 mg/L 0.568808585789974 +DTXSID3034799 Css 3compartmentss Human 95% 0.3939 mg/L NA NA NA +DTXSID30349419 Css 3compartmentss Human 95% 4.783 mg/L NA NA NA +DTXSID3034957 Css 3compartmentss Human 95% 20.46 mg/L 5.491 mg/L 3.72609725004553 +DTXSID3035341 Css 3compartmentss Human 95% 7.483 mg/L NA NA NA +DTXSID3036496 Css 3compartmentss Human 95% 9.632 mg/L 9.807 mg/L 0.982155603140614 +DTXSID3036525 Css 3compartmentss Human 95% 6.238 mg/L 11 mg/L 0.567090909090909 +DTXSID3036654 Css 3compartmentss Human 95% 1.813 mg/L NA NA NA +DTXSID30367996 Css 3compartmentss Human 95% 0.5632 mg/L NA NA NA +DTXSID3036999 Css 3compartmentss Human 95% 4.354 mg/L 8.049 mg/L 0.540936762330724 +DTXSID3037044 Css 3compartmentss Human 95% 0.4503 mg/L 0.61 mg/L 0.738196721311475 +DTXSID3037094 Css 3compartmentss Human 95% 3.071 mg/L 3.584 mg/L 0.856863839285714 +DTXSID3037125 Css 3compartmentss Human 95% 17.08 mg/L NA NA NA +DTXSID3037208 Css 3compartmentss Human 95% 32.28 mg/L 30.97 mg/L 1.04229899903132 +DTXSID3037250 Css 3compartmentss Human 95% 25.51 mg/L 59.33 mg/L 0.429967975728974 +DTXSID3037541 Css 3compartmentss Human 95% 94.65 mg/L 95.94 mg/L 0.986554096310194 +DTXSID3037545 Css 3compartmentss Human 95% 0.6664 mg/L 0.688 mg/L 0.968604651162791 +DTXSID3037626 Css 3compartmentss Human 95% 26.32 mg/L 165.3 mg/L 0.159225650332728 +DTXSID3037672 Css 3compartmentss Human 95% 6.914 mg/L 8.007 mg/L 0.863494442362932 +DTXSID3037703 Css 3compartmentss Human 95% 6.79 mg/L NA NA NA +DTXSID30386304 Css 3compartmentss Human 95% 16.47 mg/L NA NA NA +DTXSID3038694 Css 3compartmentss Human 95% 0.5551 mg/L 2.875 mg/L 0.193078260869565 +DTXSID3038800 Css 3compartmentss Human 95% 0.361 mg/L 0.335 mg/L 1.07761194029851 +DTXSID3038852 Css 3compartmentss Human 95% 4.34 mg/L 50.66 mg/L 0.0856691669956573 +DTXSID30390643 Css 3compartmentss Human 95% 2.495 mg/L NA NA NA +DTXSID3039240 Css 3compartmentss Human 95% 2.848 mg/L 3.278 mg/L 0.86882245271507 +DTXSID3040279 Css 3compartmentss Human 95% 17.99 mg/L 18.89 mg/L 0.952355743779777 +DTXSID3040487 Css 3compartmentss Human 95% 5.031 mg/L NA NA NA +DTXSID3040643 Css 3compartmentss Human 95% 0.7686 mg/L 0.5007 mg/L 1.53505092869982 +DTXSID3040647 Css 3compartmentss Human 95% 4.926 mg/L 0.2552 mg/L 19.3025078369906 +DTXSID3040691 Css 3compartmentss Human 95% 1.833 mg/L 6.557 mg/L 0.279548574043007 +DTXSID3040693 Css 3compartmentss Human 95% 4.506 mg/L NA NA NA +DTXSID3040699 Css 3compartmentss Human 95% 25.87 mg/L 1096 mg/L 0.0236040145985401 +DTXSID3040720 Css 3compartmentss Human 95% 2.502 mg/L 15.59 mg/L 0.16048749198204 +DTXSID3040722 Css 3compartmentss Human 95% 8.457 mg/L 124.3 mg/L 0.0680370072405471 +DTXSID3040724 Css 3compartmentss Human 95% 0.8685 mg/L 0.304 mg/L 2.85690789473684 +DTXSID3040726 Css 3compartmentss Human 95% 0.948 mg/L 0.9342 mg/L 1.01477199743096 +DTXSID3040728 Css 3compartmentss Human 95% 7.807 mg/L 0.5049 mg/L 15.462467815409 +DTXSID3040770 Css 3compartmentss Human 95% 19.02 mg/L 6.778 mg/L 2.8061375036884 +DTXSID3040776 Css 3compartmentss Human 95% 575.8 mg/L 945.8 mg/L 0.608796785789808 +DTXSID3040801 Css 3compartmentss Human 95% 16.15 mg/L 40.27 mg/L 0.401042960019866 +DTXSID3040980 Css 3compartmentss Human 95% 2.083 mg/L 2.292 mg/L 0.908813263525306 +DTXSID3041035 Css 3compartmentss Human 95% 0.4928 mg/L 0.3749 mg/L 1.3144838623633 +DTXSID3041085 Css 3compartmentss Human 95% 4.162 mg/L 0.7228 mg/L 5.75816270060874 +DTXSID3041241 Css 3compartmentss Human 95% 6.46 mg/L NA NA NA +DTXSID3041247 Css 3compartmentss Human 95% 17.79 mg/L 7.307 mg/L 2.43465170384563 +DTXSID3041293 Css 3compartmentss Human 95% 0.3538 mg/L 0.2079 mg/L 1.7017797017797 +DTXSID3041299 Css 3compartmentss Human 95% 1.584 mg/L 51.89 mg/L 0.0305261129312006 +DTXSID3041328 Css 3compartmentss Human 95% 15.27 mg/L 69.36 mg/L 0.220155709342561 +DTXSID3041370 Css 3compartmentss Human 95% 5.435 mg/L 2.896 mg/L 1.87672651933702 +DTXSID3041372 Css 3compartmentss Human 95% 31.48 mg/L 162.2 mg/L 0.194081381011097 +DTXSID3041376 Css 3compartmentss Human 95% 35.72 mg/L 20.3 mg/L 1.75960591133005 +DTXSID3041403 Css 3compartmentss Human 95% 1.324 mg/L 0.05583 mg/L 23.7148486476805 +DTXSID3041405 Css 3compartmentss Human 95% 0.7162 mg/L 8.964 mg/L 0.0798973672467648 +DTXSID3041409 Css 3compartmentss Human 95% 0.1805 mg/L 0.1809 mg/L 0.997788833609729 +DTXSID3041451 Css 3compartmentss Human 95% 1.534 mg/L 6.286 mg/L 0.244034362074451 +DTXSID3041530 Css 3compartmentss Human 95% 1.757 mg/L 9.3 mg/L 0.188924731182796 +DTXSID3041580 Css 3compartmentss Human 95% 6.08 mg/L 5.697 mg/L 1.06722836580656 +DTXSID3041582 Css 3compartmentss Human 95% 20.88 mg/L NA NA NA +DTXSID3041611 Css 3compartmentss Human 95% 15.61 mg/L 291.7 mg/L 0.0535138841275283 +DTXSID3041613 Css 3compartmentss Human 95% 2.479 mg/L 5.369 mg/L 0.461724715962004 +DTXSID3041615 Css 3compartmentss Human 95% 2.611 mg/L 2.251 mg/L 1.15992892047979 +DTXSID3041617 Css 3compartmentss Human 95% 3.095 mg/L 3.554 mg/L 0.870849746764209 +DTXSID3041619 Css 3compartmentss Human 95% 5.389 mg/L 15.64 mg/L 0.344565217391304 +DTXSID3041661 Css 3compartmentss Human 95% 0.475 mg/L 8.369 mg/L 0.0567570796988888 +DTXSID3041663 Css 3compartmentss Human 95% 19.72 mg/L 12.73 mg/L 1.5490966221524 +DTXSID3041744 Css 3compartmentss Human 95% 11.9 mg/L 29.75 mg/L 0.4 +DTXSID3041794 Css 3compartmentss Human 95% 30.37 mg/L 29.49 mg/L 1.02984062394032 +DTXSID3041827 Css 3compartmentss Human 95% 5.285 mg/L 32.17 mg/L 0.164283493938452 +DTXSID3041873 Css 3compartmentss Human 95% 8.02 mg/L 4.124 mg/L 1.9447138700291 +DTXSID3042051 Css 3compartmentss Human 95% 0.9885 mg/L 0.8246 mg/L 1.19876303662382 +DTXSID3042053 Css 3compartmentss Human 95% 0.6235 mg/L 29.63 mg/L 0.0210428619642254 +DTXSID3042180 Css 3compartmentss Human 95% 2.947 mg/L 1.774 mg/L 1.66121758737317 +DTXSID3042188 Css 3compartmentss Human 95% 0.3804 mg/L 0.3909 mg/L 0.973138910207214 +DTXSID3042261 Css 3compartmentss Human 95% 17.37 mg/L 21.84 mg/L 0.79532967032967 +DTXSID3042269 Css 3compartmentss Human 95% 21.56 mg/L 5.941 mg/L 3.62901868372328 +DTXSID3042344 Css 3compartmentss Human 95% 0.2403 mg/L NA NA NA +DTXSID3042390 Css 3compartmentss Human 95% 6.791 mg/L 8.108 mg/L 0.83756783423779 +DTXSID3042394 Css 3compartmentss Human 95% 8.443 mg/L 23.46 mg/L 0.359889173060529 +DTXSID3042423 Css 3compartmentss Human 95% 0.03433 mg/L 0.04293 mg/L 0.799673887724202 +DTXSID3042477 Css 3compartmentss Human 95% 7.085 mg/L 2.766 mg/L 2.56146059291396 +DTXSID3042508 Css 3compartmentss Human 95% 4.681 mg/L 7.718 mg/L 0.606504275719098 +DTXSID3042631 Css 3compartmentss Human 95% 3.276 mg/L NA NA NA +DTXSID3042633 Css 3compartmentss Human 95% 92.61 mg/L 1177 mg/L 0.0786830926083262 +DTXSID3042681 Css 3compartmentss Human 95% 11.62 mg/L 1.411 mg/L 8.23529411764706 +DTXSID3042685 Css 3compartmentss Human 95% 0.8816 mg/L NA NA NA +DTXSID30431303 Css 3compartmentss Human 95% 0.3245 mg/L NA NA NA +DTXSID3043734 Css 3compartmentss Human 95% 3.146 mg/L 5.729 mg/L 0.549135974864723 +DTXSID3043782 Css 3compartmentss Human 95% 10.99 mg/L 40.46 mg/L 0.271626297577855 +DTXSID3043861 Css 3compartmentss Human 95% 0.2498 mg/L NA NA NA +DTXSID3044122 Css 3compartmentss Human 95% 20.19 mg/L NA NA NA +DTXSID3044124 Css 3compartmentss Human 95% 5.192 mg/L 0.8651 mg/L 6.00161831002196 +DTXSID3044201 Css 3compartmentss Human 95% 0.6309 mg/L 0.7799 mg/L 0.808949865367355 +DTXSID3044203 Css 3compartmentss Human 95% 24.51 mg/L 27.79 mg/L 0.881971932349766 +DTXSID3044205 Css 3compartmentss Human 95% 5.3 mg/L 1.059 mg/L 5.00472143531634 +DTXSID3044209 Css 3compartmentss Human 95% 15.4 mg/L NA NA NA +DTXSID3044251 Css 3compartmentss Human 95% 0.4781 mg/L 0.3692 mg/L 1.29496208017335 +DTXSID3044259 Css 3compartmentss Human 95% 5.615 mg/L NA NA NA +DTXSID3044338 Css 3compartmentss Human 95% 2.611 mg/L 2.868 mg/L 0.910390516039052 +DTXSID3044380 Css 3compartmentss Human 95% 10.11 mg/L 8.334 mg/L 1.21310295176386 +DTXSID3044382 Css 3compartmentss Human 95% 0.396 mg/L 0.9929 mg/L 0.398831705106254 +DTXSID3044388 Css 3compartmentss Human 95% 5.766 mg/L 6.912 mg/L 0.834201388888889 +DTXSID3044411 Css 3compartmentss Human 95% 6.461 mg/L 0.4458 mg/L 14.4930462090624 +DTXSID3044413 Css 3compartmentss Human 95% 5.355 mg/L 5.388 mg/L 0.993875278396437 +DTXSID3044415 Css 3compartmentss Human 95% 4.049 mg/L 0.6299 mg/L 6.42800444515002 +DTXSID3044461 Css 3compartmentss Human 95% 0.6891 mg/L 6.671 mg/L 0.103297856393344 +DTXSID3044465 Css 3compartmentss Human 95% 0.2483 mg/L 0.2973 mg/L 0.835183316515304 +DTXSID3044469 Css 3compartmentss Human 95% 5.411 mg/L 5.512 mg/L 0.981676342525399 +DTXSID3044542 Css 3compartmentss Human 95% 1.188 mg/L 0.414 mg/L 2.8695652173913 +DTXSID3044544 Css 3compartmentss Human 95% 14.06 mg/L 19.47 mg/L 0.722136620441705 +DTXSID3044590 Css 3compartmentss Human 95% 1130 mg/L 1147 mg/L 0.985178727114211 +DTXSID3044598 Css 3compartmentss Human 95% 4.494 mg/L 5.267 mg/L 0.85323713689007 +DTXSID3044621 Css 3compartmentss Human 95% 0.0009473 mg/L 0.002769 mg/L 0.342109064644276 +DTXSID3044623 Css 3compartmentss Human 95% 0.2927 mg/L 5.852 mg/L 0.0500170881749829 +DTXSID3044625 Css 3compartmentss Human 95% 4.893 mg/L 5.544 mg/L 0.882575757575758 +DTXSID3044627 Css 3compartmentss Human 95% 7.173 mg/L 14.73 mg/L 0.486965376782077 +DTXSID3044629 Css 3compartmentss Human 95% 4.56 mg/L 8.169 mg/L 0.558207858979067 +DTXSID3044679 Css 3compartmentss Human 95% 7.389 mg/L 3.289 mg/L 2.24657950744907 +DTXSID3044702 Css 3compartmentss Human 95% 1.934 mg/L 4.065 mg/L 0.475768757687577 +DTXSID3044704 Css 3compartmentss Human 95% 1073 mg/L 1212 mg/L 0.885313531353135 +DTXSID3044706 Css 3compartmentss Human 95% 5.828 mg/L 3.643 mg/L 1.5997804007686 +DTXSID3044750 Css 3compartmentss Human 95% 1.756 mg/L 0.5633 mg/L 3.11734422155157 +DTXSID3044752 Css 3compartmentss Human 95% 7.768 mg/L 3.602 mg/L 2.15657967795669 +DTXSID3044758 Css 3compartmentss Human 95% 14.34 mg/L 237.3 mg/L 0.0604298356510746 +DTXSID3044831 Css 3compartmentss Human 95% 0.9212 mg/L 0.1765 mg/L 5.21926345609065 +DTXSID3044833 Css 3compartmentss Human 95% 11.9 mg/L NA NA NA +DTXSID3044835 Css 3compartmentss Human 95% 15.89 mg/L 32.45 mg/L 0.489676425269646 +DTXSID3044837 Css 3compartmentss Human 95% 6.403 mg/L 0.8589 mg/L 7.45488415415066 +DTXSID3044881 Css 3compartmentss Human 95% 6.935 mg/L 0.01487 mg/L 466.375252185609 +DTXSID3044883 Css 3compartmentss Human 95% 8.106 mg/L 6.753 mg/L 1.20035539760107 +DTXSID3044887 Css 3compartmentss Human 95% 6.255 mg/L 43.96 mg/L 0.142288444040036 +DTXSID3044889 Css 3compartmentss Human 95% 12.84 mg/L NA NA NA +DTXSID3044910 Css 3compartmentss Human 95% 5.45 mg/L 4.889 mg/L 1.11474739210472 +DTXSID3044914 Css 3compartmentss Human 95% 57.49 mg/L 67.82 mg/L 0.847685048658213 +DTXSID3044916 Css 3compartmentss Human 95% 8.361 mg/L 7.125 mg/L 1.17347368421053 +DTXSID3044960 Css 3compartmentss Human 95% 2.849 mg/L 5.225 mg/L 0.545263157894737 +DTXSID3044962 Css 3compartmentss Human 95% 2.358 mg/L 11.21 mg/L 0.210347903657449 +DTXSID3044966 Css 3compartmentss Human 95% 10.09 mg/L 20.66 mg/L 0.48838334946757 +DTXSID3045140 Css 3compartmentss Human 95% 3.769 mg/L 100.1 mg/L 0.0376523476523477 +DTXSID3045144 Css 3compartmentss Human 95% 13.44 mg/L 33.69 mg/L 0.39893143365984 +DTXSID3045190 Css 3compartmentss Human 95% 0.9155 mg/L 0.624 mg/L 1.46714743589744 +DTXSID3045192 Css 3compartmentss Human 95% 4.833 mg/L 11.78 mg/L 0.410271646859083 +DTXSID3045194 Css 3compartmentss Human 95% 2.965 mg/L 0.0548 mg/L 54.1058394160584 +DTXSID3045196 Css 3compartmentss Human 95% 3.206 mg/L 0.5804 mg/L 5.52377670572019 +DTXSID3045198 Css 3compartmentss Human 95% 8.15 mg/L 1.225 mg/L 6.6530612244898 +DTXSID3045221 Css 3compartmentss Human 95% 1.425 mg/L 0.4849 mg/L 2.93875025778511 +DTXSID3045223 Css 3compartmentss Human 95% 0.3303 mg/L 0.6392 mg/L 0.516739674593242 +DTXSID3045225 Css 3compartmentss Human 95% 7.645 mg/L 8.802 mg/L 0.868552601681436 +DTXSID3045227 Css 3compartmentss Human 95% 1.398 mg/L 5.86 mg/L 0.238566552901024 +DTXSID3045271 Css 3compartmentss Human 95% 1.32 mg/L 0.2239 mg/L 5.89548905761501 +DTXSID3045300 Css 3compartmentss Human 95% 1.038 mg/L 0.5176 mg/L 2.00540958268934 +DTXSID3045304 Css 3compartmentss Human 95% 1.481 mg/L 1.495 mg/L 0.990635451505017 +DTXSID3045306 Css 3compartmentss Human 95% 11.27 mg/L 3.191 mg/L 3.53180821059229 +DTXSID3045350 Css 3compartmentss Human 95% 4.704 mg/L 5.135 mg/L 0.916066212268744 +DTXSID3045356 Css 3compartmentss Human 95% 4.423 mg/L 2.638 mg/L 1.67664897649735 +DTXSID3045433 Css 3compartmentss Human 95% 9.547 mg/L 3.46 mg/L 2.75924855491329 +DTXSID3045435 Css 3compartmentss Human 95% 12.68 mg/L 6.195 mg/L 2.04681194511703 +DTXSID3045437 Css 3compartmentss Human 95% 5.353 mg/L 4.29 mg/L 1.24778554778555 +DTXSID3045439 Css 3compartmentss Human 95% 2.346 mg/L 1.044 mg/L 2.24712643678161 +DTXSID3045485 Css 3compartmentss Human 95% 0.3194 mg/L 0.5468 mg/L 0.584125822970007 +DTXSID3045514 Css 3compartmentss Human 95% 1.61 mg/L 0.4585 mg/L 3.51145038167939 +DTXSID3045560 Css 3compartmentss Human 95% 0.5208 mg/L 28.81 mg/L 0.0180770565775772 +DTXSID3045562 Css 3compartmentss Human 95% 1.811 mg/L 0.4452 mg/L 4.06783468104223 +DTXSID3045566 Css 3compartmentss Human 95% 1.037 mg/L 9.974 mg/L 0.103970322839382 +DTXSID3045568 Css 3compartmentss Human 95% 6.059 mg/L 26.45 mg/L 0.229073724007561 +DTXSID3045645 Css 3compartmentss Human 95% 1.381 mg/L 5.869 mg/L 0.235304140398705 +DTXSID3045647 Css 3compartmentss Human 95% 1.158 mg/L 4.482 mg/L 0.258366800535475 +DTXSID3045649 Css 3compartmentss Human 95% 4.374 mg/L 5.253 mg/L 0.832667047401485 +DTXSID3045691 Css 3compartmentss Human 95% 0.7201 mg/L 10.75 mg/L 0.0669860465116279 +DTXSID3045693 Css 3compartmentss Human 95% 5.011 mg/L 560.6 mg/L 0.00893863717445594 +DTXSID3045695 Css 3compartmentss Human 95% 1.144 mg/L 2.702 mg/L 0.423390081421169 +DTXSID3045697 Css 3compartmentss Human 95% 1.072 mg/L 4.175 mg/L 0.256766467065868 +DTXSID3045699 Css 3compartmentss Human 95% 1.981 mg/L 5.727 mg/L 0.345905360572726 +DTXSID3045770 Css 3compartmentss Human 95% 0.9336 mg/L 0.9227 mg/L 1.01181315703912 +DTXSID3045772 Css 3compartmentss Human 95% 0.6264 mg/L 0.09676 mg/L 6.47374948325754 +DTXSID3045774 Css 3compartmentss Human 95% 0.4365 mg/L 1.233 mg/L 0.354014598540146 +DTXSID3045776 Css 3compartmentss Human 95% 1.364 mg/L 1.654 mg/L 0.824667472793229 +DTXSID3045778 Css 3compartmentss Human 95% 0.7257 mg/L NA NA NA +DTXSID3045803 Css 3compartmentss Human 95% 0.5575 mg/L 0.7509 mg/L 0.742442402450393 +DTXSID3045805 Css 3compartmentss Human 95% 0.9226 mg/L 0.1434 mg/L 6.43375174337517 +DTXSID3045807 Css 3compartmentss Human 95% 1.285 mg/L 0.3521 mg/L 3.64953138312979 +DTXSID3045809 Css 3compartmentss Human 95% 1.57 mg/L 3.998 mg/L 0.392696348174087 +DTXSID3045851 Css 3compartmentss Human 95% 8.537 mg/L 4.863 mg/L 1.75550071972034 +DTXSID3045855 Css 3compartmentss Human 95% 5.097 mg/L 5.625 mg/L 0.906133333333333 +DTXSID3045857 Css 3compartmentss Human 95% 1.157 mg/L 1.776 mg/L 0.651463963963964 +DTXSID3045859 Css 3compartmentss Human 95% 1.847 mg/L 1.685 mg/L 1.09614243323442 +DTXSID3045930 Css 3compartmentss Human 95% 11.84 mg/L 6.5 mg/L 1.82153846153846 +DTXSID3045934 Css 3compartmentss Human 95% 6.667 mg/L 1.272 mg/L 5.24135220125786 +DTXSID3045938 Css 3compartmentss Human 95% 5.769 mg/L 0.03187 mg/L 181.016630059617 +DTXSID3045980 Css 3compartmentss Human 95% 9.915 mg/L 0.6692 mg/L 14.8161984459056 +DTXSID3045988 Css 3compartmentss Human 95% 0.7182 mg/L 17.87 mg/L 0.0401902630106323 +DTXSID3046083 Css 3compartmentss Human 95% 21.11 mg/L 16.62 mg/L 1.27015643802647 +DTXSID3046085 Css 3compartmentss Human 95% 4.993 mg/L 7.638 mg/L 0.653705158418434 +DTXSID3046110 Css 3compartmentss Human 95% 1.668 mg/L 0.3737 mg/L 4.46347337436446 +DTXSID3046112 Css 3compartmentss Human 95% 4.448 mg/L 2.41 mg/L 1.84564315352697 +DTXSID3046114 Css 3compartmentss Human 95% 2.304 mg/L 2.862 mg/L 0.80503144654088 +DTXSID3046116 Css 3compartmentss Human 95% 20.31 mg/L 9.614 mg/L 2.11254420636572 +DTXSID3046118 Css 3compartmentss Human 95% 2.905 mg/L 24.85 mg/L 0.116901408450704 +DTXSID3046160 Css 3compartmentss Human 95% 16.98 mg/L 8.917 mg/L 1.90422787933161 +DTXSID3046162 Css 3compartmentss Human 95% 6.79 mg/L 1.276 mg/L 5.32131661442006 +DTXSID3046164 Css 3compartmentss Human 95% 0.5543 mg/L 4.182 mg/L 0.132544237207078 +DTXSID3046166 Css 3compartmentss Human 95% 8.193 mg/L 0.08147 mg/L 100.564625015343 +DTXSID3046245 Css 3compartmentss Human 95% 2.895 mg/L 3.108 mg/L 0.931467181467181 +DTXSID3046247 Css 3compartmentss Human 95% 6.899 mg/L 2.373 mg/L 2.90729034976823 +DTXSID3046291 Css 3compartmentss Human 95% 1.638 mg/L 17.75 mg/L 0.0922816901408451 +DTXSID3046295 Css 3compartmentss Human 95% 0.5291 mg/L 1.239 mg/L 0.427037933817595 +DTXSID3046297 Css 3compartmentss Human 95% 7.109 mg/L 13.85 mg/L 0.513285198555957 +DTXSID3046299 Css 3compartmentss Human 95% 0.9375 mg/L 0.2988 mg/L 3.13755020080321 +DTXSID3046320 Css 3compartmentss Human 95% 0.9732 mg/L 6.083 mg/L 0.159986848594444 +DTXSID3046322 Css 3compartmentss Human 95% 2.665 mg/L 1.286 mg/L 2.07231726283048 +DTXSID3046324 Css 3compartmentss Human 95% 1.224 mg/L 9.52 mg/L 0.128571428571429 +DTXSID3046326 Css 3compartmentss Human 95% 5.585 mg/L 1.642 mg/L 3.40133982947625 +DTXSID3046401 Css 3compartmentss Human 95% 0.8864 mg/L 2.827 mg/L 0.313547930668553 +DTXSID3046403 Css 3compartmentss Human 95% 4.389 mg/L 5.45 mg/L 0.805321100917431 +DTXSID3046405 Css 3compartmentss Human 95% 5.021 mg/L 0.02507 mg/L 200.279218189071 +DTXSID3046407 Css 3compartmentss Human 95% 6.95 mg/L 0.5776 mg/L 12.0325484764543 +DTXSID3046409 Css 3compartmentss Human 95% 0.9362 mg/L 0.6994 mg/L 1.33857592221904 +DTXSID3046451 Css 3compartmentss Human 95% 4.324 mg/L 0.282 mg/L 15.3333333333333 +DTXSID3046453 Css 3compartmentss Human 95% 18.72 mg/L 22.27 mg/L 0.840592725639874 +DTXSID3046457 Css 3compartmentss Human 95% 2.864 mg/L 6.224 mg/L 0.460154241645244 +DTXSID3046459 Css 3compartmentss Human 95% 1.411 mg/L 13.24 mg/L 0.106570996978852 +DTXSID3046530 Css 3compartmentss Human 95% 4.968 mg/L 5.532 mg/L 0.898047722342733 +DTXSID3046532 Css 3compartmentss Human 95% 3.816 mg/L 17.36 mg/L 0.219815668202765 +DTXSID3046534 Css 3compartmentss Human 95% 4.291 mg/L 4.202 mg/L 1.02118039029034 +DTXSID3046536 Css 3compartmentss Human 95% 7.163 mg/L 5.81 mg/L 1.2328743545611 +DTXSID3046580 Css 3compartmentss Human 95% 3.572 mg/L 1.787 mg/L 1.99888080581981 +DTXSID3046584 Css 3compartmentss Human 95% 0.5396 mg/L 5.303 mg/L 0.101753724306996 +DTXSID3046586 Css 3compartmentss Human 95% 2.068 mg/L 2.421 mg/L 0.854192482445271 +DTXSID3046615 Css 3compartmentss Human 95% 1.302 mg/L 2.425 mg/L 0.536907216494845 +DTXSID3046617 Css 3compartmentss Human 95% 2.244 mg/L 62.77 mg/L 0.0357495618926239 +DTXSID3046619 Css 3compartmentss Human 95% 16.18 mg/L 19.11 mg/L 0.846677132391418 +DTXSID3046663 Css 3compartmentss Human 95% 0.1519 mg/L 0.28 mg/L 0.5425 +DTXSID3046665 Css 3compartmentss Human 95% 14.42 mg/L 2.703 mg/L 5.33481317055124 +DTXSID3046740 Css 3compartmentss Human 95% 15.04 mg/L 22.13 mg/L 0.679620424762766 +DTXSID3046744 Css 3compartmentss Human 95% 1.43 mg/L 8.312 mg/L 0.172040423484119 +DTXSID3046748 Css 3compartmentss Human 95% 4.227 mg/L 6.403 mg/L 0.660159300327971 +DTXSID3046790 Css 3compartmentss Human 95% 4.602 mg/L 1.076 mg/L 4.27695167286245 +DTXSID3046792 Css 3compartmentss Human 95% 19.3 mg/L 2.376 mg/L 8.12289562289562 +DTXSID3046796 Css 3compartmentss Human 95% 3.121 mg/L 12.54 mg/L 0.248883572567783 +DTXSID3046798 Css 3compartmentss Human 95% 1.326 mg/L 11.68 mg/L 0.113527397260274 +DTXSID3046821 Css 3compartmentss Human 95% 0.3049 mg/L 0.9931 mg/L 0.307018427147316 +DTXSID3046823 Css 3compartmentss Human 95% 4.916 mg/L 8.813 mg/L 0.557812322705095 +DTXSID3046825 Css 3compartmentss Human 95% 3.401 mg/L 7.299 mg/L 0.465954240306891 +DTXSID3046827 Css 3compartmentss Human 95% 1.009 mg/L 1.77 mg/L 0.570056497175141 +DTXSID30468614 Css 3compartmentss Human 95% 11.61 mg/L NA NA NA +DTXSID3046871 Css 3compartmentss Human 95% 7.481 mg/L 5.939 mg/L 1.25963966997811 +DTXSID3046875 Css 3compartmentss Human 95% 0.3623 mg/L 0.6228 mg/L 0.581727681438664 +DTXSID3046879 Css 3compartmentss Human 95% 15.84 mg/L 215.6 mg/L 0.073469387755102 +DTXSID3046902 Css 3compartmentss Human 95% 0.8601 mg/L 0.8638 mg/L 0.995716601065061 +DTXSID3046904 Css 3compartmentss Human 95% 0.617 mg/L 0.1537 mg/L 4.01431359791802 +DTXSID3046906 Css 3compartmentss Human 95% 1.878 mg/L 150.7 mg/L 0.0124618447246184 +DTXSID3046908 Css 3compartmentss Human 95% 183.7 mg/L 372.2 mg/L 0.49355185384202 +DTXSID3047001 Css 3compartmentss Human 95% 0.5199 mg/L NA NA NA +DTXSID3047059 Css 3compartmentss Human 95% 1.599 mg/L NA NA NA +DTXSID3047130 Css 3compartmentss Human 95% 3.417 mg/L NA NA NA +DTXSID3047132 Css 3compartmentss Human 95% 0.659 mg/L 0.977 mg/L 0.674513817809621 +DTXSID3047182 Css 3compartmentss Human 95% 1.339 mg/L 3.695 mg/L 0.362381596752368 +DTXSID3047184 Css 3compartmentss Human 95% 2.137 mg/L 2.548 mg/L 0.838697017268446 +DTXSID3047186 Css 3compartmentss Human 95% 5.458 mg/L 0.4911 mg/L 11.113826104663 +DTXSID3047217 Css 3compartmentss Human 95% 0.3001 mg/L NA NA NA +DTXSID3047261 Css 3compartmentss Human 95% 2.461 mg/L 133.7 mg/L 0.0184068810770381 +DTXSID3047263 Css 3compartmentss Human 95% 1.488 mg/L 15.83 mg/L 0.0939987365761213 +DTXSID3047265 Css 3compartmentss Human 95% 5.963 mg/L 47.02 mg/L 0.126818375159507 +DTXSID3047267 Css 3compartmentss Human 95% 1.557 mg/L 0.9797 mg/L 1.5892620189854 +DTXSID3047342 Css 3compartmentss Human 95% 1.257 mg/L 0.2415 mg/L 5.20496894409938 +DTXSID3047344 Css 3compartmentss Human 95% 4.698 mg/L 4.526 mg/L 1.03800265134777 +DTXSID3047346 Css 3compartmentss Human 95% 0.4333 mg/L 0.08259 mg/L 5.2463978689914 +DTXSID3047348 Css 3compartmentss Human 95% 3.335 mg/L 1.432 mg/L 2.32891061452514 +DTXSID3047423 Css 3compartmentss Human 95% 0.752 mg/L 2.96 mg/L 0.254054054054054 +DTXSID3047425 Css 3compartmentss Human 95% 0.9833 mg/L 0.9838 mg/L 0.999491766619231 +DTXSID3047429 Css 3compartmentss Human 95% 1.834 mg/L 3.037 mg/L 0.603885413236747 +DTXSID3047471 Css 3compartmentss Human 95% 4.37 mg/L 5.124 mg/L 0.852849336455894 +DTXSID3047477 Css 3compartmentss Human 95% 6.77 mg/L 6.642 mg/L 1.01927130382415 +DTXSID3047504 Css 3compartmentss Human 95% 0.8531 mg/L 0.05456 mg/L 15.6359970674487 +DTXSID3047508 Css 3compartmentss Human 95% 20.04 mg/L 7.507 mg/L 2.66950845877181 +DTXSID3047554 Css 3compartmentss Human 95% 10.32 mg/L 6.278 mg/L 1.64383561643836 +DTXSID3047631 Css 3compartmentss Human 95% 0.3285 mg/L 5.266 mg/L 0.0623813140903912 +DTXSID3047681 Css 3compartmentss Human 95% 0.2915 mg/L 4.764 mg/L 0.0611880772460117 +DTXSID3047683 Css 3compartmentss Human 95% 7.145 mg/L 2.267 mg/L 3.15174239082488 +DTXSID3047687 Css 3compartmentss Human 95% 5.214 mg/L 6.477 mg/L 0.805002315886985 +DTXSID3047716 Css 3compartmentss Human 95% 8.405 mg/L 5.437 mg/L 1.54588927717491 +DTXSID3047843 Css 3compartmentss Human 95% 14.61 mg/L 23.11 mg/L 0.632193855473821 +DTXSID3047845 Css 3compartmentss Human 95% 0.3349 mg/L 0.762 mg/L 0.439501312335958 +DTXSID3047847 Css 3compartmentss Human 95% 0.8698 mg/L 0.556 mg/L 1.56438848920863 +DTXSID3047849 Css 3compartmentss Human 95% 5.147 mg/L 1.06 mg/L 4.85566037735849 +DTXSID3047891 Css 3compartmentss Human 95% 0.9448 mg/L 0.8273 mg/L 1.14202828478182 +DTXSID3047893 Css 3compartmentss Human 95% 22.95 mg/L 33.11 mg/L 0.693144065237088 +DTXSID3047895 Css 3compartmentss Human 95% 4.045 mg/L 8.196 mg/L 0.493533430941923 +DTXSID3047897 Css 3compartmentss Human 95% 5.24 mg/L 5.769 mg/L 0.908302998786618 +DTXSID3047922 Css 3compartmentss Human 95% 37.28 mg/L NA NA NA +DTXSID3047924 Css 3compartmentss Human 95% 8.017 mg/L 9.973 mg/L 0.803870450215582 +DTXSID3047972 Css 3compartmentss Human 95% 4.599 mg/L 5.398 mg/L 0.851982215635421 +DTXSID3047974 Css 3compartmentss Human 95% 7.263 mg/L 88.42 mg/L 0.0821420493101108 +DTXSID3048287 Css 3compartmentss Human 95% 0.1881 mg/L NA NA NA +DTXSID3048289 Css 3compartmentss Human 95% 51.65 mg/L NA NA NA +DTXSID3048310 Css 3compartmentss Human 95% 6.157 mg/L 6.063 mg/L 1.01550387596899 +DTXSID3048312 Css 3compartmentss Human 95% 4.125 mg/L NA NA NA +DTXSID3048318 Css 3compartmentss Human 95% 13.94 mg/L NA NA NA +DTXSID3048449 Css 3compartmentss Human 95% 5.521 mg/L 0.3297 mg/L 16.7455262359721 +DTXSID3048491 Css 3compartmentss Human 95% 1.438 mg/L NA NA NA +DTXSID3048493 Css 3compartmentss Human 95% 0.8403 mg/L NA NA NA +DTXSID3048495 Css 3compartmentss Human 95% 1.179 mg/L NA NA NA +DTXSID3048520 Css 3compartmentss Human 95% 0.6339 mg/L 0.739 mg/L 0.857780784844384 +DTXSID3048522 Css 3compartmentss Human 95% 2.869 mg/L 1.164 mg/L 2.46477663230241 +DTXSID3048574 Css 3compartmentss Human 95% 0.7035 mg/L 7.49 mg/L 0.0939252336448598 +DTXSID3048576 Css 3compartmentss Human 95% 0.4105 mg/L 10.76 mg/L 0.0381505576208178 +DTXSID3048578 Css 3compartmentss Human 95% 9.652 mg/L 4.548 mg/L 2.12225153913808 +DTXSID3048601 Css 3compartmentss Human 95% 106.4 mg/L 5.968 mg/L 17.828418230563 +DTXSID3048603 Css 3compartmentss Human 95% 3.149 mg/L 1.47 mg/L 2.1421768707483 +DTXSID3048605 Css 3compartmentss Human 95% 7.177 mg/L 0.0655 mg/L 109.572519083969 +DTXSID3048607 Css 3compartmentss Human 95% 11.99 mg/L 10.07 mg/L 1.19066534260179 +DTXSID3048609 Css 3compartmentss Human 95% 6.638 mg/L 0.3947 mg/L 16.8178363313909 +DTXSID3048653 Css 3compartmentss Human 95% 14.07 mg/L 2.593 mg/L 5.4261473197069 +DTXSID3048655 Css 3compartmentss Human 95% 1.887 mg/L 0.7527 mg/L 2.50697489039458 +DTXSID3048657 Css 3compartmentss Human 95% 2.184 mg/L 22.53 mg/L 0.0969374167776298 +DTXSID3048659 Css 3compartmentss Human 95% 0.76 mg/L 0.9804 mg/L 0.775193798449612 +DTXSID3048730 Css 3compartmentss Human 95% 1.711 mg/L 15.18 mg/L 0.112714097496706 +DTXSID3048732 Css 3compartmentss Human 95% 5.468 mg/L 12.65 mg/L 0.432252964426877 +DTXSID3048734 Css 3compartmentss Human 95% 19.49 mg/L 1.112 mg/L 17.5269784172662 +DTXSID3048736 Css 3compartmentss Human 95% 8.691 mg/L 4.227 mg/L 2.05606813342796 +DTXSID3048780 Css 3compartmentss Human 95% 18.71 mg/L 8.264 mg/L 2.26403678606002 +DTXSID3048782 Css 3compartmentss Human 95% 279.1 mg/L 310.9 mg/L 0.897716307494371 +DTXSID3048786 Css 3compartmentss Human 95% 11.58 mg/L NA NA NA +DTXSID3048788 Css 3compartmentss Human 95% 4.619 mg/L 1.11 mg/L 4.16126126126126 +DTXSID3048811 Css 3compartmentss Human 95% 19.15 mg/L 4.694 mg/L 4.07967618236046 +DTXSID3048813 Css 3compartmentss Human 95% 1.788 mg/L 0.06917 mg/L 25.8493566575105 +DTXSID3048815 Css 3compartmentss Human 95% 2.411 mg/L 2.822 mg/L 0.854358610914245 +DTXSID3048817 Css 3compartmentss Human 95% 6.006 mg/L 6.026 mg/L 0.996681048788583 +DTXSID3048819 Css 3compartmentss Human 95% 13.8 mg/L 9.626 mg/L 1.43361728651569 +DTXSID3048861 Css 3compartmentss Human 95% 7.599 mg/L 9.105 mg/L 0.834596375617792 +DTXSID3048863 Css 3compartmentss Human 95% 3.015 mg/L 5.918 mg/L 0.509462656302805 +DTXSID3048865 Css 3compartmentss Human 95% 0.243 mg/L 0.372 mg/L 0.653225806451613 +DTXSID3048867 Css 3compartmentss Human 95% 0.5217 mg/L 1.519 mg/L 0.343449637919684 +DTXSID3048869 Css 3compartmentss Human 95% 0.6162 mg/L 0.3026 mg/L 2.03635161929941 +DTXSID3048940 Css 3compartmentss Human 95% 5.446 mg/L 8.696 mg/L 0.626264949402024 +DTXSID3048942 Css 3compartmentss Human 95% 13.71 mg/L 1.714 mg/L 7.99883313885648 +DTXSID3048944 Css 3compartmentss Human 95% 1.497 mg/L 37.61 mg/L 0.0398032438181335 +DTXSID3048948 Css 3compartmentss Human 95% 4.332 mg/L 10.94 mg/L 0.395978062157221 +DTXSID3048992 Css 3compartmentss Human 95% 1.356 mg/L 2.054 mg/L 0.660175267770205 +DTXSID3048996 Css 3compartmentss Human 95% 20.64 mg/L 2.587 mg/L 7.97835330498647 +DTXSID3048998 Css 3compartmentss Human 95% 9.893 mg/L 21.48 mg/L 0.460567970204842 +DTXSID3049041 Css 3compartmentss Human 95% 0.9417 mg/L 0.2532 mg/L 3.71919431279621 +DTXSID3049043 Css 3compartmentss Human 95% 18.03 mg/L 4.968 mg/L 3.6292270531401 +DTXSID3049045 Css 3compartmentss Human 95% 2.26 mg/L 0.1877 mg/L 12.0404901438466 +DTXSID3049047 Css 3compartmentss Human 95% 5.881 mg/L 1.095 mg/L 5.37077625570776 +DTXSID3049049 Css 3compartmentss Human 95% 91.58 mg/L 17.76 mg/L 5.15653153153153 +DTXSID30491982 Css 3compartmentss Human 95% 18.68 mg/L NA NA NA +DTXSID3049330 Css 3compartmentss Human 95% 0.3254 mg/L 6.877 mg/L 0.0473171441035335 +DTXSID3049332 Css 3compartmentss Human 95% 10.03 mg/L NA NA NA +DTXSID3049334 Css 3compartmentss Human 95% 0.2403 mg/L 5.866 mg/L 0.0409648823729969 +DTXSID3049336 Css 3compartmentss Human 95% 4.916 mg/L 5.035 mg/L 0.976365441906653 +DTXSID3049413 Css 3compartmentss Human 95% 2.342 mg/L 1.772 mg/L 1.32167042889391 +DTXSID3049415 Css 3compartmentss Human 95% 5.347 mg/L 1.236 mg/L 4.32605177993528 +DTXSID3049417 Css 3compartmentss Human 95% 5.601 mg/L 6.459 mg/L 0.867162099396191 +DTXSID3049419 Css 3compartmentss Human 95% 0.9218 mg/L 0.304 mg/L 3.03223684210526 +DTXSID3051381 Css 3compartmentss Human 95% 2.542 mg/L NA NA NA +DTXSID3051707 Css 3compartmentss Human 95% 0.1581 mg/L 0.1829 mg/L 0.864406779661017 +DTXSID3051834 Css 3compartmentss Human 95% 19.91 mg/L 3.386 mg/L 5.88009450679268 +DTXSID3051836 Css 3compartmentss Human 95% 6.541 mg/L 6.022 mg/L 1.08618399202923 +DTXSID3051888 Css 3compartmentss Human 95% 6.297 mg/L NA NA NA +DTXSID3052060 Css 3compartmentss Human 95% 0.2252 mg/L NA NA NA +DTXSID3052143 Css 3compartmentss Human 95% 1.333 mg/L NA NA NA +DTXSID3052278 Css 3compartmentss Human 95% 1.204 mg/L 2.712 mg/L 0.443952802359882 +DTXSID3052301 Css 3compartmentss Human 95% 0.3119 mg/L 0.5014 mg/L 0.622058236936578 +DTXSID3052309 Css 3compartmentss Human 95% 0.9044 mg/L NA NA NA +DTXSID3052511 Css 3compartmentss Human 95% 23.46 mg/L 55.46 mg/L 0.423007573025604 +DTXSID3052567 Css 3compartmentss Human 95% 8.109 mg/L 7.726 mg/L 1.04957287082578 +DTXSID3052696 Css 3compartmentss Human 95% 0.5363 mg/L NA NA NA +DTXSID3057640 Css 3compartmentss Human 95% 1.363 mg/L 0.2048 mg/L 6.6552734375 +DTXSID3057642 Css 3compartmentss Human 95% 2.576 mg/L 1.038 mg/L 2.48169556840077 +DTXSID3057644 Css 3compartmentss Human 95% 6.854 mg/L 11.73 mg/L 0.584313725490196 +DTXSID3057646 Css 3compartmentss Human 95% 1.347 mg/L 4.609 mg/L 0.292254285094381 +DTXSID3057648 Css 3compartmentss Human 95% 6.45 mg/L 2.411 mg/L 2.67523849025301 +DTXSID3057690 Css 3compartmentss Human 95% 5.078 mg/L 6.202 mg/L 0.8187681393099 +DTXSID3057692 Css 3compartmentss Human 95% 3.35 mg/L 1.476 mg/L 2.26964769647696 +DTXSID3057694 Css 3compartmentss Human 95% 1.413 mg/L 0.3303 mg/L 4.27792915531335 +DTXSID3057696 Css 3compartmentss Human 95% 0.4638 mg/L 1.14 mg/L 0.406842105263158 +DTXSID3057698 Css 3compartmentss Human 95% 6.557 mg/L 5.399 mg/L 1.21448416373402 +DTXSID3057721 Css 3compartmentss Human 95% 2.492 mg/L NA NA NA +DTXSID3057723 Css 3compartmentss Human 95% 3.904 mg/L 4.022 mg/L 0.970661362506216 +DTXSID3057725 Css 3compartmentss Human 95% 6.214 mg/L 7.722 mg/L 0.804713804713805 +DTXSID3057729 Css 3compartmentss Human 95% 2.849 mg/L 2.912 mg/L 0.978365384615385 +DTXSID3057771 Css 3compartmentss Human 95% 6.245 mg/L 47.01 mg/L 0.132844075728568 +DTXSID3057773 Css 3compartmentss Human 95% 5.78 mg/L 5.572 mg/L 1.03732950466619 +DTXSID3057775 Css 3compartmentss Human 95% 1.161 mg/L 0.0375 mg/L 30.96 +DTXSID3057777 Css 3compartmentss Human 95% 2.568 mg/L 5.928 mg/L 0.433198380566802 +DTXSID3057779 Css 3compartmentss Human 95% 0.5966 mg/L 0.07369 mg/L 8.09607816528701 +DTXSID3057800 Css 3compartmentss Human 95% 1.021 mg/L 1.268 mg/L 0.805205047318612 +DTXSID3057802 Css 3compartmentss Human 95% 1.729 mg/L 1.565 mg/L 1.10479233226837 +DTXSID3057804 Css 3compartmentss Human 95% 0.9611 mg/L 5.14 mg/L 0.186984435797665 +DTXSID3057806 Css 3compartmentss Human 95% 2.541 mg/L 1.884 mg/L 1.34872611464968 +DTXSID3057808 Css 3compartmentss Human 95% 6.434 mg/L 5.46 mg/L 1.17838827838828 +DTXSID3057850 Css 3compartmentss Human 95% 0.5695 mg/L 7.476 mg/L 0.0761771000535045 +DTXSID3057852 Css 3compartmentss Human 95% 11.59 mg/L 0.2364 mg/L 49.0270727580372 +DTXSID3057854 Css 3compartmentss Human 95% 20.28 mg/L 24.11 mg/L 0.841144753214434 +DTXSID3057856 Css 3compartmentss Human 95% 7.318 mg/L 0.002001 mg/L 3657.17141429285 +DTXSID3057858 Css 3compartmentss Human 95% 0.7374 mg/L 1.148 mg/L 0.642334494773519 +DTXSID3058749 Css 3compartmentss Human 95% 24.1 mg/L NA NA NA +DTXSID3059189 Css 3compartmentss Human 95% 7.052 mg/L NA NA NA +DTXSID3061635 Css 3compartmentss Human 95% 11.72 mg/L NA NA NA +DTXSID3063469 Css 3compartmentss Human 95% 5.997 mg/L NA NA NA +DTXSID3065089 Css 3compartmentss Human 95% 0.6668 mg/L NA NA NA +DTXSID30669861 Css 3compartmentss Human 95% 8.8 mg/L NA NA NA +DTXSID30720926 Css 3compartmentss Human 95% 7.617 mg/L NA NA NA +DTXSID3075044 Css 3compartmentss Human 95% 14.34 mg/L NA NA NA +DTXSID3075204 Css 3compartmentss Human 95% 17.86 mg/L NA NA NA +DTXSID30861722 Css 3compartmentss Human 95% 5.326 mg/L NA NA NA +DTXSID30865361 Css 3compartmentss Human 95% 5.853 mg/L NA NA NA +DTXSID30865801 Css 3compartmentss Human 95% 0.4839 mg/L 0.5026 mg/L 0.962793473935535 +DTXSID30866414 Css 3compartmentss Human 95% 1.349 mg/L 0.7308 mg/L 1.84592227695676 +DTXSID30866550 Css 3compartmentss Human 95% 1.15 mg/L NA NA NA +DTXSID30868236 Css 3compartmentss Human 95% 0.7149 mg/L NA NA NA +DTXSID30869521 Css 3compartmentss Human 95% 20.13 mg/L NA NA NA +DTXSID30870132 Css 3compartmentss Human 95% 0.9873 mg/L NA NA NA +DTXSID30871200 Css 3compartmentss Human 95% 14.81 mg/L NA NA NA +DTXSID30873365 Css 3compartmentss Human 95% 2.036 mg/L NA NA NA +DTXSID30873385 Css 3compartmentss Human 95% 30.72 mg/L NA NA NA +DTXSID30880630 Css 3compartmentss Human 95% 0.3446 mg/L NA NA NA +DTXSID30880635 Css 3compartmentss Human 95% 0.1738 mg/L NA NA NA +DTXSID30880690 Css 3compartmentss Human 95% 11.48 mg/L NA NA NA +DTXSID30880711 Css 3compartmentss Human 95% 13.41 mg/L NA NA NA +DTXSID30880812 Css 3compartmentss Human 95% 8.94 mg/L NA NA NA +DTXSID30880892 Css 3compartmentss Human 95% 0.652 mg/L NA NA NA +DTXSID30880918 Css 3compartmentss Human 95% 1.799 mg/L NA NA NA +DTXSID30881203 Css 3compartmentss Human 95% 1.062 mg/L NA NA NA +DTXSID30881243 Css 3compartmentss Human 95% 6.765 mg/L NA NA NA +DTXSID30892970 Css 3compartmentss Human 95% 1.309 mg/L NA NA NA +DTXSID30893700 Css 3compartmentss Human 95% 2.441 mg/L NA NA NA +DTXSID30895042 Css 3compartmentss Human 95% 2.408 mg/L NA NA NA +DTXSID30960103 Css 3compartmentss Human 95% 6.02 mg/L NA NA NA +DTXSID30974109 Css 3compartmentss Human 95% 20.5 mg/L NA NA NA +DTXSID30976289 Css 3compartmentss Human 95% 1.202 mg/L NA NA NA +DTXSID401017163 Css 3compartmentss Human 95% 12.71 mg/L 2.402 mg/L 5.29142381348876 +DTXSID401100653 Css 3compartmentss Human 95% 7.856 mg/L NA NA NA +DTXSID40110071 Css 3compartmentss Human 95% 1.401 mg/L NA NA NA +DTXSID401105722 Css 3compartmentss Human 95% 1.226 mg/L NA NA NA +DTXSID401108938 Css 3compartmentss Human 95% 2.241 mg/L NA NA NA +DTXSID401313244 Css 3compartmentss Human 95% 5.093 mg/L NA NA NA +DTXSID40143768 Css 3compartmentss Human 95% 304.8 mg/L 359 mg/L 0.849025069637883 +DTXSID40146032 Css 3compartmentss Human 95% 6.79 mg/L NA NA NA +DTXSID40151606 Css 3compartmentss Human 95% 18.8 mg/L NA NA NA +DTXSID40153120 Css 3compartmentss Human 95% 3.832 mg/L NA NA NA +DTXSID40153741 Css 3compartmentss Human 95% 1.176 mg/L NA NA NA +DTXSID40158594 Css 3compartmentss Human 95% 11.75 mg/L NA NA NA +DTXSID40164418 Css 3compartmentss Human 95% 0.3815 mg/L NA NA NA +DTXSID40164615 Css 3compartmentss Human 95% 2.485 mg/L NA NA NA +DTXSID40165748 Css 3compartmentss Human 95% 14.62 mg/L NA NA NA +DTXSID40167045 Css 3compartmentss Human 95% 5.358 mg/L NA NA NA +DTXSID40167161 Css 3compartmentss Human 95% 6.849 mg/L NA NA NA +DTXSID40167363 Css 3compartmentss Human 95% 130.8 mg/L NA NA NA +DTXSID40170938 Css 3compartmentss Human 95% 10.29 mg/L NA NA NA +DTXSID40171081 Css 3compartmentss Human 95% 1.017 mg/L NA NA NA +DTXSID40171389 Css 3compartmentss Human 95% 0.7925 mg/L NA NA NA +DTXSID40172316 Css 3compartmentss Human 95% 17.22 mg/L NA NA NA +DTXSID40172331 Css 3compartmentss Human 95% 2.997 mg/L NA NA NA +DTXSID40174158 Css 3compartmentss Human 95% 4.098 mg/L NA NA NA +DTXSID40177109 Css 3compartmentss Human 95% 17.1 mg/L NA NA NA +DTXSID40178252 Css 3compartmentss Human 95% 0.4819 mg/L NA NA NA +DTXSID40182293 Css 3compartmentss Human 95% 23.48 mg/L NA NA NA +DTXSID40190611 Css 3compartmentss Human 95% 10.04 mg/L NA NA NA +DTXSID40192791 Css 3compartmentss Human 95% 1.124 mg/L NA NA NA +DTXSID40193304 Css 3compartmentss Human 95% 1.434 mg/L NA NA NA +DTXSID40193506 Css 3compartmentss Human 95% 7.526 mg/L NA NA NA +DTXSID40195580 Css 3compartmentss Human 95% 8.527 mg/L NA NA NA +DTXSID40195984 Css 3compartmentss Human 95% 3.244 mg/L NA NA NA +DTXSID40196133 Css 3compartmentss Human 95% 13.35 mg/L NA NA NA +DTXSID40196931 Css 3compartmentss Human 95% 7.895 mg/L NA NA NA +DTXSID4020032 Css 3compartmentss Human 95% 5.609 mg/L 5.538 mg/L 1.01282051282051 +DTXSID4020038 Css 3compartmentss Human 95% 2.909 mg/L 35.23 mg/L 0.0825716718705649 +DTXSID4020088 Css 3compartmentss Human 95% 7.537 mg/L 8.982 mg/L 0.839122689824093 +DTXSID4020113 Css 3compartmentss Human 95% 3.55 mg/L 3.625 mg/L 0.979310344827586 +DTXSID4020117 Css 3compartmentss Human 95% 0.1384 mg/L 5.533 mg/L 0.0250135550334357 +DTXSID4020119 Css 3compartmentss Human 95% 3.949 mg/L 6.467 mg/L 0.610638626874903 +DTXSID4020240 Css 3compartmentss Human 95% 2.91 mg/L 3.028 mg/L 0.961030383091149 +DTXSID4020242 Css 3compartmentss Human 95% 174.2 mg/L 127.5 mg/L 1.36627450980392 +DTXSID4020244 Css 3compartmentss Human 95% 5.073 mg/L 5.531 mg/L 0.917193997468812 +DTXSID4020248 Css 3compartmentss Human 95% 15.58 mg/L 24.25 mg/L 0.642474226804124 +DTXSID4020290 Css 3compartmentss Human 95% 137.9 mg/L 145.8 mg/L 0.945816186556927 +DTXSID4020292 Css 3compartmentss Human 95% 4.716 mg/L NA NA NA +DTXSID4020294 Css 3compartmentss Human 95% 0.6607 mg/L 1.838 mg/L 0.359466811751904 +DTXSID4020296 Css 3compartmentss Human 95% 0.7404 mg/L 0.7639 mg/L 0.969236811100929 +DTXSID4020321 Css 3compartmentss Human 95% 0.377 mg/L 1.307 mg/L 0.288446824789594 +DTXSID4020327 Css 3compartmentss Human 95% 8.591 mg/L 9.805 mg/L 0.876185619581846 +DTXSID40203270 Css 3compartmentss Human 95% 1.65 mg/L NA NA NA +DTXSID4020329 Css 3compartmentss Human 95% 0.5918 mg/L 0.6153 mg/L 0.961807248496668 +DTXSID40203619 Css 3compartmentss Human 95% 9.098 mg/L NA NA NA +DTXSID4020371 Css 3compartmentss Human 95% 4.974 mg/L 5.805 mg/L 0.856847545219638 +DTXSID4020373 Css 3compartmentss Human 95% 10790 mg/L 11190 mg/L 0.964253798033959 +DTXSID4020375 Css 3compartmentss Human 95% 22.22 mg/L 21.4 mg/L 1.03831775700935 +DTXSID4020379 Css 3compartmentss Human 95% 2.12 mg/L 6.25 mg/L 0.3392 +DTXSID4020400 Css 3compartmentss Human 95% 2.255 mg/L 2.354 mg/L 0.957943925233645 +DTXSID4020402 Css 3compartmentss Human 95% 7.349 mg/L 5.408 mg/L 1.35891272189349 +DTXSID4020406 Css 3compartmentss Human 95% 90.72 mg/L 114.7 mg/L 0.790932868352223 +DTXSID4020450 Css 3compartmentss Human 95% 113.9 mg/L 112 mg/L 1.01696428571429 +DTXSID4020452 Css 3compartmentss Human 95% 8.577 mg/L NA NA NA +DTXSID4020458 Css 3compartmentss Human 95% 135.2 mg/L 160.7 mg/L 0.841319228375856 +DTXSID4020533 Css 3compartmentss Human 95% 0.852 mg/L 0.9715 mg/L 0.87699433865157 +DTXSID4020535 Css 3compartmentss Human 95% 3.207 mg/L 3.266 mg/L 0.981935088793631 +DTXSID4020537 Css 3compartmentss Human 95% 6.516 mg/L 6.011 mg/L 1.08401264348694 +DTXSID4020581 Css 3compartmentss Human 95% 2.682 mg/L 2.829 mg/L 0.948038176033934 +DTXSID4020589 Css 3compartmentss Human 95% 21.34 mg/L 34.99 mg/L 0.609888539582738 +DTXSID4020612 Css 3compartmentss Human 95% 0.4231 mg/L 1.895 mg/L 0.223271767810026 +DTXSID4020614 Css 3compartmentss Human 95% 17.94 mg/L 1.361 mg/L 13.1814842027921 +DTXSID4020618 Css 3compartmentss Human 95% 2.901 mg/L 17 mg/L 0.170647058823529 +DTXSID4020664 Css 3compartmentss Human 95% 4.859 mg/L 5.427 mg/L 0.895338124193846 +DTXSID4020666 Css 3compartmentss Human 95% 5.577 mg/L 6.501 mg/L 0.857868020304568 +DTXSID4020668 Css 3compartmentss Human 95% 2.724 mg/L 3.132 mg/L 0.869731800766284 +DTXSID4020745 Css 3compartmentss Human 95% 0.3782 mg/L 2.013 mg/L 0.187878787878788 +DTXSID4020749 Css 3compartmentss Human 95% 2.94 mg/L 0.2886 mg/L 10.1871101871102 +DTXSID4020791 Css 3compartmentss Human 95% 0.0365 mg/L 0.07897 mg/L 0.462200835760415 +DTXSID4020820 Css 3compartmentss Human 95% 7.687 mg/L 5.403 mg/L 1.42272811401073 +DTXSID4020822 Css 3compartmentss Human 95% 3.294 mg/L 3.504 mg/L 0.940068493150685 +DTXSID4020826 Css 3compartmentss Human 95% 0.3549 mg/L 0.9936 mg/L 0.357185990338164 +DTXSID4020828 Css 3compartmentss Human 95% 0.2759 mg/L 0.2686 mg/L 1.02717795979151 +DTXSID4020870 Css 3compartmentss Human 95% 23.05 mg/L 22.28 mg/L 1.03456014362657 +DTXSID4020876 Css 3compartmentss Human 95% 0.3481 mg/L 1.423 mg/L 0.244624033731553 +DTXSID4020901 Css 3compartmentss Human 95% 6.518 mg/L 7.256 mg/L 0.898291069459757 +DTXSID4020957 Css 3compartmentss Human 95% 0.3959 mg/L 0.1354 mg/L 2.92392909896603 +DTXSID4020959 Css 3compartmentss Human 95% 0.6666 mg/L 0.3799 mg/L 1.75467228217952 +DTXSID4021002 Css 3compartmentss Human 95% 1.261 mg/L 0.06465 mg/L 19.5050270688322 +DTXSID4021006 Css 3compartmentss Human 95% 4.192 mg/L 4.876 mg/L 0.859721082854799 +DTXSID4021056 Css 3compartmentss Human 95% 5.286 mg/L 4.513 mg/L 1.1712829603368 +DTXSID4021131 Css 3compartmentss Human 95% 15.76 mg/L 6.304 mg/L 2.5 +DTXSID4021133 Css 3compartmentss Human 95% 14.87 mg/L 101.2 mg/L 0.146936758893281 +DTXSID4021135 Css 3compartmentss Human 95% 2172 mg/L 1623 mg/L 1.33826247689464 +DTXSID4021137 Css 3compartmentss Human 95% 6.546 mg/L 5.471 mg/L 1.19649058673003 +DTXSID4021139 Css 3compartmentss Human 95% 0.3194 mg/L 2.35 mg/L 0.135914893617021 +DTXSID4021181 Css 3compartmentss Human 95% 14.95 mg/L 10.76 mg/L 1.38940520446097 +DTXSID4021185 Css 3compartmentss Human 95% 5.668 mg/L 7.274 mg/L 0.779213637613418 +DTXSID4021189 Css 3compartmentss Human 95% 0.8615 mg/L 0.1674 mg/L 5.14635603345281 +DTXSID4021210 Css 3compartmentss Human 95% 13.03 mg/L NA NA NA +DTXSID4021212 Css 3compartmentss Human 95% 4.507 mg/L 9.562 mg/L 0.471344906923238 +DTXSID4021214 Css 3compartmentss Human 95% 6.838 mg/L 91.89 mg/L 0.07441506148656 +DTXSID4021216 Css 3compartmentss Human 95% 0.9567 mg/L 0.7764 mg/L 1.2322256568779 +DTXSID4021218 Css 3compartmentss Human 95% 5.39 mg/L 5.445 mg/L 0.98989898989899 +DTXSID4021260 Css 3compartmentss Human 95% 10.88 mg/L 2.359 mg/L 4.61212378126325 +DTXSID4021268 Css 3compartmentss Human 95% 1.231 mg/L 1.533 mg/L 0.803000652315721 +DTXSID4021341 Css 3compartmentss Human 95% 21.48 mg/L 0.8198 mg/L 26.20151256404 +DTXSID4021347 Css 3compartmentss Human 95% 6.462 mg/L 5.245 mg/L 1.23203050524309 +DTXSID4021393 Css 3compartmentss Human 95% 6.328 mg/L 5.515 mg/L 1.14741613780598 +DTXSID4021397 Css 3compartmentss Human 95% 18.41 mg/L 100 mg/L 0.1841 +DTXSID4021424 Css 3compartmentss Human 95% 4.444 mg/L 5.473 mg/L 0.811986113648821 +DTXSID4021426 Css 3compartmentss Human 95% 5.514 mg/L 5.652 mg/L 0.975583864118896 +DTXSID40214326 Css 3compartmentss Human 95% 325.5 mg/L 385.6 mg/L 0.844139004149378 +DTXSID4021472 Css 3compartmentss Human 95% 5.619 mg/L NA NA NA +DTXSID4021478 Css 3compartmentss Human 95% 13.41 mg/L 15.9 mg/L 0.843396226415094 +DTXSID4021559 Css 3compartmentss Human 95% 20.27 mg/L 37.21 mg/L 0.544746036011825 +DTXSID4021632 Css 3compartmentss Human 95% 5.474 mg/L 6.279 mg/L 0.871794871794872 +DTXSID4021636 Css 3compartmentss Human 95% 6.555 mg/L 7.911 mg/L 0.828593098217672 +DTXSID4021680 Css 3compartmentss Human 95% 7.673 mg/L 7.617 mg/L 1.00735197584351 +DTXSID4021684 Css 3compartmentss Human 95% 8.035 mg/L 53.74 mg/L 0.149516189058429 +DTXSID4021715 Css 3compartmentss Human 95% 2.052 mg/L NA NA NA +DTXSID4021717 Css 3compartmentss Human 95% 56.2 mg/L 57.76 mg/L 0.972991689750693 +DTXSID4021761 Css 3compartmentss Human 95% 5.062 mg/L 5.511 mg/L 0.918526583197242 +DTXSID4021769 Css 3compartmentss Human 95% 8.45 mg/L NA NA NA +DTXSID4021842 Css 3compartmentss Human 95% 7.637 mg/L 5.855 mg/L 1.30435525192143 +DTXSID40218445 Css 3compartmentss Human 95% 6.126 mg/L NA NA NA +DTXSID4021848 Css 3compartmentss Human 95% 2.383 mg/L 2.413 mg/L 0.98756734355574 +DTXSID40218506 Css 3compartmentss Human 95% 5.119 mg/L NA NA NA +DTXSID4021892 Css 3compartmentss Human 95% 0.3186 mg/L 1.174 mg/L 0.271379897785349 +DTXSID4021894 Css 3compartmentss Human 95% 0.2964 mg/L 6.081 mg/L 0.048741983226443 +DTXSID4021921 Css 3compartmentss Human 95% 5.596 mg/L 5.068 mg/L 1.10418310970797 +DTXSID4021925 Css 3compartmentss Human 95% 5.44 mg/L NA NA NA +DTXSID4021971 Css 3compartmentss Human 95% 2.069 mg/L 1.861 mg/L 1.11176786673831 +DTXSID4021973 Css 3compartmentss Human 95% 2.512 mg/L 0.4622 mg/L 5.43487667676331 +DTXSID4021975 Css 3compartmentss Human 95% 16.2 mg/L 16.86 mg/L 0.96085409252669 +DTXSID4021977 Css 3compartmentss Human 95% 0.8584 mg/L 1.582 mg/L 0.542604298356511 +DTXSID4021979 Css 3compartmentss Human 95% 5.017 mg/L 5.326 mg/L 0.941982726248592 +DTXSID4022020 Css 3compartmentss Human 95% 54.18 mg/L 56.21 mg/L 0.963885429638854 +DTXSID4022107 Css 3compartmentss Human 95% 6.79 mg/L 2.112 mg/L 3.21496212121212 +DTXSID4022109 Css 3compartmentss Human 95% 0.9196 mg/L 16.54 mg/L 0.0555985489721886 +DTXSID4022151 Css 3compartmentss Human 95% 16.37 mg/L NA NA NA +DTXSID4022284 Css 3compartmentss Human 95% 4.476 mg/L 5.13 mg/L 0.872514619883041 +DTXSID4022288 Css 3compartmentss Human 95% 2.313 mg/L 2.268 mg/L 1.01984126984127 +DTXSID4022311 Css 3compartmentss Human 95% 6.867 mg/L 4.003 mg/L 1.71546340244816 +DTXSID4022313 Css 3compartmentss Human 95% 19.7 mg/L NA NA NA +DTXSID4022315 Css 3compartmentss Human 95% 3.04 mg/L 8.724 mg/L 0.348464007336084 +DTXSID4022319 Css 3compartmentss Human 95% 8.005 mg/L NA NA NA +DTXSID4022361 Css 3compartmentss Human 95% 1.321 mg/L 1.296 mg/L 1.01929012345679 +DTXSID4022367 Css 3compartmentss Human 95% 74.29 mg/L 79.33 mg/L 0.936467918820119 +DTXSID4022442 Css 3compartmentss Human 95% 9.087 mg/L 8.785 mg/L 1.03437677859989 +DTXSID4022446 Css 3compartmentss Human 95% 1.223 mg/L 1.279 mg/L 0.956215793588741 +DTXSID4022448 Css 3compartmentss Human 95% 0.9503 mg/L 1.006 mg/L 0.944632206759443 +DTXSID4022523 Css 3compartmentss Human 95% 12.75 mg/L 3.474 mg/L 3.67012089810017 +DTXSID4022525 Css 3compartmentss Human 95% 1.419 mg/L 7.639 mg/L 0.185757298075664 +DTXSID4022527 Css 3compartmentss Human 95% 1.809 mg/L 1.936 mg/L 0.934400826446281 +DTXSID4022529 Css 3compartmentss Human 95% 0.6548 mg/L 0.677 mg/L 0.967208271787297 +DTXSID4022571 Css 3compartmentss Human 95% 0.412 mg/L 1.435 mg/L 0.287108013937282 +DTXSID4022573 Css 3compartmentss Human 95% 2.882 mg/L 0.8761 mg/L 3.28957881520374 +DTXSID4022577 Css 3compartmentss Human 95% 4.594 mg/L 5.046 mg/L 0.91042409829568 +DTXSID4022579 Css 3compartmentss Human 95% 16.48 mg/L 0.9461 mg/L 17.4188774970933 +DTXSID4022600 Css 3compartmentss Human 95% 4.39 mg/L 4.485 mg/L 0.978818283166109 +DTXSID4022602 Css 3compartmentss Human 95% 2.313 mg/L 1.463 mg/L 1.580997949419 +DTXSID4022604 Css 3compartmentss Human 95% 6.603 mg/L NA NA NA +DTXSID4022652 Css 3compartmentss Human 95% 21.22 mg/L 612.4 mg/L 0.0346505551926845 +DTXSID4022658 Css 3compartmentss Human 95% 0.9279 mg/L 10.75 mg/L 0.0863162790697674 +DTXSID40227299 Css 3compartmentss Human 95% 2.227 mg/L 2.02 mg/L 1.10247524752475 +DTXSID4022731 Css 3compartmentss Human 95% 1.5 mg/L 1.244 mg/L 1.20578778135048 +DTXSID4022735 Css 3compartmentss Human 95% 4.126 mg/L 8.136 mg/L 0.507128810226155 +DTXSID40227810 Css 3compartmentss Human 95% 7.694 mg/L NA NA NA +DTXSID4022783 Css 3compartmentss Human 95% 7.853 mg/L 7.226 mg/L 1.08676999723222 +DTXSID4022785 Css 3compartmentss Human 95% 2.874 mg/L 1.501 mg/L 1.9147235176549 +DTXSID4022787 Css 3compartmentss Human 95% 397.8 mg/L 515.9 mg/L 0.771079666602055 +DTXSID4022789 Css 3compartmentss Human 95% 0.6075 mg/L 4.562 mg/L 0.133165278386673 +DTXSID4022810 Css 3compartmentss Human 95% 23.09 mg/L 5.206 mg/L 4.43526699961583 +DTXSID4022812 Css 3compartmentss Human 95% 1.513 mg/L 0.3729 mg/L 4.05738803968892 +DTXSID4022814 Css 3compartmentss Human 95% 2377 mg/L 2774 mg/L 0.856885364095169 +DTXSID4022816 Css 3compartmentss Human 95% 48.91 mg/L 124.2 mg/L 0.393800322061192 +DTXSID4022862 Css 3compartmentss Human 95% 12.33 mg/L 24.31 mg/L 0.507198683669272 +DTXSID4022864 Css 3compartmentss Human 95% 11.34 mg/L NA NA NA +DTXSID4022866 Css 3compartmentss Human 95% 21.89 mg/L 6.19 mg/L 3.53634894991922 +DTXSID4022868 Css 3compartmentss Human 95% 1.078 mg/L 10.09 mg/L 0.106838453914767 +DTXSID4022941 Css 3compartmentss Human 95% 2.385 mg/L 27.43 mg/L 0.0869485964272694 +DTXSID4022947 Css 3compartmentss Human 95% 24.78 mg/L 51.85 mg/L 0.477917068466731 +DTXSID4022949 Css 3compartmentss Human 95% 1.72 mg/L 1.77 mg/L 0.971751412429378 +DTXSID4022991 Css 3compartmentss Human 95% 20.62 mg/L 22.32 mg/L 0.923835125448029 +DTXSID4022993 Css 3compartmentss Human 95% 10.85 mg/L 0.0356 mg/L 304.775280898876 +DTXSID4022995 Css 3compartmentss Human 95% 0.8376 mg/L NA NA NA +DTXSID4022999 Css 3compartmentss Human 95% 5.256 mg/L 3.674 mg/L 1.43059335873707 +DTXSID4023042 Css 3compartmentss Human 95% 163.4 mg/L 169.4 mg/L 0.964580873671783 +DTXSID4023044 Css 3compartmentss Human 95% 0.761 mg/L 0.6371 mg/L 1.19447496468372 +DTXSID4023046 Css 3compartmentss Human 95% 0.6111 mg/L NA NA NA +DTXSID4023048 Css 3compartmentss Human 95% 0.8299 mg/L NA NA NA +DTXSID4023094 Css 3compartmentss Human 95% 2.132 mg/L 4.008 mg/L 0.531936127744511 +DTXSID4023096 Css 3compartmentss Human 95% 8.212 mg/L 6.528 mg/L 1.25796568627451 +DTXSID4023123 Css 3compartmentss Human 95% 1.183 mg/L 0.3484 mg/L 3.3955223880597 +DTXSID4023125 Css 3compartmentss Human 95% 5.723 mg/L 1.403 mg/L 4.07911617961511 +DTXSID4023129 Css 3compartmentss Human 95% 5.042 mg/L NA NA NA +DTXSID4023171 Css 3compartmentss Human 95% 1.445 mg/L 5.688 mg/L 0.254043600562588 +DTXSID4023175 Css 3compartmentss Human 95% 5.354 mg/L 4.09 mg/L 1.30904645476773 +DTXSID4023177 Css 3compartmentss Human 95% 18.52 mg/L NA NA NA +DTXSID4023179 Css 3compartmentss Human 95% 13.94 mg/L 11.55 mg/L 1.20692640692641 +DTXSID4023200 Css 3compartmentss Human 95% 39.48 mg/L 2.008 mg/L 19.6613545816733 +DTXSID4023202 Css 3compartmentss Human 95% 8.273 mg/L 3.519 mg/L 2.3509519749929 +DTXSID4023252 Css 3compartmentss Human 95% 0.7743 mg/L 4.326 mg/L 0.178987517337032 +DTXSID4023254 Css 3compartmentss Human 95% 0.3643 mg/L 0.1638 mg/L 2.22405372405372 +DTXSID4023258 Css 3compartmentss Human 95% 0.5691 mg/L 5.055 mg/L 0.112581602373887 +DTXSID4023333 Css 3compartmentss Human 95% 21.48 mg/L 31.4 mg/L 0.684076433121019 +DTXSID4023381 Css 3compartmentss Human 95% 10.61 mg/L 2.078 mg/L 5.10587102983638 +DTXSID4023385 Css 3compartmentss Human 95% 2.485 mg/L 4.633 mg/L 0.536369522987265 +DTXSID4023387 Css 3compartmentss Human 95% 4.503 mg/L 1.053 mg/L 4.27635327635328 +DTXSID4023389 Css 3compartmentss Human 95% 7.209 mg/L NA NA NA +DTXSID4023412 Css 3compartmentss Human 95% 6.637 mg/L 8.253 mg/L 0.804192414879438 +DTXSID4023414 Css 3compartmentss Human 95% 6.368 mg/L 7.128 mg/L 0.89337822671156 +DTXSID4023416 Css 3compartmentss Human 95% 35.99 mg/L 8.733 mg/L 4.12114966220085 +DTXSID4023418 Css 3compartmentss Human 95% 2.133 mg/L NA NA NA +DTXSID4023460 Css 3compartmentss Human 95% 0.3776 mg/L 0.07687 mg/L 4.91218941069338 +DTXSID4023462 Css 3compartmentss Human 95% 0.7566 mg/L 1.623 mg/L 0.466173752310536 +DTXSID4023541 Css 3compartmentss Human 95% 4.503 mg/L 3.082 mg/L 1.4610642439974 +DTXSID4023545 Css 3compartmentss Human 95% 8.75 mg/L 40.86 mg/L 0.2141458639256 +DTXSID4023549 Css 3compartmentss Human 95% 2.603 mg/L 3.436 mg/L 0.757566938300349 +DTXSID4023591 Css 3compartmentss Human 95% 7.034 mg/L 1.438 mg/L 4.89151599443672 +DTXSID4023593 Css 3compartmentss Human 95% 6.026 mg/L 6.331 mg/L 0.95182435634181 +DTXSID4023595 Css 3compartmentss Human 95% 18.57 mg/L 0.04885 mg/L 380.14329580348 +DTXSID4023620 Css 3compartmentss Human 95% 2.791 mg/L 0.4397 mg/L 6.34750966568115 +DTXSID4023622 Css 3compartmentss Human 95% 8.474 mg/L 2.013 mg/L 4.20963735717834 +DTXSID4023624 Css 3compartmentss Human 95% 15.89 mg/L 536.5 mg/L 0.0296178937558248 +DTXSID4023626 Css 3compartmentss Human 95% 1.206 mg/L 1.807 mg/L 0.667404537908135 +DTXSID4023628 Css 3compartmentss Human 95% 0.8439 mg/L 1.08 mg/L 0.781388888888889 +DTXSID40236689 Css 3compartmentss Human 95% 85.83 mg/L NA NA NA +DTXSID4023670 Css 3compartmentss Human 95% 13.45 mg/L 377.7 mg/L 0.0356102727032036 +DTXSID4023674 Css 3compartmentss Human 95% 1.113 mg/L 1.412 mg/L 0.788243626062323 +DTXSID4023676 Css 3compartmentss Human 95% 5.902 mg/L 4.099 mg/L 1.43986338131252 +DTXSID4023678 Css 3compartmentss Human 95% 6.566 mg/L 1.159 mg/L 5.66522864538395 +DTXSID4023705 Css 3compartmentss Human 95% 0.7708 mg/L NA NA NA +DTXSID4023753 Css 3compartmentss Human 95% 130.9 mg/L 176.4 mg/L 0.742063492063492 +DTXSID40238163 Css 3compartmentss Human 95% 1.135 mg/L NA NA NA +DTXSID40238527 Css 3compartmentss Human 95% 30.98 mg/L NA NA NA +DTXSID4023917 Css 3compartmentss Human 95% 0.3449 mg/L NA NA NA +DTXSID4024018 Css 3compartmentss Human 95% 14.97 mg/L 15.52 mg/L 0.964561855670103 +DTXSID4024062 Css 3compartmentss Human 95% 0.6868 mg/L 1.67 mg/L 0.41125748502994 +DTXSID4024064 Css 3compartmentss Human 95% 19.52 mg/L 221.3 mg/L 0.0882060551287844 +DTXSID4024066 Css 3compartmentss Human 95% 3.119 mg/L 3.219 mg/L 0.968934451693072 +DTXSID4024143 Css 3compartmentss Human 95% 7.365 mg/L 1.858 mg/L 3.96393972012917 +DTXSID4024145 Css 3compartmentss Human 95% 1.033 mg/L 1.02 mg/L 1.01274509803922 +DTXSID4024193 Css 3compartmentss Human 95% 3.155 mg/L 59.04 mg/L 0.0534383468834688 +DTXSID4024195 Css 3compartmentss Human 95% 159 mg/L 305.2 mg/L 0.520969855832241 +DTXSID4024222 Css 3compartmentss Human 95% 4.209 mg/L 5.125 mg/L 0.821268292682927 +DTXSID4024270 Css 3compartmentss Human 95% 15.53 mg/L 15.15 mg/L 1.02508250825083 +DTXSID4024272 Css 3compartmentss Human 95% 6.126 mg/L 2.332 mg/L 2.62692967409949 +DTXSID4024274 Css 3compartmentss Human 95% 0.1368 mg/L 0.1415 mg/L 0.96678445229682 +DTXSID4024276 Css 3compartmentss Human 95% 15.03 mg/L 15.75 mg/L 0.954285714285714 +DTXSID4024303 Css 3compartmentss Human 95% 6.174 mg/L 7.102 mg/L 0.869332582371163 +DTXSID4024359 Css 3compartmentss Human 95% 31.42 mg/L 31.02 mg/L 1.01289490651193 +DTXSID4024436 Css 3compartmentss Human 95% 150.8 mg/L 266.2 mg/L 0.56649135987979 +DTXSID4024484 Css 3compartmentss Human 95% 0.6586 mg/L 0.2419 mg/L 2.72261264985531 +DTXSID4024488 Css 3compartmentss Human 95% 0.349 mg/L 0.2754 mg/L 1.26724763979666 +DTXSID4024642 Css 3compartmentss Human 95% 6.34 mg/L 7.581 mg/L 0.836301279514576 +DTXSID4024644 Css 3compartmentss Human 95% 7.944 mg/L 9.312 mg/L 0.853092783505155 +DTXSID4024646 Css 3compartmentss Human 95% 8.548 mg/L 2.859 mg/L 2.98985659321441 +DTXSID4024692 Css 3compartmentss Human 95% 6.712 mg/L NA NA NA +DTXSID4024721 Css 3compartmentss Human 95% 0.7141 mg/L NA NA NA +DTXSID4024729 Css 3compartmentss Human 95% 0.2531 mg/L 0.3151 mg/L 0.803237067597588 +DTXSID4024771 Css 3compartmentss Human 95% 1.278 mg/L 46.55 mg/L 0.0274543501611171 +DTXSID4024800 Css 3compartmentss Human 95% 0.8904 mg/L 0.9329 mg/L 0.954443134312359 +DTXSID4024931 Css 3compartmentss Human 95% 0.2298 mg/L 0.1469 mg/L 1.5643294758339 +DTXSID4024937 Css 3compartmentss Human 95% 12 mg/L 12.08 mg/L 0.993377483443709 +DTXSID4024981 Css 3compartmentss Human 95% 79.77 mg/L 87.2 mg/L 0.914793577981651 +DTXSID4024985 Css 3compartmentss Human 95% 7.176 mg/L NA NA NA +DTXSID4025113 Css 3compartmentss Human 95% 0.2208 mg/L 0.2479 mg/L 0.890681726502622 +DTXSID4025165 Css 3compartmentss Human 95% 6.67 mg/L 41.11 mg/L 0.162247628314279 +DTXSID4025167 Css 3compartmentss Human 95% 7.186 mg/L 10.88 mg/L 0.660477941176471 +DTXSID4025292 Css 3compartmentss Human 95% 1.688 mg/L 8.094 mg/L 0.208549542871263 +DTXSID4025404 Css 3compartmentss Human 95% 18.7 mg/L 9.171 mg/L 2.03903609202922 +DTXSID4025454 Css 3compartmentss Human 95% 12.96 mg/L 2.609 mg/L 4.96742046761211 +DTXSID4025581 Css 3compartmentss Human 95% 8.588 mg/L 2.16 mg/L 3.97592592592593 +DTXSID4025587 Css 3compartmentss Human 95% 1.846 mg/L 0.6234 mg/L 2.96118062239333 +DTXSID4025610 Css 3compartmentss Human 95% 0.5091 mg/L 0.08414 mg/L 6.05062990254338 +DTXSID4025612 Css 3compartmentss Human 95% 6.973 mg/L 1.707 mg/L 4.08494434680726 +DTXSID4025660 Css 3compartmentss Human 95% 6.206 mg/L NA NA NA +DTXSID4025662 Css 3compartmentss Human 95% 1.134 mg/L 1.664 mg/L 0.681490384615385 +DTXSID4025668 Css 3compartmentss Human 95% 2.446 mg/L 0.1575 mg/L 15.5301587301587 +DTXSID4025741 Css 3compartmentss Human 95% 2.017 mg/L 2.153 mg/L 0.936832326985601 +DTXSID4025743 Css 3compartmentss Human 95% 2.222 mg/L 3.968 mg/L 0.559979838709677 +DTXSID4025745 Css 3compartmentss Human 95% 1.867 mg/L 3.671 mg/L 0.508580768183056 +DTXSID4025749 Css 3compartmentss Human 95% 7.551 mg/L 12.75 mg/L 0.592235294117647 +DTXSID4025791 Css 3compartmentss Human 95% 1.42 mg/L 1.458 mg/L 0.973936899862826 +DTXSID4025903 Css 3compartmentss Human 95% 1.728 mg/L 6.068 mg/L 0.284772577455504 +DTXSID4026000 Css 3compartmentss Human 95% 203.3 mg/L 55.33 mg/L 3.67431772998373 +DTXSID4026137 Css 3compartmentss Human 95% 17.92 mg/L 23.78 mg/L 0.753574432296047 +DTXSID4026139 Css 3compartmentss Human 95% 2.397 mg/L 2.963 mg/L 0.808977387782653 +DTXSID4026181 Css 3compartmentss Human 95% 26.2 mg/L 20.91 mg/L 1.25298900047824 +DTXSID4026183 Css 3compartmentss Human 95% 0.3522 mg/L NA NA NA +DTXSID4026212 Css 3compartmentss Human 95% 21.24 mg/L 26.05 mg/L 0.815355086372361 +DTXSID4026214 Css 3compartmentss Human 95% 69.24 mg/L 51.03 mg/L 1.35684891240447 +DTXSID4026262 Css 3compartmentss Human 95% 0.04675 mg/L 0.05112 mg/L 0.914514866979656 +DTXSID4026264 Css 3compartmentss Human 95% 20.31 mg/L NA NA NA +DTXSID4026266 Css 3compartmentss Human 95% 4.99 mg/L 5.488 mg/L 0.909256559766764 +DTXSID4026268 Css 3compartmentss Human 95% 213.2 mg/L 295.7 mg/L 0.721001014541765 +DTXSID4026422 Css 3compartmentss Human 95% 7.328 mg/L 8.515 mg/L 0.860598943041691 +DTXSID4026472 Css 3compartmentss Human 95% 2.785 mg/L 3.254 mg/L 0.855869698832207 +DTXSID4026505 Css 3compartmentss Human 95% 13.71 mg/L 1.167 mg/L 11.7480719794344 +DTXSID4026557 Css 3compartmentss Human 95% 1.031 mg/L 0.4991 mg/L 2.06571829292727 +DTXSID4026684 Css 3compartmentss Human 95% 29.04 mg/L 28.46 mg/L 1.02037947997189 +DTXSID4026713 Css 3compartmentss Human 95% 0.2573 mg/L NA NA NA +DTXSID4026921 Css 3compartmentss Human 95% 7.291 mg/L 7.607 mg/L 0.95845931378993 +DTXSID4026975 Css 3compartmentss Human 95% 9.76 mg/L 9.258 mg/L 1.05422337437892 +DTXSID4026979 Css 3compartmentss Human 95% 5.745 mg/L 5.874 mg/L 0.978038815117467 +DTXSID4027072 Css 3compartmentss Human 95% 0.8676 mg/L 0.8524 mg/L 1.01783200375411 +DTXSID4027076 Css 3compartmentss Human 95% 0.8338 mg/L 74.8 mg/L 0.0111470588235294 +DTXSID4027109 Css 3compartmentss Human 95% 6.572 mg/L 0.04695 mg/L 139.978700745474 +DTXSID4027159 Css 3compartmentss Human 95% 6.662 mg/L 5.002 mg/L 1.33186725309876 +DTXSID4027236 Css 3compartmentss Human 95% 0.4244 mg/L 1.829 mg/L 0.232039365773647 +DTXSID4027280 Css 3compartmentss Human 95% 11.91 mg/L 7.171 mg/L 1.66085622646772 +DTXSID4027282 Css 3compartmentss Human 95% 9.643 mg/L NA NA NA +DTXSID4027284 Css 3compartmentss Human 95% 5.552 mg/L 6.19 mg/L 0.896930533117932 +DTXSID4027286 Css 3compartmentss Human 95% 0.3742 mg/L 38.57 mg/L 0.00970184080891885 +DTXSID4027319 Css 3compartmentss Human 95% 0.3507 mg/L 1.275 mg/L 0.275058823529412 +DTXSID4027361 Css 3compartmentss Human 95% 5.679 mg/L 7.902 mg/L 0.718678815489749 +DTXSID4027494 Css 3compartmentss Human 95% 0.3478 mg/L 0.3633 mg/L 0.957335535370217 +DTXSID4027496 Css 3compartmentss Human 95% 71.87 mg/L 31.11 mg/L 2.31018964963034 +DTXSID4027498 Css 3compartmentss Human 95% 1.376 mg/L 28.12 mg/L 0.0489331436699858 +DTXSID4027521 Css 3compartmentss Human 95% 1.721 mg/L 1.188 mg/L 1.4486531986532 +DTXSID4027525 Css 3compartmentss Human 95% 7.384 mg/L 11.38 mg/L 0.648857644991213 +DTXSID4027527 Css 3compartmentss Human 95% 242.1 mg/L NA NA NA +DTXSID4027529 Css 3compartmentss Human 95% 6.649 mg/L 6.778 mg/L 0.980967837120094 +DTXSID4027577 Css 3compartmentss Human 95% 7.535 mg/L 8.785 mg/L 0.857712009106431 +DTXSID4027579 Css 3compartmentss Human 95% 6.893 mg/L 5.77 mg/L 1.1946273830156 +DTXSID4027600 Css 3compartmentss Human 95% 6.031 mg/L 9.584 mg/L 0.62927796327212 +DTXSID4027604 Css 3compartmentss Human 95% 155.9 mg/L 162.9 mg/L 0.957028852056476 +DTXSID4027608 Css 3compartmentss Human 95% 11.9 mg/L 2.707 mg/L 4.39601034355375 +DTXSID4027652 Css 3compartmentss Human 95% 7.141 mg/L 8.257 mg/L 0.864841952282911 +DTXSID4027656 Css 3compartmentss Human 95% 11.91 mg/L 10.01 mg/L 1.18981018981019 +DTXSID4027658 Css 3compartmentss Human 95% 4.669 mg/L NA NA NA +DTXSID4027781 Css 3compartmentss Human 95% 20.71 mg/L NA NA NA +DTXSID4027789 Css 3compartmentss Human 95% 7.856 mg/L 5.044 mg/L 1.55749405233941 +DTXSID4027997 Css 3compartmentss Human 95% 0.4157 mg/L 2.529 mg/L 0.16437327006722 +DTXSID4028040 Css 3compartmentss Human 95% 5.627 mg/L 7.271 mg/L 0.773896300371338 +DTXSID40284160 Css 3compartmentss Human 95% 1.307 mg/L NA NA NA +DTXSID4029145 Css 3compartmentss Human 95% 0.242 mg/L 2.752 mg/L 0.0879360465116279 +DTXSID4029195 Css 3compartmentss Human 95% 7.146 mg/L 1.266 mg/L 5.64454976303317 +DTXSID4029220 Css 3compartmentss Human 95% 0.2449 mg/L 0.5925 mg/L 0.413333333333333 +DTXSID4029224 Css 3compartmentss Human 95% 4.957 mg/L 5.674 mg/L 0.873634120549877 +DTXSID4029270 Css 3compartmentss Human 95% 4.867 mg/L NA NA NA +DTXSID4029353 Css 3compartmentss Human 95% 20.99 mg/L NA NA NA +DTXSID4029359 Css 3compartmentss Human 95% 7.906 mg/L 3.266 mg/L 2.4206981016534 +DTXSID4030047 Css 3compartmentss Human 95% 889.2 mg/L NA NA NA +DTXSID4030384 Css 3compartmentss Human 95% 2.873 mg/L 2.423 mg/L 1.18572018159307 +DTXSID4031356 Css 3compartmentss Human 95% 5.155 mg/L 6.404 mg/L 0.804965646470956 +DTXSID4031566 Css 3compartmentss Human 95% 0.4333 mg/L 1.024 mg/L 0.42314453125 +DTXSID4031980 Css 3compartmentss Human 95% 12.69 mg/L 12.12 mg/L 1.0470297029703 +DTXSID4032372 Css 3compartmentss Human 95% 7.983 mg/L 7.968 mg/L 1.00188253012048 +DTXSID4032374 Css 3compartmentss Human 95% 20.67 mg/L 89.02 mg/L 0.232195012356774 +DTXSID4032376 Css 3compartmentss Human 95% 0.5832 mg/L 0.6687 mg/L 0.8721399730821 +DTXSID4032378 Css 3compartmentss Human 95% 26.33 mg/L 137 mg/L 0.192189781021898 +DTXSID4032405 Css 3compartmentss Human 95% 0.3457 mg/L 0.4121 mg/L 0.838874059694249 +DTXSID4032459 Css 3compartmentss Human 95% 570.4 mg/L 596.8 mg/L 0.955764075067024 +DTXSID4032532 Css 3compartmentss Human 95% 0.05902 mg/L 0.3526 mg/L 0.167385138967669 +DTXSID4032536 Css 3compartmentss Human 95% 17.29 mg/L 6.068 mg/L 2.84937376400791 +DTXSID4032580 Css 3compartmentss Human 95% 0.8887 mg/L 1.021 mg/L 0.870421155729677 +DTXSID4032611 Css 3compartmentss Human 95% 3.161 mg/L 4.364 mg/L 0.724335472043996 +DTXSID4032613 Css 3compartmentss Human 95% 10.08 mg/L 10.21 mg/L 0.987267384916748 +DTXSID4032615 Css 3compartmentss Human 95% 29.34 mg/L 47.18 mg/L 0.621873675286138 +DTXSID4032619 Css 3compartmentss Human 95% 9.273 mg/L 20.14 mg/L 0.460427010923535 +DTXSID4032954 Css 3compartmentss Human 95% 6.843 mg/L 8.184 mg/L 0.836143695014663 +DTXSID40332791 Css 3compartmentss Human 95% 3.832 mg/L NA NA NA +DTXSID4033390 Css 3compartmentss Human 95% 2.544 mg/L 3.159 mg/L 0.805318138651472 +DTXSID40338233 Css 3compartmentss Human 95% 0.2386 mg/L NA NA NA +DTXSID40340795 Css 3compartmentss Human 95% 1.209 mg/L NA NA NA +DTXSID4034102 Css 3compartmentss Human 95% 2.121 mg/L 1.127 mg/L 1.88198757763975 +DTXSID4034150 Css 3compartmentss Human 95% 0.4093 mg/L 0.4112 mg/L 0.995379377431907 +DTXSID4034287 Css 3compartmentss Human 95% 7.533 mg/L 6.947 mg/L 1.08435295811142 +DTXSID4034364 Css 3compartmentss Human 95% 16.44 mg/L 18.68 mg/L 0.880085653104925 +DTXSID4034497 Css 3compartmentss Human 95% 12.05 mg/L 12.04 mg/L 1.00083056478405 +DTXSID4034528 Css 3compartmentss Human 95% 178.4 mg/L 204.6 mg/L 0.871945259042033 +DTXSID40345609 Css 3compartmentss Human 95% 20.04 mg/L NA NA NA +DTXSID4034576 Css 3compartmentss Human 95% 1.795 mg/L 10.37 mg/L 0.173095467695275 +DTXSID4034601 Css 3compartmentss Human 95% 11.76 mg/L 5.668 mg/L 2.07480592801694 +DTXSID4034609 Css 3compartmentss Human 95% 163.5 mg/L 163 mg/L 1.00306748466258 +DTXSID4034653 Css 3compartmentss Human 95% 8.363 mg/L 10.52 mg/L 0.794961977186312 +DTXSID4034788 Css 3compartmentss Human 95% 3.401 mg/L 1.318 mg/L 2.5804248861912 +DTXSID4034869 Css 3compartmentss Human 95% 1.354 mg/L 70.36 mg/L 0.0192438885730529 +DTXSID4034948 Css 3compartmentss Human 95% 9.466 mg/L 9.497 mg/L 0.996735811308834 +DTXSID40351068 Css 3compartmentss Human 95% 3.157 mg/L NA NA NA +DTXSID4035209 Css 3compartmentss Human 95% 8.063 mg/L 5.276 mg/L 1.52824109173616 +DTXSID4035839 Css 3compartmentss Human 95% 7.158 mg/L NA NA NA +DTXSID4036229 Css 3compartmentss Human 95% 12.86 mg/L 5.188 mg/L 2.47879722436392 +DTXSID4036435 Css 3compartmentss Human 95% 4.618 mg/L NA NA NA +DTXSID4036489 Css 3compartmentss Human 95% 2.944 mg/L 4.05 mg/L 0.726913580246914 +DTXSID4037168 Css 3compartmentss Human 95% 9.174 mg/L NA NA NA +DTXSID4037580 Css 3compartmentss Human 95% 5.604 mg/L 0.007955 mg/L 704.462602137021 +DTXSID4037582 Css 3compartmentss Human 95% 0.3528 mg/L 0.8318 mg/L 0.4241404183698 +DTXSID4037584 Css 3compartmentss Human 95% 17.96 mg/L 42.38 mg/L 0.423784804152902 +DTXSID4037611 Css 3compartmentss Human 95% 16.84 mg/L NA NA NA +DTXSID4037617 Css 3compartmentss Human 95% 1.435 mg/L 0.6223 mg/L 2.30596175478065 +DTXSID4038762 Css 3compartmentss Human 95% 8.62 mg/L 1.112 mg/L 7.75179856115108 +DTXSID4038845 Css 3compartmentss Human 95% 0.3489 mg/L NA NA NA +DTXSID4038847 Css 3compartmentss Human 95% 7.827 mg/L 1.008 mg/L 7.76488095238095 +DTXSID4038899 Css 3compartmentss Human 95% 275.7 mg/L 7.793 mg/L 35.3779032465033 +DTXSID4038922 Css 3compartmentss Human 95% 20.16 mg/L 57.99 mg/L 0.347646145887222 +DTXSID4038926 Css 3compartmentss Human 95% 4.202 mg/L 3.841 mg/L 1.09398594116116 +DTXSID4039235 Css 3compartmentss Human 95% 4.053 mg/L 47.08 mg/L 0.0860875106202209 +DTXSID4039657 Css 3compartmentss Human 95% 3.583 mg/L 6.266 mg/L 0.571816150654325 +DTXSID4040002 Css 3compartmentss Human 95% 13.31 mg/L 13.83 mg/L 0.962400578452639 +DTXSID4040137 Css 3compartmentss Human 95% 0.2764 mg/L NA NA NA +DTXSID4040187 Css 3compartmentss Human 95% 4.585 mg/L 5.085 mg/L 0.901671583087512 +DTXSID4040264 Css 3compartmentss Human 95% 1729 mg/L 1933 mg/L 0.894464562855665 +DTXSID4040266 Css 3compartmentss Human 95% 5.083 mg/L 10.53 mg/L 0.482716049382716 +DTXSID4040268 Css 3compartmentss Human 95% 5.087 mg/L 0.5209 mg/L 9.7657899788827 +DTXSID4040343 Css 3compartmentss Human 95% 1.373 mg/L 11.48 mg/L 0.119599303135888 +DTXSID4040395 Css 3compartmentss Human 95% 0.3683 mg/L 0.2507 mg/L 1.46908655763861 +DTXSID4040476 Css 3compartmentss Human 95% 21.11 mg/L 7.155 mg/L 2.95038434661076 +DTXSID4040680 Css 3compartmentss Human 95% 8.935 mg/L NA NA NA +DTXSID4040682 Css 3compartmentss Human 95% 5.292 mg/L 10.22 mg/L 0.517808219178082 +DTXSID4040684 Css 3compartmentss Human 95% 6.22 mg/L 0.5037 mg/L 12.3486202104427 +DTXSID4040686 Css 3compartmentss Human 95% 74.74 mg/L 109.1 mg/L 0.685059578368469 +DTXSID4040711 Css 3compartmentss Human 95% 1.832 mg/L 0.6097 mg/L 3.00475643759226 +DTXSID4040715 Css 3compartmentss Human 95% 1.003 mg/L 0.5914 mg/L 1.69597565099763 +DTXSID4040719 Css 3compartmentss Human 95% 0.5375 mg/L 1.824 mg/L 0.29468201754386 +DTXSID4040761 Css 3compartmentss Human 95% 42.79 mg/L NA NA NA +DTXSID4040763 Css 3compartmentss Human 95% 7.784 mg/L NA NA NA +DTXSID4040765 Css 3compartmentss Human 95% 0.2925 mg/L 0.01012 mg/L 28.903162055336 +DTXSID4040767 Css 3compartmentss Human 95% 13540 mg/L 13950 mg/L 0.970609318996416 +DTXSID4040979 Css 3compartmentss Human 95% 2.205 mg/L 0.7459 mg/L 2.95616034320955 +DTXSID4041070 Css 3compartmentss Human 95% 21.26 mg/L 18.72 mg/L 1.13568376068376 +DTXSID4041155 Css 3compartmentss Human 95% 2.05 mg/L NA NA NA +DTXSID4041230 Css 3compartmentss Human 95% 7.255 mg/L 0.2849 mg/L 25.4650754650755 +DTXSID4041234 Css 3compartmentss Human 95% 7.098 mg/L 2.352 mg/L 3.01785714285714 +DTXSID4041238 Css 3compartmentss Human 95% 0.2439 mg/L 0.2348 mg/L 1.03875638841567 +DTXSID4041280 Css 3compartmentss Human 95% 0.2167 mg/L 0.2183 mg/L 0.992670636738433 +DTXSID4041317 Css 3compartmentss Human 95% 87.73 mg/L NA NA NA +DTXSID4041361 Css 3compartmentss Human 95% 3.884 mg/L 5.883 mg/L 0.660207377188509 +DTXSID4041363 Css 3compartmentss Human 95% 56.56 mg/L 60.14 mg/L 0.940472231459927 +DTXSID4041367 Css 3compartmentss Human 95% 3.445 mg/L 3.635 mg/L 0.947730398899587 +DTXSID4041442 Css 3compartmentss Human 95% 1.819 mg/L 11.45 mg/L 0.158864628820961 +DTXSID4041446 Css 3compartmentss Human 95% 2.532 mg/L 3.005 mg/L 0.842595673876872 +DTXSID4041448 Css 3compartmentss Human 95% 6.814 mg/L NA NA NA +DTXSID4041490 Css 3compartmentss Human 95% 0.3138 mg/L 3.341 mg/L 0.093923974857827 +DTXSID4041494 Css 3compartmentss Human 95% 54.91 mg/L 39.08 mg/L 1.40506653019447 +DTXSID4041521 Css 3compartmentss Human 95% 6.823 mg/L 1.54 mg/L 4.43051948051948 +DTXSID4041527 Css 3compartmentss Human 95% 7.207 mg/L 1.543 mg/L 4.67077122488659 +DTXSID4041529 Css 3compartmentss Human 95% 7.489 mg/L 1.012 mg/L 7.4001976284585 +DTXSID4041573 Css 3compartmentss Human 95% 8.637 mg/L 0.1414 mg/L 61.0820367751061 +DTXSID4041575 Css 3compartmentss Human 95% 3.296 mg/L 3.868 mg/L 0.852119958634953 +DTXSID4041600 Css 3compartmentss Human 95% 2.978 mg/L 0.838 mg/L 3.55369928400955 +DTXSID4041654 Css 3compartmentss Human 95% 18.01 mg/L 12.71 mg/L 1.41699449252557 +DTXSID4041656 Css 3compartmentss Human 95% 158.8 mg/L 163 mg/L 0.974233128834356 +DTXSID4041783 Css 3compartmentss Human 95% 2.333 mg/L 1.544 mg/L 1.5110103626943 +DTXSID4041991 Css 3compartmentss Human 95% 8.211 mg/L NA NA NA +DTXSID4041995 Css 3compartmentss Human 95% 2.073 mg/L 10.13 mg/L 0.204639684106614 +DTXSID4041997 Css 3compartmentss Human 95% 0.3513 mg/L 0.4124 mg/L 0.85184287099903 +DTXSID4042090 Css 3compartmentss Human 95% 2.761 mg/L 51.63 mg/L 0.0534766608560914 +DTXSID4042094 Css 3compartmentss Human 95% 16.1 mg/L 12.27 mg/L 1.3121434392828 +DTXSID4042096 Css 3compartmentss Human 95% 5.093 mg/L 5.575 mg/L 0.913542600896861 +DTXSID4042121 Css 3compartmentss Human 95% 167.8 mg/L 172.1 mg/L 0.975014526438117 +DTXSID4042123 Css 3compartmentss Human 95% 8.56 mg/L 9.805 mg/L 0.87302396736359 +DTXSID4042171 Css 3compartmentss Human 95% 3.274 mg/L 2.973 mg/L 1.1012445341406 +DTXSID4042208 Css 3compartmentss Human 95% 2.158 mg/L 2.398 mg/L 0.899916597164304 +DTXSID4042252 Css 3compartmentss Human 95% 0.972 mg/L 0.7241 mg/L 1.3423560281729 +DTXSID4042254 Css 3compartmentss Human 95% 10.8 mg/L 630.2 mg/L 0.0171374166931133 +DTXSID4042256 Css 3compartmentss Human 95% 24.3 mg/L 36.14 mg/L 0.672385168788047 +DTXSID4042335 Css 3compartmentss Human 95% 0.321 mg/L 7.282 mg/L 0.0440812963471574 +DTXSID4042416 Css 3compartmentss Human 95% 2.157 mg/L 146.5 mg/L 0.0147235494880546 +DTXSID4042418 Css 3compartmentss Human 95% 0.8819 mg/L 6.389 mg/L 0.138034121145719 +DTXSID4042462 Css 3compartmentss Human 95% 5.016 mg/L NA NA NA +DTXSID4042468 Css 3compartmentss Human 95% 0.7242 mg/L 0.1817 mg/L 3.98569069895432 +DTXSID4042622 Css 3compartmentss Human 95% 3.887 mg/L 6.793 mg/L 0.572206683350508 +DTXSID40431319 Css 3compartmentss Human 95% 0.0748 mg/L NA NA NA +DTXSID40432386 Css 3compartmentss Human 95% 18.21 mg/L NA NA NA +DTXSID4043777 Css 3compartmentss Human 95% 1.438 mg/L 0.6736 mg/L 2.13479809976247 +DTXSID4043802 Css 3compartmentss Human 95% 3.602 mg/L 3.664 mg/L 0.983078602620087 +DTXSID4044292 Css 3compartmentss Human 95% 26.52 mg/L NA NA NA +DTXSID4044371 Css 3compartmentss Human 95% 5.82 mg/L 2.574 mg/L 2.26107226107226 +DTXSID4044373 Css 3compartmentss Human 95% 2.524 mg/L 2.823 mg/L 0.894084307474318 +DTXSID4044375 Css 3compartmentss Human 95% 5.653 mg/L 2.822 mg/L 2.00318922749823 +DTXSID4044402 Css 3compartmentss Human 95% 7.442 mg/L 1.53 mg/L 4.8640522875817 +DTXSID4044404 Css 3compartmentss Human 95% 8.332 mg/L 1.084 mg/L 7.68634686346863 +DTXSID4044408 Css 3compartmentss Human 95% 6.555 mg/L 4.283 mg/L 1.53046929722157 +DTXSID4044450 Css 3compartmentss Human 95% 0.5128 mg/L NA NA NA +DTXSID4044454 Css 3compartmentss Human 95% 0.3196 mg/L 4.777 mg/L 0.0669039145907473 +DTXSID4044456 Css 3compartmentss Human 95% 4.156 mg/L 5.076 mg/L 0.818754925137904 +DTXSID4044458 Css 3compartmentss Human 95% 6.002 mg/L 4.843 mg/L 1.23931447449928 +DTXSID4044535 Css 3compartmentss Human 95% 5.07 mg/L 90.69 mg/L 0.0559047304002646 +DTXSID4044581 Css 3compartmentss Human 95% 1.339 mg/L 1.277 mg/L 1.04855129209084 +DTXSID4044585 Css 3compartmentss Human 95% 6.294 mg/L 7.374 mg/L 0.853539462978031 +DTXSID4044587 Css 3compartmentss Human 95% 0.3937 mg/L NA NA NA +DTXSID4044589 Css 3compartmentss Human 95% 5.368 mg/L 7.406 mg/L 0.72481771536592 +DTXSID4044660 Css 3compartmentss Human 95% 1.535 mg/L 1.183 mg/L 1.29754860524091 +DTXSID4044664 Css 3compartmentss Human 95% 1.617 mg/L 1.458 mg/L 1.10905349794239 +DTXSID4044743 Css 3compartmentss Human 95% 13.74 mg/L 13.96 mg/L 0.984240687679083 +DTXSID4044747 Css 3compartmentss Human 95% 7.32 mg/L 1.962 mg/L 3.73088685015291 +DTXSID4044791 Css 3compartmentss Human 95% 1.659 mg/L NA NA NA +DTXSID4044793 Css 3compartmentss Human 95% 0.6955 mg/L 3.217 mg/L 0.216195212931302 +DTXSID4044820 Css 3compartmentss Human 95% 7.534 mg/L 1.133 mg/L 6.64960282436011 +DTXSID4044822 Css 3compartmentss Human 95% 1.805 mg/L 6.544 mg/L 0.275825183374083 +DTXSID4044870 Css 3compartmentss Human 95% 1.192 mg/L 6.168 mg/L 0.19325551232166 +DTXSID4044872 Css 3compartmentss Human 95% 4.865 mg/L 11.37 mg/L 0.427880386983289 +DTXSID4044874 Css 3compartmentss Human 95% 20.13 mg/L 0.01465 mg/L 1374.0614334471 +DTXSID4044876 Css 3compartmentss Human 95% 7.335 mg/L 5.48 mg/L 1.33850364963504 +DTXSID4044878 Css 3compartmentss Human 95% 1.877 mg/L NA NA NA +DTXSID4044901 Css 3compartmentss Human 95% 2.466 mg/L 9.156 mg/L 0.269331585845347 +DTXSID4044905 Css 3compartmentss Human 95% 8.389 mg/L 0.4224 mg/L 19.860321969697 +DTXSID4044953 Css 3compartmentss Human 95% 0.3754 mg/L 1.205 mg/L 0.311535269709544 +DTXSID4044955 Css 3compartmentss Human 95% 0.3519 mg/L 7.909 mg/L 0.0444936148691364 +DTXSID4045002 Css 3compartmentss Human 95% 2.335 mg/L 0.9215 mg/L 2.53391209983722 +DTXSID4045131 Css 3compartmentss Human 95% 0.3419 mg/L 0.06531 mg/L 5.23503291992038 +DTXSID4045133 Css 3compartmentss Human 95% 1.744 mg/L 11.48 mg/L 0.15191637630662 +DTXSID4045139 Css 3compartmentss Human 95% 7.533 mg/L 5.834 mg/L 1.29122386013027 +DTXSID4045181 Css 3compartmentss Human 95% 12.62 mg/L 3.997 mg/L 3.15736802601951 +DTXSID4045183 Css 3compartmentss Human 95% 0.7743 mg/L 3.526 mg/L 0.219597277368123 +DTXSID4045187 Css 3compartmentss Human 95% 1.409 mg/L 36.01 mg/L 0.039128019994446 +DTXSID4045189 Css 3compartmentss Human 95% 0.9134 mg/L 1.877 mg/L 0.486627597229622 +DTXSID4045210 Css 3compartmentss Human 95% 0.3738 mg/L 0.277 mg/L 1.34945848375451 +DTXSID4045216 Css 3compartmentss Human 95% 13.82 mg/L 16.74 mg/L 0.825567502986858 +DTXSID4045262 Css 3compartmentss Human 95% 7.369 mg/L 5.624 mg/L 1.3102773826458 +DTXSID4045341 Css 3compartmentss Human 95% 0.359 mg/L 0.3018 mg/L 1.1895294897283 +DTXSID4045343 Css 3compartmentss Human 95% 5.064 mg/L 9.688 mg/L 0.522708505367465 +DTXSID4045345 Css 3compartmentss Human 95% 6.682 mg/L 2.302 mg/L 2.90269331016507 +DTXSID4045347 Css 3compartmentss Human 95% 6.24 mg/L 18.59 mg/L 0.335664335664336 +DTXSID4045391 Css 3compartmentss Human 95% 5.4 mg/L 4.941 mg/L 1.09289617486339 +DTXSID4045393 Css 3compartmentss Human 95% 0.7656 mg/L 0.3345 mg/L 2.28878923766816 +DTXSID4045399 Css 3compartmentss Human 95% 0.5327 mg/L 14.62 mg/L 0.0364363885088919 +DTXSID4045420 Css 3compartmentss Human 95% 5.069 mg/L 0.7488 mg/L 6.76949786324786 +DTXSID4045422 Css 3compartmentss Human 95% 1.079 mg/L 0.08712 mg/L 12.3852157943067 +DTXSID4045424 Css 3compartmentss Human 95% 7.955 mg/L 11.78 mg/L 0.675297113752122 +DTXSID4045428 Css 3compartmentss Human 95% 8.274 mg/L 1.857 mg/L 4.45557350565428 +DTXSID4045472 Css 3compartmentss Human 95% 3.391 mg/L 1.006 mg/L 3.37077534791252 +DTXSID4045474 Css 3compartmentss Human 95% 8.121 mg/L 7.478 mg/L 1.08598555763573 +DTXSID4045476 Css 3compartmentss Human 95% 3.071 mg/L 5.524 mg/L 0.555937726285301 +DTXSID4045478 Css 3compartmentss Human 95% 0.9864 mg/L 0.06372 mg/L 15.4802259887006 +DTXSID4045551 Css 3compartmentss Human 95% 9.674 mg/L 39.69 mg/L 0.24373897707231 +DTXSID4045555 Css 3compartmentss Human 95% 5.416 mg/L 1.611 mg/L 3.3618870266915 +DTXSID4045557 Css 3compartmentss Human 95% 0.8942 mg/L 2.574 mg/L 0.347397047397047 +DTXSID4045559 Css 3compartmentss Human 95% 5.03 mg/L 1.504 mg/L 3.34441489361702 +DTXSID4045630 Css 3compartmentss Human 95% 2.771 mg/L 2.547 mg/L 1.08794660384766 +DTXSID4045632 Css 3compartmentss Human 95% 1.403 mg/L 0.3334 mg/L 4.20815836832633 +DTXSID4045636 Css 3compartmentss Human 95% 5.562 mg/L 20.34 mg/L 0.273451327433628 +DTXSID4045638 Css 3compartmentss Human 95% 0.9187 mg/L 0.1385 mg/L 6.63321299638989 +DTXSID4045680 Css 3compartmentss Human 95% 4.934 mg/L 229.7 mg/L 0.0214801915542011 +DTXSID4045682 Css 3compartmentss Human 95% 0.8399 mg/L 0.7205 mg/L 1.16571825121443 +DTXSID4045686 Css 3compartmentss Human 95% 0.8859 mg/L 0.2025 mg/L 4.37481481481481 +DTXSID4045688 Css 3compartmentss Human 95% 1.468 mg/L 1.166 mg/L 1.2590051457976 +DTXSID4045711 Css 3compartmentss Human 95% 6.199 mg/L 3.12 mg/L 1.98685897435897 +DTXSID4045763 Css 3compartmentss Human 95% 6.632 mg/L 0.8381 mg/L 7.91313685717695 +DTXSID4045765 Css 3compartmentss Human 95% 6.154 mg/L 2.363 mg/L 2.60431654676259 +DTXSID4045767 Css 3compartmentss Human 95% 2.391 mg/L 3.954 mg/L 0.604704097116844 +DTXSID4045769 Css 3compartmentss Human 95% 1.675 mg/L 32.87 mg/L 0.0509583206571342 +DTXSID4045890 Css 3compartmentss Human 95% 3.419 mg/L 0.4231 mg/L 8.08083195462066 +DTXSID4045892 Css 3compartmentss Human 95% 11.31 mg/L 12.38 mg/L 0.913570274636511 +DTXSID4045896 Css 3compartmentss Human 95% 2.115 mg/L 1.213 mg/L 1.74361088211047 +DTXSID4045898 Css 3compartmentss Human 95% 3.517 mg/L 10.76 mg/L 0.32685873605948 +DTXSID4045921 Css 3compartmentss Human 95% 0.8883 mg/L 1.829 mg/L 0.485675232367414 +DTXSID4045925 Css 3compartmentss Human 95% 3.789 mg/L 6.452 mg/L 0.587259764414135 +DTXSID4045927 Css 3compartmentss Human 95% 2.17 mg/L 21.22 mg/L 0.102262016965127 +DTXSID4045929 Css 3compartmentss Human 95% 8.706 mg/L 8.447 mg/L 1.03066177341068 +DTXSID4045973 Css 3compartmentss Human 95% 3.208 mg/L 4.515 mg/L 0.710520487264673 +DTXSID4045975 Css 3compartmentss Human 95% 28.27 mg/L 9.739 mg/L 2.90276209056371 +DTXSID4045979 Css 3compartmentss Human 95% 5.039 mg/L 5.553 mg/L 0.907437421213758 +DTXSID4046020 Css 3compartmentss Human 95% 8.056 mg/L 0.4784 mg/L 16.8394648829431 +DTXSID4046022 Css 3compartmentss Human 95% 3.214 mg/L 3.373 mg/L 0.952860954639786 +DTXSID4046024 Css 3compartmentss Human 95% 0.5697 mg/L 11.49 mg/L 0.0495822454308094 +DTXSID4046076 Css 3compartmentss Human 95% 0.7972 mg/L 1.956 mg/L 0.407566462167689 +DTXSID4046078 Css 3compartmentss Human 95% 0.8629 mg/L 0.09334 mg/L 9.2446968073709 +DTXSID4046101 Css 3compartmentss Human 95% 7.72 mg/L 49.01 mg/L 0.157518873699245 +DTXSID4046103 Css 3compartmentss Human 95% 3.186 mg/L 65.46 mg/L 0.0486709440879927 +DTXSID4046107 Css 3compartmentss Human 95% 7.345 mg/L 0.7727 mg/L 9.50562961045684 +DTXSID4046109 Css 3compartmentss Human 95% 2.483 mg/L 4.43 mg/L 0.560496613995485 +DTXSID4046151 Css 3compartmentss Human 95% 34.1 mg/L 1003 mg/L 0.0339980059820538 +DTXSID4046153 Css 3compartmentss Human 95% 7.026 mg/L 10.05 mg/L 0.69910447761194 +DTXSID4046155 Css 3compartmentss Human 95% 4.923 mg/L 94.98 mg/L 0.0518319646241314 +DTXSID4046157 Css 3compartmentss Human 95% 6.235 mg/L 393 mg/L 0.0158651399491094 +DTXSID4046159 Css 3compartmentss Human 95% 6.239 mg/L 1.355 mg/L 4.60442804428044 +DTXSID4046230 Css 3compartmentss Human 95% 5.283 mg/L 2.145 mg/L 2.46293706293706 +DTXSID4046232 Css 3compartmentss Human 95% 1.86 mg/L 0.2892 mg/L 6.43153526970954 +DTXSID4046234 Css 3compartmentss Human 95% 1.811 mg/L 6.39 mg/L 0.283411580594679 +DTXSID4046236 Css 3compartmentss Human 95% 30.45 mg/L 1.948 mg/L 15.6314168377823 +DTXSID4046238 Css 3compartmentss Human 95% 0.8565 mg/L NA NA NA +DTXSID4046280 Css 3compartmentss Human 95% 12.16 mg/L 5.075 mg/L 2.39605911330049 +DTXSID4046282 Css 3compartmentss Human 95% 5.439 mg/L 170.8 mg/L 0.031844262295082 +DTXSID4046284 Css 3compartmentss Human 95% 10.57 mg/L 54.77 mg/L 0.192988862515976 +DTXSID4046286 Css 3compartmentss Human 95% 1.698 mg/L 11.39 mg/L 0.149078138718174 +DTXSID4046288 Css 3compartmentss Human 95% 8.504 mg/L 2.029 mg/L 4.19122720551996 +DTXSID4046313 Css 3compartmentss Human 95% 0.3208 mg/L 0.3248 mg/L 0.987684729064039 +DTXSID4046315 Css 3compartmentss Human 95% 0.8693 mg/L 3.81 mg/L 0.228162729658793 +DTXSID4046319 Css 3compartmentss Human 95% 0.05705 mg/L 0.06309 mg/L 0.90426375019813 +DTXSID4046361 Css 3compartmentss Human 95% 9.299 mg/L 0.1688 mg/L 55.0888625592417 +DTXSID4046363 Css 3compartmentss Human 95% 85.93 mg/L 99.6 mg/L 0.862751004016064 +DTXSID4046440 Css 3compartmentss Human 95% 6.484 mg/L 5.571 mg/L 1.16388440136421 +DTXSID4046442 Css 3compartmentss Human 95% 1.308 mg/L 2.206 mg/L 0.592928377153219 +DTXSID4046444 Css 3compartmentss Human 95% 7.083 mg/L 7.333 mg/L 0.965907541251875 +DTXSID4046446 Css 3compartmentss Human 95% 3.639 mg/L 5.641 mg/L 0.645098386810849 +DTXSID4046448 Css 3compartmentss Human 95% 12.81 mg/L 57.79 mg/L 0.221664647862952 +DTXSID4046490 Css 3compartmentss Human 95% 0.3652 mg/L 0.387 mg/L 0.943669250645995 +DTXSID4046492 Css 3compartmentss Human 95% 1.913 mg/L 0.2262 mg/L 8.45711759504863 +DTXSID4046494 Css 3compartmentss Human 95% 15.84 mg/L 20.69 mg/L 0.765587240212663 +DTXSID4046498 Css 3compartmentss Human 95% 10.74 mg/L 28.18 mg/L 0.381121362668559 +DTXSID4046521 Css 3compartmentss Human 95% 3.986 mg/L 28.21 mg/L 0.141297412265154 +DTXSID4046523 Css 3compartmentss Human 95% 7.571 mg/L 10.94 mg/L 0.692047531992687 +DTXSID4046525 Css 3compartmentss Human 95% 0.3746 mg/L 0.5022 mg/L 0.745917960971724 +DTXSID4046527 Css 3compartmentss Human 95% 6.689 mg/L 4.759 mg/L 1.40554738390418 +DTXSID4046529 Css 3compartmentss Human 95% 0.1797 mg/L 0.286 mg/L 0.628321678321678 +DTXSID4046571 Css 3compartmentss Human 95% 1.087 mg/L 6.157 mg/L 0.176547019652428 +DTXSID4046573 Css 3compartmentss Human 95% 73.03 mg/L 75.69 mg/L 0.964856652133703 +DTXSID4046575 Css 3compartmentss Human 95% 7.537 mg/L 8.982 mg/L 0.839122689824093 +DTXSID4046577 Css 3compartmentss Human 95% 1.429 mg/L 49.04 mg/L 0.0291394779771615 +DTXSID4046579 Css 3compartmentss Human 95% 5.096 mg/L 0.5073 mg/L 10.0453380642618 +DTXSID4046600 Css 3compartmentss Human 95% 7.328 mg/L 0.6979 mg/L 10.5000716435019 +DTXSID4046602 Css 3compartmentss Human 95% 6.41 mg/L 5.183 mg/L 1.23673548138144 +DTXSID4046604 Css 3compartmentss Human 95% 0.7275 mg/L 5.011 mg/L 0.145180602674117 +DTXSID4046608 Css 3compartmentss Human 95% 2.529 mg/L 0.788 mg/L 3.20939086294416 +DTXSID4046652 Css 3compartmentss Human 95% 0.2819 mg/L 0.2757 mg/L 1.02248821182445 +DTXSID4046654 Css 3compartmentss Human 95% 4.577 mg/L 2.306 mg/L 1.98482220294883 +DTXSID4046656 Css 3compartmentss Human 95% 5.189 mg/L 0.09796 mg/L 52.970600244998 +DTXSID4046658 Css 3compartmentss Human 95% 0.7052 mg/L 0.8218 mg/L 0.858116330007301 +DTXSID4046733 Css 3compartmentss Human 95% 1 mg/L 0.3359 mg/L 2.97707651086633 +DTXSID4046737 Css 3compartmentss Human 95% 2.178 mg/L 22.67 mg/L 0.0960741067490075 +DTXSID4046739 Css 3compartmentss Human 95% 0.3521 mg/L 0.09303 mg/L 3.78480060195636 +DTXSID4046783 Css 3compartmentss Human 95% 4.2 mg/L 7.054 mg/L 0.595406861355259 +DTXSID4046785 Css 3compartmentss Human 95% 0.8927 mg/L 0.3003 mg/L 2.97269397269397 +DTXSID4046787 Css 3compartmentss Human 95% 6.625 mg/L 148.9 mg/L 0.0444929482874412 +DTXSID4046810 Css 3compartmentss Human 95% 2.773 mg/L 7.449 mg/L 0.372264733521278 +DTXSID4046812 Css 3compartmentss Human 95% 20.27 mg/L 45.32 mg/L 0.447263901147396 +DTXSID4046814 Css 3compartmentss Human 95% 6.333 mg/L 8.313 mg/L 0.761818837964634 +DTXSID4046816 Css 3compartmentss Human 95% 132.2 mg/L 2444 mg/L 0.0540916530278232 +DTXSID4046818 Css 3compartmentss Human 95% 1.765 mg/L 1.851 mg/L 0.953538627768774 +DTXSID4046862 Css 3compartmentss Human 95% 1.739 mg/L 0.7889 mg/L 2.20433515020915 +DTXSID4046864 Css 3compartmentss Human 95% 6.711 mg/L 7.424 mg/L 0.903960129310345 +DTXSID4046866 Css 3compartmentss Human 95% 8.582 mg/L 10.31 mg/L 0.832395732298739 +DTXSID4046868 Css 3compartmentss Human 95% 9.052 mg/L 0.1817 mg/L 49.8183819482664 +DTXSID4046943 Css 3compartmentss Human 95% 0.6149 mg/L NA NA NA +DTXSID4046947 Css 3compartmentss Human 95% 2.028 mg/L NA NA NA +DTXSID4046949 Css 3compartmentss Human 95% 2.428 mg/L 30.7 mg/L 0.0790879478827362 +DTXSID4046991 Css 3compartmentss Human 95% 4.832 mg/L 7.897 mg/L 0.611877928327213 +DTXSID4046999 Css 3compartmentss Human 95% 7.978 mg/L 15.18 mg/L 0.525559947299078 +DTXSID4047042 Css 3compartmentss Human 95% 15.27 mg/L NA NA NA +DTXSID4047090 Css 3compartmentss Human 95% 1.548 mg/L 3.202 mg/L 0.483447845096814 +DTXSID4047092 Css 3compartmentss Human 95% 1.61 mg/L NA NA NA +DTXSID4047094 Css 3compartmentss Human 95% 0.5582 mg/L 3.402 mg/L 0.164079952968842 +DTXSID4047096 Css 3compartmentss Human 95% 1.286 mg/L 1.415 mg/L 0.908833922261484 +DTXSID4047098 Css 3compartmentss Human 95% 0.6678 mg/L NA NA NA +DTXSID4047121 Css 3compartmentss Human 95% 1.817 mg/L 0.9766 mg/L 1.86053655539627 +DTXSID4047129 Css 3compartmentss Human 95% 5.593 mg/L NA NA NA +DTXSID4047173 Css 3compartmentss Human 95% 3.001 mg/L 2.315 mg/L 1.2963282937365 +DTXSID4047200 Css 3compartmentss Human 95% 9.979 mg/L NA NA NA +DTXSID4047206 Css 3compartmentss Human 95% 0.7327 mg/L NA NA NA +DTXSID4047252 Css 3compartmentss Human 95% 30.29 mg/L 43.61 mg/L 0.694565466636093 +DTXSID4047254 Css 3compartmentss Human 95% 2.562 mg/L 2.937 mg/L 0.872318692543412 +DTXSID4047258 Css 3compartmentss Human 95% 69.88 mg/L 1.125 mg/L 62.1155555555556 +DTXSID4047331 Css 3compartmentss Human 95% 17.91 mg/L 7780 mg/L 0.00230205655526992 +DTXSID4047333 Css 3compartmentss Human 95% 20.97 mg/L 238.2 mg/L 0.0880352644836272 +DTXSID4047335 Css 3compartmentss Human 95% 1.453 mg/L 3.705 mg/L 0.392172739541161 +DTXSID4047337 Css 3compartmentss Human 95% 13.55 mg/L 74.21 mg/L 0.182589947446436 +DTXSID4047339 Css 3compartmentss Human 95% 9.745 mg/L 2.595 mg/L 3.75529865125241 +DTXSID4047381 Css 3compartmentss Human 95% 2.754 mg/L 3.419 mg/L 0.80549868382568 +DTXSID4047383 Css 3compartmentss Human 95% 2.796 mg/L NA NA NA +DTXSID4047385 Css 3compartmentss Human 95% 1.423 mg/L 1.028 mg/L 1.38424124513619 +DTXSID4047387 Css 3compartmentss Human 95% 2.191 mg/L 5.838 mg/L 0.375299760191846 +DTXSID4047389 Css 3compartmentss Human 95% 11.21 mg/L 280.4 mg/L 0.0399786019971469 +DTXSID4047410 Css 3compartmentss Human 95% 14.46 mg/L 11.46 mg/L 1.26178010471204 +DTXSID4047412 Css 3compartmentss Human 95% 1.545 mg/L 0.4695 mg/L 3.29073482428115 +DTXSID4047418 Css 3compartmentss Human 95% 0.9165 mg/L NA NA NA +DTXSID4047464 Css 3compartmentss Human 95% 7.257 mg/L 3.429 mg/L 2.11636045494313 +DTXSID4047466 Css 3compartmentss Human 95% 5.45 mg/L 3.305 mg/L 1.64901664145234 +DTXSID4047468 Css 3compartmentss Human 95% 9.841 mg/L 2.572 mg/L 3.82620528771384 +DTXSID4047543 Css 3compartmentss Human 95% 1.784 mg/L 4.655 mg/L 0.383243823845328 +DTXSID4047545 Css 3compartmentss Human 95% 5.981 mg/L 106.7 mg/L 0.0560543580131209 +DTXSID4047547 Css 3compartmentss Human 95% 1.93 mg/L 1.564 mg/L 1.23401534526854 +DTXSID4047549 Css 3compartmentss Human 95% 7.476 mg/L 5.087 mg/L 1.46962846471398 +DTXSID4047591 Css 3compartmentss Human 95% 18.44 mg/L NA NA NA +DTXSID4047620 Css 3compartmentss Human 95% 5.873 mg/L 1.655 mg/L 3.54864048338369 +DTXSID4047622 Css 3compartmentss Human 95% 5.386 mg/L 16.36 mg/L 0.32921760391198 +DTXSID4047670 Css 3compartmentss Human 95% 7.003 mg/L 0.5592 mg/L 12.5232474964235 +DTXSID4047672 Css 3compartmentss Human 95% 15.35 mg/L 6.889 mg/L 2.22818986790536 +DTXSID4047674 Css 3compartmentss Human 95% 0.2958 mg/L 6.269 mg/L 0.0471845589408199 +DTXSID4047678 Css 3compartmentss Human 95% 0.3513 mg/L 1.38 mg/L 0.254565217391304 +DTXSID4047703 Css 3compartmentss Human 95% 0.5472 mg/L 1.475 mg/L 0.370983050847458 +DTXSID4047705 Css 3compartmentss Human 95% 8.529 mg/L 4.17 mg/L 2.04532374100719 +DTXSID4047838 Css 3compartmentss Human 95% 1.384 mg/L 2.36 mg/L 0.586440677966102 +DTXSID4047880 Css 3compartmentss Human 95% 6.647 mg/L 3.476 mg/L 1.91225546605293 +DTXSID4047882 Css 3compartmentss Human 95% 0.1263 mg/L 0.1327 mg/L 0.951770911831198 +DTXSID4047886 Css 3compartmentss Human 95% 3.104 mg/L 1.059 mg/L 2.93106704438149 +DTXSID4047963 Css 3compartmentss Human 95% 19.44 mg/L 68.67 mg/L 0.283093053735256 +DTXSID4047969 Css 3compartmentss Human 95% 11.1 mg/L 24.16 mg/L 0.459437086092715 +DTXSID4048191 Css 3compartmentss Human 95% 34.46 mg/L 46.32 mg/L 0.743955094991364 +DTXSID4048195 Css 3compartmentss Human 95% 90.72 mg/L 110 mg/L 0.824727272727273 +DTXSID4048199 Css 3compartmentss Human 95% 0.613 mg/L 0.5994 mg/L 1.02268935602269 +DTXSID4048270 Css 3compartmentss Human 95% 9.888 mg/L 11.45 mg/L 0.863580786026201 +DTXSID4048276 Css 3compartmentss Human 95% 0.7446 mg/L NA NA NA +DTXSID4048436 Css 3compartmentss Human 95% 3.286 mg/L NA NA NA +DTXSID4048511 Css 3compartmentss Human 95% 1.478 mg/L 0.5124 mg/L 2.88446526151444 +DTXSID4048513 Css 3compartmentss Human 95% 11 mg/L 5.471 mg/L 2.01060135258636 +DTXSID4048519 Css 3compartmentss Human 95% 1.656 mg/L 2.011 mg/L 0.823470909995027 +DTXSID4048569 Css 3compartmentss Human 95% 1.887 mg/L NA NA NA +DTXSID4048640 Css 3compartmentss Human 95% 62.97 mg/L 1.647 mg/L 38.2331511839709 +DTXSID4048644 Css 3compartmentss Human 95% 2.156 mg/L 1.306 mg/L 1.65084226646248 +DTXSID4048646 Css 3compartmentss Human 95% 1.267 mg/L 4.916 mg/L 0.257729861676159 +DTXSID4048648 Css 3compartmentss Human 95% 8.176 mg/L 0.3744 mg/L 21.8376068376068 +DTXSID4048690 Css 3compartmentss Human 95% 10.91 mg/L 0.35 mg/L 31.1714285714286 +DTXSID4048692 Css 3compartmentss Human 95% 7.366 mg/L 4.302 mg/L 1.71222687122269 +DTXSID4048694 Css 3compartmentss Human 95% 1.082 mg/L 2.503 mg/L 0.432281262485018 +DTXSID4048696 Css 3compartmentss Human 95% 1.882 mg/L 8.1 mg/L 0.232345679012346 +DTXSID4048721 Css 3compartmentss Human 95% 1.015 mg/L 1.166 mg/L 0.870497427101201 +DTXSID4048723 Css 3compartmentss Human 95% 0.4409 mg/L NA NA NA +DTXSID4048725 Css 3compartmentss Human 95% 0.9796 mg/L 9.61 mg/L 0.101935483870968 +DTXSID4048727 Css 3compartmentss Human 95% 0.8318 mg/L 1.903 mg/L 0.437099316868103 +DTXSID4048729 Css 3compartmentss Human 95% 5.209 mg/L 5.669 mg/L 0.918856941259481 +DTXSID4048771 Css 3compartmentss Human 95% 10.75 mg/L 39.17 mg/L 0.274444728108246 +DTXSID4048773 Css 3compartmentss Human 95% 680.1 mg/L 261.8 mg/L 2.5977845683728 +DTXSID4048775 Css 3compartmentss Human 95% 0.4194 mg/L 0.9069 mg/L 0.462454515382071 +DTXSID4048777 Css 3compartmentss Human 95% 1.013 mg/L 1.567 mg/L 0.646458200382897 +DTXSID4048779 Css 3compartmentss Human 95% 6.74 mg/L 11.27 mg/L 0.598047914818101 +DTXSID4048800 Css 3compartmentss Human 95% 3.825 mg/L 2.263 mg/L 1.69023420238621 +DTXSID4048802 Css 3compartmentss Human 95% 0.8342 mg/L 0.6379 mg/L 1.30772848408842 +DTXSID4048804 Css 3compartmentss Human 95% 22.26 mg/L 26.56 mg/L 0.838102409638554 +DTXSID4048806 Css 3compartmentss Human 95% 0.7582 mg/L 0.1993 mg/L 3.80431510286001 +DTXSID4048808 Css 3compartmentss Human 95% 7.625 mg/L 1.029 mg/L 7.41010689990282 +DTXSID4048850 Css 3compartmentss Human 95% 0.7749 mg/L 2.283 mg/L 0.339421813403417 +DTXSID4048852 Css 3compartmentss Human 95% 2.343 mg/L 6.555 mg/L 0.357437070938215 +DTXSID4048854 Css 3compartmentss Human 95% 0.7283 mg/L 20.75 mg/L 0.0350987951807229 +DTXSID4048856 Css 3compartmentss Human 95% 1.283 mg/L 0.3289 mg/L 3.90088172696868 +DTXSID4048858 Css 3compartmentss Human 95% 0.9795 mg/L 0.459 mg/L 2.13398692810458 +DTXSID4048931 Css 3compartmentss Human 95% 5.591 mg/L 1.924 mg/L 2.90592515592516 +DTXSID4048933 Css 3compartmentss Human 95% 1.62 mg/L 4.859 mg/L 0.333401934554435 +DTXSID4048935 Css 3compartmentss Human 95% 3.459 mg/L 9.238 mg/L 0.374431695172115 +DTXSID4048937 Css 3compartmentss Human 95% 2.345 mg/L 7.293 mg/L 0.321541203894145 +DTXSID4048939 Css 3compartmentss Human 95% 0.9859 mg/L 0.5071 mg/L 1.94419246696904 +DTXSID4048981 Css 3compartmentss Human 95% 5.415 mg/L 9.628 mg/L 0.562422102201911 +DTXSID4048983 Css 3compartmentss Human 95% 2.33 mg/L 0.3243 mg/L 7.18470551958064 +DTXSID4048985 Css 3compartmentss Human 95% 15.47 mg/L 100.6 mg/L 0.153777335984095 +DTXSID4048987 Css 3compartmentss Human 95% 0.3856 mg/L 0.1854 mg/L 2.07982740021575 +DTXSID4049030 Css 3compartmentss Human 95% 6.596 mg/L 7.782 mg/L 0.847597018761244 +DTXSID4049032 Css 3compartmentss Human 95% 7.399 mg/L 27.45 mg/L 0.269544626593807 +DTXSID4049034 Css 3compartmentss Human 95% 4.295 mg/L 8.424 mg/L 0.509852801519468 +DTXSID4049036 Css 3compartmentss Human 95% 0.1882 mg/L 1.307 mg/L 0.143993879112471 +DTXSID4049038 Css 3compartmentss Human 95% 1.791 mg/L 2.094 mg/L 0.855300859598854 +DTXSID4049080 Css 3compartmentss Human 95% 1.016 mg/L 0.8599 mg/L 1.18153273636469 +DTXSID4049082 Css 3compartmentss Human 95% 14.44 mg/L 13.84 mg/L 1.04335260115607 +DTXSID4049240 Css 3compartmentss Human 95% 0.4869 mg/L 0.3122 mg/L 1.55957719410634 +DTXSID4049242 Css 3compartmentss Human 95% 7.772 mg/L 3.292 mg/L 2.36087484811665 +DTXSID4049327 Css 3compartmentss Human 95% 7.436 mg/L 21.83 mg/L 0.34063215758131 +DTXSID4049371 Css 3compartmentss Human 95% 0.6646 mg/L NA NA NA +DTXSID4049373 Css 3compartmentss Human 95% 1.348 mg/L 0.2635 mg/L 5.1157495256167 +DTXSID4049377 Css 3compartmentss Human 95% 7.385 mg/L 5.694 mg/L 1.29697927643133 +DTXSID4049379 Css 3compartmentss Human 95% 3.704 mg/L 11.74 mg/L 0.315502555366269 +DTXSID4049400 Css 3compartmentss Human 95% 12.62 mg/L 13.48 mg/L 0.93620178041543 +DTXSID4049404 Css 3compartmentss Human 95% 5.631 mg/L 6.436 mg/L 0.874922311995028 +DTXSID4049406 Css 3compartmentss Human 95% 1.807 mg/L 0.384 mg/L 4.70572916666667 +DTXSID4051536 Css 3compartmentss Human 95% 0.3195 mg/L 5.486 mg/L 0.0582391542107182 +DTXSID4051580 Css 3compartmentss Human 95% 6.386 mg/L 0.5835 mg/L 10.9443016281063 +DTXSID4051584 Css 3compartmentss Human 95% 1.541 mg/L NA NA NA +DTXSID4051619 Css 3compartmentss Human 95% 5.729 mg/L 6.851 mg/L 0.836228287841191 +DTXSID4051873 Css 3compartmentss Human 95% 9.154 mg/L NA NA NA +DTXSID4051900 Css 3compartmentss Human 95% 5.856 mg/L NA NA NA +DTXSID4051904 Css 3compartmentss Human 95% 1.855 mg/L NA NA NA +DTXSID4052134 Css 3compartmentss Human 95% 1.142 mg/L NA NA NA +DTXSID4052186 Css 3compartmentss Human 95% 3.38 mg/L 3.734 mg/L 0.905195500803428 +DTXSID4052213 Css 3compartmentss Human 95% 0.5973 mg/L 3.172 mg/L 0.188303909205549 +DTXSID4052267 Css 3compartmentss Human 95% 0.8294 mg/L 0.6282 mg/L 1.32028016555237 +DTXSID4052342 Css 3compartmentss Human 95% 5.608 mg/L 3.101 mg/L 1.80844888745566 +DTXSID4052502 Css 3compartmentss Human 95% 6.048 mg/L 142.6 mg/L 0.0424123422159888 +DTXSID4052506 Css 3compartmentss Human 95% 0.3087 mg/L 5.547 mg/L 0.0556517036235803 +DTXSID4052550 Css 3compartmentss Human 95% 0.7103 mg/L 3.869 mg/L 0.183587490307573 +DTXSID4052554 Css 3compartmentss Human 95% 7.023 mg/L 14.65 mg/L 0.47938566552901 +DTXSID4052635 Css 3compartmentss Human 95% 6.77 mg/L NA NA NA +DTXSID4052712 Css 3compartmentss Human 95% 7.9 mg/L NA NA NA +DTXSID4052714 Css 3compartmentss Human 95% 3.959 mg/L NA NA NA +DTXSID4052845 Css 3compartmentss Human 95% 0.5461 mg/L NA NA NA +DTXSID4057631 Css 3compartmentss Human 95% 2.248 mg/L 35.85 mg/L 0.0627057182705718 +DTXSID4057633 Css 3compartmentss Human 95% 3.241 mg/L 5.663 mg/L 0.572311495673671 +DTXSID4057635 Css 3compartmentss Human 95% 0.4127 mg/L 0.4195 mg/L 0.983790226460072 +DTXSID4057637 Css 3compartmentss Human 95% 0.368 mg/L 0.576 mg/L 0.638888888888889 +DTXSID4057639 Css 3compartmentss Human 95% 5.205 mg/L 0.1806 mg/L 28.8205980066445 +DTXSID4057681 Css 3compartmentss Human 95% 3.756 mg/L 0.9563 mg/L 3.92763777057409 +DTXSID4057683 Css 3compartmentss Human 95% 2.222 mg/L 2.425 mg/L 0.916288659793814 +DTXSID4057685 Css 3compartmentss Human 95% 32.2 mg/L 48.95 mg/L 0.657814096016343 +DTXSID4057687 Css 3compartmentss Human 95% 7.378 mg/L 5.663 mg/L 1.30284301606922 +DTXSID4057689 Css 3compartmentss Human 95% 21.79 mg/L 7.255 mg/L 3.00344589937974 +DTXSID4057710 Css 3compartmentss Human 95% 297.9 mg/L 352.8 mg/L 0.844387755102041 +DTXSID4057712 Css 3compartmentss Human 95% 4.114 mg/L 7.092 mg/L 0.580090242526791 +DTXSID4057714 Css 3compartmentss Human 95% 14.91 mg/L 12.52 mg/L 1.1908945686901 +DTXSID4057716 Css 3compartmentss Human 95% 10.32 mg/L 1.724 mg/L 5.9860788863109 +DTXSID4057718 Css 3compartmentss Human 95% 0.399 mg/L 1.712 mg/L 0.233060747663551 +DTXSID4057760 Css 3compartmentss Human 95% 0.656 mg/L 1.402 mg/L 0.467902995720399 +DTXSID4057762 Css 3compartmentss Human 95% 2.496 mg/L 19.01 mg/L 0.131299316149395 +DTXSID4057764 Css 3compartmentss Human 95% 1.022 mg/L 1.85 mg/L 0.552432432432432 +DTXSID4057768 Css 3compartmentss Human 95% 1.498 mg/L 1.005 mg/L 1.49054726368159 +DTXSID4057841 Css 3compartmentss Human 95% 1.078 mg/L 0.9116 mg/L 1.18253620008776 +DTXSID4057843 Css 3compartmentss Human 95% 0.7105 mg/L 1.967 mg/L 0.361209964412811 +DTXSID4057845 Css 3compartmentss Human 95% 1.474 mg/L 4.794 mg/L 0.307467667918231 +DTXSID4057847 Css 3compartmentss Human 95% 9.951 mg/L 40.38 mg/L 0.246433878157504 +DTXSID4057849 Css 3compartmentss Human 95% 18.44 mg/L 103 mg/L 0.179029126213592 +DTXSID4057899 Css 3compartmentss Human 95% 27.5 mg/L NA NA NA +DTXSID4058655 Css 3compartmentss Human 95% 19.36 mg/L 52.71 mg/L 0.367292733826598 +DTXSID4059702 Css 3compartmentss Human 95% 19.19 mg/L NA NA NA +DTXSID4060442 Css 3compartmentss Human 95% 7.165 mg/L NA NA NA +DTXSID4061098 Css 3compartmentss Human 95% 8.668 mg/L NA NA NA +DTXSID4063030 Css 3compartmentss Human 95% 19.97 mg/L NA NA NA +DTXSID40634520 Css 3compartmentss Human 95% 0.8956 mg/L NA NA NA +DTXSID40658943 Css 3compartmentss Human 95% 12.92 mg/L NA NA NA +DTXSID40678540 Css 3compartmentss Human 95% 6.766 mg/L NA NA NA +DTXSID40678984 Css 3compartmentss Human 95% 4.51 mg/L NA NA NA +DTXSID4073259 Css 3compartmentss Human 95% 0.4156 mg/L NA NA NA +DTXSID4075328 Css 3compartmentss Human 95% 0.7985 mg/L NA NA NA +DTXSID40861036 Css 3compartmentss Human 95% 10.7 mg/L NA NA NA +DTXSID40861672 Css 3compartmentss Human 95% 0.4244 mg/L NA NA NA +DTXSID40862245 Css 3compartmentss Human 95% 1.207 mg/L NA NA NA +DTXSID40862442 Css 3compartmentss Human 95% 2.645 mg/L NA NA NA +DTXSID40863297 Css 3compartmentss Human 95% 0.251 mg/L NA NA NA +DTXSID40863959 Css 3compartmentss Human 95% 0.286 mg/L NA NA NA +DTXSID40865110 Css 3compartmentss Human 95% 0.7779 mg/L NA NA NA +DTXSID40865478 Css 3compartmentss Human 95% 0.3538 mg/L NA NA NA +DTXSID40868303 Css 3compartmentss Human 95% 2.389 mg/L NA NA NA +DTXSID40868904 Css 3compartmentss Human 95% 0.2587 mg/L NA NA NA +DTXSID40869032 Css 3compartmentss Human 95% 3.146 mg/L NA NA NA +DTXSID40869118 Css 3compartmentss Human 95% 6.541 mg/L NA NA NA +DTXSID40869931 Css 3compartmentss Human 95% 8.809 mg/L NA NA NA +DTXSID40869971 Css 3compartmentss Human 95% 15.77 mg/L NA NA NA +DTXSID40870229 Css 3compartmentss Human 95% 4.553 mg/L NA NA NA +DTXSID40873215 Css 3compartmentss Human 95% 3.839 mg/L NA NA NA +DTXSID40874368 Css 3compartmentss Human 95% 11.39 mg/L NA NA NA +DTXSID40880060 Css 3compartmentss Human 95% 2.368 mg/L NA NA NA +DTXSID40880686 Css 3compartmentss Human 95% 20.18 mg/L NA NA NA +DTXSID40880707 Css 3compartmentss Human 95% 9.336 mg/L NA NA NA +DTXSID40880722 Css 3compartmentss Human 95% 1.769 mg/L NA NA NA +DTXSID40880762 Css 3compartmentss Human 95% 0.2355 mg/L NA NA NA +DTXSID40880808 Css 3compartmentss Human 95% 19.17 mg/L NA NA NA +DTXSID40880868 Css 3compartmentss Human 95% 16.01 mg/L NA NA NA +DTXSID40880888 Css 3compartmentss Human 95% 0.9645 mg/L NA NA NA +DTXSID40880904 Css 3compartmentss Human 95% 9.715 mg/L NA NA NA +DTXSID40880909 Css 3compartmentss Human 95% 1.618 mg/L NA NA NA +DTXSID40880924 Css 3compartmentss Human 95% 5.247 mg/L NA NA NA +DTXSID40880929 Css 3compartmentss Human 95% 0.6903 mg/L NA NA NA +DTXSID40881214 Css 3compartmentss Human 95% 1.268 mg/L NA NA NA +DTXSID40893458 Css 3compartmentss Human 95% 8.626 mg/L NA NA NA +DTXSID40909301 Css 3compartmentss Human 95% 2.138 mg/L NA NA NA +DTXSID40938196 Css 3compartmentss Human 95% 1.31 mg/L NA NA NA +DTXSID40961762 Css 3compartmentss Human 95% 8.163 mg/L NA NA NA +DTXSID501018140 Css 3compartmentss Human 95% 7.035 mg/L 8.943 mg/L 0.786648775578665 +DTXSID50110042 Css 3compartmentss Human 95% 13.36 mg/L NA NA NA +DTXSID501104846 Css 3compartmentss Human 95% 2.366 mg/L NA NA NA +DTXSID501123076 Css 3compartmentss Human 95% 0.9163 mg/L NA NA NA +DTXSID501123595 Css 3compartmentss Human 95% 1.151 mg/L NA NA NA +DTXSID50143299 Css 3compartmentss Human 95% 7.264 mg/L NA NA NA +DTXSID50146982 Css 3compartmentss Human 95% 1.319 mg/L NA NA NA +DTXSID50147939 Css 3compartmentss Human 95% 8.307 mg/L NA NA NA +DTXSID50148507 Css 3compartmentss Human 95% 0.4438 mg/L NA NA NA +DTXSID50149493 Css 3compartmentss Human 95% 48.61 mg/L NA NA NA +DTXSID50152604 Css 3compartmentss Human 95% 14.19 mg/L NA NA NA +DTXSID50154840 Css 3compartmentss Human 95% 27.31 mg/L NA NA NA +DTXSID50163295 Css 3compartmentss Human 95% 8.1 mg/L NA NA NA +DTXSID50165456 Css 3compartmentss Human 95% 3.945 mg/L NA NA NA +DTXSID50165552 Css 3compartmentss Human 95% 0.8865 mg/L NA NA NA +DTXSID50165895 Css 3compartmentss Human 95% 3.964 mg/L NA NA NA +DTXSID50166423 Css 3compartmentss Human 95% 8.164 mg/L NA NA NA +DTXSID50168008 Css 3compartmentss Human 95% 272.2 mg/L NA NA NA +DTXSID50171375 Css 3compartmentss Human 95% 10.55 mg/L NA NA NA +DTXSID50171996 Css 3compartmentss Human 95% 2.992 mg/L NA NA NA +DTXSID50175232 Css 3compartmentss Human 95% 1.509 mg/L NA NA NA +DTXSID50175419 Css 3compartmentss Human 95% 1.932 mg/L NA NA NA +DTXSID50175656 Css 3compartmentss Human 95% 6.077 mg/L NA NA NA +DTXSID50176365 Css 3compartmentss Human 95% 9.422 mg/L NA NA NA +DTXSID50183271 Css 3compartmentss Human 95% 19.5 mg/L NA NA NA +DTXSID50183615 Css 3compartmentss Human 95% 0.7163 mg/L NA NA NA +DTXSID50187178 Css 3compartmentss Human 95% 20.15 mg/L NA NA NA +DTXSID50188024 Css 3compartmentss Human 95% 12.1 mg/L NA NA NA +DTXSID50189319 Css 3compartmentss Human 95% 0.926 mg/L NA NA NA +DTXSID50196583 Css 3compartmentss Human 95% 20.75 mg/L NA NA NA +DTXSID50197398 Css 3compartmentss Human 95% 0.4173 mg/L NA NA NA +DTXSID50198249 Css 3compartmentss Human 95% 2.344 mg/L NA NA NA +DTXSID5020021 Css 3compartmentss Human 95% 15.65 mg/L 18.4 mg/L 0.85054347826087 +DTXSID5020027 Css 3compartmentss Human 95% 2.869 mg/L 3.563 mg/L 0.805220319955094 +DTXSID50200412 Css 3compartmentss Human 95% 8.674 mg/L NA NA NA +DTXSID5020071 Css 3compartmentss Human 95% 2.641 mg/L 4.993 mg/L 0.528940516723413 +DTXSID5020079 Css 3compartmentss Human 95% 5.166 mg/L 5.842 mg/L 0.884286203355016 +DTXSID5020106 Css 3compartmentss Human 95% 0.3599 mg/L 10.38 mg/L 0.0346724470134875 +DTXSID5020108 Css 3compartmentss Human 95% 0.4716 mg/L 0.5535 mg/L 0.852032520325203 +DTXSID5020152 Css 3compartmentss Human 95% 0.3679 mg/L 1.98 mg/L 0.185808080808081 +DTXSID5020156 Css 3compartmentss Human 95% 0.9311 mg/L 2.257 mg/L 0.412538768276473 +DTXSID5020231 Css 3compartmentss Human 95% 5.111 mg/L 17.39 mg/L 0.293904542840713 +DTXSID5020233 Css 3compartmentss Human 95% 0.002836 mg/L 0.09173 mg/L 0.0309168211054181 +DTXSID5020239 Css 3compartmentss Human 95% 10.4 mg/L 16.23 mg/L 0.640788662969809 +DTXSID5020281 Css 3compartmentss Human 95% 0.04776 mg/L 0.05458 mg/L 0.875045804323928 +DTXSID5020283 Css 3compartmentss Human 95% 0.2308 mg/L 0.2353 mg/L 0.980875478113047 +DTXSID5020287 Css 3compartmentss Human 95% 2.927 mg/L 2.526 mg/L 1.15874901029295 +DTXSID5020310 Css 3compartmentss Human 95% 23.45 mg/L NA NA NA +DTXSID5020312 Css 3compartmentss Human 95% 14.53 mg/L 5.589 mg/L 2.59974950796207 +DTXSID5020360 Css 3compartmentss Human 95% 1.661 mg/L 3.417 mg/L 0.486098917178812 +DTXSID5020364 Css 3compartmentss Human 95% 3.296 mg/L NA NA NA +DTXSID5020366 Css 3compartmentss Human 95% 14.09 mg/L 13.1 mg/L 1.07557251908397 +DTXSID5020368 Css 3compartmentss Human 95% 6.944 mg/L 11.13 mg/L 0.623899371069182 +DTXSID5020441 Css 3compartmentss Human 95% 6.932 mg/L 54.13 mg/L 0.128062072787733 +DTXSID5020443 Css 3compartmentss Human 95% 12.13 mg/L 2.936 mg/L 4.13147138964578 +DTXSID5020445 Css 3compartmentss Human 95% 9.995 mg/L 2.149 mg/L 4.65100046533271 +DTXSID5020447 Css 3compartmentss Human 95% 26.86 mg/L NA NA NA +DTXSID5020449 Css 3compartmentss Human 95% 16.84 mg/L 16.56 mg/L 1.01690821256039 +DTXSID5020491 Css 3compartmentss Human 95% 13.55 mg/L 9.18 mg/L 1.4760348583878 +DTXSID5020493 Css 3compartmentss Human 95% 5.257 mg/L 6.077 mg/L 0.865064999177226 +DTXSID5020497 Css 3compartmentss Human 95% 6.44 mg/L 1.466 mg/L 4.39290586630287 +DTXSID5020499 Css 3compartmentss Human 95% 4.366 mg/L 4.912 mg/L 0.888843648208469 +DTXSID5020528 Css 3compartmentss Human 95% 1.119 mg/L 1.124 mg/L 0.995551601423487 +DTXSID5020570 Css 3compartmentss Human 95% 5.414 mg/L 6.477 mg/L 0.83588080901652 +DTXSID5020572 Css 3compartmentss Human 95% 14.22 mg/L 8.444 mg/L 1.68403600189484 +DTXSID5020576 Css 3compartmentss Human 95% 418 mg/L 414 mg/L 1.00966183574879 +DTXSID5020601 Css 3compartmentss Human 95% 3.41 mg/L 4.218 mg/L 0.808440018966335 +DTXSID5020603 Css 3compartmentss Human 95% 6.468 mg/L 2.105 mg/L 3.07268408551069 +DTXSID5020605 Css 3compartmentss Human 95% 1.259 mg/L 2.603 mg/L 0.483672685363043 +DTXSID5020607 Css 3compartmentss Human 95% 2128 mg/L 2218 mg/L 0.959422903516682 +DTXSID5020653 Css 3compartmentss Human 95% 50.28 mg/L 7.221 mg/L 6.96302451184047 +DTXSID5020659 Css 3compartmentss Human 95% 5.012 mg/L 5.933 mg/L 0.844766559919097 +DTXSID50207128 Css 3compartmentss Human 95% 0.6799 mg/L NA NA NA +DTXSID5020730 Css 3compartmentss Human 95% 0.635 mg/L 0.6378 mg/L 0.995609909062402 +DTXSID5020732 Css 3compartmentss Human 95% 64.31 mg/L 53.63 mg/L 1.19914227111691 +DTXSID5020738 Css 3compartmentss Human 95% 0.5655 mg/L 28.72 mg/L 0.0196901114206128 +DTXSID5020782 Css 3compartmentss Human 95% 10.58 mg/L 604.9 mg/L 0.0174904942965779 +DTXSID5020784 Css 3compartmentss Human 95% 468.5 mg/L 486.4 mg/L 0.963199013157895 +DTXSID5020815 Css 3compartmentss Human 95% 7.361 mg/L NA NA NA +DTXSID50208175 Css 3compartmentss Human 95% 2.478 mg/L NA NA NA +DTXSID5020819 Css 3compartmentss Human 95% 2.424 mg/L 2.436 mg/L 0.995073891625616 +DTXSID5020861 Css 3compartmentss Human 95% 0.3604 mg/L 0.5633 mg/L 0.639801171666962 +DTXSID5020863 Css 3compartmentss Human 95% 4.183 mg/L 5.576 mg/L 0.750179340028694 +DTXSID5020865 Css 3compartmentss Human 95% 14.13 mg/L 1.139 mg/L 12.4056189640035 +DTXSID5020867 Css 3compartmentss Human 95% 2.795 mg/L 2.756 mg/L 1.01415094339623 +DTXSID5020869 Css 3compartmentss Human 95% 206.7 mg/L 187.4 mg/L 1.10298826040555 +DTXSID5020944 Css 3compartmentss Human 95% 2.636 mg/L 2.721 mg/L 0.968761484748254 +DTXSID5020946 Css 3compartmentss Human 95% 0.4089 mg/L 0.9766 mg/L 0.418697522015155 +DTXSID5020948 Css 3compartmentss Human 95% 0.6209 mg/L 13.23 mg/L 0.0469312169312169 +DTXSID5021093 Css 3compartmentss Human 95% 0.7652 mg/L 0.2614 mg/L 2.92731446059679 +DTXSID5021097 Css 3compartmentss Human 95% 6.87 mg/L 8.196 mg/L 0.838213762811127 +DTXSID5021120 Css 3compartmentss Human 95% 3.835 mg/L NA NA NA +DTXSID5021122 Css 3compartmentss Human 95% 5.553 mg/L 7.339 mg/L 0.756642594358904 +DTXSID5021124 Css 3compartmentss Human 95% 0.9436 mg/L 1.038 mg/L 0.909055876685934 +DTXSID5021126 Css 3compartmentss Human 95% 709.9 mg/L 737.4 mg/L 0.962706807702739 +DTXSID5021128 Css 3compartmentss Human 95% 0.7107 mg/L NA NA NA +DTXSID5021170 Css 3compartmentss Human 95% 8.107 mg/L 71.19 mg/L 0.113878353701363 +DTXSID5021201 Css 3compartmentss Human 95% 2.421 mg/L 2.327 mg/L 1.04039535883111 +DTXSID5021209 Css 3compartmentss Human 95% 2.708 mg/L 2.767 mg/L 0.978677267799061 +DTXSID5021251 Css 3compartmentss Human 95% 3.211 mg/L 3.382 mg/L 0.949438202247191 +DTXSID5021253 Css 3compartmentss Human 95% 7.592 mg/L 10.61 mg/L 0.71555136663525 +DTXSID5021255 Css 3compartmentss Human 95% 3.655 mg/L 4.404 mg/L 0.829927338782925 +DTXSID5021330 Css 3compartmentss Human 95% 3.057 mg/L 3.217 mg/L 0.950264221324215 +DTXSID5021332 Css 3compartmentss Human 95% 21.55 mg/L 20.92 mg/L 1.03011472275335 +DTXSID5021334 Css 3compartmentss Human 95% 6.532 mg/L 7.29 mg/L 0.8960219478738 +DTXSID5021336 Css 3compartmentss Human 95% 1.734 mg/L 3.212 mg/L 0.539850560398506 +DTXSID5021338 Css 3compartmentss Human 95% 5.296 mg/L 2.407 mg/L 2.20024927295388 +DTXSID5021386 Css 3compartmentss Human 95% 18.1 mg/L 18.28 mg/L 0.990153172866521 +DTXSID5021388 Css 3compartmentss Human 95% 183.3 mg/L 194.8 mg/L 0.940965092402464 +DTXSID5021411 Css 3compartmentss Human 95% 1.284 mg/L 1.323 mg/L 0.970521541950113 +DTXSID5021413 Css 3compartmentss Human 95% 2.238 mg/L NA NA NA +DTXSID5021415 Css 3compartmentss Human 95% 6.004 mg/L 1.476 mg/L 4.06775067750677 +DTXSID5021419 Css 3compartmentss Human 95% 8.991 mg/L 4.772 mg/L 1.88411567476949 +DTXSID5021461 Css 3compartmentss Human 95% 8.59 mg/L 9.805 mg/L 0.876083630800612 +DTXSID5021463 Css 3compartmentss Human 95% 7.872 mg/L 2.559 mg/L 3.07620164126612 +DTXSID50214655 Css 3compartmentss Human 95% 17.43 mg/L NA NA NA +DTXSID5021544 Css 3compartmentss Human 95% 0.7365 mg/L 1.107 mg/L 0.665311653116531 +DTXSID5021546 Css 3compartmentss Human 95% 6.612 mg/L 7.41 mg/L 0.892307692307692 +DTXSID5021590 Css 3compartmentss Human 95% 9.019 mg/L 37.9 mg/L 0.237968337730871 +DTXSID5021598 Css 3compartmentss Human 95% 3.677 mg/L 3.674 mg/L 1.00081654872074 +DTXSID5021621 Css 3compartmentss Human 95% 6.327 mg/L 7.979 mg/L 0.792956510840958 +DTXSID5021627 Css 3compartmentss Human 95% 6.33 mg/L 9.784 mg/L 0.646974652493868 +DTXSID5021671 Css 3compartmentss Human 95% 7.614 mg/L 8.178 mg/L 0.931034482758621 +DTXSID5021679 Css 3compartmentss Human 95% 7.534 mg/L 8.196 mg/L 0.919228892142509 +DTXSID5021708 Css 3compartmentss Human 95% 0.4011 mg/L 24.16 mg/L 0.016601821192053 +DTXSID5021754 Css 3compartmentss Human 95% 4.934 mg/L 5.687 mg/L 0.867592755407069 +DTXSID5021756 Css 3compartmentss Human 95% 0.3212 mg/L 5.503 mg/L 0.0583681628202798 +DTXSID5021758 Css 3compartmentss Human 95% 3.883 mg/L 0.2979 mg/L 13.0345753608593 +DTXSID5021831 Css 3compartmentss Human 95% 3.538 mg/L 3.749 mg/L 0.943718324886636 +DTXSID5021835 Css 3compartmentss Human 95% 0.4289 mg/L 0.3667 mg/L 1.16962094355059 +DTXSID5021837 Css 3compartmentss Human 95% 5.807 mg/L 4.33 mg/L 1.34110854503464 +DTXSID5021839 Css 3compartmentss Human 95% 0.295 mg/L 1.547 mg/L 0.190691661279897 +DTXSID5021881 Css 3compartmentss Human 95% 4.88 mg/L 5.503 mg/L 0.886789024168635 +DTXSID5021883 Css 3compartmentss Human 95% 5.798 mg/L 6.7 mg/L 0.865373134328358 +DTXSID5021885 Css 3compartmentss Human 95% 0.2544 mg/L 5.286 mg/L 0.0481271282633371 +DTXSID5021910 Css 3compartmentss Human 95% 2.271 mg/L 2.86 mg/L 0.794055944055944 +DTXSID5021962 Css 3compartmentss Human 95% 7.391 mg/L 1.239 mg/L 5.96529459241324 +DTXSID5021968 Css 3compartmentss Human 95% 0.5168 mg/L 0.6321 mg/L 0.817592153140326 +DTXSID5022061 Css 3compartmentss Human 95% 0.7878 mg/L 2.446 mg/L 0.322076860179885 +DTXSID5022140 Css 3compartmentss Human 95% 2.374 mg/L NA NA NA +DTXSID5022146 Css 3compartmentss Human 95% 1.496 mg/L NA NA NA +DTXSID5022198 Css 3compartmentss Human 95% 0.3717 mg/L 1.334 mg/L 0.27863568215892 +DTXSID5022271 Css 3compartmentss Human 95% 1.235 mg/L 2.147 mg/L 0.575221238938053 +DTXSID5022279 Css 3compartmentss Human 95% 3.62 mg/L 6.97 mg/L 0.519368723098996 +DTXSID5022308 Css 3compartmentss Human 95% 11.39 mg/L 12.25 mg/L 0.929795918367347 +DTXSID5022437 Css 3compartmentss Human 95% 1.775 mg/L 3.01 mg/L 0.589700996677741 +DTXSID5022439 Css 3compartmentss Human 95% 54.47 mg/L 86.13 mg/L 0.632416115174736 +DTXSID5022481 Css 3compartmentss Human 95% 0.05008 mg/L 0.008282 mg/L 6.04684858729775 +DTXSID5022485 Css 3compartmentss Human 95% 27.41 mg/L 510.3 mg/L 0.05371350186165 +DTXSID5022489 Css 3compartmentss Human 95% 3.663 mg/L 31.77 mg/L 0.115297450424929 +DTXSID5022510 Css 3compartmentss Human 95% 2.21 mg/L 2.717 mg/L 0.813397129186603 +DTXSID5022514 Css 3compartmentss Human 95% 8179 mg/L NA NA NA +DTXSID5022560 Css 3compartmentss Human 95% 6.941 mg/L 7.758 mg/L 0.894689352926012 +DTXSID5022562 Css 3compartmentss Human 95% 2.931 mg/L 2.395 mg/L 1.22379958246347 +DTXSID5022641 Css 3compartmentss Human 95% 0.7568 mg/L 2.728 mg/L 0.27741935483871 +DTXSID5022643 Css 3compartmentss Human 95% 6.238 mg/L 7.039 mg/L 0.886205426907231 +DTXSID5022647 Css 3compartmentss Human 95% 3.636 mg/L 1.548 mg/L 2.34883720930233 +DTXSID5022649 Css 3compartmentss Human 95% 8.299 mg/L 3.029 mg/L 2.73984813469792 +DTXSID5022697 Css 3compartmentss Human 95% 0.6785 mg/L NA NA NA +DTXSID5022699 Css 3compartmentss Human 95% 24.61 mg/L 5.711 mg/L 4.30922780598844 +DTXSID5022722 Css 3compartmentss Human 95% 25.72 mg/L 1.509 mg/L 17.0444002650762 +DTXSID5022724 Css 3compartmentss Human 95% 1.761 mg/L 10.71 mg/L 0.164425770308123 +DTXSID5022770 Css 3compartmentss Human 95% 3.439 mg/L NA NA NA +DTXSID50227700 Css 3compartmentss Human 95% 2.318 mg/L NA NA NA +DTXSID5022772 Css 3compartmentss Human 95% 4.068 mg/L NA NA NA +DTXSID5022774 Css 3compartmentss Human 95% 4.364 mg/L 9.089 mg/L 0.480140829574211 +DTXSID50227886 Css 3compartmentss Human 95% 0.971 mg/L NA NA NA +DTXSID5022801 Css 3compartmentss Human 95% 15.3 mg/L 31.15 mg/L 0.491171749598716 +DTXSID5022803 Css 3compartmentss Human 95% 0.3857 mg/L 0.1749 mg/L 2.20526014865638 +DTXSID5022851 Css 3compartmentss Human 95% 2.75 mg/L 11.04 mg/L 0.249094202898551 +DTXSID5022855 Css 3compartmentss Human 95% 6.015 mg/L 5.755 mg/L 1.04517810599479 +DTXSID5022857 Css 3compartmentss Human 95% 0.5281 mg/L 0.8026 mg/L 0.657986543732868 +DTXSID5022932 Css 3compartmentss Human 95% 941.4 mg/L 882.5 mg/L 1.06674220963173 +DTXSID5022934 Css 3compartmentss Human 95% 4.445 mg/L 6.856 mg/L 0.648337222870478 +DTXSID5022938 Css 3compartmentss Human 95% 2.091 mg/L 0.0856 mg/L 24.4275700934579 +DTXSID5022980 Css 3compartmentss Human 95% 0.5897 mg/L 0.8034 mg/L 0.734005476723923 +DTXSID5022982 Css 3compartmentss Human 95% 0.6596 mg/L 11.38 mg/L 0.0579613356766257 +DTXSID5022984 Css 3compartmentss Human 95% 0.4229 mg/L 0.7973 mg/L 0.530415151135081 +DTXSID5022986 Css 3compartmentss Human 95% 4.668 mg/L 1.236 mg/L 3.77669902912621 +DTXSID5023031 Css 3compartmentss Human 95% 6.677 mg/L 1.724 mg/L 3.87296983758701 +DTXSID5023033 Css 3compartmentss Human 95% 1.263 mg/L 1.31 mg/L 0.96412213740458 +DTXSID5023035 Css 3compartmentss Human 95% 35.62 mg/L 1.533 mg/L 23.235485975212 +DTXSID5023037 Css 3compartmentss Human 95% 9.404 mg/L NA NA NA +DTXSID5023039 Css 3compartmentss Human 95% 2.872 mg/L 2.88 mg/L 0.997222222222222 +DTXSID5023081 Css 3compartmentss Human 95% 5.209 mg/L 5.667 mg/L 0.919181224633845 +DTXSID5023085 Css 3compartmentss Human 95% 0.5252 mg/L 39.93 mg/L 0.013153017781117 +DTXSID5023089 Css 3compartmentss Human 95% 2.133 mg/L 935.5 mg/L 0.00228006413682523 +DTXSID5023110 Css 3compartmentss Human 95% 21.43 mg/L 0.7256 mg/L 29.5341786108049 +DTXSID5023114 Css 3compartmentss Human 95% 7.669 mg/L 0.01194 mg/L 642.294807370184 +DTXSID5023166 Css 3compartmentss Human 95% 37.05 mg/L 41.52 mg/L 0.892341040462428 +DTXSID5023243 Css 3compartmentss Human 95% 20.58 mg/L 27.7 mg/L 0.742960288808664 +DTXSID5023247 Css 3compartmentss Human 95% 3.1 mg/L 12.35 mg/L 0.251012145748988 +DTXSID5023293 Css 3compartmentss Human 95% 1.577 mg/L 0.08952 mg/L 17.6161751563896 +DTXSID5023295 Css 3compartmentss Human 95% 3.269 mg/L 5.798 mg/L 0.563815108658158 +DTXSID5023299 Css 3compartmentss Human 95% 1.255 mg/L 1.268 mg/L 0.989747634069401 +DTXSID5023320 Css 3compartmentss Human 95% 7.029 mg/L 5.649 mg/L 1.24429102496017 +DTXSID5023322 Css 3compartmentss Human 95% 9.407 mg/L 8.976 mg/L 1.04801693404635 +DTXSID5023324 Css 3compartmentss Human 95% 19.95 mg/L 82.15 mg/L 0.242848447961047 +DTXSID5023370 Css 3compartmentss Human 95% 17.11 mg/L 1.605 mg/L 10.6604361370717 +DTXSID5023372 Css 3compartmentss Human 95% 2.919 mg/L 4.946 mg/L 0.590173877881116 +DTXSID5023376 Css 3compartmentss Human 95% 3.122 mg/L 0.1762 mg/L 17.7185017026107 +DTXSID5023378 Css 3compartmentss Human 95% 5.004 mg/L 1.8 mg/L 2.78 +DTXSID5023407 Css 3compartmentss Human 95% 4.977 mg/L NA NA NA +DTXSID5023453 Css 3compartmentss Human 95% 6.641 mg/L 218.3 mg/L 0.0304214383875401 +DTXSID5023459 Css 3compartmentss Human 95% 2.659 mg/L NA NA NA +DTXSID5023532 Css 3compartmentss Human 95% 34.55 mg/L 0.5953 mg/L 58.0379640517386 +DTXSID5023536 Css 3compartmentss Human 95% 5.661 mg/L 1.802 mg/L 3.14150943396226 +DTXSID5023582 Css 3compartmentss Human 95% 5.765 mg/L 3.221 mg/L 1.78981682707234 +DTXSID5023584 Css 3compartmentss Human 95% 0.08807 mg/L 0.01495 mg/L 5.89096989966555 +DTXSID5023586 Css 3compartmentss Human 95% 13.74 mg/L 0.9832 mg/L 13.9747762408462 +DTXSID5023588 Css 3compartmentss Human 95% 5.093 mg/L 5.588 mg/L 0.911417322834646 +DTXSID5023611 Css 3compartmentss Human 95% 2.015 mg/L 5.191 mg/L 0.388171835869775 +DTXSID5023613 Css 3compartmentss Human 95% 2.236 mg/L 5.317 mg/L 0.420537897310513 +DTXSID5023615 Css 3compartmentss Human 95% 3.102 mg/L 9.836 mg/L 0.315372102480683 +DTXSID5023661 Css 3compartmentss Human 95% 2.849 mg/L 5.332 mg/L 0.534321080270068 +DTXSID5023663 Css 3compartmentss Human 95% 7.182 mg/L NA NA NA +DTXSID5023665 Css 3compartmentss Human 95% 21.52 mg/L 242.8 mg/L 0.0886326194398682 +DTXSID5023667 Css 3compartmentss Human 95% 3.076 mg/L 1.848 mg/L 1.66450216450216 +DTXSID5023740 Css 3compartmentss Human 95% 397.7 mg/L 997.8 mg/L 0.398576869112046 +DTXSID5023742 Css 3compartmentss Human 95% 326.9 mg/L 291.7 mg/L 1.12067192320878 +DTXSID5023744 Css 3compartmentss Human 95% 10.06 mg/L 6.446 mg/L 1.56065777226187 +DTXSID5023746 Css 3compartmentss Human 95% 17.75 mg/L 13.91 mg/L 1.27606038820992 +DTXSID5023748 Css 3compartmentss Human 95% 1.291 mg/L 1.624 mg/L 0.794950738916256 +DTXSID5023792 Css 3compartmentss Human 95% 0.7334 mg/L 0.7784 mg/L 0.942189105858171 +DTXSID5023794 Css 3compartmentss Human 95% 2.359 mg/L 17.82 mg/L 0.132379349046016 +DTXSID5023796 Css 3compartmentss Human 95% 5.36 mg/L 1.207 mg/L 4.44076222038111 +DTXSID5023871 Css 3compartmentss Human 95% 33.79 mg/L 31.92 mg/L 1.05858395989975 +DTXSID50238710 Css 3compartmentss Human 95% 8.557 mg/L NA NA NA +DTXSID5023877 Css 3compartmentss Human 95% 7.383 mg/L 7.631 mg/L 0.96750098283318 +DTXSID5023902 Css 3compartmentss Human 95% 25.95 mg/L 29.28 mg/L 0.886270491803279 +DTXSID5023950 Css 3compartmentss Human 95% 15.85 mg/L 16.02 mg/L 0.989388264669164 +DTXSID5024001 Css 3compartmentss Human 95% 7.303 mg/L 8.362 mg/L 0.873355656541497 +DTXSID5024055 Css 3compartmentss Human 95% 4.47 mg/L 5.376 mg/L 0.831473214285714 +DTXSID5024057 Css 3compartmentss Human 95% 6.198 mg/L 6.893 mg/L 0.899173074133179 +DTXSID5024059 Css 3compartmentss Human 95% 29.74 mg/L 31.39 mg/L 0.947435489009239 +DTXSID5024134 Css 3compartmentss Human 95% 102.2 mg/L 114.7 mg/L 0.891020052310375 +DTXSID50241486 Css 3compartmentss Human 95% 5.667 mg/L NA NA NA +DTXSID50241749 Css 3compartmentss Human 95% 17.57 mg/L NA NA NA +DTXSID5024182 Css 3compartmentss Human 95% 5.112 mg/L 5.689 mg/L 0.8985761996836 +DTXSID5024211 Css 3compartmentss Human 95% 4.777 mg/L 6.498 mg/L 0.735149276700523 +DTXSID5024261 Css 3compartmentss Human 95% 4.796 mg/L 4.839 mg/L 0.991113866501343 +DTXSID5024344 Css 3compartmentss Human 95% 1200 mg/L NA NA NA +DTXSID5024392 Css 3compartmentss Human 95% 0.5652 mg/L 11.62 mg/L 0.0486402753872633 +DTXSID5024394 Css 3compartmentss Human 95% 8.544 mg/L 9.805 mg/L 0.871392146863845 +DTXSID5024471 Css 3compartmentss Human 95% 2.138 mg/L 0.3708 mg/L 5.76591154261057 +DTXSID5024473 Css 3compartmentss Human 95% 0.5344 mg/L 0.4695 mg/L 1.13823216187433 +DTXSID5024479 Css 3compartmentss Human 95% 28.09 mg/L 12.83 mg/L 2.18939984411535 +DTXSID5024500 Css 3compartmentss Human 95% 5.187 mg/L 9.214 mg/L 0.562947688300412 +DTXSID5024504 Css 3compartmentss Human 95% 7.445 mg/L 7.072 mg/L 1.05274321266968 +DTXSID5024506 Css 3compartmentss Human 95% 5.214 mg/L 8.154 mg/L 0.63944076526858 +DTXSID5024508 Css 3compartmentss Human 95% 0.6104 mg/L 0.7091 mg/L 0.86080947680158 +DTXSID5024554 Css 3compartmentss Human 95% 3.743 mg/L 0.385 mg/L 9.72207792207792 +DTXSID5024681 Css 3compartmentss Human 95% 0.4423 mg/L 0.5503 mg/L 0.803743412683991 +DTXSID5024683 Css 3compartmentss Human 95% 3.679 mg/L 1.446 mg/L 2.54426002766252 +DTXSID5024687 Css 3compartmentss Human 95% 2.106 mg/L 5.291 mg/L 0.398034398034398 +DTXSID5024710 Css 3compartmentss Human 95% 4.73 mg/L 5.592 mg/L 0.84585121602289 +DTXSID5024764 Css 3compartmentss Human 95% 1.423 mg/L 1.168 mg/L 1.21832191780822 +DTXSID5024845 Css 3compartmentss Human 95% 3.476 mg/L 3.8 mg/L 0.914736842105263 +DTXSID5024891 Css 3compartmentss Human 95% 0.08899 mg/L 0.1666 mg/L 0.534153661464586 +DTXSID5024922 Css 3compartmentss Human 95% 0.4005 mg/L 0.4836 mg/L 0.828163771712159 +DTXSID5024926 Css 3compartmentss Human 95% 2.454 mg/L 12.92 mg/L 0.189938080495356 +DTXSID5024970 Css 3compartmentss Human 95% 2.573 mg/L NA NA NA +DTXSID5024976 Css 3compartmentss Human 95% 3.028 mg/L 113.3 mg/L 0.0267255075022065 +DTXSID5024978 Css 3compartmentss Human 95% 3.045 mg/L 104 mg/L 0.0292788461538462 +DTXSID5025021 Css 3compartmentss Human 95% 20.3 mg/L 7.376 mg/L 2.75216919739696 +DTXSID5025079 Css 3compartmentss Human 95% 0.2434 mg/L NA NA NA +DTXSID5025100 Css 3compartmentss Human 95% 5.003 mg/L 2.636 mg/L 1.89795144157815 +DTXSID5025102 Css 3compartmentss Human 95% 2.133 mg/L 2.471 mg/L 0.863213273978147 +DTXSID5025150 Css 3compartmentss Human 95% 7.333 mg/L 8.248 mg/L 0.889064015518914 +DTXSID5025152 Css 3compartmentss Human 95% 0.01616 mg/L 0.01975 mg/L 0.818227848101266 +DTXSID5025156 Css 3compartmentss Human 95% 6.612 mg/L 5.589 mg/L 1.18303811057434 +DTXSID5025231 Css 3compartmentss Human 95% 5.228 mg/L 58.39 mg/L 0.0895358794314095 +DTXSID5025237 Css 3compartmentss Human 95% 4.615 mg/L 5.067 mg/L 0.910795342411683 +DTXSID5025310 Css 3compartmentss Human 95% 1.343 mg/L 2.61 mg/L 0.51455938697318 +DTXSID5025312 Css 3compartmentss Human 95% 5.647 mg/L 5.202 mg/L 1.08554402153018 +DTXSID5025364 Css 3compartmentss Human 95% 7.071 mg/L 8.023 mg/L 0.881341144210395 +DTXSID5025449 Css 3compartmentss Human 95% 3.13 mg/L 4.907 mg/L 0.637864275524761 +DTXSID5025491 Css 3compartmentss Human 95% 3.127 mg/L 84.4 mg/L 0.0370497630331754 +DTXSID5025493 Css 3compartmentss Human 95% 5.058 mg/L NA NA NA +DTXSID5025570 Css 3compartmentss Human 95% 0.3717 mg/L 0.3329 mg/L 1.11655151697206 +DTXSID5025574 Css 3compartmentss Human 95% 0.4259 mg/L 0.9992 mg/L 0.426240992794235 +DTXSID5025603 Css 3compartmentss Human 95% 2.968 mg/L 3.585 mg/L 0.8278940027894 +DTXSID5025607 Css 3compartmentss Human 95% 1.327 mg/L NA NA NA +DTXSID5025653 Css 3compartmentss Human 95% 0.8884 mg/L 1.526 mg/L 0.582175622542595 +DTXSID5025659 Css 3compartmentss Human 95% 0.04054 mg/L 0.04555 mg/L 0.890010976948408 +DTXSID5025732 Css 3compartmentss Human 95% 0.3565 mg/L 4.964 mg/L 0.0718170829975826 +DTXSID5025738 Css 3compartmentss Human 95% 10.73 mg/L 9.083 mg/L 1.18132775514698 +DTXSID5025815 Css 3compartmentss Human 95% 1.082 mg/L 2.398 mg/L 0.451209341117598 +DTXSID5025861 Css 3compartmentss Human 95% 1.579 mg/L 7.025 mg/L 0.224768683274021 +DTXSID5025863 Css 3compartmentss Human 95% 0.3533 mg/L 0.3186 mg/L 1.10891399874451 +DTXSID5025998 Css 3compartmentss Human 95% 10.11 mg/L 14.5 mg/L 0.697241379310345 +DTXSID5026097 Css 3compartmentss Human 95% 259.7 mg/L NA NA NA +DTXSID5026120 Css 3compartmentss Human 95% 2.077 mg/L 1.083 mg/L 1.91782086795937 +DTXSID5026124 Css 3compartmentss Human 95% 0.9534 mg/L 0.2698 mg/L 3.53372868791698 +DTXSID5026178 Css 3compartmentss Human 95% 8.209 mg/L 8.329 mg/L 0.985592508104214 +DTXSID5026203 Css 3compartmentss Human 95% 125.3 mg/L 126.7 mg/L 0.988950276243094 +DTXSID5026205 Css 3compartmentss Human 95% 126.3 mg/L 138.4 mg/L 0.91257225433526 +DTXSID5026207 Css 3compartmentss Human 95% 19.26 mg/L 50 mg/L 0.3852 +DTXSID5026209 Css 3compartmentss Human 95% 21.74 mg/L 208 mg/L 0.104519230769231 +DTXSID5026251 Css 3compartmentss Human 95% 20.78 mg/L 40.08 mg/L 0.518463073852296 +DTXSID5026259 Css 3compartmentss Human 95% 1.901 mg/L 0.1305 mg/L 14.5670498084291 +DTXSID5026544 Css 3compartmentss Human 95% 0.5179 mg/L 11.39 mg/L 0.0454697102721686 +DTXSID5026548 Css 3compartmentss Human 95% 6.479 mg/L 0.1675 mg/L 38.6805970149254 +DTXSID5026625 Css 3compartmentss Human 95% 1.197 mg/L 4.558 mg/L 0.262615182097411 +DTXSID5026702 Css 3compartmentss Human 95% 7.363 mg/L 0.03226 mg/L 228.239305641662 +DTXSID5026881 Css 3compartmentss Human 95% 8.996 mg/L 1876 mg/L 0.0047953091684435 +DTXSID5026912 Css 3compartmentss Human 95% 6.319 mg/L 5.03 mg/L 1.25626242544732 +DTXSID5026918 Css 3compartmentss Human 95% 17.21 mg/L 12.11 mg/L 1.42113955408753 +DTXSID5027063 Css 3compartmentss Human 95% 7.384 mg/L 11.38 mg/L 0.648857644991213 +DTXSID5027069 Css 3compartmentss Human 95% 0.3081 mg/L 5.639 mg/L 0.0546373470473488 +DTXSID5027192 Css 3compartmentss Human 95% 2.635 mg/L NA NA NA +DTXSID5027198 Css 3compartmentss Human 95% 0.6337 mg/L 0.0548 mg/L 11.5638686131387 +DTXSID5027279 Css 3compartmentss Human 95% 8.591 mg/L 9.805 mg/L 0.876185619581846 +DTXSID5027300 Css 3compartmentss Human 95% 0.9092 mg/L 1.115 mg/L 0.81542600896861 +DTXSID5027302 Css 3compartmentss Human 95% 252.7 mg/L 246.3 mg/L 1.02598457166058 +DTXSID5027308 Css 3compartmentss Human 95% 1.599 mg/L NA NA NA +DTXSID5027356 Css 3compartmentss Human 95% 7.848 mg/L 0.273 mg/L 28.7472527472527 +DTXSID5027358 Css 3compartmentss Human 95% 0.483 mg/L 9.237 mg/L 0.0522897044494966 +DTXSID5027433 Css 3compartmentss Human 95% 7.596 mg/L 0.01662 mg/L 457.039711191336 +DTXSID5027487 Css 3compartmentss Human 95% 7.666 mg/L 0.3625 mg/L 21.1475862068966 +DTXSID5027489 Css 3compartmentss Human 95% 0.4617 mg/L 0.119 mg/L 3.87983193277311 +DTXSID5027512 Css 3compartmentss Human 95% 6.269 mg/L 1.003 mg/L 6.25024925224327 +DTXSID5027564 Css 3compartmentss Human 95% 0.4723 mg/L NA NA NA +DTXSID5027641 Css 3compartmentss Human 95% 1.95 mg/L 0.535 mg/L 3.64485981308411 +DTXSID5027770 Css 3compartmentss Human 95% 0.07454 mg/L 1.066 mg/L 0.0699249530956848 +DTXSID5027772 Css 3compartmentss Human 95% 0.5071 mg/L 0.5559 mg/L 0.912214427055226 +DTXSID5027774 Css 3compartmentss Human 95% 5.074 mg/L 5.506 mg/L 0.921540138031239 +DTXSID5027803 Css 3compartmentss Human 95% 0.3115 mg/L 0.1871 mg/L 1.66488508818813 +DTXSID5027805 Css 3compartmentss Human 95% 0.7296 mg/L 0.7726 mg/L 0.944343774268703 +DTXSID50279249 Css 3compartmentss Human 95% 7.456 mg/L NA NA NA +DTXSID5028114 Css 3compartmentss Human 95% 0.4339 mg/L NA NA NA +DTXSID5029055 Css 3compartmentss Human 95% 3.738 mg/L 3.403 mg/L 1.09844255069057 +DTXSID5029136 Css 3compartmentss Human 95% 2.47 mg/L 43.69 mg/L 0.0565346761272602 +DTXSID5029182 Css 3compartmentss Human 95% 6.586 mg/L 7.742 mg/L 0.85068457762852 +DTXSID5029184 Css 3compartmentss Human 95% 8.104 mg/L 8.516 mg/L 0.951620479098168 +DTXSID5029186 Css 3compartmentss Human 95% 3.303 mg/L 4.225 mg/L 0.781775147928994 +DTXSID5029211 Css 3compartmentss Human 95% 8.816 mg/L 279.8 mg/L 0.0315082201572552 +DTXSID5029217 Css 3compartmentss Human 95% 5.857 mg/L 5.6 mg/L 1.04589285714286 +DTXSID5029263 Css 3compartmentss Human 95% 5.704 mg/L 5.576 mg/L 1.02295552367288 +DTXSID5029265 Css 3compartmentss Human 95% 1.944 mg/L 0.6386 mg/L 3.04415909802693 +DTXSID5029762 Css 3compartmentss Human 95% 5.744 mg/L 367.5 mg/L 0.0156299319727891 +DTXSID5030955 Css 3compartmentss Human 95% 0.7141 mg/L NA NA NA +DTXSID5031131 Css 3compartmentss Human 95% 1.751 mg/L 1.725 mg/L 1.01507246376812 +DTXSID5031133 Css 3compartmentss Human 95% 0.0662 mg/L 0.1115 mg/L 0.59372197309417 +DTXSID5031210 Css 3compartmentss Human 95% 6.019 mg/L 1.692 mg/L 3.55732860520095 +DTXSID50313051 Css 3compartmentss Human 95% 2.198 mg/L NA NA NA +DTXSID5032020 Css 3compartmentss Human 95% 4.924 mg/L 5.609 mg/L 0.877874844000713 +DTXSID5032315 Css 3compartmentss Human 95% 10.62 mg/L 90.15 mg/L 0.117803660565724 +DTXSID5032361 Css 3compartmentss Human 95% 2.86 mg/L 2.834 mg/L 1.00917431192661 +DTXSID5032365 Css 3compartmentss Human 95% 62.11 mg/L 77.69 mg/L 0.799459389882868 +DTXSID5032442 Css 3compartmentss Human 95% 1.253 mg/L 1.689 mg/L 0.74185908821788 +DTXSID5032498 Css 3compartmentss Human 95% 15.52 mg/L 16.43 mg/L 0.944613511868533 +DTXSID5032523 Css 3compartmentss Human 95% 1.902 mg/L 0.3145 mg/L 6.04769475357711 +DTXSID5032525 Css 3compartmentss Human 95% 0.9519 mg/L 0.6742 mg/L 1.4118955799466 +DTXSID5032577 Css 3compartmentss Human 95% 13.32 mg/L 12.76 mg/L 1.04388714733542 +DTXSID5032579 Css 3compartmentss Human 95% 0.2879 mg/L 0.2945 mg/L 0.977589134125637 +DTXSID5032600 Css 3compartmentss Human 95% 5.488 mg/L 5.726 mg/L 0.958435207823961 +DTXSID5032654 Css 3compartmentss Human 95% 11.31 mg/L 0.07849 mg/L 144.094789145114 +DTXSID5033096 Css 3compartmentss Human 95% 4.184 mg/L 4.872 mg/L 0.858784893267652 +DTXSID5033098 Css 3compartmentss Human 95% 7.583 mg/L 7.727 mg/L 0.981364048142876 +DTXSID5033179 Css 3compartmentss Human 95% 5.459 mg/L 6.233 mg/L 0.875822236483234 +DTXSID5033389 Css 3compartmentss Human 95% 7.52 mg/L 104.4 mg/L 0.0720306513409962 +DTXSID5033468 Css 3compartmentss Human 95% 2.384 mg/L 3.294 mg/L 0.723740133576199 +DTXSID5033595 Css 3compartmentss Human 95% 1.341 mg/L 0.9613 mg/L 1.39498595651722 +DTXSID5033674 Css 3compartmentss Human 95% 1.646 mg/L 0.04113 mg/L 40.0194505227328 +DTXSID5033757 Css 3compartmentss Human 95% 8.755 mg/L 86.32 mg/L 0.101424930491196 +DTXSID5033836 Css 3compartmentss Human 95% 7.502 mg/L 3.705 mg/L 2.02483130904184 +DTXSID50338966 Css 3compartmentss Human 95% 0.4055 mg/L NA NA NA +DTXSID5034141 Css 3compartmentss Human 95% 2.938 mg/L NA NA NA +DTXSID5034270 Css 3compartmentss Human 95% 8.4 mg/L 10.96 mg/L 0.766423357664234 +DTXSID5034303 Css 3compartmentss Human 95% 956.8 mg/L 721.7 mg/L 1.32575862546765 +DTXSID5034355 Css 3compartmentss Human 95% 17.08 mg/L 75.35 mg/L 0.226675514266755 +DTXSID5034357 Css 3compartmentss Human 95% 21.62 mg/L 10.94 mg/L 1.97623400365631 +DTXSID5034698 Css 3compartmentss Human 95% 21.88 mg/L 89.5 mg/L 0.244469273743017 +DTXSID5034723 Css 3compartmentss Human 95% 14.6 mg/L 19.49 mg/L 0.749102103642894 +DTXSID50347235 Css 3compartmentss Human 95% 8.378 mg/L NA NA NA +DTXSID5034729 Css 3compartmentss Human 95% 1.886 mg/L 1.624 mg/L 1.16133004926108 +DTXSID5034773 Css 3compartmentss Human 95% 152.3 mg/L 182.2 mg/L 0.83589462129528 +DTXSID5035080 Css 3compartmentss Human 95% 19.75 mg/L NA NA NA +DTXSID5035163 Css 3compartmentss Human 95% 0.4846 mg/L 0.01015 mg/L 47.743842364532 +DTXSID5035616 Css 3compartmentss Human 95% 0.8072 mg/L 12.55 mg/L 0.0643187250996016 +DTXSID5035957 Css 3compartmentss Human 95% 30.06 mg/L 29.48 mg/L 1.01967435549525 +DTXSID5036684 Css 3compartmentss Human 95% 9.212 mg/L 4.407 mg/L 2.09031086907193 +DTXSID5037072 Css 3compartmentss Human 95% 7.44 mg/L 11.19 mg/L 0.664879356568365 +DTXSID5037236 Css 3compartmentss Human 95% 5.155 mg/L NA NA NA +DTXSID5037494 Css 3compartmentss Human 95% 3.194 mg/L 3.279 mg/L 0.974077462641049 +DTXSID5037498 Css 3compartmentss Human 95% 7.148 mg/L 4.065 mg/L 1.75842558425584 +DTXSID5037523 Css 3compartmentss Human 95% 0.2435 mg/L 0.3176 mg/L 0.766687657430731 +DTXSID5037527 Css 3compartmentss Human 95% 2.01 mg/L 0.6067 mg/L 3.31300477995714 +DTXSID5037571 Css 3compartmentss Human 95% 0.5278 mg/L NA NA NA +DTXSID5037577 Css 3compartmentss Human 95% 11.18 mg/L 0.6596 mg/L 16.949666464524 +DTXSID5037579 Css 3compartmentss Human 95% 2.427 mg/L 1.233 mg/L 1.9683698296837 +DTXSID5037731 Css 3compartmentss Human 95% 345.9 mg/L 445.8 mg/L 0.775908479138627 +DTXSID5037739 Css 3compartmentss Human 95% 0.8566 mg/L 0.8435 mg/L 1.01553052756372 +DTXSID5038830 Css 3compartmentss Human 95% 14.77 mg/L NA NA NA +DTXSID5038888 Css 3compartmentss Human 95% 295.6 mg/L 126.7 mg/L 2.33307024467245 +DTXSID5038919 Css 3compartmentss Human 95% 0.5175 mg/L 2.124 mg/L 0.24364406779661 +DTXSID5039721 Css 3compartmentss Human 95% 129.9 mg/L 65.36 mg/L 1.9874541003672 +DTXSID5040413 Css 3compartmentss Human 95% 11.18 mg/L 12.52 mg/L 0.89297124600639 +DTXSID5040461 Css 3compartmentss Human 95% 0.3311 mg/L 6.25 mg/L 0.052976 +DTXSID5040465 Css 3compartmentss Human 95% 6.078 mg/L 3.864 mg/L 1.57298136645963 +DTXSID5040540 Css 3compartmentss Human 95% 6.353 mg/L 0.2021 mg/L 31.4349332013855 +DTXSID5040625 Css 3compartmentss Human 95% 40.58 mg/L 45.63 mg/L 0.889327197019505 +DTXSID5040675 Css 3compartmentss Human 95% 156.8 mg/L 263.2 mg/L 0.595744680851064 +DTXSID5040679 Css 3compartmentss Human 95% 17.5 mg/L 18 mg/L 0.972222222222222 +DTXSID5040704 Css 3compartmentss Human 95% 9.909 mg/L 2.9 mg/L 3.41689655172414 +DTXSID5040706 Css 3compartmentss Human 95% 9683 mg/L 13710 mg/L 0.706272793581328 +DTXSID5040708 Css 3compartmentss Human 95% 0.8732 mg/L 0.8408 mg/L 1.03853472882969 +DTXSID5040750 Css 3compartmentss Human 95% 10.05 mg/L 6.688 mg/L 1.50269138755981 +DTXSID5040758 Css 3compartmentss Human 95% 13.36 mg/L 108.5 mg/L 0.123133640552995 +DTXSID5041140 Css 3compartmentss Human 95% 20.17 mg/L NA NA NA +DTXSID5041148 Css 3compartmentss Human 95% 8.88 mg/L 5.032 mg/L 1.76470588235294 +DTXSID5041190 Css 3compartmentss Human 95% 1.515 mg/L NA NA NA +DTXSID5041273 Css 3compartmentss Human 95% 7.716 mg/L 10.89 mg/L 0.708539944903581 +DTXSID5041275 Css 3compartmentss Human 95% 5.418 mg/L 186 mg/L 0.0291290322580645 +DTXSID5041279 Css 3compartmentss Human 95% 8.099 mg/L 2.362 mg/L 3.42887383573243 +DTXSID5041306 Css 3compartmentss Human 95% 5.408 mg/L 5.578 mg/L 0.969523126568663 +DTXSID5041308 Css 3compartmentss Human 95% 17.28 mg/L 14.76 mg/L 1.17073170731707 +DTXSID5041356 Css 3compartmentss Human 95% 194.2 mg/L 64.55 mg/L 3.00852052672347 +DTXSID5041431 Css 3compartmentss Human 95% 0.6943 mg/L 1.471 mg/L 0.47199184228416 +DTXSID5041437 Css 3compartmentss Human 95% 0.3764 mg/L 0.4344 mg/L 0.866482504604052 +DTXSID5041439 Css 3compartmentss Human 95% 6.529 mg/L 14.49 mg/L 0.450586611456177 +DTXSID5041512 Css 3compartmentss Human 95% 0.5516 mg/L 6.747 mg/L 0.0817548540091893 +DTXSID5041516 Css 3compartmentss Human 95% 0.05732 mg/L 0.06254 mg/L 0.916533418612088 +DTXSID5041518 Css 3compartmentss Human 95% 0.4031 mg/L 0.1242 mg/L 3.24557165861514 +DTXSID5041641 Css 3compartmentss Human 95% 1.126 mg/L 8.009 mg/L 0.14059183418654 +DTXSID5041643 Css 3compartmentss Human 95% 7.089 mg/L 2.592 mg/L 2.7349537037037 +DTXSID5041691 Css 3compartmentss Human 95% 2.093 mg/L 2.186 mg/L 0.957456541628545 +DTXSID5041697 Css 3compartmentss Human 95% 2.389 mg/L 0.9125 mg/L 2.61808219178082 +DTXSID5041699 Css 3compartmentss Human 95% 2.403 mg/L 2.064 mg/L 1.16424418604651 +DTXSID5041726 Css 3compartmentss Human 95% 3544 mg/L 5406 mg/L 0.655567887532371 +DTXSID5041728 Css 3compartmentss Human 95% 3.416 mg/L 129 mg/L 0.0264806201550388 +DTXSID5041772 Css 3compartmentss Human 95% 19.93 mg/L 15.93 mg/L 1.2510985561833 +DTXSID5041774 Css 3compartmentss Human 95% 2.436 mg/L 5.593 mg/L 0.435544430538173 +DTXSID5041778 Css 3compartmentss Human 95% 21.02 mg/L 27.38 mg/L 0.767713659605551 +DTXSID5041809 Css 3compartmentss Human 95% 6.369 mg/L 9.421 mg/L 0.676042882921134 +DTXSID5041851 Css 3compartmentss Human 95% 7.476 mg/L 17.41 mg/L 0.429408385985066 +DTXSID5042035 Css 3compartmentss Human 95% 10.4 mg/L NA NA NA +DTXSID5042039 Css 3compartmentss Human 95% 4.791 mg/L NA NA NA +DTXSID5042083 Css 3compartmentss Human 95% 16.04 mg/L 3.303 mg/L 4.85619134120496 +DTXSID5042089 Css 3compartmentss Human 95% 11.44 mg/L 26.02 mg/L 0.439661798616449 +DTXSID5042243 Css 3compartmentss Human 95% 130.5 mg/L 244.1 mg/L 0.534616960262188 +DTXSID5042297 Css 3compartmentss Human 95% 14.58 mg/L 0.9161 mg/L 15.915293090274 +DTXSID5042299 Css 3compartmentss Human 95% 2.197 mg/L 2.65 mg/L 0.829056603773585 +DTXSID5042322 Css 3compartmentss Human 95% 3.941 mg/L 568 mg/L 0.00693838028169014 +DTXSID5042324 Css 3compartmentss Human 95% 12.5 mg/L 257.8 mg/L 0.0484871993793638 +DTXSID5042584 Css 3compartmentss Human 95% 0.8238 mg/L 4.031 mg/L 0.20436616224262 +DTXSID5042613 Css 3compartmentss Human 95% 0.562 mg/L 0.3574 mg/L 1.57246782316732 +DTXSID5043714 Css 3compartmentss Human 95% 6.61 mg/L 2.8 mg/L 2.36071428571429 +DTXSID5043895 Css 3compartmentss Human 95% 10.19 mg/L 4.404 mg/L 2.31380563124432 +DTXSID5043897 Css 3compartmentss Human 95% 2.167 mg/L 2.855 mg/L 0.759019264448336 +DTXSID5044023 Css 3compartmentss Human 95% 0.3876 mg/L 0.03752 mg/L 10.3304904051173 +DTXSID5044029 Css 3compartmentss Human 95% 60.91 mg/L 53.7 mg/L 1.13426443202979 +DTXSID5044154 Css 3compartmentss Human 95% 4.164 mg/L 4.494 mg/L 0.926568758344459 +DTXSID5044233 Css 3compartmentss Human 95% 3.663 mg/L 0.001232 mg/L 2973.21428571429 +DTXSID5044239 Css 3compartmentss Human 95% 0.9303 mg/L 3.343 mg/L 0.278282979359856 +DTXSID5044281 Css 3compartmentss Human 95% 1.51 mg/L NA NA NA +DTXSID5044289 Css 3compartmentss Human 95% 0.7458 mg/L 0.5415 mg/L 1.37728531855956 +DTXSID5044314 Css 3compartmentss Human 95% 1.919 mg/L 0.2216 mg/L 8.65974729241877 +DTXSID5044316 Css 3compartmentss Human 95% 0.3861 mg/L 7.666 mg/L 0.0503652491521002 +DTXSID5044362 Css 3compartmentss Human 95% 6.227 mg/L 5.786 mg/L 1.07621845834774 +DTXSID5044447 Css 3compartmentss Human 95% 0.5236 mg/L 0.1465 mg/L 3.5740614334471 +DTXSID5044491 Css 3compartmentss Human 95% 3.325 mg/L 5.546 mg/L 0.599531193653083 +DTXSID5044493 Css 3compartmentss Human 95% 7.307 mg/L 0.1687 mg/L 43.3135743924126 +DTXSID5044495 Css 3compartmentss Human 95% 0.3254 mg/L 0.3074 mg/L 1.05855562784645 +DTXSID5044520 Css 3compartmentss Human 95% 365.9 mg/L 6356 mg/L 0.0575676526117055 +DTXSID5044522 Css 3compartmentss Human 95% 8.415 mg/L 0.738 mg/L 11.4024390243902 +DTXSID5044526 Css 3compartmentss Human 95% 1.198 mg/L 1.987 mg/L 0.602918973326623 +DTXSID5044528 Css 3compartmentss Human 95% 174.4 mg/L 162.6 mg/L 1.07257072570726 +DTXSID5044570 Css 3compartmentss Human 95% 4.777 mg/L 5.503 mg/L 0.868071960748683 +DTXSID5044574 Css 3compartmentss Human 95% 1.32 mg/L NA NA NA +DTXSID5044576 Css 3compartmentss Human 95% 0.4003 mg/L 0.1889 mg/L 2.11911064055056 +DTXSID5044578 Css 3compartmentss Human 95% 0.6857 mg/L 8.009 mg/L 0.0856161817954801 +DTXSID5044603 Css 3compartmentss Human 95% 6.402 mg/L 1.319 mg/L 4.85367702805155 +DTXSID5044605 Css 3compartmentss Human 95% 16.01 mg/L 22.05 mg/L 0.726077097505669 +DTXSID5044607 Css 3compartmentss Human 95% 2.607 mg/L 0.8867 mg/L 2.94011503326943 +DTXSID5044732 Css 3compartmentss Human 95% 2.474 mg/L NA NA NA +DTXSID5044734 Css 3compartmentss Human 95% 8.095 mg/L 2.746 mg/L 2.94792425345958 +DTXSID5044738 Css 3compartmentss Human 95% 1.727 mg/L 0.6823 mg/L 2.53114465777517 +DTXSID5044782 Css 3compartmentss Human 95% 4.644 mg/L 74.07 mg/L 0.0626974483596598 +DTXSID5044784 Css 3compartmentss Human 95% 0.8893 mg/L 4.659 mg/L 0.190877870787723 +DTXSID5044786 Css 3compartmentss Human 95% 2.186 mg/L 8.834 mg/L 0.247453022413403 +DTXSID5044788 Css 3compartmentss Human 95% 2.144 mg/L 11.45 mg/L 0.187248908296943 +DTXSID5044815 Css 3compartmentss Human 95% 11.05 mg/L 28.85 mg/L 0.383015597920277 +DTXSID5044817 Css 3compartmentss Human 95% 15.7 mg/L 46.62 mg/L 0.336765336765337 +DTXSID5044819 Css 3compartmentss Human 95% 8.198 mg/L 9.51 mg/L 0.862039957939012 +DTXSID5044863 Css 3compartmentss Human 95% 7.706 mg/L 1.935 mg/L 3.98242894056848 +DTXSID5044865 Css 3compartmentss Human 95% 10.2 mg/L 52.24 mg/L 0.195252679938744 +DTXSID5044867 Css 3compartmentss Human 95% 0.8731 mg/L 13.44 mg/L 0.0649627976190476 +DTXSID5044940 Css 3compartmentss Human 95% 12.78 mg/L 11.38 mg/L 1.12302284710018 +DTXSID5044948 Css 3compartmentss Human 95% 4.503 mg/L 0.4906 mg/L 9.17855686913983 +DTXSID5044992 Css 3compartmentss Human 95% 13.09 mg/L 28.47 mg/L 0.459782226905515 +DTXSID5044994 Css 3compartmentss Human 95% 14.27 mg/L 53.56 mg/L 0.266430171769978 +DTXSID5044998 Css 3compartmentss Human 95% 3.355 mg/L 5.481 mg/L 0.612114577631819 +DTXSID5045043 Css 3compartmentss Human 95% 5.568 mg/L 5.896 mg/L 0.944369063772049 +DTXSID5045091 Css 3compartmentss Human 95% 8.363 mg/L 2.604 mg/L 3.2115975422427 +DTXSID5045093 Css 3compartmentss Human 95% 0.5939 mg/L 7.447 mg/L 0.0797502349939573 +DTXSID5045099 Css 3compartmentss Human 95% 0.8961 mg/L 1.673 mg/L 0.535624626419606 +DTXSID5045120 Css 3compartmentss Human 95% 4.671 mg/L 3.702 mg/L 1.26175040518639 +DTXSID5045122 Css 3compartmentss Human 95% 0.4432 mg/L 0.8121 mg/L 0.545745597832779 +DTXSID5045124 Css 3compartmentss Human 95% 17.59 mg/L 297.5 mg/L 0.0591260504201681 +DTXSID5045128 Css 3compartmentss Human 95% 0.9684 mg/L 0.3743 mg/L 2.58722949505744 +DTXSID5045170 Css 3compartmentss Human 95% 0.7136 mg/L 0.7038 mg/L 1.01392441034385 +DTXSID5045172 Css 3compartmentss Human 95% 1.835 mg/L NA NA NA +DTXSID5045174 Css 3compartmentss Human 95% 0.1875 mg/L 0.2477 mg/L 0.756964069438837 +DTXSID5045176 Css 3compartmentss Human 95% 25.07 mg/L 4.088 mg/L 6.1325831702544 +DTXSID5045178 Css 3compartmentss Human 95% 24.1 mg/L 153.2 mg/L 0.157310704960836 +DTXSID5045201 Css 3compartmentss Human 95% 0.3419 mg/L 0.8619 mg/L 0.396681749622926 +DTXSID5045203 Css 3compartmentss Human 95% 0.3561 mg/L 0.01323 mg/L 26.9160997732426 +DTXSID5045205 Css 3compartmentss Human 95% 6.475 mg/L 0.8327 mg/L 7.77590969136544 +DTXSID5045209 Css 3compartmentss Human 95% 3.623 mg/L 1.39 mg/L 2.60647482014389 +DTXSID5045330 Css 3compartmentss Human 95% 1.734 mg/L 0.1841 mg/L 9.41879413362303 +DTXSID5045332 Css 3compartmentss Human 95% 3.759 mg/L 2.636 mg/L 1.42602427921093 +DTXSID5045380 Css 3compartmentss Human 95% 7.512 mg/L 0.1202 mg/L 62.495840266223 +DTXSID5045382 Css 3compartmentss Human 95% 5.48 mg/L 8.032 mg/L 0.682270916334661 +DTXSID5045384 Css 3compartmentss Human 95% 0.9544 mg/L 0.7196 mg/L 1.32629238465814 +DTXSID5045386 Css 3compartmentss Human 95% 6.915 mg/L 0.3715 mg/L 18.6137281292059 +DTXSID5045388 Css 3compartmentss Human 95% 6.142 mg/L 5.653 mg/L 1.08650274190695 +DTXSID5045413 Css 3compartmentss Human 95% 2.207 mg/L 1.428 mg/L 1.54551820728291 +DTXSID5045417 Css 3compartmentss Human 95% 8.218 mg/L 1.321 mg/L 6.22104466313399 +DTXSID5045419 Css 3compartmentss Human 95% 0.819 mg/L 1.42 mg/L 0.576760563380282 +DTXSID5045461 Css 3compartmentss Human 95% 0.9353 mg/L 4.217 mg/L 0.221792743656628 +DTXSID5045463 Css 3compartmentss Human 95% 0.8004 mg/L 0.02462 mg/L 32.5101543460601 +DTXSID5045465 Css 3compartmentss Human 95% 4.476 mg/L 5.403 mg/L 0.828428650749584 +DTXSID5045467 Css 3compartmentss Human 95% 0.4077 mg/L 0.09964 mg/L 4.09173022882377 +DTXSID5045469 Css 3compartmentss Human 95% 106.6 mg/L 104.3 mg/L 1.02205177372963 +DTXSID5045540 Css 3compartmentss Human 95% 0.3463 mg/L 1.956 mg/L 0.177044989775051 +DTXSID5045544 Css 3compartmentss Human 95% 5.487 mg/L 0.06913 mg/L 79.372197309417 +DTXSID5045546 Css 3compartmentss Human 95% 3.343 mg/L 14.36 mg/L 0.232799442896936 +DTXSID5045590 Css 3compartmentss Human 95% 6.526 mg/L 0.3338 mg/L 19.5506291192331 +DTXSID5045594 Css 3compartmentss Human 95% 5.18 mg/L 179.3 mg/L 0.0288901282766313 +DTXSID5045598 Css 3compartmentss Human 95% 1.785 mg/L 3.096 mg/L 0.576550387596899 +DTXSID5045623 Css 3compartmentss Human 95% 1.84 mg/L 35.25 mg/L 0.0521985815602837 +DTXSID5045625 Css 3compartmentss Human 95% 0.4481 mg/L 2.211 mg/L 0.202668475802804 +DTXSID5045671 Css 3compartmentss Human 95% 1.902 mg/L 0.3942 mg/L 4.82496194824962 +DTXSID5045673 Css 3compartmentss Human 95% 6.693 mg/L 0.9541 mg/L 7.01498794675611 +DTXSID5045675 Css 3compartmentss Human 95% 4.313 mg/L 5.788 mg/L 0.745162404975812 +DTXSID5045677 Css 3compartmentss Human 95% 1.597 mg/L 0.8949 mg/L 1.78455693373561 +DTXSID5045679 Css 3compartmentss Human 95% 0.9797 mg/L 3.343 mg/L 0.293060125635657 +DTXSID5045700 Css 3compartmentss Human 95% 5.129 mg/L 26.23 mg/L 0.195539458635151 +DTXSID5045702 Css 3compartmentss Human 95% 1.232 mg/L 0.8787 mg/L 1.40207124160692 +DTXSID5045704 Css 3compartmentss Human 95% 1.385 mg/L 0.5618 mg/L 2.46529013883944 +DTXSID5045706 Css 3compartmentss Human 95% 0.9056 mg/L 0.0699 mg/L 12.9556509298999 +DTXSID5045708 Css 3compartmentss Human 95% 8.387 mg/L 0.1536 mg/L 54.6028645833333 +DTXSID5045752 Css 3compartmentss Human 95% 1.981 mg/L 3.156 mg/L 0.627693282636248 +DTXSID5045756 Css 3compartmentss Human 95% 6.862 mg/L 2 mg/L 3.431 +DTXSID5045758 Css 3compartmentss Human 95% 1.246 mg/L 0.3067 mg/L 4.06260189109879 +DTXSID5045831 Css 3compartmentss Human 95% 32.47 mg/L 350.5 mg/L 0.0926390870185449 +DTXSID5045833 Css 3compartmentss Human 95% 4.383 mg/L 5.262 mg/L 0.832953249714937 +DTXSID5045835 Css 3compartmentss Human 95% 1.254 mg/L 5.533 mg/L 0.226640159045726 +DTXSID5045881 Css 3compartmentss Human 95% 0.02265 mg/L 0.05034 mg/L 0.449940405244338 +DTXSID5045883 Css 3compartmentss Human 95% 5.345 mg/L 0.6666 mg/L 8.01830183018302 +DTXSID5045885 Css 3compartmentss Human 95% 0.8346 mg/L 5.401 mg/L 0.154526939455656 +DTXSID5045887 Css 3compartmentss Human 95% 0.2676 mg/L 9.442 mg/L 0.0283414530819742 +DTXSID5045889 Css 3compartmentss Human 95% 19.78 mg/L 0.4942 mg/L 40.0242816673412 +DTXSID5045910 Css 3compartmentss Human 95% 3.401 mg/L 1.627 mg/L 2.09035033804548 +DTXSID5045914 Css 3compartmentss Human 95% 2.855 mg/L 5.583 mg/L 0.511373813361992 +DTXSID5045916 Css 3compartmentss Human 95% 1.694 mg/L 0.1635 mg/L 10.3608562691131 +DTXSID5045960 Css 3compartmentss Human 95% 15.98 mg/L 133.2 mg/L 0.11996996996997 +DTXSID5045962 Css 3compartmentss Human 95% 9.749 mg/L 2.501 mg/L 3.89804078368653 +DTXSID5045964 Css 3compartmentss Human 95% 16.1 mg/L 12.27 mg/L 1.3121434392828 +DTXSID5046013 Css 3compartmentss Human 95% 3.751 mg/L 6.172 mg/L 0.607744653272845 +DTXSID5046015 Css 3compartmentss Human 95% 3.183 mg/L 5.733 mg/L 0.555206698063841 +DTXSID5046017 Css 3compartmentss Human 95% 1.201 mg/L 6.606 mg/L 0.181804420224039 +DTXSID5046019 Css 3compartmentss Human 95% 3.421 mg/L 8.852 mg/L 0.38646633529146 +DTXSID5046061 Css 3compartmentss Human 95% 1.592 mg/L 1.27 mg/L 1.25354330708661 +DTXSID5046063 Css 3compartmentss Human 95% 1.03 mg/L 0.4085 mg/L 2.52141982864137 +DTXSID5046067 Css 3compartmentss Human 95% 8.343 mg/L 3.486 mg/L 2.39328743545611 +DTXSID5046069 Css 3compartmentss Human 95% 20.22 mg/L 4.694 mg/L 4.30762675756285 +DTXSID5046140 Css 3compartmentss Human 95% 12.35 mg/L NA NA NA +DTXSID5046142 Css 3compartmentss Human 95% 0.5325 mg/L 4.561 mg/L 0.116750712563034 +DTXSID5046144 Css 3compartmentss Human 95% 0.6891 mg/L 0.1064 mg/L 6.4765037593985 +DTXSID5046148 Css 3compartmentss Human 95% 4.973 mg/L 2.082 mg/L 2.38856868395773 +DTXSID5046190 Css 3compartmentss Human 95% 1.77 mg/L 3.425 mg/L 0.516788321167883 +DTXSID5046192 Css 3compartmentss Human 95% 2.78 mg/L 11.98 mg/L 0.232053422370618 +DTXSID5046194 Css 3compartmentss Human 95% 0.3255 mg/L NA NA NA +DTXSID5046196 Css 3compartmentss Human 95% 5.04 mg/L 5.537 mg/L 0.910240202275601 +DTXSID5046198 Css 3compartmentss Human 95% 11.05 mg/L 0.02715 mg/L 406.998158379374 +DTXSID5046221 Css 3compartmentss Human 95% 4.831 mg/L 0.6903 mg/L 6.99840648993191 +DTXSID5046223 Css 3compartmentss Human 95% 6.667 mg/L 2.097 mg/L 3.1793037672866 +DTXSID5046225 Css 3compartmentss Human 95% 25.34 mg/L 1327 mg/L 0.019095704596835 +DTXSID5046227 Css 3compartmentss Human 95% 46.51 mg/L 19.9 mg/L 2.33718592964824 +DTXSID5046229 Css 3compartmentss Human 95% 3.394 mg/L 64.48 mg/L 0.052636476426799 +DTXSID5046271 Css 3compartmentss Human 95% 0.8301 mg/L 0.7718 mg/L 1.07553770406841 +DTXSID5046273 Css 3compartmentss Human 95% 2.565 mg/L 15.35 mg/L 0.167100977198697 +DTXSID5046275 Css 3compartmentss Human 95% 4.489 mg/L 9.861 mg/L 0.455227664537065 +DTXSID5046277 Css 3compartmentss Human 95% 4.905 mg/L 51.03 mg/L 0.0961199294532628 +DTXSID5046279 Css 3compartmentss Human 95% 6.404 mg/L 15.23 mg/L 0.42048588312541 +DTXSID5046300 Css 3compartmentss Human 95% 12.63 mg/L 10.86 mg/L 1.16298342541436 +DTXSID5046306 Css 3compartmentss Human 95% 0.9523 mg/L 0.166 mg/L 5.73674698795181 +DTXSID5046352 Css 3compartmentss Human 95% 8.921 mg/L 1.275 mg/L 6.99686274509804 +DTXSID5046354 Css 3compartmentss Human 95% 631.8 mg/L 680.7 mg/L 0.928162185985015 +DTXSID5046356 Css 3compartmentss Human 95% 3.378 mg/L 4.95 mg/L 0.682424242424242 +DTXSID5046358 Css 3compartmentss Human 95% 67.96 mg/L 323.8 mg/L 0.209882643607165 +DTXSID5046433 Css 3compartmentss Human 95% 2.292 mg/L 3.215 mg/L 0.712908242612753 +DTXSID5046435 Css 3compartmentss Human 95% 4.986 mg/L 5.098 mg/L 0.978030600235386 +DTXSID5046437 Css 3compartmentss Human 95% 7.003 mg/L 8.064 mg/L 0.868427579365079 +DTXSID5046439 Css 3compartmentss Human 95% 46.99 mg/L 48.36 mg/L 0.971670802315964 +DTXSID5046481 Css 3compartmentss Human 95% 2.197 mg/L 85.24 mg/L 0.0257742843735336 +DTXSID5046483 Css 3compartmentss Human 95% 1.252 mg/L 22.22 mg/L 0.0563456345634563 +DTXSID5046485 Css 3compartmentss Human 95% 1.445 mg/L 1.07 mg/L 1.35046728971963 +DTXSID5046487 Css 3compartmentss Human 95% 1.224 mg/L 4.988 mg/L 0.245388933440257 +DTXSID5046489 Css 3compartmentss Human 95% 0.8071 mg/L 0.2958 mg/L 2.72853279242732 +DTXSID5046510 Css 3compartmentss Human 95% 5.121 mg/L 5.489 mg/L 0.932956822736382 +DTXSID5046512 Css 3compartmentss Human 95% 7.064 mg/L 5.263 mg/L 1.34220026600798 +DTXSID5046562 Css 3compartmentss Human 95% 6.019 mg/L 1.692 mg/L 3.55732860520095 +DTXSID5046564 Css 3compartmentss Human 95% 3.324 mg/L 73.81 mg/L 0.0450345481642054 +DTXSID5046568 Css 3compartmentss Human 95% 4.831 mg/L 8.43 mg/L 0.573072360616845 +DTXSID5046641 Css 3compartmentss Human 95% 3.471 mg/L 0.09906 mg/L 35.0393700787402 +DTXSID5046643 Css 3compartmentss Human 95% 4.836 mg/L 8.075 mg/L 0.598885448916409 +DTXSID5046647 Css 3compartmentss Human 95% 4.343 mg/L 1.65 mg/L 2.63212121212121 +DTXSID5046649 Css 3compartmentss Human 95% 6.788 mg/L 23.96 mg/L 0.28330550918197 +DTXSID5046691 Css 3compartmentss Human 95% 21.6 mg/L 12.94 mg/L 1.66924265842349 +DTXSID5046693 Css 3compartmentss Human 95% 1.405 mg/L 0.4705 mg/L 2.98618490967056 +DTXSID5046695 Css 3compartmentss Human 95% 1.074 mg/L 2.531 mg/L 0.424338206242592 +DTXSID5046697 Css 3compartmentss Human 95% 0.4104 mg/L 1.061 mg/L 0.386804901036758 +DTXSID5046699 Css 3compartmentss Human 95% 0.8994 mg/L 0.1456 mg/L 6.1771978021978 +DTXSID5046720 Css 3compartmentss Human 95% 141 mg/L 3022 mg/L 0.0466578424884183 +DTXSID5046722 Css 3compartmentss Human 95% 1.664 mg/L 31.59 mg/L 0.0526748971193416 +DTXSID5046724 Css 3compartmentss Human 95% 16.19 mg/L 12.44 mg/L 1.30144694533762 +DTXSID5046726 Css 3compartmentss Human 95% 3.459 mg/L 4.156 mg/L 0.832290664100096 +DTXSID5046728 Css 3compartmentss Human 95% 2.568 mg/L 40.77 mg/L 0.0629874908020603 +DTXSID5046770 Css 3compartmentss Human 95% 1.053 mg/L 0.7273 mg/L 1.4478207067235 +DTXSID5046772 Css 3compartmentss Human 95% 11.82 mg/L 6.489 mg/L 1.82154415164124 +DTXSID5046776 Css 3compartmentss Human 95% 7.884 mg/L 236.2 mg/L 0.0333784928027096 +DTXSID5046778 Css 3compartmentss Human 95% 9.361 mg/L 14.26 mg/L 0.656451612903226 +DTXSID5046801 Css 3compartmentss Human 95% 38.02 mg/L 6.17 mg/L 6.16207455429498 +DTXSID5046803 Css 3compartmentss Human 95% 1.566 mg/L 3.476 mg/L 0.450517836593786 +DTXSID5046805 Css 3compartmentss Human 95% 1.61 mg/L 1.554 mg/L 1.03603603603604 +DTXSID5046807 Css 3compartmentss Human 95% 1099 mg/L 0.01402 mg/L 78388.0171184023 +DTXSID5046851 Css 3compartmentss Human 95% 22.05 mg/L 1564 mg/L 0.0140984654731458 +DTXSID5046853 Css 3compartmentss Human 95% 21.55 mg/L 90.04 mg/L 0.239338071968014 +DTXSID5046855 Css 3compartmentss Human 95% 0.6781 mg/L 0.005183 mg/L 130.831564730851 +DTXSID5046857 Css 3compartmentss Human 95% 3.705 mg/L 10.33 mg/L 0.358664085188771 +DTXSID5046859 Css 3compartmentss Human 95% 0.9277 mg/L 0.1478 mg/L 6.27672530446549 +DTXSID5046934 Css 3compartmentss Human 95% 1.045 mg/L NA NA NA +DTXSID5046938 Css 3compartmentss Human 95% 7.824 mg/L 3.257 mg/L 2.40221062327295 +DTXSID5046980 Css 3compartmentss Human 95% 6.028 mg/L 9.584 mg/L 0.628964941569282 +DTXSID5046986 Css 3compartmentss Human 95% 6.091 mg/L 7.144 mg/L 0.852603583426652 +DTXSID5046988 Css 3compartmentss Human 95% 5.04 mg/L 5.742 mg/L 0.877742946708464 +DTXSID5047031 Css 3compartmentss Human 95% 12.85 mg/L 9.315 mg/L 1.37949543746645 +DTXSID5047033 Css 3compartmentss Human 95% 4.769 mg/L NA mg/L NA +DTXSID5047037 Css 3compartmentss Human 95% 1.15 mg/L 30.32 mg/L 0.0379287598944591 +DTXSID5047039 Css 3compartmentss Human 95% 1.225 mg/L 8.876 mg/L 0.13801261829653 +DTXSID5047085 Css 3compartmentss Human 95% 6.649 mg/L 1.327 mg/L 5.01055011303693 +DTXSID5047087 Css 3compartmentss Human 95% 0.6047 mg/L 0.04888 mg/L 12.3711129296236 +DTXSID5047089 Css 3compartmentss Human 95% 0.4647 mg/L NA NA NA +DTXSID5047110 Css 3compartmentss Human 95% 17.42 mg/L 27.93 mg/L 0.623702112423917 +DTXSID5047116 Css 3compartmentss Human 95% 0.6891 mg/L 4.167 mg/L 0.165370770338373 +DTXSID5047164 Css 3compartmentss Human 95% 0.4209 mg/L 8.144 mg/L 0.0516822200392927 +DTXSID5047166 Css 3compartmentss Human 95% 0.5703 mg/L 0.6196 mg/L 0.920432537120723 +DTXSID5047168 Css 3compartmentss Human 95% 14.95 mg/L 20.39 mg/L 0.73320255026974 +DTXSID5047241 Css 3compartmentss Human 95% 3.477 mg/L 6.136 mg/L 0.566655801825293 +DTXSID5047243 Css 3compartmentss Human 95% 10.96 mg/L 102.5 mg/L 0.106926829268293 +DTXSID5047249 Css 3compartmentss Human 95% 12.42 mg/L 87.28 mg/L 0.142300641613199 +DTXSID5047291 Css 3compartmentss Human 95% 2.052 mg/L 0.4187 mg/L 4.90088368760449 +DTXSID5047295 Css 3compartmentss Human 95% 3.031 mg/L 3.6 mg/L 0.841944444444444 +DTXSID5047297 Css 3compartmentss Human 95% 13.2 mg/L 40.6 mg/L 0.32512315270936 +DTXSID5047299 Css 3compartmentss Human 95% 0.9193 mg/L 1.122 mg/L 0.81934046345811 +DTXSID5047320 Css 3compartmentss Human 95% 56.3 mg/L 85.79 mg/L 0.656253642615689 +DTXSID5047322 Css 3compartmentss Human 95% 14.7 mg/L 12.61 mg/L 1.16574147501983 +DTXSID5047324 Css 3compartmentss Human 95% 3.633 mg/L 2.923 mg/L 1.24290112897708 +DTXSID5047328 Css 3compartmentss Human 95% 6.795 mg/L 1364 mg/L 0.0049816715542522 +DTXSID5047372 Css 3compartmentss Human 95% 6.525 mg/L 21.72 mg/L 0.300414364640884 +DTXSID5047374 Css 3compartmentss Human 95% 6.849 mg/L NA NA NA +DTXSID5047376 Css 3compartmentss Human 95% 2.711 mg/L 474 mg/L 0.00571940928270042 +DTXSID5047451 Css 3compartmentss Human 95% 1.586 mg/L 45.13 mg/L 0.0351429204520275 +DTXSID5047453 Css 3compartmentss Human 95% 0.3863 mg/L NA NA NA +DTXSID5047459 Css 3compartmentss Human 95% 7.592 mg/L 10.61 mg/L 0.71555136663525 +DTXSID5047530 Css 3compartmentss Human 95% 1.055 mg/L 1.675 mg/L 0.629850746268657 +DTXSID5047538 Css 3compartmentss Human 95% 25.6 mg/L 4.616 mg/L 5.54592720970537 +DTXSID5047584 Css 3compartmentss Human 95% 11 mg/L 4.038 mg/L 2.72412085190688 +DTXSID5047611 Css 3compartmentss Human 95% 0.3739 mg/L 7.041 mg/L 0.0531032523789234 +DTXSID5047661 Css 3compartmentss Human 95% 0.6489 mg/L 1.191 mg/L 0.544836272040302 +DTXSID5047790 Css 3compartmentss Human 95% 0.5676 mg/L 1.179 mg/L 0.481424936386768 +DTXSID5047825 Css 3compartmentss Human 95% 6.382 mg/L 4.405 mg/L 1.44880817253121 +DTXSID5047879 Css 3compartmentss Human 95% 10.68 mg/L 4.432 mg/L 2.40974729241877 +DTXSID5047902 Css 3compartmentss Human 95% 4.689 mg/L 5.288 mg/L 0.886724659606657 +DTXSID5047956 Css 3compartmentss Human 95% 7.224 mg/L 147.1 mg/L 0.0491094493541808 +DTXSID5048180 Css 3compartmentss Human 95% 1.385 mg/L 1.379 mg/L 1.00435097897027 +DTXSID5048182 Css 3compartmentss Human 95% 11.35 mg/L NA NA NA +DTXSID5048184 Css 3compartmentss Human 95% 3.949 mg/L 3.861 mg/L 1.02279202279202 +DTXSID5048186 Css 3compartmentss Human 95% 35.39 mg/L 21 mg/L 1.6852380952381 +DTXSID5048211 Css 3compartmentss Human 95% 1.598 mg/L NA NA NA +DTXSID5048265 Css 3compartmentss Human 95% 1.083 mg/L NA NA NA +DTXSID5048340 Css 3compartmentss Human 95% 23.8 mg/L NA NA NA +DTXSID5048342 Css 3compartmentss Human 95% 1.168 mg/L NA NA NA +DTXSID5048390 Css 3compartmentss Human 95% 68.17 mg/L NA NA NA +DTXSID5048421 Css 3compartmentss Human 95% 5.411 mg/L 2.74 mg/L 1.97481751824817 +DTXSID5048506 Css 3compartmentss Human 95% 13.91 mg/L 9.559 mg/L 1.4551731352652 +DTXSID5048550 Css 3compartmentss Human 95% 1.014 mg/L NA NA NA +DTXSID5048633 Css 3compartmentss Human 95% 1.62 mg/L 0.02244 mg/L 72.192513368984 +DTXSID5048635 Css 3compartmentss Human 95% 4.516 mg/L 76.01 mg/L 0.0594132351006446 +DTXSID5048637 Css 3compartmentss Human 95% 0.8913 mg/L 10.14 mg/L 0.0878994082840237 +DTXSID5048639 Css 3compartmentss Human 95% 144.1 mg/L 60.06 mg/L 2.3992673992674 +DTXSID5048681 Css 3compartmentss Human 95% 7.265 mg/L 4.759 mg/L 1.52658121454087 +DTXSID5048685 Css 3compartmentss Human 95% 1.774 mg/L 5.526 mg/L 0.321027868259139 +DTXSID5048687 Css 3compartmentss Human 95% 0.0008908 mg/L 0.002802 mg/L 0.317915774446824 +DTXSID5048689 Css 3compartmentss Human 95% 1.569 mg/L 0.3064 mg/L 5.12075718015666 +DTXSID5048710 Css 3compartmentss Human 95% 8.193 mg/L 1.313 mg/L 6.23990860624524 +DTXSID5048712 Css 3compartmentss Human 95% 19.48 mg/L 1.204 mg/L 16.1794019933555 +DTXSID5048714 Css 3compartmentss Human 95% 0.3789 mg/L 2.375 mg/L 0.159536842105263 +DTXSID5048716 Css 3compartmentss Human 95% 9.467 mg/L 9.097 mg/L 1.040672749258 +DTXSID5048718 Css 3compartmentss Human 95% 4.48 mg/L 4.577 mg/L 0.978807078872624 +DTXSID5048760 Css 3compartmentss Human 95% 0.604 mg/L 8.605 mg/L 0.0701917489831493 +DTXSID5048762 Css 3compartmentss Human 95% 0.3427 mg/L 0.8917 mg/L 0.384322081417517 +DTXSID5048764 Css 3compartmentss Human 95% 10.39 mg/L 17.1 mg/L 0.607602339181286 +DTXSID5048766 Css 3compartmentss Human 95% 0.461 mg/L 4.346 mg/L 0.106074551311551 +DTXSID5048768 Css 3compartmentss Human 95% 0.9331 mg/L 0.882 mg/L 1.05793650793651 +DTXSID5048841 Css 3compartmentss Human 95% 3.634 mg/L 30.19 mg/L 0.12037098376946 +DTXSID5048843 Css 3compartmentss Human 95% 2.139 mg/L 6.002 mg/L 0.356381206264578 +DTXSID5048845 Css 3compartmentss Human 95% 4.762 mg/L 3.684 mg/L 1.29261672095548 +DTXSID5048847 Css 3compartmentss Human 95% 0.4591 mg/L 2.193 mg/L 0.209347925216598 +DTXSID5048849 Css 3compartmentss Human 95% 4.608 mg/L 7.625 mg/L 0.604327868852459 +DTXSID5048891 Css 3compartmentss Human 95% 0.9938 mg/L 0.3422 mg/L 2.9041496201052 +DTXSID5048893 Css 3compartmentss Human 95% 0.8153 mg/L 0.04219 mg/L 19.3244844749941 +DTXSID5048895 Css 3compartmentss Human 95% 0.9074 mg/L 0.7505 mg/L 1.20906062624917 +DTXSID5048897 Css 3compartmentss Human 95% 0.3632 mg/L 1.031 mg/L 0.352279340446169 +DTXSID5048899 Css 3compartmentss Human 95% 7.011 mg/L 0.4542 mg/L 15.4359313077939 +DTXSID5048920 Css 3compartmentss Human 95% 4.175 mg/L 1.047 mg/L 3.98758357211079 +DTXSID5048922 Css 3compartmentss Human 95% 1.105 mg/L 1.597 mg/L 0.691922354414527 +DTXSID5048924 Css 3compartmentss Human 95% 0.392 mg/L 7.38 mg/L 0.0531165311653117 +DTXSID5048926 Css 3compartmentss Human 95% 1.045 mg/L 1.347 mg/L 0.775798069784707 +DTXSID5048928 Css 3compartmentss Human 95% 0.7997 mg/L 2.509 mg/L 0.318732562774014 +DTXSID5048970 Css 3compartmentss Human 95% 20.15 mg/L 0.06883 mg/L 292.7502542496 +DTXSID5048972 Css 3compartmentss Human 95% 5.072 mg/L 5.486 mg/L 0.924535180459351 +DTXSID5048974 Css 3compartmentss Human 95% 8.339 mg/L 2.289 mg/L 3.6430755788554 +DTXSID5048976 Css 3compartmentss Human 95% 5.07 mg/L 5.575 mg/L 0.909417040358744 +DTXSID5049021 Css 3compartmentss Human 95% 2.232 mg/L 2.899 mg/L 0.769920662297344 +DTXSID5049025 Css 3compartmentss Human 95% 10.6 mg/L 102.5 mg/L 0.103414634146341 +DTXSID5049029 Css 3compartmentss Human 95% 5.909 mg/L 11.53 mg/L 0.512489158716392 +DTXSID5049071 Css 3compartmentss Human 95% 9.636 mg/L 301.5 mg/L 0.0319601990049751 +DTXSID5049073 Css 3compartmentss Human 95% 16.43 mg/L 21.49 mg/L 0.764541647277804 +DTXSID5049075 Css 3compartmentss Human 95% 0.5761 mg/L 2.988 mg/L 0.192804551539491 +DTXSID5049077 Css 3compartmentss Human 95% 14.64 mg/L 940.1 mg/L 0.0155728114030422 +DTXSID5049079 Css 3compartmentss Human 95% 0.00246 mg/L 0.005464 mg/L 0.450219619326501 +DTXSID5049239 Css 3compartmentss Human 95% 5.006 mg/L 5.933 mg/L 0.84375526714984 +DTXSID5049287 Css 3compartmentss Human 95% 10.16 mg/L 11.81 mg/L 0.860287891617273 +DTXSID5049316 Css 3compartmentss Human 95% 4.986 mg/L 3.071 mg/L 1.62357538261153 +DTXSID5049318 Css 3compartmentss Human 95% 7.513 mg/L 4.913 mg/L 1.52920822308162 +DTXSID5049362 Css 3compartmentss Human 95% 8.121 mg/L 4.203 mg/L 1.93219129193433 +DTXSID5049655 Css 3compartmentss Human 95% 6.338 mg/L NA NA NA +DTXSID5050426 Css 3compartmentss Human 95% 6.55 mg/L 0.06787 mg/L 96.5080300574628 +DTXSID5051440 Css 3compartmentss Human 95% 6.745 mg/L 0.1959 mg/L 34.430832057172 +DTXSID5051444 Css 3compartmentss Human 95% 30.45 mg/L 9 mg/L 3.38333333333333 +DTXSID5051446 Css 3compartmentss Human 95% 6.971 mg/L 1.624 mg/L 4.29248768472906 +DTXSID5051602 Css 3compartmentss Human 95% 1.682 mg/L NA NA NA +DTXSID5051650 Css 3compartmentss Human 95% 13570 mg/L 11980 mg/L 1.13272120200334 +DTXSID5051735 Css 3compartmentss Human 95% 1.049 mg/L NA NA NA +DTXSID5051999 Css 3compartmentss Human 95% 17.46 mg/L 28.41 mg/L 0.614572333685322 +DTXSID5052042 Css 3compartmentss Human 95% 0.7045 mg/L 1.289 mg/L 0.546547711404189 +DTXSID5052125 Css 3compartmentss Human 95% 1.758 mg/L NA NA NA +DTXSID5052254 Css 3compartmentss Human 95% 0.3195 mg/L 2.211 mg/L 0.144504748982361 +DTXSID5052460 Css 3compartmentss Human 95% 5.092 mg/L 14.91 mg/L 0.341515761234071 +DTXSID5052468 Css 3compartmentss Human 95% 6.317 mg/L NA NA NA +DTXSID5052591 Css 3compartmentss Human 95% 0.423 mg/L 0.1788 mg/L 2.36577181208054 +DTXSID5052593 Css 3compartmentss Human 95% 2.105 mg/L 2.004 mg/L 1.05039920159681 +DTXSID5052595 Css 3compartmentss Human 95% 1.8 mg/L 1.442 mg/L 1.24826629680999 +DTXSID5052597 Css 3compartmentss Human 95% 7.42 mg/L 5.494 mg/L 1.35056425191118 +DTXSID5052620 Css 3compartmentss Human 95% 0.5733 mg/L 0.05223 mg/L 10.9764503159104 +DTXSID5052626 Css 3compartmentss Human 95% 0.3808 mg/L NA NA NA +DTXSID5052672 Css 3compartmentss Human 95% 1.197 mg/L 4.558 mg/L 0.262615182097411 +DTXSID5052676 Css 3compartmentss Human 95% 22.43 mg/L NA NA NA +DTXSID5052838 Css 3compartmentss Human 95% 1.629 mg/L 19.72 mg/L 0.082606490872211 +DTXSID5052884 Css 3compartmentss Human 95% 5.699 mg/L 4.853 mg/L 1.17432515969503 +DTXSID5057620 Css 3compartmentss Human 95% 1.396 mg/L 0.9452 mg/L 1.47693609818028 +DTXSID5057622 Css 3compartmentss Human 95% 6.018 mg/L 0.5446 mg/L 11.0503121557106 +DTXSID5057624 Css 3compartmentss Human 95% 0.3276 mg/L 0.3294 mg/L 0.994535519125683 +DTXSID5057626 Css 3compartmentss Human 95% 1.057 mg/L 1.194 mg/L 0.885259631490787 +DTXSID5057628 Css 3compartmentss Human 95% 0.8644 mg/L 0.2227 mg/L 3.88145487202515 +DTXSID5057670 Css 3compartmentss Human 95% 0.6659 mg/L 0.09288 mg/L 7.16946597760551 +DTXSID5057672 Css 3compartmentss Human 95% 1.394 mg/L 1.712 mg/L 0.814252336448598 +DTXSID5057674 Css 3compartmentss Human 95% 2.927 mg/L 5.313 mg/L 0.550912855260681 +DTXSID5057676 Css 3compartmentss Human 95% 0.7504 mg/L 12.08 mg/L 0.0621192052980132 +DTXSID5057678 Css 3compartmentss Human 95% 8.541 mg/L 12.74 mg/L 0.670408163265306 +DTXSID5057701 Css 3compartmentss Human 95% 0.9033 mg/L 0.1288 mg/L 7.01319875776398 +DTXSID5057703 Css 3compartmentss Human 95% 3.902 mg/L 0.3648 mg/L 10.6962719298246 +DTXSID5057705 Css 3compartmentss Human 95% 5.629 mg/L 5.565 mg/L 1.0115004492363 +DTXSID5057709 Css 3compartmentss Human 95% 7.556 mg/L 19.98 mg/L 0.378178178178178 +DTXSID5057751 Css 3compartmentss Human 95% 0.2637 mg/L 1.54 mg/L 0.171233766233766 +DTXSID5057753 Css 3compartmentss Human 95% 13.03 mg/L 35.38 mg/L 0.368287167891464 +DTXSID5057755 Css 3compartmentss Human 95% 0.573 mg/L 0.7482 mg/L 0.765838011226945 +DTXSID5057757 Css 3compartmentss Human 95% 1.239 mg/L 2.624 mg/L 0.472179878048781 +DTXSID5057759 Css 3compartmentss Human 95% 1.508 mg/L 4.668 mg/L 0.323050556983719 +DTXSID5057830 Css 3compartmentss Human 95% 1.1 mg/L 5.511 mg/L 0.199600798403194 +DTXSID5057832 Css 3compartmentss Human 95% 8.899 mg/L 3.019 mg/L 2.94766478966545 +DTXSID5057834 Css 3compartmentss Human 95% 9.689 mg/L 10.96 mg/L 0.884032846715328 +DTXSID5057836 Css 3compartmentss Human 95% 4.764 mg/L 8.041 mg/L 0.592463623927372 +DTXSID5057838 Css 3compartmentss Human 95% 3.082 mg/L 7.603 mg/L 0.40536630277522 +DTXSID5057888 Css 3compartmentss Human 95% 0.5561 mg/L NA NA NA +DTXSID5058692 Css 3compartmentss Human 95% 7.564 mg/L NA NA NA +DTXSID5058694 Css 3compartmentss Human 95% 1.49 mg/L NA NA NA +DTXSID50588686 Css 3compartmentss Human 95% 1.924 mg/L NA NA NA +DTXSID5059242 Css 3compartmentss Human 95% 7.71 mg/L NA NA NA +DTXSID5060934 Css 3compartmentss Human 95% 17.63 mg/L NA NA NA +DTXSID5061532 Css 3compartmentss Human 95% 0.8494 mg/L NA NA NA +DTXSID5062184 Css 3compartmentss Human 95% 0.2253 mg/L NA NA NA +DTXSID5062974 Css 3compartmentss Human 95% 2.62 mg/L NA NA NA +DTXSID50648693 Css 3compartmentss Human 95% 5.053 mg/L NA NA NA +DTXSID50648931 Css 3compartmentss Human 95% 25.48 mg/L NA NA NA +DTXSID50701313 Css 3compartmentss Human 95% 6.105 mg/L NA NA NA +DTXSID50859181 Css 3compartmentss Human 95% 4.194 mg/L NA NA NA +DTXSID50861300 Css 3compartmentss Human 95% 68.38 mg/L 84.72 mg/L 0.807129367327668 +DTXSID50862110 Css 3compartmentss Human 95% 1.233 mg/L NA NA NA +DTXSID50862695 Css 3compartmentss Human 95% 3.238 mg/L NA NA NA +DTXSID50864917 Css 3compartmentss Human 95% 1.201 mg/L NA NA NA +DTXSID50865484 Css 3compartmentss Human 95% 0.3458 mg/L NA NA NA +DTXSID50868319 Css 3compartmentss Human 95% 0.9176 mg/L NA NA NA +DTXSID50869063 Css 3compartmentss Human 95% 2.547 mg/L NA NA NA +DTXSID50870351 Css 3compartmentss Human 95% 0.4195 mg/L 0.7692 mg/L 0.545371814872595 +DTXSID50872532 Css 3compartmentss Human 95% 7.194 mg/L NA NA NA +DTXSID50872976 Css 3compartmentss Human 95% 1.041 mg/L NA NA NA +DTXSID50873206 Css 3compartmentss Human 95% 6.7 mg/L NA NA NA +DTXSID50873362 Css 3compartmentss Human 95% 0.5987 mg/L NA NA NA +DTXSID50873367 Css 3compartmentss Human 95% 2.036 mg/L NA NA NA +DTXSID50873382 Css 3compartmentss Human 95% 235.9 mg/L 244.5 mg/L 0.964826175869121 +DTXSID50873387 Css 3compartmentss Human 95% 5.097 mg/L NA NA NA +DTXSID50880657 Css 3compartmentss Human 95% 1.622 mg/L NA NA NA +DTXSID50880677 Css 3compartmentss Human 95% 0.7193 mg/L NA NA NA +DTXSID50880692 Css 3compartmentss Human 95% 2.444 mg/L NA NA NA +DTXSID50880758 Css 3compartmentss Human 95% 0.9069 mg/L NA NA NA +DTXSID50880773 Css 3compartmentss Human 95% 6.772 mg/L NA NA NA +DTXSID50880859 Css 3compartmentss Human 95% 10.03 mg/L NA NA NA +DTXSID50880879 Css 3compartmentss Human 95% 0.5778 mg/L NA NA NA +DTXSID50880899 Css 3compartmentss Human 95% 10.55 mg/L NA NA NA +DTXSID50880910 Css 3compartmentss Human 95% 2.088 mg/L NA NA NA +DTXSID50880915 Css 3compartmentss Human 95% 20.68 mg/L NA NA NA +DTXSID50881205 Css 3compartmentss Human 95% 0.5759 mg/L NA NA NA +DTXSID50881220 Css 3compartmentss Human 95% 14.88 mg/L NA NA NA +DTXSID50895069 Css 3compartmentss Human 95% 4.812 mg/L NA NA NA +DTXSID50904761 Css 3compartmentss Human 95% 1.206 mg/L NA NA NA +DTXSID50957136 Css 3compartmentss Human 95% 44.63 mg/L NA NA NA +DTXSID50999410 Css 3compartmentss Human 95% 19.28 mg/L NA NA NA +DTXSID601003247 Css 3compartmentss Human 95% 1.612 mg/L NA NA NA +DTXSID601004469 Css 3compartmentss Human 95% 75.09 mg/L NA NA NA +DTXSID601006172 Css 3compartmentss Human 95% 3.532 mg/L NA NA NA +DTXSID601016509 Css 3compartmentss Human 95% 1.386 mg/L NA NA NA +DTXSID601024792 Css 3compartmentss Human 95% 0.8861 mg/L NA NA NA +DTXSID601027922 Css 3compartmentss Human 95% 28.06 mg/L NA NA NA +DTXSID601028120 Css 3compartmentss Human 95% 0.7534 mg/L NA NA NA +DTXSID601029847 Css 3compartmentss Human 95% 5.81 mg/L NA NA NA +DTXSID601101988 Css 3compartmentss Human 95% 0.7279 mg/L NA NA NA +DTXSID601103615 Css 3compartmentss Human 95% 6.828 mg/L NA NA NA +DTXSID601303401 Css 3compartmentss Human 95% 5.616 mg/L NA NA NA +DTXSID60146711 Css 3compartmentss Human 95% 18.83 mg/L NA NA NA +DTXSID60147142 Css 3compartmentss Human 95% 0.3929 mg/L NA NA NA +DTXSID60149803 Css 3compartmentss Human 95% 0.3969 mg/L NA NA NA +DTXSID60154659 Css 3compartmentss Human 95% 29.23 mg/L NA NA NA +DTXSID60155121 Css 3compartmentss Human 95% 3.775 mg/L NA NA NA +DTXSID60155565 Css 3compartmentss Human 95% 2.992 mg/L NA NA NA +DTXSID60161227 Css 3compartmentss Human 95% 3.581 mg/L NA NA NA +DTXSID60162779 Css 3compartmentss Human 95% 62.39 mg/L NA NA NA +DTXSID60165285 Css 3compartmentss Human 95% 12.53 mg/L NA NA NA +DTXSID60166035 Css 3compartmentss Human 95% 1.713 mg/L NA NA NA +DTXSID60170955 Css 3compartmentss Human 95% 13.25 mg/L NA NA NA +DTXSID60177444 Css 3compartmentss Human 95% 3.08 mg/L NA NA NA +DTXSID60180332 Css 3compartmentss Human 95% 1.274 mg/L NA NA NA +DTXSID60184390 Css 3compartmentss Human 95% 0.2766 mg/L NA NA NA +DTXSID60186273 Css 3compartmentss Human 95% 1.32 mg/L NA NA NA +DTXSID60190198 Css 3compartmentss Human 95% 19.81 mg/L NA NA NA +DTXSID60194378 Css 3compartmentss Human 95% 35.25 mg/L 40.98 mg/L 0.860175695461201 +DTXSID6020014 Css 3compartmentss Human 95% 11.13 mg/L 7.696 mg/L 1.44620582120582 +DTXSID6020062 Css 3compartmentss Human 95% 0.6377 mg/L 4.645 mg/L 0.137287405812702 +DTXSID6020064 Css 3compartmentss Human 95% 0.4968 mg/L 1.961 mg/L 0.253340132585416 +DTXSID6020066 Css 3compartmentss Human 95% 0.379 mg/L 0.5159 mg/L 0.734638495832526 +DTXSID6020068 Css 3compartmentss Human 95% 3.879 mg/L 3.962 mg/L 0.979050984351338 +DTXSID6020141 Css 3compartmentss Human 95% 1.619 mg/L 3.111 mg/L 0.520411443265831 +DTXSID6020143 Css 3compartmentss Human 95% 0.5004 mg/L 16.23 mg/L 0.0308317929759704 +DTXSID6020147 Css 3compartmentss Human 95% 8.091 mg/L 8.241 mg/L 0.981798325445941 +DTXSID6020149 Css 3compartmentss Human 95% 8.726 mg/L 0.2452 mg/L 35.5872756933116 +DTXSID6020193 Css 3compartmentss Human 95% 7.589 mg/L 7.61 mg/L 0.997240473061761 +DTXSID6020197 Css 3compartmentss Human 95% 1.825 mg/L 1.818 mg/L 1.0038503850385 +DTXSID6020220 Css 3compartmentss Human 95% 0.5765 mg/L 3.177 mg/L 0.18146049732452 +DTXSID6020222 Css 3compartmentss Human 95% 5.49 mg/L 2.522 mg/L 2.17684377478192 +DTXSID6020224 Css 3compartmentss Human 95% 5.149 mg/L 5.875 mg/L 0.876425531914894 +DTXSID6020274 Css 3compartmentss Human 95% 6.154 mg/L 5.211 mg/L 1.18096334676646 +DTXSID6020276 Css 3compartmentss Human 95% 8.124 mg/L 0.4978 mg/L 16.3198071514665 +DTXSID6020278 Css 3compartmentss Human 95% 2.979 mg/L 12.88 mg/L 0.231288819875776 +DTXSID6020355 Css 3compartmentss Human 95% 6.373 mg/L 9.421 mg/L 0.676467466298694 +DTXSID6020357 Css 3compartmentss Human 95% 5.738 mg/L 0.09476 mg/L 60.5529759392149 +DTXSID6020359 Css 3compartmentss Human 95% 0.308 mg/L 2.97 mg/L 0.103703703703704 +DTXSID6020432 Css 3compartmentss Human 95% 11.89 mg/L 1.001 mg/L 11.8781218781219 +DTXSID6020480 Css 3compartmentss Human 95% 0.008863 mg/L 0.00843 mg/L 1.05136417556346 +DTXSID6020484 Css 3compartmentss Human 95% 6.824 mg/L 2.645 mg/L 2.57996219281664 +DTXSID6020511 Css 3compartmentss Human 95% 1.067 mg/L 1.154 mg/L 0.924610051993068 +DTXSID6020513 Css 3compartmentss Human 95% 6.692 mg/L 7.282 mg/L 0.918978302664103 +DTXSID6020515 Css 3compartmentss Human 95% 4.919 mg/L 5.564 mg/L 0.884076204169662 +DTXSID6020517 Css 3compartmentss Human 95% 4.26 mg/L 4.809 mg/L 0.885839051777916 +DTXSID6020561 Css 3compartmentss Human 95% 2753 mg/L 2791 mg/L 0.986384808312433 +DTXSID60205756 Css 3compartmentss Human 95% 31.19 mg/L NA NA NA +DTXSID6020648 Css 3compartmentss Human 95% 328.9 mg/L 263.7 mg/L 1.24725066363292 +DTXSID6020690 Css 3compartmentss Human 95% 10960 mg/L 11210 mg/L 0.977698483496878 +DTXSID6020692 Css 3compartmentss Human 95% 8.623 mg/L 8.912 mg/L 0.967571813285458 +DTXSID6020694 Css 3compartmentss Human 95% 7.231 mg/L NA NA NA +DTXSID6020696 Css 3compartmentss Human 95% 6.237 mg/L 5.096 mg/L 1.2239010989011 +DTXSID6020721 Css 3compartmentss Human 95% 1.144 mg/L 0.708 mg/L 1.61581920903955 +DTXSID6020771 Css 3compartmentss Human 95% 81.96 mg/L 120.2 mg/L 0.681863560732113 +DTXSID6020777 Css 3compartmentss Human 95% 0.8288 mg/L 0.5897 mg/L 1.40546040359505 +DTXSID6020779 Css 3compartmentss Human 95% 10.67 mg/L 336.9 mg/L 0.0316711190264173 +DTXSID60207957 Css 3compartmentss Human 95% 9.841 mg/L NA NA NA +DTXSID6020802 Css 3compartmentss Human 95% 4.137 mg/L 5.08 mg/L 0.814370078740157 +DTXSID6020804 Css 3compartmentss Human 95% 2.785 mg/L 8.737 mg/L 0.318759299530731 +DTXSID6020856 Css 3compartmentss Human 95% 1.315 mg/L 1.541 mg/L 0.853341985723556 +DTXSID6020933 Css 3compartmentss Human 95% 6.239 mg/L 0.4693 mg/L 13.294268058811 +DTXSID6020939 Css 3compartmentss Human 95% 4.374 mg/L 5.124 mg/L 0.853629976580796 +DTXSID6020983 Css 3compartmentss Human 95% 22.77 mg/L NA NA NA +DTXSID6020985 Css 3compartmentss Human 95% 2.36 mg/L 2.006 mg/L 1.17647058823529 +DTXSID6021032 Css 3compartmentss Human 95% 0.3547 mg/L NA NA NA +DTXSID6021036 Css 3compartmentss Human 95% 4.618 mg/L NA NA NA +DTXSID6021080 Css 3compartmentss Human 95% 5.611 mg/L 5.736 mg/L 0.978207810320781 +DTXSID6021082 Css 3compartmentss Human 95% 2.544 mg/L 12.74 mg/L 0.199686028257457 +DTXSID6021086 Css 3compartmentss Human 95% 6.299 mg/L 6.186 mg/L 1.01826705463951 +DTXSID6021117 Css 3compartmentss Human 95% 3.202 mg/L 3.219 mg/L 0.994718856787822 +DTXSID6021163 Css 3compartmentss Human 95% 4.626 mg/L 7.48 mg/L 0.618449197860963 +DTXSID6021165 Css 3compartmentss Human 95% 1.104 mg/L 1.334 mg/L 0.827586206896552 +DTXSID6021240 Css 3compartmentss Human 95% 0.05461 mg/L 3.569 mg/L 0.0153012048192771 +DTXSID6021244 Css 3compartmentss Human 95% 69.34 mg/L 90.37 mg/L 0.767290029877172 +DTXSID6021246 Css 3compartmentss Human 95% 4.11 mg/L 0.2963 mg/L 13.8710766115424 +DTXSID6021248 Css 3compartmentss Human 95% 28.85 mg/L 28.06 mg/L 1.02815395580898 +DTXSID6021290 Css 3compartmentss Human 95% 12.74 mg/L 12.97 mg/L 0.982266769468003 +DTXSID6021292 Css 3compartmentss Human 95% 8.375 mg/L 7.922 mg/L 1.05718252966423 +DTXSID6021294 Css 3compartmentss Human 95% 0.8528 mg/L 1.048 mg/L 0.813740458015267 +DTXSID6021296 Css 3compartmentss Human 95% 10.96 mg/L 21.97 mg/L 0.498862084660901 +DTXSID6021321 Css 3compartmentss Human 95% 4.603 mg/L 7.63 mg/L 0.603276539973788 +DTXSID6021327 Css 3compartmentss Human 95% 25.93 mg/L 5.619 mg/L 4.61470012457733 +DTXSID6021371 Css 3compartmentss Human 95% 1.583 mg/L 0.5721 mg/L 2.76699877643769 +DTXSID6021373 Css 3compartmentss Human 95% 6.525 mg/L 6.63 mg/L 0.984162895927602 +DTXSID6021375 Css 3compartmentss Human 95% 11.97 mg/L 1.564 mg/L 7.653452685422 +DTXSID6021379 Css 3compartmentss Human 95% 10.23 mg/L 2.899 mg/L 3.52880303552949 +DTXSID6021404 Css 3compartmentss Human 95% 6.201 mg/L 0.496 mg/L 12.5020161290323 +DTXSID6021450 Css 3compartmentss Human 95% 8.638 mg/L 5.827 mg/L 1.48240947314227 +DTXSID6021456 Css 3compartmentss Human 95% 28.63 mg/L 50.24 mg/L 0.569864649681529 +DTXSID6021458 Css 3compartmentss Human 95% 8.099 mg/L 0.7719 mg/L 10.4922917476357 +DTXSID6021581 Css 3compartmentss Human 95% 4.574 mg/L 9.114 mg/L 0.501865262233926 +DTXSID6021583 Css 3compartmentss Human 95% 2.904 mg/L 3.37 mg/L 0.861721068249258 +DTXSID6021585 Css 3compartmentss Human 95% 6.587 mg/L 7.547 mg/L 0.872797137935604 +DTXSID6021610 Css 3compartmentss Human 95% 0.367 mg/L 14.19 mg/L 0.0258632840028189 +DTXSID6021616 Css 3compartmentss Human 95% 6.735 mg/L NA NA NA +DTXSID6021618 Css 3compartmentss Human 95% 1.453 mg/L 42.95 mg/L 0.0338300349243306 +DTXSID6021666 Css 3compartmentss Human 95% 10.19 mg/L 466 mg/L 0.0218669527896996 +DTXSID6021668 Css 3compartmentss Human 95% 6.215 mg/L 6.931 mg/L 0.896696003462704 +DTXSID6021741 Css 3compartmentss Human 95% 0.3006 mg/L 5.788 mg/L 0.0519350380096752 +DTXSID6021793 Css 3compartmentss Human 95% 52.7 mg/L 54.6 mg/L 0.965201465201465 +DTXSID6021795 Css 3compartmentss Human 95% 9.06 mg/L 11.85 mg/L 0.764556962025317 +DTXSID6021822 Css 3compartmentss Human 95% 5.572 mg/L 5.477 mg/L 1.01734526200475 +DTXSID6021824 Css 3compartmentss Human 95% 33.63 mg/L 33.62 mg/L 1.00029744199881 +DTXSID6021828 Css 3compartmentss Human 95% 6.896 mg/L 7.091 mg/L 0.972500352559583 +DTXSID6021872 Css 3compartmentss Human 95% 0.2987 mg/L 0.8976 mg/L 0.332776292335116 +DTXSID60218962 Css 3compartmentss Human 95% 1.686 mg/L NA NA NA +DTXSID6021907 Css 3compartmentss Human 95% 5.461 mg/L 6.429 mg/L 0.849432260071551 +DTXSID6021909 Css 3compartmentss Human 95% 3.085 mg/L 3.764 mg/L 0.819606801275239 +DTXSID6021953 Css 3compartmentss Human 95% 0.8761 mg/L 0.5927 mg/L 1.47815083516113 +DTXSID6021957 Css 3compartmentss Human 95% 13.33 mg/L 3.923 mg/L 3.39790976293653 +DTXSID6021959 Css 3compartmentss Human 95% 565.9 mg/L 590.6 mg/L 0.958178123941754 +DTXSID6022000 Css 3compartmentss Human 95% 4.671 mg/L 5.288 mg/L 0.883320726172466 +DTXSID6022002 Css 3compartmentss Human 95% 5.453 mg/L 1.35 mg/L 4.03925925925926 +DTXSID6022050 Css 3compartmentss Human 95% 0.786 mg/L NA NA NA +DTXSID6022133 Css 3compartmentss Human 95% 0.4205 mg/L 0.3264 mg/L 1.28829656862745 +DTXSID6022137 Css 3compartmentss Human 95% 0.3001 mg/L 4.313 mg/L 0.0695803385114769 +DTXSID60221794 Css 3compartmentss Human 95% 13.03 mg/L NA NA NA +DTXSID6022187 Css 3compartmentss Human 95% 0.3952 mg/L 0.4057 mg/L 0.974118807000246 +DTXSID6022341 Css 3compartmentss Human 95% 12.7 mg/L 13.22 mg/L 0.960665658093797 +DTXSID6022345 Css 3compartmentss Human 95% 21.67 mg/L 17.53 mg/L 1.23616657159156 +DTXSID6022391 Css 3compartmentss Human 95% 5.649 mg/L 5.877 mg/L 0.961204696273609 +DTXSID6022393 Css 3compartmentss Human 95% 4.358 mg/L 3.774 mg/L 1.15474297827239 +DTXSID6022399 Css 3compartmentss Human 95% 18.6 mg/L 46.43 mg/L 0.400603058367435 +DTXSID6022420 Css 3compartmentss Human 95% 4.98 mg/L 1.285 mg/L 3.87548638132296 +DTXSID6022422 Css 3compartmentss Human 95% 1.981 mg/L 2.042 mg/L 0.970127326150833 +DTXSID6022474 Css 3compartmentss Human 95% 1.632 mg/L 1.675 mg/L 0.974328358208955 +DTXSID6022553 Css 3compartmentss Human 95% 14.02 mg/L 2.848 mg/L 4.92275280898876 +DTXSID6022555 Css 3compartmentss Human 95% 3.521 mg/L 4.654 mg/L 0.756553502363558 +DTXSID6022557 Css 3compartmentss Human 95% 7.588 mg/L 2.573 mg/L 2.94908666925768 +DTXSID6022559 Css 3compartmentss Human 95% 6.71 mg/L 7.679 mg/L 0.87381169423102 +DTXSID6022630 Css 3compartmentss Human 95% 7.279 mg/L 16 mg/L 0.4549375 +DTXSID6022632 Css 3compartmentss Human 95% 0.9544 mg/L 0.7196 mg/L 1.32629238465814 +DTXSID6022636 Css 3compartmentss Human 95% 1.765 mg/L 4.273 mg/L 0.41305874093143 +DTXSID6022638 Css 3compartmentss Human 95% 0.7462 mg/L NA NA NA +DTXSID6022680 Css 3compartmentss Human 95% 2.34 mg/L NA NA NA +DTXSID6022682 Css 3compartmentss Human 95% 1.409 mg/L 2.038 mg/L 0.691364082433759 +DTXSID6022684 Css 3compartmentss Human 95% 6.076 mg/L 4.24 mg/L 1.43301886792453 +DTXSID6022688 Css 3compartmentss Human 95% 0.4011 mg/L 3.415 mg/L 0.117452415812592 +DTXSID6022715 Css 3compartmentss Human 95% 1.175 mg/L 2.627 mg/L 0.447278264179673 +DTXSID6022719 Css 3compartmentss Human 95% 0.6149 mg/L 0.2899 mg/L 2.12107623318386 +DTXSID6022761 Css 3compartmentss Human 95% 4.905 mg/L NA NA NA +DTXSID6022763 Css 3compartmentss Human 95% 0.5752 mg/L NA NA NA +DTXSID6022767 Css 3compartmentss Human 95% 4.553 mg/L NA NA NA +DTXSID6022844 Css 3compartmentss Human 95% 21.69 mg/L 17.24 mg/L 1.25812064965197 +DTXSID6022846 Css 3compartmentss Human 95% 5.38 mg/L 0.3114 mg/L 17.276814386641 +DTXSID6022848 Css 3compartmentss Human 95% 13.18 mg/L NA NA NA +DTXSID6022892 Css 3compartmentss Human 95% 4.121 mg/L 2.17 mg/L 1.89907834101383 +DTXSID6022894 Css 3compartmentss Human 95% 4.881 mg/L 1.644 mg/L 2.96897810218978 +DTXSID6022896 Css 3compartmentss Human 95% 0.2929 mg/L 7.836 mg/L 0.037378764675855 +DTXSID6022898 Css 3compartmentss Human 95% 14.56 mg/L 15.38 mg/L 0.94668400520156 +DTXSID6022923 Css 3compartmentss Human 95% 24.24 mg/L 23.17 mg/L 1.04618040569702 +DTXSID6022927 Css 3compartmentss Human 95% 1.382 mg/L 1.445 mg/L 0.956401384083045 +DTXSID60229659 Css 3compartmentss Human 95% 7.986 mg/L NA NA NA +DTXSID6022973 Css 3compartmentss Human 95% 6.477 mg/L 1.987 mg/L 3.25968797181681 +DTXSID6022975 Css 3compartmentss Human 95% 5.183 mg/L 0.7901 mg/L 6.55992912289584 +DTXSID6022977 Css 3compartmentss Human 95% 4.898 mg/L 5.506 mg/L 0.889575009081002 +DTXSID6023020 Css 3compartmentss Human 95% 1.081 mg/L 0.9838 mg/L 1.09880056922139 +DTXSID6023024 Css 3compartmentss Human 95% 15.07 mg/L 28.96 mg/L 0.520372928176796 +DTXSID6023028 Css 3compartmentss Human 95% 6.377 mg/L 7.415 mg/L 0.860013486176669 +DTXSID6023076 Css 3compartmentss Human 95% 3.299 mg/L 9.023 mg/L 0.365621190291477 +DTXSID6023078 Css 3compartmentss Human 95% 7.425 mg/L 8.563 mg/L 0.867102650940091 +DTXSID60230861 Css 3compartmentss Human 95% 0.9353 mg/L NA NA NA +DTXSID6023101 Css 3compartmentss Human 95% 3.903 mg/L 5.162 mg/L 0.756102285935684 +DTXSID6023103 Css 3compartmentss Human 95% 4.432 mg/L 124.5 mg/L 0.0355983935742972 +DTXSID6023109 Css 3compartmentss Human 95% 0.3765 mg/L 0.2212 mg/L 1.70207956600362 +DTXSID6023153 Css 3compartmentss Human 95% 441.1 mg/L 523.5 mg/L 0.842597898758357 +DTXSID6023155 Css 3compartmentss Human 95% 82.11 mg/L 70.46 mg/L 1.16534203803577 +DTXSID6023157 Css 3compartmentss Human 95% 3.14 mg/L 5.729 mg/L 0.548088671670449 +DTXSID6023159 Css 3compartmentss Human 95% 259.2 mg/L 299.7 mg/L 0.864864864864865 +DTXSID6023232 Css 3compartmentss Human 95% 4.324 mg/L 4.814 mg/L 0.898213543830494 +DTXSID6023280 Css 3compartmentss Human 95% 7.059 mg/L 2.791 mg/L 2.52920100322465 +DTXSID6023284 Css 3compartmentss Human 95% 0.999 mg/L NA NA NA +DTXSID6023286 Css 3compartmentss Human 95% 7.068 mg/L 0.0466 mg/L 151.673819742489 +DTXSID6023313 Css 3compartmentss Human 95% 1.796 mg/L 2.673 mg/L 0.671904227459783 +DTXSID6023315 Css 3compartmentss Human 95% 7.684 mg/L 5.537 mg/L 1.38775510204082 +DTXSID6023317 Css 3compartmentss Human 95% 10.77 mg/L 10.09 mg/L 1.06739345887017 +DTXSID6023319 Css 3compartmentss Human 95% 18.99 mg/L 6.058 mg/L 3.13469792010565 +DTXSID6023363 Css 3compartmentss Human 95% 0.22 mg/L 0.2705 mg/L 0.813308687615527 +DTXSID6023365 Css 3compartmentss Human 95% 2.241 mg/L 0.1246 mg/L 17.9855537720706 +DTXSID6023367 Css 3compartmentss Human 95% 8.467 mg/L 2.247 mg/L 3.76813529149978 +DTXSID6023369 Css 3compartmentss Human 95% 5.487 mg/L 5.671 mg/L 0.967554223241051 +DTXSID60233938 Css 3compartmentss Human 95% 2.993 mg/L NA NA NA +DTXSID6023440 Css 3compartmentss Human 95% 4.634 mg/L 9.34 mg/L 0.496145610278373 +DTXSID6023442 Css 3compartmentss Human 95% 0.3826 mg/L 3.547 mg/L 0.10786580208627 +DTXSID6023446 Css 3compartmentss Human 95% 11.01 mg/L NA NA NA +DTXSID6023448 Css 3compartmentss Human 95% 1.47 mg/L NA NA NA +DTXSID6023490 Css 3compartmentss Human 95% 8.721 mg/L 10.44 mg/L 0.835344827586207 +DTXSID6023492 Css 3compartmentss Human 95% 54.15 mg/L 64.09 mg/L 0.844905601497894 +DTXSID6023496 Css 3compartmentss Human 95% 5.159 mg/L 0.5101 mg/L 10.1137031954519 +DTXSID6023498 Css 3compartmentss Human 95% 2.263 mg/L 1.231 mg/L 1.83834281072299 +DTXSID6023523 Css 3compartmentss Human 95% 1.621 mg/L 2.59 mg/L 0.625868725868726 +DTXSID6023525 Css 3compartmentss Human 95% 0.375 mg/L 0.4662 mg/L 0.804375804375804 +DTXSID6023529 Css 3compartmentss Human 95% 0.4137 mg/L 2.927 mg/L 0.141339255210113 +DTXSID6023571 Css 3compartmentss Human 95% 1.627 mg/L 0.9974 mg/L 1.6312412271907 +DTXSID6023573 Css 3compartmentss Human 95% 0.3193 mg/L 0.4202 mg/L 0.759876249405045 +DTXSID6023577 Css 3compartmentss Human 95% 7.635 mg/L NA NA NA +DTXSID6023579 Css 3compartmentss Human 95% 7.39 mg/L 6.62 mg/L 1.11631419939577 +DTXSID6023600 Css 3compartmentss Human 95% 1.776 mg/L 1.702 mg/L 1.04347826086957 +DTXSID6023602 Css 3compartmentss Human 95% 7.245 mg/L 8.723 mg/L 0.830562879743208 +DTXSID6023604 Css 3compartmentss Human 95% 5.008 mg/L NA NA NA +DTXSID6023606 Css 3compartmentss Human 95% 1.381 mg/L 5.32 mg/L 0.259586466165414 +DTXSID6023608 Css 3compartmentss Human 95% 1.966 mg/L 4.634 mg/L 0.424255502805352 +DTXSID6023650 Css 3compartmentss Human 95% 7.31 mg/L 0.09629 mg/L 75.9165022328383 +DTXSID6023652 Css 3compartmentss Human 95% 0.3197 mg/L 0.613 mg/L 0.521533442088091 +DTXSID6023656 Css 3compartmentss Human 95% 325.9 mg/L 450.2 mg/L 0.723900488671701 +DTXSID6023658 Css 3compartmentss Human 95% 1.954 mg/L 2.041 mg/L 0.957373836354728 +DTXSID60236686 Css 3compartmentss Human 95% 0.3926 mg/L NA NA NA +DTXSID6023733 Css 3compartmentss Human 95% 5.584 mg/L 6.33 mg/L 0.882148499210111 +DTXSID6023735 Css 3compartmentss Human 95% 7.578 mg/L 12.33 mg/L 0.614598540145985 +DTXSID6023737 Css 3compartmentss Human 95% 1.431 mg/L 0.144 mg/L 9.9375 +DTXSID6023739 Css 3compartmentss Human 95% 2.803 mg/L NA NA NA +DTXSID60237739 Css 3compartmentss Human 95% 23.56 mg/L NA NA NA +DTXSID60238246 Css 3compartmentss Human 95% 4.444 mg/L NA NA NA +DTXSID6023862 Css 3compartmentss Human 95% 2.354 mg/L 2.432 mg/L 0.967927631578947 +DTXSID6023864 Css 3compartmentss Human 95% 13.23 mg/L 15.23 mg/L 0.868680236375575 +DTXSID6023868 Css 3compartmentss Human 95% 201 mg/L 2670 mg/L 0.0752808988764045 +DTXSID60239435 Css 3compartmentss Human 95% 4.863 mg/L NA NA NA +DTXSID6023997 Css 3compartmentss Human 95% 11.5 mg/L 2.766 mg/L 4.15762834417932 +DTXSID6023999 Css 3compartmentss Human 95% 5116 mg/L 4.791 mg/L 1067.8355249426 +DTXSID6024046 Css 3compartmentss Human 95% 4.196 mg/L 4.34 mg/L 0.966820276497696 +DTXSID6024048 Css 3compartmentss Human 95% 5.513 mg/L NA NA NA +DTXSID60240824 Css 3compartmentss Human 95% 7.552 mg/L NA NA NA +DTXSID6024123 Css 3compartmentss Human 95% 0.6696 mg/L 0.6779 mg/L 0.987756306239858 +DTXSID6024175 Css 3compartmentss Human 95% 6.844 mg/L 7.007 mg/L 0.97673754816612 +DTXSID6024200 Css 3compartmentss Human 95% 0.3145 mg/L 0.7526 mg/L 0.417884666489503 +DTXSID6024204 Css 3compartmentss Human 95% 2.973 mg/L 3.156 mg/L 0.942015209125475 +DTXSID6024206 Css 3compartmentss Human 95% 64.83 mg/L 67.24 mg/L 0.964158239143367 +DTXSID6024331 Css 3compartmentss Human 95% 8.56 mg/L 9.805 mg/L 0.87302396736359 +DTXSID6024337 Css 3compartmentss Human 95% 53.61 mg/L 52.86 mg/L 1.01418842224745 +DTXSID6024412 Css 3compartmentss Human 95% 0.5054 mg/L 2.122 mg/L 0.238171536286522 +DTXSID6024414 Css 3compartmentss Human 95% 0.5332 mg/L 2.465 mg/L 0.21630831643002 +DTXSID6024460 Css 3compartmentss Human 95% 20.02 mg/L 20.52 mg/L 0.975633528265107 +DTXSID6024462 Css 3compartmentss Human 95% 8.711 mg/L 8.024 mg/L 1.08561814556331 +DTXSID6024466 Css 3compartmentss Human 95% 2.494 mg/L 2.544 mg/L 0.980345911949686 +DTXSID6024591 Css 3compartmentss Human 95% 9.829 mg/L 1.047 mg/L 9.38777459407832 +DTXSID6024597 Css 3compartmentss Human 95% 12.85 mg/L 9.189 mg/L 1.39841114375884 +DTXSID6024624 Css 3compartmentss Human 95% 5.178 mg/L 10.88 mg/L 0.475919117647059 +DTXSID6024628 Css 3compartmentss Human 95% 5.235 mg/L 5.712 mg/L 0.916491596638656 +DTXSID6024670 Css 3compartmentss Human 95% 7.444 mg/L 5.438 mg/L 1.36888561971313 +DTXSID6024674 Css 3compartmentss Human 95% 0.3912 mg/L 0.1022 mg/L 3.82778864970646 +DTXSID6024832 Css 3compartmentss Human 95% 13.51 mg/L 47.92 mg/L 0.281928213689482 +DTXSID6024834 Css 3compartmentss Human 95% 0.7411 mg/L NA NA NA +DTXSID6024838 Css 3compartmentss Human 95% 13.48 mg/L 2.918 mg/L 4.61960246744345 +DTXSID6024882 Css 3compartmentss Human 95% 2.329 mg/L 2.453 mg/L 0.949449653485528 +DTXSID6024888 Css 3compartmentss Human 95% 2.519 mg/L 2.626 mg/L 0.959253617669459 +DTXSID6024917 Css 3compartmentss Human 95% 2.77 mg/L 3.076 mg/L 0.900520156046814 +DTXSID6024967 Css 3compartmentss Human 95% 2.621 mg/L 9.492 mg/L 0.276127265065318 +DTXSID6025010 Css 3compartmentss Human 95% 5.065 mg/L 6.115 mg/L 0.828291087489779 +DTXSID6025018 Css 3compartmentss Human 95% 0.2961 mg/L 0.3776 mg/L 0.78416313559322 +DTXSID6025064 Css 3compartmentss Human 95% 0.5238 mg/L 0.9393 mg/L 0.557649313318429 +DTXSID6025141 Css 3compartmentss Human 95% 4.571 mg/L 5.569 mg/L 0.820793679296103 +DTXSID6025143 Css 3compartmentss Human 95% 0.5239 mg/L 0.3458 mg/L 1.51503759398496 +DTXSID6025145 Css 3compartmentss Human 95% 0.4855 mg/L 0.3791 mg/L 1.28066473226062 +DTXSID6025149 Css 3compartmentss Human 95% 7.856 mg/L 0.2927 mg/L 26.8397676802187 +DTXSID6025226 Css 3compartmentss Human 95% 72.64 mg/L 59.76 mg/L 1.21552878179384 +DTXSID6025272 Css 3compartmentss Human 95% 1.181 mg/L 0.9242 mg/L 1.27786193464618 +DTXSID6025276 Css 3compartmentss Human 95% 6.141 mg/L NA NA NA +DTXSID6025278 Css 3compartmentss Human 95% 0.3314 mg/L 0.3853 mg/L 0.860109005969374 +DTXSID6025301 Css 3compartmentss Human 95% 3.48 mg/L NA NA NA +DTXSID6025303 Css 3compartmentss Human 95% 1.47 mg/L NA NA NA +DTXSID6025305 Css 3compartmentss Human 95% 0.2335 mg/L 5.38 mg/L 0.0434014869888476 +DTXSID6025309 Css 3compartmentss Human 95% 5.689 mg/L NA NA NA +DTXSID6025355 Css 3compartmentss Human 95% 5.856 mg/L 0.7756 mg/L 7.55028365136668 +DTXSID6025432 Css 3compartmentss Human 95% 5.494 mg/L 6.151 mg/L 0.893188099496017 +DTXSID6025436 Css 3compartmentss Human 95% 7.457 mg/L 1.631 mg/L 4.57204169221337 +DTXSID6025438 Css 3compartmentss Human 95% 802.7 mg/L 933 mg/L 0.860342979635584 +DTXSID6025486 Css 3compartmentss Human 95% 2.819 mg/L 3.523 mg/L 0.800170309395402 +DTXSID6025513 Css 3compartmentss Human 95% 1.604 mg/L 0.3761 mg/L 4.26482318532305 +DTXSID6025565 Css 3compartmentss Human 95% 0.3567 mg/L 0.6917 mg/L 0.515685991036577 +DTXSID6025567 Css 3compartmentss Human 95% 0.05463 mg/L 0.05779 mg/L 0.945319259387437 +DTXSID6025569 Css 3compartmentss Human 95% 1.414 mg/L 3.077 mg/L 0.459538511537212 +DTXSID6025640 Css 3compartmentss Human 95% 12.38 mg/L 13.13 mg/L 0.942878903274943 +DTXSID6025642 Css 3compartmentss Human 95% 2.189 mg/L 14.05 mg/L 0.155800711743772 +DTXSID6025690 Css 3compartmentss Human 95% 17.38 mg/L 5.942 mg/L 2.92494109727365 +DTXSID6025696 Css 3compartmentss Human 95% 0.4711 mg/L 2.479 mg/L 0.190036304961678 +DTXSID6025723 Css 3compartmentss Human 95% 0.6311 mg/L 2.704 mg/L 0.233394970414201 +DTXSID6025725 Css 3compartmentss Human 95% 0.71 mg/L 1.664 mg/L 0.426682692307692 +DTXSID6025775 Css 3compartmentss Human 95% 17.51 mg/L 8.928 mg/L 1.96124551971326 +DTXSID6025939 Css 3compartmentss Human 95% 2.329 mg/L 4.525 mg/L 0.514696132596685 +DTXSID6025983 Css 3compartmentss Human 95% 0.3607 mg/L 3.883 mg/L 0.0928920937419521 +DTXSID6026080 Css 3compartmentss Human 95% 22.69 mg/L 23.67 mg/L 0.958597380650613 +DTXSID6026084 Css 3compartmentss Human 95% 85.12 mg/L NA NA NA +DTXSID6026115 Css 3compartmentss Human 95% 0.3117 mg/L 0.3119 mg/L 0.999358768836165 +DTXSID6026161 Css 3compartmentss Human 95% 1.787 mg/L 27.88 mg/L 0.0640961262553802 +DTXSID6026167 Css 3compartmentss Human 95% 0.589 mg/L NA NA NA +DTXSID6026169 Css 3compartmentss Human 95% 0.5452 mg/L NA NA NA +DTXSID6026240 Css 3compartmentss Human 95% 16.77 mg/L NA NA NA +DTXSID6026294 Css 3compartmentss Human 95% 0.1634 mg/L 0.06558 mg/L 2.49161329673681 +DTXSID6026325 Css 3compartmentss Human 95% 0.3415 mg/L 0.6909 mg/L 0.494282819510783 +DTXSID6026373 Css 3compartmentss Human 95% 8.591 mg/L 9.805 mg/L 0.876185619581846 +DTXSID6026535 Css 3compartmentss Human 95% 7.419 mg/L 8.639 mg/L 0.858779951383262 +DTXSID6026537 Css 3compartmentss Human 95% 5.255 mg/L 6.477 mg/L 0.811332406978539 +DTXSID6026799 Css 3compartmentss Human 95% 5.159 mg/L 6.029 mg/L 0.855697462265716 +DTXSID6026878 Css 3compartmentss Human 95% 0.7543 mg/L 0.8473 mg/L 0.890239584562729 +DTXSID6026905 Css 3compartmentss Human 95% 6.248 mg/L NA NA NA +DTXSID6026955 Css 3compartmentss Human 95% 8.174 mg/L 6.802 mg/L 1.20170538077036 +DTXSID6027050 Css 3compartmentss Human 95% 6.118 mg/L 7.282 mg/L 0.840153803900027 +DTXSID6027131 Css 3compartmentss Human 95% 1.779 mg/L 2.342 mg/L 0.759607173356106 +DTXSID6027133 Css 3compartmentss Human 95% 6.706 mg/L 0.5852 mg/L 11.4593301435407 +DTXSID6027137 Css 3compartmentss Human 95% 5.346 mg/L 3788 mg/L 0.00141129883843717 +DTXSID6027214 Css 3compartmentss Human 95% 6.532 mg/L 7.701 mg/L 0.848201532268537 +DTXSID6027218 Css 3compartmentss Human 95% 3.371 mg/L 3.454 mg/L 0.975969889982629 +DTXSID6027262 Css 3compartmentss Human 95% 1.094 mg/L 1.233 mg/L 0.887266828872668 +DTXSID6027341 Css 3compartmentss Human 95% 1.834 mg/L 2.101 mg/L 0.872917658257972 +DTXSID6027343 Css 3compartmentss Human 95% 3.083 mg/L NA NA NA +DTXSID6027345 Css 3compartmentss Human 95% 14.24 mg/L 16.21 mg/L 0.878470080197409 +DTXSID6027397 Css 3compartmentss Human 95% 16.37 mg/L 1013 mg/L 0.0161599210266535 +DTXSID6027503 Css 3compartmentss Human 95% 6.747 mg/L 0.971 mg/L 6.94850669412976 +DTXSID6027507 Css 3compartmentss Human 95% 1.992 mg/L 0.2322 mg/L 8.57881136950904 +DTXSID6027509 Css 3compartmentss Human 95% 0.3417 mg/L 5.697 mg/L 0.0599789362822538 +DTXSID6027551 Css 3compartmentss Human 95% 1.849 mg/L 7.621 mg/L 0.242619078861042 +DTXSID60278061 Css 3compartmentss Human 95% 0.4127 mg/L NA NA NA +DTXSID60278268 Css 3compartmentss Human 95% 0.2948 mg/L NA NA NA +DTXSID6028028 Css 3compartmentss Human 95% 5.763 mg/L 1.662 mg/L 3.46750902527076 +DTXSID60281151 Css 3compartmentss Human 95% 0.8747 mg/L NA NA NA +DTXSID6029121 Css 3compartmentss Human 95% 20.49 mg/L 8.089 mg/L 2.5330696006923 +DTXSID6029123 Css 3compartmentss Human 95% 7.333 mg/L NA NA NA +DTXSID6029127 Css 3compartmentss Human 95% 0.2318 mg/L 3.361 mg/L 0.0689675691758405 +DTXSID6029202 Css 3compartmentss Human 95% 13.64 mg/L 0.09138 mg/L 149.26679798643 +DTXSID6029254 Css 3compartmentss Human 95% 0.6252 mg/L 15.2 mg/L 0.0411315789473684 +DTXSID6029626 Css 3compartmentss Human 95% 9.766 mg/L 11.04 mg/L 0.884601449275362 +DTXSID6029670 Css 3compartmentss Human 95% 0.2679 mg/L 0.4554 mg/L 0.588274044795784 +DTXSID60310238 Css 3compartmentss Human 95% 0.4767 mg/L NA NA NA +DTXSID60311265 Css 3compartmentss Human 95% 0.6851 mg/L NA NA NA +DTXSID6031380 Css 3compartmentss Human 95% 1.167 mg/L 2.119 mg/L 0.550731477111845 +DTXSID6032192 Css 3compartmentss Human 95% 16.1 mg/L 5.454 mg/L 2.95196186285295 +DTXSID6032352 Css 3compartmentss Human 95% 11.37 mg/L 12.92 mg/L 0.880030959752322 +DTXSID6032354 Css 3compartmentss Human 95% 0.275 mg/L 0.2734 mg/L 1.00585223116313 +DTXSID6032356 Css 3compartmentss Human 95% 6.777 mg/L 3.022 mg/L 2.24255459960291 +DTXSID6032358 Css 3compartmentss Human 95% 0.3966 mg/L 0.408 mg/L 0.972058823529412 +DTXSID6032431 Css 3compartmentss Human 95% 1.614 mg/L 5.979 mg/L 0.269944806823884 +DTXSID6032514 Css 3compartmentss Human 95% 0.5103 mg/L 1.09 mg/L 0.468165137614679 +DTXSID6032516 Css 3compartmentss Human 95% 3.545 mg/L 1.591 mg/L 2.22815839094909 +DTXSID6032518 Css 3compartmentss Human 95% 11.88 mg/L NA NA NA +DTXSID6032562 Css 3compartmentss Human 95% 212.2 mg/L 113.1 mg/L 1.8762157382847 +DTXSID6032641 Css 3compartmentss Human 95% 222.1 mg/L 242 mg/L 0.917768595041322 +DTXSID6032645 Css 3compartmentss Human 95% 0.6872 mg/L 0.6994 mg/L 0.982556476980269 +DTXSID6032647 Css 3compartmentss Human 95% 0.8038 mg/L 0.8044 mg/L 0.999254102436599 +DTXSID6032649 Css 3compartmentss Human 95% 9.624 mg/L 7.201 mg/L 1.3364810442994 +DTXSID6032722 Css 3compartmentss Human 95% 1.868 mg/L 2.342 mg/L 0.797608881298036 +DTXSID6033241 Css 3compartmentss Human 95% 0.6789 mg/L NA NA NA +DTXSID6033247 Css 3compartmentss Human 95% 1.148 mg/L 2.299 mg/L 0.499347542409743 +DTXSID6033401 Css 3compartmentss Human 95% 3.929 mg/L 13.87 mg/L 0.283273251622206 +DTXSID6033538 Css 3compartmentss Human 95% 4.288 mg/L 13.42 mg/L 0.319523099850969 +DTXSID60337884 Css 3compartmentss Human 95% 5.274 mg/L NA NA NA +DTXSID6033825 Css 3compartmentss Human 95% 6.792 mg/L 0.6154 mg/L 11.036724081898 +DTXSID6034186 Css 3compartmentss Human 95% 11.3 mg/L 1.964 mg/L 5.75356415478615 +DTXSID6034265 Css 3compartmentss Human 95% 4.212 mg/L 4.258 mg/L 0.989196806012212 +DTXSID6034392 Css 3compartmentss Human 95% 8.192 mg/L 10.12 mg/L 0.809486166007905 +DTXSID6034554 Css 3compartmentss Human 95% 0.2995 mg/L NA NA NA +DTXSID6034712 Css 3compartmentss Human 95% 0.1292 mg/L NA NA NA +DTXSID6034764 Css 3compartmentss Human 95% 9.93 mg/L 6.059 mg/L 1.63888430434065 +DTXSID6034849 Css 3compartmentss Human 95% 0.6925 mg/L 0.8238 mg/L 0.840616654527798 +DTXSID6034924 Css 3compartmentss Human 95% 8.693 mg/L 10.35 mg/L 0.839903381642512 +DTXSID6034928 Css 3compartmentss Human 95% 4.087 mg/L 9.542 mg/L 0.428316914692936 +DTXSID6034972 Css 3compartmentss Human 95% 3.337 mg/L 3.26 mg/L 1.02361963190184 +DTXSID6035106 Css 3compartmentss Human 95% 5.077 mg/L 5.581 mg/L 0.9096936032969 +DTXSID6035156 Css 3compartmentss Human 95% 1.988 mg/L NA NA NA +DTXSID6036467 Css 3compartmentss Human 95% 2.059 mg/L 9.529 mg/L 0.216077237905342 +DTXSID6037069 Css 3compartmentss Human 95% 32.39 mg/L 37.6 mg/L 0.861436170212766 +DTXSID6037483 Css 3compartmentss Human 95% 0.8766 mg/L 1.504 mg/L 0.582845744680851 +DTXSID6037564 Css 3compartmentss Human 95% 11.6 mg/L 9.748 mg/L 1.18998768978252 +DTXSID6037568 Css 3compartmentss Human 95% 0.5065 mg/L 23.57 mg/L 0.0214891811624947 +DTXSID6037649 Css 3compartmentss Human 95% 4.177 mg/L 8.97 mg/L 0.465663322185061 +DTXSID6037697 Css 3compartmentss Human 95% 0.4722 mg/L 1.534 mg/L 0.307822685788787 +DTXSID6037728 Css 3compartmentss Human 95% 1.942 mg/L 1.901 mg/L 1.0215675960021 +DTXSID6038798 Css 3compartmentss Human 95% 0.8149 mg/L NA NA NA +DTXSID6038827 Css 3compartmentss Human 95% 2.377 mg/L 1.56 mg/L 1.52371794871795 +DTXSID6038875 Css 3compartmentss Human 95% 3.604 mg/L 1.62 mg/L 2.22469135802469 +DTXSID6038877 Css 3compartmentss Human 95% 9.91 mg/L 6.368 mg/L 1.55621859296482 +DTXSID6040115 Css 3compartmentss Human 95% 7.23 mg/L 8.738 mg/L 0.827420462348364 +DTXSID6040246 Css 3compartmentss Human 95% 20.52 mg/L 221.4 mg/L 0.0926829268292683 +DTXSID6040290 Css 3compartmentss Human 95% 2.697 mg/L 0.8497 mg/L 3.1740614334471 +DTXSID6040296 Css 3compartmentss Human 95% 80.31 mg/L 118.6 mg/L 0.677150084317032 +DTXSID6040371 Css 3compartmentss Human 95% 1.113 mg/L 12.85 mg/L 0.0866147859922179 +DTXSID6040373 Css 3compartmentss Human 95% 21.88 mg/L 15.23 mg/L 1.43663821405121 +DTXSID6040375 Css 3compartmentss Human 95% 7.331 mg/L 4.867 mg/L 1.50626669406205 +DTXSID6040404 Css 3compartmentss Human 95% 18.52 mg/L NA NA NA +DTXSID6040531 Css 3compartmentss Human 95% 6.272 mg/L NA NA NA +DTXSID6040537 Css 3compartmentss Human 95% 0.4105 mg/L NA NA NA +DTXSID6040583 Css 3compartmentss Human 95% 0.5532 mg/L 3.625 mg/L 0.152606896551724 +DTXSID6040614 Css 3compartmentss Human 95% 6.418 mg/L 7.522 mg/L 0.853230523796862 +DTXSID6040618 Css 3compartmentss Human 95% 71.63 mg/L NA NA NA +DTXSID6040662 Css 3compartmentss Human 95% 3.894 mg/L 14.61 mg/L 0.26652977412731 +DTXSID6040664 Css 3compartmentss Human 95% 1.372 mg/L 2.353 mg/L 0.583085422864428 +DTXSID6040666 Css 3compartmentss Human 95% 6.158 mg/L 2.838 mg/L 2.16983791402396 +DTXSID6040668 Css 3compartmentss Human 95% 25.66 mg/L 3.594 mg/L 7.13967723984419 +DTXSID60406887 Css 3compartmentss Human 95% 0.5264 mg/L NA NA NA +DTXSID6040743 Css 3compartmentss Human 95% 14.2 mg/L 77.59 mg/L 0.18301327490656 +DTXSID6040745 Css 3compartmentss Human 95% 59.61 mg/L 2.969 mg/L 20.0774671606602 +DTXSID6040747 Css 3compartmentss Human 95% 2.413 mg/L 5.779 mg/L 0.41754628828517 +DTXSID6040795 Css 3compartmentss Human 95% 1.775 mg/L 49.88 mg/L 0.0355854049719326 +DTXSID6040799 Css 3compartmentss Human 95% 19.84 mg/L NA NA NA +DTXSID6041056 Css 3compartmentss Human 95% 4.835 mg/L 5.182 mg/L 0.933037437282902 +DTXSID6041133 Css 3compartmentss Human 95% 1.661 mg/L 28.06 mg/L 0.0591945830363507 +DTXSID6041268 Css 3compartmentss Human 95% 8.779 mg/L NA NA NA +DTXSID6041347 Css 3compartmentss Human 95% 10.45 mg/L 1.314 mg/L 7.95281582952816 +DTXSID6041349 Css 3compartmentss Human 95% 2.498 mg/L 0.4286 mg/L 5.82827811479235 +DTXSID6041397 Css 3compartmentss Human 95% 4.919 mg/L NA NA NA +DTXSID6041420 Css 3compartmentss Human 95% 0.3034 mg/L 7.983 mg/L 0.0380057622447701 +DTXSID6041422 Css 3compartmentss Human 95% 9.896 mg/L 3.087 mg/L 3.20570132815031 +DTXSID6041472 Css 3compartmentss Human 95% 0.3688 mg/L 0.6211 mg/L 0.593785219771373 +DTXSID6041503 Css 3compartmentss Human 95% 11.77 mg/L 1664 mg/L 0.00707331730769231 +DTXSID6041551 Css 3compartmentss Human 95% 11.19 mg/L 5.793 mg/L 1.93164163645779 +DTXSID6041636 Css 3compartmentss Human 95% 0.8488 mg/L NA NA NA +DTXSID6041638 Css 3compartmentss Human 95% 0.4598 mg/L 1.401 mg/L 0.32819414703783 +DTXSID6041682 Css 3compartmentss Human 95% 461.2 mg/L 2363 mg/L 0.195175624206517 +DTXSID6041684 Css 3compartmentss Human 95% 19.69 mg/L 8.431 mg/L 2.33542877475982 +DTXSID6041688 Css 3compartmentss Human 95% 1.804 mg/L 5.958 mg/L 0.302786169855656 +DTXSID6041715 Css 3compartmentss Human 95% 37.53 mg/L 240.3 mg/L 0.156179775280899 +DTXSID6041719 Css 3compartmentss Human 95% 5.761 mg/L 86.35 mg/L 0.0667168500289519 +DTXSID6041844 Css 3compartmentss Human 95% 5.072 mg/L 5.576 mg/L 0.90961262553802 +DTXSID6041892 Css 3compartmentss Human 95% 2.942 mg/L 6.71 mg/L 0.438450074515648 +DTXSID6041925 Css 3compartmentss Human 95% 0.4563 mg/L 0.5228 mg/L 0.872800306044376 +DTXSID6041927 Css 3compartmentss Human 95% 0.6394 mg/L 4.477 mg/L 0.142818851909761 +DTXSID6041973 Css 3compartmentss Human 95% 15.44 mg/L NA NA NA +DTXSID6041977 Css 3compartmentss Human 95% 11.05 mg/L 23.58 mg/L 0.468617472434266 +DTXSID6042072 Css 3compartmentss Human 95% 0.5203 mg/L 0.3588 mg/L 1.45011148272018 +DTXSID6042074 Css 3compartmentss Human 95% 4.828 mg/L 3.984 mg/L 1.21184738955823 +DTXSID6042151 Css 3compartmentss Human 95% 1.919 mg/L 0.2216 mg/L 8.65974729241877 +DTXSID6042157 Css 3compartmentss Human 95% 1.367 mg/L 3.711 mg/L 0.368364322285098 +DTXSID6042232 Css 3compartmentss Human 95% 0.3695 mg/L 1.517 mg/L 0.243572841133817 +DTXSID6042234 Css 3compartmentss Human 95% 6.567 mg/L 8.909 mg/L 0.73711976652823 +DTXSID6042280 Css 3compartmentss Human 95% 1.862 mg/L 6.418 mg/L 0.290121533187909 +DTXSID6042282 Css 3compartmentss Human 95% 0.6672 mg/L 2.551 mg/L 0.261544492355939 +DTXSID6042315 Css 3compartmentss Human 95% 6.644 mg/L 4.363 mg/L 1.52280540912216 +DTXSID6042365 Css 3compartmentss Human 95% 7.389 mg/L 6.532 mg/L 1.13120024494795 +DTXSID6042369 Css 3compartmentss Human 95% 9.059 mg/L 0.5125 mg/L 17.6760975609756 +DTXSID6042440 Css 3compartmentss Human 95% 15.59 mg/L 40.63 mg/L 0.383706620723603 +DTXSID6042448 Css 3compartmentss Human 95% 0.8376 mg/L 0.6936 mg/L 1.2076124567474 +DTXSID6042521 Css 3compartmentss Human 95% 0.6103 mg/L 3.429 mg/L 0.177981918926801 +DTXSID6042579 Css 3compartmentss Human 95% 7.199 mg/L 1.582 mg/L 4.55056890012642 +DTXSID6042602 Css 3compartmentss Human 95% 1.658 mg/L 0.3789 mg/L 4.37582475587226 +DTXSID60432080 Css 3compartmentss Human 95% 8.668 mg/L NA NA NA +DTXSID6043709 Css 3compartmentss Human 95% 0.8227 mg/L 0.1263 mg/L 6.513855898654 +DTXSID6043913 Css 3compartmentss Human 95% 2.338 mg/L 0.3669 mg/L 6.37230853093486 +DTXSID6043915 Css 3compartmentss Human 95% 2.172 mg/L 2.201 mg/L 0.98682417083144 +DTXSID6043917 Css 3compartmentss Human 95% 5.195 mg/L 5.642 mg/L 0.920772775611485 +DTXSID6043919 Css 3compartmentss Human 95% 5.069 mg/L 5.575 mg/L 0.909237668161435 +DTXSID6044012 Css 3compartmentss Human 95% 413.4 mg/L 433.2 mg/L 0.954293628808864 +DTXSID6044014 Css 3compartmentss Human 95% 0.7648 mg/L 1.673 mg/L 0.457142857142857 +DTXSID6044018 Css 3compartmentss Human 95% 4.702 mg/L NA NA NA +DTXSID6044199 Css 3compartmentss Human 95% 0.01401 mg/L 0.004682 mg/L 2.99231097821444 +DTXSID6044226 Css 3compartmentss Human 95% 14.48 mg/L 36.12 mg/L 0.400885935769657 +DTXSID6044272 Css 3compartmentss Human 95% 0.707 mg/L 35.77 mg/L 0.0197651663405088 +DTXSID6044278 Css 3compartmentss Human 95% 2.56 mg/L NA NA NA +DTXSID6044303 Css 3compartmentss Human 95% 13.26 mg/L 224.3 mg/L 0.0591172536781097 +DTXSID6044305 Css 3compartmentss Human 95% 0.7843 mg/L NA NA NA +DTXSID6044307 Css 3compartmentss Human 95% 1.456 mg/L 5.271 mg/L 0.276228419654714 +DTXSID6044309 Css 3compartmentss Human 95% 3.063 mg/L NA NA NA +DTXSID6044353 Css 3compartmentss Human 95% 0.8075 mg/L NA NA NA +DTXSID6044355 Css 3compartmentss Human 95% 0.4703 mg/L 0.5196 mg/L 0.905119322555812 +DTXSID6044357 Css 3compartmentss Human 95% 0.04724 mg/L 0.04844 mg/L 0.975227085053675 +DTXSID6044359 Css 3compartmentss Human 95% 20.92 mg/L 23.96 mg/L 0.873121869782972 +DTXSID6044430 Css 3compartmentss Human 95% 7.355 mg/L 8.098 mg/L 0.908248950358113 +DTXSID6044436 Css 3compartmentss Human 95% 7.08 mg/L 8.46 mg/L 0.836879432624113 +DTXSID6044438 Css 3compartmentss Human 95% 5.857 mg/L 5.214 mg/L 1.12332182585347 +DTXSID6044480 Css 3compartmentss Human 95% 5.54 mg/L 2.167 mg/L 2.55652976465159 +DTXSID6044486 Css 3compartmentss Human 95% 0.4376 mg/L 0.5276 mg/L 0.829416224412434 +DTXSID6044488 Css 3compartmentss Human 95% 5.991 mg/L 3.143 mg/L 1.90614062997137 +DTXSID6044511 Css 3compartmentss Human 95% 1.832 mg/L 5.65 mg/L 0.324247787610619 +DTXSID6044513 Css 3compartmentss Human 95% 0.3598 mg/L 0.4767 mg/L 0.754772393538913 +DTXSID6044515 Css 3compartmentss Human 95% 0.383 mg/L 2.065 mg/L 0.18547215496368 +DTXSID6044517 Css 3compartmentss Human 95% 0.466 mg/L 2.008 mg/L 0.23207171314741 +DTXSID6044519 Css 3compartmentss Human 95% 16.01 mg/L 64.35 mg/L 0.248795648795649 +DTXSID6044565 Css 3compartmentss Human 95% 8.236 mg/L 0.1026 mg/L 80.2729044834308 +DTXSID6044642 Css 3compartmentss Human 95% 19.36 mg/L 8.074 mg/L 2.39782016348774 +DTXSID6044644 Css 3compartmentss Human 95% 1.098 mg/L 0.6592 mg/L 1.66565533980583 +DTXSID6044646 Css 3compartmentss Human 95% 2.141 mg/L 0.04836 mg/L 44.2721257237386 +DTXSID6044648 Css 3compartmentss Human 95% 0.8935 mg/L 0.8642 mg/L 1.03390418884517 +DTXSID6044690 Css 3compartmentss Human 95% 16.63 mg/L 1.974 mg/L 8.42451874366768 +DTXSID6044692 Css 3compartmentss Human 95% 1.025 mg/L 0.2997 mg/L 3.42008675342009 +DTXSID6044696 Css 3compartmentss Human 95% 6.879 mg/L 0.07428 mg/L 92.6090468497577 +DTXSID6044721 Css 3compartmentss Human 95% 6.206 mg/L 5.255 mg/L 1.18097050428164 +DTXSID6044725 Css 3compartmentss Human 95% 0.2916 mg/L 5.36 mg/L 0.0544029850746269 +DTXSID6044771 Css 3compartmentss Human 95% 0.3452 mg/L 6.883 mg/L 0.0501525497602789 +DTXSID6044773 Css 3compartmentss Human 95% 2.237 mg/L 6.909 mg/L 0.323780576060211 +DTXSID6044777 Css 3compartmentss Human 95% 7.161 mg/L 0.2835 mg/L 25.2592592592593 +DTXSID6044779 Css 3compartmentss Human 95% 0.4085 mg/L 2.859 mg/L 0.142882126617698 +DTXSID6044800 Css 3compartmentss Human 95% 10.37 mg/L 4.098 mg/L 2.53050268423621 +DTXSID6044802 Css 3compartmentss Human 95% 17.28 mg/L 4.199 mg/L 4.11526553941415 +DTXSID6044804 Css 3compartmentss Human 95% 0.2339 mg/L 5.565 mg/L 0.0420305480682839 +DTXSID6044852 Css 3compartmentss Human 95% 0.7768 mg/L NA NA NA +DTXSID6044854 Css 3compartmentss Human 95% 0.2678 mg/L 3.204 mg/L 0.0835830212234707 +DTXSID6044856 Css 3compartmentss Human 95% 0.7125 mg/L 0.9557 mg/L 0.745526838966203 +DTXSID6044858 Css 3compartmentss Human 95% 0.502 mg/L 25.75 mg/L 0.019495145631068 +DTXSID6044931 Css 3compartmentss Human 95% 5.72 mg/L 0.1956 mg/L 29.2433537832311 +DTXSID6044933 Css 3compartmentss Human 95% 7.484 mg/L 3.715 mg/L 2.01453566621803 +DTXSID6044981 Css 3compartmentss Human 95% 4.272 mg/L 8.027 mg/L 0.532203812134048 +DTXSID6044983 Css 3compartmentss Human 95% 8.84 mg/L 8.726 mg/L 1.01306440522576 +DTXSID6044985 Css 3compartmentss Human 95% 8.563 mg/L 5.006 mg/L 1.71054734318817 +DTXSID6044989 Css 3compartmentss Human 95% 1.689 mg/L 2.065 mg/L 0.817917675544794 +DTXSID6045082 Css 3compartmentss Human 95% 0.2675 mg/L 1.38 mg/L 0.193840579710145 +DTXSID6045084 Css 3compartmentss Human 95% 6.639 mg/L 8.928 mg/L 0.743615591397849 +DTXSID6045086 Css 3compartmentss Human 95% 2.776 mg/L 76.55 mg/L 0.036263879817113 +DTXSID6045088 Css 3compartmentss Human 95% 4.889 mg/L 4.996 mg/L 0.978582866293034 +DTXSID6045115 Css 3compartmentss Human 95% 9.981 mg/L 19.59 mg/L 0.509494640122511 +DTXSID6045117 Css 3compartmentss Human 95% 9.464 mg/L 6.978 mg/L 1.35626253940957 +DTXSID6045119 Css 3compartmentss Human 95% 4.359 mg/L 10.75 mg/L 0.405488372093023 +DTXSID6045161 Css 3compartmentss Human 95% 0.9966 mg/L 0.1113 mg/L 8.95417789757412 +DTXSID6045163 Css 3compartmentss Human 95% 19.16 mg/L 5.896 mg/L 3.24966078697422 +DTXSID6045165 Css 3compartmentss Human 95% 6.919 mg/L 10.59 mg/L 0.653352219074599 +DTXSID6045167 Css 3compartmentss Human 95% 13.98 mg/L 3.205 mg/L 4.3619344773791 +DTXSID6045169 Css 3compartmentss Human 95% 1.195 mg/L 1.635 mg/L 0.730886850152905 +DTXSID6045244 Css 3compartmentss Human 95% 7.366 mg/L 2.464 mg/L 2.98944805194805 +DTXSID6045248 Css 3compartmentss Human 95% 0.8761 mg/L 0.1259 mg/L 6.95869737887212 +DTXSID6045292 Css 3compartmentss Human 95% 2.038 mg/L 1.772 mg/L 1.15011286681716 +DTXSID6045296 Css 3compartmentss Human 95% 7.359 mg/L 0.3854 mg/L 19.094447327452 +DTXSID6045321 Css 3compartmentss Human 95% 0.6181 mg/L 0.1496 mg/L 4.13168449197861 +DTXSID6045323 Css 3compartmentss Human 95% 0.7881 mg/L 2.693 mg/L 0.292647604901597 +DTXSID6045325 Css 3compartmentss Human 95% 0.6999 mg/L 0.2064 mg/L 3.39098837209302 +DTXSID6045371 Css 3compartmentss Human 95% 2.823 mg/L 1.8 mg/L 1.56833333333333 +DTXSID6045373 Css 3compartmentss Human 95% 1.753 mg/L 3.298 mg/L 0.531534263189812 +DTXSID6045375 Css 3compartmentss Human 95% 3.209 mg/L 3.244 mg/L 0.98921085080148 +DTXSID6045377 Css 3compartmentss Human 95% 19.25 mg/L 6.561 mg/L 2.93400396281055 +DTXSID6045400 Css 3compartmentss Human 95% 8.286 mg/L 1.21 mg/L 6.84793388429752 +DTXSID6045402 Css 3compartmentss Human 95% 1.507 mg/L 0.02008 mg/L 75.0498007968127 +DTXSID6045408 Css 3compartmentss Human 95% 157 mg/L NA NA NA +DTXSID6045452 Css 3compartmentss Human 95% 0.9013 mg/L 22.29 mg/L 0.0404351727231943 +DTXSID6045531 Css 3compartmentss Human 95% 7.442 mg/L 0.4091 mg/L 18.1911513077487 +DTXSID6045533 Css 3compartmentss Human 95% 1.638 mg/L 3.811 mg/L 0.429808449225925 +DTXSID6045535 Css 3compartmentss Human 95% 3.163 mg/L 21.06 mg/L 0.150189933523267 +DTXSID6045537 Css 3compartmentss Human 95% 12.73 mg/L 0.4334 mg/L 29.3724042455007 +DTXSID6045539 Css 3compartmentss Human 95% 0.4381 mg/L 1.73 mg/L 0.253236994219653 +DTXSID6045581 Css 3compartmentss Human 95% 0.6705 mg/L 4.76 mg/L 0.140861344537815 +DTXSID6045583 Css 3compartmentss Human 95% 7.927 mg/L 55.57 mg/L 0.142648911283066 +DTXSID6045585 Css 3compartmentss Human 95% 2.101 mg/L 8.116 mg/L 0.258871365204534 +DTXSID6045587 Css 3compartmentss Human 95% 44.83 mg/L NA NA NA +DTXSID6045614 Css 3compartmentss Human 95% 3.026 mg/L 1.774 mg/L 1.70574971815107 +DTXSID6045616 Css 3compartmentss Human 95% 8.294 mg/L 1.927 mg/L 4.30409963674105 +DTXSID6045618 Css 3compartmentss Human 95% 3.032 mg/L 5.925 mg/L 0.511729957805907 +DTXSID6045660 Css 3compartmentss Human 95% 0.3637 mg/L 1.557 mg/L 0.23359023763648 +DTXSID6045662 Css 3compartmentss Human 95% 3.57 mg/L 1.367 mg/L 2.61155815654718 +DTXSID6045666 Css 3compartmentss Human 95% 1.473 mg/L 0.2662 mg/L 5.53343350864012 +DTXSID6045668 Css 3compartmentss Human 95% 2.683 mg/L 3.116 mg/L 0.861039794608472 +DTXSID6045741 Css 3compartmentss Human 95% 1.726 mg/L 53 mg/L 0.0325660377358491 +DTXSID6045743 Css 3compartmentss Human 95% 3.486 mg/L 8.136 mg/L 0.428466076696165 +DTXSID6045745 Css 3compartmentss Human 95% 4.082 mg/L 1.607 mg/L 2.54013690105787 +DTXSID6045749 Css 3compartmentss Human 95% 6.626 mg/L 0.5586 mg/L 11.8617973505192 +DTXSID6045791 Css 3compartmentss Human 95% 0.6847 mg/L 2.423 mg/L 0.282583574081717 +DTXSID6045795 Css 3compartmentss Human 95% 0.5023 mg/L 1.729 mg/L 0.290514748409485 +DTXSID6045820 Css 3compartmentss Human 95% 0.8945 mg/L 16.24 mg/L 0.0550800492610837 +DTXSID6045828 Css 3compartmentss Human 95% 0.7315 mg/L 0.2709 mg/L 2.70025839793282 +DTXSID6045870 Css 3compartmentss Human 95% 6.255 mg/L 3.64 mg/L 1.71840659340659 +DTXSID6045872 Css 3compartmentss Human 95% 0.9155 mg/L 12.96 mg/L 0.0706404320987654 +DTXSID6045874 Css 3compartmentss Human 95% 9.772 mg/L 12.53 mg/L 0.779888268156425 +DTXSID6045878 Css 3compartmentss Human 95% 1.015 mg/L 58.35 mg/L 0.017395029991431 +DTXSID6045901 Css 3compartmentss Human 95% 0.4841 mg/L 0.6847 mg/L 0.707024974441361 +DTXSID6045905 Css 3compartmentss Human 95% 1.309 mg/L 1.618 mg/L 0.80902348578492 +DTXSID6045907 Css 3compartmentss Human 95% 3.692 mg/L 22.3 mg/L 0.165560538116592 +DTXSID6045909 Css 3compartmentss Human 95% 0.4478 mg/L 0.6262 mg/L 0.715106994570425 +DTXSID6045951 Css 3compartmentss Human 95% 0.9507 mg/L 1.941 mg/L 0.489799072642968 +DTXSID6045953 Css 3compartmentss Human 95% 2.294 mg/L 1.695 mg/L 1.35339233038348 +DTXSID6045955 Css 3compartmentss Human 95% 31.08 mg/L 6.379 mg/L 4.8722370277473 +DTXSID6045957 Css 3compartmentss Human 95% 4.239 mg/L 2.132 mg/L 1.98827392120075 +DTXSID6045959 Css 3compartmentss Human 95% 1226 mg/L 2159 mg/L 0.567855488652154 +DTXSID6046000 Css 3compartmentss Human 95% 0.4926 mg/L 0.2442 mg/L 2.01719901719902 +DTXSID6046008 Css 3compartmentss Human 95% 0.5583 mg/L 0.04044 mg/L 13.8056379821958 +DTXSID6046054 Css 3compartmentss Human 95% 0.1691 mg/L 0.03156 mg/L 5.35804816223067 +DTXSID6046131 Css 3compartmentss Human 95% 11.58 mg/L 321.8 mg/L 0.0359850839030454 +DTXSID6046133 Css 3compartmentss Human 95% 8.694 mg/L 97.4 mg/L 0.0892607802874743 +DTXSID6046135 Css 3compartmentss Human 95% 0.3962 mg/L 0.8764 mg/L 0.452076677316294 +DTXSID6046137 Css 3compartmentss Human 95% 2.432 mg/L 0.889 mg/L 2.73565804274466 +DTXSID6046139 Css 3compartmentss Human 95% 0.3031 mg/L 0.05384 mg/L 5.62964338781575 +DTXSID6046181 Css 3compartmentss Human 95% 2.805 mg/L 1.289 mg/L 2.17610550814585 +DTXSID6046183 Css 3compartmentss Human 95% 5.46 mg/L 10.19 mg/L 0.535819430814524 +DTXSID6046185 Css 3compartmentss Human 95% 5.108 mg/L 41.12 mg/L 0.124221789883268 +DTXSID6046187 Css 3compartmentss Human 95% 2.939 mg/L 4.126 mg/L 0.712312166747455 +DTXSID6046189 Css 3compartmentss Human 95% 1.283 mg/L 3.889 mg/L 0.329904859861147 +DTXSID6046210 Css 3compartmentss Human 95% 1.571 mg/L 2.049 mg/L 0.766715470961445 +DTXSID6046212 Css 3compartmentss Human 95% 17.21 mg/L 0.2209 mg/L 77.9085559076505 +DTXSID6046214 Css 3compartmentss Human 95% 2.914 mg/L 5.263 mg/L 0.553676610298309 +DTXSID6046216 Css 3compartmentss Human 95% 3.76 mg/L 266.9 mg/L 0.0140876732858749 +DTXSID6046218 Css 3compartmentss Human 95% 11.21 mg/L 4.757 mg/L 2.35652722303973 +DTXSID6046260 Css 3compartmentss Human 95% 5.028 mg/L 6.196 mg/L 0.811491284699806 +DTXSID6046262 Css 3compartmentss Human 95% 6.472 mg/L 7.646 mg/L 0.846455663091813 +DTXSID6046264 Css 3compartmentss Human 95% 1.537 mg/L 0.395 mg/L 3.89113924050633 +DTXSID6046266 Css 3compartmentss Human 95% 4.248 mg/L 1.422 mg/L 2.9873417721519 +DTXSID6046268 Css 3compartmentss Human 95% 3.682 mg/L 1.628 mg/L 2.26167076167076 +DTXSID6046341 Css 3compartmentss Human 95% 6.482 mg/L 0.07179 mg/L 90.2911268978966 +DTXSID6046343 Css 3compartmentss Human 95% 6.297 mg/L 1.087 mg/L 5.79300827966881 +DTXSID6046345 Css 3compartmentss Human 95% 5.125 mg/L 5.586 mg/L 0.917472252058718 +DTXSID6046347 Css 3compartmentss Human 95% 5.016 mg/L 5.53 mg/L 0.907052441229656 +DTXSID6046349 Css 3compartmentss Human 95% 5.061 mg/L 5.32 mg/L 0.951315789473684 +DTXSID6046391 Css 3compartmentss Human 95% 0.4675 mg/L 4.432 mg/L 0.10548285198556 +DTXSID6046393 Css 3compartmentss Human 95% 5.043 mg/L 6.022 mg/L 0.837429425440053 +DTXSID6046395 Css 3compartmentss Human 95% 1.591 mg/L 13.33 mg/L 0.119354838709677 +DTXSID6046397 Css 3compartmentss Human 95% 6.937 mg/L 7.951 mg/L 0.87246887184002 +DTXSID6046399 Css 3compartmentss Human 95% 0.42 mg/L 5.046 mg/L 0.0832342449464923 +DTXSID6046420 Css 3compartmentss Human 95% 2.132 mg/L 0.4075 mg/L 5.2319018404908 +DTXSID6046422 Css 3compartmentss Human 95% 4.024 mg/L 5.575 mg/L 0.721793721973094 +DTXSID6046424 Css 3compartmentss Human 95% 2.333 mg/L 0.9551 mg/L 2.44267615956444 +DTXSID6046426 Css 3compartmentss Human 95% 0.1002 mg/L 0.03806 mg/L 2.6326852338413 +DTXSID6046428 Css 3compartmentss Human 95% 7.352 mg/L 5.716 mg/L 1.28621413575927 +DTXSID6046470 Css 3compartmentss Human 95% 16.3 mg/L 2.197 mg/L 7.41920801092399 +DTXSID6046472 Css 3compartmentss Human 95% 0.9513 mg/L 0.2404 mg/L 3.95715474209651 +DTXSID6046474 Css 3compartmentss Human 95% 3.099 mg/L 6.943 mg/L 0.446348840558836 +DTXSID6046476 Css 3compartmentss Human 95% 6.847 mg/L 10.28 mg/L 0.666050583657588 +DTXSID6046478 Css 3compartmentss Human 95% 49.31 mg/L 19.99 mg/L 2.46673336668334 +DTXSID6046501 Css 3compartmentss Human 95% 10.05 mg/L 45.76 mg/L 0.219624125874126 +DTXSID6046503 Css 3compartmentss Human 95% 10.19 mg/L 2.396 mg/L 4.25292153589316 +DTXSID6046505 Css 3compartmentss Human 95% 0.8885 mg/L 0.3286 mg/L 2.703895313451 +DTXSID6046507 Css 3compartmentss Human 95% 4.975 mg/L 3.055 mg/L 1.62847790507365 +DTXSID6046509 Css 3compartmentss Human 95% 2.874 mg/L 11.8 mg/L 0.243559322033898 +DTXSID6046551 Css 3compartmentss Human 95% 2.933 mg/L 4.825 mg/L 0.607875647668394 +DTXSID6046553 Css 3compartmentss Human 95% 18.05 mg/L 2.293 mg/L 7.87178368948975 +DTXSID6046555 Css 3compartmentss Human 95% 6.048 mg/L 3.25 mg/L 1.86092307692308 +DTXSID6046557 Css 3compartmentss Human 95% 7.893 mg/L 138 mg/L 0.057195652173913 +DTXSID6046630 Css 3compartmentss Human 95% 17.35 mg/L 218.7 mg/L 0.0793324188385917 +DTXSID6046634 Css 3compartmentss Human 95% 3.118 mg/L 8.241 mg/L 0.378352141730373 +DTXSID6046636 Css 3compartmentss Human 95% 2.542 mg/L 95.17 mg/L 0.0267100977198697 +DTXSID6046638 Css 3compartmentss Human 95% 73.85 mg/L 100.5 mg/L 0.734825870646766 +DTXSID6046682 Css 3compartmentss Human 95% 11.56 mg/L 0.3646 mg/L 31.7059791552386 +DTXSID6046686 Css 3compartmentss Human 95% 248.8 mg/L 245.7 mg/L 1.01261701261701 +DTXSID6046688 Css 3compartmentss Human 95% 4.039 mg/L 7.525 mg/L 0.536744186046512 +DTXSID6046713 Css 3compartmentss Human 95% 6.825 mg/L 4.986 mg/L 1.36883273164862 +DTXSID6046715 Css 3compartmentss Human 95% 5.687 mg/L 2.227 mg/L 2.55365963179165 +DTXSID6046719 Css 3compartmentss Human 95% 2.572 mg/L 9.481 mg/L 0.271279400907077 +DTXSID6046761 Css 3compartmentss Human 95% 0.6842 mg/L 1.095 mg/L 0.624840182648402 +DTXSID6046763 Css 3compartmentss Human 95% 11.71 mg/L 11.93 mg/L 0.981559094719195 +DTXSID6046765 Css 3compartmentss Human 95% 1.113 mg/L 2.506 mg/L 0.444134078212291 +DTXSID6046767 Css 3compartmentss Human 95% 6.192 mg/L 0.6242 mg/L 9.91989746876001 +DTXSID6046842 Css 3compartmentss Human 95% 3.298 mg/L 5.981 mg/L 0.551412807222872 +DTXSID6046844 Css 3compartmentss Human 95% 9.879 mg/L 4.324 mg/L 2.28469010175763 +DTXSID6046846 Css 3compartmentss Human 95% 0.8521 mg/L 0.5382 mg/L 1.58324043106652 +DTXSID6046890 Css 3compartmentss Human 95% 1.329 mg/L 0.02127 mg/L 62.4823695345557 +DTXSID6046892 Css 3compartmentss Human 95% 1.919 mg/L 0.1721 mg/L 11.150493898896 +DTXSID6046896 Css 3compartmentss Human 95% 11.04 mg/L 1.383 mg/L 7.98264642082429 +DTXSID6046898 Css 3compartmentss Human 95% 4.881 mg/L 2.309 mg/L 2.11390212213079 +DTXSID6046925 Css 3compartmentss Human 95% 1.6 mg/L 4.531 mg/L 0.353122930920327 +DTXSID6046977 Css 3compartmentss Human 95% 1.016 mg/L 0.2544 mg/L 3.9937106918239 +DTXSID6046979 Css 3compartmentss Human 95% 18.92 mg/L 24.33 mg/L 0.77764077270859 +DTXSID6047028 Css 3compartmentss Human 95% 3.023 mg/L 3.501 mg/L 0.863467580691231 +DTXSID6047070 Css 3compartmentss Human 95% 0.3617 mg/L 7.982 mg/L 0.0453144575294412 +DTXSID6047072 Css 3compartmentss Human 95% 0.834 mg/L 2.718 mg/L 0.306843267108168 +DTXSID6047101 Css 3compartmentss Human 95% 0.3533 mg/L 3.864 mg/L 0.0914337474120083 +DTXSID6047103 Css 3compartmentss Human 95% 10.79 mg/L 114.7 mg/L 0.0940714908456844 +DTXSID6047105 Css 3compartmentss Human 95% 0.4466 mg/L 0.7031 mg/L 0.635187028872138 +DTXSID6047109 Css 3compartmentss Human 95% 1.111 mg/L NA NA NA +DTXSID6047155 Css 3compartmentss Human 95% 5.006 mg/L 5.933 mg/L 0.84375526714984 +DTXSID6047157 Css 3compartmentss Human 95% 5.41 mg/L 11.41 mg/L 0.474145486415425 +DTXSID6047159 Css 3compartmentss Human 95% 10.62 mg/L NA NA NA +DTXSID6047280 Css 3compartmentss Human 95% 3.299 mg/L 0.5762 mg/L 5.72544255466852 +DTXSID6047282 Css 3compartmentss Human 95% 66.7 mg/L 75.08 mg/L 0.888385721896644 +DTXSID6047284 Css 3compartmentss Human 95% 0.914 mg/L 0.4358 mg/L 2.09729233593391 +DTXSID6047286 Css 3compartmentss Human 95% 5.628 mg/L 3.075 mg/L 1.83024390243902 +DTXSID6047311 Css 3compartmentss Human 95% 2.251 mg/L 1.661 mg/L 1.35520770620108 +DTXSID6047313 Css 3compartmentss Human 95% 2.4 mg/L 0.1577 mg/L 15.2187698161065 +DTXSID6047315 Css 3compartmentss Human 95% 6.431 mg/L 32.02 mg/L 0.200843222985634 +DTXSID6047317 Css 3compartmentss Human 95% 8.285 mg/L NA NA NA +DTXSID6047319 Css 3compartmentss Human 95% 60.41 mg/L 29.85 mg/L 2.02378559463987 +DTXSID6047363 Css 3compartmentss Human 95% 0.5609 mg/L 0.571 mg/L 0.98231173380035 +DTXSID6047369 Css 3compartmentss Human 95% 1.9 mg/L 33.88 mg/L 0.0560802833530106 +DTXSID6047440 Css 3compartmentss Human 95% 1.615 mg/L NA NA NA +DTXSID6047444 Css 3compartmentss Human 95% 0.948 mg/L 3.625 mg/L 0.26151724137931 +DTXSID6047446 Css 3compartmentss Human 95% 8.477 mg/L 5.83 mg/L 1.45403087478559 +DTXSID6047490 Css 3compartmentss Human 95% 19.36 mg/L NA NA NA +DTXSID6047523 Css 3compartmentss Human 95% 0.9297 mg/L 7.255 mg/L 0.128146106133701 +DTXSID6047525 Css 3compartmentss Human 95% 4.342 mg/L 8.16 mg/L 0.532107843137255 +DTXSID6047529 Css 3compartmentss Human 95% 5.004 mg/L 5.385 mg/L 0.92924791086351 +DTXSID6047604 Css 3compartmentss Human 95% 1.393 mg/L NA NA NA +DTXSID6047606 Css 3compartmentss Human 95% 3.42 mg/L NA NA NA +DTXSID6047608 Css 3compartmentss Human 95% 11.31 mg/L NA NA NA +DTXSID6047652 Css 3compartmentss Human 95% 5.4 mg/L NA NA NA +DTXSID6047656 Css 3compartmentss Human 95% 4.573 mg/L 10.9 mg/L 0.41954128440367 +DTXSID6047781 Css 3compartmentss Human 95% 0.3245 mg/L 0.6339 mg/L 0.511910395961508 +DTXSID6047783 Css 3compartmentss Human 95% 0.3742 mg/L 29.36 mg/L 0.0127452316076294 +DTXSID6047785 Css 3compartmentss Human 95% 1.03 mg/L 2.764 mg/L 0.372648335745297 +DTXSID6047787 Css 3compartmentss Human 95% 1.146 mg/L 0.9702 mg/L 1.18119975262832 +DTXSID6047789 Css 3compartmentss Human 95% 6.556 mg/L 1.793 mg/L 3.65644171779141 +DTXSID6047810 Css 3compartmentss Human 95% 0.2764 mg/L 4.655 mg/L 0.0593770139634801 +DTXSID6047818 Css 3compartmentss Human 95% 0.5434 mg/L 2.632 mg/L 0.20645896656535 +DTXSID6048171 Css 3compartmentss Human 95% 21.2 mg/L 20.97 mg/L 1.01096804959466 +DTXSID6048175 Css 3compartmentss Human 95% 32.87 mg/L 12.9 mg/L 2.54806201550388 +DTXSID6048200 Css 3compartmentss Human 95% 1.96 mg/L 70.59 mg/L 0.0277659725173537 +DTXSID6048202 Css 3compartmentss Human 95% 2.054 mg/L NA NA NA +DTXSID6048204 Css 3compartmentss Human 95% 2.061 mg/L 14.98 mg/L 0.13758344459279 +DTXSID6048208 Css 3compartmentss Human 95% 1.847 mg/L 0.2156 mg/L 8.56679035250464 +DTXSID6048333 Css 3compartmentss Human 95% 6.787 mg/L 23.96 mg/L 0.283263772954925 +DTXSID6048337 Css 3compartmentss Human 95% 0.2351 mg/L NA NA NA +DTXSID6048339 Css 3compartmentss Human 95% 0.9492 mg/L NA NA NA +DTXSID6048383 Css 3compartmentss Human 95% 0.5287 mg/L 8.509 mg/L 0.0621342108355858 +DTXSID6048385 Css 3compartmentss Human 95% 23.99 mg/L NA NA NA +DTXSID6048414 Css 3compartmentss Human 95% 0.3175 mg/L NA NA NA +DTXSID6048462 Css 3compartmentss Human 95% 6.237 mg/L NA NA NA +DTXSID6048464 Css 3compartmentss Human 95% 0.5922 mg/L NA NA NA +DTXSID6048543 Css 3compartmentss Human 95% 0.2452 mg/L NA NA NA +DTXSID6048549 Css 3compartmentss Human 95% 9.167 mg/L NA NA NA +DTXSID6048591 Css 3compartmentss Human 95% 4.656 mg/L 7.534 mg/L 0.6179984072206 +DTXSID6048593 Css 3compartmentss Human 95% 1.095 mg/L 5.913 mg/L 0.185185185185185 +DTXSID6048595 Css 3compartmentss Human 95% 0.9151 mg/L 0.1096 mg/L 8.34945255474453 +DTXSID6048597 Css 3compartmentss Human 95% 1.274 mg/L 59.23 mg/L 0.0215093702515617 +DTXSID6048599 Css 3compartmentss Human 95% 0.08803 mg/L 0.1018 mg/L 0.864734774066798 +DTXSID6048620 Css 3compartmentss Human 95% 6.069 mg/L 0.4626 mg/L 13.1193255512322 +DTXSID6048622 Css 3compartmentss Human 95% 3.992 mg/L 53.18 mg/L 0.0750658142158706 +DTXSID6048624 Css 3compartmentss Human 95% 0.5761 mg/L 24.16 mg/L 0.0238451986754967 +DTXSID6048626 Css 3compartmentss Human 95% 1.9 mg/L 43.97 mg/L 0.0432112804184671 +DTXSID6048628 Css 3compartmentss Human 95% 12.35 mg/L 9.631 mg/L 1.28231751635344 +DTXSID6048670 Css 3compartmentss Human 95% 15.43 mg/L 192.5 mg/L 0.0801558441558442 +DTXSID6048672 Css 3compartmentss Human 95% 0.584 mg/L 1.284 mg/L 0.454828660436137 +DTXSID6048674 Css 3compartmentss Human 95% 1.486 mg/L 0.2507 mg/L 5.92740327084164 +DTXSID6048676 Css 3compartmentss Human 95% 1.108 mg/L 0.2087 mg/L 5.30905606133206 +DTXSID6048678 Css 3compartmentss Human 95% 5.098 mg/L 5.589 mg/L 0.912148863839685 +DTXSID6048705 Css 3compartmentss Human 95% 7.679 mg/L 23.03 mg/L 0.333434650455927 +DTXSID6048707 Css 3compartmentss Human 95% 0.02285 mg/L 0.0205 mg/L 1.11463414634146 +DTXSID6048709 Css 3compartmentss Human 95% 6.003 mg/L 7.662 mg/L 0.783476898981989 +DTXSID6048751 Css 3compartmentss Human 95% 2.161 mg/L 6.903 mg/L 0.313052296103144 +DTXSID6048757 Css 3compartmentss Human 95% 1.04 mg/L 1.194 mg/L 0.871021775544389 +DTXSID6048759 Css 3compartmentss Human 95% 2.803 mg/L 3.389 mg/L 0.827087636470935 +DTXSID6048830 Css 3compartmentss Human 95% 32.88 mg/L 146.4 mg/L 0.224590163934426 +DTXSID6048832 Css 3compartmentss Human 95% 6.718 mg/L 0.251 mg/L 26.7649402390438 +DTXSID6048834 Css 3compartmentss Human 95% 2.054 mg/L 19.46 mg/L 0.105549845837616 +DTXSID6048836 Css 3compartmentss Human 95% 1.224 mg/L 0.3046 mg/L 4.01838476690742 +DTXSID6048838 Css 3compartmentss Human 95% 1.196 mg/L 1.963 mg/L 0.609271523178808 +DTXSID6048880 Css 3compartmentss Human 95% 0.8721 mg/L 0.04997 mg/L 17.4524714828897 +DTXSID6048882 Css 3compartmentss Human 95% 0.4022 mg/L 0.08216 mg/L 4.89532619279455 +DTXSID6048884 Css 3compartmentss Human 95% 0.2612 mg/L 0.02434 mg/L 10.7313064913722 +DTXSID6048886 Css 3compartmentss Human 95% 5.721 mg/L 0.03987 mg/L 143.491346877351 +DTXSID6048888 Css 3compartmentss Human 95% 0.3096 mg/L 0.02779 mg/L 11.1406980928392 +DTXSID6048911 Css 3compartmentss Human 95% 0.297 mg/L 0.8046 mg/L 0.369127516778523 +DTXSID6048913 Css 3compartmentss Human 95% 1.264 mg/L NA NA NA +DTXSID6048915 Css 3compartmentss Human 95% 6.906 mg/L 4.241 mg/L 1.62838953077104 +DTXSID6048917 Css 3compartmentss Human 95% 1.477 mg/L 1.583 mg/L 0.933038534428301 +DTXSID6048919 Css 3compartmentss Human 95% 8.715 mg/L 9.751 mg/L 0.893754486719311 +DTXSID6048961 Css 3compartmentss Human 95% 3.848 mg/L 7.684 mg/L 0.500780843310776 +DTXSID6048963 Css 3compartmentss Human 95% 5.24 mg/L 5.838 mg/L 0.897567660157588 +DTXSID6048965 Css 3compartmentss Human 95% 0.6889 mg/L 3.235 mg/L 0.212952086553323 +DTXSID6048967 Css 3compartmentss Human 95% 14.17 mg/L 17.41 mg/L 0.813900057438254 +DTXSID6048969 Css 3compartmentss Human 95% 5.75 mg/L 1.946 mg/L 2.95477903391572 +DTXSID6049010 Css 3compartmentss Human 95% 2.558 mg/L 1.636 mg/L 1.56356968215159 +DTXSID6049016 Css 3compartmentss Human 95% 0.902 mg/L 0.9302 mg/L 0.969683938937863 +DTXSID6049018 Css 3compartmentss Human 95% 0.3836 mg/L 5.779 mg/L 0.0663782661360097 +DTXSID6049060 Css 3compartmentss Human 95% 1.35 mg/L 1.176 mg/L 1.14795918367347 +DTXSID6049062 Css 3compartmentss Human 95% 1.841 mg/L 2.455 mg/L 0.74989816700611 +DTXSID6049064 Css 3compartmentss Human 95% 1.081 mg/L 1.273 mg/L 0.84917517674784 +DTXSID6049066 Css 3compartmentss Human 95% 19.82 mg/L 0.5745 mg/L 34.4995648389904 +DTXSID6049068 Css 3compartmentss Human 95% 4.857 mg/L 0.1139 mg/L 42.6426690079017 +DTXSID6049220 Css 3compartmentss Human 95% 7.898 mg/L 4.697 mg/L 1.68149882903981 +DTXSID6049222 Css 3compartmentss Human 95% 1.702 mg/L 10.02 mg/L 0.169860279441118 +DTXSID6049226 Css 3compartmentss Human 95% 7.194 mg/L 1.214 mg/L 5.92586490939044 +DTXSID6049278 Css 3compartmentss Human 95% 3.41 mg/L NA NA NA +DTXSID6049303 Css 3compartmentss Human 95% 2.433 mg/L 7.226 mg/L 0.336700802657072 +DTXSID6049307 Css 3compartmentss Human 95% 11.65 mg/L 24.99 mg/L 0.466186474589836 +DTXSID6049309 Css 3compartmentss Human 95% 7.44 mg/L 0.2699 mg/L 27.5657650981845 +DTXSID6049357 Css 3compartmentss Human 95% 12.18 mg/L 14.15 mg/L 0.860777385159011 +DTXSID6049430 Css 3compartmentss Human 95% 2.652 mg/L NA NA NA +DTXSID6049432 Css 3compartmentss Human 95% 1.269 mg/L 1.44 mg/L 0.88125 +DTXSID6051306 Css 3compartmentss Human 95% 4.367 mg/L 0.3028 mg/L 14.4220607661823 +DTXSID6051560 Css 3compartmentss Human 95% 1.964 mg/L 2.297 mg/L 0.855028297779713 +DTXSID6051564 Css 3compartmentss Human 95% 1.118 mg/L NA NA NA +DTXSID6051566 Css 3compartmentss Human 95% 4.329 mg/L 7.041 mg/L 0.614827439284192 +DTXSID6051643 Css 3compartmentss Human 95% 15.56 mg/L NA NA NA +DTXSID6051724 Css 3compartmentss Human 95% 2.376 mg/L 1.603 mg/L 1.48222083593263 +DTXSID6051774 Css 3compartmentss Human 95% 1.781 mg/L NA NA NA +DTXSID6051778 Css 3compartmentss Human 95% 9.961 mg/L 0.8461 mg/L 11.7728400898239 +DTXSID6052295 Css 3compartmentss Human 95% 4.971 mg/L 1.151 mg/L 4.31885317115552 +DTXSID6052326 Css 3compartmentss Human 95% 1.25 mg/L NA NA NA +DTXSID6052328 Css 3compartmentss Human 95% 0.6971 mg/L 2.907 mg/L 0.239800481596147 +DTXSID6052536 Css 3compartmentss Human 95% 5.719 mg/L 5.179 mg/L 1.10426723305657 +DTXSID6052588 Css 3compartmentss Human 95% 0.5456 mg/L NA NA NA +DTXSID6052617 Css 3compartmentss Human 95% 7.084 mg/L NA NA NA +DTXSID6052619 Css 3compartmentss Human 95% 4.305 mg/L 11.87 mg/L 0.36267902274642 +DTXSID60552651 Css 3compartmentss Human 95% 37.57 mg/L NA NA NA +DTXSID6057611 Css 3compartmentss Human 95% 0.7806 mg/L 30.17 mg/L 0.0258733841564468 +DTXSID6057613 Css 3compartmentss Human 95% 14.29 mg/L 1.756 mg/L 8.1378132118451 +DTXSID6057615 Css 3compartmentss Human 95% 3.503 mg/L 12.05 mg/L 0.290705394190871 +DTXSID6057617 Css 3compartmentss Human 95% 1.299 mg/L 0.9343 mg/L 1.3903457133683 +DTXSID6057619 Css 3compartmentss Human 95% 10.84 mg/L 8.253 mg/L 1.31346177147704 +DTXSID6057661 Css 3compartmentss Human 95% 36.71 mg/L 5.017 mg/L 7.31712178592784 +DTXSID6057663 Css 3compartmentss Human 95% 2.363 mg/L 16.19 mg/L 0.145954292773317 +DTXSID6057665 Css 3compartmentss Human 95% 0.3947 mg/L 0.1981 mg/L 1.99242806663301 +DTXSID6057667 Css 3compartmentss Human 95% 0.9314 mg/L 2.652 mg/L 0.351206636500754 +DTXSID6057669 Css 3compartmentss Human 95% 35.78 mg/L 21.49 mg/L 1.6649604467194 +DTXSID6057740 Css 3compartmentss Human 95% 1.387 mg/L 0.3664 mg/L 3.78548034934498 +DTXSID6057742 Css 3compartmentss Human 95% 12.73 mg/L 28.14 mg/L 0.452380952380952 +DTXSID6057744 Css 3compartmentss Human 95% 11.45 mg/L 2.554 mg/L 4.48316366483947 +DTXSID6057746 Css 3compartmentss Human 95% 3.216 mg/L 6.829 mg/L 0.47093278664519 +DTXSID6057748 Css 3compartmentss Human 95% 4.549 mg/L 9.93 mg/L 0.458106747230614 +DTXSID6057790 Css 3compartmentss Human 95% 7.137 mg/L 8.334 mg/L 0.856371490280778 +DTXSID6057794 Css 3compartmentss Human 95% 9.067 mg/L 0.5777 mg/L 15.6949974034966 +DTXSID6057796 Css 3compartmentss Human 95% 7.507 mg/L 9.266 mg/L 0.810166199007123 +DTXSID6057798 Css 3compartmentss Human 95% 5.651 mg/L 4.69 mg/L 1.20490405117271 +DTXSID6057821 Css 3compartmentss Human 95% 5.158 mg/L 9.855 mg/L 0.523389142567225 +DTXSID6057823 Css 3compartmentss Human 95% 22.18 mg/L 6.038 mg/L 3.67340178867175 +DTXSID6057825 Css 3compartmentss Human 95% 4.197 mg/L 1.275 mg/L 3.29176470588235 +DTXSID6057827 Css 3compartmentss Human 95% 4.335 mg/L 6.885 mg/L 0.62962962962963 +DTXSID6057829 Css 3compartmentss Human 95% 0.4967 mg/L 0.2963 mg/L 1.67634154573068 +DTXSID6057875 Css 3compartmentss Human 95% 10.57 mg/L NA NA NA +DTXSID6057900 Css 3compartmentss Human 95% 1.528 mg/L NA NA NA +DTXSID6058631 Css 3compartmentss Human 95% 8.235 mg/L NA NA NA +DTXSID6058689 Css 3compartmentss Human 95% 7.42 mg/L NA NA NA +DTXSID6060632 Css 3compartmentss Human 95% 14.03 mg/L NA NA NA +DTXSID6060769 Css 3compartmentss Human 95% 0.809 mg/L NA NA NA +DTXSID6063143 Css 3compartmentss Human 95% 21.67 mg/L NA NA NA +DTXSID6063351 Css 3compartmentss Human 95% 9.613 mg/L NA NA NA +DTXSID60838720 Css 3compartmentss Human 95% 0.6032 mg/L NA NA NA +DTXSID60860001 Css 3compartmentss Human 95% 0.3536 mg/L NA NA NA +DTXSID60860142 Css 3compartmentss Human 95% 0.5478 mg/L NA NA NA +DTXSID60860420 Css 3compartmentss Human 95% 2.213 mg/L NA NA NA +DTXSID60861376 Css 3compartmentss Human 95% 1.002 mg/L NA NA NA +DTXSID60863012 Css 3compartmentss Human 95% 20.77 mg/L NA NA NA +DTXSID60869332 Css 3compartmentss Human 95% 2.883 mg/L NA NA NA +DTXSID60869418 Css 3compartmentss Human 95% 6.698 mg/L NA NA NA +DTXSID60870165 Css 3compartmentss Human 95% 1.188 mg/L NA NA NA +DTXSID60871172 Css 3compartmentss Human 95% 15.18 mg/L NA NA NA +DTXSID60872346 Css 3compartmentss Human 95% 0.3864 mg/L NA NA NA +DTXSID60873338 Css 3compartmentss Human 95% 0.2089 mg/L NA NA NA +DTXSID60873378 Css 3compartmentss Human 95% 5.115 mg/L NA NA NA +DTXSID60880663 Css 3compartmentss Human 95% 18.29 mg/L NA NA NA +DTXSID60880668 Css 3compartmentss Human 95% 0.3732 mg/L NA NA NA +DTXSID60880688 Css 3compartmentss Human 95% 16.33 mg/L NA NA NA +DTXSID60880724 Css 3compartmentss Human 95% 2.915 mg/L NA NA NA +DTXSID60880769 Css 3compartmentss Human 95% 3.338 mg/L NA NA NA +DTXSID60880820 Css 3compartmentss Human 95% 0.584 mg/L NA NA NA +DTXSID60880840 Css 3compartmentss Human 95% 10.58 mg/L NA NA NA +DTXSID60880880 Css 3compartmentss Human 95% 12.05 mg/L NA NA NA +DTXSID60880885 Css 3compartmentss Human 95% 1.792 mg/L NA NA NA +DTXSID60880901 Css 3compartmentss Human 95% 1.973 mg/L NA NA NA +DTXSID60880921 Css 3compartmentss Human 95% 6.307 mg/L NA NA NA +DTXSID60893450 Css 3compartmentss Human 95% 8.951 mg/L NA NA NA +DTXSID60927527 Css 3compartmentss Human 95% 1.634 mg/L NA NA NA +DTXSID60998873 Css 3compartmentss Human 95% 0.6316 mg/L NA NA NA +DTXSID701007266 Css 3compartmentss Human 95% 4.153 mg/L NA NA NA +DTXSID701009329 Css 3compartmentss Human 95% 3.501 mg/L NA NA NA +DTXSID701105307 Css 3compartmentss Human 95% 8.601 mg/L NA NA NA +DTXSID701108218 Css 3compartmentss Human 95% 1.779 mg/L NA NA NA +DTXSID701188254 Css 3compartmentss Human 95% 0.5025 mg/L NA NA NA +DTXSID70147214 Css 3compartmentss Human 95% 2.175 mg/L NA NA NA +DTXSID70152666 Css 3compartmentss Human 95% 16.3 mg/L NA NA NA +DTXSID70153355 Css 3compartmentss Human 95% 9.666 mg/L NA NA NA +DTXSID70156003 Css 3compartmentss Human 95% 4.848 mg/L NA NA NA +DTXSID70157318 Css 3compartmentss Human 95% 1.259 mg/L NA NA NA +DTXSID70157878 Css 3compartmentss Human 95% 13.03 mg/L NA NA NA +DTXSID70163777 Css 3compartmentss Human 95% 2.475 mg/L NA NA NA +DTXSID70169794 Css 3compartmentss Human 95% 2.472 mg/L NA NA NA +DTXSID70173593 Css 3compartmentss Human 95% 19.14 mg/L 23.42 mg/L 0.817250213492741 +DTXSID70175517 Css 3compartmentss Human 95% 3.359 mg/L NA NA NA +DTXSID70180348 Css 3compartmentss Human 95% 5.189 mg/L NA NA NA +DTXSID70183137 Css 3compartmentss Human 95% 13.44 mg/L NA NA NA +DTXSID70190200 Css 3compartmentss Human 95% 18.77 mg/L NA NA NA +DTXSID70190563 Css 3compartmentss Human 95% 10.6 mg/L NA NA NA +DTXSID70197375 Css 3compartmentss Human 95% 20.03 mg/L NA NA NA +DTXSID70197572 Css 3compartmentss Human 95% 0.9764 mg/L NA NA NA +DTXSID70199490 Css 3compartmentss Human 95% 163.6 mg/L NA NA NA +DTXSID7020005 Css 3compartmentss Human 95% 5.546 mg/L 6.207 mg/L 0.893507330433382 +DTXSID7020007 Css 3compartmentss Human 95% 2.026 mg/L 18.06 mg/L 0.11218161683278 +DTXSID7020053 Css 3compartmentss Human 95% 0.4773 mg/L 0.7232 mg/L 0.659983407079646 +DTXSID7020057 Css 3compartmentss Human 95% 8.032 mg/L 49.12 mg/L 0.163517915309446 +DTXSID7020138 Css 3compartmentss Human 95% 0.7278 mg/L 1.533 mg/L 0.474755381604697 +DTXSID7020182 Css 3compartmentss Human 95% 4.224 mg/L 5.066 mg/L 0.833793920252665 +DTXSID7020184 Css 3compartmentss Human 95% 817.4 mg/L 962.3 mg/L 0.84942325678063 +DTXSID7020211 Css 3compartmentss Human 95% 3.165 mg/L 3.31 mg/L 0.95619335347432 +DTXSID7020213 Css 3compartmentss Human 95% 7.908 mg/L 5.125 mg/L 1.5430243902439 +DTXSID7020261 Css 3compartmentss Human 95% 7.896 mg/L 7.913 mg/L 0.997851636547454 +DTXSID7020263 Css 3compartmentss Human 95% 17.16 mg/L 71.67 mg/L 0.239430724152365 +DTXSID7020265 Css 3compartmentss Human 95% 4.197 mg/L 4.511 mg/L 0.930392374196409 +DTXSID7020342 Css 3compartmentss Human 95% 1.265 mg/L 0.006339 mg/L 199.558289951096 +DTXSID7020344 Css 3compartmentss Human 95% 2.027 mg/L 97.57 mg/L 0.0207748283283796 +DTXSID7020348 Css 3compartmentss Human 95% 14.66 mg/L 15.29 mg/L 0.958796599084369 +DTXSID7020390 Css 3compartmentss Human 95% 4.517 mg/L 5.566 mg/L 0.811534315486885 +DTXSID7020392 Css 3compartmentss Human 95% 25.28 mg/L 26.31 mg/L 0.960851387305207 +DTXSID7020398 Css 3compartmentss Human 95% 7.34 mg/L 0.1072 mg/L 68.4701492537313 +DTXSID7020423 Css 3compartmentss Human 95% 7.097 mg/L 7.623 mg/L 0.930998294634658 +DTXSID7020425 Css 3compartmentss Human 95% 4.846 mg/L NA NA NA +DTXSID7020427 Css 3compartmentss Human 95% 2.056 mg/L 2.714 mg/L 0.757553426676492 +DTXSID7020475 Css 3compartmentss Human 95% 1.822 mg/L NA NA NA +DTXSID7020479 Css 3compartmentss Human 95% 0.8735 mg/L 0.8708 mg/L 1.00310059715204 +DTXSID7020504 Css 3compartmentss Human 95% 0.8755 mg/L 0.9197 mg/L 0.951940850277264 +DTXSID7020550 Css 3compartmentss Human 95% 5.963 mg/L 1.172 mg/L 5.08788395904437 +DTXSID7020552 Css 3compartmentss Human 95% 1.052 mg/L 0.877 mg/L 1.19954389965792 +DTXSID7020558 Css 3compartmentss Human 95% 0.5841 mg/L 0.8034 mg/L 0.727035100821509 +DTXSID7020631 Css 3compartmentss Human 95% 3.225 mg/L 7.022 mg/L 0.459270863001994 +DTXSID7020635 Css 3compartmentss Human 95% 0.4533 mg/L 1.624 mg/L 0.279125615763547 +DTXSID7020685 Css 3compartmentss Human 95% 134.1 mg/L 152.5 mg/L 0.879344262295082 +DTXSID7020687 Css 3compartmentss Human 95% 175.7 mg/L 196.3 mg/L 0.895058583800306 +DTXSID7020714 Css 3compartmentss Human 95% 1.63 mg/L 1.633 mg/L 0.998162890385793 +DTXSID7020716 Css 3compartmentss Human 95% 0.3259 mg/L 0.4887 mg/L 0.666871291180683 +DTXSID70207342 Css 3compartmentss Human 95% 28.14 mg/L NA NA NA +DTXSID7020760 Css 3compartmentss Human 95% 5.488 mg/L 0.156 mg/L 35.1794871794872 +DTXSID7020762 Css 3compartmentss Human 95% 1.74 mg/L 2.1 mg/L 0.828571428571429 +DTXSID7020764 Css 3compartmentss Human 95% 1.785 mg/L 1.922 mg/L 0.928720083246618 +DTXSID7020766 Css 3compartmentss Human 95% 1.533 mg/L 2.496 mg/L 0.614182692307692 +DTXSID7020768 Css 3compartmentss Human 95% 2.046 mg/L 28.95 mg/L 0.0706735751295337 +DTXSID7020841 Css 3compartmentss Human 95% 10.35 mg/L 15.05 mg/L 0.687707641196013 +DTXSID7020847 Css 3compartmentss Human 95% 6.555 mg/L 14.41 mg/L 0.454892435808466 +DTXSID7020893 Css 3compartmentss Human 95% 0.8007 mg/L 0.474 mg/L 1.68924050632911 +DTXSID7020897 Css 3compartmentss Human 95% 2.873 mg/L 74.02 mg/L 0.0388138340988922 +DTXSID7020920 Css 3compartmentss Human 95% 1.633 mg/L 3.238 mg/L 0.504323656578135 +DTXSID7020922 Css 3compartmentss Human 95% 1.899 mg/L 8.952 mg/L 0.212131367292225 +DTXSID7020970 Css 3compartmentss Human 95% 24.15 mg/L NA NA NA +DTXSID7020972 Css 3compartmentss Human 95% 4.347 mg/L 5.519 mg/L 0.787642688892915 +DTXSID7020978 Css 3compartmentss Human 95% 3.237 mg/L 5.619 mg/L 0.576081153230112 +DTXSID70209826 Css 3compartmentss Human 95% 1.984 mg/L NA NA NA +DTXSID7021027 Css 3compartmentss Human 95% 4.414 mg/L 5.469 mg/L 0.807094532821357 +DTXSID7021029 Css 3compartmentss Human 95% 4.644 mg/L NA NA NA +DTXSID7021073 Css 3compartmentss Human 95% 697.5 mg/L NA NA NA +DTXSID7021100 Css 3compartmentss Human 95% 14.71 mg/L 17.92 mg/L 0.820870535714286 +DTXSID7021102 Css 3compartmentss Human 95% 1.298 mg/L 12.05 mg/L 0.107717842323651 +DTXSID70211040 Css 3compartmentss Human 95% 4.451 mg/L NA NA NA +DTXSID7021106 Css 3compartmentss Human 95% 23.41 mg/L 27.63 mg/L 0.847267462902642 +DTXSID70211363 Css 3compartmentss Human 95% 12.38 mg/L NA NA NA +DTXSID7021156 Css 3compartmentss Human 95% 8.571 mg/L 0.01098 mg/L 780.601092896175 +DTXSID7021158 Css 3compartmentss Human 95% 7.533 mg/L 4.617 mg/L 1.63157894736842 +DTXSID7021231 Css 3compartmentss Human 95% 2.911 mg/L 8.623 mg/L 0.337585527078743 +DTXSID7021233 Css 3compartmentss Human 95% 370.9 mg/L 668.4 mg/L 0.55490724117295 +DTXSID7021235 Css 3compartmentss Human 95% 5.744 mg/L 9.573 mg/L 0.600020892092343 +DTXSID7021237 Css 3compartmentss Human 95% 1109 mg/L 1131 mg/L 0.980548187444739 +DTXSID7021239 Css 3compartmentss Human 95% 43.51 mg/L NA NA NA +DTXSID70212557 Css 3compartmentss Human 95% 9.509 mg/L NA NA NA +DTXSID7021287 Css 3compartmentss Human 95% 4.729 mg/L 5.38 mg/L 0.878996282527881 +DTXSID7021289 Css 3compartmentss Human 95% 0.8946 mg/L 0.84 mg/L 1.065 +DTXSID7021310 Css 3compartmentss Human 95% 3.063 mg/L 1.664 mg/L 1.84074519230769 +DTXSID7021312 Css 3compartmentss Human 95% 1.696 mg/L 9.947 mg/L 0.170503669448075 +DTXSID7021314 Css 3compartmentss Human 95% 19.4 mg/L 2.843 mg/L 6.82377769961308 +DTXSID7021316 Css 3compartmentss Human 95% 28.54 mg/L 172.9 mg/L 0.165066512434933 +DTXSID7021362 Css 3compartmentss Human 95% 1.231 mg/L 2.636 mg/L 0.466995447647951 +DTXSID7021364 Css 3compartmentss Human 95% 0.3903 mg/L 2.45 mg/L 0.15930612244898 +DTXSID7021366 Css 3compartmentss Human 95% 0.3385 mg/L 3.346 mg/L 0.101165570830843 +DTXSID7021493 Css 3compartmentss Human 95% 8.959 mg/L NA NA NA +DTXSID7021495 Css 3compartmentss Human 95% 6.426 mg/L 7.404 mg/L 0.867909238249595 +DTXSID7021520 Css 3compartmentss Human 95% 7.576 mg/L 7.921 mg/L 0.95644489332155 +DTXSID7021526 Css 3compartmentss Human 95% 5.803 mg/L 8.019 mg/L 0.723656316248909 +DTXSID70215523 Css 3compartmentss Human 95% 0.6138 mg/L 0.6004 mg/L 1.02231845436376 +DTXSID7021576 Css 3compartmentss Human 95% 3.923 mg/L 4.696 mg/L 0.835391822827939 +DTXSID7021603 Css 3compartmentss Human 95% 6.256 mg/L 620 mg/L 0.0100903225806452 +DTXSID7021605 Css 3compartmentss Human 95% 7.882 mg/L 8.012 mg/L 0.983774338492261 +DTXSID7021607 Css 3compartmentss Human 95% 6.247 mg/L 7.603 mg/L 0.821649348941207 +DTXSID7021655 Css 3compartmentss Human 95% 6.68 mg/L 7.662 mg/L 0.871835030018272 +DTXSID7021657 Css 3compartmentss Human 95% 1.345 mg/L 0.8746 mg/L 1.53784587239881 +DTXSID7021659 Css 3compartmentss Human 95% 7.168 mg/L 8.618 mg/L 0.831747505221629 +DTXSID7021780 Css 3compartmentss Human 95% 0.5267 mg/L 0.4991 mg/L 1.05529953917051 +DTXSID7021782 Css 3compartmentss Human 95% 326.1 mg/L NA NA NA +DTXSID7021784 Css 3compartmentss Human 95% 8.354 mg/L 16.84 mg/L 0.496080760095012 +DTXSID7021788 Css 3compartmentss Human 95% 39.45 mg/L 52.95 mg/L 0.745042492917847 +DTXSID7021815 Css 3compartmentss Human 95% 2.837 mg/L 5.982 mg/L 0.474256101638248 +DTXSID7021817 Css 3compartmentss Human 95% 0.3157 mg/L 7.05 mg/L 0.0447801418439716 +DTXSID7021861 Css 3compartmentss Human 95% 0.5068 mg/L 1.941 mg/L 0.261102524471922 +DTXSID7021863 Css 3compartmentss Human 95% 0.3668 mg/L 0.9157 mg/L 0.40056787157366 +DTXSID7021865 Css 3compartmentss Human 95% 1.928 mg/L NA NA NA +DTXSID7021867 Css 3compartmentss Human 95% 1.794 mg/L 1.27 mg/L 1.41259842519685 +DTXSID7021869 Css 3compartmentss Human 95% 0.201 mg/L 0.2427 mg/L 0.828182941903585 +DTXSID7021940 Css 3compartmentss Human 95% 0.8192 mg/L 2.492 mg/L 0.328731942215088 +DTXSID7021948 Css 3compartmentss Human 95% 1.815 mg/L 1.824 mg/L 0.995065789473684 +DTXSID7021992 Css 3compartmentss Human 95% 2.414 mg/L 2.615 mg/L 0.923135755258126 +DTXSID7021994 Css 3compartmentss Human 95% 7.219 mg/L 4.175 mg/L 1.72910179640719 +DTXSID7021996 Css 3compartmentss Human 95% 7.204 mg/L 8.338 mg/L 0.863996162149197 +DTXSID7021998 Css 3compartmentss Human 95% 2.233 mg/L 6.279 mg/L 0.355629877369008 +DTXSID7022043 Css 3compartmentss Human 95% 6.163 mg/L 10.45 mg/L 0.589760765550239 +DTXSID7022049 Css 3compartmentss Human 95% 0.2203 mg/L 0.2249 mg/L 0.979546465095598 +DTXSID7022120 Css 3compartmentss Human 95% 20.33 mg/L 8.437 mg/L 2.40962427403105 +DTXSID7022128 Css 3compartmentss Human 95% 0.2223 mg/L 5.295 mg/L 0.0419830028328612 +DTXSID7022170 Css 3compartmentss Human 95% 1.43 mg/L 0.8008 mg/L 1.78571428571429 +DTXSID7022172 Css 3compartmentss Human 95% 0.3839 mg/L 0.2305 mg/L 1.66550976138829 +DTXSID7022174 Css 3compartmentss Human 95% 50.71 mg/L 50.9 mg/L 0.996267190569745 +DTXSID7022253 Css 3compartmentss Human 95% 11690 mg/L 13820 mg/L 0.845875542691751 +DTXSID7022332 Css 3compartmentss Human 95% 3.819 mg/L 3.766 mg/L 1.01407328730749 +DTXSID7022382 Css 3compartmentss Human 95% 21.68 mg/L 4.233 mg/L 5.12166312308056 +DTXSID7022384 Css 3compartmentss Human 95% 22.53 mg/L 1.409 mg/L 15.9900638750887 +DTXSID7022411 Css 3compartmentss Human 95% 0.7679 mg/L 0.05483 mg/L 14.005106693416 +DTXSID7022413 Css 3compartmentss Human 95% 2.127 mg/L 0.438 mg/L 4.85616438356164 +DTXSID7022417 Css 3compartmentss Human 95% 1.642 mg/L 0.6938 mg/L 2.36667627558374 +DTXSID7022540 Css 3compartmentss Human 95% 12.35 mg/L 353.4 mg/L 0.0349462365591398 +DTXSID7022544 Css 3compartmentss Human 95% 146 mg/L 122.6 mg/L 1.19086460032626 +DTXSID7022546 Css 3compartmentss Human 95% 5.092 mg/L 5.966 mg/L 0.853503184713376 +DTXSID7022590 Css 3compartmentss Human 95% 6.471 mg/L 2.862 mg/L 2.26100628930818 +DTXSID7022592 Css 3compartmentss Human 95% 24.76 mg/L 8.103 mg/L 3.05565839812415 +DTXSID7022594 Css 3compartmentss Human 95% 1.201 mg/L 1.493 mg/L 0.804420629604823 +DTXSID7022596 Css 3compartmentss Human 95% 73.33 mg/L NA NA NA +DTXSID7022598 Css 3compartmentss Human 95% 1.013 mg/L 1.424 mg/L 0.711376404494382 +DTXSID7022627 Css 3compartmentss Human 95% 0.4903 mg/L NA NA NA +DTXSID7022629 Css 3compartmentss Human 95% 287.9 mg/L 2579 mg/L 0.111632415664986 +DTXSID7022671 Css 3compartmentss Human 95% 2.7 mg/L 7.961 mg/L 0.339153372691873 +DTXSID7022673 Css 3compartmentss Human 95% 2.267 mg/L 6.052 mg/L 0.374586913417052 +DTXSID7022679 Css 3compartmentss Human 95% 4.805 mg/L 0.5215 mg/L 9.21380632790029 +DTXSID7022700 Css 3compartmentss Human 95% 11.16 mg/L NA NA NA +DTXSID7022704 Css 3compartmentss Human 95% 0.4227 mg/L 0.05923 mg/L 7.13658618943103 +DTXSID7022706 Css 3compartmentss Human 95% 1.015 mg/L NA NA NA +DTXSID7022750 Css 3compartmentss Human 95% 6.803 mg/L NA NA NA +DTXSID7022752 Css 3compartmentss Human 95% 4.609 mg/L 7.932 mg/L 0.581064044377206 +DTXSID7022754 Css 3compartmentss Human 95% 5.607 mg/L 4.467 mg/L 1.25520483546004 +DTXSID7022756 Css 3compartmentss Human 95% 16.1 mg/L NA NA NA +DTXSID7022758 Css 3compartmentss Human 95% 195.4 mg/L NA NA NA +DTXSID70227808 Css 3compartmentss Human 95% 2.318 mg/L 2.356 mg/L 0.983870967741936 +DTXSID7022833 Css 3compartmentss Human 95% 0.8236 mg/L 0.2124 mg/L 3.87758945386064 +DTXSID70228330 Css 3compartmentss Human 95% 8.076 mg/L NA NA NA +DTXSID7022835 Css 3compartmentss Human 95% 0.8096 mg/L 8.129 mg/L 0.0995940460081191 +DTXSID7022837 Css 3compartmentss Human 95% 6.227 mg/L 50.29 mg/L 0.123821833366474 +DTXSID7022839 Css 3compartmentss Human 95% 2.799 mg/L 20.79 mg/L 0.134632034632035 +DTXSID70228476 Css 3compartmentss Human 95% 3.47 mg/L NA NA NA +DTXSID7022881 Css 3compartmentss Human 95% 6.214 mg/L NA NA NA +DTXSID7022883 Css 3compartmentss Human 95% 46.49 mg/L 14.17 mg/L 3.28087508821454 +DTXSID7022885 Css 3compartmentss Human 95% 1.704 mg/L NA NA NA +DTXSID7022910 Css 3compartmentss Human 95% 5.209 mg/L 5.669 mg/L 0.918856941259481 +DTXSID7022912 Css 3compartmentss Human 95% 3.854 mg/L 6.878 mg/L 0.56033730735679 +DTXSID7022914 Css 3compartmentss Human 95% 11.21 mg/L 19.1 mg/L 0.586910994764398 +DTXSID7022918 Css 3compartmentss Human 95% 7.611 mg/L 7.391 mg/L 1.02976593153836 +DTXSID7022960 Css 3compartmentss Human 95% 8.019 mg/L NA NA NA +DTXSID7022964 Css 3compartmentss Human 95% 61.43 mg/L NA NA NA +DTXSID7022966 Css 3compartmentss Human 95% 0.3082 mg/L 0.303 mg/L 1.01716171617162 +DTXSID7022968 Css 3compartmentss Human 95% 6.839 mg/L 0.05914 mg/L 115.640852215083 +DTXSID7023011 Css 3compartmentss Human 95% 1.392 mg/L 42.24 mg/L 0.0329545454545455 +DTXSID7023019 Css 3compartmentss Human 95% 3.328 mg/L 2.862 mg/L 1.16282320055905 +DTXSID7023061 Css 3compartmentss Human 95% 8.578 mg/L 1.968 mg/L 4.35873983739837 +DTXSID7023063 Css 3compartmentss Human 95% 11.76 mg/L 1467 mg/L 0.00801635991820041 +DTXSID7023065 Css 3compartmentss Human 95% 4.316 mg/L 4.435 mg/L 0.973167981961669 +DTXSID7023067 Css 3compartmentss Human 95% 6.912 mg/L 8.827 mg/L 0.783051999546845 +DTXSID7023140 Css 3compartmentss Human 95% 19.26 mg/L 9.313 mg/L 2.06807688177816 +DTXSID7023142 Css 3compartmentss Human 95% 4.942 mg/L NA NA NA +DTXSID7023146 Css 3compartmentss Human 95% 5.155 mg/L 5.615 mg/L 0.918076580587711 +DTXSID7023148 Css 3compartmentss Human 95% 78.79 mg/L 90.93 mg/L 0.866490707137358 +DTXSID7023192 Css 3compartmentss Human 95% 6.429 mg/L 7.454 mg/L 0.862489938288167 +DTXSID7023194 Css 3compartmentss Human 95% 2.62 mg/L 0.02195 mg/L 119.362186788155 +DTXSID7023196 Css 3compartmentss Human 95% 6.362 mg/L 32.33 mg/L 0.196783173523044 +DTXSID7023198 Css 3compartmentss Human 95% 7.59 mg/L 15.04 mg/L 0.504654255319149 +DTXSID7023221 Css 3compartmentss Human 95% 1.192 mg/L 0.6574 mg/L 1.81320352905385 +DTXSID7023225 Css 3compartmentss Human 95% 14.3 mg/L 21.33 mg/L 0.670417252695734 +DTXSID7023227 Css 3compartmentss Human 95% 32.91 mg/L 329.1 mg/L 0.1 +DTXSID7023273 Css 3compartmentss Human 95% 94.96 mg/L 117.5 mg/L 0.808170212765957 +DTXSID7023277 Css 3compartmentss Human 95% 2.349 mg/L 1.481 mg/L 1.58609047940581 +DTXSID7023279 Css 3compartmentss Human 95% 1.49 mg/L 7.871 mg/L 0.189302502858595 +DTXSID7023300 Css 3compartmentss Human 95% 1.656 mg/L 1.882 mg/L 0.879914984059511 +DTXSID7023302 Css 3compartmentss Human 95% 0.8763 mg/L 1.259 mg/L 0.696028594122319 +DTXSID7023350 Css 3compartmentss Human 95% 1.272 mg/L 10.54 mg/L 0.120683111954459 +DTXSID7023352 Css 3compartmentss Human 95% 3.914 mg/L 0.04081 mg/L 95.9078657191865 +DTXSID7023354 Css 3compartmentss Human 95% 0.854 mg/L NA NA NA +DTXSID7023356 Css 3compartmentss Human 95% 3.155 mg/L 18.24 mg/L 0.17297149122807 +DTXSID7023431 Css 3compartmentss Human 95% 7.444 mg/L NA NA NA +DTXSID7023433 Css 3compartmentss Human 95% 0.1276 mg/L NA NA NA +DTXSID7023435 Css 3compartmentss Human 95% 4.382 mg/L 4.569 mg/L 0.959072007003721 +DTXSID7023437 Css 3compartmentss Human 95% 7.494 mg/L 0.9489 mg/L 7.89756560227632 +DTXSID7023481 Css 3compartmentss Human 95% 12.03 mg/L 5.68 mg/L 2.11795774647887 +DTXSID7023485 Css 3compartmentss Human 95% 7.323 mg/L 3.227 mg/L 2.26929036256585 +DTXSID7023487 Css 3compartmentss Human 95% 3.437 mg/L 2.083 mg/L 1.65002400384061 +DTXSID7023510 Css 3compartmentss Human 95% 1.254 mg/L 0.4964 mg/L 2.52618855761483 +DTXSID7023512 Css 3compartmentss Human 95% 1.688 mg/L 2.192 mg/L 0.77007299270073 +DTXSID7023514 Css 3compartmentss Human 95% 124.3 mg/L 125.6 mg/L 0.989649681528662 +DTXSID7023516 Css 3compartmentss Human 95% 0.6282 mg/L 4.049 mg/L 0.15514941960978 +DTXSID7023518 Css 3compartmentss Human 95% 2.598 mg/L 6.794 mg/L 0.382396231969385 +DTXSID7023564 Css 3compartmentss Human 95% 0.7891 mg/L NA NA NA +DTXSID7023566 Css 3compartmentss Human 95% 4.348 mg/L 1671 mg/L 0.00260203470975464 +DTXSID7023568 Css 3compartmentss Human 95% 6.304 mg/L 0.4343 mg/L 14.5153119963159 +DTXSID70236238 Css 3compartmentss Human 95% 2.173 mg/L NA NA NA +DTXSID7023643 Css 3compartmentss Human 95% 7.95 mg/L 14.28 mg/L 0.55672268907563 +DTXSID7023645 Css 3compartmentss Human 95% 0.9757 mg/L 1.808 mg/L 0.539657079646018 +DTXSID7023691 Css 3compartmentss Human 95% 5.822 mg/L NA NA NA +DTXSID7023693 Css 3compartmentss Human 95% 3.878 mg/L 12.17 mg/L 0.318652423993426 +DTXSID7023697 Css 3compartmentss Human 95% 17.75 mg/L 1.106 mg/L 16.0488245931284 +DTXSID7023699 Css 3compartmentss Human 95% 1.168 mg/L 14.49 mg/L 0.0806073153899241 +DTXSID7023722 Css 3compartmentss Human 95% 7.639 mg/L 0.1298 mg/L 58.8520801232666 +DTXSID7023724 Css 3compartmentss Human 95% 2.201 mg/L 4.675 mg/L 0.470802139037433 +DTXSID7023853 Css 3compartmentss Human 95% 31.4 mg/L 1391 mg/L 0.0225736879942487 +DTXSID70238611 Css 3compartmentss Human 95% 0.3656 mg/L NA NA NA +DTXSID70239022 Css 3compartmentss Human 95% 5.285 mg/L NA NA NA +DTXSID70239209 Css 3compartmentss Human 95% 0.3763 mg/L NA NA NA +DTXSID7023938 Css 3compartmentss Human 95% 7.211 mg/L 20.53 mg/L 0.351242084754019 +DTXSID7023980 Css 3compartmentss Human 95% 3.678 mg/L 9.516 mg/L 0.386506935687264 +DTXSID7024035 Css 3compartmentss Human 95% 997.4 mg/L 1022 mg/L 0.975929549902153 +DTXSID7024081 Css 3compartmentss Human 95% 2.246 mg/L 2.251 mg/L 0.997778764993336 +DTXSID7024085 Css 3compartmentss Human 95% 7.623 mg/L 9.06 mg/L 0.841390728476821 +DTXSID7024087 Css 3compartmentss Human 95% 6.086 mg/L 3.329 mg/L 1.8281766296185 +DTXSID7024110 Css 3compartmentss Human 95% 20.78 mg/L 3.144 mg/L 6.60941475826972 +DTXSID7024112 Css 3compartmentss Human 95% 175.6 mg/L 204.6 mg/L 0.858260019550342 +DTXSID7024160 Css 3compartmentss Human 95% 812.4 mg/L 831.4 mg/L 0.97714698099591 +DTXSID7024164 Css 3compartmentss Human 95% 78.16 mg/L 78.35 mg/L 0.997574984045948 +DTXSID7024166 Css 3compartmentss Human 95% 5.113 mg/L 5.827 mg/L 0.877466964132487 +DTXSID70241766 Css 3compartmentss Human 95% 39.79 mg/L NA NA NA +DTXSID7024241 Css 3compartmentss Human 95% 777.3 mg/L 833.2 mg/L 0.932909265482477 +DTXSID7024245 Css 3compartmentss Human 95% 56.68 mg/L 49.14 mg/L 1.15343915343915 +DTXSID7024291 Css 3compartmentss Human 95% 13.24 mg/L 3.207 mg/L 4.12846897411911 +DTXSID7024299 Css 3compartmentss Human 95% 2.096 mg/L 1.914 mg/L 1.09508881922675 +DTXSID7024328 Css 3compartmentss Human 95% 1.775 mg/L 1.868 mg/L 0.950214132762312 +DTXSID7024376 Css 3compartmentss Human 95% 11.12 mg/L 11.83 mg/L 0.939983093829248 +DTXSID7024409 Css 3compartmentss Human 95% 0.3759 mg/L 1.118 mg/L 0.336225402504472 +DTXSID7024455 Css 3compartmentss Human 95% 8.29 mg/L 1.93 mg/L 4.29533678756477 +DTXSID7024457 Css 3compartmentss Human 95% 1.396 mg/L 0.9426 mg/L 1.48100997241672 +DTXSID7024532 Css 3compartmentss Human 95% 0.3378 mg/L 0.1034 mg/L 3.2669245647969 +DTXSID7024538 Css 3compartmentss Human 95% 3.375 mg/L 8.789 mg/L 0.384002730686085 +DTXSID7024580 Css 3compartmentss Human 95% 6.812 mg/L 5.674 mg/L 1.20056397603102 +DTXSID7024586 Css 3compartmentss Human 95% 0.885 mg/L 0.4749 mg/L 1.86355022109918 +DTXSID7024619 Css 3compartmentss Human 95% 1.118 mg/L NA NA NA +DTXSID7024667 Css 3compartmentss Human 95% 8.279 mg/L 7.79 mg/L 1.06277278562259 +DTXSID7024827 Css 3compartmentss Human 95% 27.4 mg/L 71.49 mg/L 0.383270387466779 +DTXSID7024873 Css 3compartmentss Human 95% 6.722 mg/L 8.074 mg/L 0.832548922467179 +DTXSID7024875 Css 3compartmentss Human 95% 7.304 mg/L 1.223 mg/L 5.97219950940311 +DTXSID7024902 Css 3compartmentss Human 95% 0.4216 mg/L 0.3897 mg/L 1.08185783936361 +DTXSID7024904 Css 3compartmentss Human 95% 7.447 mg/L 815.8 mg/L 0.00912846285854376 +DTXSID7024956 Css 3compartmentss Human 95% 3.439 mg/L 8.468 mg/L 0.406117146905999 +DTXSID7025001 Css 3compartmentss Human 95% 1.909 mg/L 9.315 mg/L 0.204938271604938 +DTXSID7025003 Css 3compartmentss Human 95% 2.249 mg/L 22.47 mg/L 0.100089007565643 +DTXSID7025005 Css 3compartmentss Human 95% 3.068 mg/L 9.747 mg/L 0.314763516979583 +DTXSID7025051 Css 3compartmentss Human 95% 6.56 mg/L 7.023 mg/L 0.934073757653424 +DTXSID7025132 Css 3compartmentss Human 95% 33.44 mg/L 32.88 mg/L 1.01703163017032 +DTXSID7025134 Css 3compartmentss Human 95% 3.87 mg/L 4.445 mg/L 0.870641169853768 +DTXSID7025136 Css 3compartmentss Human 95% 4.046 mg/L 2.682 mg/L 1.50857568978374 +DTXSID7025138 Css 3compartmentss Human 95% 0.416 mg/L 0.3383 mg/L 1.22967780076855 +DTXSID7025180 Css 3compartmentss Human 95% 11.41 mg/L 12.18 mg/L 0.936781609195402 +DTXSID7025217 Css 3compartmentss Human 95% 2.377 mg/L 137.9 mg/L 0.0172371283538796 +DTXSID7025269 Css 3compartmentss Human 95% 1.453 mg/L 7.711 mg/L 0.188432109972766 +DTXSID7025346 Css 3compartmentss Human 95% 0.4028 mg/L 0.5703 mg/L 0.706294932491671 +DTXSID7025394 Css 3compartmentss Human 95% 7.654 mg/L 0.7259 mg/L 10.5441520870643 +DTXSID7025421 Css 3compartmentss Human 95% 0.3834 mg/L 2.479 mg/L 0.154659136748689 +DTXSID7025423 Css 3compartmentss Human 95% 0.7693 mg/L 0.8826 mg/L 0.871629277135735 +DTXSID7025427 Css 3compartmentss Human 95% 2.95 mg/L 3.442 mg/L 0.857059848925044 +DTXSID7025429 Css 3compartmentss Human 95% 41.04 mg/L 12.01 mg/L 3.41715237302248 +DTXSID7025479 Css 3compartmentss Human 95% 0.9097 mg/L 2.981 mg/L 0.305166051660517 +DTXSID7025502 Css 3compartmentss Human 95% 1.187 mg/L 1.893 mg/L 0.627047015319598 +DTXSID7025506 Css 3compartmentss Human 95% 7.763 mg/L 13.83 mg/L 0.561315979754158 +DTXSID7025508 Css 3compartmentss Human 95% 2.399 mg/L 7.033 mg/L 0.341106213564624 +DTXSID7025558 Css 3compartmentss Human 95% 19.72 mg/L 4.11 mg/L 4.79805352798053 +DTXSID7025633 Css 3compartmentss Human 95% 0.5524 mg/L 1.584 mg/L 0.348737373737374 +DTXSID7025635 Css 3compartmentss Human 95% 0.6053 mg/L 0.5176 mg/L 1.16943585780526 +DTXSID7025637 Css 3compartmentss Human 95% 1.675 mg/L 16.23 mg/L 0.103203943314849 +DTXSID7025639 Css 3compartmentss Human 95% 1.755 mg/L 12.08 mg/L 0.145281456953642 +DTXSID7025689 Css 3compartmentss Human 95% 15.9 mg/L 37.16 mg/L 0.427879440258342 +DTXSID7025716 Css 3compartmentss Human 95% 9.914 mg/L 1.06 mg/L 9.35283018867924 +DTXSID7025764 Css 3compartmentss Human 95% 0.4268 mg/L 0.7627 mg/L 0.559590926969975 +DTXSID7025895 Css 3compartmentss Human 95% 2.045 mg/L 2.213 mg/L 0.924084952553095 +DTXSID7025924 Css 3compartmentss Human 95% 0.4723 mg/L 0.06476 mg/L 7.29308214947498 +DTXSID7025926 Css 3compartmentss Human 95% 0.723 mg/L 0.1308 mg/L 5.52752293577982 +DTXSID7025972 Css 3compartmentss Human 95% 0.656 mg/L 3.768 mg/L 0.174097664543524 +DTXSID7026029 Css 3compartmentss Human 95% 53.1 mg/L 55.62 mg/L 0.954692556634304 +DTXSID7026102 Css 3compartmentss Human 95% 93.05 mg/L 83.56 mg/L 1.11357108664433 +DTXSID7026108 Css 3compartmentss Human 95% 0.03644 mg/L 0.04488 mg/L 0.811942959001782 +DTXSID7026156 Css 3compartmentss Human 95% 0.6153 mg/L 0.9769 mg/L 0.629849524004504 +DTXSID7026231 Css 3compartmentss Human 95% 9.283 mg/L 1.42 mg/L 6.53732394366197 +DTXSID7026235 Css 3compartmentss Human 95% 10.88 mg/L 11.63 mg/L 0.935511607910576 +DTXSID7026285 Css 3compartmentss Human 95% 0.3719 mg/L 0.05603 mg/L 6.63751561663395 +DTXSID7026368 Css 3compartmentss Human 95% 0.742 mg/L 24.62 mg/L 0.0301380991064175 +DTXSID7026499 Css 3compartmentss Human 95% 3.782 mg/L 3.296 mg/L 1.14745145631068 +DTXSID7026520 Css 3compartmentss Human 95% 3.869 mg/L 10.91 mg/L 0.354628780934922 +DTXSID7026526 Css 3compartmentss Human 95% 0.9849 mg/L 1.694 mg/L 0.581404958677686 +DTXSID7026528 Css 3compartmentss Human 95% 1.383 mg/L 3.357 mg/L 0.411974977658624 +DTXSID7026572 Css 3compartmentss Human 95% 4.635 mg/L 4.056 mg/L 1.14275147928994 +DTXSID7026605 Css 3compartmentss Human 95% 3.308 mg/L 2.833 mg/L 1.16766678432757 +DTXSID7026653 Css 3compartmentss Human 95% 3.693 mg/L 16.05 mg/L 0.230093457943925 +DTXSID7026655 Css 3compartmentss Human 95% 1.077 mg/L 1.344 mg/L 0.801339285714286 +DTXSID7026863 Css 3compartmentss Human 95% 5.43 mg/L 5.103 mg/L 1.06407995296884 +DTXSID7026867 Css 3compartmentss Human 95% 7.718 mg/L 2.005 mg/L 3.84937655860349 +DTXSID7027041 Css 3compartmentss Human 95% 0.9195 mg/L 0.6051 mg/L 1.51958353991076 +DTXSID7027043 Css 3compartmentss Human 95% 8.59 mg/L 9.805 mg/L 0.876083630800612 +DTXSID7027047 Css 3compartmentss Human 95% 46.61 mg/L NA NA NA +DTXSID7027097 Css 3compartmentss Human 95% 8.567 mg/L 9.805 mg/L 0.873737888832228 +DTXSID7027120 Css 3compartmentss Human 95% 7.172 mg/L 8.433 mg/L 0.850468397960394 +DTXSID7027122 Css 3compartmentss Human 95% 0.3138 mg/L NA NA NA +DTXSID7027170 Css 3compartmentss Human 95% 6.156 mg/L 7.122 mg/L 0.864363942712721 +DTXSID7027174 Css 3compartmentss Human 95% 0.6055 mg/L 3.126 mg/L 0.193698016634677 +DTXSID7027253 Css 3compartmentss Human 95% 0.4176 mg/L 0.1002 mg/L 4.16766467065868 +DTXSID7027259 Css 3compartmentss Human 95% 0.8657 mg/L 2.069 mg/L 0.418414693088449 +DTXSID7027334 Css 3compartmentss Human 95% 0.5101 mg/L 1.049 mg/L 0.486272640610105 +DTXSID7027413 Css 3compartmentss Human 95% 6.936 mg/L 8.117 mg/L 0.85450289515831 +DTXSID70274236 Css 3compartmentss Human 95% 3.174 mg/L NA NA NA +DTXSID7027461 Css 3compartmentss Human 95% 1.389 mg/L 1.68 mg/L 0.826785714285714 +DTXSID7027540 Css 3compartmentss Human 95% 0.6903 mg/L 2.617 mg/L 0.263775315246465 +DTXSID7027542 Css 3compartmentss Human 95% 4.865 mg/L 91.36 mg/L 0.0532508756567426 +DTXSID7027544 Css 3compartmentss Human 95% 7.206 mg/L 7.549 mg/L 0.954563518346801 +DTXSID7027594 Css 3compartmentss Human 95% 2.423 mg/L 10.07 mg/L 0.240615690168818 +DTXSID7027596 Css 3compartmentss Human 95% 2.053 mg/L 2.315 mg/L 0.88682505399568 +DTXSID7027625 Css 3compartmentss Human 95% 0.8847 mg/L 1.688 mg/L 0.524111374407583 +DTXSID7027756 Css 3compartmentss Human 95% 7.371 mg/L 1.241 mg/L 5.93956486704271 +DTXSID7027833 Css 3compartmentss Human 95% 0.6806 mg/L 2.522 mg/L 0.269865186360032 +DTXSID7027835 Css 3compartmentss Human 95% 6.39 mg/L 6.933 mg/L 0.921678926871484 +DTXSID7027887 Css 3compartmentss Human 95% 0.002453 mg/L 1.067 mg/L 0.00229896907216495 +DTXSID7027966 Css 3compartmentss Human 95% 6.504 mg/L 7.323 mg/L 0.888160589922163 +DTXSID7028013 Css 3compartmentss Human 95% 0.5388 mg/L 0.04671 mg/L 11.5350032113038 +DTXSID7028015 Css 3compartmentss Human 95% 0.4343 mg/L 1.369 mg/L 0.317238860482104 +DTXSID7028300 Css 3compartmentss Human 95% 15.4 mg/L 4.104 mg/L 3.75243664717349 +DTXSID7029160 Css 3compartmentss Human 95% 20.1 mg/L 11190 mg/L 0.00179624664879357 +DTXSID7029162 Css 3compartmentss Human 95% 7.204 mg/L NA NA NA +DTXSID7029164 Css 3compartmentss Human 95% 4.102 mg/L 4.936 mg/L 0.831037277147488 +DTXSID7029166 Css 3compartmentss Human 95% 8.649 mg/L 8.757 mg/L 0.987667009249743 +DTXSID7029241 Css 3compartmentss Human 95% 4.958 mg/L 5.301 mg/L 0.935295227315601 +DTXSID7029247 Css 3compartmentss Human 95% 1.355 mg/L 0.7999 mg/L 1.69396174521815 +DTXSID7029249 Css 3compartmentss Human 95% 10.42 mg/L 1.106 mg/L 9.42133815551537 +DTXSID7029320 Css 3compartmentss Human 95% 24.14 mg/L 234.1 mg/L 0.103118325501922 +DTXSID70293821 Css 3compartmentss Human 95% 8.765 mg/L NA NA NA +DTXSID7029611 Css 3compartmentss Human 95% 3.244 mg/L 0.2643 mg/L 12.2739311388574 +DTXSID7029617 Css 3compartmentss Human 95% 6.125 mg/L 7.122 mg/L 0.860011232799775 +DTXSID7029665 Css 3compartmentss Human 95% 0.3949 mg/L 0.2871 mg/L 1.37547892720306 +DTXSID7029871 Css 3compartmentss Human 95% 5.178 mg/L 4.235 mg/L 1.22266824085006 +DTXSID7029879 Css 3compartmentss Human 95% 2.807 mg/L 3.481 mg/L 0.806377477736283 +DTXSID7030307 Css 3compartmentss Human 95% 0.9195 mg/L 0.8966 mg/L 1.02554093241133 +DTXSID7030432 Css 3compartmentss Human 95% 4.754 mg/L 5.351 mg/L 0.888432068772192 +DTXSID7030698 Css 3compartmentss Human 95% 4.739 mg/L 5.559 mg/L 0.852491455297715 +DTXSID7031248 Css 3compartmentss Human 95% 2.181 mg/L NA NA NA +DTXSID7031290 Css 3compartmentss Human 95% 14.55 mg/L NA NA NA +DTXSID7031294 Css 3compartmentss Human 95% 4.828 mg/L 7.295 mg/L 0.661823166552433 +DTXSID7031458 Css 3compartmentss Human 95% 0.4818 mg/L 3.194 mg/L 0.150845335003131 +DTXSID7031531 Css 3compartmentss Human 95% 13180 mg/L 13730 mg/L 0.959941733430444 +DTXSID7031797 Css 3compartmentss Human 95% 1.354 mg/L 0.5454 mg/L 2.48258159149248 +DTXSID7031903 Css 3compartmentss Human 95% 0.3496 mg/L 8.387 mg/L 0.0416835578872064 +DTXSID7031955 Css 3compartmentss Human 95% 0.3678 mg/L NA NA NA +DTXSID7032004 Css 3compartmentss Human 95% 3.663 mg/L 4.906 mg/L 0.746636771300448 +DTXSID7032006 Css 3compartmentss Human 95% 622.7 mg/L NA NA NA +DTXSID7032345 Css 3compartmentss Human 95% 1042 mg/L 1828 mg/L 0.570021881838074 +DTXSID7032393 Css 3compartmentss Human 95% 37.04 mg/L 36.46 mg/L 1.01590784421284 +DTXSID7032424 Css 3compartmentss Human 95% 5.961 mg/L 8.375 mg/L 0.711761194029851 +DTXSID7032470 Css 3compartmentss Human 95% 28.69 mg/L 28.45 mg/L 1.00843585237258 +DTXSID7032474 Css 3compartmentss Human 95% 5.679 mg/L 10.47 mg/L 0.542406876790831 +DTXSID7032551 Css 3compartmentss Human 95% 36.86 mg/L 36.22 mg/L 1.01766979569299 +DTXSID7032553 Css 3compartmentss Human 95% 4566 mg/L 4695 mg/L 0.972523961661342 +DTXSID7032555 Css 3compartmentss Human 95% 21.97 mg/L 22.77 mg/L 0.964866051822574 +DTXSID7032559 Css 3compartmentss Human 95% 11.5 mg/L 2.766 mg/L 4.15762834417932 +DTXSID7032630 Css 3compartmentss Human 95% 18.69 mg/L 17.84 mg/L 1.04764573991031 +DTXSID7032638 Css 3compartmentss Human 95% 44.12 mg/L 43.52 mg/L 1.01378676470588 +DTXSID7032688 Css 3compartmentss Human 95% 20.55 mg/L 3.025 mg/L 6.79338842975207 +DTXSID7033105 Css 3compartmentss Human 95% 3.901 mg/L 7.818 mg/L 0.498976720388846 +DTXSID70333438 Css 3compartmentss Human 95% 1.143 mg/L NA NA NA +DTXSID70340061 Css 3compartmentss Human 95% 13.1 mg/L NA NA NA +DTXSID7034250 Css 3compartmentss Human 95% 11.86 mg/L 0.8317 mg/L 14.259949501022 +DTXSID7034252 Css 3compartmentss Human 95% 3.401 mg/L 3.453 mg/L 0.984940631335071 +DTXSID7034383 Css 3compartmentss Human 95% 228.9 mg/L 286.2 mg/L 0.79979035639413 +DTXSID70344382 Css 3compartmentss Human 95% 1.713 mg/L NA NA NA +DTXSID7034460 Css 3compartmentss Human 95% 1.977 mg/L 163 mg/L 0.0121288343558282 +DTXSID7034545 Css 3compartmentss Human 95% 2.166 mg/L 2.256 mg/L 0.960106382978723 +DTXSID7034549 Css 3compartmentss Human 95% 5.786 mg/L 0.5292 mg/L 10.9334845049131 +DTXSID7034624 Css 3compartmentss Human 95% 2.057 mg/L 47.75 mg/L 0.0430785340314136 +DTXSID7034674 Css 3compartmentss Human 95% 2.407 mg/L 2.491 mg/L 0.966278602970694 +DTXSID7034676 Css 3compartmentss Human 95% 4.811 mg/L 6.183 mg/L 0.778101245350154 +DTXSID70346760 Css 3compartmentss Human 95% 18.21 mg/L NA NA NA +DTXSID7034753 Css 3compartmentss Human 95% 59.86 mg/L 68.17 mg/L 0.878098870470882 +DTXSID7034961 Css 3compartmentss Human 95% 2.626 mg/L 2.66 mg/L 0.987218045112782 +DTXSID7035010 Css 3compartmentss Human 95% 13.99 mg/L 257.8 mg/L 0.054266873545384 +DTXSID7035305 Css 3compartmentss Human 95% 3.598 mg/L 2.764 mg/L 1.30173661360347 +DTXSID7037131 Css 3compartmentss Human 95% 237.7 mg/L 166.6 mg/L 1.42677070828331 +DTXSID7037262 Css 3compartmentss Human 95% 2.794 mg/L 1.263 mg/L 2.21219319081552 +DTXSID7037478 Css 3compartmentss Human 95% 0.6329 mg/L 1.085 mg/L 0.58331797235023 +DTXSID7037551 Css 3compartmentss Human 95% 0.7853 mg/L 0.8598 mg/L 0.913351942312166 +DTXSID7037553 Css 3compartmentss Human 95% 45.96 mg/L 494.7 mg/L 0.0929047907822923 +DTXSID7037555 Css 3compartmentss Human 95% 20.78 mg/L 3.144 mg/L 6.60941475826972 +DTXSID7037680 Css 3compartmentss Human 95% 2.823 mg/L 6.641 mg/L 0.425086583345882 +DTXSID7037715 Css 3compartmentss Human 95% 4.077 mg/L 6.398 mg/L 0.637230384495155 +DTXSID7037717 Css 3compartmentss Human 95% 3.351 mg/L 2.751 mg/L 1.21810250817884 +DTXSID7038317 Css 3compartmentss Human 95% 2.639 mg/L 322.9 mg/L 0.00817280891917002 +DTXSID7038814 Css 3compartmentss Human 95% 7.55 mg/L 1.431 mg/L 5.27603074772886 +DTXSID7038816 Css 3compartmentss Human 95% 16.4 mg/L NA NA NA +DTXSID7038864 Css 3compartmentss Human 95% 3009 mg/L 2434 mg/L 1.23623664749384 +DTXSID7040152 Css 3compartmentss Human 95% 4.456 mg/L 6.53 mg/L 0.682388973966309 +DTXSID7040154 Css 3compartmentss Human 95% 4.761 mg/L 0.403 mg/L 11.8138957816377 +DTXSID7040283 Css 3compartmentss Human 95% 23.7 mg/L 450.8 mg/L 0.0525732031943212 +DTXSID7040285 Css 3compartmentss Human 95% 0.5864 mg/L 1.147 mg/L 0.511246730601569 +DTXSID7040287 Css 3compartmentss Human 95% 12.76 mg/L 0.6745 mg/L 18.9177168272795 +DTXSID7040289 Css 3compartmentss Human 95% 0.495 mg/L 30.98 mg/L 0.0159780503550678 +DTXSID7040360 Css 3compartmentss Human 95% 13.91 mg/L 20.32 mg/L 0.684547244094488 +DTXSID7040362 Css 3compartmentss Human 95% 0.09399 mg/L 20.6 mg/L 0.0045626213592233 +DTXSID7040526 Css 3compartmentss Human 95% 3.172 mg/L 5.61 mg/L 0.56541889483066 +DTXSID7040609 Css 3compartmentss Human 95% 5.541 mg/L 5.487 mg/L 1.0098414434117 +DTXSID7040651 Css 3compartmentss Human 95% 2.389 mg/L 8.301 mg/L 0.287796651005903 +DTXSID7040653 Css 3compartmentss Human 95% 2.177 mg/L 14.81 mg/L 0.146995273463876 +DTXSID7040655 Css 3compartmentss Human 95% 263.9 mg/L NA NA NA +DTXSID7040657 Css 3compartmentss Human 95% 2.413 mg/L 2.702 mg/L 0.893042190969652 +DTXSID7040732 Css 3compartmentss Human 95% 3.109 mg/L 2.542 mg/L 1.22305271439811 +DTXSID7040734 Css 3compartmentss Human 95% 9.432 mg/L 16.76 mg/L 0.562768496420048 +DTXSID7040736 Css 3compartmentss Human 95% 5.799 mg/L 1.076 mg/L 5.38940520446097 +DTXSID7040738 Css 3compartmentss Human 95% 0.9187 mg/L 7.25 mg/L 0.12671724137931 +DTXSID7040788 Css 3compartmentss Human 95% 9.245 mg/L 9.38 mg/L 0.985607675906183 +DTXSID7040948 Css 3compartmentss Human 95% 0.8593 mg/L 34.84 mg/L 0.0246641791044776 +DTXSID7040990 Css 3compartmentss Human 95% 2.72 mg/L 16.8 mg/L 0.161904761904762 +DTXSID7041045 Css 3compartmentss Human 95% 4.869 mg/L 5.496 mg/L 0.885917030567685 +DTXSID7041047 Css 3compartmentss Human 95% 1.799 mg/L 4.416 mg/L 0.407382246376812 +DTXSID7041091 Css 3compartmentss Human 95% 7.23 mg/L 2.422 mg/L 2.9851362510322 +DTXSID7041097 Css 3compartmentss Human 95% 8.756 mg/L 8.335 mg/L 1.0505098980204 +DTXSID7041178 Css 3compartmentss Human 95% 9.225 mg/L 31.69 mg/L 0.291101293783528 +DTXSID7041201 Css 3compartmentss Human 95% 14.26 mg/L NA NA NA +DTXSID7041209 Css 3compartmentss Human 95% 1.153 mg/L 6.025 mg/L 0.191369294605809 +DTXSID7041253 Css 3compartmentss Human 95% 6.338 mg/L 5.481 mg/L 1.15635832877212 +DTXSID7041336 Css 3compartmentss Human 95% 19.27 mg/L 561 mg/L 0.034349376114082 +DTXSID7041388 Css 3compartmentss Human 95% 8.093 mg/L 2.007 mg/L 4.03238664673642 +DTXSID7041411 Css 3compartmentss Human 95% 1.905 mg/L 7.389 mg/L 0.257815671944783 +DTXSID7041413 Css 3compartmentss Human 95% 0.7069 mg/L NA NA NA +DTXSID7041417 Css 3compartmentss Human 95% 5.058 mg/L 3.219 mg/L 1.5712954333644 +DTXSID7041461 Css 3compartmentss Human 95% 19.54 mg/L 20.76 mg/L 0.941233140655106 +DTXSID7041467 Css 3compartmentss Human 95% 53.05 mg/L 56.78 mg/L 0.934307854878478 +DTXSID7041540 Css 3compartmentss Human 95% 9.033 mg/L 15.38 mg/L 0.587321196358908 +DTXSID7041544 Css 3compartmentss Human 95% 21.27 mg/L NA NA NA +DTXSID7041621 Css 3compartmentss Human 95% 3.6 mg/L 2.002 mg/L 1.7982017982018 +DTXSID7041623 Css 3compartmentss Human 95% 3.088 mg/L 3.172 mg/L 0.973518284993695 +DTXSID7041625 Css 3compartmentss Human 95% 0.3736 mg/L 8.603 mg/L 0.0434267116122283 +DTXSID7041627 Css 3compartmentss Human 95% 0.9716 mg/L 0.4107 mg/L 2.36571706841977 +DTXSID7041629 Css 3compartmentss Human 95% 74.61 mg/L 2.92 mg/L 25.5513698630137 +DTXSID7041752 Css 3compartmentss Human 95% 7.512 mg/L 0.7219 mg/L 10.4058733896662 +DTXSID7041756 Css 3compartmentss Human 95% 0.3674 mg/L 1.315 mg/L 0.279391634980989 +DTXSID7041883 Css 3compartmentss Human 95% 14.15 mg/L 110 mg/L 0.128636363636364 +DTXSID7041887 Css 3compartmentss Human 95% 9.294 mg/L 0.402 mg/L 23.1194029850746 +DTXSID7041889 Css 3compartmentss Human 95% 6.006 mg/L 1.662 mg/L 3.61371841155235 +DTXSID7041910 Css 3compartmentss Human 95% 8.771 mg/L 7.571 mg/L 1.15849953770968 +DTXSID7041914 Css 3compartmentss Human 95% 0.3494 mg/L 0.3759 mg/L 0.92950252726789 +DTXSID7041916 Css 3compartmentss Human 95% 0.3937 mg/L 0.06909 mg/L 5.69836445216384 +DTXSID7041918 Css 3compartmentss Human 95% 6.64 mg/L 4.919 mg/L 1.349867859321 +DTXSID7041964 Css 3compartmentss Human 95% 1.141 mg/L 0.6384 mg/L 1.78728070175439 +DTXSID7041966 Css 3compartmentss Human 95% 0.8877 mg/L 0.9743 mg/L 0.911115672790722 +DTXSID7042011 Css 3compartmentss Human 95% 42.23 mg/L 41.13 mg/L 1.0267444687576 +DTXSID7042019 Css 3compartmentss Human 95% 17.37 mg/L 113.7 mg/L 0.152770448548813 +DTXSID7042063 Css 3compartmentss Human 95% 2.534 mg/L 0.7352 mg/L 3.44668117519042 +DTXSID7042140 Css 3compartmentss Human 95% 0.3986 mg/L 0.5652 mg/L 0.705237084217976 +DTXSID7042146 Css 3compartmentss Human 95% 2.175 mg/L 0.8175 mg/L 2.6605504587156 +DTXSID7042196 Css 3compartmentss Human 95% 0.321 mg/L 7.282 mg/L 0.0440812963471574 +DTXSID7042198 Css 3compartmentss Human 95% 0.7678 mg/L 4.913 mg/L 0.156279259108488 +DTXSID7042273 Css 3compartmentss Human 95% 10.74 mg/L 5.589 mg/L 1.92163177670424 +DTXSID7042279 Css 3compartmentss Human 95% 2.101 mg/L 1.079 mg/L 1.94717330861909 +DTXSID7042352 Css 3compartmentss Human 95% 6.122 mg/L 0.4236 mg/L 14.452313503305 +DTXSID7042437 Css 3compartmentss Human 95% 4.466 mg/L 2.101 mg/L 2.12565445026178 +DTXSID7042481 Css 3compartmentss Human 95% 0.818 mg/L NA NA NA +DTXSID7042514 Css 3compartmentss Human 95% 5.039 mg/L 5.553 mg/L 0.907437421213758 +DTXSID70426091 Css 3compartmentss Human 95% 1.257 mg/L NA NA NA +DTXSID70436993 Css 3compartmentss Human 95% 3.294 mg/L NA NA NA +DTXSID7043829 Css 3compartmentss Human 95% 7.567 mg/L 0.05109 mg/L 148.111176355451 +DTXSID7043873 Css 3compartmentss Human 95% 5.866 mg/L 0.3122 mg/L 18.7892376681614 +DTXSID7043908 Css 3compartmentss Human 95% 1.136 mg/L 0.06682 mg/L 17.0008979347501 +DTXSID7043950 Css 3compartmentss Human 95% 7.243 mg/L 8.509 mg/L 0.851216359149136 +DTXSID7043952 Css 3compartmentss Human 95% 34.53 mg/L 30.46 mg/L 1.13361785948785 +DTXSID7044130 Css 3compartmentss Human 95% 1.072 mg/L 1.28 mg/L 0.8375 +DTXSID7044132 Css 3compartmentss Human 95% 0.9698 mg/L 0.5558 mg/L 1.74487225620727 +DTXSID7044215 Css 3compartmentss Human 95% 14.17 mg/L 2.649 mg/L 5.34918837297093 +DTXSID7044217 Css 3compartmentss Human 95% 2.444 mg/L 213.1 mg/L 0.0114687939934303 +DTXSID7044267 Css 3compartmentss Human 95% 1.581 mg/L 60.16 mg/L 0.026279920212766 +DTXSID7044340 Css 3compartmentss Human 95% 2.112 mg/L 30.22 mg/L 0.0698874917273329 +DTXSID7044342 Css 3compartmentss Human 95% 2.049 mg/L 1.205 mg/L 1.70041493775934 +DTXSID7044346 Css 3compartmentss Human 95% 2.697e-05 mg/L 0.001693 mg/L 0.0159303012404017 +DTXSID7044390 Css 3compartmentss Human 95% 0.8936 mg/L 1.039 mg/L 0.860057747834456 +DTXSID7044396 Css 3compartmentss Human 95% 8.473 mg/L 1.282 mg/L 6.60920436817473 +DTXSID7044398 Css 3compartmentss Human 95% 21.2 mg/L 0.922 mg/L 22.9934924078091 +DTXSID7044421 Css 3compartmentss Human 95% 0.3569 mg/L 1.09 mg/L 0.32743119266055 +DTXSID7044425 Css 3compartmentss Human 95% 4.732 mg/L 8.736 mg/L 0.541666666666667 +DTXSID7044427 Css 3compartmentss Human 95% 1.396 mg/L 1.397 mg/L 0.999284180386543 +DTXSID7044429 Css 3compartmentss Human 95% 4.727 mg/L 35.68 mg/L 0.132483183856502 +DTXSID7044471 Css 3compartmentss Human 95% 0.3644 mg/L 0.1192 mg/L 3.05704697986577 +DTXSID7044473 Css 3compartmentss Human 95% 1.493 mg/L 29.63 mg/L 0.0503881201484981 +DTXSID7044479 Css 3compartmentss Human 95% 1.327 mg/L 0.8092 mg/L 1.63989125061789 +DTXSID7044500 Css 3compartmentss Human 95% 17.14 mg/L 106.1 mg/L 0.161545711592837 +DTXSID7044502 Css 3compartmentss Human 95% 7.322 mg/L 0.05032 mg/L 145.508744038156 +DTXSID7044506 Css 3compartmentss Human 95% 0.7783 mg/L NA NA NA +DTXSID7044554 Css 3compartmentss Human 95% 3.114 mg/L 77.71 mg/L 0.0400720627975808 +DTXSID7044631 Css 3compartmentss Human 95% 1.123 mg/L 1.477 mg/L 0.760324983073798 +DTXSID7044633 Css 3compartmentss Human 95% 3.609 mg/L 11.49 mg/L 0.314099216710183 +DTXSID7044635 Css 3compartmentss Human 95% 0.2827 mg/L 3.175 mg/L 0.0890393700787402 +DTXSID7044639 Css 3compartmentss Human 95% 152.5 mg/L NA NA NA +DTXSID7044681 Css 3compartmentss Human 95% 7.678 mg/L 0.789 mg/L 9.73130544993663 +DTXSID7044685 Css 3compartmentss Human 95% 5.773 mg/L NA NA NA +DTXSID7044687 Css 3compartmentss Human 95% 6.781 mg/L NA NA NA +DTXSID7044689 Css 3compartmentss Human 95% 1.057 mg/L 1.459 mg/L 0.72446881425634 +DTXSID7044710 Css 3compartmentss Human 95% 1.874 mg/L 3.25 mg/L 0.576615384615385 +DTXSID7044712 Css 3compartmentss Human 95% 0.3551 mg/L NA NA NA +DTXSID7044714 Css 3compartmentss Human 95% 4.377 mg/L 4.016 mg/L 1.08989043824701 +DTXSID7044716 Css 3compartmentss Human 95% 0.5728 mg/L 0.9812 mg/L 0.583774969425194 +DTXSID7044718 Css 3compartmentss Human 95% 7.57 mg/L 12.15 mg/L 0.623045267489712 +DTXSID7044762 Css 3compartmentss Human 95% 10.19 mg/L 2.334 mg/L 4.36589545844044 +DTXSID7044764 Css 3compartmentss Human 95% 2.84 mg/L NA NA NA +DTXSID7044768 Css 3compartmentss Human 95% 7.588 mg/L 4.462 mg/L 1.70058269834155 +DTXSID7044841 Css 3compartmentss Human 95% 17.23 mg/L 3076 mg/L 0.00560143042912874 +DTXSID7044843 Css 3compartmentss Human 95% 225.7 mg/L 924.1 mg/L 0.244237636619413 +DTXSID7044845 Css 3compartmentss Human 95% 1.327 mg/L 0.9746 mg/L 1.36158423968808 +DTXSID7044847 Css 3compartmentss Human 95% 0.5799 mg/L 0.0325 mg/L 17.8430769230769 +DTXSID7044849 Css 3compartmentss Human 95% 3.175 mg/L 3.862 mg/L 0.822112894873123 +DTXSID7044893 Css 3compartmentss Human 95% 12.76 mg/L 172.6 mg/L 0.073928157589803 +DTXSID7044895 Css 3compartmentss Human 95% 2.704 mg/L 0.6811 mg/L 3.97004845103509 +DTXSID7044897 Css 3compartmentss Human 95% 5.671 mg/L 4.825 mg/L 1.17533678756477 +DTXSID7044899 Css 3compartmentss Human 95% 6.627 mg/L 0.2086 mg/L 31.7689357622244 +DTXSID7044922 Css 3compartmentss Human 95% 1.766 mg/L 1.834 mg/L 0.962922573609596 +DTXSID7044926 Css 3compartmentss Human 95% 0.1808 mg/L 0.05245 mg/L 3.44709246901811 +DTXSID7044970 Css 3compartmentss Human 95% 4.732 mg/L 16.36 mg/L 0.289242053789731 +DTXSID7044972 Css 3compartmentss Human 95% 14.54 mg/L 202.6 mg/L 0.0717670286278381 +DTXSID7044974 Css 3compartmentss Human 95% 7.676 mg/L 2.882 mg/L 2.66342817487856 +DTXSID7044976 Css 3compartmentss Human 95% 0.397 mg/L 0.7794 mg/L 0.509366179112138 +DTXSID7045021 Css 3compartmentss Human 95% 0.8357 mg/L NA NA NA +DTXSID7045029 Css 3compartmentss Human 95% 4.674 mg/L 10.98 mg/L 0.42568306010929 +DTXSID7045079 Css 3compartmentss Human 95% 6.111 mg/L 7.122 mg/L 0.85804549283909 +DTXSID7045106 Css 3compartmentss Human 95% 1.274 mg/L 21.97 mg/L 0.0579881656804734 +DTXSID7045150 Css 3compartmentss Human 95% 10.96 mg/L 11.66 mg/L 0.939965694682676 +DTXSID7045152 Css 3compartmentss Human 95% 19.39 mg/L 10.08 mg/L 1.92361111111111 +DTXSID7045158 Css 3compartmentss Human 95% 7.746 mg/L 1.125 mg/L 6.88533333333333 +DTXSID7045281 Css 3compartmentss Human 95% 8.394 mg/L 6.544 mg/L 1.28270171149144 +DTXSID7045287 Css 3compartmentss Human 95% 2.531 mg/L 8.642 mg/L 0.292872020365656 +DTXSID7045310 Css 3compartmentss Human 95% 15.77 mg/L 1.705 mg/L 9.24926686217009 +DTXSID7045312 Css 3compartmentss Human 95% 0.5936 mg/L 1.87 mg/L 0.317433155080214 +DTXSID7045316 Css 3compartmentss Human 95% 0.9693 mg/L 0.4927 mg/L 1.96732291455247 +DTXSID7045318 Css 3compartmentss Human 95% 4.526 mg/L 8.094 mg/L 0.559179639238942 +DTXSID7045360 Css 3compartmentss Human 95% 0.5486 mg/L 8.9 mg/L 0.0616404494382022 +DTXSID7045364 Css 3compartmentss Human 95% 7.635 mg/L 2.047 mg/L 3.72984855886663 +DTXSID7045366 Css 3compartmentss Human 95% 4.434 mg/L 3.171 mg/L 1.39829706717124 +DTXSID7045368 Css 3compartmentss Human 95% 1.457 mg/L 3.183 mg/L 0.457744266415332 +DTXSID7045441 Css 3compartmentss Human 95% 0.4689 mg/L 4.09 mg/L 0.114645476772616 +DTXSID7045443 Css 3compartmentss Human 95% 2.436 mg/L 0.5406 mg/L 4.50610432852386 +DTXSID7045447 Css 3compartmentss Human 95% 23.5 mg/L 15.99 mg/L 1.46966854283927 +DTXSID7045493 Css 3compartmentss Human 95% 0.9357 mg/L 1.736 mg/L 0.538997695852535 +DTXSID7045497 Css 3compartmentss Human 95% 2.478 mg/L 18.23 mg/L 0.135929786066923 +DTXSID7045522 Css 3compartmentss Human 95% 15.67 mg/L 31.5 mg/L 0.497460317460317 +DTXSID7045526 Css 3compartmentss Human 95% 3.027 mg/L 1.516 mg/L 1.9967018469657 +DTXSID7045570 Css 3compartmentss Human 95% 3.687 mg/L 39.6 mg/L 0.0931060606060606 +DTXSID7045572 Css 3compartmentss Human 95% 13.18 mg/L 7.264 mg/L 1.81442731277533 +DTXSID7045574 Css 3compartmentss Human 95% 5.209 mg/L 9.316 mg/L 0.559145556032632 +DTXSID7045576 Css 3compartmentss Human 95% 6.362 mg/L 139.1 mg/L 0.0457368799424874 +DTXSID7045578 Css 3compartmentss Human 95% 0.8645 mg/L 4.396 mg/L 0.196656050955414 +DTXSID7045601 Css 3compartmentss Human 95% 7.959 mg/L 0.6551 mg/L 12.1492901847046 +DTXSID7045603 Css 3compartmentss Human 95% 4.195 mg/L 6.325 mg/L 0.663241106719368 +DTXSID7045607 Css 3compartmentss Human 95% 1.612 mg/L 38.2 mg/L 0.0421989528795811 +DTXSID7045651 Css 3compartmentss Human 95% 0.7933 mg/L 2.736 mg/L 0.289948830409357 +DTXSID7045653 Css 3compartmentss Human 95% 3.165 mg/L 1.663 mg/L 1.90318701142514 +DTXSID7045655 Css 3compartmentss Human 95% 4.74 mg/L 52.84 mg/L 0.0897047691143073 +DTXSID7045659 Css 3compartmentss Human 95% 5.725 mg/L 0.6107 mg/L 9.37448829212379 +DTXSID7045780 Css 3compartmentss Human 95% 3.993 mg/L 5.042 mg/L 0.791947639825466 +DTXSID7045782 Css 3compartmentss Human 95% 7.223 mg/L 0.02474 mg/L 291.956345998383 +DTXSID7045786 Css 3compartmentss Human 95% 0.7344 mg/L 9.998 mg/L 0.0734546909381876 +DTXSID7045788 Css 3compartmentss Human 95% 6.901 mg/L 0.3297 mg/L 20.9311495298756 +DTXSID7045811 Css 3compartmentss Human 95% 1.07 mg/L 0.2591 mg/L 4.12967966036279 +DTXSID7045813 Css 3compartmentss Human 95% 2.064 mg/L 9.637 mg/L 0.214174535643873 +DTXSID7045815 Css 3compartmentss Human 95% 1.602 mg/L 4.787 mg/L 0.334656360977648 +DTXSID7045861 Css 3compartmentss Human 95% 1.037 mg/L 0.8598 mg/L 1.20609444056757 +DTXSID7045863 Css 3compartmentss Human 95% 2.28 mg/L 23.4 mg/L 0.0974358974358974 +DTXSID7045865 Css 3compartmentss Human 95% 5.545 mg/L 21.18 mg/L 0.26180358829084 +DTXSID7045867 Css 3compartmentss Human 95% 15.51 mg/L 28.01 mg/L 0.553730810424848 +DTXSID7045940 Css 3compartmentss Human 95% 0.4382 mg/L 4.073 mg/L 0.107586545543825 +DTXSID7045944 Css 3compartmentss Human 95% 6.934 mg/L 0.8678 mg/L 7.99032035031113 +DTXSID7045946 Css 3compartmentss Human 95% 11.68 mg/L 17.72 mg/L 0.659142212189616 +DTXSID7045948 Css 3compartmentss Human 95% 0.6928 mg/L 0.6695 mg/L 1.03480209111277 +DTXSID7045992 Css 3compartmentss Human 95% 7.287 mg/L 0.4245 mg/L 17.1660777385159 +DTXSID7045998 Css 3compartmentss Human 95% 2.715 mg/L 8.053 mg/L 0.337141437973426 +DTXSID7046041 Css 3compartmentss Human 95% 1.147 mg/L 0.9966 mg/L 1.15091310455549 +DTXSID7046045 Css 3compartmentss Human 95% 7.042 mg/L 1.116 mg/L 6.31003584229391 +DTXSID7046047 Css 3compartmentss Human 95% 0.5298 mg/L 3.284 mg/L 0.161327649208283 +DTXSID7046091 Css 3compartmentss Human 95% 4.062 mg/L 4.589 mg/L 0.885160165613423 +DTXSID7046093 Css 3compartmentss Human 95% 5.883 mg/L 6.079 mg/L 0.967757854910347 +DTXSID7046095 Css 3compartmentss Human 95% 4.74 mg/L 0.02489 mg/L 190.437926878264 +DTXSID7046097 Css 3compartmentss Human 95% 7.594 mg/L 5.704 mg/L 1.33134642356241 +DTXSID7046099 Css 3compartmentss Human 95% 0.866 mg/L 0.1393 mg/L 6.21679827709978 +DTXSID7046120 Css 3compartmentss Human 95% 5.449 mg/L 3.137 mg/L 1.73700988205292 +DTXSID7046122 Css 3compartmentss Human 95% 5.589 mg/L 219.1 mg/L 0.0255089000456413 +DTXSID7046126 Css 3compartmentss Human 95% 3.381 mg/L 3.221 mg/L 1.04967401428128 +DTXSID7046128 Css 3compartmentss Human 95% 0.6253 mg/L 1.398 mg/L 0.447281831187411 +DTXSID7046170 Css 3compartmentss Human 95% 6.547 mg/L 7.208 mg/L 0.908296337402886 +DTXSID7046172 Css 3compartmentss Human 95% 6.356 mg/L 7.468 mg/L 0.851098018211034 +DTXSID7046174 Css 3compartmentss Human 95% 5.362 mg/L 1.682 mg/L 3.18787158145065 +DTXSID7046176 Css 3compartmentss Human 95% 7.945 mg/L 1.286 mg/L 6.17807153965785 +DTXSID7046178 Css 3compartmentss Human 95% 2.787 mg/L 1.261 mg/L 2.2101506740682 +DTXSID7046201 Css 3compartmentss Human 95% 7.936 mg/L 0.6618 mg/L 11.9915382290722 +DTXSID7046205 Css 3compartmentss Human 95% 2.193 mg/L 4.662 mg/L 0.47039897039897 +DTXSID7046207 Css 3compartmentss Human 95% 1.415 mg/L 8.814 mg/L 0.160540049920581 +DTXSID7046251 Css 3compartmentss Human 95% 0.3627 mg/L 6.693 mg/L 0.0541909457642313 +DTXSID7046253 Css 3compartmentss Human 95% 6.535 mg/L 3.366 mg/L 1.94147355912062 +DTXSID7046257 Css 3compartmentss Human 95% 2.073 mg/L 4.225 mg/L 0.490650887573965 +DTXSID7046259 Css 3compartmentss Human 95% 1.196 mg/L 1.045 mg/L 1.1444976076555 +DTXSID7046384 Css 3compartmentss Human 95% 0.9158 mg/L 0.2909 mg/L 3.1481608800275 +DTXSID7046386 Css 3compartmentss Human 95% 6.883 mg/L 11.42 mg/L 0.602714535901926 +DTXSID7046388 Css 3compartmentss Human 95% 2.286 mg/L 4.581 mg/L 0.49901768172888 +DTXSID7046411 Css 3compartmentss Human 95% 0.7994 mg/L 6.828 mg/L 0.117076742823667 +DTXSID7046413 Css 3compartmentss Human 95% 1.704 mg/L 0.2389 mg/L 7.1326915027208 +DTXSID7046415 Css 3compartmentss Human 95% 0.8218 mg/L 0.179 mg/L 4.59106145251397 +DTXSID7046417 Css 3compartmentss Human 95% 1.015 mg/L 4.517 mg/L 0.224706663714855 +DTXSID7046419 Css 3compartmentss Human 95% 0.4189 mg/L 1.793 mg/L 0.233630786391523 +DTXSID7046461 Css 3compartmentss Human 95% 6.26 mg/L 0.4708 mg/L 13.2965165675446 +DTXSID7046463 Css 3compartmentss Human 95% 10.56 mg/L 1.387 mg/L 7.61355443403028 +DTXSID7046465 Css 3compartmentss Human 95% 6.363 mg/L 3.915 mg/L 1.62528735632184 +DTXSID7046467 Css 3compartmentss Human 95% 0.5526 mg/L 0.2444 mg/L 2.26104746317512 +DTXSID7046540 Css 3compartmentss Human 95% 5.235 mg/L 5.756 mg/L 0.90948575399583 +DTXSID7046542 Css 3compartmentss Human 95% 4.488 mg/L 2.66 mg/L 1.68721804511278 +DTXSID7046592 Css 3compartmentss Human 95% 0.923 mg/L 7.329 mg/L 0.125938054304816 +DTXSID7046594 Css 3compartmentss Human 95% 4.731 mg/L 7.654 mg/L 0.618108178730076 +DTXSID7046621 Css 3compartmentss Human 95% 6.478 mg/L 0.8018 mg/L 8.07932152656523 +DTXSID7046623 Css 3compartmentss Human 95% 7.728 mg/L 10.29 mg/L 0.751020408163265 +DTXSID7046627 Css 3compartmentss Human 95% 63.61 mg/L 44.16 mg/L 1.44044384057971 +DTXSID7046673 Css 3compartmentss Human 95% 5.633 mg/L 6.143 mg/L 0.916978674914537 +DTXSID7046675 Css 3compartmentss Human 95% 3.446 mg/L 0.5994 mg/L 5.74908241574908 +DTXSID7046677 Css 3compartmentss Human 95% 1.559 mg/L 0.1662 mg/L 9.38026474127557 +DTXSID7046700 Css 3compartmentss Human 95% 0.8684 mg/L 0.02039 mg/L 42.5895046591466 +DTXSID7046702 Css 3compartmentss Human 95% 8.207 mg/L 12.53 mg/L 0.654988028731046 +DTXSID7046706 Css 3compartmentss Human 95% 5.138 mg/L 5.943 mg/L 0.864546525323911 +DTXSID7046708 Css 3compartmentss Human 95% 0.07388 mg/L 0.09129 mg/L 0.809289078759996 +DTXSID7046752 Css 3compartmentss Human 95% 7.26 mg/L 7.881 mg/L 0.921202893033879 +DTXSID7046754 Css 3compartmentss Human 95% 14.09 mg/L 0.1773 mg/L 79.4698251551043 +DTXSID7046756 Css 3compartmentss Human 95% 8.526 mg/L 0.8044 mg/L 10.5992043759324 +DTXSID7046758 Css 3compartmentss Human 95% 2.04 mg/L 1.573 mg/L 1.29688493324857 +DTXSID7046831 Css 3compartmentss Human 95% 6.397 mg/L 7.122 mg/L 0.898202752035945 +DTXSID7046833 Css 3compartmentss Human 95% 8.878 mg/L NA NA NA +DTXSID7046835 Css 3compartmentss Human 95% 0.4093 mg/L 1.035 mg/L 0.395458937198068 +DTXSID7046837 Css 3compartmentss Human 95% 0.4627 mg/L 0.09191 mg/L 5.03427265803503 +DTXSID7046839 Css 3compartmentss Human 95% 0.3425 mg/L 2.22 mg/L 0.154279279279279 +DTXSID7046881 Css 3compartmentss Human 95% 9.973 mg/L 40.38 mg/L 0.246978702327885 +DTXSID7046883 Css 3compartmentss Human 95% 0.7566 mg/L 4.346 mg/L 0.174091118269673 +DTXSID7046885 Css 3compartmentss Human 95% 6.37 mg/L 3.307 mg/L 1.92621711521016 +DTXSID7046887 Css 3compartmentss Human 95% 6.836 mg/L 0.8937 mg/L 7.64909925030771 +DTXSID7046889 Css 3compartmentss Human 95% 2.841 mg/L 7.747 mg/L 0.366722602297664 +DTXSID7046910 Css 3compartmentss Human 95% 4.01 mg/L 32.1 mg/L 0.124922118380062 +DTXSID7046912 Css 3compartmentss Human 95% 0.3624 mg/L 12.31 mg/L 0.0294394800974817 +DTXSID7046914 Css 3compartmentss Human 95% 0.9303 mg/L 39.25 mg/L 0.0237019108280255 +DTXSID7046966 Css 3compartmentss Human 95% 6.492 mg/L 1.164 mg/L 5.57731958762887 +DTXSID7047065 Css 3compartmentss Human 95% 0.3719 mg/L 0.04877 mg/L 7.62558950174287 +DTXSID7047144 Css 3compartmentss Human 95% 0.2253 mg/L 0.4279 mg/L 0.526524888992755 +DTXSID7047146 Css 3compartmentss Human 95% 21.16 mg/L 5.673 mg/L 3.72994888066279 +DTXSID7047190 Css 3compartmentss Human 95% 1.926 mg/L 60.57 mg/L 0.0317979197622585 +DTXSID7047196 Css 3compartmentss Human 95% 0.3386 mg/L 2.676 mg/L 0.126532137518685 +DTXSID7047271 Css 3compartmentss Human 95% 1.924 mg/L 7.327 mg/L 0.262590418998226 +DTXSID7047277 Css 3compartmentss Human 95% 5.966 mg/L 12.33 mg/L 0.483860502838605 +DTXSID7047279 Css 3compartmentss Human 95% 16.53 mg/L 2.537 mg/L 6.51556957035869 +DTXSID7047304 Css 3compartmentss Human 95% 12.8 mg/L 104.4 mg/L 0.122605363984674 +DTXSID7047306 Css 3compartmentss Human 95% 260.2 mg/L 255.8 mg/L 1.01720093823299 +DTXSID7047308 Css 3compartmentss Human 95% 33.49 mg/L 70.72 mg/L 0.473557692307692 +DTXSID7047354 Css 3compartmentss Human 95% 11.24 mg/L 9.241 mg/L 1.21631858024023 +DTXSID7047356 Css 3compartmentss Human 95% 0.3965 mg/L 1.273 mg/L 0.3114689709348 +DTXSID7047358 Css 3compartmentss Human 95% 1.65 mg/L 1.859 mg/L 0.887573964497041 +DTXSID7047433 Css 3compartmentss Human 95% 6.267 mg/L 7.539 mg/L 0.831277357739753 +DTXSID7047435 Css 3compartmentss Human 95% 0.6659 mg/L 4.662 mg/L 0.142835692835693 +DTXSID7047437 Css 3compartmentss Human 95% 0.969 mg/L 31.17 mg/L 0.0310875842155919 +DTXSID7047487 Css 3compartmentss Human 95% 9.442 mg/L 4.433 mg/L 2.12993458154748 +DTXSID7047510 Css 3compartmentss Human 95% 2.133 mg/L NA NA NA +DTXSID7047518 Css 3compartmentss Human 95% 0.3863 mg/L 1.011 mg/L 0.382096933728981 +DTXSID7047568 Css 3compartmentss Human 95% 2.625 mg/L 2.739 mg/L 0.958378970427163 +DTXSID7047643 Css 3compartmentss Human 95% 0.3646 mg/L 9.345 mg/L 0.0390155163188871 +DTXSID7047645 Css 3compartmentss Human 95% 0.8172 mg/L 0.03324 mg/L 24.5848375451264 +DTXSID7047647 Css 3compartmentss Human 95% 25.65 mg/L 9.029 mg/L 2.84084616236571 +DTXSID7047649 Css 3compartmentss Human 95% 1.192 mg/L 0.05108 mg/L 23.3359436178543 +DTXSID7047693 Css 3compartmentss Human 95% 7.331 mg/L 5.216 mg/L 1.40548312883436 +DTXSID7047697 Css 3compartmentss Human 95% 0.9826 mg/L 0.9789 mg/L 1.00377975278374 +DTXSID7047726 Css 3compartmentss Human 95% 2.246 mg/L 1.118 mg/L 2.00894454382826 +DTXSID7047772 Css 3compartmentss Human 95% 1.265 mg/L 2.484 mg/L 0.509259259259259 +DTXSID7047774 Css 3compartmentss Human 95% 1.733 mg/L 0.2883 mg/L 6.01109954908082 +DTXSID7047776 Css 3compartmentss Human 95% 0.4577 mg/L 0.1064 mg/L 4.30169172932331 +DTXSID7047778 Css 3compartmentss Human 95% 14.33 mg/L 1.803 mg/L 7.94786466999445 +DTXSID7047801 Css 3compartmentss Human 95% 6.537 mg/L 7.552 mg/L 0.865598516949153 +DTXSID7047803 Css 3compartmentss Human 95% 7.07 mg/L 0.5109 mg/L 13.8383245253474 +DTXSID7047807 Css 3compartmentss Human 95% 0.8137 mg/L 0.292 mg/L 2.78664383561644 +DTXSID7047851 Css 3compartmentss Human 95% 0.7015 mg/L 0.7206 mg/L 0.973494310296975 +DTXSID7047857 Css 3compartmentss Human 95% 7.147 mg/L 0.4816 mg/L 14.8401162790698 +DTXSID7047859 Css 3compartmentss Human 95% 0.9051 mg/L 1.897 mg/L 0.477121771217712 +DTXSID7048168 Css 3compartmentss Human 95% 13.27 mg/L 13.76 mg/L 0.964389534883721 +DTXSID7048249 Css 3compartmentss Human 95% 0.7583 mg/L NA NA NA +DTXSID7048291 Css 3compartmentss Human 95% 601.7 mg/L 679.8 mg/L 0.885113268608414 +DTXSID7048295 Css 3compartmentss Human 95% 4.355 mg/L NA NA NA +DTXSID7048320 Css 3compartmentss Human 95% 0.8939 mg/L NA NA NA +DTXSID7048326 Css 3compartmentss Human 95% 9.298 mg/L NA NA NA +DTXSID7048370 Css 3compartmentss Human 95% 0.822 mg/L NA NA NA +DTXSID7048534 Css 3compartmentss Human 95% 0.5755 mg/L NA NA NA +DTXSID7048536 Css 3compartmentss Human 95% 0.8431 mg/L NA NA NA +DTXSID7048580 Css 3compartmentss Human 95% 4.93 mg/L 0.1031 mg/L 47.8176527643065 +DTXSID7048582 Css 3compartmentss Human 95% 1.756 mg/L 0.3965 mg/L 4.42875157629256 +DTXSID7048586 Css 3compartmentss Human 95% 6.386 mg/L 0.04218 mg/L 151.398767188241 +DTXSID7048588 Css 3compartmentss Human 95% 1.158 mg/L 4.918 mg/L 0.235461569743798 +DTXSID7048611 Css 3compartmentss Human 95% 6.94 mg/L 3.911 mg/L 1.7744822296088 +DTXSID7048613 Css 3compartmentss Human 95% 31.08 mg/L 34.56 mg/L 0.899305555555555 +DTXSID7048617 Css 3compartmentss Human 95% 43.59 mg/L 55.75 mg/L 0.781883408071749 +DTXSID7048619 Css 3compartmentss Human 95% 17.4 mg/L 46.4 mg/L 0.375 +DTXSID7048661 Css 3compartmentss Human 95% 1.157 mg/L 6.709 mg/L 0.172454911313161 +DTXSID7048663 Css 3compartmentss Human 95% 11.58 mg/L 7.24 mg/L 1.59944751381215 +DTXSID7048665 Css 3compartmentss Human 95% 29.84 mg/L 30.93 mg/L 0.96475913352732 +DTXSID7048667 Css 3compartmentss Human 95% 0.3305 mg/L 0.2835 mg/L 1.1657848324515 +DTXSID7048669 Css 3compartmentss Human 95% 1.569 mg/L 2.868 mg/L 0.547071129707113 +DTXSID7048740 Css 3compartmentss Human 95% 5.293 mg/L 6.143 mg/L 0.861631124857562 +DTXSID7048742 Css 3compartmentss Human 95% 2.7 mg/L 7.092 mg/L 0.380710659898477 +DTXSID7048746 Css 3compartmentss Human 95% 1.699 mg/L 60.61 mg/L 0.0280316779409338 +DTXSID7048748 Css 3compartmentss Human 95% 0.839 mg/L 0.1217 mg/L 6.89400164338537 +DTXSID7048790 Css 3compartmentss Human 95% 10.31 mg/L 10.21 mg/L 1.00979431929481 +DTXSID7048792 Css 3compartmentss Human 95% 1.216 mg/L 0.1534 mg/L 7.92698826597132 +DTXSID7048794 Css 3compartmentss Human 95% 2.427 mg/L 13.5 mg/L 0.179777777777778 +DTXSID7048796 Css 3compartmentss Human 95% 5.158 mg/L 26.27 mg/L 0.196345641416064 +DTXSID7048798 Css 3compartmentss Human 95% 0.1185 mg/L 0.0197 mg/L 6.01522842639594 +DTXSID7048821 Css 3compartmentss Human 95% 5.739 mg/L 10.02 mg/L 0.572754491017964 +DTXSID7048823 Css 3compartmentss Human 95% 15.76 mg/L 5698 mg/L 0.00276588276588277 +DTXSID7048825 Css 3compartmentss Human 95% 0.6734 mg/L 0.205 mg/L 3.28487804878049 +DTXSID7048827 Css 3compartmentss Human 95% 9.238 mg/L 335.6 mg/L 0.0275268176400477 +DTXSID7048829 Css 3compartmentss Human 95% 1.679 mg/L 0.7063 mg/L 2.37717683703809 +DTXSID7048871 Css 3compartmentss Human 95% 1.231 mg/L 0.6371 mg/L 1.93219274839115 +DTXSID7048873 Css 3compartmentss Human 95% 7.853 mg/L 11.41 mg/L 0.688255915863278 +DTXSID7048875 Css 3compartmentss Human 95% 2.207 mg/L 7.066 mg/L 0.312340786866686 +DTXSID7048877 Css 3compartmentss Human 95% 0.7392 mg/L 2.096 mg/L 0.352671755725191 +DTXSID7048879 Css 3compartmentss Human 95% 6.38 mg/L 0.005636 mg/L 1132.0085166785 +DTXSID7048900 Css 3compartmentss Human 95% 0.3369 mg/L 0.2993 mg/L 1.12562646174407 +DTXSID7048902 Css 3compartmentss Human 95% 0.9581 mg/L 0.5565 mg/L 1.72165318957772 +DTXSID7048904 Css 3compartmentss Human 95% 0.9288 mg/L 0.3727 mg/L 2.49208478669171 +DTXSID7048906 Css 3compartmentss Human 95% 6.488 mg/L 1.732 mg/L 3.7459584295612 +DTXSID7048908 Css 3compartmentss Human 95% 0.8449 mg/L 0.4435 mg/L 1.90507328072153 +DTXSID7048950 Css 3compartmentss Human 95% 4.132 mg/L 14.64 mg/L 0.28224043715847 +DTXSID7048952 Css 3compartmentss Human 95% 0.1134 mg/L 0.1154 mg/L 0.982668977469671 +DTXSID7048956 Css 3compartmentss Human 95% 42.5 mg/L 0.2126 mg/L 199.905926622766 +DTXSID7048958 Css 3compartmentss Human 95% 6.089 mg/L 20.34 mg/L 0.299360865290069 +DTXSID7049001 Css 3compartmentss Human 95% 1.018 mg/L 0.08216 mg/L 12.3904576436222 +DTXSID7049003 Css 3compartmentss Human 95% 0.7622 mg/L 0.2182 mg/L 3.49312557286893 +DTXSID7049005 Css 3compartmentss Human 95% 2.282 mg/L 22.99 mg/L 0.0992605480643758 +DTXSID7049007 Css 3compartmentss Human 95% 19.04 mg/L 11.67 mg/L 1.63153384747215 +DTXSID7049009 Css 3compartmentss Human 95% 11.36 mg/L 28.64 mg/L 0.396648044692737 +DTXSID7049051 Css 3compartmentss Human 95% 1.774 mg/L 4.807 mg/L 0.36904514250052 +DTXSID7049053 Css 3compartmentss Human 95% 0.851 mg/L 0.04943 mg/L 17.2162654258547 +DTXSID7049055 Css 3compartmentss Human 95% 1.532 mg/L 1.629 mg/L 0.940454266421117 +DTXSID7049057 Css 3compartmentss Human 95% 1.217 mg/L 0.4645 mg/L 2.6200215285253 +DTXSID7049059 Css 3compartmentss Human 95% 1.547 mg/L 0.3896 mg/L 3.97073921971253 +DTXSID7049211 Css 3compartmentss Human 95% 14.6 mg/L 9.505 mg/L 1.53603366649132 +DTXSID7049213 Css 3compartmentss Human 95% 7.27 mg/L 16.8 mg/L 0.432738095238095 +DTXSID7049215 Css 3compartmentss Human 95% 0.3079 mg/L 5.345 mg/L 0.0576052385406922 +DTXSID7049261 Css 3compartmentss Human 95% 0.3354 mg/L 2.734 mg/L 0.122677395757132 +DTXSID7049265 Css 3compartmentss Human 95% 3.514 mg/L 0.3968 mg/L 8.85584677419355 +DTXSID7049340 Css 3compartmentss Human 95% 10.7 mg/L 5.472 mg/L 1.95540935672515 +DTXSID7049344 Css 3compartmentss Human 95% 2.882 mg/L 6.991 mg/L 0.412244314118152 +DTXSID7049346 Css 3compartmentss Human 95% 2.633 mg/L 13.03 mg/L 0.202072141212586 +DTXSID7049392 Css 3compartmentss Human 95% 1.908 mg/L 4.743 mg/L 0.402277039848197 +DTXSID7049394 Css 3compartmentss Human 95% 0.559 mg/L 1.894 mg/L 0.295142555438226 +DTXSID7049396 Css 3compartmentss Human 95% 1.498 mg/L NA NA NA +DTXSID7049398 Css 3compartmentss Human 95% 1.234 mg/L 9.107 mg/L 0.135500164708466 +DTXSID7049423 Css 3compartmentss Human 95% 0.4953 mg/L 0.3487 mg/L 1.42041869802122 +DTXSID7049425 Css 3compartmentss Human 95% 4.968 mg/L 5.754 mg/L 0.86339937434828 +DTXSID7049427 Css 3compartmentss Human 95% 12.63 mg/L 143.8 mg/L 0.0878303198887344 +DTXSID7049429 Css 3compartmentss Human 95% 1.708 mg/L 4.031 mg/L 0.42371619945423 +DTXSID7051474 Css 3compartmentss Human 95% 5.511 mg/L 0.2964 mg/L 18.5931174089069 +DTXSID7051557 Css 3compartmentss Human 95% 0.3146 mg/L 1.81 mg/L 0.173812154696133 +DTXSID7051715 Css 3compartmentss Human 95% 4.299 mg/L 0.2896 mg/L 14.8446132596685 +DTXSID7051890 Css 3compartmentss Human 95% 6.453 mg/L NA NA NA +DTXSID7052286 Css 3compartmentss Human 95% 0.6852 mg/L NA NA NA +DTXSID7052288 Css 3compartmentss Human 95% 0.7423 mg/L 6.273 mg/L 0.118332536266539 +DTXSID7052319 Css 3compartmentss Human 95% 1.619 mg/L 1.218 mg/L 1.32922824302135 +DTXSID7052446 Css 3compartmentss Human 95% 0.4542 mg/L 1.433 mg/L 0.316957431960921 +DTXSID7052529 Css 3compartmentss Human 95% 1.582 mg/L 0.6926 mg/L 2.28414669361825 +DTXSID7052571 Css 3compartmentss Human 95% 7.596 mg/L 9.829 mg/L 0.772815138874758 +DTXSID7052573 Css 3compartmentss Human 95% 19.04 mg/L 0.947 mg/L 20.1055966209081 +DTXSID7052575 Css 3compartmentss Human 95% 5.166 mg/L NA NA NA +DTXSID7052577 Css 3compartmentss Human 95% 7.102 mg/L 7.199 mg/L 0.986525906375886 +DTXSID7052602 Css 3compartmentss Human 95% 4.297 mg/L 9.525 mg/L 0.451128608923884 +DTXSID7052606 Css 3compartmentss Human 95% 11.84 mg/L NA NA NA +DTXSID7052860 Css 3compartmentss Human 95% 1.228 mg/L 0.8161 mg/L 1.50471755912266 +DTXSID7057573 Css 3compartmentss Human 95% 4.178 mg/L NA NA NA +DTXSID7057602 Css 3compartmentss Human 95% 0.8802 mg/L 0.4236 mg/L 2.07790368271955 +DTXSID7057604 Css 3compartmentss Human 95% 0.8147 mg/L 2.878 mg/L 0.283078526754691 +DTXSID7057606 Css 3compartmentss Human 95% 6.174 mg/L 4.579 mg/L 1.34832932954794 +DTXSID7057608 Css 3compartmentss Human 95% 1.858 mg/L 1.399 mg/L 1.32809149392423 +DTXSID7057650 Css 3compartmentss Human 95% 1.406 mg/L 1.011 mg/L 1.39070227497527 +DTXSID7057652 Css 3compartmentss Human 95% 2.026 mg/L 0.3725 mg/L 5.43892617449664 +DTXSID7057654 Css 3compartmentss Human 95% 0.5161 mg/L 1.191 mg/L 0.433333333333333 +DTXSID7057656 Css 3compartmentss Human 95% 16.6 mg/L 5.589 mg/L 2.97011987833244 +DTXSID7057658 Css 3compartmentss Human 95% 12.58 mg/L 12.7 mg/L 0.990551181102362 +DTXSID7057731 Css 3compartmentss Human 95% 27.16 mg/L 2.881 mg/L 9.42728219368275 +DTXSID7057733 Css 3compartmentss Human 95% 0.8894 mg/L 2.472 mg/L 0.359789644012945 +DTXSID7057735 Css 3compartmentss Human 95% 5.355 mg/L 0.5085 mg/L 10.5309734513274 +DTXSID7057737 Css 3compartmentss Human 95% 0.4766 mg/L 3.473 mg/L 0.137230060466456 +DTXSID7057739 Css 3compartmentss Human 95% 0.4576 mg/L 0.2414 mg/L 1.89560894780447 +DTXSID7057781 Css 3compartmentss Human 95% 0.2675 mg/L 3.118 mg/L 0.0857921744708146 +DTXSID7057783 Css 3compartmentss Human 95% 4.307 mg/L 5.943 mg/L 0.724718155813562 +DTXSID7057785 Css 3compartmentss Human 95% 5.299 mg/L 2.92 mg/L 1.81472602739726 +DTXSID7057787 Css 3compartmentss Human 95% 2.324 mg/L 0.7986 mg/L 2.91009266215878 +DTXSID7057789 Css 3compartmentss Human 95% 6.307 mg/L 215.9 mg/L 0.0292125984251969 +DTXSID7057810 Css 3compartmentss Human 95% 2.779 mg/L 3.203 mg/L 0.867624102403996 +DTXSID7057812 Css 3compartmentss Human 95% 22.58 mg/L 10.46 mg/L 2.15869980879541 +DTXSID7057816 Css 3compartmentss Human 95% 3.705 mg/L 3.899 mg/L 0.950243652218518 +DTXSID7057818 Css 3compartmentss Human 95% 22.2 mg/L 7.276 mg/L 3.05112699285322 +DTXSID7058626 Css 3compartmentss Human 95% 8.035 mg/L NA NA NA +DTXSID7058705 Css 3compartmentss Human 95% 4.183 mg/L NA NA NA +DTXSID7059224 Css 3compartmentss Human 95% 0.7808 mg/L NA NA NA +DTXSID7059806 Css 3compartmentss Human 95% 1.658 mg/L NA NA NA +DTXSID7062085 Css 3compartmentss Human 95% 5.951 mg/L NA NA NA +DTXSID7062875 Css 3compartmentss Human 95% 0.4933 mg/L NA NA NA +DTXSID7064235 Css 3compartmentss Human 95% 5.565 mg/L NA NA NA +DTXSID7064788 Css 3compartmentss Human 95% 12.49 mg/L NA NA NA +DTXSID7074325 Css 3compartmentss Human 95% 1.137 mg/L NA NA NA +DTXSID7074747 Css 3compartmentss Human 95% 1.121 mg/L NA NA NA +DTXSID70860597 Css 3compartmentss Human 95% 17.17 mg/L NA NA NA +DTXSID70861120 Css 3compartmentss Human 95% 12.09 mg/L NA NA NA +DTXSID70861706 Css 3compartmentss Human 95% 0.3713 mg/L NA NA NA +DTXSID70864232 Css 3compartmentss Human 95% 17.29 mg/L NA NA NA +DTXSID70870176 Css 3compartmentss Human 95% 34.1 mg/L NA NA NA +DTXSID70870252 Css 3compartmentss Human 95% 1.854 mg/L NA NA NA +DTXSID70870934 Css 3compartmentss Human 95% 1.826 mg/L NA NA NA +DTXSID70872933 Css 3compartmentss Human 95% 0.9685 mg/L NA NA NA +DTXSID70873208 Css 3compartmentss Human 95% 5.622 mg/L NA NA NA +DTXSID70873223 Css 3compartmentss Human 95% 3.337 mg/L NA NA NA +DTXSID70873364 Css 3compartmentss Human 95% 0.6171 mg/L NA NA NA +DTXSID70873384 Css 3compartmentss Human 95% 2.933 mg/L NA NA NA +DTXSID70874013 Css 3compartmentss Human 95% 1.029 mg/L NA NA NA +DTXSID70880659 Css 3compartmentss Human 95% 0.6062 mg/L NA NA NA +DTXSID70880715 Css 3compartmentss Human 95% 14.58 mg/L NA NA NA +DTXSID70880811 Css 3compartmentss Human 95% 5.305 mg/L NA NA NA +DTXSID70880836 Css 3compartmentss Human 95% 11.15 mg/L NA NA NA +DTXSID70880856 Css 3compartmentss Human 95% 7.335 mg/L NA NA NA +DTXSID70880912 Css 3compartmentss Human 95% 7.683 mg/L NA NA NA +DTXSID70880917 Css 3compartmentss Human 95% 22.48 mg/L NA NA NA +DTXSID70880937 Css 3compartmentss Human 95% 13.29 mg/L NA NA NA +DTXSID70881202 Css 3compartmentss Human 95% 1.821 mg/L NA NA NA +DTXSID70881242 Css 3compartmentss Human 95% 2.229 mg/L NA NA NA +DTXSID70891503 Css 3compartmentss Human 95% 21.53 mg/L NA NA NA +DTXSID70893769 Css 3compartmentss Human 95% 0.6812 mg/L NA NA NA +DTXSID70904521 Css 3compartmentss Human 95% 18.81 mg/L NA NA NA +DTXSID70931418 Css 3compartmentss Human 95% 0.2314 mg/L NA NA NA +DTXSID801001609 Css 3compartmentss Human 95% 4.653 mg/L NA NA NA +DTXSID801005118 Css 3compartmentss Human 95% 4.126 mg/L NA NA NA +DTXSID801025708 Css 3compartmentss Human 95% 32.16 mg/L NA NA NA +DTXSID801026049 Css 3compartmentss Human 95% 11.07 mg/L NA NA NA +DTXSID801126136 Css 3compartmentss Human 95% 2.408 mg/L NA NA NA +DTXSID801135422 Css 3compartmentss Human 95% 11.28 mg/L NA NA NA +DTXSID801317967 Css 3compartmentss Human 95% 0.3555 mg/L NA NA NA +DTXSID801339341 Css 3compartmentss Human 95% 1.946 mg/L NA NA NA +DTXSID80151807 Css 3compartmentss Human 95% 14.78 mg/L NA NA NA +DTXSID80155022 Css 3compartmentss Human 95% 0.9337 mg/L NA NA NA +DTXSID80161224 Css 3compartmentss Human 95% 3.249 mg/L NA NA NA +DTXSID80162130 Css 3compartmentss Human 95% 13.09 mg/L NA NA NA +DTXSID80162857 Css 3compartmentss Human 95% 1.104 mg/L NA NA NA +DTXSID80164336 Css 3compartmentss Human 95% 143 mg/L NA NA NA +DTXSID80170497 Css 3compartmentss Human 95% 12.63 mg/L NA NA NA +DTXSID80173105 Css 3compartmentss Human 95% 0.9193 mg/L NA NA NA +DTXSID80175220 Css 3compartmentss Human 95% 76.49 mg/L NA NA NA +DTXSID80179460 Css 3compartmentss Human 95% 34.97 mg/L NA NA NA +DTXSID80190615 Css 3compartmentss Human 95% 0.5672 mg/L NA NA NA +DTXSID80191501 Css 3compartmentss Human 95% 13.92 mg/L NA NA NA +DTXSID80196152 Css 3compartmentss Human 95% 1.482 mg/L NA NA NA +DTXSID80197780 Css 3compartmentss Human 95% 6.669 mg/L NA NA NA +DTXSID80198318 Css 3compartmentss Human 95% 7.453 mg/L NA NA NA +DTXSID80198994 Css 3compartmentss Human 95% 0.9587 mg/L NA NA NA +DTXSID80199966 Css 3compartmentss Human 95% 5.858 mg/L NA NA NA +DTXSID8020044 Css 3compartmentss Human 95% 5.416 mg/L 6.516 mg/L 0.831184775936157 +DTXSID8020090 Css 3compartmentss Human 95% 0.3038 mg/L 1.364 mg/L 0.222727272727273 +DTXSID8020092 Css 3compartmentss Human 95% 0.4732 mg/L 0.1685 mg/L 2.80830860534125 +DTXSID8020094 Css 3compartmentss Human 95% 0.4487 mg/L 7.781 mg/L 0.0576661097545303 +DTXSID8020127 Css 3compartmentss Human 95% 0.6494 mg/L 0.8474 mg/L 0.766344111399575 +DTXSID8020129 Css 3compartmentss Human 95% 4.656 mg/L 6.638 mg/L 0.701416089183489 +DTXSID8020175 Css 3compartmentss Human 95% 29.41 mg/L 547.4 mg/L 0.0537267080745342 +DTXSID8020179 Css 3compartmentss Human 95% 5.56 mg/L 0.635 mg/L 8.75590551181102 +DTXSID8020200 Css 3compartmentss Human 95% 5.368 mg/L 6.153 mg/L 0.87241995774419 +DTXSID8020202 Css 3compartmentss Human 95% 4.585 mg/L 1.1 mg/L 4.16818181818182 +DTXSID8020252 Css 3compartmentss Human 95% 6.962 mg/L 4.662 mg/L 1.49335049335049 +DTXSID8020256 Css 3compartmentss Human 95% 0.7069 mg/L NA NA NA +DTXSID8020331 Css 3compartmentss Human 95% 4.984 mg/L 121.6 mg/L 0.0409868421052632 +DTXSID8020337 Css 3compartmentss Human 95% 7.328 mg/L 0.392 mg/L 18.6938775510204 +DTXSID8020381 Css 3compartmentss Human 95% 20.42 mg/L 4.202 mg/L 4.859590671109 +DTXSID8020383 Css 3compartmentss Human 95% 3.227 mg/L 12.95 mg/L 0.249189189189189 +DTXSID8020410 Css 3compartmentss Human 95% 19.72 mg/L 4.782 mg/L 4.12379757423672 +DTXSID8020462 Css 3compartmentss Human 95% 4.613 mg/L 5.575 mg/L 0.827443946188341 +DTXSID8020464 Css 3compartmentss Human 95% 0.4176 mg/L 0.1002 mg/L 4.16766467065868 +DTXSID8020466 Css 3compartmentss Human 95% 7.056 mg/L 0.7879 mg/L 8.95545119939078 +DTXSID8020468 Css 3compartmentss Human 95% 0.6436 mg/L 0.7668 mg/L 0.839332290036515 +DTXSID8020541 Css 3compartmentss Human 95% 7.436 mg/L 9.833 mg/L 0.756229024712702 +DTXSID8020543 Css 3compartmentss Human 95% 0.9776 mg/L 7.165 mg/L 0.136441032798325 +DTXSID8020545 Css 3compartmentss Human 95% 0.8317 mg/L 0.9477 mg/L 0.877598396116915 +DTXSID8020591 Css 3compartmentss Human 95% 0.9193 mg/L 0.7596 mg/L 1.21024223275408 +DTXSID8020593 Css 3compartmentss Human 95% 4.155 mg/L 4.724 mg/L 0.879551227773074 +DTXSID8020597 Css 3compartmentss Human 95% 6.173 mg/L 7.174 mg/L 0.860468357959297 +DTXSID80206109 Css 3compartmentss Human 95% 1.348 mg/L NA NA NA +DTXSID8020620 Css 3compartmentss Human 95% 7.045 mg/L 2.862 mg/L 2.46156533892383 +DTXSID8020624 Css 3compartmentss Human 95% 6.321 mg/L 7.282 mg/L 0.868030760780005 +DTXSID8020626 Css 3compartmentss Human 95% 0.876 mg/L 0.1066 mg/L 8.21763602251407 +DTXSID8020628 Css 3compartmentss Human 95% 1.351 mg/L 1.389 mg/L 0.97264218862491 +DTXSID8020674 Css 3compartmentss Human 95% 2.447 mg/L 2.6 mg/L 0.941153846153846 +DTXSID8020678 Css 3compartmentss Human 95% 2.06 mg/L 32.05 mg/L 0.0642745709828393 +DTXSID8020707 Css 3compartmentss Human 95% 1.289 mg/L 0.5838 mg/L 2.20794792737239 +DTXSID8020709 Css 3compartmentss Human 95% 0.3494 mg/L 11.62 mg/L 0.0300688468158348 +DTXSID8020753 Css 3compartmentss Human 95% 4.462 mg/L 5.172 mg/L 0.862722351121423 +DTXSID8020755 Css 3compartmentss Human 95% 1.873 mg/L 2.087 mg/L 0.897460469573551 +DTXSID8020757 Css 3compartmentss Human 95% 0.3492 mg/L 8.267 mg/L 0.0422402322486997 +DTXSID8020759 Css 3compartmentss Human 95% 0.468 mg/L NA NA NA +DTXSID8020830 Css 3compartmentss Human 95% 45.63 mg/L 51.12 mg/L 0.892605633802817 +DTXSID8020834 Css 3compartmentss Human 95% 5.363 mg/L 6.023 mg/L 0.890420056450274 +DTXSID8020838 Css 3compartmentss Human 95% 8.779 mg/L 5.228 mg/L 1.6792272379495 +DTXSID8020880 Css 3compartmentss Human 95% 0.7241 mg/L 0.28 mg/L 2.58607142857143 +DTXSID8020886 Css 3compartmentss Human 95% 0.9095 mg/L 0.3729 mg/L 2.4389916867793 +DTXSID8020911 Css 3compartmentss Human 95% 17.09 mg/L 367.5 mg/L 0.0465034013605442 +DTXSID8020915 Css 3compartmentss Human 95% 1.6 mg/L 104.7 mg/L 0.0152817574021012 +DTXSID8020917 Css 3compartmentss Human 95% 6.934 mg/L 0.2116 mg/L 32.7693761814745 +DTXSID8020919 Css 3compartmentss Human 95% 11.49 mg/L 1.766 mg/L 6.50622876557191 +DTXSID8020963 Css 3compartmentss Human 95% 0.7299 mg/L 15.17 mg/L 0.0481147000659196 +DTXSID8020965 Css 3compartmentss Human 95% 0.9652 mg/L 6.408 mg/L 0.150624219725343 +DTXSID80209993 Css 3compartmentss Human 95% 10.46 mg/L NA NA NA +DTXSID8021060 Css 3compartmentss Human 95% 6.305 mg/L 2.867 mg/L 2.19916288803627 +DTXSID8021062 Css 3compartmentss Human 95% 2.46 mg/L 2.967 mg/L 0.829120323559151 +DTXSID8021141 Css 3compartmentss Human 95% 6.855 mg/L 0.9068 mg/L 7.55955006616674 +DTXSID8021145 Css 3compartmentss Human 95% 0.6821 mg/L 0.4854 mg/L 1.40523279769262 +DTXSID8021147 Css 3compartmentss Human 95% 0.3653 mg/L 0.4211 mg/L 0.867489907385419 +DTXSID8021191 Css 3compartmentss Human 95% 1.503 mg/L 0.6736 mg/L 2.2312945368171 +DTXSID8021193 Css 3compartmentss Human 95% 0.388 mg/L 0.1891 mg/L 2.05182443151772 +DTXSID8021195 Css 3compartmentss Human 95% 4.888 mg/L NA NA NA +DTXSID8021197 Css 3compartmentss Human 95% 6.456 mg/L 7.376 mg/L 0.87527114967462 +DTXSID8021199 Css 3compartmentss Human 95% 3.86 mg/L 4.022 mg/L 0.95972153157633 +DTXSID8021222 Css 3compartmentss Human 95% 2.205 mg/L 2.31 mg/L 0.954545454545455 +DTXSID8021224 Css 3compartmentss Human 95% 878.8 mg/L 1510 mg/L 0.581986754966887 +DTXSID8021270 Css 3compartmentss Human 95% 26.87 mg/L 46.75 mg/L 0.57475935828877 +DTXSID8021272 Css 3compartmentss Human 95% 0.05631 mg/L 0.06288 mg/L 0.895515267175572 +DTXSID8021278 Css 3compartmentss Human 95% 0.8649 mg/L 5.248 mg/L 0.164805640243902 +DTXSID8021301 Css 3compartmentss Human 95% 3153 mg/L 3270 mg/L 0.964220183486239 +DTXSID8021305 Css 3compartmentss Human 95% 8.735 mg/L 3.266 mg/L 2.67452541334966 +DTXSID8021309 Css 3compartmentss Human 95% 99.59 mg/L 103.3 mg/L 0.964085188770571 +DTXSID8021359 Css 3compartmentss Human 95% 48.65 mg/L 50.28 mg/L 0.9675815433572 +DTXSID8021430 Css 3compartmentss Human 95% 0.3739 mg/L NA NA NA +DTXSID8021480 Css 3compartmentss Human 95% 5.208 mg/L NA NA NA +DTXSID8021484 Css 3compartmentss Human 95% 5.152 mg/L 11.87 mg/L 0.434035383319292 +DTXSID8021488 Css 3compartmentss Human 95% 6.839 mg/L 11.49 mg/L 0.595213228894691 +DTXSID8021515 Css 3compartmentss Human 95% 7.323 mg/L 8.007 mg/L 0.914574747096291 +DTXSID8021517 Css 3compartmentss Human 95% 7.63 mg/L 8.733 mg/L 0.87369746936906 +DTXSID8021519 Css 3compartmentss Human 95% 7.938 mg/L 7.259 mg/L 1.09353905496625 +DTXSID8021561 Css 3compartmentss Human 95% 2.804 mg/L 3.157 mg/L 0.888184985745961 +DTXSID8021563 Css 3compartmentss Human 95% 1.304 mg/L 164.2 mg/L 0.0079415347137637 +DTXSID8021640 Css 3compartmentss Human 95% 7.206 mg/L 2.184 mg/L 3.29945054945055 +DTXSID8021642 Css 3compartmentss Human 95% 0.994 mg/L 454.9 mg/L 0.00218509562541218 +DTXSID8021644 Css 3compartmentss Human 95% 8.14 mg/L 2.548 mg/L 3.19466248037677 +DTXSID8021646 Css 3compartmentss Human 95% 5.848 mg/L 6.657 mg/L 0.878473786991137 +DTXSID8021648 Css 3compartmentss Human 95% 5.228 mg/L 9.204 mg/L 0.568013906996958 +DTXSID8021690 Css 3compartmentss Human 95% 3.84 mg/L 30.98 mg/L 0.123950936087799 +DTXSID8021721 Css 3compartmentss Human 95% 7.415 mg/L 0.443 mg/L 16.7381489841986 +DTXSID8021725 Css 3compartmentss Human 95% 0.9864 mg/L 1.278 mg/L 0.771830985915493 +DTXSID8021729 Css 3compartmentss Human 95% 8.252 mg/L 85.74 mg/L 0.0962444599953347 +DTXSID8021771 Css 3compartmentss Human 95% 16.7 mg/L 2.715 mg/L 6.15101289134438 +DTXSID8021775 Css 3compartmentss Human 95% 1.83 mg/L 4.805 mg/L 0.380853277835588 +DTXSID8021777 Css 3compartmentss Human 95% 4.488 mg/L 7.624 mg/L 0.588667366211962 +DTXSID8021800 Css 3compartmentss Human 95% 11.88 mg/L NA NA NA +DTXSID8021804 Css 3compartmentss Human 95% 0.06683 mg/L 0.0664 mg/L 1.00647590361446 +DTXSID8021808 Css 3compartmentss Human 95% 0.2997 mg/L 0.3022 mg/L 0.991727332892124 +DTXSID80218303 Css 3compartmentss Human 95% 0.9685 mg/L NA NA NA +DTXSID8021856 Css 3compartmentss Human 95% 2.511 mg/L 2.58 mg/L 0.973255813953488 +DTXSID8021931 Css 3compartmentss Human 95% 0.3631 mg/L 8.031 mg/L 0.0452123023284771 +DTXSID8021937 Css 3compartmentss Human 95% 0.7125 mg/L 12.84 mg/L 0.0554906542056075 +DTXSID8022036 Css 3compartmentss Human 95% 0.7141 mg/L NA NA NA +DTXSID8022080 Css 3compartmentss Human 95% 369.9 mg/L 432.6 mg/L 0.85506241331484 +DTXSID8022082 Css 3compartmentss Human 95% 0.4145 mg/L 3.28 mg/L 0.126371951219512 +DTXSID8022084 Css 3compartmentss Human 95% 0.8678 mg/L 1.508 mg/L 0.575464190981432 +DTXSID8022086 Css 3compartmentss Human 95% 0.3665 mg/L 8.044 mg/L 0.0455619094977623 +DTXSID8022111 Css 3compartmentss Human 95% 4.28 mg/L 4.611 mg/L 0.928215137714162 +DTXSID8022117 Css 3compartmentss Human 95% 7.214 mg/L 0.07108 mg/L 101.491277433877 +DTXSID8022161 Css 3compartmentss Human 95% 59.39 mg/L 68.99 mg/L 0.860849398463545 +DTXSID8022246 Css 3compartmentss Human 95% 8.196 mg/L 1.444 mg/L 5.67590027700831 +DTXSID8022292 Css 3compartmentss Human 95% 20.33 mg/L 19.46 mg/L 1.04470709146968 +DTXSID80222945 Css 3compartmentss Human 95% 12.25 mg/L NA NA NA +DTXSID8022325 Css 3compartmentss Human 95% 5.005 mg/L 2.507 mg/L 1.99641005185481 +DTXSID8022329 Css 3compartmentss Human 95% 2.211 mg/L 5.303 mg/L 0.416933811050349 +DTXSID80223659 Css 3compartmentss Human 95% 19.22 mg/L NA NA NA +DTXSID8022371 Css 3compartmentss Human 95% 3.438 mg/L 3.426 mg/L 1.00350262697023 +DTXSID8022377 Css 3compartmentss Human 95% 10.24 mg/L 10.15 mg/L 1.00886699507389 +DTXSID8022404 Css 3compartmentss Human 95% 14.59 mg/L 0.868 mg/L 16.8087557603687 +DTXSID8022406 Css 3compartmentss Human 95% 6.887 mg/L 7.211 mg/L 0.955068645125503 +DTXSID8022408 Css 3compartmentss Human 95% 31.38 mg/L 11.19 mg/L 2.80428954423593 +DTXSID8022585 Css 3compartmentss Human 95% 3.573 mg/L 2.575 mg/L 1.38757281553398 +DTXSID8022589 Css 3compartmentss Human 95% 3.969 mg/L 4.198 mg/L 0.945450214387804 +DTXSID8022610 Css 3compartmentss Human 95% 0.8591 mg/L 0.7119 mg/L 1.20677061385026 +DTXSID8022614 Css 3compartmentss Human 95% 4.474 mg/L 26.18 mg/L 0.170893812070283 +DTXSID8022741 Css 3compartmentss Human 95% 7.319 mg/L 1.079 mg/L 6.78313253012048 +DTXSID8022743 Css 3compartmentss Human 95% 12.51 mg/L 0.7585 mg/L 16.493078444298 +DTXSID8022747 Css 3compartmentss Human 95% 2.588 mg/L 1.871 mg/L 1.38321753073223 +DTXSID8022749 Css 3compartmentss Human 95% 4.624 mg/L 7.436 mg/L 0.621839698762776 +DTXSID8022822 Css 3compartmentss Human 95% 9.389 mg/L 37.07 mg/L 0.253277582951173 +DTXSID8022824 Css 3compartmentss Human 95% 0.3985 mg/L 0.8137 mg/L 0.489738232763918 +DTXSID8022826 Css 3compartmentss Human 95% 4.167 mg/L NA NA NA +DTXSID8022828 Css 3compartmentss Human 95% 2.604 mg/L 2.692 mg/L 0.967310549777117 +DTXSID8022870 Css 3compartmentss Human 95% 4.337 mg/L 5.154 mg/L 0.841482343810632 +DTXSID8022872 Css 3compartmentss Human 95% 0.5822 mg/L 4.183 mg/L 0.139182404972508 +DTXSID8022901 Css 3compartmentss Human 95% 0.95 mg/L 5.788 mg/L 0.164132688320663 +DTXSID8022907 Css 3compartmentss Human 95% 0.2031 mg/L NA NA NA +DTXSID8022955 Css 3compartmentss Human 95% 5.392 mg/L 12.01 mg/L 0.448959200666112 +DTXSID8022959 Css 3compartmentss Human 95% 1.513 mg/L 3.267 mg/L 0.463116008570554 +DTXSID8023000 Css 3compartmentss Human 95% 20.61 mg/L 17.58 mg/L 1.17235494880546 +DTXSID8023004 Css 3compartmentss Human 95% 18.75 mg/L NA NA NA +DTXSID8023006 Css 3compartmentss Human 95% 10.27 mg/L NA NA NA +DTXSID8023050 Css 3compartmentss Human 95% 33.15 mg/L 493.9 mg/L 0.0671188499696295 +DTXSID8023054 Css 3compartmentss Human 95% 0.7475 mg/L 0.1026 mg/L 7.28557504873294 +DTXSID8023056 Css 3compartmentss Human 95% 14.07 mg/L NA NA NA +DTXSID8023133 Css 3compartmentss Human 95% 0.495 mg/L NA NA NA +DTXSID8023135 Css 3compartmentss Human 95% 0.2324 mg/L NA NA NA +DTXSID8023137 Css 3compartmentss Human 95% 1.026 mg/L 1.675 mg/L 0.612537313432836 +DTXSID8023181 Css 3compartmentss Human 95% 10.61 mg/L 0.2824 mg/L 37.570821529745 +DTXSID8023183 Css 3compartmentss Human 95% 11.31 mg/L 0.006254 mg/L 1808.44259673809 +DTXSID8023185 Css 3compartmentss Human 95% 5.049 mg/L 5.505 mg/L 0.91716621253406 +DTXSID8023187 Css 3compartmentss Human 95% 0.3806 mg/L 0.8801 mg/L 0.432450857857062 +DTXSID8023189 Css 3compartmentss Human 95% 39.85 mg/L NA NA NA +DTXSID8023214 Css 3compartmentss Human 95% 11900 mg/L 13790 mg/L 0.862944162436548 +DTXSID8023216 Css 3compartmentss Human 95% 427.2 mg/L 997.8 mg/L 0.428141912206855 +DTXSID8023260 Css 3compartmentss Human 95% 0.4312 mg/L 2.053 mg/L 0.210034096444228 +DTXSID8023262 Css 3compartmentss Human 95% 12.12 mg/L 39.17 mg/L 0.309420474853204 +DTXSID8023343 Css 3compartmentss Human 95% 1.544 mg/L NA NA NA +DTXSID8023345 Css 3compartmentss Human 95% 0.8209 mg/L 1.019 mg/L 0.805593719332679 +DTXSID8023347 Css 3compartmentss Human 95% 0.5853 mg/L 1.14 mg/L 0.513421052631579 +DTXSID8023349 Css 3compartmentss Human 95% 0.08048 mg/L 0.02605 mg/L 3.089443378119 +DTXSID8023391 Css 3compartmentss Human 95% 15.08 mg/L NA NA NA +DTXSID8023393 Css 3compartmentss Human 95% 10.73 mg/L 17.34 mg/L 0.618800461361015 +DTXSID8023395 Css 3compartmentss Human 95% 0.3879 mg/L 0.9667 mg/L 0.401262025447398 +DTXSID8023397 Css 3compartmentss Human 95% 8.012 mg/L NA NA NA +DTXSID8023422 Css 3compartmentss Human 95% 14.3 mg/L 13.16 mg/L 1.08662613981763 +DTXSID8023426 Css 3compartmentss Human 95% 0.7774 mg/L 0.7903 mg/L 0.983677084651398 +DTXSID80234280 Css 3compartmentss Human 95% 1.022 mg/L NA NA NA +DTXSID8023470 Css 3compartmentss Human 95% 4.245 mg/L 27.18 mg/L 0.156181015452539 +DTXSID8023472 Css 3compartmentss Human 95% 9.078e-05 mg/L 0.01775 mg/L 0.0051143661971831 +DTXSID8023474 Css 3compartmentss Human 95% 3.928 mg/L 0.6337 mg/L 6.19851664825627 +DTXSID8023476 Css 3compartmentss Human 95% 1.235 mg/L 1.727 mg/L 0.715112912565142 +DTXSID8023505 Css 3compartmentss Human 95% 4.147 mg/L 1.782 mg/L 2.32716049382716 +DTXSID8023509 Css 3compartmentss Human 95% 0.8183 mg/L NA NA NA +DTXSID8023551 Css 3compartmentss Human 95% 0.8766 mg/L 23.63 mg/L 0.0370969107067287 +DTXSID8023557 Css 3compartmentss Human 95% 2.88 mg/L 5.533 mg/L 0.520513283932767 +DTXSID80235590 Css 3compartmentss Human 95% 3.817 mg/L NA NA NA +DTXSID8023630 Css 3compartmentss Human 95% 8.557 mg/L 7.935 mg/L 1.07838689350977 +DTXSID8023632 Css 3compartmentss Human 95% 6.091 mg/L 7.149 mg/L 0.85200727374458 +DTXSID8023634 Css 3compartmentss Human 95% 4.225 mg/L NA NA NA +DTXSID8023636 Css 3compartmentss Human 95% 14.21 mg/L 60.66 mg/L 0.234256511704583 +DTXSID8023638 Css 3compartmentss Human 95% 65 mg/L 47.02 mg/L 1.38239047213952 +DTXSID8023680 Css 3compartmentss Human 95% 5.063 mg/L 5.515 mg/L 0.91804170444243 +DTXSID8023688 Css 3compartmentss Human 95% 6.584 mg/L 6.801 mg/L 0.96809292751066 +DTXSID8023713 Css 3compartmentss Human 95% 1.014 mg/L 0.004187 mg/L 242.178170527824 +DTXSID8023715 Css 3compartmentss Human 95% 1.862 mg/L 2.828 mg/L 0.658415841584158 +DTXSID8023719 Css 3compartmentss Human 95% 117.1 mg/L 111.9 mg/L 1.04647006255585 +DTXSID80237650 Css 3compartmentss Human 95% 4.898 mg/L NA NA NA +DTXSID8023846 Css 3compartmentss Human 95% 5.272 mg/L 5.705 mg/L 0.92410166520596 +DTXSID8023848 Css 3compartmentss Human 95% 0.3361 mg/L 0.4573 mg/L 0.734966105401268 +DTXSID80238485 Css 3compartmentss Human 95% 0.4517 mg/L NA NA NA +DTXSID80238521 Css 3compartmentss Human 95% 11.33 mg/L NA NA NA +DTXSID8023890 Css 3compartmentss Human 95% 1.388 mg/L 1.337 mg/L 1.03814510097233 +DTXSID8023892 Css 3compartmentss Human 95% 32.12 mg/L 35.63 mg/L 0.901487510524838 +DTXSID8024072 Css 3compartmentss Human 95% 8.632 mg/L 16.06 mg/L 0.537484433374844 +DTXSID8024101 Css 3compartmentss Human 95% 5.884 mg/L 9.716 mg/L 0.60559901193907 +DTXSID8024107 Css 3compartmentss Human 95% 6.098 mg/L 6.375 mg/L 0.956549019607843 +DTXSID8024109 Css 3compartmentss Human 95% 19.12 mg/L 19.92 mg/L 0.959839357429719 +DTXSID8024151 Css 3compartmentss Human 95% 184.7 mg/L 226.4 mg/L 0.815812720848056 +DTXSID8024153 Css 3compartmentss Human 95% 7.943 mg/L 6.574 mg/L 1.20824459993915 +DTXSID8024159 Css 3compartmentss Human 95% 6.081 mg/L 5.946 mg/L 1.02270433905146 +DTXSID8024234 Css 3compartmentss Human 95% 1.65 mg/L 1.762 mg/L 0.936435868331441 +DTXSID8024238 Css 3compartmentss Human 95% 59.24 mg/L 68.35 mg/L 0.866715435259693 +DTXSID8024280 Css 3compartmentss Human 95% 6.082 mg/L 6.072 mg/L 1.00164690382082 +DTXSID8024284 Css 3compartmentss Human 95% 8.502 mg/L 5.188 mg/L 1.63878180416345 +DTXSID8024286 Css 3compartmentss Human 95% 6.169 mg/L 7.103 mg/L 0.868506264958468 +DTXSID8024311 Css 3compartmentss Human 95% 7.583 mg/L 8.864 mg/L 0.85548285198556 +DTXSID8024315 Css 3compartmentss Human 95% 3.687 mg/L 3.757 mg/L 0.981368112856002 +DTXSID8024317 Css 3compartmentss Human 95% 12.16 mg/L 12.37 mg/L 0.983023443815683 +DTXSID8024498 Css 3compartmentss Human 95% 0.3541 mg/L 1.677 mg/L 0.211150864639237 +DTXSID8024523 Css 3compartmentss Human 95% 0.9447 mg/L 0.9855 mg/L 0.958599695585997 +DTXSID8024529 Css 3compartmentss Human 95% 0.3423 mg/L 0.2811 mg/L 1.21771611526147 +DTXSID8024573 Css 3compartmentss Human 95% 0.4327 mg/L 2.846 mg/L 0.152037947997189 +DTXSID8024602 Css 3compartmentss Human 95% 7.995 mg/L 0.002674 mg/L 2989.90276738968 +DTXSID8024608 Css 3compartmentss Human 95% 1.236 mg/L 1.314 mg/L 0.940639269406393 +DTXSID8024652 Css 3compartmentss Human 95% 7.14 mg/L 3.494 mg/L 2.04350314825415 +DTXSID8024733 Css 3compartmentss Human 95% 0.4277 mg/L 0.5605 mg/L 0.76306868867083 +DTXSID8024781 Css 3compartmentss Human 95% 62.7 mg/L NA NA NA +DTXSID8024787 Css 3compartmentss Human 95% 1.64 mg/L 13.82 mg/L 0.118668596237337 +DTXSID8024810 Css 3compartmentss Human 95% 0.9686 mg/L NA NA NA +DTXSID8024862 Css 3compartmentss Human 95% 0.9392 mg/L 0.3554 mg/L 2.64265616207091 +DTXSID8024864 Css 3compartmentss Human 95% 4.757 mg/L 5.701 mg/L 0.834415014909665 +DTXSID8024866 Css 3compartmentss Human 95% 15.74 mg/L 28.2 mg/L 0.558156028368794 +DTXSID8024993 Css 3compartmentss Human 95% 7.605 mg/L 7.836 mg/L 0.97052067381317 +DTXSID8024997 Css 3compartmentss Human 95% 4.454 mg/L 7.398 mg/L 0.602054609353879 +DTXSID8024999 Css 3compartmentss Human 95% 2.361 mg/L 2.426 mg/L 0.97320692497939 +DTXSID8025040 Css 3compartmentss Human 95% 4.957 mg/L 9.447 mg/L 0.524716841325289 +DTXSID8025046 Css 3compartmentss Human 95% 0.5314 mg/L 0.02339 mg/L 22.7191107310817 +DTXSID8025094 Css 3compartmentss Human 95% 0.4292 mg/L 0.04175 mg/L 10.2802395209581 +DTXSID8025096 Css 3compartmentss Human 95% 0.362 mg/L 5.896 mg/L 0.0613975576662144 +DTXSID8025258 Css 3compartmentss Human 95% 3.725 mg/L 0.1708 mg/L 21.8091334894614 +DTXSID8025331 Css 3compartmentss Human 95% 2.805 mg/L 7.675 mg/L 0.365472312703583 +DTXSID8025337 Css 3compartmentss Human 95% 7.47 mg/L 8.803 mg/L 0.848574349653527 +DTXSID8025464 Css 3compartmentss Human 95% 0.3929 mg/L NA NA NA +DTXSID8025591 Css 3compartmentss Human 95% 2.684 mg/L 3.169 mg/L 0.846954875355002 +DTXSID8025593 Css 3compartmentss Human 95% 1.105 mg/L 2.762 mg/L 0.400072411296162 +DTXSID8025595 Css 3compartmentss Human 95% 5.61 mg/L 5.621 mg/L 0.998043052837573 +DTXSID8025599 Css 3compartmentss Human 95% 1.32 mg/L 1.939 mg/L 0.680763280041258 +DTXSID8025628 Css 3compartmentss Human 95% 0.5732 mg/L 0.846 mg/L 0.677541371158393 +DTXSID8025670 Css 3compartmentss Human 95% 0.9736 mg/L 8.413 mg/L 0.115725662664923 +DTXSID8025703 Css 3compartmentss Human 95% 12.38 mg/L NA NA NA +DTXSID8025707 Css 3compartmentss Human 95% 7.99 mg/L 0.2694 mg/L 29.6585003711953 +DTXSID8025751 Css 3compartmentss Human 95% 5.612 mg/L 6.306 mg/L 0.889946083095465 +DTXSID8025759 Css 3compartmentss Human 95% 0.4286 mg/L 5.886 mg/L 0.0728168535507985 +DTXSID8025830 Css 3compartmentss Human 95% 60.61 mg/L NA NA NA +DTXSID8025886 Css 3compartmentss Human 95% 0.8417 mg/L 0.3746 mg/L 2.24693005872931 +DTXSID8025888 Css 3compartmentss Human 95% 0.6746 mg/L 1.032 mg/L 0.653682170542636 +DTXSID8025961 Css 3compartmentss Human 95% 7.161 mg/L 8.338 mg/L 0.858839050131926 +DTXSID8025963 Css 3compartmentss Human 95% 0.3549 mg/L 0.2869 mg/L 1.23701638201464 +DTXSID8025967 Css 3compartmentss Human 95% 6.163 mg/L 7.472 mg/L 0.824812633832976 +DTXSID8026018 Css 3compartmentss Human 95% 2.149 mg/L 85.11 mg/L 0.0252496768887322 +DTXSID8026060 Css 3compartmentss Human 95% 8.371 mg/L 2.171 mg/L 3.85582680792262 +DTXSID8026064 Css 3compartmentss Human 95% 1.461 mg/L 1.688 mg/L 0.865521327014218 +DTXSID8026068 Css 3compartmentss Human 95% 15.09 mg/L 17.71 mg/L 0.852060982495765 +DTXSID8026141 Css 3compartmentss Human 95% 6.741 mg/L 8.057 mg/L 0.836663770634231 +DTXSID8026147 Css 3compartmentss Human 95% 0.9398 mg/L 0.7871 mg/L 1.19400330326515 +DTXSID8026220 Css 3compartmentss Human 95% 0.6437 mg/L 0.2142 mg/L 3.00513538748833 +DTXSID8026224 Css 3compartmentss Human 95% 2.624 mg/L 2.721 mg/L 0.964351341418596 +DTXSID8026228 Css 3compartmentss Human 95% 8.248 mg/L 7.545 mg/L 1.09317428760769 +DTXSID8026270 Css 3compartmentss Human 95% 7.508 mg/L 0.6152 mg/L 12.2041612483745 +DTXSID8026303 Css 3compartmentss Human 95% 178.3 mg/L 285.4 mg/L 0.624737210932025 +DTXSID8026305 Css 3compartmentss Human 95% 0.3861 mg/L 1.051 mg/L 0.367364414843007 +DTXSID8026309 Css 3compartmentss Human 95% 0.3611 mg/L 2.04 mg/L 0.177009803921569 +DTXSID8026432 Css 3compartmentss Human 95% 6.566 mg/L 7.548 mg/L 0.869899311075782 +DTXSID8026436 Css 3compartmentss Human 95% 0.3456 mg/L 0.3799 mg/L 0.909713082390103 +DTXSID8026513 Css 3compartmentss Human 95% 8.719 mg/L 3.24 mg/L 2.69104938271605 +DTXSID8026515 Css 3compartmentss Human 95% 7.197 mg/L 4.882 mg/L 1.47419090536665 +DTXSID8026519 Css 3compartmentss Human 95% 20.66 mg/L 8.006 mg/L 2.58056457656757 +DTXSID8026563 Css 3compartmentss Human 95% 19.23 mg/L 499.7 mg/L 0.0384830898539123 +DTXSID8026698 Css 3compartmentss Human 95% 15.71 mg/L 0.4154 mg/L 37.8189696677901 +DTXSID8026725 Css 3compartmentss Human 95% 17.1 mg/L 516.7 mg/L 0.0330946390555448 +DTXSID8026727 Css 3compartmentss Human 95% 2.798 mg/L 1.659 mg/L 1.68655816757083 +DTXSID8026729 Css 3compartmentss Human 95% 0.3624 mg/L NA NA NA +DTXSID8026773 Css 3compartmentss Human 95% 7.469 mg/L 2.99 mg/L 2.49799331103679 +DTXSID8026775 Css 3compartmentss Human 95% 7.556 mg/L 7.948 mg/L 0.950679416205335 +DTXSID8026981 Css 3compartmentss Human 95% 2.093 mg/L 2.807 mg/L 0.745635910224439 +DTXSID8027032 Css 3compartmentss Human 95% 3.952 mg/L 4.453 mg/L 0.887491578710981 +DTXSID8027034 Css 3compartmentss Human 95% 4.73 mg/L 5.535 mg/L 0.854561878952123 +DTXSID8027036 Css 3compartmentss Human 95% 5.632 mg/L 5.028 mg/L 1.12012728719173 +DTXSID8027084 Css 3compartmentss Human 95% 7.551 mg/L 4.34 mg/L 1.73986175115207 +DTXSID8027086 Css 3compartmentss Human 95% 12.42 mg/L 8510 mg/L 0.00145945945945946 +DTXSID8027113 Css 3compartmentss Human 95% 7.776 mg/L 8.202 mg/L 0.948061448427213 +DTXSID8027163 Css 3compartmentss Human 95% 6.141 mg/L 6.893 mg/L 0.890903815464964 +DTXSID8027169 Css 3compartmentss Human 95% 6.164 mg/L 7.122 mg/L 0.865487222690255 +DTXSID8027240 Css 3compartmentss Human 95% 1.171 mg/L 2.636 mg/L 0.444233687405159 +DTXSID8027246 Css 3compartmentss Human 95% 4.425 mg/L 5.092 mg/L 0.869010212097408 +DTXSID8027294 Css 3compartmentss Human 95% 5.815 mg/L 2.145 mg/L 2.71095571095571 +DTXSID8027321 Css 3compartmentss Human 95% 7.892 mg/L 7.963 mg/L 0.991083762401105 +DTXSID8027323 Css 3compartmentss Human 95% 9.553 mg/L 10.9 mg/L 0.876422018348624 +DTXSID8027400 Css 3compartmentss Human 95% 6.229 mg/L NA NA NA +DTXSID8027402 Css 3compartmentss Human 95% 0.6109 mg/L 0.02561 mg/L 23.8539632955877 +DTXSID8027454 Css 3compartmentss Human 95% 5.158 mg/L 5.595 mg/L 0.9218945487042 +DTXSID8027585 Css 3compartmentss Human 95% 1.086 mg/L 0.4688 mg/L 2.31655290102389 +DTXSID8027589 Css 3compartmentss Human 95% 0.3361 mg/L 7.083 mg/L 0.0474516447832839 +DTXSID8027747 Css 3compartmentss Human 95% 0.4667 mg/L 8.994 mg/L 0.0518901489882144 +DTXSID8027793 Css 3compartmentss Human 95% 6.634 mg/L 8.421 mg/L 0.787792423702648 +DTXSID8027795 Css 3compartmentss Human 95% 69.01 mg/L 76.89 mg/L 0.897515931850696 +DTXSID8027797 Css 3compartmentss Human 95% 19.01 mg/L 4.214 mg/L 4.51115329852871 +DTXSID8027826 Css 3compartmentss Human 95% 5.507 mg/L 3.797 mg/L 1.45035554385041 +DTXSID8027959 Css 3compartmentss Human 95% 0.3951 mg/L 0.7962 mg/L 0.496232102486812 +DTXSID80280666 Css 3compartmentss Human 95% 4.089 mg/L NA NA NA +DTXSID8029072 Css 3compartmentss Human 95% 4.946 mg/L 11.3 mg/L 0.437699115044248 +DTXSID8029105 Css 3compartmentss Human 95% 1.043 mg/L 3.371 mg/L 0.309403737763275 +DTXSID8029153 Css 3compartmentss Human 95% 11.17 mg/L 6.813 mg/L 1.63951269631587 +DTXSID8029157 Css 3compartmentss Human 95% 16.57 mg/L 10.41 mg/L 1.59173871277618 +DTXSID8029159 Css 3compartmentss Human 95% 5.459 mg/L 5.049 mg/L 1.08120419885126 +DTXSID8029230 Css 3compartmentss Human 95% 4.523 mg/L 5.013 mg/L 0.902254139237981 +DTXSID8029232 Css 3compartmentss Human 95% 0.1792 mg/L 3.127 mg/L 0.0573073233130796 +DTXSID8029280 Css 3compartmentss Human 95% 6.664 mg/L 0.4443 mg/L 14.9988746342561 +DTXSID8029282 Css 3compartmentss Human 95% 20.29 mg/L 2.089 mg/L 9.71278123504069 +DTXSID8029286 Css 3compartmentss Human 95% 20.86 mg/L NA NA NA +DTXSID8029575 Css 3compartmentss Human 95% 0.7204 mg/L 23.06 mg/L 0.0312402428447528 +DTXSID8029600 Css 3compartmentss Human 95% 4.74 mg/L 5.561 mg/L 0.852364682611041 +DTXSID8029602 Css 3compartmentss Human 95% 3.607 mg/L 0.138 mg/L 26.1376811594203 +DTXSID8029604 Css 3compartmentss Human 95% 0.8368 mg/L 2.907 mg/L 0.287856897144823 +DTXSID8029606 Css 3compartmentss Human 95% 2.728 mg/L 3.117 mg/L 0.875200513314084 +DTXSID8029868 Css 3compartmentss Human 95% 8781 mg/L 6592 mg/L 1.33206917475728 +DTXSID8030138 Css 3compartmentss Human 95% 2.844 mg/L 3.523 mg/L 0.807266534203803 +DTXSID8030423 Css 3compartmentss Human 95% 24.16 mg/L 11.27 mg/L 2.14374445430346 +DTXSID8030760 Css 3compartmentss Human 95% 111.3 mg/L 0.9326 mg/L 119.343770105083 +DTXSID8031077 Css 3compartmentss Human 95% 61.81 mg/L 62.06 mg/L 0.99597164034805 +DTXSID8031497 Css 3compartmentss Human 95% 5.499 mg/L NA NA NA +DTXSID8031603 Css 3compartmentss Human 95% 0.9839 mg/L 3.779 mg/L 0.260359883567081 +DTXSID8032330 Css 3compartmentss Human 95% 23.27 mg/L NA NA NA +DTXSID8032386 Css 3compartmentss Human 95% 2527 mg/L 2094 mg/L 1.20678127984718 +DTXSID8032417 Css 3compartmentss Human 95% 1.715 mg/L 1.715 mg/L 1 +DTXSID8032463 Css 3compartmentss Human 95% 2.898 mg/L NA NA NA +DTXSID8032544 Css 3compartmentss Human 95% 0.003894 mg/L 0.005088 mg/L 0.765330188679245 +DTXSID8032548 Css 3compartmentss Human 95% 7.519 mg/L 7.215 mg/L 1.04213444213444 +DTXSID8032623 Css 3compartmentss Human 95% 9.4 mg/L 87.56 mg/L 0.107354956601188 +DTXSID8032627 Css 3compartmentss Human 95% 19.65 mg/L 4.752 mg/L 4.13510101010101 +DTXSID8032671 Css 3compartmentss Human 95% 0.9864 mg/L 0.23 mg/L 4.28869565217391 +DTXSID8032673 Css 3compartmentss Human 95% 84.37 mg/L 102 mg/L 0.827156862745098 +DTXSID8032675 Css 3compartmentss Human 95% 21.12 mg/L 5.567 mg/L 3.79378480330519 +DTXSID80332078 Css 3compartmentss Human 95% 0.167 mg/L NA NA NA +DTXSID80332790 Css 3compartmentss Human 95% 8.338 mg/L NA NA NA +DTXSID80333449 Css 3compartmentss Human 95% 1.484 mg/L NA NA NA +DTXSID8033433 Css 3compartmentss Human 95% 1.734 mg/L 10.6 mg/L 0.163584905660377 +DTXSID80334653 Css 3compartmentss Human 95% 6.946 mg/L NA NA NA +DTXSID8033512 Css 3compartmentss Human 95% 1.041 mg/L 3.405 mg/L 0.305726872246696 +DTXSID8033562 Css 3compartmentss Human 95% 19.25 mg/L 20.17 mg/L 0.954387704511651 +DTXSID8033564 Css 3compartmentss Human 95% 1.246 mg/L 12.48 mg/L 0.0998397435897436 +DTXSID8033649 Css 3compartmentss Human 95% 4.977 mg/L 7.851 mg/L 0.633931983186855 +DTXSID8033803 Css 3compartmentss Human 95% 5.872 mg/L 0.3122 mg/L 18.8084561178732 +DTXSID8034087 Css 3compartmentss Human 95% 0.2608 mg/L 0.2873 mg/L 0.907761921336582 +DTXSID8034089 Css 3compartmentss Human 95% 7.12 mg/L NA NA NA +DTXSID8034241 Css 3compartmentss Human 95% 15.95 mg/L 31.11 mg/L 0.512696882031501 +DTXSID8034324 Css 3compartmentss Human 95% 3.643 mg/L 1.161 mg/L 3.13781223083549 +DTXSID8034372 Css 3compartmentss Human 95% 4.413 mg/L 85.72 mg/L 0.0514815678954736 +DTXSID8034376 Css 3compartmentss Human 95% 0.6765 mg/L 9.089 mg/L 0.0744306304323908 +DTXSID8034401 Css 3compartmentss Human 95% 278.7 mg/L 272.1 mg/L 1.02425578831312 +DTXSID8034538 Css 3compartmentss Human 95% 3.571 mg/L 207.7 mg/L 0.0171930669234473 +DTXSID8034580 Css 3compartmentss Human 95% 1.62 mg/L 2.032 mg/L 0.797244094488189 +DTXSID8034586 Css 3compartmentss Human 95% 25.43 mg/L 14.6 mg/L 1.74178082191781 +DTXSID8034588 Css 3compartmentss Human 95% 18.38 mg/L 18.86 mg/L 0.974549310710498 +DTXSID8034665 Css 3compartmentss Human 95% 2.293 mg/L 3.073 mg/L 0.74617637487797 +DTXSID8034669 Css 3compartmentss Human 95% 1.162 mg/L 0.372 mg/L 3.12365591397849 +DTXSID8034792 Css 3compartmentss Human 95% 1.829 mg/L 0.6515 mg/L 2.80736761320031 +DTXSID8034823 Css 3compartmentss Human 95% 2.935 mg/L 6.381 mg/L 0.459959254035418 +DTXSID8034871 Css 3compartmentss Human 95% 0.8268 mg/L 0.8188 mg/L 1.00977039570103 +DTXSID8034875 Css 3compartmentss Human 95% 18.08 mg/L NA NA NA +DTXSID8034877 Css 3compartmentss Human 95% 7.404 mg/L 8.603 mg/L 0.860630012786237 +DTXSID8034956 Css 3compartmentss Human 95% 247.7 mg/L 310 mg/L 0.799032258064516 +DTXSID8035001 Css 3compartmentss Human 95% 2.483 mg/L 36 mg/L 0.0689722222222222 +DTXSID8035180 Css 3compartmentss Human 95% 851.4 mg/L 887.2 mg/L 0.959648331830478 +DTXSID8035184 Css 3compartmentss Human 95% 8.785 mg/L NA NA NA +DTXSID8035186 Css 3compartmentss Human 95% 0.356 mg/L 5.061 mg/L 0.0703418296779293 +DTXSID8035217 Css 3compartmentss Human 95% 0.6049 mg/L 0.6414 mg/L 0.943093233551606 +DTXSID8036732 Css 3compartmentss Human 95% 8.945 mg/L NA NA NA +DTXSID8037128 Css 3compartmentss Human 95% 0.1831 mg/L NA NA NA +DTXSID8037207 Css 3compartmentss Human 95% 6.426 mg/L 7.163 mg/L 0.897110149378752 +DTXSID8037594 Css 3compartmentss Human 95% 10.67 mg/L 11.07 mg/L 0.96386630532972 +DTXSID8037596 Css 3compartmentss Human 95% 1.767 mg/L 2.297 mg/L 0.769264257727471 +DTXSID8037750 Css 3compartmentss Human 95% 14.91 mg/L 3.263 mg/L 4.56941464909592 +DTXSID8037752 Css 3compartmentss Human 95% 51.61 mg/L 10.01 mg/L 5.15584415584416 +DTXSID8037754 Css 3compartmentss Human 95% 4.481 mg/L 1.715 mg/L 2.61282798833819 +DTXSID8037756 Css 3compartmentss Human 95% 0.6059 mg/L 1.273 mg/L 0.475962293794187 +DTXSID80379721 Css 3compartmentss Human 95% 5.625 mg/L NA NA NA +DTXSID8038770 Css 3compartmentss Human 95% 8.595 mg/L 9.805 mg/L 0.876593574706782 +DTXSID8038801 Css 3compartmentss Human 95% 10.07 mg/L 6.501 mg/L 1.54899246269805 +DTXSID8038855 Css 3compartmentss Human 95% 3.688 mg/L NA NA NA +DTXSID8038857 Css 3compartmentss Human 95% 1.313 mg/L 4.947 mg/L 0.265413381847584 +DTXSID8039241 Css 3compartmentss Human 95% 0.4845 mg/L 0.8849 mg/L 0.547519493728105 +DTXSID8040147 Css 3compartmentss Human 95% 0.9781 mg/L 0.7015 mg/L 1.39429793300071 +DTXSID8040222 Css 3compartmentss Human 95% 1322 mg/L 1414 mg/L 0.934936350777935 +DTXSID8040270 Css 3compartmentss Human 95% 7.469 mg/L 9.489 mg/L 0.78712193065655 +DTXSID8040274 Css 3compartmentss Human 95% 19.53 mg/L 9.01 mg/L 2.16759156492786 +DTXSID8040278 Css 3compartmentss Human 95% 7.563 mg/L 7.377 mg/L 1.02521350142334 +DTXSID8040436 Css 3compartmentss Human 95% 4.672 mg/L 9.815 mg/L 0.476006113092206 +DTXSID8040438 Css 3compartmentss Human 95% 2.999 mg/L 2.315 mg/L 1.29546436285097 +DTXSID8040484 Css 3compartmentss Human 95% 8.017 mg/L 0.4783 mg/L 16.7614467907171 +DTXSID8040640 Css 3compartmentss Human 95% 0.6102 mg/L NA NA NA +DTXSID8040694 Css 3compartmentss Human 95% 0.09981 mg/L NA NA NA +DTXSID8040698 Css 3compartmentss Human 95% 4.688 mg/L 1.783 mg/L 2.62927650028043 +DTXSID8040723 Css 3compartmentss Human 95% 16.26 mg/L 15.52 mg/L 1.04768041237113 +DTXSID8040727 Css 3compartmentss Human 95% 6.559 mg/L 4.815 mg/L 1.36220145379024 +DTXSID8040779 Css 3compartmentss Human 95% 3.967 mg/L 12.76 mg/L 0.3108934169279 +DTXSID8040800 Css 3compartmentss Human 95% 6.374 mg/L 7.415 mg/L 0.859608900876601 +DTXSID8041032 Css 3compartmentss Human 95% 1.725 mg/L 0.04572 mg/L 37.7296587926509 +DTXSID8041034 Css 3compartmentss Human 95% 10.43 mg/L 0.4315 mg/L 24.1714947856315 +DTXSID8041080 Css 3compartmentss Human 95% 1.024 mg/L 1.088 mg/L 0.941176470588235 +DTXSID8041115 Css 3compartmentss Human 95% 1.562 mg/L 0.9556 mg/L 1.63457513604018 +DTXSID8041117 Css 3compartmentss Human 95% 16.42 mg/L 0.04705 mg/L 348.990435706695 +DTXSID8041246 Css 3compartmentss Human 95% 4.87 mg/L 5.588 mg/L 0.871510379384395 +DTXSID8041248 Css 3compartmentss Human 95% 12.79 mg/L 8.794 mg/L 1.45440072776893 +DTXSID8041298 Css 3compartmentss Human 95% 7.179 mg/L 5.711 mg/L 1.25704780248643 +DTXSID8041321 Css 3compartmentss Human 95% 4.205 mg/L 5.014 mg/L 0.838651775029916 +DTXSID8041327 Css 3compartmentss Human 95% 4.333 mg/L 7.79 mg/L 0.556225930680359 +DTXSID8041329 Css 3compartmentss Human 95% 20.44 mg/L 37.98 mg/L 0.538177988414955 +DTXSID8041371 Css 3compartmentss Human 95% 6.924 mg/L 7.073 mg/L 0.978933974268344 +DTXSID8041373 Css 3compartmentss Human 95% 8.94 mg/L 9.528 mg/L 0.938287153652393 +DTXSID8041379 Css 3compartmentss Human 95% 20.9 mg/L 13.61 mg/L 1.5356355620867 +DTXSID8041400 Css 3compartmentss Human 95% 0.4116 mg/L 7.842 mg/L 0.052486610558531 +DTXSID8041404 Css 3compartmentss Human 95% 2.961 mg/L 4.299 mg/L 0.688764829030007 +DTXSID8041452 Css 3compartmentss Human 95% 8.513 mg/L 5.475 mg/L 1.55488584474886 +DTXSID80415219 Css 3compartmentss Human 95% 9.962 mg/L NA NA NA +DTXSID8041610 Css 3compartmentss Human 95% 5.195 mg/L 5.642 mg/L 0.920772775611485 +DTXSID8041743 Css 3compartmentss Human 95% 40.44 mg/L 38.43 mg/L 1.05230288836846 +DTXSID8041745 Css 3compartmentss Human 95% 7.376 mg/L 9.413 mg/L 0.783597152873685 +DTXSID8041793 Css 3compartmentss Human 95% 1.316 mg/L 137.7 mg/L 0.00955700798838054 +DTXSID8041797 Css 3compartmentss Human 95% 8.81 mg/L 297.3 mg/L 0.0296333669693912 +DTXSID8041799 Css 3compartmentss Human 95% 4.921 mg/L 247.1 mg/L 0.0199150141643059 +DTXSID8041828 Css 3compartmentss Human 95% 2.745 mg/L 1.049 mg/L 2.61677788369876 +DTXSID8041901 Css 3compartmentss Human 95% 0.6752 mg/L 3.336 mg/L 0.202398081534772 +DTXSID8041951 Css 3compartmentss Human 95% 2.217 mg/L 15.79 mg/L 0.140405319822673 +DTXSID8041955 Css 3compartmentss Human 95% 3.435 mg/L 4.132 mg/L 0.831316553727009 +DTXSID8041957 Css 3compartmentss Human 95% 7.314 mg/L 0.581 mg/L 12.5886402753873 +DTXSID8042002 Css 3compartmentss Human 95% 6.675 mg/L 7.179 mg/L 0.929795236105307 +DTXSID8042137 Css 3compartmentss Human 95% 2.861 mg/L 5.913 mg/L 0.483849145949603 +DTXSID8042181 Css 3compartmentss Human 95% 2.843 mg/L 3.178 mg/L 0.894587791063562 +DTXSID8042187 Css 3compartmentss Human 95% 0.9374 mg/L 0.5643 mg/L 1.66117313485735 +DTXSID8042210 Css 3compartmentss Human 95% 3.439 mg/L 4.038 mg/L 0.851659237246161 +DTXSID8042260 Css 3compartmentss Human 95% 6.068 mg/L NA NA NA +DTXSID8042264 Css 3compartmentss Human 95% 0.6807 mg/L 12.67 mg/L 0.0537253354380426 +DTXSID8042349 Css 3compartmentss Human 95% 21.99 mg/L 4.88 mg/L 4.50614754098361 +DTXSID8042399 Css 3compartmentss Human 95% 9.104 mg/L 85.6 mg/L 0.106355140186916 +DTXSID8042422 Css 3compartmentss Human 95% 0.369 mg/L 0.7369 mg/L 0.500746369928077 +DTXSID8042424 Css 3compartmentss Human 95% 522.2 mg/L 544.2 mg/L 0.9595736861448 +DTXSID8042426 Css 3compartmentss Human 95% 5.002 mg/L 5.773 mg/L 0.866447254460419 +DTXSID8042478 Css 3compartmentss Human 95% 8.117 mg/L 19.66 mg/L 0.412868769074263 +DTXSID8042503 Css 3compartmentss Human 95% 1.76 mg/L 2.726 mg/L 0.645634629493764 +DTXSID8042507 Css 3compartmentss Human 95% 0.3959 mg/L 4.296 mg/L 0.0921554934823091 +DTXSID8042509 Css 3compartmentss Human 95% 2.481 mg/L 24.8 mg/L 0.100040322580645 +DTXSID8042559 Css 3compartmentss Human 95% 5.601 mg/L 0.7245 mg/L 7.73084886128364 +DTXSID8042632 Css 3compartmentss Human 95% 1.297 mg/L 2.397 mg/L 0.541093032957864 +DTXSID80436500 Css 3compartmentss Human 95% 5.088 mg/L NA NA NA +DTXSID80437072 Css 3compartmentss Human 95% 243.6 mg/L NA NA NA +DTXSID8043814 Css 3compartmentss Human 95% 8.137 mg/L 96.04 mg/L 0.0847251145356102 +DTXSID8043941 Css 3compartmentss Human 95% 5.939 mg/L 5.201 mg/L 1.14189578927129 +DTXSID8044123 Css 3compartmentss Human 95% 121.4 mg/L NA NA NA +DTXSID8044200 Css 3compartmentss Human 95% 8.605 mg/L 9.288 mg/L 0.926464254952627 +DTXSID8044204 Css 3compartmentss Human 95% 6.095 mg/L 1.211 mg/L 5.03303055326177 +DTXSID8044206 Css 3compartmentss Human 95% 14.71 mg/L 43.78 mg/L 0.33599817268159 +DTXSID8044208 Css 3compartmentss Human 95% 1.546 mg/L 4.811 mg/L 0.321346913323633 +DTXSID8044252 Css 3compartmentss Human 95% 7.143 mg/L 8.502 mg/L 0.84015525758645 +DTXSID8044381 Css 3compartmentss Human 95% 1.775 mg/L 12.54 mg/L 0.141547049441786 +DTXSID8044385 Css 3compartmentss Human 95% 0.8506 mg/L 1.24 mg/L 0.685967741935484 +DTXSID8044389 Css 3compartmentss Human 95% 5.279 mg/L 5.682 mg/L 0.929074269623372 +DTXSID8044410 Css 3compartmentss Human 95% 5.04 mg/L 1.504 mg/L 3.35106382978723 +DTXSID8044412 Css 3compartmentss Human 95% 1.158 mg/L 5.753 mg/L 0.201286285416305 +DTXSID8044414 Css 3compartmentss Human 95% 0.9998 mg/L 27.52 mg/L 0.0363299418604651 +DTXSID8044416 Css 3compartmentss Human 95% 4.876 mg/L 5.561 mg/L 0.876820715698615 +DTXSID8044464 Css 3compartmentss Human 95% 7.391 mg/L 30.56 mg/L 0.241852094240838 +DTXSID8044466 Css 3compartmentss Human 95% 14.25 mg/L 8.787 mg/L 1.62171389552748 +DTXSID8044543 Css 3compartmentss Human 95% 20.04 mg/L 2.421 mg/L 8.27757125154895 +DTXSID8044591 Css 3compartmentss Human 95% 1.076 mg/L 0.7429 mg/L 1.44837797819357 +DTXSID8044593 Css 3compartmentss Human 95% 0.544 mg/L 2.73 mg/L 0.199267399267399 +DTXSID8044595 Css 3compartmentss Human 95% 16.88 mg/L 2.482 mg/L 6.80096696212732 +DTXSID8044597 Css 3compartmentss Human 95% 19.18 mg/L 34.95 mg/L 0.548783977110157 +DTXSID8044599 Css 3compartmentss Human 95% 1.241 mg/L NA NA NA +DTXSID8044620 Css 3compartmentss Human 95% 0.6049 mg/L 0.01812 mg/L 33.3830022075055 +DTXSID8044626 Css 3compartmentss Human 95% 3.196 mg/L 13.86 mg/L 0.230591630591631 +DTXSID8044670 Css 3compartmentss Human 95% 7.848 mg/L 0.4365 mg/L 17.979381443299 +DTXSID8044678 Css 3compartmentss Human 95% 0.6819 mg/L 2.398 mg/L 0.284361968306922 +DTXSID8044701 Css 3compartmentss Human 95% 1.599 mg/L 0.1939 mg/L 8.24651882413615 +DTXSID8044703 Css 3compartmentss Human 95% 2.522 mg/L 2.598 mg/L 0.970746728252502 +DTXSID8044709 Css 3compartmentss Human 95% 1.239 mg/L 0.7824 mg/L 1.58358895705521 +DTXSID8044751 Css 3compartmentss Human 95% 4.436 mg/L 7.445 mg/L 0.595836131631968 +DTXSID8044830 Css 3compartmentss Human 95% 0.4715 mg/L 1.76 mg/L 0.267897727272727 +DTXSID8044834 Css 3compartmentss Human 95% 2.92 mg/L 3.326 mg/L 0.877931449188214 +DTXSID8044836 Css 3compartmentss Human 95% 9.179 mg/L 9.376 mg/L 0.978988907849829 +DTXSID8044880 Css 3compartmentss Human 95% 7.331 mg/L 7.052 mg/L 1.03956324446965 +DTXSID8044882 Css 3compartmentss Human 95% 0.3725 mg/L 2.573 mg/L 0.144772638942868 +DTXSID8044884 Css 3compartmentss Human 95% 0.3236 mg/L 7.253 mg/L 0.0446160209568454 +DTXSID8044886 Css 3compartmentss Human 95% 5.462 mg/L 53.44 mg/L 0.102208083832335 +DTXSID8044888 Css 3compartmentss Human 95% 7.446 mg/L 11.38 mg/L 0.654305799648506 +DTXSID8044913 Css 3compartmentss Human 95% 0.9706 mg/L 0.5679 mg/L 1.70910371544286 +DTXSID8044915 Css 3compartmentss Human 95% 0.5933 mg/L 0.8251 mg/L 0.719064355835656 +DTXSID8044919 Css 3compartmentss Human 95% 1.377 mg/L 7.778 mg/L 0.177037798920031 +DTXSID8044963 Css 3compartmentss Human 95% 1.388 mg/L 28.54 mg/L 0.0486334968465312 +DTXSID8044967 Css 3compartmentss Human 95% 5.419 mg/L 4.806 mg/L 1.12754889721182 +DTXSID8045141 Css 3compartmentss Human 95% 1.123 mg/L 0.03442 mg/L 32.6263800116212 +DTXSID8045145 Css 3compartmentss Human 95% 0.2749 mg/L 0.7491 mg/L 0.366973701775464 +DTXSID8045147 Css 3compartmentss Human 95% 1.939 mg/L 1.489 mg/L 1.30221625251847 +DTXSID8045149 Css 3compartmentss Human 95% 1.439 mg/L 1.241 mg/L 1.15954875100725 +DTXSID8045191 Css 3compartmentss Human 95% 0.7678 mg/L 1.012 mg/L 0.758695652173913 +DTXSID8045193 Css 3compartmentss Human 95% 3.616 mg/L 5.632 mg/L 0.642045454545455 +DTXSID8045195 Css 3compartmentss Human 95% 0.6379 mg/L 1.272 mg/L 0.501493710691824 +DTXSID8045220 Css 3compartmentss Human 95% 0.5859 mg/L 0.7 mg/L 0.837 +DTXSID8045222 Css 3compartmentss Human 95% 3.968 mg/L 0.3102 mg/L 12.7917472598324 +DTXSID8045224 Css 3compartmentss Human 95% 1.211 mg/L 72.88 mg/L 0.0166163556531284 +DTXSID8045228 Css 3compartmentss Human 95% 6.263 mg/L 24.31 mg/L 0.257630604689428 +DTXSID8045305 Css 3compartmentss Human 95% 58.05 mg/L 12.81 mg/L 4.53161592505855 +DTXSID8045307 Css 3compartmentss Human 95% 33.08 mg/L 18.99 mg/L 1.74196945760927 +DTXSID8045351 Css 3compartmentss Human 95% 2.275 mg/L 4.432 mg/L 0.513312274368231 +DTXSID8045357 Css 3compartmentss Human 95% 0.4684 mg/L 1.511 mg/L 0.309993381866314 +DTXSID8045359 Css 3compartmentss Human 95% 0.8979 mg/L 1.489 mg/L 0.603022162525185 +DTXSID8045432 Css 3compartmentss Human 95% 5.915 mg/L 0.1224 mg/L 48.3251633986928 +DTXSID8045434 Css 3compartmentss Human 95% 8.339 mg/L 0.4399 mg/L 18.9565810411457 +DTXSID8045438 Css 3compartmentss Human 95% 0.9126 mg/L 1.272 mg/L 0.717452830188679 +DTXSID8045480 Css 3compartmentss Human 95% 2.939 mg/L 5.459 mg/L 0.5383769921231 +DTXSID8045484 Css 3compartmentss Human 95% 6.133 mg/L 0.4847 mg/L 12.6531875386837 +DTXSID8045486 Css 3compartmentss Human 95% 194.8 mg/L 214.3 mg/L 0.909006066262249 +DTXSID8045488 Css 3compartmentss Human 95% 1.332 mg/L 38.32 mg/L 0.0347599164926931 +DTXSID8045511 Css 3compartmentss Human 95% 3.778 mg/L 30.8 mg/L 0.122662337662338 +DTXSID8045513 Css 3compartmentss Human 95% 10.7 mg/L 6.594 mg/L 1.6226872914771 +DTXSID8045515 Css 3compartmentss Human 95% 1.168 mg/L 0.004229 mg/L 276.18822416647 +DTXSID8045519 Css 3compartmentss Human 95% 0.9772 mg/L 1.459 mg/L 0.669773817683345 +DTXSID8045561 Css 3compartmentss Human 95% 4.492 mg/L 2.283 mg/L 1.96758650897941 +DTXSID8045563 Css 3compartmentss Human 95% 1.776 mg/L 0.9917 mg/L 1.79086417263285 +DTXSID8045565 Css 3compartmentss Human 95% 1.246 mg/L 0.5412 mg/L 2.30229120473023 +DTXSID8045567 Css 3compartmentss Human 95% 24.36 mg/L 39.82 mg/L 0.611752887995982 +DTXSID8045569 Css 3compartmentss Human 95% 0.209 mg/L 0.5826 mg/L 0.35873669756265 +DTXSID8045640 Css 3compartmentss Human 95% 0.3873 mg/L 0.4552 mg/L 0.850834797891037 +DTXSID8045642 Css 3compartmentss Human 95% 2.41 mg/L 3.204 mg/L 0.752184769038702 +DTXSID8045646 Css 3compartmentss Human 95% 1.622 mg/L 22.41 mg/L 0.0723784024988844 +DTXSID8045648 Css 3compartmentss Human 95% 5.318 mg/L 1.586 mg/L 3.3530895334174 +DTXSID8045690 Css 3compartmentss Human 95% 1.518 mg/L 0.2625 mg/L 5.78285714285714 +DTXSID8045692 Css 3compartmentss Human 95% 0.2889 mg/L 1.352 mg/L 0.213683431952663 +DTXSID8045694 Css 3compartmentss Human 95% 5.158 mg/L 627 mg/L 0.00822647527910686 +DTXSID8045696 Css 3compartmentss Human 95% 6.584 mg/L 7.534 mg/L 0.873904964162463 +DTXSID8045698 Css 3compartmentss Human 95% 1.838 mg/L 7.301 mg/L 0.25174633611834 +DTXSID8045771 Css 3compartmentss Human 95% 1.322 mg/L 58.06 mg/L 0.02276954874268 +DTXSID8045773 Css 3compartmentss Human 95% 1.057 mg/L 0.5071 mg/L 2.0844014987182 +DTXSID8045775 Css 3compartmentss Human 95% 14.89 mg/L 52.61 mg/L 0.283026040676677 +DTXSID8045777 Css 3compartmentss Human 95% 3.145 mg/L 7.593 mg/L 0.414197286974845 +DTXSID8045779 Css 3compartmentss Human 95% 6.004 mg/L 6.966 mg/L 0.861900660350273 +DTXSID8045800 Css 3compartmentss Human 95% 1.077 mg/L 0.03194 mg/L 33.7194740137758 +DTXSID8045802 Css 3compartmentss Human 95% 0.7763 mg/L 1.154 mg/L 0.672703639514731 +DTXSID8045804 Css 3compartmentss Human 95% 3.091 mg/L 4.345 mg/L 0.711392405063291 +DTXSID8045806 Css 3compartmentss Human 95% 0.5777 mg/L 1.733 mg/L 0.3333525678015 +DTXSID80458181 Css 3compartmentss Human 95% 0.636 mg/L NA NA NA +DTXSID8045850 Css 3compartmentss Human 95% 4.57 mg/L 5.658 mg/L 0.807705903145988 +DTXSID8045852 Css 3compartmentss Human 95% 0.811 mg/L 3.244 mg/L 0.25 +DTXSID8045854 Css 3compartmentss Human 95% 6.255 mg/L 2.011 mg/L 3.11039283938339 +DTXSID8045856 Css 3compartmentss Human 95% 4.025 mg/L 8.96 mg/L 0.44921875 +DTXSID8045933 Css 3compartmentss Human 95% 6.319 mg/L 0.3678 mg/L 17.1805328983143 +DTXSID8045935 Css 3compartmentss Human 95% 1.087 mg/L 1.379 mg/L 0.788252356780275 +DTXSID8045937 Css 3compartmentss Human 95% 2.5 mg/L 103 mg/L 0.0242718446601942 +DTXSID8045939 Css 3compartmentss Human 95% 0.9356 mg/L 0.8533 mg/L 1.09644908004219 +DTXSID8045983 Css 3compartmentss Human 95% 7.692 mg/L 4.963 mg/L 1.54986903082813 +DTXSID8045985 Css 3compartmentss Human 95% 1.798 mg/L 1.14 mg/L 1.57719298245614 +DTXSID8045987 Css 3compartmentss Human 95% 5.23 mg/L 5.738 mg/L 0.911467410247473 +DTXSID8045989 Css 3compartmentss Human 95% 1.07 mg/L 1.881 mg/L 0.568846358320043 +DTXSID8046030 Css 3compartmentss Human 95% 4.308 mg/L 7.226 mg/L 0.596180459451979 +DTXSID8046034 Css 3compartmentss Human 95% 5.908 mg/L 6.911 mg/L 0.854869049341629 +DTXSID8046036 Css 3compartmentss Human 95% 11.72 mg/L 4.689 mg/L 2.49946683727874 +DTXSID8046038 Css 3compartmentss Human 95% 6.887 mg/L 0.6842 mg/L 10.0657702426191 +DTXSID8046084 Css 3compartmentss Human 95% 5.934 mg/L 7.544 mg/L 0.786585365853659 +DTXSID8046086 Css 3compartmentss Human 95% 1.312 mg/L 1.669 mg/L 0.786099460754943 +DTXSID8046088 Css 3compartmentss Human 95% 5.578 mg/L 8.633 mg/L 0.646125333024441 +DTXSID8046113 Css 3compartmentss Human 95% 0.4002 mg/L 1.077 mg/L 0.371587743732591 +DTXSID8046117 Css 3compartmentss Human 95% 0.6667 mg/L 3.996 mg/L 0.166841841841842 +DTXSID8046119 Css 3compartmentss Human 95% 0.8961 mg/L 0.2997 mg/L 2.98998998998999 +DTXSID8046161 Css 3compartmentss Human 95% 1.851 mg/L 5.616 mg/L 0.329594017094017 +DTXSID8046163 Css 3compartmentss Human 95% 0.9768 mg/L 1.908 mg/L 0.511949685534591 +DTXSID8046165 Css 3compartmentss Human 95% 1.314 mg/L 2.977 mg/L 0.44138394356735 +DTXSID8046167 Css 3compartmentss Human 95% 0.081 mg/L NA NA NA +DTXSID8046169 Css 3compartmentss Human 95% 0.07474 mg/L 0.001595 mg/L 46.858934169279 +DTXSID8046240 Css 3compartmentss Human 95% 8.955 mg/L 22.12 mg/L 0.404837251356239 +DTXSID8046242 Css 3compartmentss Human 95% 5.328 mg/L 2.792 mg/L 1.90830945558739 +DTXSID8046244 Css 3compartmentss Human 95% 13.2 mg/L 433.2 mg/L 0.0304709141274238 +DTXSID8046246 Css 3compartmentss Human 95% 7.293 mg/L 0.3848 mg/L 18.9527027027027 +DTXSID8046248 Css 3compartmentss Human 95% 0.2226 mg/L 0.05429 mg/L 4.10020261558298 +DTXSID8046292 Css 3compartmentss Human 95% 3.366 mg/L 58.85 mg/L 0.057196261682243 +DTXSID8046294 Css 3compartmentss Human 95% 2.321 mg/L 3.751 mg/L 0.618768328445748 +DTXSID8046296 Css 3compartmentss Human 95% 4.936 mg/L 2.035 mg/L 2.42555282555283 +DTXSID8046298 Css 3compartmentss Human 95% 7.698 mg/L 1.754 mg/L 4.38882554161916 +DTXSID8046321 Css 3compartmentss Human 95% 7.934 mg/L 3.407 mg/L 2.32873495744056 +DTXSID8046323 Css 3compartmentss Human 95% 7.545 mg/L 0.7883 mg/L 9.57122922745148 +DTXSID8046325 Css 3compartmentss Human 95% 0.9463 mg/L 1.733 mg/L 0.546047316791691 +DTXSID8046327 Css 3compartmentss Human 95% 6.48 mg/L 1.732 mg/L 3.74133949191686 +DTXSID8046400 Css 3compartmentss Human 95% 2.695 mg/L 0.1686 mg/L 15.9845788849348 +DTXSID8046402 Css 3compartmentss Human 95% 0.3963 mg/L 1.404 mg/L 0.282264957264957 +DTXSID8046404 Css 3compartmentss Human 95% 3.367 mg/L 0.9946 mg/L 3.38528051477981 +DTXSID8046406 Css 3compartmentss Human 95% 7.957 mg/L 12.32 mg/L 0.64586038961039 +DTXSID8046450 Css 3compartmentss Human 95% 10.44 mg/L 5.823 mg/L 1.79289026275116 +DTXSID8046452 Css 3compartmentss Human 95% 13.67 mg/L 6.427 mg/L 2.12696436906799 +DTXSID8046454 Css 3compartmentss Human 95% 10.2 mg/L 0.3323 mg/L 30.6951549804394 +DTXSID8046456 Css 3compartmentss Human 95% 12.59 mg/L 0.3405 mg/L 36.9750367107195 +DTXSID8046458 Css 3compartmentss Human 95% 4.468 mg/L 7.297 mg/L 0.61230642729889 +DTXSID8046531 Css 3compartmentss Human 95% 8.289 mg/L 2.487 mg/L 3.3329312424608 +DTXSID8046539 Css 3compartmentss Human 95% 5.236 mg/L 9.204 mg/L 0.568883094306823 +DTXSID8046581 Css 3compartmentss Human 95% 7.398 mg/L 6.808 mg/L 1.08666274970623 +DTXSID8046585 Css 3compartmentss Human 95% 5.572 mg/L 55.97 mg/L 0.0995533321422191 +DTXSID8046589 Css 3compartmentss Human 95% 14.89 mg/L 51.81 mg/L 0.287396255549122 +DTXSID8046610 Css 3compartmentss Human 95% 0.5338 mg/L 4.867 mg/L 0.109677419354839 +DTXSID8046618 Css 3compartmentss Human 95% 6.005 mg/L 0.5458 mg/L 11.0021986075486 +DTXSID8046660 Css 3compartmentss Human 95% 6.437 mg/L 8.548 mg/L 0.753041647168928 +DTXSID8046662 Css 3compartmentss Human 95% 3.787 mg/L 4.124 mg/L 0.918283220174588 +DTXSID8046664 Css 3compartmentss Human 95% 7.277 mg/L 1.508 mg/L 4.82559681697613 +DTXSID8046743 Css 3compartmentss Human 95% 8.131 mg/L 16.75 mg/L 0.485432835820896 +DTXSID8046749 Css 3compartmentss Human 95% 5630 mg/L 0.02362 mg/L 238357.324301439 +DTXSID8046791 Css 3compartmentss Human 95% 8.046 mg/L 3.582 mg/L 2.24623115577889 +DTXSID8046793 Css 3compartmentss Human 95% 0.0431 mg/L 0.03524 mg/L 1.22304199772985 +DTXSID8046795 Css 3compartmentss Human 95% 4.97 mg/L 3.214 mg/L 1.54635967641568 +DTXSID8046799 Css 3compartmentss Human 95% 9.209 mg/L 9.605 mg/L 0.958771473191046 +DTXSID8046822 Css 3compartmentss Human 95% 13.57 mg/L 24.3 mg/L 0.55843621399177 +DTXSID8046824 Css 3compartmentss Human 95% 5.541 mg/L 5.487 mg/L 1.0098414434117 +DTXSID8046828 Css 3compartmentss Human 95% 4.674 mg/L 7.718 mg/L 0.605597305001296 +DTXSID8046870 Css 3compartmentss Human 95% 6.675 mg/L 0.6366 mg/L 10.4853911404336 +DTXSID8046876 Css 3compartmentss Human 95% 7.25 mg/L 0.02038 mg/L 355.740922473013 +DTXSID8046878 Css 3compartmentss Human 95% 4.964 mg/L 5.637 mg/L 0.880610253681036 +DTXSID8046903 Css 3compartmentss Human 95% 0.8313 mg/L 20.29 mg/L 0.040970921636274 +DTXSID8046905 Css 3compartmentss Human 95% 2.536 mg/L 570.4 mg/L 0.00444600280504909 +DTXSID8046909 Css 3compartmentss Human 95% 4.434 mg/L 7.234 mg/L 0.612938899640586 +DTXSID8046951 Css 3compartmentss Human 95% 1.738 mg/L 2.357 mg/L 0.737378022910479 +DTXSID8047000 Css 3compartmentss Human 95% 0.35 mg/L NA NA NA +DTXSID8047006 Css 3compartmentss Human 95% 13.95 mg/L 103.3 mg/L 0.135043562439497 +DTXSID8047050 Css 3compartmentss Human 95% 3.411 mg/L NA NA NA +DTXSID8047056 Css 3compartmentss Human 95% 0.2136 mg/L 0.02624 mg/L 8.14024390243902 +DTXSID8047058 Css 3compartmentss Human 95% 0.2677 mg/L 0.4723 mg/L 0.566800762227398 +DTXSID8047131 Css 3compartmentss Human 95% 2.553 mg/L NA NA NA +DTXSID8047137 Css 3compartmentss Human 95% 0.3167 mg/L 9.78 mg/L 0.0323824130879346 +DTXSID8047183 Css 3compartmentss Human 95% 1.305 mg/L 37.9 mg/L 0.0344327176781003 +DTXSID8047185 Css 3compartmentss Human 95% 7.874 mg/L NA NA NA +DTXSID8047187 Css 3compartmentss Human 95% 19.66 mg/L NA NA NA +DTXSID8047262 Css 3compartmentss Human 95% 14.09 mg/L 620 mg/L 0.0227258064516129 +DTXSID8047264 Css 3compartmentss Human 95% 1.361 mg/L 56.72 mg/L 0.0239950634696756 +DTXSID8047266 Css 3compartmentss Human 95% 4.4 mg/L 5.036 mg/L 0.873709293089754 +DTXSID8047268 Css 3compartmentss Human 95% 5.514 mg/L 66.01 mg/L 0.0835327980608999 +DTXSID8047341 Css 3compartmentss Human 95% 15.95 mg/L 19.63 mg/L 0.812531839021905 +DTXSID8047347 Css 3compartmentss Human 95% 3.623 mg/L 1.754 mg/L 2.06556442417332 +DTXSID8047349 Css 3compartmentss Human 95% 0.9626 mg/L 13.58 mg/L 0.0708836524300442 +DTXSID8047391 Css 3compartmentss Human 95% 5.346 mg/L 12.32 mg/L 0.433928571428571 +DTXSID8047397 Css 3compartmentss Human 95% 6.645 mg/L 0.392 mg/L 16.9515306122449 +DTXSID8047399 Css 3compartmentss Human 95% 8.302 mg/L NA NA NA +DTXSID8047420 Css 3compartmentss Human 95% 0.4082 mg/L 0.8851 mg/L 0.461190825895379 +DTXSID8047426 Css 3compartmentss Human 95% 0.7069 mg/L NA NA NA +DTXSID8047428 Css 3compartmentss Human 95% 1.591 mg/L 0.3052 mg/L 5.2129750982962 +DTXSID8047474 Css 3compartmentss Human 95% 6.152 mg/L NA NA NA +DTXSID8047505 Css 3compartmentss Human 95% 61.53 mg/L 174.8 mg/L 0.352002288329519 +DTXSID8047551 Css 3compartmentss Human 95% 1.215 mg/L 25.07 mg/L 0.0484642999601117 +DTXSID8047680 Css 3compartmentss Human 95% 0.6013 mg/L 1.719 mg/L 0.349796393251891 +DTXSID8047684 Css 3compartmentss Human 95% 7.52 mg/L NA NA NA +DTXSID8047686 Css 3compartmentss Human 95% 10.91 mg/L 18.07 mg/L 0.603763143331489 +DTXSID8047713 Css 3compartmentss Human 95% 0.9307 mg/L 0.2206 mg/L 4.21894832275612 +DTXSID8047717 Css 3compartmentss Human 95% 1.582 mg/L 3.906 mg/L 0.405017921146953 +DTXSID8047840 Css 3compartmentss Human 95% 0.9763 mg/L 0.02741 mg/L 35.6183874498358 +DTXSID8047842 Css 3compartmentss Human 95% 1.15 mg/L 0.6074 mg/L 1.89331577214356 +DTXSID8047844 Css 3compartmentss Human 95% 1.052 mg/L 5.156 mg/L 0.204034134988363 +DTXSID8047846 Css 3compartmentss Human 95% 8.088 mg/L 8.569 mg/L 0.943867429104913 +DTXSID8047848 Css 3compartmentss Human 95% 1.177 mg/L 1.178 mg/L 0.999151103565365 +DTXSID8047890 Css 3compartmentss Human 95% 3.882 mg/L 2.001 mg/L 1.9400299850075 +DTXSID8047894 Css 3compartmentss Human 95% 9.222 mg/L 5.87 mg/L 1.57103918228279 +DTXSID8047896 Css 3compartmentss Human 95% 20.81 mg/L 39.72 mg/L 0.523917421953676 +DTXSID8047898 Css 3compartmentss Human 95% 6.617 mg/L 7.712 mg/L 0.858013485477178 +DTXSID8047927 Css 3compartmentss Human 95% 3.81 mg/L 4.372 mg/L 0.871454711802379 +DTXSID8047929 Css 3compartmentss Human 95% 0.4119 mg/L NA NA NA +DTXSID8047973 Css 3compartmentss Human 95% 21.98 mg/L 3.862 mg/L 5.69135163127913 +DTXSID8048234 Css 3compartmentss Human 95% 8.391 mg/L NA NA NA +DTXSID8048238 Css 3compartmentss Human 95% 4.951 mg/L NA NA NA +DTXSID8048280 Css 3compartmentss Human 95% 23.9 mg/L NA NA NA +DTXSID8048282 Css 3compartmentss Human 95% 3.112 mg/L NA NA NA +DTXSID8048286 Css 3compartmentss Human 95% 0.1806 mg/L NA NA NA +DTXSID8048317 Css 3compartmentss Human 95% 1.3 mg/L NA NA NA +DTXSID8048446 Css 3compartmentss Human 95% 0.3088 mg/L NA NA NA +DTXSID8048490 Css 3compartmentss Human 95% 4.481 mg/L NA NA NA +DTXSID8048492 Css 3compartmentss Human 95% 4.68 mg/L NA NA NA +DTXSID8048494 Css 3compartmentss Human 95% 0.9694 mg/L 0.8533 mg/L 1.13606000234384 +DTXSID8048496 Css 3compartmentss Human 95% 8.658 mg/L NA NA NA +DTXSID8048521 Css 3compartmentss Human 95% 6.976 mg/L 0.9079 mg/L 7.68366560193854 +DTXSID8048529 Css 3compartmentss Human 95% 2.348 mg/L NA NA NA +DTXSID8048575 Css 3compartmentss Human 95% 0.1535 mg/L 0.162 mg/L 0.947530864197531 +DTXSID8048577 Css 3compartmentss Human 95% 0.6125 mg/L 4.368 mg/L 0.140224358974359 +DTXSID8048579 Css 3compartmentss Human 95% 57.33 mg/L 0.3584 mg/L 159.9609375 +DTXSID8048600 Css 3compartmentss Human 95% 12.72 mg/L 3.541 mg/L 3.59220559164078 +DTXSID8048602 Css 3compartmentss Human 95% 1.449 mg/L 0.3012 mg/L 4.81075697211155 +DTXSID8048606 Css 3compartmentss Human 95% 13.47 mg/L 16.86 mg/L 0.798932384341637 +DTXSID8048650 Css 3compartmentss Human 95% 7.822 mg/L 53.12 mg/L 0.147251506024096 +DTXSID8048652 Css 3compartmentss Human 95% 1.94 mg/L 165.4 mg/L 0.0117291414752116 +DTXSID8048654 Css 3compartmentss Human 95% 5.808 mg/L 1.716 mg/L 3.38461538461538 +DTXSID8048656 Css 3compartmentss Human 95% 0.8253 mg/L 0.8648 mg/L 0.954324699352451 +DTXSID8048658 Css 3compartmentss Human 95% 9.799 mg/L 14.18 mg/L 0.691043723554302 +DTXSID8048731 Css 3compartmentss Human 95% 19.84 mg/L 12.01 mg/L 1.65195670274771 +DTXSID8048733 Css 3compartmentss Human 95% 81.14 mg/L 7.722 mg/L 10.5076405076405 +DTXSID8048735 Css 3compartmentss Human 95% 4.326 mg/L 2.283 mg/L 1.89487516425756 +DTXSID8048737 Css 3compartmentss Human 95% 2.875 mg/L 6.911 mg/L 0.416003472724642 +DTXSID8048739 Css 3compartmentss Human 95% 2.995 mg/L 5.505 mg/L 0.544050862851953 +DTXSID8048781 Css 3compartmentss Human 95% 1.023 mg/L 8.939 mg/L 0.114442331356975 +DTXSID8048783 Css 3compartmentss Human 95% 2.091 mg/L 256.8 mg/L 0.00814252336448598 +DTXSID8048785 Css 3compartmentss Human 95% 231.8 mg/L 222.2 mg/L 1.04320432043204 +DTXSID8048787 Css 3compartmentss Human 95% 29.45 mg/L 96.71 mg/L 0.304518664047151 +DTXSID8048789 Css 3compartmentss Human 95% 0.5304 mg/L 3.224 mg/L 0.164516129032258 +DTXSID8048810 Css 3compartmentss Human 95% 0.7677 mg/L 4.897 mg/L 0.156769450684092 +DTXSID8048812 Css 3compartmentss Human 95% 6.799 mg/L 0.6572 mg/L 10.3454047474133 +DTXSID8048814 Css 3compartmentss Human 95% 2.607 mg/L 5.592 mg/L 0.466201716738197 +DTXSID8048816 Css 3compartmentss Human 95% 1.032 mg/L 1.291 mg/L 0.799380325329202 +DTXSID8048818 Css 3compartmentss Human 95% 4.258 mg/L 6.019 mg/L 0.707426482804453 +DTXSID8048860 Css 3compartmentss Human 95% 1.081 mg/L 6.124 mg/L 0.176518615284128 +DTXSID8048862 Css 3compartmentss Human 95% 4.941 mg/L 6.139 mg/L 0.804854210783515 +DTXSID8048864 Css 3compartmentss Human 95% 0.243 mg/L 0.372 mg/L 0.653225806451613 +DTXSID8048866 Css 3compartmentss Human 95% 0.5217 mg/L 1.519 mg/L 0.343449637919684 +DTXSID8048868 Css 3compartmentss Human 95% 0.2801 mg/L 0.3296 mg/L 0.849817961165049 +DTXSID8048941 Css 3compartmentss Human 95% 0.9457 mg/L 0.6429 mg/L 1.47099082283403 +DTXSID8048943 Css 3compartmentss Human 95% 5.053 mg/L 8.153 mg/L 0.619771863117871 +DTXSID8048945 Css 3compartmentss Human 95% 14.19 mg/L 42.84 mg/L 0.331232492997199 +DTXSID8048947 Css 3compartmentss Human 95% 42.4 mg/L 138.4 mg/L 0.30635838150289 +DTXSID8048949 Css 3compartmentss Human 95% 11.9 mg/L 0.1745 mg/L 68.1948424068768 +DTXSID8048991 Css 3compartmentss Human 95% 0.03179 mg/L 0.03675 mg/L 0.865034013605442 +DTXSID8048995 Css 3compartmentss Human 95% 4.48 mg/L 3.829 mg/L 1.17001828153565 +DTXSID8048997 Css 3compartmentss Human 95% 7.11 mg/L 3.733 mg/L 1.904634342352 +DTXSID8048999 Css 3compartmentss Human 95% 2.706 mg/L 8.837 mg/L 0.306212515559579 +DTXSID8049040 Css 3compartmentss Human 95% 1.21 mg/L 1.792 mg/L 0.675223214285714 +DTXSID8049042 Css 3compartmentss Human 95% 1.47 mg/L 2.973 mg/L 0.494450050454087 +DTXSID8049044 Css 3compartmentss Human 95% 2.35 mg/L 33.37 mg/L 0.0704225352112676 +DTXSID8049046 Css 3compartmentss Human 95% 18.69 mg/L 34.58 mg/L 0.540485829959514 +DTXSID8049048 Css 3compartmentss Human 95% 2.765 mg/L 8.556 mg/L 0.323165030388032 +DTXSID8049208 Css 3compartmentss Human 95% 2.218 mg/L 1.945 mg/L 1.14035989717224 +DTXSID8049331 Css 3compartmentss Human 95% 1.312 mg/L 6.67 mg/L 0.196701649175412 +DTXSID8049337 Css 3compartmentss Human 95% 0.3113 mg/L 6.016 mg/L 0.0517453457446809 +DTXSID8049387 Css 3compartmentss Human 95% 6329 mg/L 79.26 mg/L 79.851122886702 +DTXSID8049410 Css 3compartmentss Human 95% 1.519 mg/L 1.758 mg/L 0.864050056882821 +DTXSID8049412 Css 3compartmentss Human 95% 0.4044 mg/L 4.641 mg/L 0.087136393018746 +DTXSID8049414 Css 3compartmentss Human 95% 9.634 mg/L 15.28 mg/L 0.630497382198953 +DTXSID8049416 Css 3compartmentss Human 95% 7.349 mg/L 2.213 mg/L 3.32083145051966 +DTXSID8049418 Css 3compartmentss Human 95% 0.3431 mg/L 5.13 mg/L 0.0668810916179337 +DTXSID8051540 Css 3compartmentss Human 95% 10.73 mg/L NA NA NA +DTXSID8051629 Css 3compartmentss Human 95% 5.104 mg/L 5.53 mg/L 0.922965641952984 +DTXSID8051708 Css 3compartmentss Human 95% 1.731 mg/L 5.472 mg/L 0.316337719298246 +DTXSID8051754 Css 3compartmentss Human 95% 0.4664 mg/L 9.613 mg/L 0.0485176323728285 +DTXSID8051914 Css 3compartmentss Human 95% 12.11 mg/L 0.97 mg/L 12.4845360824742 +DTXSID8052300 Css 3compartmentss Human 95% 5.125 mg/L 1.268 mg/L 4.04179810725552 +DTXSID8052308 Css 3compartmentss Human 95% 5.145 mg/L 5.519 mg/L 0.932234100380504 +DTXSID8052510 Css 3compartmentss Human 95% 0.2377 mg/L NA NA NA +DTXSID8052641 Css 3compartmentss Human 95% 2.532 mg/L 13.37 mg/L 0.189379207180254 +DTXSID8052645 Css 3compartmentss Human 95% 8.826 mg/L NA NA NA +DTXSID8052699 Css 3compartmentss Human 95% 6.56 mg/L NA NA NA +DTXSID8052724 Css 3compartmentss Human 95% 4.057 mg/L 25.24 mg/L 0.160736925515056 +DTXSID8057641 Css 3compartmentss Human 95% 21.02 mg/L 49.88 mg/L 0.421411387329591 +DTXSID8057643 Css 3compartmentss Human 95% 3.078 mg/L 1.293 mg/L 2.38051044083527 +DTXSID8057645 Css 3compartmentss Human 95% 9.099 mg/L 0.7635 mg/L 11.9174852652259 +DTXSID8057647 Css 3compartmentss Human 95% 22.99 mg/L 42.8 mg/L 0.53714953271028 +DTXSID8057649 Css 3compartmentss Human 95% 47.79 mg/L 12.4 mg/L 3.85403225806452 +DTXSID8057691 Css 3compartmentss Human 95% 9.371 mg/L 33.26 mg/L 0.281749849669272 +DTXSID8057693 Css 3compartmentss Human 95% 2.925 mg/L 922.2 mg/L 0.00317176317501627 +DTXSID8057695 Css 3compartmentss Human 95% 9.177 mg/L 14.62 mg/L 0.627701778385773 +DTXSID8057697 Css 3compartmentss Human 95% 21.97 mg/L 0.9785 mg/L 22.452733776188 +DTXSID8057699 Css 3compartmentss Human 95% 1.224 mg/L 0.8819 mg/L 1.38791246173035 +DTXSID8057720 Css 3compartmentss Human 95% 0.9909 mg/L 0.13 mg/L 7.62230769230769 +DTXSID8057722 Css 3compartmentss Human 95% 1.46 mg/L 0.03237 mg/L 45.1034908866234 +DTXSID8057724 Css 3compartmentss Human 95% 0.7086 mg/L 0.4762 mg/L 1.48803023939521 +DTXSID8057726 Css 3compartmentss Human 95% 0.9187 mg/L 0.1737 mg/L 5.28900402993667 +DTXSID8057728 Css 3compartmentss Human 95% 9.584 mg/L 12.74 mg/L 0.752276295133438 +DTXSID8057770 Css 3compartmentss Human 95% 0.3711 mg/L 1.249 mg/L 0.297117694155324 +DTXSID8057772 Css 3compartmentss Human 95% 21.9 mg/L 131.7 mg/L 0.16628701594533 +DTXSID8057776 Css 3compartmentss Human 95% 8.143 mg/L 3.643 mg/L 2.23524567664013 +DTXSID8057778 Css 3compartmentss Human 95% 0.8513 mg/L 64.22 mg/L 0.0132559950171286 +DTXSID8057801 Css 3compartmentss Human 95% 4.566 mg/L 3.15 mg/L 1.44952380952381 +DTXSID8057803 Css 3compartmentss Human 95% 0.2917 mg/L 0.1983 mg/L 1.47100353000504 +DTXSID8057805 Css 3compartmentss Human 95% 1.558 mg/L 22.85 mg/L 0.0681838074398249 +DTXSID8057807 Css 3compartmentss Human 95% 7.12 mg/L 1.052 mg/L 6.7680608365019 +DTXSID8057809 Css 3compartmentss Human 95% 4.851 mg/L 24.93 mg/L 0.194584837545126 +DTXSID8057851 Css 3compartmentss Human 95% 0.43 mg/L 0.9774 mg/L 0.439942705136075 +DTXSID8057853 Css 3compartmentss Human 95% 1.987 mg/L 60.14 mg/L 0.0330395743265713 +DTXSID8057855 Css 3compartmentss Human 95% 0.938 mg/L 0.671 mg/L 1.39791356184799 +DTXSID8057857 Css 3compartmentss Human 95% 15.7 mg/L 1.803 mg/L 8.70770937326678 +DTXSID8059766 Css 3compartmentss Human 95% 8.732 mg/L NA NA NA +DTXSID8060539 Css 3compartmentss Human 95% 18.84 mg/L NA NA NA +DTXSID8060614 Css 3compartmentss Human 95% 13.72 mg/L NA NA NA +DTXSID8060878 Css 3compartmentss Human 95% 12.01 mg/L NA NA NA +DTXSID8060905 Css 3compartmentss Human 95% 2.41 mg/L NA NA NA +DTXSID8061684 Css 3compartmentss Human 95% 4.834 mg/L NA NA NA +DTXSID80648969 Css 3compartmentss Human 95% 1.841 mg/L NA NA NA +DTXSID80655299 Css 3compartmentss Human 95% 1.592 mg/L NA NA NA +DTXSID80676308 Css 3compartmentss Human 95% 4.815 mg/L NA NA NA +DTXSID8073928 Css 3compartmentss Human 95% 21.41 mg/L NA NA NA +DTXSID8075205 Css 3compartmentss Human 95% 18.53 mg/L NA NA NA +DTXSID80859119 Css 3compartmentss Human 95% 12.35 mg/L NA NA NA +DTXSID80859311 Css 3compartmentss Human 95% 2.318 mg/L NA NA NA +DTXSID80862527 Css 3compartmentss Human 95% 10.43 mg/L NA NA NA +DTXSID80864425 Css 3compartmentss Human 95% 4.833 mg/L NA NA NA +DTXSID80867815 Css 3compartmentss Human 95% 0.3796 mg/L NA NA NA +DTXSID80869253 Css 3compartmentss Human 95% 45.58 mg/L NA NA NA +DTXSID80869455 Css 3compartmentss Human 95% 1.137 mg/L NA NA NA +DTXSID80870086 Css 3compartmentss Human 95% 43.68 mg/L NA NA NA +DTXSID80872343 Css 3compartmentss Human 95% 0.7678 mg/L NA NA NA +DTXSID80873219 Css 3compartmentss Human 95% 24.71 mg/L NA NA NA +DTXSID80873976 Css 3compartmentss Human 95% 2.786 mg/L NA NA NA +DTXSID80879993 Css 3compartmentss Human 95% 7.85 mg/L NA NA NA +DTXSID80880685 Css 3compartmentss Human 95% 1.327 mg/L NA NA NA +DTXSID80880706 Css 3compartmentss Human 95% 0.4234 mg/L NA NA NA +DTXSID80880882 Css 3compartmentss Human 95% 6.006 mg/L NA NA NA +DTXSID80880887 Css 3compartmentss Human 95% 0.7308 mg/L NA NA NA +DTXSID80880908 Css 3compartmentss Human 95% 20.48 mg/L NA NA NA +DTXSID80880923 Css 3compartmentss Human 95% 1.002 mg/L NA NA NA +DTXSID80881091 Css 3compartmentss Human 95% 3.937 mg/L NA NA NA +DTXSID80891478 Css 3compartmentss Human 95% 2.289 mg/L NA NA NA +DTXSID80894126 Css 3compartmentss Human 95% 0.7632 mg/L NA NA NA +DTXSID80904653 Css 3compartmentss Human 95% 44.83 mg/L NA NA NA +DTXSID80914272 Css 3compartmentss Human 95% 1.995 mg/L NA NA NA +DTXSID80919666 Css 3compartmentss Human 95% 2.085 mg/L NA NA NA +DTXSID80923001 Css 3compartmentss Human 95% 4.901 mg/L NA NA NA +DTXSID80965062 Css 3compartmentss Human 95% 12.31 mg/L NA NA NA +DTXSID901007381 Css 3compartmentss Human 95% 9.487 mg/L NA NA NA +DTXSID901009337 Css 3compartmentss Human 95% 65.88 mg/L NA NA NA +DTXSID901017944 Css 3compartmentss Human 95% 9.906 mg/L 262 mg/L 0.0378091603053435 +DTXSID901122470 Css 3compartmentss Human 95% 5.072 mg/L NA NA NA +DTXSID901179952 Css 3compartmentss Human 95% 11.17 mg/L NA NA NA +DTXSID90145616 Css 3compartmentss Human 95% 7.688 mg/L NA NA NA +DTXSID90154283 Css 3compartmentss Human 95% 2.988 mg/L NA NA NA +DTXSID90158605 Css 3compartmentss Human 95% 0.5115 mg/L NA NA NA +DTXSID90164605 Css 3compartmentss Human 95% 6.981 mg/L NA NA NA +DTXSID90166700 Css 3compartmentss Human 95% 2.516 mg/L NA NA NA +DTXSID90174648 Css 3compartmentss Human 95% 2.303 mg/L NA NA NA +DTXSID90179850 Css 3compartmentss Human 95% 5.957 mg/L NA NA NA +DTXSID90185198 Css 3compartmentss Human 95% 19.81 mg/L 19.39 mg/L 1.02166064981949 +DTXSID90197271 Css 3compartmentss Human 95% 0.3661 mg/L NA NA NA +DTXSID90198647 Css 3compartmentss Human 95% 8.932 mg/L NA NA NA +DTXSID9020031 Css 3compartmentss Human 95% 0.03475 mg/L 0.03425 mg/L 1.01459854014599 +DTXSID9020035 Css 3compartmentss Human 95% 3.744 mg/L 2.515 mg/L 1.48866799204771 +DTXSID9020081 Css 3compartmentss Human 95% 3.768 mg/L 6.678 mg/L 0.564240790655885 +DTXSID9020089 Css 3compartmentss Human 95% 14.01 mg/L 7.753 mg/L 1.80704243518638 +DTXSID9020110 Css 3compartmentss Human 95% 2.162 mg/L 1.42 mg/L 1.52253521126761 +DTXSID9020112 Css 3compartmentss Human 95% 39.22 mg/L 41.08 mg/L 0.954722492697176 +DTXSID9020114 Css 3compartmentss Human 95% 2.165 mg/L 2.049 mg/L 1.05661298194241 +DTXSID9020116 Css 3compartmentss Human 95% 2.843 mg/L 5.395 mg/L 0.526969416126043 +DTXSID9020118 Css 3compartmentss Human 95% 5.618 mg/L 5.536 mg/L 1.01481213872832 +DTXSID9020160 Css 3compartmentss Human 95% 11740 mg/L 11240 mg/L 1.04448398576512 +DTXSID9020164 Css 3compartmentss Human 95% 0.3535 mg/L 7.953 mg/L 0.0444486357349428 +DTXSID9020168 Css 3compartmentss Human 95% 0.2989 mg/L 2.808 mg/L 0.106445868945869 +DTXSID9020241 Css 3compartmentss Human 95% 2.428 mg/L 11.66 mg/L 0.208233276157804 +DTXSID9020243 Css 3compartmentss Human 95% 2.47 mg/L 9.559 mg/L 0.25839522962653 +DTXSID9020245 Css 3compartmentss Human 95% 8.557 mg/L 1.105 mg/L 7.74389140271493 +DTXSID9020247 Css 3compartmentss Human 95% 0.2843 mg/L 0.3906 mg/L 0.727854582693292 +DTXSID9020249 Css 3compartmentss Human 95% 7.671 mg/L 7.891 mg/L 0.972120136864783 +DTXSID9020293 Css 3compartmentss Human 95% 0.7225 mg/L 1.039 mg/L 0.695380173243503 +DTXSID9020295 Css 3compartmentss Human 95% 8.401 mg/L 8.806 mg/L 0.954008630479219 +DTXSID9020299 Css 3compartmentss Human 95% 0.9673 mg/L 0.8391 mg/L 1.15278274341556 +DTXSID9020322 Css 3compartmentss Human 95% 28.33 mg/L 19.31 mg/L 1.46711548420508 +DTXSID9020328 Css 3compartmentss Human 95% 5.545 mg/L 40.33 mg/L 0.137490701710885 +DTXSID9020370 Css 3compartmentss Human 95% 0.4525 mg/L 0.5163 mg/L 0.876428433081542 +DTXSID9020372 Css 3compartmentss Human 95% 19.85 mg/L 15.73 mg/L 1.26191989828353 +DTXSID90203740 Css 3compartmentss Human 95% 76.77 mg/L NA NA NA +DTXSID9020376 Css 3compartmentss Human 95% 9276 mg/L NA NA NA +DTXSID9020378 Css 3compartmentss Human 95% 9.435 mg/L 0.9626 mg/L 9.80157905672138 +DTXSID9020401 Css 3compartmentss Human 95% 6.898 mg/L 0.1755 mg/L 39.3048433048433 +DTXSID9020407 Css 3compartmentss Human 95% 4.179 mg/L 4.2 mg/L 0.995 +DTXSID9020409 Css 3compartmentss Human 95% 1.517 mg/L 1.562 mg/L 0.971190781049936 +DTXSID9020451 Css 3compartmentss Human 95% 4.915 mg/L 23.55 mg/L 0.208704883227176 +DTXSID9020453 Css 3compartmentss Human 95% 2504 mg/L 2568 mg/L 0.975077881619938 +DTXSID9020459 Css 3compartmentss Human 95% 5.065 mg/L 2.322 mg/L 2.18130921619294 +DTXSID9020538 Css 3compartmentss Human 95% 10.78 mg/L 4.215 mg/L 2.55753262158956 +DTXSID9020580 Css 3compartmentss Human 95% 1.046 mg/L 2.067 mg/L 0.506047411707789 +DTXSID9020582 Css 3compartmentss Human 95% 28.86 mg/L 34.03 mg/L 0.848075227740229 +DTXSID9020584 Css 3compartmentss Human 95% 0.2291 mg/L 0.2701 mg/L 0.848204368752314 +DTXSID90205860 Css 3compartmentss Human 95% 0.1311 mg/L NA NA NA +DTXSID9020615 Css 3compartmentss Human 95% 71.87 mg/L 84.64 mg/L 0.849125708884688 +DTXSID9020617 Css 3compartmentss Human 95% 0.2028 mg/L 0.203 mg/L 0.999014778325123 +DTXSID90206493 Css 3compartmentss Human 95% 14.13 mg/L NA NA NA +DTXSID9020663 Css 3compartmentss Human 95% 4.35 mg/L 4.979 mg/L 0.873669411528419 +DTXSID9020667 Css 3compartmentss Human 95% 3.693 mg/L 4.22 mg/L 0.875118483412322 +DTXSID9020669 Css 3compartmentss Human 95% 8.623 mg/L 24.45 mg/L 0.352678936605317 +DTXSID9020740 Css 3compartmentss Human 95% 25.64 mg/L 26.26 mg/L 0.976389946686976 +DTXSID9020742 Css 3compartmentss Human 95% 4.927 mg/L 5.424 mg/L 0.908370206489675 +DTXSID9020790 Css 3compartmentss Human 95% 0.08676 mg/L 0.08566 mg/L 1.01284146626197 +DTXSID9020792 Css 3compartmentss Human 95% 2.64 mg/L 3.085 mg/L 0.855753646677472 +DTXSID9020794 Css 3compartmentss Human 95% 6.834 mg/L 2.105 mg/L 3.24655581947743 +DTXSID9020796 Css 3compartmentss Human 95% 9.243 mg/L 1.092 mg/L 8.46428571428571 +DTXSID9020821 Css 3compartmentss Human 95% 6.299 mg/L 5.533 mg/L 1.13844207482378 +DTXSID9020825 Css 3compartmentss Human 95% 2.184 mg/L 0.9777 mg/L 2.23381405339061 +DTXSID9020827 Css 3compartmentss Human 95% 28.52 mg/L 29.12 mg/L 0.979395604395604 +DTXSID9020829 Css 3compartmentss Human 95% 1.29 mg/L NA NA NA +DTXSID9020875 Css 3compartmentss Human 95% 7.611 mg/L 9.631 mg/L 0.790260616758384 +DTXSID9020902 Css 3compartmentss Human 95% 3.885 mg/L 0.6933 mg/L 5.60363479013414 +DTXSID90209085 Css 3compartmentss Human 95% 38.23 mg/L NA NA NA +DTXSID9020958 Css 3compartmentss Human 95% 0.3763 mg/L 1.21 mg/L 0.31099173553719 +DTXSID90210035 Css 3compartmentss Human 95% 20.49 mg/L NA NA NA +DTXSID9021053 Css 3compartmentss Human 95% 0.349 mg/L 0.07681 mg/L 4.5436792084364 +DTXSID9021059 Css 3compartmentss Human 95% 6.445 mg/L 4.626 mg/L 1.39321227842629 +DTXSID9021130 Css 3compartmentss Human 95% 1.494 mg/L 1.748 mg/L 0.854691075514874 +DTXSID9021132 Css 3compartmentss Human 95% 0.982 mg/L 3.726 mg/L 0.263553408480945 +DTXSID9021134 Css 3compartmentss Human 95% 0.407 mg/L 3.002 mg/L 0.135576282478348 +DTXSID9021136 Css 3compartmentss Human 95% 6.507 mg/L 239.4 mg/L 0.0271804511278195 +DTXSID9021138 Css 3compartmentss Human 95% 6.449 mg/L 0.9068 mg/L 7.1118217909131 +DTXSID90211380 Css 3compartmentss Human 95% 2.787 mg/L NA NA NA +DTXSID9021182 Css 3compartmentss Human 95% 1.055 mg/L 0.8518 mg/L 1.23855365109181 +DTXSID9021184 Css 3compartmentss Human 95% 1.183 mg/L 1.425 mg/L 0.830175438596491 +DTXSID9021188 Css 3compartmentss Human 95% 4.601 mg/L 8.288 mg/L 0.555139961389961 +DTXSID9021215 Css 3compartmentss Human 95% 5.717 mg/L 3.001 mg/L 1.90503165611463 +DTXSID9021217 Css 3compartmentss Human 95% 9.178 mg/L 9.8 mg/L 0.936530612244898 +DTXSID9021219 Css 3compartmentss Human 95% 14.24 mg/L 13.58 mg/L 1.04860088365243 +DTXSID9021267 Css 3compartmentss Human 95% 0.3786 mg/L 0.184 mg/L 2.05760869565217 +DTXSID9021340 Css 3compartmentss Human 95% 3.434 mg/L 4.042 mg/L 0.849579416130628 +DTXSID9021342 Css 3compartmentss Human 95% 26.87 mg/L 46.75 mg/L 0.57475935828877 +DTXSID9021344 Css 3compartmentss Human 95% 1.89 mg/L 1.518 mg/L 1.24505928853755 +DTXSID9021346 Css 3compartmentss Human 95% 0.8045 mg/L 0.9309 mg/L 0.864217423998281 +DTXSID9021348 Css 3compartmentss Human 95% 3.842 mg/L 4.717 mg/L 0.814500741997032 +DTXSID9021392 Css 3compartmentss Human 95% 1.814 mg/L 2.034 mg/L 0.891838741396264 +DTXSID9021396 Css 3compartmentss Human 95% 4.515 mg/L 5.548 mg/L 0.813806777217015 +DTXSID9021398 Css 3compartmentss Human 95% 0.7147 mg/L 3.372 mg/L 0.211951364175563 +DTXSID9021425 Css 3compartmentss Human 95% 1.012 mg/L 0.4148 mg/L 2.4397299903568 +DTXSID9021427 Css 3compartmentss Human 95% 6.07 mg/L 5.312 mg/L 1.14269578313253 +DTXSID9021479 Css 3compartmentss Human 95% 3.345 mg/L 4.112 mg/L 0.813472762645914 +DTXSID9021554 Css 3compartmentss Human 95% 2.253 mg/L 23.15 mg/L 0.0973218142548596 +DTXSID9021633 Css 3compartmentss Human 95% 7.16 mg/L 8.495 mg/L 0.842848734549735 +DTXSID9021683 Css 3compartmentss Human 95% 32.18 mg/L 42.39 mg/L 0.759141306912008 +DTXSID9021685 Css 3compartmentss Human 95% 7.416 mg/L 7.653 mg/L 0.969031752254018 +DTXSID9021689 Css 3compartmentss Human 95% 8.621 mg/L NA NA NA +DTXSID9021716 Css 3compartmentss Human 95% 1131 mg/L 1150 mg/L 0.983478260869565 +DTXSID9021718 Css 3compartmentss Human 95% 0.3191 mg/L 0.04151 mg/L 7.68730426403276 +DTXSID9021762 Css 3compartmentss Human 95% 5.058 mg/L 5.66 mg/L 0.893639575971731 +DTXSID9021764 Css 3compartmentss Human 95% 4.08 mg/L 4.772 mg/L 0.85498742665549 +DTXSID9021841 Css 3compartmentss Human 95% 0.385 mg/L 0.4211 mg/L 0.914272144383757 +DTXSID9021843 Css 3compartmentss Human 95% 0.3838 mg/L 1.631 mg/L 0.235315757204169 +DTXSID9021897 Css 3compartmentss Human 95% 0.2942 mg/L 1.884 mg/L 0.156157112526539 +DTXSID9021899 Css 3compartmentss Human 95% 0.3165 mg/L 1.713 mg/L 0.18476357267951 +DTXSID9021922 Css 3compartmentss Human 95% 6.643 mg/L 3.193 mg/L 2.08048856874413 +DTXSID9021924 Css 3compartmentss Human 95% 1.007 mg/L 1.233 mg/L 0.816707218167072 +DTXSID9021928 Css 3compartmentss Human 95% 0.2602 mg/L 0.08988 mg/L 2.89497107254117 +DTXSID9021974 Css 3compartmentss Human 95% 1.526 mg/L NA NA NA +DTXSID9021976 Css 3compartmentss Human 95% 9.962 mg/L 10.5 mg/L 0.948761904761905 +DTXSID9022027 Css 3compartmentss Human 95% 0.3204 mg/L 0.6863 mg/L 0.466851231239983 +DTXSID9022079 Css 3compartmentss Human 95% 5720 mg/L NA NA NA +DTXSID9022100 Css 3compartmentss Human 95% 2.234 mg/L 1.241 mg/L 1.80016116035455 +DTXSID9022310 Css 3compartmentss Human 95% 4.434 mg/L 4.41 mg/L 1.00544217687075 +DTXSID9022312 Css 3compartmentss Human 95% 27.7 mg/L 24.44 mg/L 1.13338788870704 +DTXSID9022360 Css 3compartmentss Human 95% 1.722 mg/L 3.527 mg/L 0.488233626311313 +DTXSID9022364 Css 3compartmentss Human 95% 1.891 mg/L 1.948 mg/L 0.970739219712526 +DTXSID9022366 Css 3compartmentss Human 95% 2.351 mg/L 57.05 mg/L 0.0412094653812445 +DTXSID9022445 Css 3compartmentss Human 95% 6.231 mg/L 2.812 mg/L 2.21586059743955 +DTXSID9022520 Css 3compartmentss Human 95% 2.134 mg/L NA NA NA +DTXSID9022522 Css 3compartmentss Human 95% 15.06 mg/L 16.11 mg/L 0.934823091247672 +DTXSID9022524 Css 3compartmentss Human 95% 1.53 mg/L 0.6062 mg/L 2.52391949851534 +DTXSID9022526 Css 3compartmentss Human 95% 0.8373 mg/L 0.8212 mg/L 1.01960545543108 +DTXSID9022528 Css 3compartmentss Human 95% 0.59 mg/L 0.7934 mg/L 0.743634988656415 +DTXSID90225664 Css 3compartmentss Human 95% 14.9 mg/L NA NA NA +DTXSID9022570 Css 3compartmentss Human 95% 49.18 mg/L 54.24 mg/L 0.906710914454277 +DTXSID9022574 Css 3compartmentss Human 95% 16.45 mg/L 28.43 mg/L 0.578614139992965 +DTXSID9022576 Css 3compartmentss Human 95% 2.392 mg/L 2.905 mg/L 0.823407917383821 +DTXSID9022578 Css 3compartmentss Human 95% 1.997 mg/L 58.71 mg/L 0.0340146482711633 +DTXSID9022601 Css 3compartmentss Human 95% 189.6 mg/L 218.9 mg/L 0.866148926450434 +DTXSID9022603 Css 3compartmentss Human 95% 5.039 mg/L 1.411 mg/L 3.57122608079376 +DTXSID9022607 Css 3compartmentss Human 95% 1.717 mg/L 9.262 mg/L 0.185381127186353 +DTXSID9022609 Css 3compartmentss Human 95% 3.563 mg/L 106.1 mg/L 0.0335815268614515 +DTXSID9022655 Css 3compartmentss Human 95% 48.87 mg/L 55.29 mg/L 0.883884970157352 +DTXSID9022657 Css 3compartmentss Human 95% 0.9582 mg/L 0.6338 mg/L 1.51183338592616 +DTXSID9022659 Css 3compartmentss Human 95% 1.379 mg/L 2.384 mg/L 0.578439597315436 +DTXSID9022730 Css 3compartmentss Human 95% 6.513 mg/L 5.235 mg/L 1.24412607449857 +DTXSID9022732 Css 3compartmentss Human 95% 5.182 mg/L 6.039 mg/L 0.858089087597284 +DTXSID9022734 Css 3compartmentss Human 95% 5.291 mg/L 4.987 mg/L 1.06095849207941 +DTXSID9022736 Css 3compartmentss Human 95% 6.374 mg/L 0.3533 mg/L 18.0413246532692 +DTXSID9022738 Css 3compartmentss Human 95% 3.129 mg/L 5.579 mg/L 0.560853199498118 +DTXSID9022780 Css 3compartmentss Human 95% 1.847 mg/L 1.736 mg/L 1.0639400921659 +DTXSID9022782 Css 3compartmentss Human 95% 0.3388 mg/L 0.7813 mg/L 0.433636247280174 +DTXSID9022784 Css 3compartmentss Human 95% 5.048 mg/L NA NA NA +DTXSID9022786 Css 3compartmentss Human 95% 58.68 mg/L 67.4 mg/L 0.870623145400593 +DTXSID9022811 Css 3compartmentss Human 95% 4.515 mg/L NA NA NA +DTXSID9022813 Css 3compartmentss Human 95% 1.947 mg/L 2.873 mg/L 0.677688827010094 +DTXSID9022815 Css 3compartmentss Human 95% 0.3239 mg/L 0.4315 mg/L 0.75063731170336 +DTXSID9022817 Css 3compartmentss Human 95% 148.9 mg/L 437.9 mg/L 0.340031970769582 +DTXSID9022819 Css 3compartmentss Human 95% 0.1152 mg/L NA NA NA +DTXSID9022861 Css 3compartmentss Human 95% 4.616 mg/L 3.608 mg/L 1.27937915742794 +DTXSID9022940 Css 3compartmentss Human 95% 1.087 mg/L 1.239 mg/L 0.877320419693301 +DTXSID9022944 Css 3compartmentss Human 95% 2.725 mg/L 1.482 mg/L 1.8387314439946 +DTXSID9022946 Css 3compartmentss Human 95% 2.743 mg/L 50.83 mg/L 0.0539641943734015 +DTXSID9022994 Css 3compartmentss Human 95% 20.45 mg/L 0.2914 mg/L 70.178448867536 +DTXSID9022998 Css 3compartmentss Human 95% 20.9 mg/L 5.497 mg/L 3.80207385846826 +DTXSID9023041 Css 3compartmentss Human 95% 0.3996 mg/L 0.4704 mg/L 0.849489795918367 +DTXSID9023043 Css 3compartmentss Human 95% 30.36 mg/L 59.34 mg/L 0.511627906976744 +DTXSID9023045 Css 3compartmentss Human 95% 27.84 mg/L 28.26 mg/L 0.985138004246284 +DTXSID9023049 Css 3compartmentss Human 95% 2.95 mg/L 6.777 mg/L 0.435295853622547 +DTXSID9023095 Css 3compartmentss Human 95% 10.3 mg/L 44.87 mg/L 0.229552039224426 +DTXSID9023097 Css 3compartmentss Human 95% 1.011 mg/L 53.16 mg/L 0.0190180586907449 +DTXSID9023122 Css 3compartmentss Human 95% 5.318 mg/L 8.416 mg/L 0.631891634980989 +DTXSID9023128 Css 3compartmentss Human 95% 1.553 mg/L 2.942 mg/L 0.52787219578518 +DTXSID9023170 Css 3compartmentss Human 95% 1.422 mg/L 0.4246 mg/L 3.34903438530382 +DTXSID9023174 Css 3compartmentss Human 95% 3.291 mg/L 0.9907 mg/L 3.32189361057838 +DTXSID9023176 Css 3compartmentss Human 95% 5.713 mg/L 5.647 mg/L 1.01168762174606 +DTXSID9023201 Css 3compartmentss Human 95% 14.29 mg/L 32.38 mg/L 0.441321803582458 +DTXSID9023205 Css 3compartmentss Human 95% 0.323 mg/L 7.69 mg/L 0.0420026007802341 +DTXSID9023207 Css 3compartmentss Human 95% 2.207 mg/L NA NA NA +DTXSID9023209 Css 3compartmentss Human 95% 3.63 mg/L 6.292 mg/L 0.576923076923077 +DTXSID9023253 Css 3compartmentss Human 95% 0.2765 mg/L NA NA NA +DTXSID9023255 Css 3compartmentss Human 95% 0.416 mg/L 0.1184 mg/L 3.51351351351351 +DTXSID9023259 Css 3compartmentss Human 95% 3.123 mg/L NA NA NA +DTXSID9023330 Css 3compartmentss Human 95% 1.612 mg/L NA NA NA +DTXSID9023334 Css 3compartmentss Human 95% 62.62 mg/L 39.97 mg/L 1.56667500625469 +DTXSID9023336 Css 3compartmentss Human 95% 0.2343 mg/L 0.3083 mg/L 0.759974051248784 +DTXSID9023338 Css 3compartmentss Human 95% 4.782 mg/L NA NA NA +DTXSID9023380 Css 3compartmentss Human 95% 60.45 mg/L 61.98 mg/L 0.975314617618587 +DTXSID9023384 Css 3compartmentss Human 95% 14.9 mg/L 21.63 mg/L 0.688858067498844 +DTXSID9023386 Css 3compartmentss Human 95% 1.365 mg/L 7 mg/L 0.195 +DTXSID9023388 Css 3compartmentss Human 95% 5.122 mg/L 3.111 mg/L 1.64641594342655 +DTXSID9023411 Css 3compartmentss Human 95% 20.86 mg/L 7.476 mg/L 2.79026217228464 +DTXSID9023413 Css 3compartmentss Human 95% 1.861 mg/L 0.07055 mg/L 26.3784549964564 +DTXSID9023415 Css 3compartmentss Human 95% 10.73 mg/L 1614 mg/L 0.00664807930607187 +DTXSID9023463 Css 3compartmentss Human 95% 7.784 mg/L 5.56 mg/L 1.4 +DTXSID9023540 Css 3compartmentss Human 95% 0.3453 mg/L 0.01147 mg/L 30.104620749782 +DTXSID9023542 Css 3compartmentss Human 95% 1.044 mg/L 0.7764 mg/L 1.34466769706337 +DTXSID9023546 Css 3compartmentss Human 95% 0.682 mg/L 0.5046 mg/L 1.35156559651209 +DTXSID9023548 Css 3compartmentss Human 95% 8.49 mg/L 0.431 mg/L 19.6983758700696 +DTXSID9023590 Css 3compartmentss Human 95% 8.169 mg/L 0.4711 mg/L 17.3402674591382 +DTXSID9023592 Css 3compartmentss Human 95% 5.806 mg/L NA NA NA +DTXSID9023621 Css 3compartmentss Human 95% 949.9 mg/L 1094 mg/L 0.868281535648994 +DTXSID9023623 Css 3compartmentss Human 95% 19.6 mg/L 10.52 mg/L 1.86311787072243 +DTXSID9023629 Css 3compartmentss Human 95% 4.051 mg/L 3.923 mg/L 1.03262809074688 +DTXSID9023671 Css 3compartmentss Human 95% 1.431 mg/L NA NA NA +DTXSID9023673 Css 3compartmentss Human 95% 19.01 mg/L 0.9996 mg/L 19.0176070428171 +DTXSID9023677 Css 3compartmentss Human 95% 0.8775 mg/L 8.911 mg/L 0.098473796431377 +DTXSID9023679 Css 3compartmentss Human 95% 0.7729 mg/L 0.2507 mg/L 3.08296769046669 +DTXSID9023702 Css 3compartmentss Human 95% 0.03794 mg/L 0.0491 mg/L 0.772708757637475 +DTXSID9023706 Css 3compartmentss Human 95% 2.147 mg/L 29.13 mg/L 0.073704085135599 +DTXSID9023752 Css 3compartmentss Human 95% 16.95 mg/L 18.07 mg/L 0.938018815716657 +DTXSID9023754 Css 3compartmentss Human 95% 19.35 mg/L NA NA NA +DTXSID9023756 Css 3compartmentss Human 95% 5.291 mg/L 2.079 mg/L 2.54497354497355 +DTXSID90238097 Css 3compartmentss Human 95% 0.3533 mg/L NA NA NA +DTXSID9023835 Css 3compartmentss Human 95% 1.5 mg/L 0.1029 mg/L 14.5772594752187 +DTXSID9023881 Css 3compartmentss Human 95% 143.2 mg/L 161.3 mg/L 0.887786732796032 +DTXSID9023889 Css 3compartmentss Human 95% 12.74 mg/L 9.05 mg/L 1.40773480662983 +DTXSID9023914 Css 3compartmentss Human 95% 5.698 mg/L 5.884 mg/L 0.968388851121686 +DTXSID9024063 Css 3compartmentss Human 95% 0.7759 mg/L 0.7956 mg/L 0.975238813474108 +DTXSID9024065 Css 3compartmentss Human 95% 7.005 mg/L 7.164 mg/L 0.977805695142379 +DTXSID90241748 Css 3compartmentss Human 95% 26.53 mg/L NA NA NA +DTXSID9024194 Css 3compartmentss Human 95% 5.254 mg/L 46.73 mg/L 0.112433126471218 +DTXSID90242053 Css 3compartmentss Human 95% 6.301 mg/L NA NA NA +DTXSID9024304 Css 3compartmentss Human 95% 7.996 mg/L 7.928 mg/L 1.00857719475278 +DTXSID9024431 Css 3compartmentss Human 95% 0.3626 mg/L 1.458 mg/L 0.248696844993141 +DTXSID9024481 Css 3compartmentss Human 95% 0.9438 mg/L 1.37 mg/L 0.688905109489051 +DTXSID9024483 Css 3compartmentss Human 95% 3.685 mg/L 1.67 mg/L 2.20658682634731 +DTXSID9024485 Css 3compartmentss Human 95% 0.648 mg/L 0.3676 mg/L 1.76278563656148 +DTXSID9024487 Css 3compartmentss Human 95% 1.319 mg/L 2.467 mg/L 0.534657478719092 +DTXSID9024489 Css 3compartmentss Human 95% 0.2349 mg/L 0.2331 mg/L 1.00772200772201 +DTXSID9024512 Css 3compartmentss Human 95% 0.7349 mg/L 1.017 mg/L 0.722615535889872 +DTXSID9024568 Css 3compartmentss Human 95% 0.9885 mg/L 5.767 mg/L 0.17140627709381 +DTXSID9024641 Css 3compartmentss Human 95% 1.495 mg/L 6.33 mg/L 0.236176935229068 +DTXSID9024691 Css 3compartmentss Human 95% 0.3418 mg/L NA NA NA +DTXSID9024699 Css 3compartmentss Human 95% 1.416 mg/L 0.1463 mg/L 9.67874231032126 +DTXSID9024724 Css 3compartmentss Human 95% 1.151 mg/L NA NA NA +DTXSID9024726 Css 3compartmentss Human 95% 4.937 mg/L 5.652 mg/L 0.873496107572541 +DTXSID9024770 Css 3compartmentss Human 95% 3.299 mg/L 48.93 mg/L 0.0674228489679133 +DTXSID9024772 Css 3compartmentss Human 95% 4.092 mg/L 85.06 mg/L 0.0481072184340465 +DTXSID9024809 Css 3compartmentss Human 95% 0.2753 mg/L 3.352 mg/L 0.0821300715990453 +DTXSID9024855 Css 3compartmentss Human 95% 0.3816 mg/L 0.4597 mg/L 0.830106591255166 +DTXSID9024930 Css 3compartmentss Human 95% 0.8282 mg/L 0.6861 mg/L 1.20711266579216 +DTXSID9024934 Css 3compartmentss Human 95% 5.488 mg/L 7.495 mg/L 0.732221480987325 +DTXSID9024980 Css 3compartmentss Human 95% 7.455 mg/L 273.5 mg/L 0.0272577696526508 +DTXSID9024986 Css 3compartmentss Human 95% 18.88 mg/L 65.64 mg/L 0.287629494210847 +DTXSID9025035 Css 3compartmentss Human 95% 1.156 mg/L 7.677 mg/L 0.150579653510486 +DTXSID9025037 Css 3compartmentss Human 95% 0.7948 mg/L 2.426 mg/L 0.327617477328936 +DTXSID9025085 Css 3compartmentss Human 95% 3.914 mg/L 4.638 mg/L 0.84389823199655 +DTXSID9025114 Css 3compartmentss Human 95% 15.57 mg/L 3.641 mg/L 4.27629772040648 +DTXSID9025164 Css 3compartmentss Human 95% 7.884 mg/L 6.867 mg/L 1.1480996068152 +DTXSID9025166 Css 3compartmentss Human 95% 7.011 mg/L 2.827 mg/L 2.48001414927485 +DTXSID9025245 Css 3compartmentss Human 95% 12.09 mg/L 4858 mg/L 0.00248867846850556 +DTXSID9025249 Css 3compartmentss Human 95% 10.05 mg/L NA NA NA +DTXSID9025293 Css 3compartmentss Human 95% 6.553 mg/L 6.717 mg/L 0.975584338246241 +DTXSID9025299 Css 3compartmentss Human 95% 19.78 mg/L 13.78 mg/L 1.43541364296081 +DTXSID9025324 Css 3compartmentss Human 95% 2.336 mg/L NA NA NA +DTXSID9025328 Css 3compartmentss Human 95% 25.46 mg/L 21.04 mg/L 1.21007604562738 +DTXSID9025370 Css 3compartmentss Human 95% 2.186 mg/L 119.4 mg/L 0.0183082077051926 +DTXSID9025401 Css 3compartmentss Human 95% 0.8566 mg/L 13.08 mg/L 0.0654892966360856 +DTXSID9025403 Css 3compartmentss Human 95% 17.55 mg/L NA NA NA +DTXSID9025409 Css 3compartmentss Human 95% 1.563 mg/L 6.053 mg/L 0.258219064926483 +DTXSID9025451 Css 3compartmentss Human 95% 8.45 mg/L NA NA NA +DTXSID9025455 Css 3compartmentss Human 95% 0.388 mg/L 5.999 mg/L 0.0646774462410402 +DTXSID9025536 Css 3compartmentss Human 95% 5.66 mg/L 5.742 mg/L 0.985719261581331 +DTXSID9025538 Css 3compartmentss Human 95% 7.082 mg/L 3.892 mg/L 1.81963001027749 +DTXSID9025588 Css 3compartmentss Human 95% 0.7793 mg/L 6.648 mg/L 0.117223225030084 +DTXSID9025613 Css 3compartmentss Human 95% 6.014 mg/L NA NA NA +DTXSID9025617 Css 3compartmentss Human 95% 6.808 mg/L 2.349 mg/L 2.8982545764155 +DTXSID9025665 Css 3compartmentss Human 95% 8.409 mg/L 5.078 mg/L 1.6559669161087 +DTXSID9025740 Css 3compartmentss Human 95% 2.312 mg/L 3.056 mg/L 0.756544502617801 +DTXSID9025742 Css 3compartmentss Human 95% 1.918 mg/L 10.74 mg/L 0.178584729981378 +DTXSID9025744 Css 3compartmentss Human 95% 2.1 mg/L 2.319 mg/L 0.905562742561449 +DTXSID9025746 Css 3compartmentss Human 95% 12.74 mg/L 42.72 mg/L 0.298220973782772 +DTXSID9025825 Css 3compartmentss Human 95% 3.356 mg/L 0.08751 mg/L 38.3499028682436 +DTXSID9025873 Css 3compartmentss Human 95% 8.522 mg/L 10.86 mg/L 0.784714548802947 +DTXSID9025879 Css 3compartmentss Human 95% 2.679 mg/L 51.27 mg/L 0.0522527794031597 +DTXSID9026053 Css 3compartmentss Human 95% 0.1642 mg/L 0.2154 mg/L 0.76230269266481 +DTXSID9026059 Css 3compartmentss Human 95% 4.405 mg/L 5.202 mg/L 0.846789696270665 +DTXSID9026132 Css 3compartmentss Human 95% 0.008711 mg/L 0.01054 mg/L 0.826470588235294 +DTXSID9026219 Css 3compartmentss Human 95% 3.074 mg/L 454.9 mg/L 0.00675752912728072 +DTXSID9026261 Css 3compartmentss Human 95% 71.47 mg/L 74.12 mg/L 0.964247166756611 +DTXSID9026265 Css 3compartmentss Human 95% 19.43 mg/L 0.1415 mg/L 137.314487632509 +DTXSID9026342 Css 3compartmentss Human 95% 0.3939 mg/L 1.164 mg/L 0.33840206185567 +DTXSID9026558 Css 3compartmentss Human 95% 1.099 mg/L 0.9261 mg/L 1.18669690098262 +DTXSID9026631 Css 3compartmentss Human 95% 1.641 mg/L 1.137 mg/L 1.44327176781003 +DTXSID9026633 Css 3compartmentss Human 95% 0.2993 mg/L 1.928 mg/L 0.155238589211618 +DTXSID9026689 Css 3compartmentss Human 95% 3.823 mg/L 6.282 mg/L 0.608564151544094 +DTXSID9026712 Css 3compartmentss Human 95% 0.4281 mg/L 6.28 mg/L 0.0681687898089172 +DTXSID9026716 Css 3compartmentss Human 95% 5.381 mg/L 5.441 mg/L 0.988972615328065 +DTXSID9026718 Css 3compartmentss Human 95% 6.74 mg/L 8.04 mg/L 0.838308457711443 +DTXSID9026841 Css 3compartmentss Human 95% 10.95 mg/L 16.26 mg/L 0.673431734317343 +DTXSID9026849 Css 3compartmentss Human 95% 5.009 mg/L 4.909 mg/L 1.02037074760644 +DTXSID9026899 Css 3compartmentss Human 95% 1.367 mg/L 1.542 mg/L 0.88651102464332 +DTXSID9026922 Css 3compartmentss Human 95% 6.894 mg/L 3.173 mg/L 2.17270721714466 +DTXSID9026974 Css 3compartmentss Human 95% 19.97 mg/L 7.082 mg/L 2.81982490821802 +DTXSID9027021 Css 3compartmentss Human 95% 0.3809 mg/L 8.029 mg/L 0.0474405280856894 +DTXSID9027025 Css 3compartmentss Human 95% 7.357 mg/L NA NA NA +DTXSID9027158 Css 3compartmentss Human 95% 0.7818 mg/L 1.38 mg/L 0.566521739130435 +DTXSID9027233 Css 3compartmentss Human 95% 6.228 mg/L 7.396 mg/L 0.842076798269335 +DTXSID9027239 Css 3compartmentss Human 95% 33.29 mg/L 34.94 mg/L 0.952776187750429 +DTXSID9027281 Css 3compartmentss Human 95% 2.841 mg/L 34.29 mg/L 0.0828521434820648 +DTXSID9027312 Css 3compartmentss Human 95% 0.4241 mg/L 0.2916 mg/L 1.45438957475994 +DTXSID9027314 Css 3compartmentss Human 95% 5.072 mg/L 7.099 mg/L 0.714466826313565 +DTXSID9027360 Css 3compartmentss Human 95% 7.038 mg/L 8.057 mg/L 0.873526126349758 +DTXSID9027364 Css 3compartmentss Human 95% 0.633 mg/L NA NA NA +DTXSID9027368 Css 3compartmentss Human 95% 0.6349 mg/L 1.371 mg/L 0.463092633114515 +DTXSID90274238 Css 3compartmentss Human 95% 7.343 mg/L NA NA NA +DTXSID9027441 Css 3compartmentss Human 95% 0.6538 mg/L 0.6192 mg/L 1.05587855297158 +DTXSID9027443 Css 3compartmentss Human 95% 7.242 mg/L 3.148 mg/L 2.3005082592122 +DTXSID9027520 Css 3compartmentss Human 95% 0.8664 mg/L 0.1306 mg/L 6.63399693721286 +DTXSID9027522 Css 3compartmentss Human 95% 57.82 mg/L 27.57 mg/L 2.09720710917664 +DTXSID9027570 Css 3compartmentss Human 95% 0.3257 mg/L 4.978 mg/L 0.0654278826838088 +DTXSID9027603 Css 3compartmentss Human 95% 8.517 mg/L 1.271 mg/L 6.70102281667978 +DTXSID9027653 Css 3compartmentss Human 95% 16.03 mg/L NA NA NA +DTXSID9029146 Css 3compartmentss Human 95% 4.724 mg/L 5.508 mg/L 0.857661583151779 +DTXSID9029221 Css 3compartmentss Human 95% 1.78 mg/L 1.708 mg/L 1.04215456674473 +DTXSID9029225 Css 3compartmentss Human 95% 6.369 mg/L 5.274 mg/L 1.20762229806598 +DTXSID9029227 Css 3compartmentss Human 95% 11.13 mg/L NA NA NA +DTXSID9029275 Css 3compartmentss Human 95% 7.914 mg/L 4.662 mg/L 1.6975546975547 +DTXSID9029277 Css 3compartmentss Human 95% 4.324 mg/L NA NA NA +DTXSID9029279 Css 3compartmentss Human 95% 8.274 mg/L 9.51 mg/L 0.870031545741325 +DTXSID9029302 Css 3compartmentss Human 95% 6.64 mg/L 6.618 mg/L 1.0033242671502 +DTXSID90296016 Css 3compartmentss Human 95% 1.367 mg/L NA NA NA +DTXSID9029649 Css 3compartmentss Human 95% 6.553 mg/L 0.7146 mg/L 9.17016512734397 +DTXSID9030048 Css 3compartmentss Human 95% 2817 mg/L NA NA NA +DTXSID9030707 Css 3compartmentss Human 95% 9.395 mg/L 10.41 mg/L 0.902497598463016 +DTXSID90311733 Css 3compartmentss Human 95% 16.42 mg/L NA NA NA +DTXSID9031800 Css 3compartmentss Human 95% 8.843 mg/L 4.257 mg/L 2.07728447263331 +DTXSID9032113 Css 3compartmentss Human 95% 16.69 mg/L 16.96 mg/L 0.984080188679245 +DTXSID9032327 Css 3compartmentss Human 95% 0.8132 mg/L 0.7933 mg/L 1.02508508760872 +DTXSID9032329 Css 3compartmentss Human 95% 2.411 mg/L 2.694 mg/L 0.894951744617669 +DTXSID9032375 Css 3compartmentss Human 95% 2.529 mg/L 205.7 mg/L 0.01229460379193 +DTXSID9032379 Css 3compartmentss Human 95% 33.93 mg/L 30.38 mg/L 1.11685319289006 +DTXSID9032406 Css 3compartmentss Human 95% 5.609 mg/L 7.005 mg/L 0.800713775874375 +DTXSID9032531 Css 3compartmentss Human 95% 3.075 mg/L 10.82 mg/L 0.284195933456562 +DTXSID9032533 Css 3compartmentss Human 95% 16.14 mg/L 46.25 mg/L 0.348972972972973 +DTXSID9032535 Css 3compartmentss Human 95% 3.662 mg/L 3.723 mg/L 0.983615363953801 +DTXSID9032581 Css 3compartmentss Human 95% 629.8 mg/L 707.2 mg/L 0.890554298642534 +DTXSID9032589 Css 3compartmentss Human 95% 84.92 mg/L 168.1 mg/L 0.505175490779298 +DTXSID9032610 Css 3compartmentss Human 95% 8.024 mg/L 0.7466 mg/L 10.7473881596571 +DTXSID9032878 Css 3compartmentss Human 95% 5.629 mg/L 2.949 mg/L 1.90878263818243 +DTXSID9033008 Css 3compartmentss Human 95% 2.016 mg/L 21.93 mg/L 0.0919288645690834 +DTXSID9033058 Css 3compartmentss Human 95% 2.26 mg/L 2.734 mg/L 0.826627651792246 +DTXSID9033187 Css 3compartmentss Human 95% 1.545 mg/L 1.106 mg/L 1.39692585895118 +DTXSID90334987 Css 3compartmentss Human 95% 1.97 mg/L NA NA NA +DTXSID90338228 Css 3compartmentss Human 95% 0.4453 mg/L NA NA NA +DTXSID9033923 Css 3compartmentss Human 95% 11.75 mg/L 11.89 mg/L 0.988225399495374 +DTXSID9033979 Css 3compartmentss Human 95% 51.21 mg/L 45.32 mg/L 1.12996469549868 +DTXSID9034232 Css 3compartmentss Human 95% 297.8 mg/L 306.5 mg/L 0.971615008156607 +DTXSID9034282 Css 3compartmentss Human 95% 38.19 mg/L 13.11 mg/L 2.91304347826087 +DTXSID9034286 Css 3compartmentss Human 95% 7.269 mg/L 1.631 mg/L 4.45677498467198 +DTXSID9034361 Css 3compartmentss Human 95% 3.79 mg/L 358.5 mg/L 0.0105718270571827 +DTXSID9034365 Css 3compartmentss Human 95% 3.552 mg/L 13.02 mg/L 0.272811059907834 +DTXSID9034490 Css 3compartmentss Human 95% 7.312 mg/L 8.118 mg/L 0.900714461690071 +DTXSID9034492 Css 3compartmentss Human 95% 4.712 mg/L 5.089 mg/L 0.925918648064453 +DTXSID9034496 Css 3compartmentss Human 95% 6.606 mg/L NA NA NA +DTXSID9034573 Css 3compartmentss Human 95% 384.2 mg/L 435.8 mg/L 0.881597062872877 +DTXSID9034650 Css 3compartmentss Human 95% 538.5 mg/L 718.4 mg/L 0.749582405345212 +DTXSID90346601 Css 3compartmentss Human 95% 7.576 mg/L NA NA NA +DTXSID9034816 Css 3compartmentss Human 95% 0.7416 mg/L 0.7865 mg/L 0.942911633820725 +DTXSID9034818 Css 3compartmentss Human 95% 0.007339 mg/L 0.01186 mg/L 0.618802698145025 +DTXSID9034864 Css 3compartmentss Human 95% 53.78 mg/L 131.2 mg/L 0.409908536585366 +DTXSID9034868 Css 3compartmentss Human 95% 0.5448 mg/L NA NA NA +DTXSID90349379 Css 3compartmentss Human 95% 2.358 mg/L NA NA NA +DTXSID9035175 Css 3compartmentss Human 95% 7.074 mg/L 1.084 mg/L 6.52583025830258 +DTXSID9035620 Css 3compartmentss Human 95% 0.6042 mg/L 9.115 mg/L 0.066286341195831 +DTXSID9035753 Css 3compartmentss Human 95% 6.942 mg/L 0.5461 mg/L 12.7119575169383 +DTXSID9036226 Css 3compartmentss Human 95% 7.864 mg/L 3.092 mg/L 2.54333764553687 +DTXSID90363979 Css 3compartmentss Human 95% 0.9059 mg/L NA NA NA +DTXSID9036438 Css 3compartmentss Human 95% 15.22 mg/L 9.433 mg/L 1.61348457542669 +DTXSID9036515 Css 3compartmentss Human 95% 13.63 mg/L 21.05 mg/L 0.64750593824228 +DTXSID9036646 Css 3compartmentss Human 95% 0.4125 mg/L 8.247 mg/L 0.0500181884321571 +DTXSID9036690 Css 3compartmentss Human 95% 0.1976 mg/L 0.1395 mg/L 1.41648745519713 +DTXSID9037038 Css 3compartmentss Human 95% 2.216 mg/L 2.201 mg/L 1.0068150840527 +DTXSID9037246 Css 3compartmentss Human 95% 4.227 mg/L 4.946 mg/L 0.854630004043672 +DTXSID9037248 Css 3compartmentss Human 95% 0.9805 mg/L 0.03841 mg/L 25.5272064566519 +DTXSID90373412 Css 3compartmentss Human 95% 3.498 mg/L NA NA NA +DTXSID9037535 Css 3compartmentss Human 95% 0.6306 mg/L 0.1132 mg/L 5.57067137809187 +DTXSID9037539 Css 3compartmentss Human 95% 11.49 mg/L 11.55 mg/L 0.994805194805195 +DTXSID9037612 Css 3compartmentss Human 95% 2.682 mg/L 2.8 mg/L 0.957857142857143 +DTXSID9037616 Css 3compartmentss Human 95% 7.443 mg/L 3.925 mg/L 1.89630573248408 +DTXSID9037741 Css 3compartmentss Human 95% 1.522 mg/L 1.469 mg/L 1.03607896528251 +DTXSID9037745 Css 3compartmentss Human 95% 15.82 mg/L 2.239 mg/L 7.0656543099598 +DTXSID9037749 Css 3compartmentss Human 95% 18.1 mg/L 9.462 mg/L 1.91291481716339 +DTXSID9038686 Css 3compartmentss Human 95% 2.594 mg/L 34.8 mg/L 0.0745402298850575 +DTXSID9039232 Css 3compartmentss Human 95% 5.905 mg/L NA NA NA +DTXSID9039238 Css 3compartmentss Human 95% 8.142 mg/L 3.306 mg/L 2.46279491833031 +DTXSID9040001 Css 3compartmentss Human 95% 4.384 mg/L 5.797 mg/L 0.756253234431603 +DTXSID9040130 Css 3compartmentss Human 95% 1.858 mg/L 1.074 mg/L 1.72998137802607 +DTXSID9040132 Css 3compartmentss Human 95% 2.8 mg/L NA NA NA +DTXSID9040134 Css 3compartmentss Human 95% 0.7957 mg/L 2.914 mg/L 0.273061084420041 +DTXSID9040215 Css 3compartmentss Human 95% 1.909 mg/L 1.903 mg/L 1.00315291644771 +DTXSID9040265 Css 3compartmentss Human 95% 13.03 mg/L 4.412 mg/L 2.95330915684497 +DTXSID9040269 Css 3compartmentss Human 95% 19.38 mg/L 0.8941 mg/L 21.6754278044961 +DTXSID9040342 Css 3compartmentss Human 95% 0.2556 mg/L 5.573 mg/L 0.045863987080567 +DTXSID9040502 Css 3compartmentss Human 95% 1.321 mg/L 2.33 mg/L 0.566952789699571 +DTXSID9040554 Css 3compartmentss Human 95% 1.233 mg/L 1.281 mg/L 0.962529274004684 +DTXSID9040556 Css 3compartmentss Human 95% 3.533 mg/L NA NA NA +DTXSID9040635 Css 3compartmentss Human 95% 1.398 mg/L 2.599 mg/L 0.537899191996922 +DTXSID9040683 Css 3compartmentss Human 95% 5.301 mg/L 3.112 mg/L 1.70340616966581 +DTXSID9040685 Css 3compartmentss Human 95% 0.2577 mg/L 5.402 mg/L 0.0477045538689374 +DTXSID9040687 Css 3compartmentss Human 95% 35.09 mg/L 39.21 mg/L 0.894924764090793 +DTXSID9040714 Css 3compartmentss Human 95% 2.394 mg/L 4.772 mg/L 0.501676445934619 +DTXSID9040716 Css 3compartmentss Human 95% 2.722 mg/L 33.85 mg/L 0.0804135893648449 +DTXSID9040718 Css 3compartmentss Human 95% 11.63 mg/L 0.06355 mg/L 183.00550747443 +DTXSID9040760 Css 3compartmentss Human 95% 9.402 mg/L NA NA NA +DTXSID9040766 Css 3compartmentss Human 95% 0.2565 mg/L NA NA NA +DTXSID9041021 Css 3compartmentss Human 95% 4.345 mg/L 5.294 mg/L 0.820740460899131 +DTXSID9041023 Css 3compartmentss Human 95% 16.89 mg/L 8.791 mg/L 1.92128313047435 +DTXSID9041104 Css 3compartmentss Human 95% 5.733 mg/L 5.576 mg/L 1.02815638450502 +DTXSID9041152 Css 3compartmentss Human 95% 2.132 mg/L 2.434 mg/L 0.875924404272802 +DTXSID9041233 Css 3compartmentss Human 95% 36.87 mg/L 41.26 mg/L 0.893601551139118 +DTXSID9041362 Css 3compartmentss Human 95% 2.477 mg/L 4.772 mg/L 0.519069572506287 +DTXSID9041366 Css 3compartmentss Human 95% 1.675 mg/L 0.3508 mg/L 4.77480045610034 +DTXSID9041368 Css 3compartmentss Human 95% 5.543 mg/L 5.481 mg/L 1.01131180441525 +DTXSID9041441 Css 3compartmentss Human 95% 0.7757 mg/L 14.49 mg/L 0.0535334713595583 +DTXSID9041491 Css 3compartmentss Human 95% 0.6047 mg/L 1.11 mg/L 0.544774774774775 +DTXSID9041520 Css 3compartmentss Human 95% 0.5914 mg/L 1.042 mg/L 0.567562380038388 +DTXSID9041528 Css 3compartmentss Human 95% 0.3654 mg/L 1.205 mg/L 0.303236514522822 +DTXSID9041570 Css 3compartmentss Human 95% 5.08 mg/L 5.681 mg/L 0.894208766062313 +DTXSID9041607 Css 3compartmentss Human 95% 0.9453 mg/L 0.5851 mg/L 1.61562126132285 +DTXSID9041653 Css 3compartmentss Human 95% 0.5174 mg/L 0.5233 mg/L 0.988725396522071 +DTXSID9041659 Css 3compartmentss Human 95% 20.35 mg/L 21.14 mg/L 0.962630085146642 +DTXSID9041813 Css 3compartmentss Human 95% 0.4089 mg/L 2.133 mg/L 0.191701828410689 +DTXSID9041815 Css 3compartmentss Human 95% 0.9491 mg/L 2.311 mg/L 0.41068801384682 +DTXSID9041861 Css 3compartmentss Human 95% 6.216 mg/L 5.986 mg/L 1.0384229869696 +DTXSID9042093 Css 3compartmentss Human 95% 9.913 mg/L NA NA NA +DTXSID9042097 Css 3compartmentss Human 95% 2.429 mg/L NA NA NA +DTXSID9042170 Css 3compartmentss Human 95% 0.5081 mg/L 0.5492 mg/L 0.925163874726875 +DTXSID9042259 Css 3compartmentss Human 95% 6.595 mg/L 11.74 mg/L 0.56175468483816 +DTXSID9042336 Css 3compartmentss Human 95% 0.2318 mg/L 3.361 mg/L 0.0689675691758405 +DTXSID9042382 Css 3compartmentss Human 95% 4.475 mg/L 1.572 mg/L 2.84669211195929 +DTXSID9042415 Css 3compartmentss Human 95% 0.1308 mg/L 7.666 mg/L 0.0170623532481085 +DTXSID90424897 Css 3compartmentss Human 95% 2.179 mg/L NA NA NA +DTXSID9042592 Css 3compartmentss Human 95% 3.923 mg/L 2.509 mg/L 1.56357114388202 +DTXSID9042594 Css 3compartmentss Human 95% 19.2 mg/L 6.545 mg/L 2.93353705118411 +DTXSID90430791 Css 3compartmentss Human 95% 1.028 mg/L NA NA NA +DTXSID90432396 Css 3compartmentss Human 95% 1.895 mg/L NA NA NA +DTXSID90433025 Css 3compartmentss Human 95% 5.745 mg/L NA NA NA +DTXSID9043774 Css 3compartmentss Human 95% 11.84 mg/L NA NA NA +DTXSID9043853 Css 3compartmentss Human 95% 1.223 mg/L 1.441 mg/L 0.848716169326856 +DTXSID9043855 Css 3compartmentss Human 95% 1.205 mg/L 25.8 mg/L 0.0467054263565891 +DTXSID9043938 Css 3compartmentss Human 95% 130.5 mg/L 137 mg/L 0.952554744525547 +DTXSID9043988 Css 3compartmentss Human 95% 10.7 mg/L 0.7178 mg/L 14.9066592365561 +DTXSID9044112 Css 3compartmentss Human 95% 11.09 mg/L 4.595 mg/L 2.41349292709467 +DTXSID9044164 Css 3compartmentss Human 95% 11.14 mg/L 2.307 mg/L 4.82878196792371 +DTXSID9044241 Css 3compartmentss Human 95% 7.835 mg/L 8.763 mg/L 0.894100193997489 +DTXSID9044247 Css 3compartmentss Human 95% 3.034 mg/L 3.502 mg/L 0.866362078812107 +DTXSID9044297 Css 3compartmentss Human 95% 7.007 mg/L NA NA NA +DTXSID9044299 Css 3compartmentss Human 95% 4.703 mg/L 8.526 mg/L 0.551606849636406 +DTXSID9044320 Css 3compartmentss Human 95% 3.076 mg/L 3.764 mg/L 0.81721572794899 +DTXSID9044328 Css 3compartmentss Human 95% 10.85 mg/L 12.36 mg/L 0.877831715210356 +DTXSID9044370 Css 3compartmentss Human 95% 4.056 mg/L 4.034 mg/L 1.00545364402578 +DTXSID9044372 Css 3compartmentss Human 95% 0.04036 mg/L 0.04128 mg/L 0.977713178294574 +DTXSID9044378 Css 3compartmentss Human 95% 3.166 mg/L 23.79 mg/L 0.133081126523749 +DTXSID9044401 Css 3compartmentss Human 95% 0.3722 mg/L 1.472 mg/L 0.252853260869565 +DTXSID9044403 Css 3compartmentss Human 95% 1.208 mg/L 0.4996 mg/L 2.41793434747798 +DTXSID9044405 Css 3compartmentss Human 95% 4.266 mg/L 4.877 mg/L 0.874718064383843 +DTXSID9044407 Css 3compartmentss Human 95% 7.874 mg/L 0.9404 mg/L 8.37303275202042 +DTXSID9044451 Css 3compartmentss Human 95% 5.842 mg/L 6.985 mg/L 0.836363636363636 +DTXSID9044455 Css 3compartmentss Human 95% 6.338 mg/L 26.28 mg/L 0.24117199391172 +DTXSID9044459 Css 3compartmentss Human 95% 54.91 mg/L 255.5 mg/L 0.214911937377691 +DTXSID9044532 Css 3compartmentss Human 95% 0.104 mg/L 7.415 mg/L 0.0140256237356709 +DTXSID9044534 Css 3compartmentss Human 95% 0.4999 mg/L 0.9592 mg/L 0.521163469557965 +DTXSID9044536 Css 3compartmentss Human 95% 21.4 mg/L 46.52 mg/L 0.460017196904557 +DTXSID9044538 Css 3compartmentss Human 95% 2484 mg/L 2649 mg/L 0.937712344280861 +DTXSID9044582 Css 3compartmentss Human 95% 17.61 mg/L 21.06 mg/L 0.836182336182336 +DTXSID9044584 Css 3compartmentss Human 95% 0.4167 mg/L NA NA NA +DTXSID9044588 Css 3compartmentss Human 95% 0.3958 mg/L 7.103 mg/L 0.0557229339715613 +DTXSID9044611 Css 3compartmentss Human 95% 1.375 mg/L 14.54 mg/L 0.094566712517194 +DTXSID9044613 Css 3compartmentss Human 95% 2.714 mg/L 26.5 mg/L 0.102415094339623 +DTXSID9044615 Css 3compartmentss Human 95% 6.919 mg/L 2.685 mg/L 2.57690875232775 +DTXSID9044619 Css 3compartmentss Human 95% 0.2008 mg/L NA NA NA +DTXSID9044661 Css 3compartmentss Human 95% 17.45 mg/L 27.55 mg/L 0.633393829401089 +DTXSID9044663 Css 3compartmentss Human 95% 7.017 mg/L 269.9 mg/L 0.0259985179696184 +DTXSID9044667 Css 3compartmentss Human 95% 6.57 mg/L 0.04533 mg/L 144.93712772998 +DTXSID9044740 Css 3compartmentss Human 95% 0.5555 mg/L 0.2404 mg/L 2.31073211314476 +DTXSID9044742 Css 3compartmentss Human 95% 7.116 mg/L 0.08508 mg/L 83.638928067701 +DTXSID9044744 Css 3compartmentss Human 95% 4.863 mg/L 1.426 mg/L 3.41023842917251 +DTXSID9044746 Css 3compartmentss Human 95% 1.671 mg/L NA NA NA +DTXSID9044748 Css 3compartmentss Human 95% 1.628 mg/L 3.162 mg/L 0.514864010120177 +DTXSID9044790 Css 3compartmentss Human 95% 10.62 mg/L 6.055 mg/L 1.75392237819983 +DTXSID9044794 Css 3compartmentss Human 95% 1.029 mg/L 4.016 mg/L 0.256225099601594 +DTXSID9044798 Css 3compartmentss Human 95% 9.985 mg/L NA NA NA +DTXSID9044821 Css 3compartmentss Human 95% 3.878 mg/L 3.708 mg/L 1.04584681769148 +DTXSID9044823 Css 3compartmentss Human 95% 6.769 mg/L 7.817 mg/L 0.865933222463861 +DTXSID9044825 Css 3compartmentss Human 95% 1.229 mg/L 1.278 mg/L 0.961658841940532 +DTXSID9044827 Css 3compartmentss Human 95% 0.2676 mg/L 0.07047 mg/L 3.79736057896977 +DTXSID9044829 Css 3compartmentss Human 95% 20.12 mg/L 11.25 mg/L 1.78844444444444 +DTXSID9044871 Css 3compartmentss Human 95% 1.822 mg/L NA NA NA +DTXSID9044875 Css 3compartmentss Human 95% 5.833 mg/L 4.056 mg/L 1.43811637080868 +DTXSID9044877 Css 3compartmentss Human 95% 0.3415 mg/L 0.4227 mg/L 0.807901585048498 +DTXSID9044879 Css 3compartmentss Human 95% 5.899 mg/L 7.655 mg/L 0.770607446113651 +DTXSID9044908 Css 3compartmentss Human 95% 8.116 mg/L 7.209 mg/L 1.12581495353031 +DTXSID9044950 Css 3compartmentss Human 95% 556.2 mg/L 583.3 mg/L 0.953540202297274 +DTXSID9045003 Css 3compartmentss Human 95% 1.25 mg/L 3.813 mg/L 0.32782585890375 +DTXSID9045132 Css 3compartmentss Human 95% 6.108 mg/L 102.8 mg/L 0.0594163424124514 +DTXSID9045136 Css 3compartmentss Human 95% 1.051 mg/L 6.581 mg/L 0.159702172922048 +DTXSID9045138 Css 3compartmentss Human 95% 0.3605 mg/L 0.2825 mg/L 1.27610619469027 +DTXSID9045180 Css 3compartmentss Human 95% 6.167 mg/L 5.301 mg/L 1.1633654027542 +DTXSID9045182 Css 3compartmentss Human 95% 4.409 mg/L 1.466 mg/L 3.0075034106412 +DTXSID9045184 Css 3compartmentss Human 95% 3.582 mg/L 0.6598 mg/L 5.42891785389512 +DTXSID9045186 Css 3compartmentss Human 95% 8.246 mg/L 7.579 mg/L 1.08800633328935 +DTXSID9045188 Css 3compartmentss Human 95% 0.9756 mg/L 1.155 mg/L 0.844675324675325 +DTXSID9045215 Css 3compartmentss Human 95% 12.03 mg/L 9.098 mg/L 1.32226863046823 +DTXSID9045217 Css 3compartmentss Human 95% 5.063 mg/L 16.69 mg/L 0.303355302576393 +DTXSID9045265 Css 3compartmentss Human 95% 5.63 mg/L 17.58 mg/L 0.320250284414107 +DTXSID9045267 Css 3compartmentss Human 95% 2.076 mg/L 2.172 mg/L 0.955801104972376 +DTXSID9045342 Css 3compartmentss Human 95% 4.914 mg/L 5.25 mg/L 0.936 +DTXSID9045344 Css 3compartmentss Human 95% 7.467 mg/L 6.989 mg/L 1.06839318929747 +DTXSID9045346 Css 3compartmentss Human 95% 1.286 mg/L 1.892 mg/L 0.679704016913319 +DTXSID9045348 Css 3compartmentss Human 95% 3.757 mg/L 14.31 mg/L 0.262543675751223 +DTXSID9045390 Css 3compartmentss Human 95% 0.8888 mg/L 0.474 mg/L 1.87510548523207 +DTXSID9045392 Css 3compartmentss Human 95% 7.999 mg/L 0.1294 mg/L 61.8160741885626 +DTXSID9045394 Css 3compartmentss Human 95% 3.862 mg/L 6.624 mg/L 0.583031400966184 +DTXSID9045398 Css 3compartmentss Human 95% 6.319 mg/L 0.2539 mg/L 24.8877510831036 +DTXSID9045425 Css 3compartmentss Human 95% 1.924 mg/L 0.6765 mg/L 2.8440502586844 +DTXSID9045429 Css 3compartmentss Human 95% 5.799 mg/L 1.085 mg/L 5.34470046082949 +DTXSID9045479 Css 3compartmentss Human 95% 6.564 mg/L 0.8937 mg/L 7.34474655924807 +DTXSID9045500 Css 3compartmentss Human 95% 1.441 mg/L 2.09 mg/L 0.689473684210526 +DTXSID9045502 Css 3compartmentss Human 95% 2.306 mg/L 2.575 mg/L 0.895533980582524 +DTXSID9045506 Css 3compartmentss Human 95% 1.738 mg/L 22.27 mg/L 0.0780422092501123 +DTXSID9045508 Css 3compartmentss Human 95% 3.154 mg/L 4.06 mg/L 0.776847290640394 +DTXSID9045550 Css 3compartmentss Human 95% 4.561 mg/L 9.031 mg/L 0.505038201749529 +DTXSID9045552 Css 3compartmentss Human 95% 12.15 mg/L 343.1 mg/L 0.035412416205188 +DTXSID9045556 Css 3compartmentss Human 95% 0.9903 mg/L 1.317 mg/L 0.751936218678815 +DTXSID9045558 Css 3compartmentss Human 95% 1.874 mg/L 7.762 mg/L 0.241432620458645 +DTXSID9045631 Css 3compartmentss Human 95% 26.48 mg/L 13.33 mg/L 1.98649662415604 +DTXSID9045633 Css 3compartmentss Human 95% 4.592 mg/L 1.594 mg/L 2.88080301129235 +DTXSID9045635 Css 3compartmentss Human 95% 1.62 mg/L 5.978 mg/L 0.270993643358983 +DTXSID9045637 Css 3compartmentss Human 95% 1.016 mg/L 7.557 mg/L 0.134444885536589 +DTXSID9045639 Css 3compartmentss Human 95% 1.534 mg/L 7.088 mg/L 0.216422121896163 +DTXSID9045683 Css 3compartmentss Human 95% 0.5255 mg/L 0.4245 mg/L 1.2379269729093 +DTXSID9045685 Css 3compartmentss Human 95% 1.641 mg/L 17.11 mg/L 0.0959088252483928 +DTXSID9045687 Css 3compartmentss Human 95% 11.35 mg/L 24.84 mg/L 0.456924315619968 +DTXSID9045689 Css 3compartmentss Human 95% 10.88 mg/L 3.621 mg/L 3.00469483568075 +DTXSID9045710 Css 3compartmentss Human 95% 1.479 mg/L 0.49 mg/L 3.01836734693878 +DTXSID9045762 Css 3compartmentss Human 95% 0.7046 mg/L 0.103 mg/L 6.84077669902913 +DTXSID9045764 Css 3compartmentss Human 95% 0.7414 mg/L 9.571 mg/L 0.0774631699926862 +DTXSID9045768 Css 3compartmentss Human 95% 1.021 mg/L 0.9059 mg/L 1.12705596644221 +DTXSID9045843 Css 3compartmentss Human 95% 0.3552 mg/L 0.1654 mg/L 2.14752116082225 +DTXSID9045849 Css 3compartmentss Human 95% 18.95 mg/L 194.3 mg/L 0.0975295934122491 +DTXSID9045891 Css 3compartmentss Human 95% 6.259 mg/L 4.749 mg/L 1.31796167614235 +DTXSID9045895 Css 3compartmentss Human 95% 6.199 mg/L 309 mg/L 0.0200614886731392 +DTXSID9045897 Css 3compartmentss Human 95% 5.603 mg/L 6.144 mg/L 0.911946614583333 +DTXSID9045899 Css 3compartmentss Human 95% 2.298 mg/L 3.965 mg/L 0.579571248423707 +DTXSID9045922 Css 3compartmentss Human 95% 0.7826 mg/L 58.33 mg/L 0.0134167666723813 +DTXSID9045924 Css 3compartmentss Human 95% 3.473 mg/L 124.9 mg/L 0.0278062449959968 +DTXSID9045928 Css 3compartmentss Human 95% 7.89 mg/L 32.6 mg/L 0.242024539877301 +DTXSID9045976 Css 3compartmentss Human 95% 1.575 mg/L 10.94 mg/L 0.143967093235832 +DTXSID9045978 Css 3compartmentss Human 95% 2.281 mg/L 0.08837 mg/L 25.8119271245898 +DTXSID9046023 Css 3compartmentss Human 95% 1.403 mg/L 1.224 mg/L 1.14624183006536 +DTXSID9046029 Css 3compartmentss Human 95% 13.92 mg/L 62.67 mg/L 0.222115844901867 +DTXSID9046071 Css 3compartmentss Human 95% 0.9858 mg/L 5.289 mg/L 0.186386840612592 +DTXSID9046073 Css 3compartmentss Human 95% 6.025 mg/L 6.808 mg/L 0.884988249118684 +DTXSID9046100 Css 3compartmentss Human 95% 0.4493 mg/L 0.9643 mg/L 0.465933838017214 +DTXSID9046102 Css 3compartmentss Human 95% 4.279 mg/L 10.47 mg/L 0.408691499522445 +DTXSID9046104 Css 3compartmentss Human 95% 405 mg/L 625.8 mg/L 0.647171620325983 +DTXSID9046106 Css 3compartmentss Human 95% 0.8594 mg/L 13.02 mg/L 0.0660061443932412 +DTXSID9046108 Css 3compartmentss Human 95% 0.5412 mg/L 1.822 mg/L 0.297036223929748 +DTXSID9046150 Css 3compartmentss Human 95% 1.112 mg/L 0.3909 mg/L 2.84471731900742 +DTXSID9046152 Css 3compartmentss Human 95% 4.53 mg/L 0.1984 mg/L 22.8326612903226 +DTXSID9046154 Css 3compartmentss Human 95% 0.9771 mg/L 4.432 mg/L 0.220464801444043 +DTXSID9046156 Css 3compartmentss Human 95% 50.01 mg/L 162.1 mg/L 0.308513263417643 +DTXSID9046158 Css 3compartmentss Human 95% 4.304 mg/L 480.5 mg/L 0.0089573361082206 +DTXSID9046231 Css 3compartmentss Human 95% 6.946 mg/L 11.13 mg/L 0.624079065588499 +DTXSID9046233 Css 3compartmentss Human 95% 7.749 mg/L 0.3709 mg/L 20.8924238339175 +DTXSID9046235 Css 3compartmentss Human 95% 24.91 mg/L 154.7 mg/L 0.161021331609567 +DTXSID9046237 Css 3compartmentss Human 95% 9.122 mg/L 5.958 mg/L 1.53105068815039 +DTXSID9046239 Css 3compartmentss Human 95% 1.105 mg/L 5.226 mg/L 0.211442786069652 +DTXSID9046281 Css 3compartmentss Human 95% 5.158 mg/L 46.05 mg/L 0.112008686210641 +DTXSID9046283 Css 3compartmentss Human 95% 3.219 mg/L 2.831 mg/L 1.13705404450724 +DTXSID9046285 Css 3compartmentss Human 95% 2.353 mg/L 0.4443 mg/L 5.29597119063696 +DTXSID9046287 Css 3compartmentss Human 95% 1.435 mg/L 0.9182 mg/L 1.56284033979525 +DTXSID9046289 Css 3compartmentss Human 95% 2.024 mg/L 1.215 mg/L 1.66584362139918 +DTXSID9046310 Css 3compartmentss Human 95% 4.423 mg/L 1.076 mg/L 4.11059479553903 +DTXSID9046360 Css 3compartmentss Human 95% 0.3597 mg/L 31.14 mg/L 0.0115510597302505 +DTXSID9046443 Css 3compartmentss Human 95% 8.418 mg/L 0.767 mg/L 10.9752281616688 +DTXSID9046445 Css 3compartmentss Human 95% 43.75 mg/L 66.77 mg/L 0.655234386700614 +DTXSID9046449 Css 3compartmentss Human 95% 2.16 mg/L 3.788 mg/L 0.570221752903907 +DTXSID9046491 Css 3compartmentss Human 95% 5.157 mg/L 5.801 mg/L 0.888984657817618 +DTXSID9046495 Css 3compartmentss Human 95% 7.225 mg/L 1.034 mg/L 6.98742746615087 +DTXSID9046497 Css 3compartmentss Human 95% 1.582 mg/L 29.89 mg/L 0.0529274004683841 +DTXSID9046499 Css 3compartmentss Human 95% 4.287 mg/L 0.5015 mg/L 8.54835493519442 +DTXSID9046520 Css 3compartmentss Human 95% 6.445 mg/L 4.908 mg/L 1.31316218418908 +DTXSID9046524 Css 3compartmentss Human 95% 1.012 mg/L 0.731 mg/L 1.3844049247606 +DTXSID9046526 Css 3compartmentss Human 95% 0.3758 mg/L 0.4425 mg/L 0.849265536723164 +DTXSID9046570 Css 3compartmentss Human 95% 1.543 mg/L 1.316 mg/L 1.17249240121581 +DTXSID9046572 Css 3compartmentss Human 95% 4.165 mg/L 4.947 mg/L 0.84192439862543 +DTXSID9046574 Css 3compartmentss Human 95% 5.487 mg/L 6.35 mg/L 0.864094488188976 +DTXSID9046576 Css 3compartmentss Human 95% 2.79 mg/L 15.23 mg/L 0.183191070256074 +DTXSID9046578 Css 3compartmentss Human 95% 7.616 mg/L 542.8 mg/L 0.0140309506263817 +DTXSID90465947 Css 3compartmentss Human 95% 5.992 mg/L NA NA NA +DTXSID9046601 Css 3compartmentss Human 95% 5.711 mg/L 6.513 mg/L 0.876861661292799 +DTXSID9046603 Css 3compartmentss Human 95% 4.988 mg/L 6.544 mg/L 0.762224938875306 +DTXSID9046607 Css 3compartmentss Human 95% 7.702 mg/L 3.344 mg/L 2.30322966507177 +DTXSID9046609 Css 3compartmentss Human 95% 6.521 mg/L 5.548 mg/L 1.1753785147801 +DTXSID9046651 Css 3compartmentss Human 95% 7.399 mg/L 4.403 mg/L 1.68044515103339 +DTXSID9046653 Css 3compartmentss Human 95% 3.31 mg/L 9.2 mg/L 0.359782608695652 +DTXSID9046657 Css 3compartmentss Human 95% 5.485 mg/L 5.282 mg/L 1.03843241196516 +DTXSID9046659 Css 3compartmentss Human 95% 21.47 mg/L 5.299 mg/L 4.05170786940932 +DTXSID9046730 Css 3compartmentss Human 95% 1.226 mg/L 9.922 mg/L 0.123563797621447 +DTXSID9046732 Css 3compartmentss Human 95% 5.682 mg/L 6.515 mg/L 0.872141212586339 +DTXSID9046734 Css 3compartmentss Human 95% 0.5423 mg/L 0.4415 mg/L 1.22831257078143 +DTXSID9046736 Css 3compartmentss Human 95% 6.491 mg/L 7.24 mg/L 0.896546961325967 +DTXSID9046738 Css 3compartmentss Human 95% 9.538 mg/L 155.9 mg/L 0.061180243745991 +DTXSID9046780 Css 3compartmentss Human 95% 11.91 mg/L 2.481 mg/L 4.80048367593712 +DTXSID9046782 Css 3compartmentss Human 95% 28.58 mg/L 16.09 mg/L 1.77625854568055 +DTXSID9046784 Css 3compartmentss Human 95% 4.371 mg/L 0.2375 mg/L 18.4042105263158 +DTXSID9046786 Css 3compartmentss Human 95% 0.9775 mg/L 4.456 mg/L 0.219367145421903 +DTXSID9046788 Css 3compartmentss Human 95% 5.626 mg/L 1.713 mg/L 3.28429655575015 +DTXSID9046813 Css 3compartmentss Human 95% 3.189 mg/L 2.498 mg/L 1.27662129703763 +DTXSID9046815 Css 3compartmentss Human 95% 4.982 mg/L 7.375 mg/L 0.675525423728814 +DTXSID9046817 Css 3compartmentss Human 95% 7.272 mg/L 14.69 mg/L 0.49503063308373 +DTXSID9046861 Css 3compartmentss Human 95% 0.9174 mg/L 2.726 mg/L 0.336537050623624 +DTXSID9046863 Css 3compartmentss Human 95% 2.554 mg/L 0.8488 mg/L 3.00895381715363 +DTXSID9046867 Css 3compartmentss Human 95% 16.05 mg/L 40.82 mg/L 0.393189612934836 +DTXSID9046869 Css 3compartmentss Human 95% 0.2641 mg/L 0.1616 mg/L 1.63428217821782 +DTXSID9046942 Css 3compartmentss Human 95% 0.5063 mg/L 8.492 mg/L 0.0596208195949128 +DTXSID9046944 Css 3compartmentss Human 95% 1.558 mg/L NA NA NA +DTXSID9046946 Css 3compartmentss Human 95% 1.408 mg/L 0.3926 mg/L 3.58634742740703 +DTXSID9046992 Css 3compartmentss Human 95% 5.592 mg/L 2.19 mg/L 2.55342465753425 +DTXSID9046994 Css 3compartmentss Human 95% 7.204 mg/L 0.2481 mg/L 29.0366787585651 +DTXSID9047041 Css 3compartmentss Human 95% 2.844 mg/L 1.602 mg/L 1.7752808988764 +DTXSID9047091 Css 3compartmentss Human 95% 2.418 mg/L NA NA NA +DTXSID9047095 Css 3compartmentss Human 95% 1.754 mg/L NA NA NA +DTXSID9047099 Css 3compartmentss Human 95% 1.247 mg/L 53.88 mg/L 0.0231440237564959 +DTXSID9047126 Css 3compartmentss Human 95% 0.7176 mg/L 0.1354 mg/L 5.29985228951256 +DTXSID9047174 Css 3compartmentss Human 95% 4.359 mg/L 12.09 mg/L 0.360545905707196 +DTXSID9047201 Css 3compartmentss Human 95% 0.6475 mg/L 0.1908 mg/L 3.39360587002096 +DTXSID9047203 Css 3compartmentss Human 95% 1.622 mg/L 0.4412 mg/L 3.67633726201269 +DTXSID9047205 Css 3compartmentss Human 95% 20.59 mg/L 6.293 mg/L 3.27188940092166 +DTXSID9047251 Css 3compartmentss Human 95% 52.02 mg/L 52.42 mg/L 0.992369324685235 +DTXSID9047253 Css 3compartmentss Human 95% 10.72 mg/L 127 mg/L 0.0844094488188976 +DTXSID9047255 Css 3compartmentss Human 95% 8.66 mg/L 11.8 mg/L 0.733898305084746 +DTXSID9047257 Css 3compartmentss Human 95% 29.54 mg/L 36.68 mg/L 0.805343511450382 +DTXSID9047259 Css 3compartmentss Human 95% 0.4902 mg/L 9.43 mg/L 0.051983032873807 +DTXSID9047330 Css 3compartmentss Human 95% 10.02 mg/L 12.6 mg/L 0.795238095238095 +DTXSID9047334 Css 3compartmentss Human 95% 9.046 mg/L 2.231 mg/L 4.05468399820708 +DTXSID9047338 Css 3compartmentss Human 95% 4.123 mg/L 8.138 mg/L 0.506635536986975 +DTXSID9047411 Css 3compartmentss Human 95% 27.68 mg/L 15.19 mg/L 1.82225148123766 +DTXSID9047413 Css 3compartmentss Human 95% 21.9 mg/L NA NA NA +DTXSID9047415 Css 3compartmentss Human 95% 2.238 mg/L 1.944 mg/L 1.15123456790123 +DTXSID9047417 Css 3compartmentss Human 95% 6.235 mg/L 5.406 mg/L 1.15334813170551 +DTXSID9047419 Css 3compartmentss Human 95% 14.74 mg/L NA NA NA +DTXSID9047461 Css 3compartmentss Human 95% 5.844 mg/L 1.176 mg/L 4.96938775510204 +DTXSID9047540 Css 3compartmentss Human 95% 11.43 mg/L 11.33 mg/L 1.00882612533098 +DTXSID9047542 Css 3compartmentss Human 95% 5.9 mg/L 7.075 mg/L 0.833922261484099 +DTXSID9047548 Css 3compartmentss Human 95% 309.6 mg/L NA NA NA +DTXSID9047590 Css 3compartmentss Human 95% 16.82 mg/L 8.68 mg/L 1.93778801843318 +DTXSID9047592 Css 3compartmentss Human 95% 40.01 mg/L 36.47 mg/L 1.097066081711 +DTXSID9047594 Css 3compartmentss Human 95% 1.751 mg/L 27.5 mg/L 0.0636727272727273 +DTXSID9047596 Css 3compartmentss Human 95% 3.888 mg/L NA NA NA +DTXSID9047598 Css 3compartmentss Human 95% 1.852 mg/L 117.7 mg/L 0.0157349192863212 +DTXSID9047623 Css 3compartmentss Human 95% 0.9678 mg/L 4.306 mg/L 0.224756154203437 +DTXSID9047673 Css 3compartmentss Human 95% 3.559 mg/L NA NA NA +DTXSID9047677 Css 3compartmentss Human 95% 5.574 mg/L 4.911 mg/L 1.13500305436775 +DTXSID9047702 Css 3compartmentss Human 95% 2.253 mg/L 1.686 mg/L 1.33629893238434 +DTXSID9047704 Css 3compartmentss Human 95% 3.69 mg/L 17.29 mg/L 0.213418160786582 +DTXSID9047833 Css 3compartmentss Human 95% 7.816 mg/L 6.94 mg/L 1.12622478386167 +DTXSID9047835 Css 3compartmentss Human 95% 0.6443 mg/L 1.745 mg/L 0.369226361031519 +DTXSID9047837 Css 3compartmentss Human 95% 2.877 mg/L 1.537 mg/L 1.87182823682498 +DTXSID9047839 Css 3compartmentss Human 95% 11.18 mg/L 5.925 mg/L 1.88691983122363 +DTXSID9047881 Css 3compartmentss Human 95% 6.878 mg/L 4.256 mg/L 1.61607142857143 +DTXSID9047883 Css 3compartmentss Human 95% 16.34 mg/L 7818 mg/L 0.00209004860578153 +DTXSID9047885 Css 3compartmentss Human 95% 13.09 mg/L 18.42 mg/L 0.710640608034745 +DTXSID9047887 Css 3compartmentss Human 95% 3.618 mg/L 0.831 mg/L 4.35379061371841 +DTXSID9047960 Css 3compartmentss Human 95% 9.494 mg/L 4.992 mg/L 1.90184294871795 +DTXSID9047962 Css 3compartmentss Human 95% 12.69 mg/L 3.623 mg/L 3.50262213635109 +DTXSID9048190 Css 3compartmentss Human 95% 18.68 mg/L 48.63 mg/L 0.384125025704298 +DTXSID9048194 Css 3compartmentss Human 95% 16.63 mg/L NA NA NA +DTXSID9048196 Css 3compartmentss Human 95% 10.14 mg/L NA NA NA +DTXSID9048271 Css 3compartmentss Human 95% 9.914 mg/L 11.12 mg/L 0.891546762589928 +DTXSID9048437 Css 3compartmentss Human 95% 0.08968 mg/L NA NA NA +DTXSID9048483 Css 3compartmentss Human 95% 3.791 mg/L NA NA NA +DTXSID9048510 Css 3compartmentss Human 95% 24.5 mg/L 24.04 mg/L 1.01913477537438 +DTXSID9048514 Css 3compartmentss Human 95% 19.49 mg/L 24.34 mg/L 0.800739523418242 +DTXSID9048516 Css 3compartmentss Human 95% 24.66 mg/L 30.93 mg/L 0.797284190106692 +DTXSID9048518 Css 3compartmentss Human 95% 9.926 mg/L 65.52 mg/L 0.151495726495727 +DTXSID9048641 Css 3compartmentss Human 95% 1.002 mg/L 1.432 mg/L 0.699720670391061 +DTXSID9048643 Css 3compartmentss Human 95% 25.79 mg/L 10.09 mg/L 2.55599603567889 +DTXSID9048645 Css 3compartmentss Human 95% 20.5 mg/L 37.62 mg/L 0.544922913343966 +DTXSID9048647 Css 3compartmentss Human 95% 0.1191 mg/L 0.2737 mg/L 0.435147972232371 +DTXSID9048649 Css 3compartmentss Human 95% 6.726 mg/L 0.9261 mg/L 7.26271460965338 +DTXSID9048691 Css 3compartmentss Human 95% 4.398 mg/L 0.0652 mg/L 67.4539877300614 +DTXSID9048693 Css 3compartmentss Human 95% 0.8393 mg/L 0.4293 mg/L 1.95504309340787 +DTXSID9048695 Css 3compartmentss Human 95% 17.41 mg/L 7.307 mg/L 2.38264677706309 +DTXSID9048699 Css 3compartmentss Human 95% 11.68 mg/L 2.815 mg/L 4.14920071047957 +DTXSID9048720 Css 3compartmentss Human 95% 10.64 mg/L 0.8537 mg/L 12.4633946351177 +DTXSID9048722 Css 3compartmentss Human 95% 3.429 mg/L 0.1999 mg/L 17.1535767883942 +DTXSID9048724 Css 3compartmentss Human 95% 16.9 mg/L 58.94 mg/L 0.286732270105192 +DTXSID9048726 Css 3compartmentss Human 95% 1.014 mg/L 0.03841 mg/L 26.399375162718 +DTXSID9048728 Css 3compartmentss Human 95% 4.668 mg/L 7.476 mg/L 0.624398073836276 +DTXSID9048772 Css 3compartmentss Human 95% 25.79 mg/L 1.928 mg/L 13.3765560165975 +DTXSID9048774 Css 3compartmentss Human 95% 2.36 mg/L 0.8577 mg/L 2.75154482919436 +DTXSID9048776 Css 3compartmentss Human 95% 1.513 mg/L 3.323 mg/L 0.455311465543184 +DTXSID9048778 Css 3compartmentss Human 95% 20.75 mg/L 76.49 mg/L 0.27127729114917 +DTXSID9048801 Css 3compartmentss Human 95% 14.63 mg/L 29.07 mg/L 0.503267973856209 +DTXSID9048803 Css 3compartmentss Human 95% 2.369 mg/L 1.609 mg/L 1.47234307022996 +DTXSID9048805 Css 3compartmentss Human 95% 2.472 mg/L 10.02 mg/L 0.246706586826347 +DTXSID9048807 Css 3compartmentss Human 95% 5.887 mg/L 101.5 mg/L 0.058 +DTXSID9048851 Css 3compartmentss Human 95% 1.005 mg/L 0.1635 mg/L 6.14678899082569 +DTXSID9048853 Css 3compartmentss Human 95% 1.263 mg/L 0.8129 mg/L 1.55369664165334 +DTXSID9048855 Css 3compartmentss Human 95% 5.436 mg/L 1.064 mg/L 5.10902255639098 +DTXSID9048857 Css 3compartmentss Human 95% 2.424 mg/L 3.903 mg/L 0.621060722521138 +DTXSID9048859 Css 3compartmentss Human 95% 0.9009 mg/L 5.391 mg/L 0.167111853088481 +DTXSID9048930 Css 3compartmentss Human 95% 5.591 mg/L 1.924 mg/L 2.90592515592516 +DTXSID9048932 Css 3compartmentss Human 95% 5.104 mg/L 4.375 mg/L 1.16662857142857 +DTXSID9048934 Css 3compartmentss Human 95% 1.353 mg/L 2.181 mg/L 0.620357634112792 +DTXSID9048936 Css 3compartmentss Human 95% 3.096 mg/L 2.198 mg/L 1.40855323020928 +DTXSID9048938 Css 3compartmentss Human 95% 2.294 mg/L 4.647 mg/L 0.493651818377448 +DTXSID9048980 Css 3compartmentss Human 95% 2.629 mg/L 39.14 mg/L 0.0671691364333163 +DTXSID9048982 Css 3compartmentss Human 95% 9.022 mg/L 0.328 mg/L 27.5060975609756 +DTXSID9048984 Css 3compartmentss Human 95% 2.148 mg/L 45.77 mg/L 0.0469303036923749 +DTXSID9049033 Css 3compartmentss Human 95% 12.09 mg/L 30.14 mg/L 0.401128069011281 +DTXSID9049035 Css 3compartmentss Human 95% 11.16 mg/L 27.53 mg/L 0.405375953505267 +DTXSID9049037 Css 3compartmentss Human 95% 2.51 mg/L 10.46 mg/L 0.239961759082218 +DTXSID9049039 Css 3compartmentss Human 95% 6.061 mg/L 1.053 mg/L 5.75593542260209 +DTXSID9049083 Css 3compartmentss Human 95% 0.5403 mg/L 1.364 mg/L 0.396114369501466 +DTXSID9049243 Css 3compartmentss Human 95% 21.6 mg/L 14.42 mg/L 1.49791955617198 +DTXSID9049245 Css 3compartmentss Human 95% 2.538 mg/L 2.559 mg/L 0.99179366940211 +DTXSID9049293 Css 3compartmentss Human 95% 3.663 mg/L 4.258 mg/L 0.860263034288398 +DTXSID9049295 Css 3compartmentss Human 95% 0.4021 mg/L 0.2425 mg/L 1.65814432989691 +DTXSID9049324 Css 3compartmentss Human 95% 0.5092 mg/L 4.228 mg/L 0.120435193945128 +DTXSID9049326 Css 3compartmentss Human 95% 5 mg/L 5.338 mg/L 0.936680404645935 +DTXSID9049374 Css 3compartmentss Human 95% 0.3343 mg/L 0.8187 mg/L 0.408330279711738 +DTXSID9049376 Css 3compartmentss Human 95% 7.283 mg/L 4.31 mg/L 1.68979118329466 +DTXSID9049401 Css 3compartmentss Human 95% 3.326 mg/L 31.11 mg/L 0.106910961105754 +DTXSID9049403 Css 3compartmentss Human 95% 1.747 mg/L NA NA NA +DTXSID9049405 Css 3compartmentss Human 95% 7.252 mg/L 1.785 mg/L 4.06274509803922 +DTXSID9049407 Css 3compartmentss Human 95% 1.279 mg/L 1.752 mg/L 0.730022831050228 +DTXSID9049409 Css 3compartmentss Human 95% 6.522 mg/L 7.647 mg/L 0.852883483719105 +DTXSID9051662 Css 3compartmentss Human 95% 6.159 mg/L 6.752 mg/L 0.912174170616114 +DTXSID9051824 Css 3compartmentss Human 95% 0.3951 mg/L 2.432 mg/L 0.162458881578947 +DTXSID9052052 Css 3compartmentss Human 95% 2.114 mg/L NA NA NA +DTXSID9052399 Css 3compartmentss Human 95% 19.05 mg/L NA NA NA +DTXSID9052476 Css 3compartmentss Human 95% 4.577 mg/L NA NA NA +DTXSID9052509 Css 3compartmentss Human 95% 0.5124 mg/L 2.175 mg/L 0.235586206896552 +DTXSID9052555 Css 3compartmentss Human 95% 8.842 mg/L NA NA NA +DTXSID9052682 Css 3compartmentss Human 95% 19 mg/L NA NA NA +DTXSID9057630 Css 3compartmentss Human 95% 5.453 mg/L 9.377 mg/L 0.581529273754932 +DTXSID9057632 Css 3compartmentss Human 95% 0.373 mg/L 5.458 mg/L 0.0683400513008428 +DTXSID9057634 Css 3compartmentss Human 95% 1.33 mg/L 11.53 mg/L 0.115351257588899 +DTXSID9057636 Css 3compartmentss Human 95% 1.179 mg/L 0.8759 mg/L 1.34604406895764 +DTXSID9057680 Css 3compartmentss Human 95% 1.924 mg/L 0.1379 mg/L 13.952139231327 +DTXSID9057682 Css 3compartmentss Human 95% 5.037 mg/L 5.718 mg/L 0.88090241343127 +DTXSID9057684 Css 3compartmentss Human 95% 0.4201 mg/L 6.177 mg/L 0.0680103610166748 +DTXSID9057686 Css 3compartmentss Human 95% 5.524 mg/L 6.339 mg/L 0.87143082505127 +DTXSID9057688 Css 3compartmentss Human 95% 11.67 mg/L NA NA NA +DTXSID9057711 Css 3compartmentss Human 95% 58.65 mg/L 59.22 mg/L 0.990374873353597 +DTXSID9057713 Css 3compartmentss Human 95% 1.253 mg/L 6.722 mg/L 0.18640285629277 +DTXSID9057715 Css 3compartmentss Human 95% 3.161 mg/L 4.378 mg/L 0.722019186843307 +DTXSID9057717 Css 3compartmentss Human 95% 5.27 mg/L 1.236 mg/L 4.26375404530744 +DTXSID9057719 Css 3compartmentss Human 95% 14.47 mg/L 36.58 mg/L 0.395571350464735 +DTXSID9057761 Css 3compartmentss Human 95% 0.3984 mg/L NA NA NA +DTXSID9057763 Css 3compartmentss Human 95% 0.8442 mg/L 0.06652 mg/L 12.6909200240529 +DTXSID9057765 Css 3compartmentss Human 95% 1.097 mg/L 4.57 mg/L 0.240043763676149 +DTXSID9057767 Css 3compartmentss Human 95% 12.2 mg/L 38.17 mg/L 0.31962274037202 +DTXSID9057769 Css 3compartmentss Human 95% 1.032 mg/L 1.256 mg/L 0.821656050955414 +DTXSID9057840 Css 3compartmentss Human 95% 22.84 mg/L 6.486 mg/L 3.52143077397472 +DTXSID9057842 Css 3compartmentss Human 95% 4.23 mg/L 114.6 mg/L 0.0369109947643979 +DTXSID9057844 Css 3compartmentss Human 95% 6.317 mg/L 0.1864 mg/L 33.8894849785408 +DTXSID9057846 Css 3compartmentss Human 95% 5.708 mg/L 58.38 mg/L 0.0977732100034258 +DTXSID9057848 Css 3compartmentss Human 95% 4.026 mg/L 1.046 mg/L 3.84894837476099 +DTXSID9057894 Css 3compartmentss Human 95% 0.6028 mg/L NA NA NA +DTXSID9057898 Css 3compartmentss Human 95% 1.197 mg/L 68.03 mg/L 0.0175951785976775 +DTXSID9058654 Css 3compartmentss Human 95% 22.39 mg/L 1.824 mg/L 12.2752192982456 +DTXSID9061675 Css 3compartmentss Human 95% 2.076 mg/L NA NA NA +DTXSID9062304 Css 3compartmentss Human 95% 3.319 mg/L NA NA NA +DTXSID9063900 Css 3compartmentss Human 95% 0.2562 mg/L NA NA NA +DTXSID90648692 Css 3compartmentss Human 95% 5.894 mg/L NA NA NA +DTXSID9065867 Css 3compartmentss Human 95% 0.6747 mg/L NA NA NA +DTXSID90659061 Css 3compartmentss Human 95% 13.45 mg/L NA NA NA +DTXSID90858931 Css 3compartmentss Human 95% 3.761 mg/L 0.2593 mg/L 14.5044350173544 +DTXSID90861127 Css 3compartmentss Human 95% 0.2876 mg/L NA NA NA +DTXSID90862795 Css 3compartmentss Human 95% 7.527 mg/L NA NA NA +DTXSID90869249 Css 3compartmentss Human 95% 13.21 mg/L NA NA NA +DTXSID90870012 Css 3compartmentss Human 95% 138.6 mg/L NA NA NA +DTXSID90872319 Css 3compartmentss Human 95% 1.011 mg/L NA NA NA +DTXSID90872935 Css 3compartmentss Human 95% 39.35 mg/L NA NA NA +DTXSID90873225 Css 3compartmentss Human 95% 1.111 mg/L NA NA NA +DTXSID90873361 Css 3compartmentss Human 95% 58.71 mg/L NA NA NA +DTXSID90873366 Css 3compartmentss Human 95% 2.056 mg/L 2.127 mg/L 0.966619652092149 +DTXSID90873381 Css 3compartmentss Human 95% 0.5968 mg/L NA NA NA +DTXSID90873467 Css 3compartmentss Human 95% 12.48 mg/L NA NA NA +DTXSID90875704 Css 3compartmentss Human 95% 0.3483 mg/L NA NA NA +DTXSID90879808 Css 3compartmentss Human 95% 6.207 mg/L NA NA NA +DTXSID90880671 Css 3compartmentss Human 95% 0.1945 mg/L NA NA NA +DTXSID90880712 Css 3compartmentss Human 95% 9.567 mg/L NA NA NA +DTXSID90880737 Css 3compartmentss Human 95% 0.4578 mg/L NA NA NA +DTXSID90880818 Css 3compartmentss Human 95% 16.67 mg/L NA NA NA +DTXSID90880919 Css 3compartmentss Human 95% 6.263 mg/L NA NA NA +DTXSID90881229 Css 3compartmentss Human 95% 7.3 mg/L NA NA NA +DTXSID90881244 Css 3compartmentss Human 95% 1.353 mg/L NA NA NA +DTXSID90881249 Css 3compartmentss Human 95% 5.755 mg/L NA NA NA +DTXSID90978825 Css 3compartmentss Human 95% 27.37 mg/L NA NA NA +DTXSID90993235 Css 3compartmentss Human 95% 57.87 mg/L NA NA NA diff --git a/scripts/Dashboard-HTTK-CssunitsmgpL.txt b/scripts/Dashboard-HTTK-CssunitsmgpL.txt index 1e63b694..601adad1 100644 --- a/scripts/Dashboard-HTTK-CssunitsmgpL.txt +++ b/scripts/Dashboard-HTTK-CssunitsmgpL.txt @@ -1,135837 +1,148052 @@ DTXSID Parameter Measured Predicted Units Model Reference Percentile Species Data.Source.Species -DTXSID0020020 Clint NA 2.334 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020020 Fup NA 0.1958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020020 Vd NA 0.3455 L/kg 1compartment NA NA Human Human +DTXSID001009966 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID001009966 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID001009966 Vd NA 0.4129 L/kg 1compartment NA NA Human Human +DTXSID001009966 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID001009966 TK.Half.Life NA 4.575 hours 1compartment NA NA Human Human +DTXSID001009966 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human +DTXSID001009966 Css NA 8.735 mg/L 3compartmentss NA 95% Human Human +DTXSID001009966 Css NA 0.9796 mg/L PBTK NA 50% Human Human +DTXSID001009966 Css NA 5.321 mg/L PBTK NA 95% Human Human +DTXSID001009966 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID001009966 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID001009966 Vd NA 0.4968 L/kg 1compartment NA NA Rat Human +DTXSID001009966 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID001009966 TK.Half.Life NA 1.404 hours 1compartment NA NA Rat Human +DTXSID001009966 Css NA 0.0644 mg/L 3compartmentss NA 50% Rat Human +DTXSID001009966 Css NA 0.3679 mg/L 3compartmentss NA 95% Rat Human +DTXSID001009966 Css NA 0.04757 mg/L PBTK NA 50% Rat Human +DTXSID001009966 Css NA 0.2199 mg/L PBTK NA 95% Rat Human +DTXSID001014436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID001014436 Fup 0.8723 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID001014436 Vd NA 1.228 L/kg 1compartment NA NA Human Human +DTXSID001014436 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID001014436 TK.Half.Life NA 9.409 hours 1compartment NA NA Human Human +DTXSID001014436 Css NA 0.4118 mg/L 3compartmentss NA 50% Human Human +DTXSID001014436 Css NA 2.928 mg/L 3compartmentss NA 95% Human Human +DTXSID001014436 Css NA 0.4308 mg/L PBTK NA 50% Human Human +DTXSID001014436 Css NA 2.107 mg/L PBTK NA 95% Human Human +DTXSID001014436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID001014436 Fup 0.8723 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID001014436 Vd NA 1.189 L/kg 1compartment NA NA Rat Human +DTXSID001014436 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID001014436 TK.Half.Life NA 3.029 hours 1compartment NA NA Rat Human +DTXSID001014436 Css NA 0.002077 mg/L 3compartmentss NA 50% Rat Human +DTXSID001014436 Css NA 0.01465 mg/L 3compartmentss NA 95% Rat Human +DTXSID001014436 Css NA 0.002148 mg/L PBTK NA 50% Rat Human +DTXSID001014436 Css NA 0.01032 mg/L PBTK NA 95% Rat Human +DTXSID00143784 Clint 222 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID00143784 Fup 0.021 NA NA Williamson 2020 NA Human Human +DTXSID00143784 Vd NA 2.428 L/kg 1compartment NA NA Human Human +DTXSID00143784 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00143784 TK.Half.Life NA 4.658 hours 1compartment NA NA Human Human +DTXSID00143784 Css NA 0.1338 mg/L 3compartmentss NA 50% Human Human +DTXSID00143784 Css NA 1.147 mg/L 3compartmentss NA 95% Human Human +DTXSID00143784 Css NA 0.0891 mg/L PBTK NA 50% Human Human +DTXSID00143784 Css NA 0.7143 mg/L PBTK NA 95% Human Human +DTXSID00143784 Clint 222 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID00143784 Fup 0.021 NA NA Williamson 2020 NA Rat Human +DTXSID00143784 Vd NA 1.81 L/kg 1compartment NA NA Rat Human +DTXSID00143784 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00143784 TK.Half.Life NA 1.339 hours 1compartment NA NA Rat Human +DTXSID00143784 Css NA 0.005213 mg/L 3compartmentss NA 50% Rat Human +DTXSID00143784 Css NA 0.04766 mg/L 3compartmentss NA 95% Rat Human +DTXSID00143784 Css NA 0.003316 mg/L PBTK NA 50% Rat Human +DTXSID00143784 Css NA 0.02863 mg/L PBTK NA 95% Rat Human +DTXSID00144539 Clint 2.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00144539 Fup 0.026 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00144539 Vd NA 1.9 L/kg 1compartment NA NA Human Human +DTXSID00144539 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID00144539 TK.Half.Life NA 102.3 hours 1compartment NA NA Human Human +DTXSID00144539 Css NA 8.392 mg/L 3compartmentss NA 50% Human Human +DTXSID00144539 Css NA 52.94 mg/L 3compartmentss NA 95% Human Human +DTXSID00144539 Css NA 5.416 mg/L PBTK NA 50% Human Human +DTXSID00144539 Css NA 32.23 mg/L PBTK NA 95% Human Human +DTXSID00144539 Clint 2.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00144539 Fup 0.026 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00144539 Vd NA 1.424 L/kg 1compartment NA NA Rat Human +DTXSID00144539 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID00144539 TK.Half.Life NA 31.81 hours 1compartment NA NA Rat Human +DTXSID00144539 Css NA 0.9792 mg/L 3compartmentss NA 50% Rat Human +DTXSID00144539 Css NA 4.882 mg/L 3compartmentss NA 95% Rat Human +DTXSID00144539 Css NA 0.6173 mg/L PBTK NA 50% Rat Human +DTXSID00144539 Css NA 2.859 mg/L PBTK NA 95% Rat Human +DTXSID00155842 Clint 1.385 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00155842 Fup 0.0581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00155842 Vd NA 2.787 L/kg 1compartment NA NA Human Human +DTXSID00155842 Days.Css NA 63 Days PBTK NA NA Human Human +DTXSID00155842 TK.Half.Life NA 289.7 hours 1compartment NA NA Human Human +DTXSID00155842 Css NA 13.47 mg/L 3compartmentss NA 50% Human Human +DTXSID00155842 Css NA 56.55 mg/L 3compartmentss NA 95% Human Human +DTXSID00155842 Css NA 9.232 mg/L PBTK NA 50% Human Human +DTXSID00155842 Css NA 36.59 mg/L PBTK NA 95% Human Human +DTXSID00155842 Clint 1.385 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00155842 Fup 0.0581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00155842 Vd NA 2.092 L/kg 1compartment NA NA Rat Human +DTXSID00155842 Days.Css NA 28 Days PBTK NA NA Rat Human +DTXSID00155842 TK.Half.Life NA 48.71 hours 1compartment NA NA Rat Human +DTXSID00155842 Css NA 1.493 mg/L 3compartmentss NA 50% Rat Human +DTXSID00155842 Css NA 4.461 mg/L 3compartmentss NA 95% Rat Human +DTXSID00155842 Css NA 1.009 mg/L PBTK NA 50% Rat Human +DTXSID00155842 Css NA 2.814 mg/L PBTK NA 95% Rat Human +DTXSID00157169 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00157169 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00157169 Vd NA 0.445 L/kg 1compartment NA NA Human Human +DTXSID00157169 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00157169 TK.Half.Life NA 9.112 hours 1compartment NA NA Human Human +DTXSID00157169 Css NA 2.304 mg/L 3compartmentss NA 50% Human Human +DTXSID00157169 Css NA 9.44 mg/L 3compartmentss NA 95% Human Human +DTXSID00157169 Css NA 1.642 mg/L PBTK NA 50% Human Human +DTXSID00157169 Css NA 5.928 mg/L PBTK NA 95% Human Human +DTXSID00157169 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00157169 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00157169 Vd NA 0.4443 L/kg 1compartment NA NA Rat Human +DTXSID00157169 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00157169 TK.Half.Life NA 3.1 hours 1compartment NA NA Rat Human +DTXSID00157169 Css NA 0.1496 mg/L 3compartmentss NA 50% Rat Human +DTXSID00157169 Css NA 0.5104 mg/L 3compartmentss NA 95% Rat Human +DTXSID00157169 Css NA 0.1046 mg/L PBTK NA 50% Rat Human +DTXSID00157169 Css NA 0.3096 mg/L PBTK NA 95% Rat Human +DTXSID00157826 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00157826 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00157826 Vd NA 1.094 L/kg 1compartment NA NA Human Human +DTXSID00157826 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00157826 TK.Half.Life NA 2.774 hours 1compartment NA NA Human Human +DTXSID00157826 Css NA 0.2134 mg/L 3compartmentss NA 50% Human Human +DTXSID00157826 Css NA 1.356 mg/L 3compartmentss NA 95% Human Human +DTXSID00157826 Css NA 0.1613 mg/L PBTK NA 50% Human Human +DTXSID00157826 Css NA 0.9236 mg/L PBTK NA 95% Human Human +DTXSID00157826 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00157826 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00157826 Vd NA 1.016 L/kg 1compartment NA NA Rat Human +DTXSID00157826 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00157826 TK.Half.Life NA 1.446 hours 1compartment NA NA Rat Human +DTXSID00157826 Css NA 0.0252 mg/L 3compartmentss NA 50% Rat Human +DTXSID00157826 Css NA 0.1166 mg/L 3compartmentss NA 95% Rat Human +DTXSID00157826 Css NA 0.01916 mg/L PBTK NA 50% Rat Human +DTXSID00157826 Css NA 0.07727 mg/L PBTK NA 95% Rat Human +DTXSID00162475 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00162475 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00162475 Vd NA 0.7004 L/kg 1compartment NA NA Human Human +DTXSID00162475 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00162475 TK.Half.Life NA 3.032 hours 1compartment NA NA Human Human +DTXSID00162475 Css NA 0.5044 mg/L 3compartmentss NA 50% Human Human +DTXSID00162475 Css NA 3.296 mg/L 3compartmentss NA 95% Human Human +DTXSID00162475 Css NA 0.3352 mg/L PBTK NA 50% Human Human +DTXSID00162475 Css NA 2.063 mg/L PBTK NA 95% Human Human +DTXSID00162475 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00162475 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00162475 Vd NA 0.5994 L/kg 1compartment NA NA Rat Human +DTXSID00162475 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00162475 TK.Half.Life NA 1.509 hours 1compartment NA NA Rat Human +DTXSID00162475 Css NA 0.06185 mg/L 3compartmentss NA 50% Rat Human +DTXSID00162475 Css NA 0.2932 mg/L 3compartmentss NA 95% Rat Human +DTXSID00162475 Css NA 0.04025 mg/L PBTK NA 50% Rat Human +DTXSID00162475 Css NA 0.1765 mg/L PBTK NA 95% Rat Human +DTXSID00167364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00167364 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00167364 Vd NA 1.923 L/kg 1compartment NA NA Human Human +DTXSID00167364 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00167364 TK.Half.Life NA 4.289 hours 1compartment NA NA Human Human +DTXSID00167364 Css NA 0.2033 mg/L 3compartmentss NA 50% Human Human +DTXSID00167364 Css NA 1.724 mg/L 3compartmentss NA 95% Human Human +DTXSID00167364 Css NA 0.1523 mg/L PBTK NA 50% Human Human +DTXSID00167364 Css NA 1.157 mg/L PBTK NA 95% Human Human +DTXSID00167364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00167364 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00167364 Vd NA 0.1703 L/kg 1compartment NA NA Rat Human +DTXSID00167364 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID00167364 TK.Half.Life NA 56.77 hours 1compartment NA NA Rat Human +DTXSID00167364 Css NA 12.11 mg/L 3compartmentss NA 50% Rat Human +DTXSID00167364 Css NA 51.49 mg/L 3compartmentss NA 95% Rat Human +DTXSID00167364 Css NA 6.78 mg/L PBTK NA 50% Rat Human +DTXSID00167364 Css NA 28.84 mg/L PBTK NA 95% Rat Human +DTXSID00172913 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00172913 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00172913 Vd NA 1.971 L/kg 1compartment NA NA Human Human +DTXSID00172913 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00172913 TK.Half.Life NA 2.548 hours 1compartment NA NA Human Human +DTXSID00172913 Css NA 0.0686 mg/L 3compartmentss NA 50% Human Human +DTXSID00172913 Css NA 0.4956 mg/L 3compartmentss NA 95% Human Human +DTXSID00172913 Css NA 0.05482 mg/L PBTK NA 50% Human Human +DTXSID00172913 Css NA 0.3569 mg/L PBTK NA 95% Human Human +DTXSID00172913 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00172913 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00172913 Vd NA 1.572 L/kg 1compartment NA NA Rat Human +DTXSID00172913 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00172913 TK.Half.Life NA 0.9118 hours 1compartment NA NA Rat Human +DTXSID00172913 Css NA 0.008449 mg/L 3compartmentss NA 50% Rat Human +DTXSID00172913 Css NA 0.04904 mg/L 3compartmentss NA 95% Rat Human +DTXSID00172913 Css NA 0.006786 mg/L PBTK NA 50% Rat Human +DTXSID00172913 Css NA 0.03467 mg/L PBTK NA 95% Rat Human +DTXSID00178672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00178672 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00178672 Vd NA 1.858 L/kg 1compartment NA NA Human Human +DTXSID00178672 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00178672 TK.Half.Life NA 2.419 hours 1compartment NA NA Human Human +DTXSID00178672 Css NA 0.069 mg/L 3compartmentss NA 50% Human Human +DTXSID00178672 Css NA 0.4952 mg/L 3compartmentss NA 95% Human Human +DTXSID00178672 Css NA 0.05416 mg/L PBTK NA 50% Human Human +DTXSID00178672 Css NA 0.362 mg/L PBTK NA 95% Human Human +DTXSID00178672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00178672 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00178672 Vd NA 1.486 L/kg 1compartment NA NA Rat Human +DTXSID00178672 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00178672 TK.Half.Life NA 0.888 hours 1compartment NA NA Rat Human +DTXSID00178672 Css NA 0.008543 mg/L 3compartmentss NA 50% Rat Human +DTXSID00178672 Css NA 0.04853 mg/L 3compartmentss NA 95% Rat Human +DTXSID00178672 Css NA 0.006764 mg/L PBTK NA 50% Rat Human +DTXSID00178672 Css NA 0.03489 mg/L PBTK NA 95% Rat Human +DTXSID00184293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00184293 Fup 0.061 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00184293 Vd NA 2.591 L/kg 1compartment NA NA Human Human +DTXSID00184293 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00184293 TK.Half.Life NA 8.984 hours 1compartment NA NA Human Human +DTXSID00184293 Css NA 0.3852 mg/L 3compartmentss NA 50% Human Human +DTXSID00184293 Css NA 2.744 mg/L 3compartmentss NA 95% Human Human +DTXSID00184293 Css NA 0.2818 mg/L PBTK NA 50% Human Human +DTXSID00184293 Css NA 1.885 mg/L PBTK NA 95% Human Human +DTXSID00184293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00184293 Fup 0.061 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00184293 Vd NA 2.156 L/kg 1compartment NA NA Rat Human +DTXSID00184293 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00184293 TK.Half.Life NA 3.304 hours 1compartment NA NA Rat Human +DTXSID00184293 Css NA 0.04916 mg/L 3compartmentss NA 50% Rat Human +DTXSID00184293 Css NA 0.3012 mg/L 3compartmentss NA 95% Rat Human +DTXSID00184293 Css NA 0.03578 mg/L PBTK NA 50% Rat Human +DTXSID00184293 Css NA 0.2029 mg/L PBTK NA 95% Rat Human +DTXSID00190197 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00190197 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00190197 Vd NA 3.048 L/kg 1compartment NA NA Human Human +DTXSID00190197 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID00190197 TK.Half.Life NA 73.87 hours 1compartment NA NA Human Human +DTXSID00190197 Css NA 2.953 mg/L 3compartmentss NA 50% Human Human +DTXSID00190197 Css NA 19.43 mg/L 3compartmentss NA 95% Human Human +DTXSID00190197 Css NA 2.04 mg/L PBTK NA 50% Human Human +DTXSID00190197 Css NA 13.02 mg/L PBTK NA 95% Human Human +DTXSID00190197 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00190197 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00190197 Vd NA 2.283 L/kg 1compartment NA NA Rat Human +DTXSID00190197 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID00190197 TK.Half.Life NA 11 hours 1compartment NA NA Rat Human +DTXSID00190197 Css NA 0.382 mg/L 3compartmentss NA 50% Rat Human +DTXSID00190197 Css NA 2.218 mg/L 3compartmentss NA 95% Rat Human +DTXSID00190197 Css NA 0.2605 mg/L PBTK NA 50% Rat Human +DTXSID00190197 Css NA 1.479 mg/L PBTK NA 95% Rat Human +DTXSID00190617 Clint 10.96 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00190617 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00190617 Vd NA 1.613 L/kg 1compartment NA NA Human Human +DTXSID00190617 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00190617 TK.Half.Life NA 5.324 hours 1compartment NA NA Human Human +DTXSID00190617 Css NA 0.3298 mg/L 3compartmentss NA 50% Human Human +DTXSID00190617 Css NA 2.118 mg/L 3compartmentss NA 95% Human Human +DTXSID00190617 Css NA 0.2306 mg/L PBTK NA 50% Human Human +DTXSID00190617 Css NA 1.386 mg/L PBTK NA 95% Human Human +DTXSID00190617 Clint 10.96 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00190617 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00190617 Vd NA 1.253 L/kg 1compartment NA NA Rat Human +DTXSID00190617 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00190617 TK.Half.Life NA 2.033 hours 1compartment NA NA Rat Human +DTXSID00190617 Css NA 0.04164 mg/L 3compartmentss NA 50% Rat Human +DTXSID00190617 Css NA 0.2006 mg/L 3compartmentss NA 95% Rat Human +DTXSID00190617 Css NA 0.0287 mg/L PBTK NA 50% Rat Human +DTXSID00190617 Css NA 0.1287 mg/L PBTK NA 95% Rat Human +DTXSID00196977 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00196977 Fup 0.531 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00196977 Vd NA 2.377 L/kg 1compartment NA NA Human Human +DTXSID00196977 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00196977 TK.Half.Life NA 3.526 hours 1compartment NA NA Human Human +DTXSID00196977 Css NA 0.09369 mg/L 3compartmentss NA 50% Human Human +DTXSID00196977 Css NA 0.8649 mg/L 3compartmentss NA 95% Human Human +DTXSID00196977 Css NA 0.09662 mg/L PBTK NA 50% Human Human +DTXSID00196977 Css NA 0.6473 mg/L PBTK NA 95% Human Human +DTXSID00196977 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00196977 Fup 0.531 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00196977 Vd NA 2.407 L/kg 1compartment NA NA Rat Human +DTXSID00196977 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00196977 TK.Half.Life NA 2.006 hours 1compartment NA NA Rat Human +DTXSID00196977 Css NA 0.01052 mg/L 3compartmentss NA 50% Rat Human +DTXSID00196977 Css NA 0.08178 mg/L 3compartmentss NA 95% Rat Human +DTXSID00196977 Css NA 0.01113 mg/L PBTK NA 50% Rat Human +DTXSID00196977 Css NA 0.05871 mg/L PBTK NA 95% Rat Human +DTXSID0020020 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020020 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020020 Vd NA 0.4623 L/kg 1compartment NA NA Human Human DTXSID0020020 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020020 TK.Half.Life NA 2.535 hours 1compartment NA NA Human Human -DTXSID0020020 Css NA 0.8851 mg/L 3compartmentss NA 50% Human Human -DTXSID0020020 Css NA 4.348 mg/L 3compartmentss NA 95% Human Human -DTXSID0020020 Css NA 0.5674 mg/L PBTK NA 50% Human Human -DTXSID0020020 Css NA 2.637 mg/L PBTK NA 95% Human Human -DTXSID0020020 Clint NA 2.334 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020020 Fup NA 0.1958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020020 Vd NA 0.3355 L/kg 1compartment NA NA Rat Human +DTXSID0020020 TK.Half.Life NA 0.5654 hours 1compartment NA NA Human Human +DTXSID0020020 Css NA 0.05767 mg/L 3compartmentss NA 50% Human Human +DTXSID0020020 Css NA 0.442 mg/L 3compartmentss NA 95% Human Human +DTXSID0020020 Css NA 0.04006 mg/L PBTK NA 50% Human Human +DTXSID0020020 Css NA 0.2855 mg/L PBTK NA 95% Human Human +DTXSID0020020 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020020 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020020 Vd NA 0.4503 L/kg 1compartment NA NA Rat Human DTXSID0020020 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020020 TK.Half.Life NA 1.366 hours 1compartment NA NA Rat Human -DTXSID0020020 Css NA 0.414 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020020 Css NA 1.458 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020020 Css NA 0.252 mg/L PBTK NA 50% Rat Human -DTXSID0020020 Css NA 0.832 mg/L PBTK NA 95% Rat Human +DTXSID0020020 TK.Half.Life NA 0.2848 hours 1compartment NA NA Rat Human +DTXSID0020020 Css NA 0.007238 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020020 Css NA 0.04093 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020020 Css NA 0.00501 mg/L PBTK NA 50% Rat Human +DTXSID0020020 Css NA 0.02621 mg/L PBTK NA 95% Rat Human DTXSID0020022 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0020022 Fup 0.0111 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0020022 Vd NA 0.2344 L/kg 1compartment NA NA Human Human DTXSID0020022 Days.Css NA 31 Days PBTK NA NA Human Human DTXSID0020022 TK.Half.Life NA 136.6 hours 1compartment NA NA Human Human -DTXSID0020022 Css NA 57.34 mg/L 3compartmentss NA 50% Human Human -DTXSID0020022 Css NA 185.6 mg/L 3compartmentss NA 95% Human Human -DTXSID0020022 Css NA 38.97 mg/L PBTK NA 50% Human Human -DTXSID0020022 Css NA 117 mg/L PBTK NA 95% Human Human +DTXSID0020022 Css NA 52.06 mg/L 3compartmentss NA 50% Human Human +DTXSID0020022 Css NA 161.4 mg/L 3compartmentss NA 95% Human Human +DTXSID0020022 Css NA 33.5 mg/L PBTK NA 50% Human Human +DTXSID0020022 Css NA 103.9 mg/L PBTK NA 95% Human Human DTXSID0020022 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0020022 Fup 0.004729 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0020022 Vd NA 0.1889 L/kg 1compartment NA NA Rat Rat DTXSID0020022 Days.Css NA 19 Days PBTK NA NA Rat Rat DTXSID0020022 TK.Half.Life NA 88.05 hours 1compartment NA NA Rat Rat -DTXSID0020022 Css NA 60.56 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0020022 Css NA 339 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0020022 Css NA 36.74 mg/L PBTK NA 50% Rat Rat -DTXSID0020022 Css NA 187.5 mg/L PBTK NA 95% Rat Rat +DTXSID0020022 Css NA 4.002 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0020022 Css NA 30.3 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0020022 Css NA 2.615 mg/L PBTK NA 50% Rat Rat +DTXSID0020022 Css NA 19.92 mg/L PBTK NA 95% Rat Rat +DTXSID00200503 Clint 61.66 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00200503 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00200503 Vd NA 0.9186 L/kg 1compartment NA NA Human Human +DTXSID00200503 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00200503 TK.Half.Life NA 0.9819 hours 1compartment NA NA Human Human +DTXSID00200503 Css NA 0.03442 mg/L 3compartmentss NA 50% Human Human +DTXSID00200503 Css NA 0.2581 mg/L 3compartmentss NA 95% Human Human +DTXSID00200503 Css NA 0.02416 mg/L PBTK NA 50% Human Human +DTXSID00200503 Css NA 0.1747 mg/L PBTK NA 95% Human Human +DTXSID00200503 Clint 61.66 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00200503 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00200503 Vd NA 0.7763 L/kg 1compartment NA NA Rat Human +DTXSID00200503 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00200503 TK.Half.Life NA 0.4068 hours 1compartment NA NA Rat Human +DTXSID00200503 Css NA 0.004415 mg/L 3compartmentss NA 50% Rat Human +DTXSID00200503 Css NA 0.02695 mg/L 3compartmentss NA 95% Rat Human +DTXSID00200503 Css NA 0.003084 mg/L PBTK NA 50% Rat Human +DTXSID00200503 Css NA 0.0179 mg/L PBTK NA 95% Rat Human DTXSID0020070 Clint NA 1.438 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020070 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0020070 Vd NA 0.6509 L/kg 1compartment NA NA Human Human DTXSID0020070 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0020070 TK.Half.Life NA 1.489 hours 1compartment NA NA Human Human -DTXSID0020070 Css NA 0.2746 mg/L 3compartmentss NA 50% Human Human -DTXSID0020070 Css NA 1.688 mg/L 3compartmentss NA 95% Human Human -DTXSID0020070 Css NA 0.218 mg/L PBTK NA 50% Human Human -DTXSID0020070 Css NA 1.107 mg/L PBTK NA 95% Human Human +DTXSID0020070 Css NA 0.2283 mg/L 3compartmentss NA 50% Human Human +DTXSID0020070 Css NA 1.506 mg/L 3compartmentss NA 95% Human Human +DTXSID0020070 Css NA 0.182 mg/L PBTK NA 50% Human Human +DTXSID0020070 Css NA 0.981 mg/L PBTK NA 95% Human Human DTXSID0020070 Clint NA 1.438 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020070 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0020070 Vd NA 0.7012 L/kg 1compartment NA NA Rat Human DTXSID0020070 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0020070 TK.Half.Life NA 0.8063 hours 1compartment NA NA Rat Human -DTXSID0020070 Css NA 0.1093 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020070 Css NA 0.6009 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020070 Css NA 0.0855 mg/L PBTK NA 50% Rat Human -DTXSID0020070 Css NA 0.3651 mg/L PBTK NA 95% Rat Human -DTXSID0020072 Clint NA 10.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020072 Fup NA 0.0934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020072 Vd NA 1.651 L/kg 1compartment NA NA Human Human +DTXSID0020070 Css NA 0.006596 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020070 Css NA 0.0524 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020070 Css NA 0.005114 mg/L PBTK NA 50% Rat Human +DTXSID0020070 Css NA 0.03376 mg/L PBTK NA 95% Rat Human +DTXSID0020072 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020072 Fup 0.0882 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020072 Vd NA 1.611 L/kg 1compartment NA NA Human Human DTXSID0020072 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020072 TK.Half.Life NA 8.933 hours 1compartment NA NA Human Human -DTXSID0020072 Css NA 0.7158 mg/L 3compartmentss NA 50% Human Human -DTXSID0020072 Css NA 4.993 mg/L 3compartmentss NA 95% Human Human -DTXSID0020072 Css NA 0.4742 mg/L PBTK NA 50% Human Human -DTXSID0020072 Css NA 3.133 mg/L PBTK NA 95% Human Human -DTXSID0020072 Clint NA 10.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020072 Fup NA 0.0934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020072 Vd NA 1.256 L/kg 1compartment NA NA Rat Human +DTXSID0020072 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human +DTXSID0020072 Css NA 0.3591 mg/L 3compartmentss NA 50% Human Human +DTXSID0020072 Css NA 2.641 mg/L 3compartmentss NA 95% Human Human +DTXSID0020072 Css NA 0.2373 mg/L PBTK NA 50% Human Human +DTXSID0020072 Css NA 1.66 mg/L PBTK NA 95% Human Human +DTXSID0020072 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020072 Fup 0.0882 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020072 Vd NA 1.225 L/kg 1compartment NA NA Rat Human DTXSID0020072 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020072 TK.Half.Life NA 3.309 hours 1compartment NA NA Rat Human -DTXSID0020072 Css NA 0.3887 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020072 Css NA 1.945 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020072 Css NA 0.2438 mg/L PBTK NA 50% Rat Human -DTXSID0020072 Css NA 1.161 mg/L PBTK NA 95% Rat Human -DTXSID0020074 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0020072 TK.Half.Life NA 1.931 hours 1compartment NA NA Rat Human +DTXSID0020072 Css NA 0.04651 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020072 Css NA 0.2713 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020072 Css NA 0.0301 mg/L PBTK NA 50% Rat Human +DTXSID0020072 Css NA 0.1689 mg/L PBTK NA 95% Rat Human +DTXSID0020074 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0020074 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0020074 Vd NA 0.7647 L/kg 1compartment NA NA Human Human DTXSID0020074 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0020074 TK.Half.Life NA 5.1 hours 1compartment NA NA Human Human -DTXSID0020074 Css NA 0.4702 mg/L 3compartmentss NA 50% Human Human -DTXSID0020074 Css NA 3.01 mg/L 3compartmentss NA 95% Human Human -DTXSID0020074 Css NA 0.453 mg/L PBTK NA 50% Human Human -DTXSID0020074 Css NA 2.106 mg/L PBTK NA 95% Human Human -DTXSID0020074 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0020074 Css NA 0.5558 mg/L 3compartmentss NA 50% Human Human +DTXSID0020074 Css NA 2.475 mg/L 3compartmentss NA 95% Human Human +DTXSID0020074 Css NA 0.6114 mg/L PBTK NA 50% Human Human +DTXSID0020074 Css NA 2.723 mg/L PBTK NA 95% Human Human +DTXSID0020074 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0020074 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0020074 Vd NA 0.8017 L/kg 1compartment NA NA Rat Human DTXSID0020074 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0020074 TK.Half.Life NA 1.823 hours 1compartment NA NA Rat Human -DTXSID0020074 Css NA 0.1886 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020074 Css NA 1.134 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020074 Css NA 0.1818 mg/L PBTK NA 50% Rat Human -DTXSID0020074 Css NA 0.7319 mg/L PBTK NA 95% Rat Human +DTXSID0020074 Css NA 0.009144 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020074 Css NA 0.0566 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020074 Css NA 0.01015 mg/L PBTK NA 50% Rat Human +DTXSID0020074 Css NA 0.06396 mg/L PBTK NA 95% Rat Human DTXSID0020076 Clint NA 1.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020076 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020076 Vd NA 0.7982 L/kg 1compartment NA NA Human Human +DTXSID0020076 Vd NA 0.7983 L/kg 1compartment NA NA Human Human DTXSID0020076 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020076 TK.Half.Life NA 1.965 hours 1compartment NA NA Human Human -DTXSID0020076 Css NA 0.2901 mg/L 3compartmentss NA 50% Human Human -DTXSID0020076 Css NA 2.033 mg/L 3compartmentss NA 95% Human Human -DTXSID0020076 Css NA 0.243 mg/L PBTK NA 50% Human Human -DTXSID0020076 Css NA 1.356 mg/L PBTK NA 95% Human Human +DTXSID0020076 TK.Half.Life NA 1.966 hours 1compartment NA NA Human Human +DTXSID0020076 Css NA 0.2391 mg/L 3compartmentss NA 50% Human Human +DTXSID0020076 Css NA 1.629 mg/L 3compartmentss NA 95% Human Human +DTXSID0020076 Css NA 0.2008 mg/L PBTK NA 50% Human Human +DTXSID0020076 Css NA 1.104 mg/L PBTK NA 95% Human Human DTXSID0020076 Clint NA 1.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020076 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020076 Vd NA 0.8334 L/kg 1compartment NA NA Rat Human +DTXSID0020076 Vd NA 0.8335 L/kg 1compartment NA NA Rat Human DTXSID0020076 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020076 TK.Half.Life NA 0.9996 hours 1compartment NA NA Rat Human -DTXSID0020076 Css NA 0.1092 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020076 Css NA 0.7137 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020076 Css NA 0.09114 mg/L PBTK NA 50% Rat Human -DTXSID0020076 Css NA 0.4332 mg/L PBTK NA 95% Rat Human -DTXSID0020101 Clint NA 0.2799 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020101 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020101 Vd NA 24.56 L/kg 1compartment NA NA Human Human -DTXSID0020101 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID0020101 TK.Half.Life NA 53320 hours 1compartment NA NA Human Human -DTXSID0020101 Css NA 68.24 mg/L 3compartmentss NA 50% Human Human -DTXSID0020101 Css NA 341.2 mg/L 3compartmentss NA 95% Human Human -DTXSID0020101 Css NA 179.4 mg/L PBTK NA 50% Human Human -DTXSID0020101 Css NA 825.8 mg/L PBTK NA 95% Human Human -DTXSID0020101 Clint NA 0.2799 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020101 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020101 Vd NA 20.1 L/kg 1compartment NA NA Rat Human -DTXSID0020101 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID0020101 TK.Half.Life NA 7098 hours 1compartment NA NA Rat Human -DTXSID0020101 Css NA 34.25 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020101 Css NA 113.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020101 Css NA 92.42 mg/L PBTK NA 50% Rat Human -DTXSID0020101 Css NA 296.9 mg/L PBTK NA 95% Rat Human -DTXSID0020103 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020103 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020103 Vd NA 0.8565 L/kg 1compartment NA NA Human Human -DTXSID0020103 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020103 TK.Half.Life NA 5.554 hours 1compartment NA NA Human Human -DTXSID0020103 Css NA 0.81 mg/L 3compartmentss NA 50% Human Human -DTXSID0020103 Css NA 5.684 mg/L 3compartmentss NA 95% Human Human -DTXSID0020103 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID0020103 Css NA 3.687 mg/L PBTK NA 95% Human Human -DTXSID0020103 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020103 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020103 Vd NA 0.8834 L/kg 1compartment NA NA Rat Human -DTXSID0020103 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020103 TK.Half.Life NA 1.949 hours 1compartment NA NA Rat Human -DTXSID0020103 Css NA 0.2033 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020103 Css NA 1.242 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020103 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID0020103 Css NA 0.7575 mg/L PBTK NA 95% Rat Human -DTXSID0020105 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020105 Fup NA 0.781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020105 Vd NA 0.412 L/kg 1compartment NA NA Human Human +DTXSID0020076 TK.Half.Life NA 0.9998 hours 1compartment NA NA Rat Human +DTXSID0020076 Css NA 0.00642 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020076 Css NA 0.05694 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020076 Css NA 0.005318 mg/L PBTK NA 50% Rat Human +DTXSID0020076 Css NA 0.0368 mg/L PBTK NA 95% Rat Human +DTXSID0020105 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020105 Fup 0.806 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020105 Vd NA 0.4432 L/kg 1compartment NA NA Human Human DTXSID0020105 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020105 TK.Half.Life NA 3.413 hours 1compartment NA NA Human Human -DTXSID0020105 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID0020105 Css NA 6.477 mg/L 3compartmentss NA 95% Human Human -DTXSID0020105 Css NA 0.8255 mg/L PBTK NA 50% Human Human -DTXSID0020105 Css NA 3.964 mg/L PBTK NA 95% Human Human -DTXSID0020105 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020105 Fup NA 0.781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020105 Vd NA 0.4371 L/kg 1compartment NA NA Rat Human +DTXSID0020105 TK.Half.Life NA 3.558 hours 1compartment NA NA Human Human +DTXSID0020105 Css NA 0.9552 mg/L 3compartmentss NA 50% Human Human +DTXSID0020105 Css NA 5.414 mg/L 3compartmentss NA 95% Human Human +DTXSID0020105 Css NA 0.701 mg/L PBTK NA 50% Human Human +DTXSID0020105 Css NA 3.373 mg/L PBTK NA 95% Human Human +DTXSID0020105 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020105 Fup 0.806 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020105 Vd NA 0.4652 L/kg 1compartment NA NA Rat Human DTXSID0020105 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020105 TK.Half.Life NA 1.234 hours 1compartment NA NA Rat Human -DTXSID0020105 Css NA 0.298 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020105 Css NA 1.658 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020105 Css NA 0.2056 mg/L PBTK NA 50% Rat Human -DTXSID0020105 Css NA 0.9495 mg/L PBTK NA 95% Rat Human -DTXSID0020107 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020107 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020107 Vd NA 1.465 L/kg 1compartment NA NA Human Human +DTXSID0020105 TK.Half.Life NA 1.273 hours 1compartment NA NA Rat Human +DTXSID0020105 Css NA 0.02509 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020105 Css NA 0.1567 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020105 Css NA 0.01766 mg/L PBTK NA 50% Rat Human +DTXSID0020105 Css NA 0.09591 mg/L PBTK NA 95% Rat Human +DTXSID0020107 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020107 Fup 0.555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020107 Vd NA 0.4928 L/kg 1compartment NA NA Human Human DTXSID0020107 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020107 TK.Half.Life NA 9.481 hours 1compartment NA NA Human Human -DTXSID0020107 Css NA 0.7439 mg/L 3compartmentss NA 50% Human Human -DTXSID0020107 Css NA 5.343 mg/L 3compartmentss NA 95% Human Human -DTXSID0020107 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID0020107 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID0020107 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020107 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020107 Vd NA 1.502 L/kg 1compartment NA NA Rat Human +DTXSID0020107 TK.Half.Life NA 5.747 hours 1compartment NA NA Human Human +DTXSID0020107 Css NA 0.7703 mg/L 3compartmentss NA 50% Human Human +DTXSID0020107 Css NA 5.299 mg/L 3compartmentss NA 95% Human Human +DTXSID0020107 Css NA 0.57 mg/L PBTK NA 50% Human Human +DTXSID0020107 Css NA 3.292 mg/L PBTK NA 95% Human Human +DTXSID0020107 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020107 Fup 0.555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020107 Vd NA 0.5122 L/kg 1compartment NA NA Rat Human DTXSID0020107 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020107 TK.Half.Life NA 3.312 hours 1compartment NA NA Rat Human -DTXSID0020107 Css NA 0.1847 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020107 Css NA 1.282 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020107 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID0020107 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0020151 Clint NA 7.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020151 Fup NA 0.3803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020151 Vd NA 1.492 L/kg 1compartment NA NA Human Human +DTXSID0020107 TK.Half.Life NA 2.036 hours 1compartment NA NA Rat Human +DTXSID0020107 Css NA 0.004044 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020107 Css NA 0.02857 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020107 Css NA 0.002872 mg/L PBTK NA 50% Rat Human +DTXSID0020107 Css NA 0.01686 mg/L PBTK NA 95% Rat Human +DTXSID00201257 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00201257 Fup 0.071 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00201257 Vd NA 1.279 L/kg 1compartment NA NA Human Human +DTXSID00201257 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00201257 TK.Half.Life NA 4.469 hours 1compartment NA NA Human Human +DTXSID00201257 Css NA 0.3806 mg/L 3compartmentss NA 50% Human Human +DTXSID00201257 Css NA 2.652 mg/L 3compartmentss NA 95% Human Human +DTXSID00201257 Css NA 0.2465 mg/L PBTK NA 50% Human Human +DTXSID00201257 Css NA 1.654 mg/L PBTK NA 95% Human Human +DTXSID00201257 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00201257 Fup 0.071 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00201257 Vd NA 0.9699 L/kg 1compartment NA NA Rat Human +DTXSID00201257 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00201257 TK.Half.Life NA 1.813 hours 1compartment NA NA Rat Human +DTXSID00201257 Css NA 0.05008 mg/L 3compartmentss NA 50% Rat Human +DTXSID00201257 Css NA 0.2629 mg/L 3compartmentss NA 95% Rat Human +DTXSID00201257 Css NA 0.03148 mg/L PBTK NA 50% Rat Human +DTXSID00201257 Css NA 0.1622 mg/L PBTK NA 95% Rat Human +DTXSID0020151 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020151 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020151 Vd NA 1.36 L/kg 1compartment NA NA Human Human DTXSID0020151 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020151 TK.Half.Life NA 3.171 hours 1compartment NA NA Human Human -DTXSID0020151 Css NA 0.1729 mg/L 3compartmentss NA 50% Human Human -DTXSID0020151 Css NA 1.136 mg/L 3compartmentss NA 95% Human Human -DTXSID0020151 Css NA 0.1363 mg/L PBTK NA 50% Human Human -DTXSID0020151 Css NA 0.7967 mg/L PBTK NA 95% Human Human -DTXSID0020151 Clint NA 7.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020151 Fup NA 0.3803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020151 Vd NA 1.231 L/kg 1compartment NA NA Rat Human +DTXSID0020151 TK.Half.Life NA 1.778 hours 1compartment NA NA Human Human +DTXSID0020151 Css NA 0.06962 mg/L 3compartmentss NA 50% Human Human +DTXSID0020151 Css NA 0.4968 mg/L 3compartmentss NA 95% Human Human +DTXSID0020151 Css NA 0.05287 mg/L PBTK NA 50% Human Human +DTXSID0020151 Css NA 0.3468 mg/L PBTK NA 95% Human Human +DTXSID0020151 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020151 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020151 Vd NA 1.119 L/kg 1compartment NA NA Rat Human DTXSID0020151 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020151 TK.Half.Life NA 1.314 hours 1compartment NA NA Rat Human -DTXSID0020151 Css NA 0.08776 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020151 Css NA 0.413 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020151 Css NA 0.06695 mg/L PBTK NA 50% Rat Human -DTXSID0020151 Css NA 0.2738 mg/L PBTK NA 95% Rat Human -DTXSID0020157 Clint NA 2.434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020157 Fup NA 0.7756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020157 Vd NA 2.745 L/kg 1compartment NA NA Human Human +DTXSID0020151 TK.Half.Life NA 0.729 hours 1compartment NA NA Rat Human +DTXSID0020151 Css NA 0.008581 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020151 Css NA 0.04836 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020151 Css NA 0.006552 mg/L PBTK NA 50% Rat Human +DTXSID0020151 Css NA 0.03343 mg/L PBTK NA 95% Rat Human +DTXSID0020155 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020155 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020155 Vd NA 2.134 L/kg 1compartment NA NA Human Human +DTXSID0020155 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0020155 TK.Half.Life NA 7.392 hours 1compartment NA NA Human Human +DTXSID0020155 Css NA 0.3772 mg/L 3compartmentss NA 50% Human Human +DTXSID0020155 Css NA 2.721 mg/L 3compartmentss NA 95% Human Human +DTXSID0020155 Css NA 0.257 mg/L PBTK NA 50% Human Human +DTXSID0020155 Css NA 1.767 mg/L PBTK NA 95% Human Human +DTXSID0020155 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020155 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020155 Vd NA 1.614 L/kg 1compartment NA NA Rat Human +DTXSID0020155 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0020155 TK.Half.Life NA 2.331 hours 1compartment NA NA Rat Human +DTXSID0020155 Css NA 0.04891 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020155 Css NA 0.2668 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020155 Css NA 0.03275 mg/L PBTK NA 50% Rat Human +DTXSID0020155 Css NA 0.1696 mg/L PBTK NA 95% Rat Human +DTXSID0020157 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020157 Fup 0.643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020157 Vd NA 2.25 L/kg 1compartment NA NA Human Human DTXSID0020157 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020157 TK.Half.Life NA 5.299 hours 1compartment NA NA Human Human -DTXSID0020157 Css NA 0.1547 mg/L 3compartmentss NA 50% Human Human -DTXSID0020157 Css NA 1.392 mg/L 3compartmentss NA 95% Human Human -DTXSID0020157 Css NA 0.1716 mg/L PBTK NA 50% Human Human -DTXSID0020157 Css NA 1.047 mg/L PBTK NA 95% Human Human -DTXSID0020157 Clint NA 2.434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020157 Fup NA 0.7756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020157 Vd NA 2.791 L/kg 1compartment NA NA Rat Human +DTXSID0020157 TK.Half.Life NA 2.906 hours 1compartment NA NA Human Human +DTXSID0020157 Css NA 0.08138 mg/L 3compartmentss NA 50% Human Human +DTXSID0020157 Css NA 0.8505 mg/L 3compartmentss NA 95% Human Human +DTXSID0020157 Css NA 0.0833 mg/L PBTK NA 50% Human Human +DTXSID0020157 Css NA 0.6401 mg/L PBTK NA 95% Human Human +DTXSID0020157 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020157 Fup 0.643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020157 Vd NA 2.282 L/kg 1compartment NA NA Rat Human DTXSID0020157 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020157 TK.Half.Life NA 2.904 hours 1compartment NA NA Rat Human -DTXSID0020157 Css NA 0.06547 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020157 Css NA 0.5527 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020157 Css NA 0.0736 mg/L PBTK NA 50% Rat Human -DTXSID0020157 Css NA 0.3729 mg/L PBTK NA 95% Rat Human +DTXSID0020157 TK.Half.Life NA 1.633 hours 1compartment NA NA Rat Human +DTXSID0020157 Css NA 0.009046 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020157 Css NA 0.08627 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020157 Css NA 0.009605 mg/L PBTK NA 50% Rat Human +DTXSID0020157 Css NA 0.05954 mg/L PBTK NA 95% Rat Human DTXSID0020232 Clint 0.2855 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID0020232 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID0020232 Vd NA 0.9302 L/kg 1compartment NA NA Human Human DTXSID0020232 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0020232 TK.Half.Life NA 4.161 hours 1compartment NA NA Human Human -DTXSID0020232 Css NA 0.4494 mg/L 3compartmentss NA 50% Human Human -DTXSID0020232 Css NA 1.325 mg/L 3compartmentss NA 95% Human Human -DTXSID0020232 Css NA 0.4351 mg/L PBTK NA 50% Human Human -DTXSID0020232 Css NA 1.117 mg/L PBTK NA 95% Human Human +DTXSID0020232 Css NA 0.3962 mg/L 3compartmentss NA 50% Human Human +DTXSID0020232 Css NA 1.014 mg/L 3compartmentss NA 95% Human Human +DTXSID0020232 Css NA 0.4269 mg/L PBTK NA 50% Human Human +DTXSID0020232 Css NA 1.094 mg/L PBTK NA 95% Human Human DTXSID0020232 Clint 1.458 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID0020232 Fup 0.7335 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0020232 Vd NA 0.7805 L/kg 1compartment NA NA Rat Rat DTXSID0020232 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID0020232 TK.Half.Life NA 1.131 hours 1compartment NA NA Rat Rat -DTXSID0020232 Css NA 0.1016 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0020232 Css NA 0.7598 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0020232 Css NA 0.1023 mg/L PBTK NA 50% Rat Rat -DTXSID0020232 Css NA 0.4914 mg/L PBTK NA 95% Rat Rat +DTXSID0020232 Css NA 0.02137 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0020232 Css NA 0.1067 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0020232 Css NA 0.0239 mg/L PBTK NA 50% Rat Rat +DTXSID0020232 Css NA 0.1193 mg/L PBTK NA 95% Rat Rat DTXSID0020236 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020236 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020236 Vd NA 0.4375 L/kg 1compartment NA NA Human Human +DTXSID0020236 Vd NA 0.392 L/kg 1compartment NA NA Human Human DTXSID0020236 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020236 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID0020236 Css NA 1.56 mg/L 3compartmentss NA 50% Human Human -DTXSID0020236 Css NA 7.454 mg/L 3compartmentss NA 95% Human Human -DTXSID0020236 Css NA 1.134 mg/L PBTK NA 50% Human Human -DTXSID0020236 Css NA 4.649 mg/L PBTK NA 95% Human Human +DTXSID0020236 TK.Half.Life NA 5.243 hours 1compartment NA NA Human Human +DTXSID0020236 Css NA 1.342 mg/L 3compartmentss NA 50% Human Human +DTXSID0020236 Css NA 6.475 mg/L 3compartmentss NA 95% Human Human +DTXSID0020236 Css NA 0.9592 mg/L PBTK NA 50% Human Human +DTXSID0020236 Css NA 4.025 mg/L PBTK NA 95% Human Human DTXSID0020236 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020236 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020236 Vd NA 0.4563 L/kg 1compartment NA NA Rat Human +DTXSID0020236 Vd NA 0.4182 L/kg 1compartment NA NA Rat Human DTXSID0020236 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020236 TK.Half.Life NA 2.08 hours 1compartment NA NA Rat Human -DTXSID0020236 Css NA 0.4248 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020236 Css NA 1.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020236 Css NA 0.2941 mg/L PBTK NA 50% Rat Human -DTXSID0020236 Css NA 1.038 mg/L PBTK NA 95% Rat Human -DTXSID0020238 Clint NA 9.044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020238 Fup NA 0.4688 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020238 Vd NA 2.207 L/kg 1compartment NA NA Human Human +DTXSID0020236 TK.Half.Life NA 1.906 hours 1compartment NA NA Rat Human +DTXSID0020236 Css NA 0.02511 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020236 Css NA 0.1663 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020236 Css NA 0.01723 mg/L PBTK NA 50% Rat Human +DTXSID0020236 Css NA 0.1023 mg/L PBTK NA 95% Rat Human +DTXSID0020238 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020238 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020238 Vd NA 0.3555 L/kg 1compartment NA NA Human Human DTXSID0020238 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020238 TK.Half.Life NA 2.768 hours 1compartment NA NA Human Human -DTXSID0020238 Css NA 0.07002 mg/L 3compartmentss NA 50% Human Human -DTXSID0020238 Css NA 0.628 mg/L 3compartmentss NA 95% Human Human -DTXSID0020238 Css NA 0.07451 mg/L PBTK NA 50% Human Human -DTXSID0020238 Css NA 0.5048 mg/L PBTK NA 95% Human Human -DTXSID0020238 Clint NA 9.044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020238 Fup NA 0.4688 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020238 Vd NA 2.184 L/kg 1compartment NA NA Rat Human +DTXSID0020238 TK.Half.Life NA 1.001 hours 1compartment NA NA Human Human +DTXSID0020238 Css NA 0.1385 mg/L 3compartmentss NA 50% Human Human +DTXSID0020238 Css NA 0.919 mg/L 3compartmentss NA 95% Human Human +DTXSID0020238 Css NA 0.09236 mg/L PBTK NA 50% Human Human +DTXSID0020238 Css NA 0.5809 mg/L PBTK NA 95% Human Human +DTXSID0020238 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020238 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020238 Vd NA 0.3732 L/kg 1compartment NA NA Rat Human DTXSID0020238 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020238 TK.Half.Life NA 1.547 hours 1compartment NA NA Rat Human -DTXSID0020238 Css NA 0.03504 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020238 Css NA 0.2547 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020238 Css NA 0.03675 mg/L PBTK NA 50% Rat Human -DTXSID0020238 Css NA 0.193 mg/L PBTK NA 95% Rat Human -DTXSID0020280 Clint NA 5.999 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020280 Fup NA 0.2874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020280 Vd NA 1.621 L/kg 1compartment NA NA Human Human +DTXSID0020238 TK.Half.Life NA 0.6038 hours 1compartment NA NA Rat Human +DTXSID0020238 Css NA 0.001319 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020238 Css NA 0.007972 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020238 Css NA 0.0008369 mg/L PBTK NA 50% Rat Human +DTXSID0020238 Css NA 0.004661 mg/L PBTK NA 95% Rat Human +DTXSID0020280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020280 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020280 Vd NA 1.064 L/kg 1compartment NA NA Human Human DTXSID0020280 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020280 TK.Half.Life NA 5.161 hours 1compartment NA NA Human Human -DTXSID0020280 Css NA 0.2985 mg/L 3compartmentss NA 50% Human Human -DTXSID0020280 Css NA 1.704 mg/L 3compartmentss NA 95% Human Human -DTXSID0020280 Css NA 0.2258 mg/L PBTK NA 50% Human Human -DTXSID0020280 Css NA 1.19 mg/L PBTK NA 95% Human Human -DTXSID0020280 Clint NA 5.999 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020280 Fup NA 0.2874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020280 Vd NA 1.296 L/kg 1compartment NA NA Rat Human +DTXSID0020280 TK.Half.Life NA 2.444 hours 1compartment NA NA Human Human +DTXSID0020280 Css NA 0.191 mg/L 3compartmentss NA 50% Human Human +DTXSID0020280 Css NA 1.665 mg/L 3compartmentss NA 95% Human Human +DTXSID0020280 Css NA 0.1264 mg/L PBTK NA 50% Human Human +DTXSID0020280 Css NA 1.045 mg/L PBTK NA 95% Human Human +DTXSID0020280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020280 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020280 Vd NA 0.8425 L/kg 1compartment NA NA Rat Human DTXSID0020280 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020280 TK.Half.Life NA 2.003 hours 1compartment NA NA Rat Human -DTXSID0020280 Css NA 0.1534 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020280 Css NA 0.6433 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020280 Css NA 0.1113 mg/L PBTK NA 50% Rat Human -DTXSID0020280 Css NA 0.4184 mg/L PBTK NA 95% Rat Human -DTXSID0020282 Clint NA 1.083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020282 Fup NA 0.6157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020282 Vd NA 0.9525 L/kg 1compartment NA NA Human Human +DTXSID0020280 TK.Half.Life NA 1.054 hours 1compartment NA NA Rat Human +DTXSID0020280 Css NA 0.009388 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020280 Css NA 0.08518 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020280 Css NA 0.00602 mg/L PBTK NA 50% Rat Human +DTXSID0020280 Css NA 0.0516 mg/L PBTK NA 95% Rat Human +DTXSID0020282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020282 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020282 Vd NA 0.7137 L/kg 1compartment NA NA Human Human DTXSID0020282 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020282 TK.Half.Life NA 3.916 hours 1compartment NA NA Human Human -DTXSID0020282 Css NA 0.4272 mg/L 3compartmentss NA 50% Human Human -DTXSID0020282 Css NA 3.049 mg/L 3compartmentss NA 95% Human Human -DTXSID0020282 Css NA 0.3552 mg/L PBTK NA 50% Human Human -DTXSID0020282 Css NA 1.968 mg/L PBTK NA 95% Human Human -DTXSID0020282 Clint NA 1.083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020282 Fup NA 0.6157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020282 Vd NA 0.9041 L/kg 1compartment NA NA Rat Human +DTXSID0020282 TK.Half.Life NA 0.8176 hours 1compartment NA NA Human Human +DTXSID0020282 Css NA 0.0508 mg/L 3compartmentss NA 50% Human Human +DTXSID0020282 Css NA 0.4071 mg/L 3compartmentss NA 95% Human Human +DTXSID0020282 Css NA 0.03802 mg/L PBTK NA 50% Human Human +DTXSID0020282 Css NA 0.2804 mg/L PBTK NA 95% Human Human +DTXSID0020282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020282 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020282 Vd NA 0.676 L/kg 1compartment NA NA Rat Human DTXSID0020282 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020282 TK.Half.Life NA 1.788 hours 1compartment NA NA Rat Human -DTXSID0020282 Css NA 0.1669 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020282 Css NA 1.113 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020282 Css NA 0.1356 mg/L PBTK NA 50% Rat Human -DTXSID0020282 Css NA 0.669 mg/L PBTK NA 95% Rat Human -DTXSID0020284 Clint NA 3.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020284 Fup NA 0.6087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020284 Vd NA 1.01 L/kg 1compartment NA NA Human Human +DTXSID0020282 TK.Half.Life NA 0.3997 hours 1compartment NA NA Rat Human +DTXSID0020282 Css NA 0.006307 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020282 Css NA 0.03989 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020282 Css NA 0.004707 mg/L PBTK NA 50% Rat Human +DTXSID0020282 Css NA 0.02598 mg/L PBTK NA 95% Rat Human +DTXSID0020284 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020284 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020284 Vd NA 0.5675 L/kg 1compartment NA NA Human Human DTXSID0020284 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020284 TK.Half.Life NA 1.998 hours 1compartment NA NA Human Human -DTXSID0020284 Css NA 0.1744 mg/L 3compartmentss NA 50% Human Human -DTXSID0020284 Css NA 1.463 mg/L 3compartmentss NA 95% Human Human -DTXSID0020284 Css NA 0.1451 mg/L PBTK NA 50% Human Human -DTXSID0020284 Css NA 0.9652 mg/L PBTK NA 95% Human Human -DTXSID0020284 Clint NA 3.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020284 Fup NA 0.6087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020284 Vd NA 0.9447 L/kg 1compartment NA NA Rat Human +DTXSID0020284 TK.Half.Life NA 0.6508 hours 1compartment NA NA Human Human +DTXSID0020284 Css NA 0.05088 mg/L 3compartmentss NA 50% Human Human +DTXSID0020284 Css NA 0.3918 mg/L 3compartmentss NA 95% Human Human +DTXSID0020284 Css NA 0.0371 mg/L PBTK NA 50% Human Human +DTXSID0020284 Css NA 0.2628 mg/L PBTK NA 95% Human Human +DTXSID0020284 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020284 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020284 Vd NA 0.5671 L/kg 1compartment NA NA Rat Human DTXSID0020284 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020284 TK.Half.Life NA 0.9959 hours 1compartment NA NA Rat Human -DTXSID0020284 Css NA 0.08091 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020284 Css NA 0.602 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020284 Css NA 0.06554 mg/L PBTK NA 50% Rat Human -DTXSID0020284 Css NA 0.366 mg/L PBTK NA 95% Rat Human +DTXSID0020284 TK.Half.Life NA 0.3353 hours 1compartment NA NA Rat Human +DTXSID0020284 Css NA 0.006209 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020284 Css NA 0.04033 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020284 Css NA 0.004545 mg/L PBTK NA 50% Rat Human +DTXSID0020284 Css NA 0.02617 mg/L PBTK NA 95% Rat Human DTXSID0020286 Clint 65.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0020286 Fup 0.145 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0020286 Vd NA 0.8762 L/kg 1compartment NA NA Human Human +DTXSID0020286 Vd NA 1.223 L/kg 1compartment NA NA Human Human DTXSID0020286 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020286 TK.Half.Life NA 1.084 hours 1compartment NA NA Human Human -DTXSID0020286 Css NA 0.04951 mg/L 3compartmentss NA 50% Human Human -DTXSID0020286 Css NA 0.3215 mg/L 3compartmentss NA 95% Human Human -DTXSID0020286 Css NA 0.03368 mg/L PBTK NA 50% Human Human -DTXSID0020286 Css NA 0.2082 mg/L PBTK NA 95% Human Human +DTXSID0020286 TK.Half.Life NA 1.529 hours 1compartment NA NA Human Human +DTXSID0020286 Css NA 0.04832 mg/L 3compartmentss NA 50% Human Human +DTXSID0020286 Css NA 0.33 mg/L 3compartmentss NA 95% Human Human +DTXSID0020286 Css NA 0.03348 mg/L PBTK NA 50% Human Human +DTXSID0020286 Css NA 0.2208 mg/L PBTK NA 95% Human Human DTXSID0020286 Clint 65.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0020286 Fup 0.145 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0020286 Vd NA 0.7182 L/kg 1compartment NA NA Rat Human +DTXSID0020286 Vd NA 0.9658 L/kg 1compartment NA NA Rat Human DTXSID0020286 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020286 TK.Half.Life NA 0.4472 hours 1compartment NA NA Rat Human -DTXSID0020286 Css NA 0.0276 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020286 Css NA 0.1458 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020286 Css NA 0.01776 mg/L PBTK NA 50% Rat Human -DTXSID0020286 Css NA 0.09154 mg/L PBTK NA 95% Rat Human -DTXSID0020288 Clint NA 15.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020288 Fup NA 0.2773 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020288 Vd NA 1.462 L/kg 1compartment NA NA Human Human +DTXSID0020286 TK.Half.Life NA 0.5929 hours 1compartment NA NA Rat Human +DTXSID0020286 Css NA 0.006354 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020286 Css NA 0.03559 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020286 Css NA 0.004322 mg/L PBTK NA 50% Rat Human +DTXSID0020286 Css NA 0.02343 mg/L PBTK NA 95% Rat Human +DTXSID0020288 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020288 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020288 Vd NA 0.9759 L/kg 1compartment NA NA Human Human DTXSID0020288 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020288 TK.Half.Life NA 2.463 hours 1compartment NA NA Human Human -DTXSID0020288 Css NA 0.1186 mg/L 3compartmentss NA 50% Human Human -DTXSID0020288 Css NA 0.7942 mg/L 3compartmentss NA 95% Human Human -DTXSID0020288 Css NA 0.08836 mg/L PBTK NA 50% Human Human -DTXSID0020288 Css NA 0.543 mg/L PBTK NA 95% Human Human -DTXSID0020288 Clint NA 15.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020288 Fup NA 0.2773 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020288 Vd NA 1.182 L/kg 1compartment NA NA Rat Human +DTXSID0020288 TK.Half.Life NA 2.522 hours 1compartment NA NA Human Human +DTXSID0020288 Css NA 0.2738 mg/L 3compartmentss NA 50% Human Human +DTXSID0020288 Css NA 2.197 mg/L 3compartmentss NA 95% Human Human +DTXSID0020288 Css NA 0.1777 mg/L PBTK NA 50% Human Human +DTXSID0020288 Css NA 1.361 mg/L PBTK NA 95% Human Human +DTXSID0020288 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020288 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020288 Vd NA 0.7717 L/kg 1compartment NA NA Rat Human DTXSID0020288 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020288 TK.Half.Life NA 0.9978 hours 1compartment NA NA Rat Human -DTXSID0020288 Css NA 0.06324 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020288 Css NA 0.3169 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020288 Css NA 0.04566 mg/L PBTK NA 50% Rat Human -DTXSID0020288 Css NA 0.208 mg/L PBTK NA 95% Rat Human +DTXSID0020288 TK.Half.Life NA 1.112 hours 1compartment NA NA Rat Human +DTXSID0020288 Css NA 0.03582 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020288 Css NA 0.2195 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020288 Css NA 0.02267 mg/L PBTK NA 50% Rat Human +DTXSID0020288 Css NA 0.1322 mg/L PBTK NA 95% Rat Human DTXSID0020311 Clint 3.086 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0020311 Fup 0.4551 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0020311 Vd NA 1.608 L/kg 1compartment NA NA Human Human DTXSID0020311 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0020311 TK.Half.Life NA 5.32 hours 1compartment NA NA Human Human -DTXSID0020311 Css NA 0.3018 mg/L 3compartmentss NA 50% Human Human -DTXSID0020311 Css NA 1.851 mg/L 3compartmentss NA 95% Human Human -DTXSID0020311 Css NA 0.2484 mg/L PBTK NA 50% Human Human -DTXSID0020311 Css NA 1.312 mg/L PBTK NA 95% Human Human +DTXSID0020311 Css NA 0.2948 mg/L 3compartmentss NA 50% Human Human +DTXSID0020311 Css NA 1.787 mg/L 3compartmentss NA 95% Human Human +DTXSID0020311 Css NA 0.2419 mg/L PBTK NA 50% Human Human +DTXSID0020311 Css NA 1.235 mg/L PBTK NA 95% Human Human DTXSID0020311 Clint 3.086 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0020311 Fup 0.4551 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0020311 Vd NA 1.332 L/kg 1compartment NA NA Rat Human DTXSID0020311 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0020311 TK.Half.Life NA 2.091 hours 1compartment NA NA Rat Human -DTXSID0020311 Css NA 0.1438 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020311 Css NA 0.6664 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020311 Css NA 0.1141 mg/L PBTK NA 50% Rat Human -DTXSID0020311 Css NA 0.43 mg/L PBTK NA 95% Rat Human +DTXSID0020311 Css NA 0.03208 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020311 Css NA 0.1517 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020311 Css NA 0.02666 mg/L PBTK NA 50% Rat Human +DTXSID0020311 Css NA 0.1007 mg/L PBTK NA 95% Rat Human DTXSID0020319 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0020319 Fup 0.378 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0020319 Vd NA 2.703 L/kg 1compartment NA NA Human Human DTXSID0020319 Days.Css NA 33 Days PBTK NA NA Human Human DTXSID0020319 TK.Half.Life NA 168.2 hours 1compartment NA NA Human Human -DTXSID0020319 Css NA 6.626 mg/L 3compartmentss NA 50% Human Human -DTXSID0020319 Css NA 20.22 mg/L 3compartmentss NA 95% Human Human -DTXSID0020319 Css NA 5.024 mg/L PBTK NA 50% Human Human -DTXSID0020319 Css NA 13.76 mg/L PBTK NA 95% Human Human +DTXSID0020319 Css NA 6.413 mg/L 3compartmentss NA 50% Human Human +DTXSID0020319 Css NA 19.51 mg/L 3compartmentss NA 95% Human Human +DTXSID0020319 Css NA 4.862 mg/L PBTK NA 50% Human Human +DTXSID0020319 Css NA 13.28 mg/L PBTK NA 95% Human Human DTXSID0020319 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0020319 Fup 0.378 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0020319 Vd NA 2.076 L/kg 1compartment NA NA Rat Human DTXSID0020319 Days.Css NA 7 Days PBTK NA NA Rat Human DTXSID0020319 TK.Half.Life NA 19.71 hours 1compartment NA NA Rat Human -DTXSID0020319 Css NA 1.833 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020319 Css NA 4.467 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020319 Css NA 1.344 mg/L PBTK NA 50% Rat Human -DTXSID0020319 Css NA 2.824 mg/L PBTK NA 95% Rat Human +DTXSID0020319 Css NA 0.4152 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020319 Css NA 0.9854 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020319 Css NA 0.315 mg/L PBTK NA 50% Rat Human +DTXSID0020319 Css NA 0.6474 mg/L PBTK NA 95% Rat Human DTXSID0020361 Clint NA 1.413 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020361 Fup NA 0.6994 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020361 Vd NA 2.433 L/kg 1compartment NA NA Human Human +DTXSID0020361 Vd NA 1.343 L/kg 1compartment NA NA Human Human DTXSID0020361 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020361 TK.Half.Life NA 7.107 hours 1compartment NA NA Human Human -DTXSID0020361 Css NA 0.2356 mg/L 3compartmentss NA 50% Human Human -DTXSID0020361 Css NA 2.085 mg/L 3compartmentss NA 95% Human Human -DTXSID0020361 Css NA 0.2689 mg/L PBTK NA 50% Human Human -DTXSID0020361 Css NA 1.52 mg/L PBTK NA 95% Human Human +DTXSID0020361 TK.Half.Life NA 4.089 hours 1compartment NA NA Human Human +DTXSID0020361 Css NA 0.251 mg/L 3compartmentss NA 50% Human Human +DTXSID0020361 Css NA 1.945 mg/L 3compartmentss NA 95% Human Human +DTXSID0020361 Css NA 0.229 mg/L PBTK NA 50% Human Human +DTXSID0020361 Css NA 1.334 mg/L PBTK NA 95% Human Human DTXSID0020361 Clint NA 1.413 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020361 Fup NA 0.6994 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020361 Vd NA 2.413 L/kg 1compartment NA NA Rat Human +DTXSID0020361 Vd NA 1.336 L/kg 1compartment NA NA Rat Human DTXSID0020361 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020361 TK.Half.Life NA 3.631 hours 1compartment NA NA Rat Human -DTXSID0020361 Css NA 0.09191 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020361 Css NA 0.8077 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020361 Css NA 0.1052 mg/L PBTK NA 50% Rat Human -DTXSID0020361 Css NA 0.5429 mg/L PBTK NA 95% Rat Human +DTXSID0020361 TK.Half.Life NA 2.065 hours 1compartment NA NA Rat Human +DTXSID0020361 Css NA 0.007194 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020361 Css NA 0.06873 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020361 Css NA 0.006384 mg/L PBTK NA 50% Rat Human +DTXSID0020361 Css NA 0.04672 mg/L PBTK NA 95% Rat Human DTXSID0020363 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020363 Fup NA 0.8646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020363 Vd NA 0.7197 L/kg 1compartment NA NA Human Human +DTXSID0020363 Vd NA 0.5432 L/kg 1compartment NA NA Human Human DTXSID0020363 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020363 TK.Half.Life NA 5.436 hours 1compartment NA NA Human Human -DTXSID0020363 Css NA 0.9666 mg/L 3compartmentss NA 50% Human Human -DTXSID0020363 Css NA 5.473 mg/L 3compartmentss NA 95% Human Human -DTXSID0020363 Css NA 0.7815 mg/L PBTK NA 50% Human Human -DTXSID0020363 Css NA 3.537 mg/L PBTK NA 95% Human Human +DTXSID0020363 TK.Half.Life NA 4.065 hours 1compartment NA NA Human Human +DTXSID0020363 Css NA 0.8684 mg/L 3compartmentss NA 50% Human Human +DTXSID0020363 Css NA 4.816 mg/L 3compartmentss NA 95% Human Human +DTXSID0020363 Css NA 0.6618 mg/L PBTK NA 50% Human Human +DTXSID0020363 Css NA 3.056 mg/L PBTK NA 95% Human Human DTXSID0020363 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020363 Fup NA 0.8646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020363 Vd NA 0.7109 L/kg 1compartment NA NA Rat Human +DTXSID0020363 Vd NA 0.5621 L/kg 1compartment NA NA Rat Human DTXSID0020363 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020363 TK.Half.Life NA 1.817 hours 1compartment NA NA Rat Human -DTXSID0020363 Css NA 0.2495 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020363 Css NA 1.439 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020363 Css NA 0.1945 mg/L PBTK NA 50% Rat Human -DTXSID0020363 Css NA 0.8556 mg/L PBTK NA 95% Rat Human +DTXSID0020363 TK.Half.Life NA 1.434 hours 1compartment NA NA Rat Human +DTXSID0020363 Css NA 0.01652 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020363 Css NA 0.1165 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020363 Css NA 0.01204 mg/L PBTK NA 50% Rat Human +DTXSID0020363 Css NA 0.07321 mg/L PBTK NA 95% Rat Human DTXSID0020365 Clint 8.591 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID0020365 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID0020365 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0020365 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID0020367 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020367 Fup NA 0.8393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020367 Vd NA 0.62 L/kg 1compartment NA NA Human Human +DTXSID0020367 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020367 Fup 0.712 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020367 Vd NA 0.6503 L/kg 1compartment NA NA Human Human DTXSID0020367 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020367 TK.Half.Life NA 4.78 hours 1compartment NA NA Human Human -DTXSID0020367 Css NA 0.9986 mg/L 3compartmentss NA 50% Human Human -DTXSID0020367 Css NA 5.742 mg/L 3compartmentss NA 95% Human Human -DTXSID0020367 Css NA 0.7934 mg/L PBTK NA 50% Human Human -DTXSID0020367 Css NA 3.705 mg/L PBTK NA 95% Human Human -DTXSID0020367 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020367 Fup NA 0.8393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020367 Vd NA 0.6642 L/kg 1compartment NA NA Rat Human +DTXSID0020367 TK.Half.Life NA 5.914 hours 1compartment NA NA Human Human +DTXSID0020367 Css NA 0.9343 mg/L 3compartmentss NA 50% Human Human +DTXSID0020367 Css NA 6.068 mg/L 3compartmentss NA 95% Human Human +DTXSID0020367 Css NA 0.7434 mg/L PBTK NA 50% Human Human +DTXSID0020367 Css NA 3.81 mg/L PBTK NA 95% Human Human +DTXSID0020367 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020367 Fup 0.712 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020367 Vd NA 0.6764 L/kg 1compartment NA NA Rat Human DTXSID0020367 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020367 TK.Half.Life NA 1.745 hours 1compartment NA NA Rat Human -DTXSID0020367 Css NA 0.2574 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020367 Css NA 1.477 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020367 Css NA 0.1978 mg/L PBTK NA 50% Rat Human -DTXSID0020367 Css NA 0.8737 mg/L PBTK NA 95% Rat Human -DTXSID0020369 Clint NA 3.911 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0020367 TK.Half.Life NA 2.095 hours 1compartment NA NA Rat Human +DTXSID0020367 Css NA 0.01764 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020367 Css NA 0.1374 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020367 Css NA 0.0135 mg/L PBTK NA 50% Rat Human +DTXSID0020367 Css NA 0.08767 mg/L PBTK NA 95% Rat Human +DTXSID0020369 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0020369 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0020369 Vd NA 0.5415 L/kg 1compartment NA NA Human Human DTXSID0020369 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020369 TK.Half.Life NA 0.7205 hours 1compartment NA NA Human Human -DTXSID0020369 Css NA 0.1262 mg/L 3compartmentss NA 50% Human Human -DTXSID0020369 Css NA 1.043 mg/L 3compartmentss NA 95% Human Human -DTXSID0020369 Css NA 0.09519 mg/L PBTK NA 50% Human Human -DTXSID0020369 Css NA 0.6951 mg/L PBTK NA 95% Human Human -DTXSID0020369 Clint NA 3.911 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0020369 TK.Half.Life NA 3.504 hours 1compartment NA NA Human Human +DTXSID0020369 Css NA 0.8754 mg/L 3compartmentss NA 50% Human Human +DTXSID0020369 Css NA 5.718 mg/L 3compartmentss NA 95% Human Human +DTXSID0020369 Css NA 0.674 mg/L PBTK NA 50% Human Human +DTXSID0020369 Css NA 3.677 mg/L PBTK NA 95% Human Human +DTXSID0020369 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0020369 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0020369 Vd NA 0.5618 L/kg 1compartment NA NA Rat Human DTXSID0020369 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020369 TK.Half.Life NA 0.3851 hours 1compartment NA NA Rat Human -DTXSID0020369 Css NA 0.05752 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020369 Css NA 0.3757 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020369 Css NA 0.04276 mg/L PBTK NA 50% Rat Human -DTXSID0020369 Css NA 0.2274 mg/L PBTK NA 95% Rat Human +DTXSID0020369 TK.Half.Life NA 1.239 hours 1compartment NA NA Rat Human +DTXSID0020369 Css NA 0.05184 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020369 Css NA 0.2974 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020369 Css NA 0.03998 mg/L PBTK NA 50% Rat Human +DTXSID0020369 Css NA 0.1803 mg/L PBTK NA 95% Rat Human DTXSID0020440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0020440 Fup 0.008529 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID0020440 Vd NA 0.1943 L/kg 1compartment NA NA Human Human -DTXSID0020440 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID0020440 TK.Half.Life NA 147.4 hours 1compartment NA NA Human Human -DTXSID0020440 Css NA 132.4 mg/L 3compartmentss NA 50% Human Human -DTXSID0020440 Css NA 796.2 mg/L 3compartmentss NA 95% Human Human -DTXSID0020440 Css NA 77.72 mg/L PBTK NA 50% Human Human -DTXSID0020440 Css NA 461.8 mg/L PBTK NA 95% Human Human +DTXSID0020440 Vd NA 0.1783 L/kg 1compartment NA NA Human Human +DTXSID0020440 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID0020440 TK.Half.Life NA 135.2 hours 1compartment NA NA Human Human +DTXSID0020440 Css NA 129.1 mg/L 3compartmentss NA 50% Human Human +DTXSID0020440 Css NA 754.1 mg/L 3compartmentss NA 95% Human Human +DTXSID0020440 Css NA 74.87 mg/L PBTK NA 50% Human Human +DTXSID0020440 Css NA 434.7 mg/L PBTK NA 95% Human Human DTXSID0020440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0020440 Fup 0.008529 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID0020440 Vd NA 0.19 L/kg 1compartment NA NA Rat Human -DTXSID0020440 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID0020440 TK.Half.Life NA 49.12 hours 1compartment NA NA Rat Human -DTXSID0020440 Css NA 37.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020440 Css NA 194.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020440 Css NA 20.42 mg/L PBTK NA 50% Rat Human -DTXSID0020440 Css NA 105.3 mg/L PBTK NA 95% Rat Human +DTXSID0020440 Vd NA 0.1759 L/kg 1compartment NA NA Rat Human +DTXSID0020440 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID0020440 TK.Half.Life NA 45.48 hours 1compartment NA NA Rat Human +DTXSID0020440 Css NA 8.402 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020440 Css NA 44.92 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020440 Css NA 4.73 mg/L PBTK NA 50% Rat Human +DTXSID0020440 Css NA 25.16 mg/L PBTK NA 95% Rat Human DTXSID0020442 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0020442 Fup 0.04001 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0020442 Vd NA 0.2989 L/kg 1compartment NA NA Human Human DTXSID0020442 Days.Css NA 13 Days PBTK NA NA Human Human DTXSID0020442 TK.Half.Life NA 48.34 hours 1compartment NA NA Human Human -DTXSID0020442 Css NA 9.877 mg/L 3compartmentss NA 50% Human Human -DTXSID0020442 Css NA 112.3 mg/L 3compartmentss NA 95% Human Human -DTXSID0020442 Css NA 16.77 mg/L PBTK NA 50% Human Human -DTXSID0020442 Css NA 95.36 mg/L PBTK NA 95% Human Human +DTXSID0020442 Css NA 7.632 mg/L 3compartmentss NA 50% Human Human +DTXSID0020442 Css NA 43.33 mg/L 3compartmentss NA 95% Human Human +DTXSID0020442 Css NA 16.1 mg/L PBTK NA 50% Human Human +DTXSID0020442 Css NA 91.43 mg/L PBTK NA 95% Human Human DTXSID0020442 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0020442 Fup 0.02976 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID0020442 Vd NA 0.2618 L/kg 1compartment NA NA Rat Rat +DTXSID0020442 Vd 0.21 0.2618 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID0020442 Days.Css NA 4 Days PBTK NA NA Rat Rat -DTXSID0020442 TK.Half.Life NA 19.39 hours 1compartment NA NA Rat Rat -DTXSID0020442 Css NA 3.342 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0020442 Css NA 37.59 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0020442 Css NA 5.896 mg/L PBTK NA 50% Rat Rat -DTXSID0020442 Css NA 29.5 mg/L PBTK NA 95% Rat Rat -DTXSID0020444 Clint NA 6.552 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020444 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020444 Vd NA 5.65 L/kg 1compartment NA NA Human Human -DTXSID0020444 Days.Css NA 129 Days PBTK NA NA Human Human -DTXSID0020444 TK.Half.Life NA 554.1 hours 1compartment NA NA Human Human -DTXSID0020444 Css NA 9.426 mg/L 3compartmentss NA 50% Human Human -DTXSID0020444 Css NA 53 mg/L 3compartmentss NA 95% Human Human -DTXSID0020444 Css NA 8.021 mg/L PBTK NA 50% Human Human -DTXSID0020444 Css NA 44.9 mg/L PBTK NA 95% Human Human -DTXSID0020444 Clint NA 6.552 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020444 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020444 Vd NA 4.337 L/kg 1compartment NA NA Rat Human -DTXSID0020444 Days.Css NA 72 Days PBTK NA NA Rat Human -DTXSID0020444 TK.Half.Life NA 74.28 hours 1compartment NA NA Rat Human -DTXSID0020444 Css NA 5.248 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020444 Css NA 22.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020444 Css NA 4.354 mg/L PBTK NA 50% Rat Human -DTXSID0020444 Css NA 18.39 mg/L PBTK NA 95% Rat Human +DTXSID0020442 TK.Half.Life 0.059 19.39 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID0020442 Css 0.017 0.6098 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID0020442 Css 0.017 3.081 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID0020442 Css 0.017 1.331 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID0020442 Css 0.017 6.734 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID0020446 Clint 12.15 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0020446 Fup 0.1615 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0020446 Vd NA 1.786 L/kg 1compartment NA NA Human Human DTXSID0020446 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0020446 TK.Half.Life NA 5.567 hours 1compartment NA NA Human Human -DTXSID0020446 Css NA 0.3124 mg/L 3compartmentss NA 50% Human Human -DTXSID0020446 Css NA 2.073 mg/L 3compartmentss NA 95% Human Human -DTXSID0020446 Css NA 0.2353 mg/L PBTK NA 50% Human Human -DTXSID0020446 Css NA 1.458 mg/L PBTK NA 95% Human Human +DTXSID0020446 Css NA 0.2662 mg/L 3compartmentss NA 50% Human Human +DTXSID0020446 Css NA 1.632 mg/L 3compartmentss NA 95% Human Human +DTXSID0020446 Css NA 0.2313 mg/L PBTK NA 50% Human Human +DTXSID0020446 Css NA 1.418 mg/L PBTK NA 95% Human Human DTXSID0020446 Clint 2.742 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0020446 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID0020446 Css NA 13.49 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0020446 Css NA 106.8 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0020446 Css NA 2.782 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0020446 Css NA 16.73 mg/L 3compartmentss NA 95% Rat Rat DTXSID0020494 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020494 Fup NA 0.8385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020494 Vd NA 0.7495 L/kg 1compartment NA NA Human Human DTXSID0020494 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0020494 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human -DTXSID0020494 Css NA 0.9696 mg/L 3compartmentss NA 50% Human Human -DTXSID0020494 Css NA 5.966 mg/L 3compartmentss NA 95% Human Human -DTXSID0020494 Css NA 0.7986 mg/L PBTK NA 50% Human Human -DTXSID0020494 Css NA 3.792 mg/L PBTK NA 95% Human Human +DTXSID0020494 Css NA 0.9413 mg/L 3compartmentss NA 50% Human Human +DTXSID0020494 Css NA 5.784 mg/L 3compartmentss NA 95% Human Human +DTXSID0020494 Css NA 0.7784 mg/L PBTK NA 50% Human Human +DTXSID0020494 Css NA 3.716 mg/L PBTK NA 95% Human Human DTXSID0020494 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0020494 Fup 0.9125 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0020494 Vd NA 0.8172 L/kg 1compartment NA NA Rat Rat DTXSID0020494 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID0020494 TK.Half.Life NA 1.976 hours 1compartment NA NA Rat Rat -DTXSID0020494 Css NA 0.2238 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0020494 Css NA 0.805 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0020494 Css NA 0.184 mg/L PBTK NA 50% Rat Rat -DTXSID0020494 Css NA 0.5157 mg/L PBTK NA 95% Rat Rat -DTXSID0020498 Clint NA 527.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020498 Fup NA 0.2812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020498 Vd NA 1.617 L/kg 1compartment NA NA Human Human -DTXSID0020498 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020498 TK.Half.Life NA 1.231 hours 1compartment NA NA Human Human -DTXSID0020498 Css NA 0.003806 mg/L 3compartmentss NA 50% Human Human -DTXSID0020498 Css NA 0.02998 mg/L 3compartmentss NA 95% Human Human -DTXSID0020498 Css NA 0.00287 mg/L PBTK NA 50% Human Human -DTXSID0020498 Css NA 0.02101 mg/L PBTK NA 95% Human Human -DTXSID0020498 Clint NA 527.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020498 Fup NA 0.2812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020498 Vd NA 1.291 L/kg 1compartment NA NA Rat Human -DTXSID0020498 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020498 TK.Half.Life NA 0.4295 hours 1compartment NA NA Rat Human -DTXSID0020498 Css NA 0.002156 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020498 Css NA 0.01294 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020498 Css NA 0.001554 mg/L PBTK NA 50% Rat Human -DTXSID0020498 Css NA 0.008705 mg/L PBTK NA 95% Rat Human +DTXSID0020494 Css NA 0.05104 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0020494 Css NA 0.1786 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0020494 Css NA 0.04338 mg/L PBTK NA 50% Rat Rat +DTXSID0020494 Css NA 0.1188 mg/L PBTK NA 95% Rat Rat DTXSID0020523 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0020523 Fup 0.02723 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0020523 Vd NA 0.3009 L/kg 1compartment NA NA Human Human DTXSID0020523 Days.Css NA 14 Days PBTK NA NA Human Human DTXSID0020523 TK.Half.Life NA 71.5 hours 1compartment NA NA Human Human -DTXSID0020523 Css NA 38.86 mg/L 3compartmentss NA 50% Human Human -DTXSID0020523 Css NA 235.9 mg/L 3compartmentss NA 95% Human Human -DTXSID0020523 Css NA 24.05 mg/L PBTK NA 50% Human Human -DTXSID0020523 Css NA 137.6 mg/L PBTK NA 95% Human Human +DTXSID0020523 Css NA 38.3 mg/L 3compartmentss NA 50% Human Human +DTXSID0020523 Css NA 246.5 mg/L 3compartmentss NA 95% Human Human +DTXSID0020523 Css NA 23.6 mg/L PBTK NA 50% Human Human +DTXSID0020523 Css NA 144.3 mg/L PBTK NA 95% Human Human DTXSID0020523 Clint 3.5 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0020523 Fup 0.031 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0020523 Vd NA 0.307 L/kg 1compartment NA NA Rat Rat DTXSID0020523 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID0020523 TK.Half.Life NA 5.796 hours 1compartment NA NA Rat Rat -DTXSID0020523 Css NA 2.742 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0020523 Css NA 16.92 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0020523 Css NA 1.6 mg/L PBTK NA 50% Rat Rat -DTXSID0020523 Css NA 9.3 mg/L PBTK NA 95% Rat Rat +DTXSID0020523 Css NA 0.616 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0020523 Css NA 3.879 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0020523 Css NA 0.3731 mg/L PBTK NA 50% Rat Rat +DTXSID0020523 Css NA 2.231 mg/L PBTK NA 95% Rat Rat DTXSID0020527 Clint NA 0.06465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020527 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020527 Vd NA 0.8117 L/kg 1compartment NA NA Human Human DTXSID0020527 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0020527 TK.Half.Life NA 4.751 hours 1compartment NA NA Human Human -DTXSID0020527 Css NA 0.7264 mg/L 3compartmentss NA 50% Human Human -DTXSID0020527 Css NA 4.982 mg/L 3compartmentss NA 95% Human Human -DTXSID0020527 Css NA 0.6206 mg/L PBTK NA 50% Human Human -DTXSID0020527 Css NA 3.238 mg/L PBTK NA 95% Human Human +DTXSID0020527 Css NA 0.703 mg/L 3compartmentss NA 50% Human Human +DTXSID0020527 Css NA 4.483 mg/L 3compartmentss NA 95% Human Human +DTXSID0020527 Css NA 0.5975 mg/L PBTK NA 50% Human Human +DTXSID0020527 Css NA 2.923 mg/L PBTK NA 95% Human Human DTXSID0020527 Clint NA 0.06465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020527 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020527 Vd NA 0.8457 L/kg 1compartment NA NA Rat Human DTXSID0020527 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0020527 TK.Half.Life NA 1.773 hours 1compartment NA NA Rat Human -DTXSID0020527 Css NA 0.196 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020527 Css NA 1.263 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020527 Css NA 0.1635 mg/L PBTK NA 50% Rat Human -DTXSID0020527 Css NA 0.7606 mg/L PBTK NA 95% Rat Human +DTXSID0020527 Css NA 0.044 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020527 Css NA 0.2856 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020527 Css NA 0.0381 mg/L PBTK NA 50% Rat Human +DTXSID0020527 Css NA 0.1785 mg/L PBTK NA 95% Rat Human DTXSID0020529 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0020529 Fup 0.09602 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0020529 Vd NA 0.7352 L/kg 1compartment NA NA Human Human DTXSID0020529 Days.Css NA 9 Days PBTK NA NA Human Human DTXSID0020529 TK.Half.Life NA 52.87 hours 1compartment NA NA Human Human -DTXSID0020529 Css NA 10.86 mg/L 3compartmentss NA 50% Human Human -DTXSID0020529 Css NA 50.09 mg/L 3compartmentss NA 95% Human Human -DTXSID0020529 Css NA 6.915 mg/L PBTK NA 50% Human Human -DTXSID0020529 Css NA 29.33 mg/L PBTK NA 95% Human Human +DTXSID0020529 Css NA 10.58 mg/L 3compartmentss NA 50% Human Human +DTXSID0020529 Css NA 47.81 mg/L 3compartmentss NA 95% Human Human +DTXSID0020529 Css NA 6.73 mg/L PBTK NA 50% Human Human +DTXSID0020529 Css NA 28.5 mg/L PBTK NA 95% Human Human DTXSID0020529 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0020529 Fup 0.09602 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0020529 Vd NA 0.598 L/kg 1compartment NA NA Rat Human DTXSID0020529 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID0020529 TK.Half.Life NA 13.95 hours 1compartment NA NA Rat Human -DTXSID0020529 Css NA 3.06 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020529 Css NA 11.76 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020529 Css NA 1.828 mg/L PBTK NA 50% Rat Human -DTXSID0020529 Css NA 6.539 mg/L PBTK NA 95% Rat Human +DTXSID0020529 Css NA 0.682 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020529 Css NA 2.599 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020529 Css NA 0.4222 mg/L PBTK NA 50% Rat Human +DTXSID0020529 Css NA 1.498 mg/L PBTK NA 95% Rat Human DTXSID0020573 Clint 56.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0020573 Fup 4.95e-06 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0020573 Vd NA 0.2523 L/kg 1compartment NA NA Human Human DTXSID0020573 Days.Css NA 18 Days PBTK NA NA Human Human DTXSID0020573 TK.Half.Life NA 87 hours 1compartment NA NA Human Human -DTXSID0020573 Css NA 0.672 mg/L 3compartmentss NA 50% Human Human -DTXSID0020573 Css NA 9.146 mg/L 3compartmentss NA 95% Human Human -DTXSID0020573 Css NA 0.5336 mg/L PBTK NA 50% Human Human -DTXSID0020573 Css NA 6.079 mg/L PBTK NA 95% Human Human +DTXSID0020573 Css NA 0.6497 mg/L 3compartmentss NA 50% Human Human +DTXSID0020573 Css NA 8.85 mg/L 3compartmentss NA 95% Human Human +DTXSID0020573 Css NA 0.5099 mg/L PBTK NA 50% Human Human +DTXSID0020573 Css NA 5.874 mg/L PBTK NA 95% Human Human DTXSID0020573 Clint 56.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0020573 Fup 4.95e-06 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0020573 Vd NA 0.2151 L/kg 1compartment NA NA Rat Human DTXSID0020573 Days.Css NA 9 Days PBTK NA NA Rat Human DTXSID0020573 TK.Half.Life NA 51.77 hours 1compartment NA NA Rat Human -DTXSID0020573 Css NA 0.3601 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020573 Css NA 4.505 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020573 Css NA 0.2746 mg/L PBTK NA 50% Rat Human -DTXSID0020573 Css NA 2.85 mg/L PBTK NA 95% Rat Human -DTXSID0020575 Clint NA 30.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020575 Fup NA 0.2026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020575 Vd NA 2.397 L/kg 1compartment NA NA Human Human -DTXSID0020575 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020575 TK.Half.Life NA 4.77 hours 1compartment NA NA Human Human -DTXSID0020575 Css NA 0.151 mg/L 3compartmentss NA 50% Human Human -DTXSID0020575 Css NA 0.974 mg/L 3compartmentss NA 95% Human Human -DTXSID0020575 Css NA 0.11 mg/L PBTK NA 50% Human Human -DTXSID0020575 Css NA 0.6713 mg/L PBTK NA 95% Human Human -DTXSID0020575 Clint NA 30.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020575 Fup NA 0.2026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020575 Vd NA 1.831 L/kg 1compartment NA NA Rat Human -DTXSID0020575 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020575 TK.Half.Life NA 1.418 hours 1compartment NA NA Rat Human -DTXSID0020575 Css NA 0.08282 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020575 Css NA 0.4189 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020575 Css NA 0.05783 mg/L PBTK NA 50% Rat Human -DTXSID0020575 Css NA 0.2793 mg/L PBTK NA 95% Rat Human -DTXSID0020577 Clint NA 0.5479 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020577 Fup NA 0.5731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020577 Vd NA 0.9657 L/kg 1compartment NA NA Human Human +DTXSID0020573 Css NA 0.08038 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020573 Css NA 1.011 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020573 Css NA 0.06338 mg/L PBTK NA 50% Rat Human +DTXSID0020573 Css NA 0.6487 mg/L PBTK NA 95% Rat Human +DTXSID0020577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020577 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020577 Vd NA 0.6271 L/kg 1compartment NA NA Human Human DTXSID0020577 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020577 TK.Half.Life NA 6.006 hours 1compartment NA NA Human Human -DTXSID0020577 Css NA 0.6416 mg/L 3compartmentss NA 50% Human Human -DTXSID0020577 Css NA 4.509 mg/L 3compartmentss NA 95% Human Human -DTXSID0020577 Css NA 0.5368 mg/L PBTK NA 50% Human Human -DTXSID0020577 Css NA 2.874 mg/L PBTK NA 95% Human Human -DTXSID0020577 Clint NA 0.5479 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020577 Fup NA 0.5731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020577 Vd NA 0.9139 L/kg 1compartment NA NA Rat Human +DTXSID0020577 TK.Half.Life NA 0.7254 hours 1compartment NA NA Human Human +DTXSID0020577 Css NA 0.05116 mg/L 3compartmentss NA 50% Human Human +DTXSID0020577 Css NA 0.4192 mg/L 3compartmentss NA 95% Human Human +DTXSID0020577 Css NA 0.03767 mg/L PBTK NA 50% Human Human +DTXSID0020577 Css NA 0.2822 mg/L PBTK NA 95% Human Human +DTXSID0020577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020577 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020577 Vd NA 0.6158 L/kg 1compartment NA NA Rat Human DTXSID0020577 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020577 TK.Half.Life NA 2.474 hours 1compartment NA NA Rat Human -DTXSID0020577 Css NA 0.2299 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020577 Css NA 1.546 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020577 Css NA 0.1849 mg/L PBTK NA 50% Rat Human -DTXSID0020577 Css NA 0.9202 mg/L PBTK NA 95% Rat Human +DTXSID0020577 TK.Half.Life NA 0.3689 hours 1compartment NA NA Rat Human +DTXSID0020577 Css NA 0.00642 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020577 Css NA 0.03843 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020577 Css NA 0.004722 mg/L PBTK NA 50% Rat Human +DTXSID0020577 Css NA 0.02518 mg/L PBTK NA 95% Rat Human DTXSID0020602 Clint NA 0.005107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020602 Fup NA 0.9419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020602 Vd NA 0.7516 L/kg 1compartment NA NA Human Human +DTXSID0020602 Vd NA 0.7656 L/kg 1compartment NA NA Human Human DTXSID0020602 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020602 TK.Half.Life NA 5.123 hours 1compartment NA NA Human Human -DTXSID0020602 Css NA 0.8516 mg/L 3compartmentss NA 50% Human Human -DTXSID0020602 Css NA 3.201 mg/L 3compartmentss NA 95% Human Human -DTXSID0020602 Css NA 0.711 mg/L PBTK NA 50% Human Human -DTXSID0020602 Css NA 2.207 mg/L PBTK NA 95% Human Human +DTXSID0020602 TK.Half.Life NA 5.219 hours 1compartment NA NA Human Human +DTXSID0020602 Css NA 0.7179 mg/L 3compartmentss NA 50% Human Human +DTXSID0020602 Css NA 2.682 mg/L 3compartmentss NA 95% Human Human +DTXSID0020602 Css NA 0.6018 mg/L PBTK NA 50% Human Human +DTXSID0020602 Css NA 1.886 mg/L PBTK NA 95% Human Human DTXSID0020602 Clint NA 0.005107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020602 Fup NA 0.9419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020602 Vd NA 0.7878 L/kg 1compartment NA NA Rat Human +DTXSID0020602 Vd NA 0.7998 L/kg 1compartment NA NA Rat Human DTXSID0020602 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020602 TK.Half.Life NA 1.837 hours 1compartment NA NA Rat Human -DTXSID0020602 Css NA 0.22 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020602 Css NA 0.7299 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020602 Css NA 0.1793 mg/L PBTK NA 50% Rat Human -DTXSID0020602 Css NA 0.4708 mg/L PBTK NA 95% Rat Human +DTXSID0020602 TK.Half.Life NA 1.865 hours 1compartment NA NA Rat Human +DTXSID0020602 Css NA 0.01316 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020602 Css NA 0.07109 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020602 Css NA 0.01062 mg/L PBTK NA 50% Rat Human +DTXSID0020602 Css NA 0.05084 mg/L PBTK NA 95% Rat Human DTXSID0020604 Clint 136 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0020604 Fup NA 0.8324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020604 Vd NA 0.9648 L/kg 1compartment NA NA Human Human +DTXSID0020604 Fup 0.63 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020604 Vd NA 0.8174 L/kg 1compartment NA NA Human Human DTXSID0020604 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020604 TK.Half.Life NA 0.5719 hours 1compartment NA NA Human Human -DTXSID0020604 Css NA 0.004641 mg/L 3compartmentss NA 50% Human Human -DTXSID0020604 Css NA 0.07548 mg/L 3compartmentss NA 95% Human Human -DTXSID0020604 Css NA 0.003917 mg/L PBTK NA 50% Human Human -DTXSID0020604 Css NA 0.05654 mg/L PBTK NA 95% Human Human +DTXSID0020604 TK.Half.Life NA 0.5462 hours 1compartment NA NA Human Human +DTXSID0020604 Css NA 0.00427 mg/L 3compartmentss NA 50% Human Human +DTXSID0020604 Css NA 0.09219 mg/L 3compartmentss NA 95% Human Human +DTXSID0020604 Css NA 0.003448 mg/L PBTK NA 50% Human Human +DTXSID0020604 Css NA 0.06535 mg/L PBTK NA 95% Human Human DTXSID0020604 Clint 136 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0020604 Fup NA 0.8324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020604 Vd NA 0.9516 L/kg 1compartment NA NA Rat Human +DTXSID0020604 Fup 0.63 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020604 Vd NA 0.8043 L/kg 1compartment NA NA Rat Human DTXSID0020604 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020604 TK.Half.Life NA 0.2489 hours 1compartment NA NA Rat Human -DTXSID0020604 Css NA 0.00256 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020604 Css NA 0.03459 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020604 Css NA 0.002142 mg/L PBTK NA 50% Rat Human -DTXSID0020604 Css NA 0.02441 mg/L PBTK NA 95% Rat Human +DTXSID0020604 TK.Half.Life NA 0.2395 hours 1compartment NA NA Rat Human +DTXSID0020604 Css NA 0.0005797 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020604 Css NA 0.009838 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020604 Css NA 0.0004808 mg/L PBTK NA 50% Rat Human +DTXSID0020604 Css NA 0.006719 mg/L PBTK NA 95% Rat Human DTXSID0020606 Clint 13.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0020606 Fup 0.03861 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID0020606 Vd NA 12.32 L/kg 1compartment NA NA Human Human -DTXSID0020606 Days.Css NA 134 Days PBTK NA NA Human Human -DTXSID0020606 TK.Half.Life NA 581.5 hours 1compartment NA NA Human Human -DTXSID0020606 Css NA 2.773 mg/L 3compartmentss NA 50% Human Human -DTXSID0020606 Css NA 16.33 mg/L 3compartmentss NA 95% Human Human -DTXSID0020606 Css NA 3.85 mg/L PBTK NA 50% Human Human -DTXSID0020606 Css NA 21.44 mg/L PBTK NA 95% Human Human +DTXSID0020606 Vd NA 628.6 L/kg 1compartment NA NA Human Human +DTXSID0020606 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID0020606 TK.Half.Life NA 29420 hours 1compartment NA NA Human Human +DTXSID0020606 Css NA 0.02111 mg/L 3compartmentss NA 50% Human Human +DTXSID0020606 Css NA 0.1516 mg/L 3compartmentss NA 95% Human Human +DTXSID0020606 Css NA 2.062 mg/L PBTK NA 50% Human Human +DTXSID0020606 Css NA 13 mg/L PBTK NA 95% Human Human DTXSID0020606 Clint 13.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0020606 Fup 0.03861 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID0020606 Vd NA 9.784 L/kg 1compartment NA NA Rat Human -DTXSID0020606 Days.Css NA 79 Days PBTK NA NA Rat Human -DTXSID0020606 TK.Half.Life NA 79.09 hours 1compartment NA NA Rat Human -DTXSID0020606 Css NA 1.499 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020606 Css NA 6.395 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020606 Css NA 2.098 mg/L PBTK NA 50% Rat Human -DTXSID0020606 Css NA 9.234 mg/L PBTK NA 95% Rat Human +DTXSID0020606 Vd NA 570.6 L/kg 1compartment NA NA Rat Human +DTXSID0020606 Days.Css NA 5232 Days PBTK NA NA Rat Human +DTXSID0020606 TK.Half.Life NA 4516 hours 1compartment NA NA Rat Human +DTXSID0020606 Css NA 0.0002066 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020606 Css NA 0.001285 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020606 Css NA 0.02177 mg/L PBTK NA 50% Rat Human +DTXSID0020606 Css NA 0.1316 mg/L PBTK NA 95% Rat Human +DTXSID00206409 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00206409 Fup 0.00938 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00206409 Vd NA 2.134 L/kg 1compartment NA NA Human Human +DTXSID00206409 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID00206409 TK.Half.Life NA 35.42 hours 1compartment NA NA Human Human +DTXSID00206409 Css NA 2.474 mg/L 3compartmentss NA 50% Human Human +DTXSID00206409 Css NA 20.62 mg/L 3compartmentss NA 95% Human Human +DTXSID00206409 Css NA 1.6 mg/L PBTK NA 50% Human Human +DTXSID00206409 Css NA 12.71 mg/L PBTK NA 95% Human Human +DTXSID00206409 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00206409 Fup 0.00938 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00206409 Vd NA 1.583 L/kg 1compartment NA NA Rat Human +DTXSID00206409 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID00206409 TK.Half.Life NA 10.65 hours 1compartment NA NA Rat Human +DTXSID00206409 Css NA 0.324 mg/L 3compartmentss NA 50% Rat Human +DTXSID00206409 Css NA 2.198 mg/L 3compartmentss NA 95% Rat Human +DTXSID00206409 Css NA 0.2034 mg/L PBTK NA 50% Rat Human +DTXSID00206409 Css NA 1.305 mg/L PBTK NA 95% Rat Human DTXSID0020650 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020650 Fup NA 0.2702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0020650 Vd NA 0.4102 L/kg 1compartment NA NA Human Human DTXSID0020650 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID0020650 TK.Half.Life NA 9.821 hours 1compartment NA NA Human Human -DTXSID0020650 Css NA 2.843 mg/L 3compartmentss NA 50% Human Human -DTXSID0020650 Css NA 11.02 mg/L 3compartmentss NA 95% Human Human -DTXSID0020650 Css NA 1.952 mg/L PBTK NA 50% Human Human -DTXSID0020650 Css NA 6.851 mg/L PBTK NA 95% Human Human +DTXSID0020650 Css NA 1.526 mg/L 3compartmentss NA 50% Human Human +DTXSID0020650 Css NA 6.251 mg/L 3compartmentss NA 95% Human Human +DTXSID0020650 Css NA 1.052 mg/L PBTK NA 50% Human Human +DTXSID0020650 Css NA 3.896 mg/L PBTK NA 95% Human Human DTXSID0020650 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020650 Fup NA 0.2702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0020650 Vd NA 0.4156 L/kg 1compartment NA NA Rat Human DTXSID0020650 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0020650 TK.Half.Life NA 3.391 hours 1compartment NA NA Rat Human -DTXSID0020650 Css NA 0.7952 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020650 Css NA 2.54 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020650 Css NA 0.5178 mg/L PBTK NA 50% Rat Human -DTXSID0020650 Css NA 1.471 mg/L PBTK NA 95% Rat Human +DTXSID0020650 Css NA 0.00823 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020650 Css NA 0.03547 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020650 Css NA 0.00541 mg/L PBTK NA 50% Rat Human +DTXSID0020650 Css NA 0.02106 mg/L PBTK NA 95% Rat Human DTXSID0020652 Clint 52.18 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0020652 Fup 0.03 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human -DTXSID0020652 Vd NA 0.6001 L/kg 1compartment NA NA Human Human +DTXSID0020652 Vd NA 0.2872 L/kg 1compartment NA NA Human Human DTXSID0020652 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020652 TK.Half.Life NA 1.984 hours 1compartment NA NA Human Human -DTXSID0020652 Css NA 0.4618 mg/L 3compartmentss NA 50% Human Human -DTXSID0020652 Css NA 4.393 mg/L 3compartmentss NA 95% Human Human -DTXSID0020652 Css NA 0.2642 mg/L PBTK NA 50% Human Human -DTXSID0020652 Css NA 2.51 mg/L PBTK NA 95% Human Human +DTXSID0020652 TK.Half.Life NA 0.9749 hours 1compartment NA NA Human Human +DTXSID0020652 Css NA 0.4852 mg/L 3compartmentss NA 50% Human Human +DTXSID0020652 Css NA 4.834 mg/L 3compartmentss NA 95% Human Human +DTXSID0020652 Css NA 0.2667 mg/L PBTK NA 50% Human Human +DTXSID0020652 Css NA 2.658 mg/L PBTK NA 95% Human Human DTXSID0020652 Clint 52.18 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID0020652 Fup 0.03 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human -DTXSID0020652 Vd NA 0.4802 L/kg 1compartment NA NA Rat Human +DTXSID0020652 Vd 0.093 0.2609 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID0020652 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020652 TK.Half.Life NA 0.9486 hours 1compartment NA NA Rat Human -DTXSID0020652 Css NA 0.2687 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020652 Css NA 2.055 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020652 Css NA 0.143 mg/L PBTK NA 50% Rat Human -DTXSID0020652 Css NA 1.102 mg/L PBTK NA 95% Rat Human +DTXSID0020652 TK.Half.Life 0.055 0.5445 hours 1compartment National Toxicology Program NA Rat Human +DTXSID0020652 Css 0.035 0.06165 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID0020652 Css 0.035 0.4979 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID0020652 Css 0.035 0.03512 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID0020652 Css 0.035 0.2835 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID0020654 Clint 823 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID0020654 Fup 0.192 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID0020654 Vd NA 3.043 L/kg 1compartment NA NA Human Human +DTXSID0020654 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0020654 TK.Half.Life NA 2.995 hours 1compartment NA NA Human Human +DTXSID0020654 Css NA 0.01948 mg/L 3compartmentss NA 50% Human Human +DTXSID0020654 Css NA 0.1382 mg/L 3compartmentss NA 95% Human Human +DTXSID0020654 Css NA 0.01378 mg/L PBTK NA 50% Human Human +DTXSID0020654 Css NA 0.09441 mg/L PBTK NA 95% Human Human +DTXSID0020654 Clint 823 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID0020654 Fup 0.192 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID0020654 Vd NA 2.29 L/kg 1compartment NA NA Rat Human +DTXSID0020654 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0020654 TK.Half.Life NA 0.8843 hours 1compartment NA NA Rat Human +DTXSID0020654 Css NA 0.002588 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020654 Css NA 0.01535 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020654 Css NA 0.001823 mg/L PBTK NA 50% Rat Human +DTXSID0020654 Css NA 0.01063 mg/L PBTK NA 95% Rat Human DTXSID0020656 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID0020656 Fup 0.24 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID0020656 Vd NA 0.2902 L/kg 1compartment NA NA Human Human DTXSID0020656 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0020656 TK.Half.Life NA 7.824 hours 1compartment NA NA Human Human -DTXSID0020656 Css NA 3.409 mg/L 3compartmentss NA 50% Human Human -DTXSID0020656 Css NA 12.6 mg/L 3compartmentss NA 95% Human Human -DTXSID0020656 Css NA 2.204 mg/L PBTK NA 50% Human Human -DTXSID0020656 Css NA 7.509 mg/L PBTK NA 95% Human Human +DTXSID0020656 Css NA 3.296 mg/L 3compartmentss NA 50% Human Human +DTXSID0020656 Css NA 12.13 mg/L 3compartmentss NA 95% Human Human +DTXSID0020656 Css NA 2.117 mg/L PBTK NA 50% Human Human +DTXSID0020656 Css NA 7.255 mg/L PBTK NA 95% Human Human DTXSID0020656 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0020656 Fup 0.8015 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0020656 Vd NA 0.5263 L/kg 1compartment NA NA Rat Rat DTXSID0020656 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID0020656 TK.Half.Life NA 1.448 hours 1compartment NA NA Rat Rat -DTXSID0020656 Css NA 0.277 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0020656 Css NA 1.544 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0020656 Css NA 0.2021 mg/L PBTK NA 50% Rat Rat -DTXSID0020656 Css NA 0.8999 mg/L PBTK NA 95% Rat Rat -DTXSID0020733 Clint NA 25.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020733 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020733 Vd NA 0.7653 L/kg 1compartment NA NA Human Human +DTXSID0020656 Css NA 0.06172 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0020656 Css NA 0.3455 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0020656 Css NA 0.04674 mg/L PBTK NA 50% Rat Rat +DTXSID0020656 Css NA 0.2086 mg/L PBTK NA 95% Rat Rat +DTXSID0020733 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020733 Fup 0.819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020733 Vd NA 0.6807 L/kg 1compartment NA NA Human Human DTXSID0020733 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020733 TK.Half.Life NA 0.5227 hours 1compartment NA NA Human Human -DTXSID0020733 Css NA 0.0202 mg/L 3compartmentss NA 50% Human Human -DTXSID0020733 Css NA 0.2555 mg/L 3compartmentss NA 95% Human Human -DTXSID0020733 Css NA 0.01666 mg/L PBTK NA 50% Human Human -DTXSID0020733 Css NA 0.1896 mg/L PBTK NA 95% Human Human -DTXSID0020733 Clint NA 25.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020733 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020733 Vd NA 0.8055 L/kg 1compartment NA NA Rat Human +DTXSID0020733 TK.Half.Life NA 5.377 hours 1compartment NA NA Human Human +DTXSID0020733 Css NA 0.8562 mg/L 3compartmentss NA 50% Human Human +DTXSID0020733 Css NA 5.137 mg/L 3compartmentss NA 95% Human Human +DTXSID0020733 Css NA 0.6972 mg/L PBTK NA 50% Human Human +DTXSID0020733 Css NA 3.361 mg/L PBTK NA 95% Human Human +DTXSID0020733 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020733 Fup 0.819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020733 Vd NA 0.716 L/kg 1compartment NA NA Rat Human DTXSID0020733 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020733 TK.Half.Life NA 0.2582 hours 1compartment NA NA Rat Human -DTXSID0020733 Css NA 0.01022 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020733 Css NA 0.1018 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020733 Css NA 0.00831 mg/L PBTK NA 50% Rat Human -DTXSID0020733 Css NA 0.07122 mg/L PBTK NA 95% Rat Human -DTXSID0020737 Clint NA 2.331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020737 Fup NA 0.2627 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020737 Vd NA 1.432 L/kg 1compartment NA NA Human Human +DTXSID0020733 TK.Half.Life NA 1.928 hours 1compartment NA NA Rat Human +DTXSID0020733 Css NA 0.02218 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020733 Css NA 0.1535 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020733 Css NA 0.01747 mg/L PBTK NA 50% Rat Human +DTXSID0020733 Css NA 0.09833 mg/L PBTK NA 95% Rat Human +DTXSID0020737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020737 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020737 Vd NA 1.369 L/kg 1compartment NA NA Human Human DTXSID0020737 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020737 TK.Half.Life NA 9.268 hours 1compartment NA NA Human Human -DTXSID0020737 Css NA 0.6997 mg/L 3compartmentss NA 50% Human Human -DTXSID0020737 Css NA 3.324 mg/L 3compartmentss NA 95% Human Human -DTXSID0020737 Css NA 0.5213 mg/L PBTK NA 50% Human Human -DTXSID0020737 Css NA 2.229 mg/L PBTK NA 95% Human Human -DTXSID0020737 Clint NA 2.331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020737 Fup NA 0.2627 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020737 Vd NA 1.154 L/kg 1compartment NA NA Rat Human +DTXSID0020737 TK.Half.Life NA 2.125 hours 1compartment NA NA Human Human +DTXSID0020737 Css NA 0.09505 mg/L 3compartmentss NA 50% Human Human +DTXSID0020737 Css NA 0.6903 mg/L 3compartmentss NA 95% Human Human +DTXSID0020737 Css NA 0.07012 mg/L PBTK NA 50% Human Human +DTXSID0020737 Css NA 0.4714 mg/L PBTK NA 95% Human Human +DTXSID0020737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020737 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020737 Vd NA 1.102 L/kg 1compartment NA NA Rat Human DTXSID0020737 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020737 TK.Half.Life NA 3.555 hours 1compartment NA NA Rat Human -DTXSID0020737 Css NA 0.3204 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020737 Css NA 1.148 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020737 Css NA 0.23 mg/L PBTK NA 50% Rat Human -DTXSID0020737 Css NA 0.7151 mg/L PBTK NA 95% Rat Human +DTXSID0020737 TK.Half.Life NA 0.8618 hours 1compartment NA NA Rat Human +DTXSID0020737 Css NA 0.01215 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020737 Css NA 0.06369 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020737 Css NA 0.008824 mg/L PBTK NA 50% Rat Human +DTXSID0020737 Css NA 0.0434 mg/L PBTK NA 95% Rat Human DTXSID0020785 Clint 11 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID0020785 Fup 0.96 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID0020785 Vd NA 3.568 L/kg 1compartment NA NA Human Human +DTXSID0020785 Vd NA 3.816 L/kg 1compartment NA NA Human Human DTXSID0020785 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020785 TK.Half.Life NA 2.605 hours 1compartment NA NA Human Human -DTXSID0020785 Css NA 0.03427 mg/L 3compartmentss NA 50% Human Human -DTXSID0020785 Css NA 0.3467 mg/L 3compartmentss NA 95% Human Human -DTXSID0020785 Css NA 0.04148 mg/L PBTK NA 50% Human Human -DTXSID0020785 Css NA 0.3156 mg/L PBTK NA 95% Human Human +DTXSID0020785 TK.Half.Life NA 2.863 hours 1compartment NA NA Human Human +DTXSID0020785 Css NA 0.03226 mg/L 3compartmentss NA 50% Human Human +DTXSID0020785 Css NA 0.3417 mg/L 3compartmentss NA 95% Human Human +DTXSID0020785 Css NA 0.04003 mg/L PBTK NA 50% Human Human +DTXSID0020785 Css NA 0.3215 mg/L PBTK NA 95% Human Human DTXSID0020785 Clint 11 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID0020785 Fup 0.96 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human -DTXSID0020785 Vd NA 3.532 L/kg 1compartment NA NA Rat Human +DTXSID0020785 Vd NA 3.742 L/kg 1compartment NA NA Rat Human DTXSID0020785 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020785 TK.Half.Life NA 1.293 hours 1compartment NA NA Rat Human -DTXSID0020785 Css NA 0.01647 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020785 Css NA 0.144 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020785 Css NA 0.02047 mg/L PBTK NA 50% Rat Human -DTXSID0020785 Css NA 0.1205 mg/L PBTK NA 95% Rat Human -DTXSID0020789 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020789 Fup NA 0.7013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020789 Vd NA 0.97 L/kg 1compartment NA NA Human Human -DTXSID0020789 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020789 TK.Half.Life NA 9.189 hours 1compartment NA NA Human Human -DTXSID0020789 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human -DTXSID0020789 Css NA 6.815 mg/L 3compartmentss NA 95% Human Human -DTXSID0020789 Css NA 0.89 mg/L PBTK NA 50% Human Human -DTXSID0020789 Css NA 4.445 mg/L PBTK NA 95% Human Human -DTXSID0020789 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020789 Fup NA 0.7013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020789 Vd NA 0.9335 L/kg 1compartment NA NA Rat Human -DTXSID0020789 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020789 TK.Half.Life NA 2.953 hours 1compartment NA NA Rat Human -DTXSID0020789 Css NA 0.271 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020789 Css NA 1.867 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020789 Css NA 0.2247 mg/L PBTK NA 50% Rat Human -DTXSID0020789 Css NA 1.117 mg/L PBTK NA 95% Rat Human -DTXSID0020810 Clint NA 0.08016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0020785 TK.Half.Life NA 1.373 hours 1compartment NA NA Rat Human +DTXSID0020785 Css NA 0.003621 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020785 Css NA 0.03336 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020785 Css NA 0.004818 mg/L PBTK NA 50% Rat Human +DTXSID0020785 Css NA 0.02962 mg/L PBTK NA 95% Rat Human +DTXSID0020810 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0020810 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0020810 Vd NA 0.8844 L/kg 1compartment NA NA Human Human DTXSID0020810 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020810 TK.Half.Life NA 5.986 hours 1compartment NA NA Human Human -DTXSID0020810 Css NA 0.1205 mg/L 3compartmentss NA 50% Human Human -DTXSID0020810 Css NA 0.8611 mg/L 3compartmentss NA 95% Human Human -DTXSID0020810 Css NA 0.1308 mg/L PBTK NA 50% Human Human -DTXSID0020810 Css NA 0.6183 mg/L PBTK NA 95% Human Human -DTXSID0020810 Clint NA 0.08016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0020810 TK.Half.Life NA 6.776 hours 1compartment NA NA Human Human +DTXSID0020810 Css NA 0.6424 mg/L 3compartmentss NA 50% Human Human +DTXSID0020810 Css NA 3.016 mg/L 3compartmentss NA 95% Human Human +DTXSID0020810 Css NA 0.7708 mg/L PBTK NA 50% Human Human +DTXSID0020810 Css NA 3.619 mg/L PBTK NA 95% Human Human +DTXSID0020810 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0020810 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0020810 Vd NA 0.895 L/kg 1compartment NA NA Rat Human DTXSID0020810 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020810 TK.Half.Life NA 2.185 hours 1compartment NA NA Rat Human -DTXSID0020810 Css NA 0.1714 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020810 Css NA 1.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020810 Css NA 0.1838 mg/L PBTK NA 50% Rat Human -DTXSID0020810 Css NA 0.8199 mg/L PBTK NA 95% Rat Human -DTXSID0020814 Clint NA 17.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020814 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020814 Vd NA 2.636 L/kg 1compartment NA NA Human Human -DTXSID0020814 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID0020814 TK.Half.Life NA 35.04 hours 1compartment NA NA Human Human -DTXSID0020814 Css NA 1.829 mg/L 3compartmentss NA 50% Human Human -DTXSID0020814 Css NA 12.7 mg/L 3compartmentss NA 95% Human Human -DTXSID0020814 Css NA 1.229 mg/L PBTK NA 50% Human Human -DTXSID0020814 Css NA 8.13 mg/L PBTK NA 95% Human Human -DTXSID0020814 Clint NA 17.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020814 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020814 Vd NA 1.972 L/kg 1compartment NA NA Rat Human -DTXSID0020814 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0020814 TK.Half.Life NA 7.905 hours 1compartment NA NA Rat Human -DTXSID0020814 Css NA 1.025 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020814 Css NA 5.341 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020814 Css NA 0.6514 mg/L PBTK NA 50% Rat Human -DTXSID0020814 Css NA 3.269 mg/L PBTK NA 95% Rat Human -DTXSID0020818 Clint NA 7.554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020818 Fup NA 0.2704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020818 Vd NA 3.278 L/kg 1compartment NA NA Human Human +DTXSID0020810 TK.Half.Life NA 2.325 hours 1compartment NA NA Rat Human +DTXSID0020810 Css NA 0.0368 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020810 Css NA 0.1615 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020810 Css NA 0.04574 mg/L PBTK NA 50% Rat Human +DTXSID0020810 Css NA 0.2008 mg/L PBTK NA 95% Rat Human +DTXSID0020814 Clint 10.2 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID0020814 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020814 Vd NA 2.778 L/kg 1compartment NA NA Human Human +DTXSID0020814 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID0020814 TK.Half.Life NA 94.95 hours 1compartment NA NA Human Human +DTXSID0020814 Css NA 4.668 mg/L 3compartmentss NA 50% Human Human +DTXSID0020814 Css NA 32.32 mg/L 3compartmentss NA 95% Human Human +DTXSID0020814 Css NA 3.136 mg/L PBTK NA 50% Human Human +DTXSID0020814 Css NA 20.81 mg/L PBTK NA 95% Human Human +DTXSID0020814 Clint 10.2 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human +DTXSID0020814 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020814 Vd NA 2.077 L/kg 1compartment NA NA Rat Human +DTXSID0020814 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0020814 TK.Half.Life NA 1.969 hours 1compartment NA NA Rat Human +DTXSID0020814 Css NA 0.04044 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020814 Css NA 0.2552 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020814 Css NA 0.02674 mg/L PBTK NA 50% Rat Human +DTXSID0020814 Css NA 0.1649 mg/L PBTK NA 95% Rat Human +DTXSID0020818 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020818 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020818 Vd NA 1.463 L/kg 1compartment NA NA Human Human DTXSID0020818 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020818 TK.Half.Life NA 8.032 hours 1compartment NA NA Human Human -DTXSID0020818 Css NA 0.1765 mg/L 3compartmentss NA 50% Human Human -DTXSID0020818 Css NA 1.121 mg/L 3compartmentss NA 95% Human Human -DTXSID0020818 Css NA 0.1776 mg/L PBTK NA 50% Human Human -DTXSID0020818 Css NA 0.9633 mg/L PBTK NA 95% Human Human -DTXSID0020818 Clint NA 7.554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020818 Fup NA 0.2704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020818 Vd NA 3.095 L/kg 1compartment NA NA Rat Human +DTXSID0020818 TK.Half.Life NA 2.758 hours 1compartment NA NA Human Human +DTXSID0020818 Css NA 0.1343 mg/L 3compartmentss NA 50% Human Human +DTXSID0020818 Css NA 0.9802 mg/L 3compartmentss NA 95% Human Human +DTXSID0020818 Css NA 0.1171 mg/L PBTK NA 50% Human Human +DTXSID0020818 Css NA 0.6966 mg/L PBTK NA 95% Human Human +DTXSID0020818 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020818 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020818 Vd NA 1.473 L/kg 1compartment NA NA Rat Human DTXSID0020818 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020818 TK.Half.Life NA 3.796 hours 1compartment NA NA Rat Human -DTXSID0020818 Css NA 0.08934 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020818 Css NA 0.4352 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020818 Css NA 0.08827 mg/L PBTK NA 50% Rat Human -DTXSID0020818 Css NA 0.3531 mg/L PBTK NA 95% Rat Human -DTXSID0020941 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020941 Fup NA 0.2751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0020941 Vd NA 0.3843 L/kg 1compartment NA NA Human Human -DTXSID0020941 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0020941 TK.Half.Life NA 9.039 hours 1compartment NA NA Human Human -DTXSID0020941 Css NA 2.842 mg/L 3compartmentss NA 50% Human Human -DTXSID0020941 Css NA 10.97 mg/L 3compartmentss NA 95% Human Human -DTXSID0020941 Css NA 1.918 mg/L PBTK NA 50% Human Human -DTXSID0020941 Css NA 6.707 mg/L PBTK NA 95% Human Human -DTXSID0020941 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020941 Fup NA 0.2751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0020941 Vd NA 0.3959 L/kg 1compartment NA NA Rat Human -DTXSID0020941 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0020941 TK.Half.Life NA 3.172 hours 1compartment NA NA Rat Human -DTXSID0020941 Css NA 0.7834 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020941 Css NA 2.561 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020941 Css NA 0.5034 mg/L PBTK NA 50% Rat Human -DTXSID0020941 Css NA 1.472 mg/L PBTK NA 95% Rat Human +DTXSID0020818 TK.Half.Life NA 1.571 hours 1compartment NA NA Rat Human +DTXSID0020818 Css NA 0.01538 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020818 Css NA 0.08695 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020818 Css NA 0.01336 mg/L PBTK NA 50% Rat Human +DTXSID0020818 Css NA 0.06004 mg/L PBTK NA 95% Rat Human +DTXSID0020862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020862 Fup 0.0216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0020862 Vd NA 3.701 L/kg 1compartment NA NA Human Human +DTXSID0020862 Days.Css NA 19 Days PBTK NA NA Human Human +DTXSID0020862 TK.Half.Life NA 111.4 hours 1compartment NA NA Human Human +DTXSID0020862 Css NA 3.24 mg/L 3compartmentss NA 50% Human Human +DTXSID0020862 Css NA 18.9 mg/L 3compartmentss NA 95% Human Human +DTXSID0020862 Css NA 2.358 mg/L PBTK NA 50% Human Human +DTXSID0020862 Css NA 13.64 mg/L PBTK NA 95% Human Human +DTXSID0020862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020862 Fup 0.0216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0020862 Vd NA 2.792 L/kg 1compartment NA NA Rat Human +DTXSID0020862 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID0020862 TK.Half.Life NA 14.92 hours 1compartment NA NA Rat Human +DTXSID0020862 Css NA 0.4234 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020862 Css NA 2.039 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020862 Css NA 0.3057 mg/L PBTK NA 50% Rat Human +DTXSID0020862 Css NA 1.482 mg/L PBTK NA 95% Rat Human +DTXSID00208827 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00208827 Fup 0.47 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00208827 Vd NA 0.336 L/kg 1compartment NA NA Human Human +DTXSID00208827 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00208827 TK.Half.Life NA 4.624 hours 1compartment NA NA Human Human +DTXSID00208827 Css NA 0.9088 mg/L 3compartmentss NA 50% Human Human +DTXSID00208827 Css NA 4.323 mg/L 3compartmentss NA 95% Human Human +DTXSID00208827 Css NA 0.6226 mg/L PBTK NA 50% Human Human +DTXSID00208827 Css NA 2.641 mg/L PBTK NA 95% Human Human +DTXSID00208827 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00208827 Fup 0.47 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00208827 Vd NA 0.3535 L/kg 1compartment NA NA Rat Human +DTXSID00208827 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00208827 TK.Half.Life NA 1.658 hours 1compartment NA NA Rat Human +DTXSID00208827 Css NA 0.004986 mg/L 3compartmentss NA 50% Rat Human +DTXSID00208827 Css NA 0.02465 mg/L 3compartmentss NA 95% Rat Human +DTXSID00208827 Css NA 0.003221 mg/L PBTK NA 50% Rat Human +DTXSID00208827 Css NA 0.01432 mg/L PBTK NA 95% Rat Human DTXSID0020943 Clint 12.03 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0020943 Fup 0.3359 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0020943 Vd NA 0.9654 L/kg 1compartment NA NA Human Human DTXSID0020943 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0020943 TK.Half.Life NA 1.556 hours 1compartment NA NA Human Human -DTXSID0020943 Css NA 0.1116 mg/L 3compartmentss NA 50% Human Human -DTXSID0020943 Css NA 0.7718 mg/L 3compartmentss NA 95% Human Human -DTXSID0020943 Css NA 0.08374 mg/L PBTK NA 50% Human Human -DTXSID0020943 Css NA 0.5203 mg/L PBTK NA 95% Human Human +DTXSID0020943 Css NA 0.1068 mg/L 3compartmentss NA 50% Human Human +DTXSID0020943 Css NA 0.7506 mg/L 3compartmentss NA 95% Human Human +DTXSID0020943 Css NA 0.08044 mg/L PBTK NA 50% Human Human +DTXSID0020943 Css NA 0.5147 mg/L PBTK NA 95% Human Human DTXSID0020943 Clint 12.03 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0020943 Fup 0.3359 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0020943 Vd NA 0.8448 L/kg 1compartment NA NA Rat Human DTXSID0020943 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0020943 TK.Half.Life NA 0.7313 hours 1compartment NA NA Rat Human -DTXSID0020943 Css NA 0.05794 mg/L 3compartmentss NA 50% Rat Human -DTXSID0020943 Css NA 0.3196 mg/L 3compartmentss NA 95% Rat Human -DTXSID0020943 Css NA 0.042 mg/L PBTK NA 50% Rat Human -DTXSID0020943 Css NA 0.2046 mg/L PBTK NA 95% Rat Human -DTXSID0021040 Clint NA 0.7143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021040 Fup NA 0.884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021040 Vd NA 1.259 L/kg 1compartment NA NA Human Human +DTXSID0020943 Css NA 0.01284 mg/L 3compartmentss NA 50% Rat Human +DTXSID0020943 Css NA 0.06985 mg/L 3compartmentss NA 95% Rat Human +DTXSID0020943 Css NA 0.00972 mg/L PBTK NA 50% Rat Human +DTXSID0020943 Css NA 0.04607 mg/L PBTK NA 95% Rat Human +DTXSID00210203 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00210203 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00210203 Vd NA 1.351 L/kg 1compartment NA NA Human Human +DTXSID00210203 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00210203 TK.Half.Life NA 4.498 hours 1compartment NA NA Human Human +DTXSID00210203 Css NA 0.308 mg/L 3compartmentss NA 50% Human Human +DTXSID00210203 Css NA 1.831 mg/L 3compartmentss NA 95% Human Human +DTXSID00210203 Css NA 0.226 mg/L PBTK NA 50% Human Human +DTXSID00210203 Css NA 1.237 mg/L PBTK NA 95% Human Human +DTXSID00210203 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00210203 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00210203 Vd NA 1.09 L/kg 1compartment NA NA Rat Human +DTXSID00210203 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00210203 TK.Half.Life NA 1.879 hours 1compartment NA NA Rat Human +DTXSID00210203 Css NA 0.03675 mg/L 3compartmentss NA 50% Rat Human +DTXSID00210203 Css NA 0.1549 mg/L 3compartmentss NA 95% Rat Human +DTXSID00210203 Css NA 0.02686 mg/L PBTK NA 50% Rat Human +DTXSID00210203 Css NA 0.1009 mg/L PBTK NA 95% Rat Human +DTXSID0021040 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021040 Fup 0.736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021040 Vd NA 1.127 L/kg 1compartment NA NA Human Human DTXSID0021040 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021040 TK.Half.Life NA 4.615 hours 1compartment NA NA Human Human -DTXSID0021040 Css NA 0.3949 mg/L 3compartmentss NA 50% Human Human -DTXSID0021040 Css NA 2.466 mg/L 3compartmentss NA 95% Human Human -DTXSID0021040 Css NA 0.3577 mg/L PBTK NA 50% Human Human -DTXSID0021040 Css NA 1.669 mg/L PBTK NA 95% Human Human -DTXSID0021040 Clint NA 0.7143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021040 Fup NA 0.884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021040 Vd NA 1.193 L/kg 1compartment NA NA Rat Human +DTXSID0021040 TK.Half.Life NA 0.8891 hours 1compartment NA NA Human Human +DTXSID0021040 Css NA 0.02678 mg/L 3compartmentss NA 50% Human Human +DTXSID0021040 Css NA 0.2796 mg/L 3compartmentss NA 95% Human Human +DTXSID0021040 Css NA 0.02314 mg/L PBTK NA 50% Human Human +DTXSID0021040 Css NA 0.2003 mg/L PBTK NA 95% Human Human +DTXSID0021040 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021040 Fup 0.736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021040 Vd NA 1.066 L/kg 1compartment NA NA Rat Human DTXSID0021040 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021040 TK.Half.Life NA 1.943 hours 1compartment NA NA Rat Human -DTXSID0021040 Css NA 0.1401 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021040 Css NA 0.8651 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021040 Css NA 0.1256 mg/L PBTK NA 50% Rat Human -DTXSID0021040 Css NA 0.5414 mg/L PBTK NA 95% Rat Human +DTXSID0021040 TK.Half.Life NA 0.4089 hours 1compartment NA NA Rat Human +DTXSID0021040 Css NA 0.003162 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021040 Css NA 0.02862 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021040 Css NA 0.002813 mg/L PBTK NA 50% Rat Human +DTXSID0021040 Css NA 0.02021 mg/L PBTK NA 95% Rat Human DTXSID0021094 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0021094 Fup 0.3284 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0021094 Vd NA 0.8918 L/kg 1compartment NA NA Human Human DTXSID0021094 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID0021094 TK.Half.Life NA 18.53 hours 1compartment NA NA Human Human -DTXSID0021094 Css NA 2.259 mg/L 3compartmentss NA 50% Human Human -DTXSID0021094 Css NA 9.251 mg/L 3compartmentss NA 95% Human Human -DTXSID0021094 Css NA 1.699 mg/L PBTK NA 50% Human Human -DTXSID0021094 Css NA 5.988 mg/L PBTK NA 95% Human Human +DTXSID0021094 Css NA 2.202 mg/L 3compartmentss NA 50% Human Human +DTXSID0021094 Css NA 9.026 mg/L 3compartmentss NA 95% Human Human +DTXSID0021094 Css NA 1.652 mg/L PBTK NA 50% Human Human +DTXSID0021094 Css NA 5.801 mg/L PBTK NA 95% Human Human DTXSID0021094 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0021094 Fup 0.3284 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0021094 Vd NA 0.7932 L/kg 1compartment NA NA Rat Human DTXSID0021094 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0021094 TK.Half.Life NA 5.394 hours 1compartment NA NA Rat Human -DTXSID0021094 Css NA 0.6243 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021094 Css NA 2.133 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021094 Css NA 0.4475 mg/L PBTK NA 50% Rat Human -DTXSID0021094 Css NA 1.283 mg/L PBTK NA 95% Rat Human -DTXSID0021096 Clint NA 16.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021096 Fup NA 0.1473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021096 Vd NA 1.283 L/kg 1compartment NA NA Human Human +DTXSID0021094 Css NA 0.1402 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021094 Css NA 0.4784 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021094 Css NA 0.1042 mg/L PBTK NA 50% Rat Human +DTXSID0021094 Css NA 0.2984 mg/L PBTK NA 95% Rat Human +DTXSID0021096 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021096 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021096 Vd NA 2.607 L/kg 1compartment NA NA Human Human DTXSID0021096 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021096 TK.Half.Life NA 3.154 hours 1compartment NA NA Human Human -DTXSID0021096 Css NA 0.247 mg/L 3compartmentss NA 50% Human Human -DTXSID0021096 Css NA 1.846 mg/L 3compartmentss NA 95% Human Human -DTXSID0021096 Css NA 0.1691 mg/L PBTK NA 50% Human Human -DTXSID0021096 Css NA 1.167 mg/L PBTK NA 95% Human Human -DTXSID0021096 Clint NA 16.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021096 Fup NA 0.1473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021096 Vd NA 1.019 L/kg 1compartment NA NA Rat Human +DTXSID0021096 TK.Half.Life NA 11.29 hours 1compartment NA NA Human Human +DTXSID0021096 Css NA 0.467 mg/L 3compartmentss NA 50% Human Human +DTXSID0021096 Css NA 3.096 mg/L 3compartmentss NA 95% Human Human +DTXSID0021096 Css NA 0.3248 mg/L PBTK NA 50% Human Human +DTXSID0021096 Css NA 2.082 mg/L PBTK NA 95% Human Human +DTXSID0021096 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021096 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021096 Vd NA 1.971 L/kg 1compartment NA NA Rat Human DTXSID0021096 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021096 TK.Half.Life NA 1.327 hours 1compartment NA NA Rat Human -DTXSID0021096 Css NA 0.1352 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021096 Css NA 0.7738 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021096 Css NA 0.0873 mg/L PBTK NA 50% Rat Human -DTXSID0021096 Css NA 0.4646 mg/L PBTK NA 95% Rat Human -DTXSID0021121 Clint NA 19.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021121 Fup NA 0.9743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021121 Vd NA 2.012 L/kg 1compartment NA NA Human Human +DTXSID0021096 TK.Half.Life NA 2.826 hours 1compartment NA NA Rat Human +DTXSID0021096 Css NA 0.06004 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021096 Css NA 0.3164 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021096 Css NA 0.04129 mg/L PBTK NA 50% Rat Human +DTXSID0021096 Css NA 0.2118 mg/L PBTK NA 95% Rat Human +DTXSID0021121 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021121 Fup 0.655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021121 Vd NA 0.5211 L/kg 1compartment NA NA Human Human DTXSID0021121 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021121 TK.Half.Life NA 1.263 hours 1compartment NA NA Human Human -DTXSID0021121 Css NA 0.02174 mg/L 3compartmentss NA 50% Human Human -DTXSID0021121 Css NA 0.3258 mg/L 3compartmentss NA 95% Human Human -DTXSID0021121 Css NA 0.02169 mg/L PBTK NA 50% Human Human -DTXSID0021121 Css NA 0.2618 mg/L PBTK NA 95% Human Human -DTXSID0021121 Clint NA 19.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021121 Fup NA 0.9743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021121 Vd NA 2.064 L/kg 1compartment NA NA Rat Human +DTXSID0021121 TK.Half.Life NA 0.7544 hours 1compartment NA NA Human Human +DTXSID0021121 Css NA 0.1123 mg/L 3compartmentss NA 50% Human Human +DTXSID0021121 Css NA 0.9666 mg/L 3compartmentss NA 95% Human Human +DTXSID0021121 Css NA 0.08259 mg/L PBTK NA 50% Human Human +DTXSID0021121 Css NA 0.6247 mg/L PBTK NA 95% Human Human +DTXSID0021121 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021121 Fup 0.655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021121 Vd NA 0.527 L/kg 1compartment NA NA Rat Human DTXSID0021121 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021121 TK.Half.Life NA 0.6371 hours 1compartment NA NA Rat Human -DTXSID0021121 Css NA 0.01055 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021121 Css NA 0.1312 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021121 Css NA 0.01072 mg/L PBTK NA 50% Rat Human -DTXSID0021121 Css NA 0.09925 mg/L PBTK NA 95% Rat Human +DTXSID0021121 TK.Half.Life NA 0.4049 hours 1compartment NA NA Rat Human +DTXSID0021121 Css NA 0.01246 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021121 Css NA 0.0939 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021121 Css NA 0.009315 mg/L PBTK NA 50% Rat Human +DTXSID0021121 Css NA 0.05784 mg/L PBTK NA 95% Rat Human DTXSID0021123 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0021123 Fup 0.247 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0021123 Vd NA 0.4098 L/kg 1compartment NA NA Human Human +DTXSID0021123 Vd NA 0.4177 L/kg 1compartment NA NA Human Human DTXSID0021123 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0021123 TK.Half.Life NA 10.79 hours 1compartment NA NA Human Human -DTXSID0021123 Css NA 3.21 mg/L 3compartmentss NA 50% Human Human -DTXSID0021123 Css NA 9.418 mg/L 3compartmentss NA 95% Human Human -DTXSID0021123 Css NA 2.122 mg/L PBTK NA 50% Human Human -DTXSID0021123 Css NA 5.816 mg/L PBTK NA 95% Human Human +DTXSID0021123 TK.Half.Life NA 11 hours 1compartment NA NA Human Human +DTXSID0021123 Css NA 3.095 mg/L 3compartmentss NA 50% Human Human +DTXSID0021123 Css NA 9.153 mg/L 3compartmentss NA 95% Human Human +DTXSID0021123 Css NA 2.066 mg/L PBTK NA 50% Human Human +DTXSID0021123 Css NA 5.783 mg/L PBTK NA 95% Human Human DTXSID0021123 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0021123 Fup 0.247 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0021123 Vd NA 0.3947 L/kg 1compartment NA NA Rat Human +DTXSID0021123 Vd NA 0.4004 L/kg 1compartment NA NA Rat Human DTXSID0021123 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021123 TK.Half.Life NA 3.527 hours 1compartment NA NA Rat Human -DTXSID0021123 Css NA 0.8817 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021123 Css NA 2.096 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021123 Css NA 0.5555 mg/L PBTK NA 50% Rat Human -DTXSID0021123 Css NA 1.218 mg/L PBTK NA 95% Rat Human +DTXSID0021123 TK.Half.Life NA 3.578 hours 1compartment NA NA Rat Human +DTXSID0021123 Css NA 0.1984 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021123 Css NA 0.4843 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021123 Css NA 0.1297 mg/L PBTK NA 50% Rat Human +DTXSID0021123 Css NA 0.2914 mg/L PBTK NA 95% Rat Human DTXSID0021125 Clint 47.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0021125 Fup 0.03116 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID0021125 Vd NA 1.012 L/kg 1compartment NA NA Human Human +DTXSID0021125 Vd NA 0.2842 L/kg 1compartment NA NA Human Human DTXSID0021125 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021125 TK.Half.Life NA 3.435 hours 1compartment NA NA Human Human -DTXSID0021125 Css NA 0.455 mg/L 3compartmentss NA 50% Human Human -DTXSID0021125 Css NA 4.251 mg/L 3compartmentss NA 95% Human Human -DTXSID0021125 Css NA 0.2811 mg/L PBTK NA 50% Human Human -DTXSID0021125 Css NA 2.487 mg/L PBTK NA 95% Human Human +DTXSID0021125 TK.Half.Life NA 0.9884 hours 1compartment NA NA Human Human +DTXSID0021125 Css NA 0.4694 mg/L 3compartmentss NA 50% Human Human +DTXSID0021125 Css NA 4.748 mg/L 3compartmentss NA 95% Human Human +DTXSID0021125 Css NA 0.2806 mg/L PBTK NA 50% Human Human +DTXSID0021125 Css NA 2.789 mg/L PBTK NA 95% Human Human DTXSID0021125 Clint 41.6 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0021125 Fup 0.0086 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID0021125 Vd NA 0.4046 L/kg 1compartment NA NA Rat Rat +DTXSID0021125 Vd 0.036 0.1897 L/kg 1compartment National Toxicology Program NA Rat Rat DTXSID0021125 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID0021125 TK.Half.Life NA 2.654 hours 1compartment NA NA Rat Rat -DTXSID0021125 Css NA 0.9972 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0021125 Css NA 8.763 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0021125 Css NA 0.5496 mg/L PBTK NA 50% Rat Rat -DTXSID0021125 Css NA 4.781 mg/L PBTK NA 95% Rat Rat -DTXSID0021127 Clint NA 28.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021127 Fup NA 0.0303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021127 Vd NA 1.795 L/kg 1compartment NA NA Human Human +DTXSID0021125 TK.Half.Life 0.022 1.452 hours 1compartment National Toxicology Program NA Rat Rat +DTXSID0021125 Css 0.035 0.2666 mg/L 3compartmentss National Toxicology Program 50% Rat Rat +DTXSID0021125 Css 0.035 2.225 mg/L 3compartmentss National Toxicology Program 95% Rat Rat +DTXSID0021125 Css 0.035 0.1506 mg/L PBTK National Toxicology Program 50% Rat Rat +DTXSID0021125 Css 0.035 1.247 mg/L PBTK National Toxicology Program 95% Rat Rat +DTXSID0021127 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021127 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021127 Vd NA 3.065 L/kg 1compartment NA NA Human Human DTXSID0021127 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021127 TK.Half.Life NA 7.208 hours 1compartment NA NA Human Human -DTXSID0021127 Css NA 0.5234 mg/L 3compartmentss NA 50% Human Human -DTXSID0021127 Css NA 4.96 mg/L 3compartmentss NA 95% Human Human -DTXSID0021127 Css NA 0.3522 mg/L PBTK NA 50% Human Human -DTXSID0021127 Css NA 3.119 mg/L PBTK NA 95% Human Human -DTXSID0021127 Clint NA 28.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021127 Fup NA 0.0303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021127 Vd NA 1.497 L/kg 1compartment NA NA Rat Human +DTXSID0021127 TK.Half.Life NA 8.619 hours 1compartment NA NA Human Human +DTXSID0021127 Css NA 0.2573 mg/L 3compartmentss NA 50% Human Human +DTXSID0021127 Css NA 1.91 mg/L 3compartmentss NA 95% Human Human +DTXSID0021127 Css NA 0.2017 mg/L PBTK NA 50% Human Human +DTXSID0021127 Css NA 1.401 mg/L PBTK NA 95% Human Human +DTXSID0021127 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021127 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021127 Vd NA 2.569 L/kg 1compartment NA NA Rat Human DTXSID0021127 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021127 TK.Half.Life NA 3.228 hours 1compartment NA NA Rat Human -DTXSID0021127 Css NA 0.298 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021127 Css NA 2.284 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021127 Css NA 0.1891 mg/L PBTK NA 50% Rat Human -DTXSID0021127 Css NA 1.324 mg/L PBTK NA 95% Rat Human -DTXSID0021129 Clint NA 2.445 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021129 Fup NA 0.2375 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021129 Vd NA 2.733 L/kg 1compartment NA NA Human Human -DTXSID0021129 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID0021129 TK.Half.Life NA 49.3 hours 1compartment NA NA Human Human -DTXSID0021129 Css NA 2.055 mg/L 3compartmentss NA 50% Human Human -DTXSID0021129 Css NA 8.988 mg/L 3compartmentss NA 95% Human Human -DTXSID0021129 Css NA 1.493 mg/L PBTK NA 50% Human Human -DTXSID0021129 Css NA 6.123 mg/L PBTK NA 95% Human Human -DTXSID0021129 Clint NA 2.445 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021129 Fup NA 0.2375 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021129 Vd NA 2.077 L/kg 1compartment NA NA Rat Human -DTXSID0021129 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0021129 TK.Half.Life NA 9.541 hours 1compartment NA NA Rat Human -DTXSID0021129 Css NA 0.9916 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021129 Css NA 2.915 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021129 Css NA 0.6958 mg/L PBTK NA 50% Rat Human -DTXSID0021129 Css NA 1.871 mg/L PBTK NA 95% Rat Human -DTXSID0021175 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021175 Fup NA 0.0369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021175 Vd NA 3.105 L/kg 1compartment NA NA Human Human -DTXSID0021175 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID0021175 TK.Half.Life NA 30480 hours 1compartment NA NA Human Human -DTXSID0021175 Css NA 1130 mg/L 3compartmentss NA 50% Human Human -DTXSID0021175 Css NA 3091 mg/L 3compartmentss NA 95% Human Human -DTXSID0021175 Css NA 786.8 mg/L PBTK NA 50% Human Human -DTXSID0021175 Css NA 2001 mg/L PBTK NA 95% Human Human -DTXSID0021175 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021175 Fup NA 0.0369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021175 Vd NA 2.326 L/kg 1compartment NA NA Rat Human -DTXSID0021175 Days.Css NA 2137 Days PBTK NA NA Rat Human -DTXSID0021175 TK.Half.Life NA 1961 hours 1compartment NA NA Rat Human -DTXSID0021175 Css NA 306.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021175 Css NA 683.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021175 Css NA 204.1 mg/L PBTK NA 50% Rat Human -DTXSID0021175 Css NA 411.6 mg/L PBTK NA 95% Rat Human -DTXSID0021179 Clint NA 14.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0021127 TK.Half.Life NA 2.811 hours 1compartment NA NA Rat Human +DTXSID0021127 Css NA 0.03294 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021127 Css NA 0.1913 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021127 Css NA 0.02592 mg/L PBTK NA 50% Rat Human +DTXSID0021127 Css NA 0.1372 mg/L PBTK NA 95% Rat Human +DTXSID0021129 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021129 Fup 0.0821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021129 Vd NA 2.151 L/kg 1compartment NA NA Human Human +DTXSID0021129 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0021129 TK.Half.Life NA 8.771 hours 1compartment NA NA Human Human +DTXSID0021129 Css NA 0.4719 mg/L 3compartmentss NA 50% Human Human +DTXSID0021129 Css NA 3.338 mg/L 3compartmentss NA 95% Human Human +DTXSID0021129 Css NA 0.319 mg/L PBTK NA 50% Human Human +DTXSID0021129 Css NA 2.127 mg/L PBTK NA 95% Human Human +DTXSID0021129 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021129 Fup 0.0821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021129 Vd NA 1.621 L/kg 1compartment NA NA Rat Human +DTXSID0021129 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0021129 TK.Half.Life NA 2.721 hours 1compartment NA NA Rat Human +DTXSID0021129 Css NA 0.06118 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021129 Css NA 0.3292 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021129 Css NA 0.04064 mg/L PBTK NA 50% Rat Human +DTXSID0021129 Css NA 0.2092 mg/L PBTK NA 95% Rat Human +DTXSID0021179 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0021179 Fup 0.93 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0021179 Vd NA 1.596 L/kg 1compartment NA NA Human Human DTXSID0021179 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021179 TK.Half.Life NA 1.176 hours 1compartment NA NA Human Human -DTXSID0021179 Css NA 0.03139 mg/L 3compartmentss NA 50% Human Human -DTXSID0021179 Css NA 0.2228 mg/L 3compartmentss NA 95% Human Human -DTXSID0021179 Css NA 0.02922 mg/L PBTK NA 50% Human Human -DTXSID0021179 Css NA 0.1854 mg/L PBTK NA 95% Human Human -DTXSID0021179 Clint NA 14.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0021179 TK.Half.Life NA 1.665 hours 1compartment NA NA Human Human +DTXSID0021179 Css NA 0.05198 mg/L 3compartmentss NA 50% Human Human +DTXSID0021179 Css NA 0.3403 mg/L 3compartmentss NA 95% Human Human +DTXSID0021179 Css NA 0.04924 mg/L PBTK NA 50% Human Human +DTXSID0021179 Css NA 0.2837 mg/L PBTK NA 95% Human Human +DTXSID0021179 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0021179 Fup 0.93 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0021179 Vd NA 1.568 L/kg 1compartment NA NA Rat Human DTXSID0021179 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021179 TK.Half.Life NA 0.5728 hours 1compartment NA NA Rat Human -DTXSID0021179 Css NA 0.01547 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021179 Css NA 0.08721 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021179 Css NA 0.01474 mg/L PBTK NA 50% Rat Human -DTXSID0021179 Css NA 0.07149 mg/L PBTK NA 95% Rat Human +DTXSID0021179 TK.Half.Life NA 0.8525 hours 1compartment NA NA Rat Human +DTXSID0021179 Css NA 0.001122 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021179 Css NA 0.009979 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021179 Css NA 0.001061 mg/L PBTK NA 50% Rat Human +DTXSID0021179 Css NA 0.00823 mg/L PBTK NA 95% Rat Human DTXSID0021206 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021206 Fup NA 0.8561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021206 Vd NA 0.7254 L/kg 1compartment NA NA Human Human DTXSID0021206 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0021206 TK.Half.Life NA 5.488 hours 1compartment NA NA Human Human -DTXSID0021206 Css NA 0.963 mg/L 3compartmentss NA 50% Human Human -DTXSID0021206 Css NA 5.697 mg/L 3compartmentss NA 95% Human Human -DTXSID0021206 Css NA 0.7882 mg/L PBTK NA 50% Human Human -DTXSID0021206 Css NA 3.647 mg/L PBTK NA 95% Human Human +DTXSID0021206 Css NA 0.8171 mg/L 3compartmentss NA 50% Human Human +DTXSID0021206 Css NA 4.973 mg/L 3compartmentss NA 95% Human Human +DTXSID0021206 Css NA 0.668 mg/L PBTK NA 50% Human Human +DTXSID0021206 Css NA 3.23 mg/L PBTK NA 95% Human Human DTXSID0021206 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021206 Fup NA 0.8561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021206 Vd NA 0.7569 L/kg 1compartment NA NA Rat Human DTXSID0021206 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0021206 TK.Half.Life NA 1.95 hours 1compartment NA NA Rat Human -DTXSID0021206 Css NA 0.2449 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021206 Css NA 1.419 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021206 Css NA 0.1953 mg/L PBTK NA 50% Rat Human -DTXSID0021206 Css NA 0.8502 mg/L PBTK NA 95% Rat Human +DTXSID0021206 Css NA 0.01552 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021206 Css NA 0.109 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021206 Css NA 0.01222 mg/L PBTK NA 50% Rat Human +DTXSID0021206 Css NA 0.07094 mg/L PBTK NA 95% Rat Human +DTXSID0021254 Clint 14.12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID0021254 Fup 0.01789 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID0021254 Vd NA 0.3565 L/kg 1compartment NA NA Human Human +DTXSID0021254 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0021254 TK.Half.Life NA 5.299 hours 1compartment NA NA Human Human +DTXSID0021254 Css NA 2.552 mg/L 3compartmentss NA 50% Human Human +DTXSID0021254 Css NA 23.58 mg/L 3compartmentss NA 95% Human Human +DTXSID0021254 Css NA 1.524 mg/L PBTK NA 50% Human Human +DTXSID0021254 Css NA 14.04 mg/L PBTK NA 95% Human Human +DTXSID0021254 Clint 14.12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID0021254 Fup 0.01789 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID0021254 Vd NA 0.2936 L/kg 1compartment NA NA Rat Human +DTXSID0021254 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0021254 TK.Half.Life NA 2.842 hours 1compartment NA NA Rat Human +DTXSID0021254 Css NA 0.3376 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021254 Css NA 2.559 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021254 Css NA 0.1925 mg/L PBTK NA 50% Rat Human +DTXSID0021254 Css NA 1.437 mg/L PBTK NA 95% Rat Human DTXSID0021256 Clint 5.16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0021256 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0021256 Vd NA 0.1699 L/kg 1compartment NA NA Human Human +DTXSID0021256 Vd NA 0.1708 L/kg 1compartment NA NA Human Human DTXSID0021256 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID0021256 TK.Half.Life NA 28.93 hours 1compartment NA NA Human Human -DTXSID0021256 Css NA 32.3 mg/L 3compartmentss NA 50% Human Human -DTXSID0021256 Css NA 186.9 mg/L 3compartmentss NA 95% Human Human -DTXSID0021256 Css NA 18.83 mg/L PBTK NA 50% Human Human -DTXSID0021256 Css NA 106.9 mg/L PBTK NA 95% Human Human +DTXSID0021256 TK.Half.Life NA 29.09 hours 1compartment NA NA Human Human +DTXSID0021256 Css NA 8.293 mg/L 3compartmentss NA 50% Human Human +DTXSID0021256 Css NA 52.36 mg/L 3compartmentss NA 95% Human Human +DTXSID0021256 Css NA 4.856 mg/L PBTK NA 50% Human Human +DTXSID0021256 Css NA 30.5 mg/L PBTK NA 95% Human Human DTXSID0021256 Clint 5.16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0021256 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0021256 Vd NA 0.1674 L/kg 1compartment NA NA Rat Human +DTXSID0021256 Vd NA 0.1681 L/kg 1compartment NA NA Rat Human DTXSID0021256 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0021256 TK.Half.Life NA 17.99 hours 1compartment NA NA Rat Human -DTXSID0021256 Css NA 16.92 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021256 Css NA 70.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021256 Css NA 9.164 mg/L PBTK NA 50% Rat Human -DTXSID0021256 Css NA 37.95 mg/L PBTK NA 95% Rat Human -DTXSID0021258 Clint NA 37.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021258 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021258 Vd NA 0.8566 L/kg 1compartment NA NA Human Human +DTXSID0021256 TK.Half.Life NA 18.06 hours 1compartment NA NA Rat Human +DTXSID0021256 Css NA 0.06818 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021256 Css NA 0.3134 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021256 Css NA 0.03705 mg/L PBTK NA 50% Rat Human +DTXSID0021256 Css NA 0.1699 mg/L PBTK NA 95% Rat Human +DTXSID0021258 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021258 Fup 0.51 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021258 Vd NA 1.31 L/kg 1compartment NA NA Human Human DTXSID0021258 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021258 TK.Half.Life NA 0.8857 hours 1compartment NA NA Human Human -DTXSID0021258 Css NA 0.0387 mg/L 3compartmentss NA 50% Human Human -DTXSID0021258 Css NA 0.2997 mg/L 3compartmentss NA 95% Human Human -DTXSID0021258 Css NA 0.02872 mg/L PBTK NA 50% Human Human -DTXSID0021258 Css NA 0.2061 mg/L PBTK NA 95% Human Human -DTXSID0021258 Clint NA 37.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021258 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021258 Vd NA 0.8182 L/kg 1compartment NA NA Rat Human +DTXSID0021258 TK.Half.Life NA 2.197 hours 1compartment NA NA Human Human +DTXSID0021258 Css NA 0.1184 mg/L 3compartmentss NA 50% Human Human +DTXSID0021258 Css NA 0.9616 mg/L 3compartmentss NA 95% Human Human +DTXSID0021258 Css NA 0.1002 mg/L PBTK NA 50% Human Human +DTXSID0021258 Css NA 0.6755 mg/L PBTK NA 95% Human Human +DTXSID0021258 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021258 Fup 0.51 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021258 Vd NA 1.231 L/kg 1compartment NA NA Rat Human DTXSID0021258 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021258 TK.Half.Life NA 0.4247 hours 1compartment NA NA Rat Human -DTXSID0021258 Css NA 0.02098 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021258 Css NA 0.1287 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021258 Css NA 0.015 mg/L PBTK NA 50% Rat Human -DTXSID0021258 Css NA 0.08285 mg/L PBTK NA 95% Rat Human +DTXSID0021258 TK.Half.Life NA 1.112 hours 1compartment NA NA Rat Human +DTXSID0021258 Css NA 0.01376 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021258 Css NA 0.08515 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021258 Css NA 0.01178 mg/L PBTK NA 50% Rat Human +DTXSID0021258 Css NA 0.05647 mg/L PBTK NA 95% Rat Human DTXSID0021331 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021331 Fup NA 0.9144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021331 Vd NA 0.7302 L/kg 1compartment NA NA Human Human +DTXSID0021331 Vd NA 0.743 L/kg 1compartment NA NA Human Human DTXSID0021331 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021331 TK.Half.Life NA 5.169 hours 1compartment NA NA Human Human -DTXSID0021331 Css NA 0.887 mg/L 3compartmentss NA 50% Human Human -DTXSID0021331 Css NA 3.217 mg/L 3compartmentss NA 95% Human Human -DTXSID0021331 Css NA 0.734 mg/L PBTK NA 50% Human Human -DTXSID0021331 Css NA 2.244 mg/L PBTK NA 95% Human Human +DTXSID0021331 TK.Half.Life NA 5.259 hours 1compartment NA NA Human Human +DTXSID0021331 Css NA 0.7632 mg/L 3compartmentss NA 50% Human Human +DTXSID0021331 Css NA 2.865 mg/L 3compartmentss NA 95% Human Human +DTXSID0021331 Css NA 0.6357 mg/L PBTK NA 50% Human Human +DTXSID0021331 Css NA 2.006 mg/L PBTK NA 95% Human Human DTXSID0021331 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021331 Fup NA 0.9144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021331 Vd NA 0.7667 L/kg 1compartment NA NA Rat Human +DTXSID0021331 Vd NA 0.7778 L/kg 1compartment NA NA Rat Human DTXSID0021331 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021331 TK.Half.Life NA 1.849 hours 1compartment NA NA Rat Human -DTXSID0021331 Css NA 0.2296 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021331 Css NA 0.7961 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021331 Css NA 0.185 mg/L PBTK NA 50% Rat Human -DTXSID0021331 Css NA 0.507 mg/L PBTK NA 95% Rat Human +DTXSID0021331 TK.Half.Life NA 1.876 hours 1compartment NA NA Rat Human +DTXSID0021331 Css NA 0.01885 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021331 Css NA 0.09487 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021331 Css NA 0.0151 mg/L PBTK NA 50% Rat Human +DTXSID0021331 Css NA 0.06687 mg/L PBTK NA 95% Rat Human DTXSID0021333 Clint 18.06 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID0021333 Fup 0.6276 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID0021333 Vd NA 1.018 L/kg 1compartment NA NA Human Human +DTXSID0021333 Vd NA 1.153 L/kg 1compartment NA NA Human Human DTXSID0021333 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021333 TK.Half.Life NA 0.9315 hours 1compartment NA NA Human Human -DTXSID0021333 Css NA 0.03366 mg/L 3compartmentss NA 50% Human Human -DTXSID0021333 Css NA 0.2032 mg/L 3compartmentss NA 95% Human Human -DTXSID0021333 Css NA 0.02874 mg/L PBTK NA 50% Human Human -DTXSID0021333 Css NA 0.164 mg/L PBTK NA 95% Human Human +DTXSID0021333 TK.Half.Life NA 1.055 hours 1compartment NA NA Human Human +DTXSID0021333 Css NA 0.03061 mg/L 3compartmentss NA 50% Human Human +DTXSID0021333 Css NA 0.2015 mg/L 3compartmentss NA 95% Human Human +DTXSID0021333 Css NA 0.02665 mg/L PBTK NA 50% Human Human +DTXSID0021333 Css NA 0.1602 mg/L PBTK NA 95% Human Human DTXSID0021333 Clint 18.06 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID0021333 Fup 0.6276 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID0021333 Vd NA 0.9584 L/kg 1compartment NA NA Rat Human +DTXSID0021333 Vd NA 1.057 L/kg 1compartment NA NA Rat Human DTXSID0021333 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021333 TK.Half.Life NA 0.4381 hours 1compartment NA NA Rat Human -DTXSID0021333 Css NA 0.0171 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021333 Css NA 0.0833 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021333 Css NA 0.01446 mg/L PBTK NA 50% Rat Human -DTXSID0021333 Css NA 0.06504 mg/L PBTK NA 95% Rat Human -DTXSID0021335 Clint NA 5.896 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021335 Fup NA 0.3042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021335 Vd NA 2.342 L/kg 1compartment NA NA Human Human +DTXSID0021333 TK.Half.Life NA 0.4797 hours 1compartment NA NA Rat Human +DTXSID0021333 Css NA 0.003746 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021333 Css NA 0.01825 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021333 Css NA 0.003332 mg/L PBTK NA 50% Rat Human +DTXSID0021333 Css NA 0.01516 mg/L PBTK NA 95% Rat Human +DTXSID0021335 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021335 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021335 Vd NA 3.05 L/kg 1compartment NA NA Human Human DTXSID0021335 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021335 TK.Half.Life NA 5.945 hours 1compartment NA NA Human Human -DTXSID0021335 Css NA 0.1957 mg/L 3compartmentss NA 50% Human Human -DTXSID0021335 Css NA 1.206 mg/L 3compartmentss NA 95% Human Human -DTXSID0021335 Css NA 0.1802 mg/L PBTK NA 50% Human Human -DTXSID0021335 Css NA 0.9477 mg/L PBTK NA 95% Human Human -DTXSID0021335 Clint NA 5.896 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021335 Fup NA 0.3042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021335 Vd NA 2.252 L/kg 1compartment NA NA Rat Human +DTXSID0021335 TK.Half.Life NA 3.767 hours 1compartment NA NA Human Human +DTXSID0021335 Css NA 0.06128 mg/L 3compartmentss NA 50% Human Human +DTXSID0021335 Css NA 0.4839 mg/L 3compartmentss NA 95% Human Human +DTXSID0021335 Css NA 0.05842 mg/L PBTK NA 50% Human Human +DTXSID0021335 Css NA 0.3948 mg/L PBTK NA 95% Human Human +DTXSID0021335 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021335 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021335 Vd NA 2.801 L/kg 1compartment NA NA Rat Human DTXSID0021335 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021335 TK.Half.Life NA 3.131 hours 1compartment NA NA Rat Human -DTXSID0021335 Css NA 0.09742 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021335 Css NA 0.4725 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021335 Css NA 0.0883 mg/L PBTK NA 50% Rat Human -DTXSID0021335 Css NA 0.3414 mg/L PBTK NA 95% Rat Human +DTXSID0021335 TK.Half.Life NA 1.644 hours 1compartment NA NA Rat Human +DTXSID0021335 Css NA 0.007611 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021335 Css NA 0.04512 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021335 Css NA 0.007426 mg/L PBTK NA 50% Rat Human +DTXSID0021335 Css NA 0.03786 mg/L PBTK NA 95% Rat Human DTXSID0021337 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0021337 Fup 0.1382 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0021337 Vd NA 1.396 L/kg 1compartment NA NA Human Human DTXSID0021337 Days.Css NA 15 Days PBTK NA NA Human Human DTXSID0021337 TK.Half.Life NA 84.73 hours 1compartment NA NA Human Human -DTXSID0021337 Css NA 8.074 mg/L 3compartmentss NA 50% Human Human -DTXSID0021337 Css NA 35.55 mg/L 3compartmentss NA 95% Human Human -DTXSID0021337 Css NA 5.467 mg/L PBTK NA 50% Human Human -DTXSID0021337 Css NA 21.58 mg/L PBTK NA 95% Human Human +DTXSID0021337 Css NA 7.9 mg/L 3compartmentss NA 50% Human Human +DTXSID0021337 Css NA 33.85 mg/L 3compartmentss NA 95% Human Human +DTXSID0021337 Css NA 5.354 mg/L PBTK NA 50% Human Human +DTXSID0021337 Css NA 20.71 mg/L PBTK NA 95% Human Human DTXSID0021337 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0021337 Fup 0.1382 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0021337 Vd NA 1.089 L/kg 1compartment NA NA Rat Human DTXSID0021337 Days.Css NA 3 Days PBTK NA NA Rat Human DTXSID0021337 TK.Half.Life NA 18.6 hours 1compartment NA NA Rat Human -DTXSID0021337 Css NA 2.256 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021337 Css NA 7.974 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021337 Css NA 1.451 mg/L PBTK NA 50% Rat Human -DTXSID0021337 Css NA 4.567 mg/L PBTK NA 95% Rat Human -DTXSID0021339 Clint NA 0.02275 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0021337 Css NA 0.5112 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021337 Css NA 1.788 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021337 Css NA 0.3407 mg/L PBTK NA 50% Rat Human +DTXSID0021337 Css NA 1.062 mg/L PBTK NA 95% Rat Human +DTXSID0021339 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0021339 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0021339 Vd NA 1.048 L/kg 1compartment NA NA Human Human DTXSID0021339 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021339 TK.Half.Life NA 7.42 hours 1compartment NA NA Human Human -DTXSID0021339 Css NA 0.7997 mg/L 3compartmentss NA 50% Human Human -DTXSID0021339 Css NA 3.271 mg/L 3compartmentss NA 95% Human Human -DTXSID0021339 Css NA 0.7108 mg/L PBTK NA 50% Human Human -DTXSID0021339 Css NA 2.344 mg/L PBTK NA 95% Human Human -DTXSID0021339 Clint NA 0.02275 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0021339 TK.Half.Life NA 0.7451 hours 1compartment NA NA Human Human +DTXSID0021339 Css NA 0.02192 mg/L 3compartmentss NA 50% Human Human +DTXSID0021339 Css NA 0.1775 mg/L 3compartmentss NA 95% Human Human +DTXSID0021339 Css NA 0.01912 mg/L PBTK NA 50% Human Human +DTXSID0021339 Css NA 0.1364 mg/L PBTK NA 95% Human Human +DTXSID0021339 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0021339 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0021339 Vd NA 1.027 L/kg 1compartment NA NA Rat Human DTXSID0021339 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021339 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human -DTXSID0021339 Css NA 0.2094 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021339 Css NA 0.7881 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021339 Css NA 0.1829 mg/L PBTK NA 50% Rat Human -DTXSID0021339 Css NA 0.5179 mg/L PBTK NA 95% Rat Human -DTXSID0021387 Clint NA 0.05915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021387 Fup NA 0.0119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021387 Vd NA 0.2466 L/kg 1compartment NA NA Human Human -DTXSID0021387 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID0021387 TK.Half.Life NA 122.1 hours 1compartment NA NA Human Human -DTXSID0021387 Css NA 83.29 mg/L 3compartmentss NA 50% Human Human -DTXSID0021387 Css NA 534.4 mg/L 3compartmentss NA 95% Human Human -DTXSID0021387 Css NA 49.54 mg/L PBTK NA 50% Human Human -DTXSID0021387 Css NA 309.6 mg/L PBTK NA 95% Human Human -DTXSID0021387 Clint NA 0.05915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021387 Fup NA 0.0119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021387 Vd NA 0.2374 L/kg 1compartment NA NA Rat Human -DTXSID0021387 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID0021387 TK.Half.Life NA 41.96 hours 1compartment NA NA Rat Human -DTXSID0021387 Css NA 25.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021387 Css NA 141.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021387 Css NA 13.93 mg/L PBTK NA 50% Rat Human -DTXSID0021387 Css NA 77.03 mg/L PBTK NA 95% Rat Human +DTXSID0021339 TK.Half.Life NA 0.3508 hours 1compartment NA NA Rat Human +DTXSID0021339 Css NA 0.002568 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021339 Css NA 0.01649 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021339 Css NA 0.002314 mg/L PBTK NA 50% Rat Human +DTXSID0021339 Css NA 0.01308 mg/L PBTK NA 95% Rat Human +DTXSID0021387 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021387 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021387 Vd NA 0.3499 L/kg 1compartment NA NA Human Human +DTXSID0021387 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0021387 TK.Half.Life NA 6.743 hours 1compartment NA NA Human Human +DTXSID0021387 Css NA 3.258 mg/L 3compartmentss NA 50% Human Human +DTXSID0021387 Css NA 28.77 mg/L 3compartmentss NA 95% Human Human +DTXSID0021387 Css NA 2.011 mg/L PBTK NA 50% Human Human +DTXSID0021387 Css NA 16.99 mg/L PBTK NA 95% Human Human +DTXSID0021387 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021387 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021387 Vd NA 0.3373 L/kg 1compartment NA NA Rat Human +DTXSID0021387 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0021387 TK.Half.Life NA 4.101 hours 1compartment NA NA Rat Human +DTXSID0021387 Css NA 0.3988 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021387 Css NA 2.702 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021387 Css NA 0.2398 mg/L PBTK NA 50% Rat Human +DTXSID0021387 Css NA 1.54 mg/L PBTK NA 95% Rat Human DTXSID0021389 Clint 31.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0021389 Fup 0.696 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0021389 Vd NA 0.8886 L/kg 1compartment NA NA Human Human DTXSID0021389 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0021389 TK.Half.Life NA 0.673 hours 1compartment NA NA Human Human -DTXSID0021389 Css NA 0.02025 mg/L 3compartmentss NA 50% Human Human -DTXSID0021389 Css NA 0.1488 mg/L 3compartmentss NA 95% Human Human -DTXSID0021389 Css NA 0.01679 mg/L PBTK NA 50% Human Human -DTXSID0021389 Css NA 0.1095 mg/L PBTK NA 95% Human Human +DTXSID0021389 Css NA 0.01768 mg/L 3compartmentss NA 50% Human Human +DTXSID0021389 Css NA 0.1408 mg/L 3compartmentss NA 95% Human Human +DTXSID0021389 Css NA 0.01486 mg/L PBTK NA 50% Human Human +DTXSID0021389 Css NA 0.1046 mg/L PBTK NA 95% Human Human DTXSID0021389 Clint 31.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0021389 Fup 0.696 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0021389 Vd NA 0.8707 L/kg 1compartment NA NA Rat Human DTXSID0021389 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0021389 TK.Half.Life NA 0.3138 hours 1compartment NA NA Rat Human -DTXSID0021389 Css NA 0.01036 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021389 Css NA 0.06737 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021389 Css NA 0.008458 mg/L PBTK NA 50% Rat Human -DTXSID0021389 Css NA 0.04821 mg/L PBTK NA 95% Rat Human -DTXSID0021410 Clint NA 15.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021410 Fup NA 0.1282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021410 Vd NA 3.341 L/kg 1compartment NA NA Human Human +DTXSID0021389 Css NA 0.002147 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021389 Css NA 0.01475 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021389 Css NA 0.001824 mg/L PBTK NA 50% Rat Human +DTXSID0021389 Css NA 0.01103 mg/L PBTK NA 95% Rat Human +DTXSID0021410 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021410 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021410 Vd NA 3.675 L/kg 1compartment NA NA Human Human DTXSID0021410 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021410 TK.Half.Life NA 9.233 hours 1compartment NA NA Human Human -DTXSID0021410 Css NA 0.2504 mg/L 3compartmentss NA 50% Human Human -DTXSID0021410 Css NA 1.881 mg/L 3compartmentss NA 95% Human Human -DTXSID0021410 Css NA 0.2119 mg/L PBTK NA 50% Human Human -DTXSID0021410 Css NA 1.421 mg/L PBTK NA 95% Human Human -DTXSID0021410 Clint NA 15.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021410 Fup NA 0.1282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021410 Vd NA 2.918 L/kg 1compartment NA NA Rat Human +DTXSID0021410 TK.Half.Life NA 12.88 hours 1compartment NA NA Human Human +DTXSID0021410 Css NA 0.259 mg/L 3compartmentss NA 50% Human Human +DTXSID0021410 Css NA 1.608 mg/L 3compartmentss NA 95% Human Human +DTXSID0021410 Css NA 0.2602 mg/L PBTK NA 50% Human Human +DTXSID0021410 Css NA 1.408 mg/L PBTK NA 95% Human Human +DTXSID0021410 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021410 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021410 Vd NA 3.4 L/kg 1compartment NA NA Rat Human DTXSID0021410 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021410 TK.Half.Life NA 3.285 hours 1compartment NA NA Rat Human -DTXSID0021410 Css NA 0.1339 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021410 Css NA 0.7693 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021410 Css NA 0.1107 mg/L PBTK NA 50% Rat Human -DTXSID0021410 Css NA 0.5597 mg/L PBTK NA 95% Rat Human -DTXSID0021414 Clint NA 350.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021414 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021414 Vd NA 1073 L/kg 1compartment NA NA Human Human -DTXSID0021414 Days.Css NA 509 Days PBTK NA NA Human Human -DTXSID0021414 TK.Half.Life NA 2010 hours 1compartment NA NA Human Human -DTXSID0021414 Css NA 0.000904 mg/L 3compartmentss NA 50% Human Human -DTXSID0021414 Css NA 0.005682 mg/L 3compartmentss NA 95% Human Human -DTXSID0021414 Css NA 0.1548 mg/L PBTK NA 50% Human Human -DTXSID0021414 Css NA 0.8992 mg/L PBTK NA 95% Human Human -DTXSID0021414 Clint NA 350.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021414 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021414 Vd NA 984.4 L/kg 1compartment NA NA Rat Human -DTXSID0021414 Days.Css NA 11260 Days PBTK NA NA Rat Human -DTXSID0021414 TK.Half.Life NA 10790 hours 1compartment NA NA Rat Human -DTXSID0021414 Css NA 0.0146 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021414 Css NA 0.05967 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021414 Css NA 2.679 mg/L PBTK NA 50% Rat Human -DTXSID0021414 Css NA 11.05 mg/L PBTK NA 95% Rat Human -DTXSID0021418 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021418 Fup NA 0.9876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021418 Vd NA 0.771 L/kg 1compartment NA NA Human Human +DTXSID0021410 TK.Half.Life NA 5.332 hours 1compartment NA NA Rat Human +DTXSID0021410 Css NA 0.03036 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021410 Css NA 0.1407 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021410 Css NA 0.03108 mg/L PBTK NA 50% Rat Human +DTXSID0021410 Css NA 0.1225 mg/L PBTK NA 95% Rat Human +DTXSID0021414 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021414 Fup 0.0223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021414 Vd NA 2.496 L/kg 1compartment NA NA Human Human +DTXSID0021414 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0021414 TK.Half.Life NA 29.12 hours 1compartment NA NA Human Human +DTXSID0021414 Css NA 1.608 mg/L 3compartmentss NA 50% Human Human +DTXSID0021414 Css NA 11.92 mg/L 3compartmentss NA 95% Human Human +DTXSID0021414 Css NA 1.062 mg/L PBTK NA 50% Human Human +DTXSID0021414 Css NA 7.536 mg/L PBTK NA 95% Human Human +DTXSID0021414 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021414 Fup 0.0223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021414 Vd NA 1.862 L/kg 1compartment NA NA Rat Human +DTXSID0021414 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0021414 TK.Half.Life NA 13.2 hours 1compartment NA NA Rat Human +DTXSID0021414 Css NA 0.3977 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021414 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021414 Css NA 0.259 mg/L PBTK NA 50% Rat Human +DTXSID0021414 Css NA 1.429 mg/L PBTK NA 95% Rat Human +DTXSID0021418 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021418 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021418 Vd NA 0.4046 L/kg 1compartment NA NA Human Human DTXSID0021418 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021418 TK.Half.Life NA 5.056 hours 1compartment NA NA Human Human -DTXSID0021418 Css NA 0.8635 mg/L 3compartmentss NA 50% Human Human -DTXSID0021418 Css NA 4.772 mg/L 3compartmentss NA 95% Human Human -DTXSID0021418 Css NA 0.7218 mg/L PBTK NA 50% Human Human -DTXSID0021418 Css NA 3.163 mg/L PBTK NA 95% Human Human -DTXSID0021418 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021418 Fup NA 0.9876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021418 Vd NA 0.8074 L/kg 1compartment NA NA Rat Human +DTXSID0021418 TK.Half.Life NA 8.029 hours 1compartment NA NA Human Human +DTXSID0021418 Css NA 2.274 mg/L 3compartmentss NA 50% Human Human +DTXSID0021418 Css NA 8.991 mg/L 3compartmentss NA 95% Human Human +DTXSID0021418 Css NA 1.577 mg/L PBTK NA 50% Human Human +DTXSID0021418 Css NA 5.611 mg/L PBTK NA 95% Human Human +DTXSID0021418 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021418 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021418 Vd NA 0.4234 L/kg 1compartment NA NA Rat Human DTXSID0021418 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021418 TK.Half.Life NA 1.803 hours 1compartment NA NA Rat Human -DTXSID0021418 Css NA 0.2221 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021418 Css NA 1.192 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021418 Css NA 0.1805 mg/L PBTK NA 50% Rat Human -DTXSID0021418 Css NA 0.7247 mg/L PBTK NA 95% Rat Human +DTXSID0021418 TK.Half.Life NA 2.863 hours 1compartment NA NA Rat Human +DTXSID0021418 Css NA 0.1479 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021418 Css NA 0.4984 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021418 Css NA 0.1002 mg/L PBTK NA 50% Rat Human +DTXSID0021418 Css NA 0.2987 mg/L PBTK NA 95% Rat Human DTXSID0021460 Clint 209 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0021460 Fup NA 0.0414 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021460 Vd NA 2.332 L/kg 1compartment NA NA Human Human +DTXSID0021460 Fup 0.0616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021460 Vd NA 2.286 L/kg 1compartment NA NA Human Human DTXSID0021460 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021460 TK.Half.Life NA 3.538 hours 1compartment NA NA Human Human -DTXSID0021460 Css NA 0.1052 mg/L 3compartmentss NA 50% Human Human -DTXSID0021460 Css NA 0.8008 mg/L 3compartmentss NA 95% Human Human -DTXSID0021460 Css NA 0.06994 mg/L PBTK NA 50% Human Human -DTXSID0021460 Css NA 0.5158 mg/L PBTK NA 95% Human Human +DTXSID0021460 TK.Half.Life NA 3.002 hours 1compartment NA NA Human Human +DTXSID0021460 Css NA 0.06735 mg/L 3compartmentss NA 50% Human Human +DTXSID0021460 Css NA 0.5059 mg/L 3compartmentss NA 95% Human Human +DTXSID0021460 Css NA 0.04534 mg/L PBTK NA 50% Human Human +DTXSID0021460 Css NA 0.3244 mg/L PBTK NA 95% Human Human DTXSID0021460 Clint 59.5 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0021460 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID0021460 Css NA 0.8198 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0021460 Css NA 6.471 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0021462 Clint NA 2.033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021462 Fup NA 0.2283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021462 Vd NA 1.052 L/kg 1compartment NA NA Human Human -DTXSID0021462 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021462 TK.Half.Life NA 7.918 hours 1compartment NA NA Human Human -DTXSID0021462 Css NA 0.8466 mg/L 3compartmentss NA 50% Human Human -DTXSID0021462 Css NA 4.098 mg/L 3compartmentss NA 95% Human Human -DTXSID0021462 Css NA 0.5978 mg/L PBTK NA 50% Human Human -DTXSID0021462 Css NA 2.642 mg/L PBTK NA 95% Human Human -DTXSID0021462 Clint NA 2.033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021462 Fup NA 0.2283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021462 Vd NA 0.8507 L/kg 1compartment NA NA Rat Human -DTXSID0021462 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021462 TK.Half.Life NA 3.213 hours 1compartment NA NA Rat Human -DTXSID0021462 Css NA 0.3858 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021462 Css NA 1.349 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021462 Css NA 0.2613 mg/L PBTK NA 50% Rat Human -DTXSID0021462 Css NA 0.8078 mg/L PBTK NA 95% Rat Human +DTXSID0021460 Css NA 0.2094 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0021460 Css NA 1.877 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0021462 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021462 Fup 0.0898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021462 Vd NA 9.231 L/kg 1compartment NA NA Human Human +DTXSID0021462 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0021462 TK.Half.Life NA 26.48 hours 1compartment NA NA Human Human +DTXSID0021462 Css NA 0.1691 mg/L 3compartmentss NA 50% Human Human +DTXSID0021462 Css NA 1.567 mg/L 3compartmentss NA 95% Human Human +DTXSID0021462 Css NA 0.2525 mg/L PBTK NA 50% Human Human +DTXSID0021462 Css NA 1.682 mg/L PBTK NA 95% Human Human +DTXSID0021462 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021462 Fup 0.0898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021462 Vd NA 7.527 L/kg 1compartment NA NA Rat Human +DTXSID0021462 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0021462 TK.Half.Life NA 10.21 hours 1compartment NA NA Rat Human +DTXSID0021462 Css NA 0.02043 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021462 Css NA 0.1571 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021462 Css NA 0.032 mg/L PBTK NA 50% Rat Human +DTXSID0021462 Css NA 0.1734 mg/L PBTK NA 95% Rat Human DTXSID0021464 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021464 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021464 Vd NA 0.4262 L/kg 1compartment NA NA Human Human +DTXSID0021464 Vd NA 0.3767 L/kg 1compartment NA NA Human Human DTXSID0021464 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021464 TK.Half.Life NA 5.386 hours 1compartment NA NA Human Human -DTXSID0021464 Css NA 1.507 mg/L 3compartmentss NA 50% Human Human -DTXSID0021464 Css NA 7.333 mg/L 3compartmentss NA 95% Human Human -DTXSID0021464 Css NA 1.071 mg/L PBTK NA 50% Human Human -DTXSID0021464 Css NA 4.537 mg/L PBTK NA 95% Human Human +DTXSID0021464 TK.Half.Life NA 4.731 hours 1compartment NA NA Human Human +DTXSID0021464 Css NA 1.274 mg/L 3compartmentss NA 50% Human Human +DTXSID0021464 Css NA 6.396 mg/L 3compartmentss NA 95% Human Human +DTXSID0021464 Css NA 0.9007 mg/L PBTK NA 50% Human Human +DTXSID0021464 Css NA 3.947 mg/L PBTK NA 95% Human Human DTXSID0021464 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021464 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021464 Vd NA 0.4354 L/kg 1compartment NA NA Rat Human +DTXSID0021464 Vd NA 0.3917 L/kg 1compartment NA NA Rat Human DTXSID0021464 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021464 TK.Half.Life NA 1.921 hours 1compartment NA NA Rat Human -DTXSID0021464 Css NA 0.4239 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021464 Css NA 1.816 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021464 Css NA 0.2857 mg/L PBTK NA 50% Rat Human -DTXSID0021464 Css NA 1.047 mg/L PBTK NA 95% Rat Human +DTXSID0021464 TK.Half.Life NA 1.723 hours 1compartment NA NA Rat Human +DTXSID0021464 Css NA 0.02452 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021464 Css NA 0.17 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021464 Css NA 0.01672 mg/L PBTK NA 50% Rat Human +DTXSID0021464 Css NA 0.1036 mg/L PBTK NA 95% Rat Human DTXSID0021545 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021545 Fup NA 0.4802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021545 Vd NA 0.5282 L/kg 1compartment NA NA Human Human +DTXSID0021545 Vd NA 0.5614 L/kg 1compartment NA NA Human Human DTXSID0021545 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021545 TK.Half.Life NA 7.116 hours 1compartment NA NA Human Human -DTXSID0021545 Css NA 1.508 mg/L 3compartmentss NA 50% Human Human -DTXSID0021545 Css NA 7.203 mg/L 3compartmentss NA 95% Human Human -DTXSID0021545 Css NA 1.142 mg/L PBTK NA 50% Human Human -DTXSID0021545 Css NA 4.575 mg/L PBTK NA 95% Human Human +DTXSID0021545 TK.Half.Life NA 7.563 hours 1compartment NA NA Human Human +DTXSID0021545 Css NA 1.255 mg/L 3compartmentss NA 50% Human Human +DTXSID0021545 Css NA 6.263 mg/L 3compartmentss NA 95% Human Human +DTXSID0021545 Css NA 0.9667 mg/L PBTK NA 50% Human Human +DTXSID0021545 Css NA 3.949 mg/L PBTK NA 95% Human Human DTXSID0021545 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021545 Fup NA 0.4802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021545 Vd NA 0.5403 L/kg 1compartment NA NA Rat Human +DTXSID0021545 Vd NA 0.5709 L/kg 1compartment NA NA Rat Human DTXSID0021545 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021545 TK.Half.Life NA 2.48 hours 1compartment NA NA Rat Human -DTXSID0021545 Css NA 0.41 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021545 Css NA 1.785 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021545 Css NA 0.2966 mg/L PBTK NA 50% Rat Human -DTXSID0021545 Css NA 1.056 mg/L PBTK NA 95% Rat Human +DTXSID0021545 TK.Half.Life NA 2.621 hours 1compartment NA NA Rat Human +DTXSID0021545 Css NA 0.02345 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021545 Css NA 0.1591 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021545 Css NA 0.01745 mg/L PBTK NA 50% Rat Human +DTXSID0021545 Css NA 0.1026 mg/L PBTK NA 95% Rat Human DTXSID0021547 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021547 Fup NA 0.965 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021547 Vd NA 1.232 L/kg 1compartment NA NA Human Human +DTXSID0021547 Vd NA 1.002 L/kg 1compartment NA NA Human Human DTXSID0021547 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021547 TK.Half.Life NA 8.644 hours 1compartment NA NA Human Human -DTXSID0021547 Css NA 0.8188 mg/L 3compartmentss NA 50% Human Human -DTXSID0021547 Css NA 4.944 mg/L 3compartmentss NA 95% Human Human -DTXSID0021547 Css NA 0.7468 mg/L PBTK NA 50% Human Human -DTXSID0021547 Css NA 3.345 mg/L PBTK NA 95% Human Human +DTXSID0021547 TK.Half.Life NA 6.809 hours 1compartment NA NA Human Human +DTXSID0021547 Css NA 0.717 mg/L 3compartmentss NA 50% Human Human +DTXSID0021547 Css NA 4.082 mg/L 3compartmentss NA 95% Human Human +DTXSID0021547 Css NA 0.6348 mg/L PBTK NA 50% Human Human +DTXSID0021547 Css NA 2.749 mg/L PBTK NA 95% Human Human DTXSID0021547 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021547 Fup NA 0.965 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021547 Vd NA 1.177 L/kg 1compartment NA NA Rat Human +DTXSID0021547 Vd NA 0.9999 L/kg 1compartment NA NA Rat Human DTXSID0021547 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021547 TK.Half.Life NA 2.719 hours 1compartment NA NA Rat Human -DTXSID0021547 Css NA 0.2077 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021547 Css NA 1.188 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021547 Css NA 0.1863 mg/L PBTK NA 50% Rat Human -DTXSID0021547 Css NA 0.7471 mg/L PBTK NA 95% Rat Human -DTXSID0021620 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021620 Fup NA 0.9311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021620 Vd NA 1.363 L/kg 1compartment NA NA Human Human -DTXSID0021620 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0021620 TK.Half.Life NA 10.23 hours 1compartment NA NA Human Human -DTXSID0021620 Css NA 0.7969 mg/L 3compartmentss NA 50% Human Human -DTXSID0021620 Css NA 3.045 mg/L 3compartmentss NA 95% Human Human -DTXSID0021620 Css NA 0.743 mg/L PBTK NA 50% Human Human -DTXSID0021620 Css NA 2.244 mg/L PBTK NA 95% Human Human -DTXSID0021620 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021620 Fup NA 0.9311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021620 Vd NA 1.266 L/kg 1compartment NA NA Rat Human -DTXSID0021620 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021620 TK.Half.Life NA 3.055 hours 1compartment NA NA Rat Human -DTXSID0021620 Css NA 0.2028 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021620 Css NA 0.7384 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021620 Css NA 0.187 mg/L PBTK NA 50% Rat Human -DTXSID0021620 Css NA 0.5035 mg/L PBTK NA 95% Rat Human -DTXSID0021626 Clint NA 6.664 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021626 Fup NA 0.2232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021626 Vd NA 1.809 L/kg 1compartment NA NA Human Human +DTXSID0021547 TK.Half.Life NA 2.292 hours 1compartment NA NA Rat Human +DTXSID0021547 Css NA 0.01348 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021547 Css NA 0.09602 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021547 Css NA 0.0114 mg/L PBTK NA 50% Rat Human +DTXSID0021547 Css NA 0.06471 mg/L PBTK NA 95% Rat Human +DTXSID0021626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021626 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021626 Vd NA 1.589 L/kg 1compartment NA NA Human Human DTXSID0021626 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021626 TK.Half.Life NA 7.084 hours 1compartment NA NA Human Human -DTXSID0021626 Css NA 0.3944 mg/L 3compartmentss NA 50% Human Human -DTXSID0021626 Css NA 2.163 mg/L 3compartmentss NA 95% Human Human -DTXSID0021626 Css NA 0.2891 mg/L PBTK NA 50% Human Human -DTXSID0021626 Css NA 1.484 mg/L PBTK NA 95% Human Human -DTXSID0021626 Clint NA 6.664 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021626 Fup NA 0.2232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021626 Vd NA 1.415 L/kg 1compartment NA NA Rat Human +DTXSID0021626 TK.Half.Life NA 3.141 hours 1compartment NA NA Human Human +DTXSID0021626 Css NA 0.1474 mg/L 3compartmentss NA 50% Human Human +DTXSID0021626 Css NA 1.107 mg/L 3compartmentss NA 95% Human Human +DTXSID0021626 Css NA 0.104 mg/L PBTK NA 50% Human Human +DTXSID0021626 Css NA 0.7412 mg/L PBTK NA 95% Human Human +DTXSID0021626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021626 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021626 Vd NA 1.242 L/kg 1compartment NA NA Rat Human DTXSID0021626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021626 TK.Half.Life NA 2.555 hours 1compartment NA NA Rat Human -DTXSID0021626 Css NA 0.2021 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021626 Css NA 0.8368 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021626 Css NA 0.1424 mg/L PBTK NA 50% Rat Human -DTXSID0021626 Css NA 0.5378 mg/L PBTK NA 95% Rat Human +DTXSID0021626 TK.Half.Life NA 1.205 hours 1compartment NA NA Rat Human +DTXSID0021626 Css NA 0.01906 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021626 Css NA 0.1029 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021626 Css NA 0.01336 mg/L PBTK NA 50% Rat Human +DTXSID0021626 Css NA 0.06791 mg/L PBTK NA 95% Rat Human DTXSID0021628 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021628 Fup NA 0.7474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021628 Vd NA 0.7428 L/kg 1compartment NA NA Human Human +DTXSID0021628 Vd NA 0.6418 L/kg 1compartment NA NA Human Human DTXSID0021628 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021628 TK.Half.Life NA 6.448 hours 1compartment NA NA Human Human -DTXSID0021628 Css NA 1.031 mg/L 3compartmentss NA 50% Human Human -DTXSID0021628 Css NA 6.393 mg/L 3compartmentss NA 95% Human Human -DTXSID0021628 Css NA 0.849 mg/L PBTK NA 50% Human Human -DTXSID0021628 Css NA 4.112 mg/L PBTK NA 95% Human Human +DTXSID0021628 TK.Half.Life NA 5.559 hours 1compartment NA NA Human Human +DTXSID0021628 Css NA 0.8976 mg/L 3compartmentss NA 50% Human Human +DTXSID0021628 Css NA 5.828 mg/L 3compartmentss NA 95% Human Human +DTXSID0021628 Css NA 0.7189 mg/L PBTK NA 50% Human Human +DTXSID0021628 Css NA 3.699 mg/L PBTK NA 95% Human Human DTXSID0021628 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021628 Fup NA 0.7474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021628 Vd NA 0.7599 L/kg 1compartment NA NA Rat Human +DTXSID0021628 Vd NA 0.6748 L/kg 1compartment NA NA Rat Human DTXSID0021628 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021628 TK.Half.Life NA 2.243 hours 1compartment NA NA Rat Human -DTXSID0021628 Css NA 0.268 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021628 Css NA 1.668 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021628 Css NA 0.2127 mg/L PBTK NA 50% Rat Human -DTXSID0021628 Css NA 0.9916 mg/L PBTK NA 95% Rat Human -DTXSID0021709 Clint NA 0.9745 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021709 Fup NA 0.9319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021709 Vd NA 1.115 L/kg 1compartment NA NA Human Human +DTXSID0021628 TK.Half.Life NA 1.991 hours 1compartment NA NA Rat Human +DTXSID0021628 Css NA 0.0172 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021628 Css NA 0.1381 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021628 Css NA 0.0132 mg/L PBTK NA 50% Rat Human +DTXSID0021628 Css NA 0.08793 mg/L PBTK NA 95% Rat Human +DTXSID0021709 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021709 Fup 0.422 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021709 Vd NA 0.6945 L/kg 1compartment NA NA Human Human DTXSID0021709 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021709 TK.Half.Life NA 3.265 hours 1compartment NA NA Human Human -DTXSID0021709 Css NA 0.3116 mg/L 3compartmentss NA 50% Human Human -DTXSID0021709 Css NA 1.365 mg/L 3compartmentss NA 95% Human Human -DTXSID0021709 Css NA 0.2787 mg/L PBTK NA 50% Human Human -DTXSID0021709 Css NA 1.008 mg/L PBTK NA 95% Human Human -DTXSID0021709 Clint NA 0.9745 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021709 Fup NA 0.9319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021709 Vd NA 1.083 L/kg 1compartment NA NA Rat Human +DTXSID0021709 TK.Half.Life NA 0.7562 hours 1compartment NA NA Human Human +DTXSID0021709 Css NA 0.04577 mg/L 3compartmentss NA 50% Human Human +DTXSID0021709 Css NA 0.3773 mg/L 3compartmentss NA 95% Human Human +DTXSID0021709 Css NA 0.03468 mg/L PBTK NA 50% Human Human +DTXSID0021709 Css NA 0.2565 mg/L PBTK NA 95% Human Human +DTXSID0021709 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021709 Fup 0.422 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021709 Vd NA 0.6705 L/kg 1compartment NA NA Rat Human DTXSID0021709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021709 TK.Half.Life NA 1.492 hours 1compartment NA NA Rat Human -DTXSID0021709 Css NA 0.1163 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021709 Css NA 0.4275 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021709 Css NA 0.1037 mg/L PBTK NA 50% Rat Human -DTXSID0021709 Css NA 0.2926 mg/L PBTK NA 95% Rat Human +DTXSID0021709 TK.Half.Life NA 0.3737 hours 1compartment NA NA Rat Human +DTXSID0021709 Css NA 0.005662 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021709 Css NA 0.03586 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021709 Css NA 0.004288 mg/L PBTK NA 50% Rat Human +DTXSID0021709 Css NA 0.02412 mg/L PBTK NA 95% Rat Human DTXSID0021751 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021751 Fup NA 0.523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021751 Vd NA 0.7182 L/kg 1compartment NA NA Human Human DTXSID0021751 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0021751 TK.Half.Life NA 8.969 hours 1compartment NA NA Human Human -DTXSID0021751 Css NA 1.379 mg/L 3compartmentss NA 50% Human Human -DTXSID0021751 Css NA 7.664 mg/L 3compartmentss NA 95% Human Human -DTXSID0021751 Css NA 1.089 mg/L PBTK NA 50% Human Human -DTXSID0021751 Css NA 4.908 mg/L PBTK NA 95% Human Human +DTXSID0021751 Css NA 1.163 mg/L 3compartmentss NA 50% Human Human +DTXSID0021751 Css NA 6.717 mg/L 3compartmentss NA 95% Human Human +DTXSID0021751 Css NA 0.9224 mg/L PBTK NA 50% Human Human +DTXSID0021751 Css NA 4.269 mg/L PBTK NA 95% Human Human DTXSID0021751 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021751 Fup NA 0.523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021751 Vd NA 0.7075 L/kg 1compartment NA NA Rat Human DTXSID0021751 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0021751 TK.Half.Life NA 2.99 hours 1compartment NA NA Rat Human -DTXSID0021751 Css NA 0.3677 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021751 Css NA 1.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021751 Css NA 0.2782 mg/L PBTK NA 50% Rat Human -DTXSID0021751 Css NA 1.122 mg/L PBTK NA 95% Rat Human -DTXSID0021757 Clint NA 7.296 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021757 Fup NA 0.6618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021757 Vd NA 1.678 L/kg 1compartment NA NA Human Human +DTXSID0021751 Css NA 0.02186 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021751 Css NA 0.164 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021751 Css NA 0.01673 mg/L PBTK NA 50% Rat Human +DTXSID0021751 Css NA 0.1077 mg/L PBTK NA 95% Rat Human +DTXSID0021757 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021757 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021757 Vd NA 1.455 L/kg 1compartment NA NA Human Human DTXSID0021757 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0021757 TK.Half.Life NA 2.353 hours 1compartment NA NA Human Human -DTXSID0021757 Css NA 0.09677 mg/L 3compartmentss NA 50% Human Human -DTXSID0021757 Css NA 0.8557 mg/L 3compartmentss NA 95% Human Human -DTXSID0021757 Css NA 0.08527 mg/L PBTK NA 50% Human Human -DTXSID0021757 Css NA 0.6263 mg/L PBTK NA 95% Human Human -DTXSID0021757 Clint NA 7.296 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021757 Fup NA 0.6618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021757 Vd NA 1.431 L/kg 1compartment NA NA Rat Human +DTXSID0021757 TK.Half.Life NA 1.457 hours 1compartment NA NA Human Human +DTXSID0021757 Css NA 0.04056 mg/L 3compartmentss NA 50% Human Human +DTXSID0021757 Css NA 0.3636 mg/L 3compartmentss NA 95% Human Human +DTXSID0021757 Css NA 0.0337 mg/L PBTK NA 50% Human Human +DTXSID0021757 Css NA 0.2636 mg/L PBTK NA 95% Human Human +DTXSID0021757 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021757 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021757 Vd NA 1.237 L/kg 1compartment NA NA Rat Human DTXSID0021757 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021757 TK.Half.Life NA 0.9743 hours 1compartment NA NA Rat Human -DTXSID0021757 Css NA 0.04726 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021757 Css NA 0.355 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021757 Css NA 0.041 mg/L PBTK NA 50% Rat Human -DTXSID0021757 Css NA 0.2334 mg/L PBTK NA 95% Rat Human +DTXSID0021757 TK.Half.Life NA 0.5986 hours 1compartment NA NA Rat Human +DTXSID0021757 Css NA 0.004982 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021757 Css NA 0.03569 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021757 Css NA 0.004203 mg/L PBTK NA 50% Rat Human +DTXSID0021757 Css NA 0.02533 mg/L PBTK NA 95% Rat Human DTXSID0021759 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021759 Fup NA 0.8354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0021759 Vd NA 1.098 L/kg 1compartment NA NA Human Human DTXSID0021759 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0021759 TK.Half.Life NA 8.802 hours 1compartment NA NA Human Human -DTXSID0021759 Css NA 0.9078 mg/L 3compartmentss NA 50% Human Human -DTXSID0021759 Css NA 5.626 mg/L 3compartmentss NA 95% Human Human -DTXSID0021759 Css NA 0.8084 mg/L PBTK NA 50% Human Human -DTXSID0021759 Css NA 3.714 mg/L PBTK NA 95% Human Human +DTXSID0021759 Css NA 0.7745 mg/L 3compartmentss NA 50% Human Human +DTXSID0021759 Css NA 4.956 mg/L 3compartmentss NA 95% Human Human +DTXSID0021759 Css NA 0.6894 mg/L PBTK NA 50% Human Human +DTXSID0021759 Css NA 3.274 mg/L PBTK NA 95% Human Human DTXSID0021759 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021759 Fup NA 0.8354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0021759 Vd NA 1.054 L/kg 1compartment NA NA Rat Human DTXSID0021759 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0021759 TK.Half.Life NA 2.804 hours 1compartment NA NA Rat Human -DTXSID0021759 Css NA 0.2324 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021759 Css NA 1.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021759 Css NA 0.2012 mg/L PBTK NA 50% Rat Human -DTXSID0021759 Css NA 0.8792 mg/L PBTK NA 95% Rat Human +DTXSID0021759 Css NA 0.01428 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021759 Css NA 0.1116 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021759 Css NA 0.01231 mg/L PBTK NA 50% Rat Human +DTXSID0021759 Css NA 0.07513 mg/L PBTK NA 95% Rat Human +DTXSID0021830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021830 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021830 Vd NA 0.792 L/kg 1compartment NA NA Human Human +DTXSID0021830 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0021830 TK.Half.Life NA 0.8202 hours 1compartment NA NA Human Human +DTXSID0021830 Css NA 0.04112 mg/L 3compartmentss NA 50% Human Human +DTXSID0021830 Css NA 0.3805 mg/L 3compartmentss NA 95% Human Human +DTXSID0021830 Css NA 0.03196 mg/L PBTK NA 50% Human Human +DTXSID0021830 Css NA 0.2627 mg/L PBTK NA 95% Human Human +DTXSID0021830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021830 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021830 Vd NA 0.7512 L/kg 1compartment NA NA Rat Human +DTXSID0021830 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0021830 TK.Half.Life NA 0.3947 hours 1compartment NA NA Rat Human +DTXSID0021830 Css NA 0.005108 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021830 Css NA 0.03482 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021830 Css NA 0.003982 mg/L PBTK NA 50% Rat Human +DTXSID0021830 Css NA 0.02357 mg/L PBTK NA 95% Rat Human DTXSID0021834 Clint 14 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0021834 Fup 0.141 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0021834 Vd NA 0.5276 L/kg 1compartment NA NA Human Human DTXSID0021834 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0021834 TK.Half.Life NA 1.419 hours 1compartment NA NA Human Human -DTXSID0021834 Css NA 0.2392 mg/L 3compartmentss NA 50% Human Human -DTXSID0021834 Css NA 1.486 mg/L 3compartmentss NA 95% Human Human -DTXSID0021834 Css NA 0.1555 mg/L PBTK NA 50% Human Human -DTXSID0021834 Css NA 0.9385 mg/L PBTK NA 95% Human Human +DTXSID0021834 Css NA 0.2346 mg/L 3compartmentss NA 50% Human Human +DTXSID0021834 Css NA 1.493 mg/L 3compartmentss NA 95% Human Human +DTXSID0021834 Css NA 0.1512 mg/L PBTK NA 50% Human Human +DTXSID0021834 Css NA 0.9121 mg/L PBTK NA 95% Human Human DTXSID0021834 Clint 14 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0021834 Fup 0.141 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0021834 Vd NA 0.455 L/kg 1compartment NA NA Rat Human DTXSID0021834 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0021834 TK.Half.Life NA 0.7138 hours 1compartment NA NA Rat Human -DTXSID0021834 Css NA 0.1293 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021834 Css NA 0.572 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021834 Css NA 0.07959 mg/L PBTK NA 50% Rat Human -DTXSID0021834 Css NA 0.3367 mg/L PBTK NA 95% Rat Human -DTXSID0021836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021836 Fup NA 0.4409 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021836 Vd NA 1.125 L/kg 1compartment NA NA Human Human -DTXSID0021836 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0021836 TK.Half.Life NA 18.07 hours 1compartment NA NA Human Human -DTXSID0021836 Css NA 1.676 mg/L 3compartmentss NA 50% Human Human -DTXSID0021836 Css NA 7.573 mg/L 3compartmentss NA 95% Human Human -DTXSID0021836 Css NA 1.345 mg/L PBTK NA 50% Human Human -DTXSID0021836 Css NA 5.01 mg/L PBTK NA 95% Human Human -DTXSID0021836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021836 Fup NA 0.4409 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021836 Vd NA 0.9877 L/kg 1compartment NA NA Rat Human -DTXSID0021836 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021836 TK.Half.Life NA 5.048 hours 1compartment NA NA Rat Human -DTXSID0021836 Css NA 0.4516 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021836 Css NA 1.773 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021836 Css NA 0.3498 mg/L PBTK NA 50% Rat Human -DTXSID0021836 Css NA 1.091 mg/L PBTK NA 95% Rat Human -DTXSID0021915 Clint NA 27.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021915 Fup NA 0.0711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0021915 Vd NA 2.785 L/kg 1compartment NA NA Human Human -DTXSID0021915 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0021915 TK.Half.Life NA 17.36 hours 1compartment NA NA Human Human -DTXSID0021915 Css NA 0.718 mg/L 3compartmentss NA 50% Human Human -DTXSID0021915 Css NA 4.548 mg/L 3compartmentss NA 95% Human Human -DTXSID0021915 Css NA 0.4956 mg/L PBTK NA 50% Human Human -DTXSID0021915 Css NA 3.023 mg/L PBTK NA 95% Human Human -DTXSID0021915 Clint NA 27.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021915 Fup NA 0.0711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0021915 Vd NA 2.091 L/kg 1compartment NA NA Rat Human -DTXSID0021915 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0021915 TK.Half.Life NA 3.683 hours 1compartment NA NA Rat Human -DTXSID0021915 Css NA 0.4014 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021915 Css NA 2.028 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021915 Css NA 0.2644 mg/L PBTK NA 50% Rat Human -DTXSID0021915 Css NA 1.295 mg/L PBTK NA 95% Rat Human +DTXSID0021834 Css NA 0.02948 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021834 Css NA 0.1301 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021834 Css NA 0.01875 mg/L PBTK NA 50% Rat Human +DTXSID0021834 Css NA 0.08016 mg/L PBTK NA 95% Rat Human +DTXSID0021915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021915 Fup 0.0878 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0021915 Vd NA 2.935 L/kg 1compartment NA NA Human Human +DTXSID0021915 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0021915 TK.Half.Life NA 25.83 hours 1compartment NA NA Human Human +DTXSID0021915 Css NA 1.012 mg/L 3compartmentss NA 50% Human Human +DTXSID0021915 Css NA 6.581 mg/L 3compartmentss NA 95% Human Human +DTXSID0021915 Css NA 0.7004 mg/L PBTK NA 50% Human Human +DTXSID0021915 Css NA 4.432 mg/L PBTK NA 95% Human Human +DTXSID0021915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021915 Fup 0.0878 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0021915 Vd NA 2.205 L/kg 1compartment NA NA Rat Human +DTXSID0021915 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0021915 TK.Half.Life NA 4.671 hours 1compartment NA NA Rat Human +DTXSID0021915 Css NA 0.1294 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021915 Css NA 0.731 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021915 Css NA 0.08916 mg/L PBTK NA 50% Rat Human +DTXSID0021915 Css NA 0.4938 mg/L PBTK NA 95% Rat Human DTXSID0021961 Clint 9.134 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0021961 Fup 0.06543 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0021961 Vd NA 1.864 L/kg 1compartment NA NA Human Human DTXSID0021961 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID0021961 TK.Half.Life NA 16.3 hours 1compartment NA NA Human Human -DTXSID0021961 Css NA 1.213 mg/L 3compartmentss NA 50% Human Human -DTXSID0021961 Css NA 7.469 mg/L 3compartmentss NA 95% Human Human -DTXSID0021961 Css NA 0.7964 mg/L PBTK NA 50% Human Human -DTXSID0021961 Css NA 4.734 mg/L PBTK NA 95% Human Human +DTXSID0021961 Css NA 1.152 mg/L 3compartmentss NA 50% Human Human +DTXSID0021961 Css NA 7.497 mg/L 3compartmentss NA 95% Human Human +DTXSID0021961 Css NA 0.7582 mg/L PBTK NA 50% Human Human +DTXSID0021961 Css NA 4.729 mg/L PBTK NA 95% Human Human DTXSID0021961 Clint 56.9 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID0021961 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID0021961 Css NA 1.002 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0021961 Css NA 8.341 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0021961 Css 0.0042 0.2406 mg/L 3compartmentss National Toxicology Program 50% Rat Rat +DTXSID0021961 Css 0.0042 2.194 mg/L 3compartmentss National Toxicology Program 95% Rat Rat DTXSID0021969 Clint 234 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0021969 Fup 0.322 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0021969 Vd NA 0.6224 L/kg 1compartment NA NA Human Human DTXSID0021969 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0021969 TK.Half.Life NA 0.5082 hours 1compartment NA NA Human Human -DTXSID0021969 Css NA 0.005813 mg/L 3compartmentss NA 50% Human Human -DTXSID0021969 Css NA 0.03877 mg/L 3compartmentss NA 95% Human Human -DTXSID0021969 Css NA 0.004136 mg/L PBTK NA 50% Human Human -DTXSID0021969 Css NA 0.02665 mg/L PBTK NA 95% Human Human +DTXSID0021969 Css NA 0.00406 mg/L 3compartmentss NA 50% Human Human +DTXSID0021969 Css NA 0.03512 mg/L 3compartmentss NA 95% Human Human +DTXSID0021969 Css NA 0.0029 mg/L PBTK NA 50% Human Human +DTXSID0021969 Css NA 0.02414 mg/L PBTK NA 95% Human Human DTXSID0021969 Clint 234 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0021969 Fup 0.322 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0021969 Vd NA 0.5756 L/kg 1compartment NA NA Rat Human DTXSID0021969 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0021969 TK.Half.Life NA 0.2106 hours 1compartment NA NA Rat Human -DTXSID0021969 Css NA 0.00323 mg/L 3compartmentss NA 50% Rat Human -DTXSID0021969 Css NA 0.01656 mg/L 3compartmentss NA 95% Rat Human -DTXSID0021969 Css NA 0.002218 mg/L PBTK NA 50% Rat Human -DTXSID0021969 Css NA 0.01109 mg/L PBTK NA 95% Rat Human -DTXSID0022010 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022010 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022010 Vd NA 46.83 L/kg 1compartment NA NA Human Human -DTXSID0022010 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID0022010 TK.Half.Life NA 2236000 hours 1compartment NA NA Human Human -DTXSID0022010 Css NA 718.2 mg/L 3compartmentss NA 50% Human Human -DTXSID0022010 Css NA 1801 mg/L 3compartmentss NA 95% Human Human -DTXSID0022010 Css NA 3682 mg/L PBTK NA 50% Human Human -DTXSID0022010 Css NA 7815 mg/L PBTK NA 95% Human Human -DTXSID0022010 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022010 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022010 Vd NA 39.38 L/kg 1compartment NA NA Rat Human -DTXSID0022010 Days.Css NA 13780 Days PBTK NA NA Rat Human -DTXSID0022010 TK.Half.Life NA 158400 hours 1compartment NA NA Rat Human -DTXSID0022010 Css NA 177.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022010 Css NA 308.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022010 Css NA 989.1 mg/L PBTK NA 50% Rat Human -DTXSID0022010 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID0022012 Clint NA 44.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022012 Fup NA 0.5879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022012 Vd NA 1.214 L/kg 1compartment NA NA Human Human +DTXSID0021969 Css NA 0.000556 mg/L 3compartmentss NA 50% Rat Human +DTXSID0021969 Css NA 0.003839 mg/L 3compartmentss NA 95% Rat Human +DTXSID0021969 Css NA 0.0004004 mg/L PBTK NA 50% Rat Human +DTXSID0021969 Css NA 0.002654 mg/L PBTK NA 95% Rat Human +DTXSID0022012 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022012 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022012 Vd NA 0.8832 L/kg 1compartment NA NA Human Human DTXSID0022012 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022012 TK.Half.Life NA 0.9181 hours 1compartment NA NA Human Human -DTXSID0022012 Css NA 0.01804 mg/L 3compartmentss NA 50% Human Human -DTXSID0022012 Css NA 0.1986 mg/L 3compartmentss NA 95% Human Human -DTXSID0022012 Css NA 0.01527 mg/L PBTK NA 50% Human Human -DTXSID0022012 Css NA 0.1379 mg/L PBTK NA 95% Human Human -DTXSID0022012 Clint NA 44.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022012 Fup NA 0.5879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022012 Vd NA 1.087 L/kg 1compartment NA NA Rat Human +DTXSID0022012 TK.Half.Life NA 1.079 hours 1compartment NA NA Human Human +DTXSID0022012 Css NA 0.06027 mg/L 3compartmentss NA 50% Human Human +DTXSID0022012 Css NA 0.4463 mg/L 3compartmentss NA 95% Human Human +DTXSID0022012 Css NA 0.04466 mg/L PBTK NA 50% Human Human +DTXSID0022012 Css NA 0.3036 mg/L PBTK NA 95% Human Human +DTXSID0022012 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022012 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022012 Vd NA 0.7866 L/kg 1compartment NA NA Rat Human DTXSID0022012 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022012 TK.Half.Life NA 0.3838 hours 1compartment NA NA Rat Human -DTXSID0022012 Css NA 0.009536 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022012 Css NA 0.09203 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022012 Css NA 0.007879 mg/L PBTK NA 50% Rat Human -DTXSID0022012 Css NA 0.06141 mg/L PBTK NA 95% Rat Human -DTXSID0022014 Clint NA 359.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022014 Fup NA 0.4703 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022014 Vd NA 1.755 L/kg 1compartment NA NA Human Human +DTXSID0022012 TK.Half.Life NA 0.4976 hours 1compartment NA NA Rat Human +DTXSID0022012 Css NA 0.007318 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022012 Css NA 0.04519 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022012 Css NA 0.005448 mg/L PBTK NA 50% Rat Human +DTXSID0022012 Css NA 0.02997 mg/L PBTK NA 95% Rat Human +DTXSID0022014 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022014 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022014 Vd NA 1.438 L/kg 1compartment NA NA Human Human DTXSID0022014 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022014 TK.Half.Life NA 1.189 hours 1compartment NA NA Human Human -DTXSID0022014 Css NA 0.00329 mg/L 3compartmentss NA 50% Human Human -DTXSID0022014 Css NA 0.02784 mg/L 3compartmentss NA 95% Human Human -DTXSID0022014 Css NA 0.002705 mg/L PBTK NA 50% Human Human -DTXSID0022014 Css NA 0.01997 mg/L PBTK NA 95% Human Human -DTXSID0022014 Clint NA 359.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022014 Fup NA 0.4703 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022014 Vd NA 1.439 L/kg 1compartment NA NA Rat Human +DTXSID0022014 TK.Half.Life NA 1.918 hours 1compartment NA NA Human Human +DTXSID0022014 Css NA 0.07172 mg/L 3compartmentss NA 50% Human Human +DTXSID0022014 Css NA 0.5391 mg/L 3compartmentss NA 95% Human Human +DTXSID0022014 Css NA 0.05446 mg/L PBTK NA 50% Human Human +DTXSID0022014 Css NA 0.3737 mg/L PBTK NA 95% Human Human +DTXSID0022014 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022014 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022014 Vd NA 1.173 L/kg 1compartment NA NA Rat Human DTXSID0022014 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022014 TK.Half.Life NA 0.4229 hours 1compartment NA NA Rat Human -DTXSID0022014 Css NA 0.001763 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022014 Css NA 0.01296 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022014 Css NA 0.001418 mg/L PBTK NA 50% Rat Human -DTXSID0022014 Css NA 0.00911 mg/L PBTK NA 95% Rat Human +DTXSID0022014 TK.Half.Life NA 0.7721 hours 1compartment NA NA Rat Human +DTXSID0022014 Css NA 0.008984 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022014 Css NA 0.05179 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022014 Css NA 0.006827 mg/L PBTK NA 50% Rat Human +DTXSID0022014 Css NA 0.03567 mg/L PBTK NA 95% Rat Human DTXSID0022016 Clint NA 6.988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0022016 Fup NA 0.7711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022016 Vd NA 2.121 L/kg 1compartment NA NA Human Human +DTXSID0022016 Vd NA 2.093 L/kg 1compartment NA NA Human Human DTXSID0022016 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022016 TK.Half.Life NA 2.267 hours 1compartment NA NA Human Human -DTXSID0022016 Css NA 0.0698 mg/L 3compartmentss NA 50% Human Human -DTXSID0022016 Css NA 0.6631 mg/L 3compartmentss NA 95% Human Human -DTXSID0022016 Css NA 0.07135 mg/L PBTK NA 50% Human Human -DTXSID0022016 Css NA 0.494 mg/L PBTK NA 95% Human Human +DTXSID0022016 TK.Half.Life NA 2.24 hours 1compartment NA NA Human Human +DTXSID0022016 Css NA 0.05568 mg/L 3compartmentss NA 50% Human Human +DTXSID0022016 Css NA 0.5648 mg/L 3compartmentss NA 95% Human Human +DTXSID0022016 Css NA 0.05659 mg/L PBTK NA 50% Human Human +DTXSID0022016 Css NA 0.4288 mg/L PBTK NA 95% Human Human DTXSID0022016 Clint NA 6.988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0022016 Fup NA 0.7711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022016 Vd NA 2.152 L/kg 1compartment NA NA Rat Human +DTXSID0022016 Vd NA 2.125 L/kg 1compartment NA NA Rat Human DTXSID0022016 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022016 TK.Half.Life NA 1.249 hours 1compartment NA NA Rat Human -DTXSID0022016 Css NA 0.03316 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022016 Css NA 0.2904 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022016 Css NA 0.03378 mg/L PBTK NA 50% Rat Human -DTXSID0022016 Css NA 0.1975 mg/L PBTK NA 95% Rat Human -DTXSID0022060 Clint NA 16.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022060 Fup NA 0.6074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022060 Vd NA 1.386 L/kg 1compartment NA NA Human Human +DTXSID0022016 TK.Half.Life NA 1.235 hours 1compartment NA NA Rat Human +DTXSID0022016 Css NA 0.00187 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022016 Css NA 0.0223 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022016 Css NA 0.001899 mg/L PBTK NA 50% Rat Human +DTXSID0022016 Css NA 0.017 mg/L PBTK NA 95% Rat Human +DTXSID0022060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022060 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022060 Vd NA 0.7973 L/kg 1compartment NA NA Human Human DTXSID0022060 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022060 TK.Half.Life NA 1.37 hours 1compartment NA NA Human Human -DTXSID0022060 Css NA 0.04732 mg/L 3compartmentss NA 50% Human Human -DTXSID0022060 Css NA 0.4487 mg/L 3compartmentss NA 95% Human Human -DTXSID0022060 Css NA 0.03972 mg/L PBTK NA 50% Human Human -DTXSID0022060 Css NA 0.3188 mg/L PBTK NA 95% Human Human -DTXSID0022060 Clint NA 16.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022060 Fup NA 0.6074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022060 Vd NA 1.193 L/kg 1compartment NA NA Rat Human +DTXSID0022060 TK.Half.Life NA 1.246 hours 1compartment NA NA Human Human +DTXSID0022060 Css NA 0.09798 mg/L 3compartmentss NA 50% Human Human +DTXSID0022060 Css NA 0.6661 mg/L 3compartmentss NA 95% Human Human +DTXSID0022060 Css NA 0.06796 mg/L PBTK NA 50% Human Human +DTXSID0022060 Css NA 0.4387 mg/L PBTK NA 95% Human Human +DTXSID0022060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022060 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022060 Vd NA 0.6793 L/kg 1compartment NA NA Rat Human DTXSID0022060 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022060 TK.Half.Life NA 0.5733 hours 1compartment NA NA Rat Human -DTXSID0022060 Css NA 0.02434 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022060 Css NA 0.2036 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022060 Css NA 0.02004 mg/L PBTK NA 50% Rat Human -DTXSID0022060 Css NA 0.1303 mg/L PBTK NA 95% Rat Human +DTXSID0022060 TK.Half.Life NA 0.5691 hours 1compartment NA NA Rat Human +DTXSID0022060 Css NA 0.01226 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022060 Css NA 0.06627 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022060 Css NA 0.00836 mg/L PBTK NA 50% Rat Human +DTXSID0022060 Css NA 0.0429 mg/L PBTK NA 95% Rat Human DTXSID00220983 Clint 64.57 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID00220983 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID00220983 Vd NA 0.6232 L/kg 1compartment NA NA Human Human +DTXSID00220983 Vd NA 0.4067 L/kg 1compartment NA NA Human Human DTXSID00220983 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID00220983 TK.Half.Life NA 1.005 hours 1compartment NA NA Human Human -DTXSID00220983 Css NA 0.1274 mg/L 3compartmentss NA 50% Human Human -DTXSID00220983 Css NA 1.062 mg/L 3compartmentss NA 95% Human Human -DTXSID00220983 Css NA 0.07934 mg/L PBTK NA 50% Human Human -DTXSID00220983 Css NA 0.6418 mg/L PBTK NA 95% Human Human +DTXSID00220983 TK.Half.Life NA 0.6652 hours 1compartment NA NA Human Human +DTXSID00220983 Css NA 0.1237 mg/L 3compartmentss NA 50% Human Human +DTXSID00220983 Css NA 1.055 mg/L 3compartmentss NA 95% Human Human +DTXSID00220983 Css NA 0.07654 mg/L PBTK NA 50% Human Human +DTXSID00220983 Css NA 0.6443 mg/L PBTK NA 95% Human Human DTXSID00220983 Clint 64.57 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID00220983 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID00220983 Vd NA 0.5334 L/kg 1compartment NA NA Rat Human +DTXSID00220983 Vd NA 0.3781 L/kg 1compartment NA NA Rat Human DTXSID00220983 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID00220983 TK.Half.Life NA 0.4668 hours 1compartment NA NA Rat Human -DTXSID00220983 Css NA 0.07277 mg/L 3compartmentss NA 50% Rat Human -DTXSID00220983 Css NA 0.492 mg/L 3compartmentss NA 95% Rat Human -DTXSID00220983 Css NA 0.04279 mg/L PBTK NA 50% Rat Human -DTXSID00220983 Css NA 0.2792 mg/L PBTK NA 95% Rat Human -DTXSID0022220 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022220 Fup NA 0.0066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022220 Vd NA 0.936 L/kg 1compartment NA NA Human Human -DTXSID0022220 Days.Css NA 281 Days PBTK NA NA Human Human -DTXSID0022220 TK.Half.Life NA 1067 hours 1compartment NA NA Human Human -DTXSID0022220 Css NA 189.2 mg/L 3compartmentss NA 50% Human Human -DTXSID0022220 Css NA 1068 mg/L 3compartmentss NA 95% Human Human -DTXSID0022220 Css NA 113.7 mg/L PBTK NA 50% Human Human -DTXSID0022220 Css NA 628.6 mg/L PBTK NA 95% Human Human -DTXSID0022220 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022220 Fup NA 0.0066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022220 Vd NA 0.6875 L/kg 1compartment NA NA Rat Human -DTXSID0022220 Days.Css NA 65 Days PBTK NA NA Rat Human -DTXSID0022220 TK.Half.Life NA 238.6 hours 1compartment NA NA Rat Human -DTXSID0022220 Css NA 53.88 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022220 Css NA 269.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022220 Css NA 30.18 mg/L PBTK NA 50% Rat Human -DTXSID0022220 Css NA 146.4 mg/L PBTK NA 95% Rat Human -DTXSID0022301 Clint NA 193.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022301 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022301 Vd NA 4.207 L/kg 1compartment NA NA Human Human -DTXSID0022301 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0022301 TK.Half.Life NA 17.26 hours 1compartment NA NA Human Human -DTXSID0022301 Css NA 0.3696 mg/L 3compartmentss NA 50% Human Human -DTXSID0022301 Css NA 2.062 mg/L 3compartmentss NA 95% Human Human -DTXSID0022301 Css NA 0.2806 mg/L PBTK NA 50% Human Human -DTXSID0022301 Css NA 1.525 mg/L PBTK NA 95% Human Human -DTXSID0022301 Clint NA 193.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022301 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022301 Vd NA 3.189 L/kg 1compartment NA NA Rat Human -DTXSID0022301 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022301 TK.Half.Life NA 2.974 hours 1compartment NA NA Rat Human -DTXSID0022301 Css NA 0.2071 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022301 Css NA 0.8817 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022301 Css NA 0.1514 mg/L PBTK NA 50% Rat Human -DTXSID0022301 Css NA 0.6429 mg/L PBTK NA 95% Rat Human -DTXSID0022307 Clint NA 6.815 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022307 Fup NA 0.1393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022307 Vd NA 2.532 L/kg 1compartment NA NA Human Human -DTXSID0022307 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0022307 TK.Half.Life NA 23.63 hours 1compartment NA NA Human Human -DTXSID0022307 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID0022307 Css NA 6.59 mg/L 3compartmentss NA 95% Human Human -DTXSID0022307 Css NA 0.7995 mg/L PBTK NA 50% Human Human -DTXSID0022307 Css NA 4.394 mg/L PBTK NA 95% Human Human -DTXSID0022307 Clint NA 6.815 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022307 Fup NA 0.1393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022307 Vd NA 1.916 L/kg 1compartment NA NA Rat Human -DTXSID0022307 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0022307 TK.Half.Life NA 5.747 hours 1compartment NA NA Rat Human -DTXSID0022307 Css NA 0.6148 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022307 Css NA 2.542 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022307 Css NA 0.411 mg/L PBTK NA 50% Rat Human -DTXSID0022307 Css NA 1.602 mg/L PBTK NA 95% Rat Human +DTXSID00220983 TK.Half.Life NA 0.3388 hours 1compartment NA NA Rat Human +DTXSID00220983 Css NA 0.01661 mg/L 3compartmentss NA 50% Rat Human +DTXSID00220983 Css NA 0.1132 mg/L 3compartmentss NA 95% Rat Human +DTXSID00220983 Css NA 0.009914 mg/L PBTK NA 50% Rat Human +DTXSID00220983 Css NA 0.06599 mg/L PBTK NA 95% Rat Human +DTXSID0022191 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022191 Fup 0.544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022191 Vd NA 1.548 L/kg 1compartment NA NA Human Human +DTXSID0022191 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0022191 TK.Half.Life NA 1.497 hours 1compartment NA NA Human Human +DTXSID0022191 Css NA 0.0389 mg/L 3compartmentss NA 50% Human Human +DTXSID0022191 Css NA 0.3621 mg/L 3compartmentss NA 95% Human Human +DTXSID0022191 Css NA 0.03263 mg/L PBTK NA 50% Human Human +DTXSID0022191 Css NA 0.2644 mg/L PBTK NA 95% Human Human +DTXSID0022191 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022191 Fup 0.544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022191 Vd NA 1.312 L/kg 1compartment NA NA Rat Human +DTXSID0022191 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0022191 TK.Half.Life NA 0.6059 hours 1compartment NA NA Rat Human +DTXSID0022191 Css NA 0.004686 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022191 Css NA 0.03837 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022191 Css NA 0.00401 mg/L PBTK NA 50% Rat Human +DTXSID0022191 Css NA 0.02669 mg/L PBTK NA 95% Rat Human +DTXSID0022220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022220 Fup 0.00941 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022220 Vd NA 1.114 L/kg 1compartment NA NA Human Human +DTXSID0022220 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0022220 TK.Half.Life NA 17.51 hours 1compartment NA NA Human Human +DTXSID0022220 Css NA 2.622 mg/L 3compartmentss NA 50% Human Human +DTXSID0022220 Css NA 24.7 mg/L 3compartmentss NA 95% Human Human +DTXSID0022220 Css NA 1.59 mg/L PBTK NA 50% Human Human +DTXSID0022220 Css NA 14.66 mg/L PBTK NA 95% Human Human +DTXSID0022220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022220 Fup 0.00941 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022220 Vd NA 0.819 L/kg 1compartment NA NA Rat Human +DTXSID0022220 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0022220 TK.Half.Life NA 7.474 hours 1compartment NA NA Rat Human +DTXSID0022220 Css NA 0.3462 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022220 Css NA 2.681 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022220 Css NA 0.2041 mg/L PBTK NA 50% Rat Human +DTXSID0022220 Css NA 1.532 mg/L PBTK NA 95% Rat Human +DTXSID0022301 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022301 Fup 0.00575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022301 Vd NA 4.212 L/kg 1compartment NA NA Human Human +DTXSID0022301 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID0022301 TK.Half.Life NA 128.8 hours 1compartment NA NA Human Human +DTXSID0022301 Css NA 3.199 mg/L 3compartmentss NA 50% Human Human +DTXSID0022301 Css NA 18.62 mg/L 3compartmentss NA 95% Human Human +DTXSID0022301 Css NA 2.418 mg/L PBTK NA 50% Human Human +DTXSID0022301 Css NA 13.89 mg/L PBTK NA 95% Human Human +DTXSID0022301 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022301 Fup 0.00575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022301 Vd NA 3.193 L/kg 1compartment NA NA Rat Human +DTXSID0022301 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID0022301 TK.Half.Life NA 18.15 hours 1compartment NA NA Rat Human +DTXSID0022301 Css NA 0.4175 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022301 Css NA 2.075 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022301 Css NA 0.316 mg/L PBTK NA 50% Rat Human +DTXSID0022301 Css NA 1.617 mg/L PBTK NA 95% Rat Human +DTXSID00223070 Clint 64 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00223070 Fup 0.0471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00223070 Vd NA 2.626 L/kg 1compartment NA NA Human Human +DTXSID00223070 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00223070 TK.Half.Life NA 8.772 hours 1compartment NA NA Human Human +DTXSID00223070 Css NA 0.3496 mg/L 3compartmentss NA 50% Human Human +DTXSID00223070 Css NA 2.416 mg/L 3compartmentss NA 95% Human Human +DTXSID00223070 Css NA 0.2364 mg/L PBTK NA 50% Human Human +DTXSID00223070 Css NA 1.561 mg/L PBTK NA 95% Human Human +DTXSID00223070 Clint 64 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00223070 Fup 0.0471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00223070 Vd NA 1.969 L/kg 1compartment NA NA Rat Human +DTXSID00223070 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00223070 TK.Half.Life NA 2.196 hours 1compartment NA NA Rat Human +DTXSID00223070 Css NA 0.04527 mg/L 3compartmentss NA 50% Rat Human +DTXSID00223070 Css NA 0.2628 mg/L 3compartmentss NA 95% Rat Human +DTXSID00223070 Css NA 0.03042 mg/L PBTK NA 50% Rat Human +DTXSID00223070 Css NA 0.1718 mg/L PBTK NA 95% Rat Human DTXSID0022353 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0022353 Fup 1.17e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0022353 Vd NA 0.1984 L/kg 1compartment NA NA Human Human +DTXSID0022353 Vd NA 0.1931 L/kg 1compartment NA NA Human Human DTXSID0022353 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID0022353 TK.Half.Life NA 12840 hours 1compartment NA NA Human Human -DTXSID0022353 Css NA 9.55 mg/L 3compartmentss NA 50% Human Human -DTXSID0022353 Css NA 105.1 mg/L 3compartmentss NA 95% Human Human -DTXSID0022353 Css NA 5.588 mg/L PBTK NA 50% Human Human -DTXSID0022353 Css NA 59.43 mg/L PBTK NA 95% Human Human +DTXSID0022353 TK.Half.Life NA 12500 hours 1compartment NA NA Human Human +DTXSID0022353 Css NA 9.526 mg/L 3compartmentss NA 50% Human Human +DTXSID0022353 Css NA 102.7 mg/L 3compartmentss NA 95% Human Human +DTXSID0022353 Css NA 5.624 mg/L PBTK NA 50% Human Human +DTXSID0022353 Css NA 59.7 mg/L PBTK NA 95% Human Human DTXSID0022353 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0022353 Fup 1.17e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0022353 Vd NA 0.1778 L/kg 1compartment NA NA Rat Human -DTXSID0022353 Days.Css NA 1081 Days PBTK NA NA Rat Human -DTXSID0022353 TK.Half.Life NA 3921 hours 1compartment NA NA Rat Human -DTXSID0022353 Css NA 5.728 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022353 Css NA 44.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022353 Css NA 3.099 mg/L PBTK NA 50% Rat Human -DTXSID0022353 Css NA 24.11 mg/L PBTK NA 95% Rat Human -DTXSID0022432 Clint NA 89.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022432 Fup NA 0.0252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022432 Vd NA 3.121 L/kg 1compartment NA NA Human Human -DTXSID0022432 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0022432 TK.Half.Life NA 23.74 hours 1compartment NA NA Human Human -DTXSID0022432 Css NA 0.8474 mg/L 3compartmentss NA 50% Human Human -DTXSID0022432 Css NA 4.937 mg/L 3compartmentss NA 95% Human Human -DTXSID0022432 Css NA 0.5881 mg/L PBTK NA 50% Human Human -DTXSID0022432 Css NA 3.324 mg/L PBTK NA 95% Human Human -DTXSID0022432 Clint NA 89.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022432 Fup NA 0.0252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022432 Vd NA 2.339 L/kg 1compartment NA NA Rat Human -DTXSID0022432 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0022432 TK.Half.Life NA 3.567 hours 1compartment NA NA Rat Human -DTXSID0022432 Css NA 0.4762 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022432 Css NA 2.192 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022432 Css NA 0.3153 mg/L PBTK NA 50% Rat Human -DTXSID0022432 Css NA 1.46 mg/L PBTK NA 95% Rat Human +DTXSID0022353 Vd NA 0.1749 L/kg 1compartment NA NA Rat Human +DTXSID0022353 Days.Css NA 651 Days PBTK NA NA Rat Human +DTXSID0022353 TK.Half.Life NA 3855 hours 1compartment NA NA Rat Human +DTXSID0022353 Css NA 1.305 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022353 Css NA 10.66 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022353 Css NA 0.7304 mg/L PBTK NA 50% Rat Human +DTXSID0022353 Css NA 5.965 mg/L PBTK NA 95% Rat Human +DTXSID0022432 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022432 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022432 Vd NA 3.099 L/kg 1compartment NA NA Human Human +DTXSID0022432 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID0022432 TK.Half.Life NA 90.44 hours 1compartment NA NA Human Human +DTXSID0022432 Css NA 3.454 mg/L 3compartmentss NA 50% Human Human +DTXSID0022432 Css NA 22.14 mg/L 3compartmentss NA 95% Human Human +DTXSID0022432 Css NA 2.382 mg/L PBTK NA 50% Human Human +DTXSID0022432 Css NA 14.97 mg/L PBTK NA 95% Human Human +DTXSID0022432 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022432 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022432 Vd NA 2.32 L/kg 1compartment NA NA Rat Human +DTXSID0022432 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID0022432 TK.Half.Life NA 12.5 hours 1compartment NA NA Rat Human +DTXSID0022432 Css NA 0.4526 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022432 Css NA 2.386 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022432 Css NA 0.309 mg/L PBTK NA 50% Rat Human +DTXSID0022432 Css NA 1.626 mg/L PBTK NA 95% Rat Human DTXSID0022436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0022436 Fup 0.163 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0022436 Vd NA 0.6076 L/kg 1compartment NA NA Human Human +DTXSID0022436 Vd NA 0.6232 L/kg 1compartment NA NA Human Human DTXSID0022436 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0022436 TK.Half.Life NA 24.63 hours 1compartment NA NA Human Human -DTXSID0022436 Css NA 4.347 mg/L 3compartmentss NA 50% Human Human -DTXSID0022436 Css NA 14.13 mg/L 3compartmentss NA 95% Human Human -DTXSID0022436 Css NA 3.112 mg/L PBTK NA 50% Human Human -DTXSID0022436 Css NA 9.171 mg/L PBTK NA 95% Human Human +DTXSID0022436 TK.Half.Life NA 25.33 hours 1compartment NA NA Human Human +DTXSID0022436 Css NA 3.522 mg/L 3compartmentss NA 50% Human Human +DTXSID0022436 Css NA 11.75 mg/L 3compartmentss NA 95% Human Human +DTXSID0022436 Css NA 2.553 mg/L PBTK NA 50% Human Human +DTXSID0022436 Css NA 7.618 mg/L PBTK NA 95% Human Human DTXSID0022436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0022436 Fup 0.163 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0022436 Vd NA 0.5551 L/kg 1compartment NA NA Rat Human +DTXSID0022436 Vd NA 0.567 L/kg 1compartment NA NA Rat Human DTXSID0022436 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022436 TK.Half.Life NA 7.546 hours 1compartment NA NA Rat Human -DTXSID0022436 Css NA 1.198 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022436 Css NA 3.153 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022436 Css NA 0.8222 mg/L PBTK NA 50% Rat Human -DTXSID0022436 Css NA 1.903 mg/L PBTK NA 95% Rat Human -DTXSID0022480 Clint NA 7.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0022436 TK.Half.Life NA 7.712 hours 1compartment NA NA Rat Human +DTXSID0022436 Css NA 0.05058 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022436 Css NA 0.2938 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022436 Css NA 0.03481 mg/L PBTK NA 50% Rat Human +DTXSID0022436 Css NA 0.1941 mg/L PBTK NA 95% Rat Human +DTXSID0022480 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0022480 Fup 0.255 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0022480 Vd NA 1.739 L/kg 1compartment NA NA Human Human DTXSID0022480 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022480 TK.Half.Life NA 5.271 hours 1compartment NA NA Human Human -DTXSID0022480 Css NA 0.2593 mg/L 3compartmentss NA 50% Human Human -DTXSID0022480 Css NA 1.418 mg/L 3compartmentss NA 95% Human Human -DTXSID0022480 Css NA 0.1955 mg/L PBTK NA 50% Human Human -DTXSID0022480 Css NA 1.013 mg/L PBTK NA 95% Human Human -DTXSID0022480 Clint NA 7.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0022480 TK.Half.Life NA 2.793 hours 1compartment NA NA Human Human +DTXSID0022480 Css NA 0.09576 mg/L 3compartmentss NA 50% Human Human +DTXSID0022480 Css NA 0.5904 mg/L 3compartmentss NA 95% Human Human +DTXSID0022480 Css NA 0.07136 mg/L PBTK NA 50% Human Human +DTXSID0022480 Css NA 0.4229 mg/L PBTK NA 95% Human Human +DTXSID0022480 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0022480 Fup 0.255 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0022480 Vd NA 1.371 L/kg 1compartment NA NA Rat Human DTXSID0022480 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022480 TK.Half.Life NA 1.966 hours 1compartment NA NA Rat Human -DTXSID0022480 Css NA 0.136 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022480 Css NA 0.533 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022480 Css NA 0.09874 mg/L PBTK NA 50% Rat Human -DTXSID0022480 Css NA 0.3616 mg/L PBTK NA 95% Rat Human +DTXSID0022480 TK.Half.Life NA 1.038 hours 1compartment NA NA Rat Human +DTXSID0022480 Css NA 0.01196 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022480 Css NA 0.05771 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022480 Css NA 0.009012 mg/L PBTK NA 50% Rat Human +DTXSID0022480 Css NA 0.04169 mg/L PBTK NA 95% Rat Human DTXSID0022563 Clint 12.59 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID0022563 Fup NA 0.0684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022563 Vd NA 1.734 L/kg 1compartment NA NA Human Human +DTXSID0022563 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022563 Vd NA 2.093 L/kg 1compartment NA NA Human Human DTXSID0022563 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022563 TK.Half.Life NA 10.65 hours 1compartment NA NA Human Human -DTXSID0022563 Css NA 0.8638 mg/L 3compartmentss NA 50% Human Human -DTXSID0022563 Css NA 5.729 mg/L 3compartmentss NA 95% Human Human -DTXSID0022563 Css NA 0.5639 mg/L PBTK NA 50% Human Human -DTXSID0022563 Css NA 3.605 mg/L PBTK NA 95% Human Human +DTXSID0022563 TK.Half.Life NA 9.909 hours 1compartment NA NA Human Human +DTXSID0022563 Css NA 0.5556 mg/L 3compartmentss NA 50% Human Human +DTXSID0022563 Css NA 3.77 mg/L 3compartmentss NA 95% Human Human +DTXSID0022563 Css NA 0.3796 mg/L PBTK NA 50% Human Human +DTXSID0022563 Css NA 2.433 mg/L PBTK NA 95% Human Human DTXSID0022563 Clint 12.59 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID0022563 Fup NA 0.0684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022563 Vd NA 1.308 L/kg 1compartment NA NA Rat Human +DTXSID0022563 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022563 Vd NA 1.588 L/kg 1compartment NA NA Rat Human DTXSID0022563 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022563 TK.Half.Life NA 3.819 hours 1compartment NA NA Rat Human -DTXSID0022563 Css NA 0.4717 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022563 Css NA 2.328 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022563 Css NA 0.2904 mg/L PBTK NA 50% Rat Human -DTXSID0022563 Css NA 1.384 mg/L PBTK NA 95% Rat Human -DTXSID0022565 Clint NA 7.449 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022565 Fup NA 0.4977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022565 Vd NA 0.6035 L/kg 1compartment NA NA Human Human +DTXSID0022563 TK.Half.Life NA 3.144 hours 1compartment NA NA Rat Human +DTXSID0022563 Css NA 0.07082 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022563 Css NA 0.3666 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022563 Css NA 0.04762 mg/L PBTK NA 50% Rat Human +DTXSID0022563 Css NA 0.23 mg/L PBTK NA 95% Rat Human +DTXSID0022565 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022565 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022565 Vd NA 0.5684 L/kg 1compartment NA NA Human Human DTXSID0022565 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022565 TK.Half.Life NA 0.9592 hours 1compartment NA NA Human Human -DTXSID0022565 Css NA 0.1191 mg/L 3compartmentss NA 50% Human Human -DTXSID0022565 Css NA 0.9485 mg/L 3compartmentss NA 95% Human Human -DTXSID0022565 Css NA 0.08898 mg/L PBTK NA 50% Human Human -DTXSID0022565 Css NA 0.614 mg/L PBTK NA 95% Human Human -DTXSID0022565 Clint NA 7.449 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022565 Fup NA 0.4977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022565 Vd NA 0.5905 L/kg 1compartment NA NA Rat Human +DTXSID0022565 TK.Half.Life NA 7.925 hours 1compartment NA NA Human Human +DTXSID0022565 Css NA 1.543 mg/L 3compartmentss NA 50% Human Human +DTXSID0022565 Css NA 7.368 mg/L 3compartmentss NA 95% Human Human +DTXSID0022565 Css NA 1.141 mg/L PBTK NA 50% Human Human +DTXSID0022565 Css NA 4.611 mg/L PBTK NA 95% Human Human +DTXSID0022565 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022565 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022565 Vd NA 0.5589 L/kg 1compartment NA NA Rat Human DTXSID0022565 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022565 TK.Half.Life NA 0.5082 hours 1compartment NA NA Rat Human -DTXSID0022565 Css NA 0.05948 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022565 Css NA 0.3565 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022565 Css NA 0.04285 mg/L PBTK NA 50% Rat Human -DTXSID0022565 Css NA 0.214 mg/L PBTK NA 95% Rat Human -DTXSID0022569 Clint NA 182.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022569 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022569 Vd NA 129.9 L/kg 1compartment NA NA Human Human -DTXSID0022569 Days.Css NA 99 Days PBTK NA NA Human Human -DTXSID0022569 TK.Half.Life NA 460 hours 1compartment NA NA Human Human -DTXSID0022569 Css NA 0.01774 mg/L 3compartmentss NA 50% Human Human -DTXSID0022569 Css NA 0.1128 mg/L 3compartmentss NA 95% Human Human -DTXSID0022569 Css NA 0.2876 mg/L PBTK NA 50% Human Human -DTXSID0022569 Css NA 1.658 mg/L PBTK NA 95% Human Human -DTXSID0022569 Clint NA 182.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022569 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022569 Vd NA 113.2 L/kg 1compartment NA NA Rat Human -DTXSID0022569 Days.Css NA 68 Days PBTK NA NA Rat Human -DTXSID0022569 TK.Half.Life NA 71.01 hours 1compartment NA NA Rat Human -DTXSID0022569 Css NA 0.009138 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022569 Css NA 0.03979 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022569 Css NA 0.1584 mg/L PBTK NA 50% Rat Human -DTXSID0022569 Css NA 0.6712 mg/L PBTK NA 95% Rat Human -DTXSID0022640 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0022565 TK.Half.Life NA 2.643 hours 1compartment NA NA Rat Human +DTXSID0022565 Css NA 0.09709 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022565 Css NA 0.4101 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022565 Css NA 0.07094 mg/L PBTK NA 50% Rat Human +DTXSID0022565 Css NA 0.249 mg/L PBTK NA 95% Rat Human +DTXSID0022569 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022569 Fup 0.0418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022569 Vd NA 4.406 L/kg 1compartment NA NA Human Human +DTXSID0022569 Days.Css NA 23 Days PBTK NA NA Human Human +DTXSID0022569 TK.Half.Life NA 132.2 hours 1compartment NA NA Human Human +DTXSID0022569 Css NA 3.02 mg/L 3compartmentss NA 50% Human Human +DTXSID0022569 Css NA 17.83 mg/L 3compartmentss NA 95% Human Human +DTXSID0022569 Css NA 2.323 mg/L PBTK NA 50% Human Human +DTXSID0022569 Css NA 13.69 mg/L PBTK NA 95% Human Human +DTXSID0022569 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022569 Fup 0.0418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022569 Vd NA 3.346 L/kg 1compartment NA NA Rat Human +DTXSID0022569 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID0022569 TK.Half.Life NA 17.61 hours 1compartment NA NA Rat Human +DTXSID0022569 Css NA 0.3968 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022569 Css NA 1.93 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022569 Css NA 0.3066 mg/L PBTK NA 50% Rat Human +DTXSID0022569 Css NA 1.544 mg/L PBTK NA 95% Rat Human +DTXSID0022640 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0022640 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0022640 Vd NA 0.454 L/kg 1compartment NA NA Human Human +DTXSID0022640 Vd NA 0.3569 L/kg 1compartment NA NA Human Human DTXSID0022640 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022640 TK.Half.Life NA 7.342 hours 1compartment NA NA Human Human -DTXSID0022640 Css NA 1.871 mg/L 3compartmentss NA 50% Human Human -DTXSID0022640 Css NA 7.99 mg/L 3compartmentss NA 95% Human Human -DTXSID0022640 Css NA 1.341 mg/L PBTK NA 50% Human Human -DTXSID0022640 Css NA 5.044 mg/L PBTK NA 95% Human Human -DTXSID0022640 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0022640 TK.Half.Life NA 5.776 hours 1compartment NA NA Human Human +DTXSID0022640 Css NA 1.045 mg/L 3compartmentss NA 50% Human Human +DTXSID0022640 Css NA 4.752 mg/L 3compartmentss NA 95% Human Human +DTXSID0022640 Css NA 0.7152 mg/L PBTK NA 50% Human Human +DTXSID0022640 Css NA 2.949 mg/L PBTK NA 95% Human Human +DTXSID0022640 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0022640 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0022640 Vd NA 0.4755 L/kg 1compartment NA NA Rat Human +DTXSID0022640 Vd NA 0.365 L/kg 1compartment NA NA Rat Human DTXSID0022640 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022640 TK.Half.Life NA 2.62 hours 1compartment NA NA Rat Human -DTXSID0022640 Css NA 0.509 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022640 Css NA 1.878 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022640 Css NA 0.3475 mg/L PBTK NA 50% Rat Human -DTXSID0022640 Css NA 1.099 mg/L PBTK NA 95% Rat Human -DTXSID0022644 Clint NA 12.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022644 Fup NA 0.1278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022644 Vd NA 1.916 L/kg 1compartment NA NA Human Human +DTXSID0022640 TK.Half.Life NA 2.011 hours 1compartment NA NA Rat Human +DTXSID0022640 Css NA 0.005714 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022640 Css NA 0.02543 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022640 Css NA 0.00373 mg/L PBTK NA 50% Rat Human +DTXSID0022640 Css NA 0.01497 mg/L PBTK NA 95% Rat Human +DTXSID0022644 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022644 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022644 Vd NA 2.137 L/kg 1compartment NA NA Human Human DTXSID0022644 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022644 TK.Half.Life NA 5.093 hours 1compartment NA NA Human Human -DTXSID0022644 Css NA 0.265 mg/L 3compartmentss NA 50% Human Human -DTXSID0022644 Css NA 2.182 mg/L 3compartmentss NA 95% Human Human -DTXSID0022644 Css NA 0.2134 mg/L PBTK NA 50% Human Human -DTXSID0022644 Css NA 1.543 mg/L PBTK NA 95% Human Human -DTXSID0022644 Clint NA 12.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022644 Fup NA 0.1278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022644 Vd NA 1.914 L/kg 1compartment NA NA Rat Human +DTXSID0022644 TK.Half.Life NA 3.426 hours 1compartment NA NA Human Human +DTXSID0022644 Css NA 0.1131 mg/L 3compartmentss NA 50% Human Human +DTXSID0022644 Css NA 1.01 mg/L 3compartmentss NA 95% Human Human +DTXSID0022644 Css NA 0.09629 mg/L PBTK NA 50% Human Human +DTXSID0022644 Css NA 0.7378 mg/L PBTK NA 95% Human Human +DTXSID0022644 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022644 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022644 Vd NA 2.141 L/kg 1compartment NA NA Rat Human DTXSID0022644 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022644 TK.Half.Life NA 3.088 hours 1compartment NA NA Rat Human -DTXSID0022644 Css NA 0.1409 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022644 Css NA 0.9387 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022644 Css NA 0.1094 mg/L PBTK NA 50% Rat Human -DTXSID0022644 Css NA 0.6085 mg/L PBTK NA 95% Rat Human -DTXSID0022646 Clint NA 30.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022646 Fup NA 0.0888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022646 Vd NA 3.686 L/kg 1compartment NA NA Human Human +DTXSID0022644 TK.Half.Life NA 1.997 hours 1compartment NA NA Rat Human +DTXSID0022644 Css NA 0.01421 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022644 Css NA 0.1055 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022644 Css NA 0.01216 mg/L PBTK NA 50% Rat Human +DTXSID0022644 Css NA 0.07529 mg/L PBTK NA 95% Rat Human +DTXSID0022646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022646 Fup 0.0829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022646 Vd NA 3.637 L/kg 1compartment NA NA Human Human DTXSID0022646 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022646 TK.Half.Life NA 4.99 hours 1compartment NA NA Human Human -DTXSID0022646 Css NA 0.0802 mg/L 3compartmentss NA 50% Human Human -DTXSID0022646 Css NA 0.5756 mg/L 3compartmentss NA 95% Human Human -DTXSID0022646 Css NA 0.06805 mg/L PBTK NA 50% Human Human -DTXSID0022646 Css NA 0.4444 mg/L PBTK NA 95% Human Human -DTXSID0022646 Clint NA 30.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022646 Fup NA 0.0888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022646 Vd NA 3.136 L/kg 1compartment NA NA Rat Human +DTXSID0022646 TK.Half.Life NA 5.914 hours 1compartment NA NA Human Human +DTXSID0022646 Css NA 0.1089 mg/L 3compartmentss NA 50% Human Human +DTXSID0022646 Css NA 0.833 mg/L 3compartmentss NA 95% Human Human +DTXSID0022646 Css NA 0.09331 mg/L PBTK NA 50% Human Human +DTXSID0022646 Css NA 0.6512 mg/L PBTK NA 95% Human Human +DTXSID0022646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022646 Fup 0.0829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022646 Vd NA 3.138 L/kg 1compartment NA NA Rat Human DTXSID0022646 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022646 TK.Half.Life NA 1.549 hours 1compartment NA NA Rat Human -DTXSID0022646 Css NA 0.0443 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022646 Css NA 0.2699 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022646 Css NA 0.03668 mg/L PBTK NA 50% Rat Human -DTXSID0022646 Css NA 0.2074 mg/L PBTK NA 95% Rat Human -DTXSID0022690 Clint NA 16.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022690 Fup NA 0.0642 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022690 Vd NA 2.55 L/kg 1compartment NA NA Human Human -DTXSID0022690 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022690 TK.Half.Life NA 9.377 hours 1compartment NA NA Human Human -DTXSID0022690 Css NA 0.4078 mg/L 3compartmentss NA 50% Human Human -DTXSID0022690 Css NA 3.125 mg/L 3compartmentss NA 95% Human Human -DTXSID0022690 Css NA 0.3068 mg/L PBTK NA 50% Human Human -DTXSID0022690 Css NA 2.144 mg/L PBTK NA 95% Human Human -DTXSID0022690 Clint NA 16.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022690 Fup NA 0.0642 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022690 Vd NA 2.189 L/kg 1compartment NA NA Rat Human -DTXSID0022690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022690 TK.Half.Life NA 3.834 hours 1compartment NA NA Rat Human -DTXSID0022690 Css NA 0.2266 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022690 Css NA 1.415 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022690 Css NA 0.164 mg/L PBTK NA 50% Rat Human -DTXSID0022690 Css NA 0.9163 mg/L PBTK NA 95% Rat Human -DTXSID0022692 Clint NA 2.641 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0022646 TK.Half.Life NA 1.925 hours 1compartment NA NA Rat Human +DTXSID0022646 Css NA 0.01394 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022646 Css NA 0.08562 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022646 Css NA 0.01212 mg/L PBTK NA 50% Rat Human +DTXSID0022646 Css NA 0.06778 mg/L PBTK NA 95% Rat Human +DTXSID0022690 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022690 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022690 Vd NA 3.508 L/kg 1compartment NA NA Human Human +DTXSID0022690 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0022690 TK.Half.Life NA 22.64 hours 1compartment NA NA Human Human +DTXSID0022690 Css NA 0.6282 mg/L 3compartmentss NA 50% Human Human +DTXSID0022690 Css NA 3.937 mg/L 3compartmentss NA 95% Human Human +DTXSID0022690 Css NA 0.527 mg/L PBTK NA 50% Human Human +DTXSID0022690 Css NA 3.021 mg/L PBTK NA 95% Human Human +DTXSID0022690 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022690 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022690 Vd NA 2.97 L/kg 1compartment NA NA Rat Human +DTXSID0022690 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0022690 TK.Half.Life NA 6.118 hours 1compartment NA NA Rat Human +DTXSID0022690 Css NA 0.0764 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022690 Css NA 0.3491 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022690 Css NA 0.06492 mg/L PBTK NA 50% Rat Human +DTXSID0022690 Css NA 0.273 mg/L PBTK NA 95% Rat Human +DTXSID0022692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0022692 Fup 0.092 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0022692 Vd NA 1.551 L/kg 1compartment NA NA Human Human -DTXSID0022692 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0022692 TK.Half.Life NA 25.34 hours 1compartment NA NA Human Human -DTXSID0022692 Css NA 2.38 mg/L 3compartmentss NA 50% Human Human -DTXSID0022692 Css NA 12.98 mg/L 3compartmentss NA 95% Human Human -DTXSID0022692 Css NA 1.582 mg/L PBTK NA 50% Human Human -DTXSID0022692 Css NA 8.079 mg/L PBTK NA 95% Human Human -DTXSID0022692 Clint NA 2.641 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0022692 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0022692 TK.Half.Life NA 4.699 hours 1compartment NA NA Human Human +DTXSID0022692 Css NA 0.3402 mg/L 3compartmentss NA 50% Human Human +DTXSID0022692 Css NA 2.49 mg/L 3compartmentss NA 95% Human Human +DTXSID0022692 Css NA 0.2248 mg/L PBTK NA 50% Human Human +DTXSID0022692 Css NA 1.556 mg/L PBTK NA 95% Human Human +DTXSID0022692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0022692 Fup 0.092 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0022692 Vd NA 1.192 L/kg 1compartment NA NA Rat Human -DTXSID0022692 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0022692 TK.Half.Life NA 9.037 hours 1compartment NA NA Rat Human -DTXSID0022692 Css NA 1.16 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022692 Css NA 4.906 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022692 Css NA 0.7258 mg/L PBTK NA 50% Rat Human -DTXSID0022692 Css NA 2.818 mg/L PBTK NA 95% Rat Human -DTXSID0022721 Clint NA 172.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022721 Fup NA 0.0105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022721 Vd NA 124.9 L/kg 1compartment NA NA Human Human -DTXSID0022721 Days.Css NA 101 Days PBTK NA NA Human Human -DTXSID0022721 TK.Half.Life NA 469.3 hours 1compartment NA NA Human Human -DTXSID0022721 Css NA 0.01987 mg/L 3compartmentss NA 50% Human Human -DTXSID0022721 Css NA 0.1195 mg/L 3compartmentss NA 95% Human Human -DTXSID0022721 Css NA 0.31 mg/L PBTK NA 50% Human Human -DTXSID0022721 Css NA 1.693 mg/L PBTK NA 95% Human Human -DTXSID0022721 Clint NA 172.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022721 Fup NA 0.0105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022721 Vd NA 108.8 L/kg 1compartment NA NA Rat Human -DTXSID0022721 Days.Css NA 69 Days PBTK NA NA Rat Human -DTXSID0022721 TK.Half.Life NA 72.17 hours 1compartment NA NA Rat Human -DTXSID0022721 Css NA 0.0101 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022721 Css NA 0.04448 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022721 Css NA 0.1664 mg/L PBTK NA 50% Rat Human -DTXSID0022721 Css NA 0.7107 mg/L PBTK NA 95% Rat Human -DTXSID0022725 Clint NA 3.516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0022692 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0022692 TK.Half.Life NA 1.822 hours 1compartment NA NA Rat Human +DTXSID0022692 Css NA 0.04351 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022692 Css NA 0.2713 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022692 Css NA 0.02822 mg/L PBTK NA 50% Rat Human +DTXSID0022692 Css NA 0.1661 mg/L PBTK NA 95% Rat Human +DTXSID0022721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022721 Fup 0.0612 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022721 Vd NA 7.862 L/kg 1compartment NA NA Human Human +DTXSID0022721 Days.Css NA 46 Days PBTK NA NA Human Human +DTXSID0022721 TK.Half.Life NA 234.1 hours 1compartment NA NA Human Human +DTXSID0022721 Css NA 2.3 mg/L 3compartmentss NA 50% Human Human +DTXSID0022721 Css NA 13.52 mg/L 3compartmentss NA 95% Human Human +DTXSID0022721 Css NA 2.344 mg/L PBTK NA 50% Human Human +DTXSID0022721 Css NA 13.62 mg/L PBTK NA 95% Human Human +DTXSID0022721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022721 Fup 0.0612 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022721 Vd NA 6.124 L/kg 1compartment NA NA Rat Human +DTXSID0022721 Days.Css NA 27 Days PBTK NA NA Rat Human +DTXSID0022721 TK.Half.Life NA 31.61 hours 1compartment NA NA Rat Human +DTXSID0022721 Css NA 0.2932 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022721 Css NA 1.45 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022721 Css NA 0.3059 mg/L PBTK NA 50% Rat Human +DTXSID0022721 Css NA 1.563 mg/L PBTK NA 95% Rat Human +DTXSID0022725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0022725 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0022725 Vd NA 0.183 L/kg 1compartment NA NA Human Human -DTXSID0022725 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID0022725 TK.Half.Life NA 85.3 hours 1compartment NA NA Human Human -DTXSID0022725 Css NA 37.72 mg/L 3compartmentss NA 50% Human Human -DTXSID0022725 Css NA 285.3 mg/L 3compartmentss NA 95% Human Human -DTXSID0022725 Css NA 21.64 mg/L PBTK NA 50% Human Human -DTXSID0022725 Css NA 165.6 mg/L PBTK NA 95% Human Human -DTXSID0022725 Clint NA 3.516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0022725 Vd NA 0.1656 L/kg 1compartment NA NA Human Human +DTXSID0022725 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0022725 TK.Half.Life NA 14.65 hours 1compartment NA NA Human Human +DTXSID0022725 Css NA 15.44 mg/L 3compartmentss NA 50% Human Human +DTXSID0022725 Css NA 145.9 mg/L 3compartmentss NA 95% Human Human +DTXSID0022725 Css NA 8.492 mg/L PBTK NA 50% Human Human +DTXSID0022725 Css NA 80.27 mg/L PBTK NA 95% Human Human +DTXSID0022725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0022725 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0022725 Vd NA 0.1775 L/kg 1compartment NA NA Rat Human -DTXSID0022725 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID0022725 TK.Half.Life NA 50.37 hours 1compartment NA NA Rat Human -DTXSID0022725 Css NA 45.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022725 Css NA 251.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022725 Css NA 23.96 mg/L PBTK NA 50% Rat Human -DTXSID0022725 Css NA 135.3 mg/L PBTK NA 95% Rat Human -DTXSID0022727 Clint NA 72.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022727 Fup NA 0.0075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022727 Vd NA 3390 L/kg 1compartment NA NA Human Human -DTXSID0022727 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID0022727 TK.Half.Life NA 30180 hours 1compartment NA NA Human Human -DTXSID0022727 Css NA 0.001244 mg/L 3compartmentss NA 50% Human Human -DTXSID0022727 Css NA 0.007759 mg/L 3compartmentss NA 95% Human Human -DTXSID0022727 Css NA 0.7415 mg/L PBTK NA 50% Human Human -DTXSID0022727 Css NA 4.22 mg/L PBTK NA 95% Human Human -DTXSID0022727 Clint NA 72.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022727 Fup NA 0.0075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022727 Vd NA 3159 L/kg 1compartment NA NA Rat Human +DTXSID0022725 Vd NA 0.1635 L/kg 1compartment NA NA Rat Human +DTXSID0022725 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0022725 TK.Half.Life NA 9.829 hours 1compartment NA NA Rat Human +DTXSID0022725 Css NA 0.7108 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022725 Css NA 7.414 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022725 Css NA 0.3982 mg/L PBTK NA 50% Rat Human +DTXSID0022725 Css NA 4.174 mg/L PBTK NA 95% Rat Human +DTXSID0022727 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022727 Fup 0.00976 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022727 Vd NA 466.7 L/kg 1compartment NA NA Human Human +DTXSID0022727 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID0022727 TK.Half.Life NA 22360000 hours 1compartment NA NA Human Human +DTXSID0022727 Css NA 51.95 mg/L 3compartmentss NA 50% Human Human +DTXSID0022727 Css NA 137.9 mg/L 3compartmentss NA 95% Human Human +DTXSID0022727 Css NA 3595 mg/L PBTK NA 50% Human Human +DTXSID0022727 Css NA 7738 mg/L PBTK NA 95% Human Human +DTXSID0022727 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022727 Fup 0.00976 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022727 Vd NA 421 L/kg 1compartment NA NA Rat Human DTXSID0022727 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID0022727 TK.Half.Life NA 4980 hours 1compartment NA NA Rat Human -DTXSID0022727 Css NA 0.0006347 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022727 Css NA 0.002619 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022727 Css NA 0.4026 mg/L PBTK NA 50% Rat Human -DTXSID0022727 Css NA 1.678 mg/L PBTK NA 95% Rat Human +DTXSID0022727 TK.Half.Life NA 1711000 hours 1compartment NA NA Rat Human +DTXSID0022727 Css NA 2.918 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022727 Css NA 5.232 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022727 Css NA 231.2 mg/L PBTK NA 50% Rat Human +DTXSID0022727 Css NA 311.1 mg/L PBTK NA 95% Rat Human +DTXSID0022773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022773 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0022773 Vd NA 0.239 L/kg 1compartment NA NA Human Human +DTXSID0022773 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0022773 TK.Half.Life NA 0.6273 hours 1compartment NA NA Human Human +DTXSID0022773 Css NA 0.1286 mg/L 3compartmentss NA 50% Human Human +DTXSID0022773 Css NA 1.188 mg/L 3compartmentss NA 95% Human Human +DTXSID0022773 Css NA 0.07786 mg/L PBTK NA 50% Human Human +DTXSID0022773 Css NA 0.6991 mg/L PBTK NA 95% Human Human +DTXSID0022773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022773 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0022773 Vd NA 0.2384 L/kg 1compartment NA NA Rat Human +DTXSID0022773 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0022773 TK.Half.Life NA 0.3711 hours 1compartment NA NA Rat Human +DTXSID0022773 Css NA 0.001208 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022773 Css NA 0.008845 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022773 Css NA 0.0006905 mg/L PBTK NA 50% Rat Human +DTXSID0022773 Css NA 0.0049 mg/L PBTK NA 95% Rat Human DTXSID0022777 Clint 25.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID0022777 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022777 Vd NA 1.202 L/kg 1compartment NA NA Human Human +DTXSID0022777 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022777 Vd NA 2.116 L/kg 1compartment NA NA Human Human DTXSID0022777 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0022777 TK.Half.Life NA 15.42 hours 1compartment NA NA Human Human -DTXSID0022777 Css NA 2.181 mg/L 3compartmentss NA 50% Human Human -DTXSID0022777 Css NA 20.44 mg/L 3compartmentss NA 95% Human Human -DTXSID0022777 Css NA 1.326 mg/L PBTK NA 50% Human Human -DTXSID0022777 Css NA 12.11 mg/L PBTK NA 95% Human Human +DTXSID0022777 TK.Half.Life NA 16.45 hours 1compartment NA NA Human Human +DTXSID0022777 Css NA 1.087 mg/L 3compartmentss NA 50% Human Human +DTXSID0022777 Css NA 9.144 mg/L 3compartmentss NA 95% Human Human +DTXSID0022777 Css NA 0.7081 mg/L PBTK NA 50% Human Human +DTXSID0022777 Css NA 5.61 mg/L PBTK NA 95% Human Human DTXSID0022777 Clint 25.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID0022777 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022777 Vd NA 0.8864 L/kg 1compartment NA NA Rat Human -DTXSID0022777 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022777 TK.Half.Life NA 6.46 hours 1compartment NA NA Rat Human -DTXSID0022777 Css NA 1.24 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022777 Css NA 9.303 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022777 Css NA 0.707 mg/L PBTK NA 50% Rat Human -DTXSID0022777 Css NA 5.149 mg/L PBTK NA 95% Rat Human -DTXSID0022800 Clint NA 1.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022800 Fup NA 0.1665 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022800 Vd NA 0.2619 L/kg 1compartment NA NA Human Human +DTXSID0022777 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022777 Vd NA 1.576 L/kg 1compartment NA NA Rat Human +DTXSID0022777 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID0022777 TK.Half.Life NA 33.16 hours 1compartment NA NA Rat Human +DTXSID0022777 Css NA 1.018 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022777 Css NA 4.822 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022777 Css NA 0.6487 mg/L PBTK NA 50% Rat Human +DTXSID0022777 Css NA 2.857 mg/L PBTK NA 95% Rat Human +DTXSID0022800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022800 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022800 Vd NA 0.2951 L/kg 1compartment NA NA Human Human DTXSID0022800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022800 TK.Half.Life NA 3.257 hours 1compartment NA NA Human Human -DTXSID0022800 Css NA 1.611 mg/L 3compartmentss NA 50% Human Human -DTXSID0022800 Css NA 6.983 mg/L 3compartmentss NA 95% Human Human -DTXSID0022800 Css NA 1 mg/L PBTK NA 50% Human Human -DTXSID0022800 Css NA 4.177 mg/L PBTK NA 95% Human Human -DTXSID0022800 Clint NA 1.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022800 Fup NA 0.1665 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022800 Vd NA 0.2658 L/kg 1compartment NA NA Rat Human +DTXSID0022800 TK.Half.Life NA 0.9413 hours 1compartment NA NA Human Human +DTXSID0022800 Css NA 0.1596 mg/L 3compartmentss NA 50% Human Human +DTXSID0022800 Css NA 1.032 mg/L 3compartmentss NA 95% Human Human +DTXSID0022800 Css NA 0.1018 mg/L PBTK NA 50% Human Human +DTXSID0022800 Css NA 0.6367 mg/L PBTK NA 95% Human Human +DTXSID0022800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022800 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022800 Vd NA 0.301 L/kg 1compartment NA NA Rat Human DTXSID0022800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022800 TK.Half.Life NA 1.715 hours 1compartment NA NA Rat Human -DTXSID0022800 Css NA 0.7022 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022800 Css NA 2.273 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022800 Css NA 0.4119 mg/L PBTK NA 50% Rat Human -DTXSID0022800 Css NA 1.27 mg/L PBTK NA 95% Rat Human +DTXSID0022800 TK.Half.Life NA 0.5563 hours 1compartment NA NA Rat Human +DTXSID0022800 Css NA 0.001435 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022800 Css NA 0.007748 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022800 Css NA 0.0008696 mg/L PBTK NA 50% Rat Human +DTXSID0022800 Css NA 0.004446 mg/L PBTK NA 95% Rat Human DTXSID0022804 Clint 2.882 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0022804 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0022804 Vd NA 8.094 L/kg 1compartment NA NA Human Human DTXSID0022804 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0022804 TK.Half.Life NA 14.48 hours 1compartment NA NA Human Human -DTXSID0022804 Css NA 0.08022 mg/L 3compartmentss NA 50% Human Human -DTXSID0022804 Css NA 0.7231 mg/L 3compartmentss NA 95% Human Human -DTXSID0022804 Css NA 0.08985 mg/L PBTK NA 50% Human Human -DTXSID0022804 Css NA 0.5689 mg/L PBTK NA 95% Human Human +DTXSID0022804 Css NA 0.1027 mg/L 3compartmentss NA 50% Human Human +DTXSID0022804 Css NA 0.6596 mg/L 3compartmentss NA 95% Human Human +DTXSID0022804 Css NA 0.137 mg/L PBTK NA 50% Human Human +DTXSID0022804 Css NA 0.8825 mg/L PBTK NA 95% Human Human DTXSID0022804 Clint 2.882 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID0022804 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0022804 Vd NA 8.274 L/kg 1compartment NA NA Rat Human DTXSID0022804 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0022804 TK.Half.Life NA 7.211 hours 1compartment NA NA Rat Human -DTXSID0022804 Css NA 0.05874 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022804 Css NA 0.4632 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022804 Css NA 0.06524 mg/L PBTK NA 50% Rat Human -DTXSID0022804 Css NA 0.3207 mg/L PBTK NA 95% Rat Human +DTXSID0022804 Css NA 0.01092 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022804 Css NA 0.05557 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022804 Css NA 0.01515 mg/L PBTK NA 50% Rat Human +DTXSID0022804 Css NA 0.07712 mg/L PBTK NA 95% Rat Human DTXSID0022808 Clint 195.1 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0022808 Fup 0.05 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID0022808 Vd NA 3.132 L/kg 1compartment NA NA Human Human +DTXSID0022808 Vd NA 3.339 L/kg 1compartment NA NA Human Human DTXSID0022808 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022808 TK.Half.Life NA 10.64 hours 1compartment NA NA Human Human -DTXSID0022808 Css NA 0.3538 mg/L 3compartmentss NA 50% Human Human -DTXSID0022808 Css NA 2.232 mg/L 3compartmentss NA 95% Human Human -DTXSID0022808 Css NA 0.2055 mg/L PBTK NA 50% Human Human -DTXSID0022808 Css NA 1.297 mg/L PBTK NA 95% Human Human +DTXSID0022808 TK.Half.Life NA 8.186 hours 1compartment NA NA Human Human +DTXSID0022808 Css NA 0.1889 mg/L 3compartmentss NA 50% Human Human +DTXSID0022808 Css NA 1.244 mg/L 3compartmentss NA 95% Human Human +DTXSID0022808 Css NA 0.1473 mg/L PBTK NA 50% Human Human +DTXSID0022808 Css NA 0.9704 mg/L PBTK NA 95% Human Human DTXSID0022808 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID0022808 Fup 0.1 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID0022808 Vd NA 2.361 L/kg 1compartment NA NA Rat Rat -DTXSID0022808 Days.Css NA 2757 Days PBTK NA NA Rat Rat -DTXSID0022808 TK.Half.Life NA 2377 hours 1compartment NA NA Rat Rat -DTXSID0022808 Css NA 462 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0022808 Css NA 924.8 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0022808 Css NA 250 mg/L PBTK NA 50% Rat Rat -DTXSID0022808 Css NA 499.9 mg/L PBTK NA 95% Rat Rat -DTXSID0022850 Clint NA 16.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022850 Fup NA 0.3755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022850 Vd NA 3.527 L/kg 1compartment NA NA Human Human +DTXSID0022808 Vd NA 2.656 L/kg 1compartment NA NA Rat Rat +DTXSID0022808 Days.Css NA 651 Days PBTK NA NA Rat Rat +DTXSID0022808 TK.Half.Life NA 605.4 hours 1compartment NA NA Rat Rat +DTXSID0022808 Css NA 14.55 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0022808 Css NA 29.16 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0022808 Css NA 11.74 mg/L PBTK NA 50% Rat Rat +DTXSID0022808 Css NA 23.56 mg/L PBTK NA 95% Rat Rat +DTXSID00228303 Clint 10.72 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00228303 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00228303 Vd NA 0.8717 L/kg 1compartment NA NA Human Human +DTXSID00228303 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00228303 TK.Half.Life NA 1.564 hours 1compartment NA NA Human Human +DTXSID00228303 Css NA 0.1281 mg/L 3compartmentss NA 50% Human Human +DTXSID00228303 Css NA 0.8973 mg/L 3compartmentss NA 95% Human Human +DTXSID00228303 Css NA 0.0941 mg/L PBTK NA 50% Human Human +DTXSID00228303 Css NA 0.5997 mg/L PBTK NA 95% Human Human +DTXSID00228303 Clint 10.72 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00228303 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00228303 Vd NA 0.7713 L/kg 1compartment NA NA Rat Human +DTXSID00228303 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00228303 TK.Half.Life NA 0.757 hours 1compartment NA NA Rat Human +DTXSID00228303 Css NA 0.01543 mg/L 3compartmentss NA 50% Rat Human +DTXSID00228303 Css NA 0.08508 mg/L 3compartmentss NA 95% Rat Human +DTXSID00228303 Css NA 0.01137 mg/L PBTK NA 50% Rat Human +DTXSID00228303 Css NA 0.05606 mg/L PBTK NA 95% Rat Human +DTXSID0022850 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022850 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022850 Vd NA 3.176 L/kg 1compartment NA NA Human Human DTXSID0022850 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022850 TK.Half.Life NA 3.415 hours 1compartment NA NA Human Human -DTXSID0022850 Css NA 0.04177 mg/L 3compartmentss NA 50% Human Human -DTXSID0022850 Css NA 0.3605 mg/L 3compartmentss NA 95% Human Human -DTXSID0022850 Css NA 0.04932 mg/L PBTK NA 50% Human Human -DTXSID0022850 Css NA 0.3189 mg/L PBTK NA 95% Human Human -DTXSID0022850 Clint NA 16.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022850 Fup NA 0.3755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022850 Vd NA 3.583 L/kg 1compartment NA NA Rat Human +DTXSID0022850 TK.Half.Life NA 3.001 hours 1compartment NA NA Human Human +DTXSID0022850 Css NA 0.03697 mg/L 3compartmentss NA 50% Human Human +DTXSID0022850 Css NA 0.3274 mg/L 3compartmentss NA 95% Human Human +DTXSID0022850 Css NA 0.04119 mg/L PBTK NA 50% Human Human +DTXSID0022850 Css NA 0.2892 mg/L PBTK NA 95% Human Human +DTXSID0022850 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022850 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022850 Vd NA 3.22 L/kg 1compartment NA NA Rat Human DTXSID0022850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022850 TK.Half.Life NA 1.933 hours 1compartment NA NA Rat Human -DTXSID0022850 Css NA 0.02128 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022850 Css NA 0.1505 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022850 Css NA 0.02548 mg/L PBTK NA 50% Rat Human -DTXSID0022850 Css NA 0.1328 mg/L PBTK NA 95% Rat Human -DTXSID0022854 Clint NA 26.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022854 Fup NA 0.0321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022854 Vd NA 1.316 L/kg 1compartment NA NA Human Human +DTXSID0022850 TK.Half.Life NA 1.673 hours 1compartment NA NA Rat Human +DTXSID0022850 Css NA 0.004458 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022850 Css NA 0.03159 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022850 Css NA 0.005164 mg/L PBTK NA 50% Rat Human +DTXSID0022850 Css NA 0.02825 mg/L PBTK NA 95% Rat Human +DTXSID0022854 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022854 Fup 0.0753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022854 Vd NA 2.403 L/kg 1compartment NA NA Human Human DTXSID0022854 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022854 TK.Half.Life NA 6.809 hours 1compartment NA NA Human Human -DTXSID0022854 Css NA 0.758 mg/L 3compartmentss NA 50% Human Human -DTXSID0022854 Css NA 7.15 mg/L 3compartmentss NA 95% Human Human -DTXSID0022854 Css NA 0.4871 mg/L PBTK NA 50% Human Human -DTXSID0022854 Css NA 4.276 mg/L PBTK NA 95% Human Human -DTXSID0022854 Clint NA 26.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022854 Fup NA 0.0321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022854 Vd NA 1.071 L/kg 1compartment NA NA Rat Human +DTXSID0022854 TK.Half.Life NA 9.821 hours 1compartment NA NA Human Human +DTXSID0022854 Css NA 0.4654 mg/L 3compartmentss NA 50% Human Human +DTXSID0022854 Css NA 3.275 mg/L 3compartmentss NA 95% Human Human +DTXSID0022854 Css NA 0.3306 mg/L PBTK NA 50% Human Human +DTXSID0022854 Css NA 2.156 mg/L PBTK NA 95% Human Human +DTXSID0022854 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022854 Fup 0.0753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022854 Vd NA 1.928 L/kg 1compartment NA NA Rat Human DTXSID0022854 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022854 TK.Half.Life NA 3.177 hours 1compartment NA NA Rat Human -DTXSID0022854 Css NA 0.4297 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022854 Css NA 3.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022854 Css NA 0.2589 mg/L PBTK NA 50% Rat Human -DTXSID0022854 Css NA 1.763 mg/L PBTK NA 95% Rat Human -DTXSID0022858 Clint NA 39.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022858 Fup NA 0.1901 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022858 Vd NA 1.792 L/kg 1compartment NA NA Human Human -DTXSID0022858 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022858 TK.Half.Life NA 1.962 hours 1compartment NA NA Human Human -DTXSID0022858 Css NA 0.0489 mg/L 3compartmentss NA 50% Human Human -DTXSID0022858 Css NA 0.3765 mg/L 3compartmentss NA 95% Human Human -DTXSID0022858 Css NA 0.04166 mg/L PBTK NA 50% Human Human -DTXSID0022858 Css NA 0.2829 mg/L PBTK NA 95% Human Human -DTXSID0022858 Clint NA 39.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022858 Fup NA 0.1901 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022858 Vd NA 1.785 L/kg 1compartment NA NA Rat Human -DTXSID0022858 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022858 TK.Half.Life NA 1.055 hours 1compartment NA NA Rat Human -DTXSID0022858 Css NA 0.02612 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022858 Css NA 0.1641 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022858 Css NA 0.02198 mg/L PBTK NA 50% Rat Human -DTXSID0022858 Css NA 0.1188 mg/L PBTK NA 95% Rat Human -DTXSID0022933 Clint NA 2376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0022854 TK.Half.Life NA 3.378 hours 1compartment NA NA Rat Human +DTXSID0022854 Css NA 0.05954 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022854 Css NA 0.3353 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022854 Css NA 0.04163 mg/L PBTK NA 50% Rat Human +DTXSID0022854 Css NA 0.2194 mg/L PBTK NA 95% Rat Human +DTXSID0022858 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022858 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022858 Vd NA 2.14 L/kg 1compartment NA NA Human Human +DTXSID0022858 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID0022858 TK.Half.Life NA 56.4 hours 1compartment NA NA Human Human +DTXSID0022858 Css NA 2.216 mg/L 3compartmentss NA 50% Human Human +DTXSID0022858 Css NA 9.687 mg/L 3compartmentss NA 95% Human Human +DTXSID0022858 Css NA 2.074 mg/L PBTK NA 50% Human Human +DTXSID0022858 Css NA 7.081 mg/L PBTK NA 95% Human Human +DTXSID0022858 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022858 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022858 Vd NA 2.142 L/kg 1compartment NA NA Rat Human +DTXSID0022858 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0022858 TK.Half.Life NA 19.21 hours 1compartment NA NA Rat Human +DTXSID0022858 Css NA 0.1381 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022858 Css NA 0.534 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022858 Css NA 0.1321 mg/L PBTK NA 50% Rat Human +DTXSID0022858 Css NA 0.3736 mg/L PBTK NA 95% Rat Human +DTXSID0022933 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0022933 Fup 0.066 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0022933 Vd NA 0.5535 L/kg 1compartment NA NA Human Human -DTXSID0022933 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022933 TK.Half.Life NA 0.5208 hours 1compartment NA NA Human Human -DTXSID0022933 Css NA 0.004422 mg/L 3compartmentss NA 50% Human Human -DTXSID0022933 Css NA 0.03784 mg/L 3compartmentss NA 95% Human Human -DTXSID0022933 Css NA 0.002712 mg/L PBTK NA 50% Human Human -DTXSID0022933 Css NA 0.02249 mg/L PBTK NA 95% Human Human -DTXSID0022933 Clint NA 2376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0022933 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID0022933 TK.Half.Life NA 56.4 hours 1compartment NA NA Human Human +DTXSID0022933 Css NA 14.42 mg/L 3compartmentss NA 50% Human Human +DTXSID0022933 Css NA 64.7 mg/L 3compartmentss NA 95% Human Human +DTXSID0022933 Css NA 8.85 mg/L PBTK NA 50% Human Human +DTXSID0022933 Css NA 37.55 mg/L PBTK NA 95% Human Human +DTXSID0022933 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0022933 Fup 0.066 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0022933 Vd NA 0.4501 L/kg 1compartment NA NA Rat Human -DTXSID0022933 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022933 TK.Half.Life NA 0.1878 hours 1compartment NA NA Rat Human -DTXSID0022933 Css NA 0.002576 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022933 Css NA 0.01815 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022933 Css NA 0.001485 mg/L PBTK NA 50% Rat Human -DTXSID0022933 Css NA 0.01016 mg/L PBTK NA 95% Rat Human -DTXSID0022935 Clint NA 10.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022935 Fup NA 0.7246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022935 Vd NA 1.315 L/kg 1compartment NA NA Human Human -DTXSID0022935 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022935 TK.Half.Life NA 1.333 hours 1compartment NA NA Human Human -DTXSID0022935 Css NA 0.0569 mg/L 3compartmentss NA 50% Human Human -DTXSID0022935 Css NA 0.5652 mg/L 3compartmentss NA 95% Human Human -DTXSID0022935 Css NA 0.05032 mg/L PBTK NA 50% Human Human -DTXSID0022935 Css NA 0.4011 mg/L PBTK NA 95% Human Human -DTXSID0022935 Clint NA 10.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022935 Fup NA 0.7246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022935 Vd NA 1.196 L/kg 1compartment NA NA Rat Human +DTXSID0022933 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0022933 TK.Half.Life NA 15.17 hours 1compartment NA NA Rat Human +DTXSID0022933 Css NA 0.3526 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022933 Css NA 2.096 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022933 Css NA 0.2074 mg/L PBTK NA 50% Rat Human +DTXSID0022933 Css NA 1.198 mg/L PBTK NA 95% Rat Human +DTXSID0022935 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022935 Fup 0.618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022935 Vd NA 1.06 L/kg 1compartment NA NA Human Human +DTXSID0022935 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0022935 TK.Half.Life NA 11.4 hours 1compartment NA NA Human Human +DTXSID0022935 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human +DTXSID0022935 Css NA 7.778 mg/L 3compartmentss NA 95% Human Human +DTXSID0022935 Css NA 0.9478 mg/L PBTK NA 50% Human Human +DTXSID0022935 Css NA 4.968 mg/L PBTK NA 95% Human Human +DTXSID0022935 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022935 Fup 0.618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022935 Vd NA 1.019 L/kg 1compartment NA NA Rat Human DTXSID0022935 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022935 TK.Half.Life NA 0.6107 hours 1compartment NA NA Rat Human -DTXSID0022935 Css NA 0.02775 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022935 Css NA 0.2334 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022935 Css NA 0.02422 mg/L PBTK NA 50% Rat Human -DTXSID0022935 Css NA 0.1535 mg/L PBTK NA 95% Rat Human -DTXSID0022981 Clint NA 4.777 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022981 Fup NA 0.581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0022981 Vd NA 0.4508 L/kg 1compartment NA NA Human Human +DTXSID0022935 TK.Half.Life NA 3.66 hours 1compartment NA NA Rat Human +DTXSID0022935 Css NA 0.0695 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022935 Css NA 0.4613 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022935 Css NA 0.05774 mg/L PBTK NA 50% Rat Human +DTXSID0022935 Css NA 0.2837 mg/L PBTK NA 95% Rat Human +DTXSID0022981 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022981 Fup 0.661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022981 Vd NA 0.4918 L/kg 1compartment NA NA Human Human DTXSID0022981 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0022981 TK.Half.Life NA 0.8225 hours 1compartment NA NA Human Human -DTXSID0022981 Css NA 0.166 mg/L 3compartmentss NA 50% Human Human -DTXSID0022981 Css NA 1.337 mg/L 3compartmentss NA 95% Human Human -DTXSID0022981 Css NA 0.1194 mg/L PBTK NA 50% Human Human -DTXSID0022981 Css NA 0.841 mg/L PBTK NA 95% Human Human -DTXSID0022981 Clint NA 4.777 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022981 Fup NA 0.581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0022981 Vd NA 0.4615 L/kg 1compartment NA NA Rat Human +DTXSID0022981 TK.Half.Life NA 4.817 hours 1compartment NA NA Human Human +DTXSID0022981 Css NA 1.201 mg/L 3compartmentss NA 50% Human Human +DTXSID0022981 Css NA 7.308 mg/L 3compartmentss NA 95% Human Human +DTXSID0022981 Css NA 0.8917 mg/L PBTK NA 50% Human Human +DTXSID0022981 Css NA 4.494 mg/L PBTK NA 95% Human Human +DTXSID0022981 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022981 Fup 0.661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022981 Vd NA 0.5025 L/kg 1compartment NA NA Rat Human DTXSID0022981 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0022981 TK.Half.Life NA 0.4539 hours 1compartment NA NA Rat Human -DTXSID0022981 Css NA 0.07977 mg/L 3compartmentss NA 50% Rat Human -DTXSID0022981 Css NA 0.5553 mg/L 3compartmentss NA 95% Rat Human -DTXSID0022981 Css NA 0.05522 mg/L PBTK NA 50% Rat Human -DTXSID0022981 Css NA 0.3196 mg/L PBTK NA 95% Rat Human -DTXSID0023030 Clint NA 7.509 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023030 Fup NA 0.0526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023030 Vd NA 1.254 L/kg 1compartment NA NA Human Human -DTXSID0023030 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0023030 TK.Half.Life NA 12.98 hours 1compartment NA NA Human Human -DTXSID0023030 Css NA 1.645 mg/L 3compartmentss NA 50% Human Human -DTXSID0023030 Css NA 11.28 mg/L 3compartmentss NA 95% Human Human -DTXSID0023030 Css NA 1.044 mg/L PBTK NA 50% Human Human -DTXSID0023030 Css NA 6.835 mg/L PBTK NA 95% Human Human -DTXSID0023030 Clint NA 7.509 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023030 Fup NA 0.0526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023030 Vd NA 0.9606 L/kg 1compartment NA NA Rat Human +DTXSID0022981 TK.Half.Life NA 1.676 hours 1compartment NA NA Rat Human +DTXSID0022981 Css NA 0.07328 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022981 Css NA 0.4247 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022981 Css NA 0.05382 mg/L PBTK NA 50% Rat Human +DTXSID0022981 Css NA 0.2534 mg/L PBTK NA 95% Rat Human +DTXSID0022983 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID0022983 Fup 0.26 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0022983 Vd NA 2.995 L/kg 1compartment NA NA Human Human +DTXSID0022983 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0022983 TK.Half.Life NA 31.52 hours 1compartment NA NA Human Human +DTXSID0022983 Css NA 1.154 mg/L 3compartmentss NA 50% Human Human +DTXSID0022983 Css NA 6.73 mg/L 3compartmentss NA 95% Human Human +DTXSID0022983 Css NA 0.8272 mg/L PBTK NA 50% Human Human +DTXSID0022983 Css NA 4.635 mg/L PBTK NA 95% Human Human +DTXSID0022983 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID0022983 Fup 0.26 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0022983 Vd NA 2.262 L/kg 1compartment NA NA Rat Human +DTXSID0022983 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0022983 TK.Half.Life NA 5.316 hours 1compartment NA NA Rat Human +DTXSID0022983 Css NA 0.1431 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022983 Css NA 0.6106 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022983 Css NA 0.102 mg/L PBTK NA 50% Rat Human +DTXSID0022983 Css NA 0.4251 mg/L PBTK NA 95% Rat Human +DTXSID0022985 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022985 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022985 Vd NA 2.976 L/kg 1compartment NA NA Human Human +DTXSID0022985 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0022985 TK.Half.Life NA 3.866 hours 1compartment NA NA Human Human +DTXSID0022985 Css NA 0.07443 mg/L 3compartmentss NA 50% Human Human +DTXSID0022985 Css NA 0.8232 mg/L 3compartmentss NA 95% Human Human +DTXSID0022985 Css NA 0.08662 mg/L PBTK NA 50% Human Human +DTXSID0022985 Css NA 0.6669 mg/L PBTK NA 95% Human Human +DTXSID0022985 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022985 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022985 Vd 6.8 3.002 L/kg 1compartment National Toxicology Program NA Rat Human +DTXSID0022985 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0022985 TK.Half.Life 1.2 2.21 hours 1compartment National Toxicology Program NA Rat Human +DTXSID0022985 Css 0.01 0.007678 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID0022985 Css 0.01 0.07858 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID0022985 Css 0.01 0.009469 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID0022985 Css 0.01 0.05668 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID0022987 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022987 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0022987 Vd NA 1.281 L/kg 1compartment NA NA Human Human +DTXSID0022987 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID0022987 TK.Half.Life NA 33.7 hours 1compartment NA NA Human Human +DTXSID0022987 Css NA 1.451 mg/L 3compartmentss NA 50% Human Human +DTXSID0022987 Css NA 6.318 mg/L 3compartmentss NA 95% Human Human +DTXSID0022987 Css NA 1.148 mg/L PBTK NA 50% Human Human +DTXSID0022987 Css NA 4.182 mg/L PBTK NA 95% Human Human +DTXSID0022987 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022987 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0022987 Vd NA 1.259 L/kg 1compartment NA NA Rat Human +DTXSID0022987 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0022987 TK.Half.Life NA 11.15 hours 1compartment NA NA Rat Human +DTXSID0022987 Css NA 0.007783 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022987 Css NA 0.03437 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022987 Css NA 0.005896 mg/L PBTK NA 50% Rat Human +DTXSID0022987 Css NA 0.02218 mg/L PBTK NA 95% Rat Human +DTXSID0022989 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0022989 Fup 0.017 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0022989 Vd NA 1.161 L/kg 1compartment NA NA Human Human +DTXSID0022989 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0022989 TK.Half.Life NA 11.72 hours 1compartment NA NA Human Human +DTXSID0022989 Css NA 1.414 mg/L 3compartmentss NA 50% Human Human +DTXSID0022989 Css NA 13.96 mg/L 3compartmentss NA 95% Human Human +DTXSID0022989 Css NA 0.8672 mg/L PBTK NA 50% Human Human +DTXSID0022989 Css NA 8.285 mg/L PBTK NA 95% Human Human +DTXSID0022989 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0022989 Fup 0.017 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0022989 Vd NA 0.8582 L/kg 1compartment NA NA Rat Human +DTXSID0022989 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0022989 TK.Half.Life NA 4.933 hours 1compartment NA NA Rat Human +DTXSID0022989 Css NA 0.0722 mg/L 3compartmentss NA 50% Rat Human +DTXSID0022989 Css NA 0.7308 mg/L 3compartmentss NA 95% Rat Human +DTXSID0022989 Css NA 0.04254 mg/L PBTK NA 50% Rat Human +DTXSID0022989 Css NA 0.417 mg/L PBTK NA 95% Rat Human +DTXSID0023030 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023030 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023030 Vd NA 1.945 L/kg 1compartment NA NA Human Human +DTXSID0023030 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0023030 TK.Half.Life NA 7.866 hours 1compartment NA NA Human Human +DTXSID0023030 Css NA 0.4856 mg/L 3compartmentss NA 50% Human Human +DTXSID0023030 Css NA 3.28 mg/L 3compartmentss NA 95% Human Human +DTXSID0023030 Css NA 0.3238 mg/L PBTK NA 50% Human Human +DTXSID0023030 Css NA 2.069 mg/L PBTK NA 95% Human Human +DTXSID0023030 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023030 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023030 Vd NA 1.477 L/kg 1compartment NA NA Rat Human DTXSID0023030 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023030 TK.Half.Life NA 5.419 hours 1compartment NA NA Rat Human -DTXSID0023030 Css NA 0.8859 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023030 Css NA 4.383 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023030 Css NA 0.5294 mg/L PBTK NA 50% Rat Human -DTXSID0023030 Css NA 2.486 mg/L PBTK NA 95% Rat Human -DTXSID0023032 Clint NA 4.516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023032 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023032 Vd NA 1.159 L/kg 1compartment NA NA Human Human -DTXSID0023032 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0023032 TK.Half.Life NA 22.95 hours 1compartment NA NA Human Human -DTXSID0023032 Css NA 3.359 mg/L 3compartmentss NA 50% Human Human -DTXSID0023032 Css NA 23.31 mg/L 3compartmentss NA 95% Human Human -DTXSID0023032 Css NA 2.11 mg/L PBTK NA 50% Human Human -DTXSID0023032 Css NA 13.77 mg/L PBTK NA 95% Human Human -DTXSID0023032 Clint NA 4.516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023032 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023032 Vd NA 0.8738 L/kg 1compartment NA NA Rat Human -DTXSID0023032 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0023032 TK.Half.Life NA 9.322 hours 1compartment NA NA Rat Human -DTXSID0023032 Css NA 1.753 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023032 Css NA 9.761 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023032 Css NA 1.026 mg/L PBTK NA 50% Rat Human -DTXSID0023032 Css NA 5.421 mg/L PBTK NA 95% Rat Human -DTXSID0023036 Clint NA 512.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023036 Fup NA 0.0086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023036 Vd NA 4.103 L/kg 1compartment NA NA Human Human -DTXSID0023036 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023036 TK.Half.Life NA 8.236 hours 1compartment NA NA Human Human -DTXSID0023036 Css NA 0.1387 mg/L 3compartmentss NA 50% Human Human -DTXSID0023036 Css NA 0.7751 mg/L 3compartmentss NA 95% Human Human -DTXSID0023036 Css NA 0.1046 mg/L PBTK NA 50% Human Human -DTXSID0023036 Css NA 0.57 mg/L PBTK NA 95% Human Human -DTXSID0023036 Clint NA 512.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023036 Fup NA 0.0086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023036 Vd NA 3.107 L/kg 1compartment NA NA Rat Human -DTXSID0023036 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023036 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human -DTXSID0023036 Css NA 0.07806 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023036 Css NA 0.3487 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023036 Css NA 0.05652 mg/L PBTK NA 50% Rat Human -DTXSID0023036 Css NA 0.2559 mg/L PBTK NA 95% Rat Human -DTXSID0023038 Clint NA 10.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023038 Fup NA 0.4281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023038 Vd NA 0.3535 L/kg 1compartment NA NA Human Human -DTXSID0023038 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023038 TK.Half.Life NA 0.5471 hours 1compartment NA NA Human Human -DTXSID0023038 Css NA 0.11 mg/L 3compartmentss NA 50% Human Human -DTXSID0023038 Css NA 0.761 mg/L 3compartmentss NA 95% Human Human -DTXSID0023038 Css NA 0.07476 mg/L PBTK NA 50% Human Human -DTXSID0023038 Css NA 0.494 mg/L PBTK NA 95% Human Human -DTXSID0023038 Clint NA 10.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023038 Fup NA 0.4281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023038 Vd NA 0.3637 L/kg 1compartment NA NA Rat Human +DTXSID0023030 TK.Half.Life NA 2.696 hours 1compartment NA NA Rat Human +DTXSID0023030 Css NA 0.0621 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023030 Css NA 0.344 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023030 Css NA 0.04066 mg/L PBTK NA 50% Rat Human +DTXSID0023030 Css NA 0.2133 mg/L PBTK NA 95% Rat Human +DTXSID0023032 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023032 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023032 Vd NA 1.167 L/kg 1compartment NA NA Human Human +DTXSID0023032 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0023032 TK.Half.Life NA 3.045 hours 1compartment NA NA Human Human +DTXSID0023032 Css NA 0.2779 mg/L 3compartmentss NA 50% Human Human +DTXSID0023032 Css NA 2.159 mg/L 3compartmentss NA 95% Human Human +DTXSID0023032 Css NA 0.181 mg/L PBTK NA 50% Human Human +DTXSID0023032 Css NA 1.342 mg/L PBTK NA 95% Human Human +DTXSID0023032 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023032 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023032 Vd NA 0.9085 L/kg 1compartment NA NA Rat Human +DTXSID0023032 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0023032 TK.Half.Life NA 1.281 hours 1compartment NA NA Rat Human +DTXSID0023032 Css NA 0.03556 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023032 Css NA 0.217 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023032 Css NA 0.02274 mg/L PBTK NA 50% Rat Human +DTXSID0023032 Css NA 0.1307 mg/L PBTK NA 95% Rat Human +DTXSID0023036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023036 Fup 0.0114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023036 Vd NA 4.968 L/kg 1compartment NA NA Human Human +DTXSID0023036 Days.Css NA 27 Days PBTK NA NA Human Human +DTXSID0023036 TK.Half.Life NA 150 hours 1compartment NA NA Human Human +DTXSID0023036 Css NA 2.939 mg/L 3compartmentss NA 50% Human Human +DTXSID0023036 Css NA 17.66 mg/L 3compartmentss NA 95% Human Human +DTXSID0023036 Css NA 2.386 mg/L PBTK NA 50% Human Human +DTXSID0023036 Css NA 14.06 mg/L PBTK NA 95% Human Human +DTXSID0023036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023036 Fup 0.0114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023036 Vd NA 3.792 L/kg 1compartment NA NA Rat Human +DTXSID0023036 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID0023036 TK.Half.Life NA 20.57 hours 1compartment NA NA Rat Human +DTXSID0023036 Css NA 0.3808 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023036 Css NA 1.954 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023036 Css NA 0.3088 mg/L PBTK NA 50% Rat Human +DTXSID0023036 Css NA 1.582 mg/L PBTK NA 95% Rat Human +DTXSID0023038 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023038 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023038 Vd NA 1.404 L/kg 1compartment NA NA Human Human +DTXSID0023038 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0023038 TK.Half.Life NA 16.53 hours 1compartment NA NA Human Human +DTXSID0023038 Css NA 1.166 mg/L 3compartmentss NA 50% Human Human +DTXSID0023038 Css NA 8.281 mg/L 3compartmentss NA 95% Human Human +DTXSID0023038 Css NA 1.025 mg/L PBTK NA 50% Human Human +DTXSID0023038 Css NA 5.315 mg/L PBTK NA 95% Human Human +DTXSID0023038 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023038 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023038 Vd NA 1.237 L/kg 1compartment NA NA Rat Human DTXSID0023038 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023038 TK.Half.Life NA 0.3023 hours 1compartment NA NA Rat Human -DTXSID0023038 Css NA 0.05661 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023038 Css NA 0.3089 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023038 Css NA 0.0367 mg/L PBTK NA 50% Rat Human -DTXSID0023038 Css NA 0.1838 mg/L PBTK NA 95% Rat Human -DTXSID0023084 Clint NA 64.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023084 Fup NA 0.1881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023084 Vd NA 1.635 L/kg 1compartment NA NA Human Human +DTXSID0023038 TK.Half.Life NA 4.495 hours 1compartment NA NA Rat Human +DTXSID0023038 Css NA 0.07118 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023038 Css NA 0.4406 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023038 Css NA 0.06258 mg/L PBTK NA 50% Rat Human +DTXSID0023038 Css NA 0.2784 mg/L PBTK NA 95% Rat Human +DTXSID00230663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00230663 Fup 0.0011 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00230663 Vd NA 0.6973 L/kg 1compartment NA NA Human Human +DTXSID00230663 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID00230663 TK.Half.Life NA 55.81 hours 1compartment NA NA Human Human +DTXSID00230663 Css NA 12.79 mg/L 3compartmentss NA 50% Human Human +DTXSID00230663 Css NA 119.3 mg/L 3compartmentss NA 95% Human Human +DTXSID00230663 Css NA 7.53 mg/L PBTK NA 50% Human Human +DTXSID00230663 Css NA 70.8 mg/L PBTK NA 95% Human Human +DTXSID00230663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00230663 Fup 0.0011 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00230663 Vd NA 0.5121 L/kg 1compartment NA NA Rat Human +DTXSID00230663 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID00230663 TK.Half.Life NA 26.51 hours 1compartment NA NA Rat Human +DTXSID00230663 Css NA 0.6587 mg/L 3compartmentss NA 50% Rat Human +DTXSID00230663 Css NA 6.893 mg/L 3compartmentss NA 95% Rat Human +DTXSID00230663 Css NA 0.3712 mg/L PBTK NA 50% Rat Human +DTXSID00230663 Css NA 3.834 mg/L PBTK NA 95% Rat Human +DTXSID0023080 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023080 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0023080 Vd NA 2.29 L/kg 1compartment NA NA Human Human +DTXSID0023080 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0023080 TK.Half.Life NA 2.341 hours 1compartment NA NA Human Human +DTXSID0023080 Css NA 0.06544 mg/L 3compartmentss NA 50% Human Human +DTXSID0023080 Css NA 0.6164 mg/L 3compartmentss NA 95% Human Human +DTXSID0023080 Css NA 0.06976 mg/L PBTK NA 50% Human Human +DTXSID0023080 Css NA 0.4948 mg/L PBTK NA 95% Human Human +DTXSID0023080 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023080 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0023080 Vd NA 2.278 L/kg 1compartment NA NA Rat Human +DTXSID0023080 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0023080 TK.Half.Life NA 1.268 hours 1compartment NA NA Rat Human +DTXSID0023080 Css NA 0.006969 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023080 Css NA 0.05765 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023080 Css NA 0.007833 mg/L PBTK NA 50% Rat Human +DTXSID0023080 Css NA 0.04342 mg/L PBTK NA 95% Rat Human +DTXSID0023084 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023084 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023084 Vd NA 1.726 L/kg 1compartment NA NA Human Human DTXSID0023084 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023084 TK.Half.Life NA 1.73 hours 1compartment NA NA Human Human -DTXSID0023084 Css NA 0.03966 mg/L 3compartmentss NA 50% Human Human -DTXSID0023084 Css NA 0.3012 mg/L 3compartmentss NA 95% Human Human -DTXSID0023084 Css NA 0.03024 mg/L PBTK NA 50% Human Human -DTXSID0023084 Css NA 0.2091 mg/L PBTK NA 95% Human Human -DTXSID0023084 Clint NA 64.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023084 Fup NA 0.1881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023084 Vd NA 1.444 L/kg 1compartment NA NA Rat Human +DTXSID0023084 TK.Half.Life NA 5.255 hours 1compartment NA NA Human Human +DTXSID0023084 Css NA 0.2265 mg/L 3compartmentss NA 50% Human Human +DTXSID0023084 Css NA 1.448 mg/L 3compartmentss NA 95% Human Human +DTXSID0023084 Css NA 0.1808 mg/L PBTK NA 50% Human Human +DTXSID0023084 Css NA 1.04 mg/L PBTK NA 95% Human Human +DTXSID0023084 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023084 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023084 Vd NA 1.559 L/kg 1compartment NA NA Rat Human DTXSID0023084 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023084 TK.Half.Life NA 0.7475 hours 1compartment NA NA Rat Human -DTXSID0023084 Css NA 0.02212 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023084 Css NA 0.1279 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023084 Css NA 0.01616 mg/L PBTK NA 50% Rat Human -DTXSID0023084 Css NA 0.08756 mg/L PBTK NA 95% Rat Human +DTXSID0023084 TK.Half.Life NA 2.563 hours 1compartment NA NA Rat Human +DTXSID0023084 Css NA 0.009894 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023084 Css NA 0.07493 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023084 Css NA 0.008001 mg/L PBTK NA 50% Rat Human +DTXSID0023084 Css NA 0.05259 mg/L PBTK NA 95% Rat Human DTXSID0023088 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0023088 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0023088 Vd NA 0.5386 L/kg 1compartment NA NA Human Human DTXSID0023088 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0023088 TK.Half.Life NA 3.487 hours 1compartment NA NA Human Human -DTXSID0023088 Css NA 0.9116 mg/L 3compartmentss NA 50% Human Human -DTXSID0023088 Css NA 5.669 mg/L 3compartmentss NA 95% Human Human -DTXSID0023088 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID0023088 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID0023088 Css NA 0.7688 mg/L 3compartmentss NA 50% Human Human +DTXSID0023088 Css NA 5.209 mg/L 3compartmentss NA 95% Human Human +DTXSID0023088 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID0023088 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID0023088 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0023088 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0023088 Vd NA 0.5791 L/kg 1compartment NA NA Rat Human DTXSID0023088 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0023088 TK.Half.Life NA 1.277 hours 1compartment NA NA Rat Human -DTXSID0023088 Css NA 0.2312 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023088 Css NA 1.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023088 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0023088 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID0023088 Css NA 0.0142 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023088 Css NA 0.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023088 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID0023088 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID0023111 Clint 7.009 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0023111 Fup 0.35 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0023111 Vd NA 3.582 L/kg 1compartment NA NA Human Human +DTXSID0023111 Vd NA 3.515 L/kg 1compartment NA NA Human Human DTXSID0023111 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023111 TK.Half.Life NA 7.485 hours 1compartment NA NA Human Human -DTXSID0023111 Css NA 0.1674 mg/L 3compartmentss NA 50% Human Human -DTXSID0023111 Css NA 1.1 mg/L 3compartmentss NA 95% Human Human -DTXSID0023111 Css NA 0.1357 mg/L PBTK NA 50% Human Human -DTXSID0023111 Css NA 0.7826 mg/L PBTK NA 95% Human Human +DTXSID0023111 TK.Half.Life NA 7.284 hours 1compartment NA NA Human Human +DTXSID0023111 Css NA 0.1509 mg/L 3compartmentss NA 50% Human Human +DTXSID0023111 Css NA 0.8448 mg/L 3compartmentss NA 95% Human Human +DTXSID0023111 Css NA 0.1293 mg/L PBTK NA 50% Human Human +DTXSID0023111 Css NA 0.7254 mg/L PBTK NA 95% Human Human DTXSID0023111 Clint 62.92 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID0023111 Fup 0.61 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID0023111 Vd NA 4.813 L/kg 1compartment NA NA Rat Rat +DTXSID0023111 Vd NA 4.772 L/kg 1compartment NA NA Rat Rat DTXSID0023111 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID0023111 TK.Half.Life NA 1.551 hours 1compartment NA NA Rat Rat -DTXSID0023111 Css NA 0.007777 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0023111 Css NA 0.0673 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0023111 Css NA 0.005799 mg/L PBTK NA 50% Rat Rat -DTXSID0023111 Css NA 0.04384 mg/L PBTK NA 95% Rat Rat +DTXSID0023111 TK.Half.Life NA 1.538 hours 1compartment NA NA Rat Rat +DTXSID0023111 Css NA 0.001332 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0023111 Css NA 0.01119 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0023111 Css NA 0.001191 mg/L PBTK NA 50% Rat Rat +DTXSID0023111 Css NA 0.009965 mg/L PBTK NA 95% Rat Rat DTXSID0023113 Clint 44.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0023113 Fup 0.569 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0023113 Vd NA 1.177 L/kg 1compartment NA NA Human Human DTXSID0023113 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0023113 TK.Half.Life NA 0.9004 hours 1compartment NA NA Human Human -DTXSID0023113 Css NA 0.01548 mg/L 3compartmentss NA 50% Human Human -DTXSID0023113 Css NA 0.09773 mg/L 3compartmentss NA 95% Human Human -DTXSID0023113 Css NA 0.01323 mg/L PBTK NA 50% Human Human -DTXSID0023113 Css NA 0.07631 mg/L PBTK NA 95% Human Human +DTXSID0023113 Css NA 0.01346 mg/L 3compartmentss NA 50% Human Human +DTXSID0023113 Css NA 0.09613 mg/L 3compartmentss NA 95% Human Human +DTXSID0023113 Css NA 0.01147 mg/L PBTK NA 50% Human Human +DTXSID0023113 Css NA 0.0781 mg/L PBTK NA 95% Human Human DTXSID0023113 Clint 44.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0023113 Fup 0.569 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0023113 Vd NA 1.056 L/kg 1compartment NA NA Rat Human DTXSID0023113 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0023113 TK.Half.Life NA 0.3781 hours 1compartment NA NA Rat Human -DTXSID0023113 Css NA 0.008265 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023113 Css NA 0.04277 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023113 Css NA 0.006884 mg/L PBTK NA 50% Rat Human -DTXSID0023113 Css NA 0.03325 mg/L PBTK NA 95% Rat Human -DTXSID0023163 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0023113 Css NA 0.001686 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023113 Css NA 0.009593 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023113 Css NA 0.001474 mg/L PBTK NA 50% Rat Human +DTXSID0023113 Css NA 0.007844 mg/L PBTK NA 95% Rat Human +DTXSID0023163 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0023163 Fup 0.99 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0023163 Vd NA 0.6424 L/kg 1compartment NA NA Human Human DTXSID0023163 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0023163 TK.Half.Life NA 4.196 hours 1compartment NA NA Human Human -DTXSID0023163 Css NA 0.9096 mg/L 3compartmentss NA 50% Human Human -DTXSID0023163 Css NA 5.071 mg/L 3compartmentss NA 95% Human Human -DTXSID0023163 Css NA 0.722 mg/L PBTK NA 50% Human Human -DTXSID0023163 Css NA 3.277 mg/L PBTK NA 95% Human Human -DTXSID0023163 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0023163 Css NA 0.4998 mg/L 3compartmentss NA 50% Human Human +DTXSID0023163 Css NA 2.901 mg/L 3compartmentss NA 95% Human Human +DTXSID0023163 Css NA 0.3975 mg/L PBTK NA 50% Human Human +DTXSID0023163 Css NA 1.862 mg/L PBTK NA 95% Human Human +DTXSID0023163 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0023163 Fup 0.99 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0023163 Vd NA 0.6848 L/kg 1compartment NA NA Rat Human DTXSID0023163 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0023163 TK.Half.Life NA 1.525 hours 1compartment NA NA Rat Human -DTXSID0023163 Css NA 0.232 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023163 Css NA 1.273 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023163 Css NA 0.1792 mg/L PBTK NA 50% Rat Human -DTXSID0023163 Css NA 0.7575 mg/L PBTK NA 95% Rat Human +DTXSID0023163 Css NA 0.002578 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023163 Css NA 0.01653 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023163 Css NA 0.001988 mg/L PBTK NA 50% Rat Human +DTXSID0023163 Css NA 0.01021 mg/L PBTK NA 95% Rat Human DTXSID0023169 Clint 13.63 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0023169 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0023169 Vd NA 2.115 L/kg 1compartment NA NA Human Human -DTXSID0023169 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023169 TK.Half.Life NA 10.81 hours 1compartment NA NA Human Human -DTXSID0023169 Css NA 0.5902 mg/L 3compartmentss NA 50% Human Human -DTXSID0023169 Css NA 3.717 mg/L 3compartmentss NA 95% Human Human -DTXSID0023169 Css NA 0.3615 mg/L PBTK NA 50% Human Human -DTXSID0023169 Css NA 2.2 mg/L PBTK NA 95% Human Human +DTXSID0023169 Vd NA 3.124 L/kg 1compartment NA NA Human Human +DTXSID0023169 Days.Css NA 19 Days PBTK NA NA Human Human +DTXSID0023169 TK.Half.Life NA 113.4 hours 1compartment NA NA Human Human +DTXSID0023169 Css NA 4.674 mg/L 3compartmentss NA 50% Human Human +DTXSID0023169 Css NA 29.97 mg/L 3compartmentss NA 95% Human Human +DTXSID0023169 Css NA 2.991 mg/L PBTK NA 50% Human Human +DTXSID0023169 Css NA 19.18 mg/L PBTK NA 95% Human Human DTXSID0023169 Clint 13.63 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID0023169 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0023169 Vd NA 1.593 L/kg 1compartment NA NA Rat Human -DTXSID0023169 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023169 TK.Half.Life NA 3.34 hours 1compartment NA NA Rat Human -DTXSID0023169 Css NA 0.3898 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023169 Css NA 1.849 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023169 Css NA 0.2236 mg/L PBTK NA 50% Rat Human -DTXSID0023169 Css NA 1.041 mg/L PBTK NA 95% Rat Human +DTXSID0023169 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID0023169 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID0023169 TK.Half.Life NA 15.05 hours 1compartment NA NA Rat Human +DTXSID0023169 Css NA 0.5757 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023169 Css NA 3.238 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023169 Css NA 0.3814 mg/L PBTK NA 50% Rat Human +DTXSID0023169 Css NA 2.147 mg/L PBTK NA 95% Rat Human +DTXSID0023240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023240 Fup 0.477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023240 Vd NA 3.837 L/kg 1compartment NA NA Human Human +DTXSID0023240 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0023240 TK.Half.Life NA 2.547 hours 1compartment NA NA Human Human +DTXSID0023240 Css NA 0.0191 mg/L 3compartmentss NA 50% Human Human +DTXSID0023240 Css NA 0.216 mg/L 3compartmentss NA 95% Human Human +DTXSID0023240 Css NA 0.02665 mg/L PBTK NA 50% Human Human +DTXSID0023240 Css NA 0.21 mg/L PBTK NA 95% Human Human +DTXSID0023240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023240 Fup 0.477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023240 Vd NA 3.85 L/kg 1compartment NA NA Rat Human +DTXSID0023240 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0023240 TK.Half.Life NA 1.384 hours 1compartment NA NA Rat Human +DTXSID0023240 Css NA 0.002238 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023240 Css NA 0.02145 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023240 Css NA 0.003313 mg/L PBTK NA 50% Rat Human +DTXSID0023240 Css NA 0.0209 mg/L PBTK NA 95% Rat Human DTXSID0023244 Clint NA 0.6141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0023244 Fup NA 0.998 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023244 Vd NA 1.275 L/kg 1compartment NA NA Human Human +DTXSID0023244 Vd NA 1.324 L/kg 1compartment NA NA Human Human DTXSID0023244 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023244 TK.Half.Life NA 4.211 hours 1compartment NA NA Human Human -DTXSID0023244 Css NA 0.3756 mg/L 3compartmentss NA 50% Human Human -DTXSID0023244 Css NA 2.638 mg/L 3compartmentss NA 95% Human Human -DTXSID0023244 Css NA 0.348 mg/L PBTK NA 50% Human Human -DTXSID0023244 Css NA 1.751 mg/L PBTK NA 95% Human Human +DTXSID0023244 TK.Half.Life NA 4.387 hours 1compartment NA NA Human Human +DTXSID0023244 Css NA 0.3137 mg/L 3compartmentss NA 50% Human Human +DTXSID0023244 Css NA 2.245 mg/L 3compartmentss NA 95% Human Human +DTXSID0023244 Css NA 0.2944 mg/L PBTK NA 50% Human Human +DTXSID0023244 Css NA 1.499 mg/L PBTK NA 95% Human Human DTXSID0023244 Clint NA 0.6141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0023244 Fup NA 0.998 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023244 Vd NA 1.317 L/kg 1compartment NA NA Rat Human +DTXSID0023244 Vd NA 1.363 L/kg 1compartment NA NA Rat Human DTXSID0023244 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023244 TK.Half.Life NA 1.964 hours 1compartment NA NA Rat Human -DTXSID0023244 Css NA 0.1261 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023244 Css NA 0.8361 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023244 Css NA 0.1178 mg/L PBTK NA 50% Rat Human -DTXSID0023244 Css NA 0.5268 mg/L PBTK NA 95% Rat Human -DTXSID0023292 Clint NA 49.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023292 Fup NA 0.54 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023292 Vd NA 2.922 L/kg 1compartment NA NA Human Human +DTXSID0023244 TK.Half.Life NA 2.037 hours 1compartment NA NA Rat Human +DTXSID0023244 Css NA 0.007699 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023244 Css NA 0.06597 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023244 Css NA 0.007126 mg/L PBTK NA 50% Rat Human +DTXSID0023244 Css NA 0.04514 mg/L PBTK NA 95% Rat Human +DTXSID0023292 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023292 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023292 Vd NA 2.557 L/kg 1compartment NA NA Human Human DTXSID0023292 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023292 TK.Half.Life NA 1.615 hours 1compartment NA NA Human Human -DTXSID0023292 Css NA 0.01097 mg/L 3compartmentss NA 50% Human Human -DTXSID0023292 Css NA 0.1297 mg/L 3compartmentss NA 95% Human Human -DTXSID0023292 Css NA 0.0131 mg/L PBTK NA 50% Human Human -DTXSID0023292 Css NA 0.1093 mg/L PBTK NA 95% Human Human -DTXSID0023292 Clint NA 49.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023292 Fup NA 0.54 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023292 Vd NA 2.922 L/kg 1compartment NA NA Rat Human +DTXSID0023292 TK.Half.Life NA 2.082 hours 1compartment NA NA Human Human +DTXSID0023292 Css NA 0.02849 mg/L 3compartmentss NA 50% Human Human +DTXSID0023292 Css NA 0.2727 mg/L 3compartmentss NA 95% Human Human +DTXSID0023292 Css NA 0.0318 mg/L PBTK NA 50% Human Human +DTXSID0023292 Css NA 0.2269 mg/L PBTK NA 95% Human Human +DTXSID0023292 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023292 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023292 Vd NA 2.551 L/kg 1compartment NA NA Rat Human DTXSID0023292 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023292 TK.Half.Life NA 0.7921 hours 1compartment NA NA Rat Human -DTXSID0023292 Css NA 0.005718 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023292 Css NA 0.05975 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023292 Css NA 0.006802 mg/L PBTK NA 50% Rat Human -DTXSID0023292 Css NA 0.04931 mg/L PBTK NA 95% Rat Human -DTXSID0023294 Clint NA 620.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023294 Fup NA 0.1522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023294 Vd NA 0.8169 L/kg 1compartment NA NA Human Human -DTXSID0023294 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023294 TK.Half.Life NA 0.7114 hours 1compartment NA NA Human Human -DTXSID0023294 Css NA 0.006181 mg/L 3compartmentss NA 50% Human Human -DTXSID0023294 Css NA 0.05214 mg/L 3compartmentss NA 95% Human Human -DTXSID0023294 Css NA 0.004108 mg/L PBTK NA 50% Human Human -DTXSID0023294 Css NA 0.0328 mg/L PBTK NA 95% Human Human -DTXSID0023294 Clint NA 620.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023294 Fup NA 0.1522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023294 Vd NA 0.6846 L/kg 1compartment NA NA Rat Human +DTXSID0023292 TK.Half.Life NA 1.109 hours 1compartment NA NA Rat Human +DTXSID0023292 Css NA 0.00336 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023292 Css NA 0.02662 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023292 Css NA 0.003858 mg/L PBTK NA 50% Rat Human +DTXSID0023292 Css NA 0.02237 mg/L PBTK NA 95% Rat Human +DTXSID0023294 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023294 Fup 0.598 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023294 Vd NA 1.702 L/kg 1compartment NA NA Human Human +DTXSID0023294 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0023294 TK.Half.Life NA 23.43 hours 1compartment NA NA Human Human +DTXSID0023294 Css NA 1.18 mg/L 3compartmentss NA 50% Human Human +DTXSID0023294 Css NA 7.598 mg/L 3compartmentss NA 95% Human Human +DTXSID0023294 Css NA 1.03 mg/L PBTK NA 50% Human Human +DTXSID0023294 Css NA 5.064 mg/L PBTK NA 95% Human Human +DTXSID0023294 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023294 Fup 0.598 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023294 Vd NA 1.447 L/kg 1compartment NA NA Rat Human DTXSID0023294 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023294 TK.Half.Life NA 0.266 hours 1compartment NA NA Rat Human -DTXSID0023294 Css NA 0.003547 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023294 Css NA 0.0236 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023294 Css NA 0.002236 mg/L PBTK NA 50% Rat Human -DTXSID0023294 Css NA 0.01409 mg/L PBTK NA 95% Rat Human +DTXSID0023294 TK.Half.Life NA 5.682 hours 1compartment NA NA Rat Human +DTXSID0023294 Css NA 0.02964 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023294 Css NA 0.2296 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023294 Css NA 0.02614 mg/L PBTK NA 50% Rat Human +DTXSID0023294 Css NA 0.1522 mg/L PBTK NA 95% Rat Human DTXSID0023296 Clint 13.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0023296 Fup 0.38 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0023296 Vd NA 3.048 L/kg 1compartment NA NA Human Human -DTXSID0023296 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0023296 TK.Half.Life NA 20.43 hours 1compartment NA NA Human Human -DTXSID0023296 Css NA 0.7004 mg/L 3compartmentss NA 50% Human Human -DTXSID0023296 Css NA 3.959 mg/L 3compartmentss NA 95% Human Human -DTXSID0023296 Css NA 0.508 mg/L PBTK NA 50% Human Human -DTXSID0023296 Css NA 2.777 mg/L PBTK NA 95% Human Human +DTXSID0023296 Vd NA 2.141 L/kg 1compartment NA NA Human Human +DTXSID0023296 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0023296 TK.Half.Life NA 3.819 hours 1compartment NA NA Human Human +DTXSID0023296 Css NA 0.1085 mg/L 3compartmentss NA 50% Human Human +DTXSID0023296 Css NA 0.6655 mg/L 3compartmentss NA 95% Human Human +DTXSID0023296 Css NA 0.08685 mg/L PBTK NA 50% Human Human +DTXSID0023296 Css NA 0.4971 mg/L PBTK NA 95% Human Human DTXSID0023296 Clint 13.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0023296 Fup 0.38 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0023296 Vd NA 2.305 L/kg 1compartment NA NA Rat Human -DTXSID0023296 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0023296 TK.Half.Life NA 3.455 hours 1compartment NA NA Rat Human -DTXSID0023296 Css NA 0.3794 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023296 Css NA 1.733 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023296 Css NA 0.2643 mg/L PBTK NA 50% Rat Human -DTXSID0023296 Css NA 1.176 mg/L PBTK NA 95% Rat Human -DTXSID0023298 Clint NA 21.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023298 Fup NA 0.2463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023298 Vd NA 2.996 L/kg 1compartment NA NA Human Human +DTXSID0023296 Vd NA 1.687 L/kg 1compartment NA NA Rat Human +DTXSID0023296 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0023296 TK.Half.Life NA 1.287 hours 1compartment NA NA Rat Human +DTXSID0023296 Css NA 0.009028 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023296 Css NA 0.04254 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023296 Css NA 0.007335 mg/L PBTK NA 50% Rat Human +DTXSID0023296 Css NA 0.03125 mg/L PBTK NA 95% Rat Human +DTXSID0023298 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023298 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023298 Vd NA 3.135 L/kg 1compartment NA NA Human Human DTXSID0023298 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023298 TK.Half.Life NA 5.786 hours 1compartment NA NA Human Human -DTXSID0023298 Css NA 0.139 mg/L 3compartmentss NA 50% Human Human -DTXSID0023298 Css NA 0.896 mg/L 3compartmentss NA 95% Human Human -DTXSID0023298 Css NA 0.1172 mg/L PBTK NA 50% Human Human -DTXSID0023298 Css NA 0.7072 mg/L PBTK NA 95% Human Human -DTXSID0023298 Clint NA 21.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023298 Fup NA 0.2463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023298 Vd NA 2.532 L/kg 1compartment NA NA Rat Human +DTXSID0023298 TK.Half.Life NA 8.012 hours 1compartment NA NA Human Human +DTXSID0023298 Css NA 0.1988 mg/L 3compartmentss NA 50% Human Human +DTXSID0023298 Css NA 1.285 mg/L 3compartmentss NA 95% Human Human +DTXSID0023298 Css NA 0.1612 mg/L PBTK NA 50% Human Human +DTXSID0023298 Css NA 0.9788 mg/L PBTK NA 95% Human Human +DTXSID0023298 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023298 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023298 Vd NA 2.569 L/kg 1compartment NA NA Rat Human DTXSID0023298 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023298 TK.Half.Life NA 1.972 hours 1compartment NA NA Rat Human -DTXSID0023298 Css NA 0.07364 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023298 Css NA 0.3757 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023298 Css NA 0.06038 mg/L PBTK NA 50% Rat Human -DTXSID0023298 Css NA 0.2773 mg/L PBTK NA 95% Rat Human +DTXSID0023298 TK.Half.Life NA 2.275 hours 1compartment NA NA Rat Human +DTXSID0023298 Css NA 0.02473 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023298 Css NA 0.1291 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023298 Css NA 0.02014 mg/L PBTK NA 50% Rat Human +DTXSID0023298 Css NA 0.09935 mg/L PBTK NA 95% Rat Human DTXSID00233139 Clint 26.92 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID00233139 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID00233139 Vd NA 1.055 L/kg 1compartment NA NA Human Human -DTXSID00233139 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID00233139 TK.Half.Life NA 13.08 hours 1compartment NA NA Human Human -DTXSID00233139 Css NA 2.12 mg/L 3compartmentss NA 50% Human Human -DTXSID00233139 Css NA 20.4 mg/L 3compartmentss NA 95% Human Human -DTXSID00233139 Css NA 1.28 mg/L PBTK NA 50% Human Human -DTXSID00233139 Css NA 12 mg/L PBTK NA 95% Human Human +DTXSID00233139 Vd NA 0.6833 L/kg 1compartment NA NA Human Human +DTXSID00233139 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00233139 TK.Half.Life NA 8.837 hours 1compartment NA NA Human Human +DTXSID00233139 Css NA 2.209 mg/L 3compartmentss NA 50% Human Human +DTXSID00233139 Css NA 22.07 mg/L 3compartmentss NA 95% Human Human +DTXSID00233139 Css NA 1.317 mg/L PBTK NA 50% Human Human +DTXSID00233139 Css NA 13.03 mg/L PBTK NA 95% Human Human DTXSID00233139 Clint 26.92 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID00233139 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID00233139 Vd NA 0.7878 L/kg 1compartment NA NA Rat Human +DTXSID00233139 Vd NA 0.5206 L/kg 1compartment NA NA Rat Human DTXSID00233139 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID00233139 TK.Half.Life NA 5.786 hours 1compartment NA NA Rat Human -DTXSID00233139 Css NA 1.21 mg/L 3compartmentss NA 50% Rat Human -DTXSID00233139 Css NA 9.217 mg/L 3compartmentss NA 95% Rat Human -DTXSID00233139 Css NA 0.6868 mg/L PBTK NA 50% Rat Human -DTXSID00233139 Css NA 5.09 mg/L PBTK NA 95% Rat Human +DTXSID00233139 TK.Half.Life NA 4.284 hours 1compartment NA NA Rat Human +DTXSID00233139 Css NA 0.2931 mg/L 3compartmentss NA 50% Rat Human +DTXSID00233139 Css NA 2.436 mg/L 3compartmentss NA 95% Rat Human +DTXSID00233139 Css NA 0.169 mg/L PBTK NA 50% Rat Human +DTXSID00233139 Css NA 1.387 mg/L PBTK NA 95% Rat Human DTXSID0023321 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0023321 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0023321 Vd NA 2.506 L/kg 1compartment NA NA Human Human DTXSID0023321 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0023321 TK.Half.Life NA 7.932 hours 1compartment NA NA Human Human -DTXSID0023321 Css NA 0.2831 mg/L 3compartmentss NA 50% Human Human -DTXSID0023321 Css NA 1.779 mg/L 3compartmentss NA 95% Human Human -DTXSID0023321 Css NA 0.254 mg/L PBTK NA 50% Human Human -DTXSID0023321 Css NA 1.296 mg/L PBTK NA 95% Human Human +DTXSID0023321 Css NA 0.2758 mg/L 3compartmentss NA 50% Human Human +DTXSID0023321 Css NA 1.804 mg/L 3compartmentss NA 95% Human Human +DTXSID0023321 Css NA 0.2486 mg/L PBTK NA 50% Human Human +DTXSID0023321 Css NA 1.333 mg/L PBTK NA 95% Human Human DTXSID0023321 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0023321 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0023321 Vd NA 2.063 L/kg 1compartment NA NA Rat Human DTXSID0023321 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0023321 TK.Half.Life NA 2.443 hours 1compartment NA NA Rat Human -DTXSID0023321 Css NA 0.1322 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023321 Css NA 0.7112 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023321 Css NA 0.116 mg/L PBTK NA 50% Rat Human -DTXSID0023321 Css NA 0.4688 mg/L PBTK NA 95% Rat Human -DTXSID0023323 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0023321 Css NA 0.02922 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023321 Css NA 0.1575 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023321 Css NA 0.02665 mg/L PBTK NA 50% Rat Human +DTXSID0023321 Css NA 0.1082 mg/L PBTK NA 95% Rat Human +DTXSID0023323 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0023323 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0023323 Vd NA 1.561 L/kg 1compartment NA NA Human Human +DTXSID0023323 Vd NA 1.432 L/kg 1compartment NA NA Human Human DTXSID0023323 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023323 TK.Half.Life NA 10.1 hours 1compartment NA NA Human Human -DTXSID0023323 Css NA 0.7117 mg/L 3compartmentss NA 50% Human Human -DTXSID0023323 Css NA 5.293 mg/L 3compartmentss NA 95% Human Human -DTXSID0023323 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID0023323 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID0023323 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0023323 TK.Half.Life NA 9.268 hours 1compartment NA NA Human Human +DTXSID0023323 Css NA 0.395 mg/L 3compartmentss NA 50% Human Human +DTXSID0023323 Css NA 2.848 mg/L 3compartmentss NA 95% Human Human +DTXSID0023323 Css NA 0.3817 mg/L PBTK NA 50% Human Human +DTXSID0023323 Css NA 1.998 mg/L PBTK NA 95% Human Human +DTXSID0023323 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0023323 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0023323 Vd NA 1.614 L/kg 1compartment NA NA Rat Human +DTXSID0023323 Vd NA 1.494 L/kg 1compartment NA NA Rat Human DTXSID0023323 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023323 TK.Half.Life NA 3.558 hours 1compartment NA NA Rat Human -DTXSID0023323 Css NA 0.1753 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023323 Css NA 1.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023323 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0023323 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0023325 Clint NA 3.296 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0023323 TK.Half.Life NA 3.294 hours 1compartment NA NA Rat Human +DTXSID0023323 Css NA 0.001938 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023323 Css NA 0.01603 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023323 Css NA 0.001866 mg/L PBTK NA 50% Rat Human +DTXSID0023323 Css NA 0.01062 mg/L PBTK NA 95% Rat Human +DTXSID0023325 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID0023325 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0023325 Vd NA 1.022 L/kg 1compartment NA NA Human Human -DTXSID0023325 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023325 TK.Half.Life NA 7.386 hours 1compartment NA NA Human Human -DTXSID0023325 Css NA 0.9247 mg/L 3compartmentss NA 50% Human Human -DTXSID0023325 Css NA 5.914 mg/L 3compartmentss NA 95% Human Human -DTXSID0023325 Css NA 0.6464 mg/L PBTK NA 50% Human Human -DTXSID0023325 Css NA 3.729 mg/L PBTK NA 95% Human Human -DTXSID0023325 Clint NA 3.296 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0023325 Vd NA 2.438 L/kg 1compartment NA NA Human Human +DTXSID0023325 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0023325 TK.Half.Life NA 20.72 hours 1compartment NA NA Human Human +DTXSID0023325 Css NA 0.9544 mg/L 3compartmentss NA 50% Human Human +DTXSID0023325 Css NA 5.529 mg/L 3compartmentss NA 95% Human Human +DTXSID0023325 Css NA 0.7324 mg/L PBTK NA 50% Human Human +DTXSID0023325 Css NA 3.806 mg/L PBTK NA 95% Human Human +DTXSID0023325 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID0023325 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0023325 Vd NA 0.9822 L/kg 1compartment NA NA Rat Human -DTXSID0023325 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023325 TK.Half.Life NA 4.082 hours 1compartment NA NA Rat Human -DTXSID0023325 Css NA 0.4522 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023325 Css NA 2.191 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023325 Css NA 0.3011 mg/L PBTK NA 50% Rat Human -DTXSID0023325 Css NA 1.271 mg/L PBTK NA 95% Rat Human -DTXSID0023329 Clint NA 29.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023329 Fup NA 0.2661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023329 Vd NA 1.609 L/kg 1compartment NA NA Human Human +DTXSID0023325 Vd NA 2.056 L/kg 1compartment NA NA Rat Human +DTXSID0023325 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0023325 TK.Half.Life NA 7.58 hours 1compartment NA NA Rat Human +DTXSID0023325 Css NA 0.1102 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023325 Css NA 0.4874 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023325 Css NA 0.08499 mg/L PBTK NA 50% Rat Human +DTXSID0023325 Css NA 0.3208 mg/L PBTK NA 95% Rat Human +DTXSID0023329 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023329 Fup 0.0674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023329 Vd NA 0.8087 L/kg 1compartment NA NA Human Human DTXSID0023329 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023329 TK.Half.Life NA 2.136 hours 1compartment NA NA Human Human -DTXSID0023329 Css NA 0.07366 mg/L 3compartmentss NA 50% Human Human -DTXSID0023329 Css NA 0.5186 mg/L 3compartmentss NA 95% Human Human -DTXSID0023329 Css NA 0.05433 mg/L PBTK NA 50% Human Human -DTXSID0023329 Css NA 0.3562 mg/L PBTK NA 95% Human Human -DTXSID0023329 Clint NA 29.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023329 Fup NA 0.2661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023329 Vd NA 1.273 L/kg 1compartment NA NA Rat Human +DTXSID0023329 TK.Half.Life NA 2.776 hours 1compartment NA NA Human Human +DTXSID0023329 Css NA 0.4337 mg/L 3compartmentss NA 50% Human Human +DTXSID0023329 Css NA 3.235 mg/L 3compartmentss NA 95% Human Human +DTXSID0023329 Css NA 0.2706 mg/L PBTK NA 50% Human Human +DTXSID0023329 Css NA 1.937 mg/L PBTK NA 95% Human Human +DTXSID0023329 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023329 Fup 0.0674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023329 Vd NA 0.6327 L/kg 1compartment NA NA Rat Human DTXSID0023329 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023329 TK.Half.Life NA 0.8029 hours 1compartment NA NA Rat Human -DTXSID0023329 Css NA 0.03987 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023329 Css NA 0.2136 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023329 Css NA 0.02836 mg/L PBTK NA 50% Rat Human -DTXSID0023329 Css NA 0.1416 mg/L PBTK NA 95% Rat Human +DTXSID0023329 TK.Half.Life NA 1.267 hours 1compartment NA NA Rat Human +DTXSID0023329 Css NA 0.05605 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023329 Css NA 0.3314 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023329 Css NA 0.034 mg/L PBTK NA 50% Rat Human +DTXSID0023329 Css NA 0.1957 mg/L PBTK NA 95% Rat Human DTXSID0023371 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0023371 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0023371 Vd NA 0.4771 L/kg 1compartment NA NA Human Human -DTXSID0023371 Days.Css NA 285 Days PBTK NA NA Human Human -DTXSID0023371 TK.Half.Life NA 1070 hours 1compartment NA NA Human Human -DTXSID0023371 Css NA 387.5 mg/L 3compartmentss NA 50% Human Human -DTXSID0023371 Css NA 1849 mg/L 3compartmentss NA 95% Human Human -DTXSID0023371 Css NA 227 mg/L PBTK NA 50% Human Human -DTXSID0023371 Css NA 1054 mg/L PBTK NA 95% Human Human +DTXSID0023371 Vd NA 0.3106 L/kg 1compartment NA NA Human Human +DTXSID0023371 Days.Css NA 178 Days PBTK NA NA Human Human +DTXSID0023371 TK.Half.Life NA 677.6 hours 1compartment NA NA Human Human +DTXSID0023371 Css NA 373.4 mg/L 3compartmentss NA 50% Human Human +DTXSID0023371 Css NA 1732 mg/L 3compartmentss NA 95% Human Human +DTXSID0023371 Css NA 217.8 mg/L PBTK NA 50% Human Human +DTXSID0023371 Css NA 1004 mg/L PBTK NA 95% Human Human DTXSID0023371 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID0023371 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0023371 Vd NA 0.36 L/kg 1compartment NA NA Rat Human -DTXSID0023371 Days.Css NA 68 Days PBTK NA NA Rat Human -DTXSID0023371 TK.Half.Life NA 267.1 hours 1compartment NA NA Rat Human -DTXSID0023371 Css NA 112.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023371 Css NA 431.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023371 Css NA 61.33 mg/L PBTK NA 50% Rat Human -DTXSID0023371 Css NA 233.9 mg/L PBTK NA 95% Rat Human +DTXSID0023371 Vd NA 0.2537 L/kg 1compartment NA NA Rat Human +DTXSID0023371 Days.Css NA 44 Days PBTK NA NA Rat Human +DTXSID0023371 TK.Half.Life NA 186.9 hours 1compartment NA NA Rat Human +DTXSID0023371 Css NA 24.76 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023371 Css NA 92.98 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023371 Css NA 13.94 mg/L PBTK NA 50% Rat Human +DTXSID0023371 Css NA 52.1 mg/L PBTK NA 95% Rat Human DTXSID0023373 Clint 12.07 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0023373 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0023373 Vd NA 0.8037 L/kg 1compartment NA NA Human Human DTXSID0023373 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID0023373 TK.Half.Life NA 11.86 hours 1compartment NA NA Human Human -DTXSID0023373 Css NA 2.285 mg/L 3compartmentss NA 50% Human Human -DTXSID0023373 Css NA 22.21 mg/L 3compartmentss NA 95% Human Human -DTXSID0023373 Css NA 1.57 mg/L PBTK NA 50% Human Human -DTXSID0023373 Css NA 13.72 mg/L PBTK NA 95% Human Human +DTXSID0023373 Css NA 2.176 mg/L 3compartmentss NA 50% Human Human +DTXSID0023373 Css NA 18.68 mg/L 3compartmentss NA 95% Human Human +DTXSID0023373 Css NA 1.523 mg/L PBTK NA 50% Human Human +DTXSID0023373 Css NA 13.07 mg/L PBTK NA 95% Human Human DTXSID0023373 Clint 12.07 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID0023373 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0023373 Vd NA 0.8602 L/kg 1compartment NA NA Rat Human DTXSID0023373 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0023373 TK.Half.Life NA 3.981 hours 1compartment NA NA Rat Human -DTXSID0023373 Css NA 0.706 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023373 Css NA 4.789 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023373 Css NA 0.4461 mg/L PBTK NA 50% Rat Human -DTXSID0023373 Css NA 2.779 mg/L PBTK NA 95% Rat Human -DTXSID0023377 Clint NA 15.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0023373 Css NA 0.1419 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023373 Css NA 0.9056 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023373 Css NA 0.1028 mg/L PBTK NA 50% Rat Human +DTXSID0023373 Css NA 0.6563 mg/L PBTK NA 95% Rat Human +DTXSID0023377 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0023377 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0023377 Vd NA 2.773 L/kg 1compartment NA NA Human Human +DTXSID0023377 Vd NA 2.763 L/kg 1compartment NA NA Human Human DTXSID0023377 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023377 TK.Half.Life NA 6.576 hours 1compartment NA NA Human Human -DTXSID0023377 Css NA 0.1936 mg/L 3compartmentss NA 50% Human Human -DTXSID0023377 Css NA 1.197 mg/L 3compartmentss NA 95% Human Human -DTXSID0023377 Css NA 0.1508 mg/L PBTK NA 50% Human Human -DTXSID0023377 Css NA 0.8793 mg/L PBTK NA 95% Human Human -DTXSID0023377 Clint NA 15.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0023377 TK.Half.Life NA 5.188 hours 1compartment NA NA Human Human +DTXSID0023377 Css NA 0.1315 mg/L 3compartmentss NA 50% Human Human +DTXSID0023377 Css NA 0.8618 mg/L 3compartmentss NA 95% Human Human +DTXSID0023377 Css NA 0.1023 mg/L PBTK NA 50% Human Human +DTXSID0023377 Css NA 0.6348 mg/L PBTK NA 95% Human Human +DTXSID0023377 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0023377 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0023377 Vd NA 2.165 L/kg 1compartment NA NA Rat Human +DTXSID0023377 Vd NA 2.158 L/kg 1compartment NA NA Rat Human DTXSID0023377 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023377 TK.Half.Life NA 1.736 hours 1compartment NA NA Rat Human -DTXSID0023377 Css NA 0.1043 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023377 Css NA 0.4832 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023377 Css NA 0.07868 mg/L PBTK NA 50% Rat Human -DTXSID0023377 Css NA 0.3415 mg/L PBTK NA 95% Rat Human -DTXSID0023458 Clint NA 28.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023458 Fup NA 0.0303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023458 Vd NA 1.795 L/kg 1compartment NA NA Human Human +DTXSID0023377 TK.Half.Life NA 1.423 hours 1compartment NA NA Rat Human +DTXSID0023377 Css NA 0.01636 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023377 Css NA 0.08266 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023377 Css NA 0.01285 mg/L PBTK NA 50% Rat Human +DTXSID0023377 Css NA 0.06082 mg/L PBTK NA 95% Rat Human +DTXSID0023406 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023406 Fup 0.0034 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0023406 Vd NA 0.5591 L/kg 1compartment NA NA Human Human +DTXSID0023406 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0023406 TK.Half.Life NA 11.15 hours 1compartment NA NA Human Human +DTXSID0023406 Css NA 3.5 mg/L 3compartmentss NA 50% Human Human +DTXSID0023406 Css NA 30.22 mg/L 3compartmentss NA 95% Human Human +DTXSID0023406 Css NA 2.096 mg/L PBTK NA 50% Human Human +DTXSID0023406 Css NA 17.69 mg/L PBTK NA 95% Human Human +DTXSID0023406 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023406 Fup 0.0034 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0023406 Vd NA 0.4875 L/kg 1compartment NA NA Rat Human +DTXSID0023406 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0023406 TK.Half.Life NA 6.533 hours 1compartment NA NA Rat Human +DTXSID0023406 Css NA 0.4828 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023406 Css NA 3.347 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023406 Css NA 0.2784 mg/L PBTK NA 50% Rat Human +DTXSID0023406 Css NA 1.902 mg/L PBTK NA 95% Rat Human +DTXSID00234343 Clint 4.04 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00234343 Fup 0.02 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00234343 Vd NA 2.202 L/kg 1compartment NA NA Human Human +DTXSID00234343 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID00234343 TK.Half.Life NA 114.2 hours 1compartment NA NA Human Human +DTXSID00234343 Css NA 7.913 mg/L 3compartmentss NA 50% Human Human +DTXSID00234343 Css NA 53.55 mg/L 3compartmentss NA 95% Human Human +DTXSID00234343 Css NA 5.162 mg/L PBTK NA 50% Human Human +DTXSID00234343 Css NA 32.63 mg/L PBTK NA 95% Human Human +DTXSID00234343 Clint 4.04 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00234343 Fup 0.02 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00234343 Vd NA 1.637 L/kg 1compartment NA NA Rat Human +DTXSID00234343 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID00234343 TK.Half.Life NA 31.31 hours 1compartment NA NA Rat Human +DTXSID00234343 Css NA 0.9579 mg/L 3compartmentss NA 50% Rat Human +DTXSID00234343 Css NA 4.966 mg/L 3compartmentss NA 95% Rat Human +DTXSID00234343 Css NA 0.6095 mg/L PBTK NA 50% Rat Human +DTXSID00234343 Css NA 2.981 mg/L PBTK NA 95% Rat Human +DTXSID0023458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023458 Fup 0.0854 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023458 Vd NA 3.226 L/kg 1compartment NA NA Human Human DTXSID0023458 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023458 TK.Half.Life NA 7.208 hours 1compartment NA NA Human Human -DTXSID0023458 Css NA 0.5234 mg/L 3compartmentss NA 50% Human Human -DTXSID0023458 Css NA 4.96 mg/L 3compartmentss NA 95% Human Human -DTXSID0023458 Css NA 0.3522 mg/L PBTK NA 50% Human Human -DTXSID0023458 Css NA 3.119 mg/L PBTK NA 95% Human Human -DTXSID0023458 Clint NA 28.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023458 Fup NA 0.0303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023458 Vd NA 1.497 L/kg 1compartment NA NA Rat Human +DTXSID0023458 TK.Half.Life NA 14.71 hours 1compartment NA NA Human Human +DTXSID0023458 Css NA 0.4546 mg/L 3compartmentss NA 50% Human Human +DTXSID0023458 Css NA 3.079 mg/L 3compartmentss NA 95% Human Human +DTXSID0023458 Css NA 0.3372 mg/L PBTK NA 50% Human Human +DTXSID0023458 Css NA 2.165 mg/L PBTK NA 95% Human Human +DTXSID0023458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023458 Fup 0.0854 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023458 Vd NA 2.533 L/kg 1compartment NA NA Rat Human DTXSID0023458 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023458 TK.Half.Life NA 3.228 hours 1compartment NA NA Rat Human -DTXSID0023458 Css NA 0.298 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023458 Css NA 2.284 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023458 Css NA 0.1891 mg/L PBTK NA 50% Rat Human -DTXSID0023458 Css NA 1.324 mg/L PBTK NA 95% Rat Human -DTXSID0023533 Clint NA 19.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023533 Fup NA 0.9917 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023533 Vd NA 0.6994 L/kg 1compartment NA NA Human Human +DTXSID0023458 TK.Half.Life NA 3.043 hours 1compartment NA NA Rat Human +DTXSID0023458 Css NA 0.05808 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023458 Css NA 0.3495 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023458 Css NA 0.04288 mg/L PBTK NA 50% Rat Human +DTXSID0023458 Css NA 0.25 mg/L PBTK NA 95% Rat Human +DTXSID0023533 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023533 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023533 Vd NA 0.5325 L/kg 1compartment NA NA Human Human DTXSID0023533 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023533 TK.Half.Life NA 0.5112 hours 1compartment NA NA Human Human -DTXSID0023533 Css NA 0.02574 mg/L 3compartmentss NA 50% Human Human -DTXSID0023533 Css NA 0.3841 mg/L 3compartmentss NA 95% Human Human -DTXSID0023533 Css NA 0.02094 mg/L PBTK NA 50% Human Human -DTXSID0023533 Css NA 0.2769 mg/L PBTK NA 95% Human Human -DTXSID0023533 Clint NA 19.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023533 Fup NA 0.9917 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023533 Vd NA 0.7493 L/kg 1compartment NA NA Rat Human +DTXSID0023533 TK.Half.Life NA 5.567 hours 1compartment NA NA Human Human +DTXSID0023533 Css NA 0.5935 mg/L 3compartmentss NA 50% Human Human +DTXSID0023533 Css NA 4.111 mg/L 3compartmentss NA 95% Human Human +DTXSID0023533 Css NA 0.4564 mg/L PBTK NA 50% Human Human +DTXSID0023533 Css NA 2.577 mg/L PBTK NA 95% Human Human +DTXSID0023533 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023533 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023533 Vd NA 0.569 L/kg 1compartment NA NA Rat Human DTXSID0023533 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023533 TK.Half.Life NA 0.2609 hours 1compartment NA NA Rat Human -DTXSID0023533 Css NA 0.01276 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023533 Css NA 0.1444 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023533 Css NA 0.0103 mg/L PBTK NA 50% Rat Human -DTXSID0023533 Css NA 0.1004 mg/L PBTK NA 95% Rat Human +DTXSID0023533 TK.Half.Life NA 2.027 hours 1compartment NA NA Rat Human +DTXSID0023533 Css NA 0.002874 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023533 Css NA 0.01939 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023533 Css NA 0.002124 mg/L PBTK NA 50% Rat Human +DTXSID0023533 Css NA 0.01148 mg/L PBTK NA 95% Rat Human DTXSID0023581 Clint 24.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0023581 Fup 0.00398 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0023581 Vd NA 1.074 L/kg 1compartment NA NA Human Human DTXSID0023581 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID0023581 TK.Half.Life NA 12.16 hours 1compartment NA NA Human Human -DTXSID0023581 Css NA 1.922 mg/L 3compartmentss NA 50% Human Human -DTXSID0023581 Css NA 14.63 mg/L 3compartmentss NA 95% Human Human -DTXSID0023581 Css NA 1.17 mg/L PBTK NA 50% Human Human -DTXSID0023581 Css NA 8.736 mg/L PBTK NA 95% Human Human +DTXSID0023581 Css NA 1.832 mg/L 3compartmentss NA 50% Human Human +DTXSID0023581 Css NA 14.21 mg/L 3compartmentss NA 95% Human Human +DTXSID0023581 Css NA 1.125 mg/L PBTK NA 50% Human Human +DTXSID0023581 Css NA 8.565 mg/L PBTK NA 95% Human Human DTXSID0023581 Clint 24.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0023581 Fup 0.00398 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0023581 Vd NA 0.8531 L/kg 1compartment NA NA Rat Human DTXSID0023581 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0023581 TK.Half.Life NA 5.929 hours 1compartment NA NA Rat Human -DTXSID0023581 Css NA 1.103 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023581 Css NA 7.076 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023581 Css NA 0.632 mg/L PBTK NA 50% Rat Human -DTXSID0023581 Css NA 3.972 mg/L PBTK NA 95% Rat Human -DTXSID0023587 Clint NA 1.476 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023587 Fup NA 0.3718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023587 Vd NA 0.685 L/kg 1compartment NA NA Human Human -DTXSID0023587 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023587 TK.Half.Life NA 3.745 hours 1compartment NA NA Human Human -DTXSID0023587 Css NA 0.5843 mg/L 3compartmentss NA 50% Human Human -DTXSID0023587 Css NA 2.826 mg/L 3compartmentss NA 95% Human Human -DTXSID0023587 Css NA 0.433 mg/L PBTK NA 50% Human Human -DTXSID0023587 Css NA 1.848 mg/L PBTK NA 95% Human Human -DTXSID0023587 Clint NA 1.476 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023587 Fup NA 0.3718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023587 Vd NA 0.6521 L/kg 1compartment NA NA Rat Human +DTXSID0023581 Css NA 0.2486 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023581 Css NA 1.615 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023581 Css NA 0.1469 mg/L PBTK NA 50% Rat Human +DTXSID0023581 Css NA 0.945 mg/L PBTK NA 95% Rat Human +DTXSID0023583 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023583 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0023583 Vd NA 0.2629 L/kg 1compartment NA NA Human Human +DTXSID0023583 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0023583 TK.Half.Life NA 11.34 hours 1compartment NA NA Human Human +DTXSID0023583 Css NA 5.42 mg/L 3compartmentss NA 50% Human Human +DTXSID0023583 Css NA 23.65 mg/L 3compartmentss NA 95% Human Human +DTXSID0023583 Css NA 3.37 mg/L PBTK NA 50% Human Human +DTXSID0023583 Css NA 13.95 mg/L PBTK NA 95% Human Human +DTXSID0023583 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023583 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0023583 Vd NA 0.2731 L/kg 1compartment NA NA Rat Human +DTXSID0023583 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0023583 TK.Half.Life NA 4.014 hours 1compartment NA NA Rat Human +DTXSID0023583 Css NA 0.1326 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023583 Css NA 0.8246 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023583 Css NA 0.0794 mg/L PBTK NA 50% Rat Human +DTXSID0023583 Css NA 0.4752 mg/L PBTK NA 95% Rat Human +DTXSID0023587 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023587 Fup 0.509 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023587 Vd NA 0.8643 L/kg 1compartment NA NA Human Human +DTXSID0023587 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0023587 TK.Half.Life NA 11.32 hours 1compartment NA NA Human Human +DTXSID0023587 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human +DTXSID0023587 Css NA 7.406 mg/L 3compartmentss NA 95% Human Human +DTXSID0023587 Css NA 1.104 mg/L PBTK NA 50% Human Human +DTXSID0023587 Css NA 4.809 mg/L PBTK NA 95% Human Human +DTXSID0023587 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023587 Fup 0.509 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023587 Vd NA 0.811 L/kg 1compartment NA NA Rat Human DTXSID0023587 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023587 TK.Half.Life NA 1.828 hours 1compartment NA NA Rat Human -DTXSID0023587 Css NA 0.2456 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023587 Css NA 1.001 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023587 Css NA 0.1753 mg/L PBTK NA 50% Rat Human -DTXSID0023587 Css NA 0.5988 mg/L PBTK NA 95% Rat Human -DTXSID0023589 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0023587 TK.Half.Life NA 3.538 hours 1compartment NA NA Rat Human +DTXSID0023587 Css NA 0.08477 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023587 Css NA 0.4309 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023587 Css NA 0.06761 mg/L PBTK NA 50% Rat Human +DTXSID0023587 Css NA 0.2671 mg/L PBTK NA 95% Rat Human +DTXSID0023589 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0023589 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0023589 Vd NA 1.982 L/kg 1compartment NA NA Human Human -DTXSID0023589 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0023589 TK.Half.Life NA 20.71 hours 1compartment NA NA Human Human -DTXSID0023589 Css NA 0.9677 mg/L 3compartmentss NA 50% Human Human -DTXSID0023589 Css NA 7.244 mg/L 3compartmentss NA 95% Human Human -DTXSID0023589 Css NA 0.9588 mg/L PBTK NA 50% Human Human -DTXSID0023589 Css NA 4.916 mg/L PBTK NA 95% Human Human -DTXSID0023589 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0023589 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0023589 TK.Half.Life NA 2.674 hours 1compartment NA NA Human Human +DTXSID0023589 Css NA 0.07073 mg/L 3compartmentss NA 50% Human Human +DTXSID0023589 Css NA 0.7383 mg/L 3compartmentss NA 95% Human Human +DTXSID0023589 Css NA 0.06846 mg/L PBTK NA 50% Human Human +DTXSID0023589 Css NA 0.5374 mg/L PBTK NA 95% Human Human +DTXSID0023589 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0023589 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0023589 Vd NA 2.008 L/kg 1compartment NA NA Rat Human DTXSID0023589 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023589 TK.Half.Life NA 7.141 hours 1compartment NA NA Rat Human -DTXSID0023589 Css NA 0.2499 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023589 Css NA 1.829 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023589 Css NA 0.2427 mg/L PBTK NA 50% Rat Human -DTXSID0023589 Css NA 1.153 mg/L PBTK NA 95% Rat Human -DTXSID0023612 Clint NA 7.793 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023612 Fup NA 0.1337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023612 Vd NA 0.2451 L/kg 1compartment NA NA Human Human +DTXSID0023589 TK.Half.Life NA 1.498 hours 1compartment NA NA Rat Human +DTXSID0023589 Css NA 0.001618 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023589 Css NA 0.02149 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023589 Css NA 0.001563 mg/L PBTK NA 50% Rat Human +DTXSID0023589 Css NA 0.01534 mg/L PBTK NA 95% Rat Human +DTXSID00235971 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00235971 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00235971 Vd NA 3.155 L/kg 1compartment NA NA Human Human +DTXSID00235971 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID00235971 TK.Half.Life NA 50.34 hours 1compartment NA NA Human Human +DTXSID00235971 Css NA 1.816 mg/L 3compartmentss NA 50% Human Human +DTXSID00235971 Css NA 11.87 mg/L 3compartmentss NA 95% Human Human +DTXSID00235971 Css NA 1.28 mg/L PBTK NA 50% Human Human +DTXSID00235971 Css NA 8.041 mg/L PBTK NA 95% Human Human +DTXSID00235971 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00235971 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00235971 Vd NA 2.386 L/kg 1compartment NA NA Rat Human +DTXSID00235971 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID00235971 TK.Half.Life NA 7.276 hours 1compartment NA NA Rat Human +DTXSID00235971 Css NA 0.2342 mg/L 3compartmentss NA 50% Rat Human +DTXSID00235971 Css NA 1.322 mg/L 3compartmentss NA 95% Rat Human +DTXSID00235971 Css NA 0.164 mg/L PBTK NA 50% Rat Human +DTXSID00235971 Css NA 0.904 mg/L PBTK NA 95% Rat Human +DTXSID0023612 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023612 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023612 Vd NA 0.2991 L/kg 1compartment NA NA Human Human DTXSID0023612 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023612 TK.Half.Life NA 1.047 hours 1compartment NA NA Human Human -DTXSID0023612 Css NA 0.581 mg/L 3compartmentss NA 50% Human Human -DTXSID0023612 Css NA 3.93 mg/L 3compartmentss NA 95% Human Human -DTXSID0023612 Css NA 0.3562 mg/L PBTK NA 50% Human Human -DTXSID0023612 Css NA 2.341 mg/L PBTK NA 95% Human Human -DTXSID0023612 Clint NA 7.793 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023612 Fup NA 0.1337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023612 Vd NA 0.2468 L/kg 1compartment NA NA Rat Human +DTXSID0023612 TK.Half.Life NA 0.9381 hours 1compartment NA NA Human Human +DTXSID0023612 Css NA 0.31 mg/L 3compartmentss NA 50% Human Human +DTXSID0023612 Css NA 1.823 mg/L 3compartmentss NA 95% Human Human +DTXSID0023612 Css NA 0.1994 mg/L PBTK NA 50% Human Human +DTXSID0023612 Css NA 1.116 mg/L PBTK NA 95% Human Human +DTXSID0023612 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023612 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023612 Vd NA 0.3031 L/kg 1compartment NA NA Rat Human DTXSID0023612 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023612 TK.Half.Life NA 0.6342 hours 1compartment NA NA Rat Human -DTXSID0023612 Css NA 0.3108 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023612 Css NA 1.556 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023612 Css NA 0.1782 mg/L PBTK NA 50% Rat Human -DTXSID0023612 Css NA 0.8624 mg/L PBTK NA 95% Rat Human -DTXSID0023616 Clint NA 11.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023616 Fup NA 0.1194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023616 Vd NA 0.2441 L/kg 1compartment NA NA Human Human +DTXSID0023612 TK.Half.Life NA 0.5497 hours 1compartment NA NA Rat Human +DTXSID0023612 Css NA 0.0374 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023612 Css NA 0.1574 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023612 Css NA 0.02348 mg/L PBTK NA 50% Rat Human +DTXSID0023612 Css NA 0.09392 mg/L PBTK NA 95% Rat Human +DTXSID0023616 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023616 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023616 Vd NA 0.2795 L/kg 1compartment NA NA Human Human DTXSID0023616 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023616 TK.Half.Life NA 0.8785 hours 1compartment NA NA Human Human -DTXSID0023616 Css NA 0.4726 mg/L 3compartmentss NA 50% Human Human -DTXSID0023616 Css NA 3.501 mg/L 3compartmentss NA 95% Human Human -DTXSID0023616 Css NA 0.2884 mg/L PBTK NA 50% Human Human -DTXSID0023616 Css NA 2.073 mg/L PBTK NA 95% Human Human -DTXSID0023616 Clint NA 11.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023616 Fup NA 0.1194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023616 Vd NA 0.2438 L/kg 1compartment NA NA Rat Human +DTXSID0023616 TK.Half.Life NA 1.098 hours 1compartment NA NA Human Human +DTXSID0023616 Css NA 0.4255 mg/L 3compartmentss NA 50% Human Human +DTXSID0023616 Css NA 2.455 mg/L 3compartmentss NA 95% Human Human +DTXSID0023616 Css NA 0.268 mg/L PBTK NA 50% Human Human +DTXSID0023616 Css NA 1.499 mg/L PBTK NA 95% Human Human +DTXSID0023616 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023616 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023616 Vd NA 0.28 L/kg 1compartment NA NA Rat Human DTXSID0023616 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023616 TK.Half.Life NA 0.5291 hours 1compartment NA NA Rat Human -DTXSID0023616 Css NA 0.2587 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023616 Css NA 1.406 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023616 Css NA 0.1477 mg/L PBTK NA 50% Rat Human -DTXSID0023616 Css NA 0.7804 mg/L PBTK NA 95% Rat Human -DTXSID0023618 Clint NA 1.206 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0023616 TK.Half.Life NA 0.6484 hours 1compartment NA NA Rat Human +DTXSID0023616 Css NA 0.05122 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023616 Css NA 0.2122 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023616 Css NA 0.03154 mg/L PBTK NA 50% Rat Human +DTXSID0023616 Css NA 0.1248 mg/L PBTK NA 95% Rat Human +DTXSID0023618 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0023618 Fup 0.017 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0023618 Vd NA 0.3865 L/kg 1compartment NA NA Human Human -DTXSID0023618 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID0023618 TK.Half.Life NA 47.22 hours 1compartment NA NA Human Human -DTXSID0023618 Css NA 21.42 mg/L 3compartmentss NA 50% Human Human -DTXSID0023618 Css NA 150.4 mg/L 3compartmentss NA 95% Human Human -DTXSID0023618 Css NA 12.72 mg/L PBTK NA 50% Human Human -DTXSID0023618 Css NA 87.16 mg/L PBTK NA 95% Human Human -DTXSID0023618 Clint NA 1.206 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0023618 Vd NA 0.3897 L/kg 1compartment NA NA Human Human +DTXSID0023618 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0023618 TK.Half.Life NA 4.097 hours 1compartment NA NA Human Human +DTXSID0023618 Css NA 1.802 mg/L 3compartmentss NA 50% Human Human +DTXSID0023618 Css NA 17.9 mg/L 3compartmentss NA 95% Human Human +DTXSID0023618 Css NA 1.058 mg/L PBTK NA 50% Human Human +DTXSID0023618 Css NA 10.41 mg/L PBTK NA 95% Human Human +DTXSID0023618 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0023618 Fup 0.017 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0023618 Vd NA 0.3115 L/kg 1compartment NA NA Rat Human -DTXSID0023618 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0023618 TK.Half.Life NA 19.7 hours 1compartment NA NA Rat Human -DTXSID0023618 Css NA 9.466 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023618 Css NA 54.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023618 Css NA 5.222 mg/L PBTK NA 50% Rat Human -DTXSID0023618 Css NA 29.5 mg/L PBTK NA 95% Rat Human -DTXSID0023660 Clint NA 18.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023660 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023660 Vd NA 2.735 L/kg 1compartment NA NA Human Human +DTXSID0023618 Vd NA 0.3138 L/kg 1compartment NA NA Rat Human +DTXSID0023618 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0023618 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human +DTXSID0023618 Css NA 0.2334 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023618 Css NA 1.865 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023618 Css NA 0.1336 mg/L PBTK NA 50% Rat Human +DTXSID0023618 Css NA 1.058 mg/L PBTK NA 95% Rat Human +DTXSID0023660 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023660 Fup 0.0655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023660 Vd NA 2.571 L/kg 1compartment NA NA Human Human DTXSID0023660 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0023660 TK.Half.Life NA 18.33 hours 1compartment NA NA Human Human -DTXSID0023660 Css NA 0.8044 mg/L 3compartmentss NA 50% Human Human -DTXSID0023660 Css NA 5.073 mg/L 3compartmentss NA 95% Human Human -DTXSID0023660 Css NA 0.5552 mg/L PBTK NA 50% Human Human -DTXSID0023660 Css NA 3.39 mg/L PBTK NA 95% Human Human -DTXSID0023660 Clint NA 18.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023660 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023660 Vd NA 2.058 L/kg 1compartment NA NA Rat Human +DTXSID0023660 TK.Half.Life NA 16.2 hours 1compartment NA NA Human Human +DTXSID0023660 Css NA 0.7364 mg/L 3compartmentss NA 50% Human Human +DTXSID0023660 Css NA 4.718 mg/L 3compartmentss NA 95% Human Human +DTXSID0023660 Css NA 0.5009 mg/L PBTK NA 50% Human Human +DTXSID0023660 Css NA 3.092 mg/L PBTK NA 95% Human Human +DTXSID0023660 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023660 Fup 0.0655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023660 Vd NA 1.931 L/kg 1compartment NA NA Rat Human DTXSID0023660 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023660 TK.Half.Life NA 4.018 hours 1compartment NA NA Rat Human -DTXSID0023660 Css NA 0.4396 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023660 Css NA 2.167 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023660 Css NA 0.29 mg/L PBTK NA 50% Rat Human -DTXSID0023660 Css NA 1.403 mg/L PBTK NA 95% Rat Human -DTXSID0023743 Clint NA 0.159 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023743 Fup NA 0.9529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023743 Vd NA 0.8078 L/kg 1compartment NA NA Human Human +DTXSID0023660 TK.Half.Life NA 3.97 hours 1compartment NA NA Rat Human +DTXSID0023660 Css NA 0.09457 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023660 Css NA 0.4999 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023660 Css NA 0.06357 mg/L PBTK NA 50% Rat Human +DTXSID0023660 Css NA 0.3292 mg/L PBTK NA 95% Rat Human +DTXSID0023668 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023668 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0023668 Vd NA 0.4834 L/kg 1compartment NA NA Human Human +DTXSID0023668 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0023668 TK.Half.Life NA 5.686 hours 1compartment NA NA Human Human +DTXSID0023668 Css NA 0.746 mg/L 3compartmentss NA 50% Human Human +DTXSID0023668 Css NA 4.942 mg/L 3compartmentss NA 95% Human Human +DTXSID0023668 Css NA 0.5632 mg/L PBTK NA 50% Human Human +DTXSID0023668 Css NA 3.022 mg/L PBTK NA 95% Human Human +DTXSID0023668 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023668 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0023668 Vd NA 0.4925 L/kg 1compartment NA NA Rat Human +DTXSID0023668 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0023668 TK.Half.Life NA 1.974 hours 1compartment NA NA Rat Human +DTXSID0023668 Css NA 0.003986 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023668 Css NA 0.02633 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023668 Css NA 0.002876 mg/L PBTK NA 50% Rat Human +DTXSID0023668 Css NA 0.01565 mg/L PBTK NA 95% Rat Human +DTXSID0023743 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023743 Fup 0.671 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023743 Vd NA 0.6881 L/kg 1compartment NA NA Human Human DTXSID0023743 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023743 TK.Half.Life NA 4.37 hours 1compartment NA NA Human Human -DTXSID0023743 Css NA 0.6574 mg/L 3compartmentss NA 50% Human Human -DTXSID0023743 Css NA 2.313 mg/L 3compartmentss NA 95% Human Human -DTXSID0023743 Css NA 0.5529 mg/L PBTK NA 50% Human Human -DTXSID0023743 Css NA 1.637 mg/L PBTK NA 95% Human Human -DTXSID0023743 Clint NA 0.159 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023743 Fup NA 0.9529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023743 Vd NA 0.8375 L/kg 1compartment NA NA Rat Human +DTXSID0023743 TK.Half.Life NA 6.652 hours 1compartment NA NA Human Human +DTXSID0023743 Css NA 0.9651 mg/L 3compartmentss NA 50% Human Human +DTXSID0023743 Css NA 6.294 mg/L 3compartmentss NA 95% Human Human +DTXSID0023743 Css NA 0.778 mg/L PBTK NA 50% Human Human +DTXSID0023743 Css NA 3.968 mg/L PBTK NA 95% Human Human +DTXSID0023743 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023743 Fup 0.671 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023743 Vd NA 0.7057 L/kg 1compartment NA NA Rat Human DTXSID0023743 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023743 TK.Half.Life NA 1.722 hours 1compartment NA NA Rat Human -DTXSID0023743 Css NA 0.188 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023743 Css NA 0.6153 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023743 Css NA 0.1565 mg/L PBTK NA 50% Rat Human -DTXSID0023743 Css NA 0.4016 mg/L PBTK NA 95% Rat Human +DTXSID0023743 TK.Half.Life NA 2.319 hours 1compartment NA NA Rat Human +DTXSID0023743 Css NA 0.02565 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023743 Css NA 0.1907 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023743 Css NA 0.01986 mg/L PBTK NA 50% Rat Human +DTXSID0023743 Css NA 0.12 mg/L PBTK NA 95% Rat Human DTXSID0023745 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0023745 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023745 Vd NA 0.7054 L/kg 1compartment NA NA Human Human +DTXSID0023745 Vd NA 0.567 L/kg 1compartment NA NA Human Human DTXSID0023745 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023745 TK.Half.Life NA 4.566 hours 1compartment NA NA Human Human -DTXSID0023745 Css NA 0.8452 mg/L 3compartmentss NA 50% Human Human -DTXSID0023745 Css NA 5.573 mg/L 3compartmentss NA 95% Human Human -DTXSID0023745 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID0023745 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID0023745 TK.Half.Life NA 3.669 hours 1compartment NA NA Human Human +DTXSID0023745 Css NA 0.76 mg/L 3compartmentss NA 50% Human Human +DTXSID0023745 Css NA 5.195 mg/L 3compartmentss NA 95% Human Human +DTXSID0023745 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID0023745 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID0023745 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0023745 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023745 Vd NA 0.7545 L/kg 1compartment NA NA Rat Human +DTXSID0023745 Vd NA 0.6088 L/kg 1compartment NA NA Rat Human DTXSID0023745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023745 TK.Half.Life NA 1.663 hours 1compartment NA NA Rat Human -DTXSID0023745 Css NA 0.2123 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023745 Css NA 1.338 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023745 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0023745 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0023747 Clint NA 7.758 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0023745 TK.Half.Life NA 1.342 hours 1compartment NA NA Rat Human +DTXSID0023745 Css NA 0.01399 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023745 Css NA 0.103 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023745 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID0023745 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID0023747 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0023747 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0023747 Vd NA 2.091 L/kg 1compartment NA NA Human Human -DTXSID0023747 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023747 TK.Half.Life NA 1.821 hours 1compartment NA NA Human Human -DTXSID0023747 Css NA 0.05624 mg/L 3compartmentss NA 50% Human Human -DTXSID0023747 Css NA 0.5126 mg/L 3compartmentss NA 95% Human Human -DTXSID0023747 Css NA 0.0566 mg/L PBTK NA 50% Human Human -DTXSID0023747 Css NA 0.4057 mg/L PBTK NA 95% Human Human -DTXSID0023747 Clint NA 7.758 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0023747 Vd NA 2.005 L/kg 1compartment NA NA Human Human +DTXSID0023747 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0023747 TK.Half.Life NA 13.52 hours 1compartment NA NA Human Human +DTXSID0023747 Css NA 0.6322 mg/L 3compartmentss NA 50% Human Human +DTXSID0023747 Css NA 4.019 mg/L 3compartmentss NA 95% Human Human +DTXSID0023747 Css NA 0.6408 mg/L PBTK NA 50% Human Human +DTXSID0023747 Css NA 2.889 mg/L PBTK NA 95% Human Human +DTXSID0023747 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0023747 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0023747 Vd NA 2.131 L/kg 1compartment NA NA Rat Human +DTXSID0023747 Vd NA 2.046 L/kg 1compartment NA NA Rat Human DTXSID0023747 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023747 TK.Half.Life NA 0.9828 hours 1compartment NA NA Rat Human -DTXSID0023747 Css NA 0.02666 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023747 Css NA 0.215 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023747 Css NA 0.02718 mg/L PBTK NA 50% Rat Human -DTXSID0023747 Css NA 0.1517 mg/L PBTK NA 95% Rat Human +DTXSID0023747 TK.Half.Life NA 4.699 hours 1compartment NA NA Rat Human +DTXSID0023747 Css NA 0.01607 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023747 Css NA 0.1134 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023747 Css NA 0.01604 mg/L PBTK NA 50% Rat Human +DTXSID0023747 Css NA 0.08132 mg/L PBTK NA 95% Rat Human DTXSID0023749 Clint NA 40.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0023749 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0023749 Vd NA 0.6945 L/kg 1compartment NA NA Human Human +DTXSID0023749 Vd NA 0.6244 L/kg 1compartment NA NA Human Human DTXSID0023749 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023749 TK.Half.Life NA 0.479 hours 1compartment NA NA Human Human -DTXSID0023749 Css NA 0.01536 mg/L 3compartmentss NA 50% Human Human -DTXSID0023749 Css NA 0.161 mg/L 3compartmentss NA 95% Human Human -DTXSID0023749 Css NA 0.01226 mg/L PBTK NA 50% Human Human -DTXSID0023749 Css NA 0.1118 mg/L PBTK NA 95% Human Human +DTXSID0023749 TK.Half.Life NA 0.4351 hours 1compartment NA NA Human Human +DTXSID0023749 Css NA 0.009 mg/L 3compartmentss NA 50% Human Human +DTXSID0023749 Css NA 0.1294 mg/L 3compartmentss NA 95% Human Human +DTXSID0023749 Css NA 0.00705 mg/L PBTK NA 50% Human Human +DTXSID0023749 Css NA 0.08887 mg/L PBTK NA 95% Human Human DTXSID0023749 Clint NA 40.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0023749 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0023749 Vd NA 0.731 L/kg 1compartment NA NA Rat Human +DTXSID0023749 Vd NA 0.6728 L/kg 1compartment NA NA Rat Human DTXSID0023749 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023749 TK.Half.Life NA 0.2325 hours 1compartment NA NA Rat Human -DTXSID0023749 Css NA 0.007896 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023749 Css NA 0.06856 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023749 Css NA 0.006199 mg/L PBTK NA 50% Rat Human -DTXSID0023749 Css NA 0.04675 mg/L PBTK NA 95% Rat Human -DTXSID0023826 Clint NA 10.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023826 Fup NA 0.321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023826 Vd NA 1.271 L/kg 1compartment NA NA Human Human -DTXSID0023826 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023826 TK.Half.Life NA 2.431 hours 1compartment NA NA Human Human -DTXSID0023826 Css NA 0.1469 mg/L 3compartmentss NA 50% Human Human -DTXSID0023826 Css NA 0.9834 mg/L 3compartmentss NA 95% Human Human -DTXSID0023826 Css NA 0.112 mg/L PBTK NA 50% Human Human -DTXSID0023826 Css NA 0.6803 mg/L PBTK NA 95% Human Human -DTXSID0023826 Clint NA 10.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023826 Fup NA 0.321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023826 Vd NA 1.058 L/kg 1compartment NA NA Rat Human +DTXSID0023749 TK.Half.Life NA 0.2147 hours 1compartment NA NA Rat Human +DTXSID0023749 Css NA 0.000315 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023749 Css NA 0.005147 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023749 Css NA 0.0002421 mg/L PBTK NA 50% Rat Human +DTXSID0023749 Css NA 0.003453 mg/L PBTK NA 95% Rat Human +DTXSID0023826 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023826 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023826 Vd NA 1.329 L/kg 1compartment NA NA Human Human +DTXSID0023826 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0023826 TK.Half.Life NA 28.23 hours 1compartment NA NA Human Human +DTXSID0023826 Css NA 2.168 mg/L 3compartmentss NA 50% Human Human +DTXSID0023826 Css NA 9.077 mg/L 3compartmentss NA 95% Human Human +DTXSID0023826 Css NA 1.692 mg/L PBTK NA 50% Human Human +DTXSID0023826 Css NA 5.997 mg/L PBTK NA 95% Human Human +DTXSID0023826 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023826 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023826 Vd NA 1.11 L/kg 1compartment NA NA Rat Human DTXSID0023826 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023826 TK.Half.Life NA 1.057 hours 1compartment NA NA Rat Human -DTXSID0023826 Css NA 0.07698 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023826 Css NA 0.3797 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023826 Css NA 0.05635 mg/L PBTK NA 50% Rat Human -DTXSID0023826 Css NA 0.2459 mg/L PBTK NA 95% Rat Human -DTXSID0023870 Clint NA 0.9115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0023826 TK.Half.Life NA 7.078 hours 1compartment NA NA Rat Human +DTXSID0023826 Css NA 0.1371 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023826 Css NA 0.4831 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023826 Css NA 0.1068 mg/L PBTK NA 50% Rat Human +DTXSID0023826 Css NA 0.3068 mg/L PBTK NA 95% Rat Human +DTXSID00238609 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00238609 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00238609 Vd NA 2.172 L/kg 1compartment NA NA Human Human +DTXSID00238609 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00238609 TK.Half.Life NA 7.276 hours 1compartment NA NA Human Human +DTXSID00238609 Css NA 0.2583 mg/L 3compartmentss NA 50% Human Human +DTXSID00238609 Css NA 1.638 mg/L 3compartmentss NA 95% Human Human +DTXSID00238609 Css NA 0.2482 mg/L PBTK NA 50% Human Human +DTXSID00238609 Css NA 1.266 mg/L PBTK NA 95% Human Human +DTXSID00238609 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00238609 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00238609 Vd NA 2.193 L/kg 1compartment NA NA Rat Human +DTXSID00238609 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00238609 TK.Half.Life NA 4.143 hours 1compartment NA NA Rat Human +DTXSID00238609 Css NA 0.0278 mg/L 3compartmentss NA 50% Rat Human +DTXSID00238609 Css NA 0.1377 mg/L 3compartmentss NA 95% Rat Human +DTXSID00238609 Css NA 0.02726 mg/L PBTK NA 50% Rat Human +DTXSID00238609 Css NA 0.09956 mg/L PBTK NA 95% Rat Human +DTXSID0023870 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0023870 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0023870 Vd NA 2.984 L/kg 1compartment NA NA Human Human -DTXSID0023870 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023870 TK.Half.Life NA 8.111 hours 1compartment NA NA Human Human -DTXSID0023870 Css NA 0.2436 mg/L 3compartmentss NA 50% Human Human -DTXSID0023870 Css NA 2.027 mg/L 3compartmentss NA 95% Human Human -DTXSID0023870 Css NA 0.2845 mg/L PBTK NA 50% Human Human -DTXSID0023870 Css NA 1.518 mg/L PBTK NA 95% Human Human -DTXSID0023870 Clint NA 0.9115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0023870 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0023870 TK.Half.Life NA 19.33 hours 1compartment NA NA Human Human +DTXSID0023870 Css NA 0.5024 mg/L 3compartmentss NA 50% Human Human +DTXSID0023870 Css NA 4.33 mg/L 3compartmentss NA 95% Human Human +DTXSID0023870 Css NA 0.5918 mg/L PBTK NA 50% Human Human +DTXSID0023870 Css NA 3.169 mg/L PBTK NA 95% Human Human +DTXSID0023870 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0023870 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0023870 Vd NA 3.042 L/kg 1compartment NA NA Rat Human DTXSID0023870 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023870 TK.Half.Life NA 3.961 hours 1compartment NA NA Rat Human -DTXSID0023870 Css NA 0.08569 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023870 Css NA 0.6968 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023870 Css NA 0.1021 mg/L PBTK NA 50% Rat Human -DTXSID0023870 Css NA 0.479 mg/L PBTK NA 95% Rat Human +DTXSID0023870 TK.Half.Life NA 6.71 hours 1compartment NA NA Rat Human +DTXSID0023870 Css NA 0.008934 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023870 Css NA 0.08615 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023870 Css NA 0.01049 mg/L PBTK NA 50% Rat Human +DTXSID0023870 Css NA 0.06695 mg/L PBTK NA 95% Rat Human DTXSID0023901 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0023901 Fup 0.02147 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0023901 Vd NA 0.5299 L/kg 1compartment NA NA Human Human DTXSID0023901 Days.Css NA 37 Days PBTK NA NA Human Human DTXSID0023901 TK.Half.Life NA 161.5 hours 1compartment NA NA Human Human -DTXSID0023901 Css NA 44.02 mg/L 3compartmentss NA 50% Human Human -DTXSID0023901 Css NA 300.5 mg/L 3compartmentss NA 95% Human Human -DTXSID0023901 Css NA 30.82 mg/L PBTK NA 50% Human Human -DTXSID0023901 Css NA 180.6 mg/L PBTK NA 95% Human Human +DTXSID0023901 Css NA 41.88 mg/L 3compartmentss NA 50% Human Human +DTXSID0023901 Css NA 249.5 mg/L 3compartmentss NA 95% Human Human +DTXSID0023901 Css NA 29.64 mg/L PBTK NA 50% Human Human +DTXSID0023901 Css NA 176.7 mg/L PBTK NA 95% Human Human DTXSID0023901 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0023901 Fup 0.09856 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0023901 Vd NA 1.199 L/kg 1compartment NA NA Rat Rat DTXSID0023901 Days.Css NA 4 Days PBTK NA NA Rat Rat DTXSID0023901 TK.Half.Life NA 27.15 hours 1compartment NA NA Rat Rat -DTXSID0023901 Css NA 2.67 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0023901 Css NA 10.93 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0023901 Css NA 1.758 mg/L PBTK NA 50% Rat Rat -DTXSID0023901 Css NA 6.266 mg/L PBTK NA 95% Rat Rat +DTXSID0023901 Css NA 0.5572 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0023901 Css NA 2 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0023901 Css NA 0.4084 mg/L PBTK NA 50% Rat Rat +DTXSID0023901 Css NA 1.467 mg/L PBTK NA 95% Rat Rat DTXSID0023907 Clint 5.564 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0023907 Fup 0.01059 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID0023907 Vd NA 21.5 L/kg 1compartment NA NA Human Human -DTXSID0023907 Days.Css NA 635 Days PBTK NA NA Human Human -DTXSID0023907 TK.Half.Life NA 2356 hours 1compartment NA NA Human Human -DTXSID0023907 Css NA 0.6244 mg/L 3compartmentss NA 50% Human Human -DTXSID0023907 Css NA 4.446 mg/L 3compartmentss NA 95% Human Human -DTXSID0023907 Css NA 9.57 mg/L PBTK NA 50% Human Human -DTXSID0023907 Css NA 54.04 mg/L PBTK NA 95% Human Human +DTXSID0023907 Vd NA 16.51 L/kg 1compartment NA NA Human Human +DTXSID0023907 Days.Css NA 512 Days PBTK NA NA Human Human +DTXSID0023907 TK.Half.Life NA 1900 hours 1compartment NA NA Human Human +DTXSID0023907 Css NA 0.9207 mg/L 3compartmentss NA 50% Human Human +DTXSID0023907 Css NA 5.735 mg/L 3compartmentss NA 95% Human Human +DTXSID0023907 Css NA 9.306 mg/L PBTK NA 50% Human Human +DTXSID0023907 Css NA 53.96 mg/L PBTK NA 95% Human Human DTXSID0023907 Clint 5.564 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0023907 Fup 0.01059 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID0023907 Vd NA 21.78 L/kg 1compartment NA NA Rat Human -DTXSID0023907 Days.Css NA 447 Days PBTK NA NA Rat Human -DTXSID0023907 TK.Half.Life NA 424.7 hours 1compartment NA NA Rat Human -DTXSID0023907 Css NA 0.3026 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023907 Css NA 1.735 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023907 Css NA 5.13 mg/L PBTK NA 50% Rat Human -DTXSID0023907 Css NA 22.73 mg/L PBTK NA 95% Rat Human -DTXSID0023909 Clint NA 44.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023909 Fup NA 0.0223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023909 Vd NA 3.701 L/kg 1compartment NA NA Human Human -DTXSID0023909 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID0023909 TK.Half.Life NA 56.22 hours 1compartment NA NA Human Human -DTXSID0023909 Css NA 1.63 mg/L 3compartmentss NA 50% Human Human -DTXSID0023909 Css NA 9.266 mg/L 3compartmentss NA 95% Human Human -DTXSID0023909 Css NA 1.194 mg/L PBTK NA 50% Human Human -DTXSID0023909 Css NA 6.756 mg/L PBTK NA 95% Human Human -DTXSID0023909 Clint NA 44.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023909 Fup NA 0.0223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023909 Vd NA 2.792 L/kg 1compartment NA NA Rat Human -DTXSID0023909 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID0023909 TK.Half.Life NA 7.816 hours 1compartment NA NA Rat Human -DTXSID0023909 Css NA 0.9212 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023909 Css NA 3.994 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023909 Css NA 0.6442 mg/L PBTK NA 50% Rat Human -DTXSID0023909 Css NA 2.834 mg/L PBTK NA 95% Rat Human +DTXSID0023907 Vd NA 16.2 L/kg 1compartment NA NA Rat Human +DTXSID0023907 Days.Css NA 349 Days PBTK NA NA Rat Human +DTXSID0023907 TK.Half.Life NA 323.9 hours 1compartment NA NA Rat Human +DTXSID0023907 Css NA 0.1084 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023907 Css NA 0.5102 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023907 Css NA 1.213 mg/L PBTK NA 50% Rat Human +DTXSID0023907 Css NA 5.793 mg/L PBTK NA 95% Rat Human +DTXSID0023909 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023909 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023909 Vd NA 5.399 L/kg 1compartment NA NA Human Human +DTXSID0023909 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID0023909 TK.Half.Life NA 162.1 hours 1compartment NA NA Human Human +DTXSID0023909 Css NA 2.822 mg/L 3compartmentss NA 50% Human Human +DTXSID0023909 Css NA 17.02 mg/L 3compartmentss NA 95% Human Human +DTXSID0023909 Css NA 2.361 mg/L PBTK NA 50% Human Human +DTXSID0023909 Css NA 14.03 mg/L PBTK NA 95% Human Human +DTXSID0023909 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023909 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023909 Vd NA 4.136 L/kg 1compartment NA NA Rat Human +DTXSID0023909 Days.Css NA 17 Days PBTK NA NA Rat Human +DTXSID0023909 TK.Half.Life NA 22 hours 1compartment NA NA Rat Human +DTXSID0023909 Css NA 0.3634 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023909 Css NA 1.701 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023909 Css NA 0.3076 mg/L PBTK NA 50% Rat Human +DTXSID0023909 Css NA 1.477 mg/L PBTK NA 95% Rat Human +DTXSID00239373 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00239373 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00239373 Vd NA 1.838 L/kg 1compartment NA NA Human Human +DTXSID00239373 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00239373 TK.Half.Life NA 2.118 hours 1compartment NA NA Human Human +DTXSID00239373 Css NA 0.05478 mg/L 3compartmentss NA 50% Human Human +DTXSID00239373 Css NA 0.4238 mg/L 3compartmentss NA 95% Human Human +DTXSID00239373 Css NA 0.04447 mg/L PBTK NA 50% Human Human +DTXSID00239373 Css NA 0.3053 mg/L PBTK NA 95% Human Human +DTXSID00239373 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00239373 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00239373 Vd NA 1.49 L/kg 1compartment NA NA Rat Human +DTXSID00239373 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00239373 TK.Half.Life NA 0.7902 hours 1compartment NA NA Rat Human +DTXSID00239373 Css NA 0.006732 mg/L 3compartmentss NA 50% Rat Human +DTXSID00239373 Css NA 0.04002 mg/L 3compartmentss NA 95% Rat Human +DTXSID00239373 Css NA 0.005541 mg/L PBTK NA 50% Rat Human +DTXSID00239373 Css NA 0.02906 mg/L PBTK NA 95% Rat Human DTXSID0023951 Clint 24.41 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0023951 Fup 0.175 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0023951 Vd NA 1.145 L/kg 1compartment NA NA Human Human DTXSID0023951 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0023951 TK.Half.Life NA 1.98 hours 1compartment NA NA Human Human -DTXSID0023951 Css NA 0.1261 mg/L 3compartmentss NA 50% Human Human -DTXSID0023951 Css NA 0.8648 mg/L 3compartmentss NA 95% Human Human -DTXSID0023951 Css NA 0.08782 mg/L PBTK NA 50% Human Human -DTXSID0023951 Css NA 0.5689 mg/L PBTK NA 95% Human Human +DTXSID0023951 Css NA 0.1178 mg/L 3compartmentss NA 50% Human Human +DTXSID0023951 Css NA 0.919 mg/L 3compartmentss NA 95% Human Human +DTXSID0023951 Css NA 0.0816 mg/L PBTK NA 50% Human Human +DTXSID0023951 Css NA 0.5998 mg/L PBTK NA 95% Human Human DTXSID0023951 Clint 24.41 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0023951 Fup 0.175 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0023951 Vd NA 0.9197 L/kg 1compartment NA NA Rat Human DTXSID0023951 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0023951 TK.Half.Life NA 0.833 hours 1compartment NA NA Rat Human -DTXSID0023951 Css NA 0.06912 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023951 Css NA 0.3653 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023951 Css NA 0.0454 mg/L PBTK NA 50% Rat Human -DTXSID0023951 Css NA 0.2269 mg/L PBTK NA 95% Rat Human -DTXSID0023955 Clint NA 5.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023955 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0023955 Vd NA 0.2551 L/kg 1compartment NA NA Human Human +DTXSID0023951 Css NA 0.01536 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023951 Css NA 0.08697 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023951 Css NA 0.01054 mg/L PBTK NA 50% Rat Human +DTXSID0023951 Css NA 0.05589 mg/L PBTK NA 95% Rat Human +DTXSID0023955 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023955 Fup 0.0868 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0023955 Vd NA 0.3841 L/kg 1compartment NA NA Human Human DTXSID0023955 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0023955 TK.Half.Life NA 5.527 hours 1compartment NA NA Human Human -DTXSID0023955 Css NA 3.859 mg/L 3compartmentss NA 50% Human Human -DTXSID0023955 Css NA 31.47 mg/L 3compartmentss NA 95% Human Human -DTXSID0023955 Css NA 2.327 mg/L PBTK NA 50% Human Human -DTXSID0023955 Css NA 18.52 mg/L PBTK NA 95% Human Human -DTXSID0023955 Clint NA 5.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023955 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0023955 Vd NA 0.2499 L/kg 1compartment NA NA Rat Human +DTXSID0023955 TK.Half.Life NA 2.805 hours 1compartment NA NA Human Human +DTXSID0023955 Css NA 0.9375 mg/L 3compartmentss NA 50% Human Human +DTXSID0023955 Css NA 6.797 mg/L 3compartmentss NA 95% Human Human +DTXSID0023955 Css NA 0.5961 mg/L PBTK NA 50% Human Human +DTXSID0023955 Css NA 4.095 mg/L PBTK NA 95% Human Human +DTXSID0023955 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023955 Fup 0.0868 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0023955 Vd NA 0.3781 L/kg 1compartment NA NA Rat Human DTXSID0023955 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0023955 TK.Half.Life NA 3.383 hours 1compartment NA NA Rat Human -DTXSID0023955 Css NA 2.056 mg/L 3compartmentss NA 50% Rat Human -DTXSID0023955 Css NA 12.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID0023955 Css NA 1.155 mg/L PBTK NA 50% Rat Human -DTXSID0023955 Css NA 6.656 mg/L PBTK NA 95% Rat Human +DTXSID0023955 TK.Half.Life NA 1.696 hours 1compartment NA NA Rat Human +DTXSID0023955 Css NA 0.04155 mg/L 3compartmentss NA 50% Rat Human +DTXSID0023955 Css NA 0.3329 mg/L 3compartmentss NA 95% Rat Human +DTXSID0023955 Css NA 0.02554 mg/L PBTK NA 50% Rat Human +DTXSID0023955 Css NA 0.1921 mg/L PBTK NA 95% Rat Human DTXSID0024000 Clint 38.62 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0024000 Fup 0.01666 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID0024000 Vd NA 2.495 L/kg 1compartment NA NA Human Human DTXSID0024000 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID0024000 TK.Half.Life NA 20.2 hours 1compartment NA NA Human Human -DTXSID0024000 Css NA 1.108 mg/L 3compartmentss NA 50% Human Human -DTXSID0024000 Css NA 8.283 mg/L 3compartmentss NA 95% Human Human -DTXSID0024000 Css NA 0.7293 mg/L PBTK NA 50% Human Human -DTXSID0024000 Css NA 5.256 mg/L PBTK NA 95% Human Human +DTXSID0024000 Css NA 1.074 mg/L 3compartmentss NA 50% Human Human +DTXSID0024000 Css NA 8.56 mg/L 3compartmentss NA 95% Human Human +DTXSID0024000 Css NA 0.7102 mg/L PBTK NA 50% Human Human +DTXSID0024000 Css NA 5.432 mg/L PBTK NA 95% Human Human DTXSID0024000 Clint 38.62 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0024000 Fup 0.01666 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID0024000 Vd NA 1.86 L/kg 1compartment NA NA Rat Human DTXSID0024000 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID0024000 TK.Half.Life NA 5.085 hours 1compartment NA NA Rat Human -DTXSID0024000 Css NA 0.6245 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024000 Css NA 3.828 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024000 Css NA 0.391 mg/L PBTK NA 50% Rat Human -DTXSID0024000 Css NA 2.259 mg/L PBTK NA 95% Rat Human +DTXSID0024000 Css NA 0.1412 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024000 Css NA 0.918 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024000 Css NA 0.09166 mg/L PBTK NA 50% Rat Human +DTXSID0024000 Css NA 0.5781 mg/L PBTK NA 95% Rat Human DTXSID0024002 Clint 19.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0024002 Fup 0.00458 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0024002 Vd NA 3.021 L/kg 1compartment NA NA Human Human DTXSID0024002 Days.Css NA 16 Days PBTK NA NA Human Human DTXSID0024002 TK.Half.Life NA 97.22 hours 1compartment NA NA Human Human -DTXSID0024002 Css NA 4.024 mg/L 3compartmentss NA 50% Human Human -DTXSID0024002 Css NA 23.04 mg/L 3compartmentss NA 95% Human Human -DTXSID0024002 Css NA 2.757 mg/L PBTK NA 50% Human Human -DTXSID0024002 Css NA 15.43 mg/L PBTK NA 95% Human Human +DTXSID0024002 Css NA 3.858 mg/L 3compartmentss NA 50% Human Human +DTXSID0024002 Css NA 22.72 mg/L 3compartmentss NA 95% Human Human +DTXSID0024002 Css NA 2.651 mg/L PBTK NA 50% Human Human +DTXSID0024002 Css NA 15.53 mg/L PBTK NA 95% Human Human DTXSID0024002 Clint 19.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0024002 Fup 0.00458 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0024002 Vd NA 2.261 L/kg 1compartment NA NA Rat Human DTXSID0024002 Days.Css NA 9 Days PBTK NA NA Rat Human DTXSID0024002 TK.Half.Life NA 14.8 hours 1compartment NA NA Rat Human -DTXSID0024002 Css NA 2.211 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024002 Css NA 10.76 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024002 Css NA 1.454 mg/L PBTK NA 50% Rat Human -DTXSID0024002 Css NA 6.899 mg/L PBTK NA 95% Rat Human -DTXSID0024052 Clint NA 0.04784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0024002 Css NA 0.503 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024002 Css NA 2.65 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024002 Css NA 0.3433 mg/L PBTK NA 50% Rat Human +DTXSID0024002 Css NA 1.81 mg/L PBTK NA 95% Rat Human +DTXSID0024052 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0024052 Fup 0.937 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0024052 Vd NA 0.8722 L/kg 1compartment NA NA Human Human DTXSID0024052 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024052 TK.Half.Life NA 5.608 hours 1compartment NA NA Human Human -DTXSID0024052 Css NA 0.7082 mg/L 3compartmentss NA 50% Human Human -DTXSID0024052 Css NA 2.056 mg/L 3compartmentss NA 95% Human Human -DTXSID0024052 Css NA 0.6195 mg/L PBTK NA 50% Human Human -DTXSID0024052 Css NA 1.571 mg/L PBTK NA 95% Human Human -DTXSID0024052 Clint NA 0.04784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0024052 TK.Half.Life NA 6.048 hours 1compartment NA NA Human Human +DTXSID0024052 Css NA 0.755 mg/L 3compartmentss NA 50% Human Human +DTXSID0024052 Css NA 2.164 mg/L 3compartmentss NA 95% Human Human +DTXSID0024052 Css NA 0.6566 mg/L PBTK NA 50% Human Human +DTXSID0024052 Css NA 1.642 mg/L PBTK NA 95% Human Human +DTXSID0024052 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0024052 Fup 0.937 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0024052 Vd NA 0.8904 L/kg 1compartment NA NA Rat Human DTXSID0024052 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024052 TK.Half.Life NA 2.02 hours 1compartment NA NA Rat Human -DTXSID0024052 Css NA 0.1924 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024052 Css NA 0.4575 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024052 Css NA 0.1652 mg/L PBTK NA 50% Rat Human -DTXSID0024052 Css NA 0.3219 mg/L PBTK NA 95% Rat Human +DTXSID0024052 TK.Half.Life NA 2.097 hours 1compartment NA NA Rat Human +DTXSID0024052 Css NA 0.04523 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024052 Css NA 0.1062 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024052 Css NA 0.04024 mg/L PBTK NA 50% Rat Human +DTXSID0024052 Css NA 0.07761 mg/L PBTK NA 95% Rat Human +DTXSID0024216 Clint 238 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID0024216 Fup 5.81e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID0024216 Vd NA 0.1924 L/kg 1compartment NA NA Human Human +DTXSID0024216 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0024216 TK.Half.Life NA 21.55 hours 1compartment NA NA Human Human +DTXSID0024216 Css NA 0.2246 mg/L 3compartmentss NA 50% Human Human +DTXSID0024216 Css NA 4.227 mg/L 3compartmentss NA 95% Human Human +DTXSID0024216 Css NA 0.1362 mg/L PBTK NA 50% Human Human +DTXSID0024216 Css NA 2.476 mg/L PBTK NA 95% Human Human +DTXSID0024216 Clint 238 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID0024216 Fup 5.81e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID0024216 Vd NA 0.1745 L/kg 1compartment NA NA Rat Human +DTXSID0024216 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0024216 TK.Half.Life NA 13.65 hours 1compartment NA NA Rat Human +DTXSID0024216 Css NA 0.02962 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024216 Css NA 0.47 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024216 Css NA 0.01761 mg/L PBTK NA 50% Rat Human +DTXSID0024216 Css NA 0.2663 mg/L PBTK NA 95% Rat Human DTXSID0024266 Clint 49.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0024266 Fup 0.0134 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0024266 Vd NA 2.282 L/kg 1compartment NA NA Human Human DTXSID0024266 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID0024266 TK.Half.Life NA 15.28 hours 1compartment NA NA Human Human -DTXSID0024266 Css NA 0.7266 mg/L 3compartmentss NA 50% Human Human -DTXSID0024266 Css NA 4.775 mg/L 3compartmentss NA 95% Human Human -DTXSID0024266 Css NA 0.4833 mg/L PBTK NA 50% Human Human -DTXSID0024266 Css NA 3.104 mg/L PBTK NA 95% Human Human +DTXSID0024266 Css NA 0.7009 mg/L 3compartmentss NA 50% Human Human +DTXSID0024266 Css NA 4.914 mg/L 3compartmentss NA 95% Human Human +DTXSID0024266 Css NA 0.4643 mg/L PBTK NA 50% Human Human +DTXSID0024266 Css NA 3.117 mg/L PBTK NA 95% Human Human DTXSID0024266 Clint 49.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0024266 Fup 0.0134 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0024266 Vd NA 1.697 L/kg 1compartment NA NA Rat Human DTXSID0024266 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0024266 TK.Half.Life NA 4.351 hours 1compartment NA NA Rat Human -DTXSID0024266 Css NA 0.4047 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024266 Css NA 2.286 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024266 Css NA 0.2552 mg/L PBTK NA 50% Rat Human -DTXSID0024266 Css NA 1.399 mg/L PBTK NA 95% Rat Human -DTXSID0024341 Clint NA 9.928 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024341 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024341 Vd NA 1.382 L/kg 1compartment NA NA Human Human -DTXSID0024341 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024341 TK.Half.Life NA 2.735 hours 1compartment NA NA Human Human -DTXSID0024341 Css NA 0.1568 mg/L 3compartmentss NA 50% Human Human -DTXSID0024341 Css NA 1.032 mg/L 3compartmentss NA 95% Human Human -DTXSID0024341 Css NA 0.1193 mg/L PBTK NA 50% Human Human -DTXSID0024341 Css NA 0.7091 mg/L PBTK NA 95% Human Human -DTXSID0024341 Clint NA 9.928 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024341 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024341 Vd NA 1.135 L/kg 1compartment NA NA Rat Human -DTXSID0024341 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024341 TK.Half.Life NA 1.152 hours 1compartment NA NA Rat Human -DTXSID0024341 Css NA 0.0808 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024341 Css NA 0.394 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024341 Css NA 0.05923 mg/L PBTK NA 50% Rat Human -DTXSID0024341 Css NA 0.2594 mg/L PBTK NA 95% Rat Human +DTXSID0024266 Css NA 0.09041 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024266 Css NA 0.5429 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024266 Css NA 0.05936 mg/L PBTK NA 50% Rat Human +DTXSID0024266 Css NA 0.3486 mg/L PBTK NA 95% Rat Human DTXSID0024345 Clint 14.58 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0024345 Fup 0.02305 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0024345 Vd NA 0.1862 L/kg 1compartment NA NA Human Human DTXSID0024345 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0024345 TK.Half.Life NA 2.224 hours 1compartment NA NA Human Human -DTXSID0024345 Css NA 2.13 mg/L 3compartmentss NA 50% Human Human -DTXSID0024345 Css NA 19.29 mg/L 3compartmentss NA 95% Human Human -DTXSID0024345 Css NA 1.251 mg/L PBTK NA 50% Human Human -DTXSID0024345 Css NA 11.27 mg/L PBTK NA 95% Human Human +DTXSID0024345 Css NA 1.83 mg/L 3compartmentss NA 50% Human Human +DTXSID0024345 Css NA 16.66 mg/L 3compartmentss NA 95% Human Human +DTXSID0024345 Css NA 1.076 mg/L PBTK NA 50% Human Human +DTXSID0024345 Css NA 9.627 mg/L PBTK NA 95% Human Human DTXSID0024345 Clint 14.58 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0024345 Fup 0.02305 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0024345 Vd NA 0.1845 L/kg 1compartment NA NA Rat Human DTXSID0024345 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0024345 TK.Half.Life NA 1.441 hours 1compartment NA NA Rat Human -DTXSID0024345 Css NA 1.185 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024345 Css NA 8.859 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024345 Css NA 0.649 mg/L PBTK NA 50% Rat Human -DTXSID0024345 Css NA 4.802 mg/L PBTK NA 95% Rat Human -DTXSID0024395 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024395 Fup NA 0.9303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024395 Vd NA 0.9645 L/kg 1compartment NA NA Human Human +DTXSID0024345 Css NA 0.0895 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024345 Css NA 0.9539 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024345 Css NA 0.04996 mg/L PBTK NA 50% Rat Human +DTXSID0024345 Css NA 0.5314 mg/L PBTK NA 95% Rat Human +DTXSID0024395 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024395 Fup 0.679 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024395 Vd NA 0.7025 L/kg 1compartment NA NA Human Human DTXSID0024395 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024395 TK.Half.Life NA 6.782 hours 1compartment NA NA Human Human -DTXSID0024395 Css NA 0.8274 mg/L 3compartmentss NA 50% Human Human -DTXSID0024395 Css NA 3.084 mg/L 3compartmentss NA 95% Human Human -DTXSID0024395 Css NA 0.7248 mg/L PBTK NA 50% Human Human -DTXSID0024395 Css NA 2.244 mg/L PBTK NA 95% Human Human -DTXSID0024395 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024395 Fup NA 0.9303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024395 Vd NA 0.965 L/kg 1compartment NA NA Rat Human +DTXSID0024395 TK.Half.Life NA 6.71 hours 1compartment NA NA Human Human +DTXSID0024395 Css NA 0.956 mg/L 3compartmentss NA 50% Human Human +DTXSID0024395 Css NA 6.142 mg/L 3compartmentss NA 95% Human Human +DTXSID0024395 Css NA 0.7748 mg/L PBTK NA 50% Human Human +DTXSID0024395 Css NA 3.862 mg/L PBTK NA 95% Human Human +DTXSID0024395 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024395 Fup 0.679 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024395 Vd NA 0.7185 L/kg 1compartment NA NA Rat Human DTXSID0024395 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024395 TK.Half.Life NA 2.293 hours 1compartment NA NA Rat Human -DTXSID0024395 Css NA 0.2126 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024395 Css NA 0.7559 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024395 Css NA 0.1828 mg/L PBTK NA 50% Rat Human -DTXSID0024395 Css NA 0.4971 mg/L PBTK NA 95% Rat Human -DTXSID0024397 Clint NA 0.9978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024397 Fup NA 0.6147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024397 Vd NA 1.133 L/kg 1compartment NA NA Human Human +DTXSID0024395 TK.Half.Life NA 2.335 hours 1compartment NA NA Rat Human +DTXSID0024395 Css NA 0.01819 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024395 Css NA 0.1483 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024395 Css NA 0.01419 mg/L PBTK NA 50% Rat Human +DTXSID0024395 Css NA 0.09453 mg/L PBTK NA 95% Rat Human +DTXSID0024397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024397 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024397 Vd NA 0.7122 L/kg 1compartment NA NA Human Human DTXSID0024397 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024397 TK.Half.Life NA 5.008 hours 1compartment NA NA Human Human -DTXSID0024397 Css NA 0.446 mg/L 3compartmentss NA 50% Human Human -DTXSID0024397 Css NA 3.148 mg/L 3compartmentss NA 95% Human Human -DTXSID0024397 Css NA 0.3834 mg/L PBTK NA 50% Human Human -DTXSID0024397 Css NA 2.058 mg/L PBTK NA 95% Human Human -DTXSID0024397 Clint NA 0.9978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024397 Fup NA 0.6147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024397 Vd NA 1.035 L/kg 1compartment NA NA Rat Human +DTXSID0024397 TK.Half.Life NA 0.8551 hours 1compartment NA NA Human Human +DTXSID0024397 Css NA 0.05616 mg/L 3compartmentss NA 50% Human Human +DTXSID0024397 Css NA 0.4309 mg/L 3compartmentss NA 95% Human Human +DTXSID0024397 Css NA 0.04146 mg/L PBTK NA 50% Human Human +DTXSID0024397 Css NA 0.292 mg/L PBTK NA 95% Human Human +DTXSID0024397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024397 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024397 Vd NA 0.6671 L/kg 1compartment NA NA Rat Human DTXSID0024397 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024397 TK.Half.Life NA 2.129 hours 1compartment NA NA Rat Human -DTXSID0024397 Css NA 0.1735 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024397 Css NA 1.204 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024397 Css NA 0.1451 mg/L PBTK NA 50% Rat Human -DTXSID0024397 Css NA 0.7194 mg/L PBTK NA 95% Rat Human +DTXSID0024397 TK.Half.Life NA 0.4171 hours 1compartment NA NA Rat Human +DTXSID0024397 Css NA 0.00705 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024397 Css NA 0.04177 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024397 Css NA 0.005219 mg/L PBTK NA 50% Rat Human +DTXSID0024397 Css NA 0.028 mg/L PBTK NA 95% Rat Human DTXSID0024399 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0024399 Fup NA 0.9322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024399 Vd NA 0.8678 L/kg 1compartment NA NA Human Human +DTXSID0024399 Vd NA 0.9256 L/kg 1compartment NA NA Human Human DTXSID0024399 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024399 TK.Half.Life NA 6.048 hours 1compartment NA NA Human Human -DTXSID0024399 Css NA 0.8452 mg/L 3compartmentss NA 50% Human Human -DTXSID0024399 Css NA 3.127 mg/L 3compartmentss NA 95% Human Human -DTXSID0024399 Css NA 0.7245 mg/L PBTK NA 50% Human Human -DTXSID0024399 Css NA 2.191 mg/L PBTK NA 95% Human Human +DTXSID0024399 TK.Half.Life NA 6.478 hours 1compartment NA NA Human Human +DTXSID0024399 Css NA 0.7068 mg/L 3compartmentss NA 50% Human Human +DTXSID0024399 Css NA 2.704 mg/L 3compartmentss NA 95% Human Human +DTXSID0024399 Css NA 0.6152 mg/L PBTK NA 50% Human Human +DTXSID0024399 Css NA 1.953 mg/L PBTK NA 95% Human Human DTXSID0024399 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0024399 Fup NA 0.9322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024399 Vd NA 0.8852 L/kg 1compartment NA NA Rat Human +DTXSID0024399 Vd NA 0.9335 L/kg 1compartment NA NA Rat Human DTXSID0024399 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024399 TK.Half.Life NA 2.095 hours 1compartment NA NA Rat Human -DTXSID0024399 Css NA 0.2176 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024399 Css NA 0.7386 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024399 Css NA 0.1827 mg/L PBTK NA 50% Rat Human -DTXSID0024399 Css NA 0.4826 mg/L PBTK NA 95% Rat Human -DTXSID0024470 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024470 Fup NA 0.162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024470 Vd NA 0.8127 L/kg 1compartment NA NA Human Human +DTXSID0024399 TK.Half.Life NA 2.212 hours 1compartment NA NA Rat Human +DTXSID0024399 Css NA 0.01294 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024399 Css NA 0.07021 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024399 Css NA 0.0109 mg/L PBTK NA 50% Rat Human +DTXSID0024399 Css NA 0.05185 mg/L PBTK NA 95% Rat Human +DTXSID0024470 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024470 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024470 Vd NA 0.8075 L/kg 1compartment NA NA Human Human DTXSID0024470 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024470 TK.Half.Life NA 4.245 hours 1compartment NA NA Human Human -DTXSID0024470 Css NA 0.6293 mg/L 3compartmentss NA 50% Human Human -DTXSID0024470 Css NA 3.687 mg/L 3compartmentss NA 95% Human Human -DTXSID0024470 Css NA 0.4226 mg/L PBTK NA 50% Human Human -DTXSID0024470 Css NA 2.296 mg/L PBTK NA 95% Human Human -DTXSID0024470 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024470 Fup NA 0.162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024470 Vd NA 0.6802 L/kg 1compartment NA NA Rat Human +DTXSID0024470 TK.Half.Life NA 1.372 hours 1compartment NA NA Human Human +DTXSID0024470 Css NA 0.1118 mg/L 3compartmentss NA 50% Human Human +DTXSID0024470 Css NA 0.8243 mg/L 3compartmentss NA 95% Human Human +DTXSID0024470 Css NA 0.07702 mg/L PBTK NA 50% Human Human +DTXSID0024470 Css NA 0.535 mg/L PBTK NA 95% Human Human +DTXSID0024470 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024470 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024470 Vd NA 0.6872 L/kg 1compartment NA NA Rat Human DTXSID0024470 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024470 TK.Half.Life NA 2.019 hours 1compartment NA NA Rat Human -DTXSID0024470 Css NA 0.3209 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024470 Css NA 1.428 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024470 Css NA 0.2047 mg/L PBTK NA 50% Rat Human -DTXSID0024470 Css NA 0.8299 mg/L PBTK NA 95% Rat Human -DTXSID0024474 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024474 Fup NA 0.3218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024474 Vd NA 0.2915 L/kg 1compartment NA NA Human Human +DTXSID0024470 TK.Half.Life NA 0.6359 hours 1compartment NA NA Rat Human +DTXSID0024470 Css NA 0.01443 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024470 Css NA 0.07538 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024470 Css NA 0.009755 mg/L PBTK NA 50% Rat Human +DTXSID0024470 Css NA 0.04781 mg/L PBTK NA 95% Rat Human +DTXSID0024474 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024474 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024474 Vd NA 0.2899 L/kg 1compartment NA NA Human Human DTXSID0024474 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024474 TK.Half.Life NA 5.859 hours 1compartment NA NA Human Human -DTXSID0024474 Css NA 2.539 mg/L 3compartmentss NA 50% Human Human -DTXSID0024474 Css NA 9.735 mg/L 3compartmentss NA 95% Human Human -DTXSID0024474 Css NA 1.656 mg/L PBTK NA 50% Human Human -DTXSID0024474 Css NA 5.889 mg/L PBTK NA 95% Human Human -DTXSID0024474 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024474 Fup NA 0.3218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024474 Vd NA 0.3025 L/kg 1compartment NA NA Rat Human +DTXSID0024474 TK.Half.Life NA 6.897 hours 1compartment NA NA Human Human +DTXSID0024474 Css NA 1.612 mg/L 3compartmentss NA 50% Human Human +DTXSID0024474 Css NA 6.483 mg/L 3compartmentss NA 95% Human Human +DTXSID0024474 Css NA 1.044 mg/L PBTK NA 50% Human Human +DTXSID0024474 Css NA 3.924 mg/L PBTK NA 95% Human Human +DTXSID0024474 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024474 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024474 Vd NA 0.2971 L/kg 1compartment NA NA Rat Human DTXSID0024474 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024474 TK.Half.Life NA 2.072 hours 1compartment NA NA Rat Human -DTXSID0024474 Css NA 0.7054 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024474 Css NA 2.257 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024474 Css NA 0.434 mg/L PBTK NA 50% Rat Human -DTXSID0024474 Css NA 1.277 mg/L PBTK NA 95% Rat Human -DTXSID0024478 Clint NA 6.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024478 Fup NA 0.1533 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024478 Vd NA 1.127 L/kg 1compartment NA NA Human Human +DTXSID0024474 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human +DTXSID0024474 Css NA 0.008748 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024474 Css NA 0.03544 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024474 Css NA 0.005356 mg/L PBTK NA 50% Rat Human +DTXSID0024474 Css NA 0.02035 mg/L PBTK NA 95% Rat Human +DTXSID0024478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024478 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024478 Vd NA 1.025 L/kg 1compartment NA NA Human Human DTXSID0024478 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024478 TK.Half.Life NA 5.403 hours 1compartment NA NA Human Human -DTXSID0024478 Css NA 0.5861 mg/L 3compartmentss NA 50% Human Human -DTXSID0024478 Css NA 3.793 mg/L 3compartmentss NA 95% Human Human -DTXSID0024478 Css NA 0.3982 mg/L PBTK NA 50% Human Human -DTXSID0024478 Css NA 2.4 mg/L PBTK NA 95% Human Human -DTXSID0024478 Clint NA 6.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024478 Fup NA 0.1533 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024478 Vd NA 0.9038 L/kg 1compartment NA NA Rat Human +DTXSID0024478 TK.Half.Life NA 2.279 hours 1compartment NA NA Human Human +DTXSID0024478 Css NA 0.213 mg/L 3compartmentss NA 50% Human Human +DTXSID0024478 Css NA 1.68 mg/L 3compartmentss NA 95% Human Human +DTXSID0024478 Css NA 0.1404 mg/L PBTK NA 50% Human Human +DTXSID0024478 Css NA 1.045 mg/L PBTK NA 95% Human Human +DTXSID0024478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024478 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024478 Vd NA 0.8213 L/kg 1compartment NA NA Rat Human DTXSID0024478 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024478 TK.Half.Life NA 2.366 hours 1compartment NA NA Rat Human -DTXSID0024478 Css NA 0.3055 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024478 Css NA 1.442 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024478 Css NA 0.1966 mg/L PBTK NA 50% Rat Human -DTXSID0024478 Css NA 0.842 mg/L PBTK NA 95% Rat Human -DTXSID0024501 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024501 Fup NA 0.0434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024501 Vd NA 0.268 L/kg 1compartment NA NA Human Human -DTXSID0024501 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID0024501 TK.Half.Life NA 39.95 hours 1compartment NA NA Human Human -DTXSID0024501 Css NA 24.78 mg/L 3compartmentss NA 50% Human Human -DTXSID0024501 Css NA 134 mg/L 3compartmentss NA 95% Human Human -DTXSID0024501 Css NA 14.95 mg/L PBTK NA 50% Human Human -DTXSID0024501 Css NA 78.45 mg/L PBTK NA 95% Human Human -DTXSID0024501 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024501 Fup NA 0.0434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024501 Vd NA 0.2623 L/kg 1compartment NA NA Rat Human -DTXSID0024501 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0024501 TK.Half.Life NA 13.33 hours 1compartment NA NA Rat Human -DTXSID0024501 Css NA 6.966 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024501 Css NA 31.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024501 Css NA 3.942 mg/L PBTK NA 50% Rat Human -DTXSID0024501 Css NA 17.32 mg/L PBTK NA 95% Rat Human -DTXSID0024503 Clint NA 6.817 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024503 Fup NA 0.1913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024503 Vd NA 1.569 L/kg 1compartment NA NA Human Human +DTXSID0024478 TK.Half.Life NA 0.9992 hours 1compartment NA NA Rat Human +DTXSID0024478 Css NA 0.02731 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024478 Css NA 0.1721 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024478 Css NA 0.01769 mg/L PBTK NA 50% Rat Human +DTXSID0024478 Css NA 0.104 mg/L PBTK NA 95% Rat Human +DTXSID0024501 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024501 Fup 0.0561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024501 Vd NA 0.3169 L/kg 1compartment NA NA Human Human +DTXSID0024501 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0024501 TK.Half.Life NA 3.464 hours 1compartment NA NA Human Human +DTXSID0024501 Css NA 1.516 mg/L 3compartmentss NA 50% Human Human +DTXSID0024501 Css NA 11.19 mg/L 3compartmentss NA 95% Human Human +DTXSID0024501 Css NA 0.9362 mg/L PBTK NA 50% Human Human +DTXSID0024501 Css NA 6.662 mg/L PBTK NA 95% Human Human +DTXSID0024501 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024501 Fup 0.0561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024501 Vd NA 0.3111 L/kg 1compartment NA NA Rat Human +DTXSID0024501 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0024501 TK.Half.Life NA 2.118 hours 1compartment NA NA Rat Human +DTXSID0024501 Css NA 0.06984 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024501 Css NA 0.5757 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024501 Css NA 0.04152 mg/L PBTK NA 50% Rat Human +DTXSID0024501 Css NA 0.3291 mg/L PBTK NA 95% Rat Human +DTXSID0024503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024503 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024503 Vd NA 0.9852 L/kg 1compartment NA NA Human Human DTXSID0024503 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024503 TK.Half.Life NA 6.359 hours 1compartment NA NA Human Human -DTXSID0024503 Css NA 0.415 mg/L 3compartmentss NA 50% Human Human -DTXSID0024503 Css NA 2.351 mg/L 3compartmentss NA 95% Human Human -DTXSID0024503 Css NA 0.2969 mg/L PBTK NA 50% Human Human -DTXSID0024503 Css NA 1.571 mg/L PBTK NA 95% Human Human -DTXSID0024503 Clint NA 6.817 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024503 Fup NA 0.1913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024503 Vd NA 1.23 L/kg 1compartment NA NA Rat Human +DTXSID0024503 TK.Half.Life NA 2.335 hours 1compartment NA NA Human Human +DTXSID0024503 Css NA 0.237 mg/L 3compartmentss NA 50% Human Human +DTXSID0024503 Css NA 1.928 mg/L 3compartmentss NA 95% Human Human +DTXSID0024503 Css NA 0.1558 mg/L PBTK NA 50% Human Human +DTXSID0024503 Css NA 1.174 mg/L PBTK NA 95% Human Human +DTXSID0024503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024503 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024503 Vd NA 0.7836 L/kg 1compartment NA NA Rat Human DTXSID0024503 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024503 TK.Half.Life NA 2.458 hours 1compartment NA NA Rat Human -DTXSID0024503 Css NA 0.2142 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024503 Css NA 0.8926 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024503 Css NA 0.147 mg/L PBTK NA 50% Rat Human -DTXSID0024503 Css NA 0.5665 mg/L PBTK NA 95% Rat Human -DTXSID0024505 Clint NA 1.527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024505 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024505 Vd NA 1.641 L/kg 1compartment NA NA Human Human -DTXSID0024505 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024505 TK.Half.Life NA 3.464 hours 1compartment NA NA Human Human -DTXSID0024505 Css NA 0.2096 mg/L 3compartmentss NA 50% Human Human -DTXSID0024505 Css NA 1.594 mg/L 3compartmentss NA 95% Human Human -DTXSID0024505 Css NA 0.202 mg/L PBTK NA 50% Human Human -DTXSID0024505 Css NA 1.128 mg/L PBTK NA 95% Human Human -DTXSID0024505 Clint NA 1.527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024505 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024505 Vd NA 1.643 L/kg 1compartment NA NA Rat Human +DTXSID0024503 TK.Half.Life NA 1.026 hours 1compartment NA NA Rat Human +DTXSID0024503 Css NA 0.03092 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024503 Css NA 0.1954 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024503 Css NA 0.01968 mg/L PBTK NA 50% Rat Human +DTXSID0024503 Css NA 0.1171 mg/L PBTK NA 95% Rat Human +DTXSID0024505 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024505 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024505 Vd NA 1.295 L/kg 1compartment NA NA Human Human +DTXSID0024505 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0024505 TK.Half.Life NA 12.18 hours 1compartment NA NA Human Human +DTXSID0024505 Css NA 0.8367 mg/L 3compartmentss NA 50% Human Human +DTXSID0024505 Css NA 6.049 mg/L 3compartmentss NA 95% Human Human +DTXSID0024505 Css NA 0.7523 mg/L PBTK NA 50% Human Human +DTXSID0024505 Css NA 4.016 mg/L PBTK NA 95% Human Human +DTXSID0024505 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024505 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024505 Vd NA 1.292 L/kg 1compartment NA NA Rat Human DTXSID0024505 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024505 TK.Half.Life NA 1.736 hours 1compartment NA NA Rat Human -DTXSID0024505 Css NA 0.08278 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024505 Css NA 0.6029 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024505 Css NA 0.07996 mg/L PBTK NA 50% Rat Human -DTXSID0024505 Css NA 0.3794 mg/L PBTK NA 95% Rat Human +DTXSID0024505 TK.Half.Life NA 4.104 hours 1compartment NA NA Rat Human +DTXSID0024505 Css NA 0.01627 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024505 Css NA 0.1385 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024505 Css NA 0.01408 mg/L PBTK NA 50% Rat Human +DTXSID0024505 Css NA 0.09275 mg/L PBTK NA 95% Rat Human DTXSID0024507 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0024507 Fup NA 0.5073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024507 Vd NA 0.4111 L/kg 1compartment NA NA Human Human +DTXSID0024507 Vd NA 0.5281 L/kg 1compartment NA NA Human Human DTXSID0024507 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024507 TK.Half.Life NA 5.243 hours 1compartment NA NA Human Human -DTXSID0024507 Css NA 1.533 mg/L 3compartmentss NA 50% Human Human -DTXSID0024507 Css NA 8.022 mg/L 3compartmentss NA 95% Human Human -DTXSID0024507 Css NA 1.104 mg/L PBTK NA 50% Human Human -DTXSID0024507 Css NA 5.022 mg/L PBTK NA 95% Human Human +DTXSID0024507 TK.Half.Life NA 6.736 hours 1compartment NA NA Human Human +DTXSID0024507 Css NA 0.7827 mg/L 3compartmentss NA 50% Human Human +DTXSID0024507 Css NA 4.324 mg/L 3compartmentss NA 95% Human Human +DTXSID0024507 Css NA 0.5953 mg/L PBTK NA 50% Human Human +DTXSID0024507 Css NA 2.715 mg/L PBTK NA 95% Human Human DTXSID0024507 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0024507 Fup NA 0.5073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024507 Vd NA 0.4354 L/kg 1compartment NA NA Rat Human +DTXSID0024507 Vd NA 0.5526 L/kg 1compartment NA NA Rat Human DTXSID0024507 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024507 TK.Half.Life NA 1.892 hours 1compartment NA NA Rat Human -DTXSID0024507 Css NA 0.414 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024507 Css NA 1.872 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024507 Css NA 0.2837 mg/L PBTK NA 50% Rat Human -DTXSID0024507 Css NA 1.082 mg/L PBTK NA 95% Rat Human -DTXSID0024509 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024509 Fup NA 0.6679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024509 Vd NA 0.4413 L/kg 1compartment NA NA Human Human +DTXSID0024507 TK.Half.Life NA 2.402 hours 1compartment NA NA Rat Human +DTXSID0024507 Css NA 0.004174 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024507 Css NA 0.02451 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024507 Css NA 0.003048 mg/L PBTK NA 50% Rat Human +DTXSID0024507 Css NA 0.01475 mg/L PBTK NA 95% Rat Human +DTXSID0024509 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024509 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024509 Vd NA 0.3381 L/kg 1compartment NA NA Human Human DTXSID0024509 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024509 TK.Half.Life NA 4.276 hours 1compartment NA NA Human Human -DTXSID0024509 Css NA 1.254 mg/L 3compartmentss NA 50% Human Human -DTXSID0024509 Css NA 7.276 mg/L 3compartmentss NA 95% Human Human -DTXSID0024509 Css NA 0.9103 mg/L PBTK NA 50% Human Human -DTXSID0024509 Css NA 4.472 mg/L PBTK NA 95% Human Human -DTXSID0024509 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024509 Fup NA 0.6679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024509 Vd NA 0.4583 L/kg 1compartment NA NA Rat Human +DTXSID0024509 TK.Half.Life NA 4.51 hours 1compartment NA NA Human Human +DTXSID0024509 Css NA 1.612 mg/L 3compartmentss NA 50% Human Human +DTXSID0024509 Css NA 7.356 mg/L 3compartmentss NA 95% Human Human +DTXSID0024509 Css NA 1.108 mg/L PBTK NA 50% Human Human +DTXSID0024509 Css NA 4.492 mg/L PBTK NA 95% Human Human +DTXSID0024509 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024509 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024509 Vd NA 0.3572 L/kg 1compartment NA NA Rat Human DTXSID0024509 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024509 TK.Half.Life NA 1.513 hours 1compartment NA NA Rat Human -DTXSID0024509 Css NA 0.3337 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024509 Css NA 1.902 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024509 Css NA 0.2308 mg/L PBTK NA 50% Rat Human -DTXSID0024509 Css NA 1.088 mg/L PBTK NA 95% Rat Human +DTXSID0024509 TK.Half.Life NA 1.624 hours 1compartment NA NA Rat Human +DTXSID0024509 Css NA 0.1023 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024509 Css NA 0.4211 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024509 Css NA 0.06854 mg/L PBTK NA 50% Rat Human +DTXSID0024509 Css NA 0.2482 mg/L PBTK NA 95% Rat Human DTXSID0024553 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0024553 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0024553 Vd NA 0.5343 L/kg 1compartment NA NA Human Human DTXSID0024553 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0024553 TK.Half.Life NA 3.459 hours 1compartment NA NA Human Human -DTXSID0024553 Css NA 0.9164 mg/L 3compartmentss NA 50% Human Human -DTXSID0024553 Css NA 5.678 mg/L 3compartmentss NA 95% Human Human -DTXSID0024553 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID0024553 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID0024553 Css NA 0.7728 mg/L 3compartmentss NA 50% Human Human +DTXSID0024553 Css NA 5.214 mg/L 3compartmentss NA 95% Human Human +DTXSID0024553 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID0024553 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID0024553 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0024553 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0024553 Vd NA 0.567 L/kg 1compartment NA NA Rat Human DTXSID0024553 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0024553 TK.Half.Life NA 1.25 hours 1compartment NA NA Rat Human -DTXSID0024553 Css NA 0.2324 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024553 Css NA 1.372 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024553 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0024553 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0024555 Clint NA 7.774 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024555 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024555 Vd NA 2.416 L/kg 1compartment NA NA Human Human -DTXSID0024555 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID0024555 TK.Half.Life NA 33.75 hours 1compartment NA NA Human Human -DTXSID0024555 Css NA 1.918 mg/L 3compartmentss NA 50% Human Human -DTXSID0024555 Css NA 11.93 mg/L 3compartmentss NA 95% Human Human -DTXSID0024555 Css NA 1.299 mg/L PBTK NA 50% Human Human -DTXSID0024555 Css NA 7.62 mg/L PBTK NA 95% Human Human -DTXSID0024555 Clint NA 7.774 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024555 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024555 Vd NA 1.813 L/kg 1compartment NA NA Rat Human -DTXSID0024555 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0024555 TK.Half.Life NA 8.655 hours 1compartment NA NA Rat Human -DTXSID0024555 Css NA 1.032 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024555 Css NA 4.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024555 Css NA 0.6647 mg/L PBTK NA 50% Rat Human -DTXSID0024555 Css NA 2.801 mg/L PBTK NA 95% Rat Human -DTXSID0024559 Clint NA 46.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024559 Fup NA 0.0747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024559 Vd NA 1.364 L/kg 1compartment NA NA Human Human +DTXSID0024553 Css NA 0.01428 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024553 Css NA 0.1043 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024553 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID0024553 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID0024559 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024559 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024559 Vd NA 1.606 L/kg 1compartment NA NA Human Human DTXSID0024559 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024559 TK.Half.Life NA 2.821 hours 1compartment NA NA Human Human -DTXSID0024559 Css NA 0.2007 mg/L 3compartmentss NA 50% Human Human -DTXSID0024559 Css NA 1.562 mg/L 3compartmentss NA 95% Human Human -DTXSID0024559 Css NA 0.1301 mg/L PBTK NA 50% Human Human -DTXSID0024559 Css NA 0.9633 mg/L PBTK NA 95% Human Human -DTXSID0024559 Clint NA 46.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024559 Fup NA 0.0747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024559 Vd NA 1.039 L/kg 1compartment NA NA Rat Human +DTXSID0024559 TK.Half.Life NA 8.498 hours 1compartment NA NA Human Human +DTXSID0024559 Css NA 0.7209 mg/L 3compartmentss NA 50% Human Human +DTXSID0024559 Css NA 6.02 mg/L 3compartmentss NA 95% Human Human +DTXSID0024559 Css NA 0.462 mg/L PBTK NA 50% Human Human +DTXSID0024559 Css NA 3.653 mg/L PBTK NA 95% Human Human +DTXSID0024559 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024559 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024559 Vd NA 1.203 L/kg 1compartment NA NA Rat Human DTXSID0024559 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024559 TK.Half.Life NA 1.097 hours 1compartment NA NA Rat Human -DTXSID0024559 Css NA 0.1152 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024559 Css NA 0.69 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024559 Css NA 0.06991 mg/L PBTK NA 50% Rat Human -DTXSID0024559 Css NA 0.4031 mg/L PBTK NA 95% Rat Human -DTXSID0024715 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024715 Fup NA 0.5552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024715 Vd NA 0.9132 L/kg 1compartment NA NA Human Human -DTXSID0024715 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0024715 TK.Half.Life NA 10.98 hours 1compartment NA NA Human Human -DTXSID0024715 Css NA 1.293 mg/L 3compartmentss NA 50% Human Human -DTXSID0024715 Css NA 9.066 mg/L 3compartmentss NA 95% Human Human -DTXSID0024715 Css NA 1.059 mg/L PBTK NA 50% Human Human -DTXSID0024715 Css NA 5.761 mg/L PBTK NA 95% Human Human -DTXSID0024715 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024715 Fup NA 0.5552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024715 Vd NA 0.8617 L/kg 1compartment NA NA Rat Human -DTXSID0024715 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024715 TK.Half.Life NA 3.447 hours 1compartment NA NA Rat Human -DTXSID0024715 Css NA 0.3453 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024715 Css NA 2.098 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024715 Css NA 0.2724 mg/L PBTK NA 50% Rat Human -DTXSID0024715 Css NA 1.247 mg/L PBTK NA 95% Rat Human -DTXSID0024761 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024761 Fup NA 0.3758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024761 Vd NA 1.395 L/kg 1compartment NA NA Human Human +DTXSID0024559 TK.Half.Life NA 3.175 hours 1compartment NA NA Rat Human +DTXSID0024559 Css NA 0.09246 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024559 Css NA 0.6222 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024559 Css NA 0.05802 mg/L PBTK NA 50% Rat Human +DTXSID0024559 Css NA 0.3726 mg/L PBTK NA 95% Rat Human +DTXSID0024761 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024761 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024761 Vd NA 1.16 L/kg 1compartment NA NA Human Human DTXSID0024761 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024761 TK.Half.Life NA 4.247 hours 1compartment NA NA Human Human -DTXSID0024761 Css NA 0.2798 mg/L 3compartmentss NA 50% Human Human -DTXSID0024761 Css NA 1.624 mg/L 3compartmentss NA 95% Human Human -DTXSID0024761 Css NA 0.2195 mg/L PBTK NA 50% Human Human -DTXSID0024761 Css NA 1.137 mg/L PBTK NA 95% Human Human -DTXSID0024761 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024761 Fup NA 0.3758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024761 Vd NA 1.161 L/kg 1compartment NA NA Rat Human +DTXSID0024761 TK.Half.Life NA 1.653 hours 1compartment NA NA Human Human +DTXSID0024761 Css NA 0.06784 mg/L 3compartmentss NA 50% Human Human +DTXSID0024761 Css NA 0.5229 mg/L 3compartmentss NA 95% Human Human +DTXSID0024761 Css NA 0.04977 mg/L PBTK NA 50% Human Human +DTXSID0024761 Css NA 0.3565 mg/L PBTK NA 95% Human Human +DTXSID0024761 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024761 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024761 Vd NA 0.9617 L/kg 1compartment NA NA Rat Human DTXSID0024761 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024761 TK.Half.Life NA 1.788 hours 1compartment NA NA Rat Human -DTXSID0024761 Css NA 0.1353 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024761 Css NA 0.5927 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024761 Css NA 0.1031 mg/L PBTK NA 50% Rat Human -DTXSID0024761 Css NA 0.3815 mg/L PBTK NA 95% Rat Human -DTXSID0024890 Clint NA 5.624 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024890 Fup NA 0.2242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024890 Vd NA 1.953 L/kg 1compartment NA NA Human Human +DTXSID0024761 TK.Half.Life NA 0.7053 hours 1compartment NA NA Rat Human +DTXSID0024761 Css NA 0.002418 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024761 Css NA 0.02047 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024761 Css NA 0.001725 mg/L PBTK NA 50% Rat Human +DTXSID0024761 Css NA 0.01344 mg/L PBTK NA 95% Rat Human +DTXSID0024890 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024890 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024890 Vd NA 1.601 L/kg 1compartment NA NA Human Human DTXSID0024890 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024890 TK.Half.Life NA 9.215 hours 1compartment NA NA Human Human -DTXSID0024890 Css NA 0.4898 mg/L 3compartmentss NA 50% Human Human -DTXSID0024890 Css NA 2.629 mg/L 3compartmentss NA 95% Human Human -DTXSID0024890 Css NA 0.3595 mg/L PBTK NA 50% Human Human -DTXSID0024890 Css NA 1.816 mg/L PBTK NA 95% Human Human -DTXSID0024890 Clint NA 5.624 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024890 Fup NA 0.2242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024890 Vd NA 1.521 L/kg 1compartment NA NA Rat Human +DTXSID0024890 TK.Half.Life NA 3.031 hours 1compartment NA NA Human Human +DTXSID0024890 Css NA 0.137 mg/L 3compartmentss NA 50% Human Human +DTXSID0024890 Css NA 0.9277 mg/L 3compartmentss NA 95% Human Human +DTXSID0024890 Css NA 0.0975 mg/L PBTK NA 50% Human Human +DTXSID0024890 Css NA 0.63 mg/L PBTK NA 95% Human Human +DTXSID0024890 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024890 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024890 Vd NA 1.258 L/kg 1compartment NA NA Rat Human DTXSID0024890 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024890 TK.Half.Life NA 3.125 hours 1compartment NA NA Rat Human -DTXSID0024890 Css NA 0.2509 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024890 Css NA 0.9604 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024890 Css NA 0.1771 mg/L PBTK NA 50% Rat Human -DTXSID0024890 Css NA 0.6224 mg/L PBTK NA 95% Rat Human -DTXSID0024896 Clint NA 5.043 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024896 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024896 Vd NA 0.2744 L/kg 1compartment NA NA Human Human -DTXSID0024896 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024896 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human -DTXSID0024896 Css NA 4.07 mg/L 3compartmentss NA 50% Human Human -DTXSID0024896 Css NA 31.11 mg/L 3compartmentss NA 95% Human Human -DTXSID0024896 Css NA 2.442 mg/L PBTK NA 50% Human Human -DTXSID0024896 Css NA 18.28 mg/L PBTK NA 95% Human Human -DTXSID0024896 Clint NA 5.043 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024896 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024896 Vd NA 0.268 L/kg 1compartment NA NA Rat Human +DTXSID0024890 TK.Half.Life NA 1.166 hours 1compartment NA NA Rat Human +DTXSID0024890 Css NA 0.01722 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024890 Css NA 0.08949 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024890 Css NA 0.01222 mg/L PBTK NA 50% Rat Human +DTXSID0024890 Css NA 0.06048 mg/L PBTK NA 95% Rat Human +DTXSID0024896 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024896 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024896 Vd NA 0.3808 L/kg 1compartment NA NA Human Human +DTXSID0024896 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0024896 TK.Half.Life NA 14.24 hours 1compartment NA NA Human Human +DTXSID0024896 Css NA 4.486 mg/L 3compartmentss NA 50% Human Human +DTXSID0024896 Css NA 15.92 mg/L 3compartmentss NA 95% Human Human +DTXSID0024896 Css NA 2.944 mg/L PBTK NA 50% Human Human +DTXSID0024896 Css NA 9.755 mg/L PBTK NA 95% Human Human +DTXSID0024896 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024896 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024896 Vd NA 0.3839 L/kg 1compartment NA NA Rat Human DTXSID0024896 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024896 TK.Half.Life NA 3.749 hours 1compartment NA NA Rat Human -DTXSID0024896 Css NA 2.121 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024896 Css NA 12.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024896 Css NA 1.202 mg/L PBTK NA 50% Rat Human -DTXSID0024896 Css NA 7.07 mg/L PBTK NA 95% Rat Human -DTXSID0024921 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024921 Fup NA 0.3291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024921 Vd NA 4.156 L/kg 1compartment NA NA Human Human -DTXSID0024921 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024921 TK.Half.Life NA 2.198 hours 1compartment NA NA Human Human -DTXSID0024921 Css NA 0.009867 mg/L 3compartmentss NA 50% Human Human -DTXSID0024921 Css NA 0.09463 mg/L 3compartmentss NA 95% Human Human -DTXSID0024921 Css NA 0.01352 mg/L PBTK NA 50% Human Human -DTXSID0024921 Css NA 0.09801 mg/L PBTK NA 95% Human Human -DTXSID0024921 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024921 Fup NA 0.3291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024921 Vd NA 4.207 L/kg 1compartment NA NA Rat Human -DTXSID0024921 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024921 TK.Half.Life NA 1.117 hours 1compartment NA NA Rat Human -DTXSID0024921 Css NA 0.005111 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024921 Css NA 0.04354 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024921 Css NA 0.007102 mg/L PBTK NA 50% Rat Human -DTXSID0024921 Css NA 0.04442 mg/L PBTK NA 95% Rat Human -DTXSID0024923 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024923 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024923 Vd NA 1.365 L/kg 1compartment NA NA Human Human -DTXSID0024923 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0024923 TK.Half.Life NA 8.842 hours 1compartment NA NA Human Human -DTXSID0024923 Css NA 0.7499 mg/L 3compartmentss NA 50% Human Human -DTXSID0024923 Css NA 5.477 mg/L 3compartmentss NA 95% Human Human -DTXSID0024923 Css NA 0.6937 mg/L PBTK NA 50% Human Human -DTXSID0024923 Css NA 3.755 mg/L PBTK NA 95% Human Human -DTXSID0024923 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024923 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024923 Vd NA 1.393 L/kg 1compartment NA NA Rat Human +DTXSID0024896 TK.Half.Life NA 4.892 hours 1compartment NA NA Rat Human +DTXSID0024896 Css NA 0.2914 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024896 Css NA 0.8583 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024896 Css NA 0.1876 mg/L PBTK NA 50% Rat Human +DTXSID0024896 Css NA 0.5071 mg/L PBTK NA 95% Rat Human +DTXSID0024921 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024921 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024921 Vd NA 3.021 L/kg 1compartment NA NA Human Human +DTXSID0024921 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID0024921 TK.Half.Life NA 48.14 hours 1compartment NA NA Human Human +DTXSID0024921 Css NA 1.097 mg/L 3compartmentss NA 50% Human Human +DTXSID0024921 Css NA 6.24 mg/L 3compartmentss NA 95% Human Human +DTXSID0024921 Css NA 1.286 mg/L PBTK NA 50% Human Human +DTXSID0024921 Css NA 4.891 mg/L PBTK NA 95% Human Human +DTXSID0024921 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024921 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024921 Vd NA 3.043 L/kg 1compartment NA NA Rat Human +DTXSID0024921 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0024921 TK.Half.Life NA 16.49 hours 1compartment NA NA Rat Human +DTXSID0024921 Css NA 0.06651 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024921 Css NA 0.3481 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024921 Css NA 0.08056 mg/L PBTK NA 50% Rat Human +DTXSID0024921 Css NA 0.2634 mg/L PBTK NA 95% Rat Human +DTXSID0024923 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024923 Fup 0.655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024923 Vd NA 1.037 L/kg 1compartment NA NA Human Human +DTXSID0024923 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0024923 TK.Half.Life NA 10.25 hours 1compartment NA NA Human Human +DTXSID0024923 Css NA 1.059 mg/L 3compartmentss NA 50% Human Human +DTXSID0024923 Css NA 7.096 mg/L 3compartmentss NA 95% Human Human +DTXSID0024923 Css NA 0.9004 mg/L PBTK NA 50% Human Human +DTXSID0024923 Css NA 4.617 mg/L PBTK NA 95% Human Human +DTXSID0024923 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024923 Fup 0.655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024923 Vd NA 1.055 L/kg 1compartment NA NA Rat Human DTXSID0024923 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024923 TK.Half.Life NA 3.072 hours 1compartment NA NA Rat Human -DTXSID0024923 Css NA 0.1872 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024923 Css NA 1.268 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024923 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0024923 Css NA 0.7895 mg/L PBTK NA 95% Rat Human -DTXSID0024977 Clint NA 0.02573 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024977 Fup NA 0.0239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024977 Vd NA 0.2496 L/kg 1compartment NA NA Human Human -DTXSID0024977 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID0024977 TK.Half.Life NA 64.78 hours 1compartment NA NA Human Human -DTXSID0024977 Css NA 43.54 mg/L 3compartmentss NA 50% Human Human -DTXSID0024977 Css NA 273.2 mg/L 3compartmentss NA 95% Human Human -DTXSID0024977 Css NA 25.99 mg/L PBTK NA 50% Human Human -DTXSID0024977 Css NA 161.2 mg/L PBTK NA 95% Human Human -DTXSID0024977 Clint NA 0.02573 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024977 Fup NA 0.0239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024977 Vd NA 0.2435 L/kg 1compartment NA NA Rat Human -DTXSID0024977 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0024977 TK.Half.Life NA 22.01 hours 1compartment NA NA Rat Human -DTXSID0024977 Css NA 12.69 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024977 Css NA 73.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024977 Css NA 7.08 mg/L PBTK NA 50% Rat Human -DTXSID0024977 Css NA 39.7 mg/L PBTK NA 95% Rat Human -DTXSID0024979 Clint NA 1.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024979 Fup NA 0.0328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0024979 Vd NA 0.2501 L/kg 1compartment NA NA Human Human -DTXSID0024979 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0024979 TK.Half.Life NA 15 hours 1compartment NA NA Human Human -DTXSID0024979 Css NA 10.6 mg/L 3compartmentss NA 50% Human Human -DTXSID0024979 Css NA 69.27 mg/L 3compartmentss NA 95% Human Human -DTXSID0024979 Css NA 6.368 mg/L PBTK NA 50% Human Human -DTXSID0024979 Css NA 40.24 mg/L PBTK NA 95% Human Human -DTXSID0024979 Clint NA 1.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024979 Fup NA 0.0328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0024979 Vd NA 0.2457 L/kg 1compartment NA NA Rat Human +DTXSID0024923 TK.Half.Life NA 3.551 hours 1compartment NA NA Rat Human +DTXSID0024923 Css NA 0.06366 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024923 Css NA 0.4121 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024923 Css NA 0.05411 mg/L PBTK NA 50% Rat Human +DTXSID0024923 Css NA 0.2559 mg/L PBTK NA 95% Rat Human +DTXSID0024977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024977 Fup 0.0527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024977 Vd NA 0.3347 L/kg 1compartment NA NA Human Human +DTXSID0024977 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0024977 TK.Half.Life NA 1.401 hours 1compartment NA NA Human Human +DTXSID0024977 Css NA 0.5772 mg/L 3compartmentss NA 50% Human Human +DTXSID0024977 Css NA 4.821 mg/L 3compartmentss NA 95% Human Human +DTXSID0024977 Css NA 0.359 mg/L PBTK NA 50% Human Human +DTXSID0024977 Css NA 2.868 mg/L PBTK NA 95% Human Human +DTXSID0024977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024977 Fup 0.0527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024977 Vd NA 0.3273 L/kg 1compartment NA NA Rat Human +DTXSID0024977 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0024977 TK.Half.Life NA 0.859 hours 1compartment NA NA Rat Human +DTXSID0024977 Css NA 0.07487 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024977 Css NA 0.5014 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024977 Css NA 0.0449 mg/L PBTK NA 50% Rat Human +DTXSID0024977 Css NA 0.2902 mg/L PBTK NA 95% Rat Human +DTXSID0024979 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024979 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0024979 Vd NA 0.5078 L/kg 1compartment NA NA Human Human +DTXSID0024979 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0024979 TK.Half.Life NA 19.55 hours 1compartment NA NA Human Human +DTXSID0024979 Css NA 4.329 mg/L 3compartmentss NA 50% Human Human +DTXSID0024979 Css NA 16.33 mg/L 3compartmentss NA 95% Human Human +DTXSID0024979 Css NA 3.03 mg/L PBTK NA 50% Human Human +DTXSID0024979 Css NA 10.15 mg/L PBTK NA 95% Human Human +DTXSID0024979 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024979 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0024979 Vd NA 0.504 L/kg 1compartment NA NA Rat Human DTXSID0024979 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0024979 TK.Half.Life NA 7.805 hours 1compartment NA NA Rat Human -DTXSID0024979 Css NA 4.746 mg/L 3compartmentss NA 50% Rat Human -DTXSID0024979 Css NA 25.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID0024979 Css NA 2.655 mg/L PBTK NA 50% Rat Human -DTXSID0024979 Css NA 13.67 mg/L PBTK NA 95% Rat Human -DTXSID0025070 Clint NA 1.629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025070 Fup NA 0.1108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025070 Vd NA 1.689 L/kg 1compartment NA NA Human Human -DTXSID0025070 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID0025070 TK.Half.Life NA 34.62 hours 1compartment NA NA Human Human -DTXSID0025070 Css NA 2.877 mg/L 3compartmentss NA 50% Human Human -DTXSID0025070 Css NA 14.73 mg/L 3compartmentss NA 95% Human Human -DTXSID0025070 Css NA 1.959 mg/L PBTK NA 50% Human Human -DTXSID0025070 Css NA 9.151 mg/L PBTK NA 95% Human Human -DTXSID0025070 Clint NA 1.629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025070 Fup NA 0.1108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025070 Vd NA 1.319 L/kg 1compartment NA NA Rat Human -DTXSID0025070 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0025070 TK.Half.Life NA 11.51 hours 1compartment NA NA Rat Human -DTXSID0025070 Css NA 1.29 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025070 Css NA 5.008 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025070 Css NA 0.8359 mg/L PBTK NA 50% Rat Human -DTXSID0025070 Css NA 2.899 mg/L PBTK NA 95% Rat Human -DTXSID0025074 Clint NA 1.338 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025074 Fup NA 0.144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025074 Vd NA 0.3625 L/kg 1compartment NA NA Human Human -DTXSID0025074 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025074 TK.Half.Life NA 5.196 hours 1compartment NA NA Human Human -DTXSID0025074 Css NA 2.025 mg/L 3compartmentss NA 50% Human Human -DTXSID0025074 Css NA 11.19 mg/L 3compartmentss NA 95% Human Human -DTXSID0025074 Css NA 1.305 mg/L PBTK NA 50% Human Human -DTXSID0025074 Css NA 6.641 mg/L PBTK NA 95% Human Human -DTXSID0025074 Clint NA 1.338 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025074 Fup NA 0.144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025074 Vd NA 0.3605 L/kg 1compartment NA NA Rat Human +DTXSID0024979 TK.Half.Life NA 6.614 hours 1compartment NA NA Rat Human +DTXSID0024979 Css NA 0.2817 mg/L 3compartmentss NA 50% Rat Human +DTXSID0024979 Css NA 0.8691 mg/L 3compartmentss NA 95% Rat Human +DTXSID0024979 Css NA 0.1929 mg/L PBTK NA 50% Rat Human +DTXSID0024979 Css NA 0.5261 mg/L PBTK NA 95% Rat Human +DTXSID0025070 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025070 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025070 Vd NA 1.361 L/kg 1compartment NA NA Human Human +DTXSID0025070 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0025070 TK.Half.Life NA 1.639 hours 1compartment NA NA Human Human +DTXSID0025070 Css NA 0.05798 mg/L 3compartmentss NA 50% Human Human +DTXSID0025070 Css NA 0.4522 mg/L 3compartmentss NA 95% Human Human +DTXSID0025070 Css NA 0.04528 mg/L PBTK NA 50% Human Human +DTXSID0025070 Css NA 0.311 mg/L PBTK NA 95% Human Human +DTXSID0025070 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025070 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025070 Vd NA 1.14 L/kg 1compartment NA NA Rat Human +DTXSID0025070 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0025070 TK.Half.Life NA 0.6809 hours 1compartment NA NA Rat Human +DTXSID0025070 Css NA 0.00727 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025070 Css NA 0.04137 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025070 Css NA 0.005694 mg/L PBTK NA 50% Rat Human +DTXSID0025070 Css NA 0.02915 mg/L PBTK NA 95% Rat Human +DTXSID0025074 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025074 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025074 Vd NA 0.5713 L/kg 1compartment NA NA Human Human +DTXSID0025074 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0025074 TK.Half.Life NA 10.59 hours 1compartment NA NA Human Human +DTXSID0025074 Css NA 1.071 mg/L 3compartmentss NA 50% Human Human +DTXSID0025074 Css NA 4.978 mg/L 3compartmentss NA 95% Human Human +DTXSID0025074 Css NA 0.8121 mg/L PBTK NA 50% Human Human +DTXSID0025074 Css NA 3.249 mg/L PBTK NA 95% Human Human +DTXSID0025074 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025074 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025074 Vd NA 0.5724 L/kg 1compartment NA NA Rat Human DTXSID0025074 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025074 TK.Half.Life NA 2.69 hours 1compartment NA NA Rat Human -DTXSID0025074 Css NA 0.8894 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025074 Css NA 3.906 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025074 Css NA 0.542 mg/L PBTK NA 50% Rat Human -DTXSID0025074 Css NA 2.185 mg/L PBTK NA 95% Rat Human -DTXSID0025076 Clint NA 1.484 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025076 Fup NA 0.0379 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025076 Vd NA 0.2266 L/kg 1compartment NA NA Human Human -DTXSID0025076 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0025076 TK.Half.Life NA 11.3 hours 1compartment NA NA Human Human -DTXSID0025076 Css NA 9.034 mg/L 3compartmentss NA 50% Human Human -DTXSID0025076 Css NA 57.89 mg/L 3compartmentss NA 95% Human Human -DTXSID0025076 Css NA 5.418 mg/L PBTK NA 50% Human Human -DTXSID0025076 Css NA 33.8 mg/L PBTK NA 95% Human Human -DTXSID0025076 Clint NA 1.484 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025076 Fup NA 0.0379 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025076 Vd NA 0.2219 L/kg 1compartment NA NA Rat Human +DTXSID0025074 TK.Half.Life NA 3.618 hours 1compartment NA NA Rat Human +DTXSID0025074 Css NA 0.005747 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025074 Css NA 0.02623 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025074 Css NA 0.004188 mg/L PBTK NA 50% Rat Human +DTXSID0025074 Css NA 0.01665 mg/L PBTK NA 95% Rat Human +DTXSID0025076 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025076 Fup 0.0503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025076 Vd NA 0.2508 L/kg 1compartment NA NA Human Human +DTXSID0025076 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0025076 TK.Half.Life NA 3.039 hours 1compartment NA NA Human Human +DTXSID0025076 Css NA 1.78 mg/L 3compartmentss NA 50% Human Human +DTXSID0025076 Css NA 12.62 mg/L 3compartmentss NA 95% Human Human +DTXSID0025076 Css NA 1.071 mg/L PBTK NA 50% Human Human +DTXSID0025076 Css NA 7.304 mg/L PBTK NA 95% Human Human +DTXSID0025076 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025076 Fup 0.0503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025076 Vd NA 0.245 L/kg 1compartment NA NA Rat Human DTXSID0025076 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025076 TK.Half.Life NA 5.919 hours 1compartment NA NA Rat Human -DTXSID0025076 Css NA 3.964 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025076 Css NA 20.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025076 Css NA 2.214 mg/L PBTK NA 50% Rat Human -DTXSID0025076 Css NA 11.07 mg/L PBTK NA 95% Rat Human -DTXSID0025078 Clint NA 0.6938 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025078 Fup NA 0.0756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025078 Vd NA 0.4344 L/kg 1compartment NA NA Human Human -DTXSID0025078 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0025078 TK.Half.Life NA 17.36 hours 1compartment NA NA Human Human -DTXSID0025078 Css NA 6.323 mg/L 3compartmentss NA 50% Human Human -DTXSID0025078 Css NA 32.13 mg/L 3compartmentss NA 95% Human Human -DTXSID0025078 Css NA 3.917 mg/L PBTK NA 50% Human Human -DTXSID0025078 Css NA 18.88 mg/L PBTK NA 95% Human Human -DTXSID0025078 Clint NA 0.6938 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025078 Fup NA 0.0756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025078 Vd NA 0.3791 L/kg 1compartment NA NA Rat Human +DTXSID0025076 TK.Half.Life NA 1.853 hours 1compartment NA NA Rat Human +DTXSID0025076 Css NA 0.07984 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025076 Css NA 0.676 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025076 Css NA 0.04624 mg/L PBTK NA 50% Rat Human +DTXSID0025076 Css NA 0.3821 mg/L PBTK NA 95% Rat Human +DTXSID0025078 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025078 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025078 Vd NA 0.9638 L/kg 1compartment NA NA Human Human +DTXSID0025078 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0025078 TK.Half.Life NA 1.269 hours 1compartment NA NA Human Human +DTXSID0025078 Css NA 0.06987 mg/L 3compartmentss NA 50% Human Human +DTXSID0025078 Css NA 0.5126 mg/L 3compartmentss NA 95% Human Human +DTXSID0025078 Css NA 0.0515 mg/L PBTK NA 50% Human Human +DTXSID0025078 Css NA 0.3543 mg/L PBTK NA 95% Human Human +DTXSID0025078 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025078 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025078 Vd NA 0.8304 L/kg 1compartment NA NA Rat Human DTXSID0025078 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025078 TK.Half.Life NA 7.054 hours 1compartment NA NA Rat Human -DTXSID0025078 Css NA 2.55 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025078 Css NA 10.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025078 Css NA 1.47 mg/L PBTK NA 50% Rat Human -DTXSID0025078 Css NA 5.568 mg/L PBTK NA 95% Rat Human +DTXSID0025078 TK.Half.Life NA 0.5682 hours 1compartment NA NA Rat Human +DTXSID0025078 Css NA 0.008683 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025078 Css NA 0.04938 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025078 Css NA 0.006358 mg/L PBTK NA 50% Rat Human +DTXSID0025078 Css NA 0.03276 mg/L PBTK NA 95% Rat Human DTXSID0025101 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0025101 Fup 0.242 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0025101 Vd NA 0.8537 L/kg 1compartment NA NA Human Human DTXSID0025101 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID0025101 TK.Half.Life NA 24.27 hours 1compartment NA NA Human Human -DTXSID0025101 Css NA 2.776 mg/L 3compartmentss NA 50% Human Human -DTXSID0025101 Css NA 12.41 mg/L 3compartmentss NA 95% Human Human -DTXSID0025101 Css NA 2.016 mg/L PBTK NA 50% Human Human -DTXSID0025101 Css NA 7.82 mg/L PBTK NA 95% Human Human +DTXSID0025101 Css NA 2.651 mg/L 3compartmentss NA 50% Human Human +DTXSID0025101 Css NA 11.79 mg/L 3compartmentss NA 95% Human Human +DTXSID0025101 Css NA 1.931 mg/L PBTK NA 50% Human Human +DTXSID0025101 Css NA 7.487 mg/L PBTK NA 95% Human Human DTXSID0025101 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0025101 Fup 0.242 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0025101 Vd NA 0.7367 L/kg 1compartment NA NA Rat Human DTXSID0025101 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0025101 TK.Half.Life NA 6.816 hours 1compartment NA NA Rat Human -DTXSID0025101 Css NA 0.797 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025101 Css NA 2.904 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025101 Css NA 0.5506 mg/L PBTK NA 50% Rat Human -DTXSID0025101 Css NA 1.712 mg/L PBTK NA 95% Rat Human +DTXSID0025101 Css NA 0.1794 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025101 Css NA 0.6778 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025101 Css NA 0.1286 mg/L PBTK NA 50% Rat Human +DTXSID0025101 Css NA 0.4129 mg/L PBTK NA 95% Rat Human DTXSID0025234 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0025234 Fup 0.0524 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0025234 Vd NA 0.6255 L/kg 1compartment NA NA Human Human -DTXSID0025234 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID0025234 TK.Half.Life NA 78.14 hours 1compartment NA NA Human Human -DTXSID0025234 Css NA 14.02 mg/L 3compartmentss NA 50% Human Human -DTXSID0025234 Css NA 55.42 mg/L 3compartmentss NA 95% Human Human -DTXSID0025234 Css NA 9.785 mg/L PBTK NA 50% Human Human -DTXSID0025234 Css NA 34.75 mg/L PBTK NA 95% Human Human +DTXSID0025234 Vd NA 2.478 L/kg 1compartment NA NA Human Human +DTXSID0025234 Days.Css NA 100 Days PBTK NA NA Human Human +DTXSID0025234 TK.Half.Life NA 422.9 hours 1compartment NA NA Human Human +DTXSID0025234 Css NA 14.58 mg/L 3compartmentss NA 50% Human Human +DTXSID0025234 Css NA 58.54 mg/L 3compartmentss NA 95% Human Human +DTXSID0025234 Css NA 13.18 mg/L PBTK NA 50% Human Human +DTXSID0025234 Css NA 42.19 mg/L PBTK NA 95% Human Human DTXSID0025234 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0025234 Fup 0.0524 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0025234 Vd NA 0.5921 L/kg 1compartment NA NA Rat Human -DTXSID0025234 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0025234 TK.Half.Life NA 24.98 hours 1compartment NA NA Rat Human -DTXSID0025234 Css NA 3.877 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025234 Css NA 12.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025234 Css NA 2.576 mg/L PBTK NA 50% Rat Human -DTXSID0025234 Css NA 7.295 mg/L PBTK NA 95% Rat Human -DTXSID0025361 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025361 Fup NA 0.8203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025361 Vd NA 1.105 L/kg 1compartment NA NA Human Human +DTXSID0025234 Vd NA 2.015 L/kg 1compartment NA NA Rat Human +DTXSID0025234 Days.Css NA 25 Days PBTK NA NA Rat Human +DTXSID0025234 TK.Half.Life NA 92.49 hours 1compartment NA NA Rat Human +DTXSID0025234 Css NA 0.91 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025234 Css NA 3.084 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025234 Css NA 0.832 mg/L PBTK NA 50% Rat Human +DTXSID0025234 Css NA 2.147 mg/L PBTK NA 95% Rat Human +DTXSID0025315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025315 Fup 0.0874 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025315 Vd NA 3.027 L/kg 1compartment NA NA Human Human +DTXSID0025315 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0025315 TK.Half.Life NA 34.25 hours 1compartment NA NA Human Human +DTXSID0025315 Css NA 1.3 mg/L 3compartmentss NA 50% Human Human +DTXSID0025315 Css NA 8.323 mg/L 3compartmentss NA 95% Human Human +DTXSID0025315 Css NA 0.9068 mg/L PBTK NA 50% Human Human +DTXSID0025315 Css NA 5.642 mg/L PBTK NA 95% Human Human +DTXSID0025315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025315 Fup 0.0874 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025315 Vd NA 2.275 L/kg 1compartment NA NA Rat Human +DTXSID0025315 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0025315 TK.Half.Life NA 5.572 hours 1compartment NA NA Rat Human +DTXSID0025315 Css NA 0.1672 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025315 Css NA 0.9683 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025315 Css NA 0.1157 mg/L PBTK NA 50% Rat Human +DTXSID0025315 Css NA 0.6565 mg/L PBTK NA 95% Rat Human +DTXSID0025361 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025361 Fup 0.7 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025361 Vd NA 1.085 L/kg 1compartment NA NA Human Human DTXSID0025361 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025361 TK.Half.Life NA 9.045 hours 1compartment NA NA Human Human -DTXSID0025361 Css NA 0.9223 mg/L 3compartmentss NA 50% Human Human -DTXSID0025361 Css NA 5.937 mg/L 3compartmentss NA 95% Human Human -DTXSID0025361 Css NA 0.8216 mg/L PBTK NA 50% Human Human -DTXSID0025361 Css NA 3.986 mg/L PBTK NA 95% Human Human -DTXSID0025361 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025361 Fup NA 0.8203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025361 Vd NA 1.057 L/kg 1compartment NA NA Rat Human +DTXSID0025361 TK.Half.Life NA 0.8832 hours 1compartment NA NA Human Human +DTXSID0025361 Css NA 0.02844 mg/L 3compartmentss NA 50% Human Human +DTXSID0025361 Css NA 0.3053 mg/L 3compartmentss NA 95% Human Human +DTXSID0025361 Css NA 0.02423 mg/L PBTK NA 50% Human Human +DTXSID0025361 Css NA 0.2197 mg/L PBTK NA 95% Human Human +DTXSID0025361 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025361 Fup 0.7 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025361 Vd NA 1.019 L/kg 1compartment NA NA Rat Human DTXSID0025361 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025361 TK.Half.Life NA 2.867 hours 1compartment NA NA Rat Human -DTXSID0025361 Css NA 0.2354 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025361 Css NA 1.461 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025361 Css NA 0.2037 mg/L PBTK NA 50% Rat Human -DTXSID0025361 Css NA 0.8967 mg/L PBTK NA 95% Rat Human +DTXSID0025361 TK.Half.Life NA 0.4044 hours 1compartment NA NA Rat Human +DTXSID0025361 Css NA 0.003305 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025361 Css NA 0.03146 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025361 Css NA 0.002891 mg/L PBTK NA 50% Rat Human +DTXSID0025361 Css NA 0.02204 mg/L PBTK NA 95% Rat Human DTXSID0025363 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0025363 Fup NA 0.4077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0025363 Vd NA 0.37 L/kg 1compartment NA NA Human Human DTXSID0025363 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0025363 TK.Half.Life NA 5.869 hours 1compartment NA NA Human Human -DTXSID0025363 Css NA 1.908 mg/L 3compartmentss NA 50% Human Human -DTXSID0025363 Css NA 7.917 mg/L 3compartmentss NA 95% Human Human -DTXSID0025363 Css NA 1.323 mg/L PBTK NA 50% Human Human -DTXSID0025363 Css NA 4.917 mg/L PBTK NA 95% Human Human +DTXSID0025363 Css NA 1.594 mg/L 3compartmentss NA 50% Human Human +DTXSID0025363 Css NA 7.056 mg/L 3compartmentss NA 95% Human Human +DTXSID0025363 Css NA 1.113 mg/L PBTK NA 50% Human Human +DTXSID0025363 Css NA 4.383 mg/L PBTK NA 95% Human Human DTXSID0025363 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0025363 Fup NA 0.4077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0025363 Vd NA 0.3872 L/kg 1compartment NA NA Rat Human DTXSID0025363 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0025363 TK.Half.Life NA 2.093 hours 1compartment NA NA Rat Human -DTXSID0025363 Css NA 0.5236 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025363 Css NA 1.907 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025363 Css NA 0.345 mg/L PBTK NA 50% Rat Human -DTXSID0025363 Css NA 1.101 mg/L PBTK NA 95% Rat Human +DTXSID0025363 Css NA 0.02922 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025363 Css NA 0.1844 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025363 Css NA 0.0195 mg/L PBTK NA 50% Rat Human +DTXSID0025363 Css NA 0.114 mg/L PBTK NA 95% Rat Human DTXSID0025367 Clint NA 0.1907 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0025367 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0025367 Vd NA 0.6807 L/kg 1compartment NA NA Human Human DTXSID0025367 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0025367 TK.Half.Life NA 3.363 hours 1compartment NA NA Human Human -DTXSID0025367 Css NA 0.6378 mg/L 3compartmentss NA 50% Human Human -DTXSID0025367 Css NA 4.088 mg/L 3compartmentss NA 95% Human Human -DTXSID0025367 Css NA 0.5175 mg/L PBTK NA 50% Human Human -DTXSID0025367 Css NA 2.611 mg/L PBTK NA 95% Human Human +DTXSID0025367 Css NA 0.5398 mg/L 3compartmentss NA 50% Human Human +DTXSID0025367 Css NA 3.385 mg/L 3compartmentss NA 95% Human Human +DTXSID0025367 Css NA 0.4358 mg/L PBTK NA 50% Human Human +DTXSID0025367 Css NA 2.21 mg/L PBTK NA 95% Human Human DTXSID0025367 Clint NA 0.1907 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0025367 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0025367 Vd NA 0.7209 L/kg 1compartment NA NA Rat Human DTXSID0025367 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0025367 TK.Half.Life NA 1.38 hours 1compartment NA NA Rat Human -DTXSID0025367 Css NA 0.1884 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025367 Css NA 1.16 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025367 Css NA 0.1493 mg/L PBTK NA 50% Rat Human -DTXSID0025367 Css NA 0.6924 mg/L PBTK NA 95% Rat Human -DTXSID0025440 Clint NA 22.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025440 Fup NA 0.9164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025440 Vd NA 1.642 L/kg 1compartment NA NA Human Human -DTXSID0025440 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025440 TK.Half.Life NA 1.044 hours 1compartment NA NA Human Human -DTXSID0025440 Css NA 0.02038 mg/L 3compartmentss NA 50% Human Human -DTXSID0025440 Css NA 0.1496 mg/L 3compartmentss NA 95% Human Human -DTXSID0025440 Css NA 0.01954 mg/L PBTK NA 50% Human Human -DTXSID0025440 Css NA 0.1271 mg/L PBTK NA 95% Human Human -DTXSID0025440 Clint NA 22.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025440 Fup NA 0.9164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025440 Vd NA 1.645 L/kg 1compartment NA NA Rat Human +DTXSID0025367 Css NA 0.01136 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025367 Css NA 0.09571 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025367 Css NA 0.009032 mg/L PBTK NA 50% Rat Human +DTXSID0025367 Css NA 0.06035 mg/L PBTK NA 95% Rat Human +DTXSID0025440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025440 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025440 Vd NA 0.828 L/kg 1compartment NA NA Human Human +DTXSID0025440 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0025440 TK.Half.Life NA 13.36 hours 1compartment NA NA Human Human +DTXSID0025440 Css NA 1.666 mg/L 3compartmentss NA 50% Human Human +DTXSID0025440 Css NA 7.661 mg/L 3compartmentss NA 95% Human Human +DTXSID0025440 Css NA 1.293 mg/L PBTK NA 50% Human Human +DTXSID0025440 Css NA 5.033 mg/L PBTK NA 95% Human Human +DTXSID0025440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025440 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025440 Vd NA 0.8286 L/kg 1compartment NA NA Rat Human DTXSID0025440 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025440 TK.Half.Life NA 0.51 hours 1compartment NA NA Rat Human -DTXSID0025440 Css NA 0.01031 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025440 Css NA 0.0642 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025440 Css NA 0.009983 mg/L PBTK NA 50% Rat Human -DTXSID0025440 Css NA 0.05435 mg/L PBTK NA 95% Rat Human -DTXSID0025494 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025494 Fup NA 0.04 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025494 Vd NA 3.049 L/kg 1compartment NA NA Human Human -DTXSID0025494 Days.Css NA 2930 Days PBTK NA NA Human Human -DTXSID0025494 TK.Half.Life NA 10690 hours 1compartment NA NA Human Human -DTXSID0025494 Css NA 412.8 mg/L 3compartmentss NA 50% Human Human -DTXSID0025494 Css NA 1157 mg/L 3compartmentss NA 95% Human Human -DTXSID0025494 Css NA 286.2 mg/L PBTK NA 50% Human Human -DTXSID0025494 Css NA 753.2 mg/L PBTK NA 95% Human Human -DTXSID0025494 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025494 Fup NA 0.04 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025494 Vd NA 2.285 L/kg 1compartment NA NA Rat Human -DTXSID0025494 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID0025494 TK.Half.Life NA 746.8 hours 1compartment NA NA Rat Human -DTXSID0025494 Css NA 112.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025494 Css NA 255.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025494 Css NA 74.37 mg/L PBTK NA 50% Rat Human -DTXSID0025494 Css NA 153 mg/L PBTK NA 95% Rat Human -DTXSID0025523 Clint NA 1.432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025523 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025523 Vd NA 0.934 L/kg 1compartment NA NA Human Human +DTXSID0025440 TK.Half.Life NA 4.554 hours 1compartment NA NA Rat Human +DTXSID0025440 Css NA 0.1055 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025440 Css NA 0.4223 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025440 Css NA 0.08158 mg/L PBTK NA 50% Rat Human +DTXSID0025440 Css NA 0.2641 mg/L PBTK NA 95% Rat Human +DTXSID0025494 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025494 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025494 Vd NA 3.103 L/kg 1compartment NA NA Human Human +DTXSID0025494 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID0025494 TK.Half.Life NA 81.04 hours 1compartment NA NA Human Human +DTXSID0025494 Css NA 3.104 mg/L 3compartmentss NA 50% Human Human +DTXSID0025494 Css NA 20.2 mg/L 3compartmentss NA 95% Human Human +DTXSID0025494 Css NA 2.149 mg/L PBTK NA 50% Human Human +DTXSID0025494 Css NA 13.45 mg/L PBTK NA 95% Human Human +DTXSID0025494 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025494 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025494 Vd NA 2.324 L/kg 1compartment NA NA Rat Human +DTXSID0025494 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID0025494 TK.Half.Life NA 11.23 hours 1compartment NA NA Rat Human +DTXSID0025494 Css NA 0.4034 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025494 Css NA 2.175 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025494 Css NA 0.2761 mg/L PBTK NA 50% Rat Human +DTXSID0025494 Css NA 1.444 mg/L PBTK NA 95% Rat Human +DTXSID0025523 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025523 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025523 Vd NA 0.6541 L/kg 1compartment NA NA Human Human DTXSID0025523 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025523 TK.Half.Life NA 2.06 hours 1compartment NA NA Human Human -DTXSID0025523 Css NA 0.246 mg/L 3compartmentss NA 50% Human Human -DTXSID0025523 Css NA 1.741 mg/L 3compartmentss NA 95% Human Human -DTXSID0025523 Css NA 0.2124 mg/L PBTK NA 50% Human Human -DTXSID0025523 Css NA 1.211 mg/L PBTK NA 95% Human Human -DTXSID0025523 Clint NA 1.432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025523 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025523 Vd NA 0.9427 L/kg 1compartment NA NA Rat Human +DTXSID0025523 TK.Half.Life NA 0.643 hours 1compartment NA NA Human Human +DTXSID0025523 Css NA 0.0376 mg/L 3compartmentss NA 50% Human Human +DTXSID0025523 Css NA 0.3404 mg/L 3compartmentss NA 95% Human Human +DTXSID0025523 Css NA 0.02889 mg/L PBTK NA 50% Human Human +DTXSID0025523 Css NA 0.2337 mg/L PBTK NA 95% Human Human +DTXSID0025523 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025523 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025523 Vd NA 0.6575 L/kg 1compartment NA NA Rat Human DTXSID0025523 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025523 TK.Half.Life NA 1.033 hours 1compartment NA NA Rat Human -DTXSID0025523 Css NA 0.09535 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025523 Css NA 0.6347 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025523 Css NA 0.08203 mg/L PBTK NA 50% Rat Human -DTXSID0025523 Css NA 0.3931 mg/L PBTK NA 95% Rat Human -DTXSID0025527 Clint NA 71.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025527 Fup NA 0.0602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025527 Vd NA 2.023 L/kg 1compartment NA NA Human Human +DTXSID0025523 TK.Half.Life NA 0.3247 hours 1compartment NA NA Rat Human +DTXSID0025523 Css NA 0.004655 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025523 Css NA 0.03526 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025523 Css NA 0.003606 mg/L PBTK NA 50% Rat Human +DTXSID0025523 Css NA 0.02343 mg/L PBTK NA 95% Rat Human +DTXSID0025527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025527 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025527 Vd NA 2.532 L/kg 1compartment NA NA Human Human DTXSID0025527 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025527 TK.Half.Life NA 4.178 hours 1compartment NA NA Human Human -DTXSID0025527 Css NA 0.1921 mg/L 3compartmentss NA 50% Human Human -DTXSID0025527 Css NA 1.447 mg/L 3compartmentss NA 95% Human Human -DTXSID0025527 Css NA 0.1269 mg/L PBTK NA 50% Human Human -DTXSID0025527 Css NA 0.9148 mg/L PBTK NA 95% Human Human -DTXSID0025527 Clint NA 71.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025527 Fup NA 0.0602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025527 Vd NA 1.52 L/kg 1compartment NA NA Rat Human +DTXSID0025527 TK.Half.Life NA 13.69 hours 1compartment NA NA Human Human +DTXSID0025527 Css NA 0.6354 mg/L 3compartmentss NA 50% Human Human +DTXSID0025527 Css NA 4.074 mg/L 3compartmentss NA 95% Human Human +DTXSID0025527 Css NA 0.4326 mg/L PBTK NA 50% Human Human +DTXSID0025527 Css NA 2.689 mg/L PBTK NA 95% Human Human +DTXSID0025527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025527 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025527 Vd NA 1.904 L/kg 1compartment NA NA Rat Human DTXSID0025527 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025527 TK.Half.Life NA 1.371 hours 1compartment NA NA Rat Human -DTXSID0025527 Css NA 0.1078 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025527 Css NA 0.6175 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025527 Css NA 0.06759 mg/L PBTK NA 50% Rat Human -DTXSID0025527 Css NA 0.3754 mg/L PBTK NA 95% Rat Human -DTXSID0025571 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025571 Fup NA 0.7318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025571 Vd NA 1.111 L/kg 1compartment NA NA Human Human +DTXSID0025527 TK.Half.Life NA 3.473 hours 1compartment NA NA Rat Human +DTXSID0025527 Css NA 0.08159 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025527 Css NA 0.4224 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025527 Css NA 0.05494 mg/L PBTK NA 50% Rat Human +DTXSID0025527 Css NA 0.2751 mg/L PBTK NA 95% Rat Human +DTXSID0025571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025571 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025571 Vd NA 0.6575 L/kg 1compartment NA NA Human Human DTXSID0025571 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025571 TK.Half.Life NA 1.648 hours 1compartment NA NA Human Human -DTXSID0025571 Css NA 0.1199 mg/L 3compartmentss NA 50% Human Human -DTXSID0025571 Css NA 0.972 mg/L 3compartmentss NA 95% Human Human -DTXSID0025571 Css NA 0.1036 mg/L PBTK NA 50% Human Human -DTXSID0025571 Css NA 0.6762 mg/L PBTK NA 95% Human Human -DTXSID0025571 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025571 Fup NA 0.7318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025571 Vd NA 1.043 L/kg 1compartment NA NA Rat Human +DTXSID0025571 TK.Half.Life NA 0.657 hours 1compartment NA NA Human Human +DTXSID0025571 Css NA 0.03809 mg/L 3compartmentss NA 50% Human Human +DTXSID0025571 Css NA 0.3563 mg/L 3compartmentss NA 95% Human Human +DTXSID0025571 Css NA 0.02942 mg/L PBTK NA 50% Human Human +DTXSID0025571 Css NA 0.2399 mg/L PBTK NA 95% Human Human +DTXSID0025571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025571 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025571 Vd NA 0.6572 L/kg 1compartment NA NA Rat Human DTXSID0025571 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025571 TK.Half.Life NA 0.8141 hours 1compartment NA NA Rat Human -DTXSID0025571 Css NA 0.05593 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025571 Css NA 0.4152 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025571 Css NA 0.04776 mg/L PBTK NA 50% Rat Human -DTXSID0025571 Css NA 0.2579 mg/L PBTK NA 95% Rat Human -DTXSID0025577 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025577 Fup NA 0.9423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025577 Vd NA 0.9366 L/kg 1compartment NA NA Human Human -DTXSID0025577 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025577 TK.Half.Life NA 6.484 hours 1compartment NA NA Human Human -DTXSID0025577 Css NA 0.8622 mg/L 3compartmentss NA 50% Human Human -DTXSID0025577 Css NA 5.122 mg/L 3compartmentss NA 95% Human Human -DTXSID0025577 Css NA 0.7492 mg/L PBTK NA 50% Human Human -DTXSID0025577 Css NA 3.388 mg/L PBTK NA 95% Human Human -DTXSID0025577 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025577 Fup NA 0.9423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025577 Vd NA 0.9439 L/kg 1compartment NA NA Rat Human -DTXSID0025577 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025577 TK.Half.Life NA 2.213 hours 1compartment NA NA Rat Human -DTXSID0025577 Css NA 0.2199 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025577 Css NA 1.223 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025577 Css NA 0.1863 mg/L PBTK NA 50% Rat Human -DTXSID0025577 Css NA 0.7537 mg/L PBTK NA 95% Rat Human -DTXSID0025600 Clint NA 3.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025600 Fup NA 0.7883 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025600 Vd NA 3.126 L/kg 1compartment NA NA Human Human -DTXSID0025600 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID0025600 TK.Half.Life NA 70.33 hours 1compartment NA NA Human Human -DTXSID0025600 Css NA 2.566 mg/L 3compartmentss NA 50% Human Human -DTXSID0025600 Css NA 12.73 mg/L 3compartmentss NA 95% Human Human -DTXSID0025600 Css NA 1.872 mg/L PBTK NA 50% Human Human -DTXSID0025600 Css NA 8.737 mg/L PBTK NA 95% Human Human -DTXSID0025600 Clint NA 3.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025600 Fup NA 0.7883 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025600 Vd NA 2.364 L/kg 1compartment NA NA Rat Human -DTXSID0025600 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID0025600 TK.Half.Life NA 9.294 hours 1compartment NA NA Rat Human -DTXSID0025600 Css NA 1.316 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025600 Css NA 4.526 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025600 Css NA 0.9206 mg/L PBTK NA 50% Rat Human -DTXSID0025600 Css NA 3.034 mg/L PBTK NA 95% Rat Human -DTXSID0025654 Clint NA 28.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025654 Fup NA 0.0276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025654 Vd NA 3.106 L/kg 1compartment NA NA Human Human -DTXSID0025654 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID0025654 TK.Half.Life NA 61.29 hours 1compartment NA NA Human Human -DTXSID0025654 Css NA 2.368 mg/L 3compartmentss NA 50% Human Human -DTXSID0025654 Css NA 15.77 mg/L 3compartmentss NA 95% Human Human -DTXSID0025654 Css NA 1.648 mg/L PBTK NA 50% Human Human -DTXSID0025654 Css NA 10.35 mg/L PBTK NA 95% Human Human -DTXSID0025654 Clint NA 28.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025654 Fup NA 0.0276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025654 Vd NA 2.326 L/kg 1compartment NA NA Rat Human -DTXSID0025654 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID0025654 TK.Half.Life NA 8.571 hours 1compartment NA NA Rat Human -DTXSID0025654 Css NA 1.328 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025654 Css NA 7.246 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025654 Css NA 0.8842 mg/L PBTK NA 50% Rat Human -DTXSID0025654 Css NA 4.553 mg/L PBTK NA 95% Rat Human -DTXSID0025733 Clint NA 0.4454 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025733 Fup NA 0.7521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025733 Vd NA 0.7728 L/kg 1compartment NA NA Human Human +DTXSID0025571 TK.Half.Life NA 0.3309 hours 1compartment NA NA Rat Human +DTXSID0025571 Css NA 0.004768 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025571 Css NA 0.03399 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025571 Css NA 0.003686 mg/L PBTK NA 50% Rat Human +DTXSID0025571 Css NA 0.02269 mg/L PBTK NA 95% Rat Human +DTXSID0025600 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025600 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025600 Vd NA 2.805 L/kg 1compartment NA NA Human Human +DTXSID0025600 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0025600 TK.Half.Life NA 8.731 hours 1compartment NA NA Human Human +DTXSID0025600 Css NA 0.2403 mg/L 3compartmentss NA 50% Human Human +DTXSID0025600 Css NA 1.488 mg/L 3compartmentss NA 95% Human Human +DTXSID0025600 Css NA 0.1749 mg/L PBTK NA 50% Human Human +DTXSID0025600 Css NA 1.04 mg/L PBTK NA 95% Human Human +DTXSID0025600 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025600 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025600 Vd NA 2.13 L/kg 1compartment NA NA Rat Human +DTXSID0025600 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0025600 TK.Half.Life NA 2.016 hours 1compartment NA NA Rat Human +DTXSID0025600 Css NA 0.01175 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025600 Css NA 0.07712 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025600 Css NA 0.00849 mg/L PBTK NA 50% Rat Human +DTXSID0025600 Css NA 0.05276 mg/L PBTK NA 95% Rat Human +DTXSID0025654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025654 Fup 0.00954 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025654 Vd NA 3.003 L/kg 1compartment NA NA Human Human +DTXSID0025654 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID0025654 TK.Half.Life NA 75.2 hours 1compartment NA NA Human Human +DTXSID0025654 Css NA 3.129 mg/L 3compartmentss NA 50% Human Human +DTXSID0025654 Css NA 20.34 mg/L 3compartmentss NA 95% Human Human +DTXSID0025654 Css NA 2.134 mg/L PBTK NA 50% Human Human +DTXSID0025654 Css NA 13.74 mg/L PBTK NA 95% Human Human +DTXSID0025654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025654 Fup 0.00954 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025654 Vd NA 2.247 L/kg 1compartment NA NA Rat Human +DTXSID0025654 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID0025654 TK.Half.Life NA 11.8 hours 1compartment NA NA Rat Human +DTXSID0025654 Css NA 0.4066 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025654 Css NA 2.394 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025654 Css NA 0.2747 mg/L PBTK NA 50% Rat Human +DTXSID0025654 Css NA 1.561 mg/L PBTK NA 95% Rat Human +DTXSID0025733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025733 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025733 Vd NA 0.5562 L/kg 1compartment NA NA Human Human DTXSID0025733 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025733 TK.Half.Life NA 3.929 hours 1compartment NA NA Human Human -DTXSID0025733 Css NA 0.59 mg/L 3compartmentss NA 50% Human Human -DTXSID0025733 Css NA 3.683 mg/L 3compartmentss NA 95% Human Human -DTXSID0025733 Css NA 0.4859 mg/L PBTK NA 50% Human Human -DTXSID0025733 Css NA 2.391 mg/L PBTK NA 95% Human Human -DTXSID0025733 Clint NA 0.4454 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025733 Fup NA 0.7521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025733 Vd NA 0.7857 L/kg 1compartment NA NA Rat Human +DTXSID0025733 TK.Half.Life NA 0.6123 hours 1compartment NA NA Human Human +DTXSID0025733 Css NA 0.04673 mg/L 3compartmentss NA 50% Human Human +DTXSID0025733 Css NA 0.3816 mg/L 3compartmentss NA 95% Human Human +DTXSID0025733 Css NA 0.034 mg/L PBTK NA 50% Human Human +DTXSID0025733 Css NA 0.259 mg/L PBTK NA 95% Human Human +DTXSID0025733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025733 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025733 Vd NA 0.5634 L/kg 1compartment NA NA Rat Human DTXSID0025733 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025733 TK.Half.Life NA 1.713 hours 1compartment NA NA Rat Human -DTXSID0025733 Css NA 0.1936 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025733 Css NA 1.257 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025733 Css NA 0.1556 mg/L PBTK NA 50% Rat Human -DTXSID0025733 Css NA 0.7523 mg/L PBTK NA 95% Rat Human -DTXSID0025737 Clint NA 0.352 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025737 Fup NA 0.1581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025737 Vd NA 0.4111 L/kg 1compartment NA NA Human Human -DTXSID0025737 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0025737 TK.Half.Life NA 10.66 hours 1compartment NA NA Human Human -DTXSID0025737 Css NA 3.375 mg/L 3compartmentss NA 50% Human Human -DTXSID0025737 Css NA 15.41 mg/L 3compartmentss NA 95% Human Human -DTXSID0025737 Css NA 2.242 mg/L PBTK NA 50% Human Human -DTXSID0025737 Css NA 9.204 mg/L PBTK NA 95% Human Human -DTXSID0025737 Clint NA 0.352 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025737 Fup NA 0.1581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025737 Vd NA 0.4086 L/kg 1compartment NA NA Rat Human +DTXSID0025733 TK.Half.Life NA 0.3169 hours 1compartment NA NA Rat Human +DTXSID0025733 Css NA 0.00574 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025733 Css NA 0.03678 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025733 Css NA 0.004213 mg/L PBTK NA 50% Rat Human +DTXSID0025733 Css NA 0.02428 mg/L PBTK NA 95% Rat Human +DTXSID0025737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025737 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025737 Vd NA 0.468 L/kg 1compartment NA NA Human Human +DTXSID0025737 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0025737 TK.Half.Life NA 0.7553 hours 1compartment NA NA Human Human +DTXSID0025737 Css NA 0.1026 mg/L 3compartmentss NA 50% Human Human +DTXSID0025737 Css NA 0.734 mg/L 3compartmentss NA 95% Human Human +DTXSID0025737 Css NA 0.07114 mg/L PBTK NA 50% Human Human +DTXSID0025737 Css NA 0.4831 mg/L PBTK NA 95% Human Human +DTXSID0025737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025737 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025737 Vd NA 0.466 L/kg 1compartment NA NA Rat Human DTXSID0025737 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025737 TK.Half.Life NA 4.446 hours 1compartment NA NA Rat Human -DTXSID0025737 Css NA 1.197 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025737 Css NA 4.631 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025737 Css NA 0.7486 mg/L PBTK NA 50% Rat Human -DTXSID0025737 Css NA 2.623 mg/L PBTK NA 95% Rat Human -DTXSID0025789 Clint NA 2.625 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025789 Fup NA 0.3849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025789 Vd NA 1.681 L/kg 1compartment NA NA Human Human +DTXSID0025737 TK.Half.Life NA 0.4181 hours 1compartment NA NA Rat Human +DTXSID0025737 Css NA 0.01301 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025737 Css NA 0.07027 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025737 Css NA 0.008882 mg/L PBTK NA 50% Rat Human +DTXSID0025737 Css NA 0.04493 mg/L PBTK NA 95% Rat Human +DTXSID0025789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025789 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025789 Vd NA 1.086 L/kg 1compartment NA NA Human Human DTXSID0025789 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025789 TK.Half.Life NA 7.512 hours 1compartment NA NA Human Human -DTXSID0025789 Css NA 0.4392 mg/L 3compartmentss NA 50% Human Human -DTXSID0025789 Css NA 2.299 mg/L 3compartmentss NA 95% Human Human -DTXSID0025789 Css NA 0.3508 mg/L PBTK NA 50% Human Human -DTXSID0025789 Css NA 1.604 mg/L PBTK NA 95% Human Human -DTXSID0025789 Clint NA 2.625 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025789 Fup NA 0.3849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025789 Vd NA 1.365 L/kg 1compartment NA NA Rat Human +DTXSID0025789 TK.Half.Life NA 2.095 hours 1compartment NA NA Human Human +DTXSID0025789 Css NA 0.1545 mg/L 3compartmentss NA 50% Human Human +DTXSID0025789 Css NA 1.148 mg/L 3compartmentss NA 95% Human Human +DTXSID0025789 Css NA 0.1052 mg/L PBTK NA 50% Human Human +DTXSID0025789 Css NA 0.7366 mg/L PBTK NA 95% Human Human +DTXSID0025789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025789 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025789 Vd NA 0.8731 L/kg 1compartment NA NA Rat Human DTXSID0025789 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025789 TK.Half.Life NA 2.778 hours 1compartment NA NA Rat Human -DTXSID0025789 Css NA 0.2048 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025789 Css NA 0.7905 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025789 Css NA 0.1568 mg/L PBTK NA 50% Rat Human -DTXSID0025789 Css NA 0.5109 mg/L PBTK NA 95% Rat Human -DTXSID0025812 Clint NA 48.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025812 Fup NA 0.1089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025812 Vd NA 2.25 L/kg 1compartment NA NA Human Human +DTXSID0025789 TK.Half.Life NA 0.9003 hours 1compartment NA NA Rat Human +DTXSID0025789 Css NA 0.01963 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025789 Css NA 0.1165 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025789 Css NA 0.01316 mg/L PBTK NA 50% Rat Human +DTXSID0025789 Css NA 0.07289 mg/L PBTK NA 95% Rat Human +DTXSID0025812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025812 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025812 Vd NA 1.525 L/kg 1compartment NA NA Human Human DTXSID0025812 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025812 TK.Half.Life NA 4.557 hours 1compartment NA NA Human Human -DTXSID0025812 Css NA 0.1748 mg/L 3compartmentss NA 50% Human Human -DTXSID0025812 Css NA 1.283 mg/L 3compartmentss NA 95% Human Human -DTXSID0025812 Css NA 0.1206 mg/L PBTK NA 50% Human Human -DTXSID0025812 Css NA 0.8387 mg/L PBTK NA 95% Human Human -DTXSID0025812 Clint NA 48.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025812 Fup NA 0.1089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025812 Vd NA 1.701 L/kg 1compartment NA NA Rat Human +DTXSID0025812 TK.Half.Life NA 4.114 hours 1compartment NA NA Human Human +DTXSID0025812 Css NA 0.28 mg/L 3compartmentss NA 50% Human Human +DTXSID0025812 Css NA 2.111 mg/L 3compartmentss NA 95% Human Human +DTXSID0025812 Css NA 0.1868 mg/L PBTK NA 50% Human Human +DTXSID0025812 Css NA 1.344 mg/L PBTK NA 95% Human Human +DTXSID0025812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025812 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025812 Vd NA 1.169 L/kg 1compartment NA NA Rat Human DTXSID0025812 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025812 TK.Half.Life NA 1.407 hours 1compartment NA NA Rat Human -DTXSID0025812 Css NA 0.09943 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025812 Css NA 0.5489 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025812 Css NA 0.06493 mg/L PBTK NA 50% Rat Human -DTXSID0025812 Css NA 0.3461 mg/L PBTK NA 95% Rat Human +DTXSID0025812 TK.Half.Life NA 1.583 hours 1compartment NA NA Rat Human +DTXSID0025812 Css NA 0.03645 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025812 Css NA 0.2152 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025812 Css NA 0.0239 mg/L PBTK NA 50% Rat Human +DTXSID0025812 Css NA 0.1329 mg/L PBTK NA 95% Rat Human DTXSID0025814 Clint NA 0.01073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0025814 Fup NA 0.4601 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025814 Vd NA 0.4915 L/kg 1compartment NA NA Human Human +DTXSID0025814 Vd NA 0.4973 L/kg 1compartment NA NA Human Human DTXSID0025814 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025814 TK.Half.Life NA 6.762 hours 1compartment NA NA Human Human -DTXSID0025814 Css NA 1.554 mg/L 3compartmentss NA 50% Human Human -DTXSID0025814 Css NA 7.443 mg/L 3compartmentss NA 95% Human Human -DTXSID0025814 Css NA 1.146 mg/L PBTK NA 50% Human Human -DTXSID0025814 Css NA 4.758 mg/L PBTK NA 95% Human Human +DTXSID0025814 TK.Half.Life NA 6.843 hours 1compartment NA NA Human Human +DTXSID0025814 Css NA 1.33 mg/L 3compartmentss NA 50% Human Human +DTXSID0025814 Css NA 6.4 mg/L 3compartmentss NA 95% Human Human +DTXSID0025814 Css NA 0.9792 mg/L PBTK NA 50% Human Human +DTXSID0025814 Css NA 4.017 mg/L PBTK NA 95% Human Human DTXSID0025814 Clint NA 0.01073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0025814 Fup NA 0.4601 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025814 Vd NA 0.5143 L/kg 1compartment NA NA Rat Human +DTXSID0025814 Vd NA 0.5203 L/kg 1compartment NA NA Rat Human DTXSID0025814 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025814 TK.Half.Life NA 2.438 hours 1compartment NA NA Rat Human -DTXSID0025814 Css NA 0.4331 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025814 Css NA 1.866 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025814 Css NA 0.3042 mg/L PBTK NA 50% Rat Human -DTXSID0025814 Css NA 1.093 mg/L PBTK NA 95% Rat Human +DTXSID0025814 TK.Half.Life NA 2.467 hours 1compartment NA NA Rat Human +DTXSID0025814 Css NA 0.02428 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025814 Css NA 0.1694 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025814 Css NA 0.01753 mg/L PBTK NA 50% Rat Human +DTXSID0025814 Css NA 0.1063 mg/L PBTK NA 95% Rat Human DTXSID0025816 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0025816 Fup NA 0.5019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025816 Vd NA 0.5199 L/kg 1compartment NA NA Human Human +DTXSID0025816 Vd NA 0.502 L/kg 1compartment NA NA Human Human DTXSID0025816 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025816 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human -DTXSID0025816 Css NA 1.512 mg/L 3compartmentss NA 50% Human Human -DTXSID0025816 Css NA 7.701 mg/L 3compartmentss NA 95% Human Human -DTXSID0025816 Css NA 1.128 mg/L PBTK NA 50% Human Human -DTXSID0025816 Css NA 4.79 mg/L PBTK NA 95% Human Human +DTXSID0025816 TK.Half.Life NA 6.472 hours 1compartment NA NA Human Human +DTXSID0025816 Css NA 1.263 mg/L 3compartmentss NA 50% Human Human +DTXSID0025816 Css NA 6.502 mg/L 3compartmentss NA 95% Human Human +DTXSID0025816 Css NA 0.9465 mg/L PBTK NA 50% Human Human +DTXSID0025816 Css NA 4.12 mg/L PBTK NA 95% Human Human DTXSID0025816 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0025816 Fup NA 0.5019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025816 Vd NA 0.5445 L/kg 1compartment NA NA Rat Human +DTXSID0025816 Vd NA 0.5288 L/kg 1compartment NA NA Rat Human DTXSID0025816 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025816 TK.Half.Life NA 2.392 hours 1compartment NA NA Rat Human -DTXSID0025816 Css NA 0.3992 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025816 Css NA 1.832 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025816 Css NA 0.2858 mg/L PBTK NA 50% Rat Human -DTXSID0025816 Css NA 1.075 mg/L PBTK NA 95% Rat Human -DTXSID0025818 Clint NA 319 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025818 Fup NA 0.0488 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025818 Vd NA 2.852 L/kg 1compartment NA NA Human Human -DTXSID0025818 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025818 TK.Half.Life NA 4.229 hours 1compartment NA NA Human Human -DTXSID0025818 Css NA 0.08948 mg/L 3compartmentss NA 50% Human Human -DTXSID0025818 Css NA 0.6177 mg/L 3compartmentss NA 95% Human Human -DTXSID0025818 Css NA 0.0614 mg/L PBTK NA 50% Human Human -DTXSID0025818 Css NA 0.4071 mg/L PBTK NA 95% Human Human -DTXSID0025818 Clint NA 319 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025818 Fup NA 0.0488 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025818 Vd NA 2.139 L/kg 1compartment NA NA Rat Human -DTXSID0025818 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025818 TK.Half.Life NA 1.116 hours 1compartment NA NA Rat Human -DTXSID0025818 Css NA 0.05078 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025818 Css NA 0.284 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025818 Css NA 0.03323 mg/L PBTK NA 50% Rat Human -DTXSID0025818 Css NA 0.1795 mg/L PBTK NA 95% Rat Human -DTXSID0025862 Clint NA 9.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025862 Fup NA 0.5144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025862 Vd NA 0.944 L/kg 1compartment NA NA Human Human +DTXSID0025816 TK.Half.Life NA 2.323 hours 1compartment NA NA Rat Human +DTXSID0025816 Css NA 0.02373 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025816 Css NA 0.1601 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025816 Css NA 0.01698 mg/L PBTK NA 50% Rat Human +DTXSID0025816 Css NA 0.1013 mg/L PBTK NA 95% Rat Human +DTXSID0025818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025818 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025818 Vd NA 3.002 L/kg 1compartment NA NA Human Human +DTXSID0025818 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0025818 TK.Half.Life NA 23.56 hours 1compartment NA NA Human Human +DTXSID0025818 Css NA 0.8694 mg/L 3compartmentss NA 50% Human Human +DTXSID0025818 Css NA 5.431 mg/L 3compartmentss NA 95% Human Human +DTXSID0025818 Css NA 0.6079 mg/L PBTK NA 50% Human Human +DTXSID0025818 Css NA 3.621 mg/L PBTK NA 95% Human Human +DTXSID0025818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025818 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025818 Vd NA 2.259 L/kg 1compartment NA NA Rat Human +DTXSID0025818 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0025818 TK.Half.Life NA 4.08 hours 1compartment NA NA Rat Human +DTXSID0025818 Css NA 0.1114 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025818 Css NA 0.5786 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025818 Css NA 0.07789 mg/L PBTK NA 50% Rat Human +DTXSID0025818 Css NA 0.3906 mg/L PBTK NA 95% Rat Human +DTXSID0025862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025862 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025862 Vd NA 0.9241 L/kg 1compartment NA NA Human Human DTXSID0025862 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025862 TK.Half.Life NA 1.253 hours 1compartment NA NA Human Human -DTXSID0025862 Css NA 0.08414 mg/L 3compartmentss NA 50% Human Human -DTXSID0025862 Css NA 0.6826 mg/L 3compartmentss NA 95% Human Human -DTXSID0025862 Css NA 0.06794 mg/L PBTK NA 50% Human Human -DTXSID0025862 Css NA 0.4723 mg/L PBTK NA 95% Human Human -DTXSID0025862 Clint NA 9.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025862 Fup NA 0.5144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025862 Vd NA 0.8759 L/kg 1compartment NA NA Rat Human +DTXSID0025862 TK.Half.Life NA 0.9119 hours 1compartment NA NA Human Human +DTXSID0025862 Css NA 0.03786 mg/L 3compartmentss NA 50% Human Human +DTXSID0025862 Css NA 0.3386 mg/L 3compartmentss NA 95% Human Human +DTXSID0025862 Css NA 0.03048 mg/L PBTK NA 50% Human Human +DTXSID0025862 Css NA 0.238 mg/L PBTK NA 95% Human Human +DTXSID0025862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025862 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025862 Vd NA 0.8572 L/kg 1compartment NA NA Rat Human DTXSID0025862 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025862 TK.Half.Life NA 0.6161 hours 1compartment NA NA Rat Human -DTXSID0025862 Css NA 0.0437 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025862 Css NA 0.2922 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025862 Css NA 0.03414 mg/L PBTK NA 50% Rat Human -DTXSID0025862 Css NA 0.1852 mg/L PBTK NA 95% Rat Human +DTXSID0025862 TK.Half.Life NA 0.425 hours 1compartment NA NA Rat Human +DTXSID0025862 Css NA 0.004724 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025862 Css NA 0.03464 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025862 Css NA 0.00379 mg/L PBTK NA 50% Rat Human +DTXSID0025862 Css NA 0.02391 mg/L PBTK NA 95% Rat Human DTXSID0025864 Clint 13.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0025864 Fup 0.485 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0025864 Vd NA 1.035 L/kg 1compartment NA NA Human Human DTXSID0025864 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0025864 TK.Half.Life NA 1.226 hours 1compartment NA NA Human Human -DTXSID0025864 Css NA 0.05888 mg/L 3compartmentss NA 50% Human Human -DTXSID0025864 Css NA 0.3423 mg/L 3compartmentss NA 95% Human Human -DTXSID0025864 Css NA 0.04778 mg/L PBTK NA 50% Human Human -DTXSID0025864 Css NA 0.2531 mg/L PBTK NA 95% Human Human +DTXSID0025864 Css NA 0.0555 mg/L 3compartmentss NA 50% Human Human +DTXSID0025864 Css NA 0.336 mg/L 3compartmentss NA 95% Human Human +DTXSID0025864 Css NA 0.0452 mg/L PBTK NA 50% Human Human +DTXSID0025864 Css NA 0.2535 mg/L PBTK NA 95% Human Human DTXSID0025864 Clint 13.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0025864 Fup 0.485 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0025864 Vd NA 0.9388 L/kg 1compartment NA NA Rat Human DTXSID0025864 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0025864 TK.Half.Life NA 0.5757 hours 1compartment NA NA Rat Human -DTXSID0025864 Css NA 0.0306 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025864 Css NA 0.1313 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025864 Css NA 0.02435 mg/L PBTK NA 50% Rat Human -DTXSID0025864 Css NA 0.09866 mg/L PBTK NA 95% Rat Human -DTXSID0025866 Clint NA 6.149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025866 Fup NA 0.2968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025866 Vd NA 4.38 L/kg 1compartment NA NA Human Human +DTXSID0025864 Css NA 0.006752 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025864 Css NA 0.02985 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025864 Css NA 0.005565 mg/L PBTK NA 50% Rat Human +DTXSID0025864 Css NA 0.02341 mg/L PBTK NA 95% Rat Human +DTXSID0025866 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025866 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025866 Vd NA 1.266 L/kg 1compartment NA NA Human Human DTXSID0025866 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025866 TK.Half.Life NA 8.009 hours 1compartment NA NA Human Human -DTXSID0025866 Css NA 0.09544 mg/L 3compartmentss NA 50% Human Human -DTXSID0025866 Css NA 0.7899 mg/L 3compartmentss NA 95% Human Human -DTXSID0025866 Css NA 0.1314 mg/L PBTK NA 50% Human Human -DTXSID0025866 Css NA 0.7879 mg/L PBTK NA 95% Human Human -DTXSID0025866 Clint NA 6.149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025866 Fup NA 0.2968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025866 Vd NA 4.438 L/kg 1compartment NA NA Rat Human +DTXSID0025866 TK.Half.Life NA 1.458 hours 1compartment NA NA Human Human +DTXSID0025866 Css NA 0.05324 mg/L 3compartmentss NA 50% Human Human +DTXSID0025866 Css NA 0.4295 mg/L 3compartmentss NA 95% Human Human +DTXSID0025866 Css NA 0.04334 mg/L PBTK NA 50% Human Human +DTXSID0025866 Css NA 0.3079 mg/L PBTK NA 95% Human Human +DTXSID0025866 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025866 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025866 Vd NA 1.266 L/kg 1compartment NA NA Rat Human DTXSID0025866 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025866 TK.Half.Life NA 4.77 hours 1compartment NA NA Rat Human -DTXSID0025866 Css NA 0.04748 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025866 Css NA 0.2989 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025866 Css NA 0.06613 mg/L PBTK NA 50% Rat Human -DTXSID0025866 Css NA 0.2807 mg/L PBTK NA 95% Rat Human -DTXSID0025991 Clint NA 15.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025991 Fup NA 0.3763 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025991 Vd NA 0.7152 L/kg 1compartment NA NA Human Human +DTXSID0025866 TK.Half.Life NA 0.7793 hours 1compartment NA NA Rat Human +DTXSID0025866 Css NA 0.006619 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025866 Css NA 0.04221 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025866 Css NA 0.005417 mg/L PBTK NA 50% Rat Human +DTXSID0025866 Css NA 0.02982 mg/L PBTK NA 95% Rat Human +DTXSID0025991 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025991 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025991 Vd NA 0.8349 L/kg 1compartment NA NA Human Human DTXSID0025991 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0025991 TK.Half.Life NA 0.9588 hours 1compartment NA NA Human Human -DTXSID0025991 Css NA 0.07913 mg/L 3compartmentss NA 50% Human Human -DTXSID0025991 Css NA 0.5578 mg/L 3compartmentss NA 95% Human Human -DTXSID0025991 Css NA 0.05752 mg/L PBTK NA 50% Human Human -DTXSID0025991 Css NA 0.3656 mg/L PBTK NA 95% Human Human -DTXSID0025991 Clint NA 15.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025991 Fup NA 0.3763 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025991 Vd NA 0.6542 L/kg 1compartment NA NA Rat Human +DTXSID0025991 TK.Half.Life NA 1.046 hours 1compartment NA NA Human Human +DTXSID0025991 Css NA 0.06286 mg/L 3compartmentss NA 50% Human Human +DTXSID0025991 Css NA 0.4865 mg/L 3compartmentss NA 95% Human Human +DTXSID0025991 Css NA 0.04617 mg/L PBTK NA 50% Human Human +DTXSID0025991 Css NA 0.3315 mg/L PBTK NA 95% Human Human +DTXSID0025991 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025991 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025991 Vd NA 0.7479 L/kg 1compartment NA NA Rat Human DTXSID0025991 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0025991 TK.Half.Life NA 0.464 hours 1compartment NA NA Rat Human -DTXSID0025991 Css NA 0.04162 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025991 Css NA 0.2336 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025991 Css NA 0.02928 mg/L PBTK NA 50% Rat Human -DTXSID0025991 Css NA 0.1468 mg/L PBTK NA 95% Rat Human -DTXSID0025997 Clint NA 19.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025997 Fup NA 0.0327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0025997 Vd NA 8.247 L/kg 1compartment NA NA Human Human -DTXSID0025997 Days.Css NA 55 Days PBTK NA NA Human Human -DTXSID0025997 TK.Half.Life NA 270.8 hours 1compartment NA NA Human Human -DTXSID0025997 Css NA 2.52 mg/L 3compartmentss NA 50% Human Human -DTXSID0025997 Css NA 14.5 mg/L 3compartmentss NA 95% Human Human -DTXSID0025997 Css NA 2.665 mg/L PBTK NA 50% Human Human -DTXSID0025997 Css NA 14.56 mg/L PBTK NA 95% Human Human -DTXSID0025997 Clint NA 19.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025997 Fup NA 0.0327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0025997 Vd NA 6.437 L/kg 1compartment NA NA Rat Human -DTXSID0025997 Days.Css NA 33 Days PBTK NA NA Rat Human -DTXSID0025997 TK.Half.Life NA 36.71 hours 1compartment NA NA Rat Human -DTXSID0025997 Css NA 1.394 mg/L 3compartmentss NA 50% Rat Human -DTXSID0025997 Css NA 5.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID0025997 Css NA 1.448 mg/L PBTK NA 50% Rat Human -DTXSID0025997 Css NA 6.23 mg/L PBTK NA 95% Rat Human +DTXSID0025991 TK.Half.Life NA 0.4885 hours 1compartment NA NA Rat Human +DTXSID0025991 Css NA 0.007756 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025991 Css NA 0.04521 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025991 Css NA 0.005682 mg/L PBTK NA 50% Rat Human +DTXSID0025991 Css NA 0.03027 mg/L PBTK NA 95% Rat Human +DTXSID0025997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025997 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0025997 Vd NA 12.69 L/kg 1compartment NA NA Human Human +DTXSID0025997 Days.Css NA 81 Days PBTK NA NA Human Human +DTXSID0025997 TK.Half.Life NA 378.1 hours 1compartment NA NA Human Human +DTXSID0025997 Css NA 1.675 mg/L 3compartmentss NA 50% Human Human +DTXSID0025997 Css NA 10.11 mg/L 3compartmentss NA 95% Human Human +DTXSID0025997 Css NA 2.362 mg/L PBTK NA 50% Human Human +DTXSID0025997 Css NA 14.04 mg/L PBTK NA 95% Human Human +DTXSID0025997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025997 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0025997 Vd NA 10.09 L/kg 1compartment NA NA Rat Human +DTXSID0025997 Days.Css NA 49 Days PBTK NA NA Rat Human +DTXSID0025997 TK.Half.Life NA 52.83 hours 1compartment NA NA Rat Human +DTXSID0025997 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human +DTXSID0025997 Css NA 0.964 mg/L 3compartmentss NA 95% Rat Human +DTXSID0025997 Css NA 0.3096 mg/L PBTK NA 50% Rat Human +DTXSID0025997 Css NA 1.486 mg/L PBTK NA 95% Rat Human DTXSID0026040 Clint NA 18.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0026040 Fup NA 0.7787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026040 Vd NA 2.452 L/kg 1compartment NA NA Human Human +DTXSID0026040 Vd NA 4.034 L/kg 1compartment NA NA Human Human DTXSID0026040 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026040 TK.Half.Life NA 1.668 hours 1compartment NA NA Human Human -DTXSID0026040 Css NA 0.02664 mg/L 3compartmentss NA 50% Human Human -DTXSID0026040 Css NA 0.2758 mg/L 3compartmentss NA 95% Human Human -DTXSID0026040 Css NA 0.02786 mg/L PBTK NA 50% Human Human -DTXSID0026040 Css NA 0.2211 mg/L PBTK NA 95% Human Human +DTXSID0026040 TK.Half.Life NA 2.352 hours 1compartment NA NA Human Human +DTXSID0026040 Css NA 0.01884 mg/L 3compartmentss NA 50% Human Human +DTXSID0026040 Css NA 0.2463 mg/L 3compartmentss NA 95% Human Human +DTXSID0026040 Css NA 0.02469 mg/L PBTK NA 50% Human Human +DTXSID0026040 Css NA 0.2155 mg/L PBTK NA 95% Human Human DTXSID0026040 Clint NA 18.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0026040 Fup NA 0.7787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026040 Vd NA 2.492 L/kg 1compartment NA NA Rat Human +DTXSID0026040 Vd NA 4.12 L/kg 1compartment NA NA Rat Human DTXSID0026040 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026040 TK.Half.Life NA 0.8645 hours 1compartment NA NA Rat Human -DTXSID0026040 Css NA 0.01305 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026040 Css NA 0.1316 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026040 Css NA 0.01396 mg/L PBTK NA 50% Rat Human -DTXSID0026040 Css NA 0.1007 mg/L PBTK NA 95% Rat Human +DTXSID0026040 TK.Half.Life NA 1.259 hours 1compartment NA NA Rat Human +DTXSID0026040 Css NA 0.00218 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026040 Css NA 0.02324 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026040 Css NA 0.00306 mg/L PBTK NA 50% Rat Human +DTXSID0026040 Css NA 0.02101 mg/L PBTK NA 95% Rat Human DTXSID0026044 Clint NA 601.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0026044 Fup NA 0.0096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026044 Vd NA 1862 L/kg 1compartment NA NA Human Human -DTXSID0026044 Days.Css NA 503 Days PBTK NA NA Human Human -DTXSID0026044 TK.Half.Life NA 1989 hours 1compartment NA NA Human Human -DTXSID0026044 Css NA 0.0002835 mg/L 3compartmentss NA 50% Human Human -DTXSID0026044 Css NA 0.001742 mg/L 3compartmentss NA 95% Human Human -DTXSID0026044 Css NA 0.08832 mg/L PBTK NA 50% Human Human -DTXSID0026044 Css NA 0.496 mg/L PBTK NA 95% Human Human +DTXSID0026044 Vd NA 3.095 L/kg 1compartment NA NA Human Human +DTXSID0026044 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0026044 TK.Half.Life NA 5.733 hours 1compartment NA NA Human Human +DTXSID0026044 Css NA 0.05984 mg/L 3compartmentss NA 50% Human Human +DTXSID0026044 Css NA 0.469 mg/L 3compartmentss NA 95% Human Human +DTXSID0026044 Css NA 0.04128 mg/L PBTK NA 50% Human Human +DTXSID0026044 Css NA 0.3174 mg/L PBTK NA 95% Human Human DTXSID0026044 Clint NA 601.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0026044 Fup NA 0.0096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026044 Vd NA 1722 L/kg 1compartment NA NA Rat Human -DTXSID0026044 Days.Css NA 349 Days PBTK NA NA Rat Human -DTXSID0026044 TK.Half.Life NA 322.5 hours 1compartment NA NA Rat Human -DTXSID0026044 Css NA 0.0001438 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026044 Css NA 0.0006168 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026044 Css NA 0.04806 mg/L PBTK NA 50% Rat Human -DTXSID0026044 Css NA 0.2059 mg/L PBTK NA 95% Rat Human -DTXSID0026125 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026125 Fup NA 0.7519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026125 Vd NA 1.767 L/kg 1compartment NA NA Human Human -DTXSID0026125 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0026125 TK.Half.Life NA 19.49 hours 1compartment NA NA Human Human -DTXSID0026125 Css NA 1.066 mg/L 3compartmentss NA 50% Human Human -DTXSID0026125 Css NA 6.354 mg/L 3compartmentss NA 95% Human Human -DTXSID0026125 Css NA 0.9829 mg/L PBTK NA 50% Human Human -DTXSID0026125 Css NA 4.405 mg/L PBTK NA 95% Human Human -DTXSID0026125 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026125 Fup NA 0.7519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026125 Vd NA 1.514 L/kg 1compartment NA NA Rat Human +DTXSID0026044 Vd NA 2.317 L/kg 1compartment NA NA Rat Human +DTXSID0026044 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0026044 TK.Half.Life NA 1.261 hours 1compartment NA NA Rat Human +DTXSID0026044 Css NA 0.0006034 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026044 Css NA 0.004464 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026044 Css NA 0.0003997 mg/L PBTK NA 50% Rat Human +DTXSID0026044 Css NA 0.002906 mg/L PBTK NA 95% Rat Human +DTXSID0026098 Clint NA 3.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0026098 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0026098 Vd NA 2.873 L/kg 1compartment NA NA Human Human +DTXSID0026098 Days.Css NA 42 Days PBTK NA NA Human Human +DTXSID0026098 TK.Half.Life NA 206.9 hours 1compartment NA NA Human Human +DTXSID0026098 Css NA 9.426 mg/L 3compartmentss NA 50% Human Human +DTXSID0026098 Css NA 55.58 mg/L 3compartmentss NA 95% Human Human +DTXSID0026098 Css NA 6.449 mg/L PBTK NA 50% Human Human +DTXSID0026098 Css NA 36.21 mg/L PBTK NA 95% Human Human +DTXSID0026098 Clint NA 3.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0026098 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0026098 Vd NA 2.152 L/kg 1compartment NA NA Rat Human +DTXSID0026098 Days.Css NA 22 Days PBTK NA NA Rat Human +DTXSID0026098 TK.Half.Life NA 35.15 hours 1compartment NA NA Rat Human +DTXSID0026098 Css NA 1.174 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026098 Css NA 4.699 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026098 Css NA 0.7919 mg/L PBTK NA 50% Rat Human +DTXSID0026098 Css NA 3.063 mg/L PBTK NA 95% Rat Human +DTXSID0026125 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026125 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026125 Vd NA 1.337 L/kg 1compartment NA NA Human Human +DTXSID0026125 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0026125 TK.Half.Life NA 1.453 hours 1compartment NA NA Human Human +DTXSID0026125 Css NA 0.04798 mg/L 3compartmentss NA 50% Human Human +DTXSID0026125 Css NA 0.3841 mg/L 3compartmentss NA 95% Human Human +DTXSID0026125 Css NA 0.03826 mg/L PBTK NA 50% Human Human +DTXSID0026125 Css NA 0.2682 mg/L PBTK NA 95% Human Human +DTXSID0026125 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026125 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026125 Vd NA 1.135 L/kg 1compartment NA NA Rat Human DTXSID0026125 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026125 TK.Half.Life NA 4.738 hours 1compartment NA NA Rat Human -DTXSID0026125 Css NA 0.2843 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026125 Css NA 1.729 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026125 Css NA 0.255 mg/L PBTK NA 50% Rat Human -DTXSID0026125 Css NA 1.079 mg/L PBTK NA 95% Rat Human -DTXSID0026171 Clint NA 1.167 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026171 Fup NA 0.3702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026171 Vd NA 1.101 L/kg 1compartment NA NA Human Human -DTXSID0026171 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026171 TK.Half.Life NA 7.409 hours 1compartment NA NA Human Human -DTXSID0026171 Css NA 0.7069 mg/L 3compartmentss NA 50% Human Human -DTXSID0026171 Css NA 3.289 mg/L 3compartmentss NA 95% Human Human -DTXSID0026171 Css NA 0.5434 mg/L PBTK NA 50% Human Human -DTXSID0026171 Css NA 2.189 mg/L PBTK NA 95% Human Human -DTXSID0026171 Clint NA 1.167 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026171 Fup NA 0.3702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026171 Vd NA 0.9462 L/kg 1compartment NA NA Rat Human -DTXSID0026171 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026171 TK.Half.Life NA 2.993 hours 1compartment NA NA Rat Human -DTXSID0026171 Css NA 0.2898 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026171 Css NA 1.111 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026171 Css NA 0.2157 mg/L PBTK NA 50% Rat Human -DTXSID0026171 Css NA 0.6787 mg/L PBTK NA 95% Rat Human -DTXSID0026173 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026173 Fup NA 0.9359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026173 Vd NA 0.6688 L/kg 1compartment NA NA Human Human +DTXSID0026125 TK.Half.Life NA 0.6075 hours 1compartment NA NA Rat Human +DTXSID0026125 Css NA 0.005824 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026125 Css NA 0.0368 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026125 Css NA 0.004688 mg/L PBTK NA 50% Rat Human +DTXSID0026125 Css NA 0.02548 mg/L PBTK NA 95% Rat Human +DTXSID0026173 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026173 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026173 Vd NA 0.7714 L/kg 1compartment NA NA Human Human DTXSID0026173 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026173 TK.Half.Life NA 4.621 hours 1compartment NA NA Human Human -DTXSID0026173 Css NA 0.8868 mg/L 3compartmentss NA 50% Human Human -DTXSID0026173 Css NA 3.219 mg/L 3compartmentss NA 95% Human Human -DTXSID0026173 Css NA 0.7215 mg/L PBTK NA 50% Human Human -DTXSID0026173 Css NA 2.218 mg/L PBTK NA 95% Human Human -DTXSID0026173 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026173 Fup NA 0.9359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026173 Vd NA 0.7175 L/kg 1compartment NA NA Rat Human +DTXSID0026173 TK.Half.Life NA 7.468 hours 1compartment NA NA Human Human +DTXSID0026173 Css NA 1.099 mg/L 3compartmentss NA 50% Human Human +DTXSID0026173 Css NA 7.107 mg/L 3compartmentss NA 95% Human Human +DTXSID0026173 Css NA 0.8928 mg/L PBTK NA 50% Human Human +DTXSID0026173 Css NA 4.594 mg/L PBTK NA 95% Human Human +DTXSID0026173 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026173 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026173 Vd NA 0.7638 L/kg 1compartment NA NA Rat Human DTXSID0026173 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026173 TK.Half.Life NA 1.691 hours 1compartment NA NA Rat Human -DTXSID0026173 Css NA 0.2288 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026173 Css NA 0.7678 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026173 Css NA 0.1814 mg/L PBTK NA 50% Rat Human -DTXSID0026173 Css NA 0.4869 mg/L PBTK NA 95% Rat Human -DTXSID0026175 Clint NA 11.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026175 Fup NA 0.5268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026175 Vd NA 0.4169 L/kg 1compartment NA NA Human Human +DTXSID0026173 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human +DTXSID0026173 Css NA 0.06513 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026173 Css NA 0.4164 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026173 Css NA 0.05298 mg/L PBTK NA 50% Rat Human +DTXSID0026173 Css NA 0.2551 mg/L PBTK NA 95% Rat Human +DTXSID0026175 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026175 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026175 Vd NA 0.4897 L/kg 1compartment NA NA Human Human DTXSID0026175 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026175 TK.Half.Life NA 0.5361 hours 1compartment NA NA Human Human -DTXSID0026175 Css NA 0.07892 mg/L 3compartmentss NA 50% Human Human -DTXSID0026175 Css NA 0.6566 mg/L 3compartmentss NA 95% Human Human -DTXSID0026175 Css NA 0.0564 mg/L PBTK NA 50% Human Human -DTXSID0026175 Css NA 0.4247 mg/L PBTK NA 95% Human Human -DTXSID0026175 Clint NA 11.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026175 Fup NA 0.5268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026175 Vd NA 0.4261 L/kg 1compartment NA NA Rat Human +DTXSID0026175 TK.Half.Life NA 7.384 hours 1compartment NA NA Human Human +DTXSID0026175 Css NA 1.648 mg/L 3compartmentss NA 50% Human Human +DTXSID0026175 Css NA 7.566 mg/L 3compartmentss NA 95% Human Human +DTXSID0026175 Css NA 1.21 mg/L PBTK NA 50% Human Human +DTXSID0026175 Css NA 4.836 mg/L PBTK NA 95% Human Human +DTXSID0026175 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026175 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026175 Vd NA 0.4863 L/kg 1compartment NA NA Rat Human DTXSID0026175 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026175 TK.Half.Life NA 0.2862 hours 1compartment NA NA Rat Human -DTXSID0026175 Css NA 0.04105 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026175 Css NA 0.2818 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026175 Css NA 0.02804 mg/L PBTK NA 50% Rat Human -DTXSID0026175 Css NA 0.1676 mg/L PBTK NA 95% Rat Human +DTXSID0026175 TK.Half.Life NA 2.495 hours 1compartment NA NA Rat Human +DTXSID0026175 Css NA 0.1052 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026175 Css NA 0.4096 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026175 Css NA 0.07639 mg/L PBTK NA 50% Rat Human +DTXSID0026175 Css NA 0.2501 mg/L PBTK NA 95% Rat Human DTXSID0026202 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0026202 Fup NA 0.0576 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0026202 Vd NA 2.37 L/kg 1compartment NA NA Human Human DTXSID0026202 Days.Css NA 179 Days PBTK NA NA Human Human DTXSID0026202 TK.Half.Life NA 722.1 hours 1compartment NA NA Human Human -DTXSID0026202 Css NA 40.91 mg/L 3compartmentss NA 50% Human Human -DTXSID0026202 Css NA 136.1 mg/L 3compartmentss NA 95% Human Human -DTXSID0026202 Css NA 27.42 mg/L PBTK NA 50% Human Human -DTXSID0026202 Css NA 84.87 mg/L PBTK NA 95% Human Human +DTXSID0026202 Css NA 39.94 mg/L 3compartmentss NA 50% Human Human +DTXSID0026202 Css NA 131.6 mg/L 3compartmentss NA 95% Human Human +DTXSID0026202 Css NA 26.86 mg/L PBTK NA 50% Human Human +DTXSID0026202 Css NA 81.89 mg/L PBTK NA 95% Human Human DTXSID0026202 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0026202 Fup NA 0.0576 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0026202 Vd NA 1.778 L/kg 1compartment NA NA Rat Human DTXSID0026202 Days.Css NA 43 Days PBTK NA NA Rat Human DTXSID0026202 TK.Half.Life NA 95.83 hours 1compartment NA NA Rat Human -DTXSID0026202 Css NA 11.24 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026202 Css NA 31.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026202 Css NA 7.16 mg/L PBTK NA 50% Rat Human -DTXSID0026202 Css NA 18.06 mg/L PBTK NA 95% Rat Human +DTXSID0026202 Css NA 2.532 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026202 Css NA 7.038 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026202 Css NA 1.671 mg/L PBTK NA 50% Rat Human +DTXSID0026202 Css NA 4.216 mg/L PBTK NA 95% Rat Human DTXSID0026204 Clint NA 2.849 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0026204 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0026204 Vd NA 2.467 L/kg 1compartment NA NA Human Human DTXSID0026204 Days.Css NA 16 Days PBTK NA NA Human Human DTXSID0026204 TK.Half.Life NA 95 hours 1compartment NA NA Human Human -DTXSID0026204 Css NA 5.358 mg/L 3compartmentss NA 50% Human Human -DTXSID0026204 Css NA 26.73 mg/L 3compartmentss NA 95% Human Human -DTXSID0026204 Css NA 3.609 mg/L PBTK NA 50% Human Human -DTXSID0026204 Css NA 17.31 mg/L PBTK NA 95% Human Human +DTXSID0026204 Css NA 5.302 mg/L 3compartmentss NA 50% Human Human +DTXSID0026204 Css NA 25.33 mg/L 3compartmentss NA 95% Human Human +DTXSID0026204 Css NA 3.566 mg/L PBTK NA 50% Human Human +DTXSID0026204 Css NA 16.26 mg/L PBTK NA 95% Human Human DTXSID0026204 Clint NA 2.849 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0026204 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0026204 Vd NA 1.85 L/kg 1compartment NA NA Rat Human -DTXSID0026204 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID0026204 Days.Css NA 8 Days PBTK NA NA Rat Human DTXSID0026204 TK.Half.Life NA 21.87 hours 1compartment NA NA Rat Human -DTXSID0026204 Css NA 2.729 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026204 Css NA 9.784 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026204 Css NA 1.749 mg/L PBTK NA 50% Rat Human -DTXSID0026204 Css NA 5.805 mg/L PBTK NA 95% Rat Human -DTXSID0026208 Clint NA 6.455 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026208 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026208 Vd NA 0.9149 L/kg 1compartment NA NA Human Human -DTXSID0026208 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID0026208 TK.Half.Life NA 39.09 hours 1compartment NA NA Human Human -DTXSID0026208 Css NA 7.64 mg/L 3compartmentss NA 50% Human Human -DTXSID0026208 Css NA 64.14 mg/L 3compartmentss NA 95% Human Human -DTXSID0026208 Css NA 4.6 mg/L PBTK NA 50% Human Human -DTXSID0026208 Css NA 38.35 mg/L PBTK NA 95% Human Human -DTXSID0026208 Clint NA 6.455 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026208 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026208 Vd NA 0.6758 L/kg 1compartment NA NA Rat Human -DTXSID0026208 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0026208 TK.Half.Life NA 16.97 hours 1compartment NA NA Rat Human -DTXSID0026208 Css NA 4.168 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026208 Css NA 28.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026208 Css NA 2.351 mg/L PBTK NA 50% Rat Human -DTXSID0026208 Css NA 15.39 mg/L PBTK NA 95% Rat Human -DTXSID0026252 Clint NA 87.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026252 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026252 Vd NA 2.004 L/kg 1compartment NA NA Human Human -DTXSID0026252 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026252 TK.Half.Life NA 8.676 hours 1compartment NA NA Human Human -DTXSID0026252 Css NA 0.5728 mg/L 3compartmentss NA 50% Human Human -DTXSID0026252 Css NA 4.887 mg/L 3compartmentss NA 95% Human Human -DTXSID0026252 Css NA 0.3656 mg/L PBTK NA 50% Human Human -DTXSID0026252 Css NA 3.006 mg/L PBTK NA 95% Human Human -DTXSID0026252 Clint NA 87.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026252 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026252 Vd NA 1.486 L/kg 1compartment NA NA Rat Human -DTXSID0026252 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026252 TK.Half.Life NA 2.803 hours 1compartment NA NA Rat Human -DTXSID0026252 Css NA 0.3258 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026252 Css NA 2.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026252 Css NA 0.196 mg/L PBTK NA 50% Rat Human -DTXSID0026252 Css NA 1.332 mg/L PBTK NA 95% Rat Human -DTXSID0026258 Clint NA 517.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026258 Fup NA 0.1826 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026258 Vd NA 0.6303 L/kg 1compartment NA NA Human Human -DTXSID0026258 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026258 TK.Half.Life NA 0.5454 hours 1compartment NA NA Human Human -DTXSID0026258 Css NA 0.005428 mg/L 3compartmentss NA 50% Human Human -DTXSID0026258 Css NA 0.04111 mg/L 3compartmentss NA 95% Human Human -DTXSID0026258 Css NA 0.003666 mg/L PBTK NA 50% Human Human -DTXSID0026258 Css NA 0.02693 mg/L PBTK NA 95% Human Human -DTXSID0026258 Clint NA 517.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026258 Fup NA 0.1826 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026258 Vd NA 0.5589 L/kg 1compartment NA NA Rat Human +DTXSID0026204 Css NA 0.6164 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026204 Css NA 2.256 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026204 Css NA 0.4102 mg/L PBTK NA 50% Rat Human +DTXSID0026204 Css NA 1.405 mg/L PBTK NA 95% Rat Human +DTXSID0026208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026208 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026208 Vd NA 0.9114 L/kg 1compartment NA NA Human Human +DTXSID0026208 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0026208 TK.Half.Life NA 12.81 hours 1compartment NA NA Human Human +DTXSID0026208 Css NA 2.359 mg/L 3compartmentss NA 50% Human Human +DTXSID0026208 Css NA 22.56 mg/L 3compartmentss NA 95% Human Human +DTXSID0026208 Css NA 1.417 mg/L PBTK NA 50% Human Human +DTXSID0026208 Css NA 13.29 mg/L PBTK NA 95% Human Human +DTXSID0026208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026208 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026208 Vd NA 0.6728 L/kg 1compartment NA NA Rat Human +DTXSID0026208 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0026208 TK.Half.Life NA 5.728 hours 1compartment NA NA Rat Human +DTXSID0026208 Css NA 0.3136 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026208 Css NA 2.491 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026208 Css NA 0.1829 mg/L PBTK NA 50% Rat Human +DTXSID0026208 Css NA 1.415 mg/L PBTK NA 95% Rat Human +DTXSID0026252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026252 Fup 0.00305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026252 Vd NA 2.637 L/kg 1compartment NA NA Human Human +DTXSID0026252 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID0026252 TK.Half.Life NA 73.85 hours 1compartment NA NA Human Human +DTXSID0026252 Css NA 3.902 mg/L 3compartmentss NA 50% Human Human +DTXSID0026252 Css NA 25.7 mg/L 3compartmentss NA 95% Human Human +DTXSID0026252 Css NA 2.581 mg/L PBTK NA 50% Human Human +DTXSID0026252 Css NA 16.37 mg/L PBTK NA 95% Human Human +DTXSID0026252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026252 Fup 0.00305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026252 Vd NA 1.965 L/kg 1compartment NA NA Rat Human +DTXSID0026252 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID0026252 TK.Half.Life NA 16.26 hours 1compartment NA NA Rat Human +DTXSID0026252 Css NA 0.5058 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026252 Css NA 2.898 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026252 Css NA 0.3291 mg/L PBTK NA 50% Rat Human +DTXSID0026252 Css NA 1.846 mg/L PBTK NA 95% Rat Human +DTXSID0026258 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026258 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026258 Vd NA 0.8211 L/kg 1compartment NA NA Human Human +DTXSID0026258 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0026258 TK.Half.Life NA 16.93 hours 1compartment NA NA Human Human +DTXSID0026258 Css NA 2.226 mg/L 3compartmentss NA 50% Human Human +DTXSID0026258 Css NA 9.017 mg/L 3compartmentss NA 95% Human Human +DTXSID0026258 Css NA 1.654 mg/L PBTK NA 50% Human Human +DTXSID0026258 Css NA 5.749 mg/L PBTK NA 95% Human Human +DTXSID0026258 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026258 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026258 Vd NA 0.7394 L/kg 1compartment NA NA Rat Human DTXSID0026258 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026258 TK.Half.Life NA 0.2159 hours 1compartment NA NA Rat Human -DTXSID0026258 Css NA 0.003094 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026258 Css NA 0.01851 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026258 Css NA 0.001974 mg/L PBTK NA 50% Rat Human -DTXSID0026258 Css NA 0.01122 mg/L PBTK NA 95% Rat Human -DTXSID0026339 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026339 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026339 Vd NA 1667 L/kg 1compartment NA NA Human Human -DTXSID0026339 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID0026339 TK.Half.Life NA 49510000 hours 1compartment NA NA Human Human -DTXSID0026339 Css NA 8.942 mg/L 3compartmentss NA 50% Human Human -DTXSID0026339 Css NA 35.76 mg/L 3compartmentss NA 95% Human Human -DTXSID0026339 Css NA 2440 mg/L PBTK NA 50% Human Human -DTXSID0026339 Css NA 5848 mg/L PBTK NA 95% Human Human -DTXSID0026339 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026339 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026339 Vd NA 1539 L/kg 1compartment NA NA Rat Human -DTXSID0026339 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID0026339 TK.Half.Life NA 4227000 hours 1compartment NA NA Rat Human -DTXSID0026339 Css NA 2.102 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026339 Css NA 8.847 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026339 Css NA 634 mg/L PBTK NA 50% Rat Human -DTXSID0026339 Css NA 1302 mg/L PBTK NA 95% Rat Human -DTXSID0026547 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026547 Fup NA 0.2661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026547 Vd NA 0.3562 L/kg 1compartment NA NA Human Human +DTXSID0026258 TK.Half.Life NA 5.034 hours 1compartment NA NA Rat Human +DTXSID0026258 Css NA 0.14 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026258 Css NA 0.4926 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026258 Css NA 0.1032 mg/L PBTK NA 50% Rat Human +DTXSID0026258 Css NA 0.3044 mg/L PBTK NA 95% Rat Human +DTXSID0026547 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026547 Fup 0.0643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026547 Vd NA 0.6218 L/kg 1compartment NA NA Human Human DTXSID0026547 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026547 TK.Half.Life NA 8.672 hours 1compartment NA NA Human Human -DTXSID0026547 Css NA 3 mg/L 3compartmentss NA 50% Human Human -DTXSID0026547 Css NA 11.47 mg/L 3compartmentss NA 95% Human Human -DTXSID0026547 Css NA 1.982 mg/L PBTK NA 50% Human Human -DTXSID0026547 Css NA 6.974 mg/L PBTK NA 95% Human Human -DTXSID0026547 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026547 Fup NA 0.2661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026547 Vd NA 0.355 L/kg 1compartment NA NA Rat Human +DTXSID0026547 TK.Half.Life NA 2.196 hours 1compartment NA NA Human Human +DTXSID0026547 Css NA 0.4531 mg/L 3compartmentss NA 50% Human Human +DTXSID0026547 Css NA 3.572 mg/L 3compartmentss NA 95% Human Human +DTXSID0026547 Css NA 0.2788 mg/L PBTK NA 50% Human Human +DTXSID0026547 Css NA 2.152 mg/L PBTK NA 95% Human Human +DTXSID0026547 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026547 Fup 0.0643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026547 Vd NA 0.4935 L/kg 1compartment NA NA Rat Human DTXSID0026547 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026547 TK.Half.Life NA 2.943 hours 1compartment NA NA Rat Human -DTXSID0026547 Css NA 0.8453 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026547 Css NA 2.664 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026547 Css NA 0.5264 mg/L PBTK NA 50% Rat Human -DTXSID0026547 Css NA 1.515 mg/L PBTK NA 95% Rat Human +DTXSID0026547 TK.Half.Life NA 1.041 hours 1compartment NA NA Rat Human +DTXSID0026547 Css NA 0.05946 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026547 Css NA 0.3537 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026547 Css NA 0.03554 mg/L PBTK NA 50% Rat Human +DTXSID0026547 Css NA 0.2048 mg/L PBTK NA 95% Rat Human DTXSID0026549 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0026549 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026549 Vd NA 0.7005 L/kg 1compartment NA NA Human Human +DTXSID0026549 Vd NA 0.6936 L/kg 1compartment NA NA Human Human DTXSID0026549 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026549 TK.Half.Life NA 4.533 hours 1compartment NA NA Human Human -DTXSID0026549 Css NA 0.8464 mg/L 3compartmentss NA 50% Human Human -DTXSID0026549 Css NA 5.575 mg/L 3compartmentss NA 95% Human Human -DTXSID0026549 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID0026549 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID0026549 TK.Half.Life NA 4.489 hours 1compartment NA NA Human Human +DTXSID0026549 Css NA 0.7357 mg/L 3compartmentss NA 50% Human Human +DTXSID0026549 Css NA 4.923 mg/L 3compartmentss NA 95% Human Human +DTXSID0026549 Css NA 0.6056 mg/L PBTK NA 50% Human Human +DTXSID0026549 Css NA 3.216 mg/L PBTK NA 95% Human Human DTXSID0026549 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0026549 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026549 Vd NA 0.7507 L/kg 1compartment NA NA Rat Human +DTXSID0026549 Vd NA 0.745 L/kg 1compartment NA NA Rat Human DTXSID0026549 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026549 TK.Half.Life NA 1.655 hours 1compartment NA NA Rat Human -DTXSID0026549 Css NA 0.2127 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026549 Css NA 1.338 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026549 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0026549 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0026676 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026676 Fup NA 0.0471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026676 Vd NA 1.866 L/kg 1compartment NA NA Human Human -DTXSID0026676 Days.Css NA 107 Days PBTK NA NA Human Human -DTXSID0026676 TK.Half.Life NA 447.5 hours 1compartment NA NA Human Human -DTXSID0026676 Css NA 34.97 mg/L 3compartmentss NA 50% Human Human -DTXSID0026676 Css NA 132.8 mg/L 3compartmentss NA 95% Human Human -DTXSID0026676 Css NA 22.68 mg/L PBTK NA 50% Human Human -DTXSID0026676 Css NA 79.97 mg/L PBTK NA 95% Human Human -DTXSID0026676 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026676 Fup NA 0.0471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026676 Vd NA 1.397 L/kg 1compartment NA NA Rat Human -DTXSID0026676 Days.Css NA 25 Days PBTK NA NA Rat Human -DTXSID0026676 TK.Half.Life NA 77.03 hours 1compartment NA NA Rat Human -DTXSID0026676 Css NA 9.672 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026676 Css NA 31.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026676 Css NA 5.933 mg/L PBTK NA 50% Rat Human -DTXSID0026676 Css NA 17.63 mg/L PBTK NA 95% Rat Human -DTXSID0026701 Clint NA 0.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026701 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026701 Vd NA 0.4776 L/kg 1compartment NA NA Human Human +DTXSID0026549 TK.Half.Life NA 1.643 hours 1compartment NA NA Rat Human +DTXSID0026549 Css NA 0.01838 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026549 Css NA 0.131 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026549 Css NA 0.01478 mg/L PBTK NA 50% Rat Human +DTXSID0026549 Css NA 0.08478 mg/L PBTK NA 95% Rat Human +DTXSID0026676 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026676 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026676 Vd NA 1.207 L/kg 1compartment NA NA Human Human +DTXSID0026676 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID0026676 TK.Half.Life NA 55.85 hours 1compartment NA NA Human Human +DTXSID0026676 Css NA 7.928 mg/L 3compartmentss NA 50% Human Human +DTXSID0026676 Css NA 66.64 mg/L 3compartmentss NA 95% Human Human +DTXSID0026676 Css NA 4.854 mg/L PBTK NA 50% Human Human +DTXSID0026676 Css NA 39.41 mg/L PBTK NA 95% Human Human +DTXSID0026676 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026676 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026676 Vd NA 0.8895 L/kg 1compartment NA NA Rat Human +DTXSID0026676 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0026676 TK.Half.Life NA 22.68 hours 1compartment NA NA Rat Human +DTXSID0026676 Css NA 0.9998 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026676 Css NA 6.595 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026676 Css NA 0.5914 mg/L PBTK NA 50% Rat Human +DTXSID0026676 Css NA 3.771 mg/L PBTK NA 95% Rat Human +DTXSID0026701 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026701 Fup 0.366 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026701 Vd NA 0.4528 L/kg 1compartment NA NA Human Human DTXSID0026701 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026701 TK.Half.Life NA 7.834 hours 1compartment NA NA Human Human -DTXSID0026701 Css NA 1.861 mg/L 3compartmentss NA 50% Human Human -DTXSID0026701 Css NA 7.666 mg/L 3compartmentss NA 95% Human Human -DTXSID0026701 Css NA 1.302 mg/L PBTK NA 50% Human Human -DTXSID0026701 Css NA 4.768 mg/L PBTK NA 95% Human Human -DTXSID0026701 Clint NA 0.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026701 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026701 Vd NA 0.4809 L/kg 1compartment NA NA Rat Human +DTXSID0026701 TK.Half.Life NA 0.9098 hours 1compartment NA NA Human Human +DTXSID0026701 Css NA 0.1612 mg/L 3compartmentss NA 50% Human Human +DTXSID0026701 Css NA 1.055 mg/L 3compartmentss NA 95% Human Human +DTXSID0026701 Css NA 0.1134 mg/L PBTK NA 50% Human Human +DTXSID0026701 Css NA 0.691 mg/L PBTK NA 95% Human Human +DTXSID0026701 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026701 Fup 0.366 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026701 Vd NA 0.4708 L/kg 1compartment NA NA Rat Human DTXSID0026701 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026701 TK.Half.Life NA 3.371 hours 1compartment NA NA Rat Human -DTXSID0026701 Css NA 0.6588 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026701 Css NA 2.201 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026701 Css NA 0.4376 mg/L PBTK NA 50% Rat Human -DTXSID0026701 Css NA 1.283 mg/L PBTK NA 95% Rat Human -DTXSID0026830 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026830 Fup NA 0.622 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026830 Vd NA 1.479 L/kg 1compartment NA NA Human Human -DTXSID0026830 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0026830 TK.Half.Life NA 18.1 hours 1compartment NA NA Human Human -DTXSID0026830 Css NA 1.234 mg/L 3compartmentss NA 50% Human Human -DTXSID0026830 Css NA 8.27 mg/L 3compartmentss NA 95% Human Human -DTXSID0026830 Css NA 1.082 mg/L PBTK NA 50% Human Human -DTXSID0026830 Css NA 5.47 mg/L PBTK NA 95% Human Human -DTXSID0026830 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026830 Fup NA 0.622 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026830 Vd NA 1.282 L/kg 1compartment NA NA Rat Human +DTXSID0026701 TK.Half.Life NA 0.5287 hours 1compartment NA NA Rat Human +DTXSID0026701 Css NA 0.01912 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026701 Css NA 0.09369 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026701 Css NA 0.01337 mg/L PBTK NA 50% Rat Human +DTXSID0026701 Css NA 0.05906 mg/L PBTK NA 95% Rat Human +DTXSID0026830 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026830 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026830 Vd NA 0.7705 L/kg 1compartment NA NA Human Human +DTXSID0026830 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0026830 TK.Half.Life NA 7.727 hours 1compartment NA NA Human Human +DTXSID0026830 Css NA 0.9611 mg/L 3compartmentss NA 50% Human Human +DTXSID0026830 Css NA 6.55 mg/L 3compartmentss NA 95% Human Human +DTXSID0026830 Css NA 0.7901 mg/L PBTK NA 50% Human Human +DTXSID0026830 Css NA 4.149 mg/L PBTK NA 95% Human Human +DTXSID0026830 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026830 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026830 Vd NA 0.7701 L/kg 1compartment NA NA Rat Human DTXSID0026830 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026830 TK.Half.Life NA 4.735 hours 1compartment NA NA Rat Human -DTXSID0026830 Css NA 0.327 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026830 Css NA 2.053 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026830 Css NA 0.278 mg/L PBTK NA 50% Rat Human -DTXSID0026830 Css NA 1.25 mg/L PBTK NA 95% Rat Human -DTXSID0026838 Clint NA 17.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026838 Fup NA 0.0116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026838 Vd NA 13.33 L/kg 1compartment NA NA Human Human -DTXSID0026838 Days.Css NA 108 Days PBTK NA NA Human Human -DTXSID0026838 TK.Half.Life NA 481.4 hours 1compartment NA NA Human Human -DTXSID0026838 Css NA 1.986 mg/L 3compartmentss NA 50% Human Human -DTXSID0026838 Css NA 11.84 mg/L 3compartmentss NA 95% Human Human -DTXSID0026838 Css NA 2.964 mg/L PBTK NA 50% Human Human -DTXSID0026838 Css NA 16.89 mg/L PBTK NA 95% Human Human -DTXSID0026838 Clint NA 17.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026838 Fup NA 0.0116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026838 Vd NA 10.62 L/kg 1compartment NA NA Rat Human -DTXSID0026838 Days.Css NA 64 Days PBTK NA NA Rat Human -DTXSID0026838 TK.Half.Life NA 67.56 hours 1compartment NA NA Rat Human -DTXSID0026838 Css NA 1.07 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026838 Css NA 4.54 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026838 Css NA 1.598 mg/L PBTK NA 50% Rat Human -DTXSID0026838 Css NA 6.931 mg/L PBTK NA 95% Rat Human -DTXSID0026880 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026880 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026880 Vd NA 1.073 L/kg 1compartment NA NA Human Human +DTXSID0026830 TK.Half.Life NA 2.617 hours 1compartment NA NA Rat Human +DTXSID0026830 Css NA 0.01837 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026830 Css NA 0.1529 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026830 Css NA 0.01442 mg/L PBTK NA 50% Rat Human +DTXSID0026830 Css NA 0.09791 mg/L PBTK NA 95% Rat Human +DTXSID0026880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026880 Fup 0.86 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026880 Vd NA 0.9215 L/kg 1compartment NA NA Human Human DTXSID0026880 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026880 TK.Half.Life NA 7.077 hours 1compartment NA NA Human Human -DTXSID0026880 Css NA 0.7736 mg/L 3compartmentss NA 50% Human Human -DTXSID0026880 Css NA 5.799 mg/L 3compartmentss NA 95% Human Human -DTXSID0026880 Css NA 0.7002 mg/L PBTK NA 50% Human Human -DTXSID0026880 Css NA 3.918 mg/L PBTK NA 95% Human Human -DTXSID0026880 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026880 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026880 Vd NA 1.061 L/kg 1compartment NA NA Rat Human +DTXSID0026880 TK.Half.Life NA 0.6802 hours 1compartment NA NA Human Human +DTXSID0026880 Css NA 0.02456 mg/L 3compartmentss NA 50% Human Human +DTXSID0026880 Css NA 0.2777 mg/L 3compartmentss NA 95% Human Human +DTXSID0026880 Css NA 0.0207 mg/L PBTK NA 50% Human Human +DTXSID0026880 Css NA 0.1948 mg/L PBTK NA 95% Human Human +DTXSID0026880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026880 Fup 0.86 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026880 Vd NA 0.921 L/kg 1compartment NA NA Rat Human DTXSID0026880 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026880 TK.Half.Life NA 2.35 hours 1compartment NA NA Rat Human -DTXSID0026880 Css NA 0.1948 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026880 Css NA 1.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026880 Css NA 0.1734 mg/L PBTK NA 50% Rat Human -DTXSID0026880 Css NA 0.795 mg/L PBTK NA 95% Rat Human -DTXSID0026915 Clint NA 23.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026915 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026915 Vd NA 3.017 L/kg 1compartment NA NA Human Human -DTXSID0026915 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0026915 TK.Half.Life NA 34.52 hours 1compartment NA NA Human Human -DTXSID0026915 Css NA 1.358 mg/L 3compartmentss NA 50% Human Human -DTXSID0026915 Css NA 8.729 mg/L 3compartmentss NA 95% Human Human -DTXSID0026915 Css NA 0.9451 mg/L PBTK NA 50% Human Human -DTXSID0026915 Css NA 5.85 mg/L PBTK NA 95% Human Human -DTXSID0026915 Clint NA 23.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026915 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026915 Vd NA 2.263 L/kg 1compartment NA NA Rat Human -DTXSID0026915 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0026915 TK.Half.Life NA 5.613 hours 1compartment NA NA Rat Human -DTXSID0026915 Css NA 0.7627 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026915 Css NA 3.877 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026915 Css NA 0.5062 mg/L PBTK NA 50% Rat Human -DTXSID0026915 Css NA 2.52 mg/L PBTK NA 95% Rat Human -DTXSID0026961 Clint NA 0.2137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026961 Fup NA 0.1554 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026961 Vd NA 0.9854 L/kg 1compartment NA NA Human Human -DTXSID0026961 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID0026961 TK.Half.Life NA 33.65 hours 1compartment NA NA Human Human -DTXSID0026961 Css NA 4.447 mg/L 3compartmentss NA 50% Human Human -DTXSID0026961 Css NA 19.12 mg/L 3compartmentss NA 95% Human Human -DTXSID0026961 Css NA 2.969 mg/L PBTK NA 50% Human Human -DTXSID0026961 Css NA 11.72 mg/L PBTK NA 95% Human Human -DTXSID0026961 Clint NA 0.2137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026961 Fup NA 0.1554 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026961 Vd NA 0.7864 L/kg 1compartment NA NA Rat Human -DTXSID0026961 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0026961 TK.Half.Life NA 9.711 hours 1compartment NA NA Rat Human -DTXSID0026961 Css NA 1.472 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026961 Css NA 5.493 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026961 Css NA 0.9308 mg/L PBTK NA 50% Rat Human -DTXSID0026961 Css NA 3.124 mg/L PBTK NA 95% Rat Human +DTXSID0026880 TK.Half.Life NA 0.3276 hours 1compartment NA NA Rat Human +DTXSID0026880 Css NA 0.002886 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026880 Css NA 0.02525 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026880 Css NA 0.002488 mg/L PBTK NA 50% Rat Human +DTXSID0026880 Css NA 0.01761 mg/L PBTK NA 95% Rat Human +DTXSID0026915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026915 Fup 0.0646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026915 Vd NA 3.072 L/kg 1compartment NA NA Human Human +DTXSID0026915 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0026915 TK.Half.Life NA 50.93 hours 1compartment NA NA Human Human +DTXSID0026915 Css NA 1.904 mg/L 3compartmentss NA 50% Human Human +DTXSID0026915 Css NA 12.66 mg/L 3compartmentss NA 95% Human Human +DTXSID0026915 Css NA 1.329 mg/L PBTK NA 50% Human Human +DTXSID0026915 Css NA 8.584 mg/L PBTK NA 95% Human Human +DTXSID0026915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026915 Fup 0.0646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026915 Vd NA 2.303 L/kg 1compartment NA NA Rat Human +DTXSID0026915 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0026915 TK.Half.Life NA 7.537 hours 1compartment NA NA Rat Human +DTXSID0026915 Css NA 0.2504 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026915 Css NA 1.36 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026915 Css NA 0.1722 mg/L PBTK NA 50% Rat Human +DTXSID0026915 Css NA 0.9263 mg/L PBTK NA 95% Rat Human +DTXSID0026961 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026961 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026961 Vd NA 0.9419 L/kg 1compartment NA NA Human Human +DTXSID0026961 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0026961 TK.Half.Life NA 1.933 hours 1compartment NA NA Human Human +DTXSID0026961 Css NA 0.1797 mg/L 3compartmentss NA 50% Human Human +DTXSID0026961 Css NA 1.46 mg/L 3compartmentss NA 95% Human Human +DTXSID0026961 Css NA 0.1183 mg/L PBTK NA 50% Human Human +DTXSID0026961 Css NA 0.9101 mg/L PBTK NA 95% Human Human +DTXSID0026961 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026961 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026961 Vd NA 0.752 L/kg 1compartment NA NA Rat Human +DTXSID0026961 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0026961 TK.Half.Life NA 0.841 hours 1compartment NA NA Rat Human +DTXSID0026961 Css NA 0.02346 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026961 Css NA 0.1424 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026961 Css NA 0.01518 mg/L PBTK NA 50% Rat Human +DTXSID0026961 Css NA 0.08806 mg/L PBTK NA 95% Rat Human DTXSID0026967 Clint 843 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0026967 Fup NA 0.0375 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0026967 Vd NA 0.9333 L/kg 1compartment NA NA Human Human +DTXSID0026967 Fup 0.0991 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0026967 Vd NA 2.172 L/kg 1compartment NA NA Human Human DTXSID0026967 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0026967 TK.Half.Life NA 0.9659 hours 1compartment NA NA Human Human -DTXSID0026967 Css NA 0.02162 mg/L 3compartmentss NA 50% Human Human -DTXSID0026967 Css NA 0.2112 mg/L 3compartmentss NA 95% Human Human -DTXSID0026967 Css NA 0.01334 mg/L PBTK NA 50% Human Human -DTXSID0026967 Css NA 0.125 mg/L PBTK NA 95% Human Human +DTXSID0026967 TK.Half.Life NA 1.936 hours 1compartment NA NA Human Human +DTXSID0026967 Css NA 0.008639 mg/L 3compartmentss NA 50% Human Human +DTXSID0026967 Css NA 0.07675 mg/L 3compartmentss NA 95% Human Human +DTXSID0026967 Css NA 0.00586 mg/L PBTK NA 50% Human Human +DTXSID0026967 Css NA 0.05009 mg/L PBTK NA 95% Human Human DTXSID0026967 Clint 843 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0026967 Fup NA 0.0375 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0026967 Vd NA 0.7085 L/kg 1compartment NA NA Rat Human +DTXSID0026967 Fup 0.0991 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0026967 Vd NA 1.642 L/kg 1compartment NA NA Rat Human DTXSID0026967 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0026967 TK.Half.Life NA 0.3375 hours 1compartment NA NA Rat Human -DTXSID0026967 Css NA 0.01281 mg/L 3compartmentss NA 50% Rat Human -DTXSID0026967 Css NA 0.0961 mg/L 3compartmentss NA 95% Rat Human -DTXSID0026967 Css NA 0.007385 mg/L PBTK NA 50% Rat Human -DTXSID0026967 Css NA 0.05383 mg/L PBTK NA 95% Rat Human -DTXSID0027066 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027066 Fup NA 0.048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027066 Vd NA 0.4248 L/kg 1compartment NA NA Human Human -DTXSID0027066 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID0027066 TK.Half.Life NA 58.2 hours 1compartment NA NA Human Human -DTXSID0027066 Css NA 22.1 mg/L 3compartmentss NA 50% Human Human -DTXSID0027066 Css NA 110.8 mg/L 3compartmentss NA 95% Human Human -DTXSID0027066 Css NA 13.7 mg/L PBTK NA 50% Human Human -DTXSID0027066 Css NA 65.96 mg/L PBTK NA 95% Human Human -DTXSID0027066 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027066 Fup NA 0.048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027066 Vd NA 0.3701 L/kg 1compartment NA NA Rat Human -DTXSID0027066 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0027066 TK.Half.Life NA 17.07 hours 1compartment NA NA Rat Human -DTXSID0027066 Css NA 6.268 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027066 Css NA 26.14 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027066 Css NA 3.637 mg/L PBTK NA 50% Rat Human -DTXSID0027066 Css NA 14.38 mg/L PBTK NA 95% Rat Human +DTXSID0026967 TK.Half.Life NA 0.6348 hours 1compartment NA NA Rat Human +DTXSID0026967 Css NA 0.001173 mg/L 3compartmentss NA 50% Rat Human +DTXSID0026967 Css NA 0.008549 mg/L 3compartmentss NA 95% Rat Human +DTXSID0026967 Css NA 0.0007881 mg/L PBTK NA 50% Rat Human +DTXSID0026967 Css NA 0.005725 mg/L PBTK NA 95% Rat Human +DTXSID0027066 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027066 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027066 Vd NA 0.2844 L/kg 1compartment NA NA Human Human +DTXSID0027066 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0027066 TK.Half.Life NA 11.43 hours 1compartment NA NA Human Human +DTXSID0027066 Css NA 5.411 mg/L 3compartmentss NA 50% Human Human +DTXSID0027066 Css NA 22.79 mg/L 3compartmentss NA 95% Human Human +DTXSID0027066 Css NA 3.407 mg/L PBTK NA 50% Human Human +DTXSID0027066 Css NA 13.48 mg/L PBTK NA 95% Human Human +DTXSID0027066 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027066 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027066 Vd NA 0.284 L/kg 1compartment NA NA Rat Human +DTXSID0027066 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0027066 TK.Half.Life NA 3.89 hours 1compartment NA NA Rat Human +DTXSID0027066 Css NA 0.3528 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027066 Css NA 1.204 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027066 Css NA 0.2161 mg/L PBTK NA 50% Rat Human +DTXSID0027066 Css NA 0.6925 mg/L PBTK NA 95% Rat Human DTXSID0027149 Clint NA 0.002983 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0027149 Fup NA 0.4614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0027149 Vd NA 0.4854 L/kg 1compartment NA NA Human Human DTXSID0027149 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0027149 TK.Half.Life NA 6.762 hours 1compartment NA NA Human Human -DTXSID0027149 Css NA 1.588 mg/L 3compartmentss NA 50% Human Human -DTXSID0027149 Css NA 7.735 mg/L 3compartmentss NA 95% Human Human -DTXSID0027149 Css NA 1.173 mg/L PBTK NA 50% Human Human -DTXSID0027149 Css NA 4.858 mg/L PBTK NA 95% Human Human +DTXSID0027149 Css NA 1.339 mg/L 3compartmentss NA 50% Human Human +DTXSID0027149 Css NA 6.525 mg/L 3compartmentss NA 95% Human Human +DTXSID0027149 Css NA 0.9872 mg/L PBTK NA 50% Human Human +DTXSID0027149 Css NA 4.169 mg/L PBTK NA 95% Human Human DTXSID0027149 Clint NA 0.002983 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0027149 Fup NA 0.4614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0027149 Vd NA 0.5071 L/kg 1compartment NA NA Rat Human DTXSID0027149 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0027149 TK.Half.Life NA 2.416 hours 1compartment NA NA Rat Human -DTXSID0027149 Css NA 0.4332 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027149 Css NA 1.883 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027149 Css NA 0.3044 mg/L PBTK NA 50% Rat Human -DTXSID0027149 Css NA 1.102 mg/L PBTK NA 95% Rat Human -DTXSID0027197 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027197 Fup NA 0.9098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027197 Vd NA 0.5246 L/kg 1compartment NA NA Human Human +DTXSID0027149 Css NA 0.02532 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027149 Css NA 0.1664 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027149 Css NA 0.01808 mg/L PBTK NA 50% Rat Human +DTXSID0027149 Css NA 0.1039 mg/L PBTK NA 95% Rat Human +DTXSID0027197 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027197 Fup 0.89 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027197 Vd NA 0.5331 L/kg 1compartment NA NA Human Human DTXSID0027197 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027197 TK.Half.Life NA 3.733 hours 1compartment NA NA Human Human -DTXSID0027197 Css NA 1.007 mg/L 3compartmentss NA 50% Human Human -DTXSID0027197 Css NA 5.506 mg/L 3compartmentss NA 95% Human Human -DTXSID0027197 Css NA 0.7613 mg/L PBTK NA 50% Human Human -DTXSID0027197 Css NA 3.474 mg/L PBTK NA 95% Human Human -DTXSID0027197 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027197 Fup NA 0.9098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027197 Vd NA 0.545 L/kg 1compartment NA NA Rat Human +DTXSID0027197 TK.Half.Life NA 3.877 hours 1compartment NA NA Human Human +DTXSID0027197 Css NA 0.867 mg/L 3compartmentss NA 50% Human Human +DTXSID0027197 Css NA 4.718 mg/L 3compartmentss NA 95% Human Human +DTXSID0027197 Css NA 0.6543 mg/L PBTK NA 50% Human Human +DTXSID0027197 Css NA 2.962 mg/L PBTK NA 95% Human Human +DTXSID0027197 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027197 Fup 0.89 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027197 Vd NA 0.5514 L/kg 1compartment NA NA Rat Human DTXSID0027197 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027197 TK.Half.Life NA 1.321 hours 1compartment NA NA Rat Human -DTXSID0027197 Css NA 0.26 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027197 Css NA 1.346 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027197 Css NA 0.189 mg/L PBTK NA 50% Rat Human -DTXSID0027197 Css NA 0.787 mg/L PBTK NA 95% Rat Human -DTXSID0027270 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027270 Fup NA 0.0185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027270 Vd NA 5.229 L/kg 1compartment NA NA Human Human -DTXSID0027270 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID0027270 TK.Half.Life NA 248800 hours 1compartment NA NA Human Human -DTXSID0027270 Css NA 4420 mg/L 3compartmentss NA 50% Human Human -DTXSID0027270 Css NA 10080 mg/L 3compartmentss NA 95% Human Human -DTXSID0027270 Css NA 3663 mg/L PBTK NA 50% Human Human -DTXSID0027270 Css NA 7949 mg/L PBTK NA 95% Human Human -DTXSID0027270 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027270 Fup NA 0.0185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027270 Vd NA 4.001 L/kg 1compartment NA NA Rat Human -DTXSID0027270 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID0027270 TK.Half.Life NA 15830 hours 1compartment NA NA Rat Human -DTXSID0027270 Css NA 1215 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027270 Css NA 1796 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027270 Css NA 981 mg/L PBTK NA 50% Rat Human -DTXSID0027270 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID0027301 Clint NA 1.985 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027301 Fup NA 0.8308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027301 Vd NA 1.812 L/kg 1compartment NA NA Human Human -DTXSID0027301 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027301 TK.Half.Life NA 3.809 hours 1compartment NA NA Human Human -DTXSID0027301 Css NA 0.1964 mg/L 3compartmentss NA 50% Human Human -DTXSID0027301 Css NA 1.503 mg/L 3compartmentss NA 95% Human Human -DTXSID0027301 Css NA 0.194 mg/L PBTK NA 50% Human Human -DTXSID0027301 Css NA 1.107 mg/L PBTK NA 95% Human Human -DTXSID0027301 Clint NA 1.985 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027301 Fup NA 0.8308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027301 Vd NA 1.828 L/kg 1compartment NA NA Rat Human +DTXSID0027197 TK.Half.Life NA 1.366 hours 1compartment NA NA Rat Human +DTXSID0027197 Css NA 0.01616 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027197 Css NA 0.1098 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027197 Css NA 0.01174 mg/L PBTK NA 50% Rat Human +DTXSID0027197 Css NA 0.06851 mg/L PBTK NA 95% Rat Human +DTXSID0027272 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027272 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027272 Vd NA 101.7 L/kg 1compartment NA NA Human Human +DTXSID0027272 Days.Css NA 783 Days PBTK NA NA Human Human +DTXSID0027272 TK.Half.Life NA 2985 hours 1compartment NA NA Human Human +DTXSID0027272 Css NA 0.1058 mg/L 3compartmentss NA 50% Human Human +DTXSID0027272 Css NA 0.7009 mg/L 3compartmentss NA 95% Human Human +DTXSID0027272 Css NA 1.319 mg/L PBTK NA 50% Human Human +DTXSID0027272 Css NA 8.042 mg/L PBTK NA 95% Human Human +DTXSID0027272 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027272 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027272 Vd NA 87.93 L/kg 1compartment NA NA Rat Human +DTXSID0027272 Days.Css NA 492 Days PBTK NA NA Rat Human +DTXSID0027272 TK.Half.Life NA 439.8 hours 1compartment NA NA Rat Human +DTXSID0027272 Css NA 0.001015 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027272 Css NA 0.006493 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027272 Css NA 0.01349 mg/L PBTK NA 50% Rat Human +DTXSID0027272 Css NA 0.08341 mg/L PBTK NA 95% Rat Human +DTXSID0027301 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027301 Fup 0.645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027301 Vd NA 1.481 L/kg 1compartment NA NA Human Human +DTXSID0027301 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0027301 TK.Half.Life NA 14.86 hours 1compartment NA NA Human Human +DTXSID0027301 Css NA 0.8446 mg/L 3compartmentss NA 50% Human Human +DTXSID0027301 Css NA 6.3 mg/L 3compartmentss NA 95% Human Human +DTXSID0027301 Css NA 0.7903 mg/L PBTK NA 50% Human Human +DTXSID0027301 Css NA 4.273 mg/L PBTK NA 95% Human Human +DTXSID0027301 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027301 Fup 0.645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027301 Vd NA 1.491 L/kg 1compartment NA NA Rat Human DTXSID0027301 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027301 TK.Half.Life NA 2.017 hours 1compartment NA NA Rat Human -DTXSID0027301 Css NA 0.08027 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027301 Css NA 0.6008 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027301 Css NA 0.07978 mg/L PBTK NA 50% Rat Human -DTXSID0027301 Css NA 0.3912 mg/L PBTK NA 95% Rat Human -DTXSID0027309 Clint NA 72.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027309 Fup NA 0.714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027309 Vd NA 0.9521 L/kg 1compartment NA NA Human Human +DTXSID0027301 TK.Half.Life NA 5.097 hours 1compartment NA NA Rat Human +DTXSID0027301 Css NA 0.01612 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027301 Css NA 0.1482 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027301 Css NA 0.01465 mg/L PBTK NA 50% Rat Human +DTXSID0027301 Css NA 0.1014 mg/L PBTK NA 95% Rat Human +DTXSID0027309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027309 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027309 Vd NA 1.234 L/kg 1compartment NA NA Human Human DTXSID0027309 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027309 TK.Half.Life NA 0.6273 hours 1compartment NA NA Human Human -DTXSID0027309 Css NA 0.009193 mg/L 3compartmentss NA 50% Human Human -DTXSID0027309 Css NA 0.09997 mg/L 3compartmentss NA 95% Human Human -DTXSID0027309 Css NA 0.007739 mg/L PBTK NA 50% Human Human -DTXSID0027309 Css NA 0.07062 mg/L PBTK NA 95% Human Human -DTXSID0027309 Clint NA 72.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027309 Fup NA 0.714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027309 Vd NA 0.9219 L/kg 1compartment NA NA Rat Human +DTXSID0027309 TK.Half.Life NA 1.049 hours 1compartment NA NA Human Human +DTXSID0027309 Css NA 0.02946 mg/L 3compartmentss NA 50% Human Human +DTXSID0027309 Css NA 0.3475 mg/L 3compartmentss NA 95% Human Human +DTXSID0027309 Css NA 0.02544 mg/L PBTK NA 50% Human Human +DTXSID0027309 Css NA 0.2408 mg/L PBTK NA 95% Human Human +DTXSID0027309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027309 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027309 Vd NA 1.116 L/kg 1compartment NA NA Rat Human DTXSID0027309 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027309 TK.Half.Life NA 0.2756 hours 1compartment NA NA Rat Human -DTXSID0027309 Css NA 0.004798 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027309 Css NA 0.04706 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027309 Css NA 0.003979 mg/L PBTK NA 50% Rat Human -DTXSID0027309 Css NA 0.03114 mg/L PBTK NA 95% Rat Human -DTXSID00274148 Clint NA 1.147 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID00274148 Fup NA 0.6087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID00274148 Vd NA 0.6345 L/kg 1compartment NA NA Human Human +DTXSID0027309 TK.Half.Life NA 0.4612 hours 1compartment NA NA Rat Human +DTXSID0027309 Css NA 0.003596 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027309 Css NA 0.03548 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027309 Css NA 0.003153 mg/L PBTK NA 50% Rat Human +DTXSID0027309 Css NA 0.02431 mg/L PBTK NA 95% Rat Human +DTXSID00274148 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00274148 Fup 0.766 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00274148 Vd NA 0.7519 L/kg 1compartment NA NA Human Human DTXSID00274148 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID00274148 TK.Half.Life NA 2.389 hours 1compartment NA NA Human Human -DTXSID00274148 Css NA 0.4052 mg/L 3compartmentss NA 50% Human Human -DTXSID00274148 Css NA 2.867 mg/L 3compartmentss NA 95% Human Human -DTXSID00274148 Css NA 0.3217 mg/L PBTK NA 50% Human Human -DTXSID00274148 Css NA 1.826 mg/L PBTK NA 95% Human Human -DTXSID00274148 Clint NA 1.147 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID00274148 Fup NA 0.6087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID00274148 Vd NA 0.6565 L/kg 1compartment NA NA Rat Human +DTXSID00274148 TK.Half.Life NA 6.348 hours 1compartment NA NA Human Human +DTXSID00274148 Css NA 0.544 mg/L 3compartmentss NA 50% Human Human +DTXSID00274148 Css NA 3.711 mg/L 3compartmentss NA 95% Human Human +DTXSID00274148 Css NA 0.4568 mg/L PBTK NA 50% Human Human +DTXSID00274148 Css NA 2.425 mg/L PBTK NA 95% Human Human +DTXSID00274148 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00274148 Fup 0.766 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00274148 Vd NA 0.7763 L/kg 1compartment NA NA Rat Human DTXSID00274148 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID00274148 TK.Half.Life NA 1.234 hours 1compartment NA NA Rat Human -DTXSID00274148 Css NA 0.1635 mg/L 3compartmentss NA 50% Rat Human -DTXSID00274148 Css NA 1.094 mg/L 3compartmentss NA 95% Rat Human -DTXSID00274148 Css NA 0.1259 mg/L PBTK NA 50% Rat Human -DTXSID00274148 Css NA 0.6405 mg/L PBTK NA 95% Rat Human -DTXSID0027432 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027432 Fup NA 0.7947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027432 Vd NA 1.395 L/kg 1compartment NA NA Human Human +DTXSID00274148 TK.Half.Life NA 2.235 hours 1compartment NA NA Rat Human +DTXSID00274148 Css NA 0.002759 mg/L 3compartmentss NA 50% Rat Human +DTXSID00274148 Css NA 0.01947 mg/L 3compartmentss NA 95% Rat Human +DTXSID00274148 Css NA 0.002259 mg/L PBTK NA 50% Rat Human +DTXSID00274148 Css NA 0.01228 mg/L PBTK NA 95% Rat Human +DTXSID0027432 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027432 Fup 0.673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027432 Vd NA 1.134 L/kg 1compartment NA NA Human Human DTXSID0027432 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0027432 TK.Half.Life NA 11.39 hours 1compartment NA NA Human Human -DTXSID0027432 Css NA 0.8986 mg/L 3compartmentss NA 50% Human Human -DTXSID0027432 Css NA 5.732 mg/L 3compartmentss NA 95% Human Human -DTXSID0027432 Css NA 0.821 mg/L PBTK NA 50% Human Human -DTXSID0027432 Css NA 3.784 mg/L PBTK NA 95% Human Human -DTXSID0027432 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027432 Fup NA 0.7947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027432 Vd NA 1.413 L/kg 1compartment NA NA Rat Human +DTXSID0027432 TK.Half.Life NA 10.91 hours 1compartment NA NA Human Human +DTXSID0027432 Css NA 0.891 mg/L 3compartmentss NA 50% Human Human +DTXSID0027432 Css NA 6.207 mg/L 3compartmentss NA 95% Human Human +DTXSID0027432 Css NA 0.7714 mg/L PBTK NA 50% Human Human +DTXSID0027432 Css NA 3.99 mg/L PBTK NA 95% Human Human +DTXSID0027432 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027432 Fup 0.673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027432 Vd NA 1.151 L/kg 1compartment NA NA Rat Human DTXSID0027432 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027432 TK.Half.Life NA 3.925 hours 1compartment NA NA Rat Human -DTXSID0027432 Css NA 0.2278 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027432 Css NA 1.457 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027432 Css NA 0.2037 mg/L PBTK NA 50% Rat Human -DTXSID0027432 Css NA 0.9035 mg/L PBTK NA 95% Rat Human -DTXSID0027436 Clint NA 0.04687 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027436 Fup NA 0.4117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027436 Vd NA 0.5591 L/kg 1compartment NA NA Human Human +DTXSID0027432 TK.Half.Life NA 3.771 hours 1compartment NA NA Rat Human +DTXSID0027432 Css NA 0.01691 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027432 Css NA 0.1476 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027432 Css NA 0.0141 mg/L PBTK NA 50% Rat Human +DTXSID0027432 Css NA 0.09632 mg/L PBTK NA 95% Rat Human +DTXSID0027436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027436 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027436 Vd NA 0.553 L/kg 1compartment NA NA Human Human DTXSID0027436 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027436 TK.Half.Life NA 8.136 hours 1compartment NA NA Human Human -DTXSID0027436 Css NA 1.576 mg/L 3compartmentss NA 50% Human Human -DTXSID0027436 Css NA 7.317 mg/L 3compartmentss NA 95% Human Human -DTXSID0027436 Css NA 1.188 mg/L PBTK NA 50% Human Human -DTXSID0027436 Css NA 4.667 mg/L PBTK NA 95% Human Human -DTXSID0027436 Clint NA 0.04687 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027436 Fup NA 0.4117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027436 Vd NA 0.5696 L/kg 1compartment NA NA Rat Human +DTXSID0027436 TK.Half.Life NA 8.922 hours 1compartment NA NA Human Human +DTXSID0027436 Css NA 1.728 mg/L 3compartmentss NA 50% Human Human +DTXSID0027436 Css NA 7.782 mg/L 3compartmentss NA 95% Human Human +DTXSID0027436 Css NA 1.293 mg/L PBTK NA 50% Human Human +DTXSID0027436 Css NA 5.033 mg/L PBTK NA 95% Human Human +DTXSID0027436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027436 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027436 Vd NA 0.5631 L/kg 1compartment NA NA Rat Human DTXSID0027436 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027436 TK.Half.Life NA 2.936 hours 1compartment NA NA Rat Human -DTXSID0027436 Css NA 0.4521 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027436 Css NA 1.842 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027436 Css NA 0.3259 mg/L PBTK NA 50% Rat Human -DTXSID0027436 Css NA 1.094 mg/L PBTK NA 95% Rat Human -DTXSID0027438 Clint NA 8.281 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027438 Fup NA 0.5582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027438 Vd NA 1.252 L/kg 1compartment NA NA Human Human -DTXSID0027438 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027438 TK.Half.Life NA 1.742 hours 1compartment NA NA Human Human -DTXSID0027438 Css NA 0.0968 mg/L 3compartmentss NA 50% Human Human -DTXSID0027438 Css NA 0.8902 mg/L 3compartmentss NA 95% Human Human -DTXSID0027438 Css NA 0.0805 mg/L PBTK NA 50% Human Human -DTXSID0027438 Css NA 0.6158 mg/L PBTK NA 95% Human Human -DTXSID0027438 Clint NA 8.281 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027438 Fup NA 0.5582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027438 Vd NA 1.107 L/kg 1compartment NA NA Rat Human +DTXSID0027436 TK.Half.Life NA 3.096 hours 1compartment NA NA Rat Human +DTXSID0027436 Css NA 0.11 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027436 Css NA 0.4289 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027436 Css NA 0.08158 mg/L PBTK NA 50% Rat Human +DTXSID0027436 Css NA 0.2641 mg/L PBTK NA 95% Rat Human +DTXSID0027438 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027438 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027438 Vd NA 1.027 L/kg 1compartment NA NA Human Human +DTXSID0027438 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0027438 TK.Half.Life NA 14.95 hours 1compartment NA NA Human Human +DTXSID0027438 Css NA 1.465 mg/L 3compartmentss NA 50% Human Human +DTXSID0027438 Css NA 7.201 mg/L 3compartmentss NA 95% Human Human +DTXSID0027438 Css NA 1.187 mg/L PBTK NA 50% Human Human +DTXSID0027438 Css NA 4.684 mg/L PBTK NA 95% Human Human +DTXSID0027438 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027438 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027438 Vd NA 0.926 L/kg 1compartment NA NA Rat Human DTXSID0027438 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027438 TK.Half.Life NA 0.7971 hours 1compartment NA NA Rat Human -DTXSID0027438 Css NA 0.04781 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027438 Css NA 0.3774 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027438 Css NA 0.03904 mg/L PBTK NA 50% Rat Human -DTXSID0027438 Css NA 0.2362 mg/L PBTK NA 95% Rat Human -DTXSID0027486 Clint NA 0.09361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027486 Fup NA 0.5658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027486 Vd NA 0.9713 L/kg 1compartment NA NA Human Human -DTXSID0027486 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0027486 TK.Half.Life NA 9.993 hours 1compartment NA NA Human Human -DTXSID0027486 Css NA 1.074 mg/L 3compartmentss NA 50% Human Human -DTXSID0027486 Css NA 7.381 mg/L 3compartmentss NA 95% Human Human -DTXSID0027486 Css NA 0.8895 mg/L PBTK NA 50% Human Human -DTXSID0027486 Css NA 4.734 mg/L PBTK NA 95% Human Human -DTXSID0027486 Clint NA 0.09361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027486 Fup NA 0.5658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027486 Vd NA 0.9069 L/kg 1compartment NA NA Rat Human +DTXSID0027438 TK.Half.Life NA 4.381 hours 1compartment NA NA Rat Human +DTXSID0027438 Css NA 0.09256 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027438 Css NA 0.3918 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027438 Css NA 0.07456 mg/L PBTK NA 50% Rat Human +DTXSID0027438 Css NA 0.2483 mg/L PBTK NA 95% Rat Human +DTXSID0027486 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027486 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027486 Vd NA 0.6454 L/kg 1compartment NA NA Human Human +DTXSID0027486 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0027486 TK.Half.Life NA 8.514 hours 1compartment NA NA Human Human +DTXSID0027486 Css NA 1.229 mg/L 3compartmentss NA 50% Human Human +DTXSID0027486 Css NA 6.245 mg/L 3compartmentss NA 95% Human Human +DTXSID0027486 Css NA 0.9487 mg/L PBTK NA 50% Human Human +DTXSID0027486 Css NA 4.042 mg/L PBTK NA 95% Human Human +DTXSID0027486 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027486 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027486 Vd NA 0.6464 L/kg 1compartment NA NA Rat Human DTXSID0027486 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027486 TK.Half.Life NA 3.315 hours 1compartment NA NA Rat Human -DTXSID0027486 Css NA 0.3118 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027486 Css NA 2.105 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027486 Css NA 0.2498 mg/L PBTK NA 50% Rat Human -DTXSID0027486 Css NA 1.245 mg/L PBTK NA 95% Rat Human +DTXSID0027486 TK.Half.Life NA 2.894 hours 1compartment NA NA Rat Human +DTXSID0027486 Css NA 0.02325 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027486 Css NA 0.1595 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027486 Css NA 0.01727 mg/L PBTK NA 50% Rat Human +DTXSID0027486 Css NA 0.1027 mg/L PBTK NA 95% Rat Human DTXSID0027513 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0027513 Fup NA 0.5424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027513 Vd NA 0.598 L/kg 1compartment NA NA Human Human +DTXSID0027513 Vd NA 0.5302 L/kg 1compartment NA NA Human Human DTXSID0027513 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027513 TK.Half.Life NA 7.133 hours 1compartment NA NA Human Human -DTXSID0027513 Css NA 1.376 mg/L 3compartmentss NA 50% Human Human -DTXSID0027513 Css NA 8.384 mg/L 3compartmentss NA 95% Human Human -DTXSID0027513 Css NA 1.064 mg/L PBTK NA 50% Human Human -DTXSID0027513 Css NA 5.292 mg/L PBTK NA 95% Human Human +DTXSID0027513 TK.Half.Life NA 6.324 hours 1compartment NA NA Human Human +DTXSID0027513 Css NA 1.175 mg/L 3compartmentss NA 50% Human Human +DTXSID0027513 Css NA 7.45 mg/L 3compartmentss NA 95% Human Human +DTXSID0027513 Css NA 0.8981 mg/L PBTK NA 50% Human Human +DTXSID0027513 Css NA 4.643 mg/L PBTK NA 95% Human Human DTXSID0027513 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0027513 Fup NA 0.5424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027513 Vd NA 0.6177 L/kg 1compartment NA NA Rat Human +DTXSID0027513 Vd NA 0.5569 L/kg 1compartment NA NA Rat Human DTXSID0027513 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027513 TK.Half.Life NA 2.511 hours 1compartment NA NA Rat Human -DTXSID0027513 Css NA 0.3632 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027513 Css NA 2.021 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027513 Css NA 0.2704 mg/L PBTK NA 50% Rat Human -DTXSID0027513 Css NA 1.185 mg/L PBTK NA 95% Rat Human -DTXSID0027561 Clint NA 273.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027561 Fup NA 0.5818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027561 Vd NA 1.054 L/kg 1compartment NA NA Human Human -DTXSID0027561 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027561 TK.Half.Life NA 0.6809 hours 1compartment NA NA Human Human -DTXSID0027561 Css NA 0.002928 mg/L 3compartmentss NA 50% Human Human -DTXSID0027561 Css NA 0.03248 mg/L 3compartmentss NA 95% Human Human -DTXSID0027561 Css NA 0.002448 mg/L PBTK NA 50% Human Human -DTXSID0027561 Css NA 0.02289 mg/L PBTK NA 95% Human Human -DTXSID0027561 Clint NA 273.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027561 Fup NA 0.5818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027561 Vd NA 0.9706 L/kg 1compartment NA NA Rat Human +DTXSID0027513 TK.Half.Life NA 2.264 hours 1compartment NA NA Rat Human +DTXSID0027513 Css NA 0.02236 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027513 Css NA 0.1745 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027513 Css NA 0.0164 mg/L PBTK NA 50% Rat Human +DTXSID0027513 Css NA 0.1092 mg/L PBTK NA 95% Rat Human +DTXSID0027561 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027561 Fup 0.461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027561 Vd NA 1.079 L/kg 1compartment NA NA Human Human +DTXSID0027561 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0027561 TK.Half.Life NA 16.34 hours 1compartment NA NA Human Human +DTXSID0027561 Css NA 1.514 mg/L 3compartmentss NA 50% Human Human +DTXSID0027561 Css NA 7.297 mg/L 3compartmentss NA 95% Human Human +DTXSID0027561 Css NA 1.23 mg/L PBTK NA 50% Human Human +DTXSID0027561 Css NA 4.842 mg/L PBTK NA 95% Human Human +DTXSID0027561 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027561 Fup 0.461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027561 Vd NA 0.96 L/kg 1compartment NA NA Rat Human DTXSID0027561 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027561 TK.Half.Life NA 0.2748 hours 1compartment NA NA Rat Human -DTXSID0027561 Css NA 0.001559 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027561 Css NA 0.0167 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027561 Css NA 0.00127 mg/L PBTK NA 50% Rat Human -DTXSID0027561 Css NA 0.01114 mg/L PBTK NA 95% Rat Human +DTXSID0027561 TK.Half.Life NA 4.677 hours 1compartment NA NA Rat Human +DTXSID0027561 Css NA 0.09494 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027561 Css NA 0.4151 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027561 Css NA 0.07668 mg/L PBTK NA 50% Rat Human +DTXSID0027561 Css NA 0.2624 mg/L PBTK NA 95% Rat Human DTXSID0027565 Clint NA 3.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0027565 Fup NA 0.7477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027565 Vd NA 1.209 L/kg 1compartment NA NA Human Human +DTXSID0027565 Vd NA 1.223 L/kg 1compartment NA NA Human Human DTXSID0027565 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027565 TK.Half.Life NA 2.245 hours 1compartment NA NA Human Human -DTXSID0027565 Css NA 0.1667 mg/L 3compartmentss NA 50% Human Human -DTXSID0027565 Css NA 1.24 mg/L 3compartmentss NA 95% Human Human -DTXSID0027565 Css NA 0.1456 mg/L PBTK NA 50% Human Human -DTXSID0027565 Css NA 0.8688 mg/L PBTK NA 95% Human Human +DTXSID0027565 TK.Half.Life NA 2.276 hours 1compartment NA NA Human Human +DTXSID0027565 Css NA 0.1604 mg/L 3compartmentss NA 50% Human Human +DTXSID0027565 Css NA 1.21 mg/L 3compartmentss NA 95% Human Human +DTXSID0027565 Css NA 0.1408 mg/L PBTK NA 50% Human Human +DTXSID0027565 Css NA 0.8364 mg/L PBTK NA 95% Human Human DTXSID0027565 Clint NA 3.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0027565 Fup NA 0.7477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027565 Vd NA 1.119 L/kg 1compartment NA NA Rat Human +DTXSID0027565 Vd NA 1.128 L/kg 1compartment NA NA Rat Human DTXSID0027565 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027565 TK.Half.Life NA 1.076 hours 1compartment NA NA Rat Human -DTXSID0027565 Css NA 0.0732 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027565 Css NA 0.5514 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027565 Css NA 0.06366 mg/L PBTK NA 50% Rat Human -DTXSID0027565 Css NA 0.3382 mg/L PBTK NA 95% Rat Human +DTXSID0027565 TK.Half.Life NA 1.085 hours 1compartment NA NA Rat Human +DTXSID0027565 Css NA 0.01628 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027565 Css NA 0.1201 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027565 Css NA 0.01474 mg/L PBTK NA 50% Rat Human +DTXSID0027565 Css NA 0.07725 mg/L PBTK NA 95% Rat Human DTXSID0027567 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0027567 Fup NA 0.4673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027567 Vd NA 2.273 L/kg 1compartment NA NA Human Human -DTXSID0027567 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID0027567 TK.Half.Life NA 61.72 hours 1compartment NA NA Human Human -DTXSID0027567 Css NA 2.784 mg/L 3compartmentss NA 50% Human Human -DTXSID0027567 Css NA 10.46 mg/L 3compartmentss NA 95% Human Human -DTXSID0027567 Css NA 2.272 mg/L PBTK NA 50% Human Human -DTXSID0027567 Css NA 7.182 mg/L PBTK NA 95% Human Human +DTXSID0027567 Vd NA 1.838 L/kg 1compartment NA NA Human Human +DTXSID0027567 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID0027567 TK.Half.Life NA 36.64 hours 1compartment NA NA Human Human +DTXSID0027567 Css NA 1.961 mg/L 3compartmentss NA 50% Human Human +DTXSID0027567 Css NA 8.287 mg/L 3compartmentss NA 95% Human Human +DTXSID0027567 Css NA 1.627 mg/L PBTK NA 50% Human Human +DTXSID0027567 Css NA 5.632 mg/L PBTK NA 95% Human Human DTXSID0027567 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0027567 Fup NA 0.4673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027567 Vd NA 1.797 L/kg 1compartment NA NA Rat Human -DTXSID0027567 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0027567 TK.Half.Life NA 10.42 hours 1compartment NA NA Rat Human -DTXSID0027567 Css NA 0.7501 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027567 Css NA 2.384 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027567 Css NA 0.5914 mg/L PBTK NA 50% Rat Human -DTXSID0027567 Css NA 1.518 mg/L PBTK NA 95% Rat Human +DTXSID0027567 Vd NA 1.496 L/kg 1compartment NA NA Rat Human +DTXSID0027567 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0027567 TK.Half.Life NA 7.797 hours 1compartment NA NA Rat Human +DTXSID0027567 Css NA 0.1225 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027567 Css NA 0.4597 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027567 Css NA 0.1017 mg/L PBTK NA 50% Rat Human +DTXSID0027567 Css NA 0.2993 mg/L PBTK NA 95% Rat Human DTXSID0027640 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0027640 Fup NA 0.6768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0027640 Vd NA 0.5837 L/kg 1compartment NA NA Human Human DTXSID0027640 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0027640 TK.Half.Life NA 5.581 hours 1compartment NA NA Human Human -DTXSID0027640 Css NA 1.148 mg/L 3compartmentss NA 50% Human Human -DTXSID0027640 Css NA 7.122 mg/L 3compartmentss NA 95% Human Human -DTXSID0027640 Css NA 0.8982 mg/L PBTK NA 50% Human Human -DTXSID0027640 Css NA 4.498 mg/L PBTK NA 95% Human Human +DTXSID0027640 Css NA 0.9763 mg/L 3compartmentss NA 50% Human Human +DTXSID0027640 Css NA 6.369 mg/L 3compartmentss NA 95% Human Human +DTXSID0027640 Css NA 0.7662 mg/L PBTK NA 50% Human Human +DTXSID0027640 Css NA 3.997 mg/L PBTK NA 95% Human Human DTXSID0027640 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0027640 Fup NA 0.6768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0027640 Vd NA 0.6167 L/kg 1compartment NA NA Rat Human DTXSID0027640 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0027640 TK.Half.Life NA 2.009 hours 1compartment NA NA Rat Human -DTXSID0027640 Css NA 0.3008 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027640 Css NA 1.817 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027640 Css NA 0.2265 mg/L PBTK NA 50% Rat Human -DTXSID0027640 Css NA 1.064 mg/L PBTK NA 95% Rat Human +DTXSID0027640 Css NA 0.01859 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027640 Css NA 0.1537 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027640 Css NA 0.01405 mg/L PBTK NA 50% Rat Human +DTXSID0027640 Css NA 0.09555 mg/L PBTK NA 95% Rat Human DTXSID0027721 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0027721 Fup 3.09e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0027721 Vd NA 922.2 L/kg 1compartment NA NA Human Human -DTXSID0027721 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID0027721 TK.Half.Life NA 57760000 hours 1compartment NA NA Human Human -DTXSID0027721 Css NA 29.36 mg/L 3compartmentss NA 50% Human Human -DTXSID0027721 Css NA 60.99 mg/L 3compartmentss NA 95% Human Human -DTXSID0027721 Css NA 4608 mg/L PBTK NA 50% Human Human -DTXSID0027721 Css NA 9150 mg/L PBTK NA 95% Human Human +DTXSID0027721 Vd NA 62.68 L/kg 1compartment NA NA Human Human +DTXSID0027721 Days.Css NA 11150 Days PBTK NA NA Human Human +DTXSID0027721 TK.Half.Life NA 4053000 hours 1compartment NA NA Human Human +DTXSID0027721 Css NA 523.2 mg/L 3compartmentss NA 50% Human Human +DTXSID0027721 Css NA 1125 mg/L 3compartmentss NA 95% Human Human +DTXSID0027721 Css NA 3972 mg/L PBTK NA 50% Human Human +DTXSID0027721 Css NA 8250 mg/L PBTK NA 95% Human Human DTXSID0027721 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0027721 Fup 3.09e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0027721 Vd NA 843.7 L/kg 1compartment NA NA Rat Human -DTXSID0027721 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID0027721 TK.Half.Life NA 18730000 hours 1compartment NA NA Rat Human -DTXSID0027721 Css NA 8.077 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027721 Css NA 8.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027721 Css NA 1325 mg/L PBTK NA 50% Rat Human -DTXSID0027721 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID0027729 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027729 Fup NA 0.8565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027729 Vd NA 1.055 L/kg 1compartment NA NA Human Human -DTXSID0027729 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027729 TK.Half.Life NA 8.182 hours 1compartment NA NA Human Human -DTXSID0027729 Css NA 0.9004 mg/L 3compartmentss NA 50% Human Human -DTXSID0027729 Css NA 5.528 mg/L 3compartmentss NA 95% Human Human -DTXSID0027729 Css NA 0.7967 mg/L PBTK NA 50% Human Human -DTXSID0027729 Css NA 3.671 mg/L PBTK NA 95% Human Human -DTXSID0027729 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027729 Fup NA 0.8565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027729 Vd NA 1.025 L/kg 1compartment NA NA Rat Human -DTXSID0027729 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027729 TK.Half.Life NA 2.655 hours 1compartment NA NA Rat Human -DTXSID0027729 Css NA 0.2287 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027729 Css NA 1.453 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027729 Css NA 0.1972 mg/L PBTK NA 50% Rat Human -DTXSID0027729 Css NA 0.8884 mg/L PBTK NA 95% Rat Human -DTXSID0027771 Clint NA 8.326 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027771 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027771 Vd NA 3.097 L/kg 1compartment NA NA Human Human -DTXSID0027771 Days.Css NA 44 Days PBTK NA NA Human Human -DTXSID0027771 TK.Half.Life NA 216.5 hours 1compartment NA NA Human Human -DTXSID0027771 Css NA 8.77 mg/L 3compartmentss NA 50% Human Human -DTXSID0027771 Css NA 54.52 mg/L 3compartmentss NA 95% Human Human -DTXSID0027771 Css NA 6.025 mg/L PBTK NA 50% Human Human -DTXSID0027771 Css NA 36.35 mg/L PBTK NA 95% Human Human -DTXSID0027771 Clint NA 8.326 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027771 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027771 Vd NA 2.319 L/kg 1compartment NA NA Rat Human -DTXSID0027771 Days.Css NA 24 Days PBTK NA NA Rat Human -DTXSID0027771 TK.Half.Life NA 29.31 hours 1compartment NA NA Rat Human -DTXSID0027771 Css NA 4.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027771 Css NA 23.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027771 Css NA 3.239 mg/L PBTK NA 50% Rat Human -DTXSID0027771 Css NA 14.82 mg/L PBTK NA 95% Rat Human -DTXSID0027773 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027773 Fup NA 0.2227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027773 Vd NA 2.711 L/kg 1compartment NA NA Human Human -DTXSID0027773 Days.Css NA 72 Days PBTK NA NA Human Human -DTXSID0027773 TK.Half.Life NA 322.7 hours 1compartment NA NA Human Human -DTXSID0027773 Css NA 13.25 mg/L 3compartmentss NA 50% Human Human -DTXSID0027773 Css NA 38.04 mg/L 3compartmentss NA 95% Human Human -DTXSID0027773 Css NA 9.645 mg/L PBTK NA 50% Human Human -DTXSID0027773 Css NA 25.34 mg/L PBTK NA 95% Human Human -DTXSID0027773 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027773 Fup NA 0.2227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027773 Vd NA 2.059 L/kg 1compartment NA NA Rat Human -DTXSID0027773 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID0027773 TK.Half.Life NA 35.44 hours 1compartment NA NA Rat Human -DTXSID0027773 Css NA 3.572 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027773 Css NA 8.497 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027773 Css NA 2.5 mg/L PBTK NA 50% Rat Human -DTXSID0027773 Css NA 5.237 mg/L PBTK NA 95% Rat Human -DTXSID0027802 Clint NA 98.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027802 Fup NA 0.0365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027802 Vd NA 1.569 L/kg 1compartment NA NA Human Human -DTXSID0027802 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027802 TK.Half.Life NA 3.194 hours 1compartment NA NA Human Human -DTXSID0027802 Css NA 0.2038 mg/L 3compartmentss NA 50% Human Human -DTXSID0027802 Css NA 1.666 mg/L 3compartmentss NA 95% Human Human -DTXSID0027802 Css NA 0.1294 mg/L PBTK NA 50% Human Human -DTXSID0027802 Css NA 1.012 mg/L PBTK NA 95% Human Human -DTXSID0027802 Clint NA 98.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027802 Fup NA 0.0365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027802 Vd NA 1.172 L/kg 1compartment NA NA Rat Human -DTXSID0027802 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027802 TK.Half.Life NA 1.163 hours 1compartment NA NA Rat Human -DTXSID0027802 Css NA 0.117 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027802 Css NA 0.7676 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027802 Css NA 0.0697 mg/L PBTK NA 50% Rat Human -DTXSID0027802 Css NA 0.4499 mg/L PBTK NA 95% Rat Human +DTXSID0027721 Vd NA 53.3 L/kg 1compartment NA NA Rat Human +DTXSID0027721 Days.Css NA 11150 Days PBTK NA NA Rat Human +DTXSID0027721 TK.Half.Life NA 1175000 hours 1compartment NA NA Rat Human +DTXSID0027721 Css NA 10.08 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027721 Css NA 37.52 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027721 Css NA 87.7 mg/L PBTK NA 50% Rat Human +DTXSID0027721 Css NA 304.8 mg/L PBTK NA 95% Rat Human +DTXSID0027771 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027771 Fup 0.0159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027771 Vd NA 2.071 L/kg 1compartment NA NA Human Human +DTXSID0027771 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0027771 TK.Half.Life NA 24.92 hours 1compartment NA NA Human Human +DTXSID0027771 Css NA 1.803 mg/L 3compartmentss NA 50% Human Human +DTXSID0027771 Css NA 14.15 mg/L 3compartmentss NA 95% Human Human +DTXSID0027771 Css NA 1.16 mg/L PBTK NA 50% Human Human +DTXSID0027771 Css NA 8.733 mg/L PBTK NA 95% Human Human +DTXSID0027771 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027771 Fup 0.0159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027771 Vd NA 1.539 L/kg 1compartment NA NA Rat Human +DTXSID0027771 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0027771 TK.Half.Life NA 7.759 hours 1compartment NA NA Rat Human +DTXSID0027771 Css NA 0.2308 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027771 Css NA 1.563 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027771 Css NA 0.1444 mg/L PBTK NA 50% Rat Human +DTXSID0027771 Css NA 0.9487 mg/L PBTK NA 95% Rat Human +DTXSID0027773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027773 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027773 Vd NA 2.753 L/kg 1compartment NA NA Human Human +DTXSID0027773 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0027773 TK.Half.Life NA 8.403 hours 1compartment NA NA Human Human +DTXSID0027773 Css NA 0.2671 mg/L 3compartmentss NA 50% Human Human +DTXSID0027773 Css NA 1.688 mg/L 3compartmentss NA 95% Human Human +DTXSID0027773 Css NA 0.1942 mg/L PBTK NA 50% Human Human +DTXSID0027773 Css NA 1.177 mg/L PBTK NA 95% Human Human +DTXSID0027773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027773 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027773 Vd NA 2.092 L/kg 1compartment NA NA Rat Human +DTXSID0027773 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0027773 TK.Half.Life NA 2.007 hours 1compartment NA NA Rat Human +DTXSID0027773 Css NA 0.03422 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027773 Css NA 0.1676 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027773 Css NA 0.02477 mg/L PBTK NA 50% Rat Human +DTXSID0027773 Css NA 0.1163 mg/L PBTK NA 95% Rat Human +DTXSID0027802 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027802 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027802 Vd NA 1.744 L/kg 1compartment NA NA Human Human +DTXSID0027802 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0027802 TK.Half.Life NA 24.53 hours 1compartment NA NA Human Human +DTXSID0027802 Css NA 2.222 mg/L 3compartmentss NA 50% Human Human +DTXSID0027802 Css NA 18.77 mg/L 3compartmentss NA 95% Human Human +DTXSID0027802 Css NA 1.388 mg/L PBTK NA 50% Human Human +DTXSID0027802 Css NA 11.42 mg/L PBTK NA 95% Human Human +DTXSID0027802 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027802 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027802 Vd NA 1.29 L/kg 1compartment NA NA Rat Human +DTXSID0027802 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0027802 TK.Half.Life NA 8.707 hours 1compartment NA NA Rat Human +DTXSID0027802 Css NA 0.288 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027802 Css NA 2.098 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027802 Css NA 0.1763 mg/L PBTK NA 50% Rat Human +DTXSID0027802 Css NA 1.236 mg/L PBTK NA 95% Rat Human DTXSID0027804 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0027804 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0027804 Vd NA 1.21 L/kg 1compartment NA NA Human Human DTXSID0027804 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0027804 TK.Half.Life NA 7.838 hours 1compartment NA NA Human Human -DTXSID0027804 Css NA 0.7718 mg/L 3compartmentss NA 50% Human Human -DTXSID0027804 Css NA 5.37 mg/L 3compartmentss NA 95% Human Human -DTXSID0027804 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID0027804 Css NA 3.549 mg/L PBTK NA 95% Human Human +DTXSID0027804 Css NA 0.6539 mg/L 3compartmentss NA 50% Human Human +DTXSID0027804 Css NA 4.796 mg/L 3compartmentss NA 95% Human Human +DTXSID0027804 Css NA 0.5918 mg/L PBTK NA 50% Human Human +DTXSID0027804 Css NA 3.169 mg/L PBTK NA 95% Human Human DTXSID0027804 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0027804 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0027804 Vd NA 1.239 L/kg 1compartment NA NA Rat Human DTXSID0027804 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0027804 TK.Half.Life NA 2.732 hours 1compartment NA NA Rat Human -DTXSID0027804 Css NA 0.1928 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027804 Css NA 1.269 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027804 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID0027804 Css NA 0.7835 mg/L PBTK NA 95% Rat Human -DTXSID0027806 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027806 Fup NA 0.3828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027806 Vd NA 0.4158 L/kg 1compartment NA NA Human Human +DTXSID0027804 Css NA 0.01184 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027804 Css NA 0.09867 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027804 Css NA 0.01048 mg/L PBTK NA 50% Rat Human +DTXSID0027804 Css NA 0.06695 mg/L PBTK NA 95% Rat Human +DTXSID0027806 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027806 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027806 Vd NA 0.4115 L/kg 1compartment NA NA Human Human DTXSID0027806 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027806 TK.Half.Life NA 7.028 hours 1compartment NA NA Human Human -DTXSID0027806 Css NA 1.968 mg/L 3compartmentss NA 50% Human Human -DTXSID0027806 Css NA 8.439 mg/L 3compartmentss NA 95% Human Human -DTXSID0027806 Css NA 1.394 mg/L PBTK NA 50% Human Human -DTXSID0027806 Css NA 5.276 mg/L PBTK NA 95% Human Human -DTXSID0027806 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027806 Fup NA 0.3828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027806 Vd NA 0.4225 L/kg 1compartment NA NA Rat Human +DTXSID0027806 TK.Half.Life NA 7.216 hours 1compartment NA NA Human Human +DTXSID0027806 Css NA 1.983 mg/L 3compartmentss NA 50% Human Human +DTXSID0027806 Css NA 8.148 mg/L 3compartmentss NA 95% Human Human +DTXSID0027806 Css NA 1.398 mg/L PBTK NA 50% Human Human +DTXSID0027806 Css NA 5.086 mg/L PBTK NA 95% Human Human +DTXSID0027806 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027806 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027806 Vd NA 0.4252 L/kg 1compartment NA NA Rat Human DTXSID0027806 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027806 TK.Half.Life NA 2.435 hours 1compartment NA NA Rat Human -DTXSID0027806 Css NA 0.5432 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027806 Css NA 1.935 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027806 Css NA 0.3652 mg/L PBTK NA 50% Rat Human -DTXSID0027806 Css NA 1.128 mg/L PBTK NA 95% Rat Human -DTXSID0027852 Clint NA 10.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027852 Fup NA 0.1869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027852 Vd NA 2.602 L/kg 1compartment NA NA Human Human -DTXSID0027852 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027852 TK.Half.Life NA 13.75 hours 1compartment NA NA Human Human -DTXSID0027852 Css NA 0.5604 mg/L 3compartmentss NA 50% Human Human -DTXSID0027852 Css NA 3.194 mg/L 3compartmentss NA 95% Human Human -DTXSID0027852 Css NA 0.4022 mg/L PBTK NA 50% Human Human -DTXSID0027852 Css NA 2.228 mg/L PBTK NA 95% Human Human -DTXSID0027852 Clint NA 10.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027852 Fup NA 0.1869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027852 Vd NA 1.975 L/kg 1compartment NA NA Rat Human -DTXSID0027852 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027852 TK.Half.Life NA 3.371 hours 1compartment NA NA Rat Human -DTXSID0027852 Css NA 0.2996 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027852 Css NA 1.253 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027852 Css NA 0.2061 mg/L PBTK NA 50% Rat Human -DTXSID0027852 Css NA 0.8344 mg/L PBTK NA 95% Rat Human -DTXSID0027856 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027856 Fup NA 0.923 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027856 Vd NA 0.8428 L/kg 1compartment NA NA Human Human -DTXSID0027856 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027856 TK.Half.Life NA 5.929 hours 1compartment NA NA Human Human -DTXSID0027856 Css NA 0.8514 mg/L 3compartmentss NA 50% Human Human -DTXSID0027856 Css NA 3.116 mg/L 3compartmentss NA 95% Human Human -DTXSID0027856 Css NA 0.7245 mg/L PBTK NA 50% Human Human -DTXSID0027856 Css NA 2.235 mg/L PBTK NA 95% Human Human -DTXSID0027856 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027856 Fup NA 0.923 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027856 Vd NA 0.8635 L/kg 1compartment NA NA Rat Human -DTXSID0027856 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027856 TK.Half.Life NA 2.064 hours 1compartment NA NA Rat Human -DTXSID0027856 Css NA 0.2202 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027856 Css NA 0.7743 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027856 Css NA 0.1836 mg/L PBTK NA 50% Rat Human -DTXSID0027856 Css NA 0.5015 mg/L PBTK NA 95% Rat Human -DTXSID0027858 Clint NA 6.264 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027858 Fup NA 0.0604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027858 Vd NA 3.072 L/kg 1compartment NA NA Human Human -DTXSID0027858 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID0027858 TK.Half.Life NA 171.3 hours 1compartment NA NA Human Human -DTXSID0027858 Css NA 6.986 mg/L 3compartmentss NA 50% Human Human -DTXSID0027858 Css NA 41.92 mg/L 3compartmentss NA 95% Human Human -DTXSID0027858 Css NA 4.84 mg/L PBTK NA 50% Human Human -DTXSID0027858 Css NA 28.04 mg/L PBTK NA 95% Human Human -DTXSID0027858 Clint NA 6.264 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027858 Fup NA 0.0604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027858 Vd NA 2.302 L/kg 1compartment NA NA Rat Human -DTXSID0027858 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID0027858 TK.Half.Life NA 23.93 hours 1compartment NA NA Rat Human -DTXSID0027858 Css NA 3.822 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027858 Css NA 18.69 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027858 Css NA 2.537 mg/L PBTK NA 50% Rat Human -DTXSID0027858 Css NA 12.19 mg/L PBTK NA 95% Rat Human -DTXSID0027933 Clint NA 82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027933 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027933 Vd NA 100.2 L/kg 1compartment NA NA Human Human -DTXSID0027933 Days.Css NA 186 Days PBTK NA NA Human Human -DTXSID0027933 TK.Half.Life NA 796.1 hours 1compartment NA NA Human Human -DTXSID0027933 Css NA 0.05448 mg/L 3compartmentss NA 50% Human Human -DTXSID0027933 Css NA 0.3215 mg/L 3compartmentss NA 95% Human Human -DTXSID0027933 Css NA 0.657 mg/L PBTK NA 50% Human Human -DTXSID0027933 Css NA 3.562 mg/L PBTK NA 95% Human Human -DTXSID0027933 Clint NA 82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027933 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027933 Vd NA 86.58 L/kg 1compartment NA NA Rat Human -DTXSID0027933 Days.Css NA 122 Days PBTK NA NA Rat Human -DTXSID0027933 TK.Half.Life NA 124.5 hours 1compartment NA NA Rat Human -DTXSID0027933 Css NA 0.02796 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027933 Css NA 0.119 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027933 Css NA 0.3578 mg/L PBTK NA 50% Rat Human -DTXSID0027933 Css NA 1.453 mg/L PBTK NA 95% Rat Human -DTXSID0027981 Clint NA 0.5318 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027981 Fup NA 0.0922 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0027981 Vd NA 0.2697 L/kg 1compartment NA NA Human Human +DTXSID0027806 TK.Half.Life NA 2.541 hours 1compartment NA NA Rat Human +DTXSID0027806 Css NA 0.1279 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027806 Css NA 0.444 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027806 Css NA 0.08828 mg/L PBTK NA 50% Rat Human +DTXSID0027806 Css NA 0.2674 mg/L PBTK NA 95% Rat Human +DTXSID0027981 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027981 Fup 0.501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0027981 Vd NA 1.147 L/kg 1compartment NA NA Human Human DTXSID0027981 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0027981 TK.Half.Life NA 10.11 hours 1compartment NA NA Human Human -DTXSID0027981 Css NA 5.948 mg/L 3compartmentss NA 50% Human Human -DTXSID0027981 Css NA 28.89 mg/L 3compartmentss NA 95% Human Human -DTXSID0027981 Css NA 3.636 mg/L PBTK NA 50% Human Human -DTXSID0027981 Css NA 16.86 mg/L PBTK NA 95% Human Human -DTXSID0027981 Clint NA 0.5318 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027981 Fup NA 0.0922 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0027981 Vd NA 0.259 L/kg 1compartment NA NA Rat Human +DTXSID0027981 TK.Half.Life NA 16.14 hours 1compartment NA NA Human Human +DTXSID0027981 Css NA 1.42 mg/L 3compartmentss NA 50% Human Human +DTXSID0027981 Css NA 7.494 mg/L 3compartmentss NA 95% Human Human +DTXSID0027981 Css NA 1.17 mg/L PBTK NA 50% Human Human +DTXSID0027981 Css NA 4.928 mg/L PBTK NA 95% Human Human +DTXSID0027981 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027981 Fup 0.501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0027981 Vd NA 1.018 L/kg 1compartment NA NA Rat Human DTXSID0027981 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027981 TK.Half.Life NA 4.343 hours 1compartment NA NA Rat Human -DTXSID0027981 Css NA 2.243 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027981 Css NA 9.026 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027981 Css NA 1.276 mg/L PBTK NA 50% Rat Human -DTXSID0027981 Css NA 4.935 mg/L PBTK NA 95% Rat Human -DTXSID0027983 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID0027983 Fup 0.8901 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID0027983 Vd NA 0.9499 L/kg 1compartment NA NA Human Human -DTXSID0027983 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0027983 TK.Half.Life NA 6.988 hours 1compartment NA NA Human Human -DTXSID0027983 Css NA 0.8917 mg/L 3compartmentss NA 50% Human Human -DTXSID0027983 Css NA 5.068 mg/L 3compartmentss NA 95% Human Human -DTXSID0027983 Css NA 0.7718 mg/L PBTK NA 50% Human Human -DTXSID0027983 Css NA 3.37 mg/L PBTK NA 95% Human Human -DTXSID0027983 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID0027983 Fup 0.8901 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID0027983 Vd NA 0.9483 L/kg 1compartment NA NA Rat Human -DTXSID0027983 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0027983 TK.Half.Life NA 2.356 hours 1compartment NA NA Rat Human -DTXSID0027983 Css NA 0.227 mg/L 3compartmentss NA 50% Rat Human -DTXSID0027983 Css NA 1.345 mg/L 3compartmentss NA 95% Rat Human -DTXSID0027983 Css NA 0.1922 mg/L PBTK NA 50% Rat Human -DTXSID0027983 Css NA 0.8228 mg/L PBTK NA 95% Rat Human -DTXSID0028030 Clint NA 3190 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0028030 Fup NA 0.0539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0028030 Vd NA 3.407 L/kg 1compartment NA NA Human Human +DTXSID0027981 TK.Half.Life NA 4.575 hours 1compartment NA NA Rat Human +DTXSID0027981 Css NA 0.08814 mg/L 3compartmentss NA 50% Rat Human +DTXSID0027981 Css NA 0.4095 mg/L 3compartmentss NA 95% Rat Human +DTXSID0027981 Css NA 0.07254 mg/L PBTK NA 50% Rat Human +DTXSID0027981 Css NA 0.2595 mg/L PBTK NA 95% Rat Human +DTXSID0028030 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0028030 Fup 0.04 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0028030 Vd NA 3.237 L/kg 1compartment NA NA Human Human DTXSID0028030 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0028030 TK.Half.Life NA 2.511 hours 1compartment NA NA Human Human -DTXSID0028030 Css NA 0.0006854 mg/L 3compartmentss NA 50% Human Human -DTXSID0028030 Css NA 0.004478 mg/L 3compartmentss NA 95% Human Human -DTXSID0028030 Css NA 0.000521 mg/L PBTK NA 50% Human Human -DTXSID0028030 Css NA 0.003211 mg/L PBTK NA 95% Human Human -DTXSID0028030 Clint NA 3190 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0028030 Fup NA 0.0539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0028030 Vd NA 2.721 L/kg 1compartment NA NA Rat Human +DTXSID0028030 TK.Half.Life NA 5.283 hours 1compartment NA NA Human Human +DTXSID0028030 Css NA 0.1168 mg/L 3compartmentss NA 50% Human Human +DTXSID0028030 Css NA 0.9953 mg/L 3compartmentss NA 95% Human Human +DTXSID0028030 Css NA 0.0916 mg/L PBTK NA 50% Human Human +DTXSID0028030 Css NA 0.7235 mg/L PBTK NA 95% Human Human +DTXSID0028030 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0028030 Fup 0.04 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0028030 Vd NA 2.713 L/kg 1compartment NA NA Rat Human DTXSID0028030 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0028030 TK.Half.Life NA 0.8752 hours 1compartment NA NA Rat Human -DTXSID0028030 Css NA 0.0003748 mg/L 3compartmentss NA 50% Rat Human -DTXSID0028030 Css NA 0.002144 mg/L 3compartmentss NA 95% Rat Human -DTXSID0028030 Css NA 0.0002764 mg/L PBTK NA 50% Rat Human -DTXSID0028030 Css NA 0.001508 mg/L PBTK NA 95% Rat Human +DTXSID0028030 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human +DTXSID0028030 Css NA 0.01525 mg/L 3compartmentss NA 50% Rat Human +DTXSID0028030 Css NA 0.1076 mg/L 3compartmentss NA 95% Rat Human +DTXSID0028030 Css NA 0.0119 mg/L PBTK NA 50% Rat Human +DTXSID0028030 Css NA 0.07676 mg/L PBTK NA 95% Rat Human DTXSID0028038 Clint 486 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0028038 Fup 0.719 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0028038 Vd NA 2.147 L/kg 1compartment NA NA Human Human +DTXSID0028038 Vd NA 2.878 L/kg 1compartment NA NA Human Human DTXSID0028038 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0028038 TK.Half.Life NA 1.292 hours 1compartment NA NA Human Human -DTXSID0028038 Css NA 0.001708 mg/L 3compartmentss NA 50% Human Human -DTXSID0028038 Css NA 0.01517 mg/L 3compartmentss NA 95% Human Human -DTXSID0028038 Css NA 0.001516 mg/L PBTK NA 50% Human Human -DTXSID0028038 Css NA 0.012 mg/L PBTK NA 95% Human Human +DTXSID0028038 TK.Half.Life NA 2.07 hours 1compartment NA NA Human Human +DTXSID0028038 Css NA 0.003021 mg/L 3compartmentss NA 50% Human Human +DTXSID0028038 Css NA 0.03172 mg/L 3compartmentss NA 95% Human Human +DTXSID0028038 Css NA 0.00242 mg/L PBTK NA 50% Human Human +DTXSID0028038 Css NA 0.02365 mg/L PBTK NA 95% Human Human DTXSID0028038 Clint 486 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0028038 Fup 0.719 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0028038 Vd NA 1.762 L/kg 1compartment NA NA Rat Human +DTXSID0028038 Vd NA 2.233 L/kg 1compartment NA NA Rat Human DTXSID0028038 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0028038 TK.Half.Life NA 0.4516 hours 1compartment NA NA Rat Human -DTXSID0028038 Css NA 0.0009372 mg/L 3compartmentss NA 50% Rat Human -DTXSID0028038 Css NA 0.006457 mg/L 3compartmentss NA 95% Rat Human -DTXSID0028038 Css NA 0.0008203 mg/L PBTK NA 50% Rat Human -DTXSID0028038 Css NA 0.004888 mg/L PBTK NA 95% Rat Human -DTXSID0028323 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0028323 Fup NA 0.012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0028323 Vd NA 41.96 L/kg 1compartment NA NA Human Human -DTXSID0028323 Days.Css NA 13780 Days PBTK NA NA Human Human -DTXSID0028323 TK.Half.Life NA 2003000 hours 1compartment NA NA Human Human -DTXSID0028323 Css NA 810.2 mg/L 3compartmentss NA 50% Human Human -DTXSID0028323 Css NA 2026 mg/L 3compartmentss NA 95% Human Human -DTXSID0028323 Css NA 3681 mg/L PBTK NA 50% Human Human -DTXSID0028323 Css NA 7815 mg/L PBTK NA 95% Human Human -DTXSID0028323 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0028323 Fup NA 0.012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0028323 Vd NA 35.12 L/kg 1compartment NA NA Rat Human -DTXSID0028323 Days.Css NA 11150 Days PBTK NA NA Rat Human -DTXSID0028323 TK.Half.Life NA 141200 hours 1compartment NA NA Rat Human -DTXSID0028323 Css NA 200.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID0028323 Css NA 347.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID0028323 Css NA 988.3 mg/L PBTK NA 50% Rat Human -DTXSID0028323 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID0028618 Clint NA 29.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0028618 Fup NA 0.232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0028618 Vd NA 1.421 L/kg 1compartment NA NA Human Human -DTXSID0028618 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0028618 TK.Half.Life NA 1.967 hours 1compartment NA NA Human Human -DTXSID0028618 Css NA 0.0792 mg/L 3compartmentss NA 50% Human Human -DTXSID0028618 Css NA 0.5223 mg/L 3compartmentss NA 95% Human Human -DTXSID0028618 Css NA 0.05775 mg/L PBTK NA 50% Human Human -DTXSID0028618 Css NA 0.354 mg/L PBTK NA 95% Human Human -DTXSID0028618 Clint NA 29.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0028618 Fup NA 0.232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0028618 Vd NA 1.139 L/kg 1compartment NA NA Rat Human -DTXSID0028618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0028618 TK.Half.Life NA 0.7779 hours 1compartment NA NA Rat Human -DTXSID0028618 Css NA 0.04338 mg/L 3compartmentss NA 50% Rat Human -DTXSID0028618 Css NA 0.2331 mg/L 3compartmentss NA 95% Rat Human -DTXSID0028618 Css NA 0.03028 mg/L PBTK NA 50% Rat Human -DTXSID0028618 Css NA 0.1526 mg/L PBTK NA 95% Rat Human -DTXSID0028666 Clint NA 224 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0028666 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0028666 Vd NA 2524 L/kg 1compartment NA NA Human Human -DTXSID0028666 Days.Css NA 1981 Days PBTK NA NA Human Human -DTXSID0028666 TK.Half.Life NA 7366 hours 1compartment NA NA Human Human -DTXSID0028666 Css NA 0.0005598 mg/L 3compartmentss NA 50% Human Human -DTXSID0028666 Css NA 0.003494 mg/L 3compartmentss NA 95% Human Human -DTXSID0028666 Css NA 0.2424 mg/L PBTK NA 50% Human Human -DTXSID0028666 Css NA 1.351 mg/L PBTK NA 95% Human Human -DTXSID0028666 Clint NA 224 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0028666 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0028666 Vd NA 2344 L/kg 1compartment NA NA Rat Human -DTXSID0028666 Days.Css NA 1327 Days PBTK NA NA Rat Human -DTXSID0028666 TK.Half.Life NA 1265 hours 1compartment NA NA Rat Human -DTXSID0028666 Css NA 0.0002858 mg/L 3compartmentss NA 50% Rat Human -DTXSID0028666 Css NA 0.001259 mg/L 3compartmentss NA 95% Rat Human -DTXSID0028666 Css NA 0.1318 mg/L PBTK NA 50% Rat Human -DTXSID0028666 Css NA 0.5798 mg/L PBTK NA 95% Rat Human -DTXSID0029133 Clint NA 11.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029133 Fup NA 0.5127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029133 Vd NA 1.006 L/kg 1compartment NA NA Human Human +DTXSID0028038 TK.Half.Life NA 0.6658 hours 1compartment NA NA Rat Human +DTXSID0028038 Css NA 0.0004258 mg/L 3compartmentss NA 50% Rat Human +DTXSID0028038 Css NA 0.003378 mg/L 3compartmentss NA 95% Rat Human +DTXSID0028038 Css NA 0.000351 mg/L PBTK NA 50% Rat Human +DTXSID0028038 Css NA 0.002614 mg/L PBTK NA 95% Rat Human +DTXSID0029133 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0029133 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0029133 Vd NA 0.8249 L/kg 1compartment NA NA Human Human DTXSID0029133 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0029133 TK.Half.Life NA 1.277 hours 1compartment NA NA Human Human -DTXSID0029133 Css NA 0.07722 mg/L 3compartmentss NA 50% Human Human -DTXSID0029133 Css NA 0.6303 mg/L 3compartmentss NA 95% Human Human -DTXSID0029133 Css NA 0.06236 mg/L PBTK NA 50% Human Human -DTXSID0029133 Css NA 0.4387 mg/L PBTK NA 95% Human Human -DTXSID0029133 Clint NA 11.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029133 Fup NA 0.5127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029133 Vd NA 0.9058 L/kg 1compartment NA NA Rat Human +DTXSID0029133 TK.Half.Life NA 0.9763 hours 1compartment NA NA Human Human +DTXSID0029133 Css NA 0.05508 mg/L 3compartmentss NA 50% Human Human +DTXSID0029133 Css NA 0.4161 mg/L 3compartmentss NA 95% Human Human +DTXSID0029133 Css NA 0.04077 mg/L PBTK NA 50% Human Human +DTXSID0029133 Css NA 0.2866 mg/L PBTK NA 95% Human Human +DTXSID0029133 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0029133 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0029133 Vd NA 0.74 L/kg 1compartment NA NA Rat Human DTXSID0029133 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0029133 TK.Half.Life NA 0.5991 hours 1compartment NA NA Rat Human -DTXSID0029133 Css NA 0.04022 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029133 Css NA 0.2668 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029133 Css NA 0.03109 mg/L PBTK NA 50% Rat Human -DTXSID0029133 Css NA 0.1712 mg/L PBTK NA 95% Rat Human +DTXSID0029133 TK.Half.Life NA 0.4507 hours 1compartment NA NA Rat Human +DTXSID0029133 Css NA 0.0069 mg/L 3compartmentss NA 50% Rat Human +DTXSID0029133 Css NA 0.03933 mg/L 3compartmentss NA 95% Rat Human +DTXSID0029133 Css NA 0.005138 mg/L PBTK NA 50% Rat Human +DTXSID0029133 Css NA 0.02669 mg/L PBTK NA 95% Rat Human DTXSID0029189 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0029189 Fup NA 0.7883 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029189 Vd NA 0.957 L/kg 1compartment NA NA Human Human +DTXSID0029189 Vd NA 0.8874 L/kg 1compartment NA NA Human Human DTXSID0029189 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0029189 TK.Half.Life NA 7.854 hours 1compartment NA NA Human Human -DTXSID0029189 Css NA 0.9772 mg/L 3compartmentss NA 50% Human Human -DTXSID0029189 Css NA 5.97 mg/L 3compartmentss NA 95% Human Human -DTXSID0029189 Css NA 0.8236 mg/L PBTK NA 50% Human Human -DTXSID0029189 Css NA 3.823 mg/L PBTK NA 95% Human Human +DTXSID0029189 TK.Half.Life NA 7.282 hours 1compartment NA NA Human Human +DTXSID0029189 Css NA 0.8379 mg/L 3compartmentss NA 50% Human Human +DTXSID0029189 Css NA 5.291 mg/L 3compartmentss NA 95% Human Human +DTXSID0029189 Css NA 0.7018 mg/L PBTK NA 50% Human Human +DTXSID0029189 Css NA 3.39 mg/L PBTK NA 95% Human Human DTXSID0029189 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0029189 Fup NA 0.7883 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029189 Vd NA 0.9636 L/kg 1compartment NA NA Rat Human +DTXSID0029189 Vd NA 0.8993 L/kg 1compartment NA NA Rat Human DTXSID0029189 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0029189 TK.Half.Life NA 2.695 hours 1compartment NA NA Rat Human -DTXSID0029189 Css NA 0.2474 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029189 Css NA 1.556 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029189 Css NA 0.2032 mg/L PBTK NA 50% Rat Human -DTXSID0029189 Css NA 0.9353 mg/L PBTK NA 95% Rat Human -DTXSID0029210 Clint NA 468.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029210 Fup NA 0.0496 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029210 Vd NA 3.108 L/kg 1compartment NA NA Human Human -DTXSID0029210 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0029210 TK.Half.Life NA 5.728 hours 1compartment NA NA Human Human -DTXSID0029210 Css NA 0.1274 mg/L 3compartmentss NA 50% Human Human -DTXSID0029210 Css NA 0.816 mg/L 3compartmentss NA 95% Human Human -DTXSID0029210 Css NA 0.08856 mg/L PBTK NA 50% Human Human -DTXSID0029210 Css NA 0.5456 mg/L PBTK NA 95% Human Human -DTXSID0029210 Clint NA 468.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029210 Fup NA 0.0496 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029210 Vd NA 2.33 L/kg 1compartment NA NA Rat Human -DTXSID0029210 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0029210 TK.Half.Life NA 1.255 hours 1compartment NA NA Rat Human -DTXSID0029210 Css NA 0.07242 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029210 Css NA 0.3776 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029210 Css NA 0.04802 mg/L PBTK NA 50% Rat Human -DTXSID0029210 Css NA 0.2403 mg/L PBTK NA 95% Rat Human -DTXSID0029214 Clint NA 10.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029214 Fup NA 0.1078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029214 Vd NA 2.99 L/kg 1compartment NA NA Human Human -DTXSID0029214 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID0029214 TK.Half.Life NA 54.15 hours 1compartment NA NA Human Human -DTXSID0029214 Css NA 2.207 mg/L 3compartmentss NA 50% Human Human -DTXSID0029214 Css NA 13.37 mg/L 3compartmentss NA 95% Human Human -DTXSID0029214 Css NA 1.543 mg/L PBTK NA 50% Human Human -DTXSID0029214 Css NA 8.966 mg/L PBTK NA 95% Human Human -DTXSID0029214 Clint NA 10.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029214 Fup NA 0.1078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029214 Vd NA 2.247 L/kg 1compartment NA NA Rat Human -DTXSID0029214 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID0029214 TK.Half.Life NA 8.76 hours 1compartment NA NA Rat Human -DTXSID0029214 Css NA 1.21 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029214 Css NA 5.666 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029214 Css NA 0.8089 mg/L PBTK NA 50% Rat Human -DTXSID0029214 Css NA 3.655 mg/L PBTK NA 95% Rat Human -DTXSID0029260 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029260 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029260 Vd NA 0.9281 L/kg 1compartment NA NA Human Human +DTXSID0029189 TK.Half.Life NA 2.516 hours 1compartment NA NA Rat Human +DTXSID0029189 Css NA 0.01573 mg/L 3compartmentss NA 50% Rat Human +DTXSID0029189 Css NA 0.1248 mg/L 3compartmentss NA 95% Rat Human +DTXSID0029189 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID0029189 Css NA 0.08172 mg/L PBTK NA 95% Rat Human +DTXSID0029260 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0029260 Fup 0.886 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0029260 Vd NA 0.71 L/kg 1compartment NA NA Human Human DTXSID0029260 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0029260 TK.Half.Life NA 6.038 hours 1compartment NA NA Human Human -DTXSID0029260 Css NA 0.7958 mg/L 3compartmentss NA 50% Human Human -DTXSID0029260 Css NA 5.889 mg/L 3compartmentss NA 95% Human Human -DTXSID0029260 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID0029260 Css NA 3.763 mg/L PBTK NA 95% Human Human -DTXSID0029260 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029260 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029260 Vd NA 0.9442 L/kg 1compartment NA NA Rat Human +DTXSID0029260 TK.Half.Life NA 5.188 hours 1compartment NA NA Human Human +DTXSID0029260 Css NA 0.9162 mg/L 3compartmentss NA 50% Human Human +DTXSID0029260 Css NA 5.112 mg/L 3compartmentss NA 95% Human Human +DTXSID0029260 Css NA 0.7546 mg/L PBTK NA 50% Human Human +DTXSID0029260 Css NA 3.39 mg/L PBTK NA 95% Human Human +DTXSID0029260 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0029260 Fup 0.886 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0029260 Vd NA 0.747 L/kg 1compartment NA NA Rat Human DTXSID0029260 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0029260 TK.Half.Life NA 2.085 hours 1compartment NA NA Rat Human -DTXSID0029260 Css NA 0.2003 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029260 Css NA 1.297 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029260 Css NA 0.1725 mg/L PBTK NA 50% Rat Human -DTXSID0029260 Css NA 0.7914 mg/L PBTK NA 95% Rat Human -DTXSID0029262 Clint NA 24.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029262 Fup NA 0.0166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029262 Vd NA 3.018 L/kg 1compartment NA NA Human Human -DTXSID0029262 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID0029262 TK.Half.Life NA 60.8 hours 1compartment NA NA Human Human -DTXSID0029262 Css NA 2.55 mg/L 3compartmentss NA 50% Human Human -DTXSID0029262 Css NA 16.55 mg/L 3compartmentss NA 95% Human Human -DTXSID0029262 Css NA 1.748 mg/L PBTK NA 50% Human Human -DTXSID0029262 Css NA 10.82 mg/L PBTK NA 95% Human Human -DTXSID0029262 Clint NA 24.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029262 Fup NA 0.0166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029262 Vd NA 2.259 L/kg 1compartment NA NA Rat Human -DTXSID0029262 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID0029262 TK.Half.Life NA 9.461 hours 1compartment NA NA Rat Human -DTXSID0029262 Css NA 1.426 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029262 Css NA 7.711 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029262 Css NA 0.9353 mg/L PBTK NA 50% Rat Human -DTXSID0029262 Css NA 4.892 mg/L PBTK NA 95% Rat Human -DTXSID0029474 Clint NA 0.5527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029474 Fup NA 0.1173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029474 Vd NA 2.994 L/kg 1compartment NA NA Human Human -DTXSID0029474 Days.Css NA 156 Days PBTK NA NA Human Human -DTXSID0029474 TK.Half.Life NA 642.4 hours 1compartment NA NA Human Human -DTXSID0029474 Css NA 26.2 mg/L 3compartmentss NA 50% Human Human -DTXSID0029474 Css NA 89.36 mg/L 3compartmentss NA 95% Human Human -DTXSID0029474 Css NA 18.41 mg/L PBTK NA 50% Human Human -DTXSID0029474 Css NA 58.33 mg/L PBTK NA 95% Human Human -DTXSID0029474 Clint NA 0.5527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029474 Fup NA 0.1173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029474 Vd NA 2.25 L/kg 1compartment NA NA Rat Human -DTXSID0029474 Days.Css NA 61 Days PBTK NA NA Rat Human -DTXSID0029474 TK.Half.Life NA 76.37 hours 1compartment NA NA Rat Human -DTXSID0029474 Css NA 10.97 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029474 Css NA 26.28 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029474 Css NA 7.352 mg/L PBTK NA 50% Rat Human -DTXSID0029474 Css NA 16.11 mg/L PBTK NA 95% Rat Human -DTXSID0029559 Clint NA 64.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029559 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029559 Vd NA 0.5762 L/kg 1compartment NA NA Human Human +DTXSID0029260 TK.Half.Life NA 1.859 hours 1compartment NA NA Rat Human +DTXSID0029260 Css NA 0.05444 mg/L 3compartmentss NA 50% Rat Human +DTXSID0029260 Css NA 0.2944 mg/L 3compartmentss NA 95% Rat Human +DTXSID0029260 Css NA 0.04476 mg/L PBTK NA 50% Rat Human +DTXSID0029260 Css NA 0.1833 mg/L PBTK NA 95% Rat Human +DTXSID0029268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0029268 Fup 0.0583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0029268 Vd NA 0.4901 L/kg 1compartment NA NA Human Human +DTXSID0029268 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0029268 TK.Half.Life NA 1.862 hours 1compartment NA NA Human Human +DTXSID0029268 Css NA 0.4472 mg/L 3compartmentss NA 50% Human Human +DTXSID0029268 Css NA 3.652 mg/L 3compartmentss NA 95% Human Human +DTXSID0029268 Css NA 0.274 mg/L PBTK NA 50% Human Human +DTXSID0029268 Css NA 2.155 mg/L PBTK NA 95% Human Human +DTXSID0029268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0029268 Fup 0.0583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0029268 Vd NA 0.4091 L/kg 1compartment NA NA Rat Human +DTXSID0029268 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0029268 TK.Half.Life NA 0.9499 hours 1compartment NA NA Rat Human +DTXSID0029268 Css NA 0.02184 mg/L 3compartmentss NA 50% Rat Human +DTXSID0029268 Css NA 0.1999 mg/L 3compartmentss NA 95% Rat Human +DTXSID0029268 Css NA 0.01276 mg/L PBTK NA 50% Rat Human +DTXSID0029268 Css NA 0.1146 mg/L PBTK NA 95% Rat Human +DTXSID0029559 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0029559 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0029559 Vd NA 0.5128 L/kg 1compartment NA NA Human Human DTXSID0029559 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0029559 TK.Half.Life NA 0.3595 hours 1compartment NA NA Human Human -DTXSID0029559 Css NA 0.004896 mg/L 3compartmentss NA 50% Human Human -DTXSID0029559 Css NA 0.07002 mg/L 3compartmentss NA 95% Human Human -DTXSID0029559 Css NA 0.003827 mg/L PBTK NA 50% Human Human -DTXSID0029559 Css NA 0.04906 mg/L PBTK NA 95% Human Human -DTXSID0029559 Clint NA 64.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029559 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029559 Vd NA 0.6144 L/kg 1compartment NA NA Rat Human +DTXSID0029559 TK.Half.Life NA 7.422 hours 1compartment NA NA Human Human +DTXSID0029559 Css NA 0.8601 mg/L 3compartmentss NA 50% Human Human +DTXSID0029559 Css NA 4.22 mg/L 3compartmentss NA 95% Human Human +DTXSID0029559 Css NA 0.6496 mg/L PBTK NA 50% Human Human +DTXSID0029559 Css NA 2.688 mg/L PBTK NA 95% Human Human +DTXSID0029559 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0029559 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0029559 Vd NA 0.5195 L/kg 1compartment NA NA Rat Human DTXSID0029559 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0029559 TK.Half.Life NA 0.168 hours 1compartment NA NA Rat Human -DTXSID0029559 Css NA 0.002541 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029559 Css NA 0.03032 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029559 Css NA 0.001939 mg/L PBTK NA 50% Rat Human -DTXSID0029559 Css NA 0.02083 mg/L PBTK NA 95% Rat Human -DTXSID0029688 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029688 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029688 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID0029688 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0029688 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID0029688 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID0029688 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID0029688 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID0029688 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID0029688 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029688 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029688 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human -DTXSID0029688 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0029688 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID0029688 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029688 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029688 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID0029688 Css NA 1.296 mg/L PBTK NA 95% Rat Human +DTXSID0029559 TK.Half.Life NA 2.562 hours 1compartment NA NA Rat Human +DTXSID0029559 Css NA 0.00468 mg/L 3compartmentss NA 50% Rat Human +DTXSID0029559 Css NA 0.02321 mg/L 3compartmentss NA 95% Rat Human +DTXSID0029559 Css NA 0.00338 mg/L PBTK NA 50% Rat Human +DTXSID0029559 Css NA 0.01428 mg/L PBTK NA 95% Rat Human DTXSID0029761 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0029761 Fup NA 0.389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029761 Vd NA 0.3633 L/kg 1compartment NA NA Human Human +DTXSID0029761 Vd NA 0.35 L/kg 1compartment NA NA Human Human DTXSID0029761 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0029761 TK.Half.Life NA 6.043 hours 1compartment NA NA Human Human -DTXSID0029761 Css NA 2.003 mg/L 3compartmentss NA 50% Human Human -DTXSID0029761 Css NA 8.329 mg/L 3compartmentss NA 95% Human Human -DTXSID0029761 Css NA 1.376 mg/L PBTK NA 50% Human Human -DTXSID0029761 Css NA 5.102 mg/L PBTK NA 95% Human Human +DTXSID0029761 TK.Half.Life NA 5.82 hours 1compartment NA NA Human Human +DTXSID0029761 Css NA 1.96 mg/L 3compartmentss NA 50% Human Human +DTXSID0029761 Css NA 8.217 mg/L 3compartmentss NA 95% Human Human +DTXSID0029761 Css NA 1.338 mg/L PBTK NA 50% Human Human +DTXSID0029761 Css NA 5.002 mg/L PBTK NA 95% Human Human DTXSID0029761 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0029761 Fup NA 0.389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029761 Vd NA 0.3698 L/kg 1compartment NA NA Rat Human +DTXSID0029761 Vd NA 0.358 L/kg 1compartment NA NA Rat Human DTXSID0029761 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0029761 TK.Half.Life NA 2.096 hours 1compartment NA NA Rat Human -DTXSID0029761 Css NA 0.5546 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029761 Css NA 1.932 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029761 Css NA 0.3589 mg/L PBTK NA 50% Rat Human -DTXSID0029761 Css NA 1.11 mg/L PBTK NA 95% Rat Human -DTXSID0029848 Clint NA 8.069 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029848 Fup NA 0.1235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0029848 Vd NA 2.954 L/kg 1compartment NA NA Human Human -DTXSID0029848 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID0029848 TK.Half.Life NA 54.11 hours 1compartment NA NA Human Human -DTXSID0029848 Css NA 2.234 mg/L 3compartmentss NA 50% Human Human -DTXSID0029848 Css NA 13.01 mg/L 3compartmentss NA 95% Human Human -DTXSID0029848 Css NA 1.566 mg/L PBTK NA 50% Human Human -DTXSID0029848 Css NA 8.727 mg/L PBTK NA 95% Human Human -DTXSID0029848 Clint NA 8.069 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029848 Fup NA 0.1235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0029848 Vd NA 2.222 L/kg 1compartment NA NA Rat Human -DTXSID0029848 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID0029848 TK.Half.Life NA 9.038 hours 1compartment NA NA Rat Human -DTXSID0029848 Css NA 1.211 mg/L 3compartmentss NA 50% Rat Human -DTXSID0029848 Css NA 5.324 mg/L 3compartmentss NA 95% Rat Human -DTXSID0029848 Css NA 0.8104 mg/L PBTK NA 50% Rat Human -DTXSID0029848 Css NA 3.526 mg/L PBTK NA 95% Rat Human -DTXSID0030162 Clint NA 3.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0030162 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0030162 Vd NA 1.533 L/kg 1compartment NA NA Human Human +DTXSID0029761 TK.Half.Life NA 2.029 hours 1compartment NA NA Rat Human +DTXSID0029761 Css NA 0.1259 mg/L 3compartmentss NA 50% Rat Human +DTXSID0029761 Css NA 0.4364 mg/L 3compartmentss NA 95% Rat Human +DTXSID0029761 Css NA 0.0838 mg/L PBTK NA 50% Rat Human +DTXSID0029761 Css NA 0.259 mg/L PBTK NA 95% Rat Human +DTXSID0030162 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0030162 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0030162 Vd NA 0.8086 L/kg 1compartment NA NA Human Human DTXSID0030162 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0030162 TK.Half.Life NA 2.083 hours 1compartment NA NA Human Human -DTXSID0030162 Css NA 0.107 mg/L 3compartmentss NA 50% Human Human -DTXSID0030162 Css NA 0.9666 mg/L 3compartmentss NA 95% Human Human -DTXSID0030162 Css NA 0.1014 mg/L PBTK NA 50% Human Human -DTXSID0030162 Css NA 0.7245 mg/L PBTK NA 95% Human Human -DTXSID0030162 Clint NA 3.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0030162 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0030162 Vd NA 1.402 L/kg 1compartment NA NA Rat Human +DTXSID0030162 TK.Half.Life NA 0.9106 hours 1compartment NA NA Human Human +DTXSID0030162 Css NA 0.04067 mg/L 3compartmentss NA 50% Human Human +DTXSID0030162 Css NA 0.3332 mg/L 3compartmentss NA 95% Human Human +DTXSID0030162 Css NA 0.03091 mg/L PBTK NA 50% Human Human +DTXSID0030162 Css NA 0.2327 mg/L PBTK NA 95% Human Human +DTXSID0030162 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0030162 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0030162 Vd NA 0.7475 L/kg 1compartment NA NA Rat Human DTXSID0030162 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0030162 TK.Half.Life NA 0.9519 hours 1compartment NA NA Rat Human -DTXSID0030162 Css NA 0.04745 mg/L 3compartmentss NA 50% Rat Human -DTXSID0030162 Css NA 0.335 mg/L 3compartmentss NA 95% Rat Human -DTXSID0030162 Css NA 0.04526 mg/L PBTK NA 50% Rat Human -DTXSID0030162 Css NA 0.2305 mg/L PBTK NA 95% Rat Human -DTXSID0030588 Clint NA 24.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0030588 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0030588 Vd NA 2.098 L/kg 1compartment NA NA Human Human -DTXSID0030588 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0030588 TK.Half.Life NA 1.187 hours 1compartment NA NA Human Human -DTXSID0030588 Css NA 0.01704 mg/L 3compartmentss NA 50% Human Human -DTXSID0030588 Css NA 0.2277 mg/L 3compartmentss NA 95% Human Human -DTXSID0030588 Css NA 0.01769 mg/L PBTK NA 50% Human Human -DTXSID0030588 Css NA 0.1985 mg/L PBTK NA 95% Human Human -DTXSID0030588 Clint NA 24.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0030588 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0030588 Vd NA 2.124 L/kg 1compartment NA NA Rat Human +DTXSID0030162 TK.Half.Life NA 0.4324 hours 1compartment NA NA Rat Human +DTXSID0030162 Css NA 0.001422 mg/L 3compartmentss NA 50% Rat Human +DTXSID0030162 Css NA 0.01336 mg/L 3compartmentss NA 95% Rat Human +DTXSID0030162 Css NA 0.00106 mg/L PBTK NA 50% Rat Human +DTXSID0030162 Css NA 0.008964 mg/L PBTK NA 95% Rat Human +DTXSID0030588 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0030588 Fup 0.735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0030588 Vd NA 1.699 L/kg 1compartment NA NA Human Human +DTXSID0030588 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0030588 TK.Half.Life NA 14.95 hours 1compartment NA NA Human Human +DTXSID0030588 Css NA 0.8532 mg/L 3compartmentss NA 50% Human Human +DTXSID0030588 Css NA 6.3 mg/L 3compartmentss NA 95% Human Human +DTXSID0030588 Css NA 0.8277 mg/L PBTK NA 50% Human Human +DTXSID0030588 Css NA 4.247 mg/L PBTK NA 95% Human Human +DTXSID0030588 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0030588 Fup 0.735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0030588 Vd NA 1.716 L/kg 1compartment NA NA Rat Human DTXSID0030588 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0030588 TK.Half.Life NA 0.5835 hours 1compartment NA NA Rat Human -DTXSID0030588 Css NA 0.008465 mg/L 3compartmentss NA 50% Rat Human -DTXSID0030588 Css NA 0.09269 mg/L 3compartmentss NA 95% Rat Human -DTXSID0030588 Css NA 0.00887 mg/L PBTK NA 50% Rat Human -DTXSID0030588 Css NA 0.07509 mg/L PBTK NA 95% Rat Human -DTXSID0032029 Clint NA 37.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032029 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032029 Vd NA 0.8566 L/kg 1compartment NA NA Human Human +DTXSID0030588 TK.Half.Life NA 5.146 hours 1compartment NA NA Rat Human +DTXSID0030588 Css NA 0.04977 mg/L 3compartmentss NA 50% Rat Human +DTXSID0030588 Css NA 0.3643 mg/L 3compartmentss NA 95% Rat Human +DTXSID0030588 Css NA 0.0496 mg/L PBTK NA 50% Rat Human +DTXSID0030588 Css NA 0.2372 mg/L PBTK NA 95% Rat Human +DTXSID0032029 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032029 Fup 0.484 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032029 Vd NA 0.9869 L/kg 1compartment NA NA Human Human DTXSID0032029 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0032029 TK.Half.Life NA 0.8857 hours 1compartment NA NA Human Human -DTXSID0032029 Css NA 0.0387 mg/L 3compartmentss NA 50% Human Human -DTXSID0032029 Css NA 0.2997 mg/L 3compartmentss NA 95% Human Human -DTXSID0032029 Css NA 0.02872 mg/L PBTK NA 50% Human Human -DTXSID0032029 Css NA 0.2061 mg/L PBTK NA 95% Human Human -DTXSID0032029 Clint NA 37.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032029 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032029 Vd NA 0.8182 L/kg 1compartment NA NA Rat Human +DTXSID0032029 TK.Half.Life NA 1.712 hours 1compartment NA NA Human Human +DTXSID0032029 Css NA 0.1286 mg/L 3compartmentss NA 50% Human Human +DTXSID0032029 Css NA 0.9659 mg/L 3compartmentss NA 95% Human Human +DTXSID0032029 Css NA 0.1037 mg/L PBTK NA 50% Human Human +DTXSID0032029 Css NA 0.6518 mg/L PBTK NA 95% Human Human +DTXSID0032029 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032029 Fup 0.484 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032029 Vd NA 0.9638 L/kg 1compartment NA NA Rat Human DTXSID0032029 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0032029 TK.Half.Life NA 0.4247 hours 1compartment NA NA Rat Human -DTXSID0032029 Css NA 0.02098 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032029 Css NA 0.1287 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032029 Css NA 0.015 mg/L PBTK NA 50% Rat Human -DTXSID0032029 Css NA 0.08285 mg/L PBTK NA 95% Rat Human -DTXSID0032077 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032077 Fup NA 0.4935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032077 Vd NA 0.534 L/kg 1compartment NA NA Human Human -DTXSID0032077 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0032077 TK.Half.Life NA 7.001 hours 1compartment NA NA Human Human -DTXSID0032077 Css NA 1.474 mg/L 3compartmentss NA 50% Human Human -DTXSID0032077 Css NA 7.614 mg/L 3compartmentss NA 95% Human Human -DTXSID0032077 Css NA 1.114 mg/L PBTK NA 50% Human Human -DTXSID0032077 Css NA 4.762 mg/L PBTK NA 95% Human Human -DTXSID0032077 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032077 Fup NA 0.4935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032077 Vd NA 0.5562 L/kg 1compartment NA NA Rat Human -DTXSID0032077 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0032077 TK.Half.Life NA 2.485 hours 1compartment NA NA Rat Human -DTXSID0032077 Css NA 0.397 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032077 Css NA 1.821 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032077 Css NA 0.2864 mg/L PBTK NA 50% Rat Human -DTXSID0032077 Css NA 1.071 mg/L PBTK NA 95% Rat Human +DTXSID0032029 TK.Half.Life NA 0.9186 hours 1compartment NA NA Rat Human +DTXSID0032029 Css NA 0.01447 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032029 Css NA 0.09125 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032029 Css NA 0.01182 mg/L PBTK NA 50% Rat Human +DTXSID0032029 Css NA 0.05987 mg/L PBTK NA 95% Rat Human DTXSID0032314 Clint NA 0.2295 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0032314 Fup NA 0.7817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0032314 Vd NA 2.076 L/kg 1compartment NA NA Human Human DTXSID0032314 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID0032314 TK.Half.Life NA 12.73 hours 1compartment NA NA Human Human -DTXSID0032314 Css NA 0.576 mg/L 3compartmentss NA 50% Human Human -DTXSID0032314 Css NA 4.2 mg/L 3compartmentss NA 95% Human Human -DTXSID0032314 Css NA 0.5878 mg/L PBTK NA 50% Human Human -DTXSID0032314 Css NA 2.907 mg/L PBTK NA 95% Human Human +DTXSID0032314 Css NA 0.4884 mg/L 3compartmentss NA 50% Human Human +DTXSID0032314 Css NA 3.626 mg/L 3compartmentss NA 95% Human Human +DTXSID0032314 Css NA 0.4991 mg/L PBTK NA 50% Human Human +DTXSID0032314 Css NA 2.499 mg/L PBTK NA 95% Human Human DTXSID0032314 Clint NA 0.2295 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0032314 Fup NA 0.7817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0032314 Vd NA 2.087 L/kg 1compartment NA NA Rat Human DTXSID0032314 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0032314 TK.Half.Life NA 4.997 hours 1compartment NA NA Rat Human -DTXSID0032314 Css NA 0.1748 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032314 Css NA 1.266 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032314 Css NA 0.1757 mg/L PBTK NA 50% Rat Human -DTXSID0032314 Css NA 0.8142 mg/L PBTK NA 95% Rat Human -DTXSID0032316 Clint NA 14.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032316 Fup NA 0.1333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032316 Vd NA 2.432 L/kg 1compartment NA NA Human Human +DTXSID0032314 Css NA 0.01094 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032314 Css NA 0.102 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032314 Css NA 0.0108 mg/L PBTK NA 50% Rat Human +DTXSID0032314 Css NA 0.07235 mg/L PBTK NA 95% Rat Human +DTXSID0032316 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032316 Fup 0.0829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032316 Vd NA 2.139 L/kg 1compartment NA NA Human Human DTXSID0032316 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0032316 TK.Half.Life NA 11.46 hours 1compartment NA NA Human Human -DTXSID0032316 Css NA 0.5444 mg/L 3compartmentss NA 50% Human Human -DTXSID0032316 Css NA 3.382 mg/L 3compartmentss NA 95% Human Human -DTXSID0032316 Css NA 0.3804 mg/L PBTK NA 50% Human Human -DTXSID0032316 Css NA 2.202 mg/L PBTK NA 95% Human Human -DTXSID0032316 Clint NA 14.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032316 Fup NA 0.1333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032316 Vd NA 1.841 L/kg 1compartment NA NA Rat Human +DTXSID0032316 TK.Half.Life NA 8.615 hours 1compartment NA NA Human Human +DTXSID0032316 Css NA 0.4667 mg/L 3compartmentss NA 50% Human Human +DTXSID0032316 Css NA 3.217 mg/L 3compartmentss NA 95% Human Human +DTXSID0032316 Css NA 0.3139 mg/L PBTK NA 50% Human Human +DTXSID0032316 Css NA 2.076 mg/L PBTK NA 95% Human Human +DTXSID0032316 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032316 Fup 0.0829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032316 Vd NA 1.612 L/kg 1compartment NA NA Rat Human DTXSID0032316 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0032316 TK.Half.Life NA 3.111 hours 1compartment NA NA Rat Human -DTXSID0032316 Css NA 0.2941 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032316 Css NA 1.435 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032316 Css NA 0.1955 mg/L PBTK NA 50% Rat Human -DTXSID0032316 Css NA 0.903 mg/L PBTK NA 95% Rat Human +DTXSID0032316 TK.Half.Life NA 2.688 hours 1compartment NA NA Rat Human +DTXSID0032316 Css NA 0.06026 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032316 Css NA 0.3261 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032316 Css NA 0.04003 mg/L PBTK NA 50% Rat Human +DTXSID0032316 Css NA 0.2057 mg/L PBTK NA 95% Rat Human DTXSID0032493 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032493 Fup 0.1258 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032493 Vd NA 1.916 L/kg 1compartment NA NA Human Human DTXSID0032493 Days.Css NA 35 Days PBTK NA NA Human Human DTXSID0032493 TK.Half.Life NA 170.3 hours 1compartment NA NA Human Human -DTXSID0032493 Css NA 11.82 mg/L 3compartmentss NA 50% Human Human -DTXSID0032493 Css NA 44.36 mg/L 3compartmentss NA 95% Human Human -DTXSID0032493 Css NA 8.108 mg/L PBTK NA 50% Human Human -DTXSID0032493 Css NA 27.71 mg/L PBTK NA 95% Human Human +DTXSID0032493 Css NA 11.37 mg/L 3compartmentss NA 50% Human Human +DTXSID0032493 Css NA 43.03 mg/L 3compartmentss NA 95% Human Human +DTXSID0032493 Css NA 7.802 mg/L PBTK NA 50% Human Human +DTXSID0032493 Css NA 26.66 mg/L PBTK NA 95% Human Human DTXSID0032493 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0032493 Fup 0.1258 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0032493 Vd NA 1.461 L/kg 1compartment NA NA Rat Human DTXSID0032493 Days.Css NA 7 Days PBTK NA NA Rat Human DTXSID0032493 TK.Half.Life NA 30.05 hours 1compartment NA NA Rat Human -DTXSID0032493 Css NA 3.23 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032493 Css NA 10.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032493 Css NA 2.104 mg/L PBTK NA 50% Rat Human -DTXSID0032493 Css NA 6.027 mg/L PBTK NA 95% Rat Human +DTXSID0032493 Css NA 0.7256 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032493 Css NA 2.307 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032493 Css NA 0.4897 mg/L PBTK NA 50% Rat Human +DTXSID0032493 Css NA 1.385 mg/L PBTK NA 95% Rat Human DTXSID0032497 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032497 Fup 0.02237 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID0032497 Vd NA 0.2334 L/kg 1compartment NA NA Human Human -DTXSID0032497 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID0032497 TK.Half.Life NA 67.49 hours 1compartment NA NA Human Human -DTXSID0032497 Css NA 49.9 mg/L 3compartmentss NA 50% Human Human -DTXSID0032497 Css NA 306.7 mg/L 3compartmentss NA 95% Human Human -DTXSID0032497 Css NA 29.48 mg/L PBTK NA 50% Human Human -DTXSID0032497 Css NA 176.7 mg/L PBTK NA 95% Human Human +DTXSID0032497 Vd NA 125.6 L/kg 1compartment NA NA Human Human +DTXSID0032497 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID0032497 TK.Half.Life NA 42270 hours 1compartment NA NA Human Human +DTXSID0032497 Css NA 2.434 mg/L 3compartmentss NA 50% Human Human +DTXSID0032497 Css NA 52.03 mg/L 3compartmentss NA 95% Human Human +DTXSID0032497 Css NA 32.56 mg/L PBTK NA 50% Human Human +DTXSID0032497 Css NA 180.6 mg/L PBTK NA 95% Human Human DTXSID0032497 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0032497 Fup 0.02237 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID0032497 Vd NA 0.2287 L/kg 1compartment NA NA Rat Human -DTXSID0032497 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0032497 TK.Half.Life NA 22.54 hours 1compartment NA NA Rat Human -DTXSID0032497 Css NA 14.03 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032497 Css NA 75.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032497 Css NA 7.778 mg/L PBTK NA 50% Rat Human -DTXSID0032497 Css NA 40.98 mg/L PBTK NA 95% Rat Human +DTXSID0032497 Vd NA 109.4 L/kg 1compartment NA NA Rat Human +DTXSID0032497 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID0032497 TK.Half.Life NA 11200 hours 1compartment NA NA Rat Human +DTXSID0032497 Css NA 0.1365 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032497 Css NA 2.666 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032497 Css NA 2.051 mg/L PBTK NA 50% Rat Human +DTXSID0032497 Css NA 9.696 mg/L PBTK NA 95% Rat Human DTXSID0032520 Clint 32.39 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032520 Fup 0.04763 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032520 Vd NA 0.8404 L/kg 1compartment NA NA Human Human DTXSID0032520 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0032520 TK.Half.Life NA 2.778 hours 1compartment NA NA Human Human -DTXSID0032520 Css NA 0.4338 mg/L 3compartmentss NA 50% Human Human -DTXSID0032520 Css NA 3.716 mg/L 3compartmentss NA 95% Human Human -DTXSID0032520 Css NA 0.268 mg/L PBTK NA 50% Human Human +DTXSID0032520 Css NA 0.4215 mg/L 3compartmentss NA 50% Human Human +DTXSID0032520 Css NA 3.66 mg/L 3compartmentss NA 95% Human Human +DTXSID0032520 Css NA 0.2612 mg/L PBTK NA 50% Human Human DTXSID0032520 Css NA 2.204 mg/L PBTK NA 95% Human Human DTXSID0032520 Clint 32.39 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0032520 Fup 0.04763 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0032520 Vd NA 0.6481 L/kg 1compartment NA NA Rat Human DTXSID0032520 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0032520 TK.Half.Life NA 1.244 hours 1compartment NA NA Rat Human -DTXSID0032520 Css NA 0.2444 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032520 Css NA 1.649 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032520 Css NA 0.1416 mg/L PBTK NA 50% Rat Human -DTXSID0032520 Css NA 0.9325 mg/L PBTK NA 95% Rat Human -DTXSID0032572 Clint NA 52.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032572 Fup NA 0.0543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032572 Vd NA 2.994 L/kg 1compartment NA NA Human Human -DTXSID0032572 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0032572 TK.Half.Life NA 17.94 hours 1compartment NA NA Human Human -DTXSID0032572 Css NA 0.6759 mg/L 3compartmentss NA 50% Human Human -DTXSID0032572 Css NA 4.341 mg/L 3compartmentss NA 95% Human Human -DTXSID0032572 Css NA 0.4692 mg/L PBTK NA 50% Human Human -DTXSID0032572 Css NA 2.918 mg/L PBTK NA 95% Human Human -DTXSID0032572 Clint NA 52.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032572 Fup NA 0.0543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032572 Vd NA 2.245 L/kg 1compartment NA NA Rat Human -DTXSID0032572 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0032572 TK.Half.Life NA 3.2 hours 1compartment NA NA Rat Human -DTXSID0032572 Css NA 0.3777 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032572 Css NA 2.027 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032572 Css NA 0.2492 mg/L PBTK NA 50% Rat Human -DTXSID0032572 Css NA 1.315 mg/L PBTK NA 95% Rat Human +DTXSID0032520 Css NA 0.05586 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032520 Css NA 0.377 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032520 Css NA 0.03348 mg/L PBTK NA 50% Rat Human +DTXSID0032520 Css NA 0.221 mg/L PBTK NA 95% Rat Human +DTXSID0032572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032572 Fup 0.044 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032572 Vd NA 2.959 L/kg 1compartment NA NA Human Human +DTXSID0032572 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID0032572 TK.Half.Life NA 40.04 hours 1compartment NA NA Human Human +DTXSID0032572 Css NA 1.624 mg/L 3compartmentss NA 50% Human Human +DTXSID0032572 Css NA 11.04 mg/L 3compartmentss NA 95% Human Human +DTXSID0032572 Css NA 1.111 mg/L PBTK NA 50% Human Human +DTXSID0032572 Css NA 7.377 mg/L PBTK NA 95% Human Human +DTXSID0032572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032572 Fup 0.044 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032572 Vd NA 2.217 L/kg 1compartment NA NA Rat Human +DTXSID0032572 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0032572 TK.Half.Life NA 6.829 hours 1compartment NA NA Rat Human +DTXSID0032572 Css NA 0.2133 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032572 Css NA 1.123 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032572 Css NA 0.1452 mg/L PBTK NA 50% Rat Human +DTXSID0032572 Css NA 0.7536 mg/L PBTK NA 95% Rat Human DTXSID0032578 Clint 839 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0032578 Fup NA 0.2439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032578 Vd NA 0.6475 L/kg 1compartment NA NA Human Human +DTXSID0032578 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032578 Vd NA 0.6961 L/kg 1compartment NA NA Human Human DTXSID0032578 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0032578 TK.Half.Life NA 0.532 hours 1compartment NA NA Human Human -DTXSID0032578 Css NA 0.00247 mg/L 3compartmentss NA 50% Human Human -DTXSID0032578 Css NA 0.01884 mg/L 3compartmentss NA 95% Human Human -DTXSID0032578 Css NA 0.001697 mg/L PBTK NA 50% Human Human -DTXSID0032578 Css NA 0.0125 mg/L PBTK NA 95% Human Human +DTXSID0032578 TK.Half.Life NA 0.5559 hours 1compartment NA NA Human Human +DTXSID0032578 Css NA 0.000962 mg/L 3compartmentss NA 50% Human Human +DTXSID0032578 Css NA 0.01356 mg/L 3compartmentss NA 95% Human Human +DTXSID0032578 Css NA 0.0006751 mg/L PBTK NA 50% Human Human +DTXSID0032578 Css NA 0.008853 mg/L PBTK NA 95% Human Human DTXSID0032578 Clint 839 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0032578 Fup NA 0.2439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032578 Vd NA 0.5689 L/kg 1compartment NA NA Rat Human +DTXSID0032578 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032578 Vd NA 0.6121 L/kg 1compartment NA NA Rat Human DTXSID0032578 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0032578 TK.Half.Life NA 0.2056 hours 1compartment NA NA Rat Human -DTXSID0032578 Css NA 0.001372 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032578 Css NA 0.008628 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032578 Css NA 0.0008936 mg/L PBTK NA 50% Rat Human -DTXSID0032578 Css NA 0.005232 mg/L PBTK NA 95% Rat Human +DTXSID0032578 TK.Half.Life NA 0.2144 hours 1compartment NA NA Rat Human +DTXSID0032578 Css NA 0.000142 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032578 Css NA 0.001489 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032578 Css NA 0.0001003 mg/L PBTK NA 50% Rat Human +DTXSID0032578 Css NA 0.0009941 mg/L PBTK NA 95% Rat Human DTXSID0032601 Clint 1.538 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032601 Fup 0.1086 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032601 Vd NA 1.806 L/kg 1compartment NA NA Human Human DTXSID0032601 Days.Css NA 6 Days PBTK NA NA Human Human DTXSID0032601 TK.Half.Life NA 42.76 hours 1compartment NA NA Human Human -DTXSID0032601 Css NA 3.106 mg/L 3compartmentss NA 50% Human Human -DTXSID0032601 Css NA 15.59 mg/L 3compartmentss NA 95% Human Human -DTXSID0032601 Css NA 2.272 mg/L PBTK NA 50% Human Human -DTXSID0032601 Css NA 10.02 mg/L PBTK NA 95% Human Human +DTXSID0032601 Css NA 2.652 mg/L 3compartmentss NA 50% Human Human +DTXSID0032601 Css NA 11.89 mg/L 3compartmentss NA 95% Human Human +DTXSID0032601 Css NA 2.214 mg/L PBTK NA 50% Human Human +DTXSID0032601 Css NA 9.93 mg/L PBTK NA 95% Human Human DTXSID0032601 Clint 2.312 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0032601 Fup 0.1195 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0032601 Vd NA 1.427 L/kg 1compartment NA NA Rat Rat DTXSID0032601 Days.Css NA 1 Days PBTK NA NA Rat Rat DTXSID0032601 TK.Half.Life NA 9.493 hours 1compartment NA NA Rat Rat -DTXSID0032601 Css NA 1.031 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0032601 Css NA 3.92 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0032601 Css NA 0.7046 mg/L PBTK NA 50% Rat Rat -DTXSID0032601 Css NA 2.367 mg/L PBTK NA 95% Rat Rat +DTXSID0032601 Css NA 0.1888 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0032601 Css NA 0.6542 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0032601 Css NA 0.1634 mg/L PBTK NA 50% Rat Rat +DTXSID0032601 Css NA 0.5661 mg/L PBTK NA 95% Rat Rat DTXSID0032605 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID0032605 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032605 Vd NA 2.808 L/kg 1compartment NA NA Human Human -DTXSID0032605 Days.Css NA 2215 Days PBTK NA NA Human Human -DTXSID0032605 TK.Half.Life NA 8083 hours 1compartment NA NA Human Human -DTXSID0032605 Css NA 367.3 mg/L 3compartmentss NA 50% Human Human -DTXSID0032605 Css NA 1156 mg/L 3compartmentss NA 95% Human Human -DTXSID0032605 Css NA 248.2 mg/L PBTK NA 50% Human Human -DTXSID0032605 Css NA 730.2 mg/L PBTK NA 95% Human Human +DTXSID0032605 Fup 0.00549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032605 Vd NA 2.426 L/kg 1compartment NA NA Human Human +DTXSID0032605 Days.Css NA 2395 Days PBTK NA NA Human Human +DTXSID0032605 TK.Half.Life NA 8735 hours 1compartment NA NA Human Human +DTXSID0032605 Css NA 491 mg/L 3compartmentss NA 50% Human Human +DTXSID0032605 Css NA 1832 mg/L 3compartmentss NA 95% Human Human +DTXSID0032605 Css NA 320.4 mg/L PBTK NA 50% Human Human +DTXSID0032605 Css NA 1122 mg/L PBTK NA 95% Human Human DTXSID0032605 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID0032605 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032605 Vd NA 2.098 L/kg 1compartment NA NA Rat Human -DTXSID0032605 Days.Css NA 558 Days PBTK NA NA Rat Human -DTXSID0032605 TK.Half.Life NA 738.6 hours 1compartment NA NA Rat Human -DTXSID0032605 Css NA 100.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032605 Css NA 264.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032605 Css NA 64.62 mg/L PBTK NA 50% Rat Human -DTXSID0032605 Css NA 154.2 mg/L PBTK NA 95% Rat Human +DTXSID0032605 Fup 0.00549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032605 Vd NA 1.804 L/kg 1compartment NA NA Rat Human +DTXSID0032605 Days.Css NA 600 Days PBTK NA NA Rat Human +DTXSID0032605 TK.Half.Life NA 1080 hours 1compartment NA NA Rat Human +DTXSID0032605 Css NA 31.06 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032605 Css NA 97.57 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032605 Css NA 19.88 mg/L PBTK NA 50% Rat Human +DTXSID0032605 Css NA 57.32 mg/L PBTK NA 95% Rat Human DTXSID0032651 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032651 Fup 0.02837 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032651 Vd NA 0.2946 L/kg 1compartment NA NA Human Human DTXSID0032651 Days.Css NA 14 Days PBTK NA NA Human Human DTXSID0032651 TK.Half.Life NA 67.69 hours 1compartment NA NA Human Human -DTXSID0032651 Css NA 32.74 mg/L 3compartmentss NA 50% Human Human -DTXSID0032651 Css NA 226.8 mg/L 3compartmentss NA 95% Human Human -DTXSID0032651 Css NA 23.27 mg/L PBTK NA 50% Human Human -DTXSID0032651 Css NA 137.3 mg/L PBTK NA 95% Human Human +DTXSID0032651 Css NA 31.14 mg/L 3compartmentss NA 50% Human Human +DTXSID0032651 Css NA 184.7 mg/L 3compartmentss NA 95% Human Human +DTXSID0032651 Css NA 22.7 mg/L PBTK NA 50% Human Human +DTXSID0032651 Css NA 134.6 mg/L PBTK NA 95% Human Human DTXSID0032651 Clint 2.142 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0032651 Fup 0.1645 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0032651 Vd NA 0.5565 L/kg 1compartment NA NA Rat Rat DTXSID0032651 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID0032651 TK.Half.Life NA 2.775 hours 1compartment NA NA Rat Rat -DTXSID0032651 Css NA 0.4927 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0032651 Css NA 2.031 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0032651 Css NA 0.3442 mg/L PBTK NA 50% Rat Rat -DTXSID0032651 Css NA 1.203 mg/L PBTK NA 95% Rat Rat +DTXSID0032651 Css NA 0.1073 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0032651 Css NA 0.3729 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0032651 Css NA 0.08094 mg/L PBTK NA 50% Rat Rat +DTXSID0032651 Css NA 0.2815 mg/L PBTK NA 95% Rat Rat DTXSID0032655 Clint 6.118 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032655 Fup 0.1373 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0032655 Vd NA 2.418 L/kg 1compartment NA NA Human Human DTXSID0032655 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID0032655 TK.Half.Life NA 22.24 hours 1compartment NA NA Human Human -DTXSID0032655 Css NA 1.223 mg/L 3compartmentss NA 50% Human Human -DTXSID0032655 Css NA 7.001 mg/L 3compartmentss NA 95% Human Human -DTXSID0032655 Css NA 0.8229 mg/L PBTK NA 50% Human Human -DTXSID0032655 Css NA 4.511 mg/L PBTK NA 95% Human Human +DTXSID0032655 Css NA 0.9234 mg/L 3compartmentss NA 50% Human Human +DTXSID0032655 Css NA 5.101 mg/L 3compartmentss NA 95% Human Human +DTXSID0032655 Css NA 0.7896 mg/L PBTK NA 50% Human Human +DTXSID0032655 Css NA 4.364 mg/L PBTK NA 95% Human Human DTXSID0032655 Clint 17.98 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID0032655 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID0032655 Css NA 2.572 mg/L 3compartmentss NA 50% Rat Rat -DTXSID0032655 Css NA 23.89 mg/L 3compartmentss NA 95% Rat Rat -DTXSID0032811 Clint NA 0.007434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032811 Fup NA 0.3643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032811 Vd NA 0.4904 L/kg 1compartment NA NA Human Human +DTXSID0032655 Css NA 0.522 mg/L 3compartmentss NA 50% Rat Rat +DTXSID0032655 Css NA 4.061 mg/L 3compartmentss NA 95% Rat Rat +DTXSID0032811 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032811 Fup 0.554 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032811 Vd NA 0.6186 L/kg 1compartment NA NA Human Human DTXSID0032811 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0032811 TK.Half.Life NA 8.609 hours 1compartment NA NA Human Human -DTXSID0032811 Css NA 1.953 mg/L 3compartmentss NA 50% Human Human -DTXSID0032811 Css NA 8.245 mg/L 3compartmentss NA 95% Human Human -DTXSID0032811 Css NA 1.445 mg/L PBTK NA 50% Human Human -DTXSID0032811 Css NA 5.211 mg/L PBTK NA 95% Human Human -DTXSID0032811 Clint NA 0.007434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032811 Fup NA 0.3643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032811 Vd NA 0.4882 L/kg 1compartment NA NA Rat Human +DTXSID0032811 TK.Half.Life NA 7.233 hours 1compartment NA NA Human Human +DTXSID0032811 Css NA 1.097 mg/L 3compartmentss NA 50% Human Human +DTXSID0032811 Css NA 7.566 mg/L 3compartmentss NA 95% Human Human +DTXSID0032811 Css NA 0.8852 mg/L PBTK NA 50% Human Human +DTXSID0032811 Css NA 4.841 mg/L PBTK NA 95% Human Human +DTXSID0032811 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032811 Fup 0.554 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032811 Vd NA 0.6178 L/kg 1compartment NA NA Rat Human DTXSID0032811 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0032811 TK.Half.Life NA 2.937 hours 1compartment NA NA Rat Human -DTXSID0032811 Css NA 0.5404 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032811 Css NA 1.967 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032811 Css NA 0.3796 mg/L PBTK NA 50% Rat Human -DTXSID0032811 Css NA 1.167 mg/L PBTK NA 95% Rat Human -DTXSID0032813 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032813 Fup NA 0.5382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032813 Vd NA 1.745 L/kg 1compartment NA NA Human Human -DTXSID0032813 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0032813 TK.Half.Life NA 28.15 hours 1compartment NA NA Human Human -DTXSID0032813 Css NA 1.65 mg/L 3compartmentss NA 50% Human Human -DTXSID0032813 Css NA 8.716 mg/L 3compartmentss NA 95% Human Human -DTXSID0032813 Css NA 1.4 mg/L PBTK NA 50% Human Human -DTXSID0032813 Css NA 5.774 mg/L PBTK NA 95% Human Human -DTXSID0032813 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032813 Fup NA 0.5382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032813 Vd NA 1.449 L/kg 1compartment NA NA Rat Human +DTXSID0032811 TK.Half.Life NA 2.46 hours 1compartment NA NA Rat Human +DTXSID0032811 Css NA 0.02068 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032811 Css NA 0.1872 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032811 Css NA 0.01607 mg/L PBTK NA 50% Rat Human +DTXSID0032811 Css NA 0.1167 mg/L PBTK NA 95% Rat Human +DTXSID0032813 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032813 Fup 0.506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032813 Vd NA 1.512 L/kg 1compartment NA NA Human Human +DTXSID0032813 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0032813 TK.Half.Life NA 1.521 hours 1compartment NA NA Human Human +DTXSID0032813 Css NA 0.04155 mg/L 3compartmentss NA 50% Human Human +DTXSID0032813 Css NA 0.3484 mg/L 3compartmentss NA 95% Human Human +DTXSID0032813 Css NA 0.03433 mg/L PBTK NA 50% Human Human +DTXSID0032813 Css NA 0.2549 mg/L PBTK NA 95% Human Human +DTXSID0032813 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032813 Fup 0.506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032813 Vd NA 1.277 L/kg 1compartment NA NA Rat Human DTXSID0032813 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0032813 TK.Half.Life NA 6.424 hours 1compartment NA NA Rat Human -DTXSID0032813 Css NA 0.4311 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032813 Css NA 2.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032813 Css NA 0.3568 mg/L PBTK NA 50% Rat Human -DTXSID0032813 Css NA 1.294 mg/L PBTK NA 95% Rat Human -DTXSID0032998 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032998 Fup NA 0.5103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0032998 Vd NA 0.496 L/kg 1compartment NA NA Human Human +DTXSID0032813 TK.Half.Life NA 0.6167 hours 1compartment NA NA Rat Human +DTXSID0032813 Css NA 0.005031 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032813 Css NA 0.03633 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032813 Css NA 0.00425 mg/L PBTK NA 50% Rat Human +DTXSID0032813 Css NA 0.02648 mg/L PBTK NA 95% Rat Human +DTXSID0032998 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032998 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0032998 Vd NA 0.3972 L/kg 1compartment NA NA Human Human DTXSID0032998 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0032998 TK.Half.Life NA 6.29 hours 1compartment NA NA Human Human -DTXSID0032998 Css NA 1.448 mg/L 3compartmentss NA 50% Human Human -DTXSID0032998 Css NA 7.997 mg/L 3compartmentss NA 95% Human Human -DTXSID0032998 Css NA 1.093 mg/L PBTK NA 50% Human Human -DTXSID0032998 Css NA 5.02 mg/L PBTK NA 95% Human Human -DTXSID0032998 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032998 Fup NA 0.5103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0032998 Vd NA 0.5027 L/kg 1compartment NA NA Rat Human +DTXSID0032998 TK.Half.Life NA 6.348 hours 1compartment NA NA Human Human +DTXSID0032998 Css NA 1.836 mg/L 3compartmentss NA 50% Human Human +DTXSID0032998 Css NA 7.744 mg/L 3compartmentss NA 95% Human Human +DTXSID0032998 Css NA 1.29 mg/L PBTK NA 50% Human Human +DTXSID0032998 Css NA 4.761 mg/L PBTK NA 95% Human Human +DTXSID0032998 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032998 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0032998 Vd NA 0.406 L/kg 1compartment NA NA Rat Human DTXSID0032998 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0032998 TK.Half.Life NA 2.172 hours 1compartment NA NA Rat Human -DTXSID0032998 Css NA 0.3936 mg/L 3compartmentss NA 50% Rat Human -DTXSID0032998 Css NA 1.839 mg/L 3compartmentss NA 95% Rat Human -DTXSID0032998 Css NA 0.2822 mg/L PBTK NA 50% Rat Human -DTXSID0032998 Css NA 1.078 mg/L PBTK NA 95% Rat Human -DTXSID0033047 Clint NA 7.113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033047 Fup NA 0.4046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033047 Vd NA 2.137 L/kg 1compartment NA NA Human Human +DTXSID0032998 TK.Half.Life NA 2.211 hours 1compartment NA NA Rat Human +DTXSID0032998 Css NA 0.1172 mg/L 3compartmentss NA 50% Rat Human +DTXSID0032998 Css NA 0.4372 mg/L 3compartmentss NA 95% Rat Human +DTXSID0032998 Css NA 0.08095 mg/L PBTK NA 50% Rat Human +DTXSID0032998 Css NA 0.2624 mg/L PBTK NA 95% Rat Human +DTXSID0033047 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033047 Fup 0.0902 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033047 Vd NA 1.098 L/kg 1compartment NA NA Human Human DTXSID0033047 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0033047 TK.Half.Life NA 5.559 hours 1compartment NA NA Human Human -DTXSID0033047 Css NA 0.2226 mg/L 3compartmentss NA 50% Human Human -DTXSID0033047 Css NA 1.343 mg/L 3compartmentss NA 95% Human Human -DTXSID0033047 Css NA 0.1773 mg/L PBTK NA 50% Human Human -DTXSID0033047 Css NA 0.976 mg/L PBTK NA 95% Human Human -DTXSID0033047 Clint NA 7.113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033047 Fup NA 0.4046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033047 Vd NA 1.689 L/kg 1compartment NA NA Rat Human +DTXSID0033047 TK.Half.Life NA 3.136 hours 1compartment NA NA Human Human +DTXSID0033047 Css NA 0.3228 mg/L 3compartmentss NA 50% Human Human +DTXSID0033047 Css NA 2.56 mg/L 3compartmentss NA 95% Human Human +DTXSID0033047 Css NA 0.208 mg/L PBTK NA 50% Human Human +DTXSID0033047 Css NA 1.574 mg/L PBTK NA 95% Human Human +DTXSID0033047 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033047 Fup 0.0902 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033047 Vd NA 0.8531 L/kg 1compartment NA NA Rat Human DTXSID0033047 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0033047 TK.Half.Life NA 1.843 hours 1compartment NA NA Rat Human -DTXSID0033047 Css NA 0.1151 mg/L 3compartmentss NA 50% Rat Human -DTXSID0033047 Css NA 0.5026 mg/L 3compartmentss NA 95% Rat Human -DTXSID0033047 Css NA 0.0887 mg/L PBTK NA 50% Rat Human -DTXSID0033047 Css NA 0.3494 mg/L PBTK NA 95% Rat Human -DTXSID0033332 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033332 Fup NA 0.0715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033332 Vd NA 0.3031 L/kg 1compartment NA NA Human Human -DTXSID0033332 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID0033332 TK.Half.Life NA 27.55 hours 1compartment NA NA Human Human -DTXSID0033332 Css NA 14.22 mg/L 3compartmentss NA 50% Human Human -DTXSID0033332 Css NA 55.08 mg/L 3compartmentss NA 95% Human Human -DTXSID0033332 Css NA 8.679 mg/L PBTK NA 50% Human Human -DTXSID0033332 Css NA 32.62 mg/L PBTK NA 95% Human Human -DTXSID0033332 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033332 Fup NA 0.0715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033332 Vd NA 0.2798 L/kg 1compartment NA NA Rat Human +DTXSID0033047 TK.Half.Life NA 1.34 hours 1compartment NA NA Rat Human +DTXSID0033047 Css NA 0.04155 mg/L 3compartmentss NA 50% Rat Human +DTXSID0033047 Css NA 0.2537 mg/L 3compartmentss NA 95% Rat Human +DTXSID0033047 Css NA 0.02624 mg/L PBTK NA 50% Rat Human +DTXSID0033047 Css NA 0.1497 mg/L PBTK NA 95% Rat Human +DTXSID0033332 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033332 Fup 0.0683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033332 Vd NA 0.2662 L/kg 1compartment NA NA Human Human +DTXSID0033332 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0033332 TK.Half.Life NA 0.9143 hours 1compartment NA NA Human Human +DTXSID0033332 Css NA 0.2132 mg/L 3compartmentss NA 50% Human Human +DTXSID0033332 Css NA 1.652 mg/L 3compartmentss NA 95% Human Human +DTXSID0033332 Css NA 0.1295 mg/L PBTK NA 50% Human Human +DTXSID0033332 Css NA 0.9787 mg/L PBTK NA 95% Human Human +DTXSID0033332 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033332 Fup 0.0683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033332 Vd NA 0.2523 L/kg 1compartment NA NA Rat Human DTXSID0033332 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0033332 TK.Half.Life NA 8.638 hours 1compartment NA NA Rat Human -DTXSID0033332 Css NA 4.024 mg/L 3compartmentss NA 50% Rat Human -DTXSID0033332 Css NA 13.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID0033332 Css NA 2.292 mg/L PBTK NA 50% Rat Human -DTXSID0033332 Css NA 7.192 mg/L PBTK NA 95% Rat Human -DTXSID0033334 Clint NA 381.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033334 Fup NA 0.0399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033334 Vd NA 0.9607 L/kg 1compartment NA NA Human Human -DTXSID0033334 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0033334 TK.Half.Life NA 1.11 hours 1compartment NA NA Human Human -DTXSID0033334 Css NA 0.04513 mg/L 3compartmentss NA 50% Human Human -DTXSID0033334 Css NA 0.4446 mg/L 3compartmentss NA 95% Human Human -DTXSID0033334 Css NA 0.02821 mg/L PBTK NA 50% Human Human -DTXSID0033334 Css NA 0.2688 mg/L PBTK NA 95% Human Human -DTXSID0033334 Clint NA 381.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033334 Fup NA 0.0399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033334 Vd NA 0.7418 L/kg 1compartment NA NA Rat Human -DTXSID0033334 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0033334 TK.Half.Life NA 0.4111 hours 1compartment NA NA Rat Human -DTXSID0033334 Css NA 0.02613 mg/L 3compartmentss NA 50% Rat Human -DTXSID0033334 Css NA 0.216 mg/L 3compartmentss NA 95% Rat Human -DTXSID0033334 Css NA 0.01522 mg/L PBTK NA 50% Rat Human -DTXSID0033334 Css NA 0.1212 mg/L PBTK NA 95% Rat Human -DTXSID0033382 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033382 Fup NA 0.1552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033382 Vd NA 1.415 L/kg 1compartment NA NA Human Human -DTXSID0033382 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0033382 TK.Half.Life NA 7.923 hours 1compartment NA NA Human Human -DTXSID0033382 Css NA 0.6411 mg/L 3compartmentss NA 50% Human Human -DTXSID0033382 Css NA 4.339 mg/L 3compartmentss NA 95% Human Human -DTXSID0033382 Css NA 0.4836 mg/L PBTK NA 50% Human Human -DTXSID0033382 Css NA 2.839 mg/L PBTK NA 95% Human Human -DTXSID0033382 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033382 Fup NA 0.1552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033382 Vd NA 1.395 L/kg 1compartment NA NA Rat Human +DTXSID0033332 TK.Half.Life NA 0.5307 hours 1compartment NA NA Rat Human +DTXSID0033332 Css NA 0.00225 mg/L 3compartmentss NA 50% Rat Human +DTXSID0033332 Css NA 0.01537 mg/L 3compartmentss NA 95% Rat Human +DTXSID0033332 Css NA 0.001282 mg/L PBTK NA 50% Rat Human +DTXSID0033332 Css NA 0.008583 mg/L PBTK NA 95% Rat Human +DTXSID0033334 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033334 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033334 Vd NA 1.147 L/kg 1compartment NA NA Human Human +DTXSID0033334 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID0033334 TK.Half.Life NA 85.23 hours 1compartment NA NA Human Human +DTXSID0033334 Css NA 9.166 mg/L 3compartmentss NA 50% Human Human +DTXSID0033334 Css NA 42.02 mg/L 3compartmentss NA 95% Human Human +DTXSID0033334 Css NA 6.058 mg/L PBTK NA 50% Human Human +DTXSID0033334 Css NA 25.14 mg/L PBTK NA 95% Human Human +DTXSID0033334 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033334 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033334 Vd NA 0.9154 L/kg 1compartment NA NA Rat Human +DTXSID0033334 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID0033334 TK.Half.Life NA 20.59 hours 1compartment NA NA Rat Human +DTXSID0033334 Css NA 0.221 mg/L 3compartmentss NA 50% Rat Human +DTXSID0033334 Css NA 1.411 mg/L 3compartmentss NA 95% Rat Human +DTXSID0033334 Css NA 0.1417 mg/L PBTK NA 50% Rat Human +DTXSID0033334 Css NA 0.8318 mg/L PBTK NA 95% Rat Human +DTXSID0033382 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033382 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033382 Vd NA 0.6281 L/kg 1compartment NA NA Human Human +DTXSID0033382 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0033382 TK.Half.Life NA 24.57 hours 1compartment NA NA Human Human +DTXSID0033382 Css NA 2.548 mg/L 3compartmentss NA 50% Human Human +DTXSID0033382 Css NA 9.939 mg/L 3compartmentss NA 95% Human Human +DTXSID0033382 Css NA 1.708 mg/L PBTK NA 50% Human Human +DTXSID0033382 Css NA 6.101 mg/L PBTK NA 95% Human Human +DTXSID0033382 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033382 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033382 Vd NA 0.5466 L/kg 1compartment NA NA Rat Human DTXSID0033382 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0033382 TK.Half.Life NA 4.59 hours 1compartment NA NA Rat Human -DTXSID0033382 Css NA 0.3231 mg/L 3compartmentss NA 50% Rat Human -DTXSID0033382 Css NA 1.661 mg/L 3compartmentss NA 95% Rat Human -DTXSID0033382 Css NA 0.232 mg/L PBTK NA 50% Rat Human -DTXSID0033382 Css NA 0.9929 mg/L PBTK NA 95% Rat Human +DTXSID0033382 TK.Half.Life NA 7.106 hours 1compartment NA NA Rat Human +DTXSID0033382 Css NA 0.01375 mg/L 3compartmentss NA 50% Rat Human +DTXSID0033382 Css NA 0.0539 mg/L 3compartmentss NA 95% Rat Human +DTXSID0033382 Css NA 0.008718 mg/L PBTK NA 50% Rat Human +DTXSID0033382 Css NA 0.03175 mg/L PBTK NA 95% Rat Human +DTXSID00334554 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00334554 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00334554 Vd NA 0.7176 L/kg 1compartment NA NA Human Human +DTXSID00334554 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00334554 TK.Half.Life NA 3.181 hours 1compartment NA NA Human Human +DTXSID00334554 Css NA 0.5255 mg/L 3compartmentss NA 50% Human Human +DTXSID00334554 Css NA 3.573 mg/L 3compartmentss NA 95% Human Human +DTXSID00334554 Css NA 0.3488 mg/L PBTK NA 50% Human Human +DTXSID00334554 Css NA 2.231 mg/L PBTK NA 95% Human Human +DTXSID00334554 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00334554 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00334554 Vd NA 0.6099 L/kg 1compartment NA NA Rat Human +DTXSID00334554 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00334554 TK.Half.Life NA 1.57 hours 1compartment NA NA Rat Human +DTXSID00334554 Css NA 0.06409 mg/L 3compartmentss NA 50% Rat Human +DTXSID00334554 Css NA 0.3151 mg/L 3compartmentss NA 95% Rat Human +DTXSID00334554 Css NA 0.04155 mg/L PBTK NA 50% Rat Human +DTXSID00334554 Css NA 0.1896 mg/L PBTK NA 95% Rat Human DTXSID0033469 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0033469 Fup NA 0.3511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033469 Vd NA 0.4286 L/kg 1compartment NA NA Human Human +DTXSID0033469 Vd NA 0.472 L/kg 1compartment NA NA Human Human DTXSID0033469 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0033469 TK.Half.Life NA 7.897 hours 1compartment NA NA Human Human -DTXSID0033469 Css NA 2.17 mg/L 3compartmentss NA 50% Human Human -DTXSID0033469 Css NA 8.744 mg/L 3compartmentss NA 95% Human Human -DTXSID0033469 Css NA 1.514 mg/L PBTK NA 50% Human Human -DTXSID0033469 Css NA 5.416 mg/L PBTK NA 95% Human Human +DTXSID0033469 TK.Half.Life NA 8.706 hours 1compartment NA NA Human Human +DTXSID0033469 Css NA 1.8 mg/L 3compartmentss NA 50% Human Human +DTXSID0033469 Css NA 7.496 mg/L 3compartmentss NA 95% Human Human +DTXSID0033469 Css NA 1.277 mg/L PBTK NA 50% Human Human +DTXSID0033469 Css NA 4.686 mg/L PBTK NA 95% Human Human DTXSID0033469 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0033469 Fup NA 0.3511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033469 Vd NA 0.4468 L/kg 1compartment NA NA Rat Human +DTXSID0033469 Vd NA 0.484 L/kg 1compartment NA NA Rat Human DTXSID0033469 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0033469 TK.Half.Life NA 2.805 hours 1compartment NA NA Rat Human -DTXSID0033469 Css NA 0.5968 mg/L 3compartmentss NA 50% Rat Human -DTXSID0033469 Css NA 2.076 mg/L 3compartmentss NA 95% Rat Human -DTXSID0033469 Css NA 0.3959 mg/L PBTK NA 50% Rat Human -DTXSID0033469 Css NA 1.205 mg/L PBTK NA 95% Rat Human -DTXSID0033673 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033673 Fup NA 0.7763 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033673 Vd NA 0.8266 L/kg 1compartment NA NA Human Human +DTXSID0033469 TK.Half.Life NA 3.041 hours 1compartment NA NA Rat Human +DTXSID0033469 Css NA 0.03253 mg/L 3compartmentss NA 50% Rat Human +DTXSID0033469 Css NA 0.2 mg/L 3compartmentss NA 95% Rat Human +DTXSID0033469 Css NA 0.02241 mg/L PBTK NA 50% Rat Human +DTXSID0033469 Css NA 0.1243 mg/L PBTK NA 95% Rat Human +DTXSID0033673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033673 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033673 Vd NA 0.8005 L/kg 1compartment NA NA Human Human DTXSID0033673 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0033673 TK.Half.Life NA 6.948 hours 1compartment NA NA Human Human -DTXSID0033673 Css NA 0.9934 mg/L 3compartmentss NA 50% Human Human -DTXSID0033673 Css NA 6.093 mg/L 3compartmentss NA 95% Human Human -DTXSID0033673 Css NA 0.8326 mg/L PBTK NA 50% Human Human -DTXSID0033673 Css NA 3.948 mg/L PBTK NA 95% Human Human -DTXSID0033673 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033673 Fup NA 0.7763 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033673 Vd NA 0.8274 L/kg 1compartment NA NA Rat Human +DTXSID0033673 TK.Half.Life NA 0.7072 hours 1compartment NA NA Human Human +DTXSID0033673 Css NA 0.02534 mg/L 3compartmentss NA 50% Human Human +DTXSID0033673 Css NA 0.2966 mg/L 3compartmentss NA 95% Human Human +DTXSID0033673 Css NA 0.02044 mg/L PBTK NA 50% Human Human +DTXSID0033673 Css NA 0.2077 mg/L PBTK NA 95% Human Human +DTXSID0033673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033673 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033673 Vd NA 0.7845 L/kg 1compartment NA NA Rat Human DTXSID0033673 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0033673 TK.Half.Life NA 2.355 hours 1compartment NA NA Rat Human -DTXSID0033673 Css NA 0.2556 mg/L 3compartmentss NA 50% Rat Human -DTXSID0033673 Css NA 1.604 mg/L 3compartmentss NA 95% Rat Human -DTXSID0033673 Css NA 0.2072 mg/L PBTK NA 50% Rat Human -DTXSID0033673 Css NA 0.9598 mg/L PBTK NA 95% Rat Human -DTXSID0033754 Clint NA 0.02431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033754 Fup NA 0.914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0033754 Vd NA 1.038 L/kg 1compartment NA NA Human Human +DTXSID0033673 TK.Half.Life NA 0.3423 hours 1compartment NA NA Rat Human +DTXSID0033673 Css NA 0.0009079 mg/L 3compartmentss NA 50% Rat Human +DTXSID0033673 Css NA 0.01201 mg/L 3compartmentss NA 95% Rat Human +DTXSID0033673 Css NA 0.0007222 mg/L PBTK NA 50% Rat Human +DTXSID0033673 Css NA 0.008116 mg/L PBTK NA 95% Rat Human +DTXSID0033754 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033754 Fup 0.883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0033754 Vd NA 0.9677 L/kg 1compartment NA NA Human Human DTXSID0033754 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0033754 TK.Half.Life NA 7.207 hours 1compartment NA NA Human Human -DTXSID0033754 Css NA 0.7951 mg/L 3compartmentss NA 50% Human Human -DTXSID0033754 Css NA 3.24 mg/L 3compartmentss NA 95% Human Human -DTXSID0033754 Css NA 0.7062 mg/L PBTK NA 50% Human Human -DTXSID0033754 Css NA 2.305 mg/L PBTK NA 95% Human Human -DTXSID0033754 Clint NA 0.02431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033754 Fup NA 0.914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0033754 Vd NA 1.021 L/kg 1compartment NA NA Rat Human +DTXSID0033754 TK.Half.Life NA 7.193 hours 1compartment NA NA Human Human +DTXSID0033754 Css NA 0.7667 mg/L 3compartmentss NA 50% Human Human +DTXSID0033754 Css NA 4.348 mg/L 3compartmentss NA 95% Human Human +DTXSID0033754 Css NA 0.665 mg/L PBTK NA 50% Human Human +DTXSID0033754 Css NA 2.905 mg/L PBTK NA 95% Human Human +DTXSID0033754 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033754 Fup 0.883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0033754 Vd NA 0.961 L/kg 1compartment NA NA Rat Human DTXSID0033754 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0033754 TK.Half.Life NA 2.428 hours 1compartment NA NA Rat Human -DTXSID0033754 Css NA 0.2057 mg/L 3compartmentss NA 50% Rat Human -DTXSID0033754 Css NA 0.7526 mg/L 3compartmentss NA 95% Rat Human -DTXSID0033754 Css NA 0.1799 mg/L PBTK NA 50% Rat Human -DTXSID0033754 Css NA 0.4974 mg/L PBTK NA 95% Rat Human +DTXSID0033754 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human +DTXSID0033754 Css NA 0.01387 mg/L 3compartmentss NA 50% Rat Human +DTXSID0033754 Css NA 0.1074 mg/L 3compartmentss NA 95% Rat Human +DTXSID0033754 Css NA 0.01169 mg/L PBTK NA 50% Rat Human +DTXSID0033754 Css NA 0.07367 mg/L PBTK NA 95% Rat Human DTXSID0033960 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0033960 Fup 0.29 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0033960 Vd NA 3.185 L/kg 1compartment NA NA Human Human -DTXSID0033960 Days.Css NA 297 Days PBTK NA NA Human Human +DTXSID0033960 Days.Css NA 296 Days PBTK NA NA Human Human DTXSID0033960 TK.Half.Life NA 1158 hours 1compartment NA NA Human Human -DTXSID0033960 Css NA 34.9 mg/L 3compartmentss NA 50% Human Human -DTXSID0033960 Css NA 103.5 mg/L 3compartmentss NA 95% Human Human -DTXSID0033960 Css NA 28.86 mg/L PBTK NA 50% Human Human -DTXSID0033960 Css NA 75.74 mg/L PBTK NA 95% Human Human +DTXSID0033960 Css NA 29.88 mg/L 3compartmentss NA 50% Human Human +DTXSID0033960 Css NA 89.67 mg/L 3compartmentss NA 95% Human Human +DTXSID0033960 Css NA 24.8 mg/L PBTK NA 50% Human Human +DTXSID0033960 Css NA 65.94 mg/L PBTK NA 95% Human Human DTXSID0033960 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID0033960 Fup 0.29 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0033960 Vd NA 2.461 L/kg 1compartment NA NA Rat Human DTXSID0033960 Days.Css NA 75 Days PBTK NA NA Rat Human DTXSID0033960 TK.Half.Life NA 86.9 hours 1compartment NA NA Rat Human -DTXSID0033960 Css NA 9.277 mg/L 3compartmentss NA 50% Rat Human -DTXSID0033960 Css NA 22.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID0033960 Css NA 7.501 mg/L PBTK NA 50% Rat Human -DTXSID0033960 Css NA 14.9 mg/L PBTK NA 95% Rat Human +DTXSID0033960 Css NA 0.719 mg/L 3compartmentss NA 50% Rat Human +DTXSID0033960 Css NA 3.029 mg/L 3compartmentss NA 95% Rat Human +DTXSID0033960 Css NA 0.5858 mg/L PBTK NA 50% Rat Human +DTXSID0033960 Css NA 2.239 mg/L PBTK NA 95% Rat Human +DTXSID00341081 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00341081 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00341081 Vd NA 1.496 L/kg 1compartment NA NA Human Human +DTXSID00341081 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00341081 TK.Half.Life NA 2.305 hours 1compartment NA NA Human Human +DTXSID00341081 Css NA 0.095 mg/L 3compartmentss NA 50% Human Human +DTXSID00341081 Css NA 0.668 mg/L 3compartmentss NA 95% Human Human +DTXSID00341081 Css NA 0.06988 mg/L PBTK NA 50% Human Human +DTXSID00341081 Css NA 0.4632 mg/L PBTK NA 95% Human Human +DTXSID00341081 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00341081 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00341081 Vd NA 1.196 L/kg 1compartment NA NA Rat Human +DTXSID00341081 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00341081 TK.Half.Life NA 0.909 hours 1compartment NA NA Rat Human +DTXSID00341081 Css NA 0.01188 mg/L 3compartmentss NA 50% Rat Human +DTXSID00341081 Css NA 0.06127 mg/L 3compartmentss NA 95% Rat Human +DTXSID00341081 Css NA 0.008724 mg/L PBTK NA 50% Rat Human +DTXSID00341081 Css NA 0.04204 mg/L PBTK NA 95% Rat Human +DTXSID00341147 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00341147 Fup 0.0556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00341147 Vd NA 1.467 L/kg 1compartment NA NA Human Human +DTXSID00341147 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00341147 TK.Half.Life NA 6.33 hours 1compartment NA NA Human Human +DTXSID00341147 Css NA 0.5619 mg/L 3compartmentss NA 50% Human Human +DTXSID00341147 Css NA 4.3 mg/L 3compartmentss NA 95% Human Human +DTXSID00341147 Css NA 0.3606 mg/L PBTK NA 50% Human Human +DTXSID00341147 Css NA 2.648 mg/L PBTK NA 95% Human Human +DTXSID00341147 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00341147 Fup 0.0556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00341147 Vd NA 1.106 L/kg 1compartment NA NA Rat Human +DTXSID00341147 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00341147 TK.Half.Life NA 2.465 hours 1compartment NA NA Rat Human +DTXSID00341147 Css NA 0.0728 mg/L 3compartmentss NA 50% Rat Human +DTXSID00341147 Css NA 0.4368 mg/L 3compartmentss NA 95% Rat Human +DTXSID00341147 Css NA 0.04559 mg/L PBTK NA 50% Rat Human +DTXSID00341147 Css NA 0.2642 mg/L PBTK NA 95% Rat Human DTXSID0034192 Clint 37.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0034192 Fup 0.0999 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0034192 Vd NA 1.825 L/kg 1compartment NA NA Human Human +DTXSID0034192 Vd NA 1.284 L/kg 1compartment NA NA Human Human DTXSID0034192 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0034192 TK.Half.Life NA 3.947 hours 1compartment NA NA Human Human -DTXSID0034192 Css NA 0.1738 mg/L 3compartmentss NA 50% Human Human -DTXSID0034192 Css NA 1.061 mg/L 3compartmentss NA 95% Human Human -DTXSID0034192 Css NA 0.1182 mg/L PBTK NA 50% Human Human -DTXSID0034192 Css NA 0.7099 mg/L PBTK NA 95% Human Human +DTXSID0034192 TK.Half.Life NA 2.505 hours 1compartment NA NA Human Human +DTXSID0034192 Css NA 0.1405 mg/L 3compartmentss NA 50% Human Human +DTXSID0034192 Css NA 0.9626 mg/L 3compartmentss NA 95% Human Human +DTXSID0034192 Css NA 0.09354 mg/L PBTK NA 50% Human Human +DTXSID0034192 Css NA 0.6092 mg/L PBTK NA 95% Human Human DTXSID0034192 Clint 37.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0034192 Fup 0.0999 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0034192 Vd NA 1.386 L/kg 1compartment NA NA Rat Human +DTXSID0034192 Vd NA 0.9918 L/kg 1compartment NA NA Rat Human DTXSID0034192 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0034192 TK.Half.Life NA 1.387 hours 1compartment NA NA Rat Human -DTXSID0034192 Css NA 0.09638 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034192 Css NA 0.4827 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034192 Css NA 0.06264 mg/L PBTK NA 50% Rat Human -DTXSID0034192 Css NA 0.3004 mg/L PBTK NA 95% Rat Human +DTXSID0034192 TK.Half.Life NA 0.9989 hours 1compartment NA NA Rat Human +DTXSID0034192 Css NA 0.0183 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034192 Css NA 0.09285 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034192 Css NA 0.01195 mg/L PBTK NA 50% Rat Human +DTXSID0034192 Css NA 0.05982 mg/L PBTK NA 95% Rat Human DTXSID0034223 Clint 15.94 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID0034223 Fup NA 0.0286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034223 Vd NA 2.928 L/kg 1compartment NA NA Human Human +DTXSID0034223 Fup 0.0296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034223 Vd NA 2.935 L/kg 1compartment NA NA Human Human DTXSID0034223 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID0034223 TK.Half.Life NA 60.8 hours 1compartment NA NA Human Human -DTXSID0034223 Css NA 2.724 mg/L 3compartmentss NA 50% Human Human -DTXSID0034223 Css NA 17.12 mg/L 3compartmentss NA 95% Human Human -DTXSID0034223 Css NA 1.861 mg/L PBTK NA 50% Human Human -DTXSID0034223 Css NA 11.25 mg/L PBTK NA 95% Human Human +DTXSID0034223 TK.Half.Life NA 60.75 hours 1compartment NA NA Human Human +DTXSID0034223 Css NA 2.633 mg/L 3compartmentss NA 50% Human Human +DTXSID0034223 Css NA 17.71 mg/L 3compartmentss NA 95% Human Human +DTXSID0034223 Css NA 1.806 mg/L PBTK NA 50% Human Human +DTXSID0034223 Css NA 11.7 mg/L PBTK NA 95% Human Human DTXSID0034223 Clint 15.94 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID0034223 Fup NA 0.0286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034223 Vd NA 2.192 L/kg 1compartment NA NA Rat Human +DTXSID0034223 Fup 0.0296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034223 Vd NA 2.197 L/kg 1compartment NA NA Rat Human DTXSID0034223 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID0034223 TK.Half.Life NA 10.45 hours 1compartment NA NA Rat Human -DTXSID0034223 Css NA 1.505 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034223 Css NA 7.837 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034223 Css NA 0.9816 mg/L PBTK NA 50% Rat Human -DTXSID0034223 Css NA 4.931 mg/L PBTK NA 95% Rat Human +DTXSID0034223 TK.Half.Life NA 10.37 hours 1compartment NA NA Rat Human +DTXSID0034223 Css NA 0.3403 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034223 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034223 Css NA 0.23 mg/L PBTK NA 50% Rat Human +DTXSID0034223 Css NA 1.183 mg/L PBTK NA 95% Rat Human DTXSID0034227 Clint 12.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0034227 Fup 0.2842 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID0034227 Vd NA 3.137 L/kg 1compartment NA NA Human Human +DTXSID0034227 Vd NA 2.587 L/kg 1compartment NA NA Human Human DTXSID0034227 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0034227 TK.Half.Life NA 4.34 hours 1compartment NA NA Human Human -DTXSID0034227 Css NA 0.0759 mg/L 3compartmentss NA 50% Human Human -DTXSID0034227 Css NA 0.6025 mg/L 3compartmentss NA 95% Human Human -DTXSID0034227 Css NA 0.0837 mg/L PBTK NA 50% Human Human -DTXSID0034227 Css NA 0.5306 mg/L PBTK NA 95% Human Human +DTXSID0034227 TK.Half.Life NA 3.786 hours 1compartment NA NA Human Human +DTXSID0034227 Css NA 0.0819 mg/L 3compartmentss NA 50% Human Human +DTXSID0034227 Css NA 0.6431 mg/L 3compartmentss NA 95% Human Human +DTXSID0034227 Css NA 0.08151 mg/L PBTK NA 50% Human Human +DTXSID0034227 Css NA 0.5278 mg/L PBTK NA 95% Human Human DTXSID0034227 Clint 12.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0034227 Fup 0.2842 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID0034227 Vd NA 3.176 L/kg 1compartment NA NA Rat Human +DTXSID0034227 Vd NA 2.614 L/kg 1compartment NA NA Rat Human DTXSID0034227 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0034227 TK.Half.Life NA 2.539 hours 1compartment NA NA Rat Human -DTXSID0034227 Css NA 0.03884 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034227 Css NA 0.2396 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034227 Css NA 0.04238 mg/L PBTK NA 50% Rat Human -DTXSID0034227 Css NA 0.1994 mg/L PBTK NA 95% Rat Human -DTXSID0034229 Clint NA 0.0417 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034229 Fup NA 0.33 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034229 Vd NA 2.124 L/kg 1compartment NA NA Human Human -DTXSID0034229 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID0034229 TK.Half.Life NA 70.82 hours 1compartment NA NA Human Human -DTXSID0034229 Css NA 3.496 mg/L 3compartmentss NA 50% Human Human -DTXSID0034229 Css NA 12.08 mg/L 3compartmentss NA 95% Human Human -DTXSID0034229 Css NA 2.724 mg/L PBTK NA 50% Human Human -DTXSID0034229 Css NA 8.085 mg/L PBTK NA 95% Human Human -DTXSID0034229 Clint NA 0.0417 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034229 Fup NA 0.33 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034229 Vd NA 1.664 L/kg 1compartment NA NA Rat Human -DTXSID0034229 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0034229 TK.Half.Life NA 12.84 hours 1compartment NA NA Rat Human -DTXSID0034229 Css NA 0.996 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034229 Css NA 2.867 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034229 Css NA 0.744 mg/L PBTK NA 50% Rat Human -DTXSID0034229 Css NA 1.794 mg/L PBTK NA 95% Rat Human +DTXSID0034227 TK.Half.Life NA 2.211 hours 1compartment NA NA Rat Human +DTXSID0034227 Css NA 0.009768 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034227 Css NA 0.06068 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034227 Css NA 0.01011 mg/L PBTK NA 50% Rat Human +DTXSID0034227 Css NA 0.05035 mg/L PBTK NA 95% Rat Human +DTXSID0034229 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034229 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034229 Vd NA 2.036 L/kg 1compartment NA NA Human Human +DTXSID0034229 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0034229 TK.Half.Life NA 3.111 hours 1compartment NA NA Human Human +DTXSID0034229 Css NA 0.093 mg/L 3compartmentss NA 50% Human Human +DTXSID0034229 Css NA 0.6528 mg/L 3compartmentss NA 95% Human Human +DTXSID0034229 Css NA 0.07087 mg/L PBTK NA 50% Human Human +DTXSID0034229 Css NA 0.4588 mg/L PBTK NA 95% Human Human +DTXSID0034229 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034229 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034229 Vd NA 1.598 L/kg 1compartment NA NA Rat Human +DTXSID0034229 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0034229 TK.Half.Life NA 1.076 hours 1compartment NA NA Rat Human +DTXSID0034229 Css NA 0.01163 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034229 Css NA 0.0619 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034229 Css NA 0.008961 mg/L PBTK NA 50% Rat Human +DTXSID0034229 Css NA 0.0437 mg/L PBTK NA 95% Rat Human +DTXSID00342871 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00342871 Fup 0.0149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00342871 Vd NA 2.79 L/kg 1compartment NA NA Human Human +DTXSID00342871 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID00342871 TK.Half.Life NA 48.64 hours 1compartment NA NA Human Human +DTXSID00342871 Css NA 2.306 mg/L 3compartmentss NA 50% Human Human +DTXSID00342871 Css NA 16.13 mg/L 3compartmentss NA 95% Human Human +DTXSID00342871 Css NA 1.555 mg/L PBTK NA 50% Human Human +DTXSID00342871 Css NA 10.35 mg/L PBTK NA 95% Human Human +DTXSID00342871 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00342871 Fup 0.0149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00342871 Vd NA 2.085 L/kg 1compartment NA NA Rat Human +DTXSID00342871 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID00342871 TK.Half.Life NA 9.59 hours 1compartment NA NA Rat Human +DTXSID00342871 Css NA 0.3 mg/L 3compartmentss NA 50% Rat Human +DTXSID00342871 Css NA 1.746 mg/L 3compartmentss NA 95% Rat Human +DTXSID00342871 Css NA 0.1985 mg/L PBTK NA 50% Rat Human +DTXSID00342871 Css NA 1.12 mg/L PBTK NA 95% Rat Human DTXSID0034300 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0034300 Fup 0.5732 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0034300 Vd NA 1.669 L/kg 1compartment NA NA Human Human DTXSID0034300 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID0034300 TK.Half.Life NA 24.17 hours 1compartment NA NA Human Human -DTXSID0034300 Css NA 1.473 mg/L 3compartmentss NA 50% Human Human -DTXSID0034300 Css NA 9.199 mg/L 3compartmentss NA 95% Human Human -DTXSID0034300 Css NA 1.274 mg/L PBTK NA 50% Human Human -DTXSID0034300 Css NA 5.964 mg/L PBTK NA 95% Human Human +DTXSID0034300 Css NA 1.434 mg/L 3compartmentss NA 50% Human Human +DTXSID0034300 Css NA 8.899 mg/L 3compartmentss NA 95% Human Human +DTXSID0034300 Css NA 1.24 mg/L PBTK NA 50% Human Human +DTXSID0034300 Css NA 5.906 mg/L PBTK NA 95% Human Human DTXSID0034300 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0034300 Fup 0.5732 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0034300 Vd NA 1.404 L/kg 1compartment NA NA Rat Human DTXSID0034300 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0034300 TK.Half.Life NA 5.767 hours 1compartment NA NA Rat Human -DTXSID0034300 Css NA 0.3889 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034300 Css NA 2.169 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034300 Css NA 0.3254 mg/L PBTK NA 50% Rat Human -DTXSID0034300 Css NA 1.329 mg/L PBTK NA 95% Rat Human -DTXSID0034518 Clint NA 56.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034518 Fup NA 0.0298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034518 Vd NA 1.486 L/kg 1compartment NA NA Human Human -DTXSID0034518 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0034518 TK.Half.Life NA 4.787 hours 1compartment NA NA Human Human -DTXSID0034518 Css NA 0.4066 mg/L 3compartmentss NA 50% Human Human -DTXSID0034518 Css NA 3.683 mg/L 3compartmentss NA 95% Human Human -DTXSID0034518 Css NA 0.2552 mg/L PBTK NA 50% Human Human -DTXSID0034518 Css NA 2.249 mg/L PBTK NA 95% Human Human -DTXSID0034518 Clint NA 56.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034518 Fup NA 0.0298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034518 Vd NA 1.107 L/kg 1compartment NA NA Rat Human +DTXSID0034300 Css NA 0.08811 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034300 Css NA 0.5171 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034300 Css NA 0.07635 mg/L PBTK NA 50% Rat Human +DTXSID0034300 Css NA 0.3264 mg/L PBTK NA 95% Rat Human +DTXSID0034518 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034518 Fup 0.0172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034518 Vd NA 1.155 L/kg 1compartment NA NA Human Human +DTXSID0034518 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0034518 TK.Half.Life NA 11.55 hours 1compartment NA NA Human Human +DTXSID0034518 Css NA 1.614 mg/L 3compartmentss NA 50% Human Human +DTXSID0034518 Css NA 15.21 mg/L 3compartmentss NA 95% Human Human +DTXSID0034518 Css NA 0.9866 mg/L PBTK NA 50% Human Human +DTXSID0034518 Css NA 9.028 mg/L PBTK NA 95% Human Human +DTXSID0034518 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034518 Fup 0.0172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034518 Vd NA 0.8552 L/kg 1compartment NA NA Rat Human DTXSID0034518 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0034518 TK.Half.Life NA 1.815 hours 1compartment NA NA Rat Human -DTXSID0034518 Css NA 0.2324 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034518 Css NA 1.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034518 Css NA 0.1373 mg/L PBTK NA 50% Rat Human -DTXSID0034518 Css NA 0.9778 mg/L PBTK NA 95% Rat Human +DTXSID0034518 TK.Half.Life NA 4.878 hours 1compartment NA NA Rat Human +DTXSID0034518 Css NA 0.2124 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034518 Css NA 1.639 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034518 Css NA 0.1256 mg/L PBTK NA 50% Rat Human +DTXSID0034518 Css NA 0.9448 mg/L PBTK NA 95% Rat Human DTXSID0034566 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0034566 Fup 0.001379 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID0034566 Vd NA 0.4753 L/kg 1compartment NA NA Human Human -DTXSID0034566 Days.Css NA 619 Days PBTK NA NA Human Human -DTXSID0034566 TK.Half.Life NA 2270 hours 1compartment NA NA Human Human -DTXSID0034566 Css NA 804.8 mg/L 3compartmentss NA 50% Human Human -DTXSID0034566 Css NA 4415 mg/L 3compartmentss NA 95% Human Human -DTXSID0034566 Css NA 474.6 mg/L PBTK NA 50% Human Human -DTXSID0034566 Css NA 2599 mg/L PBTK NA 95% Human Human +DTXSID0034566 Vd NA 2.005 L/kg 1compartment NA NA Human Human +DTXSID0034566 Days.Css NA 5203 Days PBTK NA NA Human Human +DTXSID0034566 TK.Half.Life NA 18880 hours 1compartment NA NA Human Human +DTXSID0034566 Css NA 1191 mg/L 3compartmentss NA 50% Human Human +DTXSID0034566 Css NA 4938 mg/L 3compartmentss NA 95% Human Human +DTXSID0034566 Css NA 754.8 mg/L PBTK NA 50% Human Human +DTXSID0034566 Css NA 2968 mg/L PBTK NA 95% Human Human DTXSID0034566 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0034566 Fup 0.001379 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID0034566 Vd NA 0.4063 L/kg 1compartment NA NA Rat Human -DTXSID0034566 Days.Css NA 173 Days PBTK NA NA Rat Human -DTXSID0034566 TK.Half.Life NA 652.7 hours 1compartment NA NA Rat Human -DTXSID0034566 Css NA 230.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034566 Css NA 1147 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034566 Css NA 127.2 mg/L PBTK NA 50% Rat Human -DTXSID0034566 Css NA 622.3 mg/L PBTK NA 95% Rat Human -DTXSID0034695 Clint NA 2.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034695 Fup NA 0.6137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034695 Vd NA 0.5298 L/kg 1compartment NA NA Human Human -DTXSID0034695 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0034695 TK.Half.Life NA 1.494 hours 1compartment NA NA Human Human -DTXSID0034695 Css NA 0.304 mg/L 3compartmentss NA 50% Human Human -DTXSID0034695 Css NA 2.332 mg/L 3compartmentss NA 95% Human Human -DTXSID0034695 Css NA 0.227 mg/L PBTK NA 50% Human Human -DTXSID0034695 Css NA 1.463 mg/L PBTK NA 95% Human Human -DTXSID0034695 Clint NA 2.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034695 Fup NA 0.6137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034695 Vd NA 0.538 L/kg 1compartment NA NA Rat Human -DTXSID0034695 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0034695 TK.Half.Life NA 0.7933 hours 1compartment NA NA Rat Human -DTXSID0034695 Css NA 0.1328 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034695 Css NA 0.9184 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034695 Css NA 0.09512 mg/L PBTK NA 50% Rat Human -DTXSID0034695 Css NA 0.5302 mg/L PBTK NA 95% Rat Human -DTXSID0034722 Clint NA 0.5463 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034722 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034722 Vd NA 0.2258 L/kg 1compartment NA NA Human Human -DTXSID0034722 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0034722 TK.Half.Life NA 21.24 hours 1compartment NA NA Human Human -DTXSID0034722 Css NA 16.79 mg/L 3compartmentss NA 50% Human Human -DTXSID0034722 Css NA 82.05 mg/L 3compartmentss NA 95% Human Human -DTXSID0034722 Css NA 9.979 mg/L PBTK NA 50% Human Human -DTXSID0034722 Css NA 47.46 mg/L PBTK NA 95% Human Human -DTXSID0034722 Clint NA 0.5463 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034722 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034722 Vd NA 0.2161 L/kg 1compartment NA NA Rat Human +DTXSID0034566 Vd NA 1.479 L/kg 1compartment NA NA Rat Human +DTXSID0034566 Days.Css NA 1302 Days PBTK NA NA Rat Human +DTXSID0034566 TK.Half.Life NA 2932 hours 1compartment NA NA Rat Human +DTXSID0034566 Css NA 21.62 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034566 Css NA 126.3 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034566 Css NA 13.01 mg/L PBTK NA 50% Rat Human +DTXSID0034566 Css NA 73.61 mg/L PBTK NA 95% Rat Human +DTXSID0034722 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034722 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034722 Vd NA 2.491 L/kg 1compartment NA NA Human Human +DTXSID0034722 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0034722 TK.Half.Life NA 18.18 hours 1compartment NA NA Human Human +DTXSID0034722 Css NA 0.7717 mg/L 3compartmentss NA 50% Human Human +DTXSID0034722 Css NA 4.243 mg/L 3compartmentss NA 95% Human Human +DTXSID0034722 Css NA 0.5583 mg/L PBTK NA 50% Human Human +DTXSID0034722 Css NA 2.947 mg/L PBTK NA 95% Human Human +DTXSID0034722 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034722 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034722 Vd NA 1.897 L/kg 1compartment NA NA Rat Human DTXSID0034722 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0034722 TK.Half.Life NA 9.161 hours 1compartment NA NA Rat Human -DTXSID0034722 Css NA 6.392 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034722 Css NA 26.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034722 Css NA 3.539 mg/L PBTK NA 50% Rat Human -DTXSID0034722 Css NA 14.55 mg/L PBTK NA 95% Rat Human -DTXSID0034776 Clint NA 213.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034776 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034776 Vd NA 2.707 L/kg 1compartment NA NA Human Human -DTXSID0034776 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0034776 TK.Half.Life NA 6.62 hours 1compartment NA NA Human Human -DTXSID0034776 Css NA 0.2369 mg/L 3compartmentss NA 50% Human Human -DTXSID0034776 Css NA 1.629 mg/L 3compartmentss NA 95% Human Human -DTXSID0034776 Css NA 0.1585 mg/L PBTK NA 50% Human Human -DTXSID0034776 Css NA 1.047 mg/L PBTK NA 95% Human Human -DTXSID0034776 Clint NA 213.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034776 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034776 Vd NA 2.021 L/kg 1compartment NA NA Rat Human -DTXSID0034776 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0034776 TK.Half.Life NA 1.641 hours 1compartment NA NA Rat Human -DTXSID0034776 Css NA 0.1318 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034776 Css NA 0.8147 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034776 Css NA 0.08384 mg/L PBTK NA 50% Rat Human -DTXSID0034776 Css NA 0.491 mg/L PBTK NA 95% Rat Human +DTXSID0034722 TK.Half.Life NA 4.615 hours 1compartment NA NA Rat Human +DTXSID0034722 Css NA 0.0937 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034722 Css NA 0.3549 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034722 Css NA 0.0675 mg/L PBTK NA 50% Rat Human +DTXSID0034722 Css NA 0.2445 mg/L PBTK NA 95% Rat Human +DTXSID0034776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034776 Fup 0.00988 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034776 Vd NA 2.546 L/kg 1compartment NA NA Human Human +DTXSID0034776 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0034776 TK.Half.Life NA 46.06 hours 1compartment NA NA Human Human +DTXSID0034776 Css NA 2.538 mg/L 3compartmentss NA 50% Human Human +DTXSID0034776 Css NA 18.68 mg/L 3compartmentss NA 95% Human Human +DTXSID0034776 Css NA 1.682 mg/L PBTK NA 50% Human Human +DTXSID0034776 Css NA 11.82 mg/L PBTK NA 95% Human Human +DTXSID0034776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034776 Fup 0.00988 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034776 Vd NA 1.897 L/kg 1compartment NA NA Rat Human +DTXSID0034776 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID0034776 TK.Half.Life NA 10.92 hours 1compartment NA NA Rat Human +DTXSID0034776 Css NA 0.3308 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034776 Css NA 2.086 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034776 Css NA 0.2136 mg/L PBTK NA 50% Rat Human +DTXSID0034776 Css NA 1.295 mg/L PBTK NA 95% Rat Human DTXSID0034803 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0034803 Fup 0.01009 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID0034803 Vd NA 0.2193 L/kg 1compartment NA NA Human Human -DTXSID0034803 Days.Css NA 32 Days PBTK NA NA Human Human -DTXSID0034803 TK.Half.Life NA 141 hours 1compartment NA NA Human Human -DTXSID0034803 Css NA 112 mg/L 3compartmentss NA 50% Human Human -DTXSID0034803 Css NA 673.1 mg/L 3compartmentss NA 95% Human Human -DTXSID0034803 Css NA 65.59 mg/L PBTK NA 50% Human Human -DTXSID0034803 Css NA 386.3 mg/L PBTK NA 95% Human Human +DTXSID0034803 Vd NA 0.1659 L/kg 1compartment NA NA Human Human +DTXSID0034803 Days.Css NA 23 Days PBTK NA NA Human Human +DTXSID0034803 TK.Half.Life NA 106.4 hours 1compartment NA NA Human Human +DTXSID0034803 Css NA 74.57 mg/L 3compartmentss NA 50% Human Human +DTXSID0034803 Css NA 496.1 mg/L 3compartmentss NA 95% Human Human +DTXSID0034803 Css NA 43.64 mg/L PBTK NA 50% Human Human +DTXSID0034803 Css NA 282.9 mg/L PBTK NA 95% Human Human DTXSID0034803 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0034803 Fup 0.01009 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID0034803 Vd NA 0.1978 L/kg 1compartment NA NA Rat Human -DTXSID0034803 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID0034803 TK.Half.Life NA 43.27 hours 1compartment NA NA Rat Human -DTXSID0034803 Css NA 31.64 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034803 Css NA 169.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034803 Css NA 17.24 mg/L PBTK NA 50% Rat Human -DTXSID0034803 Css NA 91.91 mg/L PBTK NA 95% Rat Human -DTXSID0034851 Clint NA 0.0319 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034851 Fup NA 0.0227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034851 Vd NA 0.2428 L/kg 1compartment NA NA Human Human -DTXSID0034851 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID0034851 TK.Half.Life NA 65.76 hours 1compartment NA NA Human Human -DTXSID0034851 Css NA 45.55 mg/L 3compartmentss NA 50% Human Human -DTXSID0034851 Css NA 293.4 mg/L 3compartmentss NA 95% Human Human -DTXSID0034851 Css NA 27.22 mg/L PBTK NA 50% Human Human -DTXSID0034851 Css NA 170.4 mg/L PBTK NA 95% Human Human -DTXSID0034851 Clint NA 0.0319 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034851 Fup NA 0.0227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034851 Vd NA 0.237 L/kg 1compartment NA NA Rat Human -DTXSID0034851 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0034851 TK.Half.Life NA 22.45 hours 1compartment NA NA Rat Human -DTXSID0034851 Css NA 13.42 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034851 Css NA 75.69 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034851 Css NA 7.471 mg/L PBTK NA 50% Rat Human -DTXSID0034851 Css NA 41.1 mg/L PBTK NA 95% Rat Human +DTXSID0034803 Vd NA 0.1647 L/kg 1compartment NA NA Rat Human +DTXSID0034803 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID0034803 TK.Half.Life NA 35.99 hours 1compartment NA NA Rat Human +DTXSID0034803 Css NA 0.5592 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034803 Css NA 4.4 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034803 Css NA 0.3041 mg/L PBTK NA 50% Rat Human +DTXSID0034803 Css NA 2.388 mg/L PBTK NA 95% Rat Human +DTXSID0034851 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034851 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034851 Vd NA 0.3527 L/kg 1compartment NA NA Human Human +DTXSID0034851 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0034851 TK.Half.Life NA 1.967 hours 1compartment NA NA Human Human +DTXSID0034851 Css NA 0.764 mg/L 3compartmentss NA 50% Human Human +DTXSID0034851 Css NA 5.082 mg/L 3compartmentss NA 95% Human Human +DTXSID0034851 Css NA 0.4848 mg/L PBTK NA 50% Human Human +DTXSID0034851 Css NA 3.089 mg/L PBTK NA 95% Human Human +DTXSID0034851 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034851 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034851 Vd NA 0.3511 L/kg 1compartment NA NA Rat Human +DTXSID0034851 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0034851 TK.Half.Life NA 1.187 hours 1compartment NA NA Rat Human +DTXSID0034851 Css NA 0.09185 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034851 Css NA 0.4894 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034851 Css NA 0.05688 mg/L PBTK NA 50% Rat Human +DTXSID0034851 Css NA 0.2874 mg/L PBTK NA 95% Rat Human DTXSID0034855 Clint 234.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID0034855 Fup NA 0.0098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034855 Vd NA 2.478 L/kg 1compartment NA NA Human Human +DTXSID0034855 Fup 0.00824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034855 Vd NA 2.389 L/kg 1compartment NA NA Human Human DTXSID0034855 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0034855 TK.Half.Life NA 6.012 hours 1compartment NA NA Human Human -DTXSID0034855 Css NA 0.2444 mg/L 3compartmentss NA 50% Human Human -DTXSID0034855 Css NA 1.82 mg/L 3compartmentss NA 95% Human Human -DTXSID0034855 Css NA 0.1608 mg/L PBTK NA 50% Human Human -DTXSID0034855 Css NA 1.148 mg/L PBTK NA 95% Human Human +DTXSID0034855 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human +DTXSID0034855 Css NA 0.2552 mg/L 3compartmentss NA 50% Human Human +DTXSID0034855 Css NA 2.063 mg/L 3compartmentss NA 95% Human Human +DTXSID0034855 Css NA 0.1659 mg/L PBTK NA 50% Human Human +DTXSID0034855 Css NA 1.286 mg/L PBTK NA 95% Human Human DTXSID0034855 Clint 234.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID0034855 Fup NA 0.0098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034855 Vd NA 1.845 L/kg 1compartment NA NA Rat Human +DTXSID0034855 Fup 0.00824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034855 Vd NA 1.776 L/kg 1compartment NA NA Rat Human DTXSID0034855 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0034855 TK.Half.Life NA 1.651 hours 1compartment NA NA Rat Human -DTXSID0034855 Css NA 0.1373 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034855 Css NA 0.9023 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034855 Css NA 0.08568 mg/L PBTK NA 50% Rat Human -DTXSID0034855 Css NA 0.5243 mg/L PBTK NA 95% Rat Human +DTXSID0034855 TK.Half.Life NA 1.709 hours 1compartment NA NA Rat Human +DTXSID0034855 Css NA 0.03288 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034855 Css NA 0.2299 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034855 Css NA 0.02108 mg/L PBTK NA 50% Rat Human +DTXSID0034855 Css NA 0.1415 mg/L PBTK NA 95% Rat Human +DTXSID0034857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034857 Fup 0.00912 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034857 Vd NA 2.16 L/kg 1compartment NA NA Human Human +DTXSID0034857 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID0034857 TK.Half.Life NA 36.56 hours 1compartment NA NA Human Human +DTXSID0034857 Css NA 2.551 mg/L 3compartmentss NA 50% Human Human +DTXSID0034857 Css NA 20.63 mg/L 3compartmentss NA 95% Human Human +DTXSID0034857 Css NA 1.636 mg/L PBTK NA 50% Human Human +DTXSID0034857 Css NA 12.98 mg/L PBTK NA 95% Human Human +DTXSID0034857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034857 Fup 0.00912 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034857 Vd NA 1.602 L/kg 1compartment NA NA Rat Human +DTXSID0034857 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0034857 TK.Half.Life NA 10.85 hours 1compartment NA NA Rat Human +DTXSID0034857 Css NA 0.3348 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034857 Css NA 2.205 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034857 Css NA 0.2107 mg/L PBTK NA 50% Rat Human +DTXSID0034857 Css NA 1.358 mg/L PBTK NA 95% Rat Human DTXSID0034930 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0034930 Fup 0.4599 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0034930 Vd NA 1.337 L/kg 1compartment NA NA Human Human DTXSID0034930 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID0034930 TK.Half.Life NA 21.83 hours 1compartment NA NA Human Human -DTXSID0034930 Css NA 1.672 mg/L 3compartmentss NA 50% Human Human -DTXSID0034930 Css NA 7.646 mg/L 3compartmentss NA 95% Human Human -DTXSID0034930 Css NA 1.367 mg/L PBTK NA 50% Human Human -DTXSID0034930 Css NA 5.123 mg/L PBTK NA 95% Human Human +DTXSID0034930 Css NA 1.6 mg/L 3compartmentss NA 50% Human Human +DTXSID0034930 Css NA 7.586 mg/L 3compartmentss NA 95% Human Human +DTXSID0034930 Css NA 1.315 mg/L PBTK NA 50% Human Human +DTXSID0034930 Css NA 5.083 mg/L PBTK NA 95% Human Human DTXSID0034930 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0034930 Fup 0.4599 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0034930 Vd NA 1.142 L/kg 1compartment NA NA Rat Human DTXSID0034930 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0034930 TK.Half.Life NA 5.686 hours 1compartment NA NA Rat Human -DTXSID0034930 Css NA 0.4515 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034930 Css NA 1.791 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034930 Css NA 0.3572 mg/L PBTK NA 50% Rat Human -DTXSID0034930 Css NA 1.112 mg/L PBTK NA 95% Rat Human -DTXSID0034936 Clint NA 4.899 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034936 Fup NA 0.0609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0034936 Vd NA 0.2475 L/kg 1compartment NA NA Human Human +DTXSID0034930 Css NA 0.1027 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034930 Css NA 0.4067 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034930 Css NA 0.084 mg/L PBTK NA 50% Rat Human +DTXSID0034930 Css NA 0.2614 mg/L PBTK NA 95% Rat Human +DTXSID0034936 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034936 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0034936 Vd NA 0.3222 L/kg 1compartment NA NA Human Human DTXSID0034936 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0034936 TK.Half.Life NA 3.037 hours 1compartment NA NA Human Human -DTXSID0034936 Css NA 2.165 mg/L 3compartmentss NA 50% Human Human -DTXSID0034936 Css NA 14 mg/L 3compartmentss NA 95% Human Human -DTXSID0034936 Css NA 1.296 mg/L PBTK NA 50% Human Human -DTXSID0034936 Css NA 8.255 mg/L PBTK NA 95% Human Human -DTXSID0034936 Clint NA 4.899 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034936 Fup NA 0.0609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0034936 Vd NA 0.2462 L/kg 1compartment NA NA Rat Human +DTXSID0034936 TK.Half.Life NA 1.689 hours 1compartment NA NA Human Human +DTXSID0034936 Css NA 0.7015 mg/L 3compartmentss NA 50% Human Human +DTXSID0034936 Css NA 4.938 mg/L 3compartmentss NA 95% Human Human +DTXSID0034936 Css NA 0.4426 mg/L PBTK NA 50% Human Human +DTXSID0034936 Css NA 2.932 mg/L PBTK NA 95% Human Human +DTXSID0034936 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034936 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0034936 Vd NA 0.322 L/kg 1compartment NA NA Rat Human DTXSID0034936 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0034936 TK.Half.Life NA 1.851 hours 1compartment NA NA Rat Human -DTXSID0034936 Css NA 1.125 mg/L 3compartmentss NA 50% Rat Human -DTXSID0034936 Css NA 5.582 mg/L 3compartmentss NA 95% Rat Human -DTXSID0034936 Css NA 0.633 mg/L PBTK NA 50% Rat Human -DTXSID0034936 Css NA 3.079 mg/L PBTK NA 95% Rat Human -DTXSID0035748 Clint NA 0.04299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0035748 Fup NA 0.8545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0035748 Vd NA 1.017 L/kg 1compartment NA NA Human Human +DTXSID0034936 TK.Half.Life NA 1.02 hours 1compartment NA NA Rat Human +DTXSID0034936 Css NA 0.08752 mg/L 3compartmentss NA 50% Rat Human +DTXSID0034936 Css NA 0.4503 mg/L 3compartmentss NA 95% Rat Human +DTXSID0034936 Css NA 0.05349 mg/L PBTK NA 50% Rat Human +DTXSID0034936 Css NA 0.2604 mg/L PBTK NA 95% Rat Human +DTXSID0035748 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0035748 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0035748 Vd NA 0.5909 L/kg 1compartment NA NA Human Human DTXSID0035748 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0035748 TK.Half.Life NA 7.343 hours 1compartment NA NA Human Human -DTXSID0035748 Css NA 0.8312 mg/L 3compartmentss NA 50% Human Human -DTXSID0035748 Css NA 5.194 mg/L 3compartmentss NA 95% Human Human -DTXSID0035748 Css NA 0.7286 mg/L PBTK NA 50% Human Human -DTXSID0035748 Css NA 3.45 mg/L PBTK NA 95% Human Human -DTXSID0035748 Clint NA 0.04299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0035748 Fup NA 0.8545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0035748 Vd NA 0.9955 L/kg 1compartment NA NA Rat Human +DTXSID0035748 TK.Half.Life NA 8.104 hours 1compartment NA NA Human Human +DTXSID0035748 Css NA 1.489 mg/L 3compartmentss NA 50% Human Human +DTXSID0035748 Css NA 7.019 mg/L 3compartmentss NA 95% Human Human +DTXSID0035748 Css NA 1.127 mg/L PBTK NA 50% Human Human +DTXSID0035748 Css NA 4.478 mg/L PBTK NA 95% Human Human +DTXSID0035748 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0035748 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0035748 Vd NA 0.5989 L/kg 1compartment NA NA Rat Human DTXSID0035748 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0035748 TK.Half.Life NA 2.496 hours 1compartment NA NA Rat Human -DTXSID0035748 Css NA 0.2229 mg/L 3compartmentss NA 50% Rat Human -DTXSID0035748 Css NA 1.352 mg/L 3compartmentss NA 95% Rat Human -DTXSID0035748 Css NA 0.1905 mg/L PBTK NA 50% Rat Human -DTXSID0035748 Css NA 0.8288 mg/L PBTK NA 95% Rat Human -DTXSID0035790 Clint NA 12.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0035790 Fup NA 0.4748 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0035790 Vd NA 0.8201 L/kg 1compartment NA NA Human Human +DTXSID0035748 TK.Half.Life NA 2.794 hours 1compartment NA NA Rat Human +DTXSID0035748 Css NA 0.09398 mg/L 3compartmentss NA 50% Rat Human +DTXSID0035748 Css NA 0.4016 mg/L 3compartmentss NA 95% Rat Human +DTXSID0035748 Css NA 0.07036 mg/L PBTK NA 50% Rat Human +DTXSID0035748 Css NA 0.2462 mg/L PBTK NA 95% Rat Human +DTXSID0035790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0035790 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0035790 Vd NA 0.6662 L/kg 1compartment NA NA Human Human DTXSID0035790 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0035790 TK.Half.Life NA 1.039 hours 1compartment NA NA Human Human -DTXSID0035790 Css NA 0.07439 mg/L 3compartmentss NA 50% Human Human -DTXSID0035790 Css NA 0.5889 mg/L 3compartmentss NA 95% Human Human -DTXSID0035790 Css NA 0.05676 mg/L PBTK NA 50% Human Human -DTXSID0035790 Css NA 0.4026 mg/L PBTK NA 95% Human Human -DTXSID0035790 Clint NA 12.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0035790 Fup NA 0.4748 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0035790 Vd NA 0.7413 L/kg 1compartment NA NA Rat Human +DTXSID0035790 TK.Half.Life NA 0.8752 hours 1compartment NA NA Human Human +DTXSID0035790 Css NA 0.06745 mg/L 3compartmentss NA 50% Human Human +DTXSID0035790 Css NA 0.5237 mg/L 3compartmentss NA 95% Human Human +DTXSID0035790 Css NA 0.04753 mg/L PBTK NA 50% Human Human +DTXSID0035790 Css NA 0.3402 mg/L PBTK NA 95% Human Human +DTXSID0035790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0035790 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0035790 Vd NA 0.5959 L/kg 1compartment NA NA Rat Human DTXSID0035790 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0035790 TK.Half.Life NA 0.4902 hours 1compartment NA NA Rat Human -DTXSID0035790 Css NA 0.03828 mg/L 3compartmentss NA 50% Rat Human -DTXSID0035790 Css NA 0.2401 mg/L 3compartmentss NA 95% Rat Human -DTXSID0035790 Css NA 0.02834 mg/L PBTK NA 50% Rat Human -DTXSID0035790 Css NA 0.1538 mg/L PBTK NA 95% Rat Human -DTXSID0036508 Clint NA 14.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0036508 Fup NA 0.0731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0036508 Vd NA 1.935 L/kg 1compartment NA NA Human Human +DTXSID0035790 TK.Half.Life NA 0.4101 hours 1compartment NA NA Rat Human +DTXSID0035790 Css NA 0.008591 mg/L 3compartmentss NA 50% Rat Human +DTXSID0035790 Css NA 0.04933 mg/L 3compartmentss NA 95% Rat Human +DTXSID0035790 Css NA 0.006028 mg/L PBTK NA 50% Rat Human +DTXSID0035790 Css NA 0.03211 mg/L PBTK NA 95% Rat Human +DTXSID0036508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0036508 Fup 0.0713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0036508 Vd NA 2.39 L/kg 1compartment NA NA Human Human DTXSID0036508 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0036508 TK.Half.Life NA 11.06 hours 1compartment NA NA Human Human -DTXSID0036508 Css NA 0.7622 mg/L 3compartmentss NA 50% Human Human -DTXSID0036508 Css NA 5.17 mg/L 3compartmentss NA 95% Human Human -DTXSID0036508 Css NA 0.5032 mg/L PBTK NA 50% Human Human -DTXSID0036508 Css NA 3.253 mg/L PBTK NA 95% Human Human -DTXSID0036508 Clint NA 14.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0036508 Fup NA 0.0731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0036508 Vd NA 1.459 L/kg 1compartment NA NA Rat Human +DTXSID0036508 TK.Half.Life NA 12.35 hours 1compartment NA NA Human Human +DTXSID0036508 Css NA 0.5856 mg/L 3compartmentss NA 50% Human Human +DTXSID0036508 Css NA 3.919 mg/L 3compartmentss NA 95% Human Human +DTXSID0036508 Css NA 0.3979 mg/L PBTK NA 50% Human Human +DTXSID0036508 Css NA 2.566 mg/L PBTK NA 95% Human Human +DTXSID0036508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0036508 Fup 0.0713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0036508 Vd NA 1.797 L/kg 1compartment NA NA Rat Human DTXSID0036508 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0036508 TK.Half.Life NA 3.701 hours 1compartment NA NA Rat Human -DTXSID0036508 Css NA 0.4199 mg/L 3compartmentss NA 50% Rat Human -DTXSID0036508 Css NA 2.118 mg/L 3compartmentss NA 95% Rat Human -DTXSID0036508 Css NA 0.264 mg/L PBTK NA 50% Rat Human -DTXSID0036508 Css NA 1.287 mg/L PBTK NA 95% Rat Human -DTXSID0036760 Clint NA 28.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0036760 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0036760 Vd NA 0.3647 L/kg 1compartment NA NA Human Human -DTXSID0036760 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0036760 TK.Half.Life NA 0.6836 hours 1compartment NA NA Human Human -DTXSID0036760 Css NA 0.1661 mg/L 3compartmentss NA 50% Human Human -DTXSID0036760 Css NA 1.402 mg/L 3compartmentss NA 95% Human Human -DTXSID0036760 Css NA 0.1051 mg/L PBTK NA 50% Human Human -DTXSID0036760 Css NA 0.8577 mg/L PBTK NA 95% Human Human -DTXSID0036760 Clint NA 28.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0036760 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0036760 Vd NA 0.3524 L/kg 1compartment NA NA Rat Human -DTXSID0036760 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0036760 TK.Half.Life NA 0.3729 hours 1compartment NA NA Rat Human -DTXSID0036760 Css NA 0.09392 mg/L 3compartmentss NA 50% Rat Human -DTXSID0036760 Css NA 0.5857 mg/L 3compartmentss NA 95% Rat Human -DTXSID0036760 Css NA 0.05552 mg/L PBTK NA 50% Rat Human -DTXSID0036760 Css NA 0.3299 mg/L PBTK NA 95% Rat Human +DTXSID0036508 TK.Half.Life NA 3.393 hours 1compartment NA NA Rat Human +DTXSID0036508 Css NA 0.07647 mg/L 3compartmentss NA 50% Rat Human +DTXSID0036508 Css NA 0.408 mg/L 3compartmentss NA 95% Rat Human +DTXSID0036508 Css NA 0.05124 mg/L PBTK NA 50% Rat Human +DTXSID0036508 Css NA 0.2665 mg/L PBTK NA 95% Rat Human DTXSID0037023 Clint NA 0.08372 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0037023 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037023 Vd NA 1.938 L/kg 1compartment NA NA Human Human -DTXSID0037023 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0037023 TK.Half.Life NA 11.03 hours 1compartment NA NA Human Human -DTXSID0037023 Css NA 0.595 mg/L 3compartmentss NA 50% Human Human -DTXSID0037023 Css NA 4.393 mg/L 3compartmentss NA 95% Human Human -DTXSID0037023 Css NA 0.6021 mg/L PBTK NA 50% Human Human -DTXSID0037023 Css NA 3.08 mg/L PBTK NA 95% Human Human +DTXSID0037023 Vd NA 1.519 L/kg 1compartment NA NA Human Human +DTXSID0037023 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0037023 TK.Half.Life NA 8.63 hours 1compartment NA NA Human Human +DTXSID0037023 Css NA 0.3372 mg/L 3compartmentss NA 50% Human Human +DTXSID0037023 Css NA 2.352 mg/L 3compartmentss NA 95% Human Human +DTXSID0037023 Css NA 0.3252 mg/L PBTK NA 50% Human Human +DTXSID0037023 Css NA 1.642 mg/L PBTK NA 95% Human Human DTXSID0037023 Clint NA 0.08372 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0037023 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037023 Vd NA 1.977 L/kg 1compartment NA NA Rat Human +DTXSID0037023 Vd NA 1.566 L/kg 1compartment NA NA Rat Human DTXSID0037023 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0037023 TK.Half.Life NA 4.085 hours 1compartment NA NA Rat Human -DTXSID0037023 Css NA 0.1598 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037023 Css NA 1.154 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037023 Css NA 0.1621 mg/L PBTK NA 50% Rat Human -DTXSID0037023 Css NA 0.7416 mg/L PBTK NA 95% Rat Human -DTXSID0037231 Clint NA 28.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037231 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037231 Vd NA 0.2276 L/kg 1compartment NA NA Human Human -DTXSID0037231 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0037231 TK.Half.Life NA 3.995 hours 1compartment NA NA Human Human -DTXSID0037231 Css NA 3.157 mg/L 3compartmentss NA 50% Human Human -DTXSID0037231 Css NA 33.34 mg/L 3compartmentss NA 95% Human Human -DTXSID0037231 Css NA 1.871 mg/L PBTK NA 50% Human Human -DTXSID0037231 Css NA 19.24 mg/L PBTK NA 95% Human Human -DTXSID0037231 Clint NA 28.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037231 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037231 Vd NA 0.216 L/kg 1compartment NA NA Rat Human +DTXSID0037023 TK.Half.Life NA 3.233 hours 1compartment NA NA Rat Human +DTXSID0037023 Css NA 0.001828 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037023 Css NA 0.01512 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037023 Css NA 0.001757 mg/L PBTK NA 50% Rat Human +DTXSID0037023 Css NA 0.01019 mg/L PBTK NA 95% Rat Human +DTXSID0037231 Clint 5.94 NA uL/min/million hepatocytes NA Zanelli 2012 NA Human Human +DTXSID0037231 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037231 Vd NA 0.2736 L/kg 1compartment NA NA Human Human +DTXSID0037231 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0037231 TK.Half.Life NA 11.16 hours 1compartment NA NA Human Human +DTXSID0037231 Css NA 7.198 mg/L 3compartmentss NA 50% Human Human +DTXSID0037231 Css NA 64.36 mg/L 3compartmentss NA 95% Human Human +DTXSID0037231 Css NA 4.347 mg/L PBTK NA 50% Human Human +DTXSID0037231 Css NA 37.35 mg/L PBTK NA 95% Human Human +DTXSID0037231 Clint 5.94 NA uL/min/million hepatocytes NA Zanelli 2012 NA Rat Human +DTXSID0037231 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037231 Vd NA 0.2582 L/kg 1compartment NA NA Rat Human DTXSID0037231 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0037231 TK.Half.Life NA 2.551 hours 1compartment NA NA Rat Human -DTXSID0037231 Css NA 1.813 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037231 Css NA 14.84 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037231 Css NA 0.9984 mg/L PBTK NA 50% Rat Human -DTXSID0037231 Css NA 8.067 mg/L PBTK NA 95% Rat Human -DTXSID0037235 Clint NA 12.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037235 Fup NA 0.854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037235 Vd NA 0.84 L/kg 1compartment NA NA Human Human -DTXSID0037235 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0037235 TK.Half.Life NA 0.7401 hours 1compartment NA NA Human Human -DTXSID0037235 Css NA 0.04726 mg/L 3compartmentss NA 50% Human Human -DTXSID0037235 Css NA 0.424 mg/L 3compartmentss NA 95% Human Human -DTXSID0037235 Css NA 0.03788 mg/L PBTK NA 50% Human Human -DTXSID0037235 Css NA 0.2971 mg/L PBTK NA 95% Human Human -DTXSID0037235 Clint NA 12.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037235 Fup NA 0.854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037235 Vd NA 0.8569 L/kg 1compartment NA NA Rat Human -DTXSID0037235 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0037235 TK.Half.Life NA 0.3781 hours 1compartment NA NA Rat Human -DTXSID0037235 Css NA 0.02288 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037235 Css NA 0.1732 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037235 Css NA 0.01835 mg/L PBTK NA 50% Rat Human -DTXSID0037235 Css NA 0.1126 mg/L PBTK NA 95% Rat Human +DTXSID0037231 TK.Half.Life NA 6.684 hours 1compartment NA NA Rat Human +DTXSID0037231 Css NA 0.8998 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037231 Css NA 5.933 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037231 Css NA 0.5217 mg/L PBTK NA 50% Rat Human +DTXSID0037231 Css NA 3.338 mg/L PBTK NA 95% Rat Human DTXSID0037237 Clint 6.62 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0037237 Fup 0.021 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0037237 Vd NA 0.1891 L/kg 1compartment NA NA Human Human -DTXSID0037237 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0037237 TK.Half.Life NA 5.016 hours 1compartment NA NA Human Human -DTXSID0037237 Css NA 4.072 mg/L 3compartmentss NA 50% Human Human -DTXSID0037237 Css NA 35.31 mg/L 3compartmentss NA 95% Human Human -DTXSID0037237 Css NA 2.379 mg/L PBTK NA 50% Human Human -DTXSID0037237 Css NA 20.52 mg/L PBTK NA 95% Human Human +DTXSID0037237 Vd NA 1.114 L/kg 1compartment NA NA Human Human +DTXSID0037237 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0037237 TK.Half.Life NA 27.75 hours 1compartment NA NA Human Human +DTXSID0037237 Css NA 4.036 mg/L 3compartmentss NA 50% Human Human +DTXSID0037237 Css NA 33.65 mg/L 3compartmentss NA 95% Human Human +DTXSID0037237 Css NA 2.259 mg/L PBTK NA 50% Human Human +DTXSID0037237 Css NA 18.84 mg/L PBTK NA 95% Human Human DTXSID0037237 Clint 6.62 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID0037237 Fup 0.021 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0037237 Vd NA 0.1846 L/kg 1compartment NA NA Rat Human -DTXSID0037237 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0037237 TK.Half.Life NA 3.115 hours 1compartment NA NA Rat Human -DTXSID0037237 Css NA 2.652 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037237 Css NA 16.65 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037237 Css NA 1.432 mg/L PBTK NA 50% Rat Human -DTXSID0037237 Css NA 8.991 mg/L PBTK NA 95% Rat Human -DTXSID0037493 Clint NA 32.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037493 Fup NA 0.1714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037493 Vd NA 1.844 L/kg 1compartment NA NA Human Human +DTXSID0037237 Vd NA 0.833 L/kg 1compartment NA NA Rat Human +DTXSID0037237 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0037237 TK.Half.Life NA 11.62 hours 1compartment NA NA Rat Human +DTXSID0037237 Css NA 0.179 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037237 Css NA 1.602 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037237 Css NA 0.102 mg/L PBTK NA 50% Rat Human +DTXSID0037237 Css NA 0.9214 mg/L PBTK NA 95% Rat Human +DTXSID0037493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037493 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037493 Vd NA 1.967 L/kg 1compartment NA NA Human Human DTXSID0037493 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0037493 TK.Half.Life NA 3.134 hours 1compartment NA NA Human Human -DTXSID0037493 Css NA 0.1189 mg/L 3compartmentss NA 50% Human Human -DTXSID0037493 Css NA 0.7761 mg/L 3compartmentss NA 95% Human Human -DTXSID0037493 Css NA 0.08446 mg/L PBTK NA 50% Human Human -DTXSID0037493 Css NA 0.517 mg/L PBTK NA 95% Human Human -DTXSID0037493 Clint NA 32.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037493 Fup NA 0.1714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037493 Vd NA 1.422 L/kg 1compartment NA NA Rat Human +DTXSID0037493 TK.Half.Life NA 3.932 hours 1compartment NA NA Human Human +DTXSID0037493 Css NA 0.1492 mg/L 3compartmentss NA 50% Human Human +DTXSID0037493 Css NA 0.9789 mg/L 3compartmentss NA 95% Human Human +DTXSID0037493 Css NA 0.1082 mg/L PBTK NA 50% Human Human +DTXSID0037493 Css NA 0.6594 mg/L PBTK NA 95% Human Human +DTXSID0037493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037493 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037493 Vd NA 1.52 L/kg 1compartment NA NA Rat Human DTXSID0037493 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0037493 TK.Half.Life NA 1.11 hours 1compartment NA NA Rat Human -DTXSID0037493 Css NA 0.06379 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037493 Css NA 0.3292 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037493 Css NA 0.04368 mg/L PBTK NA 50% Rat Human -DTXSID0037493 Css NA 0.2154 mg/L PBTK NA 95% Rat Human +DTXSID0037493 TK.Half.Life NA 1.357 hours 1compartment NA NA Rat Human +DTXSID0037493 Css NA 0.01876 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037493 Css NA 0.09476 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037493 Css NA 0.01358 mg/L PBTK NA 50% Rat Human +DTXSID0037493 Css NA 0.06428 mg/L PBTK NA 95% Rat Human DTXSID0037495 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0037495 Fup 0.4588 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0037495 Vd NA 0.939 L/kg 1compartment NA NA Human Human DTXSID0037495 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID0037495 TK.Half.Life NA 13.87 hours 1compartment NA NA Human Human -DTXSID0037495 Css NA 1.562 mg/L 3compartmentss NA 50% Human Human -DTXSID0037495 Css NA 7.646 mg/L 3compartmentss NA 95% Human Human -DTXSID0037495 Css NA 1.246 mg/L PBTK NA 50% Human Human -DTXSID0037495 Css NA 4.983 mg/L PBTK NA 95% Human Human +DTXSID0037495 Css NA 1.507 mg/L 3compartmentss NA 50% Human Human +DTXSID0037495 Css NA 7.137 mg/L 3compartmentss NA 95% Human Human +DTXSID0037495 Css NA 1.203 mg/L PBTK NA 50% Human Human +DTXSID0037495 Css NA 4.736 mg/L PBTK NA 95% Human Human DTXSID0037495 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0037495 Fup 0.4588 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0037495 Vd NA 0.8588 L/kg 1compartment NA NA Rat Human DTXSID0037495 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0037495 TK.Half.Life NA 4.176 hours 1compartment NA NA Rat Human -DTXSID0037495 Css NA 0.4178 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037495 Css NA 1.805 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037495 Css NA 0.321 mg/L PBTK NA 50% Rat Human -DTXSID0037495 Css NA 1.095 mg/L PBTK NA 95% Rat Human -DTXSID0037522 Clint NA 124.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037522 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037522 Vd NA 2.815 L/kg 1compartment NA NA Human Human -DTXSID0037522 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0037522 TK.Half.Life NA 10.69 hours 1compartment NA NA Human Human -DTXSID0037522 Css NA 0.4168 mg/L 3compartmentss NA 50% Human Human -DTXSID0037522 Css NA 2.888 mg/L 3compartmentss NA 95% Human Human -DTXSID0037522 Css NA 0.2827 mg/L PBTK NA 50% Human Human -DTXSID0037522 Css NA 1.867 mg/L PBTK NA 95% Human Human -DTXSID0037522 Clint NA 124.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037522 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037522 Vd NA 2.104 L/kg 1compartment NA NA Rat Human -DTXSID0037522 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0037522 TK.Half.Life NA 2.327 hours 1compartment NA NA Rat Human -DTXSID0037522 Css NA 0.2356 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037522 Css NA 1.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037522 Css NA 0.1518 mg/L PBTK NA 50% Rat Human -DTXSID0037522 Css NA 0.8797 mg/L PBTK NA 95% Rat Human -DTXSID0037570 Clint NA 37.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037570 Fup NA 0.1505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037570 Vd NA 1.674 L/kg 1compartment NA NA Human Human +DTXSID0037495 Css NA 0.09621 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037495 Css NA 0.3982 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037495 Css NA 0.07624 mg/L PBTK NA 50% Rat Human +DTXSID0037495 Css NA 0.251 mg/L PBTK NA 95% Rat Human +DTXSID0037522 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037522 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037522 Vd NA 2.862 L/kg 1compartment NA NA Human Human +DTXSID0037522 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0037522 TK.Half.Life NA 49.44 hours 1compartment NA NA Human Human +DTXSID0037522 Css NA 2.214 mg/L 3compartmentss NA 50% Human Human +DTXSID0037522 Css NA 15.74 mg/L 3compartmentss NA 95% Human Human +DTXSID0037522 Css NA 1.494 mg/L PBTK NA 50% Human Human +DTXSID0037522 Css NA 10.4 mg/L PBTK NA 95% Human Human +DTXSID0037522 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037522 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037522 Vd NA 2.141 L/kg 1compartment NA NA Rat Human +DTXSID0037522 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID0037522 TK.Half.Life NA 9.122 hours 1compartment NA NA Rat Human +DTXSID0037522 Css NA 0.287 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037522 Css NA 1.687 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037522 Css NA 0.1927 mg/L PBTK NA 50% Rat Human +DTXSID0037522 Css NA 1.106 mg/L PBTK NA 95% Rat Human +DTXSID0037570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037570 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037570 Vd NA 1.549 L/kg 1compartment NA NA Human Human DTXSID0037570 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0037570 TK.Half.Life NA 2.74 hours 1compartment NA NA Human Human -DTXSID0037570 Css NA 0.1202 mg/L 3compartmentss NA 50% Human Human -DTXSID0037570 Css NA 0.9177 mg/L 3compartmentss NA 95% Human Human -DTXSID0037570 Css NA 0.0835 mg/L PBTK NA 50% Human Human -DTXSID0037570 Css NA 0.5933 mg/L PBTK NA 95% Human Human -DTXSID0037570 Clint NA 37.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037570 Fup NA 0.1505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037570 Vd NA 1.293 L/kg 1compartment NA NA Rat Human +DTXSID0037570 TK.Half.Life NA 3.796 hours 1compartment NA NA Human Human +DTXSID0037570 Css NA 0.24 mg/L 3compartmentss NA 50% Human Human +DTXSID0037570 Css NA 1.901 mg/L 3compartmentss NA 95% Human Human +DTXSID0037570 Css NA 0.1632 mg/L PBTK NA 50% Human Human +DTXSID0037570 Css NA 1.234 mg/L PBTK NA 95% Human Human +DTXSID0037570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037570 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037570 Vd NA 1.194 L/kg 1compartment NA NA Rat Human DTXSID0037570 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0037570 TK.Half.Life NA 1.004 hours 1compartment NA NA Rat Human -DTXSID0037570 Css NA 0.06789 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037570 Css NA 0.401 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037570 Css NA 0.04464 mg/L PBTK NA 50% Rat Human -DTXSID0037570 Css NA 0.2452 mg/L PBTK NA 95% Rat Human +DTXSID0037570 TK.Half.Life NA 1.456 hours 1compartment NA NA Rat Human +DTXSID0037570 Css NA 0.03063 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037570 Css NA 0.1827 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037570 Css NA 0.02049 mg/L PBTK NA 50% Rat Human +DTXSID0037570 Css NA 0.1142 mg/L PBTK NA 95% Rat Human DTXSID0037576 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0037576 Fup 0.205 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0037576 Vd NA 1.451 L/kg 1compartment NA NA Human Human DTXSID0037576 Days.Css NA 10 Days PBTK NA NA Human Human DTXSID0037576 TK.Half.Life NA 59.45 hours 1compartment NA NA Human Human -DTXSID0037576 Css NA 4.214 mg/L 3compartmentss NA 50% Human Human -DTXSID0037576 Css NA 12.6 mg/L 3compartmentss NA 95% Human Human -DTXSID0037576 Css NA 3.072 mg/L PBTK NA 50% Human Human -DTXSID0037576 Css NA 8.362 mg/L PBTK NA 95% Human Human +DTXSID0037576 Css NA 4.089 mg/L 3compartmentss NA 50% Human Human +DTXSID0037576 Css NA 11.92 mg/L 3compartmentss NA 95% Human Human +DTXSID0037576 Css NA 2.977 mg/L PBTK NA 50% Human Human +DTXSID0037576 Css NA 7.974 mg/L PBTK NA 95% Human Human DTXSID0037576 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0037576 Fup 0.205 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0037576 Vd NA 1.15 L/kg 1compartment NA NA Rat Human DTXSID0037576 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID0037576 TK.Half.Life NA 13.25 hours 1compartment NA NA Rat Human -DTXSID0037576 Css NA 1.163 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037576 Css NA 2.761 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037576 Css NA 0.8131 mg/L PBTK NA 50% Rat Human -DTXSID0037576 Css NA 1.702 mg/L PBTK NA 95% Rat Human -DTXSID0037730 Clint NA 15.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037730 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037730 Vd NA 0.2152 L/kg 1compartment NA NA Human Human +DTXSID0037576 Css NA 0.262 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037576 Css NA 0.62 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037576 Css NA 0.1898 mg/L PBTK NA 50% Rat Human +DTXSID0037576 Css NA 0.3955 mg/L PBTK NA 95% Rat Human +DTXSID0037653 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037653 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0037653 Vd NA 0.2879 L/kg 1compartment NA NA Human Human +DTXSID0037653 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0037653 TK.Half.Life NA 15.53 hours 1compartment NA NA Human Human +DTXSID0037653 Css NA 1.61 mg/L 3compartmentss NA 50% Human Human +DTXSID0037653 Css NA 7.496 mg/L 3compartmentss NA 95% Human Human +DTXSID0037653 Css NA 2.738 mg/L PBTK NA 50% Human Human +DTXSID0037653 Css NA 12.74 mg/L PBTK NA 95% Human Human +DTXSID0037653 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037653 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0037653 Vd NA 0.2878 L/kg 1compartment NA NA Rat Human +DTXSID0037653 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0037653 TK.Half.Life NA 5.287 hours 1compartment NA NA Rat Human +DTXSID0037653 Css NA 0.008354 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037653 Css NA 0.03835 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037653 Css NA 0.01424 mg/L PBTK NA 50% Rat Human +DTXSID0037653 Css NA 0.06539 mg/L PBTK NA 95% Rat Human +DTXSID0037730 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037730 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037730 Vd NA 0.3813 L/kg 1compartment NA NA Human Human DTXSID0037730 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0037730 TK.Half.Life NA 2.719 hours 1compartment NA NA Human Human -DTXSID0037730 Css NA 2.24 mg/L 3compartmentss NA 50% Human Human -DTXSID0037730 Css NA 21.62 mg/L 3compartmentss NA 95% Human Human -DTXSID0037730 Css NA 1.333 mg/L PBTK NA 50% Human Human -DTXSID0037730 Css NA 12.5 mg/L PBTK NA 95% Human Human -DTXSID0037730 Clint NA 15.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037730 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037730 Vd NA 0.2114 L/kg 1compartment NA NA Rat Human +DTXSID0037730 TK.Half.Life NA 2.366 hours 1compartment NA NA Human Human +DTXSID0037730 Css NA 0.4696 mg/L 3compartmentss NA 50% Human Human +DTXSID0037730 Css NA 3.542 mg/L 3compartmentss NA 95% Human Human +DTXSID0037730 Css NA 0.3012 mg/L PBTK NA 50% Human Human +DTXSID0037730 Css NA 2.146 mg/L PBTK NA 95% Human Human +DTXSID0037730 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037730 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037730 Vd NA 0.3767 L/kg 1compartment NA NA Rat Human DTXSID0037730 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0037730 TK.Half.Life NA 1.753 hours 1compartment NA NA Rat Human -DTXSID0037730 Css NA 1.267 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037730 Css NA 9.116 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037730 Css NA 0.699 mg/L PBTK NA 50% Rat Human -DTXSID0037730 Css NA 4.956 mg/L PBTK NA 95% Rat Human -DTXSID0037734 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037734 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0037734 Vd NA 3.493 L/kg 1compartment NA NA Human Human -DTXSID0037734 Days.Css NA 58 Days PBTK NA NA Human Human -DTXSID0037734 TK.Half.Life NA 270.5 hours 1compartment NA NA Human Human -DTXSID0037734 Css NA 11.07 mg/L 3compartmentss NA 50% Human Human -DTXSID0037734 Css NA 112 mg/L 3compartmentss NA 95% Human Human -DTXSID0037734 Css NA 8.46 mg/L PBTK NA 50% Human Human -DTXSID0037734 Css NA 71.57 mg/L PBTK NA 95% Human Human -DTXSID0037734 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037734 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0037734 Vd NA 2.66 L/kg 1compartment NA NA Rat Human -DTXSID0037734 Days.Css NA 29 Days PBTK NA NA Rat Human -DTXSID0037734 TK.Half.Life NA 126.5 hours 1compartment NA NA Rat Human -DTXSID0037734 Css NA 5.854 mg/L 3compartmentss NA 50% Rat Human -DTXSID0037734 Css NA 47.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID0037734 Css NA 4.235 mg/L PBTK NA 50% Rat Human -DTXSID0037734 Css NA 27.72 mg/L PBTK NA 95% Rat Human -DTXSID0038700 Clint NA 24.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038700 Fup NA 0.5337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038700 Vd NA 1.314 L/kg 1compartment NA NA Human Human +DTXSID0037730 TK.Half.Life NA 1.425 hours 1compartment NA NA Rat Human +DTXSID0037730 Css NA 0.004832 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037730 Css NA 0.03011 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037730 Css NA 0.002914 mg/L PBTK NA 50% Rat Human +DTXSID0037730 Css NA 0.01727 mg/L PBTK NA 95% Rat Human +DTXSID0037734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037734 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0037734 Vd NA 0.9982 L/kg 1compartment NA NA Human Human +DTXSID0037734 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0037734 TK.Half.Life NA 9.455 hours 1compartment NA NA Human Human +DTXSID0037734 Css NA 1.444 mg/L 3compartmentss NA 50% Human Human +DTXSID0037734 Css NA 14.6 mg/L 3compartmentss NA 95% Human Human +DTXSID0037734 Css NA 0.953 mg/L PBTK NA 50% Human Human +DTXSID0037734 Css NA 8.881 mg/L PBTK NA 95% Human Human +DTXSID0037734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037734 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0037734 Vd NA 0.8031 L/kg 1compartment NA NA Rat Human +DTXSID0037734 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0037734 TK.Half.Life NA 4.652 hours 1compartment NA NA Rat Human +DTXSID0037734 Css NA 0.1852 mg/L 3compartmentss NA 50% Rat Human +DTXSID0037734 Css NA 1.538 mg/L 3compartmentss NA 95% Rat Human +DTXSID0037734 Css NA 0.1191 mg/L PBTK NA 50% Rat Human +DTXSID0037734 Css NA 0.904 mg/L PBTK NA 95% Rat Human +DTXSID0038338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038338 Fup 0.00117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038338 Vd NA 6.391 L/kg 1compartment NA NA Human Human +DTXSID0038338 Days.Css NA 41 Days PBTK NA NA Human Human +DTXSID0038338 TK.Half.Life NA 212 hours 1compartment NA NA Human Human +DTXSID0038338 Css NA 2.923 mg/L 3compartmentss NA 50% Human Human +DTXSID0038338 Css NA 16.84 mg/L 3compartmentss NA 95% Human Human +DTXSID0038338 Css NA 2.644 mg/L PBTK NA 50% Human Human +DTXSID0038338 Css NA 15.09 mg/L PBTK NA 95% Human Human +DTXSID0038338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038338 Fup 0.00117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038338 Vd NA 4.932 L/kg 1compartment NA NA Rat Human +DTXSID0038338 Days.Css NA 24 Days PBTK NA NA Rat Human +DTXSID0038338 TK.Half.Life NA 37.19 hours 1compartment NA NA Rat Human +DTXSID0038338 Css NA 0.3769 mg/L 3compartmentss NA 50% Rat Human +DTXSID0038338 Css NA 1.767 mg/L 3compartmentss NA 95% Rat Human +DTXSID0038338 Css NA 0.3426 mg/L PBTK NA 50% Rat Human +DTXSID0038338 Css NA 1.63 mg/L PBTK NA 95% Rat Human +DTXSID0038700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038700 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038700 Vd NA 1.144 L/kg 1compartment NA NA Human Human DTXSID0038700 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0038700 TK.Half.Life NA 1.21 hours 1compartment NA NA Human Human -DTXSID0038700 Css NA 0.03559 mg/L 3compartmentss NA 50% Human Human -DTXSID0038700 Css NA 0.3288 mg/L 3compartmentss NA 95% Human Human -DTXSID0038700 Css NA 0.02996 mg/L PBTK NA 50% Human Human -DTXSID0038700 Css NA 0.2338 mg/L PBTK NA 95% Human Human -DTXSID0038700 Clint NA 24.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038700 Fup NA 0.5337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038700 Vd NA 1.145 L/kg 1compartment NA NA Rat Human +DTXSID0038700 TK.Half.Life NA 1.552 hours 1compartment NA NA Human Human +DTXSID0038700 Css NA 0.07362 mg/L 3compartmentss NA 50% Human Human +DTXSID0038700 Css NA 0.5723 mg/L 3compartmentss NA 95% Human Human +DTXSID0038700 Css NA 0.05472 mg/L PBTK NA 50% Human Human +DTXSID0038700 Css NA 0.3848 mg/L PBTK NA 95% Human Human +DTXSID0038700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038700 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038700 Vd NA 0.9569 L/kg 1compartment NA NA Rat Human DTXSID0038700 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0038700 TK.Half.Life NA 0.5112 hours 1compartment NA NA Rat Human -DTXSID0038700 Css NA 0.01877 mg/L 3compartmentss NA 50% Rat Human -DTXSID0038700 Css NA 0.1425 mg/L 3compartmentss NA 95% Rat Human -DTXSID0038700 Css NA 0.01531 mg/L PBTK NA 50% Rat Human -DTXSID0038700 Css NA 0.0968 mg/L PBTK NA 95% Rat Human -DTXSID0038756 Clint NA 3.287 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038756 Fup NA 0.7756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038756 Vd NA 1.614 L/kg 1compartment NA NA Human Human -DTXSID0038756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0038756 TK.Half.Life NA 3.066 hours 1compartment NA NA Human Human -DTXSID0038756 Css NA 0.1604 mg/L 3compartmentss NA 50% Human Human -DTXSID0038756 Css NA 1.277 mg/L 3compartmentss NA 95% Human Human -DTXSID0038756 Css NA 0.1464 mg/L PBTK NA 50% Human Human -DTXSID0038756 Css NA 0.8884 mg/L PBTK NA 95% Human Human -DTXSID0038756 Clint NA 3.287 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038756 Fup NA 0.7756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038756 Vd NA 1.412 L/kg 1compartment NA NA Rat Human -DTXSID0038756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0038756 TK.Half.Life NA 1.304 hours 1compartment NA NA Rat Human -DTXSID0038756 Css NA 0.07222 mg/L 3compartmentss NA 50% Rat Human -DTXSID0038756 Css NA 0.5217 mg/L 3compartmentss NA 95% Rat Human -DTXSID0038756 Css NA 0.06512 mg/L PBTK NA 50% Rat Human -DTXSID0038756 Css NA 0.3319 mg/L PBTK NA 95% Rat Human -DTXSID0038831 Clint NA 0.09632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038831 Fup NA 0.5918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038831 Vd NA 0.4179 L/kg 1compartment NA NA Human Human +DTXSID0038700 TK.Half.Life NA 0.6658 hours 1compartment NA NA Rat Human +DTXSID0038700 Css NA 0.009424 mg/L 3compartmentss NA 50% Rat Human +DTXSID0038700 Css NA 0.05092 mg/L 3compartmentss NA 95% Rat Human +DTXSID0038700 Css NA 0.006932 mg/L PBTK NA 50% Rat Human +DTXSID0038700 Css NA 0.03453 mg/L PBTK NA 95% Rat Human +DTXSID0038831 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038831 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038831 Vd NA 0.75 L/kg 1compartment NA NA Human Human DTXSID0038831 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0038831 TK.Half.Life NA 3.945 hours 1compartment NA NA Human Human -DTXSID0038831 Css NA 1.172 mg/L 3compartmentss NA 50% Human Human -DTXSID0038831 Css NA 7.255 mg/L 3compartmentss NA 95% Human Human -DTXSID0038831 Css NA 0.8402 mg/L PBTK NA 50% Human Human -DTXSID0038831 Css NA 4.453 mg/L PBTK NA 95% Human Human -DTXSID0038831 Clint NA 0.09632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038831 Fup NA 0.5918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038831 Vd NA 0.4326 L/kg 1compartment NA NA Rat Human +DTXSID0038831 TK.Half.Life NA 6.022 hours 1compartment NA NA Human Human +DTXSID0038831 Css NA 0.955 mg/L 3compartmentss NA 50% Human Human +DTXSID0038831 Css NA 5.782 mg/L 3compartmentss NA 95% Human Human +DTXSID0038831 Css NA 0.7872 mg/L PBTK NA 50% Human Human +DTXSID0038831 Css NA 3.821 mg/L PBTK NA 95% Human Human +DTXSID0038831 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038831 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038831 Vd NA 0.773 L/kg 1compartment NA NA Rat Human DTXSID0038831 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0038831 TK.Half.Life NA 1.496 hours 1compartment NA NA Rat Human -DTXSID0038831 Css NA 0.3426 mg/L 3compartmentss NA 50% Rat Human -DTXSID0038831 Css NA 2.065 mg/L 3compartmentss NA 95% Rat Human -DTXSID0038831 Css NA 0.2329 mg/L PBTK NA 50% Rat Human -DTXSID0038831 Css NA 1.173 mg/L PBTK NA 95% Rat Human -DTXSID0038839 Clint NA 4.484 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038839 Fup NA 0.6228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038839 Vd NA 0.8559 L/kg 1compartment NA NA Human Human +DTXSID0038831 TK.Half.Life NA 2.113 hours 1compartment NA NA Rat Human +DTXSID0038831 Css NA 0.05636 mg/L 3compartmentss NA 50% Rat Human +DTXSID0038831 Css NA 0.3329 mg/L 3compartmentss NA 95% Rat Human +DTXSID0038831 Css NA 0.04686 mg/L PBTK NA 50% Rat Human +DTXSID0038831 Css NA 0.2068 mg/L PBTK NA 95% Rat Human +DTXSID0038839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038839 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038839 Vd NA 0.6663 L/kg 1compartment NA NA Human Human DTXSID0038839 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0038839 TK.Half.Life NA 1.486 hours 1compartment NA NA Human Human -DTXSID0038839 Css NA 0.1487 mg/L 3compartmentss NA 50% Human Human -DTXSID0038839 Css NA 1.284 mg/L 3compartmentss NA 95% Human Human -DTXSID0038839 Css NA 0.1218 mg/L PBTK NA 50% Human Human -DTXSID0038839 Css NA 0.8593 mg/L PBTK NA 95% Human Human -DTXSID0038839 Clint NA 4.484 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038839 Fup NA 0.6228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038839 Vd NA 0.8324 L/kg 1compartment NA NA Rat Human +DTXSID0038839 TK.Half.Life NA 1.346 hours 1compartment NA NA Human Human +DTXSID0038839 Css NA 0.1762 mg/L 3compartmentss NA 50% Human Human +DTXSID0038839 Css NA 1.452 mg/L 3compartmentss NA 95% Human Human +DTXSID0038839 Css NA 0.1152 mg/L PBTK NA 50% Human Human +DTXSID0038839 Css NA 0.9003 mg/L PBTK NA 95% Human Human +DTXSID0038839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038839 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038839 Vd NA 0.5701 L/kg 1compartment NA NA Rat Human DTXSID0038839 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0038839 TK.Half.Life NA 0.7792 hours 1compartment NA NA Rat Human -DTXSID0038839 Css NA 0.06976 mg/L 3compartmentss NA 50% Rat Human -DTXSID0038839 Css NA 0.5226 mg/L 3compartmentss NA 95% Rat Human -DTXSID0038839 Css NA 0.05568 mg/L PBTK NA 50% Rat Human -DTXSID0038839 Css NA 0.3115 mg/L PBTK NA 95% Rat Human -DTXSID0038881 Clint NA 137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038881 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0038881 Vd NA 0.1943 L/kg 1compartment NA NA Human Human +DTXSID0038839 TK.Half.Life NA 0.649 hours 1compartment NA NA Rat Human +DTXSID0038839 Css NA 0.0232 mg/L 3compartmentss NA 50% Rat Human +DTXSID0038839 Css NA 0.1419 mg/L 3compartmentss NA 95% Rat Human +DTXSID0038839 Css NA 0.0148 mg/L PBTK NA 50% Rat Human +DTXSID0038839 Css NA 0.08674 mg/L PBTK NA 95% Rat Human +DTXSID0038881 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038881 Fup 0.0793 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0038881 Vd NA 0.2388 L/kg 1compartment NA NA Human Human DTXSID0038881 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0038881 TK.Half.Life NA 1.136 hours 1compartment NA NA Human Human -DTXSID0038881 Css NA 0.9637 mg/L 3compartmentss NA 50% Human Human -DTXSID0038881 Css NA 9.519 mg/L 3compartmentss NA 95% Human Human -DTXSID0038881 Css NA 0.5662 mg/L PBTK NA 50% Human Human -DTXSID0038881 Css NA 5.526 mg/L PBTK NA 95% Human Human -DTXSID0038881 Clint NA 137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038881 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0038881 Vd NA 0.1894 L/kg 1compartment NA NA Rat Human +DTXSID0038881 TK.Half.Life NA 0.7386 hours 1compartment NA NA Human Human +DTXSID0038881 Css NA 0.3788 mg/L 3compartmentss NA 50% Human Human +DTXSID0038881 Css NA 3.067 mg/L 3compartmentss NA 95% Human Human +DTXSID0038881 Css NA 0.2284 mg/L PBTK NA 50% Human Human +DTXSID0038881 Css NA 1.8 mg/L PBTK NA 95% Human Human +DTXSID0038881 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038881 Fup 0.0793 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0038881 Vd NA 0.2428 L/kg 1compartment NA NA Rat Human DTXSID0038881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0038881 TK.Half.Life NA 0.7257 hours 1compartment NA NA Rat Human -DTXSID0038881 Css NA 0.5494 mg/L 3compartmentss NA 50% Rat Human -DTXSID0038881 Css NA 5.027 mg/L 3compartmentss NA 95% Rat Human -DTXSID0038881 Css NA 0.2997 mg/L PBTK NA 50% Rat Human -DTXSID0038881 Css NA 2.739 mg/L PBTK NA 95% Rat Human +DTXSID0038881 TK.Half.Life NA 0.4548 hours 1compartment NA NA Rat Human +DTXSID0038881 Css NA 0.05024 mg/L 3compartmentss NA 50% Rat Human +DTXSID0038881 Css NA 0.2999 mg/L 3compartmentss NA 95% Rat Human +DTXSID0038881 Css NA 0.02927 mg/L PBTK NA 50% Rat Human +DTXSID0038881 Css NA 0.1707 mg/L PBTK NA 95% Rat Human DTXSID0038887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0038887 Fup 0.151 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0038887 Vd NA 1.504 L/kg 1compartment NA NA Human Human -DTXSID0038887 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID0038887 TK.Half.Life NA 87.45 hours 1compartment NA NA Human Human -DTXSID0038887 Css NA 6.3 mg/L 3compartmentss NA 50% Human Human -DTXSID0038887 Css NA 20.22 mg/L 3compartmentss NA 95% Human Human -DTXSID0038887 Css NA 4.438 mg/L PBTK NA 50% Human Human -DTXSID0038887 Css NA 13 mg/L PBTK NA 95% Human Human +DTXSID0038887 Vd NA 1.72 L/kg 1compartment NA NA Human Human +DTXSID0038887 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID0038887 TK.Half.Life NA 111.6 hours 1compartment NA NA Human Human +DTXSID0038887 Css NA 4.488 mg/L 3compartmentss NA 50% Human Human +DTXSID0038887 Css NA 14.81 mg/L 3compartmentss NA 95% Human Human +DTXSID0038887 Css NA 3.18 mg/L PBTK NA 50% Human Human +DTXSID0038887 Css NA 9.639 mg/L PBTK NA 95% Human Human DTXSID0038887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0038887 Fup 0.151 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0038887 Vd NA 1.169 L/kg 1compartment NA NA Rat Human -DTXSID0038887 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0038887 TK.Half.Life NA 18.52 hours 1compartment NA NA Rat Human -DTXSID0038887 Css NA 1.729 mg/L 3compartmentss NA 50% Rat Human -DTXSID0038887 Css NA 4.398 mg/L 3compartmentss NA 95% Rat Human -DTXSID0038887 Css NA 1.163 mg/L PBTK NA 50% Rat Human -DTXSID0038887 Css NA 2.632 mg/L PBTK NA 95% Rat Human +DTXSID0038887 Vd NA 1.325 L/kg 1compartment NA NA Rat Human +DTXSID0038887 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0038887 TK.Half.Life NA 21.72 hours 1compartment NA NA Rat Human +DTXSID0038887 Css NA 0.02831 mg/L 3compartmentss NA 50% Rat Human +DTXSID0038887 Css NA 0.124 mg/L 3compartmentss NA 95% Rat Human +DTXSID0038887 Css NA 0.01918 mg/L PBTK NA 50% Rat Human +DTXSID0038887 Css NA 0.08014 mg/L PBTK NA 95% Rat Human +DTXSID00391122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00391122 Fup 0.0497 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00391122 Vd NA 0.3825 L/kg 1compartment NA NA Human Human +DTXSID00391122 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00391122 TK.Half.Life NA 1.656 hours 1compartment NA NA Human Human +DTXSID00391122 Css NA 0.5962 mg/L 3compartmentss NA 50% Human Human +DTXSID00391122 Css NA 5.16 mg/L 3compartmentss NA 95% Human Human +DTXSID00391122 Css NA 0.3766 mg/L PBTK NA 50% Human Human +DTXSID00391122 Css NA 3.13 mg/L PBTK NA 95% Human Human +DTXSID00391122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00391122 Fup 0.0497 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00391122 Vd NA 0.3674 L/kg 1compartment NA NA Rat Human +DTXSID00391122 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00391122 TK.Half.Life NA 1.002 hours 1compartment NA NA Rat Human +DTXSID00391122 Css NA 0.07854 mg/L 3compartmentss NA 50% Rat Human +DTXSID00391122 Css NA 0.5202 mg/L 3compartmentss NA 95% Rat Human +DTXSID00391122 Css NA 0.04806 mg/L PBTK NA 50% Rat Human +DTXSID00391122 Css NA 0.3063 mg/L PBTK NA 95% Rat Human DTXSID0039223 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0039223 Fup 0.4809 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID0039223 Vd NA 0.5812 L/kg 1compartment NA NA Human Human DTXSID0039223 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0039223 TK.Half.Life NA 7.899 hours 1compartment NA NA Human Human -DTXSID0039223 Css NA 1.547 mg/L 3compartmentss NA 50% Human Human -DTXSID0039223 Css NA 7.562 mg/L 3compartmentss NA 95% Human Human -DTXSID0039223 Css NA 1.146 mg/L PBTK NA 50% Human Human -DTXSID0039223 Css NA 4.794 mg/L PBTK NA 95% Human Human +DTXSID0039223 Css NA 1.498 mg/L 3compartmentss NA 50% Human Human +DTXSID0039223 Css NA 7.122 mg/L 3compartmentss NA 95% Human Human +DTXSID0039223 Css NA 1.112 mg/L PBTK NA 50% Human Human +DTXSID0039223 Css NA 4.517 mg/L PBTK NA 95% Human Human DTXSID0039223 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0039223 Fup 0.4809 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID0039223 Vd NA 0.5603 L/kg 1compartment NA NA Rat Human DTXSID0039223 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0039223 TK.Half.Life NA 2.576 hours 1compartment NA NA Rat Human -DTXSID0039223 Css NA 0.4213 mg/L 3compartmentss NA 50% Rat Human -DTXSID0039223 Css NA 1.806 mg/L 3compartmentss NA 95% Rat Human -DTXSID0039223 Css NA 0.2985 mg/L PBTK NA 50% Rat Human -DTXSID0039223 Css NA 1.061 mg/L PBTK NA 95% Rat Human -DTXSID0039227 Clint NA 4.729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0039227 Fup NA 0.0672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0039227 Vd NA 1.482 L/kg 1compartment NA NA Human Human -DTXSID0039227 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0039227 TK.Half.Life NA 19.59 hours 1compartment NA NA Human Human -DTXSID0039227 Css NA 1.921 mg/L 3compartmentss NA 50% Human Human -DTXSID0039227 Css NA 11.12 mg/L 3compartmentss NA 95% Human Human -DTXSID0039227 Css NA 1.245 mg/L PBTK NA 50% Human Human -DTXSID0039227 Css NA 6.768 mg/L PBTK NA 95% Human Human -DTXSID0039227 Clint NA 4.729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0039227 Fup NA 0.0672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0039227 Vd NA 1.122 L/kg 1compartment NA NA Rat Human +DTXSID0039223 Css NA 0.09543 mg/L 3compartmentss NA 50% Rat Human +DTXSID0039223 Css NA 0.4145 mg/L 3compartmentss NA 95% Rat Human +DTXSID0039223 Css NA 0.07001 mg/L PBTK NA 50% Rat Human +DTXSID0039223 Css NA 0.252 mg/L PBTK NA 95% Rat Human +DTXSID0039227 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0039227 Fup 0.0556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0039227 Vd NA 1.839 L/kg 1compartment NA NA Human Human +DTXSID0039227 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0039227 TK.Half.Life NA 8.749 hours 1compartment NA NA Human Human +DTXSID0039227 Css NA 0.61 mg/L 3compartmentss NA 50% Human Human +DTXSID0039227 Css NA 4.53 mg/L 3compartmentss NA 95% Human Human +DTXSID0039227 Css NA 0.3972 mg/L PBTK NA 50% Human Human +DTXSID0039227 Css NA 2.83 mg/L PBTK NA 95% Human Human +DTXSID0039227 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0039227 Fup 0.0556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0039227 Vd NA 1.381 L/kg 1compartment NA NA Rat Human DTXSID0039227 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0039227 TK.Half.Life NA 7.337 hours 1compartment NA NA Rat Human -DTXSID0039227 Css NA 0.9956 mg/L 3compartmentss NA 50% Rat Human -DTXSID0039227 Css NA 4.165 mg/L 3compartmentss NA 95% Rat Human -DTXSID0039227 Css NA 0.6112 mg/L PBTK NA 50% Rat Human -DTXSID0039227 Css NA 2.403 mg/L PBTK NA 95% Rat Human +DTXSID0039227 TK.Half.Life NA 3.035 hours 1compartment NA NA Rat Human +DTXSID0039227 Css NA 0.07847 mg/L 3compartmentss NA 50% Rat Human +DTXSID0039227 Css NA 0.4636 mg/L 3compartmentss NA 95% Rat Human +DTXSID0039227 Css NA 0.0501 mg/L PBTK NA 50% Rat Human +DTXSID0039227 Css NA 0.2844 mg/L PBTK NA 95% Rat Human DTXSID0039229 Clint NA 0.007305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0039229 Fup NA 0.3914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0039229 Vd NA 0.4229 L/kg 1compartment NA NA Human Human DTXSID0039229 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0039229 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human -DTXSID0039229 Css NA 1.879 mg/L 3compartmentss NA 50% Human Human -DTXSID0039229 Css NA 8.257 mg/L 3compartmentss NA 95% Human Human -DTXSID0039229 Css NA 1.346 mg/L PBTK NA 50% Human Human -DTXSID0039229 Css NA 5.212 mg/L PBTK NA 95% Human Human +DTXSID0039229 Css NA 1.586 mg/L 3compartmentss NA 50% Human Human +DTXSID0039229 Css NA 7.135 mg/L 3compartmentss NA 95% Human Human +DTXSID0039229 Css NA 1.13 mg/L PBTK NA 50% Human Human +DTXSID0039229 Css NA 4.453 mg/L PBTK NA 95% Human Human DTXSID0039229 Clint NA 0.007305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0039229 Fup NA 0.3914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0039229 Vd NA 0.4323 L/kg 1compartment NA NA Rat Human DTXSID0039229 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0039229 TK.Half.Life NA 2.42 hours 1compartment NA NA Rat Human -DTXSID0039229 Css NA 0.5266 mg/L 3compartmentss NA 50% Rat Human -DTXSID0039229 Css NA 1.908 mg/L 3compartmentss NA 95% Rat Human -DTXSID0039229 Css NA 0.3558 mg/L PBTK NA 50% Rat Human -DTXSID0039229 Css NA 1.113 mg/L PBTK NA 95% Rat Human -DTXSID0040127 Clint NA 0.2699 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040127 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040127 Vd NA 3.437 L/kg 1compartment NA NA Human Human -DTXSID0040127 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0040127 TK.Half.Life NA 15.48 hours 1compartment NA NA Human Human -DTXSID0040127 Css NA 0.3804 mg/L 3compartmentss NA 50% Human Human -DTXSID0040127 Css NA 3.318 mg/L 3compartmentss NA 95% Human Human -DTXSID0040127 Css NA 0.4756 mg/L PBTK NA 50% Human Human -DTXSID0040127 Css NA 2.448 mg/L PBTK NA 95% Human Human -DTXSID0040127 Clint NA 0.2699 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040127 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040127 Vd NA 3.508 L/kg 1compartment NA NA Rat Human +DTXSID0039229 Css NA 0.02928 mg/L 3compartmentss NA 50% Rat Human +DTXSID0039229 Css NA 0.1852 mg/L 3compartmentss NA 95% Rat Human +DTXSID0039229 Css NA 0.02005 mg/L PBTK NA 50% Rat Human +DTXSID0039229 Css NA 0.115 mg/L PBTK NA 95% Rat Human +DTXSID0040123 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040123 Fup 0.0996 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040123 Vd NA 1.672 L/kg 1compartment NA NA Human Human +DTXSID0040123 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0040123 TK.Half.Life NA 4.983 hours 1compartment NA NA Human Human +DTXSID0040123 Css NA 0.326 mg/L 3compartmentss NA 50% Human Human +DTXSID0040123 Css NA 2.426 mg/L 3compartmentss NA 95% Human Human +DTXSID0040123 Css NA 0.2158 mg/L PBTK NA 50% Human Human +DTXSID0040123 Css NA 1.537 mg/L PBTK NA 95% Human Human +DTXSID0040123 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040123 Fup 0.0996 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040123 Vd NA 1.272 L/kg 1compartment NA NA Rat Human +DTXSID0040123 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0040123 TK.Half.Life NA 1.838 hours 1compartment NA NA Rat Human +DTXSID0040123 Css NA 0.04188 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040123 Css NA 0.2454 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040123 Css NA 0.02734 mg/L PBTK NA 50% Rat Human +DTXSID0040123 Css NA 0.1531 mg/L PBTK NA 95% Rat Human +DTXSID0040127 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040127 Fup 0.775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040127 Vd NA 2.476 L/kg 1compartment NA NA Human Human +DTXSID0040127 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0040127 TK.Half.Life NA 20.68 hours 1compartment NA NA Human Human +DTXSID0040127 Css NA 0.6532 mg/L 3compartmentss NA 50% Human Human +DTXSID0040127 Css NA 4.674 mg/L 3compartmentss NA 95% Human Human +DTXSID0040127 Css NA 0.7123 mg/L PBTK NA 50% Human Human +DTXSID0040127 Css NA 3.398 mg/L PBTK NA 95% Human Human +DTXSID0040127 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040127 Fup 0.775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040127 Vd NA 2.515 L/kg 1compartment NA NA Rat Human DTXSID0040127 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040127 TK.Half.Life NA 6.365 hours 1compartment NA NA Rat Human -DTXSID0040127 Css NA 0.1119 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040127 Css NA 0.9077 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040127 Css NA 0.1422 mg/L PBTK NA 50% Rat Human -DTXSID0040127 Css NA 0.6379 mg/L PBTK NA 95% Rat Human -DTXSID0040129 Clint NA 75.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040129 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040129 Vd NA 0.479 L/kg 1compartment NA NA Human Human +DTXSID0040127 TK.Half.Life NA 7.156 hours 1compartment NA NA Rat Human +DTXSID0040127 Css NA 0.01205 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040127 Css NA 0.1081 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040127 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID0040127 Css NA 0.08039 mg/L PBTK NA 95% Rat Human +DTXSID0040129 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040129 Fup 0.673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040129 Vd NA 0.4325 L/kg 1compartment NA NA Human Human DTXSID0040129 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040129 TK.Half.Life NA 0.342 hours 1compartment NA NA Human Human -DTXSID0040129 Css NA 0.00872 mg/L 3compartmentss NA 50% Human Human -DTXSID0040129 Css NA 0.08942 mg/L 3compartmentss NA 95% Human Human -DTXSID0040129 Css NA 0.006408 mg/L PBTK NA 50% Human Human -DTXSID0040129 Css NA 0.05919 mg/L PBTK NA 95% Human Human -DTXSID0040129 Clint NA 75.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040129 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040129 Vd NA 0.4986 L/kg 1compartment NA NA Rat Human +DTXSID0040129 TK.Half.Life NA 4.158 hours 1compartment NA NA Human Human +DTXSID0040129 Css NA 1.072 mg/L 3compartmentss NA 50% Human Human +DTXSID0040129 Css NA 6.634 mg/L 3compartmentss NA 95% Human Human +DTXSID0040129 Css NA 0.7804 mg/L PBTK NA 50% Human Human +DTXSID0040129 Css NA 4.015 mg/L PBTK NA 95% Human Human +DTXSID0040129 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040129 Fup 0.673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040129 Vd NA 0.4495 L/kg 1compartment NA NA Rat Human DTXSID0040129 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040129 TK.Half.Life NA 0.1584 hours 1compartment NA NA Rat Human -DTXSID0040129 Css NA 0.004525 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040129 Css NA 0.04278 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040129 Css NA 0.003254 mg/L PBTK NA 50% Rat Human -DTXSID0040129 Css NA 0.02747 mg/L PBTK NA 95% Rat Human -DTXSID0040208 Clint NA 7.467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040208 Fup NA 0.0834 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040208 Vd NA 0.4574 L/kg 1compartment NA NA Human Human +DTXSID0040129 TK.Half.Life NA 1.473 hours 1compartment NA NA Rat Human +DTXSID0040129 Css NA 0.02806 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040129 Css NA 0.2028 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040129 Css NA 0.01996 mg/L PBTK NA 50% Rat Human +DTXSID0040129 Css NA 0.1222 mg/L PBTK NA 95% Rat Human +DTXSID0040208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040208 Fup 0.0676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040208 Vd NA 0.9358 L/kg 1compartment NA NA Human Human DTXSID0040208 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040208 TK.Half.Life NA 2.974 hours 1compartment NA NA Human Human -DTXSID0040208 Css NA 0.9895 mg/L 3compartmentss NA 50% Human Human -DTXSID0040208 Css NA 6.84 mg/L 3compartmentss NA 95% Human Human -DTXSID0040208 Css NA 0.6122 mg/L PBTK NA 50% Human Human -DTXSID0040208 Css NA 4.116 mg/L PBTK NA 95% Human Human -DTXSID0040208 Clint NA 7.467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040208 Fup NA 0.0834 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040208 Vd NA 0.387 L/kg 1compartment NA NA Rat Human +DTXSID0040208 TK.Half.Life NA 3.245 hours 1compartment NA NA Human Human +DTXSID0040208 Css NA 0.3524 mg/L 3compartmentss NA 50% Human Human +DTXSID0040208 Css NA 2.538 mg/L 3compartmentss NA 95% Human Human +DTXSID0040208 Css NA 0.2234 mg/L PBTK NA 50% Human Human +DTXSID0040208 Css NA 1.554 mg/L PBTK NA 95% Human Human +DTXSID0040208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040208 Fup 0.0676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040208 Vd NA 0.7177 L/kg 1compartment NA NA Rat Human DTXSID0040208 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040208 TK.Half.Life NA 1.533 hours 1compartment NA NA Rat Human -DTXSID0040208 Css NA 0.5371 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040208 Css NA 2.725 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040208 Css NA 0.3104 mg/L PBTK NA 50% Rat Human -DTXSID0040208 Css NA 1.507 mg/L PBTK NA 95% Rat Human -DTXSID0040464 Clint NA 507.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0040208 TK.Half.Life NA 1.419 hours 1compartment NA NA Rat Human +DTXSID0040208 Css NA 0.01765 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040208 Css NA 0.1407 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040208 Css NA 0.01073 mg/L PBTK NA 50% Rat Human +DTXSID0040208 Css NA 0.08303 mg/L PBTK NA 95% Rat Human +DTXSID0040464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0040464 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0040464 Vd NA 0.5818 L/kg 1compartment NA NA Human Human +DTXSID0040464 Vd NA 0.6974 L/kg 1compartment NA NA Human Human DTXSID0040464 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040464 TK.Half.Life NA 0.649 hours 1compartment NA NA Human Human -DTXSID0040464 Css NA 0.03438 mg/L 3compartmentss NA 50% Human Human -DTXSID0040464 Css NA 0.3481 mg/L 3compartmentss NA 95% Human Human -DTXSID0040464 Css NA 0.02097 mg/L PBTK NA 50% Human Human -DTXSID0040464 Css NA 0.2086 mg/L PBTK NA 95% Human Human -DTXSID0040464 Clint NA 507.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0040464 TK.Half.Life NA 3.538 hours 1compartment NA NA Human Human +DTXSID0040464 Css NA 0.6545 mg/L 3compartmentss NA 50% Human Human +DTXSID0040464 Css NA 6.578 mg/L 3compartmentss NA 95% Human Human +DTXSID0040464 Css NA 0.4001 mg/L PBTK NA 50% Human Human +DTXSID0040464 Css NA 3.886 mg/L PBTK NA 95% Human Human +DTXSID0040464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0040464 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0040464 Vd NA 0.4637 L/kg 1compartment NA NA Rat Human +DTXSID0040464 Vd NA 0.5444 L/kg 1compartment NA NA Rat Human DTXSID0040464 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040464 TK.Half.Life NA 0.2465 hours 1compartment NA NA Rat Human -DTXSID0040464 Css NA 0.0201 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040464 Css NA 0.1693 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040464 Css NA 0.0114 mg/L PBTK NA 50% Rat Human -DTXSID0040464 Css NA 0.09425 mg/L PBTK NA 95% Rat Human -DTXSID0040547 Clint NA 0.1726 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040547 Fup NA 0.2247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040547 Vd NA 0.3636 L/kg 1compartment NA NA Human Human +DTXSID0040464 TK.Half.Life NA 1.682 hours 1compartment NA NA Rat Human +DTXSID0040464 Css NA 0.0332 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040464 Css NA 0.3381 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040464 Css NA 0.01937 mg/L PBTK NA 50% Rat Human +DTXSID0040464 Css NA 0.1914 mg/L PBTK NA 95% Rat Human +DTXSID0040547 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040547 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040547 Vd NA 0.4426 L/kg 1compartment NA NA Human Human DTXSID0040547 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040547 TK.Half.Life NA 7.933 hours 1compartment NA NA Human Human -DTXSID0040547 Css NA 2.617 mg/L 3compartmentss NA 50% Human Human -DTXSID0040547 Css NA 10.13 mg/L 3compartmentss NA 95% Human Human -DTXSID0040547 Css NA 1.733 mg/L PBTK NA 50% Human Human -DTXSID0040547 Css NA 6.213 mg/L PBTK NA 95% Human Human -DTXSID0040547 Clint NA 0.1726 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040547 Fup NA 0.2247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040547 Vd NA 0.3747 L/kg 1compartment NA NA Rat Human +DTXSID0040547 TK.Half.Life NA 9.238 hours 1compartment NA NA Human Human +DTXSID0040547 Css NA 1.307 mg/L 3compartmentss NA 50% Human Human +DTXSID0040547 Css NA 5.51 mg/L 3compartmentss NA 95% Human Human +DTXSID0040547 Css NA 0.9162 mg/L PBTK NA 50% Human Human +DTXSID0040547 Css NA 3.477 mg/L PBTK NA 95% Human Human +DTXSID0040547 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040547 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040547 Vd NA 0.4554 L/kg 1compartment NA NA Rat Human DTXSID0040547 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040547 TK.Half.Life NA 3.181 hours 1compartment NA NA Rat Human -DTXSID0040547 Css NA 0.8514 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040547 Css NA 2.744 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040547 Css NA 0.5331 mg/L PBTK NA 50% Rat Human -DTXSID0040547 Css NA 1.566 mg/L PBTK NA 95% Rat Human -DTXSID0040599 Clint NA 446.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040599 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040599 Vd NA 2.423 L/kg 1compartment NA NA Human Human -DTXSID0040599 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040599 TK.Half.Life NA 2.86 hours 1compartment NA NA Human Human -DTXSID0040599 Css NA 0.05208 mg/L 3compartmentss NA 50% Human Human -DTXSID0040599 Css NA 0.3902 mg/L 3compartmentss NA 95% Human Human -DTXSID0040599 Css NA 0.03476 mg/L PBTK NA 50% Human Human -DTXSID0040599 Css NA 0.2505 mg/L PBTK NA 95% Human Human -DTXSID0040599 Clint NA 446.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040599 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040599 Vd NA 1.815 L/kg 1compartment NA NA Rat Human -DTXSID0040599 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040599 TK.Half.Life NA 0.8822 hours 1compartment NA NA Rat Human -DTXSID0040599 Css NA 0.02993 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040599 Css NA 0.1831 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040599 Css NA 0.01884 mg/L PBTK NA 50% Rat Human -DTXSID0040599 Css NA 0.1131 mg/L PBTK NA 95% Rat Human -DTXSID0040620 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040620 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040620 Vd NA 0.552 L/kg 1compartment NA NA Human Human +DTXSID0040547 TK.Half.Life NA 3.239 hours 1compartment NA NA Rat Human +DTXSID0040547 Css NA 0.00708 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040547 Css NA 0.03058 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040547 Css NA 0.004704 mg/L PBTK NA 50% Rat Human +DTXSID0040547 Css NA 0.01834 mg/L PBTK NA 95% Rat Human +DTXSID0040599 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040599 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040599 Vd NA 3.121 L/kg 1compartment NA NA Human Human +DTXSID0040599 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID0040599 TK.Half.Life NA 55.14 hours 1compartment NA NA Human Human +DTXSID0040599 Css NA 2.018 mg/L 3compartmentss NA 50% Human Human +DTXSID0040599 Css NA 13.29 mg/L 3compartmentss NA 95% Human Human +DTXSID0040599 Css NA 1.4 mg/L PBTK NA 50% Human Human +DTXSID0040599 Css NA 8.979 mg/L PBTK NA 95% Human Human +DTXSID0040599 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040599 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040599 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID0040599 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0040599 TK.Half.Life NA 7.672 hours 1compartment NA NA Rat Human +DTXSID0040599 Css NA 0.2629 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040599 Css NA 1.449 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040599 Css NA 0.1815 mg/L PBTK NA 50% Rat Human +DTXSID0040599 Css NA 0.9818 mg/L PBTK NA 95% Rat Human +DTXSID0040620 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040620 Fup 0.858 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040620 Vd NA 0.5143 L/kg 1compartment NA NA Human Human DTXSID0040620 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040620 TK.Half.Life NA 3.573 hours 1compartment NA NA Human Human -DTXSID0040620 Css NA 0.9092 mg/L 3compartmentss NA 50% Human Human -DTXSID0040620 Css NA 5.666 mg/L 3compartmentss NA 95% Human Human -DTXSID0040620 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID0040620 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID0040620 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040620 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040620 Vd NA 0.5882 L/kg 1compartment NA NA Rat Human +DTXSID0040620 TK.Half.Life NA 3.879 hours 1compartment NA NA Human Human +DTXSID0040620 Css NA 0.576 mg/L 3compartmentss NA 50% Human Human +DTXSID0040620 Css NA 3.32 mg/L 3compartmentss NA 95% Human Human +DTXSID0040620 Css NA 0.4347 mg/L PBTK NA 50% Human Human +DTXSID0040620 Css NA 2.102 mg/L PBTK NA 95% Human Human +DTXSID0040620 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040620 Fup 0.858 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040620 Vd NA 0.5451 L/kg 1compartment NA NA Rat Human DTXSID0040620 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040620 TK.Half.Life NA 1.297 hours 1compartment NA NA Rat Human -DTXSID0040620 Css NA 0.2304 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040620 Css NA 1.369 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040620 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0040620 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0040622 Clint NA 2.993 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040622 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040622 Vd NA 1.779 L/kg 1compartment NA NA Human Human +DTXSID0040620 TK.Half.Life NA 1.401 hours 1compartment NA NA Rat Human +DTXSID0040620 Css NA 0.002946 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040620 Css NA 0.01802 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040620 Css NA 0.002146 mg/L PBTK NA 50% Rat Human +DTXSID0040620 Css NA 0.01091 mg/L PBTK NA 95% Rat Human +DTXSID0040622 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040622 Fup 0.547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040622 Vd NA 0.474 L/kg 1compartment NA NA Human Human DTXSID0040622 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040622 TK.Half.Life NA 2.907 hours 1compartment NA NA Human Human -DTXSID0040622 Css NA 0.1276 mg/L 3compartmentss NA 50% Human Human -DTXSID0040622 Css NA 1.112 mg/L 3compartmentss NA 95% Human Human -DTXSID0040622 Css NA 0.1254 mg/L PBTK NA 50% Human Human -DTXSID0040622 Css NA 0.8576 mg/L PBTK NA 95% Human Human -DTXSID0040622 Clint NA 2.993 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040622 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040622 Vd NA 1.576 L/kg 1compartment NA NA Rat Human +DTXSID0040622 TK.Half.Life NA 5.608 hours 1compartment NA NA Human Human +DTXSID0040622 Css NA 1.37 mg/L 3compartmentss NA 50% Human Human +DTXSID0040622 Css NA 8.526 mg/L 3compartmentss NA 95% Human Human +DTXSID0040622 Css NA 1.017 mg/L PBTK NA 50% Human Human +DTXSID0040622 Css NA 5.308 mg/L PBTK NA 95% Human Human +DTXSID0040622 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040622 Fup 0.547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040622 Vd NA 0.5118 L/kg 1compartment NA NA Rat Human DTXSID0040622 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040622 TK.Half.Life NA 1.221 hours 1compartment NA NA Rat Human -DTXSID0040622 Css NA 0.05569 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040622 Css NA 0.4289 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040622 Css NA 0.05473 mg/L PBTK NA 50% Rat Human -DTXSID0040622 Css NA 0.2807 mg/L PBTK NA 95% Rat Human -DTXSID0040672 Clint NA 11.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040672 Fup NA 0.0329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040672 Vd NA 0.8017 L/kg 1compartment NA NA Human Human +DTXSID0040622 TK.Half.Life NA 2.062 hours 1compartment NA NA Rat Human +DTXSID0040622 Css NA 0.08513 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040622 Css NA 0.4753 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040622 Css NA 0.0623 mg/L PBTK NA 50% Rat Human +DTXSID0040622 Css NA 0.2838 mg/L PBTK NA 95% Rat Human +DTXSID0040672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040672 Fup 0.0463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040672 Vd NA 0.9542 L/kg 1compartment NA NA Human Human DTXSID0040672 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040672 TK.Half.Life NA 7.923 hours 1compartment NA NA Human Human -DTXSID0040672 Css NA 1.67 mg/L 3compartmentss NA 50% Human Human -DTXSID0040672 Css NA 13.75 mg/L 3compartmentss NA 95% Human Human -DTXSID0040672 Css NA 1.014 mg/L PBTK NA 50% Human Human -DTXSID0040672 Css NA 8.045 mg/L PBTK NA 95% Human Human -DTXSID0040672 Clint NA 11.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040672 Fup NA 0.0329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040672 Vd NA 0.6117 L/kg 1compartment NA NA Rat Human +DTXSID0040672 TK.Half.Life NA 4.384 hours 1compartment NA NA Human Human +DTXSID0040672 Css NA 0.6472 mg/L 3compartmentss NA 50% Human Human +DTXSID0040672 Css NA 4.816 mg/L 3compartmentss NA 95% Human Human +DTXSID0040672 Css NA 0.4022 mg/L PBTK NA 50% Human Human +DTXSID0040672 Css NA 2.874 mg/L PBTK NA 95% Human Human +DTXSID0040672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040672 Fup 0.0463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040672 Vd NA 0.7287 L/kg 1compartment NA NA Rat Human DTXSID0040672 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040672 TK.Half.Life NA 3.658 hours 1compartment NA NA Rat Human -DTXSID0040672 Css NA 0.9315 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040672 Css NA 5.911 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040672 Css NA 0.5316 mg/L PBTK NA 50% Rat Human -DTXSID0040672 Css NA 3.273 mg/L PBTK NA 95% Rat Human -DTXSID0040674 Clint NA 13.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040674 Fup NA 0.0967 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040674 Vd NA 0.3467 L/kg 1compartment NA NA Human Human -DTXSID0040674 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040674 TK.Half.Life NA 1.274 hours 1compartment NA NA Human Human -DTXSID0040674 Css NA 0.4868 mg/L 3compartmentss NA 50% Human Human -DTXSID0040674 Css NA 3.612 mg/L 3compartmentss NA 95% Human Human -DTXSID0040674 Css NA 0.3027 mg/L PBTK NA 50% Human Human -DTXSID0040674 Css NA 2.188 mg/L PBTK NA 95% Human Human -DTXSID0040674 Clint NA 13.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040674 Fup NA 0.0967 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040674 Vd NA 0.3208 L/kg 1compartment NA NA Rat Human +DTXSID0040672 TK.Half.Life NA 1.942 hours 1compartment NA NA Rat Human +DTXSID0040672 Css NA 0.08389 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040672 Css NA 0.5113 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040672 Css NA 0.05032 mg/L PBTK NA 50% Rat Human +DTXSID0040672 Css NA 0.2973 mg/L PBTK NA 95% Rat Human +DTXSID0040674 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040674 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040674 Vd NA 0.5265 L/kg 1compartment NA NA Human Human +DTXSID0040674 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0040674 TK.Half.Life NA 14.64 hours 1compartment NA NA Human Human +DTXSID0040674 Css NA 3.164 mg/L 3compartmentss NA 50% Human Human +DTXSID0040674 Css NA 11.63 mg/L 3compartmentss NA 95% Human Human +DTXSID0040674 Css NA 2.206 mg/L PBTK NA 50% Human Human +DTXSID0040674 Css NA 7.323 mg/L PBTK NA 95% Human Human +DTXSID0040674 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040674 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040674 Vd NA 0.4875 L/kg 1compartment NA NA Rat Human DTXSID0040674 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040674 TK.Half.Life NA 0.7175 hours 1compartment NA NA Rat Human -DTXSID0040674 Css NA 0.2697 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040674 Css NA 1.514 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040674 Css NA 0.1571 mg/L PBTK NA 50% Rat Human -DTXSID0040674 Css NA 0.8436 mg/L PBTK NA 95% Rat Human +DTXSID0040674 TK.Half.Life NA 4.569 hours 1compartment NA NA Rat Human +DTXSID0040674 Css NA 0.2043 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040674 Css NA 0.6462 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040674 Css NA 0.1399 mg/L PBTK NA 50% Rat Human +DTXSID0040674 Css NA 0.3905 mg/L PBTK NA 95% Rat Human DTXSID0040676 Clint 1.597 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0040676 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0040676 Vd NA 0.1886 L/kg 1compartment NA NA Human Human DTXSID0040676 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID0040676 TK.Half.Life NA 16.8 hours 1compartment NA NA Human Human -DTXSID0040676 Css NA 16.36 mg/L 3compartmentss NA 50% Human Human -DTXSID0040676 Css NA 113.6 mg/L 3compartmentss NA 95% Human Human -DTXSID0040676 Css NA 9.386 mg/L PBTK NA 50% Human Human -DTXSID0040676 Css NA 64.91 mg/L PBTK NA 95% Human Human +DTXSID0040676 Css NA 14.78 mg/L 3compartmentss NA 50% Human Human +DTXSID0040676 Css NA 100.5 mg/L 3compartmentss NA 95% Human Human +DTXSID0040676 Css NA 8.124 mg/L PBTK NA 50% Human Human +DTXSID0040676 Css NA 55.28 mg/L PBTK NA 95% Human Human DTXSID0040676 Clint 1.597 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID0040676 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0040676 Vd NA 0.1843 L/kg 1compartment NA NA Rat Human DTXSID0040676 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0040676 TK.Half.Life NA 8.908 hours 1compartment NA NA Rat Human -DTXSID0040676 Css NA 7.467 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040676 Css NA 43.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040676 Css NA 3.966 mg/L PBTK NA 50% Rat Human -DTXSID0040676 Css NA 23.31 mg/L PBTK NA 95% Rat Human -DTXSID0040678 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040678 Fup NA 0.0845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040678 Vd NA 2.92 L/kg 1compartment NA NA Human Human -DTXSID0040678 Days.Css NA 119 Days PBTK NA NA Human Human -DTXSID0040678 TK.Half.Life NA 504.8 hours 1compartment NA NA Human Human -DTXSID0040678 Css NA 20.33 mg/L 3compartmentss NA 50% Human Human -DTXSID0040678 Css NA 75.32 mg/L 3compartmentss NA 95% Human Human -DTXSID0040678 Css NA 15.69 mg/L PBTK NA 50% Human Human -DTXSID0040678 Css NA 49.8 mg/L PBTK NA 95% Human Human -DTXSID0040678 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040678 Fup NA 0.0845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040678 Vd NA 2.442 L/kg 1compartment NA NA Rat Human -DTXSID0040678 Days.Css NA 32 Days PBTK NA NA Rat Human -DTXSID0040678 TK.Half.Life NA 82.81 hours 1compartment NA NA Rat Human -DTXSID0040678 Css NA 5.497 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040678 Css NA 17.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040678 Css NA 4.073 mg/L PBTK NA 50% Rat Human -DTXSID0040678 Css NA 10.71 mg/L PBTK NA 95% Rat Human -DTXSID0040701 Clint NA 79.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040701 Fup NA 0.5608 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040701 Vd NA 0.5068 L/kg 1compartment NA NA Human Human +DTXSID0040676 Css NA 0.5422 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040676 Css NA 4.638 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040676 Css NA 0.3022 mg/L PBTK NA 50% Rat Human +DTXSID0040676 Css NA 2.626 mg/L PBTK NA 95% Rat Human +DTXSID0040678 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040678 Fup 0.0585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040678 Vd NA 2.694 L/kg 1compartment NA NA Human Human +DTXSID0040678 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0040678 TK.Half.Life NA 9.681 hours 1compartment NA NA Human Human +DTXSID0040678 Css NA 0.383 mg/L 3compartmentss NA 50% Human Human +DTXSID0040678 Css NA 2.902 mg/L 3compartmentss NA 95% Human Human +DTXSID0040678 Css NA 0.2814 mg/L PBTK NA 50% Human Human +DTXSID0040678 Css NA 1.964 mg/L PBTK NA 95% Human Human +DTXSID0040678 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040678 Fup 0.0585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040678 Vd NA 2.223 L/kg 1compartment NA NA Rat Human +DTXSID0040678 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0040678 TK.Half.Life NA 3.345 hours 1compartment NA NA Rat Human +DTXSID0040678 Css NA 0.04984 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040678 Css NA 0.3051 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040678 Css NA 0.0363 mg/L PBTK NA 50% Rat Human +DTXSID0040678 Css NA 0.2075 mg/L PBTK NA 95% Rat Human +DTXSID0040701 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040701 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040701 Vd NA 0.4239 L/kg 1compartment NA NA Human Human DTXSID0040701 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0040701 TK.Half.Life NA 0.4009 hours 1compartment NA NA Human Human -DTXSID0040701 Css NA 0.01164 mg/L 3compartmentss NA 50% Human Human -DTXSID0040701 Css NA 0.1207 mg/L 3compartmentss NA 95% Human Human -DTXSID0040701 Css NA 0.008492 mg/L PBTK NA 50% Human Human -DTXSID0040701 Css NA 0.07855 mg/L PBTK NA 95% Human Human -DTXSID0040701 Clint NA 79.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040701 Fup NA 0.5608 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040701 Vd NA 0.5094 L/kg 1compartment NA NA Rat Human +DTXSID0040701 TK.Half.Life NA 0.5227 hours 1compartment NA NA Human Human +DTXSID0040701 Css NA 0.058 mg/L 3compartmentss NA 50% Human Human +DTXSID0040701 Css NA 0.4681 mg/L 3compartmentss NA 95% Human Human +DTXSID0040701 Css NA 0.0398 mg/L PBTK NA 50% Human Human +DTXSID0040701 Css NA 0.297 mg/L PBTK NA 95% Human Human +DTXSID0040701 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040701 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040701 Vd NA 0.421 L/kg 1compartment NA NA Rat Human DTXSID0040701 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0040701 TK.Half.Life NA 0.1831 hours 1compartment NA NA Rat Human -DTXSID0040701 Css NA 0.006204 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040701 Css NA 0.05506 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040701 Css NA 0.004355 mg/L PBTK NA 50% Rat Human -DTXSID0040701 Css NA 0.03488 mg/L PBTK NA 95% Rat Human -DTXSID0040703 Clint NA 1.517 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040703 Fup NA 0.0226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040703 Vd NA 0.2798 L/kg 1compartment NA NA Human Human -DTXSID0040703 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0040703 TK.Half.Life NA 22.56 hours 1compartment NA NA Human Human -DTXSID0040703 Css NA 14.07 mg/L 3compartmentss NA 50% Human Human -DTXSID0040703 Css NA 100.6 mg/L 3compartmentss NA 95% Human Human -DTXSID0040703 Css NA 8.448 mg/L PBTK NA 50% Human Human -DTXSID0040703 Css NA 58.9 mg/L PBTK NA 95% Human Human -DTXSID0040703 Clint NA 1.517 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040703 Fup NA 0.0226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040703 Vd NA 0.2596 L/kg 1compartment NA NA Rat Human -DTXSID0040703 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0040703 TK.Half.Life NA 11.28 hours 1compartment NA NA Rat Human -DTXSID0040703 Css NA 6.353 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040703 Css NA 38.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040703 Css NA 3.572 mg/L PBTK NA 50% Rat Human -DTXSID0040703 Css NA 20.93 mg/L PBTK NA 95% Rat Human -DTXSID0040705 Clint NA 3.504 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040705 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040705 Vd NA 0.2008 L/kg 1compartment NA NA Human Human -DTXSID0040705 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0040705 TK.Half.Life NA 24.73 hours 1compartment NA NA Human Human -DTXSID0040705 Css NA 22.7 mg/L 3compartmentss NA 50% Human Human -DTXSID0040705 Css NA 187.4 mg/L 3compartmentss NA 95% Human Human -DTXSID0040705 Css NA 13.3 mg/L PBTK NA 50% Human Human -DTXSID0040705 Css NA 106.7 mg/L PBTK NA 95% Human Human -DTXSID0040705 Clint NA 3.504 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040705 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040705 Vd NA 0.1897 L/kg 1compartment NA NA Rat Human -DTXSID0040705 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0040705 TK.Half.Life NA 14.19 hours 1compartment NA NA Rat Human -DTXSID0040705 Css NA 11.57 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040705 Css NA 72.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040705 Css NA 6.306 mg/L PBTK NA 50% Rat Human -DTXSID0040705 Css NA 39.47 mg/L PBTK NA 95% Rat Human +DTXSID0040701 TK.Half.Life NA 0.2685 hours 1compartment NA NA Rat Human +DTXSID0040701 Css NA 0.007299 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040701 Css NA 0.04266 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040701 Css NA 0.004971 mg/L PBTK NA 50% Rat Human +DTXSID0040701 Css NA 0.02699 mg/L PBTK NA 95% Rat Human +DTXSID0040703 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040703 Fup 0.0582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040703 Vd NA 0.4097 L/kg 1compartment NA NA Human Human +DTXSID0040703 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0040703 TK.Half.Life NA 1.553 hours 1compartment NA NA Human Human +DTXSID0040703 Css NA 0.4934 mg/L 3compartmentss NA 50% Human Human +DTXSID0040703 Css NA 4.361 mg/L 3compartmentss NA 95% Human Human +DTXSID0040703 Css NA 0.3104 mg/L PBTK NA 50% Human Human +DTXSID0040703 Css NA 2.587 mg/L PBTK NA 95% Human Human +DTXSID0040703 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040703 Fup 0.0582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040703 Vd NA 0.3784 L/kg 1compartment NA NA Rat Human +DTXSID0040703 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0040703 TK.Half.Life NA 0.89 hours 1compartment NA NA Rat Human +DTXSID0040703 Css NA 0.0657 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040703 Css NA 0.4186 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040703 Css NA 0.04044 mg/L PBTK NA 50% Rat Human +DTXSID0040703 Css NA 0.2455 mg/L PBTK NA 95% Rat Human +DTXSID0040705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040705 Fup 0.0173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040705 Vd NA 0.2409 L/kg 1compartment NA NA Human Human +DTXSID0040705 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0040705 TK.Half.Life NA 2.603 hours 1compartment NA NA Human Human +DTXSID0040705 Css NA 1.854 mg/L 3compartmentss NA 50% Human Human +DTXSID0040705 Css NA 18.51 mg/L 3compartmentss NA 95% Human Human +DTXSID0040705 Css NA 1.093 mg/L PBTK NA 50% Human Human +DTXSID0040705 Css NA 10.79 mg/L PBTK NA 95% Human Human +DTXSID0040705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040705 Fup 0.0173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040705 Vd NA 0.2238 L/kg 1compartment NA NA Rat Human +DTXSID0040705 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0040705 TK.Half.Life NA 1.595 hours 1compartment NA NA Rat Human +DTXSID0040705 Css NA 0.2436 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040705 Css NA 1.962 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040705 Css NA 0.1395 mg/L PBTK NA 50% Rat Human +DTXSID0040705 Css NA 1.112 mg/L PBTK NA 95% Rat Human DTXSID0040707 Clint 18.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0040707 Fup 0.0234 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0040707 Vd NA 1.471 L/kg 1compartment NA NA Human Human DTXSID0040707 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID0040707 TK.Half.Life NA 14.03 hours 1compartment NA NA Human Human -DTXSID0040707 Css NA 1.113 mg/L 3compartmentss NA 50% Human Human -DTXSID0040707 Css NA 7.879 mg/L 3compartmentss NA 95% Human Human -DTXSID0040707 Css NA 0.7133 mg/L PBTK NA 50% Human Human -DTXSID0040707 Css NA 4.801 mg/L PBTK NA 95% Human Human +DTXSID0040707 Css NA 1.088 mg/L 3compartmentss NA 50% Human Human +DTXSID0040707 Css NA 7.588 mg/L 3compartmentss NA 95% Human Human +DTXSID0040707 Css NA 0.6949 mg/L PBTK NA 50% Human Human +DTXSID0040707 Css NA 4.706 mg/L PBTK NA 95% Human Human DTXSID0040707 Clint 18.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0040707 Fup 0.0234 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0040707 Vd NA 1.096 L/kg 1compartment NA NA Rat Human DTXSID0040707 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0040707 TK.Half.Life NA 5.475 hours 1compartment NA NA Rat Human -DTXSID0040707 Css NA 0.6241 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040707 Css NA 3.274 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040707 Css NA 0.3762 mg/L PBTK NA 50% Rat Human -DTXSID0040707 Css NA 1.895 mg/L PBTK NA 95% Rat Human -DTXSID0040751 Clint NA 2.802 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040751 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040751 Vd NA 0.3657 L/kg 1compartment NA NA Human Human -DTXSID0040751 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID0040751 TK.Half.Life NA 31.84 hours 1compartment NA NA Human Human -DTXSID0040751 Css NA 15.94 mg/L 3compartmentss NA 50% Human Human -DTXSID0040751 Css NA 119 mg/L 3compartmentss NA 95% Human Human -DTXSID0040751 Css NA 9.394 mg/L PBTK NA 50% Human Human -DTXSID0040751 Css NA 70.26 mg/L PBTK NA 95% Human Human -DTXSID0040751 Clint NA 2.802 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040751 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040751 Vd NA 0.2967 L/kg 1compartment NA NA Rat Human -DTXSID0040751 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0040751 TK.Half.Life NA 15.21 hours 1compartment NA NA Rat Human -DTXSID0040751 Css NA 7.848 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040751 Css NA 46.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040751 Css NA 4.345 mg/L PBTK NA 50% Rat Human -DTXSID0040751 Css NA 25.51 mg/L PBTK NA 95% Rat Human +DTXSID0040707 Css NA 0.1392 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040707 Css NA 0.784 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040707 Css NA 0.08705 mg/L PBTK NA 50% Rat Human +DTXSID0040707 Css NA 0.467 mg/L PBTK NA 95% Rat Human +DTXSID0040751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040751 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040751 Vd NA 0.4462 L/kg 1compartment NA NA Human Human +DTXSID0040751 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0040751 TK.Half.Life NA 4.025 hours 1compartment NA NA Human Human +DTXSID0040751 Css NA 1.492 mg/L 3compartmentss NA 50% Human Human +DTXSID0040751 Css NA 14.39 mg/L 3compartmentss NA 95% Human Human +DTXSID0040751 Css NA 0.8974 mg/L PBTK NA 50% Human Human +DTXSID0040751 Css NA 8.371 mg/L PBTK NA 95% Human Human +DTXSID0040751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040751 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040751 Vd NA 0.3576 L/kg 1compartment NA NA Rat Human +DTXSID0040751 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0040751 TK.Half.Life NA 2.08 hours 1compartment NA NA Rat Human +DTXSID0040751 Css NA 0.1924 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040751 Css NA 1.562 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040751 Css NA 0.1114 mg/L PBTK NA 50% Rat Human +DTXSID0040751 Css NA 0.8848 mg/L PBTK NA 95% Rat Human DTXSID0040755 Clint 723 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0040755 Fup 0.00537 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0040755 Vd NA 2.25 L/kg 1compartment NA NA Human Human DTXSID0040755 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0040755 TK.Half.Life NA 3.415 hours 1compartment NA NA Human Human -DTXSID0040755 Css NA 0.09642 mg/L 3compartmentss NA 50% Human Human -DTXSID0040755 Css NA 0.7618 mg/L 3compartmentss NA 95% Human Human -DTXSID0040755 Css NA 0.06274 mg/L PBTK NA 50% Human Human -DTXSID0040755 Css NA 0.4785 mg/L PBTK NA 95% Human Human +DTXSID0040755 Css NA 0.09231 mg/L 3compartmentss NA 50% Human Human +DTXSID0040755 Css NA 0.7644 mg/L 3compartmentss NA 95% Human Human +DTXSID0040755 Css NA 0.05978 mg/L PBTK NA 50% Human Human +DTXSID0040755 Css NA 0.4768 mg/L PBTK NA 95% Human Human DTXSID0040755 Clint 723 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0040755 Fup 0.00537 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0040755 Vd NA 1.669 L/kg 1compartment NA NA Rat Human DTXSID0040755 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0040755 TK.Half.Life NA 1.05 hours 1compartment NA NA Rat Human -DTXSID0040755 Css NA 0.05574 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040755 Css NA 0.3553 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040755 Css NA 0.03423 mg/L PBTK NA 50% Rat Human -DTXSID0040755 Css NA 0.2077 mg/L PBTK NA 95% Rat Human -DTXSID0040757 Clint NA 1.051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040757 Fup NA 0.0205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040757 Vd NA 1.841 L/kg 1compartment NA NA Human Human -DTXSID0040757 Days.Css NA 56 Days PBTK NA NA Human Human -DTXSID0040757 TK.Half.Life NA 255.3 hours 1compartment NA NA Human Human -DTXSID0040757 Css NA 22.22 mg/L 3compartmentss NA 50% Human Human -DTXSID0040757 Css NA 122.4 mg/L 3compartmentss NA 95% Human Human -DTXSID0040757 Css NA 14.18 mg/L PBTK NA 50% Human Human -DTXSID0040757 Css NA 73.48 mg/L PBTK NA 95% Human Human -DTXSID0040757 Clint NA 1.051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040757 Fup NA 0.0205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040757 Vd NA 1.367 L/kg 1compartment NA NA Rat Human -DTXSID0040757 Days.Css NA 22 Days PBTK NA NA Rat Human -DTXSID0040757 TK.Half.Life NA 70.82 hours 1compartment NA NA Rat Human -DTXSID0040757 Css NA 9.858 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040757 Css NA 44.64 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040757 Css NA 5.942 mg/L PBTK NA 50% Rat Human -DTXSID0040757 Css NA 24.84 mg/L PBTK NA 95% Rat Human -DTXSID0040965 Clint NA 5.912 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040965 Fup NA 0.0644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0040965 Vd NA 3.103 L/kg 1compartment NA NA Human Human -DTXSID0040965 Days.Css NA 45 Days PBTK NA NA Human Human -DTXSID0040965 TK.Half.Life NA 220.6 hours 1compartment NA NA Human Human -DTXSID0040965 Css NA 8.724 mg/L 3compartmentss NA 50% Human Human -DTXSID0040965 Css NA 53.3 mg/L 3compartmentss NA 95% Human Human -DTXSID0040965 Css NA 6.062 mg/L PBTK NA 50% Human Human -DTXSID0040965 Css NA 36.49 mg/L PBTK NA 95% Human Human -DTXSID0040965 Clint NA 5.912 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040965 Fup NA 0.0644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0040965 Vd NA 2.326 L/kg 1compartment NA NA Rat Human -DTXSID0040965 Days.Css NA 25 Days PBTK NA NA Rat Human -DTXSID0040965 TK.Half.Life NA 29.45 hours 1compartment NA NA Rat Human -DTXSID0040965 Css NA 4.858 mg/L 3compartmentss NA 50% Rat Human -DTXSID0040965 Css NA 23.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID0040965 Css NA 3.234 mg/L PBTK NA 50% Rat Human -DTXSID0040965 Css NA 15.53 mg/L PBTK NA 95% Rat Human +DTXSID0040755 Css NA 0.0123 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040755 Css NA 0.08342 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040755 Css NA 0.007803 mg/L PBTK NA 50% Rat Human +DTXSID0040755 Css NA 0.05165 mg/L PBTK NA 95% Rat Human +DTXSID0040757 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040757 Fup 0.0154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0040757 Vd NA 1.918 L/kg 1compartment NA NA Human Human +DTXSID0040757 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0040757 TK.Half.Life NA 22.74 hours 1compartment NA NA Human Human +DTXSID0040757 Css NA 1.79 mg/L 3compartmentss NA 50% Human Human +DTXSID0040757 Css NA 15.02 mg/L 3compartmentss NA 95% Human Human +DTXSID0040757 Css NA 1.144 mg/L PBTK NA 50% Human Human +DTXSID0040757 Css NA 9.262 mg/L PBTK NA 95% Human Human +DTXSID0040757 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040757 Fup 0.0154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0040757 Vd NA 1.422 L/kg 1compartment NA NA Rat Human +DTXSID0040757 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0040757 TK.Half.Life NA 7.547 hours 1compartment NA NA Rat Human +DTXSID0040757 Css NA 0.2334 mg/L 3compartmentss NA 50% Rat Human +DTXSID0040757 Css NA 1.555 mg/L 3compartmentss NA 95% Rat Human +DTXSID0040757 Css NA 0.1453 mg/L PBTK NA 50% Rat Human +DTXSID0040757 Css NA 0.9292 mg/L PBTK NA 95% Rat Human DTXSID0041060 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0041060 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0041060 Vd NA 0.4607 L/kg 1compartment NA NA Human Human DTXSID0041060 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0041060 TK.Half.Life NA 0.8226 hours 1compartment NA NA Human Human -DTXSID0041060 Css NA 0.1532 mg/L 3compartmentss NA 50% Human Human -DTXSID0041060 Css NA 1.238 mg/L 3compartmentss NA 95% Human Human -DTXSID0041060 Css NA 0.1485 mg/L PBTK NA 50% Human Human -DTXSID0041060 Css NA 0.8812 mg/L PBTK NA 95% Human Human +DTXSID0041060 Css NA 0.1362 mg/L 3compartmentss NA 50% Human Human +DTXSID0041060 Css NA 0.8203 mg/L 3compartmentss NA 95% Human Human +DTXSID0041060 Css NA 0.1422 mg/L PBTK NA 50% Human Human +DTXSID0041060 Css NA 0.8588 mg/L PBTK NA 95% Human Human DTXSID0041060 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0041060 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0041060 Vd NA 0.4783 L/kg 1compartment NA NA Rat Human DTXSID0041060 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0041060 TK.Half.Life NA 0.4624 hours 1compartment NA NA Rat Human -DTXSID0041060 Css NA 0.06576 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041060 Css NA 0.5394 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041060 Css NA 0.06385 mg/L PBTK NA 50% Rat Human -DTXSID0041060 Css NA 0.3438 mg/L PBTK NA 95% Rat Human -DTXSID0041141 Clint NA 75.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041141 Fup NA 0.0878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041141 Vd NA 2.723 L/kg 1compartment NA NA Human Human +DTXSID0041060 Css NA 0.01299 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041060 Css NA 0.06967 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041060 Css NA 0.0141 mg/L PBTK NA 50% Rat Human +DTXSID0041060 Css NA 0.07567 mg/L PBTK NA 95% Rat Human +DTXSID0041068 Clint 0.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041068 Fup 0.0785 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041068 Vd NA 0.9991 L/kg 1compartment NA NA Human Human +DTXSID0041068 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0041068 TK.Half.Life NA 41.31 hours 1compartment NA NA Human Human +DTXSID0041068 Css NA 6.136 mg/L 3compartmentss NA 50% Human Human +DTXSID0041068 Css NA 29.75 mg/L 3compartmentss NA 95% Human Human +DTXSID0041068 Css NA 3.919 mg/L PBTK NA 50% Human Human +DTXSID0041068 Css NA 17.81 mg/L PBTK NA 95% Human Human +DTXSID0041068 Clint 0.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041068 Fup 0.0785 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041068 Vd NA 0.7763 L/kg 1compartment NA NA Rat Human +DTXSID0041068 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0041068 TK.Half.Life NA 13.87 hours 1compartment NA NA Rat Human +DTXSID0041068 Css NA 0.5671 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041068 Css NA 2.211 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041068 Css NA 0.3524 mg/L PBTK NA 50% Rat Human +DTXSID0041068 Css NA 1.279 mg/L PBTK NA 95% Rat Human +DTXSID0041141 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041141 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041141 Vd NA 2.771 L/kg 1compartment NA NA Human Human DTXSID0041141 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041141 TK.Half.Life NA 6.342 hours 1compartment NA NA Human Human -DTXSID0041141 Css NA 0.2118 mg/L 3compartmentss NA 50% Human Human -DTXSID0041141 Css NA 1.363 mg/L 3compartmentss NA 95% Human Human -DTXSID0041141 Css NA 0.1454 mg/L PBTK NA 50% Human Human -DTXSID0041141 Css NA 0.9272 mg/L PBTK NA 95% Human Human -DTXSID0041141 Clint NA 75.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041141 Fup NA 0.0878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041141 Vd NA 2.049 L/kg 1compartment NA NA Rat Human +DTXSID0041141 TK.Half.Life NA 12.16 hours 1compartment NA NA Human Human +DTXSID0041141 Css NA 0.455 mg/L 3compartmentss NA 50% Human Human +DTXSID0041141 Css NA 2.952 mg/L 3compartmentss NA 95% Human Human +DTXSID0041141 Css NA 0.322 mg/L PBTK NA 50% Human Human +DTXSID0041141 Css NA 1.981 mg/L PBTK NA 95% Human Human +DTXSID0041141 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041141 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041141 Vd NA 2.094 L/kg 1compartment NA NA Rat Human DTXSID0041141 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041141 TK.Half.Life NA 1.592 hours 1compartment NA NA Rat Human -DTXSID0041141 Css NA 0.1165 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041141 Css NA 0.6527 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041141 Css NA 0.07668 mg/L PBTK NA 50% Rat Human -DTXSID0041141 Css NA 0.4134 mg/L PBTK NA 95% Rat Human -DTXSID0041197 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041197 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041197 Vd NA 4.563 L/kg 1compartment NA NA Human Human -DTXSID0041197 Days.Css NA 1148 Days PBTK NA NA Human Human -DTXSID0041197 TK.Half.Life NA 4268 hours 1compartment NA NA Human Human -DTXSID0041197 Css NA 114.6 mg/L 3compartmentss NA 50% Human Human -DTXSID0041197 Css NA 620 mg/L 3compartmentss NA 95% Human Human -DTXSID0041197 Css NA 90.05 mg/L PBTK NA 50% Human Human -DTXSID0041197 Css NA 398.7 mg/L PBTK NA 95% Human Human -DTXSID0041197 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041197 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041197 Vd NA 3.489 L/kg 1compartment NA NA Rat Human -DTXSID0041197 Days.Css NA 297 Days PBTK NA NA Rat Human -DTXSID0041197 TK.Half.Life NA 761.7 hours 1compartment NA NA Rat Human -DTXSID0041197 Css NA 30.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041197 Css NA 150.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041197 Css NA 23.34 mg/L PBTK NA 50% Rat Human -DTXSID0041197 Css NA 89.74 mg/L PBTK NA 95% Rat Human -DTXSID0041220 Clint NA 0.3976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041220 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041220 Vd NA 1.425 L/kg 1compartment NA NA Human Human -DTXSID0041220 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041220 TK.Half.Life NA 6.145 hours 1compartment NA NA Human Human -DTXSID0041220 Css NA 0.4436 mg/L 3compartmentss NA 50% Human Human -DTXSID0041220 Css NA 3.24 mg/L 3compartmentss NA 95% Human Human -DTXSID0041220 Css NA 0.4204 mg/L PBTK NA 50% Human Human -DTXSID0041220 Css NA 2.157 mg/L PBTK NA 95% Human Human -DTXSID0041220 Clint NA 0.3976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041220 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041220 Vd NA 1.318 L/kg 1compartment NA NA Rat Human +DTXSID0041141 TK.Half.Life NA 2.731 hours 1compartment NA NA Rat Human +DTXSID0041141 Css NA 0.05774 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041141 Css NA 0.2873 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041141 Css NA 0.04044 mg/L PBTK NA 50% Rat Human +DTXSID0041141 Css NA 0.1965 mg/L PBTK NA 95% Rat Human +DTXSID0041145 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041145 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0041145 Vd NA 0.308 L/kg 1compartment NA NA Human Human +DTXSID0041145 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0041145 TK.Half.Life NA 0.9526 hours 1compartment NA NA Human Human +DTXSID0041145 Css NA 0.3054 mg/L 3compartmentss NA 50% Human Human +DTXSID0041145 Css NA 1.811 mg/L 3compartmentss NA 95% Human Human +DTXSID0041145 Css NA 0.1965 mg/L PBTK NA 50% Human Human +DTXSID0041145 Css NA 1.122 mg/L PBTK NA 95% Human Human +DTXSID0041145 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041145 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0041145 Vd NA 0.3108 L/kg 1compartment NA NA Rat Human +DTXSID0041145 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0041145 TK.Half.Life NA 0.5554 hours 1compartment NA NA Rat Human +DTXSID0041145 Css NA 0.03674 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041145 Css NA 0.1585 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041145 Css NA 0.02314 mg/L PBTK NA 50% Rat Human +DTXSID0041145 Css NA 0.09405 mg/L PBTK NA 95% Rat Human +DTXSID0041197 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041197 Fup 0.0336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041197 Vd NA 5.969 L/kg 1compartment NA NA Human Human +DTXSID0041197 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0041197 TK.Half.Life NA 51.08 hours 1compartment NA NA Human Human +DTXSID0041197 Css NA 0.896 mg/L 3compartmentss NA 50% Human Human +DTXSID0041197 Css NA 6.256 mg/L 3compartmentss NA 95% Human Human +DTXSID0041197 Css NA 0.7952 mg/L PBTK NA 50% Human Human +DTXSID0041197 Css NA 4.933 mg/L PBTK NA 95% Human Human +DTXSID0041197 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041197 Fup 0.0336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041197 Vd NA 4.618 L/kg 1compartment NA NA Rat Human +DTXSID0041197 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0041197 TK.Half.Life NA 13.68 hours 1compartment NA NA Rat Human +DTXSID0041197 Css NA 0.1095 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041197 Css NA 0.6403 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041197 Css NA 0.09983 mg/L PBTK NA 50% Rat Human +DTXSID0041197 Css NA 0.5329 mg/L PBTK NA 95% Rat Human +DTXSID0041220 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041220 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041220 Vd NA 0.9514 L/kg 1compartment NA NA Human Human +DTXSID0041220 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0041220 TK.Half.Life NA 11.24 hours 1compartment NA NA Human Human +DTXSID0041220 Css NA 1.238 mg/L 3compartmentss NA 50% Human Human +DTXSID0041220 Css NA 8.719 mg/L 3compartmentss NA 95% Human Human +DTXSID0041220 Css NA 1.02 mg/L PBTK NA 50% Human Human +DTXSID0041220 Css NA 5.591 mg/L PBTK NA 95% Human Human +DTXSID0041220 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041220 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041220 Vd NA 0.8884 L/kg 1compartment NA NA Rat Human DTXSID0041220 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041220 TK.Half.Life NA 2.258 hours 1compartment NA NA Rat Human -DTXSID0041220 Css NA 0.1419 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041220 Css NA 0.984 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041220 Css NA 0.1341 mg/L PBTK NA 50% Rat Human -DTXSID0041220 Css NA 0.6218 mg/L PBTK NA 95% Rat Human -DTXSID0041224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041224 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041224 Vd NA 0.8133 L/kg 1compartment NA NA Human Human +DTXSID0041220 TK.Half.Life NA 3.474 hours 1compartment NA NA Rat Human +DTXSID0041220 Css NA 0.0757 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041220 Css NA 0.4969 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041220 Css NA 0.0623 mg/L PBTK NA 50% Rat Human +DTXSID0041220 Css NA 0.3048 mg/L PBTK NA 95% Rat Human +DTXSID0041224 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041224 Fup 0.762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041224 Vd NA 0.6776 L/kg 1compartment NA NA Human Human DTXSID0041224 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041224 TK.Half.Life NA 5.267 hours 1compartment NA NA Human Human -DTXSID0041224 Css NA 0.8206 mg/L 3compartmentss NA 50% Human Human -DTXSID0041224 Css NA 5.484 mg/L 3compartmentss NA 95% Human Human -DTXSID0041224 Css NA 0.7004 mg/L PBTK NA 50% Human Human -DTXSID0041224 Css NA 3.55 mg/L PBTK NA 95% Human Human -DTXSID0041224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041224 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041224 Vd NA 0.8459 L/kg 1compartment NA NA Rat Human +DTXSID0041224 TK.Half.Life NA 5.757 hours 1compartment NA NA Human Human +DTXSID0041224 Css NA 0.8863 mg/L 3compartmentss NA 50% Human Human +DTXSID0041224 Css NA 5.615 mg/L 3compartmentss NA 95% Human Human +DTXSID0041224 Css NA 0.7207 mg/L PBTK NA 50% Human Human +DTXSID0041224 Css NA 3.636 mg/L PBTK NA 95% Human Human +DTXSID0041224 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041224 Fup 0.762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041224 Vd NA 0.7066 L/kg 1compartment NA NA Rat Human DTXSID0041224 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041224 TK.Half.Life NA 1.865 hours 1compartment NA NA Rat Human -DTXSID0041224 Css NA 0.2058 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041224 Css NA 1.313 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041224 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID0041224 Css NA 0.7933 mg/L PBTK NA 95% Rat Human -DTXSID0041274 Clint NA 1.884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041274 Fup NA 0.452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041274 Vd NA 0.8991 L/kg 1compartment NA NA Human Human +DTXSID0041224 TK.Half.Life NA 2.045 hours 1compartment NA NA Rat Human +DTXSID0041224 Css NA 0.01699 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041224 Css NA 0.1307 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041224 Css NA 0.01319 mg/L PBTK NA 50% Rat Human +DTXSID0041224 Css NA 0.08366 mg/L PBTK NA 95% Rat Human +DTXSID0041274 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041274 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041274 Vd NA 0.654 L/kg 1compartment NA NA Human Human DTXSID0041274 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041274 TK.Half.Life NA 3.556 hours 1compartment NA NA Human Human -DTXSID0041274 Css NA 0.3897 mg/L 3compartmentss NA 50% Human Human -DTXSID0041274 Css NA 2.287 mg/L 3compartmentss NA 95% Human Human -DTXSID0041274 Css NA 0.3086 mg/L PBTK NA 50% Human Human -DTXSID0041274 Css NA 1.519 mg/L PBTK NA 95% Human Human -DTXSID0041274 Clint NA 1.884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041274 Fup NA 0.452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041274 Vd NA 0.8282 L/kg 1compartment NA NA Rat Human +DTXSID0041274 TK.Half.Life NA 1.879 hours 1compartment NA NA Human Human +DTXSID0041274 Css NA 0.2636 mg/L 3compartmentss NA 50% Human Human +DTXSID0041274 Css NA 1.61 mg/L 3compartmentss NA 95% Human Human +DTXSID0041274 Css NA 0.1845 mg/L PBTK NA 50% Human Human +DTXSID0041274 Css NA 1.042 mg/L PBTK NA 95% Human Human +DTXSID0041274 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041274 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041274 Vd NA 0.5999 L/kg 1compartment NA NA Rat Human DTXSID0041274 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041274 TK.Half.Life NA 1.694 hours 1compartment NA NA Rat Human -DTXSID0041274 Css NA 0.1714 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041274 Css NA 0.7843 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041274 Css NA 0.1313 mg/L PBTK NA 50% Rat Human -DTXSID0041274 Css NA 0.4805 mg/L PBTK NA 95% Rat Human -DTXSID0041359 Clint NA 11.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041359 Fup NA 0.0383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041359 Vd NA 0.6875 L/kg 1compartment NA NA Human Human +DTXSID0041274 TK.Half.Life NA 0.9851 hours 1compartment NA NA Rat Human +DTXSID0041274 Css NA 0.03186 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041274 Css NA 0.1388 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041274 Css NA 0.02212 mg/L PBTK NA 50% Rat Human +DTXSID0041274 Css NA 0.08817 mg/L PBTK NA 95% Rat Human +DTXSID0041359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041359 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041359 Vd NA 1.319 L/kg 1compartment NA NA Human Human DTXSID0041359 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041359 TK.Half.Life NA 6.102 hours 1compartment NA NA Human Human -DTXSID0041359 Css NA 1.508 mg/L 3compartmentss NA 50% Human Human -DTXSID0041359 Css NA 12.97 mg/L 3compartmentss NA 95% Human Human -DTXSID0041359 Css NA 0.9259 mg/L PBTK NA 50% Human Human -DTXSID0041359 Css NA 7.545 mg/L PBTK NA 95% Human Human -DTXSID0041359 Clint NA 11.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041359 Fup NA 0.0383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041359 Vd NA 0.5334 L/kg 1compartment NA NA Rat Human +DTXSID0041359 TK.Half.Life NA 4.581 hours 1compartment NA NA Human Human +DTXSID0041359 Css NA 0.4132 mg/L 3compartmentss NA 50% Human Human +DTXSID0041359 Css NA 3.125 mg/L 3compartmentss NA 95% Human Human +DTXSID0041359 Css NA 0.2669 mg/L PBTK NA 50% Human Human +DTXSID0041359 Css NA 1.926 mg/L PBTK NA 95% Human Human +DTXSID0041359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041359 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041359 Vd NA 1.003 L/kg 1compartment NA NA Rat Human DTXSID0041359 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041359 TK.Half.Life NA 2.904 hours 1compartment NA NA Rat Human -DTXSID0041359 Css NA 0.8232 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041359 Css NA 5.478 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041359 Css NA 0.4693 mg/L PBTK NA 50% Rat Human -DTXSID0041359 Css NA 3.034 mg/L PBTK NA 95% Rat Human -DTXSID0041436 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041436 Fup NA 0.8577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041436 Vd NA 1.185 L/kg 1compartment NA NA Human Human -DTXSID0041436 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041436 TK.Half.Life NA 9.372 hours 1compartment NA NA Human Human -DTXSID0041436 Css NA 0.8944 mg/L 3compartmentss NA 50% Human Human -DTXSID0041436 Css NA 5.689 mg/L 3compartmentss NA 95% Human Human -DTXSID0041436 Css NA 0.7996 mg/L PBTK NA 50% Human Human -DTXSID0041436 Css NA 3.756 mg/L PBTK NA 95% Human Human -DTXSID0041436 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041436 Fup NA 0.8577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041436 Vd NA 1.123 L/kg 1compartment NA NA Rat Human +DTXSID0041359 TK.Half.Life NA 1.851 hours 1compartment NA NA Rat Human +DTXSID0041359 Css NA 0.05444 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041359 Css NA 0.323 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041359 Css NA 0.03419 mg/L PBTK NA 50% Rat Human +DTXSID0041359 Css NA 0.1951 mg/L PBTK NA 95% Rat Human +DTXSID0041436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041436 Fup 0.63 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041436 Vd NA 0.9841 L/kg 1compartment NA NA Human Human +DTXSID0041436 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0041436 TK.Half.Life NA 10.47 hours 1compartment NA NA Human Human +DTXSID0041436 Css NA 0.9776 mg/L 3compartmentss NA 50% Human Human +DTXSID0041436 Css NA 6.728 mg/L 3compartmentss NA 95% Human Human +DTXSID0041436 Css NA 0.8289 mg/L PBTK NA 50% Human Human +DTXSID0041436 Css NA 4.312 mg/L PBTK NA 95% Human Human +DTXSID0041436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041436 Fup 0.63 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041436 Vd NA 0.9301 L/kg 1compartment NA NA Rat Human DTXSID0041436 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041436 TK.Half.Life NA 2.921 hours 1compartment NA NA Rat Human -DTXSID0041436 Css NA 0.2283 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041436 Css NA 1.395 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041436 Css NA 0.2005 mg/L PBTK NA 50% Rat Human -DTXSID0041436 Css NA 0.8629 mg/L PBTK NA 95% Rat Human -DTXSID0041513 Clint NA 2.647 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041513 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041513 Vd NA 0.8597 L/kg 1compartment NA NA Human Human +DTXSID0041436 TK.Half.Life NA 3.282 hours 1compartment NA NA Rat Human +DTXSID0041436 Css NA 0.01861 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041436 Css NA 0.1615 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041436 Css NA 0.01516 mg/L PBTK NA 50% Rat Human +DTXSID0041436 Css NA 0.1046 mg/L PBTK NA 95% Rat Human +DTXSID0041513 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041513 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041513 Vd NA 0.5536 L/kg 1compartment NA NA Human Human DTXSID0041513 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041513 TK.Half.Life NA 1.351 hours 1compartment NA NA Human Human -DTXSID0041513 Css NA 0.1566 mg/L 3compartmentss NA 50% Human Human -DTXSID0041513 Css NA 1.204 mg/L 3compartmentss NA 95% Human Human -DTXSID0041513 Css NA 0.133 mg/L PBTK NA 50% Human Human -DTXSID0041513 Css NA 0.8562 mg/L PBTK NA 95% Human Human -DTXSID0041513 Clint NA 2.647 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041513 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041513 Vd NA 0.8858 L/kg 1compartment NA NA Rat Human +DTXSID0041513 TK.Half.Life NA 7.582 hours 1compartment NA NA Human Human +DTXSID0041513 Css NA 1.303 mg/L 3compartmentss NA 50% Human Human +DTXSID0041513 Css NA 6.23 mg/L 3compartmentss NA 95% Human Human +DTXSID0041513 Css NA 0.974 mg/L PBTK NA 50% Human Human +DTXSID0041513 Css NA 3.954 mg/L PBTK NA 95% Human Human +DTXSID0041513 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041513 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041513 Vd NA 0.5681 L/kg 1compartment NA NA Rat Human DTXSID0041513 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041513 TK.Half.Life NA 0.7237 hours 1compartment NA NA Rat Human -DTXSID0041513 Css NA 0.06718 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041513 Css NA 0.4561 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041513 Css NA 0.05697 mg/L PBTK NA 50% Rat Human -DTXSID0041513 Css NA 0.281 mg/L PBTK NA 95% Rat Human -DTXSID0041517 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041517 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041517 Vd NA 0.9537 L/kg 1compartment NA NA Human Human +DTXSID0041513 TK.Half.Life NA 2.649 hours 1compartment NA NA Rat Human +DTXSID0041513 Css NA 0.02428 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041513 Css NA 0.1636 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041513 Css NA 0.01749 mg/L PBTK NA 50% Rat Human +DTXSID0041513 Css NA 0.1051 mg/L PBTK NA 95% Rat Human +DTXSID0041517 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041517 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041517 Vd NA 1.089 L/kg 1compartment NA NA Human Human DTXSID0041517 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041517 TK.Half.Life NA 6.217 hours 1compartment NA NA Human Human -DTXSID0041517 Css NA 0.7869 mg/L 3compartmentss NA 50% Human Human -DTXSID0041517 Css NA 5.54 mg/L 3compartmentss NA 95% Human Human -DTXSID0041517 Css NA 0.6938 mg/L PBTK NA 50% Human Human -DTXSID0041517 Css NA 3.764 mg/L PBTK NA 95% Human Human -DTXSID0041517 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041517 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041517 Vd NA 0.9641 L/kg 1compartment NA NA Rat Human +DTXSID0041517 TK.Half.Life NA 0.8794 hours 1compartment NA NA Human Human +DTXSID0041517 Css NA 0.02706 mg/L 3compartmentss NA 50% Human Human +DTXSID0041517 Css NA 0.3114 mg/L 3compartmentss NA 95% Human Human +DTXSID0041517 Css NA 0.02298 mg/L PBTK NA 50% Human Human +DTXSID0041517 Css NA 0.2263 mg/L PBTK NA 95% Human Human +DTXSID0041517 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041517 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041517 Vd NA 1.024 L/kg 1compartment NA NA Rat Human DTXSID0041517 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041517 TK.Half.Life NA 2.129 hours 1compartment NA NA Rat Human -DTXSID0041517 Css NA 0.1992 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041517 Css NA 1.264 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041517 Css NA 0.1727 mg/L PBTK NA 50% Rat Human -DTXSID0041517 Css NA 0.7745 mg/L PBTK NA 95% Rat Human -DTXSID0041567 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041567 Fup NA 0.0164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041567 Vd NA 2.365 L/kg 1compartment NA NA Human Human -DTXSID0041567 Days.Css NA 641 Days PBTK NA NA Human Human -DTXSID0041567 TK.Half.Life NA 2407 hours 1compartment NA NA Human Human -DTXSID0041567 Css NA 140.6 mg/L 3compartmentss NA 50% Human Human -DTXSID0041567 Css NA 568 mg/L 3compartmentss NA 95% Human Human -DTXSID0041567 Css NA 93.84 mg/L PBTK NA 50% Human Human -DTXSID0041567 Css NA 347.5 mg/L PBTK NA 95% Human Human -DTXSID0041567 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041567 Fup NA 0.0164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041567 Vd NA 1.766 L/kg 1compartment NA NA Rat Human -DTXSID0041567 Days.Css NA 160 Days PBTK NA NA Rat Human -DTXSID0041567 TK.Half.Life NA 327 hours 1compartment NA NA Rat Human -DTXSID0041567 Css NA 38.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041567 Css NA 132.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041567 Css NA 24.35 mg/L PBTK NA 50% Rat Human -DTXSID0041567 Css NA 75.43 mg/L PBTK NA 95% Rat Human -DTXSID0041646 Clint NA 3.119 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041646 Fup NA 0.0163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041646 Vd NA 0.2603 L/kg 1compartment NA NA Human Human -DTXSID0041646 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0041646 TK.Half.Life NA 16.83 hours 1compartment NA NA Human Human -DTXSID0041646 Css NA 11.76 mg/L 3compartmentss NA 50% Human Human -DTXSID0041646 Css NA 89.49 mg/L 3compartmentss NA 95% Human Human -DTXSID0041646 Css NA 7.062 mg/L PBTK NA 50% Human Human -DTXSID0041646 Css NA 52.28 mg/L PBTK NA 95% Human Human -DTXSID0041646 Clint NA 3.119 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041646 Fup NA 0.0163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041646 Vd NA 0.2518 L/kg 1compartment NA NA Rat Human -DTXSID0041646 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0041646 TK.Half.Life NA 9.712 hours 1compartment NA NA Rat Human -DTXSID0041646 Css NA 5.712 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041646 Css NA 37.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041646 Css NA 3.189 mg/L PBTK NA 50% Rat Human -DTXSID0041646 Css NA 20.14 mg/L PBTK NA 95% Rat Human -DTXSID0041692 Clint NA 10.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041692 Fup NA 0.8936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041692 Vd NA 0.9472 L/kg 1compartment NA NA Human Human +DTXSID0041517 TK.Half.Life NA 0.4028 hours 1compartment NA NA Rat Human +DTXSID0041517 Css NA 0.003235 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041517 Css NA 0.0309 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041517 Css NA 0.002848 mg/L PBTK NA 50% Rat Human +DTXSID0041517 Css NA 0.02078 mg/L PBTK NA 95% Rat Human +DTXSID0041567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041567 Fup 0.0563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041567 Vd NA 2.795 L/kg 1compartment NA NA Human Human +DTXSID0041567 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0041567 TK.Half.Life NA 24.7 hours 1compartment NA NA Human Human +DTXSID0041567 Css NA 1.054 mg/L 3compartmentss NA 50% Human Human +DTXSID0041567 Css NA 6.965 mg/L 3compartmentss NA 95% Human Human +DTXSID0041567 Css NA 0.7316 mg/L PBTK NA 50% Human Human +DTXSID0041567 Css NA 4.65 mg/L PBTK NA 95% Human Human +DTXSID0041567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041567 Fup 0.0563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041567 Vd NA 2.102 L/kg 1compartment NA NA Rat Human +DTXSID0041567 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0041567 TK.Half.Life NA 5.059 hours 1compartment NA NA Rat Human +DTXSID0041567 Css NA 0.1347 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041567 Css NA 0.7399 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041567 Css NA 0.09322 mg/L PBTK NA 50% Rat Human +DTXSID0041567 Css NA 0.4945 mg/L PBTK NA 95% Rat Human +DTXSID0041646 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041646 Fup 0.0855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041646 Vd NA 0.3459 L/kg 1compartment NA NA Human Human +DTXSID0041646 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0041646 TK.Half.Life NA 2.55 hours 1compartment NA NA Human Human +DTXSID0041646 Css NA 0.9684 mg/L 3compartmentss NA 50% Human Human +DTXSID0041646 Css NA 6.827 mg/L 3compartmentss NA 95% Human Human +DTXSID0041646 Css NA 0.5974 mg/L PBTK NA 50% Human Human +DTXSID0041646 Css NA 4.02 mg/L PBTK NA 95% Human Human +DTXSID0041646 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041646 Fup 0.0855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041646 Vd NA 0.3234 L/kg 1compartment NA NA Rat Human +DTXSID0041646 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0041646 TK.Half.Life NA 1.46 hours 1compartment NA NA Rat Human +DTXSID0041646 Css NA 0.04366 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041646 Css NA 0.3411 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041646 Css NA 0.02572 mg/L PBTK NA 50% Rat Human +DTXSID0041646 Css NA 0.1928 mg/L PBTK NA 95% Rat Human +DTXSID0041692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041692 Fup 0.756 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041692 Vd NA 0.8878 L/kg 1compartment NA NA Human Human DTXSID0041692 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041692 TK.Half.Life NA 0.8348 hours 1compartment NA NA Human Human -DTXSID0041692 Css NA 0.05065 mg/L 3compartmentss NA 50% Human Human -DTXSID0041692 Css NA 0.4418 mg/L 3compartmentss NA 95% Human Human -DTXSID0041692 Css NA 0.04273 mg/L PBTK NA 50% Human Human -DTXSID0041692 Css NA 0.3129 mg/L PBTK NA 95% Human Human -DTXSID0041692 Clint NA 10.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041692 Fup NA 0.8936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041692 Vd NA 0.9423 L/kg 1compartment NA NA Rat Human +DTXSID0041692 TK.Half.Life NA 0.7028 hours 1compartment NA NA Human Human +DTXSID0041692 Css NA 0.02689 mg/L 3compartmentss NA 50% Human Human +DTXSID0041692 Css NA 0.2804 mg/L 3compartmentss NA 95% Human Human +DTXSID0041692 Css NA 0.02222 mg/L PBTK NA 50% Human Human +DTXSID0041692 Css NA 0.2012 mg/L PBTK NA 95% Human Human +DTXSID0041692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041692 Fup 0.756 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041692 Vd NA 0.8795 L/kg 1compartment NA NA Rat Human DTXSID0041692 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041692 TK.Half.Life NA 0.4196 hours 1compartment NA NA Rat Human -DTXSID0041692 Css NA 0.02434 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041692 Css NA 0.1904 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041692 Css NA 0.02062 mg/L PBTK NA 50% Rat Human -DTXSID0041692 Css NA 0.1258 mg/L PBTK NA 95% Rat Human -DTXSID0041698 Clint NA 17.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041698 Fup NA 0.9096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041698 Vd NA 0.5546 L/kg 1compartment NA NA Human Human +DTXSID0041692 TK.Half.Life NA 0.3389 hours 1compartment NA NA Rat Human +DTXSID0041692 Css NA 0.003128 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041692 Css NA 0.02921 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041692 Css NA 0.002701 mg/L PBTK NA 50% Rat Human +DTXSID0041692 Css NA 0.02025 mg/L PBTK NA 95% Rat Human +DTXSID0041698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041698 Fup 0.861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041698 Vd NA 0.5393 L/kg 1compartment NA NA Human Human DTXSID0041698 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041698 TK.Half.Life NA 0.4486 hours 1compartment NA NA Human Human -DTXSID0041698 Css NA 0.03314 mg/L 3compartmentss NA 50% Human Human -DTXSID0041698 Css NA 0.3037 mg/L 3compartmentss NA 95% Human Human -DTXSID0041698 Css NA 0.0252 mg/L PBTK NA 50% Human Human -DTXSID0041698 Css NA 0.2081 mg/L PBTK NA 95% Human Human -DTXSID0041698 Clint NA 17.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041698 Fup NA 0.9096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041698 Vd NA 0.5744 L/kg 1compartment NA NA Rat Human +DTXSID0041698 TK.Half.Life NA 4.051 hours 1compartment NA NA Human Human +DTXSID0041698 Css NA 0.9794 mg/L 3compartmentss NA 50% Human Human +DTXSID0041698 Css NA 5.652 mg/L 3compartmentss NA 95% Human Human +DTXSID0041698 Css NA 0.7598 mg/L PBTK NA 50% Human Human +DTXSID0041698 Css NA 3.604 mg/L PBTK NA 95% Human Human +DTXSID0041698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041698 Fup 0.861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041698 Vd NA 0.5582 L/kg 1compartment NA NA Rat Human DTXSID0041698 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041698 TK.Half.Life NA 0.2228 hours 1compartment NA NA Rat Human -DTXSID0041698 Css NA 0.01663 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041698 Css NA 0.1283 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041698 Css NA 0.01243 mg/L PBTK NA 50% Rat Human -DTXSID0041698 Css NA 0.0822 mg/L PBTK NA 95% Rat Human -DTXSID0041721 Clint NA 3.013 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041721 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041721 Vd NA 0.2729 L/kg 1compartment NA NA Human Human -DTXSID0041721 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041721 TK.Half.Life NA 2.265 hours 1compartment NA NA Human Human -DTXSID0041721 Css NA 1.247 mg/L 3compartmentss NA 50% Human Human -DTXSID0041721 Css NA 7.814 mg/L 3compartmentss NA 95% Human Human -DTXSID0041721 Css NA 0.7719 mg/L PBTK NA 50% Human Human -DTXSID0041721 Css NA 4.66 mg/L PBTK NA 95% Human Human -DTXSID0041721 Clint NA 3.013 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041721 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041721 Vd NA 0.2801 L/kg 1compartment NA NA Rat Human -DTXSID0041721 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041721 TK.Half.Life NA 1.366 hours 1compartment NA NA Rat Human -DTXSID0041721 Css NA 0.6271 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041721 Css NA 2.949 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041721 Css NA 0.3631 mg/L PBTK NA 50% Rat Human -DTXSID0041721 Css NA 1.631 mg/L PBTK NA 95% Rat Human -DTXSID0041850 Clint NA 90.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041850 Fup NA 0.0362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041850 Vd NA 2.045 L/kg 1compartment NA NA Human Human -DTXSID0041850 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041850 TK.Half.Life NA 4.774 hours 1compartment NA NA Human Human -DTXSID0041850 Css NA 0.242 mg/L 3compartmentss NA 50% Human Human -DTXSID0041850 Css NA 1.873 mg/L 3compartmentss NA 95% Human Human -DTXSID0041850 Css NA 0.1572 mg/L PBTK NA 50% Human Human -DTXSID0041850 Css NA 1.18 mg/L PBTK NA 95% Human Human -DTXSID0041850 Clint NA 90.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041850 Fup NA 0.0362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041850 Vd NA 1.527 L/kg 1compartment NA NA Rat Human +DTXSID0041698 TK.Half.Life NA 1.429 hours 1compartment NA NA Rat Human +DTXSID0041698 Css NA 0.05902 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041698 Css NA 0.3215 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041698 Css NA 0.04543 mg/L PBTK NA 50% Rat Human +DTXSID0041698 Css NA 0.1956 mg/L PBTK NA 95% Rat Human +DTXSID0041850 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041850 Fup 0.0416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041850 Vd NA 2.134 L/kg 1compartment NA NA Human Human +DTXSID0041850 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0041850 TK.Half.Life NA 13.93 hours 1compartment NA NA Human Human +DTXSID0041850 Css NA 0.8988 mg/L 3compartmentss NA 50% Human Human +DTXSID0041850 Css NA 6.502 mg/L 3compartmentss NA 95% Human Human +DTXSID0041850 Css NA 0.5868 mg/L PBTK NA 50% Human Human +DTXSID0041850 Css NA 4.091 mg/L PBTK NA 95% Human Human +DTXSID0041850 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041850 Fup 0.0416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041850 Vd NA 1.596 L/kg 1compartment NA NA Rat Human DTXSID0041850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041850 TK.Half.Life NA 1.542 hours 1compartment NA NA Rat Human -DTXSID0041850 Css NA 0.1377 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041850 Css NA 0.8128 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041850 Css NA 0.08441 mg/L PBTK NA 50% Rat Human -DTXSID0041850 Css NA 0.4881 mg/L PBTK NA 95% Rat Human -DTXSID0041852 Clint NA 0.3097 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041852 Fup NA 0.0884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041852 Vd NA 0.2813 L/kg 1compartment NA NA Human Human +DTXSID0041850 TK.Half.Life NA 4.273 hours 1compartment NA NA Rat Human +DTXSID0041850 Css NA 0.1156 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041850 Css NA 0.6574 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041850 Css NA 0.07408 mg/L PBTK NA 50% Rat Human +DTXSID0041850 Css NA 0.4053 mg/L PBTK NA 95% Rat Human +DTXSID0041852 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041852 Fup 0.41 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041852 Vd NA 0.6176 L/kg 1compartment NA NA Human Human DTXSID0041852 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0041852 TK.Half.Life NA 13.63 hours 1compartment NA NA Human Human -DTXSID0041852 Css NA 7.674 mg/L 3compartmentss NA 50% Human Human -DTXSID0041852 Css NA 36.34 mg/L 3compartmentss NA 95% Human Human -DTXSID0041852 Css NA 4.662 mg/L PBTK NA 50% Human Human -DTXSID0041852 Css NA 21.16 mg/L PBTK NA 95% Human Human -DTXSID0041852 Clint NA 0.3097 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041852 Fup NA 0.0884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041852 Vd NA 0.2732 L/kg 1compartment NA NA Rat Human +DTXSID0041852 TK.Half.Life NA 9.857 hours 1compartment NA NA Human Human +DTXSID0041852 Css NA 1.728 mg/L 3compartmentss NA 50% Human Human +DTXSID0041852 Css NA 7.746 mg/L 3compartmentss NA 95% Human Human +DTXSID0041852 Css NA 1.277 mg/L PBTK NA 50% Human Human +DTXSID0041852 Css NA 4.862 mg/L PBTK NA 95% Human Human +DTXSID0041852 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041852 Fup 0.41 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041852 Vd NA 0.5951 L/kg 1compartment NA NA Rat Human DTXSID0041852 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041852 TK.Half.Life NA 5.458 hours 1compartment NA NA Rat Human -DTXSID0041852 Css NA 2.694 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041852 Css NA 10.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041852 Css NA 1.532 mg/L PBTK NA 50% Rat Human -DTXSID0041852 Css NA 5.795 mg/L PBTK NA 95% Rat Human +DTXSID0041852 TK.Half.Life NA 3.211 hours 1compartment NA NA Rat Human +DTXSID0041852 Css NA 0.1109 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041852 Css NA 0.4103 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041852 Css NA 0.08088 mg/L PBTK NA 50% Rat Human +DTXSID0041852 Css NA 0.2519 mg/L PBTK NA 95% Rat Human DTXSID0041981 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0041981 Fup NA 0.3424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041981 Vd NA 0.4241 L/kg 1compartment NA NA Human Human +DTXSID0041981 Vd NA 0.422 L/kg 1compartment NA NA Human Human DTXSID0041981 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041981 TK.Half.Life NA 8.014 hours 1compartment NA NA Human Human -DTXSID0041981 Css NA 2.217 mg/L 3compartmentss NA 50% Human Human -DTXSID0041981 Css NA 8.864 mg/L 3compartmentss NA 95% Human Human -DTXSID0041981 Css NA 1.561 mg/L PBTK NA 50% Human Human -DTXSID0041981 Css NA 5.526 mg/L PBTK NA 95% Human Human +DTXSID0041981 TK.Half.Life NA 7.975 hours 1compartment NA NA Human Human +DTXSID0041981 Css NA 1.858 mg/L 3compartmentss NA 50% Human Human +DTXSID0041981 Css NA 7.581 mg/L 3compartmentss NA 95% Human Human +DTXSID0041981 Css NA 1.304 mg/L PBTK NA 50% Human Human +DTXSID0041981 Css NA 4.737 mg/L PBTK NA 95% Human Human DTXSID0041981 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0041981 Fup NA 0.3424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041981 Vd NA 0.4369 L/kg 1compartment NA NA Rat Human +DTXSID0041981 Vd NA 0.435 L/kg 1compartment NA NA Rat Human DTXSID0041981 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041981 TK.Half.Life NA 2.814 hours 1compartment NA NA Rat Human -DTXSID0041981 Css NA 0.6071 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041981 Css NA 2.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041981 Css NA 0.405 mg/L PBTK NA 50% Rat Human -DTXSID0041981 Css NA 1.223 mg/L PBTK NA 95% Rat Human -DTXSID0041983 Clint NA 137.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041983 Fup NA 0.0103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041983 Vd NA 0.3759 L/kg 1compartment NA NA Human Human -DTXSID0041983 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041983 TK.Half.Life NA 1.298 hours 1compartment NA NA Human Human -DTXSID0041983 Css NA 0.48 mg/L 3compartmentss NA 50% Human Human -DTXSID0041983 Css NA 5.1 mg/L 3compartmentss NA 95% Human Human -DTXSID0041983 Css NA 0.2815 mg/L PBTK NA 50% Human Human -DTXSID0041983 Css NA 2.961 mg/L PBTK NA 95% Human Human -DTXSID0041983 Clint NA 137.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041983 Fup NA 0.0103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041983 Vd NA 0.2989 L/kg 1compartment NA NA Rat Human +DTXSID0041981 TK.Half.Life NA 2.802 hours 1compartment NA NA Rat Human +DTXSID0041981 Css NA 0.03331 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041981 Css NA 0.2123 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041981 Css NA 0.02252 mg/L PBTK NA 50% Rat Human +DTXSID0041981 Css NA 0.1325 mg/L PBTK NA 95% Rat Human +DTXSID0041983 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041983 Fup 0.0221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041983 Vd NA 0.5283 L/kg 1compartment NA NA Human Human +DTXSID0041983 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0041983 TK.Half.Life NA 13.14 hours 1compartment NA NA Human Human +DTXSID0041983 Css NA 4.366 mg/L 3compartmentss NA 50% Human Human +DTXSID0041983 Css NA 36.49 mg/L 3compartmentss NA 95% Human Human +DTXSID0041983 Css NA 2.626 mg/L PBTK NA 50% Human Human +DTXSID0041983 Css NA 21.8 mg/L PBTK NA 95% Human Human +DTXSID0041983 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041983 Fup 0.0221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041983 Vd NA 0.4112 L/kg 1compartment NA NA Rat Human DTXSID0041983 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041983 TK.Half.Life NA 0.6371 hours 1compartment NA NA Rat Human -DTXSID0041983 Css NA 0.2796 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041983 Css NA 2.502 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041983 Css NA 0.1535 mg/L PBTK NA 50% Rat Human -DTXSID0041983 Css NA 1.359 mg/L PBTK NA 95% Rat Human -DTXSID0041985 Clint NA 100.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041985 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041985 Vd NA 0.4161 L/kg 1compartment NA NA Human Human -DTXSID0041985 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0041985 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human -DTXSID0041985 Css NA 2.649 mg/L 3compartmentss NA 50% Human Human -DTXSID0041985 Css NA 22.86 mg/L 3compartmentss NA 95% Human Human -DTXSID0041985 Css NA 1.548 mg/L PBTK NA 50% Human Human -DTXSID0041985 Css NA 13.43 mg/L PBTK NA 95% Human Human -DTXSID0041985 Clint NA 100.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041985 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041985 Vd NA 0.3181 L/kg 1compartment NA NA Rat Human -DTXSID0041985 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041985 TK.Half.Life NA 3.075 hours 1compartment NA NA Rat Human -DTXSID0041985 Css NA 1.54 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041985 Css NA 10.19 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041985 Css NA 0.8414 mg/L PBTK NA 50% Rat Human -DTXSID0041985 Css NA 5.546 mg/L PBTK NA 95% Rat Human -DTXSID0041987 Clint NA 15.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041987 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0041987 Vd NA 1.345 L/kg 1compartment NA NA Human Human -DTXSID0041987 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0041987 TK.Half.Life NA 15.89 hours 1compartment NA NA Human Human -DTXSID0041987 Css NA 1.934 mg/L 3compartmentss NA 50% Human Human -DTXSID0041987 Css NA 16.78 mg/L 3compartmentss NA 95% Human Human -DTXSID0041987 Css NA 1.194 mg/L PBTK NA 50% Human Human -DTXSID0041987 Css NA 10.11 mg/L PBTK NA 95% Human Human -DTXSID0041987 Clint NA 15.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041987 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0041987 Vd NA 0.9989 L/kg 1compartment NA NA Rat Human +DTXSID0041983 TK.Half.Life NA 6.33 hours 1compartment NA NA Rat Human +DTXSID0041983 Css NA 0.5368 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041983 Css NA 3.569 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041983 Css NA 0.3122 mg/L PBTK NA 50% Rat Human +DTXSID0041983 Css NA 2.015 mg/L PBTK NA 95% Rat Human +DTXSID0041985 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041985 Fup 0.0126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041985 Vd NA 2.867 L/kg 1compartment NA NA Human Human +DTXSID0041985 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID0041985 TK.Half.Life NA 57.1 hours 1compartment NA NA Human Human +DTXSID0041985 Css NA 2.601 mg/L 3compartmentss NA 50% Human Human +DTXSID0041985 Css NA 17.45 mg/L 3compartmentss NA 95% Human Human +DTXSID0041985 Css NA 1.758 mg/L PBTK NA 50% Human Human +DTXSID0041985 Css NA 11.25 mg/L PBTK NA 95% Human Human +DTXSID0041985 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041985 Fup 0.0126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041985 Vd NA 2.144 L/kg 1compartment NA NA Rat Human +DTXSID0041985 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0041985 TK.Half.Life NA 10.43 hours 1compartment NA NA Rat Human +DTXSID0041985 Css NA 0.3368 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041985 Css NA 2.047 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041985 Css NA 0.2247 mg/L PBTK NA 50% Rat Human +DTXSID0041985 Css NA 1.321 mg/L PBTK NA 95% Rat Human +DTXSID0041987 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041987 Fup 0.0364 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0041987 Vd NA 1.727 L/kg 1compartment NA NA Human Human +DTXSID0041987 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0041987 TK.Half.Life NA 10.79 hours 1compartment NA NA Human Human +DTXSID0041987 Css NA 0.8948 mg/L 3compartmentss NA 50% Human Human +DTXSID0041987 Css NA 7.168 mg/L 3compartmentss NA 95% Human Human +DTXSID0041987 Css NA 0.5742 mg/L PBTK NA 50% Human Human +DTXSID0041987 Css NA 4.382 mg/L PBTK NA 95% Human Human +DTXSID0041987 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041987 Fup 0.0364 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0041987 Vd NA 1.289 L/kg 1compartment NA NA Rat Human DTXSID0041987 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0041987 TK.Half.Life NA 6.388 hours 1compartment NA NA Rat Human -DTXSID0041987 Css NA 1.079 mg/L 3compartmentss NA 50% Rat Human -DTXSID0041987 Css NA 7.461 mg/L 3compartmentss NA 95% Rat Human -DTXSID0041987 Css NA 0.6294 mg/L PBTK NA 50% Rat Human -DTXSID0041987 Css NA 4.155 mg/L PBTK NA 95% Rat Human -DTXSID0042080 Clint NA 154.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042080 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042080 Vd NA 1.665 L/kg 1compartment NA NA Human Human -DTXSID0042080 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042080 TK.Half.Life NA 4.058 hours 1compartment NA NA Human Human -DTXSID0042080 Css NA 0.2734 mg/L 3compartmentss NA 50% Human Human -DTXSID0042080 Css NA 2.298 mg/L 3compartmentss NA 95% Human Human -DTXSID0042080 Css NA 0.1716 mg/L PBTK NA 50% Human Human -DTXSID0042080 Css NA 1.381 mg/L PBTK NA 95% Human Human -DTXSID0042080 Clint NA 154.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042080 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042080 Vd NA 1.233 L/kg 1compartment NA NA Rat Human -DTXSID0042080 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042080 TK.Half.Life NA 1.443 hours 1compartment NA NA Rat Human -DTXSID0042080 Css NA 0.1531 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042080 Css NA 1.138 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042080 Css NA 0.09052 mg/L PBTK NA 50% Rat Human -DTXSID0042080 Css NA 0.638 mg/L PBTK NA 95% Rat Human -DTXSID0042084 Clint NA 121.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042084 Fup NA 0.083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042084 Vd NA 2.461 L/kg 1compartment NA NA Human Human +DTXSID0041987 TK.Half.Life NA 3.872 hours 1compartment NA NA Rat Human +DTXSID0041987 Css NA 0.119 mg/L 3compartmentss NA 50% Rat Human +DTXSID0041987 Css NA 0.6937 mg/L 3compartmentss NA 95% Rat Human +DTXSID0041987 Css NA 0.07413 mg/L PBTK NA 50% Rat Human +DTXSID0041987 Css NA 0.4193 mg/L PBTK NA 95% Rat Human +DTXSID0042080 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042080 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042080 Vd NA 1.687 L/kg 1compartment NA NA Human Human +DTXSID0042080 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0042080 TK.Half.Life NA 19.37 hours 1compartment NA NA Human Human +DTXSID0042080 Css NA 1.782 mg/L 3compartmentss NA 50% Human Human +DTXSID0042080 Css NA 15.79 mg/L 3compartmentss NA 95% Human Human +DTXSID0042080 Css NA 1.125 mg/L PBTK NA 50% Human Human +DTXSID0042080 Css NA 9.382 mg/L PBTK NA 95% Human Human +DTXSID0042080 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042080 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042080 Vd NA 1.25 L/kg 1compartment NA NA Rat Human +DTXSID0042080 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0042080 TK.Half.Life NA 7.016 hours 1compartment NA NA Rat Human +DTXSID0042080 Css NA 0.2299 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042080 Css NA 1.635 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042080 Css NA 0.1406 mg/L PBTK NA 50% Rat Human +DTXSID0042080 Css NA 0.9574 mg/L PBTK NA 95% Rat Human +DTXSID0042084 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042084 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042084 Vd NA 2.451 L/kg 1compartment NA NA Human Human DTXSID0042084 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042084 TK.Half.Life NA 2.629 hours 1compartment NA NA Human Human -DTXSID0042084 Css NA 0.04944 mg/L 3compartmentss NA 50% Human Human -DTXSID0042084 Css NA 0.4146 mg/L 3compartmentss NA 95% Human Human -DTXSID0042084 Css NA 0.03767 mg/L PBTK NA 50% Human Human -DTXSID0042084 Css NA 0.2903 mg/L PBTK NA 95% Human Human -DTXSID0042084 Clint NA 121.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042084 Fup NA 0.083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042084 Vd NA 2.149 L/kg 1compartment NA NA Rat Human +DTXSID0042084 TK.Half.Life NA 4.636 hours 1compartment NA NA Human Human +DTXSID0042084 Css NA 0.1243 mg/L 3compartmentss NA 50% Human Human +DTXSID0042084 Css NA 0.8896 mg/L 3compartmentss NA 95% Human Human +DTXSID0042084 Css NA 0.1236 mg/L PBTK NA 50% Human Human +DTXSID0042084 Css NA 0.7087 mg/L PBTK NA 95% Human Human +DTXSID0042084 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042084 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042084 Vd NA 2.459 L/kg 1compartment NA NA Rat Human DTXSID0042084 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042084 TK.Half.Life NA 1.07 hours 1compartment NA NA Rat Human -DTXSID0042084 Css NA 0.02784 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042084 Css NA 0.1917 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042084 Css NA 0.02026 mg/L PBTK NA 50% Rat Human -DTXSID0042084 Css NA 0.1258 mg/L PBTK NA 95% Rat Human -DTXSID0042086 Clint 9.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0042086 Fup 0.00275 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0042086 Vd NA 3.598 L/kg 1compartment NA NA Human Human -DTXSID0042086 Days.Css NA 51 Days PBTK NA NA Human Human -DTXSID0042086 TK.Half.Life NA 246.4 hours 1compartment NA NA Human Human -DTXSID0042086 Css NA 7.748 mg/L 3compartmentss NA 50% Human Human -DTXSID0042086 Css NA 44.11 mg/L 3compartmentss NA 95% Human Human -DTXSID0042086 Css NA 5.612 mg/L PBTK NA 50% Human Human -DTXSID0042086 Css NA 31.48 mg/L PBTK NA 95% Human Human -DTXSID0042086 Clint 9.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0042086 Fup 0.00275 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0042086 Vd NA 2.71 L/kg 1compartment NA NA Rat Human -DTXSID0042086 Days.Css NA 28 Days PBTK NA NA Rat Human -DTXSID0042086 TK.Half.Life NA 36.33 hours 1compartment NA NA Rat Human -DTXSID0042086 Css NA 4.434 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042086 Css NA 18.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042086 Css NA 3.052 mg/L PBTK NA 50% Rat Human -DTXSID0042086 Css NA 13.08 mg/L PBTK NA 95% Rat Human -DTXSID0042117 Clint NA 241.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042117 Fup NA 0.093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042117 Vd NA 1.094 L/kg 1compartment NA NA Human Human +DTXSID0042084 TK.Half.Life NA 2.645 hours 1compartment NA NA Rat Human +DTXSID0042084 Css NA 0.01391 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042084 Css NA 0.08125 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042084 Css NA 0.01435 mg/L PBTK NA 50% Rat Human +DTXSID0042084 Css NA 0.06218 mg/L PBTK NA 95% Rat Human +DTXSID0042117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042117 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042117 Vd NA 2.243 L/kg 1compartment NA NA Human Human DTXSID0042117 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042117 TK.Half.Life NA 1.136 hours 1compartment NA NA Human Human -DTXSID0042117 Css NA 0.03 mg/L 3compartmentss NA 50% Human Human -DTXSID0042117 Css NA 0.2464 mg/L 3compartmentss NA 95% Human Human -DTXSID0042117 Css NA 0.0193 mg/L PBTK NA 50% Human Human -DTXSID0042117 Css NA 0.1538 mg/L PBTK NA 95% Human Human -DTXSID0042117 Clint NA 241.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042117 Fup NA 0.093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042117 Vd NA 0.8514 L/kg 1compartment NA NA Rat Human +DTXSID0042117 TK.Half.Life NA 5.514 hours 1compartment NA NA Human Human +DTXSID0042117 Css NA 0.2053 mg/L 3compartmentss NA 50% Human Human +DTXSID0042117 Css NA 1.287 mg/L 3compartmentss NA 95% Human Human +DTXSID0042117 Css NA 0.1468 mg/L PBTK NA 50% Human Human +DTXSID0042117 Css NA 0.8768 mg/L PBTK NA 95% Human Human +DTXSID0042117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042117 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042117 Vd NA 1.714 L/kg 1compartment NA NA Rat Human DTXSID0042117 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042117 TK.Half.Life NA 0.4126 hours 1compartment NA NA Rat Human -DTXSID0042117 Css NA 0.01719 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042117 Css NA 0.1156 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042117 Css NA 0.01046 mg/L PBTK NA 50% Rat Human -DTXSID0042117 Css NA 0.0668 mg/L PBTK NA 95% Rat Human -DTXSID0042167 Clint NA 0.07389 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042167 Fup NA 0.2213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042167 Vd NA 0.4081 L/kg 1compartment NA NA Human Human +DTXSID0042117 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human +DTXSID0042117 Css NA 0.02583 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042117 Css NA 0.1273 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042117 Css NA 0.01842 mg/L PBTK NA 50% Rat Human +DTXSID0042117 Css NA 0.08732 mg/L PBTK NA 95% Rat Human +DTXSID0042167 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042167 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042167 Vd NA 0.4955 L/kg 1compartment NA NA Human Human DTXSID0042167 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0042167 TK.Half.Life NA 10.6 hours 1compartment NA NA Human Human -DTXSID0042167 Css NA 3.087 mg/L 3compartmentss NA 50% Human Human -DTXSID0042167 Css NA 11.87 mg/L 3compartmentss NA 95% Human Human -DTXSID0042167 Css NA 2.086 mg/L PBTK NA 50% Human Human -DTXSID0042167 Css NA 7.27 mg/L PBTK NA 95% Human Human -DTXSID0042167 Clint NA 0.07389 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042167 Fup NA 0.2213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042167 Vd NA 0.413 L/kg 1compartment NA NA Rat Human +DTXSID0042167 TK.Half.Life NA 9.774 hours 1compartment NA NA Human Human +DTXSID0042167 Css NA 1.198 mg/L 3compartmentss NA 50% Human Human +DTXSID0042167 Css NA 5.294 mg/L 3compartmentss NA 95% Human Human +DTXSID0042167 Css NA 0.8653 mg/L PBTK NA 50% Human Human +DTXSID0042167 Css NA 3.325 mg/L PBTK NA 95% Human Human +DTXSID0042167 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042167 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042167 Vd NA 0.5037 L/kg 1compartment NA NA Rat Human DTXSID0042167 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042167 TK.Half.Life NA 3.879 hours 1compartment NA NA Rat Human -DTXSID0042167 Css NA 0.9224 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042167 Css NA 2.949 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042167 Css NA 0.5906 mg/L PBTK NA 50% Rat Human -DTXSID0042167 Css NA 1.693 mg/L PBTK NA 95% Rat Human +DTXSID0042167 TK.Half.Life NA 3.386 hours 1compartment NA NA Rat Human +DTXSID0042167 Css NA 0.006413 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042167 Css NA 0.02927 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042167 Css NA 0.004436 mg/L PBTK NA 50% Rat Human +DTXSID0042167 Css NA 0.01776 mg/L PBTK NA 95% Rat Human DTXSID0042169 Clint 18.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0042169 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042169 Vd NA 0.3192 L/kg 1compartment NA NA Human Human +DTXSID0042169 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042169 Vd NA 0.3196 L/kg 1compartment NA NA Human Human DTXSID0042169 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042169 TK.Half.Life NA 1.263 hours 1compartment NA NA Human Human -DTXSID0042169 Css NA 0.5502 mg/L 3compartmentss NA 50% Human Human -DTXSID0042169 Css NA 4.142 mg/L 3compartmentss NA 95% Human Human -DTXSID0042169 Css NA 0.3383 mg/L PBTK NA 50% Human Human -DTXSID0042169 Css NA 2.468 mg/L PBTK NA 95% Human Human +DTXSID0042169 TK.Half.Life NA 0.657 hours 1compartment NA NA Human Human +DTXSID0042169 Css NA 0.1731 mg/L 3compartmentss NA 50% Human Human +DTXSID0042169 Css NA 1.247 mg/L 3compartmentss NA 95% Human Human +DTXSID0042169 Css NA 0.11 mg/L PBTK NA 50% Human Human +DTXSID0042169 Css NA 0.765 mg/L PBTK NA 95% Human Human DTXSID0042169 Clint 18.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0042169 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042169 Vd NA 0.2964 L/kg 1compartment NA NA Rat Human +DTXSID0042169 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042169 Vd NA 0.3148 L/kg 1compartment NA NA Rat Human DTXSID0042169 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042169 TK.Half.Life NA 0.7265 hours 1compartment NA NA Rat Human -DTXSID0042169 Css NA 0.3084 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042169 Css NA 1.731 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042169 Css NA 0.1774 mg/L PBTK NA 50% Rat Human -DTXSID0042169 Css NA 0.9671 mg/L PBTK NA 95% Rat Human -DTXSID0042242 Clint NA 1.964 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042242 Fup NA 0.4438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042242 Vd NA 1.371 L/kg 1compartment NA NA Human Human +DTXSID0042169 TK.Half.Life NA 0.3699 hours 1compartment NA NA Rat Human +DTXSID0042169 Css NA 0.02234 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042169 Css NA 0.1214 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042169 Css NA 0.01392 mg/L PBTK NA 50% Rat Human +DTXSID0042169 Css NA 0.07272 mg/L PBTK NA 95% Rat Human +DTXSID0042242 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042242 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042242 Vd NA 1.141 L/kg 1compartment NA NA Human Human DTXSID0042242 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042242 TK.Half.Life NA 5.869 hours 1compartment NA NA Human Human -DTXSID0042242 Css NA 0.4142 mg/L 3compartmentss NA 50% Human Human -DTXSID0042242 Css NA 2.293 mg/L 3compartmentss NA 95% Human Human -DTXSID0042242 Css NA 0.3374 mg/L PBTK NA 50% Human Human -DTXSID0042242 Css NA 1.575 mg/L PBTK NA 95% Human Human -DTXSID0042242 Clint NA 1.964 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042242 Fup NA 0.4438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042242 Vd NA 1.162 L/kg 1compartment NA NA Rat Human +DTXSID0042242 TK.Half.Life NA 1.462 hours 1compartment NA NA Human Human +DTXSID0042242 Css NA 0.06592 mg/L 3compartmentss NA 50% Human Human +DTXSID0042242 Css NA 0.5142 mg/L 3compartmentss NA 95% Human Human +DTXSID0042242 Css NA 0.04929 mg/L PBTK NA 50% Human Human +DTXSID0042242 Css NA 0.3504 mg/L PBTK NA 95% Human Human +DTXSID0042242 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042242 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042242 Vd NA 0.9638 L/kg 1compartment NA NA Rat Human DTXSID0042242 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042242 TK.Half.Life NA 2.393 hours 1compartment NA NA Rat Human -DTXSID0042242 Css NA 0.1822 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042242 Css NA 0.8239 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042242 Css NA 0.1442 mg/L PBTK NA 50% Rat Human -DTXSID0042242 Css NA 0.5163 mg/L PBTK NA 95% Rat Human -DTXSID0042244 Clint NA 21.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042244 Fup NA 0.0258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042244 Vd NA 1.315 L/kg 1compartment NA NA Human Human +DTXSID0042242 TK.Half.Life NA 0.6301 hours 1compartment NA NA Rat Human +DTXSID0042242 Css NA 0.008218 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042242 Css NA 0.04865 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042242 Css NA 0.006194 mg/L PBTK NA 50% Rat Human +DTXSID0042242 Css NA 0.03333 mg/L PBTK NA 95% Rat Human +DTXSID0042244 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042244 Fup 0.0405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042244 Vd NA 1.955 L/kg 1compartment NA NA Human Human DTXSID0042244 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042244 TK.Half.Life NA 9.783 hours 1compartment NA NA Human Human -DTXSID0042244 Css NA 1.164 mg/L 3compartmentss NA 50% Human Human -DTXSID0042244 Css NA 10.12 mg/L 3compartmentss NA 95% Human Human -DTXSID0042244 Css NA 0.7273 mg/L PBTK NA 50% Human Human -DTXSID0042244 Css NA 6.009 mg/L PBTK NA 95% Human Human -DTXSID0042244 Clint NA 21.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042244 Fup NA 0.0258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042244 Vd NA 0.9784 L/kg 1compartment NA NA Rat Human +DTXSID0042244 TK.Half.Life NA 12.15 hours 1compartment NA NA Human Human +DTXSID0042244 Css NA 0.8662 mg/L 3compartmentss NA 50% Human Human +DTXSID0042244 Css NA 6.838 mg/L 3compartmentss NA 95% Human Human +DTXSID0042244 Css NA 0.5623 mg/L PBTK NA 50% Human Human +DTXSID0042244 Css NA 4.191 mg/L PBTK NA 95% Human Human +DTXSID0042244 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042244 Fup 0.0405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042244 Vd NA 1.461 L/kg 1compartment NA NA Rat Human DTXSID0042244 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042244 TK.Half.Life NA 3.963 hours 1compartment NA NA Rat Human -DTXSID0042244 Css NA 0.6532 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042244 Css NA 4.744 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042244 Css NA 0.3814 mg/L PBTK NA 50% Rat Human -DTXSID0042244 Css NA 2.657 mg/L PBTK NA 95% Rat Human -DTXSID0042248 Clint NA 108.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042248 Fup NA 0.0395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042248 Vd NA 1.063 L/kg 1compartment NA NA Human Human +DTXSID0042244 TK.Half.Life NA 4.011 hours 1compartment NA NA Rat Human +DTXSID0042244 Css NA 0.1108 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042244 Css NA 0.7147 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042244 Css NA 0.07022 mg/L PBTK NA 50% Rat Human +DTXSID0042244 Css NA 0.4328 mg/L PBTK NA 95% Rat Human +DTXSID0042248 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042248 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042248 Vd NA 1.161 L/kg 1compartment NA NA Human Human DTXSID0042248 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042248 TK.Half.Life NA 1.899 hours 1compartment NA NA Human Human -DTXSID0042248 Css NA 0.1607 mg/L 3compartmentss NA 50% Human Human -DTXSID0042248 Css NA 1.527 mg/L 3compartmentss NA 95% Human Human -DTXSID0042248 Css NA 0.1001 mg/L PBTK NA 50% Human Human -DTXSID0042248 Css NA 0.9292 mg/L PBTK NA 95% Human Human -DTXSID0042248 Clint NA 108.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042248 Fup NA 0.0395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042248 Vd NA 0.8035 L/kg 1compartment NA NA Rat Human +DTXSID0042248 TK.Half.Life NA 2.103 hours 1compartment NA NA Human Human +DTXSID0042248 Css NA 0.1297 mg/L 3compartmentss NA 50% Human Human +DTXSID0042248 Css NA 0.9348 mg/L 3compartmentss NA 95% Human Human +DTXSID0042248 Css NA 0.0899 mg/L PBTK NA 50% Human Human +DTXSID0042248 Css NA 0.622 mg/L PBTK NA 95% Human Human +DTXSID0042248 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042248 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042248 Vd NA 0.9339 L/kg 1compartment NA NA Rat Human DTXSID0042248 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042248 TK.Half.Life NA 0.7506 hours 1compartment NA NA Rat Human -DTXSID0042248 Css NA 0.09238 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042248 Css NA 0.7252 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042248 Css NA 0.05384 mg/L PBTK NA 50% Rat Human -DTXSID0042248 Css NA 0.4119 mg/L PBTK NA 95% Rat Human -DTXSID0042325 Clint NA 44.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042325 Fup NA 0.1415 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042325 Vd NA 2.098 L/kg 1compartment NA NA Human Human -DTXSID0042325 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042325 TK.Half.Life NA 3.635 hours 1compartment NA NA Human Human -DTXSID0042325 Css NA 0.1314 mg/L 3compartmentss NA 50% Human Human -DTXSID0042325 Css NA 0.9598 mg/L 3compartmentss NA 95% Human Human -DTXSID0042325 Css NA 0.09129 mg/L PBTK NA 50% Human Human -DTXSID0042325 Css NA 0.6389 mg/L PBTK NA 95% Human Human -DTXSID0042325 Clint NA 44.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042325 Fup NA 0.1415 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042325 Vd NA 1.598 L/kg 1compartment NA NA Rat Human -DTXSID0042325 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042325 TK.Half.Life NA 1.191 hours 1compartment NA NA Rat Human -DTXSID0042325 Css NA 0.07426 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042325 Css NA 0.4349 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042325 Css NA 0.04918 mg/L PBTK NA 50% Rat Human -DTXSID0042325 Css NA 0.2761 mg/L PBTK NA 95% Rat Human -DTXSID0042327 Clint NA 1.141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042327 Fup NA 0.7157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042327 Vd NA 0.9781 L/kg 1compartment NA NA Human Human -DTXSID0042327 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042327 TK.Half.Life NA 3.375 hours 1compartment NA NA Human Human -DTXSID0042327 Css NA 0.3646 mg/L 3compartmentss NA 50% Human Human -DTXSID0042327 Css NA 2.529 mg/L 3compartmentss NA 95% Human Human -DTXSID0042327 Css NA 0.3104 mg/L PBTK NA 50% Human Human -DTXSID0042327 Css NA 1.679 mg/L PBTK NA 95% Human Human -DTXSID0042327 Clint NA 1.141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042327 Fup NA 0.7157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042327 Vd NA 0.942 L/kg 1compartment NA NA Rat Human -DTXSID0042327 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042327 TK.Half.Life NA 1.573 hours 1compartment NA NA Rat Human -DTXSID0042327 Css NA 0.1388 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042327 Css NA 0.945 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042327 Css NA 0.1168 mg/L PBTK NA 50% Rat Human -DTXSID0042327 Css NA 0.5683 mg/L PBTK NA 95% Rat Human -DTXSID0042400 Clint NA 1.519 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042400 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042400 Vd NA 1.069 L/kg 1compartment NA NA Human Human -DTXSID0042400 Days.Css NA 36 Days PBTK NA NA Human Human -DTXSID0042400 TK.Half.Life NA 165.3 hours 1compartment NA NA Human Human -DTXSID0042400 Css NA 26.76 mg/L 3compartmentss NA 50% Human Human -DTXSID0042400 Css NA 187.2 mg/L 3compartmentss NA 95% Human Human -DTXSID0042400 Css NA 16.35 mg/L PBTK NA 50% Human Human -DTXSID0042400 Css NA 108.7 mg/L PBTK NA 95% Human Human -DTXSID0042400 Clint NA 1.519 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042400 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042400 Vd NA 0.7917 L/kg 1compartment NA NA Rat Human -DTXSID0042400 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID0042400 TK.Half.Life NA 60.91 hours 1compartment NA NA Rat Human -DTXSID0042400 Css NA 12.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042400 Css NA 71.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042400 Css NA 7.154 mg/L PBTK NA 50% Rat Human -DTXSID0042400 Css NA 38.93 mg/L PBTK NA 95% Rat Human +DTXSID0042248 TK.Half.Life NA 0.8893 hours 1compartment NA NA Rat Human +DTXSID0042248 Css NA 0.01656 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042248 Css NA 0.08891 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042248 Css NA 0.0114 mg/L PBTK NA 50% Rat Human +DTXSID0042248 Css NA 0.05876 mg/L PBTK NA 95% Rat Human +DTXSID0042400 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042400 Fup 0.0897 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042400 Vd NA 0.7871 L/kg 1compartment NA NA Human Human +DTXSID0042400 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0042400 TK.Half.Life NA 2.189 hours 1compartment NA NA Human Human +DTXSID0042400 Css NA 0.3118 mg/L 3compartmentss NA 50% Human Human +DTXSID0042400 Css NA 2.496 mg/L 3compartmentss NA 95% Human Human +DTXSID0042400 Css NA 0.1993 mg/L PBTK NA 50% Human Human +DTXSID0042400 Css NA 1.501 mg/L PBTK NA 95% Human Human +DTXSID0042400 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042400 Fup 0.0897 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042400 Vd NA 0.6414 L/kg 1compartment NA NA Rat Human +DTXSID0042400 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0042400 TK.Half.Life NA 1.031 hours 1compartment NA NA Rat Human +DTXSID0042400 Css NA 0.0409 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042400 Css NA 0.2542 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042400 Css NA 0.02536 mg/L PBTK NA 50% Rat Human +DTXSID0042400 Css NA 0.1498 mg/L PBTK NA 95% Rat Human DTXSID0042406 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0042406 Fup NA 0.5589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042406 Vd NA 0.3901 L/kg 1compartment NA NA Human Human +DTXSID0042406 Vd NA 0.3972 L/kg 1compartment NA NA Human Human DTXSID0042406 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042406 TK.Half.Life NA 4.516 hours 1compartment NA NA Human Human -DTXSID0042406 Css NA 1.474 mg/L 3compartmentss NA 50% Human Human -DTXSID0042406 Css NA 9.595 mg/L 3compartmentss NA 95% Human Human -DTXSID0042406 Css NA 1.038 mg/L PBTK NA 50% Human Human -DTXSID0042406 Css NA 5.84 mg/L PBTK NA 95% Human Human +DTXSID0042406 TK.Half.Life NA 4.6 hours 1compartment NA NA Human Human +DTXSID0042406 Css NA 1.254 mg/L 3compartmentss NA 50% Human Human +DTXSID0042406 Css NA 7.88 mg/L 3compartmentss NA 95% Human Human +DTXSID0042406 Css NA 0.8844 mg/L PBTK NA 50% Human Human +DTXSID0042406 Css NA 4.769 mg/L PBTK NA 95% Human Human DTXSID0042406 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0042406 Fup NA 0.5589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042406 Vd NA 0.405 L/kg 1compartment NA NA Rat Human +DTXSID0042406 Vd NA 0.4111 L/kg 1compartment NA NA Rat Human DTXSID0042406 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042406 TK.Half.Life NA 1.598 hours 1compartment NA NA Rat Human -DTXSID0042406 Css NA 0.3914 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042406 Css NA 2.299 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042406 Css NA 0.2622 mg/L PBTK NA 50% Rat Human -DTXSID0042406 Css NA 1.302 mg/L PBTK NA 95% Rat Human -DTXSID0042454 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042454 Fup NA 0.0511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042454 Vd NA 3.095 L/kg 1compartment NA NA Human Human -DTXSID0042454 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID0042454 TK.Half.Life NA 16640 hours 1compartment NA NA Human Human -DTXSID0042454 Css NA 618.8 mg/L 3compartmentss NA 50% Human Human -DTXSID0042454 Css NA 1745 mg/L 3compartmentss NA 95% Human Human -DTXSID0042454 Css NA 430.4 mg/L PBTK NA 50% Human Human -DTXSID0042454 Css NA 1142 mg/L PBTK NA 95% Human Human -DTXSID0042454 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042454 Fup NA 0.0511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042454 Vd NA 2.319 L/kg 1compartment NA NA Rat Human -DTXSID0042454 Days.Css NA 1165 Days PBTK NA NA Rat Human -DTXSID0042454 TK.Half.Life NA 1089 hours 1compartment NA NA Rat Human -DTXSID0042454 Css NA 167.7 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042454 Css NA 371.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042454 Css NA 111.7 mg/L PBTK NA 50% Rat Human -DTXSID0042454 Css NA 224.1 mg/L PBTK NA 95% Rat Human -DTXSID0042583 Clint NA 1.949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042583 Fup NA 0.6391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042583 Vd NA 2.378 L/kg 1compartment NA NA Human Human +DTXSID0042406 TK.Half.Life NA 1.622 hours 1compartment NA NA Rat Human +DTXSID0042406 Css NA 0.02411 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042406 Css NA 0.1949 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042406 Css NA 0.01626 mg/L PBTK NA 50% Rat Human +DTXSID0042406 Css NA 0.1172 mg/L PBTK NA 95% Rat Human +DTXSID0042454 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042454 Fup 0.0273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042454 Vd NA 3.099 L/kg 1compartment NA NA Human Human +DTXSID0042454 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID0042454 TK.Half.Life NA 77.38 hours 1compartment NA NA Human Human +DTXSID0042454 Css NA 2.938 mg/L 3compartmentss NA 50% Human Human +DTXSID0042454 Css NA 20.1 mg/L 3compartmentss NA 95% Human Human +DTXSID0042454 Css NA 2.032 mg/L PBTK NA 50% Human Human +DTXSID0042454 Css NA 13.53 mg/L PBTK NA 95% Human Human +DTXSID0042454 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042454 Fup 0.0273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042454 Vd NA 2.322 L/kg 1compartment NA NA Rat Human +DTXSID0042454 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID0042454 TK.Half.Life NA 10.78 hours 1compartment NA NA Rat Human +DTXSID0042454 Css NA 0.3826 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042454 Css NA 2.182 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042454 Css NA 0.2632 mg/L PBTK NA 50% Rat Human +DTXSID0042454 Css NA 1.454 mg/L PBTK NA 95% Rat Human +DTXSID0042583 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042583 Fup 0.673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042583 Vd NA 2.466 L/kg 1compartment NA NA Human Human DTXSID0042583 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042583 TK.Half.Life NA 6.33 hours 1compartment NA NA Human Human -DTXSID0042583 Css NA 0.2157 mg/L 3compartmentss NA 50% Human Human -DTXSID0042583 Css NA 1.986 mg/L 3compartmentss NA 95% Human Human -DTXSID0042583 Css NA 0.2306 mg/L PBTK NA 50% Human Human -DTXSID0042583 Css NA 1.462 mg/L PBTK NA 95% Human Human -DTXSID0042583 Clint NA 1.949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042583 Fup NA 0.6391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042583 Vd NA 2.408 L/kg 1compartment NA NA Rat Human +DTXSID0042583 TK.Half.Life NA 3.027 hours 1compartment NA NA Human Human +DTXSID0042583 Css NA 0.0373 mg/L 3compartmentss NA 50% Human Human +DTXSID0042583 Css NA 0.4477 mg/L 3compartmentss NA 95% Human Human +DTXSID0042583 Css NA 0.04025 mg/L PBTK NA 50% Human Human +DTXSID0042583 Css NA 0.3534 mg/L PBTK NA 95% Human Human +DTXSID0042583 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042583 Fup 0.673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042583 Vd NA 2.498 L/kg 1compartment NA NA Rat Human DTXSID0042583 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042583 TK.Half.Life NA 3.413 hours 1compartment NA NA Rat Human -DTXSID0042583 Css NA 0.08954 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042583 Css NA 0.7599 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042583 Css NA 0.09511 mg/L PBTK NA 50% Rat Human -DTXSID0042583 Css NA 0.4993 mg/L PBTK NA 95% Rat Human -DTXSID0042612 Clint NA 33.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042612 Fup NA 0.0532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042612 Vd NA 1.343 L/kg 1compartment NA NA Human Human +DTXSID0042583 TK.Half.Life NA 1.703 hours 1compartment NA NA Rat Human +DTXSID0042583 Css NA 0.000323 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042583 Css NA 0.003919 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042583 Css NA 0.0003477 mg/L PBTK NA 50% Rat Human +DTXSID0042583 Css NA 0.00283 mg/L PBTK NA 95% Rat Human +DTXSID0042612 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042612 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042612 Vd NA 3 L/kg 1compartment NA NA Human Human DTXSID0042612 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042612 TK.Half.Life NA 3.244 hours 1compartment NA NA Human Human -DTXSID0042612 Css NA 0.2646 mg/L 3compartmentss NA 50% Human Human -DTXSID0042612 Css NA 2.332 mg/L 3compartmentss NA 95% Human Human -DTXSID0042612 Css NA 0.1842 mg/L PBTK NA 50% Human Human -DTXSID0042612 Css NA 1.481 mg/L PBTK NA 95% Human Human -DTXSID0042612 Clint NA 33.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042612 Fup NA 0.0532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042612 Vd NA 1.318 L/kg 1compartment NA NA Rat Human +DTXSID0042612 TK.Half.Life NA 9.482 hours 1compartment NA NA Human Human +DTXSID0042612 Css NA 0.221 mg/L 3compartmentss NA 50% Human Human +DTXSID0042612 Css NA 1.591 mg/L 3compartmentss NA 95% Human Human +DTXSID0042612 Css NA 0.224 mg/L PBTK NA 50% Human Human +DTXSID0042612 Css NA 1.365 mg/L PBTK NA 95% Human Human +DTXSID0042612 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042612 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042612 Vd NA 3.003 L/kg 1compartment NA NA Rat Human DTXSID0042612 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042612 TK.Half.Life NA 1.92 hours 1compartment NA NA Rat Human -DTXSID0042612 Css NA 0.1479 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042612 Css NA 1.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042612 Css NA 0.09776 mg/L PBTK NA 50% Rat Human -DTXSID0042612 Css NA 0.6457 mg/L PBTK NA 95% Rat Human -DTXSID0042614 Clint NA 17.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042614 Fup NA 0.1114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042614 Vd NA 2.62 L/kg 1compartment NA NA Human Human +DTXSID0042612 TK.Half.Life NA 5.626 hours 1compartment NA NA Rat Human +DTXSID0042612 Css NA 0.026 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042612 Css NA 0.1399 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042612 Css NA 0.02739 mg/L PBTK NA 50% Rat Human +DTXSID0042612 Css NA 0.1137 mg/L PBTK NA 95% Rat Human +DTXSID0042614 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042614 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042614 Vd NA 3.718 L/kg 1compartment NA NA Human Human DTXSID0042614 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042614 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human -DTXSID0042614 Css NA 0.1982 mg/L 3compartmentss NA 50% Human Human -DTXSID0042614 Css NA 1.696 mg/L 3compartmentss NA 95% Human Human -DTXSID0042614 Css NA 0.1676 mg/L PBTK NA 50% Human Human -DTXSID0042614 Css NA 1.219 mg/L PBTK NA 95% Human Human -DTXSID0042614 Clint NA 17.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042614 Fup NA 0.1114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042614 Vd NA 2.479 L/kg 1compartment NA NA Rat Human +DTXSID0042614 TK.Half.Life NA 11.62 hours 1compartment NA NA Human Human +DTXSID0042614 Css NA 0.215 mg/L 3compartmentss NA 50% Human Human +DTXSID0042614 Css NA 1.392 mg/L 3compartmentss NA 95% Human Human +DTXSID0042614 Css NA 0.2258 mg/L PBTK NA 50% Human Human +DTXSID0042614 Css NA 1.242 mg/L PBTK NA 95% Human Human +DTXSID0042614 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042614 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042614 Vd NA 3.546 L/kg 1compartment NA NA Rat Human DTXSID0042614 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042614 TK.Half.Life NA 3.011 hours 1compartment NA NA Rat Human -DTXSID0042614 Css NA 0.1086 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042614 Css NA 0.7321 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042614 Css NA 0.08849 mg/L PBTK NA 50% Rat Human -DTXSID0042614 Css NA 0.4926 mg/L PBTK NA 95% Rat Human -DTXSID0042618 Clint NA 20.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042618 Fup NA 0.232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0042618 Vd NA 3.513 L/kg 1compartment NA NA Human Human +DTXSID0042614 TK.Half.Life NA 5.501 hours 1compartment NA NA Rat Human +DTXSID0042614 Css NA 0.02512 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042614 Css NA 0.1251 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042614 Css NA 0.02746 mg/L PBTK NA 50% Rat Human +DTXSID0042614 Css NA 0.1116 mg/L PBTK NA 95% Rat Human +DTXSID0042618 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042618 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0042618 Vd NA 2.427 L/kg 1compartment NA NA Human Human DTXSID0042618 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042618 TK.Half.Life NA 3.673 hours 1compartment NA NA Human Human -DTXSID0042618 Css NA 0.04651 mg/L 3compartmentss NA 50% Human Human -DTXSID0042618 Css NA 0.3652 mg/L 3compartmentss NA 95% Human Human -DTXSID0042618 Css NA 0.05446 mg/L PBTK NA 50% Human Human -DTXSID0042618 Css NA 0.3402 mg/L PBTK NA 95% Human Human -DTXSID0042618 Clint NA 20.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042618 Fup NA 0.232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0042618 Vd NA 3.546 L/kg 1compartment NA NA Rat Human +DTXSID0042618 TK.Half.Life NA 5.2 hours 1compartment NA NA Human Human +DTXSID0042618 Css NA 0.1367 mg/L 3compartmentss NA 50% Human Human +DTXSID0042618 Css NA 1.004 mg/L 3compartmentss NA 95% Human Human +DTXSID0042618 Css NA 0.1441 mg/L PBTK NA 50% Human Human +DTXSID0042618 Css NA 0.8512 mg/L PBTK NA 95% Human Human +DTXSID0042618 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042618 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0042618 Vd NA 2.407 L/kg 1compartment NA NA Rat Human DTXSID0042618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042618 TK.Half.Life NA 2.104 hours 1compartment NA NA Rat Human -DTXSID0042618 Css NA 0.0242 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042618 Css NA 0.1601 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042618 Css NA 0.02855 mg/L PBTK NA 50% Rat Human -DTXSID0042618 Css NA 0.1477 mg/L PBTK NA 95% Rat Human +DTXSID0042618 TK.Half.Life NA 3.056 hours 1compartment NA NA Rat Human +DTXSID0042618 Css NA 0.01563 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042618 Css NA 0.08765 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042618 Css NA 0.01702 mg/L PBTK NA 50% Rat Human +DTXSID0042618 Css NA 0.07152 mg/L PBTK NA 95% Rat Human DTXSID0042668 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0042668 Fup 0.78 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0042668 Vd NA 0.4583 L/kg 1compartment NA NA Human Human +DTXSID0042668 Vd NA 0.4126 L/kg 1compartment NA NA Human Human DTXSID0042668 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0042668 TK.Half.Life NA 3.802 hours 1compartment NA NA Human Human -DTXSID0042668 Css NA 1.128 mg/L 3compartmentss NA 50% Human Human -DTXSID0042668 Css NA 6.531 mg/L 3compartmentss NA 95% Human Human -DTXSID0042668 Css NA 0.829 mg/L PBTK NA 50% Human Human -DTXSID0042668 Css NA 4.014 mg/L PBTK NA 95% Human Human +DTXSID0042668 TK.Half.Life NA 3.423 hours 1compartment NA NA Human Human +DTXSID0042668 Css NA 0.9843 mg/L 3compartmentss NA 50% Human Human +DTXSID0042668 Css NA 5.672 mg/L 3compartmentss NA 95% Human Human +DTXSID0042668 Css NA 0.7068 mg/L PBTK NA 50% Human Human +DTXSID0042668 Css NA 3.469 mg/L PBTK NA 95% Human Human DTXSID0042668 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0042668 Fup 0.78 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0042668 Vd NA 0.4826 L/kg 1compartment NA NA Rat Human +DTXSID0042668 Vd NA 0.445 L/kg 1compartment NA NA Rat Human DTXSID0042668 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0042668 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Human -DTXSID0042668 Css NA 0.2938 mg/L 3compartmentss NA 50% Rat Human -DTXSID0042668 Css NA 1.624 mg/L 3compartmentss NA 95% Rat Human -DTXSID0042668 Css NA 0.2064 mg/L PBTK NA 50% Rat Human -DTXSID0042668 Css NA 0.9353 mg/L PBTK NA 95% Rat Human -DTXSID0043761 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043761 Fup NA 0.0492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043761 Vd NA 2.017 L/kg 1compartment NA NA Human Human -DTXSID0043761 Days.Css NA 124 Days PBTK NA NA Human Human -DTXSID0043761 TK.Half.Life NA 515.4 hours 1compartment NA NA Human Human -DTXSID0043761 Css NA 36.32 mg/L 3compartmentss NA 50% Human Human -DTXSID0043761 Css NA 141.3 mg/L 3compartmentss NA 95% Human Human -DTXSID0043761 Css NA 23.84 mg/L PBTK NA 50% Human Human -DTXSID0043761 Css NA 87.01 mg/L PBTK NA 95% Human Human -DTXSID0043761 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043761 Fup NA 0.0492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043761 Vd NA 1.51 L/kg 1compartment NA NA Rat Human -DTXSID0043761 Days.Css NA 29 Days PBTK NA NA Rat Human -DTXSID0043761 TK.Half.Life NA 82.87 hours 1compartment NA NA Rat Human -DTXSID0043761 Css NA 10.06 mg/L 3compartmentss NA 50% Rat Human -DTXSID0043761 Css NA 32.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID0043761 Css NA 6.237 mg/L PBTK NA 50% Rat Human -DTXSID0043761 Css NA 18.64 mg/L PBTK NA 95% Rat Human -DTXSID0043763 Clint NA 3.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043763 Fup NA 0.9811 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043763 Vd NA 0.7809 L/kg 1compartment NA NA Human Human +DTXSID0042668 TK.Half.Life NA 1.258 hours 1compartment NA NA Rat Human +DTXSID0042668 Css NA 0.01815 mg/L 3compartmentss NA 50% Rat Human +DTXSID0042668 Css NA 0.1369 mg/L 3compartmentss NA 95% Rat Human +DTXSID0042668 Css NA 0.01254 mg/L PBTK NA 50% Rat Human +DTXSID0042668 Css NA 0.08341 mg/L PBTK NA 95% Rat Human +DTXSID0043761 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043761 Fup 0.0426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043761 Vd NA 1.161 L/kg 1compartment NA NA Human Human +DTXSID0043761 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0043761 TK.Half.Life NA 16.71 hours 1compartment NA NA Human Human +DTXSID0043761 Css NA 2.36 mg/L 3compartmentss NA 50% Human Human +DTXSID0043761 Css NA 18.74 mg/L 3compartmentss NA 95% Human Human +DTXSID0043761 Css NA 1.474 mg/L PBTK NA 50% Human Human +DTXSID0043761 Css NA 11.26 mg/L PBTK NA 95% Human Human +DTXSID0043761 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043761 Fup 0.0426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043761 Vd NA 0.8761 L/kg 1compartment NA NA Rat Human +DTXSID0043761 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0043761 TK.Half.Life NA 6.925 hours 1compartment NA NA Rat Human +DTXSID0043761 Css NA 0.2934 mg/L 3compartmentss NA 50% Rat Human +DTXSID0043761 Css NA 1.655 mg/L 3compartmentss NA 95% Rat Human +DTXSID0043761 Css NA 0.1779 mg/L PBTK NA 50% Rat Human +DTXSID0043761 Css NA 0.9576 mg/L PBTK NA 95% Rat Human +DTXSID0043763 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043763 Fup 0.602 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043763 Vd NA 0.5385 L/kg 1compartment NA NA Human Human DTXSID0043763 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0043763 TK.Half.Life NA 1.042 hours 1compartment NA NA Human Human -DTXSID0043763 Css NA 0.12 mg/L 3compartmentss NA 50% Human Human -DTXSID0043763 Css NA 0.6055 mg/L 3compartmentss NA 95% Human Human -DTXSID0043763 Css NA 0.0991 mg/L PBTK NA 50% Human Human -DTXSID0043763 Css NA 0.4581 mg/L PBTK NA 95% Human Human -DTXSID0043763 Clint NA 3.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043763 Fup NA 0.9811 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043763 Vd NA 0.8168 L/kg 1compartment NA NA Rat Human +DTXSID0043763 TK.Half.Life NA 5.786 hours 1compartment NA NA Human Human +DTXSID0043763 Css NA 0.6958 mg/L 3compartmentss NA 50% Human Human +DTXSID0043763 Css NA 4.773 mg/L 3compartmentss NA 95% Human Human +DTXSID0043763 Css NA 0.5342 mg/L PBTK NA 50% Human Human +DTXSID0043763 Css NA 2.996 mg/L PBTK NA 95% Human Human +DTXSID0043763 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043763 Fup 0.602 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043763 Vd NA 0.5714 L/kg 1compartment NA NA Rat Human DTXSID0043763 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0043763 TK.Half.Life NA 0.5705 hours 1compartment NA NA Rat Human -DTXSID0043763 Css NA 0.05451 mg/L 3compartmentss NA 50% Rat Human -DTXSID0043763 Css NA 0.2058 mg/L 3compartmentss NA 95% Rat Human -DTXSID0043763 Css NA 0.04502 mg/L PBTK NA 50% Rat Human -DTXSID0043763 Css NA 0.1444 mg/L PBTK NA 95% Rat Human -DTXSID0043765 Clint NA 147.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043765 Fup NA 0.5945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043765 Vd NA 0.5475 L/kg 1compartment NA NA Human Human +DTXSID0043763 TK.Half.Life NA 2.092 hours 1compartment NA NA Rat Human +DTXSID0043763 Css NA 0.003672 mg/L 3compartmentss NA 50% Rat Human +DTXSID0043763 Css NA 0.02582 mg/L 3compartmentss NA 95% Rat Human +DTXSID0043763 Css NA 0.002708 mg/L PBTK NA 50% Rat Human +DTXSID0043763 Css NA 0.01563 mg/L PBTK NA 95% Rat Human +DTXSID0043765 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043765 Fup 0.693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043765 Vd NA 0.5974 L/kg 1compartment NA NA Human Human DTXSID0043765 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0043765 TK.Half.Life NA 0.3956 hours 1compartment NA NA Human Human -DTXSID0043765 Css NA 0.005671 mg/L 3compartmentss NA 50% Human Human -DTXSID0043765 Css NA 0.06118 mg/L 3compartmentss NA 95% Human Human -DTXSID0043765 Css NA 0.004232 mg/L PBTK NA 50% Human Human -DTXSID0043765 Css NA 0.04018 mg/L PBTK NA 95% Human Human -DTXSID0043765 Clint NA 147.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043765 Fup NA 0.5945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043765 Vd NA 0.5806 L/kg 1compartment NA NA Rat Human +DTXSID0043765 TK.Half.Life NA 5.576 hours 1compartment NA NA Human Human +DTXSID0043765 Css NA 0.971 mg/L 3compartmentss NA 50% Human Human +DTXSID0043765 Css NA 6.269 mg/L 3compartmentss NA 95% Human Human +DTXSID0043765 Css NA 0.7614 mg/L PBTK NA 50% Human Human +DTXSID0043765 Css NA 3.906 mg/L PBTK NA 95% Human Human +DTXSID0043765 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043765 Fup 0.693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043765 Vd NA 0.6338 L/kg 1compartment NA NA Rat Human DTXSID0043765 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0043765 TK.Half.Life NA 0.1862 hours 1compartment NA NA Rat Human -DTXSID0043765 Css NA 0.003054 mg/L 3compartmentss NA 50% Rat Human -DTXSID0043765 Css NA 0.02995 mg/L 3compartmentss NA 95% Rat Human -DTXSID0043765 Css NA 0.002221 mg/L PBTK NA 50% Rat Human -DTXSID0043765 Css NA 0.01899 mg/L PBTK NA 95% Rat Human -DTXSID0043848 Clint NA 139.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043848 Fup NA 0.3221 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043848 Vd NA 4.092 L/kg 1compartment NA NA Human Human +DTXSID0043765 TK.Half.Life NA 2.016 hours 1compartment NA NA Rat Human +DTXSID0043765 Css NA 0.01822 mg/L 3compartmentss NA 50% Rat Human +DTXSID0043765 Css NA 0.1456 mg/L 3compartmentss NA 95% Rat Human +DTXSID0043765 Css NA 0.0138 mg/L PBTK NA 50% Rat Human +DTXSID0043765 Css NA 0.09237 mg/L PBTK NA 95% Rat Human +DTXSID0043848 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043848 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043848 Vd NA 5.069 L/kg 1compartment NA NA Human Human DTXSID0043848 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0043848 TK.Half.Life NA 2.131 hours 1compartment NA NA Human Human -DTXSID0043848 Css NA 0.00636 mg/L 3compartmentss NA 50% Human Human -DTXSID0043848 Css NA 0.0546 mg/L 3compartmentss NA 95% Human Human -DTXSID0043848 Css NA 0.007576 mg/L PBTK NA 50% Human Human -DTXSID0043848 Css NA 0.05254 mg/L PBTK NA 95% Human Human -DTXSID0043848 Clint NA 139.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043848 Fup NA 0.3221 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043848 Vd NA 4.038 L/kg 1compartment NA NA Rat Human +DTXSID0043848 TK.Half.Life NA 3.709 hours 1compartment NA NA Human Human +DTXSID0043848 Css NA 0.02358 mg/L 3compartmentss NA 50% Human Human +DTXSID0043848 Css NA 0.2365 mg/L 3compartmentss NA 95% Human Human +DTXSID0043848 Css NA 0.03304 mg/L PBTK NA 50% Human Human +DTXSID0043848 Css NA 0.2416 mg/L PBTK NA 95% Human Human +DTXSID0043848 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043848 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043848 Vd NA 5.048 L/kg 1compartment NA NA Rat Human DTXSID0043848 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0043848 TK.Half.Life NA 0.9655 hours 1compartment NA NA Rat Human -DTXSID0043848 Css NA 0.003362 mg/L 3compartmentss NA 50% Rat Human -DTXSID0043848 Css NA 0.02409 mg/L 3compartmentss NA 95% Rat Human -DTXSID0043848 Css NA 0.004041 mg/L PBTK NA 50% Rat Human -DTXSID0043848 Css NA 0.02348 mg/L PBTK NA 95% Rat Human -DTXSID0043892 Clint NA 16.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043892 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0043892 Vd NA 1.979 L/kg 1compartment NA NA Human Human -DTXSID0043892 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0043892 TK.Half.Life NA 19.14 hours 1compartment NA NA Human Human -DTXSID0043892 Css NA 1.468 mg/L 3compartmentss NA 50% Human Human -DTXSID0043892 Css NA 11.02 mg/L 3compartmentss NA 95% Human Human -DTXSID0043892 Css NA 0.9508 mg/L PBTK NA 50% Human Human -DTXSID0043892 Css NA 6.807 mg/L PBTK NA 95% Human Human -DTXSID0043892 Clint NA 16.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043892 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0043892 Vd NA 1.475 L/kg 1compartment NA NA Rat Human +DTXSID0043848 TK.Half.Life NA 1.82 hours 1compartment NA NA Rat Human +DTXSID0043848 Css NA 0.002762 mg/L 3compartmentss NA 50% Rat Human +DTXSID0043848 Css NA 0.02298 mg/L 3compartmentss NA 95% Rat Human +DTXSID0043848 Css NA 0.004114 mg/L PBTK NA 50% Rat Human +DTXSID0043848 Css NA 0.02311 mg/L PBTK NA 95% Rat Human +DTXSID0043892 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043892 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0043892 Vd NA 0.6305 L/kg 1compartment NA NA Human Human +DTXSID0043892 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0043892 TK.Half.Life NA 2.587 hours 1compartment NA NA Human Human +DTXSID0043892 Css NA 0.4237 mg/L 3compartmentss NA 50% Human Human +DTXSID0043892 Css NA 2.755 mg/L 3compartmentss NA 95% Human Human +DTXSID0043892 Css NA 0.311 mg/L PBTK NA 50% Human Human +DTXSID0043892 Css NA 1.851 mg/L PBTK NA 95% Human Human +DTXSID0043892 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043892 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0043892 Vd NA 0.6025 L/kg 1compartment NA NA Rat Human DTXSID0043892 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0043892 TK.Half.Life NA 6.205 hours 1compartment NA NA Rat Human -DTXSID0043892 Css NA 0.8075 mg/L 3compartmentss NA 50% Rat Human -DTXSID0043892 Css NA 4.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID0043892 Css NA 0.4921 mg/L PBTK NA 50% Rat Human -DTXSID0043892 Css NA 2.891 mg/L PBTK NA 95% Rat Human -DTXSID0043896 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0043892 TK.Half.Life NA 1.476 hours 1compartment NA NA Rat Human +DTXSID0043892 Css NA 0.05086 mg/L 3compartmentss NA 50% Rat Human +DTXSID0043892 Css NA 0.2501 mg/L 3compartmentss NA 95% Rat Human +DTXSID0043892 Css NA 0.03725 mg/L PBTK NA 50% Rat Human +DTXSID0043892 Css NA 0.1574 mg/L PBTK NA 95% Rat Human +DTXSID0043896 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0043896 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0043896 Vd NA 1.58 L/kg 1compartment NA NA Human Human -DTXSID0043896 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID0043896 TK.Half.Life NA 89.91 hours 1compartment NA NA Human Human -DTXSID0043896 Css NA 7.405 mg/L 3compartmentss NA 50% Human Human -DTXSID0043896 Css NA 35.79 mg/L 3compartmentss NA 95% Human Human -DTXSID0043896 Css NA 5.448 mg/L PBTK NA 50% Human Human -DTXSID0043896 Css NA 22.73 mg/L PBTK NA 95% Human Human -DTXSID0043896 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0043896 Vd NA 1.053 L/kg 1compartment NA NA Human Human +DTXSID0043896 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0043896 TK.Half.Life NA 6.048 hours 1compartment NA NA Human Human +DTXSID0043896 Css NA 0.7572 mg/L 3compartmentss NA 50% Human Human +DTXSID0043896 Css NA 5.033 mg/L 3compartmentss NA 95% Human Human +DTXSID0043896 Css NA 0.4972 mg/L PBTK NA 50% Human Human +DTXSID0043896 Css NA 3.073 mg/L PBTK NA 95% Human Human +DTXSID0043896 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0043896 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0043896 Vd NA 1.511 L/kg 1compartment NA NA Rat Human -DTXSID0043896 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID0043896 TK.Half.Life NA 28.14 hours 1compartment NA NA Rat Human -DTXSID0043896 Css NA 2.032 mg/L 3compartmentss NA 50% Rat Human -DTXSID0043896 Css NA 8.551 mg/L 3compartmentss NA 95% Rat Human -DTXSID0043896 Css NA 1.428 mg/L PBTK NA 50% Rat Human -DTXSID0043896 Css NA 5.015 mg/L PBTK NA 95% Rat Human +DTXSID0043896 Vd NA 0.8276 L/kg 1compartment NA NA Rat Human +DTXSID0043896 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0043896 TK.Half.Life NA 2.633 hours 1compartment NA NA Rat Human +DTXSID0043896 Css NA 0.09152 mg/L 3compartmentss NA 50% Rat Human +DTXSID0043896 Css NA 0.4667 mg/L 3compartmentss NA 95% Rat Human +DTXSID0043896 Css NA 0.05905 mg/L PBTK NA 50% Rat Human +DTXSID0043896 Css NA 0.275 mg/L PBTK NA 95% Rat Human DTXSID0044024 Clint 3.744 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID0044024 Fup NA 0.029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044024 Vd NA 1.099 L/kg 1compartment NA NA Human Human -DTXSID0044024 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID0044024 TK.Half.Life NA 34.21 hours 1compartment NA NA Human Human -DTXSID0044024 Css NA 5.364 mg/L 3compartmentss NA 50% Human Human -DTXSID0044024 Css NA 39.74 mg/L 3compartmentss NA 95% Human Human -DTXSID0044024 Css NA 3.32 mg/L PBTK NA 50% Human Human -DTXSID0044024 Css NA 23.85 mg/L PBTK NA 95% Human Human +DTXSID0044024 Fup 0.059 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044024 Vd NA 0.9867 L/kg 1compartment NA NA Human Human +DTXSID0044024 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0044024 TK.Half.Life NA 16.01 hours 1compartment NA NA Human Human +DTXSID0044024 Css NA 2.222 mg/L 3compartmentss NA 50% Human Human +DTXSID0044024 Css NA 14.46 mg/L 3compartmentss NA 95% Human Human +DTXSID0044024 Css NA 1.39 mg/L PBTK NA 50% Human Human +DTXSID0044024 Css NA 8.8 mg/L PBTK NA 95% Human Human DTXSID0044024 Clint 3.744 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID0044024 Fup NA 0.029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044024 Vd NA 0.8233 L/kg 1compartment NA NA Rat Human -DTXSID0044024 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0044024 TK.Half.Life NA 13.83 hours 1compartment NA NA Rat Human -DTXSID0044024 Css NA 2.776 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044024 Css NA 15.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044024 Css NA 1.605 mg/L PBTK NA 50% Rat Human -DTXSID0044024 Css NA 8.751 mg/L PBTK NA 95% Rat Human -DTXSID0044107 Clint NA 3.167 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044107 Fup NA 0.0314 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044107 Vd NA 0.2789 L/kg 1compartment NA NA Human Human +DTXSID0044024 Fup 0.059 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044024 Vd NA 0.7589 L/kg 1compartment NA NA Rat Human +DTXSID0044024 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0044024 TK.Half.Life NA 6.762 hours 1compartment NA NA Rat Human +DTXSID0044024 Css NA 0.09846 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044024 Css NA 0.7168 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044024 Css NA 0.05974 mg/L PBTK NA 50% Rat Human +DTXSID0044024 Css NA 0.4161 mg/L PBTK NA 95% Rat Human +DTXSID0044107 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044107 Fup 0.0495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044107 Vd NA 0.3333 L/kg 1compartment NA NA Human Human DTXSID0044107 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044107 TK.Half.Life NA 9.344 hours 1compartment NA NA Human Human -DTXSID0044107 Css NA 5.972 mg/L 3compartmentss NA 50% Human Human -DTXSID0044107 Css NA 45.41 mg/L 3compartmentss NA 95% Human Human -DTXSID0044107 Css NA 3.614 mg/L PBTK NA 50% Human Human -DTXSID0044107 Css NA 26.25 mg/L PBTK NA 95% Human Human -DTXSID0044107 Clint NA 3.167 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044107 Fup NA 0.0314 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044107 Vd NA 0.2693 L/kg 1compartment NA NA Rat Human +DTXSID0044107 TK.Half.Life NA 1.46 hours 1compartment NA NA Human Human +DTXSID0044107 Css NA 0.6164 mg/L 3compartmentss NA 50% Human Human +DTXSID0044107 Css NA 5.323 mg/L 3compartmentss NA 95% Human Human +DTXSID0044107 Css NA 0.3821 mg/L PBTK NA 50% Human Human +DTXSID0044107 Css NA 3.203 mg/L PBTK NA 95% Human Human +DTXSID0044107 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044107 Fup 0.0495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044107 Vd NA 0.3221 L/kg 1compartment NA NA Rat Human DTXSID0044107 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044107 TK.Half.Life NA 5.369 hours 1compartment NA NA Rat Human -DTXSID0044107 Css NA 2.942 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044107 Css NA 17.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044107 Css NA 1.671 mg/L PBTK NA 50% Rat Human -DTXSID0044107 Css NA 9.734 mg/L PBTK NA 95% Rat Human -DTXSID0044236 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044236 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044236 Vd NA 3.716 L/kg 1compartment NA NA Human Human -DTXSID0044236 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID0044236 TK.Half.Life NA 171800 hours 1compartment NA NA Human Human -DTXSID0044236 Css NA 4952 mg/L 3compartmentss NA 50% Human Human -DTXSID0044236 Css NA 11230 mg/L 3compartmentss NA 95% Human Human -DTXSID0044236 Css NA 3618 mg/L PBTK NA 50% Human Human -DTXSID0044236 Css NA 7810 mg/L PBTK NA 95% Human Human -DTXSID0044236 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044236 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044236 Vd NA 2.804 L/kg 1compartment NA NA Rat Human -DTXSID0044236 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID0044236 TK.Half.Life NA 11320 hours 1compartment NA NA Rat Human -DTXSID0044236 Css NA 1383 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044236 Css NA 2018 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044236 Css NA 968.1 mg/L PBTK NA 50% Rat Human -DTXSID0044236 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID0044280 Clint NA 6.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0044107 TK.Half.Life NA 0.8877 hours 1compartment NA NA Rat Human +DTXSID0044107 Css NA 0.07986 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044107 Css NA 0.5434 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044107 Css NA 0.04821 mg/L PBTK NA 50% Rat Human +DTXSID0044107 Css NA 0.3125 mg/L PBTK NA 95% Rat Human +DTXSID0044236 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044236 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044236 Vd NA 2.797 L/kg 1compartment NA NA Human Human +DTXSID0044236 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0044236 TK.Half.Life NA 49.55 hours 1compartment NA NA Human Human +DTXSID0044236 Css NA 2.327 mg/L 3compartmentss NA 50% Human Human +DTXSID0044236 Css NA 16.43 mg/L 3compartmentss NA 95% Human Human +DTXSID0044236 Css NA 1.57 mg/L PBTK NA 50% Human Human +DTXSID0044236 Css NA 10.58 mg/L PBTK NA 95% Human Human +DTXSID0044236 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044236 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044236 Vd NA 2.09 L/kg 1compartment NA NA Rat Human +DTXSID0044236 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID0044236 TK.Half.Life NA 9.684 hours 1compartment NA NA Rat Human +DTXSID0044236 Css NA 0.3028 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044236 Css NA 1.798 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044236 Css NA 0.2013 mg/L PBTK NA 50% Rat Human +DTXSID0044236 Css NA 1.147 mg/L PBTK NA 95% Rat Human +DTXSID0044280 Clint 1 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID0044280 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0044280 Vd NA 4.305 L/kg 1compartment NA NA Human Human -DTXSID0044280 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044280 TK.Half.Life NA 12.12 hours 1compartment NA NA Human Human -DTXSID0044280 Css NA 0.2125 mg/L 3compartmentss NA 50% Human Human -DTXSID0044280 Css NA 1.186 mg/L 3compartmentss NA 95% Human Human -DTXSID0044280 Css NA 0.1623 mg/L PBTK NA 50% Human Human -DTXSID0044280 Css NA 0.8398 mg/L PBTK NA 95% Human Human -DTXSID0044280 Clint NA 6.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0044280 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0044280 TK.Half.Life NA 48.1 hours 1compartment NA NA Human Human +DTXSID0044280 Css NA 0.9981 mg/L 3compartmentss NA 50% Human Human +DTXSID0044280 Css NA 3.749 mg/L 3compartmentss NA 95% Human Human +DTXSID0044280 Css NA 0.907 mg/L PBTK NA 50% Human Human +DTXSID0044280 Css NA 3.408 mg/L PBTK NA 95% Human Human +DTXSID0044280 Clint 1 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID0044280 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0044280 Vd NA 3.753 L/kg 1compartment NA NA Rat Human -DTXSID0044280 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044280 TK.Half.Life NA 4.814 hours 1compartment NA NA Rat Human -DTXSID0044280 Css NA 0.1496 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044280 Css NA 0.6383 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044280 Css NA 0.1125 mg/L PBTK NA 50% Rat Human -DTXSID0044280 Css NA 0.4388 mg/L PBTK NA 95% Rat Human -DTXSID0044288 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044288 Fup NA 0.1849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044288 Vd NA 0.3819 L/kg 1compartment NA NA Human Human +DTXSID0044280 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID0044280 TK.Half.Life NA 17.41 hours 1compartment NA NA Rat Human +DTXSID0044280 Css NA 0.1047 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044280 Css NA 0.2787 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044280 Css NA 0.09869 mg/L PBTK NA 50% Rat Human +DTXSID0044280 Css NA 0.2625 mg/L PBTK NA 95% Rat Human +DTXSID0044288 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044288 Fup 0.0998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044288 Vd NA 0.2354 L/kg 1compartment NA NA Human Human DTXSID0044288 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0044288 TK.Half.Life NA 13.36 hours 1compartment NA NA Human Human -DTXSID0044288 Css NA 4.352 mg/L 3compartmentss NA 50% Human Human -DTXSID0044288 Css NA 16.02 mg/L 3compartmentss NA 95% Human Human -DTXSID0044288 Css NA 2.89 mg/L PBTK NA 50% Human Human -DTXSID0044288 Css NA 9.838 mg/L PBTK NA 95% Human Human -DTXSID0044288 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044288 Fup NA 0.1849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044288 Vd NA 0.385 L/kg 1compartment NA NA Rat Human +DTXSID0044288 TK.Half.Life NA 15.26 hours 1compartment NA NA Human Human +DTXSID0044288 Css NA 5.453 mg/L 3compartmentss NA 50% Human Human +DTXSID0044288 Css NA 27.51 mg/L 3compartmentss NA 95% Human Human +DTXSID0044288 Css NA 3.324 mg/L PBTK NA 50% Human Human +DTXSID0044288 Css NA 15.79 mg/L PBTK NA 95% Human Human +DTXSID0044288 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044288 Fup 0.0998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044288 Vd NA 0.2432 L/kg 1compartment NA NA Rat Human DTXSID0044288 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044288 TK.Half.Life NA 4.59 hours 1compartment NA NA Rat Human -DTXSID0044288 Css NA 1.214 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044288 Css NA 3.788 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044288 Css NA 0.7582 mg/L PBTK NA 50% Rat Human -DTXSID0044288 Css NA 2.159 mg/L PBTK NA 95% Rat Human -DTXSID0044313 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044313 Fup NA 0.6873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044313 Vd NA 1.848 L/kg 1compartment NA NA Human Human -DTXSID0044313 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0044313 TK.Half.Life NA 23.58 hours 1compartment NA NA Human Human -DTXSID0044313 Css NA 1.256 mg/L 3compartmentss NA 50% Human Human -DTXSID0044313 Css NA 7.418 mg/L 3compartmentss NA 95% Human Human -DTXSID0044313 Css NA 1.125 mg/L PBTK NA 50% Human Human -DTXSID0044313 Css NA 4.988 mg/L PBTK NA 95% Human Human -DTXSID0044313 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044313 Fup NA 0.6873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044313 Vd NA 1.555 L/kg 1compartment NA NA Rat Human -DTXSID0044313 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044313 TK.Half.Life NA 5.411 hours 1compartment NA NA Rat Human -DTXSID0044313 Css NA 0.3284 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044313 Css NA 1.899 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044313 Css NA 0.2884 mg/L PBTK NA 50% Rat Human -DTXSID0044313 Css NA 1.182 mg/L PBTK NA 95% Rat Human +DTXSID0044288 TK.Half.Life NA 5.373 hours 1compartment NA NA Rat Human +DTXSID0044288 Css NA 0.03052 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044288 Css NA 0.1478 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044288 Css NA 0.01732 mg/L PBTK NA 50% Rat Human +DTXSID0044288 Css NA 0.08185 mg/L PBTK NA 95% Rat Human DTXSID0044315 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0044315 Fup NA 0.1389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044315 Vd NA 0.4156 L/kg 1compartment NA NA Human Human -DTXSID0044315 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0044315 TK.Half.Life NA 19.36 hours 1compartment NA NA Human Human -DTXSID0044315 Css NA 6.666 mg/L 3compartmentss NA 50% Human Human -DTXSID0044315 Css NA 30.23 mg/L 3compartmentss NA 95% Human Human -DTXSID0044315 Css NA 4.347 mg/L PBTK NA 50% Human Human -DTXSID0044315 Css NA 18.27 mg/L PBTK NA 95% Human Human +DTXSID0044315 Vd NA 0.2827 L/kg 1compartment NA NA Human Human +DTXSID0044315 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0044315 TK.Half.Life NA 13.17 hours 1compartment NA NA Human Human +DTXSID0044315 Css NA 5.918 mg/L 3compartmentss NA 50% Human Human +DTXSID0044315 Css NA 26.94 mg/L 3compartmentss NA 95% Human Human +DTXSID0044315 Css NA 3.696 mg/L PBTK NA 50% Human Human +DTXSID0044315 Css NA 15.71 mg/L PBTK NA 95% Human Human DTXSID0044315 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0044315 Fup NA 0.1389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044315 Vd NA 0.4134 L/kg 1compartment NA NA Rat Human +DTXSID0044315 Vd NA 0.2917 L/kg 1compartment NA NA Rat Human DTXSID0044315 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044315 TK.Half.Life NA 6.564 hours 1compartment NA NA Rat Human -DTXSID0044315 Css NA 1.849 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044315 Css NA 7.368 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044315 Css NA 1.139 mg/L PBTK NA 50% Rat Human -DTXSID0044315 Css NA 4.133 mg/L PBTK NA 95% Rat Human -DTXSID0044317 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044317 Fup NA 0.2634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044317 Vd NA 0.3315 L/kg 1compartment NA NA Human Human -DTXSID0044317 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044317 TK.Half.Life NA 8.142 hours 1compartment NA NA Human Human -DTXSID0044317 Css NA 3.013 mg/L 3compartmentss NA 50% Human Human -DTXSID0044317 Css NA 11.62 mg/L 3compartmentss NA 95% Human Human -DTXSID0044317 Css NA 1.987 mg/L PBTK NA 50% Human Human -DTXSID0044317 Css NA 7.1 mg/L PBTK NA 95% Human Human -DTXSID0044317 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044317 Fup NA 0.2634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044317 Vd NA 0.3451 L/kg 1compartment NA NA Rat Human -DTXSID0044317 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044317 TK.Half.Life NA 2.888 hours 1compartment NA NA Rat Human -DTXSID0044317 Css NA 0.8457 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044317 Css NA 2.622 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044317 Css NA 0.529 mg/L PBTK NA 50% Rat Human -DTXSID0044317 Css NA 1.495 mg/L PBTK NA 95% Rat Human +DTXSID0044315 TK.Half.Life NA 4.63 hours 1compartment NA NA Rat Human +DTXSID0044315 Css NA 0.1094 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044315 Css NA 0.7054 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044315 Css NA 0.06526 mg/L PBTK NA 50% Rat Human +DTXSID0044315 Css NA 0.4011 mg/L PBTK NA 95% Rat Human DTXSID0044361 Clint 0.6018 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID0044361 Fup 0.9601 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID0044361 Vd NA 0.8636 L/kg 1compartment NA NA Human Human +DTXSID0044361 Vd NA 0.6983 L/kg 1compartment NA NA Human Human DTXSID0044361 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044361 TK.Half.Life NA 3.049 hours 1compartment NA NA Human Human -DTXSID0044361 Css NA 0.3804 mg/L 3compartmentss NA 50% Human Human -DTXSID0044361 Css NA 1.172 mg/L 3compartmentss NA 95% Human Human -DTXSID0044361 Css NA 0.3284 mg/L PBTK NA 50% Human Human -DTXSID0044361 Css NA 0.9066 mg/L PBTK NA 95% Human Human +DTXSID0044361 TK.Half.Life NA 2.44 hours 1compartment NA NA Human Human +DTXSID0044361 Css NA 0.3782 mg/L 3compartmentss NA 50% Human Human +DTXSID0044361 Css NA 1.146 mg/L 3compartmentss NA 95% Human Human +DTXSID0044361 Css NA 0.3132 mg/L PBTK NA 50% Human Human +DTXSID0044361 Css NA 0.8583 mg/L PBTK NA 95% Human Human DTXSID0044361 Clint 0.6018 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID0044361 Fup 0.9601 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID0044361 Vd NA 0.8851 L/kg 1compartment NA NA Rat Human +DTXSID0044361 Vd NA 0.7443 L/kg 1compartment NA NA Rat Human DTXSID0044361 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044361 TK.Half.Life NA 1.395 hours 1compartment NA NA Rat Human -DTXSID0044361 Css NA 0.132 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044361 Css NA 0.3363 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044361 Css NA 0.1142 mg/L PBTK NA 50% Rat Human -DTXSID0044361 Css NA 0.2375 mg/L PBTK NA 95% Rat Human +DTXSID0044361 TK.Half.Life NA 1.166 hours 1compartment NA NA Rat Human +DTXSID0044361 Css NA 0.03082 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044361 Css NA 0.07578 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044361 Css NA 0.02621 mg/L PBTK NA 50% Rat Human +DTXSID0044361 Css NA 0.05386 mg/L PBTK NA 95% Rat Human DTXSID0044365 Clint NA 0.06497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0044365 Fup NA 0.8364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0044365 Vd NA 0.9852 L/kg 1compartment NA NA Human Human DTXSID0044365 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0044365 TK.Half.Life NA 7.011 hours 1compartment NA NA Human Human -DTXSID0044365 Css NA 0.8248 mg/L 3compartmentss NA 50% Human Human -DTXSID0044365 Css NA 4.868 mg/L 3compartmentss NA 95% Human Human -DTXSID0044365 Css NA 0.7166 mg/L PBTK NA 50% Human Human -DTXSID0044365 Css NA 3.212 mg/L PBTK NA 95% Human Human +DTXSID0044365 Css NA 0.7012 mg/L 3compartmentss NA 50% Human Human +DTXSID0044365 Css NA 4.298 mg/L 3compartmentss NA 95% Human Human +DTXSID0044365 Css NA 0.6122 mg/L PBTK NA 50% Human Human +DTXSID0044365 Css NA 2.826 mg/L PBTK NA 95% Human Human DTXSID0044365 Clint NA 0.06497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0044365 Fup NA 0.8364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0044365 Vd NA 0.9681 L/kg 1compartment NA NA Rat Human DTXSID0044365 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0044365 TK.Half.Life NA 2.436 hours 1compartment NA NA Rat Human -DTXSID0044365 Css NA 0.2232 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044365 Css NA 1.381 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044365 Css NA 0.1894 mg/L PBTK NA 50% Rat Human -DTXSID0044365 Css NA 0.8411 mg/L PBTK NA 95% Rat Human -DTXSID0044369 Clint NA 11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044369 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044369 Vd NA 3.358 L/kg 1compartment NA NA Human Human -DTXSID0044369 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044369 TK.Half.Life NA 2.325 hours 1compartment NA NA Human Human -DTXSID0044369 Css NA 0.03175 mg/L 3compartmentss NA 50% Human Human -DTXSID0044369 Css NA 0.3983 mg/L 3compartmentss NA 95% Human Human -DTXSID0044369 Css NA 0.0381 mg/L PBTK NA 50% Human Human -DTXSID0044369 Css NA 0.3713 mg/L PBTK NA 95% Human Human -DTXSID0044369 Clint NA 11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044369 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044369 Vd NA 3.369 L/kg 1compartment NA NA Rat Human +DTXSID0044365 Css NA 0.01406 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044365 Css NA 0.1079 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044365 Css NA 0.01182 mg/L PBTK NA 50% Rat Human +DTXSID0044365 Css NA 0.07233 mg/L PBTK NA 95% Rat Human +DTXSID0044369 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044369 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044369 Vd NA 2.558 L/kg 1compartment NA NA Human Human +DTXSID0044369 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0044369 TK.Half.Life NA 26.16 hours 1compartment NA NA Human Human +DTXSID0044369 Css NA 0.8469 mg/L 3compartmentss NA 50% Human Human +DTXSID0044369 Css NA 6.882 mg/L 3compartmentss NA 95% Human Human +DTXSID0044369 Css NA 0.9129 mg/L PBTK NA 50% Human Human +DTXSID0044369 Css NA 4.868 mg/L PBTK NA 95% Human Human +DTXSID0044369 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044369 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044369 Vd NA 2.552 L/kg 1compartment NA NA Rat Human DTXSID0044369 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044369 TK.Half.Life NA 1.195 hours 1compartment NA NA Rat Human -DTXSID0044369 Css NA 0.01503 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044369 Css NA 0.1482 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044369 Css NA 0.01865 mg/L PBTK NA 50% Rat Human -DTXSID0044369 Css NA 0.1235 mg/L PBTK NA 95% Rat Human -DTXSID0044440 Clint NA 50.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044440 Fup NA 0.0313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044440 Vd NA 2.813 L/kg 1compartment NA NA Human Human -DTXSID0044440 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0044440 TK.Half.Life NA 16.62 hours 1compartment NA NA Human Human -DTXSID0044440 Css NA 0.7102 mg/L 3compartmentss NA 50% Human Human -DTXSID0044440 Css NA 4.956 mg/L 3compartmentss NA 95% Human Human -DTXSID0044440 Css NA 0.4836 mg/L PBTK NA 50% Human Human -DTXSID0044440 Css NA 3.238 mg/L PBTK NA 95% Human Human -DTXSID0044440 Clint NA 50.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044440 Fup NA 0.0313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044440 Vd NA 2.105 L/kg 1compartment NA NA Rat Human -DTXSID0044440 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044440 TK.Half.Life NA 3.454 hours 1compartment NA NA Rat Human -DTXSID0044440 Css NA 0.4027 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044440 Css NA 2.265 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044440 Css NA 0.2603 mg/L PBTK NA 50% Rat Human -DTXSID0044440 Css NA 1.41 mg/L PBTK NA 95% Rat Human +DTXSID0044369 TK.Half.Life NA 8.574 hours 1compartment NA NA Rat Human +DTXSID0044369 Css NA 0.05004 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044369 Css NA 0.3878 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044369 Css NA 0.05534 mg/L PBTK NA 50% Rat Human +DTXSID0044369 Css NA 0.2613 mg/L PBTK NA 95% Rat Human +DTXSID0044440 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044440 Fup 0.0194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044440 Vd NA 2.644 L/kg 1compartment NA NA Human Human +DTXSID0044440 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID0044440 TK.Half.Life NA 36.52 hours 1compartment NA NA Human Human +DTXSID0044440 Css NA 1.866 mg/L 3compartmentss NA 50% Human Human +DTXSID0044440 Css NA 13.41 mg/L 3compartmentss NA 95% Human Human +DTXSID0044440 Css NA 1.243 mg/L PBTK NA 50% Human Human +DTXSID0044440 Css NA 8.729 mg/L PBTK NA 95% Human Human +DTXSID0044440 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044440 Fup 0.0194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044440 Vd NA 1.974 L/kg 1compartment NA NA Rat Human +DTXSID0044440 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0044440 TK.Half.Life NA 8.154 hours 1compartment NA NA Rat Human +DTXSID0044440 Css NA 0.243 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044440 Css NA 1.427 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044440 Css NA 0.1593 mg/L PBTK NA 50% Rat Human +DTXSID0044440 Css NA 0.9065 mg/L PBTK NA 95% Rat Human DTXSID0044446 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0044446 Fup NA 0.8965 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044446 Vd NA 0.8727 L/kg 1compartment NA NA Human Human +DTXSID0044446 Vd NA 0.71 L/kg 1compartment NA NA Human Human DTXSID0044446 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044446 TK.Half.Life NA 6.296 hours 1compartment NA NA Human Human -DTXSID0044446 Css NA 0.8415 mg/L 3compartmentss NA 50% Human Human -DTXSID0044446 Css NA 3.377 mg/L 3compartmentss NA 95% Human Human -DTXSID0044446 Css NA 0.7396 mg/L PBTK NA 50% Human Human -DTXSID0044446 Css NA 2.367 mg/L PBTK NA 95% Human Human +DTXSID0044446 TK.Half.Life NA 5.123 hours 1compartment NA NA Human Human +DTXSID0044446 Css NA 0.7622 mg/L 3compartmentss NA 50% Human Human +DTXSID0044446 Css NA 2.956 mg/L 3compartmentss NA 95% Human Human +DTXSID0044446 Css NA 0.6302 mg/L PBTK NA 50% Human Human +DTXSID0044446 Css NA 2.013 mg/L PBTK NA 95% Human Human DTXSID0044446 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0044446 Fup NA 0.8965 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044446 Vd NA 0.8972 L/kg 1compartment NA NA Rat Human +DTXSID0044446 Vd NA 0.749 L/kg 1compartment NA NA Rat Human DTXSID0044446 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044446 TK.Half.Life NA 2.207 hours 1compartment NA NA Rat Human -DTXSID0044446 Css NA 0.2149 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044446 Css NA 0.8177 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044446 Css NA 0.185 mg/L PBTK NA 50% Rat Human -DTXSID0044446 Css NA 0.5327 mg/L PBTK NA 95% Rat Human -DTXSID0044448 Clint NA 0.02447 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044448 Fup NA 0.4483 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044448 Vd NA 0.4162 L/kg 1compartment NA NA Human Human +DTXSID0044446 TK.Half.Life NA 1.842 hours 1compartment NA NA Rat Human +DTXSID0044446 Css NA 0.01388 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044446 Css NA 0.07157 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044446 Css NA 0.01098 mg/L PBTK NA 50% Rat Human +DTXSID0044446 Css NA 0.05193 mg/L PBTK NA 95% Rat Human +DTXSID0044448 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044448 Fup 0.711 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044448 Vd NA 0.5607 L/kg 1compartment NA NA Human Human DTXSID0044448 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044448 TK.Half.Life NA 5.771 hours 1compartment NA NA Human Human -DTXSID0044448 Css NA 1.616 mg/L 3compartmentss NA 50% Human Human -DTXSID0044448 Css NA 7.56 mg/L 3compartmentss NA 95% Human Human -DTXSID0044448 Css NA 1.15 mg/L PBTK NA 50% Human Human -DTXSID0044448 Css NA 4.651 mg/L PBTK NA 95% Human Human -DTXSID0044448 Clint NA 0.02447 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044448 Fup NA 0.4483 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044448 Vd NA 0.4216 L/kg 1compartment NA NA Rat Human +DTXSID0044448 TK.Half.Life NA 5.104 hours 1compartment NA NA Human Human +DTXSID0044448 Css NA 0.9496 mg/L 3compartmentss NA 50% Human Human +DTXSID0044448 Css NA 6.19 mg/L 3compartmentss NA 95% Human Human +DTXSID0044448 Css NA 0.7437 mg/L PBTK NA 50% Human Human +DTXSID0044448 Css NA 3.861 mg/L PBTK NA 95% Human Human +DTXSID0044448 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044448 Fup 0.711 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044448 Vd NA 0.5668 L/kg 1compartment NA NA Rat Human DTXSID0044448 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044448 TK.Half.Life NA 2.034 hours 1compartment NA NA Rat Human -DTXSID0044448 Css NA 0.4558 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044448 Css NA 1.817 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044448 Css NA 0.3082 mg/L PBTK NA 50% Rat Human -DTXSID0044448 Css NA 1.053 mg/L PBTK NA 95% Rat Human -DTXSID0044490 Clint NA 1.464 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044490 Fup NA 0.4575 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044490 Vd NA 0.5948 L/kg 1compartment NA NA Human Human -DTXSID0044490 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044490 TK.Half.Life NA 2.68 hours 1compartment NA NA Human Human -DTXSID0044490 Css NA 0.4752 mg/L 3compartmentss NA 50% Human Human -DTXSID0044490 Css NA 2.638 mg/L 3compartmentss NA 95% Human Human -DTXSID0044490 Css NA 0.3571 mg/L PBTK NA 50% Human Human -DTXSID0044490 Css NA 1.705 mg/L PBTK NA 95% Human Human -DTXSID0044490 Clint NA 1.464 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044490 Fup NA 0.4575 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044490 Vd NA 0.5916 L/kg 1compartment NA NA Rat Human +DTXSID0044448 TK.Half.Life NA 1.758 hours 1compartment NA NA Rat Human +DTXSID0044448 Css NA 0.01843 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044448 Css NA 0.1435 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044448 Css NA 0.01384 mg/L PBTK NA 50% Rat Human +DTXSID0044448 Css NA 0.08995 mg/L PBTK NA 95% Rat Human +DTXSID0044490 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044490 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044490 Vd NA 0.5078 L/kg 1compartment NA NA Human Human +DTXSID0044490 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0044490 TK.Half.Life NA 11.24 hours 1compartment NA NA Human Human +DTXSID0044490 Css NA 2.539 mg/L 3compartmentss NA 50% Human Human +DTXSID0044490 Css NA 9.907 mg/L 3compartmentss NA 95% Human Human +DTXSID0044490 Css NA 1.776 mg/L PBTK NA 50% Human Human +DTXSID0044490 Css NA 6.195 mg/L PBTK NA 95% Human Human +DTXSID0044490 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044490 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044490 Vd NA 0.4945 L/kg 1compartment NA NA Rat Human DTXSID0044490 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044490 TK.Half.Life NA 1.366 hours 1compartment NA NA Rat Human -DTXSID0044490 Css NA 0.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044490 Css NA 0.9404 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044490 Css NA 0.1446 mg/L PBTK NA 50% Rat Human -DTXSID0044490 Css NA 0.5564 mg/L PBTK NA 95% Rat Human +DTXSID0044490 TK.Half.Life NA 3.713 hours 1compartment NA NA Rat Human +DTXSID0044490 Css NA 0.1638 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044490 Css NA 0.5249 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044490 Css NA 0.1119 mg/L PBTK NA 50% Rat Human +DTXSID0044490 Css NA 0.3167 mg/L PBTK NA 95% Rat Human DTXSID0044494 Clint 57.48 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID0044494 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044494 Vd NA 2.069 L/kg 1compartment NA NA Human Human +DTXSID0044494 Fup 0.0108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044494 Vd NA 1.566 L/kg 1compartment NA NA Human Human DTXSID0044494 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044494 TK.Half.Life NA 6.646 hours 1compartment NA NA Human Human -DTXSID0044494 Css NA 0.3872 mg/L 3compartmentss NA 50% Human Human -DTXSID0044494 Css NA 2.723 mg/L 3compartmentss NA 95% Human Human -DTXSID0044494 Css NA 0.2516 mg/L PBTK NA 50% Human Human -DTXSID0044494 Css NA 1.711 mg/L PBTK NA 95% Human Human +DTXSID0044494 TK.Half.Life NA 9.399 hours 1compartment NA NA Human Human +DTXSID0044494 Css NA 0.8739 mg/L 3compartmentss NA 50% Human Human +DTXSID0044494 Css NA 7.854 mg/L 3compartmentss NA 95% Human Human +DTXSID0044494 Css NA 0.5412 mg/L PBTK NA 50% Human Human +DTXSID0044494 Css NA 4.741 mg/L PBTK NA 95% Human Human DTXSID0044494 Clint 57.48 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID0044494 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044494 Vd NA 1.545 L/kg 1compartment NA NA Rat Human +DTXSID0044494 Fup 0.0108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044494 Vd NA 1.156 L/kg 1compartment NA NA Rat Human DTXSID0044494 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044494 TK.Half.Life NA 2.122 hours 1compartment NA NA Rat Human -DTXSID0044494 Css NA 0.2186 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044494 Css NA 1.283 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044494 Css NA 0.1344 mg/L PBTK NA 50% Rat Human -DTXSID0044494 Css NA 0.7559 mg/L PBTK NA 95% Rat Human -DTXSID0044496 Clint NA 0.06949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044496 Fup NA 0.2034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044496 Vd NA 2.388 L/kg 1compartment NA NA Human Human -DTXSID0044496 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID0044496 TK.Half.Life NA 166.9 hours 1compartment NA NA Human Human -DTXSID0044496 Css NA 7.709 mg/L 3compartmentss NA 50% Human Human -DTXSID0044496 Css NA 23.82 mg/L 3compartmentss NA 95% Human Human -DTXSID0044496 Css NA 5.618 mg/L PBTK NA 50% Human Human -DTXSID0044496 Css NA 15.61 mg/L PBTK NA 95% Human Human -DTXSID0044496 Clint NA 0.06949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044496 Fup NA 0.2034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044496 Vd NA 1.824 L/kg 1compartment NA NA Rat Human -DTXSID0044496 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID0044496 TK.Half.Life NA 25.15 hours 1compartment NA NA Rat Human -DTXSID0044496 Css NA 2.292 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044496 Css NA 5.609 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044496 Css NA 1.601 mg/L PBTK NA 50% Rat Human -DTXSID0044496 Css NA 3.444 mg/L PBTK NA 95% Rat Human +DTXSID0044494 TK.Half.Life NA 3.527 hours 1compartment NA NA Rat Human +DTXSID0044494 Css NA 0.1156 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044494 Css NA 0.9016 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044494 Css NA 0.06987 mg/L PBTK NA 50% Rat Human +DTXSID0044494 Css NA 0.526 mg/L PBTK NA 95% Rat Human +DTXSID0044496 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044496 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044496 Vd NA 2.452 L/kg 1compartment NA NA Human Human +DTXSID0044496 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0044496 TK.Half.Life NA 5.369 hours 1compartment NA NA Human Human +DTXSID0044496 Css NA 0.1677 mg/L 3compartmentss NA 50% Human Human +DTXSID0044496 Css NA 1.087 mg/L 3compartmentss NA 95% Human Human +DTXSID0044496 Css NA 0.124 mg/L PBTK NA 50% Human Human +DTXSID0044496 Css NA 0.7562 mg/L PBTK NA 95% Human Human +DTXSID0044496 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044496 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044496 Vd NA 1.88 L/kg 1compartment NA NA Rat Human +DTXSID0044496 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0044496 TK.Half.Life NA 1.557 hours 1compartment NA NA Rat Human +DTXSID0044496 Css NA 0.02142 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044496 Css NA 0.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044496 Css NA 0.0158 mg/L PBTK NA 50% Rat Human +DTXSID0044496 Css NA 0.0713 mg/L PBTK NA 95% Rat Human DTXSID0044521 Clint NA 4.088 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0044521 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0044521 Vd NA 0.9991 L/kg 1compartment NA NA Human Human +DTXSID0044521 Vd NA 1.995 L/kg 1compartment NA NA Human Human DTXSID0044521 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044521 TK.Half.Life NA 1.204 hours 1compartment NA NA Human Human -DTXSID0044521 Css NA 0.1003 mg/L 3compartmentss NA 50% Human Human -DTXSID0044521 Css NA 0.9031 mg/L 3compartmentss NA 95% Human Human -DTXSID0044521 Css NA 0.09266 mg/L PBTK NA 50% Human Human -DTXSID0044521 Css NA 0.6823 mg/L PBTK NA 95% Human Human +DTXSID0044521 TK.Half.Life NA 2.182 hours 1compartment NA NA Human Human +DTXSID0044521 Css NA 0.05763 mg/L 3compartmentss NA 50% Human Human +DTXSID0044521 Css NA 0.6586 mg/L 3compartmentss NA 95% Human Human +DTXSID0044521 Css NA 0.07794 mg/L PBTK NA 50% Human Human +DTXSID0044521 Css NA 0.6192 mg/L PBTK NA 95% Human Human DTXSID0044521 Clint NA 4.088 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0044521 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0044521 Vd NA 1.012 L/kg 1compartment NA NA Rat Human +DTXSID0044521 Vd NA 1.989 L/kg 1compartment NA NA Rat Human DTXSID0044521 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044521 TK.Half.Life NA 0.646 hours 1compartment NA NA Rat Human -DTXSID0044521 Css NA 0.04524 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044521 Css NA 0.3333 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044521 Css NA 0.04199 mg/L PBTK NA 50% Rat Human -DTXSID0044521 Css NA 0.2217 mg/L PBTK NA 95% Rat Human -DTXSID0044523 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044523 Fup NA 0.4596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044523 Vd NA 0.4011 L/kg 1compartment NA NA Human Human +DTXSID0044521 TK.Half.Life NA 1.192 hours 1compartment NA NA Rat Human +DTXSID0044521 Css NA 0.002424 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044521 Css NA 0.02782 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044521 Css NA 0.003404 mg/L PBTK NA 50% Rat Human +DTXSID0044521 Css NA 0.02699 mg/L PBTK NA 95% Rat Human +DTXSID0044523 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044523 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044523 Vd NA 0.5061 L/kg 1compartment NA NA Human Human DTXSID0044523 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044523 TK.Half.Life NA 5.645 hours 1compartment NA NA Human Human -DTXSID0044523 Css NA 1.643 mg/L 3compartmentss NA 50% Human Human -DTXSID0044523 Css NA 7.714 mg/L 3compartmentss NA 95% Human Human -DTXSID0044523 Css NA 1.166 mg/L PBTK NA 50% Human Human -DTXSID0044523 Css NA 4.742 mg/L PBTK NA 95% Human Human -DTXSID0044523 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044523 Fup NA 0.4596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044523 Vd NA 0.4198 L/kg 1compartment NA NA Rat Human +DTXSID0044523 TK.Half.Life NA 8.731 hours 1compartment NA NA Human Human +DTXSID0044523 Css NA 1.888 mg/L 3compartmentss NA 50% Human Human +DTXSID0044523 Css NA 8.182 mg/L 3compartmentss NA 95% Human Human +DTXSID0044523 Css NA 1.385 mg/L PBTK NA 50% Human Human +DTXSID0044523 Css NA 5.1 mg/L PBTK NA 95% Human Human +DTXSID0044523 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044523 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044523 Vd NA 0.5152 L/kg 1compartment NA NA Rat Human DTXSID0044523 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044523 TK.Half.Life NA 2.014 hours 1compartment NA NA Rat Human -DTXSID0044523 Css NA 0.4557 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044523 Css NA 1.803 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044523 Css NA 0.3082 mg/L PBTK NA 50% Rat Human -DTXSID0044523 Css NA 1.046 mg/L PBTK NA 95% Rat Human -DTXSID0044525 Clint NA 6.116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044525 Fup NA 0.1135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044525 Vd NA 1.365 L/kg 1compartment NA NA Human Human -DTXSID0044525 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044525 TK.Half.Life NA 8.917 hours 1compartment NA NA Human Human -DTXSID0044525 Css NA 0.9064 mg/L 3compartmentss NA 50% Human Human -DTXSID0044525 Css NA 5.744 mg/L 3compartmentss NA 95% Human Human -DTXSID0044525 Css NA 0.6002 mg/L PBTK NA 50% Human Human -DTXSID0044525 Css NA 3.587 mg/L PBTK NA 95% Human Human -DTXSID0044525 Clint NA 6.116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044525 Fup NA 0.1135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044525 Vd NA 1.056 L/kg 1compartment NA NA Rat Human -DTXSID0044525 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044525 TK.Half.Life NA 3.575 hours 1compartment NA NA Rat Human -DTXSID0044525 Css NA 0.4663 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044525 Css NA 2.251 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044525 Css NA 0.2941 mg/L PBTK NA 50% Rat Human -DTXSID0044525 Css NA 1.302 mg/L PBTK NA 95% Rat Human -DTXSID0044527 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044527 Fup NA 0.751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044527 Vd NA 0.4618 L/kg 1compartment NA NA Human Human +DTXSID0044523 TK.Half.Life NA 3.029 hours 1compartment NA NA Rat Human +DTXSID0044523 Css NA 0.12 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044523 Css NA 0.446 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044523 Css NA 0.08689 mg/L PBTK NA 50% Rat Human +DTXSID0044523 Css NA 0.2729 mg/L PBTK NA 95% Rat Human +DTXSID0044527 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044527 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044527 Vd NA 0.4363 L/kg 1compartment NA NA Human Human DTXSID0044527 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044527 TK.Half.Life NA 3.979 hours 1compartment NA NA Human Human -DTXSID0044527 Css NA 1.136 mg/L 3compartmentss NA 50% Human Human -DTXSID0044527 Css NA 6.536 mg/L 3compartmentss NA 95% Human Human -DTXSID0044527 Css NA 0.8462 mg/L PBTK NA 50% Human Human -DTXSID0044527 Css NA 4.069 mg/L PBTK NA 95% Human Human -DTXSID0044527 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044527 Fup NA 0.751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044527 Vd NA 0.4816 L/kg 1compartment NA NA Rat Human +DTXSID0044527 TK.Half.Life NA 7.431 hours 1compartment NA NA Human Human +DTXSID0044527 Css NA 1.914 mg/L 3compartmentss NA 50% Human Human +DTXSID0044527 Css NA 8.085 mg/L 3compartmentss NA 95% Human Human +DTXSID0044527 Css NA 1.37 mg/L PBTK NA 50% Human Human +DTXSID0044527 Css NA 5.086 mg/L PBTK NA 95% Human Human +DTXSID0044527 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044527 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044527 Vd NA 0.4382 L/kg 1compartment NA NA Rat Human DTXSID0044527 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044527 TK.Half.Life NA 1.414 hours 1compartment NA NA Rat Human -DTXSID0044527 Css NA 0.2958 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044527 Css NA 1.729 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044527 Css NA 0.2106 mg/L PBTK NA 50% Rat Human -DTXSID0044527 Css NA 0.9965 mg/L PBTK NA 95% Rat Human +DTXSID0044527 TK.Half.Life NA 2.542 hours 1compartment NA NA Rat Human +DTXSID0044527 Css NA 0.122 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044527 Css NA 0.4314 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044527 Css NA 0.08594 mg/L PBTK NA 50% Rat Human +DTXSID0044527 Css NA 0.2616 mg/L PBTK NA 95% Rat Human DTXSID0044571 Clint 19.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0044571 Fup 0.14 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0044571 Vd NA 2.143 L/kg 1compartment NA NA Human Human +DTXSID0044571 Vd NA 2.157 L/kg 1compartment NA NA Human Human DTXSID0044571 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044571 TK.Half.Life NA 6.336 hours 1compartment NA NA Human Human -DTXSID0044571 Css NA 0.2731 mg/L 3compartmentss NA 50% Human Human -DTXSID0044571 Css NA 1.71 mg/L 3compartmentss NA 95% Human Human -DTXSID0044571 Css NA 0.1928 mg/L PBTK NA 50% Human Human -DTXSID0044571 Css NA 1.173 mg/L PBTK NA 95% Human Human +DTXSID0044571 TK.Half.Life NA 6.424 hours 1compartment NA NA Human Human +DTXSID0044571 Css NA 0.259 mg/L 3compartmentss NA 50% Human Human +DTXSID0044571 Css NA 1.744 mg/L 3compartmentss NA 95% Human Human +DTXSID0044571 Css NA 0.1832 mg/L PBTK NA 50% Human Human +DTXSID0044571 Css NA 1.2 mg/L PBTK NA 95% Human Human DTXSID0044571 Clint 19.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0044571 Fup 0.14 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0044571 Vd NA 1.631 L/kg 1compartment NA NA Rat Human +DTXSID0044571 Vd NA 1.641 L/kg 1compartment NA NA Rat Human DTXSID0044571 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044571 TK.Half.Life NA 2.014 hours 1compartment NA NA Rat Human -DTXSID0044571 Css NA 0.1476 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044571 Css NA 0.703 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044571 Css NA 0.09978 mg/L PBTK NA 50% Rat Human -DTXSID0044571 Css NA 0.458 mg/L PBTK NA 95% Rat Human -DTXSID0044575 Clint NA 5.072 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044575 Fup NA 0.2083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044575 Vd NA 2.788 L/kg 1compartment NA NA Human Human -DTXSID0044575 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0044575 TK.Half.Life NA 32.63 hours 1compartment NA NA Human Human -DTXSID0044575 Css NA 1.327 mg/L 3compartmentss NA 50% Human Human -DTXSID0044575 Css NA 6.602 mg/L 3compartmentss NA 95% Human Human -DTXSID0044575 Css NA 0.96 mg/L PBTK NA 50% Human Human -DTXSID0044575 Css NA 4.554 mg/L PBTK NA 95% Human Human -DTXSID0044575 Clint NA 5.072 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044575 Fup NA 0.2083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044575 Vd NA 2.119 L/kg 1compartment NA NA Rat Human -DTXSID0044575 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0044575 TK.Half.Life NA 6.601 hours 1compartment NA NA Rat Human -DTXSID0044575 Css NA 0.6796 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044575 Css NA 2.467 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044575 Css NA 0.4736 mg/L PBTK NA 50% Rat Human -DTXSID0044575 Css NA 1.624 mg/L PBTK NA 95% Rat Human -DTXSID0044577 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044577 Fup NA 0.7313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044577 Vd NA 3.048 L/kg 1compartment NA NA Human Human -DTXSID0044577 Days.Css NA 56 Days PBTK NA NA Human Human -DTXSID0044577 TK.Half.Life NA 260.6 hours 1compartment NA NA Human Human -DTXSID0044577 Css NA 9.227 mg/L 3compartmentss NA 50% Human Human -DTXSID0044577 Css NA 28.35 mg/L 3compartmentss NA 95% Human Human -DTXSID0044577 Css NA 7.031 mg/L PBTK NA 50% Human Human -DTXSID0044577 Css NA 19.41 mg/L PBTK NA 95% Human Human -DTXSID0044577 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044577 Fup NA 0.7313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044577 Vd NA 2.33 L/kg 1compartment NA NA Rat Human -DTXSID0044577 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID0044577 TK.Half.Life NA 21.52 hours 1compartment NA NA Rat Human -DTXSID0044577 Css NA 2.477 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044577 Css NA 6.404 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044577 Css NA 1.825 mg/L PBTK NA 50% Rat Human -DTXSID0044577 Css NA 4.028 mg/L PBTK NA 95% Rat Human -DTXSID0044600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044600 Fup NA 0.7134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044600 Vd NA 1.296 L/kg 1compartment NA NA Human Human -DTXSID0044600 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0044600 TK.Half.Life NA 12.87 hours 1compartment NA NA Human Human -DTXSID0044600 Css NA 1.032 mg/L 3compartmentss NA 50% Human Human -DTXSID0044600 Css NA 6.835 mg/L 3compartmentss NA 95% Human Human -DTXSID0044600 Css NA 0.9172 mg/L PBTK NA 50% Human Human -DTXSID0044600 Css NA 4.541 mg/L PBTK NA 95% Human Human -DTXSID0044600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044600 Fup NA 0.7134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044600 Vd NA 1.174 L/kg 1compartment NA NA Rat Human +DTXSID0044571 TK.Half.Life NA 2.029 hours 1compartment NA NA Rat Human +DTXSID0044571 Css NA 0.03367 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044571 Css NA 0.1673 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044571 Css NA 0.0236 mg/L PBTK NA 50% Rat Human +DTXSID0044571 Css NA 0.114 mg/L PBTK NA 95% Rat Human +DTXSID0044575 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044575 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044575 Vd NA 2.799 L/kg 1compartment NA NA Human Human +DTXSID0044575 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0044575 TK.Half.Life NA 13.68 hours 1compartment NA NA Human Human +DTXSID0044575 Css NA 0.5165 mg/L 3compartmentss NA 50% Human Human +DTXSID0044575 Css NA 3.476 mg/L 3compartmentss NA 95% Human Human +DTXSID0044575 Css NA 0.3631 mg/L PBTK NA 50% Human Human +DTXSID0044575 Css NA 2.34 mg/L PBTK NA 95% Human Human +DTXSID0044575 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044575 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044575 Vd NA 2.115 L/kg 1compartment NA NA Rat Human +DTXSID0044575 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0044575 TK.Half.Life NA 2.997 hours 1compartment NA NA Rat Human +DTXSID0044575 Css NA 0.06686 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044575 Css NA 0.3428 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044575 Css NA 0.04662 mg/L PBTK NA 50% Rat Human +DTXSID0044575 Css NA 0.234 mg/L PBTK NA 95% Rat Human +DTXSID0044600 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044600 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044600 Vd NA 1.086 L/kg 1compartment NA NA Human Human +DTXSID0044600 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0044600 TK.Half.Life NA 1.036 hours 1compartment NA NA Human Human +DTXSID0044600 Css NA 0.03661 mg/L 3compartmentss NA 50% Human Human +DTXSID0044600 Css NA 0.3474 mg/L 3compartmentss NA 95% Human Human +DTXSID0044600 Css NA 0.02982 mg/L PBTK NA 50% Human Human +DTXSID0044600 Css NA 0.2517 mg/L PBTK NA 95% Human Human +DTXSID0044600 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044600 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044600 Vd NA 0.9808 L/kg 1compartment NA NA Rat Human DTXSID0044600 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044600 TK.Half.Life NA 3.711 hours 1compartment NA NA Rat Human -DTXSID0044600 Css NA 0.2676 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044600 Css NA 1.752 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044600 Css NA 0.2321 mg/L PBTK NA 50% Rat Human -DTXSID0044600 Css NA 1.071 mg/L PBTK NA 95% Rat Human -DTXSID0044606 Clint NA 59.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044606 Fup NA 0.1887 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044606 Vd NA 0.6936 L/kg 1compartment NA NA Human Human +DTXSID0044600 TK.Half.Life NA 0.4646 hours 1compartment NA NA Rat Human +DTXSID0044600 Css NA 0.0045 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044600 Css NA 0.03409 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044600 Css NA 0.003723 mg/L PBTK NA 50% Rat Human +DTXSID0044600 Css NA 0.02341 mg/L PBTK NA 95% Rat Human +DTXSID0044604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044604 Fup 0.0977 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044604 Vd NA 2.676 L/kg 1compartment NA NA Human Human +DTXSID0044604 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0044604 TK.Half.Life NA 14.25 hours 1compartment NA NA Human Human +DTXSID0044604 Css NA 0.6022 mg/L 3compartmentss NA 50% Human Human +DTXSID0044604 Css NA 3.972 mg/L 3compartmentss NA 95% Human Human +DTXSID0044604 Css NA 0.4164 mg/L PBTK NA 50% Human Human +DTXSID0044604 Css NA 2.62 mg/L PBTK NA 95% Human Human +DTXSID0044604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044604 Fup 0.0977 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044604 Vd NA 2.014 L/kg 1compartment NA NA Rat Human +DTXSID0044604 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0044604 TK.Half.Life NA 3.318 hours 1compartment NA NA Rat Human +DTXSID0044604 Css NA 0.07704 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044604 Css NA 0.4094 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044604 Css NA 0.05267 mg/L PBTK NA 50% Rat Human +DTXSID0044604 Css NA 0.2704 mg/L PBTK NA 95% Rat Human +DTXSID0044606 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044606 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044606 Vd NA 1.498 L/kg 1compartment NA NA Human Human DTXSID0044606 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044606 TK.Half.Life NA 0.7945 hours 1compartment NA NA Human Human -DTXSID0044606 Css NA 0.0443 mg/L 3compartmentss NA 50% Human Human -DTXSID0044606 Css NA 0.3199 mg/L 3compartmentss NA 95% Human Human -DTXSID0044606 Css NA 0.03032 mg/L PBTK NA 50% Human Human -DTXSID0044606 Css NA 0.2067 mg/L PBTK NA 95% Human Human -DTXSID0044606 Clint NA 59.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044606 Fup NA 0.1887 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044606 Vd NA 0.6067 L/kg 1compartment NA NA Rat Human +DTXSID0044606 TK.Half.Life NA 4.058 hours 1compartment NA NA Human Human +DTXSID0044606 Css NA 0.234 mg/L 3compartmentss NA 50% Human Human +DTXSID0044606 Css NA 1.424 mg/L 3compartmentss NA 95% Human Human +DTXSID0044606 Css NA 0.1786 mg/L PBTK NA 50% Human Human +DTXSID0044606 Css NA 1.011 mg/L PBTK NA 95% Human Human +DTXSID0044606 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044606 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044606 Vd NA 1.22 L/kg 1compartment NA NA Rat Human DTXSID0044606 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044606 TK.Half.Life NA 0.3485 hours 1compartment NA NA Rat Human -DTXSID0044606 Css NA 0.02457 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044606 Css NA 0.1401 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044606 Css NA 0.01596 mg/L PBTK NA 50% Rat Human -DTXSID0044606 Css NA 0.08673 mg/L PBTK NA 95% Rat Human -DTXSID0044650 Clint NA 36.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044650 Fup NA 0.3898 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044650 Vd NA 0.8266 L/kg 1compartment NA NA Human Human -DTXSID0044650 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044650 TK.Half.Life NA 0.7949 hours 1compartment NA NA Human Human -DTXSID0044650 Css NA 0.03223 mg/L 3compartmentss NA 50% Human Human -DTXSID0044650 Css NA 0.2485 mg/L 3compartmentss NA 95% Human Human -DTXSID0044650 Css NA 0.02432 mg/L PBTK NA 50% Human Human -DTXSID0044650 Css NA 0.171 mg/L PBTK NA 95% Human Human -DTXSID0044650 Clint NA 36.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044650 Fup NA 0.3898 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044650 Vd NA 0.7609 L/kg 1compartment NA NA Rat Human +DTXSID0044606 TK.Half.Life NA 1.658 hours 1compartment NA NA Rat Human +DTXSID0044606 Css NA 0.02724 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044606 Css NA 0.1235 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044606 Css NA 0.02081 mg/L PBTK NA 50% Rat Human +DTXSID0044606 Css NA 0.08295 mg/L PBTK NA 95% Rat Human +DTXSID0044608 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044608 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044608 Vd NA 0.9165 L/kg 1compartment NA NA Human Human +DTXSID0044608 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0044608 TK.Half.Life NA 0.9817 hours 1compartment NA NA Human Human +DTXSID0044608 Css NA 0.0448 mg/L 3compartmentss NA 50% Human Human +DTXSID0044608 Css NA 0.3712 mg/L 3compartmentss NA 95% Human Human +DTXSID0044608 Css NA 0.03468 mg/L PBTK NA 50% Human Human +DTXSID0044608 Css NA 0.2598 mg/L PBTK NA 95% Human Human +DTXSID0044608 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044608 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044608 Vd NA 0.8346 L/kg 1compartment NA NA Rat Human +DTXSID0044608 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0044608 TK.Half.Life NA 0.4542 hours 1compartment NA NA Rat Human +DTXSID0044608 Css NA 0.005508 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044608 Css NA 0.03486 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044608 Css NA 0.004315 mg/L PBTK NA 50% Rat Human +DTXSID0044608 Css NA 0.02406 mg/L PBTK NA 95% Rat Human +DTXSID0044650 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044650 Fup 0.592 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044650 Vd NA 1.061 L/kg 1compartment NA NA Human Human +DTXSID0044650 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0044650 TK.Half.Life NA 12.22 hours 1compartment NA NA Human Human +DTXSID0044650 Css NA 1.186 mg/L 3compartmentss NA 50% Human Human +DTXSID0044650 Css NA 8.427 mg/L 3compartmentss NA 95% Human Human +DTXSID0044650 Css NA 1.003 mg/L PBTK NA 50% Human Human +DTXSID0044650 Css NA 5.295 mg/L PBTK NA 95% Human Human +DTXSID0044650 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044650 Fup 0.592 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044650 Vd NA 0.9789 L/kg 1compartment NA NA Rat Human DTXSID0044650 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044650 TK.Half.Life NA 0.3597 hours 1compartment NA NA Rat Human -DTXSID0044650 Css NA 0.01737 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044650 Css NA 0.1125 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044650 Css NA 0.01275 mg/L PBTK NA 50% Rat Human -DTXSID0044650 Css NA 0.07463 mg/L PBTK NA 95% Rat Human -DTXSID0044654 Clint NA 11.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044654 Fup NA 0.2491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044654 Vd NA 3.553 L/kg 1compartment NA NA Human Human +DTXSID0044650 TK.Half.Life NA 3.693 hours 1compartment NA NA Rat Human +DTXSID0044650 Css NA 0.07248 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044650 Css NA 0.4708 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044650 Css NA 0.06118 mg/L PBTK NA 50% Rat Human +DTXSID0044650 Css NA 0.2917 mg/L PBTK NA 95% Rat Human +DTXSID0044654 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044654 Fup 0.288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044654 Vd NA 0.8544 L/kg 1compartment NA NA Human Human DTXSID0044654 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044654 TK.Half.Life NA 6.261 hours 1compartment NA NA Human Human -DTXSID0044654 Css NA 0.1084 mg/L 3compartmentss NA 50% Human Human -DTXSID0044654 Css NA 0.7882 mg/L 3compartmentss NA 95% Human Human -DTXSID0044654 Css NA 0.1148 mg/L PBTK NA 50% Human Human -DTXSID0044654 Css NA 0.6934 mg/L PBTK NA 95% Human Human -DTXSID0044654 Clint NA 11.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044654 Fup NA 0.2491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044654 Vd NA 3.419 L/kg 1compartment NA NA Rat Human +DTXSID0044654 TK.Half.Life NA 2.277 hours 1compartment NA NA Human Human +DTXSID0044654 Css NA 0.2348 mg/L 3compartmentss NA 50% Human Human +DTXSID0044654 Css NA 1.485 mg/L 3compartmentss NA 95% Human Human +DTXSID0044654 Css NA 0.1708 mg/L PBTK NA 50% Human Human +DTXSID0044654 Css NA 0.9914 mg/L PBTK NA 95% Human Human +DTXSID0044654 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044654 Fup 0.288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044654 Vd NA 0.7461 L/kg 1compartment NA NA Rat Human DTXSID0044654 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044654 TK.Half.Life NA 3.1 hours 1compartment NA NA Rat Human -DTXSID0044654 Css NA 0.05602 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044654 Css NA 0.3031 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044654 Css NA 0.05916 mg/L PBTK NA 50% Rat Human -DTXSID0044654 Css NA 0.2645 mg/L PBTK NA 95% Rat Human -DTXSID0044656 Clint NA 32.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044656 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044656 Vd NA 1.038 L/kg 1compartment NA NA Human Human +DTXSID0044654 TK.Half.Life NA 1.108 hours 1compartment NA NA Rat Human +DTXSID0044654 Css NA 0.02786 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044654 Css NA 0.1271 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044654 Css NA 0.02009 mg/L PBTK NA 50% Rat Human +DTXSID0044654 Css NA 0.08268 mg/L PBTK NA 95% Rat Human +DTXSID0044656 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044656 Fup 0.7 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044656 Vd NA 0.8364 L/kg 1compartment NA NA Human Human DTXSID0044656 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044656 TK.Half.Life NA 0.6466 hours 1compartment NA NA Human Human -DTXSID0044656 Css NA 0.015 mg/L 3compartmentss NA 50% Human Human -DTXSID0044656 Css NA 0.2076 mg/L 3compartmentss NA 95% Human Human -DTXSID0044656 Css NA 0.01321 mg/L PBTK NA 50% Human Human -DTXSID0044656 Css NA 0.1566 mg/L PBTK NA 95% Human Human -DTXSID0044656 Clint NA 32.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044656 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044656 Vd NA 1.033 L/kg 1compartment NA NA Rat Human +DTXSID0044656 TK.Half.Life NA 7.815 hours 1compartment NA NA Human Human +DTXSID0044656 Css NA 1.031 mg/L 3compartmentss NA 50% Human Human +DTXSID0044656 Css NA 6.763 mg/L 3compartmentss NA 95% Human Human +DTXSID0044656 Css NA 0.8616 mg/L PBTK NA 50% Human Human +DTXSID0044656 Css NA 4.421 mg/L PBTK NA 95% Human Human +DTXSID0044656 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044656 Fup 0.7 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044656 Vd NA 0.8297 L/kg 1compartment NA NA Rat Human DTXSID0044656 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044656 TK.Half.Life NA 0.299 hours 1compartment NA NA Rat Human -DTXSID0044656 Css NA 0.007552 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044656 Css NA 0.08412 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044656 Css NA 0.006634 mg/L PBTK NA 50% Rat Human -DTXSID0044656 Css NA 0.063 mg/L PBTK NA 95% Rat Human -DTXSID0044658 Clint NA 0.9012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044658 Fup NA 0.8664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044658 Vd NA 1.952 L/kg 1compartment NA NA Human Human -DTXSID0044658 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044658 TK.Half.Life NA 6.145 hours 1compartment NA NA Human Human -DTXSID0044658 Css NA 0.309 mg/L 3compartmentss NA 50% Human Human -DTXSID0044658 Css NA 2.278 mg/L 3compartmentss NA 95% Human Human -DTXSID0044658 Css NA 0.3156 mg/L PBTK NA 50% Human Human -DTXSID0044658 Css NA 1.588 mg/L PBTK NA 95% Human Human -DTXSID0044658 Clint NA 0.9012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044658 Fup NA 0.8664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044658 Vd NA 1.937 L/kg 1compartment NA NA Rat Human +DTXSID0044656 TK.Half.Life NA 2.62 hours 1compartment NA NA Rat Human +DTXSID0044656 Css NA 0.06147 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044656 Css NA 0.3926 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044656 Css NA 0.05156 mg/L PBTK NA 50% Rat Human +DTXSID0044656 Css NA 0.243 mg/L PBTK NA 95% Rat Human +DTXSID0044658 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044658 Fup 0.559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044658 Vd NA 1.687 L/kg 1compartment NA NA Human Human +DTXSID0044658 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0044658 TK.Half.Life NA 19.53 hours 1compartment NA NA Human Human +DTXSID0044658 Css NA 1.054 mg/L 3compartmentss NA 50% Human Human +DTXSID0044658 Css NA 8.253 mg/L 3compartmentss NA 95% Human Human +DTXSID0044658 Css NA 1.009 mg/L PBTK NA 50% Human Human +DTXSID0044658 Css NA 5.517 mg/L PBTK NA 95% Human Human +DTXSID0044658 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044658 Fup 0.559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044658 Vd NA 1.679 L/kg 1compartment NA NA Rat Human DTXSID0044658 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044658 TK.Half.Life NA 2.919 hours 1compartment NA NA Rat Human -DTXSID0044658 Css NA 0.1112 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044658 Css NA 0.7509 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044658 Css NA 0.1145 mg/L PBTK NA 50% Rat Human -DTXSID0044658 Css NA 0.4938 mg/L PBTK NA 95% Rat Human -DTXSID0044731 Clint NA 0.108 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044731 Fup NA 0.06 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044731 Vd NA 0.5343 L/kg 1compartment NA NA Human Human -DTXSID0044731 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID0044731 TK.Half.Life NA 50.08 hours 1compartment NA NA Human Human -DTXSID0044731 Css NA 14.94 mg/L 3compartmentss NA 50% Human Human -DTXSID0044731 Css NA 68.55 mg/L 3compartmentss NA 95% Human Human -DTXSID0044731 Css NA 9.176 mg/L PBTK NA 50% Human Human -DTXSID0044731 Css NA 39.95 mg/L PBTK NA 95% Human Human -DTXSID0044731 Clint NA 0.108 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044731 Fup NA 0.06 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044731 Vd NA 0.4383 L/kg 1compartment NA NA Rat Human -DTXSID0044731 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0044731 TK.Half.Life NA 14.86 hours 1compartment NA NA Rat Human -DTXSID0044731 Css NA 4.699 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044731 Css NA 18.39 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044731 Css NA 2.694 mg/L PBTK NA 50% Rat Human -DTXSID0044731 Css NA 10.09 mg/L PBTK NA 95% Rat Human -DTXSID0044733 Clint NA 0.352 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044733 Fup NA 0.1581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044733 Vd NA 0.4111 L/kg 1compartment NA NA Human Human -DTXSID0044733 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0044733 TK.Half.Life NA 10.66 hours 1compartment NA NA Human Human -DTXSID0044733 Css NA 3.375 mg/L 3compartmentss NA 50% Human Human -DTXSID0044733 Css NA 15.41 mg/L 3compartmentss NA 95% Human Human -DTXSID0044733 Css NA 2.242 mg/L PBTK NA 50% Human Human -DTXSID0044733 Css NA 9.204 mg/L PBTK NA 95% Human Human -DTXSID0044733 Clint NA 0.352 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044733 Fup NA 0.1581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044733 Vd NA 0.4086 L/kg 1compartment NA NA Rat Human +DTXSID0044658 TK.Half.Life NA 6.627 hours 1compartment NA NA Rat Human +DTXSID0044658 Css NA 0.06327 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044658 Css NA 0.482 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044658 Css NA 0.06155 mg/L PBTK NA 50% Rat Human +DTXSID0044658 Css NA 0.3094 mg/L PBTK NA 95% Rat Human +DTXSID0044731 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044731 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044731 Vd NA 0.5309 L/kg 1compartment NA NA Human Human +DTXSID0044731 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0044731 TK.Half.Life NA 1.114 hours 1compartment NA NA Human Human +DTXSID0044731 Css NA 0.1918 mg/L 3compartmentss NA 50% Human Human +DTXSID0044731 Css NA 1.64 mg/L 3compartmentss NA 95% Human Human +DTXSID0044731 Css NA 0.1232 mg/L PBTK NA 50% Human Human +DTXSID0044731 Css NA 0.9989 mg/L PBTK NA 95% Human Human +DTXSID0044731 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044731 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044731 Vd NA 0.469 L/kg 1compartment NA NA Rat Human +DTXSID0044731 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0044731 TK.Half.Life NA 0.5622 hours 1compartment NA NA Rat Human +DTXSID0044731 Css NA 0.02545 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044731 Css NA 0.1557 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044731 Css NA 0.01593 mg/L PBTK NA 50% Rat Human +DTXSID0044731 Css NA 0.09201 mg/L PBTK NA 95% Rat Human +DTXSID0044733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044733 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044733 Vd NA 0.454 L/kg 1compartment NA NA Human Human +DTXSID0044733 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0044733 TK.Half.Life NA 0.7168 hours 1compartment NA NA Human Human +DTXSID0044733 Css NA 0.09772 mg/L 3compartmentss NA 50% Human Human +DTXSID0044733 Css NA 0.7046 mg/L 3compartmentss NA 95% Human Human +DTXSID0044733 Css NA 0.06757 mg/L PBTK NA 50% Human Human +DTXSID0044733 Css NA 0.4618 mg/L PBTK NA 95% Human Human +DTXSID0044733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044733 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044733 Vd NA 0.4535 L/kg 1compartment NA NA Rat Human DTXSID0044733 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044733 TK.Half.Life NA 4.446 hours 1compartment NA NA Rat Human -DTXSID0044733 Css NA 1.197 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044733 Css NA 4.631 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044733 Css NA 0.7486 mg/L PBTK NA 50% Rat Human -DTXSID0044733 Css NA 2.623 mg/L PBTK NA 95% Rat Human +DTXSID0044733 TK.Half.Life NA 0.3954 hours 1compartment NA NA Rat Human +DTXSID0044733 Css NA 0.01253 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044733 Css NA 0.06854 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044733 Css NA 0.008498 mg/L PBTK NA 50% Rat Human +DTXSID0044733 Css NA 0.04404 mg/L PBTK NA 95% Rat Human DTXSID0044735 Clint NA 5.172e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0044735 Fup NA 0.3532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044735 Vd NA 0.447 L/kg 1compartment NA NA Human Human +DTXSID0044735 Vd NA 0.4013 L/kg 1compartment NA NA Human Human DTXSID0044735 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044735 TK.Half.Life NA 8.185 hours 1compartment NA NA Human Human -DTXSID0044735 Css NA 2.114 mg/L 3compartmentss NA 50% Human Human -DTXSID0044735 Css NA 9.05 mg/L 3compartmentss NA 95% Human Human -DTXSID0044735 Css NA 1.503 mg/L PBTK NA 50% Human Human -DTXSID0044735 Css NA 5.6 mg/L PBTK NA 95% Human Human +DTXSID0044735 TK.Half.Life NA 7.349 hours 1compartment NA NA Human Human +DTXSID0044735 Css NA 1.836 mg/L 3compartmentss NA 50% Human Human +DTXSID0044735 Css NA 7.63 mg/L 3compartmentss NA 95% Human Human +DTXSID0044735 Css NA 1.279 mg/L PBTK NA 50% Human Human +DTXSID0044735 Css NA 4.718 mg/L PBTK NA 95% Human Human DTXSID0044735 Clint NA 5.172e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0044735 Fup NA 0.3532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044735 Vd NA 0.4643 L/kg 1compartment NA NA Rat Human +DTXSID0044735 Vd NA 0.4248 L/kg 1compartment NA NA Rat Human DTXSID0044735 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044735 TK.Half.Life NA 2.899 hours 1compartment NA NA Rat Human -DTXSID0044735 Css NA 0.5876 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044735 Css NA 2.076 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044735 Css NA 0.3948 mg/L PBTK NA 50% Rat Human -DTXSID0044735 Css NA 1.21 mg/L PBTK NA 95% Rat Human -DTXSID0044737 Clint NA 19.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044737 Fup NA 0.1501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044737 Vd NA 0.9493 L/kg 1compartment NA NA Human Human +DTXSID0044735 TK.Half.Life NA 2.653 hours 1compartment NA NA Rat Human +DTXSID0044735 Css NA 0.03338 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044735 Css NA 0.2115 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044735 Css NA 0.02234 mg/L PBTK NA 50% Rat Human +DTXSID0044735 Css NA 0.129 mg/L PBTK NA 95% Rat Human +DTXSID0044737 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044737 Fup 0.384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044737 Vd NA 1.222 L/kg 1compartment NA NA Human Human DTXSID0044737 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044737 TK.Half.Life NA 2.034 hours 1compartment NA NA Human Human -DTXSID0044737 Css NA 0.202 mg/L 3compartmentss NA 50% Human Human -DTXSID0044737 Css NA 1.57 mg/L 3compartmentss NA 95% Human Human -DTXSID0044737 Css NA 0.135 mg/L PBTK NA 50% Human Human -DTXSID0044737 Css NA 0.9748 mg/L PBTK NA 95% Human Human -DTXSID0044737 Clint NA 19.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044737 Fup NA 0.1501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044737 Vd NA 0.7724 L/kg 1compartment NA NA Rat Human +DTXSID0044737 TK.Half.Life NA 2.682 hours 1compartment NA NA Human Human +DTXSID0044737 Css NA 0.1729 mg/L 3compartmentss NA 50% Human Human +DTXSID0044737 Css NA 1.126 mg/L 3compartmentss NA 95% Human Human +DTXSID0044737 Css NA 0.1352 mg/L PBTK NA 50% Human Human +DTXSID0044737 Css NA 0.7873 mg/L PBTK NA 95% Human Human +DTXSID0044737 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044737 Fup 0.384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044737 Vd NA 1.041 L/kg 1compartment NA NA Rat Human DTXSID0044737 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044737 TK.Half.Life NA 0.9114 hours 1compartment NA NA Rat Human -DTXSID0044737 Css NA 0.1108 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044737 Css NA 0.6724 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044737 Css NA 0.07036 mg/L PBTK NA 50% Rat Human -DTXSID0044737 Css NA 0.3978 mg/L PBTK NA 95% Rat Human -DTXSID0044783 Clint NA 129.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044783 Fup NA 0.1774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044783 Vd NA 1.173 L/kg 1compartment NA NA Human Human -DTXSID0044783 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044783 TK.Half.Life NA 1.143 hours 1compartment NA NA Human Human -DTXSID0044783 Css NA 0.0232 mg/L 3compartmentss NA 50% Human Human -DTXSID0044783 Css NA 0.175 mg/L 3compartmentss NA 95% Human Human -DTXSID0044783 Css NA 0.01622 mg/L PBTK NA 50% Human Human -DTXSID0044783 Css NA 0.1149 mg/L PBTK NA 95% Human Human -DTXSID0044783 Clint NA 129.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044783 Fup NA 0.1774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044783 Vd NA 0.9415 L/kg 1compartment NA NA Rat Human -DTXSID0044783 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044783 TK.Half.Life NA 0.4281 hours 1compartment NA NA Rat Human -DTXSID0044783 Css NA 0.01308 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044783 Css NA 0.08012 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044783 Css NA 0.008724 mg/L PBTK NA 50% Rat Human -DTXSID0044783 Css NA 0.05004 mg/L PBTK NA 95% Rat Human -DTXSID0044785 Clint NA 0.6222 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044785 Fup NA 0.2444 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044785 Vd NA 0.4205 L/kg 1compartment NA NA Human Human +DTXSID0044737 TK.Half.Life NA 1.205 hours 1compartment NA NA Rat Human +DTXSID0044737 Css NA 0.02014 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044737 Css NA 0.09877 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044737 Css NA 0.0158 mg/L PBTK NA 50% Rat Human +DTXSID0044737 Css NA 0.0672 mg/L PBTK NA 95% Rat Human +DTXSID0044785 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044785 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044785 Vd NA 0.3183 L/kg 1compartment NA NA Human Human DTXSID0044785 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044785 TK.Half.Life NA 5.545 hours 1compartment NA NA Human Human -DTXSID0044785 Css NA 1.525 mg/L 3compartmentss NA 50% Human Human -DTXSID0044785 Css NA 6.147 mg/L 3compartmentss NA 95% Human Human -DTXSID0044785 Css NA 1.057 mg/L PBTK NA 50% Human Human -DTXSID0044785 Css NA 3.864 mg/L PBTK NA 95% Human Human -DTXSID0044785 Clint NA 0.6222 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044785 Fup NA 0.2444 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044785 Vd NA 0.4215 L/kg 1compartment NA NA Rat Human +DTXSID0044785 TK.Half.Life NA 6.98 hours 1compartment NA NA Human Human +DTXSID0044785 Css NA 2.654 mg/L 3compartmentss NA 50% Human Human +DTXSID0044785 Css NA 10.08 mg/L 3compartmentss NA 95% Human Human +DTXSID0044785 Css NA 1.759 mg/L PBTK NA 50% Human Human +DTXSID0044785 Css NA 6.172 mg/L PBTK NA 95% Human Human +DTXSID0044785 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044785 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044785 Vd NA 0.3355 L/kg 1compartment NA NA Rat Human DTXSID0044785 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044785 TK.Half.Life NA 2.545 hours 1compartment NA NA Rat Human -DTXSID0044785 Css NA 0.579 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044785 Css NA 1.957 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044785 Css NA 0.3791 mg/L PBTK NA 50% Rat Human -DTXSID0044785 Css NA 1.134 mg/L PBTK NA 95% Rat Human -DTXSID0044787 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044787 Fup NA 0.0239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044787 Vd NA 0.2513 L/kg 1compartment NA NA Human Human -DTXSID0044787 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID0044787 TK.Half.Life NA 68.22 hours 1compartment NA NA Human Human -DTXSID0044787 Css NA 46.35 mg/L 3compartmentss NA 50% Human Human -DTXSID0044787 Css NA 279.9 mg/L 3compartmentss NA 95% Human Human -DTXSID0044787 Css NA 27.52 mg/L PBTK NA 50% Human Human -DTXSID0044787 Css NA 163.1 mg/L PBTK NA 95% Human Human -DTXSID0044787 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044787 Fup NA 0.0239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044787 Vd NA 0.2317 L/kg 1compartment NA NA Rat Human -DTXSID0044787 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0044787 TK.Half.Life NA 21.39 hours 1compartment NA NA Rat Human -DTXSID0044787 Css NA 13.29 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044787 Css NA 68.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044787 Css NA 7.367 mg/L PBTK NA 50% Rat Human -DTXSID0044787 Css NA 36.99 mg/L PBTK NA 95% Rat Human -DTXSID0044810 Clint NA 24.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044810 Fup NA 0.1501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044810 Vd NA 2.813 L/kg 1compartment NA NA Human Human -DTXSID0044810 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044810 TK.Half.Life NA 12.18 hours 1compartment NA NA Human Human -DTXSID0044810 Css NA 0.4583 mg/L 3compartmentss NA 50% Human Human -DTXSID0044810 Css NA 2.944 mg/L 3compartmentss NA 95% Human Human -DTXSID0044810 Css NA 0.3234 mg/L PBTK NA 50% Human Human -DTXSID0044810 Css NA 2.007 mg/L PBTK NA 95% Human Human -DTXSID0044810 Clint NA 24.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044810 Fup NA 0.1501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044810 Vd NA 2.123 L/kg 1compartment NA NA Rat Human -DTXSID0044810 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044810 TK.Half.Life NA 2.652 hours 1compartment NA NA Rat Human -DTXSID0044810 Css NA 0.2523 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044810 Css NA 1.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044810 Css NA 0.1712 mg/L PBTK NA 50% Rat Human -DTXSID0044810 Css NA 0.8337 mg/L PBTK NA 95% Rat Human -DTXSID0044812 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044812 Fup NA 0.9294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044812 Vd NA 0.9786 L/kg 1compartment NA NA Human Human +DTXSID0044785 TK.Half.Life NA 2.508 hours 1compartment NA NA Rat Human +DTXSID0044785 Css NA 0.1705 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044785 Css NA 0.5408 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044785 Css NA 0.1106 mg/L PBTK NA 50% Rat Human +DTXSID0044785 Css NA 0.3193 mg/L PBTK NA 95% Rat Human +DTXSID0044787 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044787 Fup 0.0437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044787 Vd NA 0.5465 L/kg 1compartment NA NA Human Human +DTXSID0044787 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0044787 TK.Half.Life NA 7.314 hours 1compartment NA NA Human Human +DTXSID0044787 Css NA 2.236 mg/L 3compartmentss NA 50% Human Human +DTXSID0044787 Css NA 16.35 mg/L 3compartmentss NA 95% Human Human +DTXSID0044787 Css NA 1.364 mg/L PBTK NA 50% Human Human +DTXSID0044787 Css NA 9.677 mg/L PBTK NA 95% Human Human +DTXSID0044787 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044787 Fup 0.0437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044787 Vd NA 0.4391 L/kg 1compartment NA NA Rat Human +DTXSID0044787 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0044787 TK.Half.Life NA 3.597 hours 1compartment NA NA Rat Human +DTXSID0044787 Css NA 0.2731 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044787 Css NA 1.632 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044787 Css NA 0.1608 mg/L PBTK NA 50% Rat Human +DTXSID0044787 Css NA 0.9272 mg/L PBTK NA 95% Rat Human +DTXSID0044812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044812 Fup 0.683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044812 Vd NA 0.8837 L/kg 1compartment NA NA Human Human DTXSID0044812 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044812 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human -DTXSID0044812 Css NA 0.8672 mg/L 3compartmentss NA 50% Human Human -DTXSID0044812 Css NA 5.162 mg/L 3compartmentss NA 95% Human Human -DTXSID0044812 Css NA 0.7588 mg/L PBTK NA 50% Human Human -DTXSID0044812 Css NA 3.404 mg/L PBTK NA 95% Human Human -DTXSID0044812 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044812 Fup NA 0.9294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044812 Vd NA 0.9763 L/kg 1compartment NA NA Rat Human +DTXSID0044812 TK.Half.Life NA 0.7375 hours 1compartment NA NA Human Human +DTXSID0044812 Css NA 0.02342 mg/L 3compartmentss NA 50% Human Human +DTXSID0044812 Css NA 0.2855 mg/L 3compartmentss NA 95% Human Human +DTXSID0044812 Css NA 0.01931 mg/L PBTK NA 50% Human Human +DTXSID0044812 Css NA 0.2003 mg/L PBTK NA 95% Human Human +DTXSID0044812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044812 Fup 0.683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044812 Vd NA 0.8644 L/kg 1compartment NA NA Rat Human DTXSID0044812 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044812 TK.Half.Life NA 2.323 hours 1compartment NA NA Rat Human -DTXSID0044812 Css NA 0.2214 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044812 Css NA 1.255 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044812 Css NA 0.1889 mg/L PBTK NA 50% Rat Human -DTXSID0044812 Css NA 0.7738 mg/L PBTK NA 95% Rat Human -DTXSID0044816 Clint NA 6.217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044816 Fup NA 0.3247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044816 Vd NA 1.467 L/kg 1compartment NA NA Human Human -DTXSID0044816 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044816 TK.Half.Life NA 3.923 hours 1compartment NA NA Human Human -DTXSID0044816 Css NA 0.2372 mg/L 3compartmentss NA 50% Human Human -DTXSID0044816 Css NA 1.477 mg/L 3compartmentss NA 95% Human Human -DTXSID0044816 Css NA 0.1824 mg/L PBTK NA 50% Human Human -DTXSID0044816 Css NA 1.038 mg/L PBTK NA 95% Human Human -DTXSID0044816 Clint NA 6.217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044816 Fup NA 0.3247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044816 Vd NA 1.197 L/kg 1compartment NA NA Rat Human -DTXSID0044816 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044816 TK.Half.Life NA 1.615 hours 1compartment NA NA Rat Human -DTXSID0044816 Css NA 0.1204 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044816 Css NA 0.5457 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044816 Css NA 0.08924 mg/L PBTK NA 50% Rat Human -DTXSID0044816 Css NA 0.3548 mg/L PBTK NA 95% Rat Human +DTXSID0044812 TK.Half.Life NA 0.3538 hours 1compartment NA NA Rat Human +DTXSID0044812 Css NA 0.000836 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044812 Css NA 0.01194 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044812 Css NA 0.0006878 mg/L PBTK NA 50% Rat Human +DTXSID0044812 Css NA 0.008118 mg/L PBTK NA 95% Rat Human DTXSID0044818 Clint 0.658 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID0044818 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID0044818 Vd NA 3.142 L/kg 1compartment NA NA Human Human -DTXSID0044818 Days.Css NA 370 Days PBTK NA NA Human Human -DTXSID0044818 TK.Half.Life NA 1433 hours 1compartment NA NA Human Human -DTXSID0044818 Css NA 54.25 mg/L 3compartmentss NA 50% Human Human -DTXSID0044818 Css NA 236.9 mg/L 3compartmentss NA 95% Human Human -DTXSID0044818 Css NA 38.1 mg/L PBTK NA 50% Human Human -DTXSID0044818 Css NA 157.2 mg/L PBTK NA 95% Human Human +DTXSID0044818 Vd NA 3.139 L/kg 1compartment NA NA Human Human +DTXSID0044818 Days.Css NA 650 Days PBTK NA NA Human Human +DTXSID0044818 TK.Half.Life NA 2446 hours 1compartment NA NA Human Human +DTXSID0044818 Css NA 93.26 mg/L 3compartmentss NA 50% Human Human +DTXSID0044818 Css NA 492.6 mg/L 3compartmentss NA 95% Human Human +DTXSID0044818 Css NA 65 mg/L PBTK NA 50% Human Human +DTXSID0044818 Css NA 335.5 mg/L PBTK NA 95% Human Human DTXSID0044818 Clint 0.658 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID0044818 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID0044818 Vd NA 2.357 L/kg 1compartment NA NA Rat Human -DTXSID0044818 Days.Css NA 171 Days PBTK NA NA Rat Human -DTXSID0044818 TK.Half.Life NA 157.1 hours 1compartment NA NA Rat Human -DTXSID0044818 Css NA 26.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044818 Css NA 77.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044818 Css NA 17.83 mg/L PBTK NA 50% Rat Human -DTXSID0044818 Css NA 49.28 mg/L PBTK NA 95% Rat Human -DTXSID0044860 Clint NA 1.056 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044860 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044860 Vd NA 2.567 L/kg 1compartment NA NA Human Human +DTXSID0044818 Vd NA 2.352 L/kg 1compartment NA NA Rat Human +DTXSID0044818 Days.Css NA 327 Days PBTK NA NA Rat Human +DTXSID0044818 TK.Half.Life NA 291.5 hours 1compartment NA NA Rat Human +DTXSID0044818 Css NA 11.44 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044818 Css NA 44.33 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044818 Css NA 7.876 mg/L PBTK NA 50% Rat Human +DTXSID0044818 Css NA 29.84 mg/L PBTK NA 95% Rat Human +DTXSID0044860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044860 Fup 0.672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044860 Vd NA 1.955 L/kg 1compartment NA NA Human Human DTXSID0044860 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044860 TK.Half.Life NA 6.533 hours 1compartment NA NA Human Human -DTXSID0044860 Css NA 0.2327 mg/L 3compartmentss NA 50% Human Human -DTXSID0044860 Css NA 1.833 mg/L 3compartmentss NA 95% Human Human -DTXSID0044860 Css NA 0.2555 mg/L PBTK NA 50% Human Human -DTXSID0044860 Css NA 1.397 mg/L PBTK NA 95% Human Human -DTXSID0044860 Clint NA 1.056 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044860 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044860 Vd NA 2.603 L/kg 1compartment NA NA Rat Human +DTXSID0044860 TK.Half.Life NA 1.456 hours 1compartment NA NA Human Human +DTXSID0044860 Css NA 0.01997 mg/L 3compartmentss NA 50% Human Human +DTXSID0044860 Css NA 0.2676 mg/L 3compartmentss NA 95% Human Human +DTXSID0044860 Css NA 0.01924 mg/L PBTK NA 50% Human Human +DTXSID0044860 Css NA 0.2026 mg/L PBTK NA 95% Human Human +DTXSID0044860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044860 Fup 0.672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044860 Vd NA 1.972 L/kg 1compartment NA NA Rat Human DTXSID0044860 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044860 TK.Half.Life NA 3.205 hours 1compartment NA NA Rat Human -DTXSID0044860 Css NA 0.0864 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044860 Css NA 0.6712 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044860 Css NA 0.09636 mg/L PBTK NA 50% Rat Human -DTXSID0044860 Css NA 0.4487 mg/L PBTK NA 95% Rat Human -DTXSID0044862 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044862 Fup NA 0.2073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044862 Vd NA 0.5406 L/kg 1compartment NA NA Human Human +DTXSID0044860 TK.Half.Life NA 0.7397 hours 1compartment NA NA Rat Human +DTXSID0044860 Css NA 0.0006876 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044860 Css NA 0.0108 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044860 Css NA 0.000679 mg/L PBTK NA 50% Rat Human +DTXSID0044860 Css NA 0.008092 mg/L PBTK NA 95% Rat Human +DTXSID0044862 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044862 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044862 Vd NA 0.5683 L/kg 1compartment NA NA Human Human DTXSID0044862 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0044862 TK.Half.Life NA 16.89 hours 1compartment NA NA Human Human -DTXSID0044862 Css NA 3.472 mg/L 3compartmentss NA 50% Human Human -DTXSID0044862 Css NA 13.15 mg/L 3compartmentss NA 95% Human Human -DTXSID0044862 Css NA 2.54 mg/L PBTK NA 50% Human Human -DTXSID0044862 Css NA 8.515 mg/L PBTK NA 95% Human Human -DTXSID0044862 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044862 Fup NA 0.2073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044862 Vd NA 0.5319 L/kg 1compartment NA NA Rat Human +DTXSID0044862 TK.Half.Life NA 16.81 hours 1compartment NA NA Human Human +DTXSID0044862 Css NA 3.13 mg/L 3compartmentss NA 50% Human Human +DTXSID0044862 Css NA 11.9 mg/L 3compartmentss NA 95% Human Human +DTXSID0044862 Css NA 2.332 mg/L PBTK NA 50% Human Human +DTXSID0044862 Css NA 7.74 mg/L PBTK NA 95% Human Human +DTXSID0044862 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044862 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044862 Vd NA 0.5592 L/kg 1compartment NA NA Rat Human DTXSID0044862 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044862 TK.Half.Life NA 5.658 hours 1compartment NA NA Rat Human -DTXSID0044862 Css NA 0.9626 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044862 Css NA 3.048 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044862 Css NA 0.6706 mg/L PBTK NA 50% Rat Human -DTXSID0044862 Css NA 1.822 mg/L PBTK NA 95% Rat Human -DTXSID0044868 Clint NA 1.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044868 Fup NA 0.3461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044868 Vd NA 0.9815 L/kg 1compartment NA NA Human Human +DTXSID0044862 TK.Half.Life NA 5.631 hours 1compartment NA NA Rat Human +DTXSID0044862 Css NA 0.2013 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044862 Css NA 0.6485 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044862 Css NA 0.148 mg/L PBTK NA 50% Rat Human +DTXSID0044862 Css NA 0.4044 mg/L PBTK NA 95% Rat Human +DTXSID0044868 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044868 Fup 0.36 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044868 Vd NA 1.004 L/kg 1compartment NA NA Human Human DTXSID0044868 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044868 TK.Half.Life NA 7.234 hours 1compartment NA NA Human Human -DTXSID0044868 Css NA 0.763 mg/L 3compartmentss NA 50% Human Human -DTXSID0044868 Css NA 3.681 mg/L 3compartmentss NA 95% Human Human -DTXSID0044868 Css NA 0.5806 mg/L PBTK NA 50% Human Human -DTXSID0044868 Css NA 2.41 mg/L PBTK NA 95% Human Human -DTXSID0044868 Clint NA 1.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044868 Fup NA 0.3461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044868 Vd NA 0.8594 L/kg 1compartment NA NA Rat Human +DTXSID0044868 TK.Half.Life NA 1.184 hours 1compartment NA NA Human Human +DTXSID0044868 Css NA 0.055 mg/L 3compartmentss NA 50% Human Human +DTXSID0044868 Css NA 0.4361 mg/L 3compartmentss NA 95% Human Human +DTXSID0044868 Css NA 0.04194 mg/L PBTK NA 50% Human Human +DTXSID0044868 Css NA 0.3033 mg/L PBTK NA 95% Human Human +DTXSID0044868 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044868 Fup 0.36 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044868 Vd NA 0.879 L/kg 1compartment NA NA Rat Human DTXSID0044868 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044868 TK.Half.Life NA 3.002 hours 1compartment NA NA Rat Human -DTXSID0044868 Css NA 0.3174 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044868 Css NA 1.186 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044868 Css NA 0.2326 mg/L PBTK NA 50% Rat Human -DTXSID0044868 Css NA 0.7259 mg/L PBTK NA 95% Rat Human -DTXSID0044941 Clint NA 4.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044941 Fup NA 0.1334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044941 Vd NA 0.9836 L/kg 1compartment NA NA Human Human +DTXSID0044868 TK.Half.Life NA 0.5303 hours 1compartment NA NA Rat Human +DTXSID0044868 Css NA 0.006882 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044868 Css NA 0.03967 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044868 Css NA 0.00525 mg/L PBTK NA 50% Rat Human +DTXSID0044868 Css NA 0.02724 mg/L PBTK NA 95% Rat Human +DTXSID0044941 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044941 Fup 0.0965 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044941 Vd NA 0.8375 L/kg 1compartment NA NA Human Human DTXSID0044941 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044941 TK.Half.Life NA 6.822 hours 1compartment NA NA Human Human -DTXSID0044941 Css NA 0.9442 mg/L 3compartmentss NA 50% Human Human -DTXSID0044941 Css NA 6.133 mg/L 3compartmentss NA 95% Human Human -DTXSID0044941 Css NA 0.6248 mg/L PBTK NA 50% Human Human -DTXSID0044941 Css NA 3.787 mg/L PBTK NA 95% Human Human -DTXSID0044941 Clint NA 4.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044941 Fup NA 0.1334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044941 Vd NA 0.7897 L/kg 1compartment NA NA Rat Human +DTXSID0044941 TK.Half.Life NA 2.225 hours 1compartment NA NA Human Human +DTXSID0044941 Css NA 0.2904 mg/L 3compartmentss NA 50% Human Human +DTXSID0044941 Css NA 2.373 mg/L 3compartmentss NA 95% Human Human +DTXSID0044941 Css NA 0.1864 mg/L PBTK NA 50% Human Human +DTXSID0044941 Css NA 1.439 mg/L PBTK NA 95% Human Human +DTXSID0044941 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044941 Fup 0.0965 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044941 Vd NA 0.6701 L/kg 1compartment NA NA Rat Human DTXSID0044941 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044941 TK.Half.Life NA 3.02 hours 1compartment NA NA Rat Human -DTXSID0044941 Css NA 0.4854 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044941 Css NA 2.287 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044941 Css NA 0.3032 mg/L PBTK NA 50% Rat Human -DTXSID0044941 Css NA 1.308 mg/L PBTK NA 95% Rat Human -DTXSID0044943 Clint NA 0.8194 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044943 Fup NA 0.7259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044943 Vd NA 1.998 L/kg 1compartment NA NA Human Human -DTXSID0044943 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044943 TK.Half.Life NA 7.896 hours 1compartment NA NA Human Human -DTXSID0044943 Css NA 0.3641 mg/L 3compartmentss NA 50% Human Human -DTXSID0044943 Css NA 2.876 mg/L 3compartmentss NA 95% Human Human -DTXSID0044943 Css NA 0.3644 mg/L PBTK NA 50% Human Human -DTXSID0044943 Css NA 1.982 mg/L PBTK NA 95% Human Human -DTXSID0044943 Clint NA 0.8194 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044943 Fup NA 0.7259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044943 Vd NA 2.028 L/kg 1compartment NA NA Rat Human +DTXSID0044941 TK.Half.Life NA 1.015 hours 1compartment NA NA Rat Human +DTXSID0044941 Css NA 0.0379 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044941 Css NA 0.2342 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044941 Css NA 0.02365 mg/L PBTK NA 50% Rat Human +DTXSID0044941 Css NA 0.1404 mg/L PBTK NA 95% Rat Human +DTXSID0044943 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044943 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044943 Vd NA 2.001 L/kg 1compartment NA NA Human Human +DTXSID0044943 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0044943 TK.Half.Life NA 18.25 hours 1compartment NA NA Human Human +DTXSID0044943 Css NA 0.8516 mg/L 3compartmentss NA 50% Human Human +DTXSID0044943 Css NA 6.353 mg/L 3compartmentss NA 95% Human Human +DTXSID0044943 Css NA 0.8527 mg/L PBTK NA 50% Human Human +DTXSID0044943 Css NA 4.285 mg/L PBTK NA 95% Human Human +DTXSID0044943 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044943 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044943 Vd NA 2.03 L/kg 1compartment NA NA Rat Human DTXSID0044943 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044943 TK.Half.Life NA 3.784 hours 1compartment NA NA Rat Human -DTXSID0044943 Css NA 0.1316 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044943 Css NA 0.9984 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044943 Css NA 0.1325 mg/L PBTK NA 50% Rat Human -DTXSID0044943 Css NA 0.6327 mg/L PBTK NA 95% Rat Human -DTXSID0044945 Clint NA 108.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044945 Fup NA 0.8316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044945 Vd NA 1.028 L/kg 1compartment NA NA Human Human +DTXSID0044943 TK.Half.Life NA 6.301 hours 1compartment NA NA Rat Human +DTXSID0044943 Css NA 0.04926 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044943 Css NA 0.3764 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044943 Css NA 0.05069 mg/L PBTK NA 50% Rat Human +DTXSID0044943 Css NA 0.247 mg/L PBTK NA 95% Rat Human +DTXSID0044945 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044945 Fup 0.52 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044945 Vd NA 0.7292 L/kg 1compartment NA NA Human Human DTXSID0044945 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044945 TK.Half.Life NA 0.6123 hours 1compartment NA NA Human Human -DTXSID0044945 Css NA 0.005513 mg/L 3compartmentss NA 50% Human Human -DTXSID0044945 Css NA 0.0632 mg/L 3compartmentss NA 95% Human Human -DTXSID0044945 Css NA 0.004684 mg/L PBTK NA 50% Human Human -DTXSID0044945 Css NA 0.04396 mg/L PBTK NA 95% Human Human -DTXSID0044945 Clint NA 108.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044945 Fup NA 0.8316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044945 Vd NA 0.9999 L/kg 1compartment NA NA Rat Human +DTXSID0044945 TK.Half.Life NA 9.17 hours 1compartment NA NA Human Human +DTXSID0044945 Css NA 1.347 mg/L 3compartmentss NA 50% Human Human +DTXSID0044945 Css NA 7.424 mg/L 3compartmentss NA 95% Human Human +DTXSID0044945 Css NA 1.067 mg/L PBTK NA 50% Human Human +DTXSID0044945 Css NA 4.751 mg/L PBTK NA 95% Human Human +DTXSID0044945 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044945 Fup 0.52 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044945 Vd NA 0.7167 L/kg 1compartment NA NA Rat Human DTXSID0044945 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044945 TK.Half.Life NA 0.2642 hours 1compartment NA NA Rat Human -DTXSID0044945 Css NA 0.002836 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044945 Css NA 0.02721 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044945 Css NA 0.002409 mg/L PBTK NA 50% Rat Human -DTXSID0044945 Css NA 0.01908 mg/L PBTK NA 95% Rat Human -DTXSID0044947 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044947 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044947 Vd NA 0.8894 L/kg 1compartment NA NA Human Human +DTXSID0044945 TK.Half.Life NA 3.045 hours 1compartment NA NA Rat Human +DTXSID0044945 Css NA 0.08382 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044945 Css NA 0.4276 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044945 Css NA 0.06574 mg/L PBTK NA 50% Rat Human +DTXSID0044945 Css NA 0.2631 mg/L PBTK NA 95% Rat Human +DTXSID0044947 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044947 Fup 0.842 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044947 Vd NA 0.773 L/kg 1compartment NA NA Human Human DTXSID0044947 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044947 TK.Half.Life NA 5.776 hours 1compartment NA NA Human Human -DTXSID0044947 Css NA 0.7986 mg/L 3compartmentss NA 50% Human Human -DTXSID0044947 Css NA 5.746 mg/L 3compartmentss NA 95% Human Human -DTXSID0044947 Css NA 0.6968 mg/L PBTK NA 50% Human Human -DTXSID0044947 Css NA 3.706 mg/L PBTK NA 95% Human Human -DTXSID0044947 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044947 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044947 Vd NA 0.9117 L/kg 1compartment NA NA Rat Human +DTXSID0044947 TK.Half.Life NA 5.95 hours 1compartment NA NA Human Human +DTXSID0044947 Css NA 0.9344 mg/L 3compartmentss NA 50% Human Human +DTXSID0044947 Css NA 5.548 mg/L 3compartmentss NA 95% Human Human +DTXSID0044947 Css NA 0.773 mg/L PBTK NA 50% Human Human +DTXSID0044947 Css NA 3.606 mg/L PBTK NA 95% Human Human +DTXSID0044947 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044947 Fup 0.842 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044947 Vd NA 0.7963 L/kg 1compartment NA NA Rat Human DTXSID0044947 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044947 TK.Half.Life NA 2.012 hours 1compartment NA NA Rat Human -DTXSID0044947 Css NA 0.2019 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044947 Css NA 1.239 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044947 Css NA 0.1723 mg/L PBTK NA 50% Rat Human -DTXSID0044947 Css NA 0.7575 mg/L PBTK NA 95% Rat Human -DTXSID0044949 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044949 Fup NA 0.825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044949 Vd NA 0.864 L/kg 1compartment NA NA Human Human +DTXSID0044947 TK.Half.Life NA 2.086 hours 1compartment NA NA Rat Human +DTXSID0044947 Css NA 0.05467 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044947 Css NA 0.3142 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044947 Css NA 0.04578 mg/L PBTK NA 50% Rat Human +DTXSID0044947 Css NA 0.196 mg/L PBTK NA 95% Rat Human +DTXSID0044949 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044949 Fup 0.796 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044949 Vd NA 0.8646 L/kg 1compartment NA NA Human Human DTXSID0044949 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044949 TK.Half.Life NA 6.829 hours 1compartment NA NA Human Human -DTXSID0044949 Css NA 0.9498 mg/L 3compartmentss NA 50% Human Human -DTXSID0044949 Css NA 5.645 mg/L 3compartmentss NA 95% Human Human -DTXSID0044949 Css NA 0.8064 mg/L PBTK NA 50% Human Human -DTXSID0044949 Css NA 3.703 mg/L PBTK NA 95% Human Human -DTXSID0044949 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044949 Fup NA 0.825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044949 Vd NA 0.8698 L/kg 1compartment NA NA Rat Human +DTXSID0044949 TK.Half.Life NA 7.09 hours 1compartment NA NA Human Human +DTXSID0044949 Css NA 0.9433 mg/L 3compartmentss NA 50% Human Human +DTXSID0044949 Css NA 6.018 mg/L 3compartmentss NA 95% Human Human +DTXSID0044949 Css NA 0.8005 mg/L PBTK NA 50% Human Human +DTXSID0044949 Css NA 3.883 mg/L PBTK NA 95% Human Human +DTXSID0044949 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044949 Fup 0.796 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044949 Vd NA 0.8663 L/kg 1compartment NA NA Rat Human DTXSID0044949 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044949 TK.Half.Life NA 2.328 hours 1compartment NA NA Rat Human -DTXSID0044949 Css NA 0.2413 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044949 Css NA 1.486 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044949 Css NA 0.1995 mg/L PBTK NA 50% Rat Human -DTXSID0044949 Css NA 0.8974 mg/L PBTK NA 95% Rat Human -DTXSID0044993 Clint NA 12.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044993 Fup NA 0.1377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044993 Vd NA 2.279 L/kg 1compartment NA NA Human Human +DTXSID0044949 TK.Half.Life NA 2.405 hours 1compartment NA NA Rat Human +DTXSID0044949 Css NA 0.05524 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044949 Css NA 0.336 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044949 Css NA 0.04725 mg/L PBTK NA 50% Rat Human +DTXSID0044949 Css NA 0.2104 mg/L PBTK NA 95% Rat Human +DTXSID0044993 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044993 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044993 Vd NA 1.302 L/kg 1compartment NA NA Human Human DTXSID0044993 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044993 TK.Half.Life NA 10.22 hours 1compartment NA NA Human Human -DTXSID0044993 Css NA 0.514 mg/L 3compartmentss NA 50% Human Human -DTXSID0044993 Css NA 3.382 mg/L 3compartmentss NA 95% Human Human -DTXSID0044993 Css NA 0.3585 mg/L PBTK NA 50% Human Human -DTXSID0044993 Css NA 2.214 mg/L PBTK NA 95% Human Human -DTXSID0044993 Clint NA 12.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044993 Fup NA 0.1377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044993 Vd NA 1.73 L/kg 1compartment NA NA Rat Human +DTXSID0044993 TK.Half.Life NA 2.705 hours 1compartment NA NA Human Human +DTXSID0044993 Css NA 0.1803 mg/L 3compartmentss NA 50% Human Human +DTXSID0044993 Css NA 1.363 mg/L 3compartmentss NA 95% Human Human +DTXSID0044993 Css NA 0.1225 mg/L PBTK NA 50% Human Human +DTXSID0044993 Css NA 0.872 mg/L PBTK NA 95% Human Human +DTXSID0044993 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044993 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044993 Vd NA 1.024 L/kg 1compartment NA NA Rat Human DTXSID0044993 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044993 TK.Half.Life NA 2.999 hours 1compartment NA NA Rat Human -DTXSID0044993 Css NA 0.2808 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044993 Css NA 1.385 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044993 Css NA 0.1864 mg/L PBTK NA 50% Rat Human -DTXSID0044993 Css NA 0.8704 mg/L PBTK NA 95% Rat Human -DTXSID0044995 Clint NA 6.252 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044995 Fup NA 0.035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044995 Vd NA 2.191 L/kg 1compartment NA NA Human Human -DTXSID0044995 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID0044995 TK.Half.Life NA 50.74 hours 1compartment NA NA Human Human -DTXSID0044995 Css NA 3.516 mg/L 3compartmentss NA 50% Human Human -DTXSID0044995 Css NA 21.18 mg/L 3compartmentss NA 95% Human Human -DTXSID0044995 Css NA 2.29 mg/L PBTK NA 50% Human Human -DTXSID0044995 Css NA 13.31 mg/L PBTK NA 95% Human Human -DTXSID0044995 Clint NA 6.252 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044995 Fup NA 0.035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044995 Vd NA 1.636 L/kg 1compartment NA NA Rat Human -DTXSID0044995 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0044995 TK.Half.Life NA 14.43 hours 1compartment NA NA Rat Human -DTXSID0044995 Css NA 1.89 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044995 Css NA 8.298 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044995 Css NA 1.171 mg/L PBTK NA 50% Rat Human -DTXSID0044995 Css NA 4.937 mg/L PBTK NA 95% Rat Human +DTXSID0044993 TK.Half.Life NA 1.105 hours 1compartment NA NA Rat Human +DTXSID0044993 Css NA 0.02312 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044993 Css NA 0.1435 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044993 Css NA 0.01559 mg/L PBTK NA 50% Rat Human +DTXSID0044993 Css NA 0.09005 mg/L PBTK NA 95% Rat Human +DTXSID0044995 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044995 Fup 0.0942 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044995 Vd NA 2.992 L/kg 1compartment NA NA Human Human +DTXSID0044995 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0044995 TK.Half.Life NA 29.41 hours 1compartment NA NA Human Human +DTXSID0044995 Css NA 1.125 mg/L 3compartmentss NA 50% Human Human +DTXSID0044995 Css NA 7.118 mg/L 3compartmentss NA 95% Human Human +DTXSID0044995 Css NA 0.7849 mg/L PBTK NA 50% Human Human +DTXSID0044995 Css NA 4.776 mg/L PBTK NA 95% Human Human +DTXSID0044995 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044995 Fup 0.0942 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044995 Vd NA 2.247 L/kg 1compartment NA NA Rat Human +DTXSID0044995 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0044995 TK.Half.Life NA 4.987 hours 1compartment NA NA Rat Human +DTXSID0044995 Css NA 0.1453 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044995 Css NA 0.7746 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044995 Css NA 0.1003 mg/L PBTK NA 50% Rat Human +DTXSID0044995 Css NA 0.5158 mg/L PBTK NA 95% Rat Human DTXSID0044997 Clint 1.55 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID0044997 Fup 0.2649 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID0044997 Vd NA 5.308 L/kg 1compartment NA NA Human Human -DTXSID0044997 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0044997 TK.Half.Life NA 31.42 hours 1compartment NA NA Human Human -DTXSID0044997 Css NA 0.3496 mg/L 3compartmentss NA 50% Human Human -DTXSID0044997 Css NA 1.712 mg/L 3compartmentss NA 95% Human Human -DTXSID0044997 Css NA 0.4916 mg/L PBTK NA 50% Human Human -DTXSID0044997 Css NA 1.952 mg/L PBTK NA 95% Human Human +DTXSID0044997 Vd NA 3.11 L/kg 1compartment NA NA Human Human +DTXSID0044997 Days.Css NA 88 Days PBTK NA NA Human Human +DTXSID0044997 TK.Half.Life NA 388.1 hours 1compartment NA NA Human Human +DTXSID0044997 Css NA 14.32 mg/L 3compartmentss NA 50% Human Human +DTXSID0044997 Css NA 64.75 mg/L 3compartmentss NA 95% Human Human +DTXSID0044997 Css NA 10.14 mg/L PBTK NA 50% Human Human +DTXSID0044997 Css NA 43.66 mg/L PBTK NA 95% Human Human DTXSID0044997 Clint 1.55 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID0044997 Fup 0.2649 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID0044997 Vd NA 5.206 L/kg 1compartment NA NA Rat Human -DTXSID0044997 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0044997 TK.Half.Life NA 13.57 hours 1compartment NA NA Rat Human -DTXSID0044997 Css NA 0.157 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044997 Css NA 0.573 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044997 Css NA 0.224 mg/L PBTK NA 50% Rat Human -DTXSID0044997 Css NA 0.6236 mg/L PBTK NA 95% Rat Human -DTXSID0044999 Clint NA 0.6853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044999 Fup NA 0.2597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0044999 Vd NA 0.4964 L/kg 1compartment NA NA Human Human +DTXSID0044997 Vd NA 2.337 L/kg 1compartment NA NA Rat Human +DTXSID0044997 Days.Css NA 42 Days PBTK NA NA Rat Human +DTXSID0044997 TK.Half.Life NA 46.9 hours 1compartment NA NA Rat Human +DTXSID0044997 Css NA 1.658 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044997 Css NA 5.218 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044997 Css NA 1.165 mg/L PBTK NA 50% Rat Human +DTXSID0044997 Css NA 3.457 mg/L PBTK NA 95% Rat Human +DTXSID0044999 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044999 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0044999 Vd NA 0.3732 L/kg 1compartment NA NA Human Human DTXSID0044999 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0044999 TK.Half.Life NA 5.869 hours 1compartment NA NA Human Human -DTXSID0044999 Css NA 1.316 mg/L 3compartmentss NA 50% Human Human -DTXSID0044999 Css NA 5.658 mg/L 3compartmentss NA 95% Human Human -DTXSID0044999 Css NA 0.9341 mg/L PBTK NA 50% Human Human -DTXSID0044999 Css NA 3.62 mg/L PBTK NA 95% Human Human -DTXSID0044999 Clint NA 0.6853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044999 Fup NA 0.2597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0044999 Vd NA 0.4996 L/kg 1compartment NA NA Rat Human +DTXSID0044999 TK.Half.Life NA 7.522 hours 1compartment NA NA Human Human +DTXSID0044999 Css NA 2.348 mg/L 3compartmentss NA 50% Human Human +DTXSID0044999 Css NA 9.244 mg/L 3compartmentss NA 95% Human Human +DTXSID0044999 Css NA 1.604 mg/L PBTK NA 50% Human Human +DTXSID0044999 Css NA 5.74 mg/L PBTK NA 95% Human Human +DTXSID0044999 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044999 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0044999 Vd NA 0.3952 L/kg 1compartment NA NA Rat Human DTXSID0044999 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0044999 TK.Half.Life NA 2.746 hours 1compartment NA NA Rat Human -DTXSID0044999 Css NA 0.5074 mg/L 3compartmentss NA 50% Rat Human -DTXSID0044999 Css NA 1.822 mg/L 3compartmentss NA 95% Rat Human -DTXSID0044999 Css NA 0.3436 mg/L PBTK NA 50% Rat Human -DTXSID0044999 Css NA 1.072 mg/L PBTK NA 95% Rat Human -DTXSID0045090 Clint NA 19.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045090 Fup NA 0.116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045090 Vd NA 2.755 L/kg 1compartment NA NA Human Human +DTXSID0044999 TK.Half.Life NA 2.715 hours 1compartment NA NA Rat Human +DTXSID0044999 Css NA 0.1524 mg/L 3compartmentss NA 50% Rat Human +DTXSID0044999 Css NA 0.4976 mg/L 3compartmentss NA 95% Rat Human +DTXSID0044999 Css NA 0.1019 mg/L PBTK NA 50% Rat Human +DTXSID0044999 Css NA 0.297 mg/L PBTK NA 95% Rat Human +DTXSID0045090 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045090 Fup 0.096 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045090 Vd NA 2.842 L/kg 1compartment NA NA Human Human DTXSID0045090 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045090 TK.Half.Life NA 4.906 hours 1compartment NA NA Human Human -DTXSID0045090 Css NA 0.142 mg/L 3compartmentss NA 50% Human Human -DTXSID0045090 Css NA 1.29 mg/L 3compartmentss NA 95% Human Human -DTXSID0045090 Css NA 0.1272 mg/L PBTK NA 50% Human Human -DTXSID0045090 Css NA 0.9777 mg/L PBTK NA 95% Human Human -DTXSID0045090 Clint NA 19.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045090 Fup NA 0.116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045090 Vd NA 2.704 L/kg 1compartment NA NA Rat Human +DTXSID0045090 TK.Half.Life NA 4.909 hours 1compartment NA NA Human Human +DTXSID0045090 Css NA 0.1312 mg/L 3compartmentss NA 50% Human Human +DTXSID0045090 Css NA 1.235 mg/L 3compartmentss NA 95% Human Human +DTXSID0045090 Css NA 0.1166 mg/L PBTK NA 50% Human Human +DTXSID0045090 Css NA 0.9314 mg/L PBTK NA 95% Human Human +DTXSID0045090 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045090 Fup 0.096 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045090 Vd NA 2.74 L/kg 1compartment NA NA Rat Human DTXSID0045090 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045090 TK.Half.Life NA 2.751 hours 1compartment NA NA Rat Human -DTXSID0045090 Css NA 0.07767 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045090 Css NA 0.5493 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045090 Css NA 0.06773 mg/L PBTK NA 50% Rat Human -DTXSID0045090 Css NA 0.3914 mg/L PBTK NA 95% Rat Human -DTXSID0045094 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045094 Fup NA 0.0991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045094 Vd NA 0.2844 L/kg 1compartment NA NA Human Human -DTXSID0045094 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0045094 TK.Half.Life NA 18.6 hours 1compartment NA NA Human Human -DTXSID0045094 Css NA 10.25 mg/L 3compartmentss NA 50% Human Human -DTXSID0045094 Css NA 45.32 mg/L 3compartmentss NA 95% Human Human -DTXSID0045094 Css NA 6.329 mg/L PBTK NA 50% Human Human -DTXSID0045094 Css NA 26.65 mg/L PBTK NA 95% Human Human -DTXSID0045094 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045094 Fup NA 0.0991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045094 Vd NA 0.2755 L/kg 1compartment NA NA Rat Human +DTXSID0045090 TK.Half.Life NA 2.613 hours 1compartment NA NA Rat Human +DTXSID0045090 Css NA 0.0169 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045090 Css NA 0.127 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045090 Css NA 0.01497 mg/L PBTK NA 50% Rat Human +DTXSID0045090 Css NA 0.09338 mg/L PBTK NA 95% Rat Human +DTXSID0045094 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045094 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045094 Vd NA 0.283 L/kg 1compartment NA NA Human Human +DTXSID0045094 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0045094 TK.Half.Life NA 9.486 hours 1compartment NA NA Human Human +DTXSID0045094 Css NA 3.614 mg/L 3compartmentss NA 50% Human Human +DTXSID0045094 Css NA 13.25 mg/L 3compartmentss NA 95% Human Human +DTXSID0045094 Css NA 2.296 mg/L PBTK NA 50% Human Human +DTXSID0045094 Css NA 8.071 mg/L PBTK NA 95% Human Human +DTXSID0045094 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045094 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045094 Vd NA 0.2847 L/kg 1compartment NA NA Rat Human DTXSID0045094 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045094 TK.Half.Life NA 6.129 hours 1compartment NA NA Rat Human -DTXSID0045094 Css NA 2.884 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045094 Css NA 11.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045094 Css NA 1.662 mg/L PBTK NA 50% Rat Human -DTXSID0045094 Css NA 6.164 mg/L PBTK NA 95% Rat Human -DTXSID0045096 Clint NA 7.361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045096 Fup NA 0.1197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045096 Vd NA 3.492 L/kg 1compartment NA NA Human Human +DTXSID0045094 TK.Half.Life NA 3.253 hours 1compartment NA NA Rat Human +DTXSID0045094 Css NA 0.08976 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045094 Css NA 0.4553 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045094 Css NA 0.0552 mg/L PBTK NA 50% Rat Human +DTXSID0045094 Css NA 0.2669 mg/L PBTK NA 95% Rat Human +DTXSID0045096 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045096 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045096 Vd NA 0.6381 L/kg 1compartment NA NA Human Human DTXSID0045096 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045096 TK.Half.Life NA 11.17 hours 1compartment NA NA Human Human -DTXSID0045096 Css NA 0.2876 mg/L 3compartmentss NA 50% Human Human -DTXSID0045096 Css NA 2.384 mg/L 3compartmentss NA 95% Human Human -DTXSID0045096 Css NA 0.2766 mg/L PBTK NA 50% Human Human -DTXSID0045096 Css NA 1.886 mg/L PBTK NA 95% Human Human -DTXSID0045096 Clint NA 7.361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045096 Fup NA 0.1197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045096 Vd NA 3.317 L/kg 1compartment NA NA Rat Human +DTXSID0045096 TK.Half.Life NA 1.157 hours 1compartment NA NA Human Human +DTXSID0045096 Css NA 0.1258 mg/L 3compartmentss NA 50% Human Human +DTXSID0045096 Css NA 0.9171 mg/L 3compartmentss NA 95% Human Human +DTXSID0045096 Css NA 0.08594 mg/L PBTK NA 50% Human Human +DTXSID0045096 Css NA 0.588 mg/L PBTK NA 95% Human Human +DTXSID0045096 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045096 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045096 Vd NA 0.6418 L/kg 1compartment NA NA Rat Human DTXSID0045096 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045096 TK.Half.Life NA 5.484 hours 1compartment NA NA Rat Human -DTXSID0045096 Css NA 0.1532 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045096 Css NA 0.9512 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045096 Css NA 0.1428 mg/L PBTK NA 50% Rat Human -DTXSID0045096 Css NA 0.7229 mg/L PBTK NA 95% Rat Human -DTXSID0045125 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045125 Fup NA 0.0685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045125 Vd NA 2.848 L/kg 1compartment NA NA Human Human -DTXSID0045125 Days.Css NA 483 Days PBTK NA NA Human Human -DTXSID0045125 TK.Half.Life NA 1825 hours 1compartment NA NA Human Human -DTXSID0045125 Css NA 78.74 mg/L 3compartmentss NA 50% Human Human -DTXSID0045125 Css NA 231.1 mg/L 3compartmentss NA 95% Human Human -DTXSID0045125 Css NA 54.37 mg/L PBTK NA 50% Human Human -DTXSID0045125 Css NA 148.6 mg/L PBTK NA 95% Human Human -DTXSID0045125 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045125 Fup NA 0.0685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045125 Vd NA 2.135 L/kg 1compartment NA NA Rat Human -DTXSID0045125 Days.Css NA 119 Days PBTK NA NA Rat Human -DTXSID0045125 TK.Half.Life NA 163.5 hours 1compartment NA NA Rat Human -DTXSID0045125 Css NA 21.53 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045125 Css NA 49.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045125 Css NA 14.16 mg/L PBTK NA 50% Rat Human -DTXSID0045125 Css NA 29.73 mg/L PBTK NA 95% Rat Human +DTXSID0045096 TK.Half.Life NA 0.6595 hours 1compartment NA NA Rat Human +DTXSID0045096 Css NA 0.01617 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045096 Css NA 0.08635 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045096 Css NA 0.0108 mg/L PBTK NA 50% Rat Human +DTXSID0045096 Css NA 0.05467 mg/L PBTK NA 95% Rat Human +DTXSID0045125 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045125 Fup 0.0437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045125 Vd NA 2.047 L/kg 1compartment NA NA Human Human +DTXSID0045125 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0045125 TK.Half.Life NA 12.52 hours 1compartment NA NA Human Human +DTXSID0045125 Css NA 0.8185 mg/L 3compartmentss NA 50% Human Human +DTXSID0045125 Css NA 6.177 mg/L 3compartmentss NA 95% Human Human +DTXSID0045125 Css NA 0.5345 mg/L PBTK NA 50% Human Human +DTXSID0045125 Css NA 3.874 mg/L PBTK NA 95% Human Human +DTXSID0045125 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045125 Fup 0.0437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045125 Vd NA 1.528 L/kg 1compartment NA NA Rat Human +DTXSID0045125 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0045125 TK.Half.Life NA 3.963 hours 1compartment NA NA Rat Human +DTXSID0045125 Css NA 0.1056 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045125 Css NA 0.6581 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045125 Css NA 0.06785 mg/L PBTK NA 50% Rat Human +DTXSID0045125 Css NA 0.4026 mg/L PBTK NA 95% Rat Human DTXSID0045127 Clint 22.98 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID0045127 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID0045127 Vd NA 9.399 L/kg 1compartment NA NA Human Human DTXSID0045127 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0045127 TK.Half.Life NA 2.9 hours 1compartment NA NA Human Human -DTXSID0045127 Css NA 0.00626 mg/L 3compartmentss NA 50% Human Human -DTXSID0045127 Css NA 0.1207 mg/L 3compartmentss NA 95% Human Human -DTXSID0045127 Css NA 0.01532 mg/L PBTK NA 50% Human Human -DTXSID0045127 Css NA 0.1781 mg/L PBTK NA 95% Human Human +DTXSID0045127 Css NA 0.005372 mg/L 3compartmentss NA 50% Human Human +DTXSID0045127 Css NA 0.11 mg/L 3compartmentss NA 95% Human Human +DTXSID0045127 Css NA 0.0132 mg/L PBTK NA 50% Human Human +DTXSID0045127 Css NA 0.1636 mg/L PBTK NA 95% Human Human DTXSID0045127 Clint 22.98 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID0045127 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID0045127 Vd NA 9.675 L/kg 1compartment NA NA Rat Human DTXSID0045127 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0045127 TK.Half.Life NA 1.553 hours 1compartment NA NA Rat Human -DTXSID0045127 Css NA 0.00293 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045127 Css NA 0.04772 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045127 Css NA 0.007755 mg/L PBTK NA 50% Rat Human -DTXSID0045127 Css NA 0.06813 mg/L PBTK NA 95% Rat Human -DTXSID0045171 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0045127 Css NA 0.000597 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045127 Css NA 0.01044 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045127 Css NA 0.001655 mg/L PBTK NA 50% Rat Human +DTXSID0045127 Css NA 0.01548 mg/L PBTK NA 95% Rat Human +DTXSID0045171 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0045171 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0045171 Vd NA 0.5233 L/kg 1compartment NA NA Human Human +DTXSID0045171 Vd NA 0.5346 L/kg 1compartment NA NA Human Human DTXSID0045171 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045171 TK.Half.Life NA 0.6307 hours 1compartment NA NA Human Human -DTXSID0045171 Css NA 0.1044 mg/L 3compartmentss NA 50% Human Human -DTXSID0045171 Css NA 0.9043 mg/L 3compartmentss NA 95% Human Human -DTXSID0045171 Css NA 0.078 mg/L PBTK NA 50% Human Human -DTXSID0045171 Css NA 0.6082 mg/L PBTK NA 95% Human Human -DTXSID0045171 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0045171 TK.Half.Life NA 3.461 hours 1compartment NA NA Human Human +DTXSID0045171 Css NA 0.8762 mg/L 3compartmentss NA 50% Human Human +DTXSID0045171 Css NA 5.718 mg/L 3compartmentss NA 95% Human Human +DTXSID0045171 Css NA 0.6743 mg/L PBTK NA 50% Human Human +DTXSID0045171 Css NA 3.677 mg/L PBTK NA 95% Human Human +DTXSID0045171 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0045171 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0045171 Vd NA 0.5454 L/kg 1compartment NA NA Rat Human +DTXSID0045171 Vd NA 0.5555 L/kg 1compartment NA NA Rat Human DTXSID0045171 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045171 TK.Half.Life NA 0.337 hours 1compartment NA NA Rat Human -DTXSID0045171 Css NA 0.0488 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045171 Css NA 0.3283 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045171 Css NA 0.03598 mg/L PBTK NA 50% Rat Human -DTXSID0045171 Css NA 0.2012 mg/L PBTK NA 95% Rat Human -DTXSID0045173 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045173 Fup NA 0.6529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045173 Vd NA 1.122 L/kg 1compartment NA NA Human Human -DTXSID0045173 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0045173 TK.Half.Life NA 11.18 hours 1compartment NA NA Human Human -DTXSID0045173 Css NA 1.068 mg/L 3compartmentss NA 50% Human Human -DTXSID0045173 Css NA 7.48 mg/L 3compartmentss NA 95% Human Human -DTXSID0045173 Css NA 0.9193 mg/L PBTK NA 50% Human Human -DTXSID0045173 Css NA 4.863 mg/L PBTK NA 95% Human Human -DTXSID0045173 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045173 Fup NA 0.6529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045173 Vd NA 1.126 L/kg 1compartment NA NA Rat Human +DTXSID0045171 TK.Half.Life NA 1.225 hours 1compartment NA NA Rat Human +DTXSID0045171 Css NA 0.05184 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045171 Css NA 0.2974 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045171 Css NA 0.03996 mg/L PBTK NA 50% Rat Human +DTXSID0045171 Css NA 0.1803 mg/L PBTK NA 95% Rat Human +DTXSID0045173 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045173 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045173 Vd NA 0.9829 L/kg 1compartment NA NA Human Human +DTXSID0045173 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0045173 TK.Half.Life NA 20.51 hours 1compartment NA NA Human Human +DTXSID0045173 Css NA 1.188 mg/L 3compartmentss NA 50% Human Human +DTXSID0045173 Css NA 5.238 mg/L 3compartmentss NA 95% Human Human +DTXSID0045173 Css NA 0.9162 mg/L PBTK NA 50% Human Human +DTXSID0045173 Css NA 3.477 mg/L PBTK NA 95% Human Human +DTXSID0045173 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045173 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045173 Vd NA 0.9906 L/kg 1compartment NA NA Rat Human DTXSID0045173 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045173 TK.Half.Life NA 3.806 hours 1compartment NA NA Rat Human -DTXSID0045173 Css NA 0.2828 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045173 Css NA 1.783 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045173 Css NA 0.2341 mg/L PBTK NA 50% Rat Human -DTXSID0045173 Css NA 1.075 mg/L PBTK NA 95% Rat Human -DTXSID0045175 Clint NA 171.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045175 Fup NA 0.1944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045175 Vd NA 1.857 L/kg 1compartment NA NA Human Human +DTXSID0045173 TK.Half.Life NA 7.046 hours 1compartment NA NA Rat Human +DTXSID0045173 Css NA 0.006387 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045173 Css NA 0.02909 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045173 Css NA 0.004705 mg/L PBTK NA 50% Rat Human +DTXSID0045173 Css NA 0.01834 mg/L PBTK NA 95% Rat Human +DTXSID0045175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045175 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045175 Vd NA 2.004 L/kg 1compartment NA NA Human Human DTXSID0045175 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045175 TK.Half.Life NA 1.218 hours 1compartment NA NA Human Human -DTXSID0045175 Css NA 0.007766 mg/L 3compartmentss NA 50% Human Human -DTXSID0045175 Css NA 0.06667 mg/L 3compartmentss NA 95% Human Human -DTXSID0045175 Css NA 0.007308 mg/L PBTK NA 50% Human Human -DTXSID0045175 Css NA 0.05409 mg/L PBTK NA 95% Human Human -DTXSID0045175 Clint NA 171.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045175 Fup NA 0.1944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045175 Vd NA 1.818 L/kg 1compartment NA NA Rat Human +DTXSID0045175 TK.Half.Life NA 2.227 hours 1compartment NA NA Human Human +DTXSID0045175 Css NA 0.04965 mg/L 3compartmentss NA 50% Human Human +DTXSID0045175 Css NA 0.3983 mg/L 3compartmentss NA 95% Human Human +DTXSID0045175 Css NA 0.04891 mg/L PBTK NA 50% Human Human +DTXSID0045175 Css NA 0.3343 mg/L PBTK NA 95% Human Human +DTXSID0045175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045175 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045175 Vd NA 1.964 L/kg 1compartment NA NA Rat Human DTXSID0045175 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045175 TK.Half.Life NA 0.5585 hours 1compartment NA NA Rat Human -DTXSID0045175 Css NA 0.00421 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045175 Css NA 0.0283 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045175 Css NA 0.003959 mg/L PBTK NA 50% Rat Human -DTXSID0045175 Css NA 0.02293 mg/L PBTK NA 95% Rat Human -DTXSID0045179 Clint NA 1.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045179 Fup NA 0.4569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045179 Vd NA 0.656 L/kg 1compartment NA NA Human Human +DTXSID0045175 TK.Half.Life NA 1.221 hours 1compartment NA NA Rat Human +DTXSID0045175 Css NA 0.006079 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045175 Css NA 0.03899 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045175 Css NA 0.00615 mg/L PBTK NA 50% Rat Human +DTXSID0045175 Css NA 0.03238 mg/L PBTK NA 95% Rat Human +DTXSID0045179 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045179 Fup 0.597 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045179 Vd NA 0.7548 L/kg 1compartment NA NA Human Human DTXSID0045179 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045179 TK.Half.Life NA 2.629 hours 1compartment NA NA Human Human -DTXSID0045179 Css NA 0.4112 mg/L 3compartmentss NA 50% Human Human -DTXSID0045179 Css NA 2.386 mg/L 3compartmentss NA 95% Human Human -DTXSID0045179 Css NA 0.3129 mg/L PBTK NA 50% Human Human -DTXSID0045179 Css NA 1.555 mg/L PBTK NA 95% Human Human -DTXSID0045179 Clint NA 1.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045179 Fup NA 0.4569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045179 Vd NA 0.6474 L/kg 1compartment NA NA Rat Human +DTXSID0045179 TK.Half.Life NA 0.6863 hours 1compartment NA NA Human Human +DTXSID0045179 Css NA 0.03365 mg/L 3compartmentss NA 50% Human Human +DTXSID0045179 Css NA 0.3423 mg/L 3compartmentss NA 95% Human Human +DTXSID0045179 Css NA 0.02685 mg/L PBTK NA 50% Human Human +DTXSID0045179 Css NA 0.2343 mg/L PBTK NA 95% Human Human +DTXSID0045179 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045179 Fup 0.597 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045179 Vd NA 0.7464 L/kg 1compartment NA NA Rat Human DTXSID0045179 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045179 TK.Half.Life NA 1.356 hours 1compartment NA NA Rat Human -DTXSID0045179 Css NA 0.1773 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045179 Css NA 0.8634 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045179 Css NA 0.1305 mg/L PBTK NA 50% Rat Human -DTXSID0045179 Css NA 0.5199 mg/L PBTK NA 95% Rat Human -DTXSID0045202 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045202 Fup NA 0.362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045202 Vd NA 1.086 L/kg 1compartment NA NA Human Human +DTXSID0045179 TK.Half.Life NA 0.3363 hours 1compartment NA NA Rat Human +DTXSID0045179 Css NA 0.004051 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045179 Css NA 0.03803 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045179 Css NA 0.003256 mg/L PBTK NA 50% Rat Human +DTXSID0045179 Css NA 0.0249 mg/L PBTK NA 95% Rat Human +DTXSID0045202 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045202 Fup 0.435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045202 Vd NA 1.099 L/kg 1compartment NA NA Human Human DTXSID0045202 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045202 TK.Half.Life NA 1.345 hours 1compartment NA NA Human Human -DTXSID0045202 Css NA 0.06601 mg/L 3compartmentss NA 50% Human Human -DTXSID0045202 Css NA 0.5134 mg/L 3compartmentss NA 95% Human Human -DTXSID0045202 Css NA 0.05177 mg/L PBTK NA 50% Human Human -DTXSID0045202 Css NA 0.3529 mg/L PBTK NA 95% Human Human -DTXSID0045202 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045202 Fup NA 0.362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045202 Vd NA 1.016 L/kg 1compartment NA NA Rat Human +DTXSID0045202 TK.Half.Life NA 1.168 hours 1compartment NA NA Human Human +DTXSID0045202 Css NA 0.04436 mg/L 3compartmentss NA 50% Human Human +DTXSID0045202 Css NA 0.3613 mg/L 3compartmentss NA 95% Human Human +DTXSID0045202 Css NA 0.03557 mg/L PBTK NA 50% Human Human +DTXSID0045202 Css NA 0.2587 mg/L PBTK NA 95% Human Human +DTXSID0045202 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045202 Fup 0.435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045202 Vd NA 0.9672 L/kg 1compartment NA NA Rat Human DTXSID0045202 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045202 TK.Half.Life NA 0.662 hours 1compartment NA NA Rat Human -DTXSID0045202 Css NA 0.03527 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045202 Css NA 0.2192 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045202 Css NA 0.02655 mg/L PBTK NA 50% Rat Human -DTXSID0045202 Css NA 0.1415 mg/L PBTK NA 95% Rat Human -DTXSID0045204 Clint NA 909.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045204 Fup NA 0.7526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045204 Vd NA 3.844 L/kg 1compartment NA NA Human Human -DTXSID0045204 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045204 TK.Half.Life NA 2.293 hours 1compartment NA NA Human Human -DTXSID0045204 Css NA 0.002322 mg/L 3compartmentss NA 50% Human Human -DTXSID0045204 Css NA 0.01684 mg/L 3compartmentss NA 95% Human Human -DTXSID0045204 Css NA 0.002166 mg/L PBTK NA 50% Human Human -DTXSID0045204 Css NA 0.01391 mg/L PBTK NA 95% Human Human -DTXSID0045204 Clint NA 909.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045204 Fup NA 0.7526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045204 Vd NA 3.272 L/kg 1compartment NA NA Rat Human -DTXSID0045204 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045204 TK.Half.Life NA 0.8185 hours 1compartment NA NA Rat Human -DTXSID0045204 Css NA 0.00123 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045204 Css NA 0.00877 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045204 Css NA 0.001139 mg/L PBTK NA 50% Rat Human -DTXSID0045204 Css NA 0.006902 mg/L PBTK NA 95% Rat Human -DTXSID0045206 Clint NA 0.6335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045206 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045206 Vd NA 0.619 L/kg 1compartment NA NA Human Human +DTXSID0045202 TK.Half.Life NA 0.5161 hours 1compartment NA NA Rat Human +DTXSID0045202 Css NA 0.005457 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045202 Css NA 0.03729 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045202 Css NA 0.004389 mg/L PBTK NA 50% Rat Human +DTXSID0045202 Css NA 0.02573 mg/L PBTK NA 95% Rat Human +DTXSID0045204 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045204 Fup 0.0839 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045204 Vd NA 2.969 L/kg 1compartment NA NA Human Human +DTXSID0045204 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0045204 TK.Half.Life NA 29.14 hours 1compartment NA NA Human Human +DTXSID0045204 Css NA 1.13 mg/L 3compartmentss NA 50% Human Human +DTXSID0045204 Css NA 7.322 mg/L 3compartmentss NA 95% Human Human +DTXSID0045204 Css NA 0.7844 mg/L PBTK NA 50% Human Human +DTXSID0045204 Css NA 4.949 mg/L PBTK NA 95% Human Human +DTXSID0045204 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045204 Fup 0.0839 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045204 Vd NA 2.228 L/kg 1compartment NA NA Rat Human +DTXSID0045204 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0045204 TK.Half.Life NA 5.056 hours 1compartment NA NA Rat Human +DTXSID0045204 Css NA 0.1476 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045204 Css NA 0.7546 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045204 Css NA 0.1011 mg/L PBTK NA 50% Rat Human +DTXSID0045204 Css NA 0.5078 mg/L PBTK NA 95% Rat Human +DTXSID0045206 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045206 Fup 0.757 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045206 Vd NA 0.6483 L/kg 1compartment NA NA Human Human DTXSID0045206 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045206 TK.Half.Life NA 2.057 hours 1compartment NA NA Human Human -DTXSID0045206 Css NA 0.4325 mg/L 3compartmentss NA 50% Human Human -DTXSID0045206 Css NA 2.77 mg/L 3compartmentss NA 95% Human Human -DTXSID0045206 Css NA 0.3383 mg/L PBTK NA 50% Human Human -DTXSID0045206 Css NA 1.744 mg/L PBTK NA 95% Human Human -DTXSID0045206 Clint NA 0.6335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045206 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045206 Vd NA 0.6408 L/kg 1compartment NA NA Rat Human +DTXSID0045206 TK.Half.Life NA 5.541 hours 1compartment NA NA Human Human +DTXSID0045206 Css NA 1.019 mg/L 3compartmentss NA 50% Human Human +DTXSID0045206 Css NA 6.075 mg/L 3compartmentss NA 95% Human Human +DTXSID0045206 Css NA 0.8185 mg/L PBTK NA 50% Human Human +DTXSID0045206 Css NA 3.922 mg/L PBTK NA 95% Human Human +DTXSID0045206 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045206 Fup 0.757 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045206 Vd NA 0.6748 L/kg 1compartment NA NA Rat Human DTXSID0045206 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045206 TK.Half.Life NA 0.9565 hours 1compartment NA NA Rat Human -DTXSID0045206 Css NA 0.1508 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045206 Css NA 0.8994 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045206 Css NA 0.1153 mg/L PBTK NA 50% Rat Human -DTXSID0045206 Css NA 0.5324 mg/L PBTK NA 95% Rat Human -DTXSID0045208 Clint NA 22.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045208 Fup NA 0.0363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045208 Vd NA 0.8901 L/kg 1compartment NA NA Human Human +DTXSID0045206 TK.Half.Life NA 1.965 hours 1compartment NA NA Rat Human +DTXSID0045206 Css NA 0.05989 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045206 Css NA 0.3771 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045206 Css NA 0.04858 mg/L PBTK NA 50% Rat Human +DTXSID0045206 Css NA 0.231 mg/L PBTK NA 95% Rat Human +DTXSID0045208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045208 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045208 Vd NA 2.359 L/kg 1compartment NA NA Human Human DTXSID0045208 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045208 TK.Half.Life NA 3.986 hours 1compartment NA NA Human Human -DTXSID0045208 Css NA 0.6592 mg/L 3compartmentss NA 50% Human Human -DTXSID0045208 Css NA 5.722 mg/L 3compartmentss NA 95% Human Human -DTXSID0045208 Css NA 0.4274 mg/L PBTK NA 50% Human Human -DTXSID0045208 Css NA 3.585 mg/L PBTK NA 95% Human Human -DTXSID0045208 Clint NA 22.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045208 Fup NA 0.0363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045208 Vd NA 0.8678 L/kg 1compartment NA NA Rat Human +DTXSID0045208 TK.Half.Life NA 3.705 hours 1compartment NA NA Human Human +DTXSID0045208 Css NA 0.1118 mg/L 3compartmentss NA 50% Human Human +DTXSID0045208 Css NA 1.119 mg/L 3compartmentss NA 95% Human Human +DTXSID0045208 Css NA 0.09992 mg/L PBTK NA 50% Human Human +DTXSID0045208 Css NA 0.8083 mg/L PBTK NA 95% Human Human +DTXSID0045208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045208 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045208 Vd NA 2.353 L/kg 1compartment NA NA Rat Human DTXSID0045208 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045208 TK.Half.Life NA 2.477 hours 1compartment NA NA Rat Human -DTXSID0045208 Css NA 0.3837 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045208 Css NA 2.441 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045208 Css NA 0.2336 mg/L PBTK NA 50% Rat Human -DTXSID0045208 Css NA 1.4 mg/L PBTK NA 95% Rat Human -DTXSID0045250 Clint NA 0.779 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045250 Fup NA 0.8688 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045250 Vd NA 1.109 L/kg 1compartment NA NA Human Human +DTXSID0045208 TK.Half.Life NA 2.169 hours 1compartment NA NA Rat Human +DTXSID0045208 Css NA 0.01429 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045208 Css NA 0.1117 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045208 Css NA 0.0128 mg/L PBTK NA 50% Rat Human +DTXSID0045208 Css NA 0.07913 mg/L PBTK NA 95% Rat Human +DTXSID0045250 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045250 Fup 0.629 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045250 Vd NA 0.9049 L/kg 1compartment NA NA Human Human DTXSID0045250 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045250 TK.Half.Life NA 3.925 hours 1compartment NA NA Human Human -DTXSID0045250 Css NA 0.3961 mg/L 3compartmentss NA 50% Human Human -DTXSID0045250 Css NA 2.543 mg/L 3compartmentss NA 95% Human Human -DTXSID0045250 Css NA 0.3461 mg/L PBTK NA 50% Human Human -DTXSID0045250 Css NA 1.686 mg/L PBTK NA 95% Human Human -DTXSID0045250 Clint NA 0.779 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045250 Fup NA 0.8688 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045250 Vd NA 1.058 L/kg 1compartment NA NA Rat Human +DTXSID0045250 TK.Half.Life NA 9.563 hours 1compartment NA NA Human Human +DTXSID0045250 Css NA 1.124 mg/L 3compartmentss NA 50% Human Human +DTXSID0045250 Css NA 7.793 mg/L 3compartmentss NA 95% Human Human +DTXSID0045250 Css NA 0.9348 mg/L PBTK NA 50% Human Human +DTXSID0045250 Css NA 4.969 mg/L PBTK NA 95% Human Human +DTXSID0045250 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045250 Fup 0.629 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045250 Vd NA 0.8623 L/kg 1compartment NA NA Rat Human DTXSID0045250 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045250 TK.Half.Life NA 1.699 hours 1compartment NA NA Rat Human -DTXSID0045250 Css NA 0.1401 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045250 Css NA 0.8061 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045250 Css NA 0.1222 mg/L PBTK NA 50% Rat Human -DTXSID0045250 Css NA 0.5022 mg/L PBTK NA 95% Rat Human -DTXSID0045252 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045252 Fup NA 0.3163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045252 Vd NA 0.3634 L/kg 1compartment NA NA Human Human +DTXSID0045250 TK.Half.Life NA 3.041 hours 1compartment NA NA Rat Human +DTXSID0045250 Css NA 0.06881 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045250 Css NA 0.4401 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045250 Css NA 0.05696 mg/L PBTK NA 50% Rat Human +DTXSID0045250 Css NA 0.2712 mg/L PBTK NA 95% Rat Human +DTXSID0045252 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045252 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045252 Vd NA 0.465 L/kg 1compartment NA NA Human Human DTXSID0045252 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045252 TK.Half.Life NA 7.435 hours 1compartment NA NA Human Human -DTXSID0045252 Css NA 2.481 mg/L 3compartmentss NA 50% Human Human -DTXSID0045252 Css NA 10.06 mg/L 3compartmentss NA 95% Human Human -DTXSID0045252 Css NA 1.662 mg/L PBTK NA 50% Human Human -DTXSID0045252 Css NA 6.093 mg/L PBTK NA 95% Human Human -DTXSID0045252 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045252 Fup NA 0.3163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045252 Vd NA 0.3756 L/kg 1compartment NA NA Rat Human +DTXSID0045252 TK.Half.Life NA 6.406 hours 1compartment NA NA Human Human +DTXSID0045252 Css NA 0.862 mg/L 3compartmentss NA 50% Human Human +DTXSID0045252 Css NA 4.276 mg/L 3compartmentss NA 95% Human Human +DTXSID0045252 Css NA 0.6245 mg/L PBTK NA 50% Human Human +DTXSID0045252 Css NA 2.653 mg/L PBTK NA 95% Human Human +DTXSID0045252 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045252 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045252 Vd NA 0.4782 L/kg 1compartment NA NA Rat Human DTXSID0045252 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045252 TK.Half.Life NA 2.619 hours 1compartment NA NA Rat Human -DTXSID0045252 Css NA 0.6979 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045252 Css NA 2.278 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045252 Css NA 0.443 mg/L PBTK NA 50% Rat Human -DTXSID0045252 Css NA 1.303 mg/L PBTK NA 95% Rat Human -DTXSID0045254 Clint NA 16.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045254 Fup NA 0.0981 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045254 Vd NA 1.702 L/kg 1compartment NA NA Human Human +DTXSID0045252 TK.Half.Life NA 2.244 hours 1compartment NA NA Rat Human +DTXSID0045252 Css NA 0.004704 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045252 Css NA 0.02379 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045252 Css NA 0.003226 mg/L PBTK NA 50% Rat Human +DTXSID0045252 Css NA 0.01432 mg/L PBTK NA 95% Rat Human +DTXSID0045254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045254 Fup 0.0893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045254 Vd NA 1.637 L/kg 1compartment NA NA Human Human DTXSID0045254 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045254 TK.Half.Life NA 6.194 hours 1compartment NA NA Human Human -DTXSID0045254 Css NA 0.44 mg/L 3compartmentss NA 50% Human Human -DTXSID0045254 Css NA 3.071 mg/L 3compartmentss NA 95% Human Human -DTXSID0045254 Css NA 0.2941 mg/L PBTK NA 50% Human Human -DTXSID0045254 Css NA 1.988 mg/L PBTK NA 95% Human Human -DTXSID0045254 Clint NA 16.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045254 Fup NA 0.0981 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045254 Vd NA 1.295 L/kg 1compartment NA NA Rat Human +DTXSID0045254 TK.Half.Life NA 5.216 hours 1compartment NA NA Human Human +DTXSID0045254 Css NA 0.3572 mg/L 3compartmentss NA 50% Human Human +DTXSID0045254 Css NA 2.604 mg/L 3compartmentss NA 95% Human Human +DTXSID0045254 Css NA 0.2363 mg/L PBTK NA 50% Human Human +DTXSID0045254 Css NA 1.624 mg/L PBTK NA 95% Human Human +DTXSID0045254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045254 Fup 0.0893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045254 Vd NA 1.244 L/kg 1compartment NA NA Rat Human DTXSID0045254 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045254 TK.Half.Life NA 2.268 hours 1compartment NA NA Rat Human -DTXSID0045254 Css NA 0.2392 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045254 Css NA 1.348 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045254 Css NA 0.1517 mg/L PBTK NA 50% Rat Human -DTXSID0045254 Css NA 0.7963 mg/L PBTK NA 95% Rat Human -DTXSID0045383 Clint NA 38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0045254 TK.Half.Life NA 1.943 hours 1compartment NA NA Rat Human +DTXSID0045254 Css NA 0.04645 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045254 Css NA 0.269 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045254 Css NA 0.03017 mg/L PBTK NA 50% Rat Human +DTXSID0045254 Css NA 0.1676 mg/L PBTK NA 95% Rat Human +DTXSID0045383 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0045383 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0045383 Vd NA 4.022 L/kg 1compartment NA NA Human Human DTXSID0045383 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045383 TK.Half.Life NA 1.846 hours 1compartment NA NA Human Human -DTXSID0045383 Css NA 0.009426 mg/L 3compartmentss NA 50% Human Human -DTXSID0045383 Css NA 0.1381 mg/L 3compartmentss NA 95% Human Human -DTXSID0045383 Css NA 0.01418 mg/L PBTK NA 50% Human Human -DTXSID0045383 Css NA 0.1253 mg/L PBTK NA 95% Human Human -DTXSID0045383 Clint NA 38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0045383 TK.Half.Life NA 4.338 hours 1compartment NA NA Human Human +DTXSID0045383 Css NA 0.05029 mg/L 3compartmentss NA 50% Human Human +DTXSID0045383 Css NA 0.65 mg/L 3compartmentss NA 95% Human Human +DTXSID0045383 Css NA 0.07532 mg/L PBTK NA 50% Human Human +DTXSID0045383 Css NA 0.6011 mg/L PBTK NA 95% Human Human +DTXSID0045383 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0045383 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0045383 Vd NA 4.008 L/kg 1compartment NA NA Rat Human DTXSID0045383 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045383 TK.Half.Life NA 0.9288 hours 1compartment NA NA Rat Human -DTXSID0045383 Css NA 0.004723 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045383 Css NA 0.06228 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045383 Css NA 0.007281 mg/L PBTK NA 50% Rat Human -DTXSID0045383 Css NA 0.0556 mg/L PBTK NA 95% Rat Human -DTXSID0045385 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045385 Fup NA 0.9201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045385 Vd NA 0.6816 L/kg 1compartment NA NA Human Human +DTXSID0045383 TK.Half.Life NA 2.496 hours 1compartment NA NA Rat Human +DTXSID0045383 Css NA 0.005506 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045383 Css NA 0.06446 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045383 Css NA 0.008812 mg/L PBTK NA 50% Rat Human +DTXSID0045383 Css NA 0.05398 mg/L PBTK NA 95% Rat Human +DTXSID0045385 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045385 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045385 Vd NA 0.5657 L/kg 1compartment NA NA Human Human DTXSID0045385 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045385 TK.Half.Life NA 4.794 hours 1compartment NA NA Human Human -DTXSID0045385 Css NA 0.9288 mg/L 3compartmentss NA 50% Human Human -DTXSID0045385 Css NA 5.139 mg/L 3compartmentss NA 95% Human Human -DTXSID0045385 Css NA 0.7554 mg/L PBTK NA 50% Human Human -DTXSID0045385 Css NA 3.381 mg/L PBTK NA 95% Human Human -DTXSID0045385 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045385 Fup NA 0.9201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045385 Vd NA 0.7265 L/kg 1compartment NA NA Rat Human +DTXSID0045385 TK.Half.Life NA 5.424 hours 1compartment NA NA Human Human +DTXSID0045385 Css NA 0.9838 mg/L 3compartmentss NA 50% Human Human +DTXSID0045385 Css NA 6.207 mg/L 3compartmentss NA 95% Human Human +DTXSID0045385 Css NA 0.7694 mg/L PBTK NA 50% Human Human +DTXSID0045385 Css NA 3.952 mg/L PBTK NA 95% Human Human +DTXSID0045385 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045385 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045385 Vd NA 0.6028 L/kg 1compartment NA NA Rat Human DTXSID0045385 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045385 TK.Half.Life NA 1.741 hours 1compartment NA NA Rat Human -DTXSID0045385 Css NA 0.238 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045385 Css NA 1.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045385 Css NA 0.1881 mg/L PBTK NA 50% Rat Human -DTXSID0045385 Css NA 0.7751 mg/L PBTK NA 95% Rat Human -DTXSID0045389 Clint NA 2.677 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045389 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045389 Vd NA 0.1975 L/kg 1compartment NA NA Human Human -DTXSID0045389 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0045389 TK.Half.Life NA 21.58 hours 1compartment NA NA Human Human -DTXSID0045389 Css NA 19.98 mg/L 3compartmentss NA 50% Human Human -DTXSID0045389 Css NA 156.3 mg/L 3compartmentss NA 95% Human Human -DTXSID0045389 Css NA 11.73 mg/L PBTK NA 50% Human Human -DTXSID0045389 Css NA 89.28 mg/L PBTK NA 95% Human Human -DTXSID0045389 Clint NA 2.677 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045389 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045389 Vd NA 0.1915 L/kg 1compartment NA NA Rat Human -DTXSID0045389 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0045389 TK.Half.Life NA 12.27 hours 1compartment NA NA Rat Human -DTXSID0045389 Css NA 9.728 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045389 Css NA 60.42 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045389 Css NA 5.332 mg/L PBTK NA 50% Rat Human -DTXSID0045389 Css NA 32.69 mg/L PBTK NA 95% Rat Human -DTXSID0045412 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045412 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045412 Vd NA 0.6399 L/kg 1compartment NA NA Human Human +DTXSID0045385 TK.Half.Life NA 1.969 hours 1compartment NA NA Rat Human +DTXSID0045385 Css NA 0.01858 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045385 Css NA 0.1641 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045385 Css NA 0.01388 mg/L PBTK NA 50% Rat Human +DTXSID0045385 Css NA 0.1016 mg/L PBTK NA 95% Rat Human +DTXSID0045389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045389 Fup 0.0419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045389 Vd NA 0.2806 L/kg 1compartment NA NA Human Human +DTXSID0045389 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0045389 TK.Half.Life NA 1.413 hours 1compartment NA NA Human Human +DTXSID0045389 Css NA 0.7386 mg/L 3compartmentss NA 50% Human Human +DTXSID0045389 Css NA 6.145 mg/L 3compartmentss NA 95% Human Human +DTXSID0045389 Css NA 0.4512 mg/L PBTK NA 50% Human Human +DTXSID0045389 Css NA 3.608 mg/L PBTK NA 95% Human Human +DTXSID0045389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045389 Fup 0.0419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045389 Vd NA 0.2702 L/kg 1compartment NA NA Rat Human +DTXSID0045389 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0045389 TK.Half.Life NA 0.8647 hours 1compartment NA NA Rat Human +DTXSID0045389 Css NA 0.09715 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045389 Css NA 0.5661 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045389 Css NA 0.05726 mg/L PBTK NA 50% Rat Human +DTXSID0045389 Css NA 0.3259 mg/L PBTK NA 95% Rat Human +DTXSID0045410 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045410 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045410 Vd NA 1.613 L/kg 1compartment NA NA Human Human +DTXSID0045410 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0045410 TK.Half.Life NA 4.104 hours 1compartment NA NA Human Human +DTXSID0045410 Css NA 0.2539 mg/L 3compartmentss NA 50% Human Human +DTXSID0045410 Css NA 1.845 mg/L 3compartmentss NA 95% Human Human +DTXSID0045410 Css NA 0.1717 mg/L PBTK NA 50% Human Human +DTXSID0045410 Css NA 1.202 mg/L PBTK NA 95% Human Human +DTXSID0045410 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045410 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045410 Vd NA 1.239 L/kg 1compartment NA NA Rat Human +DTXSID0045410 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0045410 TK.Half.Life NA 1.547 hours 1compartment NA NA Rat Human +DTXSID0045410 Css NA 0.03281 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045410 Css NA 0.1913 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045410 Css NA 0.0218 mg/L PBTK NA 50% Rat Human +DTXSID0045410 Css NA 0.1191 mg/L PBTK NA 95% Rat Human +DTXSID0045412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045412 Fup 0.642 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045412 Vd NA 0.3925 L/kg 1compartment NA NA Human Human DTXSID0045412 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045412 TK.Half.Life NA 4.141 hours 1compartment NA NA Human Human -DTXSID0045412 Css NA 0.8838 mg/L 3compartmentss NA 50% Human Human -DTXSID0045412 Css NA 5.667 mg/L 3compartmentss NA 95% Human Human -DTXSID0045412 Css NA 0.6987 mg/L PBTK NA 50% Human Human -DTXSID0045412 Css NA 3.648 mg/L PBTK NA 95% Human Human -DTXSID0045412 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045412 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045412 Vd NA 0.6675 L/kg 1compartment NA NA Rat Human +DTXSID0045412 TK.Half.Life NA 3.956 hours 1compartment NA NA Human Human +DTXSID0045412 Css NA 0.7078 mg/L 3compartmentss NA 50% Human Human +DTXSID0045412 Css NA 4.535 mg/L 3compartmentss NA 95% Human Human +DTXSID0045412 Css NA 0.5078 mg/L PBTK NA 50% Human Human +DTXSID0045412 Css NA 2.798 mg/L PBTK NA 95% Human Human +DTXSID0045412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045412 Fup 0.642 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045412 Vd NA 0.4114 L/kg 1compartment NA NA Rat Human DTXSID0045412 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045412 TK.Half.Life NA 1.472 hours 1compartment NA NA Rat Human -DTXSID0045412 Css NA 0.2233 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045412 Css NA 1.357 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045412 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID0045412 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0045414 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045414 Fup NA 0.8119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045414 Vd NA 3.141 L/kg 1compartment NA NA Human Human -DTXSID0045414 Days.Css NA 631 Days PBTK NA NA Human Human -DTXSID0045414 TK.Half.Life NA 2377 hours 1compartment NA NA Human Human -DTXSID0045414 Css NA 84 mg/L 3compartmentss NA 50% Human Human -DTXSID0045414 Css NA 239.2 mg/L 3compartmentss NA 95% Human Human -DTXSID0045414 Css NA 59.97 mg/L PBTK NA 50% Human Human -DTXSID0045414 Css NA 156.3 mg/L PBTK NA 95% Human Human -DTXSID0045414 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045414 Fup NA 0.8119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045414 Vd NA 2.364 L/kg 1compartment NA NA Rat Human -DTXSID0045414 Days.Css NA 159 Days PBTK NA NA Rat Human -DTXSID0045414 TK.Half.Life NA 150.2 hours 1compartment NA NA Rat Human -DTXSID0045414 Css NA 22.97 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045414 Css NA 51.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045414 Css NA 15.65 mg/L PBTK NA 50% Rat Human -DTXSID0045414 Css NA 31.27 mg/L PBTK NA 95% Rat Human -DTXSID0045416 Clint NA 10.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045416 Fup NA 0.4535 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045416 Vd NA 2.416 L/kg 1compartment NA NA Human Human +DTXSID0045412 TK.Half.Life NA 1.413 hours 1compartment NA NA Rat Human +DTXSID0045412 Css NA 0.003796 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045412 Css NA 0.02442 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045412 Css NA 0.002589 mg/L PBTK NA 50% Rat Human +DTXSID0045412 Css NA 0.01428 mg/L PBTK NA 95% Rat Human +DTXSID0045414 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045414 Fup 0.0746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045414 Vd NA 3.155 L/kg 1compartment NA NA Human Human +DTXSID0045414 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID0045414 TK.Half.Life NA 119.1 hours 1compartment NA NA Human Human +DTXSID0045414 Css NA 3.93 mg/L 3compartmentss NA 50% Human Human +DTXSID0045414 Css NA 25.56 mg/L 3compartmentss NA 95% Human Human +DTXSID0045414 Css NA 2.752 mg/L PBTK NA 50% Human Human +DTXSID0045414 Css NA 17.23 mg/L PBTK NA 95% Human Human +DTXSID0045414 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045414 Fup 0.0746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045414 Vd NA 2.379 L/kg 1compartment NA NA Rat Human +DTXSID0045414 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID0045414 TK.Half.Life NA 16.06 hours 1compartment NA NA Rat Human +DTXSID0045414 Css NA 0.1955 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045414 Css NA 1.291 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045414 Css NA 0.1334 mg/L PBTK NA 50% Rat Human +DTXSID0045414 Css NA 0.8476 mg/L PBTK NA 95% Rat Human +DTXSID0045416 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045416 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045416 Vd NA 1.962 L/kg 1compartment NA NA Human Human DTXSID0045416 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045416 TK.Half.Life NA 4.548 hours 1compartment NA NA Human Human -DTXSID0045416 Css NA 0.14 mg/L 3compartmentss NA 50% Human Human -DTXSID0045416 Css NA 0.9346 mg/L 3compartmentss NA 95% Human Human -DTXSID0045416 Css NA 0.1174 mg/L PBTK NA 50% Human Human -DTXSID0045416 Css NA 0.7018 mg/L PBTK NA 95% Human Human -DTXSID0045416 Clint NA 10.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045416 Fup NA 0.4535 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045416 Vd NA 1.983 L/kg 1compartment NA NA Rat Human +DTXSID0045416 TK.Half.Life NA 6.665 hours 1compartment NA NA Human Human +DTXSID0045416 Css NA 0.3098 mg/L 3compartmentss NA 50% Human Human +DTXSID0045416 Css NA 1.78 mg/L 3compartmentss NA 95% Human Human +DTXSID0045416 Css NA 0.2385 mg/L PBTK NA 50% Human Human +DTXSID0045416 Css NA 1.257 mg/L PBTK NA 95% Human Human +DTXSID0045416 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045416 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045416 Vd NA 1.601 L/kg 1compartment NA NA Rat Human DTXSID0045416 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045416 TK.Half.Life NA 1.574 hours 1compartment NA NA Rat Human -DTXSID0045416 Css NA 0.07326 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045416 Css NA 0.357 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045416 Css NA 0.05971 mg/L PBTK NA 50% Rat Human -DTXSID0045416 Css NA 0.2521 mg/L PBTK NA 95% Rat Human -DTXSID0045460 Clint NA 7.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045460 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045460 Vd NA 2.637 L/kg 1compartment NA NA Human Human -DTXSID0045460 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID0045460 TK.Half.Life NA 74.06 hours 1compartment NA NA Human Human -DTXSID0045460 Css NA 3.993 mg/L 3compartmentss NA 50% Human Human -DTXSID0045460 Css NA 26.22 mg/L 3compartmentss NA 95% Human Human -DTXSID0045460 Css NA 2.692 mg/L PBTK NA 50% Human Human -DTXSID0045460 Css NA 16.85 mg/L PBTK NA 95% Human Human -DTXSID0045460 Clint NA 7.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045460 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045460 Vd NA 1.984 L/kg 1compartment NA NA Rat Human -DTXSID0045460 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID0045460 TK.Half.Life NA 16.61 hours 1compartment NA NA Rat Human -DTXSID0045460 Css NA 2.189 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045460 Css NA 10.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045460 Css NA 1.402 mg/L PBTK NA 50% Rat Human -DTXSID0045460 Css NA 6.353 mg/L PBTK NA 95% Rat Human -DTXSID0045462 Clint NA 0.3504 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0045416 TK.Half.Life NA 2.531 hours 1compartment NA NA Rat Human +DTXSID0045416 Css NA 0.03666 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045416 Css NA 0.1519 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045416 Css NA 0.02844 mg/L PBTK NA 50% Rat Human +DTXSID0045416 Css NA 0.1054 mg/L PBTK NA 95% Rat Human +DTXSID0045460 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045460 Fup 0.0553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045460 Vd NA 2.808 L/kg 1compartment NA NA Human Human +DTXSID0045460 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0045460 TK.Half.Life NA 24.27 hours 1compartment NA NA Human Human +DTXSID0045460 Css NA 1.04 mg/L 3compartmentss NA 50% Human Human +DTXSID0045460 Css NA 6.862 mg/L 3compartmentss NA 95% Human Human +DTXSID0045460 Css NA 0.7155 mg/L PBTK NA 50% Human Human +DTXSID0045460 Css NA 4.545 mg/L PBTK NA 95% Human Human +DTXSID0045460 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045460 Fup 0.0553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045460 Vd NA 2.121 L/kg 1compartment NA NA Rat Human +DTXSID0045460 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0045460 TK.Half.Life NA 5.115 hours 1compartment NA NA Rat Human +DTXSID0045460 Css NA 0.1343 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045460 Css NA 0.7144 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045460 Css NA 0.0912 mg/L PBTK NA 50% Rat Human +DTXSID0045460 Css NA 0.4804 mg/L PBTK NA 95% Rat Human +DTXSID0045462 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0045462 Fup 0.035 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0045462 Vd NA 0.2439 L/kg 1compartment NA NA Human Human -DTXSID0045462 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID0045462 TK.Half.Life NA 28.55 hours 1compartment NA NA Human Human -DTXSID0045462 Css NA 20.38 mg/L 3compartmentss NA 50% Human Human -DTXSID0045462 Css NA 94.76 mg/L 3compartmentss NA 95% Human Human -DTXSID0045462 Css NA 12.2 mg/L PBTK NA 50% Human Human -DTXSID0045462 Css NA 55.37 mg/L PBTK NA 95% Human Human -DTXSID0045462 Clint NA 0.3504 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0045462 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0045462 TK.Half.Life NA 4.158 hours 1compartment NA NA Human Human +DTXSID0045462 Css NA 3.048 mg/L 3compartmentss NA 50% Human Human +DTXSID0045462 Css NA 19.86 mg/L 3compartmentss NA 95% Human Human +DTXSID0045462 Css NA 1.816 mg/L PBTK NA 50% Human Human +DTXSID0045462 Css NA 11.66 mg/L PBTK NA 95% Human Human +DTXSID0045462 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0045462 Fup 0.035 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0045462 Vd NA 0.2371 L/kg 1compartment NA NA Rat Human -DTXSID0045462 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0045462 TK.Half.Life NA 11.66 hours 1compartment NA NA Rat Human -DTXSID0045462 Css NA 7.216 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045462 Css NA 27.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045462 Css NA 4.04 mg/L PBTK NA 50% Rat Human -DTXSID0045462 Css NA 15.15 mg/L PBTK NA 95% Rat Human -DTXSID0045464 Clint NA 13.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045464 Fup NA 0.007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045464 Vd NA 40.75 L/kg 1compartment NA NA Human Human -DTXSID0045464 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID0045464 TK.Half.Life NA 66.08 hours 1compartment NA NA Human Human -DTXSID0045464 Css NA 0.04278 mg/L 3compartmentss NA 50% Human Human -DTXSID0045464 Css NA 0.7149 mg/L 3compartmentss NA 95% Human Human -DTXSID0045464 Css NA 0.1649 mg/L PBTK NA 50% Human Human -DTXSID0045464 Css NA 1.345 mg/L PBTK NA 95% Human Human -DTXSID0045464 Clint NA 13.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045464 Fup NA 0.007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045464 Vd NA 34.42 L/kg 1compartment NA NA Rat Human -DTXSID0045464 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID0045464 TK.Half.Life NA 26.83 hours 1compartment NA NA Rat Human -DTXSID0045464 Css NA 0.02138 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045464 Css NA 0.3511 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045464 Css NA 0.08788 mg/L PBTK NA 50% Rat Human -DTXSID0045464 Css NA 0.6564 mg/L PBTK NA 95% Rat Human -DTXSID0045466 Clint NA 30.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045466 Fup NA 0.324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045466 Vd NA 1.011 L/kg 1compartment NA NA Human Human +DTXSID0045462 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0045462 TK.Half.Life NA 2.545 hours 1compartment NA NA Rat Human +DTXSID0045462 Css NA 0.3746 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045462 Css NA 1.793 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045462 Css NA 0.2174 mg/L PBTK NA 50% Rat Human +DTXSID0045462 Css NA 1.015 mg/L PBTK NA 95% Rat Human +DTXSID0045464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045464 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045464 Vd NA 11.78 L/kg 1compartment NA NA Human Human +DTXSID0045464 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0045464 TK.Half.Life NA 11.13 hours 1compartment NA NA Human Human +DTXSID0045464 Css NA 0.04109 mg/L 3compartmentss NA 50% Human Human +DTXSID0045464 Css NA 0.4104 mg/L 3compartmentss NA 95% Human Human +DTXSID0045464 Css NA 0.05637 mg/L PBTK NA 50% Human Human +DTXSID0045464 Css NA 0.427 mg/L PBTK NA 95% Human Human +DTXSID0045464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045464 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045464 Vd NA 9.601 L/kg 1compartment NA NA Rat Human +DTXSID0045464 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0045464 TK.Half.Life NA 3.44 hours 1compartment NA NA Rat Human +DTXSID0045464 Css NA 0.005087 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045464 Css NA 0.04299 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045464 Css NA 0.007303 mg/L PBTK NA 50% Rat Human +DTXSID0045464 Css NA 0.04676 mg/L PBTK NA 95% Rat Human +DTXSID0045466 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045466 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045466 Vd NA 0.5353 L/kg 1compartment NA NA Human Human DTXSID0045466 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045466 TK.Half.Life NA 1.081 hours 1compartment NA NA Human Human -DTXSID0045466 Css NA 0.04432 mg/L 3compartmentss NA 50% Human Human -DTXSID0045466 Css NA 0.3366 mg/L 3compartmentss NA 95% Human Human -DTXSID0045466 Css NA 0.03373 mg/L PBTK NA 50% Human Human -DTXSID0045466 Css NA 0.2295 mg/L PBTK NA 95% Human Human -DTXSID0045466 Clint NA 30.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045466 Fup NA 0.324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045466 Vd NA 1.009 L/kg 1compartment NA NA Rat Human +DTXSID0045466 TK.Half.Life NA 0.7077 hours 1compartment NA NA Human Human +DTXSID0045466 Css NA 0.05712 mg/L 3compartmentss NA 50% Human Human +DTXSID0045466 Css NA 0.4393 mg/L 3compartmentss NA 95% Human Human +DTXSID0045466 Css NA 0.04018 mg/L PBTK NA 50% Human Human +DTXSID0045466 Css NA 0.2909 mg/L PBTK NA 95% Human Human +DTXSID0045466 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045466 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045466 Vd NA 0.5225 L/kg 1compartment NA NA Rat Human DTXSID0045466 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045466 TK.Half.Life NA 0.5554 hours 1compartment NA NA Rat Human -DTXSID0045466 Css NA 0.02376 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045466 Css NA 0.1499 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045466 Css NA 0.01762 mg/L PBTK NA 50% Rat Human -DTXSID0045466 Css NA 0.09883 mg/L PBTK NA 95% Rat Human -DTXSID0045468 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045468 Fup NA 0.1378 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045468 Vd NA 0.8031 L/kg 1compartment NA NA Human Human +DTXSID0045466 TK.Half.Life NA 0.3658 hours 1compartment NA NA Rat Human +DTXSID0045466 Css NA 0.002709 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045466 Css NA 0.02369 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045466 Css NA 0.001878 mg/L PBTK NA 50% Rat Human +DTXSID0045466 Css NA 0.01509 mg/L PBTK NA 95% Rat Human +DTXSID0045468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045468 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045468 Vd NA 0.5036 L/kg 1compartment NA NA Human Human DTXSID0045468 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045468 TK.Half.Life NA 1.247 hours 1compartment NA NA Human Human -DTXSID0045468 Css NA 0.114 mg/L 3compartmentss NA 50% Human Human -DTXSID0045468 Css NA 0.9811 mg/L 3compartmentss NA 95% Human Human -DTXSID0045468 Css NA 0.07641 mg/L PBTK NA 50% Human Human -DTXSID0045468 Css NA 0.612 mg/L PBTK NA 95% Human Human -DTXSID0045468 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045468 Fup NA 0.1378 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045468 Vd NA 0.7767 L/kg 1compartment NA NA Rat Human +DTXSID0045468 TK.Half.Life NA 0.9553 hours 1compartment NA NA Human Human +DTXSID0045468 Css NA 0.128 mg/L 3compartmentss NA 50% Human Human +DTXSID0045468 Css NA 1.07 mg/L 3compartmentss NA 95% Human Human +DTXSID0045468 Css NA 0.08341 mg/L PBTK NA 50% Human Human +DTXSID0045468 Css NA 0.6624 mg/L PBTK NA 95% Human Human +DTXSID0045468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045468 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045468 Vd NA 0.4609 L/kg 1compartment NA NA Rat Human DTXSID0045468 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045468 TK.Half.Life NA 0.6646 hours 1compartment NA NA Rat Human -DTXSID0045468 Css NA 0.06432 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045468 Css NA 0.4404 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045468 Css NA 0.04106 mg/L PBTK NA 50% Rat Human -DTXSID0045468 Css NA 0.257 mg/L PBTK NA 95% Rat Human -DTXSID0045543 Clint NA 11.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045543 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045543 Vd NA 8.7 L/kg 1compartment NA NA Human Human +DTXSID0045468 TK.Half.Life NA 0.4926 hours 1compartment NA NA Rat Human +DTXSID0045468 Css NA 0.006325 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045468 Css NA 0.05502 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045468 Css NA 0.004023 mg/L PBTK NA 50% Rat Human +DTXSID0045468 Css NA 0.03297 mg/L PBTK NA 95% Rat Human +DTXSID0045543 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045543 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045543 Vd NA 0.8698 L/kg 1compartment NA NA Human Human DTXSID0045543 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045543 TK.Half.Life NA 4.021 hours 1compartment NA NA Human Human -DTXSID0045543 Css NA 0.01422 mg/L 3compartmentss NA 50% Human Human -DTXSID0045543 Css NA 0.2362 mg/L 3compartmentss NA 95% Human Human -DTXSID0045543 Css NA 0.03202 mg/L PBTK NA 50% Human Human -DTXSID0045543 Css NA 0.3217 mg/L PBTK NA 95% Human Human -DTXSID0045543 Clint NA 11.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045543 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045543 Vd NA 8.964 L/kg 1compartment NA NA Rat Human +DTXSID0045543 TK.Half.Life NA 1.555 hours 1compartment NA NA Human Human +DTXSID0045543 Css NA 0.1314 mg/L 3compartmentss NA 50% Human Human +DTXSID0045543 Css NA 0.9876 mg/L 3compartmentss NA 95% Human Human +DTXSID0045543 Css NA 0.1047 mg/L PBTK NA 50% Human Human +DTXSID0045543 Css NA 0.6865 mg/L PBTK NA 95% Human Human +DTXSID0045543 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045543 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045543 Vd NA 0.8973 L/kg 1compartment NA NA Rat Human DTXSID0045543 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045543 TK.Half.Life NA 2.276 hours 1compartment NA NA Rat Human -DTXSID0045543 Css NA 0.006548 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045543 Css NA 0.09047 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045543 Css NA 0.01584 mg/L PBTK NA 50% Rat Human -DTXSID0045543 Css NA 0.1133 mg/L PBTK NA 95% Rat Human -DTXSID0045545 Clint NA 1.681 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045545 Fup NA 0.0026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045545 Vd NA 1.732 L/kg 1compartment NA NA Human Human -DTXSID0045545 Days.Css NA 197 Days PBTK NA NA Human Human -DTXSID0045545 TK.Half.Life NA 779.1 hours 1compartment NA NA Human Human -DTXSID0045545 Css NA 80.86 mg/L 3compartmentss NA 50% Human Human -DTXSID0045545 Css NA 487.8 mg/L 3compartmentss NA 95% Human Human -DTXSID0045545 Css NA 50.32 mg/L PBTK NA 50% Human Human -DTXSID0045545 Css NA 288.3 mg/L PBTK NA 95% Human Human -DTXSID0045545 Clint NA 1.681 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045545 Fup NA 0.0026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045545 Vd NA 1.276 L/kg 1compartment NA NA Rat Human -DTXSID0045545 Days.Css NA 86 Days PBTK NA NA Rat Human -DTXSID0045545 TK.Half.Life NA 313.9 hours 1compartment NA NA Rat Human -DTXSID0045545 Css NA 40.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045545 Css NA 180.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045545 Css NA 23.8 mg/L PBTK NA 50% Rat Human -DTXSID0045545 Css NA 100.6 mg/L PBTK NA 95% Rat Human -DTXSID0045547 Clint NA 11.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045547 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045547 Vd NA 2.991 L/kg 1compartment NA NA Human Human +DTXSID0045543 TK.Half.Life NA 0.8932 hours 1compartment NA NA Rat Human +DTXSID0045543 Css NA 0.01502 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045543 Css NA 0.08797 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045543 Css NA 0.0121 mg/L PBTK NA 50% Rat Human +DTXSID0045543 Css NA 0.05736 mg/L PBTK NA 95% Rat Human +DTXSID0045547 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045547 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045547 Vd NA 1.562 L/kg 1compartment NA NA Human Human DTXSID0045547 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045547 TK.Half.Life NA 4.316 hours 1compartment NA NA Human Human -DTXSID0045547 Css NA 0.08966 mg/L 3compartmentss NA 50% Human Human -DTXSID0045547 Css NA 0.8528 mg/L 3compartmentss NA 95% Human Human -DTXSID0045547 Css NA 0.08178 mg/L PBTK NA 50% Human Human -DTXSID0045547 Css NA 0.6614 mg/L PBTK NA 95% Human Human -DTXSID0045547 Clint NA 11.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045547 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045547 Vd NA 2.429 L/kg 1compartment NA NA Rat Human +DTXSID0045547 TK.Half.Life NA 2.993 hours 1compartment NA NA Human Human +DTXSID0045547 Css NA 0.1386 mg/L 3compartmentss NA 50% Human Human +DTXSID0045547 Css NA 0.923 mg/L 3compartmentss NA 95% Human Human +DTXSID0045547 Css NA 0.0992 mg/L PBTK NA 50% Human Human +DTXSID0045547 Css NA 0.6231 mg/L PBTK NA 95% Human Human +DTXSID0045547 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045547 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045547 Vd NA 1.252 L/kg 1compartment NA NA Rat Human DTXSID0045547 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045547 TK.Half.Life NA 1.208 hours 1compartment NA NA Rat Human -DTXSID0045547 Css NA 0.04464 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045547 Css NA 0.3206 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045547 Css NA 0.04051 mg/L PBTK NA 50% Rat Human -DTXSID0045547 Css NA 0.2489 mg/L PBTK NA 95% Rat Human -DTXSID0045591 Clint NA 55.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045591 Fup NA 0.4388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045591 Vd NA 1.266 L/kg 1compartment NA NA Human Human +DTXSID0045547 TK.Half.Life NA 1.203 hours 1compartment NA NA Rat Human +DTXSID0045547 Css NA 0.01765 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045547 Css NA 0.09178 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045547 Css NA 0.01256 mg/L PBTK NA 50% Rat Human +DTXSID0045547 Css NA 0.06171 mg/L PBTK NA 95% Rat Human +DTXSID0045591 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045591 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045591 Vd NA 0.4409 L/kg 1compartment NA NA Human Human DTXSID0045591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045591 TK.Half.Life NA 0.9921 hours 1compartment NA NA Human Human -DTXSID0045591 Css NA 0.01716 mg/L 3compartmentss NA 50% Human Human -DTXSID0045591 Css NA 0.149 mg/L 3compartmentss NA 95% Human Human -DTXSID0045591 Css NA 0.01424 mg/L PBTK NA 50% Human Human -DTXSID0045591 Css NA 0.1049 mg/L PBTK NA 95% Human Human -DTXSID0045591 Clint NA 55.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045591 Fup NA 0.4388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045591 Vd NA 1.256 L/kg 1compartment NA NA Rat Human +DTXSID0045591 TK.Half.Life NA 0.6545 hours 1compartment NA NA Human Human +DTXSID0045591 Css NA 0.0563 mg/L 3compartmentss NA 50% Human Human +DTXSID0045591 Css NA 0.5864 mg/L 3compartmentss NA 95% Human Human +DTXSID0045591 Css NA 0.04042 mg/L PBTK NA 50% Human Human +DTXSID0045591 Css NA 0.3726 mg/L PBTK NA 95% Human Human +DTXSID0045591 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045591 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045591 Vd NA 0.4653 L/kg 1compartment NA NA Rat Human DTXSID0045591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045591 TK.Half.Life NA 0.4699 hours 1compartment NA NA Rat Human -DTXSID0045591 Css NA 0.009148 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045591 Css NA 0.0658 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045591 Css NA 0.007418 mg/L PBTK NA 50% Rat Human -DTXSID0045591 Css NA 0.04536 mg/L PBTK NA 95% Rat Human -DTXSID0045595 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045595 Fup NA 0.2385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045595 Vd NA 0.3169 L/kg 1compartment NA NA Human Human -DTXSID0045595 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045595 TK.Half.Life NA 8.598 hours 1compartment NA NA Human Human -DTXSID0045595 Css NA 3.403 mg/L 3compartmentss NA 50% Human Human -DTXSID0045595 Css NA 12.26 mg/L 3compartmentss NA 95% Human Human -DTXSID0045595 Css NA 2.223 mg/L PBTK NA 50% Human Human -DTXSID0045595 Css NA 7.535 mg/L PBTK NA 95% Human Human -DTXSID0045595 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045595 Fup NA 0.2385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045595 Vd NA 0.3269 L/kg 1compartment NA NA Rat Human +DTXSID0045591 TK.Half.Life NA 0.3666 hours 1compartment NA NA Rat Human +DTXSID0045591 Css NA 0.0004966 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045591 Css NA 0.005385 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045591 Css NA 0.0003462 mg/L PBTK NA 50% Rat Human +DTXSID0045591 Css NA 0.003145 mg/L PBTK NA 95% Rat Human +DTXSID0045595 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045595 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045595 Vd NA 0.2806 L/kg 1compartment NA NA Human Human +DTXSID0045595 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0045595 TK.Half.Life NA 10.37 hours 1compartment NA NA Human Human +DTXSID0045595 Css NA 2.593 mg/L 3compartmentss NA 50% Human Human +DTXSID0045595 Css NA 10.79 mg/L 3compartmentss NA 95% Human Human +DTXSID0045595 Css NA 1.644 mg/L PBTK NA 50% Human Human +DTXSID0045595 Css NA 6.399 mg/L PBTK NA 95% Human Human +DTXSID0045595 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045595 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045595 Vd NA 0.2881 L/kg 1compartment NA NA Rat Human DTXSID0045595 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045595 TK.Half.Life NA 3.022 hours 1compartment NA NA Rat Human -DTXSID0045595 Css NA 0.9415 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045595 Css NA 2.844 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045595 Css NA 0.5816 mg/L PBTK NA 50% Rat Human -DTXSID0045595 Css NA 1.615 mg/L PBTK NA 95% Rat Human -DTXSID0045597 Clint NA 0.06691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045597 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045597 Vd NA 0.9532 L/kg 1compartment NA NA Human Human -DTXSID0045597 Days.Css NA 39 Days PBTK NA NA Human Human -DTXSID0045597 TK.Half.Life NA 176.9 hours 1compartment NA NA Human Human -DTXSID0045597 Css NA 29.4 mg/L 3compartmentss NA 50% Human Human -DTXSID0045597 Css NA 124.8 mg/L 3compartmentss NA 95% Human Human -DTXSID0045597 Css NA 18.13 mg/L PBTK NA 50% Human Human -DTXSID0045597 Css NA 73.26 mg/L PBTK NA 95% Human Human -DTXSID0045597 Clint NA 0.06691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045597 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045597 Vd NA 0.7198 L/kg 1compartment NA NA Rat Human -DTXSID0045597 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID0045597 TK.Half.Life NA 43.54 hours 1compartment NA NA Rat Human -DTXSID0045597 Css NA 9.032 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045597 Css NA 32.95 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045597 Css NA 5.201 mg/L PBTK NA 50% Rat Human -DTXSID0045597 Css NA 18.14 mg/L PBTK NA 95% Rat Human -DTXSID0045599 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045599 Fup NA 0.4239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045599 Vd NA 0.7485 L/kg 1compartment NA NA Human Human -DTXSID0045599 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0045599 TK.Half.Life NA 11.74 hours 1compartment NA NA Human Human -DTXSID0045599 Css NA 1.723 mg/L 3compartmentss NA 50% Human Human -DTXSID0045599 Css NA 8.059 mg/L 3compartmentss NA 95% Human Human -DTXSID0045599 Css NA 1.305 mg/L PBTK NA 50% Human Human -DTXSID0045599 Css NA 5.183 mg/L PBTK NA 95% Human Human -DTXSID0045599 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045599 Fup NA 0.4239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045599 Vd NA 0.6931 L/kg 1compartment NA NA Rat Human +DTXSID0045595 TK.Half.Life NA 3.629 hours 1compartment NA NA Rat Human +DTXSID0045595 Css NA 0.01416 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045595 Css NA 0.05797 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045595 Css NA 0.008463 mg/L PBTK NA 50% Rat Human +DTXSID0045595 Css NA 0.03299 mg/L PBTK NA 95% Rat Human +DTXSID0045597 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045597 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045597 Vd NA 0.3578 L/kg 1compartment NA NA Human Human +DTXSID0045597 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0045597 TK.Half.Life NA 0.5436 hours 1compartment NA NA Human Human +DTXSID0045597 Css NA 0.08946 mg/L 3compartmentss NA 50% Human Human +DTXSID0045597 Css NA 0.6569 mg/L 3compartmentss NA 95% Human Human +DTXSID0045597 Css NA 0.05921 mg/L PBTK NA 50% Human Human +DTXSID0045597 Css NA 0.4129 mg/L PBTK NA 95% Human Human +DTXSID0045597 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045597 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045597 Vd NA 0.3666 L/kg 1compartment NA NA Rat Human +DTXSID0045597 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0045597 TK.Half.Life NA 0.3011 hours 1compartment NA NA Rat Human +DTXSID0045597 Css NA 0.01162 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045597 Css NA 0.06185 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045597 Css NA 0.007522 mg/L PBTK NA 50% Rat Human +DTXSID0045597 Css NA 0.0388 mg/L PBTK NA 95% Rat Human +DTXSID0045599 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045599 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045599 Vd NA 0.379 L/kg 1compartment NA NA Human Human +DTXSID0045599 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0045599 TK.Half.Life NA 6.558 hours 1compartment NA NA Human Human +DTXSID0045599 Css NA 1.114 mg/L 3compartmentss NA 50% Human Human +DTXSID0045599 Css NA 5.047 mg/L 3compartmentss NA 95% Human Human +DTXSID0045599 Css NA 0.7668 mg/L PBTK NA 50% Human Human +DTXSID0045599 Css NA 3.128 mg/L PBTK NA 95% Human Human +DTXSID0045599 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045599 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045599 Vd NA 0.3974 L/kg 1compartment NA NA Rat Human DTXSID0045599 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045599 TK.Half.Life NA 3.629 hours 1compartment NA NA Rat Human -DTXSID0045599 Css NA 0.4683 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045599 Css NA 1.798 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045599 Css NA 0.339 mg/L PBTK NA 50% Rat Human -DTXSID0045599 Css NA 1.075 mg/L PBTK NA 95% Rat Human -DTXSID0045624 Clint NA 0.1988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045624 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045624 Vd NA 1.388 L/kg 1compartment NA NA Human Human -DTXSID0045624 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0045624 TK.Half.Life NA 14.14 hours 1compartment NA NA Human Human -DTXSID0045624 Css NA 1.002 mg/L 3compartmentss NA 50% Human Human -DTXSID0045624 Css NA 5.623 mg/L 3compartmentss NA 95% Human Human -DTXSID0045624 Css NA 0.8592 mg/L PBTK NA 50% Human Human -DTXSID0045624 Css NA 3.675 mg/L PBTK NA 95% Human Human -DTXSID0045624 Clint NA 0.1988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045624 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045624 Vd NA 1.254 L/kg 1compartment NA NA Rat Human +DTXSID0045599 TK.Half.Life NA 2.343 hours 1compartment NA NA Rat Human +DTXSID0045599 Css NA 0.006028 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045599 Css NA 0.02682 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045599 Css NA 0.003932 mg/L PBTK NA 50% Rat Human +DTXSID0045599 Css NA 0.01587 mg/L PBTK NA 95% Rat Human +DTXSID0045624 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045624 Fup 0.651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045624 Vd NA 1.56 L/kg 1compartment NA NA Human Human +DTXSID0045624 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0045624 TK.Half.Life NA 17.49 hours 1compartment NA NA Human Human +DTXSID0045624 Css NA 1.073 mg/L 3compartmentss NA 50% Human Human +DTXSID0045624 Css NA 6.975 mg/L 3compartmentss NA 95% Human Human +DTXSID0045624 Css NA 0.9745 mg/L PBTK NA 50% Human Human +DTXSID0045624 Css NA 4.704 mg/L PBTK NA 95% Human Human +DTXSID0045624 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045624 Fup 0.651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045624 Vd NA 1.415 L/kg 1compartment NA NA Rat Human DTXSID0045624 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045624 TK.Half.Life NA 4.63 hours 1compartment NA NA Rat Human -DTXSID0045624 Css NA 0.3126 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045624 Css NA 1.655 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045624 Css NA 0.2586 mg/L PBTK NA 50% Rat Human -DTXSID0045624 Css NA 1.013 mg/L PBTK NA 95% Rat Human -DTXSID0045626 Clint NA 0.6077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0045624 TK.Half.Life NA 4.937 hours 1compartment NA NA Rat Human +DTXSID0045624 Css NA 0.06502 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045624 Css NA 0.4108 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045624 Css NA 0.05948 mg/L PBTK NA 50% Rat Human +DTXSID0045624 Css NA 0.2626 mg/L PBTK NA 95% Rat Human +DTXSID0045626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0045626 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0045626 Vd NA 0.3036 L/kg 1compartment NA NA Human Human DTXSID0045626 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045626 TK.Half.Life NA 5.8 hours 1compartment NA NA Human Human -DTXSID0045626 Css NA 2.41 mg/L 3compartmentss NA 50% Human Human -DTXSID0045626 Css NA 9.761 mg/L 3compartmentss NA 95% Human Human -DTXSID0045626 Css NA 1.55 mg/L PBTK NA 50% Human Human -DTXSID0045626 Css NA 5.882 mg/L PBTK NA 95% Human Human -DTXSID0045626 Clint NA 0.6077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0045626 TK.Half.Life NA 0.5613 hours 1compartment NA NA Human Human +DTXSID0045626 Css NA 0.1353 mg/L 3compartmentss NA 50% Human Human +DTXSID0045626 Css NA 0.9396 mg/L 3compartmentss NA 95% Human Human +DTXSID0045626 Css NA 0.08632 mg/L PBTK NA 50% Human Human +DTXSID0045626 Css NA 0.5937 mg/L PBTK NA 95% Human Human +DTXSID0045626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0045626 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0045626 Vd NA 0.3042 L/kg 1compartment NA NA Rat Human DTXSID0045626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045626 TK.Half.Life NA 2.656 hours 1compartment NA NA Rat Human -DTXSID0045626 Css NA 0.9272 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045626 Css NA 3.014 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045626 Css NA 0.5596 mg/L PBTK NA 50% Rat Human -DTXSID0045626 Css NA 1.69 mg/L PBTK NA 95% Rat Human -DTXSID0045670 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045670 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045670 Vd NA 0.7129 L/kg 1compartment NA NA Human Human +DTXSID0045626 TK.Half.Life NA 0.3159 hours 1compartment NA NA Rat Human +DTXSID0045626 Css NA 0.01755 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045626 Css NA 0.09304 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045626 Css NA 0.01099 mg/L PBTK NA 50% Rat Human +DTXSID0045626 Css NA 0.05596 mg/L PBTK NA 95% Rat Human +DTXSID0045670 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045670 Fup 0.916 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045670 Vd NA 1.004 L/kg 1compartment NA NA Human Human DTXSID0045670 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045670 TK.Half.Life NA 4.615 hours 1compartment NA NA Human Human -DTXSID0045670 Css NA 0.8446 mg/L 3compartmentss NA 50% Human Human -DTXSID0045670 Css NA 5.538 mg/L 3compartmentss NA 95% Human Human -DTXSID0045670 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID0045670 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID0045670 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045670 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045670 Vd NA 0.7595 L/kg 1compartment NA NA Rat Human +DTXSID0045670 TK.Half.Life NA 7.166 hours 1compartment NA NA Human Human +DTXSID0045670 Css NA 0.8074 mg/L 3compartmentss NA 50% Human Human +DTXSID0045670 Css NA 3.163 mg/L 3compartmentss NA 95% Human Human +DTXSID0045670 Css NA 0.7071 mg/L PBTK NA 50% Human Human +DTXSID0045670 Css NA 2.242 mg/L PBTK NA 95% Human Human +DTXSID0045670 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045670 Fup 0.916 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045670 Vd NA 1.006 L/kg 1compartment NA NA Rat Human DTXSID0045670 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045670 TK.Half.Life NA 1.674 hours 1compartment NA NA Rat Human -DTXSID0045670 Css NA 0.2123 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045670 Css NA 1.315 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045670 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID0045670 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID0045674 Clint NA 15.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045674 Fup NA 0.255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045674 Vd NA 3.524 L/kg 1compartment NA NA Human Human +DTXSID0045670 TK.Half.Life NA 2.428 hours 1compartment NA NA Rat Human +DTXSID0045670 Css NA 0.04814 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045670 Css NA 0.179 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045670 Css NA 0.043 mg/L PBTK NA 50% Rat Human +DTXSID0045670 Css NA 0.1213 mg/L PBTK NA 95% Rat Human +DTXSID0045674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045674 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045674 Vd NA 2.398 L/kg 1compartment NA NA Human Human DTXSID0045674 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045674 TK.Half.Life NA 7.411 hours 1compartment NA NA Human Human -DTXSID0045674 Css NA 0.147 mg/L 3compartmentss NA 50% Human Human -DTXSID0045674 Css NA 0.9925 mg/L 3compartmentss NA 95% Human Human -DTXSID0045674 Css NA 0.1358 mg/L PBTK NA 50% Human Human -DTXSID0045674 Css NA 0.8142 mg/L PBTK NA 95% Human Human -DTXSID0045674 Clint NA 15.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045674 Fup NA 0.255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045674 Vd NA 3.099 L/kg 1compartment NA NA Rat Human +DTXSID0045674 TK.Half.Life NA 6.359 hours 1compartment NA NA Human Human +DTXSID0045674 Css NA 0.2255 mg/L 3compartmentss NA 50% Human Human +DTXSID0045674 Css NA 1.509 mg/L 3compartmentss NA 95% Human Human +DTXSID0045674 Css NA 0.1614 mg/L PBTK NA 50% Human Human +DTXSID0045674 Css NA 1.028 mg/L PBTK NA 95% Human Human +DTXSID0045674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045674 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045674 Vd NA 1.822 L/kg 1compartment NA NA Rat Human DTXSID0045674 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045674 TK.Half.Life NA 2.567 hours 1compartment NA NA Rat Human -DTXSID0045674 Css NA 0.07854 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045674 Css NA 0.4047 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045674 Css NA 0.0714 mg/L PBTK NA 50% Rat Human -DTXSID0045674 Css NA 0.3288 mg/L PBTK NA 95% Rat Human -DTXSID0045676 Clint NA 13.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045676 Fup NA 0.048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045676 Vd NA 0.8021 L/kg 1compartment NA NA Human Human +DTXSID0045674 TK.Half.Life NA 1.825 hours 1compartment NA NA Rat Human +DTXSID0045674 Css NA 0.02855 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045674 Css NA 0.1408 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045674 Css NA 0.02042 mg/L PBTK NA 50% Rat Human +DTXSID0045674 Css NA 0.09732 mg/L PBTK NA 95% Rat Human +DTXSID0045676 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045676 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045676 Vd NA 1.312 L/kg 1compartment NA NA Human Human DTXSID0045676 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045676 TK.Half.Life NA 5.352 hours 1compartment NA NA Human Human -DTXSID0045676 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human -DTXSID0045676 Css NA 8.063 mg/L 3compartmentss NA 95% Human Human -DTXSID0045676 Css NA 0.6426 mg/L PBTK NA 50% Human Human -DTXSID0045676 Css NA 4.839 mg/L PBTK NA 95% Human Human -DTXSID0045676 Clint NA 13.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045676 Fup NA 0.048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045676 Vd NA 0.6211 L/kg 1compartment NA NA Rat Human +DTXSID0045676 TK.Half.Life NA 7.442 hours 1compartment NA NA Human Human +DTXSID0045676 Css NA 0.7177 mg/L 3compartmentss NA 50% Human Human +DTXSID0045676 Css NA 4.781 mg/L 3compartmentss NA 95% Human Human +DTXSID0045676 Css NA 0.4823 mg/L PBTK NA 50% Human Human +DTXSID0045676 Css NA 2.999 mg/L PBTK NA 95% Human Human +DTXSID0045676 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045676 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045676 Vd NA 1.023 L/kg 1compartment NA NA Rat Human DTXSID0045676 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045676 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human -DTXSID0045676 Css NA 0.5841 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045676 Css NA 3.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045676 Css NA 0.3379 mg/L PBTK NA 50% Rat Human -DTXSID0045676 Css NA 1.936 mg/L PBTK NA 95% Rat Human -DTXSID0045678 Clint NA 413.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045678 Fup NA 0.2349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045678 Vd NA 0.9213 L/kg 1compartment NA NA Human Human +DTXSID0045676 TK.Half.Life NA 3.044 hours 1compartment NA NA Rat Human +DTXSID0045676 Css NA 0.08734 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045676 Css NA 0.4309 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045676 Css NA 0.0574 mg/L PBTK NA 50% Rat Human +DTXSID0045676 Css NA 0.2598 mg/L PBTK NA 95% Rat Human +DTXSID0045678 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045678 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045678 Vd NA 0.8276 L/kg 1compartment NA NA Human Human DTXSID0045678 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045678 TK.Half.Life NA 0.7472 hours 1compartment NA NA Human Human -DTXSID0045678 Css NA 0.004969 mg/L 3compartmentss NA 50% Human Human -DTXSID0045678 Css NA 0.03789 mg/L 3compartmentss NA 95% Human Human -DTXSID0045678 Css NA 0.00355 mg/L PBTK NA 50% Human Human -DTXSID0045678 Css NA 0.02552 mg/L PBTK NA 95% Human Human -DTXSID0045678 Clint NA 413.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045678 Fup NA 0.2349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045678 Vd NA 0.8429 L/kg 1compartment NA NA Rat Human +DTXSID0045678 TK.Half.Life NA 4.404 hours 1compartment NA NA Human Human +DTXSID0045678 Css NA 0.6055 mg/L 3compartmentss NA 50% Human Human +DTXSID0045678 Css NA 4.399 mg/L 3compartmentss NA 95% Human Human +DTXSID0045678 Css NA 0.3952 mg/L PBTK NA 50% Human Human +DTXSID0045678 Css NA 2.654 mg/L PBTK NA 95% Human Human +DTXSID0045678 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045678 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045678 Vd NA 0.6613 L/kg 1compartment NA NA Rat Human DTXSID0045678 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045678 TK.Half.Life NA 0.3049 hours 1compartment NA NA Rat Human -DTXSID0045678 Css NA 0.002761 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045678 Css NA 0.01747 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045678 Css NA 0.001899 mg/L PBTK NA 50% Rat Human -DTXSID0045678 Css NA 0.01115 mg/L PBTK NA 95% Rat Human -DTXSID0045701 Clint NA 25.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045701 Fup NA 0.3685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045701 Vd NA 0.3709 L/kg 1compartment NA NA Human Human +DTXSID0045678 TK.Half.Life NA 2.011 hours 1compartment NA NA Rat Human +DTXSID0045678 Css NA 0.02777 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045678 Css NA 0.2185 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045678 Css NA 0.0176 mg/L PBTK NA 50% Rat Human +DTXSID0045678 Css NA 0.1302 mg/L PBTK NA 95% Rat Human +DTXSID0045701 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045701 Fup 0.413 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045701 Vd NA 0.3195 L/kg 1compartment NA NA Human Human DTXSID0045701 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045701 TK.Half.Life NA 0.4348 hours 1compartment NA NA Human Human -DTXSID0045701 Css NA 0.05295 mg/L 3compartmentss NA 50% Human Human -DTXSID0045701 Css NA 0.4016 mg/L 3compartmentss NA 95% Human Human -DTXSID0045701 Css NA 0.03599 mg/L PBTK NA 50% Human Human -DTXSID0045701 Css NA 0.2571 mg/L PBTK NA 95% Human Human -DTXSID0045701 Clint NA 25.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045701 Fup NA 0.3685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045701 Vd NA 0.376 L/kg 1compartment NA NA Rat Human +DTXSID0045701 TK.Half.Life NA 0.6353 hours 1compartment NA NA Human Human +DTXSID0045701 Css NA 0.1649 mg/L 3compartmentss NA 50% Human Human +DTXSID0045701 Css NA 1.048 mg/L 3compartmentss NA 95% Human Human +DTXSID0045701 Css NA 0.1098 mg/L PBTK NA 50% Human Human +DTXSID0045701 Css NA 0.6632 mg/L PBTK NA 95% Human Human +DTXSID0045701 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045701 Fup 0.413 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045701 Vd NA 0.3358 L/kg 1compartment NA NA Rat Human DTXSID0045701 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045701 TK.Half.Life NA 0.2239 hours 1compartment NA NA Rat Human -DTXSID0045701 Css NA 0.02854 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045701 Css NA 0.1673 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045701 Css NA 0.01843 mg/L PBTK NA 50% Rat Human -DTXSID0045701 Css NA 0.1019 mg/L PBTK NA 95% Rat Human -DTXSID0045703 Clint NA 18.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045703 Fup NA 0.1413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045703 Vd NA 1.071 L/kg 1compartment NA NA Human Human +DTXSID0045701 TK.Half.Life NA 0.3669 hours 1compartment NA NA Rat Human +DTXSID0045701 Css NA 0.01933 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045701 Css NA 0.0962 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045701 Css NA 0.01269 mg/L PBTK NA 50% Rat Human +DTXSID0045701 Css NA 0.05842 mg/L PBTK NA 95% Rat Human +DTXSID0045703 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045703 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045703 Vd NA 0.7187 L/kg 1compartment NA NA Human Human DTXSID0045703 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045703 TK.Half.Life NA 2.438 hours 1compartment NA NA Human Human -DTXSID0045703 Css NA 0.2256 mg/L 3compartmentss NA 50% Human Human -DTXSID0045703 Css NA 1.74 mg/L 3compartmentss NA 95% Human Human -DTXSID0045703 Css NA 0.1513 mg/L PBTK NA 50% Human Human -DTXSID0045703 Css NA 1.089 mg/L PBTK NA 95% Human Human -DTXSID0045703 Clint NA 18.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045703 Fup NA 0.1413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045703 Vd NA 0.8553 L/kg 1compartment NA NA Rat Human +DTXSID0045703 TK.Half.Life NA 2.667 hours 1compartment NA NA Human Human +DTXSID0045703 Css NA 0.3712 mg/L 3compartmentss NA 50% Human Human +DTXSID0045703 Css NA 2.246 mg/L 3compartmentss NA 95% Human Human +DTXSID0045703 Css NA 0.2536 mg/L PBTK NA 50% Human Human +DTXSID0045703 Css NA 1.449 mg/L PBTK NA 95% Human Human +DTXSID0045703 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045703 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045703 Vd NA 0.6239 L/kg 1compartment NA NA Rat Human DTXSID0045703 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045703 TK.Half.Life NA 1.059 hours 1compartment NA NA Rat Human -DTXSID0045703 Css NA 0.1233 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045703 Css NA 0.7401 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045703 Css NA 0.07825 mg/L PBTK NA 50% Rat Human -DTXSID0045703 Css NA 0.4351 mg/L PBTK NA 95% Rat Human -DTXSID0045705 Clint NA 67.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045705 Fup NA 0.525 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045705 Vd NA 2.611 L/kg 1compartment NA NA Human Human +DTXSID0045703 TK.Half.Life NA 1.334 hours 1compartment NA NA Rat Human +DTXSID0045703 Css NA 0.04402 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045703 Css NA 0.1919 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045703 Css NA 0.02973 mg/L PBTK NA 50% Rat Human +DTXSID0045703 Css NA 0.1182 mg/L PBTK NA 95% Rat Human +DTXSID0045705 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045705 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045705 Vd NA 2.296 L/kg 1compartment NA NA Human Human DTXSID0045705 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045705 TK.Half.Life NA 1.448 hours 1compartment NA NA Human Human -DTXSID0045705 Css NA 0.008934 mg/L 3compartmentss NA 50% Human Human -DTXSID0045705 Css NA 0.1016 mg/L 3compartmentss NA 95% Human Human -DTXSID0045705 Css NA 0.009964 mg/L PBTK NA 50% Human Human -DTXSID0045705 Css NA 0.08447 mg/L PBTK NA 95% Human Human -DTXSID0045705 Clint NA 67.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045705 Fup NA 0.525 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045705 Vd NA 2.61 L/kg 1compartment NA NA Rat Human +DTXSID0045705 TK.Half.Life NA 3.725 hours 1compartment NA NA Human Human +DTXSID0045705 Css NA 0.09926 mg/L 3compartmentss NA 50% Human Human +DTXSID0045705 Css NA 0.7947 mg/L 3compartmentss NA 95% Human Human +DTXSID0045705 Css NA 0.1035 mg/L PBTK NA 50% Human Human +DTXSID0045705 Css NA 0.6503 mg/L PBTK NA 95% Human Human +DTXSID0045705 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045705 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045705 Vd NA 2.291 L/kg 1compartment NA NA Rat Human DTXSID0045705 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045705 TK.Half.Life NA 0.6904 hours 1compartment NA NA Rat Human -DTXSID0045705 Css NA 0.00458 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045705 Css NA 0.04607 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045705 Css NA 0.005102 mg/L PBTK NA 50% Rat Human -DTXSID0045705 Css NA 0.03628 mg/L PBTK NA 95% Rat Human -DTXSID0045707 Clint NA 43.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045707 Fup NA 0.1305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045707 Vd NA 1.117 L/kg 1compartment NA NA Human Human +DTXSID0045705 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human +DTXSID0045705 Css NA 0.01118 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045705 Css NA 0.07437 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045705 Css NA 0.0121 mg/L PBTK NA 50% Rat Human +DTXSID0045705 Css NA 0.0565 mg/L PBTK NA 95% Rat Human +DTXSID0045707 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045707 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045707 Vd NA 1.433 L/kg 1compartment NA NA Human Human DTXSID0045707 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045707 TK.Half.Life NA 1.709 hours 1compartment NA NA Human Human -DTXSID0045707 Css NA 0.1112 mg/L 3compartmentss NA 50% Human Human -DTXSID0045707 Css NA 0.9319 mg/L 3compartmentss NA 95% Human Human -DTXSID0045707 Css NA 0.07398 mg/L PBTK NA 50% Human Human -DTXSID0045707 Css NA 0.5869 mg/L PBTK NA 95% Human Human -DTXSID0045707 Clint NA 43.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045707 Fup NA 0.1305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045707 Vd NA 0.8839 L/kg 1compartment NA NA Rat Human +DTXSID0045707 TK.Half.Life NA 2.468 hours 1compartment NA NA Human Human +DTXSID0045707 Css NA 0.1164 mg/L 3compartmentss NA 50% Human Human +DTXSID0045707 Css NA 0.8071 mg/L 3compartmentss NA 95% Human Human +DTXSID0045707 Css NA 0.08346 mg/L PBTK NA 50% Human Human +DTXSID0045707 Css NA 0.5373 mg/L PBTK NA 95% Human Human +DTXSID0045707 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045707 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045707 Vd NA 1.137 L/kg 1compartment NA NA Rat Human DTXSID0045707 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045707 TK.Half.Life NA 0.6954 hours 1compartment NA NA Rat Human -DTXSID0045707 Css NA 0.063 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045707 Css NA 0.3915 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045707 Css NA 0.03956 mg/L PBTK NA 50% Rat Human -DTXSID0045707 Css NA 0.2298 mg/L PBTK NA 95% Rat Human -DTXSID0045709 Clint NA 7.072 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045709 Fup NA 0.3708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045709 Vd NA 0.6342 L/kg 1compartment NA NA Human Human +DTXSID0045707 TK.Half.Life NA 0.9825 hours 1compartment NA NA Rat Human +DTXSID0045707 Css NA 0.01481 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045707 Css NA 0.07568 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045707 Css NA 0.01059 mg/L PBTK NA 50% Rat Human +DTXSID0045707 Css NA 0.0505 mg/L PBTK NA 95% Rat Human +DTXSID0045709 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045709 Fup 0.353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045709 Vd NA 0.599 L/kg 1compartment NA NA Human Human DTXSID0045709 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045709 TK.Half.Life NA 1.275 hours 1compartment NA NA Human Human -DTXSID0045709 Css NA 0.1658 mg/L 3compartmentss NA 50% Human Human -DTXSID0045709 Css NA 1.061 mg/L 3compartmentss NA 95% Human Human -DTXSID0045709 Css NA 0.1205 mg/L PBTK NA 50% Human Human -DTXSID0045709 Css NA 0.7129 mg/L PBTK NA 95% Human Human -DTXSID0045709 Clint NA 7.072 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045709 Fup NA 0.3708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045709 Vd NA 0.6069 L/kg 1compartment NA NA Rat Human +DTXSID0045709 TK.Half.Life NA 1.317 hours 1compartment NA NA Human Human +DTXSID0045709 Css NA 0.176 mg/L 3compartmentss NA 50% Human Human +DTXSID0045709 Css NA 1.166 mg/L 3compartmentss NA 95% Human Human +DTXSID0045709 Css NA 0.1327 mg/L PBTK NA 50% Human Human +DTXSID0045709 Css NA 0.7877 mg/L PBTK NA 95% Human Human +DTXSID0045709 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045709 Fup 0.353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045709 Vd NA 0.6047 L/kg 1compartment NA NA Rat Human DTXSID0045709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045709 TK.Half.Life NA 0.6796 hours 1compartment NA NA Rat Human -DTXSID0045709 Css NA 0.08381 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045709 Css NA 0.4245 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045709 Css NA 0.05864 mg/L PBTK NA 50% Rat Human -DTXSID0045709 Css NA 0.2607 mg/L PBTK NA 95% Rat Human +DTXSID0045709 TK.Half.Life NA 0.7536 hours 1compartment NA NA Rat Human +DTXSID0045709 Css NA 0.0208 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045709 Css NA 0.09902 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045709 Css NA 0.01562 mg/L PBTK NA 50% Rat Human +DTXSID0045709 Css NA 0.06468 mg/L PBTK NA 95% Rat Human DTXSID0045751 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0045751 Fup NA 0.5925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045751 Vd NA 0.6074 L/kg 1compartment NA NA Human Human +DTXSID0045751 Vd NA 0.5434 L/kg 1compartment NA NA Human Human DTXSID0045751 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045751 TK.Half.Life NA 6.633 hours 1compartment NA NA Human Human -DTXSID0045751 Css NA 1.256 mg/L 3compartmentss NA 50% Human Human -DTXSID0045751 Css NA 8.695 mg/L 3compartmentss NA 95% Human Human -DTXSID0045751 Css NA 0.9898 mg/L PBTK NA 50% Human Human -DTXSID0045751 Css NA 5.464 mg/L PBTK NA 95% Human Human +DTXSID0045751 TK.Half.Life NA 5.934 hours 1compartment NA NA Human Human +DTXSID0045751 Css NA 1.096 mg/L 3compartmentss NA 50% Human Human +DTXSID0045751 Css NA 7.63 mg/L 3compartmentss NA 95% Human Human +DTXSID0045751 Css NA 0.8472 mg/L PBTK NA 50% Human Human +DTXSID0045751 Css NA 4.727 mg/L PBTK NA 95% Human Human DTXSID0045751 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0045751 Fup NA 0.5925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045751 Vd NA 0.6309 L/kg 1compartment NA NA Rat Human +DTXSID0045751 Vd NA 0.566 L/kg 1compartment NA NA Rat Human DTXSID0045751 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045751 TK.Half.Life NA 2.347 hours 1compartment NA NA Rat Human -DTXSID0045751 Css NA 0.3314 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045751 Css NA 2.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045751 Css NA 0.2496 mg/L PBTK NA 50% Rat Human -DTXSID0045751 Css NA 1.209 mg/L PBTK NA 95% Rat Human -DTXSID0045753 Clint NA 4.299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045753 Fup NA 0.8183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045753 Vd NA 2.354 L/kg 1compartment NA NA Human Human -DTXSID0045753 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045753 TK.Half.Life NA 3.111 hours 1compartment NA NA Human Human -DTXSID0045753 Css NA 0.1014 mg/L 3compartmentss NA 50% Human Human -DTXSID0045753 Css NA 0.8627 mg/L 3compartmentss NA 95% Human Human -DTXSID0045753 Css NA 0.1067 mg/L PBTK NA 50% Human Human -DTXSID0045753 Css NA 0.6797 mg/L PBTK NA 95% Human Human -DTXSID0045753 Clint NA 4.299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045753 Fup NA 0.8183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045753 Vd NA 2.392 L/kg 1compartment NA NA Rat Human +DTXSID0045751 TK.Half.Life NA 2.106 hours 1compartment NA NA Rat Human +DTXSID0045751 Css NA 0.02086 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045751 Css NA 0.1762 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045751 Css NA 0.0154 mg/L PBTK NA 50% Rat Human +DTXSID0045751 Css NA 0.1088 mg/L PBTK NA 95% Rat Human +DTXSID0045753 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045753 Fup 0.742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045753 Vd NA 2.2 L/kg 1compartment NA NA Human Human +DTXSID0045753 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0045753 TK.Half.Life NA 19.21 hours 1compartment NA NA Human Human +DTXSID0045753 Css NA 0.4466 mg/L 3compartmentss NA 50% Human Human +DTXSID0045753 Css NA 3.474 mg/L 3compartmentss NA 95% Human Human +DTXSID0045753 Css NA 0.4664 mg/L PBTK NA 50% Human Human +DTXSID0045753 Css NA 2.433 mg/L PBTK NA 95% Human Human +DTXSID0045753 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045753 Fup 0.742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045753 Vd NA 2.233 L/kg 1compartment NA NA Rat Human DTXSID0045753 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045753 TK.Half.Life NA 1.729 hours 1compartment NA NA Rat Human -DTXSID0045753 Css NA 0.04526 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045753 Css NA 0.3634 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045753 Css NA 0.0477 mg/L PBTK NA 50% Rat Human -DTXSID0045753 Css NA 0.2483 mg/L PBTK NA 95% Rat Human -DTXSID0045755 Clint NA 0.1949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045755 Fup NA 0.6134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045755 Vd NA 0.4558 L/kg 1compartment NA NA Human Human +DTXSID0045753 TK.Half.Life NA 6.639 hours 1compartment NA NA Rat Human +DTXSID0045753 Css NA 0.002252 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045753 Css NA 0.01881 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045753 Css NA 0.002328 mg/L PBTK NA 50% Rat Human +DTXSID0045753 Css NA 0.01274 mg/L PBTK NA 95% Rat Human +DTXSID0045755 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045755 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045755 Vd NA 0.5022 L/kg 1compartment NA NA Human Human DTXSID0045755 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045755 TK.Half.Life NA 3.654 hours 1compartment NA NA Human Human -DTXSID0045755 Css NA 0.978 mg/L 3compartmentss NA 50% Human Human -DTXSID0045755 Css NA 6.075 mg/L 3compartmentss NA 95% Human Human -DTXSID0045755 Css NA 0.7147 mg/L PBTK NA 50% Human Human -DTXSID0045755 Css NA 3.767 mg/L PBTK NA 95% Human Human -DTXSID0045755 Clint NA 0.1949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045755 Fup NA 0.6134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045755 Vd NA 0.4714 L/kg 1compartment NA NA Rat Human +DTXSID0045755 TK.Half.Life NA 4.671 hours 1compartment NA NA Human Human +DTXSID0045755 Css NA 0.6486 mg/L 3compartmentss NA 50% Human Human +DTXSID0045755 Css NA 4.167 mg/L 3compartmentss NA 95% Human Human +DTXSID0045755 Css NA 0.486 mg/L PBTK NA 50% Human Human +DTXSID0045755 Css NA 2.591 mg/L PBTK NA 95% Human Human +DTXSID0045755 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045755 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045755 Vd NA 0.5173 L/kg 1compartment NA NA Rat Human DTXSID0045755 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045755 TK.Half.Life NA 1.468 hours 1compartment NA NA Rat Human -DTXSID0045755 Css NA 0.305 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045755 Css NA 1.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045755 Css NA 0.2116 mg/L PBTK NA 50% Rat Human -DTXSID0045755 Css NA 1.068 mg/L PBTK NA 95% Rat Human -DTXSID0045757 Clint NA 20.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045757 Fup NA 0.0174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045757 Vd NA 3.023 L/kg 1compartment NA NA Human Human -DTXSID0045757 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID0045757 TK.Half.Life NA 67.36 hours 1compartment NA NA Human Human -DTXSID0045757 Css NA 2.81 mg/L 3compartmentss NA 50% Human Human -DTXSID0045757 Css NA 19.17 mg/L 3compartmentss NA 95% Human Human -DTXSID0045757 Css NA 1.934 mg/L PBTK NA 50% Human Human -DTXSID0045757 Css NA 12.73 mg/L PBTK NA 95% Human Human -DTXSID0045757 Clint NA 20.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045757 Fup NA 0.0174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045757 Vd NA 2.271 L/kg 1compartment NA NA Rat Human -DTXSID0045757 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID0045757 TK.Half.Life NA 10.66 hours 1compartment NA NA Rat Human -DTXSID0045757 Css NA 1.584 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045757 Css NA 8.706 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045757 Css NA 1.038 mg/L PBTK NA 50% Rat Human -DTXSID0045757 Css NA 5.485 mg/L PBTK NA 95% Rat Human -DTXSID0045759 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045759 Fup NA 0.8575 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045759 Vd NA 0.6518 L/kg 1compartment NA NA Human Human +DTXSID0045755 TK.Half.Life NA 1.639 hours 1compartment NA NA Rat Human +DTXSID0045755 Css NA 0.003371 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045755 Css NA 0.0233 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045755 Css NA 0.002422 mg/L PBTK NA 50% Rat Human +DTXSID0045755 Css NA 0.01388 mg/L PBTK NA 95% Rat Human +DTXSID0045757 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045757 Fup 0.0535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045757 Vd NA 3.036 L/kg 1compartment NA NA Human Human +DTXSID0045757 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID0045757 TK.Half.Life NA 39.72 hours 1compartment NA NA Human Human +DTXSID0045757 Css NA 1.532 mg/L 3compartmentss NA 50% Human Human +DTXSID0045757 Css NA 10.27 mg/L 3compartmentss NA 95% Human Human +DTXSID0045757 Css NA 1.072 mg/L PBTK NA 50% Human Human +DTXSID0045757 Css NA 6.817 mg/L PBTK NA 95% Human Human +DTXSID0045757 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045757 Fup 0.0535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045757 Vd NA 2.294 L/kg 1compartment NA NA Rat Human +DTXSID0045757 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0045757 TK.Half.Life NA 6.658 hours 1compartment NA NA Rat Human +DTXSID0045757 Css NA 0.197 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045757 Css NA 1.102 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045757 Css NA 0.1363 mg/L PBTK NA 50% Rat Human +DTXSID0045757 Css NA 0.7398 mg/L PBTK NA 95% Rat Human +DTXSID0045759 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045759 Fup 0.721 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045759 Vd NA 0.4179 L/kg 1compartment NA NA Human Human DTXSID0045759 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045759 TK.Half.Life NA 4.919 hours 1compartment NA NA Human Human -DTXSID0045759 Css NA 0.982 mg/L 3compartmentss NA 50% Human Human -DTXSID0045759 Css NA 6.004 mg/L 3compartmentss NA 95% Human Human -DTXSID0045759 Css NA 0.786 mg/L PBTK NA 50% Human Human -DTXSID0045759 Css NA 3.766 mg/L PBTK NA 95% Human Human -DTXSID0045759 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045759 Fup NA 0.8575 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045759 Vd NA 0.6902 L/kg 1compartment NA NA Rat Human +DTXSID0045759 TK.Half.Life NA 3.749 hours 1compartment NA NA Human Human +DTXSID0045759 Css NA 0.6462 mg/L 3compartmentss NA 50% Human Human +DTXSID0045759 Css NA 4.143 mg/L 3compartmentss NA 95% Human Human +DTXSID0045759 Css NA 0.47 mg/L PBTK NA 50% Human Human +DTXSID0045759 Css NA 2.571 mg/L PBTK NA 95% Human Human +DTXSID0045759 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045759 Fup 0.721 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045759 Vd NA 0.4428 L/kg 1compartment NA NA Rat Human DTXSID0045759 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045759 TK.Half.Life NA 1.775 hours 1compartment NA NA Rat Human -DTXSID0045759 Css NA 0.2492 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045759 Css NA 1.444 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045759 Css NA 0.1937 mg/L PBTK NA 50% Rat Human -DTXSID0045759 Css NA 0.8573 mg/L PBTK NA 95% Rat Human -DTXSID0045830 Clint NA 0.2938 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045830 Fup NA 0.2872 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045830 Vd NA 0.4739 L/kg 1compartment NA NA Human Human +DTXSID0045759 TK.Half.Life NA 1.354 hours 1compartment NA NA Rat Human +DTXSID0045759 Css NA 0.003399 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045759 Css NA 0.02316 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045759 Css NA 0.002386 mg/L PBTK NA 50% Rat Human +DTXSID0045759 Css NA 0.01348 mg/L PBTK NA 95% Rat Human +DTXSID0045830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045830 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045830 Vd NA 0.4464 L/kg 1compartment NA NA Human Human DTXSID0045830 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045830 TK.Half.Life NA 7.256 hours 1compartment NA NA Human Human -DTXSID0045830 Css NA 1.764 mg/L 3compartmentss NA 50% Human Human -DTXSID0045830 Css NA 7.016 mg/L 3compartmentss NA 95% Human Human -DTXSID0045830 Css NA 1.226 mg/L PBTK NA 50% Human Human -DTXSID0045830 Css NA 4.415 mg/L PBTK NA 95% Human Human -DTXSID0045830 Clint NA 0.2938 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045830 Fup NA 0.2872 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045830 Vd NA 0.4538 L/kg 1compartment NA NA Rat Human +DTXSID0045830 TK.Half.Life NA 0.5581 hours 1compartment NA NA Human Human +DTXSID0045830 Css NA 0.05038 mg/L 3compartmentss NA 50% Human Human +DTXSID0045830 Css NA 0.4047 mg/L 3compartmentss NA 95% Human Human +DTXSID0045830 Css NA 0.03534 mg/L PBTK NA 50% Human Human +DTXSID0045830 Css NA 0.2664 mg/L PBTK NA 95% Human Human +DTXSID0045830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045830 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045830 Vd NA 0.438 L/kg 1compartment NA NA Rat Human DTXSID0045830 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045830 TK.Half.Life NA 2.826 hours 1compartment NA NA Rat Human -DTXSID0045830 Css NA 0.59 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045830 Css NA 2.003 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045830 Css NA 0.3916 mg/L PBTK NA 50% Rat Human -DTXSID0045830 Css NA 1.166 mg/L PBTK NA 95% Rat Human -DTXSID0045832 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0045830 TK.Half.Life NA 0.2856 hours 1compartment NA NA Rat Human +DTXSID0045830 Css NA 0.002368 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045830 Css NA 0.02079 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045830 Css NA 0.001647 mg/L PBTK NA 50% Rat Human +DTXSID0045830 Css NA 0.01324 mg/L PBTK NA 95% Rat Human +DTXSID0045832 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0045832 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0045832 Vd NA 0.6071 L/kg 1compartment NA NA Human Human DTXSID0045832 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0045832 TK.Half.Life NA 5.475 hours 1compartment NA NA Human Human -DTXSID0045832 Css NA 0.9136 mg/L 3compartmentss NA 50% Human Human -DTXSID0045832 Css NA 6.352 mg/L 3compartmentss NA 95% Human Human -DTXSID0045832 Css NA 0.8676 mg/L PBTK NA 50% Human Human -DTXSID0045832 Css NA 4.298 mg/L PBTK NA 95% Human Human -DTXSID0045832 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0045832 Css NA 0.8416 mg/L 3compartmentss NA 50% Human Human +DTXSID0045832 Css NA 4.327 mg/L 3compartmentss NA 95% Human Human +DTXSID0045832 Css NA 0.8416 mg/L PBTK NA 50% Human Human +DTXSID0045832 Css NA 4.327 mg/L PBTK NA 95% Human Human +DTXSID0045832 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0045832 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0045832 Vd NA 0.6069 L/kg 1compartment NA NA Rat Human DTXSID0045832 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0045832 TK.Half.Life NA 1.86 hours 1compartment NA NA Rat Human -DTXSID0045832 Css NA 0.2344 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045832 Css NA 1.729 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045832 Css NA 0.2178 mg/L PBTK NA 50% Rat Human -DTXSID0045832 Css NA 1.071 mg/L PBTK NA 95% Rat Human -DTXSID0045836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045836 Fup NA 0.6861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045836 Vd NA 0.9699 L/kg 1compartment NA NA Human Human +DTXSID0045832 Css NA 0.0491 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045832 Css NA 0.2313 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045832 Css NA 0.05084 mg/L PBTK NA 50% Rat Human +DTXSID0045832 Css NA 0.2396 mg/L PBTK NA 95% Rat Human +DTXSID0045836 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045836 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045836 Vd NA 0.5412 L/kg 1compartment NA NA Human Human DTXSID0045836 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045836 TK.Half.Life NA 9.429 hours 1compartment NA NA Human Human -DTXSID0045836 Css NA 1.07 mg/L 3compartmentss NA 50% Human Human -DTXSID0045836 Css NA 7.16 mg/L 3compartmentss NA 95% Human Human -DTXSID0045836 Css NA 0.9124 mg/L PBTK NA 50% Human Human -DTXSID0045836 Css NA 4.626 mg/L PBTK NA 95% Human Human -DTXSID0045836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045836 Fup NA 0.6861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045836 Vd NA 0.9248 L/kg 1compartment NA NA Rat Human +DTXSID0045836 TK.Half.Life NA 0.7953 hours 1compartment NA NA Human Human +DTXSID0045836 Css NA 0.08524 mg/L 3compartmentss NA 50% Human Human +DTXSID0045836 Css NA 0.6338 mg/L 3compartmentss NA 95% Human Human +DTXSID0045836 Css NA 0.05813 mg/L PBTK NA 50% Human Human +DTXSID0045836 Css NA 0.4118 mg/L PBTK NA 95% Human Human +DTXSID0045836 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045836 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045836 Vd NA 0.5122 L/kg 1compartment NA NA Rat Human DTXSID0045836 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045836 TK.Half.Life NA 2.994 hours 1compartment NA NA Rat Human -DTXSID0045836 Css NA 0.2774 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045836 Css NA 1.844 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045836 Css NA 0.2282 mg/L PBTK NA 50% Rat Human -DTXSID0045836 Css NA 1.104 mg/L PBTK NA 95% Rat Human -DTXSID0045838 Clint NA 0.8889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045838 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045838 Vd NA 1.81 L/kg 1compartment NA NA Human Human -DTXSID0045838 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045838 TK.Half.Life NA 5.023 hours 1compartment NA NA Human Human -DTXSID0045838 Css NA 0.2848 mg/L 3compartmentss NA 50% Human Human -DTXSID0045838 Css NA 2.096 mg/L 3compartmentss NA 95% Human Human -DTXSID0045838 Css NA 0.285 mg/L PBTK NA 50% Human Human -DTXSID0045838 Css NA 1.505 mg/L PBTK NA 95% Human Human -DTXSID0045838 Clint NA 0.8889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045838 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045838 Vd NA 1.855 L/kg 1compartment NA NA Rat Human +DTXSID0045836 TK.Half.Life NA 0.4061 hours 1compartment NA NA Rat Human +DTXSID0045836 Css NA 0.01081 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045836 Css NA 0.06086 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045836 Css NA 0.007317 mg/L PBTK NA 50% Rat Human +DTXSID0045836 Css NA 0.03899 mg/L PBTK NA 95% Rat Human +DTXSID0045838 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045838 Fup 0.741 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045838 Vd NA 1.272 L/kg 1compartment NA NA Human Human +DTXSID0045838 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0045838 TK.Half.Life NA 11.11 hours 1compartment NA NA Human Human +DTXSID0045838 Css NA 0.5071 mg/L 3compartmentss NA 50% Human Human +DTXSID0045838 Css NA 3.632 mg/L 3compartmentss NA 95% Human Human +DTXSID0045838 Css NA 0.469 mg/L PBTK NA 50% Human Human +DTXSID0045838 Css NA 2.416 mg/L PBTK NA 95% Human Human +DTXSID0045838 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045838 Fup 0.741 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045838 Vd NA 1.301 L/kg 1compartment NA NA Rat Human DTXSID0045838 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045838 TK.Half.Life NA 2.447 hours 1compartment NA NA Rat Human -DTXSID0045838 Css NA 0.1022 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045838 Css NA 0.7176 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045838 Css NA 0.1028 mg/L PBTK NA 50% Rat Human -DTXSID0045838 Css NA 0.4598 mg/L PBTK NA 95% Rat Human -DTXSID0045880 Clint NA 21.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045880 Fup NA 0.0847 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045880 Vd NA 2.176 L/kg 1compartment NA NA Human Human +DTXSID0045838 TK.Half.Life NA 3.87 hours 1compartment NA NA Rat Human +DTXSID0045838 Css NA 0.002573 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045838 Css NA 0.01967 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045838 Css NA 0.00232 mg/L PBTK NA 50% Rat Human +DTXSID0045838 Css NA 0.01277 mg/L PBTK NA 95% Rat Human +DTXSID0045880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045880 Fup 0.0905 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045880 Vd NA 2.25 L/kg 1compartment NA NA Human Human DTXSID0045880 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045880 TK.Half.Life NA 5.869 hours 1compartment NA NA Human Human -DTXSID0045880 Css NA 0.281 mg/L 3compartmentss NA 50% Human Human -DTXSID0045880 Css NA 2.267 mg/L 3compartmentss NA 95% Human Human -DTXSID0045880 Css NA 0.2096 mg/L PBTK NA 50% Human Human -DTXSID0045880 Css NA 1.536 mg/L PBTK NA 95% Human Human -DTXSID0045880 Clint NA 21.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045880 Fup NA 0.0847 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045880 Vd NA 1.927 L/kg 1compartment NA NA Rat Human +DTXSID0045880 TK.Half.Life NA 5.71 hours 1compartment NA NA Human Human +DTXSID0045880 Css NA 0.2466 mg/L 3compartmentss NA 50% Human Human +DTXSID0045880 Css NA 1.95 mg/L 3compartmentss NA 95% Human Human +DTXSID0045880 Css NA 0.1862 mg/L PBTK NA 50% Human Human +DTXSID0045880 Css NA 1.365 mg/L PBTK NA 95% Human Human +DTXSID0045880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045880 Fup 0.0905 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045880 Vd NA 1.995 L/kg 1compartment NA NA Rat Human DTXSID0045880 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045880 TK.Half.Life NA 2.743 hours 1compartment NA NA Rat Human -DTXSID0045880 Css NA 0.1573 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045880 Css NA 1.002 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045880 Css NA 0.112 mg/L PBTK NA 50% Rat Human -DTXSID0045880 Css NA 0.6392 mg/L PBTK NA 95% Rat Human -DTXSID0045886 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045886 Fup NA 0.0654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045886 Vd NA 3.493 L/kg 1compartment NA NA Human Human +DTXSID0045880 TK.Half.Life NA 2.64 hours 1compartment NA NA Rat Human +DTXSID0045880 Css NA 0.03161 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045880 Css NA 0.2046 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045880 Css NA 0.02374 mg/L PBTK NA 50% Rat Human +DTXSID0045880 Css NA 0.1359 mg/L PBTK NA 95% Rat Human +DTXSID0045886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045886 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045886 Vd NA 3.901 L/kg 1compartment NA NA Human Human DTXSID0045886 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045886 TK.Half.Life NA 7.182 hours 1compartment NA NA Human Human -DTXSID0045886 Css NA 0.1639 mg/L 3compartmentss NA 50% Human Human -DTXSID0045886 Css NA 1.247 mg/L 3compartmentss NA 95% Human Human -DTXSID0045886 Css NA 0.1464 mg/L PBTK NA 50% Human Human -DTXSID0045886 Css NA 0.9928 mg/L PBTK NA 95% Human Human -DTXSID0045886 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045886 Fup NA 0.0654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045886 Vd NA 3.139 L/kg 1compartment NA NA Rat Human +DTXSID0045886 TK.Half.Life NA 4.271 hours 1compartment NA NA Human Human +DTXSID0045886 Css NA 0.04682 mg/L 3compartmentss NA 50% Human Human +DTXSID0045886 Css NA 0.3819 mg/L 3compartmentss NA 95% Human Human +DTXSID0045886 Css NA 0.05469 mg/L PBTK NA 50% Human Human +DTXSID0045886 Css NA 0.3755 mg/L PBTK NA 95% Human Human +DTXSID0045886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045886 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045886 Vd NA 3.878 L/kg 1compartment NA NA Rat Human DTXSID0045886 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045886 TK.Half.Life NA 2.847 hours 1compartment NA NA Rat Human -DTXSID0045886 Css NA 0.08962 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045886 Css NA 0.5539 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045886 Css NA 0.07798 mg/L PBTK NA 50% Rat Human -DTXSID0045886 Css NA 0.4314 mg/L PBTK NA 95% Rat Human -DTXSID0045888 Clint NA 0.02208 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045888 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045888 Vd NA 0.8575 L/kg 1compartment NA NA Human Human +DTXSID0045886 TK.Half.Life NA 2.3 hours 1compartment NA NA Rat Human +DTXSID0045886 Css NA 0.005702 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045886 Css NA 0.03803 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045886 Css NA 0.006922 mg/L PBTK NA 50% Rat Human +DTXSID0045886 Css NA 0.03741 mg/L PBTK NA 95% Rat Human +DTXSID0045888 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045888 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045888 Vd NA 0.6073 L/kg 1compartment NA NA Human Human DTXSID0045888 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045888 TK.Half.Life NA 5.369 hours 1compartment NA NA Human Human -DTXSID0045888 Css NA 0.7701 mg/L 3compartmentss NA 50% Human Human -DTXSID0045888 Css NA 5.117 mg/L 3compartmentss NA 95% Human Human -DTXSID0045888 Css NA 0.6638 mg/L PBTK NA 50% Human Human -DTXSID0045888 Css NA 3.326 mg/L PBTK NA 95% Human Human -DTXSID0045888 Clint NA 0.02208 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045888 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045888 Vd NA 0.8812 L/kg 1compartment NA NA Rat Human +DTXSID0045888 TK.Half.Life NA 7.016 hours 1compartment NA NA Human Human +DTXSID0045888 Css NA 1.299 mg/L 3compartmentss NA 50% Human Human +DTXSID0045888 Css NA 8.693 mg/L 3compartmentss NA 95% Human Human +DTXSID0045888 Css NA 1.004 mg/L PBTK NA 50% Human Human +DTXSID0045888 Css NA 5.443 mg/L PBTK NA 95% Human Human +DTXSID0045888 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045888 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045888 Vd NA 0.6225 L/kg 1compartment NA NA Rat Human DTXSID0045888 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045888 TK.Half.Life NA 1.911 hours 1compartment NA NA Rat Human -DTXSID0045888 Css NA 0.2014 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045888 Css NA 1.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045888 Css NA 0.1698 mg/L PBTK NA 50% Rat Human -DTXSID0045888 Css NA 0.7648 mg/L PBTK NA 95% Rat Human +DTXSID0045888 TK.Half.Life NA 2.448 hours 1compartment NA NA Rat Human +DTXSID0045888 Css NA 0.08014 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045888 Css NA 0.5106 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045888 Css NA 0.0613 mg/L PBTK NA 50% Rat Human +DTXSID0045888 Css NA 0.3068 mg/L PBTK NA 95% Rat Human DTXSID0045961 Clint NA 15.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0045961 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045961 Vd NA 2.432 L/kg 1compartment NA NA Human Human +DTXSID0045961 Vd NA 2.164 L/kg 1compartment NA NA Human Human DTXSID0045961 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045961 TK.Half.Life NA 1.512 hours 1compartment NA NA Human Human -DTXSID0045961 Css NA 0.02535 mg/L 3compartmentss NA 50% Human Human -DTXSID0045961 Css NA 0.3226 mg/L 3compartmentss NA 95% Human Human -DTXSID0045961 Css NA 0.0274 mg/L PBTK NA 50% Human Human -DTXSID0045961 Css NA 0.287 mg/L PBTK NA 95% Human Human +DTXSID0045961 TK.Half.Life NA 1.38 hours 1compartment NA NA Human Human +DTXSID0045961 Css NA 0.02364 mg/L 3compartmentss NA 50% Human Human +DTXSID0045961 Css NA 0.3201 mg/L 3compartmentss NA 95% Human Human +DTXSID0045961 Css NA 0.02474 mg/L PBTK NA 50% Human Human +DTXSID0045961 Css NA 0.264 mg/L PBTK NA 95% Human Human DTXSID0045961 Clint NA 15.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0045961 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045961 Vd NA 2.469 L/kg 1compartment NA NA Rat Human +DTXSID0045961 Vd NA 2.198 L/kg 1compartment NA NA Rat Human DTXSID0045961 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045961 TK.Half.Life NA 0.7775 hours 1compartment NA NA Rat Human -DTXSID0045961 Css NA 0.01234 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045961 Css NA 0.1261 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045961 Css NA 0.01356 mg/L PBTK NA 50% Rat Human -DTXSID0045961 Css NA 0.09972 mg/L PBTK NA 95% Rat Human -DTXSID0045963 Clint NA 264.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045963 Fup NA 0.3805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045963 Vd NA 1.984 L/kg 1compartment NA NA Human Human +DTXSID0045961 TK.Half.Life NA 0.706 hours 1compartment NA NA Rat Human +DTXSID0045961 Css NA 0.002711 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045961 Css NA 0.02758 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045961 Css NA 0.002976 mg/L PBTK NA 50% Rat Human +DTXSID0045961 Css NA 0.02315 mg/L PBTK NA 95% Rat Human +DTXSID0045963 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045963 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045963 Vd NA 1.701 L/kg 1compartment NA NA Human Human DTXSID0045963 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045963 TK.Half.Life NA 1.473 hours 1compartment NA NA Human Human -DTXSID0045963 Css NA 0.006455 mg/L 3compartmentss NA 50% Human Human -DTXSID0045963 Css NA 0.04678 mg/L 3compartmentss NA 95% Human Human -DTXSID0045963 Css NA 0.005049 mg/L PBTK NA 50% Human Human -DTXSID0045963 Css NA 0.03414 mg/L PBTK NA 95% Human Human -DTXSID0045963 Clint NA 264.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045963 Fup NA 0.3805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045963 Vd NA 1.577 L/kg 1compartment NA NA Rat Human +DTXSID0045963 TK.Half.Life NA 2.615 hours 1compartment NA NA Human Human +DTXSID0045963 Css NA 0.0947 mg/L 3compartmentss NA 50% Human Human +DTXSID0045963 Css NA 0.6488 mg/L 3compartmentss NA 95% Human Human +DTXSID0045963 Css NA 0.0709 mg/L PBTK NA 50% Human Human +DTXSID0045963 Css NA 0.4474 mg/L PBTK NA 95% Human Human +DTXSID0045963 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045963 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045963 Vd NA 1.348 L/kg 1compartment NA NA Rat Human DTXSID0045963 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045963 TK.Half.Life NA 0.5074 hours 1compartment NA NA Rat Human -DTXSID0045963 Css NA 0.003526 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045963 Css NA 0.02157 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045963 Css NA 0.002688 mg/L PBTK NA 50% Rat Human -DTXSID0045963 Css NA 0.01515 mg/L PBTK NA 95% Rat Human -DTXSID0045965 Clint NA 39.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045965 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045965 Vd NA 2.777 L/kg 1compartment NA NA Human Human +DTXSID0045963 TK.Half.Life NA 0.9842 hours 1compartment NA NA Rat Human +DTXSID0045963 Css NA 0.01182 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045963 Css NA 0.06262 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045963 Css NA 0.008869 mg/L PBTK NA 50% Rat Human +DTXSID0045963 Css NA 0.04351 mg/L PBTK NA 95% Rat Human +DTXSID0045965 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045965 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045965 Vd NA 3.394 L/kg 1compartment NA NA Human Human DTXSID0045965 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0045965 TK.Half.Life NA 8.738 hours 1compartment NA NA Human Human -DTXSID0045965 Css NA 0.3442 mg/L 3compartmentss NA 50% Human Human -DTXSID0045965 Css NA 2.515 mg/L 3compartmentss NA 95% Human Human -DTXSID0045965 Css NA 0.244 mg/L PBTK NA 50% Human Human -DTXSID0045965 Css NA 1.669 mg/L PBTK NA 95% Human Human -DTXSID0045965 Clint NA 39.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045965 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045965 Vd NA 2.193 L/kg 1compartment NA NA Rat Human +DTXSID0045965 TK.Half.Life NA 13.13 hours 1compartment NA NA Human Human +DTXSID0045965 Css NA 0.342 mg/L 3compartmentss NA 50% Human Human +DTXSID0045965 Css NA 2.389 mg/L 3compartmentss NA 95% Human Human +DTXSID0045965 Css NA 0.2641 mg/L PBTK NA 50% Human Human +DTXSID0045965 Css NA 1.721 mg/L PBTK NA 95% Human Human +DTXSID0045965 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045965 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045965 Vd NA 2.702 L/kg 1compartment NA NA Rat Human DTXSID0045965 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045965 TK.Half.Life NA 2.518 hours 1compartment NA NA Rat Human -DTXSID0045965 Css NA 0.1903 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045965 Css NA 1.186 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045965 Css NA 0.1287 mg/L PBTK NA 50% Rat Human -DTXSID0045965 Css NA 0.7595 mg/L PBTK NA 95% Rat Human -DTXSID0045967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045967 Fup NA 0.218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0045967 Vd NA 0.3759 L/kg 1compartment NA NA Human Human +DTXSID0045965 TK.Half.Life NA 2.679 hours 1compartment NA NA Rat Human +DTXSID0045965 Css NA 0.04366 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045965 Css NA 0.233 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045965 Css NA 0.03386 mg/L PBTK NA 50% Rat Human +DTXSID0045965 Css NA 0.17 mg/L PBTK NA 95% Rat Human +DTXSID0045967 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045967 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0045967 Vd NA 0.2997 L/kg 1compartment NA NA Human Human DTXSID0045967 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0045967 TK.Half.Life NA 11.19 hours 1compartment NA NA Human Human -DTXSID0045967 Css NA 3.722 mg/L 3compartmentss NA 50% Human Human -DTXSID0045967 Css NA 13.42 mg/L 3compartmentss NA 95% Human Human -DTXSID0045967 Css NA 2.441 mg/L PBTK NA 50% Human Human -DTXSID0045967 Css NA 8.183 mg/L PBTK NA 95% Human Human -DTXSID0045967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045967 Fup NA 0.218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0045967 Vd NA 0.3687 L/kg 1compartment NA NA Rat Human +DTXSID0045967 TK.Half.Life NA 11.42 hours 1compartment NA NA Human Human +DTXSID0045967 Css NA 2.656 mg/L 3compartmentss NA 50% Human Human +DTXSID0045967 Css NA 10.26 mg/L 3compartmentss NA 95% Human Human +DTXSID0045967 Css NA 1.69 mg/L PBTK NA 50% Human Human +DTXSID0045967 Css NA 6.148 mg/L PBTK NA 95% Human Human +DTXSID0045967 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045967 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0045967 Vd NA 0.2959 L/kg 1compartment NA NA Rat Human DTXSID0045967 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0045967 TK.Half.Life NA 3.731 hours 1compartment NA NA Rat Human -DTXSID0045967 Css NA 1.036 mg/L 3compartmentss NA 50% Rat Human -DTXSID0045967 Css NA 3.075 mg/L 3compartmentss NA 95% Rat Human -DTXSID0045967 Css NA 0.6393 mg/L PBTK NA 50% Rat Human -DTXSID0045967 Css NA 1.747 mg/L PBTK NA 95% Rat Human -DTXSID0046010 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046010 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046010 Vd NA 0.8051 L/kg 1compartment NA NA Human Human +DTXSID0045967 TK.Half.Life NA 3.838 hours 1compartment NA NA Rat Human +DTXSID0045967 Css NA 0.01446 mg/L 3compartmentss NA 50% Rat Human +DTXSID0045967 Css NA 0.05661 mg/L 3compartmentss NA 95% Rat Human +DTXSID0045967 Css NA 0.008638 mg/L PBTK NA 50% Rat Human +DTXSID0045967 Css NA 0.03232 mg/L PBTK NA 95% Rat Human +DTXSID0046010 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046010 Fup 0.738 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046010 Vd NA 0.6705 L/kg 1compartment NA NA Human Human DTXSID0046010 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046010 TK.Half.Life NA 5.216 hours 1compartment NA NA Human Human -DTXSID0046010 Css NA 0.821 mg/L 3compartmentss NA 50% Human Human -DTXSID0046010 Css NA 5.727 mg/L 3compartmentss NA 95% Human Human -DTXSID0046010 Css NA 0.695 mg/L PBTK NA 50% Human Human -DTXSID0046010 Css NA 3.713 mg/L PBTK NA 95% Human Human -DTXSID0046010 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046010 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046010 Vd NA 0.8362 L/kg 1compartment NA NA Rat Human +DTXSID0046010 TK.Half.Life NA 5.884 hours 1compartment NA NA Human Human +DTXSID0046010 Css NA 1.031 mg/L 3compartmentss NA 50% Human Human +DTXSID0046010 Css NA 6.745 mg/L 3compartmentss NA 95% Human Human +DTXSID0046010 Css NA 0.8322 mg/L PBTK NA 50% Human Human +DTXSID0046010 Css NA 4.239 mg/L PBTK NA 95% Human Human +DTXSID0046010 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046010 Fup 0.738 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046010 Vd NA 0.6958 L/kg 1compartment NA NA Rat Human DTXSID0046010 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046010 TK.Half.Life NA 1.844 hours 1compartment NA NA Rat Human -DTXSID0046010 Css NA 0.2064 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046010 Css NA 1.312 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046010 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0046010 Css NA 0.7918 mg/L PBTK NA 95% Rat Human -DTXSID0046012 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046012 Fup NA 0.8623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046012 Vd NA 0.4447 L/kg 1compartment NA NA Human Human +DTXSID0046010 TK.Half.Life NA 2.079 hours 1compartment NA NA Rat Human +DTXSID0046010 Css NA 0.06202 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046010 Css NA 0.3846 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046010 Css NA 0.04981 mg/L PBTK NA 50% Rat Human +DTXSID0046010 Css NA 0.2349 mg/L PBTK NA 95% Rat Human +DTXSID0046012 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046012 Fup 0.819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046012 Vd NA 0.4667 L/kg 1compartment NA NA Human Human DTXSID0046012 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046012 TK.Half.Life NA 3.336 hours 1compartment NA NA Human Human -DTXSID0046012 Css NA 1.064 mg/L 3compartmentss NA 50% Human Human -DTXSID0046012 Css NA 5.815 mg/L 3compartmentss NA 95% Human Human -DTXSID0046012 Css NA 0.7821 mg/L PBTK NA 50% Human Human -DTXSID0046012 Css NA 3.616 mg/L PBTK NA 95% Human Human -DTXSID0046012 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046012 Fup NA 0.8623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046012 Vd NA 0.4718 L/kg 1compartment NA NA Rat Human +DTXSID0046012 TK.Half.Life NA 3.687 hours 1compartment NA NA Human Human +DTXSID0046012 Css NA 0.9356 mg/L 3compartmentss NA 50% Human Human +DTXSID0046012 Css NA 5.319 mg/L 3compartmentss NA 95% Human Human +DTXSID0046012 Css NA 0.6964 mg/L PBTK NA 50% Human Human +DTXSID0046012 Css NA 3.38 mg/L PBTK NA 95% Human Human +DTXSID0046012 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046012 Fup 0.819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046012 Vd NA 0.488 L/kg 1compartment NA NA Rat Human DTXSID0046012 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046012 TK.Half.Life NA 1.206 hours 1compartment NA NA Rat Human -DTXSID0046012 Css NA 0.2748 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046012 Css NA 1.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046012 Css NA 0.1939 mg/L PBTK NA 50% Rat Human -DTXSID0046012 Css NA 0.8497 mg/L PBTK NA 95% Rat Human +DTXSID0046012 TK.Half.Life NA 1.314 hours 1compartment NA NA Rat Human +DTXSID0046012 Css NA 0.02432 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046012 Css NA 0.1598 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046012 Css NA 0.01743 mg/L PBTK NA 50% Rat Human +DTXSID0046012 Css NA 0.09869 mg/L PBTK NA 95% Rat Human DTXSID0046016 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0046016 Fup NA 0.889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046016 Vd NA 1.713 L/kg 1compartment NA NA Human Human +DTXSID0046016 Vd NA 1.502 L/kg 1compartment NA NA Human Human DTXSID0046016 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0046016 TK.Half.Life NA 12.47 hours 1compartment NA NA Human Human -DTXSID0046016 Css NA 0.7824 mg/L 3compartmentss NA 50% Human Human -DTXSID0046016 Css NA 4.877 mg/L 3compartmentss NA 95% Human Human -DTXSID0046016 Css NA 0.767 mg/L PBTK NA 50% Human Human -DTXSID0046016 Css NA 3.424 mg/L PBTK NA 95% Human Human +DTXSID0046016 TK.Half.Life NA 10.93 hours 1compartment NA NA Human Human +DTXSID0046016 Css NA 0.6847 mg/L 3compartmentss NA 50% Human Human +DTXSID0046016 Css NA 4.216 mg/L 3compartmentss NA 95% Human Human +DTXSID0046016 Css NA 0.6563 mg/L PBTK NA 50% Human Human +DTXSID0046016 Css NA 2.879 mg/L PBTK NA 95% Human Human DTXSID0046016 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0046016 Fup NA 0.889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046016 Vd NA 1.751 L/kg 1compartment NA NA Rat Human +DTXSID0046016 Vd NA 1.546 L/kg 1compartment NA NA Rat Human DTXSID0046016 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046016 TK.Half.Life NA 4.343 hours 1compartment NA NA Rat Human -DTXSID0046016 Css NA 0.1972 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046016 Css NA 1.236 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046016 Css NA 0.1916 mg/L PBTK NA 50% Rat Human -DTXSID0046016 Css NA 0.796 mg/L PBTK NA 95% Rat Human -DTXSID0046060 Clint NA 50.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046060 Fup NA 0.2759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046060 Vd NA 2.932 L/kg 1compartment NA NA Human Human +DTXSID0046016 TK.Half.Life NA 3.834 hours 1compartment NA NA Rat Human +DTXSID0046016 Css NA 0.01267 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046016 Css NA 0.1006 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046016 Css NA 0.01184 mg/L PBTK NA 50% Rat Human +DTXSID0046016 Css NA 0.07084 mg/L PBTK NA 95% Rat Human +DTXSID0046060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046060 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046060 Vd NA 2.966 L/kg 1compartment NA NA Human Human DTXSID0046060 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046060 TK.Half.Life NA 5.373 hours 1compartment NA NA Human Human -DTXSID0046060 Css NA 0.1288 mg/L 3compartmentss NA 50% Human Human -DTXSID0046060 Css NA 0.8538 mg/L 3compartmentss NA 95% Human Human -DTXSID0046060 Css NA 0.0954 mg/L PBTK NA 50% Human Human -DTXSID0046060 Css NA 0.6082 mg/L PBTK NA 95% Human Human -DTXSID0046060 Clint NA 50.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046060 Fup NA 0.2759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046060 Vd NA 2.251 L/kg 1compartment NA NA Rat Human +DTXSID0046060 TK.Half.Life NA 9.227 hours 1compartment NA NA Human Human +DTXSID0046060 Css NA 0.2692 mg/L 3compartmentss NA 50% Human Human +DTXSID0046060 Css NA 1.721 mg/L 3compartmentss NA 95% Human Human +DTXSID0046060 Css NA 0.2008 mg/L PBTK NA 50% Human Human +DTXSID0046060 Css NA 1.232 mg/L PBTK NA 95% Human Human +DTXSID0046060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046060 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046060 Vd NA 2.281 L/kg 1compartment NA NA Rat Human DTXSID0046060 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046060 TK.Half.Life NA 1.347 hours 1compartment NA NA Rat Human -DTXSID0046060 Css NA 0.07135 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046060 Css NA 0.361 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046060 Css NA 0.05084 mg/L PBTK NA 50% Rat Human -DTXSID0046060 Css NA 0.2488 mg/L PBTK NA 95% Rat Human -DTXSID0046062 Clint NA 1.251 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046062 Fup NA 0.0336 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046062 Vd NA 2.166 L/kg 1compartment NA NA Human Human -DTXSID0046062 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID0046062 TK.Half.Life NA 106 hours 1compartment NA NA Human Human -DTXSID0046062 Css NA 7.533 mg/L 3compartmentss NA 50% Human Human -DTXSID0046062 Css NA 40.61 mg/L 3compartmentss NA 95% Human Human -DTXSID0046062 Css NA 5.239 mg/L PBTK NA 50% Human Human -DTXSID0046062 Css NA 25.61 mg/L PBTK NA 95% Human Human -DTXSID0046062 Clint NA 1.251 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046062 Fup NA 0.0336 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046062 Vd NA 1.82 L/kg 1compartment NA NA Rat Human -DTXSID0046062 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID0046062 TK.Half.Life NA 39.72 hours 1compartment NA NA Rat Human -DTXSID0046062 Css NA 3.588 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046062 Css NA 15.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046062 Css NA 2.375 mg/L PBTK NA 50% Rat Human -DTXSID0046062 Css NA 8.955 mg/L PBTK NA 95% Rat Human +DTXSID0046060 TK.Half.Life NA 2.05 hours 1compartment NA NA Rat Human +DTXSID0046060 Css NA 0.03404 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046060 Css NA 0.169 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046060 Css NA 0.0254 mg/L PBTK NA 50% Rat Human +DTXSID0046060 Css NA 0.1209 mg/L PBTK NA 95% Rat Human +DTXSID0046062 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046062 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046062 Vd NA 3.705 L/kg 1compartment NA NA Human Human +DTXSID0046062 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0046062 TK.Half.Life NA 20.69 hours 1compartment NA NA Human Human +DTXSID0046062 Css NA 0.4852 mg/L 3compartmentss NA 50% Human Human +DTXSID0046062 Css NA 2.996 mg/L 3compartmentss NA 95% Human Human +DTXSID0046062 Css NA 0.4295 mg/L PBTK NA 50% Human Human +DTXSID0046062 Css NA 2.447 mg/L PBTK NA 95% Human Human +DTXSID0046062 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046062 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046062 Vd NA 3.181 L/kg 1compartment NA NA Rat Human +DTXSID0046062 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0046062 TK.Half.Life NA 5.622 hours 1compartment NA NA Rat Human +DTXSID0046062 Css NA 0.05881 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046062 Css NA 0.2688 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046062 Css NA 0.05314 mg/L PBTK NA 50% Rat Human +DTXSID0046062 Css NA 0.224 mg/L PBTK NA 95% Rat Human DTXSID0046064 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0046064 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0046064 Vd NA 0.7058 L/kg 1compartment NA NA Human Human DTXSID0046064 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0046064 TK.Half.Life NA 4.569 hours 1compartment NA NA Human Human -DTXSID0046064 Css NA 0.8454 mg/L 3compartmentss NA 50% Human Human -DTXSID0046064 Css NA 5.573 mg/L 3compartmentss NA 95% Human Human -DTXSID0046064 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID0046064 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID0046064 Css NA 0.7126 mg/L 3compartmentss NA 50% Human Human +DTXSID0046064 Css NA 5.068 mg/L 3compartmentss NA 95% Human Human +DTXSID0046064 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID0046064 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID0046064 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0046064 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0046064 Vd NA 0.7547 L/kg 1compartment NA NA Rat Human DTXSID0046064 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0046064 TK.Half.Life NA 1.664 hours 1compartment NA NA Rat Human -DTXSID0046064 Css NA 0.2123 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046064 Css NA 1.338 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046064 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0046064 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0046066 Clint NA 12.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046066 Fup NA 0.2136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046066 Vd NA 0.3858 L/kg 1compartment NA NA Human Human +DTXSID0046064 Css NA 0.01308 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046064 Css NA 0.1001 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046064 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID0046064 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID0046066 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046066 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046066 Vd NA 0.5219 L/kg 1compartment NA NA Human Human DTXSID0046066 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046066 TK.Half.Life NA 0.8176 hours 1compartment NA NA Human Human -DTXSID0046066 Css NA 0.1773 mg/L 3compartmentss NA 50% Human Human -DTXSID0046066 Css NA 1.141 mg/L 3compartmentss NA 95% Human Human -DTXSID0046066 Css NA 0.1184 mg/L PBTK NA 50% Human Human -DTXSID0046066 Css NA 0.7267 mg/L PBTK NA 95% Human Human -DTXSID0046066 Clint NA 12.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046066 Fup NA 0.2136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046066 Vd NA 0.3891 L/kg 1compartment NA NA Rat Human +DTXSID0046066 TK.Half.Life NA 0.5929 hours 1compartment NA NA Human Human +DTXSID0046066 Css NA 0.02116 mg/L 3compartmentss NA 50% Human Human +DTXSID0046066 Css NA 0.2208 mg/L 3compartmentss NA 95% Human Human +DTXSID0046066 Css NA 0.01564 mg/L PBTK NA 50% Human Human +DTXSID0046066 Css NA 0.1448 mg/L PBTK NA 95% Human Human +DTXSID0046066 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046066 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046066 Vd NA 0.5291 L/kg 1compartment NA NA Rat Human DTXSID0046066 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046066 TK.Half.Life NA 0.4722 hours 1compartment NA NA Rat Human -DTXSID0046066 Css NA 0.09627 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046066 Css NA 0.4672 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046066 Css NA 0.06104 mg/L PBTK NA 50% Rat Human -DTXSID0046066 Css NA 0.2748 mg/L PBTK NA 95% Rat Human -DTXSID0046143 Clint NA 45.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046143 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046143 Vd NA 2.56 L/kg 1compartment NA NA Human Human -DTXSID0046143 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046143 TK.Half.Life NA 13.62 hours 1compartment NA NA Human Human -DTXSID0046143 Css NA 0.6693 mg/L 3compartmentss NA 50% Human Human -DTXSID0046143 Css NA 4.897 mg/L 3compartmentss NA 95% Human Human -DTXSID0046143 Css NA 0.4468 mg/L PBTK NA 50% Human Human -DTXSID0046143 Css NA 3.111 mg/L PBTK NA 95% Human Human -DTXSID0046143 Clint NA 45.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046143 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046143 Vd NA 1.914 L/kg 1compartment NA NA Rat Human -DTXSID0046143 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046143 TK.Half.Life NA 3.38 hours 1compartment NA NA Rat Human -DTXSID0046143 Css NA 0.3784 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046143 Css NA 2.142 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046143 Css NA 0.2396 mg/L PBTK NA 50% Rat Human -DTXSID0046143 Css NA 1.298 mg/L PBTK NA 95% Rat Human -DTXSID0046145 Clint NA 36.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046145 Fup NA 0.066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046145 Vd NA 2.703 L/kg 1compartment NA NA Human Human +DTXSID0046066 TK.Half.Life NA 0.3105 hours 1compartment NA NA Rat Human +DTXSID0046066 Css NA 0.0001888 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046066 Css NA 0.001926 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046066 Css NA 0.0001342 mg/L PBTK NA 50% Rat Human +DTXSID0046066 Css NA 0.001261 mg/L PBTK NA 95% Rat Human +DTXSID0046143 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046143 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046143 Vd NA 1.798 L/kg 1compartment NA NA Human Human +DTXSID0046143 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0046143 TK.Half.Life NA 25.58 hours 1compartment NA NA Human Human +DTXSID0046143 Css NA 2.226 mg/L 3compartmentss NA 50% Human Human +DTXSID0046143 Css NA 18.48 mg/L 3compartmentss NA 95% Human Human +DTXSID0046143 Css NA 1.405 mg/L PBTK NA 50% Human Human +DTXSID0046143 Css NA 11.34 mg/L PBTK NA 95% Human Human +DTXSID0046143 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046143 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046143 Vd NA 1.33 L/kg 1compartment NA NA Rat Human +DTXSID0046143 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0046143 TK.Half.Life NA 8.899 hours 1compartment NA NA Rat Human +DTXSID0046143 Css NA 0.2898 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046143 Css NA 2.094 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046143 Css NA 0.1779 mg/L PBTK NA 50% Rat Human +DTXSID0046143 Css NA 1.223 mg/L PBTK NA 95% Rat Human +DTXSID0046145 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046145 Fup 0.0708 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046145 Vd NA 3.035 L/kg 1compartment NA NA Human Human DTXSID0046145 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046145 TK.Half.Life NA 4.151 hours 1compartment NA NA Human Human -DTXSID0046145 Css NA 0.1196 mg/L 3compartmentss NA 50% Human Human -DTXSID0046145 Css NA 1.022 mg/L 3compartmentss NA 95% Human Human -DTXSID0046145 Css NA 0.09636 mg/L PBTK NA 50% Human Human -DTXSID0046145 Css NA 0.7262 mg/L PBTK NA 95% Human Human -DTXSID0046145 Clint NA 36.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046145 Fup NA 0.066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046145 Vd NA 2.483 L/kg 1compartment NA NA Rat Human +DTXSID0046145 TK.Half.Life NA 6.006 hours 1compartment NA NA Human Human +DTXSID0046145 Css NA 0.157 mg/L 3compartmentss NA 50% Human Human +DTXSID0046145 Css NA 1.215 mg/L 3compartmentss NA 95% Human Human +DTXSID0046145 Css NA 0.1318 mg/L PBTK NA 50% Human Human +DTXSID0046145 Css NA 0.8942 mg/L PBTK NA 95% Human Human +DTXSID0046145 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046145 Fup 0.0708 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046145 Vd NA 2.738 L/kg 1compartment NA NA Rat Human DTXSID0046145 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046145 TK.Half.Life NA 1.941 hours 1compartment NA NA Rat Human -DTXSID0046145 Css NA 0.0662 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046145 Css NA 0.4569 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046145 Css NA 0.05182 mg/L PBTK NA 50% Rat Human -DTXSID0046145 Css NA 0.3168 mg/L PBTK NA 95% Rat Human -DTXSID0046147 Clint NA 7.822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046147 Fup NA 0.6707 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046147 Vd NA 2.661 L/kg 1compartment NA NA Human Human -DTXSID0046147 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046147 TK.Half.Life NA 2.869 hours 1compartment NA NA Human Human -DTXSID0046147 Css NA 0.0642 mg/L 3compartmentss NA 50% Human Human -DTXSID0046147 Css NA 0.6834 mg/L 3compartmentss NA 95% Human Human -DTXSID0046147 Css NA 0.07005 mg/L PBTK NA 50% Human Human -DTXSID0046147 Css NA 0.5286 mg/L PBTK NA 95% Human Human -DTXSID0046147 Clint NA 7.822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046147 Fup NA 0.6707 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046147 Vd NA 2.702 L/kg 1compartment NA NA Rat Human +DTXSID0046145 TK.Half.Life NA 2.605 hours 1compartment NA NA Rat Human +DTXSID0046145 Css NA 0.01986 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046145 Css NA 0.1255 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046145 Css NA 0.01675 mg/L PBTK NA 50% Rat Human +DTXSID0046145 Css NA 0.09681 mg/L PBTK NA 95% Rat Human +DTXSID0046147 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046147 Fup 0.773 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046147 Vd NA 3.086 L/kg 1compartment NA NA Human Human +DTXSID0046147 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0046147 TK.Half.Life NA 26.01 hours 1compartment NA NA Human Human +DTXSID0046147 Css NA 0.6817 mg/L 3compartmentss NA 50% Human Human +DTXSID0046147 Css NA 5.623 mg/L 3compartmentss NA 95% Human Human +DTXSID0046147 Css NA 0.8022 mg/L PBTK NA 50% Human Human +DTXSID0046147 Css NA 4.106 mg/L PBTK NA 95% Human Human +DTXSID0046147 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046147 Fup 0.773 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046147 Vd NA 3.141 L/kg 1compartment NA NA Rat Human DTXSID0046147 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046147 TK.Half.Life NA 1.605 hours 1compartment NA NA Rat Human -DTXSID0046147 Css NA 0.03031 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046147 Css NA 0.2869 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046147 Css NA 0.03338 mg/L PBTK NA 50% Rat Human -DTXSID0046147 Css NA 0.2034 mg/L PBTK NA 95% Rat Human -DTXSID0046191 Clint NA 40.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046191 Fup NA 0.4614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046191 Vd NA 2.813 L/kg 1compartment NA NA Human Human +DTXSID0046147 TK.Half.Life NA 8.974 hours 1compartment NA NA Rat Human +DTXSID0046147 Css NA 0.03921 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046147 Css NA 0.3113 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046147 Css NA 0.0481 mg/L PBTK NA 50% Rat Human +DTXSID0046147 Css NA 0.2194 mg/L PBTK NA 95% Rat Human +DTXSID0046191 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046191 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046191 Vd NA 2.518 L/kg 1compartment NA NA Human Human DTXSID0046191 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046191 TK.Half.Life NA 2.324 hours 1compartment NA NA Human Human -DTXSID0046191 Css NA 0.02709 mg/L 3compartmentss NA 50% Human Human -DTXSID0046191 Css NA 0.2202 mg/L 3compartmentss NA 95% Human Human -DTXSID0046191 Css NA 0.02576 mg/L PBTK NA 50% Human Human -DTXSID0046191 Css NA 0.1785 mg/L PBTK NA 95% Human Human -DTXSID0046191 Clint NA 40.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046191 Fup NA 0.4614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046191 Vd NA 2.527 L/kg 1compartment NA NA Rat Human +DTXSID0046191 TK.Half.Life NA 2.905 hours 1compartment NA NA Human Human +DTXSID0046191 Css NA 0.05486 mg/L 3compartmentss NA 50% Human Human +DTXSID0046191 Css NA 0.4113 mg/L 3compartmentss NA 95% Human Human +DTXSID0046191 Css NA 0.04979 mg/L PBTK NA 50% Human Human +DTXSID0046191 Css NA 0.327 mg/L PBTK NA 95% Human Human +DTXSID0046191 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046191 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046191 Vd NA 2.261 L/kg 1compartment NA NA Rat Human DTXSID0046191 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046191 TK.Half.Life NA 0.9458 hours 1compartment NA NA Rat Human -DTXSID0046191 Css NA 0.01435 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046191 Css NA 0.09312 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046191 Css NA 0.01344 mg/L PBTK NA 50% Rat Human -DTXSID0046191 Css NA 0.07491 mg/L PBTK NA 95% Rat Human -DTXSID0046193 Clint NA 9.254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046193 Fup NA 0.4877 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046193 Vd NA 5.355 L/kg 1compartment NA NA Human Human +DTXSID0046191 TK.Half.Life NA 1.246 hours 1compartment NA NA Rat Human +DTXSID0046191 Css NA 0.006714 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046191 Css NA 0.03996 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046191 Css NA 0.006212 mg/L PBTK NA 50% Rat Human +DTXSID0046191 Css NA 0.03164 mg/L PBTK NA 95% Rat Human +DTXSID0046193 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046193 Fup 0.324 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046193 Vd NA 3.994 L/kg 1compartment NA NA Human Human DTXSID0046193 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046193 TK.Half.Life NA 4.624 hours 1compartment NA NA Human Human -DTXSID0046193 Css NA 0.03152 mg/L 3compartmentss NA 50% Human Human -DTXSID0046193 Css NA 0.3697 mg/L 3compartmentss NA 95% Human Human -DTXSID0046193 Css NA 0.05612 mg/L PBTK NA 50% Human Human -DTXSID0046193 Css NA 0.4039 mg/L PBTK NA 95% Human Human -DTXSID0046193 Clint NA 9.254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046193 Fup NA 0.4877 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046193 Vd NA 5.405 L/kg 1compartment NA NA Rat Human +DTXSID0046193 TK.Half.Life NA 3.005 hours 1compartment NA NA Human Human +DTXSID0046193 Css NA 0.0235 mg/L 3compartmentss NA 50% Human Human +DTXSID0046193 Css NA 0.2272 mg/L 3compartmentss NA 95% Human Human +DTXSID0046193 Css NA 0.03268 mg/L PBTK NA 50% Human Human +DTXSID0046193 Css NA 0.237 mg/L PBTK NA 95% Human Human +DTXSID0046193 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046193 Fup 0.324 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046193 Vd NA 4.012 L/kg 1compartment NA NA Rat Human DTXSID0046193 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046193 TK.Half.Life NA 2.703 hours 1compartment NA NA Rat Human -DTXSID0046193 Css NA 0.01553 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046193 Css NA 0.145 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046193 Css NA 0.02804 mg/L PBTK NA 50% Rat Human -DTXSID0046193 Css NA 0.1512 mg/L PBTK NA 95% Rat Human -DTXSID0046195 Clint NA 1122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046195 Fup NA 0.2523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046195 Vd NA 0.7728 L/kg 1compartment NA NA Human Human +DTXSID0046193 TK.Half.Life NA 1.673 hours 1compartment NA NA Rat Human +DTXSID0046193 Css NA 0.002718 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046193 Css NA 0.02264 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046193 Css NA 0.00406 mg/L PBTK NA 50% Rat Human +DTXSID0046193 Css NA 0.02397 mg/L PBTK NA 95% Rat Human +DTXSID0046195 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046195 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046195 Vd NA 1.001 L/kg 1compartment NA NA Human Human DTXSID0046195 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046195 TK.Half.Life NA 0.6096 hours 1compartment NA NA Human Human -DTXSID0046195 Css NA 0.001726 mg/L 3compartmentss NA 50% Human Human -DTXSID0046195 Css NA 0.01377 mg/L 3compartmentss NA 95% Human Human -DTXSID0046195 Css NA 0.00123 mg/L PBTK NA 50% Human Human -DTXSID0046195 Css NA 0.009109 mg/L PBTK NA 95% Human Human -DTXSID0046195 Clint NA 1122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046195 Fup NA 0.2523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046195 Vd NA 0.6828 L/kg 1compartment NA NA Rat Human +DTXSID0046195 TK.Half.Life NA 2.068 hours 1compartment NA NA Human Human +DTXSID0046195 Css NA 0.16 mg/L 3compartmentss NA 50% Human Human +DTXSID0046195 Css NA 1.141 mg/L 3compartmentss NA 95% Human Human +DTXSID0046195 Css NA 0.1251 mg/L PBTK NA 50% Human Human +DTXSID0046195 Css NA 0.7883 mg/L PBTK NA 95% Human Human +DTXSID0046195 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046195 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046195 Vd NA 0.8877 L/kg 1compartment NA NA Rat Human DTXSID0046195 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046195 TK.Half.Life NA 0.2361 hours 1compartment NA NA Rat Human -DTXSID0046195 Css NA 0.0009583 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046195 Css NA 0.006064 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046195 Css NA 0.0006463 mg/L PBTK NA 50% Rat Human -DTXSID0046195 Css NA 0.003842 mg/L PBTK NA 95% Rat Human -DTXSID0046197 Clint NA 69.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046197 Fup NA 0.0454 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046197 Vd NA 2.347 L/kg 1compartment NA NA Human Human -DTXSID0046197 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046197 TK.Half.Life NA 6.4 hours 1compartment NA NA Human Human -DTXSID0046197 Css NA 0.276 mg/L 3compartmentss NA 50% Human Human -DTXSID0046197 Css NA 1.738 mg/L 3compartmentss NA 95% Human Human -DTXSID0046197 Css NA 0.1845 mg/L PBTK NA 50% Human Human -DTXSID0046197 Css NA 1.134 mg/L PBTK NA 95% Human Human -DTXSID0046197 Clint NA 69.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046197 Fup NA 0.0454 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046197 Vd NA 1.756 L/kg 1compartment NA NA Rat Human -DTXSID0046197 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046197 TK.Half.Life NA 1.853 hours 1compartment NA NA Rat Human -DTXSID0046197 Css NA 0.1541 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046197 Css NA 0.8274 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046197 Css NA 0.09761 mg/L PBTK NA 50% Rat Human -DTXSID0046197 Css NA 0.5035 mg/L PBTK NA 95% Rat Human -DTXSID0046199 Clint NA 0.1414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0046195 TK.Half.Life NA 0.9949 hours 1compartment NA NA Rat Human +DTXSID0046195 Css NA 0.01874 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046195 Css NA 0.09471 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046195 Css NA 0.01456 mg/L PBTK NA 50% Rat Human +DTXSID0046195 Css NA 0.06244 mg/L PBTK NA 95% Rat Human +DTXSID0046197 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046197 Fup 0.0298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046197 Vd NA 2.451 L/kg 1compartment NA NA Human Human +DTXSID0046197 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0046197 TK.Half.Life NA 23.45 hours 1compartment NA NA Human Human +DTXSID0046197 Css NA 1.298 mg/L 3compartmentss NA 50% Human Human +DTXSID0046197 Css NA 9.603 mg/L 3compartmentss NA 95% Human Human +DTXSID0046197 Css NA 0.8606 mg/L PBTK NA 50% Human Human +DTXSID0046197 Css NA 6.151 mg/L PBTK NA 95% Human Human +DTXSID0046197 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046197 Fup 0.0298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046197 Vd NA 1.831 L/kg 1compartment NA NA Rat Human +DTXSID0046197 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0046197 TK.Half.Life NA 6.033 hours 1compartment NA NA Rat Human +DTXSID0046197 Css NA 0.168 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046197 Css NA 1.017 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046197 Css NA 0.1091 mg/L PBTK NA 50% Rat Human +DTXSID0046197 Css NA 0.6357 mg/L PBTK NA 95% Rat Human +DTXSID0046199 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0046199 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0046199 Vd NA 0.5333 L/kg 1compartment NA NA Human Human +DTXSID0046199 Vd NA 0.5009 L/kg 1compartment NA NA Human Human DTXSID0046199 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046199 TK.Half.Life NA 2.894 hours 1compartment NA NA Human Human -DTXSID0046199 Css NA 0.7572 mg/L 3compartmentss NA 50% Human Human -DTXSID0046199 Css NA 3.912 mg/L 3compartmentss NA 95% Human Human -DTXSID0046199 Css NA 0.5766 mg/L PBTK NA 50% Human Human -DTXSID0046199 Css NA 2.488 mg/L PBTK NA 95% Human Human -DTXSID0046199 Clint NA 0.1414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0046199 TK.Half.Life NA 3.375 hours 1compartment NA NA Human Human +DTXSID0046199 Css NA 0.5386 mg/L 3compartmentss NA 50% Human Human +DTXSID0046199 Css NA 2.953 mg/L 3compartmentss NA 95% Human Human +DTXSID0046199 Css NA 0.4076 mg/L PBTK NA 50% Human Human +DTXSID0046199 Css NA 1.874 mg/L PBTK NA 95% Human Human +DTXSID0046199 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0046199 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0046199 Vd NA 0.5553 L/kg 1compartment NA NA Rat Human +DTXSID0046199 Vd NA 0.527 L/kg 1compartment NA NA Rat Human DTXSID0046199 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046199 TK.Half.Life NA 1.14 hours 1compartment NA NA Rat Human -DTXSID0046199 Css NA 0.219 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046199 Css NA 1.171 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046199 Css NA 0.1621 mg/L PBTK NA 50% Rat Human -DTXSID0046199 Css NA 0.6874 mg/L PBTK NA 95% Rat Human -DTXSID0046220 Clint NA 7.771 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046220 Fup NA 0.1035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046220 Vd NA 1.95 L/kg 1compartment NA NA Human Human -DTXSID0046220 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0046220 TK.Half.Life NA 13.92 hours 1compartment NA NA Human Human -DTXSID0046220 Css NA 0.952 mg/L 3compartmentss NA 50% Human Human -DTXSID0046220 Css NA 5.976 mg/L 3compartmentss NA 95% Human Human -DTXSID0046220 Css NA 0.6458 mg/L PBTK NA 50% Human Human -DTXSID0046220 Css NA 3.803 mg/L PBTK NA 95% Human Human -DTXSID0046220 Clint NA 7.771 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046220 Fup NA 0.1035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046220 Vd NA 1.479 L/kg 1compartment NA NA Rat Human +DTXSID0046199 TK.Half.Life NA 1.21 hours 1compartment NA NA Rat Human +DTXSID0046199 Css NA 0.002836 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046199 Css NA 0.01585 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046199 Css NA 0.002052 mg/L PBTK NA 50% Rat Human +DTXSID0046199 Css NA 0.009782 mg/L PBTK NA 95% Rat Human +DTXSID0046220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046220 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046220 Vd NA 2.037 L/kg 1compartment NA NA Human Human +DTXSID0046220 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0046220 TK.Half.Life NA 5.786 hours 1compartment NA NA Human Human +DTXSID0046220 Css NA 0.2845 mg/L 3compartmentss NA 50% Human Human +DTXSID0046220 Css NA 2.09 mg/L 3compartmentss NA 95% Human Human +DTXSID0046220 Css NA 0.1969 mg/L PBTK NA 50% Human Human +DTXSID0046220 Css NA 1.367 mg/L PBTK NA 95% Human Human +DTXSID0046220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046220 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046220 Vd NA 1.55 L/kg 1compartment NA NA Rat Human DTXSID0046220 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046220 TK.Half.Life NA 4.581 hours 1compartment NA NA Rat Human -DTXSID0046220 Css NA 0.5102 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046220 Css NA 2.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046220 Css NA 0.3272 mg/L PBTK NA 50% Rat Human -DTXSID0046220 Css NA 1.395 mg/L PBTK NA 95% Rat Human -DTXSID0046222 Clint NA 25.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046222 Fup NA 0.0732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046222 Vd NA 2.505 L/kg 1compartment NA NA Human Human +DTXSID0046220 TK.Half.Life NA 1.911 hours 1compartment NA NA Rat Human +DTXSID0046220 Css NA 0.03634 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046220 Css NA 0.2075 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046220 Css NA 0.02476 mg/L PBTK NA 50% Rat Human +DTXSID0046220 Css NA 0.1321 mg/L PBTK NA 95% Rat Human +DTXSID0046222 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046222 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046222 Vd NA 3.618 L/kg 1compartment NA NA Human Human DTXSID0046222 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046222 TK.Half.Life NA 6.762 hours 1compartment NA NA Human Human -DTXSID0046222 Css NA 0.2786 mg/L 3compartmentss NA 50% Human Human -DTXSID0046222 Css NA 2.103 mg/L 3compartmentss NA 95% Human Human -DTXSID0046222 Css NA 0.2066 mg/L PBTK NA 50% Human Human -DTXSID0046222 Css NA 1.441 mg/L PBTK NA 95% Human Human -DTXSID0046222 Clint NA 25.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046222 Fup NA 0.0732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046222 Vd NA 2.135 L/kg 1compartment NA NA Rat Human +DTXSID0046222 TK.Half.Life NA 9.047 hours 1compartment NA NA Human Human +DTXSID0046222 Css NA 0.185 mg/L 3compartmentss NA 50% Human Human +DTXSID0046222 Css NA 1.242 mg/L 3compartmentss NA 95% Human Human +DTXSID0046222 Css NA 0.1565 mg/L PBTK NA 50% Human Human +DTXSID0046222 Css NA 0.9604 mg/L PBTK NA 95% Human Human +DTXSID0046222 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046222 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046222 Vd NA 3.013 L/kg 1compartment NA NA Rat Human DTXSID0046222 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046222 TK.Half.Life NA 2.72 hours 1compartment NA NA Rat Human -DTXSID0046222 Css NA 0.1544 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046222 Css NA 0.9186 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046222 Css NA 0.1102 mg/L PBTK NA 50% Rat Human -DTXSID0046222 Css NA 0.5952 mg/L PBTK NA 95% Rat Human +DTXSID0046222 TK.Half.Life NA 2.291 hours 1compartment NA NA Rat Human +DTXSID0046222 Css NA 0.02314 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046222 Css NA 0.1217 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046222 Css NA 0.01988 mg/L PBTK NA 50% Rat Human +DTXSID0046222 Css NA 0.09921 mg/L PBTK NA 95% Rat Human DTXSID0046224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0046224 Fup NA 0.934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046224 Vd NA 0.6722 L/kg 1compartment NA NA Human Human +DTXSID0046224 Vd NA 0.7082 L/kg 1compartment NA NA Human Human DTXSID0046224 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046224 TK.Half.Life NA 4.655 hours 1compartment NA NA Human Human -DTXSID0046224 Css NA 0.9281 mg/L 3compartmentss NA 50% Human Human -DTXSID0046224 Css NA 5.126 mg/L 3compartmentss NA 95% Human Human -DTXSID0046224 Css NA 0.7512 mg/L PBTK NA 50% Human Human -DTXSID0046224 Css NA 3.342 mg/L PBTK NA 95% Human Human +DTXSID0046224 TK.Half.Life NA 4.906 hours 1compartment NA NA Human Human +DTXSID0046224 Css NA 0.7812 mg/L 3compartmentss NA 50% Human Human +DTXSID0046224 Css NA 4.315 mg/L 3compartmentss NA 95% Human Human +DTXSID0046224 Css NA 0.6374 mg/L PBTK NA 50% Human Human +DTXSID0046224 Css NA 2.8 mg/L PBTK NA 95% Human Human DTXSID0046224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0046224 Fup NA 0.934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046224 Vd NA 0.7249 L/kg 1compartment NA NA Rat Human +DTXSID0046224 Vd NA 0.7545 L/kg 1compartment NA NA Rat Human DTXSID0046224 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046224 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human -DTXSID0046224 Css NA 0.2372 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046224 Css NA 1.301 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046224 Css NA 0.1863 mg/L PBTK NA 50% Rat Human -DTXSID0046224 Css NA 0.7792 mg/L PBTK NA 95% Rat Human -DTXSID0046226 Clint NA 11.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046226 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046226 Vd NA 0.2361 L/kg 1compartment NA NA Human Human +DTXSID0046224 TK.Half.Life NA 1.781 hours 1compartment NA NA Rat Human +DTXSID0046224 Css NA 0.01468 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046224 Css NA 0.1033 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046224 Css NA 0.01154 mg/L PBTK NA 50% Rat Human +DTXSID0046224 Css NA 0.06716 mg/L PBTK NA 95% Rat Human +DTXSID0046226 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046226 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046226 Vd NA 0.3718 L/kg 1compartment NA NA Human Human DTXSID0046226 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046226 TK.Half.Life NA 3.081 hours 1compartment NA NA Human Human -DTXSID0046226 Css NA 2.284 mg/L 3compartmentss NA 50% Human Human -DTXSID0046226 Css NA 21.42 mg/L 3compartmentss NA 95% Human Human -DTXSID0046226 Css NA 1.352 mg/L PBTK NA 50% Human Human -DTXSID0046226 Css NA 12.66 mg/L PBTK NA 95% Human Human -DTXSID0046226 Clint NA 11.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046226 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046226 Vd NA 0.2295 L/kg 1compartment NA NA Rat Human +DTXSID0046226 TK.Half.Life NA 2.386 hours 1compartment NA NA Human Human +DTXSID0046226 Css NA 0.8972 mg/L 3compartmentss NA 50% Human Human +DTXSID0046226 Css NA 6.479 mg/L 3compartmentss NA 95% Human Human +DTXSID0046226 Css NA 0.5786 mg/L PBTK NA 50% Human Human +DTXSID0046226 Css NA 3.887 mg/L PBTK NA 95% Human Human +DTXSID0046226 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046226 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046226 Vd NA 0.3632 L/kg 1compartment NA NA Rat Human DTXSID0046226 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046226 TK.Half.Life NA 1.941 hours 1compartment NA NA Rat Human -DTXSID0046226 Css NA 1.262 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046226 Css NA 8.709 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046226 Css NA 0.7052 mg/L PBTK NA 50% Rat Human -DTXSID0046226 Css NA 4.735 mg/L PBTK NA 95% Rat Human -DTXSID0046228 Clint NA 0.2757 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046228 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046228 Vd NA 0.2117 L/kg 1compartment NA NA Human Human -DTXSID0046228 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID0046228 TK.Half.Life NA 91.94 hours 1compartment NA NA Human Human -DTXSID0046228 Css NA 73.47 mg/L 3compartmentss NA 50% Human Human -DTXSID0046228 Css NA 474.7 mg/L 3compartmentss NA 95% Human Human -DTXSID0046228 Css NA 43.32 mg/L PBTK NA 50% Human Human -DTXSID0046228 Css NA 271.4 mg/L PBTK NA 95% Human Human -DTXSID0046228 Clint NA 0.2757 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046228 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046228 Vd NA 0.2038 L/kg 1compartment NA NA Rat Human -DTXSID0046228 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID0046228 TK.Half.Life NA 35.99 hours 1compartment NA NA Rat Human -DTXSID0046228 Css NA 25.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046228 Css NA 148.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046228 Css NA 14.06 mg/L PBTK NA 50% Rat Human -DTXSID0046228 Css NA 80.29 mg/L PBTK NA 95% Rat Human -DTXSID0046270 Clint NA 34.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046270 Fup NA 0.2082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046270 Vd NA 3.748 L/kg 1compartment NA NA Human Human +DTXSID0046226 TK.Half.Life NA 1.425 hours 1compartment NA NA Rat Human +DTXSID0046226 Css NA 0.1098 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046226 Css NA 0.6034 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046226 Css NA 0.06887 mg/L PBTK NA 50% Rat Human +DTXSID0046226 Css NA 0.3546 mg/L PBTK NA 95% Rat Human +DTXSID0046228 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046228 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046228 Vd NA 1.655 L/kg 1compartment NA NA Human Human +DTXSID0046228 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0046228 TK.Half.Life NA 16.26 hours 1compartment NA NA Human Human +DTXSID0046228 Css NA 1.494 mg/L 3compartmentss NA 50% Human Human +DTXSID0046228 Css NA 13.35 mg/L 3compartmentss NA 95% Human Human +DTXSID0046228 Css NA 0.9412 mg/L PBTK NA 50% Human Human +DTXSID0046228 Css NA 8.081 mg/L PBTK NA 95% Human Human +DTXSID0046228 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046228 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046228 Vd NA 1.228 L/kg 1compartment NA NA Rat Human +DTXSID0046228 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0046228 TK.Half.Life NA 5.96 hours 1compartment NA NA Rat Human +DTXSID0046228 Css NA 0.1938 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046228 Css NA 1.411 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046228 Css NA 0.119 mg/L PBTK NA 50% Rat Human +DTXSID0046228 Css NA 0.8282 mg/L PBTK NA 95% Rat Human +DTXSID0046270 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046270 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046270 Vd NA 1.03 L/kg 1compartment NA NA Human Human DTXSID0046270 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046270 TK.Half.Life NA 4.229 hours 1compartment NA NA Human Human -DTXSID0046270 Css NA 0.05254 mg/L 3compartmentss NA 50% Human Human -DTXSID0046270 Css NA 0.3802 mg/L 3compartmentss NA 95% Human Human -DTXSID0046270 Css NA 0.05262 mg/L PBTK NA 50% Human Human -DTXSID0046270 Css NA 0.344 mg/L PBTK NA 95% Human Human -DTXSID0046270 Clint NA 34.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046270 Fup NA 0.2082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046270 Vd NA 3.448 L/kg 1compartment NA NA Rat Human +DTXSID0046270 TK.Half.Life NA 2.955 hours 1compartment NA NA Human Human +DTXSID0046270 Css NA 0.2498 mg/L 3compartmentss NA 50% Human Human +DTXSID0046270 Css NA 1.587 mg/L 3compartmentss NA 95% Human Human +DTXSID0046270 Css NA 0.1892 mg/L PBTK NA 50% Human Human +DTXSID0046270 Css NA 1.061 mg/L PBTK NA 95% Human Human +DTXSID0046270 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046270 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046270 Vd NA 1.032 L/kg 1compartment NA NA Rat Human DTXSID0046270 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046270 TK.Half.Life NA 1.732 hours 1compartment NA NA Rat Human -DTXSID0046270 Css NA 0.0282 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046270 Css NA 0.1607 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046270 Css NA 0.02796 mg/L PBTK NA 50% Rat Human -DTXSID0046270 Css NA 0.1409 mg/L PBTK NA 95% Rat Human -DTXSID0046272 Clint NA 13.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046272 Fup NA 0.0905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046272 Vd NA 0.8253 L/kg 1compartment NA NA Human Human +DTXSID0046270 TK.Half.Life NA 1.727 hours 1compartment NA NA Rat Human +DTXSID0046270 Css NA 0.0298 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046270 Css NA 0.1348 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046270 Css NA 0.02234 mg/L PBTK NA 50% Rat Human +DTXSID0046270 Css NA 0.08781 mg/L PBTK NA 95% Rat Human +DTXSID0046272 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046272 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046272 Vd NA 1.033 L/kg 1compartment NA NA Human Human DTXSID0046272 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046272 TK.Half.Life NA 3.151 hours 1compartment NA NA Human Human -DTXSID0046272 Css NA 0.505 mg/L 3compartmentss NA 50% Human Human -DTXSID0046272 Css NA 3.83 mg/L 3compartmentss NA 95% Human Human -DTXSID0046272 Css NA 0.3206 mg/L PBTK NA 50% Human Human -DTXSID0046272 Css NA 2.285 mg/L PBTK NA 95% Human Human -DTXSID0046272 Clint NA 13.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046272 Fup NA 0.0905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046272 Vd NA 0.6581 L/kg 1compartment NA NA Rat Human +DTXSID0046272 TK.Half.Life NA 5.357 hours 1compartment NA NA Human Human +DTXSID0046272 Css NA 0.6518 mg/L 3compartmentss NA 50% Human Human +DTXSID0046272 Css NA 4.584 mg/L 3compartmentss NA 95% Human Human +DTXSID0046272 Css NA 0.435 mg/L PBTK NA 50% Human Human +DTXSID0046272 Css NA 2.847 mg/L PBTK NA 95% Human Human +DTXSID0046272 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046272 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046272 Vd NA 0.8247 L/kg 1compartment NA NA Rat Human DTXSID0046272 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046272 TK.Half.Life NA 1.465 hours 1compartment NA NA Rat Human -DTXSID0046272 Css NA 0.2759 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046272 Css NA 1.618 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046272 Css NA 0.1658 mg/L PBTK NA 50% Rat Human -DTXSID0046272 Css NA 0.9217 mg/L PBTK NA 95% Rat Human -DTXSID0046274 Clint NA 41.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046274 Fup NA 0.2771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046274 Vd NA 2.528 L/kg 1compartment NA NA Human Human +DTXSID0046272 TK.Half.Life NA 2.379 hours 1compartment NA NA Rat Human +DTXSID0046272 Css NA 0.08048 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046272 Css NA 0.4114 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046272 Css NA 0.05218 mg/L PBTK NA 50% Rat Human +DTXSID0046272 Css NA 0.2451 mg/L PBTK NA 95% Rat Human +DTXSID0046274 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046274 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046274 Vd NA 1.776 L/kg 1compartment NA NA Human Human DTXSID0046274 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046274 TK.Half.Life NA 2.123 hours 1compartment NA NA Human Human -DTXSID0046274 Css NA 0.02798 mg/L 3compartmentss NA 50% Human Human -DTXSID0046274 Css NA 0.2337 mg/L 3compartmentss NA 95% Human Human -DTXSID0046274 Css NA 0.02751 mg/L PBTK NA 50% Human Human -DTXSID0046274 Css NA 0.197 mg/L PBTK NA 95% Human Human -DTXSID0046274 Clint NA 41.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046274 Fup NA 0.2771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046274 Vd NA 2.551 L/kg 1compartment NA NA Rat Human +DTXSID0046274 TK.Half.Life NA 3.836 hours 1compartment NA NA Human Human +DTXSID0046274 Css NA 0.155 mg/L 3compartmentss NA 50% Human Human +DTXSID0046274 Css NA 1.096 mg/L 3compartmentss NA 95% Human Human +DTXSID0046274 Css NA 0.138 mg/L PBTK NA 50% Human Human +DTXSID0046274 Css NA 0.832 mg/L PBTK NA 95% Human Human +DTXSID0046274 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046274 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046274 Vd NA 1.787 L/kg 1compartment NA NA Rat Human DTXSID0046274 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046274 TK.Half.Life NA 1.118 hours 1compartment NA NA Rat Human -DTXSID0046274 Css NA 0.01518 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046274 Css NA 0.1012 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046274 Css NA 0.01475 mg/L PBTK NA 50% Rat Human -DTXSID0046274 Css NA 0.07709 mg/L PBTK NA 95% Rat Human -DTXSID0046276 Clint NA 3.434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046276 Fup NA 0.0256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046276 Vd NA 0.4137 L/kg 1compartment NA NA Human Human -DTXSID0046276 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0046276 TK.Half.Life NA 15.22 hours 1compartment NA NA Human Human -DTXSID0046276 Css NA 6.638 mg/L 3compartmentss NA 50% Human Human -DTXSID0046276 Css NA 52.23 mg/L 3compartmentss NA 95% Human Human -DTXSID0046276 Css NA 3.958 mg/L PBTK NA 50% Human Human -DTXSID0046276 Css NA 30.23 mg/L PBTK NA 95% Human Human -DTXSID0046276 Clint NA 3.434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046276 Fup NA 0.0256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046276 Vd NA 0.3321 L/kg 1compartment NA NA Rat Human +DTXSID0046274 TK.Half.Life NA 2.229 hours 1compartment NA NA Rat Human +DTXSID0046274 Css NA 0.01801 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046274 Css NA 0.09677 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046274 Css NA 0.0162 mg/L PBTK NA 50% Rat Human +DTXSID0046274 Css NA 0.06962 mg/L PBTK NA 95% Rat Human +DTXSID0046276 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046276 Fup 0.0642 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046276 Vd NA 0.7428 L/kg 1compartment NA NA Human Human +DTXSID0046276 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0046276 TK.Half.Life NA 2.638 hours 1compartment NA NA Human Human +DTXSID0046276 Css NA 0.4523 mg/L 3compartmentss NA 50% Human Human +DTXSID0046276 Css NA 3.48 mg/L 3compartmentss NA 95% Human Human +DTXSID0046276 Css NA 0.2828 mg/L PBTK NA 50% Human Human +DTXSID0046276 Css NA 2.094 mg/L PBTK NA 95% Human Human +DTXSID0046276 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046276 Fup 0.0642 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046276 Vd NA 0.5784 L/kg 1compartment NA NA Rat Human DTXSID0046276 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046276 TK.Half.Life NA 7.28 hours 1compartment NA NA Rat Human -DTXSID0046276 Css NA 3.358 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046276 Css NA 20.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046276 Css NA 1.865 mg/L PBTK NA 50% Rat Human -DTXSID0046276 Css NA 11.24 mg/L PBTK NA 95% Rat Human -DTXSID0046305 Clint NA 50.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046305 Fup NA 0.0088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046305 Vd NA 2.358 L/kg 1compartment NA NA Human Human +DTXSID0046276 TK.Half.Life NA 1.208 hours 1compartment NA NA Rat Human +DTXSID0046276 Css NA 0.05965 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046276 Css NA 0.3585 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046276 Css NA 0.0359 mg/L PBTK NA 50% Rat Human +DTXSID0046276 Css NA 0.21 mg/L PBTK NA 95% Rat Human +DTXSID0046305 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046305 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046305 Vd NA 1.425 L/kg 1compartment NA NA Human Human DTXSID0046305 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046305 TK.Half.Life NA 6.412 hours 1compartment NA NA Human Human -DTXSID0046305 Css NA 0.293 mg/L 3compartmentss NA 50% Human Human -DTXSID0046305 Css NA 2.544 mg/L 3compartmentss NA 95% Human Human -DTXSID0046305 Css NA 0.1956 mg/L PBTK NA 50% Human Human -DTXSID0046305 Css NA 1.578 mg/L PBTK NA 95% Human Human -DTXSID0046305 Clint NA 50.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046305 Fup NA 0.0088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046305 Vd NA 1.83 L/kg 1compartment NA NA Rat Human +DTXSID0046305 TK.Half.Life NA 3.024 hours 1compartment NA NA Human Human +DTXSID0046305 Css NA 0.1938 mg/L 3compartmentss NA 50% Human Human +DTXSID0046305 Css NA 1.707 mg/L 3compartmentss NA 95% Human Human +DTXSID0046305 Css NA 0.1417 mg/L PBTK NA 50% Human Human +DTXSID0046305 Css NA 1.141 mg/L PBTK NA 95% Human Human +DTXSID0046305 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046305 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046305 Vd NA 1.409 L/kg 1compartment NA NA Rat Human DTXSID0046305 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046305 TK.Half.Life NA 2.079 hours 1compartment NA NA Rat Human -DTXSID0046305 Css NA 0.1665 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046305 Css NA 1.262 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046305 Css NA 0.1054 mg/L PBTK NA 50% Rat Human -DTXSID0046305 Css NA 0.7423 mg/L PBTK NA 95% Rat Human -DTXSID0046307 Clint NA 7.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046307 Fup NA 0.0933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046307 Vd NA 1.286 L/kg 1compartment NA NA Human Human +DTXSID0046305 TK.Half.Life NA 1.766 hours 1compartment NA NA Rat Human +DTXSID0046305 Css NA 0.0249 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046305 Css NA 0.1723 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046305 Css NA 0.01799 mg/L PBTK NA 50% Rat Human +DTXSID0046305 Css NA 0.1116 mg/L PBTK NA 95% Rat Human +DTXSID0046307 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046307 Fup 0.302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046307 Vd NA 1.495 L/kg 1compartment NA NA Human Human DTXSID0046307 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046307 TK.Half.Life NA 7.612 hours 1compartment NA NA Human Human -DTXSID0046307 Css NA 0.8241 mg/L 3compartmentss NA 50% Human Human -DTXSID0046307 Css NA 5.612 mg/L 3compartmentss NA 95% Human Human -DTXSID0046307 Css NA 0.5461 mg/L PBTK NA 50% Human Human -DTXSID0046307 Css NA 3.567 mg/L PBTK NA 95% Human Human -DTXSID0046307 Clint NA 7.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046307 Fup NA 0.0933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046307 Vd NA 1.062 L/kg 1compartment NA NA Rat Human +DTXSID0046307 TK.Half.Life NA 3.866 hours 1compartment NA NA Human Human +DTXSID0046307 Css NA 0.2138 mg/L 3compartmentss NA 50% Human Human +DTXSID0046307 Css NA 1.353 mg/L 3compartmentss NA 95% Human Human +DTXSID0046307 Css NA 0.17 mg/L PBTK NA 50% Human Human +DTXSID0046307 Css NA 0.9713 mg/L PBTK NA 95% Human Human +DTXSID0046307 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046307 Fup 0.302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046307 Vd NA 1.353 L/kg 1compartment NA NA Rat Human DTXSID0046307 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046307 TK.Half.Life NA 3.511 hours 1compartment NA NA Rat Human -DTXSID0046307 Css NA 0.4368 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046307 Css NA 2.224 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046307 Css NA 0.2746 mg/L PBTK NA 50% Rat Human -DTXSID0046307 Css NA 1.302 mg/L PBTK NA 95% Rat Human -DTXSID0046309 Clint NA 94.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046309 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046309 Vd NA 2.593 L/kg 1compartment NA NA Human Human -DTXSID0046309 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046309 TK.Half.Life NA 11.53 hours 1compartment NA NA Human Human -DTXSID0046309 Css NA 0.5439 mg/L 3compartmentss NA 50% Human Human -DTXSID0046309 Css NA 4.06 mg/L 3compartmentss NA 95% Human Human -DTXSID0046309 Css NA 0.3614 mg/L PBTK NA 50% Human Human -DTXSID0046309 Css NA 2.568 mg/L PBTK NA 95% Human Human -DTXSID0046309 Clint NA 94.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046309 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046309 Vd NA 1.936 L/kg 1compartment NA NA Rat Human -DTXSID0046309 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046309 TK.Half.Life NA 2.845 hours 1compartment NA NA Rat Human -DTXSID0046309 Css NA 0.304 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046309 Css NA 1.948 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046309 Css NA 0.1925 mg/L PBTK NA 50% Rat Human -DTXSID0046309 Css NA 1.171 mg/L PBTK NA 95% Rat Human -DTXSID0046351 Clint NA 2.249 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046351 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046351 Vd NA 1.516 L/kg 1compartment NA NA Human Human +DTXSID0046307 TK.Half.Life NA 1.902 hours 1compartment NA NA Rat Human +DTXSID0046307 Css NA 0.02477 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046307 Css NA 0.1211 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046307 Css NA 0.0199 mg/L PBTK NA 50% Rat Human +DTXSID0046307 Css NA 0.08092 mg/L PBTK NA 95% Rat Human +DTXSID0046309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046309 Fup 0.0197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046309 Vd NA 2.746 L/kg 1compartment NA NA Human Human +DTXSID0046309 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID0046309 TK.Half.Life NA 40.49 hours 1compartment NA NA Human Human +DTXSID0046309 Css NA 1.958 mg/L 3compartmentss NA 50% Human Human +DTXSID0046309 Css NA 13.87 mg/L 3compartmentss NA 95% Human Human +DTXSID0046309 Css NA 1.319 mg/L PBTK NA 50% Human Human +DTXSID0046309 Css NA 8.991 mg/L PBTK NA 95% Human Human +DTXSID0046309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046309 Fup 0.0197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046309 Vd NA 2.055 L/kg 1compartment NA NA Rat Human +DTXSID0046309 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0046309 TK.Half.Life NA 8.394 hours 1compartment NA NA Rat Human +DTXSID0046309 Css NA 0.2528 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046309 Css NA 1.496 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046309 Css NA 0.1672 mg/L PBTK NA 50% Rat Human +DTXSID0046309 Css NA 0.9539 mg/L PBTK NA 95% Rat Human +DTXSID0046351 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046351 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046351 Vd NA 1.004 L/kg 1compartment NA NA Human Human DTXSID0046351 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046351 TK.Half.Life NA 2.738 hours 1compartment NA NA Human Human -DTXSID0046351 Css NA 0.1608 mg/L 3compartmentss NA 50% Human Human -DTXSID0046351 Css NA 1.278 mg/L 3compartmentss NA 95% Human Human -DTXSID0046351 Css NA 0.1526 mg/L PBTK NA 50% Human Human -DTXSID0046351 Css NA 0.9613 mg/L PBTK NA 95% Human Human -DTXSID0046351 Clint NA 2.249 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046351 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046351 Vd NA 1.397 L/kg 1compartment NA NA Rat Human +DTXSID0046351 TK.Half.Life NA 1.741 hours 1compartment NA NA Human Human +DTXSID0046351 Css NA 0.1259 mg/L 3compartmentss NA 50% Human Human +DTXSID0046351 Css NA 0.9631 mg/L 3compartmentss NA 95% Human Human +DTXSID0046351 Css NA 0.1022 mg/L PBTK NA 50% Human Human +DTXSID0046351 Css NA 0.6652 mg/L PBTK NA 95% Human Human +DTXSID0046351 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046351 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046351 Vd NA 0.9187 L/kg 1compartment NA NA Rat Human DTXSID0046351 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046351 TK.Half.Life NA 1.238 hours 1compartment NA NA Rat Human -DTXSID0046351 Css NA 0.06782 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046351 Css NA 0.4763 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046351 Css NA 0.06464 mg/L PBTK NA 50% Rat Human -DTXSID0046351 Css NA 0.309 mg/L PBTK NA 95% Rat Human -DTXSID0046353 Clint NA 13.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046353 Fup NA 0.2284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046353 Vd NA 0.4135 L/kg 1compartment NA NA Human Human +DTXSID0046351 TK.Half.Life NA 0.8573 hours 1compartment NA NA Rat Human +DTXSID0046351 Css NA 0.01461 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046351 Css NA 0.08995 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046351 Css NA 0.01189 mg/L PBTK NA 50% Rat Human +DTXSID0046351 Css NA 0.05901 mg/L PBTK NA 95% Rat Human +DTXSID0046353 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046353 Fup 0.487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046353 Vd NA 0.6607 L/kg 1compartment NA NA Human Human DTXSID0046353 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046353 TK.Half.Life NA 0.832 hours 1compartment NA NA Human Human -DTXSID0046353 Css NA 0.1642 mg/L 3compartmentss NA 50% Human Human -DTXSID0046353 Css NA 1.105 mg/L 3compartmentss NA 95% Human Human -DTXSID0046353 Css NA 0.1089 mg/L PBTK NA 50% Human Human -DTXSID0046353 Css NA 0.7007 mg/L PBTK NA 95% Human Human -DTXSID0046353 Clint NA 13.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046353 Fup NA 0.2284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046353 Vd NA 0.4078 L/kg 1compartment NA NA Rat Human +DTXSID0046353 TK.Half.Life NA 1.162 hours 1compartment NA NA Human Human +DTXSID0046353 Css NA 0.06682 mg/L 3compartmentss NA 50% Human Human +DTXSID0046353 Css NA 0.5888 mg/L 3compartmentss NA 95% Human Human +DTXSID0046353 Css NA 0.05064 mg/L PBTK NA 50% Human Human +DTXSID0046353 Css NA 0.387 mg/L PBTK NA 95% Human Human +DTXSID0046353 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046353 Fup 0.487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046353 Vd NA 0.6461 L/kg 1compartment NA NA Rat Human DTXSID0046353 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046353 TK.Half.Life NA 0.4649 hours 1compartment NA NA Rat Human -DTXSID0046353 Css NA 0.08762 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046353 Css NA 0.4329 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046353 Css NA 0.05512 mg/L PBTK NA 50% Rat Human -DTXSID0046353 Css NA 0.2564 mg/L PBTK NA 95% Rat Human -DTXSID0046357 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046357 Fup NA 0.3754 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046357 Vd NA 3.246 L/kg 1compartment NA NA Human Human -DTXSID0046357 Days.Css NA 2830 Days PBTK NA NA Human Human -DTXSID0046357 TK.Half.Life NA 10320 hours 1compartment NA NA Human Human -DTXSID0046357 Css NA 348.2 mg/L 3compartmentss NA 50% Human Human -DTXSID0046357 Css NA 989.3 mg/L 3compartmentss NA 95% Human Human -DTXSID0046357 Css NA 251.3 mg/L PBTK NA 50% Human Human -DTXSID0046357 Css NA 655.6 mg/L PBTK NA 95% Human Human -DTXSID0046357 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046357 Fup NA 0.3754 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046357 Vd NA 2.474 L/kg 1compartment NA NA Rat Human -DTXSID0046357 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID0046357 TK.Half.Life NA 650.2 hours 1compartment NA NA Rat Human -DTXSID0046357 Css NA 94.04 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046357 Css NA 208.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046357 Css NA 64.91 mg/L PBTK NA 50% Rat Human -DTXSID0046357 Css NA 128.6 mg/L PBTK NA 95% Rat Human -DTXSID0046430 Clint NA 0.8307 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046430 Fup NA 0.4761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046430 Vd NA 0.4771 L/kg 1compartment NA NA Human Human +DTXSID0046353 TK.Half.Life NA 0.6217 hours 1compartment NA NA Rat Human +DTXSID0046353 Css NA 0.0005964 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046353 Css NA 0.004883 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046353 Css NA 0.0004412 mg/L PBTK NA 50% Rat Human +DTXSID0046353 Css NA 0.003048 mg/L PBTK NA 95% Rat Human +DTXSID0046357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046357 Fup 0.0298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046357 Vd NA 2.806 L/kg 1compartment NA NA Human Human +DTXSID0046357 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0046357 TK.Half.Life NA 14.64 hours 1compartment NA NA Human Human +DTXSID0046357 Css NA 0.617 mg/L 3compartmentss NA 50% Human Human +DTXSID0046357 Css NA 4.718 mg/L 3compartmentss NA 95% Human Human +DTXSID0046357 Css NA 0.4316 mg/L PBTK NA 50% Human Human +DTXSID0046357 Css NA 3.149 mg/L PBTK NA 95% Human Human +DTXSID0046357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046357 Fup 0.0298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046357 Vd NA 2.199 L/kg 1compartment NA NA Rat Human +DTXSID0046357 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0046357 TK.Half.Life NA 3.907 hours 1compartment NA NA Rat Human +DTXSID0046357 Css NA 0.0799 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046357 Css NA 0.5094 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046357 Css NA 0.05526 mg/L PBTK NA 50% Rat Human +DTXSID0046357 Css NA 0.3336 mg/L PBTK NA 95% Rat Human +DTXSID0046430 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046430 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046430 Vd NA 0.4219 L/kg 1compartment NA NA Human Human DTXSID0046430 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046430 TK.Half.Life NA 2.814 hours 1compartment NA NA Human Human -DTXSID0046430 Css NA 0.6447 mg/L 3compartmentss NA 50% Human Human -DTXSID0046430 Css NA 3.478 mg/L 3compartmentss NA 95% Human Human -DTXSID0046430 Css NA 0.4807 mg/L PBTK NA 50% Human Human -DTXSID0046430 Css NA 2.196 mg/L PBTK NA 95% Human Human -DTXSID0046430 Clint NA 0.8307 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046430 Fup NA 0.4761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046430 Vd NA 0.4853 L/kg 1compartment NA NA Rat Human +DTXSID0046430 TK.Half.Life NA 5.501 hours 1compartment NA NA Human Human +DTXSID0046430 Css NA 0.8245 mg/L 3compartmentss NA 50% Human Human +DTXSID0046430 Css NA 4.306 mg/L 3compartmentss NA 95% Human Human +DTXSID0046430 Css NA 0.6 mg/L PBTK NA 50% Human Human +DTXSID0046430 Css NA 2.702 mg/L PBTK NA 95% Human Human +DTXSID0046430 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046430 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046430 Vd NA 0.4365 L/kg 1compartment NA NA Rat Human DTXSID0046430 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046430 TK.Half.Life NA 1.362 hours 1compartment NA NA Rat Human -DTXSID0046430 Css NA 0.2494 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046430 Css NA 1.166 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046430 Css NA 0.1768 mg/L PBTK NA 50% Rat Human -DTXSID0046430 Css NA 0.6855 mg/L PBTK NA 95% Rat Human -DTXSID0046432 Clint NA 7.066 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046432 Fup NA 0.3629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046432 Vd NA 0.5998 L/kg 1compartment NA NA Human Human +DTXSID0046430 TK.Half.Life NA 1.941 hours 1compartment NA NA Rat Human +DTXSID0046430 Css NA 0.004378 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046430 Css NA 0.02434 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046430 Css NA 0.003042 mg/L PBTK NA 50% Rat Human +DTXSID0046430 Css NA 0.01447 mg/L PBTK NA 95% Rat Human +DTXSID0046432 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046432 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046432 Vd NA 0.6745 L/kg 1compartment NA NA Human Human DTXSID0046432 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046432 TK.Half.Life NA 1.226 hours 1compartment NA NA Human Human -DTXSID0046432 Css NA 0.1692 mg/L 3compartmentss NA 50% Human Human -DTXSID0046432 Css NA 1.087 mg/L 3compartmentss NA 95% Human Human -DTXSID0046432 Css NA 0.1234 mg/L PBTK NA 50% Human Human -DTXSID0046432 Css NA 0.729 mg/L PBTK NA 95% Human Human -DTXSID0046432 Clint NA 7.066 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046432 Fup NA 0.3629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046432 Vd NA 0.5819 L/kg 1compartment NA NA Rat Human +DTXSID0046432 TK.Half.Life NA 1.183 hours 1compartment NA NA Human Human +DTXSID0046432 Css NA 0.1302 mg/L 3compartmentss NA 50% Human Human +DTXSID0046432 Css NA 0.9501 mg/L 3compartmentss NA 95% Human Human +DTXSID0046432 Css NA 0.1031 mg/L PBTK NA 50% Human Human +DTXSID0046432 Css NA 0.657 mg/L PBTK NA 95% Human Human +DTXSID0046432 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046432 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046432 Vd NA 0.6844 L/kg 1compartment NA NA Rat Human DTXSID0046432 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046432 TK.Half.Life NA 0.6646 hours 1compartment NA NA Rat Human -DTXSID0046432 Css NA 0.08602 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046432 Css NA 0.4379 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046432 Css NA 0.05944 mg/L PBTK NA 50% Rat Human -DTXSID0046432 Css NA 0.2704 mg/L PBTK NA 95% Rat Human -DTXSID0046434 Clint NA 197.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046434 Fup NA 0.4841 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046434 Vd NA 2.276 L/kg 1compartment NA NA Human Human +DTXSID0046432 TK.Half.Life NA 0.6652 hours 1compartment NA NA Rat Human +DTXSID0046432 Css NA 0.01484 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046432 Css NA 0.08605 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046432 Css NA 0.01187 mg/L PBTK NA 50% Rat Human +DTXSID0046432 Css NA 0.05659 mg/L PBTK NA 95% Rat Human +DTXSID0046434 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046434 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046434 Vd NA 1.511 L/kg 1compartment NA NA Human Human DTXSID0046434 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046434 TK.Half.Life NA 1.662 hours 1compartment NA NA Human Human -DTXSID0046434 Css NA 0.007808 mg/L 3compartmentss NA 50% Human Human -DTXSID0046434 Css NA 0.06036 mg/L 3compartmentss NA 95% Human Human -DTXSID0046434 Css NA 0.006386 mg/L PBTK NA 50% Human Human -DTXSID0046434 Css NA 0.04468 mg/L PBTK NA 95% Human Human -DTXSID0046434 Clint NA 197.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046434 Fup NA 0.4841 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046434 Vd NA 1.806 L/kg 1compartment NA NA Rat Human +DTXSID0046434 TK.Half.Life NA 4.857 hours 1compartment NA NA Human Human +DTXSID0046434 Css NA 0.2946 mg/L 3compartmentss NA 50% Human Human +DTXSID0046434 Css NA 1.722 mg/L 3compartmentss NA 95% Human Human +DTXSID0046434 Css NA 0.2178 mg/L PBTK NA 50% Human Human +DTXSID0046434 Css NA 1.194 mg/L PBTK NA 95% Human Human +DTXSID0046434 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046434 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046434 Vd NA 1.213 L/kg 1compartment NA NA Rat Human DTXSID0046434 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046434 TK.Half.Life NA 0.5622 hours 1compartment NA NA Rat Human -DTXSID0046434 Css NA 0.00428 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046434 Css NA 0.02833 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046434 Css NA 0.00341 mg/L PBTK NA 50% Rat Human -DTXSID0046434 Css NA 0.02027 mg/L PBTK NA 95% Rat Human -DTXSID0046438 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046438 Fup NA 0.0775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046438 Vd NA 0.2876 L/kg 1compartment NA NA Human Human -DTXSID0046438 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0046438 TK.Half.Life NA 24.08 hours 1compartment NA NA Human Human -DTXSID0046438 Css NA 13.63 mg/L 3compartmentss NA 50% Human Human -DTXSID0046438 Css NA 59.93 mg/L 3compartmentss NA 95% Human Human -DTXSID0046438 Css NA 8.288 mg/L PBTK NA 50% Human Human -DTXSID0046438 Css NA 35.12 mg/L PBTK NA 95% Human Human -DTXSID0046438 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046438 Fup NA 0.0775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046438 Vd NA 0.2702 L/kg 1compartment NA NA Rat Human +DTXSID0046434 TK.Half.Life NA 1.95 hours 1compartment NA NA Rat Human +DTXSID0046434 Css NA 0.03469 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046434 Css NA 0.1511 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046434 Css NA 0.02578 mg/L PBTK NA 50% Rat Human +DTXSID0046434 Css NA 0.09956 mg/L PBTK NA 95% Rat Human +DTXSID0046438 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046438 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046438 Vd NA 0.6673 L/kg 1compartment NA NA Human Human +DTXSID0046438 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0046438 TK.Half.Life NA 1.52 hours 1compartment NA NA Human Human +DTXSID0046438 Css NA 0.1957 mg/L 3compartmentss NA 50% Human Human +DTXSID0046438 Css NA 1.593 mg/L 3compartmentss NA 95% Human Human +DTXSID0046438 Css NA 0.1281 mg/L PBTK NA 50% Human Human +DTXSID0046438 Css NA 0.9719 mg/L PBTK NA 95% Human Human +DTXSID0046438 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046438 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046438 Vd NA 0.5533 L/kg 1compartment NA NA Rat Human DTXSID0046438 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046438 TK.Half.Life NA 7.691 hours 1compartment NA NA Rat Human -DTXSID0046438 Css NA 3.814 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046438 Css NA 14.42 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046438 Css NA 2.169 mg/L PBTK NA 50% Rat Human -DTXSID0046438 Css NA 7.903 mg/L PBTK NA 95% Rat Human -DTXSID0046480 Clint NA 9.956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046480 Fup NA 0.0778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046480 Vd NA 0.2244 L/kg 1compartment NA NA Human Human +DTXSID0046438 TK.Half.Life NA 0.7199 hours 1compartment NA NA Rat Human +DTXSID0046438 Css NA 0.00961 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046438 Css NA 0.08718 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046438 Css NA 0.006096 mg/L PBTK NA 50% Rat Human +DTXSID0046438 Css NA 0.05233 mg/L PBTK NA 95% Rat Human +DTXSID0046480 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046480 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046480 Vd NA 0.3863 L/kg 1compartment NA NA Human Human DTXSID0046480 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046480 TK.Half.Life NA 1.255 hours 1compartment NA NA Human Human -DTXSID0046480 Css NA 0.859 mg/L 3compartmentss NA 50% Human Human -DTXSID0046480 Css NA 6.116 mg/L 3compartmentss NA 95% Human Human -DTXSID0046480 Css NA 0.5135 mg/L PBTK NA 50% Human Human -DTXSID0046480 Css NA 3.578 mg/L PBTK NA 95% Human Human -DTXSID0046480 Clint NA 9.956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046480 Fup NA 0.0778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046480 Vd NA 0.2227 L/kg 1compartment NA NA Rat Human +DTXSID0046480 TK.Half.Life NA 0.9189 hours 1compartment NA NA Human Human +DTXSID0046480 Css NA 0.183 mg/L 3compartmentss NA 50% Human Human +DTXSID0046480 Css NA 1.182 mg/L 3compartmentss NA 95% Human Human +DTXSID0046480 Css NA 0.1244 mg/L PBTK NA 50% Human Human +DTXSID0046480 Css NA 0.7527 mg/L PBTK NA 95% Human Human +DTXSID0046480 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046480 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046480 Vd NA 0.3872 L/kg 1compartment NA NA Rat Human DTXSID0046480 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046480 TK.Half.Life NA 0.7738 hours 1compartment NA NA Rat Human -DTXSID0046480 Css NA 0.467 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046480 Css NA 2.483 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046480 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID0046480 Css NA 1.366 mg/L PBTK NA 95% Rat Human -DTXSID0046482 Clint NA 8.566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0046480 TK.Half.Life NA 0.52 hours 1compartment NA NA Rat Human +DTXSID0046480 Css NA 0.008033 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046480 Css NA 0.05781 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046480 Css NA 0.005413 mg/L PBTK NA 50% Rat Human +DTXSID0046480 Css NA 0.036 mg/L PBTK NA 95% Rat Human +DTXSID0046482 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0046482 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0046482 Vd NA 0.246 L/kg 1compartment NA NA Human Human -DTXSID0046482 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046482 TK.Half.Life NA 2.276 hours 1compartment NA NA Human Human -DTXSID0046482 Css NA 1.555 mg/L 3compartmentss NA 50% Human Human -DTXSID0046482 Css NA 11.41 mg/L 3compartmentss NA 95% Human Human -DTXSID0046482 Css NA 0.9322 mg/L PBTK NA 50% Human Human -DTXSID0046482 Css NA 6.744 mg/L PBTK NA 95% Human Human -DTXSID0046482 Clint NA 8.566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0046482 Vd NA 0.2073 L/kg 1compartment NA NA Human Human +DTXSID0046482 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID0046482 TK.Half.Life NA 26.82 hours 1compartment NA NA Human Human +DTXSID0046482 Css NA 11.61 mg/L 3compartmentss NA 50% Human Human +DTXSID0046482 Css NA 59.65 mg/L 3compartmentss NA 95% Human Human +DTXSID0046482 Css NA 6.897 mg/L PBTK NA 50% Human Human +DTXSID0046482 Css NA 34.78 mg/L PBTK NA 95% Human Human +DTXSID0046482 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0046482 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0046482 Vd NA 0.2443 L/kg 1compartment NA NA Rat Human +DTXSID0046482 Vd NA 0.2104 L/kg 1compartment NA NA Rat Human DTXSID0046482 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046482 TK.Half.Life NA 1.43 hours 1compartment NA NA Rat Human -DTXSID0046482 Css NA 0.8386 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046482 Css NA 4.857 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046482 Css NA 0.4715 mg/L PBTK NA 50% Rat Human -DTXSID0046482 Css NA 2.661 mg/L PBTK NA 95% Rat Human -DTXSID0046484 Clint NA 52.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046484 Fup NA 0.934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046484 Vd NA 4.442 L/kg 1compartment NA NA Human Human +DTXSID0046482 TK.Half.Life NA 9.278 hours 1compartment NA NA Rat Human +DTXSID0046482 Css NA 0.06427 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046482 Css NA 0.3309 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046482 Css NA 0.03585 mg/L PBTK NA 50% Rat Human +DTXSID0046482 Css NA 0.1806 mg/L PBTK NA 95% Rat Human +DTXSID0046484 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046484 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046484 Vd NA 1.111 L/kg 1compartment NA NA Human Human DTXSID0046484 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046484 TK.Half.Life NA 4.25 hours 1compartment NA NA Human Human -DTXSID0046484 Css NA 0.03818 mg/L 3compartmentss NA 50% Human Human -DTXSID0046484 Css NA 0.2881 mg/L 3compartmentss NA 95% Human Human -DTXSID0046484 Css NA 0.03814 mg/L PBTK NA 50% Human Human -DTXSID0046484 Css NA 0.2499 mg/L PBTK NA 95% Human Human -DTXSID0046484 Clint NA 52.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046484 Fup NA 0.934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046484 Vd NA 3.867 L/kg 1compartment NA NA Rat Human +DTXSID0046484 TK.Half.Life NA 2.595 hours 1compartment NA NA Human Human +DTXSID0046484 Css NA 0.2319 mg/L 3compartmentss NA 50% Human Human +DTXSID0046484 Css NA 1.922 mg/L 3compartmentss NA 95% Human Human +DTXSID0046484 Css NA 0.161 mg/L PBTK NA 50% Human Human +DTXSID0046484 Css NA 1.217 mg/L PBTK NA 95% Human Human +DTXSID0046484 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046484 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046484 Vd NA 1.087 L/kg 1compartment NA NA Rat Human DTXSID0046484 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046484 TK.Half.Life NA 1.237 hours 1compartment NA NA Rat Human -DTXSID0046484 Css NA 0.0204 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046484 Css NA 0.1259 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046484 Css NA 0.02026 mg/L PBTK NA 50% Rat Human -DTXSID0046484 Css NA 0.1115 mg/L PBTK NA 95% Rat Human -DTXSID0046486 Clint NA 18.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046486 Fup NA 0.0984 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046486 Vd NA 2.728 L/kg 1compartment NA NA Human Human +DTXSID0046484 TK.Half.Life NA 1.504 hours 1compartment NA NA Rat Human +DTXSID0046484 Css NA 0.03018 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046484 Css NA 0.2008 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046484 Css NA 0.02045 mg/L PBTK NA 50% Rat Human +DTXSID0046484 Css NA 0.1251 mg/L PBTK NA 95% Rat Human +DTXSID0046486 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046486 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046486 Vd NA 1.537 L/kg 1compartment NA NA Human Human DTXSID0046486 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046486 TK.Half.Life NA 8.301 hours 1compartment NA NA Human Human -DTXSID0046486 Css NA 0.3112 mg/L 3compartmentss NA 50% Human Human -DTXSID0046486 Css NA 2.283 mg/L 3compartmentss NA 95% Human Human -DTXSID0046486 Css NA 0.2386 mg/L PBTK NA 50% Human Human -DTXSID0046486 Css NA 1.587 mg/L PBTK NA 95% Human Human -DTXSID0046486 Clint NA 18.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046486 Fup NA 0.0984 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046486 Vd NA 2.312 L/kg 1compartment NA NA Rat Human +DTXSID0046486 TK.Half.Life NA 8.436 hours 1compartment NA NA Human Human +DTXSID0046486 Css NA 0.6618 mg/L 3compartmentss NA 50% Human Human +DTXSID0046486 Css NA 4.216 mg/L 3compartmentss NA 95% Human Human +DTXSID0046486 Css NA 0.449 mg/L PBTK NA 50% Human Human +DTXSID0046486 Css NA 2.715 mg/L PBTK NA 95% Human Human +DTXSID0046486 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046486 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046486 Vd NA 1.186 L/kg 1compartment NA NA Rat Human DTXSID0046486 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046486 TK.Half.Life NA 3.096 hours 1compartment NA NA Rat Human -DTXSID0046486 Css NA 0.172 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046486 Css NA 0.951 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046486 Css NA 0.1267 mg/L PBTK NA 50% Rat Human -DTXSID0046486 Css NA 0.6512 mg/L PBTK NA 95% Rat Human -DTXSID0046488 Clint NA 28.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046488 Fup NA 0.0217 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046488 Vd NA 2.024 L/kg 1compartment NA NA Human Human -DTXSID0046488 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0046488 TK.Half.Life NA 15.53 hours 1compartment NA NA Human Human -DTXSID0046488 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID0046488 Css NA 9.168 mg/L 3compartmentss NA 95% Human Human -DTXSID0046488 Css NA 0.7353 mg/L PBTK NA 50% Human Human -DTXSID0046488 Css NA 5.726 mg/L PBTK NA 95% Human Human -DTXSID0046488 Clint NA 28.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046488 Fup NA 0.0217 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046488 Vd NA 1.507 L/kg 1compartment NA NA Rat Human -DTXSID0046488 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046488 TK.Half.Life NA 4.98 hours 1compartment NA NA Rat Human -DTXSID0046488 Css NA 0.6234 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046488 Css NA 4.241 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046488 Css NA 0.3804 mg/L PBTK NA 50% Rat Human -DTXSID0046488 Css NA 2.494 mg/L PBTK NA 95% Rat Human -DTXSID0046513 Clint NA 698.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046513 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046513 Vd NA 19.4 L/kg 1compartment NA NA Human Human -DTXSID0046513 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0046513 TK.Half.Life NA 22.94 hours 1compartment NA NA Human Human -DTXSID0046513 Css NA 0.03755 mg/L 3compartmentss NA 50% Human Human -DTXSID0046513 Css NA 0.2164 mg/L 3compartmentss NA 95% Human Human -DTXSID0046513 Css NA 0.07685 mg/L PBTK NA 50% Human Human -DTXSID0046513 Css NA 0.413 mg/L PBTK NA 95% Human Human -DTXSID0046513 Clint NA 698.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046513 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046513 Vd NA 15.73 L/kg 1compartment NA NA Rat Human -DTXSID0046513 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0046513 TK.Half.Life NA 4.348 hours 1compartment NA NA Rat Human -DTXSID0046513 Css NA 0.01968 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046513 Css NA 0.08565 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046513 Css NA 0.04146 mg/L PBTK NA 50% Rat Human -DTXSID0046513 Css NA 0.1878 mg/L PBTK NA 95% Rat Human -DTXSID0046517 Clint NA 6.788 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046517 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046517 Vd NA 1.15 L/kg 1compartment NA NA Human Human +DTXSID0046486 TK.Half.Life NA 3.206 hours 1compartment NA NA Rat Human +DTXSID0046486 Css NA 0.08078 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046486 Css NA 0.3783 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046486 Css NA 0.05417 mg/L PBTK NA 50% Rat Human +DTXSID0046486 Css NA 0.2321 mg/L PBTK NA 95% Rat Human +DTXSID0046488 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046488 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046488 Vd NA 2.92 L/kg 1compartment NA NA Human Human +DTXSID0046488 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID0046488 TK.Half.Life NA 44.98 hours 1compartment NA NA Human Human +DTXSID0046488 Css NA 1.711 mg/L 3compartmentss NA 50% Human Human +DTXSID0046488 Css NA 11.89 mg/L 3compartmentss NA 95% Human Human +DTXSID0046488 Css NA 1.166 mg/L PBTK NA 50% Human Human +DTXSID0046488 Css NA 7.74 mg/L PBTK NA 95% Human Human +DTXSID0046488 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046488 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046488 Vd NA 2.187 L/kg 1compartment NA NA Rat Human +DTXSID0046488 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID0046488 TK.Half.Life NA 7.904 hours 1compartment NA NA Rat Human +DTXSID0046488 Css NA 0.08592 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046488 Css NA 0.6124 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046488 Css NA 0.05712 mg/L PBTK NA 50% Rat Human +DTXSID0046488 Css NA 0.3899 mg/L PBTK NA 95% Rat Human +DTXSID0046517 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046517 Fup 0.835 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046517 Vd NA 0.7323 L/kg 1compartment NA NA Human Human DTXSID0046517 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046517 TK.Half.Life NA 1.117 hours 1compartment NA NA Human Human -DTXSID0046517 Css NA 0.06846 mg/L 3compartmentss NA 50% Human Human -DTXSID0046517 Css NA 0.6614 mg/L 3compartmentss NA 95% Human Human -DTXSID0046517 Css NA 0.05973 mg/L PBTK NA 50% Human Human -DTXSID0046517 Css NA 0.4923 mg/L PBTK NA 95% Human Human -DTXSID0046517 Clint NA 6.788 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046517 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046517 Vd NA 1.179 L/kg 1compartment NA NA Rat Human +DTXSID0046517 TK.Half.Life NA 5.682 hours 1compartment NA NA Human Human +DTXSID0046517 Css NA 0.8228 mg/L 3compartmentss NA 50% Human Human +DTXSID0046517 Css NA 4.897 mg/L 3compartmentss NA 95% Human Human +DTXSID0046517 Css NA 0.679 mg/L PBTK NA 50% Human Human +DTXSID0046517 Css NA 3.199 mg/L PBTK NA 95% Human Human +DTXSID0046517 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046517 Fup 0.835 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046517 Vd NA 0.7598 L/kg 1compartment NA NA Rat Human DTXSID0046517 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046517 TK.Half.Life NA 0.594 hours 1compartment NA NA Rat Human -DTXSID0046517 Css NA 0.03191 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046517 Css NA 0.2519 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046517 Css NA 0.02792 mg/L PBTK NA 50% Rat Human -DTXSID0046517 Css NA 0.1667 mg/L PBTK NA 95% Rat Human -DTXSID0046561 Clint NA 104.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046561 Fup NA 0.2907 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046561 Vd NA 1.872 L/kg 1compartment NA NA Human Human +DTXSID0046517 TK.Half.Life NA 2.007 hours 1compartment NA NA Rat Human +DTXSID0046517 Css NA 0.01526 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046517 Css NA 0.1143 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046517 Css NA 0.0121 mg/L PBTK NA 50% Rat Human +DTXSID0046517 Css NA 0.07464 mg/L PBTK NA 95% Rat Human +DTXSID0046561 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046561 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046561 Vd NA 1.435 L/kg 1compartment NA NA Human Human DTXSID0046561 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046561 TK.Half.Life NA 1.649 hours 1compartment NA NA Human Human -DTXSID0046561 Css NA 0.02003 mg/L 3compartmentss NA 50% Human Human -DTXSID0046561 Css NA 0.1439 mg/L 3compartmentss NA 95% Human Human -DTXSID0046561 Css NA 0.01537 mg/L PBTK NA 50% Human Human -DTXSID0046561 Css NA 0.09989 mg/L PBTK NA 95% Human Human -DTXSID0046561 Clint NA 104.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046561 Fup NA 0.2907 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046561 Vd NA 1.5 L/kg 1compartment NA NA Rat Human +DTXSID0046561 TK.Half.Life NA 6.762 hours 1compartment NA NA Human Human +DTXSID0046561 Css NA 0.5189 mg/L 3compartmentss NA 50% Human Human +DTXSID0046561 Css NA 3.121 mg/L 3compartmentss NA 95% Human Human +DTXSID0046561 Css NA 0.3608 mg/L PBTK NA 50% Human Human +DTXSID0046561 Css NA 2.033 mg/L PBTK NA 95% Human Human +DTXSID0046561 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046561 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046561 Vd NA 1.141 L/kg 1compartment NA NA Rat Human DTXSID0046561 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046561 TK.Half.Life NA 0.5889 hours 1compartment NA NA Rat Human -DTXSID0046561 Css NA 0.01083 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046561 Css NA 0.06369 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046561 Css NA 0.008047 mg/L PBTK NA 50% Rat Human -DTXSID0046561 Css NA 0.04452 mg/L PBTK NA 95% Rat Human -DTXSID0046563 Clint NA 124.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046563 Fup NA 0.2209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046563 Vd NA 3.407 L/kg 1compartment NA NA Human Human +DTXSID0046561 TK.Half.Life NA 2.771 hours 1compartment NA NA Rat Human +DTXSID0046561 Css NA 0.06304 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046561 Css NA 0.2761 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046561 Css NA 0.04348 mg/L PBTK NA 50% Rat Human +DTXSID0046561 Css NA 0.1754 mg/L PBTK NA 95% Rat Human +DTXSID0046563 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046563 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046563 Vd NA 3.509 L/kg 1compartment NA NA Human Human DTXSID0046563 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046563 TK.Half.Life NA 2.041 hours 1compartment NA NA Human Human -DTXSID0046563 Css NA 0.009542 mg/L 3compartmentss NA 50% Human Human -DTXSID0046563 Css NA 0.07976 mg/L 3compartmentss NA 95% Human Human -DTXSID0046563 Css NA 0.01048 mg/L PBTK NA 50% Human Human -DTXSID0046563 Css NA 0.07383 mg/L PBTK NA 95% Human Human -DTXSID0046563 Clint NA 124.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046563 Fup NA 0.2209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046563 Vd NA 3.418 L/kg 1compartment NA NA Rat Human +DTXSID0046563 TK.Half.Life NA 3.313 hours 1compartment NA NA Human Human +DTXSID0046563 Css NA 0.03658 mg/L 3compartmentss NA 50% Human Human +DTXSID0046563 Css NA 0.345 mg/L 3compartmentss NA 95% Human Human +DTXSID0046563 Css NA 0.04278 mg/L PBTK NA 50% Human Human +DTXSID0046563 Css NA 0.3165 mg/L PBTK NA 95% Human Human +DTXSID0046563 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046563 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046563 Vd NA 3.552 L/kg 1compartment NA NA Rat Human DTXSID0046563 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046563 TK.Half.Life NA 0.9786 hours 1compartment NA NA Rat Human -DTXSID0046563 Css NA 0.005064 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046563 Css NA 0.035 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046563 Css NA 0.005558 mg/L PBTK NA 50% Rat Human -DTXSID0046563 Css NA 0.03098 mg/L PBTK NA 95% Rat Human -DTXSID0046565 Clint NA 39.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046565 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046565 Vd NA 0.1922 L/kg 1compartment NA NA Human Human +DTXSID0046563 TK.Half.Life NA 1.847 hours 1compartment NA NA Rat Human +DTXSID0046563 Css NA 0.004434 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046563 Css NA 0.03045 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046563 Css NA 0.005382 mg/L PBTK NA 50% Rat Human +DTXSID0046563 Css NA 0.02847 mg/L PBTK NA 95% Rat Human +DTXSID0046565 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046565 Fup 0.032 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046565 Vd NA 0.3324 L/kg 1compartment NA NA Human Human DTXSID0046565 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046565 TK.Half.Life NA 4.156 hours 1compartment NA NA Human Human -DTXSID0046565 Css NA 3.99 mg/L 3compartmentss NA 50% Human Human -DTXSID0046565 Css NA 39.48 mg/L 3compartmentss NA 95% Human Human -DTXSID0046565 Css NA 2.314 mg/L PBTK NA 50% Human Human -DTXSID0046565 Css NA 22.97 mg/L PBTK NA 95% Human Human -DTXSID0046565 Clint NA 39.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046565 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046565 Vd NA 0.187 L/kg 1compartment NA NA Rat Human +DTXSID0046565 TK.Half.Life NA 6.139 hours 1compartment NA NA Human Human +DTXSID0046565 Css NA 3.165 mg/L 3compartmentss NA 50% Human Human +DTXSID0046565 Css NA 25.75 mg/L 3compartmentss NA 95% Human Human +DTXSID0046565 Css NA 1.949 mg/L PBTK NA 50% Human Human +DTXSID0046565 Css NA 15.25 mg/L PBTK NA 95% Human Human +DTXSID0046565 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046565 Fup 0.032 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046565 Vd NA 0.3217 L/kg 1compartment NA NA Rat Human DTXSID0046565 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046565 TK.Half.Life NA 2.747 hours 1compartment NA NA Rat Human -DTXSID0046565 Css NA 2.278 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046565 Css NA 18.69 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046565 Css NA 1.241 mg/L PBTK NA 50% Rat Human -DTXSID0046565 Css NA 10.13 mg/L PBTK NA 95% Rat Human -DTXSID0046567 Clint NA 11.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046567 Fup NA 0.2985 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046567 Vd NA 1.488 L/kg 1compartment NA NA Human Human +DTXSID0046565 TK.Half.Life NA 3.747 hours 1compartment NA NA Rat Human +DTXSID0046565 Css NA 0.3842 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046565 Css NA 2.543 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046565 Css NA 0.2293 mg/L PBTK NA 50% Rat Human +DTXSID0046565 Css NA 1.447 mg/L PBTK NA 95% Rat Human +DTXSID0046567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046567 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046567 Vd NA 1.1 L/kg 1compartment NA NA Human Human DTXSID0046567 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046567 TK.Half.Life NA 2.892 hours 1compartment NA NA Human Human -DTXSID0046567 Css NA 0.1504 mg/L 3compartmentss NA 50% Human Human -DTXSID0046567 Css NA 0.9765 mg/L 3compartmentss NA 95% Human Human -DTXSID0046567 Css NA 0.1144 mg/L PBTK NA 50% Human Human -DTXSID0046567 Css NA 0.6705 mg/L PBTK NA 95% Human Human -DTXSID0046567 Clint NA 11.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046567 Fup NA 0.2985 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046567 Vd NA 1.205 L/kg 1compartment NA NA Rat Human +DTXSID0046567 TK.Half.Life NA 2.092 hours 1compartment NA NA Human Human +DTXSID0046567 Css NA 0.147 mg/L 3compartmentss NA 50% Human Human +DTXSID0046567 Css NA 1.023 mg/L 3compartmentss NA 95% Human Human +DTXSID0046567 Css NA 0.1003 mg/L PBTK NA 50% Human Human +DTXSID0046567 Css NA 0.6524 mg/L PBTK NA 95% Human Human +DTXSID0046567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046567 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046567 Vd NA 0.8846 L/kg 1compartment NA NA Rat Human DTXSID0046567 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046567 TK.Half.Life NA 1.176 hours 1compartment NA NA Rat Human -DTXSID0046567 Css NA 0.08031 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046567 Css NA 0.3809 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046567 Css NA 0.05837 mg/L PBTK NA 50% Rat Human -DTXSID0046567 Css NA 0.2531 mg/L PBTK NA 95% Rat Human -DTXSID0046569 Clint NA 3.232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046569 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046569 Vd NA 0.9492 L/kg 1compartment NA NA Human Human +DTXSID0046567 TK.Half.Life NA 0.8965 hours 1compartment NA NA Rat Human +DTXSID0046567 Css NA 0.01872 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046567 Css NA 0.1031 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046567 Css NA 0.01263 mg/L PBTK NA 50% Rat Human +DTXSID0046567 Css NA 0.06582 mg/L PBTK NA 95% Rat Human +DTXSID0046569 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046569 Fup 0.757 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046569 Vd NA 0.725 L/kg 1compartment NA NA Human Human DTXSID0046569 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046569 TK.Half.Life NA 1.336 hours 1compartment NA NA Human Human -DTXSID0046569 Css NA 0.1318 mg/L 3compartmentss NA 50% Human Human -DTXSID0046569 Css NA 1.061 mg/L 3compartmentss NA 95% Human Human -DTXSID0046569 Css NA 0.114 mg/L PBTK NA 50% Human Human -DTXSID0046569 Css NA 0.7959 mg/L PBTK NA 95% Human Human -DTXSID0046569 Clint NA 3.232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046569 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046569 Vd NA 0.9606 L/kg 1compartment NA NA Rat Human +DTXSID0046569 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human +DTXSID0046569 Css NA 1.007 mg/L 3compartmentss NA 50% Human Human +DTXSID0046569 Css NA 6.04 mg/L 3compartmentss NA 95% Human Human +DTXSID0046569 Css NA 0.8222 mg/L PBTK NA 50% Human Human +DTXSID0046569 Css NA 3.89 mg/L PBTK NA 95% Human Human +DTXSID0046569 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046569 Fup 0.757 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046569 Vd NA 0.7465 L/kg 1compartment NA NA Rat Human DTXSID0046569 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046569 TK.Half.Life NA 0.7069 hours 1compartment NA NA Rat Human -DTXSID0046569 Css NA 0.0574 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046569 Css NA 0.4173 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046569 Css NA 0.04974 mg/L PBTK NA 50% Rat Human -DTXSID0046569 Css NA 0.2613 mg/L PBTK NA 95% Rat Human -DTXSID0046640 Clint NA 5.666 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046640 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046640 Vd NA 0.8075 L/kg 1compartment NA NA Human Human -DTXSID0046640 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0046640 TK.Half.Life NA 25.17 hours 1compartment NA NA Human Human -DTXSID0046640 Css NA 5.518 mg/L 3compartmentss NA 50% Human Human -DTXSID0046640 Css NA 47.14 mg/L 3compartmentss NA 95% Human Human -DTXSID0046640 Css NA 3.392 mg/L PBTK NA 50% Human Human -DTXSID0046640 Css NA 27.95 mg/L PBTK NA 95% Human Human -DTXSID0046640 Clint NA 5.666 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046640 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046640 Vd NA 0.6083 L/kg 1compartment NA NA Rat Human -DTXSID0046640 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0046640 TK.Half.Life NA 11.23 hours 1compartment NA NA Rat Human -DTXSID0046640 Css NA 2.915 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046640 Css NA 19.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046640 Css NA 1.662 mg/L PBTK NA 50% Rat Human -DTXSID0046640 Css NA 10.68 mg/L PBTK NA 95% Rat Human -DTXSID0046642 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046642 Fup NA 0.2172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046642 Vd NA 0.2768 L/kg 1compartment NA NA Human Human -DTXSID0046642 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046642 TK.Half.Life NA 8.245 hours 1compartment NA NA Human Human -DTXSID0046642 Css NA 3.786 mg/L 3compartmentss NA 50% Human Human -DTXSID0046642 Css NA 13.83 mg/L 3compartmentss NA 95% Human Human -DTXSID0046642 Css NA 2.421 mg/L PBTK NA 50% Human Human -DTXSID0046642 Css NA 8.274 mg/L PBTK NA 95% Human Human -DTXSID0046642 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046642 Fup NA 0.2172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046642 Vd NA 0.2811 L/kg 1compartment NA NA Rat Human +DTXSID0046569 TK.Half.Life NA 2.175 hours 1compartment NA NA Rat Human +DTXSID0046569 Css NA 0.05942 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046569 Css NA 0.3796 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046569 Css NA 0.04875 mg/L PBTK NA 50% Rat Human +DTXSID0046569 Css NA 0.2329 mg/L PBTK NA 95% Rat Human +DTXSID0046640 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046640 Fup 0.0184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046640 Vd NA 0.8007 L/kg 1compartment NA NA Human Human +DTXSID0046640 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0046640 TK.Half.Life NA 7.562 hours 1compartment NA NA Human Human +DTXSID0046640 Css NA 1.536 mg/L 3compartmentss NA 50% Human Human +DTXSID0046640 Css NA 15.72 mg/L 3compartmentss NA 95% Human Human +DTXSID0046640 Css NA 0.9332 mg/L PBTK NA 50% Human Human +DTXSID0046640 Css NA 9.236 mg/L PBTK NA 95% Human Human +DTXSID0046640 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046640 Fup 0.0184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046640 Vd NA 0.6034 L/kg 1compartment NA NA Rat Human +DTXSID0046640 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0046640 TK.Half.Life NA 3.497 hours 1compartment NA NA Rat Human +DTXSID0046640 Css NA 0.2007 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046640 Css NA 1.548 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046640 Css NA 0.1184 mg/L PBTK NA 50% Rat Human +DTXSID0046640 Css NA 0.8821 mg/L PBTK NA 95% Rat Human +DTXSID0046642 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046642 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046642 Vd NA 0.2088 L/kg 1compartment NA NA Human Human +DTXSID0046642 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0046642 TK.Half.Life NA 12.51 hours 1compartment NA NA Human Human +DTXSID0046642 Css NA 5.11 mg/L 3compartmentss NA 50% Human Human +DTXSID0046642 Css NA 25.17 mg/L 3compartmentss NA 95% Human Human +DTXSID0046642 Css NA 3.068 mg/L PBTK NA 50% Human Human +DTXSID0046642 Css NA 14.84 mg/L PBTK NA 95% Human Human +DTXSID0046642 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046642 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046642 Vd NA 0.2123 L/kg 1compartment NA NA Rat Human DTXSID0046642 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046642 TK.Half.Life NA 2.854 hours 1compartment NA NA Rat Human -DTXSID0046642 Css NA 1.064 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046642 Css NA 3.187 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046642 Css NA 0.6366 mg/L PBTK NA 50% Rat Human -DTXSID0046642 Css NA 1.787 mg/L PBTK NA 95% Rat Human -DTXSID0046644 Clint NA 0.2744 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046644 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046644 Vd NA 0.1915 L/kg 1compartment NA NA Human Human -DTXSID0046644 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID0046644 TK.Half.Life NA 52.51 hours 1compartment NA NA Human Human -DTXSID0046644 Css NA 46.94 mg/L 3compartmentss NA 50% Human Human -DTXSID0046644 Css NA 289.4 mg/L 3compartmentss NA 95% Human Human -DTXSID0046644 Css NA 27.62 mg/L PBTK NA 50% Human Human -DTXSID0046644 Css NA 168.7 mg/L PBTK NA 95% Human Human -DTXSID0046644 Clint NA 0.2744 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046644 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046644 Vd NA 0.1862 L/kg 1compartment NA NA Rat Human -DTXSID0046644 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0046644 TK.Half.Life NA 20.75 hours 1compartment NA NA Rat Human -DTXSID0046644 Css NA 15.96 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046644 Css NA 93.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046644 Css NA 8.728 mg/L PBTK NA 50% Rat Human -DTXSID0046644 Css NA 50.44 mg/L PBTK NA 95% Rat Human -DTXSID0046646 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046646 Fup NA 0.2714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046646 Vd NA 0.3159 L/kg 1compartment NA NA Human Human +DTXSID0046642 TK.Half.Life NA 4.335 hours 1compartment NA NA Rat Human +DTXSID0046642 Css NA 0.02809 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046642 Css NA 0.1344 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046642 Css NA 0.01583 mg/L PBTK NA 50% Rat Human +DTXSID0046642 Css NA 0.07439 mg/L PBTK NA 95% Rat Human +DTXSID0046644 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046644 Fup 0.0411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046644 Vd NA 0.2678 L/kg 1compartment NA NA Human Human +DTXSID0046644 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0046644 TK.Half.Life NA 3.883 hours 1compartment NA NA Human Human +DTXSID0046644 Css NA 2.529 mg/L 3compartmentss NA 50% Human Human +DTXSID0046644 Css NA 20.84 mg/L 3compartmentss NA 95% Human Human +DTXSID0046644 Css NA 1.518 mg/L PBTK NA 50% Human Human +DTXSID0046644 Css NA 12.01 mg/L PBTK NA 95% Human Human +DTXSID0046644 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046644 Fup 0.0411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046644 Vd NA 0.2516 L/kg 1compartment NA NA Rat Human +DTXSID0046644 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0046644 TK.Half.Life NA 2.286 hours 1compartment NA NA Rat Human +DTXSID0046644 Css NA 0.3102 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046644 Css NA 1.917 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046644 Css NA 0.1806 mg/L PBTK NA 50% Rat Human +DTXSID0046644 Css NA 1.083 mg/L PBTK NA 95% Rat Human +DTXSID0046646 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046646 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046646 Vd NA 0.3221 L/kg 1compartment NA NA Human Human DTXSID0046646 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046646 TK.Half.Life NA 7.53 hours 1compartment NA NA Human Human -DTXSID0046646 Css NA 2.972 mg/L 3compartmentss NA 50% Human Human -DTXSID0046646 Css NA 11.2 mg/L 3compartmentss NA 95% Human Human -DTXSID0046646 Css NA 1.949 mg/L PBTK NA 50% Human Human -DTXSID0046646 Css NA 6.78 mg/L PBTK NA 95% Human Human -DTXSID0046646 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046646 Fup NA 0.2714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046646 Vd NA 0.3198 L/kg 1compartment NA NA Rat Human +DTXSID0046646 TK.Half.Life NA 7.26 hours 1compartment NA NA Human Human +DTXSID0046646 Css NA 1.48 mg/L 3compartmentss NA 50% Human Human +DTXSID0046646 Css NA 6.116 mg/L 3compartmentss NA 95% Human Human +DTXSID0046646 Css NA 0.9789 mg/L PBTK NA 50% Human Human +DTXSID0046646 Css NA 3.71 mg/L PBTK NA 95% Human Human +DTXSID0046646 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046646 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046646 Vd NA 0.3265 L/kg 1compartment NA NA Rat Human DTXSID0046646 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046646 TK.Half.Life NA 2.598 hours 1compartment NA NA Rat Human -DTXSID0046646 Css NA 0.832 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046646 Css NA 2.622 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046646 Css NA 0.5142 mg/L PBTK NA 50% Rat Human -DTXSID0046646 Css NA 1.486 mg/L PBTK NA 95% Rat Human -DTXSID0046648 Clint NA 99.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046648 Fup NA 0.0258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046648 Vd NA 2.792 L/kg 1compartment NA NA Human Human -DTXSID0046648 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046648 TK.Half.Life NA 10.13 hours 1compartment NA NA Human Human -DTXSID0046648 Css NA 0.398 mg/L 3compartmentss NA 50% Human Human -DTXSID0046648 Css NA 2.657 mg/L 3compartmentss NA 95% Human Human -DTXSID0046648 Css NA 0.2698 mg/L PBTK NA 50% Human Human -DTXSID0046648 Css NA 1.725 mg/L PBTK NA 95% Human Human -DTXSID0046648 Clint NA 99.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046648 Fup NA 0.0258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046648 Vd NA 2.089 L/kg 1compartment NA NA Rat Human -DTXSID0046648 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046648 TK.Half.Life NA 2.262 hours 1compartment NA NA Rat Human -DTXSID0046648 Css NA 0.2245 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046648 Css NA 1.267 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046648 Css NA 0.1445 mg/L PBTK NA 50% Rat Human -DTXSID0046648 Css NA 0.7949 mg/L PBTK NA 95% Rat Human -DTXSID0046690 Clint NA 35.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046690 Fup NA 0.0532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046690 Vd NA 3.131 L/kg 1compartment NA NA Human Human -DTXSID0046690 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID0046690 TK.Half.Life NA 47.9 hours 1compartment NA NA Human Human -DTXSID0046690 Css NA 1.8 mg/L 3compartmentss NA 50% Human Human -DTXSID0046690 Css NA 11.51 mg/L 3compartmentss NA 95% Human Human -DTXSID0046690 Css NA 1.256 mg/L PBTK NA 50% Human Human -DTXSID0046690 Css NA 7.85 mg/L PBTK NA 95% Human Human -DTXSID0046690 Clint NA 35.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046690 Fup NA 0.0532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046690 Vd NA 2.35 L/kg 1compartment NA NA Rat Human -DTXSID0046690 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0046690 TK.Half.Life NA 6.717 hours 1compartment NA NA Rat Human -DTXSID0046690 Css NA 1.01 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046690 Css NA 5.482 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046690 Css NA 0.6712 mg/L PBTK NA 50% Rat Human -DTXSID0046690 Css NA 3.519 mg/L PBTK NA 95% Rat Human -DTXSID0046692 Clint NA 9.018 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046692 Fup NA 0.4825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046692 Vd NA 0.8148 L/kg 1compartment NA NA Human Human +DTXSID0046646 TK.Half.Life NA 2.508 hours 1compartment NA NA Rat Human +DTXSID0046646 Css NA 0.008145 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046646 Css NA 0.03361 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046646 Css NA 0.005101 mg/L PBTK NA 50% Rat Human +DTXSID0046646 Css NA 0.01941 mg/L PBTK NA 95% Rat Human +DTXSID0046648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046648 Fup 0.0172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046648 Vd NA 2.875 L/kg 1compartment NA NA Human Human +DTXSID0046648 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID0046648 TK.Half.Life NA 51.31 hours 1compartment NA NA Human Human +DTXSID0046648 Css NA 2.313 mg/L 3compartmentss NA 50% Human Human +DTXSID0046648 Css NA 16 mg/L 3compartmentss NA 95% Human Human +DTXSID0046648 Css NA 1.563 mg/L PBTK NA 50% Human Human +DTXSID0046648 Css NA 10.36 mg/L PBTK NA 95% Human Human +DTXSID0046648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046648 Fup 0.0172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046648 Vd NA 2.151 L/kg 1compartment NA NA Rat Human +DTXSID0046648 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0046648 TK.Half.Life NA 9.353 hours 1compartment NA NA Rat Human +DTXSID0046648 Css NA 0.2996 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046648 Css NA 1.762 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046648 Css NA 0.2003 mg/L PBTK NA 50% Rat Human +DTXSID0046648 Css NA 1.148 mg/L PBTK NA 95% Rat Human +DTXSID0046690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046690 Fup 0.073 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046690 Vd NA 3.12 L/kg 1compartment NA NA Human Human +DTXSID0046690 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID0046690 TK.Half.Life NA 54.88 hours 1compartment NA NA Human Human +DTXSID0046690 Css NA 2.015 mg/L 3compartmentss NA 50% Human Human +DTXSID0046690 Css NA 13.21 mg/L 3compartmentss NA 95% Human Human +DTXSID0046690 Css NA 1.41 mg/L PBTK NA 50% Human Human +DTXSID0046690 Css NA 8.993 mg/L PBTK NA 95% Human Human +DTXSID0046690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046690 Fup 0.073 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046690 Vd NA 2.349 L/kg 1compartment NA NA Rat Human +DTXSID0046690 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0046690 TK.Half.Life NA 7.939 hours 1compartment NA NA Rat Human +DTXSID0046690 Css NA 0.2626 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046690 Css NA 1.452 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046690 Css NA 0.1827 mg/L PBTK NA 50% Rat Human +DTXSID0046690 Css NA 0.9951 mg/L PBTK NA 95% Rat Human +DTXSID0046692 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046692 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046692 Vd NA 1.078 L/kg 1compartment NA NA Human Human DTXSID0046692 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046692 TK.Half.Life NA 1.182 hours 1compartment NA NA Human Human -DTXSID0046692 Css NA 0.09923 mg/L 3compartmentss NA 50% Human Human -DTXSID0046692 Css NA 0.7633 mg/L 3compartmentss NA 95% Human Human -DTXSID0046692 Css NA 0.07778 mg/L PBTK NA 50% Human Human -DTXSID0046692 Css NA 0.5204 mg/L PBTK NA 95% Human Human -DTXSID0046692 Clint NA 9.018 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046692 Fup NA 0.4825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046692 Vd NA 0.7684 L/kg 1compartment NA NA Rat Human +DTXSID0046692 TK.Half.Life NA 1.855 hours 1compartment NA NA Human Human +DTXSID0046692 Css NA 0.1242 mg/L 3compartmentss NA 50% Human Human +DTXSID0046692 Css NA 0.9815 mg/L 3compartmentss NA 95% Human Human +DTXSID0046692 Css NA 0.1011 mg/L PBTK NA 50% Human Human +DTXSID0046692 Css NA 0.6632 mg/L PBTK NA 95% Human Human +DTXSID0046692 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046692 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046692 Vd NA 0.9649 L/kg 1compartment NA NA Rat Human DTXSID0046692 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046692 TK.Half.Life NA 0.5986 hours 1compartment NA NA Rat Human -DTXSID0046692 Css NA 0.04964 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046692 Css NA 0.3095 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046692 Css NA 0.03768 mg/L PBTK NA 50% Rat Human -DTXSID0046692 Css NA 0.1924 mg/L PBTK NA 95% Rat Human +DTXSID0046692 TK.Half.Life NA 0.8832 hours 1compartment NA NA Rat Human +DTXSID0046692 Css NA 0.01459 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046692 Css NA 0.08759 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046692 Css NA 0.01191 mg/L PBTK NA 50% Rat Human +DTXSID0046692 Css NA 0.05802 mg/L PBTK NA 95% Rat Human DTXSID0046694 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0046694 Fup NA 0.9759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046694 Vd NA 1.093 L/kg 1compartment NA NA Human Human +DTXSID0046694 Vd NA 1.105 L/kg 1compartment NA NA Human Human DTXSID0046694 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046694 TK.Half.Life NA 7.25 hours 1compartment NA NA Human Human -DTXSID0046694 Css NA 0.8358 mg/L 3compartmentss NA 50% Human Human -DTXSID0046694 Css NA 4.753 mg/L 3compartmentss NA 95% Human Human -DTXSID0046694 Css NA 0.7368 mg/L PBTK NA 50% Human Human -DTXSID0046694 Css NA 3.185 mg/L PBTK NA 95% Human Human +DTXSID0046694 TK.Half.Life NA 7.329 hours 1compartment NA NA Human Human +DTXSID0046694 Css NA 0.4561 mg/L 3compartmentss NA 50% Human Human +DTXSID0046694 Css NA 2.747 mg/L 3compartmentss NA 95% Human Human +DTXSID0046694 Css NA 0.4007 mg/L PBTK NA 50% Human Human +DTXSID0046694 Css NA 1.888 mg/L PBTK NA 95% Human Human DTXSID0046694 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0046694 Fup NA 0.9759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046694 Vd NA 1.134 L/kg 1compartment NA NA Rat Human +DTXSID0046694 Vd NA 1.145 L/kg 1compartment NA NA Rat Human DTXSID0046694 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046694 TK.Half.Life NA 2.562 hours 1compartment NA NA Rat Human -DTXSID0046694 Css NA 0.2117 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046694 Css NA 1.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046694 Css NA 0.1819 mg/L PBTK NA 50% Rat Human -DTXSID0046694 Css NA 0.753 mg/L PBTK NA 95% Rat Human -DTXSID0046696 Clint NA 25.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046696 Fup NA 0.1214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046696 Vd NA 1.002 L/kg 1compartment NA NA Human Human +DTXSID0046694 TK.Half.Life NA 2.587 hours 1compartment NA NA Rat Human +DTXSID0046694 Css NA 0.002367 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046694 Css NA 0.01513 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046694 Css NA 0.002033 mg/L PBTK NA 50% Rat Human +DTXSID0046694 Css NA 0.00966 mg/L PBTK NA 95% Rat Human +DTXSID0046696 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046696 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046696 Vd NA 0.3928 L/kg 1compartment NA NA Human Human DTXSID0046696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046696 TK.Half.Life NA 2.077 hours 1compartment NA NA Human Human -DTXSID0046696 Css NA 0.199 mg/L 3compartmentss NA 50% Human Human -DTXSID0046696 Css NA 1.601 mg/L 3compartmentss NA 95% Human Human -DTXSID0046696 Css NA 0.1315 mg/L PBTK NA 50% Human Human -DTXSID0046696 Css NA 0.9978 mg/L PBTK NA 95% Human Human -DTXSID0046696 Clint NA 25.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046696 Fup NA 0.1214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046696 Vd NA 0.8233 L/kg 1compartment NA NA Rat Human +DTXSID0046696 TK.Half.Life NA 0.8096 hours 1compartment NA NA Human Human +DTXSID0046696 Css NA 0.1461 mg/L 3compartmentss NA 50% Human Human +DTXSID0046696 Css NA 1.037 mg/L 3compartmentss NA 95% Human Human +DTXSID0046696 Css NA 0.1009 mg/L PBTK NA 50% Human Human +DTXSID0046696 Css NA 0.67 mg/L PBTK NA 95% Human Human +DTXSID0046696 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046696 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046696 Vd NA 0.397 L/kg 1compartment NA NA Rat Human DTXSID0046696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046696 TK.Half.Life NA 0.9383 hours 1compartment NA NA Rat Human -DTXSID0046696 Css NA 0.1114 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046696 Css NA 0.7106 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046696 Css NA 0.06973 mg/L PBTK NA 50% Rat Human -DTXSID0046696 Css NA 0.4113 mg/L PBTK NA 95% Rat Human -DTXSID0046698 Clint NA 49.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046698 Fup NA 0.0717 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046698 Vd NA 2.29 L/kg 1compartment NA NA Human Human +DTXSID0046696 TK.Half.Life NA 0.4533 hours 1compartment NA NA Rat Human +DTXSID0046696 Css NA 0.006508 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046696 Css NA 0.05114 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046696 Css NA 0.004414 mg/L PBTK NA 50% Rat Human +DTXSID0046696 Css NA 0.03164 mg/L PBTK NA 95% Rat Human +DTXSID0046698 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046698 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046698 Vd NA 2.709 L/kg 1compartment NA NA Human Human DTXSID0046698 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046698 TK.Half.Life NA 4.578 hours 1compartment NA NA Human Human -DTXSID0046698 Css NA 0.1595 mg/L 3compartmentss NA 50% Human Human -DTXSID0046698 Css NA 1.074 mg/L 3compartmentss NA 95% Human Human -DTXSID0046698 Css NA 0.1152 mg/L PBTK NA 50% Human Human -DTXSID0046698 Css NA 0.7309 mg/L PBTK NA 95% Human Human -DTXSID0046698 Clint NA 49.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046698 Fup NA 0.0717 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046698 Vd NA 1.871 L/kg 1compartment NA NA Rat Human +DTXSID0046698 TK.Half.Life NA 6.022 hours 1compartment NA NA Human Human +DTXSID0046698 Css NA 0.1822 mg/L 3compartmentss NA 50% Human Human +DTXSID0046698 Css NA 1.392 mg/L 3compartmentss NA 95% Human Human +DTXSID0046698 Css NA 0.1445 mg/L PBTK NA 50% Human Human +DTXSID0046698 Css NA 0.9925 mg/L PBTK NA 95% Human Human +DTXSID0046698 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046698 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046698 Vd NA 2.29 L/kg 1compartment NA NA Rat Human DTXSID0046698 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046698 TK.Half.Life NA 1.714 hours 1compartment NA NA Rat Human -DTXSID0046698 Css NA 0.0894 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046698 Css NA 0.4671 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046698 Css NA 0.06166 mg/L PBTK NA 50% Rat Human -DTXSID0046698 Css NA 0.3069 mg/L PBTK NA 95% Rat Human -DTXSID0046721 Clint NA 22.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046721 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046721 Vd NA 2.669 L/kg 1compartment NA NA Human Human -DTXSID0046721 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0046721 TK.Half.Life NA 22.29 hours 1compartment NA NA Human Human -DTXSID0046721 Css NA 1.092 mg/L 3compartmentss NA 50% Human Human -DTXSID0046721 Css NA 7.732 mg/L 3compartmentss NA 95% Human Human -DTXSID0046721 Css NA 0.7512 mg/L PBTK NA 50% Human Human -DTXSID0046721 Css NA 5.105 mg/L PBTK NA 95% Human Human -DTXSID0046721 Clint NA 22.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046721 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046721 Vd NA 2.04 L/kg 1compartment NA NA Rat Human -DTXSID0046721 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0046721 TK.Half.Life NA 5.55 hours 1compartment NA NA Rat Human -DTXSID0046721 Css NA 0.6208 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046721 Css NA 3.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046721 Css NA 0.4038 mg/L PBTK NA 50% Rat Human -DTXSID0046721 Css NA 2.147 mg/L PBTK NA 95% Rat Human +DTXSID0046698 TK.Half.Life NA 2.227 hours 1compartment NA NA Rat Human +DTXSID0046698 Css NA 0.02309 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046698 Css NA 0.1314 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046698 Css NA 0.01823 mg/L PBTK NA 50% Rat Human +DTXSID0046698 Css NA 0.09457 mg/L PBTK NA 95% Rat Human +DTXSID0046721 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046721 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046721 Vd NA 2.54 L/kg 1compartment NA NA Human Human +DTXSID0046721 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0046721 TK.Half.Life NA 32.8 hours 1compartment NA NA Human Human +DTXSID0046721 Css NA 1.646 mg/L 3compartmentss NA 50% Human Human +DTXSID0046721 Css NA 9.337 mg/L 3compartmentss NA 95% Human Human +DTXSID0046721 Css NA 1.133 mg/L PBTK NA 50% Human Human +DTXSID0046721 Css NA 6.119 mg/L PBTK NA 95% Human Human +DTXSID0046721 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046721 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046721 Vd NA 1.915 L/kg 1compartment NA NA Rat Human +DTXSID0046721 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0046721 TK.Half.Life NA 7.776 hours 1compartment NA NA Rat Human +DTXSID0046721 Css NA 0.1997 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046721 Css NA 0.8343 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046721 Css NA 0.1361 mg/L PBTK NA 50% Rat Human +DTXSID0046721 Css NA 0.5404 mg/L PBTK NA 95% Rat Human DTXSID0046723 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0046723 Fup NA 0.1002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046723 Vd NA 0.2864 L/kg 1compartment NA NA Human Human -DTXSID0046723 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0046723 TK.Half.Life NA 18.52 hours 1compartment NA NA Human Human -DTXSID0046723 Css NA 10.2 mg/L 3compartmentss NA 50% Human Human -DTXSID0046723 Css NA 46.43 mg/L 3compartmentss NA 95% Human Human -DTXSID0046723 Css NA 6.238 mg/L PBTK NA 50% Human Human -DTXSID0046723 Css NA 27.42 mg/L PBTK NA 95% Human Human +DTXSID0046723 Vd NA 0.2344 L/kg 1compartment NA NA Human Human +DTXSID0046723 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0046723 TK.Half.Life NA 15.13 hours 1compartment NA NA Human Human +DTXSID0046723 Css NA 8.762 mg/L 3compartmentss NA 50% Human Human +DTXSID0046723 Css NA 40.48 mg/L 3compartmentss NA 95% Human Human +DTXSID0046723 Css NA 5.31 mg/L PBTK NA 50% Human Human +DTXSID0046723 Css NA 23.8 mg/L PBTK NA 95% Human Human DTXSID0046723 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0046723 Fup NA 0.1002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046723 Vd NA 0.2844 L/kg 1compartment NA NA Rat Human +DTXSID0046723 Vd NA 0.243 L/kg 1compartment NA NA Rat Human DTXSID0046723 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046723 TK.Half.Life NA 6.256 hours 1compartment NA NA Rat Human -DTXSID0046723 Css NA 2.874 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046723 Css NA 11.11 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046723 Css NA 1.649 mg/L PBTK NA 50% Rat Human -DTXSID0046723 Css NA 6.099 mg/L PBTK NA 95% Rat Human -DTXSID0046725 Clint NA 0.8378 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046725 Fup NA 0.0931 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046725 Vd NA 0.8151 L/kg 1compartment NA NA Human Human -DTXSID0046725 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0046725 TK.Half.Life NA 24.01 hours 1compartment NA NA Human Human -DTXSID0046725 Css NA 4.426 mg/L 3compartmentss NA 50% Human Human -DTXSID0046725 Css NA 22.83 mg/L 3compartmentss NA 95% Human Human -DTXSID0046725 Css NA 2.891 mg/L PBTK NA 50% Human Human -DTXSID0046725 Css NA 13.7 mg/L PBTK NA 95% Human Human -DTXSID0046725 Clint NA 0.8378 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046725 Fup NA 0.0931 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046725 Vd NA 0.7501 L/kg 1compartment NA NA Rat Human -DTXSID0046725 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0046725 TK.Half.Life NA 10.55 hours 1compartment NA NA Rat Human -DTXSID0046725 Css NA 1.792 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046725 Css NA 7.602 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046725 Css NA 1.1 mg/L PBTK NA 50% Rat Human -DTXSID0046725 Css NA 4.256 mg/L PBTK NA 95% Rat Human -DTXSID0046727 Clint NA 148.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046727 Fup NA 0.025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046727 Vd NA 0.3932 L/kg 1compartment NA NA Human Human +DTXSID0046723 TK.Half.Life NA 5.348 hours 1compartment NA NA Rat Human +DTXSID0046723 Css NA 0.1601 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046723 Css NA 1.061 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046723 Css NA 0.09202 mg/L PBTK NA 50% Rat Human +DTXSID0046723 Css NA 0.5989 mg/L PBTK NA 95% Rat Human +DTXSID0046725 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046725 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046725 Vd NA 0.947 L/kg 1compartment NA NA Human Human +DTXSID0046725 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0046725 TK.Half.Life NA 3.868 hours 1compartment NA NA Human Human +DTXSID0046725 Css NA 0.41 mg/L 3compartmentss NA 50% Human Human +DTXSID0046725 Css NA 2.491 mg/L 3compartmentss NA 95% Human Human +DTXSID0046725 Css NA 0.2876 mg/L PBTK NA 50% Human Human +DTXSID0046725 Css NA 1.651 mg/L PBTK NA 95% Human Human +DTXSID0046725 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046725 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046725 Vd NA 0.9015 L/kg 1compartment NA NA Rat Human +DTXSID0046725 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0046725 TK.Half.Life NA 2.174 hours 1compartment NA NA Rat Human +DTXSID0046725 Css NA 0.04923 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046725 Css NA 0.2134 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046725 Css NA 0.03435 mg/L PBTK NA 50% Rat Human +DTXSID0046725 Css NA 0.1361 mg/L PBTK NA 95% Rat Human +DTXSID0046727 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046727 Fup 0.0579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046727 Vd NA 0.8137 L/kg 1compartment NA NA Human Human DTXSID0046727 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046727 TK.Half.Life NA 0.7645 hours 1compartment NA NA Human Human -DTXSID0046727 Css NA 0.1898 mg/L 3compartmentss NA 50% Human Human -DTXSID0046727 Css NA 1.959 mg/L 3compartmentss NA 95% Human Human -DTXSID0046727 Css NA 0.1133 mg/L PBTK NA 50% Human Human -DTXSID0046727 Css NA 1.138 mg/L PBTK NA 95% Human Human -DTXSID0046727 Clint NA 148.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046727 Fup NA 0.025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046727 Vd NA 0.3187 L/kg 1compartment NA NA Rat Human +DTXSID0046727 TK.Half.Life NA 8.58 hours 1compartment NA NA Human Human +DTXSID0046727 Css NA 1.458 mg/L 3compartmentss NA 50% Human Human +DTXSID0046727 Css NA 10.17 mg/L 3compartmentss NA 95% Human Human +DTXSID0046727 Css NA 0.92 mg/L PBTK NA 50% Human Human +DTXSID0046727 Css NA 6.113 mg/L PBTK NA 95% Human Human +DTXSID0046727 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046727 Fup 0.0579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046727 Vd NA 0.6281 L/kg 1compartment NA NA Rat Human DTXSID0046727 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046727 TK.Half.Life NA 0.3495 hours 1compartment NA NA Rat Human -DTXSID0046727 Css NA 0.1094 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046727 Css NA 0.896 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046727 Css NA 0.06084 mg/L PBTK NA 50% Rat Human -DTXSID0046727 Css NA 0.4877 mg/L PBTK NA 95% Rat Human +DTXSID0046727 TK.Half.Life NA 3.87 hours 1compartment NA NA Rat Human +DTXSID0046727 Css NA 0.06749 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046727 Css NA 0.4962 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046727 Css NA 0.04054 mg/L PBTK NA 50% Rat Human +DTXSID0046727 Css NA 0.2881 mg/L PBTK NA 95% Rat Human DTXSID0046729 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0046729 Fup NA 0.1001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046729 Vd NA 0.2202 L/kg 1compartment NA NA Human Human +DTXSID0046729 Vd NA 0.211 L/kg 1compartment NA NA Human Human DTXSID0046729 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0046729 TK.Half.Life NA 14.24 hours 1compartment NA NA Human Human -DTXSID0046729 Css NA 10.3 mg/L 3compartmentss NA 50% Human Human -DTXSID0046729 Css NA 47.09 mg/L 3compartmentss NA 95% Human Human -DTXSID0046729 Css NA 6.212 mg/L PBTK NA 50% Human Human -DTXSID0046729 Css NA 27.25 mg/L PBTK NA 95% Human Human +DTXSID0046729 TK.Half.Life NA 13.64 hours 1compartment NA NA Human Human +DTXSID0046729 Css NA 8.866 mg/L 3compartmentss NA 50% Human Human +DTXSID0046729 Css NA 40.18 mg/L 3compartmentss NA 95% Human Human +DTXSID0046729 Css NA 5.329 mg/L PBTK NA 50% Human Human +DTXSID0046729 Css NA 23.39 mg/L PBTK NA 95% Human Human DTXSID0046729 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0046729 Fup NA 0.1001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046729 Vd NA 0.2246 L/kg 1compartment NA NA Rat Human +DTXSID0046729 Vd NA 0.2169 L/kg 1compartment NA NA Rat Human DTXSID0046729 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046729 TK.Half.Life NA 4.948 hours 1compartment NA NA Rat Human -DTXSID0046729 Css NA 2.918 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046729 Css NA 11.16 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046729 Css NA 1.642 mg/L PBTK NA 50% Rat Human -DTXSID0046729 Css NA 6.094 mg/L PBTK NA 95% Rat Human -DTXSID0046773 Clint NA 9.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046773 Fup NA 0.0764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046773 Vd NA 1.363 L/kg 1compartment NA NA Human Human +DTXSID0046729 TK.Half.Life NA 4.777 hours 1compartment NA NA Rat Human +DTXSID0046729 Css NA 0.1629 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046729 Css NA 1.089 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046729 Css NA 0.093 mg/L PBTK NA 50% Rat Human +DTXSID0046729 Css NA 0.612 mg/L PBTK NA 95% Rat Human +DTXSID0046773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046773 Fup 0.0974 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046773 Vd NA 1.139 L/kg 1compartment NA NA Human Human DTXSID0046773 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046773 TK.Half.Life NA 8.534 hours 1compartment NA NA Human Human -DTXSID0046773 Css NA 0.8872 mg/L 3compartmentss NA 50% Human Human -DTXSID0046773 Css NA 6.095 mg/L 3compartmentss NA 95% Human Human -DTXSID0046773 Css NA 0.577 mg/L PBTK NA 50% Human Human -DTXSID0046773 Css NA 3.748 mg/L PBTK NA 95% Human Human -DTXSID0046773 Clint NA 9.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046773 Fup NA 0.0764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046773 Vd NA 1.034 L/kg 1compartment NA NA Rat Human +DTXSID0046773 TK.Half.Life NA 3.108 hours 1compartment NA NA Human Human +DTXSID0046773 Css NA 0.297 mg/L 3compartmentss NA 50% Human Human +DTXSID0046773 Css NA 2.391 mg/L 3compartmentss NA 95% Human Human +DTXSID0046773 Css NA 0.1938 mg/L PBTK NA 50% Human Human +DTXSID0046773 Css NA 1.482 mg/L PBTK NA 95% Human Human +DTXSID0046773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046773 Fup 0.0974 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046773 Vd NA 0.8783 L/kg 1compartment NA NA Rat Human DTXSID0046773 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046773 TK.Half.Life NA 3.394 hours 1compartment NA NA Rat Human -DTXSID0046773 Css NA 0.4792 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046773 Css NA 2.478 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046773 Css NA 0.2945 mg/L PBTK NA 50% Rat Human -DTXSID0046773 Css NA 1.447 mg/L PBTK NA 95% Rat Human -DTXSID0046777 Clint NA 13.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046777 Fup NA 0.0881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046777 Vd NA 0.3393 L/kg 1compartment NA NA Human Human +DTXSID0046773 TK.Half.Life NA 1.298 hours 1compartment NA NA Rat Human +DTXSID0046773 Css NA 0.03835 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046773 Css NA 0.2389 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046773 Css NA 0.02459 mg/L PBTK NA 50% Rat Human +DTXSID0046773 Css NA 0.1423 mg/L PBTK NA 95% Rat Human +DTXSID0046777 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046777 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046777 Vd NA 0.3787 L/kg 1compartment NA NA Human Human DTXSID0046777 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046777 TK.Half.Life NA 1.377 hours 1compartment NA NA Human Human -DTXSID0046777 Css NA 0.555 mg/L 3compartmentss NA 50% Human Human -DTXSID0046777 Css NA 4.415 mg/L 3compartmentss NA 95% Human Human -DTXSID0046777 Css NA 0.3506 mg/L PBTK NA 50% Human Human -DTXSID0046777 Css NA 2.675 mg/L PBTK NA 95% Human Human -DTXSID0046777 Clint NA 13.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046777 Fup NA 0.0881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046777 Vd NA 0.3308 L/kg 1compartment NA NA Rat Human +DTXSID0046777 TK.Half.Life NA 1.727 hours 1compartment NA NA Human Human +DTXSID0046777 Css NA 0.2942 mg/L 3compartmentss NA 50% Human Human +DTXSID0046777 Css NA 2.326 mg/L 3compartmentss NA 95% Human Human +DTXSID0046777 Css NA 0.1928 mg/L PBTK NA 50% Human Human +DTXSID0046777 Css NA 1.446 mg/L PBTK NA 95% Human Human +DTXSID0046777 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046777 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046777 Vd NA 0.3726 L/kg 1compartment NA NA Rat Human DTXSID0046777 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046777 TK.Half.Life NA 0.8274 hours 1compartment NA NA Rat Human -DTXSID0046777 Css NA 0.3046 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046777 Css NA 1.657 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046777 Css NA 0.1807 mg/L PBTK NA 50% Rat Human -DTXSID0046777 Css NA 0.9324 mg/L PBTK NA 95% Rat Human -DTXSID0046779 Clint NA 90.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0046777 TK.Half.Life NA 1.018 hours 1compartment NA NA Rat Human +DTXSID0046777 Css NA 0.003002 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046777 Css NA 0.01967 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046777 Css NA 0.001867 mg/L PBTK NA 50% Rat Human +DTXSID0046777 Css NA 0.01132 mg/L PBTK NA 95% Rat Human +DTXSID0046779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0046779 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0046779 Vd NA 0.6331 L/kg 1compartment NA NA Human Human +DTXSID0046779 Vd NA 0.3507 L/kg 1compartment NA NA Human Human DTXSID0046779 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046779 TK.Half.Life NA 1.101 hours 1compartment NA NA Human Human -DTXSID0046779 Css NA 0.1508 mg/L 3compartmentss NA 50% Human Human -DTXSID0046779 Css NA 1.321 mg/L 3compartmentss NA 95% Human Human -DTXSID0046779 Css NA 0.09188 mg/L PBTK NA 50% Human Human -DTXSID0046779 Css NA 0.7756 mg/L PBTK NA 95% Human Human -DTXSID0046779 Clint NA 90.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0046779 TK.Half.Life NA 1.513 hours 1compartment NA NA Human Human +DTXSID0046779 Css NA 0.6124 mg/L 3compartmentss NA 50% Human Human +DTXSID0046779 Css NA 5.201 mg/L 3compartmentss NA 95% Human Human +DTXSID0046779 Css NA 0.3682 mg/L PBTK NA 50% Human Human +DTXSID0046779 Css NA 3.098 mg/L PBTK NA 95% Human Human +DTXSID0046779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0046779 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0046779 Vd NA 0.4968 L/kg 1compartment NA NA Rat Human +DTXSID0046779 Vd NA 0.3038 L/kg 1compartment NA NA Rat Human DTXSID0046779 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046779 TK.Half.Life NA 0.4702 hours 1compartment NA NA Rat Human -DTXSID0046779 Css NA 0.08589 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046779 Css NA 0.6398 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046779 Css NA 0.04906 mg/L PBTK NA 50% Rat Human -DTXSID0046779 Css NA 0.3579 mg/L PBTK NA 95% Rat Human -DTXSID0046800 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046800 Fup NA 0.2584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046800 Vd NA 0.299 L/kg 1compartment NA NA Human Human +DTXSID0046779 TK.Half.Life NA 0.8165 hours 1compartment NA NA Rat Human +DTXSID0046779 Css NA 0.08034 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046779 Css NA 0.5246 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046779 Css NA 0.04674 mg/L PBTK NA 50% Rat Human +DTXSID0046779 Css NA 0.2965 mg/L PBTK NA 95% Rat Human +DTXSID0046800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046800 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046800 Vd NA 0.2799 L/kg 1compartment NA NA Human Human DTXSID0046800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046800 TK.Half.Life NA 7.487 hours 1compartment NA NA Human Human -DTXSID0046800 Css NA 3.148 mg/L 3compartmentss NA 50% Human Human -DTXSID0046800 Css NA 11.79 mg/L 3compartmentss NA 95% Human Human -DTXSID0046800 Css NA 2.046 mg/L PBTK NA 50% Human Human -DTXSID0046800 Css NA 7.18 mg/L PBTK NA 95% Human Human -DTXSID0046800 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046800 Fup NA 0.2584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046800 Vd NA 0.3046 L/kg 1compartment NA NA Rat Human +DTXSID0046800 TK.Half.Life NA 0.8461 hours 1compartment NA NA Human Human +DTXSID0046800 Css NA 0.1564 mg/L 3compartmentss NA 50% Human Human +DTXSID0046800 Css NA 1.023 mg/L 3compartmentss NA 95% Human Human +DTXSID0046800 Css NA 0.09992 mg/L PBTK NA 50% Human Human +DTXSID0046800 Css NA 0.6247 mg/L PBTK NA 95% Human Human +DTXSID0046800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046800 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046800 Vd NA 0.2863 L/kg 1compartment NA NA Rat Human DTXSID0046800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046800 TK.Half.Life NA 2.599 hours 1compartment NA NA Rat Human -DTXSID0046800 Css NA 0.8801 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046800 Css NA 2.679 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046800 Css NA 0.5384 mg/L PBTK NA 50% Rat Human -DTXSID0046800 Css NA 1.515 mg/L PBTK NA 95% Rat Human -DTXSID0046804 Clint NA 5.893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046804 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046804 Vd NA 1.488 L/kg 1compartment NA NA Human Human -DTXSID0046804 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0046804 TK.Half.Life NA 21.57 hours 1compartment NA NA Human Human -DTXSID0046804 Css NA 2.264 mg/L 3compartmentss NA 50% Human Human -DTXSID0046804 Css NA 15.78 mg/L 3compartmentss NA 95% Human Human -DTXSID0046804 Css NA 1.454 mg/L PBTK NA 50% Human Human -DTXSID0046804 Css NA 9.625 mg/L PBTK NA 95% Human Human -DTXSID0046804 Clint NA 5.893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046804 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046804 Vd NA 1.119 L/kg 1compartment NA NA Rat Human -DTXSID0046804 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0046804 TK.Half.Life NA 8.128 hours 1compartment NA NA Rat Human -DTXSID0046804 Css NA 1.204 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046804 Css NA 6.081 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046804 Css NA 0.7264 mg/L PBTK NA 50% Rat Human -DTXSID0046804 Css NA 3.475 mg/L PBTK NA 95% Rat Human -DTXSID0046806 Clint NA 78.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046806 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046806 Vd NA 9.55 L/kg 1compartment NA NA Human Human -DTXSID0046806 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID0046806 TK.Half.Life NA 82.4 hours 1compartment NA NA Human Human -DTXSID0046806 Css NA 0.5804 mg/L 3compartmentss NA 50% Human Human -DTXSID0046806 Css NA 3.4 mg/L 3compartmentss NA 95% Human Human -DTXSID0046806 Css NA 0.67 mg/L PBTK NA 50% Human Human -DTXSID0046806 Css NA 3.842 mg/L PBTK NA 95% Human Human -DTXSID0046806 Clint NA 78.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046806 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046806 Vd NA 7.503 L/kg 1compartment NA NA Rat Human -DTXSID0046806 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID0046806 TK.Half.Life NA 12.04 hours 1compartment NA NA Rat Human -DTXSID0046806 Css NA 0.3154 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046806 Css NA 1.373 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046806 Css NA 0.3648 mg/L PBTK NA 50% Rat Human -DTXSID0046806 Css NA 1.511 mg/L PBTK NA 95% Rat Human -DTXSID0046808 Clint NA 31.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046808 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046808 Vd NA 0.9558 L/kg 1compartment NA NA Human Human +DTXSID0046800 TK.Half.Life NA 0.5001 hours 1compartment NA NA Rat Human +DTXSID0046800 Css NA 0.00152 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046800 Css NA 0.008607 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046800 Css NA 0.0009228 mg/L PBTK NA 50% Rat Human +DTXSID0046800 Css NA 0.004996 mg/L PBTK NA 95% Rat Human +DTXSID0046804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046804 Fup 0.0264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046804 Vd NA 2.125 L/kg 1compartment NA NA Human Human +DTXSID0046804 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0046804 TK.Half.Life NA 18.79 hours 1compartment NA NA Human Human +DTXSID0046804 Css NA 1.272 mg/L 3compartmentss NA 50% Human Human +DTXSID0046804 Css NA 9.791 mg/L 3compartmentss NA 95% Human Human +DTXSID0046804 Css NA 0.8304 mg/L PBTK NA 50% Human Human +DTXSID0046804 Css NA 6.018 mg/L PBTK NA 95% Human Human +DTXSID0046804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046804 Fup 0.0264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046804 Vd NA 1.583 L/kg 1compartment NA NA Rat Human +DTXSID0046804 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0046804 TK.Half.Life NA 5.738 hours 1compartment NA NA Rat Human +DTXSID0046804 Css NA 0.163 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046804 Css NA 1.061 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046804 Css NA 0.1039 mg/L PBTK NA 50% Rat Human +DTXSID0046804 Css NA 0.6401 mg/L PBTK NA 95% Rat Human +DTXSID0046806 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046806 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046806 Vd NA 11.66 L/kg 1compartment NA NA Human Human +DTXSID0046806 Days.Css NA 74 Days PBTK NA NA Human Human +DTXSID0046806 TK.Half.Life NA 347.3 hours 1compartment NA NA Human Human +DTXSID0046806 Css NA 1.781 mg/L 3compartmentss NA 50% Human Human +DTXSID0046806 Css NA 10.93 mg/L 3compartmentss NA 95% Human Human +DTXSID0046806 Css NA 2.367 mg/L PBTK NA 50% Human Human +DTXSID0046806 Css NA 14.33 mg/L PBTK NA 95% Human Human +DTXSID0046806 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046806 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046806 Vd NA 9.25 L/kg 1compartment NA NA Rat Human +DTXSID0046806 Days.Css NA 44 Days PBTK NA NA Rat Human +DTXSID0046806 TK.Half.Life NA 48.3 hours 1compartment NA NA Rat Human +DTXSID0046806 Css NA 0.2219 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046806 Css NA 1.029 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046806 Css NA 0.3067 mg/L PBTK NA 50% Rat Human +DTXSID0046806 Css NA 1.496 mg/L PBTK NA 95% Rat Human +DTXSID0046808 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046808 Fup 0.0607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046808 Vd NA 1.526 L/kg 1compartment NA NA Human Human DTXSID0046808 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046808 TK.Half.Life NA 5.527 hours 1compartment NA NA Human Human -DTXSID0046808 Css NA 0.8882 mg/L 3compartmentss NA 50% Human Human -DTXSID0046808 Css NA 8.442 mg/L 3compartmentss NA 95% Human Human -DTXSID0046808 Css NA 0.5403 mg/L PBTK NA 50% Human Human -DTXSID0046808 Css NA 4.954 mg/L PBTK NA 95% Human Human -DTXSID0046808 Clint NA 31.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046808 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046808 Vd NA 0.7171 L/kg 1compartment NA NA Rat Human +DTXSID0046808 TK.Half.Life NA 6.239 hours 1compartment NA NA Human Human +DTXSID0046808 Css NA 0.5376 mg/L 3compartmentss NA 50% Human Human +DTXSID0046808 Css NA 3.761 mg/L 3compartmentss NA 95% Human Human +DTXSID0046808 Css NA 0.3456 mg/L PBTK NA 50% Human Human +DTXSID0046808 Css NA 2.291 mg/L PBTK NA 95% Human Human +DTXSID0046808 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046808 Fup 0.0607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046808 Vd NA 1.154 L/kg 1compartment NA NA Rat Human DTXSID0046808 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046808 TK.Half.Life NA 2.442 hours 1compartment NA NA Rat Human -DTXSID0046808 Css NA 0.5108 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046808 Css NA 3.994 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046808 Css NA 0.2916 mg/L PBTK NA 50% Rat Human -DTXSID0046808 Css NA 2.203 mg/L PBTK NA 95% Rat Human -DTXSID0046850 Clint NA 27.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046850 Fup NA 0.4274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046850 Vd NA 2.933 L/kg 1compartment NA NA Human Human +DTXSID0046808 TK.Half.Life NA 2.402 hours 1compartment NA NA Rat Human +DTXSID0046808 Css NA 0.06794 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046808 Css NA 0.3989 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046808 Css NA 0.043 mg/L PBTK NA 50% Rat Human +DTXSID0046808 Css NA 0.2436 mg/L PBTK NA 95% Rat Human +DTXSID0046850 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046850 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046850 Vd NA 2.775 L/kg 1compartment NA NA Human Human DTXSID0046850 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046850 TK.Half.Life NA 2.198 hours 1compartment NA NA Human Human -DTXSID0046850 Css NA 0.0246 mg/L 3compartmentss NA 50% Human Human -DTXSID0046850 Css NA 0.2337 mg/L 3compartmentss NA 95% Human Human -DTXSID0046850 Css NA 0.0279 mg/L PBTK NA 50% Human Human -DTXSID0046850 Css NA 0.2018 mg/L PBTK NA 95% Human Human -DTXSID0046850 Clint NA 27.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046850 Fup NA 0.4274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046850 Vd NA 2.958 L/kg 1compartment NA NA Rat Human +DTXSID0046850 TK.Half.Life NA 5.488 hours 1compartment NA NA Human Human +DTXSID0046850 Css NA 0.1425 mg/L 3compartmentss NA 50% Human Human +DTXSID0046850 Css NA 0.9119 mg/L 3compartmentss NA 95% Human Human +DTXSID0046850 Css NA 0.1095 mg/L PBTK NA 50% Human Human +DTXSID0046850 Css NA 0.6606 mg/L PBTK NA 95% Human Human +DTXSID0046850 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046850 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046850 Vd NA 2.134 L/kg 1compartment NA NA Rat Human DTXSID0046850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046850 TK.Half.Life NA 1.17 hours 1compartment NA NA Rat Human -DTXSID0046850 Css NA 0.01262 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046850 Css NA 0.09588 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046850 Css NA 0.01438 mg/L PBTK NA 50% Rat Human -DTXSID0046850 Css NA 0.08167 mg/L PBTK NA 95% Rat Human -DTXSID0046852 Clint NA 15.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046852 Fup NA 0.0413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046852 Vd NA 0.8538 L/kg 1compartment NA NA Human Human +DTXSID0046850 TK.Half.Life NA 1.406 hours 1compartment NA NA Rat Human +DTXSID0046850 Css NA 0.01792 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046850 Css NA 0.0921 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046850 Css NA 0.01376 mg/L PBTK NA 50% Rat Human +DTXSID0046850 Css NA 0.06733 mg/L PBTK NA 95% Rat Human +DTXSID0046852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046852 Fup 0.0722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046852 Vd NA 0.93 L/kg 1compartment NA NA Human Human DTXSID0046852 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046852 TK.Half.Life NA 5.479 hours 1compartment NA NA Human Human -DTXSID0046852 Css NA 1.008 mg/L 3compartmentss NA 50% Human Human -DTXSID0046852 Css NA 8.897 mg/L 3compartmentss NA 95% Human Human -DTXSID0046852 Css NA 0.6188 mg/L PBTK NA 50% Human Human -DTXSID0046852 Css NA 5.282 mg/L PBTK NA 95% Human Human -DTXSID0046852 Clint NA 15.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046852 Fup NA 0.0413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046852 Vd NA 0.6541 L/kg 1compartment NA NA Rat Human +DTXSID0046852 TK.Half.Life NA 3.059 hours 1compartment NA NA Human Human +DTXSID0046852 Css NA 0.4018 mg/L 3compartmentss NA 50% Human Human +DTXSID0046852 Css NA 3.095 mg/L 3compartmentss NA 95% Human Human +DTXSID0046852 Css NA 0.2538 mg/L PBTK NA 50% Human Human +DTXSID0046852 Css NA 1.865 mg/L PBTK NA 95% Human Human +DTXSID0046852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046852 Fup 0.0722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046852 Vd NA 0.7244 L/kg 1compartment NA NA Rat Human DTXSID0046852 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046852 TK.Half.Life NA 2.505 hours 1compartment NA NA Rat Human -DTXSID0046852 Css NA 0.5722 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046852 Css NA 3.759 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046852 Css NA 0.3302 mg/L PBTK NA 50% Rat Human -DTXSID0046852 Css NA 2.086 mg/L PBTK NA 95% Rat Human -DTXSID0046856 Clint NA 26.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046856 Fup NA 0.2015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046856 Vd NA 3.696 L/kg 1compartment NA NA Human Human +DTXSID0046852 TK.Half.Life NA 1.362 hours 1compartment NA NA Rat Human +DTXSID0046852 Css NA 0.05252 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046852 Css NA 0.3097 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046852 Css NA 0.03238 mg/L PBTK NA 50% Rat Human +DTXSID0046852 Css NA 0.1842 mg/L PBTK NA 95% Rat Human +DTXSID0046856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046856 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046856 Vd NA 1.375 L/kg 1compartment NA NA Human Human DTXSID0046856 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046856 TK.Half.Life NA 3.464 hours 1compartment NA NA Human Human -DTXSID0046856 Css NA 0.03768 mg/L 3compartmentss NA 50% Human Human -DTXSID0046856 Css NA 0.2957 mg/L 3compartmentss NA 95% Human Human -DTXSID0046856 Css NA 0.04424 mg/L PBTK NA 50% Human Human -DTXSID0046856 Css NA 0.282 mg/L PBTK NA 95% Human Human -DTXSID0046856 Clint NA 26.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046856 Fup NA 0.2015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046856 Vd NA 3.72 L/kg 1compartment NA NA Rat Human +DTXSID0046856 TK.Half.Life NA 2.564 hours 1compartment NA NA Human Human +DTXSID0046856 Css NA 0.07797 mg/L 3compartmentss NA 50% Human Human +DTXSID0046856 Css NA 0.8005 mg/L 3compartmentss NA 95% Human Human +DTXSID0046856 Css NA 0.06065 mg/L PBTK NA 50% Human Human +DTXSID0046856 Css NA 0.5315 mg/L PBTK NA 95% Human Human +DTXSID0046856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046856 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046856 Vd NA 1.347 L/kg 1compartment NA NA Rat Human DTXSID0046856 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046856 TK.Half.Life NA 1.923 hours 1compartment NA NA Rat Human -DTXSID0046856 Css NA 0.0197 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046856 Css NA 0.1337 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046856 Css NA 0.02353 mg/L PBTK NA 50% Rat Human -DTXSID0046856 Css NA 0.1223 mg/L PBTK NA 95% Rat Human -DTXSID0046858 Clint NA 174.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046858 Fup NA 0.2387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046858 Vd NA 13.66 L/kg 1compartment NA NA Human Human -DTXSID0046858 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID0046858 TK.Half.Life NA 54.49 hours 1compartment NA NA Human Human -DTXSID0046858 Css NA 0.196 mg/L 3compartmentss NA 50% Human Human -DTXSID0046858 Css NA 1.196 mg/L 3compartmentss NA 95% Human Human -DTXSID0046858 Css NA 0.2979 mg/L PBTK NA 50% Human Human -DTXSID0046858 Css NA 1.716 mg/L PBTK NA 95% Human Human -DTXSID0046858 Clint NA 174.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046858 Fup NA 0.2387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046858 Vd NA 10.9 L/kg 1compartment NA NA Rat Human -DTXSID0046858 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID0046858 TK.Half.Life NA 8.357 hours 1compartment NA NA Rat Human -DTXSID0046858 Css NA 0.1051 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046858 Css NA 0.4638 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046858 Css NA 0.161 mg/L PBTK NA 50% Rat Human -DTXSID0046858 Css NA 0.7074 mg/L PBTK NA 95% Rat Human -DTXSID0046989 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046989 Fup NA 0.9876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0046989 Vd NA 0.771 L/kg 1compartment NA NA Human Human +DTXSID0046856 TK.Half.Life NA 1.48 hours 1compartment NA NA Rat Human +DTXSID0046856 Css NA 0.0007822 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046856 Css NA 0.007665 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046856 Css NA 0.000578 mg/L PBTK NA 50% Rat Human +DTXSID0046856 Css NA 0.004889 mg/L PBTK NA 95% Rat Human +DTXSID0046858 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046858 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046858 Vd NA 0.8418 L/kg 1compartment NA NA Human Human +DTXSID0046858 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0046858 TK.Half.Life NA 4.643 hours 1compartment NA NA Human Human +DTXSID0046858 Css NA 0.3923 mg/L 3compartmentss NA 50% Human Human +DTXSID0046858 Css NA 3.051 mg/L 3compartmentss NA 95% Human Human +DTXSID0046858 Css NA 0.2554 mg/L PBTK NA 50% Human Human +DTXSID0046858 Css NA 1.86 mg/L PBTK NA 95% Human Human +DTXSID0046858 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046858 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046858 Vd NA 0.6857 L/kg 1compartment NA NA Rat Human +DTXSID0046858 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0046858 TK.Half.Life NA 2.176 hours 1compartment NA NA Rat Human +DTXSID0046858 Css NA 0.003978 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046858 Css NA 0.02485 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046858 Css NA 0.00247 mg/L PBTK NA 50% Rat Human +DTXSID0046858 Css NA 0.01433 mg/L PBTK NA 95% Rat Human +DTXSID00469037 Clint 5.351 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00469037 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00469037 Vd NA 1.017 L/kg 1compartment NA NA Human Human +DTXSID00469037 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00469037 TK.Half.Life NA 2.189 hours 1compartment NA NA Human Human +DTXSID00469037 Css NA 0.1729 mg/L 3compartmentss NA 50% Human Human +DTXSID00469037 Css NA 1.143 mg/L 3compartmentss NA 95% Human Human +DTXSID00469037 Css NA 0.1354 mg/L PBTK NA 50% Human Human +DTXSID00469037 Css NA 0.7905 mg/L PBTK NA 95% Human Human +DTXSID00469037 Clint 5.351 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00469037 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00469037 Vd NA 0.8962 L/kg 1compartment NA NA Rat Human +DTXSID00469037 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00469037 TK.Half.Life NA 1.037 hours 1compartment NA NA Rat Human +DTXSID00469037 Css NA 0.01981 mg/L 3compartmentss NA 50% Rat Human +DTXSID00469037 Css NA 0.1004 mg/L 3compartmentss NA 95% Rat Human +DTXSID00469037 Css NA 0.0155 mg/L PBTK NA 50% Rat Human +DTXSID00469037 Css NA 0.06637 mg/L PBTK NA 95% Rat Human +DTXSID00469774 Clint 8.51 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00469774 Fup 0.0683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00469774 Vd NA 0.7982 L/kg 1compartment NA NA Human Human +DTXSID00469774 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00469774 TK.Half.Life NA 5.613 hours 1compartment NA NA Human Human +DTXSID00469774 Css NA 0.8354 mg/L 3compartmentss NA 50% Human Human +DTXSID00469774 Css NA 5.2 mg/L 3compartmentss NA 95% Human Human +DTXSID00469774 Css NA 0.5254 mg/L PBTK NA 50% Human Human +DTXSID00469774 Css NA 3.141 mg/L PBTK NA 95% Human Human +DTXSID00469774 Clint 8.51 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00469774 Fup 0.0683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00469774 Vd NA 0.6289 L/kg 1compartment NA NA Rat Human +DTXSID00469774 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00469774 TK.Half.Life NA 2.619 hours 1compartment NA NA Rat Human +DTXSID00469774 Css NA 0.03937 mg/L 3compartmentss NA 50% Rat Human +DTXSID00469774 Css NA 0.2703 mg/L 3compartmentss NA 95% Rat Human +DTXSID00469774 Css NA 0.0238 mg/L PBTK NA 50% Rat Human +DTXSID00469774 Css NA 0.1585 mg/L PBTK NA 95% Rat Human +DTXSID0046989 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046989 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0046989 Vd NA 0.4046 L/kg 1compartment NA NA Human Human DTXSID0046989 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0046989 TK.Half.Life NA 5.056 hours 1compartment NA NA Human Human -DTXSID0046989 Css NA 0.8635 mg/L 3compartmentss NA 50% Human Human -DTXSID0046989 Css NA 4.772 mg/L 3compartmentss NA 95% Human Human -DTXSID0046989 Css NA 0.7218 mg/L PBTK NA 50% Human Human -DTXSID0046989 Css NA 3.163 mg/L PBTK NA 95% Human Human -DTXSID0046989 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046989 Fup NA 0.9876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0046989 Vd NA 0.8074 L/kg 1compartment NA NA Rat Human +DTXSID0046989 TK.Half.Life NA 8.029 hours 1compartment NA NA Human Human +DTXSID0046989 Css NA 2.274 mg/L 3compartmentss NA 50% Human Human +DTXSID0046989 Css NA 8.991 mg/L 3compartmentss NA 95% Human Human +DTXSID0046989 Css NA 1.577 mg/L PBTK NA 50% Human Human +DTXSID0046989 Css NA 5.611 mg/L PBTK NA 95% Human Human +DTXSID0046989 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046989 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0046989 Vd NA 0.4234 L/kg 1compartment NA NA Rat Human DTXSID0046989 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0046989 TK.Half.Life NA 1.803 hours 1compartment NA NA Rat Human -DTXSID0046989 Css NA 0.2221 mg/L 3compartmentss NA 50% Rat Human -DTXSID0046989 Css NA 1.192 mg/L 3compartmentss NA 95% Rat Human -DTXSID0046989 Css NA 0.1805 mg/L PBTK NA 50% Rat Human -DTXSID0046989 Css NA 0.7247 mg/L PBTK NA 95% Rat Human +DTXSID0046989 TK.Half.Life NA 2.863 hours 1compartment NA NA Rat Human +DTXSID0046989 Css NA 0.1479 mg/L 3compartmentss NA 50% Rat Human +DTXSID0046989 Css NA 0.4984 mg/L 3compartmentss NA 95% Rat Human +DTXSID0046989 Css NA 0.1002 mg/L PBTK NA 50% Rat Human +DTXSID0046989 Css NA 0.2987 mg/L PBTK NA 95% Rat Human DTXSID0047030 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0047030 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0047030 Vd NA 0.4375 L/kg 1compartment NA NA Human Human DTXSID0047030 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0047030 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID0047030 Css NA 1.56 mg/L 3compartmentss NA 50% Human Human -DTXSID0047030 Css NA 7.454 mg/L 3compartmentss NA 95% Human Human -DTXSID0047030 Css NA 1.134 mg/L PBTK NA 50% Human Human -DTXSID0047030 Css NA 4.649 mg/L PBTK NA 95% Human Human +DTXSID0047030 Css NA 1.316 mg/L 3compartmentss NA 50% Human Human +DTXSID0047030 Css NA 6.429 mg/L 3compartmentss NA 95% Human Human +DTXSID0047030 Css NA 0.9592 mg/L PBTK NA 50% Human Human +DTXSID0047030 Css NA 4.025 mg/L PBTK NA 95% Human Human DTXSID0047030 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0047030 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0047030 Vd NA 0.4563 L/kg 1compartment NA NA Rat Human DTXSID0047030 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0047030 TK.Half.Life NA 2.08 hours 1compartment NA NA Rat Human -DTXSID0047030 Css NA 0.4248 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047030 Css NA 1.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047030 Css NA 0.2941 mg/L PBTK NA 50% Rat Human -DTXSID0047030 Css NA 1.038 mg/L PBTK NA 95% Rat Human -DTXSID0047036 Clint NA 17.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047036 Fup NA 0.6099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047036 Vd NA 3.372 L/kg 1compartment NA NA Human Human -DTXSID0047036 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047036 TK.Half.Life NA 2.425 hours 1compartment NA NA Human Human -DTXSID0047036 Css NA 0.02786 mg/L 3compartmentss NA 50% Human Human -DTXSID0047036 Css NA 0.3567 mg/L 3compartmentss NA 95% Human Human -DTXSID0047036 Css NA 0.03433 mg/L PBTK NA 50% Human Human -DTXSID0047036 Css NA 0.2835 mg/L PBTK NA 95% Human Human -DTXSID0047036 Clint NA 17.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047036 Fup NA 0.6099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047036 Vd NA 3.428 L/kg 1compartment NA NA Rat Human +DTXSID0047030 Css NA 0.02458 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047030 Css NA 0.1644 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047030 Css NA 0.01723 mg/L PBTK NA 50% Rat Human +DTXSID0047030 Css NA 0.1023 mg/L PBTK NA 95% Rat Human +DTXSID0047034 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047034 Fup 0.0542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047034 Vd NA 2.958 L/kg 1compartment NA NA Human Human +DTXSID0047034 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID0047034 TK.Half.Life NA 35.99 hours 1compartment NA NA Human Human +DTXSID0047034 Css NA 1.458 mg/L 3compartmentss NA 50% Human Human +DTXSID0047034 Css NA 9.392 mg/L 3compartmentss NA 95% Human Human +DTXSID0047034 Css NA 1.008 mg/L PBTK NA 50% Human Human +DTXSID0047034 Css NA 6.273 mg/L PBTK NA 95% Human Human +DTXSID0047034 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047034 Fup 0.0542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047034 Vd NA 2.218 L/kg 1compartment NA NA Rat Human +DTXSID0047034 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0047034 TK.Half.Life NA 6.194 hours 1compartment NA NA Rat Human +DTXSID0047034 Css NA 0.1868 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047034 Css NA 1.018 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047034 Css NA 0.1274 mg/L PBTK NA 50% Rat Human +DTXSID0047034 Css NA 0.6871 mg/L PBTK NA 95% Rat Human +DTXSID0047036 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047036 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047036 Vd NA 0.99 L/kg 1compartment NA NA Human Human +DTXSID0047036 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0047036 TK.Half.Life NA 13.98 hours 1compartment NA NA Human Human +DTXSID0047036 Css NA 1.215 mg/L 3compartmentss NA 50% Human Human +DTXSID0047036 Css NA 6.146 mg/L 3compartmentss NA 95% Human Human +DTXSID0047036 Css NA 1.003 mg/L PBTK NA 50% Human Human +DTXSID0047036 Css NA 4.076 mg/L PBTK NA 95% Human Human +DTXSID0047036 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047036 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047036 Vd NA 1.014 L/kg 1compartment NA NA Rat Human DTXSID0047036 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047036 TK.Half.Life NA 1.316 hours 1compartment NA NA Rat Human -DTXSID0047036 Css NA 0.01376 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047036 Css NA 0.1573 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047036 Css NA 0.01692 mg/L PBTK NA 50% Rat Human -DTXSID0047036 Css NA 0.121 mg/L PBTK NA 95% Rat Human -DTXSID0047038 Clint NA 10.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047038 Fup NA 0.296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047038 Vd NA 1.465 L/kg 1compartment NA NA Human Human +DTXSID0047036 TK.Half.Life NA 4.881 hours 1compartment NA NA Rat Human +DTXSID0047036 Css NA 0.02222 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047036 Css NA 0.1634 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047036 Css NA 0.01777 mg/L PBTK NA 50% Rat Human +DTXSID0047036 Css NA 0.1101 mg/L PBTK NA 95% Rat Human +DTXSID0047038 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047038 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047038 Vd NA 1.245 L/kg 1compartment NA NA Human Human DTXSID0047038 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047038 TK.Half.Life NA 2.93 hours 1compartment NA NA Human Human -DTXSID0047038 Css NA 0.1564 mg/L 3compartmentss NA 50% Human Human -DTXSID0047038 Css NA 1.014 mg/L 3compartmentss NA 95% Human Human -DTXSID0047038 Css NA 0.1187 mg/L PBTK NA 50% Human Human -DTXSID0047038 Css NA 0.705 mg/L PBTK NA 95% Human Human -DTXSID0047038 Clint NA 10.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047038 Fup NA 0.296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047038 Vd NA 1.187 L/kg 1compartment NA NA Rat Human +DTXSID0047038 TK.Half.Life NA 1.878 hours 1compartment NA NA Human Human +DTXSID0047038 Css NA 0.09272 mg/L 3compartmentss NA 50% Human Human +DTXSID0047038 Css NA 0.6353 mg/L 3compartmentss NA 95% Human Human +DTXSID0047038 Css NA 0.06706 mg/L PBTK NA 50% Human Human +DTXSID0047038 Css NA 0.4326 mg/L PBTK NA 95% Human Human +DTXSID0047038 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047038 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047038 Vd NA 1.015 L/kg 1compartment NA NA Rat Human DTXSID0047038 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047038 TK.Half.Life NA 1.199 hours 1compartment NA NA Rat Human -DTXSID0047038 Css NA 0.08314 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047038 Css NA 0.3913 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047038 Css NA 0.06042 mg/L PBTK NA 50% Rat Human -DTXSID0047038 Css NA 0.2579 mg/L PBTK NA 95% Rat Human -DTXSID0047084 Clint NA 1.067 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047084 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047084 Vd NA 1.32 L/kg 1compartment NA NA Human Human +DTXSID0047038 TK.Half.Life NA 0.7834 hours 1compartment NA NA Rat Human +DTXSID0047038 Css NA 0.01142 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047038 Css NA 0.06099 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047038 Css NA 0.008258 mg/L PBTK NA 50% Rat Human +DTXSID0047038 Css NA 0.04088 mg/L PBTK NA 95% Rat Human +DTXSID0047080 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047080 Fup 0.186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047080 Vd NA 1.192 L/kg 1compartment NA NA Human Human +DTXSID0047080 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047080 TK.Half.Life NA 2.122 hours 1compartment NA NA Human Human +DTXSID0047080 Css NA 0.123 mg/L 3compartmentss NA 50% Human Human +DTXSID0047080 Css NA 0.8434 mg/L 3compartmentss NA 95% Human Human +DTXSID0047080 Css NA 0.08699 mg/L PBTK NA 50% Human Human +DTXSID0047080 Css NA 0.5624 mg/L PBTK NA 95% Human Human +DTXSID0047080 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047080 Fup 0.186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047080 Vd NA 0.9578 L/kg 1compartment NA NA Rat Human +DTXSID0047080 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0047080 TK.Half.Life NA 0.8915 hours 1compartment NA NA Rat Human +DTXSID0047080 Css NA 0.01557 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047080 Css NA 0.08305 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047080 Css NA 0.0108 mg/L PBTK NA 50% Rat Human +DTXSID0047080 Css NA 0.05481 mg/L PBTK NA 95% Rat Human +DTXSID0047082 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047082 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047082 Vd NA 1.539 L/kg 1compartment NA NA Human Human +DTXSID0047082 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047082 TK.Half.Life NA 1.78 hours 1compartment NA NA Human Human +DTXSID0047082 Css NA 0.05341 mg/L 3compartmentss NA 50% Human Human +DTXSID0047082 Css NA 0.4373 mg/L 3compartmentss NA 95% Human Human +DTXSID0047082 Css NA 0.04271 mg/L PBTK NA 50% Human Human +DTXSID0047082 Css NA 0.3118 mg/L PBTK NA 95% Human Human +DTXSID0047082 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047082 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047082 Vd NA 1.27 L/kg 1compartment NA NA Rat Human +DTXSID0047082 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0047082 TK.Half.Life NA 0.7093 hours 1compartment NA NA Rat Human +DTXSID0047082 Css NA 0.006615 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047082 Css NA 0.04016 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047082 Css NA 0.005334 mg/L PBTK NA 50% Rat Human +DTXSID0047082 Css NA 0.02879 mg/L PBTK NA 95% Rat Human +DTXSID0047084 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047084 Fup 0.576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047084 Vd NA 0.9469 L/kg 1compartment NA NA Human Human DTXSID0047084 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047084 TK.Half.Life NA 3.524 hours 1compartment NA NA Human Human -DTXSID0047084 Css NA 0.2758 mg/L 3compartmentss NA 50% Human Human -DTXSID0047084 Css NA 2.051 mg/L 3compartmentss NA 95% Human Human -DTXSID0047084 Css NA 0.2568 mg/L PBTK NA 50% Human Human -DTXSID0047084 Css NA 1.398 mg/L PBTK NA 95% Human Human -DTXSID0047084 Clint NA 1.067 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047084 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047084 Vd NA 1.248 L/kg 1compartment NA NA Rat Human +DTXSID0047084 TK.Half.Life NA 0.8614 hours 1compartment NA NA Human Human +DTXSID0047084 Css NA 0.02669 mg/L 3compartmentss NA 50% Human Human +DTXSID0047084 Css NA 0.3351 mg/L 3compartmentss NA 95% Human Human +DTXSID0047084 Css NA 0.02206 mg/L PBTK NA 50% Human Human +DTXSID0047084 Css NA 0.2329 mg/L PBTK NA 95% Human Human +DTXSID0047084 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047084 Fup 0.576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047084 Vd NA 0.8912 L/kg 1compartment NA NA Rat Human DTXSID0047084 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047084 TK.Half.Life NA 1.553 hours 1compartment NA NA Rat Human -DTXSID0047084 Css NA 0.1028 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047084 Css NA 0.7053 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047084 Css NA 0.09569 mg/L PBTK NA 50% Rat Human -DTXSID0047084 Css NA 0.4432 mg/L PBTK NA 95% Rat Human -DTXSID0047111 Clint NA 46.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047111 Fup NA 0.0354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047111 Vd NA 2.977 L/kg 1compartment NA NA Human Human -DTXSID0047111 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0047111 TK.Half.Life NA 23.12 hours 1compartment NA NA Human Human -DTXSID0047111 Css NA 0.9096 mg/L 3compartmentss NA 50% Human Human -DTXSID0047111 Css NA 5.776 mg/L 3compartmentss NA 95% Human Human -DTXSID0047111 Css NA 0.6277 mg/L PBTK NA 50% Human Human -DTXSID0047111 Css NA 3.849 mg/L PBTK NA 95% Human Human -DTXSID0047111 Clint NA 46.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047111 Fup NA 0.0354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047111 Vd NA 2.23 L/kg 1compartment NA NA Rat Human -DTXSID0047111 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0047111 TK.Half.Life NA 4.051 hours 1compartment NA NA Rat Human -DTXSID0047111 Css NA 0.5069 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047111 Css NA 2.631 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047111 Css NA 0.3336 mg/L PBTK NA 50% Rat Human -DTXSID0047111 Css NA 1.663 mg/L PBTK NA 95% Rat Human -DTXSID0047115 Clint NA 1.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047115 Fup NA 0.1314 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047115 Vd NA 0.4535 L/kg 1compartment NA NA Human Human -DTXSID0047115 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047115 TK.Half.Life NA 6.167 hours 1compartment NA NA Human Human -DTXSID0047115 Css NA 1.955 mg/L 3compartmentss NA 50% Human Human -DTXSID0047115 Css NA 10.82 mg/L 3compartmentss NA 95% Human Human -DTXSID0047115 Css NA 1.282 mg/L PBTK NA 50% Human Human -DTXSID0047115 Css NA 6.529 mg/L PBTK NA 95% Human Human -DTXSID0047115 Clint NA 1.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047115 Fup NA 0.1314 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047115 Vd NA 0.4177 L/kg 1compartment NA NA Rat Human +DTXSID0047084 TK.Half.Life NA 0.4021 hours 1compartment NA NA Rat Human +DTXSID0047084 Css NA 0.000985 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047084 Css NA 0.0127 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047084 Css NA 0.000801 mg/L PBTK NA 50% Rat Human +DTXSID0047084 Css NA 0.008317 mg/L PBTK NA 95% Rat Human +DTXSID0047111 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047111 Fup 0.0254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047111 Vd NA 3.008 L/kg 1compartment NA NA Human Human +DTXSID0047111 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID0047111 TK.Half.Life NA 57.19 hours 1compartment NA NA Human Human +DTXSID0047111 Css NA 2.329 mg/L 3compartmentss NA 50% Human Human +DTXSID0047111 Css NA 15.86 mg/L 3compartmentss NA 95% Human Human +DTXSID0047111 Css NA 1.594 mg/L PBTK NA 50% Human Human +DTXSID0047111 Css NA 10.49 mg/L PBTK NA 95% Human Human +DTXSID0047111 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047111 Fup 0.0254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047111 Vd NA 2.253 L/kg 1compartment NA NA Rat Human +DTXSID0047111 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0047111 TK.Half.Life NA 9.043 hours 1compartment NA NA Rat Human +DTXSID0047111 Css NA 0.3048 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047111 Css NA 1.664 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047111 Css NA 0.2072 mg/L PBTK NA 50% Rat Human +DTXSID0047111 Css NA 1.097 mg/L PBTK NA 95% Rat Human +DTXSID0047115 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047115 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047115 Vd NA 0.4354 L/kg 1compartment NA NA Human Human +DTXSID0047115 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0047115 TK.Half.Life NA 11.63 hours 1compartment NA NA Human Human +DTXSID0047115 Css NA 3.048 mg/L 3compartmentss NA 50% Human Human +DTXSID0047115 Css NA 11.7 mg/L 3compartmentss NA 95% Human Human +DTXSID0047115 Css NA 2.106 mg/L PBTK NA 50% Human Human +DTXSID0047115 Css NA 7.19 mg/L PBTK NA 95% Human Human +DTXSID0047115 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047115 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047115 Vd NA 0.4237 L/kg 1compartment NA NA Rat Human DTXSID0047115 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047115 TK.Half.Life NA 3.037 hours 1compartment NA NA Rat Human -DTXSID0047115 Css NA 0.875 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047115 Css NA 3.957 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047115 Css NA 0.5389 mg/L PBTK NA 50% Rat Human -DTXSID0047115 Css NA 2.235 mg/L PBTK NA 95% Rat Human -DTXSID0047117 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047117 Fup NA 0.3952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047117 Vd NA 2.924 L/kg 1compartment NA NA Human Human -DTXSID0047117 Days.Css NA 70 Days PBTK NA NA Human Human -DTXSID0047117 TK.Half.Life NA 317.2 hours 1compartment NA NA Human Human -DTXSID0047117 Css NA 11.76 mg/L 3compartmentss NA 50% Human Human -DTXSID0047117 Css NA 33.77 mg/L 3compartmentss NA 95% Human Human -DTXSID0047117 Css NA 8.792 mg/L PBTK NA 50% Human Human -DTXSID0047117 Css NA 22.92 mg/L PBTK NA 95% Human Human -DTXSID0047117 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047117 Fup NA 0.3952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047117 Vd NA 2.227 L/kg 1compartment NA NA Rat Human -DTXSID0047117 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID0047117 TK.Half.Life NA 29.09 hours 1compartment NA NA Rat Human -DTXSID0047117 Css NA 3.158 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047117 Css NA 7.337 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047117 Css NA 2.27 mg/L PBTK NA 50% Rat Human -DTXSID0047117 Css NA 4.608 mg/L PBTK NA 95% Rat Human -DTXSID0047161 Clint NA 40.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047161 Fup NA 0.4136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047161 Vd NA 1.714 L/kg 1compartment NA NA Human Human +DTXSID0047115 TK.Half.Life NA 3.847 hours 1compartment NA NA Rat Human +DTXSID0047115 Css NA 0.1978 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047115 Css NA 0.629 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047115 Css NA 0.134 mg/L PBTK NA 50% Rat Human +DTXSID0047115 Css NA 0.3783 mg/L PBTK NA 95% Rat Human +DTXSID0047161 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047161 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047161 Vd NA 1.266 L/kg 1compartment NA NA Human Human DTXSID0047161 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047161 TK.Half.Life NA 1.62 hours 1compartment NA NA Human Human -DTXSID0047161 Css NA 0.03223 mg/L 3compartmentss NA 50% Human Human -DTXSID0047161 Css NA 0.2485 mg/L 3compartmentss NA 95% Human Human -DTXSID0047161 Css NA 0.02601 mg/L PBTK NA 50% Human Human -DTXSID0047161 Css NA 0.176 mg/L PBTK NA 95% Human Human -DTXSID0047161 Clint NA 40.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047161 Fup NA 0.4136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047161 Vd NA 1.396 L/kg 1compartment NA NA Rat Human +DTXSID0047161 TK.Half.Life NA 2.158 hours 1compartment NA NA Human Human +DTXSID0047161 Css NA 0.1139 mg/L 3compartmentss NA 50% Human Human +DTXSID0047161 Css NA 0.785 mg/L 3compartmentss NA 95% Human Human +DTXSID0047161 Css NA 0.08104 mg/L PBTK NA 50% Human Human +DTXSID0047161 Css NA 0.5262 mg/L PBTK NA 95% Human Human +DTXSID0047161 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047161 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047161 Vd NA 1.016 L/kg 1compartment NA NA Rat Human DTXSID0047161 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047161 TK.Half.Life NA 0.6054 hours 1compartment NA NA Rat Human -DTXSID0047161 Css NA 0.0176 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047161 Css NA 0.1065 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047161 Css NA 0.01375 mg/L PBTK NA 50% Rat Human -DTXSID0047161 Css NA 0.07442 mg/L PBTK NA 95% Rat Human -DTXSID0047165 Clint NA 25.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047165 Fup NA 0.5516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047165 Vd NA 1.366 L/kg 1compartment NA NA Human Human +DTXSID0047161 TK.Half.Life NA 0.8929 hours 1compartment NA NA Rat Human +DTXSID0047161 Css NA 0.01434 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047161 Css NA 0.07638 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047161 Css NA 0.01011 mg/L PBTK NA 50% Rat Human +DTXSID0047161 Css NA 0.0508 mg/L PBTK NA 95% Rat Human +DTXSID0047163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047163 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047163 Vd NA 1.925 L/kg 1compartment NA NA Human Human +DTXSID0047163 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047163 TK.Half.Life NA 5.613 hours 1compartment NA NA Human Human +DTXSID0047163 Css NA 0.3026 mg/L 3compartmentss NA 50% Human Human +DTXSID0047163 Css NA 2.225 mg/L 3compartmentss NA 95% Human Human +DTXSID0047163 Css NA 0.2059 mg/L PBTK NA 50% Human Human +DTXSID0047163 Css NA 1.428 mg/L PBTK NA 95% Human Human +DTXSID0047163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047163 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047163 Vd NA 1.464 L/kg 1compartment NA NA Rat Human +DTXSID0047163 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0047163 TK.Half.Life NA 1.921 hours 1compartment NA NA Rat Human +DTXSID0047163 Css NA 0.03917 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047163 Css NA 0.2226 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047163 Css NA 0.02618 mg/L PBTK NA 50% Rat Human +DTXSID0047163 Css NA 0.1424 mg/L PBTK NA 95% Rat Human +DTXSID0047165 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047165 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047165 Vd NA 1.143 L/kg 1compartment NA NA Human Human DTXSID0047165 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047165 TK.Half.Life NA 1.22 hours 1compartment NA NA Human Human -DTXSID0047165 Css NA 0.03277 mg/L 3compartmentss NA 50% Human Human -DTXSID0047165 Css NA 0.3265 mg/L 3compartmentss NA 95% Human Human -DTXSID0047165 Css NA 0.02782 mg/L PBTK NA 50% Human Human -DTXSID0047165 Css NA 0.2281 mg/L PBTK NA 95% Human Human -DTXSID0047165 Clint NA 25.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047165 Fup NA 0.5516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047165 Vd NA 1.187 L/kg 1compartment NA NA Rat Human +DTXSID0047165 TK.Half.Life NA 1.767 hours 1compartment NA NA Human Human +DTXSID0047165 Css NA 0.09597 mg/L 3compartmentss NA 50% Human Human +DTXSID0047165 Css NA 0.6783 mg/L 3compartmentss NA 95% Human Human +DTXSID0047165 Css NA 0.06886 mg/L PBTK NA 50% Human Human +DTXSID0047165 Css NA 0.4603 mg/L PBTK NA 95% Human Human +DTXSID0047165 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047165 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047165 Vd NA 0.9381 L/kg 1compartment NA NA Rat Human DTXSID0047165 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047165 TK.Half.Life NA 0.5093 hours 1compartment NA NA Rat Human -DTXSID0047165 Css NA 0.01757 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047165 Css NA 0.1447 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047165 Css NA 0.01437 mg/L PBTK NA 50% Rat Human -DTXSID0047165 Css NA 0.09652 mg/L PBTK NA 95% Rat Human +DTXSID0047165 TK.Half.Life NA 0.754 hours 1compartment NA NA Rat Human +DTXSID0047165 Css NA 0.01189 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047165 Css NA 0.06649 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047165 Css NA 0.0085 mg/L PBTK NA 50% Rat Human +DTXSID0047165 Css NA 0.04441 mg/L PBTK NA 95% Rat Human DTXSID0047167 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0047167 Fup NA 0.8944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0047167 Vd NA 0.7168 L/kg 1compartment NA NA Human Human DTXSID0047167 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0047167 TK.Half.Life NA 5.188 hours 1compartment NA NA Human Human -DTXSID0047167 Css NA 0.9006 mg/L 3compartmentss NA 50% Human Human -DTXSID0047167 Css NA 3.575 mg/L 3compartmentss NA 95% Human Human -DTXSID0047167 Css NA 0.7399 mg/L PBTK NA 50% Human Human -DTXSID0047167 Css NA 2.455 mg/L PBTK NA 95% Human Human +DTXSID0047167 Css NA 0.7664 mg/L 3compartmentss NA 50% Human Human +DTXSID0047167 Css NA 3.028 mg/L 3compartmentss NA 95% Human Human +DTXSID0047167 Css NA 0.6297 mg/L PBTK NA 50% Human Human +DTXSID0047167 Css NA 2.086 mg/L PBTK NA 95% Human Human DTXSID0047167 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0047167 Fup NA 0.8944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0047167 Vd NA 0.7505 L/kg 1compartment NA NA Rat Human DTXSID0047167 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0047167 TK.Half.Life NA 1.85 hours 1compartment NA NA Rat Human -DTXSID0047167 Css NA 0.2321 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047167 Css NA 0.8384 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047167 Css NA 0.186 mg/L PBTK NA 50% Rat Human -DTXSID0047167 Css NA 0.5296 mg/L PBTK NA 95% Rat Human -DTXSID0047242 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047242 Fup NA 0.9008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047242 Vd NA 1.015 L/kg 1compartment NA NA Human Human -DTXSID0047242 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047242 TK.Half.Life NA 0.6508 hours 1compartment NA NA Human Human -DTXSID0047242 Css NA 0.01392 mg/L 3compartmentss NA 50% Human Human -DTXSID0047242 Css NA 0.108 mg/L 3compartmentss NA 95% Human Human -DTXSID0047242 Css NA 0.01195 mg/L PBTK NA 50% Human Human -DTXSID0047242 Css NA 0.08267 mg/L PBTK NA 95% Human Human -DTXSID0047242 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047242 Fup NA 0.9008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047242 Vd NA 1.008 L/kg 1compartment NA NA Rat Human -DTXSID0047242 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047242 TK.Half.Life NA 0.2993 hours 1compartment NA NA Rat Human -DTXSID0047242 Css NA 0.007165 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047242 Css NA 0.04775 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047242 Css NA 0.006195 mg/L PBTK NA 50% Rat Human -DTXSID0047242 Css NA 0.03669 mg/L PBTK NA 95% Rat Human -DTXSID0047244 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047244 Fup NA 0.2609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047244 Vd NA 2.811 L/kg 1compartment NA NA Human Human -DTXSID0047244 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID0047244 TK.Half.Life NA 34.61 hours 1compartment NA NA Human Human -DTXSID0047244 Css NA 1.384 mg/L 3compartmentss NA 50% Human Human -DTXSID0047244 Css NA 6.774 mg/L 3compartmentss NA 95% Human Human -DTXSID0047244 Css NA 1.012 mg/L PBTK NA 50% Human Human -DTXSID0047244 Css NA 4.702 mg/L PBTK NA 95% Human Human -DTXSID0047244 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047244 Fup NA 0.2609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047244 Vd NA 2.135 L/kg 1compartment NA NA Rat Human -DTXSID0047244 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0047244 TK.Half.Life NA 6.684 hours 1compartment NA NA Rat Human -DTXSID0047244 Css NA 0.7036 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047244 Css NA 2.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047244 Css NA 0.4946 mg/L PBTK NA 50% Rat Human -DTXSID0047244 Css NA 1.562 mg/L PBTK NA 95% Rat Human +DTXSID0047167 Css NA 0.01382 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047167 Css NA 0.07823 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047167 Css NA 0.01094 mg/L PBTK NA 50% Rat Human +DTXSID0047167 Css NA 0.0551 mg/L PBTK NA 95% Rat Human +DTXSID0047169 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047169 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047169 Vd NA 0.7403 L/kg 1compartment NA NA Human Human +DTXSID0047169 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047169 TK.Half.Life NA 1.047 hours 1compartment NA NA Human Human +DTXSID0047169 Css NA 0.07884 mg/L 3compartmentss NA 50% Human Human +DTXSID0047169 Css NA 0.5822 mg/L 3compartmentss NA 95% Human Human +DTXSID0047169 Css NA 0.05591 mg/L PBTK NA 50% Human Human +DTXSID0047169 Css NA 0.3846 mg/L PBTK NA 95% Human Human +DTXSID0047169 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047169 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047169 Vd NA 0.6621 L/kg 1compartment NA NA Rat Human +DTXSID0047169 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0047169 TK.Half.Life NA 0.4994 hours 1compartment NA NA Rat Human +DTXSID0047169 Css NA 0.01014 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047169 Css NA 0.05567 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047169 Css NA 0.007088 mg/L PBTK NA 50% Rat Human +DTXSID0047169 Css NA 0.03637 mg/L PBTK NA 95% Rat Human DTXSID0047246 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0047246 Fup 0.00678 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0047246 Vd NA 0.2744 L/kg 1compartment NA NA Human Human -DTXSID0047246 Days.Css NA 64 Days PBTK NA NA Human Human -DTXSID0047246 TK.Half.Life NA 264 hours 1compartment NA NA Human Human -DTXSID0047246 Css NA 101.8 mg/L 3compartmentss NA 50% Human Human -DTXSID0047246 Css NA 451.4 mg/L 3compartmentss NA 95% Human Human -DTXSID0047246 Css NA 59.77 mg/L PBTK NA 50% Human Human -DTXSID0047246 Css NA 259.7 mg/L PBTK NA 95% Human Human +DTXSID0047246 Vd NA 0.1644 L/kg 1compartment NA NA Human Human +DTXSID0047246 Days.Css NA 36 Days PBTK NA NA Human Human +DTXSID0047246 TK.Half.Life NA 156.9 hours 1compartment NA NA Human Human +DTXSID0047246 Css NA 98.4 mg/L 3compartmentss NA 50% Human Human +DTXSID0047246 Css NA 442.9 mg/L 3compartmentss NA 95% Human Human +DTXSID0047246 Css NA 57.4 mg/L PBTK NA 50% Human Human +DTXSID0047246 Css NA 252.8 mg/L PBTK NA 95% Human Human DTXSID0047246 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0047246 Fup 0.00678 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0047246 Vd NA 0.2305 L/kg 1compartment NA NA Rat Human -DTXSID0047246 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID0047246 TK.Half.Life NA 75.11 hours 1compartment NA NA Rat Human -DTXSID0047246 Css NA 29.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047246 Css NA 102.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047246 Css NA 15.98 mg/L PBTK NA 50% Rat Human -DTXSID0047246 Css NA 55.78 mg/L PBTK NA 95% Rat Human -DTXSID0047248 Clint NA 21.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047248 Fup NA 0.0913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047248 Vd NA 0.7578 L/kg 1compartment NA NA Human Human +DTXSID0047246 Vd NA 0.1629 L/kg 1compartment NA NA Rat Human +DTXSID0047246 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID0047246 TK.Half.Life NA 52.99 hours 1compartment NA NA Rat Human +DTXSID0047246 Css NA 6.493 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047246 Css NA 23.54 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047246 Css NA 3.649 mg/L PBTK NA 50% Rat Human +DTXSID0047246 Css NA 13.18 mg/L PBTK NA 95% Rat Human +DTXSID0047248 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047248 Fup 0.065 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047248 Vd NA 1.603 L/kg 1compartment NA NA Human Human DTXSID0047248 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047248 TK.Half.Life NA 2.104 hours 1compartment NA NA Human Human -DTXSID0047248 Css NA 0.325 mg/L 3compartmentss NA 50% Human Human -DTXSID0047248 Css NA 2.58 mg/L 3compartmentss NA 95% Human Human -DTXSID0047248 Css NA 0.2056 mg/L PBTK NA 50% Human Human -DTXSID0047248 Css NA 1.573 mg/L PBTK NA 95% Human Human -DTXSID0047248 Clint NA 21.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047248 Fup NA 0.0913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047248 Vd NA 0.6045 L/kg 1compartment NA NA Rat Human +DTXSID0047248 TK.Half.Life NA 6.388 hours 1compartment NA NA Human Human +DTXSID0047248 Css NA 0.486 mg/L 3compartmentss NA 50% Human Human +DTXSID0047248 Css NA 3.294 mg/L 3compartmentss NA 95% Human Human +DTXSID0047248 Css NA 0.3152 mg/L PBTK NA 50% Human Human +DTXSID0047248 Css NA 2.07 mg/L PBTK NA 95% Human Human +DTXSID0047248 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047248 Fup 0.065 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047248 Vd NA 1.206 L/kg 1compartment NA NA Rat Human DTXSID0047248 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047248 TK.Half.Life NA 0.9661 hours 1compartment NA NA Rat Human -DTXSID0047248 Css NA 0.1817 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047248 Css NA 1.113 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047248 Css NA 0.1076 mg/L PBTK NA 50% Rat Human -DTXSID0047248 Css NA 0.6316 mg/L PBTK NA 95% Rat Human -DTXSID0047290 Clint NA 102.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047290 Fup NA 0.1936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047290 Vd NA 3.64 L/kg 1compartment NA NA Human Human +DTXSID0047248 TK.Half.Life NA 2.38 hours 1compartment NA NA Rat Human +DTXSID0047248 Css NA 0.06242 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047248 Css NA 0.3539 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047248 Css NA 0.03964 mg/L PBTK NA 50% Rat Human +DTXSID0047248 Css NA 0.2158 mg/L PBTK NA 95% Rat Human +DTXSID0047290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047290 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047290 Vd NA 2.47 L/kg 1compartment NA NA Human Human DTXSID0047290 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047290 TK.Half.Life NA 2.513 hours 1compartment NA NA Human Human -DTXSID0047290 Css NA 0.01507 mg/L 3compartmentss NA 50% Human Human -DTXSID0047290 Css NA 0.116 mg/L 3compartmentss NA 95% Human Human -DTXSID0047290 Css NA 0.01573 mg/L PBTK NA 50% Human Human -DTXSID0047290 Css NA 0.1017 mg/L PBTK NA 95% Human Human -DTXSID0047290 Clint NA 102.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047290 Fup NA 0.1936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047290 Vd NA 3.479 L/kg 1compartment NA NA Rat Human +DTXSID0047290 TK.Half.Life NA 10.91 hours 1compartment NA NA Human Human +DTXSID0047290 Css NA 0.4967 mg/L 3compartmentss NA 50% Human Human +DTXSID0047290 Css NA 3.331 mg/L 3compartmentss NA 95% Human Human +DTXSID0047290 Css NA 0.3397 mg/L PBTK NA 50% Human Human +DTXSID0047290 Css NA 2.197 mg/L PBTK NA 95% Human Human +DTXSID0047290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047290 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047290 Vd NA 1.861 L/kg 1compartment NA NA Rat Human DTXSID0047290 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047290 TK.Half.Life NA 1.114 hours 1compartment NA NA Rat Human -DTXSID0047290 Css NA 0.008064 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047290 Css NA 0.05118 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047290 Css NA 0.008439 mg/L PBTK NA 50% Rat Human -DTXSID0047290 Css NA 0.04511 mg/L PBTK NA 95% Rat Human -DTXSID0047294 Clint NA 16.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047294 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047294 Vd NA 0.9628 L/kg 1compartment NA NA Human Human +DTXSID0047290 TK.Half.Life NA 2.91 hours 1compartment NA NA Rat Human +DTXSID0047290 Css NA 0.0639 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047290 Css NA 0.347 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047290 Css NA 0.0433 mg/L PBTK NA 50% Rat Human +DTXSID0047290 Css NA 0.2283 mg/L PBTK NA 95% Rat Human +DTXSID0047292 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047292 Fup 0.554 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047292 Vd NA 1.958 L/kg 1compartment NA NA Human Human +DTXSID0047292 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID0047292 TK.Half.Life NA 34.8 hours 1compartment NA NA Human Human +DTXSID0047292 Css NA 1.769 mg/L 3compartmentss NA 50% Human Human +DTXSID0047292 Css NA 9.598 mg/L 3compartmentss NA 95% Human Human +DTXSID0047292 Css NA 1.494 mg/L PBTK NA 50% Human Human +DTXSID0047292 Css NA 6.405 mg/L PBTK NA 95% Human Human +DTXSID0047292 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047292 Fup 0.554 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047292 Vd NA 1.591 L/kg 1compartment NA NA Rat Human +DTXSID0047292 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0047292 TK.Half.Life NA 7.119 hours 1compartment NA NA Rat Human +DTXSID0047292 Css NA 0.1101 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047292 Css NA 0.5423 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047292 Css NA 0.09314 mg/L PBTK NA 50% Rat Human +DTXSID0047292 Css NA 0.3455 mg/L PBTK NA 95% Rat Human +DTXSID0047294 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047294 Fup 0.0959 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047294 Vd NA 0.5863 L/kg 1compartment NA NA Human Human DTXSID0047294 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047294 TK.Half.Life NA 5.454 hours 1compartment NA NA Human Human -DTXSID0047294 Css NA 0.8454 mg/L 3compartmentss NA 50% Human Human -DTXSID0047294 Css NA 6.376 mg/L 3compartmentss NA 95% Human Human -DTXSID0047294 Css NA 0.527 mg/L PBTK NA 50% Human Human -DTXSID0047294 Css NA 3.837 mg/L PBTK NA 95% Human Human -DTXSID0047294 Clint NA 16.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047294 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047294 Vd NA 0.7348 L/kg 1compartment NA NA Rat Human +DTXSID0047294 TK.Half.Life NA 3.885 hours 1compartment NA NA Human Human +DTXSID0047294 Css NA 0.9451 mg/L 3compartmentss NA 50% Human Human +DTXSID0047294 Css NA 6.756 mg/L 3compartmentss NA 95% Human Human +DTXSID0047294 Css NA 0.5985 mg/L PBTK NA 50% Human Human +DTXSID0047294 Css NA 4.089 mg/L PBTK NA 95% Human Human +DTXSID0047294 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047294 Fup 0.0959 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047294 Vd NA 0.4941 L/kg 1compartment NA NA Rat Human DTXSID0047294 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047294 TK.Half.Life NA 2.424 hours 1compartment NA NA Rat Human -DTXSID0047294 Css NA 0.4799 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047294 Css NA 2.632 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047294 Css NA 0.2788 mg/L PBTK NA 50% Rat Human -DTXSID0047294 Css NA 1.493 mg/L PBTK NA 95% Rat Human -DTXSID0047296 Clint NA 1.668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0047294 TK.Half.Life NA 1.96 hours 1compartment NA NA Rat Human +DTXSID0047294 Css NA 0.1175 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047294 Css NA 0.6107 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047294 Css NA 0.07187 mg/L PBTK NA 50% Rat Human +DTXSID0047294 Css NA 0.3535 mg/L PBTK NA 95% Rat Human +DTXSID0047296 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0047296 Fup 0.0091 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0047296 Vd NA 0.2032 L/kg 1compartment NA NA Human Human -DTXSID0047296 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID0047296 TK.Half.Life NA 38.49 hours 1compartment NA NA Human Human -DTXSID0047296 Css NA 21.44 mg/L 3compartmentss NA 50% Human Human -DTXSID0047296 Css NA 87.74 mg/L 3compartmentss NA 95% Human Human -DTXSID0047296 Css NA 12.7 mg/L PBTK NA 50% Human Human -DTXSID0047296 Css NA 51.18 mg/L PBTK NA 95% Human Human -DTXSID0047296 Clint NA 1.668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0047296 Vd NA 0.1988 L/kg 1compartment NA NA Human Human +DTXSID0047296 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0047296 TK.Half.Life NA 12.62 hours 1compartment NA NA Human Human +DTXSID0047296 Css NA 6.386 mg/L 3compartmentss NA 50% Human Human +DTXSID0047296 Css NA 36.52 mg/L 3compartmentss NA 95% Human Human +DTXSID0047296 Css NA 3.763 mg/L PBTK NA 50% Human Human +DTXSID0047296 Css NA 21.27 mg/L PBTK NA 95% Human Human +DTXSID0047296 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0047296 Fup 0.0091 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0047296 Vd NA 0.1984 L/kg 1compartment NA NA Rat Human -DTXSID0047296 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0047296 TK.Half.Life NA 20.56 hours 1compartment NA NA Rat Human -DTXSID0047296 Css NA 9.708 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047296 Css NA 29.59 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047296 Css NA 5.36 mg/L PBTK NA 50% Rat Human -DTXSID0047296 Css NA 16.15 mg/L PBTK NA 95% Rat Human -DTXSID0047325 Clint NA 102.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047325 Fup NA 0.0176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047325 Vd NA 3.016 L/kg 1compartment NA NA Human Human +DTXSID0047296 Vd NA 0.1945 L/kg 1compartment NA NA Rat Human +DTXSID0047296 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0047296 TK.Half.Life NA 7.884 hours 1compartment NA NA Rat Human +DTXSID0047296 Css NA 0.3088 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047296 Css NA 1.771 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047296 Css NA 0.1733 mg/L PBTK NA 50% Rat Human +DTXSID0047296 Css NA 0.9953 mg/L PBTK NA 95% Rat Human +DTXSID0047298 Clint 7.464 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047298 Fup 0.0195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047298 Vd NA 2.648 L/kg 1compartment NA NA Human Human +DTXSID0047298 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID0047298 TK.Half.Life NA 96.96 hours 1compartment NA NA Human Human +DTXSID0047298 Css NA 5.15 mg/L 3compartmentss NA 50% Human Human +DTXSID0047298 Css NA 33.94 mg/L 3compartmentss NA 95% Human Human +DTXSID0047298 Css NA 3.47 mg/L PBTK NA 50% Human Human +DTXSID0047298 Css NA 21.87 mg/L PBTK NA 95% Human Human +DTXSID0047298 Clint 7.464 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047298 Fup 0.0195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047298 Vd NA 1.995 L/kg 1compartment NA NA Rat Human +DTXSID0047298 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID0047298 TK.Half.Life NA 21.77 hours 1compartment NA NA Rat Human +DTXSID0047298 Css NA 0.6542 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047298 Css NA 3.369 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047298 Css NA 0.4326 mg/L PBTK NA 50% Rat Human +DTXSID0047298 Css NA 2.137 mg/L PBTK NA 95% Rat Human +DTXSID0047325 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047325 Fup 0.0429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047325 Vd NA 3.177 L/kg 1compartment NA NA Human Human DTXSID0047325 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047325 TK.Half.Life NA 5.056 hours 1compartment NA NA Human Human -DTXSID0047325 Css NA 0.1172 mg/L 3compartmentss NA 50% Human Human -DTXSID0047325 Css NA 0.833 mg/L 3compartmentss NA 95% Human Human -DTXSID0047325 Css NA 0.08202 mg/L PBTK NA 50% Human Human -DTXSID0047325 Css NA 0.5551 mg/L PBTK NA 95% Human Human -DTXSID0047325 Clint NA 102.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047325 Fup NA 0.0176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047325 Vd NA 2.308 L/kg 1compartment NA NA Rat Human +DTXSID0047325 TK.Half.Life NA 14.09 hours 1compartment NA NA Human Human +DTXSID0047325 Css NA 0.4457 mg/L 3compartmentss NA 50% Human Human +DTXSID0047325 Css NA 3.125 mg/L 3compartmentss NA 95% Human Human +DTXSID0047325 Css NA 0.3186 mg/L PBTK NA 50% Human Human +DTXSID0047325 Css NA 2.161 mg/L PBTK NA 95% Human Human +DTXSID0047325 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047325 Fup 0.0429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047325 Vd NA 2.449 L/kg 1compartment NA NA Rat Human DTXSID0047325 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047325 TK.Half.Life NA 1.292 hours 1compartment NA NA Rat Human -DTXSID0047325 Css NA 0.0659 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047325 Css NA 0.3983 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047325 Css NA 0.04387 mg/L PBTK NA 50% Rat Human -DTXSID0047325 Css NA 0.2525 mg/L PBTK NA 95% Rat Human -DTXSID0047327 Clint NA 391.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047327 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047327 Vd NA 6.71 L/kg 1compartment NA NA Human Human -DTXSID0047327 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047327 TK.Half.Life NA 12.28 hours 1compartment NA NA Human Human -DTXSID0047327 Css NA 0.119 mg/L 3compartmentss NA 50% Human Human -DTXSID0047327 Css NA 0.8273 mg/L 3compartmentss NA 95% Human Human -DTXSID0047327 Css NA 0.1095 mg/L PBTK NA 50% Human Human -DTXSID0047327 Css NA 0.6774 mg/L PBTK NA 95% Human Human -DTXSID0047327 Clint NA 391.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047327 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047327 Vd NA 5.191 L/kg 1compartment NA NA Rat Human -DTXSID0047327 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047327 TK.Half.Life NA 2.572 hours 1compartment NA NA Rat Human -DTXSID0047327 Css NA 0.06518 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047327 Css NA 0.3769 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047327 Css NA 0.05959 mg/L PBTK NA 50% Rat Human -DTXSID0047327 Css NA 0.3187 mg/L PBTK NA 95% Rat Human -DTXSID0047371 Clint NA 21.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047371 Fup NA 0.0588 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047371 Vd NA 2.304 L/kg 1compartment NA NA Human Human -DTXSID0047371 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047371 TK.Half.Life NA 4.636 hours 1compartment NA NA Human Human -DTXSID0047371 Css NA 0.1844 mg/L 3compartmentss NA 50% Human Human -DTXSID0047371 Css NA 1.695 mg/L 3compartmentss NA 95% Human Human -DTXSID0047371 Css NA 0.1496 mg/L PBTK NA 50% Human Human -DTXSID0047371 Css NA 1.201 mg/L PBTK NA 95% Human Human -DTXSID0047371 Clint NA 21.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047371 Fup NA 0.0588 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047371 Vd NA 2.225 L/kg 1compartment NA NA Rat Human -DTXSID0047371 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047371 TK.Half.Life NA 2.585 hours 1compartment NA NA Rat Human -DTXSID0047371 Css NA 0.1048 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047371 Css NA 0.747 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047371 Css NA 0.08124 mg/L PBTK NA 50% Rat Human -DTXSID0047371 Css NA 0.5006 mg/L PBTK NA 95% Rat Human -DTXSID0047375 Clint NA 1.096 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047375 Fup NA 0.0072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047375 Vd NA 0.2409 L/kg 1compartment NA NA Human Human -DTXSID0047375 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID0047375 TK.Half.Life NA 75.76 hours 1compartment NA NA Human Human -DTXSID0047375 Css NA 55.27 mg/L 3compartmentss NA 50% Human Human -DTXSID0047375 Css NA 370 mg/L 3compartmentss NA 95% Human Human -DTXSID0047375 Css NA 33 mg/L PBTK NA 50% Human Human -DTXSID0047375 Css NA 216.7 mg/L PBTK NA 95% Human Human -DTXSID0047375 Clint NA 1.096 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047375 Fup NA 0.0072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047375 Vd NA 0.2294 L/kg 1compartment NA NA Rat Human -DTXSID0047375 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID0047375 TK.Half.Life NA 36.91 hours 1compartment NA NA Rat Human -DTXSID0047375 Css NA 23.63 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047375 Css NA 138.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047375 Css NA 13.07 mg/L PBTK NA 50% Rat Human -DTXSID0047375 Css NA 75.09 mg/L PBTK NA 95% Rat Human -DTXSID0047377 Clint NA 134.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047377 Fup NA 0.0331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047377 Vd NA 2.652 L/kg 1compartment NA NA Human Human -DTXSID0047377 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047377 TK.Half.Life NA 6.279 hours 1compartment NA NA Human Human -DTXSID0047377 Css NA 0.227 mg/L 3compartmentss NA 50% Human Human -DTXSID0047377 Css NA 1.586 mg/L 3compartmentss NA 95% Human Human -DTXSID0047377 Css NA 0.1525 mg/L PBTK NA 50% Human Human -DTXSID0047377 Css NA 1.01 mg/L PBTK NA 95% Human Human -DTXSID0047377 Clint NA 134.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047377 Fup NA 0.0331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047377 Vd NA 1.988 L/kg 1compartment NA NA Rat Human -DTXSID0047377 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047377 TK.Half.Life NA 1.626 hours 1compartment NA NA Rat Human -DTXSID0047377 Css NA 0.1263 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047377 Css NA 0.7333 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047377 Css NA 0.0809 mg/L PBTK NA 50% Rat Human -DTXSID0047377 Css NA 0.4574 mg/L PBTK NA 95% Rat Human -DTXSID0047404 Clint NA 7.554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047404 Fup NA 0.2704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047404 Vd NA 3.278 L/kg 1compartment NA NA Human Human +DTXSID0047325 TK.Half.Life NA 2.711 hours 1compartment NA NA Rat Human +DTXSID0047325 Css NA 0.05812 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047325 Css NA 0.3474 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047325 Css NA 0.04116 mg/L PBTK NA 50% Rat Human +DTXSID0047325 Css NA 0.2378 mg/L PBTK NA 95% Rat Human +DTXSID0047371 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047371 Fup 0.0433 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047371 Vd NA 2.755 L/kg 1compartment NA NA Human Human +DTXSID0047371 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0047371 TK.Half.Life NA 27.2 hours 1compartment NA NA Human Human +DTXSID0047371 Css NA 1.242 mg/L 3compartmentss NA 50% Human Human +DTXSID0047371 Css NA 8.22 mg/L 3compartmentss NA 95% Human Human +DTXSID0047371 Css NA 0.8395 mg/L PBTK NA 50% Human Human +DTXSID0047371 Css NA 5.401 mg/L PBTK NA 95% Human Human +DTXSID0047371 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047371 Fup 0.0433 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047371 Vd NA 2.063 L/kg 1compartment NA NA Rat Human +DTXSID0047371 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0047371 TK.Half.Life NA 5.686 hours 1compartment NA NA Rat Human +DTXSID0047371 Css NA 0.1606 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047371 Css NA 0.8655 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047371 Css NA 0.1074 mg/L PBTK NA 50% Rat Human +DTXSID0047371 Css NA 0.5593 mg/L PBTK NA 95% Rat Human +DTXSID0047375 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047375 Fup 0.0277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047375 Vd NA 0.3482 L/kg 1compartment NA NA Human Human +DTXSID0047375 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047375 TK.Half.Life NA 2.478 hours 1compartment NA NA Human Human +DTXSID0047375 Css NA 0.9861 mg/L 3compartmentss NA 50% Human Human +DTXSID0047375 Css NA 9.937 mg/L 3compartmentss NA 95% Human Human +DTXSID0047375 Css NA 0.6051 mg/L PBTK NA 50% Human Human +DTXSID0047375 Css NA 5.913 mg/L PBTK NA 95% Human Human +DTXSID0047375 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047375 Fup 0.0277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047375 Vd NA 0.3351 L/kg 1compartment NA NA Rat Human +DTXSID0047375 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0047375 TK.Half.Life NA 1.549 hours 1compartment NA NA Rat Human +DTXSID0047375 Css NA 0.04821 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047375 Css NA 0.5457 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047375 Css NA 0.02866 mg/L PBTK NA 50% Rat Human +DTXSID0047375 Css NA 0.312 mg/L PBTK NA 95% Rat Human +DTXSID0047377 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047377 Fup 0.0326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047377 Vd NA 2.836 L/kg 1compartment NA NA Human Human +DTXSID0047377 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID0047377 TK.Half.Life NA 35.66 hours 1compartment NA NA Human Human +DTXSID0047377 Css NA 1.396 mg/L 3compartmentss NA 50% Human Human +DTXSID0047377 Css NA 9.493 mg/L 3compartmentss NA 95% Human Human +DTXSID0047377 Css NA 0.9516 mg/L PBTK NA 50% Human Human +DTXSID0047377 Css NA 6.242 mg/L PBTK NA 95% Human Human +DTXSID0047377 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047377 Fup 0.0326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047377 Vd NA 2.127 L/kg 1compartment NA NA Rat Human +DTXSID0047377 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0047377 TK.Half.Life NA 6.938 hours 1compartment NA NA Rat Human +DTXSID0047377 Css NA 0.07178 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047377 Css NA 0.508 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047377 Css NA 0.04713 mg/L PBTK NA 50% Rat Human +DTXSID0047377 Css NA 0.3199 mg/L PBTK NA 95% Rat Human +DTXSID0047379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047379 Fup 0.0244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047379 Vd NA 3.123 L/kg 1compartment NA NA Human Human +DTXSID0047379 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID0047379 TK.Half.Life NA 90.84 hours 1compartment NA NA Human Human +DTXSID0047379 Css NA 3.009 mg/L 3compartmentss NA 50% Human Human +DTXSID0047379 Css NA 18.2 mg/L 3compartmentss NA 95% Human Human +DTXSID0047379 Css NA 2.093 mg/L PBTK NA 50% Human Human +DTXSID0047379 Css NA 12.41 mg/L PBTK NA 95% Human Human +DTXSID0047379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047379 Fup 0.0244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047379 Vd NA 2.339 L/kg 1compartment NA NA Rat Human +DTXSID0047379 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID0047379 TK.Half.Life NA 12.17 hours 1compartment NA NA Rat Human +DTXSID0047379 Css NA 0.1522 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047379 Css NA 0.9665 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047379 Css NA 0.1029 mg/L PBTK NA 50% Rat Human +DTXSID0047379 Css NA 0.6281 mg/L PBTK NA 95% Rat Human +DTXSID0047404 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047404 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047404 Vd NA 1.438 L/kg 1compartment NA NA Human Human DTXSID0047404 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047404 TK.Half.Life NA 8.032 hours 1compartment NA NA Human Human -DTXSID0047404 Css NA 0.1765 mg/L 3compartmentss NA 50% Human Human -DTXSID0047404 Css NA 1.121 mg/L 3compartmentss NA 95% Human Human -DTXSID0047404 Css NA 0.1776 mg/L PBTK NA 50% Human Human -DTXSID0047404 Css NA 0.9633 mg/L PBTK NA 95% Human Human -DTXSID0047404 Clint NA 7.554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047404 Fup NA 0.2704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047404 Vd NA 3.095 L/kg 1compartment NA NA Rat Human +DTXSID0047404 TK.Half.Life NA 2.714 hours 1compartment NA NA Human Human +DTXSID0047404 Css NA 0.135 mg/L 3compartmentss NA 50% Human Human +DTXSID0047404 Css NA 0.982 mg/L 3compartmentss NA 95% Human Human +DTXSID0047404 Css NA 0.1171 mg/L PBTK NA 50% Human Human +DTXSID0047404 Css NA 0.6967 mg/L PBTK NA 95% Human Human +DTXSID0047404 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047404 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047404 Vd NA 1.449 L/kg 1compartment NA NA Rat Human DTXSID0047404 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047404 TK.Half.Life NA 3.796 hours 1compartment NA NA Rat Human -DTXSID0047404 Css NA 0.08934 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047404 Css NA 0.4352 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047404 Css NA 0.08827 mg/L PBTK NA 50% Rat Human -DTXSID0047404 Css NA 0.3531 mg/L PBTK NA 95% Rat Human -DTXSID0047406 Clint NA 14.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047406 Fup NA 0.0238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047406 Vd NA 2.617 L/kg 1compartment NA NA Human Human -DTXSID0047406 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID0047406 TK.Half.Life NA 46.24 hours 1compartment NA NA Human Human -DTXSID0047406 Css NA 2.514 mg/L 3compartmentss NA 50% Human Human -DTXSID0047406 Css NA 17.22 mg/L 3compartmentss NA 95% Human Human -DTXSID0047406 Css NA 1.68 mg/L PBTK NA 50% Human Human -DTXSID0047406 Css NA 11.01 mg/L PBTK NA 95% Human Human -DTXSID0047406 Clint NA 14.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047406 Fup NA 0.0238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047406 Vd NA 1.956 L/kg 1compartment NA NA Rat Human +DTXSID0047404 TK.Half.Life NA 1.547 hours 1compartment NA NA Rat Human +DTXSID0047404 Css NA 0.01546 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047404 Css NA 0.08718 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047404 Css NA 0.01337 mg/L PBTK NA 50% Rat Human +DTXSID0047404 Css NA 0.06003 mg/L PBTK NA 95% Rat Human +DTXSID0047406 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047406 Fup 0.0114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047406 Vd NA 2.57 L/kg 1compartment NA NA Human Human +DTXSID0047406 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID0047406 TK.Half.Life NA 44.01 hours 1compartment NA NA Human Human +DTXSID0047406 Css NA 2.39 mg/L 3compartmentss NA 50% Human Human +DTXSID0047406 Css NA 17.61 mg/L 3compartmentss NA 95% Human Human +DTXSID0047406 Css NA 1.585 mg/L PBTK NA 50% Human Human +DTXSID0047406 Css NA 11.31 mg/L PBTK NA 95% Human Human +DTXSID0047406 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047406 Fup 0.0114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047406 Vd NA 1.916 L/kg 1compartment NA NA Rat Human DTXSID0047406 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0047406 TK.Half.Life NA 10.41 hours 1compartment NA NA Rat Human -DTXSID0047406 Css NA 1.374 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047406 Css NA 7.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047406 Css NA 0.8702 mg/L PBTK NA 50% Rat Human -DTXSID0047406 Css NA 4.46 mg/L PBTK NA 95% Rat Human -DTXSID0047450 Clint NA 0.6623 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047450 Fup NA 0.1135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047450 Vd NA 0.4857 L/kg 1compartment NA NA Human Human -DTXSID0047450 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0047450 TK.Half.Life NA 13.37 hours 1compartment NA NA Human Human -DTXSID0047450 Css NA 4.135 mg/L 3compartmentss NA 50% Human Human -DTXSID0047450 Css NA 20.65 mg/L 3compartmentss NA 95% Human Human -DTXSID0047450 Css NA 2.617 mg/L PBTK NA 50% Human Human -DTXSID0047450 Css NA 12.28 mg/L PBTK NA 95% Human Human -DTXSID0047450 Clint NA 0.6623 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047450 Fup NA 0.1135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047450 Vd NA 0.4251 L/kg 1compartment NA NA Rat Human +DTXSID0047406 TK.Half.Life NA 10.28 hours 1compartment NA NA Rat Human +DTXSID0047406 Css NA 0.3093 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047406 Css NA 1.994 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047406 Css NA 0.2009 mg/L PBTK NA 50% Rat Human +DTXSID0047406 Css NA 1.25 mg/L PBTK NA 95% Rat Human +DTXSID0047450 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047450 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047450 Vd NA 0.7555 L/kg 1compartment NA NA Human Human +DTXSID0047450 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047450 TK.Half.Life NA 2.159 hours 1compartment NA NA Human Human +DTXSID0047450 Css NA 0.2632 mg/L 3compartmentss NA 50% Human Human +DTXSID0047450 Css NA 1.643 mg/L 3compartmentss NA 95% Human Human +DTXSID0047450 Css NA 0.1854 mg/L PBTK NA 50% Human Human +DTXSID0047450 Css NA 1.069 mg/L PBTK NA 95% Human Human +DTXSID0047450 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047450 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047450 Vd NA 0.6622 L/kg 1compartment NA NA Rat Human DTXSID0047450 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047450 TK.Half.Life NA 5.373 hours 1compartment NA NA Rat Human -DTXSID0047450 Css NA 1.631 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047450 Css NA 6.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047450 Css NA 0.9628 mg/L PBTK NA 50% Rat Human -DTXSID0047450 Css NA 3.699 mg/L PBTK NA 95% Rat Human -DTXSID0047454 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047454 Fup NA 0.3429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047454 Vd NA 0.597 L/kg 1compartment NA NA Human Human -DTXSID0047454 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0047454 TK.Half.Life NA 11.26 hours 1compartment NA NA Human Human -DTXSID0047454 Css NA 2.077 mg/L 3compartmentss NA 50% Human Human -DTXSID0047454 Css NA 8.522 mg/L 3compartmentss NA 95% Human Human -DTXSID0047454 Css NA 1.563 mg/L PBTK NA 50% Human Human -DTXSID0047454 Css NA 5.491 mg/L PBTK NA 95% Human Human -DTXSID0047454 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047454 Fup NA 0.3429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047454 Vd NA 0.6018 L/kg 1compartment NA NA Rat Human +DTXSID0047450 TK.Half.Life NA 1.066 hours 1compartment NA NA Rat Human +DTXSID0047450 Css NA 0.03102 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047450 Css NA 0.1365 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047450 Css NA 0.02166 mg/L PBTK NA 50% Rat Human +DTXSID0047450 Css NA 0.08719 mg/L PBTK NA 95% Rat Human +DTXSID0047454 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047454 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047454 Vd NA 0.8153 L/kg 1compartment NA NA Human Human +DTXSID0047454 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047454 TK.Half.Life NA 9.095 hours 1compartment NA NA Human Human +DTXSID0047454 Css NA 1.143 mg/L 3compartmentss NA 50% Human Human +DTXSID0047454 Css NA 8.209 mg/L 3compartmentss NA 95% Human Human +DTXSID0047454 Css NA 0.983 mg/L PBTK NA 50% Human Human +DTXSID0047454 Css NA 5.293 mg/L PBTK NA 95% Human Human +DTXSID0047454 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047454 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047454 Vd NA 0.8251 L/kg 1compartment NA NA Rat Human DTXSID0047454 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047454 TK.Half.Life NA 3.87 hours 1compartment NA NA Rat Human -DTXSID0047454 Css NA 0.5604 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047454 Css NA 2.039 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047454 Css NA 0.4048 mg/L PBTK NA 50% Rat Human -DTXSID0047454 Css NA 1.224 mg/L PBTK NA 95% Rat Human -DTXSID0047456 Clint NA 7.046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047456 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047456 Vd NA 1.332 L/kg 1compartment NA NA Human Human -DTXSID0047456 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047456 TK.Half.Life NA 1.286 hours 1compartment NA NA Human Human -DTXSID0047456 Css NA 0.0623 mg/L 3compartmentss NA 50% Human Human -DTXSID0047456 Css NA 0.6857 mg/L 3compartmentss NA 95% Human Human -DTXSID0047456 Css NA 0.05766 mg/L PBTK NA 50% Human Human -DTXSID0047456 Css NA 0.5137 mg/L PBTK NA 95% Human Human -DTXSID0047456 Clint NA 7.046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047456 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047456 Vd NA 1.257 L/kg 1compartment NA NA Rat Human +DTXSID0047454 TK.Half.Life NA 3.138 hours 1compartment NA NA Rat Human +DTXSID0047454 Css NA 0.06936 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047454 Css NA 0.4583 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047454 Css NA 0.05944 mg/L PBTK NA 50% Rat Human +DTXSID0047454 Css NA 0.285 mg/L PBTK NA 95% Rat Human +DTXSID0047456 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047456 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047456 Vd NA 0.7099 L/kg 1compartment NA NA Human Human +DTXSID0047456 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0047456 TK.Half.Life NA 9.654 hours 1compartment NA NA Human Human +DTXSID0047456 Css NA 1.43 mg/L 3compartmentss NA 50% Human Human +DTXSID0047456 Css NA 7.007 mg/L 3compartmentss NA 95% Human Human +DTXSID0047456 Css NA 1.112 mg/L PBTK NA 50% Human Human +DTXSID0047456 Css NA 4.532 mg/L PBTK NA 95% Human Human +DTXSID0047456 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047456 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047456 Vd NA 0.6942 L/kg 1compartment NA NA Rat Human DTXSID0047456 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047456 TK.Half.Life NA 0.6156 hours 1compartment NA NA Rat Human -DTXSID0047456 Css NA 0.02926 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047456 Css NA 0.2392 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047456 Css NA 0.0273 mg/L PBTK NA 50% Rat Human -DTXSID0047456 Css NA 0.1671 mg/L PBTK NA 95% Rat Human -DTXSID0047533 Clint NA 313.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047533 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047533 Vd NA 941.4 L/kg 1compartment NA NA Human Human -DTXSID0047533 Days.Css NA 500 Days PBTK NA NA Human Human -DTXSID0047533 TK.Half.Life NA 1981 hours 1compartment NA NA Human Human -DTXSID0047533 Css NA 0.001184 mg/L 3compartmentss NA 50% Human Human -DTXSID0047533 Css NA 0.007269 mg/L 3compartmentss NA 95% Human Human -DTXSID0047533 Css NA 0.1765 mg/L PBTK NA 50% Human Human -DTXSID0047533 Css NA 0.9862 mg/L PBTK NA 95% Human Human -DTXSID0047533 Clint NA 313.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047533 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047533 Vd NA 861.3 L/kg 1compartment NA NA Rat Human -DTXSID0047533 Days.Css NA 341 Days PBTK NA NA Rat Human -DTXSID0047533 TK.Half.Life NA 342.6 hours 1compartment NA NA Rat Human -DTXSID0047533 Css NA 0.0005998 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047533 Css NA 0.002559 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047533 Css NA 0.09483 mg/L PBTK NA 50% Rat Human -DTXSID0047533 Css NA 0.3942 mg/L PBTK NA 95% Rat Human -DTXSID0047535 Clint NA 1084 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047535 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047535 Vd NA 2.715 L/kg 1compartment NA NA Human Human -DTXSID0047535 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047535 TK.Half.Life NA 3.288 hours 1compartment NA NA Human Human -DTXSID0047535 Css NA 0.05417 mg/L 3compartmentss NA 50% Human Human -DTXSID0047535 Css NA 0.3867 mg/L 3compartmentss NA 95% Human Human -DTXSID0047535 Css NA 0.03631 mg/L PBTK NA 50% Human Human -DTXSID0047535 Css NA 0.2507 mg/L PBTK NA 95% Human Human -DTXSID0047535 Clint NA 1084 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047535 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047535 Vd NA 2.027 L/kg 1compartment NA NA Rat Human -DTXSID0047535 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047535 TK.Half.Life NA 0.9532 hours 1compartment NA NA Rat Human -DTXSID0047535 Css NA 0.03036 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047535 Css NA 0.1821 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047535 Css NA 0.01919 mg/L PBTK NA 50% Rat Human -DTXSID0047535 Css NA 0.1123 mg/L PBTK NA 95% Rat Human -DTXSID0047537 Clint NA 258.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047537 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047537 Vd NA 1180 L/kg 1compartment NA NA Human Human -DTXSID0047537 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID0047537 TK.Half.Life NA 2961 hours 1compartment NA NA Human Human -DTXSID0047537 Css NA 0.001105 mg/L 3compartmentss NA 50% Human Human -DTXSID0047537 Css NA 0.006661 mg/L 3compartmentss NA 95% Human Human -DTXSID0047537 Css NA 0.2096 mg/L PBTK NA 50% Human Human -DTXSID0047537 Css NA 1.139 mg/L PBTK NA 95% Human Human -DTXSID0047537 Clint NA 258.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047537 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047537 Vd NA 1083 L/kg 1compartment NA NA Rat Human -DTXSID0047537 Days.Css NA 518 Days PBTK NA NA Rat Human -DTXSID0047537 TK.Half.Life NA 490.6 hours 1compartment NA NA Rat Human -DTXSID0047537 Css NA 0.0005553 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047537 Css NA 0.002462 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047537 Css NA 0.1131 mg/L PBTK NA 50% Rat Human -DTXSID0047537 Css NA 0.4799 mg/L PBTK NA 95% Rat Human -DTXSID0047539 Clint NA 61.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047539 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047539 Vd NA 1.869 L/kg 1compartment NA NA Human Human -DTXSID0047539 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047539 TK.Half.Life NA 9.149 hours 1compartment NA NA Human Human -DTXSID0047539 Css NA 0.6949 mg/L 3compartmentss NA 50% Human Human -DTXSID0047539 Css NA 5.51 mg/L 3compartmentss NA 95% Human Human -DTXSID0047539 Css NA 0.4428 mg/L PBTK NA 50% Human Human -DTXSID0047539 Css NA 3.392 mg/L PBTK NA 95% Human Human -DTXSID0047539 Clint NA 61.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047539 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047539 Vd NA 1.386 L/kg 1compartment NA NA Rat Human -DTXSID0047539 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047539 TK.Half.Life NA 3.11 hours 1compartment NA NA Rat Human -DTXSID0047539 Css NA 0.3834 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047539 Css NA 2.783 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047539 Css NA 0.2302 mg/L PBTK NA 50% Rat Human -DTXSID0047539 Css NA 1.605 mg/L PBTK NA 95% Rat Human -DTXSID0047587 Clint NA 11.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047587 Fup NA 0.2712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047587 Vd NA 2.671 L/kg 1compartment NA NA Human Human -DTXSID0047587 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047587 TK.Half.Life NA 11.14 hours 1compartment NA NA Human Human -DTXSID0047587 Css NA 0.411 mg/L 3compartmentss NA 50% Human Human -DTXSID0047587 Css NA 2.448 mg/L 3compartmentss NA 95% Human Human -DTXSID0047587 Css NA 0.3036 mg/L PBTK NA 50% Human Human -DTXSID0047587 Css NA 1.706 mg/L PBTK NA 95% Human Human -DTXSID0047587 Clint NA 11.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047587 Fup NA 0.2712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047587 Vd NA 2.038 L/kg 1compartment NA NA Rat Human -DTXSID0047587 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047587 TK.Half.Life NA 2.693 hours 1compartment NA NA Rat Human -DTXSID0047587 Css NA 0.2202 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047587 Css NA 0.9363 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047587 Css NA 0.156 mg/L PBTK NA 50% Rat Human -DTXSID0047587 Css NA 0.642 mg/L PBTK NA 95% Rat Human -DTXSID0047589 Clint NA 8.225 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047589 Fup NA 0.146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047589 Vd NA 2.449 L/kg 1compartment NA NA Human Human -DTXSID0047589 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0047589 TK.Half.Life NA 17.25 hours 1compartment NA NA Human Human -DTXSID0047589 Css NA 0.8502 mg/L 3compartmentss NA 50% Human Human -DTXSID0047589 Css NA 4.964 mg/L 3compartmentss NA 95% Human Human -DTXSID0047589 Css NA 0.5966 mg/L PBTK NA 50% Human Human -DTXSID0047589 Css NA 3.299 mg/L PBTK NA 95% Human Human -DTXSID0047589 Clint NA 8.225 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047589 Fup NA 0.146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047589 Vd NA 1.856 L/kg 1compartment NA NA Rat Human +DTXSID0047456 TK.Half.Life NA 3.191 hours 1compartment NA NA Rat Human +DTXSID0047456 Css NA 0.09068 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047456 Css NA 0.4075 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047456 Css NA 0.07006 mg/L PBTK NA 50% Rat Human +DTXSID0047456 Css NA 0.2522 mg/L PBTK NA 95% Rat Human +DTXSID0047535 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047535 Fup 0.0276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047535 Vd NA 2.446 L/kg 1compartment NA NA Human Human +DTXSID0047535 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0047535 TK.Half.Life NA 24.44 hours 1compartment NA NA Human Human +DTXSID0047535 Css NA 1.2 mg/L 3compartmentss NA 50% Human Human +DTXSID0047535 Css NA 9.491 mg/L 3compartmentss NA 95% Human Human +DTXSID0047535 Css NA 0.7962 mg/L PBTK NA 50% Human Human +DTXSID0047535 Css NA 5.972 mg/L PBTK NA 95% Human Human +DTXSID0047535 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047535 Fup 0.0276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047535 Vd NA 1.826 L/kg 1compartment NA NA Rat Human +DTXSID0047535 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0047535 TK.Half.Life NA 6.296 hours 1compartment NA NA Rat Human +DTXSID0047535 Css NA 0.06158 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047535 Css NA 0.4796 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047535 Css NA 0.03962 mg/L PBTK NA 50% Rat Human +DTXSID0047535 Css NA 0.293 mg/L PBTK NA 95% Rat Human +DTXSID0047539 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047539 Fup 0.0044 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047539 Vd NA 2.173 L/kg 1compartment NA NA Human Human +DTXSID0047539 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID0047539 TK.Half.Life NA 52.31 hours 1compartment NA NA Human Human +DTXSID0047539 Css NA 3.653 mg/L 3compartmentss NA 50% Human Human +DTXSID0047539 Css NA 31.01 mg/L 3compartmentss NA 95% Human Human +DTXSID0047539 Css NA 2.329 mg/L PBTK NA 50% Human Human +DTXSID0047539 Css NA 18.88 mg/L PBTK NA 95% Human Human +DTXSID0047539 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047539 Fup 0.0044 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047539 Vd NA 1.61 L/kg 1compartment NA NA Rat Human +DTXSID0047539 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0047539 TK.Half.Life NA 15.41 hours 1compartment NA NA Rat Human +DTXSID0047539 Css NA 0.4752 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047539 Css NA 3.255 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047539 Css NA 0.298 mg/L PBTK NA 50% Rat Human +DTXSID0047539 Css NA 1.956 mg/L PBTK NA 95% Rat Human +DTXSID0047589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047589 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047589 Vd NA 2.425 L/kg 1compartment NA NA Human Human +DTXSID0047589 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047589 TK.Half.Life NA 7.721 hours 1compartment NA NA Human Human +DTXSID0047589 Css NA 0.3156 mg/L 3compartmentss NA 50% Human Human +DTXSID0047589 Css NA 2.188 mg/L 3compartmentss NA 95% Human Human +DTXSID0047589 Css NA 0.221 mg/L PBTK NA 50% Human Human +DTXSID0047589 Css NA 1.456 mg/L PBTK NA 95% Human Human +DTXSID0047589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047589 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047589 Vd NA 1.839 L/kg 1compartment NA NA Rat Human DTXSID0047589 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047589 TK.Half.Life NA 4.507 hours 1compartment NA NA Rat Human -DTXSID0047589 Css NA 0.455 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047589 Css NA 1.951 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047589 Css NA 0.3059 mg/L PBTK NA 50% Rat Human -DTXSID0047589 Css NA 1.253 mg/L PBTK NA 95% Rat Human +DTXSID0047589 TK.Half.Life NA 2.169 hours 1compartment NA NA Rat Human +DTXSID0047589 Css NA 0.04015 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047589 Css NA 0.2157 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047589 Css NA 0.02796 mg/L PBTK NA 50% Rat Human +DTXSID0047589 Css NA 0.1445 mg/L PBTK NA 95% Rat Human +DTXSID0047610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047610 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047610 Vd NA 1.204 L/kg 1compartment NA NA Human Human +DTXSID0047610 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047610 TK.Half.Life NA 1.732 hours 1compartment NA NA Human Human +DTXSID0047610 Css NA 0.08302 mg/L 3compartmentss NA 50% Human Human +DTXSID0047610 Css NA 0.6064 mg/L 3compartmentss NA 95% Human Human +DTXSID0047610 Css NA 0.06128 mg/L PBTK NA 50% Human Human +DTXSID0047610 Css NA 0.4098 mg/L PBTK NA 95% Human Human +DTXSID0047610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047610 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047610 Vd NA 0.9915 L/kg 1compartment NA NA Rat Human +DTXSID0047610 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0047610 TK.Half.Life NA 0.7304 hours 1compartment NA NA Rat Human +DTXSID0047610 Css NA 0.01034 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047610 Css NA 0.05752 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047610 Css NA 0.007552 mg/L PBTK NA 50% Rat Human +DTXSID0047610 Css NA 0.03862 mg/L PBTK NA 95% Rat Human DTXSID0047618 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0047618 Fup NA 0.8849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047618 Vd NA 0.877 L/kg 1compartment NA NA Human Human +DTXSID0047618 Vd NA 0.891 L/kg 1compartment NA NA Human Human DTXSID0047618 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047618 TK.Half.Life NA 6.454 hours 1compartment NA NA Human Human -DTXSID0047618 Css NA 0.9116 mg/L 3compartmentss NA 50% Human Human -DTXSID0047618 Css NA 5.151 mg/L 3compartmentss NA 95% Human Human -DTXSID0047618 Css NA 0.779 mg/L PBTK NA 50% Human Human -DTXSID0047618 Css NA 3.398 mg/L PBTK NA 95% Human Human +DTXSID0047618 TK.Half.Life NA 6.564 hours 1compartment NA NA Human Human +DTXSID0047618 Css NA 0.7637 mg/L 3compartmentss NA 50% Human Human +DTXSID0047618 Css NA 4.239 mg/L 3compartmentss NA 95% Human Human +DTXSID0047618 Css NA 0.6608 mg/L PBTK NA 50% Human Human +DTXSID0047618 Css NA 2.819 mg/L PBTK NA 95% Human Human DTXSID0047618 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0047618 Fup NA 0.8849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047618 Vd NA 0.8884 L/kg 1compartment NA NA Rat Human +DTXSID0047618 Vd NA 0.8998 L/kg 1compartment NA NA Rat Human DTXSID0047618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047618 TK.Half.Life NA 2.217 hours 1compartment NA NA Rat Human -DTXSID0047618 Css NA 0.2306 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047618 Css NA 1.337 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047618 Css NA 0.1921 mg/L PBTK NA 50% Rat Human -DTXSID0047618 Css NA 0.8141 mg/L PBTK NA 95% Rat Human -DTXSID0047660 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047660 Fup NA 0.9268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047660 Vd NA 1.082 L/kg 1compartment NA NA Human Human -DTXSID0047660 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047660 TK.Half.Life NA 7.743 hours 1compartment NA NA Human Human -DTXSID0047660 Css NA 0.8184 mg/L 3compartmentss NA 50% Human Human -DTXSID0047660 Css NA 3.089 mg/L 3compartmentss NA 95% Human Human -DTXSID0047660 Css NA 0.736 mg/L PBTK NA 50% Human Human -DTXSID0047660 Css NA 2.232 mg/L PBTK NA 95% Human Human -DTXSID0047660 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047660 Fup NA 0.9268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047660 Vd NA 1.056 L/kg 1compartment NA NA Rat Human +DTXSID0047618 TK.Half.Life NA 2.246 hours 1compartment NA NA Rat Human +DTXSID0047618 Css NA 0.01428 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047618 Css NA 0.1084 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047618 Css NA 0.01177 mg/L PBTK NA 50% Rat Human +DTXSID0047618 Css NA 0.07255 mg/L PBTK NA 95% Rat Human +DTXSID0047660 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047660 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047660 Vd NA 0.9348 L/kg 1compartment NA NA Human Human +DTXSID0047660 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0047660 TK.Half.Life NA 9.933 hours 1compartment NA NA Human Human +DTXSID0047660 Css NA 1.116 mg/L 3compartmentss NA 50% Human Human +DTXSID0047660 Css NA 7.808 mg/L 3compartmentss NA 95% Human Human +DTXSID0047660 Css NA 0.9402 mg/L PBTK NA 50% Human Human +DTXSID0047660 Css NA 5.027 mg/L PBTK NA 95% Human Human +DTXSID0047660 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047660 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047660 Vd NA 0.8927 L/kg 1compartment NA NA Rat Human DTXSID0047660 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047660 TK.Half.Life NA 2.528 hours 1compartment NA NA Rat Human -DTXSID0047660 Css NA 0.2087 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047660 Css NA 0.7457 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047660 Css NA 0.1839 mg/L PBTK NA 50% Rat Human -DTXSID0047660 Css NA 0.4968 mg/L PBTK NA 95% Rat Human -DTXSID0047662 Clint NA 54.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047662 Fup NA 0.0694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047662 Vd NA 1.041 L/kg 1compartment NA NA Human Human +DTXSID0047660 TK.Half.Life NA 3.165 hours 1compartment NA NA Rat Human +DTXSID0047660 Css NA 0.06915 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047660 Css NA 0.4475 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047660 Css NA 0.05779 mg/L PBTK NA 50% Rat Human +DTXSID0047660 Css NA 0.2763 mg/L PBTK NA 95% Rat Human +DTXSID0047662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047662 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047662 Vd NA 1.987 L/kg 1compartment NA NA Human Human DTXSID0047662 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047662 TK.Half.Life NA 1.999 hours 1compartment NA NA Human Human -DTXSID0047662 Css NA 0.1825 mg/L 3compartmentss NA 50% Human Human -DTXSID0047662 Css NA 1.421 mg/L 3compartmentss NA 95% Human Human -DTXSID0047662 Css NA 0.1148 mg/L PBTK NA 50% Human Human -DTXSID0047662 Css NA 0.8735 mg/L PBTK NA 95% Human Human -DTXSID0047662 Clint NA 54.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047662 Fup NA 0.0694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047662 Vd NA 0.7998 L/kg 1compartment NA NA Rat Human +DTXSID0047662 TK.Half.Life NA 4.885 hours 1compartment NA NA Human Human +DTXSID0047662 Css NA 0.2272 mg/L 3compartmentss NA 50% Human Human +DTXSID0047662 Css NA 1.571 mg/L 3compartmentss NA 95% Human Human +DTXSID0047662 Css NA 0.1583 mg/L PBTK NA 50% Human Human +DTXSID0047662 Css NA 1.045 mg/L PBTK NA 95% Human Human +DTXSID0047662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047662 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047662 Vd NA 1.517 L/kg 1compartment NA NA Rat Human DTXSID0047662 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047662 TK.Half.Life NA 0.8171 hours 1compartment NA NA Rat Human -DTXSID0047662 Css NA 0.1038 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047662 Css NA 0.6415 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047662 Css NA 0.06174 mg/L PBTK NA 50% Rat Human -DTXSID0047662 Css NA 0.3638 mg/L PBTK NA 95% Rat Human -DTXSID0047745 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047745 Fup NA 0.6582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047745 Vd NA 1.64 L/kg 1compartment NA NA Human Human +DTXSID0047662 TK.Half.Life NA 1.644 hours 1compartment NA NA Rat Human +DTXSID0047662 Css NA 0.02872 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047662 Css NA 0.1594 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047662 Css NA 0.01974 mg/L PBTK NA 50% Rat Human +DTXSID0047662 Css NA 0.1045 mg/L PBTK NA 95% Rat Human +DTXSID0047745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047745 Fup 0.37 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047745 Vd NA 1.205 L/kg 1compartment NA NA Human Human DTXSID0047745 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047745 TK.Half.Life NA 2.463 hours 1compartment NA NA Human Human -DTXSID0047745 Css NA 0.1078 mg/L 3compartmentss NA 50% Human Human -DTXSID0047745 Css NA 0.9936 mg/L 3compartmentss NA 95% Human Human -DTXSID0047745 Css NA 0.09521 mg/L PBTK NA 50% Human Human -DTXSID0047745 Css NA 0.6872 mg/L PBTK NA 95% Human Human -DTXSID0047745 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047745 Fup NA 0.6582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047745 Vd NA 1.403 L/kg 1compartment NA NA Rat Human +DTXSID0047745 TK.Half.Life NA 1.416 hours 1compartment NA NA Human Human +DTXSID0047745 Css NA 0.0545 mg/L 3compartmentss NA 50% Human Human +DTXSID0047745 Css NA 0.414 mg/L 3compartmentss NA 95% Human Human +DTXSID0047745 Css NA 0.04236 mg/L PBTK NA 50% Human Human +DTXSID0047745 Css NA 0.2937 mg/L PBTK NA 95% Human Human +DTXSID0047745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047745 Fup 0.37 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047745 Vd NA 1.024 L/kg 1compartment NA NA Rat Human DTXSID0047745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047745 TK.Half.Life NA 1.03 hours 1compartment NA NA Rat Human -DTXSID0047745 Css NA 0.05238 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047745 Css NA 0.373 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047745 Css NA 0.04572 mg/L PBTK NA 50% Rat Human -DTXSID0047745 Css NA 0.2447 mg/L PBTK NA 95% Rat Human -DTXSID0047797 Clint NA 3.181 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047797 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047797 Vd NA 1.264 L/kg 1compartment NA NA Human Human +DTXSID0047745 TK.Half.Life NA 0.6043 hours 1compartment NA NA Rat Human +DTXSID0047745 Css NA 0.006783 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047745 Css NA 0.04083 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047745 Css NA 0.00529 mg/L PBTK NA 50% Rat Human +DTXSID0047745 Css NA 0.02833 mg/L PBTK NA 95% Rat Human +DTXSID0047797 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047797 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047797 Vd NA 0.4563 L/kg 1compartment NA NA Human Human DTXSID0047797 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047797 TK.Half.Life NA 8.821 hours 1compartment NA NA Human Human -DTXSID0047797 Css NA 0.8006 mg/L 3compartmentss NA 50% Human Human -DTXSID0047797 Css NA 4.5 mg/L 3compartmentss NA 95% Human Human -DTXSID0047797 Css NA 0.5828 mg/L PBTK NA 50% Human Human -DTXSID0047797 Css NA 2.96 mg/L PBTK NA 95% Human Human -DTXSID0047797 Clint NA 3.181 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047797 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047797 Vd NA 1.152 L/kg 1compartment NA NA Rat Human +DTXSID0047797 TK.Half.Life NA 1.808 hours 1compartment NA NA Human Human +DTXSID0047797 Css NA 0.2298 mg/L 3compartmentss NA 50% Human Human +DTXSID0047797 Css NA 1.441 mg/L 3compartmentss NA 95% Human Human +DTXSID0047797 Css NA 0.1489 mg/L PBTK NA 50% Human Human +DTXSID0047797 Css NA 0.8872 mg/L PBTK NA 95% Human Human +DTXSID0047797 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047797 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047797 Vd NA 0.4153 L/kg 1compartment NA NA Rat Human DTXSID0047797 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047797 TK.Half.Life NA 4.446 hours 1compartment NA NA Rat Human -DTXSID0047797 Css NA 0.3882 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047797 Css NA 1.614 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047797 Css NA 0.2684 mg/L PBTK NA 50% Rat Human -DTXSID0047797 Css NA 0.9716 mg/L PBTK NA 95% Rat Human -DTXSID0047799 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047799 Fup NA 0.0149 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047799 Vd NA 47.56 L/kg 1compartment NA NA Human Human -DTXSID0047799 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID0047799 TK.Half.Life NA 1375000 hours 1compartment NA NA Human Human -DTXSID0047799 Css NA 440.7 mg/L 3compartmentss NA 50% Human Human -DTXSID0047799 Css NA 1676 mg/L 3compartmentss NA 95% Human Human -DTXSID0047799 Css NA 2308 mg/L PBTK NA 50% Human Human -DTXSID0047799 Css NA 5594 mg/L PBTK NA 95% Human Human -DTXSID0047799 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047799 Fup NA 0.0149 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047799 Vd NA 40.02 L/kg 1compartment NA NA Rat Human -DTXSID0047799 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID0047799 TK.Half.Life NA 98440 hours 1compartment NA NA Rat Human -DTXSID0047799 Css NA 106 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047799 Css NA 400.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047799 Css NA 600.2 mg/L PBTK NA 50% Rat Human -DTXSID0047799 Css NA 1223 mg/L PBTK NA 95% Rat Human -DTXSID0047820 Clint NA 38.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047820 Fup NA 0.1987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047820 Vd NA 2.726 L/kg 1compartment NA NA Human Human +DTXSID0047797 TK.Half.Life NA 0.9677 hours 1compartment NA NA Rat Human +DTXSID0047797 Css NA 0.002242 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047797 Css NA 0.01229 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047797 Css NA 0.001382 mg/L PBTK NA 50% Rat Human +DTXSID0047797 Css NA 0.007176 mg/L PBTK NA 95% Rat Human +DTXSID0047799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047799 Fup 0.0143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047799 Vd NA 30.19 L/kg 1compartment NA NA Human Human +DTXSID0047799 Days.Css NA 203 Days PBTK NA NA Human Human +DTXSID0047799 TK.Half.Life NA 850.7 hours 1compartment NA NA Human Human +DTXSID0047799 Css NA 0.4156 mg/L 3compartmentss NA 50% Human Human +DTXSID0047799 Css NA 3.234 mg/L 3compartmentss NA 95% Human Human +DTXSID0047799 Css NA 1.314 mg/L PBTK NA 50% Human Human +DTXSID0047799 Css NA 8.389 mg/L PBTK NA 95% Human Human +DTXSID0047799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047799 Fup 0.0143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047799 Vd NA 24.95 L/kg 1compartment NA NA Rat Human +DTXSID0047799 Days.Css NA 125 Days PBTK NA NA Rat Human +DTXSID0047799 TK.Half.Life NA 124.5 hours 1compartment NA NA Rat Human +DTXSID0047799 Css NA 0.004102 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047799 Css NA 0.02851 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047799 Css NA 0.01366 mg/L PBTK NA 50% Rat Human +DTXSID0047799 Css NA 0.08544 mg/L PBTK NA 95% Rat Human +DTXSID0047820 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047820 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047820 Vd NA 2.032 L/kg 1compartment NA NA Human Human DTXSID0047820 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047820 TK.Half.Life NA 2.331 hours 1compartment NA NA Human Human -DTXSID0047820 Css NA 0.03009 mg/L 3compartmentss NA 50% Human Human -DTXSID0047820 Css NA 0.2553 mg/L 3compartmentss NA 95% Human Human -DTXSID0047820 Css NA 0.03226 mg/L PBTK NA 50% Human Human -DTXSID0047820 Css NA 0.2234 mg/L PBTK NA 95% Human Human -DTXSID0047820 Clint NA 38.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047820 Fup NA 0.1987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047820 Vd NA 2.714 L/kg 1compartment NA NA Rat Human +DTXSID0047820 TK.Half.Life NA 2.307 hours 1compartment NA NA Human Human +DTXSID0047820 Css NA 0.05236 mg/L 3compartmentss NA 50% Human Human +DTXSID0047820 Css NA 0.4316 mg/L 3compartmentss NA 95% Human Human +DTXSID0047820 Css NA 0.0494 mg/L PBTK NA 50% Human Human +DTXSID0047820 Css NA 0.3516 mg/L PBTK NA 95% Human Human +DTXSID0047820 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047820 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047820 Vd NA 2.015 L/kg 1compartment NA NA Rat Human DTXSID0047820 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047820 TK.Half.Life NA 1.252 hours 1compartment NA NA Rat Human -DTXSID0047820 Css NA 0.01616 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047820 Css NA 0.1099 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047820 Css NA 0.01726 mg/L PBTK NA 50% Rat Human -DTXSID0047820 Css NA 0.09633 mg/L PBTK NA 95% Rat Human -DTXSID0047822 Clint NA 16.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047822 Fup NA 0.6844 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047822 Vd NA 2.865 L/kg 1compartment NA NA Human Human +DTXSID0047820 TK.Half.Life NA 1.272 hours 1compartment NA NA Rat Human +DTXSID0047820 Css NA 0.006462 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047820 Css NA 0.04023 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047820 Css NA 0.006278 mg/L PBTK NA 50% Rat Human +DTXSID0047820 Css NA 0.03252 mg/L PBTK NA 95% Rat Human +DTXSID0047822 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047822 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047822 Vd NA 2.481 L/kg 1compartment NA NA Human Human DTXSID0047822 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047822 TK.Half.Life NA 2.212 hours 1compartment NA NA Human Human -DTXSID0047822 Css NA 0.03167 mg/L 3compartmentss NA 50% Human Human -DTXSID0047822 Css NA 0.3718 mg/L 3compartmentss NA 95% Human Human -DTXSID0047822 Css NA 0.03454 mg/L PBTK NA 50% Human Human -DTXSID0047822 Css NA 0.2913 mg/L PBTK NA 95% Human Human -DTXSID0047822 Clint NA 16.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047822 Fup NA 0.6844 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047822 Vd NA 2.834 L/kg 1compartment NA NA Rat Human +DTXSID0047822 TK.Half.Life NA 2.203 hours 1compartment NA NA Human Human +DTXSID0047822 Css NA 0.0328 mg/L 3compartmentss NA 50% Human Human +DTXSID0047822 Css NA 0.3191 mg/L 3compartmentss NA 95% Human Human +DTXSID0047822 Css NA 0.03296 mg/L PBTK NA 50% Human Human +DTXSID0047822 Css NA 0.252 mg/L PBTK NA 95% Human Human +DTXSID0047822 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047822 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047822 Vd NA 2.416 L/kg 1compartment NA NA Rat Human DTXSID0047822 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047822 TK.Half.Life NA 1.111 hours 1compartment NA NA Rat Human -DTXSID0047822 Css NA 0.01565 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047822 Css NA 0.1693 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047822 Css NA 0.01747 mg/L PBTK NA 50% Rat Human -DTXSID0047822 Css NA 0.1213 mg/L PBTK NA 95% Rat Human -DTXSID0047828 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047828 Fup NA 0.2162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047828 Vd NA 3.618 L/kg 1compartment NA NA Human Human +DTXSID0047822 TK.Half.Life NA 1.092 hours 1compartment NA NA Rat Human +DTXSID0047822 Css NA 0.003956 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047822 Css NA 0.03081 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047822 Css NA 0.004083 mg/L PBTK NA 50% Rat Human +DTXSID0047822 Css NA 0.02478 mg/L PBTK NA 95% Rat Human +DTXSID0047828 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047828 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047828 Vd NA 1.353 L/kg 1compartment NA NA Human Human DTXSID0047828 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047828 TK.Half.Life NA 5.94 hours 1compartment NA NA Human Human -DTXSID0047828 Css NA 0.09346 mg/L 3compartmentss NA 50% Human Human -DTXSID0047828 Css NA 0.7045 mg/L 3compartmentss NA 95% Human Human -DTXSID0047828 Css NA 0.1076 mg/L PBTK NA 50% Human Human -DTXSID0047828 Css NA 0.6536 mg/L PBTK NA 95% Human Human -DTXSID0047828 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047828 Fup NA 0.2162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047828 Vd NA 3.64 L/kg 1compartment NA NA Rat Human +DTXSID0047828 TK.Half.Life NA 2.992 hours 1compartment NA NA Human Human +DTXSID0047828 Css NA 0.1684 mg/L 3compartmentss NA 50% Human Human +DTXSID0047828 Css NA 1.131 mg/L 3compartmentss NA 95% Human Human +DTXSID0047828 Css NA 0.1388 mg/L PBTK NA 50% Human Human +DTXSID0047828 Css NA 0.806 mg/L PBTK NA 95% Human Human +DTXSID0047828 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047828 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047828 Vd NA 1.357 L/kg 1compartment NA NA Rat Human DTXSID0047828 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047828 TK.Half.Life NA 3.466 hours 1compartment NA NA Rat Human -DTXSID0047828 Css NA 0.04782 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047828 Css NA 0.2782 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047828 Css NA 0.05509 mg/L PBTK NA 50% Rat Human -DTXSID0047828 Css NA 0.2493 mg/L PBTK NA 95% Rat Human -DTXSID0047872 Clint NA 23.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047872 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047872 Vd NA 1.238 L/kg 1compartment NA NA Human Human -DTXSID0047872 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047872 TK.Half.Life NA 0.8267 hours 1compartment NA NA Human Human -DTXSID0047872 Css NA 0.02048 mg/L 3compartmentss NA 50% Human Human -DTXSID0047872 Css NA 0.2741 mg/L 3compartmentss NA 95% Human Human -DTXSID0047872 Css NA 0.01827 mg/L PBTK NA 50% Human Human -DTXSID0047872 Css NA 0.2141 mg/L PBTK NA 95% Human Human -DTXSID0047872 Clint NA 23.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047872 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047872 Vd NA 1.156 L/kg 1compartment NA NA Rat Human +DTXSID0047828 TK.Half.Life NA 1.723 hours 1compartment NA NA Rat Human +DTXSID0047828 Css NA 0.0197 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047828 Css NA 0.09932 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047828 Css NA 0.01648 mg/L PBTK NA 50% Rat Human +DTXSID0047828 Css NA 0.06865 mg/L PBTK NA 95% Rat Human +DTXSID0047872 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047872 Fup 0.73 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047872 Vd NA 1.116 L/kg 1compartment NA NA Human Human +DTXSID0047872 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0047872 TK.Half.Life NA 10.55 hours 1compartment NA NA Human Human +DTXSID0047872 Css NA 1.001 mg/L 3compartmentss NA 50% Human Human +DTXSID0047872 Css NA 6.734 mg/L 3compartmentss NA 95% Human Human +DTXSID0047872 Css NA 0.8637 mg/L PBTK NA 50% Human Human +DTXSID0047872 Css NA 4.364 mg/L PBTK NA 95% Human Human +DTXSID0047872 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047872 Fup 0.73 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047872 Vd NA 1.021 L/kg 1compartment NA NA Rat Human DTXSID0047872 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047872 TK.Half.Life NA 0.3623 hours 1compartment NA NA Rat Human -DTXSID0047872 Css NA 0.01019 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047872 Css NA 0.1053 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047872 Css NA 0.009098 mg/L PBTK NA 50% Rat Human -DTXSID0047872 Css NA 0.07744 mg/L PBTK NA 95% Rat Human -DTXSID0047876 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047876 Fup NA 0.1039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047876 Vd NA 1.394 L/kg 1compartment NA NA Human Human -DTXSID0047876 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID0047876 TK.Half.Life NA 114.1 hours 1compartment NA NA Human Human -DTXSID0047876 Css NA 11.63 mg/L 3compartmentss NA 50% Human Human -DTXSID0047876 Css NA 48.54 mg/L 3compartmentss NA 95% Human Human -DTXSID0047876 Css NA 7.696 mg/L PBTK NA 50% Human Human -DTXSID0047876 Css NA 29.73 mg/L PBTK NA 95% Human Human -DTXSID0047876 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047876 Fup NA 0.1039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047876 Vd NA 1.073 L/kg 1compartment NA NA Rat Human -DTXSID0047876 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID0047876 TK.Half.Life NA 24.48 hours 1compartment NA NA Rat Human -DTXSID0047876 Css NA 3.223 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047876 Css NA 11.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047876 Css NA 2.015 mg/L PBTK NA 50% Rat Human -DTXSID0047876 Css NA 6.548 mg/L PBTK NA 95% Rat Human -DTXSID0047878 Clint NA 120.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047878 Fup NA 0.6864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047878 Vd NA 1.367 L/kg 1compartment NA NA Human Human -DTXSID0047878 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047878 TK.Half.Life NA 0.8275 hours 1compartment NA NA Human Human -DTXSID0047878 Css NA 0.005469 mg/L 3compartmentss NA 50% Human Human -DTXSID0047878 Css NA 0.06329 mg/L 3compartmentss NA 95% Human Human -DTXSID0047878 Css NA 0.004856 mg/L PBTK NA 50% Human Human -DTXSID0047878 Css NA 0.04508 mg/L PBTK NA 95% Human Human -DTXSID0047878 Clint NA 120.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047878 Fup NA 0.6864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047878 Vd NA 1.332 L/kg 1compartment NA NA Rat Human +DTXSID0047872 TK.Half.Life NA 3.132 hours 1compartment NA NA Rat Human +DTXSID0047872 Css NA 0.06008 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047872 Css NA 0.3833 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047872 Css NA 0.05199 mg/L PBTK NA 50% Rat Human +DTXSID0047872 Css NA 0.2398 mg/L PBTK NA 95% Rat Human +DTXSID0047874 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047874 Fup 0.00585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047874 Vd NA 3.07 L/kg 1compartment NA NA Human Human +DTXSID0047874 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID0047874 TK.Half.Life NA 91.37 hours 1compartment NA NA Human Human +DTXSID0047874 Css NA 3.59 mg/L 3compartmentss NA 50% Human Human +DTXSID0047874 Css NA 22.28 mg/L 3compartmentss NA 95% Human Human +DTXSID0047874 Css NA 2.46 mg/L PBTK NA 50% Human Human +DTXSID0047874 Css NA 15 mg/L PBTK NA 95% Human Human +DTXSID0047874 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047874 Fup 0.00585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047874 Vd NA 2.298 L/kg 1compartment NA NA Rat Human +DTXSID0047874 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID0047874 TK.Half.Life NA 13.14 hours 1compartment NA NA Rat Human +DTXSID0047874 Css NA 0.4716 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047874 Css NA 2.48 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047874 Css NA 0.3212 mg/L PBTK NA 50% Rat Human +DTXSID0047874 Css NA 1.688 mg/L PBTK NA 95% Rat Human +DTXSID0047876 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047876 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047876 Vd NA 2.199 L/kg 1compartment NA NA Human Human +DTXSID0047876 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0047876 TK.Half.Life NA 6.627 hours 1compartment NA NA Human Human +DTXSID0047876 Css NA 0.2985 mg/L 3compartmentss NA 50% Human Human +DTXSID0047876 Css NA 2.093 mg/L 3compartmentss NA 95% Human Human +DTXSID0047876 Css NA 0.207 mg/L PBTK NA 50% Human Human +DTXSID0047876 Css NA 1.383 mg/L PBTK NA 95% Human Human +DTXSID0047876 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047876 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047876 Vd NA 1.669 L/kg 1compartment NA NA Rat Human +DTXSID0047876 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0047876 TK.Half.Life NA 2.055 hours 1compartment NA NA Rat Human +DTXSID0047876 Css NA 0.03446 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047876 Css NA 0.192 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047876 Css NA 0.02362 mg/L PBTK NA 50% Rat Human +DTXSID0047876 Css NA 0.1239 mg/L PBTK NA 95% Rat Human +DTXSID0047878 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047878 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047878 Vd NA 0.987 L/kg 1compartment NA NA Human Human +DTXSID0047878 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0047878 TK.Half.Life NA 15.06 hours 1compartment NA NA Human Human +DTXSID0047878 Css NA 1.547 mg/L 3compartmentss NA 50% Human Human +DTXSID0047878 Css NA 7.144 mg/L 3compartmentss NA 95% Human Human +DTXSID0047878 Css NA 1.239 mg/L PBTK NA 50% Human Human +DTXSID0047878 Css NA 4.696 mg/L PBTK NA 95% Human Human +DTXSID0047878 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047878 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047878 Vd NA 0.9617 L/kg 1compartment NA NA Rat Human DTXSID0047878 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047878 TK.Half.Life NA 0.3605 hours 1compartment NA NA Rat Human -DTXSID0047878 Css NA 0.002842 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047878 Css NA 0.0302 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047878 Css NA 0.0025 mg/L PBTK NA 50% Rat Human -DTXSID0047878 Css NA 0.02101 mg/L PBTK NA 95% Rat Human +DTXSID0047878 TK.Half.Life NA 4.937 hours 1compartment NA NA Rat Human +DTXSID0047878 Css NA 0.09776 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047878 Css NA 0.4003 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047878 Css NA 0.07778 mg/L PBTK NA 50% Rat Human +DTXSID0047878 Css NA 0.253 mg/L PBTK NA 95% Rat Human DTXSID0047901 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0047901 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047901 Vd NA 0.4495 L/kg 1compartment NA NA Human Human -DTXSID0047901 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0047901 TK.Half.Life NA 9.523 hours 1compartment NA NA Human Human -DTXSID0047901 Css NA 2.472 mg/L 3compartmentss NA 50% Human Human -DTXSID0047901 Css NA 9.973 mg/L 3compartmentss NA 95% Human Human -DTXSID0047901 Css NA 1.734 mg/L PBTK NA 50% Human Human -DTXSID0047901 Css NA 6.209 mg/L PBTK NA 95% Human Human +DTXSID0047901 Vd NA 0.8767 L/kg 1compartment NA NA Human Human +DTXSID0047901 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0047901 TK.Half.Life NA 18.57 hours 1compartment NA NA Human Human +DTXSID0047901 Css NA 1.926 mg/L 3compartmentss NA 50% Human Human +DTXSID0047901 Css NA 8.073 mg/L 3compartmentss NA 95% Human Human +DTXSID0047901 Css NA 1.48 mg/L PBTK NA 50% Human Human +DTXSID0047901 Css NA 5.281 mg/L PBTK NA 95% Human Human DTXSID0047901 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0047901 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047901 Vd NA 0.4613 L/kg 1compartment NA NA Rat Human +DTXSID0047901 Vd NA 0.8691 L/kg 1compartment NA NA Rat Human DTXSID0047901 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047901 TK.Half.Life NA 3.331 hours 1compartment NA NA Rat Human -DTXSID0047901 Css NA 0.691 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047901 Css NA 2.255 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047901 Css NA 0.4587 mg/L PBTK NA 50% Rat Human -DTXSID0047901 Css NA 1.315 mg/L PBTK NA 95% Rat Human +DTXSID0047901 TK.Half.Life NA 6.273 hours 1compartment NA NA Rat Human +DTXSID0047901 Css NA 0.03487 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047901 Css NA 0.2179 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047901 Css NA 0.02562 mg/L PBTK NA 50% Rat Human +DTXSID0047901 Css NA 0.1423 mg/L PBTK NA 95% Rat Human DTXSID0047903 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0047903 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047903 Vd NA 0.4495 L/kg 1compartment NA NA Human Human -DTXSID0047903 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0047903 TK.Half.Life NA 9.523 hours 1compartment NA NA Human Human -DTXSID0047903 Css NA 2.472 mg/L 3compartmentss NA 50% Human Human -DTXSID0047903 Css NA 9.973 mg/L 3compartmentss NA 95% Human Human -DTXSID0047903 Css NA 1.734 mg/L PBTK NA 50% Human Human -DTXSID0047903 Css NA 6.209 mg/L PBTK NA 95% Human Human +DTXSID0047903 Vd NA 1.039 L/kg 1compartment NA NA Human Human +DTXSID0047903 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0047903 TK.Half.Life NA 22.01 hours 1compartment NA NA Human Human +DTXSID0047903 Css NA 1.877 mg/L 3compartmentss NA 50% Human Human +DTXSID0047903 Css NA 7.992 mg/L 3compartmentss NA 95% Human Human +DTXSID0047903 Css NA 1.48 mg/L PBTK NA 50% Human Human +DTXSID0047903 Css NA 5.281 mg/L PBTK NA 95% Human Human DTXSID0047903 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0047903 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047903 Vd NA 0.4613 L/kg 1compartment NA NA Rat Human +DTXSID0047903 Vd NA 1.042 L/kg 1compartment NA NA Rat Human DTXSID0047903 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047903 TK.Half.Life NA 3.331 hours 1compartment NA NA Rat Human -DTXSID0047903 Css NA 0.691 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047903 Css NA 2.255 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047903 Css NA 0.4587 mg/L PBTK NA 50% Rat Human -DTXSID0047903 Css NA 1.315 mg/L PBTK NA 95% Rat Human -DTXSID0047905 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047905 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047905 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID0047905 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0047905 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID0047905 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID0047905 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID0047905 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID0047905 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID0047905 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047905 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047905 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID0047905 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047905 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID0047905 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047905 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047905 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID0047905 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID0047953 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047953 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047953 Vd NA 478.8 L/kg 1compartment NA NA Human Human -DTXSID0047953 Days.Css NA 96 Days PBTK NA NA Human Human -DTXSID0047953 TK.Half.Life NA 455.4 hours 1compartment NA NA Human Human -DTXSID0047953 Css NA 0.001119 mg/L 3compartmentss NA 50% Human Human -DTXSID0047953 Css NA 0.00673 mg/L 3compartmentss NA 95% Human Human -DTXSID0047953 Css NA 0.07869 mg/L PBTK NA 50% Human Human -DTXSID0047953 Css NA 0.4336 mg/L PBTK NA 95% Human Human -DTXSID0047953 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047953 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047953 Vd NA 432.2 L/kg 1compartment NA NA Rat Human -DTXSID0047953 Days.Css NA 70 Days PBTK NA NA Rat Human -DTXSID0047953 TK.Half.Life NA 76.25 hours 1compartment NA NA Rat Human -DTXSID0047953 Css NA 0.0005635 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047953 Css NA 0.002513 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047953 Css NA 0.04275 mg/L PBTK NA 50% Rat Human -DTXSID0047953 Css NA 0.1912 mg/L PBTK NA 95% Rat Human -DTXSID0047955 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047955 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047955 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID0047955 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0047955 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID0047955 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID0047955 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID0047955 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID0047955 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID0047955 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047955 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047955 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID0047955 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047955 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID0047955 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047955 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047955 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID0047955 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID0047957 Clint NA 81.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047957 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0047957 Vd NA 2.174 L/kg 1compartment NA NA Human Human -DTXSID0047957 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0047957 TK.Half.Life NA 7.828 hours 1compartment NA NA Human Human -DTXSID0047957 Css NA 0.4445 mg/L 3compartmentss NA 50% Human Human -DTXSID0047957 Css NA 3.546 mg/L 3compartmentss NA 95% Human Human -DTXSID0047957 Css NA 0.2875 mg/L PBTK NA 50% Human Human -DTXSID0047957 Css NA 2.2 mg/L PBTK NA 95% Human Human -DTXSID0047957 Clint NA 81.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047957 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0047957 Vd NA 1.616 L/kg 1compartment NA NA Rat Human -DTXSID0047957 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0047957 TK.Half.Life NA 2.378 hours 1compartment NA NA Rat Human -DTXSID0047957 Css NA 0.2483 mg/L 3compartmentss NA 50% Rat Human -DTXSID0047957 Css NA 1.679 mg/L 3compartmentss NA 95% Rat Human -DTXSID0047957 Css NA 0.1526 mg/L PBTK NA 50% Rat Human -DTXSID0047957 Css NA 0.987 mg/L PBTK NA 95% Rat Human +DTXSID0047903 TK.Half.Life NA 7.523 hours 1compartment NA NA Rat Human +DTXSID0047903 Css NA 0.03396 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047903 Css NA 0.2153 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047903 Css NA 0.02562 mg/L PBTK NA 50% Rat Human +DTXSID0047903 Css NA 0.1423 mg/L PBTK NA 95% Rat Human +DTXSID0047957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047957 Fup 0.02 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0047957 Vd NA 2.448 L/kg 1compartment NA NA Human Human +DTXSID0047957 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0047957 TK.Half.Life NA 29.66 hours 1compartment NA NA Human Human +DTXSID0047957 Css NA 1.696 mg/L 3compartmentss NA 50% Human Human +DTXSID0047957 Css NA 12.73 mg/L 3compartmentss NA 95% Human Human +DTXSID0047957 Css NA 1.12 mg/L PBTK NA 50% Human Human +DTXSID0047957 Css NA 8.107 mg/L PBTK NA 95% Human Human +DTXSID0047957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047957 Fup 0.02 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0047957 Vd NA 1.825 L/kg 1compartment NA NA Rat Human +DTXSID0047957 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0047957 TK.Half.Life NA 7.556 hours 1compartment NA NA Rat Human +DTXSID0047957 Css NA 0.2176 mg/L 3compartmentss NA 50% Rat Human +DTXSID0047957 Css NA 1.375 mg/L 3compartmentss NA 95% Rat Human +DTXSID0047957 Css NA 0.1407 mg/L PBTK NA 50% Rat Human +DTXSID0047957 Css NA 0.8588 mg/L PBTK NA 95% Rat Human DTXSID0048181 Clint 10.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0048181 Fup 0.155 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0048181 Vd NA 1.793 L/kg 1compartment NA NA Human Human DTXSID0048181 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID0048181 TK.Half.Life NA 6.608 hours 1compartment NA NA Human Human -DTXSID0048181 Css NA 0.3538 mg/L 3compartmentss NA 50% Human Human -DTXSID0048181 Css NA 2.039 mg/L 3compartmentss NA 95% Human Human -DTXSID0048181 Css NA 0.2503 mg/L PBTK NA 50% Human Human -DTXSID0048181 Css NA 1.378 mg/L PBTK NA 95% Human Human +DTXSID0048181 Css NA 0.3472 mg/L 3compartmentss NA 50% Human Human +DTXSID0048181 Css NA 1.95 mg/L 3compartmentss NA 95% Human Human +DTXSID0048181 Css NA 0.2465 mg/L PBTK NA 50% Human Human +DTXSID0048181 Css NA 1.313 mg/L PBTK NA 95% Human Human DTXSID0048181 Clint 10.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0048181 Fup 0.155 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0048181 Vd NA 1.387 L/kg 1compartment NA NA Rat Human DTXSID0048181 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0048181 TK.Half.Life NA 2.4 hours 1compartment NA NA Rat Human -DTXSID0048181 Css NA 0.1909 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048181 Css NA 0.7842 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048181 Css NA 0.1288 mg/L PBTK NA 50% Rat Human -DTXSID0048181 Css NA 0.5175 mg/L PBTK NA 95% Rat Human +DTXSID0048181 Css NA 0.04325 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048181 Css NA 0.1758 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048181 Css NA 0.0303 mg/L PBTK NA 50% Rat Human +DTXSID0048181 Css NA 0.1196 mg/L PBTK NA 95% Rat Human DTXSID0048183 Clint 139 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0048183 Fup 0.0121 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0048183 Vd NA 0.5783 L/kg 1compartment NA NA Human Human +DTXSID0048183 Vd NA 0.5725 L/kg 1compartment NA NA Human Human DTXSID0048183 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048183 TK.Half.Life NA 1.723 hours 1compartment NA NA Human Human -DTXSID0048183 Css NA 0.3036 mg/L 3compartmentss NA 50% Human Human -DTXSID0048183 Css NA 2.798 mg/L 3compartmentss NA 95% Human Human -DTXSID0048183 Css NA 0.1819 mg/L PBTK NA 50% Human Human -DTXSID0048183 Css NA 1.625 mg/L PBTK NA 95% Human Human +DTXSID0048183 TK.Half.Life NA 1.706 hours 1compartment NA NA Human Human +DTXSID0048183 Css NA 0.2956 mg/L 3compartmentss NA 50% Human Human +DTXSID0048183 Css NA 2.986 mg/L 3compartmentss NA 95% Human Human +DTXSID0048183 Css NA 0.1772 mg/L PBTK NA 50% Human Human +DTXSID0048183 Css NA 1.761 mg/L PBTK NA 95% Human Human DTXSID0048183 Clint 139 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0048183 Fup 0.0121 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0048183 Vd NA 0.4391 L/kg 1compartment NA NA Rat Human +DTXSID0048183 Vd NA 0.4352 L/kg 1compartment NA NA Rat Human DTXSID0048183 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048183 TK.Half.Life NA 0.7784 hours 1compartment NA NA Rat Human -DTXSID0048183 Css NA 0.1771 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048183 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048183 Css NA 0.09877 mg/L PBTK NA 50% Rat Human -DTXSID0048183 Css NA 0.7297 mg/L PBTK NA 95% Rat Human +DTXSID0048183 TK.Half.Life NA 0.7729 hours 1compartment NA NA Rat Human +DTXSID0048183 Css NA 0.04058 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048183 Css NA 0.316 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048183 Css NA 0.02342 mg/L PBTK NA 50% Rat Human +DTXSID0048183 Css NA 0.1804 mg/L PBTK NA 95% Rat Human DTXSID0048185 Clint 17.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0048185 Fup 0.0723 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0048185 Vd NA 0.9243 L/kg 1compartment NA NA Human Human +DTXSID0048185 Vd NA 1.304 L/kg 1compartment NA NA Human Human DTXSID0048185 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048185 TK.Half.Life NA 3.508 hours 1compartment NA NA Human Human -DTXSID0048185 Css NA 0.4022 mg/L 3compartmentss NA 50% Human Human -DTXSID0048185 Css NA 2.933 mg/L 3compartmentss NA 95% Human Human -DTXSID0048185 Css NA 0.2621 mg/L PBTK NA 50% Human Human -DTXSID0048185 Css NA 1.834 mg/L PBTK NA 95% Human Human +DTXSID0048185 TK.Half.Life NA 5.311 hours 1compartment NA NA Human Human +DTXSID0048185 Css NA 0.4185 mg/L 3compartmentss NA 50% Human Human +DTXSID0048185 Css NA 3.053 mg/L 3compartmentss NA 95% Human Human +DTXSID0048185 Css NA 0.2744 mg/L PBTK NA 50% Human Human +DTXSID0048185 Css NA 1.895 mg/L PBTK NA 95% Human Human DTXSID0048185 Clint 17.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0048185 Fup 0.0723 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0048185 Vd NA 0.7729 L/kg 1compartment NA NA Rat Human +DTXSID0048185 Vd NA 0.994 L/kg 1compartment NA NA Rat Human DTXSID0048185 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048185 TK.Half.Life NA 1.732 hours 1compartment NA NA Rat Human -DTXSID0048185 Css NA 0.2238 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048185 Css NA 1.273 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048185 Css NA 0.1384 mg/L PBTK NA 50% Rat Human -DTXSID0048185 Css NA 0.7587 mg/L PBTK NA 95% Rat Human +DTXSID0048185 TK.Half.Life NA 2.169 hours 1compartment NA NA Rat Human +DTXSID0048185 Css NA 0.05456 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048185 Css NA 0.2985 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048185 Css NA 0.03549 mg/L PBTK NA 50% Rat Human +DTXSID0048185 Css NA 0.1849 mg/L PBTK NA 95% Rat Human DTXSID0048189 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0048189 Fup 2.2e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0048189 Vd NA 0.2489 L/kg 1compartment NA NA Human Human +DTXSID0048189 Vd NA 0.2401 L/kg 1compartment NA NA Human Human DTXSID0048189 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID0048189 TK.Half.Life NA 16110 hours 1compartment NA NA Human Human -DTXSID0048189 Css NA 4820 mg/L 3compartmentss NA 50% Human Human -DTXSID0048189 Css NA 13700 mg/L 3compartmentss NA 95% Human Human -DTXSID0048189 Css NA 2874 mg/L PBTK NA 50% Human Human -DTXSID0048189 Css NA 7774 mg/L PBTK NA 95% Human Human +DTXSID0048189 TK.Half.Life NA 15540 hours 1compartment NA NA Human Human +DTXSID0048189 Css NA 3970 mg/L 3compartmentss NA 50% Human Human +DTXSID0048189 Css NA 12180 mg/L 3compartmentss NA 95% Human Human +DTXSID0048189 Css NA 2346 mg/L PBTK NA 50% Human Human +DTXSID0048189 Css NA 6942 mg/L PBTK NA 95% Human Human DTXSID0048189 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0048189 Fup 2.2e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0048189 Vd NA 0.2065 L/kg 1compartment NA NA Rat Human -DTXSID0048189 Days.Css NA 1250 Days PBTK NA NA Rat Human -DTXSID0048189 TK.Half.Life NA 4551 hours 1compartment NA NA Rat Human -DTXSID0048189 Css NA 1800 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048189 Css NA 2449 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048189 Css NA 974.8 mg/L PBTK NA 50% Rat Human -DTXSID0048189 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID0048210 Clint NA 25.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048210 Fup NA 0.0531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048210 Vd NA 2.298 L/kg 1compartment NA NA Human Human -DTXSID0048210 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048210 TK.Half.Life NA 12.03 hours 1compartment NA NA Human Human -DTXSID0048210 Css NA 0.6708 mg/L 3compartmentss NA 50% Human Human -DTXSID0048210 Css NA 4.675 mg/L 3compartmentss NA 95% Human Human -DTXSID0048210 Css NA 0.4478 mg/L PBTK NA 50% Human Human -DTXSID0048210 Css NA 2.933 mg/L PBTK NA 95% Human Human -DTXSID0048210 Clint NA 25.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048210 Fup NA 0.0531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048210 Vd NA 1.722 L/kg 1compartment NA NA Rat Human +DTXSID0048189 Vd NA 0.2014 L/kg 1compartment NA NA Rat Human +DTXSID0048189 Days.Css NA 1221 Days PBTK NA NA Rat Human +DTXSID0048189 TK.Half.Life NA 4440 hours 1compartment NA NA Rat Human +DTXSID0048189 Css NA 70.91 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048189 Css NA 497.9 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048189 Css NA 38.89 mg/L PBTK NA 50% Rat Human +DTXSID0048189 Css NA 278.2 mg/L PBTK NA 95% Rat Human +DTXSID0048210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048210 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048210 Vd NA 1.56 L/kg 1compartment NA NA Human Human +DTXSID0048210 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0048210 TK.Half.Life NA 16.21 hours 1compartment NA NA Human Human +DTXSID0048210 Css NA 1.615 mg/L 3compartmentss NA 50% Human Human +DTXSID0048210 Css NA 14.55 mg/L 3compartmentss NA 95% Human Human +DTXSID0048210 Css NA 1.008 mg/L PBTK NA 50% Human Human +DTXSID0048210 Css NA 8.921 mg/L PBTK NA 95% Human Human +DTXSID0048210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048210 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048210 Vd NA 1.156 L/kg 1compartment NA NA Rat Human DTXSID0048210 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048210 TK.Half.Life NA 3.448 hours 1compartment NA NA Rat Human -DTXSID0048210 Css NA 0.3712 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048210 Css NA 2.093 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048210 Css NA 0.2344 mg/L PBTK NA 50% Rat Human -DTXSID0048210 Css NA 1.288 mg/L PBTK NA 95% Rat Human +DTXSID0048210 TK.Half.Life NA 6.129 hours 1compartment NA NA Rat Human +DTXSID0048210 Css NA 0.2112 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048210 Css NA 1.566 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048210 Css NA 0.1289 mg/L PBTK NA 50% Rat Human +DTXSID0048210 Css NA 0.9162 mg/L PBTK NA 95% Rat Human +DTXSID0048216 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048216 Fup 0.087 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0048216 Vd NA 0.1976 L/kg 1compartment NA NA Human Human +DTXSID0048216 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0048216 TK.Half.Life NA 14.69 hours 1compartment NA NA Human Human +DTXSID0048216 Css NA 6.494 mg/L 3compartmentss NA 50% Human Human +DTXSID0048216 Css NA 31.3 mg/L 3compartmentss NA 95% Human Human +DTXSID0048216 Css NA 3.875 mg/L PBTK NA 50% Human Human +DTXSID0048216 Css NA 18.16 mg/L PBTK NA 95% Human Human +DTXSID0048216 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048216 Fup 0.087 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0048216 Vd NA 0.2008 L/kg 1compartment NA NA Rat Human +DTXSID0048216 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0048216 TK.Half.Life NA 5.089 hours 1compartment NA NA Rat Human +DTXSID0048216 Css NA 0.03592 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048216 Css NA 0.1733 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048216 Css NA 0.02004 mg/L PBTK NA 50% Rat Human +DTXSID0048216 Css NA 0.09506 mg/L PBTK NA 95% Rat Human +DTXSID0048262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048262 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0048262 Vd NA 5.025 L/kg 1compartment NA NA Human Human +DTXSID0048262 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0048262 TK.Half.Life NA 3.118 hours 1compartment NA NA Human Human +DTXSID0048262 Css NA 0.006986 mg/L 3compartmentss NA 50% Human Human +DTXSID0048262 Css NA 0.1387 mg/L 3compartmentss NA 95% Human Human +DTXSID0048262 Css NA 0.01015 mg/L PBTK NA 50% Human Human +DTXSID0048262 Css NA 0.139 mg/L PBTK NA 95% Human Human +DTXSID0048262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048262 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0048262 Vd NA 5.039 L/kg 1compartment NA NA Rat Human +DTXSID0048262 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0048262 TK.Half.Life NA 1.548 hours 1compartment NA NA Rat Human +DTXSID0048262 Css NA 5.634e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048262 Css NA 0.001241 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048262 Css NA 8.353e-05 mg/L PBTK NA 50% Rat Human +DTXSID0048262 Css NA 0.001175 mg/L PBTK NA 95% Rat Human DTXSID0048349 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0048349 Fup NA 0.5459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048349 Vd NA 1.76 L/kg 1compartment NA NA Human Human -DTXSID0048349 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0048349 TK.Half.Life NA 21.5 hours 1compartment NA NA Human Human -DTXSID0048349 Css NA 1.165 mg/L 3compartmentss NA 50% Human Human -DTXSID0048349 Css NA 8.135 mg/L 3compartmentss NA 95% Human Human -DTXSID0048349 Css NA 1.074 mg/L PBTK NA 50% Human Human -DTXSID0048349 Css NA 5.391 mg/L PBTK NA 95% Human Human +DTXSID0048349 Vd NA 0.4149 L/kg 1compartment NA NA Human Human +DTXSID0048349 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0048349 TK.Half.Life NA 4.919 hours 1compartment NA NA Human Human +DTXSID0048349 Css NA 1.244 mg/L 3compartmentss NA 50% Human Human +DTXSID0048349 Css NA 7.541 mg/L 3compartmentss NA 95% Human Human +DTXSID0048349 Css NA 0.884 mg/L PBTK NA 50% Human Human +DTXSID0048349 Css NA 4.686 mg/L PBTK NA 95% Human Human DTXSID0048349 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0048349 Fup NA 0.5459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048349 Vd NA 1.75 L/kg 1compartment NA NA Rat Human +DTXSID0048349 Vd NA 0.429 L/kg 1compartment NA NA Rat Human DTXSID0048349 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048349 TK.Half.Life NA 7.119 hours 1compartment NA NA Rat Human -DTXSID0048349 Css NA 0.3098 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048349 Css NA 1.961 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048349 Css NA 0.2766 mg/L PBTK NA 50% Rat Human -DTXSID0048349 Css NA 1.216 mg/L PBTK NA 95% Rat Human +DTXSID0048349 TK.Half.Life NA 1.733 hours 1compartment NA NA Rat Human +DTXSID0048349 Css NA 0.02386 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048349 Css NA 0.1843 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048349 Css NA 0.0162 mg/L PBTK NA 50% Rat Human +DTXSID0048349 Css NA 0.111 mg/L PBTK NA 95% Rat Human DTXSID0048505 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID0048505 Fup 0.0135 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID0048505 Vd NA 0.9011 L/kg 1compartment NA NA Human Human -DTXSID0048505 Days.Css NA 124 Days PBTK NA NA Human Human -DTXSID0048505 TK.Half.Life NA 494 hours 1compartment NA NA Human Human -DTXSID0048505 Css NA 64.03 mg/L 3compartmentss NA 50% Human Human -DTXSID0048505 Css NA 254.9 mg/L 3compartmentss NA 95% Human Human -DTXSID0048505 Css NA 39.22 mg/L PBTK NA 50% Human Human -DTXSID0048505 Css NA 147.8 mg/L PBTK NA 95% Human Human +DTXSID0048505 Vd NA 0.8715 L/kg 1compartment NA NA Human Human +DTXSID0048505 Days.Css NA 119 Days PBTK NA NA Human Human +DTXSID0048505 TK.Half.Life NA 474.1 hours 1compartment NA NA Human Human +DTXSID0048505 Css NA 61.58 mg/L 3compartmentss NA 50% Human Human +DTXSID0048505 Css NA 247.6 mg/L 3compartmentss NA 95% Human Human +DTXSID0048505 Css NA 37.62 mg/L PBTK NA 50% Human Human +DTXSID0048505 Css NA 144.9 mg/L PBTK NA 95% Human Human DTXSID0048505 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID0048505 Fup 0.0135 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID0048505 Vd NA 0.6705 L/kg 1compartment NA NA Rat Human -DTXSID0048505 Days.Css NA 28 Days PBTK NA NA Rat Human -DTXSID0048505 TK.Half.Life NA 113.3 hours 1compartment NA NA Rat Human -DTXSID0048505 Css NA 17.98 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048505 Css NA 59.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048505 Css NA 10.3 mg/L PBTK NA 50% Rat Human -DTXSID0048505 Css NA 32.87 mg/L PBTK NA 95% Rat Human -DTXSID0048507 Clint NA 112.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048507 Fup NA 0.096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048507 Vd NA 0.5992 L/kg 1compartment NA NA Human Human +DTXSID0048505 Vd NA 0.6482 L/kg 1compartment NA NA Rat Human +DTXSID0048505 Days.Css NA 26 Days PBTK NA NA Rat Human +DTXSID0048505 TK.Half.Life NA 109.3 hours 1compartment NA NA Rat Human +DTXSID0048505 Css NA 3.983 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048505 Css NA 13.48 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048505 Css NA 2.36 mg/L PBTK NA 50% Rat Human +DTXSID0048505 Css NA 7.675 mg/L PBTK NA 95% Rat Human +DTXSID0048507 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048507 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048507 Vd NA 0.9607 L/kg 1compartment NA NA Human Human DTXSID0048507 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048507 TK.Half.Life NA 0.7309 hours 1compartment NA NA Human Human -DTXSID0048507 Css NA 0.05994 mg/L 3compartmentss NA 50% Human Human -DTXSID0048507 Css NA 0.5128 mg/L 3compartmentss NA 95% Human Human -DTXSID0048507 Css NA 0.03825 mg/L PBTK NA 50% Human Human -DTXSID0048507 Css NA 0.3109 mg/L PBTK NA 95% Human Human -DTXSID0048507 Clint NA 112.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048507 Fup NA 0.096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048507 Vd NA 0.591 L/kg 1compartment NA NA Rat Human +DTXSID0048507 TK.Half.Life NA 1.799 hours 1compartment NA NA Human Human +DTXSID0048507 Css NA 0.1401 mg/L 3compartmentss NA 50% Human Human +DTXSID0048507 Css NA 0.9985 mg/L 3compartmentss NA 95% Human Human +DTXSID0048507 Css NA 0.1117 mg/L PBTK NA 50% Human Human +DTXSID0048507 Css NA 0.6876 mg/L PBTK NA 95% Human Human +DTXSID0048507 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048507 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048507 Vd NA 0.8721 L/kg 1compartment NA NA Rat Human DTXSID0048507 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048507 TK.Half.Life NA 0.3677 hours 1compartment NA NA Rat Human -DTXSID0048507 Css NA 0.0345 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048507 Css NA 0.2363 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048507 Css NA 0.0207 mg/L PBTK NA 50% Rat Human -DTXSID0048507 Css NA 0.1368 mg/L PBTK NA 95% Rat Human -DTXSID0048509 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048509 Fup NA 0.118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048509 Vd NA 2.565 L/kg 1compartment NA NA Human Human +DTXSID0048507 TK.Half.Life NA 0.8855 hours 1compartment NA NA Rat Human +DTXSID0048507 Css NA 0.0162 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048507 Css NA 0.09399 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048507 Css NA 0.01286 mg/L PBTK NA 50% Rat Human +DTXSID0048507 Css NA 0.0615 mg/L PBTK NA 95% Rat Human +DTXSID0048509 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048509 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048509 Vd NA 2.597 L/kg 1compartment NA NA Human Human DTXSID0048509 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048509 TK.Half.Life NA 3.139 hours 1compartment NA NA Human Human -DTXSID0048509 Css NA 0.07672 mg/L 3compartmentss NA 50% Human Human -DTXSID0048509 Css NA 0.7574 mg/L 3compartmentss NA 95% Human Human -DTXSID0048509 Css NA 0.0766 mg/L PBTK NA 50% Human Human -DTXSID0048509 Css NA 0.6044 mg/L PBTK NA 95% Human Human -DTXSID0048509 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048509 Fup NA 0.118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048509 Vd NA 2.523 L/kg 1compartment NA NA Rat Human +DTXSID0048509 TK.Half.Life NA 6.123 hours 1compartment NA NA Human Human +DTXSID0048509 Css NA 0.1893 mg/L 3compartmentss NA 50% Human Human +DTXSID0048509 Css NA 1.769 mg/L 3compartmentss NA 95% Human Human +DTXSID0048509 Css NA 0.1878 mg/L PBTK NA 50% Human Human +DTXSID0048509 Css NA 1.397 mg/L PBTK NA 95% Human Human +DTXSID0048509 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048509 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048509 Vd NA 2.554 L/kg 1compartment NA NA Rat Human DTXSID0048509 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048509 TK.Half.Life NA 1.775 hours 1compartment NA NA Rat Human -DTXSID0048509 Css NA 0.04178 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048509 Css NA 0.3351 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048509 Css NA 0.04044 mg/L PBTK NA 50% Rat Human -DTXSID0048509 Css NA 0.2486 mg/L PBTK NA 95% Rat Human -DTXSID0048630 Clint NA 37.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048630 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048630 Vd NA 1.721 L/kg 1compartment NA NA Human Human -DTXSID0048630 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048630 TK.Half.Life NA 1.437 hours 1compartment NA NA Human Human -DTXSID0048630 Css NA 0.02638 mg/L 3compartmentss NA 50% Human Human -DTXSID0048630 Css NA 0.2211 mg/L 3compartmentss NA 95% Human Human -DTXSID0048630 Css NA 0.02485 mg/L PBTK NA 50% Human Human -DTXSID0048630 Css NA 0.1764 mg/L PBTK NA 95% Human Human -DTXSID0048630 Clint NA 37.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048630 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048630 Vd NA 1.685 L/kg 1compartment NA NA Rat Human -DTXSID0048630 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048630 TK.Half.Life NA 0.7223 hours 1compartment NA NA Rat Human -DTXSID0048630 Css NA 0.01424 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048630 Css NA 0.09579 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048630 Css NA 0.01311 mg/L PBTK NA 50% Rat Human -DTXSID0048630 Css NA 0.07338 mg/L PBTK NA 95% Rat Human -DTXSID0048632 Clint NA 41.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048632 Fup NA 0.1944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048632 Vd NA 2.058 L/kg 1compartment NA NA Human Human +DTXSID0048509 TK.Half.Life NA 3.681 hours 1compartment NA NA Rat Human +DTXSID0048509 Css NA 0.02302 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048509 Css NA 0.179 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048509 Css NA 0.02364 mg/L PBTK NA 50% Rat Human +DTXSID0048509 Css NA 0.1366 mg/L PBTK NA 95% Rat Human +DTXSID0048632 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048632 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048632 Vd NA 2.4 L/kg 1compartment NA NA Human Human DTXSID0048632 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048632 TK.Half.Life NA 2.135 hours 1compartment NA NA Human Human -DTXSID0048632 Css NA 0.04304 mg/L 3compartmentss NA 50% Human Human -DTXSID0048632 Css NA 0.348 mg/L 3compartmentss NA 95% Human Human -DTXSID0048632 Css NA 0.03821 mg/L PBTK NA 50% Human Human -DTXSID0048632 Css NA 0.2666 mg/L PBTK NA 95% Human Human -DTXSID0048632 Clint NA 41.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048632 Fup NA 0.1944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048632 Vd NA 2.066 L/kg 1compartment NA NA Rat Human +DTXSID0048632 TK.Half.Life NA 6.442 hours 1compartment NA NA Human Human +DTXSID0048632 Css NA 0.1914 mg/L 3compartmentss NA 50% Human Human +DTXSID0048632 Css NA 1.307 mg/L 3compartmentss NA 95% Human Human +DTXSID0048632 Css NA 0.1839 mg/L PBTK NA 50% Human Human +DTXSID0048632 Css NA 1.04 mg/L PBTK NA 95% Human Human +DTXSID0048632 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048632 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048632 Vd NA 2.418 L/kg 1compartment NA NA Rat Human DTXSID0048632 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048632 TK.Half.Life NA 1.151 hours 1compartment NA NA Rat Human -DTXSID0048632 Css NA 0.02325 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048632 Css NA 0.1436 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048632 Css NA 0.02038 mg/L PBTK NA 50% Rat Human -DTXSID0048632 Css NA 0.1094 mg/L PBTK NA 95% Rat Human -DTXSID0048634 Clint NA 170.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048634 Fup NA 0.0261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048634 Vd NA 2.383 L/kg 1compartment NA NA Human Human +DTXSID0048632 TK.Half.Life NA 3.862 hours 1compartment NA NA Rat Human +DTXSID0048632 Css NA 0.02249 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048632 Css NA 0.1194 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048632 Css NA 0.02204 mg/L PBTK NA 50% Rat Human +DTXSID0048632 Css NA 0.09169 mg/L PBTK NA 95% Rat Human +DTXSID0048634 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048634 Fup 0.058 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048634 Vd NA 1.935 L/kg 1compartment NA NA Human Human DTXSID0048634 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048634 TK.Half.Life NA 4.84 hours 1compartment NA NA Human Human -DTXSID0048634 Css NA 0.184 mg/L 3compartmentss NA 50% Human Human -DTXSID0048634 Css NA 1.411 mg/L 3compartmentss NA 95% Human Human -DTXSID0048634 Css NA 0.1216 mg/L PBTK NA 50% Human Human -DTXSID0048634 Css NA 0.8921 mg/L PBTK NA 95% Human Human -DTXSID0048634 Clint NA 170.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048634 Fup NA 0.0261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048634 Vd NA 1.776 L/kg 1compartment NA NA Rat Human +DTXSID0048634 TK.Half.Life NA 9.275 hours 1compartment NA NA Human Human +DTXSID0048634 Css NA 0.6075 mg/L 3compartmentss NA 50% Human Human +DTXSID0048634 Css NA 4.349 mg/L 3compartmentss NA 95% Human Human +DTXSID0048634 Css NA 0.3989 mg/L PBTK NA 50% Human Human +DTXSID0048634 Css NA 2.717 mg/L PBTK NA 95% Human Human +DTXSID0048634 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048634 Fup 0.058 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048634 Vd NA 1.449 L/kg 1compartment NA NA Rat Human DTXSID0048634 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048634 TK.Half.Life NA 1.402 hours 1compartment NA NA Rat Human -DTXSID0048634 Css NA 0.1045 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048634 Css NA 0.6786 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048634 Css NA 0.06528 mg/L PBTK NA 50% Rat Human -DTXSID0048634 Css NA 0.4095 mg/L PBTK NA 95% Rat Human -DTXSID0048636 Clint NA 190.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048636 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048636 Vd NA 2239 L/kg 1compartment NA NA Human Human -DTXSID0048636 Days.Css NA 2049 Days PBTK NA NA Human Human -DTXSID0048636 TK.Half.Life NA 7623 hours 1compartment NA NA Human Human -DTXSID0048636 Css NA 0.0007458 mg/L 3compartmentss NA 50% Human Human -DTXSID0048636 Css NA 0.00439 mg/L 3compartmentss NA 95% Human Human -DTXSID0048636 Css NA 0.2829 mg/L PBTK NA 50% Human Human -DTXSID0048636 Css NA 1.535 mg/L PBTK NA 95% Human Human -DTXSID0048636 Clint NA 190.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048636 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048636 Vd NA 2075 L/kg 1compartment NA NA Rat Human -DTXSID0048636 Days.Css NA 1366 Days PBTK NA NA Rat Human -DTXSID0048636 TK.Half.Life NA 1267 hours 1compartment NA NA Rat Human -DTXSID0048636 Css NA 0.0003781 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048636 Css NA 0.001689 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048636 Css NA 0.1545 mg/L PBTK NA 50% Rat Human -DTXSID0048636 Css NA 0.678 mg/L PBTK NA 95% Rat Human -DTXSID0048638 Clint NA 5.149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048638 Fup NA 0.1708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048638 Vd NA 1.62 L/kg 1compartment NA NA Human Human +DTXSID0048634 TK.Half.Life NA 3.083 hours 1compartment NA NA Rat Human +DTXSID0048634 Css NA 0.07862 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048634 Css NA 0.4422 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048634 Css NA 0.05088 mg/L PBTK NA 50% Rat Human +DTXSID0048634 Css NA 0.2745 mg/L PBTK NA 95% Rat Human +DTXSID0048636 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048636 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048636 Vd NA 28.74 L/kg 1compartment NA NA Human Human +DTXSID0048636 Days.Css NA 204 Days PBTK NA NA Human Human +DTXSID0048636 TK.Half.Life NA 850.6 hours 1compartment NA NA Human Human +DTXSID0048636 Css NA 0.7828 mg/L 3compartmentss NA 50% Human Human +DTXSID0048636 Css NA 4.897 mg/L 3compartmentss NA 95% Human Human +DTXSID0048636 Css NA 2.362 mg/L PBTK NA 50% Human Human +DTXSID0048636 Css NA 14.04 mg/L PBTK NA 95% Human Human +DTXSID0048636 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048636 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048636 Vd NA 23.7 L/kg 1compartment NA NA Rat Human +DTXSID0048636 Days.Css NA 125 Days PBTK NA NA Rat Human +DTXSID0048636 TK.Half.Life NA 121.9 hours 1compartment NA NA Rat Human +DTXSID0048636 Css NA 0.09402 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048636 Css NA 0.4297 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048636 Css NA 0.3096 mg/L PBTK NA 50% Rat Human +DTXSID0048636 Css NA 1.486 mg/L PBTK NA 95% Rat Human +DTXSID0048638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048638 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048638 Vd NA 1.003 L/kg 1compartment NA NA Human Human DTXSID0048638 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048638 TK.Half.Life NA 9.144 hours 1compartment NA NA Human Human -DTXSID0048638 Css NA 0.6414 mg/L 3compartmentss NA 50% Human Human -DTXSID0048638 Css NA 3.475 mg/L 3compartmentss NA 95% Human Human -DTXSID0048638 Css NA 0.4528 mg/L PBTK NA 50% Human Human -DTXSID0048638 Css NA 2.329 mg/L PBTK NA 95% Human Human -DTXSID0048638 Clint NA 5.149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048638 Fup NA 0.1708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048638 Vd NA 1.26 L/kg 1compartment NA NA Rat Human +DTXSID0048638 TK.Half.Life NA 2.141 hours 1compartment NA NA Human Human +DTXSID0048638 Css NA 0.1932 mg/L 3compartmentss NA 50% Human Human +DTXSID0048638 Css NA 1.622 mg/L 3compartmentss NA 95% Human Human +DTXSID0048638 Css NA 0.1289 mg/L PBTK NA 50% Human Human +DTXSID0048638 Css NA 1.016 mg/L PBTK NA 95% Human Human +DTXSID0048638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048638 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048638 Vd NA 0.8048 L/kg 1compartment NA NA Rat Human DTXSID0048638 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048638 TK.Half.Life NA 3.409 hours 1compartment NA NA Rat Human -DTXSID0048638 Css NA 0.326 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048638 Css NA 1.271 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048638 Css NA 0.2184 mg/L PBTK NA 50% Rat Human -DTXSID0048638 Css NA 0.7883 mg/L PBTK NA 95% Rat Human +DTXSID0048638 TK.Half.Life NA 0.9382 hours 1compartment NA NA Rat Human +DTXSID0048638 Css NA 0.02556 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048638 Css NA 0.1535 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048638 Css NA 0.01661 mg/L PBTK NA 50% Rat Human +DTXSID0048638 Css NA 0.0938 mg/L PBTK NA 95% Rat Human DTXSID0048680 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0048680 Fup NA 0.2518 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048680 Vd NA 0.5307 L/kg 1compartment NA NA Human Human +DTXSID0048680 Vd NA 0.4193 L/kg 1compartment NA NA Human Human DTXSID0048680 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0048680 TK.Half.Life NA 13.76 hours 1compartment NA NA Human Human -DTXSID0048680 Css NA 3.058 mg/L 3compartmentss NA 50% Human Human -DTXSID0048680 Css NA 11.6 mg/L 3compartmentss NA 95% Human Human -DTXSID0048680 Css NA 2.128 mg/L PBTK NA 50% Human Human -DTXSID0048680 Css NA 7.199 mg/L PBTK NA 95% Human Human +DTXSID0048680 TK.Half.Life NA 10.77 hours 1compartment NA NA Human Human +DTXSID0048680 Css NA 1.64 mg/L 3compartmentss NA 50% Human Human +DTXSID0048680 Css NA 6.863 mg/L 3compartmentss NA 95% Human Human +DTXSID0048680 Css NA 1.122 mg/L PBTK NA 50% Human Human +DTXSID0048680 Css NA 4.249 mg/L PBTK NA 95% Human Human DTXSID0048680 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0048680 Fup NA 0.2518 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048680 Vd NA 0.5082 L/kg 1compartment NA NA Rat Human +DTXSID0048680 Vd NA 0.4278 L/kg 1compartment NA NA Rat Human DTXSID0048680 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048680 TK.Half.Life NA 4.458 hours 1compartment NA NA Rat Human -DTXSID0048680 Css NA 0.846 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048680 Css NA 2.691 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048680 Css NA 0.5546 mg/L PBTK NA 50% Rat Human -DTXSID0048680 Css NA 1.563 mg/L PBTK NA 95% Rat Human +DTXSID0048680 TK.Half.Life NA 3.747 hours 1compartment NA NA Rat Human +DTXSID0048680 Css NA 0.008895 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048680 Css NA 0.03721 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048680 Css NA 0.005767 mg/L PBTK NA 50% Rat Human +DTXSID0048680 Css NA 0.02213 mg/L PBTK NA 95% Rat Human DTXSID0048682 Clint NA 68.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0048682 Fup 0.35 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID0048682 Vd NA 1.583 L/kg 1compartment NA NA Human Human +DTXSID0048682 Vd NA 0.6217 L/kg 1compartment NA NA Human Human DTXSID0048682 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048682 TK.Half.Life NA 1.167 hours 1compartment NA NA Human Human -DTXSID0048682 Css NA 0.01532 mg/L 3compartmentss NA 50% Human Human -DTXSID0048682 Css NA 0.1276 mg/L 3compartmentss NA 95% Human Human -DTXSID0048682 Css NA 0.01389 mg/L PBTK NA 50% Human Human -DTXSID0048682 Css NA 0.09672 mg/L PBTK NA 95% Human Human +DTXSID0048682 TK.Half.Life NA 0.5554 hours 1compartment NA NA Human Human +DTXSID0048682 Css NA 0.01257 mg/L 3compartmentss NA 50% Human Human +DTXSID0048682 Css NA 0.1264 mg/L 3compartmentss NA 95% Human Human +DTXSID0048682 Css NA 0.009142 mg/L PBTK NA 50% Human Human +DTXSID0048682 Css NA 0.08485 mg/L PBTK NA 95% Human Human DTXSID0048682 Clint NA 68.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0048682 Fup 0.35 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID0048682 Vd NA 1.558 L/kg 1compartment NA NA Rat Human +DTXSID0048682 Vd NA 0.6001 L/kg 1compartment NA NA Rat Human DTXSID0048682 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048682 TK.Half.Life NA 0.5563 hours 1compartment NA NA Rat Human -DTXSID0048682 Css NA 0.008192 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048682 Css NA 0.05758 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048682 Css NA 0.007307 mg/L PBTK NA 50% Rat Human -DTXSID0048682 Css NA 0.04273 mg/L PBTK NA 95% Rat Human -DTXSID0048684 Clint NA 13.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048684 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048684 Vd NA 2.269 L/kg 1compartment NA NA Human Human -DTXSID0048684 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID0048684 TK.Half.Life NA 67.1 hours 1compartment NA NA Human Human -DTXSID0048684 Css NA 4.6 mg/L 3compartmentss NA 50% Human Human -DTXSID0048684 Css NA 36.09 mg/L 3compartmentss NA 95% Human Human -DTXSID0048684 Css NA 2.982 mg/L PBTK NA 50% Human Human -DTXSID0048684 Css NA 22.28 mg/L PBTK NA 95% Human Human -DTXSID0048684 Clint NA 13.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048684 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048684 Vd NA 1.685 L/kg 1compartment NA NA Rat Human -DTXSID0048684 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID0048684 TK.Half.Life NA 18.67 hours 1compartment NA NA Rat Human -DTXSID0048684 Css NA 2.574 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048684 Css NA 15.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048684 Css NA 1.575 mg/L PBTK NA 50% Rat Human -DTXSID0048684 Css NA 9.256 mg/L PBTK NA 95% Rat Human -DTXSID0048686 Clint NA 32.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048686 Fup NA 0.2011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048686 Vd NA 1.303 L/kg 1compartment NA NA Human Human -DTXSID0048686 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048686 TK.Half.Life NA 1.836 hours 1compartment NA NA Human Human -DTXSID0048686 Css NA 0.08096 mg/L 3compartmentss NA 50% Human Human -DTXSID0048686 Css NA 0.5346 mg/L 3compartmentss NA 95% Human Human -DTXSID0048686 Css NA 0.0578 mg/L PBTK NA 50% Human Human -DTXSID0048686 Css NA 0.356 mg/L PBTK NA 95% Human Human -DTXSID0048686 Clint NA 32.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048686 Fup NA 0.2011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048686 Vd NA 1.042 L/kg 1compartment NA NA Rat Human -DTXSID0048686 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048686 TK.Half.Life NA 0.7348 hours 1compartment NA NA Rat Human -DTXSID0048686 Css NA 0.04464 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048686 Css NA 0.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048686 Css NA 0.03053 mg/L PBTK NA 50% Rat Human -DTXSID0048686 Css NA 0.1539 mg/L PBTK NA 95% Rat Human -DTXSID0048688 Clint NA 45.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048688 Fup NA 0.0026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048688 Vd NA 0.221 L/kg 1compartment NA NA Human Human +DTXSID0048682 TK.Half.Life NA 0.2539 hours 1compartment NA NA Rat Human +DTXSID0048682 Css NA 0.0004431 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048682 Css NA 0.005021 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048682 Css NA 0.0003184 mg/L PBTK NA 50% Rat Human +DTXSID0048682 Css NA 0.003285 mg/L PBTK NA 95% Rat Human +DTXSID0048684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048684 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048684 Vd NA 2.419 L/kg 1compartment NA NA Human Human +DTXSID0048684 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0048684 TK.Half.Life NA 33.02 hours 1compartment NA NA Human Human +DTXSID0048684 Css NA 1.928 mg/L 3compartmentss NA 50% Human Human +DTXSID0048684 Css NA 14.72 mg/L 3compartmentss NA 95% Human Human +DTXSID0048684 Css NA 1.267 mg/L PBTK NA 50% Human Human +DTXSID0048684 Css NA 9.242 mg/L PBTK NA 95% Human Human +DTXSID0048684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048684 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048684 Vd NA 1.802 L/kg 1compartment NA NA Rat Human +DTXSID0048684 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0048684 TK.Half.Life NA 8.549 hours 1compartment NA NA Rat Human +DTXSID0048684 Css NA 0.2526 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048684 Css NA 1.573 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048684 Css NA 0.1624 mg/L PBTK NA 50% Rat Human +DTXSID0048684 Css NA 0.9839 mg/L PBTK NA 95% Rat Human +DTXSID0048686 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048686 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048686 Vd NA 1.504 L/kg 1compartment NA NA Human Human +DTXSID0048686 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID0048686 TK.Half.Life NA 47.12 hours 1compartment NA NA Human Human +DTXSID0048686 Css NA 3.31 mg/L 3compartmentss NA 50% Human Human +DTXSID0048686 Css NA 12.04 mg/L 3compartmentss NA 95% Human Human +DTXSID0048686 Css NA 2.496 mg/L PBTK NA 50% Human Human +DTXSID0048686 Css NA 7.935 mg/L PBTK NA 95% Human Human +DTXSID0048686 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048686 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048686 Vd NA 1.207 L/kg 1compartment NA NA Rat Human +DTXSID0048686 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0048686 TK.Half.Life NA 10.6 hours 1compartment NA NA Rat Human +DTXSID0048686 Css NA 0.2122 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048686 Css NA 0.6592 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048686 Css NA 0.1577 mg/L PBTK NA 50% Rat Human +DTXSID0048686 Css NA 0.4148 mg/L PBTK NA 95% Rat Human +DTXSID0048688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048688 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048688 Vd NA 0.4026 L/kg 1compartment NA NA Human Human DTXSID0048688 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048688 TK.Half.Life NA 6.966 hours 1compartment NA NA Human Human -DTXSID0048688 Css NA 6.236 mg/L 3compartmentss NA 50% Human Human -DTXSID0048688 Css NA 52.44 mg/L 3compartmentss NA 95% Human Human -DTXSID0048688 Css NA 3.622 mg/L PBTK NA 50% Human Human -DTXSID0048688 Css NA 30.16 mg/L PBTK NA 95% Human Human -DTXSID0048688 Clint NA 45.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048688 Fup NA 0.0026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048688 Vd NA 0.2031 L/kg 1compartment NA NA Rat Human +DTXSID0048688 TK.Half.Life NA 5.169 hours 1compartment NA NA Human Human +DTXSID0048688 Css NA 2.154 mg/L 3compartmentss NA 50% Human Human +DTXSID0048688 Css NA 22.7 mg/L 3compartmentss NA 95% Human Human +DTXSID0048688 Css NA 1.322 mg/L PBTK NA 50% Human Human +DTXSID0048688 Css NA 13.22 mg/L PBTK NA 95% Human Human +DTXSID0048688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048688 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048688 Vd NA 0.355 L/kg 1compartment NA NA Rat Human DTXSID0048688 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048688 TK.Half.Life NA 4.381 hours 1compartment NA NA Rat Human -DTXSID0048688 Css NA 3.624 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048688 Css NA 23.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048688 Css NA 1.978 mg/L PBTK NA 50% Rat Human -DTXSID0048688 Css NA 12.65 mg/L PBTK NA 95% Rat Human -DTXSID0048711 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048711 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048711 Vd NA 0.5966 L/kg 1compartment NA NA Human Human +DTXSID0048688 TK.Half.Life NA 3.005 hours 1compartment NA NA Rat Human +DTXSID0048688 Css NA 0.2831 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048688 Css NA 2.269 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048688 Css NA 0.1672 mg/L PBTK NA 50% Rat Human +DTXSID0048688 Css NA 1.288 mg/L PBTK NA 95% Rat Human +DTXSID0048711 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048711 Fup 0.846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048711 Vd NA 0.5461 L/kg 1compartment NA NA Human Human DTXSID0048711 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048711 TK.Half.Life NA 3.862 hours 1compartment NA NA Human Human -DTXSID0048711 Css NA 0.8894 mg/L 3compartmentss NA 50% Human Human -DTXSID0048711 Css NA 5.625 mg/L 3compartmentss NA 95% Human Human -DTXSID0048711 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID0048711 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID0048711 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048711 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048711 Vd NA 0.6375 L/kg 1compartment NA NA Rat Human +DTXSID0048711 TK.Half.Life NA 4.176 hours 1compartment NA NA Human Human +DTXSID0048711 Css NA 0.891 mg/L 3compartmentss NA 50% Human Human +DTXSID0048711 Css NA 5.097 mg/L 3compartmentss NA 95% Human Human +DTXSID0048711 Css NA 0.6809 mg/L PBTK NA 50% Human Human +DTXSID0048711 Css NA 3.248 mg/L PBTK NA 95% Human Human +DTXSID0048711 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048711 Fup 0.846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048711 Vd NA 0.582 L/kg 1compartment NA NA Rat Human DTXSID0048711 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048711 TK.Half.Life NA 1.405 hours 1compartment NA NA Rat Human -DTXSID0048711 Css NA 0.2249 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048711 Css NA 1.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048711 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0048711 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0048713 Clint NA 10.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048713 Fup NA 0.1908 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048713 Vd NA 0.3538 L/kg 1compartment NA NA Human Human -DTXSID0048713 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048713 TK.Half.Life NA 0.9161 hours 1compartment NA NA Human Human -DTXSID0048713 Css NA 0.2418 mg/L 3compartmentss NA 50% Human Human -DTXSID0048713 Css NA 1.511 mg/L 3compartmentss NA 95% Human Human -DTXSID0048713 Css NA 0.1586 mg/L PBTK NA 50% Human Human -DTXSID0048713 Css NA 0.9477 mg/L PBTK NA 95% Human Human -DTXSID0048713 Clint NA 10.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048713 Fup NA 0.1908 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048713 Vd NA 0.3475 L/kg 1compartment NA NA Rat Human +DTXSID0048711 TK.Half.Life NA 1.517 hours 1compartment NA NA Rat Human +DTXSID0048711 Css NA 0.02349 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048711 Css NA 0.1513 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048711 Css NA 0.01738 mg/L PBTK NA 50% Rat Human +DTXSID0048711 Css NA 0.09363 mg/L PBTK NA 95% Rat Human +DTXSID0048713 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048713 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048713 Vd NA 0.4186 L/kg 1compartment NA NA Human Human +DTXSID0048713 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0048713 TK.Half.Life NA 9.936 hours 1compartment NA NA Human Human +DTXSID0048713 Css NA 2.413 mg/L 3compartmentss NA 50% Human Human +DTXSID0048713 Css NA 9.568 mg/L 3compartmentss NA 95% Human Human +DTXSID0048713 Css NA 1.661 mg/L PBTK NA 50% Human Human +DTXSID0048713 Css NA 5.983 mg/L PBTK NA 95% Human Human +DTXSID0048713 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048713 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048713 Vd NA 0.4121 L/kg 1compartment NA NA Rat Human DTXSID0048713 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048713 TK.Half.Life NA 0.5247 hours 1compartment NA NA Rat Human -DTXSID0048713 Css NA 0.1291 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048713 Css NA 0.6035 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048713 Css NA 0.08008 mg/L PBTK NA 50% Rat Human -DTXSID0048713 Css NA 0.3575 mg/L PBTK NA 95% Rat Human -DTXSID0048715 Clint NA 16.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048715 Fup NA 0.1592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048715 Vd NA 1.281 L/kg 1compartment NA NA Human Human +DTXSID0048713 TK.Half.Life NA 3.329 hours 1compartment NA NA Rat Human +DTXSID0048713 Css NA 0.05769 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048713 Css NA 0.322 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048713 Css NA 0.03928 mg/L PBTK NA 50% Rat Human +DTXSID0048713 Css NA 0.1985 mg/L PBTK NA 95% Rat Human +DTXSID0048715 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048715 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048715 Vd NA 1.118 L/kg 1compartment NA NA Human Human DTXSID0048715 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048715 TK.Half.Life NA 2.993 hours 1compartment NA NA Human Human -DTXSID0048715 Css NA 0.2204 mg/L 3compartmentss NA 50% Human Human -DTXSID0048715 Css NA 1.568 mg/L 3compartmentss NA 95% Human Human -DTXSID0048715 Css NA 0.1513 mg/L PBTK NA 50% Human Human -DTXSID0048715 Css NA 1.011 mg/L PBTK NA 95% Human Human -DTXSID0048715 Clint NA 16.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048715 Fup NA 0.1592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048715 Vd NA 1.018 L/kg 1compartment NA NA Rat Human +DTXSID0048715 TK.Half.Life NA 4.718 hours 1compartment NA NA Human Human +DTXSID0048715 Css NA 0.4312 mg/L 3compartmentss NA 50% Human Human +DTXSID0048715 Css NA 2.535 mg/L 3compartmentss NA 95% Human Human +DTXSID0048715 Css NA 0.2996 mg/L PBTK NA 50% Human Human +DTXSID0048715 Css NA 1.641 mg/L PBTK NA 95% Human Human +DTXSID0048715 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048715 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048715 Vd NA 0.9003 L/kg 1compartment NA NA Rat Human DTXSID0048715 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048715 TK.Half.Life NA 1.255 hours 1compartment NA NA Rat Human -DTXSID0048715 Css NA 0.1205 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048715 Css NA 0.6509 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048715 Css NA 0.07853 mg/L PBTK NA 50% Rat Human -DTXSID0048715 Css NA 0.3869 mg/L PBTK NA 95% Rat Human +DTXSID0048715 TK.Half.Life NA 2.073 hours 1compartment NA NA Rat Human +DTXSID0048715 Css NA 0.05164 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048715 Css NA 0.2141 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048715 Css NA 0.03535 mg/L PBTK NA 50% Rat Human +DTXSID0048715 Css NA 0.1359 mg/L PBTK NA 95% Rat Human DTXSID0048717 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0048717 Fup NA 0.8652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048717 Vd NA 0.4828 L/kg 1compartment NA NA Human Human +DTXSID0048717 Vd NA 0.483 L/kg 1compartment NA NA Human Human DTXSID0048717 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048717 TK.Half.Life NA 3.61 hours 1compartment NA NA Human Human -DTXSID0048717 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human -DTXSID0048717 Css NA 5.772 mg/L 3compartmentss NA 95% Human Human -DTXSID0048717 Css NA 0.7847 mg/L PBTK NA 50% Human Human -DTXSID0048717 Css NA 3.625 mg/L PBTK NA 95% Human Human +DTXSID0048717 TK.Half.Life NA 3.612 hours 1compartment NA NA Human Human +DTXSID0048717 Css NA 0.5798 mg/L 3compartmentss NA 50% Human Human +DTXSID0048717 Css NA 3.204 mg/L 3compartmentss NA 95% Human Human +DTXSID0048717 Css NA 0.4328 mg/L PBTK NA 50% Human Human +DTXSID0048717 Css NA 2.004 mg/L PBTK NA 95% Human Human DTXSID0048717 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0048717 Fup NA 0.8652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048717 Vd NA 0.5167 L/kg 1compartment NA NA Rat Human +DTXSID0048717 Vd NA 0.5169 L/kg 1compartment NA NA Rat Human DTXSID0048717 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID0048717 TK.Half.Life NA 1.317 hours 1compartment NA NA Rat Human -DTXSID0048717 Css NA 0.2722 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048717 Css NA 1.435 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048717 Css NA 0.1943 mg/L PBTK NA 50% Rat Human -DTXSID0048717 Css NA 0.8331 mg/L PBTK NA 95% Rat Human -DTXSID0048719 Clint NA 6.141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048719 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048719 Vd NA 1.067 L/kg 1compartment NA NA Human Human -DTXSID0048719 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048719 TK.Half.Life NA 4.767 hours 1compartment NA NA Human Human -DTXSID0048719 Css NA 0.5111 mg/L 3compartmentss NA 50% Human Human -DTXSID0048719 Css NA 3.079 mg/L 3compartmentss NA 95% Human Human -DTXSID0048719 Css NA 0.3478 mg/L PBTK NA 50% Human Human -DTXSID0048719 Css NA 1.946 mg/L PBTK NA 95% Human Human -DTXSID0048719 Clint NA 6.141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048719 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048719 Vd NA 0.8456 L/kg 1compartment NA NA Rat Human -DTXSID0048719 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048719 TK.Half.Life NA 2.061 hours 1compartment NA NA Rat Human -DTXSID0048719 Css NA 0.2642 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048719 Css NA 1.134 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048719 Css NA 0.1705 mg/L PBTK NA 50% Rat Human -DTXSID0048719 Css NA 0.6784 mg/L PBTK NA 95% Rat Human -DTXSID0048761 Clint NA 42.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048761 Fup NA 0.7113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048761 Vd NA 1.364 L/kg 1compartment NA NA Human Human +DTXSID0048717 Css NA 0.002965 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048717 Css NA 0.01791 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048717 Css NA 0.00213 mg/L PBTK NA 50% Rat Human +DTXSID0048717 Css NA 0.01087 mg/L PBTK NA 95% Rat Human +DTXSID0048719 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048719 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048719 Vd NA 1.27 L/kg 1compartment NA NA Human Human +DTXSID0048719 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0048719 TK.Half.Life NA 42.58 hours 1compartment NA NA Human Human +DTXSID0048719 Css NA 3.727 mg/L 3compartmentss NA 50% Human Human +DTXSID0048719 Css NA 12.81 mg/L 3compartmentss NA 95% Human Human +DTXSID0048719 Css NA 2.676 mg/L PBTK NA 50% Human Human +DTXSID0048719 Css NA 8.285 mg/L PBTK NA 95% Human Human +DTXSID0048719 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048719 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048719 Vd NA 1.011 L/kg 1compartment NA NA Rat Human +DTXSID0048719 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0048719 TK.Half.Life NA 9.948 hours 1compartment NA NA Rat Human +DTXSID0048719 Css NA 0.2377 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048719 Css NA 0.7078 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048719 Css NA 0.1684 mg/L PBTK NA 50% Rat Human +DTXSID0048719 Css NA 0.4367 mg/L PBTK NA 95% Rat Human +DTXSID0048761 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048761 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048761 Vd NA 0.4574 L/kg 1compartment NA NA Human Human DTXSID0048761 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048761 TK.Half.Life NA 0.897 hours 1compartment NA NA Human Human -DTXSID0048761 Css NA 0.01447 mg/L 3compartmentss NA 50% Human Human -DTXSID0048761 Css NA 0.1614 mg/L 3compartmentss NA 95% Human Human -DTXSID0048761 Css NA 0.01297 mg/L PBTK NA 50% Human Human -DTXSID0048761 Css NA 0.1211 mg/L PBTK NA 95% Human Human -DTXSID0048761 Clint NA 42.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048761 Fup NA 0.7113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048761 Vd NA 1.347 L/kg 1compartment NA NA Rat Human +DTXSID0048761 TK.Half.Life NA 5.115 hours 1compartment NA NA Human Human +DTXSID0048761 Css NA 0.7608 mg/L 3compartmentss NA 50% Human Human +DTXSID0048761 Css NA 4.974 mg/L 3compartmentss NA 95% Human Human +DTXSID0048761 Css NA 0.5526 mg/L PBTK NA 50% Human Human +DTXSID0048761 Css NA 3.033 mg/L PBTK NA 95% Human Human +DTXSID0048761 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048761 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048761 Vd NA 0.4686 L/kg 1compartment NA NA Rat Human DTXSID0048761 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048761 TK.Half.Life NA 0.4176 hours 1compartment NA NA Rat Human -DTXSID0048761 Css NA 0.007355 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048761 Css NA 0.07344 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048761 Css NA 0.006582 mg/L PBTK NA 50% Rat Human -DTXSID0048761 Css NA 0.05233 mg/L PBTK NA 95% Rat Human +DTXSID0048761 TK.Half.Life NA 1.785 hours 1compartment NA NA Rat Human +DTXSID0048761 Css NA 0.00396 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048761 Css NA 0.02826 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048761 Css NA 0.002782 mg/L PBTK NA 50% Rat Human +DTXSID0048761 Css NA 0.01667 mg/L PBTK NA 95% Rat Human DTXSID0048763 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0048763 Fup NA 0.0332 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048763 Vd NA 1.112 L/kg 1compartment NA NA Human Human -DTXSID0048763 Days.Css NA 60 Days PBTK NA NA Human Human -DTXSID0048763 TK.Half.Life NA 255.8 hours 1compartment NA NA Human Human -DTXSID0048763 Css NA 35.16 mg/L 3compartmentss NA 50% Human Human -DTXSID0048763 Css NA 181.3 mg/L 3compartmentss NA 95% Human Human -DTXSID0048763 Css NA 23.46 mg/L PBTK NA 50% Human Human -DTXSID0048763 Css NA 108.9 mg/L PBTK NA 95% Human Human +DTXSID0048763 Vd NA 0.175 L/kg 1compartment NA NA Human Human +DTXSID0048763 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID0048763 TK.Half.Life NA 34.09 hours 1compartment NA NA Human Human +DTXSID0048763 Css NA 29.03 mg/L 3compartmentss NA 50% Human Human +DTXSID0048763 Css NA 154.5 mg/L 3compartmentss NA 95% Human Human +DTXSID0048763 Css NA 16.93 mg/L PBTK NA 50% Human Human +DTXSID0048763 Css NA 89.28 mg/L PBTK NA 95% Human Human DTXSID0048763 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0048763 Fup NA 0.0332 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048763 Vd NA 0.8782 L/kg 1compartment NA NA Rat Human -DTXSID0048763 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID0048763 TK.Half.Life NA 60.8 hours 1compartment NA NA Rat Human -DTXSID0048763 Css NA 9.734 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048763 Css NA 44.72 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048763 Css NA 6.122 mg/L PBTK NA 50% Rat Human -DTXSID0048763 Css NA 25.12 mg/L PBTK NA 95% Rat Human -DTXSID0048765 Clint NA 6.077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048765 Fup NA 0.1471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048765 Vd NA 1.176 L/kg 1compartment NA NA Human Human +DTXSID0048763 Vd NA 0.176 L/kg 1compartment NA NA Rat Human +DTXSID0048763 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0048763 TK.Half.Life NA 11.68 hours 1compartment NA NA Rat Human +DTXSID0048763 Css NA 0.5458 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048763 Css NA 3.984 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048763 Css NA 0.3016 mg/L PBTK NA 50% Rat Human +DTXSID0048763 Css NA 2.228 mg/L PBTK NA 95% Rat Human +DTXSID0048765 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048765 Fup 0.186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048765 Vd NA 1.432 L/kg 1compartment NA NA Human Human DTXSID0048765 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048765 TK.Half.Life NA 5.914 hours 1compartment NA NA Human Human -DTXSID0048765 Css NA 0.6348 mg/L 3compartmentss NA 50% Human Human -DTXSID0048765 Css NA 4.124 mg/L 3compartmentss NA 95% Human Human -DTXSID0048765 Css NA 0.4282 mg/L PBTK NA 50% Human Human -DTXSID0048765 Css NA 2.598 mg/L PBTK NA 95% Human Human -DTXSID0048765 Clint NA 6.077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048765 Fup NA 0.1471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048765 Vd NA 0.9287 L/kg 1compartment NA NA Rat Human +DTXSID0048765 TK.Half.Life NA 2.653 hours 1compartment NA NA Human Human +DTXSID0048765 Css NA 0.1321 mg/L 3compartmentss NA 50% Human Human +DTXSID0048765 Css NA 0.8926 mg/L 3compartmentss NA 95% Human Human +DTXSID0048765 Css NA 0.09358 mg/L PBTK NA 50% Human Human +DTXSID0048765 Css NA 0.5947 mg/L PBTK NA 95% Human Human +DTXSID0048765 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048765 Fup 0.186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048765 Vd NA 1.126 L/kg 1compartment NA NA Rat Human DTXSID0048765 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048765 TK.Half.Life NA 2.516 hours 1compartment NA NA Rat Human -DTXSID0048765 Css NA 0.3292 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048765 Css NA 1.637 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048765 Css NA 0.2106 mg/L PBTK NA 50% Rat Human -DTXSID0048765 Css NA 0.9536 mg/L PBTK NA 95% Rat Human -DTXSID0048767 Clint NA 24.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048767 Fup NA 0.1127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048767 Vd NA 3.287 L/kg 1compartment NA NA Human Human -DTXSID0048767 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048767 TK.Half.Life NA 5.332 hours 1compartment NA NA Human Human -DTXSID0048767 Css NA 0.1177 mg/L 3compartmentss NA 50% Human Human -DTXSID0048767 Css NA 0.9807 mg/L 3compartmentss NA 95% Human Human -DTXSID0048767 Css NA 0.1063 mg/L PBTK NA 50% Human Human -DTXSID0048767 Css NA 0.7579 mg/L PBTK NA 95% Human Human -DTXSID0048767 Clint NA 24.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048767 Fup NA 0.1127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048767 Vd NA 3.033 L/kg 1compartment NA NA Rat Human -DTXSID0048767 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048767 TK.Half.Life NA 2.377 hours 1compartment NA NA Rat Human -DTXSID0048767 Css NA 0.06518 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048767 Css NA 0.4437 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048767 Css NA 0.057 mg/L PBTK NA 50% Rat Human -DTXSID0048767 Css NA 0.3208 mg/L PBTK NA 95% Rat Human -DTXSID0048769 Clint NA 83.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048769 Fup NA 0.1081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048769 Vd NA 3.295 L/kg 1compartment NA NA Human Human -DTXSID0048769 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048769 TK.Half.Life NA 3.703 hours 1compartment NA NA Human Human -DTXSID0048769 Css NA 0.05554 mg/L 3compartmentss NA 50% Human Human -DTXSID0048769 Css NA 0.4296 mg/L 3compartmentss NA 95% Human Human -DTXSID0048769 Css NA 0.04523 mg/L PBTK NA 50% Human Human -DTXSID0048769 Css NA 0.3224 mg/L PBTK NA 95% Human Human -DTXSID0048769 Clint NA 83.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048769 Fup NA 0.1081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048769 Vd NA 2.813 L/kg 1compartment NA NA Rat Human -DTXSID0048769 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048769 TK.Half.Life NA 1.295 hours 1compartment NA NA Rat Human -DTXSID0048769 Css NA 0.03108 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048769 Css NA 0.1873 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048769 Css NA 0.02454 mg/L PBTK NA 50% Rat Human -DTXSID0048769 Css NA 0.1345 mg/L PBTK NA 95% Rat Human -DTXSID0048840 Clint NA 182.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048840 Fup NA 0.4937 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048840 Vd NA 3.331 L/kg 1compartment NA NA Human Human +DTXSID0048765 TK.Half.Life NA 1.048 hours 1compartment NA NA Rat Human +DTXSID0048765 Css NA 0.01662 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048765 Css NA 0.0881 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048765 Css NA 0.01163 mg/L PBTK NA 50% Rat Human +DTXSID0048765 Css NA 0.05829 mg/L PBTK NA 95% Rat Human +DTXSID0048769 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048769 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048769 Vd NA 3.703 L/kg 1compartment NA NA Human Human +DTXSID0048769 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0048769 TK.Half.Life NA 21.15 hours 1compartment NA NA Human Human +DTXSID0048769 Css NA 0.5004 mg/L 3compartmentss NA 50% Human Human +DTXSID0048769 Css NA 3.077 mg/L 3compartmentss NA 95% Human Human +DTXSID0048769 Css NA 0.44 mg/L PBTK NA 50% Human Human +DTXSID0048769 Css NA 2.501 mg/L PBTK NA 95% Human Human +DTXSID0048769 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048769 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048769 Vd NA 3.168 L/kg 1compartment NA NA Rat Human +DTXSID0048769 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0048769 TK.Half.Life NA 5.608 hours 1compartment NA NA Rat Human +DTXSID0048769 Css NA 0.06069 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048769 Css NA 0.2805 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048769 Css NA 0.0544 mg/L PBTK NA 50% Rat Human +DTXSID0048769 Css NA 0.2305 mg/L PBTK NA 95% Rat Human +DTXSID0048840 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048840 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048840 Vd NA 3.078 L/kg 1compartment NA NA Human Human DTXSID0048840 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048840 TK.Half.Life NA 1.628 hours 1compartment NA NA Human Human -DTXSID0048840 Css NA 0.003464 mg/L 3compartmentss NA 50% Human Human -DTXSID0048840 Css NA 0.03712 mg/L 3compartmentss NA 95% Human Human -DTXSID0048840 Css NA 0.00402 mg/L PBTK NA 50% Human Human -DTXSID0048840 Css NA 0.03291 mg/L PBTK NA 95% Human Human -DTXSID0048840 Clint NA 182.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048840 Fup NA 0.4937 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048840 Vd NA 3.336 L/kg 1compartment NA NA Rat Human +DTXSID0048840 TK.Half.Life NA 4.94 hours 1compartment NA NA Human Human +DTXSID0048840 Css NA 0.09497 mg/L 3compartmentss NA 50% Human Human +DTXSID0048840 Css NA 0.7782 mg/L 3compartmentss NA 95% Human Human +DTXSID0048840 Css NA 0.106 mg/L PBTK NA 50% Human Human +DTXSID0048840 Css NA 0.6598 mg/L PBTK NA 95% Human Human +DTXSID0048840 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048840 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048840 Vd NA 3.088 L/kg 1compartment NA NA Rat Human DTXSID0048840 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048840 TK.Half.Life NA 0.7362 hours 1compartment NA NA Rat Human -DTXSID0048840 Css NA 0.001803 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048840 Css NA 0.01758 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048840 Css NA 0.002104 mg/L PBTK NA 50% Rat Human -DTXSID0048840 Css NA 0.0149 mg/L PBTK NA 95% Rat Human -DTXSID0048842 Clint NA 546.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048842 Fup NA 0.022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048842 Vd NA 3.111 L/kg 1compartment NA NA Human Human -DTXSID0048842 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048842 TK.Half.Life NA 5.64 hours 1compartment NA NA Human Human -DTXSID0048842 Css NA 0.126 mg/L 3compartmentss NA 50% Human Human -DTXSID0048842 Css NA 0.8038 mg/L 3compartmentss NA 95% Human Human -DTXSID0048842 Css NA 0.08762 mg/L PBTK NA 50% Human Human -DTXSID0048842 Css NA 0.5401 mg/L PBTK NA 95% Human Human -DTXSID0048842 Clint NA 546.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048842 Fup NA 0.022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048842 Vd NA 2.335 L/kg 1compartment NA NA Rat Human -DTXSID0048842 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048842 TK.Half.Life NA 1.252 hours 1compartment NA NA Rat Human -DTXSID0048842 Css NA 0.07068 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048842 Css NA 0.3713 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048842 Css NA 0.047 mg/L PBTK NA 50% Rat Human -DTXSID0048842 Css NA 0.236 mg/L PBTK NA 95% Rat Human -DTXSID0048844 Clint NA 7.675 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048844 Fup NA 0.1012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048844 Vd NA 0.5513 L/kg 1compartment NA NA Human Human +DTXSID0048840 TK.Half.Life NA 2.757 hours 1compartment NA NA Rat Human +DTXSID0048840 Css NA 0.01062 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048840 Css NA 0.07375 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048840 Css NA 0.01225 mg/L PBTK NA 50% Rat Human +DTXSID0048840 Css NA 0.05708 mg/L PBTK NA 95% Rat Human +DTXSID0048842 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048842 Fup 0.0777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048842 Vd NA 3.082 L/kg 1compartment NA NA Human Human +DTXSID0048842 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0048842 TK.Half.Life NA 49.58 hours 1compartment NA NA Human Human +DTXSID0048842 Css NA 1.659 mg/L 3compartmentss NA 50% Human Human +DTXSID0048842 Css NA 10.91 mg/L 3compartmentss NA 95% Human Human +DTXSID0048842 Css NA 1.152 mg/L PBTK NA 50% Human Human +DTXSID0048842 Css NA 7.439 mg/L PBTK NA 95% Human Human +DTXSID0048842 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048842 Fup 0.0777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048842 Vd NA 2.311 L/kg 1compartment NA NA Rat Human +DTXSID0048842 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID0048842 TK.Half.Life NA 7.275 hours 1compartment NA NA Rat Human +DTXSID0048842 Css NA 0.08286 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048842 Css NA 0.5459 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048842 Css NA 0.05616 mg/L PBTK NA 50% Rat Human +DTXSID0048842 Css NA 0.3537 mg/L PBTK NA 95% Rat Human +DTXSID0048844 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048844 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048844 Vd NA 1.026 L/kg 1compartment NA NA Human Human DTXSID0048844 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048844 TK.Half.Life NA 2.962 hours 1compartment NA NA Human Human -DTXSID0048844 Css NA 0.7716 mg/L 3compartmentss NA 50% Human Human -DTXSID0048844 Css NA 5.366 mg/L 3compartmentss NA 95% Human Human -DTXSID0048844 Css NA 0.4894 mg/L PBTK NA 50% Human Human -DTXSID0048844 Css NA 3.247 mg/L PBTK NA 95% Human Human -DTXSID0048844 Clint NA 7.675 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048844 Fup NA 0.1012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048844 Vd NA 0.481 L/kg 1compartment NA NA Rat Human +DTXSID0048844 TK.Half.Life NA 2.562 hours 1compartment NA NA Human Human +DTXSID0048844 Css NA 0.2109 mg/L 3compartmentss NA 50% Human Human +DTXSID0048844 Css NA 1.3 mg/L 3compartmentss NA 95% Human Human +DTXSID0048844 Css NA 0.1582 mg/L PBTK NA 50% Human Human +DTXSID0048844 Css NA 0.8724 mg/L PBTK NA 95% Human Human +DTXSID0048844 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048844 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048844 Vd NA 0.9016 L/kg 1compartment NA NA Rat Human DTXSID0048844 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048844 TK.Half.Life NA 1.562 hours 1compartment NA NA Rat Human -DTXSID0048844 Css NA 0.4062 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048844 Css NA 2.149 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048844 Css NA 0.2412 mg/L PBTK NA 50% Rat Human -DTXSID0048844 Css NA 1.212 mg/L PBTK NA 95% Rat Human -DTXSID0048846 Clint NA 52.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048846 Fup NA 0.0253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048846 Vd NA 2.818 L/kg 1compartment NA NA Human Human -DTXSID0048846 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0048846 TK.Half.Life NA 17.9 hours 1compartment NA NA Human Human -DTXSID0048846 Css NA 0.7828 mg/L 3compartmentss NA 50% Human Human -DTXSID0048846 Css NA 5.107 mg/L 3compartmentss NA 95% Human Human -DTXSID0048846 Css NA 0.5307 mg/L PBTK NA 50% Human Human -DTXSID0048846 Css NA 3.296 mg/L PBTK NA 95% Human Human -DTXSID0048846 Clint NA 52.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048846 Fup NA 0.0253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048846 Vd NA 2.109 L/kg 1compartment NA NA Rat Human -DTXSID0048846 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048846 TK.Half.Life NA 3.677 hours 1compartment NA NA Rat Human -DTXSID0048846 Css NA 0.4421 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048846 Css NA 2.501 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048846 Css NA 0.2854 mg/L PBTK NA 50% Rat Human -DTXSID0048846 Css NA 1.571 mg/L PBTK NA 95% Rat Human -DTXSID0048848 Clint NA 13.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048848 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048848 Vd NA 0.8763 L/kg 1compartment NA NA Human Human +DTXSID0048844 TK.Half.Life NA 1.238 hours 1compartment NA NA Rat Human +DTXSID0048844 Css NA 0.02456 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048844 Css NA 0.1218 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048844 Css NA 0.01844 mg/L PBTK NA 50% Rat Human +DTXSID0048844 Css NA 0.07985 mg/L PBTK NA 95% Rat Human +DTXSID0048846 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048846 Fup 0.0582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048846 Vd NA 3.109 L/kg 1compartment NA NA Human Human +DTXSID0048846 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID0048846 TK.Half.Life NA 50.74 hours 1compartment NA NA Human Human +DTXSID0048846 Css NA 1.884 mg/L 3compartmentss NA 50% Human Human +DTXSID0048846 Css NA 12.7 mg/L 3compartmentss NA 95% Human Human +DTXSID0048846 Css NA 1.318 mg/L PBTK NA 50% Human Human +DTXSID0048846 Css NA 8.61 mg/L PBTK NA 95% Human Human +DTXSID0048846 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048846 Fup 0.0582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048846 Vd NA 2.348 L/kg 1compartment NA NA Rat Human +DTXSID0048846 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID0048846 TK.Half.Life NA 7.677 hours 1compartment NA NA Rat Human +DTXSID0048846 Css NA 0.2468 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048846 Css NA 1.421 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048846 Css NA 0.1713 mg/L PBTK NA 50% Rat Human +DTXSID0048846 Css NA 0.9601 mg/L PBTK NA 95% Rat Human +DTXSID0048848 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048848 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048848 Vd NA 0.5089 L/kg 1compartment NA NA Human Human DTXSID0048848 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048848 TK.Half.Life NA 0.6829 hours 1compartment NA NA Human Human -DTXSID0048848 Css NA 0.0373 mg/L 3compartmentss NA 50% Human Human -DTXSID0048848 Css NA 0.4206 mg/L 3compartmentss NA 95% Human Human -DTXSID0048848 Css NA 0.03183 mg/L PBTK NA 50% Human Human -DTXSID0048848 Css NA 0.3208 mg/L PBTK NA 95% Human Human -DTXSID0048848 Clint NA 13.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048848 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048848 Vd NA 0.8999 L/kg 1compartment NA NA Rat Human +DTXSID0048848 TK.Half.Life NA 6.678 hours 1compartment NA NA Human Human +DTXSID0048848 Css NA 1.457 mg/L 3compartmentss NA 50% Human Human +DTXSID0048848 Css NA 7.066 mg/L 3compartmentss NA 95% Human Human +DTXSID0048848 Css NA 1.085 mg/L PBTK NA 50% Human Human +DTXSID0048848 Css NA 4.407 mg/L PBTK NA 95% Human Human +DTXSID0048848 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048848 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048848 Vd NA 0.5326 L/kg 1compartment NA NA Rat Human DTXSID0048848 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048848 TK.Half.Life NA 0.3462 hours 1compartment NA NA Rat Human -DTXSID0048848 Css NA 0.01834 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048848 Css NA 0.1605 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048848 Css NA 0.01549 mg/L PBTK NA 50% Rat Human -DTXSID0048848 Css NA 0.1138 mg/L PBTK NA 95% Rat Human -DTXSID0048890 Clint NA 729.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048890 Fup NA 0.7647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048890 Vd NA 2.523 L/kg 1compartment NA NA Human Human -DTXSID0048890 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048890 TK.Half.Life NA 1.142 hours 1compartment NA NA Human Human -DTXSID0048890 Css NA 0.0006987 mg/L 3compartmentss NA 50% Human Human -DTXSID0048890 Css NA 0.008528 mg/L 3compartmentss NA 95% Human Human -DTXSID0048890 Css NA 0.000743 mg/L PBTK NA 50% Human Human -DTXSID0048890 Css NA 0.007018 mg/L PBTK NA 95% Human Human -DTXSID0048890 Clint NA 729.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048890 Fup NA 0.7647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048890 Vd NA 2.564 L/kg 1compartment NA NA Rat Human -DTXSID0048890 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048890 TK.Half.Life NA 0.5056 hours 1compartment NA NA Rat Human -DTXSID0048890 Css NA 0.0003584 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048890 Css NA 0.004334 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048890 Css NA 0.0003848 mg/L PBTK NA 50% Rat Human -DTXSID0048890 Css NA 0.003448 mg/L PBTK NA 95% Rat Human -DTXSID0048892 Clint NA 79.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048892 Fup NA 0.5447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048892 Vd NA 2.223 L/kg 1compartment NA NA Human Human +DTXSID0048848 TK.Half.Life NA 2.382 hours 1compartment NA NA Rat Human +DTXSID0048848 Css NA 0.09124 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048848 Css NA 0.3941 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048848 Css NA 0.06706 mg/L PBTK NA 50% Rat Human +DTXSID0048848 Css NA 0.2398 mg/L PBTK NA 95% Rat Human +DTXSID0048890 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048890 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048890 Vd NA 2.73 L/kg 1compartment NA NA Human Human +DTXSID0048890 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID0048890 TK.Half.Life NA 38.49 hours 1compartment NA NA Human Human +DTXSID0048890 Css NA 1.056 mg/L 3compartmentss NA 50% Human Human +DTXSID0048890 Css NA 6.189 mg/L 3compartmentss NA 95% Human Human +DTXSID0048890 Css NA 1.146 mg/L PBTK NA 50% Human Human +DTXSID0048890 Css NA 4.589 mg/L PBTK NA 95% Human Human +DTXSID0048890 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048890 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048890 Vd NA 2.768 L/kg 1compartment NA NA Rat Human +DTXSID0048890 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID0048890 TK.Half.Life NA 13.23 hours 1compartment NA NA Rat Human +DTXSID0048890 Css NA 0.065 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048890 Css NA 0.3397 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048890 Css NA 0.07236 mg/L PBTK NA 50% Rat Human +DTXSID0048890 Css NA 0.2459 mg/L PBTK NA 95% Rat Human +DTXSID0048892 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048892 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048892 Vd NA 2.032 L/kg 1compartment NA NA Human Human DTXSID0048892 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048892 TK.Half.Life NA 1.236 hours 1compartment NA NA Human Human -DTXSID0048892 Css NA 0.007748 mg/L 3compartmentss NA 50% Human Human -DTXSID0048892 Css NA 0.08431 mg/L 3compartmentss NA 95% Human Human -DTXSID0048892 Css NA 0.008248 mg/L PBTK NA 50% Human Human -DTXSID0048892 Css NA 0.07 mg/L PBTK NA 95% Human Human -DTXSID0048892 Clint NA 79.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048892 Fup NA 0.5447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048892 Vd NA 2.199 L/kg 1compartment NA NA Rat Human +DTXSID0048892 TK.Half.Life NA 3.182 hours 1compartment NA NA Human Human +DTXSID0048892 Css NA 0.09659 mg/L 3compartmentss NA 50% Human Human +DTXSID0048892 Css NA 0.8524 mg/L 3compartmentss NA 95% Human Human +DTXSID0048892 Css NA 0.09863 mg/L PBTK NA 50% Human Human +DTXSID0048892 Css NA 0.6565 mg/L PBTK NA 95% Human Human +DTXSID0048892 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048892 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048892 Vd NA 2.007 L/kg 1compartment NA NA Rat Human DTXSID0048892 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048892 TK.Half.Life NA 0.5724 hours 1compartment NA NA Rat Human -DTXSID0048892 Css NA 0.00402 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048892 Css NA 0.0434 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048892 Css NA 0.004292 mg/L PBTK NA 50% Rat Human -DTXSID0048892 Css NA 0.03274 mg/L PBTK NA 95% Rat Human -DTXSID0048894 Clint NA 14.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048894 Fup NA 0.4364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048894 Vd NA 1.044 L/kg 1compartment NA NA Human Human -DTXSID0048894 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048894 TK.Half.Life NA 1.284 hours 1compartment NA NA Human Human -DTXSID0048894 Css NA 0.06874 mg/L 3compartmentss NA 50% Human Human -DTXSID0048894 Css NA 0.5074 mg/L 3compartmentss NA 95% Human Human -DTXSID0048894 Css NA 0.05509 mg/L PBTK NA 50% Human Human -DTXSID0048894 Css NA 0.36 mg/L PBTK NA 95% Human Human -DTXSID0048894 Clint NA 14.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048894 Fup NA 0.4364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048894 Vd NA 0.9746 L/kg 1compartment NA NA Rat Human +DTXSID0048892 TK.Half.Life NA 1.787 hours 1compartment NA NA Rat Human +DTXSID0048892 Css NA 0.01082 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048892 Css NA 0.07546 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048892 Css NA 0.01147 mg/L PBTK NA 50% Rat Human +DTXSID0048892 Css NA 0.0557 mg/L PBTK NA 95% Rat Human +DTXSID0048894 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048894 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048894 Vd NA 1.132 L/kg 1compartment NA NA Human Human +DTXSID0048894 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0048894 TK.Half.Life NA 12.7 hours 1compartment NA NA Human Human +DTXSID0048894 Css NA 1.143 mg/L 3compartmentss NA 50% Human Human +DTXSID0048894 Css NA 8.021 mg/L 3compartmentss NA 95% Human Human +DTXSID0048894 Css NA 0.9829 mg/L PBTK NA 50% Human Human +DTXSID0048894 Css NA 5.19 mg/L PBTK NA 95% Human Human +DTXSID0048894 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048894 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048894 Vd NA 1.034 L/kg 1compartment NA NA Rat Human DTXSID0048894 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048894 TK.Half.Life NA 0.6301 hours 1compartment NA NA Rat Human -DTXSID0048894 Css NA 0.0361 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048894 Css NA 0.2146 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048894 Css NA 0.02769 mg/L PBTK NA 50% Rat Human -DTXSID0048894 Css NA 0.141 mg/L PBTK NA 95% Rat Human -DTXSID0048896 Clint NA 8.407 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048896 Fup NA 0.3086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048896 Vd NA 1.274 L/kg 1compartment NA NA Human Human +DTXSID0048894 TK.Half.Life NA 3.761 hours 1compartment NA NA Rat Human +DTXSID0048894 Css NA 0.06995 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048894 Css NA 0.4559 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048894 Css NA 0.05992 mg/L PBTK NA 50% Rat Human +DTXSID0048894 Css NA 0.2831 mg/L PBTK NA 95% Rat Human +DTXSID0048896 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048896 Fup 0.547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048896 Vd NA 1.269 L/kg 1compartment NA NA Human Human DTXSID0048896 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048896 TK.Half.Life NA 2.433 hours 1compartment NA NA Human Human -DTXSID0048896 Css NA 0.1402 mg/L 3compartmentss NA 50% Human Human -DTXSID0048896 Css NA 1.004 mg/L 3compartmentss NA 95% Human Human -DTXSID0048896 Css NA 0.1163 mg/L PBTK NA 50% Human Human -DTXSID0048896 Css NA 0.7266 mg/L PBTK NA 95% Human Human -DTXSID0048896 Clint NA 8.407 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048896 Fup NA 0.3086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048896 Vd NA 1.244 L/kg 1compartment NA NA Rat Human +DTXSID0048896 TK.Half.Life NA 1.95 hours 1compartment NA NA Human Human +DTXSID0048896 Css NA 0.1092 mg/L 3compartmentss NA 50% Human Human +DTXSID0048896 Css NA 1 mg/L 3compartmentss NA 95% Human Human +DTXSID0048896 Css NA 0.09526 mg/L PBTK NA 50% Human Human +DTXSID0048896 Css NA 0.6906 mg/L PBTK NA 95% Human Human +DTXSID0048896 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048896 Fup 0.547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048896 Vd NA 1.286 L/kg 1compartment NA NA Rat Human DTXSID0048896 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048896 TK.Half.Life NA 1.368 hours 1compartment NA NA Rat Human -DTXSID0048896 Css NA 0.07212 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048896 Css NA 0.3939 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048896 Css NA 0.05842 mg/L PBTK NA 50% Rat Human -DTXSID0048896 Css NA 0.2638 mg/L PBTK NA 95% Rat Human -DTXSID0048898 Clint NA 2.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048898 Fup NA 0.1532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048898 Vd NA 0.3838 L/kg 1compartment NA NA Human Human +DTXSID0048896 TK.Half.Life NA 1.092 hours 1compartment NA NA Rat Human +DTXSID0048896 Css NA 0.01237 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048896 Css NA 0.09528 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048896 Css NA 0.01089 mg/L PBTK NA 50% Rat Human +DTXSID0048896 Css NA 0.06145 mg/L PBTK NA 95% Rat Human +DTXSID0048898 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048898 Fup 0.701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048898 Vd NA 0.7775 L/kg 1compartment NA NA Human Human DTXSID0048898 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048898 TK.Half.Life NA 3.041 hours 1compartment NA NA Human Human -DTXSID0048898 Css NA 1.099 mg/L 3compartmentss NA 50% Human Human -DTXSID0048898 Css NA 6.264 mg/L 3compartmentss NA 95% Human Human -DTXSID0048898 Css NA 0.7008 mg/L PBTK NA 50% Human Human -DTXSID0048898 Css NA 3.771 mg/L PBTK NA 95% Human Human -DTXSID0048898 Clint NA 2.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048898 Fup NA 0.1532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048898 Vd NA 0.3731 L/kg 1compartment NA NA Rat Human +DTXSID0048898 TK.Half.Life NA 7.177 hours 1compartment NA NA Human Human +DTXSID0048898 Css NA 0.5616 mg/L 3compartmentss NA 50% Human Human +DTXSID0048898 Css NA 3.759 mg/L 3compartmentss NA 95% Human Human +DTXSID0048898 Css NA 0.482 mg/L PBTK NA 50% Human Human +DTXSID0048898 Css NA 2.482 mg/L PBTK NA 95% Human Human +DTXSID0048898 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048898 Fup 0.701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048898 Vd NA 0.7909 L/kg 1compartment NA NA Rat Human DTXSID0048898 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048898 TK.Half.Life NA 1.688 hours 1compartment NA NA Rat Human -DTXSID0048898 Css NA 0.5294 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048898 Css NA 2.324 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048898 Css NA 0.3194 mg/L PBTK NA 50% Rat Human -DTXSID0048898 Css NA 1.3 mg/L PBTK NA 95% Rat Human -DTXSID0048921 Clint NA 2.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048921 Fup NA 0.3843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048921 Vd NA 4.09 L/kg 1compartment NA NA Human Human +DTXSID0048898 TK.Half.Life NA 2.487 hours 1compartment NA NA Rat Human +DTXSID0048898 Css NA 0.002916 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048898 Css NA 0.02151 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048898 Css NA 0.00243 mg/L PBTK NA 50% Rat Human +DTXSID0048898 Css NA 0.01339 mg/L PBTK NA 95% Rat Human +DTXSID0048921 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048921 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048921 Vd NA 3.479 L/kg 1compartment NA NA Human Human DTXSID0048921 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048921 TK.Half.Life NA 12.17 hours 1compartment NA NA Human Human -DTXSID0048921 Css NA 0.1818 mg/L 3compartmentss NA 50% Human Human -DTXSID0048921 Css NA 1.304 mg/L 3compartmentss NA 95% Human Human -DTXSID0048921 Css NA 0.2373 mg/L PBTK NA 50% Human Human -DTXSID0048921 Css NA 1.209 mg/L PBTK NA 95% Human Human -DTXSID0048921 Clint NA 2.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048921 Fup NA 0.3843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048921 Vd NA 4.157 L/kg 1compartment NA NA Rat Human +DTXSID0048921 TK.Half.Life NA 2.863 hours 1compartment NA NA Human Human +DTXSID0048921 Css NA 0.02824 mg/L 3compartmentss NA 50% Human Human +DTXSID0048921 Css NA 0.3009 mg/L 3compartmentss NA 95% Human Human +DTXSID0048921 Css NA 0.03369 mg/L PBTK NA 50% Human Human +DTXSID0048921 Css NA 0.2609 mg/L PBTK NA 95% Human Human +DTXSID0048921 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048921 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048921 Vd NA 3.537 L/kg 1compartment NA NA Rat Human DTXSID0048921 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048921 TK.Half.Life NA 6.904 hours 1compartment NA NA Rat Human -DTXSID0048921 Css NA 0.08216 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048921 Css NA 0.4777 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048921 Css NA 0.1083 mg/L PBTK NA 50% Rat Human -DTXSID0048921 Css NA 0.4048 mg/L PBTK NA 95% Rat Human -DTXSID0048923 Clint NA 29.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048923 Fup NA 0.0918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048923 Vd NA 3.104 L/kg 1compartment NA NA Human Human -DTXSID0048923 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0048923 TK.Half.Life NA 30.19 hours 1compartment NA NA Human Human -DTXSID0048923 Css NA 1.118 mg/L 3compartmentss NA 50% Human Human -DTXSID0048923 Css NA 7.38 mg/L 3compartmentss NA 95% Human Human -DTXSID0048923 Css NA 0.7869 mg/L PBTK NA 50% Human Human -DTXSID0048923 Css NA 5.053 mg/L PBTK NA 95% Human Human -DTXSID0048923 Clint NA 29.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048923 Fup NA 0.0918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048923 Vd NA 2.345 L/kg 1compartment NA NA Rat Human -DTXSID0048923 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0048923 TK.Half.Life NA 4.8 hours 1compartment NA NA Rat Human -DTXSID0048923 Css NA 0.6236 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048923 Css NA 3.377 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048923 Css NA 0.4208 mg/L PBTK NA 50% Rat Human -DTXSID0048923 Css NA 2.183 mg/L PBTK NA 95% Rat Human -DTXSID0048925 Clint NA 27.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048925 Fup NA 0.0441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048925 Vd NA 2.802 L/kg 1compartment NA NA Human Human +DTXSID0048921 TK.Half.Life NA 1.577 hours 1compartment NA NA Rat Human +DTXSID0048921 Css NA 0.003415 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048921 Css NA 0.02637 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048921 Css NA 0.004273 mg/L PBTK NA 50% Rat Human +DTXSID0048921 Css NA 0.02357 mg/L PBTK NA 95% Rat Human +DTXSID0048923 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048923 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048923 Vd NA 2.219 L/kg 1compartment NA NA Human Human +DTXSID0048923 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0048923 TK.Half.Life NA 2.312 hours 1compartment NA NA Human Human +DTXSID0048923 Css NA 0.0442 mg/L 3compartmentss NA 50% Human Human +DTXSID0048923 Css NA 0.392 mg/L 3compartmentss NA 95% Human Human +DTXSID0048923 Css NA 0.04413 mg/L PBTK NA 50% Human Human +DTXSID0048923 Css NA 0.3169 mg/L PBTK NA 95% Human Human +DTXSID0048923 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048923 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048923 Vd NA 2.204 L/kg 1compartment NA NA Rat Human +DTXSID0048923 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0048923 TK.Half.Life NA 1.268 hours 1compartment NA NA Rat Human +DTXSID0048923 Css NA 0.005428 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048923 Css NA 0.0361 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048923 Css NA 0.005537 mg/L PBTK NA 50% Rat Human +DTXSID0048923 Css NA 0.02995 mg/L PBTK NA 95% Rat Human +DTXSID0048925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048925 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048925 Vd NA 1.851 L/kg 1compartment NA NA Human Human DTXSID0048925 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048925 TK.Half.Life NA 4.919 hours 1compartment NA NA Human Human -DTXSID0048925 Css NA 0.146 mg/L 3compartmentss NA 50% Human Human -DTXSID0048925 Css NA 1.347 mg/L 3compartmentss NA 95% Human Human -DTXSID0048925 Css NA 0.1144 mg/L PBTK NA 50% Human Human -DTXSID0048925 Css NA 0.9369 mg/L PBTK NA 95% Human Human -DTXSID0048925 Clint NA 27.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048925 Fup NA 0.0441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048925 Vd NA 2.48 L/kg 1compartment NA NA Rat Human +DTXSID0048925 TK.Half.Life NA 3.052 hours 1compartment NA NA Human Human +DTXSID0048925 Css NA 0.1176 mg/L 3compartmentss NA 50% Human Human +DTXSID0048925 Css NA 1.045 mg/L 3compartmentss NA 95% Human Human +DTXSID0048925 Css NA 0.09567 mg/L PBTK NA 50% Human Human +DTXSID0048925 Css NA 0.7227 mg/L PBTK NA 95% Human Human +DTXSID0048925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048925 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048925 Vd NA 1.852 L/kg 1compartment NA NA Rat Human DTXSID0048925 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048925 TK.Half.Life NA 2.08 hours 1compartment NA NA Rat Human -DTXSID0048925 Css NA 0.08174 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048925 Css NA 0.6116 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048925 Css NA 0.06219 mg/L PBTK NA 50% Rat Human -DTXSID0048925 Css NA 0.393 mg/L PBTK NA 95% Rat Human -DTXSID0048927 Clint NA 89.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048927 Fup NA 0.124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048927 Vd NA 0.4927 L/kg 1compartment NA NA Human Human +DTXSID0048925 TK.Half.Life NA 1.772 hours 1compartment NA NA Rat Human +DTXSID0048925 Css NA 0.01501 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048925 Css NA 0.1005 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048925 Css NA 0.01216 mg/L PBTK NA 50% Rat Human +DTXSID0048925 Css NA 0.06946 mg/L PBTK NA 95% Rat Human +DTXSID0048927 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048927 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048927 Vd NA 0.3966 L/kg 1compartment NA NA Human Human DTXSID0048927 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048927 TK.Half.Life NA 0.5996 hours 1compartment NA NA Human Human -DTXSID0048927 Css NA 0.05685 mg/L 3compartmentss NA 50% Human Human -DTXSID0048927 Css NA 0.4878 mg/L 3compartmentss NA 95% Human Human -DTXSID0048927 Css NA 0.03585 mg/L PBTK NA 50% Human Human -DTXSID0048927 Css NA 0.2944 mg/L PBTK NA 95% Human Human -DTXSID0048927 Clint NA 89.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048927 Fup NA 0.124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048927 Vd NA 0.4263 L/kg 1compartment NA NA Rat Human +DTXSID0048927 TK.Half.Life NA 1.113 hours 1compartment NA NA Human Human +DTXSID0048927 Css NA 0.264 mg/L 3compartmentss NA 50% Human Human +DTXSID0048927 Css NA 1.593 mg/L 3compartmentss NA 95% Human Human +DTXSID0048927 Css NA 0.1778 mg/L PBTK NA 50% Human Human +DTXSID0048927 Css NA 1.002 mg/L PBTK NA 95% Human Human +DTXSID0048927 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048927 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048927 Vd NA 0.3905 L/kg 1compartment NA NA Rat Human DTXSID0048927 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048927 TK.Half.Life NA 0.2611 hours 1compartment NA NA Rat Human -DTXSID0048927 Css NA 0.0326 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048927 Css NA 0.2209 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048927 Css NA 0.01942 mg/L PBTK NA 50% Rat Human -DTXSID0048927 Css NA 0.1284 mg/L PBTK NA 95% Rat Human -DTXSID0048929 Clint NA 15.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048929 Fup NA 0.0707 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048929 Vd NA 2.949 L/kg 1compartment NA NA Human Human -DTXSID0048929 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID0048929 TK.Half.Life NA 39.23 hours 1compartment NA NA Human Human -DTXSID0048929 Css NA 1.618 mg/L 3compartmentss NA 50% Human Human -DTXSID0048929 Css NA 9.571 mg/L 3compartmentss NA 95% Human Human -DTXSID0048929 Css NA 1.128 mg/L PBTK NA 50% Human Human -DTXSID0048929 Css NA 6.455 mg/L PBTK NA 95% Human Human -DTXSID0048929 Clint NA 15.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048929 Fup NA 0.0707 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048929 Vd NA 2.219 L/kg 1compartment NA NA Rat Human -DTXSID0048929 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0048929 TK.Half.Life NA 6.876 hours 1compartment NA NA Rat Human -DTXSID0048929 Css NA 0.8958 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048929 Css NA 4.319 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048929 Css NA 0.5952 mg/L PBTK NA 50% Rat Human -DTXSID0048929 Css NA 2.797 mg/L PBTK NA 95% Rat Human -DTXSID0048971 Clint NA 42.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048971 Fup NA 0.0571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048971 Vd NA 0.3872 L/kg 1compartment NA NA Human Human +DTXSID0048927 TK.Half.Life NA 0.6296 hours 1compartment NA NA Rat Human +DTXSID0048927 Css NA 0.03131 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048927 Css NA 0.1378 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048927 Css NA 0.02092 mg/L PBTK NA 50% Rat Human +DTXSID0048927 Css NA 0.08373 mg/L PBTK NA 95% Rat Human +DTXSID0048929 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048929 Fup 0.0468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048929 Vd NA 2.088 L/kg 1compartment NA NA Human Human +DTXSID0048929 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0048929 TK.Half.Life NA 12.14 hours 1compartment NA NA Human Human +DTXSID0048929 Css NA 0.7626 mg/L 3compartmentss NA 50% Human Human +DTXSID0048929 Css NA 5.311 mg/L 3compartmentss NA 95% Human Human +DTXSID0048929 Css NA 0.4993 mg/L PBTK NA 50% Human Human +DTXSID0048929 Css NA 3.41 mg/L PBTK NA 95% Human Human +DTXSID0048929 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048929 Fup 0.0468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048929 Vd NA 1.574 L/kg 1compartment NA NA Rat Human +DTXSID0048929 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0048929 TK.Half.Life NA 3.888 hours 1compartment NA NA Rat Human +DTXSID0048929 Css NA 0.09685 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048929 Css NA 0.5723 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048929 Css NA 0.06269 mg/L PBTK NA 50% Rat Human +DTXSID0048929 Css NA 0.3562 mg/L PBTK NA 95% Rat Human +DTXSID0048971 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048971 Fup 0.0566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048971 Vd NA 0.7757 L/kg 1compartment NA NA Human Human DTXSID0048971 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048971 TK.Half.Life NA 0.9487 hours 1compartment NA NA Human Human -DTXSID0048971 Css NA 0.2818 mg/L 3compartmentss NA 50% Human Human -DTXSID0048971 Css NA 2.271 mg/L 3compartmentss NA 95% Human Human -DTXSID0048971 Css NA 0.1698 mg/L PBTK NA 50% Human Human -DTXSID0048971 Css NA 1.362 mg/L PBTK NA 95% Human Human -DTXSID0048971 Clint NA 42.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048971 Fup NA 0.0571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048971 Vd NA 0.3306 L/kg 1compartment NA NA Rat Human +DTXSID0048971 TK.Half.Life NA 8.318 hours 1compartment NA NA Human Human +DTXSID0048971 Css NA 1.694 mg/L 3compartmentss NA 50% Human Human +DTXSID0048971 Css NA 11.4 mg/L 3compartmentss NA 95% Human Human +DTXSID0048971 Css NA 1.047 mg/L PBTK NA 50% Human Human +DTXSID0048971 Css NA 6.773 mg/L PBTK NA 95% Human Human +DTXSID0048971 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048971 Fup 0.0566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048971 Vd NA 0.6002 L/kg 1compartment NA NA Rat Human DTXSID0048971 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048971 TK.Half.Life NA 0.4764 hours 1compartment NA NA Rat Human -DTXSID0048971 Css NA 0.1614 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048971 Css NA 1.062 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048971 Css NA 0.09102 mg/L PBTK NA 50% Rat Human -DTXSID0048971 Css NA 0.5918 mg/L PBTK NA 95% Rat Human -DTXSID0048973 Clint NA 17.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048973 Fup NA 0.063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048973 Vd NA 2.641 L/kg 1compartment NA NA Human Human -DTXSID0048973 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0048973 TK.Half.Life NA 22.55 hours 1compartment NA NA Human Human -DTXSID0048973 Css NA 1.087 mg/L 3compartmentss NA 50% Human Human -DTXSID0048973 Css NA 6.967 mg/L 3compartmentss NA 95% Human Human -DTXSID0048973 Css NA 0.742 mg/L PBTK NA 50% Human Human -DTXSID0048973 Css NA 4.611 mg/L PBTK NA 95% Human Human -DTXSID0048973 Clint NA 17.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048973 Fup NA 0.063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048973 Vd NA 1.982 L/kg 1compartment NA NA Rat Human -DTXSID0048973 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0048973 TK.Half.Life NA 5.177 hours 1compartment NA NA Rat Human -DTXSID0048973 Css NA 0.6042 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048973 Css NA 2.971 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048973 Css NA 0.3926 mg/L PBTK NA 50% Rat Human -DTXSID0048973 Css NA 1.853 mg/L PBTK NA 95% Rat Human -DTXSID0048975 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID0048971 TK.Half.Life NA 3.786 hours 1compartment NA NA Rat Human +DTXSID0048971 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048971 Css NA 1.082 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048971 Css NA 0.1249 mg/L PBTK NA 50% Rat Human +DTXSID0048971 Css NA 0.6189 mg/L PBTK NA 95% Rat Human +DTXSID0048973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048973 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048973 Vd NA 2.351 L/kg 1compartment NA NA Human Human +DTXSID0048973 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0048973 TK.Half.Life NA 17.52 hours 1compartment NA NA Human Human +DTXSID0048973 Css NA 0.9916 mg/L 3compartmentss NA 50% Human Human +DTXSID0048973 Css NA 7.277 mg/L 3compartmentss NA 95% Human Human +DTXSID0048973 Css NA 0.6576 mg/L PBTK NA 50% Human Human +DTXSID0048973 Css NA 4.594 mg/L PBTK NA 95% Human Human +DTXSID0048973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048973 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048973 Vd NA 1.758 L/kg 1compartment NA NA Rat Human +DTXSID0048973 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0048973 TK.Half.Life NA 4.81 hours 1compartment NA NA Rat Human +DTXSID0048973 Css NA 0.1293 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048973 Css NA 0.7767 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048973 Css NA 0.08394 mg/L PBTK NA 50% Rat Human +DTXSID0048973 Css NA 0.4826 mg/L PBTK NA 95% Rat Human +DTXSID0048975 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID0048975 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID0048975 Vd NA 0.5595 L/kg 1compartment NA NA Human Human DTXSID0048975 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048975 TK.Half.Life NA 5.844 hours 1compartment NA NA Human Human -DTXSID0048975 Css NA 1.254 mg/L 3compartmentss NA 50% Human Human -DTXSID0048975 Css NA 7.923 mg/L 3compartmentss NA 95% Human Human -DTXSID0048975 Css NA 0.9574 mg/L PBTK NA 50% Human Human -DTXSID0048975 Css NA 4.942 mg/L PBTK NA 95% Human Human -DTXSID0048975 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID0048975 TK.Half.Life NA 0.8329 hours 1compartment NA NA Human Human +DTXSID0048975 Css NA 0.06689 mg/L 3compartmentss NA 50% Human Human +DTXSID0048975 Css NA 0.6713 mg/L 3compartmentss NA 95% Human Human +DTXSID0048975 Css NA 0.0504 mg/L PBTK NA 50% Human Human +DTXSID0048975 Css NA 0.4374 mg/L PBTK NA 95% Human Human +DTXSID0048975 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID0048975 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID0048975 Vd NA 0.5806 L/kg 1compartment NA NA Rat Human DTXSID0048975 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048975 TK.Half.Life NA 2.065 hours 1compartment NA NA Rat Human -DTXSID0048975 Css NA 0.3318 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048975 Css NA 1.989 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048975 Css NA 0.2423 mg/L PBTK NA 50% Rat Human -DTXSID0048975 Css NA 1.153 mg/L PBTK NA 95% Rat Human -DTXSID0048977 Clint NA 1668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048977 Fup NA 0.037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048977 Vd NA 1.134 L/kg 1compartment NA NA Human Human -DTXSID0048977 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048977 TK.Half.Life NA 1.098 hours 1compartment NA NA Human Human -DTXSID0048977 Css NA 0.01129 mg/L 3compartmentss NA 50% Human Human -DTXSID0048977 Css NA 0.1059 mg/L 3compartmentss NA 95% Human Human -DTXSID0048977 Css NA 0.007026 mg/L PBTK NA 50% Human Human -DTXSID0048977 Css NA 0.06473 mg/L PBTK NA 95% Human Human -DTXSID0048977 Clint NA 1668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048977 Fup NA 0.037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048977 Vd NA 0.8489 L/kg 1compartment NA NA Rat Human -DTXSID0048977 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048977 TK.Half.Life NA 0.3685 hours 1compartment NA NA Rat Human -DTXSID0048977 Css NA 0.006544 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048977 Css NA 0.04923 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048977 Css NA 0.00381 mg/L PBTK NA 50% Rat Human -DTXSID0048977 Css NA 0.02738 mg/L PBTK NA 95% Rat Human -DTXSID0048979 Clint NA 6.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048979 Fup NA 0.1956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0048979 Vd NA 3.565 L/kg 1compartment NA NA Human Human +DTXSID0048975 TK.Half.Life NA 0.4627 hours 1compartment NA NA Rat Human +DTXSID0048975 Css NA 0.000729 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048975 Css NA 0.007845 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048975 Css NA 0.0005299 mg/L PBTK NA 50% Rat Human +DTXSID0048975 Css NA 0.004822 mg/L PBTK NA 95% Rat Human +DTXSID0048977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048977 Fup 0.0606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048977 Vd NA 2.936 L/kg 1compartment NA NA Human Human +DTXSID0048977 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0048977 TK.Half.Life NA 32.42 hours 1compartment NA NA Human Human +DTXSID0048977 Css NA 1.147 mg/L 3compartmentss NA 50% Human Human +DTXSID0048977 Css NA 8.01 mg/L 3compartmentss NA 95% Human Human +DTXSID0048977 Css NA 0.7913 mg/L PBTK NA 50% Human Human +DTXSID0048977 Css NA 5.326 mg/L PBTK NA 95% Human Human +DTXSID0048977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048977 Fup 0.0606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048977 Vd NA 2.201 L/kg 1compartment NA NA Rat Human +DTXSID0048977 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID0048977 TK.Half.Life NA 5.71 hours 1compartment NA NA Rat Human +DTXSID0048977 Css NA 0.05812 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048977 Css NA 0.4009 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048977 Css NA 0.03903 mg/L PBTK NA 50% Rat Human +DTXSID0048977 Css NA 0.2569 mg/L PBTK NA 95% Rat Human +DTXSID0048979 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048979 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0048979 Vd NA 1.782 L/kg 1compartment NA NA Human Human DTXSID0048979 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0048979 TK.Half.Life NA 12.31 hours 1compartment NA NA Human Human -DTXSID0048979 Css NA 0.2598 mg/L 3compartmentss NA 50% Human Human -DTXSID0048979 Css NA 1.623 mg/L 3compartmentss NA 95% Human Human -DTXSID0048979 Css NA 0.2613 mg/L PBTK NA 50% Human Human -DTXSID0048979 Css NA 1.412 mg/L PBTK NA 95% Human Human -DTXSID0048979 Clint NA 6.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048979 Fup NA 0.1956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0048979 Vd NA 3.345 L/kg 1compartment NA NA Rat Human +DTXSID0048979 TK.Half.Life NA 3.2 hours 1compartment NA NA Human Human +DTXSID0048979 Css NA 0.1221 mg/L 3compartmentss NA 50% Human Human +DTXSID0048979 Css NA 0.8926 mg/L 3compartmentss NA 95% Human Human +DTXSID0048979 Css NA 0.1105 mg/L PBTK NA 50% Human Human +DTXSID0048979 Css NA 0.6756 mg/L PBTK NA 95% Human Human +DTXSID0048979 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048979 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0048979 Vd NA 1.797 L/kg 1compartment NA NA Rat Human DTXSID0048979 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0048979 TK.Half.Life NA 5.536 hours 1compartment NA NA Rat Human -DTXSID0048979 Css NA 0.1314 mg/L 3compartmentss NA 50% Rat Human -DTXSID0048979 Css NA 0.625 mg/L 3compartmentss NA 95% Rat Human -DTXSID0048979 Css NA 0.1323 mg/L PBTK NA 50% Rat Human -DTXSID0048979 Css NA 0.5196 mg/L PBTK NA 95% Rat Human -DTXSID0049020 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049020 Fup NA 0.958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049020 Vd NA 1.312 L/kg 1compartment NA NA Human Human -DTXSID0049020 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049020 TK.Half.Life NA 8.864 hours 1compartment NA NA Human Human -DTXSID0049020 Css NA 0.7524 mg/L 3compartmentss NA 50% Human Human -DTXSID0049020 Css NA 2.723 mg/L 3compartmentss NA 95% Human Human -DTXSID0049020 Css NA 0.7118 mg/L PBTK NA 50% Human Human -DTXSID0049020 Css NA 2.076 mg/L PBTK NA 95% Human Human -DTXSID0049020 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049020 Fup NA 0.958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049020 Vd NA 1.379 L/kg 1compartment NA NA Rat Human -DTXSID0049020 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049020 TK.Half.Life NA 3.174 hours 1compartment NA NA Rat Human -DTXSID0049020 Css NA 0.1901 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049020 Css NA 0.6472 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049020 Css NA 0.1785 mg/L PBTK NA 50% Rat Human -DTXSID0049020 Css NA 0.4516 mg/L PBTK NA 95% Rat Human -DTXSID0049022 Clint NA 31.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049022 Fup NA 0.2546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049022 Vd NA 3.029 L/kg 1compartment NA NA Human Human +DTXSID0048979 TK.Half.Life NA 1.831 hours 1compartment NA NA Rat Human +DTXSID0048979 Css NA 0.01406 mg/L 3compartmentss NA 50% Rat Human +DTXSID0048979 Css NA 0.08347 mg/L 3compartmentss NA 95% Rat Human +DTXSID0048979 Css NA 0.01301 mg/L PBTK NA 50% Rat Human +DTXSID0048979 Css NA 0.05943 mg/L PBTK NA 95% Rat Human +DTXSID0049022 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049022 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049022 Vd NA 3.795 L/kg 1compartment NA NA Human Human DTXSID0049022 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049022 TK.Half.Life NA 2.95 hours 1compartment NA NA Human Human -DTXSID0049022 Css NA 0.04064 mg/L 3compartmentss NA 50% Human Human -DTXSID0049022 Css NA 0.3259 mg/L 3compartmentss NA 95% Human Human -DTXSID0049022 Css NA 0.0411 mg/L PBTK NA 50% Human Human -DTXSID0049022 Css NA 0.27 mg/L PBTK NA 95% Human Human -DTXSID0049022 Clint NA 31.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049022 Fup NA 0.2546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049022 Vd NA 2.97 L/kg 1compartment NA NA Rat Human +DTXSID0049022 TK.Half.Life NA 7.303 hours 1compartment NA NA Human Human +DTXSID0049022 Css NA 0.1112 mg/L 3compartmentss NA 50% Human Human +DTXSID0049022 Css NA 0.8715 mg/L 3compartmentss NA 95% Human Human +DTXSID0049022 Css NA 0.132 mg/L PBTK NA 50% Human Human +DTXSID0049022 Css NA 0.7868 mg/L PBTK NA 95% Human Human +DTXSID0049022 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049022 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049022 Vd NA 3.751 L/kg 1compartment NA NA Rat Human DTXSID0049022 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049022 TK.Half.Life NA 1.5 hours 1compartment NA NA Rat Human -DTXSID0049022 Css NA 0.0216 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049022 Css NA 0.1375 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049022 Css NA 0.02157 mg/L PBTK NA 50% Rat Human -DTXSID0049022 Css NA 0.1161 mg/L PBTK NA 95% Rat Human -DTXSID0049024 Clint NA 0.8145 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049024 Fup NA 0.8991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049024 Vd NA 1.137 L/kg 1compartment NA NA Human Human +DTXSID0049022 TK.Half.Life NA 3.849 hours 1compartment NA NA Rat Human +DTXSID0049022 Css NA 0.01256 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049022 Css NA 0.07289 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049022 Css NA 0.01555 mg/L PBTK NA 50% Rat Human +DTXSID0049022 Css NA 0.06424 mg/L PBTK NA 95% Rat Human +DTXSID0049024 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049024 Fup 0.636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049024 Vd NA 0.9182 L/kg 1compartment NA NA Human Human DTXSID0049024 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049024 TK.Half.Life NA 3.794 hours 1compartment NA NA Human Human -DTXSID0049024 Css NA 0.357 mg/L 3compartmentss NA 50% Human Human -DTXSID0049024 Css NA 1.587 mg/L 3compartmentss NA 95% Human Human -DTXSID0049024 Css NA 0.3179 mg/L PBTK NA 50% Human Human -DTXSID0049024 Css NA 1.155 mg/L PBTK NA 95% Human Human -DTXSID0049024 Clint NA 0.8145 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049024 Fup NA 0.8991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049024 Vd NA 1.094 L/kg 1compartment NA NA Rat Human +DTXSID0049024 TK.Half.Life NA 9.574 hours 1compartment NA NA Human Human +DTXSID0049024 Css NA 1.1 mg/L 3compartmentss NA 50% Human Human +DTXSID0049024 Css NA 7.36 mg/L 3compartmentss NA 95% Human Human +DTXSID0049024 Css NA 0.923 mg/L PBTK NA 50% Human Human +DTXSID0049024 Css NA 4.702 mg/L PBTK NA 95% Human Human +DTXSID0049024 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049024 Fup 0.636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049024 Vd NA 0.882 L/kg 1compartment NA NA Rat Human DTXSID0049024 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049024 TK.Half.Life NA 1.67 hours 1compartment NA NA Rat Human -DTXSID0049024 Css NA 0.1278 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049024 Css NA 0.4871 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049024 Css NA 0.1139 mg/L PBTK NA 50% Rat Human -DTXSID0049024 Css NA 0.3267 mg/L PBTK NA 95% Rat Human -DTXSID0049026 Clint NA 0.8356 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049026 Fup NA 0.1183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049026 Vd NA 1.014 L/kg 1compartment NA NA Human Human -DTXSID0049026 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0049026 TK.Half.Life NA 25.41 hours 1compartment NA NA Human Human -DTXSID0049026 Css NA 3.62 mg/L 3compartmentss NA 50% Human Human -DTXSID0049026 Css NA 17.98 mg/L 3compartmentss NA 95% Human Human -DTXSID0049026 Css NA 2.384 mg/L PBTK NA 50% Human Human -DTXSID0049026 Css NA 10.9 mg/L PBTK NA 95% Human Human -DTXSID0049026 Clint NA 0.8356 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049026 Fup NA 0.1183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049026 Vd NA 0.8054 L/kg 1compartment NA NA Rat Human -DTXSID0049026 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0049026 TK.Half.Life NA 8.982 hours 1compartment NA NA Rat Human -DTXSID0049026 Css NA 1.461 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049026 Css NA 6.066 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049026 Css NA 0.9084 mg/L PBTK NA 50% Rat Human -DTXSID0049026 Css NA 3.399 mg/L PBTK NA 95% Rat Human -DTXSID0049028 Clint NA 99.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049028 Fup NA 0.2875 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049028 Vd NA 0.819 L/kg 1compartment NA NA Human Human -DTXSID0049028 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049028 TK.Half.Life NA 0.7235 hours 1compartment NA NA Human Human -DTXSID0049028 Css NA 0.01675 mg/L 3compartmentss NA 50% Human Human -DTXSID0049028 Css NA 0.127 mg/L 3compartmentss NA 95% Human Human -DTXSID0049028 Css NA 0.01212 mg/L PBTK NA 50% Human Human -DTXSID0049028 Css NA 0.0858 mg/L PBTK NA 95% Human Human -DTXSID0049028 Clint NA 99.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049028 Fup NA 0.2875 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049028 Vd NA 0.7264 L/kg 1compartment NA NA Rat Human +DTXSID0049024 TK.Half.Life NA 3.075 hours 1compartment NA NA Rat Human +DTXSID0049024 Css NA 0.06679 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049024 Css NA 0.4261 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049024 Css NA 0.05607 mg/L PBTK NA 50% Rat Human +DTXSID0049024 Css NA 0.2622 mg/L PBTK NA 95% Rat Human +DTXSID0049026 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049026 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049026 Vd NA 1.209 L/kg 1compartment NA NA Human Human +DTXSID0049026 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0049026 TK.Half.Life NA 6.484 hours 1compartment NA NA Human Human +DTXSID0049026 Css NA 0.6692 mg/L 3compartmentss NA 50% Human Human +DTXSID0049026 Css NA 4.634 mg/L 3compartmentss NA 95% Human Human +DTXSID0049026 Css NA 0.4524 mg/L PBTK NA 50% Human Human +DTXSID0049026 Css NA 2.891 mg/L PBTK NA 95% Human Human +DTXSID0049026 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049026 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049026 Vd NA 0.951 L/kg 1compartment NA NA Rat Human +DTXSID0049026 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0049026 TK.Half.Life NA 2.74 hours 1compartment NA NA Rat Human +DTXSID0049026 Css NA 0.08244 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049026 Css NA 0.4142 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049026 Css NA 0.05407 mg/L PBTK NA 50% Rat Human +DTXSID0049026 Css NA 0.2473 mg/L PBTK NA 95% Rat Human +DTXSID0049028 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049028 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049028 Vd NA 0.9293 L/kg 1compartment NA NA Human Human +DTXSID0049028 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0049028 TK.Half.Life NA 15.04 hours 1compartment NA NA Human Human +DTXSID0049028 Css NA 1.67 mg/L 3compartmentss NA 50% Human Human +DTXSID0049028 Css NA 7.474 mg/L 3compartmentss NA 95% Human Human +DTXSID0049028 Css NA 1.312 mg/L PBTK NA 50% Human Human +DTXSID0049028 Css NA 4.857 mg/L PBTK NA 95% Human Human +DTXSID0049028 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049028 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049028 Vd NA 0.8418 L/kg 1compartment NA NA Rat Human DTXSID0049028 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049028 TK.Half.Life NA 0.2997 hours 1compartment NA NA Rat Human -DTXSID0049028 Css NA 0.009202 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049028 Css NA 0.05724 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049028 Css NA 0.006392 mg/L PBTK NA 50% Rat Human -DTXSID0049028 Css NA 0.03716 mg/L PBTK NA 95% Rat Human -DTXSID0049070 Clint NA 10.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049070 Fup NA 0.4805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049070 Vd NA 2.194 L/kg 1compartment NA NA Human Human +DTXSID0049028 TK.Half.Life NA 4.472 hours 1compartment NA NA Rat Human +DTXSID0049028 Css NA 0.1047 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049028 Css NA 0.4234 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049028 Css NA 0.08169 mg/L PBTK NA 50% Rat Human +DTXSID0049028 Css NA 0.2656 mg/L PBTK NA 95% Rat Human +DTXSID0049070 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049070 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049070 Vd NA 1.901 L/kg 1compartment NA NA Human Human DTXSID0049070 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049070 TK.Half.Life NA 2.565 hours 1compartment NA NA Human Human -DTXSID0049070 Css NA 0.06374 mg/L 3compartmentss NA 50% Human Human -DTXSID0049070 Css NA 0.5748 mg/L 3compartmentss NA 95% Human Human -DTXSID0049070 Css NA 0.0654 mg/L PBTK NA 50% Human Human -DTXSID0049070 Css NA 0.4565 mg/L PBTK NA 95% Human Human -DTXSID0049070 Clint NA 10.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049070 Fup NA 0.4805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049070 Vd NA 2.204 L/kg 1compartment NA NA Rat Human +DTXSID0049070 TK.Half.Life NA 3.031 hours 1compartment NA NA Human Human +DTXSID0049070 Css NA 0.05225 mg/L 3compartmentss NA 50% Human Human +DTXSID0049070 Css NA 0.486 mg/L 3compartmentss NA 95% Human Human +DTXSID0049070 Css NA 0.05102 mg/L PBTK NA 50% Human Human +DTXSID0049070 Css NA 0.3714 mg/L PBTK NA 95% Human Human +DTXSID0049070 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049070 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049070 Vd NA 1.908 L/kg 1compartment NA NA Rat Human DTXSID0049070 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049070 TK.Half.Life NA 1.433 hours 1compartment NA NA Rat Human -DTXSID0049070 Css NA 0.03199 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049070 Css NA 0.2271 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049070 Css NA 0.03212 mg/L PBTK NA 50% Rat Human -DTXSID0049070 Css NA 0.1691 mg/L PBTK NA 95% Rat Human -DTXSID0049072 Clint NA 8.207 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049072 Fup NA 0.5902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049072 Vd NA 4.041 L/kg 1compartment NA NA Human Human +DTXSID0049070 TK.Half.Life NA 1.716 hours 1compartment NA NA Rat Human +DTXSID0049070 Css NA 0.0004637 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049070 Css NA 0.004113 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049070 Css NA 0.000445 mg/L PBTK NA 50% Rat Human +DTXSID0049070 Css NA 0.003019 mg/L PBTK NA 95% Rat Human +DTXSID0049072 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049072 Fup 0.417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049072 Vd NA 1.565 L/kg 1compartment NA NA Human Human DTXSID0049072 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049072 TK.Half.Life NA 4.404 hours 1compartment NA NA Human Human -DTXSID0049072 Css NA 0.05669 mg/L 3compartmentss NA 50% Human Human -DTXSID0049072 Css NA 0.6429 mg/L 3compartmentss NA 95% Human Human -DTXSID0049072 Css NA 0.07344 mg/L PBTK NA 50% Human Human -DTXSID0049072 Css NA 0.5574 mg/L PBTK NA 95% Human Human -DTXSID0049072 Clint NA 8.207 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049072 Fup NA 0.5902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049072 Vd NA 4.092 L/kg 1compartment NA NA Rat Human +DTXSID0049072 TK.Half.Life NA 2.927 hours 1compartment NA NA Human Human +DTXSID0049072 Css NA 0.1325 mg/L 3compartmentss NA 50% Human Human +DTXSID0049072 Css NA 0.9421 mg/L 3compartmentss NA 95% Human Human +DTXSID0049072 Css NA 0.1154 mg/L PBTK NA 50% Human Human +DTXSID0049072 Css NA 0.6941 mg/L PBTK NA 95% Human Human +DTXSID0049072 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049072 Fup 0.417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049072 Vd NA 1.577 L/kg 1compartment NA NA Rat Human DTXSID0049072 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049072 TK.Half.Life NA 2.445 hours 1compartment NA NA Rat Human -DTXSID0049072 Css NA 0.0274 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049072 Css NA 0.268 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049072 Css NA 0.03592 mg/L PBTK NA 50% Rat Human -DTXSID0049072 Css NA 0.2075 mg/L PBTK NA 95% Rat Human -DTXSID0049074 Clint NA 41.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049074 Fup NA 0.1981 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049074 Vd NA 2.791 L/kg 1compartment NA NA Human Human -DTXSID0049074 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049074 TK.Half.Life NA 6.515 hours 1compartment NA NA Human Human -DTXSID0049074 Css NA 0.19 mg/L 3compartmentss NA 50% Human Human -DTXSID0049074 Css NA 1.206 mg/L 3compartmentss NA 95% Human Human -DTXSID0049074 Css NA 0.1366 mg/L PBTK NA 50% Human Human -DTXSID0049074 Css NA 0.848 mg/L PBTK NA 95% Human Human -DTXSID0049074 Clint NA 41.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049074 Fup NA 0.1981 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049074 Vd NA 2.116 L/kg 1compartment NA NA Rat Human +DTXSID0049072 TK.Half.Life NA 1.672 hours 1compartment NA NA Rat Human +DTXSID0049072 Css NA 0.01485 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049072 Css NA 0.08732 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049072 Css NA 0.01323 mg/L PBTK NA 50% Rat Human +DTXSID0049072 Css NA 0.06116 mg/L PBTK NA 95% Rat Human +DTXSID0049074 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049074 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049074 Vd NA 0.7399 L/kg 1compartment NA NA Human Human +DTXSID0049074 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0049074 TK.Half.Life NA 14.96 hours 1compartment NA NA Human Human +DTXSID0049074 Css NA 1.206 mg/L 3compartmentss NA 50% Human Human +DTXSID0049074 Css NA 5.305 mg/L 3compartmentss NA 95% Human Human +DTXSID0049074 Css NA 0.8872 mg/L PBTK NA 50% Human Human +DTXSID0049074 Css NA 3.417 mg/L PBTK NA 95% Human Human +DTXSID0049074 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049074 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049074 Vd NA 0.7367 L/kg 1compartment NA NA Rat Human DTXSID0049074 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049074 TK.Half.Life NA 1.596 hours 1compartment NA NA Rat Human -DTXSID0049074 Css NA 0.1049 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049074 Css NA 0.5549 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049074 Css NA 0.07272 mg/L PBTK NA 50% Rat Human -DTXSID0049074 Css NA 0.3694 mg/L PBTK NA 95% Rat Human -DTXSID0049076 Clint NA 1.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049076 Fup NA 0.0122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049076 Vd NA 0.2402 L/kg 1compartment NA NA Human Human -DTXSID0049076 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID0049076 TK.Half.Life NA 38.44 hours 1compartment NA NA Human Human -DTXSID0049076 Css NA 28.68 mg/L 3compartmentss NA 50% Human Human -DTXSID0049076 Css NA 195.5 mg/L 3compartmentss NA 95% Human Human -DTXSID0049076 Css NA 16.88 mg/L PBTK NA 50% Human Human -DTXSID0049076 Css NA 112.6 mg/L PBTK NA 95% Human Human -DTXSID0049076 Clint NA 1.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049076 Fup NA 0.0122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049076 Vd NA 0.2161 L/kg 1compartment NA NA Rat Human -DTXSID0049076 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0049076 TK.Half.Life NA 18.36 hours 1compartment NA NA Rat Human -DTXSID0049076 Css NA 12.67 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049076 Css NA 75.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049076 Css NA 6.958 mg/L PBTK NA 50% Rat Human -DTXSID0049076 Css NA 40.72 mg/L PBTK NA 95% Rat Human -DTXSID0049078 Clint NA 8.091 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049078 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049078 Vd NA 0.5514 L/kg 1compartment NA NA Human Human -DTXSID0049078 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID0049078 TK.Half.Life NA 36.97 hours 1compartment NA NA Human Human -DTXSID0049078 Css NA 12.39 mg/L 3compartmentss NA 50% Human Human -DTXSID0049078 Css NA 109.6 mg/L 3compartmentss NA 95% Human Human -DTXSID0049078 Css NA 7.366 mg/L PBTK NA 50% Human Human -DTXSID0049078 Css NA 63.27 mg/L PBTK NA 95% Human Human -DTXSID0049078 Clint NA 8.091 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049078 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049078 Vd NA 0.4128 L/kg 1compartment NA NA Rat Human -DTXSID0049078 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID0049078 TK.Half.Life NA 17.57 hours 1compartment NA NA Rat Human -DTXSID0049078 Css NA 6.952 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049078 Css NA 48.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049078 Css NA 3.827 mg/L PBTK NA 50% Rat Human -DTXSID0049078 Css NA 26.11 mg/L PBTK NA 95% Rat Human -DTXSID0049234 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049234 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049234 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID0049234 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0049234 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID0049234 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID0049234 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID0049234 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID0049234 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID0049234 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049234 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049234 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID0049234 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049234 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID0049234 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049234 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049234 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID0049234 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID0049280 Clint NA 11.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049280 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049280 Vd NA 1171 L/kg 1compartment NA NA Human Human -DTXSID0049280 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID0049280 TK.Half.Life NA 66010 hours 1compartment NA NA Human Human -DTXSID0049280 Css NA 0.02464 mg/L 3compartmentss NA 50% Human Human -DTXSID0049280 Css NA 0.1482 mg/L 3compartmentss NA 95% Human Human -DTXSID0049280 Css NA 4.704 mg/L PBTK NA 50% Human Human -DTXSID0049280 Css NA 25.12 mg/L PBTK NA 95% Human Human -DTXSID0049280 Clint NA 11.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049280 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049280 Vd NA 1076 L/kg 1compartment NA NA Rat Human -DTXSID0049280 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID0049280 TK.Half.Life NA 10440 hours 1compartment NA NA Rat Human -DTXSID0049280 Css NA 0.01242 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049280 Css NA 0.05376 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049280 Css NA 2.529 mg/L PBTK NA 50% Rat Human -DTXSID0049280 Css NA 10.77 mg/L PBTK NA 95% Rat Human -DTXSID0049286 Clint NA 23.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049286 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049286 Vd NA 1.238 L/kg 1compartment NA NA Human Human +DTXSID0049074 TK.Half.Life NA 5.067 hours 1compartment NA NA Rat Human +DTXSID0049074 Css NA 0.006428 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049074 Css NA 0.02913 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049074 Css NA 0.004558 mg/L PBTK NA 50% Rat Human +DTXSID0049074 Css NA 0.01791 mg/L PBTK NA 95% Rat Human +DTXSID0049076 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049076 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049076 Vd NA 0.2968 L/kg 1compartment NA NA Human Human +DTXSID0049076 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0049076 TK.Half.Life NA 1.555 hours 1compartment NA NA Human Human +DTXSID0049076 Css NA 0.8003 mg/L 3compartmentss NA 50% Human Human +DTXSID0049076 Css NA 7.613 mg/L 3compartmentss NA 95% Human Human +DTXSID0049076 Css NA 0.4828 mg/L PBTK NA 50% Human Human +DTXSID0049076 Css NA 4.52 mg/L PBTK NA 95% Human Human +DTXSID0049076 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049076 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049076 Vd NA 0.2693 L/kg 1compartment NA NA Rat Human +DTXSID0049076 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0049076 TK.Half.Life NA 0.8957 hours 1compartment NA NA Rat Human +DTXSID0049076 Css NA 0.107 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049076 Css NA 0.7951 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049076 Css NA 0.06238 mg/L PBTK NA 50% Rat Human +DTXSID0049076 Css NA 0.4526 mg/L PBTK NA 95% Rat Human +DTXSID0049078 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049078 Fup 0.038 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049078 Vd NA 1.203 L/kg 1compartment NA NA Human Human +DTXSID0049078 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0049078 TK.Half.Life NA 6.614 hours 1compartment NA NA Human Human +DTXSID0049078 Css NA 0.808 mg/L 3compartmentss NA 50% Human Human +DTXSID0049078 Css NA 7.291 mg/L 3compartmentss NA 95% Human Human +DTXSID0049078 Css NA 0.5019 mg/L PBTK NA 50% Human Human +DTXSID0049078 Css NA 4.384 mg/L PBTK NA 95% Human Human +DTXSID0049078 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049078 Fup 0.038 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049078 Vd NA 0.8996 L/kg 1compartment NA NA Rat Human +DTXSID0049078 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0049078 TK.Half.Life NA 2.735 hours 1compartment NA NA Rat Human +DTXSID0049078 Css NA 0.1046 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049078 Css NA 0.7278 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049078 Css NA 0.06339 mg/L PBTK NA 50% Rat Human +DTXSID0049078 Css NA 0.4242 mg/L PBTK NA 95% Rat Human +DTXSID0049280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049280 Fup 0.031 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049280 Vd NA 3.123 L/kg 1compartment NA NA Human Human +DTXSID0049280 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID0049280 TK.Half.Life NA 89.3 hours 1compartment NA NA Human Human +DTXSID0049280 Css NA 1.848 mg/L 3compartmentss NA 50% Human Human +DTXSID0049280 Css NA 12.27 mg/L 3compartmentss NA 95% Human Human +DTXSID0049280 Css NA 1.28 mg/L PBTK NA 50% Human Human +DTXSID0049280 Css NA 8.292 mg/L PBTK NA 95% Human Human +DTXSID0049280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049280 Fup 0.031 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049280 Vd NA 2.341 L/kg 1compartment NA NA Rat Human +DTXSID0049280 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID0049280 TK.Half.Life NA 11.96 hours 1compartment NA NA Rat Human +DTXSID0049280 Css NA 0.02019 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049280 Css NA 0.1226 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049280 Css NA 0.0135 mg/L PBTK NA 50% Rat Human +DTXSID0049280 Css NA 0.08133 mg/L PBTK NA 95% Rat Human +DTXSID0049286 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049286 Fup 0.861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049286 Vd NA 0.5688 L/kg 1compartment NA NA Human Human DTXSID0049286 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049286 TK.Half.Life NA 0.8267 hours 1compartment NA NA Human Human -DTXSID0049286 Css NA 0.02048 mg/L 3compartmentss NA 50% Human Human -DTXSID0049286 Css NA 0.2741 mg/L 3compartmentss NA 95% Human Human -DTXSID0049286 Css NA 0.01827 mg/L PBTK NA 50% Human Human -DTXSID0049286 Css NA 0.2141 mg/L PBTK NA 95% Human Human -DTXSID0049286 Clint NA 23.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049286 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049286 Vd NA 1.156 L/kg 1compartment NA NA Rat Human +DTXSID0049286 TK.Half.Life NA 4.273 hours 1compartment NA NA Human Human +DTXSID0049286 Css NA 0.9756 mg/L 3compartmentss NA 50% Human Human +DTXSID0049286 Css NA 5.644 mg/L 3compartmentss NA 95% Human Human +DTXSID0049286 Css NA 0.7598 mg/L PBTK NA 50% Human Human +DTXSID0049286 Css NA 3.604 mg/L PBTK NA 95% Human Human +DTXSID0049286 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049286 Fup 0.861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049286 Vd NA 0.6083 L/kg 1compartment NA NA Rat Human DTXSID0049286 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049286 TK.Half.Life NA 0.3623 hours 1compartment NA NA Rat Human -DTXSID0049286 Css NA 0.01019 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049286 Css NA 0.1053 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049286 Css NA 0.009098 mg/L PBTK NA 50% Rat Human -DTXSID0049286 Css NA 0.07744 mg/L PBTK NA 95% Rat Human -DTXSID0049288 Clint NA 2.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049288 Fup NA 0.8017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049288 Vd NA 4.756 L/kg 1compartment NA NA Human Human +DTXSID0049286 TK.Half.Life NA 1.558 hours 1compartment NA NA Rat Human +DTXSID0049286 Css NA 0.05878 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049286 Css NA 0.3211 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049286 Css NA 0.04543 mg/L PBTK NA 50% Rat Human +DTXSID0049286 Css NA 0.1956 mg/L PBTK NA 95% Rat Human +DTXSID0049288 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049288 Fup 0.501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049288 Vd NA 3.38 L/kg 1compartment NA NA Human Human DTXSID0049288 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049288 TK.Half.Life NA 9.084 hours 1compartment NA NA Human Human -DTXSID0049288 Css NA 0.1247 mg/L 3compartmentss NA 50% Human Human -DTXSID0049288 Css NA 1.201 mg/L 3compartmentss NA 95% Human Human -DTXSID0049288 Css NA 0.1809 mg/L PBTK NA 50% Human Human -DTXSID0049288 Css NA 1.032 mg/L PBTK NA 95% Human Human -DTXSID0049288 Clint NA 2.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049288 Fup NA 0.8017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049288 Vd NA 4.863 L/kg 1compartment NA NA Rat Human +DTXSID0049288 TK.Half.Life NA 2.475 hours 1compartment NA NA Human Human +DTXSID0049288 Css NA 0.02382 mg/L 3compartmentss NA 50% Human Human +DTXSID0049288 Css NA 0.249 mg/L 3compartmentss NA 95% Human Human +DTXSID0049288 Css NA 0.0285 mg/L PBTK NA 50% Human Human +DTXSID0049288 Css NA 0.226 mg/L PBTK NA 95% Human Human +DTXSID0049288 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049288 Fup 0.501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049288 Vd NA 3.433 L/kg 1compartment NA NA Rat Human DTXSID0049288 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049288 TK.Half.Life NA 5.034 hours 1compartment NA NA Rat Human -DTXSID0049288 Css NA 0.05018 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049288 Css NA 0.4705 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049288 Css NA 0.07674 mg/L PBTK NA 50% Rat Human -DTXSID0049288 Css NA 0.3627 mg/L PBTK NA 95% Rat Human -DTXSID0049311 Clint NA 23.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049311 Fup NA 0.0935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049311 Vd NA 0.9764 L/kg 1compartment NA NA Human Human +DTXSID0049288 TK.Half.Life NA 1.343 hours 1compartment NA NA Rat Human +DTXSID0049288 Css NA 0.002768 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049288 Css NA 0.02582 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049288 Css NA 0.00351 mg/L PBTK NA 50% Rat Human +DTXSID0049288 Css NA 0.02223 mg/L PBTK NA 95% Rat Human +DTXSID0049311 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049311 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049311 Vd NA 1.309 L/kg 1compartment NA NA Human Human DTXSID0049311 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049311 TK.Half.Life NA 2.532 hours 1compartment NA NA Human Human -DTXSID0049311 Css NA 0.2878 mg/L 3compartmentss NA 50% Human Human -DTXSID0049311 Css NA 2.361 mg/L 3compartmentss NA 95% Human Human -DTXSID0049311 Css NA 0.1858 mg/L PBTK NA 50% Human Human -DTXSID0049311 Css NA 1.434 mg/L PBTK NA 95% Human Human -DTXSID0049311 Clint NA 23.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049311 Fup NA 0.0935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049311 Vd NA 0.7679 L/kg 1compartment NA NA Rat Human +DTXSID0049311 TK.Half.Life NA 2.579 hours 1compartment NA NA Human Human +DTXSID0049311 Css NA 0.1558 mg/L 3compartmentss NA 50% Human Human +DTXSID0049311 Css NA 1.121 mg/L 3compartmentss NA 95% Human Human +DTXSID0049311 Css NA 0.1073 mg/L PBTK NA 50% Human Human +DTXSID0049311 Css NA 0.7246 mg/L PBTK NA 95% Human Human +DTXSID0049311 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049311 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049311 Vd NA 1.033 L/kg 1compartment NA NA Rat Human DTXSID0049311 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049311 TK.Half.Life NA 1.11 hours 1compartment NA NA Rat Human -DTXSID0049311 Css NA 0.1629 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049311 Css NA 0.9611 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049311 Css NA 0.09866 mg/L PBTK NA 50% Rat Human -DTXSID0049311 Css NA 0.5567 mg/L PBTK NA 95% Rat Human -DTXSID0049313 Clint NA 0.5116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049313 Fup NA 0.3991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049313 Vd NA 0.7716 L/kg 1compartment NA NA Human Human +DTXSID0049311 TK.Half.Life NA 1.052 hours 1compartment NA NA Rat Human +DTXSID0049311 Css NA 0.02016 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049311 Css NA 0.1111 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049311 Css NA 0.01379 mg/L PBTK NA 50% Rat Human +DTXSID0049311 Css NA 0.07142 mg/L PBTK NA 95% Rat Human +DTXSID0049313 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049313 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049313 Vd NA 0.6342 L/kg 1compartment NA NA Human Human DTXSID0049313 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049313 TK.Half.Life NA 7.012 hours 1compartment NA NA Human Human -DTXSID0049313 Css NA 0.9624 mg/L 3compartmentss NA 50% Human Human -DTXSID0049313 Css NA 4.478 mg/L 3compartmentss NA 95% Human Human -DTXSID0049313 Css NA 0.733 mg/L PBTK NA 50% Human Human -DTXSID0049313 Css NA 2.921 mg/L PBTK NA 95% Human Human -DTXSID0049313 Clint NA 0.5116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049313 Fup NA 0.3991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049313 Vd NA 0.7228 L/kg 1compartment NA NA Rat Human +DTXSID0049313 TK.Half.Life NA 0.9323 hours 1compartment NA NA Human Human +DTXSID0049313 Css NA 0.0861 mg/L 3compartmentss NA 50% Human Human +DTXSID0049313 Css NA 0.6245 mg/L 3compartmentss NA 95% Human Human +DTXSID0049313 Css NA 0.05953 mg/L PBTK NA 50% Human Human +DTXSID0049313 Css NA 0.4014 mg/L PBTK NA 95% Human Human +DTXSID0049313 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049313 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049313 Vd NA 0.5816 L/kg 1compartment NA NA Rat Human DTXSID0049313 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049313 TK.Half.Life NA 2.854 hours 1compartment NA NA Rat Human -DTXSID0049313 Css NA 0.343 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049313 Css NA 1.376 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049313 Css NA 0.252 mg/L PBTK NA 50% Rat Human -DTXSID0049313 Css NA 0.828 mg/L PBTK NA 95% Rat Human -DTXSID0049315 Clint NA 14.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049315 Fup NA 0.087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049315 Vd NA 1.757 L/kg 1compartment NA NA Human Human +DTXSID0049313 TK.Half.Life NA 0.4609 hours 1compartment NA NA Rat Human +DTXSID0049313 Css NA 0.01082 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049313 Css NA 0.06174 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049313 Css NA 0.007428 mg/L PBTK NA 50% Rat Human +DTXSID0049313 Css NA 0.03916 mg/L PBTK NA 95% Rat Human +DTXSID0049315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049315 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0049315 Vd NA 1.562 L/kg 1compartment NA NA Human Human DTXSID0049315 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049315 TK.Half.Life NA 8.05 hours 1compartment NA NA Human Human -DTXSID0049315 Css NA 0.5812 mg/L 3compartmentss NA 50% Human Human -DTXSID0049315 Css NA 4.11 mg/L 3compartmentss NA 95% Human Human -DTXSID0049315 Css NA 0.3894 mg/L PBTK NA 50% Human Human -DTXSID0049315 Css NA 2.581 mg/L PBTK NA 95% Human Human -DTXSID0049315 Clint NA 14.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049315 Fup NA 0.087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049315 Vd NA 1.332 L/kg 1compartment NA NA Rat Human +DTXSID0049315 TK.Half.Life NA 4.618 hours 1compartment NA NA Human Human +DTXSID0049315 Css NA 0.3253 mg/L 3compartmentss NA 50% Human Human +DTXSID0049315 Css NA 2.465 mg/L 3compartmentss NA 95% Human Human +DTXSID0049315 Css NA 0.2144 mg/L PBTK NA 50% Human Human +DTXSID0049315 Css NA 1.555 mg/L PBTK NA 95% Human Human +DTXSID0049315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049315 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0049315 Vd NA 1.193 L/kg 1compartment NA NA Rat Human DTXSID0049315 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049315 TK.Half.Life NA 2.889 hours 1compartment NA NA Rat Human -DTXSID0049315 Css NA 0.3244 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049315 Css NA 1.751 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049315 Css NA 0.203 mg/L PBTK NA 50% Rat Human -DTXSID0049315 Css NA 1.043 mg/L PBTK NA 95% Rat Human -DTXSID0049361 Clint NA 0.1128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049361 Fup NA 0.7117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049361 Vd NA 0.9425 L/kg 1compartment NA NA Human Human -DTXSID0049361 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049361 TK.Half.Life NA 7.367 hours 1compartment NA NA Human Human -DTXSID0049361 Css NA 0.8513 mg/L 3compartmentss NA 50% Human Human -DTXSID0049361 Css NA 5.578 mg/L 3compartmentss NA 95% Human Human -DTXSID0049361 Css NA 0.7258 mg/L PBTK NA 50% Human Human -DTXSID0049361 Css NA 3.601 mg/L PBTK NA 95% Human Human -DTXSID0049361 Clint NA 0.1128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049361 Fup NA 0.7117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049361 Vd NA 0.9193 L/kg 1compartment NA NA Rat Human -DTXSID0049361 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049361 TK.Half.Life NA 2.624 hours 1compartment NA NA Rat Human -DTXSID0049361 Css NA 0.2412 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049361 Css NA 1.66 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049361 Css NA 0.2001 mg/L PBTK NA 50% Rat Human -DTXSID0049361 Css NA 0.9948 mg/L PBTK NA 95% Rat Human -DTXSID0049365 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049365 Fup NA 0.4256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0049365 Vd NA 0.4693 L/kg 1compartment NA NA Human Human -DTXSID0049365 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0049365 TK.Half.Life NA 7.138 hours 1compartment NA NA Human Human -DTXSID0049365 Css NA 1.74 mg/L 3compartmentss NA 50% Human Human -DTXSID0049365 Css NA 7.87 mg/L 3compartmentss NA 95% Human Human -DTXSID0049365 Css NA 1.266 mg/L PBTK NA 50% Human Human -DTXSID0049365 Css NA 4.941 mg/L PBTK NA 95% Human Human -DTXSID0049365 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049365 Fup NA 0.4256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0049365 Vd NA 0.4698 L/kg 1compartment NA NA Rat Human -DTXSID0049365 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0049365 TK.Half.Life NA 2.434 hours 1compartment NA NA Rat Human -DTXSID0049365 Css NA 0.4689 mg/L 3compartmentss NA 50% Rat Human -DTXSID0049365 Css NA 1.808 mg/L 3compartmentss NA 95% Rat Human -DTXSID0049365 Css NA 0.3277 mg/L PBTK NA 50% Rat Human -DTXSID0049365 Css NA 1.065 mg/L PBTK NA 95% Rat Human -DTXSID0050423 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0050423 Fup NA 0.0948 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0050423 Vd NA 0.2715 L/kg 1compartment NA NA Human Human -DTXSID0050423 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0050423 TK.Half.Life NA 18.54 hours 1compartment NA NA Human Human -DTXSID0050423 Css NA 10.88 mg/L 3compartmentss NA 50% Human Human -DTXSID0050423 Css NA 49.36 mg/L 3compartmentss NA 95% Human Human -DTXSID0050423 Css NA 6.648 mg/L PBTK NA 50% Human Human -DTXSID0050423 Css NA 28.91 mg/L PBTK NA 95% Human Human -DTXSID0050423 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0050423 Fup NA 0.0948 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0050423 Vd NA 0.2656 L/kg 1compartment NA NA Rat Human +DTXSID0049315 TK.Half.Life NA 1.76 hours 1compartment NA NA Rat Human +DTXSID0049315 Css NA 0.04187 mg/L 3compartmentss NA 50% Rat Human +DTXSID0049315 Css NA 0.2494 mg/L 3compartmentss NA 95% Rat Human +DTXSID0049315 Css NA 0.02727 mg/L PBTK NA 50% Rat Human +DTXSID0049315 Css NA 0.1546 mg/L PBTK NA 95% Rat Human +DTXSID0050423 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0050423 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0050423 Vd NA 0.2752 L/kg 1compartment NA NA Human Human +DTXSID0050423 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0050423 TK.Half.Life NA 1.61 hours 1compartment NA NA Human Human +DTXSID0050423 Css NA 0.44 mg/L 3compartmentss NA 50% Human Human +DTXSID0050423 Css NA 3.361 mg/L 3compartmentss NA 95% Human Human +DTXSID0050423 Css NA 0.2712 mg/L PBTK NA 50% Human Human +DTXSID0050423 Css NA 2.01 mg/L PBTK NA 95% Human Human +DTXSID0050423 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0050423 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0050423 Vd NA 0.2709 L/kg 1compartment NA NA Rat Human DTXSID0050423 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0050423 TK.Half.Life NA 6.178 hours 1compartment NA NA Rat Human -DTXSID0050423 Css NA 3.052 mg/L 3compartmentss NA 50% Rat Human -DTXSID0050423 Css NA 11.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID0050423 Css NA 1.752 mg/L PBTK NA 50% Rat Human -DTXSID0050423 Css NA 6.535 mg/L PBTK NA 95% Rat Human -DTXSID0050425 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0050425 Fup NA 0.8264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0050425 Vd NA 0.6342 L/kg 1compartment NA NA Human Human +DTXSID0050423 TK.Half.Life NA 0.9604 hours 1compartment NA NA Rat Human +DTXSID0050423 Css NA 0.004571 mg/L 3compartmentss NA 50% Rat Human +DTXSID0050423 Css NA 0.02766 mg/L 3compartmentss NA 95% Rat Human +DTXSID0050423 Css NA 0.002662 mg/L PBTK NA 50% Rat Human +DTXSID0050423 Css NA 0.01555 mg/L PBTK NA 95% Rat Human +DTXSID0050425 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0050425 Fup 0.676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0050425 Vd NA 0.5782 L/kg 1compartment NA NA Human Human DTXSID0050425 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0050425 TK.Half.Life NA 4.965 hours 1compartment NA NA Human Human -DTXSID0050425 Css NA 1.01 mg/L 3compartmentss NA 50% Human Human -DTXSID0050425 Css NA 5.708 mg/L 3compartmentss NA 95% Human Human -DTXSID0050425 Css NA 0.8084 mg/L PBTK NA 50% Human Human -DTXSID0050425 Css NA 3.663 mg/L PBTK NA 95% Human Human -DTXSID0050425 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0050425 Fup NA 0.8264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0050425 Vd NA 0.6754 L/kg 1compartment NA NA Rat Human +DTXSID0050425 TK.Half.Life NA 5.532 hours 1compartment NA NA Human Human +DTXSID0050425 Css NA 0.9927 mg/L 3compartmentss NA 50% Human Human +DTXSID0050425 Css NA 6.288 mg/L 3compartmentss NA 95% Human Human +DTXSID0050425 Css NA 0.7746 mg/L PBTK NA 50% Human Human +DTXSID0050425 Css NA 3.949 mg/L PBTK NA 95% Human Human +DTXSID0050425 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0050425 Fup 0.676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0050425 Vd NA 0.6123 L/kg 1compartment NA NA Rat Human DTXSID0050425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0050425 TK.Half.Life NA 1.802 hours 1compartment NA NA Rat Human -DTXSID0050425 Css NA 0.257 mg/L 3compartmentss NA 50% Rat Human -DTXSID0050425 Css NA 1.469 mg/L 3compartmentss NA 95% Rat Human -DTXSID0050425 Css NA 0.1986 mg/L PBTK NA 50% Rat Human -DTXSID0050425 Css NA 0.8714 mg/L PBTK NA 95% Rat Human -DTXSID0051447 Clint NA 260.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051447 Fup NA 0.0401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051447 Vd NA 2.011 L/kg 1compartment NA NA Human Human +DTXSID0050425 TK.Half.Life NA 1.997 hours 1compartment NA NA Rat Human +DTXSID0050425 Css NA 0.01899 mg/L 3compartmentss NA 50% Rat Human +DTXSID0050425 Css NA 0.1504 mg/L 3compartmentss NA 95% Rat Human +DTXSID0050425 Css NA 0.01405 mg/L PBTK NA 50% Rat Human +DTXSID0050425 Css NA 0.09382 mg/L PBTK NA 95% Rat Human +DTXSID0051447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051447 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051447 Vd NA 1.961 L/kg 1compartment NA NA Human Human DTXSID0051447 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0051447 TK.Half.Life NA 2.668 hours 1compartment NA NA Human Human -DTXSID0051447 Css NA 0.07779 mg/L 3compartmentss NA 50% Human Human -DTXSID0051447 Css NA 0.646 mg/L 3compartmentss NA 95% Human Human -DTXSID0051447 Css NA 0.05072 mg/L PBTK NA 50% Human Human -DTXSID0051447 Css NA 0.3993 mg/L PBTK NA 95% Human Human -DTXSID0051447 Clint NA 260.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051447 Fup NA 0.0401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051447 Vd NA 1.503 L/kg 1compartment NA NA Rat Human +DTXSID0051447 TK.Half.Life NA 12.95 hours 1compartment NA NA Human Human +DTXSID0051447 Css NA 0.9233 mg/L 3compartmentss NA 50% Human Human +DTXSID0051447 Css NA 7.197 mg/L 3compartmentss NA 95% Human Human +DTXSID0051447 Css NA 0.596 mg/L PBTK NA 50% Human Human +DTXSID0051447 Css NA 4.491 mg/L PBTK NA 95% Human Human +DTXSID0051447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051447 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051447 Vd NA 1.465 L/kg 1compartment NA NA Rat Human DTXSID0051447 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0051447 TK.Half.Life NA 0.874 hours 1compartment NA NA Rat Human -DTXSID0051447 Css NA 0.0439 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051447 Css NA 0.3089 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051447 Css NA 0.02701 mg/L PBTK NA 50% Rat Human -DTXSID0051447 Css NA 0.183 mg/L PBTK NA 95% Rat Human -DTXSID0051493 Clint NA 0.7661 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051493 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051493 Vd NA 1.377 L/kg 1compartment NA NA Human Human +DTXSID0051447 TK.Half.Life NA 4.266 hours 1compartment NA NA Rat Human +DTXSID0051447 Css NA 0.1205 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051447 Css NA 0.7294 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051447 Css NA 0.0765 mg/L PBTK NA 50% Rat Human +DTXSID0051447 Css NA 0.4441 mg/L PBTK NA 95% Rat Human +DTXSID0051493 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051493 Fup 0.788 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051493 Vd NA 1.105 L/kg 1compartment NA NA Human Human DTXSID0051493 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0051493 TK.Half.Life NA 4.161 hours 1compartment NA NA Human Human -DTXSID0051493 Css NA 0.3312 mg/L 3compartmentss NA 50% Human Human -DTXSID0051493 Css NA 2.335 mg/L 3compartmentss NA 95% Human Human -DTXSID0051493 Css NA 0.3056 mg/L PBTK NA 50% Human Human -DTXSID0051493 Css NA 1.612 mg/L PBTK NA 95% Human Human -DTXSID0051493 Clint NA 0.7661 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051493 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051493 Vd NA 1.401 L/kg 1compartment NA NA Rat Human +DTXSID0051493 TK.Half.Life NA 9.082 hours 1compartment NA NA Human Human +DTXSID0051493 Css NA 0.912 mg/L 3compartmentss NA 50% Human Human +DTXSID0051493 Css NA 5.797 mg/L 3compartmentss NA 95% Human Human +DTXSID0051493 Css NA 0.7962 mg/L PBTK NA 50% Human Human +DTXSID0051493 Css NA 3.835 mg/L PBTK NA 95% Human Human +DTXSID0051493 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051493 Fup 0.788 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051493 Vd NA 1.127 L/kg 1compartment NA NA Rat Human DTXSID0051493 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0051493 TK.Half.Life NA 1.96 hours 1compartment NA NA Rat Human -DTXSID0051493 Css NA 0.1176 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051493 Css NA 0.7973 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051493 Css NA 0.1084 mg/L PBTK NA 50% Rat Human -DTXSID0051493 Css NA 0.4971 mg/L PBTK NA 95% Rat Human -DTXSID0051497 Clint NA 2.191 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051497 Fup NA 0.3017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051497 Vd NA 2.545 L/kg 1compartment NA NA Human Human -DTXSID0051497 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID0051497 TK.Half.Life NA 30.01 hours 1compartment NA NA Human Human -DTXSID0051497 Css NA 1.3 mg/L 3compartmentss NA 50% Human Human -DTXSID0051497 Css NA 5.417 mg/L 3compartmentss NA 95% Human Human -DTXSID0051497 Css NA 0.9798 mg/L PBTK NA 50% Human Human -DTXSID0051497 Css NA 3.742 mg/L PBTK NA 95% Human Human -DTXSID0051497 Clint NA 2.191 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051497 Fup NA 0.3017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051497 Vd NA 1.954 L/kg 1compartment NA NA Rat Human -DTXSID0051497 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0051497 TK.Half.Life NA 6.796 hours 1compartment NA NA Rat Human -DTXSID0051497 Css NA 0.6008 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051497 Css NA 1.825 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051497 Css NA 0.4358 mg/L PBTK NA 50% Rat Human -DTXSID0051497 Css NA 1.173 mg/L PBTK NA 95% Rat Human -DTXSID0051499 Clint NA 3.603 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051499 Fup NA 0.8415 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051499 Vd NA 1.508 L/kg 1compartment NA NA Human Human +DTXSID0051493 TK.Half.Life NA 3.154 hours 1compartment NA NA Rat Human +DTXSID0051493 Css NA 0.05402 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051493 Css NA 0.3426 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051493 Css NA 0.04748 mg/L PBTK NA 50% Rat Human +DTXSID0051493 Css NA 0.2159 mg/L PBTK NA 95% Rat Human +DTXSID0051497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051497 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051497 Vd NA 2.502 L/kg 1compartment NA NA Human Human +DTXSID0051497 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0051497 TK.Half.Life NA 7.777 hours 1compartment NA NA Human Human +DTXSID0051497 Css NA 0.2907 mg/L 3compartmentss NA 50% Human Human +DTXSID0051497 Css NA 1.93 mg/L 3compartmentss NA 95% Human Human +DTXSID0051497 Css NA 0.2057 mg/L PBTK NA 50% Human Human +DTXSID0051497 Css NA 1.322 mg/L PBTK NA 95% Human Human +DTXSID0051497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051497 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051497 Vd NA 1.898 L/kg 1compartment NA NA Rat Human +DTXSID0051497 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0051497 TK.Half.Life NA 2.112 hours 1compartment NA NA Rat Human +DTXSID0051497 Css NA 0.03707 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051497 Css NA 0.1858 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051497 Css NA 0.02597 mg/L PBTK NA 50% Rat Human +DTXSID0051497 Css NA 0.1272 mg/L PBTK NA 95% Rat Human +DTXSID0051499 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051499 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051499 Vd NA 0.9806 L/kg 1compartment NA NA Human Human DTXSID0051499 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0051499 TK.Half.Life NA 2.414 hours 1compartment NA NA Human Human -DTXSID0051499 Css NA 0.1338 mg/L 3compartmentss NA 50% Human Human -DTXSID0051499 Css NA 1.063 mg/L 3compartmentss NA 95% Human Human -DTXSID0051499 Css NA 0.1237 mg/L PBTK NA 50% Human Human -DTXSID0051499 Css NA 0.7703 mg/L PBTK NA 95% Human Human -DTXSID0051499 Clint NA 3.603 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051499 Fup NA 0.8415 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051499 Vd NA 1.374 L/kg 1compartment NA NA Rat Human +DTXSID0051499 TK.Half.Life NA 1.13 hours 1compartment NA NA Human Human +DTXSID0051499 Css NA 0.05286 mg/L 3compartmentss NA 50% Human Human +DTXSID0051499 Css NA 0.4031 mg/L 3compartmentss NA 95% Human Human +DTXSID0051499 Css NA 0.04037 mg/L PBTK NA 50% Human Human +DTXSID0051499 Css NA 0.2796 mg/L PBTK NA 95% Human Human +DTXSID0051499 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051499 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051499 Vd NA 0.8781 L/kg 1compartment NA NA Rat Human DTXSID0051499 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0051499 TK.Half.Life NA 1.11 hours 1compartment NA NA Rat Human -DTXSID0051499 Css NA 0.06024 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051499 Css NA 0.4297 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051499 Css NA 0.05495 mg/L PBTK NA 50% Rat Human -DTXSID0051499 Css NA 0.2793 mg/L PBTK NA 95% Rat Human -DTXSID0051732 Clint NA 18.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051732 Fup NA 0.2581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051732 Vd NA 2.507 L/kg 1compartment NA NA Human Human +DTXSID0051499 TK.Half.Life NA 0.5188 hours 1compartment NA NA Rat Human +DTXSID0051499 Css NA 0.006492 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051499 Css NA 0.03846 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051499 Css NA 0.004994 mg/L PBTK NA 50% Rat Human +DTXSID0051499 Css NA 0.02642 mg/L PBTK NA 95% Rat Human +DTXSID0051524 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051524 Fup 0.227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051524 Vd NA 1.191 L/kg 1compartment NA NA Human Human +DTXSID0051524 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0051524 TK.Half.Life NA 1.871 hours 1compartment NA NA Human Human +DTXSID0051524 Css NA 0.09708 mg/L 3compartmentss NA 50% Human Human +DTXSID0051524 Css NA 0.6774 mg/L 3compartmentss NA 95% Human Human +DTXSID0051524 Css NA 0.06992 mg/L PBTK NA 50% Human Human +DTXSID0051524 Css NA 0.4561 mg/L PBTK NA 95% Human Human +DTXSID0051524 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051524 Fup 0.227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051524 Vd NA 0.9713 L/kg 1compartment NA NA Rat Human +DTXSID0051524 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0051524 TK.Half.Life NA 0.7894 hours 1compartment NA NA Rat Human +DTXSID0051524 Css NA 0.01254 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051524 Css NA 0.06961 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051524 Css NA 0.00891 mg/L PBTK NA 50% Rat Human +DTXSID0051524 Css NA 0.0456 mg/L PBTK NA 95% Rat Human +DTXSID0051526 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051526 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051526 Vd NA 1.053 L/kg 1compartment NA NA Human Human +DTXSID0051526 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0051526 TK.Half.Life NA 1.413 hours 1compartment NA NA Human Human +DTXSID0051526 Css NA 0.07184 mg/L 3compartmentss NA 50% Human Human +DTXSID0051526 Css NA 0.5356 mg/L 3compartmentss NA 95% Human Human +DTXSID0051526 Css NA 0.05298 mg/L PBTK NA 50% Human Human +DTXSID0051526 Css NA 0.3648 mg/L PBTK NA 95% Human Human +DTXSID0051526 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051526 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051526 Vd NA 0.8929 L/kg 1compartment NA NA Rat Human +DTXSID0051526 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0051526 TK.Half.Life NA 0.62 hours 1compartment NA NA Rat Human +DTXSID0051526 Css NA 0.008955 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051526 Css NA 0.05098 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051526 Css NA 0.00659 mg/L PBTK NA 50% Rat Human +DTXSID0051526 Css NA 0.03396 mg/L PBTK NA 95% Rat Human +DTXSID0051528 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051528 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051528 Vd NA 1.039 L/kg 1compartment NA NA Human Human +DTXSID0051528 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0051528 TK.Half.Life NA 1.094 hours 1compartment NA NA Human Human +DTXSID0051528 Css NA 0.04388 mg/L 3compartmentss NA 50% Human Human +DTXSID0051528 Css NA 0.3678 mg/L 3compartmentss NA 95% Human Human +DTXSID0051528 Css NA 0.03458 mg/L PBTK NA 50% Human Human +DTXSID0051528 Css NA 0.2557 mg/L PBTK NA 95% Human Human +DTXSID0051528 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051528 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051528 Vd NA 0.9257 L/kg 1compartment NA NA Rat Human +DTXSID0051528 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0051528 TK.Half.Life NA 0.4909 hours 1compartment NA NA Rat Human +DTXSID0051528 Css NA 0.005386 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051528 Css NA 0.03405 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051528 Css NA 0.004293 mg/L PBTK NA 50% Rat Human +DTXSID0051528 Css NA 0.02403 mg/L PBTK NA 95% Rat Human +DTXSID0051732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051732 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051732 Vd NA 2.019 L/kg 1compartment NA NA Human Human DTXSID0051732 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0051732 TK.Half.Life NA 6.267 hours 1compartment NA NA Human Human -DTXSID0051732 Css NA 0.213 mg/L 3compartmentss NA 50% Human Human -DTXSID0051732 Css NA 1.289 mg/L 3compartmentss NA 95% Human Human -DTXSID0051732 Css NA 0.1576 mg/L PBTK NA 50% Human Human -DTXSID0051732 Css NA 0.9208 mg/L PBTK NA 95% Human Human -DTXSID0051732 Clint NA 18.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051732 Fup NA 0.2581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051732 Vd NA 1.92 L/kg 1compartment NA NA Rat Human +DTXSID0051732 TK.Half.Life NA 4.702 hours 1compartment NA NA Human Human +DTXSID0051732 Css NA 0.2002 mg/L 3compartmentss NA 50% Human Human +DTXSID0051732 Css NA 1.293 mg/L 3compartmentss NA 95% Human Human +DTXSID0051732 Css NA 0.142 mg/L PBTK NA 50% Human Human +DTXSID0051732 Css NA 0.8683 mg/L PBTK NA 95% Human Human +DTXSID0051732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051732 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051732 Vd NA 1.548 L/kg 1compartment NA NA Rat Human DTXSID0051732 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0051732 TK.Half.Life NA 1.751 hours 1compartment NA NA Rat Human -DTXSID0051732 Css NA 0.1147 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051732 Css NA 0.5477 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051732 Css NA 0.08161 mg/L PBTK NA 50% Rat Human -DTXSID0051732 Css NA 0.3721 mg/L PBTK NA 95% Rat Human -DTXSID0051738 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051738 Fup NA 0.4088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051738 Vd NA 2.894 L/kg 1compartment NA NA Human Human -DTXSID0051738 Days.Css NA 58 Days PBTK NA NA Human Human -DTXSID0051738 TK.Half.Life NA 267.5 hours 1compartment NA NA Human Human -DTXSID0051738 Css NA 9.996 mg/L 3compartmentss NA 50% Human Human -DTXSID0051738 Css NA 29.17 mg/L 3compartmentss NA 95% Human Human -DTXSID0051738 Css NA 7.508 mg/L PBTK NA 50% Human Human -DTXSID0051738 Css NA 19.58 mg/L PBTK NA 95% Human Human -DTXSID0051738 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051738 Fup NA 0.4088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051738 Vd NA 2.208 L/kg 1compartment NA NA Rat Human -DTXSID0051738 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID0051738 TK.Half.Life NA 25.65 hours 1compartment NA NA Rat Human -DTXSID0051738 Css NA 2.684 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051738 Css NA 6.383 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051738 Css NA 1.945 mg/L PBTK NA 50% Rat Human -DTXSID0051738 Css NA 4.017 mg/L PBTK NA 95% Rat Human +DTXSID0051732 TK.Half.Life NA 1.581 hours 1compartment NA NA Rat Human +DTXSID0051732 Css NA 0.02545 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051732 Css NA 0.1272 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051732 Css NA 0.01781 mg/L PBTK NA 50% Rat Human +DTXSID0051732 Css NA 0.08491 mg/L PBTK NA 95% Rat Human DTXSID0051782 Clint NA 1.051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0051782 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051782 Vd NA 0.863 L/kg 1compartment NA NA Human Human +DTXSID0051782 Vd NA 0.867 L/kg 1compartment NA NA Human Human DTXSID0051782 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0051782 TK.Half.Life NA 2.244 hours 1compartment NA NA Human Human -DTXSID0051782 Css NA 0.3031 mg/L 3compartmentss NA 50% Human Human -DTXSID0051782 Css NA 2.082 mg/L 3compartmentss NA 95% Human Human -DTXSID0051782 Css NA 0.2588 mg/L PBTK NA 50% Human Human -DTXSID0051782 Css NA 1.389 mg/L PBTK NA 95% Human Human +DTXSID0051782 TK.Half.Life NA 2.254 hours 1compartment NA NA Human Human +DTXSID0051782 Css NA 0.2868 mg/L 3compartmentss NA 50% Human Human +DTXSID0051782 Css NA 2.084 mg/L 3compartmentss NA 95% Human Human +DTXSID0051782 Css NA 0.2452 mg/L PBTK NA 50% Human Human +DTXSID0051782 Css NA 1.38 mg/L PBTK NA 95% Human Human DTXSID0051782 Clint NA 1.051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0051782 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051782 Vd NA 0.8796 L/kg 1compartment NA NA Rat Human +DTXSID0051782 Vd NA 0.8835 L/kg 1compartment NA NA Rat Human DTXSID0051782 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0051782 TK.Half.Life NA 1.098 hours 1compartment NA NA Rat Human -DTXSID0051782 Css NA 0.1127 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051782 Css NA 0.7563 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051782 Css NA 0.09528 mg/L PBTK NA 50% Rat Human -DTXSID0051782 Css NA 0.4567 mg/L PBTK NA 95% Rat Human -DTXSID0051863 Clint NA 66.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051863 Fup NA 0.6164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051863 Vd NA 0.7926 L/kg 1compartment NA NA Human Human +DTXSID0051782 TK.Half.Life NA 1.103 hours 1compartment NA NA Rat Human +DTXSID0051782 Css NA 0.02528 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051782 Css NA 0.1599 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051782 Css NA 0.02205 mg/L PBTK NA 50% Rat Human +DTXSID0051782 Css NA 0.1016 mg/L PBTK NA 95% Rat Human +DTXSID0051863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051863 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051863 Vd NA 0.7359 L/kg 1compartment NA NA Human Human DTXSID0051863 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0051863 TK.Half.Life NA 0.5696 hours 1compartment NA NA Human Human -DTXSID0051863 Css NA 0.01181 mg/L 3compartmentss NA 50% Human Human -DTXSID0051863 Css NA 0.1298 mg/L 3compartmentss NA 95% Human Human -DTXSID0051863 Css NA 0.009465 mg/L PBTK NA 50% Human Human -DTXSID0051863 Css NA 0.08647 mg/L PBTK NA 95% Human Human -DTXSID0051863 Clint NA 66.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051863 Fup NA 0.6164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051863 Vd NA 0.7829 L/kg 1compartment NA NA Rat Human +DTXSID0051863 TK.Half.Life NA 5.94 hours 1compartment NA NA Human Human +DTXSID0051863 Css NA 0.8443 mg/L 3compartmentss NA 50% Human Human +DTXSID0051863 Css NA 4.905 mg/L 3compartmentss NA 95% Human Human +DTXSID0051863 Css NA 0.6942 mg/L PBTK NA 50% Human Human +DTXSID0051863 Css NA 3.227 mg/L PBTK NA 95% Human Human +DTXSID0051863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051863 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051863 Vd NA 0.761 L/kg 1compartment NA NA Rat Human DTXSID0051863 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0051863 TK.Half.Life NA 0.258 hours 1compartment NA NA Rat Human -DTXSID0051863 Css NA 0.006146 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051863 Css NA 0.05867 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051863 Css NA 0.004816 mg/L PBTK NA 50% Rat Human -DTXSID0051863 Css NA 0.03821 mg/L PBTK NA 95% Rat Human -DTXSID0051944 Clint NA 0.01571 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051944 Fup NA 0.996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051944 Vd NA 0.8892 L/kg 1compartment NA NA Human Human +DTXSID0051863 TK.Half.Life NA 2.09 hours 1compartment NA NA Rat Human +DTXSID0051863 Css NA 0.01577 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051863 Css NA 0.1208 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051863 Css NA 0.0123 mg/L PBTK NA 50% Rat Human +DTXSID0051863 Css NA 0.07838 mg/L PBTK NA 95% Rat Human +DTXSID0051942 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051942 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051942 Vd NA 1.092 L/kg 1compartment NA NA Human Human +DTXSID0051942 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID0051942 TK.Half.Life NA 26.64 hours 1compartment NA NA Human Human +DTXSID0051942 Css NA 2.593 mg/L 3compartmentss NA 50% Human Human +DTXSID0051942 Css NA 10.18 mg/L 3compartmentss NA 95% Human Human +DTXSID0051942 Css NA 1.935 mg/L PBTK NA 50% Human Human +DTXSID0051942 Css NA 6.651 mg/L PBTK NA 95% Human Human +DTXSID0051942 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051942 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051942 Vd NA 0.9226 L/kg 1compartment NA NA Rat Human +DTXSID0051942 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0051942 TK.Half.Life NA 7.063 hours 1compartment NA NA Rat Human +DTXSID0051942 Css NA 0.1654 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051942 Css NA 0.5479 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051942 Css NA 0.1225 mg/L PBTK NA 50% Rat Human +DTXSID0051942 Css NA 0.3422 mg/L PBTK NA 95% Rat Human +DTXSID0051944 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051944 Fup 0.846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051944 Vd NA 0.8075 L/kg 1compartment NA NA Human Human DTXSID0051944 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0051944 TK.Half.Life NA 5.654 hours 1compartment NA NA Human Human -DTXSID0051944 Css NA 0.8106 mg/L 3compartmentss NA 50% Human Human -DTXSID0051944 Css NA 4.78 mg/L 3compartmentss NA 95% Human Human -DTXSID0051944 Css NA 0.7009 mg/L PBTK NA 50% Human Human -DTXSID0051944 Css NA 3.217 mg/L PBTK NA 95% Human Human -DTXSID0051944 Clint NA 0.01571 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051944 Fup NA 0.996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051944 Vd NA 0.9113 L/kg 1compartment NA NA Rat Human +DTXSID0051944 TK.Half.Life NA 6.194 hours 1compartment NA NA Human Human +DTXSID0051944 Css NA 0.7969 mg/L 3compartmentss NA 50% Human Human +DTXSID0051944 Css NA 4.972 mg/L 3compartmentss NA 95% Human Human +DTXSID0051944 Css NA 0.669 mg/L PBTK NA 50% Human Human +DTXSID0051944 Css NA 3.271 mg/L PBTK NA 95% Human Human +DTXSID0051944 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051944 Fup 0.846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051944 Vd NA 0.8266 L/kg 1compartment NA NA Rat Human DTXSID0051944 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0051944 TK.Half.Life NA 1.995 hours 1compartment NA NA Rat Human -DTXSID0051944 Css NA 0.2088 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051944 Css NA 1.262 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051944 Css NA 0.1761 mg/L PBTK NA 50% Rat Human -DTXSID0051944 Css NA 0.7692 mg/L PBTK NA 95% Rat Human -DTXSID0051996 Clint NA 16.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051996 Fup NA 0.2532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0051996 Vd NA 1.797 L/kg 1compartment NA NA Human Human +DTXSID0051944 TK.Half.Life NA 2.157 hours 1compartment NA NA Rat Human +DTXSID0051944 Css NA 0.01478 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051944 Css NA 0.1105 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051944 Css NA 0.01204 mg/L PBTK NA 50% Rat Human +DTXSID0051944 Css NA 0.07347 mg/L PBTK NA 95% Rat Human +DTXSID0051946 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051946 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051946 Vd NA 0.7727 L/kg 1compartment NA NA Human Human +DTXSID0051946 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0051946 TK.Half.Life NA 8.137 hours 1compartment NA NA Human Human +DTXSID0051946 Css NA 1.151 mg/L 3compartmentss NA 50% Human Human +DTXSID0051946 Css NA 7.938 mg/L 3compartmentss NA 95% Human Human +DTXSID0051946 Css NA 0.9392 mg/L PBTK NA 50% Human Human +DTXSID0051946 Css NA 5.046 mg/L PBTK NA 95% Human Human +DTXSID0051946 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051946 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051946 Vd NA 0.7673 L/kg 1compartment NA NA Rat Human +DTXSID0051946 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0051946 TK.Half.Life NA 2.734 hours 1compartment NA NA Rat Human +DTXSID0051946 Css NA 0.0702 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051946 Css NA 0.4558 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051946 Css NA 0.05692 mg/L PBTK NA 50% Rat Human +DTXSID0051946 Css NA 0.2785 mg/L PBTK NA 95% Rat Human +DTXSID0051996 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051996 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0051996 Vd NA 1.41 L/kg 1compartment NA NA Human Human DTXSID0051996 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0051996 TK.Half.Life NA 3.409 hours 1compartment NA NA Human Human -DTXSID0051996 Css NA 0.1417 mg/L 3compartmentss NA 50% Human Human -DTXSID0051996 Css NA 0.9186 mg/L 3compartmentss NA 95% Human Human -DTXSID0051996 Css NA 0.1057 mg/L PBTK NA 50% Human Human -DTXSID0051996 Css NA 0.6464 mg/L PBTK NA 95% Human Human -DTXSID0051996 Clint NA 16.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051996 Fup NA 0.2532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0051996 Vd NA 1.412 L/kg 1compartment NA NA Rat Human +DTXSID0051996 TK.Half.Life NA 3.172 hours 1compartment NA NA Human Human +DTXSID0051996 Css NA 0.2094 mg/L 3compartmentss NA 50% Human Human +DTXSID0051996 Css NA 1.682 mg/L 3compartmentss NA 95% Human Human +DTXSID0051996 Css NA 0.1412 mg/L PBTK NA 50% Human Human +DTXSID0051996 Css NA 1.059 mg/L PBTK NA 95% Human Human +DTXSID0051996 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051996 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0051996 Vd NA 1.096 L/kg 1compartment NA NA Rat Human DTXSID0051996 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0051996 TK.Half.Life NA 1.253 hours 1compartment NA NA Rat Human -DTXSID0051996 Css NA 0.07747 mg/L 3compartmentss NA 50% Rat Human -DTXSID0051996 Css NA 0.3704 mg/L 3compartmentss NA 95% Rat Human -DTXSID0051996 Css NA 0.05498 mg/L PBTK NA 50% Rat Human -DTXSID0051996 Css NA 0.2485 mg/L PBTK NA 95% Rat Human -DTXSID0052043 Clint NA 0.863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052043 Fup NA 0.7149 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052043 Vd NA 1.042 L/kg 1compartment NA NA Human Human +DTXSID0051996 TK.Half.Life NA 1.261 hours 1compartment NA NA Rat Human +DTXSID0051996 Css NA 0.02696 mg/L 3compartmentss NA 50% Rat Human +DTXSID0051996 Css NA 0.159 mg/L 3compartmentss NA 95% Rat Human +DTXSID0051996 Css NA 0.01784 mg/L PBTK NA 50% Rat Human +DTXSID0051996 Css NA 0.09909 mg/L PBTK NA 95% Rat Human +DTXSID0052043 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052043 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052043 Vd NA 0.9689 L/kg 1compartment NA NA Human Human DTXSID0052043 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052043 TK.Half.Life NA 4.151 hours 1compartment NA NA Human Human -DTXSID0052043 Css NA 0.4194 mg/L 3compartmentss NA 50% Human Human -DTXSID0052043 Css NA 2.899 mg/L 3compartmentss NA 95% Human Human -DTXSID0052043 Css NA 0.3615 mg/L PBTK NA 50% Human Human -DTXSID0052043 Css NA 1.903 mg/L PBTK NA 95% Human Human -DTXSID0052043 Clint NA 0.863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052043 Fup NA 0.7149 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052043 Vd NA 1.025 L/kg 1compartment NA NA Rat Human +DTXSID0052043 TK.Half.Life NA 8.993 hours 1compartment NA NA Human Human +DTXSID0052043 Css NA 1.016 mg/L 3compartmentss NA 50% Human Human +DTXSID0052043 Css NA 6.692 mg/L 3compartmentss NA 95% Human Human +DTXSID0052043 Css NA 0.863 mg/L PBTK NA 50% Human Human +DTXSID0052043 Css NA 4.357 mg/L PBTK NA 95% Human Human +DTXSID0052043 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052043 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052043 Vd NA 0.9623 L/kg 1compartment NA NA Rat Human DTXSID0052043 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052043 TK.Half.Life NA 1.915 hours 1compartment NA NA Rat Human -DTXSID0052043 Css NA 0.1543 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052043 Css NA 1.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052043 Css NA 0.1314 mg/L PBTK NA 50% Rat Human -DTXSID0052043 Css NA 0.652 mg/L PBTK NA 95% Rat Human +DTXSID0052043 TK.Half.Life NA 3.018 hours 1compartment NA NA Rat Human +DTXSID0052043 Css NA 0.06019 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052043 Css NA 0.3858 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052043 Css NA 0.05158 mg/L PBTK NA 50% Rat Human +DTXSID0052043 Css NA 0.2404 mg/L PBTK NA 95% Rat Human +DTXSID0052045 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052045 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052045 Vd NA 2.905 L/kg 1compartment NA NA Human Human +DTXSID0052045 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0052045 TK.Half.Life NA 13.87 hours 1compartment NA NA Human Human +DTXSID0052045 Css NA 0.469 mg/L 3compartmentss NA 50% Human Human +DTXSID0052045 Css NA 2.994 mg/L 3compartmentss NA 95% Human Human +DTXSID0052045 Css NA 0.3351 mg/L PBTK NA 50% Human Human +DTXSID0052045 Css NA 2.078 mg/L PBTK NA 95% Human Human +DTXSID0052045 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052045 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052045 Vd NA 2.192 L/kg 1compartment NA NA Rat Human +DTXSID0052045 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0052045 TK.Half.Life NA 2.787 hours 1compartment NA NA Rat Human +DTXSID0052045 Css NA 0.06008 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052045 Css NA 0.2952 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052045 Css NA 0.04264 mg/L PBTK NA 50% Rat Human +DTXSID0052045 Css NA 0.2036 mg/L PBTK NA 95% Rat Human DTXSID0052124 Clint NA 1.151 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0052124 Fup NA 0.7477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052124 Vd NA 1.686 L/kg 1compartment NA NA Human Human +DTXSID0052124 Vd NA 1.898 L/kg 1compartment NA NA Human Human DTXSID0052124 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052124 TK.Half.Life NA 5.398 hours 1compartment NA NA Human Human -DTXSID0052124 Css NA 0.3118 mg/L 3compartmentss NA 50% Human Human -DTXSID0052124 Css NA 2.197 mg/L 3compartmentss NA 95% Human Human -DTXSID0052124 Css NA 0.3006 mg/L PBTK NA 50% Human Human -DTXSID0052124 Css NA 1.534 mg/L PBTK NA 95% Human Human +DTXSID0052124 TK.Half.Life NA 6.064 hours 1compartment NA NA Human Human +DTXSID0052124 Css NA 0.2536 mg/L 3compartmentss NA 50% Human Human +DTXSID0052124 Css NA 1.848 mg/L 3compartmentss NA 95% Human Human +DTXSID0052124 Css NA 0.2518 mg/L PBTK NA 50% Human Human +DTXSID0052124 Css NA 1.316 mg/L PBTK NA 95% Human Human DTXSID0052124 Clint NA 1.151 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0052124 Fup NA 0.7477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052124 Vd NA 1.717 L/kg 1compartment NA NA Rat Human +DTXSID0052124 Vd NA 1.928 L/kg 1compartment NA NA Rat Human DTXSID0052124 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052124 TK.Half.Life NA 2.72 hours 1compartment NA NA Rat Human -DTXSID0052124 Css NA 0.1171 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052124 Css NA 0.8999 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052124 Css NA 0.1125 mg/L PBTK NA 50% Rat Human -DTXSID0052124 Css NA 0.5567 mg/L PBTK NA 95% Rat Human -DTXSID0052463 Clint NA 16.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052463 Fup NA 0.047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052463 Vd NA 1.72 L/kg 1compartment NA NA Human Human +DTXSID0052124 TK.Half.Life NA 3.052 hours 1compartment NA NA Rat Human +DTXSID0052124 Css NA 0.006934 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052124 Css NA 0.06849 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052124 Css NA 0.006776 mg/L PBTK NA 50% Rat Human +DTXSID0052124 Css NA 0.04783 mg/L PBTK NA 95% Rat Human +DTXSID0052463 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052463 Fup 0.0312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052463 Vd NA 1.338 L/kg 1compartment NA NA Human Human DTXSID0052463 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052463 TK.Half.Life NA 11.16 hours 1compartment NA NA Human Human -DTXSID0052463 Css NA 0.9289 mg/L 3compartmentss NA 50% Human Human -DTXSID0052463 Css NA 6.782 mg/L 3compartmentss NA 95% Human Human -DTXSID0052463 Css NA 0.5955 mg/L PBTK NA 50% Human Human -DTXSID0052463 Css NA 4.184 mg/L PBTK NA 95% Human Human -DTXSID0052463 Clint NA 16.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052463 Fup NA 0.047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052463 Vd NA 1.289 L/kg 1compartment NA NA Rat Human +DTXSID0052463 TK.Half.Life NA 8.668 hours 1compartment NA NA Human Human +DTXSID0052463 Css NA 0.9546 mg/L 3compartmentss NA 50% Human Human +DTXSID0052463 Css NA 8.887 mg/L 3compartmentss NA 95% Human Human +DTXSID0052463 Css NA 0.5959 mg/L PBTK NA 50% Human Human +DTXSID0052463 Css NA 5.283 mg/L PBTK NA 95% Human Human +DTXSID0052463 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052463 Fup 0.0312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052463 Vd NA 0.9997 L/kg 1compartment NA NA Rat Human DTXSID0052463 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052463 TK.Half.Life NA 4.018 hours 1compartment NA NA Rat Human -DTXSID0052463 Css NA 0.5121 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052463 Css NA 2.834 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052463 Css NA 0.3122 mg/L PBTK NA 50% Rat Human -DTXSID0052463 Css NA 1.639 mg/L PBTK NA 95% Rat Human +DTXSID0052463 TK.Half.Life NA 3.497 hours 1compartment NA NA Rat Human +DTXSID0052463 Css NA 0.1275 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052463 Css NA 0.8835 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052463 Css NA 0.07737 mg/L PBTK NA 50% Rat Human +DTXSID0052463 Css NA 0.5156 mg/L PBTK NA 95% Rat Human DTXSID0052542 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0052542 Fup NA 0.8872 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052542 Vd NA 1.149 L/kg 1compartment NA NA Human Human +DTXSID0052542 Vd NA 1.221 L/kg 1compartment NA NA Human Human DTXSID0052542 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052542 TK.Half.Life NA 8.706 hours 1compartment NA NA Human Human -DTXSID0052542 Css NA 0.8678 mg/L 3compartmentss NA 50% Human Human -DTXSID0052542 Css NA 5.179 mg/L 3compartmentss NA 95% Human Human -DTXSID0052542 Css NA 0.779 mg/L PBTK NA 50% Human Human -DTXSID0052542 Css NA 3.465 mg/L PBTK NA 95% Human Human +DTXSID0052542 TK.Half.Life NA 9.372 hours 1compartment NA NA Human Human +DTXSID0052542 Css NA 0.7332 mg/L 3compartmentss NA 50% Human Human +DTXSID0052542 Css NA 4.382 mg/L 3compartmentss NA 95% Human Human +DTXSID0052542 Css NA 0.669 mg/L PBTK NA 50% Human Human +DTXSID0052542 Css NA 2.982 mg/L PBTK NA 95% Human Human DTXSID0052542 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0052542 Fup NA 0.8872 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052542 Vd NA 1.101 L/kg 1compartment NA NA Rat Human +DTXSID0052542 Vd NA 1.155 L/kg 1compartment NA NA Rat Human DTXSID0052542 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052542 TK.Half.Life NA 2.762 hours 1compartment NA NA Rat Human -DTXSID0052542 Css NA 0.2213 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052542 Css NA 1.322 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052542 Css NA 0.1945 mg/L PBTK NA 50% Rat Human -DTXSID0052542 Css NA 0.8202 mg/L PBTK NA 95% Rat Human -DTXSID0052594 Clint NA 7.437 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052594 Fup NA 0.6384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052594 Vd NA 0.9504 L/kg 1compartment NA NA Human Human +DTXSID0052542 TK.Half.Life NA 2.906 hours 1compartment NA NA Rat Human +DTXSID0052542 Css NA 0.0137 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052542 Css NA 0.1041 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052542 Css NA 0.0119 mg/L PBTK NA 50% Rat Human +DTXSID0052542 Css NA 0.07224 mg/L PBTK NA 95% Rat Human +DTXSID0052594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052594 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052594 Vd NA 0.5254 L/kg 1compartment NA NA Human Human DTXSID0052594 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052594 TK.Half.Life NA 1.238 hours 1compartment NA NA Human Human -DTXSID0052594 Css NA 0.09261 mg/L 3compartmentss NA 50% Human Human -DTXSID0052594 Css NA 0.8758 mg/L 3compartmentss NA 95% Human Human -DTXSID0052594 Css NA 0.07729 mg/L PBTK NA 50% Human Human -DTXSID0052594 Css NA 0.6108 mg/L PBTK NA 95% Human Human -DTXSID0052594 Clint NA 7.437 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052594 Fup NA 0.6384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052594 Vd NA 0.9067 L/kg 1compartment NA NA Rat Human +DTXSID0052594 TK.Half.Life NA 0.8133 hours 1compartment NA NA Human Human +DTXSID0052594 Css NA 0.09566 mg/L 3compartmentss NA 50% Human Human +DTXSID0052594 Css NA 0.6702 mg/L 3compartmentss NA 95% Human Human +DTXSID0052594 Css NA 0.06512 mg/L PBTK NA 50% Human Human +DTXSID0052594 Css NA 0.4334 mg/L PBTK NA 95% Human Human +DTXSID0052594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052594 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052594 Vd NA 0.4976 L/kg 1compartment NA NA Rat Human DTXSID0052594 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052594 TK.Half.Life NA 0.6256 hours 1compartment NA NA Rat Human -DTXSID0052594 Css NA 0.04472 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052594 Css NA 0.3519 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052594 Css NA 0.03641 mg/L PBTK NA 50% Rat Human -DTXSID0052594 Css NA 0.2202 mg/L PBTK NA 95% Rat Human -DTXSID0052596 Clint NA 18.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052596 Fup NA 0.6278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052596 Vd NA 1.6 L/kg 1compartment NA NA Human Human +DTXSID0052594 TK.Half.Life NA 0.4201 hours 1compartment NA NA Rat Human +DTXSID0052594 Css NA 0.01218 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052594 Css NA 0.06486 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052594 Css NA 0.008158 mg/L PBTK NA 50% Rat Human +DTXSID0052594 Css NA 0.04152 mg/L PBTK NA 95% Rat Human +DTXSID0052596 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052596 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052596 Vd NA 1.026 L/kg 1compartment NA NA Human Human DTXSID0052596 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052596 TK.Half.Life NA 1.504 hours 1compartment NA NA Human Human -DTXSID0052596 Css NA 0.04162 mg/L 3compartmentss NA 50% Human Human -DTXSID0052596 Css NA 0.4458 mg/L 3compartmentss NA 95% Human Human -DTXSID0052596 Css NA 0.03614 mg/L PBTK NA 50% Human Human -DTXSID0052596 Css NA 0.3128 mg/L PBTK NA 95% Human Human -DTXSID0052596 Clint NA 18.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052596 Fup NA 0.6278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052596 Vd NA 1.369 L/kg 1compartment NA NA Rat Human +DTXSID0052596 TK.Half.Life NA 1.413 hours 1compartment NA NA Human Human +DTXSID0052596 Css NA 0.0764 mg/L 3compartmentss NA 50% Human Human +DTXSID0052596 Css NA 0.5492 mg/L 3compartmentss NA 95% Human Human +DTXSID0052596 Css NA 0.05606 mg/L PBTK NA 50% Human Human +DTXSID0052596 Css NA 0.371 mg/L PBTK NA 95% Human Human +DTXSID0052596 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052596 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052596 Vd NA 0.8701 L/kg 1compartment NA NA Rat Human DTXSID0052596 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052596 TK.Half.Life NA 0.6134 hours 1compartment NA NA Rat Human -DTXSID0052596 Css NA 0.02134 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052596 Css NA 0.1821 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052596 Css NA 0.01832 mg/L PBTK NA 50% Rat Human -DTXSID0052596 Css NA 0.1222 mg/L PBTK NA 95% Rat Human -DTXSID0052598 Clint NA 0.2566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052598 Fup NA 0.8035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052598 Vd NA 0.8113 L/kg 1compartment NA NA Human Human +DTXSID0052596 TK.Half.Life NA 0.6233 hours 1compartment NA NA Rat Human +DTXSID0052596 Css NA 0.00943 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052596 Css NA 0.05587 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052596 Css NA 0.006902 mg/L PBTK NA 50% Rat Human +DTXSID0052596 Css NA 0.03721 mg/L PBTK NA 95% Rat Human +DTXSID0052598 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052598 Fup 0.733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052598 Vd NA 0.8048 L/kg 1compartment NA NA Human Human DTXSID0052598 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052598 TK.Half.Life NA 4.649 hours 1compartment NA NA Human Human -DTXSID0052598 Css NA 0.6686 mg/L 3compartmentss NA 50% Human Human -DTXSID0052598 Css NA 4.137 mg/L 3compartmentss NA 95% Human Human -DTXSID0052598 Css NA 0.562 mg/L PBTK NA 50% Human Human -DTXSID0052598 Css NA 2.683 mg/L PBTK NA 95% Human Human -DTXSID0052598 Clint NA 0.2566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052598 Fup NA 0.8035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052598 Vd NA 0.8249 L/kg 1compartment NA NA Rat Human +DTXSID0052598 TK.Half.Life NA 7.149 hours 1compartment NA NA Human Human +DTXSID0052598 Css NA 1.001 mg/L 3compartmentss NA 50% Human Human +DTXSID0052598 Css NA 6.579 mg/L 3compartmentss NA 95% Human Human +DTXSID0052598 Css NA 0.8371 mg/L PBTK NA 50% Human Human +DTXSID0052598 Css NA 4.226 mg/L PBTK NA 95% Human Human +DTXSID0052598 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052598 Fup 0.733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052598 Vd NA 0.8106 L/kg 1compartment NA NA Rat Human DTXSID0052598 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052598 TK.Half.Life NA 1.885 hours 1compartment NA NA Rat Human -DTXSID0052598 Css NA 0.2052 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052598 Css NA 1.263 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052598 Css NA 0.167 mg/L PBTK NA 50% Rat Human -DTXSID0052598 Css NA 0.7635 mg/L PBTK NA 95% Rat Human -DTXSID0052833 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052833 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052833 Vd NA 0.7451 L/kg 1compartment NA NA Human Human -DTXSID0052833 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052833 TK.Half.Life NA 4.824 hours 1compartment NA NA Human Human -DTXSID0052833 Css NA 0.832 mg/L 3compartmentss NA 50% Human Human -DTXSID0052833 Css NA 5.557 mg/L 3compartmentss NA 95% Human Human -DTXSID0052833 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID0052833 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID0052833 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052833 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052833 Vd NA 0.7877 L/kg 1compartment NA NA Rat Human -DTXSID0052833 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052833 TK.Half.Life NA 1.737 hours 1compartment NA NA Rat Human -DTXSID0052833 Css NA 0.2087 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052833 Css NA 1.331 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052833 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID0052833 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID0052837 Clint NA 15.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052837 Fup NA 0.1345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052837 Vd NA 0.3626 L/kg 1compartment NA NA Human Human +DTXSID0052598 TK.Half.Life NA 2.442 hours 1compartment NA NA Rat Human +DTXSID0052598 Css NA 0.05984 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052598 Css NA 0.3738 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052598 Css NA 0.04998 mg/L PBTK NA 50% Rat Human +DTXSID0052598 Css NA 0.2311 mg/L PBTK NA 95% Rat Human +DTXSID0052621 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052621 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052621 Vd NA 1.408 L/kg 1compartment NA NA Human Human +DTXSID0052621 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0052621 TK.Half.Life NA 3.35 hours 1compartment NA NA Human Human +DTXSID0052621 Css NA 0.2312 mg/L 3compartmentss NA 50% Human Human +DTXSID0052621 Css NA 1.86 mg/L 3compartmentss NA 95% Human Human +DTXSID0052621 Css NA 0.1559 mg/L PBTK NA 50% Human Human +DTXSID0052621 Css NA 1.194 mg/L PBTK NA 95% Human Human +DTXSID0052621 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052621 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052621 Vd NA 1.092 L/kg 1compartment NA NA Rat Human +DTXSID0052621 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0052621 TK.Half.Life NA 1.333 hours 1compartment NA NA Rat Human +DTXSID0052621 Css NA 0.02972 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052621 Css NA 0.1781 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052621 Css NA 0.0196 mg/L PBTK NA 50% Rat Human +DTXSID0052621 Css NA 0.1108 mg/L PBTK NA 95% Rat Human +DTXSID0052629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052629 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052629 Vd NA 1.273 L/kg 1compartment NA NA Human Human +DTXSID0052629 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0052629 TK.Half.Life NA 1.779 hours 1compartment NA NA Human Human +DTXSID0052629 Css NA 0.07726 mg/L 3compartmentss NA 50% Human Human +DTXSID0052629 Css NA 0.5667 mg/L 3compartmentss NA 95% Human Human +DTXSID0052629 Css NA 0.05748 mg/L PBTK NA 50% Human Human +DTXSID0052629 Css NA 0.3839 mg/L PBTK NA 95% Human Human +DTXSID0052629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052629 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052629 Vd NA 1.046 L/kg 1compartment NA NA Rat Human +DTXSID0052629 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0052629 TK.Half.Life NA 0.7406 hours 1compartment NA NA Rat Human +DTXSID0052629 Css NA 0.009812 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052629 Css NA 0.0543 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052629 Css NA 0.007298 mg/L PBTK NA 50% Rat Human +DTXSID0052629 Css NA 0.03712 mg/L PBTK NA 95% Rat Human +DTXSID0052673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052673 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052673 Vd NA 1.236 L/kg 1compartment NA NA Human Human +DTXSID0052673 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0052673 TK.Half.Life NA 2.259 hours 1compartment NA NA Human Human +DTXSID0052673 Css NA 0.1318 mg/L 3compartmentss NA 50% Human Human +DTXSID0052673 Css NA 0.9406 mg/L 3compartmentss NA 95% Human Human +DTXSID0052673 Css NA 0.09166 mg/L PBTK NA 50% Human Human +DTXSID0052673 Css NA 0.6321 mg/L PBTK NA 95% Human Human +DTXSID0052673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052673 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052673 Vd NA 0.9873 L/kg 1compartment NA NA Rat Human +DTXSID0052673 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0052673 TK.Half.Life NA 0.9391 hours 1compartment NA NA Rat Human +DTXSID0052673 Css NA 0.01682 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052673 Css NA 0.08968 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052673 Css NA 0.01164 mg/L PBTK NA 50% Rat Human +DTXSID0052673 Css NA 0.05955 mg/L PBTK NA 95% Rat Human +DTXSID0052831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052831 Fup 0.0125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052831 Vd NA 3.023 L/kg 1compartment NA NA Human Human +DTXSID0052831 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID0052831 TK.Half.Life NA 72.73 hours 1compartment NA NA Human Human +DTXSID0052831 Css NA 2.986 mg/L 3compartmentss NA 50% Human Human +DTXSID0052831 Css NA 19.15 mg/L 3compartmentss NA 95% Human Human +DTXSID0052831 Css NA 2.043 mg/L PBTK NA 50% Human Human +DTXSID0052831 Css NA 12.67 mg/L PBTK NA 95% Human Human +DTXSID0052831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052831 Fup 0.0125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052831 Vd NA 2.264 L/kg 1compartment NA NA Rat Human +DTXSID0052831 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID0052831 TK.Half.Life NA 11.22 hours 1compartment NA NA Rat Human +DTXSID0052831 Css NA 0.3864 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052831 Css NA 2.278 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052831 Css NA 0.2622 mg/L PBTK NA 50% Rat Human +DTXSID0052831 Css NA 1.492 mg/L PBTK NA 95% Rat Human +DTXSID0052837 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052837 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052837 Vd NA 0.3841 L/kg 1compartment NA NA Human Human DTXSID0052837 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052837 TK.Half.Life NA 0.9506 hours 1compartment NA NA Human Human -DTXSID0052837 Css NA 0.2891 mg/L 3compartmentss NA 50% Human Human -DTXSID0052837 Css NA 2.239 mg/L 3compartmentss NA 95% Human Human -DTXSID0052837 Css NA 0.1839 mg/L PBTK NA 50% Human Human -DTXSID0052837 Css NA 1.333 mg/L PBTK NA 95% Human Human -DTXSID0052837 Clint NA 15.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052837 Fup NA 0.1345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052837 Vd NA 0.3417 L/kg 1compartment NA NA Rat Human +DTXSID0052837 TK.Half.Life NA 1.027 hours 1compartment NA NA Human Human +DTXSID0052837 Css NA 0.1244 mg/L 3compartmentss NA 50% Human Human +DTXSID0052837 Css NA 0.9183 mg/L 3compartmentss NA 95% Human Human +DTXSID0052837 Css NA 0.0842 mg/L PBTK NA 50% Human Human +DTXSID0052837 Css NA 0.5807 mg/L PBTK NA 95% Human Human +DTXSID0052837 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052837 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052837 Vd NA 0.3805 L/kg 1compartment NA NA Rat Human DTXSID0052837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052837 TK.Half.Life NA 0.5279 hours 1compartment NA NA Rat Human -DTXSID0052837 Css NA 0.1611 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052837 Css NA 0.9513 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052837 Css NA 0.09597 mg/L PBTK NA 50% Rat Human -DTXSID0052837 Css NA 0.5364 mg/L PBTK NA 95% Rat Human -DTXSID0052839 Clint NA 1.136 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052839 Fup NA 0.2423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0052839 Vd NA 0.9857 L/kg 1compartment NA NA Human Human -DTXSID0052839 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0052839 TK.Half.Life NA 10.03 hours 1compartment NA NA Human Human -DTXSID0052839 Css NA 1.152 mg/L 3compartmentss NA 50% Human Human -DTXSID0052839 Css NA 4.937 mg/L 3compartmentss NA 95% Human Human -DTXSID0052839 Css NA 0.8254 mg/L PBTK NA 50% Human Human -DTXSID0052839 Css NA 3.183 mg/L PBTK NA 95% Human Human -DTXSID0052839 Clint NA 1.136 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052839 Fup NA 0.2423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0052839 Vd NA 0.8291 L/kg 1compartment NA NA Rat Human +DTXSID0052837 TK.Half.Life NA 0.5815 hours 1compartment NA NA Rat Human +DTXSID0052837 Css NA 0.001226 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052837 Css NA 0.007348 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052837 Css NA 0.0007898 mg/L PBTK NA 50% Rat Human +DTXSID0052837 Css NA 0.004353 mg/L PBTK NA 95% Rat Human +DTXSID0052839 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052839 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0052839 Vd NA 1.173 L/kg 1compartment NA NA Human Human +DTXSID0052839 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0052839 TK.Half.Life NA 17.8 hours 1compartment NA NA Human Human +DTXSID0052839 Css NA 1.519 mg/L 3compartmentss NA 50% Human Human +DTXSID0052839 Css NA 7.209 mg/L 3compartmentss NA 95% Human Human +DTXSID0052839 Css NA 1.24 mg/L PBTK NA 50% Human Human +DTXSID0052839 Css NA 4.763 mg/L PBTK NA 95% Human Human +DTXSID0052839 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052839 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0052839 Vd NA 1.027 L/kg 1compartment NA NA Rat Human DTXSID0052839 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0052839 TK.Half.Life NA 4.004 hours 1compartment NA NA Rat Human -DTXSID0052839 Css NA 0.4752 mg/L 3compartmentss NA 50% Rat Human -DTXSID0052839 Css NA 1.624 mg/L 3compartmentss NA 95% Rat Human -DTXSID0052839 Css NA 0.327 mg/L PBTK NA 50% Rat Human -DTXSID0052839 Css NA 0.9723 mg/L PBTK NA 95% Rat Human -DTXSID0057621 Clint NA 4.218 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057621 Fup NA 0.6216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057621 Vd NA 1.056 L/kg 1compartment NA NA Human Human +DTXSID0052839 TK.Half.Life NA 4.926 hours 1compartment NA NA Rat Human +DTXSID0052839 Css NA 0.09572 mg/L 3compartmentss NA 50% Rat Human +DTXSID0052839 Css NA 0.4037 mg/L 3compartmentss NA 95% Rat Human +DTXSID0052839 Css NA 0.07785 mg/L PBTK NA 50% Rat Human +DTXSID0052839 Css NA 0.2569 mg/L PBTK NA 95% Rat Human +DTXSID0057621 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057621 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057621 Vd NA 0.6003 L/kg 1compartment NA NA Human Human DTXSID0057621 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057621 TK.Half.Life NA 1.924 hours 1compartment NA NA Human Human -DTXSID0057621 Css NA 0.155 mg/L 3compartmentss NA 50% Human Human -DTXSID0057621 Css NA 1.333 mg/L 3compartmentss NA 95% Human Human -DTXSID0057621 Css NA 0.1295 mg/L PBTK NA 50% Human Human -DTXSID0057621 Css NA 0.8854 mg/L PBTK NA 95% Human Human -DTXSID0057621 Clint NA 4.218 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057621 Fup NA 0.6216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057621 Vd NA 0.9787 L/kg 1compartment NA NA Rat Human +DTXSID0057621 TK.Half.Life NA 1.24 hours 1compartment NA NA Human Human +DTXSID0057621 Css NA 0.1628 mg/L 3compartmentss NA 50% Human Human +DTXSID0057621 Css NA 1.061 mg/L 3compartmentss NA 95% Human Human +DTXSID0057621 Css NA 0.1236 mg/L PBTK NA 50% Human Human +DTXSID0057621 Css NA 0.7076 mg/L PBTK NA 95% Human Human +DTXSID0057621 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057621 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057621 Vd NA 0.6082 L/kg 1compartment NA NA Rat Human DTXSID0057621 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057621 TK.Half.Life NA 0.9463 hours 1compartment NA NA Rat Human -DTXSID0057621 Css NA 0.07278 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057621 Css NA 0.5385 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057621 Css NA 0.05932 mg/L PBTK NA 50% Rat Human -DTXSID0057621 Css NA 0.3306 mg/L PBTK NA 95% Rat Human -DTXSID0057625 Clint NA 552.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057625 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057625 Vd NA 2.87 L/kg 1compartment NA NA Human Human -DTXSID0057625 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057625 TK.Half.Life NA 4.37 hours 1compartment NA NA Human Human -DTXSID0057625 Css NA 0.0961 mg/L 3compartmentss NA 50% Human Human -DTXSID0057625 Css NA 0.6524 mg/L 3compartmentss NA 95% Human Human -DTXSID0057625 Css NA 0.06512 mg/L PBTK NA 50% Human Human -DTXSID0057625 Css NA 0.4227 mg/L PBTK NA 95% Human Human -DTXSID0057625 Clint NA 552.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057625 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057625 Vd NA 2.147 L/kg 1compartment NA NA Rat Human -DTXSID0057625 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057625 TK.Half.Life NA 1.133 hours 1compartment NA NA Rat Human -DTXSID0057625 Css NA 0.0543 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057625 Css NA 0.3031 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057625 Css NA 0.03509 mg/L PBTK NA 50% Rat Human -DTXSID0057625 Css NA 0.1907 mg/L PBTK NA 95% Rat Human -DTXSID0057627 Clint NA 77.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057627 Fup NA 0.0451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057627 Vd NA 2.023 L/kg 1compartment NA NA Human Human +DTXSID0057621 TK.Half.Life NA 0.707 hours 1compartment NA NA Rat Human +DTXSID0057621 Css NA 0.01901 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057621 Css NA 0.09583 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057621 Css NA 0.01432 mg/L PBTK NA 50% Rat Human +DTXSID0057621 Css NA 0.06193 mg/L PBTK NA 95% Rat Human +DTXSID0057625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057625 Fup 0.0209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057625 Vd NA 3.113 L/kg 1compartment NA NA Human Human +DTXSID0057625 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID0057625 TK.Half.Life NA 88.4 hours 1compartment NA NA Human Human +DTXSID0057625 Css NA 3.373 mg/L 3compartmentss NA 50% Human Human +DTXSID0057625 Css NA 20.95 mg/L 3compartmentss NA 95% Human Human +DTXSID0057625 Css NA 2.332 mg/L PBTK NA 50% Human Human +DTXSID0057625 Css NA 14.21 mg/L PBTK NA 95% Human Human +DTXSID0057625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057625 Fup 0.0209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057625 Vd NA 2.333 L/kg 1compartment NA NA Rat Human +DTXSID0057625 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID0057625 TK.Half.Life NA 12 hours 1compartment NA NA Rat Human +DTXSID0057625 Css NA 0.4364 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057625 Css NA 2.276 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057625 Css NA 0.2994 mg/L PBTK NA 50% Rat Human +DTXSID0057625 Css NA 1.533 mg/L PBTK NA 95% Rat Human +DTXSID0057627 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057627 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057627 Vd NA 1.62 L/kg 1compartment NA NA Human Human DTXSID0057627 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057627 TK.Half.Life NA 2.986 hours 1compartment NA NA Human Human -DTXSID0057627 Css NA 0.1108 mg/L 3compartmentss NA 50% Human Human -DTXSID0057627 Css NA 0.8986 mg/L 3compartmentss NA 95% Human Human -DTXSID0057627 Css NA 0.0794 mg/L PBTK NA 50% Human Human -DTXSID0057627 Css NA 0.5956 mg/L PBTK NA 95% Human Human -DTXSID0057627 Clint NA 77.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057627 Fup NA 0.0451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057627 Vd NA 1.804 L/kg 1compartment NA NA Rat Human +DTXSID0057627 TK.Half.Life NA 2.869 hours 1compartment NA NA Human Human +DTXSID0057627 Css NA 0.1549 mg/L 3compartmentss NA 50% Human Human +DTXSID0057627 Css NA 1.848 mg/L 3compartmentss NA 95% Human Human +DTXSID0057627 Css NA 0.1169 mg/L PBTK NA 50% Human Human +DTXSID0057627 Css NA 1.198 mg/L PBTK NA 95% Human Human +DTXSID0057627 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057627 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057627 Vd NA 1.544 L/kg 1compartment NA NA Rat Human DTXSID0057627 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057627 TK.Half.Life NA 1.368 hours 1compartment NA NA Rat Human -DTXSID0057627 Css NA 0.06282 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057627 Css NA 0.4239 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057627 Css NA 0.04286 mg/L PBTK NA 50% Rat Human -DTXSID0057627 Css NA 0.2688 mg/L PBTK NA 95% Rat Human -DTXSID0057629 Clint NA 5.883 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057629 Fup NA 0.6846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057629 Vd NA 0.6404 L/kg 1compartment NA NA Human Human +DTXSID0057627 TK.Half.Life NA 1.581 hours 1compartment NA NA Rat Human +DTXSID0057627 Css NA 0.02068 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057627 Css NA 0.2023 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057627 Css NA 0.01507 mg/L PBTK NA 50% Rat Human +DTXSID0057627 Css NA 0.1292 mg/L PBTK NA 95% Rat Human +DTXSID0057629 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057629 Fup 0.644 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057629 Vd NA 0.3845 L/kg 1compartment NA NA Human Human DTXSID0057629 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057629 TK.Half.Life NA 0.9038 hours 1compartment NA NA Human Human -DTXSID0057629 Css NA 0.1118 mg/L 3compartmentss NA 50% Human Human -DTXSID0057629 Css NA 1.016 mg/L 3compartmentss NA 95% Human Human -DTXSID0057629 Css NA 0.08674 mg/L PBTK NA 50% Human Human -DTXSID0057629 Css NA 0.6688 mg/L PBTK NA 95% Human Human -DTXSID0057629 Clint NA 5.883 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057629 Fup NA 0.6846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057629 Vd NA 0.6688 L/kg 1compartment NA NA Rat Human +DTXSID0057629 TK.Half.Life NA 3.862 hours 1compartment NA NA Human Human +DTXSID0057629 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human +DTXSID0057629 Css NA 6.865 mg/L 3compartmentss NA 95% Human Human +DTXSID0057629 Css NA 0.7863 mg/L PBTK NA 50% Human Human +DTXSID0057629 Css NA 4.203 mg/L PBTK NA 95% Human Human +DTXSID0057629 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057629 Fup 0.644 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057629 Vd NA 0.4045 L/kg 1compartment NA NA Rat Human DTXSID0057629 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057629 TK.Half.Life NA 0.5037 hours 1compartment NA NA Rat Human -DTXSID0057629 Css NA 0.05382 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057629 Css NA 0.4233 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057629 Css NA 0.04115 mg/L PBTK NA 50% Rat Human -DTXSID0057629 Css NA 0.2508 mg/L PBTK NA 95% Rat Human -DTXSID0057671 Clint NA 58.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057671 Fup NA 0.0403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057671 Vd NA 1.589 L/kg 1compartment NA NA Human Human +DTXSID0057629 TK.Half.Life NA 1.385 hours 1compartment NA NA Rat Human +DTXSID0057629 Css NA 0.0216 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057629 Css NA 0.1683 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057629 Css NA 0.01464 mg/L PBTK NA 50% Rat Human +DTXSID0057629 Css NA 0.1003 mg/L PBTK NA 95% Rat Human +DTXSID0057671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057671 Fup 0.0798 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057671 Vd NA 1.958 L/kg 1compartment NA NA Human Human DTXSID0057671 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057671 TK.Half.Life NA 4.209 hours 1compartment NA NA Human Human -DTXSID0057671 Css NA 0.3052 mg/L 3compartmentss NA 50% Human Human -DTXSID0057671 Css NA 2.722 mg/L 3compartmentss NA 95% Human Human -DTXSID0057671 Css NA 0.1943 mg/L PBTK NA 50% Human Human -DTXSID0057671 Css NA 1.685 mg/L PBTK NA 95% Human Human -DTXSID0057671 Clint NA 58.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057671 Fup NA 0.0403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057671 Vd NA 1.189 L/kg 1compartment NA NA Rat Human +DTXSID0057671 TK.Half.Life NA 7.486 hours 1compartment NA NA Human Human +DTXSID0057671 Css NA 0.4457 mg/L 3compartmentss NA 50% Human Human +DTXSID0057671 Css NA 3.186 mg/L 3compartmentss NA 95% Human Human +DTXSID0057671 Css NA 0.297 mg/L PBTK NA 50% Human Human +DTXSID0057671 Css NA 2.019 mg/L PBTK NA 95% Human Human +DTXSID0057671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057671 Fup 0.0798 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057671 Vd NA 1.477 L/kg 1compartment NA NA Rat Human DTXSID0057671 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057671 TK.Half.Life NA 1.551 hours 1compartment NA NA Rat Human -DTXSID0057671 Css NA 0.1745 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057671 Css NA 1.262 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057671 Css NA 0.1046 mg/L PBTK NA 50% Rat Human -DTXSID0057671 Css NA 0.7269 mg/L PBTK NA 95% Rat Human -DTXSID0057673 Clint NA 2.959 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057673 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057673 Vd NA 0.2395 L/kg 1compartment NA NA Human Human -DTXSID0057673 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0057673 TK.Half.Life NA 16.32 hours 1compartment NA NA Human Human -DTXSID0057673 Css NA 12.57 mg/L 3compartmentss NA 50% Human Human -DTXSID0057673 Css NA 94.82 mg/L 3compartmentss NA 95% Human Human -DTXSID0057673 Css NA 7.422 mg/L PBTK NA 50% Human Human -DTXSID0057673 Css NA 55.57 mg/L PBTK NA 95% Human Human -DTXSID0057673 Clint NA 2.959 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057673 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057673 Vd NA 0.2137 L/kg 1compartment NA NA Rat Human +DTXSID0057671 TK.Half.Life NA 2.509 hours 1compartment NA NA Rat Human +DTXSID0057671 Css NA 0.05774 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057671 Css NA 0.3193 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057671 Css NA 0.03794 mg/L PBTK NA 50% Rat Human +DTXSID0057671 Css NA 0.1989 mg/L PBTK NA 95% Rat Human +DTXSID0057673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057673 Fup 0.0642 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057673 Vd NA 0.4259 L/kg 1compartment NA NA Human Human +DTXSID0057673 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0057673 TK.Half.Life NA 1.508 hours 1compartment NA NA Human Human +DTXSID0057673 Css NA 0.4576 mg/L 3compartmentss NA 50% Human Human +DTXSID0057673 Css NA 3.54 mg/L 3compartmentss NA 95% Human Human +DTXSID0057673 Css NA 0.2812 mg/L PBTK NA 50% Human Human +DTXSID0057673 Css NA 2.133 mg/L PBTK NA 95% Human Human +DTXSID0057673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057673 Fup 0.0642 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057673 Vd NA 0.3594 L/kg 1compartment NA NA Rat Human DTXSID0057673 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057673 TK.Half.Life NA 8.647 hours 1compartment NA NA Rat Human -DTXSID0057673 Css NA 6.306 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057673 Css NA 36.99 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057673 Css NA 3.451 mg/L PBTK NA 50% Rat Human -DTXSID0057673 Css NA 20.03 mg/L PBTK NA 95% Rat Human -DTXSID0057677 Clint NA 32.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057677 Fup NA 0.0271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057677 Vd NA 3.045 L/kg 1compartment NA NA Human Human -DTXSID0057677 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID0057677 TK.Half.Life NA 42.21 hours 1compartment NA NA Human Human -DTXSID0057677 Css NA 1.71 mg/L 3compartmentss NA 50% Human Human -DTXSID0057677 Css NA 11.34 mg/L 3compartmentss NA 95% Human Human -DTXSID0057677 Css NA 1.174 mg/L PBTK NA 50% Human Human -DTXSID0057677 Css NA 7.486 mg/L PBTK NA 95% Human Human -DTXSID0057677 Clint NA 32.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057677 Fup NA 0.0271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057677 Vd NA 2.28 L/kg 1compartment NA NA Rat Human -DTXSID0057677 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID0057677 TK.Half.Life NA 6.527 hours 1compartment NA NA Rat Human -DTXSID0057677 Css NA 0.947 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057677 Css NA 5.144 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057677 Css NA 0.6235 mg/L PBTK NA 50% Rat Human -DTXSID0057677 Css NA 3.35 mg/L PBTK NA 95% Rat Human -DTXSID0057679 Clint NA 18.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057679 Fup NA 0.6803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057679 Vd NA 2.845 L/kg 1compartment NA NA Human Human +DTXSID0057673 TK.Half.Life NA 0.7753 hours 1compartment NA NA Rat Human +DTXSID0057673 Css NA 0.0606 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057673 Css NA 0.3643 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057673 Css NA 0.03596 mg/L PBTK NA 50% Rat Human +DTXSID0057673 Css NA 0.2115 mg/L PBTK NA 95% Rat Human +DTXSID0057677 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057677 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057677 Vd NA 3.055 L/kg 1compartment NA NA Human Human +DTXSID0057677 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID0057677 TK.Half.Life NA 78.81 hours 1compartment NA NA Human Human +DTXSID0057677 Css NA 3.147 mg/L 3compartmentss NA 50% Human Human +DTXSID0057677 Css NA 19.92 mg/L 3compartmentss NA 95% Human Human +DTXSID0057677 Css NA 2.17 mg/L PBTK NA 50% Human Human +DTXSID0057677 Css NA 13.45 mg/L PBTK NA 95% Human Human +DTXSID0057677 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057677 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057677 Vd NA 2.287 L/kg 1compartment NA NA Rat Human +DTXSID0057677 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID0057677 TK.Half.Life NA 11.6 hours 1compartment NA NA Rat Human +DTXSID0057677 Css NA 0.4095 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057677 Css NA 2.327 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057677 Css NA 0.2784 mg/L PBTK NA 50% Rat Human +DTXSID0057677 Css NA 1.539 mg/L PBTK NA 95% Rat Human +DTXSID0057679 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057679 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057679 Vd NA 0.9109 L/kg 1compartment NA NA Human Human DTXSID0057679 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057679 TK.Half.Life NA 2.016 hours 1compartment NA NA Human Human -DTXSID0057679 Css NA 0.02679 mg/L 3compartmentss NA 50% Human Human -DTXSID0057679 Css NA 0.318 mg/L 3compartmentss NA 95% Human Human -DTXSID0057679 Css NA 0.0298 mg/L PBTK NA 50% Human Human -DTXSID0057679 Css NA 0.2575 mg/L PBTK NA 95% Human Human -DTXSID0057679 Clint NA 18.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057679 Fup NA 0.6803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057679 Vd NA 2.885 L/kg 1compartment NA NA Rat Human +DTXSID0057679 TK.Half.Life NA 1.502 hours 1compartment NA NA Human Human +DTXSID0057679 Css NA 0.122 mg/L 3compartmentss NA 50% Human Human +DTXSID0057679 Css NA 0.9897 mg/L 3compartmentss NA 95% Human Human +DTXSID0057679 Css NA 0.09748 mg/L PBTK NA 50% Human Human +DTXSID0057679 Css NA 0.6692 mg/L PBTK NA 95% Human Human +DTXSID0057679 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057679 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057679 Vd NA 0.8414 L/kg 1compartment NA NA Rat Human DTXSID0057679 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057679 TK.Half.Life NA 1.057 hours 1compartment NA NA Rat Human -DTXSID0057679 Css NA 0.01321 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057679 Css NA 0.1436 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057679 Css NA 0.01494 mg/L PBTK NA 50% Rat Human -DTXSID0057679 Css NA 0.1059 mg/L PBTK NA 95% Rat Human -DTXSID0057700 Clint NA 9.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057700 Fup NA 0.3677 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057700 Vd NA 1.571 L/kg 1compartment NA NA Human Human +DTXSID0057679 TK.Half.Life NA 0.7448 hours 1compartment NA NA Rat Human +DTXSID0057679 Css NA 0.01408 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057679 Css NA 0.09058 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057679 Css NA 0.01128 mg/L PBTK NA 50% Rat Human +DTXSID0057679 Css NA 0.05851 mg/L PBTK NA 95% Rat Human +DTXSID0057700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057700 Fup 0.218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057700 Vd NA 1.185 L/kg 1compartment NA NA Human Human DTXSID0057700 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057700 TK.Half.Life NA 3.031 hours 1compartment NA NA Human Human -DTXSID0057700 Css NA 0.1495 mg/L 3compartmentss NA 50% Human Human -DTXSID0057700 Css NA 0.928 mg/L 3compartmentss NA 95% Human Human -DTXSID0057700 Css NA 0.1168 mg/L PBTK NA 50% Human Human -DTXSID0057700 Css NA 0.6596 mg/L PBTK NA 95% Human Human -DTXSID0057700 Clint NA 9.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057700 Fup NA 0.3677 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057700 Vd NA 1.283 L/kg 1compartment NA NA Rat Human +DTXSID0057700 TK.Half.Life NA 1.907 hours 1compartment NA NA Human Human +DTXSID0057700 Css NA 0.1035 mg/L 3compartmentss NA 50% Human Human +DTXSID0057700 Css NA 0.7058 mg/L 3compartmentss NA 95% Human Human +DTXSID0057700 Css NA 0.07398 mg/L PBTK NA 50% Human Human +DTXSID0057700 Css NA 0.4785 mg/L PBTK NA 95% Human Human +DTXSID0057700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057700 Fup 0.218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057700 Vd NA 0.964 L/kg 1compartment NA NA Rat Human DTXSID0057700 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057700 TK.Half.Life NA 1.223 hours 1compartment NA NA Rat Human -DTXSID0057700 Css NA 0.07651 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057700 Css NA 0.3793 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057700 Css NA 0.05831 mg/L PBTK NA 50% Rat Human -DTXSID0057700 Css NA 0.2539 mg/L PBTK NA 95% Rat Human -DTXSID0057702 Clint NA 30.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057702 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057702 Vd NA 0.2366 L/kg 1compartment NA NA Human Human +DTXSID0057700 TK.Half.Life NA 0.805 hours 1compartment NA NA Rat Human +DTXSID0057700 Css NA 0.01294 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057700 Css NA 0.06971 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057700 Css NA 0.009173 mg/L PBTK NA 50% Rat Human +DTXSID0057700 Css NA 0.0459 mg/L PBTK NA 95% Rat Human +DTXSID0057702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057702 Fup 0.061 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057702 Vd NA 1.931 L/kg 1compartment NA NA Human Human DTXSID0057702 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057702 TK.Half.Life NA 1.141 hours 1compartment NA NA Human Human -DTXSID0057702 Css NA 0.7554 mg/L 3compartmentss NA 50% Human Human -DTXSID0057702 Css NA 6.861 mg/L 3compartmentss NA 95% Human Human -DTXSID0057702 Css NA 0.45 mg/L PBTK NA 50% Human Human -DTXSID0057702 Css NA 4.103 mg/L PBTK NA 95% Human Human -DTXSID0057702 Clint NA 30.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057702 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057702 Vd NA 0.2327 L/kg 1compartment NA NA Rat Human +DTXSID0057702 TK.Half.Life NA 8.805 hours 1compartment NA NA Human Human +DTXSID0057702 Css NA 0.589 mg/L 3compartmentss NA 50% Human Human +DTXSID0057702 Css NA 4.01 mg/L 3compartmentss NA 95% Human Human +DTXSID0057702 Css NA 0.387 mg/L PBTK NA 50% Human Human +DTXSID0057702 Css NA 2.547 mg/L PBTK NA 95% Human Human +DTXSID0057702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057702 Fup 0.061 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057702 Vd NA 1.457 L/kg 1compartment NA NA Rat Human DTXSID0057702 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057702 TK.Half.Life NA 0.715 hours 1compartment NA NA Rat Human -DTXSID0057702 Css NA 0.4352 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057702 Css NA 3.291 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057702 Css NA 0.2426 mg/L PBTK NA 50% Rat Human -DTXSID0057702 Css NA 1.8 mg/L PBTK NA 95% Rat Human -DTXSID0057704 Clint NA 0.329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057704 Fup NA 0.8992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057704 Vd NA 2.059 L/kg 1compartment NA NA Human Human -DTXSID0057704 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057704 TK.Half.Life NA 9.803 hours 1compartment NA NA Human Human -DTXSID0057704 Css NA 0.4605 mg/L 3compartmentss NA 50% Human Human -DTXSID0057704 Css NA 2.028 mg/L 3compartmentss NA 95% Human Human -DTXSID0057704 Css NA 0.4707 mg/L PBTK NA 50% Human Human -DTXSID0057704 Css NA 1.569 mg/L PBTK NA 95% Human Human -DTXSID0057704 Clint NA 0.329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057704 Fup NA 0.8992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057704 Vd NA 2.081 L/kg 1compartment NA NA Rat Human +DTXSID0057702 TK.Half.Life NA 2.993 hours 1compartment NA NA Rat Human +DTXSID0057702 Css NA 0.07539 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057702 Css NA 0.4341 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057702 Css NA 0.04887 mg/L PBTK NA 50% Rat Human +DTXSID0057702 Css NA 0.2672 mg/L PBTK NA 95% Rat Human +DTXSID0057704 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057704 Fup 0.891 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057704 Vd NA 1.745 L/kg 1compartment NA NA Human Human +DTXSID0057704 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0057704 TK.Half.Life NA 12.71 hours 1compartment NA NA Human Human +DTXSID0057704 Css NA 0.7737 mg/L 3compartmentss NA 50% Human Human +DTXSID0057704 Css NA 4.702 mg/L 3compartmentss NA 95% Human Human +DTXSID0057704 Css NA 0.7491 mg/L PBTK NA 50% Human Human +DTXSID0057704 Css NA 3.223 mg/L PBTK NA 95% Human Human +DTXSID0057704 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057704 Fup 0.891 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057704 Vd NA 1.769 L/kg 1compartment NA NA Rat Human DTXSID0057704 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057704 TK.Half.Life NA 4.063 hours 1compartment NA NA Rat Human -DTXSID0057704 Css NA 0.1432 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057704 Css NA 0.5872 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057704 Css NA 0.1467 mg/L PBTK NA 50% Rat Human -DTXSID0057704 Css NA 0.4153 mg/L PBTK NA 95% Rat Human -DTXSID0057706 Clint NA 1.813 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057706 Fup NA 0.0731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057706 Vd NA 0.5202 L/kg 1compartment NA NA Human Human -DTXSID0057706 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0057706 TK.Half.Life NA 11.67 hours 1compartment NA NA Human Human -DTXSID0057706 Css NA 3.649 mg/L 3compartmentss NA 50% Human Human -DTXSID0057706 Css NA 20.29 mg/L 3compartmentss NA 95% Human Human -DTXSID0057706 Css NA 2.284 mg/L PBTK NA 50% Human Human -DTXSID0057706 Css NA 11.97 mg/L PBTK NA 95% Human Human -DTXSID0057706 Clint NA 1.813 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057706 Fup NA 0.0731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057706 Vd NA 0.4308 L/kg 1compartment NA NA Rat Human +DTXSID0057704 TK.Half.Life NA 4.381 hours 1compartment NA NA Rat Human +DTXSID0057704 Css NA 0.04515 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057704 Css NA 0.2938 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057704 Css NA 0.04466 mg/L PBTK NA 50% Rat Human +DTXSID0057704 Css NA 0.1928 mg/L PBTK NA 95% Rat Human +DTXSID0057706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057706 Fup 0.0639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057706 Vd NA 0.5306 L/kg 1compartment NA NA Human Human +DTXSID0057706 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0057706 TK.Half.Life NA 1.876 hours 1compartment NA NA Human Human +DTXSID0057706 Css NA 0.4602 mg/L 3compartmentss NA 50% Human Human +DTXSID0057706 Css NA 3.62 mg/L 3compartmentss NA 95% Human Human +DTXSID0057706 Css NA 0.2858 mg/L PBTK NA 50% Human Human +DTXSID0057706 Css NA 2.15 mg/L PBTK NA 95% Human Human +DTXSID0057706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057706 Fup 0.0639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057706 Vd NA 0.4344 L/kg 1compartment NA NA Rat Human DTXSID0057706 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057706 TK.Half.Life NA 5.219 hours 1compartment NA NA Rat Human -DTXSID0057706 Css NA 1.685 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057706 Css NA 7.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057706 Css NA 0.9797 mg/L PBTK NA 50% Rat Human -DTXSID0057706 Css NA 3.913 mg/L PBTK NA 95% Rat Human -DTXSID0057708 Clint NA 12.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057708 Fup NA 0.1966 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057708 Vd NA 1.421 L/kg 1compartment NA NA Human Human +DTXSID0057706 TK.Half.Life NA 0.9285 hours 1compartment NA NA Rat Human +DTXSID0057706 Css NA 0.05975 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057706 Css NA 0.3549 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057706 Css NA 0.03584 mg/L PBTK NA 50% Rat Human +DTXSID0057706 Css NA 0.2079 mg/L PBTK NA 95% Rat Human +DTXSID0057708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057708 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057708 Vd NA 1.218 L/kg 1compartment NA NA Human Human DTXSID0057708 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057708 TK.Half.Life NA 3.56 hours 1compartment NA NA Human Human -DTXSID0057708 Css NA 0.2243 mg/L 3compartmentss NA 50% Human Human -DTXSID0057708 Css NA 1.36 mg/L 3compartmentss NA 95% Human Human -DTXSID0057708 Css NA 0.1604 mg/L PBTK NA 50% Human Human -DTXSID0057708 Css NA 0.9206 mg/L PBTK NA 95% Human Human -DTXSID0057708 Clint NA 12.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057708 Fup NA 0.1966 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057708 Vd NA 1.125 L/kg 1compartment NA NA Rat Human +DTXSID0057708 TK.Half.Life NA 2.027 hours 1compartment NA NA Human Human +DTXSID0057708 Css NA 0.1084 mg/L 3compartmentss NA 50% Human Human +DTXSID0057708 Css NA 0.7425 mg/L 3compartmentss NA 95% Human Human +DTXSID0057708 Css NA 0.07762 mg/L PBTK NA 50% Human Human +DTXSID0057708 Css NA 0.4961 mg/L PBTK NA 95% Human Human +DTXSID0057708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057708 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057708 Vd NA 0.9843 L/kg 1compartment NA NA Rat Human DTXSID0057708 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057708 TK.Half.Life NA 1.445 hours 1compartment NA NA Rat Human -DTXSID0057708 Css NA 0.1179 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057708 Css NA 0.565 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057708 Css NA 0.08073 mg/L PBTK NA 50% Rat Human -DTXSID0057708 Css NA 0.3599 mg/L PBTK NA 95% Rat Human -DTXSID0057750 Clint NA 11.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057750 Fup NA 0.0042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057750 Vd NA 0.2139 L/kg 1compartment NA NA Human Human -DTXSID0057750 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID0057750 TK.Half.Life NA 16.17 hours 1compartment NA NA Human Human -DTXSID0057750 Css NA 14.33 mg/L 3compartmentss NA 50% Human Human -DTXSID0057750 Css NA 119.9 mg/L 3compartmentss NA 95% Human Human -DTXSID0057750 Css NA 8.407 mg/L PBTK NA 50% Human Human -DTXSID0057750 Css NA 69.21 mg/L PBTK NA 95% Human Human -DTXSID0057750 Clint NA 11.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057750 Fup NA 0.0042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057750 Vd NA 0.1979 L/kg 1compartment NA NA Rat Human -DTXSID0057750 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID0057750 TK.Half.Life NA 9.933 hours 1compartment NA NA Rat Human -DTXSID0057750 Css NA 7.972 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057750 Css NA 51.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057750 Css NA 4.359 mg/L PBTK NA 50% Rat Human -DTXSID0057750 Css NA 27.61 mg/L PBTK NA 95% Rat Human +DTXSID0057708 TK.Half.Life NA 0.8484 hours 1compartment NA NA Rat Human +DTXSID0057708 Css NA 0.01377 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057708 Css NA 0.072 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057708 Css NA 0.009717 mg/L PBTK NA 50% Rat Human +DTXSID0057708 Css NA 0.04747 mg/L PBTK NA 95% Rat Human +DTXSID0057750 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057750 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057750 Vd NA 0.2897 L/kg 1compartment NA NA Human Human +DTXSID0057750 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0057750 TK.Half.Life NA 3.817 hours 1compartment NA NA Human Human +DTXSID0057750 Css NA 2.264 mg/L 3compartmentss NA 50% Human Human +DTXSID0057750 Css NA 23.52 mg/L 3compartmentss NA 95% Human Human +DTXSID0057750 Css NA 1.357 mg/L PBTK NA 50% Human Human +DTXSID0057750 Css NA 13.59 mg/L PBTK NA 95% Human Human +DTXSID0057750 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057750 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057750 Vd NA 0.262 L/kg 1compartment NA NA Rat Human +DTXSID0057750 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0057750 TK.Half.Life NA 2.288 hours 1compartment NA NA Rat Human +DTXSID0057750 Css NA 0.2972 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057750 Css NA 2.35 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057750 Css NA 0.1718 mg/L PBTK NA 50% Rat Human +DTXSID0057750 Css NA 1.326 mg/L PBTK NA 95% Rat Human +DTXSID0057752 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057752 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057752 Vd NA 1.635 L/kg 1compartment NA NA Human Human +DTXSID0057752 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0057752 TK.Half.Life NA 4.77 hours 1compartment NA NA Human Human +DTXSID0057752 Css NA 0.3172 mg/L 3compartmentss NA 50% Human Human +DTXSID0057752 Css NA 2.329 mg/L 3compartmentss NA 95% Human Human +DTXSID0057752 Css NA 0.2121 mg/L PBTK NA 50% Human Human +DTXSID0057752 Css NA 1.471 mg/L PBTK NA 95% Human Human +DTXSID0057752 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057752 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057752 Vd NA 1.248 L/kg 1compartment NA NA Rat Human +DTXSID0057752 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0057752 TK.Half.Life NA 1.784 hours 1compartment NA NA Rat Human +DTXSID0057752 Css NA 0.04084 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057752 Css NA 0.2358 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057752 Css NA 0.02663 mg/L PBTK NA 50% Rat Human +DTXSID0057752 Css NA 0.148 mg/L PBTK NA 95% Rat Human DTXSID0057754 Clint NA 0.03614 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID0057754 Fup NA 0.3201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057754 Vd NA 0.475 L/kg 1compartment NA NA Human Human +DTXSID0057754 Vd NA 0.4884 L/kg 1compartment NA NA Human Human DTXSID0057754 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057754 TK.Half.Life NA 9.032 hours 1compartment NA NA Human Human -DTXSID0057754 Css NA 2.16 mg/L 3compartmentss NA 50% Human Human -DTXSID0057754 Css NA 8.93 mg/L 3compartmentss NA 95% Human Human -DTXSID0057754 Css NA 1.538 mg/L PBTK NA 50% Human Human -DTXSID0057754 Css NA 5.528 mg/L PBTK NA 95% Human Human +DTXSID0057754 TK.Half.Life NA 9.293 hours 1compartment NA NA Human Human +DTXSID0057754 Css NA 2.116 mg/L 3compartmentss NA 50% Human Human +DTXSID0057754 Css NA 8.404 mg/L 3compartmentss NA 95% Human Human +DTXSID0057754 Css NA 1.505 mg/L PBTK NA 50% Human Human +DTXSID0057754 Css NA 5.322 mg/L PBTK NA 95% Human Human DTXSID0057754 Clint NA 0.03614 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID0057754 Fup NA 0.3201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057754 Vd NA 0.4859 L/kg 1compartment NA NA Rat Human +DTXSID0057754 Vd NA 0.4983 L/kg 1compartment NA NA Rat Human DTXSID0057754 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057754 TK.Half.Life NA 3.248 hours 1compartment NA NA Rat Human -DTXSID0057754 Css NA 0.6255 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057754 Css NA 2.115 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057754 Css NA 0.4222 mg/L PBTK NA 50% Rat Human -DTXSID0057754 Css NA 1.239 mg/L PBTK NA 95% Rat Human -DTXSID0057756 Clint NA 94.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057756 Fup NA 0.1504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057756 Vd NA 4.444 L/kg 1compartment NA NA Human Human +DTXSID0057754 TK.Half.Life NA 3.331 hours 1compartment NA NA Rat Human +DTXSID0057754 Css NA 0.1405 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057754 Css NA 0.4844 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057754 Css NA 0.09871 mg/L PBTK NA 50% Rat Human +DTXSID0057754 Css NA 0.2935 mg/L PBTK NA 95% Rat Human +DTXSID0057756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057756 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057756 Vd NA 2.592 L/kg 1compartment NA NA Human Human DTXSID0057756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057756 TK.Half.Life NA 1.697 hours 1compartment NA NA Human Human -DTXSID0057756 Css NA 0.001483 mg/L 3compartmentss NA 50% Human Human -DTXSID0057756 Css NA 0.01516 mg/L 3compartmentss NA 95% Human Human -DTXSID0057756 Css NA 0.002104 mg/L PBTK NA 50% Human Human -DTXSID0057756 Css NA 0.01574 mg/L PBTK NA 95% Human Human -DTXSID0057756 Clint NA 94.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057756 Fup NA 0.1504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057756 Vd NA 4.24 L/kg 1compartment NA NA Rat Human +DTXSID0057756 TK.Half.Life NA 2.266 hours 1compartment NA NA Human Human +DTXSID0057756 Css NA 0.03691 mg/L 3compartmentss NA 50% Human Human +DTXSID0057756 Css NA 0.4089 mg/L 3compartmentss NA 95% Human Human +DTXSID0057756 Css NA 0.03735 mg/L PBTK NA 50% Human Human +DTXSID0057756 Css NA 0.318 mg/L PBTK NA 95% Human Human +DTXSID0057756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057756 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057756 Vd NA 2.531 L/kg 1compartment NA NA Rat Human DTXSID0057756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057756 TK.Half.Life NA 0.7164 hours 1compartment NA NA Rat Human -DTXSID0057756 Css NA 0.000808 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057756 Css NA 0.007091 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057756 Css NA 0.001144 mg/L PBTK NA 50% Rat Human -DTXSID0057756 Css NA 0.006961 mg/L PBTK NA 95% Rat Human -DTXSID0057758 Clint NA 80.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057758 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057758 Vd NA 1.999 L/kg 1compartment NA NA Human Human -DTXSID0057758 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057758 TK.Half.Life NA 7.807 hours 1compartment NA NA Human Human -DTXSID0057758 Css NA 0.5025 mg/L 3compartmentss NA 50% Human Human -DTXSID0057758 Css NA 4.282 mg/L 3compartmentss NA 95% Human Human -DTXSID0057758 Css NA 0.3226 mg/L PBTK NA 50% Human Human -DTXSID0057758 Css NA 2.609 mg/L PBTK NA 95% Human Human -DTXSID0057758 Clint NA 80.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057758 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057758 Vd NA 1.486 L/kg 1compartment NA NA Rat Human -DTXSID0057758 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057758 TK.Half.Life NA 2.535 hours 1compartment NA NA Rat Human -DTXSID0057758 Css NA 0.284 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057758 Css NA 2.039 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057758 Css NA 0.1728 mg/L PBTK NA 50% Rat Human -DTXSID0057758 Css NA 1.178 mg/L PBTK NA 95% Rat Human -DTXSID0057831 Clint NA 10.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057831 Fup NA 0.0631 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057831 Vd NA 1.341 L/kg 1compartment NA NA Human Human -DTXSID0057831 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057831 TK.Half.Life NA 9.371 hours 1compartment NA NA Human Human -DTXSID0057831 Css NA 1.024 mg/L 3compartmentss NA 50% Human Human -DTXSID0057831 Css NA 7.461 mg/L 3compartmentss NA 95% Human Human -DTXSID0057831 Css NA 0.658 mg/L PBTK NA 50% Human Human -DTXSID0057831 Css NA 4.607 mg/L PBTK NA 95% Human Human -DTXSID0057831 Clint NA 10.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057831 Fup NA 0.0631 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057831 Vd NA 1.027 L/kg 1compartment NA NA Rat Human +DTXSID0057756 TK.Half.Life NA 1.192 hours 1compartment NA NA Rat Human +DTXSID0057756 Css NA 0.004724 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057756 Css NA 0.04281 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057756 Css NA 0.00487 mg/L PBTK NA 50% Rat Human +DTXSID0057756 Css NA 0.03391 mg/L PBTK NA 95% Rat Human +DTXSID0057758 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057758 Fup 0.0238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057758 Vd NA 2.957 L/kg 1compartment NA NA Human Human +DTXSID0057758 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID0057758 TK.Half.Life NA 45.63 hours 1compartment NA NA Human Human +DTXSID0057758 Css NA 1.96 mg/L 3compartmentss NA 50% Human Human +DTXSID0057758 Css NA 12.75 mg/L 3compartmentss NA 95% Human Human +DTXSID0057758 Css NA 1.342 mg/L PBTK NA 50% Human Human +DTXSID0057758 Css NA 8.369 mg/L PBTK NA 95% Human Human +DTXSID0057758 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057758 Fup 0.0238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057758 Vd NA 2.216 L/kg 1compartment NA NA Rat Human +DTXSID0057758 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID0057758 TK.Half.Life NA 8.44 hours 1compartment NA NA Rat Human +DTXSID0057758 Css NA 0.2535 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057758 Css NA 1.452 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057758 Css NA 0.1718 mg/L PBTK NA 50% Rat Human +DTXSID0057758 Css NA 0.9516 mg/L PBTK NA 95% Rat Human +DTXSID0057831 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057831 Fup 0.09 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057831 Vd NA 1.579 L/kg 1compartment NA NA Human Human +DTXSID0057831 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID0057831 TK.Half.Life NA 13.04 hours 1compartment NA NA Human Human +DTXSID0057831 Css NA 1.133 mg/L 3compartmentss NA 50% Human Human +DTXSID0057831 Css NA 7.37 mg/L 3compartmentss NA 95% Human Human +DTXSID0057831 Css NA 0.7536 mg/L PBTK NA 50% Human Human +DTXSID0057831 Css NA 4.581 mg/L PBTK NA 95% Human Human +DTXSID0057831 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057831 Fup 0.09 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057831 Vd NA 1.214 L/kg 1compartment NA NA Rat Human DTXSID0057831 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057831 TK.Half.Life NA 3.847 hours 1compartment NA NA Rat Human -DTXSID0057831 Css NA 0.5544 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057831 Css NA 2.848 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057831 Css NA 0.3365 mg/L PBTK NA 50% Rat Human -DTXSID0057831 Css NA 1.634 mg/L PBTK NA 95% Rat Human -DTXSID0057833 Clint NA 56.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057833 Fup NA 0.2947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057833 Vd NA 1.247 L/kg 1compartment NA NA Human Human +DTXSID0057831 TK.Half.Life NA 4.951 hours 1compartment NA NA Rat Human +DTXSID0057831 Css NA 0.1386 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057831 Css NA 0.6703 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057831 Css NA 0.09007 mg/L PBTK NA 50% Rat Human +DTXSID0057831 Css NA 0.4028 mg/L PBTK NA 95% Rat Human +DTXSID0057833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057833 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057833 Vd NA 1.93 L/kg 1compartment NA NA Human Human DTXSID0057833 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057833 TK.Half.Life NA 1.21 hours 1compartment NA NA Human Human -DTXSID0057833 Css NA 0.02981 mg/L 3compartmentss NA 50% Human Human -DTXSID0057833 Css NA 0.2208 mg/L 3compartmentss NA 95% Human Human -DTXSID0057833 Css NA 0.02248 mg/L PBTK NA 50% Human Human -DTXSID0057833 Css NA 0.1563 mg/L PBTK NA 95% Human Human -DTXSID0057833 Clint NA 56.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057833 Fup NA 0.2947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057833 Vd NA 1.033 L/kg 1compartment NA NA Rat Human +DTXSID0057833 TK.Half.Life NA 2.721 hours 1compartment NA NA Human Human +DTXSID0057833 Css NA 0.08124 mg/L 3compartmentss NA 50% Human Human +DTXSID0057833 Css NA 0.5615 mg/L 3compartmentss NA 95% Human Human +DTXSID0057833 Css NA 0.06311 mg/L PBTK NA 50% Human Human +DTXSID0057833 Css NA 0.3998 mg/L PBTK NA 95% Human Human +DTXSID0057833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057833 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057833 Vd NA 1.529 L/kg 1compartment NA NA Rat Human DTXSID0057833 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057833 TK.Half.Life NA 0.4764 hours 1compartment NA NA Rat Human -DTXSID0057833 Css NA 0.01665 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057833 Css NA 0.09876 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057833 Css NA 0.01192 mg/L PBTK NA 50% Rat Human -DTXSID0057833 Css NA 0.06642 mg/L PBTK NA 95% Rat Human -DTXSID0057835 Clint NA 32.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057835 Fup NA 0.2802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057835 Vd NA 0.8421 L/kg 1compartment NA NA Human Human +DTXSID0057833 TK.Half.Life NA 0.975 hours 1compartment NA NA Rat Human +DTXSID0057833 Css NA 0.009927 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057833 Css NA 0.05448 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057833 Css NA 0.007742 mg/L PBTK NA 50% Rat Human +DTXSID0057833 Css NA 0.03839 mg/L PBTK NA 95% Rat Human +DTXSID0057835 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057835 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057835 Vd NA 0.4837 L/kg 1compartment NA NA Human Human DTXSID0057835 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057835 TK.Half.Life NA 0.9583 hours 1compartment NA NA Human Human -DTXSID0057835 Css NA 0.04996 mg/L 3compartmentss NA 50% Human Human -DTXSID0057835 Css NA 0.3924 mg/L 3compartmentss NA 95% Human Human -DTXSID0057835 Css NA 0.0367 mg/L PBTK NA 50% Human Human -DTXSID0057835 Css NA 0.2599 mg/L PBTK NA 95% Human Human -DTXSID0057835 Clint NA 32.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057835 Fup NA 0.2802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057835 Vd NA 0.8392 L/kg 1compartment NA NA Rat Human +DTXSID0057835 TK.Half.Life NA 1.207 hours 1compartment NA NA Human Human +DTXSID0057835 Css NA 0.191 mg/L 3compartmentss NA 50% Human Human +DTXSID0057835 Css NA 1.208 mg/L 3compartmentss NA 95% Human Human +DTXSID0057835 Css NA 0.1339 mg/L PBTK NA 50% Human Human +DTXSID0057835 Css NA 0.7767 mg/L PBTK NA 95% Human Human +DTXSID0057835 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057835 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057835 Vd NA 0.485 L/kg 1compartment NA NA Rat Human DTXSID0057835 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057835 TK.Half.Life NA 0.494 hours 1compartment NA NA Rat Human -DTXSID0057835 Css NA 0.02744 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057835 Css NA 0.1572 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057835 Css NA 0.0191 mg/L PBTK NA 50% Rat Human -DTXSID0057835 Css NA 0.101 mg/L PBTK NA 95% Rat Human -DTXSID0057837 Clint NA 0.4926 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057837 Fup NA 0.1136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057837 Vd NA 0.3656 L/kg 1compartment NA NA Human Human -DTXSID0057837 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID0057837 TK.Half.Life NA 11.51 hours 1compartment NA NA Human Human -DTXSID0057837 Css NA 4.659 mg/L 3compartmentss NA 50% Human Human -DTXSID0057837 Css NA 23.23 mg/L 3compartmentss NA 95% Human Human -DTXSID0057837 Css NA 2.966 mg/L PBTK NA 50% Human Human -DTXSID0057837 Css NA 13.85 mg/L PBTK NA 95% Human Human -DTXSID0057837 Clint NA 0.4926 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057837 Fup NA 0.1136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057837 Vd NA 0.3637 L/kg 1compartment NA NA Rat Human +DTXSID0057835 TK.Half.Life NA 0.6883 hours 1compartment NA NA Rat Human +DTXSID0057835 Css NA 0.008316 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057835 Css NA 0.06228 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057835 Css NA 0.005754 mg/L PBTK NA 50% Rat Human +DTXSID0057835 Css NA 0.03916 mg/L PBTK NA 95% Rat Human +DTXSID0057837 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057837 Fup 0.226 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057837 Vd NA 0.4975 L/kg 1compartment NA NA Human Human +DTXSID0057837 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0057837 TK.Half.Life NA 1.575 hours 1compartment NA NA Human Human +DTXSID0057837 Css NA 0.3004 mg/L 3compartmentss NA 50% Human Human +DTXSID0057837 Css NA 1.864 mg/L 3compartmentss NA 95% Human Human +DTXSID0057837 Css NA 0.2092 mg/L PBTK NA 50% Human Human +DTXSID0057837 Css NA 1.222 mg/L PBTK NA 95% Human Human +DTXSID0057837 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057837 Fup 0.226 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057837 Vd NA 0.4989 L/kg 1compartment NA NA Rat Human DTXSID0057837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057837 TK.Half.Life NA 5.063 hours 1compartment NA NA Rat Human -DTXSID0057837 Css NA 1.729 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057837 Css NA 7.439 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057837 Css NA 1.034 mg/L PBTK NA 50% Rat Human -DTXSID0057837 Css NA 4.111 mg/L PBTK NA 95% Rat Human -DTXSID0057839 Clint NA 10.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057839 Fup NA 0.1391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID0057839 Vd NA 2.19 L/kg 1compartment NA NA Human Human +DTXSID0057837 TK.Half.Life NA 0.9236 hours 1compartment NA NA Rat Human +DTXSID0057837 Css NA 0.0359 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057837 Css NA 0.1553 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057837 Css NA 0.02473 mg/L PBTK NA 50% Rat Human +DTXSID0057837 Css NA 0.09852 mg/L PBTK NA 95% Rat Human +DTXSID0057839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057839 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057839 Vd NA 2.61 L/kg 1compartment NA NA Human Human DTXSID0057839 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID0057839 TK.Half.Life NA 6.583 hours 1compartment NA NA Human Human -DTXSID0057839 Css NA 0.2956 mg/L 3compartmentss NA 50% Human Human -DTXSID0057839 Css NA 2.401 mg/L 3compartmentss NA 95% Human Human -DTXSID0057839 Css NA 0.2418 mg/L PBTK NA 50% Human Human -DTXSID0057839 Css NA 1.662 mg/L PBTK NA 95% Human Human -DTXSID0057839 Clint NA 10.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057839 Fup NA 0.1391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID0057839 Vd NA 2.099 L/kg 1compartment NA NA Rat Human +DTXSID0057839 TK.Half.Life NA 3.947 hours 1compartment NA NA Human Human +DTXSID0057839 Css NA 0.08718 mg/L 3compartmentss NA 50% Human Human +DTXSID0057839 Css NA 0.6729 mg/L 3compartmentss NA 95% Human Human +DTXSID0057839 Css NA 0.07954 mg/L PBTK NA 50% Human Human +DTXSID0057839 Css NA 0.5392 mg/L PBTK NA 95% Human Human +DTXSID0057839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057839 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057839 Vd NA 2.504 L/kg 1compartment NA NA Rat Human DTXSID0057839 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID0057839 TK.Half.Life NA 3.631 hours 1compartment NA NA Rat Human -DTXSID0057839 Css NA 0.1607 mg/L 3compartmentss NA 50% Rat Human -DTXSID0057839 Css NA 0.9617 mg/L 3compartmentss NA 95% Rat Human -DTXSID0057839 Css NA 0.1258 mg/L PBTK NA 50% Rat Human -DTXSID0057839 Css NA 0.6357 mg/L PBTK NA 95% Rat Human +DTXSID0057839 TK.Half.Life NA 2.046 hours 1compartment NA NA Rat Human +DTXSID0057839 Css NA 0.01082 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057839 Css NA 0.06474 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057839 Css NA 0.00999 mg/L PBTK NA 50% Rat Human +DTXSID0057839 Css NA 0.05166 mg/L PBTK NA 95% Rat Human +DTXSID0057883 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057883 Fup 0.34 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0057883 Vd NA 1.724 L/kg 1compartment NA NA Human Human +DTXSID0057883 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0057883 TK.Half.Life NA 4.767 hours 1compartment NA NA Human Human +DTXSID0057883 Css NA 0.2366 mg/L 3compartmentss NA 50% Human Human +DTXSID0057883 Css NA 1.497 mg/L 3compartmentss NA 95% Human Human +DTXSID0057883 Css NA 0.1839 mg/L PBTK NA 50% Human Human +DTXSID0057883 Css NA 1.044 mg/L PBTK NA 95% Human Human +DTXSID0057883 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057883 Fup 0.34 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0057883 Vd NA 1.384 L/kg 1compartment NA NA Rat Human +DTXSID0057883 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0057883 TK.Half.Life NA 1.815 hours 1compartment NA NA Rat Human +DTXSID0057883 Css NA 0.02767 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057883 Css NA 0.1258 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057883 Css NA 0.02156 mg/L PBTK NA 50% Rat Human +DTXSID0057883 Css NA 0.08631 mg/L PBTK NA 95% Rat Human +DTXSID0057887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057887 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0057887 Vd NA 1.08 L/kg 1compartment NA NA Human Human +DTXSID0057887 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID0057887 TK.Half.Life NA 16.78 hours 1compartment NA NA Human Human +DTXSID0057887 Css NA 1.558 mg/L 3compartmentss NA 50% Human Human +DTXSID0057887 Css NA 7.358 mg/L 3compartmentss NA 95% Human Human +DTXSID0057887 Css NA 1.258 mg/L PBTK NA 50% Human Human +DTXSID0057887 Css NA 4.81 mg/L PBTK NA 95% Human Human +DTXSID0057887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057887 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0057887 Vd NA 0.9664 L/kg 1compartment NA NA Rat Human +DTXSID0057887 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0057887 TK.Half.Life NA 4.851 hours 1compartment NA NA Rat Human +DTXSID0057887 Css NA 0.09846 mg/L 3compartmentss NA 50% Rat Human +DTXSID0057887 Css NA 0.4006 mg/L 3compartmentss NA 95% Rat Human +DTXSID0057887 Css NA 0.0791 mg/L PBTK NA 50% Rat Human +DTXSID0057887 Css NA 0.2543 mg/L PBTK NA 95% Rat Human +DTXSID0058699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0058699 Fup 0.0238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0058699 Vd NA 3.09 L/kg 1compartment NA NA Human Human +DTXSID0058699 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID0058699 TK.Half.Life NA 76.25 hours 1compartment NA NA Human Human +DTXSID0058699 Css NA 2.93 mg/L 3compartmentss NA 50% Human Human +DTXSID0058699 Css NA 18.94 mg/L 3compartmentss NA 95% Human Human +DTXSID0058699 Css NA 2.035 mg/L PBTK NA 50% Human Human +DTXSID0058699 Css NA 12.64 mg/L PBTK NA 95% Human Human +DTXSID0058699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0058699 Fup 0.0238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0058699 Vd NA 2.315 L/kg 1compartment NA NA Rat Human +DTXSID0058699 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID0058699 TK.Half.Life NA 10.77 hours 1compartment NA NA Rat Human +DTXSID0058699 Css NA 0.3853 mg/L 3compartmentss NA 50% Rat Human +DTXSID0058699 Css NA 2.174 mg/L 3compartmentss NA 95% Rat Human +DTXSID0058699 Css NA 0.2634 mg/L PBTK NA 50% Rat Human +DTXSID0058699 Css NA 1.435 mg/L PBTK NA 95% Rat Human +DTXSID0058720 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0058720 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID0058720 Vd NA 2.601 L/kg 1compartment NA NA Human Human +DTXSID0058720 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0058720 TK.Half.Life NA 2.646 hours 1compartment NA NA Human Human +DTXSID0058720 Css NA 0.06115 mg/L 3compartmentss NA 50% Human Human +DTXSID0058720 Css NA 0.4227 mg/L 3compartmentss NA 95% Human Human +DTXSID0058720 Css NA 0.06626 mg/L PBTK NA 50% Human Human +DTXSID0058720 Css NA 0.4593 mg/L PBTK NA 95% Human Human +DTXSID0058720 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0058720 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID0058720 Vd NA 2.595 L/kg 1compartment NA NA Rat Human +DTXSID0058720 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0058720 TK.Half.Life NA 1.367 hours 1compartment NA NA Rat Human +DTXSID0058720 Css NA 0.00666 mg/L 3compartmentss NA 50% Rat Human +DTXSID0058720 Css NA 0.03713 mg/L 3compartmentss NA 95% Rat Human +DTXSID0058720 Css NA 0.007524 mg/L PBTK NA 50% Rat Human +DTXSID0058720 Css NA 0.04192 mg/L PBTK NA 95% Rat Human +DTXSID0060800 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0060800 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID0060800 Vd NA 0.8181 L/kg 1compartment NA NA Human Human +DTXSID0060800 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID0060800 TK.Half.Life NA 8.891 hours 1compartment NA NA Human Human +DTXSID0060800 Css NA 1.008 mg/L 3compartmentss NA 50% Human Human +DTXSID0060800 Css NA 7.3 mg/L 3compartmentss NA 95% Human Human +DTXSID0060800 Css NA 0.8326 mg/L PBTK NA 50% Human Human +DTXSID0060800 Css NA 4.572 mg/L PBTK NA 95% Human Human +DTXSID0060800 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0060800 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID0060800 Vd NA 0.8002 L/kg 1compartment NA NA Rat Human +DTXSID0060800 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID0060800 TK.Half.Life NA 2.932 hours 1compartment NA NA Rat Human +DTXSID0060800 Css NA 0.0196 mg/L 3compartmentss NA 50% Rat Human +DTXSID0060800 Css NA 0.1696 mg/L 3compartmentss NA 95% Rat Human +DTXSID0060800 Css NA 0.01552 mg/L PBTK NA 50% Rat Human +DTXSID0060800 Css NA 0.1063 mg/L PBTK NA 95% Rat Human +DTXSID00622706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00622706 Fup 0.0198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00622706 Vd NA 17.62 L/kg 1compartment NA NA Human Human +DTXSID00622706 Days.Css NA 66 Days PBTK NA NA Human Human +DTXSID00622706 TK.Half.Life NA 318.7 hours 1compartment NA NA Human Human +DTXSID00622706 Css NA 0.883 mg/L 3compartmentss NA 50% Human Human +DTXSID00622706 Css NA 7 mg/L 3compartmentss NA 95% Human Human +DTXSID00622706 Css NA 1.6 mg/L PBTK NA 50% Human Human +DTXSID00622706 Css NA 10.01 mg/L PBTK NA 95% Human Human +DTXSID00622706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00622706 Fup 0.0198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00622706 Vd NA 14.22 L/kg 1compartment NA NA Rat Human +DTXSID00622706 Days.Css NA 40 Days PBTK NA NA Rat Human +DTXSID00622706 TK.Half.Life NA 56.45 hours 1compartment NA NA Rat Human +DTXSID00622706 Css NA 0.1056 mg/L 3compartmentss NA 50% Rat Human +DTXSID00622706 Css NA 0.7397 mg/L 3compartmentss NA 95% Rat Human +DTXSID00622706 Css NA 0.2056 mg/L PBTK NA 50% Rat Human +DTXSID00622706 Css NA 1.121 mg/L PBTK NA 95% Rat Human +DTXSID00676880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00676880 Fup 0.0855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00676880 Vd NA 1.66 L/kg 1compartment NA NA Human Human +DTXSID00676880 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00676880 TK.Half.Life NA 3.48 hours 1compartment NA NA Human Human +DTXSID00676880 Css NA 0.1926 mg/L 3compartmentss NA 50% Human Human +DTXSID00676880 Css NA 1.811 mg/L 3compartmentss NA 95% Human Human +DTXSID00676880 Css NA 0.15 mg/L PBTK NA 50% Human Human +DTXSID00676880 Css NA 1.221 mg/L PBTK NA 95% Human Human +DTXSID00676880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00676880 Fup 0.0855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00676880 Vd NA 1.638 L/kg 1compartment NA NA Rat Human +DTXSID00676880 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00676880 TK.Half.Life NA 2.068 hours 1compartment NA NA Rat Human +DTXSID00676880 Css NA 0.02472 mg/L 3compartmentss NA 50% Rat Human +DTXSID00676880 Css NA 0.1797 mg/L 3compartmentss NA 95% Rat Human +DTXSID00676880 Css NA 0.01915 mg/L PBTK NA 50% Rat Human +DTXSID00676880 Css NA 0.1217 mg/L PBTK NA 95% Rat Human +DTXSID00677236 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00677236 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00677236 Vd NA 0.973 L/kg 1compartment NA NA Human Human +DTXSID00677236 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00677236 TK.Half.Life NA 1.718 hours 1compartment NA NA Human Human +DTXSID00677236 Css NA 0.1241 mg/L 3compartmentss NA 50% Human Human +DTXSID00677236 Css NA 0.9152 mg/L 3compartmentss NA 95% Human Human +DTXSID00677236 Css NA 0.08594 mg/L PBTK NA 50% Human Human +DTXSID00677236 Css NA 0.6014 mg/L PBTK NA 95% Human Human +DTXSID00677236 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00677236 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00677236 Vd NA 0.8007 L/kg 1compartment NA NA Rat Human +DTXSID00677236 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00677236 TK.Half.Life NA 0.7607 hours 1compartment NA NA Rat Human +DTXSID00677236 Css NA 0.01606 mg/L 3compartmentss NA 50% Rat Human +DTXSID00677236 Css NA 0.0867 mg/L 3compartmentss NA 95% Rat Human +DTXSID00677236 Css NA 0.0109 mg/L PBTK NA 50% Rat Human +DTXSID00677236 Css NA 0.05594 mg/L PBTK NA 95% Rat Human +DTXSID00858846 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00858846 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00858846 Vd NA 13.53 L/kg 1compartment NA NA Human Human +DTXSID00858846 Days.Css NA 84 Days PBTK NA NA Human Human +DTXSID00858846 TK.Half.Life NA 387.2 hours 1compartment NA NA Human Human +DTXSID00858846 Css NA 0.8772 mg/L 3compartmentss NA 50% Human Human +DTXSID00858846 Css NA 6.731 mg/L 3compartmentss NA 95% Human Human +DTXSID00858846 Css NA 1.304 mg/L PBTK NA 50% Human Human +DTXSID00858846 Css NA 8.554 mg/L PBTK NA 95% Human Human +DTXSID00858846 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00858846 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00858846 Vd NA 10.79 L/kg 1compartment NA NA Rat Human +DTXSID00858846 Days.Css NA 51 Days PBTK NA NA Rat Human +DTXSID00858846 TK.Half.Life NA 55.1 hours 1compartment NA NA Rat Human +DTXSID00858846 Css NA 0.009126 mg/L 3compartmentss NA 50% Rat Human +DTXSID00858846 Css NA 0.05966 mg/L 3compartmentss NA 95% Rat Human +DTXSID00858846 Css NA 0.01384 mg/L PBTK NA 50% Rat Human +DTXSID00858846 Css NA 0.0834 mg/L PBTK NA 95% Rat Human DTXSID00859151 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID00859151 Fup NA 0.2428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID00859151 Vd NA 0.4599 L/kg 1compartment NA NA Human Human +DTXSID00859151 Vd NA 0.4136 L/kg 1compartment NA NA Human Human DTXSID00859151 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID00859151 TK.Half.Life NA 12.26 hours 1compartment NA NA Human Human -DTXSID00859151 Css NA 3.137 mg/L 3compartmentss NA 50% Human Human -DTXSID00859151 Css NA 12.12 mg/L 3compartmentss NA 95% Human Human -DTXSID00859151 Css NA 2.164 mg/L PBTK NA 50% Human Human -DTXSID00859151 Css NA 7.494 mg/L PBTK NA 95% Human Human +DTXSID00859151 TK.Half.Life NA 11.02 hours 1compartment NA NA Human Human +DTXSID00859151 Css NA 2.749 mg/L 3compartmentss NA 50% Human Human +DTXSID00859151 Css NA 10.5 mg/L 3compartmentss NA 95% Human Human +DTXSID00859151 Css NA 1.874 mg/L PBTK NA 50% Human Human +DTXSID00859151 Css NA 6.414 mg/L PBTK NA 95% Human Human DTXSID00859151 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID00859151 Fup NA 0.2428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID00859151 Vd NA 0.4643 L/kg 1compartment NA NA Rat Human +DTXSID00859151 Vd NA 0.4216 L/kg 1compartment NA NA Rat Human DTXSID00859151 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID00859151 TK.Half.Life NA 4.216 hours 1compartment NA NA Rat Human -DTXSID00859151 Css NA 0.8684 mg/L 3compartmentss NA 50% Rat Human -DTXSID00859151 Css NA 2.752 mg/L 3compartmentss NA 95% Rat Human -DTXSID00859151 Css NA 0.5715 mg/L PBTK NA 50% Rat Human -DTXSID00859151 Css NA 1.602 mg/L PBTK NA 95% Rat Human +DTXSID00859151 TK.Half.Life NA 3.83 hours 1compartment NA NA Rat Human +DTXSID00859151 Css NA 0.0656 mg/L 3compartmentss NA 50% Rat Human +DTXSID00859151 Css NA 0.3589 mg/L 3compartmentss NA 95% Rat Human +DTXSID00859151 Css NA 0.04348 mg/L PBTK NA 50% Rat Human +DTXSID00859151 Css NA 0.2199 mg/L PBTK NA 95% Rat Human +DTXSID00860388 Clint 1.432 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00860388 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00860388 Vd NA 3.943 L/kg 1compartment NA NA Human Human +DTXSID00860388 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID00860388 TK.Half.Life NA 19.01 hours 1compartment NA NA Human Human +DTXSID00860388 Css NA 0.297 mg/L 3compartmentss NA 50% Human Human +DTXSID00860388 Css NA 1.994 mg/L 3compartmentss NA 95% Human Human +DTXSID00860388 Css NA 0.3844 mg/L PBTK NA 50% Human Human +DTXSID00860388 Css NA 1.738 mg/L PBTK NA 95% Human Human +DTXSID00860388 Clint 1.432 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00860388 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00860388 Vd NA 4.004 L/kg 1compartment NA NA Rat Human +DTXSID00860388 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID00860388 TK.Half.Life NA 9.948 hours 1compartment NA NA Rat Human +DTXSID00860388 Css NA 0.0283 mg/L 3compartmentss NA 50% Rat Human +DTXSID00860388 Css NA 0.1615 mg/L 3compartmentss NA 95% Rat Human +DTXSID00860388 Css NA 0.03794 mg/L PBTK NA 50% Rat Human +DTXSID00860388 Css NA 0.1325 mg/L PBTK NA 95% Rat Human +DTXSID00861411 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00861411 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00861411 Vd NA 3.096 L/kg 1compartment NA NA Human Human +DTXSID00861411 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID00861411 TK.Half.Life NA 65.7 hours 1compartment NA NA Human Human +DTXSID00861411 Css NA 1.591 mg/L 3compartmentss NA 50% Human Human +DTXSID00861411 Css NA 10.97 mg/L 3compartmentss NA 95% Human Human +DTXSID00861411 Css NA 1.109 mg/L PBTK NA 50% Human Human +DTXSID00861411 Css NA 7.42 mg/L PBTK NA 95% Human Human DTXSID00861411 Clint 21.04 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID00861411 Fup 0.34 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID00861411 Vd NA 2.347 L/kg 1compartment NA NA Rat Rat -DTXSID00861411 Days.Css NA 2 Days PBTK NA NA Rat Rat -DTXSID00861411 TK.Half.Life NA 5.8 hours 1compartment NA NA Rat Rat -DTXSID00861411 Css NA 0.8233 mg/L 3compartmentss NA 50% Rat Rat -DTXSID00861411 Css NA 4.264 mg/L 3compartmentss NA 95% Rat Rat -DTXSID00861411 Css NA 0.5544 mg/L PBTK NA 50% Rat Rat -DTXSID00861411 Css NA 2.78 mg/L PBTK NA 95% Rat Rat +DTXSID00861411 Vd NA 2.352 L/kg 1compartment NA NA Rat Rat +DTXSID00861411 Days.Css NA 5 Days PBTK NA NA Rat Rat +DTXSID00861411 TK.Half.Life NA 9.093 hours 1compartment NA NA Rat Rat +DTXSID00861411 Css NA 0.02001 mg/L 3compartmentss NA 50% Rat Rat +DTXSID00861411 Css NA 0.1454 mg/L 3compartmentss NA 95% Rat Rat +DTXSID00861411 Css NA 0.01343 mg/L PBTK NA 50% Rat Rat +DTXSID00861411 Css NA 0.09442 mg/L PBTK NA 95% Rat Rat +DTXSID00861835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00861835 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00861835 Vd NA 0.5186 L/kg 1compartment NA NA Human Human +DTXSID00861835 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00861835 TK.Half.Life NA 2.64 hours 1compartment NA NA Human Human +DTXSID00861835 Css NA 0.7757 mg/L 3compartmentss NA 50% Human Human +DTXSID00861835 Css NA 7.434 mg/L 3compartmentss NA 95% Human Human +DTXSID00861835 Css NA 0.4668 mg/L PBTK NA 50% Human Human +DTXSID00861835 Css NA 4.385 mg/L PBTK NA 95% Human Human +DTXSID00861835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00861835 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00861835 Vd NA 0.4144 L/kg 1compartment NA NA Rat Human +DTXSID00861835 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00861835 TK.Half.Life NA 1.31 hours 1compartment NA NA Rat Human +DTXSID00861835 Css NA 0.1021 mg/L 3compartmentss NA 50% Rat Human +DTXSID00861835 Css NA 0.7543 mg/L 3compartmentss NA 95% Rat Human +DTXSID00861835 Css NA 0.05959 mg/L PBTK NA 50% Rat Human +DTXSID00861835 Css NA 0.429 mg/L PBTK NA 95% Rat Human +DTXSID00862685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00862685 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00862685 Vd NA 3.061 L/kg 1compartment NA NA Human Human +DTXSID00862685 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID00862685 TK.Half.Life NA 77.21 hours 1compartment NA NA Human Human +DTXSID00862685 Css NA 3.077 mg/L 3compartmentss NA 50% Human Human +DTXSID00862685 Css NA 19.83 mg/L 3compartmentss NA 95% Human Human +DTXSID00862685 Css NA 2.118 mg/L PBTK NA 50% Human Human +DTXSID00862685 Css NA 13.29 mg/L PBTK NA 95% Human Human +DTXSID00862685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00862685 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00862685 Vd NA 2.292 L/kg 1compartment NA NA Rat Human +DTXSID00862685 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID00862685 TK.Half.Life NA 11.3 hours 1compartment NA NA Rat Human +DTXSID00862685 Css NA 0.3994 mg/L 3compartmentss NA 50% Rat Human +DTXSID00862685 Css NA 2.24 mg/L 3compartmentss NA 95% Rat Human +DTXSID00862685 Css NA 0.2712 mg/L PBTK NA 50% Rat Human +DTXSID00862685 Css NA 1.469 mg/L PBTK NA 95% Rat Human +DTXSID00866067 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00866067 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00866067 Vd NA 0.2804 L/kg 1compartment NA NA Human Human +DTXSID00866067 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00866067 TK.Half.Life NA 0.944 hours 1compartment NA NA Human Human +DTXSID00866067 Css NA 0.1811 mg/L 3compartmentss NA 50% Human Human +DTXSID00866067 Css NA 1.212 mg/L 3compartmentss NA 95% Human Human +DTXSID00866067 Css NA 0.1155 mg/L PBTK NA 50% Human Human +DTXSID00866067 Css NA 0.7434 mg/L PBTK NA 95% Human Human +DTXSID00866067 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00866067 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00866067 Vd NA 0.2849 L/kg 1compartment NA NA Rat Human +DTXSID00866067 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00866067 TK.Half.Life NA 0.5585 hours 1compartment NA NA Rat Human +DTXSID00866067 Css NA 0.001788 mg/L 3compartmentss NA 50% Rat Human +DTXSID00866067 Css NA 0.009933 mg/L 3compartmentss NA 95% Rat Human +DTXSID00866067 Css NA 0.001075 mg/L PBTK NA 50% Rat Human +DTXSID00866067 Css NA 0.005753 mg/L PBTK NA 95% Rat Human +DTXSID00867110 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00867110 Fup 0.78 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00867110 Vd NA 0.4499 L/kg 1compartment NA NA Human Human +DTXSID00867110 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00867110 TK.Half.Life NA 3.731 hours 1compartment NA NA Human Human +DTXSID00867110 Css NA 0.6187 mg/L 3compartmentss NA 50% Human Human +DTXSID00867110 Css NA 3.77 mg/L 3compartmentss NA 95% Human Human +DTXSID00867110 Css NA 0.456 mg/L PBTK NA 50% Human Human +DTXSID00867110 Css NA 2.302 mg/L PBTK NA 95% Human Human +DTXSID00867110 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00867110 Fup 0.78 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00867110 Vd NA 0.4693 L/kg 1compartment NA NA Rat Human +DTXSID00867110 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00867110 TK.Half.Life NA 1.327 hours 1compartment NA NA Rat Human +DTXSID00867110 Css NA 0.003159 mg/L 3compartmentss NA 50% Rat Human +DTXSID00867110 Css NA 0.0195 mg/L 3compartmentss NA 95% Rat Human +DTXSID00867110 Css NA 0.002232 mg/L PBTK NA 50% Rat Human +DTXSID00867110 Css NA 0.01167 mg/L PBTK NA 95% Rat Human +DTXSID00868985 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00868985 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00868985 Vd NA 0.3844 L/kg 1compartment NA NA Human Human +DTXSID00868985 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00868985 TK.Half.Life NA 6.25 hours 1compartment NA NA Human Human +DTXSID00868985 Css NA 1.038 mg/L 3compartmentss NA 50% Human Human +DTXSID00868985 Css NA 4.735 mg/L 3compartmentss NA 95% Human Human +DTXSID00868985 Css NA 0.7151 mg/L PBTK NA 50% Human Human +DTXSID00868985 Css NA 2.925 mg/L PBTK NA 95% Human Human +DTXSID00868985 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00868985 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00868985 Vd NA 0.3894 L/kg 1compartment NA NA Rat Human +DTXSID00868985 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00868985 TK.Half.Life NA 2.157 hours 1compartment NA NA Rat Human +DTXSID00868985 Css NA 0.005629 mg/L 3compartmentss NA 50% Rat Human +DTXSID00868985 Css NA 0.02547 mg/L 3compartmentss NA 95% Rat Human +DTXSID00868985 Css NA 0.003706 mg/L PBTK NA 50% Rat Human +DTXSID00868985 Css NA 0.01503 mg/L PBTK NA 95% Rat Human +DTXSID00870104 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00870104 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00870104 Vd NA 2.136 L/kg 1compartment NA NA Human Human +DTXSID00870104 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00870104 TK.Half.Life NA 4.844 hours 1compartment NA NA Human Human +DTXSID00870104 Css NA 0.2064 mg/L 3compartmentss NA 50% Human Human +DTXSID00870104 Css NA 1.636 mg/L 3compartmentss NA 95% Human Human +DTXSID00870104 Css NA 0.1546 mg/L PBTK NA 50% Human Human +DTXSID00870104 Css NA 1.11 mg/L PBTK NA 95% Human Human +DTXSID00870104 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00870104 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00870104 Vd NA 1.86 L/kg 1compartment NA NA Rat Human +DTXSID00870104 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00870104 TK.Half.Life NA 2.154 hours 1compartment NA NA Rat Human +DTXSID00870104 Css NA 0.0263 mg/L 3compartmentss NA 50% Rat Human +DTXSID00870104 Css NA 0.1667 mg/L 3compartmentss NA 95% Rat Human +DTXSID00870104 Css NA 0.01965 mg/L PBTK NA 50% Rat Human +DTXSID00870104 Css NA 0.1102 mg/L PBTK NA 95% Rat Human +DTXSID00870220 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00870220 Fup 0.63 NA NA https://doi.org/10.1002/bdd.711 NA Human Human +DTXSID00870220 Vd NA 1.441 L/kg 1compartment NA NA Human Human +DTXSID00870220 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00870220 TK.Half.Life NA 1.788 hours 1compartment NA NA Human Human +DTXSID00870220 Css NA 0.05648 mg/L 3compartmentss NA 50% Human Human +DTXSID00870220 Css NA 0.4157 mg/L 3compartmentss NA 95% Human Human +DTXSID00870220 Css NA 0.09004 mg/L PBTK NA 50% Human Human +DTXSID00870220 Css NA 0.6647 mg/L PBTK NA 95% Human Human DTXSID00870220 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID00870220 Fup 0.65 NA NA https://doi.org/10.1002/bdd.711 NA Rat Rat -DTXSID00870220 Vd NA 1.31 L/kg 1compartment NA NA Rat Rat +DTXSID00870220 Vd NA 1.362 L/kg 1compartment NA NA Rat Rat DTXSID00870220 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID00870220 TK.Half.Life NA 4.519 hours 1compartment NA NA Rat Rat -DTXSID00870220 Css NA 0.1711 mg/L 3compartmentss NA 50% Rat Rat -DTXSID00870220 Css NA 1.466 mg/L 3compartmentss NA 95% Rat Rat -DTXSID00870220 Css NA 0.2464 mg/L PBTK NA 50% Rat Rat -DTXSID00870220 Css NA 1.09 mg/L PBTK NA 95% Rat Rat +DTXSID00870220 TK.Half.Life NA 4.715 hours 1compartment NA NA Rat Rat +DTXSID00870220 Css NA 0.0349 mg/L 3compartmentss NA 50% Rat Rat +DTXSID00870220 Css NA 0.1573 mg/L 3compartmentss NA 95% Rat Rat +DTXSID00870220 Css NA 0.05782 mg/L PBTK NA 50% Rat Rat +DTXSID00870220 Css NA 0.2607 mg/L PBTK NA 95% Rat Rat DTXSID00872663 Clint 112 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID00872663 Fup 3.08e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID00872663 Vd NA 0.1833 L/kg 1compartment NA NA Human Human -DTXSID00872663 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID00872663 TK.Half.Life NA 46.46 hours 1compartment NA NA Human Human -DTXSID00872663 Css NA 16.62 mg/L 3compartmentss NA 50% Human Human -DTXSID00872663 Css NA 119.5 mg/L 3compartmentss NA 95% Human Human -DTXSID00872663 Css NA 9.712 mg/L PBTK NA 50% Human Human -DTXSID00872663 Css NA 69.44 mg/L PBTK NA 95% Human Human +DTXSID00872663 Vd NA 0.1685 L/kg 1compartment NA NA Human Human +DTXSID00872663 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID00872663 TK.Half.Life NA 49.12 hours 1compartment NA NA Human Human +DTXSID00872663 Css NA 18.68 mg/L 3compartmentss NA 50% Human Human +DTXSID00872663 Css NA 142.8 mg/L 3compartmentss NA 95% Human Human +DTXSID00872663 Css NA 10.94 mg/L PBTK NA 50% Human Human +DTXSID00872663 Css NA 82.29 mg/L PBTK NA 95% Human Human DTXSID00872663 Clint 112 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID00872663 Fup 3.08e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID00872663 Vd NA 0.1698 L/kg 1compartment NA NA Rat Human -DTXSID00872663 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID00872663 TK.Half.Life NA 30.06 hours 1compartment NA NA Rat Human -DTXSID00872663 Css NA 11.77 mg/L 3compartmentss NA 50% Rat Human -DTXSID00872663 Css NA 48.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID00872663 Css NA 6.364 mg/L PBTK NA 50% Rat Human -DTXSID00872663 Css NA 26.22 mg/L PBTK NA 95% Rat Human -DTXSID00904978 Clint NA 17.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID00904978 Fup NA 0.1463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID00904978 Vd NA 0.7188 L/kg 1compartment NA NA Human Human +DTXSID00872663 Vd NA 0.1623 L/kg 1compartment NA NA Rat Human +DTXSID00872663 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID00872663 TK.Half.Life NA 33.02 hours 1compartment NA NA Rat Human +DTXSID00872663 Css NA 3.043 mg/L 3compartmentss NA 50% Rat Human +DTXSID00872663 Css NA 13.44 mg/L 3compartmentss NA 95% Rat Human +DTXSID00872663 Css NA 1.702 mg/L PBTK NA 50% Rat Human +DTXSID00872663 Css NA 7.523 mg/L PBTK NA 95% Rat Human +DTXSID00873377 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00873377 Fup 0.34 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00873377 Vd NA 2.266 L/kg 1compartment NA NA Human Human +DTXSID00873377 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00873377 TK.Half.Life NA 2.25 hours 1compartment NA NA Human Human +DTXSID00873377 Css NA 0.03305 mg/L 3compartmentss NA 50% Human Human +DTXSID00873377 Css NA 0.3113 mg/L 3compartmentss NA 95% Human Human +DTXSID00873377 Css NA 0.03283 mg/L PBTK NA 50% Human Human +DTXSID00873377 Css NA 0.2597 mg/L PBTK NA 95% Human Human +DTXSID00873377 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00873377 Fup 0.34 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00873377 Vd NA 2.265 L/kg 1compartment NA NA Rat Human +DTXSID00873377 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00873377 TK.Half.Life NA 1.227 hours 1compartment NA NA Rat Human +DTXSID00873377 Css NA 0.001116 mg/L 3compartmentss NA 50% Rat Human +DTXSID00873377 Css NA 0.0124 mg/L 3compartmentss NA 95% Rat Human +DTXSID00873377 Css NA 0.001136 mg/L PBTK NA 50% Rat Human +DTXSID00873377 Css NA 0.0102 mg/L PBTK NA 95% Rat Human +DTXSID00880006 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880006 Fup 0.0227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880006 Vd NA 2.369 L/kg 1compartment NA NA Human Human +DTXSID00880006 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID00880006 TK.Half.Life NA 16.31 hours 1compartment NA NA Human Human +DTXSID00880006 Css NA 0.919 mg/L 3compartmentss NA 50% Human Human +DTXSID00880006 Css NA 7.622 mg/L 3compartmentss NA 95% Human Human +DTXSID00880006 Css NA 0.6172 mg/L PBTK NA 50% Human Human +DTXSID00880006 Css NA 4.859 mg/L PBTK NA 95% Human Human +DTXSID00880006 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880006 Fup 0.0227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880006 Vd NA 1.843 L/kg 1compartment NA NA Rat Human +DTXSID00880006 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00880006 TK.Half.Life NA 5.188 hours 1compartment NA NA Rat Human +DTXSID00880006 Css NA 0.1184 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880006 Css NA 0.8352 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880006 Css NA 0.079 mg/L PBTK NA 50% Rat Human +DTXSID00880006 Css NA 0.5209 mg/L PBTK NA 95% Rat Human +DTXSID00880647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880647 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880647 Vd NA 2.985 L/kg 1compartment NA NA Human Human +DTXSID00880647 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID00880647 TK.Half.Life NA 19.46 hours 1compartment NA NA Human Human +DTXSID00880647 Css NA 0.6732 mg/L 3compartmentss NA 50% Human Human +DTXSID00880647 Css NA 4.271 mg/L 3compartmentss NA 95% Human Human +DTXSID00880647 Css NA 0.479 mg/L PBTK NA 50% Human Human +DTXSID00880647 Css NA 2.914 mg/L PBTK NA 95% Human Human +DTXSID00880647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880647 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880647 Vd NA 2.248 L/kg 1compartment NA NA Rat Human +DTXSID00880647 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID00880647 TK.Half.Life NA 3.495 hours 1compartment NA NA Rat Human +DTXSID00880647 Css NA 0.08734 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880647 Css NA 0.4363 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880647 Css NA 0.06166 mg/L PBTK NA 50% Rat Human +DTXSID00880647 Css NA 0.2978 mg/L PBTK NA 95% Rat Human +DTXSID00880662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880662 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880662 Vd NA 2.729 L/kg 1compartment NA NA Human Human +DTXSID00880662 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID00880662 TK.Half.Life NA 52.35 hours 1compartment NA NA Human Human +DTXSID00880662 Css NA 2.61 mg/L 3compartmentss NA 50% Human Human +DTXSID00880662 Css NA 18.05 mg/L 3compartmentss NA 95% Human Human +DTXSID00880662 Css NA 1.757 mg/L PBTK NA 50% Human Human +DTXSID00880662 Css NA 11.61 mg/L PBTK NA 95% Human Human +DTXSID00880662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880662 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880662 Vd NA 2.038 L/kg 1compartment NA NA Rat Human +DTXSID00880662 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID00880662 TK.Half.Life NA 10.82 hours 1compartment NA NA Rat Human +DTXSID00880662 Css NA 0.3388 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880662 Css NA 2.063 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880662 Css NA 0.2232 mg/L PBTK NA 50% Rat Human +DTXSID00880662 Css NA 1.339 mg/L PBTK NA 95% Rat Human +DTXSID00880682 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880682 Fup 0.0241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880682 Vd NA 236 L/kg 1compartment NA NA Human Human +DTXSID00880682 Days.Css NA 1877 Days PBTK NA NA Human Human +DTXSID00880682 TK.Half.Life NA 6925 hours 1compartment NA NA Human Human +DTXSID00880682 Css NA 0.03982 mg/L 3compartmentss NA 50% Human Human +DTXSID00880682 Css NA 0.2807 mg/L 3compartmentss NA 95% Human Human +DTXSID00880682 Css NA 1.297 mg/L PBTK NA 50% Human Human +DTXSID00880682 Css NA 8.148 mg/L PBTK NA 95% Human Human +DTXSID00880682 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880682 Fup 0.0241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880682 Vd NA 209.4 L/kg 1compartment NA NA Rat Human +DTXSID00880682 Days.Css NA 1182 Days PBTK NA NA Rat Human +DTXSID00880682 TK.Half.Life NA 1046 hours 1compartment NA NA Rat Human +DTXSID00880682 Css NA 0.0003899 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880682 Css NA 0.00241 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880682 Css NA 0.01369 mg/L PBTK NA 50% Rat Human +DTXSID00880682 Css NA 0.08243 mg/L PBTK NA 95% Rat Human +DTXSID00880743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880743 Fup 0.0669 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880743 Vd NA 2.989 L/kg 1compartment NA NA Human Human +DTXSID00880743 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID00880743 TK.Half.Life NA 35.4 hours 1compartment NA NA Human Human +DTXSID00880743 Css NA 1.394 mg/L 3compartmentss NA 50% Human Human +DTXSID00880743 Css NA 9.124 mg/L 3compartmentss NA 95% Human Human +DTXSID00880743 Css NA 0.969 mg/L PBTK NA 50% Human Human +DTXSID00880743 Css NA 6.082 mg/L PBTK NA 95% Human Human +DTXSID00880743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880743 Fup 0.0669 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880743 Vd NA 2.243 L/kg 1compartment NA NA Rat Human +DTXSID00880743 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID00880743 TK.Half.Life NA 5.909 hours 1compartment NA NA Rat Human +DTXSID00880743 Css NA 0.1795 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880743 Css NA 0.9738 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880743 Css NA 0.1233 mg/L PBTK NA 50% Rat Human +DTXSID00880743 Css NA 0.6404 mg/L PBTK NA 95% Rat Human +DTXSID00880763 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880763 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880763 Vd NA 2.18 L/kg 1compartment NA NA Human Human +DTXSID00880763 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00880763 TK.Half.Life NA 6.2 hours 1compartment NA NA Human Human +DTXSID00880763 Css NA 0.2826 mg/L 3compartmentss NA 50% Human Human +DTXSID00880763 Css NA 1.914 mg/L 3compartmentss NA 95% Human Human +DTXSID00880763 Css NA 0.1962 mg/L PBTK NA 50% Human Human +DTXSID00880763 Css NA 1.284 mg/L PBTK NA 95% Human Human +DTXSID00880763 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880763 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880763 Vd NA 1.658 L/kg 1compartment NA NA Rat Human +DTXSID00880763 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00880763 TK.Half.Life NA 1.945 hours 1compartment NA NA Rat Human +DTXSID00880763 Css NA 0.03571 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880763 Css NA 0.1983 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880763 Css NA 0.02459 mg/L PBTK NA 50% Rat Human +DTXSID00880763 Css NA 0.1297 mg/L PBTK NA 95% Rat Human +DTXSID00880849 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880849 Fup 0.0303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880849 Vd NA 3.101 L/kg 1compartment NA NA Human Human +DTXSID00880849 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID00880849 TK.Half.Life NA 76.39 hours 1compartment NA NA Human Human +DTXSID00880849 Css NA 2.942 mg/L 3compartmentss NA 50% Human Human +DTXSID00880849 Css NA 19.33 mg/L 3compartmentss NA 95% Human Human +DTXSID00880849 Css NA 2.037 mg/L PBTK NA 50% Human Human +DTXSID00880849 Css NA 13.1 mg/L PBTK NA 95% Human Human +DTXSID00880849 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880849 Fup 0.0303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880849 Vd NA 2.323 L/kg 1compartment NA NA Rat Human +DTXSID00880849 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID00880849 TK.Half.Life NA 10.63 hours 1compartment NA NA Rat Human +DTXSID00880849 Css NA 0.3754 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880849 Css NA 2.168 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880849 Css NA 0.258 mg/L PBTK NA 50% Rat Human +DTXSID00880849 Css NA 1.438 mg/L PBTK NA 95% Rat Human +DTXSID00880884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880884 Fup 0.017 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880884 Vd NA 2.461 L/kg 1compartment NA NA Human Human +DTXSID00880884 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID00880884 TK.Half.Life NA 32.77 hours 1compartment NA NA Human Human +DTXSID00880884 Css NA 1.874 mg/L 3compartmentss NA 50% Human Human +DTXSID00880884 Css NA 14.2 mg/L 3compartmentss NA 95% Human Human +DTXSID00880884 Css NA 1.232 mg/L PBTK NA 50% Human Human +DTXSID00880884 Css NA 9.131 mg/L PBTK NA 95% Human Human +DTXSID00880884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880884 Fup 0.017 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880884 Vd NA 1.834 L/kg 1compartment NA NA Rat Human +DTXSID00880884 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID00880884 TK.Half.Life NA 8.287 hours 1compartment NA NA Rat Human +DTXSID00880884 Css NA 0.2422 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880884 Css NA 1.511 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880884 Css NA 0.1567 mg/L PBTK NA 50% Rat Human +DTXSID00880884 Css NA 0.9429 mg/L PBTK NA 95% Rat Human +DTXSID00880900 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880900 Fup 0.033 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880900 Vd NA 6.162 L/kg 1compartment NA NA Human Human +DTXSID00880900 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID00880900 TK.Half.Life NA 51.96 hours 1compartment NA NA Human Human +DTXSID00880900 Css NA 0.865 mg/L 3compartmentss NA 50% Human Human +DTXSID00880900 Css NA 6.805 mg/L 3compartmentss NA 95% Human Human +DTXSID00880900 Css NA 0.7772 mg/L PBTK NA 50% Human Human +DTXSID00880900 Css NA 5.351 mg/L PBTK NA 95% Human Human +DTXSID00880900 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880900 Fup 0.033 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880900 Vd NA 4.772 L/kg 1compartment NA NA Rat Human +DTXSID00880900 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID00880900 TK.Half.Life NA 14.28 hours 1compartment NA NA Rat Human +DTXSID00880900 Css NA 0.108 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880900 Css NA 0.7083 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880900 Css NA 0.09837 mg/L PBTK NA 50% Rat Human +DTXSID00880900 Css NA 0.5607 mg/L PBTK NA 95% Rat Human +DTXSID00880905 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880905 Fup 0.0103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880905 Vd NA 2.095 L/kg 1compartment NA NA Human Human +DTXSID00880905 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID00880905 TK.Half.Life NA 32.79 hours 1compartment NA NA Human Human +DTXSID00880905 Css NA 2.352 mg/L 3compartmentss NA 50% Human Human +DTXSID00880905 Css NA 19.72 mg/L 3compartmentss NA 95% Human Human +DTXSID00880905 Css NA 1.514 mg/L PBTK NA 50% Human Human +DTXSID00880905 Css NA 12.05 mg/L PBTK NA 95% Human Human +DTXSID00880905 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880905 Fup 0.0103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880905 Vd NA 1.554 L/kg 1compartment NA NA Rat Human +DTXSID00880905 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID00880905 TK.Half.Life NA 10.06 hours 1compartment NA NA Rat Human +DTXSID00880905 Css NA 0.3077 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880905 Css NA 2.112 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880905 Css NA 0.1925 mg/L PBTK NA 50% Rat Human +DTXSID00880905 Css NA 1.287 mg/L PBTK NA 95% Rat Human +DTXSID00880920 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880920 Fup 0.818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00880920 Vd NA 0.5692 L/kg 1compartment NA NA Human Human +DTXSID00880920 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00880920 TK.Half.Life NA 4.507 hours 1compartment NA NA Human Human +DTXSID00880920 Css NA 1.018 mg/L 3compartmentss NA 50% Human Human +DTXSID00880920 Css NA 5.775 mg/L 3compartmentss NA 95% Human Human +DTXSID00880920 Css NA 0.7837 mg/L PBTK NA 50% Human Human +DTXSID00880920 Css NA 3.641 mg/L PBTK NA 95% Human Human +DTXSID00880920 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880920 Fup 0.818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00880920 Vd NA 0.5874 L/kg 1compartment NA NA Rat Human +DTXSID00880920 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00880920 TK.Half.Life NA 1.584 hours 1compartment NA NA Rat Human +DTXSID00880920 Css NA 0.06061 mg/L 3compartmentss NA 50% Rat Human +DTXSID00880920 Css NA 0.3482 mg/L 3compartmentss NA 95% Rat Human +DTXSID00880920 Css NA 0.04645 mg/L PBTK NA 50% Rat Human +DTXSID00880920 Css NA 0.2103 mg/L PBTK NA 95% Rat Human +DTXSID00881210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00881210 Fup 0.0398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00881210 Vd NA 2.812 L/kg 1compartment NA NA Human Human +DTXSID00881210 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID00881210 TK.Half.Life NA 31.27 hours 1compartment NA NA Human Human +DTXSID00881210 Css NA 1.408 mg/L 3compartmentss NA 50% Human Human +DTXSID00881210 Css NA 9.712 mg/L 3compartmentss NA 95% Human Human +DTXSID00881210 Css NA 0.9548 mg/L PBTK NA 50% Human Human +DTXSID00881210 Css NA 6.28 mg/L PBTK NA 95% Human Human +DTXSID00881210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00881210 Fup 0.0398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00881210 Vd NA 2.106 L/kg 1compartment NA NA Rat Human +DTXSID00881210 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID00881210 TK.Half.Life NA 6.189 hours 1compartment NA NA Rat Human +DTXSID00881210 Css NA 0.1819 mg/L 3compartmentss NA 50% Rat Human +DTXSID00881210 Css NA 1.027 mg/L 3compartmentss NA 95% Rat Human +DTXSID00881210 Css NA 0.1223 mg/L PBTK NA 50% Rat Human +DTXSID00881210 Css NA 0.673 mg/L PBTK NA 95% Rat Human +DTXSID00904978 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00904978 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00904978 Vd NA 0.7421 L/kg 1compartment NA NA Human Human DTXSID00904978 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID00904978 TK.Half.Life NA 1.656 hours 1compartment NA NA Human Human -DTXSID00904978 Css NA 0.2292 mg/L 3compartmentss NA 50% Human Human -DTXSID00904978 Css NA 1.823 mg/L 3compartmentss NA 95% Human Human -DTXSID00904978 Css NA 0.1511 mg/L PBTK NA 50% Human Human -DTXSID00904978 Css NA 1.126 mg/L PBTK NA 95% Human Human -DTXSID00904978 Clint NA 17.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID00904978 Fup NA 0.1463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID00904978 Vd NA 0.6115 L/kg 1compartment NA NA Rat Human +DTXSID00904978 TK.Half.Life NA 8.552 hours 1compartment NA NA Human Human +DTXSID00904978 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human +DTXSID00904978 Css NA 7.522 mg/L 3compartmentss NA 95% Human Human +DTXSID00904978 Css NA 0.8808 mg/L PBTK NA 50% Human Human +DTXSID00904978 Css NA 4.721 mg/L PBTK NA 95% Human Human +DTXSID00904978 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00904978 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00904978 Vd NA 0.7361 L/kg 1compartment NA NA Rat Human DTXSID00904978 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID00904978 TK.Half.Life NA 0.8024 hours 1compartment NA NA Rat Human -DTXSID00904978 Css NA 0.1275 mg/L 3compartmentss NA 50% Rat Human -DTXSID00904978 Css NA 0.7362 mg/L 3compartmentss NA 95% Rat Human -DTXSID00904978 Css NA 0.0792 mg/L PBTK NA 50% Rat Human -DTXSID00904978 Css NA 0.4274 mg/L PBTK NA 95% Rat Human -DTXSID101017364 Clint NA 2.544 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID101017364 Fup NA 0.3453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID101017364 Vd NA 4.584 L/kg 1compartment NA NA Human Human -DTXSID101017364 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID101017364 TK.Half.Life NA 16.02 hours 1compartment NA NA Human Human -DTXSID101017364 Css NA 0.2026 mg/L 3compartmentss NA 50% Human Human -DTXSID101017364 Css NA 1.407 mg/L 3compartmentss NA 95% Human Human -DTXSID101017364 Css NA 0.28 mg/L PBTK NA 50% Human Human -DTXSID101017364 Css NA 1.368 mg/L PBTK NA 95% Human Human -DTXSID101017364 Clint NA 2.544 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID101017364 Fup NA 0.3453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID101017364 Vd NA 4.632 L/kg 1compartment NA NA Rat Human +DTXSID00904978 TK.Half.Life NA 2.873 hours 1compartment NA NA Rat Human +DTXSID00904978 Css NA 0.02877 mg/L 3compartmentss NA 50% Rat Human +DTXSID00904978 Css NA 0.2305 mg/L 3compartmentss NA 95% Rat Human +DTXSID00904978 Css NA 0.02254 mg/L PBTK NA 50% Rat Human +DTXSID00904978 Css NA 0.1421 mg/L PBTK NA 95% Rat Human +DTXSID00905081 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00905081 Fup 0.825 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00905081 Vd NA 0.6453 L/kg 1compartment NA NA Human Human +DTXSID00905081 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00905081 TK.Half.Life NA 5.059 hours 1compartment NA NA Human Human +DTXSID00905081 Css NA 0.9725 mg/L 3compartmentss NA 50% Human Human +DTXSID00905081 Css NA 5.655 mg/L 3compartmentss NA 95% Human Human +DTXSID00905081 Css NA 0.7772 mg/L PBTK NA 50% Human Human +DTXSID00905081 Css NA 3.619 mg/L PBTK NA 95% Human Human +DTXSID00905081 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00905081 Fup 0.825 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00905081 Vd NA 0.6845 L/kg 1compartment NA NA Rat Human +DTXSID00905081 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00905081 TK.Half.Life NA 1.829 hours 1compartment NA NA Rat Human +DTXSID00905081 Css NA 0.05798 mg/L 3compartmentss NA 50% Rat Human +DTXSID00905081 Css NA 0.3325 mg/L 3compartmentss NA 95% Rat Human +DTXSID00905081 Css NA 0.04651 mg/L PBTK NA 50% Rat Human +DTXSID00905081 Css NA 0.2041 mg/L PBTK NA 95% Rat Human +DTXSID00951523 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00951523 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID00951523 Vd NA 0.6705 L/kg 1compartment NA NA Human Human +DTXSID00951523 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00951523 TK.Half.Life NA 5.424 hours 1compartment NA NA Human Human +DTXSID00951523 Css NA 0.539 mg/L 3compartmentss NA 50% Human Human +DTXSID00951523 Css NA 3.307 mg/L 3compartmentss NA 95% Human Human +DTXSID00951523 Css NA 0.4475 mg/L PBTK NA 50% Human Human +DTXSID00951523 Css NA 2.131 mg/L PBTK NA 95% Human Human +DTXSID00951523 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00951523 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID00951523 Vd NA 0.6855 L/kg 1compartment NA NA Rat Human +DTXSID00951523 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00951523 TK.Half.Life NA 1.889 hours 1compartment NA NA Rat Human +DTXSID00951523 Css NA 0.002777 mg/L 3compartmentss NA 50% Rat Human +DTXSID00951523 Css NA 0.01794 mg/L 3compartmentss NA 95% Rat Human +DTXSID00951523 Css NA 0.002232 mg/L PBTK NA 50% Rat Human +DTXSID00951523 Css NA 0.01122 mg/L PBTK NA 95% Rat Human +DTXSID00953320 Clint 27.54 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00953320 Fup 0.0294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00953320 Vd NA 2.843 L/kg 1compartment NA NA Human Human +DTXSID00953320 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID00953320 TK.Half.Life NA 30.89 hours 1compartment NA NA Human Human +DTXSID00953320 Css NA 1.198 mg/L 3compartmentss NA 50% Human Human +DTXSID00953320 Css NA 8.754 mg/L 3compartmentss NA 95% Human Human +DTXSID00953320 Css NA 0.8201 mg/L PBTK NA 50% Human Human +DTXSID00953320 Css NA 5.681 mg/L PBTK NA 95% Human Human +DTXSID00953320 Clint 27.54 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00953320 Fup 0.0294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00953320 Vd NA 2.128 L/kg 1compartment NA NA Rat Human +DTXSID00953320 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID00953320 TK.Half.Life NA 5.96 hours 1compartment NA NA Rat Human +DTXSID00953320 Css NA 0.06109 mg/L 3compartmentss NA 50% Rat Human +DTXSID00953320 Css NA 0.4277 mg/L 3compartmentss NA 95% Rat Human +DTXSID00953320 Css NA 0.04049 mg/L PBTK NA 50% Rat Human +DTXSID00953320 Css NA 0.2697 mg/L PBTK NA 95% Rat Human +DTXSID00955107 Clint 10.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00955107 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID00955107 Vd NA 1.995 L/kg 1compartment NA NA Human Human +DTXSID00955107 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID00955107 TK.Half.Life NA 3.705 hours 1compartment NA NA Human Human +DTXSID00955107 Css NA 0.1248 mg/L 3compartmentss NA 50% Human Human +DTXSID00955107 Css NA 0.9023 mg/L 3compartmentss NA 95% Human Human +DTXSID00955107 Css NA 0.1099 mg/L PBTK NA 50% Human Human +DTXSID00955107 Css NA 0.6773 mg/L PBTK NA 95% Human Human +DTXSID00955107 Clint 10.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00955107 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID00955107 Vd NA 1.984 L/kg 1compartment NA NA Rat Human +DTXSID00955107 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID00955107 TK.Half.Life NA 2.114 hours 1compartment NA NA Rat Human +DTXSID00955107 Css NA 0.01495 mg/L 3compartmentss NA 50% Rat Human +DTXSID00955107 Css NA 0.07986 mg/L 3compartmentss NA 95% Rat Human +DTXSID00955107 Css NA 0.01344 mg/L PBTK NA 50% Rat Human +DTXSID00955107 Css NA 0.05969 mg/L PBTK NA 95% Rat Human +DTXSID101017364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID101017364 Fup 0.334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID101017364 Vd NA 4.811 L/kg 1compartment NA NA Human Human +DTXSID101017364 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID101017364 TK.Half.Life NA 3.892 hours 1compartment NA NA Human Human +DTXSID101017364 Css NA 0.02658 mg/L 3compartmentss NA 50% Human Human +DTXSID101017364 Css NA 0.254 mg/L 3compartmentss NA 95% Human Human +DTXSID101017364 Css NA 0.03696 mg/L PBTK NA 50% Human Human +DTXSID101017364 Css NA 0.264 mg/L PBTK NA 95% Human Human +DTXSID101017364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID101017364 Fup 0.334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID101017364 Vd NA 4.842 L/kg 1compartment NA NA Rat Human DTXSID101017364 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID101017364 TK.Half.Life NA 8.718 hours 1compartment NA NA Rat Human -DTXSID101017364 Css NA 0.09425 mg/L 3compartmentss NA 50% Rat Human -DTXSID101017364 Css NA 0.4979 mg/L 3compartmentss NA 95% Rat Human -DTXSID101017364 Css NA 0.1306 mg/L PBTK NA 50% Rat Human -DTXSID101017364 Css NA 0.4467 mg/L PBTK NA 95% Rat Human +DTXSID101017364 TK.Half.Life NA 2.062 hours 1compartment NA NA Rat Human +DTXSID101017364 Css NA 0.00325 mg/L 3compartmentss NA 50% Rat Human +DTXSID101017364 Css NA 0.02347 mg/L 3compartmentss NA 95% Rat Human +DTXSID101017364 Css NA 0.004734 mg/L PBTK NA 50% Rat Human +DTXSID101017364 Css NA 0.02552 mg/L PBTK NA 95% Rat Human +DTXSID101021648 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID101021648 Fup 0.29 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID101021648 Vd NA 0.5945 L/kg 1compartment NA NA Human Human +DTXSID101021648 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID101021648 TK.Half.Life NA 3.362 hours 1compartment NA NA Human Human +DTXSID101021648 Css NA 0.5326 mg/L 3compartmentss NA 50% Human Human +DTXSID101021648 Css NA 2.675 mg/L 3compartmentss NA 95% Human Human +DTXSID101021648 Css NA 0.3792 mg/L PBTK NA 50% Human Human +DTXSID101021648 Css NA 1.702 mg/L PBTK NA 95% Human Human +DTXSID101021648 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID101021648 Fup 0.29 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID101021648 Vd NA 0.5655 L/kg 1compartment NA NA Rat Human +DTXSID101021648 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID101021648 TK.Half.Life NA 1.716 hours 1compartment NA NA Rat Human +DTXSID101021648 Css NA 0.02074 mg/L 3compartmentss NA 50% Rat Human +DTXSID101021648 Css NA 0.1328 mg/L 3compartmentss NA 95% Rat Human +DTXSID101021648 Css NA 0.0145 mg/L PBTK NA 50% Rat Human +DTXSID101021648 Css NA 0.08281 mg/L PBTK NA 95% Rat Human +DTXSID10110043 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10110043 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10110043 Vd NA 0.7638 L/kg 1compartment NA NA Human Human +DTXSID10110043 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10110043 TK.Half.Life NA 1.615 hours 1compartment NA NA Human Human +DTXSID10110043 Css NA 0.1387 mg/L 3compartmentss NA 50% Human Human +DTXSID10110043 Css NA 0.9776 mg/L 3compartmentss NA 95% Human Human +DTXSID10110043 Css NA 0.1132 mg/L PBTK NA 50% Human Human +DTXSID10110043 Css NA 0.6988 mg/L PBTK NA 95% Human Human +DTXSID10110043 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10110043 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10110043 Vd NA 0.7646 L/kg 1compartment NA NA Rat Human +DTXSID10110043 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10110043 TK.Half.Life NA 0.9206 hours 1compartment NA NA Rat Human +DTXSID10110043 Css NA 0.006024 mg/L 3compartmentss NA 50% Rat Human +DTXSID10110043 Css NA 0.04617 mg/L 3compartmentss NA 95% Rat Human +DTXSID10110043 Css NA 0.004995 mg/L PBTK NA 50% Rat Human +DTXSID10110043 Css NA 0.03204 mg/L PBTK NA 95% Rat Human +DTXSID101100630 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID101100630 Fup 0.0447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID101100630 Vd NA 2.517 L/kg 1compartment NA NA Human Human +DTXSID101100630 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID101100630 TK.Half.Life NA 8.988 hours 1compartment NA NA Human Human +DTXSID101100630 Css NA 0.397 mg/L 3compartmentss NA 50% Human Human +DTXSID101100630 Css NA 3.131 mg/L 3compartmentss NA 95% Human Human +DTXSID101100630 Css NA 0.2894 mg/L PBTK NA 50% Human Human +DTXSID101100630 Css NA 2.1 mg/L PBTK NA 95% Human Human +DTXSID101100630 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID101100630 Fup 0.0447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID101100630 Vd NA 2.105 L/kg 1compartment NA NA Rat Human +DTXSID101100630 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID101100630 TK.Half.Life NA 3.44 hours 1compartment NA NA Rat Human +DTXSID101100630 Css NA 0.05127 mg/L 3compartmentss NA 50% Rat Human +DTXSID101100630 Css NA 0.3281 mg/L 3compartmentss NA 95% Rat Human +DTXSID101100630 Css NA 0.03698 mg/L PBTK NA 50% Rat Human +DTXSID101100630 Css NA 0.2186 mg/L PBTK NA 95% Rat Human +DTXSID101111653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID101111653 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID101111653 Vd NA 0.8691 L/kg 1compartment NA NA Human Human +DTXSID101111653 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID101111653 TK.Half.Life NA 1.44 hours 1compartment NA NA Human Human +DTXSID101111653 Css NA 0.1082 mg/L 3compartmentss NA 50% Human Human +DTXSID101111653 Css NA 0.7563 mg/L 3compartmentss NA 95% Human Human +DTXSID101111653 Css NA 0.07476 mg/L PBTK NA 50% Human Human +DTXSID101111653 Css NA 0.489 mg/L PBTK NA 95% Human Human +DTXSID101111653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID101111653 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID101111653 Vd NA 0.7334 L/kg 1compartment NA NA Rat Human +DTXSID101111653 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID101111653 TK.Half.Life NA 0.6551 hours 1compartment NA NA Rat Human +DTXSID101111653 Css NA 0.01354 mg/L 3compartmentss NA 50% Rat Human +DTXSID101111653 Css NA 0.07336 mg/L 3compartmentss NA 95% Rat Human +DTXSID101111653 Css NA 0.009326 mg/L PBTK NA 50% Rat Human +DTXSID101111653 Css NA 0.04684 mg/L PBTK NA 95% Rat Human +DTXSID10146483 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10146483 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10146483 Vd NA 0.7809 L/kg 1compartment NA NA Human Human +DTXSID10146483 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10146483 TK.Half.Life NA 1.425 hours 1compartment NA NA Human Human +DTXSID10146483 Css NA 0.1322 mg/L 3compartmentss NA 50% Human Human +DTXSID10146483 Css NA 0.9159 mg/L 3compartmentss NA 95% Human Human +DTXSID10146483 Css NA 0.08956 mg/L PBTK NA 50% Human Human +DTXSID10146483 Css NA 0.5893 mg/L PBTK NA 95% Human Human +DTXSID10146483 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10146483 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10146483 Vd NA 0.6595 L/kg 1compartment NA NA Rat Human +DTXSID10146483 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10146483 TK.Half.Life NA 0.6627 hours 1compartment NA NA Rat Human +DTXSID10146483 Css NA 0.01703 mg/L 3compartmentss NA 50% Rat Human +DTXSID10146483 Css NA 0.09145 mg/L 3compartmentss NA 95% Rat Human +DTXSID10146483 Css NA 0.01136 mg/L PBTK NA 50% Rat Human +DTXSID10146483 Css NA 0.05783 mg/L PBTK NA 95% Rat Human +DTXSID10150282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10150282 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10150282 Vd NA 0.6331 L/kg 1compartment NA NA Human Human +DTXSID10150282 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10150282 TK.Half.Life NA 2.092 hours 1compartment NA NA Human Human +DTXSID10150282 Css NA 0.351 mg/L 3compartmentss NA 50% Human Human +DTXSID10150282 Css NA 2.878 mg/L 3compartmentss NA 95% Human Human +DTXSID10150282 Css NA 0.2184 mg/L PBTK NA 50% Human Human +DTXSID10150282 Css NA 1.741 mg/L PBTK NA 95% Human Human +DTXSID10150282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10150282 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10150282 Vd NA 0.5322 L/kg 1compartment NA NA Rat Human +DTXSID10150282 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10150282 TK.Half.Life NA 1.053 hours 1compartment NA NA Rat Human +DTXSID10150282 Css NA 0.01748 mg/L 3compartmentss NA 50% Rat Human +DTXSID10150282 Css NA 0.1503 mg/L 3compartmentss NA 95% Rat Human +DTXSID10150282 Css NA 0.01048 mg/L PBTK NA 50% Rat Human +DTXSID10150282 Css NA 0.08729 mg/L PBTK NA 95% Rat Human +DTXSID10152862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10152862 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10152862 Vd NA 3.143 L/kg 1compartment NA NA Human Human +DTXSID10152862 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID10152862 TK.Half.Life NA 39.41 hours 1compartment NA NA Human Human +DTXSID10152862 Css NA 1.407 mg/L 3compartmentss NA 50% Human Human +DTXSID10152862 Css NA 9.405 mg/L 3compartmentss NA 95% Human Human +DTXSID10152862 Css NA 0.9828 mg/L PBTK NA 50% Human Human +DTXSID10152862 Css NA 6.368 mg/L PBTK NA 95% Human Human +DTXSID10152862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10152862 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10152862 Vd NA 2.366 L/kg 1compartment NA NA Rat Human +DTXSID10152862 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID10152862 TK.Half.Life NA 5.663 hours 1compartment NA NA Rat Human +DTXSID10152862 Css NA 0.1835 mg/L 3compartmentss NA 50% Rat Human +DTXSID10152862 Css NA 1.062 mg/L 3compartmentss NA 95% Rat Human +DTXSID10152862 Css NA 0.1272 mg/L PBTK NA 50% Rat Human +DTXSID10152862 Css NA 0.7014 mg/L PBTK NA 95% Rat Human +DTXSID10158107 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10158107 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10158107 Vd NA 3.239 L/kg 1compartment NA NA Human Human +DTXSID10158107 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID10158107 TK.Half.Life NA 24.39 hours 1compartment NA NA Human Human +DTXSID10158107 Css NA 0.628 mg/L 3compartmentss NA 50% Human Human +DTXSID10158107 Css NA 4.878 mg/L 3compartmentss NA 95% Human Human +DTXSID10158107 Css NA 0.7668 mg/L PBTK NA 50% Human Human +DTXSID10158107 Css NA 3.642 mg/L PBTK NA 95% Human Human +DTXSID10158107 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10158107 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10158107 Vd NA 3.293 L/kg 1compartment NA NA Rat Human +DTXSID10158107 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10158107 TK.Half.Life NA 8.445 hours 1compartment NA NA Rat Human +DTXSID10158107 Css NA 0.03571 mg/L 3compartmentss NA 50% Rat Human +DTXSID10158107 Css NA 0.2704 mg/L 3compartmentss NA 95% Rat Human +DTXSID10158107 Css NA 0.0452 mg/L PBTK NA 50% Rat Human +DTXSID10158107 Css NA 0.1955 mg/L PBTK NA 95% Rat Human +DTXSID10161474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10161474 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10161474 Vd NA 2.105 L/kg 1compartment NA NA Human Human +DTXSID10161474 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10161474 TK.Half.Life NA 3.747 hours 1compartment NA NA Human Human +DTXSID10161474 Css NA 0.1226 mg/L 3compartmentss NA 50% Human Human +DTXSID10161474 Css NA 0.8279 mg/L 3compartmentss NA 95% Human Human +DTXSID10161474 Css NA 0.09076 mg/L PBTK NA 50% Human Human +DTXSID10161474 Css NA 0.5729 mg/L PBTK NA 95% Human Human +DTXSID10161474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10161474 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10161474 Vd NA 0.3423 L/kg 1compartment NA NA Rat Human +DTXSID10161474 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10161474 TK.Half.Life NA 3.943 hours 1compartment NA NA Rat Human +DTXSID10161474 Css NA 0.4144 mg/L 3compartmentss NA 50% Rat Human +DTXSID10161474 Css NA 3.262 mg/L 3compartmentss NA 95% Rat Human +DTXSID10161474 Css NA 0.2355 mg/L PBTK NA 50% Rat Human +DTXSID10161474 Css NA 1.838 mg/L PBTK NA 95% Rat Human +DTXSID10165351 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10165351 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10165351 Vd NA 0.1878 L/kg 1compartment NA NA Human Human +DTXSID10165351 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID10165351 TK.Half.Life NA 10.7 hours 1compartment NA NA Human Human +DTXSID10165351 Css NA 5.634 mg/L 3compartmentss NA 50% Human Human +DTXSID10165351 Css NA 50.26 mg/L 3compartmentss NA 95% Human Human +DTXSID10165351 Css NA 3.299 mg/L PBTK NA 50% Human Human +DTXSID10165351 Css NA 29.5 mg/L PBTK NA 95% Human Human +DTXSID10165351 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10165351 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10165351 Vd NA 0.1797 L/kg 1compartment NA NA Rat Human +DTXSID10165351 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10165351 TK.Half.Life NA 6.545 hours 1compartment NA NA Rat Human +DTXSID10165351 Css NA 0.06041 mg/L 3compartmentss NA 50% Rat Human +DTXSID10165351 Css NA 0.4795 mg/L 3compartmentss NA 95% Rat Human +DTXSID10165351 Css NA 0.03296 mg/L PBTK NA 50% Rat Human +DTXSID10165351 Css NA 0.2598 mg/L PBTK NA 95% Rat Human +DTXSID10173436 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10173436 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10173436 Vd NA 2.248 L/kg 1compartment NA NA Human Human +DTXSID10173436 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10173436 TK.Half.Life NA 11.38 hours 1compartment NA NA Human Human +DTXSID10173436 Css NA 0.7296 mg/L 3compartmentss NA 50% Human Human +DTXSID10173436 Css NA 7.012 mg/L 3compartmentss NA 95% Human Human +DTXSID10173436 Css NA 0.4524 mg/L PBTK NA 50% Human Human +DTXSID10173436 Css NA 4.347 mg/L PBTK NA 95% Human Human +DTXSID10173436 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10173436 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10173436 Vd NA 1.73 L/kg 1compartment NA NA Rat Human +DTXSID10173436 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10173436 TK.Half.Life NA 5.432 hours 1compartment NA NA Rat Human +DTXSID10173436 Css NA 0.09314 mg/L 3compartmentss NA 50% Rat Human +DTXSID10173436 Css NA 0.7175 mg/L 3compartmentss NA 95% Rat Human +DTXSID10173436 Css NA 0.05979 mg/L PBTK NA 50% Rat Human +DTXSID10173436 Css NA 0.4608 mg/L PBTK NA 95% Rat Human +DTXSID10174443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10174443 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10174443 Vd NA 3.529 L/kg 1compartment NA NA Human Human +DTXSID10174443 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10174443 TK.Half.Life NA 5.55 hours 1compartment NA NA Human Human +DTXSID10174443 Css NA 0.0927 mg/L 3compartmentss NA 50% Human Human +DTXSID10174443 Css NA 0.8551 mg/L 3compartmentss NA 95% Human Human +DTXSID10174443 Css NA 0.0865 mg/L PBTK NA 50% Human Human +DTXSID10174443 Css NA 0.6691 mg/L PBTK NA 95% Human Human +DTXSID10174443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10174443 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10174443 Vd NA 3.287 L/kg 1compartment NA NA Rat Human +DTXSID10174443 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10174443 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human +DTXSID10174443 Css NA 0.0044 mg/L 3compartmentss NA 50% Rat Human +DTXSID10174443 Css NA 0.04462 mg/L 3compartmentss NA 95% Rat Human +DTXSID10174443 Css NA 0.004152 mg/L PBTK NA 50% Rat Human +DTXSID10174443 Css NA 0.03543 mg/L PBTK NA 95% Rat Human +DTXSID10175096 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10175096 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10175096 Vd NA 0.9783 L/kg 1compartment NA NA Human Human +DTXSID10175096 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10175096 TK.Half.Life NA 1.18 hours 1compartment NA NA Human Human +DTXSID10175096 Css NA 0.04117 mg/L 3compartmentss NA 50% Human Human +DTXSID10175096 Css NA 0.4157 mg/L 3compartmentss NA 95% Human Human +DTXSID10175096 Css NA 0.03699 mg/L PBTK NA 50% Human Human +DTXSID10175096 Css NA 0.3003 mg/L PBTK NA 95% Human Human +DTXSID10175096 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10175096 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10175096 Vd NA 0.9914 L/kg 1compartment NA NA Rat Human +DTXSID10175096 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10175096 TK.Half.Life NA 0.6436 hours 1compartment NA NA Rat Human +DTXSID10175096 Css NA 0.000351 mg/L 3compartmentss NA 50% Rat Human +DTXSID10175096 Css NA 0.003804 mg/L 3compartmentss NA 95% Rat Human +DTXSID10175096 Css NA 0.000315 mg/L PBTK NA 50% Rat Human +DTXSID10175096 Css NA 0.002556 mg/L PBTK NA 95% Rat Human +DTXSID10180160 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10180160 Fup 0.0539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10180160 Vd NA 1.074 L/kg 1compartment NA NA Human Human +DTXSID10180160 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10180160 TK.Half.Life NA 4.412 hours 1compartment NA NA Human Human +DTXSID10180160 Css NA 0.3522 mg/L 3compartmentss NA 50% Human Human +DTXSID10180160 Css NA 3.173 mg/L 3compartmentss NA 95% Human Human +DTXSID10180160 Css NA 0.229 mg/L PBTK NA 50% Human Human +DTXSID10180160 Css NA 1.935 mg/L PBTK NA 95% Human Human +DTXSID10180160 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10180160 Fup 0.0539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10180160 Vd NA 0.8281 L/kg 1compartment NA NA Rat Human +DTXSID10180160 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10180160 TK.Half.Life NA 1.927 hours 1compartment NA NA Rat Human +DTXSID10180160 Css NA 0.005016 mg/L 3compartmentss NA 50% Rat Human +DTXSID10180160 Css NA 0.04372 mg/L 3compartmentss NA 95% Rat Human +DTXSID10180160 Css NA 0.003076 mg/L PBTK NA 50% Rat Human +DTXSID10180160 Css NA 0.0255 mg/L PBTK NA 95% Rat Human +DTXSID10189315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10189315 Fup 0.042 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10189315 Vd NA 2.281 L/kg 1compartment NA NA Human Human +DTXSID10189315 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10189315 TK.Half.Life NA 11.21 hours 1compartment NA NA Human Human +DTXSID10189315 Css NA 0.62 mg/L 3compartmentss NA 50% Human Human +DTXSID10189315 Css NA 4.555 mg/L 3compartmentss NA 95% Human Human +DTXSID10189315 Css NA 0.425 mg/L PBTK NA 50% Human Human +DTXSID10189315 Css NA 2.97 mg/L PBTK NA 95% Human Human +DTXSID10189315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10189315 Fup 0.042 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10189315 Vd NA 1.823 L/kg 1compartment NA NA Rat Human +DTXSID10189315 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10189315 TK.Half.Life NA 3.993 hours 1compartment NA NA Rat Human +DTXSID10189315 Css NA 0.08053 mg/L 3compartmentss NA 50% Rat Human +DTXSID10189315 Css NA 0.4967 mg/L 3compartmentss NA 95% Rat Human +DTXSID10189315 Css NA 0.05436 mg/L PBTK NA 50% Rat Human +DTXSID10189315 Css NA 0.3098 mg/L PBTK NA 95% Rat Human +DTXSID10191973 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID10191973 Fup 0.862 NA NA Williamson 2020 NA Human Human +DTXSID10191973 Vd NA 2.449 L/kg 1compartment NA NA Human Human +DTXSID10191973 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10191973 TK.Half.Life NA 8.714 hours 1compartment NA NA Human Human +DTXSID10191973 Css NA 0.2719 mg/L 3compartmentss NA 50% Human Human +DTXSID10191973 Css NA 1.656 mg/L 3compartmentss NA 95% Human Human +DTXSID10191973 Css NA 0.2471 mg/L PBTK NA 50% Human Human +DTXSID10191973 Css NA 1.201 mg/L PBTK NA 95% Human Human +DTXSID10191973 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID10191973 Fup 0.862 NA NA Williamson 2020 NA Rat Human +DTXSID10191973 Vd NA 1.992 L/kg 1compartment NA NA Rat Human +DTXSID10191973 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10191973 TK.Half.Life NA 2.476 hours 1compartment NA NA Rat Human +DTXSID10191973 Css NA 0.007965 mg/L 3compartmentss NA 50% Rat Human +DTXSID10191973 Css NA 0.0599 mg/L 3compartmentss NA 95% Rat Human +DTXSID10191973 Css NA 0.007175 mg/L PBTK NA 50% Rat Human +DTXSID10191973 Css NA 0.04503 mg/L PBTK NA 95% Rat Human +DTXSID10193230 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10193230 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10193230 Vd NA 1.577 L/kg 1compartment NA NA Human Human +DTXSID10193230 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID10193230 TK.Half.Life NA 17.26 hours 1compartment NA NA Human Human +DTXSID10193230 Css NA 1.036 mg/L 3compartmentss NA 50% Human Human +DTXSID10193230 Css NA 8.116 mg/L 3compartmentss NA 95% Human Human +DTXSID10193230 Css NA 0.9654 mg/L PBTK NA 50% Human Human +DTXSID10193230 Css NA 5.364 mg/L PBTK NA 95% Human Human +DTXSID10193230 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10193230 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10193230 Vd NA 1.598 L/kg 1compartment NA NA Rat Human +DTXSID10193230 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10193230 TK.Half.Life NA 5.96 hours 1compartment NA NA Rat Human +DTXSID10193230 Css NA 0.06282 mg/L 3compartmentss NA 50% Rat Human +DTXSID10193230 Css NA 0.446 mg/L 3compartmentss NA 95% Rat Human +DTXSID10193230 Css NA 0.05868 mg/L PBTK NA 50% Rat Human +DTXSID10193230 Css NA 0.2842 mg/L PBTK NA 95% Rat Human DTXSID10198927 Clint 29 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID10198927 Fup 0.62 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID10198927 Vd NA 1.417 L/kg 1compartment NA NA Human Human DTXSID10198927 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID10198927 TK.Half.Life NA 1.192 hours 1compartment NA NA Human Human -DTXSID10198927 Css NA 0.0278 mg/L 3compartmentss NA 50% Human Human -DTXSID10198927 Css NA 0.2893 mg/L 3compartmentss NA 95% Human Human -DTXSID10198927 Css NA 0.02322 mg/L PBTK NA 50% Human Human -DTXSID10198927 Css NA 0.2008 mg/L PBTK NA 95% Human Human +DTXSID10198927 Css NA 0.02552 mg/L 3compartmentss NA 50% Human Human +DTXSID10198927 Css NA 0.2774 mg/L 3compartmentss NA 95% Human Human +DTXSID10198927 Css NA 0.02118 mg/L PBTK NA 50% Human Human +DTXSID10198927 Css NA 0.198 mg/L PBTK NA 95% Human Human DTXSID10198927 Clint 29 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID10198927 Fup 0.62 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID10198927 Vd NA 1.198 L/kg 1compartment NA NA Rat Human DTXSID10198927 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID10198927 TK.Half.Life NA 0.4709 hours 1compartment NA NA Rat Human -DTXSID10198927 Css NA 0.01438 mg/L 3compartmentss NA 50% Rat Human -DTXSID10198927 Css NA 0.1325 mg/L 3compartmentss NA 95% Rat Human -DTXSID10198927 Css NA 0.01179 mg/L PBTK NA 50% Rat Human -DTXSID10198927 Css NA 0.08717 mg/L PBTK NA 95% Rat Human -DTXSID1020015 Clint NA 1.545 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020015 Fup NA 0.7739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020015 Vd NA 1.477 L/kg 1compartment NA NA Human Human +DTXSID10198927 Css NA 0.003119 mg/L 3compartmentss NA 50% Rat Human +DTXSID10198927 Css NA 0.02872 mg/L 3compartmentss NA 95% Rat Human +DTXSID10198927 Css NA 0.002644 mg/L PBTK NA 50% Rat Human +DTXSID10198927 Css NA 0.01981 mg/L PBTK NA 95% Rat Human +DTXSID1020015 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020015 Fup 0.518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020015 Vd NA 0.9791 L/kg 1compartment NA NA Human Human DTXSID1020015 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020015 TK.Half.Life NA 4.308 hours 1compartment NA NA Human Human -DTXSID1020015 Css NA 0.2824 mg/L 3compartmentss NA 50% Human Human -DTXSID1020015 Css NA 1.957 mg/L 3compartmentss NA 95% Human Human -DTXSID1020015 Css NA 0.2563 mg/L PBTK NA 50% Human Human -DTXSID1020015 Css NA 1.336 mg/L PBTK NA 95% Human Human -DTXSID1020015 Clint NA 1.545 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020015 Fup NA 0.7739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020015 Vd NA 1.316 L/kg 1compartment NA NA Rat Human +DTXSID1020015 TK.Half.Life NA 1.64 hours 1compartment NA NA Human Human +DTXSID1020015 Css NA 0.1216 mg/L 3compartmentss NA 50% Human Human +DTXSID1020015 Css NA 0.9289 mg/L 3compartmentss NA 95% Human Human +DTXSID1020015 Css NA 0.0988 mg/L PBTK NA 50% Human Human +DTXSID1020015 Css NA 0.6372 mg/L PBTK NA 95% Human Human +DTXSID1020015 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020015 Fup 0.518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020015 Vd NA 0.9019 L/kg 1compartment NA NA Rat Human DTXSID1020015 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020015 TK.Half.Life NA 1.8 hours 1compartment NA NA Rat Human -DTXSID1020015 Css NA 0.1131 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020015 Css NA 0.7876 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020015 Css NA 0.1011 mg/L PBTK NA 50% Rat Human -DTXSID1020015 Css NA 0.4922 mg/L PBTK NA 95% Rat Human -DTXSID1020063 Clint NA 3.059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020063 Fup NA 0.7136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020063 Vd NA 1.357 L/kg 1compartment NA NA Human Human +DTXSID1020015 TK.Half.Life NA 0.8123 hours 1compartment NA NA Rat Human +DTXSID1020015 Css NA 0.014 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020015 Css NA 0.08943 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020015 Css NA 0.01142 mg/L PBTK NA 50% Rat Human +DTXSID1020015 Css NA 0.05886 mg/L PBTK NA 95% Rat Human +DTXSID1020063 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020063 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020063 Vd NA 0.7054 L/kg 1compartment NA NA Human Human DTXSID1020063 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020063 TK.Half.Life NA 2.754 hours 1compartment NA NA Human Human -DTXSID1020063 Css NA 0.177 mg/L 3compartmentss NA 50% Human Human -DTXSID1020063 Css NA 1.337 mg/L 3compartmentss NA 95% Human Human -DTXSID1020063 Css NA 0.1579 mg/L PBTK NA 50% Human Human -DTXSID1020063 Css NA 0.9312 mg/L PBTK NA 95% Human Human -DTXSID1020063 Clint NA 3.059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020063 Fup NA 0.7136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020063 Vd NA 1.218 L/kg 1compartment NA NA Rat Human +DTXSID1020063 TK.Half.Life NA 1.009 hours 1compartment NA NA Human Human +DTXSID1020063 Css NA 0.08172 mg/L 3compartmentss NA 50% Human Human +DTXSID1020063 Css NA 0.5946 mg/L 3compartmentss NA 95% Human Human +DTXSID1020063 Css NA 0.05755 mg/L PBTK NA 50% Human Human +DTXSID1020063 Css NA 0.3905 mg/L PBTK NA 95% Human Human +DTXSID1020063 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020063 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020063 Vd NA 0.6359 L/kg 1compartment NA NA Rat Human DTXSID1020063 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020063 TK.Half.Life NA 1.251 hours 1compartment NA NA Rat Human -DTXSID1020063 Css NA 0.0801 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020063 Css NA 0.5809 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020063 Css NA 0.06982 mg/L PBTK NA 50% Rat Human -DTXSID1020063 Css NA 0.365 mg/L PBTK NA 95% Rat Human +DTXSID1020063 TK.Half.Life NA 0.4871 hours 1compartment NA NA Rat Human +DTXSID1020063 Css NA 0.01031 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020063 Css NA 0.05623 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020063 Css NA 0.007176 mg/L PBTK NA 50% Rat Human +DTXSID1020063 Css NA 0.03705 mg/L PBTK NA 95% Rat Human DTXSID1020069 Clint 6.89 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1020069 Fup 0.00696 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1020069 Vd NA 1.265 L/kg 1compartment NA NA Human Human -DTXSID1020069 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID1020069 TK.Half.Life NA 71.93 hours 1compartment NA NA Human Human -DTXSID1020069 Css NA 9.408 mg/L 3compartmentss NA 50% Human Human -DTXSID1020069 Css NA 78.02 mg/L 3compartmentss NA 95% Human Human -DTXSID1020069 Css NA 5.788 mg/L PBTK NA 50% Human Human -DTXSID1020069 Css NA 46.64 mg/L PBTK NA 95% Human Human +DTXSID1020069 Vd NA 1.96 L/kg 1compartment NA NA Human Human +DTXSID1020069 Days.Css NA 20 Days PBTK NA NA Human Human +DTXSID1020069 TK.Half.Life NA 111.7 hours 1compartment NA NA Human Human +DTXSID1020069 Css NA 8.718 mg/L 3compartmentss NA 50% Human Human +DTXSID1020069 Css NA 64.99 mg/L 3compartmentss NA 95% Human Human +DTXSID1020069 Css NA 5.543 mg/L PBTK NA 50% Human Human +DTXSID1020069 Css NA 39.73 mg/L PBTK NA 95% Human Human DTXSID1020069 Clint 6.89 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1020069 Fup 0.00696 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1020069 Vd NA 0.93 L/kg 1compartment NA NA Rat Human -DTXSID1020069 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID1020069 TK.Half.Life NA 28.95 hours 1compartment NA NA Rat Human -DTXSID1020069 Css NA 5.11 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020069 Css NA 31.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020069 Css NA 2.924 mg/L PBTK NA 50% Rat Human -DTXSID1020069 Css NA 17.68 mg/L PBTK NA 95% Rat Human -DTXSID1020140 Clint NA 0.03393 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020140 Fup NA 0.1766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020140 Vd NA 0.3792 L/kg 1compartment NA NA Human Human -DTXSID1020140 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1020140 TK.Half.Life NA 13.16 hours 1compartment NA NA Human Human -DTXSID1020140 Css NA 4.26 mg/L 3compartmentss NA 50% Human Human -DTXSID1020140 Css NA 16.23 mg/L 3compartmentss NA 95% Human Human -DTXSID1020140 Css NA 2.838 mg/L PBTK NA 50% Human Human -DTXSID1020140 Css NA 9.924 mg/L PBTK NA 95% Human Human -DTXSID1020140 Clint NA 0.03393 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020140 Fup NA 0.1766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020140 Vd NA 0.376 L/kg 1compartment NA NA Rat Human +DTXSID1020069 Vd NA 1.45 L/kg 1compartment NA NA Rat Human +DTXSID1020069 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID1020069 TK.Half.Life NA 35.58 hours 1compartment NA NA Rat Human +DTXSID1020069 Css NA 1.11 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020069 Css NA 6.348 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020069 Css NA 0.6882 mg/L PBTK NA 50% Rat Human +DTXSID1020069 Css NA 3.769 mg/L PBTK NA 95% Rat Human +DTXSID1020140 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020140 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020140 Vd NA 0.4584 L/kg 1compartment NA NA Human Human +DTXSID1020140 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1020140 TK.Half.Life NA 1.051 hours 1compartment NA NA Human Human +DTXSID1020140 Css NA 0.1926 mg/L 3compartmentss NA 50% Human Human +DTXSID1020140 Css NA 1.224 mg/L 3compartmentss NA 95% Human Human +DTXSID1020140 Css NA 0.1376 mg/L PBTK NA 50% Human Human +DTXSID1020140 Css NA 0.8014 mg/L PBTK NA 95% Human Human +DTXSID1020140 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020140 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020140 Vd NA 0.4606 L/kg 1compartment NA NA Rat Human DTXSID1020140 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020140 TK.Half.Life NA 4.569 hours 1compartment NA NA Rat Human -DTXSID1020140 Css NA 1.248 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020140 Css NA 3.992 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020140 Css NA 0.7844 mg/L PBTK NA 50% Rat Human -DTXSID1020140 Css NA 2.278 mg/L PBTK NA 95% Rat Human +DTXSID1020140 TK.Half.Life NA 0.5975 hours 1compartment NA NA Rat Human +DTXSID1020140 Css NA 0.02294 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020140 Css NA 0.1078 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020140 Css NA 0.01629 mg/L PBTK NA 50% Rat Human +DTXSID1020140 Css NA 0.06825 mg/L PBTK NA 95% Rat Human DTXSID1020142 Clint 1.18 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID1020142 Fup 0.343 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID1020142 Vd NA 0.6022 L/kg 1compartment NA NA Human Human +DTXSID1020142 Vd NA 0.5981 L/kg 1compartment NA NA Human Human DTXSID1020142 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020142 TK.Half.Life NA 4.085 hours 1compartment NA NA Human Human -DTXSID1020142 Css NA 0.7272 mg/L 3compartmentss NA 50% Human Human -DTXSID1020142 Css NA 2.53 mg/L 3compartmentss NA 95% Human Human -DTXSID1020142 Css NA 0.5196 mg/L PBTK NA 50% Human Human -DTXSID1020142 Css NA 1.681 mg/L PBTK NA 95% Human Human +DTXSID1020142 TK.Half.Life NA 4.056 hours 1compartment NA NA Human Human +DTXSID1020142 Css NA 0.712 mg/L 3compartmentss NA 50% Human Human +DTXSID1020142 Css NA 2.443 mg/L 3compartmentss NA 95% Human Human +DTXSID1020142 Css NA 0.5043 mg/L PBTK NA 50% Human Human +DTXSID1020142 Css NA 1.632 mg/L PBTK NA 95% Human Human DTXSID1020142 Clint 1.18 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID1020142 Fup 0.343 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID1020142 Vd NA 0.5577 L/kg 1compartment NA NA Rat Human +DTXSID1020142 Vd NA 0.5537 L/kg 1compartment NA NA Rat Human DTXSID1020142 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020142 TK.Half.Life NA 1.881 hours 1compartment NA NA Rat Human -DTXSID1020142 Css NA 0.3024 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020142 Css NA 0.7513 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020142 Css NA 0.2067 mg/L PBTK NA 50% Rat Human -DTXSID1020142 Css NA 0.4665 mg/L PBTK NA 95% Rat Human -DTXSID1020144 Clint NA 7.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020144 Fup NA 0.1283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020144 Vd NA 0.9335 L/kg 1compartment NA NA Human Human +DTXSID1020142 TK.Half.Life NA 1.868 hours 1compartment NA NA Rat Human +DTXSID1020142 Css NA 0.0679 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020142 Css NA 0.1678 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020142 Css NA 0.04808 mg/L PBTK NA 50% Rat Human +DTXSID1020142 Css NA 0.108 mg/L PBTK NA 95% Rat Human +DTXSID1020144 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020144 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020144 Vd NA 0.8813 L/kg 1compartment NA NA Human Human DTXSID1020144 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020144 TK.Half.Life NA 4.426 hours 1compartment NA NA Human Human -DTXSID1020144 Css NA 0.6238 mg/L 3compartmentss NA 50% Human Human -DTXSID1020144 Css NA 4.388 mg/L 3compartmentss NA 95% Human Human -DTXSID1020144 Css NA 0.4108 mg/L PBTK NA 50% Human Human -DTXSID1020144 Css NA 2.71 mg/L PBTK NA 95% Human Human -DTXSID1020144 Clint NA 7.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020144 Fup NA 0.1283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020144 Vd NA 0.7494 L/kg 1compartment NA NA Rat Human +DTXSID1020144 TK.Half.Life NA 2.086 hours 1compartment NA NA Human Human +DTXSID1020144 Css NA 0.2374 mg/L 3compartmentss NA 50% Human Human +DTXSID1020144 Css NA 1.94 mg/L 3compartmentss NA 95% Human Human +DTXSID1020144 Css NA 0.1553 mg/L PBTK NA 50% Human Human +DTXSID1020144 Css NA 1.21 mg/L PBTK NA 95% Human Human +DTXSID1020144 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020144 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020144 Vd NA 0.7071 L/kg 1compartment NA NA Rat Human DTXSID1020144 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020144 TK.Half.Life NA 2.016 hours 1compartment NA NA Rat Human -DTXSID1020144 Css NA 0.3268 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020144 Css NA 1.653 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020144 Css NA 0.2028 mg/L PBTK NA 50% Rat Human -DTXSID1020144 Css NA 0.9537 mg/L PBTK NA 95% Rat Human -DTXSID1020146 Clint NA 35.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020146 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020146 Vd NA 2.749 L/kg 1compartment NA NA Human Human -DTXSID1020146 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1020146 TK.Half.Life NA 23.11 hours 1compartment NA NA Human Human -DTXSID1020146 Css NA 1.095 mg/L 3compartmentss NA 50% Human Human -DTXSID1020146 Css NA 7.226 mg/L 3compartmentss NA 95% Human Human -DTXSID1020146 Css NA 0.7382 mg/L PBTK NA 50% Human Human -DTXSID1020146 Css NA 4.687 mg/L PBTK NA 95% Human Human -DTXSID1020146 Clint NA 35.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020146 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020146 Vd NA 2.056 L/kg 1compartment NA NA Rat Human -DTXSID1020146 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1020146 TK.Half.Life NA 4.895 hours 1compartment NA NA Rat Human -DTXSID1020146 Css NA 0.616 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020146 Css NA 3.454 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020146 Css NA 0.3952 mg/L PBTK NA 50% Rat Human -DTXSID1020146 Css NA 2.174 mg/L PBTK NA 95% Rat Human -DTXSID1020190 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020190 Fup NA 0.1849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020190 Vd NA 0.3819 L/kg 1compartment NA NA Human Human +DTXSID1020144 TK.Half.Life NA 0.9368 hours 1compartment NA NA Rat Human +DTXSID1020144 Css NA 0.03064 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020144 Css NA 0.1957 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020144 Css NA 0.01956 mg/L PBTK NA 50% Rat Human +DTXSID1020144 Css NA 0.118 mg/L PBTK NA 95% Rat Human +DTXSID1020146 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020146 Fup 0.0178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020146 Vd NA 2.73 L/kg 1compartment NA NA Human Human +DTXSID1020146 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1020146 TK.Half.Life NA 41.96 hours 1compartment NA NA Human Human +DTXSID1020146 Css NA 2.054 mg/L 3compartmentss NA 50% Human Human +DTXSID1020146 Css NA 14.52 mg/L 3compartmentss NA 95% Human Human +DTXSID1020146 Css NA 1.379 mg/L PBTK NA 50% Human Human +DTXSID1020146 Css NA 9.397 mg/L PBTK NA 95% Human Human +DTXSID1020146 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020146 Fup 0.0178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020146 Vd NA 2.039 L/kg 1compartment NA NA Rat Human +DTXSID1020146 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1020146 TK.Half.Life NA 8.73 hours 1compartment NA NA Rat Human +DTXSID1020146 Css NA 0.2669 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020146 Css NA 1.554 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020146 Css NA 0.1764 mg/L PBTK NA 50% Rat Human +DTXSID1020146 Css NA 0.9868 mg/L PBTK NA 95% Rat Human +DTXSID1020190 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020190 Fup 0.0998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020190 Vd NA 0.2295 L/kg 1compartment NA NA Human Human DTXSID1020190 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1020190 TK.Half.Life NA 13.36 hours 1compartment NA NA Human Human -DTXSID1020190 Css NA 4.352 mg/L 3compartmentss NA 50% Human Human -DTXSID1020190 Css NA 16.02 mg/L 3compartmentss NA 95% Human Human -DTXSID1020190 Css NA 2.89 mg/L PBTK NA 50% Human Human -DTXSID1020190 Css NA 9.838 mg/L PBTK NA 95% Human Human -DTXSID1020190 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020190 Fup NA 0.1849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020190 Vd NA 0.385 L/kg 1compartment NA NA Rat Human +DTXSID1020190 TK.Half.Life NA 14.88 hours 1compartment NA NA Human Human +DTXSID1020190 Css NA 8.678 mg/L 3compartmentss NA 50% Human Human +DTXSID1020190 Css NA 40.87 mg/L 3compartmentss NA 95% Human Human +DTXSID1020190 Css NA 5.244 mg/L PBTK NA 50% Human Human +DTXSID1020190 Css NA 23.76 mg/L PBTK NA 95% Human Human +DTXSID1020190 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020190 Fup 0.0998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020190 Vd NA 0.2384 L/kg 1compartment NA NA Rat Human DTXSID1020190 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020190 TK.Half.Life NA 4.59 hours 1compartment NA NA Rat Human -DTXSID1020190 Css NA 1.214 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020190 Css NA 3.788 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020190 Css NA 0.7582 mg/L PBTK NA 50% Rat Human -DTXSID1020190 Css NA 2.159 mg/L PBTK NA 95% Rat Human -DTXSID1020194 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020194 Fup NA 0.5907 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020194 Vd NA 0.5424 L/kg 1compartment NA NA Human Human -DTXSID1020194 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020194 TK.Half.Life NA 5.94 hours 1compartment NA NA Human Human -DTXSID1020194 Css NA 1.315 mg/L 3compartmentss NA 50% Human Human -DTXSID1020194 Css NA 8.889 mg/L 3compartmentss NA 95% Human Human -DTXSID1020194 Css NA 1.001 mg/L PBTK NA 50% Human Human -DTXSID1020194 Css NA 5.545 mg/L PBTK NA 95% Human Human -DTXSID1020194 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020194 Fup NA 0.5907 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020194 Vd NA 0.5728 L/kg 1compartment NA NA Rat Human -DTXSID1020194 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020194 TK.Half.Life NA 2.138 hours 1compartment NA NA Rat Human -DTXSID1020194 Css NA 0.3464 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020194 Css NA 2.106 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020194 Css NA 0.2524 mg/L PBTK NA 50% Rat Human -DTXSID1020194 Css NA 1.219 mg/L PBTK NA 95% Rat Human +DTXSID1020190 TK.Half.Life NA 5.267 hours 1compartment NA NA Rat Human +DTXSID1020190 Css NA 0.1618 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020190 Css NA 1.089 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020190 Css NA 0.09328 mg/L PBTK NA 50% Rat Human +DTXSID1020190 Css NA 0.6139 mg/L PBTK NA 95% Rat Human DTXSID1020221 Clint 26.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1020221 Fup 0.1052 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1020221 Vd NA 3.345 L/kg 1compartment NA NA Human Human DTXSID1020221 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1020221 TK.Half.Life NA 9.693 hours 1compartment NA NA Human Human -DTXSID1020221 Css NA 0.2038 mg/L 3compartmentss NA 50% Human Human -DTXSID1020221 Css NA 1.584 mg/L 3compartmentss NA 95% Human Human -DTXSID1020221 Css NA 0.2416 mg/L PBTK NA 50% Human Human -DTXSID1020221 Css NA 1.543 mg/L PBTK NA 95% Human Human +DTXSID1020221 Css NA 0.1989 mg/L 3compartmentss NA 50% Human Human +DTXSID1020221 Css NA 1.52 mg/L 3compartmentss NA 95% Human Human +DTXSID1020221 Css NA 0.2346 mg/L PBTK NA 50% Human Human +DTXSID1020221 Css NA 1.524 mg/L PBTK NA 95% Human Human DTXSID1020221 Clint 26.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1020221 Fup 0.1052 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1020221 Vd NA 2.892 L/kg 1compartment NA NA Rat Human DTXSID1020221 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1020221 TK.Half.Life NA 3.162 hours 1compartment NA NA Rat Human -DTXSID1020221 Css NA 0.1083 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020221 Css NA 0.6774 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020221 Css NA 0.1283 mg/L PBTK NA 50% Rat Human -DTXSID1020221 Css NA 0.663 mg/L PBTK NA 95% Rat Human +DTXSID1020221 Css NA 0.02393 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020221 Css NA 0.1591 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020221 Css NA 0.02963 mg/L PBTK NA 50% Rat Human +DTXSID1020221 Css NA 0.1625 mg/L PBTK NA 95% Rat Human DTXSID1020223 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1020223 Fup NA 0.8104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020223 Vd NA 0.7796 L/kg 1compartment NA NA Human Human +DTXSID1020223 Vd NA 0.7908 L/kg 1compartment NA NA Human Human DTXSID1020223 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020223 TK.Half.Life NA 6.245 hours 1compartment NA NA Human Human -DTXSID1020223 Css NA 0.977 mg/L 3compartmentss NA 50% Human Human -DTXSID1020223 Css NA 5.584 mg/L 3compartmentss NA 95% Human Human -DTXSID1020223 Css NA 0.8098 mg/L PBTK NA 50% Human Human -DTXSID1020223 Css NA 3.635 mg/L PBTK NA 95% Human Human +DTXSID1020223 TK.Half.Life NA 6.336 hours 1compartment NA NA Human Human +DTXSID1020223 Css NA 0.8248 mg/L 3compartmentss NA 50% Human Human +DTXSID1020223 Css NA 4.91 mg/L 3compartmentss NA 95% Human Human +DTXSID1020223 Css NA 0.6904 mg/L PBTK NA 50% Human Human +DTXSID1020223 Css NA 3.199 mg/L PBTK NA 95% Human Human DTXSID1020223 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1020223 Fup NA 0.8104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020223 Vd NA 0.7985 L/kg 1compartment NA NA Rat Human +DTXSID1020223 Vd NA 0.8081 L/kg 1compartment NA NA Rat Human DTXSID1020223 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020223 TK.Half.Life NA 2.174 hours 1compartment NA NA Rat Human -DTXSID1020223 Css NA 0.2486 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020223 Css NA 1.514 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020223 Css NA 0.201 mg/L PBTK NA 50% Rat Human -DTXSID1020223 Css NA 0.9079 mg/L PBTK NA 95% Rat Human -DTXSID1020275 Clint NA 62.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020275 Fup NA 0.0534 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020275 Vd NA 2.697 L/kg 1compartment NA NA Human Human -DTXSID1020275 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020275 TK.Half.Life NA 9.093 hours 1compartment NA NA Human Human -DTXSID1020275 Css NA 0.3576 mg/L 3compartmentss NA 50% Human Human -DTXSID1020275 Css NA 2.393 mg/L 3compartmentss NA 95% Human Human -DTXSID1020275 Css NA 0.2438 mg/L PBTK NA 50% Human Human -DTXSID1020275 Css NA 1.541 mg/L PBTK NA 95% Human Human -DTXSID1020275 Clint NA 62.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020275 Fup NA 0.0534 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020275 Vd NA 2.022 L/kg 1compartment NA NA Rat Human -DTXSID1020275 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020275 TK.Half.Life NA 2.18 hours 1compartment NA NA Rat Human -DTXSID1020275 Css NA 0.201 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020275 Css NA 1.129 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020275 Css NA 0.1303 mg/L PBTK NA 50% Rat Human -DTXSID1020275 Css NA 0.7019 mg/L PBTK NA 95% Rat Human -DTXSID1020308 Clint NA 2.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020308 Fup NA 0.6419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020308 Vd NA 1.297 L/kg 1compartment NA NA Human Human +DTXSID1020223 TK.Half.Life NA 2.2 hours 1compartment NA NA Rat Human +DTXSID1020223 Css NA 0.01555 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020223 Css NA 0.1174 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020223 Css NA 0.0125 mg/L PBTK NA 50% Rat Human +DTXSID1020223 Css NA 0.076 mg/L PBTK NA 95% Rat Human +DTXSID1020275 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020275 Fup 0.0174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020275 Vd NA 2.114 L/kg 1compartment NA NA Human Human +DTXSID1020275 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1020275 TK.Half.Life NA 24.36 hours 1compartment NA NA Human Human +DTXSID1020275 Css NA 1.7 mg/L 3compartmentss NA 50% Human Human +DTXSID1020275 Css NA 13.99 mg/L 3compartmentss NA 95% Human Human +DTXSID1020275 Css NA 1.093 mg/L PBTK NA 50% Human Human +DTXSID1020275 Css NA 8.708 mg/L PBTK NA 95% Human Human +DTXSID1020275 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020275 Fup 0.0174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020275 Vd NA 1.571 L/kg 1compartment NA NA Rat Human +DTXSID1020275 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1020275 TK.Half.Life NA 7.428 hours 1compartment NA NA Rat Human +DTXSID1020275 Css NA 0.2212 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020275 Css NA 1.494 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020275 Css NA 0.1392 mg/L PBTK NA 50% Rat Human +DTXSID1020275 Css NA 0.9083 mg/L PBTK NA 95% Rat Human +DTXSID1020308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020308 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020308 Vd NA 0.9376 L/kg 1compartment NA NA Human Human DTXSID1020308 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020308 TK.Half.Life NA 3.212 hours 1compartment NA NA Human Human -DTXSID1020308 Css NA 0.2277 mg/L 3compartmentss NA 50% Human Human -DTXSID1020308 Css NA 1.868 mg/L 3compartmentss NA 95% Human Human -DTXSID1020308 Css NA 0.1956 mg/L PBTK NA 50% Human Human -DTXSID1020308 Css NA 1.245 mg/L PBTK NA 95% Human Human -DTXSID1020308 Clint NA 2.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020308 Fup NA 0.6419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020308 Vd NA 1.159 L/kg 1compartment NA NA Rat Human +DTXSID1020308 TK.Half.Life NA 1.076 hours 1compartment NA NA Human Human +DTXSID1020308 Css NA 0.05184 mg/L 3compartmentss NA 50% Human Human +DTXSID1020308 Css NA 0.3993 mg/L 3compartmentss NA 95% Human Human +DTXSID1020308 Css NA 0.03957 mg/L PBTK NA 50% Human Human +DTXSID1020308 Css NA 0.2746 mg/L PBTK NA 95% Human Human +DTXSID1020308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020308 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020308 Vd NA 0.8369 L/kg 1compartment NA NA Rat Human DTXSID1020308 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020308 TK.Half.Life NA 1.448 hours 1compartment NA NA Rat Human -DTXSID1020308 Css NA 0.09966 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020308 Css NA 0.7342 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020308 Css NA 0.08485 mg/L PBTK NA 50% Rat Human -DTXSID1020308 Css NA 0.4514 mg/L PBTK NA 95% Rat Human +DTXSID1020308 TK.Half.Life NA 0.4916 hours 1compartment NA NA Rat Human +DTXSID1020308 Css NA 0.006396 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020308 Css NA 0.03947 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020308 Css NA 0.004927 mg/L PBTK NA 50% Rat Human +DTXSID1020308 Css NA 0.02683 mg/L PBTK NA 95% Rat Human DTXSID1020350 Clint 19.53 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1020350 Fup 0.4043 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1020350 Vd NA 1.306 L/kg 1compartment NA NA Human Human DTXSID1020350 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1020350 TK.Half.Life NA 1.53 hours 1compartment NA NA Human Human -DTXSID1020350 Css NA 0.05936 mg/L 3compartmentss NA 50% Human Human -DTXSID1020350 Css NA 0.4467 mg/L 3compartmentss NA 95% Human Human -DTXSID1020350 Css NA 0.04703 mg/L PBTK NA 50% Human Human -DTXSID1020350 Css NA 0.3132 mg/L PBTK NA 95% Human Human +DTXSID1020350 Css NA 0.0559 mg/L 3compartmentss NA 50% Human Human +DTXSID1020350 Css NA 0.4504 mg/L 3compartmentss NA 95% Human Human +DTXSID1020350 Css NA 0.04408 mg/L PBTK NA 50% Human Human +DTXSID1020350 Css NA 0.3125 mg/L PBTK NA 95% Human Human DTXSID1020350 Clint 19.53 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1020350 Fup 0.4043 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1020350 Vd NA 1.106 L/kg 1compartment NA NA Rat Human DTXSID1020350 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1020350 TK.Half.Life NA 0.6466 hours 1compartment NA NA Rat Human -DTXSID1020350 Css NA 0.03159 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020350 Css NA 0.1884 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020350 Css NA 0.02424 mg/L PBTK NA 50% Rat Human -DTXSID1020350 Css NA 0.1266 mg/L PBTK NA 95% Rat Human -DTXSID1020352 Clint NA 0.01341 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020352 Fup NA 0.2013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020352 Vd NA 0.3075 L/kg 1compartment NA NA Human Human -DTXSID1020352 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1020352 TK.Half.Life NA 9.666 hours 1compartment NA NA Human Human -DTXSID1020352 Css NA 3.954 mg/L 3compartmentss NA 50% Human Human -DTXSID1020352 Css NA 14.15 mg/L 3compartmentss NA 95% Human Human -DTXSID1020352 Css NA 2.554 mg/L PBTK NA 50% Human Human -DTXSID1020352 Css NA 8.506 mg/L PBTK NA 95% Human Human -DTXSID1020352 Clint NA 0.01341 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020352 Fup NA 0.2013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020352 Vd NA 0.3087 L/kg 1compartment NA NA Rat Human +DTXSID1020350 Css NA 0.006905 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020350 Css NA 0.043 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020350 Css NA 0.005536 mg/L PBTK NA 50% Rat Human +DTXSID1020350 Css NA 0.03029 mg/L PBTK NA 95% Rat Human +DTXSID1020352 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020352 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020352 Vd NA 0.434 L/kg 1compartment NA NA Human Human +DTXSID1020352 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1020352 TK.Half.Life NA 0.5082 hours 1compartment NA NA Human Human +DTXSID1020352 Css NA 0.05254 mg/L 3compartmentss NA 50% Human Human +DTXSID1020352 Css NA 0.4221 mg/L 3compartmentss NA 95% Human Human +DTXSID1020352 Css NA 0.03735 mg/L PBTK NA 50% Human Human +DTXSID1020352 Css NA 0.2744 mg/L PBTK NA 95% Human Human +DTXSID1020352 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020352 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020352 Vd NA 0.4362 L/kg 1compartment NA NA Rat Human DTXSID1020352 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020352 TK.Half.Life NA 3.345 hours 1compartment NA NA Rat Human -DTXSID1020352 Css NA 1.115 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020352 Css NA 3.433 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020352 Css NA 0.6788 mg/L PBTK NA 50% Rat Human -DTXSID1020352 Css NA 1.936 mg/L PBTK NA 95% Rat Human +DTXSID1020352 TK.Half.Life NA 0.2632 hours 1compartment NA NA Rat Human +DTXSID1020352 Css NA 0.006521 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020352 Css NA 0.03973 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020352 Css NA 0.004604 mg/L PBTK NA 50% Rat Human +DTXSID1020352 Css NA 0.02548 mg/L PBTK NA 95% Rat Human DTXSID1020354 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1020354 Fup NA 0.8275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1020354 Vd NA 1.061 L/kg 1compartment NA NA Human Human DTXSID1020354 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1020354 TK.Half.Life NA 8.295 hours 1compartment NA NA Human Human -DTXSID1020354 Css NA 0.9154 mg/L 3compartmentss NA 50% Human Human -DTXSID1020354 Css NA 5.748 mg/L 3compartmentss NA 95% Human Human -DTXSID1020354 Css NA 0.8002 mg/L PBTK NA 50% Human Human -DTXSID1020354 Css NA 3.806 mg/L PBTK NA 95% Human Human +DTXSID1020354 Css NA 0.7775 mg/L 3compartmentss NA 50% Human Human +DTXSID1020354 Css NA 4.856 mg/L 3compartmentss NA 95% Human Human +DTXSID1020354 Css NA 0.6806 mg/L PBTK NA 50% Human Human +DTXSID1020354 Css NA 3.182 mg/L PBTK NA 95% Human Human DTXSID1020354 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1020354 Fup NA 0.8275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1020354 Vd NA 1.07 L/kg 1compartment NA NA Rat Human DTXSID1020354 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1020354 TK.Half.Life NA 2.851 hours 1compartment NA NA Rat Human -DTXSID1020354 Css NA 0.2338 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020354 Css NA 1.407 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020354 Css NA 0.1986 mg/L PBTK NA 50% Rat Human -DTXSID1020354 Css NA 0.8607 mg/L PBTK NA 95% Rat Human +DTXSID1020354 Css NA 0.01456 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020354 Css NA 0.1139 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020354 Css NA 0.01227 mg/L PBTK NA 50% Rat Human +DTXSID1020354 Css NA 0.0771 mg/L PBTK NA 95% Rat Human DTXSID1020358 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1020358 Fup NA 0.8334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020358 Vd NA 0.6556 L/kg 1compartment NA NA Human Human -DTXSID1020358 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020358 TK.Half.Life NA 5.089 hours 1compartment NA NA Human Human -DTXSID1020358 Css NA 0.992 mg/L 3compartmentss NA 50% Human Human -DTXSID1020358 Css NA 5.726 mg/L 3compartmentss NA 95% Human Human -DTXSID1020358 Css NA 0.7944 mg/L PBTK NA 50% Human Human -DTXSID1020358 Css NA 3.661 mg/L PBTK NA 95% Human Human +DTXSID1020358 Vd NA 1.549 L/kg 1compartment NA NA Human Human +DTXSID1020358 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1020358 TK.Half.Life NA 13.9 hours 1compartment NA NA Human Human +DTXSID1020358 Css NA 0.7732 mg/L 3compartmentss NA 50% Human Human +DTXSID1020358 Css NA 5.025 mg/L 3compartmentss NA 95% Human Human +DTXSID1020358 Css NA 0.7262 mg/L PBTK NA 50% Human Human +DTXSID1020358 Css NA 3.423 mg/L PBTK NA 95% Human Human DTXSID1020358 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1020358 Fup NA 0.8334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020358 Vd NA 0.6953 L/kg 1compartment NA NA Rat Human +DTXSID1020358 Vd NA 1.38 L/kg 1compartment NA NA Rat Human DTXSID1020358 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020358 TK.Half.Life NA 1.84 hours 1compartment NA NA Rat Human -DTXSID1020358 Css NA 0.2546 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020358 Css NA 1.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020358 Css NA 0.1983 mg/L PBTK NA 50% Rat Human -DTXSID1020358 Css NA 0.868 mg/L PBTK NA 95% Rat Human -DTXSID1020433 Clint NA 139.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020433 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020433 Vd NA 2.132 L/kg 1compartment NA NA Human Human +DTXSID1020358 TK.Half.Life NA 3.788 hours 1compartment NA NA Rat Human +DTXSID1020358 Css NA 0.01446 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020358 Css NA 0.1141 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020358 Css NA 0.01301 mg/L PBTK NA 50% Rat Human +DTXSID1020358 Css NA 0.08051 mg/L PBTK NA 95% Rat Human +DTXSID1020433 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020433 Fup 0.0408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020433 Vd NA 1.586 L/kg 1compartment NA NA Human Human DTXSID1020433 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020433 TK.Half.Life NA 3.51 hours 1compartment NA NA Human Human -DTXSID1020433 Css NA 0.1246 mg/L 3compartmentss NA 50% Human Human -DTXSID1020433 Css NA 1.001 mg/L 3compartmentss NA 95% Human Human -DTXSID1020433 Css NA 0.08231 mg/L PBTK NA 50% Human Human -DTXSID1020433 Css NA 0.6292 mg/L PBTK NA 95% Human Human -DTXSID1020433 Clint NA 139.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020433 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020433 Vd NA 1.596 L/kg 1compartment NA NA Rat Human +DTXSID1020433 TK.Half.Life NA 8.815 hours 1compartment NA NA Human Human +DTXSID1020433 Css NA 0.7974 mg/L 3compartmentss NA 50% Human Human +DTXSID1020433 Css NA 6.522 mg/L 3compartmentss NA 95% Human Human +DTXSID1020433 Css NA 0.5108 mg/L PBTK NA 50% Human Human +DTXSID1020433 Css NA 3.927 mg/L PBTK NA 95% Human Human +DTXSID1020433 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020433 Fup 0.0408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020433 Vd NA 1.187 L/kg 1compartment NA NA Rat Human DTXSID1020433 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020433 TK.Half.Life NA 1.119 hours 1compartment NA NA Rat Human -DTXSID1020433 Css NA 0.07132 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020433 Css NA 0.4393 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020433 Css NA 0.04442 mg/L PBTK NA 50% Rat Human -DTXSID1020433 Css NA 0.2678 mg/L PBTK NA 95% Rat Human -DTXSID1020439 Clint NA 8.824 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1020433 TK.Half.Life NA 3.312 hours 1compartment NA NA Rat Human +DTXSID1020433 Css NA 0.1036 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020433 Css NA 0.6898 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020433 Css NA 0.06417 mg/L PBTK NA 50% Rat Human +DTXSID1020433 Css NA 0.4104 mg/L PBTK NA 95% Rat Human +DTXSID1020439 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1020439 Fup 0.23 NA NA https://doi.org/10.1016/S0300-483X(02)00085-9 NA Human Human DTXSID1020439 Vd NA 2.386 L/kg 1compartment NA NA Human Human DTXSID1020439 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020439 TK.Half.Life NA 10.35 hours 1compartment NA NA Human Human -DTXSID1020439 Css NA 0.4364 mg/L 3compartmentss NA 50% Human Human -DTXSID1020439 Css NA 2.467 mg/L 3compartmentss NA 95% Human Human -DTXSID1020439 Css NA 0.3208 mg/L PBTK NA 50% Human Human -DTXSID1020439 Css NA 1.716 mg/L PBTK NA 95% Human Human -DTXSID1020439 Clint NA 8.824 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1020439 TK.Half.Life NA 5.398 hours 1compartment NA NA Human Human +DTXSID1020439 Css NA 0.1802 mg/L 3compartmentss NA 50% Human Human +DTXSID1020439 Css NA 1.149 mg/L 3compartmentss NA 95% Human Human +DTXSID1020439 Css NA 0.1306 mg/L PBTK NA 50% Human Human +DTXSID1020439 Css NA 0.8052 mg/L PBTK NA 95% Human Human +DTXSID1020439 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1020439 Fup 0.23 NA NA https://doi.org/10.1016/S0300-483X(02)00085-9 NA Rat Human DTXSID1020439 Vd NA 1.823 L/kg 1compartment NA NA Rat Human DTXSID1020439 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020439 TK.Half.Life NA 2.886 hours 1compartment NA NA Rat Human -DTXSID1020439 Css NA 0.2324 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020439 Css NA 0.9394 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020439 Css NA 0.1632 mg/L PBTK NA 50% Rat Human -DTXSID1020439 Css NA 0.6355 mg/L PBTK NA 95% Rat Human -DTXSID1020483 Clint NA 168.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020483 Fup NA 0.6151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020483 Vd NA 1.22 L/kg 1compartment NA NA Human Human -DTXSID1020483 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020483 TK.Half.Life NA 0.7801 hours 1compartment NA NA Human Human -DTXSID1020483 Css NA 0.004598 mg/L 3compartmentss NA 50% Human Human -DTXSID1020483 Css NA 0.05109 mg/L 3compartmentss NA 95% Human Human -DTXSID1020483 Css NA 0.003929 mg/L PBTK NA 50% Human Human -DTXSID1020483 Css NA 0.0363 mg/L PBTK NA 95% Human Human -DTXSID1020483 Clint NA 168.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020483 Fup NA 0.6151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020483 Vd NA 1.104 L/kg 1compartment NA NA Rat Human +DTXSID1020439 TK.Half.Life NA 1.588 hours 1compartment NA NA Rat Human +DTXSID1020439 Css NA 0.02255 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020439 Css NA 0.1117 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020439 Css NA 0.01641 mg/L PBTK NA 50% Rat Human +DTXSID1020439 Css NA 0.07848 mg/L PBTK NA 95% Rat Human +DTXSID10204698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10204698 Fup 0.682 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10204698 Vd NA 0.8905 L/kg 1compartment NA NA Human Human +DTXSID10204698 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10204698 TK.Half.Life NA 8.471 hours 1compartment NA NA Human Human +DTXSID10204698 Css NA 0.9318 mg/L 3compartmentss NA 50% Human Human +DTXSID10204698 Css NA 6.227 mg/L 3compartmentss NA 95% Human Human +DTXSID10204698 Css NA 0.7729 mg/L PBTK NA 50% Human Human +DTXSID10204698 Css NA 3.926 mg/L PBTK NA 95% Human Human +DTXSID10204698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10204698 Fup 0.682 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10204698 Vd NA 0.9021 L/kg 1compartment NA NA Rat Human +DTXSID10204698 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10204698 TK.Half.Life NA 2.92 hours 1compartment NA NA Rat Human +DTXSID10204698 Css NA 0.02399 mg/L 3compartmentss NA 50% Rat Human +DTXSID10204698 Css NA 0.194 mg/L 3compartmentss NA 95% Rat Human +DTXSID10204698 Css NA 0.01936 mg/L PBTK NA 50% Rat Human +DTXSID10204698 Css NA 0.1233 mg/L PBTK NA 95% Rat Human +DTXSID1020483 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020483 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020483 Vd NA 1.04 L/kg 1compartment NA NA Human Human +DTXSID1020483 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1020483 TK.Half.Life NA 17.91 hours 1compartment NA NA Human Human +DTXSID1020483 Css NA 1.777 mg/L 3compartmentss NA 50% Human Human +DTXSID1020483 Css NA 7.647 mg/L 3compartmentss NA 95% Human Human +DTXSID1020483 Css NA 1.402 mg/L PBTK NA 50% Human Human +DTXSID1020483 Css NA 5.056 mg/L PBTK NA 95% Human Human +DTXSID1020483 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020483 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020483 Vd NA 0.9215 L/kg 1compartment NA NA Rat Human DTXSID1020483 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020483 TK.Half.Life NA 0.3117 hours 1compartment NA NA Rat Human -DTXSID1020483 Css NA 0.002386 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020483 Css NA 0.0253 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020483 Css NA 0.002009 mg/L PBTK NA 50% Rat Human -DTXSID1020483 Css NA 0.01718 mg/L PBTK NA 95% Rat Human +DTXSID1020483 TK.Half.Life NA 5.119 hours 1compartment NA NA Rat Human +DTXSID1020483 Css NA 0.111 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020483 Css NA 0.4224 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020483 Css NA 0.087 mg/L PBTK NA 50% Rat Human +DTXSID1020483 Css NA 0.2671 mg/L PBTK NA 95% Rat Human DTXSID1020485 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1020485 Fup 0.201 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1020485 Vd NA 0.976 L/kg 1compartment NA NA Human Human -DTXSID1020485 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID1020485 TK.Half.Life NA 34.31 hours 1compartment NA NA Human Human -DTXSID1020485 Css NA 0.5983 mg/L 3compartmentss NA 50% Human Human -DTXSID1020485 Css NA 2.693 mg/L 3compartmentss NA 95% Human Human -DTXSID1020485 Css NA 0.4209 mg/L PBTK NA 50% Human Human -DTXSID1020485 Css NA 1.809 mg/L PBTK NA 95% Human Human +DTXSID1020485 Vd NA 1.067 L/kg 1compartment NA NA Human Human +DTXSID1020485 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID1020485 TK.Half.Life NA 38.42 hours 1compartment NA NA Human Human +DTXSID1020485 Css NA 0.5809 mg/L 3compartmentss NA 50% Human Human +DTXSID1020485 Css NA 2.633 mg/L 3compartmentss NA 95% Human Human +DTXSID1020485 Css NA 0.4142 mg/L PBTK NA 50% Human Human +DTXSID1020485 Css NA 1.776 mg/L PBTK NA 95% Human Human DTXSID1020485 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1020485 Fup 0.201 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1020485 Vd NA 0.8243 L/kg 1compartment NA NA Rat Human +DTXSID1020485 Vd NA 0.889 L/kg 1compartment NA NA Rat Human DTXSID1020485 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1020485 TK.Half.Life NA 9.239 hours 1compartment NA NA Rat Human -DTXSID1020485 Css NA 0.2889 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020485 Css NA 0.952 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020485 Css NA 0.196 mg/L PBTK NA 50% Rat Human -DTXSID1020485 Css NA 0.5934 mg/L PBTK NA 95% Rat Human +DTXSID1020485 TK.Half.Life NA 10.03 hours 1compartment NA NA Rat Human +DTXSID1020485 Css NA 0.06543 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020485 Css NA 0.2133 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020485 Css NA 0.0461 mg/L PBTK NA 50% Rat Human +DTXSID1020485 Css NA 0.139 mg/L PBTK NA 95% Rat Human DTXSID1020510 Clint 3.226 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID1020510 Fup NA 0.0212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020510 Vd NA 3.118 L/kg 1compartment NA NA Human Human -DTXSID1020510 Days.Css NA 141 Days PBTK NA NA Human Human -DTXSID1020510 TK.Half.Life NA 586.4 hours 1compartment NA NA Human Human -DTXSID1020510 Css NA 23.21 mg/L 3compartmentss NA 50% Human Human -DTXSID1020510 Css NA 137.2 mg/L 3compartmentss NA 95% Human Human -DTXSID1020510 Css NA 16.17 mg/L PBTK NA 50% Human Human -DTXSID1020510 Css NA 92.25 mg/L PBTK NA 95% Human Human +DTXSID1020510 Fup 0.00603 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020510 Vd NA 3.066 L/kg 1compartment NA NA Human Human +DTXSID1020510 Days.Css NA 142 Days PBTK NA NA Human Human +DTXSID1020510 TK.Half.Life NA 591.9 hours 1compartment NA NA Human Human +DTXSID1020510 Css NA 23.92 mg/L 3compartmentss NA 50% Human Human +DTXSID1020510 Css NA 152.9 mg/L 3compartmentss NA 95% Human Human +DTXSID1020510 Css NA 16.42 mg/L PBTK NA 50% Human Human +DTXSID1020510 Css NA 102.5 mg/L PBTK NA 95% Human Human DTXSID1020510 Clint 3.226 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID1020510 Fup NA 0.0212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020510 Vd NA 2.337 L/kg 1compartment NA NA Rat Human +DTXSID1020510 Fup 0.00603 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020510 Vd NA 2.295 L/kg 1compartment NA NA Rat Human DTXSID1020510 Days.Css NA 76 Days PBTK NA NA Rat Human -DTXSID1020510 TK.Half.Life NA 76.05 hours 1compartment NA NA Rat Human -DTXSID1020510 Css NA 13.13 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020510 Css NA 56.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020510 Css NA 8.678 mg/L PBTK NA 50% Rat Human -DTXSID1020510 Css NA 36.84 mg/L PBTK NA 95% Rat Human +DTXSID1020510 TK.Half.Life NA 82.34 hours 1compartment NA NA Rat Human +DTXSID1020510 Css NA 3.12 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020510 Css NA 14.81 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020510 Css NA 2.128 mg/L PBTK NA 50% Rat Human +DTXSID1020510 Css NA 9.995 mg/L PBTK NA 95% Rat Human DTXSID1020512 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1020512 Fup NA 0.9556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020512 Vd NA 0.8489 L/kg 1compartment NA NA Human Human +DTXSID1020512 Vd NA 0.9037 L/kg 1compartment NA NA Human Human DTXSID1020512 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020512 TK.Half.Life NA 5.762 hours 1compartment NA NA Human Human -DTXSID1020512 Css NA 0.876 mg/L 3compartmentss NA 50% Human Human -DTXSID1020512 Css NA 4.819 mg/L 3compartmentss NA 95% Human Human -DTXSID1020512 Css NA 0.7443 mg/L PBTK NA 50% Human Human -DTXSID1020512 Css NA 3.207 mg/L PBTK NA 95% Human Human +DTXSID1020512 TK.Half.Life NA 6.156 hours 1compartment NA NA Human Human +DTXSID1020512 Css NA 0.7391 mg/L 3compartmentss NA 50% Human Human +DTXSID1020512 Css NA 4.29 mg/L 3compartmentss NA 95% Human Human +DTXSID1020512 Css NA 0.6364 mg/L PBTK NA 50% Human Human +DTXSID1020512 Css NA 2.842 mg/L PBTK NA 95% Human Human DTXSID1020512 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1020512 Fup NA 0.9556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020512 Vd NA 0.8722 L/kg 1compartment NA NA Rat Human +DTXSID1020512 Vd NA 0.9189 L/kg 1compartment NA NA Rat Human DTXSID1020512 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020512 TK.Half.Life NA 2.014 hours 1compartment NA NA Rat Human -DTXSID1020512 Css NA 0.2211 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020512 Css NA 1.215 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020512 Css NA 0.1837 mg/L PBTK NA 50% Rat Human -DTXSID1020512 Css NA 0.7437 mg/L PBTK NA 95% Rat Human +DTXSID1020512 TK.Half.Life NA 2.123 hours 1compartment NA NA Rat Human +DTXSID1020512 Css NA 0.01361 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020512 Css NA 0.1023 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020512 Css NA 0.01121 mg/L PBTK NA 50% Rat Human +DTXSID1020512 Css NA 0.06915 mg/L PBTK NA 95% Rat Human DTXSID1020516 Clint NA 0.0737 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1020516 Fup NA 0.6775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020516 Vd NA 1.026 L/kg 1compartment NA NA Human Human +DTXSID1020516 Vd NA 1.116 L/kg 1compartment NA NA Human Human DTXSID1020516 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020516 TK.Half.Life NA 8.744 hours 1compartment NA NA Human Human -DTXSID1020516 Css NA 0.9224 mg/L 3compartmentss NA 50% Human Human -DTXSID1020516 Css NA 6.62 mg/L 3compartmentss NA 95% Human Human -DTXSID1020516 Css NA 0.7856 mg/L PBTK NA 50% Human Human -DTXSID1020516 Css NA 4.249 mg/L PBTK NA 95% Human Human +DTXSID1020516 TK.Half.Life NA 9.52 hours 1compartment NA NA Human Human +DTXSID1020516 Css NA 0.771 mg/L 3compartmentss NA 50% Human Human +DTXSID1020516 Css NA 5.107 mg/L 3compartmentss NA 95% Human Human +DTXSID1020516 Css NA 0.6709 mg/L PBTK NA 50% Human Human +DTXSID1020516 Css NA 3.316 mg/L PBTK NA 95% Human Human DTXSID1020516 Clint NA 0.0737 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1020516 Fup NA 0.6775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020516 Vd NA 1.047 L/kg 1compartment NA NA Rat Human +DTXSID1020516 Vd NA 1.133 L/kg 1compartment NA NA Rat Human DTXSID1020516 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020516 TK.Half.Life NA 3.218 hours 1compartment NA NA Rat Human -DTXSID1020516 Css NA 0.2578 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020516 Css NA 1.871 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020516 Css NA 0.2119 mg/L PBTK NA 50% Rat Human -DTXSID1020516 Css NA 1.11 mg/L PBTK NA 95% Rat Human +DTXSID1020516 TK.Half.Life NA 3.483 hours 1compartment NA NA Rat Human +DTXSID1020516 Css NA 0.016 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020516 Css NA 0.1412 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020516 Css NA 0.01342 mg/L PBTK NA 50% Rat Human +DTXSID1020516 Css NA 0.09103 mg/L PBTK NA 95% Rat Human DTXSID1020560 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1020560 Fup 0.11 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID1020560 Vd NA 2.847 L/kg 1compartment NA NA Human Human DTXSID1020560 Days.Css NA 277 Days PBTK NA NA Human Human DTXSID1020560 TK.Half.Life NA 1077 hours 1compartment NA NA Human Human -DTXSID1020560 Css NA 51.66 mg/L 3compartmentss NA 50% Human Human -DTXSID1020560 Css NA 145.2 mg/L 3compartmentss NA 95% Human Human -DTXSID1020560 Css NA 31.86 mg/L PBTK NA 50% Human Human -DTXSID1020560 Css NA 86.52 mg/L PBTK NA 95% Human Human +DTXSID1020560 Css NA 36.67 mg/L 3compartmentss NA 50% Human Human +DTXSID1020560 Css NA 100.9 mg/L 3compartmentss NA 95% Human Human +DTXSID1020560 Css NA 30.67 mg/L PBTK NA 50% Human Human +DTXSID1020560 Css NA 84.39 mg/L PBTK NA 95% Human Human DTXSID1020560 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1020560 Fup 0.11 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID1020560 Vd NA 2.142 L/kg 1compartment NA NA Rat Human DTXSID1020560 Days.Css NA 68 Days PBTK NA NA Rat Human DTXSID1020560 TK.Half.Life NA 98.53 hours 1compartment NA NA Rat Human -DTXSID1020560 Css NA 14.16 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020560 Css NA 31.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020560 Css NA 8.24 mg/L PBTK NA 50% Rat Human -DTXSID1020560 Css NA 17.43 mg/L PBTK NA 95% Rat Human -DTXSID1020647 Clint NA 2.592 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020647 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020647 Vd NA 1.043 L/kg 1compartment NA NA Human Human +DTXSID1020560 Css NA 2.215 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020560 Css NA 4.722 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020560 Css NA 1.918 mg/L PBTK NA 50% Rat Human +DTXSID1020560 Css NA 4.089 mg/L PBTK NA 95% Rat Human +DTXSID1020647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020647 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020647 Vd NA 0.6782 L/kg 1compartment NA NA Human Human DTXSID1020647 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020647 TK.Half.Life NA 1.658 hours 1compartment NA NA Human Human -DTXSID1020647 Css NA 0.1538 mg/L 3compartmentss NA 50% Human Human -DTXSID1020647 Css NA 1.216 mg/L 3compartmentss NA 95% Human Human -DTXSID1020647 Css NA 0.1357 mg/L PBTK NA 50% Human Human -DTXSID1020647 Css NA 0.8637 mg/L PBTK NA 95% Human Human -DTXSID1020647 Clint NA 2.592 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020647 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020647 Vd NA 1.033 L/kg 1compartment NA NA Rat Human +DTXSID1020647 TK.Half.Life NA 0.6876 hours 1compartment NA NA Human Human +DTXSID1020647 Css NA 0.03201 mg/L 3compartmentss NA 50% Human Human +DTXSID1020647 Css NA 0.3106 mg/L 3compartmentss NA 95% Human Human +DTXSID1020647 Css NA 0.02448 mg/L PBTK NA 50% Human Human +DTXSID1020647 Css NA 0.2097 mg/L PBTK NA 95% Human Human +DTXSID1020647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020647 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020647 Vd NA 0.6689 L/kg 1compartment NA NA Rat Human DTXSID1020647 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020647 TK.Half.Life NA 0.8491 hours 1compartment NA NA Rat Human -DTXSID1020647 Css NA 0.06587 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020647 Css NA 0.4567 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020647 Css NA 0.05792 mg/L PBTK NA 50% Rat Human -DTXSID1020647 Css NA 0.2862 mg/L PBTK NA 95% Rat Human -DTXSID1020697 Clint NA 144.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020697 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020697 Vd NA 3.044 L/kg 1compartment NA NA Human Human -DTXSID1020697 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020697 TK.Half.Life NA 12.11 hours 1compartment NA NA Human Human -DTXSID1020697 Css NA 0.4109 mg/L 3compartmentss NA 50% Human Human -DTXSID1020697 Css NA 2.576 mg/L 3compartmentss NA 95% Human Human -DTXSID1020697 Css NA 0.2837 mg/L PBTK NA 50% Human Human -DTXSID1020697 Css NA 1.723 mg/L PBTK NA 95% Human Human -DTXSID1020697 Clint NA 144.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020697 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020697 Vd NA 2.28 L/kg 1compartment NA NA Rat Human -DTXSID1020697 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020697 TK.Half.Life NA 2.203 hours 1compartment NA NA Rat Human -DTXSID1020697 Css NA 0.2305 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020697 Css NA 1.244 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020697 Css NA 0.152 mg/L PBTK NA 50% Rat Human -DTXSID1020697 Css NA 0.8037 mg/L PBTK NA 95% Rat Human -DTXSID1020699 Clint NA 43.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020699 Fup NA 0.0691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020699 Vd NA 2.272 L/kg 1compartment NA NA Human Human +DTXSID1020647 TK.Half.Life NA 0.3421 hours 1compartment NA NA Rat Human +DTXSID1020647 Css NA 0.001119 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020647 Css NA 0.01262 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020647 Css NA 0.0008456 mg/L PBTK NA 50% Rat Human +DTXSID1020647 Css NA 0.008238 mg/L PBTK NA 95% Rat Human +DTXSID1020697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020697 Fup 0.0353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020697 Vd NA 3.117 L/kg 1compartment NA NA Human Human +DTXSID1020697 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID1020697 TK.Half.Life NA 82.24 hours 1compartment NA NA Human Human +DTXSID1020697 Css NA 3.096 mg/L 3compartmentss NA 50% Human Human +DTXSID1020697 Css NA 19.74 mg/L 3compartmentss NA 95% Human Human +DTXSID1020697 Css NA 2.152 mg/L PBTK NA 50% Human Human +DTXSID1020697 Css NA 13.39 mg/L PBTK NA 95% Human Human +DTXSID1020697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020697 Fup 0.0353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020697 Vd NA 2.335 L/kg 1compartment NA NA Rat Human +DTXSID1020697 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID1020697 TK.Half.Life NA 11.16 hours 1compartment NA NA Rat Human +DTXSID1020697 Css NA 0.4053 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020697 Css NA 2.275 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020697 Css NA 0.2796 mg/L PBTK NA 50% Rat Human +DTXSID1020697 Css NA 1.511 mg/L PBTK NA 95% Rat Human +DTXSID1020699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020699 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020699 Vd NA 2.038 L/kg 1compartment NA NA Human Human DTXSID1020699 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020699 TK.Half.Life NA 6.564 hours 1compartment NA NA Human Human -DTXSID1020699 Css NA 0.2877 mg/L 3compartmentss NA 50% Human Human -DTXSID1020699 Css NA 2.012 mg/L 3compartmentss NA 95% Human Human -DTXSID1020699 Css NA 0.1946 mg/L PBTK NA 50% Human Human -DTXSID1020699 Css NA 1.299 mg/L PBTK NA 95% Human Human -DTXSID1020699 Clint NA 43.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020699 Fup NA 0.0691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020699 Vd NA 1.707 L/kg 1compartment NA NA Rat Human +DTXSID1020699 TK.Half.Life NA 11.58 hours 1compartment NA NA Human Human +DTXSID1020699 Css NA 0.7405 mg/L 3compartmentss NA 50% Human Human +DTXSID1020699 Css NA 5.467 mg/L 3compartmentss NA 95% Human Human +DTXSID1020699 Css NA 0.4842 mg/L PBTK NA 50% Human Human +DTXSID1020699 Css NA 3.425 mg/L PBTK NA 95% Human Human +DTXSID1020699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020699 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020699 Vd NA 1.526 L/kg 1compartment NA NA Rat Human DTXSID1020699 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020699 TK.Half.Life NA 1.961 hours 1compartment NA NA Rat Human -DTXSID1020699 Css NA 0.1648 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020699 Css NA 0.8511 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020699 Css NA 0.1054 mg/L PBTK NA 50% Rat Human -DTXSID1020699 Css NA 0.5354 mg/L PBTK NA 95% Rat Human +DTXSID1020699 TK.Half.Life NA 0.8807 hours 1compartment NA NA Rat Human +DTXSID1020699 Css NA 0.009398 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020699 Css NA 0.06445 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020699 Css NA 0.006048 mg/L PBTK NA 50% Rat Human +DTXSID1020699 Css NA 0.04013 mg/L PBTK NA 95% Rat Human DTXSID1020728 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1020728 Fup NA 0.8102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020728 Vd NA 1.06 L/kg 1compartment NA NA Human Human +DTXSID1020728 Vd NA 1.033 L/kg 1compartment NA NA Human Human DTXSID1020728 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020728 TK.Half.Life NA 8.465 hours 1compartment NA NA Human Human -DTXSID1020728 Css NA 0.936 mg/L 3compartmentss NA 50% Human Human -DTXSID1020728 Css NA 5.911 mg/L 3compartmentss NA 95% Human Human -DTXSID1020728 Css NA 0.8114 mg/L PBTK NA 50% Human Human -DTXSID1020728 Css NA 3.88 mg/L PBTK NA 95% Human Human +DTXSID1020728 TK.Half.Life NA 8.25 hours 1compartment NA NA Human Human +DTXSID1020728 Css NA 0.8002 mg/L 3compartmentss NA 50% Human Human +DTXSID1020728 Css NA 5.056 mg/L 3compartmentss NA 95% Human Human +DTXSID1020728 Css NA 0.6914 mg/L PBTK NA 50% Human Human +DTXSID1020728 Css NA 3.307 mg/L PBTK NA 95% Human Human DTXSID1020728 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1020728 Fup NA 0.8102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020728 Vd NA 1.095 L/kg 1compartment NA NA Rat Human +DTXSID1020728 Vd NA 1.07 L/kg 1compartment NA NA Rat Human DTXSID1020728 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020728 TK.Half.Life NA 2.98 hours 1compartment NA NA Rat Human -DTXSID1020728 Css NA 0.2376 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020728 Css NA 1.474 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020728 Css NA 0.2008 mg/L PBTK NA 50% Rat Human -DTXSID1020728 Css NA 0.8968 mg/L PBTK NA 95% Rat Human -DTXSID1020803 Clint NA 0.9147 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1020728 TK.Half.Life NA 2.912 hours 1compartment NA NA Rat Human +DTXSID1020728 Css NA 0.01493 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020728 Css NA 0.1192 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020728 Css NA 0.0124 mg/L PBTK NA 50% Rat Human +DTXSID1020728 Css NA 0.07896 mg/L PBTK NA 95% Rat Human +DTXSID1020770 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1020770 Fup NA 0.0122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1020770 Vd NA 3.052 L/kg 1compartment NA NA Human Human +DTXSID1020770 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID1020770 TK.Half.Life NA 38660 hours 1compartment NA NA Human Human +DTXSID1020770 Css NA 1271 mg/L 3compartmentss NA 50% Human Human +DTXSID1020770 Css NA 3655 mg/L 3compartmentss NA 95% Human Human +DTXSID1020770 Css NA 876.2 mg/L PBTK NA 50% Human Human +DTXSID1020770 Css NA 2369 mg/L PBTK NA 95% Human Human +DTXSID1020770 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat +DTXSID1020770 Fup 0.029 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat +DTXSID1020770 Vd NA 2.325 L/kg 1compartment NA NA Rat Rat +DTXSID1020770 Days.Css NA 2696 Days PBTK NA NA Rat Rat +DTXSID1020770 TK.Half.Life NA 2469 hours 1compartment NA NA Rat Rat +DTXSID1020770 Css NA 20.96 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1020770 Css NA 99.5 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1020770 Css NA 14.06 mg/L PBTK NA 50% Rat Rat +DTXSID1020770 Css NA 64.72 mg/L PBTK NA 95% Rat Rat +DTXSID1020803 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1020803 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1020803 Vd NA 0.1763 L/kg 1compartment NA NA Human Human -DTXSID1020803 Days.Css NA 45 Days PBTK NA NA Human Human -DTXSID1020803 TK.Half.Life NA 150.6 hours 1compartment NA NA Human Human -DTXSID1020803 Css NA 81.72 mg/L 3compartmentss NA 50% Human Human -DTXSID1020803 Css NA 624.5 mg/L 3compartmentss NA 95% Human Human -DTXSID1020803 Css NA 88.24 mg/L PBTK NA 50% Human Human -DTXSID1020803 Css NA 455.3 mg/L PBTK NA 95% Human Human -DTXSID1020803 Clint NA 0.9147 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1020803 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID1020803 TK.Half.Life NA 33.37 hours 1compartment NA NA Human Human +DTXSID1020803 Css NA 16.85 mg/L 3compartmentss NA 50% Human Human +DTXSID1020803 Css NA 116.1 mg/L 3compartmentss NA 95% Human Human +DTXSID1020803 Css NA 20.56 mg/L PBTK NA 50% Human Human +DTXSID1020803 Css NA 141.6 mg/L PBTK NA 95% Human Human +DTXSID1020803 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1020803 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1020803 Vd NA 0.1724 L/kg 1compartment NA NA Rat Human -DTXSID1020803 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID1020803 TK.Half.Life NA 72.82 hours 1compartment NA NA Rat Human -DTXSID1020803 Css NA 32.47 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020803 Css NA 211.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020803 Css NA 34.53 mg/L PBTK NA 50% Rat Human -DTXSID1020803 Css NA 144.5 mg/L PBTK NA 95% Rat Human -DTXSID1020805 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020805 Fup NA 0.2199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020805 Vd NA 2.753 L/kg 1compartment NA NA Human Human -DTXSID1020805 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1020805 TK.Half.Life NA 34.64 hours 1compartment NA NA Human Human -DTXSID1020805 Css NA 1.436 mg/L 3compartmentss NA 50% Human Human -DTXSID1020805 Css NA 6.845 mg/L 3compartmentss NA 95% Human Human -DTXSID1020805 Css NA 1.034 mg/L PBTK NA 50% Human Human -DTXSID1020805 Css NA 4.713 mg/L PBTK NA 95% Human Human -DTXSID1020805 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020805 Fup NA 0.2199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020805 Vd NA 2.089 L/kg 1compartment NA NA Rat Human -DTXSID1020805 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1020805 TK.Half.Life NA 6.999 hours 1compartment NA NA Rat Human -DTXSID1020805 Css NA 0.7258 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020805 Css NA 2.481 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020805 Css NA 0.5042 mg/L PBTK NA 50% Rat Human -DTXSID1020805 Css NA 1.629 mg/L PBTK NA 95% Rat Human +DTXSID1020803 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1020803 TK.Half.Life NA 20.95 hours 1compartment NA NA Rat Human +DTXSID1020803 Css NA 1.9 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020803 Css NA 9.901 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020803 Css NA 2.398 mg/L PBTK NA 50% Rat Human +DTXSID1020803 Css NA 12.51 mg/L PBTK NA 95% Rat Human DTXSID1020807 Clint 37.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1020807 Fup 0.0215 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1020807 Vd NA 0.2312 L/kg 1compartment NA NA Human Human DTXSID1020807 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1020807 TK.Half.Life NA 1.302 hours 1compartment NA NA Human Human -DTXSID1020807 Css NA 0.6327 mg/L 3compartmentss NA 50% Human Human -DTXSID1020807 Css NA 5.23 mg/L 3compartmentss NA 95% Human Human -DTXSID1020807 Css NA 0.3762 mg/L PBTK NA 50% Human Human -DTXSID1020807 Css NA 3.049 mg/L PBTK NA 95% Human Human +DTXSID1020807 Css NA 0.6276 mg/L 3compartmentss NA 50% Human Human +DTXSID1020807 Css NA 5.144 mg/L 3compartmentss NA 95% Human Human +DTXSID1020807 Css NA 0.3719 mg/L PBTK NA 50% Human Human +DTXSID1020807 Css NA 3.044 mg/L PBTK NA 95% Human Human DTXSID1020807 Clint 37.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1020807 Fup 0.0215 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1020807 Vd NA 0.212 L/kg 1compartment NA NA Rat Human DTXSID1020807 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1020807 TK.Half.Life NA 0.7697 hours 1compartment NA NA Rat Human -DTXSID1020807 Css NA 0.372 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020807 Css NA 2.287 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020807 Css NA 0.206 mg/L PBTK NA 50% Rat Human -DTXSID1020807 Css NA 1.248 mg/L PBTK NA 95% Rat Human +DTXSID1020807 Css NA 0.08352 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020807 Css NA 0.5342 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020807 Css NA 0.04772 mg/L PBTK NA 50% Rat Human +DTXSID1020807 Css NA 0.303 mg/L PBTK NA 95% Rat Human DTXSID1020809 Clint NA 0.01144 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1020809 Fup NA 0.5301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020809 Vd NA 0.5619 L/kg 1compartment NA NA Human Human +DTXSID1020809 Vd NA 0.5006 L/kg 1compartment NA NA Human Human DTXSID1020809 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020809 TK.Half.Life NA 6.717 hours 1compartment NA NA Human Human -DTXSID1020809 Css NA 1.336 mg/L 3compartmentss NA 50% Human Human -DTXSID1020809 Css NA 7.793 mg/L 3compartmentss NA 95% Human Human -DTXSID1020809 Css NA 1.027 mg/L PBTK NA 50% Human Human -DTXSID1020809 Css NA 4.914 mg/L PBTK NA 95% Human Human +DTXSID1020809 TK.Half.Life NA 5.924 hours 1compartment NA NA Human Human +DTXSID1020809 Css NA 1.16 mg/L 3compartmentss NA 50% Human Human +DTXSID1020809 Css NA 6.545 mg/L 3compartmentss NA 95% Human Human +DTXSID1020809 Css NA 0.8678 mg/L PBTK NA 50% Human Human +DTXSID1020809 Css NA 4.092 mg/L PBTK NA 95% Human Human DTXSID1020809 Clint NA 0.01144 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1020809 Fup NA 0.5301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020809 Vd NA 0.5838 L/kg 1compartment NA NA Rat Human +DTXSID1020809 Vd NA 0.5305 L/kg 1compartment NA NA Rat Human DTXSID1020809 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020809 TK.Half.Life NA 2.403 hours 1compartment NA NA Rat Human -DTXSID1020809 Css NA 0.3732 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020809 Css NA 1.953 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020809 Css NA 0.2728 mg/L PBTK NA 50% Rat Human -DTXSID1020809 Css NA 1.144 mg/L PBTK NA 95% Rat Human +DTXSID1020809 TK.Half.Life NA 2.174 hours 1compartment NA NA Rat Human +DTXSID1020809 Css NA 0.02246 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020809 Css NA 0.1624 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020809 Css NA 0.01633 mg/L PBTK NA 50% Rat Human +DTXSID1020809 Css NA 0.1027 mg/L PBTK NA 95% Rat Human DTXSID1020855 Clint 14.19 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1020855 Fup 0.02832 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1020855 Vd NA 0.7126 L/kg 1compartment NA NA Human Human DTXSID1020855 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1020855 TK.Half.Life NA 6.856 hours 1compartment NA NA Human Human -DTXSID1020855 Css NA 1.658 mg/L 3compartmentss NA 50% Human Human -DTXSID1020855 Css NA 14.65 mg/L 3compartmentss NA 95% Human Human -DTXSID1020855 Css NA 1.003 mg/L PBTK NA 50% Human Human -DTXSID1020855 Css NA 8.562 mg/L PBTK NA 95% Human Human +DTXSID1020855 Css NA 1.595 mg/L 3compartmentss NA 50% Human Human +DTXSID1020855 Css NA 14.03 mg/L 3compartmentss NA 95% Human Human +DTXSID1020855 Css NA 0.964 mg/L PBTK NA 50% Human Human +DTXSID1020855 Css NA 8.261 mg/L PBTK NA 95% Human Human DTXSID1020855 Clint 14.19 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1020855 Fup 0.02832 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1020855 Vd NA 0.5422 L/kg 1compartment NA NA Rat Human DTXSID1020855 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1020855 TK.Half.Life NA 3.212 hours 1compartment NA NA Rat Human -DTXSID1020855 Css NA 0.9021 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020855 Css NA 6.264 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020855 Css NA 0.5115 mg/L PBTK NA 50% Rat Human -DTXSID1020855 Css NA 3.453 mg/L PBTK NA 95% Rat Human -DTXSID1020857 Clint NA 1.965 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020857 Fup NA 0.9158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020857 Vd NA 0.9892 L/kg 1compartment NA NA Human Human +DTXSID1020855 Css NA 0.2061 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020855 Css NA 1.519 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020855 Css NA 0.1201 mg/L PBTK NA 50% Rat Human +DTXSID1020855 Css NA 0.8586 mg/L PBTK NA 95% Rat Human +DTXSID1020857 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020857 Fup 0.639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020857 Vd NA 0.8564 L/kg 1compartment NA NA Human Human DTXSID1020857 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020857 TK.Half.Life NA 1.986 hours 1compartment NA NA Human Human -DTXSID1020857 Css NA 0.203 mg/L 3compartmentss NA 50% Human Human -DTXSID1020857 Css NA 0.9896 mg/L 3compartmentss NA 95% Human Human -DTXSID1020857 Css NA 0.1752 mg/L PBTK NA 50% Human Human -DTXSID1020857 Css NA 0.7264 mg/L PBTK NA 95% Human Human -DTXSID1020857 Clint NA 1.965 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020857 Fup NA 0.9158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020857 Vd NA 0.9781 L/kg 1compartment NA NA Rat Human +DTXSID1020857 TK.Half.Life NA 8.814 hours 1compartment NA NA Human Human +DTXSID1020857 Css NA 1.103 mg/L 3compartmentss NA 50% Human Human +DTXSID1020857 Css NA 7.614 mg/L 3compartmentss NA 95% Human Human +DTXSID1020857 Css NA 0.9166 mg/L PBTK NA 50% Human Human +DTXSID1020857 Css NA 4.939 mg/L PBTK NA 95% Human Human +DTXSID1020857 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020857 Fup 0.639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020857 Vd NA 0.8363 L/kg 1compartment NA NA Rat Human DTXSID1020857 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020857 TK.Half.Life NA 1.003 hours 1compartment NA NA Rat Human -DTXSID1020857 Css NA 0.08408 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020857 Css NA 0.3388 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020857 Css NA 0.07272 mg/L PBTK NA 50% Rat Human -DTXSID1020857 Css NA 0.2277 mg/L PBTK NA 95% Rat Human -DTXSID1020859 Clint NA 1.776 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020859 Fup NA 0.5239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020859 Vd NA 1.201 L/kg 1compartment NA NA Human Human +DTXSID1020857 TK.Half.Life NA 2.897 hours 1compartment NA NA Rat Human +DTXSID1020857 Css NA 0.06704 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020857 Css NA 0.4108 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020857 Css NA 0.05565 mg/L PBTK NA 50% Rat Human +DTXSID1020857 Css NA 0.2536 mg/L PBTK NA 95% Rat Human +DTXSID1020859 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020859 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020859 Vd NA 0.9824 L/kg 1compartment NA NA Human Human DTXSID1020859 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020859 TK.Half.Life NA 4.478 hours 1compartment NA NA Human Human -DTXSID1020859 Css NA 0.3528 mg/L 3compartmentss NA 50% Human Human -DTXSID1020859 Css NA 2.278 mg/L 3compartmentss NA 95% Human Human -DTXSID1020859 Css NA 0.2957 mg/L PBTK NA 50% Human Human -DTXSID1020859 Css NA 1.521 mg/L PBTK NA 95% Human Human -DTXSID1020859 Clint NA 1.776 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020859 Fup NA 0.5239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020859 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID1020859 TK.Half.Life NA 1.144 hours 1compartment NA NA Human Human +DTXSID1020859 Css NA 0.05396 mg/L 3compartmentss NA 50% Human Human +DTXSID1020859 Css NA 0.4156 mg/L 3compartmentss NA 95% Human Human +DTXSID1020859 Css NA 0.04113 mg/L PBTK NA 50% Human Human +DTXSID1020859 Css NA 0.2896 mg/L PBTK NA 95% Human Human +DTXSID1020859 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020859 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020859 Vd NA 0.8664 L/kg 1compartment NA NA Rat Human DTXSID1020859 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020859 TK.Half.Life NA 1.957 hours 1compartment NA NA Rat Human -DTXSID1020859 Css NA 0.1529 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020859 Css NA 0.882 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020859 Css NA 0.1243 mg/L PBTK NA 50% Rat Human -DTXSID1020859 Css NA 0.5409 mg/L PBTK NA 95% Rat Human +DTXSID1020859 TK.Half.Life NA 0.5161 hours 1compartment NA NA Rat Human +DTXSID1020859 Css NA 0.006698 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020859 Css NA 0.04077 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020859 Css NA 0.0051 mg/L PBTK NA 50% Rat Human +DTXSID1020859 Css NA 0.02758 mg/L PBTK NA 95% Rat Human DTXSID1020930 Clint 4.44 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1020930 Fup 0.406 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1020930 Vd NA 0.7058 L/kg 1compartment NA NA Human Human DTXSID1020930 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1020930 TK.Half.Life NA 1.736 hours 1compartment NA NA Human Human -DTXSID1020930 Css NA 0.1925 mg/L 3compartmentss NA 50% Human Human -DTXSID1020930 Css NA 0.9639 mg/L 3compartmentss NA 95% Human Human -DTXSID1020930 Css NA 0.159 mg/L PBTK NA 50% Human Human -DTXSID1020930 Css NA 0.7187 mg/L PBTK NA 95% Human Human +DTXSID1020930 Css NA 0.188 mg/L 3compartmentss NA 50% Human Human +DTXSID1020930 Css NA 0.8556 mg/L 3compartmentss NA 95% Human Human +DTXSID1020930 Css NA 0.1541 mg/L PBTK NA 50% Human Human +DTXSID1020930 Css NA 0.7037 mg/L PBTK NA 95% Human Human DTXSID1020930 Clint 4.44 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1020930 Fup 0.406 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1020930 Vd NA 0.9211 L/kg 1compartment NA NA Rat Human DTXSID1020930 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1020930 TK.Half.Life NA 0.6863 hours 1compartment NA NA Rat Human -DTXSID1020930 Css NA 0.06182 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020930 Css NA 0.3978 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020930 Css NA 0.04642 mg/L PBTK NA 50% Rat Human -DTXSID1020930 Css NA 0.2396 mg/L PBTK NA 95% Rat Human +DTXSID1020930 Css NA 0.01251 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020930 Css NA 0.06511 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020930 Css NA 0.01068 mg/L PBTK NA 50% Rat Human +DTXSID1020930 Css NA 0.05556 mg/L PBTK NA 95% Rat Human DTXSID1020932 Clint 3.54 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1020932 Fup 0.594 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1020932 Vd NA 0.4677 L/kg 1compartment NA NA Human Human DTXSID1020932 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1020932 TK.Half.Life NA 0.9712 hours 1compartment NA NA Human Human -DTXSID1020932 Css NA 0.1644 mg/L 3compartmentss NA 50% Human Human -DTXSID1020932 Css NA 0.7551 mg/L 3compartmentss NA 95% Human Human -DTXSID1020932 Css NA 0.1221 mg/L PBTK NA 50% Human Human -DTXSID1020932 Css NA 0.5315 mg/L PBTK NA 95% Human Human +DTXSID1020932 Css NA 0.158 mg/L 3compartmentss NA 50% Human Human +DTXSID1020932 Css NA 0.7483 mg/L 3compartmentss NA 95% Human Human +DTXSID1020932 Css NA 0.1179 mg/L PBTK NA 50% Human Human +DTXSID1020932 Css NA 0.5209 mg/L PBTK NA 95% Human Human DTXSID1020932 Clint 3.54 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1020932 Fup 0.594 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1020932 Vd NA 0.479 L/kg 1compartment NA NA Rat Human DTXSID1020932 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1020932 TK.Half.Life NA 0.5365 hours 1compartment NA NA Rat Human -DTXSID1020932 Css NA 0.07853 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020932 Css NA 0.2585 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020932 Css NA 0.05729 mg/L PBTK NA 50% Rat Human -DTXSID1020932 Css NA 0.172 mg/L PBTK NA 95% Rat Human +DTXSID1020932 Css NA 0.01742 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020932 Css NA 0.05615 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020932 Css NA 0.01318 mg/L PBTK NA 50% Rat Human +DTXSID1020932 Css NA 0.03915 mg/L PBTK NA 95% Rat Human DTXSID1020982 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1020982 Fup NA 0.5448 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020982 Vd NA 0.4008 L/kg 1compartment NA NA Human Human +DTXSID1020982 Vd NA 0.4005 L/kg 1compartment NA NA Human Human DTXSID1020982 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020982 TK.Half.Life NA 4.761 hours 1compartment NA NA Human Human -DTXSID1020982 Css NA 1.47 mg/L 3compartmentss NA 50% Human Human -DTXSID1020982 Css NA 8.78 mg/L 3compartmentss NA 95% Human Human -DTXSID1020982 Css NA 1.058 mg/L PBTK NA 50% Human Human -DTXSID1020982 Css NA 5.371 mg/L PBTK NA 95% Human Human +DTXSID1020982 TK.Half.Life NA 4.757 hours 1compartment NA NA Human Human +DTXSID1020982 Css NA 1.239 mg/L 3compartmentss NA 50% Human Human +DTXSID1020982 Css NA 7.556 mg/L 3compartmentss NA 95% Human Human +DTXSID1020982 Css NA 0.8846 mg/L PBTK NA 50% Human Human +DTXSID1020982 Css NA 4.665 mg/L PBTK NA 95% Human Human DTXSID1020982 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1020982 Fup NA 0.5448 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020982 Vd NA 0.4213 L/kg 1compartment NA NA Rat Human +DTXSID1020982 Vd NA 0.4211 L/kg 1compartment NA NA Rat Human DTXSID1020982 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020982 TK.Half.Life NA 1.705 hours 1compartment NA NA Rat Human -DTXSID1020982 Css NA 0.3941 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020982 Css NA 2.074 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020982 Css NA 0.2687 mg/L PBTK NA 50% Rat Human -DTXSID1020982 Css NA 1.187 mg/L PBTK NA 95% Rat Human -DTXSID1020984 Clint NA 5.988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020984 Fup NA 0.2622 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1020984 Vd NA 1.116 L/kg 1compartment NA NA Human Human +DTXSID1020982 TK.Half.Life NA 1.704 hours 1compartment NA NA Rat Human +DTXSID1020982 Css NA 0.02376 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020982 Css NA 0.1798 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020982 Css NA 0.01632 mg/L PBTK NA 50% Rat Human +DTXSID1020982 Css NA 0.1094 mg/L PBTK NA 95% Rat Human +DTXSID1020984 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020984 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1020984 Vd NA 0.8577 L/kg 1compartment NA NA Human Human DTXSID1020984 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1020984 TK.Half.Life NA 3.409 hours 1compartment NA NA Human Human -DTXSID1020984 Css NA 0.289 mg/L 3compartmentss NA 50% Human Human -DTXSID1020984 Css NA 1.707 mg/L 3compartmentss NA 95% Human Human -DTXSID1020984 Css NA 0.2112 mg/L PBTK NA 50% Human Human -DTXSID1020984 Css NA 1.164 mg/L PBTK NA 95% Human Human -DTXSID1020984 Clint NA 5.988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020984 Fup NA 0.2622 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1020984 Vd NA 0.9292 L/kg 1compartment NA NA Rat Human +DTXSID1020984 TK.Half.Life NA 3.705 hours 1compartment NA NA Human Human +DTXSID1020984 Css NA 0.492 mg/L 3compartmentss NA 50% Human Human +DTXSID1020984 Css NA 3.17 mg/L 3compartmentss NA 95% Human Human +DTXSID1020984 Css NA 0.3293 mg/L PBTK NA 50% Human Human +DTXSID1020984 Css NA 1.986 mg/L PBTK NA 95% Human Human +DTXSID1020984 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020984 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1020984 Vd NA 0.7113 L/kg 1compartment NA NA Rat Human DTXSID1020984 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1020984 TK.Half.Life NA 1.534 hours 1compartment NA NA Rat Human -DTXSID1020984 Css NA 0.1484 mg/L 3compartmentss NA 50% Rat Human -DTXSID1020984 Css NA 0.6381 mg/L 3compartmentss NA 95% Rat Human -DTXSID1020984 Css NA 0.104 mg/L PBTK NA 50% Rat Human -DTXSID1020984 Css NA 0.4015 mg/L PBTK NA 95% Rat Human +DTXSID1020984 TK.Half.Life NA 1.752 hours 1compartment NA NA Rat Human +DTXSID1020984 Css NA 0.05897 mg/L 3compartmentss NA 50% Rat Human +DTXSID1020984 Css NA 0.2819 mg/L 3compartmentss NA 95% Rat Human +DTXSID1020984 Css NA 0.03894 mg/L PBTK NA 50% Rat Human +DTXSID1020984 Css NA 0.1725 mg/L PBTK NA 95% Rat Human DTXSID1021031 Clint 839 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1021031 Fup 0.123 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1021031 Vd NA 2.097 L/kg 1compartment NA NA Human Human +DTXSID1021031 Vd NA 2.246 L/kg 1compartment NA NA Human Human DTXSID1021031 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021031 TK.Half.Life NA 1.812 hours 1compartment NA NA Human Human -DTXSID1021031 Css NA 0.00746 mg/L 3compartmentss NA 50% Human Human -DTXSID1021031 Css NA 0.05076 mg/L 3compartmentss NA 95% Human Human -DTXSID1021031 Css NA 0.005162 mg/L PBTK NA 50% Human Human -DTXSID1021031 Css NA 0.03392 mg/L PBTK NA 95% Human Human +DTXSID1021031 TK.Half.Life NA 1.949 hours 1compartment NA NA Human Human +DTXSID1021031 Css NA 0.006112 mg/L 3compartmentss NA 50% Human Human +DTXSID1021031 Css NA 0.05202 mg/L 3compartmentss NA 95% Human Human +DTXSID1021031 Css NA 0.004271 mg/L PBTK NA 50% Human Human +DTXSID1021031 Css NA 0.03484 mg/L PBTK NA 95% Human Human DTXSID1021031 Clint 839 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1021031 Fup 0.123 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1021031 Vd NA 1.593 L/kg 1compartment NA NA Rat Human +DTXSID1021031 Vd NA 1.702 L/kg 1compartment NA NA Rat Human DTXSID1021031 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021031 TK.Half.Life NA 0.5986 hours 1compartment NA NA Rat Human -DTXSID1021031 Css NA 0.004176 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021031 Css NA 0.02348 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021031 Css NA 0.002782 mg/L PBTK NA 50% Rat Human -DTXSID1021031 Css NA 0.01501 mg/L PBTK NA 95% Rat Human -DTXSID1021039 Clint NA 0.6238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021039 Fup NA 0.7159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021039 Vd NA 1.559 L/kg 1compartment NA NA Human Human +DTXSID1021031 TK.Half.Life NA 0.6383 hours 1compartment NA NA Rat Human +DTXSID1021031 Css NA 0.0008288 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021031 Css NA 0.00574 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021031 Css NA 0.0005798 mg/L PBTK NA 50% Rat Human +DTXSID1021031 Css NA 0.003879 mg/L PBTK NA 95% Rat Human +DTXSID1021039 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021039 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021039 Vd NA 1.378 L/kg 1compartment NA NA Human Human DTXSID1021039 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021039 TK.Half.Life NA 8.088 hours 1compartment NA NA Human Human -DTXSID1021039 Css NA 0.5022 mg/L 3compartmentss NA 50% Human Human -DTXSID1021039 Css NA 3.483 mg/L 3compartmentss NA 95% Human Human -DTXSID1021039 Css NA 0.4611 mg/L PBTK NA 50% Human Human -DTXSID1021039 Css NA 2.331 mg/L PBTK NA 95% Human Human -DTXSID1021039 Clint NA 0.6238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021039 Fup NA 0.7159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021039 Vd NA 1.39 L/kg 1compartment NA NA Rat Human +DTXSID1021039 TK.Half.Life NA 1.252 hours 1compartment NA NA Human Human +DTXSID1021039 Css NA 0.0338 mg/L 3compartmentss NA 50% Human Human +DTXSID1021039 Css NA 0.3816 mg/L 3compartmentss NA 95% Human Human +DTXSID1021039 Css NA 0.02889 mg/L PBTK NA 50% Human Human +DTXSID1021039 Css NA 0.2652 mg/L PBTK NA 95% Human Human +DTXSID1021039 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021039 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021039 Vd NA 1.225 L/kg 1compartment NA NA Rat Human DTXSID1021039 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021039 TK.Half.Life NA 2.962 hours 1compartment NA NA Rat Human -DTXSID1021039 Css NA 0.1769 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021039 Css NA 1.196 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021039 Css NA 0.1588 mg/L PBTK NA 50% Rat Human -DTXSID1021039 Css NA 0.7426 mg/L PBTK NA 95% Rat Human -DTXSID1021081 Clint NA 1.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021081 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021081 Vd NA 0.2192 L/kg 1compartment NA NA Human Human -DTXSID1021081 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID1021081 TK.Half.Life NA 61.45 hours 1compartment NA NA Human Human -DTXSID1021081 Css NA 50.06 mg/L 3compartmentss NA 50% Human Human -DTXSID1021081 Css NA 365 mg/L 3compartmentss NA 95% Human Human -DTXSID1021081 Css NA 29.6 mg/L PBTK NA 50% Human Human -DTXSID1021081 Css NA 210.8 mg/L PBTK NA 95% Human Human -DTXSID1021081 Clint NA 1.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021081 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021081 Vd NA 0.2101 L/kg 1compartment NA NA Rat Human -DTXSID1021081 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID1021081 TK.Half.Life NA 32.16 hours 1compartment NA NA Rat Human -DTXSID1021081 Css NA 23.01 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021081 Css NA 139 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021081 Css NA 12.61 mg/L PBTK NA 50% Rat Human -DTXSID1021081 Css NA 75.41 mg/L PBTK NA 95% Rat Human +DTXSID1021039 TK.Half.Life NA 0.5424 hours 1compartment NA NA Rat Human +DTXSID1021039 Css NA 0.004127 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021039 Css NA 0.03806 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021039 Css NA 0.003582 mg/L PBTK NA 50% Rat Human +DTXSID1021039 Css NA 0.02605 mg/L PBTK NA 95% Rat Human +DTXSID1021081 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021081 Fup 0.0553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021081 Vd NA 0.2164 L/kg 1compartment NA NA Human Human +DTXSID1021081 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1021081 TK.Half.Life NA 2.16 hours 1compartment NA NA Human Human +DTXSID1021081 Css NA 0.8794 mg/L 3compartmentss NA 50% Human Human +DTXSID1021081 Css NA 6.577 mg/L 3compartmentss NA 95% Human Human +DTXSID1021081 Css NA 0.5238 mg/L PBTK NA 50% Human Human +DTXSID1021081 Css NA 3.832 mg/L PBTK NA 95% Human Human +DTXSID1021081 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021081 Fup 0.0553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021081 Vd NA 0.2186 L/kg 1compartment NA NA Rat Human +DTXSID1021081 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1021081 TK.Half.Life NA 1.366 hours 1compartment NA NA Rat Human +DTXSID1021081 Css NA 0.00934 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021081 Css NA 0.05701 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021081 Css NA 0.005217 mg/L PBTK NA 50% Rat Human +DTXSID1021081 Css NA 0.03155 mg/L PBTK NA 95% Rat Human DTXSID1021087 Clint 3.271 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1021087 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1021087 Vd NA 0.5875 L/kg 1compartment NA NA Human Human DTXSID1021087 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1021087 TK.Half.Life NA 14.69 hours 1compartment NA NA Human Human -DTXSID1021087 Css NA 4.07 mg/L 3compartmentss NA 50% Human Human -DTXSID1021087 Css NA 31.95 mg/L 3compartmentss NA 95% Human Human -DTXSID1021087 Css NA 2.679 mg/L PBTK NA 50% Human Human -DTXSID1021087 Css NA 19.61 mg/L PBTK NA 95% Human Human +DTXSID1021087 Css NA 3.999 mg/L 3compartmentss NA 50% Human Human +DTXSID1021087 Css NA 27.75 mg/L 3compartmentss NA 95% Human Human +DTXSID1021087 Css NA 2.638 mg/L PBTK NA 50% Human Human +DTXSID1021087 Css NA 18.31 mg/L PBTK NA 95% Human Human DTXSID1021087 Clint 3.271 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID1021087 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1021087 Vd NA 0.4655 L/kg 1compartment NA NA Rat Human +DTXSID1021087 Vd 2.4 0.4655 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID1021087 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021087 TK.Half.Life NA 6.769 hours 1compartment NA NA Rat Human -DTXSID1021087 Css NA 2.069 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021087 Css NA 12.64 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021087 Css NA 1.274 mg/L PBTK NA 50% Rat Human -DTXSID1021087 Css NA 7.026 mg/L PBTK NA 95% Rat Human -DTXSID1021089 Clint NA 0.2308 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021089 Fup NA 0.1357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021089 Vd NA 0.3444 L/kg 1compartment NA NA Human Human -DTXSID1021089 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1021089 TK.Half.Life NA 11.83 hours 1compartment NA NA Human Human -DTXSID1021089 Css NA 4.92 mg/L 3compartmentss NA 50% Human Human -DTXSID1021089 Css NA 23.94 mg/L 3compartmentss NA 95% Human Human -DTXSID1021089 Css NA 3.122 mg/L PBTK NA 50% Human Human -DTXSID1021089 Css NA 14.18 mg/L PBTK NA 95% Human Human -DTXSID1021089 Clint NA 0.2308 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021089 Fup NA 0.1357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021089 Vd NA 0.3464 L/kg 1compartment NA NA Rat Human +DTXSID1021087 TK.Half.Life 0.53 6.769 hours 1compartment National Toxicology Program NA Rat Human +DTXSID1021087 Css 0.013 0.4412 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID1021087 Css 0.013 2.432 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID1021087 Css 0.013 0.3016 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID1021087 Css 0.013 1.662 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID1021089 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021089 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021089 Vd NA 0.491 L/kg 1compartment NA NA Human Human +DTXSID1021089 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1021089 TK.Half.Life NA 1.303 hours 1compartment NA NA Human Human +DTXSID1021089 Css NA 0.2396 mg/L 3compartmentss NA 50% Human Human +DTXSID1021089 Css NA 1.48 mg/L 3compartmentss NA 95% Human Human +DTXSID1021089 Css NA 0.1684 mg/L PBTK NA 50% Human Human +DTXSID1021089 Css NA 0.9605 mg/L PBTK NA 95% Human Human +DTXSID1021089 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021089 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021089 Vd NA 0.497 L/kg 1compartment NA NA Rat Human DTXSID1021089 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021089 TK.Half.Life NA 4.735 hours 1compartment NA NA Rat Human -DTXSID1021089 Css NA 1.654 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021089 Css NA 6.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021089 Css NA 0.989 mg/L PBTK NA 50% Rat Human -DTXSID1021089 Css NA 3.736 mg/L PBTK NA 95% Rat Human -DTXSID1021114 Clint NA 26.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021114 Fup NA 0.0421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021114 Vd NA 25.89 L/kg 1compartment NA NA Human Human -DTXSID1021114 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021114 TK.Half.Life NA 6.521 hours 1compartment NA NA Human Human -DTXSID1021114 Css NA 0.004103 mg/L 3compartmentss NA 50% Human Human -DTXSID1021114 Css NA 0.05903 mg/L 3compartmentss NA 95% Human Human -DTXSID1021114 Css NA 0.01209 mg/L PBTK NA 50% Human Human -DTXSID1021114 Css NA 0.09714 mg/L PBTK NA 95% Human Human -DTXSID1021114 Clint NA 26.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021114 Fup NA 0.0421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021114 Vd NA 21.98 L/kg 1compartment NA NA Rat Human -DTXSID1021114 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021114 TK.Half.Life NA 2.702 hours 1compartment NA NA Rat Human -DTXSID1021114 Css NA 0.002168 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021114 Css NA 0.02703 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021114 Css NA 0.006471 mg/L PBTK NA 50% Rat Human -DTXSID1021114 Css NA 0.04348 mg/L PBTK NA 95% Rat Human +DTXSID1021089 TK.Half.Life NA 0.7588 hours 1compartment NA NA Rat Human +DTXSID1021089 Css NA 0.02816 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021089 Css NA 0.1265 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021089 Css NA 0.01965 mg/L PBTK NA 50% Rat Human +DTXSID1021089 Css NA 0.07989 mg/L PBTK NA 95% Rat Human +DTXSID10211069 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID10211069 Fup 0.047 NA NA Williamson 2020 NA Human Human +DTXSID10211069 Vd NA 0.269 L/kg 1compartment NA NA Human Human +DTXSID10211069 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10211069 TK.Half.Life NA 2.529 hours 1compartment NA NA Human Human +DTXSID10211069 Css NA 1.336 mg/L 3compartmentss NA 50% Human Human +DTXSID10211069 Css NA 10.09 mg/L 3compartmentss NA 95% Human Human +DTXSID10211069 Css NA 0.8011 mg/L PBTK NA 50% Human Human +DTXSID10211069 Css NA 5.905 mg/L PBTK NA 95% Human Human +DTXSID10211069 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID10211069 Fup 0.047 NA NA Williamson 2020 NA Rat Human +DTXSID10211069 Vd NA 0.2539 L/kg 1compartment NA NA Rat Human +DTXSID10211069 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10211069 TK.Half.Life NA 1.512 hours 1compartment NA NA Rat Human +DTXSID10211069 Css NA 0.0482 mg/L 3compartmentss NA 50% Rat Human +DTXSID10211069 Css NA 0.4265 mg/L 3compartmentss NA 95% Rat Human +DTXSID10211069 Css NA 0.02734 mg/L PBTK NA 50% Rat Human +DTXSID10211069 Css NA 0.2386 mg/L PBTK NA 95% Rat Human DTXSID1021116 Clint 9.346 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1021116 Fup 0.6 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Human Human -DTXSID1021116 Vd NA 1.44 L/kg 1compartment NA NA Human Human +DTXSID1021116 Vd 1.2 1.44 L/kg 1compartment Raaflaub et al. (1975) NA Human Human DTXSID1021116 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021116 TK.Half.Life NA 1.734 hours 1compartment NA NA Human Human -DTXSID1021116 Css NA 0.06914 mg/L 3compartmentss NA 50% Human Human -DTXSID1021116 Css NA 0.6744 mg/L 3compartmentss NA 95% Human Human -DTXSID1021116 Css NA 0.06337 mg/L PBTK NA 50% Human Human -DTXSID1021116 Css NA 0.4863 mg/L PBTK NA 95% Human Human +DTXSID1021116 TK.Half.Life 0.35 1.734 hours 1compartment Raaflaub et al. (1975) NA Human Human +DTXSID1021116 Css 0.017 0.06662 mg/L 3compartmentss Raaflaub et al. (1975) 50% Human Human +DTXSID1021116 Css 0.017 0.5259 mg/L 3compartmentss Raaflaub et al. (1975) 95% Human Human +DTXSID1021116 Css 0.017 0.06698 mg/L PBTK Raaflaub et al. (1975) 50% Human Human +DTXSID1021116 Css 0.017 0.5303 mg/L PBTK Raaflaub et al. (1975) 95% Human Human DTXSID1021116 Clint 15.4 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1021116 Fup 0.413 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID1021116 Vd NA 1.013 L/kg 1compartment NA NA Rat Rat +DTXSID1021116 Vd 1.4 1.013 L/kg 1compartment Wang et al. (2017), Bao et al. (2012), Seegers et al. (1979), Kobayashi et al. (2012), Wambaugh et al. (2018) NA Rat Rat DTXSID1021116 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID1021116 TK.Half.Life NA 0.6027 hours 1compartment NA NA Rat Rat -DTXSID1021116 Css NA 0.03126 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1021116 Css NA 0.1902 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1021116 Css NA 0.02893 mg/L PBTK NA 50% Rat Rat -DTXSID1021116 Css NA 0.1423 mg/L PBTK NA 95% Rat Rat -DTXSID1021118 Clint NA 6.193 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021118 Fup NA 0.113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021118 Vd NA 0.7886 L/kg 1compartment NA NA Human Human +DTXSID1021116 TK.Half.Life 0.9 0.6027 hours 1compartment Wang et al. (2017), Bao et al. (2012), Seegers et al. (1979), Kobayashi et al. (2012), Wambaugh et al. (2018) NA Rat Rat +DTXSID1021116 Css 0.038 0.006334 mg/L 3compartmentss Wang et al. (2017), Bao et al. (2012), Seegers et al. (1979), Kobayashi et al. (2012), Wambaugh et al. (2018) 50% Rat Rat +DTXSID1021116 Css 0.038 0.03222 mg/L 3compartmentss Wang et al. (2017), Bao et al. (2012), Seegers et al. (1979), Kobayashi et al. (2012), Wambaugh et al. (2018) 95% Rat Rat +DTXSID1021116 Css 0.038 0.00663 mg/L PBTK Wang et al. (2017), Bao et al. (2012), Seegers et al. (1979), Kobayashi et al. (2012), Wambaugh et al. (2018) 50% Rat Rat +DTXSID1021116 Css 0.038 0.0337 mg/L PBTK Wang et al. (2017), Bao et al. (2012), Seegers et al. (1979), Kobayashi et al. (2012), Wambaugh et al. (2018) 95% Rat Rat +DTXSID1021118 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021118 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021118 Vd NA 1.096 L/kg 1compartment NA NA Human Human DTXSID1021118 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021118 TK.Half.Life NA 4.609 hours 1compartment NA NA Human Human -DTXSID1021118 Css NA 0.8122 mg/L 3compartmentss NA 50% Human Human -DTXSID1021118 Css NA 5.555 mg/L 3compartmentss NA 95% Human Human -DTXSID1021118 Css NA 0.5253 mg/L PBTK NA 50% Human Human -DTXSID1021118 Css NA 3.384 mg/L PBTK NA 95% Human Human -DTXSID1021118 Clint NA 6.193 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021118 Fup NA 0.113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021118 Vd NA 0.6537 L/kg 1compartment NA NA Rat Human +DTXSID1021118 TK.Half.Life NA 4.527 hours 1compartment NA NA Human Human +DTXSID1021118 Css NA 0.426 mg/L 3compartmentss NA 50% Human Human +DTXSID1021118 Css NA 2.731 mg/L 3compartmentss NA 95% Human Human +DTXSID1021118 Css NA 0.2953 mg/L PBTK NA 50% Human Human +DTXSID1021118 Css NA 1.763 mg/L PBTK NA 95% Human Human +DTXSID1021118 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021118 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021118 Vd NA 0.9001 L/kg 1compartment NA NA Rat Human DTXSID1021118 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021118 TK.Half.Life NA 2.227 hours 1compartment NA NA Rat Human -DTXSID1021118 Css NA 0.4288 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021118 Css NA 2.172 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021118 Css NA 0.2617 mg/L PBTK NA 50% Rat Human -DTXSID1021118 Css NA 1.241 mg/L PBTK NA 95% Rat Human +DTXSID1021118 TK.Half.Life NA 2.05 hours 1compartment NA NA Rat Human +DTXSID1021118 Css NA 0.05136 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021118 Css NA 0.2309 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021118 Css NA 0.03531 mg/L PBTK NA 50% Rat Human +DTXSID1021118 Css NA 0.1436 mg/L PBTK NA 95% Rat Human DTXSID1021160 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1021160 Fup 0.23 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1021160 Vd NA 0.4603 L/kg 1compartment NA NA Human Human DTXSID1021160 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1021160 TK.Half.Life NA 13.09 hours 1compartment NA NA Human Human -DTXSID1021160 Css NA 3.344 mg/L 3compartmentss NA 50% Human Human -DTXSID1021160 Css NA 9.622 mg/L 3compartmentss NA 95% Human Human -DTXSID1021160 Css NA 2.262 mg/L PBTK NA 50% Human Human -DTXSID1021160 Css NA 6.065 mg/L PBTK NA 95% Human Human +DTXSID1021160 Css NA 3.249 mg/L 3compartmentss NA 50% Human Human +DTXSID1021160 Css NA 9.462 mg/L 3compartmentss NA 95% Human Human +DTXSID1021160 Css NA 2.189 mg/L PBTK NA 50% Human Human +DTXSID1021160 Css NA 6.02 mg/L PBTK NA 95% Human Human DTXSID1021160 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1021160 Fup 0.23 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1021160 Vd NA 0.4288 L/kg 1compartment NA NA Rat Human DTXSID1021160 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1021160 TK.Half.Life NA 4.121 hours 1compartment NA NA Rat Human -DTXSID1021160 Css NA 0.9191 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021160 Css NA 2.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021160 Css NA 0.589 mg/L PBTK NA 50% Rat Human -DTXSID1021160 Css NA 1.262 mg/L PBTK NA 95% Rat Human -DTXSID1021162 Clint NA 4.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021162 Fup NA 0.5438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021162 Vd NA 0.4444 L/kg 1compartment NA NA Human Human +DTXSID1021160 Css NA 0.2076 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021160 Css NA 0.4857 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021160 Css NA 0.1378 mg/L PBTK NA 50% Rat Human +DTXSID1021160 Css NA 0.2954 mg/L PBTK NA 95% Rat Human +DTXSID1021162 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021162 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021162 Vd NA 0.5219 L/kg 1compartment NA NA Human Human DTXSID1021162 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021162 TK.Half.Life NA 0.9081 hours 1compartment NA NA Human Human -DTXSID1021162 Css NA 0.192 mg/L 3compartmentss NA 50% Human Human -DTXSID1021162 Css NA 1.416 mg/L 3compartmentss NA 95% Human Human -DTXSID1021162 Css NA 0.137 mg/L PBTK NA 50% Human Human -DTXSID1021162 Css NA 0.8926 mg/L PBTK NA 95% Human Human -DTXSID1021162 Clint NA 4.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021162 Fup NA 0.5438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021162 Vd NA 0.4538 L/kg 1compartment NA NA Rat Human +DTXSID1021162 TK.Half.Life NA 4.183 hours 1compartment NA NA Human Human +DTXSID1021162 Css NA 1.026 mg/L 3compartmentss NA 50% Human Human +DTXSID1021162 Css NA 6.122 mg/L 3compartmentss NA 95% Human Human +DTXSID1021162 Css NA 0.7851 mg/L PBTK NA 50% Human Human +DTXSID1021162 Css NA 3.913 mg/L PBTK NA 95% Human Human +DTXSID1021162 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021162 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021162 Vd NA 0.538 L/kg 1compartment NA NA Rat Human DTXSID1021162 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021162 TK.Half.Life NA 0.503 hours 1compartment NA NA Rat Human -DTXSID1021162 Css NA 0.09272 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021162 Css NA 0.5844 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021162 Css NA 0.06329 mg/L PBTK NA 50% Rat Human -DTXSID1021162 Css NA 0.3412 mg/L PBTK NA 95% Rat Human +DTXSID1021162 TK.Half.Life NA 1.47 hours 1compartment NA NA Rat Human +DTXSID1021162 Css NA 0.06151 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021162 Css NA 0.3432 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021162 Css NA 0.0469 mg/L PBTK NA 50% Rat Human +DTXSID1021162 Css NA 0.2077 mg/L PBTK NA 95% Rat Human DTXSID1021164 Clint NA 2.327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021164 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021164 Vd NA 1.211 L/kg 1compartment NA NA Human Human DTXSID1021164 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1021164 TK.Half.Life NA 2.375 hours 1compartment NA NA Human Human -DTXSID1021164 Css NA 0.1906 mg/L 3compartmentss NA 50% Human Human -DTXSID1021164 Css NA 1.415 mg/L 3compartmentss NA 95% Human Human -DTXSID1021164 Css NA 0.1723 mg/L PBTK NA 50% Human Human -DTXSID1021164 Css NA 0.9814 mg/L PBTK NA 95% Human Human +DTXSID1021164 Css NA 0.1605 mg/L 3compartmentss NA 50% Human Human +DTXSID1021164 Css NA 1.31 mg/L 3compartmentss NA 95% Human Human +DTXSID1021164 Css NA 0.1434 mg/L PBTK NA 50% Human Human +DTXSID1021164 Css NA 0.8961 mg/L PBTK NA 95% Human Human DTXSID1021164 Clint NA 2.327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1021164 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1021164 Vd NA 1.234 L/kg 1compartment NA NA Rat Human DTXSID1021164 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1021164 TK.Half.Life NA 1.278 hours 1compartment NA NA Rat Human -DTXSID1021164 Css NA 0.08055 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021164 Css NA 0.5821 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021164 Css NA 0.07222 mg/L PBTK NA 50% Rat Human -DTXSID1021164 Css NA 0.3653 mg/L PBTK NA 95% Rat Human +DTXSID1021164 Css NA 0.004871 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021164 Css NA 0.04368 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021164 Css NA 0.004304 mg/L PBTK NA 50% Rat Human +DTXSID1021164 Css NA 0.0305 mg/L PBTK NA 95% Rat Human DTXSID1021166 Clint 76.01 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID1021166 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021166 Vd NA 3.028 L/kg 1compartment NA NA Human Human +DTXSID1021166 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021166 Vd NA 2.757 L/kg 1compartment NA NA Human Human DTXSID1021166 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1021166 TK.Half.Life NA 16.35 hours 1compartment NA NA Human Human -DTXSID1021166 Css NA 0.5993 mg/L 3compartmentss NA 50% Human Human -DTXSID1021166 Css NA 3.788 mg/L 3compartmentss NA 95% Human Human -DTXSID1021166 Css NA 0.4133 mg/L PBTK NA 50% Human Human -DTXSID1021166 Css NA 2.528 mg/L PBTK NA 95% Human Human +DTXSID1021166 TK.Half.Life NA 16.73 hours 1compartment NA NA Human Human +DTXSID1021166 Css NA 0.732 mg/L 3compartmentss NA 50% Human Human +DTXSID1021166 Css NA 5.055 mg/L 3compartmentss NA 95% Human Human +DTXSID1021166 Css NA 0.4909 mg/L PBTK NA 50% Human Human +DTXSID1021166 Css NA 3.316 mg/L PBTK NA 95% Human Human DTXSID1021166 Clint 76.01 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID1021166 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021166 Vd NA 2.269 L/kg 1compartment NA NA Rat Human +DTXSID1021166 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021166 Vd NA 2.058 L/kg 1compartment NA NA Rat Human DTXSID1021166 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021166 TK.Half.Life NA 2.858 hours 1compartment NA NA Rat Human -DTXSID1021166 Css NA 0.3326 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021166 Css NA 1.85 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021166 Css NA 0.2199 mg/L PBTK NA 50% Rat Human -DTXSID1021166 Css NA 1.167 mg/L PBTK NA 95% Rat Human -DTXSID1021168 Clint NA 18.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021168 Fup NA 0.031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021168 Vd NA 3.066 L/kg 1compartment NA NA Human Human +DTXSID1021166 TK.Half.Life NA 3.599 hours 1compartment NA NA Rat Human +DTXSID1021166 Css NA 0.09511 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021166 Css NA 0.6276 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021166 Css NA 0.06282 mg/L PBTK NA 50% Rat Human +DTXSID1021166 Css NA 0.3956 mg/L PBTK NA 95% Rat Human +DTXSID1021168 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021168 Fup 0.0482 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021168 Vd NA 3.114 L/kg 1compartment NA NA Human Human DTXSID1021168 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID1021168 TK.Half.Life NA 73.18 hours 1compartment NA NA Human Human -DTXSID1021168 Css NA 2.968 mg/L 3compartmentss NA 50% Human Human -DTXSID1021168 Css NA 19.08 mg/L 3compartmentss NA 95% Human Human -DTXSID1021168 Css NA 2.052 mg/L PBTK NA 50% Human Human -DTXSID1021168 Css NA 12.63 mg/L PBTK NA 95% Human Human -DTXSID1021168 Clint NA 18.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021168 Fup NA 0.031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021168 Vd NA 2.297 L/kg 1compartment NA NA Rat Human +DTXSID1021168 TK.Half.Life NA 74.72 hours 1compartment NA NA Human Human +DTXSID1021168 Css NA 2.796 mg/L 3compartmentss NA 50% Human Human +DTXSID1021168 Css NA 18.05 mg/L 3compartmentss NA 95% Human Human +DTXSID1021168 Css NA 1.949 mg/L PBTK NA 50% Human Human +DTXSID1021168 Css NA 12.08 mg/L PBTK NA 95% Human Human +DTXSID1021168 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021168 Fup 0.0482 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021168 Vd NA 2.333 L/kg 1compartment NA NA Rat Human DTXSID1021168 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID1021168 TK.Half.Life NA 10.69 hours 1compartment NA NA Rat Human -DTXSID1021168 Css NA 1.646 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021168 Css NA 8.564 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021168 Css NA 1.088 mg/L PBTK NA 50% Rat Human -DTXSID1021168 Css NA 5.608 mg/L PBTK NA 95% Rat Human -DTXSID1021241 Clint NA 1202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021241 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021241 Vd NA 9703 L/kg 1compartment NA NA Human Human -DTXSID1021241 Days.Css NA 1412 Days PBTK NA NA Human Human -DTXSID1021241 TK.Half.Life NA 5311 hours 1compartment NA NA Human Human -DTXSID1021241 Css NA 2.554e-05 mg/L 3compartmentss NA 50% Human Human -DTXSID1021241 Css NA 0.0001562 mg/L 3compartmentss NA 95% Human Human -DTXSID1021241 Css NA 0.04561 mg/L PBTK NA 50% Human Human -DTXSID1021241 Css NA 0.2667 mg/L PBTK NA 95% Human Human -DTXSID1021241 Clint NA 1202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021241 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021241 Vd NA 9126 L/kg 1compartment NA NA Rat Human -DTXSID1021241 Days.Css NA 961 Days PBTK NA NA Rat Human -DTXSID1021241 TK.Half.Life NA 938 hours 1compartment NA NA Rat Human -DTXSID1021241 Css NA 1.303e-05 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021241 Css NA 5.528e-05 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021241 Css NA 0.02484 mg/L PBTK NA 50% Rat Human -DTXSID1021241 Css NA 0.1055 mg/L PBTK NA 95% Rat Human +DTXSID1021168 TK.Half.Life NA 10.24 hours 1compartment NA NA Rat Human +DTXSID1021168 Css NA 0.3641 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021168 Css NA 2.043 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021168 Css NA 0.2514 mg/L PBTK NA 50% Rat Human +DTXSID1021168 Css NA 1.35 mg/L PBTK NA 95% Rat Human DTXSID1021243 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1021243 Fup 3.14e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1021243 Vd NA 0.1722 L/kg 1compartment NA NA Human Human -DTXSID1021243 Days.Css NA 3067 Days PBTK NA NA Human Human -DTXSID1021243 TK.Half.Life NA 11140 hours 1compartment NA NA Human Human -DTXSID1021243 Css NA 71.47 mg/L 3compartmentss NA 50% Human Human -DTXSID1021243 Css NA 925.7 mg/L 3compartmentss NA 95% Human Human -DTXSID1021243 Css NA 45.9 mg/L PBTK NA 50% Human Human -DTXSID1021243 Css NA 545.6 mg/L PBTK NA 95% Human Human +DTXSID1021243 Vd NA 0.3487 L/kg 1compartment NA NA Human Human +DTXSID1021243 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID1021243 TK.Half.Life NA 22570 hours 1compartment NA NA Human Human +DTXSID1021243 Css NA 176 mg/L 3compartmentss NA 50% Human Human +DTXSID1021243 Css NA 1026 mg/L 3compartmentss NA 95% Human Human +DTXSID1021243 Css NA 123 mg/L PBTK NA 50% Human Human +DTXSID1021243 Css NA 632.5 mg/L PBTK NA 95% Human Human DTXSID1021243 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1021243 Fup 3.14e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1021243 Vd NA 0.1671 L/kg 1compartment NA NA Rat Human -DTXSID1021243 Days.Css NA 1014 Days PBTK NA NA Rat Human -DTXSID1021243 TK.Half.Life NA 3683 hours 1compartment NA NA Rat Human -DTXSID1021243 Css NA 22.08 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021243 Css NA 263.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021243 Css NA 13.14 mg/L PBTK NA 50% Rat Human -DTXSID1021243 Css NA 143.8 mg/L PBTK NA 95% Rat Human +DTXSID1021243 Vd NA 0.2757 L/kg 1compartment NA NA Rat Human +DTXSID1021243 Days.Css NA 1680 Days PBTK NA NA Rat Human +DTXSID1021243 TK.Half.Life NA 6080 hours 1compartment NA NA Rat Human +DTXSID1021243 Css NA 3.649 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021243 Css NA 27.69 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021243 Css NA 2.457 mg/L PBTK NA 50% Rat Human +DTXSID1021243 Css NA 16.28 mg/L PBTK NA 95% Rat Human DTXSID1021247 Clint 3.23 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1021247 Fup 0.235 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1021247 Vd NA 0.9468 L/kg 1compartment NA NA Human Human +DTXSID1021247 Vd NA 1.857 L/kg 1compartment NA NA Human Human DTXSID1021247 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021247 TK.Half.Life NA 4.609 hours 1compartment NA NA Human Human -DTXSID1021247 Css NA 0.5556 mg/L 3compartmentss NA 50% Human Human -DTXSID1021247 Css NA 3.186 mg/L 3compartmentss NA 95% Human Human -DTXSID1021247 Css NA 0.4037 mg/L PBTK NA 50% Human Human -DTXSID1021247 Css NA 2.063 mg/L PBTK NA 95% Human Human +DTXSID1021247 TK.Half.Life NA 8.633 hours 1compartment NA NA Human Human +DTXSID1021247 Css NA 0.4515 mg/L 3compartmentss NA 50% Human Human +DTXSID1021247 Css NA 2.834 mg/L 3compartmentss NA 95% Human Human +DTXSID1021247 Css NA 0.3814 mg/L PBTK NA 50% Human Human +DTXSID1021247 Css NA 2.008 mg/L PBTK NA 95% Human Human DTXSID1021247 Clint 3.23 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1021247 Fup 0.235 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1021247 Vd NA 0.9489 L/kg 1compartment NA NA Rat Human +DTXSID1021247 Vd NA 1.865 L/kg 1compartment NA NA Rat Human DTXSID1021247 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021247 TK.Half.Life NA 2.639 hours 1compartment NA NA Rat Human -DTXSID1021247 Css NA 0.269 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021247 Css NA 1.159 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021247 Css NA 0.1862 mg/L PBTK NA 50% Rat Human -DTXSID1021247 Css NA 0.6988 mg/L PBTK NA 95% Rat Human -DTXSID1021291 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021291 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021291 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID1021291 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021291 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID1021291 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID1021291 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID1021291 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID1021291 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID1021291 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021291 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021291 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human -DTXSID1021291 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021291 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID1021291 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021291 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021291 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID1021291 Css NA 1.296 mg/L PBTK NA 95% Rat Human +DTXSID1021247 TK.Half.Life NA 4.99 hours 1compartment NA NA Rat Human +DTXSID1021247 Css NA 0.04924 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021247 Css NA 0.2341 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021247 Css NA 0.0422 mg/L PBTK NA 50% Rat Human +DTXSID1021247 Css NA 0.1579 mg/L PBTK NA 95% Rat Human DTXSID1021299 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1021299 Fup 7.84e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1021299 Vd NA 1.712 L/kg 1compartment NA NA Human Human -DTXSID1021299 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID1021299 TK.Half.Life NA 110800 hours 1compartment NA NA Human Human -DTXSID1021299 Css NA 3044 mg/L 3compartmentss NA 50% Human Human -DTXSID1021299 Css NA 8257 mg/L 3compartmentss NA 95% Human Human -DTXSID1021299 Css NA 2105 mg/L PBTK NA 50% Human Human -DTXSID1021299 Css NA 5283 mg/L PBTK NA 95% Human Human +DTXSID1021299 Vd NA 4.728 L/kg 1compartment NA NA Human Human +DTXSID1021299 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID1021299 TK.Half.Life NA 306000 hours 1compartment NA NA Human Human +DTXSID1021299 Css NA 4160 mg/L 3compartmentss NA 50% Human Human +DTXSID1021299 Css NA 9455 mg/L 3compartmentss NA 95% Human Human +DTXSID1021299 Css NA 3603 mg/L PBTK NA 50% Human Human +DTXSID1021299 Css NA 7701 mg/L PBTK NA 95% Human Human DTXSID1021299 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1021299 Fup 7.84e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1021299 Vd NA 1.257 L/kg 1compartment NA NA Rat Human -DTXSID1021299 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID1021299 TK.Half.Life NA 27710 hours 1compartment NA NA Rat Human -DTXSID1021299 Css NA 831.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021299 Css NA 1953 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021299 Css NA 549.3 mg/L PBTK NA 50% Rat Human -DTXSID1021299 Css NA 1166 mg/L PBTK NA 95% Rat Human -DTXSID1021320 Clint NA 444.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021320 Fup NA 0.0135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021320 Vd NA 1.326 L/kg 1compartment NA NA Human Human -DTXSID1021320 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021320 TK.Half.Life NA 1.955 hours 1compartment NA NA Human Human -DTXSID1021320 Css NA 0.09968 mg/L 3compartmentss NA 50% Human Human -DTXSID1021320 Css NA 0.9488 mg/L 3compartmentss NA 95% Human Human -DTXSID1021320 Css NA 0.06144 mg/L PBTK NA 50% Human Human -DTXSID1021320 Css NA 0.5702 mg/L PBTK NA 95% Human Human -DTXSID1021320 Clint NA 444.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021320 Fup NA 0.0135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021320 Vd NA 0.9799 L/kg 1compartment NA NA Rat Human +DTXSID1021299 Vd NA 3.602 L/kg 1compartment NA NA Rat Human +DTXSID1021299 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID1021299 TK.Half.Life NA 79420 hours 1compartment NA NA Rat Human +DTXSID1021299 Css NA 266.5 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021299 Css NA 388.8 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021299 Css NA 233.9 mg/L PBTK NA 50% Rat Human +DTXSID1021299 Css NA 311.1 mg/L PBTK NA 95% Rat Human +DTXSID1021320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021320 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021320 Vd NA 1.81 L/kg 1compartment NA NA Human Human +DTXSID1021320 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1021320 TK.Half.Life NA 13.81 hours 1compartment NA NA Human Human +DTXSID1021320 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human +DTXSID1021320 Css NA 9.571 mg/L 3compartmentss NA 95% Human Human +DTXSID1021320 Css NA 0.7096 mg/L PBTK NA 50% Human Human +DTXSID1021320 Css NA 5.797 mg/L PBTK NA 95% Human Human +DTXSID1021320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021320 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021320 Vd NA 1.347 L/kg 1compartment NA NA Rat Human DTXSID1021320 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021320 TK.Half.Life NA 0.7029 hours 1compartment NA NA Rat Human -DTXSID1021320 Css NA 0.05647 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021320 Css NA 0.4561 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021320 Css NA 0.0325 mg/L PBTK NA 50% Rat Human -DTXSID1021320 Css NA 0.2547 mg/L PBTK NA 95% Rat Human +DTXSID1021320 TK.Half.Life NA 4.8 hours 1compartment NA NA Rat Human +DTXSID1021320 Css NA 0.145 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021320 Css NA 0.9501 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021320 Css NA 0.0901 mg/L PBTK NA 50% Rat Human +DTXSID1021320 Css NA 0.5723 mg/L PBTK NA 95% Rat Human DTXSID1021322 Clint 28.46 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID1021322 Fup 0.08601 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID1021322 Vd NA 2.872 L/kg 1compartment NA NA Human Human DTXSID1021322 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1021322 TK.Half.Life NA 7.487 hours 1compartment NA NA Human Human -DTXSID1021322 Css NA 0.2266 mg/L 3compartmentss NA 50% Human Human -DTXSID1021322 Css NA 1.439 mg/L 3compartmentss NA 95% Human Human -DTXSID1021322 Css NA 0.1745 mg/L PBTK NA 50% Human Human -DTXSID1021322 Css NA 1.027 mg/L PBTK NA 95% Human Human +DTXSID1021322 Css NA 0.2178 mg/L 3compartmentss NA 50% Human Human +DTXSID1021322 Css NA 1.504 mg/L 3compartmentss NA 95% Human Human +DTXSID1021322 Css NA 0.1683 mg/L PBTK NA 50% Human Human +DTXSID1021322 Css NA 1.079 mg/L PBTK NA 95% Human Human DTXSID1021322 Clint 28.46 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID1021322 Fup 0.08601 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID1021322 Vd NA 2.376 L/kg 1compartment NA NA Rat Human DTXSID1021322 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1021322 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human -DTXSID1021322 Css NA 0.125 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021322 Css NA 0.6678 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021322 Css NA 0.09262 mg/L PBTK NA 50% Rat Human -DTXSID1021322 Css NA 0.4634 mg/L PBTK NA 95% Rat Human -DTXSID1021372 Clint NA 39.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021372 Fup NA 0.252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021372 Vd NA 1.175 L/kg 1compartment NA NA Human Human +DTXSID1021322 Css NA 0.02803 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021322 Css NA 0.1618 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021322 Css NA 0.02155 mg/L PBTK NA 50% Rat Human +DTXSID1021322 Css NA 0.1157 mg/L PBTK NA 95% Rat Human +DTXSID10213609 Clint 29 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Human Human +DTXSID10213609 Fup 0.069 NA NA Williamson 2020 NA Human Human +DTXSID10213609 Vd NA 2.338 L/kg 1compartment NA NA Human Human +DTXSID10213609 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10213609 TK.Half.Life NA 9.45 hours 1compartment NA NA Human Human +DTXSID10213609 Css NA 0.4056 mg/L 3compartmentss NA 50% Human Human +DTXSID10213609 Css NA 2.834 mg/L 3compartmentss NA 95% Human Human +DTXSID10213609 Css NA 0.2722 mg/L PBTK NA 50% Human Human +DTXSID10213609 Css NA 1.847 mg/L PBTK NA 95% Human Human +DTXSID10213609 Clint 29 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Rat Human +DTXSID10213609 Fup 0.069 NA NA Williamson 2020 NA Rat Human +DTXSID10213609 Vd NA 1.758 L/kg 1compartment NA NA Rat Human +DTXSID10213609 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10213609 TK.Half.Life NA 2.702 hours 1compartment NA NA Rat Human +DTXSID10213609 Css NA 0.02048 mg/L 3compartmentss NA 50% Rat Human +DTXSID10213609 Css NA 0.1466 mg/L 3compartmentss NA 95% Rat Human +DTXSID10213609 Css NA 0.01336 mg/L PBTK NA 50% Rat Human +DTXSID10213609 Css NA 0.09161 mg/L PBTK NA 95% Rat Human +DTXSID1021372 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021372 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021372 Vd NA 1.208 L/kg 1compartment NA NA Human Human DTXSID1021372 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021372 TK.Half.Life NA 1.347 hours 1compartment NA NA Human Human -DTXSID1021372 Css NA 0.04989 mg/L 3compartmentss NA 50% Human Human -DTXSID1021372 Css NA 0.3693 mg/L 3compartmentss NA 95% Human Human -DTXSID1021372 Css NA 0.03652 mg/L PBTK NA 50% Human Human -DTXSID1021372 Css NA 0.2508 mg/L PBTK NA 95% Human Human -DTXSID1021372 Clint NA 39.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021372 Fup NA 0.252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021372 Vd NA 0.9711 L/kg 1compartment NA NA Rat Human +DTXSID1021372 TK.Half.Life NA 1.918 hours 1compartment NA NA Human Human +DTXSID1021372 Css NA 0.1013 mg/L 3compartmentss NA 50% Human Human +DTXSID1021372 Css NA 0.6822 mg/L 3compartmentss NA 95% Human Human +DTXSID1021372 Css NA 0.07295 mg/L PBTK NA 50% Human Human +DTXSID1021372 Css NA 0.4587 mg/L PBTK NA 95% Human Human +DTXSID1021372 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021372 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021372 Vd NA 0.9847 L/kg 1compartment NA NA Rat Human DTXSID1021372 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021372 TK.Half.Life NA 0.5501 hours 1compartment NA NA Rat Human -DTXSID1021372 Css NA 0.02719 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021372 Css NA 0.1568 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021372 Css NA 0.0189 mg/L PBTK NA 50% Rat Human -DTXSID1021372 Css NA 0.1003 mg/L PBTK NA 95% Rat Human +DTXSID1021372 TK.Half.Life NA 0.8096 hours 1compartment NA NA Rat Human +DTXSID1021372 Css NA 0.01266 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021372 Css NA 0.07017 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021372 Css NA 0.009062 mg/L PBTK NA 50% Rat Human +DTXSID1021372 Css NA 0.04686 mg/L PBTK NA 95% Rat Human DTXSID1021378 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021378 Fup NA 0.2836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021378 Vd NA 0.538 L/kg 1compartment NA NA Human Human DTXSID1021378 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1021378 TK.Half.Life NA 12.27 hours 1compartment NA NA Human Human -DTXSID1021378 Css NA 2.61 mg/L 3compartmentss NA 50% Human Human -DTXSID1021378 Css NA 10.35 mg/L 3compartmentss NA 95% Human Human -DTXSID1021378 Css NA 1.878 mg/L PBTK NA 50% Human Human -DTXSID1021378 Css NA 6.599 mg/L PBTK NA 95% Human Human +DTXSID1021378 Css NA 2.196 mg/L 3compartmentss NA 50% Human Human +DTXSID1021378 Css NA 8.741 mg/L 3compartmentss NA 95% Human Human +DTXSID1021378 Css NA 1.596 mg/L PBTK NA 50% Human Human +DTXSID1021378 Css NA 5.544 mg/L PBTK NA 95% Human Human DTXSID1021378 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1021378 Fup NA 0.2836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1021378 Vd NA 0.5416 L/kg 1compartment NA NA Rat Human DTXSID1021378 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1021378 TK.Half.Life NA 4.211 hours 1compartment NA NA Rat Human -DTXSID1021378 Css NA 0.7121 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021378 Css NA 2.385 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021378 Css NA 0.4913 mg/L PBTK NA 50% Rat Human -DTXSID1021378 Css NA 1.413 mg/L PBTK NA 95% Rat Human -DTXSID1021403 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1021378 Css NA 0.0391 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021378 Css NA 0.241 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021378 Css NA 0.02746 mg/L PBTK NA 50% Rat Human +DTXSID1021378 Css NA 0.1552 mg/L PBTK NA 95% Rat Human +DTXSID1021403 Clint 3.43 NA uL/min/million hepatocytes NA Black 2021 NA Human Human DTXSID1021403 Fup NA 0.8056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021403 Vd NA 0.727 L/kg 1compartment NA NA Human Human DTXSID1021403 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021403 TK.Half.Life NA 5.844 hours 1compartment NA NA Human Human -DTXSID1021403 Css NA 0.995 mg/L 3compartmentss NA 50% Human Human -DTXSID1021403 Css NA 5.784 mg/L 3compartmentss NA 95% Human Human -DTXSID1021403 Css NA 0.818 mg/L PBTK NA 50% Human Human -DTXSID1021403 Css NA 3.727 mg/L PBTK NA 95% Human Human +DTXSID1021403 TK.Half.Life NA 1.194 hours 1compartment NA NA Human Human +DTXSID1021403 Css NA 0.1312 mg/L 3compartmentss NA 50% Human Human +DTXSID1021403 Css NA 0.9879 mg/L 3compartmentss NA 95% Human Human +DTXSID1021403 Css NA 0.1059 mg/L PBTK NA 50% Human Human +DTXSID1021403 Css NA 0.667 mg/L PBTK NA 95% Human Human DTXSID1021403 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1021403 Fup 0.8835 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1021403 Vd NA 0.7966 L/kg 1compartment NA NA Rat Rat DTXSID1021403 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID1021403 TK.Half.Life NA 1.988 hours 1compartment NA NA Rat Rat -DTXSID1021403 Css NA 0.2364 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1021403 Css NA 1.369 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1021403 Css NA 0.1914 mg/L PBTK NA 50% Rat Rat -DTXSID1021403 Css NA 0.8247 mg/L PBTK NA 95% Rat Rat -DTXSID1021405 Clint NA 12.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021405 Fup NA 0.0938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021405 Vd NA 2.813 L/kg 1compartment NA NA Human Human -DTXSID1021405 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1021405 TK.Half.Life NA 30.97 hours 1compartment NA NA Human Human -DTXSID1021405 Css NA 1.36 mg/L 3compartmentss NA 50% Human Human -DTXSID1021405 Css NA 8.656 mg/L 3compartmentss NA 95% Human Human -DTXSID1021405 Css NA 0.942 mg/L PBTK NA 50% Human Human -DTXSID1021405 Css NA 5.672 mg/L PBTK NA 95% Human Human -DTXSID1021405 Clint NA 12.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021405 Fup NA 0.0938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021405 Vd NA 2.114 L/kg 1compartment NA NA Rat Human -DTXSID1021405 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1021405 TK.Half.Life NA 6.129 hours 1compartment NA NA Rat Human -DTXSID1021405 Css NA 0.7434 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021405 Css NA 3.433 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021405 Css NA 0.4938 mg/L PBTK NA 50% Rat Human -DTXSID1021405 Css NA 2.153 mg/L PBTK NA 95% Rat Human -DTXSID1021409 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID1021409 Fup NA 0.0095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021409 Vd NA 2.937 L/kg 1compartment NA NA Human Human -DTXSID1021409 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID1021409 TK.Half.Life NA 20710 hours 1compartment NA NA Human Human -DTXSID1021409 Css NA 870.7 mg/L 3compartmentss NA 50% Human Human -DTXSID1021409 Css NA 2614 mg/L 3compartmentss NA 95% Human Human -DTXSID1021409 Css NA 594.3 mg/L PBTK NA 50% Human Human -DTXSID1021409 Css NA 1640 mg/L PBTK NA 95% Human Human -DTXSID1021409 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID1021409 Fup NA 0.0095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021409 Vd NA 2.197 L/kg 1compartment NA NA Rat Human -DTXSID1021409 Days.Css NA 1453 Days PBTK NA NA Rat Human -DTXSID1021409 TK.Half.Life NA 1647 hours 1compartment NA NA Rat Human -DTXSID1021409 Css NA 237.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021409 Css NA 583 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021409 Css NA 154.3 mg/L PBTK NA 50% Rat Human -DTXSID1021409 Css NA 343.6 mg/L PBTK NA 95% Rat Human -DTXSID1021455 Clint NA 2.851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021455 Fup NA 0.0543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021455 Vd NA 0.2165 L/kg 1compartment NA NA Human Human +DTXSID1021403 Css NA 0.01479 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1021403 Css NA 0.1094 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1021403 Css NA 0.01174 mg/L PBTK NA 50% Rat Rat +DTXSID1021403 Css NA 0.07074 mg/L PBTK NA 95% Rat Rat +DTXSID1021405 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021405 Fup 0.00948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021405 Vd NA 2.816 L/kg 1compartment NA NA Human Human +DTXSID1021405 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID1021405 TK.Half.Life NA 59.45 hours 1compartment NA NA Human Human +DTXSID1021405 Css NA 2.786 mg/L 3compartmentss NA 50% Human Human +DTXSID1021405 Css NA 19.88 mg/L 3compartmentss NA 95% Human Human +DTXSID1021405 Css NA 1.883 mg/L PBTK NA 50% Human Human +DTXSID1021405 Css NA 12.68 mg/L PBTK NA 95% Human Human +DTXSID1021405 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021405 Fup 0.00948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021405 Vd NA 2.103 L/kg 1compartment NA NA Rat Human +DTXSID1021405 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID1021405 TK.Half.Life NA 11.35 hours 1compartment NA NA Rat Human +DTXSID1021405 Css NA 0.3622 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021405 Css NA 2.23 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021405 Css NA 0.2408 mg/L PBTK NA 50% Rat Human +DTXSID1021405 Css NA 1.436 mg/L PBTK NA 95% Rat Human +DTXSID1021455 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021455 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021455 Vd NA 0.2099 L/kg 1compartment NA NA Human Human DTXSID1021455 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021455 TK.Half.Life NA 4.492 hours 1compartment NA NA Human Human -DTXSID1021455 Css NA 3.584 mg/L 3compartmentss NA 50% Human Human -DTXSID1021455 Css NA 22.03 mg/L 3compartmentss NA 95% Human Human -DTXSID1021455 Css NA 2.142 mg/L PBTK NA 50% Human Human -DTXSID1021455 Css NA 12.66 mg/L PBTK NA 95% Human Human -DTXSID1021455 Clint NA 2.851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021455 Fup NA 0.0543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021455 Vd NA 0.2168 L/kg 1compartment NA NA Rat Human +DTXSID1021455 TK.Half.Life NA 1.258 hours 1compartment NA NA Human Human +DTXSID1021455 Css NA 0.482 mg/L 3compartmentss NA 50% Human Human +DTXSID1021455 Css NA 3.714 mg/L 3compartmentss NA 95% Human Human +DTXSID1021455 Css NA 0.2875 mg/L PBTK NA 50% Human Human +DTXSID1021455 Css NA 2.19 mg/L PBTK NA 95% Human Human +DTXSID1021455 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021455 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021455 Vd NA 0.2141 L/kg 1compartment NA NA Rat Human DTXSID1021455 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021455 TK.Half.Life NA 2.64 hours 1compartment NA NA Rat Human -DTXSID1021455 Css NA 1.759 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021455 Css NA 8.494 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021455 Css NA 0.9822 mg/L PBTK NA 50% Rat Human -DTXSID1021455 Css NA 4.627 mg/L PBTK NA 95% Rat Human -DTXSID1021530 Clint NA 0.2566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021530 Fup NA 0.7822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021530 Vd NA 1.758 L/kg 1compartment NA NA Human Human -DTXSID1021530 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1021530 TK.Half.Life NA 12.84 hours 1compartment NA NA Human Human -DTXSID1021530 Css NA 0.6892 mg/L 3compartmentss NA 50% Human Human -DTXSID1021530 Css NA 4.294 mg/L 3compartmentss NA 95% Human Human -DTXSID1021530 Css NA 0.644 mg/L PBTK NA 50% Human Human -DTXSID1021530 Css NA 2.895 mg/L PBTK NA 95% Human Human -DTXSID1021530 Clint NA 0.2566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021530 Fup NA 0.7822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021530 Vd NA 1.514 L/kg 1compartment NA NA Rat Human +DTXSID1021455 TK.Half.Life NA 0.8 hours 1compartment NA NA Rat Human +DTXSID1021455 Css NA 0.005097 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021455 Css NA 0.03371 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021455 Css NA 0.002855 mg/L PBTK NA 50% Rat Human +DTXSID1021455 Css NA 0.01855 mg/L PBTK NA 95% Rat Human +DTXSID1021530 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021530 Fup 0.538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021530 Vd NA 1.179 L/kg 1compartment NA NA Human Human +DTXSID1021530 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1021530 TK.Half.Life NA 1.113 hours 1compartment NA NA Human Human +DTXSID1021530 Css NA 0.03592 mg/L 3compartmentss NA 50% Human Human +DTXSID1021530 Css NA 0.3653 mg/L 3compartmentss NA 95% Human Human +DTXSID1021530 Css NA 0.02981 mg/L PBTK NA 50% Human Human +DTXSID1021530 Css NA 0.2587 mg/L PBTK NA 95% Human Human +DTXSID1021530 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021530 Fup 0.538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021530 Vd NA 1.05 L/kg 1compartment NA NA Rat Human DTXSID1021530 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021530 TK.Half.Life NA 3.745 hours 1compartment NA NA Rat Human -DTXSID1021530 Css NA 0.2186 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021530 Css NA 1.366 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021530 Css NA 0.1986 mg/L PBTK NA 50% Rat Human -DTXSID1021530 Css NA 0.8594 mg/L PBTK NA 95% Rat Human +DTXSID1021530 TK.Half.Life NA 0.4892 hours 1compartment NA NA Rat Human +DTXSID1021530 Css NA 0.004402 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021530 Css NA 0.03488 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021530 Css NA 0.003683 mg/L PBTK NA 50% Rat Human +DTXSID1021530 Css NA 0.02345 mg/L PBTK NA 95% Rat Human +DTXSID1021584 Clint NA 37.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1021584 Fup NA 0.4893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1021584 Vd NA 2.534 L/kg 1compartment NA NA Human Human +DTXSID1021584 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1021584 TK.Half.Life NA 2.869 hours 1compartment NA NA Human Human +DTXSID1021584 Css NA 0.04966 mg/L 3compartmentss NA 50% Human Human +DTXSID1021584 Css NA 0.3694 mg/L 3compartmentss NA 95% Human Human +DTXSID1021584 Css NA 0.03961 mg/L PBTK NA 50% Human Human +DTXSID1021584 Css NA 0.2689 mg/L PBTK NA 95% Human Human +DTXSID1021584 Clint NA 37.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1021584 Fup NA 0.4893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1021584 Vd NA 1.981 L/kg 1compartment NA NA Rat Human +DTXSID1021584 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1021584 TK.Half.Life NA 0.8876 hours 1compartment NA NA Rat Human +DTXSID1021584 Css NA 0.00632 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021584 Css NA 0.0359 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021584 Css NA 0.005067 mg/L PBTK NA 50% Rat Human +DTXSID1021584 Css NA 0.02669 mg/L PBTK NA 95% Rat Human +DTXSID1021586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021586 Fup 0.0377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021586 Vd NA 2.916 L/kg 1compartment NA NA Human Human +DTXSID1021586 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1021586 TK.Half.Life NA 39.05 hours 1compartment NA NA Human Human +DTXSID1021586 Css NA 1.654 mg/L 3compartmentss NA 50% Human Human +DTXSID1021586 Css NA 11.11 mg/L 3compartmentss NA 95% Human Human +DTXSID1021586 Css NA 1.134 mg/L PBTK NA 50% Human Human +DTXSID1021586 Css NA 7.339 mg/L PBTK NA 95% Human Human +DTXSID1021586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021586 Fup 0.0377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021586 Vd NA 2.185 L/kg 1compartment NA NA Rat Human +DTXSID1021586 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1021586 TK.Half.Life NA 6.954 hours 1compartment NA NA Rat Human +DTXSID1021586 Css NA 0.215 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021586 Css NA 1.193 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021586 Css NA 0.1451 mg/L PBTK NA 50% Rat Human +DTXSID1021586 Css NA 0.7738 mg/L PBTK NA 95% Rat Human DTXSID1021615 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021615 Fup NA 0.9374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021615 Vd NA 0.975 L/kg 1compartment NA NA Human Human +DTXSID1021615 Vd NA 0.9546 L/kg 1compartment NA NA Human Human DTXSID1021615 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021615 TK.Half.Life NA 6.809 hours 1compartment NA NA Human Human -DTXSID1021615 Css NA 0.8246 mg/L 3compartmentss NA 50% Human Human -DTXSID1021615 Css NA 3.129 mg/L 3compartmentss NA 95% Human Human -DTXSID1021615 Css NA 0.7245 mg/L PBTK NA 50% Human Human -DTXSID1021615 Css NA 2.205 mg/L PBTK NA 95% Human Human +DTXSID1021615 TK.Half.Life NA 6.658 hours 1compartment NA NA Human Human +DTXSID1021615 Css NA 0.7024 mg/L 3compartmentss NA 50% Human Human +DTXSID1021615 Css NA 2.668 mg/L 3compartmentss NA 95% Human Human +DTXSID1021615 Css NA 0.6135 mg/L PBTK NA 50% Human Human +DTXSID1021615 Css NA 1.921 mg/L PBTK NA 95% Human Human DTXSID1021615 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1021615 Fup NA 0.9374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021615 Vd NA 0.974 L/kg 1compartment NA NA Rat Human +DTXSID1021615 Vd NA 0.958 L/kg 1compartment NA NA Rat Human DTXSID1021615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021615 TK.Half.Life NA 2.297 hours 1compartment NA NA Rat Human -DTXSID1021615 Css NA 0.2112 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021615 Css NA 0.7219 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021615 Css NA 0.1822 mg/L PBTK NA 50% Rat Human -DTXSID1021615 Css NA 0.4785 mg/L PBTK NA 95% Rat Human -DTXSID1021617 Clint NA 0.047 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021617 Fup NA 0.113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021617 Vd NA 0.3448 L/kg 1compartment NA NA Human Human -DTXSID1021617 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1021617 TK.Half.Life NA 18.31 hours 1compartment NA NA Human Human -DTXSID1021617 Css NA 7.893 mg/L 3compartmentss NA 50% Human Human -DTXSID1021617 Css NA 38.68 mg/L 3compartmentss NA 95% Human Human -DTXSID1021617 Css NA 5.048 mg/L PBTK NA 50% Human Human -DTXSID1021617 Css NA 22.79 mg/L PBTK NA 95% Human Human -DTXSID1021617 Clint NA 0.047 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021617 Fup NA 0.113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021617 Vd NA 0.3387 L/kg 1compartment NA NA Rat Human +DTXSID1021615 TK.Half.Life NA 2.259 hours 1compartment NA NA Rat Human +DTXSID1021615 Css NA 0.01256 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021615 Css NA 0.06901 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021615 Css NA 0.0107 mg/L PBTK NA 50% Rat Human +DTXSID1021615 Css NA 0.05143 mg/L PBTK NA 95% Rat Human +DTXSID1021617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021617 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021617 Vd NA 0.3811 L/kg 1compartment NA NA Human Human +DTXSID1021617 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1021617 TK.Half.Life NA 0.7797 hours 1compartment NA NA Human Human +DTXSID1021617 Css NA 0.1864 mg/L 3compartmentss NA 50% Human Human +DTXSID1021617 Css NA 1.523 mg/L 3compartmentss NA 95% Human Human +DTXSID1021617 Css NA 0.1216 mg/L PBTK NA 50% Human Human +DTXSID1021617 Css NA 0.9414 mg/L PBTK NA 95% Human Human +DTXSID1021617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021617 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021617 Vd NA 0.375 L/kg 1compartment NA NA Rat Human DTXSID1021617 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021617 TK.Half.Life NA 6.371 hours 1compartment NA NA Rat Human -DTXSID1021617 Css NA 2.332 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021617 Css NA 9.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021617 Css NA 1.397 mg/L PBTK NA 50% Rat Human -DTXSID1021617 Css NA 5.337 mg/L PBTK NA 95% Rat Human -DTXSID1021667 Clint NA 0.04461 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021667 Fup NA 0.675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021667 Vd NA 2.962 L/kg 1compartment NA NA Human Human -DTXSID1021667 Days.Css NA 31 Days PBTK NA NA Human Human -DTXSID1021667 TK.Half.Life NA 159.8 hours 1compartment NA NA Human Human -DTXSID1021667 Css NA 5.68 mg/L 3compartmentss NA 50% Human Human -DTXSID1021667 Css NA 18.9 mg/L 3compartmentss NA 95% Human Human -DTXSID1021667 Css NA 4.451 mg/L PBTK NA 50% Human Human -DTXSID1021667 Css NA 12.98 mg/L PBTK NA 95% Human Human -DTXSID1021667 Clint NA 0.04461 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021667 Fup NA 0.675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021667 Vd NA 2.279 L/kg 1compartment NA NA Rat Human -DTXSID1021667 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID1021667 TK.Half.Life NA 15.87 hours 1compartment NA NA Rat Human -DTXSID1021667 Css NA 1.631 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021667 Css NA 4.548 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021667 Css NA 1.228 mg/L PBTK NA 50% Rat Human -DTXSID1021667 Css NA 2.87 mg/L PBTK NA 95% Rat Human -DTXSID1021740 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021740 Fup NA 0.827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021740 Vd NA 1.154 L/kg 1compartment NA NA Human Human +DTXSID1021617 TK.Half.Life NA 0.4423 hours 1compartment NA NA Rat Human +DTXSID1021617 Css NA 0.02398 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021617 Css NA 0.1488 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021617 Css NA 0.01532 mg/L PBTK NA 50% Rat Human +DTXSID1021617 Css NA 0.0907 mg/L PBTK NA 95% Rat Human +DTXSID1021740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021740 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021740 Vd NA 0.723 L/kg 1compartment NA NA Human Human DTXSID1021740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021740 TK.Half.Life NA 9.441 hours 1compartment NA NA Human Human -DTXSID1021740 Css NA 0.9108 mg/L 3compartmentss NA 50% Human Human -DTXSID1021740 Css NA 5.785 mg/L 3compartmentss NA 95% Human Human -DTXSID1021740 Css NA 0.8121 mg/L PBTK NA 50% Human Human -DTXSID1021740 Css NA 3.852 mg/L PBTK NA 95% Human Human -DTXSID1021740 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021740 Fup NA 0.827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021740 Vd NA 1.094 L/kg 1compartment NA NA Rat Human +DTXSID1021740 TK.Half.Life NA 0.8359 hours 1compartment NA NA Human Human +DTXSID1021740 Css NA 0.04272 mg/L 3compartmentss NA 50% Human Human +DTXSID1021740 Css NA 0.3558 mg/L 3compartmentss NA 95% Human Human +DTXSID1021740 Css NA 0.03167 mg/L PBTK NA 50% Human Human +DTXSID1021740 Css NA 0.2371 mg/L PBTK NA 95% Human Human +DTXSID1021740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021740 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021740 Vd NA 0.681 L/kg 1compartment NA NA Rat Human DTXSID1021740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021740 TK.Half.Life NA 2.948 hours 1compartment NA NA Rat Human -DTXSID1021740 Css NA 0.233 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021740 Css NA 1.401 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021740 Css NA 0.2033 mg/L PBTK NA 50% Rat Human -DTXSID1021740 Css NA 0.8659 mg/L PBTK NA 95% Rat Human -DTXSID1021744 Clint NA 0.03077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021744 Fup NA 0.2455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021744 Vd NA 0.6329 L/kg 1compartment NA NA Human Human -DTXSID1021744 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1021744 TK.Half.Life NA 16.26 hours 1compartment NA NA Human Human -DTXSID1021744 Css NA 2.846 mg/L 3compartmentss NA 50% Human Human -DTXSID1021744 Css NA 11.22 mg/L 3compartmentss NA 95% Human Human -DTXSID1021744 Css NA 2.067 mg/L PBTK NA 50% Human Human -DTXSID1021744 Css NA 7.093 mg/L PBTK NA 95% Human Human -DTXSID1021744 Clint NA 0.03077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021744 Fup NA 0.2455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021744 Vd NA 0.5748 L/kg 1compartment NA NA Rat Human +DTXSID1021740 TK.Half.Life NA 0.4073 hours 1compartment NA NA Rat Human +DTXSID1021740 Css NA 0.001485 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021740 Css NA 0.01424 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021740 Css NA 0.001095 mg/L PBTK NA 50% Rat Human +DTXSID1021740 Css NA 0.009331 mg/L PBTK NA 95% Rat Human +DTXSID1021744 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021744 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021744 Vd NA 0.738 L/kg 1compartment NA NA Human Human +DTXSID1021744 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1021744 TK.Half.Life NA 0.9503 hours 1compartment NA NA Human Human +DTXSID1021744 Css NA 0.06682 mg/L 3compartmentss NA 50% Human Human +DTXSID1021744 Css NA 0.5037 mg/L 3compartmentss NA 95% Human Human +DTXSID1021744 Css NA 0.05027 mg/L PBTK NA 50% Human Human +DTXSID1021744 Css NA 0.3381 mg/L PBTK NA 95% Human Human +DTXSID1021744 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021744 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021744 Vd NA 0.6653 L/kg 1compartment NA NA Rat Human DTXSID1021744 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021744 TK.Half.Life NA 5.067 hours 1compartment NA NA Rat Human -DTXSID1021744 Css NA 0.8169 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021744 Css NA 2.776 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021744 Css NA 0.5641 mg/L PBTK NA 50% Rat Human -DTXSID1021744 Css NA 1.643 mg/L PBTK NA 95% Rat Human -DTXSID1021790 Clint NA 0.01956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021790 Fup NA 0.23 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021790 Vd NA 0.6138 L/kg 1compartment NA NA Human Human -DTXSID1021790 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1021790 TK.Half.Life NA 17.23 hours 1compartment NA NA Human Human -DTXSID1021790 Css NA 3.336 mg/L 3compartmentss NA 50% Human Human -DTXSID1021790 Css NA 12.55 mg/L 3compartmentss NA 95% Human Human -DTXSID1021790 Css NA 2.279 mg/L PBTK NA 50% Human Human -DTXSID1021790 Css NA 7.871 mg/L PBTK NA 95% Human Human -DTXSID1021790 Clint NA 0.01956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021790 Fup NA 0.23 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021790 Vd NA 0.5395 L/kg 1compartment NA NA Rat Human +DTXSID1021744 TK.Half.Life NA 0.4539 hours 1compartment NA NA Rat Human +DTXSID1021744 Css NA 0.008271 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021744 Css NA 0.04852 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021744 Css NA 0.006183 mg/L PBTK NA 50% Rat Human +DTXSID1021744 Css NA 0.03292 mg/L PBTK NA 95% Rat Human +DTXSID1021790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021790 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021790 Vd NA 0.6307 L/kg 1compartment NA NA Human Human +DTXSID1021790 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1021790 TK.Half.Life NA 0.9415 hours 1compartment NA NA Human Human +DTXSID1021790 Css NA 0.08676 mg/L 3compartmentss NA 50% Human Human +DTXSID1021790 Css NA 0.6402 mg/L 3compartmentss NA 95% Human Human +DTXSID1021790 Css NA 0.05964 mg/L PBTK NA 50% Human Human +DTXSID1021790 Css NA 0.4148 mg/L PBTK NA 95% Human Human +DTXSID1021790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021790 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021790 Vd NA 0.5543 L/kg 1compartment NA NA Rat Human DTXSID1021790 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021790 TK.Half.Life NA 5.127 hours 1compartment NA NA Rat Human -DTXSID1021790 Css NA 0.9502 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021790 Css NA 3.019 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021790 Css NA 0.6138 mg/L PBTK NA 50% Rat Human -DTXSID1021790 Css NA 1.741 mg/L PBTK NA 95% Rat Human -DTXSID1021792 Clint NA 8.921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021792 Fup NA 0.6331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021792 Vd NA 1.596 L/kg 1compartment NA NA Human Human +DTXSID1021790 TK.Half.Life NA 0.4438 hours 1compartment NA NA Rat Human +DTXSID1021790 Css NA 0.01125 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021790 Css NA 0.06008 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021790 Css NA 0.007602 mg/L PBTK NA 50% Rat Human +DTXSID1021790 Css NA 0.0391 mg/L PBTK NA 95% Rat Human +DTXSID1021792 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021792 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021792 Vd NA 1.066 L/kg 1compartment NA NA Human Human DTXSID1021792 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021792 TK.Half.Life NA 2.077 hours 1compartment NA NA Human Human -DTXSID1021792 Css NA 0.08456 mg/L 3compartmentss NA 50% Human Human -DTXSID1021792 Css NA 0.8153 mg/L 3compartmentss NA 95% Human Human -DTXSID1021792 Css NA 0.07332 mg/L PBTK NA 50% Human Human -DTXSID1021792 Css NA 0.5721 mg/L PBTK NA 95% Human Human -DTXSID1021792 Clint NA 8.921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021792 Fup NA 0.6331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021792 Vd NA 1.354 L/kg 1compartment NA NA Rat Human +DTXSID1021792 TK.Half.Life NA 1.418 hours 1compartment NA NA Human Human +DTXSID1021792 Css NA 0.07134 mg/L 3compartmentss NA 50% Human Human +DTXSID1021792 Css NA 0.5237 mg/L 3compartmentss NA 95% Human Human +DTXSID1021792 Css NA 0.0527 mg/L PBTK NA 50% Human Human +DTXSID1021792 Css NA 0.3597 mg/L PBTK NA 95% Human Human +DTXSID1021792 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021792 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021792 Vd NA 0.8965 L/kg 1compartment NA NA Rat Human DTXSID1021792 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021792 TK.Half.Life NA 0.8587 hours 1compartment NA NA Rat Human -DTXSID1021792 Css NA 0.04226 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021792 Css NA 0.3253 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021792 Css NA 0.03562 mg/L PBTK NA 50% Rat Human -DTXSID1021792 Css NA 0.2082 mg/L PBTK NA 95% Rat Human +DTXSID1021792 TK.Half.Life NA 0.6134 hours 1compartment NA NA Rat Human +DTXSID1021792 Css NA 0.008882 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021792 Css NA 0.05017 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021792 Css NA 0.006516 mg/L PBTK NA 50% Rat Human +DTXSID1021792 Css NA 0.03329 mg/L PBTK NA 95% Rat Human DTXSID1021798 Clint 38.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1021798 Fup 0.2036 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1021798 Vd NA 1.08 L/kg 1compartment NA NA Human Human DTXSID1021798 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1021798 TK.Half.Life NA 1.425 hours 1compartment NA NA Human Human -DTXSID1021798 Css NA 0.06866 mg/L 3compartmentss NA 50% Human Human -DTXSID1021798 Css NA 0.4753 mg/L 3compartmentss NA 95% Human Human -DTXSID1021798 Css NA 0.04672 mg/L PBTK NA 50% Human Human -DTXSID1021798 Css NA 0.3126 mg/L PBTK NA 95% Human Human +DTXSID1021798 Css NA 0.06354 mg/L 3compartmentss NA 50% Human Human +DTXSID1021798 Css NA 0.4755 mg/L 3compartmentss NA 95% Human Human +DTXSID1021798 Css NA 0.04356 mg/L PBTK NA 50% Human Human +DTXSID1021798 Css NA 0.3051 mg/L PBTK NA 95% Human Human DTXSID1021798 Clint 38.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1021798 Fup 0.2036 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1021798 Vd NA 0.8573 L/kg 1compartment NA NA Rat Human DTXSID1021798 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1021798 TK.Half.Life NA 0.5663 hours 1compartment NA NA Rat Human -DTXSID1021798 Css NA 0.03784 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021798 Css NA 0.2079 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021798 Css NA 0.02463 mg/L PBTK NA 50% Rat Human -DTXSID1021798 Css NA 0.1286 mg/L PBTK NA 95% Rat Human -DTXSID1021821 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021821 Fup NA 0.8706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021821 Vd NA 0.8404 L/kg 1compartment NA NA Human Human +DTXSID1021798 Css NA 0.008182 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021798 Css NA 0.04737 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021798 Css NA 0.005518 mg/L PBTK NA 50% Rat Human +DTXSID1021798 Css NA 0.0305 mg/L PBTK NA 95% Rat Human +DTXSID1021821 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021821 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021821 Vd NA 0.6244 L/kg 1compartment NA NA Human Human DTXSID1021821 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021821 TK.Half.Life NA 6.33 hours 1compartment NA NA Human Human -DTXSID1021821 Css NA 0.9454 mg/L 3compartmentss NA 50% Human Human -DTXSID1021821 Css NA 5.319 mg/L 3compartmentss NA 95% Human Human -DTXSID1021821 Css NA 0.7846 mg/L PBTK NA 50% Human Human -DTXSID1021821 Css NA 3.498 mg/L PBTK NA 95% Human Human -DTXSID1021821 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021821 Fup NA 0.8706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021821 Vd NA 0.8267 L/kg 1compartment NA NA Rat Human +DTXSID1021821 TK.Half.Life NA 7.728 hours 1compartment NA NA Human Human +DTXSID1021821 Css NA 1.212 mg/L 3compartmentss NA 50% Human Human +DTXSID1021821 Css NA 6.833 mg/L 3compartmentss NA 95% Human Human +DTXSID1021821 Css NA 0.9194 mg/L PBTK NA 50% Human Human +DTXSID1021821 Css NA 4.258 mg/L PBTK NA 95% Human Human +DTXSID1021821 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021821 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021821 Vd NA 0.6129 L/kg 1compartment NA NA Rat Human DTXSID1021821 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021821 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human -DTXSID1021821 Css NA 0.2411 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021821 Css NA 1.408 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021821 Css NA 0.1943 mg/L PBTK NA 50% Rat Human -DTXSID1021821 Css NA 0.8464 mg/L PBTK NA 95% Rat Human -DTXSID1021823 Clint NA 0.1927 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021823 Fup NA 0.4871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021823 Vd NA 1.143 L/kg 1compartment NA NA Human Human -DTXSID1021823 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1021823 TK.Half.Life NA 12.51 hours 1compartment NA NA Human Human -DTXSID1021823 Css NA 1.098 mg/L 3compartmentss NA 50% Human Human -DTXSID1021823 Css NA 5.706 mg/L 3compartmentss NA 95% Human Human -DTXSID1021823 Css NA 0.9014 mg/L PBTK NA 50% Human Human -DTXSID1021823 Css NA 3.752 mg/L PBTK NA 95% Human Human -DTXSID1021823 Clint NA 0.1927 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021823 Fup NA 0.4871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021823 Vd NA 1.012 L/kg 1compartment NA NA Rat Human +DTXSID1021821 TK.Half.Life NA 2.57 hours 1compartment NA NA Rat Human +DTXSID1021821 Css NA 0.02278 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021821 Css NA 0.1686 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021821 Css NA 0.01675 mg/L PBTK NA 50% Rat Human +DTXSID1021821 Css NA 0.1066 mg/L PBTK NA 95% Rat Human +DTXSID1021823 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021823 Fup 0.0765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021823 Vd NA 0.6043 L/kg 1compartment NA NA Human Human +DTXSID1021823 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1021823 TK.Half.Life NA 4.895 hours 1compartment NA NA Human Human +DTXSID1021823 Css NA 1.226 mg/L 3compartmentss NA 50% Human Human +DTXSID1021823 Css NA 8.241 mg/L 3compartmentss NA 95% Human Human +DTXSID1021823 Css NA 0.7622 mg/L PBTK NA 50% Human Human +DTXSID1021823 Css NA 4.878 mg/L PBTK NA 95% Human Human +DTXSID1021823 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021823 Fup 0.0765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021823 Vd NA 0.4972 L/kg 1compartment NA NA Rat Human DTXSID1021823 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021823 TK.Half.Life NA 4.042 hours 1compartment NA NA Rat Human -DTXSID1021823 Css NA 0.3393 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021823 Css NA 1.611 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021823 Css NA 0.2704 mg/L PBTK NA 50% Rat Human -DTXSID1021823 Css NA 0.9839 mg/L PBTK NA 95% Rat Human -DTXSID1021871 Clint NA 8.379 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1021823 TK.Half.Life NA 2.42 hours 1compartment NA NA Rat Human +DTXSID1021823 Css NA 0.1509 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021823 Css NA 0.741 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021823 Css NA 0.09117 mg/L PBTK NA 50% Rat Human +DTXSID1021823 Css NA 0.4289 mg/L PBTK NA 95% Rat Human +DTXSID1021871 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1021871 Fup 0.23 NA NA https://doi.org/10.1016/S0300-483X(02)00085-9 NA Human Human DTXSID1021871 Vd NA 1.639 L/kg 1compartment NA NA Human Human DTXSID1021871 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021871 TK.Half.Life NA 5.008 hours 1compartment NA NA Human Human -DTXSID1021871 Css NA 0.2858 mg/L 3compartmentss NA 50% Human Human -DTXSID1021871 Css NA 1.67 mg/L 3compartmentss NA 95% Human Human -DTXSID1021871 Css NA 0.2104 mg/L PBTK NA 50% Human Human -DTXSID1021871 Css NA 1.158 mg/L PBTK NA 95% Human Human -DTXSID1021871 Clint NA 8.379 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1021871 TK.Half.Life NA 2.749 hours 1compartment NA NA Human Human +DTXSID1021871 Css NA 0.1124 mg/L 3compartmentss NA 50% Human Human +DTXSID1021871 Css NA 0.7586 mg/L 3compartmentss NA 95% Human Human +DTXSID1021871 Css NA 0.08172 mg/L PBTK NA 50% Human Human +DTXSID1021871 Css NA 0.5138 mg/L PBTK NA 95% Human Human +DTXSID1021871 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1021871 Fup 0.23 NA NA https://doi.org/10.1016/S0300-483X(02)00085-9 NA Rat Human DTXSID1021871 Vd NA 1.291 L/kg 1compartment NA NA Rat Human DTXSID1021871 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021871 TK.Half.Life NA 1.918 hours 1compartment NA NA Rat Human -DTXSID1021871 Css NA 0.15 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021871 Css NA 0.6342 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021871 Css NA 0.106 mg/L PBTK NA 50% Rat Human -DTXSID1021871 Css NA 0.41 mg/L PBTK NA 95% Rat Human +DTXSID1021871 TK.Half.Life NA 1.044 hours 1compartment NA NA Rat Human +DTXSID1021871 Css NA 0.014 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021871 Css NA 0.07213 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021871 Css NA 0.01017 mg/L PBTK NA 50% Rat Human +DTXSID1021871 Css NA 0.0495 mg/L PBTK NA 95% Rat Human DTXSID1021877 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021877 Fup NA 0.8652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021877 Vd NA 0.8719 L/kg 1compartment NA NA Human Human DTXSID1021877 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1021877 TK.Half.Life NA 6.564 hours 1compartment NA NA Human Human -DTXSID1021877 Css NA 0.9186 mg/L 3compartmentss NA 50% Human Human -DTXSID1021877 Css NA 5.587 mg/L 3compartmentss NA 95% Human Human -DTXSID1021877 Css NA 0.7848 mg/L PBTK NA 50% Human Human -DTXSID1021877 Css NA 3.64 mg/L PBTK NA 95% Human Human +DTXSID1021877 Css NA 0.782 mg/L 3compartmentss NA 50% Human Human +DTXSID1021877 Css NA 4.778 mg/L 3compartmentss NA 95% Human Human +DTXSID1021877 Css NA 0.6634 mg/L PBTK NA 50% Human Human +DTXSID1021877 Css NA 3.095 mg/L PBTK NA 95% Human Human DTXSID1021877 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1021877 Fup NA 0.8652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1021877 Vd NA 0.8816 L/kg 1compartment NA NA Rat Human DTXSID1021877 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1021877 TK.Half.Life NA 2.25 hours 1compartment NA NA Rat Human -DTXSID1021877 Css NA 0.2359 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021877 Css NA 1.435 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021877 Css NA 0.1956 mg/L PBTK NA 50% Rat Human -DTXSID1021877 Css NA 0.8686 mg/L PBTK NA 95% Rat Human +DTXSID1021877 Css NA 0.01464 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021877 Css NA 0.1107 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021877 Css NA 0.01197 mg/L PBTK NA 50% Rat Human +DTXSID1021877 Css NA 0.07359 mg/L PBTK NA 95% Rat Human DTXSID1021904 Clint NA 0.3394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021904 Fup NA 0.7531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1021904 Vd NA 2.044 L/kg 1compartment NA NA Human Human DTXSID1021904 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1021904 TK.Half.Life NA 11.31 hours 1compartment NA NA Human Human -DTXSID1021904 Css NA 0.5012 mg/L 3compartmentss NA 50% Human Human -DTXSID1021904 Css NA 3.482 mg/L 3compartmentss NA 95% Human Human -DTXSID1021904 Css NA 0.5264 mg/L PBTK NA 50% Human Human -DTXSID1021904 Css NA 2.503 mg/L PBTK NA 95% Human Human +DTXSID1021904 Css NA 0.4244 mg/L 3compartmentss NA 50% Human Human +DTXSID1021904 Css NA 3.151 mg/L 3compartmentss NA 95% Human Human +DTXSID1021904 Css NA 0.4528 mg/L PBTK NA 50% Human Human +DTXSID1021904 Css NA 2.204 mg/L PBTK NA 95% Human Human DTXSID1021904 Clint NA 0.3394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1021904 Fup NA 0.7531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1021904 Vd NA 2.027 L/kg 1compartment NA NA Rat Human DTXSID1021904 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1021904 TK.Half.Life NA 4.668 hours 1compartment NA NA Rat Human -DTXSID1021904 Css NA 0.1577 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021904 Css NA 1.226 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021904 Css NA 0.1648 mg/L PBTK NA 50% Rat Human -DTXSID1021904 Css NA 0.7883 mg/L PBTK NA 95% Rat Human +DTXSID1021904 Css NA 0.009785 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021904 Css NA 0.09847 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021904 Css NA 0.01018 mg/L PBTK NA 50% Rat Human +DTXSID1021904 Css NA 0.06996 mg/L PBTK NA 95% Rat Human DTXSID1021952 Clint 26.44 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1021952 Fup 0.002852 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1021952 Vd NA 1.868 L/kg 1compartment NA NA Human Human DTXSID1021952 Days.Css NA 6 Days PBTK NA NA Human Human DTXSID1021952 TK.Half.Life NA 45.87 hours 1compartment NA NA Human Human -DTXSID1021952 Css NA 4.021 mg/L 3compartmentss NA 50% Human Human -DTXSID1021952 Css NA 30.62 mg/L 3compartmentss NA 95% Human Human -DTXSID1021952 Css NA 2.524 mg/L PBTK NA 50% Human Human -DTXSID1021952 Css NA 18.6 mg/L PBTK NA 95% Human Human +DTXSID1021952 Css NA 3.809 mg/L 3compartmentss NA 50% Human Human +DTXSID1021952 Css NA 31.05 mg/L 3compartmentss NA 95% Human Human +DTXSID1021952 Css NA 2.389 mg/L PBTK NA 50% Human Human +DTXSID1021952 Css NA 18.9 mg/L PBTK NA 95% Human Human DTXSID1021952 Clint 26.44 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1021952 Fup 0.002852 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1021952 Vd NA 1.377 L/kg 1compartment NA NA Rat Human -DTXSID1021952 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID1021952 TK.Half.Life NA 15.53 hours 1compartment NA NA Rat Human -DTXSID1021952 Css NA 2.326 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021952 Css NA 14.35 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021952 Css NA 1.37 mg/L PBTK NA 50% Rat Human -DTXSID1021952 Css NA 8.191 mg/L PBTK NA 95% Rat Human +DTXSID1021952 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1021952 TK.Half.Life NA 3.717 hours 1compartment NA NA Rat Human +DTXSID1021952 Css NA 0.08542 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021952 Css NA 0.6175 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021952 Css NA 0.05214 mg/L PBTK NA 50% Rat Human +DTXSID1021952 Css NA 0.3635 mg/L PBTK NA 95% Rat Human DTXSID1021956 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1021956 Fup 0.0233 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1021956 Vd NA 118.6 L/kg 1compartment NA NA Human Human DTXSID1021956 Days.Css NA 5901 Days PBTK NA NA Human Human DTXSID1021956 TK.Half.Life NA 5635000 hours 1compartment NA NA Human Human -DTXSID1021956 Css NA 248.1 mg/L 3compartmentss NA 50% Human Human -DTXSID1021956 Css NA 656.1 mg/L 3compartmentss NA 95% Human Human -DTXSID1021956 Css NA 3656 mg/L PBTK NA 50% Human Human -DTXSID1021956 Css NA 7835 mg/L PBTK NA 95% Human Human +DTXSID1021956 Css NA 240 mg/L 3compartmentss NA 50% Human Human +DTXSID1021956 Css NA 633.1 mg/L 3compartmentss NA 95% Human Human +DTXSID1021956 Css NA 3544 mg/L PBTK NA 50% Human Human +DTXSID1021956 Css NA 7703 mg/L PBTK NA 95% Human Human DTXSID1021956 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1021956 Fup 0.0233 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1021956 Vd NA 103.1 L/kg 1compartment NA NA Rat Human -DTXSID1021956 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID1021956 Days.Css NA 3276 Days PBTK NA NA Rat Human DTXSID1021956 TK.Half.Life NA 405300 hours 1compartment NA NA Rat Human -DTXSID1021956 Css NA 60.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021956 Css NA 109.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021956 Css NA 978.1 mg/L PBTK NA 50% Rat Human -DTXSID1021956 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID1021958 Clint NA 34.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021958 Fup NA 0.1958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1021958 Vd NA 2.271 L/kg 1compartment NA NA Human Human +DTXSID1021956 Css NA 13.49 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021956 Css NA 24.72 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021956 Css NA 228 mg/L PBTK NA 50% Rat Human +DTXSID1021956 Css NA 311.1 mg/L PBTK NA 95% Rat Human +DTXSID1021958 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021958 Fup 0.0907 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1021958 Vd NA 1.737 L/kg 1compartment NA NA Human Human DTXSID1021958 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1021958 TK.Half.Life NA 4.03 hours 1compartment NA NA Human Human -DTXSID1021958 Css NA 0.1239 mg/L 3compartmentss NA 50% Human Human -DTXSID1021958 Css NA 0.8027 mg/L 3compartmentss NA 95% Human Human -DTXSID1021958 Css NA 0.0897 mg/L PBTK NA 50% Human Human -DTXSID1021958 Css NA 0.5503 mg/L PBTK NA 95% Human Human -DTXSID1021958 Clint NA 34.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021958 Fup NA 0.1958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1021958 Vd NA 1.738 L/kg 1compartment NA NA Rat Human +DTXSID1021958 TK.Half.Life NA 5.631 hours 1compartment NA NA Human Human +DTXSID1021958 Css NA 0.3664 mg/L 3compartmentss NA 50% Human Human +DTXSID1021958 Css NA 2.624 mg/L 3compartmentss NA 95% Human Human +DTXSID1021958 Css NA 0.2428 mg/L PBTK NA 50% Human Human +DTXSID1021958 Css NA 1.67 mg/L PBTK NA 95% Human Human +DTXSID1021958 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021958 Fup 0.0907 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1021958 Vd NA 1.318 L/kg 1compartment NA NA Rat Human DTXSID1021958 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1021958 TK.Half.Life NA 1.263 hours 1compartment NA NA Rat Human -DTXSID1021958 Css NA 0.0686 mg/L 3compartmentss NA 50% Rat Human -DTXSID1021958 Css NA 0.3495 mg/L 3compartmentss NA 95% Rat Human -DTXSID1021958 Css NA 0.04789 mg/L PBTK NA 50% Rat Human -DTXSID1021958 Css NA 0.2364 mg/L PBTK NA 95% Rat Human -DTXSID1022009 Clint NA 81.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022009 Fup NA 0.1505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022009 Vd NA 4.49 L/kg 1compartment NA NA Human Human +DTXSID1021958 TK.Half.Life NA 2.036 hours 1compartment NA NA Rat Human +DTXSID1021958 Css NA 0.0472 mg/L 3compartmentss NA 50% Rat Human +DTXSID1021958 Css NA 0.2674 mg/L 3compartmentss NA 95% Rat Human +DTXSID1021958 Css NA 0.03084 mg/L PBTK NA 50% Rat Human +DTXSID1021958 Css NA 0.166 mg/L PBTK NA 95% Rat Human +DTXSID1022009 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022009 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022009 Vd NA 5.099 L/kg 1compartment NA NA Human Human DTXSID1022009 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022009 TK.Half.Life NA 1.728 hours 1compartment NA NA Human Human -DTXSID1022009 Css NA 0.00182 mg/L 3compartmentss NA 50% Human Human -DTXSID1022009 Css NA 0.01883 mg/L 3compartmentss NA 95% Human Human -DTXSID1022009 Css NA 0.002593 mg/L PBTK NA 50% Human Human -DTXSID1022009 Css NA 0.01955 mg/L PBTK NA 95% Human Human -DTXSID1022009 Clint NA 81.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022009 Fup NA 0.1505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022009 Vd NA 4.268 L/kg 1compartment NA NA Rat Human +DTXSID1022009 TK.Half.Life NA 2.055 hours 1compartment NA NA Human Human +DTXSID1022009 Css NA 0.00367 mg/L 3compartmentss NA 50% Human Human +DTXSID1022009 Css NA 0.03765 mg/L 3compartmentss NA 95% Human Human +DTXSID1022009 Css NA 0.005997 mg/L PBTK NA 50% Human Human +DTXSID1022009 Css NA 0.04922 mg/L PBTK NA 95% Human Human +DTXSID1022009 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022009 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022009 Vd NA 4.869 L/kg 1compartment NA NA Rat Human DTXSID1022009 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022009 TK.Half.Life NA 0.7308 hours 1compartment NA NA Rat Human -DTXSID1022009 Css NA 0.000991 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022009 Css NA 0.008797 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022009 Css NA 0.001408 mg/L PBTK NA 50% Rat Human -DTXSID1022009 Css NA 0.008613 mg/L PBTK NA 95% Rat Human -DTXSID1022051 Clint NA 3.214 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022051 Fup NA 0.6069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022051 Vd NA 2.244 L/kg 1compartment NA NA Human Human +DTXSID1022009 TK.Half.Life NA 0.8938 hours 1compartment NA NA Rat Human +DTXSID1022009 Css NA 0.0004622 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022009 Css NA 0.003753 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022009 Css NA 0.0008189 mg/L PBTK NA 50% Rat Human +DTXSID1022009 Css NA 0.005314 mg/L PBTK NA 95% Rat Human +DTXSID1022051 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022051 Fup 0.181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022051 Vd NA 1.319 L/kg 1compartment NA NA Human Human DTXSID1022051 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022051 TK.Half.Life NA 7.309 hours 1compartment NA NA Human Human -DTXSID1022051 Css NA 0.3031 mg/L 3compartmentss NA 50% Human Human -DTXSID1022051 Css NA 1.988 mg/L 3compartmentss NA 95% Human Human -DTXSID1022051 Css NA 0.2589 mg/L PBTK NA 50% Human Human -DTXSID1022051 Css NA 1.4 mg/L PBTK NA 95% Human Human -DTXSID1022051 Clint NA 3.214 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022051 Fup NA 0.6069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022051 Vd NA 1.807 L/kg 1compartment NA NA Rat Human +DTXSID1022051 TK.Half.Life NA 2.431 hours 1compartment NA NA Human Human +DTXSID1022051 Css NA 0.1316 mg/L 3compartmentss NA 50% Human Human +DTXSID1022051 Css NA 0.9246 mg/L 3compartmentss NA 95% Human Human +DTXSID1022051 Css NA 0.0924 mg/L PBTK NA 50% Human Human +DTXSID1022051 Css NA 0.6174 mg/L PBTK NA 95% Human Human +DTXSID1022051 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022051 Fup 0.181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022051 Vd NA 1.047 L/kg 1compartment NA NA Rat Human DTXSID1022051 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022051 TK.Half.Life NA 2.299 hours 1compartment NA NA Rat Human -DTXSID1022051 Css NA 0.1426 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022051 Css NA 0.7534 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022051 Css NA 0.1189 mg/L PBTK NA 50% Rat Human -DTXSID1022051 Css NA 0.4872 mg/L PBTK NA 95% Rat Human +DTXSID1022051 TK.Half.Life NA 0.9916 hours 1compartment NA NA Rat Human +DTXSID1022051 Css NA 0.01645 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022051 Css NA 0.08634 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022051 Css NA 0.01151 mg/L PBTK NA 50% Rat Human +DTXSID1022051 Css NA 0.05721 mg/L PBTK NA 95% Rat Human DTXSID1022053 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1022053 Fup 0.002637 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1022053 Vd NA 0.1792 L/kg 1compartment NA NA Human Human DTXSID1022053 Days.Css NA 112 Days PBTK NA NA Human Human DTXSID1022053 TK.Half.Life NA 439.8 hours 1compartment NA NA Human Human -DTXSID1022053 Css NA 435.4 mg/L 3compartmentss NA 50% Human Human -DTXSID1022053 Css NA 1992 mg/L 3compartmentss NA 95% Human Human -DTXSID1022053 Css NA 253.6 mg/L PBTK NA 50% Human Human -DTXSID1022053 Css NA 1151 mg/L PBTK NA 95% Human Human +DTXSID1022053 Css NA 423.5 mg/L 3compartmentss NA 50% Human Human +DTXSID1022053 Css NA 1910 mg/L 3compartmentss NA 95% Human Human +DTXSID1022053 Css NA 246.2 mg/L PBTK NA 50% Human Human +DTXSID1022053 Css NA 1095 mg/L PBTK NA 95% Human Human DTXSID1022053 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1022053 Fup 0.023 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1022053 Vd NA 0.283 L/kg 1compartment NA NA Rat Rat DTXSID1022053 Days.Css NA 4 Days PBTK NA NA Rat Rat DTXSID1022053 TK.Half.Life NA 27.13 hours 1compartment NA NA Rat Rat -DTXSID1022053 Css NA 13.27 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1022053 Css NA 70.43 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1022053 Css NA 7.6 mg/L PBTK NA 50% Rat Rat -DTXSID1022053 Css NA 38.48 mg/L PBTK NA 95% Rat Rat -DTXSID1022138 Clint NA 0.2877 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022138 Fup NA 0.7473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022138 Vd NA 1.286 L/kg 1compartment NA NA Human Human +DTXSID1022053 Css NA 2.958 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1022053 Css NA 15.86 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1022053 Css NA 1.754 mg/L PBTK NA 50% Rat Rat +DTXSID1022053 Css NA 8.976 mg/L PBTK NA 95% Rat Rat +DTXSID1022130 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022130 Fup 0.076 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022130 Vd NA 1.482 L/kg 1compartment NA NA Human Human +DTXSID1022130 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1022130 TK.Half.Life NA 5.104 hours 1compartment NA NA Human Human +DTXSID1022130 Css NA 0.4092 mg/L 3compartmentss NA 50% Human Human +DTXSID1022130 Css NA 2.959 mg/L 3compartmentss NA 95% Human Human +DTXSID1022130 Css NA 0.2668 mg/L PBTK NA 50% Human Human +DTXSID1022130 Css NA 1.844 mg/L PBTK NA 95% Human Human +DTXSID1022130 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022130 Fup 0.076 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022130 Vd NA 1.126 L/kg 1compartment NA NA Rat Human +DTXSID1022130 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1022130 TK.Half.Life NA 1.984 hours 1compartment NA NA Rat Human +DTXSID1022130 Css NA 0.0533 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022130 Css NA 0.3023 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022130 Css NA 0.03391 mg/L PBTK NA 50% Rat Human +DTXSID1022130 Css NA 0.185 mg/L PBTK NA 95% Rat Human +DTXSID1022138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022138 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022138 Vd NA 1.121 L/kg 1compartment NA NA Human Human DTXSID1022138 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022138 TK.Half.Life NA 8.208 hours 1compartment NA NA Human Human -DTXSID1022138 Css NA 0.6479 mg/L 3compartmentss NA 50% Human Human -DTXSID1022138 Css NA 4.313 mg/L 3compartmentss NA 95% Human Human -DTXSID1022138 Css NA 0.5834 mg/L PBTK NA 50% Human Human -DTXSID1022138 Css NA 2.845 mg/L PBTK NA 95% Human Human -DTXSID1022138 Clint NA 0.2877 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022138 Fup NA 0.7473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022138 Vd NA 1.174 L/kg 1compartment NA NA Rat Human +DTXSID1022138 TK.Half.Life NA 1.083 hours 1compartment NA NA Human Human +DTXSID1022138 Css NA 0.03032 mg/L 3compartmentss NA 50% Human Human +DTXSID1022138 Css NA 0.3001 mg/L 3compartmentss NA 95% Human Human +DTXSID1022138 Css NA 0.02482 mg/L PBTK NA 50% Human Human +DTXSID1022138 Css NA 0.2106 mg/L PBTK NA 95% Human Human +DTXSID1022138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022138 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022138 Vd NA 1.003 L/kg 1compartment NA NA Rat Human DTXSID1022138 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022138 TK.Half.Life NA 2.869 hours 1compartment NA NA Rat Human -DTXSID1022138 Css NA 0.203 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022138 Css NA 1.347 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022138 Css NA 0.1785 mg/L PBTK NA 50% Rat Human -DTXSID1022138 Css NA 0.8271 mg/L PBTK NA 95% Rat Human -DTXSID1022180 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022180 Fup NA 0.2199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022180 Vd NA 2.753 L/kg 1compartment NA NA Human Human -DTXSID1022180 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1022180 TK.Half.Life NA 34.64 hours 1compartment NA NA Human Human -DTXSID1022180 Css NA 1.436 mg/L 3compartmentss NA 50% Human Human -DTXSID1022180 Css NA 6.845 mg/L 3compartmentss NA 95% Human Human -DTXSID1022180 Css NA 1.034 mg/L PBTK NA 50% Human Human -DTXSID1022180 Css NA 4.713 mg/L PBTK NA 95% Human Human -DTXSID1022180 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022180 Fup NA 0.2199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022180 Vd NA 2.089 L/kg 1compartment NA NA Rat Human -DTXSID1022180 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1022180 TK.Half.Life NA 6.999 hours 1compartment NA NA Rat Human -DTXSID1022180 Css NA 0.7258 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022180 Css NA 2.481 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022180 Css NA 0.5042 mg/L PBTK NA 50% Rat Human -DTXSID1022180 Css NA 1.629 mg/L PBTK NA 95% Rat Human -DTXSID1022217 Clint NA 605.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022217 Fup NA 0.5101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022217 Vd NA 1.166 L/kg 1compartment NA NA Human Human +DTXSID1022138 TK.Half.Life NA 0.4807 hours 1compartment NA NA Rat Human +DTXSID1022138 Css NA 0.001053 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022138 Css NA 0.01258 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022138 Css NA 0.0008489 mg/L PBTK NA 50% Rat Human +DTXSID1022138 Css NA 0.008718 mg/L PBTK NA 95% Rat Human +DTXSID1022186 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022186 Fup 0.602 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022186 Vd NA 1.675 L/kg 1compartment NA NA Human Human +DTXSID1022186 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1022186 TK.Half.Life NA 1.551 hours 1compartment NA NA Human Human +DTXSID1022186 Css NA 0.03605 mg/L 3compartmentss NA 50% Human Human +DTXSID1022186 Css NA 0.383 mg/L 3compartmentss NA 95% Human Human +DTXSID1022186 Css NA 0.031 mg/L PBTK NA 50% Human Human +DTXSID1022186 Css NA 0.2726 mg/L PBTK NA 95% Human Human +DTXSID1022186 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022186 Fup 0.602 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022186 Vd NA 1.416 L/kg 1compartment NA NA Rat Human +DTXSID1022186 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1022186 TK.Half.Life NA 0.615 hours 1compartment NA NA Rat Human +DTXSID1022186 Css NA 0.00437 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022186 Css NA 0.03741 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022186 Css NA 0.003862 mg/L PBTK NA 50% Rat Human +DTXSID1022186 Css NA 0.02703 mg/L PBTK NA 95% Rat Human +DTXSID1022217 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022217 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022217 Vd NA 0.9274 L/kg 1compartment NA NA Human Human DTXSID1022217 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022217 TK.Half.Life NA 0.7625 hours 1compartment NA NA Human Human -DTXSID1022217 Css NA 0.001513 mg/L 3compartmentss NA 50% Human Human -DTXSID1022217 Css NA 0.01418 mg/L 3compartmentss NA 95% Human Human -DTXSID1022217 Css NA 0.001233 mg/L PBTK NA 50% Human Human -DTXSID1022217 Css NA 0.01015 mg/L PBTK NA 95% Human Human -DTXSID1022217 Clint NA 605.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022217 Fup NA 0.5101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022217 Vd NA 1.034 L/kg 1compartment NA NA Rat Human +DTXSID1022217 TK.Half.Life NA 1.126 hours 1compartment NA NA Human Human +DTXSID1022217 Css NA 0.05803 mg/L 3compartmentss NA 50% Human Human +DTXSID1022217 Css NA 0.4376 mg/L 3compartmentss NA 95% Human Human +DTXSID1022217 Css NA 0.04347 mg/L PBTK NA 50% Human Human +DTXSID1022217 Css NA 0.3034 mg/L PBTK NA 95% Human Human +DTXSID1022217 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022217 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022217 Vd NA 0.8191 L/kg 1compartment NA NA Rat Human DTXSID1022217 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022217 TK.Half.Life NA 0.2941 hours 1compartment NA NA Rat Human -DTXSID1022217 Css NA 0.000814 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022217 Css NA 0.00656 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022217 Css NA 0.0006495 mg/L PBTK NA 50% Rat Human -DTXSID1022217 Css NA 0.004585 mg/L PBTK NA 95% Rat Human +DTXSID1022217 TK.Half.Life NA 0.5134 hours 1compartment NA NA Rat Human +DTXSID1022217 Css NA 0.007283 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022217 Css NA 0.0426 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022217 Css NA 0.005468 mg/L PBTK NA 50% Rat Human +DTXSID1022217 Css NA 0.0291 mg/L PBTK NA 95% Rat Human DTXSID1022265 Clint 62.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1022265 Fup 0.1332 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1022265 Vd NA 2.694 L/kg 1compartment NA NA Human Human DTXSID1022265 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1022265 TK.Half.Life NA 5.119 hours 1compartment NA NA Human Human -DTXSID1022265 Css NA 0.184 mg/L 3compartmentss NA 50% Human Human -DTXSID1022265 Css NA 1.158 mg/L 3compartmentss NA 95% Human Human -DTXSID1022265 Css NA 0.1178 mg/L PBTK NA 50% Human Human -DTXSID1022265 Css NA 0.7284 mg/L PBTK NA 95% Human Human +DTXSID1022265 Css NA 0.1322 mg/L 3compartmentss NA 50% Human Human +DTXSID1022265 Css NA 0.8667 mg/L 3compartmentss NA 95% Human Human +DTXSID1022265 Css NA 0.1128 mg/L PBTK NA 50% Human Human +DTXSID1022265 Css NA 0.7392 mg/L PBTK NA 95% Human Human DTXSID1022265 Clint 41.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID1022265 Fup 0.5973 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID1022265 Vd NA 2.337 L/kg 1compartment NA NA Rat Rat +DTXSID1022265 Vd 9.6 2.337 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID1022265 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID1022265 TK.Half.Life NA 1.356 hours 1compartment NA NA Rat Rat -DTXSID1022265 Css NA 0.1291 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1022265 Css NA 0.6707 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1022265 Css NA 0.07226 mg/L PBTK NA 50% Rat Rat -DTXSID1022265 Css NA 0.3699 mg/L PBTK NA 95% Rat Rat +DTXSID1022265 TK.Half.Life 0.061 1.356 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID1022265 Css 0.00038 0.01896 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID1022265 Css 0.00038 0.1003 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID1022265 Css 0.00038 0.01675 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID1022265 Css 0.00038 0.08861 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID1022267 Clint 2.05 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1022267 Fup 0.716 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1022267 Vd NA 0.9301 L/kg 1compartment NA NA Human Human DTXSID1022267 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1022267 TK.Half.Life NA 2.276 hours 1compartment NA NA Human Human -DTXSID1022267 Css NA 0.2026 mg/L 3compartmentss NA 50% Human Human -DTXSID1022267 Css NA 0.8153 mg/L 3compartmentss NA 95% Human Human -DTXSID1022267 Css NA 0.1758 mg/L PBTK NA 50% Human Human -DTXSID1022267 Css NA 0.6351 mg/L PBTK NA 95% Human Human +DTXSID1022267 Css NA 0.1947 mg/L 3compartmentss NA 50% Human Human +DTXSID1022267 Css NA 0.7965 mg/L 3compartmentss NA 95% Human Human +DTXSID1022267 Css NA 0.168 mg/L PBTK NA 50% Human Human +DTXSID1022267 Css NA 0.614 mg/L PBTK NA 95% Human Human DTXSID1022267 Clint 2.05 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1022267 Fup 0.716 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1022267 Vd NA 0.9051 L/kg 1compartment NA NA Rat Human DTXSID1022267 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1022267 TK.Half.Life NA 1.146 hours 1compartment NA NA Rat Human -DTXSID1022267 Css NA 0.08671 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022267 Css NA 0.2578 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022267 Css NA 0.07459 mg/L PBTK NA 50% Rat Human -DTXSID1022267 Css NA 0.1877 mg/L PBTK NA 95% Rat Human +DTXSID1022267 Css NA 0.01954 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022267 Css NA 0.05702 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022267 Css NA 0.01741 mg/L PBTK NA 50% Rat Human +DTXSID1022267 Css NA 0.04355 mg/L PBTK NA 95% Rat Human +DTXSID1022392 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022392 Fup 0.0605 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022392 Vd NA 0.9163 L/kg 1compartment NA NA Human Human +DTXSID1022392 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1022392 TK.Half.Life NA 3.431 hours 1compartment NA NA Human Human +DTXSID1022392 Css NA 0.4824 mg/L 3compartmentss NA 50% Human Human +DTXSID1022392 Css NA 3.756 mg/L 3compartmentss NA 95% Human Human +DTXSID1022392 Css NA 0.3032 mg/L PBTK NA 50% Human Human +DTXSID1022392 Css NA 2.297 mg/L PBTK NA 95% Human Human +DTXSID1022392 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022392 Fup 0.0605 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022392 Vd NA 0.7078 L/kg 1compartment NA NA Rat Human +DTXSID1022392 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1022392 TK.Half.Life NA 1.53 hours 1compartment NA NA Rat Human +DTXSID1022392 Css NA 0.06366 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022392 Css NA 0.3742 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022392 Css NA 0.03872 mg/L PBTK NA 50% Rat Human +DTXSID1022392 Css NA 0.2187 mg/L PBTK NA 95% Rat Human DTXSID1022394 Clint 230 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1022394 Fup 0.0203 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1022394 Vd NA 1.05 L/kg 1compartment NA NA Human Human +DTXSID1022394 Vd NA 0.7141 L/kg 1compartment NA NA Human Human DTXSID1022394 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022394 TK.Half.Life NA 1.766 hours 1compartment NA NA Human Human -DTXSID1022394 Css NA 0.1049 mg/L 3compartmentss NA 50% Human Human -DTXSID1022394 Css NA 0.8213 mg/L 3compartmentss NA 95% Human Human -DTXSID1022394 Css NA 0.06534 mg/L PBTK NA 50% Human Human -DTXSID1022394 Css NA 0.4972 mg/L PBTK NA 95% Human Human +DTXSID1022394 TK.Half.Life NA 1.213 hours 1compartment NA NA Human Human +DTXSID1022394 Css NA 0.09914 mg/L 3compartmentss NA 50% Human Human +DTXSID1022394 Css NA 0.8385 mg/L 3compartmentss NA 95% Human Human +DTXSID1022394 Css NA 0.05992 mg/L PBTK NA 50% Human Human +DTXSID1022394 Css NA 0.4951 mg/L PBTK NA 95% Human Human DTXSID1022394 Clint 230 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1022394 Fup 0.0203 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1022394 Vd NA 0.7824 L/kg 1compartment NA NA Rat Human +DTXSID1022394 Vd NA 0.5409 L/kg 1compartment NA NA Rat Human DTXSID1022394 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022394 TK.Half.Life NA 0.6789 hours 1compartment NA NA Rat Human -DTXSID1022394 Css NA 0.05994 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022394 Css NA 0.3738 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022394 Css NA 0.03489 mg/L PBTK NA 50% Rat Human -DTXSID1022394 Css NA 0.2109 mg/L PBTK NA 95% Rat Human +DTXSID1022394 TK.Half.Life NA 0.4919 hours 1compartment NA NA Rat Human +DTXSID1022394 Css NA 0.0129 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022394 Css NA 0.08883 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022394 Css NA 0.007608 mg/L PBTK NA 50% Rat Human +DTXSID1022394 Css NA 0.05195 mg/L PBTK NA 95% Rat Human DTXSID1022396 Clint 204 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1022396 Fup 0.00263 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1022396 Vd NA 0.3145 L/kg 1compartment NA NA Human Human +DTXSID1022396 Vd NA 0.4022 L/kg 1compartment NA NA Human Human DTXSID1022396 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022396 TK.Half.Life NA 2.197 hours 1compartment NA NA Human Human -DTXSID1022396 Css NA 1.116 mg/L 3compartmentss NA 50% Human Human -DTXSID1022396 Css NA 10.95 mg/L 3compartmentss NA 95% Human Human -DTXSID1022396 Css NA 0.6472 mg/L PBTK NA 50% Human Human -DTXSID1022396 Css NA 6.309 mg/L PBTK NA 95% Human Human +DTXSID1022396 TK.Half.Life NA 2.65 hours 1compartment NA NA Human Human +DTXSID1022396 Css NA 1.014 mg/L 3compartmentss NA 50% Human Human +DTXSID1022396 Css NA 10.34 mg/L 3compartmentss NA 95% Human Human +DTXSID1022396 Css NA 0.5964 mg/L PBTK NA 50% Human Human +DTXSID1022396 Css NA 6.031 mg/L PBTK NA 95% Human Human DTXSID1022396 Clint 204 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1022396 Fup 0.00263 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1022396 Vd NA 0.2507 L/kg 1compartment NA NA Rat Human +DTXSID1022396 Vd NA 0.3085 L/kg 1compartment NA NA Rat Human DTXSID1022396 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022396 TK.Half.Life NA 1.151 hours 1compartment NA NA Rat Human -DTXSID1022396 Css NA 0.651 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022396 Css NA 5.543 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022396 Css NA 0.3539 mg/L PBTK NA 50% Rat Human -DTXSID1022396 Css NA 3.007 mg/L PBTK NA 95% Rat Human +DTXSID1022396 TK.Half.Life NA 1.321 hours 1compartment NA NA Rat Human +DTXSID1022396 Css NA 0.137 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022396 Css NA 1.165 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022396 Css NA 0.07733 mg/L PBTK NA 50% Rat Human +DTXSID1022396 Css NA 0.654 mg/L PBTK NA 95% Rat Human DTXSID1022421 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1022421 Fup 0.498 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1022421 Vd NA 0.7502 L/kg 1compartment NA NA Human Human -DTXSID1022421 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1022421 TK.Half.Life NA 9.888 hours 1compartment NA NA Human Human -DTXSID1022421 Css NA 1.256 mg/L 3compartmentss NA 50% Human Human -DTXSID1022421 Css NA 3.904 mg/L 3compartmentss NA 95% Human Human -DTXSID1022421 Css NA 1.011 mg/L PBTK NA 50% Human Human -DTXSID1022421 Css NA 2.722 mg/L PBTK NA 95% Human Human +DTXSID1022421 Vd NA 3.061 L/kg 1compartment NA NA Human Human +DTXSID1022421 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1022421 TK.Half.Life NA 40.89 hours 1compartment NA NA Human Human +DTXSID1022421 Css NA 0.8276 mg/L 3compartmentss NA 50% Human Human +DTXSID1022421 Css NA 2.912 mg/L 3compartmentss NA 95% Human Human +DTXSID1022421 Css NA 0.9929 mg/L PBTK NA 50% Human Human +DTXSID1022421 Css NA 2.689 mg/L PBTK NA 95% Human Human DTXSID1022421 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1022421 Fup 0.498 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1022421 Vd NA 0.7275 L/kg 1compartment NA NA Rat Human -DTXSID1022421 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022421 TK.Half.Life NA 3.233 hours 1compartment NA NA Rat Human -DTXSID1022421 Css NA 0.3402 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022421 Css NA 0.8561 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022421 Css NA 0.2645 mg/L PBTK NA 50% Rat Human -DTXSID1022421 Css NA 0.5585 mg/L PBTK NA 95% Rat Human -DTXSID1022425 Clint NA 7.402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022425 Fup NA 0.0852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022425 Vd NA 1.32 L/kg 1compartment NA NA Human Human -DTXSID1022425 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022425 TK.Half.Life NA 9.396 hours 1compartment NA NA Human Human -DTXSID1022425 Css NA 1.021 mg/L 3compartmentss NA 50% Human Human -DTXSID1022425 Css NA 6.828 mg/L 3compartmentss NA 95% Human Human -DTXSID1022425 Css NA 0.6614 mg/L PBTK NA 50% Human Human -DTXSID1022425 Css NA 4.212 mg/L PBTK NA 95% Human Human -DTXSID1022425 Clint NA 7.402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022425 Fup NA 0.0852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022425 Vd NA 1.006 L/kg 1compartment NA NA Rat Human +DTXSID1022421 Vd NA 3.098 L/kg 1compartment NA NA Rat Human +DTXSID1022421 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1022421 TK.Half.Life NA 13.81 hours 1compartment NA NA Rat Human +DTXSID1022421 Css NA 0.05004 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022421 Css NA 0.1486 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022421 Css NA 0.06229 mg/L PBTK NA 50% Rat Human +DTXSID1022421 Css NA 0.1315 mg/L PBTK NA 95% Rat Human +DTXSID1022425 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022425 Fup 0.0322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022425 Vd NA 0.5582 L/kg 1compartment NA NA Human Human +DTXSID1022425 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1022425 TK.Half.Life NA 9.856 hours 1compartment NA NA Human Human +DTXSID1022425 Css NA 3.07 mg/L 3compartmentss NA 50% Human Human +DTXSID1022425 Css NA 24.22 mg/L 3compartmentss NA 95% Human Human +DTXSID1022425 Css NA 1.849 mg/L PBTK NA 50% Human Human +DTXSID1022425 Css NA 14.37 mg/L PBTK NA 95% Human Human +DTXSID1022425 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022425 Fup 0.0322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022425 Vd NA 0.4367 L/kg 1compartment NA NA Rat Human DTXSID1022425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022425 TK.Half.Life NA 3.771 hours 1compartment NA NA Rat Human -DTXSID1022425 Css NA 0.5512 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022425 Css NA 2.745 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022425 Css NA 0.3375 mg/L PBTK NA 50% Rat Human -DTXSID1022425 Css NA 1.574 mg/L PBTK NA 95% Rat Human -DTXSID1022479 Clint NA 7.786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022479 Fup NA 0.3465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022479 Vd NA 2.068 L/kg 1compartment NA NA Human Human +DTXSID1022425 TK.Half.Life NA 4.728 hours 1compartment NA NA Rat Human +DTXSID1022425 Css NA 0.3827 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022425 Css NA 2.394 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022425 Css NA 0.2222 mg/L PBTK NA 50% Rat Human +DTXSID1022425 Css NA 1.354 mg/L PBTK NA 95% Rat Human +DTXSID1022479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022479 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022479 Vd NA 1.544 L/kg 1compartment NA NA Human Human DTXSID1022479 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022479 TK.Half.Life NA 5.585 hours 1compartment NA NA Human Human -DTXSID1022479 Css NA 0.2372 mg/L 3compartmentss NA 50% Human Human -DTXSID1022479 Css NA 1.405 mg/L 3compartmentss NA 95% Human Human -DTXSID1022479 Css NA 0.185 mg/L PBTK NA 50% Human Human -DTXSID1022479 Css NA 1.006 mg/L PBTK NA 95% Human Human -DTXSID1022479 Clint NA 7.786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022479 Fup NA 0.3465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022479 Vd NA 1.628 L/kg 1compartment NA NA Rat Human +DTXSID1022479 TK.Half.Life NA 3.066 hours 1compartment NA NA Human Human +DTXSID1022479 Css NA 0.1482 mg/L 3compartmentss NA 50% Human Human +DTXSID1022479 Css NA 0.9949 mg/L 3compartmentss NA 95% Human Human +DTXSID1022479 Css NA 0.1048 mg/L PBTK NA 50% Human Human +DTXSID1022479 Css NA 0.6664 mg/L PBTK NA 95% Human Human +DTXSID1022479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022479 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022479 Vd NA 1.206 L/kg 1compartment NA NA Rat Human DTXSID1022479 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022479 TK.Half.Life NA 1.886 hours 1compartment NA NA Rat Human -DTXSID1022479 Css NA 0.1233 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022479 Css NA 0.5316 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022479 Css NA 0.09279 mg/L PBTK NA 50% Rat Human -DTXSID1022479 Css NA 0.3672 mg/L PBTK NA 95% Rat Human -DTXSID1022508 Clint NA 74.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022508 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022508 Vd NA 81.89 L/kg 1compartment NA NA Human Human -DTXSID1022508 Days.Css NA 164 Days PBTK NA NA Human Human -DTXSID1022508 TK.Half.Life NA 708 hours 1compartment NA NA Human Human -DTXSID1022508 Css NA 0.07426 mg/L 3compartmentss NA 50% Human Human -DTXSID1022508 Css NA 0.451 mg/L 3compartmentss NA 95% Human Human -DTXSID1022508 Css NA 0.716 mg/L PBTK NA 50% Human Human -DTXSID1022508 Css NA 4.03 mg/L PBTK NA 95% Human Human -DTXSID1022508 Clint NA 74.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022508 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022508 Vd NA 70.29 L/kg 1compartment NA NA Rat Human -DTXSID1022508 Days.Css NA 107 Days PBTK NA NA Rat Human -DTXSID1022508 TK.Half.Life NA 107.1 hours 1compartment NA NA Rat Human -DTXSID1022508 Css NA 0.03795 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022508 Css NA 0.1648 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022508 Css NA 0.3877 mg/L PBTK NA 50% Rat Human -DTXSID1022508 Css NA 1.641 mg/L PBTK NA 95% Rat Human -DTXSID1022556 Clint NA 4.008 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1022479 TK.Half.Life NA 1.184 hours 1compartment NA NA Rat Human +DTXSID1022479 Css NA 0.01867 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022479 Css NA 0.09661 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022479 Css NA 0.01304 mg/L PBTK NA 50% Rat Human +DTXSID1022479 Css NA 0.06424 mg/L PBTK NA 95% Rat Human +DTXSID1022556 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1022556 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1022556 Vd NA 0.8025 L/kg 1compartment NA NA Human Human +DTXSID1022556 Vd NA 0.8018 L/kg 1compartment NA NA Human Human DTXSID1022556 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022556 TK.Half.Life NA 1.091 hours 1compartment NA NA Human Human -DTXSID1022556 Css NA 0.03568 mg/L 3compartmentss NA 50% Human Human -DTXSID1022556 Css NA 0.2936 mg/L 3compartmentss NA 95% Human Human -DTXSID1022556 Css NA 0.0345 mg/L PBTK NA 50% Human Human -DTXSID1022556 Css NA 0.22 mg/L PBTK NA 95% Human Human -DTXSID1022556 Clint NA 4.008 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1022556 TK.Half.Life NA 6.102 hours 1compartment NA NA Human Human +DTXSID1022556 Css NA 0.6401 mg/L 3compartmentss NA 50% Human Human +DTXSID1022556 Css NA 3.063 mg/L 3compartmentss NA 95% Human Human +DTXSID1022556 Css NA 0.6913 mg/L PBTK NA 50% Human Human +DTXSID1022556 Css NA 3.308 mg/L PBTK NA 95% Human Human +DTXSID1022556 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1022556 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1022556 Vd NA 0.81 L/kg 1compartment NA NA Rat Human +DTXSID1022556 Vd NA 0.8094 L/kg 1compartment NA NA Rat Human DTXSID1022556 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022556 TK.Half.Life NA 0.595 hours 1compartment NA NA Rat Human -DTXSID1022556 Css NA 0.0503 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022556 Css NA 0.3569 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022556 Css NA 0.04903 mg/L PBTK NA 50% Rat Human -DTXSID1022556 Css NA 0.2411 mg/L PBTK NA 95% Rat Human -DTXSID1022558 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022558 Fup NA 0.8344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022558 Vd NA 0.7029 L/kg 1compartment NA NA Human Human +DTXSID1022556 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human +DTXSID1022556 Css NA 0.01482 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022556 Css NA 0.08133 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022556 Css NA 0.01622 mg/L PBTK NA 50% Rat Human +DTXSID1022556 Css NA 0.09025 mg/L PBTK NA 95% Rat Human +DTXSID1022558 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022558 Fup 0.774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022558 Vd NA 0.6721 L/kg 1compartment NA NA Human Human DTXSID1022558 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022558 TK.Half.Life NA 5.454 hours 1compartment NA NA Human Human -DTXSID1022558 Css NA 0.9858 mg/L 3compartmentss NA 50% Human Human -DTXSID1022558 Css NA 5.484 mg/L 3compartmentss NA 95% Human Human -DTXSID1022558 Css NA 0.803 mg/L PBTK NA 50% Human Human -DTXSID1022558 Css NA 3.527 mg/L PBTK NA 95% Human Human -DTXSID1022558 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022558 Fup NA 0.8344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022558 Vd NA 0.7358 L/kg 1compartment NA NA Rat Human +DTXSID1022558 TK.Half.Life NA 5.622 hours 1compartment NA NA Human Human +DTXSID1022558 Css NA 0.5651 mg/L 3compartmentss NA 50% Human Human +DTXSID1022558 Css NA 3.657 mg/L 3compartmentss NA 95% Human Human +DTXSID1022558 Css NA 0.4563 mg/L PBTK NA 50% Human Human +DTXSID1022558 Css NA 2.355 mg/L PBTK NA 95% Human Human +DTXSID1022558 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022558 Fup 0.774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022558 Vd NA 0.7035 L/kg 1compartment NA NA Rat Human DTXSID1022558 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022558 TK.Half.Life NA 1.944 hours 1compartment NA NA Rat Human -DTXSID1022558 Css NA 0.251 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022558 Css NA 1.466 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022558 Css NA 0.1984 mg/L PBTK NA 50% Rat Human -DTXSID1022558 Css NA 0.8748 mg/L PBTK NA 95% Rat Human -DTXSID1022635 Clint NA 0.225 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022635 Fup NA 0.4365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022635 Vd NA 0.4559 L/kg 1compartment NA NA Human Human +DTXSID1022558 TK.Half.Life NA 2.004 hours 1compartment NA NA Rat Human +DTXSID1022558 Css NA 0.002876 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022558 Css NA 0.02024 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022558 Css NA 0.002262 mg/L PBTK NA 50% Rat Human +DTXSID1022558 Css NA 0.01228 mg/L PBTK NA 95% Rat Human +DTXSID1022635 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022635 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022635 Vd NA 0.5787 L/kg 1compartment NA NA Human Human DTXSID1022635 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022635 TK.Half.Life NA 4.955 hours 1compartment NA NA Human Human -DTXSID1022635 Css NA 1.231 mg/L 3compartmentss NA 50% Human Human -DTXSID1022635 Css NA 5.613 mg/L 3compartmentss NA 95% Human Human -DTXSID1022635 Css NA 0.8776 mg/L PBTK NA 50% Human Human -DTXSID1022635 Css NA 3.507 mg/L PBTK NA 95% Human Human -DTXSID1022635 Clint NA 0.225 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022635 Fup NA 0.4365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022635 Vd NA 0.4656 L/kg 1compartment NA NA Rat Human +DTXSID1022635 TK.Half.Life NA 7.965 hours 1compartment NA NA Human Human +DTXSID1022635 Css NA 1.306 mg/L 3compartmentss NA 50% Human Human +DTXSID1022635 Css NA 6.405 mg/L 3compartmentss NA 95% Human Human +DTXSID1022635 Css NA 0.9917 mg/L PBTK NA 50% Human Human +DTXSID1022635 Css NA 4.057 mg/L PBTK NA 95% Human Human +DTXSID1022635 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022635 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022635 Vd NA 0.5888 L/kg 1compartment NA NA Rat Human DTXSID1022635 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022635 TK.Half.Life NA 1.996 hours 1compartment NA NA Rat Human -DTXSID1022635 Css NA 0.4016 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022635 Css NA 1.579 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022635 Css NA 0.2727 mg/L PBTK NA 50% Rat Human -DTXSID1022635 Css NA 0.9182 mg/L PBTK NA 95% Rat Human -DTXSID1022681 Clint NA 99.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022681 Fup NA 0.0192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022681 Vd NA 2.121 L/kg 1compartment NA NA Human Human -DTXSID1022681 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022681 TK.Half.Life NA 6.502 hours 1compartment NA NA Human Human -DTXSID1022681 Css NA 0.3618 mg/L 3compartmentss NA 50% Human Human -DTXSID1022681 Css NA 3.103 mg/L 3compartmentss NA 95% Human Human -DTXSID1022681 Css NA 0.2336 mg/L PBTK NA 50% Human Human -DTXSID1022681 Css NA 1.886 mg/L PBTK NA 95% Human Human -DTXSID1022681 Clint NA 99.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022681 Fup NA 0.0192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022681 Vd NA 1.578 L/kg 1compartment NA NA Rat Human -DTXSID1022681 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022681 TK.Half.Life NA 2.027 hours 1compartment NA NA Rat Human -DTXSID1022681 Css NA 0.2042 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022681 Css NA 1.392 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022681 Css NA 0.1244 mg/L PBTK NA 50% Rat Human -DTXSID1022681 Css NA 0.8103 mg/L PBTK NA 95% Rat Human -DTXSID1022683 Clint NA 31.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022683 Fup NA 0.0185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022683 Vd NA 1.933 L/kg 1compartment NA NA Human Human -DTXSID1022683 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022683 TK.Half.Life NA 5.177 hours 1compartment NA NA Human Human -DTXSID1022683 Css NA 0.3046 mg/L 3compartmentss NA 50% Human Human -DTXSID1022683 Css NA 3.074 mg/L 3compartmentss NA 95% Human Human -DTXSID1022683 Css NA 0.2104 mg/L PBTK NA 50% Human Human -DTXSID1022683 Css NA 1.936 mg/L PBTK NA 95% Human Human -DTXSID1022683 Clint NA 31.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022683 Fup NA 0.0185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022683 Vd NA 1.654 L/kg 1compartment NA NA Rat Human -DTXSID1022683 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022683 TK.Half.Life NA 2.351 hours 1compartment NA NA Rat Human -DTXSID1022683 Css NA 0.1699 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022683 Css NA 1.488 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022683 Css NA 0.1111 mg/L PBTK NA 50% Rat Human -DTXSID1022683 Css NA 0.9024 mg/L PBTK NA 95% Rat Human +DTXSID1022635 TK.Half.Life NA 2.757 hours 1compartment NA NA Rat Human +DTXSID1022635 Css NA 0.03231 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022635 Css NA 0.2027 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022635 Css NA 0.02421 mg/L PBTK NA 50% Rat Human +DTXSID1022635 Css NA 0.1296 mg/L PBTK NA 95% Rat Human +DTXSID1022639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022639 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1022639 Vd NA 0.6784 L/kg 1compartment NA NA Human Human +DTXSID1022639 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1022639 TK.Half.Life NA 0.9397 hours 1compartment NA NA Human Human +DTXSID1022639 Css NA 0.04898 mg/L 3compartmentss NA 50% Human Human +DTXSID1022639 Css NA 0.5557 mg/L 3compartmentss NA 95% Human Human +DTXSID1022639 Css NA 0.03979 mg/L PBTK NA 50% Human Human +DTXSID1022639 Css NA 0.3707 mg/L PBTK NA 95% Human Human +DTXSID1022639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022639 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1022639 Vd NA 0.6889 L/kg 1compartment NA NA Rat Human +DTXSID1022639 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1022639 TK.Half.Life NA 0.5134 hours 1compartment NA NA Rat Human +DTXSID1022639 Css NA 0.0004243 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022639 Css NA 0.004824 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022639 Css NA 0.0003423 mg/L PBTK NA 50% Rat Human +DTXSID1022639 Css NA 0.003045 mg/L PBTK NA 95% Rat Human +DTXSID1022681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022681 Fup 0.0056 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022681 Vd NA 1.865 L/kg 1compartment NA NA Human Human +DTXSID1022681 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1022681 TK.Half.Life NA 39.93 hours 1compartment NA NA Human Human +DTXSID1022681 Css NA 3.406 mg/L 3compartmentss NA 50% Human Human +DTXSID1022681 Css NA 28.9 mg/L 3compartmentss NA 95% Human Human +DTXSID1022681 Css NA 2.144 mg/L PBTK NA 50% Human Human +DTXSID1022681 Css NA 17.41 mg/L PBTK NA 95% Human Human +DTXSID1022681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022681 Fup 0.0056 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022681 Vd NA 1.377 L/kg 1compartment NA NA Rat Human +DTXSID1022681 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1022681 TK.Half.Life NA 13.51 hours 1compartment NA NA Rat Human +DTXSID1022681 Css NA 0.4436 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022681 Css NA 3.167 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022681 Css NA 0.2719 mg/L PBTK NA 50% Rat Human +DTXSID1022681 Css NA 1.885 mg/L PBTK NA 95% Rat Human +DTXSID1022683 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022683 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022683 Vd NA 3 L/kg 1compartment NA NA Human Human +DTXSID1022683 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID1022683 TK.Half.Life NA 63.01 hours 1compartment NA NA Human Human +DTXSID1022683 Css NA 2.571 mg/L 3compartmentss NA 50% Human Human +DTXSID1022683 Css NA 18.07 mg/L 3compartmentss NA 95% Human Human +DTXSID1022683 Css NA 1.766 mg/L PBTK NA 50% Human Human +DTXSID1022683 Css NA 12.1 mg/L PBTK NA 95% Human Human +DTXSID1022683 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022683 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022683 Vd NA 2.246 L/kg 1compartment NA NA Rat Human +DTXSID1022683 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID1022683 TK.Half.Life NA 9.986 hours 1compartment NA NA Rat Human +DTXSID1022683 Css NA 0.3368 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022683 Css NA 2.019 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022683 Css NA 0.2284 mg/L PBTK NA 50% Rat Human +DTXSID1022683 Css NA 1.321 mg/L PBTK NA 95% Rat Human DTXSID1022687 Clint 37 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID1022687 Fup 0.07 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human -DTXSID1022687 Vd NA 1.234 L/kg 1compartment NA NA Human Human +DTXSID1022687 Vd NA 2.345 L/kg 1compartment NA NA Human Human DTXSID1022687 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022687 TK.Half.Life NA 2.609 hours 1compartment NA NA Human Human -DTXSID1022687 Css NA 0.01355 mg/L 3compartmentss NA 50% Human Human -DTXSID1022687 Css NA 0.1155 mg/L 3compartmentss NA 95% Human Human -DTXSID1022687 Css NA 0.01176 mg/L PBTK NA 50% Human Human -DTXSID1022687 Css NA 0.08441 mg/L PBTK NA 95% Human Human +DTXSID1022687 TK.Half.Life NA 7.199 hours 1compartment NA NA Human Human +DTXSID1022687 Css NA 0.208 mg/L 3compartmentss NA 50% Human Human +DTXSID1022687 Css NA 1.468 mg/L 3compartmentss NA 95% Human Human +DTXSID1022687 Css NA 0.208 mg/L PBTK NA 50% Human Human +DTXSID1022687 Css NA 1.468 mg/L PBTK NA 95% Human Human DTXSID1022687 Clint 37 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID1022687 Fup 0.07 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human -DTXSID1022687 Vd NA 0.9435 L/kg 1compartment NA NA Rat Human +DTXSID1022687 Vd NA 1.762 L/kg 1compartment NA NA Rat Human DTXSID1022687 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022687 TK.Half.Life NA 1.089 hours 1compartment NA NA Rat Human -DTXSID1022687 Css NA 0.1068 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022687 Css NA 0.7097 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022687 Css NA 0.0887 mg/L PBTK NA 50% Rat Human -DTXSID1022687 Css NA 0.5088 mg/L PBTK NA 95% Rat Human -DTXSID1022718 Clint NA 30.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022718 Fup NA 0.9253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022718 Vd NA 3.659 L/kg 1compartment NA NA Human Human +DTXSID1022687 TK.Half.Life NA 2.052 hours 1compartment NA NA Rat Human +DTXSID1022687 Css NA 0.01004 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022687 Css NA 0.07026 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022687 Css NA 0.01018 mg/L PBTK NA 50% Rat Human +DTXSID1022687 Css NA 0.07191 mg/L PBTK NA 95% Rat Human +DTXSID1022714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022714 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1022714 Vd NA 3.367 L/kg 1compartment NA NA Human Human +DTXSID1022714 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1022714 TK.Half.Life NA 13.74 hours 1compartment NA NA Human Human +DTXSID1022714 Css NA 0.3702 mg/L 3compartmentss NA 50% Human Human +DTXSID1022714 Css NA 2.406 mg/L 3compartmentss NA 95% Human Human +DTXSID1022714 Css NA 0.2826 mg/L PBTK NA 50% Human Human +DTXSID1022714 Css NA 1.741 mg/L PBTK NA 95% Human Human +DTXSID1022714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022714 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1022714 Vd NA 2.668 L/kg 1compartment NA NA Rat Human +DTXSID1022714 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1022714 TK.Half.Life NA 2.747 hours 1compartment NA NA Rat Human +DTXSID1022714 Css NA 0.04734 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022714 Css NA 0.2516 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022714 Css NA 0.03626 mg/L PBTK NA 50% Rat Human +DTXSID1022714 Css NA 0.1855 mg/L PBTK NA 95% Rat Human +DTXSID1022718 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022718 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022718 Vd NA 3.173 L/kg 1compartment NA NA Human Human DTXSID1022718 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022718 TK.Half.Life NA 4.606 hours 1compartment NA NA Human Human -DTXSID1022718 Css NA 0.06537 mg/L 3compartmentss NA 50% Human Human -DTXSID1022718 Css NA 0.4406 mg/L 3compartmentss NA 95% Human Human -DTXSID1022718 Css NA 0.05954 mg/L PBTK NA 50% Human Human -DTXSID1022718 Css NA 0.3608 mg/L PBTK NA 95% Human Human -DTXSID1022718 Clint NA 30.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022718 Fup NA 0.9253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022718 Vd NA 3.045 L/kg 1compartment NA NA Rat Human +DTXSID1022718 TK.Half.Life NA 5.728 hours 1compartment NA NA Human Human +DTXSID1022718 Css NA 0.12 mg/L 3compartmentss NA 50% Human Human +DTXSID1022718 Css NA 0.8045 mg/L 3compartmentss NA 95% Human Human +DTXSID1022718 Css NA 0.1009 mg/L PBTK NA 50% Human Human +DTXSID1022718 Css NA 0.6152 mg/L PBTK NA 95% Human Human +DTXSID1022718 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022718 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022718 Vd NA 2.623 L/kg 1compartment NA NA Rat Human DTXSID1022718 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022718 TK.Half.Life NA 1.242 hours 1compartment NA NA Rat Human -DTXSID1022718 Css NA 0.03516 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022718 Css NA 0.1893 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022718 Css NA 0.03152 mg/L PBTK NA 50% Rat Human -DTXSID1022718 Css NA 0.1552 mg/L PBTK NA 95% Rat Human -DTXSID1022760 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1022718 TK.Half.Life NA 1.693 hours 1compartment NA NA Rat Human +DTXSID1022718 Css NA 0.01472 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022718 Css NA 0.0759 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022718 Css NA 0.01264 mg/L PBTK NA 50% Rat Human +DTXSID1022718 Css NA 0.06138 mg/L PBTK NA 95% Rat Human +DTXSID1022760 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1022760 Fup 0.19 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1022760 Vd NA 0.4018 L/kg 1compartment NA NA Human Human +DTXSID1022760 Vd NA 0.3104 L/kg 1compartment NA NA Human Human DTXSID1022760 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1022760 TK.Half.Life NA 13.69 hours 1compartment NA NA Human Human -DTXSID1022760 Css NA 4.236 mg/L 3compartmentss NA 50% Human Human -DTXSID1022760 Css NA 14.93 mg/L 3compartmentss NA 95% Human Human -DTXSID1022760 Css NA 2.772 mg/L PBTK NA 50% Human Human -DTXSID1022760 Css NA 9.137 mg/L PBTK NA 95% Human Human -DTXSID1022760 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1022760 TK.Half.Life NA 10.57 hours 1compartment NA NA Human Human +DTXSID1022760 Css NA 2.323 mg/L 3compartmentss NA 50% Human Human +DTXSID1022760 Css NA 8.844 mg/L 3compartmentss NA 95% Human Human +DTXSID1022760 Css NA 1.499 mg/L PBTK NA 50% Human Human +DTXSID1022760 Css NA 5.305 mg/L PBTK NA 95% Human Human +DTXSID1022760 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1022760 Fup 0.19 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1022760 Vd NA 0.4053 L/kg 1compartment NA NA Rat Human +DTXSID1022760 Vd NA 0.3278 L/kg 1compartment NA NA Rat Human DTXSID1022760 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022760 TK.Half.Life NA 4.702 hours 1compartment NA NA Rat Human -DTXSID1022760 Css NA 1.178 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022760 Css NA 3.465 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022760 Css NA 0.7282 mg/L PBTK NA 50% Rat Human -DTXSID1022760 Css NA 1.971 mg/L PBTK NA 95% Rat Human -DTXSID1022762 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1022760 TK.Half.Life NA 3.804 hours 1compartment NA NA Rat Human +DTXSID1022760 Css NA 0.0124 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022760 Css NA 0.04999 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022760 Css NA 0.007536 mg/L PBTK NA 50% Rat Human +DTXSID1022760 Css NA 0.02876 mg/L PBTK NA 95% Rat Human +DTXSID1022762 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1022762 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1022762 Vd NA 0.265 L/kg 1compartment NA NA Human Human +DTXSID1022762 Vd NA 0.248 L/kg 1compartment NA NA Human Human DTXSID1022762 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1022762 TK.Half.Life NA 11.43 hours 1compartment NA NA Human Human -DTXSID1022762 Css NA 6.3 mg/L 3compartmentss NA 50% Human Human -DTXSID1022762 Css NA 27.21 mg/L 3compartmentss NA 95% Human Human -DTXSID1022762 Css NA 3.932 mg/L PBTK NA 50% Human Human -DTXSID1022762 Css NA 16.15 mg/L PBTK NA 95% Human Human -DTXSID1022762 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1022762 TK.Half.Life NA 10.7 hours 1compartment NA NA Human Human +DTXSID1022762 Css NA 3.338 mg/L 3compartmentss NA 50% Human Human +DTXSID1022762 Css NA 16.01 mg/L 3compartmentss NA 95% Human Human +DTXSID1022762 Css NA 2.08 mg/L PBTK NA 50% Human Human +DTXSID1022762 Css NA 9.491 mg/L PBTK NA 95% Human Human +DTXSID1022762 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1022762 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1022762 Vd NA 0.2701 L/kg 1compartment NA NA Rat Human +DTXSID1022762 Vd NA 0.2556 L/kg 1compartment NA NA Rat Human DTXSID1022762 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022762 TK.Half.Life NA 3.97 hours 1compartment NA NA Rat Human -DTXSID1022762 Css NA 1.779 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022762 Css NA 6.578 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022762 Css NA 1.038 mg/L PBTK NA 50% Rat Human -DTXSID1022762 Css NA 3.634 mg/L PBTK NA 95% Rat Human -DTXSID1022764 Clint NA 0.8889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1022762 TK.Half.Life NA 3.757 hours 1compartment NA NA Rat Human +DTXSID1022762 Css NA 0.01874 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022762 Css NA 0.0847 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022762 Css NA 0.01091 mg/L PBTK NA 50% Rat Human +DTXSID1022762 Css NA 0.04742 mg/L PBTK NA 95% Rat Human +DTXSID1022764 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1022764 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1022764 Vd NA 0.4716 L/kg 1compartment NA NA Human Human DTXSID1022764 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022764 TK.Half.Life NA 1.784 hours 1compartment NA NA Human Human -DTXSID1022764 Css NA 0.4652 mg/L 3compartmentss NA 50% Human Human -DTXSID1022764 Css NA 3.007 mg/L 3compartmentss NA 95% Human Human -DTXSID1022764 Css NA 0.344 mg/L PBTK NA 50% Human Human -DTXSID1022764 Css NA 1.9 mg/L PBTK NA 95% Human Human -DTXSID1022764 Clint NA 0.8889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1022764 TK.Half.Life NA 4.181 hours 1compartment NA NA Human Human +DTXSID1022764 Css NA 0.6265 mg/L 3compartmentss NA 50% Human Human +DTXSID1022764 Css NA 3.777 mg/L 3compartmentss NA 95% Human Human +DTXSID1022764 Css NA 0.4673 mg/L PBTK NA 50% Human Human +DTXSID1022764 Css NA 2.399 mg/L PBTK NA 95% Human Human +DTXSID1022764 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1022764 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1022764 Vd NA 0.487 L/kg 1compartment NA NA Rat Human DTXSID1022764 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022764 TK.Half.Life NA 0.8754 hours 1compartment NA NA Rat Human -DTXSID1022764 Css NA 0.1754 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022764 Css NA 1.049 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022764 Css NA 0.1256 mg/L PBTK NA 50% Rat Human -DTXSID1022764 Css NA 0.6045 mg/L PBTK NA 95% Rat Human -DTXSID1022766 Clint NA 214.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022766 Fup NA 0.244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022766 Vd NA 0.3953 L/kg 1compartment NA NA Human Human +DTXSID1022764 TK.Half.Life NA 1.471 hours 1compartment NA NA Rat Human +DTXSID1022764 Css NA 0.003289 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022764 Css NA 0.02058 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022764 Css NA 0.002358 mg/L PBTK NA 50% Rat Human +DTXSID1022764 Css NA 0.01259 mg/L PBTK NA 95% Rat Human +DTXSID1022766 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022766 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022766 Vd NA 0.5562 L/kg 1compartment NA NA Human Human DTXSID1022766 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022766 TK.Half.Life NA 0.358 hours 1compartment NA NA Human Human -DTXSID1022766 Css NA 0.009896 mg/L 3compartmentss NA 50% Human Human -DTXSID1022766 Css NA 0.07466 mg/L 3compartmentss NA 95% Human Human -DTXSID1022766 Css NA 0.006549 mg/L PBTK NA 50% Human Human -DTXSID1022766 Css NA 0.04776 mg/L PBTK NA 95% Human Human -DTXSID1022766 Clint NA 214.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022766 Fup NA 0.244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022766 Vd NA 0.3876 L/kg 1compartment NA NA Rat Human +DTXSID1022766 TK.Half.Life NA 1.322 hours 1compartment NA NA Human Human +DTXSID1022766 Css NA 0.176 mg/L 3compartmentss NA 50% Human Human +DTXSID1022766 Css NA 1.177 mg/L 3compartmentss NA 95% Human Human +DTXSID1022766 Css NA 0.1242 mg/L PBTK NA 50% Human Human +DTXSID1022766 Css NA 0.7671 mg/L PBTK NA 95% Human Human +DTXSID1022766 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022766 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022766 Vd NA 0.5238 L/kg 1compartment NA NA Rat Human DTXSID1022766 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022766 TK.Half.Life NA 0.1593 hours 1compartment NA NA Rat Human -DTXSID1022766 Css NA 0.005515 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022766 Css NA 0.0342 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022766 Css NA 0.003448 mg/L PBTK NA 50% Rat Human -DTXSID1022766 Css NA 0.02017 mg/L PBTK NA 95% Rat Human -DTXSID1022768 Clint NA 0.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1022766 TK.Half.Life NA 0.6998 hours 1compartment NA NA Rat Human +DTXSID1022766 Css NA 0.007911 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022766 Css NA 0.0576 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022766 Css NA 0.005448 mg/L PBTK NA 50% Rat Human +DTXSID1022766 Css NA 0.03668 mg/L PBTK NA 95% Rat Human +DTXSID1022768 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1022768 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1022768 Vd NA 0.303 L/kg 1compartment NA NA Human Human -DTXSID1022768 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1022768 TK.Half.Life NA 10.27 hours 1compartment NA NA Human Human -DTXSID1022768 Css NA 5.322 mg/L 3compartmentss NA 50% Human Human -DTXSID1022768 Css NA 25.32 mg/L 3compartmentss NA 95% Human Human -DTXSID1022768 Css NA 3.256 mg/L PBTK NA 50% Human Human -DTXSID1022768 Css NA 14.78 mg/L PBTK NA 95% Human Human -DTXSID1022768 Clint NA 0.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1022768 Vd NA 0.268 L/kg 1compartment NA NA Human Human +DTXSID1022768 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1022768 TK.Half.Life NA 17.35 hours 1compartment NA NA Human Human +DTXSID1022768 Css NA 5.431 mg/L 3compartmentss NA 50% Human Human +DTXSID1022768 Css NA 26.84 mg/L 3compartmentss NA 95% Human Human +DTXSID1022768 Css NA 3.29 mg/L PBTK NA 50% Human Human +DTXSID1022768 Css NA 15.76 mg/L PBTK NA 95% Human Human +DTXSID1022768 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1022768 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1022768 Vd NA 0.2924 L/kg 1compartment NA NA Rat Human +DTXSID1022768 Vd NA 0.2661 L/kg 1compartment NA NA Rat Human DTXSID1022768 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022768 TK.Half.Life NA 4.46 hours 1compartment NA NA Rat Human -DTXSID1022768 Css NA 2.017 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022768 Css NA 8.157 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022768 Css NA 1.156 mg/L PBTK NA 50% Rat Human -DTXSID1022768 Css NA 4.478 mg/L PBTK NA 95% Rat Human -DTXSID1022843 Clint NA 104.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022843 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022843 Vd NA 2.987 L/kg 1compartment NA NA Human Human -DTXSID1022843 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022843 TK.Half.Life NA 3.588 hours 1compartment NA NA Human Human -DTXSID1022843 Css NA 0.05684 mg/L 3compartmentss NA 50% Human Human -DTXSID1022843 Css NA 0.392 mg/L 3compartmentss NA 95% Human Human -DTXSID1022843 Css NA 0.03988 mg/L PBTK NA 50% Human Human -DTXSID1022843 Css NA 0.2601 mg/L PBTK NA 95% Human Human -DTXSID1022843 Clint NA 104.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022843 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022843 Vd NA 2.312 L/kg 1compartment NA NA Rat Human -DTXSID1022843 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022843 TK.Half.Life NA 1.055 hours 1compartment NA NA Rat Human -DTXSID1022843 Css NA 0.03149 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022843 Css NA 0.1884 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022843 Css NA 0.02123 mg/L PBTK NA 50% Rat Human -DTXSID1022843 Css NA 0.1205 mg/L PBTK NA 95% Rat Human +DTXSID1022768 TK.Half.Life NA 5.869 hours 1compartment NA NA Rat Human +DTXSID1022768 Css NA 0.03034 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022768 Css NA 0.1474 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022768 Css NA 0.01729 mg/L PBTK NA 50% Rat Human +DTXSID1022768 Css NA 0.0817 mg/L PBTK NA 95% Rat Human +DTXSID1022843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022843 Fup 0.00449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022843 Vd NA 16.52 L/kg 1compartment NA NA Human Human +DTXSID1022843 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1022843 TK.Half.Life NA 46.8 hours 1compartment NA NA Human Human +DTXSID1022843 Css NA 0.1529 mg/L 3compartmentss NA 50% Human Human +DTXSID1022843 Css NA 1.575 mg/L 3compartmentss NA 95% Human Human +DTXSID1022843 Css NA 0.251 mg/L PBTK NA 50% Human Human +DTXSID1022843 Css NA 1.884 mg/L PBTK NA 95% Human Human +DTXSID1022843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022843 Fup 0.00449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022843 Vd NA 13.36 L/kg 1compartment NA NA Rat Human +DTXSID1022843 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1022843 TK.Half.Life NA 13.76 hours 1compartment NA NA Rat Human +DTXSID1022843 Css NA 0.01854 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022843 Css NA 0.1689 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022843 Css NA 0.03237 mg/L PBTK NA 50% Rat Human +DTXSID1022843 Css NA 0.2098 mg/L PBTK NA 95% Rat Human DTXSID1022845 Clint 15 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID1022845 Fup 0.21 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID1022845 Vd NA 1.58 L/kg 1compartment NA NA Human Human DTXSID1022845 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1022845 TK.Half.Life NA 3.452 hours 1compartment NA NA Human Human -DTXSID1022845 Css NA 0.1795 mg/L 3compartmentss NA 50% Human Human -DTXSID1022845 Css NA 1.136 mg/L 3compartmentss NA 95% Human Human -DTXSID1022845 Css NA 0.13 mg/L PBTK NA 50% Human Human -DTXSID1022845 Css NA 0.7647 mg/L PBTK NA 95% Human Human +DTXSID1022845 Css NA 0.1712 mg/L 3compartmentss NA 50% Human Human +DTXSID1022845 Css NA 1.147 mg/L 3compartmentss NA 95% Human Human +DTXSID1022845 Css NA 0.1229 mg/L PBTK NA 50% Human Human +DTXSID1022845 Css NA 0.7795 mg/L PBTK NA 95% Human Human DTXSID1022845 Clint 18.54 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID1022845 Fup 0.21 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID1022845 Vd NA 1.243 L/kg 1compartment NA NA Rat Rat DTXSID1022845 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID1022845 TK.Half.Life NA 1.182 hours 1compartment NA NA Rat Rat -DTXSID1022845 Css NA 0.07988 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1022845 Css NA 0.396 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1022845 Css NA 0.05514 mg/L PBTK NA 50% Rat Rat -DTXSID1022845 Css NA 0.2534 mg/L PBTK NA 95% Rat Rat -DTXSID1022847 Clint NA 8.016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022847 Fup NA 0.2222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022847 Vd NA 0.7847 L/kg 1compartment NA NA Human Human +DTXSID1022845 Css NA 0.01758 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1022845 Css NA 0.09093 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1022845 Css NA 0.0126 mg/L PBTK NA 50% Rat Rat +DTXSID1022845 Css NA 0.06108 mg/L PBTK NA 95% Rat Rat +DTXSID1022847 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022847 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022847 Vd NA 0.6547 L/kg 1compartment NA NA Human Human DTXSID1022847 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022847 TK.Half.Life NA 2.132 hours 1compartment NA NA Human Human -DTXSID1022847 Css NA 0.2523 mg/L 3compartmentss NA 50% Human Human -DTXSID1022847 Css NA 1.552 mg/L 3compartmentss NA 95% Human Human -DTXSID1022847 Css NA 0.1779 mg/L PBTK NA 50% Human Human -DTXSID1022847 Css NA 1.024 mg/L PBTK NA 95% Human Human -DTXSID1022847 Clint NA 8.016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022847 Fup NA 0.2222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022847 Vd NA 0.7816 L/kg 1compartment NA NA Rat Human +DTXSID1022847 TK.Half.Life NA 1.239 hours 1compartment NA NA Human Human +DTXSID1022847 Css NA 0.1474 mg/L 3compartmentss NA 50% Human Human +DTXSID1022847 Css NA 1.01 mg/L 3compartmentss NA 95% Human Human +DTXSID1022847 Css NA 0.1105 mg/L PBTK NA 50% Human Human +DTXSID1022847 Css NA 0.6789 mg/L PBTK NA 95% Human Human +DTXSID1022847 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022847 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022847 Vd NA 0.6206 L/kg 1compartment NA NA Rat Human DTXSID1022847 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022847 TK.Half.Life NA 1.242 hours 1compartment NA NA Rat Human -DTXSID1022847 Css NA 0.1314 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022847 Css NA 0.6107 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022847 Css NA 0.08839 mg/L PBTK NA 50% Rat Human -DTXSID1022847 Css NA 0.3697 mg/L PBTK NA 95% Rat Human +DTXSID1022847 TK.Half.Life NA 0.6442 hours 1compartment NA NA Rat Human +DTXSID1022847 Css NA 0.01729 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022847 Css NA 0.09466 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022847 Css NA 0.0128 mg/L PBTK NA 50% Rat Human +DTXSID1022847 Css NA 0.0598 mg/L PBTK NA 95% Rat Human +DTXSID1022893 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022893 Fup 0.59 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1022893 Vd NA 0.5628 L/kg 1compartment NA NA Human Human +DTXSID1022893 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1022893 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human +DTXSID1022893 Css NA 0.7138 mg/L 3compartmentss NA 50% Human Human +DTXSID1022893 Css NA 5.036 mg/L 3compartmentss NA 95% Human Human +DTXSID1022893 Css NA 0.5386 mg/L PBTK NA 50% Human Human +DTXSID1022893 Css NA 3.075 mg/L PBTK NA 95% Human Human +DTXSID1022893 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022893 Fup 0.59 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1022893 Vd NA 0.5783 L/kg 1compartment NA NA Rat Human +DTXSID1022893 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1022893 TK.Half.Life NA 2.161 hours 1compartment NA NA Rat Human +DTXSID1022893 Css NA 0.003825 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022893 Css NA 0.0254 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022893 Css NA 0.002764 mg/L PBTK NA 50% Rat Human +DTXSID1022893 Css NA 0.01522 mg/L PBTK NA 95% Rat Human DTXSID1022897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1022897 Fup NA 0.2452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022897 Vd NA 0.4566 L/kg 1compartment NA NA Human Human +DTXSID1022897 Vd NA 0.4496 L/kg 1compartment NA NA Human Human DTXSID1022897 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1022897 TK.Half.Life NA 12.06 hours 1compartment NA NA Human Human -DTXSID1022897 Css NA 3.179 mg/L 3compartmentss NA 50% Human Human -DTXSID1022897 Css NA 11.63 mg/L 3compartmentss NA 95% Human Human -DTXSID1022897 Css NA 2.15 mg/L PBTK NA 50% Human Human -DTXSID1022897 Css NA 7.258 mg/L PBTK NA 95% Human Human +DTXSID1022897 TK.Half.Life NA 11.87 hours 1compartment NA NA Human Human +DTXSID1022897 Css NA 2.68 mg/L 3compartmentss NA 50% Human Human +DTXSID1022897 Css NA 10.24 mg/L 3compartmentss NA 95% Human Human +DTXSID1022897 Css NA 1.817 mg/L PBTK NA 50% Human Human +DTXSID1022897 Css NA 6.342 mg/L PBTK NA 95% Human Human DTXSID1022897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1022897 Fup NA 0.2452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022897 Vd NA 0.4614 L/kg 1compartment NA NA Rat Human +DTXSID1022897 Vd NA 0.4552 L/kg 1compartment NA NA Rat Human DTXSID1022897 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022897 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human -DTXSID1022897 Css NA 0.8836 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022897 Css NA 2.761 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022897 Css NA 0.5665 mg/L PBTK NA 50% Rat Human -DTXSID1022897 Css NA 1.59 mg/L PBTK NA 95% Rat Human -DTXSID1022922 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022922 Fup NA 0.1602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022922 Vd NA 0.3224 L/kg 1compartment NA NA Human Human -DTXSID1022922 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1022922 TK.Half.Life NA 13.05 hours 1compartment NA NA Human Human -DTXSID1022922 Css NA 5.588 mg/L 3compartmentss NA 50% Human Human -DTXSID1022922 Css NA 22.86 mg/L 3compartmentss NA 95% Human Human -DTXSID1022922 Css NA 3.526 mg/L PBTK NA 50% Human Human -DTXSID1022922 Css NA 13.58 mg/L PBTK NA 95% Human Human -DTXSID1022922 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022922 Fup NA 0.1602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022922 Vd NA 0.3135 L/kg 1compartment NA NA Rat Human +DTXSID1022897 TK.Half.Life NA 4.092 hours 1compartment NA NA Rat Human +DTXSID1022897 Css NA 0.04839 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022897 Css NA 0.2821 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022897 Css NA 0.03144 mg/L PBTK NA 50% Rat Human +DTXSID1022897 Css NA 0.1714 mg/L PBTK NA 95% Rat Human +DTXSID1022922 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022922 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022922 Vd NA 0.3149 L/kg 1compartment NA NA Human Human +DTXSID1022922 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1022922 TK.Half.Life NA 9.396 hours 1compartment NA NA Human Human +DTXSID1022922 Css NA 2.003 mg/L 3compartmentss NA 50% Human Human +DTXSID1022922 Css NA 7.899 mg/L 3compartmentss NA 95% Human Human +DTXSID1022922 Css NA 1.293 mg/L PBTK NA 50% Human Human +DTXSID1022922 Css NA 4.8 mg/L PBTK NA 95% Human Human +DTXSID1022922 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022922 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022922 Vd NA 0.3166 L/kg 1compartment NA NA Rat Human DTXSID1022922 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022922 TK.Half.Life NA 4.319 hours 1compartment NA NA Rat Human -DTXSID1022922 Css NA 1.583 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022922 Css NA 5.471 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022922 Css NA 0.9364 mg/L PBTK NA 50% Rat Human -DTXSID1022922 Css NA 3.041 mg/L PBTK NA 95% Rat Human -DTXSID1022926 Clint NA 31.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022926 Fup NA 0.0776 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022926 Vd NA 3.32 L/kg 1compartment NA NA Human Human -DTXSID1022926 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022926 TK.Half.Life NA 4.268 hours 1compartment NA NA Human Human -DTXSID1022926 Css NA 0.0821 mg/L 3compartmentss NA 50% Human Human -DTXSID1022926 Css NA 0.6999 mg/L 3compartmentss NA 95% Human Human -DTXSID1022926 Css NA 0.07235 mg/L PBTK NA 50% Human Human -DTXSID1022926 Css NA 0.5312 mg/L PBTK NA 95% Human Human -DTXSID1022926 Clint NA 31.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022926 Fup NA 0.0776 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022926 Vd NA 3.042 L/kg 1compartment NA NA Rat Human -DTXSID1022926 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022926 TK.Half.Life NA 1.842 hours 1compartment NA NA Rat Human -DTXSID1022926 Css NA 0.04507 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022926 Css NA 0.3148 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022926 Css NA 0.03877 mg/L PBTK NA 50% Rat Human -DTXSID1022926 Css NA 0.2318 mg/L PBTK NA 95% Rat Human -DTXSID1022974 Clint NA 4.203 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022974 Fup NA 0.0862 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022974 Vd NA 2.631 L/kg 1compartment NA NA Human Human -DTXSID1022974 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID1022974 TK.Half.Life NA 62.11 hours 1compartment NA NA Human Human -DTXSID1022974 Css NA 3.126 mg/L 3compartmentss NA 50% Human Human -DTXSID1022974 Css NA 16.56 mg/L 3compartmentss NA 95% Human Human -DTXSID1022974 Css NA 2.147 mg/L PBTK NA 50% Human Human -DTXSID1022974 Css NA 11.02 mg/L PBTK NA 95% Human Human -DTXSID1022974 Clint NA 4.203 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022974 Fup NA 0.0862 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022974 Vd NA 1.978 L/kg 1compartment NA NA Rat Human -DTXSID1022974 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1022974 TK.Half.Life NA 13.29 hours 1compartment NA NA Rat Human -DTXSID1022974 Css NA 1.633 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022974 Css NA 6.181 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022974 Css NA 1.068 mg/L PBTK NA 50% Rat Human -DTXSID1022974 Css NA 3.83 mg/L PBTK NA 95% Rat Human -DTXSID1022978 Clint NA 0.512 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022978 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1022978 Vd NA 1.954 L/kg 1compartment NA NA Human Human -DTXSID1022978 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1022978 TK.Half.Life NA 9.571 hours 1compartment NA NA Human Human -DTXSID1022978 Css NA 0.4346 mg/L 3compartmentss NA 50% Human Human -DTXSID1022978 Css NA 3.034 mg/L 3compartmentss NA 95% Human Human -DTXSID1022978 Css NA 0.4204 mg/L PBTK NA 50% Human Human -DTXSID1022978 Css NA 2.068 mg/L PBTK NA 95% Human Human -DTXSID1022978 Clint NA 0.512 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022978 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1022978 Vd NA 1.651 L/kg 1compartment NA NA Rat Human +DTXSID1022922 TK.Half.Life NA 3.216 hours 1compartment NA NA Rat Human +DTXSID1022922 Css NA 0.01092 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022922 Css NA 0.04265 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022922 Css NA 0.00667 mg/L PBTK NA 50% Rat Human +DTXSID1022922 Css NA 0.02483 mg/L PBTK NA 95% Rat Human +DTXSID1022924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022924 Fup 0.033 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1022924 Vd NA 0.2327 L/kg 1compartment NA NA Human Human +DTXSID1022924 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1022924 TK.Half.Life NA 1.457 hours 1compartment NA NA Human Human +DTXSID1022924 Css NA 0.9407 mg/L 3compartmentss NA 50% Human Human +DTXSID1022924 Css NA 8.91 mg/L 3compartmentss NA 95% Human Human +DTXSID1022924 Css NA 0.5172 mg/L PBTK NA 50% Human Human +DTXSID1022924 Css NA 4.899 mg/L PBTK NA 95% Human Human +DTXSID1022924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022924 Fup 0.033 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1022924 Vd NA 0.2226 L/kg 1compartment NA NA Rat Human +DTXSID1022924 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1022924 TK.Half.Life NA 0.9748 hours 1compartment NA NA Rat Human +DTXSID1022924 Css NA 0.04866 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022924 Css NA 0.4936 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022924 Css NA 0.02706 mg/L PBTK NA 50% Rat Human +DTXSID1022924 Css NA 0.2771 mg/L PBTK NA 95% Rat Human +DTXSID1022974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022974 Fup 0.0375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022974 Vd NA 1.806 L/kg 1compartment NA NA Human Human +DTXSID1022974 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1022974 TK.Half.Life NA 11.29 hours 1compartment NA NA Human Human +DTXSID1022974 Css NA 0.882 mg/L 3compartmentss NA 50% Human Human +DTXSID1022974 Css NA 7.374 mg/L 3compartmentss NA 95% Human Human +DTXSID1022974 Css NA 0.5653 mg/L PBTK NA 50% Human Human +DTXSID1022974 Css NA 4.475 mg/L PBTK NA 95% Human Human +DTXSID1022974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022974 Fup 0.0375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022974 Vd NA 1.349 L/kg 1compartment NA NA Rat Human +DTXSID1022974 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1022974 TK.Half.Life NA 3.943 hours 1compartment NA NA Rat Human +DTXSID1022974 Css NA 0.1151 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022974 Css NA 0.7411 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022974 Css NA 0.07215 mg/L PBTK NA 50% Rat Human +DTXSID1022974 Css NA 0.449 mg/L PBTK NA 95% Rat Human +DTXSID1022978 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022978 Fup 0.518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1022978 Vd NA 1.152 L/kg 1compartment NA NA Human Human +DTXSID1022978 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1022978 TK.Half.Life NA 15.98 hours 1compartment NA NA Human Human +DTXSID1022978 Css NA 1.428 mg/L 3compartmentss NA 50% Human Human +DTXSID1022978 Css NA 7.714 mg/L 3compartmentss NA 95% Human Human +DTXSID1022978 Css NA 1.158 mg/L PBTK NA 50% Human Human +DTXSID1022978 Css NA 4.976 mg/L PBTK NA 95% Human Human +DTXSID1022978 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022978 Fup 0.518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1022978 Vd NA 0.9987 L/kg 1compartment NA NA Rat Human DTXSID1022978 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1022978 TK.Half.Life NA 2.817 hours 1compartment NA NA Rat Human -DTXSID1022978 Css NA 0.1456 mg/L 3compartmentss NA 50% Rat Human -DTXSID1022978 Css NA 0.9263 mg/L 3compartmentss NA 95% Rat Human -DTXSID1022978 Css NA 0.1406 mg/L PBTK NA 50% Rat Human -DTXSID1022978 Css NA 0.5915 mg/L PBTK NA 95% Rat Human -DTXSID1023021 Clint NA 2.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023021 Fup NA 0.1322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023021 Vd NA 0.8672 L/kg 1compartment NA NA Human Human +DTXSID1022978 TK.Half.Life NA 4.362 hours 1compartment NA NA Rat Human +DTXSID1022978 Css NA 0.08934 mg/L 3compartmentss NA 50% Rat Human +DTXSID1022978 Css NA 0.4304 mg/L 3compartmentss NA 95% Rat Human +DTXSID1022978 Css NA 0.07214 mg/L PBTK NA 50% Rat Human +DTXSID1022978 Css NA 0.2696 mg/L PBTK NA 95% Rat Human +DTXSID1023021 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023021 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023021 Vd NA 0.9694 L/kg 1compartment NA NA Human Human DTXSID1023021 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023021 TK.Half.Life NA 8.827 hours 1compartment NA NA Human Human -DTXSID1023021 Css NA 1.433 mg/L 3compartmentss NA 50% Human Human -DTXSID1023021 Css NA 8.47 mg/L 3compartmentss NA 95% Human Human -DTXSID1023021 Css NA 0.9398 mg/L PBTK NA 50% Human Human -DTXSID1023021 Css NA 5.152 mg/L PBTK NA 95% Human Human -DTXSID1023021 Clint NA 2.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023021 Fup NA 0.1322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023021 Vd NA 0.7049 L/kg 1compartment NA NA Rat Human +DTXSID1023021 TK.Half.Life NA 4.211 hours 1compartment NA NA Human Human +DTXSID1023021 Css NA 0.4837 mg/L 3compartmentss NA 50% Human Human +DTXSID1023021 Css NA 2.975 mg/L 3compartmentss NA 95% Human Human +DTXSID1023021 Css NA 0.3264 mg/L PBTK NA 50% Human Human +DTXSID1023021 Css NA 1.908 mg/L PBTK NA 95% Human Human +DTXSID1023021 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023021 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023021 Vd NA 0.7892 L/kg 1compartment NA NA Rat Human DTXSID1023021 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023021 TK.Half.Life NA 3.859 hours 1compartment NA NA Rat Human -DTXSID1023021 Css NA 0.6984 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023021 Css NA 3.091 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023021 Css NA 0.4348 mg/L PBTK NA 50% Rat Human -DTXSID1023021 Css NA 1.75 mg/L PBTK NA 95% Rat Human -DTXSID1023027 Clint NA 48.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1023021 TK.Half.Life NA 1.917 hours 1compartment NA NA Rat Human +DTXSID1023021 Css NA 0.05876 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023021 Css NA 0.2638 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023021 Css NA 0.03922 mg/L PBTK NA 50% Rat Human +DTXSID1023021 Css NA 0.1638 mg/L PBTK NA 95% Rat Human +DTXSID1023027 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1023027 Fup 0.06 NA NA https://doi.org/10.1002/bdd.711 NA Human Human DTXSID1023027 Vd NA 2.486 L/kg 1compartment NA NA Human Human -DTXSID1023027 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023027 TK.Half.Life NA 8.304 hours 1compartment NA NA Human Human -DTXSID1023027 Css NA 0.405 mg/L 3compartmentss NA 50% Human Human -DTXSID1023027 Css NA 2.695 mg/L 3compartmentss NA 95% Human Human -DTXSID1023027 Css NA 0.2399 mg/L PBTK NA 50% Human Human -DTXSID1023027 Css NA 1.553 mg/L PBTK NA 95% Human Human -DTXSID1023027 Clint NA 48.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1023027 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1023027 TK.Half.Life NA 15.66 hours 1compartment NA NA Human Human +DTXSID1023027 Css NA 0.8651 mg/L 3compartmentss NA 50% Human Human +DTXSID1023027 Css NA 5.517 mg/L 3compartmentss NA 95% Human Human +DTXSID1023027 Css NA 0.5189 mg/L PBTK NA 50% Human Human +DTXSID1023027 Css NA 3.308 mg/L PBTK NA 95% Human Human +DTXSID1023027 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1023027 Fup 0.06 NA NA https://doi.org/10.1002/bdd.711 NA Rat Human DTXSID1023027 Vd NA 1.865 L/kg 1compartment NA NA Rat Human DTXSID1023027 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023027 TK.Half.Life NA 2.254 hours 1compartment NA NA Rat Human -DTXSID1023027 Css NA 0.2317 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023027 Css NA 1.268 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023027 Css NA 0.1279 mg/L PBTK NA 50% Rat Human -DTXSID1023027 Css NA 0.6967 mg/L PBTK NA 95% Rat Human -DTXSID1023071 Clint NA 12.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023071 Fup NA 0.1076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023071 Vd NA 2.515 L/kg 1compartment NA NA Human Human -DTXSID1023071 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1023071 TK.Half.Life NA 16.52 hours 1compartment NA NA Human Human -DTXSID1023071 Css NA 0.7989 mg/L 3compartmentss NA 50% Human Human -DTXSID1023071 Css NA 5.103 mg/L 3compartmentss NA 95% Human Human -DTXSID1023071 Css NA 0.553 mg/L PBTK NA 50% Human Human -DTXSID1023071 Css NA 3.371 mg/L PBTK NA 95% Human Human -DTXSID1023071 Clint NA 12.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023071 Fup NA 0.1076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023071 Vd NA 1.897 L/kg 1compartment NA NA Rat Human +DTXSID1023027 TK.Half.Life NA 4.063 hours 1compartment NA NA Rat Human +DTXSID1023027 Css NA 0.105 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023027 Css NA 0.5642 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023027 Css NA 0.06526 mg/L PBTK NA 50% Rat Human +DTXSID1023027 Css NA 0.3505 mg/L PBTK NA 95% Rat Human +DTXSID1023029 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023029 Fup 0.77 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1023029 Vd NA 7.618 L/kg 1compartment NA NA Human Human +DTXSID1023029 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID1023029 TK.Half.Life NA 88.82 hours 1compartment NA NA Human Human +DTXSID1023029 Css NA 0.5059 mg/L 3compartmentss NA 50% Human Human +DTXSID1023029 Css NA 4.462 mg/L 3compartmentss NA 95% Human Human +DTXSID1023029 Css NA 1.014 mg/L PBTK NA 50% Human Human +DTXSID1023029 Css NA 4.462 mg/L PBTK NA 95% Human Human +DTXSID1023029 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023029 Fup 0.77 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1023029 Vd NA 7.742 L/kg 1compartment NA NA Rat Human +DTXSID1023029 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID1023029 TK.Half.Life NA 24.22 hours 1compartment NA NA Rat Human +DTXSID1023029 Css NA 0.02846 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023029 Css NA 0.2569 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023029 Css NA 0.06166 mg/L PBTK NA 50% Rat Human +DTXSID1023029 Css NA 0.2466 mg/L PBTK NA 95% Rat Human +DTXSID1023071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023071 Fup 0.0883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023071 Vd NA 2.503 L/kg 1compartment NA NA Human Human +DTXSID1023071 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1023071 TK.Half.Life NA 11.78 hours 1compartment NA NA Human Human +DTXSID1023071 Css NA 0.5367 mg/L 3compartmentss NA 50% Human Human +DTXSID1023071 Css NA 3.556 mg/L 3compartmentss NA 95% Human Human +DTXSID1023071 Css NA 0.3667 mg/L PBTK NA 50% Human Human +DTXSID1023071 Css NA 2.369 mg/L PBTK NA 95% Human Human +DTXSID1023071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023071 Fup 0.0883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023071 Vd NA 1.896 L/kg 1compartment NA NA Rat Human DTXSID1023071 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023071 TK.Half.Life NA 4.181 hours 1compartment NA NA Rat Human -DTXSID1023071 Css NA 0.4404 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023071 Css NA 2.044 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023071 Css NA 0.2895 mg/L PBTK NA 50% Rat Human -DTXSID1023071 Css NA 1.289 mg/L PBTK NA 95% Rat Human -DTXSID1023102 Clint NA 1.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023102 Fup NA 0.3048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023102 Vd NA 1.053 L/kg 1compartment NA NA Human Human +DTXSID1023071 TK.Half.Life NA 3.144 hours 1compartment NA NA Rat Human +DTXSID1023071 Css NA 0.06796 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023071 Css NA 0.367 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023071 Css NA 0.04625 mg/L PBTK NA 50% Rat Human +DTXSID1023071 Css NA 0.2402 mg/L PBTK NA 95% Rat Human +DTXSID1023077 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023077 Fup 0.346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023077 Vd NA 1.45 L/kg 1compartment NA NA Human Human +DTXSID1023077 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1023077 TK.Half.Life NA 3.156 hours 1compartment NA NA Human Human +DTXSID1023077 Css NA 0.1426 mg/L 3compartmentss NA 50% Human Human +DTXSID1023077 Css NA 0.9851 mg/L 3compartmentss NA 95% Human Human +DTXSID1023077 Css NA 0.1204 mg/L PBTK NA 50% Human Human +DTXSID1023077 Css NA 0.723 mg/L PBTK NA 95% Human Human +DTXSID1023077 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023077 Fup 0.346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023077 Vd NA 1.458 L/kg 1compartment NA NA Rat Human +DTXSID1023077 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1023077 TK.Half.Life NA 1.822 hours 1compartment NA NA Rat Human +DTXSID1023077 Css NA 0.005571 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023077 Css NA 0.04431 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023077 Css NA 0.004749 mg/L PBTK NA 50% Rat Human +DTXSID1023077 Css NA 0.03151 mg/L PBTK NA 95% Rat Human +DTXSID1023102 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023102 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023102 Vd NA 0.9555 L/kg 1compartment NA NA Human Human DTXSID1023102 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023102 TK.Half.Life NA 6.107 hours 1compartment NA NA Human Human -DTXSID1023102 Css NA 0.6195 mg/L 3compartmentss NA 50% Human Human -DTXSID1023102 Css NA 2.949 mg/L 3compartmentss NA 95% Human Human -DTXSID1023102 Css NA 0.4578 mg/L PBTK NA 50% Human Human -DTXSID1023102 Css NA 1.903 mg/L PBTK NA 95% Human Human -DTXSID1023102 Clint NA 1.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023102 Fup NA 0.3048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023102 Vd NA 0.8824 L/kg 1compartment NA NA Rat Human +DTXSID1023102 TK.Half.Life NA 1.386 hours 1compartment NA NA Human Human +DTXSID1023102 Css NA 0.08438 mg/L 3compartmentss NA 50% Human Human +DTXSID1023102 Css NA 0.6046 mg/L 3compartmentss NA 95% Human Human +DTXSID1023102 Css NA 0.06014 mg/L PBTK NA 50% Human Human +DTXSID1023102 Css NA 0.4024 mg/L PBTK NA 95% Human Human +DTXSID1023102 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023102 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023102 Vd NA 0.7998 L/kg 1compartment NA NA Rat Human DTXSID1023102 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023102 TK.Half.Life NA 2.577 hours 1compartment NA NA Rat Human -DTXSID1023102 Css NA 0.2798 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023102 Css NA 1.063 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023102 Css NA 0.1972 mg/L PBTK NA 50% Rat Human -DTXSID1023102 Css NA 0.6456 mg/L PBTK NA 95% Rat Human +DTXSID1023102 TK.Half.Life NA 0.6075 hours 1compartment NA NA Rat Human +DTXSID1023102 Css NA 0.01059 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023102 Css NA 0.05739 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023102 Css NA 0.007477 mg/L PBTK NA 50% Rat Human +DTXSID1023102 Css NA 0.0379 mg/L PBTK NA 95% Rat Human DTXSID1023150 Clint NA 9.532 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1023150 Fup NA 0.103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023150 Vd NA 0.2438 L/kg 1compartment NA NA Human Human +DTXSID1023150 Vd NA 0.2792 L/kg 1compartment NA NA Human Human DTXSID1023150 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023150 TK.Half.Life NA 1.11 hours 1compartment NA NA Human Human -DTXSID1023150 Css NA 0.645 mg/L 3compartmentss NA 50% Human Human -DTXSID1023150 Css NA 4.692 mg/L 3compartmentss NA 95% Human Human -DTXSID1023150 Css NA 0.3929 mg/L PBTK NA 50% Human Human -DTXSID1023150 Css NA 2.785 mg/L PBTK NA 95% Human Human +DTXSID1023150 TK.Half.Life NA 1.27 hours 1compartment NA NA Human Human +DTXSID1023150 Css NA 0.3292 mg/L 3compartmentss NA 50% Human Human +DTXSID1023150 Css NA 2.614 mg/L 3compartmentss NA 95% Human Human +DTXSID1023150 Css NA 0.2046 mg/L PBTK NA 50% Human Human +DTXSID1023150 Css NA 1.554 mg/L PBTK NA 95% Human Human DTXSID1023150 Clint NA 9.532 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1023150 Fup NA 0.103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023150 Vd NA 0.243 L/kg 1compartment NA NA Rat Human +DTXSID1023150 Vd NA 0.2746 L/kg 1compartment NA NA Rat Human DTXSID1023150 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023150 TK.Half.Life NA 0.6762 hours 1compartment NA NA Rat Human -DTXSID1023150 Css NA 0.3552 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023150 Css NA 1.915 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023150 Css NA 0.2028 mg/L PBTK NA 50% Rat Human -DTXSID1023150 Css NA 1.056 mg/L PBTK NA 95% Rat Human +DTXSID1023150 TK.Half.Life NA 0.7641 hours 1compartment NA NA Rat Human +DTXSID1023150 Css NA 0.003448 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023150 Css NA 0.02317 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023150 Css NA 0.002011 mg/L PBTK NA 50% Rat Human +DTXSID1023150 Css NA 0.01301 mg/L PBTK NA 95% Rat Human DTXSID1023158 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1023158 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1023158 Vd NA 0.5418 L/kg 1compartment NA NA Human Human DTXSID1023158 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1023158 TK.Half.Life NA 3.506 hours 1compartment NA NA Human Human -DTXSID1023158 Css NA 0.9112 mg/L 3compartmentss NA 50% Human Human -DTXSID1023158 Css NA 5.669 mg/L 3compartmentss NA 95% Human Human -DTXSID1023158 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID1023158 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID1023158 Css NA 0.4982 mg/L 3compartmentss NA 50% Human Human +DTXSID1023158 Css NA 3.117 mg/L 3compartmentss NA 95% Human Human +DTXSID1023158 Css NA 0.3817 mg/L PBTK NA 50% Human Human +DTXSID1023158 Css NA 1.998 mg/L PBTK NA 95% Human Human DTXSID1023158 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1023158 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1023158 Vd NA 0.5802 L/kg 1compartment NA NA Rat Human DTXSID1023158 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1023158 TK.Half.Life NA 1.279 hours 1compartment NA NA Rat Human -DTXSID1023158 Css NA 0.2311 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023158 Css NA 1.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023158 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID1023158 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID1023231 Clint NA 8.142 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023231 Fup NA 0.079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023231 Vd NA 1.665 L/kg 1compartment NA NA Human Human -DTXSID1023231 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1023231 TK.Half.Life NA 12.73 hours 1compartment NA NA Human Human -DTXSID1023231 Css NA 1.086 mg/L 3compartmentss NA 50% Human Human -DTXSID1023231 Css NA 7.219 mg/L 3compartmentss NA 95% Human Human -DTXSID1023231 Css NA 0.7119 mg/L PBTK NA 50% Human Human -DTXSID1023231 Css NA 4.494 mg/L PBTK NA 95% Human Human -DTXSID1023231 Clint NA 8.142 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023231 Fup NA 0.079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023231 Vd NA 1.266 L/kg 1compartment NA NA Rat Human +DTXSID1023158 Css NA 0.002513 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023158 Css NA 0.01771 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023158 Css NA 0.001866 mg/L PBTK NA 50% Rat Human +DTXSID1023158 Css NA 0.01062 mg/L PBTK NA 95% Rat Human +DTXSID1023231 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023231 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023231 Vd NA 2.18 L/kg 1compartment NA NA Human Human +DTXSID1023231 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1023231 TK.Half.Life NA 5.462 hours 1compartment NA NA Human Human +DTXSID1023231 Css NA 0.2187 mg/L 3compartmentss NA 50% Human Human +DTXSID1023231 Css NA 1.509 mg/L 3compartmentss NA 95% Human Human +DTXSID1023231 Css NA 0.1558 mg/L PBTK NA 50% Human Human +DTXSID1023231 Css NA 1.017 mg/L PBTK NA 95% Human Human +DTXSID1023231 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023231 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023231 Vd NA 1.672 L/kg 1compartment NA NA Rat Human DTXSID1023231 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023231 TK.Half.Life NA 4.677 hours 1compartment NA NA Rat Human -DTXSID1023231 Css NA 0.5802 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023231 Css NA 2.799 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023231 Css NA 0.3614 mg/L PBTK NA 50% Rat Human -DTXSID1023231 Css NA 1.657 mg/L PBTK NA 95% Rat Human +DTXSID1023231 TK.Half.Life NA 1.751 hours 1compartment NA NA Rat Human +DTXSID1023231 Css NA 0.02787 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023231 Css NA 0.1449 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023231 Css NA 0.01962 mg/L PBTK NA 50% Rat Human +DTXSID1023231 Css NA 0.0966 mg/L PBTK NA 95% Rat Human DTXSID1023235 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1023235 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1023235 Vd NA 0.6753 L/kg 1compartment NA NA Human Human DTXSID1023235 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1023235 TK.Half.Life NA 4.37 hours 1compartment NA NA Human Human -DTXSID1023235 Css NA 0.8569 mg/L 3compartmentss NA 50% Human Human -DTXSID1023235 Css NA 5.588 mg/L 3compartmentss NA 95% Human Human -DTXSID1023235 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID1023235 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID1023235 Css NA 0.6493 mg/L 3compartmentss NA 50% Human Human +DTXSID1023235 Css NA 4.21 mg/L 3compartmentss NA 95% Human Human +DTXSID1023235 Css NA 0.5293 mg/L PBTK NA 50% Human Human +DTXSID1023235 Css NA 2.739 mg/L PBTK NA 95% Human Human DTXSID1023235 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1023235 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1023235 Vd NA 0.7232 L/kg 1compartment NA NA Rat Human DTXSID1023235 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1023235 TK.Half.Life NA 1.595 hours 1compartment NA NA Rat Human -DTXSID1023235 Css NA 0.2156 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023235 Css NA 1.344 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023235 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID1023235 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID1023239 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023239 Fup NA 0.4948 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023239 Vd NA 1.228 L/kg 1compartment NA NA Human Human +DTXSID1023235 Css NA 0.006273 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023235 Css NA 0.06044 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023235 Css NA 0.004896 mg/L PBTK NA 50% Rat Human +DTXSID1023235 Css NA 0.04228 mg/L PBTK NA 95% Rat Human +DTXSID1023239 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023239 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023239 Vd NA 1.236 L/kg 1compartment NA NA Human Human DTXSID1023239 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1023239 TK.Half.Life NA 17.79 hours 1compartment NA NA Human Human -DTXSID1023239 Css NA 1.483 mg/L 3compartmentss NA 50% Human Human -DTXSID1023239 Css NA 7.61 mg/L 3compartmentss NA 95% Human Human -DTXSID1023239 Css NA 1.232 mg/L PBTK NA 50% Human Human -DTXSID1023239 Css NA 5.015 mg/L PBTK NA 95% Human Human -DTXSID1023239 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023239 Fup NA 0.4948 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023239 Vd NA 1.082 L/kg 1compartment NA NA Rat Human +DTXSID1023239 TK.Half.Life NA 17.74 hours 1compartment NA NA Human Human +DTXSID1023239 Css NA 1.412 mg/L 3compartmentss NA 50% Human Human +DTXSID1023239 Css NA 7.341 mg/L 3compartmentss NA 95% Human Human +DTXSID1023239 Css NA 1.178 mg/L PBTK NA 50% Human Human +DTXSID1023239 Css NA 4.815 mg/L PBTK NA 95% Human Human +DTXSID1023239 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023239 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023239 Vd NA 1.088 L/kg 1compartment NA NA Rat Human DTXSID1023239 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023239 TK.Half.Life NA 4.944 hours 1compartment NA NA Rat Human -DTXSID1023239 Css NA 0.3975 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023239 Css NA 1.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023239 Css NA 0.3184 mg/L PBTK NA 50% Rat Human -DTXSID1023239 Css NA 1.107 mg/L PBTK NA 95% Rat Human -DTXSID1023281 Clint NA 0.7143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023281 Fup NA 0.3565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023281 Vd NA 0.352 L/kg 1compartment NA NA Human Human +DTXSID1023239 TK.Half.Life NA 4.923 hours 1compartment NA NA Rat Human +DTXSID1023239 Css NA 0.08822 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023239 Css NA 0.4144 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023239 Css NA 0.07346 mg/L PBTK NA 50% Rat Human +DTXSID1023239 Css NA 0.2636 mg/L PBTK NA 95% Rat Human +DTXSID1023281 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023281 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023281 Vd NA 0.4168 L/kg 1compartment NA NA Human Human DTXSID1023281 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023281 TK.Half.Life NA 3.012 hours 1compartment NA NA Human Human -DTXSID1023281 Css NA 1.019 mg/L 3compartmentss NA 50% Human Human -DTXSID1023281 Css NA 4.467 mg/L 3compartmentss NA 95% Human Human -DTXSID1023281 Css NA 0.6902 mg/L PBTK NA 50% Human Human -DTXSID1023281 Css NA 2.754 mg/L PBTK NA 95% Human Human -DTXSID1023281 Clint NA 0.7143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023281 Fup NA 0.3565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023281 Vd NA 0.3586 L/kg 1compartment NA NA Rat Human +DTXSID1023281 TK.Half.Life NA 5.311 hours 1compartment NA NA Human Human +DTXSID1023281 Css NA 1.5 mg/L 3compartmentss NA 50% Human Human +DTXSID1023281 Css NA 7.655 mg/L 3compartmentss NA 95% Human Human +DTXSID1023281 Css NA 1.068 mg/L PBTK NA 50% Human Human +DTXSID1023281 Css NA 4.693 mg/L PBTK NA 95% Human Human +DTXSID1023281 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023281 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023281 Vd NA 0.426 L/kg 1compartment NA NA Rat Human DTXSID1023281 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023281 TK.Half.Life NA 1.426 hours 1compartment NA NA Rat Human -DTXSID1023281 Css NA 0.3883 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023281 Css NA 1.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023281 Css NA 0.2481 mg/L PBTK NA 50% Rat Human -DTXSID1023281 Css NA 0.8248 mg/L PBTK NA 95% Rat Human +DTXSID1023281 TK.Half.Life NA 1.849 hours 1compartment NA NA Rat Human +DTXSID1023281 Css NA 0.09468 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023281 Css NA 0.4393 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023281 Css NA 0.0661 mg/L PBTK NA 50% Rat Human +DTXSID1023281 Css NA 0.2613 mg/L PBTK NA 95% Rat Human DTXSID1023287 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1023287 Fup 0.27 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID1023287 Vd NA 1.538 L/kg 1compartment NA NA Human Human -DTXSID1023287 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID1023287 TK.Half.Life NA 48.71 hours 1compartment NA NA Human Human -DTXSID1023287 Css NA 3.868 mg/L 3compartmentss NA 50% Human Human -DTXSID1023287 Css NA 13.25 mg/L 3compartmentss NA 95% Human Human -DTXSID1023287 Css NA 2.621 mg/L PBTK NA 50% Human Human -DTXSID1023287 Css NA 8.226 mg/L PBTK NA 95% Human Human +DTXSID1023287 Vd NA 1.08 L/kg 1compartment NA NA Human Human +DTXSID1023287 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1023287 TK.Half.Life NA 28.98 hours 1compartment NA NA Human Human +DTXSID1023287 Css NA 3.02 mg/L 3compartmentss NA 50% Human Human +DTXSID1023287 Css NA 10.35 mg/L 3compartmentss NA 95% Human Human +DTXSID1023287 Css NA 2.114 mg/L PBTK NA 50% Human Human +DTXSID1023287 Css NA 7.242 mg/L PBTK NA 95% Human Human DTXSID1023287 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID1023287 Fup 0.27 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human -DTXSID1023287 Vd NA 1.23 L/kg 1compartment NA NA Rat Human -DTXSID1023287 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1023287 TK.Half.Life NA 10.82 hours 1compartment NA NA Rat Human -DTXSID1023287 Css NA 1.062 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023287 Css NA 2.944 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023287 Css NA 0.6846 mg/L PBTK NA 50% Rat Human -DTXSID1023287 Css NA 1.713 mg/L PBTK NA 95% Rat Human -DTXSID1023310 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023310 Fup NA 0.6496 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023310 Vd NA 0.3748 L/kg 1compartment NA NA Human Human +DTXSID1023287 Vd NA 0.9045 L/kg 1compartment NA NA Rat Human +DTXSID1023287 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1023287 TK.Half.Life NA 7.598 hours 1compartment NA NA Rat Human +DTXSID1023287 Css NA 0.1871 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023287 Css NA 0.5068 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023287 Css NA 0.1357 mg/L PBTK NA 50% Rat Human +DTXSID1023287 Css NA 0.3672 mg/L PBTK NA 95% Rat Human +DTXSID1023289 Clint 13 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID1023289 Fup 0.056 NA NA Williamson 2020 NA Human Human +DTXSID1023289 Vd NA 3.121 L/kg 1compartment NA NA Human Human +DTXSID1023289 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID1023289 TK.Half.Life NA 124 hours 1compartment NA NA Human Human +DTXSID1023289 Css NA 4.723 mg/L 3compartmentss NA 50% Human Human +DTXSID1023289 Css NA 29.83 mg/L 3compartmentss NA 95% Human Human +DTXSID1023289 Css NA 3.296 mg/L PBTK NA 50% Human Human +DTXSID1023289 Css NA 20.3 mg/L PBTK NA 95% Human Human +DTXSID1023289 Clint 13 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID1023289 Fup 0.056 NA NA Williamson 2020 NA Rat Human +DTXSID1023289 Vd NA 2.338 L/kg 1compartment NA NA Rat Human +DTXSID1023289 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID1023289 TK.Half.Life NA 16.53 hours 1compartment NA NA Rat Human +DTXSID1023289 Css NA 0.6077 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023289 Css NA 3.526 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023289 Css NA 0.4202 mg/L PBTK NA 50% Rat Human +DTXSID1023289 Css NA 2.366 mg/L PBTK NA 95% Rat Human +DTXSID1023310 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023310 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023310 Vd NA 0.3281 L/kg 1compartment NA NA Human Human DTXSID1023310 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023310 TK.Half.Life NA 3.733 hours 1compartment NA NA Human Human -DTXSID1023310 Css NA 1.326 mg/L 3compartmentss NA 50% Human Human -DTXSID1023310 Css NA 7.966 mg/L 3compartmentss NA 95% Human Human -DTXSID1023310 Css NA 0.9326 mg/L PBTK NA 50% Human Human -DTXSID1023310 Css NA 4.85 mg/L PBTK NA 95% Human Human -DTXSID1023310 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023310 Fup NA 0.6496 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023310 Vd NA 0.3968 L/kg 1compartment NA NA Rat Human +DTXSID1023310 TK.Half.Life NA 4.376 hours 1compartment NA NA Human Human +DTXSID1023310 Css NA 0.8859 mg/L 3compartmentss NA 50% Human Human +DTXSID1023310 Css NA 4.493 mg/L 3compartmentss NA 95% Human Human +DTXSID1023310 Css NA 0.6048 mg/L PBTK NA 50% Human Human +DTXSID1023310 Css NA 2.719 mg/L PBTK NA 95% Human Human +DTXSID1023310 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023310 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023310 Vd NA 0.3458 L/kg 1compartment NA NA Rat Human DTXSID1023310 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023310 TK.Half.Life NA 1.347 hours 1compartment NA NA Rat Human -DTXSID1023310 Css NA 0.352 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023310 Css NA 1.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023310 Css NA 0.2358 mg/L PBTK NA 50% Rat Human -DTXSID1023310 Css NA 1.064 mg/L PBTK NA 95% Rat Human -DTXSID1023314 Clint NA 4.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023314 Fup NA 0.1646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023314 Vd NA 1.641 L/kg 1compartment NA NA Human Human +DTXSID1023310 TK.Half.Life NA 1.572 hours 1compartment NA NA Rat Human +DTXSID1023310 Css NA 0.004882 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023310 Css NA 0.02422 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023310 Css NA 0.003158 mg/L PBTK NA 50% Rat Human +DTXSID1023310 Css NA 0.01412 mg/L PBTK NA 95% Rat Human +DTXSID1023314 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023314 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023314 Vd NA 1.224 L/kg 1compartment NA NA Human Human DTXSID1023314 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023314 TK.Half.Life NA 10.69 hours 1compartment NA NA Human Human -DTXSID1023314 Css NA 0.7638 mg/L 3compartmentss NA 50% Human Human -DTXSID1023314 Css NA 4.119 mg/L 3compartmentss NA 95% Human Human -DTXSID1023314 Css NA 0.5376 mg/L PBTK NA 50% Human Human -DTXSID1023314 Css NA 2.705 mg/L PBTK NA 95% Human Human -DTXSID1023314 Clint NA 4.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023314 Fup NA 0.1646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023314 Vd NA 1.296 L/kg 1compartment NA NA Rat Human +DTXSID1023314 TK.Half.Life NA 3.287 hours 1compartment NA NA Human Human +DTXSID1023314 Css NA 0.2339 mg/L 3compartmentss NA 50% Human Human +DTXSID1023314 Css NA 1.423 mg/L 3compartmentss NA 95% Human Human +DTXSID1023314 Css NA 0.1764 mg/L PBTK NA 50% Human Human +DTXSID1023314 Css NA 0.9691 mg/L PBTK NA 95% Human Human +DTXSID1023314 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023314 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023314 Vd NA 1.047 L/kg 1compartment NA NA Rat Human DTXSID1023314 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023314 TK.Half.Life NA 4.053 hours 1compartment NA NA Rat Human -DTXSID1023314 Css NA 0.3853 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023314 Css NA 1.497 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023314 Css NA 0.2612 mg/L PBTK NA 50% Rat Human -DTXSID1023314 Css NA 0.9245 mg/L PBTK NA 95% Rat Human -DTXSID1023316 Clint NA 1.409 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1023314 TK.Half.Life NA 1.514 hours 1compartment NA NA Rat Human +DTXSID1023314 Css NA 0.02724 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023314 Css NA 0.1256 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023314 Css NA 0.0206 mg/L PBTK NA 50% Rat Human +DTXSID1023314 Css NA 0.08326 mg/L PBTK NA 95% Rat Human +DTXSID1023316 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1023316 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1023316 Vd NA 0.5318 L/kg 1compartment NA NA Human Human +DTXSID1023316 Vd NA 0.5664 L/kg 1compartment NA NA Human Human DTXSID1023316 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023316 TK.Half.Life NA 1.58 hours 1compartment NA NA Human Human -DTXSID1023316 Css NA 0.3352 mg/L 3compartmentss NA 50% Human Human -DTXSID1023316 Css NA 2.241 mg/L 3compartmentss NA 95% Human Human -DTXSID1023316 Css NA 0.2567 mg/L PBTK NA 50% Human Human -DTXSID1023316 Css NA 1.437 mg/L PBTK NA 95% Human Human -DTXSID1023316 Clint NA 1.409 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1023316 TK.Half.Life NA 0.7523 hours 1compartment NA NA Human Human +DTXSID1023316 Css NA 0.04732 mg/L 3compartmentss NA 50% Human Human +DTXSID1023316 Css NA 0.5051 mg/L 3compartmentss NA 95% Human Human +DTXSID1023316 Css NA 0.0368 mg/L PBTK NA 50% Human Human +DTXSID1023316 Css NA 0.3349 mg/L PBTK NA 95% Human Human +DTXSID1023316 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1023316 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1023316 Vd NA 0.5508 L/kg 1compartment NA NA Rat Human +DTXSID1023316 Vd NA 0.5822 L/kg 1compartment NA NA Rat Human DTXSID1023316 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023316 TK.Half.Life NA 0.8298 hours 1compartment NA NA Rat Human -DTXSID1023316 Css NA 0.1376 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023316 Css NA 0.9005 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023316 Css NA 0.1024 mg/L PBTK NA 50% Rat Human -DTXSID1023316 Css NA 0.5262 mg/L PBTK NA 95% Rat Human -DTXSID1023362 Clint NA 6.626 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023362 Fup NA 0.3524 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023362 Vd NA 0.6973 L/kg 1compartment NA NA Human Human +DTXSID1023316 TK.Half.Life NA 0.4094 hours 1compartment NA NA Rat Human +DTXSID1023316 Css NA 0.0004157 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023316 Css NA 0.004318 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023316 Css NA 0.0003144 mg/L PBTK NA 50% Rat Human +DTXSID1023316 Css NA 0.002655 mg/L PBTK NA 95% Rat Human +DTXSID1023318 Clint 26 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID1023318 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1023318 Vd NA 2.923 L/kg 1compartment NA NA Human Human +DTXSID1023318 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1023318 TK.Half.Life NA 22.78 hours 1compartment NA NA Human Human +DTXSID1023318 Css NA 0.9234 mg/L 3compartmentss NA 50% Human Human +DTXSID1023318 Css NA 6.7 mg/L 3compartmentss NA 95% Human Human +DTXSID1023318 Css NA 0.6319 mg/L PBTK NA 50% Human Human +DTXSID1023318 Css NA 4.362 mg/L PBTK NA 95% Human Human +DTXSID1023318 Clint 26 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID1023318 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1023318 Vd NA 2.2 L/kg 1compartment NA NA Rat Human +DTXSID1023318 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1023318 TK.Half.Life NA 4.365 hours 1compartment NA NA Rat Human +DTXSID1023318 Css NA 0.1185 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023318 Css NA 0.688 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023318 Css NA 0.07989 mg/L PBTK NA 50% Rat Human +DTXSID1023318 Css NA 0.4453 mg/L PBTK NA 95% Rat Human +DTXSID1023362 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023362 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023362 Vd NA 0.6518 L/kg 1compartment NA NA Human Human DTXSID1023362 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023362 TK.Half.Life NA 1.511 hours 1compartment NA NA Human Human -DTXSID1023362 Css NA 0.1834 mg/L 3compartmentss NA 50% Human Human -DTXSID1023362 Css NA 1.193 mg/L 3compartmentss NA 95% Human Human -DTXSID1023362 Css NA 0.1338 mg/L PBTK NA 50% Human Human -DTXSID1023362 Css NA 0.7821 mg/L PBTK NA 95% Human Human -DTXSID1023362 Clint NA 6.626 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023362 Fup NA 0.3524 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023362 Vd NA 0.6739 L/kg 1compartment NA NA Rat Human +DTXSID1023362 TK.Half.Life NA 1.607 hours 1compartment NA NA Human Human +DTXSID1023362 Css NA 0.2128 mg/L 3compartmentss NA 50% Human Human +DTXSID1023362 Css NA 1.332 mg/L 3compartmentss NA 95% Human Human +DTXSID1023362 Css NA 0.1517 mg/L PBTK NA 50% Human Human +DTXSID1023362 Css NA 0.869 mg/L PBTK NA 95% Human Human +DTXSID1023362 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023362 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023362 Vd NA 0.6287 L/kg 1compartment NA NA Rat Human DTXSID1023362 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023362 TK.Half.Life NA 0.8195 hours 1compartment NA NA Rat Human -DTXSID1023362 Css NA 0.093 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023362 Css NA 0.4518 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023362 Css NA 0.0651 mg/L PBTK NA 50% Rat Human -DTXSID1023362 Css NA 0.2824 mg/L PBTK NA 95% Rat Human -DTXSID1023364 Clint NA 1212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023364 Fup NA 0.0387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023364 Vd NA 1.782 L/kg 1compartment NA NA Human Human +DTXSID1023362 TK.Half.Life NA 0.8786 hours 1compartment NA NA Rat Human +DTXSID1023362 Css NA 0.02523 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023362 Css NA 0.1179 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023362 Css NA 0.01776 mg/L PBTK NA 50% Rat Human +DTXSID1023362 Css NA 0.07495 mg/L PBTK NA 95% Rat Human +DTXSID1023364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023364 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023364 Vd NA 2.067 L/kg 1compartment NA NA Human Human DTXSID1023364 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023364 TK.Half.Life NA 1.723 hours 1compartment NA NA Human Human -DTXSID1023364 Css NA 0.0161 mg/L 3compartmentss NA 50% Human Human -DTXSID1023364 Css NA 0.1414 mg/L 3compartmentss NA 95% Human Human -DTXSID1023364 Css NA 0.01036 mg/L PBTK NA 50% Human Human -DTXSID1023364 Css NA 0.08824 mg/L PBTK NA 95% Human Human -DTXSID1023364 Clint NA 1212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023364 Fup NA 0.0387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023364 Vd NA 1.332 L/kg 1compartment NA NA Rat Human +DTXSID1023364 TK.Half.Life NA 6.945 hours 1compartment NA NA Human Human +DTXSID1023364 Css NA 0.3167 mg/L 3compartmentss NA 50% Human Human +DTXSID1023364 Css NA 2.337 mg/L 3compartmentss NA 95% Human Human +DTXSID1023364 Css NA 0.2159 mg/L PBTK NA 50% Human Human +DTXSID1023364 Css NA 1.512 mg/L PBTK NA 95% Human Human +DTXSID1023364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023364 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023364 Vd NA 1.565 L/kg 1compartment NA NA Rat Human DTXSID1023364 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023364 TK.Half.Life NA 0.5696 hours 1compartment NA NA Rat Human -DTXSID1023364 Css NA 0.00919 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023364 Css NA 0.06703 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023364 Css NA 0.005582 mg/L PBTK NA 50% Rat Human -DTXSID1023364 Css NA 0.03873 mg/L PBTK NA 95% Rat Human -DTXSID1023368 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023368 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023368 Vd NA 0.3274 L/kg 1compartment NA NA Human Human -DTXSID1023368 Days.Css NA 87 Days PBTK NA NA Human Human -DTXSID1023368 TK.Half.Life NA 346.4 hours 1compartment NA NA Human Human -DTXSID1023368 Css NA 181.9 mg/L 3compartmentss NA 50% Human Human -DTXSID1023368 Css NA 1094 mg/L 3compartmentss NA 95% Human Human -DTXSID1023368 Css NA 107.5 mg/L PBTK NA 50% Human Human -DTXSID1023368 Css NA 642.2 mg/L PBTK NA 95% Human Human -DTXSID1023368 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023368 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023368 Vd NA 0.2674 L/kg 1compartment NA NA Rat Human -DTXSID1023368 Days.Css NA 20 Days PBTK NA NA Rat Human -DTXSID1023368 TK.Half.Life NA 95.4 hours 1compartment NA NA Rat Human -DTXSID1023368 Css NA 51.85 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023368 Css NA 277.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023368 Css NA 28.44 mg/L PBTK NA 50% Rat Human -DTXSID1023368 Css NA 150.1 mg/L PBTK NA 95% Rat Human -DTXSID1023441 Clint NA 51.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1023364 TK.Half.Life NA 2.249 hours 1compartment NA NA Rat Human +DTXSID1023364 Css NA 0.01586 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023364 Css NA 0.1238 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023364 Css NA 0.01047 mg/L PBTK NA 50% Rat Human +DTXSID1023364 Css NA 0.07677 mg/L PBTK NA 95% Rat Human +DTXSID1023368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023368 Fup 0.0267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023368 Vd NA 0.621 L/kg 1compartment NA NA Human Human +DTXSID1023368 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1023368 TK.Half.Life NA 12.96 hours 1compartment NA NA Human Human +DTXSID1023368 Css NA 3.562 mg/L 3compartmentss NA 50% Human Human +DTXSID1023368 Css NA 30.33 mg/L 3compartmentss NA 95% Human Human +DTXSID1023368 Css NA 2.192 mg/L PBTK NA 50% Human Human +DTXSID1023368 Css NA 18.03 mg/L PBTK NA 95% Human Human +DTXSID1023368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023368 Fup 0.0267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023368 Vd NA 0.4896 L/kg 1compartment NA NA Rat Human +DTXSID1023368 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1023368 TK.Half.Life NA 6.25 hours 1compartment NA NA Rat Human +DTXSID1023368 Css NA 0.4339 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023368 Css NA 2.884 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023368 Css NA 0.2589 mg/L PBTK NA 50% Rat Human +DTXSID1023368 Css NA 1.64 mg/L PBTK NA 95% Rat Human +DTXSID10233968 Clint 6.76 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10233968 Fup 0.0604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10233968 Vd NA 0.5886 L/kg 1compartment NA NA Human Human +DTXSID10233968 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10233968 TK.Half.Life NA 5.514 hours 1compartment NA NA Human Human +DTXSID10233968 Css NA 1.47 mg/L 3compartmentss NA 50% Human Human +DTXSID10233968 Css NA 10.07 mg/L 3compartmentss NA 95% Human Human +DTXSID10233968 Css NA 0.9065 mg/L PBTK NA 50% Human Human +DTXSID10233968 Css NA 5.912 mg/L PBTK NA 95% Human Human +DTXSID10233968 Clint 6.76 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10233968 Fup 0.0604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10233968 Vd NA 0.4781 L/kg 1compartment NA NA Rat Human +DTXSID10233968 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10233968 TK.Half.Life NA 2.718 hours 1compartment NA NA Rat Human +DTXSID10233968 Css NA 0.1826 mg/L 3compartmentss NA 50% Rat Human +DTXSID10233968 Css NA 0.9174 mg/L 3compartmentss NA 95% Rat Human +DTXSID10233968 Css NA 0.1088 mg/L PBTK NA 50% Rat Human +DTXSID10233968 Css NA 0.5292 mg/L PBTK NA 95% Rat Human +DTXSID1023441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1023441 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1023441 Vd NA 2.929 L/kg 1compartment NA NA Human Human +DTXSID1023441 Vd NA 2.297 L/kg 1compartment NA NA Human Human DTXSID1023441 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023441 TK.Half.Life NA 13.63 hours 1compartment NA NA Human Human -DTXSID1023441 Css NA 0.5115 mg/L 3compartmentss NA 50% Human Human -DTXSID1023441 Css NA 3.097 mg/L 3compartmentss NA 95% Human Human -DTXSID1023441 Css NA 0.3546 mg/L PBTK NA 50% Human Human -DTXSID1023441 Css NA 2.068 mg/L PBTK NA 95% Human Human -DTXSID1023441 Clint NA 51.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1023441 TK.Half.Life NA 11.34 hours 1compartment NA NA Human Human +DTXSID1023441 Css NA 0.5861 mg/L 3compartmentss NA 50% Human Human +DTXSID1023441 Css NA 3.925 mg/L 3compartmentss NA 95% Human Human +DTXSID1023441 Css NA 0.3944 mg/L PBTK NA 50% Human Human +DTXSID1023441 Css NA 2.563 mg/L PBTK NA 95% Human Human +DTXSID1023441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1023441 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1023441 Vd NA 2.198 L/kg 1compartment NA NA Rat Human +DTXSID1023441 Vd NA 1.726 L/kg 1compartment NA NA Rat Human DTXSID1023441 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023441 TK.Half.Life NA 2.671 hours 1compartment NA NA Rat Human -DTXSID1023441 Css NA 0.2813 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023441 Css NA 1.489 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023441 Css NA 0.1857 mg/L PBTK NA 50% Rat Human -DTXSID1023441 Css NA 0.9513 mg/L PBTK NA 95% Rat Human -DTXSID1023495 Clint NA 1.985 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1023441 TK.Half.Life NA 3.266 hours 1compartment NA NA Rat Human +DTXSID1023441 Css NA 0.07556 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023441 Css NA 0.3964 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023441 Css NA 0.05022 mg/L PBTK NA 50% Rat Human +DTXSID1023441 Css NA 0.2549 mg/L PBTK NA 95% Rat Human +DTXSID1023495 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1023495 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1023495 Vd NA 0.8804 L/kg 1compartment NA NA Human Human +DTXSID1023495 Vd NA 0.9139 L/kg 1compartment NA NA Human Human DTXSID1023495 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023495 TK.Half.Life NA 1.591 hours 1compartment NA NA Human Human -DTXSID1023495 Css NA 0.1865 mg/L 3compartmentss NA 50% Human Human -DTXSID1023495 Css NA 1.427 mg/L 3compartmentss NA 95% Human Human -DTXSID1023495 Css NA 0.1662 mg/L PBTK NA 50% Human Human -DTXSID1023495 Css NA 1.022 mg/L PBTK NA 95% Human Human -DTXSID1023495 Clint NA 1.985 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1023495 TK.Half.Life NA 0.9057 hours 1compartment NA NA Human Human +DTXSID1023495 Css NA 0.06588 mg/L 3compartmentss NA 50% Human Human +DTXSID1023495 Css NA 0.6647 mg/L 3compartmentss NA 95% Human Human +DTXSID1023495 Css NA 0.05956 mg/L PBTK NA 50% Human Human +DTXSID1023495 Css NA 0.4967 mg/L PBTK NA 95% Human Human +DTXSID1023495 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1023495 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1023495 Vd NA 0.8924 L/kg 1compartment NA NA Rat Human +DTXSID1023495 Vd NA 0.925 L/kg 1compartment NA NA Rat Human DTXSID1023495 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023495 TK.Half.Life NA 0.8312 hours 1compartment NA NA Rat Human -DTXSID1023495 Css NA 0.07667 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023495 Css NA 0.5184 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023495 Css NA 0.06847 mg/L PBTK NA 50% Rat Human -DTXSID1023495 Css NA 0.3269 mg/L PBTK NA 95% Rat Human -DTXSID1023497 Clint NA 0.4978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023497 Fup NA 0.0175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023497 Vd NA 0.2426 L/kg 1compartment NA NA Human Human -DTXSID1023497 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID1023497 TK.Half.Life NA 48.95 hours 1compartment NA NA Human Human -DTXSID1023497 Css NA 33.84 mg/L 3compartmentss NA 50% Human Human -DTXSID1023497 Css NA 222.8 mg/L 3compartmentss NA 95% Human Human -DTXSID1023497 Css NA 20.26 mg/L PBTK NA 50% Human Human -DTXSID1023497 Css NA 130.4 mg/L PBTK NA 95% Human Human -DTXSID1023497 Clint NA 0.4978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023497 Fup NA 0.0175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023497 Vd NA 0.232 L/kg 1compartment NA NA Rat Human -DTXSID1023497 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID1023497 TK.Half.Life NA 20.8 hours 1compartment NA NA Rat Human -DTXSID1023497 Css NA 12.78 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023497 Css NA 74.81 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023497 Css NA 7.102 mg/L PBTK NA 50% Rat Human -DTXSID1023497 Css NA 40.59 mg/L PBTK NA 95% Rat Human +DTXSID1023495 TK.Half.Life NA 0.4794 hours 1compartment NA NA Rat Human +DTXSID1023495 Css NA 0.007244 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023495 Css NA 0.05566 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023495 Css NA 0.006756 mg/L PBTK NA 50% Rat Human +DTXSID1023495 Css NA 0.03908 mg/L PBTK NA 95% Rat Human +DTXSID1023497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023497 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023497 Vd NA 0.3378 L/kg 1compartment NA NA Human Human +DTXSID1023497 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1023497 TK.Half.Life NA 1.857 hours 1compartment NA NA Human Human +DTXSID1023497 Css NA 0.837 mg/L 3compartmentss NA 50% Human Human +DTXSID1023497 Css NA 7.839 mg/L 3compartmentss NA 95% Human Human +DTXSID1023497 Css NA 0.5193 mg/L PBTK NA 50% Human Human +DTXSID1023497 Css NA 4.696 mg/L PBTK NA 95% Human Human +DTXSID1023497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023497 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023497 Vd NA 0.3194 L/kg 1compartment NA NA Rat Human +DTXSID1023497 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1023497 TK.Half.Life NA 1.123 hours 1compartment NA NA Rat Human +DTXSID1023497 Css NA 0.1128 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023497 Css NA 0.7902 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023497 Css NA 0.06732 mg/L PBTK NA 50% Rat Human +DTXSID1023497 Css NA 0.4561 mg/L PBTK NA 95% Rat Human +DTXSID10234975 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10234975 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10234975 Vd NA 0.5871 L/kg 1compartment NA NA Human Human +DTXSID10234975 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10234975 TK.Half.Life NA 3.455 hours 1compartment NA NA Human Human +DTXSID10234975 Css NA 0.8088 mg/L 3compartmentss NA 50% Human Human +DTXSID10234975 Css NA 5.533 mg/L 3compartmentss NA 95% Human Human +DTXSID10234975 Css NA 0.5143 mg/L PBTK NA 50% Human Human +DTXSID10234975 Css NA 3.338 mg/L PBTK NA 95% Human Human +DTXSID10234975 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10234975 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10234975 Vd NA 0.5008 L/kg 1compartment NA NA Rat Human +DTXSID10234975 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10234975 TK.Half.Life NA 1.755 hours 1compartment NA NA Rat Human +DTXSID10234975 Css NA 0.09972 mg/L 3compartmentss NA 50% Rat Human +DTXSID10234975 Css NA 0.519 mg/L 3compartmentss NA 95% Rat Human +DTXSID10234975 Css NA 0.06172 mg/L PBTK NA 50% Rat Human +DTXSID10234975 Css NA 0.3029 mg/L PBTK NA 95% Rat Human DTXSID1023524 Clint 11 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID1023524 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1023524 Vd NA 5.362 L/kg 1compartment NA NA Human Human DTXSID1023524 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1023524 TK.Half.Life NA 6.279 hours 1compartment NA NA Human Human -DTXSID1023524 Css NA 0.05079 mg/L 3compartmentss NA 50% Human Human -DTXSID1023524 Css NA 0.4139 mg/L 3compartmentss NA 95% Human Human -DTXSID1023524 Css NA 0.07276 mg/L PBTK NA 50% Human Human -DTXSID1023524 Css NA 0.459 mg/L PBTK NA 95% Human Human +DTXSID1023524 Css NA 0.04882 mg/L 3compartmentss NA 50% Human Human +DTXSID1023524 Css NA 0.4108 mg/L 3compartmentss NA 95% Human Human +DTXSID1023524 Css NA 0.07032 mg/L PBTK NA 50% Human Human +DTXSID1023524 Css NA 0.4542 mg/L PBTK NA 95% Human Human DTXSID1023524 Clint 11 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID1023524 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1023524 Vd NA 5.297 L/kg 1compartment NA NA Rat Human DTXSID1023524 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1023524 TK.Half.Life NA 3.093 hours 1compartment NA NA Rat Human -DTXSID1023524 Css NA 0.0263 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023524 Css NA 0.1634 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023524 Css NA 0.03847 mg/L PBTK NA 50% Rat Human -DTXSID1023524 Css NA 0.1824 mg/L PBTK NA 95% Rat Human -DTXSID1023572 Clint NA 9.816 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023572 Fup NA 0.0074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023572 Vd NA 0.1876 L/kg 1compartment NA NA Human Human +DTXSID1023524 Css NA 0.005743 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023524 Css NA 0.03658 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023524 Css NA 0.008775 mg/L PBTK NA 50% Rat Human +DTXSID1023524 Css NA 0.04325 mg/L PBTK NA 95% Rat Human +DTXSID1023526 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023526 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023526 Vd NA 4.577 L/kg 1compartment NA NA Human Human +DTXSID1023526 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1023526 TK.Half.Life NA 2.707 hours 1compartment NA NA Human Human +DTXSID1023526 Css NA 0.01432 mg/L 3compartmentss NA 50% Human Human +DTXSID1023526 Css NA 0.1536 mg/L 3compartmentss NA 95% Human Human +DTXSID1023526 Css NA 0.02324 mg/L PBTK NA 50% Human Human +DTXSID1023526 Css NA 0.1768 mg/L PBTK NA 95% Human Human +DTXSID1023526 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023526 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023526 Vd NA 4.574 L/kg 1compartment NA NA Rat Human +DTXSID1023526 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1023526 TK.Half.Life NA 1.472 hours 1compartment NA NA Rat Human +DTXSID1023526 Css NA 0.001709 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023526 Css NA 0.01488 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023526 Css NA 0.002957 mg/L PBTK NA 50% Rat Human +DTXSID1023526 Css NA 0.01709 mg/L PBTK NA 95% Rat Human +DTXSID1023572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023572 Fup 0.03 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023572 Vd NA 0.2489 L/kg 1compartment NA NA Human Human DTXSID1023572 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023572 TK.Half.Life NA 9.491 hours 1compartment NA NA Human Human -DTXSID1023572 Css NA 9.698 mg/L 3compartmentss NA 50% Human Human -DTXSID1023572 Css NA 83.76 mg/L 3compartmentss NA 95% Human Human -DTXSID1023572 Css NA 5.682 mg/L PBTK NA 50% Human Human -DTXSID1023572 Css NA 48.36 mg/L PBTK NA 95% Human Human -DTXSID1023572 Clint NA 9.816 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023572 Fup NA 0.0074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023572 Vd NA 0.1791 L/kg 1compartment NA NA Rat Human +DTXSID1023572 TK.Half.Life NA 1.656 hours 1compartment NA NA Human Human +DTXSID1023572 Css NA 1.07 mg/L 3compartmentss NA 50% Human Human +DTXSID1023572 Css NA 10.14 mg/L 3compartmentss NA 95% Human Human +DTXSID1023572 Css NA 0.635 mg/L PBTK NA 50% Human Human +DTXSID1023572 Css NA 6.029 mg/L PBTK NA 95% Human Human +DTXSID1023572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023572 Fup 0.03 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023572 Vd NA 0.231 L/kg 1compartment NA NA Rat Human DTXSID1023572 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023572 TK.Half.Life NA 5.955 hours 1compartment NA NA Rat Human -DTXSID1023572 Css NA 5.252 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023572 Css NA 37 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023572 Css NA 2.854 mg/L PBTK NA 50% Rat Human -DTXSID1023572 Css NA 20.04 mg/L PBTK NA 95% Rat Human -DTXSID1023576 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023576 Fup NA 0.0553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023576 Vd NA 0.2088 L/kg 1compartment NA NA Human Human -DTXSID1023576 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1023576 TK.Half.Life NA 24.43 hours 1compartment NA NA Human Human -DTXSID1023576 Css NA 19.62 mg/L 3compartmentss NA 50% Human Human -DTXSID1023576 Css NA 92.26 mg/L 3compartmentss NA 95% Human Human -DTXSID1023576 Css NA 11.63 mg/L PBTK NA 50% Human Human -DTXSID1023576 Css NA 52.94 mg/L PBTK NA 95% Human Human -DTXSID1023576 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023576 Fup NA 0.0553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023576 Vd NA 0.2064 L/kg 1compartment NA NA Rat Human +DTXSID1023572 TK.Half.Life NA 0.9915 hours 1compartment NA NA Rat Human +DTXSID1023572 Css NA 0.1415 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023572 Css NA 1.081 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023572 Css NA 0.08133 mg/L PBTK NA 50% Rat Human +DTXSID1023572 Css NA 0.6086 mg/L PBTK NA 95% Rat Human +DTXSID1023576 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023576 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023576 Vd NA 0.2222 L/kg 1compartment NA NA Human Human +DTXSID1023576 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1023576 TK.Half.Life NA 12.39 hours 1compartment NA NA Human Human +DTXSID1023576 Css NA 7.364 mg/L 3compartmentss NA 50% Human Human +DTXSID1023576 Css NA 34.53 mg/L 3compartmentss NA 95% Human Human +DTXSID1023576 Css NA 4.461 mg/L PBTK NA 50% Human Human +DTXSID1023576 Css NA 19.97 mg/L PBTK NA 95% Human Human +DTXSID1023576 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023576 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023576 Vd NA 0.2247 L/kg 1compartment NA NA Rat Human DTXSID1023576 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023576 TK.Half.Life NA 8.227 hours 1compartment NA NA Rat Human -DTXSID1023576 Css NA 5.591 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023576 Css NA 22.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023576 Css NA 3.101 mg/L PBTK NA 50% Rat Human -DTXSID1023576 Css NA 12.15 mg/L PBTK NA 95% Rat Human -DTXSID1023603 Clint NA 2.557 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023603 Fup NA 0.8757 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023603 Vd NA 2.901 L/kg 1compartment NA NA Human Human -DTXSID1023603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023603 TK.Half.Life NA 4.874 hours 1compartment NA NA Human Human -DTXSID1023603 Css NA 0.1376 mg/L 3compartmentss NA 50% Human Human -DTXSID1023603 Css NA 1.152 mg/L 3compartmentss NA 95% Human Human -DTXSID1023603 Css NA 0.154 mg/L PBTK NA 50% Human Human -DTXSID1023603 Css NA 0.9084 mg/L PBTK NA 95% Human Human -DTXSID1023603 Clint NA 2.557 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023603 Fup NA 0.8757 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023603 Vd NA 2.951 L/kg 1compartment NA NA Rat Human +DTXSID1023576 TK.Half.Life NA 4.271 hours 1compartment NA NA Rat Human +DTXSID1023576 Css NA 0.1372 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023576 Css NA 0.9061 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023576 Css NA 0.07852 mg/L PBTK NA 50% Rat Human +DTXSID1023576 Css NA 0.5137 mg/L PBTK NA 95% Rat Human +DTXSID1023603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023603 Fup 0.523 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023603 Vd NA 1.553 L/kg 1compartment NA NA Human Human +DTXSID1023603 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1023603 TK.Half.Life NA 19.23 hours 1compartment NA NA Human Human +DTXSID1023603 Css NA 1.156 mg/L 3compartmentss NA 50% Human Human +DTXSID1023603 Css NA 7.326 mg/L 3compartmentss NA 95% Human Human +DTXSID1023603 Css NA 1.049 mg/L PBTK NA 50% Human Human +DTXSID1023603 Css NA 4.878 mg/L PBTK NA 95% Human Human +DTXSID1023603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023603 Fup 0.523 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023603 Vd NA 1.57 L/kg 1compartment NA NA Rat Human DTXSID1023603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023603 TK.Half.Life NA 2.661 hours 1compartment NA NA Rat Human -DTXSID1023603 Css NA 0.058 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023603 Css NA 0.4399 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023603 Css NA 0.06635 mg/L PBTK NA 50% Rat Human -DTXSID1023603 Css NA 0.3051 mg/L PBTK NA 95% Rat Human +DTXSID1023603 TK.Half.Life NA 6.62 hours 1compartment NA NA Rat Human +DTXSID1023603 Css NA 0.07056 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023603 Css NA 0.4078 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023603 Css NA 0.06451 mg/L PBTK NA 50% Rat Human +DTXSID1023603 Css NA 0.2635 mg/L PBTK NA 95% Rat Human DTXSID1023605 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1023605 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1023605 Vd NA 0.4599 L/kg 1compartment NA NA Human Human +DTXSID1023605 Vd NA 0.4034 L/kg 1compartment NA NA Human Human DTXSID1023605 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023605 TK.Half.Life NA 1.017 hours 1compartment NA NA Human Human -DTXSID1023605 Css NA 0.2248 mg/L 3compartmentss NA 50% Human Human -DTXSID1023605 Css NA 1.737 mg/L 3compartmentss NA 95% Human Human -DTXSID1023605 Css NA 0.1638 mg/L PBTK NA 50% Human Human -DTXSID1023605 Css NA 1.094 mg/L PBTK NA 95% Human Human +DTXSID1023605 TK.Half.Life NA 0.8548 hours 1compartment NA NA Human Human +DTXSID1023605 Css NA 0.2089 mg/L 3compartmentss NA 50% Human Human +DTXSID1023605 Css NA 1.586 mg/L 3compartmentss NA 95% Human Human +DTXSID1023605 Css NA 0.1481 mg/L PBTK NA 50% Human Human +DTXSID1023605 Css NA 1.004 mg/L PBTK NA 95% Human Human DTXSID1023605 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1023605 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1023605 Vd NA 0.4722 L/kg 1compartment NA NA Rat Human +DTXSID1023605 Vd NA 0.4221 L/kg 1compartment NA NA Rat Human DTXSID1023605 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023605 TK.Half.Life NA 0.5581 hours 1compartment NA NA Rat Human -DTXSID1023605 Css NA 0.1033 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023605 Css NA 0.7204 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023605 Css NA 0.07281 mg/L PBTK NA 50% Rat Human -DTXSID1023605 Css NA 0.4167 mg/L PBTK NA 95% Rat Human -DTXSID1023607 Clint NA 9.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023607 Fup NA 0.0735 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023607 Vd NA 0.2347 L/kg 1compartment NA NA Human Human +DTXSID1023605 TK.Half.Life NA 0.478 hours 1compartment NA NA Rat Human +DTXSID1023605 Css NA 0.0223 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023605 Css NA 0.146 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023605 Css NA 0.01586 mg/L PBTK NA 50% Rat Human +DTXSID1023605 Css NA 0.08832 mg/L PBTK NA 95% Rat Human +DTXSID1023607 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023607 Fup 0.0705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023607 Vd NA 0.232 L/kg 1compartment NA NA Human Human DTXSID1023607 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023607 TK.Half.Life NA 1.491 hours 1compartment NA NA Human Human -DTXSID1023607 Css NA 0.9996 mg/L 3compartmentss NA 50% Human Human -DTXSID1023607 Css NA 7.093 mg/L 3compartmentss NA 95% Human Human -DTXSID1023607 Css NA 0.601 mg/L PBTK NA 50% Human Human -DTXSID1023607 Css NA 4.172 mg/L PBTK NA 95% Human Human -DTXSID1023607 Clint NA 9.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023607 Fup NA 0.0735 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023607 Vd NA 0.2317 L/kg 1compartment NA NA Rat Human +DTXSID1023607 TK.Half.Life NA 2.059 hours 1compartment NA NA Human Human +DTXSID1023607 Css NA 1.226 mg/L 3compartmentss NA 50% Human Human +DTXSID1023607 Css NA 7.724 mg/L 3compartmentss NA 95% Human Human +DTXSID1023607 Css NA 0.735 mg/L PBTK NA 50% Human Human +DTXSID1023607 Css NA 4.541 mg/L PBTK NA 95% Human Human +DTXSID1023607 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023607 Fup 0.0705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023607 Vd NA 0.229 L/kg 1compartment NA NA Rat Human DTXSID1023607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023607 TK.Half.Life NA 0.9172 hours 1compartment NA NA Rat Human -DTXSID1023607 Css NA 0.5393 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023607 Css NA 2.772 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023607 Css NA 0.304 mg/L PBTK NA 50% Rat Human -DTXSID1023607 Css NA 1.526 mg/L PBTK NA 95% Rat Human -DTXSID1023609 Clint NA 68.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023609 Fup NA 0.9106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023609 Vd NA 0.4623 L/kg 1compartment NA NA Human Human +DTXSID1023607 TK.Half.Life NA 1.255 hours 1compartment NA NA Rat Human +DTXSID1023607 Css NA 0.05552 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023607 Css NA 0.3925 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023607 Css NA 0.03178 mg/L PBTK NA 50% Rat Human +DTXSID1023607 Css NA 0.2244 mg/L PBTK NA 95% Rat Human +DTXSID1023609 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023609 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023609 Vd NA 0.4094 L/kg 1compartment NA NA Human Human DTXSID1023609 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023609 TK.Half.Life NA 0.3262 hours 1compartment NA NA Human Human -DTXSID1023609 Css NA 0.008865 mg/L 3compartmentss NA 50% Human Human -DTXSID1023609 Css NA 0.09447 mg/L 3compartmentss NA 95% Human Human -DTXSID1023609 Css NA 0.006411 mg/L PBTK NA 50% Human Human -DTXSID1023609 Css NA 0.06137 mg/L PBTK NA 95% Human Human -DTXSID1023609 Clint NA 68.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023609 Fup NA 0.9106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023609 Vd NA 0.4873 L/kg 1compartment NA NA Rat Human +DTXSID1023609 TK.Half.Life NA 3.683 hours 1compartment NA NA Human Human +DTXSID1023609 Css NA 0.6579 mg/L 3compartmentss NA 50% Human Human +DTXSID1023609 Css NA 4.052 mg/L 3compartmentss NA 95% Human Human +DTXSID1023609 Css NA 0.4748 mg/L PBTK NA 50% Human Human +DTXSID1023609 Css NA 2.496 mg/L PBTK NA 95% Human Human +DTXSID1023609 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023609 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023609 Vd NA 0.4306 L/kg 1compartment NA NA Rat Human DTXSID1023609 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023609 TK.Half.Life NA 0.1523 hours 1compartment NA NA Rat Human -DTXSID1023609 Css NA 0.004598 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023609 Css NA 0.04151 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023609 Css NA 0.00326 mg/L PBTK NA 50% Rat Human -DTXSID1023609 Css NA 0.02671 mg/L PBTK NA 95% Rat Human -DTXSID1023730 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023730 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023730 Vd NA 0.6991 L/kg 1compartment NA NA Human Human +DTXSID1023609 TK.Half.Life NA 1.321 hours 1compartment NA NA Rat Human +DTXSID1023609 Css NA 0.003448 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023609 Css NA 0.02284 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023609 Css NA 0.002399 mg/L PBTK NA 50% Rat Human +DTXSID1023609 Css NA 0.01324 mg/L PBTK NA 95% Rat Human +DTXSID1023653 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023653 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1023653 Vd NA 0.3863 L/kg 1compartment NA NA Human Human +DTXSID1023653 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1023653 TK.Half.Life NA 18.1 hours 1compartment NA NA Human Human +DTXSID1023653 Css NA 4.206 mg/L 3compartmentss NA 50% Human Human +DTXSID1023653 Css NA 18.34 mg/L 3compartmentss NA 95% Human Human +DTXSID1023653 Css NA 4.206 mg/L PBTK NA 50% Human Human +DTXSID1023653 Css NA 18.34 mg/L PBTK NA 95% Human Human +DTXSID1023653 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023653 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1023653 Vd NA 0.4352 L/kg 1compartment NA NA Rat Human +DTXSID1023653 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1023653 TK.Half.Life NA 3.862 hours 1compartment NA NA Rat Human +DTXSID1023653 Css NA 0.1284 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023653 Css NA 0.3621 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023653 Css NA 0.1329 mg/L PBTK NA 50% Rat Human +DTXSID1023653 Css NA 0.3749 mg/L PBTK NA 95% Rat Human +DTXSID1023730 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023730 Fup 0.544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023730 Vd NA 0.4631 L/kg 1compartment NA NA Human Human DTXSID1023730 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023730 TK.Half.Life NA 4.524 hours 1compartment NA NA Human Human -DTXSID1023730 Css NA 0.8484 mg/L 3compartmentss NA 50% Human Human -DTXSID1023730 Css NA 5.577 mg/L 3compartmentss NA 95% Human Human -DTXSID1023730 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID1023730 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID1023730 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023730 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023730 Vd NA 0.7474 L/kg 1compartment NA NA Rat Human +DTXSID1023730 TK.Half.Life NA 5.51 hours 1compartment NA NA Human Human +DTXSID1023730 Css NA 1.376 mg/L 3compartmentss NA 50% Human Human +DTXSID1023730 Css NA 8.309 mg/L 3compartmentss NA 95% Human Human +DTXSID1023730 Css NA 1.021 mg/L PBTK NA 50% Human Human +DTXSID1023730 Css NA 5.136 mg/L PBTK NA 95% Human Human +DTXSID1023730 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023730 Fup 0.544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023730 Vd NA 0.4947 L/kg 1compartment NA NA Rat Human DTXSID1023730 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023730 TK.Half.Life NA 1.648 hours 1compartment NA NA Rat Human -DTXSID1023730 Css NA 0.2131 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023730 Css NA 1.339 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023730 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID1023730 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID1023734 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023734 Fup NA 0.5956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023734 Vd NA 0.5819 L/kg 1compartment NA NA Human Human +DTXSID1023730 TK.Half.Life NA 2.005 hours 1compartment NA NA Rat Human +DTXSID1023730 Css NA 0.08557 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023730 Css NA 0.465 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023730 Css NA 0.06251 mg/L PBTK NA 50% Rat Human +DTXSID1023730 Css NA 0.2781 mg/L PBTK NA 95% Rat Human +DTXSID1023734 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023734 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023734 Vd NA 0.6744 L/kg 1compartment NA NA Human Human DTXSID1023734 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023734 TK.Half.Life NA 6.324 hours 1compartment NA NA Human Human -DTXSID1023734 Css NA 1.267 mg/L 3compartmentss NA 50% Human Human -DTXSID1023734 Css NA 8.499 mg/L 3compartmentss NA 95% Human Human -DTXSID1023734 Css NA 0.984 mg/L PBTK NA 50% Human Human -DTXSID1023734 Css NA 5.286 mg/L PBTK NA 95% Human Human -DTXSID1023734 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023734 Fup NA 0.5956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023734 Vd NA 0.607 L/kg 1compartment NA NA Rat Human +DTXSID1023734 TK.Half.Life NA 8.247 hours 1compartment NA NA Human Human +DTXSID1023734 Css NA 1.344 mg/L 3compartmentss NA 50% Human Human +DTXSID1023734 Css NA 7.908 mg/L 3compartmentss NA 95% Human Human +DTXSID1023734 Css NA 1.048 mg/L PBTK NA 50% Human Human +DTXSID1023734 Css NA 5.005 mg/L PBTK NA 95% Human Human +DTXSID1023734 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023734 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023734 Vd NA 0.6753 L/kg 1compartment NA NA Rat Human DTXSID1023734 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023734 TK.Half.Life NA 2.248 hours 1compartment NA NA Rat Human -DTXSID1023734 Css NA 0.3362 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023734 Css NA 2.078 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023734 Css NA 0.249 mg/L PBTK NA 50% Rat Human -DTXSID1023734 Css NA 1.208 mg/L PBTK NA 95% Rat Human -DTXSID1023736 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1023734 TK.Half.Life NA 2.803 hours 1compartment NA NA Rat Human +DTXSID1023734 Css NA 0.08196 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023734 Css NA 0.4346 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023734 Css NA 0.06381 mg/L PBTK NA 50% Rat Human +DTXSID1023734 Css NA 0.2651 mg/L PBTK NA 95% Rat Human +DTXSID1023736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1023736 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1023736 Vd NA 4.574 L/kg 1compartment NA NA Human Human -DTXSID1023736 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID1023736 TK.Half.Life NA 27590 hours 1compartment NA NA Human Human -DTXSID1023736 Css NA 594.8 mg/L 3compartmentss NA 50% Human Human -DTXSID1023736 Css NA 1737 mg/L 3compartmentss NA 95% Human Human -DTXSID1023736 Css NA 475.8 mg/L PBTK NA 50% Human Human -DTXSID1023736 Css NA 1235 mg/L PBTK NA 95% Human Human -DTXSID1023736 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1023736 Vd NA 3.568 L/kg 1compartment NA NA Human Human +DTXSID1023736 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1023736 TK.Half.Life NA 10.67 hours 1compartment NA NA Human Human +DTXSID1023736 Css NA 0.24 mg/L 3compartmentss NA 50% Human Human +DTXSID1023736 Css NA 1.621 mg/L 3compartmentss NA 95% Human Human +DTXSID1023736 Css NA 0.1891 mg/L PBTK NA 50% Human Human +DTXSID1023736 Css NA 1.219 mg/L PBTK NA 95% Human Human +DTXSID1023736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1023736 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1023736 Vd NA 3.511 L/kg 1compartment NA NA Rat Human -DTXSID1023736 Days.Css NA 1998 Days PBTK NA NA Rat Human -DTXSID1023736 TK.Half.Life NA 1745 hours 1compartment NA NA Rat Human -DTXSID1023736 Css NA 158.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023736 Css NA 370 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023736 Css NA 123.3 mg/L PBTK NA 50% Rat Human -DTXSID1023736 Css NA 244 mg/L PBTK NA 95% Rat Human +DTXSID1023736 Vd NA 2.862 L/kg 1compartment NA NA Rat Human +DTXSID1023736 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1023736 TK.Half.Life NA 2.147 hours 1compartment NA NA Rat Human +DTXSID1023736 Css NA 0.0307 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023736 Css NA 0.1724 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023736 Css NA 0.02442 mg/L PBTK NA 50% Rat Human +DTXSID1023736 Css NA 0.1312 mg/L PBTK NA 95% Rat Human +DTXSID10237885 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10237885 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10237885 Vd NA 1.398 L/kg 1compartment NA NA Human Human +DTXSID10237885 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10237885 TK.Half.Life NA 5.874 hours 1compartment NA NA Human Human +DTXSID10237885 Css NA 0.4475 mg/L 3compartmentss NA 50% Human Human +DTXSID10237885 Css NA 3.237 mg/L 3compartmentss NA 95% Human Human +DTXSID10237885 Css NA 0.3396 mg/L PBTK NA 50% Human Human +DTXSID10237885 Css NA 2.118 mg/L PBTK NA 95% Human Human +DTXSID10237885 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10237885 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10237885 Vd NA 1.387 L/kg 1compartment NA NA Rat Human +DTXSID10237885 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10237885 TK.Half.Life NA 3.499 hours 1compartment NA NA Rat Human +DTXSID10237885 Css NA 0.05378 mg/L 3compartmentss NA 50% Rat Human +DTXSID10237885 Css NA 0.305 mg/L 3compartmentss NA 95% Rat Human +DTXSID10237885 Css NA 0.04004 mg/L PBTK NA 50% Rat Human +DTXSID10237885 Css NA 0.1919 mg/L PBTK NA 95% Rat Human DTXSID1023815 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1023815 Fup NA 0.5245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023815 Vd NA 0.8598 L/kg 1compartment NA NA Human Human +DTXSID1023815 Vd NA 0.9118 L/kg 1compartment NA NA Human Human DTXSID1023815 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1023815 TK.Half.Life NA 10.61 hours 1compartment NA NA Human Human -DTXSID1023815 Css NA 1.26 mg/L 3compartmentss NA 50% Human Human -DTXSID1023815 Css NA 7.489 mg/L 3compartmentss NA 95% Human Human -DTXSID1023815 Css NA 1.09 mg/L PBTK NA 50% Human Human -DTXSID1023815 Css NA 4.97 mg/L PBTK NA 95% Human Human +DTXSID1023815 TK.Half.Life NA 11.25 hours 1compartment NA NA Human Human +DTXSID1023815 Css NA 1.015 mg/L 3compartmentss NA 50% Human Human +DTXSID1023815 Css NA 6.376 mg/L 3compartmentss NA 95% Human Human +DTXSID1023815 Css NA 0.9116 mg/L PBTK NA 50% Human Human +DTXSID1023815 Css NA 4.209 mg/L PBTK NA 95% Human Human DTXSID1023815 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1023815 Fup NA 0.5245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023815 Vd NA 0.8659 L/kg 1compartment NA NA Rat Human +DTXSID1023815 Vd 0.37 0.9165 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID1023815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023815 TK.Half.Life NA 3.64 hours 1compartment NA NA Rat Human -DTXSID1023815 Css NA 0.3286 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023815 Css NA 1.803 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023815 Css NA 0.2772 mg/L PBTK NA 50% Rat Human -DTXSID1023815 Css NA 1.11 mg/L PBTK NA 95% Rat Human -DTXSID1023819 Clint NA 2.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1023815 TK.Half.Life 0.2 3.853 hours 1compartment National Toxicology Program NA Rat Human +DTXSID1023815 Css 0.032 0.01902 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID1023815 Css 0.032 0.1618 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID1023815 Css 0.032 0.01646 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID1023815 Css 0.032 0.1088 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID1023817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023817 Fup 0.0563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023817 Vd NA 2.265 L/kg 1compartment NA NA Human Human +DTXSID1023817 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1023817 TK.Half.Life NA 5.441 hours 1compartment NA NA Human Human +DTXSID1023817 Css NA 0.2348 mg/L 3compartmentss NA 50% Human Human +DTXSID1023817 Css NA 2.065 mg/L 3compartmentss NA 95% Human Human +DTXSID1023817 Css NA 0.1824 mg/L PBTK NA 50% Human Human +DTXSID1023817 Css NA 1.41 mg/L PBTK NA 95% Human Human +DTXSID1023817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023817 Fup 0.0563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023817 Vd NA 2.128 L/kg 1compartment NA NA Rat Human +DTXSID1023817 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1023817 TK.Half.Life NA 2.892 hours 1compartment NA NA Rat Human +DTXSID1023817 Css NA 0.03028 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023817 Css NA 0.2226 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023817 Css NA 0.02342 mg/L PBTK NA 50% Rat Human +DTXSID1023817 Css NA 0.1481 mg/L PBTK NA 95% Rat Human +DTXSID1023819 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1023819 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1023819 Vd NA 0.806 L/kg 1compartment NA NA Human Human DTXSID1023819 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023819 TK.Half.Life NA 1.426 hours 1compartment NA NA Human Human -DTXSID1023819 Css NA 0.1904 mg/L 3compartmentss NA 50% Human Human -DTXSID1023819 Css NA 1.487 mg/L 3compartmentss NA 95% Human Human -DTXSID1023819 Css NA 0.1588 mg/L PBTK NA 50% Human Human -DTXSID1023819 Css NA 0.9903 mg/L PBTK NA 95% Human Human -DTXSID1023819 Clint NA 2.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1023819 TK.Half.Life NA 5.219 hours 1compartment NA NA Human Human +DTXSID1023819 Css NA 0.7958 mg/L 3compartmentss NA 50% Human Human +DTXSID1023819 Css NA 5.49 mg/L 3compartmentss NA 95% Human Human +DTXSID1023819 Css NA 0.676 mg/L PBTK NA 50% Human Human +DTXSID1023819 Css NA 3.634 mg/L PBTK NA 95% Human Human +DTXSID1023819 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1023819 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1023819 Vd NA 0.8377 L/kg 1compartment NA NA Rat Human DTXSID1023819 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023819 TK.Half.Life NA 0.7623 hours 1compartment NA NA Rat Human -DTXSID1023819 Css NA 0.07875 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023819 Css NA 0.5377 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023819 Css NA 0.06553 mg/L PBTK NA 50% Rat Human -DTXSID1023819 Css NA 0.327 mg/L PBTK NA 95% Rat Human +DTXSID1023819 TK.Half.Life NA 1.847 hours 1compartment NA NA Rat Human +DTXSID1023819 Css NA 0.04639 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023819 Css NA 0.2937 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023819 Css NA 0.04005 mg/L PBTK NA 50% Rat Human +DTXSID1023819 Css NA 0.1837 mg/L PBTK NA 95% Rat Human DTXSID1023869 Clint 31.51 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1023869 Fup 0.003952 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1023869 Vd NA 0.4108 L/kg 1compartment NA NA Human Human DTXSID1023869 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1023869 TK.Half.Life NA 10.66 hours 1compartment NA NA Human Human -DTXSID1023869 Css NA 4.692 mg/L 3compartmentss NA 50% Human Human -DTXSID1023869 Css NA 39.67 mg/L 3compartmentss NA 95% Human Human -DTXSID1023869 Css NA 3.025 mg/L PBTK NA 50% Human Human -DTXSID1023869 Css NA 24.32 mg/L PBTK NA 95% Human Human +DTXSID1023869 Css NA 4.518 mg/L 3compartmentss NA 50% Human Human +DTXSID1023869 Css NA 38.25 mg/L 3compartmentss NA 95% Human Human +DTXSID1023869 Css NA 2.908 mg/L PBTK NA 50% Human Human +DTXSID1023869 Css NA 24.62 mg/L PBTK NA 95% Human Human DTXSID1023869 Clint 42.06 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID1023869 Fup 0.1823 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID1023869 Vd NA 1.748 L/kg 1compartment NA NA Rat Rat DTXSID1023869 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID1023869 TK.Half.Life NA 1.249 hours 1compartment NA NA Rat Rat -DTXSID1023869 Css NA 0.0739 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1023869 Css NA 0.3757 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1023869 Css NA 0.0426 mg/L PBTK NA 50% Rat Rat -DTXSID1023869 Css NA 0.2165 mg/L PBTK NA 95% Rat Rat +DTXSID1023869 Css NA 0.01482 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1023869 Css NA 0.07606 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1023869 Css NA 0.00988 mg/L PBTK NA 50% Rat Rat +DTXSID1023869 Css NA 0.0507 mg/L PBTK NA 95% Rat Rat DTXSID1023990 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1023990 Fup 0.3155 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1023990 Vd NA 1.666 L/kg 1compartment NA NA Human Human DTXSID1023990 Days.Css NA 7 Days PBTK NA NA Human Human DTXSID1023990 TK.Half.Life NA 47.22 hours 1compartment NA NA Human Human -DTXSID1023990 Css NA 3.041 mg/L 3compartmentss NA 50% Human Human -DTXSID1023990 Css NA 11.2 mg/L 3compartmentss NA 95% Human Human -DTXSID1023990 Css NA 2.343 mg/L PBTK NA 50% Human Human -DTXSID1023990 Css NA 7.466 mg/L PBTK NA 95% Human Human +DTXSID1023990 Css NA 2.97 mg/L 3compartmentss NA 50% Human Human +DTXSID1023990 Css NA 10.87 mg/L 3compartmentss NA 95% Human Human +DTXSID1023990 Css NA 2.282 mg/L PBTK NA 50% Human Human +DTXSID1023990 Css NA 7.207 mg/L PBTK NA 95% Human Human DTXSID1023990 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1023990 Fup 0.3155 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1023990 Vd NA 1.336 L/kg 1compartment NA NA Rat Human DTXSID1023990 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID1023990 TK.Half.Life NA 10.19 hours 1compartment NA NA Rat Human -DTXSID1023990 Css NA 0.8259 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023990 Css NA 2.537 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023990 Css NA 0.6116 mg/L PBTK NA 50% Rat Human -DTXSID1023990 Css NA 1.568 mg/L PBTK NA 95% Rat Human -DTXSID1023996 Clint NA 1.413 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023996 Fup NA 0.6994 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023996 Vd NA 2.433 L/kg 1compartment NA NA Human Human -DTXSID1023996 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1023996 TK.Half.Life NA 7.107 hours 1compartment NA NA Human Human -DTXSID1023996 Css NA 0.2356 mg/L 3compartmentss NA 50% Human Human -DTXSID1023996 Css NA 2.085 mg/L 3compartmentss NA 95% Human Human -DTXSID1023996 Css NA 0.2689 mg/L PBTK NA 50% Human Human -DTXSID1023996 Css NA 1.52 mg/L PBTK NA 95% Human Human -DTXSID1023996 Clint NA 1.413 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023996 Fup NA 0.6994 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1023996 Vd NA 2.413 L/kg 1compartment NA NA Rat Human +DTXSID1023990 Css NA 0.1869 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023990 Css NA 0.5826 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023990 Css NA 0.1434 mg/L PBTK NA 50% Rat Human +DTXSID1023990 Css NA 0.3725 mg/L PBTK NA 95% Rat Human +DTXSID1023996 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023996 Fup 0.614 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023996 Vd NA 2.21 L/kg 1compartment NA NA Human Human +DTXSID1023996 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1023996 TK.Half.Life NA 23.29 hours 1compartment NA NA Human Human +DTXSID1023996 Css NA 0.758 mg/L 3compartmentss NA 50% Human Human +DTXSID1023996 Css NA 6.334 mg/L 3compartmentss NA 95% Human Human +DTXSID1023996 Css NA 0.8282 mg/L PBTK NA 50% Human Human +DTXSID1023996 Css NA 4.463 mg/L PBTK NA 95% Human Human +DTXSID1023996 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023996 Fup 0.614 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1023996 Vd NA 2.187 L/kg 1compartment NA NA Rat Human DTXSID1023996 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1023996 TK.Half.Life NA 3.631 hours 1compartment NA NA Rat Human -DTXSID1023996 Css NA 0.09191 mg/L 3compartmentss NA 50% Rat Human -DTXSID1023996 Css NA 0.8077 mg/L 3compartmentss NA 95% Rat Human -DTXSID1023996 Css NA 0.1052 mg/L PBTK NA 50% Rat Human -DTXSID1023996 Css NA 0.5429 mg/L PBTK NA 95% Rat Human -DTXSID1023998 Clint NA 53.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023998 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1023998 Vd NA 8.056 L/kg 1compartment NA NA Human Human -DTXSID1023998 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID1023998 TK.Half.Life NA 100.7 hours 1compartment NA NA Human Human -DTXSID1023998 Css NA 0.949 mg/L 3compartmentss NA 50% Human Human -DTXSID1023998 Css NA 5.689 mg/L 3compartmentss NA 95% Human Human -DTXSID1023998 Css NA 0.9798 mg/L PBTK NA 50% Human Human -DTXSID1023998 Css NA 5.643 mg/L PBTK NA 95% Human Human +DTXSID1023996 TK.Half.Life NA 7.854 hours 1compartment NA NA Rat Human +DTXSID1023996 Css NA 0.01411 mg/L 3compartmentss NA 50% Rat Human +DTXSID1023996 Css NA 0.141 mg/L 3compartmentss NA 95% Rat Human +DTXSID1023996 Css NA 0.01489 mg/L PBTK NA 50% Rat Human +DTXSID1023996 Css NA 0.1036 mg/L PBTK NA 95% Rat Human +DTXSID1023998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023998 Fup 0.00389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1023998 Vd NA 7.937 L/kg 1compartment NA NA Human Human +DTXSID1023998 Days.Css NA 48 Days PBTK NA NA Human Human +DTXSID1023998 TK.Half.Life NA 243.9 hours 1compartment NA NA Human Human +DTXSID1023998 Css NA 2.411 mg/L 3compartmentss NA 50% Human Human +DTXSID1023998 Css NA 14.26 mg/L 3compartmentss NA 95% Human Human +DTXSID1023998 Css NA 2.45 mg/L PBTK NA 50% Human Human +DTXSID1023998 Css NA 14.19 mg/L PBTK NA 95% Human Human DTXSID1023998 Clint 4.5 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1023998 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID1023998 Css NA 6.286 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1023998 Css NA 26.47 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1024045 Clint NA 0.02815 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024045 Fup NA 0.7043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024045 Vd NA 1.2 L/kg 1compartment NA NA Human Human +DTXSID1023998 Css NA 2.211 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1023998 Css NA 10.37 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1024045 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024045 Fup 0.674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024045 Vd NA 1.169 L/kg 1compartment NA NA Human Human DTXSID1024045 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1024045 TK.Half.Life NA 11.27 hours 1compartment NA NA Human Human -DTXSID1024045 Css NA 0.9769 mg/L 3compartmentss NA 50% Human Human -DTXSID1024045 Css NA 6.49 mg/L 3compartmentss NA 95% Human Human -DTXSID1024045 Css NA 0.8712 mg/L PBTK NA 50% Human Human -DTXSID1024045 Css NA 4.295 mg/L PBTK NA 95% Human Human -DTXSID1024045 Clint NA 0.02815 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024045 Fup NA 0.7043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024045 Vd NA 1.103 L/kg 1compartment NA NA Rat Human +DTXSID1024045 TK.Half.Life NA 11.98 hours 1compartment NA NA Human Human +DTXSID1024045 Css NA 0.9148 mg/L 3compartmentss NA 50% Human Human +DTXSID1024045 Css NA 6.224 mg/L 3compartmentss NA 95% Human Human +DTXSID1024045 Css NA 0.8006 mg/L PBTK NA 50% Human Human +DTXSID1024045 Css NA 4.087 mg/L PBTK NA 95% Human Human +DTXSID1024045 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024045 Fup 0.674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024045 Vd NA 1.074 L/kg 1compartment NA NA Rat Human DTXSID1024045 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024045 TK.Half.Life NA 3.431 hours 1compartment NA NA Rat Human -DTXSID1024045 Css NA 0.2643 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024045 Css NA 1.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024045 Css NA 0.2261 mg/L PBTK NA 50% Rat Human -DTXSID1024045 Css NA 1.072 mg/L PBTK NA 95% Rat Human +DTXSID1024045 TK.Half.Life NA 3.571 hours 1compartment NA NA Rat Human +DTXSID1024045 Css NA 0.01745 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024045 Css NA 0.1485 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024045 Css NA 0.01466 mg/L PBTK NA 50% Rat Human +DTXSID1024045 Css NA 0.09818 mg/L PBTK NA 95% Rat Human DTXSID1024049 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1024049 Fup 0.0308 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1024049 Vd NA 2.349 L/kg 1compartment NA NA Human Human -DTXSID1024049 Days.Css NA 348 Days PBTK NA NA Human Human +DTXSID1024049 Days.Css NA 345 Days PBTK NA NA Human Human DTXSID1024049 TK.Half.Life NA 1335 hours 1compartment NA NA Human Human -DTXSID1024049 Css NA 68.19 mg/L 3compartmentss NA 50% Human Human -DTXSID1024049 Css NA 211.4 mg/L 3compartmentss NA 95% Human Human -DTXSID1024049 Css NA 45.86 mg/L PBTK NA 50% Human Human -DTXSID1024049 Css NA 132.4 mg/L PBTK NA 95% Human Human +DTXSID1024049 Css NA 65.22 mg/L 3compartmentss NA 50% Human Human +DTXSID1024049 Css NA 207.1 mg/L 3compartmentss NA 95% Human Human +DTXSID1024049 Css NA 43.88 mg/L PBTK NA 50% Human Human +DTXSID1024049 Css NA 129.4 mg/L PBTK NA 95% Human Human DTXSID1024049 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1024049 Fup 0.0308 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1024049 Vd NA 1.754 L/kg 1compartment NA NA Rat Human DTXSID1024049 Days.Css NA 85 Days PBTK NA NA Rat Human DTXSID1024049 TK.Half.Life NA 176.6 hours 1compartment NA NA Rat Human -DTXSID1024049 Css NA 18.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024049 Css NA 48.56 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024049 Css NA 11.8 mg/L PBTK NA 50% Rat Human -DTXSID1024049 Css NA 28.21 mg/L PBTK NA 95% Rat Human +DTXSID1024049 Css NA 4.155 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024049 Css NA 10.89 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024049 Css NA 2.748 mg/L PBTK NA 50% Rat Human +DTXSID1024049 Css NA 6.556 mg/L PBTK NA 95% Rat Human DTXSID1024091 Clint 80.36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID1024091 Fup NA 0.2367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024091 Vd NA 2.679 L/kg 1compartment NA NA Human Human +DTXSID1024091 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024091 Vd NA 2.392 L/kg 1compartment NA NA Human Human DTXSID1024091 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024091 TK.Half.Life NA 3.56 hours 1compartment NA NA Human Human -DTXSID1024091 Css NA 0.06826 mg/L 3compartmentss NA 50% Human Human -DTXSID1024091 Css NA 0.4549 mg/L 3compartmentss NA 95% Human Human -DTXSID1024091 Css NA 0.05 mg/L PBTK NA 50% Human Human -DTXSID1024091 Css NA 0.312 mg/L PBTK NA 95% Human Human +DTXSID1024091 TK.Half.Life NA 3.506 hours 1compartment NA NA Human Human +DTXSID1024091 Css NA 0.08764 mg/L 3compartmentss NA 50% Human Human +DTXSID1024091 Css NA 0.6633 mg/L 3compartmentss NA 95% Human Human +DTXSID1024091 Css NA 0.06147 mg/L PBTK NA 50% Human Human +DTXSID1024091 Css NA 0.4368 mg/L PBTK NA 95% Human Human DTXSID1024091 Clint 80.36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID1024091 Fup NA 0.2367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024091 Vd NA 2.039 L/kg 1compartment NA NA Rat Human +DTXSID1024091 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024091 Vd NA 1.814 L/kg 1compartment NA NA Rat Human DTXSID1024091 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024091 TK.Half.Life NA 1.018 hours 1compartment NA NA Rat Human -DTXSID1024091 Css NA 0.03819 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024091 Css NA 0.2022 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024091 Css NA 0.02686 mg/L PBTK NA 50% Rat Human -DTXSID1024091 Css NA 0.14 mg/L PBTK NA 95% Rat Human +DTXSID1024091 TK.Half.Life NA 1.067 hours 1compartment NA NA Rat Human +DTXSID1024091 Css NA 0.01143 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024091 Css NA 0.0703 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024091 Css NA 0.007892 mg/L PBTK NA 50% Rat Human +DTXSID1024091 Css NA 0.0458 mg/L PBTK NA 95% Rat Human DTXSID1024097 Clint 4.299 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID1024097 Fup 0.8332 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID1024097 Vd NA 1.132 L/kg 1compartment NA NA Human Human DTXSID1024097 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1024097 TK.Half.Life NA 1.598 hours 1compartment NA NA Human Human -DTXSID1024097 Css NA 0.1204 mg/L 3compartmentss NA 50% Human Human -DTXSID1024097 Css NA 0.9198 mg/L 3compartmentss NA 95% Human Human -DTXSID1024097 Css NA 0.1053 mg/L PBTK NA 50% Human Human -DTXSID1024097 Css NA 0.6578 mg/L PBTK NA 95% Human Human +DTXSID1024097 Css NA 0.09653 mg/L 3compartmentss NA 50% Human Human +DTXSID1024097 Css NA 0.835 mg/L 3compartmentss NA 95% Human Human +DTXSID1024097 Css NA 0.08506 mg/L PBTK NA 50% Human Human +DTXSID1024097 Css NA 0.5924 mg/L PBTK NA 95% Human Human DTXSID1024097 Clint 6.691 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID1024097 Fup 0.5544 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID1024097 Vd NA 0.8419 L/kg 1compartment NA NA Rat Rat DTXSID1024097 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID1024097 TK.Half.Life NA 0.6918 hours 1compartment NA NA Rat Rat -DTXSID1024097 Css NA 0.05692 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1024097 Css NA 0.4171 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1024097 Css NA 0.04485 mg/L PBTK NA 50% Rat Rat -DTXSID1024097 Css NA 0.2564 mg/L PBTK NA 95% Rat Rat -DTXSID1024124 Clint NA 8.096 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024124 Fup NA 0.0878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024124 Vd NA 0.2769 L/kg 1compartment NA NA Human Human +DTXSID1024097 Css NA 0.003188 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1024097 Css NA 0.03457 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1024097 Css NA 0.002552 mg/L PBTK NA 50% Rat Rat +DTXSID1024097 Css NA 0.02253 mg/L PBTK NA 95% Rat Rat +DTXSID1024124 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024124 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024124 Vd NA 0.546 L/kg 1compartment NA NA Human Human DTXSID1024124 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024124 TK.Half.Life NA 1.629 hours 1compartment NA NA Human Human -DTXSID1024124 Css NA 0.8913 mg/L 3compartmentss NA 50% Human Human -DTXSID1024124 Css NA 6.513 mg/L 3compartmentss NA 95% Human Human -DTXSID1024124 Css NA 0.5466 mg/L PBTK NA 50% Human Human -DTXSID1024124 Css NA 3.905 mg/L PBTK NA 95% Human Human -DTXSID1024124 Clint NA 8.096 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024124 Fup NA 0.0878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024124 Vd NA 0.2745 L/kg 1compartment NA NA Rat Human +DTXSID1024124 TK.Half.Life NA 3.37 hours 1compartment NA NA Human Human +DTXSID1024124 Css NA 0.7636 mg/L 3compartmentss NA 50% Human Human +DTXSID1024124 Css NA 5.441 mg/L 3compartmentss NA 95% Human Human +DTXSID1024124 Css NA 0.4833 mg/L PBTK NA 50% Human Human +DTXSID1024124 Css NA 3.287 mg/L PBTK NA 95% Human Human +DTXSID1024124 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024124 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024124 Vd NA 0.4696 L/kg 1compartment NA NA Rat Human DTXSID1024124 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024124 TK.Half.Life NA 0.9972 hours 1compartment NA NA Rat Human -DTXSID1024124 Css NA 0.4774 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024124 Css NA 2.527 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024124 Css NA 0.2754 mg/L PBTK NA 50% Rat Human -DTXSID1024124 Css NA 1.396 mg/L PBTK NA 95% Rat Human +DTXSID1024124 TK.Half.Life NA 1.737 hours 1compartment NA NA Rat Human +DTXSID1024124 Css NA 0.03437 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024124 Css NA 0.2719 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024124 Css NA 0.02086 mg/L PBTK NA 50% Rat Human +DTXSID1024124 Css NA 0.1581 mg/L PBTK NA 95% Rat Human DTXSID1024126 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1024126 Fup 0.01068 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1024126 Vd NA 2.893 L/kg 1compartment NA NA Human Human DTXSID1024126 Days.Css NA 3276 Days PBTK NA NA Human Human DTXSID1024126 TK.Half.Life NA 14800 hours 1compartment NA NA Human Human -DTXSID1024126 Css NA 641.2 mg/L 3compartmentss NA 50% Human Human -DTXSID1024126 Css NA 1940 mg/L 3compartmentss NA 95% Human Human -DTXSID1024126 Css NA 435.8 mg/L PBTK NA 50% Human Human -DTXSID1024126 Css NA 1231 mg/L PBTK NA 95% Human Human +DTXSID1024126 Css NA 622 mg/L 3compartmentss NA 50% Human Human +DTXSID1024126 Css NA 1937 mg/L 3compartmentss NA 95% Human Human +DTXSID1024126 Css NA 423.4 mg/L PBTK NA 50% Human Human +DTXSID1024126 Css NA 1212 mg/L PBTK NA 95% Human Human DTXSID1024126 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1024126 Fup 0.01068 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1024126 Vd NA 2.163 L/kg 1compartment NA NA Rat Human -DTXSID1024126 Days.Css NA 1041 Days PBTK NA NA Rat Human +DTXSID1024126 Days.Css NA 1035 Days PBTK NA NA Rat Human DTXSID1024126 TK.Half.Life NA 1239 hours 1compartment NA NA Rat Human -DTXSID1024126 Css NA 174.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024126 Css NA 440.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024126 Css NA 113.1 mg/L PBTK NA 50% Rat Human -DTXSID1024126 Css NA 258.5 mg/L PBTK NA 95% Rat Human +DTXSID1024126 Css NA 39.26 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024126 Css NA 95.73 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024126 Css NA 26.32 mg/L PBTK NA 50% Rat Human +DTXSID1024126 Css NA 58.27 mg/L PBTK NA 95% Rat Human +DTXSID1024128 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1024128 Fup NA 0.0266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1024128 Vd NA 3.483 L/kg 1compartment NA NA Human Human +DTXSID1024128 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID1024128 TK.Half.Life NA 165300 hours 1compartment NA NA Human Human +DTXSID1024128 Css NA 4340 mg/L 3compartmentss NA 50% Human Human +DTXSID1024128 Css NA 9994 mg/L 3compartmentss NA 95% Human Human +DTXSID1024128 Css NA 3119 mg/L PBTK NA 50% Human Human +DTXSID1024128 Css NA 6843 mg/L PBTK NA 95% Human Human +DTXSID1024128 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1024128 Fup NA 0.0266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1024128 Vd NA 2.62 L/kg 1compartment NA NA Rat Human +DTXSID1024128 Days.Css NA 8526 Days PBTK NA NA Rat Human +DTXSID1024128 TK.Half.Life NA 10270 hours 1compartment NA NA Rat Human +DTXSID1024128 Css NA 72.5 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024128 Css NA 327.9 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024128 Css NA 50.24 mg/L PBTK NA 50% Rat Human +DTXSID1024128 Css NA 225.6 mg/L PBTK NA 95% Rat Human DTXSID1024174 Clint 125.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1024174 Fup 0.06651 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1024174 Vd NA 3.129 L/kg 1compartment NA NA Human Human DTXSID1024174 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1024174 TK.Half.Life NA 17.21 hours 1compartment NA NA Human Human -DTXSID1024174 Css NA 0.577 mg/L 3compartmentss NA 50% Human Human -DTXSID1024174 Css NA 3.638 mg/L 3compartmentss NA 95% Human Human -DTXSID1024174 Css NA 0.4002 mg/L PBTK NA 50% Human Human -DTXSID1024174 Css NA 2.453 mg/L PBTK NA 95% Human Human +DTXSID1024174 Css NA 0.5616 mg/L 3compartmentss NA 50% Human Human +DTXSID1024174 Css NA 3.48 mg/L 3compartmentss NA 95% Human Human +DTXSID1024174 Css NA 0.3897 mg/L PBTK NA 50% Human Human +DTXSID1024174 Css NA 2.358 mg/L PBTK NA 95% Human Human DTXSID1024174 Clint 125.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1024174 Fup 0.06651 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1024174 Vd NA 2.346 L/kg 1compartment NA NA Rat Human DTXSID1024174 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1024174 TK.Half.Life NA 2.704 hours 1compartment NA NA Rat Human -DTXSID1024174 Css NA 0.3264 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024174 Css NA 1.623 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024174 Css NA 0.2177 mg/L PBTK NA 50% Rat Human -DTXSID1024174 Css NA 1.056 mg/L PBTK NA 95% Rat Human -DTXSID1024176 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024176 Fup NA 0.8532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024176 Vd NA 1.075 L/kg 1compartment NA NA Human Human -DTXSID1024176 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024176 TK.Half.Life NA 8.395 hours 1compartment NA NA Human Human -DTXSID1024176 Css NA 0.9054 mg/L 3compartmentss NA 50% Human Human -DTXSID1024176 Css NA 5.691 mg/L 3compartmentss NA 95% Human Human -DTXSID1024176 Css NA 0.7999 mg/L PBTK NA 50% Human Human -DTXSID1024176 Css NA 3.791 mg/L PBTK NA 95% Human Human -DTXSID1024176 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024176 Fup NA 0.8532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024176 Vd NA 1.039 L/kg 1compartment NA NA Rat Human -DTXSID1024176 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024176 TK.Half.Life NA 2.704 hours 1compartment NA NA Rat Human -DTXSID1024176 Css NA 0.2295 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024176 Css NA 1.373 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024176 Css NA 0.1983 mg/L PBTK NA 50% Rat Human -DTXSID1024176 Css NA 0.846 mg/L PBTK NA 95% Rat Human -DTXSID1024209 Clint NA 0.2211 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024209 Fup NA 0.1328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024209 Vd NA 0.547 L/kg 1compartment NA NA Human Human -DTXSID1024209 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1024209 TK.Half.Life NA 19.82 hours 1compartment NA NA Human Human -DTXSID1024209 Css NA 5.172 mg/L 3compartmentss NA 50% Human Human -DTXSID1024209 Css NA 24.65 mg/L 3compartmentss NA 95% Human Human -DTXSID1024209 Css NA 3.319 mg/L PBTK NA 50% Human Human -DTXSID1024209 Css NA 14.7 mg/L PBTK NA 95% Human Human -DTXSID1024209 Clint NA 0.2211 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024209 Fup NA 0.1328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024209 Vd NA 0.4822 L/kg 1compartment NA NA Rat Human -DTXSID1024209 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024209 TK.Half.Life NA 6.809 hours 1compartment NA NA Rat Human -DTXSID1024209 Css NA 1.729 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024209 Css NA 6.987 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024209 Css NA 1.044 mg/L PBTK NA 50% Rat Human -DTXSID1024209 Css NA 3.9 mg/L PBTK NA 95% Rat Human -DTXSID1024255 Clint NA 23.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024255 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024255 Vd NA 1.816 L/kg 1compartment NA NA Human Human -DTXSID1024255 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024255 TK.Half.Life NA 12.48 hours 1compartment NA NA Human Human -DTXSID1024255 Css NA 1.008 mg/L 3compartmentss NA 50% Human Human -DTXSID1024255 Css NA 8.268 mg/L 3compartmentss NA 95% Human Human -DTXSID1024255 Css NA 0.6461 mg/L PBTK NA 50% Human Human -DTXSID1024255 Css NA 5.014 mg/L PBTK NA 95% Human Human -DTXSID1024255 Clint NA 23.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024255 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024255 Vd NA 1.353 L/kg 1compartment NA NA Rat Human +DTXSID1024174 Css NA 0.07303 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024174 Css NA 0.4005 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024174 Css NA 0.05028 mg/L PBTK NA 50% Rat Human +DTXSID1024174 Css NA 0.2691 mg/L PBTK NA 95% Rat Human +DTXSID1024255 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024255 Fup 0.0198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024255 Vd NA 1.53 L/kg 1compartment NA NA Human Human +DTXSID1024255 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1024255 TK.Half.Life NA 14.27 hours 1compartment NA NA Human Human +DTXSID1024255 Css NA 1.44 mg/L 3compartmentss NA 50% Human Human +DTXSID1024255 Css NA 12.32 mg/L 3compartmentss NA 95% Human Human +DTXSID1024255 Css NA 0.9028 mg/L PBTK NA 50% Human Human +DTXSID1024255 Css NA 7.399 mg/L PBTK NA 95% Human Human +DTXSID1024255 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024255 Fup 0.0198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024255 Vd NA 1.134 L/kg 1compartment NA NA Rat Human DTXSID1024255 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024255 TK.Half.Life NA 4.327 hours 1compartment NA NA Rat Human -DTXSID1024255 Css NA 0.5716 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024255 Css NA 3.663 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024255 Css NA 0.3452 mg/L PBTK NA 50% Rat Human -DTXSID1024255 Css NA 2.113 mg/L PBTK NA 95% Rat Human +DTXSID1024255 TK.Half.Life NA 5.436 hours 1compartment NA NA Rat Human +DTXSID1024255 Css NA 0.1863 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024255 Css NA 1.421 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024255 Css NA 0.1134 mg/L PBTK NA 50% Rat Human +DTXSID1024255 Css NA 0.8304 mg/L PBTK NA 95% Rat Human DTXSID1024259 Clint 25.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1024259 Fup 0.00608 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1024259 Vd NA 2.048 L/kg 1compartment NA NA Human Human DTXSID1024259 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID1024259 TK.Half.Life NA 36.75 hours 1compartment NA NA Human Human -DTXSID1024259 Css NA 2.202 mg/L 3compartmentss NA 50% Human Human -DTXSID1024259 Css NA 14.71 mg/L 3compartmentss NA 95% Human Human -DTXSID1024259 Css NA 1.429 mg/L PBTK NA 50% Human Human -DTXSID1024259 Css NA 9.26 mg/L PBTK NA 95% Human Human +DTXSID1024259 Css NA 2.096 mg/L 3compartmentss NA 50% Human Human +DTXSID1024259 Css NA 15.12 mg/L 3compartmentss NA 95% Human Human +DTXSID1024259 Css NA 1.364 mg/L PBTK NA 50% Human Human +DTXSID1024259 Css NA 9.516 mg/L PBTK NA 95% Human Human DTXSID1024259 Clint 25.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1024259 Fup 0.00608 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1024259 Vd NA 1.516 L/kg 1compartment NA NA Rat Human DTXSID1024259 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID1024259 TK.Half.Life NA 11.52 hours 1compartment NA NA Rat Human -DTXSID1024259 Css NA 1.216 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024259 Css NA 6.853 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024259 Css NA 0.7485 mg/L PBTK NA 50% Rat Human -DTXSID1024259 Css NA 4.107 mg/L PBTK NA 95% Rat Human -DTXSID1024334 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024334 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024334 Vd NA 2.278 L/kg 1compartment NA NA Human Human -DTXSID1024334 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID1024334 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human -DTXSID1024334 Css NA 5.766 mg/L 3compartmentss NA 50% Human Human -DTXSID1024334 Css NA 18.35 mg/L 3compartmentss NA 95% Human Human -DTXSID1024334 Css NA 4.315 mg/L PBTK NA 50% Human Human -DTXSID1024334 Css NA 12.3 mg/L PBTK NA 95% Human Human -DTXSID1024334 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024334 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024334 Vd NA 1.758 L/kg 1compartment NA NA Rat Human -DTXSID1024334 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID1024334 TK.Half.Life NA 18.69 hours 1compartment NA NA Rat Human -DTXSID1024334 Css NA 1.568 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024334 Css NA 4.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024334 Css NA 1.13 mg/L PBTK NA 50% Rat Human -DTXSID1024334 Css NA 2.563 mg/L PBTK NA 95% Rat Human +DTXSID1024259 Css NA 0.2728 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024259 Css NA 1.632 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024259 Css NA 0.1742 mg/L PBTK NA 50% Rat Human +DTXSID1024259 Css NA 1.025 mg/L PBTK NA 95% Rat Human DTXSID1024338 Clint 2.469 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1024338 Fup 0.427 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1024338 Vd NA 1.049 L/kg 1compartment NA NA Human Human DTXSID1024338 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1024338 TK.Half.Life NA 3.749 hours 1compartment NA NA Human Human -DTXSID1024338 Css NA 0.3437 mg/L 3compartmentss NA 50% Human Human -DTXSID1024338 Css NA 2.053 mg/L 3compartmentss NA 95% Human Human -DTXSID1024338 Css NA 0.2704 mg/L PBTK NA 50% Human Human -DTXSID1024338 Css NA 1.39 mg/L PBTK NA 95% Human Human +DTXSID1024338 Css NA 0.3328 mg/L 3compartmentss NA 50% Human Human +DTXSID1024338 Css NA 1.922 mg/L 3compartmentss NA 95% Human Human +DTXSID1024338 Css NA 0.2621 mg/L PBTK NA 50% Human Human +DTXSID1024338 Css NA 1.307 mg/L PBTK NA 95% Human Human DTXSID1024338 Clint 2.469 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1024338 Fup 0.427 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1024338 Vd NA 0.9284 L/kg 1compartment NA NA Rat Human DTXSID1024338 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1024338 TK.Half.Life NA 1.726 hours 1compartment NA NA Rat Human -DTXSID1024338 Css NA 0.1555 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024338 Css NA 0.7073 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024338 Css NA 0.1193 mg/L PBTK NA 50% Rat Human -DTXSID1024338 Css NA 0.4372 mg/L PBTK NA 95% Rat Human -DTXSID1024413 Clint NA 0.6756 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024413 Fup NA 0.5246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024413 Vd NA 0.8696 L/kg 1compartment NA NA Human Human +DTXSID1024338 Css NA 0.0354 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024338 Css NA 0.1616 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024338 Css NA 0.02795 mg/L PBTK NA 50% Rat Human +DTXSID1024338 Css NA 0.104 mg/L PBTK NA 95% Rat Human +DTXSID1024413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024413 Fup 0.353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024413 Vd NA 0.6917 L/kg 1compartment NA NA Human Human DTXSID1024413 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024413 TK.Half.Life NA 5.328 hours 1compartment NA NA Human Human -DTXSID1024413 Css NA 0.643 mg/L 3compartmentss NA 50% Human Human -DTXSID1024413 Css NA 3.786 mg/L 3compartmentss NA 95% Human Human -DTXSID1024413 Css NA 0.5171 mg/L PBTK NA 50% Human Human -DTXSID1024413 Css NA 2.48 mg/L PBTK NA 95% Human Human -DTXSID1024413 Clint NA 0.6756 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024413 Fup NA 0.5246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024413 Vd NA 0.8234 L/kg 1compartment NA NA Rat Human +DTXSID1024413 TK.Half.Life NA 0.8276 hours 1compartment NA NA Human Human +DTXSID1024413 Css NA 0.0564 mg/L 3compartmentss NA 50% Human Human +DTXSID1024413 Css NA 0.4374 mg/L 3compartmentss NA 95% Human Human +DTXSID1024413 Css NA 0.04142 mg/L PBTK NA 50% Human Human +DTXSID1024413 Css NA 0.2955 mg/L PBTK NA 95% Human Human +DTXSID1024413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024413 Fup 0.353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024413 Vd NA 0.6526 L/kg 1compartment NA NA Rat Human DTXSID1024413 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024413 TK.Half.Life NA 2.278 hours 1compartment NA NA Rat Human -DTXSID1024413 Css NA 0.2354 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024413 Css NA 1.262 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024413 Css NA 0.1832 mg/L PBTK NA 50% Rat Human -DTXSID1024413 Css NA 0.7608 mg/L PBTK NA 95% Rat Human -DTXSID1024463 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024463 Fup NA 0.4669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024463 Vd NA 0.4085 L/kg 1compartment NA NA Human Human +DTXSID1024413 TK.Half.Life NA 0.4065 hours 1compartment NA NA Rat Human +DTXSID1024413 Css NA 0.007054 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024413 Css NA 0.04044 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024413 Css NA 0.00516 mg/L PBTK NA 50% Rat Human +DTXSID1024413 Css NA 0.02692 mg/L PBTK NA 95% Rat Human +DTXSID1024463 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024463 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024463 Vd NA 0.4961 L/kg 1compartment NA NA Human Human DTXSID1024463 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024463 TK.Half.Life NA 5.663 hours 1compartment NA NA Human Human -DTXSID1024463 Css NA 1.632 mg/L 3compartmentss NA 50% Human Human -DTXSID1024463 Css NA 7.549 mg/L 3compartmentss NA 95% Human Human -DTXSID1024463 Css NA 1.171 mg/L PBTK NA 50% Human Human -DTXSID1024463 Css NA 4.695 mg/L PBTK NA 95% Human Human -DTXSID1024463 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024463 Fup NA 0.4669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024463 Vd NA 0.4343 L/kg 1compartment NA NA Rat Human +DTXSID1024463 TK.Half.Life NA 9.197 hours 1compartment NA NA Human Human +DTXSID1024463 Css NA 2.057 mg/L 3compartmentss NA 50% Human Human +DTXSID1024463 Css NA 8.195 mg/L 3compartmentss NA 95% Human Human +DTXSID1024463 Css NA 1.492 mg/L PBTK NA 50% Human Human +DTXSID1024463 Css NA 5.198 mg/L PBTK NA 95% Human Human +DTXSID1024463 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024463 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024463 Vd NA 0.5014 L/kg 1compartment NA NA Rat Human DTXSID1024463 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024463 TK.Half.Life NA 2.051 hours 1compartment NA NA Rat Human -DTXSID1024463 Css NA 0.4482 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024463 Css NA 1.756 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024463 Css NA 0.3048 mg/L PBTK NA 50% Rat Human -DTXSID1024463 Css NA 1.022 mg/L PBTK NA 95% Rat Human -DTXSID1024465 Clint NA 0.9083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024465 Fup NA 0.674 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024465 Vd NA 2.083 L/kg 1compartment NA NA Human Human +DTXSID1024463 TK.Half.Life NA 3.168 hours 1compartment NA NA Rat Human +DTXSID1024463 Css NA 0.1298 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024463 Css NA 0.4662 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024463 Css NA 0.09326 mg/L PBTK NA 50% Rat Human +DTXSID1024463 Css NA 0.2843 mg/L PBTK NA 95% Rat Human +DTXSID1024465 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024465 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024465 Vd NA 1.595 L/kg 1compartment NA NA Human Human DTXSID1024465 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024465 TK.Half.Life NA 8.493 hours 1compartment NA NA Human Human -DTXSID1024465 Css NA 0.3702 mg/L 3compartmentss NA 50% Human Human -DTXSID1024465 Css NA 2.927 mg/L 3compartmentss NA 95% Human Human -DTXSID1024465 Css NA 0.3738 mg/L PBTK NA 50% Human Human -DTXSID1024465 Css NA 2.006 mg/L PBTK NA 95% Human Human -DTXSID1024465 Clint NA 0.9083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024465 Fup NA 0.674 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024465 Vd NA 2.09 L/kg 1compartment NA NA Rat Human +DTXSID1024465 TK.Half.Life NA 1.525 hours 1compartment NA NA Human Human +DTXSID1024465 Css NA 0.03693 mg/L 3compartmentss NA 50% Human Human +DTXSID1024465 Css NA 0.351 mg/L 3compartmentss NA 95% Human Human +DTXSID1024465 Css NA 0.0327 mg/L PBTK NA 50% Human Human +DTXSID1024465 Css NA 0.2564 mg/L PBTK NA 95% Human Human +DTXSID1024465 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024465 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024465 Vd NA 1.592 L/kg 1compartment NA NA Rat Human DTXSID1024465 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024465 TK.Half.Life NA 4.042 hours 1compartment NA NA Rat Human -DTXSID1024465 Css NA 0.1344 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024465 Css NA 1.056 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024465 Css NA 0.1347 mg/L PBTK NA 50% Rat Human -DTXSID1024465 Css NA 0.6747 mg/L PBTK NA 95% Rat Human -DTXSID1024467 Clint NA 2.977 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024467 Fup NA 0.3392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024467 Vd NA 1.357 L/kg 1compartment NA NA Human Human +DTXSID1024465 TK.Half.Life NA 0.7894 hours 1compartment NA NA Rat Human +DTXSID1024465 Css NA 0.004488 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024465 Css NA 0.03221 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024465 Css NA 0.004054 mg/L PBTK NA 50% Rat Human +DTXSID1024465 Css NA 0.02378 mg/L PBTK NA 95% Rat Human +DTXSID1024467 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024467 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024467 Vd NA 1.033 L/kg 1compartment NA NA Human Human DTXSID1024467 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024467 TK.Half.Life NA 5.645 hours 1compartment NA NA Human Human -DTXSID1024467 Css NA 0.4098 mg/L 3compartmentss NA 50% Human Human -DTXSID1024467 Css NA 2.186 mg/L 3compartmentss NA 95% Human Human -DTXSID1024467 Css NA 0.3174 mg/L PBTK NA 50% Human Human -DTXSID1024467 Css NA 1.464 mg/L PBTK NA 95% Human Human -DTXSID1024467 Clint NA 2.977 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024467 Fup NA 0.3392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024467 Vd NA 1.124 L/kg 1compartment NA NA Rat Human +DTXSID1024467 TK.Half.Life NA 1.712 hours 1compartment NA NA Human Human +DTXSID1024467 Css NA 0.1081 mg/L 3compartmentss NA 50% Human Human +DTXSID1024467 Css NA 0.7656 mg/L 3compartmentss NA 95% Human Human +DTXSID1024467 Css NA 0.0762 mg/L PBTK NA 50% Human Human +DTXSID1024467 Css NA 0.4981 mg/L PBTK NA 95% Human Human +DTXSID1024467 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024467 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024467 Vd NA 0.8513 L/kg 1compartment NA NA Rat Human DTXSID1024467 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024467 TK.Half.Life NA 2.335 hours 1compartment NA NA Rat Human -DTXSID1024467 Css NA 0.1927 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024467 Css NA 0.7979 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024467 Css NA 0.144 mg/L PBTK NA 50% Rat Human -DTXSID1024467 Css NA 0.5045 mg/L PBTK NA 95% Rat Human +DTXSID1024467 TK.Half.Life NA 0.7489 hours 1compartment NA NA Rat Human +DTXSID1024467 Css NA 0.01374 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024467 Css NA 0.07343 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024467 Css NA 0.009596 mg/L PBTK NA 50% Rat Human +DTXSID1024467 Css NA 0.04715 mg/L PBTK NA 95% Rat Human DTXSID1024598 Clint 841 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1024598 Fup 3.35e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1024598 Vd NA 0.1777 L/kg 1compartment NA NA Human Human +DTXSID1024598 Vd NA 0.2512 L/kg 1compartment NA NA Human Human DTXSID1024598 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024598 TK.Half.Life NA 6.472 hours 1compartment NA NA Human Human -DTXSID1024598 Css NA 2.35 mg/L 3compartmentss NA 50% Human Human -DTXSID1024598 Css NA 16.15 mg/L 3compartmentss NA 95% Human Human -DTXSID1024598 Css NA 1.368 mg/L PBTK NA 50% Human Human -DTXSID1024598 Css NA 9.312 mg/L PBTK NA 95% Human Human +DTXSID1024598 TK.Half.Life NA 5.767 hours 1compartment NA NA Human Human +DTXSID1024598 Css NA 1.436 mg/L 3compartmentss NA 50% Human Human +DTXSID1024598 Css NA 10.25 mg/L 3compartmentss NA 95% Human Human +DTXSID1024598 Css NA 0.8406 mg/L PBTK NA 50% Human Human +DTXSID1024598 Css NA 5.872 mg/L PBTK NA 95% Human Human DTXSID1024598 Clint 841 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1024598 Fup 3.35e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1024598 Vd NA 0.1669 L/kg 1compartment NA NA Rat Human +DTXSID1024598 Vd NA 0.208 L/kg 1compartment NA NA Rat Human DTXSID1024598 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024598 TK.Half.Life NA 4.221 hours 1compartment NA NA Rat Human -DTXSID1024598 Css NA 1.717 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024598 Css NA 6.295 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024598 Css NA 0.9277 mg/L PBTK NA 50% Rat Human -DTXSID1024598 Css NA 3.403 mg/L PBTK NA 95% Rat Human -DTXSID1024621 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024621 Fup NA 0.9521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024621 Vd NA 0.8468 L/kg 1compartment NA NA Human Human +DTXSID1024598 TK.Half.Life NA 3.298 hours 1compartment NA NA Rat Human +DTXSID1024598 Css NA 0.2404 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024598 Css NA 0.9511 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024598 Css NA 0.135 mg/L PBTK NA 50% Rat Human +DTXSID1024598 Css NA 0.5331 mg/L PBTK NA 95% Rat Human +DTXSID1024621 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024621 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024621 Vd NA 0.6254 L/kg 1compartment NA NA Human Human DTXSID1024621 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024621 TK.Half.Life NA 5.771 hours 1compartment NA NA Human Human -DTXSID1024621 Css NA 0.8795 mg/L 3compartmentss NA 50% Human Human -DTXSID1024621 Css NA 5.177 mg/L 3compartmentss NA 95% Human Human -DTXSID1024621 Css NA 0.7458 mg/L PBTK NA 50% Human Human -DTXSID1024621 Css NA 3.379 mg/L PBTK NA 95% Human Human -DTXSID1024621 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024621 Fup NA 0.9521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024621 Vd NA 0.8707 L/kg 1compartment NA NA Rat Human +DTXSID1024621 TK.Half.Life NA 7.074 hours 1compartment NA NA Human Human +DTXSID1024621 Css NA 1.111 mg/L 3compartmentss NA 50% Human Human +DTXSID1024621 Css NA 7.68 mg/L 3compartmentss NA 95% Human Human +DTXSID1024621 Css NA 0.8674 mg/L PBTK NA 50% Human Human +DTXSID1024621 Css NA 4.809 mg/L PBTK NA 95% Human Human +DTXSID1024621 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024621 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024621 Vd NA 0.641 L/kg 1compartment NA NA Rat Human DTXSID1024621 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024621 TK.Half.Life NA 2.018 hours 1compartment NA NA Rat Human -DTXSID1024621 Css NA 0.2222 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024621 Css NA 1.243 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024621 Css NA 0.1844 mg/L PBTK NA 50% Rat Human -DTXSID1024621 Css NA 0.7586 mg/L PBTK NA 95% Rat Human -DTXSID1024625 Clint NA 34.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024625 Fup NA 0.0319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024625 Vd NA 3.085 L/kg 1compartment NA NA Human Human -DTXSID1024625 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID1024625 TK.Half.Life NA 44.29 hours 1compartment NA NA Human Human -DTXSID1024625 Css NA 1.734 mg/L 3compartmentss NA 50% Human Human -DTXSID1024625 Css NA 10.89 mg/L 3compartmentss NA 95% Human Human -DTXSID1024625 Css NA 1.198 mg/L PBTK NA 50% Human Human -DTXSID1024625 Css NA 7.433 mg/L PBTK NA 95% Human Human -DTXSID1024625 Clint NA 34.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024625 Fup NA 0.0319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024625 Vd NA 2.312 L/kg 1compartment NA NA Rat Human -DTXSID1024625 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID1024625 TK.Half.Life NA 6.502 hours 1compartment NA NA Rat Human -DTXSID1024625 Css NA 0.969 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024625 Css NA 5.115 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024625 Css NA 0.6405 mg/L PBTK NA 50% Rat Human -DTXSID1024625 Css NA 3.182 mg/L PBTK NA 95% Rat Human -DTXSID1024629 Clint NA 279.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024629 Fup NA 0.0198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024629 Vd NA 2.733 L/kg 1compartment NA NA Human Human -DTXSID1024629 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024629 TK.Half.Life NA 5.247 hours 1compartment NA NA Human Human -DTXSID1024629 Css NA 0.1568 mg/L 3compartmentss NA 50% Human Human -DTXSID1024629 Css NA 1.13 mg/L 3compartmentss NA 95% Human Human -DTXSID1024629 Css NA 0.1055 mg/L PBTK NA 50% Human Human -DTXSID1024629 Css NA 0.7333 mg/L PBTK NA 95% Human Human -DTXSID1024629 Clint NA 279.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024629 Fup NA 0.0198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024629 Vd NA 2.042 L/kg 1compartment NA NA Rat Human -DTXSID1024629 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024629 TK.Half.Life NA 1.345 hours 1compartment NA NA Rat Human -DTXSID1024629 Css NA 0.08873 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024629 Css NA 0.5431 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024629 Css NA 0.05689 mg/L PBTK NA 50% Rat Human -DTXSID1024629 Css NA 0.3334 mg/L PBTK NA 95% Rat Human -DTXSID1024831 Clint NA 0.00299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024831 Fup NA 0.4019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024831 Vd NA 0.387 L/kg 1compartment NA NA Human Human +DTXSID1024621 TK.Half.Life NA 2.467 hours 1compartment NA NA Rat Human +DTXSID1024621 Css NA 0.02112 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024621 Css NA 0.183 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024621 Css NA 0.0159 mg/L PBTK NA 50% Rat Human +DTXSID1024621 Css NA 0.1114 mg/L PBTK NA 95% Rat Human +DTXSID1024625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024625 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024625 Vd NA 3.028 L/kg 1compartment NA NA Human Human +DTXSID1024625 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID1024625 TK.Half.Life NA 71.68 hours 1compartment NA NA Human Human +DTXSID1024625 Css NA 2.916 mg/L 3compartmentss NA 50% Human Human +DTXSID1024625 Css NA 19.24 mg/L 3compartmentss NA 95% Human Human +DTXSID1024625 Css NA 1.992 mg/L PBTK NA 50% Human Human +DTXSID1024625 Css NA 12.68 mg/L PBTK NA 95% Human Human +DTXSID1024625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024625 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024625 Vd NA 2.267 L/kg 1compartment NA NA Rat Human +DTXSID1024625 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID1024625 TK.Half.Life NA 10.93 hours 1compartment NA NA Rat Human +DTXSID1024625 Css NA 0.3794 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024625 Css NA 2.175 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024625 Css NA 0.2571 mg/L PBTK NA 50% Rat Human +DTXSID1024625 Css NA 1.426 mg/L PBTK NA 95% Rat Human +DTXSID1024629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024629 Fup 0.0108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024629 Vd NA 1.934 L/kg 1compartment NA NA Human Human +DTXSID1024629 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1024629 TK.Half.Life NA 28.68 hours 1compartment NA NA Human Human +DTXSID1024629 Css NA 2.28 mg/L 3compartmentss NA 50% Human Human +DTXSID1024629 Css NA 18.49 mg/L 3compartmentss NA 95% Human Human +DTXSID1024629 Css NA 1.455 mg/L PBTK NA 50% Human Human +DTXSID1024629 Css NA 11.32 mg/L PBTK NA 95% Human Human +DTXSID1024629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024629 Fup 0.0108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024629 Vd NA 1.432 L/kg 1compartment NA NA Rat Human +DTXSID1024629 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1024629 TK.Half.Life NA 9.427 hours 1compartment NA NA Rat Human +DTXSID1024629 Css NA 0.298 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024629 Css NA 2.082 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024629 Css NA 0.1856 mg/L PBTK NA 50% Rat Human +DTXSID1024629 Css NA 1.237 mg/L PBTK NA 95% Rat Human +DTXSID1024702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024702 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024702 Vd NA 2.132 L/kg 1compartment NA NA Human Human +DTXSID1024702 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1024702 TK.Half.Life NA 14.14 hours 1compartment NA NA Human Human +DTXSID1024702 Css NA 0.9194 mg/L 3compartmentss NA 50% Human Human +DTXSID1024702 Css NA 6.902 mg/L 3compartmentss NA 95% Human Human +DTXSID1024702 Css NA 0.6006 mg/L PBTK NA 50% Human Human +DTXSID1024702 Css NA 4.295 mg/L PBTK NA 95% Human Human +DTXSID1024702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024702 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024702 Vd NA 1.595 L/kg 1compartment NA NA Rat Human +DTXSID1024702 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1024702 TK.Half.Life NA 4.34 hours 1compartment NA NA Rat Human +DTXSID1024702 Css NA 0.1165 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024702 Css NA 0.7398 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024702 Css NA 0.07511 mg/L PBTK NA 50% Rat Human +DTXSID1024702 Css NA 0.4524 mg/L PBTK NA 95% Rat Human +DTXSID1024831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024831 Fup 0.538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024831 Vd NA 0.5518 L/kg 1compartment NA NA Human Human DTXSID1024831 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024831 TK.Half.Life NA 6.2 hours 1compartment NA NA Human Human -DTXSID1024831 Css NA 1.909 mg/L 3compartmentss NA 50% Human Human -DTXSID1024831 Css NA 8.387 mg/L 3compartmentss NA 95% Human Human -DTXSID1024831 Css NA 1.324 mg/L PBTK NA 50% Human Human -DTXSID1024831 Css NA 5.161 mg/L PBTK NA 95% Human Human -DTXSID1024831 Clint NA 0.00299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024831 Fup NA 0.4019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024831 Vd NA 0.3927 L/kg 1compartment NA NA Rat Human +DTXSID1024831 TK.Half.Life NA 0.5291 hours 1compartment NA NA Human Human +DTXSID1024831 Css NA 0.03501 mg/L 3compartmentss NA 50% Human Human +DTXSID1024831 Css NA 0.3448 mg/L 3compartmentss NA 95% Human Human +DTXSID1024831 Css NA 0.02652 mg/L PBTK NA 50% Human Human +DTXSID1024831 Css NA 0.2321 mg/L PBTK NA 95% Human Human +DTXSID1024831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024831 Fup 0.538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024831 Vd NA 0.5687 L/kg 1compartment NA NA Rat Human DTXSID1024831 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024831 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human -DTXSID1024831 Css NA 0.527 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024831 Css NA 1.945 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024831 Css NA 0.348 mg/L PBTK NA 50% Rat Human -DTXSID1024831 Css NA 1.123 mg/L PBTK NA 95% Rat Human -DTXSID1024881 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024881 Fup NA 0.9427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024881 Vd NA 1.11 L/kg 1compartment NA NA Human Human +DTXSID1024831 TK.Half.Life NA 0.2711 hours 1compartment NA NA Rat Human +DTXSID1024831 Css NA 0.00431 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024831 Css NA 0.03497 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024831 Css NA 0.003261 mg/L PBTK NA 50% Rat Human +DTXSID1024831 Css NA 0.02258 mg/L PBTK NA 95% Rat Human +DTXSID1024835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024835 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024835 Vd NA 1.033 L/kg 1compartment NA NA Human Human +DTXSID1024835 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1024835 TK.Half.Life NA 1.692 hours 1compartment NA NA Human Human +DTXSID1024835 Css NA 0.1064 mg/L 3compartmentss NA 50% Human Human +DTXSID1024835 Css NA 0.7411 mg/L 3compartmentss NA 95% Human Human +DTXSID1024835 Css NA 0.07484 mg/L PBTK NA 50% Human Human +DTXSID1024835 Css NA 0.4968 mg/L PBTK NA 95% Human Human +DTXSID1024835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024835 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024835 Vd NA 0.852 L/kg 1compartment NA NA Rat Human +DTXSID1024835 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1024835 TK.Half.Life NA 0.7393 hours 1compartment NA NA Rat Human +DTXSID1024835 Css NA 0.0136 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024835 Css NA 0.07067 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024835 Css NA 0.00946 mg/L PBTK NA 50% Rat Human +DTXSID1024835 Css NA 0.04659 mg/L PBTK NA 95% Rat Human +DTXSID1024837 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024837 Fup 0.0795 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024837 Vd NA 3.08 L/kg 1compartment NA NA Human Human +DTXSID1024837 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID1024837 TK.Half.Life NA 48.3 hours 1compartment NA NA Human Human +DTXSID1024837 Css NA 1.803 mg/L 3compartmentss NA 50% Human Human +DTXSID1024837 Css NA 11.73 mg/L 3compartmentss NA 95% Human Human +DTXSID1024837 Css NA 1.257 mg/L PBTK NA 50% Human Human +DTXSID1024837 Css NA 8.062 mg/L PBTK NA 95% Human Human +DTXSID1024837 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024837 Fup 0.0795 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024837 Vd NA 2.309 L/kg 1compartment NA NA Rat Human +DTXSID1024837 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1024837 TK.Half.Life NA 7.123 hours 1compartment NA NA Rat Human +DTXSID1024837 Css NA 0.2358 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024837 Css NA 1.293 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024837 Css NA 0.1619 mg/L PBTK NA 50% Rat Human +DTXSID1024837 Css NA 0.8569 mg/L PBTK NA 95% Rat Human +DTXSID1024881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024881 Fup 0.548 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024881 Vd NA 0.7994 L/kg 1compartment NA NA Human Human DTXSID1024881 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024881 TK.Half.Life NA 7.831 hours 1compartment NA NA Human Human -DTXSID1024881 Css NA 0.8534 mg/L 3compartmentss NA 50% Human Human -DTXSID1024881 Css NA 4.9 mg/L 3compartmentss NA 95% Human Human -DTXSID1024881 Css NA 0.7595 mg/L PBTK NA 50% Human Human -DTXSID1024881 Css NA 3.337 mg/L PBTK NA 95% Human Human -DTXSID1024881 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024881 Fup NA 0.9427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024881 Vd NA 1.081 L/kg 1compartment NA NA Rat Human +DTXSID1024881 TK.Half.Life NA 9.591 hours 1compartment NA NA Human Human +DTXSID1024881 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human +DTXSID1024881 Css NA 7.25 mg/L 3compartmentss NA 95% Human Human +DTXSID1024881 Css NA 0.8974 mg/L PBTK NA 50% Human Human +DTXSID1024881 Css NA 4.618 mg/L PBTK NA 95% Human Human +DTXSID1024881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024881 Fup 0.548 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024881 Vd NA 0.7753 L/kg 1compartment NA NA Rat Human DTXSID1024881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024881 TK.Half.Life NA 2.546 hours 1compartment NA NA Rat Human -DTXSID1024881 Css NA 0.214 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024881 Css NA 1.223 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024881 Css NA 0.1876 mg/L PBTK NA 50% Rat Human -DTXSID1024881 Css NA 0.7623 mg/L PBTK NA 95% Rat Human -DTXSID1024885 Clint NA 5.156 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024885 Fup NA 0.0953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024885 Vd NA 1.539 L/kg 1compartment NA NA Human Human -DTXSID1024885 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1024885 TK.Half.Life NA 14.16 hours 1compartment NA NA Human Human -DTXSID1024885 Css NA 1.314 mg/L 3compartmentss NA 50% Human Human -DTXSID1024885 Css NA 8.074 mg/L 3compartmentss NA 95% Human Human -DTXSID1024885 Css NA 0.8689 mg/L PBTK NA 50% Human Human -DTXSID1024885 Css NA 5.016 mg/L PBTK NA 95% Human Human -DTXSID1024885 Clint NA 5.156 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024885 Fup NA 0.0953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024885 Vd NA 1.175 L/kg 1compartment NA NA Rat Human +DTXSID1024881 TK.Half.Life NA 3.132 hours 1compartment NA NA Rat Human +DTXSID1024881 Css NA 0.02102 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024881 Css NA 0.1752 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024881 Css NA 0.01634 mg/L PBTK NA 50% Rat Human +DTXSID1024881 Css NA 0.1122 mg/L PBTK NA 95% Rat Human +DTXSID1024885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024885 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024885 Vd NA 1.689 L/kg 1compartment NA NA Human Human +DTXSID1024885 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1024885 TK.Half.Life NA 4.539 hours 1compartment NA NA Human Human +DTXSID1024885 Css NA 0.2749 mg/L 3compartmentss NA 50% Human Human +DTXSID1024885 Css NA 2.051 mg/L 3compartmentss NA 95% Human Human +DTXSID1024885 Css NA 0.1856 mg/L PBTK NA 50% Human Human +DTXSID1024885 Css NA 1.308 mg/L PBTK NA 95% Human Human +DTXSID1024885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024885 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024885 Vd NA 1.292 L/kg 1compartment NA NA Rat Human DTXSID1024885 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024885 TK.Half.Life NA 5.291 hours 1compartment NA NA Rat Human -DTXSID1024885 Css NA 0.6835 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024885 Css NA 3.103 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024885 Css NA 0.4288 mg/L PBTK NA 50% Rat Human -DTXSID1024885 Css NA 1.807 mg/L PBTK NA 95% Rat Human -DTXSID1024887 Clint NA 15.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024887 Fup NA 0.0362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024887 Vd NA 3.054 L/kg 1compartment NA NA Human Human -DTXSID1024887 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID1024887 TK.Half.Life NA 81.51 hours 1compartment NA NA Human Human -DTXSID1024887 Css NA 3.321 mg/L 3compartmentss NA 50% Human Human -DTXSID1024887 Css NA 21.27 mg/L 3compartmentss NA 95% Human Human -DTXSID1024887 Css NA 2.303 mg/L PBTK NA 50% Human Human -DTXSID1024887 Css NA 14.2 mg/L PBTK NA 95% Human Human -DTXSID1024887 Clint NA 15.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024887 Fup NA 0.0362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024887 Vd NA 2.287 L/kg 1compartment NA NA Rat Human -DTXSID1024887 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID1024887 TK.Half.Life NA 12.01 hours 1compartment NA NA Rat Human -DTXSID1024887 Css NA 1.847 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024887 Css NA 9.418 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024887 Css NA 1.219 mg/L PBTK NA 50% Rat Human -DTXSID1024887 Css NA 6.125 mg/L PBTK NA 95% Rat Human -DTXSID1024916 Clint NA 2.327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024916 Fup NA 0.7629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024916 Vd NA 1.054 L/kg 1compartment NA NA Human Human -DTXSID1024916 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024916 TK.Half.Life NA 2.275 hours 1compartment NA NA Human Human -DTXSID1024916 Css NA 0.2095 mg/L 3compartmentss NA 50% Human Human -DTXSID1024916 Css NA 1.526 mg/L 3compartmentss NA 95% Human Human -DTXSID1024916 Css NA 0.1814 mg/L PBTK NA 50% Human Human -DTXSID1024916 Css NA 1.03 mg/L PBTK NA 95% Human Human -DTXSID1024916 Clint NA 2.327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024916 Fup NA 0.7629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024916 Vd NA 1.007 L/kg 1compartment NA NA Rat Human +DTXSID1024885 TK.Half.Life NA 1.674 hours 1compartment NA NA Rat Human +DTXSID1024885 Css NA 0.03528 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024885 Css NA 0.2089 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024885 Css NA 0.02336 mg/L PBTK NA 50% Rat Human +DTXSID1024885 Css NA 0.1299 mg/L PBTK NA 95% Rat Human +DTXSID1024916 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024916 Fup 0.557 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024916 Vd NA 1.953 L/kg 1compartment NA NA Human Human +DTXSID1024916 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1024916 TK.Half.Life NA 33.93 hours 1compartment NA NA Human Human +DTXSID1024916 Css NA 1.709 mg/L 3compartmentss NA 50% Human Human +DTXSID1024916 Css NA 9.341 mg/L 3compartmentss NA 95% Human Human +DTXSID1024916 Css NA 1.463 mg/L PBTK NA 50% Human Human +DTXSID1024916 Css NA 6.131 mg/L PBTK NA 95% Human Human +DTXSID1024916 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024916 Fup 0.557 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024916 Vd NA 1.597 L/kg 1compartment NA NA Rat Human DTXSID1024916 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024916 TK.Half.Life NA 1.123 hours 1compartment NA NA Rat Human -DTXSID1024916 Css NA 0.09011 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024916 Css NA 0.6433 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024916 Css NA 0.07667 mg/L PBTK NA 50% Rat Human -DTXSID1024916 Css NA 0.3933 mg/L PBTK NA 95% Rat Human -DTXSID1024918 Clint NA 0.5883 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024918 Fup NA 0.7548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024918 Vd NA 3.321 L/kg 1compartment NA NA Human Human -DTXSID1024918 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1024918 TK.Half.Life NA 14.62 hours 1compartment NA NA Human Human -DTXSID1024918 Css NA 0.34 mg/L 3compartmentss NA 50% Human Human -DTXSID1024918 Css NA 2.772 mg/L 3compartmentss NA 95% Human Human -DTXSID1024918 Css NA 0.4218 mg/L PBTK NA 50% Human Human -DTXSID1024918 Css NA 2.071 mg/L PBTK NA 95% Human Human -DTXSID1024918 Clint NA 0.5883 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024918 Fup NA 0.7548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024918 Vd NA 3.38 L/kg 1compartment NA NA Rat Human -DTXSID1024918 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024918 TK.Half.Life NA 6.723 hours 1compartment NA NA Rat Human -DTXSID1024918 Css NA 0.115 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024918 Css NA 1.006 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024918 Css NA 0.1436 mg/L PBTK NA 50% Rat Human -DTXSID1024918 Css NA 0.6966 mg/L PBTK NA 95% Rat Human -DTXSID1024966 Clint NA 7.079 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024966 Fup NA 0.1755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1024966 Vd NA 1.986 L/kg 1compartment NA NA Human Human +DTXSID1024916 TK.Half.Life NA 7.069 hours 1compartment NA NA Rat Human +DTXSID1024916 Css NA 0.1051 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024916 Css NA 0.5438 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024916 Css NA 0.09032 mg/L PBTK NA 50% Rat Human +DTXSID1024916 Css NA 0.3466 mg/L PBTK NA 95% Rat Human +DTXSID1024918 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024918 Fup 0.742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024918 Vd NA 3.281 L/kg 1compartment NA NA Human Human +DTXSID1024918 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1024918 TK.Half.Life NA 28.65 hours 1compartment NA NA Human Human +DTXSID1024918 Css NA 0.5844 mg/L 3compartmentss NA 50% Human Human +DTXSID1024918 Css NA 4.9 mg/L 3compartmentss NA 95% Human Human +DTXSID1024918 Css NA 0.723 mg/L PBTK NA 50% Human Human +DTXSID1024918 Css NA 3.569 mg/L PBTK NA 95% Human Human +DTXSID1024918 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024918 Fup 0.742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024918 Vd NA 3.337 L/kg 1compartment NA NA Rat Human +DTXSID1024918 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1024918 TK.Half.Life NA 9.919 hours 1compartment NA NA Rat Human +DTXSID1024918 Css NA 0.0108 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024918 Css NA 0.1213 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024918 Css NA 0.01289 mg/L PBTK NA 50% Rat Human +DTXSID1024918 Css NA 0.09253 mg/L PBTK NA 95% Rat Human +DTXSID1024966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024966 Fup 0.083 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1024966 Vd NA 1.459 L/kg 1compartment NA NA Human Human DTXSID1024966 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1024966 TK.Half.Life NA 9.939 hours 1compartment NA NA Human Human -DTXSID1024966 Css NA 0.5382 mg/L 3compartmentss NA 50% Human Human -DTXSID1024966 Css NA 3.032 mg/L 3compartmentss NA 95% Human Human -DTXSID1024966 Css NA 0.3843 mg/L PBTK NA 50% Human Human -DTXSID1024966 Css NA 2.023 mg/L PBTK NA 95% Human Human -DTXSID1024966 Clint NA 7.079 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024966 Fup NA 0.1755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1024966 Vd NA 1.527 L/kg 1compartment NA NA Rat Human +DTXSID1024966 TK.Half.Life NA 4.696 hours 1compartment NA NA Human Human +DTXSID1024966 Css NA 0.3721 mg/L 3compartmentss NA 50% Human Human +DTXSID1024966 Css NA 2.826 mg/L 3compartmentss NA 95% Human Human +DTXSID1024966 Css NA 0.2428 mg/L PBTK NA 50% Human Human +DTXSID1024966 Css NA 1.762 mg/L PBTK NA 95% Human Human +DTXSID1024966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024966 Fup 0.083 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1024966 Vd NA 1.112 L/kg 1compartment NA NA Rat Human DTXSID1024966 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1024966 TK.Half.Life NA 3.29 hours 1compartment NA NA Rat Human -DTXSID1024966 Css NA 0.2832 mg/L 3compartmentss NA 50% Rat Human -DTXSID1024966 Css NA 1.145 mg/L 3compartmentss NA 95% Rat Human -DTXSID1024966 Css NA 0.1937 mg/L PBTK NA 50% Rat Human -DTXSID1024966 Css NA 0.7402 mg/L PBTK NA 95% Rat Human -DTXSID1025013 Clint NA 4.262 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025013 Fup NA 0.0921 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025013 Vd NA 1.295 L/kg 1compartment NA NA Human Human -DTXSID1025013 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1025013 TK.Half.Life NA 13.42 hours 1compartment NA NA Human Human -DTXSID1025013 Css NA 1.521 mg/L 3compartmentss NA 50% Human Human -DTXSID1025013 Css NA 9.275 mg/L 3compartmentss NA 95% Human Human -DTXSID1025013 Css NA 0.9918 mg/L PBTK NA 50% Human Human -DTXSID1025013 Css NA 5.716 mg/L PBTK NA 95% Human Human -DTXSID1025013 Clint NA 4.262 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025013 Fup NA 0.0921 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025013 Vd NA 0.9961 L/kg 1compartment NA NA Rat Human +DTXSID1024966 TK.Half.Life NA 1.838 hours 1compartment NA NA Rat Human +DTXSID1024966 Css NA 0.04822 mg/L 3compartmentss NA 50% Rat Human +DTXSID1024966 Css NA 0.2822 mg/L 3compartmentss NA 95% Rat Human +DTXSID1024966 Css NA 0.03092 mg/L PBTK NA 50% Rat Human +DTXSID1024966 Css NA 0.1713 mg/L PBTK NA 95% Rat Human +DTXSID1025013 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025013 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025013 Vd NA 1.288 L/kg 1compartment NA NA Human Human +DTXSID1025013 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1025013 TK.Half.Life NA 8.146 hours 1compartment NA NA Human Human +DTXSID1025013 Css NA 0.8368 mg/L 3compartmentss NA 50% Human Human +DTXSID1025013 Css NA 5.65 mg/L 3compartmentss NA 95% Human Human +DTXSID1025013 Css NA 0.5505 mg/L PBTK NA 50% Human Human +DTXSID1025013 Css NA 3.534 mg/L PBTK NA 95% Human Human +DTXSID1025013 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025013 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025013 Vd NA 1 L/kg 1compartment NA NA Rat Human DTXSID1025013 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025013 TK.Half.Life NA 5.336 hours 1compartment NA NA Rat Human -DTXSID1025013 Css NA 0.7738 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025013 Css NA 3.652 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025013 Css NA 0.4778 mg/L PBTK NA 50% Rat Human -DTXSID1025013 Css NA 2.087 mg/L PBTK NA 95% Rat Human -DTXSID1025063 Clint NA 0.1034 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025063 Fup NA 0.7587 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025063 Vd NA 1.041 L/kg 1compartment NA NA Human Human +DTXSID1025013 TK.Half.Life NA 3.344 hours 1compartment NA NA Rat Human +DTXSID1025013 Css NA 0.1018 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025013 Css NA 0.5033 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025013 Css NA 0.06615 mg/L PBTK NA 50% Rat Human +DTXSID1025013 Css NA 0.3019 mg/L PBTK NA 95% Rat Human +DTXSID1025017 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025017 Fup 0.00573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025017 Vd NA 2.992 L/kg 1compartment NA NA Human Human +DTXSID1025017 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID1025017 TK.Half.Life NA 82.46 hours 1compartment NA NA Human Human +DTXSID1025017 Css NA 3.492 mg/L 3compartmentss NA 50% Human Human +DTXSID1025017 Css NA 22.68 mg/L 3compartmentss NA 95% Human Human +DTXSID1025017 Css NA 2.386 mg/L PBTK NA 50% Human Human +DTXSID1025017 Css NA 15.1 mg/L PBTK NA 95% Human Human +DTXSID1025017 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025017 Fup 0.00573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025017 Vd NA 2.238 L/kg 1compartment NA NA Rat Human +DTXSID1025017 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID1025017 TK.Half.Life NA 13.05 hours 1compartment NA NA Rat Human +DTXSID1025017 Css NA 0.451 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025017 Css NA 2.406 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025017 Css NA 0.305 mg/L PBTK NA 50% Rat Human +DTXSID1025017 Css NA 1.608 mg/L PBTK NA 95% Rat Human +DTXSID1025063 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025063 Fup 0.809 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025063 Vd NA 1.123 L/kg 1compartment NA NA Human Human DTXSID1025063 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025063 TK.Half.Life NA 7.815 hours 1compartment NA NA Human Human -DTXSID1025063 Css NA 0.8101 mg/L 3compartmentss NA 50% Human Human -DTXSID1025063 Css NA 5.031 mg/L 3compartmentss NA 95% Human Human -DTXSID1025063 Css NA 0.7068 mg/L PBTK NA 50% Human Human -DTXSID1025063 Css NA 3.312 mg/L PBTK NA 95% Human Human -DTXSID1025063 Clint NA 0.1034 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025063 Fup NA 0.7587 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025063 Vd NA 1 L/kg 1compartment NA NA Rat Human +DTXSID1025063 TK.Half.Life NA 9.339 hours 1compartment NA NA Human Human +DTXSID1025063 Css NA 0.9026 mg/L 3compartmentss NA 50% Human Human +DTXSID1025063 Css NA 5.63 mg/L 3compartmentss NA 95% Human Human +DTXSID1025063 Css NA 0.7984 mg/L PBTK NA 50% Human Human +DTXSID1025063 Css NA 3.789 mg/L PBTK NA 95% Human Human +DTXSID1025063 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025063 Fup 0.809 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025063 Vd NA 1.071 L/kg 1compartment NA NA Rat Human DTXSID1025063 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025063 TK.Half.Life NA 2.702 hours 1compartment NA NA Rat Human -DTXSID1025063 Css NA 0.2304 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025063 Css NA 1.519 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025063 Css NA 0.1954 mg/L PBTK NA 50% Rat Human -DTXSID1025063 Css NA 0.9197 mg/L PBTK NA 95% Rat Human +DTXSID1025063 TK.Half.Life NA 2.947 hours 1compartment NA NA Rat Human +DTXSID1025063 Css NA 0.05278 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025063 Css NA 0.3152 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025063 Css NA 0.04746 mg/L PBTK NA 50% Rat Human +DTXSID1025063 Css NA 0.2015 mg/L PBTK NA 95% Rat Human DTXSID1025065 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1025065 Fup NA 0.1814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025065 Vd NA 0.301 L/kg 1compartment NA NA Human Human +DTXSID1025065 Vd NA 0.3702 L/kg 1compartment NA NA Human Human DTXSID1025065 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1025065 TK.Half.Life NA 10.74 hours 1compartment NA NA Human Human -DTXSID1025065 Css NA 4.531 mg/L 3compartmentss NA 50% Human Human -DTXSID1025065 Css NA 15.9 mg/L 3compartmentss NA 95% Human Human -DTXSID1025065 Css NA 2.883 mg/L PBTK NA 50% Human Human -DTXSID1025065 Css NA 9.535 mg/L PBTK NA 95% Human Human +DTXSID1025065 TK.Half.Life NA 13.23 hours 1compartment NA NA Human Human +DTXSID1025065 Css NA 3.756 mg/L 3compartmentss NA 50% Human Human +DTXSID1025065 Css NA 13.68 mg/L 3compartmentss NA 95% Human Human +DTXSID1025065 Css NA 2.442 mg/L PBTK NA 50% Human Human +DTXSID1025065 Css NA 8.293 mg/L PBTK NA 95% Human Human DTXSID1025065 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1025065 Fup NA 0.1814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025065 Vd NA 0.3141 L/kg 1compartment NA NA Rat Human +DTXSID1025065 Vd NA 0.3702 L/kg 1compartment NA NA Rat Human DTXSID1025065 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025065 TK.Half.Life NA 3.817 hours 1compartment NA NA Rat Human -DTXSID1025065 Css NA 1.261 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025065 Css NA 3.664 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025065 Css NA 0.7591 mg/L PBTK NA 50% Rat Human -DTXSID1025065 Css NA 2.062 mg/L PBTK NA 95% Rat Human -DTXSID1025148 Clint NA 7.725 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025148 Fup NA 0.3194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025148 Vd NA 1.845 L/kg 1compartment NA NA Human Human +DTXSID1025065 TK.Half.Life NA 4.501 hours 1compartment NA NA Rat Human +DTXSID1025065 Css NA 0.06773 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025065 Css NA 0.3856 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025065 Css NA 0.04216 mg/L PBTK NA 50% Rat Human +DTXSID1025065 Css NA 0.23 mg/L PBTK NA 95% Rat Human +DTXSID1025148 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025148 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025148 Vd NA 1.646 L/kg 1compartment NA NA Human Human DTXSID1025148 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025148 TK.Half.Life NA 4.868 hours 1compartment NA NA Human Human -DTXSID1025148 Css NA 0.2324 mg/L 3compartmentss NA 50% Human Human -DTXSID1025148 Css NA 1.362 mg/L 3compartmentss NA 95% Human Human -DTXSID1025148 Css NA 0.1788 mg/L PBTK NA 50% Human Human -DTXSID1025148 Css NA 0.959 mg/L PBTK NA 95% Human Human -DTXSID1025148 Clint NA 7.725 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025148 Fup NA 0.3194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025148 Vd NA 1.464 L/kg 1compartment NA NA Rat Human +DTXSID1025148 TK.Half.Life NA 2.646 hours 1compartment NA NA Human Human +DTXSID1025148 Css NA 0.08535 mg/L 3compartmentss NA 50% Human Human +DTXSID1025148 Css NA 0.6381 mg/L 3compartmentss NA 95% Human Human +DTXSID1025148 Css NA 0.06288 mg/L PBTK NA 50% Human Human +DTXSID1025148 Css NA 0.4451 mg/L PBTK NA 95% Human Human +DTXSID1025148 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025148 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025148 Vd NA 1.302 L/kg 1compartment NA NA Rat Human DTXSID1025148 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025148 TK.Half.Life NA 1.778 hours 1compartment NA NA Rat Human -DTXSID1025148 Css NA 0.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025148 Css NA 0.5383 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025148 Css NA 0.08884 mg/L PBTK NA 50% Rat Human -DTXSID1025148 Css NA 0.3615 mg/L PBTK NA 95% Rat Human +DTXSID1025148 TK.Half.Life NA 1.006 hours 1compartment NA NA Rat Human +DTXSID1025148 Css NA 0.003054 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025148 Css NA 0.02577 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025148 Css NA 0.002228 mg/L PBTK NA 50% Rat Human +DTXSID1025148 Css NA 0.01727 mg/L PBTK NA 95% Rat Human DTXSID1025271 Clint 21.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1025271 Fup 0.214 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1025271 Vd NA 1.321 L/kg 1compartment NA NA Human Human DTXSID1025271 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1025271 TK.Half.Life NA 2.178 hours 1compartment NA NA Human Human -DTXSID1025271 Css NA 0.1075 mg/L 3compartmentss NA 50% Human Human -DTXSID1025271 Css NA 0.6476 mg/L 3compartmentss NA 95% Human Human -DTXSID1025271 Css NA 0.07764 mg/L PBTK NA 50% Human Human -DTXSID1025271 Css NA 0.4435 mg/L PBTK NA 95% Human Human +DTXSID1025271 Css NA 0.1039 mg/L 3compartmentss NA 50% Human Human +DTXSID1025271 Css NA 0.6329 mg/L 3compartmentss NA 95% Human Human +DTXSID1025271 Css NA 0.07478 mg/L PBTK NA 50% Human Human +DTXSID1025271 Css NA 0.441 mg/L PBTK NA 95% Human Human DTXSID1025271 Clint 21.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1025271 Fup 0.214 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1025271 Vd NA 1.063 L/kg 1compartment NA NA Rat Human DTXSID1025271 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1025271 TK.Half.Life NA 0.895 hours 1compartment NA NA Rat Human -DTXSID1025271 Css NA 0.05834 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025271 Css NA 0.2643 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025271 Css NA 0.04033 mg/L PBTK NA 50% Rat Human -DTXSID1025271 Css NA 0.1795 mg/L PBTK NA 95% Rat Human -DTXSID1025279 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025279 Fup NA 0.8952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025279 Vd NA 1.234 L/kg 1compartment NA NA Human Human +DTXSID1025271 Css NA 0.01293 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025271 Css NA 0.06309 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025271 Css NA 0.009236 mg/L PBTK NA 50% Rat Human +DTXSID1025271 Css NA 0.04375 mg/L PBTK NA 95% Rat Human +DTXSID1025279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025279 Fup 0.52 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025279 Vd NA 0.808 L/kg 1compartment NA NA Human Human DTXSID1025279 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025279 TK.Half.Life NA 9.404 hours 1compartment NA NA Human Human -DTXSID1025279 Css NA 0.824 mg/L 3compartmentss NA 50% Human Human -DTXSID1025279 Css NA 3.361 mg/L 3compartmentss NA 95% Human Human -DTXSID1025279 Css NA 0.7574 mg/L PBTK NA 50% Human Human -DTXSID1025279 Css NA 2.427 mg/L PBTK NA 95% Human Human -DTXSID1025279 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025279 Fup NA 0.8952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025279 Vd NA 1.166 L/kg 1compartment NA NA Rat Human +DTXSID1025279 TK.Half.Life NA 0.782 hours 1compartment NA NA Human Human +DTXSID1025279 Css NA 0.0368 mg/L 3compartmentss NA 50% Human Human +DTXSID1025279 Css NA 0.3613 mg/L 3compartmentss NA 95% Human Human +DTXSID1025279 Css NA 0.02902 mg/L PBTK NA 50% Human Human +DTXSID1025279 Css NA 0.2431 mg/L PBTK NA 95% Human Human +DTXSID1025279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025279 Fup 0.52 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025279 Vd NA 0.7765 L/kg 1compartment NA NA Rat Human DTXSID1025279 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025279 TK.Half.Life NA 2.909 hours 1compartment NA NA Rat Human -DTXSID1025279 Css NA 0.2102 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025279 Css NA 0.8138 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025279 Css NA 0.1894 mg/L PBTK NA 50% Rat Human -DTXSID1025279 Css NA 0.5421 mg/L PBTK NA 95% Rat Human -DTXSID1025302 Clint NA 64.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025302 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025302 Vd NA 3.023 L/kg 1compartment NA NA Human Human -DTXSID1025302 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1025302 TK.Half.Life NA 25.47 hours 1compartment NA NA Human Human -DTXSID1025302 Css NA 1.003 mg/L 3compartmentss NA 50% Human Human -DTXSID1025302 Css NA 6.293 mg/L 3compartmentss NA 95% Human Human -DTXSID1025302 Css NA 0.6914 mg/L PBTK NA 50% Human Human -DTXSID1025302 Css NA 4.207 mg/L PBTK NA 95% Human Human -DTXSID1025302 Clint NA 64.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025302 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025302 Vd NA 2.263 L/kg 1compartment NA NA Rat Human -DTXSID1025302 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1025302 TK.Half.Life NA 4.211 hours 1compartment NA NA Rat Human -DTXSID1025302 Css NA 0.5619 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025302 Css NA 2.982 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025302 Css NA 0.3674 mg/L PBTK NA 50% Rat Human -DTXSID1025302 Css NA 1.92 mg/L PBTK NA 95% Rat Human -DTXSID1025304 Clint NA 47.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025304 Fup NA 0.3377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025304 Vd NA 3.74 L/kg 1compartment NA NA Human Human +DTXSID1025279 TK.Half.Life NA 0.3771 hours 1compartment NA NA Rat Human +DTXSID1025279 Css NA 0.004491 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025279 Css NA 0.03448 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025279 Css NA 0.003591 mg/L PBTK NA 50% Rat Human +DTXSID1025279 Css NA 0.02287 mg/L PBTK NA 95% Rat Human +DTXSID1025302 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025302 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025302 Vd NA 3.12 L/kg 1compartment NA NA Human Human +DTXSID1025302 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID1025302 TK.Half.Life NA 94.27 hours 1compartment NA NA Human Human +DTXSID1025302 Css NA 3.418 mg/L 3compartmentss NA 50% Human Human +DTXSID1025302 Css NA 20.59 mg/L 3compartmentss NA 95% Human Human +DTXSID1025302 Css NA 2.367 mg/L PBTK NA 50% Human Human +DTXSID1025302 Css NA 14.33 mg/L PBTK NA 95% Human Human +DTXSID1025302 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025302 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025302 Vd NA 2.337 L/kg 1compartment NA NA Rat Human +DTXSID1025302 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID1025302 TK.Half.Life NA 12.63 hours 1compartment NA NA Rat Human +DTXSID1025302 Css NA 0.4472 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025302 Css NA 2.224 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025302 Css NA 0.3061 mg/L PBTK NA 50% Rat Human +DTXSID1025302 Css NA 1.555 mg/L PBTK NA 95% Rat Human +DTXSID1025304 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025304 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025304 Vd NA 3.036 L/kg 1compartment NA NA Human Human DTXSID1025304 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025304 TK.Half.Life NA 1.942 hours 1compartment NA NA Human Human -DTXSID1025304 Css NA 0.009895 mg/L 3compartmentss NA 50% Human Human -DTXSID1025304 Css NA 0.09833 mg/L 3compartmentss NA 95% Human Human -DTXSID1025304 Css NA 0.01395 mg/L PBTK NA 50% Human Human -DTXSID1025304 Css NA 0.1028 mg/L PBTK NA 95% Human Human -DTXSID1025304 Clint NA 47.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025304 Fup NA 0.3377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025304 Vd NA 3.721 L/kg 1compartment NA NA Rat Human +DTXSID1025304 TK.Half.Life NA 2.166 hours 1compartment NA NA Human Human +DTXSID1025304 Css NA 0.02159 mg/L 3compartmentss NA 50% Human Human +DTXSID1025304 Css NA 0.2445 mg/L 3compartmentss NA 95% Human Human +DTXSID1025304 Css NA 0.02739 mg/L PBTK NA 50% Human Human +DTXSID1025304 Css NA 0.2244 mg/L PBTK NA 95% Human Human +DTXSID1025304 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025304 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025304 Vd NA 3.013 L/kg 1compartment NA NA Rat Human DTXSID1025304 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025304 TK.Half.Life NA 0.9792 hours 1compartment NA NA Rat Human -DTXSID1025304 Css NA 0.00509 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025304 Css NA 0.04216 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025304 Css NA 0.007322 mg/L PBTK NA 50% Rat Human -DTXSID1025304 Css NA 0.04336 mg/L PBTK NA 95% Rat Human -DTXSID1025431 Clint NA 14.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025431 Fup NA 0.072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025431 Vd NA 1.623 L/kg 1compartment NA NA Human Human +DTXSID1025304 TK.Half.Life NA 1.153 hours 1compartment NA NA Rat Human +DTXSID1025304 Css NA 0.00256 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025304 Css NA 0.02237 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025304 Css NA 0.003406 mg/L PBTK NA 50% Rat Human +DTXSID1025304 Css NA 0.02093 mg/L PBTK NA 95% Rat Human +DTXSID1025431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025431 Fup 0.0739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025431 Vd NA 1.659 L/kg 1compartment NA NA Human Human DTXSID1025431 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025431 TK.Half.Life NA 8.242 hours 1compartment NA NA Human Human -DTXSID1025431 Css NA 0.6894 mg/L 3compartmentss NA 50% Human Human -DTXSID1025431 Css NA 4.63 mg/L 3compartmentss NA 95% Human Human -DTXSID1025431 Css NA 0.4549 mg/L PBTK NA 50% Human Human -DTXSID1025431 Css NA 2.898 mg/L PBTK NA 95% Human Human -DTXSID1025431 Clint NA 14.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025431 Fup NA 0.072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025431 Vd NA 1.227 L/kg 1compartment NA NA Rat Human +DTXSID1025431 TK.Half.Life NA 6.091 hours 1compartment NA NA Human Human +DTXSID1025431 Css NA 0.4372 mg/L 3compartmentss NA 50% Human Human +DTXSID1025431 Css NA 3.161 mg/L 3compartmentss NA 95% Human Human +DTXSID1025431 Css NA 0.2882 mg/L PBTK NA 50% Human Human +DTXSID1025431 Css NA 1.999 mg/L PBTK NA 95% Human Human +DTXSID1025431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025431 Fup 0.0739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025431 Vd NA 1.254 L/kg 1compartment NA NA Rat Human DTXSID1025431 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025431 TK.Half.Life NA 3.077 hours 1compartment NA NA Rat Human -DTXSID1025431 Css NA 0.376 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025431 Css NA 1.925 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025431 Css NA 0.2315 mg/L PBTK NA 50% Rat Human -DTXSID1025431 Css NA 1.145 mg/L PBTK NA 95% Rat Human +DTXSID1025431 TK.Half.Life NA 2.248 hours 1compartment NA NA Rat Human +DTXSID1025431 Css NA 0.05648 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025431 Css NA 0.3311 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025431 Css NA 0.03617 mg/L PBTK NA 50% Rat Human +DTXSID1025431 Css NA 0.2035 mg/L PBTK NA 95% Rat Human DTXSID1025433 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1025433 Fup NA 0.7855 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1025433 Vd NA 0.6873 L/kg 1compartment NA NA Human Human DTXSID1025433 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1025433 TK.Half.Life NA 5.663 hours 1compartment NA NA Human Human -DTXSID1025433 Css NA 1.018 mg/L 3compartmentss NA 50% Human Human -DTXSID1025433 Css NA 6.129 mg/L 3compartmentss NA 95% Human Human -DTXSID1025433 Css NA 0.8259 mg/L PBTK NA 50% Human Human -DTXSID1025433 Css NA 3.907 mg/L PBTK NA 95% Human Human +DTXSID1025433 Css NA 0.8651 mg/L 3compartmentss NA 50% Human Human +DTXSID1025433 Css NA 5.372 mg/L 3compartmentss NA 95% Human Human +DTXSID1025433 Css NA 0.7012 mg/L PBTK NA 50% Human Human +DTXSID1025433 Css NA 3.431 mg/L PBTK NA 95% Human Human DTXSID1025433 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1025433 Fup NA 0.7855 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1025433 Vd NA 0.7173 L/kg 1compartment NA NA Rat Human DTXSID1025433 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1025433 TK.Half.Life NA 2.014 hours 1compartment NA NA Rat Human -DTXSID1025433 Css NA 0.2603 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025433 Css NA 1.569 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025433 Css NA 0.2045 mg/L PBTK NA 50% Rat Human -DTXSID1025433 Css NA 0.9321 mg/L PBTK NA 95% Rat Human -DTXSID1025437 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025437 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025437 Vd NA 0.9033 L/kg 1compartment NA NA Human Human +DTXSID1025433 Css NA 0.01607 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025433 Css NA 0.1267 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025433 Css NA 0.01261 mg/L PBTK NA 50% Rat Human +DTXSID1025433 Css NA 0.08119 mg/L PBTK NA 95% Rat Human +DTXSID1025437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025437 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025437 Vd NA 0.3909 L/kg 1compartment NA NA Human Human DTXSID1025437 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025437 TK.Half.Life NA 5.874 hours 1compartment NA NA Human Human -DTXSID1025437 Css NA 0.8016 mg/L 3compartmentss NA 50% Human Human -DTXSID1025437 Css NA 5.713 mg/L 3compartmentss NA 95% Human Human -DTXSID1025437 Css NA 0.6987 mg/L PBTK NA 50% Human Human -DTXSID1025437 Css NA 3.672 mg/L PBTK NA 95% Human Human -DTXSID1025437 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025437 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025437 Vd NA 0.9211 L/kg 1compartment NA NA Rat Human +DTXSID1025437 TK.Half.Life NA 6.336 hours 1compartment NA NA Human Human +DTXSID1025437 Css NA 1.031 mg/L 3compartmentss NA 50% Human Human +DTXSID1025437 Css NA 4.76 mg/L 3compartmentss NA 95% Human Human +DTXSID1025437 Css NA 0.722 mg/L PBTK NA 50% Human Human +DTXSID1025437 Css NA 2.947 mg/L PBTK NA 95% Human Human +DTXSID1025437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025437 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025437 Vd NA 0.4147 L/kg 1compartment NA NA Rat Human DTXSID1025437 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025437 TK.Half.Life NA 2.033 hours 1compartment NA NA Rat Human -DTXSID1025437 Css NA 0.2017 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025437 Css NA 1.277 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025437 Css NA 0.1725 mg/L PBTK NA 50% Rat Human -DTXSID1025437 Css NA 0.7787 mg/L PBTK NA 95% Rat Human -DTXSID1025485 Clint NA 25.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025485 Fup NA 0.0407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025485 Vd NA 1.612 L/kg 1compartment NA NA Human Human -DTXSID1025485 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025485 TK.Half.Life NA 7.803 hours 1compartment NA NA Human Human -DTXSID1025485 Css NA 0.6855 mg/L 3compartmentss NA 50% Human Human -DTXSID1025485 Css NA 5.9 mg/L 3compartmentss NA 95% Human Human -DTXSID1025485 Css NA 0.4377 mg/L PBTK NA 50% Human Human -DTXSID1025485 Css NA 3.58 mg/L PBTK NA 95% Human Human -DTXSID1025485 Clint NA 25.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025485 Fup NA 0.0407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025485 Vd NA 1.207 L/kg 1compartment NA NA Rat Human +DTXSID1025437 TK.Half.Life NA 2.292 hours 1compartment NA NA Rat Human +DTXSID1025437 Css NA 0.005493 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025437 Css NA 0.02552 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025437 Css NA 0.003684 mg/L PBTK NA 50% Rat Human +DTXSID1025437 Css NA 0.01518 mg/L PBTK NA 95% Rat Human +DTXSID1025485 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025485 Fup 0.0677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025485 Vd NA 1.353 L/kg 1compartment NA NA Human Human +DTXSID1025485 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1025485 TK.Half.Life NA 13.56 hours 1compartment NA NA Human Human +DTXSID1025485 Css NA 1.507 mg/L 3compartmentss NA 50% Human Human +DTXSID1025485 Css NA 9.373 mg/L 3compartmentss NA 95% Human Human +DTXSID1025485 Css NA 0.9772 mg/L PBTK NA 50% Human Human +DTXSID1025485 Css NA 5.717 mg/L PBTK NA 95% Human Human +DTXSID1025485 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025485 Fup 0.0677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025485 Vd NA 1.028 L/kg 1compartment NA NA Rat Human DTXSID1025485 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025485 TK.Half.Life NA 2.907 hours 1compartment NA NA Rat Human -DTXSID1025485 Css NA 0.3845 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025485 Css NA 2.529 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025485 Css NA 0.2312 mg/L PBTK NA 50% Rat Human -DTXSID1025485 Css NA 1.448 mg/L PBTK NA 95% Rat Human -DTXSID1025512 Clint NA 9.304 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025512 Fup NA 0.5663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025512 Vd NA 5.546 L/kg 1compartment NA NA Human Human +DTXSID1025485 TK.Half.Life NA 5.373 hours 1compartment NA NA Rat Human +DTXSID1025485 Css NA 0.1856 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025485 Css NA 0.8878 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025485 Css NA 0.1167 mg/L PBTK NA 50% Rat Human +DTXSID1025485 Css NA 0.5271 mg/L PBTK NA 95% Rat Human +DTXSID1025512 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025512 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025512 Vd NA 0.8269 L/kg 1compartment NA NA Human Human DTXSID1025512 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025512 TK.Half.Life NA 6.194 hours 1compartment NA NA Human Human -DTXSID1025512 Css NA 0.0502 mg/L 3compartmentss NA 50% Human Human -DTXSID1025512 Css NA 0.3761 mg/L 3compartmentss NA 95% Human Human -DTXSID1025512 Css NA 0.06226 mg/L PBTK NA 50% Human Human -DTXSID1025512 Css NA 0.3965 mg/L PBTK NA 95% Human Human -DTXSID1025512 Clint NA 9.304 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025512 Fup NA 0.5663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025512 Vd NA 5.075 L/kg 1compartment NA NA Rat Human +DTXSID1025512 TK.Half.Life NA 4.077 hours 1compartment NA NA Human Human +DTXSID1025512 Css NA 0.6135 mg/L 3compartmentss NA 50% Human Human +DTXSID1025512 Css NA 4.419 mg/L 3compartmentss NA 95% Human Human +DTXSID1025512 Css NA 0.4159 mg/L PBTK NA 50% Human Human +DTXSID1025512 Css NA 2.741 mg/L PBTK NA 95% Human Human +DTXSID1025512 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025512 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025512 Vd NA 0.8169 L/kg 1compartment NA NA Rat Human DTXSID1025512 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025512 TK.Half.Life NA 1.703 hours 1compartment NA NA Rat Human -DTXSID1025512 Css NA 0.02638 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025512 Css NA 0.1633 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025512 Css NA 0.03336 mg/L PBTK NA 50% Rat Human -DTXSID1025512 Css NA 0.175 mg/L PBTK NA 95% Rat Human -DTXSID1025560 Clint NA 14.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025560 Fup NA 0.1211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025560 Vd NA 0.5236 L/kg 1compartment NA NA Human Human +DTXSID1025512 TK.Half.Life NA 2.436 hours 1compartment NA NA Rat Human +DTXSID1025512 Css NA 0.07472 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025512 Css NA 0.4097 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025512 Css NA 0.04952 mg/L PBTK NA 50% Rat Human +DTXSID1025512 Css NA 0.2441 mg/L PBTK NA 95% Rat Human +DTXSID1025560 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025560 Fup 0.157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025560 Vd NA 0.5975 L/kg 1compartment NA NA Human Human DTXSID1025560 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025560 TK.Half.Life NA 1.556 hours 1compartment NA NA Human Human -DTXSID1025560 Css NA 0.3538 mg/L 3compartmentss NA 50% Human Human -DTXSID1025560 Css NA 2.737 mg/L 3compartmentss NA 95% Human Human -DTXSID1025560 Css NA 0.2235 mg/L PBTK NA 50% Human Human -DTXSID1025560 Css NA 1.645 mg/L PBTK NA 95% Human Human -DTXSID1025560 Clint NA 14.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025560 Fup NA 0.1211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025560 Vd NA 0.447 L/kg 1compartment NA NA Rat Human +DTXSID1025560 TK.Half.Life NA 2.6 hours 1compartment NA NA Human Human +DTXSID1025560 Css NA 0.5251 mg/L 3compartmentss NA 50% Human Human +DTXSID1025560 Css NA 3.396 mg/L 3compartmentss NA 95% Human Human +DTXSID1025560 Css NA 0.3416 mg/L PBTK NA 50% Human Human +DTXSID1025560 Css NA 2.085 mg/L PBTK NA 95% Human Human +DTXSID1025560 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025560 Fup 0.157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025560 Vd NA 0.5098 L/kg 1compartment NA NA Rat Human DTXSID1025560 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025560 TK.Half.Life NA 0.7834 hours 1compartment NA NA Rat Human -DTXSID1025560 Css NA 0.1952 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025560 Css NA 1.155 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025560 Css NA 0.1165 mg/L PBTK NA 50% Rat Human -DTXSID1025560 Css NA 0.6574 mg/L PBTK NA 95% Rat Human -DTXSID1025641 Clint NA 0.9225 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025641 Fup NA 0.1094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025641 Vd NA 0.3905 L/kg 1compartment NA NA Human Human +DTXSID1025560 TK.Half.Life NA 1.297 hours 1compartment NA NA Rat Human +DTXSID1025560 Css NA 0.06355 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025560 Css NA 0.304 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025560 Css NA 0.04032 mg/L PBTK NA 50% Rat Human +DTXSID1025560 Css NA 0.1795 mg/L PBTK NA 95% Rat Human +DTXSID1025641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025641 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025641 Vd NA 0.4016 L/kg 1compartment NA NA Human Human DTXSID1025641 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025641 TK.Half.Life NA 9.263 hours 1compartment NA NA Human Human -DTXSID1025641 Css NA 3.493 mg/L 3compartmentss NA 50% Human Human -DTXSID1025641 Css NA 19.4 mg/L 3compartmentss NA 95% Human Human -DTXSID1025641 Css NA 2.267 mg/L PBTK NA 50% Human Human -DTXSID1025641 Css NA 11.42 mg/L PBTK NA 95% Human Human -DTXSID1025641 Clint NA 0.9225 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025641 Fup NA 0.1094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025641 Vd NA 0.3843 L/kg 1compartment NA NA Rat Human +DTXSID1025641 TK.Half.Life NA 0.9313 hours 1compartment NA NA Human Human +DTXSID1025641 Css NA 0.234 mg/L 3compartmentss NA 50% Human Human +DTXSID1025641 Css NA 1.971 mg/L 3compartmentss NA 95% Human Human +DTXSID1025641 Css NA 0.1518 mg/L PBTK NA 50% Human Human +DTXSID1025641 Css NA 1.203 mg/L PBTK NA 95% Human Human +DTXSID1025641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025641 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025641 Vd NA 0.3955 L/kg 1compartment NA NA Rat Human DTXSID1025641 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025641 TK.Half.Life NA 4.475 hours 1compartment NA NA Rat Human -DTXSID1025641 Css NA 1.444 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025641 Css NA 6.275 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025641 Css NA 0.8798 mg/L PBTK NA 50% Rat Human -DTXSID1025641 Css NA 3.507 mg/L PBTK NA 95% Rat Human -DTXSID1025693 Clint NA 421.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025693 Fup NA 0.2629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025693 Vd NA 1.204 L/kg 1compartment NA NA Human Human +DTXSID1025641 TK.Half.Life NA 0.5398 hours 1compartment NA NA Rat Human +DTXSID1025641 Css NA 0.03039 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025641 Css NA 0.1976 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025641 Css NA 0.01925 mg/L PBTK NA 50% Rat Human +DTXSID1025641 Css NA 0.1183 mg/L PBTK NA 95% Rat Human +DTXSID1025693 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025693 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025693 Vd NA 1.158 L/kg 1compartment NA NA Human Human DTXSID1025693 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025693 TK.Half.Life NA 0.9442 hours 1compartment NA NA Human Human -DTXSID1025693 Css NA 0.004636 mg/L 3compartmentss NA 50% Human Human -DTXSID1025693 Css NA 0.03563 mg/L 3compartmentss NA 95% Human Human -DTXSID1025693 Css NA 0.003404 mg/L PBTK NA 50% Human Human -DTXSID1025693 Css NA 0.02415 mg/L PBTK NA 95% Human Human -DTXSID1025693 Clint NA 421.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025693 Fup NA 0.2629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025693 Vd NA 0.9915 L/kg 1compartment NA NA Rat Human +DTXSID1025693 TK.Half.Life NA 1.485 hours 1compartment NA NA Human Human +DTXSID1025693 Css NA 0.06619 mg/L 3compartmentss NA 50% Human Human +DTXSID1025693 Css NA 0.5146 mg/L 3compartmentss NA 95% Human Human +DTXSID1025693 Css NA 0.04948 mg/L PBTK NA 50% Human Human +DTXSID1025693 Css NA 0.3516 mg/L PBTK NA 95% Human Human +DTXSID1025693 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025693 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025693 Vd NA 0.9759 L/kg 1compartment NA NA Rat Human DTXSID1025693 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025693 TK.Half.Life NA 0.3437 hours 1compartment NA NA Rat Human -DTXSID1025693 Css NA 0.002577 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025693 Css NA 0.01619 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025693 Css NA 0.00182 mg/L PBTK NA 50% Rat Human -DTXSID1025693 Css NA 0.01053 mg/L PBTK NA 95% Rat Human -DTXSID1025722 Clint NA 0.2408 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025722 Fup NA 0.4797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025722 Vd NA 1.001 L/kg 1compartment NA NA Human Human -DTXSID1025722 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1025722 TK.Half.Life NA 10.28 hours 1compartment NA NA Human Human -DTXSID1025722 Css NA 1.054 mg/L 3compartmentss NA 50% Human Human -DTXSID1025722 Css NA 5.271 mg/L 3compartmentss NA 95% Human Human -DTXSID1025722 Css NA 0.8454 mg/L PBTK NA 50% Human Human -DTXSID1025722 Css NA 3.432 mg/L PBTK NA 95% Human Human -DTXSID1025722 Clint NA 0.2408 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025722 Fup NA 0.4797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025722 Vd NA 0.893 L/kg 1compartment NA NA Rat Human +DTXSID1025693 TK.Half.Life NA 0.6377 hours 1compartment NA NA Rat Human +DTXSID1025693 Css NA 0.008245 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025693 Css NA 0.04868 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025693 Css NA 0.006216 mg/L PBTK NA 50% Rat Human +DTXSID1025693 Css NA 0.03333 mg/L PBTK NA 95% Rat Human +DTXSID1025722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025722 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025722 Vd NA 0.6634 L/kg 1compartment NA NA Human Human +DTXSID1025722 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1025722 TK.Half.Life NA 1.013 hours 1compartment NA NA Human Human +DTXSID1025722 Css NA 0.09388 mg/L 3compartmentss NA 50% Human Human +DTXSID1025722 Css NA 0.6583 mg/L 3compartmentss NA 95% Human Human +DTXSID1025722 Css NA 0.06443 mg/L PBTK NA 50% Human Human +DTXSID1025722 Css NA 0.426 mg/L PBTK NA 95% Human Human +DTXSID1025722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025722 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025722 Vd NA 0.5886 L/kg 1compartment NA NA Rat Human DTXSID1025722 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025722 TK.Half.Life NA 3.485 hours 1compartment NA NA Rat Human -DTXSID1025722 Css NA 0.3414 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025722 Css NA 1.515 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025722 Css NA 0.2616 mg/L PBTK NA 50% Rat Human -DTXSID1025722 Css NA 0.9163 mg/L PBTK NA 95% Rat Human -DTXSID1025724 Clint NA 3.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025724 Fup NA 0.4424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025724 Vd NA 1.057 L/kg 1compartment NA NA Human Human +DTXSID1025722 TK.Half.Life NA 0.4854 hours 1compartment NA NA Rat Human +DTXSID1025722 Css NA 0.01176 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025722 Css NA 0.063 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025722 Css NA 0.008012 mg/L PBTK NA 50% Rat Human +DTXSID1025722 Css NA 0.04014 mg/L PBTK NA 95% Rat Human +DTXSID1025724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025724 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025724 Vd NA 0.7403 L/kg 1compartment NA NA Human Human DTXSID1025724 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025724 TK.Half.Life NA 2.941 hours 1compartment NA NA Human Human -DTXSID1025724 Css NA 0.2551 mg/L 3compartmentss NA 50% Human Human -DTXSID1025724 Css NA 1.591 mg/L 3compartmentss NA 95% Human Human -DTXSID1025724 Css NA 0.2016 mg/L PBTK NA 50% Human Human -DTXSID1025724 Css NA 1.085 mg/L PBTK NA 95% Human Human -DTXSID1025724 Clint NA 3.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025724 Fup NA 0.4424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025724 Vd NA 0.9269 L/kg 1compartment NA NA Rat Human +DTXSID1025724 TK.Half.Life NA 1.118 hours 1compartment NA NA Human Human +DTXSID1025724 Css NA 0.09004 mg/L 3compartmentss NA 50% Human Human +DTXSID1025724 Css NA 0.6799 mg/L 3compartmentss NA 95% Human Human +DTXSID1025724 Css NA 0.06261 mg/L PBTK NA 50% Human Human +DTXSID1025724 Css NA 0.4382 mg/L PBTK NA 95% Human Human +DTXSID1025724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025724 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025724 Vd NA 0.6459 L/kg 1compartment NA NA Rat Human DTXSID1025724 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025724 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Human -DTXSID1025724 Css NA 0.1206 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025724 Css NA 0.5964 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025724 Css NA 0.09188 mg/L PBTK NA 50% Rat Human -DTXSID1025724 Css NA 0.3689 mg/L PBTK NA 95% Rat Human -DTXSID1025726 Clint NA 1.419 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025726 Fup NA 0.618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025726 Vd NA 1.756 L/kg 1compartment NA NA Human Human +DTXSID1025724 TK.Half.Life NA 0.5235 hours 1compartment NA NA Rat Human +DTXSID1025724 Css NA 0.01153 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025724 Css NA 0.06191 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025724 Css NA 0.007911 mg/L PBTK NA 50% Rat Human +DTXSID1025724 Css NA 0.03941 mg/L PBTK NA 95% Rat Human +DTXSID1025726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025726 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025726 Vd NA 1.006 L/kg 1compartment NA NA Human Human DTXSID1025726 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025726 TK.Half.Life NA 7.485 hours 1compartment NA NA Human Human -DTXSID1025726 Css NA 0.4047 mg/L 3compartmentss NA 50% Human Human -DTXSID1025726 Css NA 2.763 mg/L 3compartmentss NA 95% Human Human -DTXSID1025726 Css NA 0.3551 mg/L PBTK NA 50% Human Human -DTXSID1025726 Css NA 1.917 mg/L PBTK NA 95% Human Human -DTXSID1025726 Clint NA 1.419 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025726 Fup NA 0.618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025726 Vd NA 1.475 L/kg 1compartment NA NA Rat Human +DTXSID1025726 TK.Half.Life NA 1.616 hours 1compartment NA NA Human Human +DTXSID1025726 Css NA 0.101 mg/L 3compartmentss NA 50% Human Human +DTXSID1025726 Css NA 0.7227 mg/L 3compartmentss NA 95% Human Human +DTXSID1025726 Css NA 0.07172 mg/L PBTK NA 50% Human Human +DTXSID1025726 Css NA 0.4753 mg/L PBTK NA 95% Human Human +DTXSID1025726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025726 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025726 Vd NA 0.835 L/kg 1compartment NA NA Rat Human DTXSID1025726 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025726 TK.Half.Life NA 2.679 hours 1compartment NA NA Rat Human -DTXSID1025726 Css NA 0.17 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025726 Css NA 1.029 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025726 Css NA 0.1461 mg/L PBTK NA 50% Rat Human -DTXSID1025726 Css NA 0.6375 mg/L PBTK NA 95% Rat Human -DTXSID1025770 Clint NA 38.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025770 Fup NA 0.7827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025770 Vd NA 1.065 L/kg 1compartment NA NA Human Human +DTXSID1025726 TK.Half.Life NA 0.7114 hours 1compartment NA NA Rat Human +DTXSID1025726 Css NA 0.01289 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025726 Css NA 0.06977 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025726 Css NA 0.008987 mg/L PBTK NA 50% Rat Human +DTXSID1025726 Css NA 0.04631 mg/L PBTK NA 95% Rat Human +DTXSID1025770 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025770 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025770 Vd NA 0.7012 L/kg 1compartment NA NA Human Human DTXSID1025770 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025770 TK.Half.Life NA 0.723 hours 1compartment NA NA Human Human -DTXSID1025770 Css NA 0.0156 mg/L 3compartmentss NA 50% Human Human -DTXSID1025770 Css NA 0.1669 mg/L 3compartmentss NA 95% Human Human -DTXSID1025770 Css NA 0.01352 mg/L PBTK NA 50% Human Human -DTXSID1025770 Css NA 0.1213 mg/L PBTK NA 95% Human Human -DTXSID1025770 Clint NA 38.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025770 Fup NA 0.7827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025770 Vd NA 1.02 L/kg 1compartment NA NA Rat Human +DTXSID1025770 TK.Half.Life NA 0.806 hours 1compartment NA NA Human Human +DTXSID1025770 Css NA 0.05066 mg/L 3compartmentss NA 50% Human Human +DTXSID1025770 Css NA 0.4219 mg/L 3compartmentss NA 95% Human Human +DTXSID1025770 Css NA 0.03788 mg/L PBTK NA 50% Human Human +DTXSID1025770 Css NA 0.2863 mg/L PBTK NA 95% Human Human +DTXSID1025770 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025770 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025770 Vd NA 0.6663 L/kg 1compartment NA NA Rat Human DTXSID1025770 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025770 TK.Half.Life NA 0.3227 hours 1compartment NA NA Rat Human -DTXSID1025770 Css NA 0.008134 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025770 Css NA 0.07403 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025770 Css NA 0.006906 mg/L PBTK NA 50% Rat Human -DTXSID1025770 Css NA 0.05181 mg/L PBTK NA 95% Rat Human -DTXSID1025774 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025774 Fup NA 0.271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025774 Vd NA 0.3581 L/kg 1compartment NA NA Human Human +DTXSID1025770 TK.Half.Life NA 0.3959 hours 1compartment NA NA Rat Human +DTXSID1025770 Css NA 0.00638 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025770 Css NA 0.03823 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025770 Css NA 0.004727 mg/L PBTK NA 50% Rat Human +DTXSID1025770 Css NA 0.02524 mg/L PBTK NA 95% Rat Human +DTXSID1025774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025774 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025774 Vd NA 0.3159 L/kg 1compartment NA NA Human Human DTXSID1025774 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025774 TK.Half.Life NA 8.559 hours 1compartment NA NA Human Human -DTXSID1025774 Css NA 2.965 mg/L 3compartmentss NA 50% Human Human -DTXSID1025774 Css NA 11.07 mg/L 3compartmentss NA 95% Human Human -DTXSID1025774 Css NA 1.95 mg/L PBTK NA 50% Human Human -DTXSID1025774 Css NA 6.758 mg/L PBTK NA 95% Human Human -DTXSID1025774 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025774 Fup NA 0.271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025774 Vd NA 0.3588 L/kg 1compartment NA NA Rat Human +DTXSID1025774 TK.Half.Life NA 0.5348 hours 1compartment NA NA Human Human +DTXSID1025774 Css NA 0.1126 mg/L 3compartmentss NA 50% Human Human +DTXSID1025774 Css NA 0.7883 mg/L 3compartmentss NA 95% Human Human +DTXSID1025774 Css NA 0.07219 mg/L PBTK NA 50% Human Human +DTXSID1025774 Css NA 0.4801 mg/L PBTK NA 95% Human Human +DTXSID1025774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025774 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025774 Vd NA 0.3155 L/kg 1compartment NA NA Rat Human DTXSID1025774 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025774 TK.Half.Life NA 2.92 hours 1compartment NA NA Rat Human -DTXSID1025774 Css NA 0.8263 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025774 Css NA 2.617 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025774 Css NA 0.5156 mg/L PBTK NA 50% Rat Human -DTXSID1025774 Css NA 1.49 mg/L PBTK NA 95% Rat Human -DTXSID1025776 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025776 Fup NA 0.2521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025776 Vd NA 0.5031 L/kg 1compartment NA NA Human Human -DTXSID1025776 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1025776 TK.Half.Life NA 13 hours 1compartment NA NA Human Human -DTXSID1025776 Css NA 3.063 mg/L 3compartmentss NA 50% Human Human -DTXSID1025776 Css NA 11.62 mg/L 3compartmentss NA 95% Human Human -DTXSID1025776 Css NA 2.12 mg/L PBTK NA 50% Human Human -DTXSID1025776 Css NA 7.184 mg/L PBTK NA 95% Human Human -DTXSID1025776 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025776 Fup NA 0.2521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025776 Vd NA 0.4869 L/kg 1compartment NA NA Rat Human +DTXSID1025774 TK.Half.Life NA 0.294 hours 1compartment NA NA Rat Human +DTXSID1025774 Css NA 0.01437 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025774 Css NA 0.07648 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025774 Css NA 0.008976 mg/L PBTK NA 50% Rat Human +DTXSID1025774 Css NA 0.04609 mg/L PBTK NA 95% Rat Human +DTXSID1025776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025776 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025776 Vd NA 0.4342 L/kg 1compartment NA NA Human Human +DTXSID1025776 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1025776 TK.Half.Life NA 0.7489 hours 1compartment NA NA Human Human +DTXSID1025776 Css NA 0.1161 mg/L 3compartmentss NA 50% Human Human +DTXSID1025776 Css NA 0.8277 mg/L 3compartmentss NA 95% Human Human +DTXSID1025776 Css NA 0.07636 mg/L PBTK NA 50% Human Human +DTXSID1025776 Css NA 0.5208 mg/L PBTK NA 95% Human Human +DTXSID1025776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025776 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025776 Vd NA 0.4196 L/kg 1compartment NA NA Rat Human DTXSID1025776 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025776 TK.Half.Life NA 4.266 hours 1compartment NA NA Rat Human -DTXSID1025776 Css NA 0.8482 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025776 Css NA 2.691 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025776 Css NA 0.5529 mg/L PBTK NA 50% Rat Human -DTXSID1025776 Css NA 1.56 mg/L PBTK NA 95% Rat Human -DTXSID1025807 Clint NA 13.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025807 Fup NA 0.0075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025807 Vd NA 0.221 L/kg 1compartment NA NA Human Human +DTXSID1025776 TK.Half.Life NA 0.4023 hours 1compartment NA NA Rat Human +DTXSID1025776 Css NA 0.01492 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025776 Css NA 0.07873 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025776 Css NA 0.009648 mg/L PBTK NA 50% Rat Human +DTXSID1025776 Css NA 0.04805 mg/L PBTK NA 95% Rat Human +DTXSID1025805 Clint 12.72 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID1025805 Fup 0.02822 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID1025805 Vd NA 0.6125 L/kg 1compartment NA NA Human Human +DTXSID1025805 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1025805 TK.Half.Life NA 6.508 hours 1compartment NA NA Human Human +DTXSID1025805 Css NA 1.79 mg/L 3compartmentss NA 50% Human Human +DTXSID1025805 Css NA 15.46 mg/L 3compartmentss NA 95% Human Human +DTXSID1025805 Css NA 1.076 mg/L PBTK NA 50% Human Human +DTXSID1025805 Css NA 9.176 mg/L PBTK NA 95% Human Human +DTXSID1025805 Clint 12.72 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID1025805 Fup 0.02822 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID1025805 Vd NA 0.4754 L/kg 1compartment NA NA Rat Human +DTXSID1025805 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1025805 TK.Half.Life NA 3.159 hours 1compartment NA NA Rat Human +DTXSID1025805 Css NA 0.2304 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025805 Css NA 1.676 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025805 Css NA 0.1342 mg/L PBTK NA 50% Rat Human +DTXSID1025805 Css NA 0.9517 mg/L PBTK NA 95% Rat Human +DTXSID1025807 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025807 Fup 0.048 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025807 Vd NA 0.4779 L/kg 1compartment NA NA Human Human DTXSID1025807 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025807 TK.Half.Life NA 8.37 hours 1compartment NA NA Human Human -DTXSID1025807 Css NA 7.02 mg/L 3compartmentss NA 50% Human Human -DTXSID1025807 Css NA 67.96 mg/L 3compartmentss NA 95% Human Human -DTXSID1025807 Css NA 4.131 mg/L PBTK NA 50% Human Human -DTXSID1025807 Css NA 40.04 mg/L PBTK NA 95% Human Human -DTXSID1025807 Clint NA 13.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025807 Fup NA 0.0075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025807 Vd NA 0.2082 L/kg 1compartment NA NA Rat Human +DTXSID1025807 TK.Half.Life NA 2.091 hours 1compartment NA NA Human Human +DTXSID1025807 Css NA 0.601 mg/L 3compartmentss NA 50% Human Human +DTXSID1025807 Css NA 5.131 mg/L 3compartmentss NA 95% Human Human +DTXSID1025807 Css NA 0.3875 mg/L PBTK NA 50% Human Human +DTXSID1025807 Css NA 3.215 mg/L PBTK NA 95% Human Human +DTXSID1025807 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025807 Fup 0.048 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025807 Vd NA 0.4373 L/kg 1compartment NA NA Rat Human DTXSID1025807 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025807 TK.Half.Life NA 5.239 hours 1compartment NA NA Rat Human -DTXSID1025807 Css NA 3.984 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025807 Css NA 28.85 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025807 Css NA 2.19 mg/L PBTK NA 50% Rat Human -DTXSID1025807 Css NA 15.6 mg/L PBTK NA 95% Rat Human -DTXSID1025809 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025809 Fup NA 0.0073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025809 Vd NA 19.74 L/kg 1compartment NA NA Human Human -DTXSID1025809 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID1025809 TK.Half.Life NA 25130 hours 1compartment NA NA Human Human -DTXSID1025809 Css NA 66.43 mg/L 3compartmentss NA 50% Human Human -DTXSID1025809 Css NA 637.8 mg/L 3compartmentss NA 95% Human Human -DTXSID1025809 Css NA 124.6 mg/L PBTK NA 50% Human Human -DTXSID1025809 Css NA 603.7 mg/L PBTK NA 95% Human Human -DTXSID1025809 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025809 Fup NA 0.0073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025809 Vd NA 16.04 L/kg 1compartment NA NA Rat Human -DTXSID1025809 Days.Css NA 1916 Days PBTK NA NA Rat Human -DTXSID1025809 TK.Half.Life NA 5348 hours 1compartment NA NA Rat Human -DTXSID1025809 Css NA 16.84 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025809 Css NA 155.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025809 Css NA 32.6 mg/L PBTK NA 50% Rat Human -DTXSID1025809 Css NA 135.8 mg/L PBTK NA 95% Rat Human +DTXSID1025807 TK.Half.Life NA 1.202 hours 1compartment NA NA Rat Human +DTXSID1025807 Css NA 0.07776 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025807 Css NA 0.5357 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025807 Css NA 0.04878 mg/L PBTK NA 50% Rat Human +DTXSID1025807 Css NA 0.3141 mg/L PBTK NA 95% Rat Human DTXSID1025853 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1025853 Fup NA 0.5619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025853 Vd NA 0.4215 L/kg 1compartment NA NA Human Human +DTXSID1025853 Vd NA 0.4359 L/kg 1compartment NA NA Human Human DTXSID1025853 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025853 TK.Half.Life NA 4.854 hours 1compartment NA NA Human Human -DTXSID1025853 Css NA 1.465 mg/L 3compartmentss NA 50% Human Human -DTXSID1025853 Css NA 9.151 mg/L 3compartmentss NA 95% Human Human -DTXSID1025853 Css NA 1.042 mg/L PBTK NA 50% Human Human -DTXSID1025853 Css NA 5.615 mg/L PBTK NA 95% Human Human +DTXSID1025853 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human +DTXSID1025853 Css NA 1.206 mg/L 3compartmentss NA 50% Human Human +DTXSID1025853 Css NA 7.766 mg/L 3compartmentss NA 95% Human Human +DTXSID1025853 Css NA 0.8706 mg/L PBTK NA 50% Human Human +DTXSID1025853 Css NA 4.731 mg/L PBTK NA 95% Human Human DTXSID1025853 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1025853 Fup NA 0.5619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025853 Vd NA 0.4393 L/kg 1compartment NA NA Rat Human +DTXSID1025853 Vd NA 0.4516 L/kg 1compartment NA NA Rat Human DTXSID1025853 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025853 TK.Half.Life NA 1.724 hours 1compartment NA NA Rat Human -DTXSID1025853 Css NA 0.3846 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025853 Css NA 2.321 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025853 Css NA 0.2612 mg/L PBTK NA 50% Rat Human -DTXSID1025853 Css NA 1.317 mg/L PBTK NA 95% Rat Human -DTXSID1025930 Clint NA 0.2641 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025930 Fup NA 0.0683 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025930 Vd NA 0.3635 L/kg 1compartment NA NA Human Human -DTXSID1025930 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1025930 TK.Half.Life NA 23.99 hours 1compartment NA NA Human Human -DTXSID1025930 Css NA 9.243 mg/L 3compartmentss NA 50% Human Human -DTXSID1025930 Css NA 36.58 mg/L 3compartmentss NA 95% Human Human -DTXSID1025930 Css NA 5.866 mg/L PBTK NA 50% Human Human -DTXSID1025930 Css NA 21.9 mg/L PBTK NA 95% Human Human -DTXSID1025930 Clint NA 0.2641 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025930 Fup NA 0.0683 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025930 Vd NA 0.3538 L/kg 1compartment NA NA Rat Human +DTXSID1025853 TK.Half.Life NA 1.772 hours 1compartment NA NA Rat Human +DTXSID1025853 Css NA 0.0233 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025853 Css NA 0.1937 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025853 Css NA 0.01601 mg/L PBTK NA 50% Rat Human +DTXSID1025853 Css NA 0.1154 mg/L PBTK NA 95% Rat Human +DTXSID1025857 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025857 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025857 Vd NA 0.9791 L/kg 1compartment NA NA Human Human +DTXSID1025857 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1025857 TK.Half.Life NA 3.284 hours 1compartment NA NA Human Human +DTXSID1025857 Css NA 0.3199 mg/L 3compartmentss NA 50% Human Human +DTXSID1025857 Css NA 1.895 mg/L 3compartmentss NA 95% Human Human +DTXSID1025857 Css NA 0.2272 mg/L PBTK NA 50% Human Human +DTXSID1025857 Css NA 1.25 mg/L PBTK NA 95% Human Human +DTXSID1025857 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025857 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025857 Vd NA 0.8198 L/kg 1compartment NA NA Rat Human +DTXSID1025857 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1025857 TK.Half.Life NA 1.525 hours 1compartment NA NA Rat Human +DTXSID1025857 Css NA 0.03834 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025857 Css NA 0.1708 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025857 Css NA 0.02686 mg/L PBTK NA 50% Rat Human +DTXSID1025857 Css NA 0.1084 mg/L PBTK NA 95% Rat Human +DTXSID1025930 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025930 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1025930 Vd NA 2.048 L/kg 1compartment NA NA Human Human +DTXSID1025930 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1025930 TK.Half.Life NA 5.94 hours 1compartment NA NA Human Human +DTXSID1025930 Css NA 0.2925 mg/L 3compartmentss NA 50% Human Human +DTXSID1025930 Css NA 2.147 mg/L 3compartmentss NA 95% Human Human +DTXSID1025930 Css NA 0.2024 mg/L PBTK NA 50% Human Human +DTXSID1025930 Css NA 1.369 mg/L PBTK NA 95% Human Human +DTXSID1025930 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025930 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1025930 Vd NA 1.557 L/kg 1compartment NA NA Rat Human DTXSID1025930 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025930 TK.Half.Life NA 9.425 hours 1compartment NA NA Rat Human -DTXSID1025930 Css NA 3.213 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025930 Css NA 10.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025930 Css NA 1.918 mg/L PBTK NA 50% Rat Human -DTXSID1025930 Css NA 5.958 mg/L PBTK NA 95% Rat Human -DTXSID1025934 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025934 Fup NA 0.815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1025934 Vd NA 1.023 L/kg 1compartment NA NA Human Human -DTXSID1025934 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1025934 TK.Half.Life NA 8.327 hours 1compartment NA NA Human Human -DTXSID1025934 Css NA 0.927 mg/L 3compartmentss NA 50% Human Human -DTXSID1025934 Css NA 5.825 mg/L 3compartmentss NA 95% Human Human -DTXSID1025934 Css NA 0.8149 mg/L PBTK NA 50% Human Human -DTXSID1025934 Css NA 3.882 mg/L PBTK NA 95% Human Human -DTXSID1025934 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025934 Fup NA 0.815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1025934 Vd NA 0.994 L/kg 1compartment NA NA Rat Human -DTXSID1025934 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1025934 TK.Half.Life NA 2.705 hours 1compartment NA NA Rat Human -DTXSID1025934 Css NA 0.239 mg/L 3compartmentss NA 50% Rat Human -DTXSID1025934 Css NA 1.481 mg/L 3compartmentss NA 95% Rat Human -DTXSID1025934 Css NA 0.2036 mg/L PBTK NA 50% Rat Human -DTXSID1025934 Css NA 0.9041 mg/L PBTK NA 95% Rat Human -DTXSID1026031 Clint NA 0.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026031 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026031 Vd NA 0.3401 L/kg 1compartment NA NA Human Human -DTXSID1026031 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1026031 TK.Half.Life NA 29.99 hours 1compartment NA NA Human Human -DTXSID1026031 Css NA 15.64 mg/L 3compartmentss NA 50% Human Human -DTXSID1026031 Css NA 74.8 mg/L 3compartmentss NA 95% Human Human -DTXSID1026031 Css NA 9.401 mg/L PBTK NA 50% Human Human -DTXSID1026031 Css NA 43.05 mg/L PBTK NA 95% Human Human -DTXSID1026031 Clint NA 0.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026031 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026031 Vd NA 0.2931 L/kg 1compartment NA NA Rat Human -DTXSID1026031 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1026031 TK.Half.Life NA 11.89 hours 1compartment NA NA Rat Human -DTXSID1026031 Css NA 6.076 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026031 Css NA 25.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026031 Css NA 3.407 mg/L PBTK NA 50% Rat Human -DTXSID1026031 Css NA 13.73 mg/L PBTK NA 95% Rat Human -DTXSID1026033 Clint NA 4.204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026033 Fup NA 0.1981 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026033 Vd NA 0.3161 L/kg 1compartment NA NA Human Human +DTXSID1025930 TK.Half.Life NA 1.953 hours 1compartment NA NA Rat Human +DTXSID1025930 Css NA 0.03842 mg/L 3compartmentss NA 50% Rat Human +DTXSID1025930 Css NA 0.2077 mg/L 3compartmentss NA 95% Rat Human +DTXSID1025930 Css NA 0.02604 mg/L PBTK NA 50% Rat Human +DTXSID1025930 Css NA 0.1354 mg/L PBTK NA 95% Rat Human +DTXSID1026031 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026031 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026031 Vd NA 0.7215 L/kg 1compartment NA NA Human Human +DTXSID1026031 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1026031 TK.Half.Life NA 1.394 hours 1compartment NA NA Human Human +DTXSID1026031 Css NA 0.1606 mg/L 3compartmentss NA 50% Human Human +DTXSID1026031 Css NA 1.301 mg/L 3compartmentss NA 95% Human Human +DTXSID1026031 Css NA 0.1064 mg/L PBTK NA 50% Human Human +DTXSID1026031 Css NA 0.8212 mg/L PBTK NA 95% Human Human +DTXSID1026031 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026031 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026031 Vd NA 0.6255 L/kg 1compartment NA NA Rat Human +DTXSID1026031 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1026031 TK.Half.Life NA 0.6762 hours 1compartment NA NA Rat Human +DTXSID1026031 Css NA 0.02085 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026031 Css NA 0.1266 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026031 Css NA 0.01356 mg/L PBTK NA 50% Rat Human +DTXSID1026031 Css NA 0.07741 mg/L PBTK NA 95% Rat Human +DTXSID1026033 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026033 Fup 0.541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026033 Vd NA 0.6386 L/kg 1compartment NA NA Human Human DTXSID1026033 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026033 TK.Half.Life NA 1.507 hours 1compartment NA NA Human Human -DTXSID1026033 Css NA 0.539 mg/L 3compartmentss NA 50% Human Human -DTXSID1026033 Css NA 2.845 mg/L 3compartmentss NA 95% Human Human -DTXSID1026033 Css NA 0.3494 mg/L PBTK NA 50% Human Human -DTXSID1026033 Css NA 1.74 mg/L PBTK NA 95% Human Human -DTXSID1026033 Clint NA 4.204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026033 Fup NA 0.1981 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026033 Vd NA 0.3147 L/kg 1compartment NA NA Rat Human +DTXSID1026033 TK.Half.Life NA 7.654 hours 1compartment NA NA Human Human +DTXSID1026033 Css NA 1.322 mg/L 3compartmentss NA 50% Human Human +DTXSID1026033 Css NA 8.065 mg/L 3compartmentss NA 95% Human Human +DTXSID1026033 Css NA 1.028 mg/L PBTK NA 50% Human Human +DTXSID1026033 Css NA 5.128 mg/L PBTK NA 95% Human Human +DTXSID1026033 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026033 Fup 0.541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026033 Vd NA 0.6504 L/kg 1compartment NA NA Rat Human DTXSID1026033 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026033 TK.Half.Life NA 0.8711 hours 1compartment NA NA Rat Human -DTXSID1026033 Css NA 0.2716 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026033 Css NA 1.056 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026033 Css NA 0.1659 mg/L PBTK NA 50% Rat Human -DTXSID1026033 Css NA 0.6064 mg/L PBTK NA 95% Rat Human +DTXSID1026033 TK.Half.Life NA 2.652 hours 1compartment NA NA Rat Human +DTXSID1026033 Css NA 0.08182 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026033 Css NA 0.447 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026033 Css NA 0.06293 mg/L PBTK NA 50% Rat Human +DTXSID1026033 Css NA 0.2718 mg/L PBTK NA 95% Rat Human DTXSID1026035 Clint 41.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1026035 Fup 0.0368 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1026035 Vd NA 0.27 L/kg 1compartment NA NA Human Human +DTXSID1026035 Vd NA 0.4015 L/kg 1compartment NA NA Human Human DTXSID1026035 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026035 TK.Half.Life NA 0.9157 hours 1compartment NA NA Human Human -DTXSID1026035 Css NA 0.3547 mg/L 3compartmentss NA 50% Human Human -DTXSID1026035 Css NA 2.885 mg/L 3compartmentss NA 95% Human Human -DTXSID1026035 Css NA 0.2124 mg/L PBTK NA 50% Human Human -DTXSID1026035 Css NA 1.699 mg/L PBTK NA 95% Human Human +DTXSID1026035 TK.Half.Life NA 1.337 hours 1compartment NA NA Human Human +DTXSID1026035 Css NA 0.3266 mg/L 3compartmentss NA 50% Human Human +DTXSID1026035 Css NA 2.686 mg/L 3compartmentss NA 95% Human Human +DTXSID1026035 Css NA 0.1988 mg/L PBTK NA 50% Human Human +DTXSID1026035 Css NA 1.614 mg/L PBTK NA 95% Human Human DTXSID1026035 Clint 41.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1026035 Fup 0.0368 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1026035 Vd NA 0.2439 L/kg 1compartment NA NA Rat Human +DTXSID1026035 Vd NA 0.3322 L/kg 1compartment NA NA Rat Human DTXSID1026035 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026035 TK.Half.Life NA 0.51 hours 1compartment NA NA Rat Human -DTXSID1026035 Css NA 0.2008 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026035 Css NA 1.297 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026035 Css NA 0.1124 mg/L PBTK NA 50% Rat Human -DTXSID1026035 Css NA 0.7147 mg/L PBTK NA 95% Rat Human +DTXSID1026035 TK.Half.Life NA 0.6762 hours 1compartment NA NA Rat Human +DTXSID1026035 Css NA 0.04432 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026035 Css NA 0.29 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026035 Css NA 0.02611 mg/L PBTK NA 50% Rat Human +DTXSID1026035 Css NA 0.1663 mg/L PBTK NA 95% Rat Human DTXSID1026081 Clint 50.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1026081 Fup 0.00107 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1026081 Vd NA 7.695 L/kg 1compartment NA NA Human Human -DTXSID1026081 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID1026081 TK.Half.Life NA 115.5 hours 1compartment NA NA Human Human -DTXSID1026081 Css NA 1.342 mg/L 3compartmentss NA 50% Human Human -DTXSID1026081 Css NA 9.161 mg/L 3compartmentss NA 95% Human Human -DTXSID1026081 Css NA 1.315 mg/L PBTK NA 50% Human Human -DTXSID1026081 Css NA 8.207 mg/L PBTK NA 95% Human Human +DTXSID1026081 Vd NA 2.633 L/kg 1compartment NA NA Human Human +DTXSID1026081 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1026081 TK.Half.Life NA 40.85 hours 1compartment NA NA Human Human +DTXSID1026081 Css NA 1.727 mg/L 3compartmentss NA 50% Human Human +DTXSID1026081 Css NA 11.89 mg/L 3compartmentss NA 95% Human Human +DTXSID1026081 Css NA 1.143 mg/L PBTK NA 50% Human Human +DTXSID1026081 Css NA 7.807 mg/L PBTK NA 95% Human Human DTXSID1026081 Clint 50.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1026081 Fup 0.00107 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1026081 Vd NA 5.986 L/kg 1compartment NA NA Rat Human -DTXSID1026081 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID1026081 TK.Half.Life NA 24.95 hours 1compartment NA NA Rat Human -DTXSID1026081 Css NA 0.7492 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026081 Css NA 3.758 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026081 Css NA 0.7276 mg/L PBTK NA 50% Rat Human -DTXSID1026081 Css NA 3.333 mg/L PBTK NA 95% Rat Human -DTXSID1026083 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026083 Fup NA 0.3328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026083 Vd NA 2.938 L/kg 1compartment NA NA Human Human -DTXSID1026083 Days.Css NA 98 Days PBTK NA NA Human Human -DTXSID1026083 TK.Half.Life NA 422.1 hours 1compartment NA NA Human Human -DTXSID1026083 Css NA 15.75 mg/L 3compartmentss NA 50% Human Human -DTXSID1026083 Css NA 45.75 mg/L 3compartmentss NA 95% Human Human -DTXSID1026083 Css NA 11.56 mg/L PBTK NA 50% Human Human -DTXSID1026083 Css NA 30.75 mg/L PBTK NA 95% Human Human -DTXSID1026083 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026083 Fup NA 0.3328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026083 Vd NA 2.23 L/kg 1compartment NA NA Rat Human -DTXSID1026083 Days.Css NA 23 Days PBTK NA NA Rat Human -DTXSID1026083 TK.Half.Life NA 37.27 hours 1compartment NA NA Rat Human -DTXSID1026083 Css NA 4.231 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026083 Css NA 9.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026083 Css NA 2.992 mg/L PBTK NA 50% Rat Human -DTXSID1026083 Css NA 6.13 mg/L PBTK NA 95% Rat Human -DTXSID1026112 Clint NA 17.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026112 Fup NA 0.3592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026112 Vd NA 3.23 L/kg 1compartment NA NA Human Human +DTXSID1026081 Vd NA 1.96 L/kg 1compartment NA NA Rat Human +DTXSID1026081 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID1026081 TK.Half.Life NA 28.55 hours 1compartment NA NA Rat Human +DTXSID1026081 Css NA 0.2158 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026081 Css NA 1.605 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026081 Css NA 0.1378 mg/L PBTK NA 50% Rat Human +DTXSID1026081 Css NA 1.001 mg/L PBTK NA 95% Rat Human +DTXSID1026112 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026112 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026112 Vd NA 2.73 L/kg 1compartment NA NA Human Human DTXSID1026112 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026112 TK.Half.Life NA 3.002 hours 1compartment NA NA Human Human -DTXSID1026112 Css NA 0.03816 mg/L 3compartmentss NA 50% Human Human -DTXSID1026112 Css NA 0.3438 mg/L 3compartmentss NA 95% Human Human -DTXSID1026112 Css NA 0.04684 mg/L PBTK NA 50% Human Human -DTXSID1026112 Css NA 0.326 mg/L PBTK NA 95% Human Human -DTXSID1026112 Clint NA 17.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026112 Fup NA 0.3592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026112 Vd NA 3.235 L/kg 1compartment NA NA Rat Human +DTXSID1026112 TK.Half.Life NA 4.606 hours 1compartment NA NA Human Human +DTXSID1026112 Css NA 0.1011 mg/L 3compartmentss NA 50% Human Human +DTXSID1026112 Css NA 0.8023 mg/L 3compartmentss NA 95% Human Human +DTXSID1026112 Css NA 0.1077 mg/L PBTK NA 50% Human Human +DTXSID1026112 Css NA 0.657 mg/L PBTK NA 95% Human Human +DTXSID1026112 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026112 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026112 Vd NA 2.767 L/kg 1compartment NA NA Rat Human DTXSID1026112 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026112 TK.Half.Life NA 1.69 hours 1compartment NA NA Rat Human -DTXSID1026112 Css NA 0.01971 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026112 Css NA 0.1347 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026112 Css NA 0.02414 mg/L PBTK NA 50% Rat Human -DTXSID1026112 Css NA 0.1245 mg/L PBTK NA 95% Rat Human +DTXSID1026112 TK.Half.Life NA 2.686 hours 1compartment NA NA Rat Human +DTXSID1026112 Css NA 0.01147 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026112 Css NA 0.07446 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026112 Css NA 0.01284 mg/L PBTK NA 50% Rat Human +DTXSID1026112 Css NA 0.05814 mg/L PBTK NA 95% Rat Human DTXSID1026164 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1026164 Fup 0.713 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1026164 Vd NA 1.344 L/kg 1compartment NA NA Human Human DTXSID1026164 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1026164 TK.Half.Life NA 13.52 hours 1compartment NA NA Human Human -DTXSID1026164 Css NA 0.9658 mg/L 3compartmentss NA 50% Human Human -DTXSID1026164 Css NA 3.332 mg/L 3compartmentss NA 95% Human Human -DTXSID1026164 Css NA 0.8711 mg/L PBTK NA 50% Human Human -DTXSID1026164 Css NA 2.479 mg/L PBTK NA 95% Human Human +DTXSID1026164 Css NA 0.936 mg/L 3compartmentss NA 50% Human Human +DTXSID1026164 Css NA 3.224 mg/L 3compartmentss NA 95% Human Human +DTXSID1026164 Css NA 0.8468 mg/L PBTK NA 50% Human Human +DTXSID1026164 Css NA 2.404 mg/L PBTK NA 95% Human Human DTXSID1026164 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1026164 Fup 0.713 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1026164 Vd NA 1.209 L/kg 1compartment NA NA Rat Human DTXSID1026164 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1026164 TK.Half.Life NA 3.836 hours 1compartment NA NA Rat Human -DTXSID1026164 Css NA 0.2534 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026164 Css NA 0.7988 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026164 Css NA 0.2244 mg/L PBTK NA 50% Rat Human -DTXSID1026164 Css NA 0.5451 mg/L PBTK NA 95% Rat Human -DTXSID1026241 Clint NA 45.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026241 Fup NA 0.0186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026241 Vd NA 2.439 L/kg 1compartment NA NA Human Human +DTXSID1026164 Css NA 0.05665 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026164 Css NA 0.1783 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026164 Css NA 0.0521 mg/L PBTK NA 50% Rat Human +DTXSID1026164 Css NA 0.1263 mg/L PBTK NA 95% Rat Human +DTXSID1026241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026241 Fup 0.0337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026241 Vd NA 2.196 L/kg 1compartment NA NA Human Human DTXSID1026241 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1026241 TK.Half.Life NA 15.79 hours 1compartment NA NA Human Human -DTXSID1026241 Css NA 0.8708 mg/L 3compartmentss NA 50% Human Human -DTXSID1026241 Css NA 6.669 mg/L 3compartmentss NA 95% Human Human -DTXSID1026241 Css NA 0.5754 mg/L PBTK NA 50% Human Human -DTXSID1026241 Css NA 4.169 mg/L PBTK NA 95% Human Human -DTXSID1026241 Clint NA 45.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026241 Fup NA 0.0186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026241 Vd NA 1.818 L/kg 1compartment NA NA Rat Human +DTXSID1026241 TK.Half.Life NA 17.01 hours 1compartment NA NA Human Human +DTXSID1026241 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human +DTXSID1026241 Css NA 7.531 mg/L 3compartmentss NA 95% Human Human +DTXSID1026241 Css NA 0.6914 mg/L PBTK NA 50% Human Human +DTXSID1026241 Css NA 4.771 mg/L PBTK NA 95% Human Human +DTXSID1026241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026241 Fup 0.0337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026241 Vd NA 1.64 L/kg 1compartment NA NA Rat Human DTXSID1026241 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026241 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human -DTXSID1026241 Css NA 0.4854 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026241 Css NA 3.188 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026241 Css NA 0.303 mg/L PBTK NA 50% Rat Human -DTXSID1026241 Css NA 1.909 mg/L PBTK NA 95% Rat Human -DTXSID1026293 Clint NA 2.101 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026293 Fup NA 0.0111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026293 Vd NA 1.502 L/kg 1compartment NA NA Human Human -DTXSID1026293 Days.Css NA 37 Days PBTK NA NA Human Human -DTXSID1026293 TK.Half.Life NA 178.2 hours 1compartment NA NA Human Human -DTXSID1026293 Css NA 20.1 mg/L 3compartmentss NA 50% Human Human -DTXSID1026293 Css NA 136 mg/L 3compartmentss NA 95% Human Human -DTXSID1026293 Css NA 12.52 mg/L PBTK NA 50% Human Human -DTXSID1026293 Css NA 80.83 mg/L PBTK NA 95% Human Human -DTXSID1026293 Clint NA 2.101 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026293 Fup NA 0.0111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026293 Vd NA 1.109 L/kg 1compartment NA NA Rat Human -DTXSID1026293 Days.Css NA 16 Days PBTK NA NA Rat Human -DTXSID1026293 TK.Half.Life NA 61.34 hours 1compartment NA NA Rat Human -DTXSID1026293 Css NA 10.02 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026293 Css NA 53.81 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026293 Css NA 5.848 mg/L PBTK NA 50% Rat Human -DTXSID1026293 Css NA 29.74 mg/L PBTK NA 95% Rat Human -DTXSID1026457 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026457 Fup NA 0.5822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026457 Vd NA 1.036 L/kg 1compartment NA NA Human Human +DTXSID1026241 TK.Half.Life NA 5.045 hours 1compartment NA NA Rat Human +DTXSID1026241 Css NA 0.1382 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026241 Css NA 0.7931 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026241 Css NA 0.08838 mg/L PBTK NA 50% Rat Human +DTXSID1026241 Css NA 0.4996 mg/L PBTK NA 95% Rat Human +DTXSID1026293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026293 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026293 Vd NA 2.255 L/kg 1compartment NA NA Human Human +DTXSID1026293 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1026293 TK.Half.Life NA 34.26 hours 1compartment NA NA Human Human +DTXSID1026293 Css NA 2.264 mg/L 3compartmentss NA 50% Human Human +DTXSID1026293 Css NA 17.28 mg/L 3compartmentss NA 95% Human Human +DTXSID1026293 Css NA 1.466 mg/L PBTK NA 50% Human Human +DTXSID1026293 Css NA 10.88 mg/L PBTK NA 95% Human Human +DTXSID1026293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026293 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026293 Vd NA 1.676 L/kg 1compartment NA NA Rat Human +DTXSID1026293 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1026293 TK.Half.Life NA 9.713 hours 1compartment NA NA Rat Human +DTXSID1026293 Css NA 0.2899 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026293 Css NA 1.951 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026293 Css NA 0.1838 mg/L PBTK NA 50% Rat Human +DTXSID1026293 Css NA 1.202 mg/L PBTK NA 95% Rat Human +DTXSID1026457 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026457 Fup 0.557 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026457 Vd NA 1.01 L/kg 1compartment NA NA Human Human DTXSID1026457 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1026457 TK.Half.Life NA 12.11 hours 1compartment NA NA Human Human -DTXSID1026457 Css NA 1.259 mg/L 3compartmentss NA 50% Human Human -DTXSID1026457 Css NA 9.112 mg/L 3compartmentss NA 95% Human Human -DTXSID1026457 Css NA 1.052 mg/L PBTK NA 50% Human Human -DTXSID1026457 Css NA 5.818 mg/L PBTK NA 95% Human Human -DTXSID1026457 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026457 Fup NA 0.5822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026457 Vd NA 0.9561 L/kg 1compartment NA NA Rat Human +DTXSID1026457 TK.Half.Life NA 12.31 hours 1compartment NA NA Human Human +DTXSID1026457 Css NA 1.266 mg/L 3compartmentss NA 50% Human Human +DTXSID1026457 Css NA 8.912 mg/L 3compartmentss NA 95% Human Human +DTXSID1026457 Css NA 1.056 mg/L PBTK NA 50% Human Human +DTXSID1026457 Css NA 5.621 mg/L PBTK NA 95% Human Human +DTXSID1026457 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026457 Fup 0.557 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026457 Vd NA 0.9312 L/kg 1compartment NA NA Rat Human DTXSID1026457 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026457 TK.Half.Life NA 3.666 hours 1compartment NA NA Rat Human -DTXSID1026457 Css NA 0.3298 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026457 Css NA 2.067 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026457 Css NA 0.2664 mg/L PBTK NA 50% Rat Human -DTXSID1026457 Css NA 1.235 mg/L PBTK NA 95% Rat Human -DTXSID1026536 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026536 Fup NA 0.5909 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026536 Vd NA 0.6215 L/kg 1compartment NA NA Human Human +DTXSID1026457 TK.Half.Life NA 3.729 hours 1compartment NA NA Rat Human +DTXSID1026457 Css NA 0.07744 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026457 Css NA 0.4985 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026457 Css NA 0.06399 mg/L PBTK NA 50% Rat Human +DTXSID1026457 Css NA 0.3069 mg/L PBTK NA 95% Rat Human +DTXSID1026536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026536 Fup 0.181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026536 Vd NA 0.2992 L/kg 1compartment NA NA Human Human DTXSID1026536 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026536 TK.Half.Life NA 6.816 hours 1compartment NA NA Human Human -DTXSID1026536 Css NA 1.287 mg/L 3compartmentss NA 50% Human Human -DTXSID1026536 Css NA 8.613 mg/L 3compartmentss NA 95% Human Human -DTXSID1026536 Css NA 0.9976 mg/L PBTK NA 50% Human Human -DTXSID1026536 Css NA 5.438 mg/L PBTK NA 95% Human Human -DTXSID1026536 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026536 Fup NA 0.5909 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026536 Vd NA 0.6401 L/kg 1compartment NA NA Rat Human +DTXSID1026536 TK.Half.Life NA 0.5324 hours 1compartment NA NA Human Human +DTXSID1026536 Css NA 0.1252 mg/L 3compartmentss NA 50% Human Human +DTXSID1026536 Css NA 0.8856 mg/L 3compartmentss NA 95% Human Human +DTXSID1026536 Css NA 0.07969 mg/L PBTK NA 50% Human Human +DTXSID1026536 Css NA 0.5454 mg/L PBTK NA 95% Human Human +DTXSID1026536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026536 Fup 0.181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026536 Vd NA 0.3126 L/kg 1compartment NA NA Rat Human DTXSID1026536 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026536 TK.Half.Life NA 2.389 hours 1compartment NA NA Rat Human -DTXSID1026536 Css NA 0.3377 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026536 Css NA 2.075 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026536 Css NA 0.2526 mg/L PBTK NA 50% Rat Human -DTXSID1026536 Css NA 1.21 mg/L PBTK NA 95% Rat Human -DTXSID1026619 Clint NA 1.114 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026619 Fup NA 0.2596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026619 Vd NA 0.6091 L/kg 1compartment NA NA Human Human +DTXSID1026536 TK.Half.Life NA 0.3096 hours 1compartment NA NA Rat Human +DTXSID1026536 Css NA 0.01585 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026536 Css NA 0.08432 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026536 Css NA 0.00985 mg/L PBTK NA 50% Rat Human +DTXSID1026536 Css NA 0.05056 mg/L PBTK NA 95% Rat Human +DTXSID1026615 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026615 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026615 Vd NA 1.189 L/kg 1compartment NA NA Human Human +DTXSID1026615 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1026615 TK.Half.Life NA 18.69 hours 1compartment NA NA Human Human +DTXSID1026615 Css NA 1.57 mg/L 3compartmentss NA 50% Human Human +DTXSID1026615 Css NA 7.423 mg/L 3compartmentss NA 95% Human Human +DTXSID1026615 Css NA 1.277 mg/L PBTK NA 50% Human Human +DTXSID1026615 Css NA 4.949 mg/L PBTK NA 95% Human Human +DTXSID1026615 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026615 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026615 Vd NA 1.037 L/kg 1compartment NA NA Rat Human +DTXSID1026615 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1026615 TK.Half.Life NA 5.134 hours 1compartment NA NA Rat Human +DTXSID1026615 Css NA 0.09956 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026615 Css NA 0.4088 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026615 Css NA 0.08066 mg/L PBTK NA 50% Rat Human +DTXSID1026615 Css NA 0.2605 mg/L PBTK NA 95% Rat Human +DTXSID1026619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026619 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026619 Vd NA 2.534 L/kg 1compartment NA NA Human Human DTXSID1026619 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026619 TK.Half.Life NA 5.576 hours 1compartment NA NA Human Human -DTXSID1026619 Css NA 1.033 mg/L 3compartmentss NA 50% Human Human -DTXSID1026619 Css NA 4.602 mg/L 3compartmentss NA 95% Human Human -DTXSID1026619 Css NA 0.7267 mg/L PBTK NA 50% Human Human -DTXSID1026619 Css NA 2.932 mg/L PBTK NA 95% Human Human -DTXSID1026619 Clint NA 1.114 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026619 Fup NA 0.2596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026619 Vd NA 0.568 L/kg 1compartment NA NA Rat Human +DTXSID1026619 TK.Half.Life NA 9.774 hours 1compartment NA NA Human Human +DTXSID1026619 Css NA 0.4095 mg/L 3compartmentss NA 50% Human Human +DTXSID1026619 Css NA 2.767 mg/L 3compartmentss NA 95% Human Human +DTXSID1026619 Css NA 0.285 mg/L PBTK NA 50% Human Human +DTXSID1026619 Css NA 1.836 mg/L PBTK NA 95% Human Human +DTXSID1026619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026619 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026619 Vd NA 1.914 L/kg 1compartment NA NA Rat Human DTXSID1026619 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026619 TK.Half.Life NA 2.58 hours 1compartment NA NA Rat Human -DTXSID1026619 Css NA 0.4306 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026619 Css NA 1.562 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026619 Css NA 0.2879 mg/L PBTK NA 50% Rat Human -DTXSID1026619 Css NA 0.9124 mg/L PBTK NA 95% Rat Human +DTXSID1026619 TK.Half.Life NA 2.553 hours 1compartment NA NA Rat Human +DTXSID1026619 Css NA 0.052 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026619 Css NA 0.272 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026619 Css NA 0.03595 mg/L PBTK NA 50% Rat Human +DTXSID1026619 Css NA 0.1805 mg/L PBTK NA 95% Rat Human +DTXSID1026661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026661 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026661 Vd NA 0.9869 L/kg 1compartment NA NA Human Human +DTXSID1026661 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1026661 TK.Half.Life NA 0.9906 hours 1compartment NA NA Human Human +DTXSID1026661 Css NA 0.0394 mg/L 3compartmentss NA 50% Human Human +DTXSID1026661 Css NA 0.3457 mg/L 3compartmentss NA 95% Human Human +DTXSID1026661 Css NA 0.03152 mg/L PBTK NA 50% Human Human +DTXSID1026661 Css NA 0.2446 mg/L PBTK NA 95% Human Human +DTXSID1026661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026661 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026661 Vd NA 0.8985 L/kg 1compartment NA NA Rat Human +DTXSID1026661 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1026661 TK.Half.Life NA 0.4527 hours 1compartment NA NA Rat Human +DTXSID1026661 Css NA 0.004884 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026661 Css NA 0.03452 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026661 Css NA 0.003948 mg/L PBTK NA 50% Rat Human +DTXSID1026661 Css NA 0.02372 mg/L PBTK NA 95% Rat Human DTXSID1026665 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1026665 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026665 Vd NA 1.051 L/kg 1compartment NA NA Human Human +DTXSID1026665 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026665 Vd NA 0.6525 L/kg 1compartment NA NA Human Human DTXSID1026665 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026665 TK.Half.Life NA 6.911 hours 1compartment NA NA Human Human -DTXSID1026665 Css NA 0.7754 mg/L 3compartmentss NA 50% Human Human -DTXSID1026665 Css NA 5.579 mg/L 3compartmentss NA 95% Human Human -DTXSID1026665 Css NA 0.6979 mg/L PBTK NA 50% Human Human -DTXSID1026665 Css NA 3.604 mg/L PBTK NA 95% Human Human +DTXSID1026665 TK.Half.Life NA 9.41 hours 1compartment NA NA Human Human +DTXSID1026665 Css NA 1.539 mg/L 3compartmentss NA 50% Human Human +DTXSID1026665 Css NA 7.267 mg/L 3compartmentss NA 95% Human Human +DTXSID1026665 Css NA 1.173 mg/L PBTK NA 50% Human Human +DTXSID1026665 Css NA 4.632 mg/L PBTK NA 95% Human Human DTXSID1026665 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1026665 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026665 Vd NA 1.044 L/kg 1compartment NA NA Rat Human +DTXSID1026665 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026665 Vd NA 0.6446 L/kg 1compartment NA NA Rat Human DTXSID1026665 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026665 TK.Half.Life NA 2.311 hours 1compartment NA NA Rat Human -DTXSID1026665 Css NA 0.1954 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026665 Css NA 1.243 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026665 Css NA 0.1732 mg/L PBTK NA 50% Rat Human -DTXSID1026665 Css NA 0.7684 mg/L PBTK NA 95% Rat Human -DTXSID1026667 Clint NA 4.283 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026667 Fup NA 0.8389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026667 Vd NA 1.684 L/kg 1compartment NA NA Human Human +DTXSID1026665 TK.Half.Life NA 3.151 hours 1compartment NA NA Rat Human +DTXSID1026665 Css NA 0.09796 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026665 Css NA 0.4022 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026665 Css NA 0.07392 mg/L PBTK NA 50% Rat Human +DTXSID1026665 Css NA 0.2481 mg/L PBTK NA 95% Rat Human +DTXSID1026667 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026667 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026667 Vd NA 1.08 L/kg 1compartment NA NA Human Human DTXSID1026667 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026667 TK.Half.Life NA 2.583 hours 1compartment NA NA Human Human -DTXSID1026667 Css NA 0.1189 mg/L 3compartmentss NA 50% Human Human -DTXSID1026667 Css NA 0.9525 mg/L 3compartmentss NA 95% Human Human -DTXSID1026667 Css NA 0.1104 mg/L PBTK NA 50% Human Human -DTXSID1026667 Css NA 0.6894 mg/L PBTK NA 95% Human Human -DTXSID1026667 Clint NA 4.283 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026667 Fup NA 0.8389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026667 Vd NA 1.476 L/kg 1compartment NA NA Rat Human +DTXSID1026667 TK.Half.Life NA 1.248 hours 1compartment NA NA Human Human +DTXSID1026667 Css NA 0.0529 mg/L 3compartmentss NA 50% Human Human +DTXSID1026667 Css NA 0.4174 mg/L 3compartmentss NA 95% Human Human +DTXSID1026667 Css NA 0.04086 mg/L PBTK NA 50% Human Human +DTXSID1026667 Css NA 0.2906 mg/L PBTK NA 95% Human Human +DTXSID1026667 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026667 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026667 Vd NA 0.9378 L/kg 1compartment NA NA Rat Human DTXSID1026667 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026667 TK.Half.Life NA 1.1 hours 1compartment NA NA Rat Human -DTXSID1026667 Css NA 0.05513 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026667 Css NA 0.4053 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026667 Css NA 0.05115 mg/L PBTK NA 50% Rat Human -DTXSID1026667 Css NA 0.2648 mg/L PBTK NA 95% Rat Human -DTXSID1026740 Clint NA 126 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026740 Fup NA 0.1643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026740 Vd NA 1.812 L/kg 1compartment NA NA Human Human +DTXSID1026667 TK.Half.Life NA 0.5501 hours 1compartment NA NA Rat Human +DTXSID1026667 Css NA 0.006584 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026667 Css NA 0.03913 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026667 Css NA 0.005082 mg/L PBTK NA 50% Rat Human +DTXSID1026667 Css NA 0.02664 mg/L PBTK NA 95% Rat Human +DTXSID1026740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026740 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026740 Vd NA 2.803 L/kg 1compartment NA NA Human Human DTXSID1026740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026740 TK.Half.Life NA 1.876 hours 1compartment NA NA Human Human -DTXSID1026740 Css NA 0.03369 mg/L 3compartmentss NA 50% Human Human -DTXSID1026740 Css NA 0.2414 mg/L 3compartmentss NA 95% Human Human -DTXSID1026740 Css NA 0.02376 mg/L PBTK NA 50% Human Human -DTXSID1026740 Css NA 0.1634 mg/L PBTK NA 95% Human Human -DTXSID1026740 Clint NA 126 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026740 Fup NA 0.1643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026740 Vd NA 1.397 L/kg 1compartment NA NA Rat Human +DTXSID1026740 TK.Half.Life NA 9.515 hours 1compartment NA NA Human Human +DTXSID1026740 Css NA 0.3076 mg/L 3compartmentss NA 50% Human Human +DTXSID1026740 Css NA 1.963 mg/L 3compartmentss NA 95% Human Human +DTXSID1026740 Css NA 0.2227 mg/L PBTK NA 50% Human Human +DTXSID1026740 Css NA 1.371 mg/L PBTK NA 95% Human Human +DTXSID1026740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026740 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026740 Vd NA 2.125 L/kg 1compartment NA NA Rat Human DTXSID1026740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026740 TK.Half.Life NA 0.6484 hours 1compartment NA NA Rat Human -DTXSID1026740 Css NA 0.01865 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026740 Css NA 0.1025 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026740 Css NA 0.0125 mg/L PBTK NA 50% Rat Human -DTXSID1026740 Css NA 0.06737 mg/L PBTK NA 95% Rat Human +DTXSID1026740 TK.Half.Life NA 2.166 hours 1compartment NA NA Rat Human +DTXSID1026740 Css NA 0.03917 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026740 Css NA 0.1961 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026740 Css NA 0.02831 mg/L PBTK NA 50% Rat Human +DTXSID1026740 Css NA 0.1375 mg/L PBTK NA 95% Rat Human DTXSID1026792 Clint 32.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1026792 Fup 0.549 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1026792 Vd NA 1.22 L/kg 1compartment NA NA Human Human DTXSID1026792 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1026792 TK.Half.Life NA 1.014 hours 1compartment NA NA Human Human -DTXSID1026792 Css NA 0.02465 mg/L 3compartmentss NA 50% Human Human -DTXSID1026792 Css NA 0.2371 mg/L 3compartmentss NA 95% Human Human -DTXSID1026792 Css NA 0.02048 mg/L PBTK NA 50% Human Human -DTXSID1026792 Css NA 0.1814 mg/L PBTK NA 95% Human Human +DTXSID1026792 Css NA 0.01658 mg/L 3compartmentss NA 50% Human Human +DTXSID1026792 Css NA 0.2041 mg/L 3compartmentss NA 95% Human Human +DTXSID1026792 Css NA 0.01396 mg/L PBTK NA 50% Human Human +DTXSID1026792 Css NA 0.1562 mg/L PBTK NA 95% Human Human DTXSID1026792 Clint 32.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1026792 Fup 0.549 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1026792 Vd NA 1.084 L/kg 1compartment NA NA Rat Human DTXSID1026792 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1026792 TK.Half.Life NA 0.43 hours 1compartment NA NA Rat Human -DTXSID1026792 Css NA 0.0134 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026792 Css NA 0.1067 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026792 Css NA 0.01113 mg/L PBTK NA 50% Rat Human -DTXSID1026792 Css NA 0.07813 mg/L PBTK NA 95% Rat Human -DTXSID1026796 Clint NA 204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026796 Fup NA 0.825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026796 Vd NA 1.003 L/kg 1compartment NA NA Human Human +DTXSID1026792 Css NA 0.0005641 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026792 Css NA 0.008124 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026792 Css NA 0.0004718 mg/L PBTK NA 50% Rat Human +DTXSID1026792 Css NA 0.006138 mg/L PBTK NA 95% Rat Human +DTXSID1026796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026796 Fup 0.884 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026796 Vd NA 1.046 L/kg 1compartment NA NA Human Human DTXSID1026796 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026796 TK.Half.Life NA 0.5835 hours 1compartment NA NA Human Human -DTXSID1026796 Css NA 0.003034 mg/L 3compartmentss NA 50% Human Human -DTXSID1026796 Css NA 0.03089 mg/L 3compartmentss NA 95% Human Human -DTXSID1026796 Css NA 0.002594 mg/L PBTK NA 50% Human Human -DTXSID1026796 Css NA 0.02276 mg/L PBTK NA 95% Human Human -DTXSID1026796 Clint NA 204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026796 Fup NA 0.825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026796 Vd NA 0.9796 L/kg 1compartment NA NA Rat Human +DTXSID1026796 TK.Half.Life NA 0.7509 hours 1compartment NA NA Human Human +DTXSID1026796 Css NA 0.01832 mg/L 3compartmentss NA 50% Human Human +DTXSID1026796 Css NA 0.2162 mg/L 3compartmentss NA 95% Human Human +DTXSID1026796 Css NA 0.01586 mg/L PBTK NA 50% Human Human +DTXSID1026796 Css NA 0.1553 mg/L PBTK NA 95% Human Human +DTXSID1026796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026796 Fup 0.884 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026796 Vd NA 1.023 L/kg 1compartment NA NA Rat Human DTXSID1026796 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026796 TK.Half.Life NA 0.2492 hours 1compartment NA NA Rat Human -DTXSID1026796 Css NA 0.001541 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026796 Css NA 0.01592 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026796 Css NA 0.001308 mg/L PBTK NA 50% Rat Human -DTXSID1026796 Css NA 0.01089 mg/L PBTK NA 95% Rat Human +DTXSID1026796 TK.Half.Life NA 0.3531 hours 1compartment NA NA Rat Human +DTXSID1026796 Css NA 0.0006483 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026796 Css NA 0.008404 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026796 Css NA 0.000558 mg/L PBTK NA 50% Rat Human +DTXSID1026796 Css NA 0.006126 mg/L PBTK NA 95% Rat Human DTXSID1026879 Clint NA 1.503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1026879 Fup NA 0.6911 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026879 Vd NA 1.99 L/kg 1compartment NA NA Human Human +DTXSID1026879 Vd NA 1.789 L/kg 1compartment NA NA Human Human DTXSID1026879 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026879 TK.Half.Life NA 5.733 hours 1compartment NA NA Human Human -DTXSID1026879 Css NA 0.2501 mg/L 3compartmentss NA 50% Human Human -DTXSID1026879 Css NA 1.975 mg/L 3compartmentss NA 95% Human Human -DTXSID1026879 Css NA 0.261 mg/L PBTK NA 50% Human Human -DTXSID1026879 Css NA 1.441 mg/L PBTK NA 95% Human Human +DTXSID1026879 TK.Half.Life NA 5.204 hours 1compartment NA NA Human Human +DTXSID1026879 Css NA 0.2202 mg/L 3compartmentss NA 50% Human Human +DTXSID1026879 Css NA 1.768 mg/L 3compartmentss NA 95% Human Human +DTXSID1026879 Css NA 0.2184 mg/L PBTK NA 50% Human Human +DTXSID1026879 Css NA 1.248 mg/L PBTK NA 95% Human Human DTXSID1026879 Clint NA 1.503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1026879 Fup NA 0.6911 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026879 Vd NA 1.964 L/kg 1compartment NA NA Rat Human +DTXSID1026879 Vd NA 1.766 L/kg 1compartment NA NA Rat Human DTXSID1026879 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026879 TK.Half.Life NA 2.922 hours 1compartment NA NA Rat Human -DTXSID1026879 Css NA 0.09936 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026879 Css NA 0.8094 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026879 Css NA 0.1041 mg/L PBTK NA 50% Rat Human -DTXSID1026879 Css NA 0.5298 mg/L PBTK NA 95% Rat Human -DTXSID1026902 Clint NA 96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026902 Fup NA 0.3032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026902 Vd NA 3.847 L/kg 1compartment NA NA Human Human -DTXSID1026902 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026902 TK.Half.Life NA 3.285 hours 1compartment NA NA Human Human -DTXSID1026902 Css NA 0.01941 mg/L 3compartmentss NA 50% Human Human -DTXSID1026902 Css NA 0.132 mg/L 3compartmentss NA 95% Human Human -DTXSID1026902 Css NA 0.0163 mg/L PBTK NA 50% Human Human -DTXSID1026902 Css NA 0.1038 mg/L PBTK NA 95% Human Human -DTXSID1026902 Clint NA 96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026902 Fup NA 0.3032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026902 Vd NA 3.166 L/kg 1compartment NA NA Rat Human -DTXSID1026902 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026902 TK.Half.Life NA 1.033 hours 1compartment NA NA Rat Human -DTXSID1026902 Css NA 0.0106 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026902 Css NA 0.05973 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026902 Css NA 0.008716 mg/L PBTK NA 50% Rat Human -DTXSID1026902 Css NA 0.04485 mg/L PBTK NA 95% Rat Human -DTXSID1026904 Clint NA 124.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026904 Fup NA 0.5377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026904 Vd NA 0.9525 L/kg 1compartment NA NA Human Human +DTXSID1026879 TK.Half.Life NA 2.645 hours 1compartment NA NA Rat Human +DTXSID1026879 Css NA 0.006275 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026879 Css NA 0.06716 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026879 Css NA 0.006222 mg/L PBTK NA 50% Rat Human +DTXSID1026879 Css NA 0.04774 mg/L PBTK NA 95% Rat Human +DTXSID1026904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026904 Fup 0.565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026904 Vd NA 1.329 L/kg 1compartment NA NA Human Human DTXSID1026904 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026904 TK.Half.Life NA 0.6639 hours 1compartment NA NA Human Human -DTXSID1026904 Css NA 0.006909 mg/L 3compartmentss NA 50% Human Human -DTXSID1026904 Css NA 0.06996 mg/L 3compartmentss NA 95% Human Human -DTXSID1026904 Css NA 0.005626 mg/L PBTK NA 50% Human Human -DTXSID1026904 Css NA 0.04853 mg/L PBTK NA 95% Human Human -DTXSID1026904 Clint NA 124.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026904 Fup NA 0.5377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026904 Vd NA 0.8869 L/kg 1compartment NA NA Rat Human +DTXSID1026904 TK.Half.Life NA 1.23 hours 1compartment NA NA Human Human +DTXSID1026904 Css NA 0.03566 mg/L 3compartmentss NA 50% Human Human +DTXSID1026904 Css NA 0.3829 mg/L 3compartmentss NA 95% Human Human +DTXSID1026904 Css NA 0.03009 mg/L PBTK NA 50% Human Human +DTXSID1026904 Css NA 0.2645 mg/L PBTK NA 95% Human Human +DTXSID1026904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026904 Fup 0.565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026904 Vd NA 1.164 L/kg 1compartment NA NA Rat Human DTXSID1026904 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026904 TK.Half.Life NA 0.2776 hours 1compartment NA NA Rat Human -DTXSID1026904 Css NA 0.003714 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026904 Css NA 0.03244 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026904 Css NA 0.002911 mg/L PBTK NA 50% Rat Human -DTXSID1026904 Css NA 0.02185 mg/L PBTK NA 95% Rat Human -DTXSID1026908 Clint NA 8.178 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026908 Fup NA 0.5312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026908 Vd NA 1.64 L/kg 1compartment NA NA Human Human +DTXSID1026904 TK.Half.Life NA 0.5243 hours 1compartment NA NA Rat Human +DTXSID1026904 Css NA 0.004284 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026904 Css NA 0.03875 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026904 Css NA 0.003681 mg/L PBTK NA 50% Rat Human +DTXSID1026904 Css NA 0.02639 mg/L PBTK NA 95% Rat Human +DTXSID1026906 Clint 34.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID1026906 Fup 0.00699 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID1026906 Vd NA 0.4501 L/kg 1compartment NA NA Human Human +DTXSID1026906 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1026906 TK.Half.Life NA 5.146 hours 1compartment NA NA Human Human +DTXSID1026906 Css NA 1.087 mg/L 3compartmentss NA 50% Human Human +DTXSID1026906 Css NA 9.485 mg/L 3compartmentss NA 95% Human Human +DTXSID1026906 Css NA 0.666 mg/L PBTK NA 50% Human Human +DTXSID1026906 Css NA 5.6 mg/L PBTK NA 95% Human Human +DTXSID1026906 Clint 34.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID1026906 Fup 0.00699 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID1026906 Vd NA 0.4283 L/kg 1compartment NA NA Rat Human +DTXSID1026906 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1026906 TK.Half.Life NA 3.288 hours 1compartment NA NA Rat Human +DTXSID1026906 Css NA 0.1438 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026906 Css NA 0.9585 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026906 Css NA 0.08524 mg/L PBTK NA 50% Rat Human +DTXSID1026906 Css NA 0.5538 mg/L PBTK NA 95% Rat Human +DTXSID1026908 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026908 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026908 Vd NA 1.525 L/kg 1compartment NA NA Human Human DTXSID1026908 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026908 TK.Half.Life NA 2.565 hours 1compartment NA NA Human Human -DTXSID1026908 Css NA 0.111 mg/L 3compartmentss NA 50% Human Human -DTXSID1026908 Css NA 0.8493 mg/L 3compartmentss NA 95% Human Human -DTXSID1026908 Css NA 0.09378 mg/L PBTK NA 50% Human Human -DTXSID1026908 Css NA 0.604 mg/L PBTK NA 95% Human Human -DTXSID1026908 Clint NA 8.178 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026908 Fup NA 0.5312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026908 Vd NA 1.373 L/kg 1compartment NA NA Rat Human +DTXSID1026908 TK.Half.Life NA 1.628 hours 1compartment NA NA Human Human +DTXSID1026908 Css NA 0.04538 mg/L 3compartmentss NA 50% Human Human +DTXSID1026908 Css NA 0.3823 mg/L 3compartmentss NA 95% Human Human +DTXSID1026908 Css NA 0.03734 mg/L PBTK NA 50% Human Human +DTXSID1026908 Css NA 0.2759 mg/L PBTK NA 95% Human Human +DTXSID1026908 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026908 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026908 Vd NA 1.275 L/kg 1compartment NA NA Rat Human DTXSID1026908 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026908 TK.Half.Life NA 1.047 hours 1compartment NA NA Rat Human -DTXSID1026908 Css NA 0.05625 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026908 Css NA 0.3487 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026908 Css NA 0.04634 mg/L PBTK NA 50% Rat Human -DTXSID1026908 Css NA 0.2296 mg/L PBTK NA 95% Rat Human -DTXSID1026954 Clint NA 14.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026954 Fup NA 0.8492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1026954 Vd NA 0.9768 L/kg 1compartment NA NA Human Human +DTXSID1026908 TK.Half.Life NA 0.6545 hours 1compartment NA NA Rat Human +DTXSID1026908 Css NA 0.005666 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026908 Css NA 0.03574 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026908 Css NA 0.004715 mg/L PBTK NA 50% Rat Human +DTXSID1026908 Css NA 0.02589 mg/L PBTK NA 95% Rat Human +DTXSID1026954 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026954 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1026954 Vd NA 0.6571 L/kg 1compartment NA NA Human Human DTXSID1026954 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1026954 TK.Half.Life NA 0.8099 hours 1compartment NA NA Human Human -DTXSID1026954 Css NA 0.04018 mg/L 3compartmentss NA 50% Human Human -DTXSID1026954 Css NA 0.3791 mg/L 3compartmentss NA 95% Human Human -DTXSID1026954 Css NA 0.03426 mg/L PBTK NA 50% Human Human -DTXSID1026954 Css NA 0.2745 mg/L PBTK NA 95% Human Human -DTXSID1026954 Clint NA 14.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026954 Fup NA 0.8492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1026954 Vd NA 0.9637 L/kg 1compartment NA NA Rat Human +DTXSID1026954 TK.Half.Life NA 0.839 hours 1compartment NA NA Human Human +DTXSID1026954 Css NA 0.06343 mg/L 3compartmentss NA 50% Human Human +DTXSID1026954 Css NA 0.4871 mg/L 3compartmentss NA 95% Human Human +DTXSID1026954 Css NA 0.04563 mg/L PBTK NA 50% Human Human +DTXSID1026954 Css NA 0.3265 mg/L PBTK NA 95% Human Human +DTXSID1026954 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026954 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1026954 Vd NA 0.6175 L/kg 1compartment NA NA Rat Human DTXSID1026954 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1026954 TK.Half.Life NA 0.3981 hours 1compartment NA NA Rat Human -DTXSID1026954 Css NA 0.01974 mg/L 3compartmentss NA 50% Rat Human -DTXSID1026954 Css NA 0.1647 mg/L 3compartmentss NA 95% Rat Human -DTXSID1026954 Css NA 0.01674 mg/L PBTK NA 50% Rat Human -DTXSID1026954 Css NA 0.1108 mg/L PBTK NA 95% Rat Human -DTXSID1027007 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027007 Fup NA 0.9671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027007 Vd NA 1.115 L/kg 1compartment NA NA Human Human -DTXSID1027007 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027007 TK.Half.Life NA 7.66 hours 1compartment NA NA Human Human -DTXSID1027007 Css NA 0.84 mg/L 3compartmentss NA 50% Human Human -DTXSID1027007 Css NA 4.769 mg/L 3compartmentss NA 95% Human Human -DTXSID1027007 Css NA 0.7485 mg/L PBTK NA 50% Human Human -DTXSID1027007 Css NA 3.256 mg/L PBTK NA 95% Human Human -DTXSID1027007 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027007 Fup NA 0.9671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027007 Vd NA 1.089 L/kg 1compartment NA NA Rat Human -DTXSID1027007 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027007 TK.Half.Life NA 2.499 hours 1compartment NA NA Rat Human -DTXSID1027007 Css NA 0.2105 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027007 Css NA 1.198 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027007 Css NA 0.1851 mg/L PBTK NA 50% Rat Human -DTXSID1027007 Css NA 0.7475 mg/L PBTK NA 95% Rat Human +DTXSID1026954 TK.Half.Life NA 0.4148 hours 1compartment NA NA Rat Human +DTXSID1026954 Css NA 0.00804 mg/L 3compartmentss NA 50% Rat Human +DTXSID1026954 Css NA 0.04773 mg/L 3compartmentss NA 95% Rat Human +DTXSID1026954 Css NA 0.005732 mg/L PBTK NA 50% Rat Human +DTXSID1026954 Css NA 0.03189 mg/L PBTK NA 95% Rat Human DTXSID1027134 Clint 9.993 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID1027134 Fup NA 0.0322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027134 Vd NA 1.305 L/kg 1compartment NA NA Human Human -DTXSID1027134 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1027134 TK.Half.Life NA 16.14 hours 1compartment NA NA Human Human -DTXSID1027134 Css NA 2.042 mg/L 3compartmentss NA 50% Human Human -DTXSID1027134 Css NA 16 mg/L 3compartmentss NA 95% Human Human -DTXSID1027134 Css NA 1.281 mg/L PBTK NA 50% Human Human -DTXSID1027134 Css NA 9.556 mg/L PBTK NA 95% Human Human +DTXSID1027134 Fup 0.0713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027134 Vd NA 1.256 L/kg 1compartment NA NA Human Human +DTXSID1027134 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1027134 TK.Half.Life NA 7.808 hours 1compartment NA NA Human Human +DTXSID1027134 Css NA 0.8092 mg/L 3compartmentss NA 50% Human Human +DTXSID1027134 Css NA 5.357 mg/L 3compartmentss NA 95% Human Human +DTXSID1027134 Css NA 0.5261 mg/L PBTK NA 50% Human Human +DTXSID1027134 Css NA 3.346 mg/L PBTK NA 95% Human Human DTXSID1027134 Clint 9.993 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID1027134 Fup NA 0.0322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027134 Vd NA 0.9728 L/kg 1compartment NA NA Rat Human +DTXSID1027134 Fup 0.0713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027134 Vd NA 0.9932 L/kg 1compartment NA NA Rat Human DTXSID1027134 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027134 TK.Half.Life NA 6.484 hours 1compartment NA NA Rat Human -DTXSID1027134 Css NA 1.119 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027134 Css NA 7.119 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027134 Css NA 0.6573 mg/L PBTK NA 50% Rat Human -DTXSID1027134 Css NA 3.969 mg/L PBTK NA 95% Rat Human -DTXSID1027188 Clint NA 2.096 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027188 Fup NA 0.9363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027188 Vd NA 1.119 L/kg 1compartment NA NA Human Human +DTXSID1027134 TK.Half.Life NA 3.426 hours 1compartment NA NA Rat Human +DTXSID1027134 Css NA 0.1036 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027134 Css NA 0.5293 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027134 Css NA 0.06587 mg/L PBTK NA 50% Rat Human +DTXSID1027134 Css NA 0.3197 mg/L PBTK NA 95% Rat Human +DTXSID1027188 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027188 Fup 0.636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027188 Vd NA 1.13 L/kg 1compartment NA NA Human Human DTXSID1027188 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027188 TK.Half.Life NA 2.132 hours 1compartment NA NA Human Human -DTXSID1027188 Css NA 0.196 mg/L 3compartmentss NA 50% Human Human -DTXSID1027188 Css NA 1.371 mg/L 3compartmentss NA 95% Human Human -DTXSID1027188 Css NA 0.174 mg/L PBTK NA 50% Human Human -DTXSID1027188 Css NA 0.9583 mg/L PBTK NA 95% Human Human -DTXSID1027188 Clint NA 2.096 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027188 Fup NA 0.9363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027188 Vd NA 1.087 L/kg 1compartment NA NA Rat Human +DTXSID1027188 TK.Half.Life NA 0.9698 hours 1compartment NA NA Human Human +DTXSID1027188 Css NA 0.0241 mg/L 3compartmentss NA 50% Human Human +DTXSID1027188 Css NA 0.2915 mg/L 3compartmentss NA 95% Human Human +DTXSID1027188 Css NA 0.02023 mg/L PBTK NA 50% Human Human +DTXSID1027188 Css NA 0.2062 mg/L PBTK NA 95% Human Human +DTXSID1027188 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027188 Fup 0.636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027188 Vd NA 1.038 L/kg 1compartment NA NA Rat Human DTXSID1027188 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027188 TK.Half.Life NA 1.056 hours 1compartment NA NA Rat Human -DTXSID1027188 Css NA 0.08212 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027188 Css NA 0.5164 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027188 Css NA 0.07244 mg/L PBTK NA 50% Rat Human -DTXSID1027188 Css NA 0.3229 mg/L PBTK NA 95% Rat Human -DTXSID1027219 Clint NA 0.03393 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027219 Fup NA 0.1766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027219 Vd NA 0.3792 L/kg 1compartment NA NA Human Human -DTXSID1027219 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1027219 TK.Half.Life NA 13.16 hours 1compartment NA NA Human Human -DTXSID1027219 Css NA 4.26 mg/L 3compartmentss NA 50% Human Human -DTXSID1027219 Css NA 16.23 mg/L 3compartmentss NA 95% Human Human -DTXSID1027219 Css NA 2.838 mg/L PBTK NA 50% Human Human -DTXSID1027219 Css NA 9.924 mg/L PBTK NA 95% Human Human -DTXSID1027219 Clint NA 0.03393 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027219 Fup NA 0.1766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027219 Vd NA 0.376 L/kg 1compartment NA NA Rat Human +DTXSID1027188 TK.Half.Life NA 0.4359 hours 1compartment NA NA Rat Human +DTXSID1027188 Css NA 0.0008513 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027188 Css NA 0.01244 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027188 Css NA 0.0007183 mg/L PBTK NA 50% Rat Human +DTXSID1027188 Css NA 0.008529 mg/L PBTK NA 95% Rat Human +DTXSID1027219 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027219 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027219 Vd NA 0.4474 L/kg 1compartment NA NA Human Human +DTXSID1027219 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1027219 TK.Half.Life NA 1.012 hours 1compartment NA NA Human Human +DTXSID1027219 Css NA 0.1912 mg/L 3compartmentss NA 50% Human Human +DTXSID1027219 Css NA 1.224 mg/L 3compartmentss NA 95% Human Human +DTXSID1027219 Css NA 0.1355 mg/L PBTK NA 50% Human Human +DTXSID1027219 Css NA 0.7931 mg/L PBTK NA 95% Human Human +DTXSID1027219 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027219 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027219 Vd NA 0.4511 L/kg 1compartment NA NA Rat Human DTXSID1027219 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027219 TK.Half.Life NA 4.569 hours 1compartment NA NA Rat Human -DTXSID1027219 Css NA 1.248 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027219 Css NA 3.992 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027219 Css NA 0.7844 mg/L PBTK NA 50% Rat Human -DTXSID1027219 Css NA 2.278 mg/L PBTK NA 95% Rat Human -DTXSID1027265 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027265 Fup NA 0.9243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027265 Vd NA 1.371 L/kg 1compartment NA NA Human Human -DTXSID1027265 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1027265 TK.Half.Life NA 10.39 hours 1compartment NA NA Human Human -DTXSID1027265 Css NA 0.8012 mg/L 3compartmentss NA 50% Human Human -DTXSID1027265 Css NA 3.154 mg/L 3compartmentss NA 95% Human Human -DTXSID1027265 Css NA 0.7497 mg/L PBTK NA 50% Human Human -DTXSID1027265 Css NA 2.315 mg/L PBTK NA 95% Human Human -DTXSID1027265 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027265 Fup NA 0.9243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027265 Vd NA 1.271 L/kg 1compartment NA NA Rat Human +DTXSID1027219 TK.Half.Life NA 0.5762 hours 1compartment NA NA Rat Human +DTXSID1027219 Css NA 0.02239 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027219 Css NA 0.1078 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027219 Css NA 0.01577 mg/L PBTK NA 50% Rat Human +DTXSID1027219 Css NA 0.06763 mg/L PBTK NA 95% Rat Human +DTXSID1027265 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027265 Fup 0.702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027265 Vd NA 0.7525 L/kg 1compartment NA NA Human Human +DTXSID1027265 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1027265 TK.Half.Life NA 6.966 hours 1compartment NA NA Human Human +DTXSID1027265 Css NA 0.9148 mg/L 3compartmentss NA 50% Human Human +DTXSID1027265 Css NA 6.268 mg/L 3compartmentss NA 95% Human Human +DTXSID1027265 Css NA 0.7554 mg/L PBTK NA 50% Human Human +DTXSID1027265 Css NA 3.976 mg/L PBTK NA 95% Human Human +DTXSID1027265 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027265 Fup 0.702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027265 Vd NA 0.7629 L/kg 1compartment NA NA Rat Human DTXSID1027265 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027265 TK.Half.Life NA 3.092 hours 1compartment NA NA Rat Human -DTXSID1027265 Css NA 0.2055 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027265 Css NA 0.7607 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027265 Css NA 0.1891 mg/L PBTK NA 50% Rat Human -DTXSID1027265 Css NA 0.5165 mg/L PBTK NA 95% Rat Human -DTXSID1027344 Clint NA 4.952 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027344 Fup NA 0.2223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027344 Vd NA 2.667 L/kg 1compartment NA NA Human Human -DTXSID1027344 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1027344 TK.Half.Life NA 14.43 hours 1compartment NA NA Human Human -DTXSID1027344 Css NA 0.5226 mg/L 3compartmentss NA 50% Human Human -DTXSID1027344 Css NA 2.745 mg/L 3compartmentss NA 95% Human Human -DTXSID1027344 Css NA 0.4312 mg/L PBTK NA 50% Human Human -DTXSID1027344 Css NA 2.049 mg/L PBTK NA 95% Human Human -DTXSID1027344 Clint NA 4.952 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027344 Fup NA 0.2223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027344 Vd NA 2.265 L/kg 1compartment NA NA Rat Human +DTXSID1027265 TK.Half.Life NA 2.399 hours 1compartment NA NA Rat Human +DTXSID1027265 Css NA 0.01729 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027265 Css NA 0.1469 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027265 Css NA 0.01376 mg/L PBTK NA 50% Rat Human +DTXSID1027265 Css NA 0.09226 mg/L PBTK NA 95% Rat Human +DTXSID1027344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027344 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027344 Vd NA 2.246 L/kg 1compartment NA NA Human Human +DTXSID1027344 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1027344 TK.Half.Life NA 5.026 hours 1compartment NA NA Human Human +DTXSID1027344 Css NA 0.1921 mg/L 3compartmentss NA 50% Human Human +DTXSID1027344 Css NA 1.536 mg/L 3compartmentss NA 95% Human Human +DTXSID1027344 Css NA 0.145 mg/L PBTK NA 50% Human Human +DTXSID1027344 Css NA 1.058 mg/L PBTK NA 95% Human Human +DTXSID1027344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027344 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027344 Vd NA 1.896 L/kg 1compartment NA NA Rat Human DTXSID1027344 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027344 TK.Half.Life NA 5.131 hours 1compartment NA NA Rat Human -DTXSID1027344 Css NA 0.2612 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027344 Css NA 1.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027344 Css NA 0.2088 mg/L PBTK NA 50% Rat Human -DTXSID1027344 Css NA 0.7111 mg/L PBTK NA 95% Rat Human -DTXSID1027346 Clint NA 167.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027346 Fup NA 0.1666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027346 Vd NA 3.018 L/kg 1compartment NA NA Human Human -DTXSID1027346 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027346 TK.Half.Life NA 5.089 hours 1compartment NA NA Human Human -DTXSID1027346 Css NA 0.1086 mg/L 3compartmentss NA 50% Human Human -DTXSID1027346 Css NA 0.7219 mg/L 3compartmentss NA 95% Human Human -DTXSID1027346 Css NA 0.0767 mg/L PBTK NA 50% Human Human -DTXSID1027346 Css NA 0.4897 mg/L PBTK NA 95% Human Human -DTXSID1027346 Clint NA 167.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027346 Fup NA 0.1666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027346 Vd NA 2.271 L/kg 1compartment NA NA Rat Human -DTXSID1027346 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027346 TK.Half.Life NA 1.204 hours 1compartment NA NA Rat Human -DTXSID1027346 Css NA 0.06162 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027346 Css NA 0.3176 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027346 Css NA 0.04155 mg/L PBTK NA 50% Rat Human -DTXSID1027346 Css NA 0.208 mg/L PBTK NA 95% Rat Human -DTXSID1027390 Clint NA 1.444 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027390 Fup NA 0.3299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027390 Vd NA 0.4313 L/kg 1compartment NA NA Human Human -DTXSID1027390 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027390 TK.Half.Life NA 2.43 hours 1compartment NA NA Human Human -DTXSID1027390 Css NA 0.623 mg/L 3compartmentss NA 50% Human Human -DTXSID1027390 Css NA 3.023 mg/L 3compartmentss NA 95% Human Human -DTXSID1027390 Css NA 0.438 mg/L PBTK NA 50% Human Human -DTXSID1027390 Css NA 1.942 mg/L PBTK NA 95% Human Human -DTXSID1027390 Clint NA 1.444 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027390 Fup NA 0.3299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027390 Vd NA 0.4476 L/kg 1compartment NA NA Rat Human -DTXSID1027390 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027390 TK.Half.Life NA 1.328 hours 1compartment NA NA Rat Human -DTXSID1027390 Css NA 0.277 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027390 Css NA 1.054 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027390 Css NA 0.184 mg/L PBTK NA 50% Rat Human -DTXSID1027390 Css NA 0.6228 mg/L PBTK NA 95% Rat Human -DTXSID1027394 Clint NA 0.2563 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027394 Fup NA 0.1308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027394 Vd NA 0.4596 L/kg 1compartment NA NA Human Human -DTXSID1027394 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1027394 TK.Half.Life NA 16.04 hours 1compartment NA NA Human Human -DTXSID1027394 Css NA 4.842 mg/L 3compartmentss NA 50% Human Human -DTXSID1027394 Css NA 23.64 mg/L 3compartmentss NA 95% Human Human -DTXSID1027394 Css NA 3.218 mg/L PBTK NA 50% Human Human -DTXSID1027394 Css NA 14.24 mg/L PBTK NA 95% Human Human -DTXSID1027394 Clint NA 0.2563 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027394 Fup NA 0.1308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027394 Vd NA 0.4351 L/kg 1compartment NA NA Rat Human -DTXSID1027394 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027394 TK.Half.Life NA 6.08 hours 1compartment NA NA Rat Human -DTXSID1027394 Css NA 1.625 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027394 Css NA 6.885 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027394 Css NA 1.022 mg/L PBTK NA 50% Rat Human -DTXSID1027394 Css NA 3.881 mg/L PBTK NA 95% Rat Human -DTXSID1027396 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027396 Fup NA 0.0248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027396 Vd NA 3.123 L/kg 1compartment NA NA Human Human -DTXSID1027396 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID1027396 TK.Half.Life NA 110200 hours 1compartment NA NA Human Human -DTXSID1027396 Css NA 3992 mg/L 3compartmentss NA 50% Human Human -DTXSID1027396 Css NA 10010 mg/L 3compartmentss NA 95% Human Human -DTXSID1027396 Css NA 2774 mg/L PBTK NA 50% Human Human -DTXSID1027396 Css NA 6532 mg/L PBTK NA 95% Human Human -DTXSID1027396 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027396 Fup NA 0.0248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027396 Vd NA 2.339 L/kg 1compartment NA NA Rat Human -DTXSID1027396 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID1027396 TK.Half.Life NA 6863 hours 1compartment NA NA Rat Human -DTXSID1027396 Css NA 1092 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027396 Css NA 2176 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027396 Css NA 727 mg/L PBTK NA 50% Rat Human -DTXSID1027396 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID1027425 Clint NA 0.1334 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027425 Fup NA 0.116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027425 Vd NA 0.2715 L/kg 1compartment NA NA Human Human -DTXSID1027425 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1027425 TK.Half.Life NA 12.42 hours 1compartment NA NA Human Human -DTXSID1027425 Css NA 6.928 mg/L 3compartmentss NA 50% Human Human -DTXSID1027425 Css NA 32.49 mg/L 3compartmentss NA 95% Human Human -DTXSID1027425 Css NA 4.291 mg/L PBTK NA 50% Human Human -DTXSID1027425 Css NA 19.1 mg/L PBTK NA 95% Human Human -DTXSID1027425 Clint NA 0.1334 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027425 Fup NA 0.116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027425 Vd NA 0.268 L/kg 1compartment NA NA Rat Human +DTXSID1027344 TK.Half.Life NA 2.033 hours 1compartment NA NA Rat Human +DTXSID1027344 Css NA 0.02464 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027344 Css NA 0.1499 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027344 Css NA 0.01854 mg/L PBTK NA 50% Rat Human +DTXSID1027344 Css NA 0.1019 mg/L PBTK NA 95% Rat Human +DTXSID1027425 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027425 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027425 Vd NA 0.4005 L/kg 1compartment NA NA Human Human +DTXSID1027425 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1027425 TK.Half.Life NA 0.5501 hours 1compartment NA NA Human Human +DTXSID1027425 Css NA 0.07404 mg/L 3compartmentss NA 50% Human Human +DTXSID1027425 Css NA 0.5718 mg/L 3compartmentss NA 95% Human Human +DTXSID1027425 Css NA 0.05015 mg/L PBTK NA 50% Human Human +DTXSID1027425 Css NA 0.3645 mg/L PBTK NA 95% Human Human +DTXSID1027425 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027425 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027425 Vd NA 0.3969 L/kg 1compartment NA NA Rat Human DTXSID1027425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027425 TK.Half.Life NA 4.603 hours 1compartment NA NA Rat Human -DTXSID1027425 Css NA 2.219 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027425 Css NA 8.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027425 Css NA 1.281 mg/L PBTK NA 50% Rat Human -DTXSID1027425 Css NA 4.824 mg/L PBTK NA 95% Rat Human -DTXSID1027427 Clint NA 0.6562 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027427 Fup NA 0.8386 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027427 Vd NA 2.303 L/kg 1compartment NA NA Human Human -DTXSID1027427 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027427 TK.Half.Life NA 8.8 hours 1compartment NA NA Human Human -DTXSID1027427 Css NA 0.358 mg/L 3compartmentss NA 50% Human Human -DTXSID1027427 Css NA 2.626 mg/L 3compartmentss NA 95% Human Human -DTXSID1027427 Css NA 0.3824 mg/L PBTK NA 50% Human Human -DTXSID1027427 Css NA 1.879 mg/L PBTK NA 95% Human Human -DTXSID1027427 Clint NA 0.6562 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027427 Fup NA 0.8386 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027427 Vd NA 2.335 L/kg 1compartment NA NA Rat Human +DTXSID1027425 TK.Half.Life NA 0.29 hours 1compartment NA NA Rat Human +DTXSID1027425 Css NA 0.009448 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027425 Css NA 0.05377 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027425 Css NA 0.006357 mg/L PBTK NA 50% Rat Human +DTXSID1027425 Css NA 0.03329 mg/L PBTK NA 95% Rat Human +DTXSID1027427 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027427 Fup 0.525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027427 Vd NA 1.262 L/kg 1compartment NA NA Human Human +DTXSID1027427 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1027427 TK.Half.Life NA 15.55 hours 1compartment NA NA Human Human +DTXSID1027427 Css NA 1.033 mg/L 3compartmentss NA 50% Human Human +DTXSID1027427 Css NA 6.438 mg/L 3compartmentss NA 95% Human Human +DTXSID1027427 Css NA 0.9084 mg/L PBTK NA 50% Human Human +DTXSID1027427 Css NA 4.238 mg/L PBTK NA 95% Human Human +DTXSID1027427 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027427 Fup 0.525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027427 Vd NA 1.281 L/kg 1compartment NA NA Rat Human DTXSID1027427 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027427 TK.Half.Life NA 4.075 hours 1compartment NA NA Rat Human -DTXSID1027427 Css NA 0.1227 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027427 Css NA 0.9075 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027427 Css NA 0.1316 mg/L PBTK NA 50% Rat Human -DTXSID1027427 Css NA 0.5967 mg/L PBTK NA 95% Rat Human -DTXSID1027429 Clint NA 5.333 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027429 Fup NA 0.0828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027429 Vd NA 3.053 L/kg 1compartment NA NA Human Human -DTXSID1027429 Days.Css NA 29 Days PBTK NA NA Human Human -DTXSID1027429 TK.Half.Life NA 156.2 hours 1compartment NA NA Human Human -DTXSID1027429 Css NA 6.439 mg/L 3compartmentss NA 50% Human Human -DTXSID1027429 Css NA 37.12 mg/L 3compartmentss NA 95% Human Human -DTXSID1027429 Css NA 4.458 mg/L PBTK NA 50% Human Human -DTXSID1027429 Css NA 25.25 mg/L PBTK NA 95% Human Human -DTXSID1027429 Clint NA 5.333 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027429 Fup NA 0.0828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027429 Vd NA 2.291 L/kg 1compartment NA NA Rat Human -DTXSID1027429 Days.Css NA 16 Days PBTK NA NA Rat Human -DTXSID1027429 TK.Half.Life NA 22.24 hours 1compartment NA NA Rat Human -DTXSID1027429 Css NA 3.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027429 Css NA 15.28 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027429 Css NA 2.332 mg/L PBTK NA 50% Rat Human -DTXSID1027429 Css NA 9.928 mg/L PBTK NA 95% Rat Human -DTXSID1027479 Clint NA 25.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027479 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027479 Vd NA 2.539 L/kg 1compartment NA NA Human Human -DTXSID1027479 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1027479 TK.Half.Life NA 19.96 hours 1compartment NA NA Human Human -DTXSID1027479 Css NA 1.059 mg/L 3compartmentss NA 50% Human Human -DTXSID1027479 Css NA 6.876 mg/L 3compartmentss NA 95% Human Human -DTXSID1027479 Css NA 0.7065 mg/L PBTK NA 50% Human Human -DTXSID1027479 Css NA 4.421 mg/L PBTK NA 95% Human Human -DTXSID1027479 Clint NA 25.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027479 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027479 Vd NA 1.897 L/kg 1compartment NA NA Rat Human +DTXSID1027427 TK.Half.Life NA 5.382 hours 1compartment NA NA Rat Human +DTXSID1027427 Css NA 0.01949 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027427 Css NA 0.1606 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027427 Css NA 0.01654 mg/L PBTK NA 50% Rat Human +DTXSID1027427 Css NA 0.1076 mg/L PBTK NA 95% Rat Human +DTXSID1027429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027429 Fup 0.0493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027429 Vd NA 2.83 L/kg 1compartment NA NA Human Human +DTXSID1027429 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1027429 TK.Half.Life NA 28.64 hours 1compartment NA NA Human Human +DTXSID1027429 Css NA 1.235 mg/L 3compartmentss NA 50% Human Human +DTXSID1027429 Css NA 8.235 mg/L 3compartmentss NA 95% Human Human +DTXSID1027429 Css NA 0.8441 mg/L PBTK NA 50% Human Human +DTXSID1027429 Css NA 5.435 mg/L PBTK NA 95% Human Human +DTXSID1027429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027429 Fup 0.0493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027429 Vd NA 2.121 L/kg 1compartment NA NA Rat Human +DTXSID1027429 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1027429 TK.Half.Life NA 5.622 hours 1compartment NA NA Rat Human +DTXSID1027429 Css NA 0.1602 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027429 Css NA 0.8788 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027429 Css NA 0.1078 mg/L PBTK NA 50% Rat Human +DTXSID1027429 Css NA 0.5795 mg/L PBTK NA 95% Rat Human +DTXSID1027479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027479 Fup 0.0494 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027479 Vd NA 2.667 L/kg 1compartment NA NA Human Human +DTXSID1027479 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1027479 TK.Half.Life NA 22.24 hours 1compartment NA NA Human Human +DTXSID1027479 Css NA 1.033 mg/L 3compartmentss NA 50% Human Human +DTXSID1027479 Css NA 6.942 mg/L 3compartmentss NA 95% Human Human +DTXSID1027479 Css NA 0.6996 mg/L PBTK NA 50% Human Human +DTXSID1027479 Css NA 4.544 mg/L PBTK NA 95% Human Human +DTXSID1027479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027479 Fup 0.0494 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027479 Vd NA 1.997 L/kg 1compartment NA NA Rat Human DTXSID1027479 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1027479 TK.Half.Life NA 4.895 hours 1compartment NA NA Rat Human -DTXSID1027479 Css NA 0.588 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027479 Css NA 3.127 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027479 Css NA 0.3718 mg/L PBTK NA 50% Rat Human -DTXSID1027479 Css NA 1.952 mg/L PBTK NA 95% Rat Human -DTXSID1027500 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027500 Fup NA 0.9139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027500 Vd NA 0.981 L/kg 1compartment NA NA Human Human +DTXSID1027479 TK.Half.Life NA 4.99 hours 1compartment NA NA Rat Human +DTXSID1027479 Css NA 0.1344 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027479 Css NA 0.7175 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027479 Css NA 0.08986 mg/L PBTK NA 50% Rat Human +DTXSID1027479 Css NA 0.4699 mg/L PBTK NA 95% Rat Human +DTXSID1027500 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027500 Fup 0.746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027500 Vd NA 0.8065 L/kg 1compartment NA NA Human Human DTXSID1027500 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027500 TK.Half.Life NA 7.041 hours 1compartment NA NA Human Human -DTXSID1027500 Css NA 0.8384 mg/L 3compartmentss NA 50% Human Human -DTXSID1027500 Css NA 3.386 mg/L 3compartmentss NA 95% Human Human -DTXSID1027500 Css NA 0.7362 mg/L PBTK NA 50% Human Human -DTXSID1027500 Css NA 2.399 mg/L PBTK NA 95% Human Human -DTXSID1027500 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027500 Fup NA 0.9139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027500 Vd NA 0.9758 L/kg 1compartment NA NA Rat Human +DTXSID1027500 TK.Half.Life NA 7.04 hours 1compartment NA NA Human Human +DTXSID1027500 Css NA 0.8734 mg/L 3compartmentss NA 50% Human Human +DTXSID1027500 Css NA 5.477 mg/L 3compartmentss NA 95% Human Human +DTXSID1027500 Css NA 0.727 mg/L PBTK NA 50% Human Human +DTXSID1027500 Css NA 3.473 mg/L PBTK NA 95% Human Human +DTXSID1027500 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027500 Fup 0.746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027500 Vd NA 0.813 L/kg 1compartment NA NA Rat Human DTXSID1027500 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027500 TK.Half.Life NA 2.362 hours 1compartment NA NA Rat Human -DTXSID1027500 Css NA 0.214 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027500 Css NA 0.8072 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027500 Css NA 0.1845 mg/L PBTK NA 50% Rat Human -DTXSID1027500 Css NA 0.527 mg/L PBTK NA 95% Rat Human -DTXSID1027502 Clint NA 0.8918 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027502 Fup NA 0.849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027502 Vd NA 1.003 L/kg 1compartment NA NA Human Human +DTXSID1027500 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human +DTXSID1027500 Css NA 0.01642 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027500 Css NA 0.1315 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027500 Css NA 0.01319 mg/L PBTK NA 50% Rat Human +DTXSID1027500 Css NA 0.08647 mg/L PBTK NA 95% Rat Human +DTXSID1027502 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027502 Fup 0.774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027502 Vd NA 0.9478 L/kg 1compartment NA NA Human Human DTXSID1027502 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027502 TK.Half.Life NA 3.344 hours 1compartment NA NA Human Human -DTXSID1027502 Css NA 0.3754 mg/L 3compartmentss NA 50% Human Human -DTXSID1027502 Css NA 2.489 mg/L 3compartmentss NA 95% Human Human -DTXSID1027502 Css NA 0.3254 mg/L PBTK NA 50% Human Human -DTXSID1027502 Css NA 1.627 mg/L PBTK NA 95% Human Human -DTXSID1027502 Clint NA 0.8918 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027502 Fup NA 0.849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027502 Vd NA 0.982 L/kg 1compartment NA NA Rat Human +DTXSID1027502 TK.Half.Life NA 8.076 hours 1compartment NA NA Human Human +DTXSID1027502 Css NA 0.954 mg/L 3compartmentss NA 50% Human Human +DTXSID1027502 Css NA 6.213 mg/L 3compartmentss NA 95% Human Human +DTXSID1027502 Css NA 0.8177 mg/L PBTK NA 50% Human Human +DTXSID1027502 Css NA 4.042 mg/L PBTK NA 95% Human Human +DTXSID1027502 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027502 Fup 0.774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027502 Vd NA 0.9271 L/kg 1compartment NA NA Rat Human DTXSID1027502 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027502 TK.Half.Life NA 1.532 hours 1compartment NA NA Rat Human -DTXSID1027502 Css NA 0.1366 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027502 Css NA 0.8277 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027502 Css NA 0.1176 mg/L PBTK NA 50% Rat Human -DTXSID1027502 Css NA 0.5059 mg/L PBTK NA 95% Rat Human -DTXSID1027506 Clint NA 3.423 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027506 Fup NA 0.0834 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027506 Vd NA 2.469 L/kg 1compartment NA NA Human Human -DTXSID1027506 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID1027506 TK.Half.Life NA 60.43 hours 1compartment NA NA Human Human -DTXSID1027506 Css NA 3.346 mg/L 3compartmentss NA 50% Human Human -DTXSID1027506 Css NA 17.22 mg/L 3compartmentss NA 95% Human Human -DTXSID1027506 Css NA 2.292 mg/L PBTK NA 50% Human Human -DTXSID1027506 Css NA 11.14 mg/L PBTK NA 95% Human Human -DTXSID1027506 Clint NA 3.423 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027506 Fup NA 0.0834 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027506 Vd NA 1.858 L/kg 1compartment NA NA Rat Human -DTXSID1027506 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1027506 TK.Half.Life NA 14.2 hours 1compartment NA NA Rat Human -DTXSID1027506 Css NA 1.711 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027506 Css NA 6.037 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027506 Css NA 1.111 mg/L PBTK NA 50% Rat Human -DTXSID1027506 Css NA 3.683 mg/L PBTK NA 95% Rat Human +DTXSID1027502 TK.Half.Life NA 2.654 hours 1compartment NA NA Rat Human +DTXSID1027502 Css NA 0.05626 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027502 Css NA 0.3498 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027502 Css NA 0.04872 mg/L PBTK NA 50% Rat Human +DTXSID1027502 Css NA 0.2191 mg/L PBTK NA 95% Rat Human +DTXSID1027504 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027504 Fup 0.793 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027504 Vd NA 3.198 L/kg 1compartment NA NA Human Human +DTXSID1027504 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1027504 TK.Half.Life NA 26.53 hours 1compartment NA NA Human Human +DTXSID1027504 Css NA 0.6659 mg/L 3compartmentss NA 50% Human Human +DTXSID1027504 Css NA 5.272 mg/L 3compartmentss NA 95% Human Human +DTXSID1027504 Css NA 0.8 mg/L PBTK NA 50% Human Human +DTXSID1027504 Css NA 3.842 mg/L PBTK NA 95% Human Human +DTXSID1027504 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027504 Fup 0.793 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027504 Vd NA 3.252 L/kg 1compartment NA NA Rat Human +DTXSID1027504 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1027504 TK.Half.Life NA 9.079 hours 1compartment NA NA Rat Human +DTXSID1027504 Css NA 0.03827 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027504 Css NA 0.2922 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027504 Css NA 0.04763 mg/L PBTK NA 50% Rat Human +DTXSID1027504 Css NA 0.2091 mg/L PBTK NA 95% Rat Human +DTXSID1027506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027506 Fup 0.0221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027506 Vd NA 1.701 L/kg 1compartment NA NA Human Human +DTXSID1027506 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1027506 TK.Half.Life NA 15.1 hours 1compartment NA NA Human Human +DTXSID1027506 Css NA 1.342 mg/L 3compartmentss NA 50% Human Human +DTXSID1027506 Css NA 11.78 mg/L 3compartmentss NA 95% Human Human +DTXSID1027506 Css NA 0.8532 mg/L PBTK NA 50% Human Human +DTXSID1027506 Css NA 7.341 mg/L PBTK NA 95% Human Human +DTXSID1027506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027506 Fup 0.0221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027506 Vd NA 1.264 L/kg 1compartment NA NA Rat Human +DTXSID1027506 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1027506 TK.Half.Life NA 5.454 hours 1compartment NA NA Rat Human +DTXSID1027506 Css NA 0.1731 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027506 Css NA 1.18 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027506 Css NA 0.1066 mg/L PBTK NA 50% Rat Human +DTXSID1027506 Css NA 0.704 mg/L PBTK NA 95% Rat Human +DTXSID1027508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027508 Fup 0.00991 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027508 Vd NA 13.53 L/kg 1compartment NA NA Human Human +DTXSID1027508 Days.Css NA 88 Days PBTK NA NA Human Human +DTXSID1027508 TK.Half.Life NA 404.9 hours 1compartment NA NA Human Human +DTXSID1027508 Css NA 0.8852 mg/L 3compartmentss NA 50% Human Human +DTXSID1027508 Css NA 5.839 mg/L 3compartmentss NA 95% Human Human +DTXSID1027508 Css NA 1.33 mg/L PBTK NA 50% Human Human +DTXSID1027508 Css NA 8.28 mg/L PBTK NA 95% Human Human +DTXSID1027508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027508 Fup 0.00991 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027508 Vd NA 10.8 L/kg 1compartment NA NA Rat Human +DTXSID1027508 Days.Css NA 53 Days PBTK NA NA Rat Human +DTXSID1027508 TK.Half.Life NA 57.43 hours 1compartment NA NA Rat Human +DTXSID1027508 Css NA 0.009038 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027508 Css NA 0.0542 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027508 Css NA 0.01388 mg/L PBTK NA 50% Rat Human +DTXSID1027508 Css NA 0.08201 mg/L PBTK NA 95% Rat Human DTXSID1027550 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1027550 Fup NA 0.4809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027550 Vd NA 0.5234 L/kg 1compartment NA NA Human Human +DTXSID1027550 Vd NA 0.5349 L/kg 1compartment NA NA Human Human DTXSID1027550 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027550 TK.Half.Life NA 7.042 hours 1compartment NA NA Human Human -DTXSID1027550 Css NA 1.5 mg/L 3compartmentss NA 50% Human Human -DTXSID1027550 Css NA 7.256 mg/L 3compartmentss NA 95% Human Human -DTXSID1027550 Css NA 1.135 mg/L PBTK NA 50% Human Human -DTXSID1027550 Css NA 4.644 mg/L PBTK NA 95% Human Human +DTXSID1027550 TK.Half.Life NA 7.196 hours 1compartment NA NA Human Human +DTXSID1027550 Css NA 1.267 mg/L 3compartmentss NA 50% Human Human +DTXSID1027550 Css NA 6.496 mg/L 3compartmentss NA 95% Human Human +DTXSID1027550 Css NA 0.9597 mg/L PBTK NA 50% Human Human +DTXSID1027550 Css NA 4.145 mg/L PBTK NA 95% Human Human DTXSID1027550 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1027550 Fup NA 0.4809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027550 Vd NA 0.5373 L/kg 1compartment NA NA Rat Human +DTXSID1027550 Vd NA 0.5481 L/kg 1compartment NA NA Rat Human DTXSID1027550 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027550 TK.Half.Life NA 2.463 hours 1compartment NA NA Rat Human -DTXSID1027550 Css NA 0.4106 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027550 Css NA 1.788 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027550 Css NA 0.2959 mg/L PBTK NA 50% Rat Human -DTXSID1027550 Css NA 1.056 mg/L PBTK NA 95% Rat Human +DTXSID1027550 TK.Half.Life NA 2.512 hours 1compartment NA NA Rat Human +DTXSID1027550 Css NA 0.02361 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027550 Css NA 0.1612 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027550 Css NA 0.01725 mg/L PBTK NA 50% Rat Human +DTXSID1027550 Css NA 0.1043 mg/L PBTK NA 95% Rat Human DTXSID1027556 Clint NA 0.003459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1027556 Fup NA 0.4002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027556 Vd NA 0.3813 L/kg 1compartment NA NA Human Human +DTXSID1027556 Vd NA 0.3191 L/kg 1compartment NA NA Human Human DTXSID1027556 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027556 TK.Half.Life NA 6.129 hours 1compartment NA NA Human Human -DTXSID1027556 Css NA 1.899 mg/L 3compartmentss NA 50% Human Human -DTXSID1027556 Css NA 8.338 mg/L 3compartmentss NA 95% Human Human -DTXSID1027556 Css NA 1.327 mg/L PBTK NA 50% Human Human -DTXSID1027556 Css NA 5.13 mg/L PBTK NA 95% Human Human +DTXSID1027556 TK.Half.Life NA 5.119 hours 1compartment NA NA Human Human +DTXSID1027556 Css NA 1.664 mg/L 3compartmentss NA 50% Human Human +DTXSID1027556 Css NA 7.243 mg/L 3compartmentss NA 95% Human Human +DTXSID1027556 Css NA 1.125 mg/L PBTK NA 50% Human Human +DTXSID1027556 Css NA 4.439 mg/L PBTK NA 95% Human Human DTXSID1027556 Clint NA 0.003459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1027556 Fup NA 0.4002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027556 Vd NA 0.3893 L/kg 1compartment NA NA Rat Human +DTXSID1027556 Vd NA 0.3352 L/kg 1compartment NA NA Rat Human DTXSID1027556 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027556 TK.Half.Life NA 2.138 hours 1compartment NA NA Rat Human -DTXSID1027556 Css NA 0.5312 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027556 Css NA 1.951 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027556 Css NA 0.3502 mg/L PBTK NA 50% Rat Human -DTXSID1027556 Css NA 1.126 mg/L PBTK NA 95% Rat Human -DTXSID1027558 Clint NA 0.8703 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027558 Fup NA 0.37 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027558 Vd NA 0.3774 L/kg 1compartment NA NA Human Human +DTXSID1027556 TK.Half.Life NA 1.84 hours 1compartment NA NA Rat Human +DTXSID1027556 Css NA 0.03054 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027556 Css NA 0.1912 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027556 Css NA 0.01983 mg/L PBTK NA 50% Rat Human +DTXSID1027556 Css NA 0.1147 mg/L PBTK NA 95% Rat Human +DTXSID1027558 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027558 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027558 Vd NA 0.2847 L/kg 1compartment NA NA Human Human DTXSID1027558 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027558 TK.Half.Life NA 2.81 hours 1compartment NA NA Human Human -DTXSID1027558 Css NA 0.8577 mg/L 3compartmentss NA 50% Human Human -DTXSID1027558 Css NA 3.798 mg/L 3compartmentss NA 95% Human Human -DTXSID1027558 Css NA 0.5916 mg/L PBTK NA 50% Human Human -DTXSID1027558 Css NA 2.377 mg/L PBTK NA 95% Human Human -DTXSID1027558 Clint NA 0.8703 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027558 Fup NA 0.37 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027558 Vd NA 0.3809 L/kg 1compartment NA NA Rat Human +DTXSID1027558 TK.Half.Life NA 0.5026 hours 1compartment NA NA Human Human +DTXSID1027558 Css NA 0.1221 mg/L 3compartmentss NA 50% Human Human +DTXSID1027558 Css NA 0.8395 mg/L 3compartmentss NA 95% Human Human +DTXSID1027558 Css NA 0.07698 mg/L PBTK NA 50% Human Human +DTXSID1027558 Css NA 0.5188 mg/L PBTK NA 95% Human Human +DTXSID1027558 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027558 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027558 Vd NA 0.2856 L/kg 1compartment NA NA Rat Human DTXSID1027558 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027558 TK.Half.Life NA 1.358 hours 1compartment NA NA Rat Human -DTXSID1027558 Css NA 0.3424 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027558 Css NA 1.235 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027558 Css NA 0.2239 mg/L PBTK NA 50% Rat Human -DTXSID1027558 Css NA 0.7131 mg/L PBTK NA 95% Rat Human +DTXSID1027558 TK.Half.Life NA 0.2797 hours 1compartment NA NA Rat Human +DTXSID1027558 Css NA 0.01572 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027558 Css NA 0.08078 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027558 Css NA 0.009722 mg/L PBTK NA 50% Rat Human +DTXSID1027558 Css NA 0.04876 mg/L PBTK NA 95% Rat Human DTXSID1027633 Clint NA 60440 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1027633 Fup NA 0.0037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027633 Vd NA 531600 L/kg 1compartment NA NA Human Human -DTXSID1027633 Days.Css NA 1529 Days PBTK NA NA Human Human -DTXSID1027633 TK.Half.Life NA 5771 hours 1compartment NA NA Human Human -DTXSID1027633 Css NA 8e-09 mg/L 3compartmentss NA 50% Human Human -DTXSID1027633 Css NA 5.2e-08 mg/L 3compartmentss NA 95% Human Human -DTXSID1027633 Css NA 0.0008962 mg/L PBTK NA 50% Human Human -DTXSID1027633 Css NA 0.005235 mg/L PBTK NA 95% Human Human +DTXSID1027633 Vd NA 0.1803 L/kg 1compartment NA NA Human Human +DTXSID1027633 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1027633 TK.Half.Life NA 0.1818 hours 1compartment NA NA Human Human +DTXSID1027633 Css NA 0.000854 mg/L 3compartmentss NA 50% Human Human +DTXSID1027633 Css NA 0.0187 mg/L 3compartmentss NA 95% Human Human +DTXSID1027633 Css NA 0.0004976 mg/L PBTK NA 50% Human Human +DTXSID1027633 Css NA 0.01094 mg/L PBTK NA 95% Human Human DTXSID1027633 Clint NA 60440 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1027633 Fup NA 0.0037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027633 Vd NA 507300 L/kg 1compartment NA NA Rat Human -DTXSID1027633 Days.Css NA 1066 Days PBTK NA NA Rat Human -DTXSID1027633 TK.Half.Life NA 1028 hours 1compartment NA NA Rat Human -DTXSID1027633 Css NA 4e-09 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027633 Css NA 1.8e-08 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027633 Css NA 0.0004934 mg/L PBTK NA 50% Rat Human -DTXSID1027633 Css NA 0.002114 mg/L PBTK NA 95% Rat Human +DTXSID1027633 Vd NA 0.1722 L/kg 1compartment NA NA Rat Human +DTXSID1027633 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1027633 TK.Half.Life NA 0.07696 hours 1compartment NA NA Rat Human +DTXSID1027633 Css NA 2.87e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027633 Css NA 0.0009358 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027633 Css NA 1.58e-05 mg/L PBTK NA 50% Rat Human +DTXSID1027633 Css NA 0.0005164 mg/L PBTK NA 95% Rat Human DTXSID1027635 Clint 9.95 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1027635 Fup 9.42e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1027635 Vd NA 0.4993 L/kg 1compartment NA NA Human Human -DTXSID1027635 Days.Css NA 95 Days PBTK NA NA Human Human -DTXSID1027635 TK.Half.Life NA 381.5 hours 1compartment NA NA Human Human -DTXSID1027635 Css NA 5.767 mg/L 3compartmentss NA 50% Human Human -DTXSID1027635 Css NA 44.04 mg/L 3compartmentss NA 95% Human Human -DTXSID1027635 Css NA 3.91 mg/L PBTK NA 50% Human Human -DTXSID1027635 Css NA 28.06 mg/L PBTK NA 95% Human Human +DTXSID1027635 Vd NA 0.4937 L/kg 1compartment NA NA Human Human +DTXSID1027635 Days.Css NA 96 Days PBTK NA NA Human Human +DTXSID1027635 TK.Half.Life NA 382.5 hours 1compartment NA NA Human Human +DTXSID1027635 Css NA 5.446 mg/L 3compartmentss NA 50% Human Human +DTXSID1027635 Css NA 43.01 mg/L 3compartmentss NA 95% Human Human +DTXSID1027635 Css NA 3.698 mg/L PBTK NA 50% Human Human +DTXSID1027635 Css NA 27.49 mg/L PBTK NA 95% Human Human DTXSID1027635 Clint 9.95 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1027635 Fup 9.42e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1027635 Vd NA 0.3702 L/kg 1compartment NA NA Rat Human +DTXSID1027635 Vd NA 0.3665 L/kg 1compartment NA NA Rat Human DTXSID1027635 Days.Css NA 46 Days PBTK NA NA Rat Human -DTXSID1027635 TK.Half.Life NA 196.2 hours 1compartment NA NA Rat Human -DTXSID1027635 Css NA 3.171 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027635 Css NA 21.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027635 Css NA 2.039 mg/L PBTK NA 50% Rat Human -DTXSID1027635 Css NA 13.03 mg/L PBTK NA 95% Rat Human -DTXSID1027639 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027639 Fup NA 0.8032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027639 Vd NA 0.8781 L/kg 1compartment NA NA Human Human +DTXSID1027635 TK.Half.Life NA 196.7 hours 1compartment NA NA Rat Human +DTXSID1027635 Css NA 0.6988 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027635 Css NA 4.607 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027635 Css NA 0.4663 mg/L PBTK NA 50% Rat Human +DTXSID1027635 Css NA 2.894 mg/L PBTK NA 95% Rat Human +DTXSID1027639 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027639 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027639 Vd NA 0.6482 L/kg 1compartment NA NA Human Human DTXSID1027639 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027639 TK.Half.Life NA 7.151 hours 1compartment NA NA Human Human -DTXSID1027639 Css NA 0.9698 mg/L 3compartmentss NA 50% Human Human -DTXSID1027639 Css NA 5.827 mg/L 3compartmentss NA 95% Human Human -DTXSID1027639 Css NA 0.8194 mg/L PBTK NA 50% Human Human -DTXSID1027639 Css NA 3.811 mg/L PBTK NA 95% Human Human -DTXSID1027639 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027639 Fup NA 0.8032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027639 Vd NA 0.8746 L/kg 1compartment NA NA Rat Human +DTXSID1027639 TK.Half.Life NA 6.822 hours 1compartment NA NA Human Human +DTXSID1027639 Css NA 1.179 mg/L 3compartmentss NA 50% Human Human +DTXSID1027639 Css NA 8.133 mg/L 3compartmentss NA 95% Human Human +DTXSID1027639 Css NA 0.9304 mg/L PBTK NA 50% Human Human +DTXSID1027639 Css NA 5.09 mg/L PBTK NA 95% Human Human +DTXSID1027639 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027639 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027639 Vd NA 0.6625 L/kg 1compartment NA NA Rat Human DTXSID1027639 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027639 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human -DTXSID1027639 Css NA 0.2446 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027639 Css NA 1.479 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027639 Css NA 0.2021 mg/L PBTK NA 50% Rat Human -DTXSID1027639 Css NA 0.8943 mg/L PBTK NA 95% Rat Human -DTXSID1027714 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027714 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027714 Vd NA 18.81 L/kg 1compartment NA NA Human Human -DTXSID1027714 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID1027714 TK.Half.Life NA 897900 hours 1compartment NA NA Human Human -DTXSID1027714 Css NA 1837 mg/L 3compartmentss NA 50% Human Human -DTXSID1027714 Css NA 4542 mg/L 3compartmentss NA 95% Human Human -DTXSID1027714 Css NA 3690 mg/L PBTK NA 50% Human Human -DTXSID1027714 Css NA 7910 mg/L PBTK NA 95% Human Human -DTXSID1027714 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027714 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027714 Vd NA 15.22 L/kg 1compartment NA NA Rat Human -DTXSID1027714 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID1027714 TK.Half.Life NA 61070 hours 1compartment NA NA Rat Human -DTXSID1027714 Css NA 471.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027714 Css NA 778.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027714 Css NA 988.3 mg/L PBTK NA 50% Rat Human -DTXSID1027714 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID1027716 Clint NA 2686 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027716 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027716 Vd NA 530200 L/kg 1compartment NA NA Human Human -DTXSID1027716 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID1027716 TK.Half.Life NA 129800 hours 1compartment NA NA Human Human -DTXSID1027716 Css NA 1.9e-07 mg/L 3compartmentss NA 50% Human Human -DTXSID1027716 Css NA 1.161e-06 mg/L 3compartmentss NA 95% Human Human -DTXSID1027716 Css NA 0.02041 mg/L PBTK NA 50% Human Human -DTXSID1027716 Css NA 0.1194 mg/L PBTK NA 95% Human Human -DTXSID1027716 Clint NA 2686 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027716 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027716 Vd NA 506000 L/kg 1compartment NA NA Rat Human -DTXSID1027716 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID1027716 TK.Half.Life NA 23240 hours 1compartment NA NA Rat Human -DTXSID1027716 Css NA 9.7e-08 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027716 Css NA 4.11e-07 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027716 Css NA 0.01111 mg/L PBTK NA 50% Rat Human -DTXSID1027716 Css NA 0.04717 mg/L PBTK NA 95% Rat Human -DTXSID1027764 Clint NA 1.865 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027764 Fup NA 0.101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027764 Vd NA 1.734 L/kg 1compartment NA NA Human Human -DTXSID1027764 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID1027764 TK.Half.Life NA 36.93 hours 1compartment NA NA Human Human -DTXSID1027764 Css NA 3.062 mg/L 3compartmentss NA 50% Human Human -DTXSID1027764 Css NA 15 mg/L 3compartmentss NA 95% Human Human -DTXSID1027764 Css NA 2.057 mg/L PBTK NA 50% Human Human -DTXSID1027764 Css NA 9.37 mg/L PBTK NA 95% Human Human -DTXSID1027764 Clint NA 1.865 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027764 Fup NA 0.101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027764 Vd NA 1.32 L/kg 1compartment NA NA Rat Human -DTXSID1027764 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1027764 TK.Half.Life NA 11.67 hours 1compartment NA NA Rat Human -DTXSID1027764 Css NA 1.423 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027764 Css NA 5.452 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027764 Css NA 0.9094 mg/L PBTK NA 50% Rat Human -DTXSID1027764 Css NA 3.129 mg/L PBTK NA 95% Rat Human +DTXSID1027639 TK.Half.Life NA 2.372 hours 1compartment NA NA Rat Human +DTXSID1027639 Css NA 0.07203 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027639 Css NA 0.4707 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027639 Css NA 0.05649 mg/L PBTK NA 50% Rat Human +DTXSID1027639 Css NA 0.2844 mg/L PBTK NA 95% Rat Human +DTXSID1027764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027764 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027764 Vd NA 2.744 L/kg 1compartment NA NA Human Human +DTXSID1027764 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1027764 TK.Half.Life NA 12.77 hours 1compartment NA NA Human Human +DTXSID1027764 Css NA 0.4941 mg/L 3compartmentss NA 50% Human Human +DTXSID1027764 Css NA 3.343 mg/L 3compartmentss NA 95% Human Human +DTXSID1027764 Css NA 0.3459 mg/L PBTK NA 50% Human Human +DTXSID1027764 Css NA 2.228 mg/L PBTK NA 95% Human Human +DTXSID1027764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027764 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027764 Vd NA 2.07 L/kg 1compartment NA NA Rat Human +DTXSID1027764 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1027764 TK.Half.Life NA 2.886 hours 1compartment NA NA Rat Human +DTXSID1027764 Css NA 0.06328 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027764 Css NA 0.3273 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027764 Css NA 0.04424 mg/L PBTK NA 50% Rat Human +DTXSID1027764 Css NA 0.2214 mg/L PBTK NA 95% Rat Human DTXSID1027768 Clint NA 0.007305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1027768 Fup NA 0.3914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027768 Vd NA 0.4229 L/kg 1compartment NA NA Human Human +DTXSID1027768 Vd NA 0.3531 L/kg 1compartment NA NA Human Human DTXSID1027768 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027768 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human -DTXSID1027768 Css NA 1.879 mg/L 3compartmentss NA 50% Human Human -DTXSID1027768 Css NA 8.257 mg/L 3compartmentss NA 95% Human Human -DTXSID1027768 Css NA 1.346 mg/L PBTK NA 50% Human Human -DTXSID1027768 Css NA 5.212 mg/L PBTK NA 95% Human Human +DTXSID1027768 TK.Half.Life NA 5.738 hours 1compartment NA NA Human Human +DTXSID1027768 Css NA 1.63 mg/L 3compartmentss NA 50% Human Human +DTXSID1027768 Css NA 7.207 mg/L 3compartmentss NA 95% Human Human +DTXSID1027768 Css NA 1.124 mg/L PBTK NA 50% Human Human +DTXSID1027768 Css NA 4.434 mg/L PBTK NA 95% Human Human DTXSID1027768 Clint NA 0.007305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1027768 Fup NA 0.3914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027768 Vd NA 0.4323 L/kg 1compartment NA NA Rat Human +DTXSID1027768 Vd NA 0.3708 L/kg 1compartment NA NA Rat Human DTXSID1027768 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027768 TK.Half.Life NA 2.42 hours 1compartment NA NA Rat Human -DTXSID1027768 Css NA 0.5266 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027768 Css NA 1.908 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027768 Css NA 0.3558 mg/L PBTK NA 50% Rat Human -DTXSID1027768 Css NA 1.113 mg/L PBTK NA 95% Rat Human -DTXSID1027841 Clint NA 19.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027841 Fup NA 0.1241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027841 Vd NA 2.831 L/kg 1compartment NA NA Human Human -DTXSID1027841 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1027841 TK.Half.Life NA 17.52 hours 1compartment NA NA Human Human -DTXSID1027841 Css NA 0.7074 mg/L 3compartmentss NA 50% Human Human -DTXSID1027841 Css NA 4.464 mg/L 3compartmentss NA 95% Human Human -DTXSID1027841 Css NA 0.4938 mg/L PBTK NA 50% Human Human -DTXSID1027841 Css NA 2.984 mg/L PBTK NA 95% Human Human -DTXSID1027841 Clint NA 19.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027841 Fup NA 0.1241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027841 Vd NA 2.133 L/kg 1compartment NA NA Rat Human -DTXSID1027841 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027841 TK.Half.Life NA 3.603 hours 1compartment NA NA Rat Human -DTXSID1027841 Css NA 0.3904 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027841 Css NA 1.97 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027841 Css NA 0.2614 mg/L PBTK NA 50% Rat Human -DTXSID1027841 Css NA 1.266 mg/L PBTK NA 95% Rat Human -DTXSID1027891 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027891 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027891 Vd NA 0.5326 L/kg 1compartment NA NA Human Human -DTXSID1027891 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027891 TK.Half.Life NA 9.524 hours 1compartment NA NA Human Human -DTXSID1027891 Css NA 3.125 mg/L 3compartmentss NA 50% Human Human -DTXSID1027891 Css NA 32.01 mg/L 3compartmentss NA 95% Human Human -DTXSID1027891 Css NA 1.898 mg/L PBTK NA 50% Human Human -DTXSID1027891 Css NA 18.94 mg/L PBTK NA 95% Human Human -DTXSID1027891 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027891 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027891 Vd NA 0.4356 L/kg 1compartment NA NA Rat Human -DTXSID1027891 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027891 TK.Half.Life NA 5.154 hours 1compartment NA NA Rat Human -DTXSID1027891 Css NA 1.819 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027891 Css NA 15.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027891 Css NA 1.034 mg/L PBTK NA 50% Rat Human -DTXSID1027891 Css NA 8.561 mg/L PBTK NA 95% Rat Human -DTXSID1027899 Clint NA 0.8636 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027899 Fup NA 0.1941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027899 Vd NA 0.3669 L/kg 1compartment NA NA Human Human -DTXSID1027899 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027899 TK.Half.Life NA 4.983 hours 1compartment NA NA Human Human -DTXSID1027899 Css NA 1.654 mg/L 3compartmentss NA 50% Human Human -DTXSID1027899 Css NA 6.768 mg/L 3compartmentss NA 95% Human Human -DTXSID1027899 Css NA 1.084 mg/L PBTK NA 50% Human Human -DTXSID1027899 Css NA 4.155 mg/L PBTK NA 95% Human Human -DTXSID1027899 Clint NA 0.8636 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027899 Fup NA 0.1941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027899 Vd NA 0.3738 L/kg 1compartment NA NA Rat Human -DTXSID1027899 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027899 TK.Half.Life NA 2.475 hours 1compartment NA NA Rat Human -DTXSID1027899 Css NA 0.6628 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027899 Css NA 2.132 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027899 Css NA 0.4139 mg/L PBTK NA 50% Rat Human -DTXSID1027899 Css NA 1.217 mg/L PBTK NA 95% Rat Human -DTXSID1027920 Clint NA 70.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027920 Fup NA 0.0182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027920 Vd NA 2.281 L/kg 1compartment NA NA Human Human +DTXSID1027768 TK.Half.Life NA 2.071 hours 1compartment NA NA Rat Human +DTXSID1027768 Css NA 0.0303 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027768 Css NA 0.1886 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027768 Css NA 0.01999 mg/L PBTK NA 50% Rat Human +DTXSID1027768 Css NA 0.1146 mg/L PBTK NA 95% Rat Human +DTXSID1027920 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027920 Fup 0.0403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027920 Vd NA 1.382 L/kg 1compartment NA NA Human Human DTXSID1027920 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027920 TK.Half.Life NA 1.899 hours 1compartment NA NA Human Human -DTXSID1027920 Css NA 0.01812 mg/L 3compartmentss NA 50% Human Human -DTXSID1027920 Css NA 0.2002 mg/L 3compartmentss NA 95% Human Human -DTXSID1027920 Css NA 0.01375 mg/L PBTK NA 50% Human Human -DTXSID1027920 Css NA 0.135 mg/L PBTK NA 95% Human Human -DTXSID1027920 Clint NA 70.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027920 Fup NA 0.0182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027920 Vd NA 2.014 L/kg 1compartment NA NA Rat Human +DTXSID1027920 TK.Half.Life NA 3.743 hours 1compartment NA NA Human Human +DTXSID1027920 Css NA 0.302 mg/L 3compartmentss NA 50% Human Human +DTXSID1027920 Css NA 3.417 mg/L 3compartmentss NA 95% Human Human +DTXSID1027920 Css NA 0.217 mg/L PBTK NA 50% Human Human +DTXSID1027920 Css NA 2.185 mg/L PBTK NA 95% Human Human +DTXSID1027920 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027920 Fup 0.0403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027920 Vd NA 1.347 L/kg 1compartment NA NA Rat Human DTXSID1027920 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027920 TK.Half.Life NA 0.7662 hours 1compartment NA NA Rat Human -DTXSID1027920 Css NA 0.01014 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027920 Css NA 0.09523 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027920 Css NA 0.007392 mg/L PBTK NA 50% Rat Human -DTXSID1027920 Css NA 0.0597 mg/L PBTK NA 95% Rat Human -DTXSID1027924 Clint NA 358.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027924 Fup NA 0.0063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027924 Vd NA 979.1 L/kg 1compartment NA NA Human Human -DTXSID1027924 Days.Css NA 441 Days PBTK NA NA Human Human -DTXSID1027924 TK.Half.Life NA 1767 hours 1compartment NA NA Human Human -DTXSID1027924 Css NA 0.0009694 mg/L 3compartmentss NA 50% Human Human -DTXSID1027924 Css NA 0.006058 mg/L 3compartmentss NA 95% Human Human -DTXSID1027924 Css NA 0.1495 mg/L PBTK NA 50% Human Human -DTXSID1027924 Css NA 0.8431 mg/L PBTK NA 95% Human Human -DTXSID1027924 Clint NA 358.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027924 Fup NA 0.0063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027924 Vd NA 896.7 L/kg 1compartment NA NA Rat Human -DTXSID1027924 Days.Css NA 305 Days PBTK NA NA Rat Human -DTXSID1027924 TK.Half.Life NA 290.1 hours 1compartment NA NA Rat Human -DTXSID1027924 Css NA 0.0004893 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027924 Css NA 0.002191 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027924 Css NA 0.08185 mg/L PBTK NA 50% Rat Human -DTXSID1027924 Css NA 0.3585 mg/L PBTK NA 95% Rat Human -DTXSID1027926 Clint NA 92.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027926 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027926 Vd NA 49.4 L/kg 1compartment NA NA Human Human -DTXSID1027926 Days.Css NA 72 Days PBTK NA NA Human Human -DTXSID1027926 TK.Half.Life NA 347.6 hours 1compartment NA NA Human Human -DTXSID1027926 Css NA 0.1059 mg/L 3compartmentss NA 50% Human Human -DTXSID1027926 Css NA 0.6394 mg/L 3compartmentss NA 95% Human Human -DTXSID1027926 Css NA 0.5784 mg/L PBTK NA 50% Human Human -DTXSID1027926 Css NA 3.258 mg/L PBTK NA 95% Human Human -DTXSID1027926 Clint NA 92.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027926 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027926 Vd NA 41.62 L/kg 1compartment NA NA Rat Human -DTXSID1027926 Days.Css NA 47 Days PBTK NA NA Rat Human -DTXSID1027926 TK.Half.Life NA 52.19 hours 1compartment NA NA Rat Human -DTXSID1027926 Css NA 0.05449 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027926 Css NA 0.2363 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027926 Css NA 0.3132 mg/L PBTK NA 50% Rat Human -DTXSID1027926 Css NA 1.326 mg/L PBTK NA 95% Rat Human -DTXSID1027970 Clint NA 1.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027970 Fup NA 0.2054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027970 Vd NA 2.356 L/kg 1compartment NA NA Human Human -DTXSID1027970 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID1027970 TK.Half.Life NA 50.78 hours 1compartment NA NA Human Human -DTXSID1027970 Css NA 2.464 mg/L 3compartmentss NA 50% Human Human -DTXSID1027970 Css NA 9.181 mg/L 3compartmentss NA 95% Human Human -DTXSID1027970 Css NA 1.796 mg/L PBTK NA 50% Human Human -DTXSID1027970 Css NA 6.199 mg/L PBTK NA 95% Human Human -DTXSID1027970 Clint NA 1.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027970 Fup NA 0.2054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027970 Vd NA 1.797 L/kg 1compartment NA NA Rat Human -DTXSID1027970 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1027970 TK.Half.Life NA 11.54 hours 1compartment NA NA Rat Human -DTXSID1027970 Css NA 1.068 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027970 Css NA 2.982 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027970 Css NA 0.7455 mg/L PBTK NA 50% Rat Human -DTXSID1027970 Css NA 1.853 mg/L PBTK NA 95% Rat Human -DTXSID1027978 Clint NA 152.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027978 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1027978 Vd NA 1.937 L/kg 1compartment NA NA Human Human +DTXSID1027920 TK.Half.Life NA 2.249 hours 1compartment NA NA Rat Human +DTXSID1027920 Css NA 0.04073 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027920 Css NA 0.3613 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027920 Css NA 0.02868 mg/L PBTK NA 50% Rat Human +DTXSID1027920 Css NA 0.2204 mg/L PBTK NA 95% Rat Human +DTXSID1027970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027970 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027970 Vd NA 1.323 L/kg 1compartment NA NA Human Human +DTXSID1027970 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1027970 TK.Half.Life NA 1.816 hours 1compartment NA NA Human Human +DTXSID1027970 Css NA 0.07546 mg/L 3compartmentss NA 50% Human Human +DTXSID1027970 Css NA 0.5716 mg/L 3compartmentss NA 95% Human Human +DTXSID1027970 Css NA 0.0557 mg/L PBTK NA 50% Human Human +DTXSID1027970 Css NA 0.3865 mg/L PBTK NA 95% Human Human +DTXSID1027970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027970 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027970 Vd NA 1.077 L/kg 1compartment NA NA Rat Human +DTXSID1027970 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1027970 TK.Half.Life NA 0.7398 hours 1compartment NA NA Rat Human +DTXSID1027970 Css NA 0.009445 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027970 Css NA 0.05493 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027970 Css NA 0.007012 mg/L PBTK NA 50% Rat Human +DTXSID1027970 Css NA 0.03742 mg/L PBTK NA 95% Rat Human +DTXSID1027978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027978 Fup 0.0898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1027978 Vd NA 1.651 L/kg 1compartment NA NA Human Human DTXSID1027978 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1027978 TK.Half.Life NA 2.937 hours 1compartment NA NA Human Human -DTXSID1027978 Css NA 0.106 mg/L 3compartmentss NA 50% Human Human -DTXSID1027978 Css NA 0.8805 mg/L 3compartmentss NA 95% Human Human -DTXSID1027978 Css NA 0.06915 mg/L PBTK NA 50% Human Human -DTXSID1027978 Css NA 0.5551 mg/L PBTK NA 95% Human Human -DTXSID1027978 Clint NA 152.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027978 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1027978 Vd NA 1.451 L/kg 1compartment NA NA Rat Human +DTXSID1027978 TK.Half.Life NA 5.259 hours 1compartment NA NA Human Human +DTXSID1027978 Css NA 0.3566 mg/L 3compartmentss NA 50% Human Human +DTXSID1027978 Css NA 2.591 mg/L 3compartmentss NA 95% Human Human +DTXSID1027978 Css NA 0.2363 mg/L PBTK NA 50% Human Human +DTXSID1027978 Css NA 1.62 mg/L PBTK NA 95% Human Human +DTXSID1027978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027978 Fup 0.0898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1027978 Vd NA 1.255 L/kg 1compartment NA NA Rat Human DTXSID1027978 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1027978 TK.Half.Life NA 0.9793 hours 1compartment NA NA Rat Human -DTXSID1027978 Css NA 0.06034 mg/L 3compartmentss NA 50% Rat Human -DTXSID1027978 Css NA 0.389 mg/L 3compartmentss NA 95% Rat Human -DTXSID1027978 Css NA 0.03724 mg/L PBTK NA 50% Rat Human -DTXSID1027978 Css NA 0.2292 mg/L PBTK NA 95% Rat Human -DTXSID1029120 Clint NA 6.853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029120 Fup NA 0.0796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029120 Vd NA 1.888 L/kg 1compartment NA NA Human Human -DTXSID1029120 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1029120 TK.Half.Life NA 18.16 hours 1compartment NA NA Human Human -DTXSID1029120 Css NA 1.364 mg/L 3compartmentss NA 50% Human Human -DTXSID1029120 Css NA 8.551 mg/L 3compartmentss NA 95% Human Human -DTXSID1029120 Css NA 0.9015 mg/L PBTK NA 50% Human Human -DTXSID1029120 Css NA 5.4 mg/L PBTK NA 95% Human Human -DTXSID1029120 Clint NA 6.853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029120 Fup NA 0.0796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029120 Vd NA 1.426 L/kg 1compartment NA NA Rat Human +DTXSID1027978 TK.Half.Life NA 1.953 hours 1compartment NA NA Rat Human +DTXSID1027978 Css NA 0.04634 mg/L 3compartmentss NA 50% Rat Human +DTXSID1027978 Css NA 0.2687 mg/L 3compartmentss NA 95% Rat Human +DTXSID1027978 Css NA 0.02998 mg/L PBTK NA 50% Rat Human +DTXSID1027978 Css NA 0.1639 mg/L PBTK NA 95% Rat Human +DTXSID10282052 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10282052 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10282052 Vd NA 2.745 L/kg 1compartment NA NA Human Human +DTXSID10282052 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID10282052 TK.Half.Life NA 47.64 hours 1compartment NA NA Human Human +DTXSID10282052 Css NA 2.33 mg/L 3compartmentss NA 50% Human Human +DTXSID10282052 Css NA 16.61 mg/L 3compartmentss NA 95% Human Human +DTXSID10282052 Css NA 1.569 mg/L PBTK NA 50% Human Human +DTXSID10282052 Css NA 10.49 mg/L PBTK NA 95% Human Human +DTXSID10282052 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10282052 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10282052 Vd NA 2.051 L/kg 1compartment NA NA Rat Human +DTXSID10282052 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID10282052 TK.Half.Life NA 9.743 hours 1compartment NA NA Rat Human +DTXSID10282052 Css NA 0.3008 mg/L 3compartmentss NA 50% Rat Human +DTXSID10282052 Css NA 1.85 mg/L 3compartmentss NA 95% Rat Human +DTXSID10282052 Css NA 0.1985 mg/L PBTK NA 50% Rat Human +DTXSID10282052 Css NA 1.173 mg/L PBTK NA 95% Rat Human +DTXSID10288059 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10288059 Fup 0.0214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10288059 Vd NA 3.052 L/kg 1compartment NA NA Human Human +DTXSID10288059 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID10288059 TK.Half.Life NA 68.16 hours 1compartment NA NA Human Human +DTXSID10288059 Css NA 2.724 mg/L 3compartmentss NA 50% Human Human +DTXSID10288059 Css NA 17.42 mg/L 3compartmentss NA 95% Human Human +DTXSID10288059 Css NA 1.874 mg/L PBTK NA 50% Human Human +DTXSID10288059 Css NA 11.72 mg/L PBTK NA 95% Human Human +DTXSID10288059 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10288059 Fup 0.0214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10288059 Vd NA 2.285 L/kg 1compartment NA NA Rat Human +DTXSID10288059 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID10288059 TK.Half.Life NA 10.15 hours 1compartment NA NA Rat Human +DTXSID10288059 Css NA 0.3515 mg/L 3compartmentss NA 50% Rat Human +DTXSID10288059 Css NA 2.009 mg/L 3compartmentss NA 95% Rat Human +DTXSID10288059 Css NA 0.2387 mg/L PBTK NA 50% Rat Human +DTXSID10288059 Css NA 1.318 mg/L PBTK NA 95% Rat Human +DTXSID10289223 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10289223 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10289223 Vd NA 0.6097 L/kg 1compartment NA NA Human Human +DTXSID10289223 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID10289223 TK.Half.Life NA 16.69 hours 1compartment NA NA Human Human +DTXSID10289223 Css NA 2.811 mg/L 3compartmentss NA 50% Human Human +DTXSID10289223 Css NA 11.21 mg/L 3compartmentss NA 95% Human Human +DTXSID10289223 Css NA 2.149 mg/L PBTK NA 50% Human Human +DTXSID10289223 Css NA 7.329 mg/L PBTK NA 95% Human Human +DTXSID10289223 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10289223 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10289223 Vd NA 0.5979 L/kg 1compartment NA NA Rat Human +DTXSID10289223 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10289223 TK.Half.Life NA 5.567 hours 1compartment NA NA Rat Human +DTXSID10289223 Css NA 0.1815 mg/L 3compartmentss NA 50% Rat Human +DTXSID10289223 Css NA 0.6031 mg/L 3compartmentss NA 95% Rat Human +DTXSID10289223 Css NA 0.1376 mg/L PBTK NA 50% Rat Human +DTXSID10289223 Css NA 0.3808 mg/L PBTK NA 95% Rat Human +DTXSID1029120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029120 Fup 0.0415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029120 Vd NA 0.9658 L/kg 1compartment NA NA Human Human +DTXSID1029120 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1029120 TK.Half.Life NA 4.824 hours 1compartment NA NA Human Human +DTXSID1029120 Css NA 0.741 mg/L 3compartmentss NA 50% Human Human +DTXSID1029120 Css NA 6.449 mg/L 3compartmentss NA 95% Human Human +DTXSID1029120 Css NA 0.4568 mg/L PBTK NA 50% Human Human +DTXSID1029120 Css NA 3.868 mg/L PBTK NA 95% Human Human +DTXSID1029120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029120 Fup 0.0415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029120 Vd NA 0.7341 L/kg 1compartment NA NA Rat Human DTXSID1029120 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029120 TK.Half.Life NA 6.043 hours 1compartment NA NA Rat Human -DTXSID1029120 Css NA 0.722 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029120 Css NA 3.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029120 Css NA 0.4542 mg/L PBTK NA 50% Rat Human -DTXSID1029120 Css NA 1.948 mg/L PBTK NA 95% Rat Human -DTXSID1029122 Clint NA 31.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029122 Fup NA 0.0932 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029122 Vd NA 0.9381 L/kg 1compartment NA NA Human Human +DTXSID1029120 TK.Half.Life NA 2.133 hours 1compartment NA NA Rat Human +DTXSID1029120 Css NA 0.09696 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029120 Css NA 0.6858 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029120 Css NA 0.05811 mg/L PBTK NA 50% Rat Human +DTXSID1029120 Css NA 0.393 mg/L PBTK NA 95% Rat Human +DTXSID1029122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029122 Fup 0.0746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029122 Vd NA 0.8357 L/kg 1compartment NA NA Human Human DTXSID1029122 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1029122 TK.Half.Life NA 2.028 hours 1compartment NA NA Human Human -DTXSID1029122 Css NA 0.2206 mg/L 3compartmentss NA 50% Human Human -DTXSID1029122 Css NA 1.752 mg/L 3compartmentss NA 95% Human Human -DTXSID1029122 Css NA 0.1405 mg/L PBTK NA 50% Human Human -DTXSID1029122 Css NA 1.079 mg/L PBTK NA 95% Human Human -DTXSID1029122 Clint NA 31.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029122 Fup NA 0.0932 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029122 Vd NA 0.7401 L/kg 1compartment NA NA Rat Human +DTXSID1029122 TK.Half.Life NA 2.666 hours 1compartment NA NA Human Human +DTXSID1029122 Css NA 0.3856 mg/L 3compartmentss NA 50% Human Human +DTXSID1029122 Css NA 2.98 mg/L 3compartmentss NA 95% Human Human +DTXSID1029122 Css NA 0.2443 mg/L PBTK NA 50% Human Human +DTXSID1029122 Css NA 1.795 mg/L PBTK NA 95% Human Human +DTXSID1029122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029122 Fup 0.0746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029122 Vd NA 0.6588 L/kg 1compartment NA NA Rat Human DTXSID1029122 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029122 TK.Half.Life NA 0.8805 hours 1compartment NA NA Rat Human -DTXSID1029122 Css NA 0.1236 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029122 Css NA 0.7488 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029122 Css NA 0.0745 mg/L PBTK NA 50% Rat Human -DTXSID1029122 Css NA 0.4349 mg/L PBTK NA 95% Rat Human -DTXSID1029128 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029128 Fup NA 0.9075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029128 Vd NA 0.8878 L/kg 1compartment NA NA Human Human +DTXSID1029122 TK.Half.Life NA 1.216 hours 1compartment NA NA Rat Human +DTXSID1029122 Css NA 0.05059 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029122 Css NA 0.2976 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029122 Css NA 0.03112 mg/L PBTK NA 50% Rat Human +DTXSID1029122 Css NA 0.1742 mg/L PBTK NA 95% Rat Human +DTXSID1029128 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029128 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029128 Vd NA 0.8287 L/kg 1compartment NA NA Human Human DTXSID1029128 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1029128 TK.Half.Life NA 6.371 hours 1compartment NA NA Human Human -DTXSID1029128 Css NA 0.9042 mg/L 3compartmentss NA 50% Human Human -DTXSID1029128 Css NA 5.161 mg/L 3compartmentss NA 95% Human Human -DTXSID1029128 Css NA 0.771 mg/L PBTK NA 50% Human Human -DTXSID1029128 Css NA 3.379 mg/L PBTK NA 95% Human Human -DTXSID1029128 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029128 Fup NA 0.9075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029128 Vd NA 0.9001 L/kg 1compartment NA NA Rat Human +DTXSID1029128 TK.Half.Life NA 7.681 hours 1compartment NA NA Human Human +DTXSID1029128 Css NA 0.901 mg/L 3compartmentss NA 50% Human Human +DTXSID1029128 Css NA 6.088 mg/L 3compartmentss NA 95% Human Human +DTXSID1029128 Css NA 0.7514 mg/L PBTK NA 50% Human Human +DTXSID1029128 Css NA 3.938 mg/L PBTK NA 95% Human Human +DTXSID1029128 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029128 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029128 Vd NA 0.8248 L/kg 1compartment NA NA Rat Human DTXSID1029128 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029128 TK.Half.Life NA 2.19 hours 1compartment NA NA Rat Human -DTXSID1029128 Css NA 0.2289 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029128 Css NA 1.292 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029128 Css NA 0.1909 mg/L PBTK NA 50% Rat Human -DTXSID1029128 Css NA 0.7898 mg/L PBTK NA 95% Rat Human -DTXSID1029170 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029170 Fup NA 0.8916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029170 Vd NA 1.321 L/kg 1compartment NA NA Human Human -DTXSID1029170 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1029170 TK.Half.Life NA 10.3 hours 1compartment NA NA Human Human -DTXSID1029170 Css NA 0.8572 mg/L 3compartmentss NA 50% Human Human -DTXSID1029170 Css NA 4.829 mg/L 3compartmentss NA 95% Human Human -DTXSID1029170 Css NA 0.7889 mg/L PBTK NA 50% Human Human -DTXSID1029170 Css NA 3.332 mg/L PBTK NA 95% Human Human -DTXSID1029170 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029170 Fup NA 0.8916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029170 Vd NA 1.229 L/kg 1compartment NA NA Rat Human -DTXSID1029170 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029170 TK.Half.Life NA 3.093 hours 1compartment NA NA Rat Human -DTXSID1029170 Css NA 0.2172 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029170 Css NA 1.345 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029170 Css NA 0.1961 mg/L PBTK NA 50% Rat Human -DTXSID1029170 Css NA 0.8404 mg/L PBTK NA 95% Rat Human +DTXSID1029128 TK.Half.Life NA 2.585 hours 1compartment NA NA Rat Human +DTXSID1029128 Css NA 0.01742 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029128 Css NA 0.1381 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029128 Css NA 0.01389 mg/L PBTK NA 50% Rat Human +DTXSID1029128 Css NA 0.08861 mg/L PBTK NA 95% Rat Human DTXSID1029201 Clint NA 3.769 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1029201 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029201 Vd NA 0.2234 L/kg 1compartment NA NA Human Human +DTXSID1029201 Vd NA 0.2174 L/kg 1compartment NA NA Human Human DTXSID1029201 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1029201 TK.Half.Life NA 1.97 hours 1compartment NA NA Human Human -DTXSID1029201 Css NA 1.398 mg/L 3compartmentss NA 50% Human Human -DTXSID1029201 Css NA 8.757 mg/L 3compartmentss NA 95% Human Human -DTXSID1029201 Css NA 0.8405 mg/L PBTK NA 50% Human Human -DTXSID1029201 Css NA 5.133 mg/L PBTK NA 95% Human Human +DTXSID1029201 TK.Half.Life NA 1.837 hours 1compartment NA NA Human Human +DTXSID1029201 Css NA 1.289 mg/L 3compartmentss NA 50% Human Human +DTXSID1029201 Css NA 8.264 mg/L 3compartmentss NA 95% Human Human +DTXSID1029201 Css NA 0.7784 mg/L PBTK NA 50% Human Human +DTXSID1029201 Css NA 4.87 mg/L PBTK NA 95% Human Human DTXSID1029201 Clint NA 3.769 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1029201 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029201 Vd NA 0.2262 L/kg 1compartment NA NA Rat Human +DTXSID1029201 Vd NA 0.221 L/kg 1compartment NA NA Rat Human DTXSID1029201 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029201 TK.Half.Life NA 1.185 hours 1compartment NA NA Rat Human -DTXSID1029201 Css NA 0.7014 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029201 Css NA 3.218 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029201 Css NA 0.3976 mg/L PBTK NA 50% Rat Human -DTXSID1029201 Css NA 1.778 mg/L PBTK NA 95% Rat Human -DTXSID1029203 Clint NA 1.179 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029203 Fup NA 0.5748 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029203 Vd NA 2.71 L/kg 1compartment NA NA Human Human -DTXSID1029203 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1029203 TK.Half.Life NA 10.95 hours 1compartment NA NA Human Human -DTXSID1029203 Css NA 0.3178 mg/L 3compartmentss NA 50% Human Human -DTXSID1029203 Css NA 2.846 mg/L 3compartmentss NA 95% Human Human -DTXSID1029203 Css NA 0.3505 mg/L PBTK NA 50% Human Human -DTXSID1029203 Css NA 2.014 mg/L PBTK NA 95% Human Human -DTXSID1029203 Clint NA 1.179 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029203 Fup NA 0.5748 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029203 Vd NA 2.735 L/kg 1compartment NA NA Rat Human -DTXSID1029203 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029203 TK.Half.Life NA 5.479 hours 1compartment NA NA Rat Human -DTXSID1029203 Css NA 0.1252 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029203 Css NA 1.023 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029203 Css NA 0.1362 mg/L PBTK NA 50% Rat Human -DTXSID1029203 Css NA 0.6782 mg/L PBTK NA 95% Rat Human -DTXSID1029207 Clint NA 0.9538 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029207 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029207 Vd NA 1.434 L/kg 1compartment NA NA Human Human +DTXSID1029201 TK.Half.Life NA 1.114 hours 1compartment NA NA Rat Human +DTXSID1029201 Css NA 0.152 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029201 Css NA 0.7097 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029201 Css NA 0.08878 mg/L PBTK NA 50% Rat Human +DTXSID1029201 Css NA 0.4028 mg/L PBTK NA 95% Rat Human +DTXSID1029207 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029207 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029207 Vd NA 0.8964 L/kg 1compartment NA NA Human Human DTXSID1029207 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1029207 TK.Half.Life NA 4.158 hours 1compartment NA NA Human Human -DTXSID1029207 Css NA 0.2882 mg/L 3compartmentss NA 50% Human Human -DTXSID1029207 Css NA 2.12 mg/L 3compartmentss NA 95% Human Human -DTXSID1029207 Css NA 0.2738 mg/L PBTK NA 50% Human Human -DTXSID1029207 Css NA 1.464 mg/L PBTK NA 95% Human Human -DTXSID1029207 Clint NA 0.9538 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029207 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029207 Vd NA 1.329 L/kg 1compartment NA NA Rat Human +DTXSID1029207 TK.Half.Life NA 0.8582 hours 1compartment NA NA Human Human +DTXSID1029207 Css NA 0.03634 mg/L 3compartmentss NA 50% Human Human +DTXSID1029207 Css NA 0.3492 mg/L 3compartmentss NA 95% Human Human +DTXSID1029207 Css NA 0.02919 mg/L PBTK NA 50% Human Human +DTXSID1029207 Css NA 0.2444 mg/L PBTK NA 95% Human Human +DTXSID1029207 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029207 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029207 Vd NA 0.8416 L/kg 1compartment NA NA Rat Human DTXSID1029207 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029207 TK.Half.Life NA 1.738 hours 1compartment NA NA Rat Human -DTXSID1029207 Css NA 0.1072 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029207 Css NA 0.7218 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029207 Css NA 0.1012 mg/L PBTK NA 50% Rat Human -DTXSID1029207 Css NA 0.4544 mg/L PBTK NA 95% Rat Human -DTXSID1029251 Clint NA 0.008954 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029251 Fup NA 0.5532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029251 Vd NA 0.3858 L/kg 1compartment NA NA Human Human +DTXSID1029207 TK.Half.Life NA 0.4032 hours 1compartment NA NA Rat Human +DTXSID1029207 Css NA 0.00444 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029207 Css NA 0.03571 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029207 Css NA 0.003611 mg/L PBTK NA 50% Rat Human +DTXSID1029207 Css NA 0.02394 mg/L PBTK NA 95% Rat Human +DTXSID1029251 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029251 Fup 0.844 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029251 Vd NA 0.4917 L/kg 1compartment NA NA Human Human DTXSID1029251 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1029251 TK.Half.Life NA 4.443 hours 1compartment NA NA Human Human -DTXSID1029251 Css NA 1.429 mg/L 3compartmentss NA 50% Human Human -DTXSID1029251 Css NA 8.673 mg/L 3compartmentss NA 95% Human Human -DTXSID1029251 Css NA 1.014 mg/L PBTK NA 50% Human Human -DTXSID1029251 Css NA 5.26 mg/L PBTK NA 95% Human Human -DTXSID1029251 Clint NA 0.008954 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029251 Fup NA 0.5532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029251 Vd NA 0.4006 L/kg 1compartment NA NA Rat Human +DTXSID1029251 TK.Half.Life NA 3.769 hours 1compartment NA NA Human Human +DTXSID1029251 Css NA 0.8964 mg/L 3compartmentss NA 50% Human Human +DTXSID1029251 Css NA 5.123 mg/L 3compartmentss NA 95% Human Human +DTXSID1029251 Css NA 0.6744 mg/L PBTK NA 50% Human Human +DTXSID1029251 Css NA 3.18 mg/L PBTK NA 95% Human Human +DTXSID1029251 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029251 Fup 0.844 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029251 Vd NA 0.5104 L/kg 1compartment NA NA Rat Human DTXSID1029251 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029251 TK.Half.Life NA 1.585 hours 1compartment NA NA Rat Human -DTXSID1029251 Css NA 0.3882 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029251 Css NA 2.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029251 Css NA 0.2606 mg/L PBTK NA 50% Rat Human -DTXSID1029251 Css NA 1.254 mg/L PBTK NA 95% Rat Human -DTXSID1029255 Clint NA 0.1073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029255 Fup NA 0.578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029255 Vd NA 1.383 L/kg 1compartment NA NA Human Human -DTXSID1029255 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1029255 TK.Half.Life NA 15.04 hours 1compartment NA NA Human Human -DTXSID1029255 Css NA 1.084 mg/L 3compartmentss NA 50% Human Human -DTXSID1029255 Css NA 6.958 mg/L 3compartmentss NA 95% Human Human -DTXSID1029255 Css NA 0.9366 mg/L PBTK NA 50% Human Human -DTXSID1029255 Css NA 4.544 mg/L PBTK NA 95% Human Human -DTXSID1029255 Clint NA 0.1073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029255 Fup NA 0.578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029255 Vd NA 1.205 L/kg 1compartment NA NA Rat Human +DTXSID1029251 TK.Half.Life NA 1.333 hours 1compartment NA NA Rat Human +DTXSID1029251 Css NA 0.01697 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029251 Css NA 0.1172 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029251 Css NA 0.01212 mg/L PBTK NA 50% Rat Human +DTXSID1029251 Css NA 0.07144 mg/L PBTK NA 95% Rat Human +DTXSID1029255 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029255 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029255 Vd NA 2.035 L/kg 1compartment NA NA Human Human +DTXSID1029255 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1029255 TK.Half.Life NA 2.468 hours 1compartment NA NA Human Human +DTXSID1029255 Css NA 0.06098 mg/L 3compartmentss NA 50% Human Human +DTXSID1029255 Css NA 0.4465 mg/L 3compartmentss NA 95% Human Human +DTXSID1029255 Css NA 0.04936 mg/L PBTK NA 50% Human Human +DTXSID1029255 Css NA 0.321 mg/L PBTK NA 95% Human Human +DTXSID1029255 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029255 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029255 Vd NA 1.629 L/kg 1compartment NA NA Rat Human DTXSID1029255 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029255 TK.Half.Life NA 4.37 hours 1compartment NA NA Rat Human -DTXSID1029255 Css NA 0.3226 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029255 Css NA 2.011 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029255 Css NA 0.2682 mg/L PBTK NA 50% Rat Human -DTXSID1029255 Css NA 1.211 mg/L PBTK NA 95% Rat Human -DTXSID1029629 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029629 Fup NA 0.815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029629 Vd NA 0.88 L/kg 1compartment NA NA Human Human +DTXSID1029255 TK.Half.Life NA 0.8753 hours 1compartment NA NA Rat Human +DTXSID1029255 Css NA 0.007609 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029255 Css NA 0.04384 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029255 Css NA 0.00616 mg/L PBTK NA 50% Rat Human +DTXSID1029255 Css NA 0.03196 mg/L PBTK NA 95% Rat Human +DTXSID10293820 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10293820 Fup 0.714 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10293820 Vd NA 0.8479 L/kg 1compartment NA NA Human Human +DTXSID10293820 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10293820 TK.Half.Life NA 7.843 hours 1compartment NA NA Human Human +DTXSID10293820 Css NA 1.037 mg/L 3compartmentss NA 50% Human Human +DTXSID10293820 Css NA 7.169 mg/L 3compartmentss NA 95% Human Human +DTXSID10293820 Css NA 0.8514 mg/L PBTK NA 50% Human Human +DTXSID10293820 Css NA 4.524 mg/L PBTK NA 95% Human Human +DTXSID10293820 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10293820 Fup 0.714 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10293820 Vd NA 0.6622 L/kg 1compartment NA NA Rat Human +DTXSID10293820 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10293820 TK.Half.Life NA 2.931 hours 1compartment NA NA Rat Human +DTXSID10293820 Css NA 0.08831 mg/L 3compartmentss NA 50% Rat Human +DTXSID10293820 Css NA 0.3993 mg/L 3compartmentss NA 95% Rat Human +DTXSID10293820 Css NA 0.06728 mg/L PBTK NA 50% Rat Human +DTXSID10293820 Css NA 0.2454 mg/L PBTK NA 95% Rat Human +DTXSID1029629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029629 Fup 0.826 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029629 Vd NA 0.887 L/kg 1compartment NA NA Human Human DTXSID1029629 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1029629 TK.Half.Life NA 7.153 hours 1compartment NA NA Human Human -DTXSID1029629 Css NA 0.9819 mg/L 3compartmentss NA 50% Human Human -DTXSID1029629 Css NA 5.981 mg/L 3compartmentss NA 95% Human Human -DTXSID1029629 Css NA 0.8162 mg/L PBTK NA 50% Human Human -DTXSID1029629 Css NA 3.883 mg/L PBTK NA 95% Human Human -DTXSID1029629 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029629 Fup NA 0.815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029629 Vd NA 0.8449 L/kg 1compartment NA NA Rat Human +DTXSID1029629 TK.Half.Life NA 0.6883 hours 1compartment NA NA Human Human +DTXSID1029629 Css NA 0.02612 mg/L 3compartmentss NA 50% Human Human +DTXSID1029629 Css NA 0.2698 mg/L 3compartmentss NA 95% Human Human +DTXSID1029629 Css NA 0.02128 mg/L PBTK NA 50% Human Human +DTXSID1029629 Css NA 0.189 mg/L PBTK NA 95% Human Human +DTXSID1029629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029629 Fup 0.826 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029629 Vd NA 0.8517 L/kg 1compartment NA NA Rat Human DTXSID1029629 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029629 TK.Half.Life NA 2.298 hours 1compartment NA NA Rat Human -DTXSID1029629 Css NA 0.2518 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029629 Css NA 1.503 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029629 Css NA 0.203 mg/L PBTK NA 50% Rat Human -DTXSID1029629 Css NA 0.9016 mg/L PBTK NA 95% Rat Human +DTXSID1029629 TK.Half.Life NA 0.3174 hours 1compartment NA NA Rat Human +DTXSID1029629 Css NA 0.003065 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029629 Css NA 0.02669 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029629 Css NA 0.002578 mg/L PBTK NA 50% Rat Human +DTXSID1029629 Css NA 0.01891 mg/L PBTK NA 95% Rat Human DTXSID1029671 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1029671 Fup NA 0.6977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029671 Vd NA 0.4444 L/kg 1compartment NA NA Human Human +DTXSID1029671 Vd NA 0.3804 L/kg 1compartment NA NA Human Human DTXSID1029671 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1029671 TK.Half.Life NA 4.121 hours 1compartment NA NA Human Human -DTXSID1029671 Css NA 1.208 mg/L 3compartmentss NA 50% Human Human -DTXSID1029671 Css NA 7.415 mg/L 3compartmentss NA 95% Human Human -DTXSID1029671 Css NA 0.8864 mg/L PBTK NA 50% Human Human -DTXSID1029671 Css NA 4.511 mg/L PBTK NA 95% Human Human +DTXSID1029671 TK.Half.Life NA 3.527 hours 1compartment NA NA Human Human +DTXSID1029671 Css NA 1.053 mg/L 3compartmentss NA 50% Human Human +DTXSID1029671 Css NA 6.373 mg/L 3compartmentss NA 95% Human Human +DTXSID1029671 Css NA 0.7514 mg/L PBTK NA 50% Human Human +DTXSID1029671 Css NA 3.899 mg/L PBTK NA 95% Human Human DTXSID1029671 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1029671 Fup NA 0.6977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029671 Vd NA 0.4614 L/kg 1compartment NA NA Rat Human +DTXSID1029671 Vd NA 0.407 L/kg 1compartment NA NA Rat Human DTXSID1029671 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029671 TK.Half.Life NA 1.458 hours 1compartment NA NA Rat Human -DTXSID1029671 Css NA 0.3187 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029671 Css NA 1.896 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029671 Css NA 0.2232 mg/L PBTK NA 50% Rat Human -DTXSID1029671 Css NA 1.086 mg/L PBTK NA 95% Rat Human -DTXSID1029677 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029677 Fup NA 0.4066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029677 Vd NA 1.232 L/kg 1compartment NA NA Human Human -DTXSID1029677 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1029677 TK.Half.Life NA 22.26 hours 1compartment NA NA Human Human -DTXSID1029677 Css NA 1.885 mg/L 3compartmentss NA 50% Human Human -DTXSID1029677 Css NA 7.998 mg/L 3compartmentss NA 95% Human Human -DTXSID1029677 Css NA 1.502 mg/L PBTK NA 50% Human Human -DTXSID1029677 Css NA 5.368 mg/L PBTK NA 95% Human Human -DTXSID1029677 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029677 Fup NA 0.4066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029677 Vd NA 1.054 L/kg 1compartment NA NA Rat Human -DTXSID1029677 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029677 TK.Half.Life NA 5.899 hours 1compartment NA NA Rat Human -DTXSID1029677 Css NA 0.5102 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029677 Css NA 1.895 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029677 Css NA 0.3914 mg/L PBTK NA 50% Rat Human -DTXSID1029677 Css NA 1.168 mg/L PBTK NA 95% Rat Human -DTXSID1029679 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029679 Fup NA 0.1188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029679 Vd NA 2.941 L/kg 1compartment NA NA Human Human -DTXSID1029679 Days.Css NA 375 Days PBTK NA NA Human Human -DTXSID1029679 TK.Half.Life NA 1456 hours 1compartment NA NA Human Human -DTXSID1029679 Css NA 58.11 mg/L 3compartmentss NA 50% Human Human -DTXSID1029679 Css NA 167.1 mg/L 3compartmentss NA 95% Human Human -DTXSID1029679 Css NA 40.75 mg/L PBTK NA 50% Human Human -DTXSID1029679 Css NA 109.2 mg/L PBTK NA 95% Human Human -DTXSID1029679 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029679 Fup NA 0.1188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029679 Vd NA 2.212 L/kg 1compartment NA NA Rat Human -DTXSID1029679 Days.Css NA 94 Days PBTK NA NA Rat Human -DTXSID1029679 TK.Half.Life NA 120.3 hours 1compartment NA NA Rat Human -DTXSID1029679 Css NA 15.81 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029679 Css NA 36.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029679 Css NA 10.6 mg/L PBTK NA 50% Rat Human -DTXSID1029679 Css NA 22.06 mg/L PBTK NA 95% Rat Human +DTXSID1029671 TK.Half.Life NA 1.286 hours 1compartment NA NA Rat Human +DTXSID1029671 Css NA 0.02061 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029671 Css NA 0.1563 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029671 Css NA 0.0139 mg/L PBTK NA 50% Rat Human +DTXSID1029671 Css NA 0.09442 mg/L PBTK NA 95% Rat Human DTXSID1029889 Clint 135 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1029889 Fup NA 0.0306 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1029889 Vd NA 0.4097 L/kg 1compartment NA NA Human Human +DTXSID1029889 Fup 0.0543 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1029889 Vd NA 0.4513 L/kg 1compartment NA NA Human Human DTXSID1029889 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1029889 TK.Half.Life NA 0.7555 hours 1compartment NA NA Human Human -DTXSID1029889 Css NA 0.1796 mg/L 3compartmentss NA 50% Human Human -DTXSID1029889 Css NA 3.265 mg/L 3compartmentss NA 95% Human Human -DTXSID1029889 Css NA 0.1072 mg/L PBTK NA 50% Human Human -DTXSID1029889 Css NA 1.93 mg/L PBTK NA 95% Human Human +DTXSID1029889 TK.Half.Life NA 0.6484 hours 1compartment NA NA Human Human +DTXSID1029889 Css NA 0.04133 mg/L 3compartmentss NA 50% Human Human +DTXSID1029889 Css NA 0.8901 mg/L 3compartmentss NA 95% Human Human +DTXSID1029889 Css NA 0.0253 mg/L PBTK NA 50% Human Human +DTXSID1029889 Css NA 0.5217 mg/L PBTK NA 95% Human Human DTXSID1029889 Clint 135 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1029889 Fup NA 0.0306 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1029889 Vd NA 0.3374 L/kg 1compartment NA NA Rat Human +DTXSID1029889 Fup 0.0543 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1029889 Vd NA 0.3803 L/kg 1compartment NA NA Rat Human DTXSID1029889 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1029889 TK.Half.Life NA 0.3473 hours 1compartment NA NA Rat Human -DTXSID1029889 Css NA 0.107 mg/L 3compartmentss NA 50% Rat Human -DTXSID1029889 Css NA 1.562 mg/L 3compartmentss NA 95% Rat Human -DTXSID1029889 Css NA 0.06008 mg/L PBTK NA 50% Rat Human -DTXSID1029889 Css NA 0.8627 mg/L PBTK NA 95% Rat Human -DTXSID1030317 Clint NA 1.122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1030317 Fup NA 0.6764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1030317 Vd NA 2.544 L/kg 1compartment NA NA Human Human -DTXSID1030317 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1030317 TK.Half.Life NA 20.25 hours 1compartment NA NA Human Human -DTXSID1030317 Css NA 0.8074 mg/L 3compartmentss NA 50% Human Human -DTXSID1030317 Css NA 4.063 mg/L 3compartmentss NA 95% Human Human -DTXSID1030317 Css NA 0.6776 mg/L PBTK NA 50% Human Human -DTXSID1030317 Css NA 2.857 mg/L PBTK NA 95% Human Human -DTXSID1030317 Clint NA 1.122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1030317 Fup NA 0.6764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1030317 Vd NA 2.007 L/kg 1compartment NA NA Rat Human +DTXSID1029889 TK.Half.Life NA 0.2868 hours 1compartment NA NA Rat Human +DTXSID1029889 Css NA 0.0004245 mg/L 3compartmentss NA 50% Rat Human +DTXSID1029889 Css NA 0.008903 mg/L 3compartmentss NA 95% Rat Human +DTXSID1029889 Css NA 0.0002447 mg/L PBTK NA 50% Rat Human +DTXSID1029889 Css NA 0.004959 mg/L PBTK NA 95% Rat Human +DTXSID1030317 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1030317 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1030317 Vd NA 1.498 L/kg 1compartment NA NA Human Human +DTXSID1030317 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1030317 TK.Half.Life NA 2.797 hours 1compartment NA NA Human Human +DTXSID1030317 Css NA 0.1317 mg/L 3compartmentss NA 50% Human Human +DTXSID1030317 Css NA 0.8939 mg/L 3compartmentss NA 95% Human Human +DTXSID1030317 Css NA 0.09343 mg/L PBTK NA 50% Human Human +DTXSID1030317 Css NA 0.6062 mg/L PBTK NA 95% Human Human +DTXSID1030317 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1030317 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1030317 Vd NA 1.172 L/kg 1compartment NA NA Rat Human DTXSID1030317 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1030317 TK.Half.Life NA 4.524 hours 1compartment NA NA Rat Human -DTXSID1030317 Css NA 0.3301 mg/L 3compartmentss NA 50% Rat Human -DTXSID1030317 Css NA 1.418 mg/L 3compartmentss NA 95% Rat Human -DTXSID1030317 Css NA 0.27 mg/L PBTK NA 50% Rat Human -DTXSID1030317 Css NA 0.8965 mg/L PBTK NA 95% Rat Human -DTXSID1030319 Clint NA 13.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1030319 Fup NA 0.0597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1030319 Vd NA 1.771 L/kg 1compartment NA NA Human Human +DTXSID1030317 TK.Half.Life NA 1.085 hours 1compartment NA NA Rat Human +DTXSID1030317 Css NA 0.01704 mg/L 3compartmentss NA 50% Rat Human +DTXSID1030317 Css NA 0.08639 mg/L 3compartmentss NA 95% Rat Human +DTXSID1030317 Css NA 0.0119 mg/L PBTK NA 50% Rat Human +DTXSID1030317 Css NA 0.05789 mg/L PBTK NA 95% Rat Human +DTXSID1030319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1030319 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1030319 Vd NA 1.955 L/kg 1compartment NA NA Human Human DTXSID1030319 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1030319 TK.Half.Life NA 11.7 hours 1compartment NA NA Human Human -DTXSID1030319 Css NA 0.9288 mg/L 3compartmentss NA 50% Human Human -DTXSID1030319 Css NA 6.266 mg/L 3compartmentss NA 95% Human Human -DTXSID1030319 Css NA 0.6053 mg/L PBTK NA 50% Human Human -DTXSID1030319 Css NA 3.858 mg/L PBTK NA 95% Human Human -DTXSID1030319 Clint NA 13.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1030319 Fup NA 0.0597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1030319 Vd NA 1.333 L/kg 1compartment NA NA Rat Human +DTXSID1030319 TK.Half.Life NA 4.423 hours 1compartment NA NA Human Human +DTXSID1030319 Css NA 0.1786 mg/L 3compartmentss NA 50% Human Human +DTXSID1030319 Css NA 1.256 mg/L 3compartmentss NA 95% Human Human +DTXSID1030319 Css NA 0.1273 mg/L PBTK NA 50% Human Human +DTXSID1030319 Css NA 0.8546 mg/L PBTK NA 95% Human Human +DTXSID1030319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1030319 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1030319 Vd NA 1.502 L/kg 1compartment NA NA Rat Human DTXSID1030319 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1030319 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human -DTXSID1030319 Css NA 0.5117 mg/L 3compartmentss NA 50% Rat Human -DTXSID1030319 Css NA 2.724 mg/L 3compartmentss NA 95% Rat Human -DTXSID1030319 Css NA 0.315 mg/L PBTK NA 50% Rat Human -DTXSID1030319 Css NA 1.606 mg/L PBTK NA 95% Rat Human -DTXSID1030604 Clint NA 1.057 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1030604 Fup NA 0.1874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1030604 Vd NA 0.3383 L/kg 1compartment NA NA Human Human +DTXSID1030319 TK.Half.Life NA 1.521 hours 1compartment NA NA Rat Human +DTXSID1030319 Css NA 0.02275 mg/L 3compartmentss NA 50% Rat Human +DTXSID1030319 Css NA 0.1158 mg/L 3compartmentss NA 95% Rat Human +DTXSID1030319 Css NA 0.0161 mg/L PBTK NA 50% Rat Human +DTXSID1030319 Css NA 0.07836 mg/L PBTK NA 95% Rat Human +DTXSID1030604 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1030604 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1030604 Vd NA 0.4629 L/kg 1compartment NA NA Human Human DTXSID1030604 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1030604 TK.Half.Life NA 4.365 hours 1compartment NA NA Human Human -DTXSID1030604 Css NA 1.627 mg/L 3compartmentss NA 50% Human Human -DTXSID1030604 Css NA 7.295 mg/L 3compartmentss NA 95% Human Human -DTXSID1030604 Css NA 1.066 mg/L PBTK NA 50% Human Human -DTXSID1030604 Css NA 4.47 mg/L PBTK NA 95% Human Human -DTXSID1030604 Clint NA 1.057 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1030604 Fup NA 0.1874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1030604 Vd NA 0.336 L/kg 1compartment NA NA Rat Human +DTXSID1030604 TK.Half.Life NA 7.415 hours 1compartment NA NA Human Human +DTXSID1030604 Css NA 1.769 mg/L 3compartmentss NA 50% Human Human +DTXSID1030604 Css NA 7.842 mg/L 3compartmentss NA 95% Human Human +DTXSID1030604 Css NA 1.292 mg/L PBTK NA 50% Human Human +DTXSID1030604 Css NA 4.939 mg/L PBTK NA 95% Human Human +DTXSID1030604 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1030604 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1030604 Vd NA 0.4643 L/kg 1compartment NA NA Rat Human DTXSID1030604 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1030604 TK.Half.Life NA 2.165 hours 1compartment NA NA Rat Human -DTXSID1030604 Css NA 0.6725 mg/L 3compartmentss NA 50% Rat Human -DTXSID1030604 Css NA 2.252 mg/L 3compartmentss NA 95% Rat Human -DTXSID1030604 Css NA 0.415 mg/L PBTK NA 50% Rat Human -DTXSID1030604 Css NA 1.278 mg/L PBTK NA 95% Rat Human -DTXSID1030606 Clint NA 1.062 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1030606 Fup NA 0.5977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1030606 Vd NA 0.6719 L/kg 1compartment NA NA Human Human +DTXSID1030604 TK.Half.Life NA 2.534 hours 1compartment NA NA Rat Human +DTXSID1030604 Css NA 0.1124 mg/L 3compartmentss NA 50% Rat Human +DTXSID1030604 Css NA 0.4353 mg/L 3compartmentss NA 95% Rat Human +DTXSID1030604 Css NA 0.08085 mg/L PBTK NA 50% Rat Human +DTXSID1030604 Css NA 0.2648 mg/L PBTK NA 95% Rat Human +DTXSID1030606 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1030606 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1030606 Vd NA 0.684 L/kg 1compartment NA NA Human Human DTXSID1030606 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1030606 TK.Half.Life NA 2.833 hours 1compartment NA NA Human Human -DTXSID1030606 Css NA 0.466 mg/L 3compartmentss NA 50% Human Human -DTXSID1030606 Css NA 3.254 mg/L 3compartmentss NA 95% Human Human -DTXSID1030606 Css NA 0.3676 mg/L PBTK NA 50% Human Human -DTXSID1030606 Css NA 2.087 mg/L PBTK NA 95% Human Human -DTXSID1030606 Clint NA 1.062 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1030606 Fup NA 0.5977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1030606 Vd NA 0.676 L/kg 1compartment NA NA Rat Human +DTXSID1030606 TK.Half.Life NA 6.25 hours 1compartment NA NA Human Human +DTXSID1030606 Css NA 0.9321 mg/L 3compartmentss NA 50% Human Human +DTXSID1030606 Css NA 5.841 mg/L 3compartmentss NA 95% Human Human +DTXSID1030606 Css NA 0.7498 mg/L PBTK NA 50% Human Human +DTXSID1030606 Css NA 3.723 mg/L PBTK NA 95% Human Human +DTXSID1030606 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1030606 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1030606 Vd NA 0.7001 L/kg 1compartment NA NA Rat Human DTXSID1030606 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1030606 TK.Half.Life NA 1.389 hours 1compartment NA NA Rat Human -DTXSID1030606 Css NA 0.1788 mg/L 3compartmentss NA 50% Rat Human -DTXSID1030606 Css NA 1.186 mg/L 3compartmentss NA 95% Rat Human -DTXSID1030606 Css NA 0.1363 mg/L PBTK NA 50% Rat Human -DTXSID1030606 Css NA 0.6958 mg/L PBTK NA 95% Rat Human -DTXSID1031096 Clint NA 410.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1031096 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1031096 Vd NA 969.8 L/kg 1compartment NA NA Human Human -DTXSID1031096 Days.Css NA 382 Days PBTK NA NA Human Human -DTXSID1031096 TK.Half.Life NA 1547 hours 1compartment NA NA Human Human -DTXSID1031096 Css NA 0.0008635 mg/L 3compartmentss NA 50% Human Human -DTXSID1031096 Css NA 0.00508 mg/L 3compartmentss NA 95% Human Human -DTXSID1031096 Css NA 0.1335 mg/L PBTK NA 50% Human Human -DTXSID1031096 Css NA 0.7373 mg/L PBTK NA 95% Human Human -DTXSID1031096 Clint NA 410.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1031096 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1031096 Vd NA 887.8 L/kg 1compartment NA NA Rat Human -DTXSID1031096 Days.Css NA 262 Days PBTK NA NA Rat Human -DTXSID1031096 TK.Half.Life NA 261.1 hours 1compartment NA NA Rat Human -DTXSID1031096 Css NA 0.0004378 mg/L 3compartmentss NA 50% Rat Human -DTXSID1031096 Css NA 0.001865 mg/L 3compartmentss NA 95% Rat Human -DTXSID1031096 Css NA 0.0717 mg/L PBTK NA 50% Rat Human -DTXSID1031096 Css NA 0.311 mg/L PBTK NA 95% Rat Human +DTXSID1030606 TK.Half.Life NA 2.175 hours 1compartment NA NA Rat Human +DTXSID1030606 Css NA 0.01789 mg/L 3compartmentss NA 50% Rat Human +DTXSID1030606 Css NA 0.1442 mg/L 3compartmentss NA 95% Rat Human +DTXSID1030606 Css NA 0.01372 mg/L PBTK NA 50% Rat Human +DTXSID1030606 Css NA 0.09147 mg/L PBTK NA 95% Rat Human DTXSID1031591 Clint NA 0.002906 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1031591 Fup NA 0.4611 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1031591 Vd NA 0.4575 L/kg 1compartment NA NA Human Human +DTXSID1031591 Vd NA 0.4599 L/kg 1compartment NA NA Human Human DTXSID1031591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1031591 TK.Half.Life NA 6.383 hours 1compartment NA NA Human Human -DTXSID1031591 Css NA 1.612 mg/L 3compartmentss NA 50% Human Human -DTXSID1031591 Css NA 7.75 mg/L 3compartmentss NA 95% Human Human -DTXSID1031591 Css NA 1.177 mg/L PBTK NA 50% Human Human -DTXSID1031591 Css NA 4.844 mg/L PBTK NA 95% Human Human +DTXSID1031591 TK.Half.Life NA 6.418 hours 1compartment NA NA Human Human +DTXSID1031591 Css NA 1.362 mg/L 3compartmentss NA 50% Human Human +DTXSID1031591 Css NA 6.382 mg/L 3compartmentss NA 95% Human Human +DTXSID1031591 Css NA 1 mg/L PBTK NA 50% Human Human +DTXSID1031591 Css NA 4.011 mg/L PBTK NA 95% Human Human DTXSID1031591 Clint NA 0.002906 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1031591 Fup NA 0.4611 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1031591 Vd NA 0.4767 L/kg 1compartment NA NA Rat Human +DTXSID1031591 Vd NA 0.479 L/kg 1compartment NA NA Rat Human DTXSID1031591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1031591 TK.Half.Life NA 2.273 hours 1compartment NA NA Rat Human -DTXSID1031591 Css NA 0.4404 mg/L 3compartmentss NA 50% Rat Human -DTXSID1031591 Css NA 1.885 mg/L 3compartmentss NA 95% Rat Human -DTXSID1031591 Css NA 0.3062 mg/L PBTK NA 50% Rat Human -DTXSID1031591 Css NA 1.099 mg/L PBTK NA 95% Rat Human -DTXSID1031626 Clint NA 4.324 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1031626 Fup NA 0.375 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1031626 Vd NA 1.612 L/kg 1compartment NA NA Human Human +DTXSID1031591 TK.Half.Life NA 2.284 hours 1compartment NA NA Rat Human +DTXSID1031591 Css NA 0.02506 mg/L 3compartmentss NA 50% Rat Human +DTXSID1031591 Css NA 0.1687 mg/L 3compartmentss NA 95% Rat Human +DTXSID1031591 Css NA 0.01778 mg/L PBTK NA 50% Rat Human +DTXSID1031591 Css NA 0.1051 mg/L PBTK NA 95% Rat Human +DTXSID1031626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1031626 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1031626 Vd NA 1.051 L/kg 1compartment NA NA Human Human DTXSID1031626 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1031626 TK.Half.Life NA 5.078 hours 1compartment NA NA Human Human -DTXSID1031626 Css NA 0.2914 mg/L 3compartmentss NA 50% Human Human -DTXSID1031626 Css NA 1.664 mg/L 3compartmentss NA 95% Human Human -DTXSID1031626 Css NA 0.2296 mg/L PBTK NA 50% Human Human -DTXSID1031626 Css NA 1.157 mg/L PBTK NA 95% Human Human -DTXSID1031626 Clint NA 4.324 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1031626 Fup NA 0.375 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1031626 Vd NA 1.314 L/kg 1compartment NA NA Rat Human +DTXSID1031626 TK.Half.Life NA 2.013 hours 1compartment NA NA Human Human +DTXSID1031626 Css NA 0.1502 mg/L 3compartmentss NA 50% Human Human +DTXSID1031626 Css NA 1.134 mg/L 3compartmentss NA 95% Human Human +DTXSID1031626 Css NA 0.1024 mg/L PBTK NA 50% Human Human +DTXSID1031626 Css NA 0.7395 mg/L PBTK NA 95% Human Human +DTXSID1031626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1031626 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1031626 Vd NA 0.8488 L/kg 1compartment NA NA Rat Human DTXSID1031626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1031626 TK.Half.Life NA 1.994 hours 1compartment NA NA Rat Human -DTXSID1031626 Css NA 0.142 mg/L 3compartmentss NA 50% Rat Human -DTXSID1031626 Css NA 0.6065 mg/L 3compartmentss NA 95% Rat Human -DTXSID1031626 Css NA 0.1086 mg/L PBTK NA 50% Rat Human -DTXSID1031626 Css NA 0.395 mg/L PBTK NA 95% Rat Human -DTXSID1032278 Clint NA 37.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1031626 TK.Half.Life NA 0.8724 hours 1compartment NA NA Rat Human +DTXSID1031626 Css NA 0.01928 mg/L 3compartmentss NA 50% Rat Human +DTXSID1031626 Css NA 0.115 mg/L 3compartmentss NA 95% Rat Human +DTXSID1031626 Css NA 0.01297 mg/L PBTK NA 50% Rat Human +DTXSID1031626 Css NA 0.0715 mg/L PBTK NA 95% Rat Human +DTXSID1032278 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1032278 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1032278 Vd NA 10.37 L/kg 1compartment NA NA Human Human +DTXSID1032278 Vd NA 10.11 L/kg 1compartment NA NA Human Human DTXSID1032278 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1032278 TK.Half.Life NA 3.89 hours 1compartment NA NA Human Human -DTXSID1032278 Css NA 0.006236 mg/L 3compartmentss NA 50% Human Human -DTXSID1032278 Css NA 0.06741 mg/L 3compartmentss NA 95% Human Human -DTXSID1032278 Css NA 0.01466 mg/L PBTK NA 50% Human Human -DTXSID1032278 Css NA 0.1033 mg/L PBTK NA 95% Human Human -DTXSID1032278 Clint NA 37.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1032278 TK.Half.Life NA 5.034 hours 1compartment NA NA Human Human +DTXSID1032278 Css NA 0.003876 mg/L 3compartmentss NA 50% Human Human +DTXSID1032278 Css NA 0.06182 mg/L 3compartmentss NA 95% Human Human +DTXSID1032278 Css NA 0.009006 mg/L PBTK NA 50% Human Human +DTXSID1032278 Css NA 0.09846 mg/L PBTK NA 95% Human Human +DTXSID1032278 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1032278 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1032278 Vd NA 10.81 L/kg 1compartment NA NA Rat Human +DTXSID1032278 Vd NA 10.56 L/kg 1compartment NA NA Rat Human DTXSID1032278 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1032278 TK.Half.Life NA 1.955 hours 1compartment NA NA Rat Human -DTXSID1032278 Css NA 0.0032 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032278 Css NA 0.02744 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032278 Css NA 0.007832 mg/L PBTK NA 50% Rat Human -DTXSID1032278 Css NA 0.0441 mg/L PBTK NA 95% Rat Human -DTXSID1032303 Clint NA 14.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032303 Fup NA 0.0323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032303 Vd NA 10.06 L/kg 1compartment NA NA Human Human -DTXSID1032303 Days.Css NA 100 Days PBTK NA NA Human Human -DTXSID1032303 TK.Half.Life NA 451.6 hours 1compartment NA NA Human Human -DTXSID1032303 Css NA 3.068 mg/L 3compartmentss NA 50% Human Human -DTXSID1032303 Css NA 17.83 mg/L 3compartmentss NA 95% Human Human -DTXSID1032303 Css NA 3.682 mg/L PBTK NA 50% Human Human -DTXSID1032303 Css NA 20.42 mg/L PBTK NA 95% Human Human -DTXSID1032303 Clint NA 14.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032303 Fup NA 0.0323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032303 Vd NA 7.922 L/kg 1compartment NA NA Rat Human -DTXSID1032303 Days.Css NA 59 Days PBTK NA NA Rat Human -DTXSID1032303 TK.Half.Life NA 61.23 hours 1compartment NA NA Rat Human -DTXSID1032303 Css NA 1.661 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032303 Css NA 7.003 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032303 Css NA 1.993 mg/L PBTK NA 50% Rat Human -DTXSID1032303 Css NA 8.137 mg/L PBTK NA 95% Rat Human -DTXSID1032309 Clint NA 10.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032309 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032309 Vd NA 2.152 L/kg 1compartment NA NA Human Human -DTXSID1032309 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID1032309 TK.Half.Life NA 41.71 hours 1compartment NA NA Human Human -DTXSID1032309 Css NA 2.982 mg/L 3compartmentss NA 50% Human Human -DTXSID1032309 Css NA 22.4 mg/L 3compartmentss NA 95% Human Human -DTXSID1032309 Css NA 1.942 mg/L PBTK NA 50% Human Human -DTXSID1032309 Css NA 13.79 mg/L PBTK NA 95% Human Human -DTXSID1032309 Clint NA 10.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032309 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032309 Vd NA 1.603 L/kg 1compartment NA NA Rat Human -DTXSID1032309 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1032309 TK.Half.Life NA 12.31 hours 1compartment NA NA Rat Human -DTXSID1032309 Css NA 1.639 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032309 Css NA 9.39 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032309 Css NA 1.005 mg/L PBTK NA 50% Rat Human -DTXSID1032309 Css NA 5.478 mg/L PBTK NA 95% Rat Human +DTXSID1032278 TK.Half.Life NA 2.703 hours 1compartment NA NA Rat Human +DTXSID1032278 Css NA 3.09e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032278 Css NA 0.0004935 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032278 Css NA 7.56e-05 mg/L PBTK NA 50% Rat Human +DTXSID1032278 Css NA 0.0008144 mg/L PBTK NA 95% Rat Human +DTXSID1032303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032303 Fup 0.0271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032303 Vd NA 4.837 L/kg 1compartment NA NA Human Human +DTXSID1032303 Days.Css NA 26 Days PBTK NA NA Human Human +DTXSID1032303 TK.Half.Life NA 145.1 hours 1compartment NA NA Human Human +DTXSID1032303 Css NA 1.617 mg/L 3compartmentss NA 50% Human Human +DTXSID1032303 Css NA 10.43 mg/L 3compartmentss NA 95% Human Human +DTXSID1032303 Css NA 1.292 mg/L PBTK NA 50% Human Human +DTXSID1032303 Css NA 8.204 mg/L PBTK NA 95% Human Human +DTXSID1032303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032303 Fup 0.0271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032303 Vd NA 3.688 L/kg 1compartment NA NA Rat Human +DTXSID1032303 Days.Css NA 15 Days PBTK NA NA Rat Human +DTXSID1032303 TK.Half.Life NA 19.49 hours 1compartment NA NA Rat Human +DTXSID1032303 Css NA 0.01738 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032303 Css NA 0.1035 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032303 Css NA 0.01355 mg/L PBTK NA 50% Rat Human +DTXSID1032303 Css NA 0.07911 mg/L PBTK NA 95% Rat Human +DTXSID1032309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032309 Fup 0.0297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032309 Vd NA 2.316 L/kg 1compartment NA NA Human Human +DTXSID1032309 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1032309 TK.Half.Life NA 20.62 hours 1compartment NA NA Human Human +DTXSID1032309 Css NA 1.227 mg/L 3compartmentss NA 50% Human Human +DTXSID1032309 Css NA 9.748 mg/L 3compartmentss NA 95% Human Human +DTXSID1032309 Css NA 0.8098 mg/L PBTK NA 50% Human Human +DTXSID1032309 Css NA 6.125 mg/L PBTK NA 95% Human Human +DTXSID1032309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032309 Fup 0.0297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032309 Vd NA 1.728 L/kg 1compartment NA NA Rat Human +DTXSID1032309 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1032309 TK.Half.Life NA 5.733 hours 1compartment NA NA Rat Human +DTXSID1032309 Css NA 0.1588 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032309 Css NA 0.9708 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032309 Css NA 0.1028 mg/L PBTK NA 50% Rat Human +DTXSID1032309 Css NA 0.608 mg/L PBTK NA 95% Rat Human DTXSID1032355 Clint 3.038 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032355 Fup 0.1734 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032355 Vd NA 1.59 L/kg 1compartment NA NA Human Human DTXSID1032355 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1032355 TK.Half.Life NA 13.23 hours 1compartment NA NA Human Human -DTXSID1032355 Css NA 0.9692 mg/L 3compartmentss NA 50% Human Human -DTXSID1032355 Css NA 4.808 mg/L 3compartmentss NA 95% Human Human -DTXSID1032355 Css NA 0.6859 mg/L PBTK NA 50% Human Human -DTXSID1032355 Css NA 3.115 mg/L PBTK NA 95% Human Human +DTXSID1032355 Css NA 0.9358 mg/L 3compartmentss NA 50% Human Human +DTXSID1032355 Css NA 4.73 mg/L 3compartmentss NA 95% Human Human +DTXSID1032355 Css NA 0.6615 mg/L PBTK NA 50% Human Human +DTXSID1032355 Css NA 3.053 mg/L PBTK NA 95% Human Human DTXSID1032355 Clint 3.038 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1032355 Fup 0.1734 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1032355 Vd NA 1.239 L/kg 1compartment NA NA Rat Human DTXSID1032355 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1032355 TK.Half.Life NA 4.787 hours 1compartment NA NA Rat Human -DTXSID1032355 Css NA 0.468 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032355 Css NA 1.652 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032355 Css NA 0.3158 mg/L PBTK NA 50% Rat Human -DTXSID1032355 Css NA 1.008 mg/L PBTK NA 95% Rat Human +DTXSID1032355 Css NA 0.1071 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032355 Css NA 0.3729 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032355 Css NA 0.07462 mg/L PBTK NA 50% Rat Human +DTXSID1032355 Css NA 0.2372 mg/L PBTK NA 95% Rat Human DTXSID1032359 Clint 37.77 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032359 Fup 0.002141 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032359 Vd NA 0.907 L/kg 1compartment NA NA Human Human DTXSID1032359 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID1032359 TK.Half.Life NA 24.4 hours 1compartment NA NA Human Human -DTXSID1032359 Css NA 4.581 mg/L 3compartmentss NA 50% Human Human -DTXSID1032359 Css NA 43.94 mg/L 3compartmentss NA 95% Human Human -DTXSID1032359 Css NA 2.935 mg/L PBTK NA 50% Human Human -DTXSID1032359 Css NA 26.61 mg/L PBTK NA 95% Human Human +DTXSID1032359 Css NA 4.38 mg/L 3compartmentss NA 50% Human Human +DTXSID1032359 Css NA 42.15 mg/L 3compartmentss NA 95% Human Human +DTXSID1032359 Css NA 2.818 mg/L PBTK NA 50% Human Human +DTXSID1032359 Css NA 27.13 mg/L PBTK NA 95% Human Human DTXSID1032359 Clint 8.81 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID1032359 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID1032359 Css NA 5.361 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1032359 Css NA 37.18 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1032359 Css NA 1.114 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1032359 Css NA 7.514 mg/L 3compartmentss NA 95% Rat Rat DTXSID1032482 Clint 22.64 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID1032482 Fup NA 0.0178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032482 Vd NA 1.513 L/kg 1compartment NA NA Human Human -DTXSID1032482 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1032482 TK.Half.Life NA 14.63 hours 1compartment NA NA Human Human -DTXSID1032482 Css NA 1.551 mg/L 3compartmentss NA 50% Human Human -DTXSID1032482 Css NA 13.57 mg/L 3compartmentss NA 95% Human Human -DTXSID1032482 Css NA 0.97 mg/L PBTK NA 50% Human Human -DTXSID1032482 Css NA 8.169 mg/L PBTK NA 95% Human Human +DTXSID1032482 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032482 Vd NA 2.523 L/kg 1compartment NA NA Human Human +DTXSID1032482 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1032482 TK.Half.Life NA 29.66 hours 1compartment NA NA Human Human +DTXSID1032482 Css NA 1.628 mg/L 3compartmentss NA 50% Human Human +DTXSID1032482 Css NA 11.59 mg/L 3compartmentss NA 95% Human Human +DTXSID1032482 Css NA 1.081 mg/L PBTK NA 50% Human Human +DTXSID1032482 Css NA 7.506 mg/L PBTK NA 95% Human Human DTXSID1032482 Clint 22.64 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID1032482 Fup NA 0.0178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032482 Vd NA 1.121 L/kg 1compartment NA NA Rat Human -DTXSID1032482 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1032482 TK.Half.Life NA 5.608 hours 1compartment NA NA Rat Human -DTXSID1032482 Css NA 0.8687 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032482 Css NA 6.028 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032482 Css NA 0.5077 mg/L PBTK NA 50% Rat Human -DTXSID1032482 Css NA 3.393 mg/L PBTK NA 95% Rat Human -DTXSID1032484 Clint NA 3536 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032484 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032484 Vd NA 3.074 L/kg 1compartment NA NA Human Human -DTXSID1032484 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1032484 TK.Half.Life NA 3.092 hours 1compartment NA NA Human Human -DTXSID1032484 Css NA 0.02248 mg/L 3compartmentss NA 50% Human Human -DTXSID1032484 Css NA 0.1282 mg/L 3compartmentss NA 95% Human Human -DTXSID1032484 Css NA 0.01557 mg/L PBTK NA 50% Human Human -DTXSID1032484 Css NA 0.08768 mg/L PBTK NA 95% Human Human -DTXSID1032484 Clint NA 3536 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032484 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032484 Vd NA 2.302 L/kg 1compartment NA NA Rat Human -DTXSID1032484 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1032484 TK.Half.Life NA 0.9082 hours 1compartment NA NA Rat Human -DTXSID1032484 Css NA 0.01287 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032484 Css NA 0.05493 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032484 Css NA 0.008467 mg/L PBTK NA 50% Rat Human -DTXSID1032484 Css NA 0.03603 mg/L PBTK NA 95% Rat Human +DTXSID1032482 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032482 Vd NA 1.883 L/kg 1compartment NA NA Rat Human +DTXSID1032482 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1032482 TK.Half.Life NA 7.239 hours 1compartment NA NA Rat Human +DTXSID1032482 Css NA 0.2106 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032482 Css NA 1.257 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032482 Css NA 0.1372 mg/L PBTK NA 50% Rat Human +DTXSID1032482 Css NA 0.7809 mg/L PBTK NA 95% Rat Human +DTXSID1032484 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032484 Fup 0.0124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032484 Vd NA 3.114 L/kg 1compartment NA NA Human Human +DTXSID1032484 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID1032484 TK.Half.Life NA 93.64 hours 1compartment NA NA Human Human +DTXSID1032484 Css NA 3.466 mg/L 3compartmentss NA 50% Human Human +DTXSID1032484 Css NA 19.86 mg/L 3compartmentss NA 95% Human Human +DTXSID1032484 Css NA 2.414 mg/L PBTK NA 50% Human Human +DTXSID1032484 Css NA 13.55 mg/L PBTK NA 95% Human Human +DTXSID1032484 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032484 Fup 0.0124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032484 Vd NA 2.331 L/kg 1compartment NA NA Rat Human +DTXSID1032484 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID1032484 TK.Half.Life NA 12.67 hours 1compartment NA NA Rat Human +DTXSID1032484 Css NA 0.4564 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032484 Css NA 2.261 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032484 Css NA 0.3119 mg/L PBTK NA 50% Rat Human +DTXSID1032484 Css NA 1.581 mg/L PBTK NA 95% Rat Human DTXSID1032488 Clint 41.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032488 Fup 0.01139 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032488 Vd NA 1.192 L/kg 1compartment NA NA Human Human DTXSID1032488 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1032488 TK.Half.Life NA 6.876 hours 1compartment NA NA Human Human -DTXSID1032488 Css NA 0.869 mg/L 3compartmentss NA 50% Human Human -DTXSID1032488 Css NA 9.031 mg/L 3compartmentss NA 95% Human Human -DTXSID1032488 Css NA 0.5451 mg/L PBTK NA 50% Human Human -DTXSID1032488 Css NA 5.383 mg/L PBTK NA 95% Human Human +DTXSID1032488 Css NA 0.8666 mg/L 3compartmentss NA 50% Human Human +DTXSID1032488 Css NA 8.495 mg/L 3compartmentss NA 95% Human Human +DTXSID1032488 Css NA 0.5445 mg/L PBTK NA 50% Human Human +DTXSID1032488 Css NA 4.989 mg/L PBTK NA 95% Human Human DTXSID1032488 Clint 41.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1032488 Fup 0.01139 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1032488 Vd NA 0.9656 L/kg 1compartment NA NA Rat Human DTXSID1032488 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1032488 TK.Half.Life NA 3.304 hours 1compartment NA NA Rat Human -DTXSID1032488 Css NA 0.503 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032488 Css NA 4.242 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032488 Css NA 0.2943 mg/L PBTK NA 50% Rat Human -DTXSID1032488 Css NA 2.362 mg/L PBTK NA 95% Rat Human -DTXSID1032511 Clint NA 5.011 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032511 Fup NA 0.679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032511 Vd NA 1.131 L/kg 1compartment NA NA Human Human +DTXSID1032488 Css NA 0.1135 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032488 Css NA 0.9823 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032488 Css NA 0.0687 mg/L PBTK NA 50% Rat Human +DTXSID1032488 Css NA 0.5678 mg/L PBTK NA 95% Rat Human +DTXSID1032511 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032511 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032511 Vd NA 0.6164 L/kg 1compartment NA NA Human Human DTXSID1032511 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1032511 TK.Half.Life NA 1.74 hours 1compartment NA NA Human Human -DTXSID1032511 Css NA 0.1221 mg/L 3compartmentss NA 50% Human Human -DTXSID1032511 Css NA 1.102 mg/L 3compartmentss NA 95% Human Human -DTXSID1032511 Css NA 0.105 mg/L PBTK NA 50% Human Human -DTXSID1032511 Css NA 0.77 mg/L PBTK NA 95% Human Human -DTXSID1032511 Clint NA 5.011 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032511 Fup NA 0.679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032511 Vd NA 1.05 L/kg 1compartment NA NA Rat Human +DTXSID1032511 TK.Half.Life NA 9.238 hours 1compartment NA NA Human Human +DTXSID1032511 Css NA 1.598 mg/L 3compartmentss NA 50% Human Human +DTXSID1032511 Css NA 7.142 mg/L 3compartmentss NA 95% Human Human +DTXSID1032511 Css NA 1.204 mg/L PBTK NA 50% Human Human +DTXSID1032511 Css NA 4.594 mg/L PBTK NA 95% Human Human +DTXSID1032511 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032511 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032511 Vd NA 0.6139 L/kg 1compartment NA NA Rat Human DTXSID1032511 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1032511 TK.Half.Life NA 0.8515 hours 1compartment NA NA Rat Human -DTXSID1032511 Css NA 0.05806 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032511 Css NA 0.4256 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032511 Css NA 0.04882 mg/L PBTK NA 50% Rat Human -DTXSID1032511 Css NA 0.2669 mg/L PBTK NA 95% Rat Human -DTXSID1032513 Clint NA 6.141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032513 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032513 Vd NA 1.042 L/kg 1compartment NA NA Human Human +DTXSID1032511 TK.Half.Life NA 3.122 hours 1compartment NA NA Rat Human +DTXSID1032511 Css NA 0.1028 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032511 Css NA 0.4137 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032511 Css NA 0.07658 mg/L PBTK NA 50% Rat Human +DTXSID1032511 Css NA 0.2545 mg/L PBTK NA 95% Rat Human +DTXSID1032513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032513 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032513 Vd NA 0.8572 L/kg 1compartment NA NA Human Human DTXSID1032513 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1032513 TK.Half.Life NA 1.065 hours 1compartment NA NA Human Human -DTXSID1032513 Css NA 0.07366 mg/L 3compartmentss NA 50% Human Human -DTXSID1032513 Css NA 0.7407 mg/L 3compartmentss NA 95% Human Human -DTXSID1032513 Css NA 0.06483 mg/L PBTK NA 50% Human Human -DTXSID1032513 Css NA 0.5396 mg/L PBTK NA 95% Human Human -DTXSID1032513 Clint NA 6.141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032513 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032513 Vd NA 1.036 L/kg 1compartment NA NA Rat Human +DTXSID1032513 TK.Half.Life NA 0.7056 hours 1compartment NA NA Human Human +DTXSID1032513 Css NA 0.02806 mg/L 3compartmentss NA 50% Human Human +DTXSID1032513 Css NA 0.3045 mg/L 3compartmentss NA 95% Human Human +DTXSID1032513 Css NA 0.02316 mg/L PBTK NA 50% Human Human +DTXSID1032513 Css NA 0.2116 mg/L PBTK NA 95% Human Human +DTXSID1032513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032513 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032513 Vd NA 0.8472 L/kg 1compartment NA NA Rat Human DTXSID1032513 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1032513 TK.Half.Life NA 0.5484 hours 1compartment NA NA Rat Human -DTXSID1032513 Css NA 0.03432 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032513 Css NA 0.2764 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032513 Css NA 0.03041 mg/L PBTK NA 50% Rat Human -DTXSID1032513 Css NA 0.1823 mg/L PBTK NA 95% Rat Human +DTXSID1032513 TK.Half.Life NA 0.3415 hours 1compartment NA NA Rat Human +DTXSID1032513 Css NA 0.003376 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032513 Css NA 0.03143 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032513 Css NA 0.002848 mg/L PBTK NA 50% Rat Human +DTXSID1032513 Css NA 0.02144 mg/L PBTK NA 95% Rat Human DTXSID1032519 Clint 863 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1032519 Fup 0.0232 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1032519 Vd NA 1.096 L/kg 1compartment NA NA Human Human +DTXSID1032519 Vd NA 0.2829 L/kg 1compartment NA NA Human Human DTXSID1032519 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1032519 TK.Half.Life NA 1.209 hours 1compartment NA NA Human Human -DTXSID1032519 Css NA 0.02399 mg/L 3compartmentss NA 50% Human Human -DTXSID1032519 Css NA 0.194 mg/L 3compartmentss NA 95% Human Human -DTXSID1032519 Css NA 0.01504 mg/L PBTK NA 50% Human Human -DTXSID1032519 Css NA 0.1184 mg/L PBTK NA 95% Human Human +DTXSID1032519 TK.Half.Life NA 0.3268 hours 1compartment NA NA Human Human +DTXSID1032519 Css NA 0.02183 mg/L 3compartmentss NA 50% Human Human +DTXSID1032519 Css NA 0.2108 mg/L 3compartmentss NA 95% Human Human +DTXSID1032519 Css NA 0.01306 mg/L PBTK NA 50% Human Human +DTXSID1032519 Css NA 0.1236 mg/L PBTK NA 95% Human Human DTXSID1032519 Clint 863 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1032519 Fup 0.0232 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1032519 Vd NA 0.8177 L/kg 1compartment NA NA Rat Human +DTXSID1032519 Vd NA 0.2495 L/kg 1compartment NA NA Rat Human DTXSID1032519 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1032519 TK.Half.Life NA 0.4198 hours 1compartment NA NA Rat Human -DTXSID1032519 Css NA 0.01388 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032519 Css NA 0.08987 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032519 Css NA 0.008112 mg/L PBTK NA 50% Rat Human -DTXSID1032519 Css NA 0.05108 mg/L PBTK NA 95% Rat Human +DTXSID1032519 TK.Half.Life NA 0.1385 hours 1compartment NA NA Rat Human +DTXSID1032519 Css NA 0.003108 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032519 Css NA 0.02358 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032519 Css NA 0.001794 mg/L PBTK NA 50% Rat Human +DTXSID1032519 Css NA 0.01342 mg/L PBTK NA 95% Rat Human DTXSID1032569 Clint 22.53 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032569 Fup 0.1633 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032569 Vd NA 0.7722 L/kg 1compartment NA NA Human Human DTXSID1032569 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1032569 TK.Half.Life NA 1.415 hours 1compartment NA NA Human Human -DTXSID1032569 Css NA 0.1449 mg/L 3compartmentss NA 50% Human Human -DTXSID1032569 Css NA 1.037 mg/L 3compartmentss NA 95% Human Human -DTXSID1032569 Css NA 0.09696 mg/L PBTK NA 50% Human Human -DTXSID1032569 Css NA 0.6634 mg/L PBTK NA 95% Human Human +DTXSID1032569 Css NA 0.1402 mg/L 3compartmentss NA 50% Human Human +DTXSID1032569 Css NA 1.044 mg/L 3compartmentss NA 95% Human Human +DTXSID1032569 Css NA 0.09348 mg/L PBTK NA 50% Human Human +DTXSID1032569 Css NA 0.6581 mg/L PBTK NA 95% Human Human DTXSID1032569 Clint 22.53 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1032569 Fup 0.1633 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1032569 Vd NA 0.6525 L/kg 1compartment NA NA Rat Human DTXSID1032569 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1032569 TK.Half.Life NA 0.6589 hours 1compartment NA NA Rat Human -DTXSID1032569 Css NA 0.07985 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032569 Css NA 0.4397 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032569 Css NA 0.05076 mg/L PBTK NA 50% Rat Human -DTXSID1032569 Css NA 0.2698 mg/L PBTK NA 95% Rat Human +DTXSID1032569 Css NA 0.01809 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032569 Css NA 0.1049 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032569 Css NA 0.01186 mg/L PBTK NA 50% Rat Human +DTXSID1032569 Css NA 0.06497 mg/L PBTK NA 95% Rat Human DTXSID1032640 Clint 16.86 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032640 Fup 0.000907 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID1032640 Vd NA 0.7447 L/kg 1compartment NA NA Human Human -DTXSID1032640 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID1032640 TK.Half.Life NA 82.09 hours 1compartment NA NA Human Human -DTXSID1032640 Css NA 20.82 mg/L 3compartmentss NA 50% Human Human -DTXSID1032640 Css NA 162.4 mg/L 3compartmentss NA 95% Human Human -DTXSID1032640 Css NA 12.26 mg/L PBTK NA 50% Human Human -DTXSID1032640 Css NA 95.14 mg/L PBTK NA 95% Human Human +DTXSID1032640 Vd NA 1.927 L/kg 1compartment NA NA Human Human +DTXSID1032640 Days.Css NA 20 Days PBTK NA NA Human Human +DTXSID1032640 TK.Half.Life NA 108.4 hours 1compartment NA NA Human Human +DTXSID1032640 Css NA 9.067 mg/L 3compartmentss NA 50% Human Human +DTXSID1032640 Css NA 63.93 mg/L 3compartmentss NA 95% Human Human +DTXSID1032640 Css NA 5.69 mg/L PBTK NA 50% Human Human +DTXSID1032640 Css NA 39.37 mg/L PBTK NA 95% Human Human DTXSID1032640 Clint 16.86 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1032640 Fup 0.000907 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID1032640 Vd NA 0.5447 L/kg 1compartment NA NA Rat Human -DTXSID1032640 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID1032640 TK.Half.Life NA 38.42 hours 1compartment NA NA Rat Human -DTXSID1032640 Css NA 12.11 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032640 Css NA 71.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032640 Css NA 6.659 mg/L PBTK NA 50% Rat Human -DTXSID1032640 Css NA 38.73 mg/L PBTK NA 95% Rat Human +DTXSID1032640 Vd NA 1.421 L/kg 1compartment NA NA Rat Human +DTXSID1032640 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID1032640 TK.Half.Life NA 35.78 hours 1compartment NA NA Rat Human +DTXSID1032640 Css NA 1.206 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032640 Css NA 6.841 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032640 Css NA 0.736 mg/L PBTK NA 50% Rat Human +DTXSID1032640 Css NA 4.125 mg/L PBTK NA 95% Rat Human DTXSID1032642 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1032642 Fup 0.6278 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID1032642 Vd NA 0.5348 L/kg 1compartment NA NA Human Human +DTXSID1032642 Vd NA 0.536 L/kg 1compartment NA NA Human Human DTXSID1032642 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1032642 TK.Half.Life NA 5.523 hours 1compartment NA NA Human Human -DTXSID1032642 Css NA 1.126 mg/L 3compartmentss NA 50% Human Human -DTXSID1032642 Css NA 7.705 mg/L 3compartmentss NA 95% Human Human -DTXSID1032642 Css NA 0.9588 mg/L PBTK NA 50% Human Human -DTXSID1032642 Css NA 5.032 mg/L PBTK NA 95% Human Human +DTXSID1032642 TK.Half.Life NA 5.536 hours 1compartment NA NA Human Human +DTXSID1032642 Css NA 0.9304 mg/L 3compartmentss NA 50% Human Human +DTXSID1032642 Css NA 5.085 mg/L 3compartmentss NA 95% Human Human +DTXSID1032642 Css NA 0.8157 mg/L PBTK NA 50% Human Human +DTXSID1032642 Css NA 4.458 mg/L PBTK NA 95% Human Human DTXSID1032642 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID1032642 Fup 0.4095 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID1032642 Vd NA 0.4306 L/kg 1compartment NA NA Rat Rat +DTXSID1032642 Vd NA 0.4316 L/kg 1compartment NA NA Rat Rat DTXSID1032642 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID1032642 TK.Half.Life NA 2.319 hours 1compartment NA NA Rat Rat -DTXSID1032642 Css NA 0.4032 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1032642 Css NA 1.74 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1032642 Css NA 0.3435 mg/L PBTK NA 50% Rat Rat -DTXSID1032642 Css NA 1.108 mg/L PBTK NA 95% Rat Rat -DTXSID1032646 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1032646 Fup 5.11e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1032646 Vd NA 8.38 L/kg 1compartment NA NA Human Human -DTXSID1032646 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID1032646 TK.Half.Life NA 542400 hours 1compartment NA NA Human Human -DTXSID1032646 Css NA 8.914 mg/L 3compartmentss NA 50% Human Human -DTXSID1032646 Css NA 57.58 mg/L 3compartmentss NA 95% Human Human -DTXSID1032646 Css NA 9.993 mg/L PBTK NA 50% Human Human -DTXSID1032646 Css NA 63.03 mg/L PBTK NA 95% Human Human -DTXSID1032646 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1032646 Fup 5.11e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1032646 Vd NA 6.549 L/kg 1compartment NA NA Rat Human -DTXSID1032646 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID1032646 TK.Half.Life NA 144400 hours 1compartment NA NA Rat Human -DTXSID1032646 Css NA 4.913 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032646 Css NA 20.98 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032646 Css NA 5.522 mg/L PBTK NA 50% Rat Human -DTXSID1032646 Css NA 23.55 mg/L PBTK NA 95% Rat Human -DTXSID1032648 Clint NA 444.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032648 Fup NA 0.0135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032648 Vd NA 1.326 L/kg 1compartment NA NA Human Human -DTXSID1032648 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1032648 TK.Half.Life NA 1.955 hours 1compartment NA NA Human Human -DTXSID1032648 Css NA 0.09968 mg/L 3compartmentss NA 50% Human Human -DTXSID1032648 Css NA 0.9488 mg/L 3compartmentss NA 95% Human Human -DTXSID1032648 Css NA 0.06144 mg/L PBTK NA 50% Human Human -DTXSID1032648 Css NA 0.5702 mg/L PBTK NA 95% Human Human -DTXSID1032648 Clint NA 444.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032648 Fup NA 0.0135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032648 Vd NA 0.9799 L/kg 1compartment NA NA Rat Human +DTXSID1032642 TK.Half.Life NA 2.324 hours 1compartment NA NA Rat Rat +DTXSID1032642 Css NA 0.03048 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1032642 Css NA 0.1588 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1032642 Css NA 0.0271 mg/L PBTK NA 50% Rat Rat +DTXSID1032642 Css NA 0.1428 mg/L PBTK NA 95% Rat Rat +DTXSID1032648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032648 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032648 Vd NA 1.81 L/kg 1compartment NA NA Human Human +DTXSID1032648 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1032648 TK.Half.Life NA 13.81 hours 1compartment NA NA Human Human +DTXSID1032648 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human +DTXSID1032648 Css NA 9.571 mg/L 3compartmentss NA 95% Human Human +DTXSID1032648 Css NA 0.7096 mg/L PBTK NA 50% Human Human +DTXSID1032648 Css NA 5.797 mg/L PBTK NA 95% Human Human +DTXSID1032648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032648 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032648 Vd NA 1.347 L/kg 1compartment NA NA Rat Human DTXSID1032648 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1032648 TK.Half.Life NA 0.7029 hours 1compartment NA NA Rat Human -DTXSID1032648 Css NA 0.05647 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032648 Css NA 0.4561 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032648 Css NA 0.0325 mg/L PBTK NA 50% Rat Human -DTXSID1032648 Css NA 0.2547 mg/L PBTK NA 95% Rat Human +DTXSID1032648 TK.Half.Life NA 4.8 hours 1compartment NA NA Rat Human +DTXSID1032648 Css NA 0.145 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032648 Css NA 0.9501 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032648 Css NA 0.0901 mg/L PBTK NA 50% Rat Human +DTXSID1032648 Css NA 0.5723 mg/L PBTK NA 95% Rat Human DTXSID1032690 Clint 31.36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID1032690 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1032690 Vd NA 1.551 L/kg 1compartment NA NA Human Human +DTXSID1032690 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1032690 Vd NA 1.755 L/kg 1compartment NA NA Human Human DTXSID1032690 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1032690 TK.Half.Life NA 15.91 hours 1compartment NA NA Human Human -DTXSID1032690 Css NA 1.639 mg/L 3compartmentss NA 50% Human Human -DTXSID1032690 Css NA 14.81 mg/L 3compartmentss NA 95% Human Human -DTXSID1032690 Css NA 1.022 mg/L PBTK NA 50% Human Human -DTXSID1032690 Css NA 9.017 mg/L PBTK NA 95% Human Human +DTXSID1032690 TK.Half.Life NA 15.02 hours 1compartment NA NA Human Human +DTXSID1032690 Css NA 1.273 mg/L 3compartmentss NA 50% Human Human +DTXSID1032690 Css NA 11.43 mg/L 3compartmentss NA 95% Human Human +DTXSID1032690 Css NA 0.7998 mg/L PBTK NA 50% Human Human +DTXSID1032690 Css NA 6.783 mg/L PBTK NA 95% Human Human DTXSID1032690 Clint 31.36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID1032690 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1032690 Vd NA 1.144 L/kg 1compartment NA NA Rat Human +DTXSID1032690 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1032690 Vd NA 1.298 L/kg 1compartment NA NA Rat Human DTXSID1032690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1032690 TK.Half.Life NA 6.017 hours 1compartment NA NA Rat Human -DTXSID1032690 Css NA 0.9306 mg/L 3compartmentss NA 50% Rat Human -DTXSID1032690 Css NA 6.905 mg/L 3compartmentss NA 95% Rat Human -DTXSID1032690 Css NA 0.5438 mg/L PBTK NA 50% Rat Human -DTXSID1032690 Css NA 3.896 mg/L PBTK NA 95% Rat Human -DTXSID1033161 Clint NA 60.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1033161 Fup NA 0.8528 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1033161 Vd NA 0.5491 L/kg 1compartment NA NA Human Human +DTXSID1032690 TK.Half.Life NA 5.303 hours 1compartment NA NA Rat Human +DTXSID1032690 Css NA 0.1686 mg/L 3compartmentss NA 50% Rat Human +DTXSID1032690 Css NA 1.207 mg/L 3compartmentss NA 95% Rat Human +DTXSID1032690 Css NA 0.1036 mg/L PBTK NA 50% Rat Human +DTXSID1032690 Css NA 0.7185 mg/L PBTK NA 95% Rat Human +DTXSID1033161 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1033161 Fup 0.75 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1033161 Vd NA 0.5176 L/kg 1compartment NA NA Human Human DTXSID1033161 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1033161 TK.Half.Life NA 0.383 hours 1compartment NA NA Human Human -DTXSID1033161 Css NA 0.01071 mg/L 3compartmentss NA 50% Human Human -DTXSID1033161 Css NA 0.1128 mg/L 3compartmentss NA 95% Human Human -DTXSID1033161 Css NA 0.008086 mg/L PBTK NA 50% Human Human -DTXSID1033161 Css NA 0.07589 mg/L PBTK NA 95% Human Human -DTXSID1033161 Clint NA 60.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1033161 Fup NA 0.8528 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1033161 Vd NA 0.5622 L/kg 1compartment NA NA Rat Human +DTXSID1033161 TK.Half.Life NA 4.466 hours 1compartment NA NA Human Human +DTXSID1033161 Css NA 1.086 mg/L 3compartmentss NA 50% Human Human +DTXSID1033161 Css NA 6.338 mg/L 3compartmentss NA 95% Human Human +DTXSID1033161 Css NA 0.8268 mg/L PBTK NA 50% Human Human +DTXSID1033161 Css NA 3.898 mg/L PBTK NA 95% Human Human +DTXSID1033161 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1033161 Fup 0.75 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1033161 Vd NA 0.529 L/kg 1compartment NA NA Rat Human DTXSID1033161 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1033161 TK.Half.Life NA 0.1762 hours 1compartment NA NA Rat Human -DTXSID1033161 Css NA 0.005618 mg/L 3compartmentss NA 50% Rat Human -DTXSID1033161 Css NA 0.05177 mg/L 3compartmentss NA 95% Rat Human -DTXSID1033161 Css NA 0.004155 mg/L PBTK NA 50% Rat Human -DTXSID1033161 Css NA 0.03407 mg/L PBTK NA 95% Rat Human -DTXSID1033163 Clint NA 9.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1033163 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1033163 Vd NA 0.2186 L/kg 1compartment NA NA Human Human +DTXSID1033161 TK.Half.Life NA 1.555 hours 1compartment NA NA Rat Human +DTXSID1033161 Css NA 0.06487 mg/L 3compartmentss NA 50% Rat Human +DTXSID1033161 Css NA 0.3698 mg/L 3compartmentss NA 95% Rat Human +DTXSID1033161 Css NA 0.04911 mg/L PBTK NA 50% Rat Human +DTXSID1033161 Css NA 0.223 mg/L PBTK NA 95% Rat Human +DTXSID1033163 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1033163 Fup 0.0398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1033163 Vd NA 0.3343 L/kg 1compartment NA NA Human Human DTXSID1033163 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1033163 TK.Half.Life NA 7.498 hours 1compartment NA NA Human Human -DTXSID1033163 Css NA 6.288 mg/L 3compartmentss NA 50% Human Human -DTXSID1033163 Css NA 57.48 mg/L 3compartmentss NA 95% Human Human -DTXSID1033163 Css NA 3.713 mg/L PBTK NA 50% Human Human -DTXSID1033163 Css NA 33.36 mg/L PBTK NA 95% Human Human -DTXSID1033163 Clint NA 9.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1033163 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1033163 Vd NA 0.2126 L/kg 1compartment NA NA Rat Human +DTXSID1033163 TK.Half.Life NA 5.03 hours 1compartment NA NA Human Human +DTXSID1033163 Css NA 2.556 mg/L 3compartmentss NA 50% Human Human +DTXSID1033163 Css NA 20.86 mg/L 3compartmentss NA 95% Human Human +DTXSID1033163 Css NA 1.573 mg/L PBTK NA 50% Human Human +DTXSID1033163 Css NA 12.35 mg/L PBTK NA 95% Human Human +DTXSID1033163 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1033163 Fup 0.0398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1033163 Vd NA 0.3253 L/kg 1compartment NA NA Rat Human DTXSID1033163 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1033163 TK.Half.Life NA 4.774 hours 1compartment NA NA Rat Human -DTXSID1033163 Css NA 3.487 mg/L 3compartmentss NA 50% Rat Human -DTXSID1033163 Css NA 25.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID1033163 Css NA 1.922 mg/L PBTK NA 50% Rat Human -DTXSID1033163 Css NA 13.75 mg/L PBTK NA 95% Rat Human +DTXSID1033163 TK.Half.Life NA 3.075 hours 1compartment NA NA Rat Human +DTXSID1033163 Css NA 0.3174 mg/L 3compartmentss NA 50% Rat Human +DTXSID1033163 Css NA 2.042 mg/L 3compartmentss NA 95% Rat Human +DTXSID1033163 Css NA 0.189 mg/L PBTK NA 50% Rat Human +DTXSID1033163 Css NA 1.161 mg/L PBTK NA 95% Rat Human DTXSID1033371 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1033371 Fup NA 0.8355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1033371 Vd NA 1.166 L/kg 1compartment NA NA Human Human +DTXSID1033371 Vd NA 1.074 L/kg 1compartment NA NA Human Human DTXSID1033371 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1033371 TK.Half.Life NA 9.458 hours 1compartment NA NA Human Human -DTXSID1033371 Css NA 0.9124 mg/L 3compartmentss NA 50% Human Human -DTXSID1033371 Css NA 5.747 mg/L 3compartmentss NA 95% Human Human -DTXSID1033371 Css NA 0.8132 mg/L PBTK NA 50% Human Human -DTXSID1033371 Css NA 3.775 mg/L PBTK NA 95% Human Human +DTXSID1033371 TK.Half.Life NA 8.576 hours 1compartment NA NA Human Human +DTXSID1033371 Css NA 0.7774 mg/L 3compartmentss NA 50% Human Human +DTXSID1033371 Css NA 4.688 mg/L 3compartmentss NA 95% Human Human +DTXSID1033371 Css NA 0.6861 mg/L PBTK NA 50% Human Human +DTXSID1033371 Css NA 3.091 mg/L PBTK NA 95% Human Human DTXSID1033371 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1033371 Fup NA 0.8355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1033371 Vd NA 1.105 L/kg 1compartment NA NA Rat Human +DTXSID1033371 Vd NA 1.036 L/kg 1compartment NA NA Rat Human DTXSID1033371 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1033371 TK.Half.Life NA 2.95 hours 1compartment NA NA Rat Human -DTXSID1033371 Css NA 0.2329 mg/L 3compartmentss NA 50% Rat Human -DTXSID1033371 Css NA 1.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID1033371 Css NA 0.2034 mg/L PBTK NA 50% Rat Human -DTXSID1033371 Css NA 0.8932 mg/L PBTK NA 95% Rat Human -DTXSID1033402 Clint NA 0.7344 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1033402 Fup NA 0.0278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1033402 Vd NA 0.2494 L/kg 1compartment NA NA Human Human -DTXSID1033402 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1033402 TK.Half.Life NA 25.98 hours 1compartment NA NA Human Human -DTXSID1033402 Css NA 18.04 mg/L 3compartmentss NA 50% Human Human -DTXSID1033402 Css NA 119.9 mg/L 3compartmentss NA 95% Human Human -DTXSID1033402 Css NA 10.64 mg/L PBTK NA 50% Human Human -DTXSID1033402 Css NA 69.51 mg/L PBTK NA 95% Human Human -DTXSID1033402 Clint NA 0.7344 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1033402 Fup NA 0.0278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1033402 Vd NA 0.2255 L/kg 1compartment NA NA Rat Human -DTXSID1033402 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1033402 TK.Half.Life NA 11.17 hours 1compartment NA NA Rat Human -DTXSID1033402 Css NA 7.266 mg/L 3compartmentss NA 50% Rat Human -DTXSID1033402 Css NA 41.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID1033402 Css NA 4.002 mg/L PBTK NA 50% Rat Human -DTXSID1033402 Css NA 22.28 mg/L PBTK NA 95% Rat Human -DTXSID1033539 Clint NA 5.157 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1033539 Fup NA 0.0901 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1033539 Vd NA 2.602 L/kg 1compartment NA NA Human Human -DTXSID1033539 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID1033539 TK.Half.Life NA 47.84 hours 1compartment NA NA Human Human -DTXSID1033539 Css NA 2.447 mg/L 3compartmentss NA 50% Human Human -DTXSID1033539 Css NA 13.42 mg/L 3compartmentss NA 95% Human Human -DTXSID1033539 Css NA 1.679 mg/L PBTK NA 50% Human Human -DTXSID1033539 Css NA 8.841 mg/L PBTK NA 95% Human Human -DTXSID1033539 Clint NA 5.157 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1033539 Fup NA 0.0901 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1033539 Vd NA 1.958 L/kg 1compartment NA NA Rat Human -DTXSID1033539 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID1033539 TK.Half.Life NA 10.64 hours 1compartment NA NA Rat Human -DTXSID1033539 Css NA 1.272 mg/L 3compartmentss NA 50% Rat Human -DTXSID1033539 Css NA 5.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID1033539 Css NA 0.8337 mg/L PBTK NA 50% Rat Human -DTXSID1033539 Css NA 3.13 mg/L PBTK NA 95% Rat Human +DTXSID1033371 TK.Half.Life NA 2.755 hours 1compartment NA NA Rat Human +DTXSID1033371 Css NA 0.01456 mg/L 3compartmentss NA 50% Rat Human +DTXSID1033371 Css NA 0.1128 mg/L 3compartmentss NA 95% Rat Human +DTXSID1033371 Css NA 0.01245 mg/L PBTK NA 50% Rat Human +DTXSID1033371 Css NA 0.07617 mg/L PBTK NA 95% Rat Human +DTXSID1033402 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1033402 Fup 0.0871 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1033402 Vd NA 0.4538 L/kg 1compartment NA NA Human Human +DTXSID1033402 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1033402 TK.Half.Life NA 1.288 hours 1compartment NA NA Human Human +DTXSID1033402 Css NA 0.33 mg/L 3compartmentss NA 50% Human Human +DTXSID1033402 Css NA 2.626 mg/L 3compartmentss NA 95% Human Human +DTXSID1033402 Css NA 0.2048 mg/L PBTK NA 50% Human Human +DTXSID1033402 Css NA 1.583 mg/L PBTK NA 95% Human Human +DTXSID1033402 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1033402 Fup 0.0871 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1033402 Vd NA 0.3859 L/kg 1compartment NA NA Rat Human +DTXSID1033402 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1033402 TK.Half.Life NA 0.6508 hours 1compartment NA NA Rat Human +DTXSID1033402 Css NA 0.04324 mg/L 3compartmentss NA 50% Rat Human +DTXSID1033402 Css NA 0.2704 mg/L 3compartmentss NA 95% Rat Human +DTXSID1033402 Css NA 0.02602 mg/L PBTK NA 50% Rat Human +DTXSID1033402 Css NA 0.1562 mg/L PBTK NA 95% Rat Human +DTXSID1033539 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1033539 Fup 0.0555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1033539 Vd NA 1.823 L/kg 1compartment NA NA Human Human +DTXSID1033539 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1033539 TK.Half.Life NA 8.637 hours 1compartment NA NA Human Human +DTXSID1033539 Css NA 0.6108 mg/L 3compartmentss NA 50% Human Human +DTXSID1033539 Css NA 4.288 mg/L 3compartmentss NA 95% Human Human +DTXSID1033539 Css NA 0.3966 mg/L PBTK NA 50% Human Human +DTXSID1033539 Css NA 2.708 mg/L PBTK NA 95% Human Human +DTXSID1033539 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1033539 Fup 0.0555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1033539 Vd NA 1.369 L/kg 1compartment NA NA Rat Human +DTXSID1033539 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1033539 TK.Half.Life NA 3.014 hours 1compartment NA NA Rat Human +DTXSID1033539 Css NA 0.07856 mg/L 3compartmentss NA 50% Rat Human +DTXSID1033539 Css NA 0.4428 mg/L 3compartmentss NA 95% Rat Human +DTXSID1033539 Css NA 0.04998 mg/L PBTK NA 50% Rat Human +DTXSID1033539 Css NA 0.2704 mg/L PBTK NA 95% Rat Human DTXSID1033664 Clint 12.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1033664 Fup 0.0329 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1033664 Vd NA 1.658 L/kg 1compartment NA NA Human Human DTXSID1033664 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1033664 TK.Half.Life NA 17.48 hours 1compartment NA NA Human Human -DTXSID1033664 Css NA 1.301 mg/L 3compartmentss NA 50% Human Human -DTXSID1033664 Css NA 8.808 mg/L 3compartmentss NA 95% Human Human -DTXSID1033664 Css NA 0.8439 mg/L PBTK NA 50% Human Human -DTXSID1033664 Css NA 5.482 mg/L PBTK NA 95% Human Human +DTXSID1033664 Css NA 1.277 mg/L 3compartmentss NA 50% Human Human +DTXSID1033664 Css NA 8.608 mg/L 3compartmentss NA 95% Human Human +DTXSID1033664 Css NA 0.8266 mg/L PBTK NA 50% Human Human +DTXSID1033664 Css NA 5.466 mg/L PBTK NA 95% Human Human DTXSID1033664 Clint 77.5 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1033664 Fup 0.0191 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1033664 Vd NA 0.9704 L/kg 1compartment NA NA Rat Rat DTXSID1033664 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID1033664 TK.Half.Life NA 1.727 hours 1compartment NA NA Rat Rat -DTXSID1033664 Css NA 0.2458 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1033664 Css NA 1.878 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1033664 Css NA 0.1419 mg/L PBTK NA 50% Rat Rat -DTXSID1033664 Css NA 1.069 mg/L PBTK NA 95% Rat Rat +DTXSID1033664 Css NA 0.0552 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1033664 Css NA 0.4594 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1033664 Css NA 0.03315 mg/L PBTK NA 50% Rat Rat +DTXSID1033664 Css NA 0.2647 mg/L PBTK NA 95% Rat Rat +DTXSID10338220 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10338220 Fup 0.666 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10338220 Vd NA 0.8735 L/kg 1compartment NA NA Human Human +DTXSID10338220 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10338220 TK.Half.Life NA 8.629 hours 1compartment NA NA Human Human +DTXSID10338220 Css NA 1.067 mg/L 3compartmentss NA 50% Human Human +DTXSID10338220 Css NA 7.285 mg/L 3compartmentss NA 95% Human Human +DTXSID10338220 Css NA 0.8949 mg/L PBTK NA 50% Human Human +DTXSID10338220 Css NA 4.568 mg/L PBTK NA 95% Human Human +DTXSID10338220 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10338220 Fup 0.666 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10338220 Vd NA 0.8536 L/kg 1compartment NA NA Rat Human +DTXSID10338220 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10338220 TK.Half.Life NA 2.837 hours 1compartment NA NA Rat Human +DTXSID10338220 Css NA 0.06451 mg/L 3compartmentss NA 50% Rat Human +DTXSID10338220 Css NA 0.4057 mg/L 3compartmentss NA 95% Rat Human +DTXSID10338220 Css NA 0.054 mg/L PBTK NA 50% Rat Human +DTXSID10338220 Css NA 0.2513 mg/L PBTK NA 95% Rat Human DTXSID1034181 Clint 43.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1034181 Fup 0.0129 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1034181 Vd NA 1.875 L/kg 1compartment NA NA Human Human +DTXSID1034181 Vd NA 2.28 L/kg 1compartment NA NA Human Human DTXSID1034181 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1034181 TK.Half.Life NA 7.848 hours 1compartment NA NA Human Human -DTXSID1034181 Css NA 0.4418 mg/L 3compartmentss NA 50% Human Human -DTXSID1034181 Css NA 3.47 mg/L 3compartmentss NA 95% Human Human -DTXSID1034181 Css NA 0.2963 mg/L PBTK NA 50% Human Human -DTXSID1034181 Css NA 2.212 mg/L PBTK NA 95% Human Human +DTXSID1034181 TK.Half.Life NA 8.954 hours 1compartment NA NA Human Human +DTXSID1034181 Css NA 0.3953 mg/L 3compartmentss NA 50% Human Human +DTXSID1034181 Css NA 2.973 mg/L 3compartmentss NA 95% Human Human +DTXSID1034181 Css NA 0.2679 mg/L PBTK NA 50% Human Human +DTXSID1034181 Css NA 1.913 mg/L PBTK NA 95% Human Human DTXSID1034181 Clint 43.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1034181 Fup 0.0129 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1034181 Vd NA 1.478 L/kg 1compartment NA NA Rat Human +DTXSID1034181 Vd NA 1.77 L/kg 1compartment NA NA Rat Human DTXSID1034181 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1034181 TK.Half.Life NA 3.078 hours 1compartment NA NA Rat Human -DTXSID1034181 Css NA 0.2506 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034181 Css NA 1.541 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034181 Css NA 0.1577 mg/L PBTK NA 50% Rat Human -DTXSID1034181 Css NA 0.9405 mg/L PBTK NA 95% Rat Human +DTXSID1034181 TK.Half.Life NA 2.97 hours 1compartment NA NA Rat Human +DTXSID1034181 Css NA 0.05114 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034181 Css NA 0.3331 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034181 Css NA 0.03411 mg/L PBTK NA 50% Rat Human +DTXSID1034181 Css NA 0.2145 mg/L PBTK NA 95% Rat Human DTXSID1034187 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1034187 Fup 0.00165 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1034187 Vd NA 0.9941 L/kg 1compartment NA NA Human Human -DTXSID1034187 Days.Css NA 1129 Days PBTK NA NA Human Human -DTXSID1034187 TK.Half.Life NA 4141 hours 1compartment NA NA Human Human -DTXSID1034187 Css NA 622 mg/L 3compartmentss NA 50% Human Human -DTXSID1034187 Css NA 3646 mg/L 3compartmentss NA 95% Human Human -DTXSID1034187 Css NA 386.2 mg/L PBTK NA 50% Human Human -DTXSID1034187 Css NA 2163 mg/L PBTK NA 95% Human Human +DTXSID1034187 Vd NA 2.849 L/kg 1compartment NA NA Human Human +DTXSID1034187 Days.Css NA 3262 Days PBTK NA NA Human Human +DTXSID1034187 TK.Half.Life NA 11870 hours 1compartment NA NA Human Human +DTXSID1034187 Css NA 537.8 mg/L 3compartmentss NA 50% Human Human +DTXSID1034187 Css NA 3390 mg/L 3compartmentss NA 95% Human Human +DTXSID1034187 Css NA 375.8 mg/L PBTK NA 50% Human Human +DTXSID1034187 Css NA 2084 mg/L PBTK NA 95% Human Human DTXSID1034187 Clint 40.3 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1034187 Fup 0.0094 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID1034187 Vd NA 2.149 L/kg 1compartment NA NA Rat Rat +DTXSID1034187 Vd NA 6.561 L/kg 1compartment NA NA Rat Rat DTXSID1034187 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID1034187 TK.Half.Life NA 1.091 hours 1compartment NA NA Rat Rat -DTXSID1034187 Css NA 0.02658 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1034187 Css NA 0.2341 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1034187 Css NA 0.01856 mg/L PBTK NA 50% Rat Rat -DTXSID1034187 Css NA 0.1433 mg/L PBTK NA 95% Rat Rat +DTXSID1034187 TK.Half.Life NA 2.644 hours 1compartment NA NA Rat Rat +DTXSID1034187 Css NA 0.003749 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1034187 Css NA 0.04429 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1034187 Css NA 0.00418 mg/L PBTK NA 50% Rat Rat +DTXSID1034187 Css NA 0.03463 mg/L PBTK NA 95% Rat Rat DTXSID1034210 Clint 7.216 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID1034210 Fup NA 0.0248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034210 Vd NA 2.493 L/kg 1compartment NA NA Human Human +DTXSID1034210 Fup 0.0184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034210 Vd NA 2.335 L/kg 1compartment NA NA Human Human DTXSID1034210 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID1034210 TK.Half.Life NA 76.13 hours 1compartment NA NA Human Human -DTXSID1034210 Css NA 4.572 mg/L 3compartmentss NA 50% Human Human -DTXSID1034210 Css NA 28.99 mg/L 3compartmentss NA 95% Human Human -DTXSID1034210 Css NA 3.014 mg/L PBTK NA 50% Human Human -DTXSID1034210 Css NA 18.42 mg/L PBTK NA 95% Human Human +DTXSID1034210 TK.Half.Life NA 78.72 hours 1compartment NA NA Human Human +DTXSID1034210 Css NA 4.998 mg/L 3compartmentss NA 50% Human Human +DTXSID1034210 Css NA 37.02 mg/L 3compartmentss NA 95% Human Human +DTXSID1034210 Css NA 3.26 mg/L PBTK NA 50% Human Human +DTXSID1034210 Css NA 23.31 mg/L PBTK NA 95% Human Human DTXSID1034210 Clint 7.216 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID1034210 Fup NA 0.0248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034210 Vd NA 1.861 L/kg 1compartment NA NA Rat Human +DTXSID1034210 Fup 0.0184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034210 Vd NA 1.739 L/kg 1compartment NA NA Rat Human DTXSID1034210 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID1034210 TK.Half.Life NA 18.24 hours 1compartment NA NA Rat Human -DTXSID1034210 Css NA 2.463 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034210 Css NA 12.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034210 Css NA 1.542 mg/L PBTK NA 50% Rat Human -DTXSID1034210 Css NA 7.415 mg/L PBTK NA 95% Rat Human +DTXSID1034210 TK.Half.Life NA 20.78 hours 1compartment NA NA Rat Human +DTXSID1034210 Css NA 0.634 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034210 Css NA 3.399 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034210 Css NA 0.4076 mg/L PBTK NA 50% Rat Human +DTXSID1034210 Css NA 2.078 mg/L PBTK NA 95% Rat Human DTXSID1034212 Clint 3.353 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1034212 Fup 0.005446 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID1034212 Vd NA 0.8195 L/kg 1compartment NA NA Human Human -DTXSID1034212 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID1034212 TK.Half.Life NA 43.57 hours 1compartment NA NA Human Human -DTXSID1034212 Css NA 9.61 mg/L 3compartmentss NA 50% Human Human -DTXSID1034212 Css NA 88.04 mg/L 3compartmentss NA 95% Human Human -DTXSID1034212 Css NA 5.914 mg/L PBTK NA 50% Human Human -DTXSID1034212 Css NA 52.27 mg/L PBTK NA 95% Human Human +DTXSID1034212 Vd NA 0.2941 L/kg 1compartment NA NA Human Human +DTXSID1034212 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID1034212 TK.Half.Life NA 48.27 hours 1compartment NA NA Human Human +DTXSID1034212 Css NA 30.15 mg/L 3compartmentss NA 50% Human Human +DTXSID1034212 Css NA 233 mg/L 3compartmentss NA 95% Human Human +DTXSID1034212 Css NA 17.8 mg/L PBTK NA 50% Human Human +DTXSID1034212 Css NA 136.6 mg/L PBTK NA 95% Human Human DTXSID1034212 Clint 3.353 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1034212 Fup 0.005446 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID1034212 Vd NA 0.7161 L/kg 1compartment NA NA Rat Human -DTXSID1034212 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID1034212 TK.Half.Life NA 24.6 hours 1compartment NA NA Rat Human -DTXSID1034212 Css NA 5.35 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034212 Css NA 39.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034212 Css NA 3.076 mg/L PBTK NA 50% Rat Human -DTXSID1034212 Css NA 21.54 mg/L PBTK NA 95% Rat Human -DTXSID1034214 Clint NA 127.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034214 Fup NA 0.0105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034214 Vd NA 132.4 L/kg 1compartment NA NA Human Human -DTXSID1034214 Days.Css NA 152 Days PBTK NA NA Human Human -DTXSID1034214 TK.Half.Life NA 669.7 hours 1compartment NA NA Human Human -DTXSID1034214 Css NA 0.0251 mg/L 3compartmentss NA 50% Human Human -DTXSID1034214 Css NA 0.1511 mg/L 3compartmentss NA 95% Human Human -DTXSID1034214 Css NA 0.4182 mg/L PBTK NA 50% Human Human -DTXSID1034214 Css NA 2.285 mg/L PBTK NA 95% Human Human -DTXSID1034214 Clint NA 127.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034214 Fup NA 0.0105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034214 Vd NA 115.5 L/kg 1compartment NA NA Rat Human -DTXSID1034214 Days.Css NA 102 Days PBTK NA NA Rat Human -DTXSID1034214 TK.Half.Life NA 102.6 hours 1compartment NA NA Rat Human -DTXSID1034214 Css NA 0.01276 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034214 Css NA 0.05609 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034214 Css NA 0.2246 mg/L PBTK NA 50% Rat Human -DTXSID1034214 Css NA 0.9583 mg/L PBTK NA 95% Rat Human -DTXSID1034260 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1034212 Vd NA 0.2818 L/kg 1compartment NA NA Rat Human +DTXSID1034212 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID1034212 TK.Half.Life NA 28.29 hours 1compartment NA NA Rat Human +DTXSID1034212 Css NA 3.542 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034212 Css NA 22.15 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034212 Css NA 2.012 mg/L PBTK NA 50% Rat Human +DTXSID1034212 Css NA 12.43 mg/L PBTK NA 95% Rat Human +DTXSID1034214 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034214 Fup 0.0282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034214 Vd NA 13.16 L/kg 1compartment NA NA Human Human +DTXSID1034214 Days.Css NA 84 Days PBTK NA NA Human Human +DTXSID1034214 TK.Half.Life NA 390.5 hours 1compartment NA NA Human Human +DTXSID1034214 Css NA 1.602 mg/L 3compartmentss NA 50% Human Human +DTXSID1034214 Css NA 9.743 mg/L 3compartmentss NA 95% Human Human +DTXSID1034214 Css NA 2.354 mg/L PBTK NA 50% Human Human +DTXSID1034214 Css NA 13.82 mg/L PBTK NA 95% Human Human +DTXSID1034214 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034214 Fup 0.0282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034214 Vd NA 10.49 L/kg 1compartment NA NA Rat Human +DTXSID1034214 Days.Css NA 51 Days PBTK NA NA Rat Human +DTXSID1034214 TK.Half.Life NA 53.9 hours 1compartment NA NA Rat Human +DTXSID1034214 Css NA 0.1988 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034214 Css NA 0.9201 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034214 Css NA 0.3054 mg/L PBTK NA 50% Rat Human +DTXSID1034214 Css NA 1.499 mg/L PBTK NA 95% Rat Human +DTXSID1034260 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1034260 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1034260 Vd NA 0.5798 L/kg 1compartment NA NA Human Human DTXSID1034260 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1034260 TK.Half.Life NA 4.171 hours 1compartment NA NA Human Human -DTXSID1034260 Css NA 0.9544 mg/L 3compartmentss NA 50% Human Human -DTXSID1034260 Css NA 3.593 mg/L 3compartmentss NA 95% Human Human -DTXSID1034260 Css NA 0.7365 mg/L PBTK NA 50% Human Human -DTXSID1034260 Css NA 2.395 mg/L PBTK NA 95% Human Human -DTXSID1034260 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1034260 Css NA 0.8102 mg/L 3compartmentss NA 50% Human Human +DTXSID1034260 Css NA 3.101 mg/L 3compartmentss NA 95% Human Human +DTXSID1034260 Css NA 0.6276 mg/L PBTK NA 50% Human Human +DTXSID1034260 Css NA 2.06 mg/L PBTK NA 95% Human Human +DTXSID1034260 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1034260 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1034260 Vd NA 0.6065 L/kg 1compartment NA NA Rat Human DTXSID1034260 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1034260 TK.Half.Life NA 1.486 hours 1compartment NA NA Rat Human -DTXSID1034260 Css NA 0.2472 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034260 Css NA 0.8739 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034260 Css NA 0.1853 mg/L PBTK NA 50% Rat Human -DTXSID1034260 Css NA 0.5353 mg/L PBTK NA 95% Rat Human -DTXSID1034266 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034266 Fup NA 0.984 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034266 Vd NA 1.883 L/kg 1compartment NA NA Human Human -DTXSID1034266 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1034266 TK.Half.Life NA 12.38 hours 1compartment NA NA Human Human -DTXSID1034266 Css NA 0.722 mg/L 3compartmentss NA 50% Human Human -DTXSID1034266 Css NA 4.694 mg/L 3compartmentss NA 95% Human Human -DTXSID1034266 Css NA 0.7267 mg/L PBTK NA 50% Human Human -DTXSID1034266 Css NA 3.308 mg/L PBTK NA 95% Human Human -DTXSID1034266 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034266 Fup NA 0.984 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034266 Vd NA 1.943 L/kg 1compartment NA NA Rat Human +DTXSID1034260 Css NA 0.01468 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034260 Css NA 0.07829 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034260 Css NA 0.011 mg/L PBTK NA 50% Rat Human +DTXSID1034260 Css NA 0.05263 mg/L PBTK NA 95% Rat Human +DTXSID1034266 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034266 Fup 0.828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034266 Vd NA 0.4865 L/kg 1compartment NA NA Human Human +DTXSID1034266 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1034266 TK.Half.Life NA 3.802 hours 1compartment NA NA Human Human +DTXSID1034266 Css NA 1.05 mg/L 3compartmentss NA 50% Human Human +DTXSID1034266 Css NA 5.893 mg/L 3compartmentss NA 95% Human Human +DTXSID1034266 Css NA 0.7786 mg/L PBTK NA 50% Human Human +DTXSID1034266 Css NA 3.703 mg/L PBTK NA 95% Human Human +DTXSID1034266 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034266 Fup 0.828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034266 Vd NA 0.5082 L/kg 1compartment NA NA Rat Human DTXSID1034266 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1034266 TK.Half.Life NA 4.354 hours 1compartment NA NA Rat Human -DTXSID1034266 Css NA 0.1809 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034266 Css NA 1.185 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034266 Css NA 0.1802 mg/L PBTK NA 50% Rat Human -DTXSID1034266 Css NA 0.7671 mg/L PBTK NA 95% Rat Human -DTXSID1034501 Clint NA 91.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034501 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034501 Vd NA 11.11 L/kg 1compartment NA NA Human Human -DTXSID1034501 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID1034501 TK.Half.Life NA 84.15 hours 1compartment NA NA Human Human -DTXSID1034501 Css NA 0.4648 mg/L 3compartmentss NA 50% Human Human -DTXSID1034501 Css NA 2.766 mg/L 3compartmentss NA 95% Human Human -DTXSID1034501 Css NA 0.5972 mg/L PBTK NA 50% Human Human -DTXSID1034501 Css NA 3.38 mg/L PBTK NA 95% Human Human -DTXSID1034501 Clint NA 91.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034501 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034501 Vd NA 8.79 L/kg 1compartment NA NA Rat Human -DTXSID1034501 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID1034501 TK.Half.Life NA 13.11 hours 1compartment NA NA Rat Human -DTXSID1034501 Css NA 0.2526 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034501 Css NA 1.057 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034501 Css NA 0.324 mg/L PBTK NA 50% Rat Human -DTXSID1034501 Css NA 1.378 mg/L PBTK NA 95% Rat Human -DTXSID1034503 Clint NA 138.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034503 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034503 Vd NA 1.231 L/kg 1compartment NA NA Human Human +DTXSID1034266 TK.Half.Life NA 1.353 hours 1compartment NA NA Rat Human +DTXSID1034266 Css NA 0.06285 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034266 Css NA 0.3342 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034266 Css NA 0.04643 mg/L PBTK NA 50% Rat Human +DTXSID1034266 Css NA 0.2009 mg/L PBTK NA 95% Rat Human +DTXSID1034501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034501 Fup 0.00837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034501 Vd NA 11.22 L/kg 1compartment NA NA Human Human +DTXSID1034501 Days.Css NA 71 Days PBTK NA NA Human Human +DTXSID1034501 TK.Half.Life NA 337.1 hours 1compartment NA NA Human Human +DTXSID1034501 Css NA 1.862 mg/L 3compartmentss NA 50% Human Human +DTXSID1034501 Css NA 11.5 mg/L 3compartmentss NA 95% Human Human +DTXSID1034501 Css NA 2.4 mg/L PBTK NA 50% Human Human +DTXSID1034501 Css NA 14.4 mg/L PBTK NA 95% Human Human +DTXSID1034501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034501 Fup 0.00837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034501 Vd NA 8.875 L/kg 1compartment NA NA Rat Human +DTXSID1034501 Days.Css NA 43 Days PBTK NA NA Rat Human +DTXSID1034501 TK.Half.Life NA 47.87 hours 1compartment NA NA Rat Human +DTXSID1034501 Css NA 0.2317 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034501 Css NA 1.119 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034501 Css NA 0.3115 mg/L PBTK NA 50% Rat Human +DTXSID1034501 Css NA 1.605 mg/L PBTK NA 95% Rat Human +DTXSID1034503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034503 Fup 0.0364 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034503 Vd NA 1.654 L/kg 1compartment NA NA Human Human DTXSID1034503 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1034503 TK.Half.Life NA 2.796 hours 1compartment NA NA Human Human -DTXSID1034503 Css NA 0.2451 mg/L 3compartmentss NA 50% Human Human -DTXSID1034503 Css NA 2.429 mg/L 3compartmentss NA 95% Human Human -DTXSID1034503 Css NA 0.1514 mg/L PBTK NA 50% Human Human -DTXSID1034503 Css NA 1.449 mg/L PBTK NA 95% Human Human -DTXSID1034503 Clint NA 138.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034503 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034503 Vd NA 0.9135 L/kg 1compartment NA NA Rat Human +DTXSID1034503 TK.Half.Life NA 10.15 hours 1compartment NA NA Human Human +DTXSID1034503 Css NA 0.8852 mg/L 3compartmentss NA 50% Human Human +DTXSID1034503 Css NA 7.136 mg/L 3compartmentss NA 95% Human Human +DTXSID1034503 Css NA 0.5648 mg/L PBTK NA 50% Human Human +DTXSID1034503 Css NA 4.349 mg/L PBTK NA 95% Human Human +DTXSID1034503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034503 Fup 0.0364 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034503 Vd NA 1.235 L/kg 1compartment NA NA Rat Human DTXSID1034503 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1034503 TK.Half.Life NA 1.087 hours 1compartment NA NA Rat Human -DTXSID1034503 Css NA 0.139 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034503 Css NA 1.195 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034503 Css NA 0.08031 mg/L PBTK NA 50% Rat Human -DTXSID1034503 Css NA 0.6643 mg/L PBTK NA 95% Rat Human +DTXSID1034503 TK.Half.Life NA 3.733 hours 1compartment NA NA Rat Human +DTXSID1034503 Css NA 0.118 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034503 Css NA 0.6903 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034503 Css NA 0.07303 mg/L PBTK NA 50% Rat Human +DTXSID1034503 Css NA 0.4155 mg/L PBTK NA 95% Rat Human DTXSID1034634 Clint 26.87 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1034634 Fup 0.02755 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID1034634 Vd NA 1.319 L/kg 1compartment NA NA Human Human DTXSID1034634 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1034634 TK.Half.Life NA 7.821 hours 1compartment NA NA Human Human -DTXSID1034634 Css NA 0.8984 mg/L 3compartmentss NA 50% Human Human -DTXSID1034634 Css NA 8.145 mg/L 3compartmentss NA 95% Human Human -DTXSID1034634 Css NA 0.5594 mg/L PBTK NA 50% Human Human -DTXSID1034634 Css NA 4.859 mg/L PBTK NA 95% Human Human +DTXSID1034634 Css NA 0.8822 mg/L 3compartmentss NA 50% Human Human +DTXSID1034634 Css NA 7.729 mg/L 3compartmentss NA 95% Human Human +DTXSID1034634 Css NA 0.547 mg/L PBTK NA 50% Human Human +DTXSID1034634 Css NA 4.633 mg/L PBTK NA 95% Human Human DTXSID1034634 Clint 26.87 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1034634 Fup 0.02755 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID1034634 Vd NA 0.9837 L/kg 1compartment NA NA Rat Human DTXSID1034634 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1034634 TK.Half.Life NA 3.164 hours 1compartment NA NA Rat Human -DTXSID1034634 Css NA 0.5049 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034634 Css NA 3.761 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034634 Css NA 0.2946 mg/L PBTK NA 50% Rat Human -DTXSID1034634 Css NA 2.098 mg/L PBTK NA 95% Rat Human -DTXSID1034769 Clint NA 8.275 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034769 Fup NA 0.0546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034769 Vd NA 1.307 L/kg 1compartment NA NA Human Human -DTXSID1034769 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1034769 TK.Half.Life NA 12.27 hours 1compartment NA NA Human Human -DTXSID1034769 Css NA 1.484 mg/L 3compartmentss NA 50% Human Human -DTXSID1034769 Css NA 9.575 mg/L 3compartmentss NA 95% Human Human -DTXSID1034769 Css NA 0.9434 mg/L PBTK NA 50% Human Human -DTXSID1034769 Css NA 5.823 mg/L PBTK NA 95% Human Human -DTXSID1034769 Clint NA 8.275 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034769 Fup NA 0.0546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034769 Vd NA 0.9885 L/kg 1compartment NA NA Rat Human +DTXSID1034634 Css NA 0.1146 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034634 Css NA 0.8638 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034634 Css NA 0.06953 mg/L PBTK NA 50% Rat Human +DTXSID1034634 Css NA 0.5029 mg/L PBTK NA 95% Rat Human +DTXSID1034769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034769 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034769 Vd NA 1.416 L/kg 1compartment NA NA Human Human +DTXSID1034769 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1034769 TK.Half.Life NA 3.879 hours 1compartment NA NA Human Human +DTXSID1034769 Css NA 0.2958 mg/L 3compartmentss NA 50% Human Human +DTXSID1034769 Css NA 2.206 mg/L 3compartmentss NA 95% Human Human +DTXSID1034769 Css NA 0.1952 mg/L PBTK NA 50% Human Human +DTXSID1034769 Css NA 1.384 mg/L PBTK NA 95% Human Human +DTXSID1034769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034769 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034769 Vd NA 1.088 L/kg 1compartment NA NA Rat Human DTXSID1034769 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1034769 TK.Half.Life NA 4.965 hours 1compartment NA NA Rat Human -DTXSID1034769 Css NA 0.7839 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034769 Css NA 4.003 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034769 Css NA 0.4678 mg/L PBTK NA 50% Rat Human -DTXSID1034769 Css NA 2.297 mg/L PBTK NA 95% Rat Human -DTXSID1034844 Clint NA 9.781 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034844 Fup NA 0.1829 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034844 Vd NA 1.045 L/kg 1compartment NA NA Human Human -DTXSID1034844 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1034844 TK.Half.Life NA 3.022 hours 1compartment NA NA Human Human -DTXSID1034844 Css NA 0.2758 mg/L 3compartmentss NA 50% Human Human -DTXSID1034844 Css NA 1.678 mg/L 3compartmentss NA 95% Human Human -DTXSID1034844 Css NA 0.1926 mg/L PBTK NA 50% Human Human -DTXSID1034844 Css NA 1.102 mg/L PBTK NA 95% Human Human -DTXSID1034844 Clint NA 9.781 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034844 Fup NA 0.1829 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034844 Vd NA 0.8518 L/kg 1compartment NA NA Rat Human -DTXSID1034844 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1034844 TK.Half.Life NA 1.359 hours 1compartment NA NA Rat Human -DTXSID1034844 Css NA 0.1451 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034844 Css NA 0.6513 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034844 Css NA 0.0966 mg/L PBTK NA 50% Rat Human -DTXSID1034844 Css NA 0.4068 mg/L PBTK NA 95% Rat Human -DTXSID1034929 Clint NA 140 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034929 Fup NA 0.0095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1034929 Vd NA 2.517 L/kg 1compartment NA NA Human Human -DTXSID1034929 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1034929 TK.Half.Life NA 8.966 hours 1compartment NA NA Human Human -DTXSID1034929 Css NA 0.412 mg/L 3compartmentss NA 50% Human Human -DTXSID1034929 Css NA 3.19 mg/L 3compartmentss NA 95% Human Human -DTXSID1034929 Css NA 0.2706 mg/L PBTK NA 50% Human Human -DTXSID1034929 Css NA 2.011 mg/L PBTK NA 95% Human Human -DTXSID1034929 Clint NA 140 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034929 Fup NA 0.0095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1034929 Vd NA 1.875 L/kg 1compartment NA NA Rat Human -DTXSID1034929 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1034929 TK.Half.Life NA 2.332 hours 1compartment NA NA Rat Human -DTXSID1034929 Css NA 0.2344 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034929 Css NA 1.473 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034929 Css NA 0.1466 mg/L PBTK NA 50% Rat Human -DTXSID1034929 Css NA 0.8765 mg/L PBTK NA 95% Rat Human +DTXSID1034769 TK.Half.Life NA 1.536 hours 1compartment NA NA Rat Human +DTXSID1034769 Css NA 0.03764 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034769 Css NA 0.2272 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034769 Css NA 0.02432 mg/L PBTK NA 50% Rat Human +DTXSID1034769 Css NA 0.1389 mg/L PBTK NA 95% Rat Human +DTXSID1034844 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034844 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034844 Vd NA 1.336 L/kg 1compartment NA NA Human Human +DTXSID1034844 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1034844 TK.Half.Life NA 35.75 hours 1compartment NA NA Human Human +DTXSID1034844 Css NA 2.83 mg/L 3compartmentss NA 50% Human Human +DTXSID1034844 Css NA 10.66 mg/L 3compartmentss NA 95% Human Human +DTXSID1034844 Css NA 2.128 mg/L PBTK NA 50% Human Human +DTXSID1034844 Css NA 7.052 mg/L PBTK NA 95% Human Human +DTXSID1034844 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034844 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034844 Vd NA 1.094 L/kg 1compartment NA NA Rat Human +DTXSID1034844 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1034844 TK.Half.Life NA 8.67 hours 1compartment NA NA Rat Human +DTXSID1034844 Css NA 0.1797 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034844 Css NA 0.5668 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034844 Css NA 0.1345 mg/L PBTK NA 50% Rat Human +DTXSID1034844 Css NA 0.3572 mg/L PBTK NA 95% Rat Human +DTXSID1034925 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034925 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034925 Vd NA 0.3892 L/kg 1compartment NA NA Human Human +DTXSID1034925 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1034925 TK.Half.Life NA 5.336 hours 1compartment NA NA Human Human +DTXSID1034925 Css NA 1.383 mg/L 3compartmentss NA 50% Human Human +DTXSID1034925 Css NA 6.39 mg/L 3compartmentss NA 95% Human Human +DTXSID1034925 Css NA 0.9732 mg/L PBTK NA 50% Human Human +DTXSID1034925 Css NA 3.95 mg/L PBTK NA 95% Human Human +DTXSID1034925 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034925 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034925 Vd NA 0.4022 L/kg 1compartment NA NA Rat Human +DTXSID1034925 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1034925 TK.Half.Life NA 1.878 hours 1compartment NA NA Rat Human +DTXSID1034925 Css NA 0.02568 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034925 Css NA 0.1701 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034925 Css NA 0.01747 mg/L PBTK NA 50% Rat Human +DTXSID1034925 Css NA 0.1046 mg/L PBTK NA 95% Rat Human +DTXSID1034929 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034929 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1034929 Vd NA 37.59 L/kg 1compartment NA NA Human Human +DTXSID1034929 Days.Css NA 274 Days PBTK NA NA Human Human +DTXSID1034929 TK.Half.Life NA 1113 hours 1compartment NA NA Human Human +DTXSID1034929 Css NA 0.5912 mg/L 3compartmentss NA 50% Human Human +DTXSID1034929 Css NA 3.699 mg/L 3compartmentss NA 95% Human Human +DTXSID1034929 Css NA 2.387 mg/L PBTK NA 50% Human Human +DTXSID1034929 Css NA 14.23 mg/L PBTK NA 95% Human Human +DTXSID1034929 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034929 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1034929 Vd NA 31.34 L/kg 1compartment NA NA Rat Human +DTXSID1034929 Days.Css NA 169 Days PBTK NA NA Rat Human +DTXSID1034929 TK.Half.Life NA 161.9 hours 1compartment NA NA Rat Human +DTXSID1034929 Css NA 0.07004 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034929 Css NA 0.3246 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034929 Css NA 0.3083 mg/L PBTK NA 50% Rat Human +DTXSID1034929 Css NA 1.517 mg/L PBTK NA 95% Rat Human DTXSID1034973 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1034973 Fup 0.169 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1034973 Vd NA 3.095 L/kg 1compartment NA NA Human Human -DTXSID1034973 Days.Css NA 651 Days PBTK NA NA Human Human +DTXSID1034973 Days.Css NA 1122 Days PBTK NA NA Human Human DTXSID1034973 TK.Half.Life NA 4141 hours 1compartment NA NA Human Human -DTXSID1034973 Css NA 148.2 mg/L 3compartmentss NA 50% Human Human -DTXSID1034973 Css NA 413.7 mg/L 3compartmentss NA 95% Human Human -DTXSID1034973 Css NA 104.6 mg/L PBTK NA 50% Human Human -DTXSID1034973 Css NA 270.2 mg/L PBTK NA 95% Human Human +DTXSID1034973 Css NA 145.8 mg/L 3compartmentss NA 50% Human Human +DTXSID1034973 Css NA 398.7 mg/L 3compartmentss NA 95% Human Human +DTXSID1034973 Css NA 102.8 mg/L PBTK NA 50% Human Human +DTXSID1034973 Css NA 262.5 mg/L PBTK NA 95% Human Human DTXSID1034973 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1034973 Fup 0.169 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1034973 Vd NA 2.324 L/kg 1compartment NA NA Rat Human -DTXSID1034973 Days.Css NA 283 Days PBTK NA NA Rat Human +DTXSID1034973 Days.Css NA 282 Days PBTK NA NA Rat Human DTXSID1034973 TK.Half.Life NA 275.6 hours 1compartment NA NA Rat Human -DTXSID1034973 Css NA 40.52 mg/L 3compartmentss NA 50% Rat Human -DTXSID1034973 Css NA 88.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID1034973 Css NA 27.34 mg/L PBTK NA 50% Rat Human -DTXSID1034973 Css NA 54.07 mg/L PBTK NA 95% Rat Human -DTXSID1035286 Clint NA 2.415 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1035286 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1035286 Vd NA 5.664 L/kg 1compartment NA NA Human Human -DTXSID1035286 Days.Css NA 382 Days PBTK NA NA Human Human -DTXSID1035286 TK.Half.Life NA 1491 hours 1compartment NA NA Human Human -DTXSID1035286 Css NA 25.62 mg/L 3compartmentss NA 50% Human Human -DTXSID1035286 Css NA 139.4 mg/L 3compartmentss NA 95% Human Human -DTXSID1035286 Css NA 21.92 mg/L PBTK NA 50% Human Human -DTXSID1035286 Css NA 117.2 mg/L PBTK NA 95% Human Human -DTXSID1035286 Clint NA 2.415 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1035286 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1035286 Vd NA 4.349 L/kg 1compartment NA NA Rat Human -DTXSID1035286 Days.Css NA 210 Days PBTK NA NA Rat Human -DTXSID1035286 TK.Half.Life NA 195.4 hours 1compartment NA NA Rat Human -DTXSID1035286 Css NA 14.01 mg/L 3compartmentss NA 50% Rat Human -DTXSID1035286 Css NA 56.66 mg/L 3compartmentss NA 95% Rat Human -DTXSID1035286 Css NA 11.68 mg/L PBTK NA 50% Rat Human -DTXSID1035286 Css NA 47.41 mg/L PBTK NA 95% Rat Human -DTXSID1035288 Clint NA 50.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1035288 Fup NA 0.0979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1035288 Vd NA 2.92 L/kg 1compartment NA NA Human Human -DTXSID1035288 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1035288 TK.Half.Life NA 11.28 hours 1compartment NA NA Human Human -DTXSID1035288 Css NA 0.4046 mg/L 3compartmentss NA 50% Human Human -DTXSID1035288 Css NA 2.53 mg/L 3compartmentss NA 95% Human Human -DTXSID1035288 Css NA 0.2808 mg/L PBTK NA 50% Human Human -DTXSID1035288 Css NA 1.698 mg/L PBTK NA 95% Human Human -DTXSID1035288 Clint NA 50.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1035288 Fup NA 0.0979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1035288 Vd NA 2.194 L/kg 1compartment NA NA Rat Human -DTXSID1035288 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1035288 TK.Half.Life NA 2.297 hours 1compartment NA NA Rat Human -DTXSID1035288 Css NA 0.2228 mg/L 3compartmentss NA 50% Rat Human -DTXSID1035288 Css NA 1.205 mg/L 3compartmentss NA 95% Rat Human -DTXSID1035288 Css NA 0.1481 mg/L PBTK NA 50% Rat Human -DTXSID1035288 Css NA 0.7741 mg/L PBTK NA 95% Rat Human -DTXSID1035783 Clint NA 95.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1035783 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1035783 Vd NA 3.082 L/kg 1compartment NA NA Human Human -DTXSID1035783 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1035783 TK.Half.Life NA 20.42 hours 1compartment NA NA Human Human -DTXSID1035783 Css NA 0.733 mg/L 3compartmentss NA 50% Human Human -DTXSID1035783 Css NA 4.752 mg/L 3compartmentss NA 95% Human Human -DTXSID1035783 Css NA 0.5094 mg/L PBTK NA 50% Human Human -DTXSID1035783 Css NA 3.188 mg/L PBTK NA 95% Human Human -DTXSID1035783 Clint NA 95.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1035783 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1035783 Vd NA 2.308 L/kg 1compartment NA NA Rat Human -DTXSID1035783 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1035783 TK.Half.Life NA 3.271 hours 1compartment NA NA Rat Human -DTXSID1035783 Css NA 0.4146 mg/L 3compartmentss NA 50% Rat Human -DTXSID1035783 Css NA 2.183 mg/L 3compartmentss NA 95% Rat Human -DTXSID1035783 Css NA 0.2734 mg/L PBTK NA 50% Rat Human -DTXSID1035783 Css NA 1.375 mg/L PBTK NA 95% Rat Human -DTXSID1036541 Clint NA 39.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1036541 Fup NA 0.0534 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1036541 Vd NA 2.875 L/kg 1compartment NA NA Human Human -DTXSID1036541 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1036541 TK.Half.Life NA 17.48 hours 1compartment NA NA Human Human -DTXSID1036541 Css NA 0.7044 mg/L 3compartmentss NA 50% Human Human -DTXSID1036541 Css NA 4.551 mg/L 3compartmentss NA 95% Human Human -DTXSID1036541 Css NA 0.485 mg/L PBTK NA 50% Human Human -DTXSID1036541 Css NA 3.008 mg/L PBTK NA 95% Human Human -DTXSID1036541 Clint NA 39.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1036541 Fup NA 0.0534 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1036541 Vd NA 2.156 L/kg 1compartment NA NA Rat Human -DTXSID1036541 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1036541 TK.Half.Life NA 3.459 hours 1compartment NA NA Rat Human -DTXSID1036541 Css NA 0.3966 mg/L 3compartmentss NA 50% Rat Human -DTXSID1036541 Css NA 2.155 mg/L 3compartmentss NA 95% Rat Human -DTXSID1036541 Css NA 0.2599 mg/L PBTK NA 50% Rat Human -DTXSID1036541 Css NA 1.363 mg/L PBTK NA 95% Rat Human -DTXSID1036545 Clint NA 12.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1036545 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1036545 Vd NA 1.186 L/kg 1compartment NA NA Human Human -DTXSID1036545 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1036545 TK.Half.Life NA 20.94 hours 1compartment NA NA Human Human -DTXSID1036545 Css NA 3.02 mg/L 3compartmentss NA 50% Human Human -DTXSID1036545 Css NA 26.78 mg/L 3compartmentss NA 95% Human Human -DTXSID1036545 Css NA 1.868 mg/L PBTK NA 50% Human Human -DTXSID1036545 Css NA 15.88 mg/L PBTK NA 95% Human Human -DTXSID1036545 Clint NA 12.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1036545 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1036545 Vd NA 0.8794 L/kg 1compartment NA NA Rat Human -DTXSID1036545 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1036545 TK.Half.Life NA 8.762 hours 1compartment NA NA Rat Human -DTXSID1036545 Css NA 1.672 mg/L 3compartmentss NA 50% Rat Human -DTXSID1036545 Css NA 11.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID1036545 Css NA 0.9699 mg/L PBTK NA 50% Rat Human -DTXSID1036545 Css NA 6.31 mg/L PBTK NA 95% Rat Human +DTXSID1034973 Css NA 9.205 mg/L 3compartmentss NA 50% Rat Human +DTXSID1034973 Css NA 20.34 mg/L 3compartmentss NA 95% Rat Human +DTXSID1034973 Css NA 6.428 mg/L PBTK NA 50% Rat Human +DTXSID1034973 Css NA 12.79 mg/L PBTK NA 95% Rat Human +DTXSID1035288 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1035288 Fup 0.056 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1035288 Vd NA 2.971 L/kg 1compartment NA NA Human Human +DTXSID1035288 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1035288 TK.Half.Life NA 36.71 hours 1compartment NA NA Human Human +DTXSID1035288 Css NA 1.473 mg/L 3compartmentss NA 50% Human Human +DTXSID1035288 Css NA 9.332 mg/L 3compartmentss NA 95% Human Human +DTXSID1035288 Css NA 1.019 mg/L PBTK NA 50% Human Human +DTXSID1035288 Css NA 6.255 mg/L PBTK NA 95% Human Human +DTXSID1035288 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1035288 Fup 0.056 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1035288 Vd NA 2.228 L/kg 1compartment NA NA Rat Human +DTXSID1035288 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1035288 TK.Half.Life NA 6.222 hours 1compartment NA NA Rat Human +DTXSID1035288 Css NA 0.1884 mg/L 3compartmentss NA 50% Rat Human +DTXSID1035288 Css NA 1.054 mg/L 3compartmentss NA 95% Rat Human +DTXSID1035288 Css NA 0.1294 mg/L PBTK NA 50% Rat Human +DTXSID1035288 Css NA 0.7043 mg/L PBTK NA 95% Rat Human +DTXSID1035783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1035783 Fup 0.0265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1035783 Vd NA 3.107 L/kg 1compartment NA NA Human Human +DTXSID1035783 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID1035783 TK.Half.Life NA 81.36 hours 1compartment NA NA Human Human +DTXSID1035783 Css NA 3.134 mg/L 3compartmentss NA 50% Human Human +DTXSID1035783 Css NA 19.65 mg/L 3compartmentss NA 95% Human Human +DTXSID1035783 Css NA 2.163 mg/L PBTK NA 50% Human Human +DTXSID1035783 Css NA 13.42 mg/L PBTK NA 95% Human Human +DTXSID1035783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1035783 Fup 0.0265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1035783 Vd NA 2.328 L/kg 1compartment NA NA Rat Human +DTXSID1035783 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID1035783 TK.Half.Life NA 11.2 hours 1compartment NA NA Rat Human +DTXSID1035783 Css NA 0.4027 mg/L 3compartmentss NA 50% Rat Human +DTXSID1035783 Css NA 2.242 mg/L 3compartmentss NA 95% Rat Human +DTXSID1035783 Css NA 0.2774 mg/L PBTK NA 50% Rat Human +DTXSID1035783 Css NA 1.506 mg/L PBTK NA 95% Rat Human +DTXSID10359814 Clint 47.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10359814 Fup 0.021 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10359814 Vd NA 1.467 L/kg 1compartment NA NA Human Human +DTXSID10359814 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10359814 TK.Half.Life NA 4.557 hours 1compartment NA NA Human Human +DTXSID10359814 Css NA 0.3747 mg/L 3compartmentss NA 50% Human Human +DTXSID10359814 Css NA 3.95 mg/L 3compartmentss NA 95% Human Human +DTXSID10359814 Css NA 0.246 mg/L PBTK NA 50% Human Human +DTXSID10359814 Css NA 2.422 mg/L PBTK NA 95% Human Human +DTXSID10359814 Clint 47.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10359814 Fup 0.021 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10359814 Vd NA 1.259 L/kg 1compartment NA NA Rat Human +DTXSID10359814 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10359814 TK.Half.Life NA 2.229 hours 1compartment NA NA Rat Human +DTXSID10359814 Css NA 0.04986 mg/L 3compartmentss NA 50% Rat Human +DTXSID10359814 Css NA 0.4236 mg/L 3compartmentss NA 95% Rat Human +DTXSID10359814 Css NA 0.03226 mg/L PBTK NA 50% Rat Human +DTXSID10359814 Css NA 0.2503 mg/L PBTK NA 95% Rat Human +DTXSID1036541 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1036541 Fup 0.0587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1036541 Vd NA 2.899 L/kg 1compartment NA NA Human Human +DTXSID1036541 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1036541 TK.Half.Life NA 29.75 hours 1compartment NA NA Human Human +DTXSID1036541 Css NA 1.236 mg/L 3compartmentss NA 50% Human Human +DTXSID1036541 Css NA 7.73 mg/L 3compartmentss NA 95% Human Human +DTXSID1036541 Css NA 0.8467 mg/L PBTK NA 50% Human Human +DTXSID1036541 Css NA 5.069 mg/L PBTK NA 95% Human Human +DTXSID1036541 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1036541 Fup 0.0587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1036541 Vd NA 2.175 L/kg 1compartment NA NA Rat Human +DTXSID1036541 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1036541 TK.Half.Life NA 5.497 hours 1compartment NA NA Rat Human +DTXSID1036541 Css NA 0.1577 mg/L 3compartmentss NA 50% Rat Human +DTXSID1036541 Css NA 0.8693 mg/L 3compartmentss NA 95% Rat Human +DTXSID1036541 Css NA 0.1074 mg/L PBTK NA 50% Rat Human +DTXSID1036541 Css NA 0.5785 mg/L PBTK NA 95% Rat Human +DTXSID1036545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1036545 Fup 0.0237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1036545 Vd NA 1.817 L/kg 1compartment NA NA Human Human +DTXSID1036545 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1036545 TK.Half.Life NA 15.75 hours 1compartment NA NA Human Human +DTXSID1036545 Css NA 1.26 mg/L 3compartmentss NA 50% Human Human +DTXSID1036545 Css NA 10.92 mg/L 3compartmentss NA 95% Human Human +DTXSID1036545 Css NA 0.8158 mg/L PBTK NA 50% Human Human +DTXSID1036545 Css NA 6.784 mg/L PBTK NA 95% Human Human +DTXSID1036545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1036545 Fup 0.0237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1036545 Vd NA 1.353 L/kg 1compartment NA NA Rat Human +DTXSID1036545 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1036545 TK.Half.Life NA 5.454 hours 1compartment NA NA Rat Human +DTXSID1036545 Css NA 0.1648 mg/L 3compartmentss NA 50% Rat Human +DTXSID1036545 Css NA 1.136 mg/L 3compartmentss NA 95% Rat Human +DTXSID1036545 Css NA 0.1036 mg/L PBTK NA 50% Rat Human +DTXSID1036545 Css NA 0.6826 mg/L PBTK NA 95% Rat Human DTXSID1037197 Clint 57.11 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1037197 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1037197 Vd NA 0.7477 L/kg 1compartment NA NA Human Human DTXSID1037197 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1037197 TK.Half.Life NA 0.5059 hours 1compartment NA NA Human Human -DTXSID1037197 Css NA 0.01117 mg/L 3compartmentss NA 50% Human Human -DTXSID1037197 Css NA 0.1198 mg/L 3compartmentss NA 95% Human Human -DTXSID1037197 Css NA 0.009152 mg/L PBTK NA 50% Human Human -DTXSID1037197 Css NA 0.08395 mg/L PBTK NA 95% Human Human +DTXSID1037197 Css NA 0.009129 mg/L 3compartmentss NA 50% Human Human +DTXSID1037197 Css NA 0.1185 mg/L 3compartmentss NA 95% Human Human +DTXSID1037197 Css NA 0.007486 mg/L PBTK NA 50% Human Human +DTXSID1037197 Css NA 0.08392 mg/L PBTK NA 95% Human Human DTXSID1037197 Clint 57.11 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1037197 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1037197 Vd NA 0.7694 L/kg 1compartment NA NA Rat Human DTXSID1037197 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1037197 TK.Half.Life NA 0.2382 hours 1compartment NA NA Rat Human -DTXSID1037197 Css NA 0.005788 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037197 Css NA 0.05606 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037197 Css NA 0.004688 mg/L PBTK NA 50% Rat Human -DTXSID1037197 Css NA 0.03851 mg/L PBTK NA 95% Rat Human -DTXSID1037224 Clint NA 83.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037224 Fup NA 0.284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037224 Vd NA 2.536 L/kg 1compartment NA NA Human Human -DTXSID1037224 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1037224 TK.Half.Life NA 2.819 hours 1compartment NA NA Human Human -DTXSID1037224 Css NA 0.04474 mg/L 3compartmentss NA 50% Human Human -DTXSID1037224 Css NA 0.2914 mg/L 3compartmentss NA 95% Human Human -DTXSID1037224 Css NA 0.03334 mg/L PBTK NA 50% Human Human -DTXSID1037224 Css NA 0.2087 mg/L PBTK NA 95% Human Human -DTXSID1037224 Clint NA 83.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037224 Fup NA 0.284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037224 Vd NA 1.948 L/kg 1compartment NA NA Rat Human -DTXSID1037224 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1037224 TK.Half.Life NA 0.8672 hours 1compartment NA NA Rat Human -DTXSID1037224 Css NA 0.02454 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037224 Css NA 0.1352 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037224 Css NA 0.01766 mg/L PBTK NA 50% Rat Human -DTXSID1037224 Css NA 0.09353 mg/L PBTK NA 95% Rat Human +DTXSID1037197 Css NA 0.001126 mg/L 3compartmentss NA 50% Rat Human +DTXSID1037197 Css NA 0.01216 mg/L 3compartmentss NA 95% Rat Human +DTXSID1037197 Css NA 0.0009511 mg/L PBTK NA 50% Rat Human +DTXSID1037197 Css NA 0.008612 mg/L PBTK NA 95% Rat Human +DTXSID1037224 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037224 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037224 Vd NA 2.284 L/kg 1compartment NA NA Human Human +DTXSID1037224 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID1037224 TK.Half.Life NA 97.79 hours 1compartment NA NA Human Human +DTXSID1037224 Css NA 4.449 mg/L 3compartmentss NA 50% Human Human +DTXSID1037224 Css NA 14.5 mg/L 3compartmentss NA 95% Human Human +DTXSID1037224 Css NA 3.418 mg/L PBTK NA 50% Human Human +DTXSID1037224 Css NA 9.797 mg/L PBTK NA 95% Human Human +DTXSID1037224 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037224 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037224 Vd NA 1.779 L/kg 1compartment NA NA Rat Human +DTXSID1037224 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID1037224 TK.Half.Life NA 15.58 hours 1compartment NA NA Rat Human +DTXSID1037224 Css NA 0.2797 mg/L 3compartmentss NA 50% Rat Human +DTXSID1037224 Css NA 0.7625 mg/L 3compartmentss NA 95% Rat Human +DTXSID1037224 Css NA 0.2146 mg/L PBTK NA 50% Rat Human +DTXSID1037224 Css NA 0.4953 mg/L PBTK NA 95% Rat Human DTXSID1037272 Clint 1000 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID1037272 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID1037272 Vd NA 6.879 L/kg 1compartment NA NA Human Human +DTXSID1037272 Vd NA 5.555 L/kg 1compartment NA NA Human Human DTXSID1037272 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1037272 TK.Half.Life NA 2.297 hours 1compartment NA NA Human Human -DTXSID1037272 Css NA 0.0002905 mg/L 3compartmentss NA 50% Human Human -DTXSID1037272 Css NA 0.005082 mg/L 3compartmentss NA 95% Human Human -DTXSID1037272 Css NA 0.0003784 mg/L PBTK NA 50% Human Human -DTXSID1037272 Css NA 0.005066 mg/L PBTK NA 95% Human Human +DTXSID1037272 TK.Half.Life NA 1.858 hours 1compartment NA NA Human Human +DTXSID1037272 Css NA 5.511e-05 mg/L 3compartmentss NA 50% Human Human +DTXSID1037272 Css NA 0.002274 mg/L 3compartmentss NA 95% Human Human +DTXSID1037272 Css NA 8.768e-05 mg/L PBTK NA 50% Human Human +DTXSID1037272 Css NA 0.003633 mg/L PBTK NA 95% Human Human DTXSID1037272 Clint 1000 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID1037272 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human -DTXSID1037272 Vd NA 3.758 L/kg 1compartment NA NA Rat Human +DTXSID1037272 Vd NA 3.12 L/kg 1compartment NA NA Rat Human DTXSID1037272 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1037272 TK.Half.Life NA 0.5631 hours 1compartment NA NA Rat Human -DTXSID1037272 Css NA 0.0002379 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037272 Css NA 0.002307 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037272 Css NA 0.0003628 mg/L PBTK NA 50% Rat Human -DTXSID1037272 Css NA 0.002385 mg/L PBTK NA 95% Rat Human -DTXSID1037303 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID1037303 Fup 0.00164 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID1037303 Vd NA 0.1644 L/kg 1compartment NA NA Human Human -DTXSID1037303 Days.Css NA 193 Days PBTK NA NA Human Human -DTXSID1037303 TK.Half.Life NA 648.4 hours 1compartment NA NA Human Human -DTXSID1037303 Css NA 686.7 mg/L 3compartmentss NA 50% Human Human -DTXSID1037303 Css NA 3840 mg/L 3compartmentss NA 95% Human Human -DTXSID1037303 Css NA 398 mg/L PBTK NA 50% Human Human -DTXSID1037303 Css NA 2239 mg/L PBTK NA 95% Human Human -DTXSID1037303 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID1037303 Fup 0.00164 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID1037303 Vd NA 0.1624 L/kg 1compartment NA NA Rat Human -DTXSID1037303 Days.Css NA 58 Days PBTK NA NA Rat Human -DTXSID1037303 TK.Half.Life NA 218.3 hours 1compartment NA NA Rat Human -DTXSID1037303 Css NA 194.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037303 Css NA 942.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037303 Css NA 105.1 mg/L PBTK NA 50% Rat Human -DTXSID1037303 Css NA 509 mg/L PBTK NA 95% Rat Human -DTXSID1037511 Clint NA 88.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037511 Fup NA 0.1282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037511 Vd NA 2.18 L/kg 1compartment NA NA Human Human -DTXSID1037511 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1037511 TK.Half.Life NA 2.956 hours 1compartment NA NA Human Human -DTXSID1037511 Css NA 0.08039 mg/L 3compartmentss NA 50% Human Human -DTXSID1037511 Css NA 0.5993 mg/L 3compartmentss NA 95% Human Human -DTXSID1037511 Css NA 0.05542 mg/L PBTK NA 50% Human Human -DTXSID1037511 Css NA 0.393 mg/L PBTK NA 95% Human Human -DTXSID1037511 Clint NA 88.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037511 Fup NA 0.1282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037511 Vd NA 1.655 L/kg 1compartment NA NA Rat Human -DTXSID1037511 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1037511 TK.Half.Life NA 0.9528 hours 1compartment NA NA Rat Human -DTXSID1037511 Css NA 0.0446 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037511 Css NA 0.2642 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037511 Css NA 0.02938 mg/L PBTK NA 50% Rat Human -DTXSID1037511 Css NA 0.1667 mg/L PBTK NA 95% Rat Human -DTXSID1037515 Clint NA 182 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037515 Fup NA 0.0434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037515 Vd NA 1.322 L/kg 1compartment NA NA Human Human +DTXSID1037272 TK.Half.Life NA 0.4693 hours 1compartment NA NA Rat Human +DTXSID1037272 Css NA 2.163e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID1037272 Css NA 0.000311 mg/L 3compartmentss NA 95% Rat Human +DTXSID1037272 Css NA 3.686e-05 mg/L PBTK NA 50% Rat Human +DTXSID1037272 Css NA 0.0005201 mg/L PBTK NA 95% Rat Human +DTXSID1037515 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037515 Fup 0.0595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037515 Vd NA 1.524 L/kg 1compartment NA NA Human Human DTXSID1037515 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1037515 TK.Half.Life NA 1.85 hours 1compartment NA NA Human Human -DTXSID1037515 Css NA 0.08877 mg/L 3compartmentss NA 50% Human Human -DTXSID1037515 Css NA 0.7395 mg/L 3compartmentss NA 95% Human Human -DTXSID1037515 Css NA 0.05616 mg/L PBTK NA 50% Human Human -DTXSID1037515 Css NA 0.4484 mg/L PBTK NA 95% Human Human -DTXSID1037515 Clint NA 182 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037515 Fup NA 0.0434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037515 Vd NA 0.9894 L/kg 1compartment NA NA Rat Human +DTXSID1037515 TK.Half.Life NA 6.365 hours 1compartment NA NA Human Human +DTXSID1037515 Css NA 0.5361 mg/L 3compartmentss NA 50% Human Human +DTXSID1037515 Css NA 4.052 mg/L 3compartmentss NA 95% Human Human +DTXSID1037515 Css NA 0.3452 mg/L PBTK NA 50% Human Human +DTXSID1037515 Css NA 2.467 mg/L PBTK NA 95% Human Human +DTXSID1037515 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037515 Fup 0.0595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037515 Vd NA 1.144 L/kg 1compartment NA NA Rat Human DTXSID1037515 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1037515 TK.Half.Life NA 0.6717 hours 1compartment NA NA Rat Human -DTXSID1037515 Css NA 0.05048 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037515 Css NA 0.3612 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037515 Css NA 0.02994 mg/L PBTK NA 50% Rat Human -DTXSID1037515 Css NA 0.2054 mg/L PBTK NA 95% Rat Human -DTXSID1037565 Clint NA 51.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037565 Fup NA 0.0335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037565 Vd NA 2.108 L/kg 1compartment NA NA Human Human -DTXSID1037565 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1037565 TK.Half.Life NA 7.719 hours 1compartment NA NA Human Human -DTXSID1037565 Css NA 0.4622 mg/L 3compartmentss NA 50% Human Human -DTXSID1037565 Css NA 3.276 mg/L 3compartmentss NA 95% Human Human -DTXSID1037565 Css NA 0.2998 mg/L PBTK NA 50% Human Human -DTXSID1037565 Css NA 2.061 mg/L PBTK NA 95% Human Human -DTXSID1037565 Clint NA 51.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037565 Fup NA 0.0335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037565 Vd NA 1.573 L/kg 1compartment NA NA Rat Human +DTXSID1037515 TK.Half.Life NA 2.417 hours 1compartment NA NA Rat Human +DTXSID1037515 Css NA 0.06924 mg/L 3compartmentss NA 50% Rat Human +DTXSID1037515 Css NA 0.4039 mg/L 3compartmentss NA 95% Rat Human +DTXSID1037515 Css NA 0.0434 mg/L PBTK NA 50% Rat Human +DTXSID1037515 Css NA 0.2444 mg/L PBTK NA 95% Rat Human +DTXSID1037565 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037565 Fup 0.0155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037565 Vd NA 1.598 L/kg 1compartment NA NA Human Human +DTXSID1037565 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1037565 TK.Half.Life NA 17.88 hours 1compartment NA NA Human Human +DTXSID1037565 Css NA 1.741 mg/L 3compartmentss NA 50% Human Human +DTXSID1037565 Css NA 15.23 mg/L 3compartmentss NA 95% Human Human +DTXSID1037565 Css NA 1.09 mg/L PBTK NA 50% Human Human +DTXSID1037565 Css NA 9.221 mg/L PBTK NA 95% Human Human +DTXSID1037565 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037565 Fup 0.0155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037565 Vd NA 1.183 L/kg 1compartment NA NA Rat Human DTXSID1037565 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1037565 TK.Half.Life NA 2.421 hours 1compartment NA NA Rat Human -DTXSID1037565 Css NA 0.2597 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037565 Css NA 1.516 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037565 Css NA 0.1596 mg/L PBTK NA 50% Rat Human -DTXSID1037565 Css NA 0.91 mg/L PBTK NA 95% Rat Human -DTXSID1037567 Clint NA 15.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037567 Fup NA 0.1143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037567 Vd NA 0.2974 L/kg 1compartment NA NA Human Human +DTXSID1037565 TK.Half.Life NA 6.678 hours 1compartment NA NA Rat Human +DTXSID1037565 Css NA 0.2292 mg/L 3compartmentss NA 50% Rat Human +DTXSID1037565 Css NA 1.588 mg/L 3compartmentss NA 95% Rat Human +DTXSID1037565 Css NA 0.1398 mg/L PBTK NA 50% Rat Human +DTXSID1037565 Css NA 0.938 mg/L PBTK NA 95% Rat Human +DTXSID1037567 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037567 Fup 0.157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037567 Vd NA 0.44 L/kg 1compartment NA NA Human Human DTXSID1037567 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1037567 TK.Half.Life NA 0.8939 hours 1compartment NA NA Human Human -DTXSID1037567 Css NA 0.3678 mg/L 3compartmentss NA 50% Human Human -DTXSID1037567 Css NA 2.804 mg/L 3compartmentss NA 95% Human Human -DTXSID1037567 Css NA 0.2305 mg/L PBTK NA 50% Human Human -DTXSID1037567 Css NA 1.681 mg/L PBTK NA 95% Human Human -DTXSID1037567 Clint NA 15.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037567 Fup NA 0.1143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037567 Vd NA 0.2939 L/kg 1compartment NA NA Rat Human +DTXSID1037567 TK.Half.Life NA 1.895 hours 1compartment NA NA Human Human +DTXSID1037567 Css NA 0.2664 mg/L 3compartmentss NA 50% Human Human +DTXSID1037567 Css NA 1.975 mg/L 3compartmentss NA 95% Human Human +DTXSID1037567 Css NA 0.1804 mg/L PBTK NA 50% Human Human +DTXSID1037567 Css NA 1.242 mg/L PBTK NA 95% Human Human +DTXSID1037567 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037567 Fup 0.157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037567 Vd NA 0.4294 L/kg 1compartment NA NA Rat Human DTXSID1037567 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1037567 TK.Half.Life NA 0.5299 hours 1compartment NA NA Rat Human -DTXSID1037567 Css NA 0.2016 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037567 Css NA 1.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037567 Css NA 0.1178 mg/L PBTK NA 50% Rat Human -DTXSID1037567 Css NA 0.6498 mg/L PBTK NA 95% Rat Human -DTXSID1037696 Clint NA 31.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037696 Fup NA 0.5175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037696 Vd NA 5.292 L/kg 1compartment NA NA Human Human +DTXSID1037567 TK.Half.Life NA 1.106 hours 1compartment NA NA Rat Human +DTXSID1037567 Css NA 0.002586 mg/L 3compartmentss NA 50% Rat Human +DTXSID1037567 Css NA 0.01701 mg/L 3compartmentss NA 95% Rat Human +DTXSID1037567 Css NA 0.001672 mg/L PBTK NA 50% Rat Human +DTXSID1037567 Css NA 0.01011 mg/L PBTK NA 95% Rat Human +DTXSID1037696 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037696 Fup 0.358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1037696 Vd NA 4.05 L/kg 1compartment NA NA Human Human DTXSID1037696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1037696 TK.Half.Life NA 2.603 hours 1compartment NA NA Human Human -DTXSID1037696 Css NA 0.0116 mg/L 3compartmentss NA 50% Human Human -DTXSID1037696 Css NA 0.1319 mg/L 3compartmentss NA 95% Human Human -DTXSID1037696 Css NA 0.0188 mg/L PBTK NA 50% Human Human -DTXSID1037696 Css NA 0.1419 mg/L PBTK NA 95% Human Human -DTXSID1037696 Clint NA 31.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037696 Fup NA 0.5175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037696 Vd NA 5.391 L/kg 1compartment NA NA Rat Human +DTXSID1037696 TK.Half.Life NA 3.129 hours 1compartment NA NA Human Human +DTXSID1037696 Css NA 0.02471 mg/L 3compartmentss NA 50% Human Human +DTXSID1037696 Css NA 0.2378 mg/L 3compartmentss NA 95% Human Human +DTXSID1037696 Css NA 0.0332 mg/L PBTK NA 50% Human Human +DTXSID1037696 Css NA 0.2419 mg/L PBTK NA 95% Human Human +DTXSID1037696 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037696 Fup 0.358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1037696 Vd NA 4.103 L/kg 1compartment NA NA Rat Human DTXSID1037696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1037696 TK.Half.Life NA 1.389 hours 1compartment NA NA Rat Human -DTXSID1037696 Css NA 0.005721 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037696 Css NA 0.06297 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037696 Css NA 0.009659 mg/L PBTK NA 50% Rat Human -DTXSID1037696 Css NA 0.06245 mg/L PBTK NA 95% Rat Human +DTXSID1037696 TK.Half.Life NA 1.751 hours 1compartment NA NA Rat Human +DTXSID1037696 Css NA 0.002973 mg/L 3compartmentss NA 50% Rat Human +DTXSID1037696 Css NA 0.0232 mg/L 3compartmentss NA 95% Rat Human +DTXSID1037696 Css NA 0.00422 mg/L PBTK NA 50% Rat Human +DTXSID1037696 Css NA 0.02361 mg/L PBTK NA 95% Rat Human DTXSID1037806 Clint NA 0.1251 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1037806 Fup NA 0.9968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1037806 Vd NA 1.068 L/kg 1compartment NA NA Human Human -DTXSID1037806 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1037806 TK.Half.Life NA 5.859 hours 1compartment NA NA Human Human -DTXSID1037806 Css NA 0.6488 mg/L 3compartmentss NA 50% Human Human -DTXSID1037806 Css NA 2.78 mg/L 3compartmentss NA 95% Human Human -DTXSID1037806 Css NA 0.5798 mg/L PBTK NA 50% Human Human -DTXSID1037806 Css NA 1.966 mg/L PBTK NA 95% Human Human +DTXSID1037806 Vd NA 2.464 L/kg 1compartment NA NA Human Human +DTXSID1037806 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1037806 TK.Half.Life NA 24.8 hours 1compartment NA NA Human Human +DTXSID1037806 Css NA 0.7448 mg/L 3compartmentss NA 50% Human Human +DTXSID1037806 Css NA 3.145 mg/L 3compartmentss NA 95% Human Human +DTXSID1037806 Css NA 0.7256 mg/L PBTK NA 50% Human Human +DTXSID1037806 Css NA 2.404 mg/L PBTK NA 95% Human Human DTXSID1037806 Clint NA 0.1251 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1037806 Fup NA 0.9968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1037806 Vd NA 1.057 L/kg 1compartment NA NA Rat Human +DTXSID1037806 Vd NA 2.027 L/kg 1compartment NA NA Rat Human DTXSID1037806 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1037806 TK.Half.Life NA 2.135 hours 1compartment NA NA Rat Human -DTXSID1037806 Css NA 0.1822 mg/L 3compartmentss NA 50% Rat Human -DTXSID1037806 Css NA 0.7137 mg/L 3compartmentss NA 95% Rat Human -DTXSID1037806 Css NA 0.1607 mg/L PBTK NA 50% Rat Human -DTXSID1037806 Css NA 0.469 mg/L PBTK NA 95% Rat Human +DTXSID1037806 TK.Half.Life NA 4.909 hours 1compartment NA NA Rat Human +DTXSID1037806 Css NA 0.01497 mg/L 3compartmentss NA 50% Rat Human +DTXSID1037806 Css NA 0.08822 mg/L 3compartmentss NA 95% Rat Human +DTXSID1037806 Css NA 0.01418 mg/L PBTK NA 50% Rat Human +DTXSID1037806 Css NA 0.0704 mg/L PBTK NA 95% Rat Human DTXSID1038321 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1038321 Fup 0.00716 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1038321 Vd NA 0.2088 L/kg 1compartment NA NA Human Human DTXSID1038321 Days.Css NA 44 Days PBTK NA NA Human Human DTXSID1038321 TK.Half.Life NA 188.8 hours 1compartment NA NA Human Human -DTXSID1038321 Css NA 89.7 mg/L 3compartmentss NA 50% Human Human -DTXSID1038321 Css NA 398.2 mg/L 3compartmentss NA 95% Human Human -DTXSID1038321 Css NA 53.22 mg/L PBTK NA 50% Human Human -DTXSID1038321 Css NA 233.9 mg/L PBTK NA 95% Human Human +DTXSID1038321 Css NA 86.74 mg/L 3compartmentss NA 50% Human Human +DTXSID1038321 Css NA 385.1 mg/L 3compartmentss NA 95% Human Human +DTXSID1038321 Css NA 51.59 mg/L PBTK NA 50% Human Human +DTXSID1038321 Css NA 222.1 mg/L PBTK NA 95% Human Human DTXSID1038321 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1038321 Fup 0.00716 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1038321 Vd NA 0.1998 L/kg 1compartment NA NA Rat Human DTXSID1038321 Days.Css NA 12 Days PBTK NA NA Rat Human DTXSID1038321 TK.Half.Life NA 61.5 hours 1compartment NA NA Rat Human -DTXSID1038321 Css NA 25.74 mg/L 3compartmentss NA 50% Rat Human -DTXSID1038321 Css NA 92.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID1038321 Css NA 14.24 mg/L PBTK NA 50% Rat Human -DTXSID1038321 Css NA 50.53 mg/L PBTK NA 95% Rat Human +DTXSID1038321 Css NA 5.718 mg/L 3compartmentss NA 50% Rat Human +DTXSID1038321 Css NA 21.35 mg/L 3compartmentss NA 95% Rat Human +DTXSID1038321 Css NA 3.279 mg/L PBTK NA 50% Rat Human +DTXSID1038321 Css NA 12.02 mg/L PBTK NA 95% Rat Human DTXSID1038666 Clint 43.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1038666 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1038666 Vd NA 1.303 L/kg 1compartment NA NA Human Human +DTXSID1038666 Fup 0.0828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038666 Vd NA 2.067 L/kg 1compartment NA NA Human Human DTXSID1038666 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1038666 TK.Half.Life NA 5.352 hours 1compartment NA NA Human Human -DTXSID1038666 Css NA 0.5732 mg/L 3compartmentss NA 50% Human Human -DTXSID1038666 Css NA 5.17 mg/L 3compartmentss NA 95% Human Human -DTXSID1038666 Css NA 0.3572 mg/L PBTK NA 50% Human Human -DTXSID1038666 Css NA 3.089 mg/L PBTK NA 95% Human Human +DTXSID1038666 TK.Half.Life NA 4.926 hours 1compartment NA NA Human Human +DTXSID1038666 Css NA 0.2266 mg/L 3compartmentss NA 50% Human Human +DTXSID1038666 Css NA 1.61 mg/L 3compartmentss NA 95% Human Human +DTXSID1038666 Css NA 0.1516 mg/L PBTK NA 50% Human Human +DTXSID1038666 Css NA 1.028 mg/L PBTK NA 95% Human Human DTXSID1038666 Clint 43.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1038666 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1038666 Vd NA 0.971 L/kg 1compartment NA NA Rat Human +DTXSID1038666 Fup 0.0828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038666 Vd NA 1.559 L/kg 1compartment NA NA Rat Human DTXSID1038666 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1038666 TK.Half.Life NA 2.151 hours 1compartment NA NA Rat Human -DTXSID1038666 Css NA 0.3241 mg/L 3compartmentss NA 50% Rat Human -DTXSID1038666 Css NA 2.326 mg/L 3compartmentss NA 95% Rat Human -DTXSID1038666 Css NA 0.1889 mg/L PBTK NA 50% Rat Human -DTXSID1038666 Css NA 1.301 mg/L PBTK NA 95% Rat Human -DTXSID1038743 Clint NA 0.8334 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1038743 Fup NA 0.339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1038743 Vd NA 0.7255 L/kg 1compartment NA NA Human Human +DTXSID1038666 TK.Half.Life NA 1.6 hours 1compartment NA NA Rat Human +DTXSID1038666 Css NA 0.02926 mg/L 3compartmentss NA 50% Rat Human +DTXSID1038666 Css NA 0.1736 mg/L 3compartmentss NA 95% Rat Human +DTXSID1038666 Css NA 0.01919 mg/L PBTK NA 50% Rat Human +DTXSID1038666 Css NA 0.1086 mg/L PBTK NA 95% Rat Human +DTXSID1038743 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038743 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038743 Vd NA 0.7881 L/kg 1compartment NA NA Human Human DTXSID1038743 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1038743 TK.Half.Life NA 6.091 hours 1compartment NA NA Human Human -DTXSID1038743 Css NA 0.91 mg/L 3compartmentss NA 50% Human Human -DTXSID1038743 Css NA 4.135 mg/L 3compartmentss NA 95% Human Human -DTXSID1038743 Css NA 0.6736 mg/L PBTK NA 50% Human Human -DTXSID1038743 Css NA 2.653 mg/L PBTK NA 95% Human Human -DTXSID1038743 Clint NA 0.8334 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1038743 Fup NA 0.339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1038743 Vd NA 0.6725 L/kg 1compartment NA NA Rat Human +DTXSID1038743 TK.Half.Life NA 1.595 hours 1compartment NA NA Human Human +DTXSID1038743 Css NA 0.1594 mg/L 3compartmentss NA 50% Human Human +DTXSID1038743 Css NA 1.069 mg/L 3compartmentss NA 95% Human Human +DTXSID1038743 Css NA 0.1216 mg/L PBTK NA 50% Human Human +DTXSID1038743 Css NA 0.715 mg/L PBTK NA 95% Human Human +DTXSID1038743 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038743 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038743 Vd NA 0.7336 L/kg 1compartment NA NA Rat Human DTXSID1038743 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1038743 TK.Half.Life NA 2.653 hours 1compartment NA NA Rat Human -DTXSID1038743 Css NA 0.3543 mg/L 3compartmentss NA 50% Rat Human -DTXSID1038743 Css NA 1.353 mg/L 3compartmentss NA 95% Rat Human -DTXSID1038743 Css NA 0.25 mg/L PBTK NA 50% Rat Human -DTXSID1038743 Css NA 0.8107 mg/L PBTK NA 95% Rat Human -DTXSID1038822 Clint NA 84.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1038743 TK.Half.Life NA 0.82 hours 1compartment NA NA Rat Human +DTXSID1038743 Css NA 0.01841 mg/L 3compartmentss NA 50% Rat Human +DTXSID1038743 Css NA 0.09394 mg/L 3compartmentss NA 95% Rat Human +DTXSID1038743 Css NA 0.01398 mg/L PBTK NA 50% Rat Human +DTXSID1038743 Css NA 0.06126 mg/L PBTK NA 95% Rat Human +DTXSID1038799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038799 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038799 Vd NA 2.501 L/kg 1compartment NA NA Human Human +DTXSID1038799 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1038799 TK.Half.Life NA 2.664 hours 1compartment NA NA Human Human +DTXSID1038799 Css NA 0.04618 mg/L 3compartmentss NA 50% Human Human +DTXSID1038799 Css NA 0.3832 mg/L 3compartmentss NA 95% Human Human +DTXSID1038799 Css NA 0.0443 mg/L PBTK NA 50% Human Human +DTXSID1038799 Css NA 0.3122 mg/L PBTK NA 95% Human Human +DTXSID1038799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038799 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038799 Vd NA 2.414 L/kg 1compartment NA NA Rat Human +DTXSID1038799 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1038799 TK.Half.Life NA 1.335 hours 1compartment NA NA Rat Human +DTXSID1038799 Css NA 0.005706 mg/L 3compartmentss NA 50% Rat Human +DTXSID1038799 Css NA 0.03632 mg/L 3compartmentss NA 95% Rat Human +DTXSID1038799 Css NA 0.005583 mg/L PBTK NA 50% Rat Human +DTXSID1038799 Css NA 0.0291 mg/L PBTK NA 95% Rat Human +DTXSID1038822 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1038822 Fup 0.7388 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID1038822 Vd NA 3.135 L/kg 1compartment NA NA Human Human -DTXSID1038822 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1038822 TK.Half.Life NA 7.307 hours 1compartment NA NA Human Human -DTXSID1038822 Css NA 0.1863 mg/L 3compartmentss NA 50% Human Human -DTXSID1038822 Css NA 1.183 mg/L 3compartmentss NA 95% Human Human -DTXSID1038822 Css NA 0.1334 mg/L PBTK NA 50% Human Human -DTXSID1038822 Css NA 0.8078 mg/L PBTK NA 95% Human Human -DTXSID1038822 Clint NA 84.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1038822 Vd NA 3.14 L/kg 1compartment NA NA Human Human +DTXSID1038822 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID1038822 TK.Half.Life NA 47.84 hours 1compartment NA NA Human Human +DTXSID1038822 Css NA 1.734 mg/L 3compartmentss NA 50% Human Human +DTXSID1038822 Css NA 11.33 mg/L 3compartmentss NA 95% Human Human +DTXSID1038822 Css NA 1.213 mg/L PBTK NA 50% Human Human +DTXSID1038822 Css NA 7.689 mg/L PBTK NA 95% Human Human +DTXSID1038822 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1038822 Fup 0.7388 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID1038822 Vd NA 2.364 L/kg 1compartment NA NA Rat Human -DTXSID1038822 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1038822 TK.Half.Life NA 1.45 hours 1compartment NA NA Rat Human -DTXSID1038822 Css NA 0.1035 mg/L 3compartmentss NA 50% Rat Human -DTXSID1038822 Css NA 0.5554 mg/L 3compartmentss NA 95% Rat Human -DTXSID1038822 Css NA 0.07144 mg/L PBTK NA 50% Rat Human -DTXSID1038822 Css NA 0.3746 mg/L PBTK NA 95% Rat Human -DTXSID1038824 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1038824 Fup NA 0.9676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1038824 Vd NA 0.4746 L/kg 1compartment NA NA Human Human +DTXSID1038822 Vd NA 2.358 L/kg 1compartment NA NA Rat Human +DTXSID1038822 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1038822 TK.Half.Life NA 6.545 hours 1compartment NA NA Rat Human +DTXSID1038822 Css NA 0.2206 mg/L 3compartmentss NA 50% Rat Human +DTXSID1038822 Css NA 1.232 mg/L 3compartmentss NA 95% Rat Human +DTXSID1038822 Css NA 0.1536 mg/L PBTK NA 50% Rat Human +DTXSID1038822 Css NA 0.8385 mg/L PBTK NA 95% Rat Human +DTXSID1038824 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038824 Fup 0.879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038824 Vd NA 0.4891 L/kg 1compartment NA NA Human Human DTXSID1038824 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1038824 TK.Half.Life NA 3.172 hours 1compartment NA NA Human Human -DTXSID1038824 Css NA 0.9998 mg/L 3compartmentss NA 50% Human Human -DTXSID1038824 Css NA 5.296 mg/L 3compartmentss NA 95% Human Human -DTXSID1038824 Css NA 0.7397 mg/L PBTK NA 50% Human Human -DTXSID1038824 Css NA 3.326 mg/L PBTK NA 95% Human Human -DTXSID1038824 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1038824 Fup NA 0.9676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1038824 Vd NA 0.5022 L/kg 1compartment NA NA Rat Human +DTXSID1038824 TK.Half.Life NA 3.601 hours 1compartment NA NA Human Human +DTXSID1038824 Css NA 0.8814 mg/L 3compartmentss NA 50% Human Human +DTXSID1038824 Css NA 4.805 mg/L 3compartmentss NA 95% Human Human +DTXSID1038824 Css NA 0.6573 mg/L PBTK NA 50% Human Human +DTXSID1038824 Css NA 3.062 mg/L PBTK NA 95% Human Human +DTXSID1038824 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038824 Fup 0.879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038824 Vd NA 0.5098 L/kg 1compartment NA NA Rat Human DTXSID1038824 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1038824 TK.Half.Life NA 1.144 hours 1compartment NA NA Rat Human -DTXSID1038824 Css NA 0.2569 mg/L 3compartmentss NA 50% Rat Human -DTXSID1038824 Css NA 1.316 mg/L 3compartmentss NA 95% Rat Human -DTXSID1038824 Css NA 0.1828 mg/L PBTK NA 50% Rat Human -DTXSID1038824 Css NA 0.7648 mg/L PBTK NA 95% Rat Human -DTXSID1038876 Clint NA 250.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1038876 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1038876 Vd NA 1.829 L/kg 1compartment NA NA Human Human -DTXSID1038876 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1038876 TK.Half.Life NA 4.321 hours 1compartment NA NA Human Human -DTXSID1038876 Css NA 0.2494 mg/L 3compartmentss NA 50% Human Human -DTXSID1038876 Css NA 2.203 mg/L 3compartmentss NA 95% Human Human -DTXSID1038876 Css NA 0.1572 mg/L PBTK NA 50% Human Human -DTXSID1038876 Css NA 1.32 mg/L PBTK NA 95% Human Human -DTXSID1038876 Clint NA 250.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1038876 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1038876 Vd NA 1.351 L/kg 1compartment NA NA Rat Human -DTXSID1038876 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1038876 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human -DTXSID1038876 Css NA 0.1429 mg/L 3compartmentss NA 50% Rat Human -DTXSID1038876 Css NA 1.055 mg/L 3compartmentss NA 95% Rat Human -DTXSID1038876 Css NA 0.08472 mg/L PBTK NA 50% Rat Human -DTXSID1038876 Css NA 0.5996 mg/L PBTK NA 95% Rat Human -DTXSID1039719 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1039719 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1039719 Vd NA 2.278 L/kg 1compartment NA NA Human Human -DTXSID1039719 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID1039719 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human -DTXSID1039719 Css NA 5.766 mg/L 3compartmentss NA 50% Human Human -DTXSID1039719 Css NA 18.35 mg/L 3compartmentss NA 95% Human Human -DTXSID1039719 Css NA 4.315 mg/L PBTK NA 50% Human Human -DTXSID1039719 Css NA 12.3 mg/L PBTK NA 95% Human Human -DTXSID1039719 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1039719 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1039719 Vd NA 1.758 L/kg 1compartment NA NA Rat Human -DTXSID1039719 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID1039719 TK.Half.Life NA 18.69 hours 1compartment NA NA Rat Human -DTXSID1039719 Css NA 1.568 mg/L 3compartmentss NA 50% Rat Human -DTXSID1039719 Css NA 4.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID1039719 Css NA 1.13 mg/L PBTK NA 50% Rat Human -DTXSID1039719 Css NA 2.563 mg/L PBTK NA 95% Rat Human -DTXSID1040114 Clint NA 1.832 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040114 Fup NA 0.7445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040114 Vd NA 1.199 L/kg 1compartment NA NA Human Human -DTXSID1040114 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040114 TK.Half.Life NA 3.104 hours 1compartment NA NA Human Human -DTXSID1040114 Css NA 0.2523 mg/L 3compartmentss NA 50% Human Human -DTXSID1040114 Css NA 1.829 mg/L 3compartmentss NA 95% Human Human -DTXSID1040114 Css NA 0.2224 mg/L PBTK NA 50% Human Human -DTXSID1040114 Css NA 1.239 mg/L PBTK NA 95% Human Human -DTXSID1040114 Clint NA 1.832 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040114 Fup NA 0.7445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040114 Vd NA 1.111 L/kg 1compartment NA NA Rat Human +DTXSID1038824 TK.Half.Life NA 1.279 hours 1compartment NA NA Rat Human +DTXSID1038824 Css NA 0.01621 mg/L 3compartmentss NA 50% Rat Human +DTXSID1038824 Css NA 0.1144 mg/L 3compartmentss NA 95% Rat Human +DTXSID1038824 Css NA 0.0116 mg/L PBTK NA 50% Rat Human +DTXSID1038824 Css NA 0.07034 mg/L PBTK NA 95% Rat Human +DTXSID1038876 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038876 Fup 0.00862 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038876 Vd NA 1.574 L/kg 1compartment NA NA Human Human +DTXSID1038876 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1038876 TK.Half.Life NA 26.07 hours 1compartment NA NA Human Human +DTXSID1038876 Css NA 2.706 mg/L 3compartmentss NA 50% Human Human +DTXSID1038876 Css NA 24.37 mg/L 3compartmentss NA 95% Human Human +DTXSID1038876 Css NA 1.682 mg/L PBTK NA 50% Human Human +DTXSID1038876 Css NA 14.77 mg/L PBTK NA 95% Human Human +DTXSID1038876 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038876 Fup 0.00862 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038876 Vd NA 1.161 L/kg 1compartment NA NA Rat Human +DTXSID1038876 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1038876 TK.Half.Life NA 9.803 hours 1compartment NA NA Rat Human +DTXSID1038876 Css NA 0.3527 mg/L 3compartmentss NA 50% Rat Human +DTXSID1038876 Css NA 2.575 mg/L 3compartmentss NA 95% Rat Human +DTXSID1038876 Css NA 0.213 mg/L PBTK NA 50% Rat Human +DTXSID1038876 Css NA 1.493 mg/L PBTK NA 95% Rat Human +DTXSID1038878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038878 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1038878 Vd NA 1.136 L/kg 1compartment NA NA Human Human +DTXSID1038878 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1038878 TK.Half.Life NA 10.52 hours 1compartment NA NA Human Human +DTXSID1038878 Css NA 1.497 mg/L 3compartmentss NA 50% Human Human +DTXSID1038878 Css NA 13.47 mg/L 3compartmentss NA 95% Human Human +DTXSID1038878 Css NA 0.9176 mg/L PBTK NA 50% Human Human +DTXSID1038878 Css NA 7.998 mg/L PBTK NA 95% Human Human +DTXSID1038878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038878 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1038878 Vd NA 0.8427 L/kg 1compartment NA NA Rat Human +DTXSID1038878 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1038878 TK.Half.Life NA 4.458 hours 1compartment NA NA Rat Human +DTXSID1038878 Css NA 0.1916 mg/L 3compartmentss NA 50% Rat Human +DTXSID1038878 Css NA 1.497 mg/L 3compartmentss NA 95% Rat Human +DTXSID1038878 Css NA 0.114 mg/L PBTK NA 50% Rat Human +DTXSID1038878 Css NA 0.8569 mg/L PBTK NA 95% Rat Human +DTXSID10393157 Clint 4.974 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10393157 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10393157 Vd NA 1.65 L/kg 1compartment NA NA Human Human +DTXSID10393157 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10393157 TK.Half.Life NA 11.76 hours 1compartment NA NA Human Human +DTXSID10393157 Css NA 0.8956 mg/L 3compartmentss NA 50% Human Human +DTXSID10393157 Css NA 5.521 mg/L 3compartmentss NA 95% Human Human +DTXSID10393157 Css NA 0.6112 mg/L PBTK NA 50% Human Human +DTXSID10393157 Css NA 3.503 mg/L PBTK NA 95% Human Human +DTXSID10393157 Clint 4.974 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10393157 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10393157 Vd NA 1.267 L/kg 1compartment NA NA Rat Human +DTXSID10393157 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10393157 TK.Half.Life NA 4.255 hours 1compartment NA NA Rat Human +DTXSID10393157 Css NA 0.107 mg/L 3compartmentss NA 50% Rat Human +DTXSID10393157 Css NA 0.4975 mg/L 3compartmentss NA 95% Rat Human +DTXSID10393157 Css NA 0.07182 mg/L PBTK NA 50% Rat Human +DTXSID10393157 Css NA 0.303 mg/L PBTK NA 95% Rat Human +DTXSID1040114 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040114 Fup 0.611 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040114 Vd NA 1.334 L/kg 1compartment NA NA Human Human +DTXSID1040114 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1040114 TK.Half.Life NA 15.9 hours 1compartment NA NA Human Human +DTXSID1040114 Css NA 1.184 mg/L 3compartmentss NA 50% Human Human +DTXSID1040114 Css NA 8.222 mg/L 3compartmentss NA 95% Human Human +DTXSID1040114 Css NA 1.03 mg/L PBTK NA 50% Human Human +DTXSID1040114 Css NA 5.406 mg/L PBTK NA 95% Human Human +DTXSID1040114 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040114 Fup 0.611 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040114 Vd NA 1.178 L/kg 1compartment NA NA Rat Human DTXSID1040114 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040114 TK.Half.Life NA 1.436 hours 1compartment NA NA Rat Human -DTXSID1040114 Css NA 0.106 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040114 Css NA 0.7403 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040114 Css NA 0.09136 mg/L PBTK NA 50% Rat Human -DTXSID1040114 Css NA 0.4565 mg/L PBTK NA 95% Rat Human +DTXSID1040114 TK.Half.Life NA 4.379 hours 1compartment NA NA Rat Human +DTXSID1040114 Css NA 0.07282 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040114 Css NA 0.4671 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040114 Css NA 0.06334 mg/L PBTK NA 50% Rat Human +DTXSID1040114 Css NA 0.2926 mg/L PBTK NA 95% Rat Human DTXSID1040164 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1040164 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040164 Vd NA 0.8239 L/kg 1compartment NA NA Human Human +DTXSID1040164 Vd NA 0.7522 L/kg 1compartment NA NA Human Human DTXSID1040164 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040164 TK.Half.Life NA 5.336 hours 1compartment NA NA Human Human -DTXSID1040164 Css NA 0.8137 mg/L 3compartmentss NA 50% Human Human -DTXSID1040164 Css NA 5.619 mg/L 3compartmentss NA 95% Human Human -DTXSID1040164 Css NA 0.6937 mg/L PBTK NA 50% Human Human -DTXSID1040164 Css NA 3.755 mg/L PBTK NA 95% Human Human +DTXSID1040164 TK.Half.Life NA 4.868 hours 1compartment NA NA Human Human +DTXSID1040164 Css NA 0.7033 mg/L 3compartmentss NA 50% Human Human +DTXSID1040164 Css NA 5.051 mg/L 3compartmentss NA 95% Human Human +DTXSID1040164 Css NA 0.5894 mg/L PBTK NA 50% Human Human +DTXSID1040164 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID1040164 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1040164 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040164 Vd NA 0.855 L/kg 1compartment NA NA Rat Human +DTXSID1040164 Vd NA 0.7934 L/kg 1compartment NA NA Rat Human DTXSID1040164 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040164 TK.Half.Life NA 1.886 hours 1compartment NA NA Rat Human -DTXSID1040164 Css NA 0.2048 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040164 Css NA 1.305 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040164 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID1040164 Css NA 0.7895 mg/L PBTK NA 95% Rat Human -DTXSID1040245 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040245 Fup NA 0.3525 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040245 Vd NA 0.4552 L/kg 1compartment NA NA Human Human +DTXSID1040164 TK.Half.Life NA 1.75 hours 1compartment NA NA Rat Human +DTXSID1040164 Css NA 0.01291 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040164 Css NA 0.1001 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040164 Css NA 0.0105 mg/L PBTK NA 50% Rat Human +DTXSID1040164 Css NA 0.0655 mg/L PBTK NA 95% Rat Human +DTXSID1040243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040243 Fup 0.042 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040243 Vd NA 2.732 L/kg 1compartment NA NA Human Human +DTXSID1040243 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1040243 TK.Half.Life NA 9.998 hours 1compartment NA NA Human Human +DTXSID1040243 Css NA 0.4041 mg/L 3compartmentss NA 50% Human Human +DTXSID1040243 Css NA 2.983 mg/L 3compartmentss NA 95% Human Human +DTXSID1040243 Css NA 0.293 mg/L PBTK NA 50% Human Human +DTXSID1040243 Css NA 2.072 mg/L PBTK NA 95% Human Human +DTXSID1040243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040243 Fup 0.042 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040243 Vd NA 2.238 L/kg 1compartment NA NA Rat Human +DTXSID1040243 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1040243 TK.Half.Life NA 3.349 hours 1compartment NA NA Rat Human +DTXSID1040243 Css NA 0.05234 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040243 Css NA 0.3283 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040243 Css NA 0.03771 mg/L PBTK NA 50% Rat Human +DTXSID1040243 Css NA 0.22 mg/L PBTK NA 95% Rat Human +DTXSID1040245 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040245 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040245 Vd NA 0.6697 L/kg 1compartment NA NA Human Human DTXSID1040245 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040245 TK.Half.Life NA 8.358 hours 1compartment NA NA Human Human -DTXSID1040245 Css NA 2.144 mg/L 3compartmentss NA 50% Human Human -DTXSID1040245 Css NA 8.647 mg/L 3compartmentss NA 95% Human Human -DTXSID1040245 Css NA 1.508 mg/L PBTK NA 50% Human Human -DTXSID1040245 Css NA 5.396 mg/L PBTK NA 95% Human Human -DTXSID1040245 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040245 Fup NA 0.3525 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040245 Vd NA 0.469 L/kg 1compartment NA NA Rat Human +DTXSID1040245 TK.Half.Life NA 6.43 hours 1compartment NA NA Human Human +DTXSID1040245 Css NA 0.6169 mg/L 3compartmentss NA 50% Human Human +DTXSID1040245 Css NA 4.102 mg/L 3compartmentss NA 95% Human Human +DTXSID1040245 Css NA 0.495 mg/L PBTK NA 50% Human Human +DTXSID1040245 Css NA 2.635 mg/L PBTK NA 95% Human Human +DTXSID1040245 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040245 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040245 Vd NA 0.6904 L/kg 1compartment NA NA Rat Human DTXSID1040245 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040245 TK.Half.Life NA 2.935 hours 1compartment NA NA Rat Human -DTXSID1040245 Css NA 0.5887 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040245 Css NA 2.041 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040245 Css NA 0.3948 mg/L PBTK NA 50% Rat Human -DTXSID1040245 Css NA 1.191 mg/L PBTK NA 95% Rat Human -DTXSID1040295 Clint NA 20.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040295 Fup NA 0.6455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040295 Vd NA 2.987 L/kg 1compartment NA NA Human Human -DTXSID1040295 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040295 TK.Half.Life NA 2.058 hours 1compartment NA NA Human Human -DTXSID1040295 Css NA 0.02527 mg/L 3compartmentss NA 50% Human Human -DTXSID1040295 Css NA 0.316 mg/L 3compartmentss NA 95% Human Human -DTXSID1040295 Css NA 0.02854 mg/L PBTK NA 50% Human Human -DTXSID1040295 Css NA 0.2568 mg/L PBTK NA 95% Human Human -DTXSID1040295 Clint NA 20.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040295 Fup NA 0.6455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040295 Vd NA 3.033 L/kg 1compartment NA NA Rat Human -DTXSID1040295 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040295 TK.Half.Life NA 1.089 hours 1compartment NA NA Rat Human -DTXSID1040295 Css NA 0.01229 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040295 Css NA 0.1369 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040295 Css NA 0.01439 mg/L PBTK NA 50% Rat Human -DTXSID1040295 Css NA 0.1055 mg/L PBTK NA 95% Rat Human -DTXSID1040320 Clint NA 196.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040320 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040320 Vd NA 2.055 L/kg 1compartment NA NA Human Human -DTXSID1040320 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040320 TK.Half.Life NA 4.037 hours 1compartment NA NA Human Human -DTXSID1040320 Css NA 0.1805 mg/L 3compartmentss NA 50% Human Human -DTXSID1040320 Css NA 1.497 mg/L 3compartmentss NA 95% Human Human -DTXSID1040320 Css NA 0.1158 mg/L PBTK NA 50% Human Human -DTXSID1040320 Css NA 0.9177 mg/L PBTK NA 95% Human Human -DTXSID1040320 Clint NA 196.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040320 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040320 Vd NA 1.526 L/kg 1compartment NA NA Rat Human -DTXSID1040320 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040320 TK.Half.Life NA 1.291 hours 1compartment NA NA Rat Human -DTXSID1040320 Css NA 0.1014 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040320 Css NA 0.7234 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040320 Css NA 0.06178 mg/L PBTK NA 50% Rat Human -DTXSID1040320 Css NA 0.4177 mg/L PBTK NA 95% Rat Human -DTXSID1040324 Clint NA 105.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040324 Fup NA 0.1389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040324 Vd NA 0.9891 L/kg 1compartment NA NA Human Human +DTXSID1040245 TK.Half.Life NA 2.256 hours 1compartment NA NA Rat Human +DTXSID1040245 Css NA 0.003207 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040245 Css NA 0.02325 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040245 Css NA 0.002494 mg/L PBTK NA 50% Rat Human +DTXSID1040245 Css NA 0.01408 mg/L PBTK NA 95% Rat Human +DTXSID1040295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040295 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040295 Vd NA 2.925 L/kg 1compartment NA NA Human Human +DTXSID1040295 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1040295 TK.Half.Life NA 30.23 hours 1compartment NA NA Human Human +DTXSID1040295 Css NA 0.8002 mg/L 3compartmentss NA 50% Human Human +DTXSID1040295 Css NA 6.798 mg/L 3compartmentss NA 95% Human Human +DTXSID1040295 Css NA 0.9288 mg/L PBTK NA 50% Human Human +DTXSID1040295 Css NA 4.926 mg/L PBTK NA 95% Human Human +DTXSID1040295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040295 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040295 Vd NA 2.969 L/kg 1compartment NA NA Rat Human +DTXSID1040295 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1040295 TK.Half.Life NA 10.45 hours 1compartment NA NA Rat Human +DTXSID1040295 Css NA 0.0473 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040295 Css NA 0.3934 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040295 Css NA 0.05627 mg/L PBTK NA 50% Rat Human +DTXSID1040295 Css NA 0.2717 mg/L PBTK NA 95% Rat Human +DTXSID1040320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040320 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040320 Vd NA 1.836 L/kg 1compartment NA NA Human Human +DTXSID1040320 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1040320 TK.Half.Life NA 23.01 hours 1compartment NA NA Human Human +DTXSID1040320 Css NA 1.927 mg/L 3compartmentss NA 50% Human Human +DTXSID1040320 Css NA 16.56 mg/L 3compartmentss NA 95% Human Human +DTXSID1040320 Css NA 1.218 mg/L PBTK NA 50% Human Human +DTXSID1040320 Css NA 10.18 mg/L PBTK NA 95% Human Human +DTXSID1040320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040320 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040320 Vd NA 1.359 L/kg 1compartment NA NA Rat Human +DTXSID1040320 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1040320 TK.Half.Life NA 7.863 hours 1compartment NA NA Rat Human +DTXSID1040320 Css NA 0.25 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040320 Css NA 1.781 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040320 Css NA 0.154 mg/L PBTK NA 50% Rat Human +DTXSID1040320 Css NA 1.064 mg/L PBTK NA 95% Rat Human +DTXSID1040324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040324 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040324 Vd NA 1.098 L/kg 1compartment NA NA Human Human DTXSID1040324 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040324 TK.Half.Life NA 1.097 hours 1compartment NA NA Human Human -DTXSID1040324 Css NA 0.04244 mg/L 3compartmentss NA 50% Human Human -DTXSID1040324 Css NA 0.3639 mg/L 3compartmentss NA 95% Human Human -DTXSID1040324 Css NA 0.0279 mg/L PBTK NA 50% Human Human -DTXSID1040324 Css NA 0.2231 mg/L PBTK NA 95% Human Human -DTXSID1040324 Clint NA 105.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040324 Fup NA 0.1389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040324 Vd NA 0.7808 L/kg 1compartment NA NA Rat Human +DTXSID1040324 TK.Half.Life NA 2.071 hours 1compartment NA NA Human Human +DTXSID1040324 Css NA 0.1387 mg/L 3compartmentss NA 50% Human Human +DTXSID1040324 Css NA 0.9585 mg/L 3compartmentss NA 95% Human Human +DTXSID1040324 Css NA 0.09475 mg/L PBTK NA 50% Human Human +DTXSID1040324 Css NA 0.6275 mg/L PBTK NA 95% Human Human +DTXSID1040324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040324 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040324 Vd NA 0.8681 L/kg 1compartment NA NA Rat Human DTXSID1040324 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040324 TK.Half.Life NA 0.4173 hours 1compartment NA NA Rat Human -DTXSID1040324 Css NA 0.02445 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040324 Css NA 0.1604 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040324 Css NA 0.01522 mg/L PBTK NA 50% Rat Human -DTXSID1040324 Css NA 0.09636 mg/L PBTK NA 95% Rat Human +DTXSID1040324 TK.Half.Life NA 0.8644 hours 1compartment NA NA Rat Human +DTXSID1040324 Css NA 0.01784 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040324 Css NA 0.09431 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040324 Css NA 0.01203 mg/L PBTK NA 50% Rat Human +DTXSID1040324 Css NA 0.06025 mg/L PBTK NA 95% Rat Human DTXSID1040326 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1040326 Fup NA 0.8331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040326 Vd NA 0.6486 L/kg 1compartment NA NA Human Human -DTXSID1040326 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040326 TK.Half.Life NA 5.037 hours 1compartment NA NA Human Human -DTXSID1040326 Css NA 0.9944 mg/L 3compartmentss NA 50% Human Human -DTXSID1040326 Css NA 5.842 mg/L 3compartmentss NA 95% Human Human -DTXSID1040326 Css NA 0.7968 mg/L PBTK NA 50% Human Human -DTXSID1040326 Css NA 3.742 mg/L PBTK NA 95% Human Human +DTXSID1040326 Vd NA 2.225 L/kg 1compartment NA NA Human Human +DTXSID1040326 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1040326 TK.Half.Life NA 28.12 hours 1compartment NA NA Human Human +DTXSID1040326 Css NA 1.176 mg/L 3compartmentss NA 50% Human Human +DTXSID1040326 Css NA 6.729 mg/L 3compartmentss NA 95% Human Human +DTXSID1040326 Css NA 1.102 mg/L PBTK NA 50% Human Human +DTXSID1040326 Css NA 4.612 mg/L PBTK NA 95% Human Human DTXSID1040326 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1040326 Fup NA 0.8331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040326 Vd NA 0.69 L/kg 1compartment NA NA Rat Human +DTXSID1040326 Vd NA 1.844 L/kg 1compartment NA NA Rat Human DTXSID1040326 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040326 TK.Half.Life NA 1.826 hours 1compartment NA NA Rat Human -DTXSID1040326 Css NA 0.2546 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040326 Css NA 1.461 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040326 Css NA 0.1983 mg/L PBTK NA 50% Rat Human -DTXSID1040326 Css NA 0.8685 mg/L PBTK NA 95% Rat Human +DTXSID1040326 TK.Half.Life NA 5.613 hours 1compartment NA NA Rat Human +DTXSID1040326 Css NA 0.07118 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040326 Css NA 0.3547 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040326 Css NA 0.06722 mg/L PBTK NA 50% Rat Human +DTXSID1040326 Css NA 0.237 mg/L PBTK NA 95% Rat Human DTXSID1040372 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1040372 Fup 0.0575 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1040372 Vd NA 1.618 L/kg 1compartment NA NA Human Human -DTXSID1040372 Days.Css NA 62 Days PBTK NA NA Human Human -DTXSID1040372 TK.Half.Life NA 272.1 hours 1compartment NA NA Human Human -DTXSID1040372 Css NA 19.8 mg/L 3compartmentss NA 50% Human Human -DTXSID1040372 Css NA 70.14 mg/L 3compartmentss NA 95% Human Human -DTXSID1040372 Css NA 13.14 mg/L PBTK NA 50% Human Human -DTXSID1040372 Css NA 42.63 mg/L PBTK NA 95% Human Human +DTXSID1040372 Vd NA 2.148 L/kg 1compartment NA NA Human Human +DTXSID1040372 Days.Css NA 126 Days PBTK NA NA Human Human +DTXSID1040372 TK.Half.Life NA 521.2 hours 1compartment NA NA Human Human +DTXSID1040372 Css NA 27.32 mg/L 3compartmentss NA 50% Human Human +DTXSID1040372 Css NA 87.6 mg/L 3compartmentss NA 95% Human Human +DTXSID1040372 Css NA 18.53 mg/L PBTK NA 50% Human Human +DTXSID1040372 Css NA 54.48 mg/L PBTK NA 95% Human Human DTXSID1040372 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1040372 Fup 0.0575 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1040372 Vd NA 1.218 L/kg 1compartment NA NA Rat Human -DTXSID1040372 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID1040372 TK.Half.Life NA 52.19 hours 1compartment NA NA Rat Human -DTXSID1040372 Css NA 5.442 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040372 Css NA 15.97 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040372 Css NA 3.408 mg/L PBTK NA 50% Rat Human -DTXSID1040372 Css NA 9.14 mg/L PBTK NA 95% Rat Human -DTXSID1040459 Clint NA 3.265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040459 Fup NA 0.1669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040459 Vd NA 0.3261 L/kg 1compartment NA NA Human Human +DTXSID1040372 Vd NA 1.611 L/kg 1compartment NA NA Rat Human +DTXSID1040372 Days.Css NA 30 Days PBTK NA NA Rat Human +DTXSID1040372 TK.Half.Life NA 78.8 hours 1compartment NA NA Rat Human +DTXSID1040372 Css NA 1.754 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040372 Css NA 4.585 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040372 Css NA 1.169 mg/L PBTK NA 50% Rat Human +DTXSID1040372 Css NA 2.772 mg/L PBTK NA 95% Rat Human +DTXSID1040459 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040459 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040459 Vd NA 0.709 L/kg 1compartment NA NA Human Human DTXSID1040459 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040459 TK.Half.Life NA 2.178 hours 1compartment NA NA Human Human -DTXSID1040459 Css NA 0.8646 mg/L 3compartmentss NA 50% Human Human -DTXSID1040459 Css NA 4.593 mg/L 3compartmentss NA 95% Human Human -DTXSID1040459 Css NA 0.548 mg/L PBTK NA 50% Human Human -DTXSID1040459 Css NA 2.779 mg/L PBTK NA 95% Human Human -DTXSID1040459 Clint NA 3.265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040459 Fup NA 0.1669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040459 Vd NA 0.3171 L/kg 1compartment NA NA Rat Human +DTXSID1040459 TK.Half.Life NA 2.745 hours 1compartment NA NA Human Human +DTXSID1040459 Css NA 0.214 mg/L 3compartmentss NA 50% Human Human +DTXSID1040459 Css NA 1.501 mg/L 3compartmentss NA 95% Human Human +DTXSID1040459 Css NA 0.1442 mg/L PBTK NA 50% Human Human +DTXSID1040459 Css NA 0.9451 mg/L PBTK NA 95% Human Human +DTXSID1040459 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040459 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040459 Vd NA 0.5931 L/kg 1compartment NA NA Rat Human DTXSID1040459 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040459 TK.Half.Life NA 1.218 hours 1compartment NA NA Rat Human -DTXSID1040459 Css NA 0.4252 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040459 Css NA 1.582 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040459 Css NA 0.2538 mg/L PBTK NA 50% Rat Human -DTXSID1040459 Css NA 0.9003 mg/L PBTK NA 95% Rat Human -DTXSID1040611 Clint NA 827.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040611 Fup NA 0.0042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040611 Vd NA 158.5 L/kg 1compartment NA NA Human Human -DTXSID1040611 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID1040611 TK.Half.Life NA 129.2 hours 1compartment NA NA Human Human -DTXSID1040611 Css NA 0.003243 mg/L 3compartmentss NA 50% Human Human -DTXSID1040611 Css NA 0.02046 mg/L 3compartmentss NA 95% Human Human -DTXSID1040611 Css NA 0.0658 mg/L PBTK NA 50% Human Human -DTXSID1040611 Css NA 0.3733 mg/L PBTK NA 95% Human Human -DTXSID1040611 Clint NA 827.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040611 Fup NA 0.0042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040611 Vd NA 139 L/kg 1compartment NA NA Rat Human -DTXSID1040611 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID1040611 TK.Half.Life NA 21.78 hours 1compartment NA NA Rat Human -DTXSID1040611 Css NA 0.001638 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040611 Css NA 0.007304 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040611 Css NA 0.03567 mg/L PBTK NA 50% Rat Human -DTXSID1040611 Css NA 0.1621 mg/L PBTK NA 95% Rat Human -DTXSID1040617 Clint NA 7.727 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1040459 TK.Half.Life NA 1.317 hours 1compartment NA NA Rat Human +DTXSID1040459 Css NA 0.002082 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040459 Css NA 0.012 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040459 Css NA 0.001324 mg/L PBTK NA 50% Rat Human +DTXSID1040459 Css NA 0.007146 mg/L PBTK NA 95% Rat Human +DTXSID1040586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040586 Fup 0.0274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040586 Vd NA 66.99 L/kg 1compartment NA NA Human Human +DTXSID1040586 Days.Css NA 506 Days PBTK NA NA Human Human +DTXSID1040586 TK.Half.Life NA 1967 hours 1compartment NA NA Human Human +DTXSID1040586 Css NA 0.1662 mg/L 3compartmentss NA 50% Human Human +DTXSID1040586 Css NA 1.192 mg/L 3compartmentss NA 95% Human Human +DTXSID1040586 Css NA 1.289 mg/L PBTK NA 50% Human Human +DTXSID1040586 Css NA 8.184 mg/L PBTK NA 95% Human Human +DTXSID1040586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040586 Fup 0.0274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040586 Vd NA 57.1 L/kg 1compartment NA NA Rat Human +DTXSID1040586 Days.Css NA 316 Days PBTK NA NA Rat Human +DTXSID1040586 TK.Half.Life NA 285.7 hours 1compartment NA NA Rat Human +DTXSID1040586 Css NA 0.001638 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040586 Css NA 0.009896 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040586 Css NA 0.01355 mg/L PBTK NA 50% Rat Human +DTXSID1040586 Css NA 0.07911 mg/L PBTK NA 95% Rat Human +DTXSID1040617 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1040617 Fup 0.41 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1040617 Vd NA 0.8913 L/kg 1compartment NA NA Human Human +DTXSID1040617 Vd NA 0.8963 L/kg 1compartment NA NA Human Human DTXSID1040617 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040617 TK.Half.Life NA 1.579 hours 1compartment NA NA Human Human -DTXSID1040617 Css NA 0.1336 mg/L 3compartmentss NA 50% Human Human -DTXSID1040617 Css NA 0.9187 mg/L 3compartmentss NA 95% Human Human -DTXSID1040617 Css NA 0.1038 mg/L PBTK NA 50% Human Human -DTXSID1040617 Css NA 0.6299 mg/L PBTK NA 95% Human Human -DTXSID1040617 Clint NA 7.727 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1040617 TK.Half.Life NA 1.797 hours 1compartment NA NA Human Human +DTXSID1040617 Css NA 0.1543 mg/L 3compartmentss NA 50% Human Human +DTXSID1040617 Css NA 1.009 mg/L 3compartmentss NA 95% Human Human +DTXSID1040617 Css NA 0.1198 mg/L PBTK NA 50% Human Human +DTXSID1040617 Css NA 0.6953 mg/L PBTK NA 95% Human Human +DTXSID1040617 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1040617 Fup 0.41 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1040617 Vd NA 0.8115 L/kg 1compartment NA NA Rat Human +DTXSID1040617 Vd NA 0.8158 L/kg 1compartment NA NA Rat Human DTXSID1040617 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040617 TK.Half.Life NA 0.7833 hours 1compartment NA NA Rat Human -DTXSID1040617 Css NA 0.06808 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040617 Css NA 0.3552 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040617 Css NA 0.05072 mg/L PBTK NA 50% Rat Human -DTXSID1040617 Css NA 0.2234 mg/L PBTK NA 95% Rat Human -DTXSID1040619 Clint NA 8.013 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040619 Fup NA 0.0018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040619 Vd NA 2.137 L/kg 1compartment NA NA Human Human -DTXSID1040619 Days.Css NA 59 Days PBTK NA NA Human Human -DTXSID1040619 TK.Half.Life NA 271.1 hours 1compartment NA NA Human Human -DTXSID1040619 Css NA 21.68 mg/L 3compartmentss NA 50% Human Human -DTXSID1040619 Css NA 195.3 mg/L 3compartmentss NA 95% Human Human -DTXSID1040619 Css NA 13.93 mg/L PBTK NA 50% Human Human -DTXSID1040619 Css NA 119.5 mg/L PBTK NA 95% Human Human -DTXSID1040619 Clint NA 8.013 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040619 Fup NA 0.0018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040619 Vd NA 1.583 L/kg 1compartment NA NA Rat Human -DTXSID1040619 Days.Css NA 30 Days PBTK NA NA Rat Human -DTXSID1040619 TK.Half.Life NA 119.2 hours 1compartment NA NA Rat Human -DTXSID1040619 Css NA 12.14 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040619 Css NA 85.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040619 Css NA 7.319 mg/L PBTK NA 50% Rat Human -DTXSID1040619 Css NA 48.58 mg/L PBTK NA 95% Rat Human -DTXSID1040661 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040661 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040661 Vd NA 0.2399 L/kg 1compartment NA NA Human Human -DTXSID1040661 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID1040661 TK.Half.Life NA 45.51 hours 1compartment NA NA Human Human -DTXSID1040661 Css NA 33.84 mg/L 3compartmentss NA 50% Human Human -DTXSID1040661 Css NA 150.8 mg/L 3compartmentss NA 95% Human Human -DTXSID1040661 Css NA 20.19 mg/L PBTK NA 50% Human Human -DTXSID1040661 Css NA 87.74 mg/L PBTK NA 95% Human Human -DTXSID1040661 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040661 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040661 Vd NA 0.2344 L/kg 1compartment NA NA Rat Human -DTXSID1040661 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1040661 TK.Half.Life NA 15.16 hours 1compartment NA NA Rat Human -DTXSID1040661 Css NA 9.505 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040661 Css NA 36.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040661 Css NA 5.308 mg/L PBTK NA 50% Rat Human -DTXSID1040661 Css NA 19.74 mg/L PBTK NA 95% Rat Human +DTXSID1040617 TK.Half.Life NA 0.8954 hours 1compartment NA NA Rat Human +DTXSID1040617 Css NA 0.01813 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040617 Css NA 0.09427 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040617 Css NA 0.014 mg/L PBTK NA 50% Rat Human +DTXSID1040617 Css NA 0.0618 mg/L PBTK NA 95% Rat Human +DTXSID1040619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040619 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040619 Vd NA 8.932 L/kg 1compartment NA NA Human Human +DTXSID1040619 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID1040619 TK.Half.Life NA 128.6 hours 1compartment NA NA Human Human +DTXSID1040619 Css NA 1.344 mg/L 3compartmentss NA 50% Human Human +DTXSID1040619 Css NA 13.46 mg/L 3compartmentss NA 95% Human Human +DTXSID1040619 Css NA 1.417 mg/L PBTK NA 50% Human Human +DTXSID1040619 Css NA 11.01 mg/L PBTK NA 95% Human Human +DTXSID1040619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040619 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040619 Vd NA 7 L/kg 1compartment NA NA Rat Human +DTXSID1040619 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID1040619 TK.Half.Life NA 39.86 hours 1compartment NA NA Rat Human +DTXSID1040619 Css NA 0.1666 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040619 Css NA 1.377 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040619 Css NA 0.1792 mg/L PBTK NA 50% Rat Human +DTXSID1040619 Css NA 1.148 mg/L PBTK NA 95% Rat Human +DTXSID1040661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040661 Fup 0.0475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040661 Vd NA 0.2664 L/kg 1compartment NA NA Human Human +DTXSID1040661 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1040661 TK.Half.Life NA 1.219 hours 1compartment NA NA Human Human +DTXSID1040661 Css NA 0.6498 mg/L 3compartmentss NA 50% Human Human +DTXSID1040661 Css NA 5.588 mg/L 3compartmentss NA 95% Human Human +DTXSID1040661 Css NA 0.3957 mg/L PBTK NA 50% Human Human +DTXSID1040661 Css NA 3.317 mg/L PBTK NA 95% Human Human +DTXSID1040661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040661 Fup 0.0475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040661 Vd NA 0.2603 L/kg 1compartment NA NA Rat Human +DTXSID1040661 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1040661 TK.Half.Life NA 0.7508 hours 1compartment NA NA Rat Human +DTXSID1040661 Css NA 0.08577 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040661 Css NA 0.573 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040661 Css NA 0.05048 mg/L PBTK NA 50% Rat Human +DTXSID1040661 Css NA 0.3278 mg/L PBTK NA 95% Rat Human DTXSID1040667 Clint NA 14.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1040667 Fup NA 0.5462 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1040667 Vd NA 1.051 L/kg 1compartment NA NA Human Human DTXSID1040667 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1040667 TK.Half.Life NA 1.124 hours 1compartment NA NA Human Human -DTXSID1040667 Css NA 0.05393 mg/L 3compartmentss NA 50% Human Human -DTXSID1040667 Css NA 0.5225 mg/L 3compartmentss NA 95% Human Human -DTXSID1040667 Css NA 0.04448 mg/L PBTK NA 50% Human Human -DTXSID1040667 Css NA 0.3586 mg/L PBTK NA 95% Human Human +DTXSID1040667 Css NA 0.05089 mg/L 3compartmentss NA 50% Human Human +DTXSID1040667 Css NA 0.5002 mg/L 3compartmentss NA 95% Human Human +DTXSID1040667 Css NA 0.04244 mg/L PBTK NA 50% Human Human +DTXSID1040667 Css NA 0.3476 mg/L PBTK NA 95% Human Human DTXSID1040667 Clint NA 14.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1040667 Fup NA 0.5462 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1040667 Vd NA 0.9605 L/kg 1compartment NA NA Rat Human DTXSID1040667 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1040667 TK.Half.Life NA 0.5243 hours 1compartment NA NA Rat Human -DTXSID1040667 Css NA 0.02824 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040667 Css NA 0.2329 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040667 Css NA 0.02268 mg/L PBTK NA 50% Rat Human -DTXSID1040667 Css NA 0.1455 mg/L PBTK NA 95% Rat Human -DTXSID1040740 Clint NA 0.8113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040740 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040740 Vd NA 0.923 L/kg 1compartment NA NA Human Human +DTXSID1040667 Css NA 0.006206 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040667 Css NA 0.0505 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040667 Css NA 0.005141 mg/L PBTK NA 50% Rat Human +DTXSID1040667 Css NA 0.03364 mg/L PBTK NA 95% Rat Human +DTXSID1040740 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040740 Fup 0.498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040740 Vd NA 0.569 L/kg 1compartment NA NA Human Human DTXSID1040740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040740 TK.Half.Life NA 2.731 hours 1compartment NA NA Human Human -DTXSID1040740 Css NA 0.3415 mg/L 3compartmentss NA 50% Human Human -DTXSID1040740 Css NA 2.429 mg/L 3compartmentss NA 95% Human Human -DTXSID1040740 Css NA 0.2968 mg/L PBTK NA 50% Human Human -DTXSID1040740 Css NA 1.635 mg/L PBTK NA 95% Human Human -DTXSID1040740 Clint NA 0.8113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040740 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040740 Vd NA 0.9394 L/kg 1compartment NA NA Rat Human +DTXSID1040740 TK.Half.Life NA 7.401 hours 1compartment NA NA Human Human +DTXSID1040740 Css NA 1.238 mg/L 3compartmentss NA 50% Human Human +DTXSID1040740 Css NA 6.334 mg/L 3compartmentss NA 95% Human Human +DTXSID1040740 Css NA 0.9324 mg/L PBTK NA 50% Human Human +DTXSID1040740 Css NA 4.043 mg/L PBTK NA 95% Human Human +DTXSID1040740 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040740 Fup 0.498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040740 Vd NA 0.5841 L/kg 1compartment NA NA Rat Human DTXSID1040740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040740 TK.Half.Life NA 1.291 hours 1compartment NA NA Rat Human -DTXSID1040740 Css NA 0.1226 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040740 Css NA 0.8236 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040740 Css NA 0.1058 mg/L PBTK NA 50% Rat Human -DTXSID1040740 Css NA 0.4993 mg/L PBTK NA 95% Rat Human +DTXSID1040740 TK.Half.Life NA 2.587 hours 1compartment NA NA Rat Human +DTXSID1040740 Css NA 0.02325 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040740 Css NA 0.1643 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040740 Css NA 0.01705 mg/L PBTK NA 50% Rat Human +DTXSID1040740 Css NA 0.1049 mg/L PBTK NA 95% Rat Human DTXSID1040742 Clint 2.492 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1040742 Fup 0.7348 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1040742 Vd NA 0.7279 L/kg 1compartment NA NA Human Human DTXSID1040742 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1040742 TK.Half.Life NA 1.565 hours 1compartment NA NA Human Human -DTXSID1040742 Css NA 0.2222 mg/L 3compartmentss NA 50% Human Human -DTXSID1040742 Css NA 1.573 mg/L 3compartmentss NA 95% Human Human -DTXSID1040742 Css NA 0.1766 mg/L PBTK NA 50% Human Human -DTXSID1040742 Css NA 1.026 mg/L PBTK NA 95% Human Human +DTXSID1040742 Css NA 0.1024 mg/L 3compartmentss NA 50% Human Human +DTXSID1040742 Css NA 0.8236 mg/L 3compartmentss NA 95% Human Human +DTXSID1040742 Css NA 0.08092 mg/L PBTK NA 50% Human Human +DTXSID1040742 Css NA 0.5448 mg/L PBTK NA 95% Human Human DTXSID1040742 Clint 2.492 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1040742 Fup 0.7348 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1040742 Vd NA 0.7045 L/kg 1compartment NA NA Rat Human DTXSID1040742 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1040742 TK.Half.Life NA 0.7917 hours 1compartment NA NA Rat Human -DTXSID1040742 Css NA 0.09637 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040742 Css NA 0.6726 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040742 Css NA 0.07486 mg/L PBTK NA 50% Rat Human -DTXSID1040742 Css NA 0.3967 mg/L PBTK NA 95% Rat Human -DTXSID1040792 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040792 Fup NA 0.9477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040792 Vd NA 0.7958 L/kg 1compartment NA NA Human Human +DTXSID1040742 Css NA 0.0007842 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040742 Css NA 0.006239 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040742 Css NA 0.0006095 mg/L PBTK NA 50% Rat Human +DTXSID1040742 Css NA 0.003775 mg/L PBTK NA 95% Rat Human +DTXSID1040792 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040792 Fup 0.891 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040792 Vd NA 0.7623 L/kg 1compartment NA NA Human Human DTXSID1040792 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1040792 TK.Half.Life NA 5.441 hours 1compartment NA NA Human Human -DTXSID1040792 Css NA 0.8504 mg/L 3compartmentss NA 50% Human Human -DTXSID1040792 Css NA 3.082 mg/L 3compartmentss NA 95% Human Human -DTXSID1040792 Css NA 0.716 mg/L PBTK NA 50% Human Human -DTXSID1040792 Css NA 2.16 mg/L PBTK NA 95% Human Human -DTXSID1040792 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040792 Fup NA 0.9477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040792 Vd NA 0.827 L/kg 1compartment NA NA Rat Human +DTXSID1040792 TK.Half.Life NA 5.541 hours 1compartment NA NA Human Human +DTXSID1040792 Css NA 0.7945 mg/L 3compartmentss NA 50% Human Human +DTXSID1040792 Css NA 4.58 mg/L 3compartmentss NA 95% Human Human +DTXSID1040792 Css NA 0.6592 mg/L PBTK NA 50% Human Human +DTXSID1040792 Css NA 3.019 mg/L PBTK NA 95% Human Human +DTXSID1040792 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040792 Fup 0.891 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040792 Vd NA 0.7914 L/kg 1compartment NA NA Rat Human DTXSID1040792 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040792 TK.Half.Life NA 1.925 hours 1compartment NA NA Rat Human -DTXSID1040792 Css NA 0.219 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040792 Css NA 0.7058 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040792 Css NA 0.1802 mg/L PBTK NA 50% Rat Human -DTXSID1040792 Css NA 0.4594 mg/L PBTK NA 95% Rat Human -DTXSID1040794 Clint NA 9.228 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040794 Fup NA 0.0657 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1040794 Vd NA 1.728 L/kg 1compartment NA NA Human Human -DTXSID1040794 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1040794 TK.Half.Life NA 14.21 hours 1compartment NA NA Human Human -DTXSID1040794 Css NA 1.129 mg/L 3compartmentss NA 50% Human Human -DTXSID1040794 Css NA 6.761 mg/L 3compartmentss NA 95% Human Human -DTXSID1040794 Css NA 0.7432 mg/L PBTK NA 50% Human Human -DTXSID1040794 Css NA 4.229 mg/L PBTK NA 95% Human Human -DTXSID1040794 Clint NA 9.228 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040794 Fup NA 0.0657 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1040794 Vd NA 1.302 L/kg 1compartment NA NA Rat Human +DTXSID1040792 TK.Half.Life NA 1.959 hours 1compartment NA NA Rat Human +DTXSID1040792 Css NA 0.02065 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040792 Css NA 0.1352 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040792 Css NA 0.01659 mg/L PBTK NA 50% Rat Human +DTXSID1040792 Css NA 0.08749 mg/L PBTK NA 95% Rat Human +DTXSID1040794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040794 Fup 0.0575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1040794 Vd NA 1.768 L/kg 1compartment NA NA Human Human +DTXSID1040794 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1040794 TK.Half.Life NA 8.025 hours 1compartment NA NA Human Human +DTXSID1040794 Css NA 0.585 mg/L 3compartmentss NA 50% Human Human +DTXSID1040794 Css NA 4.248 mg/L 3compartmentss NA 95% Human Human +DTXSID1040794 Css NA 0.3807 mg/L PBTK NA 50% Human Human +DTXSID1040794 Css NA 2.671 mg/L PBTK NA 95% Human Human +DTXSID1040794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040794 Fup 0.0575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1040794 Vd NA 1.329 L/kg 1compartment NA NA Rat Human DTXSID1040794 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1040794 TK.Half.Life NA 5.063 hours 1compartment NA NA Rat Human -DTXSID1040794 Css NA 0.6072 mg/L 3compartmentss NA 50% Rat Human -DTXSID1040794 Css NA 2.742 mg/L 3compartmentss NA 95% Rat Human -DTXSID1040794 Css NA 0.3768 mg/L PBTK NA 50% Rat Human -DTXSID1040794 Css NA 1.634 mg/L PBTK NA 95% Rat Human -DTXSID1041132 Clint NA 9.632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041132 Fup NA 0.0738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041132 Vd NA 0.6301 L/kg 1compartment NA NA Human Human +DTXSID1040794 TK.Half.Life NA 2.856 hours 1compartment NA NA Rat Human +DTXSID1040794 Css NA 0.07563 mg/L 3compartmentss NA 50% Rat Human +DTXSID1040794 Css NA 0.431 mg/L 3compartmentss NA 95% Rat Human +DTXSID1040794 Css NA 0.04792 mg/L PBTK NA 50% Rat Human +DTXSID1040794 Css NA 0.2656 mg/L PBTK NA 95% Rat Human +DTXSID1041051 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID1041051 Fup 0.51 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1041051 Vd NA 3.032 L/kg 1compartment NA NA Human Human +DTXSID1041051 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1041051 TK.Half.Life NA 28.11 hours 1compartment NA NA Human Human +DTXSID1041051 Css NA 0.8435 mg/L 3compartmentss NA 50% Human Human +DTXSID1041051 Css NA 4.359 mg/L 3compartmentss NA 95% Human Human +DTXSID1041051 Css NA 0.6444 mg/L PBTK NA 50% Human Human +DTXSID1041051 Css NA 3.119 mg/L PBTK NA 95% Human Human +DTXSID1041051 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID1041051 Fup 0.51 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1041051 Vd NA 2.343 L/kg 1compartment NA NA Rat Human +DTXSID1041051 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1041051 TK.Half.Life NA 5.005 hours 1compartment NA NA Rat Human +DTXSID1041051 Css NA 0.03783 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041051 Css NA 0.2024 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041051 Css NA 0.02854 mg/L PBTK NA 50% Rat Human +DTXSID1041051 Css NA 0.1436 mg/L PBTK NA 95% Rat Human +DTXSID1041057 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041057 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1041057 Vd NA 3.05 L/kg 1compartment NA NA Human Human +DTXSID1041057 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1041057 TK.Half.Life NA 36.81 hours 1compartment NA NA Human Human +DTXSID1041057 Css NA 1.388 mg/L 3compartmentss NA 50% Human Human +DTXSID1041057 Css NA 8.95 mg/L 3compartmentss NA 95% Human Human +DTXSID1041057 Css NA 0.9678 mg/L PBTK NA 50% Human Human +DTXSID1041057 Css NA 6.06 mg/L PBTK NA 95% Human Human +DTXSID1041057 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041057 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1041057 Vd NA 2.289 L/kg 1compartment NA NA Rat Human +DTXSID1041057 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1041057 TK.Half.Life NA 5.738 hours 1compartment NA NA Rat Human +DTXSID1041057 Css NA 0.1778 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041057 Css NA 1.013 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041057 Css NA 0.1228 mg/L PBTK NA 50% Rat Human +DTXSID1041057 Css NA 0.6701 mg/L PBTK NA 95% Rat Human +DTXSID1041132 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041132 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041132 Vd NA 0.6434 L/kg 1compartment NA NA Human Human DTXSID1041132 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041132 TK.Half.Life NA 3.715 hours 1compartment NA NA Human Human -DTXSID1041132 Css NA 0.8772 mg/L 3compartmentss NA 50% Human Human -DTXSID1041132 Css NA 6.27 mg/L 3compartmentss NA 95% Human Human -DTXSID1041132 Css NA 0.5433 mg/L PBTK NA 50% Human Human -DTXSID1041132 Css NA 3.736 mg/L PBTK NA 95% Human Human -DTXSID1041132 Clint NA 9.632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041132 Fup NA 0.0738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041132 Vd NA 0.5137 L/kg 1compartment NA NA Rat Human +DTXSID1041132 TK.Half.Life NA 1.12 hours 1compartment NA NA Human Human +DTXSID1041132 Css NA 0.1174 mg/L 3compartmentss NA 50% Human Human +DTXSID1041132 Css NA 0.8557 mg/L 3compartmentss NA 95% Human Human +DTXSID1041132 Css NA 0.07917 mg/L PBTK NA 50% Human Human +DTXSID1041132 Css NA 0.5512 mg/L PBTK NA 95% Human Human +DTXSID1041132 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041132 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041132 Vd NA 0.5684 L/kg 1compartment NA NA Rat Human DTXSID1041132 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041132 TK.Half.Life NA 1.835 hours 1compartment NA NA Rat Human -DTXSID1041132 Css NA 0.4789 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041132 Css NA 2.525 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041132 Css NA 0.28 mg/L PBTK NA 50% Rat Human -DTXSID1041132 Css NA 1.416 mg/L PBTK NA 95% Rat Human -DTXSID1041188 Clint NA 3.414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041188 Fup NA 0.2517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041188 Vd NA 1.893 L/kg 1compartment NA NA Human Human +DTXSID1041132 TK.Half.Life NA 0.5471 hours 1compartment NA NA Rat Human +DTXSID1041132 Css NA 0.01532 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041132 Css NA 0.0818 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041132 Css NA 0.01018 mg/L PBTK NA 50% Rat Human +DTXSID1041132 Css NA 0.05157 mg/L PBTK NA 95% Rat Human +DTXSID1041188 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041188 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041188 Vd NA 1.467 L/kg 1compartment NA NA Human Human DTXSID1041188 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041188 TK.Half.Life NA 11.53 hours 1compartment NA NA Human Human -DTXSID1041188 Css NA 0.6453 mg/L 3compartmentss NA 50% Human Human -DTXSID1041188 Css NA 3.173 mg/L 3compartmentss NA 95% Human Human -DTXSID1041188 Css NA 0.4806 mg/L PBTK NA 50% Human Human -DTXSID1041188 Css NA 2.192 mg/L PBTK NA 95% Human Human -DTXSID1041188 Clint NA 3.414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041188 Fup NA 0.2517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041188 Vd NA 1.48 L/kg 1compartment NA NA Rat Human +DTXSID1041188 TK.Half.Life NA 3.288 hours 1compartment NA NA Human Human +DTXSID1041188 Css NA 0.2066 mg/L 3compartmentss NA 50% Human Human +DTXSID1041188 Css NA 1.671 mg/L 3compartmentss NA 95% Human Human +DTXSID1041188 Css NA 0.1405 mg/L PBTK NA 50% Human Human +DTXSID1041188 Css NA 1.061 mg/L PBTK NA 95% Human Human +DTXSID1041188 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041188 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041188 Vd NA 1.139 L/kg 1compartment NA NA Rat Human DTXSID1041188 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041188 TK.Half.Life NA 3.859 hours 1compartment NA NA Rat Human -DTXSID1041188 Css NA 0.3142 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041188 Css NA 1.146 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041188 Css NA 0.2245 mg/L PBTK NA 50% Rat Human -DTXSID1041188 Css NA 0.7328 mg/L PBTK NA 95% Rat Human +DTXSID1041188 TK.Half.Life NA 1.289 hours 1compartment NA NA Rat Human +DTXSID1041188 Css NA 0.0264 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041188 Css NA 0.1548 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041188 Css NA 0.01775 mg/L PBTK NA 50% Rat Human +DTXSID1041188 Css NA 0.09808 mg/L PBTK NA 95% Rat Human DTXSID1041217 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1041217 Fup NA 0.2782 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1041217 Vd NA 1.346 L/kg 1compartment NA NA Human Human DTXSID1041217 Days.Css NA 5 Days PBTK NA NA Human Human DTXSID1041217 TK.Half.Life NA 38.11 hours 1compartment NA NA Human Human -DTXSID1041217 Css NA 3.111 mg/L 3compartmentss NA 50% Human Human -DTXSID1041217 Css NA 11.81 mg/L 3compartmentss NA 95% Human Human -DTXSID1041217 Css NA 2.337 mg/L PBTK NA 50% Human Human -DTXSID1041217 Css NA 7.702 mg/L PBTK NA 95% Human Human +DTXSID1041217 Css NA 3.035 mg/L 3compartmentss NA 50% Human Human +DTXSID1041217 Css NA 11.22 mg/L 3compartmentss NA 95% Human Human +DTXSID1041217 Css NA 2.273 mg/L PBTK NA 50% Human Human +DTXSID1041217 Css NA 7.367 mg/L PBTK NA 95% Human Human DTXSID1041217 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1041217 Fup NA 0.2782 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1041217 Vd NA 1.098 L/kg 1compartment NA NA Rat Human DTXSID1041217 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID1041217 TK.Half.Life NA 9.153 hours 1compartment NA NA Rat Human -DTXSID1041217 Css NA 0.8513 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041217 Css NA 2.657 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041217 Css NA 0.6105 mg/L PBTK NA 50% Rat Human -DTXSID1041217 Css NA 1.613 mg/L PBTK NA 95% Rat Human -DTXSID1041261 Clint NA 4.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041261 Fup NA 0.6749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041261 Vd NA 0.9545 L/kg 1compartment NA NA Human Human +DTXSID1041217 Css NA 0.1914 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041217 Css NA 0.6021 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041217 Css NA 0.1422 mg/L PBTK NA 50% Rat Human +DTXSID1041217 Css NA 0.3779 mg/L PBTK NA 95% Rat Human +DTXSID1041261 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041261 Fup 0.663 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041261 Vd NA 1.379 L/kg 1compartment NA NA Human Human DTXSID1041261 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041261 TK.Half.Life NA 1.542 hours 1compartment NA NA Human Human -DTXSID1041261 Css NA 0.1358 mg/L 3compartmentss NA 50% Human Human -DTXSID1041261 Css NA 1.161 mg/L 3compartmentss NA 95% Human Human -DTXSID1041261 Css NA 0.1138 mg/L PBTK NA 50% Human Human -DTXSID1041261 Css NA 0.7848 mg/L PBTK NA 95% Human Human -DTXSID1041261 Clint NA 4.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041261 Fup NA 0.6749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041261 Vd NA 0.9157 L/kg 1compartment NA NA Rat Human +DTXSID1041261 TK.Half.Life NA 1.167 hours 1compartment NA NA Human Human +DTXSID1041261 Css NA 0.02953 mg/L 3compartmentss NA 50% Human Human +DTXSID1041261 Css NA 0.3337 mg/L 3compartmentss NA 95% Human Human +DTXSID1041261 Css NA 0.02577 mg/L PBTK NA 50% Human Human +DTXSID1041261 Css NA 0.2409 mg/L PBTK NA 95% Human Human +DTXSID1041261 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041261 Fup 0.663 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041261 Vd NA 1.221 L/kg 1compartment NA NA Rat Human DTXSID1041261 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041261 TK.Half.Life NA 0.79 hours 1compartment NA NA Rat Human -DTXSID1041261 Css NA 0.06264 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041261 Css NA 0.4802 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041261 Css NA 0.05154 mg/L PBTK NA 50% Rat Human -DTXSID1041261 Css NA 0.2986 mg/L PBTK NA 95% Rat Human -DTXSID1041263 Clint NA 10.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041263 Fup NA 0.191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041263 Vd NA 2.443 L/kg 1compartment NA NA Human Human +DTXSID1041261 TK.Half.Life NA 0.4969 hours 1compartment NA NA Rat Human +DTXSID1041261 Css NA 0.003581 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041261 Css NA 0.03399 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041261 Css NA 0.003189 mg/L PBTK NA 50% Rat Human +DTXSID1041261 Css NA 0.0239 mg/L PBTK NA 95% Rat Human +DTXSID1041263 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041263 Fup 0.0741 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041263 Vd NA 1.819 L/kg 1compartment NA NA Human Human DTXSID1041263 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041263 TK.Half.Life NA 11.21 hours 1compartment NA NA Human Human -DTXSID1041263 Css NA 0.4749 mg/L 3compartmentss NA 50% Human Human -DTXSID1041263 Css NA 2.726 mg/L 3compartmentss NA 95% Human Human -DTXSID1041263 Css NA 0.3454 mg/L PBTK NA 50% Human Human -DTXSID1041263 Css NA 1.875 mg/L PBTK NA 95% Human Human -DTXSID1041263 Clint NA 10.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041263 Fup NA 0.191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041263 Vd NA 1.861 L/kg 1compartment NA NA Rat Human +DTXSID1041263 TK.Half.Life NA 6.985 hours 1compartment NA NA Human Human +DTXSID1041263 Css NA 0.4566 mg/L 3compartmentss NA 50% Human Human +DTXSID1041263 Css NA 3.238 mg/L 3compartmentss NA 95% Human Human +DTXSID1041263 Css NA 0.303 mg/L PBTK NA 50% Human Human +DTXSID1041263 Css NA 2.067 mg/L PBTK NA 95% Human Human +DTXSID1041263 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041263 Fup 0.0741 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041263 Vd NA 1.373 L/kg 1compartment NA NA Rat Human DTXSID1041263 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041263 TK.Half.Life NA 3.043 hours 1compartment NA NA Rat Human -DTXSID1041263 Css NA 0.252 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041263 Css NA 1.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041263 Css NA 0.1752 mg/L PBTK NA 50% Rat Human -DTXSID1041263 Css NA 0.7147 mg/L PBTK NA 95% Rat Human -DTXSID1041265 Clint NA 8.339 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041265 Fup NA 0.0166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041265 Vd NA 7.098 L/kg 1compartment NA NA Human Human -DTXSID1041265 Days.Css NA 127 Days PBTK NA NA Human Human -DTXSID1041265 TK.Half.Life NA 546.2 hours 1compartment NA NA Human Human -DTXSID1041265 Css NA 6.577 mg/L 3compartmentss NA 50% Human Human -DTXSID1041265 Css NA 37.41 mg/L 3compartmentss NA 95% Human Human -DTXSID1041265 Css NA 6.32 mg/L PBTK NA 50% Human Human -DTXSID1041265 Css NA 34.24 mg/L PBTK NA 95% Human Human -DTXSID1041265 Clint NA 8.339 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041265 Fup NA 0.0166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041265 Vd NA 5.503 L/kg 1compartment NA NA Rat Human -DTXSID1041265 Days.Css NA 72 Days PBTK NA NA Rat Human -DTXSID1041265 TK.Half.Life NA 73.51 hours 1compartment NA NA Rat Human -DTXSID1041265 Css NA 3.62 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041265 Css NA 15.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041265 Css NA 3.44 mg/L PBTK NA 50% Rat Human -DTXSID1041265 Css NA 14.43 mg/L PBTK NA 95% Rat Human -DTXSID1041267 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041267 Fup NA 0.9084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041267 Vd NA 0.9616 L/kg 1compartment NA NA Human Human +DTXSID1041263 TK.Half.Life NA 2.454 hours 1compartment NA NA Rat Human +DTXSID1041263 Css NA 0.05908 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041263 Css NA 0.3392 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041263 Css NA 0.03803 mg/L PBTK NA 50% Rat Human +DTXSID1041263 Css NA 0.2093 mg/L PBTK NA 95% Rat Human +DTXSID1041267 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041267 Fup 0.643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041267 Vd NA 1.191 L/kg 1compartment NA NA Human Human DTXSID1041267 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041267 TK.Half.Life NA 6.933 hours 1compartment NA NA Human Human -DTXSID1041267 Css NA 0.886 mg/L 3compartmentss NA 50% Human Human -DTXSID1041267 Css NA 4.885 mg/L 3compartmentss NA 95% Human Human -DTXSID1041267 Css NA 0.7685 mg/L PBTK NA 50% Human Human -DTXSID1041267 Css NA 3.307 mg/L PBTK NA 95% Human Human -DTXSID1041267 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041267 Fup NA 0.9084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041267 Vd NA 0.9598 L/kg 1compartment NA NA Rat Human +DTXSID1041267 TK.Half.Life NA 1.016 hours 1compartment NA NA Human Human +DTXSID1041267 Css NA 0.02366 mg/L 3compartmentss NA 50% Human Human +DTXSID1041267 Css NA 0.2959 mg/L 3compartmentss NA 95% Human Human +DTXSID1041267 Css NA 0.02012 mg/L PBTK NA 50% Human Human +DTXSID1041267 Css NA 0.2121 mg/L PBTK NA 95% Human Human +DTXSID1041267 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041267 Fup 0.643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041267 Vd NA 1.083 L/kg 1compartment NA NA Rat Human DTXSID1041267 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041267 TK.Half.Life NA 2.336 hours 1compartment NA NA Rat Human -DTXSID1041267 Css NA 0.2236 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041267 Css NA 1.319 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041267 Css NA 0.19 mg/L PBTK NA 50% Rat Human -DTXSID1041267 Css NA 0.8086 mg/L PBTK NA 95% Rat Human -DTXSID1041346 Clint NA 42.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041346 Fup NA 0.0538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041346 Vd NA 1.671 L/kg 1compartment NA NA Human Human +DTXSID1041267 TK.Half.Life NA 0.451 hours 1compartment NA NA Rat Human +DTXSID1041267 Css NA 0.0008441 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041267 Css NA 0.01241 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041267 Css NA 0.0007114 mg/L PBTK NA 50% Rat Human +DTXSID1041267 Css NA 0.008467 mg/L PBTK NA 95% Rat Human +DTXSID1041346 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041346 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041346 Vd NA 2.173 L/kg 1compartment NA NA Human Human DTXSID1041346 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041346 TK.Half.Life NA 4.693 hours 1compartment NA NA Human Human -DTXSID1041346 Css NA 0.3177 mg/L 3compartmentss NA 50% Human Human -DTXSID1041346 Css NA 2.513 mg/L 3compartmentss NA 95% Human Human -DTXSID1041346 Css NA 0.2056 mg/L PBTK NA 50% Human Human -DTXSID1041346 Css NA 1.563 mg/L PBTK NA 95% Human Human -DTXSID1041346 Clint NA 42.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041346 Fup NA 0.0538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041346 Vd NA 1.256 L/kg 1compartment NA NA Rat Human +DTXSID1041346 TK.Half.Life NA 6.96 hours 1compartment NA NA Human Human +DTXSID1041346 Css NA 0.3377 mg/L 3compartmentss NA 50% Human Human +DTXSID1041346 Css NA 2.283 mg/L 3compartmentss NA 95% Human Human +DTXSID1041346 Css NA 0.232 mg/L PBTK NA 50% Human Human +DTXSID1041346 Css NA 1.491 mg/L PBTK NA 95% Human Human +DTXSID1041346 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041346 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041346 Vd NA 1.647 L/kg 1compartment NA NA Rat Human DTXSID1041346 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041346 TK.Half.Life NA 1.707 hours 1compartment NA NA Rat Human -DTXSID1041346 Css NA 0.1811 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041346 Css NA 1.151 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041346 Css NA 0.1102 mg/L PBTK NA 50% Rat Human -DTXSID1041346 Css NA 0.6711 mg/L PBTK NA 95% Rat Human -DTXSID1041421 Clint NA 47.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041421 Fup NA 0.2021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041421 Vd NA 0.9538 L/kg 1compartment NA NA Human Human +DTXSID1041346 TK.Half.Life NA 2.172 hours 1compartment NA NA Rat Human +DTXSID1041346 Css NA 0.04267 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041346 Css NA 0.2394 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041346 Css NA 0.02896 mg/L PBTK NA 50% Rat Human +DTXSID1041346 Css NA 0.1575 mg/L PBTK NA 95% Rat Human +DTXSID1041421 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041421 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041421 Vd NA 1.224 L/kg 1compartment NA NA Human Human DTXSID1041421 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041421 TK.Half.Life NA 1.14 hours 1compartment NA NA Human Human -DTXSID1041421 Css NA 0.05309 mg/L 3compartmentss NA 50% Human Human -DTXSID1041421 Css NA 0.394 mg/L 3compartmentss NA 95% Human Human -DTXSID1041421 Css NA 0.03728 mg/L PBTK NA 50% Human Human -DTXSID1041421 Css NA 0.2585 mg/L PBTK NA 95% Human Human -DTXSID1041421 Clint NA 47.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041421 Fup NA 0.2021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041421 Vd NA 0.7942 L/kg 1compartment NA NA Rat Human +DTXSID1041421 TK.Half.Life NA 1.869 hours 1compartment NA NA Human Human +DTXSID1041421 Css NA 0.09326 mg/L 3compartmentss NA 50% Human Human +DTXSID1041421 Css NA 0.674 mg/L 3compartmentss NA 95% Human Human +DTXSID1041421 Css NA 0.06784 mg/L PBTK NA 50% Human Human +DTXSID1041421 Css NA 0.4561 mg/L PBTK NA 95% Human Human +DTXSID1041421 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041421 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041421 Vd NA 0.9984 L/kg 1compartment NA NA Rat Human DTXSID1041421 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041421 TK.Half.Life NA 0.477 hours 1compartment NA NA Rat Human -DTXSID1041421 Css NA 0.0294 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041421 Css NA 0.1645 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041421 Css NA 0.01963 mg/L PBTK NA 50% Rat Human -DTXSID1041421 Css NA 0.1032 mg/L PBTK NA 95% Rat Human -DTXSID1041423 Clint NA 0.2431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041423 Fup NA 0.9006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041423 Vd NA 0.8899 L/kg 1compartment NA NA Human Human -DTXSID1041423 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041423 TK.Half.Life NA 4.615 hours 1compartment NA NA Human Human -DTXSID1041423 Css NA 0.6046 mg/L 3compartmentss NA 50% Human Human -DTXSID1041423 Css NA 2.405 mg/L 3compartmentss NA 95% Human Human -DTXSID1041423 Css NA 0.5152 mg/L PBTK NA 50% Human Human -DTXSID1041423 Css NA 1.685 mg/L PBTK NA 95% Human Human -DTXSID1041423 Clint NA 0.2431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041423 Fup NA 0.9006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041423 Vd NA 0.9114 L/kg 1compartment NA NA Rat Human +DTXSID1041421 TK.Half.Life NA 0.7837 hours 1compartment NA NA Rat Human +DTXSID1041421 Css NA 0.01161 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041421 Css NA 0.06241 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041421 Css NA 0.008411 mg/L PBTK NA 50% Rat Human +DTXSID1041421 Css NA 0.04202 mg/L PBTK NA 95% Rat Human +DTXSID1041423 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041423 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041423 Vd NA 1.258 L/kg 1compartment NA NA Human Human +DTXSID1041423 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1041423 TK.Half.Life NA 14.19 hours 1compartment NA NA Human Human +DTXSID1041423 Css NA 1.129 mg/L 3compartmentss NA 50% Human Human +DTXSID1041423 Css NA 7.837 mg/L 3compartmentss NA 95% Human Human +DTXSID1041423 Css NA 0.9818 mg/L PBTK NA 50% Human Human +DTXSID1041423 Css NA 5.085 mg/L PBTK NA 95% Human Human +DTXSID1041423 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041423 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041423 Vd NA 1.158 L/kg 1compartment NA NA Rat Human DTXSID1041423 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041423 TK.Half.Life NA 1.874 hours 1compartment NA NA Rat Human -DTXSID1041423 Css NA 0.1842 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041423 Css NA 0.6809 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041423 Css NA 0.1545 mg/L PBTK NA 50% Rat Human -DTXSID1041423 Css NA 0.4418 mg/L PBTK NA 95% Rat Human -DTXSID1041502 Clint NA 79.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041502 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041502 Vd NA 3.019 L/kg 1compartment NA NA Human Human -DTXSID1041502 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1041502 TK.Half.Life NA 18.73 hours 1compartment NA NA Human Human -DTXSID1041502 Css NA 0.7098 mg/L 3compartmentss NA 50% Human Human -DTXSID1041502 Css NA 4.486 mg/L 3compartmentss NA 95% Human Human -DTXSID1041502 Css NA 0.4895 mg/L PBTK NA 50% Human Human -DTXSID1041502 Css NA 2.986 mg/L PBTK NA 95% Human Human -DTXSID1041502 Clint NA 79.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041502 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041502 Vd NA 2.262 L/kg 1compartment NA NA Rat Human -DTXSID1041502 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041502 TK.Half.Life NA 3.234 hours 1compartment NA NA Rat Human -DTXSID1041502 Css NA 0.3978 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041502 Css NA 2.156 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041502 Css NA 0.2619 mg/L PBTK NA 50% Rat Human -DTXSID1041502 Css NA 1.391 mg/L PBTK NA 95% Rat Human -DTXSID1041506 Clint NA 38.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041506 Fup NA 0.0512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041506 Vd NA 2.55 L/kg 1compartment NA NA Human Human -DTXSID1041506 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041506 TK.Half.Life NA 11.47 hours 1compartment NA NA Human Human -DTXSID1041506 Css NA 0.5354 mg/L 3compartmentss NA 50% Human Human -DTXSID1041506 Css NA 3.684 mg/L 3compartmentss NA 95% Human Human -DTXSID1041506 Css NA 0.362 mg/L PBTK NA 50% Human Human -DTXSID1041506 Css NA 2.4 mg/L PBTK NA 95% Human Human -DTXSID1041506 Clint NA 38.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041506 Fup NA 0.0512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041506 Vd NA 1.912 L/kg 1compartment NA NA Rat Human -DTXSID1041506 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041506 TK.Half.Life NA 2.909 hours 1compartment NA NA Rat Human -DTXSID1041506 Css NA 0.3006 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041506 Css NA 1.719 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041506 Css NA 0.1929 mg/L PBTK NA 50% Rat Human -DTXSID1041506 Css NA 1.058 mg/L PBTK NA 95% Rat Human +DTXSID1041423 TK.Half.Life NA 4.219 hours 1compartment NA NA Rat Human +DTXSID1041423 Css NA 0.06879 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041423 Css NA 0.4504 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041423 Css NA 0.06006 mg/L PBTK NA 50% Rat Human +DTXSID1041423 Css NA 0.2821 mg/L PBTK NA 95% Rat Human +DTXSID1041506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041506 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041506 Vd NA 2.204 L/kg 1compartment NA NA Human Human +DTXSID1041506 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1041506 TK.Half.Life NA 20.58 hours 1compartment NA NA Human Human +DTXSID1041506 Css NA 1.327 mg/L 3compartmentss NA 50% Human Human +DTXSID1041506 Css NA 10.25 mg/L 3compartmentss NA 95% Human Human +DTXSID1041506 Css NA 0.863 mg/L PBTK NA 50% Human Human +DTXSID1041506 Css NA 6.318 mg/L PBTK NA 95% Human Human +DTXSID1041506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041506 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041506 Vd NA 1.643 L/kg 1compartment NA NA Rat Human +DTXSID1041506 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1041506 TK.Half.Life NA 6.048 hours 1compartment NA NA Rat Human +DTXSID1041506 Css NA 0.1708 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041506 Css NA 1.064 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041506 Css NA 0.1091 mg/L PBTK NA 50% Rat Human +DTXSID1041506 Css NA 0.6442 mg/L PBTK NA 95% Rat Human DTXSID1041508 Clint 19.5 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID1041508 Fup 0.1565 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID1041508 Vd NA 0.8768 L/kg 1compartment NA NA Rat Rat +DTXSID1041508 Vd NA 1.093 L/kg 1compartment NA NA Rat Rat DTXSID1041508 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID1041508 TK.Half.Life NA 0.9945 hours 1compartment NA NA Rat Rat -DTXSID1041508 Css NA 0.1033 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1041508 Css NA 0.6068 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1041508 Css NA 0.06662 mg/L PBTK NA 50% Rat Rat -DTXSID1041508 Css NA 0.3688 mg/L PBTK NA 95% Rat Rat -DTXSID1041550 Clint NA 17.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041550 Fup NA 0.1796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041550 Vd NA 2.998 L/kg 1compartment NA NA Human Human -DTXSID1041550 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1041550 TK.Half.Life NA 23.9 hours 1compartment NA NA Human Human -DTXSID1041550 Css NA 0.8785 mg/L 3compartmentss NA 50% Human Human -DTXSID1041550 Css NA 5.096 mg/L 3compartmentss NA 95% Human Human -DTXSID1041550 Css NA 0.623 mg/L PBTK NA 50% Human Human -DTXSID1041550 Css NA 3.496 mg/L PBTK NA 95% Human Human -DTXSID1041550 Clint NA 17.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041550 Fup NA 0.1796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041550 Vd NA 2.257 L/kg 1compartment NA NA Rat Human +DTXSID1041508 TK.Half.Life NA 1.236 hours 1compartment NA NA Rat Rat +DTXSID1041508 Css NA 0.02497 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1041508 Css NA 0.1348 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1041508 Css NA 0.01692 mg/L PBTK NA 50% Rat Rat +DTXSID1041508 Css NA 0.08627 mg/L PBTK NA 95% Rat Rat +DTXSID1041550 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041550 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041550 Vd NA 2.985 L/kg 1compartment NA NA Human Human +DTXSID1041550 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1041550 TK.Half.Life NA 19.46 hours 1compartment NA NA Human Human +DTXSID1041550 Css NA 0.6732 mg/L 3compartmentss NA 50% Human Human +DTXSID1041550 Css NA 4.271 mg/L 3compartmentss NA 95% Human Human +DTXSID1041550 Css NA 0.479 mg/L PBTK NA 50% Human Human +DTXSID1041550 Css NA 2.914 mg/L PBTK NA 95% Human Human +DTXSID1041550 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041550 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041550 Vd NA 2.248 L/kg 1compartment NA NA Rat Human DTXSID1041550 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1041550 TK.Half.Life NA 4.136 hours 1compartment NA NA Rat Human -DTXSID1041550 Css NA 0.4826 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041550 Css NA 2.299 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041550 Css NA 0.327 mg/L PBTK NA 50% Rat Human -DTXSID1041550 Css NA 1.538 mg/L PBTK NA 95% Rat Human -DTXSID1041639 Clint NA 0.5964 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041639 Fup NA 0.1798 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041639 Vd NA 0.4022 L/kg 1compartment NA NA Human Human +DTXSID1041550 TK.Half.Life NA 3.495 hours 1compartment NA NA Rat Human +DTXSID1041550 Css NA 0.08734 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041550 Css NA 0.4363 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041550 Css NA 0.06166 mg/L PBTK NA 50% Rat Human +DTXSID1041550 Css NA 0.2978 mg/L PBTK NA 95% Rat Human +DTXSID10415505 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10415505 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10415505 Vd NA 0.4744 L/kg 1compartment NA NA Human Human +DTXSID10415505 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10415505 TK.Half.Life NA 0.8176 hours 1compartment NA NA Human Human +DTXSID10415505 Css NA 0.07348 mg/L 3compartmentss NA 50% Human Human +DTXSID10415505 Css NA 0.5714 mg/L 3compartmentss NA 95% Human Human +DTXSID10415505 Css NA 0.0486 mg/L PBTK NA 50% Human Human +DTXSID10415505 Css NA 0.3653 mg/L PBTK NA 95% Human Human +DTXSID10415505 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10415505 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10415505 Vd NA 0.4498 L/kg 1compartment NA NA Rat Human +DTXSID10415505 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10415505 TK.Half.Life NA 0.4311 hours 1compartment NA NA Rat Human +DTXSID10415505 Css NA 0.001026 mg/L 3compartmentss NA 50% Rat Human +DTXSID10415505 Css NA 0.009425 mg/L 3compartmentss NA 95% Rat Human +DTXSID10415505 Css NA 0.0006477 mg/L PBTK NA 50% Rat Human +DTXSID10415505 Css NA 0.005803 mg/L PBTK NA 95% Rat Human +DTXSID1041639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041639 Fup 0.396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041639 Vd NA 0.4284 L/kg 1compartment NA NA Human Human DTXSID1041639 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041639 TK.Half.Life NA 7.306 hours 1compartment NA NA Human Human -DTXSID1041639 Css NA 2.217 mg/L 3compartmentss NA 50% Human Human -DTXSID1041639 Css NA 9.561 mg/L 3compartmentss NA 95% Human Human -DTXSID1041639 Css NA 1.477 mg/L PBTK NA 50% Human Human -DTXSID1041639 Css NA 5.875 mg/L PBTK NA 95% Human Human -DTXSID1041639 Clint NA 0.5964 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041639 Fup NA 0.1798 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041639 Vd NA 0.4047 L/kg 1compartment NA NA Rat Human +DTXSID1041639 TK.Half.Life NA 0.6466 hours 1compartment NA NA Human Human +DTXSID1041639 Css NA 0.09796 mg/L 3compartmentss NA 50% Human Human +DTXSID1041639 Css NA 0.6777 mg/L 3compartmentss NA 95% Human Human +DTXSID1041639 Css NA 0.06915 mg/L PBTK NA 50% Human Human +DTXSID1041639 Css NA 0.4444 mg/L PBTK NA 95% Human Human +DTXSID1041639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041639 Fup 0.396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041639 Vd NA 0.4531 L/kg 1compartment NA NA Rat Human DTXSID1041639 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041639 TK.Half.Life NA 3.352 hours 1compartment NA NA Rat Human -DTXSID1041639 Css NA 0.854 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041639 Css NA 2.812 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041639 Css NA 0.5373 mg/L PBTK NA 50% Rat Human -DTXSID1041639 Css NA 1.611 mg/L PBTK NA 95% Rat Human -DTXSID1041681 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041681 Fup NA 0.0139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041681 Vd NA 0.2258 L/kg 1compartment NA NA Human Human -DTXSID1041681 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID1041681 TK.Half.Life NA 105.1 hours 1compartment NA NA Human Human -DTXSID1041681 Css NA 79.09 mg/L 3compartmentss NA 50% Human Human -DTXSID1041681 Css NA 503.9 mg/L 3compartmentss NA 95% Human Human -DTXSID1041681 Css NA 46.99 mg/L PBTK NA 50% Human Human -DTXSID1041681 Css NA 288.3 mg/L PBTK NA 95% Human Human -DTXSID1041681 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041681 Fup NA 0.0139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041681 Vd NA 0.2191 L/kg 1compartment NA NA Rat Human -DTXSID1041681 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID1041681 TK.Half.Life NA 34.74 hours 1compartment NA NA Rat Human -DTXSID1041681 Css NA 22.82 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041681 Css NA 123 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041681 Css NA 12.6 mg/L PBTK NA 50% Rat Human -DTXSID1041681 Css NA 66.7 mg/L PBTK NA 95% Rat Human -DTXSID1041683 Clint NA 57.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041683 Fup NA 0.0116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041683 Vd NA 2.999 L/kg 1compartment NA NA Human Human -DTXSID1041683 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1041683 TK.Half.Life NA 28.55 hours 1compartment NA NA Human Human -DTXSID1041683 Css NA 1.148 mg/L 3compartmentss NA 50% Human Human -DTXSID1041683 Css NA 7.69 mg/L 3compartmentss NA 95% Human Human -DTXSID1041683 Css NA 0.783 mg/L PBTK NA 50% Human Human -DTXSID1041683 Css NA 5.138 mg/L PBTK NA 95% Human Human -DTXSID1041683 Clint NA 57.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041683 Fup NA 0.0116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041683 Vd NA 2.244 L/kg 1compartment NA NA Rat Human -DTXSID1041683 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1041683 TK.Half.Life NA 4.777 hours 1compartment NA NA Rat Human -DTXSID1041683 Css NA 0.6467 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041683 Css NA 3.529 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041683 Css NA 0.4227 mg/L PBTK NA 50% Rat Human -DTXSID1041683 Css NA 2.212 mg/L PBTK NA 95% Rat Human -DTXSID1041689 Clint NA 17.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041689 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041689 Vd NA 0.9532 L/kg 1compartment NA NA Human Human -DTXSID1041689 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1041689 TK.Half.Life NA 27.45 hours 1compartment NA NA Human Human -DTXSID1041689 Css NA 5.134 mg/L 3compartmentss NA 50% Human Human -DTXSID1041689 Css NA 49.26 mg/L 3compartmentss NA 95% Human Human -DTXSID1041689 Css NA 3.113 mg/L PBTK NA 50% Human Human -DTXSID1041689 Css NA 28.27 mg/L PBTK NA 95% Human Human -DTXSID1041689 Clint NA 17.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041689 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041689 Vd NA 0.714 L/kg 1compartment NA NA Rat Human -DTXSID1041689 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1041689 TK.Half.Life NA 12.56 hours 1compartment NA NA Rat Human -DTXSID1041689 Css NA 2.962 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041689 Css NA 21.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041689 Css NA 1.664 mg/L PBTK NA 50% Rat Human -DTXSID1041689 Css NA 12.01 mg/L PBTK NA 95% Rat Human +DTXSID1041639 TK.Half.Life NA 0.3697 hours 1compartment NA NA Rat Human +DTXSID1041639 Css NA 0.01167 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041639 Css NA 0.06441 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041639 Css NA 0.008126 mg/L PBTK NA 50% Rat Human +DTXSID1041639 Css NA 0.04109 mg/L PBTK NA 95% Rat Human +DTXSID1041681 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041681 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041681 Vd NA 0.2663 L/kg 1compartment NA NA Human Human +DTXSID1041681 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1041681 TK.Half.Life NA 6.46 hours 1compartment NA NA Human Human +DTXSID1041681 Css NA 3.709 mg/L 3compartmentss NA 50% Human Human +DTXSID1041681 Css NA 32.53 mg/L 3compartmentss NA 95% Human Human +DTXSID1041681 Css NA 2.238 mg/L PBTK NA 50% Human Human +DTXSID1041681 Css NA 19.1 mg/L PBTK NA 95% Human Human +DTXSID1041681 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041681 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041681 Vd NA 0.2581 L/kg 1compartment NA NA Rat Human +DTXSID1041681 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1041681 TK.Half.Life NA 3.965 hours 1compartment NA NA Rat Human +DTXSID1041681 Css NA 0.1714 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041681 Css NA 1.625 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041681 Css NA 0.09894 mg/L PBTK NA 50% Rat Human +DTXSID1041681 Css NA 0.911 mg/L PBTK NA 95% Rat Human +DTXSID1041689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041689 Fup 0.0375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041689 Vd NA 1.52 L/kg 1compartment NA NA Human Human +DTXSID1041689 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1041689 TK.Half.Life NA 5.514 hours 1compartment NA NA Human Human +DTXSID1041689 Css NA 0.4554 mg/L 3compartmentss NA 50% Human Human +DTXSID1041689 Css NA 4.676 mg/L 3compartmentss NA 95% Human Human +DTXSID1041689 Css NA 0.3166 mg/L PBTK NA 50% Human Human +DTXSID1041689 Css NA 2.946 mg/L PBTK NA 95% Human Human +DTXSID1041689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041689 Fup 0.0375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041689 Vd NA 1.44 L/kg 1compartment NA NA Rat Human +DTXSID1041689 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1041689 TK.Half.Life NA 3.199 hours 1compartment NA NA Rat Human +DTXSID1041689 Css NA 0.0603 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041689 Css NA 0.4895 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041689 Css NA 0.04108 mg/L PBTK NA 50% Rat Human +DTXSID1041689 Css NA 0.3027 mg/L PBTK NA 95% Rat Human DTXSID1041847 Clint 134 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1041847 Fup 7.05e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1041847 Vd NA 2.438 L/kg 1compartment NA NA Human Human -DTXSID1041847 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1041847 TK.Half.Life NA 18.91 hours 1compartment NA NA Human Human -DTXSID1041847 Css NA 0.59 mg/L 3compartmentss NA 50% Human Human -DTXSID1041847 Css NA 3.206 mg/L 3compartmentss NA 95% Human Human -DTXSID1041847 Css NA 0.4078 mg/L PBTK NA 50% Human Human -DTXSID1041847 Css NA 2.207 mg/L PBTK NA 95% Human Human +DTXSID1041847 Vd NA 3.303 L/kg 1compartment NA NA Human Human +DTXSID1041847 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1041847 TK.Half.Life NA 24.03 hours 1compartment NA NA Human Human +DTXSID1041847 Css NA 0.2811 mg/L 3compartmentss NA 50% Human Human +DTXSID1041847 Css NA 1.596 mg/L 3compartmentss NA 95% Human Human +DTXSID1041847 Css NA 0.2112 mg/L PBTK NA 50% Human Human +DTXSID1041847 Css NA 1.172 mg/L PBTK NA 95% Human Human DTXSID1041847 Clint 134 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1041847 Fup 7.05e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1041847 Vd NA 1.809 L/kg 1compartment NA NA Rat Human -DTXSID1041847 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041847 TK.Half.Life NA 9.442 hours 1compartment NA NA Rat Human -DTXSID1041847 Css NA 0.3316 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041847 Css NA 1.645 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041847 Css NA 0.2183 mg/L PBTK NA 50% Rat Human -DTXSID1041847 Css NA 1.123 mg/L PBTK NA 95% Rat Human -DTXSID1041897 Clint NA 13.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041897 Fup NA 0.9003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041897 Vd NA 1.319 L/kg 1compartment NA NA Human Human +DTXSID1041847 Vd NA 2.479 L/kg 1compartment NA NA Rat Human +DTXSID1041847 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1041847 TK.Half.Life NA 12.14 hours 1compartment NA NA Rat Human +DTXSID1041847 Css NA 0.002916 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041847 Css NA 0.01734 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041847 Css NA 0.002103 mg/L PBTK NA 50% Rat Human +DTXSID1041847 Css NA 0.0123 mg/L PBTK NA 95% Rat Human +DTXSID1041897 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041897 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041897 Vd NA 0.4161 L/kg 1compartment NA NA Human Human DTXSID1041897 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1041897 TK.Half.Life NA 0.9431 hours 1compartment NA NA Human Human -DTXSID1041897 Css NA 0.03196 mg/L 3compartmentss NA 50% Human Human -DTXSID1041897 Css NA 0.229 mg/L 3compartmentss NA 95% Human Human -DTXSID1041897 Css NA 0.03252 mg/L PBTK NA 50% Human Human -DTXSID1041897 Css NA 0.2027 mg/L PBTK NA 95% Human Human -DTXSID1041897 Clint NA 13.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041897 Fup NA 0.9003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041897 Vd NA 1.331 L/kg 1compartment NA NA Rat Human +DTXSID1041897 TK.Half.Life NA 2.492 hours 1compartment NA NA Human Human +DTXSID1041897 Css NA 0.8295 mg/L 3compartmentss NA 50% Human Human +DTXSID1041897 Css NA 5.736 mg/L 3compartmentss NA 95% Human Human +DTXSID1041897 Css NA 0.5347 mg/L PBTK NA 50% Human Human +DTXSID1041897 Css NA 3.456 mg/L PBTK NA 95% Human Human +DTXSID1041897 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041897 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041897 Vd NA 0.4111 L/kg 1compartment NA NA Rat Human DTXSID1041897 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041897 TK.Half.Life NA 0.4878 hours 1compartment NA NA Rat Human -DTXSID1041897 Css NA 0.0155 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041897 Css NA 0.09602 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041897 Css NA 0.01606 mg/L PBTK NA 50% Rat Human -DTXSID1041897 Css NA 0.08168 mg/L PBTK NA 95% Rat Human -DTXSID1041920 Clint NA 1.484 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041920 Fup NA 0.2915 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041920 Vd NA 1.788 L/kg 1compartment NA NA Human Human -DTXSID1041920 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1041920 TK.Half.Life NA 16.45 hours 1compartment NA NA Human Human -DTXSID1041920 Css NA 0.992 mg/L 3compartmentss NA 50% Human Human -DTXSID1041920 Css NA 4.287 mg/L 3compartmentss NA 95% Human Human -DTXSID1041920 Css NA 0.7528 mg/L PBTK NA 50% Human Human -DTXSID1041920 Css NA 2.918 mg/L PBTK NA 95% Human Human -DTXSID1041920 Clint NA 1.484 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041920 Fup NA 0.2915 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041920 Vd NA 1.416 L/kg 1compartment NA NA Rat Human +DTXSID1041897 TK.Half.Life NA 1.501 hours 1compartment NA NA Rat Human +DTXSID1041897 Css NA 0.09991 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041897 Css NA 0.5289 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041897 Css NA 0.06307 mg/L PBTK NA 50% Rat Human +DTXSID1041897 Css NA 0.3073 mg/L PBTK NA 95% Rat Human +DTXSID1041920 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041920 Fup 0.343 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041920 Vd NA 2.535 L/kg 1compartment NA NA Human Human +DTXSID1041920 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1041920 TK.Half.Life NA 4.748 hours 1compartment NA NA Human Human +DTXSID1041920 Css NA 0.1316 mg/L 3compartmentss NA 50% Human Human +DTXSID1041920 Css NA 0.8756 mg/L 3compartmentss NA 95% Human Human +DTXSID1041920 Css NA 0.1001 mg/L PBTK NA 50% Human Human +DTXSID1041920 Css NA 0.6255 mg/L PBTK NA 95% Human Human +DTXSID1041920 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041920 Fup 0.343 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041920 Vd NA 1.955 L/kg 1compartment NA NA Rat Human DTXSID1041920 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1041920 TK.Half.Life NA 5.271 hours 1compartment NA NA Rat Human -DTXSID1041920 Css NA 0.4309 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041920 Css NA 1.454 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041920 Css NA 0.3162 mg/L PBTK NA 50% Rat Human -DTXSID1041920 Css NA 0.9105 mg/L PBTK NA 95% Rat Human -DTXSID1041970 Clint NA 4.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041970 Fup NA 0.2453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041970 Vd NA 2.659 L/kg 1compartment NA NA Human Human -DTXSID1041970 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1041970 TK.Half.Life NA 27.11 hours 1compartment NA NA Human Human -DTXSID1041970 Css NA 1.134 mg/L 3compartmentss NA 50% Human Human -DTXSID1041970 Css NA 5.271 mg/L 3compartmentss NA 95% Human Human -DTXSID1041970 Css NA 0.8326 mg/L PBTK NA 50% Human Human -DTXSID1041970 Css NA 3.688 mg/L PBTK NA 95% Human Human -DTXSID1041970 Clint NA 4.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041970 Fup NA 0.2453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041970 Vd NA 2.026 L/kg 1compartment NA NA Rat Human -DTXSID1041970 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1041970 TK.Half.Life NA 5.955 hours 1compartment NA NA Rat Human -DTXSID1041970 Css NA 0.5665 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041970 Css NA 1.941 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041970 Css NA 0.4021 mg/L PBTK NA 50% Rat Human -DTXSID1041970 Css NA 1.273 mg/L PBTK NA 95% Rat Human -DTXSID1041978 Clint NA 33.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041978 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1041978 Vd NA 3.024 L/kg 1compartment NA NA Human Human -DTXSID1041978 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID1041978 TK.Half.Life NA 59.34 hours 1compartment NA NA Human Human -DTXSID1041978 Css NA 2.458 mg/L 3compartmentss NA 50% Human Human -DTXSID1041978 Css NA 14.67 mg/L 3compartmentss NA 95% Human Human -DTXSID1041978 Css NA 1.684 mg/L PBTK NA 50% Human Human -DTXSID1041978 Css NA 9.771 mg/L PBTK NA 95% Human Human -DTXSID1041978 Clint NA 33.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041978 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1041978 Vd NA 2.263 L/kg 1compartment NA NA Rat Human -DTXSID1041978 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1041978 TK.Half.Life NA 9.178 hours 1compartment NA NA Rat Human -DTXSID1041978 Css NA 1.38 mg/L 3compartmentss NA 50% Rat Human -DTXSID1041978 Css NA 6.386 mg/L 3compartmentss NA 95% Rat Human -DTXSID1041978 Css NA 0.905 mg/L PBTK NA 50% Rat Human -DTXSID1041978 Css NA 4.063 mg/L PBTK NA 95% Rat Human +DTXSID1041920 TK.Half.Life NA 1.362 hours 1compartment NA NA Rat Human +DTXSID1041920 Css NA 0.01645 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041920 Css NA 0.08261 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041920 Css NA 0.01254 mg/L PBTK NA 50% Rat Human +DTXSID1041920 Css NA 0.06 mg/L PBTK NA 95% Rat Human +DTXSID1041970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041970 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041970 Vd NA 2.643 L/kg 1compartment NA NA Human Human +DTXSID1041970 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1041970 TK.Half.Life NA 7.159 hours 1compartment NA NA Human Human +DTXSID1041970 Css NA 0.2297 mg/L 3compartmentss NA 50% Human Human +DTXSID1041970 Css NA 1.456 mg/L 3compartmentss NA 95% Human Human +DTXSID1041970 Css NA 0.1677 mg/L PBTK NA 50% Human Human +DTXSID1041970 Css NA 1.009 mg/L PBTK NA 95% Human Human +DTXSID1041970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041970 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041970 Vd NA 2.013 L/kg 1compartment NA NA Rat Human +DTXSID1041970 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1041970 TK.Half.Life NA 1.849 hours 1compartment NA NA Rat Human +DTXSID1041970 Css NA 0.02899 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041970 Css NA 0.1468 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041970 Css NA 0.0211 mg/L PBTK NA 50% Rat Human +DTXSID1041970 Css NA 0.1034 mg/L PBTK NA 95% Rat Human +DTXSID1041978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041978 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1041978 Vd NA 3.996 L/kg 1compartment NA NA Human Human +DTXSID1041978 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID1041978 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human +DTXSID1041978 Css NA 3.184 mg/L 3compartmentss NA 50% Human Human +DTXSID1041978 Css NA 19.3 mg/L 3compartmentss NA 95% Human Human +DTXSID1041978 Css NA 2.367 mg/L PBTK NA 50% Human Human +DTXSID1041978 Css NA 14.34 mg/L PBTK NA 95% Human Human +DTXSID1041978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041978 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1041978 Vd NA 3.022 L/kg 1compartment NA NA Rat Human +DTXSID1041978 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID1041978 TK.Half.Life NA 16.25 hours 1compartment NA NA Rat Human +DTXSID1041978 Css NA 0.4139 mg/L 3compartmentss NA 50% Rat Human +DTXSID1041978 Css NA 1.964 mg/L 3compartmentss NA 95% Rat Human +DTXSID1041978 Css NA 0.3066 mg/L PBTK NA 50% Rat Human +DTXSID1041978 Css NA 1.498 mg/L PBTK NA 95% Rat Human DTXSID1042077 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1042077 Fup 0.258 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1042077 Vd NA 2.142 L/kg 1compartment NA NA Human Human -DTXSID1042077 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID1042077 TK.Half.Life NA 103.3 hours 1compartment NA NA Human Human -DTXSID1042077 Css NA 5.091 mg/L 3compartmentss NA 50% Human Human -DTXSID1042077 Css NA 14.99 mg/L 3compartmentss NA 95% Human Human -DTXSID1042077 Css NA 3.832 mg/L PBTK NA 50% Human Human -DTXSID1042077 Css NA 10.15 mg/L PBTK NA 95% Human Human +DTXSID1042077 Vd NA 2.128 L/kg 1compartment NA NA Human Human +DTXSID1042077 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID1042077 TK.Half.Life NA 101.4 hours 1compartment NA NA Human Human +DTXSID1042077 Css NA 4.842 mg/L 3compartmentss NA 50% Human Human +DTXSID1042077 Css NA 14.15 mg/L 3compartmentss NA 95% Human Human +DTXSID1042077 Css NA 3.654 mg/L PBTK NA 50% Human Human +DTXSID1042077 Css NA 9.62 mg/L PBTK NA 95% Human Human DTXSID1042077 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1042077 Fup 0.258 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1042077 Vd NA 1.659 L/kg 1compartment NA NA Rat Human +DTXSID1042077 Vd NA 1.65 L/kg 1compartment NA NA Rat Human DTXSID1042077 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1042077 TK.Half.Life NA 17.29 hours 1compartment NA NA Rat Human -DTXSID1042077 Css NA 1.367 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042077 Css NA 3.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042077 Css NA 0.9928 mg/L PBTK NA 50% Rat Human -DTXSID1042077 Css NA 2.032 mg/L PBTK NA 95% Rat Human +DTXSID1042077 TK.Half.Life NA 17.13 hours 1compartment NA NA Rat Human +DTXSID1042077 Css NA 0.3071 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042077 Css NA 0.7211 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042077 Css NA 0.2308 mg/L PBTK NA 50% Rat Human +DTXSID1042077 Css NA 0.4711 mg/L PBTK NA 95% Rat Human DTXSID1042154 Clint 11.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1042154 Fup 0.0304 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1042154 Vd NA 0.4073 L/kg 1compartment NA NA Human Human +DTXSID1042154 Vd NA 0.4105 L/kg 1compartment NA NA Human Human DTXSID1042154 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1042154 TK.Half.Life NA 4.624 hours 1compartment NA NA Human Human -DTXSID1042154 Css NA 1.454 mg/L 3compartmentss NA 50% Human Human -DTXSID1042154 Css NA 10.85 mg/L 3compartmentss NA 95% Human Human -DTXSID1042154 Css NA 0.8873 mg/L PBTK NA 50% Human Human -DTXSID1042154 Css NA 6.431 mg/L PBTK NA 95% Human Human +DTXSID1042154 TK.Half.Life NA 4.658 hours 1compartment NA NA Human Human +DTXSID1042154 Css NA 1.411 mg/L 3compartmentss NA 50% Human Human +DTXSID1042154 Css NA 10.49 mg/L 3compartmentss NA 95% Human Human +DTXSID1042154 Css NA 0.855 mg/L PBTK NA 50% Human Human +DTXSID1042154 Css NA 6.127 mg/L PBTK NA 95% Human Human DTXSID1042154 Clint 11.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1042154 Fup 0.0304 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1042154 Vd NA 0.3345 L/kg 1compartment NA NA Rat Human +DTXSID1042154 Vd NA 0.3367 L/kg 1compartment NA NA Rat Human DTXSID1042154 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1042154 TK.Half.Life NA 2.421 hours 1compartment NA NA Rat Human -DTXSID1042154 Css NA 0.7907 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042154 Css NA 4.449 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042154 Css NA 0.4483 mg/L PBTK NA 50% Rat Human -DTXSID1042154 Css NA 2.456 mg/L PBTK NA 95% Rat Human -DTXSID1042281 Clint NA 0.1758 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042281 Fup NA 0.214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042281 Vd NA 0.4933 L/kg 1compartment NA NA Human Human +DTXSID1042154 TK.Half.Life NA 2.436 hours 1compartment NA NA Rat Human +DTXSID1042154 Css NA 0.1818 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042154 Css NA 0.9937 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042154 Css NA 0.107 mg/L PBTK NA 50% Rat Human +DTXSID1042154 Css NA 0.5709 mg/L PBTK NA 95% Rat Human +DTXSID1042281 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042281 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042281 Vd NA 0.5565 L/kg 1compartment NA NA Human Human DTXSID1042281 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1042281 TK.Half.Life NA 11.56 hours 1compartment NA NA Human Human -DTXSID1042281 Css NA 2.66 mg/L 3compartmentss NA 50% Human Human -DTXSID1042281 Css NA 10.09 mg/L 3compartmentss NA 95% Human Human -DTXSID1042281 Css NA 1.866 mg/L PBTK NA 50% Human Human -DTXSID1042281 Css NA 6.334 mg/L PBTK NA 95% Human Human -DTXSID1042281 Clint NA 0.1758 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042281 Fup NA 0.214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042281 Vd NA 0.4931 L/kg 1compartment NA NA Rat Human +DTXSID1042281 TK.Half.Life NA 12.04 hours 1compartment NA NA Human Human +DTXSID1042281 Css NA 2.352 mg/L 3compartmentss NA 50% Human Human +DTXSID1042281 Css NA 9.286 mg/L 3compartmentss NA 95% Human Human +DTXSID1042281 Css NA 1.73 mg/L PBTK NA 50% Human Human +DTXSID1042281 Css NA 5.925 mg/L PBTK NA 95% Human Human +DTXSID1042281 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042281 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042281 Vd NA 0.5597 L/kg 1compartment NA NA Rat Human DTXSID1042281 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1042281 TK.Half.Life NA 4.452 hours 1compartment NA NA Rat Human -DTXSID1042281 Css NA 0.8494 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042281 Css NA 2.762 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042281 Css NA 0.5666 mg/L PBTK NA 50% Rat Human -DTXSID1042281 Css NA 1.614 mg/L PBTK NA 95% Rat Human -DTXSID1042285 Clint NA 33.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042285 Fup NA 0.463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042285 Vd NA 1.422 L/kg 1compartment NA NA Human Human -DTXSID1042285 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1042285 TK.Half.Life NA 1.297 hours 1compartment NA NA Human Human -DTXSID1042285 Css NA 0.03094 mg/L 3compartmentss NA 50% Human Human -DTXSID1042285 Css NA 0.2524 mg/L 3compartmentss NA 95% Human Human -DTXSID1042285 Css NA 0.02522 mg/L PBTK NA 50% Human Human -DTXSID1042285 Css NA 0.178 mg/L PBTK NA 95% Human Human -DTXSID1042285 Clint NA 33.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042285 Fup NA 0.463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042285 Vd NA 1.203 L/kg 1compartment NA NA Rat Human +DTXSID1042281 TK.Half.Life NA 4.128 hours 1compartment NA NA Rat Human +DTXSID1042281 Css NA 0.1499 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042281 Css NA 0.5149 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042281 Css NA 0.1088 mg/L PBTK NA 50% Rat Human +DTXSID1042281 Css NA 0.3175 mg/L PBTK NA 95% Rat Human +DTXSID1042285 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042285 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042285 Vd NA 0.9578 L/kg 1compartment NA NA Human Human +DTXSID1042285 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1042285 TK.Half.Life NA 19.26 hours 1compartment NA NA Human Human +DTXSID1042285 Css NA 2.111 mg/L 3compartmentss NA 50% Human Human +DTXSID1042285 Css NA 8.663 mg/L 3compartmentss NA 95% Human Human +DTXSID1042285 Css NA 1.602 mg/L PBTK NA 50% Human Human +DTXSID1042285 Css NA 5.681 mg/L PBTK NA 95% Human Human +DTXSID1042285 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042285 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042285 Vd NA 0.8419 L/kg 1compartment NA NA Rat Human DTXSID1042285 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1042285 TK.Half.Life NA 0.52 hours 1compartment NA NA Rat Human -DTXSID1042285 Css NA 0.01654 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042285 Css NA 0.1135 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042285 Css NA 0.01314 mg/L PBTK NA 50% Rat Human -DTXSID1042285 Css NA 0.07732 mg/L PBTK NA 95% Rat Human -DTXSID1042360 Clint NA 7.181 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042360 Fup NA 0.256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042360 Vd NA 1.473 L/kg 1compartment NA NA Human Human +DTXSID1042285 TK.Half.Life NA 5.484 hours 1compartment NA NA Rat Human +DTXSID1042285 Css NA 0.1361 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042285 Css NA 0.4644 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042285 Css NA 0.1022 mg/L PBTK NA 50% Rat Human +DTXSID1042285 Css NA 0.2909 mg/L PBTK NA 95% Rat Human +DTXSID1042360 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042360 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042360 Vd NA 1.178 L/kg 1compartment NA NA Human Human DTXSID1042360 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1042360 TK.Half.Life NA 4.368 hours 1compartment NA NA Human Human -DTXSID1042360 Css NA 0.2783 mg/L 3compartmentss NA 50% Human Human -DTXSID1042360 Css NA 1.621 mg/L 3compartmentss NA 95% Human Human -DTXSID1042360 Css NA 0.2057 mg/L PBTK NA 50% Human Human -DTXSID1042360 Css NA 1.101 mg/L PBTK NA 95% Human Human -DTXSID1042360 Clint NA 7.181 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042360 Fup NA 0.256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042360 Vd NA 1.182 L/kg 1compartment NA NA Rat Human +DTXSID1042360 TK.Half.Life NA 6.038 hours 1compartment NA NA Human Human +DTXSID1042360 Css NA 0.6382 mg/L 3compartmentss NA 50% Human Human +DTXSID1042360 Css NA 4.419 mg/L 3compartmentss NA 95% Human Human +DTXSID1042360 Css NA 0.4282 mg/L PBTK NA 50% Human Human +DTXSID1042360 Css NA 2.749 mg/L PBTK NA 95% Human Human +DTXSID1042360 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042360 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042360 Vd NA 0.9311 L/kg 1compartment NA NA Rat Human DTXSID1042360 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1042360 TK.Half.Life NA 1.773 hours 1compartment NA NA Rat Human -DTXSID1042360 Css NA 0.1432 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042360 Css NA 0.6061 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042360 Css NA 0.1018 mg/L PBTK NA 50% Rat Human -DTXSID1042360 Css NA 0.3883 mg/L PBTK NA 95% Rat Human -DTXSID1042364 Clint NA 0.004913 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042364 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042364 Vd NA 0.1825 L/kg 1compartment NA NA Human Human -DTXSID1042364 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID1042364 TK.Half.Life NA 45.57 hours 1compartment NA NA Human Human -DTXSID1042364 Css NA 43.28 mg/L 3compartmentss NA 50% Human Human -DTXSID1042364 Css NA 264.1 mg/L 3compartmentss NA 95% Human Human -DTXSID1042364 Css NA 25.24 mg/L PBTK NA 50% Human Human -DTXSID1042364 Css NA 153.8 mg/L PBTK NA 95% Human Human -DTXSID1042364 Clint NA 0.004913 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042364 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042364 Vd NA 0.1812 L/kg 1compartment NA NA Rat Human -DTXSID1042364 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1042364 TK.Half.Life NA 15.48 hours 1compartment NA NA Rat Human -DTXSID1042364 Css NA 12.32 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042364 Css NA 66.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042364 Css NA 6.736 mg/L PBTK NA 50% Rat Human -DTXSID1042364 Css NA 36.13 mg/L PBTK NA 95% Rat Human -DTXSID1042441 Clint NA 106.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042441 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042441 Vd NA 1.47 L/kg 1compartment NA NA Human Human -DTXSID1042441 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1042441 TK.Half.Life NA 4.435 hours 1compartment NA NA Human Human -DTXSID1042441 Css NA 0.3755 mg/L 3compartmentss NA 50% Human Human -DTXSID1042441 Css NA 3.5 mg/L 3compartmentss NA 95% Human Human -DTXSID1042441 Css NA 0.2338 mg/L PBTK NA 50% Human Human -DTXSID1042441 Css NA 2.103 mg/L PBTK NA 95% Human Human -DTXSID1042441 Clint NA 106.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042441 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042441 Vd NA 1.085 L/kg 1compartment NA NA Rat Human +DTXSID1042360 TK.Half.Life NA 2.58 hours 1compartment NA NA Rat Human +DTXSID1042360 Css NA 0.07628 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042360 Css NA 0.3765 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042360 Css NA 0.05058 mg/L PBTK NA 50% Rat Human +DTXSID1042360 Css NA 0.2287 mg/L PBTK NA 95% Rat Human +DTXSID1042364 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042364 Fup 0.235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042364 Vd NA 0.3919 L/kg 1compartment NA NA Human Human +DTXSID1042364 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1042364 TK.Half.Life NA 1.199 hours 1compartment NA NA Human Human +DTXSID1042364 Css NA 0.2908 mg/L 3compartmentss NA 50% Human Human +DTXSID1042364 Css NA 1.771 mg/L 3compartmentss NA 95% Human Human +DTXSID1042364 Css NA 0.1962 mg/L PBTK NA 50% Human Human +DTXSID1042364 Css NA 1.126 mg/L PBTK NA 95% Human Human +DTXSID1042364 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042364 Fup 0.235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042364 Vd NA 0.3961 L/kg 1compartment NA NA Rat Human +DTXSID1042364 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1042364 TK.Half.Life NA 0.7042 hours 1compartment NA NA Rat Human +DTXSID1042364 Css NA 0.03534 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042364 Css NA 0.1544 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042364 Css NA 0.0235 mg/L PBTK NA 50% Rat Human +DTXSID1042364 Css NA 0.09366 mg/L PBTK NA 95% Rat Human +DTXSID1042441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042441 Fup 0.0153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042441 Vd NA 1.366 L/kg 1compartment NA NA Human Human +DTXSID1042441 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1042441 TK.Half.Life NA 15.09 hours 1compartment NA NA Human Human +DTXSID1042441 Css NA 1.754 mg/L 3compartmentss NA 50% Human Human +DTXSID1042441 Css NA 16.13 mg/L 3compartmentss NA 95% Human Human +DTXSID1042441 Css NA 1.09 mg/L PBTK NA 50% Human Human +DTXSID1042441 Css NA 9.48 mg/L PBTK NA 95% Human Human +DTXSID1042441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042441 Fup 0.0153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042441 Vd NA 1.009 L/kg 1compartment NA NA Rat Human DTXSID1042441 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1042441 TK.Half.Life NA 1.665 hours 1compartment NA NA Rat Human -DTXSID1042441 Css NA 0.2136 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042441 Css NA 1.688 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042441 Css NA 0.1245 mg/L PBTK NA 50% Rat Human -DTXSID1042441 Css NA 0.9527 mg/L PBTK NA 95% Rat Human -DTXSID1042443 Clint NA 29.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042443 Fup NA 0.1016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042443 Vd NA 1.212 L/kg 1compartment NA NA Human Human +DTXSID1042441 TK.Half.Life NA 6.017 hours 1compartment NA NA Rat Human +DTXSID1042441 Css NA 0.2278 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042441 Css NA 1.674 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042441 Css NA 0.1367 mg/L PBTK NA 50% Rat Human +DTXSID1042441 Css NA 0.9728 mg/L PBTK NA 95% Rat Human +DTXSID1042443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042443 Fup 0.0952 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042443 Vd NA 1.173 L/kg 1compartment NA NA Human Human DTXSID1042443 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1042443 TK.Half.Life NA 2.666 hours 1compartment NA NA Human Human -DTXSID1042443 Css NA 0.2232 mg/L 3compartmentss NA 50% Human Human -DTXSID1042443 Css NA 1.721 mg/L 3compartmentss NA 95% Human Human -DTXSID1042443 Css NA 0.1458 mg/L PBTK NA 50% Human Human -DTXSID1042443 Css NA 1.062 mg/L PBTK NA 95% Human Human -DTXSID1042443 Clint NA 29.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042443 Fup NA 0.1016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042443 Vd NA 0.9403 L/kg 1compartment NA NA Rat Human +DTXSID1042443 TK.Half.Life NA 3.259 hours 1compartment NA NA Human Human +DTXSID1042443 Css NA 0.305 mg/L 3compartmentss NA 50% Human Human +DTXSID1042443 Css NA 2.4 mg/L 3compartmentss NA 95% Human Human +DTXSID1042443 Css NA 0.1988 mg/L PBTK NA 50% Human Human +DTXSID1042443 Css NA 1.501 mg/L PBTK NA 95% Human Human +DTXSID1042443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042443 Fup 0.0952 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042443 Vd NA 0.9093 L/kg 1compartment NA NA Rat Human DTXSID1042443 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1042443 TK.Half.Life NA 1.094 hours 1compartment NA NA Rat Human -DTXSID1042443 Css NA 0.1226 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042443 Css NA 0.7506 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042443 Css NA 0.07587 mg/L PBTK NA 50% Rat Human -DTXSID1042443 Css NA 0.442 mg/L PBTK NA 95% Rat Human -DTXSID1042445 Clint NA 58.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042445 Fup NA 0.1049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042445 Vd NA 2.072 L/kg 1compartment NA NA Human Human +DTXSID1042443 TK.Half.Life NA 1.369 hours 1compartment NA NA Rat Human +DTXSID1042443 Css NA 0.03979 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042443 Css NA 0.2355 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042443 Css NA 0.02527 mg/L PBTK NA 50% Rat Human +DTXSID1042443 Css NA 0.1432 mg/L PBTK NA 95% Rat Human +DTXSID1042445 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042445 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042445 Vd NA 2.123 L/kg 1compartment NA NA Human Human DTXSID1042445 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1042445 TK.Half.Life NA 3.621 hours 1compartment NA NA Human Human -DTXSID1042445 Css NA 0.138 mg/L 3compartmentss NA 50% Human Human -DTXSID1042445 Css NA 1.008 mg/L 3compartmentss NA 95% Human Human -DTXSID1042445 Css NA 0.09366 mg/L PBTK NA 50% Human Human -DTXSID1042445 Css NA 0.6446 mg/L PBTK NA 95% Human Human -DTXSID1042445 Clint NA 58.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042445 Fup NA 0.1049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042445 Vd NA 1.57 L/kg 1compartment NA NA Rat Human +DTXSID1042445 TK.Half.Life NA 6.802 hours 1compartment NA NA Human Human +DTXSID1042445 Css NA 0.3369 mg/L 3compartmentss NA 50% Human Human +DTXSID1042445 Css NA 2.443 mg/L 3compartmentss NA 95% Human Human +DTXSID1042445 Css NA 0.2302 mg/L PBTK NA 50% Human Human +DTXSID1042445 Css NA 1.588 mg/L PBTK NA 95% Human Human +DTXSID1042445 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042445 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042445 Vd NA 1.609 L/kg 1compartment NA NA Rat Human DTXSID1042445 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1042445 TK.Half.Life NA 1.187 hours 1compartment NA NA Rat Human -DTXSID1042445 Css NA 0.07772 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042445 Css NA 0.459 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042445 Css NA 0.05031 mg/L PBTK NA 50% Rat Human -DTXSID1042445 Css NA 0.2818 mg/L PBTK NA 95% Rat Human -DTXSID1042499 Clint NA 15.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042499 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042499 Vd NA 48.51 L/kg 1compartment NA NA Human Human -DTXSID1042499 Days.Css NA 514 Days PBTK NA NA Human Human -DTXSID1042499 TK.Half.Life NA 1998 hours 1compartment NA NA Human Human -DTXSID1042499 Css NA 0.6394 mg/L 3compartmentss NA 50% Human Human -DTXSID1042499 Css NA 3.856 mg/L 3compartmentss NA 95% Human Human -DTXSID1042499 Css NA 3.422 mg/L PBTK NA 50% Human Human -DTXSID1042499 Css NA 19.18 mg/L PBTK NA 95% Human Human -DTXSID1042499 Clint NA 15.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042499 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042499 Vd NA 40.85 L/kg 1compartment NA NA Rat Human -DTXSID1042499 Days.Css NA 315 Days PBTK NA NA Rat Human -DTXSID1042499 TK.Half.Life NA 294.2 hours 1compartment NA NA Rat Human -DTXSID1042499 Css NA 0.3286 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042499 Css NA 1.424 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042499 Css NA 1.836 mg/L PBTK NA 50% Rat Human -DTXSID1042499 Css NA 7.815 mg/L PBTK NA 95% Rat Human -DTXSID1042570 Clint NA 101.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042570 Fup NA 0.0167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1042570 Vd NA 3.032 L/kg 1compartment NA NA Human Human +DTXSID1042445 TK.Half.Life NA 2.163 hours 1compartment NA NA Rat Human +DTXSID1042445 Css NA 0.04349 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042445 Css NA 0.2384 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042445 Css NA 0.02935 mg/L PBTK NA 50% Rat Human +DTXSID1042445 Css NA 0.1533 mg/L PBTK NA 95% Rat Human +DTXSID1042570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042570 Fup 0.0382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1042570 Vd NA 2.177 L/kg 1compartment NA NA Human Human DTXSID1042570 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1042570 TK.Half.Life NA 9.64 hours 1compartment NA NA Human Human -DTXSID1042570 Css NA 0.3138 mg/L 3compartmentss NA 50% Human Human -DTXSID1042570 Css NA 2.126 mg/L 3compartmentss NA 95% Human Human -DTXSID1042570 Css NA 0.2173 mg/L PBTK NA 50% Human Human -DTXSID1042570 Css NA 1.399 mg/L PBTK NA 95% Human Human -DTXSID1042570 Clint NA 101.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042570 Fup NA 0.0167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1042570 Vd NA 2.286 L/kg 1compartment NA NA Rat Human +DTXSID1042570 TK.Half.Life NA 11.47 hours 1compartment NA NA Human Human +DTXSID1042570 Css NA 0.6989 mg/L 3compartmentss NA 50% Human Human +DTXSID1042570 Css NA 5.831 mg/L 3compartmentss NA 95% Human Human +DTXSID1042570 Css NA 0.4736 mg/L PBTK NA 50% Human Human +DTXSID1042570 Css NA 3.68 mg/L PBTK NA 95% Human Human +DTXSID1042570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042570 Fup 0.0382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1042570 Vd NA 1.729 L/kg 1compartment NA NA Rat Human DTXSID1042570 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1042570 TK.Half.Life NA 1.935 hours 1compartment NA NA Rat Human -DTXSID1042570 Css NA 0.1761 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042570 Css NA 0.9451 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042570 Css NA 0.1165 mg/L PBTK NA 50% Rat Human -DTXSID1042570 Css NA 0.5964 mg/L PBTK NA 95% Rat Human +DTXSID1042570 TK.Half.Life NA 4.158 hours 1compartment NA NA Rat Human +DTXSID1042570 Css NA 0.08941 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042570 Css NA 0.591 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042570 Css NA 0.05951 mg/L PBTK NA 50% Rat Human +DTXSID1042570 Css NA 0.376 mg/L PBTK NA 95% Rat Human DTXSID1042574 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.30.12.1446 NA Human Human DTXSID1042574 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1042574 Vd NA 3.265 L/kg 1compartment NA NA Human Human DTXSID1042574 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID1042574 TK.Half.Life NA 21.13 hours 1compartment NA NA Human Human -DTXSID1042574 Css NA 0.2237 mg/L 3compartmentss NA 50% Human Human -DTXSID1042574 Css NA 1.578 mg/L 3compartmentss NA 95% Human Human -DTXSID1042574 Css NA 0.2027 mg/L PBTK NA 50% Human Human -DTXSID1042574 Css NA 1.043 mg/L PBTK NA 95% Human Human +DTXSID1042574 Css NA 0.3248 mg/L 3compartmentss NA 50% Human Human +DTXSID1042574 Css NA 1.747 mg/L 3compartmentss NA 95% Human Human +DTXSID1042574 Css NA 0.3247 mg/L PBTK NA 50% Human Human +DTXSID1042574 Css NA 1.747 mg/L PBTK NA 95% Human Human DTXSID1042574 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.30.12.1446 NA Rat Human DTXSID1042574 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1042574 Vd NA 3.323 L/kg 1compartment NA NA Rat Human DTXSID1042574 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1042574 TK.Half.Life NA 7.329 hours 1compartment NA NA Rat Human -DTXSID1042574 Css NA 0.1926 mg/L 3compartmentss NA 50% Rat Human -DTXSID1042574 Css NA 1.298 mg/L 3compartmentss NA 95% Rat Human -DTXSID1042574 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID1042574 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID1042574 Css NA 0.001436 mg/L 3compartmentss NA 50% Rat Human +DTXSID1042574 Css NA 0.007071 mg/L 3compartmentss NA 95% Rat Human +DTXSID1042574 Css NA 0.00144 mg/L PBTK NA 50% Rat Human +DTXSID1042574 Css NA 0.007099 mg/L PBTK NA 95% Rat Human DTXSID1043835 Clint 4.283 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1043835 Fup 0.19 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1043835 Vd NA 1.81 L/kg 1compartment NA NA Human Human DTXSID1043835 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1043835 TK.Half.Life NA 8.007 hours 1compartment NA NA Human Human -DTXSID1043835 Css NA 0.3945 mg/L 3compartmentss NA 50% Human Human -DTXSID1043835 Css NA 2.385 mg/L 3compartmentss NA 95% Human Human -DTXSID1043835 Css NA 0.3374 mg/L PBTK NA 50% Human Human -DTXSID1043835 Css NA 1.735 mg/L PBTK NA 95% Human Human +DTXSID1043835 Css NA 0.3822 mg/L 3compartmentss NA 50% Human Human +DTXSID1043835 Css NA 2.422 mg/L 3compartmentss NA 95% Human Human +DTXSID1043835 Css NA 0.3284 mg/L PBTK NA 50% Human Human +DTXSID1043835 Css NA 1.774 mg/L PBTK NA 95% Human Human DTXSID1043835 Clint 4.283 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID1043835 Fup 0.19 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1043835 Vd NA 1.806 L/kg 1compartment NA NA Rat Human DTXSID1043835 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1043835 TK.Half.Life NA 4.744 hours 1compartment NA NA Rat Human -DTXSID1043835 Css NA 0.1933 mg/L 3compartmentss NA 50% Rat Human -DTXSID1043835 Css NA 0.8677 mg/L 3compartmentss NA 95% Rat Human -DTXSID1043835 Css NA 0.1625 mg/L PBTK NA 50% Rat Human -DTXSID1043835 Css NA 0.5894 mg/L PBTK NA 95% Rat Human -DTXSID1043839 Clint NA 12.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1043835 Css NA 0.04308 mg/L 3compartmentss NA 50% Rat Human +DTXSID1043835 Css NA 0.2002 mg/L 3compartmentss NA 95% Rat Human +DTXSID1043835 Css NA 0.03747 mg/L PBTK NA 50% Rat Human +DTXSID1043835 Css NA 0.142 mg/L PBTK NA 95% Rat Human +DTXSID1043839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1043839 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1043839 Vd NA 3.232 L/kg 1compartment NA NA Human Human -DTXSID1043839 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1043839 TK.Half.Life NA 17.89 hours 1compartment NA NA Human Human -DTXSID1043839 Css NA 0.5828 mg/L 3compartmentss NA 50% Human Human -DTXSID1043839 Css NA 3.764 mg/L 3compartmentss NA 95% Human Human -DTXSID1043839 Css NA 0.4499 mg/L PBTK NA 50% Human Human -DTXSID1043839 Css NA 2.722 mg/L PBTK NA 95% Human Human -DTXSID1043839 Clint NA 12.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1043839 Vd NA 3.155 L/kg 1compartment NA NA Human Human +DTXSID1043839 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1043839 TK.Half.Life NA 9.258 hours 1compartment NA NA Human Human +DTXSID1043839 Css NA 0.2609 mg/L 3compartmentss NA 50% Human Human +DTXSID1043839 Css NA 1.872 mg/L 3compartmentss NA 95% Human Human +DTXSID1043839 Css NA 0.2054 mg/L PBTK NA 50% Human Human +DTXSID1043839 Css NA 1.327 mg/L PBTK NA 95% Human Human +DTXSID1043839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1043839 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1043839 Vd NA 2.609 L/kg 1compartment NA NA Rat Human +DTXSID1043839 Vd NA 2.6 L/kg 1compartment NA NA Rat Human DTXSID1043839 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1043839 TK.Half.Life NA 4.263 hours 1compartment NA NA Rat Human -DTXSID1043839 Css NA 0.3178 mg/L 3compartmentss NA 50% Rat Human -DTXSID1043839 Css NA 1.578 mg/L 3compartmentss NA 95% Rat Human -DTXSID1043839 Css NA 0.2363 mg/L PBTK NA 50% Rat Human -DTXSID1043839 Css NA 1.11 mg/L PBTK NA 95% Rat Human +DTXSID1043839 TK.Half.Life NA 2.691 hours 1compartment NA NA Rat Human +DTXSID1043839 Css NA 0.03362 mg/L 3compartmentss NA 50% Rat Human +DTXSID1043839 Css NA 0.1883 mg/L 3compartmentss NA 95% Rat Human +DTXSID1043839 Css NA 0.02634 mg/L PBTK NA 50% Rat Human +DTXSID1043839 Css NA 0.1398 mg/L PBTK NA 95% Rat Human DTXSID1043881 Clint 35.05 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1043881 Fup 0.1 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID1043881 Vd NA 3.46 L/kg 1compartment NA NA Human Human DTXSID1043881 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1043881 TK.Half.Life NA 10.82 hours 1compartment NA NA Human Human -DTXSID1043881 Css NA 0.3808 mg/L 3compartmentss NA 50% Human Human -DTXSID1043881 Css NA 2.294 mg/L 3compartmentss NA 95% Human Human -DTXSID1043881 Css NA 0.236 mg/L PBTK NA 50% Human Human -DTXSID1043881 Css NA 1.389 mg/L PBTK NA 95% Human Human +DTXSID1043881 Css NA 0.2089 mg/L 3compartmentss NA 50% Human Human +DTXSID1043881 Css NA 1.397 mg/L 3compartmentss NA 95% Human Human +DTXSID1043881 Css NA 0.2235 mg/L PBTK NA 50% Human Human +DTXSID1043881 Css NA 1.495 mg/L PBTK NA 95% Human Human DTXSID1043881 Clint 35.05 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID1043881 Fup 0.1 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human -DTXSID1043881 Vd NA 2.859 L/kg 1compartment NA NA Rat Human +DTXSID1043881 Vd 6.2 2.859 L/kg 1compartment Wambaugh et al. (2018) NA Rat Human DTXSID1043881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1043881 TK.Half.Life NA 1.734 hours 1compartment NA NA Rat Human -DTXSID1043881 Css NA 0.2072 mg/L 3compartmentss NA 50% Rat Human -DTXSID1043881 Css NA 1.036 mg/L 3compartmentss NA 95% Rat Human -DTXSID1043881 Css NA 0.1158 mg/L PBTK NA 50% Rat Human -DTXSID1043881 Css NA 0.5794 mg/L PBTK NA 95% Rat Human -DTXSID1043910 Clint NA 62.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1043910 Fup NA 0.1579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1043910 Vd NA 1.644 L/kg 1compartment NA NA Human Human +DTXSID1043881 TK.Half.Life 0.37 1.734 hours 1compartment Wambaugh et al. (2018) NA Rat Human +DTXSID1043881 Css 0.0036 0.02409 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Human +DTXSID1043881 Css 0.0036 0.1271 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Human +DTXSID1043881 Css 0.0036 0.0267 mg/L PBTK Wambaugh et al. (2018) 50% Rat Human +DTXSID1043881 Css 0.0036 0.1408 mg/L PBTK Wambaugh et al. (2018) 95% Rat Human +DTXSID1043910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1043910 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1043910 Vd NA 2.62 L/kg 1compartment NA NA Human Human DTXSID1043910 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1043910 TK.Half.Life NA 2.099 hours 1compartment NA NA Human Human -DTXSID1043910 Css NA 0.0682 mg/L 3compartmentss NA 50% Human Human -DTXSID1043910 Css NA 0.5038 mg/L 3compartmentss NA 95% Human Human -DTXSID1043910 Css NA 0.0476 mg/L PBTK NA 50% Human Human -DTXSID1043910 Css NA 0.3283 mg/L PBTK NA 95% Human Human -DTXSID1043910 Clint NA 62.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1043910 Fup NA 0.1579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1043910 Vd NA 1.274 L/kg 1compartment NA NA Rat Human +DTXSID1043910 TK.Half.Life NA 7.801 hours 1compartment NA NA Human Human +DTXSID1043910 Css NA 0.2629 mg/L 3compartmentss NA 50% Human Human +DTXSID1043910 Css NA 1.654 mg/L 3compartmentss NA 95% Human Human +DTXSID1043910 Css NA 0.1899 mg/L PBTK NA 50% Human Human +DTXSID1043910 Css NA 1.149 mg/L PBTK NA 95% Human Human +DTXSID1043910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1043910 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1043910 Vd NA 1.991 L/kg 1compartment NA NA Rat Human DTXSID1043910 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1043910 TK.Half.Life NA 0.7606 hours 1compartment NA NA Rat Human -DTXSID1043910 Css NA 0.03825 mg/L 3compartmentss NA 50% Rat Human -DTXSID1043910 Css NA 0.2351 mg/L 3compartmentss NA 95% Rat Human -DTXSID1043910 Css NA 0.02534 mg/L PBTK NA 50% Rat Human -DTXSID1043910 Css NA 0.144 mg/L PBTK NA 95% Rat Human -DTXSID1044196 Clint NA 3.572 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044196 Fup NA 0.1144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044196 Vd NA 3.107 L/kg 1compartment NA NA Human Human -DTXSID1044196 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1044196 TK.Half.Life NA 37.21 hours 1compartment NA NA Human Human -DTXSID1044196 Css NA 1.406 mg/L 3compartmentss NA 50% Human Human -DTXSID1044196 Css NA 7.773 mg/L 3compartmentss NA 95% Human Human -DTXSID1044196 Css NA 1.118 mg/L PBTK NA 50% Human Human -DTXSID1044196 Css NA 5.491 mg/L PBTK NA 95% Human Human -DTXSID1044196 Clint NA 3.572 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044196 Fup NA 0.1144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044196 Vd NA 2.614 L/kg 1compartment NA NA Rat Human -DTXSID1044196 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1044196 TK.Half.Life NA 11.05 hours 1compartment NA NA Rat Human -DTXSID1044196 Css NA 0.7108 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044196 Css NA 2.925 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044196 Css NA 0.5466 mg/L PBTK NA 50% Rat Human -DTXSID1044196 Css NA 1.968 mg/L PBTK NA 95% Rat Human -DTXSID1044198 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044198 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044198 Vd NA 0.7236 L/kg 1compartment NA NA Human Human -DTXSID1044198 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1044198 TK.Half.Life NA 14.28 hours 1compartment NA NA Human Human -DTXSID1044198 Css NA 2.232 mg/L 3compartmentss NA 50% Human Human -DTXSID1044198 Css NA 9.34 mg/L 3compartmentss NA 95% Human Human -DTXSID1044198 Css NA 1.619 mg/L PBTK NA 50% Human Human -DTXSID1044198 Css NA 5.891 mg/L PBTK NA 95% Human Human -DTXSID1044198 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044198 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044198 Vd NA 0.7279 L/kg 1compartment NA NA Rat Human +DTXSID1043910 TK.Half.Life NA 2.01 hours 1compartment NA NA Rat Human +DTXSID1043910 Css NA 0.03298 mg/L 3compartmentss NA 50% Rat Human +DTXSID1043910 Css NA 0.1639 mg/L 3compartmentss NA 95% Rat Human +DTXSID1043910 Css NA 0.02376 mg/L PBTK NA 50% Rat Human +DTXSID1043910 Css NA 0.1127 mg/L PBTK NA 95% Rat Human +DTXSID1044196 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044196 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044196 Vd NA 2.741 L/kg 1compartment NA NA Human Human +DTXSID1044196 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1044196 TK.Half.Life NA 12.95 hours 1compartment NA NA Human Human +DTXSID1044196 Css NA 0.4682 mg/L 3compartmentss NA 50% Human Human +DTXSID1044196 Css NA 3.489 mg/L 3compartmentss NA 95% Human Human +DTXSID1044196 Css NA 0.3936 mg/L PBTK NA 50% Human Human +DTXSID1044196 Css NA 2.509 mg/L PBTK NA 95% Human Human +DTXSID1044196 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044196 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044196 Vd NA 2.481 L/kg 1compartment NA NA Rat Human +DTXSID1044196 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1044196 TK.Half.Life NA 5.796 hours 1compartment NA NA Rat Human +DTXSID1044196 Css NA 0.05674 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044196 Css NA 0.3043 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044196 Css NA 0.04764 mg/L PBTK NA 50% Rat Human +DTXSID1044196 Css NA 0.2155 mg/L PBTK NA 95% Rat Human +DTXSID1044198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044198 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044198 Vd NA 2.638 L/kg 1compartment NA NA Human Human +DTXSID1044198 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1044198 TK.Half.Life NA 3.022 hours 1compartment NA NA Human Human +DTXSID1044198 Css NA 0.04546 mg/L 3compartmentss NA 50% Human Human +DTXSID1044198 Css NA 0.3704 mg/L 3compartmentss NA 95% Human Human +DTXSID1044198 Css NA 0.04202 mg/L PBTK NA 50% Human Human +DTXSID1044198 Css NA 0.2959 mg/L PBTK NA 95% Human Human +DTXSID1044198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044198 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044198 Vd NA 2.382 L/kg 1compartment NA NA Rat Human DTXSID1044198 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044198 TK.Half.Life NA 4.895 hours 1compartment NA NA Rat Human -DTXSID1044198 Css NA 0.6201 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044198 Css NA 2.151 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044198 Css NA 0.4274 mg/L PBTK NA 50% Rat Human -DTXSID1044198 Css NA 1.27 mg/L PBTK NA 95% Rat Human -DTXSID1044221 Clint NA 2550 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044221 Fup NA 0.058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044221 Vd NA 2.099 L/kg 1compartment NA NA Human Human +DTXSID1044198 TK.Half.Life NA 1.299 hours 1compartment NA NA Rat Human +DTXSID1044198 Css NA 0.002108 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044198 Css NA 0.01885 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044198 Css NA 0.001986 mg/L PBTK NA 50% Rat Human +DTXSID1044198 Css NA 0.01494 mg/L PBTK NA 95% Rat Human +DTXSID1044221 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044221 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044221 Vd NA 0.2692 L/kg 1compartment NA NA Human Human DTXSID1044221 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044221 TK.Half.Life NA 1.851 hours 1compartment NA NA Human Human -DTXSID1044221 Css NA 0.005673 mg/L 3compartmentss NA 50% Human Human -DTXSID1044221 Css NA 0.04493 mg/L 3compartmentss NA 95% Human Human -DTXSID1044221 Css NA 0.00376 mg/L PBTK NA 50% Human Human -DTXSID1044221 Css NA 0.02897 mg/L PBTK NA 95% Human Human -DTXSID1044221 Clint NA 2550 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044221 Fup NA 0.058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044221 Vd NA 1.574 L/kg 1compartment NA NA Rat Human +DTXSID1044221 TK.Half.Life NA 0.6022 hours 1compartment NA NA Human Human +DTXSID1044221 Css NA 0.1722 mg/L 3compartmentss NA 50% Human Human +DTXSID1044221 Css NA 1.469 mg/L 3compartmentss NA 95% Human Human +DTXSID1044221 Css NA 0.1061 mg/L PBTK NA 50% Human Human +DTXSID1044221 Css NA 0.8759 mg/L PBTK NA 95% Human Human +DTXSID1044221 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044221 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044221 Vd NA 0.2753 L/kg 1compartment NA NA Rat Human DTXSID1044221 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044221 TK.Half.Life NA 0.6054 hours 1compartment NA NA Rat Human -DTXSID1044221 Css NA 0.003286 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044221 Css NA 0.02017 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044221 Css NA 0.002058 mg/L PBTK NA 50% Rat Human -DTXSID1044221 Css NA 0.01192 mg/L PBTK NA 95% Rat Human -DTXSID1044223 Clint NA 10.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044223 Fup NA 0.0186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044223 Vd NA 2.25 L/kg 1compartment NA NA Human Human -DTXSID1044223 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID1044223 TK.Half.Life NA 49.48 hours 1compartment NA NA Human Human -DTXSID1044223 Css NA 3.368 mg/L 3compartmentss NA 50% Human Human -DTXSID1044223 Css NA 25.45 mg/L 3compartmentss NA 95% Human Human -DTXSID1044223 Css NA 2.202 mg/L PBTK NA 50% Human Human -DTXSID1044223 Css NA 15.63 mg/L PBTK NA 95% Human Human -DTXSID1044223 Clint NA 10.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044223 Fup NA 0.0186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044223 Vd NA 1.674 L/kg 1compartment NA NA Rat Human -DTXSID1044223 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID1044223 TK.Half.Life NA 13.88 hours 1compartment NA NA Rat Human -DTXSID1044223 Css NA 1.845 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044223 Css NA 11.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044223 Css NA 1.138 mg/L PBTK NA 50% Rat Human -DTXSID1044223 Css NA 6.556 mg/L PBTK NA 95% Rat Human -DTXSID1044227 Clint NA 6.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044227 Fup NA 0.6635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044227 Vd NA 4.538 L/kg 1compartment NA NA Human Human -DTXSID1044227 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044227 TK.Half.Life NA 5.012 hours 1compartment NA NA Human Human -DTXSID1044227 Css NA 0.05732 mg/L 3compartmentss NA 50% Human Human -DTXSID1044227 Css NA 0.6964 mg/L 3compartmentss NA 95% Human Human -DTXSID1044227 Css NA 0.08271 mg/L PBTK NA 50% Human Human -DTXSID1044227 Css NA 0.6419 mg/L PBTK NA 95% Human Human -DTXSID1044227 Clint NA 6.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044227 Fup NA 0.6635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044227 Vd NA 4.638 L/kg 1compartment NA NA Rat Human -DTXSID1044227 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044227 TK.Half.Life NA 2.917 hours 1compartment NA NA Rat Human -DTXSID1044227 Css NA 0.02702 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044227 Css NA 0.2849 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044227 Css NA 0.03976 mg/L PBTK NA 50% Rat Human -DTXSID1044227 Css NA 0.2286 mg/L PBTK NA 95% Rat Human -DTXSID1044356 Clint NA 10.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044356 Fup NA 0.9645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044356 Vd NA 3.089 L/kg 1compartment NA NA Human Human -DTXSID1044356 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044356 TK.Half.Life NA 2.17 hours 1compartment NA NA Human Human -DTXSID1044356 Css NA 0.03626 mg/L 3compartmentss NA 50% Human Human -DTXSID1044356 Css NA 0.3348 mg/L 3compartmentss NA 95% Human Human -DTXSID1044356 Css NA 0.04122 mg/L PBTK NA 50% Human Human -DTXSID1044356 Css NA 0.2979 mg/L PBTK NA 95% Human Human -DTXSID1044356 Clint NA 10.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044356 Fup NA 0.9645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044356 Vd NA 3.144 L/kg 1compartment NA NA Rat Human +DTXSID1044221 TK.Half.Life NA 0.3566 hours 1compartment NA NA Rat Human +DTXSID1044221 Css NA 0.004032 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044221 Css NA 0.04176 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044221 Css NA 0.002337 mg/L PBTK NA 50% Rat Human +DTXSID1044221 Css NA 0.02411 mg/L PBTK NA 95% Rat Human +DTXSID1044223 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044223 Fup 0.0524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044223 Vd NA 2.991 L/kg 1compartment NA NA Human Human +DTXSID1044223 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1044223 TK.Half.Life NA 40.3 hours 1compartment NA NA Human Human +DTXSID1044223 Css NA 1.586 mg/L 3compartmentss NA 50% Human Human +DTXSID1044223 Css NA 10.54 mg/L 3compartmentss NA 95% Human Human +DTXSID1044223 Css NA 1.098 mg/L PBTK NA 50% Human Human +DTXSID1044223 Css NA 7.09 mg/L PBTK NA 95% Human Human +DTXSID1044223 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044223 Fup 0.0524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044223 Vd NA 2.242 L/kg 1compartment NA NA Rat Human +DTXSID1044223 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1044223 TK.Half.Life NA 6.646 hours 1compartment NA NA Rat Human +DTXSID1044223 Css NA 0.2062 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044223 Css NA 1.164 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044223 Css NA 0.141 mg/L PBTK NA 50% Rat Human +DTXSID1044223 Css NA 0.7803 mg/L PBTK NA 95% Rat Human +DTXSID1044227 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044227 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044227 Vd NA 3.383 L/kg 1compartment NA NA Human Human +DTXSID1044227 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1044227 TK.Half.Life NA 36.18 hours 1compartment NA NA Human Human +DTXSID1044227 Css NA 0.7524 mg/L 3compartmentss NA 50% Human Human +DTXSID1044227 Css NA 7.109 mg/L 3compartmentss NA 95% Human Human +DTXSID1044227 Css NA 0.9478 mg/L PBTK NA 50% Human Human +DTXSID1044227 Css NA 5.239 mg/L PBTK NA 95% Human Human +DTXSID1044227 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044227 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044227 Vd NA 3.439 L/kg 1compartment NA NA Rat Human +DTXSID1044227 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1044227 TK.Half.Life NA 12.5 hours 1compartment NA NA Rat Human +DTXSID1044227 Css NA 0.0448 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044227 Css NA 0.3901 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044227 Css NA 0.05758 mg/L PBTK NA 50% Rat Human +DTXSID1044227 Css NA 0.2767 mg/L PBTK NA 95% Rat Human +DTXSID1044356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044356 Fup 0.595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044356 Vd NA 2.207 L/kg 1compartment NA NA Human Human +DTXSID1044356 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1044356 TK.Half.Life NA 24.17 hours 1compartment NA NA Human Human +DTXSID1044356 Css NA 0.9482 mg/L 3compartmentss NA 50% Human Human +DTXSID1044356 Css NA 7.675 mg/L 3compartmentss NA 95% Human Human +DTXSID1044356 Css NA 0.9702 mg/L PBTK NA 50% Human Human +DTXSID1044356 Css NA 5.195 mg/L PBTK NA 95% Human Human +DTXSID1044356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044356 Fup 0.595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044356 Vd NA 2.232 L/kg 1compartment NA NA Rat Human DTXSID1044356 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044356 TK.Half.Life NA 1.161 hours 1compartment NA NA Rat Human -DTXSID1044356 Css NA 0.01749 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044356 Css NA 0.1513 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044356 Css NA 0.02029 mg/L PBTK NA 50% Rat Human -DTXSID1044356 Css NA 0.124 mg/L PBTK NA 95% Rat Human -DTXSID1044431 Clint NA 0.01012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044431 Fup NA 0.8199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044431 Vd NA 1.989 L/kg 1compartment NA NA Human Human +DTXSID1044356 TK.Half.Life NA 8.286 hours 1compartment NA NA Rat Human +DTXSID1044356 Css NA 0.05581 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044356 Css NA 0.4313 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044356 Css NA 0.05816 mg/L PBTK NA 50% Rat Human +DTXSID1044356 Css NA 0.2842 mg/L PBTK NA 95% Rat Human +DTXSID1044431 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044431 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044431 Vd NA 1.759 L/kg 1compartment NA NA Human Human DTXSID1044431 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1044431 TK.Half.Life NA 15.43 hours 1compartment NA NA Human Human -DTXSID1044431 Css NA 0.7592 mg/L 3compartmentss NA 50% Human Human -DTXSID1044431 Css NA 5.252 mg/L 3compartmentss NA 95% Human Human -DTXSID1044431 Css NA 0.7836 mg/L PBTK NA 50% Human Human -DTXSID1044431 Css NA 3.711 mg/L PBTK NA 95% Human Human -DTXSID1044431 Clint NA 0.01012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044431 Fup NA 0.8199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044431 Vd NA 1.985 L/kg 1compartment NA NA Rat Human +DTXSID1044431 TK.Half.Life NA 16.59 hours 1compartment NA NA Human Human +DTXSID1044431 Css NA 0.7595 mg/L 3compartmentss NA 50% Human Human +DTXSID1044431 Css NA 5.6 mg/L 3compartmentss NA 95% Human Human +DTXSID1044431 Css NA 0.7575 mg/L PBTK NA 50% Human Human +DTXSID1044431 Css NA 3.842 mg/L PBTK NA 95% Human Human +DTXSID1044431 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044431 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044431 Vd NA 1.753 L/kg 1compartment NA NA Rat Human DTXSID1044431 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044431 TK.Half.Life NA 5.295 hours 1compartment NA NA Rat Human -DTXSID1044431 Css NA 0.1931 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044431 Css NA 1.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044431 Css NA 0.1982 mg/L PBTK NA 50% Rat Human -DTXSID1044431 Css NA 0.8942 mg/L PBTK NA 95% Rat Human -DTXSID1044433 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044433 Fup NA 0.5087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044433 Vd NA 0.4238 L/kg 1compartment NA NA Human Human +DTXSID1044431 TK.Half.Life NA 5.635 hours 1compartment NA NA Rat Human +DTXSID1044431 Css NA 0.01461 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044431 Css NA 0.135 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044431 Css NA 0.014 mg/L PBTK NA 50% Rat Human +DTXSID1044431 Css NA 0.09512 mg/L PBTK NA 95% Rat Human +DTXSID1044433 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044433 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044433 Vd NA 0.7655 L/kg 1compartment NA NA Human Human DTXSID1044433 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044433 TK.Half.Life NA 5.39 hours 1compartment NA NA Human Human -DTXSID1044433 Css NA 1.534 mg/L 3compartmentss NA 50% Human Human -DTXSID1044433 Css NA 7.884 mg/L 3compartmentss NA 95% Human Human -DTXSID1044433 Css NA 1.106 mg/L PBTK NA 50% Human Human -DTXSID1044433 Css NA 4.949 mg/L PBTK NA 95% Human Human -DTXSID1044433 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044433 Fup NA 0.5087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044433 Vd NA 0.435 L/kg 1compartment NA NA Rat Human +DTXSID1044433 TK.Half.Life NA 8.932 hours 1compartment NA NA Human Human +DTXSID1044433 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human +DTXSID1044433 Css NA 7.643 mg/L 3compartmentss NA 95% Human Human +DTXSID1044433 Css NA 0.894 mg/L PBTK NA 50% Human Human +DTXSID1044433 Css NA 4.852 mg/L PBTK NA 95% Human Human +DTXSID1044433 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044433 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044433 Vd NA 0.7521 L/kg 1compartment NA NA Rat Human DTXSID1044433 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044433 TK.Half.Life NA 1.886 hours 1compartment NA NA Rat Human -DTXSID1044433 Css NA 0.4126 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044433 Css NA 1.853 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044433 Css NA 0.2831 mg/L PBTK NA 50% Rat Human -DTXSID1044433 Css NA 1.072 mg/L PBTK NA 95% Rat Human -DTXSID1044435 Clint NA 76.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044435 Fup NA 0.4819 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044435 Vd NA 3.195 L/kg 1compartment NA NA Human Human +DTXSID1044433 TK.Half.Life NA 2.963 hours 1compartment NA NA Rat Human +DTXSID1044433 Css NA 0.02064 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044433 Css NA 0.195 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044433 Css NA 0.01616 mg/L PBTK NA 50% Rat Human +DTXSID1044433 Css NA 0.1197 mg/L PBTK NA 95% Rat Human +DTXSID1044435 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044435 Fup 0.648 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044435 Vd NA 1.937 L/kg 1compartment NA NA Human Human DTXSID1044435 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044435 TK.Half.Life NA 1.858 hours 1compartment NA NA Human Human -DTXSID1044435 Css NA 0.009303 mg/L 3compartmentss NA 50% Human Human -DTXSID1044435 Css NA 0.095 mg/L 3compartmentss NA 95% Human Human -DTXSID1044435 Css NA 0.01024 mg/L PBTK NA 50% Human Human -DTXSID1044435 Css NA 0.08055 mg/L PBTK NA 95% Human Human -DTXSID1044435 Clint NA 76.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044435 Fup NA 0.4819 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044435 Vd NA 3.117 L/kg 1compartment NA NA Rat Human +DTXSID1044435 TK.Half.Life NA 2.539 hours 1compartment NA NA Human Human +DTXSID1044435 Css NA 0.08656 mg/L 3compartmentss NA 50% Human Human +DTXSID1044435 Css NA 0.8738 mg/L 3compartmentss NA 95% Human Human +DTXSID1044435 Css NA 0.08352 mg/L PBTK NA 50% Human Human +DTXSID1044435 Css NA 0.6385 mg/L PBTK NA 95% Human Human +DTXSID1044435 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044435 Fup 0.648 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044435 Vd NA 1.958 L/kg 1compartment NA NA Rat Human DTXSID1044435 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044435 TK.Half.Life NA 0.8407 hours 1compartment NA NA Rat Human -DTXSID1044435 Css NA 0.004978 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044435 Css NA 0.04095 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044435 Css NA 0.005441 mg/L PBTK NA 50% Rat Human -DTXSID1044435 Css NA 0.03341 mg/L PBTK NA 95% Rat Human -DTXSID1044437 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044437 Fup NA 0.4354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044437 Vd NA 0.358 L/kg 1compartment NA NA Human Human +DTXSID1044435 TK.Half.Life NA 1.41 hours 1compartment NA NA Rat Human +DTXSID1044435 Css NA 0.009275 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044435 Css NA 0.0863 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044435 Css NA 0.009426 mg/L PBTK NA 50% Rat Human +DTXSID1044435 Css NA 0.05904 mg/L PBTK NA 95% Rat Human +DTXSID1044437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044437 Fup 0.533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044437 Vd NA 0.4557 L/kg 1compartment NA NA Human Human DTXSID1044437 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044437 TK.Half.Life NA 5.32 hours 1compartment NA NA Human Human -DTXSID1044437 Css NA 1.789 mg/L 3compartmentss NA 50% Human Human -DTXSID1044437 Css NA 7.765 mg/L 3compartmentss NA 95% Human Human -DTXSID1044437 Css NA 1.232 mg/L PBTK NA 50% Human Human -DTXSID1044437 Css NA 4.801 mg/L PBTK NA 95% Human Human -DTXSID1044437 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044437 Fup NA 0.4354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044437 Vd NA 0.3683 L/kg 1compartment NA NA Rat Human +DTXSID1044437 TK.Half.Life NA 5.532 hours 1compartment NA NA Human Human +DTXSID1044437 Css NA 0.7808 mg/L 3compartmentss NA 50% Human Human +DTXSID1044437 Css NA 4.681 mg/L 3compartmentss NA 95% Human Human +DTXSID1044437 Css NA 0.5797 mg/L PBTK NA 50% Human Human +DTXSID1044437 Css NA 2.946 mg/L PBTK NA 95% Human Human +DTXSID1044437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044437 Fup 0.533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044437 Vd NA 0.4704 L/kg 1compartment NA NA Rat Human DTXSID1044437 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044437 TK.Half.Life NA 1.865 hours 1compartment NA NA Rat Human -DTXSID1044437 Css NA 0.504 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044437 Css NA 1.824 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044437 Css NA 0.3276 mg/L PBTK NA 50% Rat Human -DTXSID1044437 Css NA 1.048 mg/L PBTK NA 95% Rat Human -DTXSID1044439 Clint NA 0.1232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044439 Fup NA 0.4387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044439 Vd NA 0.3788 L/kg 1compartment NA NA Human Human +DTXSID1044437 TK.Half.Life NA 1.945 hours 1compartment NA NA Rat Human +DTXSID1044437 Css NA 0.004131 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044437 Css NA 0.02529 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044437 Css NA 0.002924 mg/L PBTK NA 50% Rat Human +DTXSID1044437 Css NA 0.01487 mg/L PBTK NA 95% Rat Human +DTXSID1044439 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044439 Fup 0.69 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044439 Vd NA 0.9867 L/kg 1compartment NA NA Human Human DTXSID1044439 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044439 TK.Half.Life NA 4.646 hours 1compartment NA NA Human Human -DTXSID1044439 Css NA 1.446 mg/L 3compartmentss NA 50% Human Human -DTXSID1044439 Css NA 6.562 mg/L 3compartmentss NA 95% Human Human -DTXSID1044439 Css NA 1.001 mg/L PBTK NA 50% Human Human -DTXSID1044439 Css NA 4.03 mg/L PBTK NA 95% Human Human -DTXSID1044439 Clint NA 0.1232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044439 Fup NA 0.4387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044439 Vd NA 0.3867 L/kg 1compartment NA NA Rat Human +DTXSID1044439 TK.Half.Life NA 9.533 hours 1compartment NA NA Human Human +DTXSID1044439 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human +DTXSID1044439 Css NA 6.935 mg/L 3compartmentss NA 95% Human Human +DTXSID1044439 Css NA 0.8799 mg/L PBTK NA 50% Human Human +DTXSID1044439 Css NA 4.454 mg/L PBTK NA 95% Human Human +DTXSID1044439 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044439 Fup 0.69 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044439 Vd NA 0.9437 L/kg 1compartment NA NA Rat Human DTXSID1044439 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044439 TK.Half.Life NA 1.769 hours 1compartment NA NA Rat Human -DTXSID1044439 Css NA 0.4438 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044439 Css NA 1.759 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044439 Css NA 0.2915 mg/L PBTK NA 50% Rat Human -DTXSID1044439 Css NA 1.01 mg/L PBTK NA 95% Rat Human -DTXSID1044481 Clint NA 6.271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044481 Fup NA 0.3353 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044481 Vd NA 1.142 L/kg 1compartment NA NA Human Human -DTXSID1044481 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044481 TK.Half.Life NA 2.764 hours 1compartment NA NA Human Human -DTXSID1044481 Css NA 0.2114 mg/L 3compartmentss NA 50% Human Human -DTXSID1044481 Css NA 1.305 mg/L 3compartmentss NA 95% Human Human -DTXSID1044481 Css NA 0.1609 mg/L PBTK NA 50% Human Human -DTXSID1044481 Css NA 0.8943 mg/L PBTK NA 95% Human Human -DTXSID1044481 Clint NA 6.271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044481 Fup NA 0.3353 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044481 Vd NA 0.9702 L/kg 1compartment NA NA Rat Human -DTXSID1044481 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044481 TK.Half.Life NA 1.257 hours 1compartment NA NA Rat Human -DTXSID1044481 Css NA 0.1067 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044481 Css NA 0.4846 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044481 Css NA 0.07804 mg/L PBTK NA 50% Rat Human -DTXSID1044481 Css NA 0.3119 mg/L PBTK NA 95% Rat Human -DTXSID1044485 Clint NA 0.03394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044485 Fup NA 0.5038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044485 Vd NA 0.3851 L/kg 1compartment NA NA Human Human +DTXSID1044439 TK.Half.Life NA 3.036 hours 1compartment NA NA Rat Human +DTXSID1044439 Css NA 0.06128 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044439 Css NA 0.4098 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044439 Css NA 0.05276 mg/L PBTK NA 50% Rat Human +DTXSID1044439 Css NA 0.2545 mg/L PBTK NA 95% Rat Human +DTXSID1044481 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044481 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044481 Vd NA 1.548 L/kg 1compartment NA NA Human Human +DTXSID1044481 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID1044481 TK.Half.Life NA 52.12 hours 1compartment NA NA Human Human +DTXSID1044481 Css NA 3.617 mg/L 3compartmentss NA 50% Human Human +DTXSID1044481 Css NA 12.74 mg/L 3compartmentss NA 95% Human Human +DTXSID1044481 Css NA 2.686 mg/L PBTK NA 50% Human Human +DTXSID1044481 Css NA 8.284 mg/L PBTK NA 95% Human Human +DTXSID1044481 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044481 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044481 Vd NA 1.235 L/kg 1compartment NA NA Rat Human +DTXSID1044481 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1044481 TK.Half.Life NA 11.48 hours 1compartment NA NA Rat Human +DTXSID1044481 Css NA 0.2278 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044481 Css NA 0.6968 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044481 Css NA 0.1684 mg/L PBTK NA 50% Rat Human +DTXSID1044481 Css NA 0.4379 mg/L PBTK NA 95% Rat Human +DTXSID1044485 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044485 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044485 Vd NA 0.4615 L/kg 1compartment NA NA Human Human DTXSID1044485 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044485 TK.Half.Life NA 4.68 hours 1compartment NA NA Human Human -DTXSID1044485 Css NA 1.476 mg/L 3compartmentss NA 50% Human Human -DTXSID1044485 Css NA 7.133 mg/L 3compartmentss NA 95% Human Human -DTXSID1044485 Css NA 1.032 mg/L PBTK NA 50% Human Human -DTXSID1044485 Css NA 4.372 mg/L PBTK NA 95% Human Human -DTXSID1044485 Clint NA 0.03394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044485 Fup NA 0.5038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044485 Vd NA 0.3962 L/kg 1compartment NA NA Rat Human +DTXSID1044485 TK.Half.Life NA 4.303 hours 1compartment NA NA Human Human +DTXSID1044485 Css NA 1.154 mg/L 3compartmentss NA 50% Human Human +DTXSID1044485 Css NA 7.287 mg/L 3compartmentss NA 95% Human Human +DTXSID1044485 Css NA 0.8543 mg/L PBTK NA 50% Human Human +DTXSID1044485 Css NA 4.508 mg/L PBTK NA 95% Human Human +DTXSID1044485 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044485 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044485 Vd NA 0.475 L/kg 1compartment NA NA Rat Human DTXSID1044485 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044485 TK.Half.Life NA 1.687 hours 1compartment NA NA Rat Human -DTXSID1044485 Css NA 0.42 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044485 Css NA 1.884 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044485 Css NA 0.2794 mg/L PBTK NA 50% Rat Human -DTXSID1044485 Css NA 1.079 mg/L PBTK NA 95% Rat Human -DTXSID1044487 Clint NA 356.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044487 Fup NA 0.1157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044487 Vd NA 4.633 L/kg 1compartment NA NA Human Human -DTXSID1044487 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044487 TK.Half.Life NA 2.134 hours 1compartment NA NA Human Human -DTXSID1044487 Css NA 0.001126 mg/L 3compartmentss NA 50% Human Human -DTXSID1044487 Css NA 0.01001 mg/L 3compartmentss NA 95% Human Human -DTXSID1044487 Css NA 0.00129 mg/L PBTK NA 50% Human Human -DTXSID1044487 Css NA 0.00938 mg/L PBTK NA 95% Human Human -DTXSID1044487 Clint NA 356.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044487 Fup NA 0.1157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044487 Vd NA 4.291 L/kg 1compartment NA NA Rat Human -DTXSID1044487 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044487 TK.Half.Life NA 0.8621 hours 1compartment NA NA Rat Human -DTXSID1044487 Css NA 0.0006076 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044487 Css NA 0.00417 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044487 Css NA 0.0006991 mg/L PBTK NA 50% Rat Human -DTXSID1044487 Css NA 0.003928 mg/L PBTK NA 95% Rat Human -DTXSID1044489 Clint NA 0.07564 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044489 Fup NA 0.5023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044489 Vd NA 0.3834 L/kg 1compartment NA NA Human Human +DTXSID1044485 TK.Half.Life NA 1.509 hours 1compartment NA NA Rat Human +DTXSID1044485 Css NA 0.07062 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044485 Css NA 0.4154 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044485 Css NA 0.05166 mg/L PBTK NA 50% Rat Human +DTXSID1044485 Css NA 0.2473 mg/L PBTK NA 95% Rat Human +DTXSID1044489 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044489 Fup 0.841 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044489 Vd NA 0.7976 L/kg 1compartment NA NA Human Human DTXSID1044489 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044489 TK.Half.Life NA 4.39 hours 1compartment NA NA Human Human -DTXSID1044489 Css NA 1.371 mg/L 3compartmentss NA 50% Human Human -DTXSID1044489 Css NA 6.658 mg/L 3compartmentss NA 95% Human Human -DTXSID1044489 Css NA 0.9536 mg/L PBTK NA 50% Human Human -DTXSID1044489 Css NA 4.103 mg/L PBTK NA 95% Human Human -DTXSID1044489 Clint NA 0.07564 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044489 Fup NA 0.5023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044489 Vd NA 0.3957 L/kg 1compartment NA NA Rat Human +DTXSID1044489 TK.Half.Life NA 6.156 hours 1compartment NA NA Human Human +DTXSID1044489 Css NA 0.916 mg/L 3compartmentss NA 50% Human Human +DTXSID1044489 Css NA 5.676 mg/L 3compartmentss NA 95% Human Human +DTXSID1044489 Css NA 0.7658 mg/L PBTK NA 50% Human Human +DTXSID1044489 Css NA 3.652 mg/L PBTK NA 95% Human Human +DTXSID1044489 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044489 Fup 0.841 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044489 Vd NA 0.8173 L/kg 1compartment NA NA Rat Human DTXSID1044489 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044489 TK.Half.Life NA 1.637 hours 1compartment NA NA Rat Human -DTXSID1044489 Css NA 0.4068 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044489 Css NA 1.785 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044489 Css NA 0.2696 mg/L PBTK NA 50% Rat Human -DTXSID1044489 Css NA 1.023 mg/L PBTK NA 95% Rat Human -DTXSID1044514 Clint NA 101 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044514 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044514 Vd NA 2.839 L/kg 1compartment NA NA Human Human -DTXSID1044514 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044514 TK.Half.Life NA 9.073 hours 1compartment NA NA Human Human -DTXSID1044514 Css NA 0.3264 mg/L 3compartmentss NA 50% Human Human -DTXSID1044514 Css NA 2.284 mg/L 3compartmentss NA 95% Human Human -DTXSID1044514 Css NA 0.2229 mg/L PBTK NA 50% Human Human -DTXSID1044514 Css NA 1.49 mg/L PBTK NA 95% Human Human -DTXSID1044514 Clint NA 101 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044514 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044514 Vd NA 2.127 L/kg 1compartment NA NA Rat Human -DTXSID1044514 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044514 TK.Half.Life NA 2.005 hours 1compartment NA NA Rat Human -DTXSID1044514 Css NA 0.1868 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044514 Css NA 1.038 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044514 Css NA 0.1215 mg/L PBTK NA 50% Rat Human -DTXSID1044514 Css NA 0.6386 mg/L PBTK NA 95% Rat Human -DTXSID1044560 Clint NA 0.1432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044560 Fup NA 0.7845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044560 Vd NA 0.5382 L/kg 1compartment NA NA Human Human +DTXSID1044489 TK.Half.Life NA 2.144 hours 1compartment NA NA Rat Human +DTXSID1044489 Css NA 0.05438 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044489 Css NA 0.3111 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044489 Css NA 0.04588 mg/L PBTK NA 50% Rat Human +DTXSID1044489 Css NA 0.1949 mg/L PBTK NA 95% Rat Human +DTXSID1044514 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044514 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044514 Vd NA 2.814 L/kg 1compartment NA NA Human Human +DTXSID1044514 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1044514 TK.Half.Life NA 33.55 hours 1compartment NA NA Human Human +DTXSID1044514 Css NA 1.47 mg/L 3compartmentss NA 50% Human Human +DTXSID1044514 Css NA 9.395 mg/L 3compartmentss NA 95% Human Human +DTXSID1044514 Css NA 0.999 mg/L PBTK NA 50% Human Human +DTXSID1044514 Css NA 6.278 mg/L PBTK NA 95% Human Human +DTXSID1044514 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044514 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044514 Vd NA 2.106 L/kg 1compartment NA NA Rat Human +DTXSID1044514 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1044514 TK.Half.Life NA 6.595 hours 1compartment NA NA Rat Human +DTXSID1044514 Css NA 0.1923 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044514 Css NA 1.043 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044514 Css NA 0.1291 mg/L PBTK NA 50% Rat Human +DTXSID1044514 Css NA 0.6851 mg/L PBTK NA 95% Rat Human +DTXSID1044560 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044560 Fup 0.582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044560 Vd NA 0.7641 L/kg 1compartment NA NA Human Human DTXSID1044560 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044560 TK.Half.Life NA 3.605 hours 1compartment NA NA Human Human -DTXSID1044560 Css NA 0.869 mg/L 3compartmentss NA 50% Human Human -DTXSID1044560 Css NA 4.767 mg/L 3compartmentss NA 95% Human Human -DTXSID1044560 Css NA 0.657 mg/L PBTK NA 50% Human Human -DTXSID1044560 Css NA 2.995 mg/L PBTK NA 95% Human Human -DTXSID1044560 Clint NA 0.1432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044560 Fup NA 0.7845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044560 Vd NA 0.5523 L/kg 1compartment NA NA Rat Human +DTXSID1044560 TK.Half.Life NA 0.715 hours 1compartment NA NA Human Human +DTXSID1044560 Css NA 0.03494 mg/L 3compartmentss NA 50% Human Human +DTXSID1044560 Css NA 0.3844 mg/L 3compartmentss NA 95% Human Human +DTXSID1044560 Css NA 0.02698 mg/L PBTK NA 50% Human Human +DTXSID1044560 Css NA 0.2572 mg/L PBTK NA 95% Human Human +DTXSID1044560 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044560 Fup 0.582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044560 Vd NA 0.7115 L/kg 1compartment NA NA Rat Human DTXSID1044560 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044560 TK.Half.Life NA 1.394 hours 1compartment NA NA Rat Human -DTXSID1044560 Css NA 0.2509 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044560 Css NA 1.467 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044560 Css NA 0.1828 mg/L PBTK NA 50% Rat Human -DTXSID1044560 Css NA 0.8517 mg/L PBTK NA 95% Rat Human +DTXSID1044560 TK.Half.Life NA 0.3284 hours 1compartment NA NA Rat Human +DTXSID1044560 Css NA 0.00416 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044560 Css NA 0.03884 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044560 Css NA 0.0033 mg/L PBTK NA 50% Rat Human +DTXSID1044560 Css NA 0.02545 mg/L PBTK NA 95% Rat Human +DTXSID1044562 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044562 Fup 0.0817 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044562 Vd NA 0.2245 L/kg 1compartment NA NA Human Human +DTXSID1044562 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1044562 TK.Half.Life NA 17.78 hours 1compartment NA NA Human Human +DTXSID1044562 Css NA 6.875 mg/L 3compartmentss NA 50% Human Human +DTXSID1044562 Css NA 34.38 mg/L 3compartmentss NA 95% Human Human +DTXSID1044562 Css NA 4.144 mg/L PBTK NA 50% Human Human +DTXSID1044562 Css NA 20.13 mg/L PBTK NA 95% Human Human +DTXSID1044562 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044562 Fup 0.0817 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044562 Vd NA 0.2304 L/kg 1compartment NA NA Rat Human +DTXSID1044562 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1044562 TK.Half.Life NA 6.217 hours 1compartment NA NA Rat Human +DTXSID1044562 Css NA 0.03832 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044562 Css NA 0.1756 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044562 Css NA 0.02164 mg/L PBTK NA 50% Rat Human +DTXSID1044562 Css NA 0.09642 mg/L PBTK NA 95% Rat Human DTXSID1044564 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1044564 Fup 0.0383 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1044564 Vd NA 0.3323 L/kg 1compartment NA NA Human Human +DTXSID1044564 Vd NA 0.3178 L/kg 1compartment NA NA Human Human DTXSID1044564 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID1044564 TK.Half.Life NA 56.13 hours 1compartment NA NA Human Human -DTXSID1044564 Css NA 21.15 mg/L 3compartmentss NA 50% Human Human -DTXSID1044564 Css NA 92.72 mg/L 3compartmentss NA 95% Human Human -DTXSID1044564 Css NA 12.88 mg/L PBTK NA 50% Human Human -DTXSID1044564 Css NA 54.72 mg/L PBTK NA 95% Human Human +DTXSID1044564 TK.Half.Life NA 53.69 hours 1compartment NA NA Human Human +DTXSID1044564 Css NA 20.39 mg/L 3compartmentss NA 50% Human Human +DTXSID1044564 Css NA 89.95 mg/L 3compartmentss NA 95% Human Human +DTXSID1044564 Css NA 12.32 mg/L PBTK NA 50% Human Human +DTXSID1044564 Css NA 52.66 mg/L PBTK NA 95% Human Human DTXSID1044564 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1044564 Fup 0.0383 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1044564 Vd NA 0.3234 L/kg 1compartment NA NA Rat Human +DTXSID1044564 Vd NA 0.31 L/kg 1compartment NA NA Rat Human DTXSID1044564 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1044564 TK.Half.Life NA 18.62 hours 1compartment NA NA Rat Human -DTXSID1044564 Css NA 5.931 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044564 Css NA 22.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044564 Css NA 3.374 mg/L PBTK NA 50% Rat Human -DTXSID1044564 Css NA 12.09 mg/L PBTK NA 95% Rat Human -DTXSID1044568 Clint NA 14.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044568 Fup NA 0.2201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044568 Vd NA 2.823 L/kg 1compartment NA NA Human Human +DTXSID1044564 TK.Half.Life NA 17.85 hours 1compartment NA NA Rat Human +DTXSID1044564 Css NA 1.239 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044564 Css NA 4.64 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044564 Css NA 0.7272 mg/L PBTK NA 50% Rat Human +DTXSID1044564 Css NA 2.625 mg/L PBTK NA 95% Rat Human +DTXSID1044568 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044568 Fup 0.054 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044568 Vd NA 2.384 L/kg 1compartment NA NA Human Human DTXSID1044568 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1044568 TK.Half.Life NA 14.45 hours 1compartment NA NA Human Human -DTXSID1044568 Css NA 0.5311 mg/L 3compartmentss NA 50% Human Human -DTXSID1044568 Css NA 3.032 mg/L 3compartmentss NA 95% Human Human -DTXSID1044568 Css NA 0.3811 mg/L PBTK NA 50% Human Human -DTXSID1044568 Css NA 2.102 mg/L PBTK NA 95% Human Human -DTXSID1044568 Clint NA 14.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044568 Fup NA 0.2201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044568 Vd NA 2.139 L/kg 1compartment NA NA Rat Human +DTXSID1044568 TK.Half.Life NA 14.85 hours 1compartment NA NA Human Human +DTXSID1044568 Css NA 0.7748 mg/L 3compartmentss NA 50% Human Human +DTXSID1044568 Css NA 5.459 mg/L 3compartmentss NA 95% Human Human +DTXSID1044568 Css NA 0.5177 mg/L PBTK NA 50% Human Human +DTXSID1044568 Css NA 3.514 mg/L PBTK NA 95% Human Human +DTXSID1044568 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044568 Fup 0.054 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044568 Vd NA 1.787 L/kg 1compartment NA NA Rat Human DTXSID1044568 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044568 TK.Half.Life NA 3.067 hours 1compartment NA NA Rat Human -DTXSID1044568 Css NA 0.2857 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044568 Css NA 1.287 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044568 Css NA 0.198 mg/L PBTK NA 50% Rat Human -DTXSID1044568 Css NA 0.8641 mg/L PBTK NA 95% Rat Human -DTXSID1044645 Clint NA 9.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044645 Fup NA 0.4263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044645 Vd NA 1.403 L/kg 1compartment NA NA Human Human +DTXSID1044568 TK.Half.Life NA 4.046 hours 1compartment NA NA Rat Human +DTXSID1044568 Css NA 0.1004 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044568 Css NA 0.5683 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044568 Css NA 0.06609 mg/L PBTK NA 50% Rat Human +DTXSID1044568 Css NA 0.3563 mg/L PBTK NA 95% Rat Human +DTXSID1044645 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044645 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044645 Vd NA 1.54 L/kg 1compartment NA NA Human Human DTXSID1044645 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044645 TK.Half.Life NA 2.102 hours 1compartment NA NA Human Human -DTXSID1044645 Css NA 0.09864 mg/L 3compartmentss NA 50% Human Human -DTXSID1044645 Css NA 0.7532 mg/L 3compartmentss NA 95% Human Human -DTXSID1044645 Css NA 0.08376 mg/L PBTK NA 50% Human Human -DTXSID1044645 Css NA 0.5444 mg/L PBTK NA 95% Human Human -DTXSID1044645 Clint NA 9.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044645 Fup NA 0.4263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044645 Vd NA 1.384 L/kg 1compartment NA NA Rat Human +DTXSID1044645 TK.Half.Life NA 2.885 hours 1compartment NA NA Human Human +DTXSID1044645 Css NA 0.1334 mg/L 3compartmentss NA 50% Human Human +DTXSID1044645 Css NA 0.978 mg/L 3compartmentss NA 95% Human Human +DTXSID1044645 Css NA 0.115 mg/L PBTK NA 50% Human Human +DTXSID1044645 Css NA 0.7074 mg/L PBTK NA 95% Human Human +DTXSID1044645 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044645 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044645 Vd NA 1.507 L/kg 1compartment NA NA Rat Human DTXSID1044645 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044645 TK.Half.Life NA 1.144 hours 1compartment NA NA Rat Human -DTXSID1044645 Css NA 0.05047 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044645 Css NA 0.3036 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044645 Css NA 0.0417 mg/L PBTK NA 50% Rat Human -DTXSID1044645 Css NA 0.2049 mg/L PBTK NA 95% Rat Human -DTXSID1044691 Clint NA 21.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044691 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044691 Vd NA 3.081 L/kg 1compartment NA NA Human Human -DTXSID1044691 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID1044691 TK.Half.Life NA 74 hours 1compartment NA NA Human Human -DTXSID1044691 Css NA 2.951 mg/L 3compartmentss NA 50% Human Human -DTXSID1044691 Css NA 19.06 mg/L 3compartmentss NA 95% Human Human -DTXSID1044691 Css NA 2.04 mg/L PBTK NA 50% Human Human -DTXSID1044691 Css NA 12.86 mg/L PBTK NA 95% Human Human -DTXSID1044691 Clint NA 21.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044691 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044691 Vd NA 2.308 L/kg 1compartment NA NA Rat Human -DTXSID1044691 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID1044691 TK.Half.Life NA 10.59 hours 1compartment NA NA Rat Human -DTXSID1044691 Css NA 1.661 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044691 Css NA 8.479 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044691 Css NA 1.098 mg/L PBTK NA 50% Rat Human -DTXSID1044691 Css NA 5.427 mg/L PBTK NA 95% Rat Human -DTXSID1044693 Clint NA 0.03393 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044693 Fup NA 0.1766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044693 Vd NA 0.3792 L/kg 1compartment NA NA Human Human -DTXSID1044693 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1044693 TK.Half.Life NA 13.16 hours 1compartment NA NA Human Human -DTXSID1044693 Css NA 4.26 mg/L 3compartmentss NA 50% Human Human -DTXSID1044693 Css NA 16.23 mg/L 3compartmentss NA 95% Human Human -DTXSID1044693 Css NA 2.838 mg/L PBTK NA 50% Human Human -DTXSID1044693 Css NA 9.924 mg/L PBTK NA 95% Human Human -DTXSID1044693 Clint NA 0.03393 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044693 Fup NA 0.1766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044693 Vd NA 0.376 L/kg 1compartment NA NA Rat Human +DTXSID1044645 TK.Half.Life NA 1.569 hours 1compartment NA NA Rat Human +DTXSID1044645 Css NA 0.01531 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044645 Css NA 0.08575 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044645 Css NA 0.0134 mg/L PBTK NA 50% Rat Human +DTXSID1044645 Css NA 0.05946 mg/L PBTK NA 95% Rat Human +DTXSID1044647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044647 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044647 Vd NA 0.7622 L/kg 1compartment NA NA Human Human +DTXSID1044647 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1044647 TK.Half.Life NA 1.015 hours 1compartment NA NA Human Human +DTXSID1044647 Css NA 0.05844 mg/L 3compartmentss NA 50% Human Human +DTXSID1044647 Css NA 0.4632 mg/L 3compartmentss NA 95% Human Human +DTXSID1044647 Css NA 0.04248 mg/L PBTK NA 50% Human Human +DTXSID1044647 Css NA 0.3068 mg/L PBTK NA 95% Human Human +DTXSID1044647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044647 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044647 Vd NA 0.7563 L/kg 1compartment NA NA Rat Human +DTXSID1044647 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1044647 TK.Half.Life NA 0.5424 hours 1compartment NA NA Rat Human +DTXSID1044647 Css NA 0.002064 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044647 Css NA 0.01886 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044647 Css NA 0.001468 mg/L PBTK NA 50% Rat Human +DTXSID1044647 Css NA 0.01231 mg/L PBTK NA 95% Rat Human +DTXSID1044691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044691 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044691 Vd NA 3.08 L/kg 1compartment NA NA Human Human +DTXSID1044691 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID1044691 TK.Half.Life NA 84.34 hours 1compartment NA NA Human Human +DTXSID1044691 Css NA 3.296 mg/L 3compartmentss NA 50% Human Human +DTXSID1044691 Css NA 21.76 mg/L 3compartmentss NA 95% Human Human +DTXSID1044691 Css NA 2.272 mg/L PBTK NA 50% Human Human +DTXSID1044691 Css NA 14.69 mg/L PBTK NA 95% Human Human +DTXSID1044691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044691 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044691 Vd NA 2.306 L/kg 1compartment NA NA Rat Human +DTXSID1044691 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID1044691 TK.Half.Life NA 12.01 hours 1compartment NA NA Rat Human +DTXSID1044691 Css NA 0.4272 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044691 Css NA 2.277 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044691 Css NA 0.2926 mg/L PBTK NA 50% Rat Human +DTXSID1044691 Css NA 1.52 mg/L PBTK NA 95% Rat Human +DTXSID1044693 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044693 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044693 Vd NA 0.4552 L/kg 1compartment NA NA Human Human +DTXSID1044693 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1044693 TK.Half.Life NA 1.042 hours 1compartment NA NA Human Human +DTXSID1044693 Css NA 0.1924 mg/L 3compartmentss NA 50% Human Human +DTXSID1044693 Css NA 1.228 mg/L 3compartmentss NA 95% Human Human +DTXSID1044693 Css NA 0.1376 mg/L PBTK NA 50% Human Human +DTXSID1044693 Css NA 0.8026 mg/L PBTK NA 95% Human Human +DTXSID1044693 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044693 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044693 Vd NA 0.4577 L/kg 1compartment NA NA Rat Human DTXSID1044693 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044693 TK.Half.Life NA 4.569 hours 1compartment NA NA Rat Human -DTXSID1044693 Css NA 1.248 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044693 Css NA 3.992 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044693 Css NA 0.7844 mg/L PBTK NA 50% Rat Human -DTXSID1044693 Css NA 2.278 mg/L PBTK NA 95% Rat Human -DTXSID1044697 Clint NA 2.818 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044697 Fup NA 0.2519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044697 Vd NA 2.792 L/kg 1compartment NA NA Human Human -DTXSID1044697 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID1044697 TK.Half.Life NA 47.12 hours 1compartment NA NA Human Human -DTXSID1044697 Css NA 1.932 mg/L 3compartmentss NA 50% Human Human -DTXSID1044697 Css NA 8.463 mg/L 3compartmentss NA 95% Human Human -DTXSID1044697 Css NA 1.404 mg/L PBTK NA 50% Human Human -DTXSID1044697 Css NA 5.962 mg/L PBTK NA 95% Human Human -DTXSID1044697 Clint NA 2.818 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044697 Fup NA 0.2519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044697 Vd NA 2.12 L/kg 1compartment NA NA Rat Human -DTXSID1044697 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID1044697 TK.Half.Life NA 8.847 hours 1compartment NA NA Rat Human -DTXSID1044697 Css NA 0.9407 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044697 Css NA 2.897 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044697 Css NA 0.6593 mg/L PBTK NA 50% Rat Human -DTXSID1044697 Css NA 1.896 mg/L PBTK NA 95% Rat Human -DTXSID1044720 Clint NA 0.8465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044720 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044720 Vd NA 2.374 L/kg 1compartment NA NA Human Human +DTXSID1044693 TK.Half.Life NA 0.5924 hours 1compartment NA NA Rat Human +DTXSID1044693 Css NA 0.0229 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044693 Css NA 0.1069 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044693 Css NA 0.01624 mg/L PBTK NA 50% Rat Human +DTXSID1044693 Css NA 0.06773 mg/L PBTK NA 95% Rat Human +DTXSID1044699 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044699 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044699 Vd NA 0.8706 L/kg 1compartment NA NA Human Human +DTXSID1044699 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1044699 TK.Half.Life NA 7.254 hours 1compartment NA NA Human Human +DTXSID1044699 Css NA 0.8334 mg/L 3compartmentss NA 50% Human Human +DTXSID1044699 Css NA 5.293 mg/L 3compartmentss NA 95% Human Human +DTXSID1044699 Css NA 0.7112 mg/L PBTK NA 50% Human Human +DTXSID1044699 Css NA 3.443 mg/L PBTK NA 95% Human Human +DTXSID1044699 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044699 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044699 Vd NA 0.8702 L/kg 1compartment NA NA Rat Human +DTXSID1044699 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1044699 TK.Half.Life NA 2.453 hours 1compartment NA NA Rat Human +DTXSID1044699 Css NA 0.01543 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044699 Css NA 0.1229 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044699 Css NA 0.0127 mg/L PBTK NA 50% Rat Human +DTXSID1044699 Css NA 0.08116 mg/L PBTK NA 95% Rat Human +DTXSID1044720 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044720 Fup 0.69 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044720 Vd NA 1.845 L/kg 1compartment NA NA Human Human DTXSID1044720 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044720 TK.Half.Life NA 6.822 hours 1compartment NA NA Human Human -DTXSID1044720 Css NA 0.2712 mg/L 3compartmentss NA 50% Human Human -DTXSID1044720 Css NA 2.132 mg/L 3compartmentss NA 95% Human Human -DTXSID1044720 Css NA 0.2916 mg/L PBTK NA 50% Human Human -DTXSID1044720 Css NA 1.562 mg/L PBTK NA 95% Human Human -DTXSID1044720 Clint NA 0.8465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044720 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044720 Vd NA 2.403 L/kg 1compartment NA NA Rat Human +DTXSID1044720 TK.Half.Life NA 1.375 hours 1compartment NA NA Human Human +DTXSID1044720 Css NA 0.02017 mg/L 3compartmentss NA 50% Human Human +DTXSID1044720 Css NA 0.2447 mg/L 3compartmentss NA 95% Human Human +DTXSID1044720 Css NA 0.01913 mg/L PBTK NA 50% Human Human +DTXSID1044720 Css NA 0.1908 mg/L PBTK NA 95% Human Human +DTXSID1044720 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044720 Fup 0.69 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044720 Vd NA 1.858 L/kg 1compartment NA NA Rat Human DTXSID1044720 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044720 TK.Half.Life NA 3.236 hours 1compartment NA NA Rat Human -DTXSID1044720 Css NA 0.09706 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044720 Css NA 0.769 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044720 Css NA 0.105 mg/L PBTK NA 50% Rat Human -DTXSID1044720 Css NA 0.5003 mg/L PBTK NA 95% Rat Human -DTXSID1044722 Clint NA 5.066 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044722 Fup NA 0.365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044722 Vd NA 0.5024 L/kg 1compartment NA NA Human Human +DTXSID1044720 TK.Half.Life NA 0.6939 hours 1compartment NA NA Rat Human +DTXSID1044720 Css NA 0.0006951 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044720 Css NA 0.0107 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044720 Css NA 0.0006656 mg/L PBTK NA 50% Rat Human +DTXSID1044720 Css NA 0.007859 mg/L PBTK NA 95% Rat Human +DTXSID1044722 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044722 Fup 0.352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044722 Vd NA 0.4514 L/kg 1compartment NA NA Human Human DTXSID1044722 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044722 TK.Half.Life NA 1.228 hours 1compartment NA NA Human Human -DTXSID1044722 Css NA 0.2215 mg/L 3compartmentss NA 50% Human Human -DTXSID1044722 Css NA 1.334 mg/L 3compartmentss NA 95% Human Human -DTXSID1044722 Css NA 0.1618 mg/L PBTK NA 50% Human Human -DTXSID1044722 Css NA 0.8774 mg/L PBTK NA 95% Human Human -DTXSID1044722 Clint NA 5.066 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044722 Fup NA 0.365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044722 Vd NA 0.5095 L/kg 1compartment NA NA Rat Human +DTXSID1044722 TK.Half.Life NA 8.297 hours 1compartment NA NA Human Human +DTXSID1044722 Css NA 1.123 mg/L 3compartmentss NA 50% Human Human +DTXSID1044722 Css NA 5.082 mg/L 3compartmentss NA 95% Human Human +DTXSID1044722 Css NA 0.8044 mg/L PBTK NA 50% Human Human +DTXSID1044722 Css NA 3.206 mg/L PBTK NA 95% Human Human +DTXSID1044722 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044722 Fup 0.352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044722 Vd NA 0.4618 L/kg 1compartment NA NA Rat Human DTXSID1044722 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044722 TK.Half.Life NA 0.7028 hours 1compartment NA NA Rat Human -DTXSID1044722 Css NA 0.11 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044722 Css NA 0.5205 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044722 Css NA 0.07661 mg/L PBTK NA 50% Rat Human -DTXSID1044722 Css NA 0.3205 mg/L PBTK NA 95% Rat Human +DTXSID1044722 TK.Half.Life NA 2.892 hours 1compartment NA NA Rat Human +DTXSID1044722 Css NA 0.006095 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044722 Css NA 0.02693 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044722 Css NA 0.004168 mg/L PBTK NA 50% Rat Human +DTXSID1044722 Css NA 0.01644 mg/L PBTK NA 95% Rat Human DTXSID1044724 Clint NA 0.007208 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1044724 Fup NA 0.6764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044724 Vd NA 2.163 L/kg 1compartment NA NA Human Human -DTXSID1044724 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1044724 TK.Half.Life NA 33.71 hours 1compartment NA NA Human Human -DTXSID1044724 Css NA 1.524 mg/L 3compartmentss NA 50% Human Human -DTXSID1044724 Css NA 8.126 mg/L 3compartmentss NA 95% Human Human -DTXSID1044724 Css NA 1.353 mg/L PBTK NA 50% Human Human -DTXSID1044724 Css NA 5.542 mg/L PBTK NA 95% Human Human +DTXSID1044724 Vd NA 0.5462 L/kg 1compartment NA NA Human Human +DTXSID1044724 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1044724 TK.Half.Life NA 5.154 hours 1compartment NA NA Human Human +DTXSID1044724 Css NA 0.9625 mg/L 3compartmentss NA 50% Human Human +DTXSID1044724 Css NA 6.1 mg/L 3compartmentss NA 95% Human Human +DTXSID1044724 Css NA 0.7502 mg/L PBTK NA 50% Human Human +DTXSID1044724 Css NA 3.86 mg/L PBTK NA 95% Human Human DTXSID1044724 Clint NA 0.007208 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1044724 Fup NA 0.6764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044724 Vd NA 1.767 L/kg 1compartment NA NA Rat Human +DTXSID1044724 Vd NA 0.5697 L/kg 1compartment NA NA Rat Human DTXSID1044724 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044724 TK.Half.Life NA 6.608 hours 1compartment NA NA Rat Human -DTXSID1044724 Css NA 0.4104 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044724 Css NA 2.242 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044724 Css NA 0.3536 mg/L PBTK NA 50% Rat Human -DTXSID1044724 Css NA 1.393 mg/L PBTK NA 95% Rat Human -DTXSID1044770 Clint NA 106.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044770 Fup NA 0.2896 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044770 Vd NA 1.431 L/kg 1compartment NA NA Human Human +DTXSID1044724 TK.Half.Life NA 1.844 hours 1compartment NA NA Rat Human +DTXSID1044724 Css NA 0.01906 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044724 Css NA 0.157 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044724 Css NA 0.01422 mg/L PBTK NA 50% Rat Human +DTXSID1044724 Css NA 0.09684 mg/L PBTK NA 95% Rat Human +DTXSID1044728 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044728 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044728 Vd NA 0.6815 L/kg 1compartment NA NA Human Human +DTXSID1044728 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1044728 TK.Half.Life NA 1.388 hours 1compartment NA NA Human Human +DTXSID1044728 Css NA 0.1571 mg/L 3compartmentss NA 50% Human Human +DTXSID1044728 Css NA 1.304 mg/L 3compartmentss NA 95% Human Human +DTXSID1044728 Css NA 0.1031 mg/L PBTK NA 50% Human Human +DTXSID1044728 Css NA 0.8109 mg/L PBTK NA 95% Human Human +DTXSID1044728 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044728 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044728 Vd NA 0.5677 L/kg 1compartment NA NA Rat Human +DTXSID1044728 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1044728 TK.Half.Life NA 0.649 hours 1compartment NA NA Rat Human +DTXSID1044728 Css NA 0.007573 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044728 Css NA 0.0701 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044728 Css NA 0.004848 mg/L PBTK NA 50% Rat Human +DTXSID1044728 Css NA 0.04255 mg/L PBTK NA 95% Rat Human +DTXSID1044770 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044770 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044770 Vd NA 1.567 L/kg 1compartment NA NA Human Human DTXSID1044770 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044770 TK.Half.Life NA 1.241 hours 1compartment NA NA Human Human -DTXSID1044770 Css NA 0.01736 mg/L 3compartmentss NA 50% Human Human -DTXSID1044770 Css NA 0.1252 mg/L 3compartmentss NA 95% Human Human -DTXSID1044770 Css NA 0.01304 mg/L PBTK NA 50% Human Human -DTXSID1044770 Css NA 0.08625 mg/L PBTK NA 95% Human Human -DTXSID1044770 Clint NA 106.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044770 Fup NA 0.2896 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044770 Vd NA 1.161 L/kg 1compartment NA NA Rat Human +DTXSID1044770 TK.Half.Life NA 4.997 hours 1compartment NA NA Human Human +DTXSID1044770 Css NA 0.2936 mg/L 3compartmentss NA 50% Human Human +DTXSID1044770 Css NA 1.694 mg/L 3compartmentss NA 95% Human Human +DTXSID1044770 Css NA 0.2189 mg/L PBTK NA 50% Human Human +DTXSID1044770 Css NA 1.171 mg/L PBTK NA 95% Human Human +DTXSID1044770 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044770 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044770 Vd NA 1.253 L/kg 1compartment NA NA Rat Human DTXSID1044770 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044770 TK.Half.Life NA 0.4584 hours 1compartment NA NA Rat Human -DTXSID1044770 Css NA 0.00959 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044770 Css NA 0.05833 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044770 Css NA 0.006934 mg/L PBTK NA 50% Rat Human -DTXSID1044770 Css NA 0.03876 mg/L PBTK NA 95% Rat Human -DTXSID1044774 Clint NA 19.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044774 Fup NA 0.153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044774 Vd NA 2.88 L/kg 1compartment NA NA Human Human -DTXSID1044774 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1044774 TK.Half.Life NA 16.86 hours 1compartment NA NA Human Human -DTXSID1044774 Css NA 0.6454 mg/L 3compartmentss NA 50% Human Human -DTXSID1044774 Css NA 4.014 mg/L 3compartmentss NA 95% Human Human -DTXSID1044774 Css NA 0.4572 mg/L PBTK NA 50% Human Human -DTXSID1044774 Css NA 2.733 mg/L PBTK NA 95% Human Human -DTXSID1044774 Clint NA 19.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044774 Fup NA 0.153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044774 Vd NA 2.171 L/kg 1compartment NA NA Rat Human -DTXSID1044774 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044774 TK.Half.Life NA 3.36 hours 1compartment NA NA Rat Human -DTXSID1044774 Css NA 0.3567 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044774 Css NA 1.775 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044774 Css NA 0.2401 mg/L PBTK NA 50% Rat Human -DTXSID1044774 Css NA 1.15 mg/L PBTK NA 95% Rat Human -DTXSID1044776 Clint NA 0.02027 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044776 Fup NA 0.9593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044776 Vd NA 1.028 L/kg 1compartment NA NA Human Human +DTXSID1044770 TK.Half.Life NA 1.969 hours 1compartment NA NA Rat Human +DTXSID1044770 Css NA 0.03484 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044770 Css NA 0.146 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044770 Css NA 0.02597 mg/L PBTK NA 50% Rat Human +DTXSID1044770 Css NA 0.09748 mg/L PBTK NA 95% Rat Human +DTXSID1044774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044774 Fup 0.0361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044774 Vd NA 2.816 L/kg 1compartment NA NA Human Human +DTXSID1044774 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1044774 TK.Half.Life NA 33.16 hours 1compartment NA NA Human Human +DTXSID1044774 Css NA 1.471 mg/L 3compartmentss NA 50% Human Human +DTXSID1044774 Css NA 9.77 mg/L 3compartmentss NA 95% Human Human +DTXSID1044774 Css NA 1.003 mg/L PBTK NA 50% Human Human +DTXSID1044774 Css NA 6.361 mg/L PBTK NA 95% Human Human +DTXSID1044774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044774 Fup 0.0361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044774 Vd NA 2.108 L/kg 1compartment NA NA Rat Human +DTXSID1044774 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1044774 TK.Half.Life NA 6.521 hours 1compartment NA NA Rat Human +DTXSID1044774 Css NA 0.1915 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044774 Css NA 1.052 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044774 Css NA 0.1282 mg/L PBTK NA 50% Rat Human +DTXSID1044774 Css NA 0.6937 mg/L PBTK NA 95% Rat Human +DTXSID1044776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044776 Fup 0.617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044776 Vd NA 0.7881 L/kg 1compartment NA NA Human Human DTXSID1044776 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044776 TK.Half.Life NA 6.816 hours 1compartment NA NA Human Human -DTXSID1044776 Css NA 0.805 mg/L 3compartmentss NA 50% Human Human -DTXSID1044776 Css NA 4.759 mg/L 3compartmentss NA 95% Human Human -DTXSID1044776 Css NA 0.7106 mg/L PBTK NA 50% Human Human -DTXSID1044776 Css NA 3.147 mg/L PBTK NA 95% Human Human -DTXSID1044776 Clint NA 0.02027 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044776 Fup NA 0.9593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044776 Vd NA 1.02 L/kg 1compartment NA NA Rat Human +DTXSID1044776 TK.Half.Life NA 0.6999 hours 1compartment NA NA Human Human +DTXSID1044776 Css NA 0.03226 mg/L 3compartmentss NA 50% Human Human +DTXSID1044776 Css NA 0.3521 mg/L 3compartmentss NA 95% Human Human +DTXSID1044776 Css NA 0.0259 mg/L PBTK NA 50% Human Human +DTXSID1044776 Css NA 0.2367 mg/L PBTK NA 95% Human Human +DTXSID1044776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044776 Fup 0.617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044776 Vd NA 0.779 L/kg 1compartment NA NA Rat Human DTXSID1044776 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044776 TK.Half.Life NA 2.316 hours 1compartment NA NA Rat Human -DTXSID1044776 Css NA 0.2094 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044776 Css NA 1.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044776 Css NA 0.1813 mg/L PBTK NA 50% Rat Human -DTXSID1044776 Css NA 0.7435 mg/L PBTK NA 95% Rat Human +DTXSID1044776 TK.Half.Life NA 0.3425 hours 1compartment NA NA Rat Human +DTXSID1044776 Css NA 0.003921 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044776 Css NA 0.03602 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044776 Css NA 0.003193 mg/L PBTK NA 50% Rat Human +DTXSID1044776 Css NA 0.02399 mg/L PBTK NA 95% Rat Human DTXSID1044801 Clint NA 0.5935 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1044801 Fup NA 0.3898 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044801 Vd NA 0.6512 L/kg 1compartment NA NA Human Human +DTXSID1044801 Vd NA 0.4053 L/kg 1compartment NA NA Human Human DTXSID1044801 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044801 TK.Half.Life NA 5.613 hours 1compartment NA NA Human Human -DTXSID1044801 Css NA 0.9294 mg/L 3compartmentss NA 50% Human Human -DTXSID1044801 Css NA 4.363 mg/L 3compartmentss NA 95% Human Human -DTXSID1044801 Css NA 0.6959 mg/L PBTK NA 50% Human Human -DTXSID1044801 Css NA 2.789 mg/L PBTK NA 95% Human Human +DTXSID1044801 TK.Half.Life NA 3.404 hours 1compartment NA NA Human Human +DTXSID1044801 Css NA 0.8133 mg/L 3compartmentss NA 50% Human Human +DTXSID1044801 Css NA 3.847 mg/L 3compartmentss NA 95% Human Human +DTXSID1044801 Css NA 0.5709 mg/L PBTK NA 50% Human Human +DTXSID1044801 Css NA 2.408 mg/L PBTK NA 95% Human Human DTXSID1044801 Clint NA 0.5935 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1044801 Fup NA 0.3898 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044801 Vd NA 0.6281 L/kg 1compartment NA NA Rat Human +DTXSID1044801 Vd NA 0.431 L/kg 1compartment NA NA Rat Human DTXSID1044801 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044801 TK.Half.Life NA 2.427 hours 1compartment NA NA Rat Human -DTXSID1044801 Css NA 0.3428 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044801 Css NA 1.335 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044801 Css NA 0.2442 mg/L PBTK NA 50% Rat Human -DTXSID1044801 Css NA 0.7946 mg/L PBTK NA 95% Rat Human -DTXSID1044805 Clint NA 22.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044805 Fup NA 0.308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044805 Vd NA 1.256 L/kg 1compartment NA NA Human Human +DTXSID1044801 TK.Half.Life NA 1.645 hours 1compartment NA NA Rat Human +DTXSID1044801 Css NA 0.02006 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044801 Css NA 0.1282 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044801 Css NA 0.0135 mg/L PBTK NA 50% Rat Human +DTXSID1044801 Css NA 0.07945 mg/L PBTK NA 95% Rat Human +DTXSID1044805 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044805 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044805 Vd NA 1.84 L/kg 1compartment NA NA Human Human DTXSID1044805 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044805 TK.Half.Life NA 1.633 hours 1compartment NA NA Human Human -DTXSID1044805 Css NA 0.07206 mg/L 3compartmentss NA 50% Human Human -DTXSID1044805 Css NA 0.5069 mg/L 3compartmentss NA 95% Human Human -DTXSID1044805 Css NA 0.05432 mg/L PBTK NA 50% Human Human -DTXSID1044805 Css NA 0.3552 mg/L PBTK NA 95% Human Human -DTXSID1044805 Clint NA 22.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044805 Fup NA 0.308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044805 Vd NA 1.043 L/kg 1compartment NA NA Rat Human +DTXSID1044805 TK.Half.Life NA 2.47 hours 1compartment NA NA Human Human +DTXSID1044805 Css NA 0.07278 mg/L 3compartmentss NA 50% Human Human +DTXSID1044805 Css NA 0.5309 mg/L 3compartmentss NA 95% Human Human +DTXSID1044805 Css NA 0.05716 mg/L PBTK NA 50% Human Human +DTXSID1044805 Css NA 0.3796 mg/L PBTK NA 95% Human Human +DTXSID1044805 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044805 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044805 Vd NA 1.468 L/kg 1compartment NA NA Rat Human DTXSID1044805 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044805 TK.Half.Life NA 0.6843 hours 1compartment NA NA Rat Human -DTXSID1044805 Css NA 0.03865 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044805 Css NA 0.2121 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044805 Css NA 0.0281 mg/L PBTK NA 50% Rat Human -DTXSID1044805 Css NA 0.141 mg/L PBTK NA 95% Rat Human -DTXSID1044807 Clint NA 156.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044807 Fup NA 0.2522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044807 Vd NA 1.313 L/kg 1compartment NA NA Human Human +DTXSID1044805 TK.Half.Life NA 0.9077 hours 1compartment NA NA Rat Human +DTXSID1044805 Css NA 0.00909 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044805 Css NA 0.05268 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044805 Css NA 0.007106 mg/L PBTK NA 50% Rat Human +DTXSID1044805 Css NA 0.0369 mg/L PBTK NA 95% Rat Human +DTXSID1044807 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044807 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044807 Vd NA 2.823 L/kg 1compartment NA NA Human Human DTXSID1044807 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044807 TK.Half.Life NA 1.124 hours 1compartment NA NA Human Human -DTXSID1044807 Css NA 0.01337 mg/L 3compartmentss NA 50% Human Human -DTXSID1044807 Css NA 0.1013 mg/L 3compartmentss NA 95% Human Human -DTXSID1044807 Css NA 0.009853 mg/L PBTK NA 50% Human Human -DTXSID1044807 Css NA 0.06957 mg/L PBTK NA 95% Human Human -DTXSID1044807 Clint NA 156.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044807 Fup NA 0.2522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044807 Vd NA 1.066 L/kg 1compartment NA NA Rat Human +DTXSID1044807 TK.Half.Life NA 7.79 hours 1compartment NA NA Human Human +DTXSID1044807 Css NA 0.2331 mg/L 3compartmentss NA 50% Human Human +DTXSID1044807 Css NA 1.438 mg/L 3compartmentss NA 95% Human Human +DTXSID1044807 Css NA 0.1716 mg/L PBTK NA 50% Human Human +DTXSID1044807 Css NA 0.9989 mg/L PBTK NA 95% Human Human +DTXSID1044807 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044807 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044807 Vd NA 2.15 L/kg 1compartment NA NA Rat Human DTXSID1044807 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044807 TK.Half.Life NA 0.4138 hours 1compartment NA NA Rat Human -DTXSID1044807 Css NA 0.007347 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044807 Css NA 0.04448 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044807 Css NA 0.005144 mg/L PBTK NA 50% Rat Human -DTXSID1044807 Css NA 0.02925 mg/L PBTK NA 95% Rat Human -DTXSID1044809 Clint NA 27.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044809 Fup NA 0.2002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044809 Vd NA 2.459 L/kg 1compartment NA NA Human Human +DTXSID1044807 TK.Half.Life NA 1.819 hours 1compartment NA NA Rat Human +DTXSID1044807 Css NA 0.02927 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044807 Css NA 0.1429 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044807 Css NA 0.02161 mg/L PBTK NA 50% Rat Human +DTXSID1044807 Css NA 0.1025 mg/L PBTK NA 95% Rat Human +DTXSID1044809 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044809 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044809 Vd NA 2.291 L/kg 1compartment NA NA Human Human DTXSID1044809 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044809 TK.Half.Life NA 5.488 hours 1compartment NA NA Human Human -DTXSID1044809 Css NA 0.1803 mg/L 3compartmentss NA 50% Human Human -DTXSID1044809 Css NA 1.107 mg/L 3compartmentss NA 95% Human Human -DTXSID1044809 Css NA 0.1309 mg/L PBTK NA 50% Human Human -DTXSID1044809 Css NA 0.7755 mg/L PBTK NA 95% Human Human -DTXSID1044809 Clint NA 27.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044809 Fup NA 0.2002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044809 Vd NA 1.875 L/kg 1compartment NA NA Rat Human +DTXSID1044809 TK.Half.Life NA 5.071 hours 1compartment NA NA Human Human +DTXSID1044809 Css NA 0.173 mg/L 3compartmentss NA 50% Human Human +DTXSID1044809 Css NA 1.113 mg/L 3compartmentss NA 95% Human Human +DTXSID1044809 Css NA 0.1262 mg/L PBTK NA 50% Human Human +DTXSID1044809 Css NA 0.7684 mg/L PBTK NA 95% Human Human +DTXSID1044809 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044809 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044809 Vd NA 1.757 L/kg 1compartment NA NA Rat Human DTXSID1044809 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044809 TK.Half.Life NA 1.575 hours 1compartment NA NA Rat Human -DTXSID1044809 Css NA 0.09844 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044809 Css NA 0.5069 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044809 Css NA 0.06887 mg/L PBTK NA 50% Rat Human -DTXSID1044809 Css NA 0.3394 mg/L PBTK NA 95% Rat Human -DTXSID1044851 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044851 Fup NA 0.324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044851 Vd NA 0.7111 L/kg 1compartment NA NA Human Human -DTXSID1044851 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1044851 TK.Half.Life NA 14.77 hours 1compartment NA NA Human Human -DTXSID1044851 Css NA 2.348 mg/L 3compartmentss NA 50% Human Human -DTXSID1044851 Css NA 9.288 mg/L 3compartmentss NA 95% Human Human -DTXSID1044851 Css NA 1.7 mg/L PBTK NA 50% Human Human -DTXSID1044851 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID1044851 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044851 Fup NA 0.324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044851 Vd NA 0.6288 L/kg 1compartment NA NA Rat Human +DTXSID1044809 TK.Half.Life NA 1.561 hours 1compartment NA NA Rat Human +DTXSID1044809 Css NA 0.02168 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044809 Css NA 0.1091 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044809 Css NA 0.01577 mg/L PBTK NA 50% Rat Human +DTXSID1044809 Css NA 0.07666 mg/L PBTK NA 95% Rat Human +DTXSID1044851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044851 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044851 Vd NA 0.5827 L/kg 1compartment NA NA Human Human +DTXSID1044851 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1044851 TK.Half.Life NA 0.8341 hours 1compartment NA NA Human Human +DTXSID1044851 Css NA 0.08081 mg/L 3compartmentss NA 50% Human Human +DTXSID1044851 Css NA 0.5886 mg/L 3compartmentss NA 95% Human Human +DTXSID1044851 Css NA 0.05566 mg/L PBTK NA 50% Human Human +DTXSID1044851 Css NA 0.3813 mg/L PBTK NA 95% Human Human +DTXSID1044851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044851 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044851 Vd NA 0.5226 L/kg 1compartment NA NA Rat Human DTXSID1044851 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044851 TK.Half.Life NA 4.319 hours 1compartment NA NA Rat Human -DTXSID1044851 Css NA 0.6512 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044851 Css NA 2.179 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044851 Css NA 0.4501 mg/L PBTK NA 50% Rat Human -DTXSID1044851 Css NA 1.292 mg/L PBTK NA 95% Rat Human +DTXSID1044851 TK.Half.Life NA 0.3995 hours 1compartment NA NA Rat Human +DTXSID1044851 Css NA 0.01038 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044851 Css NA 0.05631 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044851 Css NA 0.007035 mg/L PBTK NA 50% Rat Human +DTXSID1044851 Css NA 0.0361 mg/L PBTK NA 95% Rat Human DTXSID1044853 Clint NA 0.4699 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1044853 Fup NA 0.3941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044853 Vd NA 0.3235 L/kg 1compartment NA NA Human Human +DTXSID1044853 Vd NA 0.5249 L/kg 1compartment NA NA Human Human DTXSID1044853 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044853 TK.Half.Life NA 3.01 hours 1compartment NA NA Human Human -DTXSID1044853 Css NA 1.122 mg/L 3compartmentss NA 50% Human Human -DTXSID1044853 Css NA 4.81 mg/L 3compartmentss NA 95% Human Human -DTXSID1044853 Css NA 0.7494 mg/L PBTK NA 50% Human Human -DTXSID1044853 Css NA 2.927 mg/L PBTK NA 95% Human Human +DTXSID1044853 TK.Half.Life NA 4.93 hours 1compartment NA NA Human Human +DTXSID1044853 Css NA 0.8821 mg/L 3compartmentss NA 50% Human Human +DTXSID1044853 Css NA 4.212 mg/L 3compartmentss NA 95% Human Human +DTXSID1044853 Css NA 0.6414 mg/L PBTK NA 50% Human Human +DTXSID1044853 Css NA 2.691 mg/L PBTK NA 95% Human Human DTXSID1044853 Clint NA 0.4699 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1044853 Fup NA 0.3941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044853 Vd NA 0.3346 L/kg 1compartment NA NA Rat Human +DTXSID1044853 Vd NA 0.533 L/kg 1compartment NA NA Rat Human DTXSID1044853 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044853 TK.Half.Life NA 1.359 hours 1compartment NA NA Rat Human -DTXSID1044853 Css NA 0.4031 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044853 Css NA 1.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044853 Css NA 0.2554 mg/L PBTK NA 50% Rat Human -DTXSID1044853 Css NA 0.8332 mg/L PBTK NA 95% Rat Human -DTXSID1044859 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044859 Fup NA 0.0818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044859 Vd NA 0.3748 L/kg 1compartment NA NA Human Human -DTXSID1044859 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1044859 TK.Half.Life NA 29.88 hours 1compartment NA NA Human Human -DTXSID1044859 Css NA 12.7 mg/L 3compartmentss NA 50% Human Human -DTXSID1044859 Css NA 58.08 mg/L 3compartmentss NA 95% Human Human -DTXSID1044859 Css NA 7.815 mg/L PBTK NA 50% Human Human -DTXSID1044859 Css NA 34.01 mg/L PBTK NA 95% Human Human -DTXSID1044859 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044859 Fup NA 0.0818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044859 Vd NA 0.3418 L/kg 1compartment NA NA Rat Human -DTXSID1044859 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044859 TK.Half.Life NA 9.23 hours 1compartment NA NA Rat Human -DTXSID1044859 Css NA 3.579 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044859 Css NA 13.84 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044859 Css NA 2.059 mg/L PBTK NA 50% Rat Human -DTXSID1044859 Css NA 7.608 mg/L PBTK NA 95% Rat Human -DTXSID1044930 Clint NA 8.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044930 Fup NA 0.1673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044930 Vd NA 0.5264 L/kg 1compartment NA NA Human Human +DTXSID1044853 TK.Half.Life NA 2.18 hours 1compartment NA NA Rat Human +DTXSID1044853 Css NA 0.02056 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044853 Css NA 0.1387 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044853 Css NA 0.01452 mg/L PBTK NA 50% Rat Human +DTXSID1044853 Css NA 0.0874 mg/L PBTK NA 95% Rat Human +DTXSID1044859 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044859 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044859 Vd NA 1.568 L/kg 1compartment NA NA Human Human +DTXSID1044859 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID1044859 TK.Half.Life NA 94.51 hours 1compartment NA NA Human Human +DTXSID1044859 Css NA 7.576 mg/L 3compartmentss NA 50% Human Human +DTXSID1044859 Css NA 30.04 mg/L 3compartmentss NA 95% Human Human +DTXSID1044859 Css NA 5.212 mg/L PBTK NA 50% Human Human +DTXSID1044859 Css NA 18.71 mg/L PBTK NA 95% Human Human +DTXSID1044859 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044859 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044859 Vd NA 1.215 L/kg 1compartment NA NA Rat Human +DTXSID1044859 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1044859 TK.Half.Life NA 19.55 hours 1compartment NA NA Rat Human +DTXSID1044859 Css NA 0.4894 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044859 Css NA 1.613 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044859 Css NA 0.3318 mg/L PBTK NA 50% Rat Human +DTXSID1044859 Css NA 0.9679 mg/L PBTK NA 95% Rat Human +DTXSID1044930 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044930 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044930 Vd NA 0.514 L/kg 1compartment NA NA Human Human DTXSID1044930 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044930 TK.Half.Life NA 1.761 hours 1compartment NA NA Human Human -DTXSID1044930 Css NA 0.368 mg/L 3compartmentss NA 50% Human Human -DTXSID1044930 Css NA 2.332 mg/L 3compartmentss NA 95% Human Human -DTXSID1044930 Css NA 0.2411 mg/L PBTK NA 50% Human Human -DTXSID1044930 Css NA 1.447 mg/L PBTK NA 95% Human Human -DTXSID1044930 Clint NA 8.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044930 Fup NA 0.1673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044930 Vd NA 0.4746 L/kg 1compartment NA NA Rat Human +DTXSID1044930 TK.Half.Life NA 0.8805 hours 1compartment NA NA Human Human +DTXSID1044930 Css NA 0.1146 mg/L 3compartmentss NA 50% Human Human +DTXSID1044930 Css NA 0.8408 mg/L 3compartmentss NA 95% Human Human +DTXSID1044930 Css NA 0.07638 mg/L PBTK NA 50% Human Human +DTXSID1044930 Css NA 0.5342 mg/L PBTK NA 95% Human Human +DTXSID1044930 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044930 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044930 Vd NA 0.473 L/kg 1compartment NA NA Rat Human DTXSID1044930 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044930 TK.Half.Life NA 0.934 hours 1compartment NA NA Rat Human -DTXSID1044930 Css NA 0.1939 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044930 Css NA 0.9228 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044930 Css NA 0.12 mg/L PBTK NA 50% Rat Human -DTXSID1044930 Css NA 0.5327 mg/L PBTK NA 95% Rat Human -DTXSID1044932 Clint NA 3.599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044932 Fup NA 0.126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044932 Vd NA 0.3574 L/kg 1compartment NA NA Human Human +DTXSID1044930 TK.Half.Life NA 0.4486 hours 1compartment NA NA Rat Human +DTXSID1044930 Css NA 0.01455 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044930 Css NA 0.07806 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044930 Css NA 0.009568 mg/L PBTK NA 50% Rat Human +DTXSID1044930 Css NA 0.04859 mg/L PBTK NA 95% Rat Human +DTXSID1044932 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044932 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044932 Vd NA 0.5242 L/kg 1compartment NA NA Human Human DTXSID1044932 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044932 TK.Half.Life NA 2.843 hours 1compartment NA NA Human Human -DTXSID1044932 Css NA 1.165 mg/L 3compartmentss NA 50% Human Human -DTXSID1044932 Css NA 7.255 mg/L 3compartmentss NA 95% Human Human -DTXSID1044932 Css NA 0.7462 mg/L PBTK NA 50% Human Human -DTXSID1044932 Css NA 4.425 mg/L PBTK NA 95% Human Human -DTXSID1044932 Clint NA 3.599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044932 Fup NA 0.126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044932 Vd NA 0.3573 L/kg 1compartment NA NA Rat Human +DTXSID1044932 TK.Half.Life NA 1.086 hours 1compartment NA NA Human Human +DTXSID1044932 Css NA 0.1652 mg/L 3compartmentss NA 50% Human Human +DTXSID1044932 Css NA 1.123 mg/L 3compartmentss NA 95% Human Human +DTXSID1044932 Css NA 0.1213 mg/L PBTK NA 50% Human Human +DTXSID1044932 Css NA 0.7399 mg/L PBTK NA 95% Human Human +DTXSID1044932 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044932 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044932 Vd NA 0.5363 L/kg 1compartment NA NA Rat Human DTXSID1044932 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044932 TK.Half.Life NA 1.67 hours 1compartment NA NA Rat Human -DTXSID1044932 Css NA 0.5798 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044932 Css NA 2.706 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044932 Css NA 0.3469 mg/L PBTK NA 50% Rat Human -DTXSID1044932 Css NA 1.513 mg/L PBTK NA 95% Rat Human -DTXSID1044934 Clint NA 1.742 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044934 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044934 Vd NA 0.7878 L/kg 1compartment NA NA Human Human +DTXSID1044932 TK.Half.Life NA 0.6233 hours 1compartment NA NA Rat Human +DTXSID1044932 Css NA 0.01952 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044932 Css NA 0.09754 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044932 Css NA 0.01425 mg/L PBTK NA 50% Rat Human +DTXSID1044932 Css NA 0.06207 mg/L PBTK NA 95% Rat Human +DTXSID1044934 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044934 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044934 Vd NA 0.667 L/kg 1compartment NA NA Human Human DTXSID1044934 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044934 TK.Half.Life NA 1.558 hours 1compartment NA NA Human Human -DTXSID1044934 Css NA 0.2196 mg/L 3compartmentss NA 50% Human Human -DTXSID1044934 Css NA 1.593 mg/L 3compartmentss NA 95% Human Human -DTXSID1044934 Css NA 0.1832 mg/L PBTK NA 50% Human Human -DTXSID1044934 Css NA 1.08 mg/L PBTK NA 95% Human Human -DTXSID1044934 Clint NA 1.742 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044934 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044934 Vd NA 0.824 L/kg 1compartment NA NA Rat Human +DTXSID1044934 TK.Half.Life NA 5.613 hours 1compartment NA NA Human Human +DTXSID1044934 Css NA 0.8723 mg/L 3compartmentss NA 50% Human Human +DTXSID1044934 Css NA 5.489 mg/L 3compartmentss NA 95% Human Human +DTXSID1044934 Css NA 0.707 mg/L PBTK NA 50% Human Human +DTXSID1044934 Css NA 3.513 mg/L PBTK NA 95% Human Human +DTXSID1044934 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044934 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044934 Vd NA 0.6978 L/kg 1compartment NA NA Rat Human DTXSID1044934 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044934 TK.Half.Life NA 0.8265 hours 1compartment NA NA Rat Human -DTXSID1044934 Css NA 0.08908 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044934 Css NA 0.5884 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044934 Css NA 0.07411 mg/L PBTK NA 50% Rat Human -DTXSID1044934 Css NA 0.3575 mg/L PBTK NA 95% Rat Human -DTXSID1044938 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1044934 TK.Half.Life NA 2.001 hours 1compartment NA NA Rat Human +DTXSID1044934 Css NA 0.01668 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044934 Css NA 0.1379 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044934 Css NA 0.0129 mg/L PBTK NA 50% Rat Human +DTXSID1044934 Css NA 0.0888 mg/L PBTK NA 95% Rat Human +DTXSID1044936 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044936 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044936 Vd NA 0.6968 L/kg 1compartment NA NA Human Human +DTXSID1044936 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1044936 TK.Half.Life NA 17.81 hours 1compartment NA NA Human Human +DTXSID1044936 Css NA 2.558 mg/L 3compartmentss NA 50% Human Human +DTXSID1044936 Css NA 10.16 mg/L 3compartmentss NA 95% Human Human +DTXSID1044936 Css NA 1.785 mg/L PBTK NA 50% Human Human +DTXSID1044936 Css NA 6.415 mg/L PBTK NA 95% Human Human +DTXSID1044936 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044936 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044936 Vd NA 0.6058 L/kg 1compartment NA NA Rat Human +DTXSID1044936 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1044936 TK.Half.Life NA 5.112 hours 1compartment NA NA Rat Human +DTXSID1044936 Css NA 0.06126 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044936 Css NA 0.3323 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044936 Css NA 0.04209 mg/L PBTK NA 50% Rat Human +DTXSID1044936 Css NA 0.2065 mg/L PBTK NA 95% Rat Human +DTXSID1044938 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1044938 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID1044938 Vd NA 1.61 L/kg 1compartment NA NA Human Human +DTXSID1044938 Vd NA 1.62 L/kg 1compartment NA NA Human Human DTXSID1044938 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1044938 TK.Half.Life NA 11.93 hours 1compartment NA NA Human Human -DTXSID1044938 Css NA 0.7498 mg/L 3compartmentss NA 50% Human Human -DTXSID1044938 Css NA 3.25 mg/L 3compartmentss NA 95% Human Human -DTXSID1044938 Css NA 0.728 mg/L PBTK NA 50% Human Human -DTXSID1044938 Css NA 2.467 mg/L PBTK NA 95% Human Human -DTXSID1044938 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1044938 TK.Half.Life NA 12.04 hours 1compartment NA NA Human Human +DTXSID1044938 Css NA 0.7316 mg/L 3compartmentss NA 50% Human Human +DTXSID1044938 Css NA 3.236 mg/L 3compartmentss NA 95% Human Human +DTXSID1044938 Css NA 0.7102 mg/L PBTK NA 50% Human Human +DTXSID1044938 Css NA 2.41 mg/L PBTK NA 95% Human Human +DTXSID1044938 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1044938 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID1044938 Vd NA 1.457 L/kg 1compartment NA NA Rat Human +DTXSID1044938 Vd NA 1.464 L/kg 1compartment NA NA Rat Human DTXSID1044938 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044938 TK.Half.Life NA 3.324 hours 1compartment NA NA Rat Human -DTXSID1044938 Css NA 0.1905 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044938 Css NA 0.7731 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044938 Css NA 0.183 mg/L PBTK NA 50% Rat Human -DTXSID1044938 Css NA 0.5297 mg/L PBTK NA 95% Rat Human -DTXSID1044980 Clint NA 5.456 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044980 Fup NA 0.7772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044980 Vd NA 2.212 L/kg 1compartment NA NA Human Human -DTXSID1044980 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044980 TK.Half.Life NA 2.671 hours 1compartment NA NA Human Human -DTXSID1044980 Css NA 0.08782 mg/L 3compartmentss NA 50% Human Human -DTXSID1044980 Css NA 0.7673 mg/L 3compartmentss NA 95% Human Human -DTXSID1044980 Css NA 0.0898 mg/L PBTK NA 50% Human Human -DTXSID1044980 Css NA 0.5621 mg/L PBTK NA 95% Human Human -DTXSID1044980 Clint NA 5.456 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044980 Fup NA 0.7772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044980 Vd NA 2.245 L/kg 1compartment NA NA Rat Human +DTXSID1044938 TK.Half.Life NA 3.342 hours 1compartment NA NA Rat Human +DTXSID1044938 Css NA 0.043 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044938 Css NA 0.1776 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044938 Css NA 0.04281 mg/L PBTK NA 50% Rat Human +DTXSID1044938 Css NA 0.1257 mg/L PBTK NA 95% Rat Human +DTXSID1044980 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044980 Fup 0.595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044980 Vd NA 1.916 L/kg 1compartment NA NA Human Human +DTXSID1044980 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1044980 TK.Half.Life NA 20.83 hours 1compartment NA NA Human Human +DTXSID1044980 Css NA 0.966 mg/L 3compartmentss NA 50% Human Human +DTXSID1044980 Css NA 7.721 mg/L 3compartmentss NA 95% Human Human +DTXSID1044980 Css NA 0.9556 mg/L PBTK NA 50% Human Human +DTXSID1044980 Css NA 5.131 mg/L PBTK NA 95% Human Human +DTXSID1044980 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044980 Fup 0.595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044980 Vd NA 1.938 L/kg 1compartment NA NA Rat Human DTXSID1044980 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044980 TK.Half.Life NA 1.483 hours 1compartment NA NA Rat Human -DTXSID1044980 Css NA 0.04003 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044980 Css NA 0.3287 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044980 Css NA 0.04146 mg/L PBTK NA 50% Rat Human -DTXSID1044980 Css NA 0.2254 mg/L PBTK NA 95% Rat Human -DTXSID1044982 Clint NA 11.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044982 Fup NA 0.1181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044982 Vd NA 0.5326 L/kg 1compartment NA NA Human Human +DTXSID1044980 TK.Half.Life NA 7.18 hours 1compartment NA NA Rat Human +DTXSID1044980 Css NA 0.05879 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044980 Css NA 0.4464 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044980 Css NA 0.05856 mg/L PBTK NA 50% Rat Human +DTXSID1044980 Css NA 0.2894 mg/L PBTK NA 95% Rat Human +DTXSID1044982 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044982 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044982 Vd NA 0.79 L/kg 1compartment NA NA Human Human DTXSID1044982 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1044982 TK.Half.Life NA 1.908 hours 1compartment NA NA Human Human -DTXSID1044982 Css NA 0.4572 mg/L 3compartmentss NA 50% Human Human -DTXSID1044982 Css NA 3.371 mg/L 3compartmentss NA 95% Human Human -DTXSID1044982 Css NA 0.2922 mg/L PBTK NA 50% Human Human -DTXSID1044982 Css NA 2.059 mg/L PBTK NA 95% Human Human -DTXSID1044982 Clint NA 11.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044982 Fup NA 0.1181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044982 Vd NA 0.4662 L/kg 1compartment NA NA Rat Human +DTXSID1044982 TK.Half.Life NA 1.135 hours 1compartment NA NA Human Human +DTXSID1044982 Css NA 0.08188 mg/L 3compartmentss NA 50% Human Human +DTXSID1044982 Css NA 0.6106 mg/L 3compartmentss NA 95% Human Human +DTXSID1044982 Css NA 0.0581 mg/L PBTK NA 50% Human Human +DTXSID1044982 Css NA 0.4071 mg/L PBTK NA 95% Human Human +DTXSID1044982 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044982 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044982 Vd NA 0.6954 L/kg 1compartment NA NA Rat Human DTXSID1044982 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044982 TK.Half.Life NA 0.9983 hours 1compartment NA NA Rat Human -DTXSID1044982 Css NA 0.2482 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044982 Css NA 1.374 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044982 Css NA 0.1485 mg/L PBTK NA 50% Rat Human -DTXSID1044982 Css NA 0.7714 mg/L PBTK NA 95% Rat Human -DTXSID1044986 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044986 Fup NA 0.7413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1044986 Vd NA 1.184 L/kg 1compartment NA NA Human Human -DTXSID1044986 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1044986 TK.Half.Life NA 10.98 hours 1compartment NA NA Human Human -DTXSID1044986 Css NA 0.9846 mg/L 3compartmentss NA 50% Human Human -DTXSID1044986 Css NA 6.555 mg/L 3compartmentss NA 95% Human Human -DTXSID1044986 Css NA 0.8731 mg/L PBTK NA 50% Human Human -DTXSID1044986 Css NA 4.332 mg/L PBTK NA 95% Human Human -DTXSID1044986 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044986 Fup NA 0.7413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1044986 Vd NA 1.099 L/kg 1compartment NA NA Rat Human +DTXSID1044982 TK.Half.Life NA 0.5324 hours 1compartment NA NA Rat Human +DTXSID1044982 Css NA 0.01046 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044982 Css NA 0.05585 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044982 Css NA 0.007352 mg/L PBTK NA 50% Rat Human +DTXSID1044982 Css NA 0.03602 mg/L PBTK NA 95% Rat Human +DTXSID1044986 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044986 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1044986 Vd NA 1.572 L/kg 1compartment NA NA Human Human +DTXSID1044986 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1044986 TK.Half.Life NA 1.561 hours 1compartment NA NA Human Human +DTXSID1044986 Css NA 0.03983 mg/L 3compartmentss NA 50% Human Human +DTXSID1044986 Css NA 0.3656 mg/L 3compartmentss NA 95% Human Human +DTXSID1044986 Css NA 0.03348 mg/L PBTK NA 50% Human Human +DTXSID1044986 Css NA 0.2645 mg/L PBTK NA 95% Human Human +DTXSID1044986 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044986 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1044986 Vd NA 1.324 L/kg 1compartment NA NA Rat Human DTXSID1044986 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1044986 TK.Half.Life NA 3.316 hours 1compartment NA NA Rat Human -DTXSID1044986 Css NA 0.2564 mg/L 3compartmentss NA 50% Rat Human -DTXSID1044986 Css NA 1.676 mg/L 3compartmentss NA 95% Rat Human -DTXSID1044986 Css NA 0.2211 mg/L PBTK NA 50% Rat Human -DTXSID1044986 Css NA 1.021 mg/L PBTK NA 95% Rat Human -DTXSID1045033 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1044986 TK.Half.Life NA 0.6267 hours 1compartment NA NA Rat Human +DTXSID1044986 Css NA 0.004988 mg/L 3compartmentss NA 50% Rat Human +DTXSID1044986 Css NA 0.03716 mg/L 3compartmentss NA 95% Rat Human +DTXSID1044986 Css NA 0.00423 mg/L PBTK NA 50% Rat Human +DTXSID1044986 Css NA 0.02641 mg/L PBTK NA 95% Rat Human +DTXSID1045033 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1045033 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1045033 Vd NA 0.1651 L/kg 1compartment NA NA Human Human DTXSID1045033 Days.Css NA 50 Days PBTK NA NA Human Human DTXSID1045033 TK.Half.Life NA 213.6 hours 1compartment NA NA Human Human -DTXSID1045033 Css NA 228.8 mg/L 3compartmentss NA 50% Human Human -DTXSID1045033 Css NA 1397 mg/L 3compartmentss NA 95% Human Human -DTXSID1045033 Css NA 132.6 mg/L PBTK NA 50% Human Human -DTXSID1045033 Css NA 794.4 mg/L PBTK NA 95% Human Human -DTXSID1045033 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1045033 Css NA 120.1 mg/L 3compartmentss NA 50% Human Human +DTXSID1045033 Css NA 775.6 mg/L 3compartmentss NA 95% Human Human +DTXSID1045033 Css NA 69.76 mg/L PBTK NA 50% Human Human +DTXSID1045033 Css NA 450.3 mg/L PBTK NA 95% Human Human +DTXSID1045033 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1045033 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1045033 Vd NA 0.1633 L/kg 1compartment NA NA Rat Human DTXSID1045033 Days.Css NA 14 Days PBTK NA NA Rat Human DTXSID1045033 TK.Half.Life NA 72.01 hours 1compartment NA NA Rat Human -DTXSID1045033 Css NA 64.59 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045033 Css NA 338.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045033 Css NA 34.96 mg/L PBTK NA 50% Rat Human -DTXSID1045033 Css NA 182.7 mg/L PBTK NA 95% Rat Human -DTXSID1045081 Clint NA 7.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045081 Fup NA 0.2366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045081 Vd NA 1.225 L/kg 1compartment NA NA Human Human +DTXSID1045033 Css NA 0.678 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045033 Css NA 4.3 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045033 Css NA 0.3678 mg/L PBTK NA 50% Rat Human +DTXSID1045033 Css NA 2.335 mg/L PBTK NA 95% Rat Human +DTXSID1045081 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045081 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045081 Vd NA 0.5434 L/kg 1compartment NA NA Human Human DTXSID1045081 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045081 TK.Half.Life NA 3.595 hours 1compartment NA NA Human Human -DTXSID1045081 Css NA 0.2716 mg/L 3compartmentss NA 50% Human Human -DTXSID1045081 Css NA 1.631 mg/L 3compartmentss NA 95% Human Human -DTXSID1045081 Css NA 0.198 mg/L PBTK NA 50% Human Human -DTXSID1045081 Css NA 1.11 mg/L PBTK NA 95% Human Human -DTXSID1045081 Clint NA 7.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045081 Fup NA 0.2366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045081 Vd NA 0.9998 L/kg 1compartment NA NA Rat Human +DTXSID1045081 TK.Half.Life NA 8.469 hours 1compartment NA NA Human Human +DTXSID1045081 Css NA 1.719 mg/L 3compartmentss NA 50% Human Human +DTXSID1045081 Css NA 7.501 mg/L 3compartmentss NA 95% Human Human +DTXSID1045081 Css NA 1.261 mg/L PBTK NA 50% Human Human +DTXSID1045081 Css NA 4.705 mg/L PBTK NA 95% Human Human +DTXSID1045081 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045081 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045081 Vd NA 0.5515 L/kg 1compartment NA NA Rat Human DTXSID1045081 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045081 TK.Half.Life NA 1.564 hours 1compartment NA NA Rat Human -DTXSID1045081 Css NA 0.1441 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045081 Css NA 0.6192 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045081 Css NA 0.09996 mg/L PBTK NA 50% Rat Human -DTXSID1045081 Css NA 0.396 mg/L PBTK NA 95% Rat Human -DTXSID1045083 Clint NA 2.376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045083 Fup NA 0.1132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045083 Vd NA 3.706 L/kg 1compartment NA NA Human Human -DTXSID1045083 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1045083 TK.Half.Life NA 31.96 hours 1compartment NA NA Human Human -DTXSID1045083 Css NA 0.8652 mg/L 3compartmentss NA 50% Human Human -DTXSID1045083 Css NA 5.545 mg/L 3compartmentss NA 95% Human Human -DTXSID1045083 Css NA 0.816 mg/L PBTK NA 50% Human Human -DTXSID1045083 Css NA 4.473 mg/L PBTK NA 95% Human Human -DTXSID1045083 Clint NA 2.376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045083 Fup NA 0.1132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045083 Vd NA 3.398 L/kg 1compartment NA NA Rat Human -DTXSID1045083 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1045083 TK.Half.Life NA 12.5 hours 1compartment NA NA Rat Human -DTXSID1045083 Css NA 0.4343 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045083 Css NA 2.202 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045083 Css NA 0.4011 mg/L PBTK NA 50% Rat Human -DTXSID1045083 Css NA 1.591 mg/L PBTK NA 95% Rat Human -DTXSID1045085 Clint NA 68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045085 Fup NA 0.0159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045085 Vd NA 2.986 L/kg 1compartment NA NA Human Human -DTXSID1045085 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1045085 TK.Half.Life NA 22.03 hours 1compartment NA NA Human Human -DTXSID1045085 Css NA 0.877 mg/L 3compartmentss NA 50% Human Human -DTXSID1045085 Css NA 5.683 mg/L 3compartmentss NA 95% Human Human -DTXSID1045085 Css NA 0.6 mg/L PBTK NA 50% Human Human -DTXSID1045085 Css NA 3.822 mg/L PBTK NA 95% Human Human -DTXSID1045085 Clint NA 68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045085 Fup NA 0.0159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045085 Vd NA 2.235 L/kg 1compartment NA NA Rat Human +DTXSID1045081 TK.Half.Life NA 2.925 hours 1compartment NA NA Rat Human +DTXSID1045081 Css NA 0.1092 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045081 Css NA 0.3991 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045081 Css NA 0.07928 mg/L PBTK NA 50% Rat Human +DTXSID1045081 Css NA 0.2449 mg/L PBTK NA 95% Rat Human +DTXSID1045083 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045083 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045083 Vd NA 0.8384 L/kg 1compartment NA NA Human Human +DTXSID1045083 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045083 TK.Half.Life NA 4.423 hours 1compartment NA NA Human Human +DTXSID1045083 Css NA 0.576 mg/L 3compartmentss NA 50% Human Human +DTXSID1045083 Css NA 4.526 mg/L 3compartmentss NA 95% Human Human +DTXSID1045083 Css NA 0.3915 mg/L PBTK NA 50% Human Human +DTXSID1045083 Css NA 2.822 mg/L PBTK NA 95% Human Human +DTXSID1045083 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045083 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045083 Vd NA 0.8304 L/kg 1compartment NA NA Rat Human +DTXSID1045083 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1045083 TK.Half.Life NA 2.659 hours 1compartment NA NA Rat Human +DTXSID1045083 Css NA 0.02622 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045083 Css NA 0.221 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045083 Css NA 0.01731 mg/L PBTK NA 50% Rat Human +DTXSID1045083 Css NA 0.133 mg/L PBTK NA 95% Rat Human +DTXSID1045085 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045085 Fup 0.0587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045085 Vd NA 2.918 L/kg 1compartment NA NA Human Human +DTXSID1045085 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1045085 TK.Half.Life NA 26.06 hours 1compartment NA NA Human Human +DTXSID1045085 Css NA 1.062 mg/L 3compartmentss NA 50% Human Human +DTXSID1045085 Css NA 6.64 mg/L 3compartmentss NA 95% Human Human +DTXSID1045085 Css NA 0.7411 mg/L PBTK NA 50% Human Human +DTXSID1045085 Css NA 4.502 mg/L PBTK NA 95% Human Human +DTXSID1045085 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045085 Fup 0.0587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045085 Vd NA 2.223 L/kg 1compartment NA NA Rat Human DTXSID1045085 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1045085 TK.Half.Life NA 3.836 hours 1compartment NA NA Rat Human -DTXSID1045085 Css NA 0.4913 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045085 Css NA 2.608 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045085 Css NA 0.3212 mg/L PBTK NA 50% Rat Human -DTXSID1045085 Css NA 1.654 mg/L PBTK NA 95% Rat Human +DTXSID1045085 TK.Half.Life NA 5.299 hours 1compartment NA NA Rat Human +DTXSID1045085 Css NA 0.1359 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045085 Css NA 0.7521 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045085 Css NA 0.0939 mg/L PBTK NA 50% Rat Human +DTXSID1045085 Css NA 0.4999 mg/L PBTK NA 95% Rat Human DTXSID1045089 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1045089 Fup NA 0.1658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1045089 Vd NA 0.3211 L/kg 1compartment NA NA Human Human DTXSID1045089 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID1045089 TK.Half.Life NA 12.53 hours 1compartment NA NA Human Human -DTXSID1045089 Css NA 4.974 mg/L 3compartmentss NA 50% Human Human -DTXSID1045089 Css NA 17.91 mg/L 3compartmentss NA 95% Human Human -DTXSID1045089 Css NA 3.224 mg/L PBTK NA 50% Human Human -DTXSID1045089 Css NA 10.73 mg/L PBTK NA 95% Human Human +DTXSID1045089 Css NA 4.827 mg/L 3compartmentss NA 50% Human Human +DTXSID1045089 Css NA 17.39 mg/L 3compartmentss NA 95% Human Human +DTXSID1045089 Css NA 3.098 mg/L PBTK NA 50% Human Human +DTXSID1045089 Css NA 10.48 mg/L PBTK NA 95% Human Human DTXSID1045089 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1045089 Fup NA 0.1658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1045089 Vd NA 0.325 L/kg 1compartment NA NA Rat Human DTXSID1045089 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1045089 TK.Half.Life NA 4.321 hours 1compartment NA NA Rat Human -DTXSID1045089 Css NA 1.396 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045089 Css NA 4.106 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045089 Css NA 0.8456 mg/L PBTK NA 50% Rat Human -DTXSID1045089 Css NA 2.316 mg/L PBTK NA 95% Rat Human -DTXSID1045110 Clint NA 9.111 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045110 Fup NA 0.042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045110 Vd NA 3.109 L/kg 1compartment NA NA Human Human -DTXSID1045110 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID1045110 TK.Half.Life NA 172.9 hours 1compartment NA NA Human Human -DTXSID1045110 Css NA 6.904 mg/L 3compartmentss NA 50% Human Human -DTXSID1045110 Css NA 43.11 mg/L 3compartmentss NA 95% Human Human -DTXSID1045110 Css NA 4.78 mg/L PBTK NA 50% Human Human -DTXSID1045110 Css NA 28.57 mg/L PBTK NA 95% Human Human -DTXSID1045110 Clint NA 9.111 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045110 Fup NA 0.042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045110 Vd NA 2.329 L/kg 1compartment NA NA Rat Human -DTXSID1045110 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID1045110 TK.Half.Life NA 23.11 hours 1compartment NA NA Rat Human -DTXSID1045110 Css NA 3.854 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045110 Css NA 20.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045110 Css NA 2.56 mg/L PBTK NA 50% Rat Human -DTXSID1045110 Css NA 13.45 mg/L PBTK NA 95% Rat Human -DTXSID1045112 Clint NA 45.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045112 Fup NA 0.5222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045112 Vd NA 1.733 L/kg 1compartment NA NA Human Human +DTXSID1045089 Css NA 0.3134 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045089 Css NA 0.9322 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045089 Css NA 0.1968 mg/L PBTK NA 50% Rat Human +DTXSID1045089 Css NA 0.5446 mg/L PBTK NA 95% Rat Human +DTXSID1045110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045110 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045110 Vd NA 3.128 L/kg 1compartment NA NA Human Human +DTXSID1045110 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID1045110 TK.Half.Life NA 64 hours 1compartment NA NA Human Human +DTXSID1045110 Css NA 2.343 mg/L 3compartmentss NA 50% Human Human +DTXSID1045110 Css NA 15.51 mg/L 3compartmentss NA 95% Human Human +DTXSID1045110 Css NA 1.632 mg/L PBTK NA 50% Human Human +DTXSID1045110 Css NA 10.28 mg/L PBTK NA 95% Human Human +DTXSID1045110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045110 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045110 Vd NA 2.347 L/kg 1compartment NA NA Rat Human +DTXSID1045110 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID1045110 TK.Half.Life NA 8.761 hours 1compartment NA NA Rat Human +DTXSID1045110 Css NA 0.3051 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045110 Css NA 1.746 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045110 Css NA 0.211 mg/L PBTK NA 50% Rat Human +DTXSID1045110 Css NA 1.194 mg/L PBTK NA 95% Rat Human +DTXSID1045112 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045112 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045112 Vd NA 0.6292 L/kg 1compartment NA NA Human Human DTXSID1045112 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045112 TK.Half.Life NA 1.171 hours 1compartment NA NA Human Human -DTXSID1045112 Css NA 0.01515 mg/L 3compartmentss NA 50% Human Human -DTXSID1045112 Css NA 0.1597 mg/L 3compartmentss NA 95% Human Human -DTXSID1045112 Css NA 0.01468 mg/L PBTK NA 50% Human Human -DTXSID1045112 Css NA 0.1278 mg/L PBTK NA 95% Human Human -DTXSID1045112 Clint NA 45.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045112 Fup NA 0.5222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045112 Vd NA 1.702 L/kg 1compartment NA NA Rat Human +DTXSID1045112 TK.Half.Life NA 7.169 hours 1compartment NA NA Human Human +DTXSID1045112 Css NA 1.28 mg/L 3compartmentss NA 50% Human Human +DTXSID1045112 Css NA 8.844 mg/L 3compartmentss NA 95% Human Human +DTXSID1045112 Css NA 0.9992 mg/L PBTK NA 50% Human Human +DTXSID1045112 Css NA 5.538 mg/L PBTK NA 95% Human Human +DTXSID1045112 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045112 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045112 Vd NA 0.6434 L/kg 1compartment NA NA Rat Human DTXSID1045112 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045112 TK.Half.Life NA 0.5576 hours 1compartment NA NA Rat Human -DTXSID1045112 Css NA 0.007812 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045112 Css NA 0.07252 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045112 Css NA 0.00756 mg/L PBTK NA 50% Rat Human -DTXSID1045112 Css NA 0.05358 mg/L PBTK NA 95% Rat Human -DTXSID1045114 Clint NA 2.852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045114 Fup NA 0.1062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045114 Vd NA 0.376 L/kg 1compartment NA NA Human Human +DTXSID1045112 TK.Half.Life NA 2.494 hours 1compartment NA NA Rat Human +DTXSID1045112 Css NA 0.07808 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045112 Css NA 0.4955 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045112 Css NA 0.06045 mg/L PBTK NA 50% Rat Human +DTXSID1045112 Css NA 0.2987 mg/L PBTK NA 95% Rat Human +DTXSID1045114 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045114 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045114 Vd NA 0.4352 L/kg 1compartment NA NA Human Human DTXSID1045114 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045114 TK.Half.Life NA 4.209 hours 1compartment NA NA Human Human -DTXSID1045114 Css NA 1.736 mg/L 3compartmentss NA 50% Human Human -DTXSID1045114 Css NA 10.16 mg/L 3compartmentss NA 95% Human Human -DTXSID1045114 Css NA 1.082 mg/L PBTK NA 50% Human Human -DTXSID1045114 Css NA 6.021 mg/L PBTK NA 95% Human Human -DTXSID1045114 Clint NA 2.852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045114 Fup NA 0.1062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045114 Vd NA 0.3512 L/kg 1compartment NA NA Rat Human +DTXSID1045114 TK.Half.Life NA 2.018 hours 1compartment NA NA Human Human +DTXSID1045114 Css NA 0.3106 mg/L 3compartmentss NA 50% Human Human +DTXSID1045114 Css NA 2.362 mg/L 3compartmentss NA 95% Human Human +DTXSID1045114 Css NA 0.1985 mg/L PBTK NA 50% Human Human +DTXSID1045114 Css NA 1.445 mg/L PBTK NA 95% Human Human +DTXSID1045114 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045114 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045114 Vd NA 0.4065 L/kg 1compartment NA NA Rat Human DTXSID1045114 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045114 TK.Half.Life NA 2.264 hours 1compartment NA NA Rat Human -DTXSID1045114 Css NA 0.848 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045114 Css NA 3.888 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045114 Css NA 0.4948 mg/L PBTK NA 50% Rat Human -DTXSID1045114 Css NA 2.155 mg/L PBTK NA 95% Rat Human +DTXSID1045114 TK.Half.Life NA 1.124 hours 1compartment NA NA Rat Human +DTXSID1045114 Css NA 0.003154 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045114 Css NA 0.02049 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045114 Css NA 0.001906 mg/L PBTK NA 50% Rat Human +DTXSID1045114 Css NA 0.01171 mg/L PBTK NA 95% Rat Human DTXSID1045116 Clint 19.08 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1045116 Fup 0.082 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1045116 Vd NA 1.729 L/kg 1compartment NA NA Human Human DTXSID1045116 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1045116 TK.Half.Life NA 6.515 hours 1compartment NA NA Human Human -DTXSID1045116 Css NA 0.4695 mg/L 3compartmentss NA 50% Human Human -DTXSID1045116 Css NA 3.354 mg/L 3compartmentss NA 95% Human Human -DTXSID1045116 Css NA 0.3151 mg/L PBTK NA 50% Human Human -DTXSID1045116 Css NA 2.205 mg/L PBTK NA 95% Human Human +DTXSID1045116 Css NA 0.41 mg/L 3compartmentss NA 50% Human Human +DTXSID1045116 Css NA 2.845 mg/L 3compartmentss NA 95% Human Human +DTXSID1045116 Css NA 0.3031 mg/L PBTK NA 50% Human Human +DTXSID1045116 Css NA 2.105 mg/L PBTK NA 95% Human Human DTXSID1045116 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID1045116 Fup 0.09 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID1045116 Vd NA 1.353 L/kg 1compartment NA NA Rat Rat DTXSID1045116 Days.Css NA 10 Days PBTK NA NA Rat Rat DTXSID1045116 TK.Half.Life NA 38.3 hours 1compartment NA NA Rat Rat -DTXSID1045116 Css NA 4.549 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1045116 Css NA 14.72 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1045116 Css NA 2.892 mg/L PBTK NA 50% Rat Rat -DTXSID1045116 Css NA 8.432 mg/L PBTK NA 95% Rat Rat +DTXSID1045116 Css NA 0.8822 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1045116 Css NA 2.526 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1045116 Css NA 0.676 mg/L PBTK NA 50% Rat Rat +DTXSID1045116 Css NA 1.934 mg/L PBTK NA 95% Rat Rat DTXSID1045118 Clint 4.673 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1045118 Fup 0.00039 NA NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1045118 Vd NA 0.2239 L/kg 1compartment NA NA Human Human DTXSID1045118 Days.Css NA 81 Days PBTK NA NA Human Human DTXSID1045118 TK.Half.Life NA 325.9 hours 1compartment NA NA Human Human -DTXSID1045118 Css NA 273.6 mg/L 3compartmentss NA 50% Human Human -DTXSID1045118 Css NA 1622 mg/L 3compartmentss NA 95% Human Human -DTXSID1045118 Css NA 155.9 mg/L PBTK NA 50% Human Human -DTXSID1045118 Css NA 911.7 mg/L PBTK NA 95% Human Human +DTXSID1045118 Css NA 278.4 mg/L 3compartmentss NA 50% Human Human +DTXSID1045118 Css NA 1647 mg/L 3compartmentss NA 95% Human Human +DTXSID1045118 Css NA 153.1 mg/L PBTK NA 50% Human Human +DTXSID1045118 Css NA 905.7 mg/L PBTK NA 95% Human Human DTXSID1045118 Clint 4.673 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID1045118 Fup 0.00039 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID1045118 Vd NA 0.1926 L/kg 1compartment NA NA Rat Human DTXSID1045118 Days.Css NA 42 Days PBTK NA NA Rat Human DTXSID1045118 TK.Half.Life NA 179.6 hours 1compartment NA NA Rat Human -DTXSID1045118 Css NA 152.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045118 Css NA 578.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045118 Css NA 80.88 mg/L PBTK NA 50% Rat Human -DTXSID1045118 Css NA 310 mg/L PBTK NA 95% Rat Human -DTXSID1045160 Clint NA 7.269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045160 Fup NA 0.2972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045160 Vd NA 0.6595 L/kg 1compartment NA NA Human Human +DTXSID1045118 Css NA 33.14 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045118 Css NA 133.2 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045118 Css NA 18.88 mg/L PBTK NA 50% Rat Human +DTXSID1045118 Css NA 75.91 mg/L PBTK NA 95% Rat Human +DTXSID1045160 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045160 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045160 Vd NA 0.7569 L/kg 1compartment NA NA Human Human DTXSID1045160 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045160 TK.Half.Life NA 1.538 hours 1compartment NA NA Human Human -DTXSID1045160 Css NA 0.2051 mg/L 3compartmentss NA 50% Human Human -DTXSID1045160 Css NA 1.286 mg/L 3compartmentss NA 95% Human Human -DTXSID1045160 Css NA 0.1468 mg/L PBTK NA 50% Human Human -DTXSID1045160 Css NA 0.8464 mg/L PBTK NA 95% Human Human -DTXSID1045160 Clint NA 7.269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045160 Fup NA 0.2972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045160 Vd NA 0.6149 L/kg 1compartment NA NA Rat Human +DTXSID1045160 TK.Half.Life NA 1.605 hours 1compartment NA NA Human Human +DTXSID1045160 Css NA 0.17 mg/L 3compartmentss NA 50% Human Human +DTXSID1045160 Css NA 1.147 mg/L 3compartmentss NA 95% Human Human +DTXSID1045160 Css NA 0.1284 mg/L PBTK NA 50% Human Human +DTXSID1045160 Css NA 0.7572 mg/L PBTK NA 95% Human Human +DTXSID1045160 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045160 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045160 Vd NA 0.707 L/kg 1compartment NA NA Rat Human DTXSID1045160 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045160 TK.Half.Life NA 0.8108 hours 1compartment NA NA Rat Human -DTXSID1045160 Css NA 0.1051 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045160 Css NA 0.4997 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045160 Css NA 0.07214 mg/L PBTK NA 50% Rat Human -DTXSID1045160 Css NA 0.3056 mg/L PBTK NA 95% Rat Human -DTXSID1045162 Clint NA 33.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045162 Fup NA 0.1903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045162 Vd NA 2.097 L/kg 1compartment NA NA Human Human +DTXSID1045160 TK.Half.Life NA 0.8329 hours 1compartment NA NA Rat Human +DTXSID1045160 Css NA 0.0197 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045160 Css NA 0.09713 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045160 Css NA 0.01484 mg/L PBTK NA 50% Rat Human +DTXSID1045160 Css NA 0.06333 mg/L PBTK NA 95% Rat Human +DTXSID1045162 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045162 Fup 0.218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045162 Vd NA 2.292 L/kg 1compartment NA NA Human Human DTXSID1045162 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045162 TK.Half.Life NA 2.471 hours 1compartment NA NA Human Human -DTXSID1045162 Css NA 0.05758 mg/L 3compartmentss NA 50% Human Human -DTXSID1045162 Css NA 0.4396 mg/L 3compartmentss NA 95% Human Human -DTXSID1045162 Css NA 0.05 mg/L PBTK NA 50% Human Human -DTXSID1045162 Css NA 0.3396 mg/L PBTK NA 95% Human Human -DTXSID1045162 Clint NA 33.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045162 Fup NA 0.1903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045162 Vd NA 2.061 L/kg 1compartment NA NA Rat Human +DTXSID1045162 TK.Half.Life NA 6.943 hours 1compartment NA NA Human Human +DTXSID1045162 Css NA 0.2366 mg/L 3compartmentss NA 50% Human Human +DTXSID1045162 Css NA 1.485 mg/L 3compartmentss NA 95% Human Human +DTXSID1045162 Css NA 0.2141 mg/L PBTK NA 50% Human Human +DTXSID1045162 Css NA 1.165 mg/L PBTK NA 95% Human Human +DTXSID1045162 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045162 Fup 0.218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045162 Vd NA 2.257 L/kg 1compartment NA NA Rat Human DTXSID1045162 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045162 TK.Half.Life NA 1.307 hours 1compartment NA NA Rat Human -DTXSID1045162 Css NA 0.03132 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045162 Css NA 0.1829 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045162 Css NA 0.02634 mg/L PBTK NA 50% Rat Human -DTXSID1045162 Css NA 0.1366 mg/L PBTK NA 95% Rat Human -DTXSID1045164 Clint NA 0.5527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045164 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045164 Vd NA 0.2746 L/kg 1compartment NA NA Human Human -DTXSID1045164 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1045164 TK.Half.Life NA 18.11 hours 1compartment NA NA Human Human -DTXSID1045164 Css NA 10.77 mg/L 3compartmentss NA 50% Human Human -DTXSID1045164 Css NA 56.47 mg/L 3compartmentss NA 95% Human Human -DTXSID1045164 Css NA 6.602 mg/L PBTK NA 50% Human Human -DTXSID1045164 Css NA 32.95 mg/L PBTK NA 95% Human Human -DTXSID1045164 Clint NA 0.5527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045164 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045164 Vd NA 0.2651 L/kg 1compartment NA NA Rat Human +DTXSID1045162 TK.Half.Life NA 3.947 hours 1compartment NA NA Rat Human +DTXSID1045162 Css NA 0.02732 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045162 Css NA 0.135 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045162 Css NA 0.02512 mg/L PBTK NA 50% Rat Human +DTXSID1045162 Css NA 0.1002 mg/L PBTK NA 95% Rat Human +DTXSID1045164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045164 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045164 Vd NA 0.3401 L/kg 1compartment NA NA Human Human +DTXSID1045164 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045164 TK.Half.Life NA 0.6756 hours 1compartment NA NA Human Human +DTXSID1045164 Css NA 0.1726 mg/L 3compartmentss NA 50% Human Human +DTXSID1045164 Css NA 1.388 mg/L 3compartmentss NA 95% Human Human +DTXSID1045164 Css NA 0.1112 mg/L PBTK NA 50% Human Human +DTXSID1045164 Css NA 0.8504 mg/L PBTK NA 95% Human Human +DTXSID1045164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045164 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045164 Vd NA 0.3355 L/kg 1compartment NA NA Rat Human DTXSID1045164 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045164 TK.Half.Life NA 7.89 hours 1compartment NA NA Rat Human -DTXSID1045164 Css NA 4.133 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045164 Css NA 18.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045164 Css NA 2.354 mg/L PBTK NA 50% Rat Human -DTXSID1045164 Css NA 10.15 mg/L PBTK NA 95% Rat Human +DTXSID1045164 TK.Half.Life NA 0.3806 hours 1compartment NA NA Rat Human +DTXSID1045164 Css NA 0.02235 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045164 Css NA 0.1429 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045164 Css NA 0.01404 mg/L PBTK NA 50% Rat Human +DTXSID1045164 Css NA 0.08577 mg/L PBTK NA 95% Rat Human DTXSID1045166 Clint 5.062 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1045166 Fup 0.296 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Human Human DTXSID1045166 Vd NA 1.782 L/kg 1compartment NA NA Human Human DTXSID1045166 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1045166 TK.Half.Life NA 6.371 hours 1compartment NA NA Human Human -DTXSID1045166 Css NA 0.2806 mg/L 3compartmentss NA 50% Human Human -DTXSID1045166 Css NA 1.587 mg/L 3compartmentss NA 95% Human Human -DTXSID1045166 Css NA 0.2148 mg/L PBTK NA 50% Human Human -DTXSID1045166 Css NA 1.091 mg/L PBTK NA 95% Human Human +DTXSID1045166 Css NA 0.3112 mg/L 3compartmentss NA 50% Human Human +DTXSID1045166 Css NA 1.633 mg/L 3compartmentss NA 95% Human Human +DTXSID1045166 Css NA 0.2608 mg/L PBTK NA 50% Human Human +DTXSID1045166 Css NA 1.369 mg/L PBTK NA 95% Human Human DTXSID1045166 Clint 5.062 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID1045166 Fup 0.296 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Rat Human DTXSID1045166 Vd NA 1.596 L/kg 1compartment NA NA Rat Human DTXSID1045166 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1045166 TK.Half.Life NA 2.104 hours 1compartment NA NA Rat Human -DTXSID1045166 Css NA 0.1529 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045166 Css NA 0.6138 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045166 Css NA 0.1102 mg/L PBTK NA 50% Rat Human -DTXSID1045166 Css NA 0.3879 mg/L PBTK NA 95% Rat Human -DTXSID1045168 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045168 Fup NA 0.154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045168 Vd NA 0.6806 L/kg 1compartment NA NA Human Human -DTXSID1045168 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1045168 TK.Half.Life NA 29.83 hours 1compartment NA NA Human Human -DTXSID1045168 Css NA 5.949 mg/L 3compartmentss NA 50% Human Human -DTXSID1045168 Css NA 25.85 mg/L 3compartmentss NA 95% Human Human -DTXSID1045168 Css NA 3.939 mg/L PBTK NA 50% Human Human -DTXSID1045168 Css NA 15.66 mg/L PBTK NA 95% Human Human -DTXSID1045168 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045168 Fup NA 0.154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045168 Vd NA 0.5839 L/kg 1compartment NA NA Rat Human +DTXSID1045166 Css NA 0.02951 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045166 Css NA 0.1066 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045166 Css NA 0.02568 mg/L PBTK NA 50% Rat Human +DTXSID1045166 Css NA 0.09271 mg/L PBTK NA 95% Rat Human +DTXSID1045168 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045168 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045168 Vd NA 1.036 L/kg 1compartment NA NA Human Human +DTXSID1045168 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045168 TK.Half.Life NA 2.424 hours 1compartment NA NA Human Human +DTXSID1045168 Css NA 0.1662 mg/L 3compartmentss NA 50% Human Human +DTXSID1045168 Css NA 1.08 mg/L 3compartmentss NA 95% Human Human +DTXSID1045168 Css NA 0.126 mg/L PBTK NA 50% Human Human +DTXSID1045168 Css NA 0.7338 mg/L PBTK NA 95% Human Human +DTXSID1045168 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045168 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045168 Vd NA 0.8976 L/kg 1compartment NA NA Rat Human DTXSID1045168 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045168 TK.Half.Life NA 8.448 hours 1compartment NA NA Rat Human -DTXSID1045168 Css NA 1.662 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045168 Css NA 6.087 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045168 Css NA 1.035 mg/L PBTK NA 50% Rat Human -DTXSID1045168 Css NA 3.439 mg/L PBTK NA 95% Rat Human -DTXSID1045245 Clint NA 3.236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045245 Fup NA 0.2011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045245 Vd NA 1.645 L/kg 1compartment NA NA Human Human +DTXSID1045168 TK.Half.Life NA 1.141 hours 1compartment NA NA Rat Human +DTXSID1045168 Css NA 0.007371 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045168 Css NA 0.05431 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045168 Css NA 0.005564 mg/L PBTK NA 50% Rat Human +DTXSID1045168 Css NA 0.03657 mg/L PBTK NA 95% Rat Human +DTXSID1045245 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045245 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045245 Vd NA 1.362 L/kg 1compartment NA NA Human Human DTXSID1045245 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045245 TK.Half.Life NA 11.58 hours 1compartment NA NA Human Human -DTXSID1045245 Css NA 0.778 mg/L 3compartmentss NA 50% Human Human -DTXSID1045245 Css NA 3.649 mg/L 3compartmentss NA 95% Human Human -DTXSID1045245 Css NA 0.5602 mg/L PBTK NA 50% Human Human -DTXSID1045245 Css NA 2.42 mg/L PBTK NA 95% Human Human -DTXSID1045245 Clint NA 3.236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045245 Fup NA 0.2011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045245 Vd NA 1.288 L/kg 1compartment NA NA Rat Human +DTXSID1045245 TK.Half.Life NA 3.082 hours 1compartment NA NA Human Human +DTXSID1045245 Css NA 0.2126 mg/L 3compartmentss NA 50% Human Human +DTXSID1045245 Css NA 1.707 mg/L 3compartmentss NA 95% Human Human +DTXSID1045245 Css NA 0.1442 mg/L PBTK NA 50% Human Human +DTXSID1045245 Css NA 1.094 mg/L PBTK NA 95% Human Human +DTXSID1045245 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045245 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045245 Vd NA 1.061 L/kg 1compartment NA NA Rat Human DTXSID1045245 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045245 TK.Half.Life NA 4.178 hours 1compartment NA NA Rat Human -DTXSID1045245 Css NA 0.3766 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045245 Css NA 1.327 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045245 Css NA 0.2612 mg/L PBTK NA 50% Rat Human -DTXSID1045245 Css NA 0.8262 mg/L PBTK NA 95% Rat Human -DTXSID1045291 Clint NA 0.8038 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045291 Fup NA 0.0232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045291 Vd NA 0.7254 L/kg 1compartment NA NA Human Human -DTXSID1045291 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID1045291 TK.Half.Life NA 85.57 hours 1compartment NA NA Human Human -DTXSID1045291 Css NA 20.26 mg/L 3compartmentss NA 50% Human Human -DTXSID1045291 Css NA 128.7 mg/L 3compartmentss NA 95% Human Human -DTXSID1045291 Css NA 12.2 mg/L PBTK NA 50% Human Human -DTXSID1045291 Css NA 75.83 mg/L PBTK NA 95% Human Human -DTXSID1045291 Clint NA 0.8038 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045291 Fup NA 0.0232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045291 Vd NA 0.551 L/kg 1compartment NA NA Rat Human -DTXSID1045291 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID1045291 TK.Half.Life NA 30.31 hours 1compartment NA NA Rat Human -DTXSID1045291 Css NA 8.28 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045291 Css NA 46.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045291 Css NA 4.668 mg/L PBTK NA 50% Rat Human -DTXSID1045291 Css NA 25.36 mg/L PBTK NA 95% Rat Human -DTXSID1045293 Clint NA 52.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045293 Fup NA 0.0929 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045293 Vd NA 2.761 L/kg 1compartment NA NA Human Human +DTXSID1045245 TK.Half.Life NA 1.24 hours 1compartment NA NA Rat Human +DTXSID1045245 Css NA 0.02753 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045245 Css NA 0.162 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045245 Css NA 0.01821 mg/L PBTK NA 50% Rat Human +DTXSID1045245 Css NA 0.1011 mg/L PBTK NA 95% Rat Human +DTXSID1045291 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045291 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045291 Vd NA 0.8167 L/kg 1compartment NA NA Human Human +DTXSID1045291 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045291 TK.Half.Life NA 5.316 hours 1compartment NA NA Human Human +DTXSID1045291 Css NA 1.022 mg/L 3compartmentss NA 50% Human Human +DTXSID1045291 Css NA 9.682 mg/L 3compartmentss NA 95% Human Human +DTXSID1045291 Css NA 0.6193 mg/L PBTK NA 50% Human Human +DTXSID1045291 Css NA 5.7 mg/L PBTK NA 95% Human Human +DTXSID1045291 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045291 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045291 Vd NA 0.62 L/kg 1compartment NA NA Rat Human +DTXSID1045291 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1045291 TK.Half.Life NA 2.437 hours 1compartment NA NA Rat Human +DTXSID1045291 Css NA 0.1324 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045291 Css NA 0.9932 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045291 Css NA 0.078 mg/L PBTK NA 50% Rat Human +DTXSID1045291 Css NA 0.5739 mg/L PBTK NA 95% Rat Human +DTXSID1045293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045293 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045293 Vd NA 2.592 L/kg 1compartment NA NA Human Human DTXSID1045293 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045293 TK.Half.Life NA 4.206 hours 1compartment NA NA Human Human -DTXSID1045293 Css NA 0.1089 mg/L 3compartmentss NA 50% Human Human -DTXSID1045293 Css NA 0.8736 mg/L 3compartmentss NA 95% Human Human -DTXSID1045293 Css NA 0.08442 mg/L PBTK NA 50% Human Human -DTXSID1045293 Css NA 0.6213 mg/L PBTK NA 95% Human Human -DTXSID1045293 Clint NA 52.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045293 Fup NA 0.0929 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045293 Vd NA 2.363 L/kg 1compartment NA NA Rat Human +DTXSID1045293 TK.Half.Life NA 2.703 hours 1compartment NA NA Human Human +DTXSID1045293 Css NA 0.0448 mg/L 3compartmentss NA 50% Human Human +DTXSID1045293 Css NA 0.3775 mg/L 3compartmentss NA 95% Human Human +DTXSID1045293 Css NA 0.04405 mg/L PBTK NA 50% Human Human +DTXSID1045293 Css NA 0.3093 mg/L PBTK NA 95% Human Human +DTXSID1045293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045293 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045293 Vd NA 2.569 L/kg 1compartment NA NA Rat Human DTXSID1045293 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045293 TK.Half.Life NA 1.609 hours 1compartment NA NA Rat Human -DTXSID1045293 Css NA 0.06102 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045293 Css NA 0.379 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045293 Css NA 0.04533 mg/L PBTK NA 50% Rat Human -DTXSID1045293 Css NA 0.2588 mg/L PBTK NA 95% Rat Human -DTXSID1045297 Clint NA 120.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045297 Fup NA 0.06 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045297 Vd NA 3.149 L/kg 1compartment NA NA Human Human -DTXSID1045297 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045297 TK.Half.Life NA 9.061 hours 1compartment NA NA Human Human -DTXSID1045297 Css NA 0.2563 mg/L 3compartmentss NA 50% Human Human -DTXSID1045297 Css NA 1.625 mg/L 3compartmentss NA 95% Human Human -DTXSID1045297 Css NA 0.1792 mg/L PBTK NA 50% Human Human -DTXSID1045297 Css NA 1.098 mg/L PBTK NA 95% Human Human -DTXSID1045297 Clint NA 120.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045297 Fup NA 0.06 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045297 Vd NA 2.37 L/kg 1compartment NA NA Rat Human -DTXSID1045297 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045297 TK.Half.Life NA 1.691 hours 1compartment NA NA Rat Human -DTXSID1045297 Css NA 0.1441 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045297 Css NA 0.7854 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045297 Css NA 0.0964 mg/L PBTK NA 50% Rat Human -DTXSID1045297 Css NA 0.5044 mg/L PBTK NA 95% Rat Human -DTXSID1045320 Clint NA 29.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045320 Fup NA 0.2759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045320 Vd NA 3.048 L/kg 1compartment NA NA Human Human +DTXSID1045293 TK.Half.Life NA 1.429 hours 1compartment NA NA Rat Human +DTXSID1045293 Css NA 0.005413 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045293 Css NA 0.03641 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045293 Css NA 0.005491 mg/L PBTK NA 50% Rat Human +DTXSID1045293 Css NA 0.03009 mg/L PBTK NA 95% Rat Human +DTXSID1045320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045320 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045320 Vd NA 2.806 L/kg 1compartment NA NA Human Human DTXSID1045320 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045320 TK.Half.Life NA 10.59 hours 1compartment NA NA Human Human -DTXSID1045320 Css NA 0.3251 mg/L 3compartmentss NA 50% Human Human -DTXSID1045320 Css NA 2.085 mg/L 3compartmentss NA 95% Human Human -DTXSID1045320 Css NA 0.2374 mg/L PBTK NA 50% Human Human -DTXSID1045320 Css NA 1.47 mg/L PBTK NA 95% Human Human -DTXSID1045320 Clint NA 29.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045320 Fup NA 0.2759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045320 Vd NA 2.328 L/kg 1compartment NA NA Rat Human +DTXSID1045320 TK.Half.Life NA 5.344 hours 1compartment NA NA Human Human +DTXSID1045320 Css NA 0.1334 mg/L 3compartmentss NA 50% Human Human +DTXSID1045320 Css NA 0.8676 mg/L 3compartmentss NA 95% Human Human +DTXSID1045320 Css NA 0.1056 mg/L PBTK NA 50% Human Human +DTXSID1045320 Css NA 0.6529 mg/L PBTK NA 95% Human Human +DTXSID1045320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045320 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045320 Vd NA 2.216 L/kg 1compartment NA NA Rat Human DTXSID1045320 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045320 TK.Half.Life NA 2.148 hours 1compartment NA NA Rat Human -DTXSID1045320 Css NA 0.1788 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045320 Css NA 0.8737 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045320 Css NA 0.1258 mg/L PBTK NA 50% Rat Human -DTXSID1045320 Css NA 0.5959 mg/L PBTK NA 95% Rat Human -DTXSID1045322 Clint NA 31.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045322 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045322 Vd NA 2.73 L/kg 1compartment NA NA Human Human -DTXSID1045322 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045322 TK.Half.Life NA 1.376 hours 1compartment NA NA Human Human -DTXSID1045322 Css NA 0.01247 mg/L 3compartmentss NA 50% Human Human -DTXSID1045322 Css NA 0.177 mg/L 3compartmentss NA 95% Human Human -DTXSID1045322 Css NA 0.01387 mg/L PBTK NA 50% Human Human -DTXSID1045322 Css NA 0.1613 mg/L PBTK NA 95% Human Human -DTXSID1045322 Clint NA 31.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045322 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045322 Vd NA 2.78 L/kg 1compartment NA NA Rat Human -DTXSID1045322 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045322 TK.Half.Life NA 0.6736 hours 1compartment NA NA Rat Human -DTXSID1045322 Css NA 0.006175 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045322 Css NA 0.07323 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045322 Css NA 0.006988 mg/L PBTK NA 50% Rat Human -DTXSID1045322 Css NA 0.06288 mg/L PBTK NA 95% Rat Human -DTXSID1045324 Clint NA 112.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045324 Fup NA 0.0425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045324 Vd NA 2.292 L/kg 1compartment NA NA Human Human -DTXSID1045324 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045324 TK.Half.Life NA 4.652 hours 1compartment NA NA Human Human -DTXSID1045324 Css NA 0.1855 mg/L 3compartmentss NA 50% Human Human -DTXSID1045324 Css NA 1.442 mg/L 3compartmentss NA 95% Human Human -DTXSID1045324 Css NA 0.1226 mg/L PBTK NA 50% Human Human -DTXSID1045324 Css NA 0.9355 mg/L PBTK NA 95% Human Human -DTXSID1045324 Clint NA 112.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045324 Fup NA 0.0425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045324 Vd NA 1.716 L/kg 1compartment NA NA Rat Human +DTXSID1045320 TK.Half.Life NA 1.503 hours 1compartment NA NA Rat Human +DTXSID1045320 Css NA 0.01658 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045320 Css NA 0.08332 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045320 Css NA 0.01309 mg/L PBTK NA 50% Rat Human +DTXSID1045320 Css NA 0.06174 mg/L PBTK NA 95% Rat Human +DTXSID1045322 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045322 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045322 Vd NA 2.815 L/kg 1compartment NA NA Human Human +DTXSID1045322 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1045322 TK.Half.Life NA 31.05 hours 1compartment NA NA Human Human +DTXSID1045322 Css NA 0.8699 mg/L 3compartmentss NA 50% Human Human +DTXSID1045322 Css NA 7.48 mg/L 3compartmentss NA 95% Human Human +DTXSID1045322 Css NA 0.979 mg/L PBTK NA 50% Human Human +DTXSID1045322 Css NA 5.15 mg/L PBTK NA 95% Human Human +DTXSID1045322 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045322 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045322 Vd NA 2.859 L/kg 1compartment NA NA Rat Human +DTXSID1045322 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1045322 TK.Half.Life NA 10.73 hours 1compartment NA NA Rat Human +DTXSID1045322 Css NA 0.05124 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045322 Css NA 0.4153 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045322 Css NA 0.0593 mg/L PBTK NA 50% Rat Human +DTXSID1045322 Css NA 0.2842 mg/L PBTK NA 95% Rat Human +DTXSID1045324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045324 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045324 Vd NA 2.817 L/kg 1compartment NA NA Human Human +DTXSID1045324 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1045324 TK.Half.Life NA 14.52 hours 1compartment NA NA Human Human +DTXSID1045324 Css NA 0.5503 mg/L 3compartmentss NA 50% Human Human +DTXSID1045324 Css NA 3.708 mg/L 3compartmentss NA 95% Human Human +DTXSID1045324 Css NA 0.3872 mg/L PBTK NA 50% Human Human +DTXSID1045324 Css NA 2.485 mg/L PBTK NA 95% Human Human +DTXSID1045324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045324 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045324 Vd NA 2.127 L/kg 1compartment NA NA Rat Human DTXSID1045324 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045324 TK.Half.Life NA 1.402 hours 1compartment NA NA Rat Human -DTXSID1045324 Css NA 0.106 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045324 Css NA 0.6716 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045324 Css NA 0.06644 mg/L PBTK NA 50% Rat Human -DTXSID1045324 Css NA 0.3965 mg/L PBTK NA 95% Rat Human -DTXSID1045326 Clint NA 61.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045326 Fup NA 0.2325 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045326 Vd NA 43.08 L/kg 1compartment NA NA Human Human -DTXSID1045326 Days.Css NA 96 Days PBTK NA NA Human Human -DTXSID1045326 TK.Half.Life NA 443.5 hours 1compartment NA NA Human Human -DTXSID1045326 Css NA 0.1815 mg/L 3compartmentss NA 50% Human Human -DTXSID1045326 Css NA 1.123 mg/L 3compartmentss NA 95% Human Human -DTXSID1045326 Css NA 0.8468 mg/L PBTK NA 50% Human Human -DTXSID1045326 Css NA 4.642 mg/L PBTK NA 95% Human Human -DTXSID1045326 Clint NA 61.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045326 Fup NA 0.2325 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045326 Vd NA 36.11 L/kg 1compartment NA NA Rat Human -DTXSID1045326 Days.Css NA 62 Days PBTK NA NA Rat Human -DTXSID1045326 TK.Half.Life NA 63.42 hours 1compartment NA NA Rat Human -DTXSID1045326 Css NA 0.0924 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045326 Css NA 0.4252 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045326 Css NA 0.4606 mg/L PBTK NA 50% Rat Human -DTXSID1045326 Css NA 2.028 mg/L PBTK NA 95% Rat Human -DTXSID1045328 Clint NA 48.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045328 Fup NA 0.1293 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045328 Vd NA 2.794 L/kg 1compartment NA NA Human Human +DTXSID1045324 TK.Half.Life NA 3.1 hours 1compartment NA NA Rat Human +DTXSID1045324 Css NA 0.07112 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045324 Css NA 0.3623 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045324 Css NA 0.04962 mg/L PBTK NA 50% Rat Human +DTXSID1045324 Css NA 0.2513 mg/L PBTK NA 95% Rat Human +DTXSID1045328 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045328 Fup 0.412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045328 Vd NA 3.566 L/kg 1compartment NA NA Human Human DTXSID1045328 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045328 TK.Half.Life NA 2.756 hours 1compartment NA NA Human Human -DTXSID1045328 Css NA 0.0481 mg/L 3compartmentss NA 50% Human Human -DTXSID1045328 Css NA 0.4802 mg/L 3compartmentss NA 95% Human Human -DTXSID1045328 Css NA 0.04455 mg/L PBTK NA 50% Human Human -DTXSID1045328 Css NA 0.3645 mg/L PBTK NA 95% Human Human -DTXSID1045328 Clint NA 48.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045328 Fup NA 0.1293 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045328 Vd NA 2.781 L/kg 1compartment NA NA Rat Human +DTXSID1045328 TK.Half.Life NA 5.849 hours 1compartment NA NA Human Human +DTXSID1045328 Css NA 0.08978 mg/L 3compartmentss NA 50% Human Human +DTXSID1045328 Css NA 0.7476 mg/L 3compartmentss NA 95% Human Human +DTXSID1045328 Css NA 0.1107 mg/L PBTK NA 50% Human Human +DTXSID1045328 Css NA 0.6729 mg/L PBTK NA 95% Human Human +DTXSID1045328 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045328 Fup 0.412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045328 Vd NA 3.624 L/kg 1compartment NA NA Rat Human DTXSID1045328 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045328 TK.Half.Life NA 1.465 hours 1compartment NA NA Rat Human -DTXSID1045328 Css NA 0.02681 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045328 Css NA 0.208 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045328 Css NA 0.02414 mg/L PBTK NA 50% Rat Human -DTXSID1045328 Css NA 0.1509 mg/L PBTK NA 95% Rat Human -DTXSID1045370 Clint NA 20.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045370 Fup NA 0.4143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045370 Vd NA 0.8417 L/kg 1compartment NA NA Human Human +DTXSID1045328 TK.Half.Life NA 3.455 hours 1compartment NA NA Rat Human +DTXSID1045328 Css NA 0.01002 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045328 Css NA 0.0659 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045328 Css NA 0.01288 mg/L PBTK NA 50% Rat Human +DTXSID1045328 Css NA 0.05848 mg/L PBTK NA 95% Rat Human +DTXSID1045370 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045370 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045370 Vd NA 0.8404 L/kg 1compartment NA NA Human Human DTXSID1045370 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045370 TK.Half.Life NA 0.932 hours 1compartment NA NA Human Human -DTXSID1045370 Css NA 0.05202 mg/L 3compartmentss NA 50% Human Human -DTXSID1045370 Css NA 0.4103 mg/L 3compartmentss NA 95% Human Human -DTXSID1045370 Css NA 0.04 mg/L PBTK NA 50% Human Human -DTXSID1045370 Css NA 0.2819 mg/L PBTK NA 95% Human Human -DTXSID1045370 Clint NA 20.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045370 Fup NA 0.4143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045370 Vd NA 0.826 L/kg 1compartment NA NA Rat Human +DTXSID1045370 TK.Half.Life NA 8.042 hours 1compartment NA NA Human Human +DTXSID1045370 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human +DTXSID1045370 Css NA 7.063 mg/L 3compartmentss NA 95% Human Human +DTXSID1045370 Css NA 0.8713 mg/L PBTK NA 50% Human Human +DTXSID1045370 Css NA 4.46 mg/L PBTK NA 95% Human Human +DTXSID1045370 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045370 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045370 Vd NA 0.858 L/kg 1compartment NA NA Rat Human DTXSID1045370 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045370 TK.Half.Life NA 0.4731 hours 1compartment NA NA Rat Human -DTXSID1045370 Css NA 0.02756 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045370 Css NA 0.1661 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045370 Css NA 0.02049 mg/L PBTK NA 50% Rat Human -DTXSID1045370 Css NA 0.1092 mg/L PBTK NA 95% Rat Human -DTXSID1045372 Clint NA 60.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045372 Fup NA 0.0466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045372 Vd NA 2.221 L/kg 1compartment NA NA Human Human +DTXSID1045370 TK.Half.Life NA 2.796 hours 1compartment NA NA Rat Human +DTXSID1045370 Css NA 0.06371 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045370 Css NA 0.4114 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045370 Css NA 0.05254 mg/L PBTK NA 50% Rat Human +DTXSID1045370 Css NA 0.2528 mg/L PBTK NA 95% Rat Human +DTXSID1045372 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045372 Fup 0.0552 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045372 Vd NA 2.409 L/kg 1compartment NA NA Human Human DTXSID1045372 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045372 TK.Half.Life NA 3.952 hours 1compartment NA NA Human Human -DTXSID1045372 Css NA 0.153 mg/L 3compartmentss NA 50% Human Human -DTXSID1045372 Css NA 1.268 mg/L 3compartmentss NA 95% Human Human -DTXSID1045372 Css NA 0.1102 mg/L PBTK NA 50% Human Human -DTXSID1045372 Css NA 0.8434 mg/L PBTK NA 95% Human Human -DTXSID1045372 Clint NA 60.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045372 Fup NA 0.0466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045372 Vd NA 1.901 L/kg 1compartment NA NA Rat Human +DTXSID1045372 TK.Half.Life NA 7.799 hours 1compartment NA NA Human Human +DTXSID1045372 Css NA 0.353 mg/L 3compartmentss NA 50% Human Human +DTXSID1045372 Css NA 2.823 mg/L 3compartmentss NA 95% Human Human +DTXSID1045372 Css NA 0.2596 mg/L PBTK NA 50% Human Human +DTXSID1045372 Css NA 1.875 mg/L PBTK NA 95% Human Human +DTXSID1045372 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045372 Fup 0.0552 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045372 Vd NA 2.065 L/kg 1compartment NA NA Rat Human DTXSID1045372 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045372 TK.Half.Life NA 1.665 hours 1compartment NA NA Rat Human -DTXSID1045372 Css NA 0.08675 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045372 Css NA 0.5592 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045372 Css NA 0.05914 mg/L PBTK NA 50% Rat Human -DTXSID1045372 Css NA 0.3564 mg/L PBTK NA 95% Rat Human -DTXSID1045376 Clint NA 0.7121 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045376 Fup NA 0.884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045376 Vd NA 1.308 L/kg 1compartment NA NA Human Human +DTXSID1045372 TK.Half.Life NA 3.277 hours 1compartment NA NA Rat Human +DTXSID1045372 Css NA 0.04581 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045372 Css NA 0.2891 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045372 Css NA 0.03332 mg/L PBTK NA 50% Rat Human +DTXSID1045372 Css NA 0.1908 mg/L PBTK NA 95% Rat Human +DTXSID1045376 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045376 Fup 0.758 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045376 Vd NA 0.4535 L/kg 1compartment NA NA Human Human DTXSID1045376 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045376 TK.Half.Life NA 4.612 hours 1compartment NA NA Human Human -DTXSID1045376 Css NA 0.3952 mg/L 3compartmentss NA 50% Human Human -DTXSID1045376 Css NA 2.464 mg/L 3compartmentss NA 95% Human Human -DTXSID1045376 Css NA 0.3549 mg/L PBTK NA 50% Human Human -DTXSID1045376 Css NA 1.67 mg/L PBTK NA 95% Human Human -DTXSID1045376 Clint NA 0.7121 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045376 Fup NA 0.884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045376 Vd NA 1.333 L/kg 1compartment NA NA Rat Human +DTXSID1045376 TK.Half.Life NA 3.87 hours 1compartment NA NA Human Human +DTXSID1045376 Css NA 0.9785 mg/L 3compartmentss NA 50% Human Human +DTXSID1045376 Css NA 5.797 mg/L 3compartmentss NA 95% Human Human +DTXSID1045376 Css NA 0.7229 mg/L PBTK NA 50% Human Human +DTXSID1045376 Css NA 3.595 mg/L PBTK NA 95% Human Human +DTXSID1045376 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045376 Fup 0.758 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045376 Vd NA 0.4718 L/kg 1compartment NA NA Rat Human DTXSID1045376 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045376 TK.Half.Life NA 2.158 hours 1compartment NA NA Rat Human -DTXSID1045376 Css NA 0.1392 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045376 Css NA 0.8387 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045376 Css NA 0.1239 mg/L PBTK NA 50% Rat Human -DTXSID1045376 Css NA 0.5246 mg/L PBTK NA 95% Rat Human -DTXSID1045405 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045405 Fup NA 0.4044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045405 Vd NA 1.227 L/kg 1compartment NA NA Human Human -DTXSID1045405 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1045405 TK.Half.Life NA 19.65 hours 1compartment NA NA Human Human -DTXSID1045405 Css NA 1.618 mg/L 3compartmentss NA 50% Human Human -DTXSID1045405 Css NA 7.35 mg/L 3compartmentss NA 95% Human Human -DTXSID1045405 Css NA 1.334 mg/L PBTK NA 50% Human Human -DTXSID1045405 Css NA 4.909 mg/L PBTK NA 95% Human Human -DTXSID1045405 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045405 Fup NA 0.4044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045405 Vd NA 1.236 L/kg 1compartment NA NA Rat Human +DTXSID1045376 TK.Half.Life NA 1.372 hours 1compartment NA NA Rat Human +DTXSID1045376 Css NA 0.02621 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045376 Css NA 0.1743 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045376 Css NA 0.01859 mg/L PBTK NA 50% Rat Human +DTXSID1045376 Css NA 0.1058 mg/L PBTK NA 95% Rat Human +DTXSID1045405 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045405 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045405 Vd NA 0.3591 L/kg 1compartment NA NA Human Human +DTXSID1045405 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045405 TK.Half.Life NA 9.222 hours 1compartment NA NA Human Human +DTXSID1045405 Css NA 1.692 mg/L 3compartmentss NA 50% Human Human +DTXSID1045405 Css NA 6.951 mg/L 3compartmentss NA 95% Human Human +DTXSID1045405 Css NA 1.122 mg/L PBTK NA 50% Human Human +DTXSID1045405 Css NA 4.247 mg/L PBTK NA 95% Human Human +DTXSID1045405 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045405 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045405 Vd NA 0.3672 L/kg 1compartment NA NA Rat Human DTXSID1045405 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045405 TK.Half.Life NA 6.743 hours 1compartment NA NA Rat Human -DTXSID1045405 Css NA 0.4372 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045405 Css NA 1.753 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045405 Css NA 0.3488 mg/L PBTK NA 50% Rat Human -DTXSID1045405 Css NA 1.091 mg/L PBTK NA 95% Rat Human -DTXSID1045453 Clint NA 127.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045453 Fup NA 0.1625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045453 Vd NA 2.81 L/kg 1compartment NA NA Human Human +DTXSID1045405 TK.Half.Life NA 3.213 hours 1compartment NA NA Rat Human +DTXSID1045405 Css NA 0.009208 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045405 Css NA 0.03797 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045405 Css NA 0.005766 mg/L PBTK NA 50% Rat Human +DTXSID1045405 Css NA 0.02212 mg/L PBTK NA 95% Rat Human +DTXSID1045409 Clint 128 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID1045409 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1045409 Vd NA 0.43 L/kg 1compartment NA NA Human Human +DTXSID1045409 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045409 TK.Half.Life NA 3.794 hours 1compartment NA NA Human Human +DTXSID1045409 Css NA 1.496 mg/L 3compartmentss NA 50% Human Human +DTXSID1045409 Css NA 13.76 mg/L 3compartmentss NA 95% Human Human +DTXSID1045409 Css NA 0.882 mg/L PBTK NA 50% Human Human +DTXSID1045409 Css NA 7.963 mg/L PBTK NA 95% Human Human +DTXSID1045409 Clint 128 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID1045409 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1045409 Vd NA 0.3313 L/kg 1compartment NA NA Rat Human +DTXSID1045409 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1045409 TK.Half.Life NA 1.92 hours 1compartment NA NA Rat Human +DTXSID1045409 Css NA 0.2024 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045409 Css NA 1.411 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045409 Css NA 0.1148 mg/L PBTK NA 50% Rat Human +DTXSID1045409 Css NA 0.7978 mg/L PBTK NA 95% Rat Human +DTXSID1045453 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045453 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045453 Vd NA 1.803 L/kg 1compartment NA NA Human Human DTXSID1045453 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045453 TK.Half.Life NA 3.529 hours 1compartment NA NA Human Human -DTXSID1045453 Css NA 0.06163 mg/L 3compartmentss NA 50% Human Human -DTXSID1045453 Css NA 0.4022 mg/L 3compartmentss NA 95% Human Human -DTXSID1045453 Css NA 0.045 mg/L PBTK NA 50% Human Human -DTXSID1045453 Css NA 0.278 mg/L PBTK NA 95% Human Human -DTXSID1045453 Clint NA 127.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045453 Fup NA 0.1625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045453 Vd NA 2.178 L/kg 1compartment NA NA Rat Human +DTXSID1045453 TK.Half.Life NA 3.536 hours 1compartment NA NA Human Human +DTXSID1045453 Css NA 0.1429 mg/L 3compartmentss NA 50% Human Human +DTXSID1045453 Css NA 0.9756 mg/L 3compartmentss NA 95% Human Human +DTXSID1045453 Css NA 0.1025 mg/L PBTK NA 50% Human Human +DTXSID1045453 Css NA 0.6552 mg/L PBTK NA 95% Human Human +DTXSID1045453 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045453 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045453 Vd NA 1.385 L/kg 1compartment NA NA Rat Human DTXSID1045453 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045453 TK.Half.Life NA 1.045 hours 1compartment NA NA Rat Human -DTXSID1045453 Css NA 0.03424 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045453 Css NA 0.1874 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045453 Css NA 0.024 mg/L PBTK NA 50% Rat Human -DTXSID1045453 Css NA 0.1247 mg/L PBTK NA 95% Rat Human -DTXSID1045459 Clint NA 75.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045459 Fup NA 0.2269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045459 Vd NA 0.6733 L/kg 1compartment NA NA Human Human +DTXSID1045453 TK.Half.Life NA 1.251 hours 1compartment NA NA Rat Human +DTXSID1045453 Css NA 0.01838 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045453 Css NA 0.0927 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045453 Css NA 0.01307 mg/L PBTK NA 50% Rat Human +DTXSID1045453 Css NA 0.06208 mg/L PBTK NA 95% Rat Human +DTXSID1045459 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045459 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045459 Vd NA 0.9247 L/kg 1compartment NA NA Human Human DTXSID1045459 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045459 TK.Half.Life NA 0.6782 hours 1compartment NA NA Human Human -DTXSID1045459 Css NA 0.02861 mg/L 3compartmentss NA 50% Human Human -DTXSID1045459 Css NA 0.2203 mg/L 3compartmentss NA 95% Human Human -DTXSID1045459 Css NA 0.01986 mg/L PBTK NA 50% Human Human -DTXSID1045459 Css NA 0.1432 mg/L PBTK NA 95% Human Human -DTXSID1045459 Clint NA 75.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045459 Fup NA 0.2269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045459 Vd NA 0.6574 L/kg 1compartment NA NA Rat Human +DTXSID1045459 TK.Half.Life NA 1.193 hours 1compartment NA NA Human Human +DTXSID1045459 Css NA 0.05468 mg/L 3compartmentss NA 50% Human Human +DTXSID1045459 Css NA 0.4624 mg/L 3compartmentss NA 95% Human Human +DTXSID1045459 Css NA 0.04078 mg/L PBTK NA 50% Human Human +DTXSID1045459 Css NA 0.3136 mg/L PBTK NA 95% Human Human +DTXSID1045459 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045459 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045459 Vd NA 0.8865 L/kg 1compartment NA NA Rat Human DTXSID1045459 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045459 TK.Half.Life NA 0.3231 hours 1compartment NA NA Rat Human -DTXSID1045459 Css NA 0.0161 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045459 Css NA 0.09368 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045459 Css NA 0.01063 mg/L PBTK NA 50% Rat Human -DTXSID1045459 Css NA 0.05726 mg/L PBTK NA 95% Rat Human -DTXSID1045530 Clint NA 5.036 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045530 Fup NA 0.6294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045530 Vd NA 0.6796 L/kg 1compartment NA NA Human Human +DTXSID1045459 TK.Half.Life NA 0.6086 hours 1compartment NA NA Rat Human +DTXSID1045459 Css NA 0.002606 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045459 Css NA 0.02368 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045459 Css NA 0.001929 mg/L PBTK NA 50% Rat Human +DTXSID1045459 Css NA 0.01546 mg/L PBTK NA 95% Rat Human +DTXSID1045530 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045530 Fup 0.536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045530 Vd NA 0.3927 L/kg 1compartment NA NA Human Human DTXSID1045530 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045530 TK.Half.Life NA 1.107 hours 1compartment NA NA Human Human -DTXSID1045530 Css NA 0.1399 mg/L 3compartmentss NA 50% Human Human -DTXSID1045530 Css NA 1.126 mg/L 3compartmentss NA 95% Human Human -DTXSID1045530 Css NA 0.1096 mg/L PBTK NA 50% Human Human -DTXSID1045530 Css NA 0.7523 mg/L PBTK NA 95% Human Human -DTXSID1045530 Clint NA 5.036 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045530 Fup NA 0.6294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045530 Vd NA 0.6868 L/kg 1compartment NA NA Rat Human +DTXSID1045530 TK.Half.Life NA 4.741 hours 1compartment NA NA Human Human +DTXSID1045530 Css NA 1.279 mg/L 3compartmentss NA 50% Human Human +DTXSID1045530 Css NA 7.436 mg/L 3compartmentss NA 95% Human Human +DTXSID1045530 Css NA 0.9088 mg/L PBTK NA 50% Human Human +DTXSID1045530 Css NA 4.507 mg/L PBTK NA 95% Human Human +DTXSID1045530 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045530 Fup 0.536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045530 Vd NA 0.4062 L/kg 1compartment NA NA Rat Human DTXSID1045530 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045530 TK.Half.Life NA 0.6033 hours 1compartment NA NA Rat Human -DTXSID1045530 Css NA 0.06564 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045530 Css NA 0.486 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045530 Css NA 0.04981 mg/L PBTK NA 50% Rat Human -DTXSID1045530 Css NA 0.2889 mg/L PBTK NA 95% Rat Human -DTXSID1045534 Clint NA 25.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1045530 TK.Half.Life NA 1.671 hours 1compartment NA NA Rat Human +DTXSID1045530 Css NA 0.03312 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045530 Css NA 0.2288 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045530 Css NA 0.0229 mg/L PBTK NA 50% Rat Human +DTXSID1045530 Css NA 0.1377 mg/L PBTK NA 95% Rat Human +DTXSID1045534 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1045534 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1045534 Vd NA 0.6944 L/kg 1compartment NA NA Human Human +DTXSID1045534 Vd NA 0.3425 L/kg 1compartment NA NA Human Human DTXSID1045534 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045534 TK.Half.Life NA 0.962 hours 1compartment NA NA Human Human -DTXSID1045534 Css NA 0.07853 mg/L 3compartmentss NA 50% Human Human -DTXSID1045534 Css NA 0.5706 mg/L 3compartmentss NA 95% Human Human -DTXSID1045534 Css NA 0.05572 mg/L PBTK NA 50% Human Human -DTXSID1045534 Css NA 0.3721 mg/L PBTK NA 95% Human Human -DTXSID1045534 Clint NA 25.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1045534 TK.Half.Life NA 9.244 hours 1compartment NA NA Human Human +DTXSID1045534 Css NA 3.245 mg/L 3compartmentss NA 50% Human Human +DTXSID1045534 Css NA 12.04 mg/L 3compartmentss NA 95% Human Human +DTXSID1045534 Css NA 2.121 mg/L PBTK NA 50% Human Human +DTXSID1045534 Css NA 7.258 mg/L PBTK NA 95% Human Human +DTXSID1045534 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1045534 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1045534 Vd NA 0.6044 L/kg 1compartment NA NA Rat Human +DTXSID1045534 Vd NA 0.3393 L/kg 1compartment NA NA Rat Human DTXSID1045534 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045534 TK.Half.Life NA 0.4438 hours 1compartment NA NA Rat Human -DTXSID1045534 Css NA 0.04366 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045534 Css NA 0.2349 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045534 Css NA 0.02954 mg/L PBTK NA 50% Rat Human -DTXSID1045534 Css NA 0.1497 mg/L PBTK NA 95% Rat Human +DTXSID1045534 TK.Half.Life NA 3.118 hours 1compartment NA NA Rat Human +DTXSID1045534 Css NA 0.211 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045534 Css NA 0.6508 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045534 Css NA 0.1352 mg/L PBTK NA 50% Rat Human +DTXSID1045534 Css NA 0.3829 mg/L PBTK NA 95% Rat Human DTXSID1045536 Clint 0.456 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID1045536 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1045536 Vd NA 2.155 L/kg 1compartment NA NA Human Human DTXSID1045536 Days.Css NA 7 Days PBTK NA NA Human Human DTXSID1045536 TK.Half.Life NA 47.38 hours 1compartment NA NA Human Human -DTXSID1045536 Css NA 1.966 mg/L 3compartmentss NA 50% Human Human -DTXSID1045536 Css NA 11.5 mg/L 3compartmentss NA 95% Human Human -DTXSID1045536 Css NA 1.914 mg/L PBTK NA 50% Human Human -DTXSID1045536 Css NA 8.164 mg/L PBTK NA 95% Human Human +DTXSID1045536 Css NA 1.881 mg/L 3compartmentss NA 50% Human Human +DTXSID1045536 Css NA 7.836 mg/L 3compartmentss NA 95% Human Human +DTXSID1045536 Css NA 1.88 mg/L PBTK NA 50% Human Human +DTXSID1045536 Css NA 7.834 mg/L PBTK NA 95% Human Human DTXSID1045536 Clint 0.456 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID1045536 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1045536 Vd NA 2.879 L/kg 1compartment NA NA Rat Human DTXSID1045536 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID1045536 TK.Half.Life NA 18.72 hours 1compartment NA NA Rat Human -DTXSID1045536 Css NA 0.4298 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045536 Css NA 1.741 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045536 Css NA 0.417 mg/L PBTK NA 50% Rat Human -DTXSID1045536 Css NA 1.214 mg/L PBTK NA 95% Rat Human -DTXSID1045538 Clint NA 24.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045538 Fup NA 0.5657 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045538 Vd NA 0.5915 L/kg 1compartment NA NA Human Human +DTXSID1045536 Css NA 0.09299 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045536 Css NA 0.2725 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045536 Css NA 0.0963 mg/L PBTK NA 50% Rat Human +DTXSID1045536 Css NA 0.2822 mg/L PBTK NA 95% Rat Human +DTXSID1045538 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045538 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045538 Vd NA 0.4962 L/kg 1compartment NA NA Human Human DTXSID1045538 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045538 TK.Half.Life NA 0.5559 hours 1compartment NA NA Human Human -DTXSID1045538 Css NA 0.03618 mg/L 3compartmentss NA 50% Human Human -DTXSID1045538 Css NA 0.3637 mg/L 3compartmentss NA 95% Human Human -DTXSID1045538 Css NA 0.02702 mg/L PBTK NA 50% Human Human -DTXSID1045538 Css NA 0.2361 mg/L PBTK NA 95% Human Human -DTXSID1045538 Clint NA 24.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045538 Fup NA 0.5657 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045538 Vd NA 0.578 L/kg 1compartment NA NA Rat Human +DTXSID1045538 TK.Half.Life NA 1.183 hours 1compartment NA NA Human Human +DTXSID1045538 Css NA 0.1062 mg/L 3compartmentss NA 50% Human Human +DTXSID1045538 Css NA 0.7693 mg/L 3compartmentss NA 95% Human Human +DTXSID1045538 Css NA 0.07396 mg/L PBTK NA 50% Human Human +DTXSID1045538 Css NA 0.4986 mg/L PBTK NA 95% Human Human +DTXSID1045538 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045538 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045538 Vd NA 0.4728 L/kg 1compartment NA NA Rat Human DTXSID1045538 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045538 TK.Half.Life NA 0.2667 hours 1compartment NA NA Rat Human -DTXSID1045538 Css NA 0.01874 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045538 Css NA 0.1666 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045538 Css NA 0.01356 mg/L PBTK NA 50% Rat Human -DTXSID1045538 Css NA 0.1019 mg/L PBTK NA 95% Rat Human -DTXSID1045580 Clint NA 31.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045580 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045580 Vd NA 2.286 L/kg 1compartment NA NA Human Human -DTXSID1045580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045580 TK.Half.Life NA 1.223 hours 1compartment NA NA Human Human -DTXSID1045580 Css NA 0.01356 mg/L 3compartmentss NA 50% Human Human -DTXSID1045580 Css NA 0.1752 mg/L 3compartmentss NA 95% Human Human -DTXSID1045580 Css NA 0.01408 mg/L PBTK NA 50% Human Human -DTXSID1045580 Css NA 0.1568 mg/L PBTK NA 95% Human Human -DTXSID1045580 Clint NA 31.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045580 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045580 Vd NA 2.328 L/kg 1compartment NA NA Rat Human +DTXSID1045538 TK.Half.Life NA 0.6348 hours 1compartment NA NA Rat Human +DTXSID1045538 Css NA 0.0009958 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045538 Css NA 0.00636 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045538 Css NA 0.0006625 mg/L PBTK NA 50% Rat Human +DTXSID1045538 Css NA 0.003871 mg/L PBTK NA 95% Rat Human +DTXSID1045580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045580 Fup 0.712 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045580 Vd NA 1.53 L/kg 1compartment NA NA Human Human +DTXSID1045580 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1045580 TK.Half.Life NA 13.9 hours 1compartment NA NA Human Human +DTXSID1045580 Css NA 0.9064 mg/L 3compartmentss NA 50% Human Human +DTXSID1045580 Css NA 6.351 mg/L 3compartmentss NA 95% Human Human +DTXSID1045580 Css NA 0.8473 mg/L PBTK NA 50% Human Human +DTXSID1045580 Css NA 4.219 mg/L PBTK NA 95% Human Human +DTXSID1045580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045580 Fup 0.712 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045580 Vd NA 1.559 L/kg 1compartment NA NA Rat Human DTXSID1045580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045580 TK.Half.Life NA 0.595 hours 1compartment NA NA Rat Human -DTXSID1045580 Css NA 0.006744 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045580 Css NA 0.07367 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045580 Css NA 0.007134 mg/L PBTK NA 50% Rat Human -DTXSID1045580 Css NA 0.06319 mg/L PBTK NA 95% Rat Human -DTXSID1045582 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045582 Fup NA 0.0874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045582 Vd NA 0.6936 L/kg 1compartment NA NA Human Human -DTXSID1045582 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID1045582 TK.Half.Life NA 52.43 hours 1compartment NA NA Human Human -DTXSID1045582 Css NA 10.31 mg/L 3compartmentss NA 50% Human Human -DTXSID1045582 Css NA 50.83 mg/L 3compartmentss NA 95% Human Human -DTXSID1045582 Css NA 7.324 mg/L PBTK NA 50% Human Human -DTXSID1045582 Css NA 31.5 mg/L PBTK NA 95% Human Human -DTXSID1045582 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045582 Fup NA 0.0874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045582 Vd NA 0.6416 L/kg 1compartment NA NA Rat Human -DTXSID1045582 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1045582 TK.Half.Life NA 16.27 hours 1compartment NA NA Rat Human -DTXSID1045582 Css NA 2.931 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045582 Css NA 12.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045582 Css NA 1.964 mg/L PBTK NA 50% Rat Human -DTXSID1045582 Css NA 6.994 mg/L PBTK NA 95% Rat Human -DTXSID1045584 Clint NA 0.118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045584 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045584 Vd NA 0.2885 L/kg 1compartment NA NA Human Human -DTXSID1045584 Days.Css NA 65 Days PBTK NA NA Human Human -DTXSID1045584 TK.Half.Life NA 266.7 hours 1compartment NA NA Human Human -DTXSID1045584 Css NA 157 mg/L 3compartmentss NA 50% Human Human -DTXSID1045584 Css NA 957.4 mg/L 3compartmentss NA 95% Human Human -DTXSID1045584 Css NA 91.86 mg/L PBTK NA 50% Human Human -DTXSID1045584 Css NA 556.4 mg/L PBTK NA 95% Human Human -DTXSID1045584 Clint NA 0.118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045584 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045584 Vd NA 0.2375 L/kg 1compartment NA NA Rat Human -DTXSID1045584 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID1045584 TK.Half.Life NA 81.82 hours 1compartment NA NA Rat Human -DTXSID1045584 Css NA 50.54 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045584 Css NA 279.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045584 Css NA 27.53 mg/L PBTK NA 50% Rat Human -DTXSID1045584 Css NA 151.3 mg/L PBTK NA 95% Rat Human -DTXSID1045586 Clint NA 18.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045586 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045586 Vd NA 3.112 L/kg 1compartment NA NA Human Human -DTXSID1045586 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID1045586 TK.Half.Life NA 91.32 hours 1compartment NA NA Human Human -DTXSID1045586 Css NA 3.55 mg/L 3compartmentss NA 50% Human Human -DTXSID1045586 Css NA 22.77 mg/L 3compartmentss NA 95% Human Human -DTXSID1045586 Css NA 2.47 mg/L PBTK NA 50% Human Human -DTXSID1045586 Css NA 15.04 mg/L PBTK NA 95% Human Human -DTXSID1045586 Clint NA 18.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045586 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045586 Vd NA 2.332 L/kg 1compartment NA NA Rat Human -DTXSID1045586 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID1045586 TK.Half.Life NA 12.4 hours 1compartment NA NA Rat Human -DTXSID1045586 Css NA 2.014 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045586 Css NA 10.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045586 Css NA 1.337 mg/L PBTK NA 50% Rat Human -DTXSID1045586 Css NA 6.629 mg/L PBTK NA 95% Rat Human -DTXSID1045588 Clint NA 7.111 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045588 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045588 Vd NA 3.364 L/kg 1compartment NA NA Human Human -DTXSID1045588 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045588 TK.Half.Life NA 2.726 hours 1compartment NA NA Human Human -DTXSID1045588 Css NA 0.0471 mg/L 3compartmentss NA 50% Human Human -DTXSID1045588 Css NA 0.5444 mg/L 3compartmentss NA 95% Human Human -DTXSID1045588 Css NA 0.05744 mg/L PBTK NA 50% Human Human -DTXSID1045588 Css NA 0.4986 mg/L PBTK NA 95% Human Human -DTXSID1045588 Clint NA 7.111 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045588 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045588 Vd NA 3.423 L/kg 1compartment NA NA Rat Human +DTXSID1045580 TK.Half.Life NA 4.827 hours 1compartment NA NA Rat Human +DTXSID1045580 Css NA 0.05344 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045580 Css NA 0.3878 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045580 Css NA 0.0508 mg/L PBTK NA 50% Rat Human +DTXSID1045580 Css NA 0.2476 mg/L PBTK NA 95% Rat Human +DTXSID1045582 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045582 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045582 Vd NA 0.4118 L/kg 1compartment NA NA Human Human +DTXSID1045582 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1045582 TK.Half.Life NA 13.88 hours 1compartment NA NA Human Human +DTXSID1045582 Css NA 3.382 mg/L 3compartmentss NA 50% Human Human +DTXSID1045582 Css NA 12.92 mg/L 3compartmentss NA 95% Human Human +DTXSID1045582 Css NA 2.308 mg/L PBTK NA 50% Human Human +DTXSID1045582 Css NA 8.105 mg/L PBTK NA 95% Human Human +DTXSID1045582 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045582 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045582 Vd NA 0.4086 L/kg 1compartment NA NA Rat Human +DTXSID1045582 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1045582 TK.Half.Life NA 4.693 hours 1compartment NA NA Rat Human +DTXSID1045582 Css NA 0.08202 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045582 Css NA 0.443 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045582 Css NA 0.05506 mg/L PBTK NA 50% Rat Human +DTXSID1045582 Css NA 0.2705 mg/L PBTK NA 95% Rat Human +DTXSID1045584 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045584 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045584 Vd NA 0.2324 L/kg 1compartment NA NA Human Human +DTXSID1045584 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045584 TK.Half.Life NA 1.373 hours 1compartment NA NA Human Human +DTXSID1045584 Css NA 0.846 mg/L 3compartmentss NA 50% Human Human +DTXSID1045584 Css NA 6.011 mg/L 3compartmentss NA 95% Human Human +DTXSID1045584 Css NA 0.5129 mg/L PBTK NA 50% Human Human +DTXSID1045584 Css NA 3.498 mg/L PBTK NA 95% Human Human +DTXSID1045584 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045584 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045584 Vd NA 0.2334 L/kg 1compartment NA NA Rat Human +DTXSID1045584 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1045584 TK.Half.Life NA 0.8356 hours 1compartment NA NA Rat Human +DTXSID1045584 Css NA 0.1034 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045584 Css NA 0.5327 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045584 Css NA 0.06079 mg/L PBTK NA 50% Rat Human +DTXSID1045584 Css NA 0.3029 mg/L PBTK NA 95% Rat Human +DTXSID1045586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045586 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045586 Vd NA 0.8831 L/kg 1compartment NA NA Human Human +DTXSID1045586 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045586 TK.Half.Life NA 1.544 hours 1compartment NA NA Human Human +DTXSID1045586 Css NA 0.1207 mg/L 3compartmentss NA 50% Human Human +DTXSID1045586 Css NA 0.9625 mg/L 3compartmentss NA 95% Human Human +DTXSID1045586 Css NA 0.08473 mg/L PBTK NA 50% Human Human +DTXSID1045586 Css NA 0.6275 mg/L PBTK NA 95% Human Human +DTXSID1045586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045586 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045586 Vd NA 0.844 L/kg 1compartment NA NA Rat Human +DTXSID1045586 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1045586 TK.Half.Life NA 0.8288 hours 1compartment NA NA Rat Human +DTXSID1045586 Css NA 0.01552 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045586 Css NA 0.09015 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045586 Css NA 0.01076 mg/L PBTK NA 50% Rat Human +DTXSID1045586 Css NA 0.05818 mg/L PBTK NA 95% Rat Human +DTXSID1045588 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045588 Fup 0.824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045588 Vd NA 1.454 L/kg 1compartment NA NA Human Human +DTXSID1045588 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1045588 TK.Half.Life NA 11.42 hours 1compartment NA NA Human Human +DTXSID1045588 Css NA 0.826 mg/L 3compartmentss NA 50% Human Human +DTXSID1045588 Css NA 5.36 mg/L 3compartmentss NA 95% Human Human +DTXSID1045588 Css NA 0.7859 mg/L PBTK NA 50% Human Human +DTXSID1045588 Css NA 3.677 mg/L PBTK NA 95% Human Human +DTXSID1045588 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045588 Fup 0.824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045588 Vd NA 1.492 L/kg 1compartment NA NA Rat Human DTXSID1045588 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045588 TK.Half.Life NA 1.507 hours 1compartment NA NA Rat Human -DTXSID1045588 Css NA 0.02185 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045588 Css NA 0.2046 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045588 Css NA 0.02739 mg/L PBTK NA 50% Rat Human -DTXSID1045588 Css NA 0.1587 mg/L PBTK NA 95% Rat Human -DTXSID1045611 Clint NA 14.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045611 Fup NA 0.0561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045611 Vd NA 0.4738 L/kg 1compartment NA NA Human Human +DTXSID1045588 TK.Half.Life NA 3.993 hours 1compartment NA NA Rat Human +DTXSID1045588 Css NA 0.04824 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045588 Css NA 0.3114 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045588 Css NA 0.04648 mg/L PBTK NA 50% Rat Human +DTXSID1045588 Css NA 0.2027 mg/L PBTK NA 95% Rat Human +DTXSID1045611 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045611 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045611 Vd NA 1.081 L/kg 1compartment NA NA Human Human DTXSID1045611 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045611 TK.Half.Life NA 2.519 hours 1compartment NA NA Human Human -DTXSID1045611 Css NA 0.8035 mg/L 3compartmentss NA 50% Human Human -DTXSID1045611 Css NA 6.053 mg/L 3compartmentss NA 95% Human Human -DTXSID1045611 Css NA 0.4925 mg/L PBTK NA 50% Human Human -DTXSID1045611 Css NA 3.628 mg/L PBTK NA 95% Human Human -DTXSID1045611 Clint NA 14.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045611 Fup NA 0.0561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045611 Vd NA 0.4252 L/kg 1compartment NA NA Rat Human +DTXSID1045611 TK.Half.Life NA 3.142 hours 1compartment NA NA Human Human +DTXSID1045611 Css NA 0.2589 mg/L 3compartmentss NA 50% Human Human +DTXSID1045611 Css NA 1.563 mg/L 3compartmentss NA 95% Human Human +DTXSID1045611 Css NA 0.1927 mg/L PBTK NA 50% Human Human +DTXSID1045611 Css NA 1.058 mg/L PBTK NA 95% Human Human +DTXSID1045611 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045611 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045611 Vd NA 0.9847 L/kg 1compartment NA NA Rat Human DTXSID1045611 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045611 TK.Half.Life NA 1.414 hours 1compartment NA NA Rat Human -DTXSID1045611 Css NA 0.4525 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045611 Css NA 2.595 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045611 Css NA 0.26 mg/L PBTK NA 50% Rat Human -DTXSID1045611 Css NA 1.433 mg/L PBTK NA 95% Rat Human -DTXSID1045615 Clint NA 3.568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045615 Fup NA 0.6243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045615 Vd NA 3.956 L/kg 1compartment NA NA Human Human +DTXSID1045611 TK.Half.Life NA 1.613 hours 1compartment NA NA Rat Human +DTXSID1045611 Css NA 0.03042 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045611 Css NA 0.1364 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045611 Css NA 0.02261 mg/L PBTK NA 50% Rat Human +DTXSID1045611 Css NA 0.08957 mg/L PBTK NA 95% Rat Human +DTXSID1045615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045615 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045615 Vd NA 2.067 L/kg 1compartment NA NA Human Human DTXSID1045615 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045615 TK.Half.Life NA 6.359 hours 1compartment NA NA Human Human -DTXSID1045615 Css NA 0.09378 mg/L 3compartmentss NA 50% Human Human -DTXSID1045615 Css NA 1.046 mg/L 3compartmentss NA 95% Human Human -DTXSID1045615 Css NA 0.1354 mg/L PBTK NA 50% Human Human -DTXSID1045615 Css NA 0.9217 mg/L PBTK NA 95% Human Human -DTXSID1045615 Clint NA 3.568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045615 Fup NA 0.6243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045615 Vd NA 3.963 L/kg 1compartment NA NA Rat Human +DTXSID1045615 TK.Half.Life NA 5.554 hours 1compartment NA NA Human Human +DTXSID1045615 Css NA 0.1946 mg/L 3compartmentss NA 50% Human Human +DTXSID1045615 Css NA 1.338 mg/L 3compartmentss NA 95% Human Human +DTXSID1045615 Css NA 0.1863 mg/L PBTK NA 50% Human Human +DTXSID1045615 Css NA 1.082 mg/L PBTK NA 95% Human Human +DTXSID1045615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045615 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045615 Vd NA 2.044 L/kg 1compartment NA NA Rat Human DTXSID1045615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045615 TK.Half.Life NA 3.637 hours 1compartment NA NA Rat Human -DTXSID1045615 Css NA 0.04144 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045615 Css NA 0.4381 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045615 Css NA 0.0615 mg/L PBTK NA 50% Rat Human -DTXSID1045615 Css NA 0.3369 mg/L PBTK NA 95% Rat Human -DTXSID1045619 Clint NA 12.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045619 Fup NA 0.3519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045619 Vd NA 0.5103 L/kg 1compartment NA NA Human Human +DTXSID1045615 TK.Half.Life NA 3.293 hours 1compartment NA NA Rat Human +DTXSID1045615 Css NA 0.02272 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045615 Css NA 0.1181 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045615 Css NA 0.0222 mg/L PBTK NA 50% Rat Human +DTXSID1045615 Css NA 0.09259 mg/L PBTK NA 95% Rat Human +DTXSID1045619 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045619 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045619 Vd NA 0.6156 L/kg 1compartment NA NA Human Human DTXSID1045619 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045619 TK.Half.Life NA 0.7955 hours 1compartment NA NA Human Human -DTXSID1045619 Css NA 0.1069 mg/L 3compartmentss NA 50% Human Human -DTXSID1045619 Css NA 0.746 mg/L 3compartmentss NA 95% Human Human -DTXSID1045619 Css NA 0.0762 mg/L PBTK NA 50% Human Human -DTXSID1045619 Css NA 0.4911 mg/L PBTK NA 95% Human Human -DTXSID1045619 Clint NA 12.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045619 Fup NA 0.3519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045619 Vd NA 0.5109 L/kg 1compartment NA NA Rat Human +DTXSID1045619 TK.Half.Life NA 1.062 hours 1compartment NA NA Human Human +DTXSID1045619 Css NA 0.1278 mg/L 3compartmentss NA 50% Human Human +DTXSID1045619 Css NA 0.9929 mg/L 3compartmentss NA 95% Human Human +DTXSID1045619 Css NA 0.09844 mg/L PBTK NA 50% Human Human +DTXSID1045619 Css NA 0.6596 mg/L PBTK NA 95% Human Human +DTXSID1045619 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045619 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045619 Vd NA 0.6298 L/kg 1compartment NA NA Rat Human DTXSID1045619 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045619 TK.Half.Life NA 0.4346 hours 1compartment NA NA Rat Human -DTXSID1045619 Css NA 0.05639 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045619 Css NA 0.2858 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045619 Css NA 0.03814 mg/L PBTK NA 50% Rat Human -DTXSID1045619 Css NA 0.1775 mg/L PBTK NA 95% Rat Human -DTXSID1045661 Clint NA 34.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045661 Fup NA 0.0822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045661 Vd NA 2.209 L/kg 1compartment NA NA Human Human +DTXSID1045619 TK.Half.Life NA 0.5991 hours 1compartment NA NA Rat Human +DTXSID1045619 Css NA 0.01478 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045619 Css NA 0.08718 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045619 Css NA 0.01142 mg/L PBTK NA 50% Rat Human +DTXSID1045619 Css NA 0.05575 mg/L PBTK NA 95% Rat Human +DTXSID1045661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045661 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045661 Vd NA 4.102 L/kg 1compartment NA NA Human Human DTXSID1045661 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045661 TK.Half.Life NA 3.739 hours 1compartment NA NA Human Human -DTXSID1045661 Css NA 0.1406 mg/L 3compartmentss NA 50% Human Human -DTXSID1045661 Css NA 1.232 mg/L 3compartmentss NA 95% Human Human -DTXSID1045661 Css NA 0.1103 mg/L PBTK NA 50% Human Human -DTXSID1045661 Css NA 0.8645 mg/L PBTK NA 95% Human Human -DTXSID1045661 Clint NA 34.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045661 Fup NA 0.0822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045661 Vd NA 2.095 L/kg 1compartment NA NA Rat Human +DTXSID1045661 TK.Half.Life NA 6.296 hours 1compartment NA NA Human Human +DTXSID1045661 Css NA 0.08399 mg/L 3compartmentss NA 50% Human Human +DTXSID1045661 Css NA 0.6206 mg/L 3compartmentss NA 95% Human Human +DTXSID1045661 Css NA 0.08391 mg/L PBTK NA 50% Human Human +DTXSID1045661 Css NA 0.5531 mg/L PBTK NA 95% Human Human +DTXSID1045661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045661 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045661 Vd NA 3.683 L/kg 1compartment NA NA Rat Human DTXSID1045661 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045661 TK.Half.Life NA 1.956 hours 1compartment NA NA Rat Human -DTXSID1045661 Css NA 0.07858 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045661 Css NA 0.5678 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045661 Css NA 0.05912 mg/L PBTK NA 50% Rat Human -DTXSID1045661 Css NA 0.3702 mg/L PBTK NA 95% Rat Human -DTXSID1045663 Clint NA 112 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045663 Fup NA 0.0866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045663 Vd NA 2.618 L/kg 1compartment NA NA Human Human +DTXSID1045661 TK.Half.Life NA 2.171 hours 1compartment NA NA Rat Human +DTXSID1045661 Css NA 0.01048 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045661 Css NA 0.05901 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045661 Css NA 0.01075 mg/L PBTK NA 50% Rat Human +DTXSID1045661 Css NA 0.05639 mg/L PBTK NA 95% Rat Human +DTXSID1045663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045663 Fup 0.0765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045663 Vd NA 2.801 L/kg 1compartment NA NA Human Human DTXSID1045663 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045663 TK.Half.Life NA 2.07 hours 1compartment NA NA Human Human -DTXSID1045663 Css NA 0.02498 mg/L 3compartmentss NA 50% Human Human -DTXSID1045663 Css NA 0.2477 mg/L 3compartmentss NA 95% Human Human -DTXSID1045663 Css NA 0.02204 mg/L PBTK NA 50% Human Human -DTXSID1045663 Css NA 0.1834 mg/L PBTK NA 95% Human Human -DTXSID1045663 Clint NA 112 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045663 Fup NA 0.0866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045663 Vd NA 2.582 L/kg 1compartment NA NA Rat Human +DTXSID1045663 TK.Half.Life NA 4.266 hours 1compartment NA NA Human Human +DTXSID1045663 Css NA 0.1114 mg/L 3compartmentss NA 50% Human Human +DTXSID1045663 Css NA 1.03 mg/L 3compartmentss NA 95% Human Human +DTXSID1045663 Css NA 0.09838 mg/L PBTK NA 50% Human Human +DTXSID1045663 Css NA 0.7596 mg/L PBTK NA 95% Human Human +DTXSID1045663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045663 Fup 0.0765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045663 Vd NA 2.729 L/kg 1compartment NA NA Rat Human DTXSID1045663 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045663 TK.Half.Life NA 1.012 hours 1compartment NA NA Rat Human -DTXSID1045663 Css NA 0.01414 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045663 Css NA 0.1155 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045663 Css NA 0.0121 mg/L PBTK NA 50% Rat Human -DTXSID1045663 Css NA 0.08164 mg/L PBTK NA 95% Rat Human -DTXSID1045665 Clint NA 2.612 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045665 Fup NA 0.0144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045665 Vd NA 0.3548 L/kg 1compartment NA NA Human Human -DTXSID1045665 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1045665 TK.Half.Life NA 28.47 hours 1compartment NA NA Human Human -DTXSID1045665 Css NA 14.92 mg/L 3compartmentss NA 50% Human Human -DTXSID1045665 Css NA 111.9 mg/L 3compartmentss NA 95% Human Human -DTXSID1045665 Css NA 8.794 mg/L PBTK NA 50% Human Human -DTXSID1045665 Css NA 64.77 mg/L PBTK NA 95% Human Human -DTXSID1045665 Clint NA 2.612 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045665 Fup NA 0.0144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045665 Vd NA 0.2882 L/kg 1compartment NA NA Rat Human -DTXSID1045665 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1045665 TK.Half.Life NA 13.49 hours 1compartment NA NA Rat Human -DTXSID1045665 Css NA 7.171 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045665 Css NA 44.59 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045665 Css NA 3.939 mg/L PBTK NA 50% Rat Human -DTXSID1045665 Css NA 24.22 mg/L PBTK NA 95% Rat Human -DTXSID1045669 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045669 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045669 Vd NA 16.03 L/kg 1compartment NA NA Human Human -DTXSID1045669 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID1045669 TK.Half.Life NA 599100 hours 1compartment NA NA Human Human -DTXSID1045669 Css NA 1720 mg/L 3compartmentss NA 50% Human Human -DTXSID1045669 Css NA 5072 mg/L 3compartmentss NA 95% Human Human -DTXSID1045669 Css NA 2972 mg/L PBTK NA 50% Human Human -DTXSID1045669 Css NA 6952 mg/L PBTK NA 95% Human Human -DTXSID1045669 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045669 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045669 Vd NA 12.88 L/kg 1compartment NA NA Rat Human -DTXSID1045669 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID1045669 TK.Half.Life NA 41280 hours 1compartment NA NA Rat Human -DTXSID1045669 Css NA 433.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045669 Css NA 1039 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045669 Css NA 777.3 mg/L PBTK NA 50% Rat Human -DTXSID1045669 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID1045740 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045740 Fup NA 0.8403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045740 Vd NA 0.7877 L/kg 1compartment NA NA Human Human +DTXSID1045663 TK.Half.Life NA 2.328 hours 1compartment NA NA Rat Human +DTXSID1045663 Css NA 0.01428 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045663 Css NA 0.1083 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045663 Css NA 0.01269 mg/L PBTK NA 50% Rat Human +DTXSID1045663 Css NA 0.08128 mg/L PBTK NA 95% Rat Human +DTXSID1045665 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045665 Fup 0.0387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045665 Vd NA 0.8312 L/kg 1compartment NA NA Human Human +DTXSID1045665 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1045665 TK.Half.Life NA 12.53 hours 1compartment NA NA Human Human +DTXSID1045665 Css NA 2.554 mg/L 3compartmentss NA 50% Human Human +DTXSID1045665 Css NA 19.48 mg/L 3compartmentss NA 95% Human Human +DTXSID1045665 Css NA 1.572 mg/L PBTK NA 50% Human Human +DTXSID1045665 Css NA 11.54 mg/L PBTK NA 95% Human Human +DTXSID1045665 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045665 Fup 0.0387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045665 Vd NA 0.6339 L/kg 1compartment NA NA Rat Human +DTXSID1045665 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1045665 TK.Half.Life NA 5.613 hours 1compartment NA NA Rat Human +DTXSID1045665 Css NA 0.315 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045665 Css NA 1.85 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045665 Css NA 0.1879 mg/L PBTK NA 50% Rat Human +DTXSID1045665 Css NA 1.059 mg/L PBTK NA 95% Rat Human +DTXSID1045669 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045669 Fup 0.0129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045669 Vd NA 4.968 L/kg 1compartment NA NA Human Human +DTXSID1045669 Days.Css NA 26 Days PBTK NA NA Human Human +DTXSID1045669 TK.Half.Life NA 146.7 hours 1compartment NA NA Human Human +DTXSID1045669 Css NA 3.004 mg/L 3compartmentss NA 50% Human Human +DTXSID1045669 Css NA 18.93 mg/L 3compartmentss NA 95% Human Human +DTXSID1045669 Css NA 2.412 mg/L PBTK NA 50% Human Human +DTXSID1045669 Css NA 14.84 mg/L PBTK NA 95% Human Human +DTXSID1045669 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045669 Fup 0.0129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045669 Vd NA 3.794 L/kg 1compartment NA NA Rat Human +DTXSID1045669 Days.Css NA 15 Days PBTK NA NA Rat Human +DTXSID1045669 TK.Half.Life NA 20.23 hours 1compartment NA NA Rat Human +DTXSID1045669 Css NA 0.3839 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045669 Css NA 1.942 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045669 Css NA 0.3123 mg/L PBTK NA 50% Rat Human +DTXSID1045669 Css NA 1.531 mg/L PBTK NA 95% Rat Human +DTXSID1045740 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045740 Fup 0.783 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045740 Vd NA 0.7424 L/kg 1compartment NA NA Human Human DTXSID1045740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045740 TK.Half.Life NA 6.086 hours 1compartment NA NA Human Human -DTXSID1045740 Css NA 0.9586 mg/L 3compartmentss NA 50% Human Human -DTXSID1045740 Css NA 5.834 mg/L 3compartmentss NA 95% Human Human -DTXSID1045740 Css NA 0.7969 mg/L PBTK NA 50% Human Human -DTXSID1045740 Css NA 3.763 mg/L PBTK NA 95% Human Human -DTXSID1045740 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045740 Fup NA 0.8403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045740 Vd NA 0.807 L/kg 1compartment NA NA Rat Human +DTXSID1045740 TK.Half.Life NA 6.134 hours 1compartment NA NA Human Human +DTXSID1045740 Css NA 0.5436 mg/L 3compartmentss NA 50% Human Human +DTXSID1045740 Css NA 3.487 mg/L 3compartmentss NA 95% Human Human +DTXSID1045740 Css NA 0.4536 mg/L PBTK NA 50% Human Human +DTXSID1045740 Css NA 2.303 mg/L PBTK NA 95% Human Human +DTXSID1045740 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045740 Fup 0.783 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045740 Vd NA 0.769 L/kg 1compartment NA NA Rat Human DTXSID1045740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045740 TK.Half.Life NA 2.119 hours 1compartment NA NA Rat Human -DTXSID1045740 Css NA 0.2439 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045740 Css NA 1.392 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045740 Css NA 0.1975 mg/L PBTK NA 50% Rat Human -DTXSID1045740 Css NA 0.84 mg/L PBTK NA 95% Rat Human -DTXSID1045742 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045742 Fup NA 0.0157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045742 Vd NA 0.2058 L/kg 1compartment NA NA Human Human -DTXSID1045742 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID1045742 TK.Half.Life NA 84.81 hours 1compartment NA NA Human Human -DTXSID1045742 Css NA 70.47 mg/L 3compartmentss NA 50% Human Human -DTXSID1045742 Css NA 434.1 mg/L 3compartmentss NA 95% Human Human -DTXSID1045742 Css NA 41.53 mg/L PBTK NA 50% Human Human -DTXSID1045742 Css NA 248.5 mg/L PBTK NA 95% Human Human -DTXSID1045742 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045742 Fup NA 0.0157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045742 Vd NA 0.2007 L/kg 1compartment NA NA Rat Human -DTXSID1045742 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1045742 TK.Half.Life NA 28.19 hours 1compartment NA NA Rat Human -DTXSID1045742 Css NA 20.31 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045742 Css NA 104.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045742 Css NA 11.17 mg/L PBTK NA 50% Rat Human -DTXSID1045742 Css NA 56.71 mg/L PBTK NA 95% Rat Human -DTXSID1045744 Clint NA 18.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045744 Fup NA 0.0374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045744 Vd NA 1.133 L/kg 1compartment NA NA Human Human +DTXSID1045740 TK.Half.Life NA 2.165 hours 1compartment NA NA Rat Human +DTXSID1045740 Css NA 0.002774 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045740 Css NA 0.01881 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045740 Css NA 0.002253 mg/L PBTK NA 50% Rat Human +DTXSID1045740 Css NA 0.01194 mg/L PBTK NA 95% Rat Human +DTXSID1045742 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045742 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045742 Vd NA 0.2679 L/kg 1compartment NA NA Human Human +DTXSID1045742 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045742 TK.Half.Life NA 2.977 hours 1compartment NA NA Human Human +DTXSID1045742 Css NA 1.892 mg/L 3compartmentss NA 50% Human Human +DTXSID1045742 Css NA 19.04 mg/L 3compartmentss NA 95% Human Human +DTXSID1045742 Css NA 1.129 mg/L PBTK NA 50% Human Human +DTXSID1045742 Css NA 11.14 mg/L PBTK NA 95% Human Human +DTXSID1045742 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045742 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045742 Vd NA 0.2529 L/kg 1compartment NA NA Rat Human +DTXSID1045742 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1045742 TK.Half.Life NA 1.856 hours 1compartment NA NA Rat Human +DTXSID1045742 Css NA 0.2483 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045742 Css NA 1.941 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045742 Css NA 0.1438 mg/L PBTK NA 50% Rat Human +DTXSID1045742 Css NA 1.106 mg/L PBTK NA 95% Rat Human +DTXSID1045744 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045744 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045744 Vd NA 2.86 L/kg 1compartment NA NA Human Human DTXSID1045744 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045744 TK.Half.Life NA 4.976 hours 1compartment NA NA Human Human -DTXSID1045744 Css NA 0.6146 mg/L 3compartmentss NA 50% Human Human -DTXSID1045744 Css NA 6.172 mg/L 3compartmentss NA 95% Human Human -DTXSID1045744 Css NA 0.418 mg/L PBTK NA 50% Human Human -DTXSID1045744 Css NA 3.814 mg/L PBTK NA 95% Human Human -DTXSID1045744 Clint NA 18.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045744 Fup NA 0.0374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045744 Vd NA 1.106 L/kg 1compartment NA NA Rat Human +DTXSID1045744 TK.Half.Life NA 9.165 hours 1compartment NA NA Human Human +DTXSID1045744 Css NA 0.2784 mg/L 3compartmentss NA 50% Human Human +DTXSID1045744 Css NA 2.572 mg/L 3compartmentss NA 95% Human Human +DTXSID1045744 Css NA 0.271 mg/L PBTK NA 50% Human Human +DTXSID1045744 Css NA 1.973 mg/L PBTK NA 95% Human Human +DTXSID1045744 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045744 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045744 Vd NA 2.853 L/kg 1compartment NA NA Rat Human DTXSID1045744 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045744 TK.Half.Life NA 3.097 hours 1compartment NA NA Rat Human -DTXSID1045744 Css NA 0.3461 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045744 Css NA 2.674 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045744 Css NA 0.2215 mg/L PBTK NA 50% Rat Human -DTXSID1045744 Css NA 1.564 mg/L PBTK NA 95% Rat Human -DTXSID1045746 Clint NA 7.693 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045746 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045746 Vd NA 0.4209 L/kg 1compartment NA NA Human Human +DTXSID1045744 TK.Half.Life NA 5.581 hours 1compartment NA NA Rat Human +DTXSID1045744 Css NA 0.03394 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045744 Css NA 0.2493 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045744 Css NA 0.03329 mg/L PBTK NA 50% Rat Human +DTXSID1045744 Css NA 0.1812 mg/L PBTK NA 95% Rat Human +DTXSID1045746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045746 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045746 Vd NA 0.3063 L/kg 1compartment NA NA Human Human DTXSID1045746 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045746 TK.Half.Life NA 7.45 hours 1compartment NA NA Human Human -DTXSID1045746 Css NA 3.173 mg/L 3compartmentss NA 50% Human Human -DTXSID1045746 Css NA 26.55 mg/L 3compartmentss NA 95% Human Human -DTXSID1045746 Css NA 1.892 mg/L PBTK NA 50% Human Human -DTXSID1045746 Css NA 15.48 mg/L PBTK NA 95% Human Human -DTXSID1045746 Clint NA 7.693 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045746 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045746 Vd NA 0.3375 L/kg 1compartment NA NA Rat Human +DTXSID1045746 TK.Half.Life NA 0.6296 hours 1compartment NA NA Human Human +DTXSID1045746 Css NA 0.1607 mg/L 3compartmentss NA 50% Human Human +DTXSID1045746 Css NA 1.361 mg/L 3compartmentss NA 95% Human Human +DTXSID1045746 Css NA 0.1002 mg/L PBTK NA 50% Human Human +DTXSID1045746 Css NA 0.8102 mg/L PBTK NA 95% Human Human +DTXSID1045746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045746 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045746 Vd NA 0.2982 L/kg 1compartment NA NA Rat Human DTXSID1045746 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045746 TK.Half.Life NA 3.771 hours 1compartment NA NA Rat Human -DTXSID1045746 Css NA 1.72 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045746 Css NA 11.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045746 Css NA 0.9588 mg/L PBTK NA 50% Rat Human -DTXSID1045746 Css NA 6.216 mg/L PBTK NA 95% Rat Human -DTXSID1045748 Clint NA 1.167 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045748 Fup NA 0.5693 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045748 Vd NA 3.072 L/kg 1compartment NA NA Human Human +DTXSID1045746 TK.Half.Life NA 0.3497 hours 1compartment NA NA Rat Human +DTXSID1045746 Css NA 0.007972 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045746 Css NA 0.07297 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045746 Css NA 0.004752 mg/L PBTK NA 50% Rat Human +DTXSID1045746 Css NA 0.04201 mg/L PBTK NA 95% Rat Human +DTXSID1045748 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045748 Fup 0.676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045748 Vd NA 2.577 L/kg 1compartment NA NA Human Human DTXSID1045748 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045748 TK.Half.Life NA 12.31 hours 1compartment NA NA Human Human -DTXSID1045748 Css NA 0.2964 mg/L 3compartmentss NA 50% Human Human -DTXSID1045748 Css NA 2.677 mg/L 3compartmentss NA 95% Human Human -DTXSID1045748 Css NA 0.3488 mg/L PBTK NA 50% Human Human -DTXSID1045748 Css NA 1.965 mg/L PBTK NA 95% Human Human -DTXSID1045748 Clint NA 1.167 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045748 Fup NA 0.5693 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045748 Vd NA 3.123 L/kg 1compartment NA NA Rat Human +DTXSID1045748 TK.Half.Life NA 3.138 hours 1compartment NA NA Human Human +DTXSID1045748 Css NA 0.06512 mg/L 3compartmentss NA 50% Human Human +DTXSID1045748 Css NA 0.7085 mg/L 3compartmentss NA 95% Human Human +DTXSID1045748 Css NA 0.07056 mg/L PBTK NA 50% Human Human +DTXSID1045748 Css NA 0.5424 mg/L PBTK NA 95% Human Human +DTXSID1045748 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045748 Fup 0.676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045748 Vd NA 2.614 L/kg 1compartment NA NA Rat Human DTXSID1045748 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045748 TK.Half.Life NA 6.296 hours 1compartment NA NA Rat Human -DTXSID1045748 Css NA 0.1166 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045748 Css NA 1.089 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045748 Css NA 0.1369 mg/L PBTK NA 50% Rat Human -DTXSID1045748 Css NA 0.7279 mg/L PBTK NA 95% Rat Human -DTXSID1045790 Clint NA 15.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045790 Fup NA 0.1805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045790 Vd NA 2.272 L/kg 1compartment NA NA Human Human +DTXSID1045748 TK.Half.Life NA 1.768 hours 1compartment NA NA Rat Human +DTXSID1045748 Css NA 0.002874 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045748 Css NA 0.03569 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045748 Css NA 0.003235 mg/L PBTK NA 50% Rat Human +DTXSID1045748 Css NA 0.02718 mg/L PBTK NA 95% Rat Human +DTXSID1045790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045790 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045790 Vd NA 0.9118 L/kg 1compartment NA NA Human Human DTXSID1045790 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045790 TK.Half.Life NA 6.883 hours 1compartment NA NA Human Human -DTXSID1045790 Css NA 0.2822 mg/L 3compartmentss NA 50% Human Human -DTXSID1045790 Css NA 1.697 mg/L 3compartmentss NA 95% Human Human -DTXSID1045790 Css NA 0.2058 mg/L PBTK NA 50% Human Human -DTXSID1045790 Css NA 1.183 mg/L PBTK NA 95% Human Human -DTXSID1045790 Clint NA 15.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045790 Fup NA 0.1805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045790 Vd NA 1.761 L/kg 1compartment NA NA Rat Human +DTXSID1045790 TK.Half.Life NA 1.046 hours 1compartment NA NA Human Human +DTXSID1045790 Css NA 0.05236 mg/L 3compartmentss NA 50% Human Human +DTXSID1045790 Css NA 0.3987 mg/L 3compartmentss NA 95% Human Human +DTXSID1045790 Css NA 0.03958 mg/L PBTK NA 50% Human Human +DTXSID1045790 Css NA 0.2766 mg/L PBTK NA 95% Human Human +DTXSID1045790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045790 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045790 Vd NA 0.8535 L/kg 1compartment NA NA Rat Human DTXSID1045790 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045790 TK.Half.Life NA 2.178 hours 1compartment NA NA Rat Human -DTXSID1045790 Css NA 0.1505 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045790 Css NA 0.6716 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045790 Css NA 0.1057 mg/L PBTK NA 50% Rat Human -DTXSID1045790 Css NA 0.4521 mg/L PBTK NA 95% Rat Human -DTXSID1045792 Clint NA 28.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045792 Fup NA 0.0387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045792 Vd NA 2.451 L/kg 1compartment NA NA Human Human +DTXSID1045790 TK.Half.Life NA 0.5067 hours 1compartment NA NA Rat Human +DTXSID1045790 Css NA 0.006377 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045790 Css NA 0.04059 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045790 Css NA 0.004887 mg/L PBTK NA 50% Rat Human +DTXSID1045790 Css NA 0.0269 mg/L PBTK NA 95% Rat Human +DTXSID1045792 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045792 Fup 0.0467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045792 Vd NA 2.531 L/kg 1compartment NA NA Human Human DTXSID1045792 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1045792 TK.Half.Life NA 13.98 hours 1compartment NA NA Human Human -DTXSID1045792 Css NA 0.7494 mg/L 3compartmentss NA 50% Human Human -DTXSID1045792 Css NA 5.872 mg/L 3compartmentss NA 95% Human Human -DTXSID1045792 Css NA 0.509 mg/L PBTK NA 50% Human Human -DTXSID1045792 Css NA 3.789 mg/L PBTK NA 95% Human Human -DTXSID1045792 Clint NA 28.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045792 Fup NA 0.0387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045792 Vd NA 1.905 L/kg 1compartment NA NA Rat Human +DTXSID1045792 TK.Half.Life NA 16.44 hours 1compartment NA NA Human Human +DTXSID1045792 Css NA 0.805 mg/L 3compartmentss NA 50% Human Human +DTXSID1045792 Css NA 5.837 mg/L 3compartmentss NA 95% Human Human +DTXSID1045792 Css NA 0.5582 mg/L PBTK NA 50% Human Human +DTXSID1045792 Css NA 3.844 mg/L PBTK NA 95% Human Human +DTXSID1045792 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045792 Fup 0.0467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045792 Vd NA 1.975 L/kg 1compartment NA NA Rat Human DTXSID1045792 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045792 TK.Half.Life NA 4.26 hours 1compartment NA NA Rat Human -DTXSID1045792 Css NA 0.4172 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045792 Css NA 2.573 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045792 Css NA 0.2698 mg/L PBTK NA 50% Rat Human -DTXSID1045792 Css NA 1.591 mg/L PBTK NA 95% Rat Human -DTXSID1045794 Clint NA 4.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045794 Fup NA 0.3187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045794 Vd NA 2.379 L/kg 1compartment NA NA Human Human +DTXSID1045792 TK.Half.Life NA 4.864 hours 1compartment NA NA Rat Human +DTXSID1045792 Css NA 0.1038 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045792 Css NA 0.5651 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045792 Css NA 0.07075 mg/L PBTK NA 50% Rat Human +DTXSID1045792 Css NA 0.3764 mg/L PBTK NA 95% Rat Human +DTXSID1045794 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045794 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045794 Vd NA 2.035 L/kg 1compartment NA NA Human Human DTXSID1045794 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045794 TK.Half.Life NA 6.279 hours 1compartment NA NA Human Human -DTXSID1045794 Css NA 0.193 mg/L 3compartmentss NA 50% Human Human -DTXSID1045794 Css NA 1.337 mg/L 3compartmentss NA 95% Human Human -DTXSID1045794 Css NA 0.1937 mg/L PBTK NA 50% Human Human -DTXSID1045794 Css NA 1.044 mg/L PBTK NA 95% Human Human -DTXSID1045794 Clint NA 4.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045794 Fup NA 0.3187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045794 Vd NA 2.391 L/kg 1compartment NA NA Rat Human +DTXSID1045794 TK.Half.Life NA 3.256 hours 1compartment NA NA Human Human +DTXSID1045794 Css NA 0.1034 mg/L 3compartmentss NA 50% Human Human +DTXSID1045794 Css NA 0.8394 mg/L 3compartmentss NA 95% Human Human +DTXSID1045794 Css NA 0.101 mg/L PBTK NA 50% Human Human +DTXSID1045794 Css NA 0.6498 mg/L PBTK NA 95% Human Human +DTXSID1045794 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045794 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045794 Vd NA 2.046 L/kg 1compartment NA NA Rat Human DTXSID1045794 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045794 TK.Half.Life NA 3.685 hours 1compartment NA NA Rat Human -DTXSID1045794 Css NA 0.0939 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045794 Css NA 0.4833 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045794 Css NA 0.09292 mg/L PBTK NA 50% Rat Human -DTXSID1045794 Css NA 0.3634 mg/L PBTK NA 95% Rat Human -DTXSID1045798 Clint NA 28.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045798 Fup NA 0.1069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045798 Vd NA 2.525 L/kg 1compartment NA NA Human Human +DTXSID1045794 TK.Half.Life NA 1.852 hours 1compartment NA NA Rat Human +DTXSID1045794 Css NA 0.01161 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045794 Css NA 0.07954 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045794 Css NA 0.01166 mg/L PBTK NA 50% Rat Human +DTXSID1045794 Css NA 0.05772 mg/L PBTK NA 95% Rat Human +DTXSID1045796 Clint 9.09 NA uL/min/million hepatocytes NA Pradeep 2020 NA Human Human +DTXSID1045796 Fup 0.6823 NA NA Pradeep 2020 NA Human Human +DTXSID1045796 Vd NA 0.8078 L/kg 1compartment NA NA Human Human +DTXSID1045796 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045796 TK.Half.Life NA 0.9193 hours 1compartment NA NA Human Human +DTXSID1045796 Css NA 0.05758 mg/L 3compartmentss NA 50% Human Human +DTXSID1045796 Css NA 0.5893 mg/L 3compartmentss NA 95% Human Human +DTXSID1045796 Css NA 0.04694 mg/L PBTK NA 50% Human Human +DTXSID1045796 Css NA 0.4022 mg/L PBTK NA 95% Human Human +DTXSID1045796 Clint 9.09 NA uL/min/million hepatocytes NA Pradeep 2020 NA Rat Human +DTXSID1045796 Fup 0.6823 NA NA Pradeep 2020 NA Rat Human +DTXSID1045796 Vd NA 0.8046 L/kg 1compartment NA NA Rat Human +DTXSID1045796 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1045796 TK.Half.Life NA 0.4797 hours 1compartment NA NA Rat Human +DTXSID1045796 Css NA 0.001984 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045796 Css NA 0.02427 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045796 Css NA 0.001612 mg/L PBTK NA 50% Rat Human +DTXSID1045796 Css NA 0.016 mg/L PBTK NA 95% Rat Human +DTXSID1045798 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045798 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045798 Vd NA 1.031 L/kg 1compartment NA NA Human Human DTXSID1045798 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045798 TK.Half.Life NA 3.666 hours 1compartment NA NA Human Human -DTXSID1045798 Css NA 0.1054 mg/L 3compartmentss NA 50% Human Human -DTXSID1045798 Css NA 0.9974 mg/L 3compartmentss NA 95% Human Human -DTXSID1045798 Css NA 0.09221 mg/L PBTK NA 50% Human Human -DTXSID1045798 Css NA 0.7287 mg/L PBTK NA 95% Human Human -DTXSID1045798 Clint NA 28.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045798 Fup NA 0.1069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045798 Vd NA 2.499 L/kg 1compartment NA NA Rat Human +DTXSID1045798 TK.Half.Life NA 2.21 hours 1compartment NA NA Human Human +DTXSID1045798 Css NA 0.1735 mg/L 3compartmentss NA 50% Human Human +DTXSID1045798 Css NA 1.537 mg/L 3compartmentss NA 95% Human Human +DTXSID1045798 Css NA 0.121 mg/L PBTK NA 50% Human Human +DTXSID1045798 Css NA 0.9689 mg/L PBTK NA 95% Human Human +DTXSID1045798 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045798 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045798 Vd NA 1.022 L/kg 1compartment NA NA Rat Human DTXSID1045798 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045798 TK.Half.Life NA 2.059 hours 1compartment NA NA Rat Human -DTXSID1045798 Css NA 0.05904 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045798 Css NA 0.4536 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045798 Css NA 0.04955 mg/L PBTK NA 50% Rat Human -DTXSID1045798 Css NA 0.3106 mg/L PBTK NA 95% Rat Human -DTXSID1045871 Clint NA 7.525 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1045798 TK.Half.Life NA 1.291 hours 1compartment NA NA Rat Human +DTXSID1045798 Css NA 0.008303 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045798 Css NA 0.08158 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045798 Css NA 0.005682 mg/L PBTK NA 50% Rat Human +DTXSID1045798 Css NA 0.0498 mg/L PBTK NA 95% Rat Human +DTXSID1045871 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1045871 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1045871 Vd NA 0.212 L/kg 1compartment NA NA Human Human -DTXSID1045871 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID1045871 TK.Half.Life NA 88.96 hours 1compartment NA NA Human Human -DTXSID1045871 Css NA 79.39 mg/L 3compartmentss NA 50% Human Human -DTXSID1045871 Css NA 639.4 mg/L 3compartmentss NA 95% Human Human -DTXSID1045871 Css NA 46.14 mg/L PBTK NA 50% Human Human -DTXSID1045871 Css NA 370.4 mg/L PBTK NA 95% Human Human -DTXSID1045871 Clint NA 7.525 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1045871 Vd NA 0.1692 L/kg 1compartment NA NA Human Human +DTXSID1045871 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1045871 TK.Half.Life NA 28.64 hours 1compartment NA NA Human Human +DTXSID1045871 Css NA 31.58 mg/L 3compartmentss NA 50% Human Human +DTXSID1045871 Css NA 285.4 mg/L 3compartmentss NA 95% Human Human +DTXSID1045871 Css NA 18.3 mg/L PBTK NA 50% Human Human +DTXSID1045871 Css NA 164.9 mg/L PBTK NA 95% Human Human +DTXSID1045871 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1045871 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1045871 Vd NA 0.1882 L/kg 1compartment NA NA Rat Human -DTXSID1045871 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID1045871 TK.Half.Life NA 51.73 hours 1compartment NA NA Rat Human -DTXSID1045871 Css NA 43.52 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045871 Css NA 281.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045871 Css NA 23.6 mg/L PBTK NA 50% Rat Human -DTXSID1045871 Css NA 152.2 mg/L PBTK NA 95% Rat Human +DTXSID1045871 Vd NA 0.1642 L/kg 1compartment NA NA Rat Human +DTXSID1045871 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1045871 TK.Half.Life NA 18.95 hours 1compartment NA NA Rat Human +DTXSID1045871 Css NA 4.212 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045871 Css NA 28.55 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045871 Css NA 2.359 mg/L PBTK NA 50% Rat Human +DTXSID1045871 Css NA 15.98 mg/L PBTK NA 95% Rat Human DTXSID1045873 Clint NA 0.00118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1045873 Fup NA 0.5633 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045873 Vd NA 0.507 L/kg 1compartment NA NA Human Human +DTXSID1045873 Vd NA 0.4865 L/kg 1compartment NA NA Human Human DTXSID1045873 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045873 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human -DTXSID1045873 Css NA 1.353 mg/L 3compartmentss NA 50% Human Human -DTXSID1045873 Css NA 8.753 mg/L 3compartmentss NA 95% Human Human -DTXSID1045873 Css NA 1.022 mg/L PBTK NA 50% Human Human -DTXSID1045873 Css NA 5.405 mg/L PBTK NA 95% Human Human +DTXSID1045873 TK.Half.Life NA 5.492 hours 1compartment NA NA Human Human +DTXSID1045873 Css NA 1.144 mg/L 3compartmentss NA 50% Human Human +DTXSID1045873 Css NA 7.378 mg/L 3compartmentss NA 95% Human Human +DTXSID1045873 Css NA 0.8564 mg/L PBTK NA 50% Human Human +DTXSID1045873 Css NA 4.611 mg/L PBTK NA 95% Human Human DTXSID1045873 Clint NA 0.00118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1045873 Fup NA 0.5633 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045873 Vd NA 0.5407 L/kg 1compartment NA NA Rat Human +DTXSID1045873 Vd NA 0.524 L/kg 1compartment NA NA Rat Human DTXSID1045873 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045873 TK.Half.Life NA 2.111 hours 1compartment NA NA Rat Human -DTXSID1045873 Css NA 0.3634 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045873 Css NA 2.238 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045873 Css NA 0.2609 mg/L PBTK NA 50% Rat Human -DTXSID1045873 Css NA 1.289 mg/L PBTK NA 95% Rat Human +DTXSID1045873 TK.Half.Life NA 2.034 hours 1compartment NA NA Rat Human +DTXSID1045873 Css NA 0.022 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045873 Css NA 0.1838 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045873 Css NA 0.01586 mg/L PBTK NA 50% Rat Human +DTXSID1045873 Css NA 0.1131 mg/L PBTK NA 95% Rat Human DTXSID1045877 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1045877 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045877 Vd NA 0.6694 L/kg 1compartment NA NA Human Human +DTXSID1045877 Vd NA 0.6702 L/kg 1compartment NA NA Human Human DTXSID1045877 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045877 TK.Half.Life NA 4.332 hours 1compartment NA NA Human Human -DTXSID1045877 Css NA 0.854 mg/L 3compartmentss NA 50% Human Human -DTXSID1045877 Css NA 5.584 mg/L 3compartmentss NA 95% Human Human -DTXSID1045877 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID1045877 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID1045877 TK.Half.Life NA 4.338 hours 1compartment NA NA Human Human +DTXSID1045877 Css NA 0.7197 mg/L 3compartmentss NA 50% Human Human +DTXSID1045877 Css NA 5.084 mg/L 3compartmentss NA 95% Human Human +DTXSID1045877 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID1045877 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID1045877 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1045877 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045877 Vd NA 0.7255 L/kg 1compartment NA NA Rat Human +DTXSID1045877 Vd NA 0.7262 L/kg 1compartment NA NA Rat Human DTXSID1045877 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045877 TK.Half.Life NA 1.599 hours 1compartment NA NA Rat Human -DTXSID1045877 Css NA 0.2147 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045877 Css NA 1.342 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045877 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID1045877 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID1045879 Clint NA 0.5786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045879 Fup NA 0.5421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045879 Vd NA 0.3931 L/kg 1compartment NA NA Human Human +DTXSID1045877 TK.Half.Life NA 1.601 hours 1compartment NA NA Rat Human +DTXSID1045877 Css NA 0.01322 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045877 Css NA 0.1006 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045877 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID1045877 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID1045879 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045879 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045879 Vd NA 0.5306 L/kg 1compartment NA NA Human Human DTXSID1045879 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045879 TK.Half.Life NA 2.437 hours 1compartment NA NA Human Human -DTXSID1045879 Css NA 0.7421 mg/L 3compartmentss NA 50% Human Human -DTXSID1045879 Css NA 4.186 mg/L 3compartmentss NA 95% Human Human -DTXSID1045879 Css NA 0.526 mg/L PBTK NA 50% Human Human -DTXSID1045879 Css NA 2.565 mg/L PBTK NA 95% Human Human -DTXSID1045879 Clint NA 0.5786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045879 Fup NA 0.5421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045879 Vd NA 0.4061 L/kg 1compartment NA NA Rat Human +DTXSID1045879 TK.Half.Life NA 4.871 hours 1compartment NA NA Human Human +DTXSID1045879 Css NA 1.122 mg/L 3compartmentss NA 50% Human Human +DTXSID1045879 Css NA 7.012 mg/L 3compartmentss NA 95% Human Human +DTXSID1045879 Css NA 0.8574 mg/L PBTK NA 50% Human Human +DTXSID1045879 Css NA 4.355 mg/L PBTK NA 95% Human Human +DTXSID1045879 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045879 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045879 Vd NA 0.5392 L/kg 1compartment NA NA Rat Human DTXSID1045879 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045879 TK.Half.Life NA 1.131 hours 1compartment NA NA Rat Human -DTXSID1045879 Css NA 0.2687 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045879 Css NA 1.461 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045879 Css NA 0.1811 mg/L PBTK NA 50% Rat Human -DTXSID1045879 Css NA 0.8327 mg/L PBTK NA 95% Rat Human -DTXSID1045900 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045900 Fup NA 0.2066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045900 Vd NA 2.828 L/kg 1compartment NA NA Human Human -DTXSID1045900 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID1045900 TK.Half.Life NA 97.04 hours 1compartment NA NA Human Human -DTXSID1045900 Css NA 2.821 mg/L 3compartmentss NA 50% Human Human -DTXSID1045900 Css NA 12.2 mg/L 3compartmentss NA 95% Human Human -DTXSID1045900 Css NA 2.782 mg/L PBTK NA 50% Human Human -DTXSID1045900 Css NA 9.215 mg/L PBTK NA 95% Human Human -DTXSID1045900 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045900 Fup NA 0.2066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045900 Vd NA 2.789 L/kg 1compartment NA NA Rat Human -DTXSID1045900 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID1045900 TK.Half.Life NA 30.44 hours 1compartment NA NA Rat Human -DTXSID1045900 Css NA 0.7558 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045900 Css NA 2.796 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045900 Css NA 0.7339 mg/L PBTK NA 50% Rat Human -DTXSID1045900 Css NA 1.961 mg/L PBTK NA 95% Rat Human -DTXSID1045902 Clint NA 35.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045902 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045902 Vd NA 0.4095 L/kg 1compartment NA NA Human Human +DTXSID1045879 TK.Half.Life NA 1.686 hours 1compartment NA NA Rat Human +DTXSID1045879 Css NA 0.06708 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045879 Css NA 0.3893 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045879 Css NA 0.05124 mg/L PBTK NA 50% Rat Human +DTXSID1045879 Css NA 0.2351 mg/L PBTK NA 95% Rat Human +DTXSID1045902 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045902 Fup 0.0489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045902 Vd NA 0.8719 L/kg 1compartment NA NA Human Human DTXSID1045902 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045902 TK.Half.Life NA 2.061 hours 1compartment NA NA Human Human -DTXSID1045902 Css NA 0.7752 mg/L 3compartmentss NA 50% Human Human -DTXSID1045902 Css NA 7.731 mg/L 3compartmentss NA 95% Human Human -DTXSID1045902 Css NA 0.4686 mg/L PBTK NA 50% Human Human -DTXSID1045902 Css NA 4.501 mg/L PBTK NA 95% Human Human -DTXSID1045902 Clint NA 35.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045902 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045902 Vd NA 0.3394 L/kg 1compartment NA NA Rat Human +DTXSID1045902 TK.Half.Life NA 3.784 hours 1compartment NA NA Human Human +DTXSID1045902 Css NA 0.5071 mg/L 3compartmentss NA 50% Human Human +DTXSID1045902 Css NA 4.673 mg/L 3compartmentss NA 95% Human Human +DTXSID1045902 Css NA 0.3254 mg/L PBTK NA 50% Human Human +DTXSID1045902 Css NA 2.869 mg/L PBTK NA 95% Human Human +DTXSID1045902 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045902 Fup 0.0489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045902 Vd NA 0.6838 L/kg 1compartment NA NA Rat Human DTXSID1045902 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045902 TK.Half.Life NA 1.083 hours 1compartment NA NA Rat Human -DTXSID1045902 Css NA 0.442 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045902 Css NA 3.492 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045902 Css NA 0.2482 mg/L PBTK NA 50% Rat Human -DTXSID1045902 Css NA 1.923 mg/L PBTK NA 95% Rat Human -DTXSID1045904 Clint NA 262.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045904 Fup NA 0.0551 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045904 Vd NA 1.202 L/kg 1compartment NA NA Human Human +DTXSID1045902 TK.Half.Life NA 1.749 hours 1compartment NA NA Rat Human +DTXSID1045902 Css NA 0.02519 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045902 Css NA 0.2366 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045902 Css NA 0.01566 mg/L PBTK NA 50% Rat Human +DTXSID1045902 Css NA 0.1393 mg/L PBTK NA 95% Rat Human +DTXSID1045904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045904 Fup 0.0729 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045904 Vd NA 1.248 L/kg 1compartment NA NA Human Human DTXSID1045904 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045904 TK.Half.Life NA 1.396 hours 1compartment NA NA Human Human -DTXSID1045904 Css NA 0.04785 mg/L 3compartmentss NA 50% Human Human -DTXSID1045904 Css NA 0.3902 mg/L 3compartmentss NA 95% Human Human -DTXSID1045904 Css NA 0.03017 mg/L PBTK NA 50% Human Human -DTXSID1045904 Css NA 0.2376 mg/L PBTK NA 95% Human Human -DTXSID1045904 Clint NA 262.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045904 Fup NA 0.0551 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045904 Vd NA 0.9124 L/kg 1compartment NA NA Rat Human +DTXSID1045904 TK.Half.Life NA 4.242 hours 1compartment NA NA Human Human +DTXSID1045904 Css NA 0.4034 mg/L 3compartmentss NA 50% Human Human +DTXSID1045904 Css NA 3.195 mg/L 3compartmentss NA 95% Human Human +DTXSID1045904 Css NA 0.2599 mg/L PBTK NA 50% Human Human +DTXSID1045904 Css NA 1.964 mg/L PBTK NA 95% Human Human +DTXSID1045904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045904 Fup 0.0729 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045904 Vd NA 0.9535 L/kg 1compartment NA NA Rat Human DTXSID1045904 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045904 TK.Half.Life NA 0.5026 hours 1compartment NA NA Rat Human -DTXSID1045904 Css NA 0.02726 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045904 Css NA 0.1913 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045904 Css NA 0.01618 mg/L PBTK NA 50% Rat Human -DTXSID1045904 Css NA 0.1103 mg/L PBTK NA 95% Rat Human -DTXSID1045906 Clint NA 8.436 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045906 Fup NA 0.194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045906 Vd NA 1.155 L/kg 1compartment NA NA Human Human +DTXSID1045904 TK.Half.Life NA 1.749 hours 1compartment NA NA Rat Human +DTXSID1045904 Css NA 0.05306 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045904 Css NA 0.321 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045904 Css NA 0.03325 mg/L PBTK NA 50% Rat Human +DTXSID1045904 Css NA 0.1923 mg/L PBTK NA 95% Rat Human +DTXSID1045906 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045906 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045906 Vd NA 1.936 L/kg 1compartment NA NA Human Human DTXSID1045906 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045906 TK.Half.Life NA 3.591 hours 1compartment NA NA Human Human -DTXSID1045906 Css NA 0.2962 mg/L 3compartmentss NA 50% Human Human -DTXSID1045906 Css NA 1.818 mg/L 3compartmentss NA 95% Human Human -DTXSID1045906 Css NA 0.208 mg/L PBTK NA 50% Human Human -DTXSID1045906 Css NA 1.207 mg/L PBTK NA 95% Human Human -DTXSID1045906 Clint NA 8.436 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045906 Fup NA 0.194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045906 Vd NA 0.9347 L/kg 1compartment NA NA Rat Human +DTXSID1045906 TK.Half.Life NA 2.751 hours 1compartment NA NA Human Human +DTXSID1045906 Css NA 0.08226 mg/L 3compartmentss NA 50% Human Human +DTXSID1045906 Css NA 0.5681 mg/L 3compartmentss NA 95% Human Human +DTXSID1045906 Css NA 0.06323 mg/L PBTK NA 50% Human Human +DTXSID1045906 Css NA 0.4121 mg/L PBTK NA 95% Human Human +DTXSID1045906 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045906 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045906 Vd NA 1.532 L/kg 1compartment NA NA Rat Human DTXSID1045906 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045906 TK.Half.Life NA 1.575 hours 1compartment NA NA Rat Human -DTXSID1045906 Css NA 0.1567 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045906 Css NA 0.6873 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045906 Css NA 0.1057 mg/L PBTK NA 50% Rat Human -DTXSID1045906 Css NA 0.4265 mg/L PBTK NA 95% Rat Human -DTXSID1045950 Clint NA 0.9988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045950 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045950 Vd NA 0.7189 L/kg 1compartment NA NA Human Human +DTXSID1045906 TK.Half.Life NA 0.9832 hours 1compartment NA NA Rat Human +DTXSID1045906 Css NA 0.01014 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045906 Css NA 0.05372 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045906 Css NA 0.007897 mg/L PBTK NA 50% Rat Human +DTXSID1045906 Css NA 0.03852 mg/L PBTK NA 95% Rat Human +DTXSID1045950 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045950 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045950 Vd NA 0.728 L/kg 1compartment NA NA Human Human DTXSID1045950 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045950 TK.Half.Life NA 1.897 hours 1compartment NA NA Human Human -DTXSID1045950 Css NA 0.3188 mg/L 3compartmentss NA 50% Human Human -DTXSID1045950 Css NA 2.115 mg/L 3compartmentss NA 95% Human Human -DTXSID1045950 Css NA 0.2622 mg/L PBTK NA 50% Human Human -DTXSID1045950 Css NA 1.421 mg/L PBTK NA 95% Human Human -DTXSID1045950 Clint NA 0.9988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045950 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045950 Vd NA 0.7657 L/kg 1compartment NA NA Rat Human +DTXSID1045950 TK.Half.Life NA 6.527 hours 1compartment NA NA Human Human +DTXSID1045950 Css NA 0.9849 mg/L 3compartmentss NA 50% Human Human +DTXSID1045950 Css NA 6.378 mg/L 3compartmentss NA 95% Human Human +DTXSID1045950 Css NA 0.8397 mg/L PBTK NA 50% Human Human +DTXSID1045950 Css NA 4.184 mg/L PBTK NA 95% Human Human +DTXSID1045950 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045950 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045950 Vd NA 0.7352 L/kg 1compartment NA NA Rat Human DTXSID1045950 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045950 TK.Half.Life NA 0.9684 hours 1compartment NA NA Rat Human -DTXSID1045950 Css NA 0.1193 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045950 Css NA 0.7405 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045950 Css NA 0.09662 mg/L PBTK NA 50% Rat Human -DTXSID1045950 Css NA 0.4439 mg/L PBTK NA 95% Rat Human -DTXSID1045952 Clint NA 2.764 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045952 Fup NA 0.1745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045952 Vd NA 1.232 L/kg 1compartment NA NA Human Human +DTXSID1045950 TK.Half.Life NA 2.245 hours 1compartment NA NA Rat Human +DTXSID1045950 Css NA 0.05904 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045950 Css NA 0.3805 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045950 Css NA 0.05042 mg/L PBTK NA 50% Rat Human +DTXSID1045950 Css NA 0.2365 mg/L PBTK NA 95% Rat Human +DTXSID1045952 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045952 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045952 Vd NA 1.928 L/kg 1compartment NA NA Human Human DTXSID1045952 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045952 TK.Half.Life NA 8.923 hours 1compartment NA NA Human Human -DTXSID1045952 Css NA 0.779 mg/L 3compartmentss NA 50% Human Human -DTXSID1045952 Css NA 4.038 mg/L 3compartmentss NA 95% Human Human -DTXSID1045952 Css NA 0.5762 mg/L PBTK NA 50% Human Human -DTXSID1045952 Css NA 2.666 mg/L PBTK NA 95% Human Human -DTXSID1045952 Clint NA 2.764 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045952 Fup NA 0.1745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045952 Vd NA 1.159 L/kg 1compartment NA NA Rat Human +DTXSID1045952 TK.Half.Life NA 4.618 hours 1compartment NA NA Human Human +DTXSID1045952 Css NA 0.1828 mg/L 3compartmentss NA 50% Human Human +DTXSID1045952 Css NA 1.19 mg/L 3compartmentss NA 95% Human Human +DTXSID1045952 Css NA 0.1582 mg/L PBTK NA 50% Human Human +DTXSID1045952 Css NA 0.8709 mg/L PBTK NA 95% Human Human +DTXSID1045952 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045952 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045952 Vd NA 1.815 L/kg 1compartment NA NA Rat Human DTXSID1045952 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045952 TK.Half.Life NA 4.655 hours 1compartment NA NA Rat Human -DTXSID1045952 Css NA 0.3678 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045952 Css NA 1.409 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045952 Css NA 0.2617 mg/L PBTK NA 50% Rat Human -DTXSID1045952 Css NA 0.8639 mg/L PBTK NA 95% Rat Human -DTXSID1045954 Clint NA 22.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045954 Fup NA 0.4349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045954 Vd NA 1.17 L/kg 1compartment NA NA Human Human -DTXSID1045954 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045954 TK.Half.Life NA 1.173 hours 1compartment NA NA Human Human -DTXSID1045954 Css NA 0.04226 mg/L 3compartmentss NA 50% Human Human -DTXSID1045954 Css NA 0.3652 mg/L 3compartmentss NA 95% Human Human -DTXSID1045954 Css NA 0.03518 mg/L PBTK NA 50% Human Human -DTXSID1045954 Css NA 0.2597 mg/L PBTK NA 95% Human Human -DTXSID1045954 Clint NA 22.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045954 Fup NA 0.4349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045954 Vd NA 1.186 L/kg 1compartment NA NA Rat Human +DTXSID1045952 TK.Half.Life NA 2.367 hours 1compartment NA NA Rat Human +DTXSID1045952 Css NA 0.02123 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045952 Css NA 0.1026 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045952 Css NA 0.01864 mg/L PBTK NA 50% Rat Human +DTXSID1045952 Css NA 0.07522 mg/L PBTK NA 95% Rat Human +DTXSID1045954 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045954 Fup 0.633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045954 Vd NA 1.486 L/kg 1compartment NA NA Human Human +DTXSID1045954 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1045954 TK.Half.Life NA 15.19 hours 1compartment NA NA Human Human +DTXSID1045954 Css NA 0.8674 mg/L 3compartmentss NA 50% Human Human +DTXSID1045954 Css NA 6.54 mg/L 3compartmentss NA 95% Human Human +DTXSID1045954 Css NA 0.8084 mg/L PBTK NA 50% Human Human +DTXSID1045954 Css NA 4.24 mg/L PBTK NA 95% Human Human +DTXSID1045954 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045954 Fup 0.633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045954 Vd NA 1.512 L/kg 1compartment NA NA Rat Human DTXSID1045954 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045954 TK.Half.Life NA 0.6156 hours 1compartment NA NA Rat Human -DTXSID1045954 Css NA 0.02224 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045954 Css NA 0.1529 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045954 Css NA 0.01794 mg/L PBTK NA 50% Rat Human -DTXSID1045954 Css NA 0.1058 mg/L PBTK NA 95% Rat Human -DTXSID1045956 Clint NA 0.5333 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045956 Fup NA 0.0394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045956 Vd NA 0.2343 L/kg 1compartment NA NA Human Human -DTXSID1045956 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1045956 TK.Half.Life NA 20.48 hours 1compartment NA NA Human Human -DTXSID1045956 Css NA 14.96 mg/L 3compartmentss NA 50% Human Human -DTXSID1045956 Css NA 93.06 mg/L 3compartmentss NA 95% Human Human -DTXSID1045956 Css NA 8.972 mg/L PBTK NA 50% Human Human -DTXSID1045956 Css NA 54.61 mg/L PBTK NA 95% Human Human -DTXSID1045956 Clint NA 0.5333 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045956 Fup NA 0.0394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045956 Vd NA 0.2286 L/kg 1compartment NA NA Rat Human +DTXSID1045954 TK.Half.Life NA 5.267 hours 1compartment NA NA Rat Human +DTXSID1045954 Css NA 0.02226 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045954 Css NA 0.1956 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045954 Css NA 0.02069 mg/L PBTK NA 50% Rat Human +DTXSID1045954 Css NA 0.1307 mg/L PBTK NA 95% Rat Human +DTXSID1045956 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045956 Fup 0.0525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045956 Vd NA 0.2255 L/kg 1compartment NA NA Human Human +DTXSID1045956 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1045956 TK.Half.Life NA 2.628 hours 1compartment NA NA Human Human +DTXSID1045956 Css NA 1.695 mg/L 3compartmentss NA 50% Human Human +DTXSID1045956 Css NA 12 mg/L 3compartmentss NA 95% Human Human +DTXSID1045956 Css NA 1.011 mg/L PBTK NA 50% Human Human +DTXSID1045956 Css NA 6.929 mg/L PBTK NA 95% Human Human +DTXSID1045956 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045956 Fup 0.0525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045956 Vd NA 0.2268 L/kg 1compartment NA NA Rat Human DTXSID1045956 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045956 TK.Half.Life NA 8.962 hours 1compartment NA NA Rat Human -DTXSID1045956 Css NA 5.712 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045956 Css NA 29.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045956 Css NA 3.202 mg/L PBTK NA 50% Rat Human -DTXSID1045956 Css NA 16.11 mg/L PBTK NA 95% Rat Human -DTXSID1045958 Clint NA 54.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045958 Fup NA 0.0691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1045958 Vd NA 2.653 L/kg 1compartment NA NA Human Human +DTXSID1045956 TK.Half.Life NA 1.647 hours 1compartment NA NA Rat Human +DTXSID1045956 Css NA 0.07743 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045956 Css NA 0.6133 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045956 Css NA 0.04409 mg/L PBTK NA 50% Rat Human +DTXSID1045956 Css NA 0.3456 mg/L PBTK NA 95% Rat Human +DTXSID1045958 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045958 Fup 0.0557 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1045958 Vd NA 2.277 L/kg 1compartment NA NA Human Human DTXSID1045958 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1045958 TK.Half.Life NA 6.684 hours 1compartment NA NA Human Human -DTXSID1045958 Css NA 0.2282 mg/L 3compartmentss NA 50% Human Human -DTXSID1045958 Css NA 1.633 mg/L 3compartmentss NA 95% Human Human -DTXSID1045958 Css NA 0.1635 mg/L PBTK NA 50% Human Human -DTXSID1045958 Css NA 1.101 mg/L PBTK NA 95% Human Human -DTXSID1045958 Clint NA 54.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045958 Fup NA 0.0691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1045958 Vd NA 2.098 L/kg 1compartment NA NA Rat Human +DTXSID1045958 TK.Half.Life NA 11.15 hours 1compartment NA NA Human Human +DTXSID1045958 Css NA 0.5978 mg/L 3compartmentss NA 50% Human Human +DTXSID1045958 Css NA 4.512 mg/L 3compartmentss NA 95% Human Human +DTXSID1045958 Css NA 0.4132 mg/L PBTK NA 50% Human Human +DTXSID1045958 Css NA 2.942 mg/L PBTK NA 95% Human Human +DTXSID1045958 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045958 Fup 0.0557 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1045958 Vd NA 1.818 L/kg 1compartment NA NA Rat Human DTXSID1045958 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1045958 TK.Half.Life NA 2.045 hours 1compartment NA NA Rat Human -DTXSID1045958 Css NA 0.13 mg/L 3compartmentss NA 50% Rat Human -DTXSID1045958 Css NA 0.6878 mg/L 3compartmentss NA 95% Rat Human -DTXSID1045958 Css NA 0.08892 mg/L PBTK NA 50% Rat Human -DTXSID1045958 Css NA 0.4555 mg/L PBTK NA 95% Rat Human -DTXSID1046003 Clint NA 7.092 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046003 Fup NA 0.1212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046003 Vd NA 1.594 L/kg 1compartment NA NA Human Human +DTXSID1045958 TK.Half.Life NA 3.945 hours 1compartment NA NA Rat Human +DTXSID1045958 Css NA 0.07698 mg/L 3compartmentss NA 50% Rat Human +DTXSID1045958 Css NA 0.4408 mg/L 3compartmentss NA 95% Rat Human +DTXSID1045958 Css NA 0.0526 mg/L PBTK NA 50% Rat Human +DTXSID1045958 Css NA 0.2827 mg/L PBTK NA 95% Rat Human +DTXSID1046003 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046003 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046003 Vd NA 0.6947 L/kg 1compartment NA NA Human Human DTXSID1046003 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046003 TK.Half.Life NA 8.065 hours 1compartment NA NA Human Human -DTXSID1046003 Css NA 0.6217 mg/L 3compartmentss NA 50% Human Human -DTXSID1046003 Css NA 4.482 mg/L 3compartmentss NA 95% Human Human -DTXSID1046003 Css NA 0.4507 mg/L PBTK NA 50% Human Human -DTXSID1046003 Css NA 2.92 mg/L PBTK NA 95% Human Human -DTXSID1046003 Clint NA 7.092 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046003 Fup NA 0.1212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046003 Vd NA 1.42 L/kg 1compartment NA NA Rat Human +DTXSID1046003 TK.Half.Life NA 1.785 hours 1compartment NA NA Human Human +DTXSID1046003 Css NA 0.2254 mg/L 3compartmentss NA 50% Human Human +DTXSID1046003 Css NA 1.419 mg/L 3compartmentss NA 95% Human Human +DTXSID1046003 Css NA 0.1614 mg/L PBTK NA 50% Human Human +DTXSID1046003 Css NA 0.9295 mg/L PBTK NA 95% Human Human +DTXSID1046003 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046003 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046003 Vd NA 0.7037 L/kg 1compartment NA NA Rat Human DTXSID1046003 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046003 TK.Half.Life NA 4.032 hours 1compartment NA NA Rat Human -DTXSID1046003 Css NA 0.3285 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046003 Css NA 1.812 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046003 Css NA 0.2262 mg/L PBTK NA 50% Rat Human -DTXSID1046003 Css NA 1.088 mg/L PBTK NA 95% Rat Human -DTXSID1046007 Clint NA 6.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046007 Fup NA 0.9477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046007 Vd NA 4.516 L/kg 1compartment NA NA Human Human +DTXSID1046003 TK.Half.Life NA 1.037 hours 1compartment NA NA Rat Human +DTXSID1046003 Css NA 0.02667 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046003 Css NA 0.1235 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046003 Css NA 0.01891 mg/L PBTK NA 50% Rat Human +DTXSID1046003 Css NA 0.0792 mg/L PBTK NA 95% Rat Human +DTXSID1046007 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046007 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046007 Vd NA 3.114 L/kg 1compartment NA NA Human Human DTXSID1046007 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046007 TK.Half.Life NA 3.671 hours 1compartment NA NA Human Human -DTXSID1046007 Css NA 0.04331 mg/L 3compartmentss NA 50% Human Human -DTXSID1046007 Css NA 0.2905 mg/L 3compartmentss NA 95% Human Human -DTXSID1046007 Css NA 0.06058 mg/L PBTK NA 50% Human Human -DTXSID1046007 Css NA 0.3231 mg/L PBTK NA 95% Human Human -DTXSID1046007 Clint NA 6.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046007 Fup NA 0.9477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046007 Vd NA 4.608 L/kg 1compartment NA NA Rat Human +DTXSID1046007 TK.Half.Life NA 2.288 hours 1compartment NA NA Human Human +DTXSID1046007 Css NA 0.02386 mg/L 3compartmentss NA 50% Human Human +DTXSID1046007 Css NA 0.2609 mg/L 3compartmentss NA 95% Human Human +DTXSID1046007 Css NA 0.02785 mg/L PBTK NA 50% Human Human +DTXSID1046007 Css NA 0.2288 mg/L PBTK NA 95% Human Human +DTXSID1046007 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046007 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046007 Vd NA 3.154 L/kg 1compartment NA NA Rat Human DTXSID1046007 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046007 TK.Half.Life NA 2.083 hours 1compartment NA NA Rat Human -DTXSID1046007 Css NA 0.01961 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046007 Css NA 0.1091 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046007 Css NA 0.02906 mg/L PBTK NA 50% Rat Human -DTXSID1046007 Css NA 0.1163 mg/L PBTK NA 95% Rat Human -DTXSID1046009 Clint NA 3426 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046009 Fup NA 0.0893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046009 Vd NA 1.056 L/kg 1compartment NA NA Human Human -DTXSID1046009 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046009 TK.Half.Life NA 0.8975 hours 1compartment NA NA Human Human -DTXSID1046009 Css NA 0.00206 mg/L 3compartmentss NA 50% Human Human -DTXSID1046009 Css NA 0.01822 mg/L 3compartmentss NA 95% Human Human -DTXSID1046009 Css NA 0.001359 mg/L PBTK NA 50% Human Human -DTXSID1046009 Css NA 0.01149 mg/L PBTK NA 95% Human Human -DTXSID1046009 Clint NA 3426 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046009 Fup NA 0.0893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046009 Vd NA 0.9298 L/kg 1compartment NA NA Rat Human -DTXSID1046009 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046009 TK.Half.Life NA 0.348 hours 1compartment NA NA Rat Human -DTXSID1046009 Css NA 0.001176 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046009 Css NA 0.008834 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046009 Css NA 0.0007315 mg/L PBTK NA 50% Rat Human -DTXSID1046009 Css NA 0.005198 mg/L PBTK NA 95% Rat Human +DTXSID1046007 TK.Half.Life NA 1.23 hours 1compartment NA NA Rat Human +DTXSID1046007 Css NA 0.002856 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046007 Css NA 0.02756 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046007 Css NA 0.003501 mg/L PBTK NA 50% Rat Human +DTXSID1046007 Css NA 0.02256 mg/L PBTK NA 95% Rat Human DTXSID1046051 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046051 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046051 Vd NA 0.6978 L/kg 1compartment NA NA Human Human +DTXSID1046051 Vd NA 0.6753 L/kg 1compartment NA NA Human Human DTXSID1046051 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046051 TK.Half.Life NA 4.516 hours 1compartment NA NA Human Human -DTXSID1046051 Css NA 0.8472 mg/L 3compartmentss NA 50% Human Human -DTXSID1046051 Css NA 5.575 mg/L 3compartmentss NA 95% Human Human -DTXSID1046051 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID1046051 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID1046051 TK.Half.Life NA 4.37 hours 1compartment NA NA Human Human +DTXSID1046051 Css NA 0.7226 mg/L 3compartmentss NA 50% Human Human +DTXSID1046051 Css NA 5.093 mg/L 3compartmentss NA 95% Human Human +DTXSID1046051 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID1046051 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID1046051 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046051 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046051 Vd NA 0.7483 L/kg 1compartment NA NA Rat Human +DTXSID1046051 Vd NA 0.7232 L/kg 1compartment NA NA Rat Human DTXSID1046051 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046051 TK.Half.Life NA 1.65 hours 1compartment NA NA Rat Human -DTXSID1046051 Css NA 0.2128 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046051 Css NA 1.339 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046051 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID1046051 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID1046055 Clint NA 361.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046055 Fup NA 0.0338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046055 Vd NA 2.822 L/kg 1compartment NA NA Human Human -DTXSID1046055 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046055 TK.Half.Life NA 4.295 hours 1compartment NA NA Human Human -DTXSID1046055 Css NA 0.09546 mg/L 3compartmentss NA 50% Human Human -DTXSID1046055 Css NA 0.641 mg/L 3compartmentss NA 95% Human Human -DTXSID1046055 Css NA 0.06543 mg/L PBTK NA 50% Human Human -DTXSID1046055 Css NA 0.4287 mg/L PBTK NA 95% Human Human -DTXSID1046055 Clint NA 361.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046055 Fup NA 0.0338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046055 Vd NA 2.113 L/kg 1compartment NA NA Rat Human -DTXSID1046055 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046055 TK.Half.Life NA 1.133 hours 1compartment NA NA Rat Human -DTXSID1046055 Css NA 0.0548 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046055 Css NA 0.2981 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046055 Css NA 0.0354 mg/L PBTK NA 50% Rat Human -DTXSID1046055 Css NA 0.1858 mg/L PBTK NA 95% Rat Human -DTXSID1046059 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046059 Fup NA 0.0806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046059 Vd NA 0.3239 L/kg 1compartment NA NA Human Human +DTXSID1046051 TK.Half.Life NA 1.595 hours 1compartment NA NA Rat Human +DTXSID1046051 Css NA 0.01328 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046051 Css NA 0.1009 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046051 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID1046051 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID10460510 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10460510 Fup 0.0202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10460510 Vd NA 3.021 L/kg 1compartment NA NA Human Human +DTXSID10460510 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID10460510 TK.Half.Life NA 63.71 hours 1compartment NA NA Human Human +DTXSID10460510 Css NA 2.582 mg/L 3compartmentss NA 50% Human Human +DTXSID10460510 Css NA 17.09 mg/L 3compartmentss NA 95% Human Human +DTXSID10460510 Css NA 1.779 mg/L PBTK NA 50% Human Human +DTXSID10460510 Css NA 11.34 mg/L PBTK NA 95% Human Human +DTXSID10460510 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10460510 Fup 0.0202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10460510 Vd NA 2.262 L/kg 1compartment NA NA Rat Human +DTXSID10460510 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID10460510 TK.Half.Life NA 9.874 hours 1compartment NA NA Rat Human +DTXSID10460510 Css NA 0.3357 mg/L 3compartmentss NA 50% Rat Human +DTXSID10460510 Css NA 1.929 mg/L 3compartmentss NA 95% Rat Human +DTXSID10460510 Css NA 0.228 mg/L PBTK NA 50% Rat Human +DTXSID10460510 Css NA 1.281 mg/L PBTK NA 95% Rat Human +DTXSID1046055 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046055 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046055 Vd NA 3 L/kg 1compartment NA NA Human Human +DTXSID1046055 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID1046055 TK.Half.Life NA 52.39 hours 1compartment NA NA Human Human +DTXSID1046055 Css NA 2.155 mg/L 3compartmentss NA 50% Human Human +DTXSID1046055 Css NA 14.4 mg/L 3compartmentss NA 95% Human Human +DTXSID1046055 Css NA 1.481 mg/L PBTK NA 50% Human Human +DTXSID1046055 Css NA 9.617 mg/L PBTK NA 95% Human Human +DTXSID1046055 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046055 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046055 Vd NA 2.247 L/kg 1compartment NA NA Rat Human +DTXSID1046055 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID1046055 TK.Half.Life NA 8.397 hours 1compartment NA NA Rat Human +DTXSID1046055 Css NA 0.2766 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046055 Css NA 1.547 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046055 Css NA 0.1881 mg/L PBTK NA 50% Rat Human +DTXSID1046055 Css NA 1.021 mg/L PBTK NA 95% Rat Human +DTXSID1046059 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046059 Fup 0.0937 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046059 Vd NA 0.3454 L/kg 1compartment NA NA Human Human DTXSID1046059 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046059 TK.Half.Life NA 1.653 hours 1compartment NA NA Human Human -DTXSID1046059 Css NA 0.74 mg/L 3compartmentss NA 50% Human Human -DTXSID1046059 Css NA 5.34 mg/L 3compartmentss NA 95% Human Human -DTXSID1046059 Css NA 0.4617 mg/L PBTK NA 50% Human Human -DTXSID1046059 Css NA 3.171 mg/L PBTK NA 95% Human Human -DTXSID1046059 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046059 Fup NA 0.0806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046059 Vd NA 0.3164 L/kg 1compartment NA NA Rat Human +DTXSID1046059 TK.Half.Life NA 0.9338 hours 1compartment NA NA Human Human +DTXSID1046059 Css NA 0.302 mg/L 3compartmentss NA 50% Human Human +DTXSID1046059 Css NA 2.511 mg/L 3compartmentss NA 95% Human Human +DTXSID1046059 Css NA 0.191 mg/L PBTK NA 50% Human Human +DTXSID1046059 Css NA 1.519 mg/L PBTK NA 95% Human Human +DTXSID1046059 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046059 Fup 0.0937 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046059 Vd NA 0.3378 L/kg 1compartment NA NA Rat Human DTXSID1046059 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046059 TK.Half.Life NA 1.004 hours 1compartment NA NA Rat Human -DTXSID1046059 Css NA 0.4038 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046059 Css NA 2.236 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046059 Css NA 0.2374 mg/L PBTK NA 50% Rat Human -DTXSID1046059 Css NA 1.259 mg/L PBTK NA 95% Rat Human -DTXSID1046130 Clint NA 15.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046130 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046130 Vd NA 1.474 L/kg 1compartment NA NA Human Human +DTXSID1046059 TK.Half.Life NA 0.5471 hours 1compartment NA NA Rat Human +DTXSID1046059 Css NA 0.04 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046059 Css NA 0.2518 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046059 Css NA 0.02475 mg/L PBTK NA 50% Rat Human +DTXSID1046059 Css NA 0.1468 mg/L PBTK NA 95% Rat Human +DTXSID1046130 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046130 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046130 Vd NA 1.461 L/kg 1compartment NA NA Human Human DTXSID1046130 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046130 TK.Half.Life NA 1.622 hours 1compartment NA NA Human Human -DTXSID1046130 Css NA 0.05617 mg/L 3compartmentss NA 50% Human Human -DTXSID1046130 Css NA 0.5079 mg/L 3compartmentss NA 95% Human Human -DTXSID1046130 Css NA 0.0472 mg/L PBTK NA 50% Human Human -DTXSID1046130 Css NA 0.3734 mg/L PBTK NA 95% Human Human -DTXSID1046130 Clint NA 15.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046130 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046130 Vd NA 1.258 L/kg 1compartment NA NA Rat Human +DTXSID1046130 TK.Half.Life NA 1.428 hours 1compartment NA NA Human Human +DTXSID1046130 Css NA 0.03897 mg/L 3compartmentss NA 50% Human Human +DTXSID1046130 Css NA 0.3581 mg/L 3compartmentss NA 95% Human Human +DTXSID1046130 Css NA 0.03251 mg/L PBTK NA 50% Human Human +DTXSID1046130 Css NA 0.2533 mg/L PBTK NA 95% Human Human +DTXSID1046130 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046130 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046130 Vd NA 1.248 L/kg 1compartment NA NA Rat Human DTXSID1046130 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046130 TK.Half.Life NA 0.6789 hours 1compartment NA NA Rat Human -DTXSID1046130 Css NA 0.02939 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046130 Css NA 0.2068 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046130 Css NA 0.0241 mg/L PBTK NA 50% Rat Human -DTXSID1046130 Css NA 0.1413 mg/L PBTK NA 95% Rat Human +DTXSID1046130 TK.Half.Life NA 0.5889 hours 1compartment NA NA Rat Human +DTXSID1046130 Css NA 0.004782 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046130 Css NA 0.03503 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046130 Css NA 0.004055 mg/L PBTK NA 50% Rat Human +DTXSID1046130 Css NA 0.02526 mg/L PBTK NA 95% Rat Human DTXSID1046132 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046132 Fup NA 0.4989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046132 Vd NA 0.432 L/kg 1compartment NA NA Human Human +DTXSID1046132 Vd NA 0.4589 L/kg 1compartment NA NA Human Human DTXSID1046132 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046132 TK.Half.Life NA 5.603 hours 1compartment NA NA Human Human -DTXSID1046132 Css NA 1.526 mg/L 3compartmentss NA 50% Human Human -DTXSID1046132 Css NA 7.682 mg/L 3compartmentss NA 95% Human Human -DTXSID1046132 Css NA 1.106 mg/L PBTK NA 50% Human Human -DTXSID1046132 Css NA 4.767 mg/L PBTK NA 95% Human Human +DTXSID1046132 TK.Half.Life NA 5.95 hours 1compartment NA NA Human Human +DTXSID1046132 Css NA 1.279 mg/L 3compartmentss NA 50% Human Human +DTXSID1046132 Css NA 6.503 mg/L 3compartmentss NA 95% Human Human +DTXSID1046132 Css NA 0.9392 mg/L PBTK NA 50% Human Human +DTXSID1046132 Css NA 4.071 mg/L PBTK NA 95% Human Human DTXSID1046132 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046132 Fup NA 0.4989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046132 Vd NA 0.4481 L/kg 1compartment NA NA Rat Human +DTXSID1046132 Vd NA 0.4922 L/kg 1compartment NA NA Rat Human DTXSID1046132 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046132 TK.Half.Life NA 1.981 hours 1compartment NA NA Rat Human -DTXSID1046132 Css NA 0.4128 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046132 Css NA 1.831 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046132 Css NA 0.2856 mg/L PBTK NA 50% Rat Human -DTXSID1046132 Css NA 1.064 mg/L PBTK NA 95% Rat Human -DTXSID1046134 Clint NA 9.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046134 Fup NA 0.0029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046134 Vd NA 0.822 L/kg 1compartment NA NA Human Human -DTXSID1046134 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID1046134 TK.Half.Life NA 72.49 hours 1compartment NA NA Human Human -DTXSID1046134 Css NA 16.35 mg/L 3compartmentss NA 50% Human Human -DTXSID1046134 Css NA 112.2 mg/L 3compartmentss NA 95% Human Human -DTXSID1046134 Css NA 9.722 mg/L PBTK NA 50% Human Human -DTXSID1046134 Css NA 66.02 mg/L PBTK NA 95% Human Human -DTXSID1046134 Clint NA 9.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046134 Fup NA 0.0029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046134 Vd NA 0.6018 L/kg 1compartment NA NA Rat Human -DTXSID1046134 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID1046134 TK.Half.Life NA 32.74 hours 1compartment NA NA Rat Human -DTXSID1046134 Css NA 9.372 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046134 Css NA 46.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046134 Css NA 5.194 mg/L PBTK NA 50% Rat Human -DTXSID1046134 Css NA 25.33 mg/L PBTK NA 95% Rat Human -DTXSID1046136 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046136 Fup NA 0.1442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046136 Vd NA 0.3319 L/kg 1compartment NA NA Human Human -DTXSID1046136 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1046136 TK.Half.Life NA 14.91 hours 1compartment NA NA Human Human -DTXSID1046136 Css NA 6.496 mg/L 3compartmentss NA 50% Human Human -DTXSID1046136 Css NA 29.68 mg/L 3compartmentss NA 95% Human Human -DTXSID1046136 Css NA 4.167 mg/L PBTK NA 50% Human Human -DTXSID1046136 Css NA 17.46 mg/L PBTK NA 95% Human Human -DTXSID1046136 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046136 Fup NA 0.1442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046136 Vd NA 0.3253 L/kg 1compartment NA NA Rat Human +DTXSID1046132 TK.Half.Life NA 2.176 hours 1compartment NA NA Rat Human +DTXSID1046132 Css NA 0.02387 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046132 Css NA 0.165 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046132 Css NA 0.01689 mg/L PBTK NA 50% Rat Human +DTXSID1046132 Css NA 0.1032 mg/L PBTK NA 95% Rat Human +DTXSID1046134 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046134 Fup 0.00556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046134 Vd NA 1.643 L/kg 1compartment NA NA Human Human +DTXSID1046134 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1046134 TK.Half.Life NA 35.53 hours 1compartment NA NA Human Human +DTXSID1046134 Css NA 3.566 mg/L 3compartmentss NA 50% Human Human +DTXSID1046134 Css NA 31.44 mg/L 3compartmentss NA 95% Human Human +DTXSID1046134 Css NA 2.223 mg/L PBTK NA 50% Human Human +DTXSID1046134 Css NA 18.99 mg/L PBTK NA 95% Human Human +DTXSID1046134 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046134 Fup 0.00556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046134 Vd NA 1.209 L/kg 1compartment NA NA Rat Human +DTXSID1046134 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1046134 TK.Half.Life NA 13.04 hours 1compartment NA NA Rat Human +DTXSID1046134 Css NA 0.4651 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046134 Css NA 3.422 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046134 Css NA 0.2815 mg/L PBTK NA 50% Rat Human +DTXSID1046134 Css NA 1.979 mg/L PBTK NA 95% Rat Human +DTXSID1046136 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046136 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046136 Vd NA 0.3198 L/kg 1compartment NA NA Human Human +DTXSID1046136 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046136 TK.Half.Life NA 1.626 hours 1compartment NA NA Human Human +DTXSID1046136 Css NA 0.3584 mg/L 3compartmentss NA 50% Human Human +DTXSID1046136 Css NA 2.773 mg/L 3compartmentss NA 95% Human Human +DTXSID1046136 Css NA 0.2282 mg/L PBTK NA 50% Human Human +DTXSID1046136 Css NA 1.662 mg/L PBTK NA 95% Human Human +DTXSID1046136 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046136 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046136 Vd NA 0.3131 L/kg 1compartment NA NA Rat Human DTXSID1046136 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046136 TK.Half.Life NA 4.976 hours 1compartment NA NA Rat Human -DTXSID1046136 Css NA 1.815 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046136 Css NA 6.878 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046136 Css NA 1.089 mg/L PBTK NA 50% Rat Human -DTXSID1046136 Css NA 3.832 mg/L PBTK NA 95% Rat Human -DTXSID1046138 Clint NA 1.047 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046138 Fup NA 0.0394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046138 Vd NA 0.2318 L/kg 1compartment NA NA Human Human -DTXSID1046138 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1046138 TK.Half.Life NA 13.96 hours 1compartment NA NA Human Human -DTXSID1046138 Css NA 10.56 mg/L 3compartmentss NA 50% Human Human -DTXSID1046138 Css NA 68.63 mg/L 3compartmentss NA 95% Human Human -DTXSID1046138 Css NA 6.272 mg/L PBTK NA 50% Human Human -DTXSID1046138 Css NA 40.37 mg/L PBTK NA 95% Human Human -DTXSID1046138 Clint NA 1.047 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046138 Fup NA 0.0394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046138 Vd NA 0.2218 L/kg 1compartment NA NA Rat Human +DTXSID1046136 TK.Half.Life NA 0.9582 hours 1compartment NA NA Rat Human +DTXSID1046136 Css NA 0.003696 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046136 Css NA 0.02346 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046136 Css NA 0.002197 mg/L PBTK NA 50% Rat Human +DTXSID1046136 Css NA 0.01345 mg/L PBTK NA 95% Rat Human +DTXSID1046138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046138 Fup 0.0724 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046138 Vd NA 0.2914 L/kg 1compartment NA NA Human Human +DTXSID1046138 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046138 TK.Half.Life NA 0.9546 hours 1compartment NA NA Human Human +DTXSID1046138 Css NA 0.4127 mg/L 3compartmentss NA 50% Human Human +DTXSID1046138 Css NA 3.244 mg/L 3compartmentss NA 95% Human Human +DTXSID1046138 Css NA 0.2516 mg/L PBTK NA 50% Human Human +DTXSID1046138 Css NA 1.903 mg/L PBTK NA 95% Human Human +DTXSID1046138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046138 Fup 0.0724 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046138 Vd NA 0.2754 L/kg 1compartment NA NA Rat Human DTXSID1046138 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046138 TK.Half.Life NA 6.736 hours 1compartment NA NA Rat Human -DTXSID1046138 Css NA 4.536 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046138 Css NA 23.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046138 Css NA 2.52 mg/L PBTK NA 50% Rat Human -DTXSID1046138 Css NA 12.94 mg/L PBTK NA 95% Rat Human -DTXSID1046180 Clint NA 85.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046180 Fup NA 0.0284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046180 Vd NA 2.679 L/kg 1compartment NA NA Human Human -DTXSID1046180 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046180 TK.Half.Life NA 9.631 hours 1compartment NA NA Human Human -DTXSID1046180 Css NA 0.4032 mg/L 3compartmentss NA 50% Human Human -DTXSID1046180 Css NA 2.821 mg/L 3compartmentss NA 95% Human Human -DTXSID1046180 Css NA 0.2699 mg/L PBTK NA 50% Human Human -DTXSID1046180 Css NA 1.829 mg/L PBTK NA 95% Human Human -DTXSID1046180 Clint NA 85.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046180 Fup NA 0.0284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046180 Vd NA 2.004 L/kg 1compartment NA NA Rat Human -DTXSID1046180 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046180 TK.Half.Life NA 2.304 hours 1compartment NA NA Rat Human -DTXSID1046180 Css NA 0.2264 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046180 Css NA 1.339 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046180 Css NA 0.1447 mg/L PBTK NA 50% Rat Human -DTXSID1046180 Css NA 0.8291 mg/L PBTK NA 95% Rat Human -DTXSID1046182 Clint NA 84.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046182 Fup NA 0.1659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046182 Vd NA 0.7467 L/kg 1compartment NA NA Human Human +DTXSID1046138 TK.Half.Life NA 0.5501 hours 1compartment NA NA Rat Human +DTXSID1046138 Css NA 0.05422 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046138 Css NA 0.3316 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046138 Css NA 0.03213 mg/L PBTK NA 50% Rat Human +DTXSID1046138 Css NA 0.1904 mg/L PBTK NA 95% Rat Human +DTXSID1046180 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046180 Fup 0.0536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046180 Vd NA 2.579 L/kg 1compartment NA NA Human Human +DTXSID1046180 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID1046180 TK.Half.Life NA 57.47 hours 1compartment NA NA Human Human +DTXSID1046180 Css NA 2.973 mg/L 3compartmentss NA 50% Human Human +DTXSID1046180 Css NA 17.69 mg/L 3compartmentss NA 95% Human Human +DTXSID1046180 Css NA 2.01 mg/L PBTK NA 50% Human Human +DTXSID1046180 Css NA 11.52 mg/L PBTK NA 95% Human Human +DTXSID1046180 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046180 Fup 0.0536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046180 Vd NA 1.933 L/kg 1compartment NA NA Rat Human +DTXSID1046180 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID1046180 TK.Half.Life NA 13.02 hours 1compartment NA NA Rat Human +DTXSID1046180 Css NA 0.3703 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046180 Css NA 1.616 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046180 Css NA 0.2468 mg/L PBTK NA 50% Rat Human +DTXSID1046180 Css NA 1.031 mg/L PBTK NA 95% Rat Human +DTXSID1046182 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046182 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046182 Vd NA 1.082 L/kg 1compartment NA NA Human Human DTXSID1046182 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046182 TK.Half.Life NA 0.8116 hours 1compartment NA NA Human Human -DTXSID1046182 Css NA 0.03564 mg/L 3compartmentss NA 50% Human Human -DTXSID1046182 Css NA 0.2744 mg/L 3compartmentss NA 95% Human Human -DTXSID1046182 Css NA 0.02422 mg/L PBTK NA 50% Human Human -DTXSID1046182 Css NA 0.1782 mg/L PBTK NA 95% Human Human -DTXSID1046182 Clint NA 84.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046182 Fup NA 0.1659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046182 Vd NA 0.6613 L/kg 1compartment NA NA Rat Human +DTXSID1046182 TK.Half.Life NA 2.261 hours 1compartment NA NA Human Human +DTXSID1046182 Css NA 0.1641 mg/L 3compartmentss NA 50% Human Human +DTXSID1046182 Css NA 1.09 mg/L 3compartmentss NA 95% Human Human +DTXSID1046182 Css NA 0.1289 mg/L PBTK NA 50% Human Human +DTXSID1046182 Css NA 0.7589 mg/L PBTK NA 95% Human Human +DTXSID1046182 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046182 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046182 Vd NA 0.987 L/kg 1compartment NA NA Rat Human DTXSID1046182 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046182 TK.Half.Life NA 0.354 hours 1compartment NA NA Rat Human -DTXSID1046182 Css NA 0.01994 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046182 Css NA 0.1183 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046182 Css NA 0.01286 mg/L PBTK NA 50% Rat Human -DTXSID1046182 Css NA 0.07323 mg/L PBTK NA 95% Rat Human -DTXSID1046186 Clint NA 9.371 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046186 Fup NA 0.353 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046186 Vd NA 3.337 L/kg 1compartment NA NA Human Human +DTXSID1046182 TK.Half.Life NA 1.129 hours 1compartment NA NA Rat Human +DTXSID1046182 Css NA 0.01858 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046182 Css NA 0.09663 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046182 Css NA 0.01464 mg/L PBTK NA 50% Rat Human +DTXSID1046182 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID1046186 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046186 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046186 Vd NA 3.245 L/kg 1compartment NA NA Human Human DTXSID1046186 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046186 TK.Half.Life NA 6.743 hours 1compartment NA NA Human Human -DTXSID1046186 Css NA 0.1386 mg/L 3compartmentss NA 50% Human Human -DTXSID1046186 Css NA 0.9063 mg/L 3compartmentss NA 95% Human Human -DTXSID1046186 Css NA 0.1364 mg/L PBTK NA 50% Human Human -DTXSID1046186 Css NA 0.7739 mg/L PBTK NA 95% Human Human -DTXSID1046186 Clint NA 9.371 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046186 Fup NA 0.353 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046186 Vd NA 3.039 L/kg 1compartment NA NA Rat Human +DTXSID1046186 TK.Half.Life NA 9.646 hours 1compartment NA NA Human Human +DTXSID1046186 Css NA 0.2248 mg/L 3compartmentss NA 50% Human Human +DTXSID1046186 Css NA 1.372 mg/L 3compartmentss NA 95% Human Human +DTXSID1046186 Css NA 0.2147 mg/L PBTK NA 50% Human Human +DTXSID1046186 Css NA 1.116 mg/L PBTK NA 95% Human Human +DTXSID1046186 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046186 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046186 Vd NA 2.932 L/kg 1compartment NA NA Rat Human DTXSID1046186 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046186 TK.Half.Life NA 2.753 hours 1compartment NA NA Rat Human -DTXSID1046186 Css NA 0.07158 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046186 Css NA 0.3548 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046186 Css NA 0.06946 mg/L PBTK NA 50% Rat Human -DTXSID1046186 Css NA 0.2858 mg/L PBTK NA 95% Rat Human -DTXSID1046188 Clint NA 50.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046188 Fup NA 0.1903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046188 Vd NA 0.6529 L/kg 1compartment NA NA Human Human +DTXSID1046186 TK.Half.Life NA 3.836 hours 1compartment NA NA Rat Human +DTXSID1046186 Css NA 0.02578 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046186 Css NA 0.1151 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046186 Css NA 0.02526 mg/L PBTK NA 50% Rat Human +DTXSID1046186 Css NA 0.09607 mg/L PBTK NA 95% Rat Human +DTXSID1046188 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046188 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046188 Vd NA 0.609 L/kg 1compartment NA NA Human Human DTXSID1046188 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046188 TK.Half.Life NA 0.7873 hours 1compartment NA NA Human Human -DTXSID1046188 Css NA 0.05276 mg/L 3compartmentss NA 50% Human Human -DTXSID1046188 Css NA 0.3848 mg/L 3compartmentss NA 95% Human Human -DTXSID1046188 Css NA 0.03562 mg/L PBTK NA 50% Human Human -DTXSID1046188 Css NA 0.2475 mg/L PBTK NA 95% Human Human -DTXSID1046188 Clint NA 50.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046188 Fup NA 0.1903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046188 Vd NA 0.5775 L/kg 1compartment NA NA Rat Human +DTXSID1046188 TK.Half.Life NA 2.504 hours 1compartment NA NA Human Human +DTXSID1046188 Css NA 0.4626 mg/L 3compartmentss NA 50% Human Human +DTXSID1046188 Css NA 2.764 mg/L 3compartmentss NA 95% Human Human +DTXSID1046188 Css NA 0.3072 mg/L PBTK NA 50% Human Human +DTXSID1046188 Css NA 1.731 mg/L PBTK NA 95% Human Human +DTXSID1046188 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046188 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046188 Vd NA 0.5384 L/kg 1compartment NA NA Rat Human DTXSID1046188 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046188 TK.Half.Life NA 0.3551 hours 1compartment NA NA Rat Human -DTXSID1046188 Css NA 0.02914 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046188 Css NA 0.1633 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046188 Css NA 0.01879 mg/L PBTK NA 50% Rat Human -DTXSID1046188 Css NA 0.1013 mg/L PBTK NA 95% Rat Human -DTXSID1046211 Clint NA 1.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046211 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046211 Vd NA 0.2291 L/kg 1compartment NA NA Human Human -DTXSID1046211 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1046211 TK.Half.Life NA 26.94 hours 1compartment NA NA Human Human -DTXSID1046211 Css NA 20.58 mg/L 3compartmentss NA 50% Human Human -DTXSID1046211 Css NA 146.7 mg/L 3compartmentss NA 95% Human Human -DTXSID1046211 Css NA 12.28 mg/L PBTK NA 50% Human Human -DTXSID1046211 Css NA 85.61 mg/L PBTK NA 95% Human Human -DTXSID1046211 Clint NA 1.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046211 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046211 Vd NA 0.2191 L/kg 1compartment NA NA Rat Human -DTXSID1046211 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1046211 TK.Half.Life NA 13.56 hours 1compartment NA NA Rat Human -DTXSID1046211 Css NA 9.085 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046211 Css NA 54.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046211 Css NA 5.028 mg/L PBTK NA 50% Rat Human -DTXSID1046211 Css NA 29.33 mg/L PBTK NA 95% Rat Human -DTXSID1046213 Clint NA 1961 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046213 Fup NA 0.0281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046213 Vd NA 2.42 L/kg 1compartment NA NA Human Human -DTXSID1046213 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046213 TK.Half.Life NA 2.294 hours 1compartment NA NA Human Human -DTXSID1046213 Css NA 0.01563 mg/L 3compartmentss NA 50% Human Human -DTXSID1046213 Css NA 0.1159 mg/L 3compartmentss NA 95% Human Human -DTXSID1046213 Css NA 0.0103 mg/L PBTK NA 50% Human Human -DTXSID1046213 Css NA 0.07326 mg/L PBTK NA 95% Human Human -DTXSID1046213 Clint NA 1961 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046213 Fup NA 0.0281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046213 Vd NA 1.808 L/kg 1compartment NA NA Rat Human -DTXSID1046213 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046213 TK.Half.Life NA 0.7342 hours 1compartment NA NA Rat Human -DTXSID1046213 Css NA 0.008712 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046213 Css NA 0.05628 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046213 Css NA 0.005476 mg/L PBTK NA 50% Rat Human -DTXSID1046213 Css NA 0.03395 mg/L PBTK NA 95% Rat Human -DTXSID1046215 Clint NA 1.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046215 Fup NA 0.2415 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046215 Vd NA 0.39 L/kg 1compartment NA NA Human Human +DTXSID1046188 TK.Half.Life NA 1.296 hours 1compartment NA NA Rat Human +DTXSID1046188 Css NA 0.05544 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046188 Css NA 0.2459 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046188 Css NA 0.03632 mg/L PBTK NA 50% Rat Human +DTXSID1046188 Css NA 0.1495 mg/L PBTK NA 95% Rat Human +DTXSID1046211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046211 Fup 0.0325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046211 Vd NA 1.87 L/kg 1compartment NA NA Human Human +DTXSID1046211 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1046211 TK.Half.Life NA 13.19 hours 1compartment NA NA Human Human +DTXSID1046211 Css NA 1.014 mg/L 3compartmentss NA 50% Human Human +DTXSID1046211 Css NA 8.024 mg/L 3compartmentss NA 95% Human Human +DTXSID1046211 Css NA 0.654 mg/L PBTK NA 50% Human Human +DTXSID1046211 Css NA 4.951 mg/L PBTK NA 95% Human Human +DTXSID1046211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046211 Fup 0.0325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046211 Vd NA 1.396 L/kg 1compartment NA NA Rat Human +DTXSID1046211 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1046211 TK.Half.Life NA 4.495 hours 1compartment NA NA Rat Human +DTXSID1046211 Css NA 0.1294 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046211 Css NA 0.8369 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046211 Css NA 0.08142 mg/L PBTK NA 50% Rat Human +DTXSID1046211 Css NA 0.5072 mg/L PBTK NA 95% Rat Human +DTXSID1046213 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046213 Fup 0.0218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046213 Vd NA 2.087 L/kg 1compartment NA NA Human Human +DTXSID1046213 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1046213 TK.Half.Life NA 20.65 hours 1compartment NA NA Human Human +DTXSID1046213 Css NA 1.441 mg/L 3compartmentss NA 50% Human Human +DTXSID1046213 Css NA 11.92 mg/L 3compartmentss NA 95% Human Human +DTXSID1046213 Css NA 0.9324 mg/L PBTK NA 50% Human Human +DTXSID1046213 Css NA 7.338 mg/L PBTK NA 95% Human Human +DTXSID1046213 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046213 Fup 0.0218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046213 Vd NA 1.554 L/kg 1compartment NA NA Rat Human +DTXSID1046213 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1046213 TK.Half.Life NA 6.406 hours 1compartment NA NA Rat Human +DTXSID1046213 Css NA 0.1861 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046213 Css NA 1.237 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046213 Css NA 0.1174 mg/L PBTK NA 50% Rat Human +DTXSID1046213 Css NA 0.7454 mg/L PBTK NA 95% Rat Human +DTXSID1046215 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046215 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046215 Vd NA 0.4429 L/kg 1compartment NA NA Human Human DTXSID1046215 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046215 TK.Half.Life NA 3.336 hours 1compartment NA NA Human Human -DTXSID1046215 Css NA 1.028 mg/L 3compartmentss NA 50% Human Human -DTXSID1046215 Css NA 4.532 mg/L 3compartmentss NA 95% Human Human -DTXSID1046215 Css NA 0.6818 mg/L PBTK NA 50% Human Human -DTXSID1046215 Css NA 2.792 mg/L PBTK NA 95% Human Human -DTXSID1046215 Clint NA 1.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046215 Fup NA 0.2415 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046215 Vd NA 0.3875 L/kg 1compartment NA NA Rat Human +DTXSID1046215 TK.Half.Life NA 9.178 hours 1compartment NA NA Human Human +DTXSID1046215 Css NA 1.318 mg/L 3compartmentss NA 50% Human Human +DTXSID1046215 Css NA 5.493 mg/L 3compartmentss NA 95% Human Human +DTXSID1046215 Css NA 0.9094 mg/L PBTK NA 50% Human Human +DTXSID1046215 Css NA 3.424 mg/L PBTK NA 95% Human Human +DTXSID1046215 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046215 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046215 Vd NA 0.4413 L/kg 1compartment NA NA Rat Human DTXSID1046215 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046215 TK.Half.Life NA 1.714 hours 1compartment NA NA Rat Human -DTXSID1046215 Css NA 0.44 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046215 Css NA 1.514 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046215 Css NA 0.2764 mg/L PBTK NA 50% Rat Human -DTXSID1046215 Css NA 0.8625 mg/L PBTK NA 95% Rat Human -DTXSID1046217 Clint NA 4.574 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046217 Fup NA 0.0315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046217 Vd NA 1.919 L/kg 1compartment NA NA Human Human -DTXSID1046217 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1046217 TK.Half.Life NA 24.84 hours 1compartment NA NA Human Human -DTXSID1046217 Css NA 1.899 mg/L 3compartmentss NA 50% Human Human -DTXSID1046217 Css NA 17.96 mg/L 3compartmentss NA 95% Human Human -DTXSID1046217 Css NA 1.354 mg/L PBTK NA 50% Human Human -DTXSID1046217 Css NA 11.17 mg/L PBTK NA 95% Human Human -DTXSID1046217 Clint NA 4.574 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046217 Fup NA 0.0315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046217 Vd NA 1.714 L/kg 1compartment NA NA Rat Human -DTXSID1046217 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1046217 TK.Half.Life NA 12.63 hours 1compartment NA NA Rat Human -DTXSID1046217 Css NA 1.041 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046217 Css NA 7.193 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046217 Css NA 0.7001 mg/L PBTK NA 50% Rat Human -DTXSID1046217 Css NA 4.234 mg/L PBTK NA 95% Rat Human +DTXSID1046215 TK.Half.Life NA 3.111 hours 1compartment NA NA Rat Human +DTXSID1046215 Css NA 0.007177 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046215 Css NA 0.03004 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046215 Css NA 0.004695 mg/L PBTK NA 50% Rat Human +DTXSID1046215 Css NA 0.01811 mg/L PBTK NA 95% Rat Human +DTXSID1046217 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046217 Fup 0.0296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046217 Vd NA 1.844 L/kg 1compartment NA NA Human Human +DTXSID1046217 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046217 TK.Half.Life NA 6.652 hours 1compartment NA NA Human Human +DTXSID1046217 Css NA 0.4424 mg/L 3compartmentss NA 50% Human Human +DTXSID1046217 Css NA 4.839 mg/L 3compartmentss NA 95% Human Human +DTXSID1046217 Css NA 0.3122 mg/L PBTK NA 50% Human Human +DTXSID1046217 Css NA 3.044 mg/L PBTK NA 95% Human Human +DTXSID1046217 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046217 Fup 0.0296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046217 Vd NA 1.646 L/kg 1compartment NA NA Rat Human +DTXSID1046217 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1046217 TK.Half.Life NA 3.388 hours 1compartment NA NA Rat Human +DTXSID1046217 Css NA 0.05806 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046217 Css NA 0.4765 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046217 Css NA 0.03972 mg/L PBTK NA 50% Rat Human +DTXSID1046217 Css NA 0.2943 mg/L PBTK NA 95% Rat Human DTXSID1046261 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046261 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046261 Vd NA 0.469 L/kg 1compartment NA NA Human Human +DTXSID1046261 Vd NA 0.4665 L/kg 1compartment NA NA Human Human DTXSID1046261 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046261 TK.Half.Life NA 3.035 hours 1compartment NA NA Human Human -DTXSID1046261 Css NA 0.9338 mg/L 3compartmentss NA 50% Human Human -DTXSID1046261 Css NA 5.731 mg/L 3compartmentss NA 95% Human Human -DTXSID1046261 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID1046261 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID1046261 TK.Half.Life NA 3.019 hours 1compartment NA NA Human Human +DTXSID1046261 Css NA 0.7894 mg/L 3compartmentss NA 50% Human Human +DTXSID1046261 Css NA 5.229 mg/L 3compartmentss NA 95% Human Human +DTXSID1046261 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID1046261 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID1046261 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046261 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046261 Vd NA 0.5023 L/kg 1compartment NA NA Rat Human +DTXSID1046261 Vd NA 0.5002 L/kg 1compartment NA NA Rat Human DTXSID1046261 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046261 TK.Half.Life NA 1.107 hours 1compartment NA NA Rat Human -DTXSID1046261 Css NA 0.2374 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046261 Css NA 1.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046261 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID1046261 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID1046263 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046263 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046263 Vd NA 1954 L/kg 1compartment NA NA Human Human -DTXSID1046263 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID1046263 TK.Half.Life NA 69310000 hours 1compartment NA NA Human Human -DTXSID1046263 Css NA 9.015 mg/L 3compartmentss NA 50% Human Human -DTXSID1046263 Css NA 30.65 mg/L 3compartmentss NA 95% Human Human -DTXSID1046263 Css NA 2930 mg/L PBTK NA 50% Human Human -DTXSID1046263 Css NA 6724 mg/L PBTK NA 95% Human Human -DTXSID1046263 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046263 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046263 Vd NA 1807 L/kg 1compartment NA NA Rat Human -DTXSID1046263 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID1046263 TK.Half.Life NA 5874000 hours 1compartment NA NA Rat Human -DTXSID1046263 Css NA 2.133 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046263 Css NA 6.317 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046263 Css NA 769.7 mg/L PBTK NA 50% Rat Human -DTXSID1046263 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID1046261 TK.Half.Life NA 1.103 hours 1compartment NA NA Rat Human +DTXSID1046261 Css NA 0.0146 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046261 Css NA 0.1054 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046261 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID1046261 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID1046265 Clint NA 0.1361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046265 Fup NA 0.0129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046265 Vd NA 0.2453 L/kg 1compartment NA NA Human Human -DTXSID1046265 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID1046265 TK.Half.Life NA 100.3 hours 1compartment NA NA Human Human -DTXSID1046265 Css NA 68.53 mg/L 3compartmentss NA 50% Human Human -DTXSID1046265 Css NA 434.5 mg/L 3compartmentss NA 95% Human Human -DTXSID1046265 Css NA 40.7 mg/L PBTK NA 50% Human Human -DTXSID1046265 Css NA 255.3 mg/L PBTK NA 95% Human Human +DTXSID1046265 Vd NA 0.235 L/kg 1compartment NA NA Human Human +DTXSID1046265 Days.Css NA 20 Days PBTK NA NA Human Human +DTXSID1046265 TK.Half.Life NA 96.1 hours 1compartment NA NA Human Human +DTXSID1046265 Css NA 66.54 mg/L 3compartmentss NA 50% Human Human +DTXSID1046265 Css NA 420.2 mg/L 3compartmentss NA 95% Human Human +DTXSID1046265 Css NA 39.52 mg/L PBTK NA 50% Human Human +DTXSID1046265 Css NA 246.6 mg/L PBTK NA 95% Human Human DTXSID1046265 Clint NA 0.1361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046265 Fup NA 0.0129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046265 Vd NA 0.2357 L/kg 1compartment NA NA Rat Human -DTXSID1046265 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID1046265 TK.Half.Life NA 36.27 hours 1compartment NA NA Rat Human -DTXSID1046265 Css NA 21.63 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046265 Css NA 125.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046265 Css NA 12.01 mg/L PBTK NA 50% Rat Human -DTXSID1046265 Css NA 68.18 mg/L PBTK NA 95% Rat Human -DTXSID1046267 Clint NA 30.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046267 Fup NA 0.0619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046267 Vd NA 1.811 L/kg 1compartment NA NA Human Human +DTXSID1046265 Vd NA 0.2267 L/kg 1compartment NA NA Rat Human +DTXSID1046265 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID1046265 TK.Half.Life NA 34.9 hours 1compartment NA NA Rat Human +DTXSID1046265 Css NA 4.916 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046265 Css NA 27.57 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046265 Css NA 2.819 mg/L PBTK NA 50% Rat Human +DTXSID1046265 Css NA 15.47 mg/L PBTK NA 95% Rat Human +DTXSID1046267 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046267 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046267 Vd NA 1.303 L/kg 1compartment NA NA Human Human DTXSID1046267 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046267 TK.Half.Life NA 6.048 hours 1compartment NA NA Human Human -DTXSID1046267 Css NA 0.4076 mg/L 3compartmentss NA 50% Human Human -DTXSID1046267 Css NA 2.973 mg/L 3compartmentss NA 95% Human Human -DTXSID1046267 Css NA 0.2679 mg/L PBTK NA 50% Human Human -DTXSID1046267 Css NA 1.86 mg/L PBTK NA 95% Human Human -DTXSID1046267 Clint NA 30.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046267 Fup NA 0.0619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046267 Vd NA 1.362 L/kg 1compartment NA NA Rat Human +DTXSID1046267 TK.Half.Life NA 8.969 hours 1compartment NA NA Human Human +DTXSID1046267 Css NA 0.9406 mg/L 3compartmentss NA 50% Human Human +DTXSID1046267 Css NA 6.102 mg/L 3compartmentss NA 95% Human Human +DTXSID1046267 Css NA 0.6209 mg/L PBTK NA 50% Human Human +DTXSID1046267 Css NA 3.79 mg/L PBTK NA 95% Human Human +DTXSID1046267 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046267 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046267 Vd NA 1.007 L/kg 1compartment NA NA Rat Human DTXSID1046267 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046267 TK.Half.Life NA 2.122 hours 1compartment NA NA Rat Human -DTXSID1046267 Css NA 0.231 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046267 Css NA 1.341 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046267 Css NA 0.1424 mg/L PBTK NA 50% Rat Human -DTXSID1046267 Css NA 0.8045 mg/L PBTK NA 95% Rat Human -DTXSID1046269 Clint NA 32.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046269 Fup NA 0.3397 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046269 Vd NA 3.551 L/kg 1compartment NA NA Human Human +DTXSID1046267 TK.Half.Life NA 3.652 hours 1compartment NA NA Rat Human +DTXSID1046267 Css NA 0.1136 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046267 Css NA 0.5654 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046267 Css NA 0.07317 mg/L PBTK NA 50% Rat Human +DTXSID1046267 Css NA 0.3387 mg/L PBTK NA 95% Rat Human +DTXSID1046269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046269 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046269 Vd NA 3.157 L/kg 1compartment NA NA Human Human DTXSID1046269 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046269 TK.Half.Life NA 3.819 hours 1compartment NA NA Human Human -DTXSID1046269 Css NA 0.0495 mg/L 3compartmentss NA 50% Human Human -DTXSID1046269 Css NA 0.3495 mg/L 3compartmentss NA 95% Human Human -DTXSID1046269 Css NA 0.04804 mg/L PBTK NA 50% Human Human -DTXSID1046269 Css NA 0.3005 mg/L PBTK NA 95% Human Human -DTXSID1046269 Clint NA 32.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046269 Fup NA 0.3397 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046269 Vd NA 3.182 L/kg 1compartment NA NA Rat Human +DTXSID1046269 TK.Half.Life NA 4.671 hours 1compartment NA NA Human Human +DTXSID1046269 Css NA 0.0851 mg/L 3compartmentss NA 50% Human Human +DTXSID1046269 Css NA 0.595 mg/L 3compartmentss NA 95% Human Human +DTXSID1046269 Css NA 0.07866 mg/L PBTK NA 50% Human Human +DTXSID1046269 Css NA 0.4951 mg/L PBTK NA 95% Human Human +DTXSID1046269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046269 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046269 Vd NA 2.829 L/kg 1compartment NA NA Rat Human DTXSID1046269 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046269 TK.Half.Life NA 1.451 hours 1compartment NA NA Rat Human -DTXSID1046269 Css NA 0.02604 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046269 Css NA 0.1519 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046269 Css NA 0.02509 mg/L PBTK NA 50% Rat Human -DTXSID1046269 Css NA 0.1272 mg/L PBTK NA 95% Rat Human -DTXSID1046342 Clint NA 12.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1046269 TK.Half.Life NA 1.889 hours 1compartment NA NA Rat Human +DTXSID1046269 Css NA 0.01042 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046269 Css NA 0.05651 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046269 Css NA 0.009795 mg/L PBTK NA 50% Rat Human +DTXSID1046269 Css NA 0.04848 mg/L PBTK NA 95% Rat Human +DTXSID1046342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1046342 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1046342 Vd NA 1.545 L/kg 1compartment NA NA Human Human -DTXSID1046342 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID1046342 TK.Half.Life NA 39.54 hours 1compartment NA NA Human Human -DTXSID1046342 Css NA 4.351 mg/L 3compartmentss NA 50% Human Human -DTXSID1046342 Css NA 36.94 mg/L 3compartmentss NA 95% Human Human -DTXSID1046342 Css NA 2.7 mg/L PBTK NA 50% Human Human -DTXSID1046342 Css NA 22.4 mg/L PBTK NA 95% Human Human -DTXSID1046342 Clint NA 12.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1046342 Vd NA 1.502 L/kg 1compartment NA NA Human Human +DTXSID1046342 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1046342 TK.Half.Life NA 22.5 hours 1compartment NA NA Human Human +DTXSID1046342 Css NA 2.415 mg/L 3compartmentss NA 50% Human Human +DTXSID1046342 Css NA 22.02 mg/L 3compartmentss NA 95% Human Human +DTXSID1046342 Css NA 1.507 mg/L PBTK NA 50% Human Human +DTXSID1046342 Css NA 13.2 mg/L PBTK NA 95% Human Human +DTXSID1046342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1046342 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1046342 Vd NA 1.14 L/kg 1compartment NA NA Rat Human -DTXSID1046342 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1046342 TK.Half.Life NA 14.9 hours 1compartment NA NA Rat Human -DTXSID1046342 Css NA 2.436 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046342 Css NA 16.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046342 Css NA 1.412 mg/L PBTK NA 50% Rat Human -DTXSID1046342 Css NA 9.236 mg/L PBTK NA 95% Rat Human +DTXSID1046342 Vd NA 1.108 L/kg 1compartment NA NA Rat Human +DTXSID1046342 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1046342 TK.Half.Life NA 8.662 hours 1compartment NA NA Rat Human +DTXSID1046342 Css NA 0.3156 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046342 Css NA 2.441 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046342 Css NA 0.1906 mg/L PBTK NA 50% Rat Human +DTXSID1046342 Css NA 1.409 mg/L PBTK NA 95% Rat Human DTXSID1046344 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046344 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1046344 Vd NA 0.2067 L/kg 1compartment NA NA Human Human -DTXSID1046344 Days.Css NA 113 Days PBTK NA NA Human Human -DTXSID1046344 TK.Half.Life NA 446 hours 1compartment NA NA Human Human -DTXSID1046344 Css NA 376.2 mg/L 3compartmentss NA 50% Human Human -DTXSID1046344 Css NA 1823 mg/L 3compartmentss NA 95% Human Human -DTXSID1046344 Css NA 220 mg/L PBTK NA 50% Human Human -DTXSID1046344 Css NA 1041 mg/L PBTK NA 95% Human Human +DTXSID1046344 Vd NA 0.1631 L/kg 1compartment NA NA Human Human +DTXSID1046344 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046344 TK.Half.Life NA 351.7 hours 1compartment NA NA Human Human +DTXSID1046344 Css NA 322 mg/L 3compartmentss NA 50% Human Human +DTXSID1046344 Css NA 1512 mg/L 3compartmentss NA 95% Human Human +DTXSID1046344 Css NA 186.6 mg/L PBTK NA 50% Human Human +DTXSID1046344 Css NA 881.1 mg/L PBTK NA 95% Human Human DTXSID1046344 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046344 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1046344 Vd NA 0.1969 L/kg 1compartment NA NA Rat Human -DTXSID1046344 Days.Css NA 33 Days PBTK NA NA Rat Human -DTXSID1046344 TK.Half.Life NA 144.8 hours 1compartment NA NA Rat Human -DTXSID1046344 Css NA 109.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046344 Css NA 427.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046344 Css NA 59.57 mg/L PBTK NA 50% Rat Human -DTXSID1046344 Css NA 231.5 mg/L PBTK NA 95% Rat Human -DTXSID1046346 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046346 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046346 Vd NA 0.7322 L/kg 1compartment NA NA Human Human +DTXSID1046344 Vd NA 0.1616 L/kg 1compartment NA NA Rat Human +DTXSID1046344 Days.Css NA 26 Days PBTK NA NA Rat Human +DTXSID1046344 TK.Half.Life NA 118.8 hours 1compartment NA NA Rat Human +DTXSID1046344 Css NA 6.067 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046344 Css NA 40.26 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046344 Css NA 3.317 mg/L PBTK NA 50% Rat Human +DTXSID1046344 Css NA 22.29 mg/L PBTK NA 95% Rat Human +DTXSID1046346 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046346 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046346 Vd NA 0.6425 L/kg 1compartment NA NA Human Human DTXSID1046346 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046346 TK.Half.Life NA 4.738 hours 1compartment NA NA Human Human -DTXSID1046346 Css NA 0.8392 mg/L 3compartmentss NA 50% Human Human -DTXSID1046346 Css NA 5.532 mg/L 3compartmentss NA 95% Human Human -DTXSID1046346 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID1046346 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID1046346 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046346 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046346 Vd NA 0.7766 L/kg 1compartment NA NA Rat Human +DTXSID1046346 TK.Half.Life NA 5.177 hours 1compartment NA NA Human Human +DTXSID1046346 Css NA 0.8666 mg/L 3compartmentss NA 50% Human Human +DTXSID1046346 Css NA 4.968 mg/L 3compartmentss NA 95% Human Human +DTXSID1046346 Css NA 0.6936 mg/L PBTK NA 50% Human Human +DTXSID1046346 Css NA 3.236 mg/L PBTK NA 95% Human Human +DTXSID1046346 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046346 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046346 Vd NA 0.6809 L/kg 1compartment NA NA Rat Human DTXSID1046346 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046346 TK.Half.Life NA 1.712 hours 1compartment NA NA Rat Human -DTXSID1046346 Css NA 0.2108 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046346 Css NA 1.312 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046346 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID1046346 Css NA 0.7874 mg/L PBTK NA 95% Rat Human +DTXSID1046346 TK.Half.Life NA 1.87 hours 1compartment NA NA Rat Human +DTXSID1046346 Css NA 0.01614 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046346 Css NA 0.1218 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046346 Css NA 0.01229 mg/L PBTK NA 50% Rat Human +DTXSID1046346 Css NA 0.07723 mg/L PBTK NA 95% Rat Human DTXSID1046348 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046348 Fup NA 0.9131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046348 Vd NA 0.6583 L/kg 1compartment NA NA Human Human +DTXSID1046348 Vd NA 0.6663 L/kg 1compartment NA NA Human Human DTXSID1046348 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046348 TK.Half.Life NA 4.665 hours 1compartment NA NA Human Human -DTXSID1046348 Css NA 0.9464 mg/L 3compartmentss NA 50% Human Human -DTXSID1046348 Css NA 5.067 mg/L 3compartmentss NA 95% Human Human -DTXSID1046348 Css NA 0.763 mg/L PBTK NA 50% Human Human -DTXSID1046348 Css NA 3.342 mg/L PBTK NA 95% Human Human +DTXSID1046348 TK.Half.Life NA 4.722 hours 1compartment NA NA Human Human +DTXSID1046348 Css NA 0.8003 mg/L 3compartmentss NA 50% Human Human +DTXSID1046348 Css NA 4.351 mg/L 3compartmentss NA 95% Human Human +DTXSID1046348 Css NA 0.6468 mg/L PBTK NA 50% Human Human +DTXSID1046348 Css NA 2.846 mg/L PBTK NA 95% Human Human DTXSID1046348 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046348 Fup NA 0.9131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046348 Vd NA 0.7045 L/kg 1compartment NA NA Rat Human +DTXSID1046348 Vd NA 0.7111 L/kg 1compartment NA NA Rat Human DTXSID1046348 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046348 TK.Half.Life NA 1.701 hours 1compartment NA NA Rat Human -DTXSID1046348 Css NA 0.2428 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046348 Css NA 1.346 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046348 Css NA 0.1896 mg/L PBTK NA 50% Rat Human -DTXSID1046348 Css NA 0.8032 mg/L PBTK NA 95% Rat Human -DTXSID1046390 Clint NA 11.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046390 Fup NA 0.1458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046390 Vd NA 0.275 L/kg 1compartment NA NA Human Human +DTXSID1046348 TK.Half.Life NA 1.717 hours 1compartment NA NA Rat Human +DTXSID1046348 Css NA 0.01503 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046348 Css NA 0.1045 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046348 Css NA 0.01165 mg/L PBTK NA 50% Rat Human +DTXSID1046348 Css NA 0.06845 mg/L PBTK NA 95% Rat Human +DTXSID1046390 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046390 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046390 Vd NA 0.3425 L/kg 1compartment NA NA Human Human DTXSID1046390 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046390 TK.Half.Life NA 0.8559 hours 1compartment NA NA Human Human -DTXSID1046390 Css NA 0.3722 mg/L 3compartmentss NA 50% Human Human -DTXSID1046390 Css NA 2.885 mg/L 3compartmentss NA 95% Human Human -DTXSID1046390 Css NA 0.2314 mg/L PBTK NA 50% Human Human -DTXSID1046390 Css NA 1.736 mg/L PBTK NA 95% Human Human -DTXSID1046390 Clint NA 11.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046390 Fup NA 0.1458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046390 Vd NA 0.2784 L/kg 1compartment NA NA Rat Human +DTXSID1046390 TK.Half.Life NA 1.016 hours 1compartment NA NA Human Human +DTXSID1046390 Css NA 0.2881 mg/L 3compartmentss NA 50% Human Human +DTXSID1046390 Css NA 1.715 mg/L 3compartmentss NA 95% Human Human +DTXSID1046390 Css NA 0.1888 mg/L PBTK NA 50% Human Human +DTXSID1046390 Css NA 1.062 mg/L PBTK NA 95% Human Human +DTXSID1046390 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046390 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046390 Vd NA 0.349 L/kg 1compartment NA NA Rat Human DTXSID1046390 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046390 TK.Half.Life NA 0.515 hours 1compartment NA NA Rat Human -DTXSID1046390 Css NA 0.2016 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046390 Css NA 1.128 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046390 Css NA 0.1173 mg/L PBTK NA 50% Rat Human -DTXSID1046390 Css NA 0.6335 mg/L PBTK NA 95% Rat Human -DTXSID1046392 Clint NA 0.5792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046392 Fup NA 0.863 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046392 Vd NA 1.151 L/kg 1compartment NA NA Human Human +DTXSID1046390 TK.Half.Life NA 0.597 hours 1compartment NA NA Rat Human +DTXSID1046390 Css NA 0.03462 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046390 Css NA 0.1459 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046390 Css NA 0.02227 mg/L PBTK NA 50% Rat Human +DTXSID1046390 Css NA 0.08787 mg/L PBTK NA 95% Rat Human +DTXSID1046392 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046392 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046392 Vd NA 0.8339 L/kg 1compartment NA NA Human Human DTXSID1046392 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046392 TK.Half.Life NA 4.715 hours 1compartment NA NA Human Human -DTXSID1046392 Css NA 0.4502 mg/L 3compartmentss NA 50% Human Human -DTXSID1046392 Css NA 2.877 mg/L 3compartmentss NA 95% Human Human -DTXSID1046392 Css NA 0.4024 mg/L PBTK NA 50% Human Human -DTXSID1046392 Css NA 1.949 mg/L PBTK NA 95% Human Human -DTXSID1046392 Clint NA 0.5792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046392 Fup NA 0.863 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046392 Vd NA 1.099 L/kg 1compartment NA NA Rat Human +DTXSID1046392 TK.Half.Life NA 0.8332 hours 1compartment NA NA Human Human +DTXSID1046392 Css NA 0.03942 mg/L 3compartmentss NA 50% Human Human +DTXSID1046392 Css NA 0.3407 mg/L 3compartmentss NA 95% Human Human +DTXSID1046392 Css NA 0.0308 mg/L PBTK NA 50% Human Human +DTXSID1046392 Css NA 0.2394 mg/L PBTK NA 95% Human Human +DTXSID1046392 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046392 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046392 Vd NA 0.7887 L/kg 1compartment NA NA Rat Human DTXSID1046392 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046392 TK.Half.Life NA 1.955 hours 1compartment NA NA Rat Human -DTXSID1046392 Css NA 0.1533 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046392 Css NA 0.9418 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046392 Css NA 0.1354 mg/L PBTK NA 50% Rat Human -DTXSID1046392 Css NA 0.5882 mg/L PBTK NA 95% Rat Human -DTXSID1046394 Clint NA 3.565 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046394 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046394 Vd NA 0.2378 L/kg 1compartment NA NA Human Human +DTXSID1046392 TK.Half.Life NA 0.3972 hours 1compartment NA NA Rat Human +DTXSID1046392 Css NA 0.004729 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046392 Css NA 0.03498 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046392 Css NA 0.003747 mg/L PBTK NA 50% Rat Human +DTXSID1046392 Css NA 0.02319 mg/L PBTK NA 95% Rat Human +DTXSID1046394 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046394 Fup 0.0742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046394 Vd NA 0.3258 L/kg 1compartment NA NA Human Human DTXSID1046394 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046394 TK.Half.Life NA 7.709 hours 1compartment NA NA Human Human -DTXSID1046394 Css NA 5.939 mg/L 3compartmentss NA 50% Human Human -DTXSID1046394 Css NA 43.21 mg/L 3compartmentss NA 95% Human Human -DTXSID1046394 Css NA 3.535 mg/L PBTK NA 50% Human Human -DTXSID1046394 Css NA 25.09 mg/L PBTK NA 95% Human Human -DTXSID1046394 Clint NA 3.565 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046394 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046394 Vd NA 0.2229 L/kg 1compartment NA NA Rat Human +DTXSID1046394 TK.Half.Life NA 1.043 hours 1compartment NA NA Human Human +DTXSID1046394 Css NA 0.3982 mg/L 3compartmentss NA 50% Human Human +DTXSID1046394 Css NA 3.087 mg/L 3compartmentss NA 95% Human Human +DTXSID1046394 Css NA 0.2454 mg/L PBTK NA 50% Human Human +DTXSID1046394 Css NA 1.84 mg/L PBTK NA 95% Human Human +DTXSID1046394 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046394 Fup 0.0742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046394 Vd NA 0.302 L/kg 1compartment NA NA Rat Human DTXSID1046394 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046394 TK.Half.Life NA 4.354 hours 1compartment NA NA Rat Human -DTXSID1046394 Css NA 2.946 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046394 Css NA 18.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046394 Css NA 1.633 mg/L PBTK NA 50% Rat Human -DTXSID1046394 Css NA 9.818 mg/L PBTK NA 95% Rat Human -DTXSID1046396 Clint NA 384.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046396 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046396 Vd NA 2298 L/kg 1compartment NA NA Human Human -DTXSID1046396 Days.Css NA 1022 Days PBTK NA NA Human Human -DTXSID1046396 TK.Half.Life NA 3907 hours 1compartment NA NA Human Human -DTXSID1046396 Css NA 0.0003745 mg/L 3compartmentss NA 50% Human Human -DTXSID1046396 Css NA 0.002407 mg/L 3compartmentss NA 95% Human Human -DTXSID1046396 Css NA 0.1441 mg/L PBTK NA 50% Human Human -DTXSID1046396 Css NA 0.8304 mg/L PBTK NA 95% Human Human -DTXSID1046396 Clint NA 384.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046396 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046396 Vd NA 2131 L/kg 1compartment NA NA Rat Human -DTXSID1046396 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID1046396 TK.Half.Life NA 685.6 hours 1compartment NA NA Rat Human -DTXSID1046396 Css NA 0.0001891 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046396 Css NA 0.0008258 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046396 Css NA 0.07862 mg/L PBTK NA 50% Rat Human -DTXSID1046396 Css NA 0.3346 mg/L PBTK NA 95% Rat Human -DTXSID1046398 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046398 Fup NA 0.4239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046398 Vd NA 0.6927 L/kg 1compartment NA NA Human Human +DTXSID1046394 TK.Half.Life NA 0.5879 hours 1compartment NA NA Rat Human +DTXSID1046394 Css NA 0.05199 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046394 Css NA 0.3294 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046394 Css NA 0.03093 mg/L PBTK NA 50% Rat Human +DTXSID1046394 Css NA 0.1908 mg/L PBTK NA 95% Rat Human +DTXSID1046398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046398 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046398 Vd NA 0.7163 L/kg 1compartment NA NA Human Human DTXSID1046398 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046398 TK.Half.Life NA 1.418 hours 1compartment NA NA Human Human -DTXSID1046398 Css NA 0.1705 mg/L 3compartmentss NA 50% Human Human -DTXSID1046398 Css NA 1.195 mg/L 3compartmentss NA 95% Human Human -DTXSID1046398 Css NA 0.1294 mg/L PBTK NA 50% Human Human -DTXSID1046398 Css NA 0.7943 mg/L PBTK NA 95% Human Human -DTXSID1046398 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046398 Fup NA 0.4239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046398 Vd NA 0.6695 L/kg 1compartment NA NA Rat Human +DTXSID1046398 TK.Half.Life NA 0.7362 hours 1compartment NA NA Human Human +DTXSID1046398 Css NA 0.04055 mg/L 3compartmentss NA 50% Human Human +DTXSID1046398 Css NA 0.3687 mg/L 3compartmentss NA 95% Human Human +DTXSID1046398 Css NA 0.03116 mg/L PBTK NA 50% Human Human +DTXSID1046398 Css NA 0.2505 mg/L PBTK NA 95% Human Human +DTXSID1046398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046398 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046398 Vd NA 0.697 L/kg 1compartment NA NA Rat Human DTXSID1046398 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046398 TK.Half.Life NA 0.7599 hours 1compartment NA NA Rat Human -DTXSID1046398 Css NA 0.08532 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046398 Css NA 0.4386 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046398 Css NA 0.0621 mg/L PBTK NA 50% Rat Human -DTXSID1046398 Css NA 0.2739 mg/L PBTK NA 95% Rat Human +DTXSID1046398 TK.Half.Life NA 0.3633 hours 1compartment NA NA Rat Human +DTXSID1046398 Css NA 0.004995 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046398 Css NA 0.03597 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046398 Css NA 0.003869 mg/L PBTK NA 50% Rat Human +DTXSID1046398 Css NA 0.02358 mg/L PBTK NA 95% Rat Human DTXSID1046421 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046421 Fup NA 0.4089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046421 Vd NA 0.3724 L/kg 1compartment NA NA Human Human +DTXSID1046421 Vd NA 0.3681 L/kg 1compartment NA NA Human Human DTXSID1046421 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046421 TK.Half.Life NA 5.894 hours 1compartment NA NA Human Human -DTXSID1046421 Css NA 1.912 mg/L 3compartmentss NA 50% Human Human -DTXSID1046421 Css NA 7.963 mg/L 3compartmentss NA 95% Human Human -DTXSID1046421 Css NA 1.32 mg/L PBTK NA 50% Human Human -DTXSID1046421 Css NA 4.903 mg/L PBTK NA 95% Human Human +DTXSID1046421 TK.Half.Life NA 5.825 hours 1compartment NA NA Human Human +DTXSID1046421 Css NA 1.838 mg/L 3compartmentss NA 50% Human Human +DTXSID1046421 Css NA 7.801 mg/L 3compartmentss NA 95% Human Human +DTXSID1046421 Css NA 1.278 mg/L PBTK NA 50% Human Human +DTXSID1046421 Css NA 4.899 mg/L PBTK NA 95% Human Human DTXSID1046421 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046421 Fup NA 0.4089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046421 Vd NA 0.3829 L/kg 1compartment NA NA Rat Human +DTXSID1046421 Vd NA 0.3792 L/kg 1compartment NA NA Rat Human DTXSID1046421 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046421 TK.Half.Life NA 2.065 hours 1compartment NA NA Rat Human -DTXSID1046421 Css NA 0.5228 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046421 Css NA 1.917 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046421 Css NA 0.3438 mg/L PBTK NA 50% Rat Human -DTXSID1046421 Css NA 1.105 mg/L PBTK NA 95% Rat Human -DTXSID1046423 Clint NA 17.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046423 Fup NA 0.0507 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046423 Vd NA 2.204 L/kg 1compartment NA NA Human Human -DTXSID1046423 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1046423 TK.Half.Life NA 15.67 hours 1compartment NA NA Human Human -DTXSID1046423 Css NA 0.9614 mg/L 3compartmentss NA 50% Human Human -DTXSID1046423 Css NA 6.587 mg/L 3compartmentss NA 95% Human Human -DTXSID1046423 Css NA 0.6372 mg/L PBTK NA 50% Human Human -DTXSID1046423 Css NA 4.127 mg/L PBTK NA 95% Human Human -DTXSID1046423 Clint NA 17.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046423 Fup NA 0.0507 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046423 Vd NA 1.651 L/kg 1compartment NA NA Rat Human +DTXSID1046421 TK.Half.Life NA 2.045 hours 1compartment NA NA Rat Human +DTXSID1046421 Css NA 0.1184 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046421 Css NA 0.425 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046421 Css NA 0.08022 mg/L PBTK NA 50% Rat Human +DTXSID1046421 Css NA 0.2537 mg/L PBTK NA 95% Rat Human +DTXSID1046423 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046423 Fup 0.0816 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046423 Vd NA 2.387 L/kg 1compartment NA NA Human Human +DTXSID1046423 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046423 TK.Half.Life NA 11.17 hours 1compartment NA NA Human Human +DTXSID1046423 Css NA 0.5407 mg/L 3compartmentss NA 50% Human Human +DTXSID1046423 Css NA 3.7 mg/L 3compartmentss NA 95% Human Human +DTXSID1046423 Css NA 0.3682 mg/L PBTK NA 50% Human Human +DTXSID1046423 Css NA 2.458 mg/L PBTK NA 95% Human Human +DTXSID1046423 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046423 Fup 0.0816 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046423 Vd NA 1.798 L/kg 1compartment NA NA Rat Human DTXSID1046423 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046423 TK.Half.Life NA 4.643 hours 1compartment NA NA Rat Human -DTXSID1046423 Css NA 0.5394 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046423 Css NA 2.781 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046423 Css NA 0.3382 mg/L PBTK NA 50% Rat Human -DTXSID1046423 Css NA 1.656 mg/L PBTK NA 95% Rat Human -DTXSID1046425 Clint NA 9.199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046425 Fup NA 0.3733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046425 Vd NA 0.3204 L/kg 1compartment NA NA Human Human +DTXSID1046423 TK.Half.Life NA 3.101 hours 1compartment NA NA Rat Human +DTXSID1046423 Css NA 0.07015 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046423 Css NA 0.3702 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046423 Css NA 0.04708 mg/L PBTK NA 50% Rat Human +DTXSID1046423 Css NA 0.2361 mg/L PBTK NA 95% Rat Human +DTXSID1046425 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046425 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046425 Vd NA 0.3632 L/kg 1compartment NA NA Human Human DTXSID1046425 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046425 TK.Half.Life NA 0.5622 hours 1compartment NA NA Human Human -DTXSID1046425 Css NA 0.1362 mg/L 3compartmentss NA 50% Human Human -DTXSID1046425 Css NA 0.8989 mg/L 3compartmentss NA 95% Human Human -DTXSID1046425 Css NA 0.09011 mg/L PBTK NA 50% Human Human -DTXSID1046425 Css NA 0.566 mg/L PBTK NA 95% Human Human -DTXSID1046425 Clint NA 9.199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046425 Fup NA 0.3733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046425 Vd NA 0.331 L/kg 1compartment NA NA Rat Human +DTXSID1046425 TK.Half.Life NA 4.767 hours 1compartment NA NA Human Human +DTXSID1046425 Css NA 0.8618 mg/L 3compartmentss NA 50% Human Human +DTXSID1046425 Css NA 4.491 mg/L 3compartmentss NA 95% Human Human +DTXSID1046425 Css NA 0.6041 mg/L PBTK NA 50% Human Human +DTXSID1046425 Css NA 2.732 mg/L PBTK NA 95% Human Human +DTXSID1046425 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046425 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046425 Vd NA 0.3765 L/kg 1compartment NA NA Rat Human DTXSID1046425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046425 TK.Half.Life NA 0.3177 hours 1compartment NA NA Rat Human -DTXSID1046425 Css NA 0.0707 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046425 Css NA 0.3579 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046425 Css NA 0.04448 mg/L PBTK NA 50% Rat Human -DTXSID1046425 Css NA 0.2086 mg/L PBTK NA 95% Rat Human -DTXSID1046427 Clint NA 130.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046427 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046427 Vd NA 1.888 L/kg 1compartment NA NA Human Human +DTXSID1046425 TK.Half.Life NA 1.684 hours 1compartment NA NA Rat Human +DTXSID1046425 Css NA 0.004629 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046425 Css NA 0.02482 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046425 Css NA 0.003068 mg/L PBTK NA 50% Rat Human +DTXSID1046425 Css NA 0.01481 mg/L PBTK NA 95% Rat Human +DTXSID1046427 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046427 Fup 0.0584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046427 Vd NA 1.812 L/kg 1compartment NA NA Human Human DTXSID1046427 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046427 TK.Half.Life NA 3.804 hours 1compartment NA NA Human Human -DTXSID1046427 Css NA 0.1944 mg/L 3compartmentss NA 50% Human Human -DTXSID1046427 Css NA 1.848 mg/L 3compartmentss NA 95% Human Human -DTXSID1046427 Css NA 0.127 mg/L PBTK NA 50% Human Human -DTXSID1046427 Css NA 1.13 mg/L PBTK NA 95% Human Human -DTXSID1046427 Clint NA 130.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046427 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046427 Vd NA 1.484 L/kg 1compartment NA NA Rat Human +DTXSID1046427 TK.Half.Life NA 6.022 hours 1compartment NA NA Human Human +DTXSID1046427 Css NA 0.3853 mg/L 3compartmentss NA 50% Human Human +DTXSID1046427 Css NA 3.145 mg/L 3compartmentss NA 95% Human Human +DTXSID1046427 Css NA 0.2696 mg/L PBTK NA 50% Human Human +DTXSID1046427 Css NA 2.047 mg/L PBTK NA 95% Human Human +DTXSID1046427 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046427 Fup 0.0584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046427 Vd NA 1.601 L/kg 1compartment NA NA Rat Human DTXSID1046427 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046427 TK.Half.Life NA 1.433 hours 1compartment NA NA Rat Human -DTXSID1046427 Css NA 0.1095 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046427 Css NA 0.897 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046427 Css NA 0.06777 mg/L PBTK NA 50% Rat Human -DTXSID1046427 Css NA 0.5242 mg/L PBTK NA 95% Rat Human -DTXSID1046429 Clint NA 452.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046429 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046429 Vd NA 3.003 L/kg 1compartment NA NA Human Human -DTXSID1046429 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046429 TK.Half.Life NA 5.743 hours 1compartment NA NA Human Human -DTXSID1046429 Css NA 0.143 mg/L 3compartmentss NA 50% Human Human -DTXSID1046429 Css NA 0.9087 mg/L 3compartmentss NA 95% Human Human -DTXSID1046429 Css NA 0.09774 mg/L PBTK NA 50% Human Human -DTXSID1046429 Css NA 0.6027 mg/L PBTK NA 95% Human Human -DTXSID1046429 Clint NA 452.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046429 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046429 Vd NA 2.248 L/kg 1compartment NA NA Rat Human -DTXSID1046429 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046429 TK.Half.Life NA 1.309 hours 1compartment NA NA Rat Human -DTXSID1046429 Css NA 0.08125 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046429 Css NA 0.4519 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046429 Css NA 0.05322 mg/L PBTK NA 50% Rat Human -DTXSID1046429 Css NA 0.2816 mg/L PBTK NA 95% Rat Human -DTXSID1046471 Clint NA 11.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046471 Fup NA 0.2884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046471 Vd NA 3.199 L/kg 1compartment NA NA Human Human +DTXSID1046427 TK.Half.Life NA 2.972 hours 1compartment NA NA Rat Human +DTXSID1046427 Css NA 0.04952 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046427 Css NA 0.329 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046427 Css NA 0.03438 mg/L PBTK NA 50% Rat Human +DTXSID1046427 Css NA 0.2083 mg/L PBTK NA 95% Rat Human +DTXSID1046429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046429 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046429 Vd NA 3.072 L/kg 1compartment NA NA Human Human +DTXSID1046429 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID1046429 TK.Half.Life NA 69.61 hours 1compartment NA NA Human Human +DTXSID1046429 Css NA 2.706 mg/L 3compartmentss NA 50% Human Human +DTXSID1046429 Css NA 18.4 mg/L 3compartmentss NA 95% Human Human +DTXSID1046429 Css NA 1.868 mg/L PBTK NA 50% Human Human +DTXSID1046429 Css NA 12.32 mg/L PBTK NA 95% Human Human +DTXSID1046429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046429 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046429 Vd NA 2.302 L/kg 1compartment NA NA Rat Human +DTXSID1046429 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID1046429 TK.Half.Life NA 10.12 hours 1compartment NA NA Rat Human +DTXSID1046429 Css NA 0.3566 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046429 Css NA 1.971 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046429 Css NA 0.2436 mg/L PBTK NA 50% Rat Human +DTXSID1046429 Css NA 1.303 mg/L PBTK NA 95% Rat Human +DTXSID1046471 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046471 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046471 Vd NA 2.401 L/kg 1compartment NA NA Human Human DTXSID1046471 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046471 TK.Half.Life NA 4.321 hours 1compartment NA NA Human Human -DTXSID1046471 Css NA 0.07112 mg/L 3compartmentss NA 50% Human Human -DTXSID1046471 Css NA 0.5681 mg/L 3compartmentss NA 95% Human Human -DTXSID1046471 Css NA 0.08344 mg/L PBTK NA 50% Human Human -DTXSID1046471 Css NA 0.515 mg/L PBTK NA 95% Human Human -DTXSID1046471 Clint NA 11.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046471 Fup NA 0.2884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046471 Vd NA 3.213 L/kg 1compartment NA NA Rat Human +DTXSID1046471 TK.Half.Life NA 4.955 hours 1compartment NA NA Human Human +DTXSID1046471 Css NA 0.1156 mg/L 3compartmentss NA 50% Human Human +DTXSID1046471 Css NA 0.8457 mg/L 3compartmentss NA 95% Human Human +DTXSID1046471 Css NA 0.1191 mg/L PBTK NA 50% Human Human +DTXSID1046471 Css NA 0.7072 mg/L PBTK NA 95% Human Human +DTXSID1046471 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046471 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046471 Vd NA 2.401 L/kg 1compartment NA NA Rat Human DTXSID1046471 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046471 TK.Half.Life NA 2.546 hours 1compartment NA NA Rat Human -DTXSID1046471 Css NA 0.03578 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046471 Css NA 0.2292 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046471 Css NA 0.04212 mg/L PBTK NA 50% Rat Human -DTXSID1046471 Css NA 0.1999 mg/L PBTK NA 95% Rat Human -DTXSID1046475 Clint NA 447.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046475 Fup NA 0.1214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046475 Vd NA 2.115 L/kg 1compartment NA NA Human Human +DTXSID1046471 TK.Half.Life NA 2.907 hours 1compartment NA NA Rat Human +DTXSID1046471 Css NA 0.004854 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046471 Css NA 0.04351 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046471 Css NA 0.005259 mg/L PBTK NA 50% Rat Human +DTXSID1046471 Css NA 0.03562 mg/L PBTK NA 95% Rat Human +DTXSID1046475 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046475 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046475 Vd NA 1.898 L/kg 1compartment NA NA Human Human DTXSID1046475 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046475 TK.Half.Life NA 1.75 hours 1compartment NA NA Human Human -DTXSID1046475 Css NA 0.01218 mg/L 3compartmentss NA 50% Human Human -DTXSID1046475 Css NA 0.09932 mg/L 3compartmentss NA 95% Human Human -DTXSID1046475 Css NA 0.008937 mg/L PBTK NA 50% Human Human -DTXSID1046475 Css NA 0.06622 mg/L PBTK NA 95% Human Human -DTXSID1046475 Clint NA 447.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046475 Fup NA 0.1214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046475 Vd NA 1.788 L/kg 1compartment NA NA Rat Human +DTXSID1046475 TK.Half.Life NA 5.449 hours 1compartment NA NA Human Human +DTXSID1046475 Css NA 0.2368 mg/L 3compartmentss NA 50% Human Human +DTXSID1046475 Css NA 1.49 mg/L 3compartmentss NA 95% Human Human +DTXSID1046475 Css NA 0.1972 mg/L PBTK NA 50% Human Human +DTXSID1046475 Css NA 1.089 mg/L PBTK NA 95% Human Human +DTXSID1046475 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046475 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046475 Vd NA 1.772 L/kg 1compartment NA NA Rat Human DTXSID1046475 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046475 TK.Half.Life NA 0.6595 hours 1compartment NA NA Rat Human -DTXSID1046475 Css NA 0.006842 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046475 Css NA 0.0469 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046475 Css NA 0.004805 mg/L PBTK NA 50% Rat Human -DTXSID1046475 Css NA 0.02983 mg/L PBTK NA 95% Rat Human -DTXSID1046477 Clint NA 8.032 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046477 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046477 Vd NA 0.2511 L/kg 1compartment NA NA Human Human +DTXSID1046475 TK.Half.Life NA 2.788 hours 1compartment NA NA Rat Human +DTXSID1046475 Css NA 0.02766 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046475 Css NA 0.1259 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046475 Css NA 0.02334 mg/L PBTK NA 50% Rat Human +DTXSID1046475 Css NA 0.08978 mg/L PBTK NA 95% Rat Human +DTXSID1046477 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046477 Fup 0.0606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046477 Vd NA 0.3079 L/kg 1compartment NA NA Human Human DTXSID1046477 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046477 TK.Half.Life NA 3.618 hours 1compartment NA NA Human Human -DTXSID1046477 Css NA 2.604 mg/L 3compartmentss NA 50% Human Human -DTXSID1046477 Css NA 19.59 mg/L 3compartmentss NA 95% Human Human -DTXSID1046477 Css NA 1.558 mg/L PBTK NA 50% Human Human -DTXSID1046477 Css NA 11.53 mg/L PBTK NA 95% Human Human -DTXSID1046477 Clint NA 8.032 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046477 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046477 Vd NA 0.2454 L/kg 1compartment NA NA Rat Human +DTXSID1046477 TK.Half.Life NA 3.132 hours 1compartment NA NA Human Human +DTXSID1046477 Css NA 1.463 mg/L 3compartmentss NA 50% Human Human +DTXSID1046477 Css NA 9.981 mg/L 3compartmentss NA 95% Human Human +DTXSID1046477 Css NA 0.8992 mg/L PBTK NA 50% Human Human +DTXSID1046477 Css NA 5.896 mg/L PBTK NA 95% Human Human +DTXSID1046477 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046477 Fup 0.0606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046477 Vd NA 0.3015 L/kg 1compartment NA NA Rat Human DTXSID1046477 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046477 TK.Half.Life NA 2.257 hours 1compartment NA NA Rat Human -DTXSID1046477 Css NA 1.426 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046477 Css NA 7.918 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046477 Css NA 0.7978 mg/L PBTK NA 50% Rat Human -DTXSID1046477 Css NA 4.322 mg/L PBTK NA 95% Rat Human -DTXSID1046479 Clint NA 4.076 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046479 Fup NA 0.0565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046479 Vd NA 0.3245 L/kg 1compartment NA NA Human Human +DTXSID1046477 TK.Half.Life NA 1.907 hours 1compartment NA NA Rat Human +DTXSID1046477 Css NA 0.0656 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046477 Css NA 0.5328 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046477 Css NA 0.03888 mg/L PBTK NA 50% Rat Human +DTXSID1046477 Css NA 0.3052 mg/L PBTK NA 95% Rat Human +DTXSID1046479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046479 Fup 0.0661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046479 Vd NA 0.3969 L/kg 1compartment NA NA Human Human DTXSID1046479 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046479 TK.Half.Life NA 5.023 hours 1compartment NA NA Human Human -DTXSID1046479 Css NA 2.593 mg/L 3compartmentss NA 50% Human Human -DTXSID1046479 Css NA 16.28 mg/L 3compartmentss NA 95% Human Human -DTXSID1046479 Css NA 1.6 mg/L PBTK NA 50% Human Human -DTXSID1046479 Css NA 9.669 mg/L PBTK NA 95% Human Human -DTXSID1046479 Clint NA 4.076 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046479 Fup NA 0.0565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046479 Vd NA 0.3174 L/kg 1compartment NA NA Rat Human +DTXSID1046479 TK.Half.Life NA 1.379 hours 1compartment NA NA Human Human +DTXSID1046479 Css NA 0.4119 mg/L 3compartmentss NA 50% Human Human +DTXSID1046479 Css NA 3.055 mg/L 3compartmentss NA 95% Human Human +DTXSID1046479 Css NA 0.2631 mg/L PBTK NA 50% Human Human +DTXSID1046479 Css NA 1.89 mg/L PBTK NA 95% Human Human +DTXSID1046479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046479 Fup 0.0661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046479 Vd NA 0.3869 L/kg 1compartment NA NA Rat Human DTXSID1046479 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046479 TK.Half.Life NA 2.972 hours 1compartment NA NA Rat Human -DTXSID1046479 Css NA 1.314 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046479 Css NA 6.447 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046479 Css NA 0.765 mg/L PBTK NA 50% Rat Human -DTXSID1046479 Css NA 3.589 mg/L PBTK NA 95% Rat Human -DTXSID1046500 Clint NA 6.271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046500 Fup NA 0.0403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046500 Vd NA 0.9569 L/kg 1compartment NA NA Human Human -DTXSID1046500 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1046500 TK.Half.Life NA 14.02 hours 1compartment NA NA Human Human -DTXSID1046500 Css NA 2.45 mg/L 3compartmentss NA 50% Human Human -DTXSID1046500 Css NA 20.03 mg/L 3compartmentss NA 95% Human Human -DTXSID1046500 Css NA 1.542 mg/L PBTK NA 50% Human Human -DTXSID1046500 Css NA 11.94 mg/L PBTK NA 95% Human Human -DTXSID1046500 Clint NA 6.271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046500 Fup NA 0.0403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046500 Vd NA 0.7313 L/kg 1compartment NA NA Rat Human +DTXSID1046479 TK.Half.Life NA 0.8308 hours 1compartment NA NA Rat Human +DTXSID1046479 Css NA 0.05402 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046479 Css NA 0.3013 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046479 Css NA 0.03356 mg/L PBTK NA 50% Rat Human +DTXSID1046479 Css NA 0.1806 mg/L PBTK NA 95% Rat Human +DTXSID1046500 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046500 Fup 0.0449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046500 Vd NA 0.7562 L/kg 1compartment NA NA Human Human +DTXSID1046500 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046500 TK.Half.Life NA 3.501 hours 1compartment NA NA Human Human +DTXSID1046500 Css NA 0.5651 mg/L 3compartmentss NA 50% Human Human +DTXSID1046500 Css NA 4.689 mg/L 3compartmentss NA 95% Human Human +DTXSID1046500 Css NA 0.3538 mg/L PBTK NA 50% Human Human +DTXSID1046500 Css NA 2.758 mg/L PBTK NA 95% Human Human +DTXSID1046500 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046500 Fup 0.0449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046500 Vd NA 0.5896 L/kg 1compartment NA NA Rat Human DTXSID1046500 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046500 TK.Half.Life NA 6.15 hours 1compartment NA NA Rat Human -DTXSID1046500 Css NA 1.314 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046500 Css NA 8.023 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046500 Css NA 0.7736 mg/L PBTK NA 50% Rat Human -DTXSID1046500 Css NA 4.447 mg/L PBTK NA 95% Rat Human -DTXSID1046502 Clint NA 2.288 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046502 Fup NA 0.4504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046502 Vd NA 5.149 L/kg 1compartment NA NA Human Human -DTXSID1046502 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1046502 TK.Half.Life NA 24.72 hours 1compartment NA NA Human Human -DTXSID1046502 Css NA 0.3102 mg/L 3compartmentss NA 50% Human Human -DTXSID1046502 Css NA 1.82 mg/L 3compartmentss NA 95% Human Human -DTXSID1046502 Css NA 0.3998 mg/L PBTK NA 50% Human Human -DTXSID1046502 Css NA 1.807 mg/L PBTK NA 95% Human Human -DTXSID1046502 Clint NA 2.288 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046502 Fup NA 0.4504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046502 Vd NA 4.897 L/kg 1compartment NA NA Rat Human -DTXSID1046502 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1046502 TK.Half.Life NA 8.42 hours 1compartment NA NA Rat Human -DTXSID1046502 Css NA 0.143 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046502 Css NA 0.639 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046502 Css NA 0.1849 mg/L PBTK NA 50% Rat Human -DTXSID1046502 Css NA 0.5915 mg/L PBTK NA 95% Rat Human -DTXSID1046504 Clint NA 41.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046504 Fup NA 0.0875 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046504 Vd NA 1.198 L/kg 1compartment NA NA Human Human +DTXSID1046500 TK.Half.Life NA 1.639 hours 1compartment NA NA Rat Human +DTXSID1046500 Css NA 0.02785 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046500 Css NA 0.2465 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046500 Css NA 0.01679 mg/L PBTK NA 50% Rat Human +DTXSID1046500 Css NA 0.1421 mg/L PBTK NA 95% Rat Human +DTXSID1046502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046502 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046502 Vd NA 2.508 L/kg 1compartment NA NA Human Human +DTXSID1046502 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046502 TK.Half.Life NA 2.901 hours 1compartment NA NA Human Human +DTXSID1046502 Css NA 0.05426 mg/L 3compartmentss NA 50% Human Human +DTXSID1046502 Css NA 0.4396 mg/L 3compartmentss NA 95% Human Human +DTXSID1046502 Css NA 0.05222 mg/L PBTK NA 50% Human Human +DTXSID1046502 Css NA 0.3574 mg/L PBTK NA 95% Human Human +DTXSID1046502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046502 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046502 Vd NA 2.516 L/kg 1compartment NA NA Rat Human +DTXSID1046502 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1046502 TK.Half.Life NA 1.607 hours 1compartment NA NA Rat Human +DTXSID1046502 Css NA 0.006579 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046502 Css NA 0.04261 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046502 Css NA 0.006552 mg/L PBTK NA 50% Rat Human +DTXSID1046502 Css NA 0.03429 mg/L PBTK NA 95% Rat Human +DTXSID1046504 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046504 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046504 Vd NA 4.589 L/kg 1compartment NA NA Human Human DTXSID1046504 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046504 TK.Half.Life NA 1.95 hours 1compartment NA NA Human Human -DTXSID1046504 Css NA 0.1351 mg/L 3compartmentss NA 50% Human Human -DTXSID1046504 Css NA 1.268 mg/L 3compartmentss NA 95% Human Human -DTXSID1046504 Css NA 0.09721 mg/L PBTK NA 50% Human Human -DTXSID1046504 Css NA 0.8221 mg/L PBTK NA 95% Human Human -DTXSID1046504 Clint NA 41.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046504 Fup NA 0.0875 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046504 Vd NA 1.171 L/kg 1compartment NA NA Rat Human +DTXSID1046504 TK.Half.Life NA 5.479 hours 1compartment NA NA Human Human +DTXSID1046504 Css NA 0.05504 mg/L 3compartmentss NA 50% Human Human +DTXSID1046504 Css NA 0.413 mg/L 3compartmentss NA 95% Human Human +DTXSID1046504 Css NA 0.06242 mg/L PBTK NA 50% Human Human +DTXSID1046504 Css NA 0.4053 mg/L PBTK NA 95% Human Human +DTXSID1046504 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046504 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046504 Vd NA 4.274 L/kg 1compartment NA NA Rat Human DTXSID1046504 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046504 TK.Half.Life NA 1.091 hours 1compartment NA NA Rat Human -DTXSID1046504 Css NA 0.0761 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046504 Css NA 0.5456 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046504 Css NA 0.05202 mg/L PBTK NA 50% Rat Human -DTXSID1046504 Css NA 0.3417 mg/L PBTK NA 95% Rat Human -DTXSID1046506 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046506 Fup NA 0.2383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046506 Vd NA 0.7213 L/kg 1compartment NA NA Human Human +DTXSID1046504 TK.Half.Life NA 2.082 hours 1compartment NA NA Rat Human +DTXSID1046504 Css NA 0.006666 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046504 Css NA 0.03916 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046504 Css NA 0.007898 mg/L PBTK NA 50% Rat Human +DTXSID1046504 Css NA 0.03873 mg/L PBTK NA 95% Rat Human +DTXSID1046506 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046506 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046506 Vd NA 0.5987 L/kg 1compartment NA NA Human Human DTXSID1046506 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046506 TK.Half.Life NA 2.671 hours 1compartment NA NA Human Human -DTXSID1046506 Css NA 0.3758 mg/L 3compartmentss NA 50% Human Human -DTXSID1046506 Css NA 2.198 mg/L 3compartmentss NA 95% Human Human -DTXSID1046506 Css NA 0.263 mg/L PBTK NA 50% Human Human -DTXSID1046506 Css NA 1.398 mg/L PBTK NA 95% Human Human -DTXSID1046506 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046506 Fup NA 0.2383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046506 Vd NA 0.6416 L/kg 1compartment NA NA Rat Human +DTXSID1046506 TK.Half.Life NA 1.709 hours 1compartment NA NA Human Human +DTXSID1046506 Css NA 0.2626 mg/L 3compartmentss NA 50% Human Human +DTXSID1046506 Css NA 1.605 mg/L 3compartmentss NA 95% Human Human +DTXSID1046506 Css NA 0.1824 mg/L PBTK NA 50% Human Human +DTXSID1046506 Css NA 1.032 mg/L PBTK NA 95% Human Human +DTXSID1046506 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046506 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046506 Vd NA 0.5601 L/kg 1compartment NA NA Rat Human DTXSID1046506 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046506 TK.Half.Life NA 1.349 hours 1compartment NA NA Rat Human -DTXSID1046506 Css NA 0.1909 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046506 Css NA 0.7957 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046506 Css NA 0.1274 mg/L PBTK NA 50% Rat Human -DTXSID1046506 Css NA 0.4801 mg/L PBTK NA 95% Rat Human -DTXSID1046508 Clint NA 81.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046508 Fup NA 0.0499 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046508 Vd NA 2.905 L/kg 1compartment NA NA Human Human -DTXSID1046508 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046508 TK.Half.Life NA 9.476 hours 1compartment NA NA Human Human -DTXSID1046508 Css NA 0.3332 mg/L 3compartmentss NA 50% Human Human -DTXSID1046508 Css NA 2.099 mg/L 3compartmentss NA 95% Human Human -DTXSID1046508 Css NA 0.232 mg/L PBTK NA 50% Human Human -DTXSID1046508 Css NA 1.398 mg/L PBTK NA 95% Human Human -DTXSID1046508 Clint NA 81.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046508 Fup NA 0.0499 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046508 Vd NA 2.206 L/kg 1compartment NA NA Rat Human -DTXSID1046508 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046508 TK.Half.Life NA 2.137 hours 1compartment NA NA Rat Human -DTXSID1046508 Css NA 0.1852 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046508 Css NA 1.027 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046508 Css NA 0.1229 mg/L PBTK NA 50% Rat Human -DTXSID1046508 Css NA 0.6485 mg/L PBTK NA 95% Rat Human -DTXSID1046550 Clint NA 14.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046550 Fup NA 0.0861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046550 Vd NA 0.4593 L/kg 1compartment NA NA Human Human +DTXSID1046506 TK.Half.Life NA 0.9167 hours 1compartment NA NA Rat Human +DTXSID1046506 Css NA 0.03163 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046506 Css NA 0.1381 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046506 Css NA 0.02172 mg/L PBTK NA 50% Rat Human +DTXSID1046506 Css NA 0.08703 mg/L PBTK NA 95% Rat Human +DTXSID1046508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046508 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046508 Vd NA 3.12 L/kg 1compartment NA NA Human Human +DTXSID1046508 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1046508 TK.Half.Life NA 20.54 hours 1compartment NA NA Human Human +DTXSID1046508 Css NA 0.6706 mg/L 3compartmentss NA 50% Human Human +DTXSID1046508 Css NA 4.232 mg/L 3compartmentss NA 95% Human Human +DTXSID1046508 Css NA 0.488 mg/L PBTK NA 50% Human Human +DTXSID1046508 Css NA 2.956 mg/L PBTK NA 95% Human Human +DTXSID1046508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046508 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046508 Vd NA 2.394 L/kg 1compartment NA NA Rat Human +DTXSID1046508 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1046508 TK.Half.Life NA 3.723 hours 1compartment NA NA Rat Human +DTXSID1046508 Css NA 0.08588 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046508 Css NA 0.4368 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046508 Css NA 0.06188 mg/L PBTK NA 50% Rat Human +DTXSID1046508 Css NA 0.3104 mg/L PBTK NA 95% Rat Human +DTXSID1046550 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046550 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046550 Vd NA 0.6089 L/kg 1compartment NA NA Human Human DTXSID1046550 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046550 TK.Half.Life NA 1.757 hours 1compartment NA NA Human Human -DTXSID1046550 Css NA 0.5151 mg/L 3compartmentss NA 50% Human Human -DTXSID1046550 Css NA 4.005 mg/L 3compartmentss NA 95% Human Human -DTXSID1046550 Css NA 0.3209 mg/L PBTK NA 50% Human Human -DTXSID1046550 Css NA 2.383 mg/L PBTK NA 95% Human Human -DTXSID1046550 Clint NA 14.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046550 Fup NA 0.0861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046550 Vd NA 0.4016 L/kg 1compartment NA NA Rat Human +DTXSID1046550 TK.Half.Life NA 1.559 hours 1compartment NA NA Human Human +DTXSID1046550 Css NA 0.1958 mg/L 3compartmentss NA 50% Human Human +DTXSID1046550 Css NA 1.24 mg/L 3compartmentss NA 95% Human Human +DTXSID1046550 Css NA 0.1392 mg/L PBTK NA 50% Human Human +DTXSID1046550 Css NA 0.8312 mg/L PBTK NA 95% Human Human +DTXSID1046550 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046550 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046550 Vd NA 0.5783 L/kg 1compartment NA NA Rat Human DTXSID1046550 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046550 TK.Half.Life NA 0.9342 hours 1compartment NA NA Rat Human -DTXSID1046550 Css NA 0.2888 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046550 Css NA 1.667 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046550 Css NA 0.1682 mg/L PBTK NA 50% Rat Human -DTXSID1046550 Css NA 0.9317 mg/L PBTK NA 95% Rat Human +DTXSID1046550 TK.Half.Life NA 0.8414 hours 1compartment NA NA Rat Human +DTXSID1046550 Css NA 0.008444 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046550 Css NA 0.06476 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046550 Css NA 0.005985 mg/L PBTK NA 50% Rat Human +DTXSID1046550 Css NA 0.04084 mg/L PBTK NA 95% Rat Human DTXSID1046552 Clint NA 394.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046552 Fup NA 0.3253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046552 Vd NA 0.6032 L/kg 1compartment NA NA Human Human +DTXSID1046552 Vd NA 0.3023 L/kg 1compartment NA NA Human Human DTXSID1046552 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046552 TK.Half.Life NA 0.4837 hours 1compartment NA NA Human Human -DTXSID1046552 Css NA 0.00384 mg/L 3compartmentss NA 50% Human Human -DTXSID1046552 Css NA 0.03024 mg/L 3compartmentss NA 95% Human Human -DTXSID1046552 Css NA 0.002686 mg/L PBTK NA 50% Human Human -DTXSID1046552 Css NA 0.01989 mg/L PBTK NA 95% Human Human +DTXSID1046552 TK.Half.Life NA 0.2612 hours 1compartment NA NA Human Human +DTXSID1046552 Css NA 0.001256 mg/L 3compartmentss NA 50% Human Human +DTXSID1046552 Css NA 0.02239 mg/L 3compartmentss NA 95% Human Human +DTXSID1046552 Css NA 0.0008169 mg/L PBTK NA 50% Human Human +DTXSID1046552 Css NA 0.01395 mg/L PBTK NA 95% Human Human DTXSID1046552 Clint NA 394.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046552 Fup NA 0.3253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046552 Vd NA 0.5838 L/kg 1compartment NA NA Rat Human +DTXSID1046552 Vd NA 0.3149 L/kg 1compartment NA NA Rat Human DTXSID1046552 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046552 TK.Half.Life NA 0.2072 hours 1compartment NA NA Rat Human -DTXSID1046552 Css NA 0.002128 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046552 Css NA 0.01407 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046552 Css NA 0.001423 mg/L PBTK NA 50% Rat Human -DTXSID1046552 Css NA 0.008799 mg/L PBTK NA 95% Rat Human -DTXSID1046556 Clint NA 87.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046556 Fup NA 0.0049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046556 Vd NA 2.725 L/kg 1compartment NA NA Human Human -DTXSID1046556 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1046556 TK.Half.Life NA 18.63 hours 1compartment NA NA Human Human -DTXSID1046556 Css NA 0.881 mg/L 3compartmentss NA 50% Human Human -DTXSID1046556 Css NA 6.047 mg/L 3compartmentss NA 95% Human Human -DTXSID1046556 Css NA 0.5875 mg/L PBTK NA 50% Human Human -DTXSID1046556 Css NA 3.845 mg/L PBTK NA 95% Human Human -DTXSID1046556 Clint NA 87.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046556 Fup NA 0.0049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046556 Vd NA 2.032 L/kg 1compartment NA NA Rat Human -DTXSID1046556 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046556 TK.Half.Life NA 4.058 hours 1compartment NA NA Rat Human -DTXSID1046556 Css NA 0.4966 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046556 Css NA 2.917 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046556 Css NA 0.3142 mg/L PBTK NA 50% Rat Human -DTXSID1046556 Css NA 1.775 mg/L PBTK NA 95% Rat Human -DTXSID1046558 Clint NA 10.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046558 Fup NA 0.1565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046558 Vd NA 2.05 L/kg 1compartment NA NA Human Human +DTXSID1046552 TK.Half.Life NA 0.1201 hours 1compartment NA NA Rat Human +DTXSID1046552 Css NA 3.872e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046552 Css NA 0.0009313 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046552 Css NA 2.456e-05 mg/L PBTK NA 50% Rat Human +DTXSID1046552 Css NA 0.0005614 mg/L PBTK NA 95% Rat Human +DTXSID1046556 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046556 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046556 Vd NA 2.939 L/kg 1compartment NA NA Human Human +DTXSID1046556 Days.Css NA 45 Days PBTK NA NA Human Human +DTXSID1046556 TK.Half.Life NA 219.5 hours 1compartment NA NA Human Human +DTXSID1046556 Css NA 8.65 mg/L 3compartmentss NA 50% Human Human +DTXSID1046556 Css NA 59.46 mg/L 3compartmentss NA 95% Human Human +DTXSID1046556 Css NA 5.895 mg/L PBTK NA 50% Human Human +DTXSID1046556 Css NA 39.26 mg/L PBTK NA 95% Human Human +DTXSID1046556 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046556 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046556 Vd NA 2.199 L/kg 1compartment NA NA Rat Human +DTXSID1046556 Days.Css NA 24 Days PBTK NA NA Rat Human +DTXSID1046556 TK.Half.Life NA 35.99 hours 1compartment NA NA Rat Human +DTXSID1046556 Css NA 0.4437 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046556 Css NA 3.005 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046556 Css NA 0.2914 mg/L PBTK NA 50% Rat Human +DTXSID1046556 Css NA 1.901 mg/L PBTK NA 95% Rat Human +DTXSID1046558 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046558 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046558 Vd NA 1.829 L/kg 1compartment NA NA Human Human DTXSID1046558 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046558 TK.Half.Life NA 8.575 hours 1compartment NA NA Human Human -DTXSID1046558 Css NA 0.4711 mg/L 3compartmentss NA 50% Human Human -DTXSID1046558 Css NA 2.925 mg/L 3compartmentss NA 95% Human Human -DTXSID1046558 Css NA 0.3305 mg/L PBTK NA 50% Human Human -DTXSID1046558 Css NA 1.926 mg/L PBTK NA 95% Human Human -DTXSID1046558 Clint NA 10.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046558 Fup NA 0.1565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046558 Vd NA 1.567 L/kg 1compartment NA NA Rat Human +DTXSID1046558 TK.Half.Life NA 5.1 hours 1compartment NA NA Human Human +DTXSID1046558 Css NA 0.2891 mg/L 3compartmentss NA 50% Human Human +DTXSID1046558 Css NA 2.051 mg/L 3compartmentss NA 95% Human Human +DTXSID1046558 Css NA 0.1952 mg/L PBTK NA 50% Human Human +DTXSID1046558 Css NA 1.296 mg/L PBTK NA 95% Human Human +DTXSID1046558 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046558 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046558 Vd NA 1.395 L/kg 1compartment NA NA Rat Human DTXSID1046558 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046558 TK.Half.Life NA 2.789 hours 1compartment NA NA Rat Human -DTXSID1046558 Css NA 0.2514 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046558 Css NA 1.195 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046558 Css NA 0.1685 mg/L PBTK NA 50% Rat Human -DTXSID1046558 Css NA 0.7534 mg/L PBTK NA 95% Rat Human -DTXSID1046631 Clint NA 30.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046631 Fup NA 0.065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046631 Vd NA 2.776 L/kg 1compartment NA NA Human Human +DTXSID1046558 TK.Half.Life NA 1.802 hours 1compartment NA NA Rat Human +DTXSID1046558 Css NA 0.03637 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046558 Css NA 0.216 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046558 Css NA 0.02428 mg/L PBTK NA 50% Rat Human +DTXSID1046558 Css NA 0.1345 mg/L PBTK NA 95% Rat Human +DTXSID1046631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046631 Fup 0.0774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046631 Vd NA 2.755 L/kg 1compartment NA NA Human Human DTXSID1046631 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046631 TK.Half.Life NA 7.525 hours 1compartment NA NA Human Human -DTXSID1046631 Css NA 0.2642 mg/L 3compartmentss NA 50% Human Human -DTXSID1046631 Css NA 1.891 mg/L 3compartmentss NA 95% Human Human -DTXSID1046631 Css NA 0.198 mg/L PBTK NA 50% Human Human -DTXSID1046631 Css NA 1.326 mg/L PBTK NA 95% Human Human -DTXSID1046631 Clint NA 30.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046631 Fup NA 0.065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046631 Vd NA 2.292 L/kg 1compartment NA NA Rat Human +DTXSID1046631 TK.Half.Life NA 8.364 hours 1compartment NA NA Human Human +DTXSID1046631 Css NA 0.3022 mg/L 3compartmentss NA 50% Human Human +DTXSID1046631 Css NA 2.179 mg/L 3compartmentss NA 95% Human Human +DTXSID1046631 Css NA 0.23 mg/L PBTK NA 50% Human Human +DTXSID1046631 Css NA 1.535 mg/L PBTK NA 95% Human Human +DTXSID1046631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046631 Fup 0.0774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046631 Vd NA 2.319 L/kg 1compartment NA NA Rat Human DTXSID1046631 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046631 TK.Half.Life NA 2.559 hours 1compartment NA NA Rat Human -DTXSID1046631 Css NA 0.1465 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046631 Css NA 0.8407 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046631 Css NA 0.1047 mg/L PBTK NA 50% Rat Human -DTXSID1046631 Css NA 0.5529 mg/L PBTK NA 95% Rat Human -DTXSID1046633 Clint NA 43.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046633 Fup NA 0.1944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046633 Vd NA 2.645 L/kg 1compartment NA NA Human Human +DTXSID1046631 TK.Half.Life NA 3.043 hours 1compartment NA NA Rat Human +DTXSID1046631 Css NA 0.03867 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046631 Css NA 0.2297 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046631 Css NA 0.02943 mg/L PBTK NA 50% Rat Human +DTXSID1046631 Css NA 0.1581 mg/L PBTK NA 95% Rat Human +DTXSID1046633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046633 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046633 Vd NA 2.477 L/kg 1compartment NA NA Human Human DTXSID1046633 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046633 TK.Half.Life NA 5.123 hours 1compartment NA NA Human Human -DTXSID1046633 Css NA 0.1422 mg/L 3compartmentss NA 50% Human Human -DTXSID1046633 Css NA 0.8985 mg/L 3compartmentss NA 95% Human Human -DTXSID1046633 Css NA 0.102 mg/L PBTK NA 50% Human Human -DTXSID1046633 Css NA 0.627 mg/L PBTK NA 95% Human Human -DTXSID1046633 Clint NA 43.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046633 Fup NA 0.1944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046633 Vd NA 2.012 L/kg 1compartment NA NA Rat Human +DTXSID1046633 TK.Half.Life NA 8.471 hours 1compartment NA NA Human Human +DTXSID1046633 Css NA 0.3461 mg/L 3compartmentss NA 50% Human Human +DTXSID1046633 Css NA 2.388 mg/L 3compartmentss NA 95% Human Human +DTXSID1046633 Css NA 0.2432 mg/L PBTK NA 50% Human Human +DTXSID1046633 Css NA 1.578 mg/L PBTK NA 95% Human Human +DTXSID1046633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046633 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046633 Vd NA 1.879 L/kg 1compartment NA NA Rat Human DTXSID1046633 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046633 TK.Half.Life NA 1.39 hours 1compartment NA NA Rat Human -DTXSID1046633 Css NA 0.07932 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046633 Css NA 0.4037 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046633 Css NA 0.05506 mg/L PBTK NA 50% Rat Human -DTXSID1046633 Css NA 0.2816 mg/L PBTK NA 95% Rat Human -DTXSID1046637 Clint NA 3.183 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046637 Fup NA 0.0219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046637 Vd NA 0.3023 L/kg 1compartment NA NA Human Human -DTXSID1046637 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1046637 TK.Half.Life NA 13.99 hours 1compartment NA NA Human Human -DTXSID1046637 Css NA 8.526 mg/L 3compartmentss NA 50% Human Human -DTXSID1046637 Css NA 63.17 mg/L 3compartmentss NA 95% Human Human -DTXSID1046637 Css NA 5.06 mg/L PBTK NA 50% Human Human -DTXSID1046637 Css NA 36.15 mg/L PBTK NA 95% Human Human -DTXSID1046637 Clint NA 3.183 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046637 Fup NA 0.0219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046637 Vd NA 0.2613 L/kg 1compartment NA NA Rat Human +DTXSID1046633 TK.Half.Life NA 2.321 hours 1compartment NA NA Rat Human +DTXSID1046633 Css NA 0.04416 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046633 Css NA 0.2394 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046633 Css NA 0.03068 mg/L PBTK NA 50% Rat Human +DTXSID1046633 Css NA 0.157 mg/L PBTK NA 95% Rat Human +DTXSID1046637 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046637 Fup 0.0607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046637 Vd NA 0.4793 L/kg 1compartment NA NA Human Human +DTXSID1046637 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046637 TK.Half.Life NA 4.77 hours 1compartment NA NA Human Human +DTXSID1046637 Css NA 0.8894 mg/L 3compartmentss NA 50% Human Human +DTXSID1046637 Css NA 6.251 mg/L 3compartmentss NA 95% Human Human +DTXSID1046637 Css NA 0.5426 mg/L PBTK NA 50% Human Human +DTXSID1046637 Css NA 3.652 mg/L PBTK NA 95% Human Human +DTXSID1046637 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046637 Fup 0.0607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046637 Vd NA 0.4029 L/kg 1compartment NA NA Rat Human DTXSID1046637 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046637 TK.Half.Life NA 7.211 hours 1compartment NA NA Rat Human -DTXSID1046637 Css NA 4.169 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046637 Css NA 26.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046637 Css NA 2.299 mg/L PBTK NA 50% Rat Human -DTXSID1046637 Css NA 14.09 mg/L PBTK NA 95% Rat Human -DTXSID1046639 Clint NA 8.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046639 Fup NA 0.2686 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046639 Vd NA 2.193 L/kg 1compartment NA NA Human Human +DTXSID1046637 TK.Half.Life NA 2.456 hours 1compartment NA NA Rat Human +DTXSID1046637 Css NA 0.009092 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046637 Css NA 0.05441 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046637 Css NA 0.005237 mg/L PBTK NA 50% Rat Human +DTXSID1046637 Css NA 0.03031 mg/L PBTK NA 95% Rat Human +DTXSID1046639 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046639 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046639 Vd NA 2.347 L/kg 1compartment NA NA Human Human DTXSID1046639 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046639 TK.Half.Life NA 5.724 hours 1compartment NA NA Human Human -DTXSID1046639 Css NA 0.217 mg/L 3compartmentss NA 50% Human Human -DTXSID1046639 Css NA 1.361 mg/L 3compartmentss NA 95% Human Human -DTXSID1046639 Css NA 0.1782 mg/L PBTK NA 50% Human Human -DTXSID1046639 Css NA 1.005 mg/L PBTK NA 95% Human Human -DTXSID1046639 Clint NA 8.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046639 Fup NA 0.2686 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046639 Vd NA 1.902 L/kg 1compartment NA NA Rat Human +DTXSID1046639 TK.Half.Life NA 3.01 hours 1compartment NA NA Human Human +DTXSID1046639 Css NA 0.06721 mg/L 3compartmentss NA 50% Human Human +DTXSID1046639 Css NA 0.4852 mg/L 3compartmentss NA 95% Human Human +DTXSID1046639 Css NA 0.0579 mg/L PBTK NA 50% Human Human +DTXSID1046639 Css NA 0.3728 mg/L PBTK NA 95% Human Human +DTXSID1046639 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046639 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046639 Vd NA 2.056 L/kg 1compartment NA NA Rat Human DTXSID1046639 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046639 TK.Half.Life NA 2.43 hours 1compartment NA NA Rat Human -DTXSID1046639 Css NA 0.1129 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046639 Css NA 0.4967 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046639 Css NA 0.08971 mg/L PBTK NA 50% Rat Human -DTXSID1046639 Css NA 0.3552 mg/L PBTK NA 95% Rat Human -DTXSID1046681 Clint NA 18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046681 Fup NA 0.0536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046681 Vd NA 2.242 L/kg 1compartment NA NA Human Human -DTXSID1046681 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1046681 TK.Half.Life NA 14.84 hours 1compartment NA NA Human Human -DTXSID1046681 Css NA 0.8858 mg/L 3compartmentss NA 50% Human Human -DTXSID1046681 Css NA 5.992 mg/L 3compartmentss NA 95% Human Human -DTXSID1046681 Css NA 0.5905 mg/L PBTK NA 50% Human Human -DTXSID1046681 Css NA 3.802 mg/L PBTK NA 95% Human Human -DTXSID1046681 Clint NA 18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046681 Fup NA 0.0536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046681 Vd NA 1.694 L/kg 1compartment NA NA Rat Human -DTXSID1046681 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046681 TK.Half.Life NA 4.443 hours 1compartment NA NA Rat Human -DTXSID1046681 Css NA 0.4912 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046681 Css NA 2.609 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046681 Css NA 0.3096 mg/L PBTK NA 50% Rat Human -DTXSID1046681 Css NA 1.584 mg/L PBTK NA 95% Rat Human +DTXSID1046639 TK.Half.Life NA 1.252 hours 1compartment NA NA Rat Human +DTXSID1046639 Css NA 0.008299 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046639 Css NA 0.04755 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046639 Css NA 0.007216 mg/L PBTK NA 50% Rat Human +DTXSID1046639 Css NA 0.03621 mg/L PBTK NA 95% Rat Human +DTXSID1046681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046681 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046681 Vd NA 3.128 L/kg 1compartment NA NA Human Human +DTXSID1046681 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID1046681 TK.Half.Life NA 59.6 hours 1compartment NA NA Human Human +DTXSID1046681 Css NA 2.164 mg/L 3compartmentss NA 50% Human Human +DTXSID1046681 Css NA 14.23 mg/L 3compartmentss NA 95% Human Human +DTXSID1046681 Css NA 1.511 mg/L PBTK NA 50% Human Human +DTXSID1046681 Css NA 9.656 mg/L PBTK NA 95% Human Human +DTXSID1046681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046681 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046681 Vd NA 2.348 L/kg 1compartment NA NA Rat Human +DTXSID1046681 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID1046681 TK.Half.Life NA 8.19 hours 1compartment NA NA Rat Human +DTXSID1046681 Css NA 0.2834 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046681 Css NA 1.578 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046681 Css NA 0.1965 mg/L PBTK NA 50% Rat Human +DTXSID1046681 Css NA 1.05 mg/L PBTK NA 95% Rat Human DTXSID1046683 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046683 Fup NA 0.2191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046683 Vd NA 3.121 L/kg 1compartment NA NA Human Human -DTXSID1046683 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID1046683 TK.Half.Life NA 2471 hours 1compartment NA NA Human Human -DTXSID1046683 Css NA 88.38 mg/L 3compartmentss NA 50% Human Human -DTXSID1046683 Css NA 245 mg/L 3compartmentss NA 95% Human Human -DTXSID1046683 Css NA 63.18 mg/L PBTK NA 50% Human Human -DTXSID1046683 Css NA 163.2 mg/L PBTK NA 95% Human Human +DTXSID1046683 Vd NA 0.3543 L/kg 1compartment NA NA Human Human +DTXSID1046683 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1046683 TK.Half.Life NA 10.47 hours 1compartment NA NA Human Human +DTXSID1046683 Css NA 3.075 mg/L 3compartmentss NA 50% Human Human +DTXSID1046683 Css NA 11.39 mg/L 3compartmentss NA 95% Human Human +DTXSID1046683 Css NA 2.025 mg/L PBTK NA 50% Human Human +DTXSID1046683 Css NA 6.908 mg/L PBTK NA 95% Human Human DTXSID1046683 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046683 Fup NA 0.2191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046683 Vd NA 2.358 L/kg 1compartment NA NA Rat Human -DTXSID1046683 Days.Css NA 165 Days PBTK NA NA Rat Human -DTXSID1046683 TK.Half.Life NA 169.7 hours 1compartment NA NA Rat Human -DTXSID1046683 Css NA 23.73 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046683 Css NA 52.81 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046683 Css NA 16.24 mg/L PBTK NA 50% Rat Human -DTXSID1046683 Css NA 32.34 mg/L PBTK NA 95% Rat Human +DTXSID1046683 Vd NA 0.3644 L/kg 1compartment NA NA Rat Human +DTXSID1046683 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1046683 TK.Half.Life NA 3.667 hours 1compartment NA NA Rat Human +DTXSID1046683 Css NA 0.05475 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046683 Css NA 0.3268 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046683 Css NA 0.03474 mg/L PBTK NA 50% Rat Human +DTXSID1046683 Css NA 0.1964 mg/L PBTK NA 95% Rat Human DTXSID1046685 Clint 3.81 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID1046685 Fup NA 0.0138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046685 Vd NA 0.2087 L/kg 1compartment NA NA Human Human -DTXSID1046685 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1046685 TK.Half.Life NA 13.49 hours 1compartment NA NA Human Human -DTXSID1046685 Css NA 11.8 mg/L 3compartmentss NA 50% Human Human -DTXSID1046685 Css NA 92.69 mg/L 3compartmentss NA 95% Human Human -DTXSID1046685 Css NA 7.038 mg/L PBTK NA 50% Human Human -DTXSID1046685 Css NA 53.69 mg/L PBTK NA 95% Human Human +DTXSID1046685 Fup 0.0744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046685 Vd NA 1.504 L/kg 1compartment NA NA Human Human +DTXSID1046685 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1046685 TK.Half.Life NA 22.12 hours 1compartment NA NA Human Human +DTXSID1046685 Css NA 1.886 mg/L 3compartmentss NA 50% Human Human +DTXSID1046685 Css NA 10.98 mg/L 3compartmentss NA 95% Human Human +DTXSID1046685 Css NA 1.236 mg/L PBTK NA 50% Human Human +DTXSID1046685 Css NA 6.722 mg/L PBTK NA 95% Human Human DTXSID1046685 Clint 3.81 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID1046685 Fup NA 0.0138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046685 Vd NA 0.2028 L/kg 1compartment NA NA Rat Human -DTXSID1046685 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046685 TK.Half.Life NA 8.005 hours 1compartment NA NA Rat Human -DTXSID1046685 Css NA 6.011 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046685 Css NA 38.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046685 Css NA 3.314 mg/L PBTK NA 50% Rat Human -DTXSID1046685 Css NA 20.97 mg/L PBTK NA 95% Rat Human -DTXSID1046687 Clint NA 35.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046687 Fup NA 0.1485 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046687 Vd NA 0.7948 L/kg 1compartment NA NA Human Human +DTXSID1046685 Fup 0.0744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046685 Vd NA 1.134 L/kg 1compartment NA NA Rat Human +DTXSID1046685 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1046685 TK.Half.Life NA 8 hours 1compartment NA NA Rat Human +DTXSID1046685 Css NA 0.08406 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046685 Css NA 0.5553 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046685 Css NA 0.05336 mg/L PBTK NA 50% Rat Human +DTXSID1046685 Css NA 0.3343 mg/L PBTK NA 95% Rat Human +DTXSID1046687 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046687 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046687 Vd NA 1.323 L/kg 1compartment NA NA Human Human DTXSID1046687 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046687 TK.Half.Life NA 1.232 hours 1compartment NA NA Human Human -DTXSID1046687 Css NA 0.111 mg/L 3compartmentss NA 50% Human Human -DTXSID1046687 Css NA 0.8925 mg/L 3compartmentss NA 95% Human Human -DTXSID1046687 Css NA 0.0737 mg/L PBTK NA 50% Human Human -DTXSID1046687 Css NA 0.5573 mg/L PBTK NA 95% Human Human -DTXSID1046687 Clint NA 35.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046687 Fup NA 0.1485 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046687 Vd NA 0.6625 L/kg 1compartment NA NA Rat Human +DTXSID1046687 TK.Half.Life NA 6.836 hours 1compartment NA NA Human Human +DTXSID1046687 Css NA 0.6223 mg/L 3compartmentss NA 50% Human Human +DTXSID1046687 Css NA 4.18 mg/L 3compartmentss NA 95% Human Human +DTXSID1046687 Css NA 0.4234 mg/L PBTK NA 50% Human Human +DTXSID1046687 Css NA 2.645 mg/L PBTK NA 95% Human Human +DTXSID1046687 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046687 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046687 Vd NA 1.036 L/kg 1compartment NA NA Rat Human DTXSID1046687 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046687 TK.Half.Life NA 0.5488 hours 1compartment NA NA Rat Human -DTXSID1046687 Css NA 0.06319 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046687 Css NA 0.3976 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046687 Css NA 0.03977 mg/L PBTK NA 50% Rat Human -DTXSID1046687 Css NA 0.2349 mg/L PBTK NA 95% Rat Human -DTXSID1046689 Clint NA 77.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046689 Fup NA 0.1851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046689 Vd NA 1.094 L/kg 1compartment NA NA Human Human +DTXSID1046687 TK.Half.Life NA 2.801 hours 1compartment NA NA Rat Human +DTXSID1046687 Css NA 0.07626 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046687 Css NA 0.3701 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046687 Css NA 0.05098 mg/L PBTK NA 50% Rat Human +DTXSID1046687 Css NA 0.2258 mg/L PBTK NA 95% Rat Human +DTXSID1046689 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046689 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046689 Vd NA 2.062 L/kg 1compartment NA NA Human Human DTXSID1046689 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046689 TK.Half.Life NA 1.103 hours 1compartment NA NA Human Human -DTXSID1046689 Css NA 0.03239 mg/L 3compartmentss NA 50% Human Human -DTXSID1046689 Css NA 0.2458 mg/L 3compartmentss NA 95% Human Human -DTXSID1046689 Css NA 0.02368 mg/L PBTK NA 50% Human Human -DTXSID1046689 Css NA 0.1659 mg/L PBTK NA 95% Human Human -DTXSID1046689 Clint NA 77.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046689 Fup NA 0.1851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046689 Vd NA 1.076 L/kg 1compartment NA NA Rat Human +DTXSID1046689 TK.Half.Life NA 3.349 hours 1compartment NA NA Human Human +DTXSID1046689 Css NA 0.1057 mg/L 3compartmentss NA 50% Human Human +DTXSID1046689 Css NA 0.8631 mg/L 3compartmentss NA 95% Human Human +DTXSID1046689 Css NA 0.102 mg/L PBTK NA 50% Human Human +DTXSID1046689 Css NA 0.6459 mg/L PBTK NA 95% Human Human +DTXSID1046689 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046689 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046689 Vd NA 2.06 L/kg 1compartment NA NA Rat Human DTXSID1046689 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046689 TK.Half.Life NA 0.5403 hours 1compartment NA NA Rat Human -DTXSID1046689 Css NA 0.01792 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046689 Css NA 0.1111 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046689 Css NA 0.01259 mg/L PBTK NA 50% Rat Human -DTXSID1046689 Css NA 0.07228 mg/L PBTK NA 95% Rat Human -DTXSID1046710 Clint NA 26.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046710 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046710 Vd NA 1.967 L/kg 1compartment NA NA Human Human -DTXSID1046710 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046710 TK.Half.Life NA 1.122 hours 1compartment NA NA Human Human -DTXSID1046710 Css NA 0.01628 mg/L 3compartmentss NA 50% Human Human -DTXSID1046710 Css NA 0.2172 mg/L 3compartmentss NA 95% Human Human -DTXSID1046710 Css NA 0.01638 mg/L PBTK NA 50% Human Human -DTXSID1046710 Css NA 0.1849 mg/L PBTK NA 95% Human Human -DTXSID1046710 Clint NA 26.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046710 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046710 Vd NA 2.01 L/kg 1compartment NA NA Rat Human +DTXSID1046689 TK.Half.Life NA 1.862 hours 1compartment NA NA Rat Human +DTXSID1046689 Css NA 0.01192 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046689 Css NA 0.08063 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046689 Css NA 0.01183 mg/L PBTK NA 50% Rat Human +DTXSID1046689 Css NA 0.05712 mg/L PBTK NA 95% Rat Human +DTXSID1046710 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046710 Fup 0.733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046710 Vd NA 1.483 L/kg 1compartment NA NA Human Human +DTXSID1046710 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1046710 TK.Half.Life NA 13.09 hours 1compartment NA NA Human Human +DTXSID1046710 Css NA 0.889 mg/L 3compartmentss NA 50% Human Human +DTXSID1046710 Css NA 6.299 mg/L 3compartmentss NA 95% Human Human +DTXSID1046710 Css NA 0.8332 mg/L PBTK NA 50% Human Human +DTXSID1046710 Css NA 4.17 mg/L PBTK NA 95% Human Human +DTXSID1046710 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046710 Fup 0.733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046710 Vd NA 1.515 L/kg 1compartment NA NA Rat Human DTXSID1046710 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046710 TK.Half.Life NA 0.551 hours 1compartment NA NA Rat Human -DTXSID1046710 Css NA 0.008112 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046710 Css NA 0.08703 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046710 Css NA 0.008204 mg/L PBTK NA 50% Rat Human -DTXSID1046710 Css NA 0.07064 mg/L PBTK NA 95% Rat Human -DTXSID1046712 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046712 Fup NA 0.599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046712 Vd NA 0.382 L/kg 1compartment NA NA Human Human +DTXSID1046710 TK.Half.Life NA 4.557 hours 1compartment NA NA Rat Human +DTXSID1046710 Css NA 0.0526 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046710 Css NA 0.3589 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046710 Css NA 0.04988 mg/L PBTK NA 50% Rat Human +DTXSID1046710 Css NA 0.2311 mg/L PBTK NA 95% Rat Human +DTXSID1046712 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046712 Fup 0.463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046712 Vd NA 0.3427 L/kg 1compartment NA NA Human Human DTXSID1046712 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046712 TK.Half.Life NA 4.126 hours 1compartment NA NA Human Human -DTXSID1046712 Css NA 1.396 mg/L 3compartmentss NA 50% Human Human -DTXSID1046712 Css NA 8.998 mg/L 3compartmentss NA 95% Human Human -DTXSID1046712 Css NA 0.9826 mg/L PBTK NA 50% Human Human -DTXSID1046712 Css NA 5.459 mg/L PBTK NA 95% Human Human -DTXSID1046712 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046712 Fup NA 0.599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046712 Vd NA 0.3997 L/kg 1compartment NA NA Rat Human +DTXSID1046712 TK.Half.Life NA 4.787 hours 1compartment NA NA Human Human +DTXSID1046712 Css NA 0.9166 mg/L 3compartmentss NA 50% Human Human +DTXSID1046712 Css NA 4.566 mg/L 3compartmentss NA 95% Human Human +DTXSID1046712 Css NA 0.6276 mg/L PBTK NA 50% Human Human +DTXSID1046712 Css NA 2.786 mg/L PBTK NA 95% Human Human +DTXSID1046712 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046712 Fup 0.463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046712 Vd NA 0.3567 L/kg 1compartment NA NA Rat Human DTXSID1046712 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046712 TK.Half.Life NA 1.471 hours 1compartment NA NA Rat Human -DTXSID1046712 Css NA 0.3742 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046712 Css NA 2.132 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046712 Css NA 0.2504 mg/L PBTK NA 50% Rat Human -DTXSID1046712 Css NA 1.208 mg/L PBTK NA 95% Rat Human -DTXSID1046714 Clint NA 5.592 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1046712 TK.Half.Life NA 1.698 hours 1compartment NA NA Rat Human +DTXSID1046712 Css NA 0.004988 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046712 Css NA 0.02423 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046712 Css NA 0.003257 mg/L PBTK NA 50% Rat Human +DTXSID1046712 Css NA 0.01419 mg/L PBTK NA 95% Rat Human +DTXSID1046714 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1046714 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1046714 Vd NA 0.5301 L/kg 1compartment NA NA Human Human DTXSID1046714 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046714 TK.Half.Life NA 0.7515 hours 1compartment NA NA Human Human -DTXSID1046714 Css NA 0.1192 mg/L 3compartmentss NA 50% Human Human -DTXSID1046714 Css NA 0.9933 mg/L 3compartmentss NA 95% Human Human -DTXSID1046714 Css NA 0.08824 mg/L PBTK NA 50% Human Human -DTXSID1046714 Css NA 0.6328 mg/L PBTK NA 95% Human Human -DTXSID1046714 Clint NA 5.592 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1046714 TK.Half.Life NA 4.706 hours 1compartment NA NA Human Human +DTXSID1046714 Css NA 1.111 mg/L 3compartmentss NA 50% Human Human +DTXSID1046714 Css NA 6.574 mg/L 3compartmentss NA 95% Human Human +DTXSID1046714 Css NA 0.8392 mg/L PBTK NA 50% Human Human +DTXSID1046714 Css NA 4.155 mg/L PBTK NA 95% Human Human +DTXSID1046714 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1046714 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1046714 Vd NA 0.5492 L/kg 1compartment NA NA Rat Human DTXSID1046714 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046714 TK.Half.Life NA 0.4021 hours 1compartment NA NA Rat Human -DTXSID1046714 Css NA 0.05472 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046714 Css NA 0.4011 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046714 Css NA 0.03991 mg/L PBTK NA 50% Rat Human -DTXSID1046714 Css NA 0.238 mg/L PBTK NA 95% Rat Human -DTXSID1046716 Clint NA 2.603 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046716 Fup NA 0.0094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046716 Vd NA 0.2329 L/kg 1compartment NA NA Human Human -DTXSID1046716 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1046716 TK.Half.Life NA 29.62 hours 1compartment NA NA Human Human -DTXSID1046716 Css NA 23.22 mg/L 3compartmentss NA 50% Human Human -DTXSID1046716 Css NA 173.7 mg/L 3compartmentss NA 95% Human Human -DTXSID1046716 Css NA 13.76 mg/L PBTK NA 50% Human Human -DTXSID1046716 Css NA 102.8 mg/L PBTK NA 95% Human Human -DTXSID1046716 Clint NA 2.603 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046716 Fup NA 0.0094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046716 Vd NA 0.2185 L/kg 1compartment NA NA Rat Human -DTXSID1046716 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1046716 TK.Half.Life NA 16.27 hours 1compartment NA NA Rat Human -DTXSID1046716 Css NA 11.45 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046716 Css NA 72.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046716 Css NA 6.315 mg/L PBTK NA 50% Rat Human -DTXSID1046716 Css NA 39.3 mg/L PBTK NA 95% Rat Human -DTXSID1046760 Clint NA 20.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046760 Fup NA 0.3378 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046760 Vd NA 2.205 L/kg 1compartment NA NA Human Human +DTXSID1046714 TK.Half.Life NA 1.615 hours 1compartment NA NA Rat Human +DTXSID1046714 Css NA 0.06397 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046714 Css NA 0.3698 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046714 Css NA 0.04814 mg/L PBTK NA 50% Rat Human +DTXSID1046714 Css NA 0.2224 mg/L PBTK NA 95% Rat Human +DTXSID1046716 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046716 Fup 0.0327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046716 Vd NA 0.2577 L/kg 1compartment NA NA Human Human +DTXSID1046716 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046716 TK.Half.Life NA 4.677 hours 1compartment NA NA Human Human +DTXSID1046716 Css NA 3.127 mg/L 3compartmentss NA 50% Human Human +DTXSID1046716 Css NA 25.59 mg/L 3compartmentss NA 95% Human Human +DTXSID1046716 Css NA 1.874 mg/L PBTK NA 50% Human Human +DTXSID1046716 Css NA 15.02 mg/L PBTK NA 95% Human Human +DTXSID1046716 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046716 Fup 0.0327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046716 Vd NA 0.2491 L/kg 1compartment NA NA Rat Human +DTXSID1046716 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1046716 TK.Half.Life NA 2.849 hours 1compartment NA NA Rat Human +DTXSID1046716 Css NA 0.3935 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046716 Css NA 2.416 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046716 Css NA 0.2294 mg/L PBTK NA 50% Rat Human +DTXSID1046716 Css NA 1.365 mg/L PBTK NA 95% Rat Human +DTXSID1046760 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046760 Fup 0.564 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046760 Vd NA 2.244 L/kg 1compartment NA NA Human Human DTXSID1046760 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046760 TK.Half.Life NA 2.352 hours 1compartment NA NA Human Human -DTXSID1046760 Css NA 0.04964 mg/L 3compartmentss NA 50% Human Human -DTXSID1046760 Css NA 0.4013 mg/L 3compartmentss NA 95% Human Human -DTXSID1046760 Css NA 0.0467 mg/L PBTK NA 50% Human Human -DTXSID1046760 Css NA 0.3185 mg/L PBTK NA 95% Human Human -DTXSID1046760 Clint NA 20.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046760 Fup NA 0.3378 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046760 Vd NA 2.207 L/kg 1compartment NA NA Rat Human +DTXSID1046760 TK.Half.Life NA 3.206 hours 1compartment NA NA Human Human +DTXSID1046760 Css NA 0.09189 mg/L 3compartmentss NA 50% Human Human +DTXSID1046760 Css NA 0.9698 mg/L 3compartmentss NA 95% Human Human +DTXSID1046760 Css NA 0.0931 mg/L PBTK NA 50% Human Human +DTXSID1046760 Css NA 0.7165 mg/L PBTK NA 95% Human Human +DTXSID1046760 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046760 Fup 0.564 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046760 Vd NA 2.27 L/kg 1compartment NA NA Rat Human DTXSID1046760 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046760 TK.Half.Life NA 1.27 hours 1compartment NA NA Rat Human -DTXSID1046760 Css NA 0.02603 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046760 Css NA 0.1668 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046760 Css NA 0.02416 mg/L PBTK NA 50% Rat Human -DTXSID1046760 Css NA 0.1271 mg/L PBTK NA 95% Rat Human -DTXSID1046764 Clint NA 8.139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046764 Fup NA 0.3704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046764 Vd NA 3.005 L/kg 1compartment NA NA Human Human +DTXSID1046760 TK.Half.Life NA 1.81 hours 1compartment NA NA Rat Human +DTXSID1046760 Css NA 0.0102 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046760 Css NA 0.09746 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046760 Css NA 0.01068 mg/L PBTK NA 50% Rat Human +DTXSID1046760 Css NA 0.06628 mg/L PBTK NA 95% Rat Human +DTXSID1046764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046764 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046764 Vd NA 3.325 L/kg 1compartment NA NA Human Human DTXSID1046764 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046764 TK.Half.Life NA 4.652 hours 1compartment NA NA Human Human -DTXSID1046764 Css NA 0.09042 mg/L 3compartmentss NA 50% Human Human -DTXSID1046764 Css NA 0.696 mg/L 3compartmentss NA 95% Human Human -DTXSID1046764 Css NA 0.1005 mg/L PBTK NA 50% Human Human -DTXSID1046764 Css NA 0.5959 mg/L PBTK NA 95% Human Human -DTXSID1046764 Clint NA 8.139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046764 Fup NA 0.3704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046764 Vd NA 3.046 L/kg 1compartment NA NA Rat Human +DTXSID1046764 TK.Half.Life NA 2.912 hours 1compartment NA NA Human Human +DTXSID1046764 Css NA 0.03138 mg/L 3compartmentss NA 50% Human Human +DTXSID1046764 Css NA 0.2944 mg/L 3compartmentss NA 95% Human Human +DTXSID1046764 Css NA 0.03676 mg/L PBTK NA 50% Human Human +DTXSID1046764 Css NA 0.2759 mg/L PBTK NA 95% Human Human +DTXSID1046764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046764 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046764 Vd NA 3.375 L/kg 1compartment NA NA Rat Human DTXSID1046764 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046764 TK.Half.Life NA 2.738 hours 1compartment NA NA Rat Human -DTXSID1046764 Css NA 0.04526 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046764 Css NA 0.2766 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046764 Css NA 0.05012 mg/L PBTK NA 50% Rat Human -DTXSID1046764 Css NA 0.2257 mg/L PBTK NA 95% Rat Human -DTXSID1046766 Clint NA 2.236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046766 Fup NA 0.3041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046766 Vd NA 3.602 L/kg 1compartment NA NA Human Human -DTXSID1046766 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1046766 TK.Half.Life NA 18.39 hours 1compartment NA NA Human Human -DTXSID1046766 Css NA 0.3739 mg/L 3compartmentss NA 50% Human Human -DTXSID1046766 Css NA 2.044 mg/L 3compartmentss NA 95% Human Human -DTXSID1046766 Css NA 0.417 mg/L PBTK NA 50% Human Human -DTXSID1046766 Css NA 1.767 mg/L PBTK NA 95% Human Human -DTXSID1046766 Clint NA 2.236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046766 Fup NA 0.3041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046766 Vd NA 3.509 L/kg 1compartment NA NA Rat Human -DTXSID1046766 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1046766 TK.Half.Life NA 8.784 hours 1compartment NA NA Rat Human -DTXSID1046766 Css NA 0.1682 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046766 Css NA 0.7526 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046766 Css NA 0.1871 mg/L PBTK NA 50% Rat Human -DTXSID1046766 Css NA 0.5909 mg/L PBTK NA 95% Rat Human +DTXSID1046764 TK.Half.Life NA 1.62 hours 1compartment NA NA Rat Human +DTXSID1046764 Css NA 0.003852 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046764 Css NA 0.0273 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046764 Css NA 0.004691 mg/L PBTK NA 50% Rat Human +DTXSID1046764 Css NA 0.02546 mg/L PBTK NA 95% Rat Human +DTXSID1046766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046766 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046766 Vd NA 3.517 L/kg 1compartment NA NA Human Human +DTXSID1046766 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1046766 TK.Half.Life NA 3.792 hours 1compartment NA NA Human Human +DTXSID1046766 Css NA 0.04671 mg/L 3compartmentss NA 50% Human Human +DTXSID1046766 Css NA 0.4005 mg/L 3compartmentss NA 95% Human Human +DTXSID1046766 Css NA 0.05056 mg/L PBTK NA 50% Human Human +DTXSID1046766 Css NA 0.3626 mg/L PBTK NA 95% Human Human +DTXSID1046766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046766 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046766 Vd NA 3.426 L/kg 1compartment NA NA Rat Human +DTXSID1046766 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1046766 TK.Half.Life NA 1.897 hours 1compartment NA NA Rat Human +DTXSID1046766 Css NA 0.00575 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046766 Css NA 0.03863 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046766 Css NA 0.006465 mg/L PBTK NA 50% Rat Human +DTXSID1046766 Css NA 0.03416 mg/L PBTK NA 95% Rat Human DTXSID1046768 Clint NA 0.8242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046768 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046768 Vd NA 0.2259 L/kg 1compartment NA NA Human Human -DTXSID1046768 Days.Css NA 31 Days PBTK NA NA Human Human -DTXSID1046768 TK.Half.Life NA 139.7 hours 1compartment NA NA Human Human -DTXSID1046768 Css NA 109.8 mg/L 3compartmentss NA 50% Human Human -DTXSID1046768 Css NA 679.8 mg/L 3compartmentss NA 95% Human Human -DTXSID1046768 Css NA 64.32 mg/L PBTK NA 50% Human Human -DTXSID1046768 Css NA 393.5 mg/L PBTK NA 95% Human Human +DTXSID1046768 Vd NA 0.1812 L/kg 1compartment NA NA Human Human +DTXSID1046768 Days.Css NA 25 Days PBTK NA NA Human Human +DTXSID1046768 TK.Half.Life NA 114.9 hours 1compartment NA NA Human Human +DTXSID1046768 Css NA 93.64 mg/L 3compartmentss NA 50% Human Human +DTXSID1046768 Css NA 601.5 mg/L 3compartmentss NA 95% Human Human +DTXSID1046768 Css NA 54.88 mg/L PBTK NA 50% Human Human +DTXSID1046768 Css NA 346.6 mg/L PBTK NA 95% Human Human DTXSID1046768 Clint NA 0.8242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046768 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046768 Vd NA 0.2102 L/kg 1compartment NA NA Rat Human -DTXSID1046768 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID1046768 TK.Half.Life NA 63.53 hours 1compartment NA NA Rat Human -DTXSID1046768 Css NA 44.37 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046768 Css NA 243.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046768 Css NA 24.34 mg/L PBTK NA 50% Rat Human -DTXSID1046768 Css NA 131.7 mg/L PBTK NA 95% Rat Human -DTXSID1046841 Clint NA 20.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046841 Fup NA 0.101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046841 Vd NA 2.795 L/kg 1compartment NA NA Human Human -DTXSID1046841 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046841 TK.Half.Life NA 8.398 hours 1compartment NA NA Human Human -DTXSID1046841 Css NA 0.3027 mg/L 3compartmentss NA 50% Human Human -DTXSID1046841 Css NA 2.161 mg/L 3compartmentss NA 95% Human Human -DTXSID1046841 Css NA 0.2304 mg/L PBTK NA 50% Human Human -DTXSID1046841 Css NA 1.534 mg/L PBTK NA 95% Human Human -DTXSID1046841 Clint NA 20.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046841 Fup NA 0.101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046841 Vd NA 2.338 L/kg 1compartment NA NA Rat Human +DTXSID1046768 Vd NA 0.1769 L/kg 1compartment NA NA Rat Human +DTXSID1046768 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID1046768 TK.Half.Life NA 54.45 hours 1compartment NA NA Rat Human +DTXSID1046768 Css NA 2.596 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046768 Css NA 20.99 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046768 Css NA 1.426 mg/L PBTK NA 50% Rat Human +DTXSID1046768 Css NA 11.67 mg/L PBTK NA 95% Rat Human +DTXSID1046841 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046841 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046841 Vd NA 2.472 L/kg 1compartment NA NA Human Human +DTXSID1046841 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1046841 TK.Half.Life NA 15.59 hours 1compartment NA NA Human Human +DTXSID1046841 Css NA 0.7232 mg/L 3compartmentss NA 50% Human Human +DTXSID1046841 Css NA 4.9 mg/L 3compartmentss NA 95% Human Human +DTXSID1046841 Css NA 0.5554 mg/L PBTK NA 50% Human Human +DTXSID1046841 Css NA 3.4 mg/L PBTK NA 95% Human Human +DTXSID1046841 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046841 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046841 Vd NA 2.151 L/kg 1compartment NA NA Rat Human DTXSID1046841 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046841 TK.Half.Life NA 2.941 hours 1compartment NA NA Rat Human -DTXSID1046841 Css NA 0.1673 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046841 Css NA 0.9215 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046841 Css NA 0.1224 mg/L PBTK NA 50% Rat Human -DTXSID1046841 Css NA 0.6132 mg/L PBTK NA 95% Rat Human -DTXSID1046843 Clint NA 13.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046843 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046843 Vd NA 3.02 L/kg 1compartment NA NA Human Human -DTXSID1046843 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID1046843 TK.Half.Life NA 117.9 hours 1compartment NA NA Human Human -DTXSID1046843 Css NA 4.99 mg/L 3compartmentss NA 50% Human Human -DTXSID1046843 Css NA 30.87 mg/L 3compartmentss NA 95% Human Human -DTXSID1046843 Css NA 3.424 mg/L PBTK NA 50% Human Human -DTXSID1046843 Css NA 20.74 mg/L PBTK NA 95% Human Human -DTXSID1046843 Clint NA 13.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046843 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046843 Vd NA 2.263 L/kg 1compartment NA NA Rat Human -DTXSID1046843 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID1046843 TK.Half.Life NA 18.02 hours 1compartment NA NA Rat Human -DTXSID1046843 Css NA 2.822 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046843 Css NA 14.97 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046843 Css NA 1.85 mg/L PBTK NA 50% Rat Human -DTXSID1046843 Css NA 9.468 mg/L PBTK NA 95% Rat Human -DTXSID1046845 Clint NA 5.584 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046845 Fup NA 0.1583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046845 Vd NA 1.595 L/kg 1compartment NA NA Human Human +DTXSID1046841 TK.Half.Life NA 6.521 hours 1compartment NA NA Rat Human +DTXSID1046841 Css NA 0.08814 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046841 Css NA 0.4557 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046841 Css NA 0.06766 mg/L PBTK NA 50% Rat Human +DTXSID1046841 Css NA 0.2989 mg/L PBTK NA 95% Rat Human +DTXSID1046843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046843 Fup 0.0173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046843 Vd NA 3.117 L/kg 1compartment NA NA Human Human +DTXSID1046843 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID1046843 TK.Half.Life NA 91.05 hours 1compartment NA NA Human Human +DTXSID1046843 Css NA 3.443 mg/L 3compartmentss NA 50% Human Human +DTXSID1046843 Css NA 21.39 mg/L 3compartmentss NA 95% Human Human +DTXSID1046843 Css NA 2.383 mg/L PBTK NA 50% Human Human +DTXSID1046843 Css NA 14.46 mg/L PBTK NA 95% Human Human +DTXSID1046843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046843 Fup 0.0173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046843 Vd NA 2.336 L/kg 1compartment NA NA Rat Human +DTXSID1046843 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID1046843 TK.Half.Life NA 12.33 hours 1compartment NA NA Rat Human +DTXSID1046843 Css NA 0.4478 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046843 Css NA 2.264 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046843 Css NA 0.3077 mg/L PBTK NA 50% Rat Human +DTXSID1046843 Css NA 1.538 mg/L PBTK NA 95% Rat Human +DTXSID1046845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046845 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046845 Vd NA 5.98 L/kg 1compartment NA NA Human Human DTXSID1046845 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046845 TK.Half.Life NA 8.3 hours 1compartment NA NA Human Human -DTXSID1046845 Css NA 0.6026 mg/L 3compartmentss NA 50% Human Human -DTXSID1046845 Css NA 3.762 mg/L 3compartmentss NA 95% Human Human -DTXSID1046845 Css NA 0.4342 mg/L PBTK NA 50% Human Human -DTXSID1046845 Css NA 2.478 mg/L PBTK NA 95% Human Human -DTXSID1046845 Clint NA 5.584 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046845 Fup NA 0.1583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046845 Vd NA 1.325 L/kg 1compartment NA NA Rat Human +DTXSID1046845 TK.Half.Life NA 3.431 hours 1compartment NA NA Human Human +DTXSID1046845 Css NA 0.01396 mg/L 3compartmentss NA 50% Human Human +DTXSID1046845 Css NA 0.1348 mg/L 3compartmentss NA 95% Human Human +DTXSID1046845 Css NA 0.0242 mg/L PBTK NA 50% Human Human +DTXSID1046845 Css NA 0.1712 mg/L PBTK NA 95% Human Human +DTXSID1046845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046845 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046845 Vd NA 6.065 L/kg 1compartment NA NA Rat Human DTXSID1046845 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046845 TK.Half.Life NA 3.571 hours 1compartment NA NA Rat Human -DTXSID1046845 Css NA 0.3133 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046845 Css NA 1.403 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046845 Css NA 0.2134 mg/L PBTK NA 50% Rat Human -DTXSID1046845 Css NA 0.8487 mg/L PBTK NA 95% Rat Human -DTXSID1046847 Clint NA 17.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046847 Fup NA 0.0503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046847 Vd NA 1.599 L/kg 1compartment NA NA Human Human +DTXSID1046845 TK.Half.Life NA 1.863 hours 1compartment NA NA Rat Human +DTXSID1046845 Css NA 0.001626 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046845 Css NA 0.01372 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046845 Css NA 0.003107 mg/L PBTK NA 50% Rat Human +DTXSID1046845 Css NA 0.0172 mg/L PBTK NA 95% Rat Human +DTXSID1046847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046847 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046847 Vd NA 3.741 L/kg 1compartment NA NA Human Human DTXSID1046847 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046847 TK.Half.Life NA 6.102 hours 1compartment NA NA Human Human -DTXSID1046847 Css NA 0.478 mg/L 3compartmentss NA 50% Human Human -DTXSID1046847 Css NA 4.289 mg/L 3compartmentss NA 95% Human Human -DTXSID1046847 Css NA 0.345 mg/L PBTK NA 50% Human Human -DTXSID1046847 Css NA 2.802 mg/L PBTK NA 95% Human Human -DTXSID1046847 Clint NA 17.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046847 Fup NA 0.0503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046847 Vd NA 1.534 L/kg 1compartment NA NA Rat Human +DTXSID1046847 TK.Half.Life NA 4.587 hours 1compartment NA NA Human Human +DTXSID1046847 Css NA 0.05746 mg/L 3compartmentss NA 50% Human Human +DTXSID1046847 Css NA 0.4776 mg/L 3compartmentss NA 95% Human Human +DTXSID1046847 Css NA 0.06249 mg/L PBTK NA 50% Human Human +DTXSID1046847 Css NA 0.4415 mg/L PBTK NA 95% Human Human +DTXSID1046847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046847 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046847 Vd NA 3.654 L/kg 1compartment NA NA Rat Human DTXSID1046847 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046847 TK.Half.Life NA 3.591 hours 1compartment NA NA Rat Human -DTXSID1046847 Css NA 0.2676 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046847 Css NA 1.919 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046847 Css NA 0.1811 mg/L PBTK NA 50% Rat Human -DTXSID1046847 Css NA 1.159 mg/L PBTK NA 95% Rat Human -DTXSID1046849 Clint NA 32.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046849 Fup NA 0.3248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046849 Vd NA 1.056 L/kg 1compartment NA NA Human Human +DTXSID1046847 TK.Half.Life NA 2.345 hours 1compartment NA NA Rat Human +DTXSID1046847 Css NA 0.007196 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046847 Css NA 0.04488 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046847 Css NA 0.008133 mg/L PBTK NA 50% Rat Human +DTXSID1046847 Css NA 0.04213 mg/L PBTK NA 95% Rat Human +DTXSID1046849 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046849 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046849 Vd NA 0.9658 L/kg 1compartment NA NA Human Human DTXSID1046849 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046849 TK.Half.Life NA 1.142 hours 1compartment NA NA Human Human -DTXSID1046849 Css NA 0.04456 mg/L 3compartmentss NA 50% Human Human -DTXSID1046849 Css NA 0.3478 mg/L 3compartmentss NA 95% Human Human -DTXSID1046849 Css NA 0.03382 mg/L PBTK NA 50% Human Human -DTXSID1046849 Css NA 0.2382 mg/L PBTK NA 95% Human Human -DTXSID1046849 Clint NA 32.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046849 Fup NA 0.3248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046849 Vd NA 0.9123 L/kg 1compartment NA NA Rat Human +DTXSID1046849 TK.Half.Life NA 2.862 hours 1compartment NA NA Human Human +DTXSID1046849 Css NA 0.2714 mg/L 3compartmentss NA 50% Human Human +DTXSID1046849 Css NA 1.598 mg/L 3compartmentss NA 95% Human Human +DTXSID1046849 Css NA 0.1964 mg/L PBTK NA 50% Human Human +DTXSID1046849 Css NA 1.076 mg/L PBTK NA 95% Human Human +DTXSID1046849 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046849 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046849 Vd NA 0.8259 L/kg 1compartment NA NA Rat Human DTXSID1046849 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046849 TK.Half.Life NA 0.4916 hours 1compartment NA NA Rat Human -DTXSID1046849 Css NA 0.0246 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046849 Css NA 0.1436 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046849 Css NA 0.01774 mg/L PBTK NA 50% Rat Human -DTXSID1046849 Css NA 0.09493 mg/L PBTK NA 95% Rat Human -DTXSID1046891 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046891 Fup NA 0.3069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046891 Vd NA 0.4051 L/kg 1compartment NA NA Human Human +DTXSID1046849 TK.Half.Life NA 1.358 hours 1compartment NA NA Rat Human +DTXSID1046849 Css NA 0.03198 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046849 Css NA 0.1409 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046849 Css NA 0.02298 mg/L PBTK NA 50% Rat Human +DTXSID1046849 Css NA 0.09094 mg/L PBTK NA 95% Rat Human +DTXSID1046891 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046891 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046891 Vd NA 0.4974 L/kg 1compartment NA NA Human Human DTXSID1046891 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046891 TK.Half.Life NA 8.55 hours 1compartment NA NA Human Human -DTXSID1046891 Css NA 2.552 mg/L 3compartmentss NA 50% Human Human -DTXSID1046891 Css NA 9.921 mg/L 3compartmentss NA 95% Human Human -DTXSID1046891 Css NA 1.732 mg/L PBTK NA 50% Human Human -DTXSID1046891 Css NA 6.14 mg/L PBTK NA 95% Human Human -DTXSID1046891 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046891 Fup NA 0.3069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046891 Vd NA 0.4078 L/kg 1compartment NA NA Rat Human +DTXSID1046891 TK.Half.Life NA 0.9595 hours 1compartment NA NA Human Human +DTXSID1046891 Css NA 0.0749 mg/L 3compartmentss NA 50% Human Human +DTXSID1046891 Css NA 0.5998 mg/L 3compartmentss NA 95% Human Human +DTXSID1046891 Css NA 0.05508 mg/L PBTK NA 50% Human Human +DTXSID1046891 Css NA 0.3902 mg/L PBTK NA 95% Human Human +DTXSID1046891 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046891 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046891 Vd NA 0.5119 L/kg 1compartment NA NA Rat Human DTXSID1046891 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046891 TK.Half.Life NA 2.931 hours 1compartment NA NA Rat Human -DTXSID1046891 Css NA 0.709 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046891 Css NA 2.338 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046891 Css NA 0.4553 mg/L PBTK NA 50% Rat Human -DTXSID1046891 Css NA 1.344 mg/L PBTK NA 95% Rat Human +DTXSID1046891 TK.Half.Life NA 0.5488 hours 1compartment NA NA Rat Human +DTXSID1046891 Css NA 0.0007034 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046891 Css NA 0.004781 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046891 Css NA 0.0004967 mg/L PBTK NA 50% Rat Human +DTXSID1046891 Css NA 0.002992 mg/L PBTK NA 95% Rat Human DTXSID1046895 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046895 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046895 Vd NA 0.8014 L/kg 1compartment NA NA Human Human +DTXSID1046895 Vd NA 0.7712 L/kg 1compartment NA NA Human Human DTXSID1046895 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046895 TK.Half.Life NA 5.188 hours 1compartment NA NA Human Human -DTXSID1046895 Css NA 0.8236 mg/L 3compartmentss NA 50% Human Human -DTXSID1046895 Css NA 5.552 mg/L 3compartmentss NA 95% Human Human -DTXSID1046895 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID1046895 Css NA 3.599 mg/L PBTK NA 95% Human Human +DTXSID1046895 TK.Half.Life NA 4.99 hours 1compartment NA NA Human Human +DTXSID1046895 Css NA 0.7006 mg/L 3compartmentss NA 50% Human Human +DTXSID1046895 Css NA 5.044 mg/L 3compartmentss NA 95% Human Human +DTXSID1046895 Css NA 0.5894 mg/L PBTK NA 50% Human Human +DTXSID1046895 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID1046895 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046895 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046895 Vd NA 0.8376 L/kg 1compartment NA NA Rat Human +DTXSID1046895 Vd NA 0.8116 L/kg 1compartment NA NA Rat Human DTXSID1046895 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046895 TK.Half.Life NA 1.847 hours 1compartment NA NA Rat Human -DTXSID1046895 Css NA 0.207 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046895 Css NA 1.327 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046895 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID1046895 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID1046895 TK.Half.Life NA 1.79 hours 1compartment NA NA Rat Human +DTXSID1046895 Css NA 0.01284 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046895 Css NA 0.09988 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046895 Css NA 0.0105 mg/L PBTK NA 50% Rat Human +DTXSID1046895 Css NA 0.0655 mg/L PBTK NA 95% Rat Human DTXSID1046926 Clint NA 1354 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1046926 Fup NA 0.1229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046926 Vd NA 0.6139 L/kg 1compartment NA NA Human Human +DTXSID1046926 Vd NA 0.2085 L/kg 1compartment NA NA Human Human DTXSID1046926 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046926 TK.Half.Life NA 0.5441 hours 1compartment NA NA Human Human -DTXSID1046926 Css NA 0.003748 mg/L 3compartmentss NA 50% Human Human -DTXSID1046926 Css NA 0.03312 mg/L 3compartmentss NA 95% Human Human -DTXSID1046926 Css NA 0.002403 mg/L PBTK NA 50% Human Human -DTXSID1046926 Css NA 0.02041 mg/L PBTK NA 95% Human Human +DTXSID1046926 TK.Half.Life NA 0.1986 hours 1compartment NA NA Human Human +DTXSID1046926 Css NA 0.0008808 mg/L 3compartmentss NA 50% Human Human +DTXSID1046926 Css NA 0.01983 mg/L 3compartmentss NA 95% Human Human +DTXSID1046926 Css NA 0.0005312 mg/L PBTK NA 50% Human Human +DTXSID1046926 Css NA 0.01152 mg/L PBTK NA 95% Human Human DTXSID1046926 Clint NA 1354 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1046926 Fup NA 0.1229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046926 Vd NA 0.5367 L/kg 1compartment NA NA Rat Human +DTXSID1046926 Vd NA 0.2137 L/kg 1compartment NA NA Rat Human DTXSID1046926 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046926 TK.Half.Life NA 0.2107 hours 1compartment NA NA Rat Human -DTXSID1046926 Css NA 0.002171 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046926 Css NA 0.01492 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046926 Css NA 0.001314 mg/L PBTK NA 50% Rat Human -DTXSID1046926 Css NA 0.008756 mg/L PBTK NA 95% Rat Human +DTXSID1046926 TK.Half.Life NA 0.08983 hours 1compartment NA NA Rat Human +DTXSID1046926 Css NA 2.846e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046926 Css NA 0.0008535 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046926 Css NA 1.638e-05 mg/L PBTK NA 50% Rat Human +DTXSID1046926 Css NA 0.0004861 mg/L PBTK NA 95% Rat Human DTXSID1046970 Clint 47 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1046970 Fup 0.0415 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID1046970 Vd NA 2.755 L/kg 1compartment NA NA Human Human +DTXSID1046970 Vd NA 2.7 L/kg 1compartment NA NA Human Human DTXSID1046970 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046970 TK.Half.Life NA 14.23 hours 1compartment NA NA Human Human -DTXSID1046970 Css NA 0.5486 mg/L 3compartmentss NA 50% Human Human -DTXSID1046970 Css NA 3.422 mg/L 3compartmentss NA 95% Human Human -DTXSID1046970 Css NA 0.3776 mg/L PBTK NA 50% Human Human -DTXSID1046970 Css NA 2.289 mg/L PBTK NA 95% Human Human +DTXSID1046970 TK.Half.Life NA 13.19 hours 1compartment NA NA Human Human +DTXSID1046970 Css NA 0.5018 mg/L 3compartmentss NA 50% Human Human +DTXSID1046970 Css NA 3.164 mg/L 3compartmentss NA 95% Human Human +DTXSID1046970 Css NA 0.3426 mg/L PBTK NA 50% Human Human +DTXSID1046970 Css NA 2.122 mg/L PBTK NA 95% Human Human DTXSID1046970 Clint 47 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1046970 Fup 0.0415 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID1046970 Vd NA 2.063 L/kg 1compartment NA NA Rat Human +DTXSID1046970 Vd NA 2.021 L/kg 1compartment NA NA Rat Human DTXSID1046970 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046970 TK.Half.Life NA 3.121 hours 1compartment NA NA Rat Human -DTXSID1046970 Css NA 0.307 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046970 Css NA 1.655 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046970 Css NA 0.2008 mg/L PBTK NA 50% Rat Human -DTXSID1046970 Css NA 1.047 mg/L PBTK NA 95% Rat Human -DTXSID1046974 Clint NA 15.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046974 Fup NA 0.3638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046974 Vd NA 1.725 L/kg 1compartment NA NA Human Human +DTXSID1046970 TK.Half.Life NA 3.02 hours 1compartment NA NA Rat Human +DTXSID1046970 Css NA 0.06451 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046970 Css NA 0.3643 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046970 Css NA 0.04357 mg/L PBTK NA 50% Rat Human +DTXSID1046970 Css NA 0.2445 mg/L PBTK NA 95% Rat Human +DTXSID1046974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046974 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046974 Vd NA 1.097 L/kg 1compartment NA NA Human Human DTXSID1046974 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046974 TK.Half.Life NA 2.587 hours 1compartment NA NA Human Human -DTXSID1046974 Css NA 0.09628 mg/L 3compartmentss NA 50% Human Human -DTXSID1046974 Css NA 0.6508 mg/L 3compartmentss NA 95% Human Human -DTXSID1046974 Css NA 0.07575 mg/L PBTK NA 50% Human Human -DTXSID1046974 Css NA 0.4597 mg/L PBTK NA 95% Human Human -DTXSID1046974 Clint NA 15.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046974 Fup NA 0.3638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046974 Vd NA 1.39 L/kg 1compartment NA NA Rat Human +DTXSID1046974 TK.Half.Life NA 1.77 hours 1compartment NA NA Human Human +DTXSID1046974 Css NA 0.102 mg/L 3compartmentss NA 50% Human Human +DTXSID1046974 Css NA 0.7273 mg/L 3compartmentss NA 95% Human Human +DTXSID1046974 Css NA 0.07282 mg/L PBTK NA 50% Human Human +DTXSID1046974 Css NA 0.482 mg/L PBTK NA 95% Human Human +DTXSID1046974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046974 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046974 Vd NA 0.8995 L/kg 1compartment NA NA Rat Human DTXSID1046974 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046974 TK.Half.Life NA 0.9898 hours 1compartment NA NA Rat Human -DTXSID1046974 Css NA 0.05156 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046974 Css NA 0.2674 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046974 Css NA 0.03909 mg/L PBTK NA 50% Rat Human -DTXSID1046974 Css NA 0.1823 mg/L PBTK NA 95% Rat Human -DTXSID1046976 Clint NA 2.003 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046976 Fup NA 0.1491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046976 Vd NA 0.7228 L/kg 1compartment NA NA Human Human +DTXSID1046974 TK.Half.Life NA 0.7621 hours 1compartment NA NA Rat Human +DTXSID1046974 Css NA 0.01297 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046974 Css NA 0.06967 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046974 Css NA 0.00917 mg/L PBTK NA 50% Rat Human +DTXSID1046974 Css NA 0.04651 mg/L PBTK NA 95% Rat Human +DTXSID1046976 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046976 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1046976 Vd NA 0.5481 L/kg 1compartment NA NA Human Human DTXSID1046976 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046976 TK.Half.Life NA 7.76 hours 1compartment NA NA Human Human -DTXSID1046976 Css NA 1.484 mg/L 3compartmentss NA 50% Human Human -DTXSID1046976 Css NA 8.413 mg/L 3compartmentss NA 95% Human Human -DTXSID1046976 Css NA 0.9775 mg/L PBTK NA 50% Human Human -DTXSID1046976 Css NA 5.119 mg/L PBTK NA 95% Human Human -DTXSID1046976 Clint NA 2.003 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046976 Fup NA 0.1491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046976 Vd NA 0.6026 L/kg 1compartment NA NA Rat Human +DTXSID1046976 TK.Half.Life NA 0.9216 hours 1compartment NA NA Human Human +DTXSID1046976 Css NA 0.1094 mg/L 3compartmentss NA 50% Human Human +DTXSID1046976 Css NA 0.8102 mg/L 3compartmentss NA 95% Human Human +DTXSID1046976 Css NA 0.07332 mg/L PBTK NA 50% Human Human +DTXSID1046976 Css NA 0.5081 mg/L PBTK NA 95% Human Human +DTXSID1046976 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046976 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1046976 Vd NA 0.4949 L/kg 1compartment NA NA Rat Human DTXSID1046976 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046976 TK.Half.Life NA 3.443 hours 1compartment NA NA Rat Human -DTXSID1046976 Css NA 0.6886 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046976 Css NA 2.854 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046976 Css NA 0.4278 mg/L PBTK NA 50% Rat Human -DTXSID1046976 Css NA 1.621 mg/L PBTK NA 95% Rat Human -DTXSID1046978 Clint NA 6.335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046978 Fup NA 0.9425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1046978 Vd NA 0.6491 L/kg 1compartment NA NA Human Human -DTXSID1046978 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1046978 TK.Half.Life NA 0.6633 hours 1compartment NA NA Human Human -DTXSID1046978 Css NA 0.07426 mg/L 3compartmentss NA 50% Human Human -DTXSID1046978 Css NA 0.5899 mg/L 3compartmentss NA 95% Human Human -DTXSID1046978 Css NA 0.05922 mg/L PBTK NA 50% Human Human -DTXSID1046978 Css NA 0.4076 mg/L PBTK NA 95% Human Human -DTXSID1046978 Clint NA 6.335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046978 Fup NA 0.9425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1046978 Vd NA 0.6798 L/kg 1compartment NA NA Rat Human -DTXSID1046978 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1046978 TK.Half.Life NA 0.3558 hours 1compartment NA NA Rat Human -DTXSID1046978 Css NA 0.0356 mg/L 3compartmentss NA 50% Rat Human -DTXSID1046978 Css NA 0.2399 mg/L 3compartmentss NA 95% Rat Human -DTXSID1046978 Css NA 0.02795 mg/L PBTK NA 50% Rat Human -DTXSID1046978 Css NA 0.1511 mg/L PBTK NA 95% Rat Human -DTXSID1047027 Clint NA 646.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047027 Fup NA 0.0031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047027 Vd NA 41020 L/kg 1compartment NA NA Human Human -DTXSID1047027 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID1047027 TK.Half.Life NA 41930 hours 1compartment NA NA Human Human -DTXSID1047027 Css NA 1.067e-05 mg/L 3compartmentss NA 50% Human Human -DTXSID1047027 Css NA 6.583e-05 mg/L 3compartmentss NA 95% Human Human -DTXSID1047027 Css NA 0.08525 mg/L PBTK NA 50% Human Human -DTXSID1047027 Css NA 0.4698 mg/L PBTK NA 95% Human Human -DTXSID1047027 Clint NA 646.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047027 Fup NA 0.0031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047027 Vd NA 38900 L/kg 1compartment NA NA Rat Human -DTXSID1047027 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID1047027 TK.Half.Life NA 7557 hours 1compartment NA NA Rat Human -DTXSID1047027 Css NA 5.418e-06 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047027 Css NA 2.351e-05 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047027 Css NA 0.04603 mg/L PBTK NA 50% Rat Human -DTXSID1047027 Css NA 0.201 mg/L PBTK NA 95% Rat Human -DTXSID1047029 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047029 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047029 Vd NA 273 L/kg 1compartment NA NA Human Human -DTXSID1047029 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID1047029 TK.Half.Life NA 13080000 hours 1compartment NA NA Human Human -DTXSID1047029 Css NA 100.1 mg/L 3compartmentss NA 50% Human Human -DTXSID1047029 Css NA 256.4 mg/L 3compartmentss NA 95% Human Human -DTXSID1047029 Css NA 3750 mg/L PBTK NA 50% Human Human -DTXSID1047029 Css NA 7999 mg/L PBTK NA 95% Human Human -DTXSID1047029 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047029 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047029 Vd NA 243.1 L/kg 1compartment NA NA Rat Human -DTXSID1047029 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID1047029 TK.Half.Life NA 1022000 hours 1compartment NA NA Rat Human -DTXSID1047029 Css NA 24.37 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047029 Css NA 41.72 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047029 Css NA 1011 mg/L PBTK NA 50% Rat Human -DTXSID1047029 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID1047071 Clint NA 3.534 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047071 Fup NA 0.3716 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047071 Vd NA 1.889 L/kg 1compartment NA NA Human Human +DTXSID1046976 TK.Half.Life NA 0.4584 hours 1compartment NA NA Rat Human +DTXSID1046976 Css NA 0.01416 mg/L 3compartmentss NA 50% Rat Human +DTXSID1046976 Css NA 0.07741 mg/L 3compartmentss NA 95% Rat Human +DTXSID1046976 Css NA 0.009322 mg/L PBTK NA 50% Rat Human +DTXSID1046976 Css NA 0.04842 mg/L PBTK NA 95% Rat Human +DTXSID10469987 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10469987 Fup 0.0246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10469987 Vd NA 1.528 L/kg 1compartment NA NA Human Human +DTXSID10469987 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID10469987 TK.Half.Life NA 37.25 hours 1compartment NA NA Human Human +DTXSID10469987 Css NA 3.926 mg/L 3compartmentss NA 50% Human Human +DTXSID10469987 Css NA 29.69 mg/L 3compartmentss NA 95% Human Human +DTXSID10469987 Css NA 2.479 mg/L PBTK NA 50% Human Human +DTXSID10469987 Css NA 17.77 mg/L PBTK NA 95% Human Human +DTXSID10469987 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10469987 Fup 0.0246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10469987 Vd NA 1.134 L/kg 1compartment NA NA Rat Human +DTXSID10469987 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID10469987 TK.Half.Life NA 13.77 hours 1compartment NA NA Rat Human +DTXSID10469987 Css NA 0.4428 mg/L 3compartmentss NA 50% Rat Human +DTXSID10469987 Css NA 2.721 mg/L 3compartmentss NA 95% Rat Human +DTXSID10469987 Css NA 0.2702 mg/L PBTK NA 50% Rat Human +DTXSID10469987 Css NA 1.572 mg/L PBTK NA 95% Rat Human +DTXSID1047071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047071 Fup 0.283 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047071 Vd NA 1.759 L/kg 1compartment NA NA Human Human DTXSID1047071 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047071 TK.Half.Life NA 6.324 hours 1compartment NA NA Human Human -DTXSID1047071 Css NA 0.294 mg/L 3compartmentss NA 50% Human Human -DTXSID1047071 Css NA 1.688 mg/L 3compartmentss NA 95% Human Human -DTXSID1047071 Css NA 0.2536 mg/L PBTK NA 50% Human Human -DTXSID1047071 Css NA 1.242 mg/L PBTK NA 95% Human Human -DTXSID1047071 Clint NA 3.534 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047071 Fup NA 0.3716 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047071 Vd NA 1.702 L/kg 1compartment NA NA Rat Human +DTXSID1047071 TK.Half.Life NA 2.352 hours 1compartment NA NA Human Human +DTXSID1047071 Css NA 0.07121 mg/L 3compartmentss NA 50% Human Human +DTXSID1047071 Css NA 0.5669 mg/L 3compartmentss NA 95% Human Human +DTXSID1047071 Css NA 0.05755 mg/L PBTK NA 50% Human Human +DTXSID1047071 Css NA 0.4152 mg/L PBTK NA 95% Human Human +DTXSID1047071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047071 Fup 0.283 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047071 Vd NA 1.556 L/kg 1compartment NA NA Rat Human DTXSID1047071 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047071 TK.Half.Life NA 2.897 hours 1compartment NA NA Rat Human -DTXSID1047071 Css NA 0.1401 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047071 Css NA 0.6316 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047071 Css NA 0.117 mg/L PBTK NA 50% Rat Human -DTXSID1047071 Css NA 0.4246 mg/L PBTK NA 95% Rat Human -DTXSID1047075 Clint NA 1.872 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047075 Fup NA 0.8093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047075 Vd NA 1.178 L/kg 1compartment NA NA Human Human +DTXSID1047071 TK.Half.Life NA 1.057 hours 1compartment NA NA Rat Human +DTXSID1047071 Css NA 0.009063 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047071 Css NA 0.0509 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047071 Css NA 0.007326 mg/L PBTK NA 50% Rat Human +DTXSID1047071 Css NA 0.03717 mg/L PBTK NA 95% Rat Human +DTXSID1047075 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047075 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047075 Vd NA 1.075 L/kg 1compartment NA NA Human Human DTXSID1047075 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047075 TK.Half.Life NA 2.769 hours 1compartment NA NA Human Human -DTXSID1047075 Css NA 0.2318 mg/L 3compartmentss NA 50% Human Human -DTXSID1047075 Css NA 1.662 mg/L 3compartmentss NA 95% Human Human -DTXSID1047075 Css NA 0.2058 mg/L PBTK NA 50% Human Human -DTXSID1047075 Css NA 1.153 mg/L PBTK NA 95% Human Human -DTXSID1047075 Clint NA 1.872 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047075 Fup NA 0.8093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047075 Vd NA 1.109 L/kg 1compartment NA NA Rat Human +DTXSID1047075 TK.Half.Life NA 0.8787 hours 1compartment NA NA Human Human +DTXSID1047075 Css NA 0.02796 mg/L 3compartmentss NA 50% Human Human +DTXSID1047075 Css NA 0.3085 mg/L 3compartmentss NA 95% Human Human +DTXSID1047075 Css NA 0.02398 mg/L PBTK NA 50% Human Human +DTXSID1047075 Css NA 0.2186 mg/L PBTK NA 95% Human Human +DTXSID1047075 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047075 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047075 Vd NA 1.01 L/kg 1compartment NA NA Rat Human DTXSID1047075 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047075 TK.Half.Life NA 1.309 hours 1compartment NA NA Rat Human -DTXSID1047075 Css NA 0.09621 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047075 Css NA 0.6535 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047075 Css NA 0.0845 mg/L PBTK NA 50% Rat Human -DTXSID1047075 Css NA 0.4033 mg/L PBTK NA 95% Rat Human -DTXSID1047102 Clint NA 26.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047102 Fup NA 0.0606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047102 Vd NA 7.613 L/kg 1compartment NA NA Human Human -DTXSID1047102 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047102 TK.Half.Life NA 5.82 hours 1compartment NA NA Human Human -DTXSID1047102 Css NA 0.02506 mg/L 3compartmentss NA 50% Human Human -DTXSID1047102 Css NA 0.1787 mg/L 3compartmentss NA 95% Human Human -DTXSID1047102 Css NA 0.02828 mg/L PBTK NA 50% Human Human -DTXSID1047102 Css NA 0.1758 mg/L PBTK NA 95% Human Human -DTXSID1047102 Clint NA 26.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047102 Fup NA 0.0606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047102 Vd NA 6.239 L/kg 1compartment NA NA Rat Human -DTXSID1047102 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047102 TK.Half.Life NA 1.764 hours 1compartment NA NA Rat Human -DTXSID1047102 Css NA 0.01327 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047102 Css NA 0.07995 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047102 Css NA 0.01503 mg/L PBTK NA 50% Rat Human -DTXSID1047102 Css NA 0.07875 mg/L PBTK NA 95% Rat Human -DTXSID1047106 Clint NA 1.131 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047106 Fup NA 0.1206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047106 Vd NA 0.815 L/kg 1compartment NA NA Human Human -DTXSID1047106 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1047106 TK.Half.Life NA 16.1 hours 1compartment NA NA Human Human -DTXSID1047106 Css NA 2.824 mg/L 3compartmentss NA 50% Human Human -DTXSID1047106 Css NA 14.95 mg/L 3compartmentss NA 95% Human Human -DTXSID1047106 Css NA 1.872 mg/L PBTK NA 50% Human Human -DTXSID1047106 Css NA 9.075 mg/L PBTK NA 95% Human Human -DTXSID1047106 Clint NA 1.131 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047106 Fup NA 0.1206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047106 Vd NA 0.6599 L/kg 1compartment NA NA Rat Human +DTXSID1047075 TK.Half.Life NA 0.4028 hours 1compartment NA NA Rat Human +DTXSID1047075 Css NA 0.003319 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047075 Css NA 0.03125 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047075 Css NA 0.00289 mg/L PBTK NA 50% Rat Human +DTXSID1047075 Css NA 0.02176 mg/L PBTK NA 95% Rat Human +DTXSID1047106 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047106 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047106 Vd NA 0.8652 L/kg 1compartment NA NA Human Human +DTXSID1047106 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1047106 TK.Half.Life NA 1.826 hours 1compartment NA NA Human Human +DTXSID1047106 Css NA 0.1949 mg/L 3compartmentss NA 50% Human Human +DTXSID1047106 Css NA 1.535 mg/L 3compartmentss NA 95% Human Human +DTXSID1047106 Css NA 0.1309 mg/L PBTK NA 50% Human Human +DTXSID1047106 Css NA 0.9746 mg/L PBTK NA 95% Human Human +DTXSID1047106 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047106 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047106 Vd NA 0.7009 L/kg 1compartment NA NA Rat Human DTXSID1047106 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047106 TK.Half.Life NA 6.29 hours 1compartment NA NA Rat Human -DTXSID1047106 Css NA 1.206 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047106 Css NA 5.106 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047106 Css NA 0.7551 mg/L PBTK NA 50% Rat Human -DTXSID1047106 Css NA 2.898 mg/L PBTK NA 95% Rat Human -DTXSID1047150 Clint NA 1.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047150 Fup NA 0.044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047150 Vd NA 0.2169 L/kg 1compartment NA NA Human Human +DTXSID1047106 TK.Half.Life NA 0.8204 hours 1compartment NA NA Rat Human +DTXSID1047106 Css NA 0.02502 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047106 Css NA 0.1566 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047106 Css NA 0.0165 mg/L PBTK NA 50% Rat Human +DTXSID1047106 Css NA 0.09591 mg/L PBTK NA 95% Rat Human +DTXSID1047150 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047150 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047150 Vd NA 0.4281 L/kg 1compartment NA NA Human Human DTXSID1047150 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047150 TK.Half.Life NA 7.835 hours 1compartment NA NA Human Human -DTXSID1047150 Css NA 6.307 mg/L 3compartmentss NA 50% Human Human -DTXSID1047150 Css NA 39.55 mg/L 3compartmentss NA 95% Human Human -DTXSID1047150 Css NA 3.736 mg/L PBTK NA 50% Human Human -DTXSID1047150 Css NA 22.76 mg/L PBTK NA 95% Human Human -DTXSID1047150 Clint NA 1.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047150 Fup NA 0.044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047150 Vd NA 0.2111 L/kg 1compartment NA NA Rat Human +DTXSID1047150 TK.Half.Life NA 0.7552 hours 1compartment NA NA Human Human +DTXSID1047150 Css NA 0.1246 mg/L 3compartmentss NA 50% Human Human +DTXSID1047150 Css NA 0.928 mg/L 3compartmentss NA 95% Human Human +DTXSID1047150 Css NA 0.08234 mg/L PBTK NA 50% Human Human +DTXSID1047150 Css NA 0.585 mg/L PBTK NA 95% Human Human +DTXSID1047150 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047150 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047150 Vd NA 0.4028 L/kg 1compartment NA NA Rat Human DTXSID1047150 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047150 TK.Half.Life NA 4.227 hours 1compartment NA NA Rat Human -DTXSID1047150 Css NA 2.892 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047150 Css NA 14.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047150 Css NA 1.607 mg/L PBTK NA 50% Rat Human -DTXSID1047150 Css NA 8.051 mg/L PBTK NA 95% Rat Human -DTXSID1047158 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047158 Fup NA 0.4939 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047158 Vd NA 2.14 L/kg 1compartment NA NA Human Human -DTXSID1047158 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID1047158 TK.Half.Life NA 48.68 hours 1compartment NA NA Human Human -DTXSID1047158 Css NA 2.308 mg/L 3compartmentss NA 50% Human Human -DTXSID1047158 Css NA 9.463 mg/L 3compartmentss NA 95% Human Human -DTXSID1047158 Css NA 1.922 mg/L PBTK NA 50% Human Human -DTXSID1047158 Css NA 6.55 mg/L PBTK NA 95% Human Human -DTXSID1047158 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047158 Fup NA 0.4939 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047158 Vd NA 1.711 L/kg 1compartment NA NA Rat Human -DTXSID1047158 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1047158 TK.Half.Life NA 8.977 hours 1compartment NA NA Rat Human -DTXSID1047158 Css NA 0.6204 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047158 Css NA 2.192 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047158 Css NA 0.4983 mg/L PBTK NA 50% Rat Human -DTXSID1047158 Css NA 1.39 mg/L PBTK NA 95% Rat Human -DTXSID1047239 Clint NA 69.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047239 Fup NA 0.0517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047239 Vd NA 3.072 L/kg 1compartment NA NA Human Human -DTXSID1047239 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1047239 TK.Half.Life NA 19.18 hours 1compartment NA NA Human Human -DTXSID1047239 Css NA 0.6946 mg/L 3compartmentss NA 50% Human Human -DTXSID1047239 Css NA 4.442 mg/L 3compartmentss NA 95% Human Human -DTXSID1047239 Css NA 0.4811 mg/L PBTK NA 50% Human Human -DTXSID1047239 Css NA 3 mg/L PBTK NA 95% Human Human -DTXSID1047239 Clint NA 69.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047239 Fup NA 0.0517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047239 Vd NA 2.302 L/kg 1compartment NA NA Rat Human -DTXSID1047239 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047239 TK.Half.Life NA 3.144 hours 1compartment NA NA Rat Human -DTXSID1047239 Css NA 0.3876 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047239 Css NA 2.109 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047239 Css NA 0.2567 mg/L PBTK NA 50% Rat Human -DTXSID1047239 Css NA 1.379 mg/L PBTK NA 95% Rat Human -DTXSID1047281 Clint NA 29.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047281 Fup NA 0.0439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047281 Vd NA 0.2923 L/kg 1compartment NA NA Human Human +DTXSID1047150 TK.Half.Life NA 0.397 hours 1compartment NA NA Rat Human +DTXSID1047150 Css NA 0.01605 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047150 Css NA 0.08754 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047150 Css NA 0.01042 mg/L PBTK NA 50% Rat Human +DTXSID1047150 Css NA 0.05429 mg/L PBTK NA 95% Rat Human +DTXSID1047158 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047158 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047158 Vd NA 1.917 L/kg 1compartment NA NA Human Human +DTXSID1047158 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1047158 TK.Half.Life NA 2.522 hours 1compartment NA NA Human Human +DTXSID1047158 Css NA 0.07124 mg/L 3compartmentss NA 50% Human Human +DTXSID1047158 Css NA 0.4998 mg/L 3compartmentss NA 95% Human Human +DTXSID1047158 Css NA 0.05586 mg/L PBTK NA 50% Human Human +DTXSID1047158 Css NA 0.3615 mg/L PBTK NA 95% Human Human +DTXSID1047158 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047158 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047158 Vd NA 1.529 L/kg 1compartment NA NA Rat Human +DTXSID1047158 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1047158 TK.Half.Life NA 0.9129 hours 1compartment NA NA Rat Human +DTXSID1047158 Css NA 0.008775 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047158 Css NA 0.04887 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047158 Css NA 0.006942 mg/L PBTK NA 50% Rat Human +DTXSID1047158 Css NA 0.03482 mg/L PBTK NA 95% Rat Human +DTXSID1047239 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047239 Fup 0.0235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047239 Vd NA 2.82 L/kg 1compartment NA NA Human Human +DTXSID1047239 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1047239 TK.Half.Life NA 41.36 hours 1compartment NA NA Human Human +DTXSID1047239 Css NA 1.892 mg/L 3compartmentss NA 50% Human Human +DTXSID1047239 Css NA 13.53 mg/L 3compartmentss NA 95% Human Human +DTXSID1047239 Css NA 1.276 mg/L PBTK NA 50% Human Human +DTXSID1047239 Css NA 8.741 mg/L PBTK NA 95% Human Human +DTXSID1047239 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047239 Fup 0.0235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047239 Vd NA 2.109 L/kg 1compartment NA NA Rat Human +DTXSID1047239 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1047239 TK.Half.Life NA 8.006 hours 1compartment NA NA Rat Human +DTXSID1047239 Css NA 0.2447 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047239 Css NA 1.429 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047239 Css NA 0.1633 mg/L PBTK NA 50% Rat Human +DTXSID1047239 Css NA 0.9297 mg/L PBTK NA 95% Rat Human +DTXSID1047281 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047281 Fup 0.0562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047281 Vd NA 0.2744 L/kg 1compartment NA NA Human Human DTXSID1047281 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047281 TK.Half.Life NA 1.129 hours 1compartment NA NA Human Human -DTXSID1047281 Css NA 0.5484 mg/L 3compartmentss NA 50% Human Human -DTXSID1047281 Css NA 5.039 mg/L 3compartmentss NA 95% Human Human -DTXSID1047281 Css NA 0.3337 mg/L PBTK NA 50% Human Human -DTXSID1047281 Css NA 2.998 mg/L PBTK NA 95% Human Human -DTXSID1047281 Clint NA 29.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047281 Fup NA 0.0439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047281 Vd NA 0.2844 L/kg 1compartment NA NA Rat Human +DTXSID1047281 TK.Half.Life NA 2.997 hours 1compartment NA NA Human Human +DTXSID1047281 Css NA 1.55 mg/L 3compartmentss NA 50% Human Human +DTXSID1047281 Css NA 11.04 mg/L 3compartmentss NA 95% Human Human +DTXSID1047281 Css NA 0.9398 mg/L PBTK NA 50% Human Human +DTXSID1047281 Css NA 6.544 mg/L PBTK NA 95% Human Human +DTXSID1047281 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047281 Fup 0.0562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047281 Vd NA 0.2694 L/kg 1compartment NA NA Rat Human DTXSID1047281 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047281 TK.Half.Life NA 0.6876 hours 1compartment NA NA Rat Human -DTXSID1047281 Css NA 0.3049 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047281 Css NA 2.231 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047281 Css NA 0.1745 mg/L PBTK NA 50% Rat Human -DTXSID1047281 Css NA 1.235 mg/L PBTK NA 95% Rat Human -DTXSID1047283 Clint NA 85.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047283 Fup NA 0.0726 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047283 Vd NA 3.107 L/kg 1compartment NA NA Human Human -DTXSID1047283 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047283 TK.Half.Life NA 13.84 hours 1compartment NA NA Human Human -DTXSID1047283 Css NA 0.4556 mg/L 3compartmentss NA 50% Human Human -DTXSID1047283 Css NA 3.071 mg/L 3compartmentss NA 95% Human Human -DTXSID1047283 Css NA 0.3199 mg/L PBTK NA 50% Human Human -DTXSID1047283 Css NA 2.051 mg/L PBTK NA 95% Human Human -DTXSID1047283 Clint NA 85.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047283 Fup NA 0.0726 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047283 Vd NA 2.344 L/kg 1compartment NA NA Rat Human -DTXSID1047283 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047283 TK.Half.Life NA 2.438 hours 1compartment NA NA Rat Human -DTXSID1047283 Css NA 0.2563 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047283 Css NA 1.372 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047283 Css NA 0.1716 mg/L PBTK NA 50% Rat Human -DTXSID1047283 Css NA 0.8919 mg/L PBTK NA 95% Rat Human +DTXSID1047281 TK.Half.Life NA 1.831 hours 1compartment NA NA Rat Human +DTXSID1047281 Css NA 0.07067 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047281 Css NA 0.577 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047281 Css NA 0.04145 mg/L PBTK NA 50% Rat Human +DTXSID1047281 Css NA 0.3283 mg/L PBTK NA 95% Rat Human +DTXSID1047283 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047283 Fup 0.0737 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047283 Vd NA 3.052 L/kg 1compartment NA NA Human Human +DTXSID1047283 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1047283 TK.Half.Life NA 33.6 hours 1compartment NA NA Human Human +DTXSID1047283 Css NA 1.27 mg/L 3compartmentss NA 50% Human Human +DTXSID1047283 Css NA 7.927 mg/L 3compartmentss NA 95% Human Human +DTXSID1047283 Css NA 0.8958 mg/L PBTK NA 50% Human Human +DTXSID1047283 Css NA 5.455 mg/L PBTK NA 95% Human Human +DTXSID1047283 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047283 Fup 0.0737 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047283 Vd NA 2.314 L/kg 1compartment NA NA Rat Human +DTXSID1047283 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1047283 TK.Half.Life NA 5.738 hours 1compartment NA NA Rat Human +DTXSID1047283 Css NA 0.1628 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047283 Css NA 0.9 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047283 Css NA 0.1136 mg/L PBTK NA 50% Rat Human +DTXSID1047283 Css NA 0.6022 mg/L PBTK NA 95% Rat Human DTXSID1047285 Clint 3.688 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID1047285 Fup 1 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID1047285 Vd NA 5.34 L/kg 1compartment NA NA Human Human +DTXSID1047285 Vd NA 5.17 L/kg 1compartment NA NA Human Human DTXSID1047285 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047285 TK.Half.Life NA 5.747 hours 1compartment NA NA Human Human -DTXSID1047285 Css NA 0.06238 mg/L 3compartmentss NA 50% Human Human -DTXSID1047285 Css NA 0.742 mg/L 3compartmentss NA 95% Human Human -DTXSID1047285 Css NA 0.09841 mg/L PBTK NA 50% Human Human -DTXSID1047285 Css NA 0.7178 mg/L PBTK NA 95% Human Human +DTXSID1047285 TK.Half.Life NA 5.603 hours 1compartment NA NA Human Human +DTXSID1047285 Css NA 0.04812 mg/L 3compartmentss NA 50% Human Human +DTXSID1047285 Css NA 0.6114 mg/L 3compartmentss NA 95% Human Human +DTXSID1047285 Css NA 0.07514 mg/L PBTK NA 50% Human Human +DTXSID1047285 Css NA 0.5821 mg/L PBTK NA 95% Human Human DTXSID1047285 Clint 3.688 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID1047285 Fup 1 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID1047285 Vd NA 5.456 L/kg 1compartment NA NA Rat Human +DTXSID1047285 Vd NA 5.281 L/kg 1compartment NA NA Rat Human DTXSID1047285 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047285 TK.Half.Life NA 3.285 hours 1compartment NA NA Rat Human -DTXSID1047285 Css NA 0.0268 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047285 Css NA 0.275 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047285 Css NA 0.04465 mg/L PBTK NA 50% Rat Human -DTXSID1047285 Css NA 0.2327 mg/L PBTK NA 95% Rat Human -DTXSID1047287 Clint NA 1.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047287 Fup NA 0.0477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047287 Vd NA 0.3898 L/kg 1compartment NA NA Human Human -DTXSID1047287 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1047287 TK.Half.Life NA 16.89 hours 1compartment NA NA Human Human -DTXSID1047287 Css NA 7.38 mg/L 3compartmentss NA 50% Human Human -DTXSID1047287 Css NA 44.34 mg/L 3compartmentss NA 95% Human Human -DTXSID1047287 Css NA 4.452 mg/L PBTK NA 50% Human Human -DTXSID1047287 Css NA 25.59 mg/L PBTK NA 95% Human Human -DTXSID1047287 Clint NA 1.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047287 Fup NA 0.0477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047287 Vd NA 0.3316 L/kg 1compartment NA NA Rat Human +DTXSID1047285 TK.Half.Life NA 3.197 hours 1compartment NA NA Rat Human +DTXSID1047285 Css NA 0.0009735 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047285 Css NA 0.01519 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047285 Css NA 0.001552 mg/L PBTK NA 50% Rat Human +DTXSID1047285 Css NA 0.01568 mg/L PBTK NA 95% Rat Human +DTXSID1047287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047287 Fup 0.071 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047287 Vd NA 2.033 L/kg 1compartment NA NA Human Human +DTXSID1047287 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1047287 TK.Half.Life NA 8.747 hours 1compartment NA NA Human Human +DTXSID1047287 Css NA 0.4736 mg/L 3compartmentss NA 50% Human Human +DTXSID1047287 Css NA 3.155 mg/L 3compartmentss NA 95% Human Human +DTXSID1047287 Css NA 0.3162 mg/L PBTK NA 50% Human Human +DTXSID1047287 Css NA 2.027 mg/L PBTK NA 95% Human Human +DTXSID1047287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047287 Fup 0.071 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047287 Vd NA 1.527 L/kg 1compartment NA NA Rat Human DTXSID1047287 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047287 TK.Half.Life NA 7.456 hours 1compartment NA NA Rat Human -DTXSID1047287 Css NA 3.274 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047287 Css NA 14.98 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047287 Css NA 1.847 mg/L PBTK NA 50% Rat Human -DTXSID1047287 Css NA 8.146 mg/L PBTK NA 95% Rat Human -DTXSID1047289 Clint NA 17.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047289 Fup NA 0.1158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047289 Vd NA 2.249 L/kg 1compartment NA NA Human Human +DTXSID1047287 TK.Half.Life NA 2.823 hours 1compartment NA NA Rat Human +DTXSID1047287 Css NA 0.06112 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047287 Css NA 0.3142 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047287 Css NA 0.04027 mg/L PBTK NA 50% Rat Human +DTXSID1047287 Css NA 0.2034 mg/L PBTK NA 95% Rat Human +DTXSID1047289 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047289 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047289 Vd NA 1.516 L/kg 1compartment NA NA Human Human DTXSID1047289 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047289 TK.Half.Life NA 4.699 hours 1compartment NA NA Human Human -DTXSID1047289 Css NA 0.1868 mg/L 3compartmentss NA 50% Human Human -DTXSID1047289 Css NA 1.656 mg/L 3compartmentss NA 95% Human Human -DTXSID1047289 Css NA 0.1578 mg/L PBTK NA 50% Human Human -DTXSID1047289 Css NA 1.182 mg/L PBTK NA 95% Human Human -DTXSID1047289 Clint NA 17.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047289 Fup NA 0.1158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047289 Vd NA 2.239 L/kg 1compartment NA NA Rat Human +DTXSID1047289 TK.Half.Life NA 2.864 hours 1compartment NA NA Human Human +DTXSID1047289 Css NA 0.136 mg/L 3compartmentss NA 50% Human Human +DTXSID1047289 Css NA 1.236 mg/L 3compartmentss NA 95% Human Human +DTXSID1047289 Css NA 0.104 mg/L PBTK NA 50% Human Human +DTXSID1047289 Css NA 0.845 mg/L PBTK NA 95% Human Human +DTXSID1047289 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047289 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047289 Vd NA 1.508 L/kg 1compartment NA NA Rat Human DTXSID1047289 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047289 TK.Half.Life NA 2.788 hours 1compartment NA NA Rat Human -DTXSID1047289 Css NA 0.1029 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047289 Css NA 0.7042 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047289 Css NA 0.08318 mg/L PBTK NA 50% Rat Human -DTXSID1047289 Css NA 0.4644 mg/L PBTK NA 95% Rat Human -DTXSID1047310 Clint NA 5.398 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047310 Fup NA 0.0017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047310 Vd NA 6.323 L/kg 1compartment NA NA Human Human -DTXSID1047310 Days.Css NA 193 Days PBTK NA NA Human Human -DTXSID1047310 TK.Half.Life NA 793.3 hours 1compartment NA NA Human Human -DTXSID1047310 Css NA 13.94 mg/L 3compartmentss NA 50% Human Human -DTXSID1047310 Css NA 96.74 mg/L 3compartmentss NA 95% Human Human -DTXSID1047310 Css NA 12.14 mg/L PBTK NA 50% Human Human -DTXSID1047310 Css NA 77.71 mg/L PBTK NA 95% Human Human -DTXSID1047310 Clint NA 5.398 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047310 Fup NA 0.0017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047310 Vd NA 4.878 L/kg 1compartment NA NA Rat Human -DTXSID1047310 Days.Css NA 108 Days PBTK NA NA Rat Human -DTXSID1047310 TK.Half.Life NA 171.8 hours 1compartment NA NA Rat Human -DTXSID1047310 Css NA 7.611 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047310 Css NA 40.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047310 Css NA 6.512 mg/L PBTK NA 50% Rat Human -DTXSID1047310 Css NA 30.85 mg/L PBTK NA 95% Rat Human -DTXSID1047312 Clint NA 28.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047312 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047312 Vd NA 0.5549 L/kg 1compartment NA NA Human Human +DTXSID1047289 TK.Half.Life NA 1.675 hours 1compartment NA NA Rat Human +DTXSID1047289 Css NA 0.006373 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047289 Css NA 0.06746 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047289 Css NA 0.004876 mg/L PBTK NA 50% Rat Human +DTXSID1047289 Css NA 0.04382 mg/L PBTK NA 95% Rat Human +DTXSID1047310 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047310 Fup 0.00951 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047310 Vd NA 2.688 L/kg 1compartment NA NA Human Human +DTXSID1047310 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID1047310 TK.Half.Life NA 52.67 hours 1compartment NA NA Human Human +DTXSID1047310 Css NA 2.672 mg/L 3compartmentss NA 50% Human Human +DTXSID1047310 Css NA 19.56 mg/L 3compartmentss NA 95% Human Human +DTXSID1047310 Css NA 1.778 mg/L PBTK NA 50% Human Human +DTXSID1047310 Css NA 12.44 mg/L PBTK NA 95% Human Human +DTXSID1047310 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047310 Fup 0.00951 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047310 Vd NA 2.004 L/kg 1compartment NA NA Rat Human +DTXSID1047310 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID1047310 TK.Half.Life NA 11.2 hours 1compartment NA NA Rat Human +DTXSID1047310 Css NA 0.3466 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047310 Css NA 2.13 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047310 Css NA 0.2275 mg/L PBTK NA 50% Rat Human +DTXSID1047310 Css NA 1.367 mg/L PBTK NA 95% Rat Human +DTXSID1047312 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047312 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047312 Vd NA 0.8649 L/kg 1compartment NA NA Human Human DTXSID1047312 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047312 TK.Half.Life NA 1.615 hours 1compartment NA NA Human Human -DTXSID1047312 Css NA 0.3599 mg/L 3compartmentss NA 50% Human Human -DTXSID1047312 Css NA 2.934 mg/L 3compartmentss NA 95% Human Human -DTXSID1047312 Css NA 0.222 mg/L PBTK NA 50% Human Human -DTXSID1047312 Css NA 1.745 mg/L PBTK NA 95% Human Human -DTXSID1047312 Clint NA 28.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047312 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047312 Vd NA 0.4472 L/kg 1compartment NA NA Rat Human +DTXSID1047312 TK.Half.Life NA 2.027 hours 1compartment NA NA Human Human +DTXSID1047312 Css NA 0.2359 mg/L 3compartmentss NA 50% Human Human +DTXSID1047312 Css NA 1.854 mg/L 3compartmentss NA 95% Human Human +DTXSID1047312 Css NA 0.153 mg/L PBTK NA 50% Human Human +DTXSID1047312 Css NA 1.146 mg/L PBTK NA 95% Human Human +DTXSID1047312 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047312 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047312 Vd NA 0.6856 L/kg 1compartment NA NA Rat Human DTXSID1047312 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047312 TK.Half.Life NA 0.7711 hours 1compartment NA NA Rat Human -DTXSID1047312 Css NA 0.206 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047312 Css NA 1.258 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047312 Css NA 0.1185 mg/L PBTK NA 50% Rat Human -DTXSID1047312 Css NA 0.6981 mg/L PBTK NA 95% Rat Human -DTXSID1047316 Clint NA 74.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047316 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047316 Vd NA 3.085 L/kg 1compartment NA NA Human Human -DTXSID1047316 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1047316 TK.Half.Life NA 16.49 hours 1compartment NA NA Human Human -DTXSID1047316 Css NA 0.5664 mg/L 3compartmentss NA 50% Human Human -DTXSID1047316 Css NA 3.743 mg/L 3compartmentss NA 95% Human Human -DTXSID1047316 Css NA 0.3962 mg/L PBTK NA 50% Human Human -DTXSID1047316 Css NA 2.516 mg/L PBTK NA 95% Human Human -DTXSID1047316 Clint NA 74.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047316 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047316 Vd NA 2.314 L/kg 1compartment NA NA Rat Human -DTXSID1047316 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047316 TK.Half.Life NA 2.742 hours 1compartment NA NA Rat Human -DTXSID1047316 Css NA 0.3232 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047316 Css NA 1.756 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047316 Css NA 0.2152 mg/L PBTK NA 50% Rat Human -DTXSID1047316 Css NA 1.134 mg/L PBTK NA 95% Rat Human -DTXSID1047318 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047318 Fup NA 0.0835 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047318 Vd NA 1.198 L/kg 1compartment NA NA Human Human -DTXSID1047318 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID1047318 TK.Half.Life NA 113.8 hours 1compartment NA NA Human Human -DTXSID1047318 Css NA 14.02 mg/L 3compartmentss NA 50% Human Human -DTXSID1047318 Css NA 60.74 mg/L 3compartmentss NA 95% Human Human -DTXSID1047318 Css NA 9.072 mg/L PBTK NA 50% Human Human -DTXSID1047318 Css NA 36.49 mg/L PBTK NA 95% Human Human -DTXSID1047318 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047318 Fup NA 0.0835 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047318 Vd NA 0.9227 L/kg 1compartment NA NA Rat Human -DTXSID1047318 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1047318 TK.Half.Life NA 25.67 hours 1compartment NA NA Rat Human -DTXSID1047318 Css NA 3.936 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047318 Css NA 14.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047318 Css NA 2.395 mg/L PBTK NA 50% Rat Human -DTXSID1047318 Css NA 7.917 mg/L PBTK NA 95% Rat Human -DTXSID1047360 Clint NA 41.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047360 Fup NA 0.0827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047360 Vd NA 2.638 L/kg 1compartment NA NA Human Human +DTXSID1047312 TK.Half.Life NA 0.8961 hours 1compartment NA NA Rat Human +DTXSID1047312 Css NA 0.03007 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047312 Css NA 0.1932 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047312 Css NA 0.01905 mg/L PBTK NA 50% Rat Human +DTXSID1047312 Css NA 0.1174 mg/L PBTK NA 95% Rat Human +DTXSID1047316 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047316 Fup 0.0861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047316 Vd NA 2.888 L/kg 1compartment NA NA Human Human +DTXSID1047316 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1047316 TK.Half.Life NA 23.13 hours 1compartment NA NA Human Human +DTXSID1047316 Css NA 0.8664 mg/L 3compartmentss NA 50% Human Human +DTXSID1047316 Css NA 5.945 mg/L 3compartmentss NA 95% Human Human +DTXSID1047316 Css NA 0.6042 mg/L PBTK NA 50% Human Human +DTXSID1047316 Css NA 3.944 mg/L PBTK NA 95% Human Human +DTXSID1047316 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047316 Fup 0.0861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047316 Vd NA 2.17 L/kg 1compartment NA NA Rat Human +DTXSID1047316 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1047316 TK.Half.Life NA 4.409 hours 1compartment NA NA Rat Human +DTXSID1047316 Css NA 0.0768 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047316 Css NA 0.4177 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047316 Css NA 0.05264 mg/L PBTK NA 50% Rat Human +DTXSID1047316 Css NA 0.2629 mg/L PBTK NA 95% Rat Human +DTXSID1047318 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047318 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047318 Vd NA 1.876 L/kg 1compartment NA NA Human Human +DTXSID1047318 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1047318 TK.Half.Life NA 11.82 hours 1compartment NA NA Human Human +DTXSID1047318 Css NA 0.7664 mg/L 3compartmentss NA 50% Human Human +DTXSID1047318 Css NA 4.712 mg/L 3compartmentss NA 95% Human Human +DTXSID1047318 Css NA 0.5319 mg/L PBTK NA 50% Human Human +DTXSID1047318 Css NA 3.072 mg/L PBTK NA 95% Human Human +DTXSID1047318 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047318 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047318 Vd NA 1.437 L/kg 1compartment NA NA Rat Human +DTXSID1047318 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1047318 TK.Half.Life NA 4.021 hours 1compartment NA NA Rat Human +DTXSID1047318 Css NA 0.093 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047318 Css NA 0.4222 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047318 Css NA 0.06326 mg/L PBTK NA 50% Rat Human +DTXSID1047318 Css NA 0.2683 mg/L PBTK NA 95% Rat Human +DTXSID1047360 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047360 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047360 Vd NA 1.844 L/kg 1compartment NA NA Human Human DTXSID1047360 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047360 TK.Half.Life NA 3.614 hours 1compartment NA NA Human Human -DTXSID1047360 Css NA 0.09551 mg/L 3compartmentss NA 50% Human Human -DTXSID1047360 Css NA 0.855 mg/L 3compartmentss NA 95% Human Human -DTXSID1047360 Css NA 0.07864 mg/L PBTK NA 50% Human Human -DTXSID1047360 Css NA 0.6125 mg/L PBTK NA 95% Human Human -DTXSID1047360 Clint NA 41.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047360 Fup NA 0.0827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047360 Vd NA 2.486 L/kg 1compartment NA NA Rat Human +DTXSID1047360 TK.Half.Life NA 9.391 hours 1compartment NA NA Human Human +DTXSID1047360 Css NA 0.58 mg/L 3compartmentss NA 50% Human Human +DTXSID1047360 Css NA 4.515 mg/L 3compartmentss NA 95% Human Human +DTXSID1047360 Css NA 0.453 mg/L PBTK NA 50% Human Human +DTXSID1047360 Css NA 2.984 mg/L PBTK NA 95% Human Human +DTXSID1047360 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047360 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047360 Vd NA 1.827 L/kg 1compartment NA NA Rat Human DTXSID1047360 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047360 TK.Half.Life NA 1.782 hours 1compartment NA NA Rat Human -DTXSID1047360 Css NA 0.05313 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047360 Css NA 0.3908 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047360 Css NA 0.04238 mg/L PBTK NA 50% Rat Human -DTXSID1047360 Css NA 0.2659 mg/L PBTK NA 95% Rat Human -DTXSID1047362 Clint NA 28.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047362 Fup NA 0.0494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047362 Vd NA 1.236 L/kg 1compartment NA NA Human Human +DTXSID1047360 TK.Half.Life NA 5.658 hours 1compartment NA NA Rat Human +DTXSID1047360 Css NA 0.07034 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047360 Css NA 0.4295 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047360 Css NA 0.05494 mg/L PBTK NA 50% Rat Human +DTXSID1047360 Css NA 0.2749 mg/L PBTK NA 95% Rat Human +DTXSID1047362 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047362 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047362 Vd NA 2.916 L/kg 1compartment NA NA Human Human DTXSID1047362 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047362 TK.Half.Life NA 3.485 hours 1compartment NA NA Human Human -DTXSID1047362 Css NA 0.3335 mg/L 3compartmentss NA 50% Human Human -DTXSID1047362 Css NA 3.133 mg/L 3compartmentss NA 95% Human Human -DTXSID1047362 Css NA 0.2292 mg/L PBTK NA 50% Human Human -DTXSID1047362 Css NA 1.969 mg/L PBTK NA 95% Human Human -DTXSID1047362 Clint NA 28.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047362 Fup NA 0.0494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047362 Vd NA 1.215 L/kg 1compartment NA NA Rat Human +DTXSID1047362 TK.Half.Life NA 3.815 hours 1compartment NA NA Human Human +DTXSID1047362 Css NA 0.06618 mg/L 3compartmentss NA 50% Human Human +DTXSID1047362 Css NA 0.5611 mg/L 3compartmentss NA 95% Human Human +DTXSID1047362 Css NA 0.06704 mg/L PBTK NA 50% Human Human +DTXSID1047362 Css NA 0.4767 mg/L PBTK NA 95% Human Human +DTXSID1047362 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047362 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047362 Vd NA 2.929 L/kg 1compartment NA NA Rat Human DTXSID1047362 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047362 TK.Half.Life NA 2.107 hours 1compartment NA NA Rat Human -DTXSID1047362 Css NA 0.1854 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047362 Css NA 1.391 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047362 Css NA 0.1212 mg/L PBTK NA 50% Rat Human -DTXSID1047362 Css NA 0.831 mg/L PBTK NA 95% Rat Human -DTXSID1047364 Clint NA 11.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047364 Fup NA 0.0234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047364 Vd NA 2.975 L/kg 1compartment NA NA Human Human -DTXSID1047364 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047364 TK.Half.Life NA 10.43 hours 1compartment NA NA Human Human -DTXSID1047364 Css NA 0.3822 mg/L 3compartmentss NA 50% Human Human -DTXSID1047364 Css NA 2.98 mg/L 3compartmentss NA 95% Human Human -DTXSID1047364 Css NA 0.2801 mg/L PBTK NA 50% Human Human -DTXSID1047364 Css NA 2.014 mg/L PBTK NA 95% Human Human -DTXSID1047364 Clint NA 11.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047364 Fup NA 0.0234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047364 Vd NA 2.391 L/kg 1compartment NA NA Rat Human -DTXSID1047364 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047364 TK.Half.Life NA 2.957 hours 1compartment NA NA Rat Human -DTXSID1047364 Css NA 0.2126 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047364 Css NA 1.415 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047364 Css NA 0.1485 mg/L PBTK NA 50% Rat Human -DTXSID1047364 Css NA 0.8976 mg/L PBTK NA 95% Rat Human -DTXSID1047366 Clint NA 19.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047366 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047366 Vd NA 2.994 L/kg 1compartment NA NA Human Human -DTXSID1047366 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID1047366 TK.Half.Life NA 79.24 hours 1compartment NA NA Human Human -DTXSID1047366 Css NA 3.412 mg/L 3compartmentss NA 50% Human Human -DTXSID1047366 Css NA 21.8 mg/L 3compartmentss NA 95% Human Human -DTXSID1047366 Css NA 2.328 mg/L PBTK NA 50% Human Human -DTXSID1047366 Css NA 14.49 mg/L PBTK NA 95% Human Human -DTXSID1047366 Clint NA 19.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047366 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047366 Vd NA 2.241 L/kg 1compartment NA NA Rat Human -DTXSID1047366 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID1047366 TK.Half.Life NA 12.53 hours 1compartment NA NA Rat Human -DTXSID1047366 Css NA 1.898 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047366 Css NA 10.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047366 Css NA 1.242 mg/L PBTK NA 50% Rat Human -DTXSID1047366 Css NA 6.528 mg/L PBTK NA 95% Rat Human -DTXSID1047368 Clint NA 88.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047368 Fup NA 0.2007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047368 Vd NA 2.321 L/kg 1compartment NA NA Human Human +DTXSID1047362 TK.Half.Life NA 2.197 hours 1compartment NA NA Rat Human +DTXSID1047362 Css NA 0.008216 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047362 Css NA 0.05294 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047362 Css NA 0.008657 mg/L PBTK NA 50% Rat Human +DTXSID1047362 Css NA 0.04574 mg/L PBTK NA 95% Rat Human +DTXSID1047366 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047366 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047366 Vd NA 5.056 L/kg 1compartment NA NA Human Human +DTXSID1047366 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID1047366 TK.Half.Life NA 152.4 hours 1compartment NA NA Human Human +DTXSID1047366 Css NA 2.932 mg/L 3compartmentss NA 50% Human Human +DTXSID1047366 Css NA 17.55 mg/L 3compartmentss NA 95% Human Human +DTXSID1047366 Css NA 2.386 mg/L PBTK NA 50% Human Human +DTXSID1047366 Css NA 14 mg/L PBTK NA 95% Human Human +DTXSID1047366 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047366 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047366 Vd NA 3.863 L/kg 1compartment NA NA Rat Human +DTXSID1047366 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID1047366 TK.Half.Life NA 20.77 hours 1compartment NA NA Rat Human +DTXSID1047366 Css NA 0.3754 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047366 Css NA 1.92 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047366 Css NA 0.306 mg/L PBTK NA 50% Rat Human +DTXSID1047366 Css NA 1.621 mg/L PBTK NA 95% Rat Human +DTXSID1047368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047368 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047368 Vd NA 0.4652 L/kg 1compartment NA NA Human Human DTXSID1047368 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047368 TK.Half.Life NA 2.605 hours 1compartment NA NA Human Human -DTXSID1047368 Css NA 0.04532 mg/L 3compartmentss NA 50% Human Human -DTXSID1047368 Css NA 0.3037 mg/L 3compartmentss NA 95% Human Human -DTXSID1047368 Css NA 0.0333 mg/L PBTK NA 50% Human Human -DTXSID1047368 Css NA 0.2109 mg/L PBTK NA 95% Human Human -DTXSID1047368 Clint NA 88.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047368 Fup NA 0.2007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047368 Vd NA 1.813 L/kg 1compartment NA NA Rat Human +DTXSID1047368 TK.Half.Life NA 2.335 hours 1compartment NA NA Human Human +DTXSID1047368 Css NA 0.5818 mg/L 3compartmentss NA 50% Human Human +DTXSID1047368 Css NA 4.055 mg/L 3compartmentss NA 95% Human Human +DTXSID1047368 Css NA 0.3698 mg/L PBTK NA 50% Human Human +DTXSID1047368 Css NA 2.415 mg/L PBTK NA 95% Human Human +DTXSID1047368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047368 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047368 Vd NA 0.4083 L/kg 1compartment NA NA Rat Human DTXSID1047368 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047368 TK.Half.Life NA 0.8643 hours 1compartment NA NA Rat Human -DTXSID1047368 Css NA 0.02506 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047368 Css NA 0.1356 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047368 Css NA 0.01782 mg/L PBTK NA 50% Rat Human -DTXSID1047368 Css NA 0.08803 mg/L PBTK NA 95% Rat Human -DTXSID1047443 Clint NA 36.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047443 Fup NA 0.3833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047443 Vd NA 1.404 L/kg 1compartment NA NA Human Human +DTXSID1047368 TK.Half.Life NA 1.221 hours 1compartment NA NA Rat Human +DTXSID1047368 Css NA 0.02603 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047368 Css NA 0.2132 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047368 Css NA 0.01615 mg/L PBTK NA 50% Rat Human +DTXSID1047368 Css NA 0.1243 mg/L PBTK NA 95% Rat Human +DTXSID1047443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047443 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047443 Vd NA 0.7803 L/kg 1compartment NA NA Human Human DTXSID1047443 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047443 TK.Half.Life NA 1.372 hours 1compartment NA NA Human Human -DTXSID1047443 Css NA 0.03538 mg/L 3compartmentss NA 50% Human Human -DTXSID1047443 Css NA 0.2681 mg/L 3compartmentss NA 95% Human Human -DTXSID1047443 Css NA 0.02794 mg/L PBTK NA 50% Human Human -DTXSID1047443 Css NA 0.1906 mg/L PBTK NA 95% Human Human -DTXSID1047443 Clint NA 36.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047443 Fup NA 0.3833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047443 Vd NA 1.169 L/kg 1compartment NA NA Rat Human +DTXSID1047443 TK.Half.Life NA 0.8469 hours 1compartment NA NA Human Human +DTXSID1047443 Css NA 0.04557 mg/L 3compartmentss NA 50% Human Human +DTXSID1047443 Css NA 0.3775 mg/L 3compartmentss NA 95% Human Human +DTXSID1047443 Css NA 0.03496 mg/L PBTK NA 50% Human Human +DTXSID1047443 Css NA 0.2595 mg/L PBTK NA 95% Human Human +DTXSID1047443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047443 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047443 Vd NA 0.7338 L/kg 1compartment NA NA Rat Human DTXSID1047443 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047443 TK.Half.Life NA 0.5441 hours 1compartment NA NA Rat Human -DTXSID1047443 Css NA 0.01911 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047443 Css NA 0.1142 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047443 Css NA 0.01458 mg/L PBTK NA 50% Rat Human -DTXSID1047443 Css NA 0.08087 mg/L PBTK NA 95% Rat Human -DTXSID1047447 Clint NA 101.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047447 Fup NA 0.5112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047447 Vd NA 0.7025 L/kg 1compartment NA NA Human Human +DTXSID1047443 TK.Half.Life NA 0.4073 hours 1compartment NA NA Rat Human +DTXSID1047443 Css NA 0.005575 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047443 Css NA 0.03711 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047443 Css NA 0.004296 mg/L PBTK NA 50% Rat Human +DTXSID1047443 Css NA 0.02493 mg/L PBTK NA 95% Rat Human +DTXSID1047447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047447 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047447 Vd NA 0.7339 L/kg 1compartment NA NA Human Human DTXSID1047447 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047447 TK.Half.Life NA 0.5243 hours 1compartment NA NA Human Human -DTXSID1047447 Css NA 0.008944 mg/L 3compartmentss NA 50% Human Human -DTXSID1047447 Css NA 0.08742 mg/L 3compartmentss NA 95% Human Human -DTXSID1047447 Css NA 0.006946 mg/L PBTK NA 50% Human Human -DTXSID1047447 Css NA 0.05838 mg/L PBTK NA 95% Human Human -DTXSID1047447 Clint NA 101.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047447 Fup NA 0.5112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047447 Vd NA 0.6918 L/kg 1compartment NA NA Rat Human +DTXSID1047447 TK.Half.Life NA 0.689 hours 1compartment NA NA Human Human +DTXSID1047447 Css NA 0.03524 mg/L 3compartmentss NA 50% Human Human +DTXSID1047447 Css NA 0.3836 mg/L 3compartmentss NA 95% Human Human +DTXSID1047447 Css NA 0.02775 mg/L PBTK NA 50% Human Human +DTXSID1047447 Css NA 0.2589 mg/L PBTK NA 95% Human Human +DTXSID1047447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047447 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047447 Vd NA 0.7252 L/kg 1compartment NA NA Rat Human DTXSID1047447 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047447 TK.Half.Life NA 0.2343 hours 1compartment NA NA Rat Human -DTXSID1047447 Css NA 0.004833 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047447 Css NA 0.03911 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047447 Css NA 0.00363 mg/L PBTK NA 50% Rat Human -DTXSID1047447 Css NA 0.02507 mg/L PBTK NA 95% Rat Human -DTXSID1047491 Clint NA 1.892 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047491 Fup NA 0.9576 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047491 Vd NA 1.462 L/kg 1compartment NA NA Human Human +DTXSID1047447 TK.Half.Life NA 0.3396 hours 1compartment NA NA Rat Human +DTXSID1047447 Css NA 0.004322 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047447 Css NA 0.03969 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047447 Css NA 0.003433 mg/L PBTK NA 50% Rat Human +DTXSID1047447 Css NA 0.0259 mg/L PBTK NA 95% Rat Human +DTXSID1047491 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047491 Fup 0.436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047491 Vd NA 0.9223 L/kg 1compartment NA NA Human Human DTXSID1047491 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047491 TK.Half.Life NA 3.031 hours 1compartment NA NA Human Human -DTXSID1047491 Css NA 0.2058 mg/L 3compartmentss NA 50% Human Human -DTXSID1047491 Css NA 1.385 mg/L 3compartmentss NA 95% Human Human -DTXSID1047491 Css NA 0.1901 mg/L PBTK NA 50% Human Human -DTXSID1047491 Css NA 0.985 mg/L PBTK NA 95% Human Human -DTXSID1047491 Clint NA 1.892 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047491 Fup NA 0.9576 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047491 Vd NA 1.343 L/kg 1compartment NA NA Rat Human +DTXSID1047491 TK.Half.Life NA 1.764 hours 1compartment NA NA Human Human +DTXSID1047491 Css NA 0.1444 mg/L 3compartmentss NA 50% Human Human +DTXSID1047491 Css NA 1.01 mg/L 3compartmentss NA 95% Human Human +DTXSID1047491 Css NA 0.1132 mg/L PBTK NA 50% Human Human +DTXSID1047491 Css NA 0.6922 mg/L PBTK NA 95% Human Human +DTXSID1047491 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047491 Fup 0.436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047491 Vd NA 0.841 L/kg 1compartment NA NA Rat Human DTXSID1047491 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047491 TK.Half.Life NA 1.352 hours 1compartment NA NA Rat Human -DTXSID1047491 Css NA 0.08366 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047491 Css NA 0.5257 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047491 Css NA 0.07736 mg/L PBTK NA 50% Rat Human -DTXSID1047491 Css NA 0.3431 mg/L PBTK NA 95% Rat Human -DTXSID1047493 Clint NA 1.038 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047493 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047493 Vd NA 2.807 L/kg 1compartment NA NA Human Human -DTXSID1047493 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1047493 TK.Half.Life NA 15.2 hours 1compartment NA NA Human Human -DTXSID1047493 Css NA 0.4615 mg/L 3compartmentss NA 50% Human Human -DTXSID1047493 Css NA 2.928 mg/L 3compartmentss NA 95% Human Human -DTXSID1047493 Css NA 0.4487 mg/L PBTK NA 50% Human Human -DTXSID1047493 Css NA 2.186 mg/L PBTK NA 95% Human Human -DTXSID1047493 Clint NA 1.038 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047493 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047493 Vd NA 2.318 L/kg 1compartment NA NA Rat Human -DTXSID1047493 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047493 TK.Half.Life NA 3.625 hours 1compartment NA NA Rat Human -DTXSID1047493 Css NA 0.1779 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047493 Css NA 0.9161 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047493 Css NA 0.1715 mg/L PBTK NA 50% Rat Human -DTXSID1047493 Css NA 0.6148 mg/L PBTK NA 95% Rat Human -DTXSID1047497 Clint NA 79.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047497 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047497 Vd NA 56.55 L/kg 1compartment NA NA Human Human -DTXSID1047497 Days.Css NA 102 Days PBTK NA NA Human Human -DTXSID1047497 TK.Half.Life NA 468.3 hours 1compartment NA NA Human Human -DTXSID1047497 Css NA 0.1089 mg/L 3compartmentss NA 50% Human Human -DTXSID1047497 Css NA 0.6647 mg/L 3compartmentss NA 95% Human Human -DTXSID1047497 Css NA 0.6853 mg/L PBTK NA 50% Human Human -DTXSID1047497 Css NA 3.876 mg/L PBTK NA 95% Human Human -DTXSID1047497 Clint NA 79.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047497 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047497 Vd NA 47.91 L/kg 1compartment NA NA Rat Human -DTXSID1047497 Days.Css NA 67 Days PBTK NA NA Rat Human -DTXSID1047497 TK.Half.Life NA 73.49 hours 1compartment NA NA Rat Human -DTXSID1047497 Css NA 0.05585 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047497 Css NA 0.2359 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047497 Css NA 0.3716 mg/L PBTK NA 50% Rat Human -DTXSID1047497 Css NA 1.575 mg/L PBTK NA 95% Rat Human +DTXSID1047491 TK.Half.Life NA 0.8758 hours 1compartment NA NA Rat Human +DTXSID1047491 Css NA 0.01688 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047491 Css NA 0.09028 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047491 Css NA 0.01329 mg/L PBTK NA 50% Rat Human +DTXSID1047491 Css NA 0.06008 mg/L PBTK NA 95% Rat Human +DTXSID1047493 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047493 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047493 Vd NA 2.239 L/kg 1compartment NA NA Human Human +DTXSID1047493 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID1047493 TK.Half.Life NA 48.07 hours 1compartment NA NA Human Human +DTXSID1047493 Css NA 2.063 mg/L 3compartmentss NA 50% Human Human +DTXSID1047493 Css NA 9.159 mg/L 3compartmentss NA 95% Human Human +DTXSID1047493 Css NA 1.759 mg/L PBTK NA 50% Human Human +DTXSID1047493 Css NA 6.267 mg/L PBTK NA 95% Human Human +DTXSID1047493 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047493 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047493 Vd NA 1.834 L/kg 1compartment NA NA Rat Human +DTXSID1047493 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1047493 TK.Half.Life NA 9.259 hours 1compartment NA NA Rat Human +DTXSID1047493 Css NA 0.1292 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047493 Css NA 0.4932 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047493 Css NA 0.1106 mg/L PBTK NA 50% Rat Human +DTXSID1047493 Css NA 0.3257 mg/L PBTK NA 95% Rat Human +DTXSID1047520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047520 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047520 Vd NA 2.939 L/kg 1compartment NA NA Human Human +DTXSID1047520 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1047520 TK.Half.Life NA 16.82 hours 1compartment NA NA Human Human +DTXSID1047520 Css NA 0.5827 mg/L 3compartmentss NA 50% Human Human +DTXSID1047520 Css NA 3.75 mg/L 3compartmentss NA 95% Human Human +DTXSID1047520 Css NA 0.4124 mg/L PBTK NA 50% Human Human +DTXSID1047520 Css NA 2.551 mg/L PBTK NA 95% Human Human +DTXSID1047520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047520 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047520 Vd NA 2.215 L/kg 1compartment NA NA Rat Human +DTXSID1047520 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1047520 TK.Half.Life NA 3.2 hours 1compartment NA NA Rat Human +DTXSID1047520 Css NA 0.07408 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047520 Css NA 0.3749 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047520 Css NA 0.05218 mg/L PBTK NA 50% Rat Human +DTXSID1047520 Css NA 0.2563 mg/L PBTK NA 95% Rat Human DTXSID1047524 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1047524 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047524 Vd NA 0.8904 L/kg 1compartment NA NA Human Human +DTXSID1047524 Vd NA 1.007 L/kg 1compartment NA NA Human Human DTXSID1047524 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047524 TK.Half.Life NA 5.762 hours 1compartment NA NA Human Human -DTXSID1047524 Css NA 0.8168 mg/L 3compartmentss NA 50% Human Human -DTXSID1047524 Css NA 5.51 mg/L 3compartmentss NA 95% Human Human -DTXSID1047524 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID1047524 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID1047524 TK.Half.Life NA 6.515 hours 1compartment NA NA Human Human +DTXSID1047524 Css NA 0.44 mg/L 3compartmentss NA 50% Human Human +DTXSID1047524 Css NA 3 mg/L 3compartmentss NA 95% Human Human +DTXSID1047524 Css NA 0.3839 mg/L PBTK NA 50% Human Human +DTXSID1047524 Css NA 2.013 mg/L PBTK NA 95% Human Human DTXSID1047524 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1047524 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047524 Vd NA 0.9346 L/kg 1compartment NA NA Rat Human +DTXSID1047524 Vd NA 1.04 L/kg 1compartment NA NA Rat Human DTXSID1047524 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047524 TK.Half.Life NA 2.06 hours 1compartment NA NA Rat Human -DTXSID1047524 Css NA 0.2047 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047524 Css NA 1.301 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047524 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID1047524 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID1047526 Clint NA 38.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047526 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047526 Vd NA 135 L/kg 1compartment NA NA Human Human -DTXSID1047526 Days.Css NA 584 Days PBTK NA NA Human Human -DTXSID1047526 TK.Half.Life NA 2269 hours 1compartment NA NA Human Human -DTXSID1047526 Css NA 0.08193 mg/L 3compartmentss NA 50% Human Human -DTXSID1047526 Css NA 0.4998 mg/L 3compartmentss NA 95% Human Human -DTXSID1047526 Css NA 1.397 mg/L PBTK NA 50% Human Human -DTXSID1047526 Css NA 7.85 mg/L PBTK NA 95% Human Human -DTXSID1047526 Clint NA 38.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047526 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047526 Vd NA 117.8 L/kg 1compartment NA NA Rat Human -DTXSID1047526 Days.Css NA 372 Days PBTK NA NA Rat Human -DTXSID1047526 TK.Half.Life NA 346.4 hours 1compartment NA NA Rat Human -DTXSID1047526 Css NA 0.04174 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047526 Css NA 0.1811 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047526 Css NA 0.7565 mg/L PBTK NA 50% Rat Human -DTXSID1047526 Css NA 3.199 mg/L PBTK NA 95% Rat Human -DTXSID1047528 Clint NA 10.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047528 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047528 Vd NA 3.093 L/kg 1compartment NA NA Human Human -DTXSID1047528 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID1047528 TK.Half.Life NA 171.4 hours 1compartment NA NA Human Human -DTXSID1047528 Css NA 6.872 mg/L 3compartmentss NA 50% Human Human -DTXSID1047528 Css NA 42.09 mg/L 3compartmentss NA 95% Human Human -DTXSID1047528 Css NA 4.74 mg/L PBTK NA 50% Human Human -DTXSID1047528 Css NA 28.4 mg/L PBTK NA 95% Human Human -DTXSID1047528 Clint NA 10.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047528 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047528 Vd NA 2.316 L/kg 1compartment NA NA Rat Human -DTXSID1047528 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID1047528 TK.Half.Life NA 23.44 hours 1compartment NA NA Rat Human -DTXSID1047528 Css NA 3.889 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047528 Css NA 19.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047528 Css NA 2.572 mg/L PBTK NA 50% Rat Human -DTXSID1047528 Css NA 12.3 mg/L PBTK NA 95% Rat Human -DTXSID1047570 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047570 Fup NA 0.3178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047570 Vd NA 2.745 L/kg 1compartment NA NA Human Human +DTXSID1047524 TK.Half.Life NA 2.294 hours 1compartment NA NA Rat Human +DTXSID1047524 Css NA 0.002178 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047524 Css NA 0.01577 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047524 Css NA 0.00187 mg/L PBTK NA 50% Rat Human +DTXSID1047524 Css NA 0.01021 mg/L PBTK NA 95% Rat Human +DTXSID1047528 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047528 Fup 0.0149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047528 Vd NA 3.115 L/kg 1compartment NA NA Human Human +DTXSID1047528 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID1047528 TK.Half.Life NA 92.31 hours 1compartment NA NA Human Human +DTXSID1047528 Css NA 3.451 mg/L 3compartmentss NA 50% Human Human +DTXSID1047528 Css NA 20.29 mg/L 3compartmentss NA 95% Human Human +DTXSID1047528 Css NA 2.383 mg/L PBTK NA 50% Human Human +DTXSID1047528 Css NA 14.01 mg/L PBTK NA 95% Human Human +DTXSID1047528 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047528 Fup 0.0149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047528 Vd NA 2.333 L/kg 1compartment NA NA Rat Human +DTXSID1047528 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID1047528 TK.Half.Life NA 12.5 hours 1compartment NA NA Rat Human +DTXSID1047528 Css NA 0.4548 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047528 Css NA 2.354 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047528 Css NA 0.3116 mg/L PBTK NA 50% Rat Human +DTXSID1047528 Css NA 1.602 mg/L PBTK NA 95% Rat Human +DTXSID1047570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047570 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047570 Vd NA 2.394 L/kg 1compartment NA NA Human Human DTXSID1047570 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047570 TK.Half.Life NA 11.36 hours 1compartment NA NA Human Human -DTXSID1047570 Css NA 0.4094 mg/L 3compartmentss NA 50% Human Human -DTXSID1047570 Css NA 2.311 mg/L 3compartmentss NA 95% Human Human -DTXSID1047570 Css NA 0.3036 mg/L PBTK NA 50% Human Human -DTXSID1047570 Css NA 1.634 mg/L PBTK NA 95% Human Human -DTXSID1047570 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047570 Fup NA 0.3178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047570 Vd NA 2.096 L/kg 1compartment NA NA Rat Human +DTXSID1047570 TK.Half.Life NA 4.78 hours 1compartment NA NA Human Human +DTXSID1047570 Css NA 0.1466 mg/L 3compartmentss NA 50% Human Human +DTXSID1047570 Css NA 0.9491 mg/L 3compartmentss NA 95% Human Human +DTXSID1047570 Css NA 0.1092 mg/L PBTK NA 50% Human Human +DTXSID1047570 Css NA 0.6657 mg/L PBTK NA 95% Human Human +DTXSID1047570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047570 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047570 Vd NA 1.842 L/kg 1compartment NA NA Rat Human DTXSID1047570 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047570 TK.Half.Life NA 2.63 hours 1compartment NA NA Rat Human -DTXSID1047570 Css NA 0.2152 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047570 Css NA 0.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047570 Css NA 0.1545 mg/L PBTK NA 50% Rat Human -DTXSID1047570 Css NA 0.6301 mg/L PBTK NA 95% Rat Human -DTXSID1047601 Clint NA 13.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047601 Fup NA 0.241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047601 Vd NA 2.564 L/kg 1compartment NA NA Human Human +DTXSID1047570 TK.Half.Life NA 1.433 hours 1compartment NA NA Rat Human +DTXSID1047570 Css NA 0.01854 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047570 Css NA 0.09175 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047570 Css NA 0.01384 mg/L PBTK NA 50% Rat Human +DTXSID1047570 Css NA 0.06526 mg/L PBTK NA 95% Rat Human +DTXSID1047601 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047601 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047601 Vd NA 1.479 L/kg 1compartment NA NA Human Human DTXSID1047601 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047601 TK.Half.Life NA 7.614 hours 1compartment NA NA Human Human -DTXSID1047601 Css NA 0.2652 mg/L 3compartmentss NA 50% Human Human -DTXSID1047601 Css NA 1.631 mg/L 3compartmentss NA 95% Human Human -DTXSID1047601 Css NA 0.203 mg/L PBTK NA 50% Human Human -DTXSID1047601 Css NA 1.184 mg/L PBTK NA 95% Human Human -DTXSID1047601 Clint NA 13.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047601 Fup NA 0.241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047601 Vd NA 2.028 L/kg 1compartment NA NA Rat Human +DTXSID1047601 TK.Half.Life NA 1.865 hours 1compartment NA NA Human Human +DTXSID1047601 Css NA 0.06399 mg/L 3compartmentss NA 50% Human Human +DTXSID1047601 Css NA 0.4818 mg/L 3compartmentss NA 95% Human Human +DTXSID1047601 Css NA 0.05072 mg/L PBTK NA 50% Human Human +DTXSID1047601 Css NA 0.3412 mg/L PBTK NA 95% Human Human +DTXSID1047601 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047601 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047601 Vd NA 1.304 L/kg 1compartment NA NA Rat Human DTXSID1047601 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047601 TK.Half.Life NA 2.287 hours 1compartment NA NA Rat Human -DTXSID1047601 Css NA 0.142 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047601 Css NA 0.6377 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047601 Css NA 0.1048 mg/L PBTK NA 50% Rat Human -DTXSID1047601 Css NA 0.4371 mg/L PBTK NA 95% Rat Human -DTXSID1047605 Clint NA 20.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047605 Fup NA 0.0244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047605 Vd NA 2.172 L/kg 1compartment NA NA Human Human -DTXSID1047605 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1047605 TK.Half.Life NA 21.25 hours 1compartment NA NA Human Human -DTXSID1047605 Css NA 1.446 mg/L 3compartmentss NA 50% Human Human -DTXSID1047605 Css NA 11.01 mg/L 3compartmentss NA 95% Human Human -DTXSID1047605 Css NA 0.9373 mg/L PBTK NA 50% Human Human -DTXSID1047605 Css NA 6.94 mg/L PBTK NA 95% Human Human -DTXSID1047605 Clint NA 20.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047605 Fup NA 0.0244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047605 Vd NA 1.618 L/kg 1compartment NA NA Rat Human +DTXSID1047601 TK.Half.Life NA 0.84 hours 1compartment NA NA Rat Human +DTXSID1047601 Css NA 0.007954 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047601 Css NA 0.04673 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047601 Css NA 0.006294 mg/L PBTK NA 50% Rat Human +DTXSID1047601 Css NA 0.03373 mg/L PBTK NA 95% Rat Human +DTXSID1047603 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047603 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047603 Vd NA 2.459 L/kg 1compartment NA NA Human Human +DTXSID1047603 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1047603 TK.Half.Life NA 8.278 hours 1compartment NA NA Human Human +DTXSID1047603 Css NA 0.3429 mg/L 3compartmentss NA 50% Human Human +DTXSID1047603 Css NA 2.346 mg/L 3compartmentss NA 95% Human Human +DTXSID1047603 Css NA 0.2393 mg/L PBTK NA 50% Human Human +DTXSID1047603 Css NA 1.546 mg/L PBTK NA 95% Human Human +DTXSID1047603 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047603 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047603 Vd NA 1.862 L/kg 1compartment NA NA Rat Human +DTXSID1047603 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1047603 TK.Half.Life NA 2.275 hours 1compartment NA NA Rat Human +DTXSID1047603 Css NA 0.04358 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047603 Css NA 0.2261 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047603 Css NA 0.03014 mg/L PBTK NA 50% Rat Human +DTXSID1047603 Css NA 0.1482 mg/L PBTK NA 95% Rat Human +DTXSID1047605 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047605 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047605 Vd NA 2.068 L/kg 1compartment NA NA Human Human +DTXSID1047605 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1047605 TK.Half.Life NA 30.54 hours 1compartment NA NA Human Human +DTXSID1047605 Css NA 2.243 mg/L 3compartmentss NA 50% Human Human +DTXSID1047605 Css NA 18.12 mg/L 3compartmentss NA 95% Human Human +DTXSID1047605 Css NA 1.432 mg/L PBTK NA 50% Human Human +DTXSID1047605 Css NA 11.18 mg/L PBTK NA 95% Human Human +DTXSID1047605 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047605 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047605 Vd NA 1.534 L/kg 1compartment NA NA Rat Human DTXSID1047605 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1047605 TK.Half.Life NA 6.33 hours 1compartment NA NA Rat Human -DTXSID1047605 Css NA 0.8013 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047605 Css NA 4.911 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047605 Css NA 0.4937 mg/L PBTK NA 50% Rat Human -DTXSID1047605 Css NA 2.882 mg/L PBTK NA 95% Rat Human -DTXSID1047609 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047609 Fup NA 0.5111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047609 Vd NA 1.726 L/kg 1compartment NA NA Human Human -DTXSID1047609 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1047609 TK.Half.Life NA 29.28 hours 1compartment NA NA Human Human -DTXSID1047609 Css NA 1.733 mg/L 3compartmentss NA 50% Human Human -DTXSID1047609 Css NA 8.504 mg/L 3compartmentss NA 95% Human Human -DTXSID1047609 Css NA 1.456 mg/L PBTK NA 50% Human Human -DTXSID1047609 Css NA 5.684 mg/L PBTK NA 95% Human Human -DTXSID1047609 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047609 Fup NA 0.5111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047609 Vd NA 1.429 L/kg 1compartment NA NA Rat Human +DTXSID1047605 TK.Half.Life NA 9.494 hours 1compartment NA NA Rat Human +DTXSID1047605 Css NA 0.29 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047605 Css NA 2.024 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047605 Css NA 0.1814 mg/L PBTK NA 50% Rat Human +DTXSID1047605 Css NA 1.202 mg/L PBTK NA 95% Rat Human +DTXSID1047607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047607 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047607 Vd NA 2.22 L/kg 1compartment NA NA Human Human +DTXSID1047607 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1047607 TK.Half.Life NA 9.72 hours 1compartment NA NA Human Human +DTXSID1047607 Css NA 0.5138 mg/L 3compartmentss NA 50% Human Human +DTXSID1047607 Css NA 3.42 mg/L 3compartmentss NA 95% Human Human +DTXSID1047607 Css NA 0.3468 mg/L PBTK NA 50% Human Human +DTXSID1047607 Css NA 2.214 mg/L PBTK NA 95% Human Human +DTXSID1047607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047607 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047607 Vd NA 1.671 L/kg 1compartment NA NA Rat Human +DTXSID1047607 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1047607 TK.Half.Life NA 2.92 hours 1compartment NA NA Rat Human +DTXSID1047607 Css NA 0.0664 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047607 Css NA 0.3563 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047607 Css NA 0.04409 mg/L PBTK NA 50% Rat Human +DTXSID1047607 Css NA 0.2256 mg/L PBTK NA 95% Rat Human +DTXSID1047609 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047609 Fup 0.498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047609 Vd NA 1.416 L/kg 1compartment NA NA Human Human +DTXSID1047609 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1047609 TK.Half.Life NA 1.422 hours 1compartment NA NA Human Human +DTXSID1047609 Css NA 0.04044 mg/L 3compartmentss NA 50% Human Human +DTXSID1047609 Css NA 0.367 mg/L 3compartmentss NA 95% Human Human +DTXSID1047609 Css NA 0.03348 mg/L PBTK NA 50% Human Human +DTXSID1047609 Css NA 0.2629 mg/L PBTK NA 95% Human Human +DTXSID1047609 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047609 Fup 0.498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047609 Vd NA 1.208 L/kg 1compartment NA NA Rat Human DTXSID1047609 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047609 TK.Half.Life NA 6.665 hours 1compartment NA NA Rat Human -DTXSID1047609 Css NA 0.4598 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047609 Css NA 1.99 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047609 Css NA 0.3754 mg/L PBTK NA 50% Rat Human -DTXSID1047609 Css NA 1.241 mg/L PBTK NA 95% Rat Human -DTXSID1047657 Clint NA 5.214 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047657 Fup NA 0.2389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047657 Vd NA 2.126 L/kg 1compartment NA NA Human Human -DTXSID1047657 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047657 TK.Half.Life NA 11.12 hours 1compartment NA NA Human Human -DTXSID1047657 Css NA 0.5428 mg/L 3compartmentss NA 50% Human Human -DTXSID1047657 Css NA 2.877 mg/L 3compartmentss NA 95% Human Human -DTXSID1047657 Css NA 0.4005 mg/L PBTK NA 50% Human Human -DTXSID1047657 Css NA 1.98 mg/L PBTK NA 95% Human Human -DTXSID1047657 Clint NA 5.214 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047657 Fup NA 0.2389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047657 Vd NA 1.644 L/kg 1compartment NA NA Rat Human -DTXSID1047657 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047657 TK.Half.Life NA 3.464 hours 1compartment NA NA Rat Human -DTXSID1047657 Css NA 0.2776 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047657 Css NA 1.052 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047657 Css NA 0.1972 mg/L PBTK NA 50% Rat Human -DTXSID1047657 Css NA 0.6905 mg/L PBTK NA 95% Rat Human -DTXSID1047730 Clint NA 12.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047730 Fup NA 0.1007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047730 Vd NA 3.002 L/kg 1compartment NA NA Human Human -DTXSID1047730 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID1047730 TK.Half.Life NA 48.81 hours 1compartment NA NA Human Human -DTXSID1047730 Css NA 1.995 mg/L 3compartmentss NA 50% Human Human -DTXSID1047730 Css NA 11.82 mg/L 3compartmentss NA 95% Human Human -DTXSID1047730 Css NA 1.39 mg/L PBTK NA 50% Human Human -DTXSID1047730 Css NA 7.889 mg/L PBTK NA 95% Human Human -DTXSID1047730 Clint NA 12.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047730 Fup NA 0.1007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047730 Vd NA 2.254 L/kg 1compartment NA NA Rat Human -DTXSID1047730 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID1047730 TK.Half.Life NA 7.859 hours 1compartment NA NA Rat Human -DTXSID1047730 Css NA 1.086 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047730 Css NA 5.224 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047730 Css NA 0.7236 mg/L PBTK NA 50% Rat Human -DTXSID1047730 Css NA 3.394 mg/L PBTK NA 95% Rat Human -DTXSID1047780 Clint NA 12.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047780 Fup NA 0.492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047780 Vd NA 3.387 L/kg 1compartment NA NA Human Human +DTXSID1047609 TK.Half.Life NA 0.5889 hours 1compartment NA NA Rat Human +DTXSID1047609 Css NA 0.004904 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047609 Css NA 0.03666 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047609 Css NA 0.004121 mg/L PBTK NA 50% Rat Human +DTXSID1047609 Css NA 0.02549 mg/L PBTK NA 95% Rat Human +DTXSID1047780 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047780 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047780 Vd NA 0.8131 L/kg 1compartment NA NA Human Human DTXSID1047780 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047780 TK.Half.Life NA 3.027 hours 1compartment NA NA Human Human -DTXSID1047780 Css NA 0.03842 mg/L 3compartmentss NA 50% Human Human -DTXSID1047780 Css NA 0.3793 mg/L 3compartmentss NA 95% Human Human -DTXSID1047780 Css NA 0.05011 mg/L PBTK NA 50% Human Human -DTXSID1047780 Css NA 0.3515 mg/L PBTK NA 95% Human Human -DTXSID1047780 Clint NA 12.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047780 Fup NA 0.492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047780 Vd NA 3.387 L/kg 1compartment NA NA Rat Human +DTXSID1047780 TK.Half.Life NA 0.8147 hours 1compartment NA NA Human Human +DTXSID1047780 Css NA 0.03901 mg/L 3compartmentss NA 50% Human Human +DTXSID1047780 Css NA 0.3599 mg/L 3compartmentss NA 95% Human Human +DTXSID1047780 Css NA 0.03082 mg/L PBTK NA 50% Human Human +DTXSID1047780 Css NA 0.2486 mg/L PBTK NA 95% Human Human +DTXSID1047780 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047780 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047780 Vd NA 0.8252 L/kg 1compartment NA NA Rat Human DTXSID1047780 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047780 TK.Half.Life NA 1.701 hours 1compartment NA NA Rat Human -DTXSID1047780 Css NA 0.01881 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047780 Css NA 0.1648 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047780 Css NA 0.0247 mg/L PBTK NA 50% Rat Human -DTXSID1047780 Css NA 0.1393 mg/L PBTK NA 95% Rat Human -DTXSID1047782 Clint NA 24.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047782 Fup NA 0.2228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047782 Vd NA 2.341 L/kg 1compartment NA NA Human Human +DTXSID1047780 TK.Half.Life NA 0.4216 hours 1compartment NA NA Rat Human +DTXSID1047780 Css NA 0.004735 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047780 Css NA 0.03515 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047780 Css NA 0.003779 mg/L PBTK NA 50% Rat Human +DTXSID1047780 Css NA 0.02404 mg/L PBTK NA 95% Rat Human +DTXSID1047782 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047782 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047782 Vd NA 2.566 L/kg 1compartment NA NA Human Human DTXSID1047782 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047782 TK.Half.Life NA 2.535 hours 1compartment NA NA Human Human -DTXSID1047782 Css NA 0.05025 mg/L 3compartmentss NA 50% Human Human -DTXSID1047782 Css NA 0.3881 mg/L 3compartmentss NA 95% Human Human -DTXSID1047782 Css NA 0.05047 mg/L PBTK NA 50% Human Human -DTXSID1047782 Css NA 0.3312 mg/L PBTK NA 95% Human Human -DTXSID1047782 Clint NA 24.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047782 Fup NA 0.2228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047782 Vd NA 2.322 L/kg 1compartment NA NA Rat Human +DTXSID1047782 TK.Half.Life NA 2.733 hours 1compartment NA NA Human Human +DTXSID1047782 Css NA 0.04508 mg/L 3compartmentss NA 50% Human Human +DTXSID1047782 Css NA 0.3907 mg/L 3compartmentss NA 95% Human Human +DTXSID1047782 Css NA 0.04775 mg/L PBTK NA 50% Human Human +DTXSID1047782 Css NA 0.3433 mg/L PBTK NA 95% Human Human +DTXSID1047782 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047782 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047782 Vd NA 2.551 L/kg 1compartment NA NA Rat Human DTXSID1047782 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047782 TK.Half.Life NA 1.407 hours 1compartment NA NA Rat Human -DTXSID1047782 Css NA 0.02688 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047782 Css NA 0.1679 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047782 Css NA 0.02662 mg/L PBTK NA 50% Rat Human -DTXSID1047782 Css NA 0.1366 mg/L PBTK NA 95% Rat Human -DTXSID1047784 Clint NA 64.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047784 Fup NA 0.0334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047784 Vd NA 1.605 L/kg 1compartment NA NA Human Human +DTXSID1047782 TK.Half.Life NA 1.531 hours 1compartment NA NA Rat Human +DTXSID1047782 Css NA 0.005587 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047782 Css NA 0.03653 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047782 Css NA 0.006174 mg/L PBTK NA 50% Rat Human +DTXSID1047782 Css NA 0.03257 mg/L PBTK NA 95% Rat Human +DTXSID1047784 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047784 Fup 0.0731 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047784 Vd NA 2.616 L/kg 1compartment NA NA Human Human DTXSID1047784 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047784 TK.Half.Life NA 3.847 hours 1compartment NA NA Human Human -DTXSID1047784 Css NA 0.2738 mg/L 3compartmentss NA 50% Human Human -DTXSID1047784 Css NA 2.256 mg/L 3compartmentss NA 95% Human Human -DTXSID1047784 Css NA 0.1785 mg/L PBTK NA 50% Human Human -DTXSID1047784 Css NA 1.385 mg/L PBTK NA 95% Human Human -DTXSID1047784 Clint NA 64.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047784 Fup NA 0.0334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047784 Vd NA 1.306 L/kg 1compartment NA NA Rat Human +DTXSID1047784 TK.Half.Life NA 10.15 hours 1compartment NA NA Human Human +DTXSID1047784 Css NA 0.4114 mg/L 3compartmentss NA 50% Human Human +DTXSID1047784 Css NA 3.059 mg/L 3compartmentss NA 95% Human Human +DTXSID1047784 Css NA 0.295 mg/L PBTK NA 50% Human Human +DTXSID1047784 Css NA 2.051 mg/L PBTK NA 95% Human Human +DTXSID1047784 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047784 Fup 0.0731 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047784 Vd NA 2.103 L/kg 1compartment NA NA Rat Human DTXSID1047784 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047784 TK.Half.Life NA 1.644 hours 1compartment NA NA Rat Human -DTXSID1047784 Css NA 0.157 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047784 Css NA 1.071 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047784 Css NA 0.0964 mg/L PBTK NA 50% Rat Human -DTXSID1047784 Css NA 0.63 mg/L PBTK NA 95% Rat Human -DTXSID1047786 Clint NA 226.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047786 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047786 Vd NA 0.3774 L/kg 1compartment NA NA Human Human +DTXSID1047784 TK.Half.Life NA 3.265 hours 1compartment NA NA Rat Human +DTXSID1047784 Css NA 0.05403 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047784 Css NA 0.3095 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047784 Css NA 0.03849 mg/L PBTK NA 50% Rat Human +DTXSID1047784 Css NA 0.2093 mg/L PBTK NA 95% Rat Human +DTXSID1047786 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047786 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047786 Vd NA 0.4539 L/kg 1compartment NA NA Human Human DTXSID1047786 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047786 TK.Half.Life NA 0.532 hours 1compartment NA NA Human Human -DTXSID1047786 Css NA 0.08691 mg/L 3compartmentss NA 50% Human Human -DTXSID1047786 Css NA 0.7269 mg/L 3compartmentss NA 95% Human Human -DTXSID1047786 Css NA 0.05212 mg/L PBTK NA 50% Human Human -DTXSID1047786 Css NA 0.4315 mg/L PBTK NA 95% Human Human -DTXSID1047786 Clint NA 226.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047786 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047786 Vd NA 0.3154 L/kg 1compartment NA NA Rat Human +DTXSID1047786 TK.Half.Life NA 1.465 hours 1compartment NA NA Human Human +DTXSID1047786 Css NA 0.3985 mg/L 3compartmentss NA 50% Human Human +DTXSID1047786 Css NA 2.98 mg/L 3compartmentss NA 95% Human Human +DTXSID1047786 Css NA 0.2504 mg/L PBTK NA 50% Human Human +DTXSID1047786 Css NA 1.807 mg/L PBTK NA 95% Human Human +DTXSID1047786 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047786 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047786 Vd NA 0.3993 L/kg 1compartment NA NA Rat Human DTXSID1047786 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047786 TK.Half.Life NA 0.2314 hours 1compartment NA NA Rat Human -DTXSID1047786 Css NA 0.05117 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047786 Css NA 0.3398 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047786 Css NA 0.02874 mg/L PBTK NA 50% Rat Human -DTXSID1047786 Css NA 0.1876 mg/L PBTK NA 95% Rat Human -DTXSID1047788 Clint NA 5.081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047788 Fup NA 0.6705 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047788 Vd NA 0.7287 L/kg 1compartment NA NA Human Human +DTXSID1047786 TK.Half.Life NA 0.7822 hours 1compartment NA NA Rat Human +DTXSID1047786 Css NA 0.05198 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047786 Css NA 0.3089 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047786 Css NA 0.03188 mg/L PBTK NA 50% Rat Human +DTXSID1047786 Css NA 0.183 mg/L PBTK NA 95% Rat Human +DTXSID1047788 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047788 Fup 0.523 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047788 Vd NA 0.7205 L/kg 1compartment NA NA Human Human DTXSID1047788 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047788 TK.Half.Life NA 1.124 hours 1compartment NA NA Human Human -DTXSID1047788 Css NA 0.129 mg/L 3compartmentss NA 50% Human Human -DTXSID1047788 Css NA 1.115 mg/L 3compartmentss NA 95% Human Human -DTXSID1047788 Css NA 0.1017 mg/L PBTK NA 50% Human Human -DTXSID1047788 Css NA 0.74 mg/L PBTK NA 95% Human Human -DTXSID1047788 Clint NA 5.081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047788 Fup NA 0.6705 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047788 Vd NA 0.7277 L/kg 1compartment NA NA Rat Human +DTXSID1047788 TK.Half.Life NA 1.2 hours 1compartment NA NA Human Human +DTXSID1047788 Css NA 0.06184 mg/L 3compartmentss NA 50% Human Human +DTXSID1047788 Css NA 0.5641 mg/L 3compartmentss NA 95% Human Human +DTXSID1047788 Css NA 0.04811 mg/L PBTK NA 50% Human Human +DTXSID1047788 Css NA 0.3845 mg/L PBTK NA 95% Human Human +DTXSID1047788 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047788 Fup 0.523 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047788 Vd NA 0.6985 L/kg 1compartment NA NA Rat Human DTXSID1047788 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047788 TK.Half.Life NA 0.6017 hours 1compartment NA NA Rat Human -DTXSID1047788 Css NA 0.06095 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047788 Css NA 0.4497 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047788 Css NA 0.04736 mg/L PBTK NA 50% Rat Human -DTXSID1047788 Css NA 0.2693 mg/L PBTK NA 95% Rat Human -DTXSID1047811 Clint NA 3.804 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047811 Fup NA 0.1372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047811 Vd NA 3.837 L/kg 1compartment NA NA Human Human -DTXSID1047811 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1047811 TK.Half.Life NA 27.19 hours 1compartment NA NA Human Human -DTXSID1047811 Css NA 0.6901 mg/L 3compartmentss NA 50% Human Human -DTXSID1047811 Css NA 4.253 mg/L 3compartmentss NA 95% Human Human -DTXSID1047811 Css NA 0.6168 mg/L PBTK NA 50% Human Human -DTXSID1047811 Css NA 3.414 mg/L PBTK NA 95% Human Human -DTXSID1047811 Clint NA 3.804 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047811 Fup NA 0.1372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047811 Vd NA 3.321 L/kg 1compartment NA NA Rat Human -DTXSID1047811 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1047811 TK.Half.Life NA 7.317 hours 1compartment NA NA Rat Human -DTXSID1047811 Css NA 0.3602 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047811 Css NA 1.742 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047811 Css NA 0.3152 mg/L PBTK NA 50% Rat Human -DTXSID1047811 Css NA 1.381 mg/L PBTK NA 95% Rat Human -DTXSID1047813 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047813 Fup NA 0.3233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047813 Vd NA 3.841 L/kg 1compartment NA NA Human Human +DTXSID1047788 TK.Half.Life NA 0.6319 hours 1compartment NA NA Rat Human +DTXSID1047788 Css NA 0.0005662 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047788 Css NA 0.004717 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047788 Css NA 0.0004272 mg/L PBTK NA 50% Rat Human +DTXSID1047788 Css NA 0.002951 mg/L PBTK NA 95% Rat Human +DTXSID1047811 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047811 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047811 Vd NA 1.099 L/kg 1compartment NA NA Human Human +DTXSID1047811 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1047811 TK.Half.Life NA 2.694 hours 1compartment NA NA Human Human +DTXSID1047811 Css NA 0.1755 mg/L 3compartmentss NA 50% Human Human +DTXSID1047811 Css NA 1.152 mg/L 3compartmentss NA 95% Human Human +DTXSID1047811 Css NA 0.137 mg/L PBTK NA 50% Human Human +DTXSID1047811 Css NA 0.7822 mg/L PBTK NA 95% Human Human +DTXSID1047811 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047811 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047811 Vd NA 1.105 L/kg 1compartment NA NA Rat Human +DTXSID1047811 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1047811 TK.Half.Life NA 1.561 hours 1compartment NA NA Rat Human +DTXSID1047811 Css NA 0.007586 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047811 Css NA 0.05795 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047811 Css NA 0.00599 mg/L PBTK NA 50% Rat Human +DTXSID1047811 Css NA 0.03902 mg/L PBTK NA 95% Rat Human +DTXSID1047813 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047813 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047813 Vd NA 4.749 L/kg 1compartment NA NA Human Human DTXSID1047813 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047813 TK.Half.Life NA 1.931 hours 1compartment NA NA Human Human -DTXSID1047813 Css NA 0.007861 mg/L 3compartmentss NA 50% Human Human -DTXSID1047813 Css NA 0.07402 mg/L 3compartmentss NA 95% Human Human -DTXSID1047813 Css NA 0.01049 mg/L PBTK NA 50% Human Human -DTXSID1047813 Css NA 0.07549 mg/L PBTK NA 95% Human Human -DTXSID1047813 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047813 Fup NA 0.3233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047813 Vd NA 3.861 L/kg 1compartment NA NA Rat Human +DTXSID1047813 TK.Half.Life NA 3.132 hours 1compartment NA NA Human Human +DTXSID1047813 Css NA 0.01806 mg/L 3compartmentss NA 50% Human Human +DTXSID1047813 Css NA 0.176 mg/L 3compartmentss NA 95% Human Human +DTXSID1047813 Css NA 0.02796 mg/L PBTK NA 50% Human Human +DTXSID1047813 Css NA 0.2045 mg/L PBTK NA 95% Human Human +DTXSID1047813 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047813 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047813 Vd NA 4.785 L/kg 1compartment NA NA Rat Human DTXSID1047813 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047813 TK.Half.Life NA 0.9545 hours 1compartment NA NA Rat Human -DTXSID1047813 Css NA 0.004086 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047813 Css NA 0.03413 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047813 Css NA 0.0056 mg/L PBTK NA 50% Rat Human -DTXSID1047813 Css NA 0.03323 mg/L PBTK NA 95% Rat Human -DTXSID1047815 Clint NA 57.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047815 Fup NA 0.3623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047815 Vd NA 3.649 L/kg 1compartment NA NA Human Human +DTXSID1047813 TK.Half.Life NA 1.735 hours 1compartment NA NA Rat Human +DTXSID1047813 Css NA 0.002146 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047813 Css NA 0.01712 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047813 Css NA 0.003581 mg/L PBTK NA 50% Rat Human +DTXSID1047813 Css NA 0.01965 mg/L PBTK NA 95% Rat Human +DTXSID1047815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047815 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047815 Vd NA 2.673 L/kg 1compartment NA NA Human Human DTXSID1047815 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047815 TK.Half.Life NA 2.097 hours 1compartment NA NA Human Human -DTXSID1047815 Css NA 0.01181 mg/L 3compartmentss NA 50% Human Human -DTXSID1047815 Css NA 0.1102 mg/L 3compartmentss NA 95% Human Human -DTXSID1047815 Css NA 0.01477 mg/L PBTK NA 50% Human Human -DTXSID1047815 Css NA 0.1063 mg/L PBTK NA 95% Human Human -DTXSID1047815 Clint NA 57.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047815 Fup NA 0.3623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047815 Vd NA 3.7 L/kg 1compartment NA NA Rat Human +DTXSID1047815 TK.Half.Life NA 2.566 hours 1compartment NA NA Human Human +DTXSID1047815 Css NA 0.0382 mg/L 3compartmentss NA 50% Human Human +DTXSID1047815 Css NA 0.324 mg/L 3compartmentss NA 95% Human Human +DTXSID1047815 Css NA 0.04014 mg/L PBTK NA 50% Human Human +DTXSID1047815 Css NA 0.2822 mg/L PBTK NA 95% Human Human +DTXSID1047815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047815 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047815 Vd NA 2.694 L/kg 1compartment NA NA Rat Human DTXSID1047815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047815 TK.Half.Life NA 1.066 hours 1compartment NA NA Rat Human -DTXSID1047815 Css NA 0.006024 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047815 Css NA 0.05106 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047815 Css NA 0.00757 mg/L PBTK NA 50% Rat Human -DTXSID1047815 Css NA 0.04569 mg/L PBTK NA 95% Rat Human -DTXSID1047817 Clint NA 1.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047817 Fup NA 0.1521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047817 Vd NA 1.911 L/kg 1compartment NA NA Human Human -DTXSID1047817 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1047817 TK.Half.Life NA 21.37 hours 1compartment NA NA Human Human -DTXSID1047817 Css NA 1.311 mg/L 3compartmentss NA 50% Human Human -DTXSID1047817 Css NA 7.718 mg/L 3compartmentss NA 95% Human Human -DTXSID1047817 Css NA 1.013 mg/L PBTK NA 50% Human Human -DTXSID1047817 Css NA 5.051 mg/L PBTK NA 95% Human Human -DTXSID1047817 Clint NA 1.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047817 Fup NA 0.1521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047817 Vd NA 1.735 L/kg 1compartment NA NA Rat Human -DTXSID1047817 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1047817 TK.Half.Life NA 9.667 hours 1compartment NA NA Rat Human -DTXSID1047817 Css NA 0.6043 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047817 Css NA 2.731 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047817 Css NA 0.4504 mg/L PBTK NA 50% Rat Human -DTXSID1047817 Css NA 1.678 mg/L PBTK NA 95% Rat Human -DTXSID1047819 Clint NA 11.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047819 Fup NA 0.0762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047819 Vd NA 1.351 L/kg 1compartment NA NA Human Human -DTXSID1047819 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047819 TK.Half.Life NA 3.827 hours 1compartment NA NA Human Human -DTXSID1047819 Css NA 0.3078 mg/L 3compartmentss NA 50% Human Human -DTXSID1047819 Css NA 2.695 mg/L 3compartmentss NA 95% Human Human -DTXSID1047819 Css NA 0.2368 mg/L PBTK NA 50% Human Human -DTXSID1047819 Css NA 1.818 mg/L PBTK NA 95% Human Human -DTXSID1047819 Clint NA 11.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047819 Fup NA 0.0762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047819 Vd NA 1.312 L/kg 1compartment NA NA Rat Human -DTXSID1047819 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047819 TK.Half.Life NA 2.3 hours 1compartment NA NA Rat Human -DTXSID1047819 Css NA 0.1732 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047819 Css NA 1.166 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047819 Css NA 0.1251 mg/L PBTK NA 50% Rat Human -DTXSID1047819 Css NA 0.7286 mg/L PBTK NA 95% Rat Human -DTXSID1047869 Clint NA 4858 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047869 Fup NA 0.7562 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047869 Vd NA 2.953 L/kg 1compartment NA NA Human Human +DTXSID1047815 TK.Half.Life NA 1.418 hours 1compartment NA NA Rat Human +DTXSID1047815 Css NA 0.004714 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047815 Css NA 0.03107 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047815 Css NA 0.005106 mg/L PBTK NA 50% Rat Human +DTXSID1047815 Css NA 0.02698 mg/L PBTK NA 95% Rat Human +DTXSID1047817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047817 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047817 Vd NA 1.899 L/kg 1compartment NA NA Human Human +DTXSID1047817 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1047817 TK.Half.Life NA 3.522 hours 1compartment NA NA Human Human +DTXSID1047817 Css NA 0.1453 mg/L 3compartmentss NA 50% Human Human +DTXSID1047817 Css NA 1.174 mg/L 3compartmentss NA 95% Human Human +DTXSID1047817 Css NA 0.1115 mg/L PBTK NA 50% Human Human +DTXSID1047817 Css NA 0.8054 mg/L PBTK NA 95% Human Human +DTXSID1047817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047817 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047817 Vd NA 1.727 L/kg 1compartment NA NA Rat Human +DTXSID1047817 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1047817 TK.Half.Life NA 1.723 hours 1compartment NA NA Rat Human +DTXSID1047817 Css NA 0.0186 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047817 Css NA 0.1131 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047817 Css NA 0.01414 mg/L PBTK NA 50% Rat Human +DTXSID1047817 Css NA 0.07661 mg/L PBTK NA 95% Rat Human +DTXSID1047819 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047819 Fup 0.0437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047819 Vd NA 2.973 L/kg 1compartment NA NA Human Human +DTXSID1047819 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1047819 TK.Half.Life NA 41.68 hours 1compartment NA NA Human Human +DTXSID1047819 Css NA 1.696 mg/L 3compartmentss NA 50% Human Human +DTXSID1047819 Css NA 10.79 mg/L 3compartmentss NA 95% Human Human +DTXSID1047819 Css NA 1.17 mg/L PBTK NA 50% Human Human +DTXSID1047819 Css NA 7.342 mg/L PBTK NA 95% Human Human +DTXSID1047819 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047819 Fup 0.0437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047819 Vd NA 2.228 L/kg 1compartment NA NA Rat Human +DTXSID1047819 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1047819 TK.Half.Life NA 6.988 hours 1compartment NA NA Rat Human +DTXSID1047819 Css NA 0.2204 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047819 Css NA 1.252 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047819 Css NA 0.1501 mg/L PBTK NA 50% Rat Human +DTXSID1047819 Css NA 0.8342 mg/L PBTK NA 95% Rat Human +DTXSID1047869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047869 Fup 0.0991 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1047869 Vd NA 1.621 L/kg 1compartment NA NA Human Human DTXSID1047869 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1047869 TK.Half.Life NA 2.049 hours 1compartment NA NA Human Human -DTXSID1047869 Css NA 0.000537 mg/L 3compartmentss NA 50% Human Human -DTXSID1047869 Css NA 0.003941 mg/L 3compartmentss NA 95% Human Human -DTXSID1047869 Css NA 0.0004274 mg/L PBTK NA 50% Human Human -DTXSID1047869 Css NA 0.00291 mg/L PBTK NA 95% Human Human -DTXSID1047869 Clint NA 4858 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047869 Fup NA 0.7562 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047869 Vd NA 2.284 L/kg 1compartment NA NA Rat Human +DTXSID1047869 TK.Half.Life NA 4.777 hours 1compartment NA NA Human Human +DTXSID1047869 Css NA 0.3226 mg/L 3compartmentss NA 50% Human Human +DTXSID1047869 Css NA 2.483 mg/L 3compartmentss NA 95% Human Human +DTXSID1047869 Css NA 0.2138 mg/L PBTK NA 50% Human Human +DTXSID1047869 Css NA 1.553 mg/L PBTK NA 95% Human Human +DTXSID1047869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047869 Fup 0.0991 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1047869 Vd NA 1.238 L/kg 1compartment NA NA Rat Human DTXSID1047869 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047869 TK.Half.Life NA 0.6697 hours 1compartment NA NA Rat Human -DTXSID1047869 Css NA 0.0002997 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047869 Css NA 0.001923 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047869 Css NA 0.0002312 mg/L PBTK NA 50% Rat Human -DTXSID1047869 Css NA 0.00136 mg/L PBTK NA 95% Rat Human -DTXSID1047940 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047940 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047940 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID1047940 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1047940 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID1047940 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID1047940 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID1047940 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID1047940 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID1047940 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047940 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047940 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID1047940 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047940 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID1047940 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047940 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047940 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID1047940 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID1047942 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047942 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047942 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID1047942 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1047942 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID1047942 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID1047942 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID1047942 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID1047942 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID1047942 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047942 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047942 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID1047942 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1047942 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID1047942 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047942 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047942 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID1047942 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID1047944 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047944 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1047944 Vd NA 478.8 L/kg 1compartment NA NA Human Human -DTXSID1047944 Days.Css NA 97 Days PBTK NA NA Human Human -DTXSID1047944 TK.Half.Life NA 455.4 hours 1compartment NA NA Human Human -DTXSID1047944 Css NA 0.001119 mg/L 3compartmentss NA 50% Human Human -DTXSID1047944 Css NA 0.00673 mg/L 3compartmentss NA 95% Human Human -DTXSID1047944 Css NA 0.07869 mg/L PBTK NA 50% Human Human -DTXSID1047944 Css NA 0.4336 mg/L PBTK NA 95% Human Human -DTXSID1047944 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047944 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1047944 Vd NA 432.2 L/kg 1compartment NA NA Rat Human -DTXSID1047944 Days.Css NA 70 Days PBTK NA NA Rat Human -DTXSID1047944 TK.Half.Life NA 76.25 hours 1compartment NA NA Rat Human -DTXSID1047944 Css NA 0.0005635 mg/L 3compartmentss NA 50% Rat Human -DTXSID1047944 Css NA 0.002513 mg/L 3compartmentss NA 95% Rat Human -DTXSID1047944 Css NA 0.04275 mg/L PBTK NA 50% Rat Human -DTXSID1047944 Css NA 0.1912 mg/L PBTK NA 95% Rat Human +DTXSID1047869 TK.Half.Life NA 1.794 hours 1compartment NA NA Rat Human +DTXSID1047869 Css NA 0.04112 mg/L 3compartmentss NA 50% Rat Human +DTXSID1047869 Css NA 0.2403 mg/L 3compartmentss NA 95% Rat Human +DTXSID1047869 Css NA 0.0269 mg/L PBTK NA 50% Rat Human +DTXSID1047869 Css NA 0.1508 mg/L PBTK NA 95% Rat Human DTXSID1048122 Clint 63.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1048122 Fup 0.0104 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID1048122 Vd NA 0.7837 L/kg 1compartment NA NA Human Human DTXSID1048122 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1048122 TK.Half.Life NA 4.584 hours 1compartment NA NA Human Human -DTXSID1048122 Css NA 0.5403 mg/L 3compartmentss NA 50% Human Human -DTXSID1048122 Css NA 4.079 mg/L 3compartmentss NA 95% Human Human -DTXSID1048122 Css NA 0.33 mg/L PBTK NA 50% Human Human -DTXSID1048122 Css NA 2.472 mg/L PBTK NA 95% Human Human +DTXSID1048122 Css NA 0.4502 mg/L 3compartmentss NA 50% Human Human +DTXSID1048122 Css NA 3.608 mg/L 3compartmentss NA 95% Human Human +DTXSID1048122 Css NA 0.2749 mg/L PBTK NA 50% Human Human +DTXSID1048122 Css NA 2.174 mg/L PBTK NA 95% Human Human DTXSID1048122 Clint 63.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1048122 Fup 0.0104 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID1048122 Vd NA 0.5828 L/kg 1compartment NA NA Rat Human DTXSID1048122 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1048122 TK.Half.Life NA 2.08 hours 1compartment NA NA Rat Human -DTXSID1048122 Css NA 0.31 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048122 Css NA 1.846 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048122 Css NA 0.1769 mg/L PBTK NA 50% Rat Human -DTXSID1048122 Css NA 1.029 mg/L PBTK NA 95% Rat Human -DTXSID1048170 Clint NA 9.127 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048170 Fup NA 0.0026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048170 Vd NA 5.497 L/kg 1compartment NA NA Human Human -DTXSID1048170 Days.Css NA 88 Days PBTK NA NA Human Human -DTXSID1048170 TK.Half.Life NA 397.7 hours 1compartment NA NA Human Human -DTXSID1048170 Css NA 7.614 mg/L 3compartmentss NA 50% Human Human -DTXSID1048170 Css NA 46.27 mg/L 3compartmentss NA 95% Human Human -DTXSID1048170 Css NA 6.304 mg/L PBTK NA 50% Human Human -DTXSID1048170 Css NA 37.4 mg/L PBTK NA 95% Human Human -DTXSID1048170 Clint NA 9.127 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048170 Fup NA 0.0026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048170 Vd NA 4.214 L/kg 1compartment NA NA Rat Human -DTXSID1048170 Days.Css NA 50 Days PBTK NA NA Rat Human -DTXSID1048170 TK.Half.Life NA 63.19 hours 1compartment NA NA Rat Human -DTXSID1048170 Css NA 4.238 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048170 Css NA 19.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048170 Css NA 3.435 mg/L PBTK NA 50% Rat Human -DTXSID1048170 Css NA 15.32 mg/L PBTK NA 95% Rat Human -DTXSID1048172 Clint NA 48.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048172 Fup NA 0.0407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048172 Vd NA 0.2461 L/kg 1compartment NA NA Human Human +DTXSID1048122 Css NA 0.01761 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048122 Css NA 0.1534 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048122 Css NA 0.0102 mg/L PBTK NA 50% Rat Human +DTXSID1048122 Css NA 0.08729 mg/L PBTK NA 95% Rat Human +DTXSID1048170 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048170 Fup 0.00833 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048170 Vd NA 5.598 L/kg 1compartment NA NA Human Human +DTXSID1048170 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID1048170 TK.Half.Life NA 164.4 hours 1compartment NA NA Human Human +DTXSID1048170 Css NA 2.89 mg/L 3compartmentss NA 50% Human Human +DTXSID1048170 Css NA 18.59 mg/L 3compartmentss NA 95% Human Human +DTXSID1048170 Css NA 2.436 mg/L PBTK NA 50% Human Human +DTXSID1048170 Css NA 15.15 mg/L PBTK NA 95% Human Human +DTXSID1048170 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048170 Fup 0.00833 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048170 Vd NA 4.296 L/kg 1compartment NA NA Rat Human +DTXSID1048170 Days.Css NA 18 Days PBTK NA NA Rat Human +DTXSID1048170 TK.Half.Life NA 23.41 hours 1compartment NA NA Rat Human +DTXSID1048170 Css NA 0.3696 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048170 Css NA 1.911 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048170 Css NA 0.3158 mg/L PBTK NA 50% Rat Human +DTXSID1048170 Css NA 1.647 mg/L PBTK NA 95% Rat Human +DTXSID1048172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048172 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048172 Vd NA 0.4984 L/kg 1compartment NA NA Human Human DTXSID1048172 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048172 TK.Half.Life NA 0.7069 hours 1compartment NA NA Human Human -DTXSID1048172 Css NA 0.3746 mg/L 3compartmentss NA 50% Human Human -DTXSID1048172 Css NA 3.742 mg/L 3compartmentss NA 95% Human Human -DTXSID1048172 Css NA 0.2218 mg/L PBTK NA 50% Human Human -DTXSID1048172 Css NA 2.199 mg/L PBTK NA 95% Human Human -DTXSID1048172 Clint NA 48.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048172 Fup NA 0.0407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048172 Vd NA 0.2436 L/kg 1compartment NA NA Rat Human +DTXSID1048172 TK.Half.Life NA 0.8091 hours 1compartment NA NA Human Human +DTXSID1048172 Css NA 0.103 mg/L 3compartmentss NA 50% Human Human +DTXSID1048172 Css NA 0.7767 mg/L 3compartmentss NA 95% Human Human +DTXSID1048172 Css NA 0.06901 mg/L PBTK NA 50% Human Human +DTXSID1048172 Css NA 0.4917 mg/L PBTK NA 95% Human Human +DTXSID1048172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048172 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048172 Vd NA 0.4992 L/kg 1compartment NA NA Rat Human DTXSID1048172 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048172 TK.Half.Life NA 0.4245 hours 1compartment NA NA Rat Human -DTXSID1048172 Css NA 0.2164 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048172 Css NA 1.626 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048172 Css NA 0.1202 mg/L PBTK NA 50% Rat Human -DTXSID1048172 Css NA 0.8875 mg/L PBTK NA 95% Rat Human -DTXSID1048174 Clint NA 17.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048174 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048174 Vd NA 2.358 L/kg 1compartment NA NA Human Human -DTXSID1048174 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID1048174 TK.Half.Life NA 41.86 hours 1compartment NA NA Human Human -DTXSID1048174 Css NA 2.66 mg/L 3compartmentss NA 50% Human Human -DTXSID1048174 Css NA 20.08 mg/L 3compartmentss NA 95% Human Human -DTXSID1048174 Css NA 1.728 mg/L PBTK NA 50% Human Human -DTXSID1048174 Css NA 12.46 mg/L PBTK NA 95% Human Human -DTXSID1048174 Clint NA 17.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048174 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048174 Vd NA 1.754 L/kg 1compartment NA NA Rat Human -DTXSID1048174 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID1048174 TK.Half.Life NA 11.14 hours 1compartment NA NA Rat Human -DTXSID1048174 Css NA 1.485 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048174 Css NA 9.025 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048174 Css NA 0.9188 mg/L PBTK NA 50% Rat Human -DTXSID1048174 Css NA 5.346 mg/L PBTK NA 95% Rat Human -DTXSID1048178 Clint NA 1.295 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048178 Fup NA 0.0065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048178 Vd NA 0.5327 L/kg 1compartment NA NA Human Human -DTXSID1048178 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID1048178 TK.Half.Life NA 148.9 hours 1compartment NA NA Human Human -DTXSID1048178 Css NA 49.65 mg/L 3compartmentss NA 50% Human Human -DTXSID1048178 Css NA 351.8 mg/L 3compartmentss NA 95% Human Human -DTXSID1048178 Css NA 29.34 mg/L PBTK NA 50% Human Human -DTXSID1048178 Css NA 204.8 mg/L PBTK NA 95% Human Human -DTXSID1048178 Clint NA 1.295 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048178 Fup NA 0.0065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048178 Vd NA 0.4008 L/kg 1compartment NA NA Rat Human -DTXSID1048178 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID1048178 TK.Half.Life NA 59.04 hours 1compartment NA NA Rat Human -DTXSID1048178 Css NA 22.66 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048178 Css NA 134 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048178 Css NA 12.45 mg/L PBTK NA 50% Rat Human -DTXSID1048178 Css NA 72.6 mg/L PBTK NA 95% Rat Human -DTXSID1048201 Clint NA 6.247 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048201 Fup NA 0.2333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048201 Vd NA 2.176 L/kg 1compartment NA NA Human Human +DTXSID1048172 TK.Half.Life NA 0.4469 hours 1compartment NA NA Rat Human +DTXSID1048172 Css NA 0.0133 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048172 Css NA 0.07099 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048172 Css NA 0.008718 mg/L PBTK NA 50% Rat Human +DTXSID1048172 Css NA 0.04352 mg/L PBTK NA 95% Rat Human +DTXSID1048174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048174 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048174 Vd NA 1.625 L/kg 1compartment NA NA Human Human +DTXSID1048174 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1048174 TK.Half.Life NA 22.61 hours 1compartment NA NA Human Human +DTXSID1048174 Css NA 2.224 mg/L 3compartmentss NA 50% Human Human +DTXSID1048174 Css NA 19.06 mg/L 3compartmentss NA 95% Human Human +DTXSID1048174 Css NA 1.382 mg/L PBTK NA 50% Human Human +DTXSID1048174 Css NA 11.55 mg/L PBTK NA 95% Human Human +DTXSID1048174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048174 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048174 Vd NA 1.2 L/kg 1compartment NA NA Rat Human +DTXSID1048174 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1048174 TK.Half.Life NA 8.348 hours 1compartment NA NA Rat Human +DTXSID1048174 Css NA 0.2888 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048174 Css NA 2.121 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048174 Css NA 0.1752 mg/L PBTK NA 50% Rat Human +DTXSID1048174 Css NA 1.258 mg/L PBTK NA 95% Rat Human +DTXSID1048176 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048176 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048176 Vd NA 0.3234 L/kg 1compartment NA NA Human Human +DTXSID1048176 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1048176 TK.Half.Life NA 0.5291 hours 1compartment NA NA Human Human +DTXSID1048176 Css NA 0.08905 mg/L 3compartmentss NA 50% Human Human +DTXSID1048176 Css NA 0.6654 mg/L 3compartmentss NA 95% Human Human +DTXSID1048176 Css NA 0.05759 mg/L PBTK NA 50% Human Human +DTXSID1048176 Css NA 0.4136 mg/L PBTK NA 95% Human Human +DTXSID1048176 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048176 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048176 Vd NA 0.3382 L/kg 1compartment NA NA Rat Human +DTXSID1048176 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1048176 TK.Half.Life NA 0.3035 hours 1compartment NA NA Rat Human +DTXSID1048176 Css NA 0.004389 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048176 Css NA 0.03365 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048176 Css NA 0.002788 mg/L PBTK NA 50% Rat Human +DTXSID1048176 Css NA 0.02015 mg/L PBTK NA 95% Rat Human +DTXSID1048178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048178 Fup 0.0324 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048178 Vd NA 1.014 L/kg 1compartment NA NA Human Human +DTXSID1048178 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1048178 TK.Half.Life NA 6.172 hours 1compartment NA NA Human Human +DTXSID1048178 Css NA 0.9328 mg/L 3compartmentss NA 50% Human Human +DTXSID1048178 Css NA 7.775 mg/L 3compartmentss NA 95% Human Human +DTXSID1048178 Css NA 0.5724 mg/L PBTK NA 50% Human Human +DTXSID1048178 Css NA 4.698 mg/L PBTK NA 95% Human Human +DTXSID1048178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048178 Fup 0.0324 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048178 Vd NA 0.7593 L/kg 1compartment NA NA Rat Human +DTXSID1048178 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1048178 TK.Half.Life NA 2.673 hours 1compartment NA NA Rat Human +DTXSID1048178 Css NA 0.12 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048178 Css NA 0.8789 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048178 Css NA 0.07161 mg/L PBTK NA 50% Rat Human +DTXSID1048178 Css NA 0.5093 mg/L PBTK NA 95% Rat Human +DTXSID1048201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048201 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048201 Vd NA 1.849 L/kg 1compartment NA NA Human Human DTXSID1048201 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048201 TK.Half.Life NA 10.41 hours 1compartment NA NA Human Human -DTXSID1048201 Css NA 0.5004 mg/L 3compartmentss NA 50% Human Human -DTXSID1048201 Css NA 2.624 mg/L 3compartmentss NA 95% Human Human -DTXSID1048201 Css NA 0.3666 mg/L PBTK NA 50% Human Human -DTXSID1048201 Css NA 1.818 mg/L PBTK NA 95% Human Human -DTXSID1048201 Clint NA 6.247 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048201 Fup NA 0.2333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048201 Vd NA 1.678 L/kg 1compartment NA NA Rat Human +DTXSID1048201 TK.Half.Life NA 4.466 hours 1compartment NA NA Human Human +DTXSID1048201 Css NA 0.2224 mg/L 3compartmentss NA 50% Human Human +DTXSID1048201 Css NA 1.646 mg/L 3compartmentss NA 95% Human Human +DTXSID1048201 Css NA 0.1536 mg/L PBTK NA 50% Human Human +DTXSID1048201 Css NA 1.072 mg/L PBTK NA 95% Human Human +DTXSID1048201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048201 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048201 Vd NA 1.418 L/kg 1compartment NA NA Rat Human DTXSID1048201 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048201 TK.Half.Life NA 3.2 hours 1compartment NA NA Rat Human -DTXSID1048201 Css NA 0.2548 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048201 Css NA 0.9736 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048201 Css NA 0.1808 mg/L PBTK NA 50% Rat Human -DTXSID1048201 Css NA 0.6472 mg/L PBTK NA 95% Rat Human -DTXSID1048203 Clint NA 9.652 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048203 Fup NA 0.1774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048203 Vd NA 1.476 L/kg 1compartment NA NA Human Human -DTXSID1048203 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048203 TK.Half.Life NA 4.807 hours 1compartment NA NA Human Human -DTXSID1048203 Css NA 0.3157 mg/L 3compartmentss NA 50% Human Human -DTXSID1048203 Css NA 1.976 mg/L 3compartmentss NA 95% Human Human -DTXSID1048203 Css NA 0.224 mg/L PBTK NA 50% Human Human -DTXSID1048203 Css NA 1.308 mg/L PBTK NA 95% Human Human -DTXSID1048203 Clint NA 9.652 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048203 Fup NA 0.1774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048203 Vd NA 1.158 L/kg 1compartment NA NA Rat Human -DTXSID1048203 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048203 TK.Half.Life NA 1.916 hours 1compartment NA NA Rat Human -DTXSID1048203 Css NA 0.1686 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048203 Css NA 0.7651 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048203 Css NA 0.1143 mg/L PBTK NA 50% Rat Human -DTXSID1048203 Css NA 0.4809 mg/L PBTK NA 95% Rat Human -DTXSID1048207 Clint NA 8.391 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048207 Fup NA 0.0267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048207 Vd NA 0.2085 L/kg 1compartment NA NA Human Human +DTXSID1048201 TK.Half.Life NA 1.579 hours 1compartment NA NA Rat Human +DTXSID1048201 Css NA 0.02882 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048201 Css NA 0.1608 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048201 Css NA 0.01968 mg/L PBTK NA 50% Rat Human +DTXSID1048201 Css NA 0.1049 mg/L PBTK NA 95% Rat Human +DTXSID1048203 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048203 Fup 0.0786 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048203 Vd NA 3.053 L/kg 1compartment NA NA Human Human +DTXSID1048203 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1048203 TK.Half.Life NA 42.01 hours 1compartment NA NA Human Human +DTXSID1048203 Css NA 1.599 mg/L 3compartmentss NA 50% Human Human +DTXSID1048203 Css NA 10.2 mg/L 3compartmentss NA 95% Human Human +DTXSID1048203 Css NA 1.117 mg/L PBTK NA 50% Human Human +DTXSID1048203 Css NA 6.832 mg/L PBTK NA 95% Human Human +DTXSID1048203 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048203 Fup 0.0786 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048203 Vd NA 2.29 L/kg 1compartment NA NA Rat Human +DTXSID1048203 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1048203 TK.Half.Life NA 6.46 hours 1compartment NA NA Rat Human +DTXSID1048203 Css NA 0.2064 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048203 Css NA 1.118 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048203 Css NA 0.1418 mg/L PBTK NA 50% Rat Human +DTXSID1048203 Css NA 0.7434 mg/L PBTK NA 95% Rat Human +DTXSID1048207 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048207 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048207 Vd NA 0.2845 L/kg 1compartment NA NA Human Human DTXSID1048207 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048207 TK.Half.Life NA 3.569 hours 1compartment NA NA Human Human -DTXSID1048207 Css NA 3.098 mg/L 3compartmentss NA 50% Human Human -DTXSID1048207 Css NA 27.57 mg/L 3compartmentss NA 95% Human Human -DTXSID1048207 Css NA 1.852 mg/L PBTK NA 50% Human Human -DTXSID1048207 Css NA 16.01 mg/L PBTK NA 95% Human Human -DTXSID1048207 Clint NA 8.391 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048207 Fup NA 0.0267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048207 Vd NA 0.2048 L/kg 1compartment NA NA Rat Human +DTXSID1048207 TK.Half.Life NA 0.7361 hours 1compartment NA NA Human Human +DTXSID1048207 Css NA 0.2866 mg/L 3compartmentss NA 50% Human Human +DTXSID1048207 Css NA 2.278 mg/L 3compartmentss NA 95% Human Human +DTXSID1048207 Css NA 0.1776 mg/L PBTK NA 50% Human Human +DTXSID1048207 Css NA 1.378 mg/L PBTK NA 95% Human Human +DTXSID1048207 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048207 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048207 Vd NA 0.2818 L/kg 1compartment NA NA Rat Human DTXSID1048207 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048207 TK.Half.Life NA 2.25 hours 1compartment NA NA Rat Human -DTXSID1048207 Css NA 1.668 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048207 Css NA 11.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048207 Css NA 0.92 mg/L PBTK NA 50% Rat Human -DTXSID1048207 Css NA 5.981 mg/L PBTK NA 95% Rat Human +DTXSID1048207 TK.Half.Life NA 0.4327 hours 1compartment NA NA Rat Human +DTXSID1048207 Css NA 0.03749 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048207 Css NA 0.2316 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048207 Css NA 0.02256 mg/L PBTK NA 50% Rat Human +DTXSID1048207 Css NA 0.1349 mg/L PBTK NA 95% Rat Human +DTXSID1048257 Clint 1 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID1048257 Fup 0.019 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1048257 Vd NA 0.974 L/kg 1compartment NA NA Human Human +DTXSID1048257 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID1048257 TK.Half.Life NA 109.4 hours 1compartment NA NA Human Human +DTXSID1048257 Css NA 18.42 mg/L 3compartmentss NA 50% Human Human +DTXSID1048257 Css NA 123.1 mg/L 3compartmentss NA 95% Human Human +DTXSID1048257 Css NA 11.48 mg/L PBTK NA 50% Human Human +DTXSID1048257 Css NA 72.18 mg/L PBTK NA 95% Human Human +DTXSID1048257 Clint 1 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID1048257 Fup 0.019 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1048257 Vd NA 0.8234 L/kg 1compartment NA NA Rat Human +DTXSID1048257 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID1048257 TK.Half.Life NA 46.18 hours 1compartment NA NA Rat Human +DTXSID1048257 Css NA 1.843 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048257 Css NA 10.61 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048257 Css NA 1.115 mg/L PBTK NA 50% Rat Human +DTXSID1048257 Css NA 6.02 mg/L PBTK NA 95% Rat Human DTXSID1048259 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1048259 Fup NA 0.5047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048259 Vd NA 0.8017 L/kg 1compartment NA NA Human Human -DTXSID1048259 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1048259 TK.Half.Life NA 10.28 hours 1compartment NA NA Human Human -DTXSID1048259 Css NA 1.39 mg/L 3compartmentss NA 50% Human Human -DTXSID1048259 Css NA 7.424 mg/L 3compartmentss NA 95% Human Human -DTXSID1048259 Css NA 1.107 mg/L PBTK NA 50% Human Human -DTXSID1048259 Css NA 4.836 mg/L PBTK NA 95% Human Human +DTXSID1048259 Vd NA 0.3894 L/kg 1compartment NA NA Human Human +DTXSID1048259 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1048259 TK.Half.Life NA 4.994 hours 1compartment NA NA Human Human +DTXSID1048259 Css NA 1.335 mg/L 3compartmentss NA 50% Human Human +DTXSID1048259 Css NA 6.677 mg/L 3compartmentss NA 95% Human Human +DTXSID1048259 Css NA 0.9338 mg/L PBTK NA 50% Human Human +DTXSID1048259 Css NA 4.098 mg/L PBTK NA 95% Human Human DTXSID1048259 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1048259 Fup NA 0.5047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048259 Vd NA 0.8144 L/kg 1compartment NA NA Rat Human +DTXSID1048259 Vd NA 0.4028 L/kg 1compartment NA NA Rat Human DTXSID1048259 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048259 TK.Half.Life NA 3.556 hours 1compartment NA NA Rat Human -DTXSID1048259 Css NA 0.3696 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048259 Css NA 1.836 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048259 Css NA 0.2842 mg/L PBTK NA 50% Rat Human -DTXSID1048259 Css NA 1.1 mg/L PBTK NA 95% Rat Human +DTXSID1048259 TK.Half.Life NA 1.759 hours 1compartment NA NA Rat Human +DTXSID1048259 Css NA 0.02497 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048259 Css NA 0.173 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048259 Css NA 0.01672 mg/L PBTK NA 50% Rat Human +DTXSID1048259 Css NA 0.1056 mg/L PBTK NA 95% Rat Human DTXSID1048384 Clint 14.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1048384 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1048384 Vd NA 1.799 L/kg 1compartment NA NA Human Human +DTXSID1048384 Vd NA 1.753 L/kg 1compartment NA NA Human Human DTXSID1048384 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID1048384 TK.Half.Life NA 60.17 hours 1compartment NA NA Human Human -DTXSID1048384 Css NA 5.644 mg/L 3compartmentss NA 50% Human Human -DTXSID1048384 Css NA 47.09 mg/L 3compartmentss NA 95% Human Human -DTXSID1048384 Css NA 3.534 mg/L PBTK NA 50% Human Human -DTXSID1048384 Css NA 28.06 mg/L PBTK NA 95% Human Human +DTXSID1048384 TK.Half.Life NA 58.74 hours 1compartment NA NA Human Human +DTXSID1048384 Css NA 4.914 mg/L 3compartmentss NA 50% Human Human +DTXSID1048384 Css NA 42.67 mg/L 3compartmentss NA 95% Human Human +DTXSID1048384 Css NA 3.053 mg/L PBTK NA 50% Human Human +DTXSID1048384 Css NA 26.07 mg/L PBTK NA 95% Human Human DTXSID1048384 Clint 14.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1048384 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1048384 Vd NA 1.327 L/kg 1compartment NA NA Rat Human +DTXSID1048384 Vd NA 1.292 L/kg 1compartment NA NA Rat Human DTXSID1048384 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1048384 TK.Half.Life NA 20.83 hours 1compartment NA NA Rat Human -DTXSID1048384 Css NA 3.178 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048384 Css NA 21.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048384 Css NA 1.871 mg/L PBTK NA 50% Rat Human -DTXSID1048384 Css NA 12.29 mg/L PBTK NA 95% Rat Human -DTXSID1048590 Clint NA 34.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048590 Fup NA 0.186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048590 Vd NA 0.4044 L/kg 1compartment NA NA Human Human +DTXSID1048384 TK.Half.Life NA 20.68 hours 1compartment NA NA Rat Human +DTXSID1048384 Css NA 0.243 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048384 Css NA 2.265 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048384 Css NA 0.1455 mg/L PBTK NA 50% Rat Human +DTXSID1048384 Css NA 1.324 mg/L PBTK NA 95% Rat Human +DTXSID1048542 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048542 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1048542 Vd NA 0.6605 L/kg 1compartment NA NA Human Human +DTXSID1048542 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1048542 TK.Half.Life NA 4.276 hours 1compartment NA NA Human Human +DTXSID1048542 Css NA 0.4715 mg/L 3compartmentss NA 50% Human Human +DTXSID1048542 Css NA 3.051 mg/L 3compartmentss NA 95% Human Human +DTXSID1048542 Css NA 0.3817 mg/L PBTK NA 50% Human Human +DTXSID1048542 Css NA 1.998 mg/L PBTK NA 95% Human Human +DTXSID1048542 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048542 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1048542 Vd NA 0.7114 L/kg 1compartment NA NA Rat Human +DTXSID1048542 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1048542 TK.Half.Life NA 1.569 hours 1compartment NA NA Rat Human +DTXSID1048542 Css NA 0.002362 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048542 Css NA 0.0173 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048542 Css NA 0.001866 mg/L PBTK NA 50% Rat Human +DTXSID1048542 Css NA 0.01062 mg/L PBTK NA 95% Rat Human +DTXSID1048548 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048548 Fup 0.453 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID1048548 Vd NA 3.137 L/kg 1compartment NA NA Human Human +DTXSID1048548 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID1048548 TK.Half.Life NA 59.6 hours 1compartment NA NA Human Human +DTXSID1048548 Css NA 1.287 mg/L 3compartmentss NA 50% Human Human +DTXSID1048548 Css NA 8.304 mg/L 3compartmentss NA 95% Human Human +DTXSID1048548 Css NA 1.544 mg/L PBTK NA 50% Human Human +DTXSID1048548 Css NA 9.964 mg/L PBTK NA 95% Human Human +DTXSID1048548 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048548 Fup 0.453 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID1048548 Vd NA 2.354 L/kg 1compartment NA NA Rat Human +DTXSID1048548 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID1048548 TK.Half.Life NA 7.86 hours 1compartment NA NA Rat Human +DTXSID1048548 Css NA 0.1607 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048548 Css NA 0.8227 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048548 Css NA 0.1996 mg/L PBTK NA 50% Rat Human +DTXSID1048548 Css NA 1.022 mg/L PBTK NA 95% Rat Human +DTXSID1048590 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048590 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048590 Vd NA 0.6307 L/kg 1compartment NA NA Human Human DTXSID1048590 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048590 TK.Half.Life NA 0.5762 hours 1compartment NA NA Human Human -DTXSID1048590 Css NA 0.07991 mg/L 3compartmentss NA 50% Human Human -DTXSID1048590 Css NA 0.556 mg/L 3compartmentss NA 95% Human Human -DTXSID1048590 Css NA 0.05148 mg/L PBTK NA 50% Human Human -DTXSID1048590 Css NA 0.3466 mg/L PBTK NA 95% Human Human -DTXSID1048590 Clint NA 34.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048590 Fup NA 0.186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048590 Vd NA 0.3779 L/kg 1compartment NA NA Rat Human +DTXSID1048590 TK.Half.Life NA 0.9178 hours 1compartment NA NA Human Human +DTXSID1048590 Css NA 0.07072 mg/L 3compartmentss NA 50% Human Human +DTXSID1048590 Css NA 0.5567 mg/L 3compartmentss NA 95% Human Human +DTXSID1048590 Css NA 0.04892 mg/L PBTK NA 50% Human Human +DTXSID1048590 Css NA 0.3582 mg/L PBTK NA 95% Human Human +DTXSID1048590 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048590 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048590 Vd NA 0.5551 L/kg 1compartment NA NA Rat Human DTXSID1048590 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048590 TK.Half.Life NA 0.2862 hours 1compartment NA NA Rat Human -DTXSID1048590 Css NA 0.04421 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048590 Css NA 0.2377 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048590 Css NA 0.02717 mg/L PBTK NA 50% Rat Human -DTXSID1048590 Css NA 0.1419 mg/L PBTK NA 95% Rat Human -DTXSID1048592 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048592 Fup NA 0.7945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048592 Vd NA 0.4913 L/kg 1compartment NA NA Human Human +DTXSID1048590 TK.Half.Life NA 0.4311 hours 1compartment NA NA Rat Human +DTXSID1048590 Css NA 0.003414 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048590 Css NA 0.02788 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048590 Css NA 0.002347 mg/L PBTK NA 50% Rat Human +DTXSID1048590 Css NA 0.01758 mg/L PBTK NA 95% Rat Human +DTXSID1048592 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048592 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048592 Vd NA 0.4803 L/kg 1compartment NA NA Human Human DTXSID1048592 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048592 TK.Half.Life NA 4.002 hours 1compartment NA NA Human Human -DTXSID1048592 Css NA 1.085 mg/L 3compartmentss NA 50% Human Human -DTXSID1048592 Css NA 6.064 mg/L 3compartmentss NA 95% Human Human -DTXSID1048592 Css NA 0.8116 mg/L PBTK NA 50% Human Human -DTXSID1048592 Css NA 3.809 mg/L PBTK NA 95% Human Human -DTXSID1048592 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048592 Fup NA 0.7945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048592 Vd NA 0.5082 L/kg 1compartment NA NA Rat Human +DTXSID1048592 TK.Half.Life NA 1.387 hours 1compartment NA NA Human Human +DTXSID1048592 Css NA 0.237 mg/L 3compartmentss NA 50% Human Human +DTXSID1048592 Css NA 1.502 mg/L 3compartmentss NA 95% Human Human +DTXSID1048592 Css NA 0.1609 mg/L PBTK NA 50% Human Human +DTXSID1048592 Css NA 0.9554 mg/L PBTK NA 95% Human Human +DTXSID1048592 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048592 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048592 Vd NA 0.4842 L/kg 1compartment NA NA Rat Human DTXSID1048592 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048592 TK.Half.Life NA 1.411 hours 1compartment NA NA Rat Human -DTXSID1048592 Css NA 0.2838 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048592 Css NA 1.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048592 Css NA 0.2032 mg/L PBTK NA 50% Rat Human -DTXSID1048592 Css NA 0.9255 mg/L PBTK NA 95% Rat Human -DTXSID1048594 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048594 Fup NA 0.3818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048594 Vd NA 0.3826 L/kg 1compartment NA NA Human Human +DTXSID1048592 TK.Half.Life NA 0.8065 hours 1compartment NA NA Rat Human +DTXSID1048592 Css NA 0.01036 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048592 Css NA 0.07406 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048592 Css NA 0.0069 mg/L PBTK NA 50% Rat Human +DTXSID1048592 Css NA 0.04655 mg/L PBTK NA 95% Rat Human +DTXSID1048594 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048594 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048594 Vd NA 0.3362 L/kg 1compartment NA NA Human Human DTXSID1048594 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048594 TK.Half.Life NA 6.484 hours 1compartment NA NA Human Human -DTXSID1048594 Css NA 2.032 mg/L 3compartmentss NA 50% Human Human -DTXSID1048594 Css NA 8.31 mg/L 3compartmentss NA 95% Human Human -DTXSID1048594 Css NA 1.408 mg/L PBTK NA 50% Human Human -DTXSID1048594 Css NA 5.18 mg/L PBTK NA 95% Human Human -DTXSID1048594 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048594 Fup NA 0.3818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048594 Vd NA 0.3973 L/kg 1compartment NA NA Rat Human +DTXSID1048594 TK.Half.Life NA 7.109 hours 1compartment NA NA Human Human +DTXSID1048594 Css NA 1.367 mg/L 3compartmentss NA 50% Human Human +DTXSID1048594 Css NA 5.889 mg/L 3compartmentss NA 95% Human Human +DTXSID1048594 Css NA 0.9224 mg/L PBTK NA 50% Human Human +DTXSID1048594 Css NA 3.6 mg/L PBTK NA 95% Human Human +DTXSID1048594 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048594 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048594 Vd NA 0.35 L/kg 1compartment NA NA Rat Human DTXSID1048594 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048594 TK.Half.Life NA 2.295 hours 1compartment NA NA Rat Human -DTXSID1048594 Css NA 0.5553 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048594 Css NA 1.944 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048594 Css NA 0.3665 mg/L PBTK NA 50% Rat Human -DTXSID1048594 Css NA 1.126 mg/L PBTK NA 95% Rat Human -DTXSID1048596 Clint NA 15.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1048594 TK.Half.Life NA 2.521 hours 1compartment NA NA Rat Human +DTXSID1048594 Css NA 0.007493 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048594 Css NA 0.03143 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048594 Css NA 0.00478 mg/L PBTK NA 50% Rat Human +DTXSID1048594 Css NA 0.01843 mg/L PBTK NA 95% Rat Human +DTXSID1048596 Clint 7 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID1048596 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1048596 Vd NA 0.2682 L/kg 1compartment NA NA Human Human -DTXSID1048596 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1048596 TK.Half.Life NA 14.46 hours 1compartment NA NA Human Human -DTXSID1048596 Css NA 10.18 mg/L 3compartmentss NA 50% Human Human -DTXSID1048596 Css NA 70.98 mg/L 3compartmentss NA 95% Human Human -DTXSID1048596 Css NA 5.98 mg/L PBTK NA 50% Human Human -DTXSID1048596 Css NA 41.05 mg/L PBTK NA 95% Human Human -DTXSID1048596 Clint NA 15.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1048596 Vd NA 0.1647 L/kg 1compartment NA NA Human Human +DTXSID1048596 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1048596 TK.Half.Life NA 21.28 hours 1compartment NA NA Human Human +DTXSID1048596 Css NA 21.14 mg/L 3compartmentss NA 50% Human Human +DTXSID1048596 Css NA 135.1 mg/L 3compartmentss NA 95% Human Human +DTXSID1048596 Css NA 12.24 mg/L PBTK NA 50% Human Human +DTXSID1048596 Css NA 77.14 mg/L PBTK NA 95% Human Human +DTXSID1048596 Clint 7 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID1048596 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1048596 Vd NA 0.2253 L/kg 1compartment NA NA Rat Human -DTXSID1048596 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048596 TK.Half.Life NA 8.137 hours 1compartment NA NA Rat Human -DTXSID1048596 Css NA 5.736 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048596 Css NA 29.51 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048596 Css NA 3.12 mg/L PBTK NA 50% Rat Human -DTXSID1048596 Css NA 16.01 mg/L PBTK NA 95% Rat Human -DTXSID1048598 Clint NA 53.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048598 Fup NA 0.028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048598 Vd NA 2.173 L/kg 1compartment NA NA Human Human -DTXSID1048598 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048598 TK.Half.Life NA 8.793 hours 1compartment NA NA Human Human -DTXSID1048598 Css NA 0.5172 mg/L 3compartmentss NA 50% Human Human -DTXSID1048598 Css NA 4.14 mg/L 3compartmentss NA 95% Human Human -DTXSID1048598 Css NA 0.336 mg/L PBTK NA 50% Human Human -DTXSID1048598 Css NA 2.613 mg/L PBTK NA 95% Human Human -DTXSID1048598 Clint NA 53.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048598 Fup NA 0.028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048598 Vd NA 1.621 L/kg 1compartment NA NA Rat Human -DTXSID1048598 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048598 TK.Half.Life NA 2.679 hours 1compartment NA NA Rat Human -DTXSID1048598 Css NA 0.2898 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048598 Css NA 1.874 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048598 Css NA 0.1781 mg/L PBTK NA 50% Rat Human -DTXSID1048598 Css NA 1.12 mg/L PBTK NA 95% Rat Human +DTXSID1048596 Vd NA 0.1626 L/kg 1compartment NA NA Rat Human +DTXSID1048596 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1048596 TK.Half.Life NA 13.57 hours 1compartment NA NA Rat Human +DTXSID1048596 Css NA 0.991 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048596 Css NA 6.64 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048596 Css NA 0.5455 mg/L PBTK NA 50% Rat Human +DTXSID1048596 Css NA 3.661 mg/L PBTK NA 95% Rat Human +DTXSID1048598 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048598 Fup 0.0646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048598 Vd NA 2.863 L/kg 1compartment NA NA Human Human +DTXSID1048598 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1048598 TK.Half.Life NA 26.03 hours 1compartment NA NA Human Human +DTXSID1048598 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human +DTXSID1048598 Css NA 6.769 mg/L 3compartmentss NA 95% Human Human +DTXSID1048598 Css NA 0.729 mg/L PBTK NA 50% Human Human +DTXSID1048598 Css NA 4.558 mg/L PBTK NA 95% Human Human +DTXSID1048598 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048598 Fup 0.0646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048598 Vd NA 2.149 L/kg 1compartment NA NA Rat Human +DTXSID1048598 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1048598 TK.Half.Life NA 5.016 hours 1compartment NA NA Rat Human +DTXSID1048598 Css NA 0.1382 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048598 Css NA 0.7331 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048598 Css NA 0.09364 mg/L PBTK NA 50% Rat Human +DTXSID1048598 Css NA 0.4859 mg/L PBTK NA 95% Rat Human DTXSID1048621 Clint NA 181 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1048621 Fup NA 0.1275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048621 Vd NA 0.2867 L/kg 1compartment NA NA Human Human +DTXSID1048621 Vd NA 0.2845 L/kg 1compartment NA NA Human Human DTXSID1048621 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048621 TK.Half.Life NA 0.2994 hours 1compartment NA NA Human Human -DTXSID1048621 Css NA 0.02532 mg/L 3compartmentss NA 50% Human Human -DTXSID1048621 Css NA 0.2177 mg/L 3compartmentss NA 95% Human Human -DTXSID1048621 Css NA 0.0157 mg/L PBTK NA 50% Human Human -DTXSID1048621 Css NA 0.1298 mg/L PBTK NA 95% Human Human +DTXSID1048621 TK.Half.Life NA 0.2967 hours 1compartment NA NA Human Human +DTXSID1048621 Css NA 0.01588 mg/L 3compartmentss NA 50% Human Human +DTXSID1048621 Css NA 0.1847 mg/L 3compartmentss NA 95% Human Human +DTXSID1048621 Css NA 0.009868 mg/L PBTK NA 50% Human Human +DTXSID1048621 Css NA 0.1129 mg/L PBTK NA 95% Human Human DTXSID1048621 Clint NA 181 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1048621 Fup NA 0.1275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048621 Vd NA 0.2932 L/kg 1compartment NA NA Rat Human +DTXSID1048621 Vd NA 0.2914 L/kg 1compartment NA NA Rat Human DTXSID1048621 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048621 TK.Half.Life NA 0.1446 hours 1compartment NA NA Rat Human -DTXSID1048621 Css NA 0.0145 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048621 Css NA 0.09726 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048621 Css NA 0.008459 mg/L PBTK NA 50% Rat Human -DTXSID1048621 Css NA 0.05515 mg/L PBTK NA 95% Rat Human -DTXSID1048623 Clint NA 426.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048623 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048623 Vd NA 5090 L/kg 1compartment NA NA Human Human -DTXSID1048623 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID1048623 TK.Half.Life NA 7744 hours 1compartment NA NA Human Human -DTXSID1048623 Css NA 0.0001417 mg/L 3compartmentss NA 50% Human Human -DTXSID1048623 Css NA 0.0008432 mg/L 3compartmentss NA 95% Human Human -DTXSID1048623 Css NA 0.1278 mg/L PBTK NA 50% Human Human -DTXSID1048623 Css NA 0.6875 mg/L PBTK NA 95% Human Human -DTXSID1048623 Clint NA 426.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048623 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048623 Vd NA 4761 L/kg 1compartment NA NA Rat Human -DTXSID1048623 Days.Css NA 1393 Days PBTK NA NA Rat Human -DTXSID1048623 TK.Half.Life NA 1311 hours 1compartment NA NA Rat Human -DTXSID1048623 Css NA 7.124e-05 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048623 Css NA 0.0003016 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048623 Css NA 0.06916 mg/L PBTK NA 50% Rat Human -DTXSID1048623 Css NA 0.2998 mg/L PBTK NA 95% Rat Human -DTXSID1048625 Clint NA 5.666 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048625 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048625 Vd NA 0.8075 L/kg 1compartment NA NA Human Human -DTXSID1048625 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1048625 TK.Half.Life NA 25.17 hours 1compartment NA NA Human Human -DTXSID1048625 Css NA 5.518 mg/L 3compartmentss NA 50% Human Human -DTXSID1048625 Css NA 47.14 mg/L 3compartmentss NA 95% Human Human -DTXSID1048625 Css NA 3.392 mg/L PBTK NA 50% Human Human -DTXSID1048625 Css NA 27.95 mg/L PBTK NA 95% Human Human -DTXSID1048625 Clint NA 5.666 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048625 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048625 Vd NA 0.6083 L/kg 1compartment NA NA Rat Human -DTXSID1048625 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1048625 TK.Half.Life NA 11.23 hours 1compartment NA NA Rat Human -DTXSID1048625 Css NA 2.915 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048625 Css NA 19.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048625 Css NA 1.662 mg/L PBTK NA 50% Rat Human -DTXSID1048625 Css NA 10.68 mg/L PBTK NA 95% Rat Human +DTXSID1048621 TK.Half.Life NA 0.1434 hours 1compartment NA NA Rat Human +DTXSID1048621 Css NA 0.0005996 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048621 Css NA 0.008069 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048621 Css NA 0.0003558 mg/L PBTK NA 50% Rat Human +DTXSID1048621 Css NA 0.004631 mg/L PBTK NA 95% Rat Human +DTXSID1048625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048625 Fup 0.0233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048625 Vd NA 0.3683 L/kg 1compartment NA NA Human Human +DTXSID1048625 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1048625 TK.Half.Life NA 2.962 hours 1compartment NA NA Human Human +DTXSID1048625 Css NA 1.322 mg/L 3compartmentss NA 50% Human Human +DTXSID1048625 Css NA 12.77 mg/L 3compartmentss NA 95% Human Human +DTXSID1048625 Css NA 0.7886 mg/L PBTK NA 50% Human Human +DTXSID1048625 Css NA 7.579 mg/L PBTK NA 95% Human Human +DTXSID1048625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048625 Fup 0.0233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048625 Vd NA 0.3051 L/kg 1compartment NA NA Rat Human +DTXSID1048625 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1048625 TK.Half.Life NA 1.585 hours 1compartment NA NA Rat Human +DTXSID1048625 Css NA 0.1744 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048625 Css NA 1.341 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048625 Css NA 0.1008 mg/L PBTK NA 50% Rat Human +DTXSID1048625 Css NA 0.7605 mg/L PBTK NA 95% Rat Human DTXSID1048627 Clint 8.567 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID1048627 Fup 0.015 NA NA https://doi.org/10.1124/dmd.117.077040 NA Human Human -DTXSID1048627 Vd NA 0.3799 L/kg 1compartment NA NA Human Human +DTXSID1048627 Vd NA 0.5688 L/kg 1compartment NA NA Human Human DTXSID1048627 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1048627 TK.Half.Life NA 10.34 hours 1compartment NA NA Human Human -DTXSID1048627 Css NA 4.849 mg/L 3compartmentss NA 50% Human Human -DTXSID1048627 Css NA 44.19 mg/L 3compartmentss NA 95% Human Human -DTXSID1048627 Css NA 2.933 mg/L PBTK NA 50% Human Human -DTXSID1048627 Css NA 26.21 mg/L PBTK NA 95% Human Human +DTXSID1048627 TK.Half.Life NA 15.03 hours 1compartment NA NA Human Human +DTXSID1048627 Css NA 4.648 mg/L 3compartmentss NA 50% Human Human +DTXSID1048627 Css NA 40.9 mg/L 3compartmentss NA 95% Human Human +DTXSID1048627 Css NA 2.742 mg/L PBTK NA 50% Human Human +DTXSID1048627 Css NA 24.13 mg/L PBTK NA 95% Human Human DTXSID1048627 Clint 1505 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID1048627 Fup 0.04 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID1048627 Vd NA 0.4686 L/kg 1compartment NA NA Rat Rat +DTXSID1048627 Vd NA 0.7056 L/kg 1compartment NA NA Rat Rat DTXSID1048627 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID1048627 TK.Half.Life NA 0.2123 hours 1compartment NA NA Rat Rat -DTXSID1048627 Css NA 0.006836 mg/L 3compartmentss NA 50% Rat Rat -DTXSID1048627 Css NA 0.05779 mg/L 3compartmentss NA 95% Rat Rat -DTXSID1048627 Css NA 0.003842 mg/L PBTK NA 50% Rat Rat -DTXSID1048627 Css NA 0.03184 mg/L PBTK NA 95% Rat Rat -DTXSID1048629 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048629 Fup NA 0.2064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048629 Vd NA 0.3443 L/kg 1compartment NA NA Human Human -DTXSID1048629 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1048629 TK.Half.Life NA 10.79 hours 1compartment NA NA Human Human -DTXSID1048629 Css NA 3.849 mg/L 3compartmentss NA 50% Human Human -DTXSID1048629 Css NA 14.2 mg/L 3compartmentss NA 95% Human Human -DTXSID1048629 Css NA 2.53 mg/L PBTK NA 50% Human Human -DTXSID1048629 Css NA 8.676 mg/L PBTK NA 95% Human Human -DTXSID1048629 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048629 Fup NA 0.2064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048629 Vd NA 0.3441 L/kg 1compartment NA NA Rat Human +DTXSID1048627 TK.Half.Life NA 0.3182 hours 1compartment NA NA Rat Rat +DTXSID1048627 Css NA 0.00108 mg/L 3compartmentss NA 50% Rat Rat +DTXSID1048627 Css NA 0.0109 mg/L 3compartmentss NA 95% Rat Rat +DTXSID1048627 Css NA 0.0006636 mg/L PBTK NA 50% Rat Rat +DTXSID1048627 Css NA 0.006655 mg/L PBTK NA 95% Rat Rat +DTXSID1048629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048629 Fup 0.511 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048629 Vd NA 0.5987 L/kg 1compartment NA NA Human Human +DTXSID1048629 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1048629 TK.Half.Life NA 0.5835 hours 1compartment NA NA Human Human +DTXSID1048629 Css NA 0.03735 mg/L 3compartmentss NA 50% Human Human +DTXSID1048629 Css NA 0.3347 mg/L 3compartmentss NA 95% Human Human +DTXSID1048629 Css NA 0.0293 mg/L PBTK NA 50% Human Human +DTXSID1048629 Css NA 0.2325 mg/L PBTK NA 95% Human Human +DTXSID1048629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048629 Fup 0.511 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048629 Vd NA 0.5991 L/kg 1compartment NA NA Rat Human DTXSID1048629 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048629 TK.Half.Life NA 3.675 hours 1compartment NA NA Rat Human -DTXSID1048629 Css NA 1.078 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048629 Css NA 3.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048629 Css NA 0.6712 mg/L PBTK NA 50% Rat Human -DTXSID1048629 Css NA 1.847 mg/L PBTK NA 95% Rat Human -DTXSID1048671 Clint NA 198 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048671 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048671 Vd NA 0.824 L/kg 1compartment NA NA Human Human +DTXSID1048629 TK.Half.Life NA 0.295 hours 1compartment NA NA Rat Human +DTXSID1048629 Css NA 0.004509 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048629 Css NA 0.03423 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048629 Css NA 0.003604 mg/L PBTK NA 50% Rat Human +DTXSID1048629 Css NA 0.02301 mg/L PBTK NA 95% Rat Human +DTXSID1048671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048671 Fup 0.0478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048671 Vd NA 1.576 L/kg 1compartment NA NA Human Human DTXSID1048671 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048671 TK.Half.Life NA 2.981 hours 1compartment NA NA Human Human -DTXSID1048671 Css NA 0.4962 mg/L 3compartmentss NA 50% Human Human -DTXSID1048671 Css NA 4.991 mg/L 3compartmentss NA 95% Human Human -DTXSID1048671 Css NA 0.2956 mg/L PBTK NA 50% Human Human -DTXSID1048671 Css NA 2.955 mg/L PBTK NA 95% Human Human -DTXSID1048671 Clint NA 198 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048671 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048671 Vd NA 0.6063 L/kg 1compartment NA NA Rat Human +DTXSID1048671 TK.Half.Life NA 7.786 hours 1compartment NA NA Human Human +DTXSID1048671 Css NA 0.6667 mg/L 3compartmentss NA 50% Human Human +DTXSID1048671 Css NA 5.038 mg/L 3compartmentss NA 95% Human Human +DTXSID1048671 Css NA 0.4264 mg/L PBTK NA 50% Human Human +DTXSID1048671 Css NA 3.102 mg/L PBTK NA 95% Human Human +DTXSID1048671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048671 Fup 0.0478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048671 Vd NA 1.181 L/kg 1compartment NA NA Rat Human DTXSID1048671 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048671 TK.Half.Life NA 1.288 hours 1compartment NA NA Rat Human -DTXSID1048671 Css NA 0.2944 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048671 Css NA 2.506 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048671 Css NA 0.1634 mg/L PBTK NA 50% Rat Human -DTXSID1048671 Css NA 1.367 mg/L PBTK NA 95% Rat Human +DTXSID1048671 TK.Half.Life NA 2.931 hours 1compartment NA NA Rat Human +DTXSID1048671 Css NA 0.08575 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048671 Css NA 0.5302 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048671 Css NA 0.0536 mg/L PBTK NA 50% Rat Human +DTXSID1048671 Css NA 0.321 mg/L PBTK NA 95% Rat Human DTXSID1048675 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1048675 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1048675 Vd NA 0.6057 L/kg 1compartment NA NA Human Human DTXSID1048675 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1048675 TK.Half.Life NA 4.63 hours 1compartment NA NA Human Human -DTXSID1048675 Css NA 0.9964 mg/L 3compartmentss NA 50% Human Human -DTXSID1048675 Css NA 5.933 mg/L 3compartmentss NA 95% Human Human -DTXSID1048675 Css NA 0.7897 mg/L PBTK NA 50% Human Human -DTXSID1048675 Css NA 3.798 mg/L PBTK NA 95% Human Human +DTXSID1048675 Css NA 0.8449 mg/L 3compartmentss NA 50% Human Human +DTXSID1048675 Css NA 5.012 mg/L 3compartmentss NA 95% Human Human +DTXSID1048675 Css NA 0.6738 mg/L PBTK NA 50% Human Human +DTXSID1048675 Css NA 3.19 mg/L PBTK NA 95% Human Human DTXSID1048675 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1048675 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1048675 Vd NA 0.6562 L/kg 1compartment NA NA Rat Human DTXSID1048675 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1048675 TK.Half.Life NA 1.71 hours 1compartment NA NA Rat Human -DTXSID1048675 Css NA 0.2553 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048675 Css NA 1.448 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048675 Css NA 0.1961 mg/L PBTK NA 50% Rat Human -DTXSID1048675 Css NA 0.8574 mg/L PBTK NA 95% Rat Human -DTXSID1048677 Clint NA 9.406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048677 Fup NA 0.2542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048677 Vd NA 0.622 L/kg 1compartment NA NA Human Human +DTXSID1048675 Css NA 0.01587 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048675 Css NA 0.1173 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048675 Css NA 0.01204 mg/L PBTK NA 50% Rat Human +DTXSID1048675 Css NA 0.07397 mg/L PBTK NA 95% Rat Human +DTXSID1048677 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048677 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048677 Vd NA 0.5041 L/kg 1compartment NA NA Human Human DTXSID1048677 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048677 TK.Half.Life NA 1.398 hours 1compartment NA NA Human Human -DTXSID1048677 Css NA 0.1964 mg/L 3compartmentss NA 50% Human Human -DTXSID1048677 Css NA 1.26 mg/L 3compartmentss NA 95% Human Human -DTXSID1048677 Css NA 0.1357 mg/L PBTK NA 50% Human Human -DTXSID1048677 Css NA 0.8173 mg/L PBTK NA 95% Human Human -DTXSID1048677 Clint NA 9.406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048677 Fup NA 0.2542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048677 Vd NA 0.5646 L/kg 1compartment NA NA Rat Human +DTXSID1048677 TK.Half.Life NA 6.614 hours 1compartment NA NA Human Human +DTXSID1048677 Css NA 0.7905 mg/L 3compartmentss NA 50% Human Human +DTXSID1048677 Css NA 4.355 mg/L 3compartmentss NA 95% Human Human +DTXSID1048677 Css NA 0.6041 mg/L PBTK NA 50% Human Human +DTXSID1048677 Css NA 2.732 mg/L PBTK NA 95% Human Human +DTXSID1048677 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048677 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048677 Vd NA 0.5125 L/kg 1compartment NA NA Rat Human DTXSID1048677 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048677 TK.Half.Life NA 0.7187 hours 1compartment NA NA Rat Human -DTXSID1048677 Css NA 0.1032 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048677 Css NA 0.4877 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048677 Css NA 0.06784 mg/L PBTK NA 50% Rat Human -DTXSID1048677 Css NA 0.2954 mg/L PBTK NA 95% Rat Human -DTXSID1048679 Clint NA 12.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048679 Fup NA 0.0477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048679 Vd NA 3.032 L/kg 1compartment NA NA Human Human -DTXSID1048679 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID1048679 TK.Half.Life NA 71.36 hours 1compartment NA NA Human Human -DTXSID1048679 Css NA 2.933 mg/L 3compartmentss NA 50% Human Human -DTXSID1048679 Css NA 18.31 mg/L 3compartmentss NA 95% Human Human -DTXSID1048679 Css NA 2.048 mg/L PBTK NA 50% Human Human -DTXSID1048679 Css NA 12.24 mg/L PBTK NA 95% Human Human -DTXSID1048679 Clint NA 12.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048679 Fup NA 0.0477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048679 Vd NA 2.285 L/kg 1compartment NA NA Rat Human -DTXSID1048679 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID1048679 TK.Half.Life NA 11.34 hours 1compartment NA NA Rat Human -DTXSID1048679 Css NA 1.64 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048679 Css NA 8.128 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048679 Css NA 1.086 mg/L PBTK NA 50% Rat Human -DTXSID1048679 Css NA 5.225 mg/L PBTK NA 95% Rat Human -DTXSID1048700 Clint NA 5.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048700 Fup NA 0.2962 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048700 Vd NA 4.996 L/kg 1compartment NA NA Human Human +DTXSID1048677 TK.Half.Life NA 2.292 hours 1compartment NA NA Rat Human +DTXSID1048677 Css NA 0.004231 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048677 Css NA 0.02389 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048677 Css NA 0.003068 mg/L PBTK NA 50% Rat Human +DTXSID1048677 Css NA 0.01481 mg/L PBTK NA 95% Rat Human +DTXSID1048679 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048679 Fup 0.0516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048679 Vd NA 3.04 L/kg 1compartment NA NA Human Human +DTXSID1048679 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1048679 TK.Half.Life NA 42.84 hours 1compartment NA NA Human Human +DTXSID1048679 Css NA 1.68 mg/L 3compartmentss NA 50% Human Human +DTXSID1048679 Css NA 10.61 mg/L 3compartmentss NA 95% Human Human +DTXSID1048679 Css NA 1.172 mg/L PBTK NA 50% Human Human +DTXSID1048679 Css NA 7.193 mg/L PBTK NA 95% Human Human +DTXSID1048679 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048679 Fup 0.0516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048679 Vd NA 2.29 L/kg 1compartment NA NA Rat Human +DTXSID1048679 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1048679 TK.Half.Life NA 6.965 hours 1compartment NA NA Rat Human +DTXSID1048679 Css NA 0.2149 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048679 Css NA 1.189 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048679 Css NA 0.1482 mg/L PBTK NA 50% Rat Human +DTXSID1048679 Css NA 0.807 mg/L PBTK NA 95% Rat Human +DTXSID1048700 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048700 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048700 Vd NA 1.086 L/kg 1compartment NA NA Human Human DTXSID1048700 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048700 TK.Half.Life NA 6.749 hours 1compartment NA NA Human Human -DTXSID1048700 Css NA 0.06679 mg/L 3compartmentss NA 50% Human Human -DTXSID1048700 Css NA 0.4739 mg/L 3compartmentss NA 95% Human Human -DTXSID1048700 Css NA 0.07731 mg/L PBTK NA 50% Human Human -DTXSID1048700 Css NA 0.4849 mg/L PBTK NA 95% Human Human -DTXSID1048700 Clint NA 5.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048700 Fup NA 0.2962 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048700 Vd NA 4.47 L/kg 1compartment NA NA Rat Human +DTXSID1048700 TK.Half.Life NA 3.593 hours 1compartment NA NA Human Human +DTXSID1048700 Css NA 0.298 mg/L 3compartmentss NA 50% Human Human +DTXSID1048700 Css NA 1.959 mg/L 3compartmentss NA 95% Human Human +DTXSID1048700 Css NA 0.2236 mg/L PBTK NA 50% Human Human +DTXSID1048700 Css NA 1.331 mg/L PBTK NA 95% Human Human +DTXSID1048700 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048700 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048700 Vd NA 1.076 L/kg 1compartment NA NA Rat Human DTXSID1048700 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048700 TK.Half.Life NA 1.819 hours 1compartment NA NA Rat Human -DTXSID1048700 Css NA 0.03571 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048700 Css NA 0.199 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048700 Css NA 0.04122 mg/L PBTK NA 50% Rat Human -DTXSID1048700 Css NA 0.2096 mg/L PBTK NA 95% Rat Human +DTXSID1048700 TK.Half.Life NA 2.107 hours 1compartment NA NA Rat Human +DTXSID1048700 Css NA 0.03557 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048700 Css NA 0.1603 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048700 Css NA 0.02666 mg/L PBTK NA 50% Rat Human +DTXSID1048700 Css NA 0.105 mg/L PBTK NA 95% Rat Human DTXSID1048704 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1048704 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048704 Vd NA 0.5442 L/kg 1compartment NA NA Human Human +DTXSID1048704 Vd NA 0.5389 L/kg 1compartment NA NA Human Human DTXSID1048704 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048704 TK.Half.Life NA 3.522 hours 1compartment NA NA Human Human -DTXSID1048704 Css NA 0.91 mg/L 3compartmentss NA 50% Human Human -DTXSID1048704 Css NA 5.667 mg/L 3compartmentss NA 95% Human Human -DTXSID1048704 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID1048704 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID1048704 TK.Half.Life NA 3.488 hours 1compartment NA NA Human Human +DTXSID1048704 Css NA 0.7688 mg/L 3compartmentss NA 50% Human Human +DTXSID1048704 Css NA 5.209 mg/L 3compartmentss NA 95% Human Human +DTXSID1048704 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID1048704 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID1048704 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1048704 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048704 Vd NA 0.5836 L/kg 1compartment NA NA Rat Human +DTXSID1048704 Vd NA 0.5792 L/kg 1compartment NA NA Rat Human DTXSID1048704 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048704 TK.Half.Life NA 1.287 hours 1compartment NA NA Rat Human -DTXSID1048704 Css NA 0.2307 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048704 Css NA 1.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048704 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID1048704 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID1048704 TK.Half.Life NA 1.277 hours 1compartment NA NA Rat Human +DTXSID1048704 Css NA 0.0142 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048704 Css NA 0.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048704 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID1048704 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID1048706 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1048706 Fup NA 0.7842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048706 Vd NA 0.685 L/kg 1compartment NA NA Human Human +DTXSID1048706 Vd NA 0.684 L/kg 1compartment NA NA Human Human DTXSID1048706 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048706 TK.Half.Life NA 5.649 hours 1compartment NA NA Human Human -DTXSID1048706 Css NA 1.007 mg/L 3compartmentss NA 50% Human Human -DTXSID1048706 Css NA 5.977 mg/L 3compartmentss NA 95% Human Human -DTXSID1048706 Css NA 0.828 mg/L PBTK NA 50% Human Human -DTXSID1048706 Css NA 3.892 mg/L PBTK NA 95% Human Human +DTXSID1048706 TK.Half.Life NA 5.645 hours 1compartment NA NA Human Human +DTXSID1048706 Css NA 0.8549 mg/L 3compartmentss NA 50% Human Human +DTXSID1048706 Css NA 5.374 mg/L 3compartmentss NA 95% Human Human +DTXSID1048706 Css NA 0.7028 mg/L PBTK NA 50% Human Human +DTXSID1048706 Css NA 3.437 mg/L PBTK NA 95% Human Human DTXSID1048706 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1048706 Fup NA 0.7842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048706 Vd NA 0.7117 L/kg 1compartment NA NA Rat Human +DTXSID1048706 Vd NA 0.7104 L/kg 1compartment NA NA Rat Human DTXSID1048706 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048706 TK.Half.Life NA 2.001 hours 1compartment NA NA Rat Human -DTXSID1048706 Css NA 0.2575 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048706 Css NA 1.633 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048706 Css NA 0.2046 mg/L PBTK NA 50% Rat Human -DTXSID1048706 Css NA 0.9695 mg/L PBTK NA 95% Rat Human -DTXSID1048708 Clint NA 10.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048708 Fup NA 0.0583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048708 Vd NA 2.978 L/kg 1compartment NA NA Human Human -DTXSID1048708 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID1048708 TK.Half.Life NA 73.9 hours 1compartment NA NA Human Human -DTXSID1048708 Css NA 3.122 mg/L 3compartmentss NA 50% Human Human -DTXSID1048708 Css NA 18.87 mg/L 3compartmentss NA 95% Human Human -DTXSID1048708 Css NA 2.16 mg/L PBTK NA 50% Human Human -DTXSID1048708 Css NA 12.59 mg/L PBTK NA 95% Human Human -DTXSID1048708 Clint NA 10.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048708 Fup NA 0.0583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048708 Vd NA 2.234 L/kg 1compartment NA NA Rat Human -DTXSID1048708 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID1048708 TK.Half.Life NA 11.96 hours 1compartment NA NA Rat Human -DTXSID1048708 Css NA 1.727 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048708 Css NA 8.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048708 Css NA 1.139 mg/L PBTK NA 50% Rat Human -DTXSID1048708 Css NA 5.098 mg/L PBTK NA 95% Rat Human -DTXSID1048750 Clint NA 8.869 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048750 Fup NA 0.822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048750 Vd NA 1.344 L/kg 1compartment NA NA Human Human -DTXSID1048750 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048750 TK.Half.Life NA 1.28 hours 1compartment NA NA Human Human -DTXSID1048750 Css NA 0.05962 mg/L 3compartmentss NA 50% Human Human -DTXSID1048750 Css NA 0.5398 mg/L 3compartmentss NA 95% Human Human -DTXSID1048750 Css NA 0.0541 mg/L PBTK NA 50% Human Human -DTXSID1048750 Css NA 0.401 mg/L PBTK NA 95% Human Human -DTXSID1048750 Clint NA 8.869 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048750 Fup NA 0.822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048750 Vd NA 1.378 L/kg 1compartment NA NA Rat Human +DTXSID1048706 TK.Half.Life NA 1.998 hours 1compartment NA NA Rat Human +DTXSID1048706 Css NA 0.01595 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048706 Css NA 0.1251 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048706 Css NA 0.01256 mg/L PBTK NA 50% Rat Human +DTXSID1048706 Css NA 0.08029 mg/L PBTK NA 95% Rat Human +DTXSID1048708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048708 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048708 Vd NA 2.855 L/kg 1compartment NA NA Human Human +DTXSID1048708 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1048708 TK.Half.Life NA 12.04 hours 1compartment NA NA Human Human +DTXSID1048708 Css NA 0.4134 mg/L 3compartmentss NA 50% Human Human +DTXSID1048708 Css NA 2.725 mg/L 3compartmentss NA 95% Human Human +DTXSID1048708 Css NA 0.2973 mg/L PBTK NA 50% Human Human +DTXSID1048708 Css NA 1.893 mg/L PBTK NA 95% Human Human +DTXSID1048708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048708 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048708 Vd NA 2.181 L/kg 1compartment NA NA Rat Human +DTXSID1048708 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1048708 TK.Half.Life NA 2.72 hours 1compartment NA NA Rat Human +DTXSID1048708 Css NA 0.0528 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048708 Css NA 0.2679 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048708 Css NA 0.03782 mg/L PBTK NA 50% Rat Human +DTXSID1048708 Css NA 0.1878 mg/L PBTK NA 95% Rat Human +DTXSID1048750 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048750 Fup 0.621 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048750 Vd NA 1.537 L/kg 1compartment NA NA Human Human +DTXSID1048750 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1048750 TK.Half.Life NA 16.01 hours 1compartment NA NA Human Human +DTXSID1048750 Css NA 0.5485 mg/L 3compartmentss NA 50% Human Human +DTXSID1048750 Css NA 4.24 mg/L 3compartmentss NA 95% Human Human +DTXSID1048750 Css NA 0.52 mg/L PBTK NA 50% Human Human +DTXSID1048750 Css NA 2.851 mg/L PBTK NA 95% Human Human +DTXSID1048750 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048750 Fup 0.621 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048750 Vd NA 1.55 L/kg 1compartment NA NA Rat Human DTXSID1048750 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048750 TK.Half.Life NA 0.6897 hours 1compartment NA NA Rat Human -DTXSID1048750 Css NA 0.02826 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048750 Css NA 0.2345 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048750 Css NA 0.02587 mg/L PBTK NA 50% Rat Human -DTXSID1048750 Css NA 0.1571 mg/L PBTK NA 95% Rat Human -DTXSID1048754 Clint NA 0.05624 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048754 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048754 Vd NA 0.6412 L/kg 1compartment NA NA Human Human -DTXSID1048754 TK.Half.Life NA NA hours 1compartment NA NA Human Human -DTXSID1048754 Css NA NA mg/L 3compartmentss NA 50% Human Human -DTXSID1048754 Css NA NA mg/L 3compartmentss NA 95% Human Human -DTXSID1048754 Css NA NA mg/L PBTK NA 50% Human Human -DTXSID1048754 Css NA NA mg/L PBTK NA 95% Human Human -DTXSID1048754 Clint NA 0.05624 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048754 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048754 Vd NA 0.7028 L/kg 1compartment NA NA Rat Human -DTXSID1048754 TK.Half.Life NA NA hours 1compartment NA NA Rat Human -DTXSID1048754 Css NA NA mg/L 3compartmentss NA 50% Rat Human -DTXSID1048754 Css NA NA mg/L 3compartmentss NA 95% Rat Human -DTXSID1048754 Css NA NA mg/L PBTK NA 50% Rat Human -DTXSID1048754 Css NA NA mg/L PBTK NA 95% Rat Human -DTXSID1048756 Clint NA 3.297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048756 Fup NA 0.2276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048756 Vd NA 1.388 L/kg 1compartment NA NA Human Human +DTXSID1048750 TK.Half.Life NA 5.506 hours 1compartment NA NA Rat Human +DTXSID1048750 Css NA 0.002874 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048750 Css NA 0.02435 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048750 Css NA 0.002654 mg/L PBTK NA 50% Rat Human +DTXSID1048750 Css NA 0.01574 mg/L PBTK NA 95% Rat Human +DTXSID1048756 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048756 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048756 Vd NA 0.7312 L/kg 1compartment NA NA Human Human DTXSID1048756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048756 TK.Half.Life NA 6.717 hours 1compartment NA NA Human Human -DTXSID1048756 Css NA 0.4732 mg/L 3compartmentss NA 50% Human Human -DTXSID1048756 Css NA 2.642 mg/L 3compartmentss NA 95% Human Human -DTXSID1048756 Css NA 0.3722 mg/L PBTK NA 50% Human Human -DTXSID1048756 Css NA 1.843 mg/L PBTK NA 95% Human Human -DTXSID1048756 Clint NA 3.297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048756 Fup NA 0.2276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048756 Vd NA 1.383 L/kg 1compartment NA NA Rat Human +DTXSID1048756 TK.Half.Life NA 2.049 hours 1compartment NA NA Human Human +DTXSID1048756 Css NA 0.2557 mg/L 3compartmentss NA 50% Human Human +DTXSID1048756 Css NA 1.557 mg/L 3compartmentss NA 95% Human Human +DTXSID1048756 Css NA 0.1805 mg/L PBTK NA 50% Human Human +DTXSID1048756 Css NA 1.009 mg/L PBTK NA 95% Human Human +DTXSID1048756 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048756 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048756 Vd NA 0.6576 L/kg 1compartment NA NA Rat Human DTXSID1048756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048756 TK.Half.Life NA 3.834 hours 1compartment NA NA Rat Human -DTXSID1048756 Css NA 0.2276 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048756 Css NA 0.9397 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048756 Css NA 0.1744 mg/L PBTK NA 50% Rat Human -DTXSID1048756 Css NA 0.603 mg/L PBTK NA 95% Rat Human -DTXSID1048758 Clint NA 6.522 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048758 Fup NA 0.1523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048758 Vd NA 1.434 L/kg 1compartment NA NA Human Human +DTXSID1048756 TK.Half.Life NA 1.045 hours 1compartment NA NA Rat Human +DTXSID1048756 Css NA 0.02991 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048756 Css NA 0.1347 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048756 Css NA 0.0212 mg/L PBTK NA 50% Rat Human +DTXSID1048756 Css NA 0.08526 mg/L PBTK NA 95% Rat Human +DTXSID1048758 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048758 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048758 Vd NA 1.592 L/kg 1compartment NA NA Human Human DTXSID1048758 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048758 TK.Half.Life NA 4.871 hours 1compartment NA NA Human Human -DTXSID1048758 Css NA 0.338 mg/L 3compartmentss NA 50% Human Human -DTXSID1048758 Css NA 2.555 mg/L 3compartmentss NA 95% Human Human -DTXSID1048758 Css NA 0.2759 mg/L PBTK NA 50% Human Human -DTXSID1048758 Css NA 1.801 mg/L PBTK NA 95% Human Human -DTXSID1048758 Clint NA 6.522 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048758 Fup NA 0.1523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048758 Vd NA 1.398 L/kg 1compartment NA NA Rat Human +DTXSID1048758 TK.Half.Life NA 4.335 hours 1compartment NA NA Human Human +DTXSID1048758 Css NA 0.2084 mg/L 3compartmentss NA 50% Human Human +DTXSID1048758 Css NA 1.409 mg/L 3compartmentss NA 95% Human Human +DTXSID1048758 Css NA 0.1848 mg/L PBTK NA 50% Human Human +DTXSID1048758 Css NA 1.089 mg/L PBTK NA 95% Human Human +DTXSID1048758 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048758 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048758 Vd NA 1.555 L/kg 1compartment NA NA Rat Human DTXSID1048758 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048758 TK.Half.Life NA 2.892 hours 1compartment NA NA Rat Human -DTXSID1048758 Css NA 0.1785 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048758 Css NA 1.064 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048758 Css NA 0.1403 mg/L PBTK NA 50% Rat Human -DTXSID1048758 Css NA 0.6851 mg/L PBTK NA 95% Rat Human -DTXSID1048831 Clint NA 40.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048831 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048831 Vd NA 1.525 L/kg 1compartment NA NA Human Human +DTXSID1048758 TK.Half.Life NA 2.527 hours 1compartment NA NA Rat Human +DTXSID1048758 Css NA 0.02454 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048758 Css NA 0.1277 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048758 Css NA 0.0221 mg/L PBTK NA 50% Rat Human +DTXSID1048758 Css NA 0.09303 mg/L PBTK NA 95% Rat Human +DTXSID1048831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048831 Fup 0.0684 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048831 Vd NA 0.3918 L/kg 1compartment NA NA Human Human DTXSID1048831 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048831 TK.Half.Life NA 5.471 hours 1compartment NA NA Human Human -DTXSID1048831 Css NA 0.479 mg/L 3compartmentss NA 50% Human Human -DTXSID1048831 Css NA 3.529 mg/L 3compartmentss NA 95% Human Human -DTXSID1048831 Css NA 0.3042 mg/L PBTK NA 50% Human Human -DTXSID1048831 Css NA 2.153 mg/L PBTK NA 95% Human Human -DTXSID1048831 Clint NA 40.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048831 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048831 Vd NA 1.138 L/kg 1compartment NA NA Rat Human +DTXSID1048831 TK.Half.Life NA 1.318 hours 1compartment NA NA Human Human +DTXSID1048831 Css NA 0.4255 mg/L 3compartmentss NA 50% Human Human +DTXSID1048831 Css NA 3.5 mg/L 3compartmentss NA 95% Human Human +DTXSID1048831 Css NA 0.2713 mg/L PBTK NA 50% Human Human +DTXSID1048831 Css NA 2.12 mg/L PBTK NA 95% Human Human +DTXSID1048831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048831 Fup 0.0684 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048831 Vd NA 0.3716 L/kg 1compartment NA NA Rat Human DTXSID1048831 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048831 TK.Half.Life NA 2.067 hours 1compartment NA NA Rat Human -DTXSID1048831 Css NA 0.2729 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048831 Css NA 1.686 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048831 Css NA 0.1618 mg/L PBTK NA 50% Rat Human -DTXSID1048831 Css NA 0.9641 mg/L PBTK NA 95% Rat Human -DTXSID1048833 Clint NA 5.054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048833 Fup NA 0.519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048833 Vd NA 2.804 L/kg 1compartment NA NA Human Human -DTXSID1048833 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1048833 TK.Half.Life NA 14.37 hours 1compartment NA NA Human Human -DTXSID1048833 Css NA 0.5194 mg/L 3compartmentss NA 50% Human Human -DTXSID1048833 Css NA 2.736 mg/L 3compartmentss NA 95% Human Human -DTXSID1048833 Css NA 0.4037 mg/L PBTK NA 50% Human Human -DTXSID1048833 Css NA 1.98 mg/L PBTK NA 95% Human Human -DTXSID1048833 Clint NA 5.054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048833 Fup NA 0.519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048833 Vd NA 2.163 L/kg 1compartment NA NA Rat Human +DTXSID1048831 TK.Half.Life NA 0.7685 hours 1compartment NA NA Rat Human +DTXSID1048831 Css NA 0.0564 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048831 Css NA 0.352 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048831 Css NA 0.03492 mg/L PBTK NA 50% Rat Human +DTXSID1048831 Css NA 0.2073 mg/L PBTK NA 95% Rat Human +DTXSID1048833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048833 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048833 Vd NA 2.003 L/kg 1compartment NA NA Human Human +DTXSID1048833 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1048833 TK.Half.Life NA 4.183 hours 1compartment NA NA Human Human +DTXSID1048833 Css NA 0.157 mg/L 3compartmentss NA 50% Human Human +DTXSID1048833 Css NA 1.058 mg/L 3compartmentss NA 95% Human Human +DTXSID1048833 Css NA 0.1139 mg/L PBTK NA 50% Human Human +DTXSID1048833 Css NA 0.7268 mg/L PBTK NA 95% Human Human +DTXSID1048833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048833 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048833 Vd NA 1.543 L/kg 1compartment NA NA Rat Human DTXSID1048833 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048833 TK.Half.Life NA 3.117 hours 1compartment NA NA Rat Human -DTXSID1048833 Css NA 0.2628 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048833 Css NA 1.006 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048833 Css NA 0.1975 mg/L PBTK NA 50% Rat Human -DTXSID1048833 Css NA 0.6955 mg/L PBTK NA 95% Rat Human -DTXSID1048835 Clint NA 12.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048835 Fup NA 0.1405 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048835 Vd NA 3.188 L/kg 1compartment NA NA Human Human -DTXSID1048835 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1048835 TK.Half.Life NA 37.41 hours 1compartment NA NA Human Human -DTXSID1048835 Css NA 1.337 mg/L 3compartmentss NA 50% Human Human -DTXSID1048835 Css NA 8.365 mg/L 3compartmentss NA 95% Human Human -DTXSID1048835 Css NA 0.9605 mg/L PBTK NA 50% Human Human -DTXSID1048835 Css NA 5.745 mg/L PBTK NA 95% Human Human -DTXSID1048835 Clint NA 12.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048835 Fup NA 0.1405 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048835 Vd NA 2.442 L/kg 1compartment NA NA Rat Human -DTXSID1048835 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1048835 TK.Half.Life NA 5.945 hours 1compartment NA NA Rat Human -DTXSID1048835 Css NA 0.7392 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048835 Css NA 3.534 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048835 Css NA 0.512 mg/L PBTK NA 50% Rat Human -DTXSID1048835 Css NA 2.37 mg/L PBTK NA 95% Rat Human -DTXSID1048837 Clint NA 17.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048837 Fup NA 0.4818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048837 Vd NA 2.401 L/kg 1compartment NA NA Human Human +DTXSID1048833 TK.Half.Life NA 1.424 hours 1compartment NA NA Rat Human +DTXSID1048833 Css NA 0.01999 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048833 Css NA 0.1005 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048833 Css NA 0.01437 mg/L PBTK NA 50% Rat Human +DTXSID1048833 Css NA 0.06973 mg/L PBTK NA 95% Rat Human +DTXSID1048835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048835 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048835 Vd NA 3.179 L/kg 1compartment NA NA Human Human +DTXSID1048835 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1048835 TK.Half.Life NA 26.81 hours 1compartment NA NA Human Human +DTXSID1048835 Css NA 0.8954 mg/L 3compartmentss NA 50% Human Human +DTXSID1048835 Css NA 5.842 mg/L 3compartmentss NA 95% Human Human +DTXSID1048835 Css NA 0.6403 mg/L PBTK NA 50% Human Human +DTXSID1048835 Css NA 3.935 mg/L PBTK NA 95% Human Human +DTXSID1048835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048835 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048835 Vd NA 2.422 L/kg 1compartment NA NA Rat Human +DTXSID1048835 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1048835 TK.Half.Life NA 4.266 hours 1compartment NA NA Rat Human +DTXSID1048835 Css NA 0.1181 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048835 Css NA 0.6732 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048835 Css NA 0.08352 mg/L PBTK NA 50% Rat Human +DTXSID1048835 Css NA 0.4665 mg/L PBTK NA 95% Rat Human +DTXSID1048837 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048837 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048837 Vd NA 2.167 L/kg 1compartment NA NA Human Human DTXSID1048837 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048837 TK.Half.Life NA 2.936 hours 1compartment NA NA Human Human -DTXSID1048837 Css NA 0.06648 mg/L 3compartmentss NA 50% Human Human -DTXSID1048837 Css NA 0.5227 mg/L 3compartmentss NA 95% Human Human -DTXSID1048837 Css NA 0.05852 mg/L PBTK NA 50% Human Human -DTXSID1048837 Css NA 0.4001 mg/L PBTK NA 95% Human Human -DTXSID1048837 Clint NA 17.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048837 Fup NA 0.4818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048837 Vd NA 2.04 L/kg 1compartment NA NA Rat Human +DTXSID1048837 TK.Half.Life NA 2.463 hours 1compartment NA NA Human Human +DTXSID1048837 Css NA 0.05346 mg/L 3compartmentss NA 50% Human Human +DTXSID1048837 Css NA 0.4227 mg/L 3compartmentss NA 95% Human Human +DTXSID1048837 Css NA 0.04572 mg/L PBTK NA 50% Human Human +DTXSID1048837 Css NA 0.3193 mg/L PBTK NA 95% Human Human +DTXSID1048837 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048837 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048837 Vd NA 1.857 L/kg 1compartment NA NA Rat Human DTXSID1048837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048837 TK.Half.Life NA 1.118 hours 1compartment NA NA Rat Human -DTXSID1048837 Css NA 0.03514 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048837 Css NA 0.207 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048837 Css NA 0.03004 mg/L PBTK NA 50% Rat Human -DTXSID1048837 Css NA 0.1519 mg/L PBTK NA 95% Rat Human -DTXSID1048839 Clint NA 66.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048839 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048839 Vd NA 2.682 L/kg 1compartment NA NA Human Human -DTXSID1048839 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1048839 TK.Half.Life NA 15.26 hours 1compartment NA NA Human Human -DTXSID1048839 Css NA 0.72 mg/L 3compartmentss NA 50% Human Human -DTXSID1048839 Css NA 5.098 mg/L 3compartmentss NA 95% Human Human -DTXSID1048839 Css NA 0.4818 mg/L PBTK NA 50% Human Human -DTXSID1048839 Css NA 3.244 mg/L PBTK NA 95% Human Human -DTXSID1048839 Clint NA 66.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048839 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048839 Vd NA 2.002 L/kg 1compartment NA NA Rat Human -DTXSID1048839 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048839 TK.Half.Life NA 3.48 hours 1compartment NA NA Rat Human -DTXSID1048839 Css NA 0.4017 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048839 Css NA 2.303 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048839 Css NA 0.2552 mg/L PBTK NA 50% Rat Human -DTXSID1048839 Css NA 1.427 mg/L PBTK NA 95% Rat Human -DTXSID1048881 Clint NA 75.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048881 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048881 Vd NA 3.914 L/kg 1compartment NA NA Human Human +DTXSID1048837 TK.Half.Life NA 0.984 hours 1compartment NA NA Rat Human +DTXSID1048837 Css NA 0.006592 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048837 Css NA 0.03964 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048837 Css NA 0.005736 mg/L PBTK NA 50% Rat Human +DTXSID1048837 Css NA 0.02903 mg/L PBTK NA 95% Rat Human +DTXSID1048839 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048839 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048839 Vd NA 2.608 L/kg 1compartment NA NA Human Human +DTXSID1048839 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID1048839 TK.Half.Life NA 146.6 hours 1compartment NA NA Human Human +DTXSID1048839 Css NA 7.972 mg/L 3compartmentss NA 50% Human Human +DTXSID1048839 Css NA 54.6 mg/L 3compartmentss NA 95% Human Human +DTXSID1048839 Css NA 5.312 mg/L PBTK NA 50% Human Human +DTXSID1048839 Css NA 34.68 mg/L PBTK NA 95% Human Human +DTXSID1048839 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048839 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048839 Vd NA 1.944 L/kg 1compartment NA NA Rat Human +DTXSID1048839 Days.Css NA 15 Days PBTK NA NA Rat Human +DTXSID1048839 TK.Half.Life NA 32.24 hours 1compartment NA NA Rat Human +DTXSID1048839 Css NA 1.02 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048839 Css NA 5.493 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048839 Css NA 0.6663 mg/L PBTK NA 50% Rat Human +DTXSID1048839 Css NA 3.451 mg/L PBTK NA 95% Rat Human +DTXSID1048881 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048881 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048881 Vd NA 2.757 L/kg 1compartment NA NA Human Human DTXSID1048881 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048881 TK.Half.Life NA 2.068 hours 1compartment NA NA Human Human -DTXSID1048881 Css NA 0.008536 mg/L 3compartmentss NA 50% Human Human -DTXSID1048881 Css NA 0.08216 mg/L 3compartmentss NA 95% Human Human -DTXSID1048881 Css NA 0.01093 mg/L PBTK NA 50% Human Human -DTXSID1048881 Css NA 0.07928 mg/L PBTK NA 95% Human Human -DTXSID1048881 Clint NA 75.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048881 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048881 Vd NA 3.983 L/kg 1compartment NA NA Rat Human +DTXSID1048881 TK.Half.Life NA 2.912 hours 1compartment NA NA Human Human +DTXSID1048881 Css NA 0.04554 mg/L 3compartmentss NA 50% Human Human +DTXSID1048881 Css NA 0.4022 mg/L 3compartmentss NA 95% Human Human +DTXSID1048881 Css NA 0.04673 mg/L PBTK NA 50% Human Human +DTXSID1048881 Css NA 0.3387 mg/L PBTK NA 95% Human Human +DTXSID1048881 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048881 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048881 Vd NA 2.788 L/kg 1compartment NA NA Rat Human DTXSID1048881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048881 TK.Half.Life NA 1.025 hours 1compartment NA NA Rat Human -DTXSID1048881 Css NA 0.004523 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048881 Css NA 0.03597 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048881 Css NA 0.00576 mg/L PBTK NA 50% Rat Human -DTXSID1048881 Css NA 0.03433 mg/L PBTK NA 95% Rat Human -DTXSID1048883 Clint NA 76.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048883 Fup NA 0.4596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048883 Vd NA 4.508 L/kg 1compartment NA NA Human Human +DTXSID1048881 TK.Half.Life NA 1.635 hours 1compartment NA NA Rat Human +DTXSID1048881 Css NA 0.00559 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048881 Css NA 0.0388 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048881 Css NA 0.005947 mg/L PBTK NA 50% Rat Human +DTXSID1048881 Css NA 0.03169 mg/L PBTK NA 95% Rat Human +DTXSID1048883 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048883 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048883 Vd NA 2.757 L/kg 1compartment NA NA Human Human DTXSID1048883 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048883 TK.Half.Life NA 2.078 hours 1compartment NA NA Human Human -DTXSID1048883 Css NA 0.006592 mg/L 3compartmentss NA 50% Human Human -DTXSID1048883 Css NA 0.06732 mg/L 3compartmentss NA 95% Human Human -DTXSID1048883 Css NA 0.009205 mg/L PBTK NA 50% Human Human -DTXSID1048883 Css NA 0.06815 mg/L PBTK NA 95% Human Human -DTXSID1048883 Clint NA 76.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048883 Fup NA 0.4596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048883 Vd NA 4.597 L/kg 1compartment NA NA Rat Human +DTXSID1048883 TK.Half.Life NA 2.912 hours 1compartment NA NA Human Human +DTXSID1048883 Css NA 0.04554 mg/L 3compartmentss NA 50% Human Human +DTXSID1048883 Css NA 0.4022 mg/L 3compartmentss NA 95% Human Human +DTXSID1048883 Css NA 0.04673 mg/L PBTK NA 50% Human Human +DTXSID1048883 Css NA 0.3387 mg/L PBTK NA 95% Human Human +DTXSID1048883 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048883 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048883 Vd NA 2.788 L/kg 1compartment NA NA Rat Human DTXSID1048883 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048883 TK.Half.Life NA 1.022 hours 1compartment NA NA Rat Human -DTXSID1048883 Css NA 0.003345 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048883 Css NA 0.03233 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048883 Css NA 0.004789 mg/L PBTK NA 50% Rat Human -DTXSID1048883 Css NA 0.03062 mg/L PBTK NA 95% Rat Human -DTXSID1048885 Clint NA 219.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048885 Fup NA 0.5175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048885 Vd NA 4.179 L/kg 1compartment NA NA Human Human +DTXSID1048883 TK.Half.Life NA 1.635 hours 1compartment NA NA Rat Human +DTXSID1048883 Css NA 0.00559 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048883 Css NA 0.0388 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048883 Css NA 0.005947 mg/L PBTK NA 50% Rat Human +DTXSID1048883 Css NA 0.03169 mg/L PBTK NA 95% Rat Human +DTXSID1048885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048885 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048885 Vd NA 3.446 L/kg 1compartment NA NA Human Human DTXSID1048885 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048885 TK.Half.Life NA 1.686 hours 1compartment NA NA Human Human -DTXSID1048885 Css NA 0.002276 mg/L 3compartmentss NA 50% Human Human -DTXSID1048885 Css NA 0.02434 mg/L 3compartmentss NA 95% Human Human -DTXSID1048885 Css NA 0.003074 mg/L PBTK NA 50% Human Human -DTXSID1048885 Css NA 0.02369 mg/L PBTK NA 95% Human Human -DTXSID1048885 Clint NA 219.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048885 Fup NA 0.5175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048885 Vd NA 4.266 L/kg 1compartment NA NA Rat Human +DTXSID1048885 TK.Half.Life NA 2.638 hours 1compartment NA NA Human Human +DTXSID1048885 Css NA 0.02478 mg/L 3compartmentss NA 50% Human Human +DTXSID1048885 Css NA 0.2612 mg/L 3compartmentss NA 95% Human Human +DTXSID1048885 Css NA 0.03008 mg/L PBTK NA 50% Human Human +DTXSID1048885 Css NA 0.2382 mg/L PBTK NA 95% Human Human +DTXSID1048885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048885 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048885 Vd NA 3.504 L/kg 1compartment NA NA Rat Human DTXSID1048885 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048885 TK.Half.Life NA 0.78 hours 1compartment NA NA Rat Human -DTXSID1048885 Css NA 0.001163 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048885 Css NA 0.01249 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048885 Css NA 0.001607 mg/L PBTK NA 50% Rat Human -DTXSID1048885 Css NA 0.01114 mg/L PBTK NA 95% Rat Human -DTXSID1048887 Clint NA 167.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048887 Fup NA 0.6285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048887 Vd NA 3.471 L/kg 1compartment NA NA Human Human -DTXSID1048887 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048887 TK.Half.Life NA 1.465 hours 1compartment NA NA Human Human -DTXSID1048887 Css NA 0.002909 mg/L 3compartmentss NA 50% Human Human -DTXSID1048887 Css NA 0.03987 mg/L 3compartmentss NA 95% Human Human -DTXSID1048887 Css NA 0.00364 mg/L PBTK NA 50% Human Human -DTXSID1048887 Css NA 0.03501 mg/L PBTK NA 95% Human Human -DTXSID1048887 Clint NA 167.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048887 Fup NA 0.6285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048887 Vd NA 3.511 L/kg 1compartment NA NA Rat Human -DTXSID1048887 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048887 TK.Half.Life NA 0.6723 hours 1compartment NA NA Rat Human -DTXSID1048887 Css NA 0.00146 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048887 Css NA 0.01952 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048887 Css NA 0.001872 mg/L PBTK NA 50% Rat Human -DTXSID1048887 Css NA 0.01581 mg/L PBTK NA 95% Rat Human -DTXSID1048889 Clint NA 196.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048889 Fup NA 0.4233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048889 Vd NA 4.713 L/kg 1compartment NA NA Human Human +DTXSID1048885 TK.Half.Life NA 1.443 hours 1compartment NA NA Rat Human +DTXSID1048885 Css NA 0.002986 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048885 Css NA 0.02529 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048885 Css NA 0.003802 mg/L PBTK NA 50% Rat Human +DTXSID1048885 Css NA 0.02285 mg/L PBTK NA 95% Rat Human +DTXSID1048887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048887 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048887 Vd NA 3.118 L/kg 1compartment NA NA Human Human +DTXSID1048887 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID1048887 TK.Half.Life NA 42.29 hours 1compartment NA NA Human Human +DTXSID1048887 Css NA 0.9238 mg/L 3compartmentss NA 50% Human Human +DTXSID1048887 Css NA 5.721 mg/L 3compartmentss NA 95% Human Human +DTXSID1048887 Css NA 1.118 mg/L PBTK NA 50% Human Human +DTXSID1048887 Css NA 4.514 mg/L PBTK NA 95% Human Human +DTXSID1048887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048887 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048887 Vd NA 3.146 L/kg 1compartment NA NA Rat Human +DTXSID1048887 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1048887 TK.Half.Life NA 14.52 hours 1compartment NA NA Rat Human +DTXSID1048887 Css NA 0.05615 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048887 Css NA 0.3196 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048887 Css NA 0.06978 mg/L PBTK NA 50% Rat Human +DTXSID1048887 Css NA 0.2423 mg/L PBTK NA 95% Rat Human +DTXSID1048889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048889 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048889 Vd NA 3.838 L/kg 1compartment NA NA Human Human DTXSID1048889 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048889 TK.Half.Life NA 1.907 hours 1compartment NA NA Human Human -DTXSID1048889 Css NA 0.002682 mg/L 3compartmentss NA 50% Human Human -DTXSID1048889 Css NA 0.02779 mg/L 3compartmentss NA 95% Human Human -DTXSID1048889 Css NA 0.003798 mg/L PBTK NA 50% Human Human -DTXSID1048889 Css NA 0.02907 mg/L PBTK NA 95% Human Human -DTXSID1048889 Clint NA 196.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048889 Fup NA 0.4233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048889 Vd NA 4.795 L/kg 1compartment NA NA Rat Human +DTXSID1048889 TK.Half.Life NA 3.416 hours 1compartment NA NA Human Human +DTXSID1048889 Css NA 0.03294 mg/L 3compartmentss NA 50% Human Human +DTXSID1048889 Css NA 0.3096 mg/L 3compartmentss NA 95% Human Human +DTXSID1048889 Css NA 0.04041 mg/L PBTK NA 50% Human Human +DTXSID1048889 Css NA 0.2943 mg/L PBTK NA 95% Human Human +DTXSID1048889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048889 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048889 Vd NA 3.887 L/kg 1compartment NA NA Rat Human DTXSID1048889 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048889 TK.Half.Life NA 0.8858 hours 1compartment NA NA Rat Human -DTXSID1048889 Css NA 0.001387 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048889 Css NA 0.01279 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048889 Css NA 0.002007 mg/L PBTK NA 50% Rat Human -DTXSID1048889 Css NA 0.01306 mg/L PBTK NA 95% Rat Human -DTXSID1048910 Clint NA 4.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048910 Fup NA 0.354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048910 Vd NA 5.166 L/kg 1compartment NA NA Human Human +DTXSID1048889 TK.Half.Life NA 1.892 hours 1compartment NA NA Rat Human +DTXSID1048889 Css NA 0.003949 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048889 Css NA 0.02794 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048889 Css NA 0.005018 mg/L PBTK NA 50% Rat Human +DTXSID1048889 Css NA 0.02682 mg/L PBTK NA 95% Rat Human +DTXSID1048910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048910 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048910 Vd NA 2.354 L/kg 1compartment NA NA Human Human DTXSID1048910 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048910 TK.Half.Life NA 10.33 hours 1compartment NA NA Human Human -DTXSID1048910 Css NA 0.0979 mg/L 3compartmentss NA 50% Human Human -DTXSID1048910 Css NA 0.8046 mg/L 3compartmentss NA 95% Human Human -DTXSID1048910 Css NA 0.1546 mg/L PBTK NA 50% Human Human -DTXSID1048910 Css NA 0.8449 mg/L PBTK NA 95% Human Human -DTXSID1048910 Clint NA 4.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048910 Fup NA 0.354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048910 Vd NA 5.245 L/kg 1compartment NA NA Rat Human +DTXSID1048910 TK.Half.Life NA 2.046 hours 1compartment NA NA Human Human +DTXSID1048910 Css NA 0.03155 mg/L 3compartmentss NA 50% Human Human +DTXSID1048910 Css NA 0.297 mg/L 3compartmentss NA 95% Human Human +DTXSID1048910 Css NA 0.03258 mg/L PBTK NA 50% Human Human +DTXSID1048910 Css NA 0.2455 mg/L PBTK NA 95% Human Human +DTXSID1048910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048910 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048910 Vd NA 2.366 L/kg 1compartment NA NA Rat Human DTXSID1048910 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048910 TK.Half.Life NA 6.075 hours 1compartment NA NA Rat Human -DTXSID1048910 Css NA 0.04646 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048910 Css NA 0.2994 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048910 Css NA 0.07476 mg/L PBTK NA 50% Rat Human -DTXSID1048910 Css NA 0.299 mg/L PBTK NA 95% Rat Human -DTXSID1048912 Clint NA 3.448 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048912 Fup NA 0.1593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048912 Vd NA 3.537 L/kg 1compartment NA NA Human Human -DTXSID1048912 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1048912 TK.Half.Life NA 26.49 hours 1compartment NA NA Human Human -DTXSID1048912 Css NA 0.7131 mg/L 3compartmentss NA 50% Human Human -DTXSID1048912 Css NA 4.053 mg/L 3compartmentss NA 95% Human Human -DTXSID1048912 Css NA 0.6502 mg/L PBTK NA 50% Human Human -DTXSID1048912 Css NA 3.303 mg/L PBTK NA 95% Human Human -DTXSID1048912 Clint NA 3.448 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048912 Fup NA 0.1593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048912 Vd NA 3.174 L/kg 1compartment NA NA Rat Human -DTXSID1048912 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1048912 TK.Half.Life NA 9.499 hours 1compartment NA NA Rat Human -DTXSID1048912 Css NA 0.3548 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048912 Css NA 1.565 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048912 Css NA 0.32 mg/L PBTK NA 50% Rat Human -DTXSID1048912 Css NA 1.165 mg/L PBTK NA 95% Rat Human -DTXSID1048914 Clint NA 11.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048914 Fup NA 0.5469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048914 Vd NA 2.291 L/kg 1compartment NA NA Human Human +DTXSID1048910 TK.Half.Life NA 1.094 hours 1compartment NA NA Rat Human +DTXSID1048910 Css NA 0.003805 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048910 Css NA 0.02861 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048910 Css NA 0.00403 mg/L PBTK NA 50% Rat Human +DTXSID1048910 Css NA 0.02313 mg/L PBTK NA 95% Rat Human +DTXSID1048912 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048912 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048912 Vd NA 3.122 L/kg 1compartment NA NA Human Human +DTXSID1048912 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1048912 TK.Half.Life NA 7.274 hours 1compartment NA NA Human Human +DTXSID1048912 Css NA 0.2004 mg/L 3compartmentss NA 50% Human Human +DTXSID1048912 Css NA 1.561 mg/L 3compartmentss NA 95% Human Human +DTXSID1048912 Css NA 0.1627 mg/L PBTK NA 50% Human Human +DTXSID1048912 Css NA 1.14 mg/L PBTK NA 95% Human Human +DTXSID1048912 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048912 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048912 Vd NA 2.716 L/kg 1compartment NA NA Rat Human +DTXSID1048912 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1048912 TK.Half.Life NA 2.724 hours 1compartment NA NA Rat Human +DTXSID1048912 Css NA 0.02545 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048912 Css NA 0.1616 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048912 Css NA 0.02087 mg/L PBTK NA 50% Rat Human +DTXSID1048912 Css NA 0.1211 mg/L PBTK NA 95% Rat Human +DTXSID1048914 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048914 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048914 Vd NA 2.308 L/kg 1compartment NA NA Human Human DTXSID1048914 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048914 TK.Half.Life NA 2.399 hours 1compartment NA NA Human Human -DTXSID1048914 Css NA 0.05574 mg/L 3compartmentss NA 50% Human Human -DTXSID1048914 Css NA 0.5678 mg/L 3compartmentss NA 95% Human Human -DTXSID1048914 Css NA 0.05639 mg/L PBTK NA 50% Human Human -DTXSID1048914 Css NA 0.4388 mg/L PBTK NA 95% Human Human -DTXSID1048914 Clint NA 11.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048914 Fup NA 0.5469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048914 Vd NA 2.319 L/kg 1compartment NA NA Rat Human +DTXSID1048914 TK.Half.Life NA 3.181 hours 1compartment NA NA Human Human +DTXSID1048914 Css NA 0.0878 mg/L 3compartmentss NA 50% Human Human +DTXSID1048914 Css NA 0.9195 mg/L 3compartmentss NA 95% Human Human +DTXSID1048914 Css NA 0.08941 mg/L PBTK NA 50% Human Human +DTXSID1048914 Css NA 0.6934 mg/L PBTK NA 95% Human Human +DTXSID1048914 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048914 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048914 Vd NA 2.337 L/kg 1compartment NA NA Rat Human DTXSID1048914 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048914 TK.Half.Life NA 1.324 hours 1compartment NA NA Rat Human -DTXSID1048914 Css NA 0.0279 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048914 Css NA 0.2524 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048914 Css NA 0.02802 mg/L PBTK NA 50% Rat Human -DTXSID1048914 Css NA 0.1733 mg/L PBTK NA 95% Rat Human -DTXSID1048916 Clint NA 15.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048916 Fup NA 0.1028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048916 Vd NA 3.44 L/kg 1compartment NA NA Human Human +DTXSID1048914 TK.Half.Life NA 1.796 hours 1compartment NA NA Rat Human +DTXSID1048914 Css NA 0.009708 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048914 Css NA 0.09035 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048914 Css NA 0.01032 mg/L PBTK NA 50% Rat Human +DTXSID1048914 Css NA 0.06217 mg/L PBTK NA 95% Rat Human +DTXSID1048916 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048916 Fup 0.0853 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048916 Vd NA 2.965 L/kg 1compartment NA NA Human Human DTXSID1048916 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048916 TK.Half.Life NA 8.425 hours 1compartment NA NA Human Human -DTXSID1048916 Css NA 0.2132 mg/L 3compartmentss NA 50% Human Human -DTXSID1048916 Css NA 1.583 mg/L 3compartmentss NA 95% Human Human -DTXSID1048916 Css NA 0.1852 mg/L PBTK NA 50% Human Human -DTXSID1048916 Css NA 1.258 mg/L PBTK NA 95% Human Human -DTXSID1048916 Clint NA 15.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048916 Fup NA 0.1028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048916 Vd NA 3.042 L/kg 1compartment NA NA Rat Human +DTXSID1048916 TK.Half.Life NA 6.139 hours 1compartment NA NA Human Human +DTXSID1048916 Css NA 0.1718 mg/L 3compartmentss NA 50% Human Human +DTXSID1048916 Css NA 1.477 mg/L 3compartmentss NA 95% Human Human +DTXSID1048916 Css NA 0.1434 mg/L PBTK NA 50% Human Human +DTXSID1048916 Css NA 1.067 mg/L PBTK NA 95% Human Human +DTXSID1048916 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048916 Fup 0.0853 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048916 Vd NA 2.69 L/kg 1compartment NA NA Rat Human DTXSID1048916 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048916 TK.Half.Life NA 3.122 hours 1compartment NA NA Rat Human -DTXSID1048916 Css NA 0.1151 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048916 Css NA 0.7036 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048916 Css NA 0.09714 mg/L PBTK NA 50% Rat Human -DTXSID1048916 Css NA 0.5219 mg/L PBTK NA 95% Rat Human -DTXSID1048918 Clint NA 294 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048918 Fup NA 0.0288 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048918 Vd NA 1.934 L/kg 1compartment NA NA Human Human +DTXSID1048916 TK.Half.Life NA 2.731 hours 1compartment NA NA Rat Human +DTXSID1048916 Css NA 0.02221 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048916 Css NA 0.1508 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048916 Css NA 0.01859 mg/L PBTK NA 50% Rat Human +DTXSID1048916 Css NA 0.1106 mg/L PBTK NA 95% Rat Human +DTXSID1048918 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048918 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048918 Vd NA 0.6583 L/kg 1compartment NA NA Human Human DTXSID1048918 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048918 TK.Half.Life NA 2.694 hours 1compartment NA NA Human Human -DTXSID1048918 Css NA 0.0868 mg/L 3compartmentss NA 50% Human Human -DTXSID1048918 Css NA 0.7579 mg/L 3compartmentss NA 95% Human Human -DTXSID1048918 Css NA 0.05582 mg/L PBTK NA 50% Human Human -DTXSID1048918 Css NA 0.4677 mg/L PBTK NA 95% Human Human -DTXSID1048918 Clint NA 294 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048918 Fup NA 0.0288 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048918 Vd NA 1.442 L/kg 1compartment NA NA Rat Human +DTXSID1048918 TK.Half.Life NA 1.434 hours 1compartment NA NA Human Human +DTXSID1048918 Css NA 0.2083 mg/L 3compartmentss NA 50% Human Human +DTXSID1048918 Css NA 1.665 mg/L 3compartmentss NA 95% Human Human +DTXSID1048918 Css NA 0.1347 mg/L PBTK NA 50% Human Human +DTXSID1048918 Css NA 1.018 mg/L PBTK NA 95% Human Human +DTXSID1048918 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048918 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048918 Vd NA 0.5614 L/kg 1compartment NA NA Rat Human DTXSID1048918 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048918 TK.Half.Life NA 0.8916 hours 1compartment NA NA Rat Human -DTXSID1048918 Css NA 0.04992 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048918 Css NA 0.351 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048918 Css NA 0.03032 mg/L PBTK NA 50% Rat Human -DTXSID1048918 Css NA 0.2079 mg/L PBTK NA 95% Rat Human +DTXSID1048918 TK.Half.Life NA 0.6968 hours 1compartment NA NA Rat Human +DTXSID1048918 Css NA 0.027 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048918 Css NA 0.1715 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048918 Css NA 0.01702 mg/L PBTK NA 50% Rat Human +DTXSID1048918 Css NA 0.1022 mg/L PBTK NA 95% Rat Human DTXSID1048960 Clint NA 4.088 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1048960 Fup NA 0.1249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048960 Vd NA 0.3218 L/kg 1compartment NA NA Human Human +DTXSID1048960 Vd NA 0.3786 L/kg 1compartment NA NA Human Human DTXSID1048960 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048960 TK.Half.Life NA 2.344 hours 1compartment NA NA Human Human -DTXSID1048960 Css NA 1.074 mg/L 3compartmentss NA 50% Human Human -DTXSID1048960 Css NA 6.878 mg/L 3compartmentss NA 95% Human Human -DTXSID1048960 Css NA 0.6772 mg/L PBTK NA 50% Human Human -DTXSID1048960 Css NA 4.125 mg/L PBTK NA 95% Human Human +DTXSID1048960 TK.Half.Life NA 2.77 hours 1compartment NA NA Human Human +DTXSID1048960 Css NA 0.5494 mg/L 3compartmentss NA 50% Human Human +DTXSID1048960 Css NA 3.853 mg/L 3compartmentss NA 95% Human Human +DTXSID1048960 Css NA 0.357 mg/L PBTK NA 50% Human Human +DTXSID1048960 Css NA 2.352 mg/L PBTK NA 95% Human Human DTXSID1048960 Clint NA 4.088 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1048960 Fup NA 0.1249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048960 Vd NA 0.3211 L/kg 1compartment NA NA Rat Human +DTXSID1048960 Vd NA 0.3741 L/kg 1compartment NA NA Rat Human DTXSID1048960 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048960 TK.Half.Life NA 1.386 hours 1compartment NA NA Rat Human -DTXSID1048960 Css NA 0.5432 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048960 Css NA 2.566 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048960 Css NA 0.3217 mg/L PBTK NA 50% Rat Human -DTXSID1048960 Css NA 1.435 mg/L PBTK NA 95% Rat Human +DTXSID1048960 TK.Half.Life NA 1.623 hours 1compartment NA NA Rat Human +DTXSID1048960 Css NA 0.005378 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048960 Css NA 0.03255 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048960 Css NA 0.003279 mg/L PBTK NA 50% Rat Human +DTXSID1048960 Css NA 0.01869 mg/L PBTK NA 95% Rat Human DTXSID1048962 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1048962 Fup NA 0.746 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048962 Vd NA 0.6588 L/kg 1compartment NA NA Human Human +DTXSID1048962 Vd NA 0.6821 L/kg 1compartment NA NA Human Human DTXSID1048962 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048962 TK.Half.Life NA 5.714 hours 1compartment NA NA Human Human -DTXSID1048962 Css NA 1.07 mg/L 3compartmentss NA 50% Human Human -DTXSID1048962 Css NA 6.569 mg/L 3compartmentss NA 95% Human Human -DTXSID1048962 Css NA 0.8513 mg/L PBTK NA 50% Human Human -DTXSID1048962 Css NA 4.159 mg/L PBTK NA 95% Human Human +DTXSID1048962 TK.Half.Life NA 5.914 hours 1compartment NA NA Human Human +DTXSID1048962 Css NA 0.9108 mg/L 3compartmentss NA 50% Human Human +DTXSID1048962 Css NA 5.485 mg/L 3compartmentss NA 95% Human Human +DTXSID1048962 Css NA 0.7262 mg/L PBTK NA 50% Human Human +DTXSID1048962 Css NA 3.451 mg/L PBTK NA 95% Human Human DTXSID1048962 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1048962 Fup NA 0.746 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048962 Vd NA 0.698 L/kg 1compartment NA NA Rat Human +DTXSID1048962 Vd NA 0.7175 L/kg 1compartment NA NA Rat Human DTXSID1048962 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048962 TK.Half.Life NA 2.063 hours 1compartment NA NA Rat Human -DTXSID1048962 Css NA 0.275 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048962 Css NA 1.697 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048962 Css NA 0.2111 mg/L PBTK NA 50% Rat Human -DTXSID1048962 Css NA 0.9981 mg/L PBTK NA 95% Rat Human -DTXSID1048964 Clint NA 1.005 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048964 Fup NA 0.1773 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048964 Vd NA 0.6032 L/kg 1compartment NA NA Human Human -DTXSID1048964 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048964 TK.Half.Life NA 8.582 hours 1compartment NA NA Human Human -DTXSID1048964 Css NA 1.728 mg/L 3compartmentss NA 50% Human Human -DTXSID1048964 Css NA 7.397 mg/L 3compartmentss NA 95% Human Human -DTXSID1048964 Css NA 1.16 mg/L PBTK NA 50% Human Human -DTXSID1048964 Css NA 4.499 mg/L PBTK NA 95% Human Human -DTXSID1048964 Clint NA 1.005 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048964 Fup NA 0.1773 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048964 Vd NA 0.5169 L/kg 1compartment NA NA Rat Human +DTXSID1048962 TK.Half.Life NA 2.121 hours 1compartment NA NA Rat Human +DTXSID1048962 Css NA 0.01714 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048962 Css NA 0.1376 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048962 Css NA 0.01324 mg/L PBTK NA 50% Rat Human +DTXSID1048962 Css NA 0.08665 mg/L PBTK NA 95% Rat Human +DTXSID1048964 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048964 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048964 Vd NA 0.7104 L/kg 1compartment NA NA Human Human +DTXSID1048964 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1048964 TK.Half.Life NA 17.27 hours 1compartment NA NA Human Human +DTXSID1048964 Css NA 2.409 mg/L 3compartmentss NA 50% Human Human +DTXSID1048964 Css NA 9.495 mg/L 3compartmentss NA 95% Human Human +DTXSID1048964 Css NA 1.703 mg/L PBTK NA 50% Human Human +DTXSID1048964 Css NA 6.036 mg/L PBTK NA 95% Human Human +DTXSID1048964 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048964 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048964 Vd NA 0.6177 L/kg 1compartment NA NA Rat Human DTXSID1048964 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048964 TK.Half.Life NA 3.573 hours 1compartment NA NA Rat Human -DTXSID1048964 Css NA 0.7083 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048964 Css NA 2.355 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048964 Css NA 0.4476 mg/L PBTK NA 50% Rat Human -DTXSID1048964 Css NA 1.351 mg/L PBTK NA 95% Rat Human -DTXSID1048966 Clint NA 18.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048966 Fup NA 0.512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048966 Vd NA 0.4452 L/kg 1compartment NA NA Human Human -DTXSID1048966 TK.Half.Life NA NA hours 1compartment NA NA Human Human -DTXSID1048966 Css NA NA mg/L 3compartmentss NA 50% Human Human -DTXSID1048966 Css NA NA mg/L 3compartmentss NA 95% Human Human -DTXSID1048966 Css NA NA mg/L PBTK NA 50% Human Human -DTXSID1048966 Css NA NA mg/L PBTK NA 95% Human Human -DTXSID1048966 Clint NA 18.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048966 Fup NA 0.512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048966 Vd NA 0.4846 L/kg 1compartment NA NA Rat Human -DTXSID1048966 TK.Half.Life NA NA hours 1compartment NA NA Rat Human -DTXSID1048966 Css NA NA mg/L 3compartmentss NA 50% Rat Human -DTXSID1048966 Css NA NA mg/L 3compartmentss NA 95% Rat Human -DTXSID1048966 Css NA NA mg/L PBTK NA 50% Rat Human -DTXSID1048966 Css NA NA mg/L PBTK NA 95% Rat Human -DTXSID1048968 Clint NA 28.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048968 Fup NA 0.0675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1048968 Vd NA 3.705 L/kg 1compartment NA NA Human Human +DTXSID1048964 TK.Half.Life NA 4.951 hours 1compartment NA NA Rat Human +DTXSID1048964 Css NA 0.05734 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048964 Css NA 0.315 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048964 Css NA 0.0401 mg/L PBTK NA 50% Rat Human +DTXSID1048964 Css NA 0.1965 mg/L PBTK NA 95% Rat Human +DTXSID1048968 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048968 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1048968 Vd NA 3.226 L/kg 1compartment NA NA Human Human DTXSID1048968 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1048968 TK.Half.Life NA 3.697 hours 1compartment NA NA Human Human -DTXSID1048968 Css NA 0.04766 mg/L 3compartmentss NA 50% Human Human -DTXSID1048968 Css NA 0.3737 mg/L 3compartmentss NA 95% Human Human -DTXSID1048968 Css NA 0.04286 mg/L PBTK NA 50% Human Human -DTXSID1048968 Css NA 0.3012 mg/L PBTK NA 95% Human Human -DTXSID1048968 Clint NA 28.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048968 Fup NA 0.0675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1048968 Vd NA 3.306 L/kg 1compartment NA NA Rat Human +DTXSID1048968 TK.Half.Life NA 4.104 hours 1compartment NA NA Human Human +DTXSID1048968 Css NA 0.07252 mg/L 3compartmentss NA 50% Human Human +DTXSID1048968 Css NA 0.5663 mg/L 3compartmentss NA 95% Human Human +DTXSID1048968 Css NA 0.0574 mg/L PBTK NA 50% Human Human +DTXSID1048968 Css NA 0.415 mg/L PBTK NA 95% Human Human +DTXSID1048968 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048968 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1048968 Vd NA 2.732 L/kg 1compartment NA NA Rat Human DTXSID1048968 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1048968 TK.Half.Life NA 1.401 hours 1compartment NA NA Rat Human -DTXSID1048968 Css NA 0.02584 mg/L 3compartmentss NA 50% Rat Human -DTXSID1048968 Css NA 0.1691 mg/L 3compartmentss NA 95% Rat Human -DTXSID1048968 Css NA 0.0229 mg/L PBTK NA 50% Rat Human -DTXSID1048968 Css NA 0.1282 mg/L PBTK NA 95% Rat Human -DTXSID1049015 Clint NA 16.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049015 Fup NA 0.0436 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049015 Vd NA 3.061 L/kg 1compartment NA NA Human Human -DTXSID1049015 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID1049015 TK.Half.Life NA 72.94 hours 1compartment NA NA Human Human -DTXSID1049015 Css NA 2.923 mg/L 3compartmentss NA 50% Human Human -DTXSID1049015 Css NA 18.96 mg/L 3compartmentss NA 95% Human Human -DTXSID1049015 Css NA 2.031 mg/L PBTK NA 50% Human Human -DTXSID1049015 Css NA 12.58 mg/L PBTK NA 95% Human Human -DTXSID1049015 Clint NA 16.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049015 Fup NA 0.0436 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049015 Vd NA 2.295 L/kg 1compartment NA NA Rat Human -DTXSID1049015 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID1049015 TK.Half.Life NA 10.7 hours 1compartment NA NA Rat Human -DTXSID1049015 Css NA 1.65 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049015 Css NA 8.527 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049015 Css NA 1.093 mg/L PBTK NA 50% Rat Human -DTXSID1049015 Css NA 5.504 mg/L PBTK NA 95% Rat Human -DTXSID1049017 Clint NA 82.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049017 Fup NA 0.8178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049017 Vd NA 4.064 L/kg 1compartment NA NA Human Human +DTXSID1048968 TK.Half.Life NA 1.418 hours 1compartment NA NA Rat Human +DTXSID1048968 Css NA 0.009563 mg/L 3compartmentss NA 50% Rat Human +DTXSID1048968 Css NA 0.06293 mg/L 3compartmentss NA 95% Rat Human +DTXSID1048968 Css NA 0.007602 mg/L PBTK NA 50% Rat Human +DTXSID1048968 Css NA 0.04617 mg/L PBTK NA 95% Rat Human +DTXSID1049011 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049011 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049011 Vd NA 4.834 L/kg 1compartment NA NA Human Human +DTXSID1049011 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1049011 TK.Half.Life NA 4.023 hours 1compartment NA NA Human Human +DTXSID1049011 Css NA 0.02786 mg/L 3compartmentss NA 50% Human Human +DTXSID1049011 Css NA 0.2484 mg/L 3compartmentss NA 95% Human Human +DTXSID1049011 Css NA 0.03852 mg/L PBTK NA 50% Human Human +DTXSID1049011 Css NA 0.2636 mg/L PBTK NA 95% Human Human +DTXSID1049011 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049011 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049011 Vd NA 4.851 L/kg 1compartment NA NA Rat Human +DTXSID1049011 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1049011 TK.Half.Life NA 2.143 hours 1compartment NA NA Rat Human +DTXSID1049011 Css NA 0.003351 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049011 Css NA 0.02395 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049011 Css NA 0.004906 mg/L PBTK NA 50% Rat Human +DTXSID1049011 Css NA 0.02736 mg/L PBTK NA 95% Rat Human +DTXSID1049015 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049015 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049015 Vd NA 0.4712 L/kg 1compartment NA NA Human Human +DTXSID1049015 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1049015 TK.Half.Life NA 0.7393 hours 1compartment NA NA Human Human +DTXSID1049015 Css NA 0.09865 mg/L 3compartmentss NA 50% Human Human +DTXSID1049015 Css NA 0.6683 mg/L 3compartmentss NA 95% Human Human +DTXSID1049015 Css NA 0.06632 mg/L PBTK NA 50% Human Human +DTXSID1049015 Css NA 0.4307 mg/L PBTK NA 95% Human Human +DTXSID1049015 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049015 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049015 Vd NA 0.4647 L/kg 1compartment NA NA Rat Human +DTXSID1049015 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1049015 TK.Half.Life NA 0.399 hours 1compartment NA NA Rat Human +DTXSID1049015 Css NA 0.01242 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049015 Css NA 0.06677 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049015 Css NA 0.008175 mg/L PBTK NA 50% Rat Human +DTXSID1049015 Css NA 0.04162 mg/L PBTK NA 95% Rat Human +DTXSID1049017 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049017 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049017 Vd NA 1.5 L/kg 1compartment NA NA Human Human DTXSID1049017 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049017 TK.Half.Life NA 1.575 hours 1compartment NA NA Human Human -DTXSID1049017 Css NA 0.004589 mg/L 3compartmentss NA 50% Human Human -DTXSID1049017 Css NA 0.05926 mg/L 3compartmentss NA 95% Human Human -DTXSID1049017 Css NA 0.006201 mg/L PBTK NA 50% Human Human -DTXSID1049017 Css NA 0.05508 mg/L PBTK NA 95% Human Human -DTXSID1049017 Clint NA 82.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049017 Fup NA 0.8178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049017 Vd NA 4.125 L/kg 1compartment NA NA Rat Human +DTXSID1049017 TK.Half.Life NA 1.401 hours 1compartment NA NA Human Human +DTXSID1049017 Css NA 0.03532 mg/L 3compartmentss NA 50% Human Human +DTXSID1049017 Css NA 0.3298 mg/L 3compartmentss NA 95% Human Human +DTXSID1049017 Css NA 0.03155 mg/L PBTK NA 50% Human Human +DTXSID1049017 Css NA 0.2475 mg/L PBTK NA 95% Human Human +DTXSID1049017 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049017 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049017 Vd NA 1.504 L/kg 1compartment NA NA Rat Human DTXSID1049017 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049017 TK.Half.Life NA 0.744 hours 1compartment NA NA Rat Human -DTXSID1049017 Css NA 0.002258 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049017 Css NA 0.02909 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049017 Css NA 0.003152 mg/L PBTK NA 50% Rat Human -DTXSID1049017 Css NA 0.026 mg/L PBTK NA 95% Rat Human -DTXSID1049019 Clint NA 0.3523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049019 Fup NA 0.6886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049019 Vd NA 1.901 L/kg 1compartment NA NA Human Human -DTXSID1049019 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1049019 TK.Half.Life NA 11.42 hours 1compartment NA NA Human Human -DTXSID1049019 Css NA 0.555 mg/L 3compartmentss NA 50% Human Human -DTXSID1049019 Css NA 4.241 mg/L 3compartmentss NA 95% Human Human -DTXSID1049019 Css NA 0.5544 mg/L PBTK NA 50% Human Human -DTXSID1049019 Css NA 2.908 mg/L PBTK NA 95% Human Human -DTXSID1049019 Clint NA 0.3523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049019 Fup NA 0.6886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049019 Vd NA 1.923 L/kg 1compartment NA NA Rat Human +DTXSID1049017 TK.Half.Life NA 0.7296 hours 1compartment NA NA Rat Human +DTXSID1049017 Css NA 0.004318 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049017 Css NA 0.03132 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049017 Css NA 0.003947 mg/L PBTK NA 50% Rat Human +DTXSID1049017 Css NA 0.02338 mg/L PBTK NA 95% Rat Human +DTXSID1049019 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049019 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049019 Vd NA 1.411 L/kg 1compartment NA NA Human Human +DTXSID1049019 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1049019 TK.Half.Life NA 20.37 hours 1compartment NA NA Human Human +DTXSID1049019 Css NA 1.343 mg/L 3compartmentss NA 50% Human Human +DTXSID1049019 Css NA 6.739 mg/L 3compartmentss NA 95% Human Human +DTXSID1049019 Css NA 1.162 mg/L PBTK NA 50% Human Human +DTXSID1049019 Css NA 4.524 mg/L PBTK NA 95% Human Human +DTXSID1049019 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049019 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049019 Vd NA 1.42 L/kg 1compartment NA NA Rat Human DTXSID1049019 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049019 TK.Half.Life NA 4.82 hours 1compartment NA NA Rat Human -DTXSID1049019 Css NA 0.177 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049019 Css NA 1.391 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049019 Css NA 0.1748 mg/L PBTK NA 50% Rat Human -DTXSID1049019 Css NA 0.8771 mg/L PBTK NA 95% Rat Human +DTXSID1049019 TK.Half.Life NA 6.975 hours 1compartment NA NA Rat Human +DTXSID1049019 Css NA 0.08528 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049019 Css NA 0.3767 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049019 Css NA 0.07392 mg/L PBTK NA 50% Rat Human +DTXSID1049019 Css NA 0.2457 mg/L PBTK NA 95% Rat Human DTXSID1049061 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1049061 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID1049061 Vd NA 0.4722 L/kg 1compartment NA NA Human Human DTXSID1049061 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1049061 TK.Half.Life NA 3.056 hours 1compartment NA NA Human Human -DTXSID1049061 Css NA 0.94 mg/L 3compartmentss NA 50% Human Human -DTXSID1049061 Css NA 5.75 mg/L 3compartmentss NA 95% Human Human -DTXSID1049061 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID1049061 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID1049061 Css NA 0.514 mg/L 3compartmentss NA 50% Human Human +DTXSID1049061 Css NA 3.145 mg/L 3compartmentss NA 95% Human Human +DTXSID1049061 Css NA 0.3817 mg/L PBTK NA 50% Human Human +DTXSID1049061 Css NA 1.998 mg/L PBTK NA 95% Human Human DTXSID1049061 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1049061 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID1049061 Vd NA 0.5067 L/kg 1compartment NA NA Rat Human DTXSID1049061 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1049061 TK.Half.Life NA 1.117 hours 1compartment NA NA Rat Human -DTXSID1049061 Css NA 0.2392 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049061 Css NA 1.383 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049061 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID1049061 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID1049063 Clint NA 5.366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049063 Fup NA 0.4262 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049063 Vd NA 2.377 L/kg 1compartment NA NA Human Human +DTXSID1049061 Css NA 0.002599 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049061 Css NA 0.0179 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049061 Css NA 0.001866 mg/L PBTK NA 50% Rat Human +DTXSID1049061 Css NA 0.01062 mg/L PBTK NA 95% Rat Human +DTXSID1049063 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049063 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049063 Vd NA 0.7964 L/kg 1compartment NA NA Human Human DTXSID1049063 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049063 TK.Half.Life NA 8.445 hours 1compartment NA NA Human Human -DTXSID1049063 Css NA 0.3364 mg/L 3compartmentss NA 50% Human Human -DTXSID1049063 Css NA 1.829 mg/L 3compartmentss NA 95% Human Human -DTXSID1049063 Css NA 0.2668 mg/L PBTK NA 50% Human Human -DTXSID1049063 Css NA 1.326 mg/L PBTK NA 95% Human Human -DTXSID1049063 Clint NA 5.366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049063 Fup NA 0.4262 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049063 Vd NA 1.86 L/kg 1compartment NA NA Rat Human +DTXSID1049063 TK.Half.Life NA 1.607 hours 1compartment NA NA Human Human +DTXSID1049063 Css NA 0.1307 mg/L 3compartmentss NA 50% Human Human +DTXSID1049063 Css NA 0.9389 mg/L 3compartmentss NA 95% Human Human +DTXSID1049063 Css NA 0.1084 mg/L PBTK NA 50% Human Human +DTXSID1049063 Css NA 0.6654 mg/L PBTK NA 95% Human Human +DTXSID1049063 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049063 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049063 Vd NA 0.7976 L/kg 1compartment NA NA Rat Human DTXSID1049063 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049063 TK.Half.Life NA 2.454 hours 1compartment NA NA Rat Human -DTXSID1049063 Css NA 0.1685 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049063 Css NA 0.6609 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049063 Css NA 0.1296 mg/L PBTK NA 50% Rat Human -DTXSID1049063 Css NA 0.454 mg/L PBTK NA 95% Rat Human -DTXSID1049065 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049065 Fup NA 0.087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049065 Vd NA 3.036 L/kg 1compartment NA NA Human Human +DTXSID1049063 TK.Half.Life NA 0.9132 hours 1compartment NA NA Rat Human +DTXSID1049063 Css NA 0.005557 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049063 Css NA 0.04476 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049063 Css NA 0.004656 mg/L PBTK NA 50% Rat Human +DTXSID1049063 Css NA 0.03151 mg/L PBTK NA 95% Rat Human +DTXSID1049065 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049065 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049065 Vd NA 1.986 L/kg 1compartment NA NA Human Human DTXSID1049065 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049065 TK.Half.Life NA 4.814 hours 1compartment NA NA Human Human -DTXSID1049065 Css NA 0.1169 mg/L 3compartmentss NA 50% Human Human -DTXSID1049065 Css NA 0.9387 mg/L 3compartmentss NA 95% Human Human -DTXSID1049065 Css NA 0.09564 mg/L PBTK NA 50% Human Human -DTXSID1049065 Css NA 0.69 mg/L PBTK NA 95% Human Human -DTXSID1049065 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049065 Fup NA 0.087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049065 Vd NA 2.672 L/kg 1compartment NA NA Rat Human +DTXSID1049065 TK.Half.Life NA 6.665 hours 1compartment NA NA Human Human +DTXSID1049065 Css NA 0.2718 mg/L 3compartmentss NA 50% Human Human +DTXSID1049065 Css NA 1.77 mg/L 3compartmentss NA 95% Human Human +DTXSID1049065 Css NA 0.235 mg/L PBTK NA 50% Human Human +DTXSID1049065 Css NA 1.329 mg/L PBTK NA 95% Human Human +DTXSID1049065 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049065 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049065 Vd NA 1.98 L/kg 1compartment NA NA Rat Human DTXSID1049065 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049065 TK.Half.Life NA 1.913 hours 1compartment NA NA Rat Human -DTXSID1049065 Css NA 0.06524 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049065 Css NA 0.4338 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049065 Css NA 0.05109 mg/L PBTK NA 50% Rat Human -DTXSID1049065 Css NA 0.3035 mg/L PBTK NA 95% Rat Human -DTXSID1049067 Clint NA 34.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049067 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049067 Vd NA 2.146 L/kg 1compartment NA NA Human Human +DTXSID1049065 TK.Half.Life NA 3.945 hours 1compartment NA NA Rat Human +DTXSID1049065 Css NA 0.03233 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049065 Css NA 0.1519 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049065 Css NA 0.02814 mg/L PBTK NA 50% Rat Human +DTXSID1049065 Css NA 0.1101 mg/L PBTK NA 95% Rat Human +DTXSID1049067 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049067 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049067 Vd NA 1.785 L/kg 1compartment NA NA Human Human DTXSID1049067 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049067 TK.Half.Life NA 11.48 hours 1compartment NA NA Human Human -DTXSID1049067 Css NA 0.725 mg/L 3compartmentss NA 50% Human Human -DTXSID1049067 Css NA 5.689 mg/L 3compartmentss NA 95% Human Human -DTXSID1049067 Css NA 0.471 mg/L PBTK NA 50% Human Human -DTXSID1049067 Css NA 3.571 mg/L PBTK NA 95% Human Human -DTXSID1049067 Clint NA 34.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049067 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049067 Vd NA 1.602 L/kg 1compartment NA NA Rat Human +DTXSID1049067 TK.Half.Life NA 4.81 hours 1compartment NA NA Human Human +DTXSID1049067 Css NA 0.2737 mg/L 3compartmentss NA 50% Human Human +DTXSID1049067 Css NA 1.99 mg/L 3compartmentss NA 95% Human Human +DTXSID1049067 Css NA 0.1851 mg/L PBTK NA 50% Human Human +DTXSID1049067 Css NA 1.272 mg/L PBTK NA 95% Human Human +DTXSID1049067 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049067 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049067 Vd NA 1.365 L/kg 1compartment NA NA Rat Human DTXSID1049067 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049067 TK.Half.Life NA 3.52 hours 1compartment NA NA Rat Human -DTXSID1049067 Css NA 0.41 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049067 Css NA 2.571 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049067 Css NA 0.2535 mg/L PBTK NA 50% Rat Human -DTXSID1049067 Css NA 1.526 mg/L PBTK NA 95% Rat Human +DTXSID1049067 TK.Half.Life NA 1.73 hours 1compartment NA NA Rat Human +DTXSID1049067 Css NA 0.0352 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049067 Css NA 0.2025 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049067 Css NA 0.0236 mg/L PBTK NA 50% Rat Human +DTXSID1049067 Css NA 0.1275 mg/L PBTK NA 95% Rat Human DTXSID1049069 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1049069 Fup NA 0.2049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049069 Vd NA 0.2608 L/kg 1compartment NA NA Human Human +DTXSID1049069 Vd NA 0.257 L/kg 1compartment NA NA Human Human DTXSID1049069 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049069 TK.Half.Life NA 8.236 hours 1compartment NA NA Human Human -DTXSID1049069 Css NA 4.065 mg/L 3compartmentss NA 50% Human Human -DTXSID1049069 Css NA 14.6 mg/L 3compartmentss NA 95% Human Human -DTXSID1049069 Css NA 2.547 mg/L PBTK NA 50% Human Human -DTXSID1049069 Css NA 8.725 mg/L PBTK NA 95% Human Human +DTXSID1049069 TK.Half.Life NA 8.116 hours 1compartment NA NA Human Human +DTXSID1049069 Css NA 3.438 mg/L 3compartmentss NA 50% Human Human +DTXSID1049069 Css NA 12.54 mg/L 3compartmentss NA 95% Human Human +DTXSID1049069 Css NA 2.167 mg/L PBTK NA 50% Human Human +DTXSID1049069 Css NA 7.497 mg/L PBTK NA 95% Human Human DTXSID1049069 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1049069 Fup NA 0.2049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049069 Vd NA 0.2663 L/kg 1compartment NA NA Rat Human +DTXSID1049069 Vd NA 0.2631 L/kg 1compartment NA NA Rat Human DTXSID1049069 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049069 TK.Half.Life NA 2.865 hours 1compartment NA NA Rat Human -DTXSID1049069 Css NA 1.141 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049069 Css NA 3.321 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049069 Css NA 0.6755 mg/L PBTK NA 50% Rat Human -DTXSID1049069 Css NA 1.856 mg/L PBTK NA 95% Rat Human -DTXSID1049221 Clint NA 18.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049221 Fup NA 0.0489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049221 Vd NA 1.465 L/kg 1compartment NA NA Human Human +DTXSID1049069 TK.Half.Life NA 2.831 hours 1compartment NA NA Rat Human +DTXSID1049069 Css NA 0.06236 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049069 Css NA 0.3572 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049069 Css NA 0.03736 mg/L PBTK NA 50% Rat Human +DTXSID1049069 Css NA 0.2064 mg/L PBTK NA 95% Rat Human +DTXSID1049221 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049221 Fup 0.065 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049221 Vd NA 1.946 L/kg 1compartment NA NA Human Human DTXSID1049221 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049221 TK.Half.Life NA 7.83 hours 1compartment NA NA Human Human -DTXSID1049221 Css NA 0.7605 mg/L 3compartmentss NA 50% Human Human -DTXSID1049221 Css NA 6.033 mg/L 3compartmentss NA 95% Human Human -DTXSID1049221 Css NA 0.4874 mg/L PBTK NA 50% Human Human -DTXSID1049221 Css NA 3.677 mg/L PBTK NA 95% Human Human -DTXSID1049221 Clint NA 18.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049221 Fup NA 0.0489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049221 Vd NA 1.101 L/kg 1compartment NA NA Rat Human +DTXSID1049221 TK.Half.Life NA 8.586 hours 1compartment NA NA Human Human +DTXSID1049221 Css NA 0.5324 mg/L 3compartmentss NA 50% Human Human +DTXSID1049221 Css NA 3.519 mg/L 3compartmentss NA 95% Human Human +DTXSID1049221 Css NA 0.3514 mg/L PBTK NA 50% Human Human +DTXSID1049221 Css NA 2.239 mg/L PBTK NA 95% Human Human +DTXSID1049221 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049221 Fup 0.065 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049221 Vd NA 1.464 L/kg 1compartment NA NA Rat Human DTXSID1049221 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049221 TK.Half.Life NA 3.052 hours 1compartment NA NA Rat Human -DTXSID1049221 Css NA 0.4214 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049221 Css NA 2.558 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049221 Css NA 0.2536 mg/L PBTK NA 50% Rat Human -DTXSID1049221 Css NA 1.454 mg/L PBTK NA 95% Rat Human -DTXSID1049223 Clint NA 8.194 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049223 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049223 Vd NA 1.928 L/kg 1compartment NA NA Human Human -DTXSID1049223 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1049223 TK.Half.Life NA 16.44 hours 1compartment NA NA Human Human -DTXSID1049223 Css NA 1.191 mg/L 3compartmentss NA 50% Human Human -DTXSID1049223 Css NA 7.569 mg/L 3compartmentss NA 95% Human Human -DTXSID1049223 Css NA 0.7904 mg/L PBTK NA 50% Human Human -DTXSID1049223 Css NA 4.773 mg/L PBTK NA 95% Human Human -DTXSID1049223 Clint NA 8.194 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049223 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049223 Vd NA 1.455 L/kg 1compartment NA NA Rat Human +DTXSID1049221 TK.Half.Life NA 2.875 hours 1compartment NA NA Rat Human +DTXSID1049221 Css NA 0.06824 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049221 Css NA 0.3781 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049221 Css NA 0.04432 mg/L PBTK NA 50% Rat Human +DTXSID1049221 Css NA 0.2359 mg/L PBTK NA 95% Rat Human +DTXSID1049223 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049223 Fup 0.0704 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049223 Vd NA 1.855 L/kg 1compartment NA NA Human Human +DTXSID1049223 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1049223 TK.Half.Life NA 7.48 hours 1compartment NA NA Human Human +DTXSID1049223 Css NA 0.4766 mg/L 3compartmentss NA 50% Human Human +DTXSID1049223 Css NA 3.4 mg/L 3compartmentss NA 95% Human Human +DTXSID1049223 Css NA 0.3151 mg/L PBTK NA 50% Human Human +DTXSID1049223 Css NA 2.136 mg/L PBTK NA 95% Human Human +DTXSID1049223 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049223 Fup 0.0704 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049223 Vd NA 1.399 L/kg 1compartment NA NA Rat Human DTXSID1049223 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049223 TK.Half.Life NA 5.432 hours 1compartment NA NA Rat Human -DTXSID1049223 Css NA 0.6365 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049223 Css NA 2.99 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049223 Css NA 0.4025 mg/L PBTK NA 50% Rat Human -DTXSID1049223 Css NA 1.778 mg/L PBTK NA 95% Rat Human -DTXSID1049225 Clint NA 54.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049225 Fup NA 0.2356 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049225 Vd NA 0.3552 L/kg 1compartment NA NA Human Human +DTXSID1049223 TK.Half.Life NA 2.595 hours 1compartment NA NA Rat Human +DTXSID1049223 Css NA 0.06198 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049223 Css NA 0.3343 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049223 Css NA 0.04009 mg/L PBTK NA 50% Rat Human +DTXSID1049223 Css NA 0.2075 mg/L PBTK NA 95% Rat Human +DTXSID1049225 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049225 Fup 0.275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049225 Vd NA 0.3815 L/kg 1compartment NA NA Human Human DTXSID1049225 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049225 TK.Half.Life NA 0.3963 hours 1compartment NA NA Human Human -DTXSID1049225 Css NA 0.03991 mg/L 3compartmentss NA 50% Human Human -DTXSID1049225 Css NA 0.2848 mg/L 3compartmentss NA 95% Human Human -DTXSID1049225 Css NA 0.02654 mg/L PBTK NA 50% Human Human -DTXSID1049225 Css NA 0.1808 mg/L PBTK NA 95% Human Human -DTXSID1049225 Clint NA 54.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049225 Fup NA 0.2356 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049225 Vd NA 0.3546 L/kg 1compartment NA NA Rat Human +DTXSID1049225 TK.Half.Life NA 1.048 hours 1compartment NA NA Human Human +DTXSID1049225 Css NA 0.2532 mg/L 3compartmentss NA 50% Human Human +DTXSID1049225 Css NA 1.586 mg/L 3compartmentss NA 95% Human Human +DTXSID1049225 Css NA 0.1723 mg/L PBTK NA 50% Human Human +DTXSID1049225 Css NA 1.003 mg/L PBTK NA 95% Human Human +DTXSID1049225 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049225 Fup 0.275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049225 Vd NA 0.3811 L/kg 1compartment NA NA Rat Human DTXSID1049225 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049225 TK.Half.Life NA 0.197 hours 1compartment NA NA Rat Human -DTXSID1049225 Css NA 0.02237 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049225 Css NA 0.1272 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049225 Css NA 0.0141 mg/L PBTK NA 50% Rat Human -DTXSID1049225 Css NA 0.07626 mg/L PBTK NA 95% Rat Human -DTXSID1049227 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049227 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049227 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID1049227 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1049227 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID1049227 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID1049227 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID1049227 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID1049227 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID1049227 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049227 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049227 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID1049227 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049227 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID1049227 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049227 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049227 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID1049227 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID1049229 Clint NA 168.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049229 Fup NA 0.342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049229 Vd NA 3.142 L/kg 1compartment NA NA Human Human -DTXSID1049229 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049229 TK.Half.Life NA 12.61 hours 1compartment NA NA Human Human -DTXSID1049229 Css NA 0.394 mg/L 3compartmentss NA 50% Human Human -DTXSID1049229 Css NA 2.582 mg/L 3compartmentss NA 95% Human Human -DTXSID1049229 Css NA 0.2758 mg/L PBTK NA 50% Human Human -DTXSID1049229 Css NA 1.728 mg/L PBTK NA 95% Human Human -DTXSID1049229 Clint NA 168.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049229 Fup NA 0.342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049229 Vd NA 2.357 L/kg 1compartment NA NA Rat Human -DTXSID1049229 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049229 TK.Half.Life NA 2.109 hours 1compartment NA NA Rat Human -DTXSID1049229 Css NA 0.2207 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049229 Css NA 1.176 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049229 Css NA 0.1469 mg/L PBTK NA 50% Rat Human -DTXSID1049229 Css NA 0.7692 mg/L PBTK NA 95% Rat Human -DTXSID1049271 Clint NA 22.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049271 Fup NA 0.0209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049271 Vd NA 3 L/kg 1compartment NA NA Human Human -DTXSID1049271 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID1049271 TK.Half.Life NA 58.84 hours 1compartment NA NA Human Human -DTXSID1049271 Css NA 2.486 mg/L 3compartmentss NA 50% Human Human -DTXSID1049271 Css NA 16.61 mg/L 3compartmentss NA 95% Human Human -DTXSID1049271 Css NA 1.711 mg/L PBTK NA 50% Human Human -DTXSID1049271 Css NA 11.14 mg/L PBTK NA 95% Human Human -DTXSID1049271 Clint NA 22.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049271 Fup NA 0.0209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049271 Vd NA 2.246 L/kg 1compartment NA NA Rat Human -DTXSID1049271 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1049271 TK.Half.Life NA 9.373 hours 1compartment NA NA Rat Human -DTXSID1049271 Css NA 1.407 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049271 Css NA 7.331 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049271 Css NA 0.9186 mg/L PBTK NA 50% Rat Human -DTXSID1049271 Css NA 4.665 mg/L PBTK NA 95% Rat Human -DTXSID1049273 Clint NA 24.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049273 Fup NA 0.0377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049273 Vd NA 3.106 L/kg 1compartment NA NA Human Human -DTXSID1049273 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID1049273 TK.Half.Life NA 66.65 hours 1compartment NA NA Human Human -DTXSID1049273 Css NA 2.585 mg/L 3compartmentss NA 50% Human Human -DTXSID1049273 Css NA 16.87 mg/L 3compartmentss NA 95% Human Human -DTXSID1049273 Css NA 1.797 mg/L PBTK NA 50% Human Human -DTXSID1049273 Css NA 11.17 mg/L PBTK NA 95% Human Human -DTXSID1049273 Clint NA 24.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049273 Fup NA 0.0377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049273 Vd NA 2.328 L/kg 1compartment NA NA Rat Human -DTXSID1049273 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID1049273 TK.Half.Life NA 9.29 hours 1compartment NA NA Rat Human -DTXSID1049273 Css NA 1.448 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049273 Css NA 7.565 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049273 Css NA 0.9632 mg/L PBTK NA 50% Rat Human -DTXSID1049273 Css NA 4.833 mg/L PBTK NA 95% Rat Human -DTXSID1049277 Clint NA 7.731 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049277 Fup NA 0.1912 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049277 Vd NA 1.529 L/kg 1compartment NA NA Human Human -DTXSID1049277 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049277 TK.Half.Life NA 5.576 hours 1compartment NA NA Human Human -DTXSID1049277 Css NA 0.3651 mg/L 3compartmentss NA 50% Human Human -DTXSID1049277 Css NA 2.122 mg/L 3compartmentss NA 95% Human Human -DTXSID1049277 Css NA 0.261 mg/L PBTK NA 50% Human Human -DTXSID1049277 Css NA 1.415 mg/L PBTK NA 95% Human Human -DTXSID1049277 Clint NA 7.731 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049277 Fup NA 0.1912 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049277 Vd NA 1.201 L/kg 1compartment NA NA Rat Human -DTXSID1049277 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049277 TK.Half.Life NA 2.191 hours 1compartment NA NA Rat Human -DTXSID1049277 Css NA 0.1898 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049277 Css NA 0.8131 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049277 Css NA 0.1301 mg/L PBTK NA 50% Rat Human -DTXSID1049277 Css NA 0.5186 mg/L PBTK NA 95% Rat Human -DTXSID1049304 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049304 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049304 Vd NA 534100 L/kg 1compartment NA NA Human Human -DTXSID1049304 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID1049304 TK.Half.Life NA 504100 hours 1compartment NA NA Human Human -DTXSID1049304 Css NA 7.28e-07 mg/L 3compartmentss NA 50% Human Human -DTXSID1049304 Css NA 4.386e-06 mg/L 3compartmentss NA 95% Human Human -DTXSID1049304 Css NA 0.07869 mg/L PBTK NA 50% Human Human -DTXSID1049304 Css NA 0.4336 mg/L PBTK NA 95% Human Human -DTXSID1049304 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049304 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049304 Vd NA 509800 L/kg 1compartment NA NA Rat Human -DTXSID1049304 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID1049304 TK.Half.Life NA 88300 hours 1compartment NA NA Rat Human -DTXSID1049304 Css NA 3.67e-07 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049304 Css NA 1.636e-06 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049304 Css NA 0.04275 mg/L PBTK NA 50% Rat Human -DTXSID1049304 Css NA 0.1912 mg/L PBTK NA 95% Rat Human -DTXSID1049306 Clint NA 2.036 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049306 Fup NA 0.1536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049306 Vd NA 1.032 L/kg 1compartment NA NA Human Human -DTXSID1049306 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1049306 TK.Half.Life NA 11.13 hours 1compartment NA NA Human Human -DTXSID1049306 Css NA 1.442 mg/L 3compartmentss NA 50% Human Human -DTXSID1049306 Css NA 7.71 mg/L 3compartmentss NA 95% Human Human -DTXSID1049306 Css NA 0.9723 mg/L PBTK NA 50% Human Human -DTXSID1049306 Css NA 4.737 mg/L PBTK NA 95% Human Human -DTXSID1049306 Clint NA 2.036 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049306 Fup NA 0.1536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049306 Vd NA 0.8317 L/kg 1compartment NA NA Rat Human +DTXSID1049225 TK.Half.Life NA 0.6006 hours 1compartment NA NA Rat Human +DTXSID1049225 Css NA 0.03016 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049225 Css NA 0.1362 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049225 Css NA 0.02024 mg/L PBTK NA 50% Rat Human +DTXSID1049225 Css NA 0.08372 mg/L PBTK NA 95% Rat Human +DTXSID1049271 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049271 Fup 0.0135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049271 Vd NA 2.642 L/kg 1compartment NA NA Human Human +DTXSID1049271 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID1049271 TK.Half.Life NA 43.46 hours 1compartment NA NA Human Human +DTXSID1049271 Css NA 2.26 mg/L 3compartmentss NA 50% Human Human +DTXSID1049271 Css NA 16.65 mg/L 3compartmentss NA 95% Human Human +DTXSID1049271 Css NA 1.512 mg/L PBTK NA 50% Human Human +DTXSID1049271 Css NA 10.57 mg/L PBTK NA 95% Human Human +DTXSID1049271 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049271 Fup 0.0135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049271 Vd NA 1.972 L/kg 1compartment NA NA Rat Human +DTXSID1049271 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID1049271 TK.Half.Life NA 9.653 hours 1compartment NA NA Rat Human +DTXSID1049271 Css NA 0.2889 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049271 Css NA 1.808 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049271 Css NA 0.1893 mg/L PBTK NA 50% Rat Human +DTXSID1049271 Css NA 1.154 mg/L PBTK NA 95% Rat Human +DTXSID1049273 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049273 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049273 Vd NA 3.113 L/kg 1compartment NA NA Human Human +DTXSID1049273 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID1049273 TK.Half.Life NA 84.55 hours 1compartment NA NA Human Human +DTXSID1049273 Css NA 1.775 mg/L 3compartmentss NA 50% Human Human +DTXSID1049273 Css NA 11.96 mg/L 3compartmentss NA 95% Human Human +DTXSID1049273 Css NA 1.239 mg/L PBTK NA 50% Human Human +DTXSID1049273 Css NA 8.023 mg/L PBTK NA 95% Human Human +DTXSID1049273 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049273 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049273 Vd NA 2.332 L/kg 1compartment NA NA Rat Human +DTXSID1049273 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID1049273 TK.Half.Life NA 11.54 hours 1compartment NA NA Rat Human +DTXSID1049273 Css NA 0.01937 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049273 Css NA 0.1233 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049273 Css NA 0.01285 mg/L PBTK NA 50% Rat Human +DTXSID1049273 Css NA 0.08126 mg/L PBTK NA 95% Rat Human +DTXSID1049277 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049277 Fup 0.0952 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049277 Vd NA 5.251 L/kg 1compartment NA NA Human Human +DTXSID1049277 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID1049277 TK.Half.Life NA 156.8 hours 1compartment NA NA Human Human +DTXSID1049277 Css NA 2.794 mg/L 3compartmentss NA 50% Human Human +DTXSID1049277 Css NA 16.3 mg/L 3compartmentss NA 95% Human Human +DTXSID1049277 Css NA 2.32 mg/L PBTK NA 50% Human Human +DTXSID1049277 Css NA 13.19 mg/L PBTK NA 95% Human Human +DTXSID1049277 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049277 Fup 0.0952 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049277 Vd NA 4.018 L/kg 1compartment NA NA Rat Human +DTXSID1049277 Days.Css NA 17 Days PBTK NA NA Rat Human +DTXSID1049277 TK.Half.Life NA 20.89 hours 1compartment NA NA Rat Human +DTXSID1049277 Css NA 0.3655 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049277 Css NA 1.783 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049277 Css NA 0.3046 mg/L PBTK NA 50% Rat Human +DTXSID1049277 Css NA 1.55 mg/L PBTK NA 95% Rat Human +DTXSID1049306 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049306 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049306 Vd NA 1.247 L/kg 1compartment NA NA Human Human +DTXSID1049306 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1049306 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human +DTXSID1049306 Css NA 0.6772 mg/L 3compartmentss NA 50% Human Human +DTXSID1049306 Css NA 4.484 mg/L 3compartmentss NA 95% Human Human +DTXSID1049306 Css NA 0.455 mg/L PBTK NA 50% Human Human +DTXSID1049306 Css NA 2.774 mg/L PBTK NA 95% Human Human +DTXSID1049306 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049306 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049306 Vd NA 0.9789 L/kg 1compartment NA NA Rat Human DTXSID1049306 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049306 TK.Half.Life NA 4.569 hours 1compartment NA NA Rat Human -DTXSID1049306 Css NA 0.6652 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049306 Css NA 2.743 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049306 Css NA 0.4262 mg/L PBTK NA 50% Rat Human -DTXSID1049306 Css NA 1.573 mg/L PBTK NA 95% Rat Human -DTXSID1049308 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049308 Fup NA 0.9175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049308 Vd NA 1.229 L/kg 1compartment NA NA Human Human -DTXSID1049308 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049308 TK.Half.Life NA 9.107 hours 1compartment NA NA Human Human -DTXSID1049308 Css NA 0.8076 mg/L 3compartmentss NA 50% Human Human -DTXSID1049308 Css NA 3.202 mg/L 3compartmentss NA 95% Human Human -DTXSID1049308 Css NA 0.739 mg/L PBTK NA 50% Human Human -DTXSID1049308 Css NA 2.321 mg/L PBTK NA 95% Human Human -DTXSID1049308 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049308 Fup NA 0.9175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049308 Vd NA 1.166 L/kg 1compartment NA NA Rat Human +DTXSID1049306 TK.Half.Life NA 2.801 hours 1compartment NA NA Rat Human +DTXSID1049306 Css NA 0.08204 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049306 Css NA 0.4041 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049306 Css NA 0.05402 mg/L PBTK NA 50% Rat Human +DTXSID1049306 Css NA 0.2468 mg/L PBTK NA 95% Rat Human +DTXSID1049308 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049308 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049308 Vd NA 0.891 L/kg 1compartment NA NA Human Human +DTXSID1049308 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1049308 TK.Half.Life NA 9.995 hours 1compartment NA NA Human Human +DTXSID1049308 Css NA 1.046 mg/L 3compartmentss NA 50% Human Human +DTXSID1049308 Css NA 7.473 mg/L 3compartmentss NA 95% Human Human +DTXSID1049308 Css NA 0.8634 mg/L PBTK NA 50% Human Human +DTXSID1049308 Css NA 4.678 mg/L PBTK NA 95% Human Human +DTXSID1049308 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049308 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049308 Vd NA 0.8531 L/kg 1compartment NA NA Rat Human DTXSID1049308 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049308 TK.Half.Life NA 2.836 hours 1compartment NA NA Rat Human -DTXSID1049308 Css NA 0.2074 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049308 Css NA 0.7746 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049308 Css NA 0.187 mg/L PBTK NA 50% Rat Human -DTXSID1049308 Css NA 0.5191 mg/L PBTK NA 95% Rat Human -DTXSID1049352 Clint NA 108.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049352 Fup NA 0.0793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049352 Vd NA 6.184 L/kg 1compartment NA NA Human Human -DTXSID1049352 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049352 TK.Half.Life NA 12.89 hours 1compartment NA NA Human Human -DTXSID1049352 Css NA 0.1413 mg/L 3compartmentss NA 50% Human Human -DTXSID1049352 Css NA 0.9256 mg/L 3compartmentss NA 95% Human Human -DTXSID1049352 Css NA 0.1267 mg/L PBTK NA 50% Human Human -DTXSID1049352 Css NA 0.7799 mg/L PBTK NA 95% Human Human -DTXSID1049352 Clint NA 108.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049352 Fup NA 0.0793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049352 Vd NA 4.782 L/kg 1compartment NA NA Rat Human -DTXSID1049352 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049352 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human -DTXSID1049352 Css NA 0.07747 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049352 Css NA 0.4415 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049352 Css NA 0.06849 mg/L PBTK NA 50% Rat Human -DTXSID1049352 Css NA 0.3611 mg/L PBTK NA 95% Rat Human -DTXSID1049354 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049354 Fup NA 0.0233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049354 Vd NA 0.5899 L/kg 1compartment NA NA Human Human -DTXSID1049354 Days.Css NA 39 Days PBTK NA NA Human Human -DTXSID1049354 TK.Half.Life NA 170.1 hours 1compartment NA NA Human Human -DTXSID1049354 Css NA 46.24 mg/L 3compartmentss NA 50% Human Human -DTXSID1049354 Css NA 290.3 mg/L 3compartmentss NA 95% Human Human -DTXSID1049354 Css NA 29.24 mg/L PBTK NA 50% Human Human -DTXSID1049354 Css NA 170.5 mg/L PBTK NA 95% Human Human -DTXSID1049354 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049354 Fup NA 0.0233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049354 Vd NA 0.4926 L/kg 1compartment NA NA Rat Human -DTXSID1049354 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID1049354 TK.Half.Life NA 47.02 hours 1compartment NA NA Rat Human -DTXSID1049354 Css NA 13.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049354 Css NA 70.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049354 Css NA 7.742 mg/L PBTK NA 50% Rat Human -DTXSID1049354 Css NA 38.86 mg/L PBTK NA 95% Rat Human -DTXSID1049358 Clint NA 0.1128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049358 Fup NA 0.7117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049358 Vd NA 0.9425 L/kg 1compartment NA NA Human Human -DTXSID1049358 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049358 TK.Half.Life NA 7.367 hours 1compartment NA NA Human Human -DTXSID1049358 Css NA 0.8513 mg/L 3compartmentss NA 50% Human Human -DTXSID1049358 Css NA 5.578 mg/L 3compartmentss NA 95% Human Human -DTXSID1049358 Css NA 0.7258 mg/L PBTK NA 50% Human Human -DTXSID1049358 Css NA 3.601 mg/L PBTK NA 95% Human Human -DTXSID1049358 Clint NA 0.1128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049358 Fup NA 0.7117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049358 Vd NA 0.9193 L/kg 1compartment NA NA Rat Human -DTXSID1049358 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049358 TK.Half.Life NA 2.624 hours 1compartment NA NA Rat Human -DTXSID1049358 Css NA 0.2412 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049358 Css NA 1.66 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049358 Css NA 0.2001 mg/L PBTK NA 50% Rat Human -DTXSID1049358 Css NA 0.9948 mg/L PBTK NA 95% Rat Human -DTXSID1049431 Clint NA 4.341 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049431 Fup NA 0.075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049431 Vd NA 2.564 L/kg 1compartment NA NA Human Human -DTXSID1049431 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID1049431 TK.Half.Life NA 61.02 hours 1compartment NA NA Human Human -DTXSID1049431 Css NA 3.237 mg/L 3compartmentss NA 50% Human Human -DTXSID1049431 Css NA 16.71 mg/L 3compartmentss NA 95% Human Human -DTXSID1049431 Css NA 2.211 mg/L PBTK NA 50% Human Human -DTXSID1049431 Css NA 11.02 mg/L PBTK NA 95% Human Human -DTXSID1049431 Clint NA 4.341 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049431 Fup NA 0.075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049431 Vd NA 1.927 L/kg 1compartment NA NA Rat Human -DTXSID1049431 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1049431 TK.Half.Life NA 13.68 hours 1compartment NA NA Rat Human -DTXSID1049431 Css NA 1.687 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049431 Css NA 6.294 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049431 Css NA 1.099 mg/L PBTK NA 50% Rat Human -DTXSID1049431 Css NA 3.872 mg/L PBTK NA 95% Rat Human -DTXSID1049433 Clint NA 0.9665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049433 Fup NA 0.7579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049433 Vd NA 1.002 L/kg 1compartment NA NA Human Human +DTXSID1049308 TK.Half.Life NA 3.202 hours 1compartment NA NA Rat Human +DTXSID1049308 Css NA 0.01965 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049308 Css NA 0.1741 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049308 Css NA 0.01564 mg/L PBTK NA 50% Rat Human +DTXSID1049308 Css NA 0.1127 mg/L PBTK NA 95% Rat Human +DTXSID1049354 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049354 Fup 0.0294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049354 Vd NA 0.5959 L/kg 1compartment NA NA Human Human +DTXSID1049354 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1049354 TK.Half.Life NA 3.853 hours 1compartment NA NA Human Human +DTXSID1049354 Css NA 0.9682 mg/L 3compartmentss NA 50% Human Human +DTXSID1049354 Css NA 9.928 mg/L 3compartmentss NA 95% Human Human +DTXSID1049354 Css NA 0.6192 mg/L PBTK NA 50% Human Human +DTXSID1049354 Css NA 5.974 mg/L PBTK NA 95% Human Human +DTXSID1049354 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049354 Fup 0.0294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049354 Vd NA 0.5055 L/kg 1compartment NA NA Rat Human +DTXSID1049354 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1049354 TK.Half.Life NA 2.071 hours 1compartment NA NA Rat Human +DTXSID1049354 Css NA 0.1274 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049354 Css NA 1.01 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049354 Css NA 0.07932 mg/L PBTK NA 50% Rat Human +DTXSID1049354 Css NA 0.5845 mg/L PBTK NA 95% Rat Human +DTXSID1049431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049431 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049431 Vd NA 2.174 L/kg 1compartment NA NA Human Human +DTXSID1049431 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1049431 TK.Half.Life NA 15.6 hours 1compartment NA NA Human Human +DTXSID1049431 Css NA 0.9808 mg/L 3compartmentss NA 50% Human Human +DTXSID1049431 Css NA 7.46 mg/L 3compartmentss NA 95% Human Human +DTXSID1049431 Css NA 0.6395 mg/L PBTK NA 50% Human Human +DTXSID1049431 Css NA 4.714 mg/L PBTK NA 95% Human Human +DTXSID1049431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049431 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049431 Vd NA 1.624 L/kg 1compartment NA NA Rat Human +DTXSID1049431 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1049431 TK.Half.Life NA 4.683 hours 1compartment NA NA Rat Human +DTXSID1049431 Css NA 0.1286 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049431 Css NA 0.7526 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049431 Css NA 0.08247 mg/L PBTK NA 50% Rat Human +DTXSID1049431 Css NA 0.4655 mg/L PBTK NA 95% Rat Human +DTXSID1049433 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049433 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1049433 Vd NA 0.6581 L/kg 1compartment NA NA Human Human DTXSID1049433 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1049433 TK.Half.Life NA 3.606 hours 1compartment NA NA Human Human -DTXSID1049433 Css NA 0.3874 mg/L 3compartmentss NA 50% Human Human -DTXSID1049433 Css NA 2.646 mg/L 3compartmentss NA 95% Human Human -DTXSID1049433 Css NA 0.3314 mg/L PBTK NA 50% Human Human -DTXSID1049433 Css NA 1.726 mg/L PBTK NA 95% Human Human -DTXSID1049433 Clint NA 0.9665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049433 Fup NA 0.7579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049433 Vd NA 0.9529 L/kg 1compartment NA NA Rat Human +DTXSID1049433 TK.Half.Life NA 1.429 hours 1compartment NA NA Human Human +DTXSID1049433 Css NA 0.1788 mg/L 3compartmentss NA 50% Human Human +DTXSID1049433 Css NA 1.157 mg/L 3compartmentss NA 95% Human Human +DTXSID1049433 Css NA 0.131 mg/L PBTK NA 50% Human Human +DTXSID1049433 Css NA 0.7701 mg/L PBTK NA 95% Human Human +DTXSID1049433 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049433 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1049433 Vd NA 0.6227 L/kg 1compartment NA NA Rat Human DTXSID1049433 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1049433 TK.Half.Life NA 1.613 hours 1compartment NA NA Rat Human -DTXSID1049433 Css NA 0.146 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049433 Css NA 0.9712 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049433 Css NA 0.1226 mg/L PBTK NA 50% Rat Human -DTXSID1049433 Css NA 0.5836 mg/L PBTK NA 95% Rat Human -DTXSID1049697 Clint NA 59.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049697 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1049697 Vd NA 3.118 L/kg 1compartment NA NA Human Human -DTXSID1049697 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1049697 TK.Half.Life NA 33.42 hours 1compartment NA NA Human Human -DTXSID1049697 Css NA 1.219 mg/L 3compartmentss NA 50% Human Human -DTXSID1049697 Css NA 7.647 mg/L 3compartmentss NA 95% Human Human -DTXSID1049697 Css NA 0.846 mg/L PBTK NA 50% Human Human -DTXSID1049697 Css NA 5.179 mg/L PBTK NA 95% Human Human -DTXSID1049697 Clint NA 59.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049697 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1049697 Vd NA 2.337 L/kg 1compartment NA NA Rat Human -DTXSID1049697 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1049697 TK.Half.Life NA 4.83 hours 1compartment NA NA Rat Human -DTXSID1049697 Css NA 0.693 mg/L 3compartmentss NA 50% Rat Human -DTXSID1049697 Css NA 3.389 mg/L 3compartmentss NA 95% Rat Human -DTXSID1049697 Css NA 0.4584 mg/L PBTK NA 50% Rat Human -DTXSID1049697 Css NA 2.178 mg/L PBTK NA 95% Rat Human -DTXSID1051690 Clint NA 14.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051690 Fup NA 0.6836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051690 Vd NA 1.695 L/kg 1compartment NA NA Human Human +DTXSID1049433 TK.Half.Life NA 0.7543 hours 1compartment NA NA Rat Human +DTXSID1049433 Css NA 0.02088 mg/L 3compartmentss NA 50% Rat Human +DTXSID1049433 Css NA 0.1034 mg/L 3compartmentss NA 95% Rat Human +DTXSID1049433 Css NA 0.0153 mg/L PBTK NA 50% Rat Human +DTXSID1049433 Css NA 0.06577 mg/L PBTK NA 95% Rat Human +DTXSID1051690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051690 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051690 Vd NA 1.077 L/kg 1compartment NA NA Human Human DTXSID1051690 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1051690 TK.Half.Life NA 1.7 hours 1compartment NA NA Human Human -DTXSID1051690 Css NA 0.04988 mg/L 3compartmentss NA 50% Human Human -DTXSID1051690 Css NA 0.5101 mg/L 3compartmentss NA 95% Human Human -DTXSID1051690 Css NA 0.04478 mg/L PBTK NA 50% Human Human -DTXSID1051690 Css NA 0.3698 mg/L PBTK NA 95% Human Human -DTXSID1051690 Clint NA 14.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051690 Fup NA 0.6836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051690 Vd NA 1.448 L/kg 1compartment NA NA Rat Human +DTXSID1051690 TK.Half.Life NA 1.437 hours 1compartment NA NA Human Human +DTXSID1051690 Css NA 0.07151 mg/L 3compartmentss NA 50% Human Human +DTXSID1051690 Css NA 0.5282 mg/L 3compartmentss NA 95% Human Human +DTXSID1051690 Css NA 0.05324 mg/L PBTK NA 50% Human Human +DTXSID1051690 Css NA 0.3654 mg/L PBTK NA 95% Human Human +DTXSID1051690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051690 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051690 Vd NA 0.9114 L/kg 1compartment NA NA Rat Human DTXSID1051690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1051690 TK.Half.Life NA 0.6911 hours 1compartment NA NA Rat Human -DTXSID1051690 Css NA 0.02549 mg/L 3compartmentss NA 50% Rat Human -DTXSID1051690 Css NA 0.2175 mg/L 3compartmentss NA 95% Rat Human -DTXSID1051690 Css NA 0.02235 mg/L PBTK NA 50% Rat Human -DTXSID1051690 Css NA 0.1443 mg/L PBTK NA 95% Rat Human -DTXSID1051808 Clint NA 9.304 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051808 Fup NA 0.5663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051808 Vd NA 0.942 L/kg 1compartment NA NA Human Human -DTXSID1051808 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1051808 TK.Half.Life NA 1.2 hours 1compartment NA NA Human Human -DTXSID1051808 Css NA 0.0828 mg/L 3compartmentss NA 50% Human Human -DTXSID1051808 Css NA 0.8058 mg/L 3compartmentss NA 95% Human Human -DTXSID1051808 Css NA 0.06743 mg/L PBTK NA 50% Human Human -DTXSID1051808 Css NA 0.5437 mg/L PBTK NA 95% Human Human -DTXSID1051808 Clint NA 9.304 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051808 Fup NA 0.5663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051808 Vd NA 0.8858 L/kg 1compartment NA NA Rat Human -DTXSID1051808 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1051808 TK.Half.Life NA 0.5955 hours 1compartment NA NA Rat Human -DTXSID1051808 Css NA 0.04222 mg/L 3compartmentss NA 50% Rat Human -DTXSID1051808 Css NA 0.3248 mg/L 3compartmentss NA 95% Rat Human -DTXSID1051808 Css NA 0.03355 mg/L PBTK NA 50% Rat Human -DTXSID1051808 Css NA 0.2041 mg/L PBTK NA 95% Rat Human -DTXSID1051850 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051850 Fup NA 0.6662 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051850 Vd NA 0.6028 L/kg 1compartment NA NA Human Human -DTXSID1051850 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1051850 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID1051850 Css NA 1.166 mg/L 3compartmentss NA 50% Human Human -DTXSID1051850 Css NA 7.057 mg/L 3compartmentss NA 95% Human Human -DTXSID1051850 Css NA 0.9168 mg/L PBTK NA 50% Human Human -DTXSID1051850 Css NA 4.455 mg/L PBTK NA 95% Human Human -DTXSID1051850 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051850 Fup NA 0.6662 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051850 Vd NA 0.6327 L/kg 1compartment NA NA Rat Human -DTXSID1051850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1051850 TK.Half.Life NA 2.094 hours 1compartment NA NA Rat Human -DTXSID1051850 Css NA 0.3043 mg/L 3compartmentss NA 50% Rat Human -DTXSID1051850 Css NA 1.878 mg/L 3compartmentss NA 95% Rat Human -DTXSID1051850 Css NA 0.2293 mg/L PBTK NA 50% Rat Human -DTXSID1051850 Css NA 1.098 mg/L PBTK NA 95% Rat Human -DTXSID1051856 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051856 Fup NA 0.9244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051856 Vd NA 0.74 L/kg 1compartment NA NA Human Human +DTXSID1051690 TK.Half.Life NA 0.6267 hours 1compartment NA NA Rat Human +DTXSID1051690 Css NA 0.008851 mg/L 3compartmentss NA 50% Rat Human +DTXSID1051690 Css NA 0.0532 mg/L 3compartmentss NA 95% Rat Human +DTXSID1051690 Css NA 0.006551 mg/L PBTK NA 50% Rat Human +DTXSID1051690 Css NA 0.03576 mg/L PBTK NA 95% Rat Human +DTXSID1051852 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051852 Fup 0.77 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051852 Vd NA 0.6093 L/kg 1compartment NA NA Human Human +DTXSID1051852 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1051852 TK.Half.Life NA 5.119 hours 1compartment NA NA Human Human +DTXSID1051852 Css NA 0.8934 mg/L 3compartmentss NA 50% Human Human +DTXSID1051852 Css NA 5.485 mg/L 3compartmentss NA 95% Human Human +DTXSID1051852 Css NA 0.7095 mg/L PBTK NA 50% Human Human +DTXSID1051852 Css NA 3.48 mg/L PBTK NA 95% Human Human +DTXSID1051852 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051852 Fup 0.77 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051852 Vd NA 0.6495 L/kg 1compartment NA NA Rat Human +DTXSID1051852 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1051852 TK.Half.Life NA 1.86 hours 1compartment NA NA Rat Human +DTXSID1051852 Css NA 0.01694 mg/L 3compartmentss NA 50% Rat Human +DTXSID1051852 Css NA 0.1338 mg/L 3compartmentss NA 95% Rat Human +DTXSID1051852 Css NA 0.01291 mg/L PBTK NA 50% Rat Human +DTXSID1051852 Css NA 0.08408 mg/L PBTK NA 95% Rat Human +DTXSID1051856 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051856 Fup 0.893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051856 Vd NA 0.7231 L/kg 1compartment NA NA Human Human DTXSID1051856 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1051856 TK.Half.Life NA 5.18 hours 1compartment NA NA Human Human -DTXSID1051856 Css NA 0.8772 mg/L 3compartmentss NA 50% Human Human -DTXSID1051856 Css NA 3.195 mg/L 3compartmentss NA 95% Human Human -DTXSID1051856 Css NA 0.7292 mg/L PBTK NA 50% Human Human -DTXSID1051856 Css NA 2.25 mg/L PBTK NA 95% Human Human -DTXSID1051856 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051856 Fup NA 0.9244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051856 Vd NA 0.7761 L/kg 1compartment NA NA Rat Human +DTXSID1051856 TK.Half.Life NA 5.239 hours 1compartment NA NA Human Human +DTXSID1051856 Css NA 0.7958 mg/L 3compartmentss NA 50% Human Human +DTXSID1051856 Css NA 4.425 mg/L 3compartmentss NA 95% Human Human +DTXSID1051856 Css NA 0.6539 mg/L PBTK NA 50% Human Human +DTXSID1051856 Css NA 2.888 mg/L PBTK NA 95% Human Human +DTXSID1051856 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051856 Fup 0.893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051856 Vd NA 0.7586 L/kg 1compartment NA NA Rat Human DTXSID1051856 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1051856 TK.Half.Life NA 1.851 hours 1compartment NA NA Rat Human -DTXSID1051856 Css NA 0.2251 mg/L 3compartmentss NA 50% Rat Human -DTXSID1051856 Css NA 0.8014 mg/L 3compartmentss NA 95% Rat Human -DTXSID1051856 Css NA 0.1825 mg/L PBTK NA 50% Rat Human -DTXSID1051856 Css NA 0.5103 mg/L PBTK NA 95% Rat Human -DTXSID1051939 Clint NA 9.884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051939 Fup NA 0.1459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1051939 Vd NA 1.457 L/kg 1compartment NA NA Human Human +DTXSID1051856 TK.Half.Life NA 1.873 hours 1compartment NA NA Rat Human +DTXSID1051856 Css NA 0.01491 mg/L 3compartmentss NA 50% Rat Human +DTXSID1051856 Css NA 0.1109 mg/L 3compartmentss NA 95% Rat Human +DTXSID1051856 Css NA 0.01177 mg/L PBTK NA 50% Rat Human +DTXSID1051856 Css NA 0.07144 mg/L PBTK NA 95% Rat Human +DTXSID1051933 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051933 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051933 Vd NA 0.3178 L/kg 1compartment NA NA Human Human +DTXSID1051933 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1051933 TK.Half.Life NA 0.5672 hours 1compartment NA NA Human Human +DTXSID1051933 Css NA 0.1291 mg/L 3compartmentss NA 50% Human Human +DTXSID1051933 Css NA 0.9699 mg/L 3compartmentss NA 95% Human Human +DTXSID1051933 Css NA 0.08257 mg/L PBTK NA 50% Human Human +DTXSID1051933 Css NA 0.5942 mg/L PBTK NA 95% Human Human +DTXSID1051933 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051933 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051933 Vd NA 0.328 L/kg 1compartment NA NA Rat Human +DTXSID1051933 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1051933 TK.Half.Life NA 0.3265 hours 1compartment NA NA Rat Human +DTXSID1051933 Css NA 0.0165 mg/L 3compartmentss NA 50% Rat Human +DTXSID1051933 Css NA 0.08975 mg/L 3compartmentss NA 95% Rat Human +DTXSID1051933 Css NA 0.01033 mg/L PBTK NA 50% Rat Human +DTXSID1051933 Css NA 0.05333 mg/L PBTK NA 95% Rat Human +DTXSID1051939 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051939 Fup 0.0678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051939 Vd NA 1.29 L/kg 1compartment NA NA Human Human DTXSID1051939 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1051939 TK.Half.Life NA 5.428 hours 1compartment NA NA Human Human -DTXSID1051939 Css NA 0.437 mg/L 3compartmentss NA 50% Human Human -DTXSID1051939 Css NA 3.133 mg/L 3compartmentss NA 95% Human Human -DTXSID1051939 Css NA 0.2978 mg/L PBTK NA 50% Human Human -DTXSID1051939 Css NA 1.995 mg/L PBTK NA 95% Human Human -DTXSID1051939 Clint NA 9.884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051939 Fup NA 0.1459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1051939 Vd NA 1.134 L/kg 1compartment NA NA Rat Human +DTXSID1051939 TK.Half.Life NA 4.652 hours 1compartment NA NA Human Human +DTXSID1051939 Css NA 0.4536 mg/L 3compartmentss NA 50% Human Human +DTXSID1051939 Css NA 3.549 mg/L 3compartmentss NA 95% Human Human +DTXSID1051939 Css NA 0.2917 mg/L PBTK NA 50% Human Human +DTXSID1051939 Css NA 2.19 mg/L PBTK NA 95% Human Human +DTXSID1051939 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051939 Fup 0.0678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051939 Vd NA 0.9824 L/kg 1compartment NA NA Rat Human DTXSID1051939 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1051939 TK.Half.Life NA 2.163 hours 1compartment NA NA Rat Human -DTXSID1051939 Css NA 0.2307 mg/L 3compartmentss NA 50% Rat Human -DTXSID1051939 Css NA 1.197 mg/L 3compartmentss NA 95% Rat Human -DTXSID1051939 Css NA 0.1497 mg/L PBTK NA 50% Rat Human -DTXSID1051939 Css NA 0.7135 mg/L PBTK NA 95% Rat Human -DTXSID1052294 Clint NA 140.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1052294 Fup NA 0.2211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1052294 Vd NA 1.595 L/kg 1compartment NA NA Human Human +DTXSID1051939 TK.Half.Life NA 1.9 hours 1compartment NA NA Rat Human +DTXSID1051939 Css NA 0.05918 mg/L 3compartmentss NA 50% Rat Human +DTXSID1051939 Css NA 0.3443 mg/L 3compartmentss NA 95% Rat Human +DTXSID1051939 Css NA 0.03674 mg/L PBTK NA 50% Rat Human +DTXSID1051939 Css NA 0.2065 mg/L PBTK NA 95% Rat Human +DTXSID1051981 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051981 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1051981 Vd NA 2.646 L/kg 1compartment NA NA Human Human +DTXSID1051981 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1051981 TK.Half.Life NA 7.892 hours 1compartment NA NA Human Human +DTXSID1051981 Css NA 0.2586 mg/L 3compartmentss NA 50% Human Human +DTXSID1051981 Css NA 1.746 mg/L 3compartmentss NA 95% Human Human +DTXSID1051981 Css NA 0.1883 mg/L PBTK NA 50% Human Human +DTXSID1051981 Css NA 1.197 mg/L PBTK NA 95% Human Human +DTXSID1051981 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051981 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1051981 Vd NA 2.011 L/kg 1compartment NA NA Rat Human +DTXSID1051981 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1051981 TK.Half.Life NA 2.007 hours 1compartment NA NA Rat Human +DTXSID1051981 Css NA 0.03316 mg/L 3compartmentss NA 50% Rat Human +DTXSID1051981 Css NA 0.1629 mg/L 3compartmentss NA 95% Rat Human +DTXSID1051981 Css NA 0.02386 mg/L PBTK NA 50% Rat Human +DTXSID1051981 Css NA 0.1138 mg/L PBTK NA 95% Rat Human +DTXSID1052119 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052119 Fup 0.0415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052119 Vd NA 2.629 L/kg 1compartment NA NA Human Human +DTXSID1052119 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1052119 TK.Half.Life NA 23.41 hours 1compartment NA NA Human Human +DTXSID1052119 Css NA 1.158 mg/L 3compartmentss NA 50% Human Human +DTXSID1052119 Css NA 8.024 mg/L 3compartmentss NA 95% Human Human +DTXSID1052119 Css NA 0.7796 mg/L PBTK NA 50% Human Human +DTXSID1052119 Css NA 5.163 mg/L PBTK NA 95% Human Human +DTXSID1052119 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052119 Fup 0.0415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052119 Vd NA 1.968 L/kg 1compartment NA NA Rat Human +DTXSID1052119 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1052119 TK.Half.Life NA 5.394 hours 1compartment NA NA Rat Human +DTXSID1052119 Css NA 0.1481 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052119 Css NA 0.8621 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052119 Css NA 0.0983 mg/L PBTK NA 50% Rat Human +DTXSID1052119 Css NA 0.5504 mg/L PBTK NA 95% Rat Human +DTXSID1052290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052290 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052290 Vd NA 1.685 L/kg 1compartment NA NA Human Human +DTXSID1052290 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1052290 TK.Half.Life NA 7.792 hours 1compartment NA NA Human Human +DTXSID1052290 Css NA 0.6036 mg/L 3compartmentss NA 50% Human Human +DTXSID1052290 Css NA 4.386 mg/L 3compartmentss NA 95% Human Human +DTXSID1052290 Css NA 0.389 mg/L PBTK NA 50% Human Human +DTXSID1052290 Css NA 2.716 mg/L PBTK NA 95% Human Human +DTXSID1052290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052290 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052290 Vd NA 1.265 L/kg 1compartment NA NA Rat Human +DTXSID1052290 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1052290 TK.Half.Life NA 2.837 hours 1compartment NA NA Rat Human +DTXSID1052290 Css NA 0.07877 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052290 Css NA 0.4608 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052290 Css NA 0.04988 mg/L PBTK NA 50% Rat Human +DTXSID1052290 Css NA 0.2808 mg/L PBTK NA 95% Rat Human +DTXSID1052294 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052294 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052294 Vd NA 1.627 L/kg 1compartment NA NA Human Human DTXSID1052294 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1052294 TK.Half.Life NA 1.451 hours 1compartment NA NA Human Human -DTXSID1052294 Css NA 0.0191 mg/L 3compartmentss NA 50% Human Human -DTXSID1052294 Css NA 0.1359 mg/L 3compartmentss NA 95% Human Human -DTXSID1052294 Css NA 0.0138 mg/L PBTK NA 50% Human Human -DTXSID1052294 Css NA 0.09297 mg/L PBTK NA 95% Human Human -DTXSID1052294 Clint NA 140.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1052294 Fup NA 0.2211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1052294 Vd NA 1.257 L/kg 1compartment NA NA Rat Human +DTXSID1052294 TK.Half.Life NA 2.478 hours 1compartment NA NA Human Human +DTXSID1052294 Css NA 0.09366 mg/L 3compartmentss NA 50% Human Human +DTXSID1052294 Css NA 0.6405 mg/L 3compartmentss NA 95% Human Human +DTXSID1052294 Css NA 0.0697 mg/L PBTK NA 50% Human Human +DTXSID1052294 Css NA 0.4468 mg/L PBTK NA 95% Human Human +DTXSID1052294 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052294 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052294 Vd NA 1.294 L/kg 1compartment NA NA Rat Human DTXSID1052294 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1052294 TK.Half.Life NA 0.5157 hours 1compartment NA NA Rat Human -DTXSID1052294 Css NA 0.01043 mg/L 3compartmentss NA 50% Rat Human -DTXSID1052294 Css NA 0.05962 mg/L 3compartmentss NA 95% Rat Human -DTXSID1052294 Css NA 0.007328 mg/L PBTK NA 50% Rat Human -DTXSID1052294 Css NA 0.03926 mg/L PBTK NA 95% Rat Human +DTXSID1052294 TK.Half.Life NA 0.9493 hours 1compartment NA NA Rat Human +DTXSID1052294 Css NA 0.0116 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052294 Css NA 0.06259 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052294 Css NA 0.008648 mg/L PBTK NA 50% Rat Human +DTXSID1052294 Css NA 0.0438 mg/L PBTK NA 95% Rat Human DTXSID1052298 Clint NA 2.658 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1052298 Fup NA 0.5577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1052298 Vd NA 1.118 L/kg 1compartment NA NA Human Human DTXSID1052298 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID1052298 TK.Half.Life NA 2.997 hours 1compartment NA NA Human Human -DTXSID1052298 Css NA 0.2499 mg/L 3compartmentss NA 50% Human Human -DTXSID1052298 Css NA 1.978 mg/L 3compartmentss NA 95% Human Human -DTXSID1052298 Css NA 0.209 mg/L PBTK NA 50% Human Human -DTXSID1052298 Css NA 1.311 mg/L PBTK NA 95% Human Human +DTXSID1052298 Css NA 0.2406 mg/L 3compartmentss NA 50% Human Human +DTXSID1052298 Css NA 1.909 mg/L 3compartmentss NA 95% Human Human +DTXSID1052298 Css NA 0.2003 mg/L PBTK NA 50% Human Human +DTXSID1052298 Css NA 1.272 mg/L PBTK NA 95% Human Human DTXSID1052298 Clint NA 2.658 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1052298 Fup NA 0.5577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1052298 Vd NA 1.01 L/kg 1compartment NA NA Rat Human DTXSID1052298 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID1052298 TK.Half.Life NA 1.404 hours 1compartment NA NA Rat Human -DTXSID1052298 Css NA 0.1125 mg/L 3compartmentss NA 50% Rat Human -DTXSID1052298 Css NA 0.7877 mg/L 3compartmentss NA 95% Rat Human -DTXSID1052298 Css NA 0.0914 mg/L PBTK NA 50% Rat Human -DTXSID1052298 Css NA 0.4703 mg/L PBTK NA 95% Rat Human -DTXSID1057610 Clint NA 13.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057610 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057610 Vd NA 2.026 L/kg 1compartment NA NA Human Human -DTXSID1057610 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1057610 TK.Half.Life NA 31.28 hours 1compartment NA NA Human Human -DTXSID1057610 Css NA 2.416 mg/L 3compartmentss NA 50% Human Human -DTXSID1057610 Css NA 18.7 mg/L 3compartmentss NA 95% Human Human -DTXSID1057610 Css NA 1.559 mg/L PBTK NA 50% Human Human -DTXSID1057610 Css NA 11.73 mg/L PBTK NA 95% Human Human -DTXSID1057610 Clint NA 13.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057610 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057610 Vd NA 1.506 L/kg 1compartment NA NA Rat Human +DTXSID1052298 Css NA 0.02552 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052298 Css NA 0.1806 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052298 Css NA 0.02132 mg/L PBTK NA 50% Rat Human +DTXSID1052298 Css NA 0.1128 mg/L PBTK NA 95% Rat Human +DTXSID1052329 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052329 Fup 0.0086 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052329 Vd NA 0.2195 L/kg 1compartment NA NA Human Human +DTXSID1052329 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1052329 TK.Half.Life NA 4.575 hours 1compartment NA NA Human Human +DTXSID1052329 Css NA 3.282 mg/L 3compartmentss NA 50% Human Human +DTXSID1052329 Css NA 32.59 mg/L 3compartmentss NA 95% Human Human +DTXSID1052329 Css NA 1.938 mg/L PBTK NA 50% Human Human +DTXSID1052329 Css NA 18.81 mg/L PBTK NA 95% Human Human +DTXSID1052329 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052329 Fup 0.0086 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052329 Vd NA 0.2083 L/kg 1compartment NA NA Rat Human +DTXSID1052329 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1052329 TK.Half.Life NA 2.912 hours 1compartment NA NA Rat Human +DTXSID1052329 Css NA 0.1651 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052329 Css NA 1.784 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052329 Css NA 0.09315 mg/L PBTK NA 50% Rat Human +DTXSID1052329 Css NA 0.9987 mg/L PBTK NA 95% Rat Human +DTXSID1052581 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052581 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052581 Vd NA 2.008 L/kg 1compartment NA NA Human Human +DTXSID1052581 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1052581 TK.Half.Life NA 5.484 hours 1compartment NA NA Human Human +DTXSID1052581 Css NA 0.2675 mg/L 3compartmentss NA 50% Human Human +DTXSID1052581 Css NA 1.869 mg/L 3compartmentss NA 95% Human Human +DTXSID1052581 Css NA 0.1853 mg/L PBTK NA 50% Human Human +DTXSID1052581 Css NA 1.229 mg/L PBTK NA 95% Human Human +DTXSID1052581 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052581 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052581 Vd NA 1.53 L/kg 1compartment NA NA Rat Human +DTXSID1052581 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1052581 TK.Half.Life NA 1.833 hours 1compartment NA NA Rat Human +DTXSID1052581 Css NA 0.03482 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052581 Css NA 0.1891 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052581 Css NA 0.02366 mg/L PBTK NA 50% Rat Human +DTXSID1052581 Css NA 0.1223 mg/L PBTK NA 95% Rat Human +DTXSID1052585 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052585 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052585 Vd NA 2.961 L/kg 1compartment NA NA Human Human +DTXSID1052585 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1052585 TK.Half.Life NA 25.11 hours 1compartment NA NA Human Human +DTXSID1052585 Css NA 0.9688 mg/L 3compartmentss NA 50% Human Human +DTXSID1052585 Css NA 6.217 mg/L 3compartmentss NA 95% Human Human +DTXSID1052585 Css NA 0.6726 mg/L PBTK NA 50% Human Human +DTXSID1052585 Css NA 4.183 mg/L PBTK NA 95% Human Human +DTXSID1052585 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052585 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052585 Vd NA 2.224 L/kg 1compartment NA NA Rat Human +DTXSID1052585 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID1052585 TK.Half.Life NA 4.458 hours 1compartment NA NA Rat Human +DTXSID1052585 Css NA 0.1238 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052585 Css NA 0.6675 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052585 Css NA 0.08534 mg/L PBTK NA 50% Rat Human +DTXSID1052585 Css NA 0.4561 mg/L PBTK NA 95% Rat Human +DTXSID1052589 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052589 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052589 Vd NA 0.42 L/kg 1compartment NA NA Human Human +DTXSID1052589 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1052589 TK.Half.Life NA 1.095 hours 1compartment NA NA Human Human +DTXSID1052589 Css NA 0.2376 mg/L 3compartmentss NA 50% Human Human +DTXSID1052589 Css NA 1.45 mg/L 3compartmentss NA 95% Human Human +DTXSID1052589 Css NA 0.1628 mg/L PBTK NA 50% Human Human +DTXSID1052589 Css NA 0.9072 mg/L PBTK NA 95% Human Human +DTXSID1052589 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052589 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052589 Vd NA 0.4089 L/kg 1compartment NA NA Rat Human +DTXSID1052589 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1052589 TK.Half.Life NA 0.607 hours 1compartment NA NA Rat Human +DTXSID1052589 Css NA 0.02818 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052589 Css NA 0.1264 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052589 Css NA 0.01888 mg/L PBTK NA 50% Rat Human +DTXSID1052589 Css NA 0.07708 mg/L PBTK NA 95% Rat Human +DTXSID1052660 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052660 Fup 0.0998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052660 Vd NA 2.52 L/kg 1compartment NA NA Human Human +DTXSID1052660 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1052660 TK.Half.Life NA 11.34 hours 1compartment NA NA Human Human +DTXSID1052660 Css NA 0.5012 mg/L 3compartmentss NA 50% Human Human +DTXSID1052660 Css NA 3.417 mg/L 3compartmentss NA 95% Human Human +DTXSID1052660 Css NA 0.3454 mg/L PBTK NA 50% Human Human +DTXSID1052660 Css NA 2.244 mg/L PBTK NA 95% Human Human +DTXSID1052660 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052660 Fup 0.0998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052660 Vd NA 1.898 L/kg 1compartment NA NA Rat Human +DTXSID1052660 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1052660 TK.Half.Life NA 2.938 hours 1compartment NA NA Rat Human +DTXSID1052660 Css NA 0.06369 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052660 Css NA 0.3525 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052660 Css NA 0.04326 mg/L PBTK NA 50% Rat Human +DTXSID1052660 Css NA 0.2292 mg/L PBTK NA 95% Rat Human +DTXSID1052668 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052668 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052668 Vd NA 1.103 L/kg 1compartment NA NA Human Human +DTXSID1052668 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1052668 TK.Half.Life NA 2.679 hours 1compartment NA NA Human Human +DTXSID1052668 Css NA 0.2474 mg/L 3compartmentss NA 50% Human Human +DTXSID1052668 Css NA 1.983 mg/L 3compartmentss NA 95% Human Human +DTXSID1052668 Css NA 0.1622 mg/L PBTK NA 50% Human Human +DTXSID1052668 Css NA 1.238 mg/L PBTK NA 95% Human Human +DTXSID1052668 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052668 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052668 Vd NA 0.8671 L/kg 1compartment NA NA Rat Human +DTXSID1052668 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1052668 TK.Half.Life NA 1.145 hours 1compartment NA NA Rat Human +DTXSID1052668 Css NA 0.03194 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052668 Css NA 0.1992 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052668 Css NA 0.0204 mg/L PBTK NA 50% Rat Human +DTXSID1052668 Css NA 0.1198 mg/L PBTK NA 95% Rat Human +DTXSID1052741 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052741 Fup 0.455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1052741 Vd NA 1.024 L/kg 1compartment NA NA Human Human +DTXSID1052741 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1052741 TK.Half.Life NA 15.52 hours 1compartment NA NA Human Human +DTXSID1052741 Css NA 1.524 mg/L 3compartmentss NA 50% Human Human +DTXSID1052741 Css NA 7.267 mg/L 3compartmentss NA 95% Human Human +DTXSID1052741 Css NA 1.225 mg/L PBTK NA 50% Human Human +DTXSID1052741 Css NA 4.729 mg/L PBTK NA 95% Human Human +DTXSID1052741 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052741 Fup 0.455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1052741 Vd NA 0.9188 L/kg 1compartment NA NA Rat Human +DTXSID1052741 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1052741 TK.Half.Life NA 4.524 hours 1compartment NA NA Rat Human +DTXSID1052741 Css NA 0.09848 mg/L 3compartmentss NA 50% Rat Human +DTXSID1052741 Css NA 0.3873 mg/L 3compartmentss NA 95% Rat Human +DTXSID1052741 Css NA 0.07842 mg/L PBTK NA 50% Rat Human +DTXSID1052741 Css NA 0.2459 mg/L PBTK NA 95% Rat Human +DTXSID1057610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057610 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057610 Vd NA 2.425 L/kg 1compartment NA NA Human Human +DTXSID1057610 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1057610 TK.Half.Life NA 33.78 hours 1compartment NA NA Human Human +DTXSID1057610 Css NA 1.967 mg/L 3compartmentss NA 50% Human Human +DTXSID1057610 Css NA 14.79 mg/L 3compartmentss NA 95% Human Human +DTXSID1057610 Css NA 1.297 mg/L PBTK NA 50% Human Human +DTXSID1057610 Css NA 9.23 mg/L PBTK NA 95% Human Human +DTXSID1057610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057610 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057610 Vd NA 1.807 L/kg 1compartment NA NA Rat Human DTXSID1057610 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1057610 TK.Half.Life NA 9.857 hours 1compartment NA NA Rat Human -DTXSID1057610 Css NA 1.327 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057610 Css NA 8.028 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057610 Css NA 0.8052 mg/L PBTK NA 50% Rat Human -DTXSID1057610 Css NA 4.676 mg/L PBTK NA 95% Rat Human -DTXSID1057612 Clint NA 1.115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057612 Fup NA 0.9785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057612 Vd NA 4.346 L/kg 1compartment NA NA Human Human -DTXSID1057612 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID1057612 TK.Half.Life NA 57.1 hours 1compartment NA NA Human Human -DTXSID1057612 Css NA 1.063 mg/L 3compartmentss NA 50% Human Human -DTXSID1057612 Css NA 4.172 mg/L 3compartmentss NA 95% Human Human -DTXSID1057612 Css NA 1.088 mg/L PBTK NA 50% Human Human -DTXSID1057612 Css NA 3.609 mg/L PBTK NA 95% Human Human -DTXSID1057612 Clint NA 1.115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057612 Fup NA 0.9785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057612 Vd NA 3.783 L/kg 1compartment NA NA Rat Human -DTXSID1057612 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID1057612 TK.Half.Life NA 9.409 hours 1compartment NA NA Rat Human -DTXSID1057612 Css NA 0.4433 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057612 Css NA 1.297 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057612 Css NA 0.4518 mg/L PBTK NA 50% Rat Human -DTXSID1057612 Css NA 1.046 mg/L PBTK NA 95% Rat Human -DTXSID1057614 Clint NA 65.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057614 Fup NA 0.5698 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057614 Vd NA 2.945 L/kg 1compartment NA NA Human Human -DTXSID1057614 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057614 TK.Half.Life NA 1.633 hours 1compartment NA NA Human Human -DTXSID1057614 Css NA 0.009234 mg/L 3compartmentss NA 50% Human Human -DTXSID1057614 Css NA 0.1183 mg/L 3compartmentss NA 95% Human Human -DTXSID1057614 Css NA 0.01016 mg/L PBTK NA 50% Human Human -DTXSID1057614 Css NA 0.09823 mg/L PBTK NA 95% Human Human -DTXSID1057614 Clint NA 65.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057614 Fup NA 0.5698 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057614 Vd NA 3.017 L/kg 1compartment NA NA Rat Human +DTXSID1057610 TK.Half.Life NA 8.717 hours 1compartment NA NA Rat Human +DTXSID1057610 Css NA 0.2549 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057610 Css NA 1.625 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057610 Css NA 0.1646 mg/L PBTK NA 50% Rat Human +DTXSID1057610 Css NA 1.011 mg/L PBTK NA 95% Rat Human +DTXSID1057612 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057612 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057612 Vd NA 1.062 L/kg 1compartment NA NA Human Human +DTXSID1057612 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1057612 TK.Half.Life NA 2.021 hours 1compartment NA NA Human Human +DTXSID1057612 Css NA 0.1575 mg/L 3compartmentss NA 50% Human Human +DTXSID1057612 Css NA 1.328 mg/L 3compartmentss NA 95% Human Human +DTXSID1057612 Css NA 0.1106 mg/L PBTK NA 50% Human Human +DTXSID1057612 Css NA 0.846 mg/L PBTK NA 95% Human Human +DTXSID1057612 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057612 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057612 Vd NA 1.044 L/kg 1compartment NA NA Rat Human +DTXSID1057612 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1057612 TK.Half.Life NA 1.144 hours 1compartment NA NA Rat Human +DTXSID1057612 Css NA 0.02038 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057612 Css NA 0.1315 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057612 Css NA 0.01414 mg/L PBTK NA 50% Rat Human +DTXSID1057612 Css NA 0.08333 mg/L PBTK NA 95% Rat Human +DTXSID1057614 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057614 Fup 0.54 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057614 Vd NA 1.431 L/kg 1compartment NA NA Human Human +DTXSID1057614 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1057614 TK.Half.Life NA 17.17 hours 1compartment NA NA Human Human +DTXSID1057614 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human +DTXSID1057614 Css NA 6.699 mg/L 3compartmentss NA 95% Human Human +DTXSID1057614 Css NA 0.9172 mg/L PBTK NA 50% Human Human +DTXSID1057614 Css NA 4.453 mg/L PBTK NA 95% Human Human +DTXSID1057614 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057614 Fup 0.54 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057614 Vd NA 1.446 L/kg 1compartment NA NA Rat Human DTXSID1057614 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057614 TK.Half.Life NA 0.7954 hours 1compartment NA NA Rat Human -DTXSID1057614 Css NA 0.004729 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057614 Css NA 0.05654 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057614 Css NA 0.005252 mg/L PBTK NA 50% Rat Human -DTXSID1057614 Css NA 0.04229 mg/L PBTK NA 95% Rat Human -DTXSID1057616 Clint NA 1.884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057616 Fup NA 0.7929 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057616 Vd NA 1.137 L/kg 1compartment NA NA Human Human +DTXSID1057614 TK.Half.Life NA 5.904 hours 1compartment NA NA Rat Human +DTXSID1057614 Css NA 0.02538 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057614 Css NA 0.2116 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057614 Css NA 0.02266 mg/L PBTK NA 50% Rat Human +DTXSID1057614 Css NA 0.1398 mg/L PBTK NA 95% Rat Human +DTXSID1057616 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057616 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057616 Vd NA 0.9587 L/kg 1compartment NA NA Human Human DTXSID1057616 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057616 TK.Half.Life NA 2.718 hours 1compartment NA NA Human Human -DTXSID1057616 Css NA 0.2409 mg/L 3compartmentss NA 50% Human Human -DTXSID1057616 Css NA 1.715 mg/L 3compartmentss NA 95% Human Human -DTXSID1057616 Css NA 0.2099 mg/L PBTK NA 50% Human Human -DTXSID1057616 Css NA 1.155 mg/L PBTK NA 95% Human Human -DTXSID1057616 Clint NA 1.884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057616 Fup NA 0.7929 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057616 Vd NA 1.065 L/kg 1compartment NA NA Rat Human +DTXSID1057616 TK.Half.Life NA 9.319 hours 1compartment NA NA Human Human +DTXSID1057616 Css NA 1.046 mg/L 3compartmentss NA 50% Human Human +DTXSID1057616 Css NA 6.972 mg/L 3compartmentss NA 95% Human Human +DTXSID1057616 Css NA 0.884 mg/L PBTK NA 50% Human Human +DTXSID1057616 Css NA 4.512 mg/L PBTK NA 95% Human Human +DTXSID1057616 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057616 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057616 Vd NA 0.9129 L/kg 1compartment NA NA Rat Human DTXSID1057616 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057616 TK.Half.Life NA 1.279 hours 1compartment NA NA Rat Human -DTXSID1057616 Css NA 0.09992 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057616 Css NA 0.6592 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057616 Css NA 0.08568 mg/L PBTK NA 50% Rat Human -DTXSID1057616 Css NA 0.4074 mg/L PBTK NA 95% Rat Human -DTXSID1057618 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057618 Fup NA 0.2741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057618 Vd NA 0.4321 L/kg 1compartment NA NA Human Human -DTXSID1057618 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1057618 TK.Half.Life NA 10.2 hours 1compartment NA NA Human Human -DTXSID1057618 Css NA 2.764 mg/L 3compartmentss NA 50% Human Human -DTXSID1057618 Css NA 10.89 mg/L 3compartmentss NA 95% Human Human -DTXSID1057618 Css NA 1.922 mg/L PBTK NA 50% Human Human -DTXSID1057618 Css NA 6.7 mg/L PBTK NA 95% Human Human -DTXSID1057618 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057618 Fup NA 0.2741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057618 Vd NA 0.4365 L/kg 1compartment NA NA Rat Human +DTXSID1057616 TK.Half.Life NA 2.956 hours 1compartment NA NA Rat Human +DTXSID1057616 Css NA 0.06305 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057616 Css NA 0.4078 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057616 Css NA 0.0534 mg/L PBTK NA 50% Rat Human +DTXSID1057616 Css NA 0.2519 mg/L PBTK NA 95% Rat Human +DTXSID1057618 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057618 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057618 Vd NA 0.544 L/kg 1compartment NA NA Human Human +DTXSID1057618 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1057618 TK.Half.Life NA 0.6424 hours 1compartment NA NA Human Human +DTXSID1057618 Css NA 0.05419 mg/L 3compartmentss NA 50% Human Human +DTXSID1057618 Css NA 0.4243 mg/L 3compartmentss NA 95% Human Human +DTXSID1057618 Css NA 0.03996 mg/L PBTK NA 50% Human Human +DTXSID1057618 Css NA 0.2854 mg/L PBTK NA 95% Human Human +DTXSID1057618 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057618 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057618 Vd NA 0.5517 L/kg 1compartment NA NA Rat Human DTXSID1057618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057618 TK.Half.Life NA 3.511 hours 1compartment NA NA Rat Human -DTXSID1057618 Css NA 0.7722 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057618 Css NA 2.554 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057618 Css NA 0.509 mg/L PBTK NA 50% Rat Human -DTXSID1057618 Css NA 1.484 mg/L PBTK NA 95% Rat Human -DTXSID1057660 Clint NA 10.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057660 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057660 Vd NA 0.5627 L/kg 1compartment NA NA Human Human +DTXSID1057618 TK.Half.Life NA 0.3403 hours 1compartment NA NA Rat Human +DTXSID1057618 Css NA 0.006721 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057618 Css NA 0.03991 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057618 Css NA 0.004915 mg/L PBTK NA 50% Rat Human +DTXSID1057618 Css NA 0.0264 mg/L PBTK NA 95% Rat Human +DTXSID1057660 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057660 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057660 Vd NA 0.6129 L/kg 1compartment NA NA Human Human DTXSID1057660 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057660 TK.Half.Life NA 3.755 hours 1compartment NA NA Human Human -DTXSID1057660 Css NA 1.03 mg/L 3compartmentss NA 50% Human Human -DTXSID1057660 Css NA 7.574 mg/L 3compartmentss NA 95% Human Human -DTXSID1057660 Css NA 0.6296 mg/L PBTK NA 50% Human Human -DTXSID1057660 Css NA 4.568 mg/L PBTK NA 95% Human Human -DTXSID1057660 Clint NA 10.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057660 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057660 Vd NA 0.4587 L/kg 1compartment NA NA Rat Human +DTXSID1057660 TK.Half.Life NA 2.4 hours 1compartment NA NA Human Human +DTXSID1057660 Css NA 0.4128 mg/L 3compartmentss NA 50% Human Human +DTXSID1057660 Css NA 2.577 mg/L 3compartmentss NA 95% Human Human +DTXSID1057660 Css NA 0.2754 mg/L PBTK NA 50% Human Human +DTXSID1057660 Css NA 1.62 mg/L PBTK NA 95% Human Human +DTXSID1057660 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057660 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057660 Vd NA 0.5444 L/kg 1compartment NA NA Rat Human DTXSID1057660 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057660 TK.Half.Life NA 1.885 hours 1compartment NA NA Rat Human -DTXSID1057660 Css NA 0.5732 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057660 Css NA 3.158 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057660 Css NA 0.3282 mg/L PBTK NA 50% Rat Human -DTXSID1057660 Css NA 1.756 mg/L PBTK NA 95% Rat Human -DTXSID1057662 Clint NA 182.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057662 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057662 Vd NA 1.16 L/kg 1compartment NA NA Human Human +DTXSID1057660 TK.Half.Life NA 1.245 hours 1compartment NA NA Rat Human +DTXSID1057660 Css NA 0.04974 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057660 Css NA 0.2184 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057660 Css NA 0.03266 mg/L PBTK NA 50% Rat Human +DTXSID1057660 Css NA 0.1342 mg/L PBTK NA 95% Rat Human +DTXSID1057662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057662 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057662 Vd NA 2.848 L/kg 1compartment NA NA Human Human DTXSID1057662 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057662 TK.Half.Life NA 1.284 hours 1compartment NA NA Human Human -DTXSID1057662 Css NA 0.0412 mg/L 3compartmentss NA 50% Human Human -DTXSID1057662 Css NA 0.458 mg/L 3compartmentss NA 95% Human Human -DTXSID1057662 Css NA 0.0266 mg/L PBTK NA 50% Human Human -DTXSID1057662 Css NA 0.2757 mg/L PBTK NA 95% Human Human -DTXSID1057662 Clint NA 182.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057662 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057662 Vd NA 1.011 L/kg 1compartment NA NA Rat Human +DTXSID1057662 TK.Half.Life NA 3.27 hours 1compartment NA NA Human Human +DTXSID1057662 Css NA 0.06515 mg/L 3compartmentss NA 50% Human Human +DTXSID1057662 Css NA 0.5874 mg/L 3compartmentss NA 95% Human Human +DTXSID1057662 Css NA 0.05346 mg/L PBTK NA 50% Human Human +DTXSID1057662 Css NA 0.421 mg/L PBTK NA 95% Human Human +DTXSID1057662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057662 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057662 Vd NA 2.566 L/kg 1compartment NA NA Rat Human DTXSID1057662 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057662 TK.Half.Life NA 0.5428 hours 1compartment NA NA Rat Human -DTXSID1057662 Css NA 0.0239 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057662 Css NA 0.222 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057662 Css NA 0.01438 mg/L PBTK NA 50% Rat Human -DTXSID1057662 Css NA 0.1259 mg/L PBTK NA 95% Rat Human -DTXSID1057664 Clint NA 1.671 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057664 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057664 Vd NA 0.1778 L/kg 1compartment NA NA Human Human -DTXSID1057664 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1057664 TK.Half.Life NA 15.59 hours 1compartment NA NA Human Human -DTXSID1057664 Css NA 15.98 mg/L 3compartmentss NA 50% Human Human -DTXSID1057664 Css NA 110.1 mg/L 3compartmentss NA 95% Human Human -DTXSID1057664 Css NA 9.348 mg/L PBTK NA 50% Human Human -DTXSID1057664 Css NA 63.82 mg/L PBTK NA 95% Human Human -DTXSID1057664 Clint NA 1.671 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057664 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057664 Vd NA 0.1759 L/kg 1compartment NA NA Rat Human +DTXSID1057662 TK.Half.Life NA 1.415 hours 1compartment NA NA Rat Human +DTXSID1057662 Css NA 0.008672 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057662 Css NA 0.06278 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057662 Css NA 0.007108 mg/L PBTK NA 50% Rat Human +DTXSID1057662 Css NA 0.04598 mg/L PBTK NA 95% Rat Human +DTXSID1057664 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057664 Fup 0.0732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057664 Vd NA 0.2213 L/kg 1compartment NA NA Human Human +DTXSID1057664 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1057664 TK.Half.Life NA 0.7276 hours 1compartment NA NA Human Human +DTXSID1057664 Css NA 0.412 mg/L 3compartmentss NA 50% Human Human +DTXSID1057664 Css NA 3.397 mg/L 3compartmentss NA 95% Human Human +DTXSID1057664 Css NA 0.2466 mg/L PBTK NA 50% Human Human +DTXSID1057664 Css NA 1.975 mg/L PBTK NA 95% Human Human +DTXSID1057664 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057664 Fup 0.0732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057664 Vd NA 0.2198 L/kg 1compartment NA NA Rat Human DTXSID1057664 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057664 TK.Half.Life NA 8.426 hours 1compartment NA NA Rat Human -DTXSID1057664 Css NA 7.19 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057664 Css NA 41.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057664 Css NA 3.925 mg/L PBTK NA 50% Rat Human -DTXSID1057664 Css NA 22.36 mg/L PBTK NA 95% Rat Human -DTXSID1057666 Clint NA 17.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID1057664 TK.Half.Life NA 0.4404 hours 1compartment NA NA Rat Human +DTXSID1057664 Css NA 0.05483 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057664 Css NA 0.3415 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057664 Css NA 0.03174 mg/L PBTK NA 50% Rat Human +DTXSID1057664 Css NA 0.1956 mg/L PBTK NA 95% Rat Human +DTXSID1057666 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID1057666 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID1057666 Vd NA 0.9826 L/kg 1compartment NA NA Human Human +DTXSID1057666 Vd NA 1.053 L/kg 1compartment NA NA Human Human DTXSID1057666 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057666 TK.Half.Life NA 0.7664 hours 1compartment NA NA Human Human -DTXSID1057666 Css NA 0.03357 mg/L 3compartmentss NA 50% Human Human -DTXSID1057666 Css NA 0.3193 mg/L 3compartmentss NA 95% Human Human -DTXSID1057666 Css NA 0.02854 mg/L PBTK NA 50% Human Human -DTXSID1057666 Css NA 0.2298 mg/L PBTK NA 95% Human Human -DTXSID1057666 Clint NA 17.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID1057666 TK.Half.Life NA 1.206 hours 1compartment NA NA Human Human +DTXSID1057666 Css NA 0.08191 mg/L 3compartmentss NA 50% Human Human +DTXSID1057666 Css NA 0.7118 mg/L 3compartmentss NA 95% Human Human +DTXSID1057666 Css NA 0.06958 mg/L PBTK NA 50% Human Human +DTXSID1057666 Css NA 0.4978 mg/L PBTK NA 95% Human Human +DTXSID1057666 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID1057666 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID1057666 Vd NA 0.9674 L/kg 1compartment NA NA Rat Human +DTXSID1057666 Vd NA 1.022 L/kg 1compartment NA NA Rat Human DTXSID1057666 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057666 TK.Half.Life NA 0.3701 hours 1compartment NA NA Rat Human -DTXSID1057666 Css NA 0.01642 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057666 Css NA 0.1397 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057666 Css NA 0.01393 mg/L PBTK NA 50% Rat Human -DTXSID1057666 Css NA 0.09553 mg/L PBTK NA 95% Rat Human +DTXSID1057666 TK.Half.Life NA 0.6112 hours 1compartment NA NA Rat Human +DTXSID1057666 Css NA 0.008827 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057666 Css NA 0.06688 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057666 Css NA 0.007876 mg/L PBTK NA 50% Rat Human +DTXSID1057666 Css NA 0.04522 mg/L PBTK NA 95% Rat Human DTXSID1057668 Clint NA 3.552 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1057668 Fup NA 0.1243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057668 Vd NA 0.3237 L/kg 1compartment NA NA Human Human +DTXSID1057668 Vd NA 0.3712 L/kg 1compartment NA NA Human Human DTXSID1057668 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057668 TK.Half.Life NA 2.631 hours 1compartment NA NA Human Human -DTXSID1057668 Css NA 1.195 mg/L 3compartmentss NA 50% Human Human -DTXSID1057668 Css NA 7.87 mg/L 3compartmentss NA 95% Human Human -DTXSID1057668 Css NA 0.7502 mg/L PBTK NA 50% Human Human -DTXSID1057668 Css NA 4.713 mg/L PBTK NA 95% Human Human +DTXSID1057668 TK.Half.Life NA 3.037 hours 1compartment NA NA Human Human +DTXSID1057668 Css NA 0.6192 mg/L 3compartmentss NA 50% Human Human +DTXSID1057668 Css NA 4.251 mg/L 3compartmentss NA 95% Human Human +DTXSID1057668 Css NA 0.4019 mg/L PBTK NA 50% Human Human +DTXSID1057668 Css NA 2.577 mg/L PBTK NA 95% Human Human DTXSID1057668 Clint NA 3.552 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1057668 Fup NA 0.1243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057668 Vd NA 0.3237 L/kg 1compartment NA NA Rat Human +DTXSID1057668 Vd NA 0.368 L/kg 1compartment NA NA Rat Human DTXSID1057668 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057668 TK.Half.Life NA 1.544 hours 1compartment NA NA Rat Human -DTXSID1057668 Css NA 0.605 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057668 Css NA 2.814 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057668 Css NA 0.3577 mg/L PBTK NA 50% Rat Human -DTXSID1057668 Css NA 1.565 mg/L PBTK NA 95% Rat Human -DTXSID1057741 Clint NA 7.256 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057741 Fup NA 0.1004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057741 Vd NA 1.863 L/kg 1compartment NA NA Human Human -DTXSID1057741 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1057741 TK.Half.Life NA 13.79 hours 1compartment NA NA Human Human -DTXSID1057741 Css NA 1 mg/L 3compartmentss NA 50% Human Human -DTXSID1057741 Css NA 6.389 mg/L 3compartmentss NA 95% Human Human -DTXSID1057741 Css NA 0.6742 mg/L PBTK NA 50% Human Human -DTXSID1057741 Css NA 4.07 mg/L PBTK NA 95% Human Human -DTXSID1057741 Clint NA 7.256 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057741 Fup NA 0.1004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057741 Vd NA 1.42 L/kg 1compartment NA NA Rat Human +DTXSID1057668 TK.Half.Life NA 1.768 hours 1compartment NA NA Rat Human +DTXSID1057668 Css NA 0.006045 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057668 Css NA 0.03532 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057668 Css NA 0.003657 mg/L PBTK NA 50% Rat Human +DTXSID1057668 Css NA 0.02033 mg/L PBTK NA 95% Rat Human +DTXSID1057741 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057741 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057741 Vd NA 1.601 L/kg 1compartment NA NA Human Human +DTXSID1057741 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1057741 TK.Half.Life NA 2.533 hours 1compartment NA NA Human Human +DTXSID1057741 Css NA 0.1015 mg/L 3compartmentss NA 50% Human Human +DTXSID1057741 Css NA 0.68 mg/L 3compartmentss NA 95% Human Human +DTXSID1057741 Css NA 0.07466 mg/L PBTK NA 50% Human Human +DTXSID1057741 Css NA 0.4756 mg/L PBTK NA 95% Human Human +DTXSID1057741 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057741 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057741 Vd NA 1.28 L/kg 1compartment NA NA Rat Human DTXSID1057741 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057741 TK.Half.Life NA 4.735 hours 1compartment NA NA Rat Human -DTXSID1057741 Css NA 0.5251 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057741 Css NA 2.442 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057741 Css NA 0.337 mg/L PBTK NA 50% Rat Human -DTXSID1057741 Css NA 1.461 mg/L PBTK NA 95% Rat Human -DTXSID1057743 Clint NA 8.259 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057743 Fup NA 0.1057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057743 Vd NA 2.754 L/kg 1compartment NA NA Human Human -DTXSID1057743 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID1057743 TK.Half.Life NA 34.37 hours 1compartment NA NA Human Human -DTXSID1057743 Css NA 1.569 mg/L 3compartmentss NA 50% Human Human -DTXSID1057743 Css NA 9.293 mg/L 3compartmentss NA 95% Human Human -DTXSID1057743 Css NA 1.091 mg/L PBTK NA 50% Human Human -DTXSID1057743 Css NA 6.145 mg/L PBTK NA 95% Human Human -DTXSID1057743 Clint NA 8.259 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057743 Fup NA 0.1057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057743 Vd NA 2.085 L/kg 1compartment NA NA Rat Human -DTXSID1057743 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID1057743 TK.Half.Life NA 7.244 hours 1compartment NA NA Rat Human -DTXSID1057743 Css NA 0.8438 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057743 Css NA 3.658 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057743 Css NA 0.5627 mg/L PBTK NA 50% Rat Human -DTXSID1057743 Css NA 2.364 mg/L PBTK NA 95% Rat Human -DTXSID1057745 Clint NA 38.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057745 Fup NA 0.0428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057745 Vd NA 2.727 L/kg 1compartment NA NA Human Human -DTXSID1057745 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID1057745 TK.Half.Life NA 15.98 hours 1compartment NA NA Human Human -DTXSID1057745 Css NA 0.708 mg/L 3compartmentss NA 50% Human Human -DTXSID1057745 Css NA 4.912 mg/L 3compartmentss NA 95% Human Human -DTXSID1057745 Css NA 0.482 mg/L PBTK NA 50% Human Human -DTXSID1057745 Css NA 3.18 mg/L PBTK NA 95% Human Human -DTXSID1057745 Clint NA 38.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057745 Fup NA 0.0428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057745 Vd NA 2.043 L/kg 1compartment NA NA Rat Human -DTXSID1057745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057745 TK.Half.Life NA 3.542 hours 1compartment NA NA Rat Human -DTXSID1057745 Css NA 0.4001 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057745 Css NA 2.231 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057745 Css NA 0.2588 mg/L PBTK NA 50% Rat Human -DTXSID1057745 Css NA 1.354 mg/L PBTK NA 95% Rat Human -DTXSID1057747 Clint NA 13.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057747 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057747 Vd NA 1.938 L/kg 1compartment NA NA Human Human -DTXSID1057747 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1057747 TK.Half.Life NA 20.48 hours 1compartment NA NA Human Human -DTXSID1057747 Css NA 1.614 mg/L 3compartmentss NA 50% Human Human -DTXSID1057747 Css NA 11.04 mg/L 3compartmentss NA 95% Human Human -DTXSID1057747 Css NA 1.039 mg/L PBTK NA 50% Human Human -DTXSID1057747 Css NA 6.862 mg/L PBTK NA 95% Human Human -DTXSID1057747 Clint NA 13.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057747 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057747 Vd NA 1.447 L/kg 1compartment NA NA Rat Human -DTXSID1057747 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1057747 TK.Half.Life NA 6.743 hours 1compartment NA NA Rat Human -DTXSID1057747 Css NA 0.8925 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057747 Css NA 4.466 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057747 Css NA 0.5444 mg/L PBTK NA 50% Rat Human -DTXSID1057747 Css NA 2.627 mg/L PBTK NA 95% Rat Human -DTXSID1057749 Clint NA 30.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057749 Fup NA 0.0219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057749 Vd NA 2.782 L/kg 1compartment NA NA Human Human -DTXSID1057749 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1057749 TK.Half.Life NA 28.44 hours 1compartment NA NA Human Human -DTXSID1057749 Css NA 1.343 mg/L 3compartmentss NA 50% Human Human -DTXSID1057749 Css NA 9.346 mg/L 3compartmentss NA 95% Human Human -DTXSID1057749 Css NA 0.9166 mg/L PBTK NA 50% Human Human -DTXSID1057749 Css NA 6.118 mg/L PBTK NA 95% Human Human -DTXSID1057749 Clint NA 30.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057749 Fup NA 0.0219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057749 Vd NA 2.096 L/kg 1compartment NA NA Rat Human -DTXSID1057749 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1057749 TK.Half.Life NA 6.054 hours 1compartment NA NA Rat Human -DTXSID1057749 Css NA 0.7481 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057749 Css NA 4.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057749 Css NA 0.4846 mg/L PBTK NA 50% Rat Human -DTXSID1057749 Css NA 2.75 mg/L PBTK NA 95% Rat Human -DTXSID1057791 Clint NA 0.2751 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057791 Fup NA 0.1585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057791 Vd NA 0.2785 L/kg 1compartment NA NA Human Human +DTXSID1057741 TK.Half.Life NA 0.988 hours 1compartment NA NA Rat Human +DTXSID1057741 Css NA 0.01247 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057741 Css NA 0.06521 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057741 Css NA 0.009214 mg/L PBTK NA 50% Rat Human +DTXSID1057741 Css NA 0.04508 mg/L PBTK NA 95% Rat Human +DTXSID1057743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057743 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057743 Vd NA 2.41 L/kg 1compartment NA NA Human Human +DTXSID1057743 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1057743 TK.Half.Life NA 6.822 hours 1compartment NA NA Human Human +DTXSID1057743 Css NA 0.2582 mg/L 3compartmentss NA 50% Human Human +DTXSID1057743 Css NA 1.748 mg/L 3compartmentss NA 95% Human Human +DTXSID1057743 Css NA 0.1855 mg/L PBTK NA 50% Human Human +DTXSID1057743 Css NA 1.171 mg/L PBTK NA 95% Human Human +DTXSID1057743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057743 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057743 Vd NA 1.851 L/kg 1compartment NA NA Rat Human +DTXSID1057743 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1057743 TK.Half.Life NA 2.02 hours 1compartment NA NA Rat Human +DTXSID1057743 Css NA 0.03296 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057743 Css NA 0.1723 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057743 Css NA 0.02347 mg/L PBTK NA 50% Rat Human +DTXSID1057743 Css NA 0.1164 mg/L PBTK NA 95% Rat Human +DTXSID1057745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057745 Fup 0.0107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057745 Vd NA 2.229 L/kg 1compartment NA NA Human Human +DTXSID1057745 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID1057745 TK.Half.Life NA 35.15 hours 1compartment NA NA Human Human +DTXSID1057745 Css NA 2.347 mg/L 3compartmentss NA 50% Human Human +DTXSID1057745 Css NA 17.76 mg/L 3compartmentss NA 95% Human Human +DTXSID1057745 Css NA 1.509 mg/L PBTK NA 50% Human Human +DTXSID1057745 Css NA 11.23 mg/L PBTK NA 95% Human Human +DTXSID1057745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057745 Fup 0.0107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057745 Vd NA 1.656 L/kg 1compartment NA NA Rat Human +DTXSID1057745 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID1057745 TK.Half.Life NA 10.1 hours 1compartment NA NA Rat Human +DTXSID1057745 Css NA 0.304 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057745 Css NA 2.032 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057745 Css NA 0.1928 mg/L PBTK NA 50% Rat Human +DTXSID1057745 Css NA 1.235 mg/L PBTK NA 95% Rat Human +DTXSID1057747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057747 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057747 Vd NA 1.593 L/kg 1compartment NA NA Human Human +DTXSID1057747 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1057747 TK.Half.Life NA 14.84 hours 1compartment NA NA Human Human +DTXSID1057747 Css NA 1.444 mg/L 3compartmentss NA 50% Human Human +DTXSID1057747 Css NA 12.27 mg/L 3compartmentss NA 95% Human Human +DTXSID1057747 Css NA 0.9043 mg/L PBTK NA 50% Human Human +DTXSID1057747 Css NA 7.518 mg/L PBTK NA 95% Human Human +DTXSID1057747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057747 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057747 Vd NA 1.182 L/kg 1compartment NA NA Rat Human +DTXSID1057747 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1057747 TK.Half.Life NA 5.545 hours 1compartment NA NA Rat Human +DTXSID1057747 Css NA 0.1833 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057747 Css NA 1.34 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057747 Css NA 0.1119 mg/L PBTK NA 50% Rat Human +DTXSID1057747 Css NA 0.7842 mg/L PBTK NA 95% Rat Human +DTXSID1057749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057749 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057749 Vd NA 3.355 L/kg 1compartment NA NA Human Human +DTXSID1057749 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1057749 TK.Half.Life NA 5.134 hours 1compartment NA NA Human Human +DTXSID1057749 Css NA 0.1014 mg/L 3compartmentss NA 50% Human Human +DTXSID1057749 Css NA 0.8025 mg/L 3compartmentss NA 95% Human Human +DTXSID1057749 Css NA 0.08178 mg/L PBTK NA 50% Human Human +DTXSID1057749 Css NA 0.5917 mg/L PBTK NA 95% Human Human +DTXSID1057749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057749 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057749 Vd NA 2.848 L/kg 1compartment NA NA Rat Human +DTXSID1057749 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1057749 TK.Half.Life NA 1.702 hours 1compartment NA NA Rat Human +DTXSID1057749 Css NA 0.01326 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057749 Css NA 0.08852 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057749 Css NA 0.01078 mg/L PBTK NA 50% Rat Human +DTXSID1057749 Css NA 0.06537 mg/L PBTK NA 95% Rat Human +DTXSID1057791 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057791 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057791 Vd NA 0.4156 L/kg 1compartment NA NA Human Human DTXSID1057791 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057791 TK.Half.Life NA 7.79 hours 1compartment NA NA Human Human -DTXSID1057791 Css NA 3.872 mg/L 3compartmentss NA 50% Human Human -DTXSID1057791 Css NA 16.25 mg/L 3compartmentss NA 95% Human Human -DTXSID1057791 Css NA 2.437 mg/L PBTK NA 50% Human Human -DTXSID1057791 Css NA 9.534 mg/L PBTK NA 95% Human Human -DTXSID1057791 Clint NA 0.2751 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057791 Fup NA 0.1585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057791 Vd NA 0.2805 L/kg 1compartment NA NA Rat Human +DTXSID1057791 TK.Half.Life NA 7.575 hours 1compartment NA NA Human Human +DTXSID1057791 Css NA 1.807 mg/L 3compartmentss NA 50% Human Human +DTXSID1057791 Css NA 7.478 mg/L 3compartmentss NA 95% Human Human +DTXSID1057791 Css NA 1.279 mg/L PBTK NA 50% Human Human +DTXSID1057791 Css NA 4.707 mg/L PBTK NA 95% Human Human +DTXSID1057791 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057791 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057791 Vd NA 0.4193 L/kg 1compartment NA NA Rat Human DTXSID1057791 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057791 TK.Half.Life NA 3.188 hours 1compartment NA NA Rat Human -DTXSID1057791 Css NA 1.317 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057791 Css NA 4.827 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057791 Css NA 0.7762 mg/L PBTK NA 50% Rat Human -DTXSID1057791 Css NA 2.68 mg/L PBTK NA 95% Rat Human -DTXSID1057793 Clint NA 11.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057793 Fup NA 0.208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057793 Vd NA 1.027 L/kg 1compartment NA NA Human Human +DTXSID1057791 TK.Half.Life NA 2.604 hours 1compartment NA NA Rat Human +DTXSID1057791 Css NA 0.04478 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057791 Css NA 0.2551 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057791 Css NA 0.03073 mg/L PBTK NA 50% Rat Human +DTXSID1057791 Css NA 0.1591 mg/L PBTK NA 95% Rat Human +DTXSID1057793 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057793 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057793 Vd NA 1.437 L/kg 1compartment NA NA Human Human DTXSID1057793 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057793 TK.Half.Life NA 2.463 hours 1compartment NA NA Human Human -DTXSID1057793 Css NA 0.211 mg/L 3compartmentss NA 50% Human Human -DTXSID1057793 Css NA 1.26 mg/L 3compartmentss NA 95% Human Human -DTXSID1057793 Css NA 0.1481 mg/L PBTK NA 50% Human Human -DTXSID1057793 Css NA 0.8507 mg/L PBTK NA 95% Human Human -DTXSID1057793 Clint NA 11.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057793 Fup NA 0.208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057793 Vd NA 0.8483 L/kg 1compartment NA NA Rat Human +DTXSID1057793 TK.Half.Life NA 2.261 hours 1compartment NA NA Human Human +DTXSID1057793 Css NA 0.099 mg/L 3compartmentss NA 50% Human Human +DTXSID1057793 Css NA 0.711 mg/L 3compartmentss NA 95% Human Human +DTXSID1057793 Css NA 0.07246 mg/L PBTK NA 50% Human Human +DTXSID1057793 Css NA 0.4778 mg/L PBTK NA 95% Human Human +DTXSID1057793 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057793 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057793 Vd NA 1.15 L/kg 1compartment NA NA Rat Human DTXSID1057793 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057793 TK.Half.Life NA 1.117 hours 1compartment NA NA Rat Human -DTXSID1057793 Css NA 0.11 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057793 Css NA 0.5252 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057793 Css NA 0.07446 mg/L PBTK NA 50% Rat Human -DTXSID1057793 Css NA 0.3286 mg/L PBTK NA 95% Rat Human -DTXSID1057795 Clint NA 33.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057795 Fup NA 0.7056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057795 Vd NA 0.5175 L/kg 1compartment NA NA Human Human +DTXSID1057793 TK.Half.Life NA 0.9023 hours 1compartment NA NA Rat Human +DTXSID1057793 Css NA 0.01233 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057793 Css NA 0.06525 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057793 Css NA 0.00897 mg/L PBTK NA 50% Rat Human +DTXSID1057793 Css NA 0.04476 mg/L PBTK NA 95% Rat Human +DTXSID1057795 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057795 Fup 0.631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057795 Vd NA 0.4733 L/kg 1compartment NA NA Human Human DTXSID1057795 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057795 TK.Half.Life NA 0.425 hours 1compartment NA NA Human Human -DTXSID1057795 Css NA 0.02315 mg/L 3compartmentss NA 50% Human Human -DTXSID1057795 Css NA 0.2189 mg/L 3compartmentss NA 95% Human Human -DTXSID1057795 Css NA 0.01693 mg/L PBTK NA 50% Human Human -DTXSID1057795 Css NA 0.1445 mg/L PBTK NA 95% Human Human -DTXSID1057795 Clint NA 33.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057795 Fup NA 0.7056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057795 Vd NA 0.5296 L/kg 1compartment NA NA Rat Human +DTXSID1057795 TK.Half.Life NA 4.857 hours 1compartment NA NA Human Human +DTXSID1057795 Css NA 1.239 mg/L 3compartmentss NA 50% Human Human +DTXSID1057795 Css NA 7.842 mg/L 3compartmentss NA 95% Human Human +DTXSID1057795 Css NA 0.912 mg/L PBTK NA 50% Human Human +DTXSID1057795 Css NA 4.823 mg/L PBTK NA 95% Human Human +DTXSID1057795 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057795 Fup 0.631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057795 Vd NA 0.4847 L/kg 1compartment NA NA Rat Human DTXSID1057795 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057795 TK.Half.Life NA 0.204 hours 1compartment NA NA Rat Human -DTXSID1057795 Css NA 0.0117 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057795 Css NA 0.1038 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057795 Css NA 0.00838 mg/L PBTK NA 50% Rat Human -DTXSID1057795 Css NA 0.06602 mg/L PBTK NA 95% Rat Human -DTXSID1057797 Clint NA 2.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057797 Fup NA 0.0817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057797 Vd NA 1.4 L/kg 1compartment NA NA Human Human -DTXSID1057797 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID1057797 TK.Half.Life NA 27.07 hours 1compartment NA NA Human Human -DTXSID1057797 Css NA 2.939 mg/L 3compartmentss NA 50% Human Human -DTXSID1057797 Css NA 15.48 mg/L 3compartmentss NA 95% Human Human -DTXSID1057797 Css NA 1.923 mg/L PBTK NA 50% Human Human -DTXSID1057797 Css NA 9.489 mg/L PBTK NA 95% Human Human -DTXSID1057797 Clint NA 2.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057797 Fup NA 0.0817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057797 Vd NA 1.073 L/kg 1compartment NA NA Rat Human -DTXSID1057797 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID1057797 TK.Half.Life NA 9.863 hours 1compartment NA NA Rat Human -DTXSID1057797 Css NA 1.401 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057797 Css NA 5.793 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057797 Css NA 0.8664 mg/L PBTK NA 50% Rat Human -DTXSID1057797 Css NA 3.262 mg/L PBTK NA 95% Rat Human -DTXSID1057799 Clint NA 4.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057799 Fup NA 0.1871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057799 Vd NA 1.705 L/kg 1compartment NA NA Human Human +DTXSID1057795 TK.Half.Life NA 1.694 hours 1compartment NA NA Rat Human +DTXSID1057795 Css NA 0.07624 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057795 Css NA 0.428 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057795 Css NA 0.05542 mg/L PBTK NA 50% Rat Human +DTXSID1057795 Css NA 0.2551 mg/L PBTK NA 95% Rat Human +DTXSID1057797 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057797 Fup 0.0958 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057797 Vd NA 1.506 L/kg 1compartment NA NA Human Human +DTXSID1057797 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1057797 TK.Half.Life NA 4.409 hours 1compartment NA NA Human Human +DTXSID1057797 Css NA 0.3214 mg/L 3compartmentss NA 50% Human Human +DTXSID1057797 Css NA 2.462 mg/L 3compartmentss NA 95% Human Human +DTXSID1057797 Css NA 0.2123 mg/L PBTK NA 50% Human Human +DTXSID1057797 Css NA 1.548 mg/L PBTK NA 95% Human Human +DTXSID1057797 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057797 Fup 0.0958 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057797 Vd NA 1.156 L/kg 1compartment NA NA Rat Human +DTXSID1057797 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1057797 TK.Half.Life NA 1.717 hours 1compartment NA NA Rat Human +DTXSID1057797 Css NA 0.04152 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057797 Css NA 0.2465 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057797 Css NA 0.027 mg/L PBTK NA 50% Rat Human +DTXSID1057797 Css NA 0.1505 mg/L PBTK NA 95% Rat Human +DTXSID1057799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057799 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057799 Vd NA 2.073 L/kg 1compartment NA NA Human Human DTXSID1057799 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057799 TK.Half.Life NA 7.437 hours 1compartment NA NA Human Human -DTXSID1057799 Css NA 0.401 mg/L 3compartmentss NA 50% Human Human -DTXSID1057799 Css NA 2.422 mg/L 3compartmentss NA 95% Human Human -DTXSID1057799 Css NA 0.3286 mg/L PBTK NA 50% Human Human -DTXSID1057799 Css NA 1.715 mg/L PBTK NA 95% Human Human -DTXSID1057799 Clint NA 4.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057799 Fup NA 0.1871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057799 Vd NA 1.692 L/kg 1compartment NA NA Rat Human +DTXSID1057799 TK.Half.Life NA 2.604 hours 1compartment NA NA Human Human +DTXSID1057799 Css NA 0.06215 mg/L 3compartmentss NA 50% Human Human +DTXSID1057799 Css NA 0.5267 mg/L 3compartmentss NA 95% Human Human +DTXSID1057799 Css NA 0.05574 mg/L PBTK NA 50% Human Human +DTXSID1057799 Css NA 0.396 mg/L PBTK NA 95% Human Human +DTXSID1057799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057799 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057799 Vd NA 2.067 L/kg 1compartment NA NA Rat Human DTXSID1057799 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057799 TK.Half.Life NA 4.338 hours 1compartment NA NA Rat Human -DTXSID1057799 Css NA 0.1996 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057799 Css NA 0.8824 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057799 Css NA 0.1584 mg/L PBTK NA 50% Rat Human -DTXSID1057799 Css NA 0.5844 mg/L PBTK NA 95% Rat Human -DTXSID1057820 Clint NA 102.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057820 Fup NA 0.1949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057820 Vd NA 1.077 L/kg 1compartment NA NA Human Human +DTXSID1057799 TK.Half.Life NA 1.434 hours 1compartment NA NA Rat Human +DTXSID1057799 Css NA 0.007866 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057799 Css NA 0.04683 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057799 Css NA 0.007104 mg/L PBTK NA 50% Rat Human +DTXSID1057799 Css NA 0.03675 mg/L PBTK NA 95% Rat Human +DTXSID1057820 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057820 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057820 Vd NA 1.063 L/kg 1compartment NA NA Human Human DTXSID1057820 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057820 TK.Half.Life NA 1.012 hours 1compartment NA NA Human Human -DTXSID1057820 Css NA 0.02319 mg/L 3compartmentss NA 50% Human Human -DTXSID1057820 Css NA 0.1706 mg/L 3compartmentss NA 95% Human Human -DTXSID1057820 Css NA 0.01697 mg/L PBTK NA 50% Human Human -DTXSID1057820 Css NA 0.119 mg/L PBTK NA 95% Human Human -DTXSID1057820 Clint NA 102.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057820 Fup NA 0.1949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057820 Vd NA 1.049 L/kg 1compartment NA NA Rat Human +DTXSID1057820 TK.Half.Life NA 4.26 hours 1compartment NA NA Human Human +DTXSID1057820 Css NA 0.3861 mg/L 3compartmentss NA 50% Human Human +DTXSID1057820 Css NA 2.41 mg/L 3compartmentss NA 95% Human Human +DTXSID1057820 Css NA 0.2809 mg/L PBTK NA 50% Human Human +DTXSID1057820 Css NA 1.584 mg/L PBTK NA 95% Human Human +DTXSID1057820 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057820 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057820 Vd NA 1.027 L/kg 1compartment NA NA Rat Human DTXSID1057820 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057820 TK.Half.Life NA 0.477 hours 1compartment NA NA Rat Human -DTXSID1057820 Css NA 0.01282 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057820 Css NA 0.07907 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057820 Css NA 0.009069 mg/L PBTK NA 50% Rat Human -DTXSID1057820 Css NA 0.05167 mg/L PBTK NA 95% Rat Human +DTXSID1057820 TK.Half.Life NA 2.435 hours 1compartment NA NA Rat Human +DTXSID1057820 Css NA 0.04657 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057820 Css NA 0.2031 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057820 Css NA 0.03317 mg/L PBTK NA 50% Rat Human +DTXSID1057820 Css NA 0.1309 mg/L PBTK NA 95% Rat Human DTXSID1057822 Clint NA 0.4852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID1057822 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057822 Vd NA 2.81 L/kg 1compartment NA NA Human Human -DTXSID1057822 Days.Css NA 125 Days PBTK NA NA Human Human -DTXSID1057822 TK.Half.Life NA 529.5 hours 1compartment NA NA Human Human -DTXSID1057822 Css NA 23.62 mg/L 3compartmentss NA 50% Human Human -DTXSID1057822 Css NA 79.19 mg/L 3compartmentss NA 95% Human Human -DTXSID1057822 Css NA 16.44 mg/L PBTK NA 50% Human Human -DTXSID1057822 Css NA 51.57 mg/L PBTK NA 95% Human Human +DTXSID1057822 Vd NA 2.655 L/kg 1compartment NA NA Human Human +DTXSID1057822 Days.Css NA 86 Days PBTK NA NA Human Human +DTXSID1057822 TK.Half.Life NA 377.7 hours 1compartment NA NA Human Human +DTXSID1057822 Css NA 17.95 mg/L 3compartmentss NA 50% Human Human +DTXSID1057822 Css NA 61.5 mg/L 3compartmentss NA 95% Human Human +DTXSID1057822 Css NA 12.37 mg/L PBTK NA 50% Human Human +DTXSID1057822 Css NA 39.33 mg/L PBTK NA 95% Human Human DTXSID1057822 Clint NA 0.4852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID1057822 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057822 Vd NA 2.11 L/kg 1compartment NA NA Rat Human -DTXSID1057822 Days.Css NA 47 Days PBTK NA NA Rat Human -DTXSID1057822 TK.Half.Life NA 73.09 hours 1compartment NA NA Rat Human -DTXSID1057822 Css NA 9.578 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057822 Css NA 23.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057822 Css NA 6.326 mg/L PBTK NA 50% Rat Human -DTXSID1057822 Css NA 14.34 mg/L PBTK NA 95% Rat Human -DTXSID1057824 Clint NA 4.752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057824 Fup NA 0.1604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057824 Vd NA 1.612 L/kg 1compartment NA NA Human Human -DTXSID1057824 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057824 TK.Half.Life NA 7.149 hours 1compartment NA NA Human Human -DTXSID1057824 Css NA 0.44 mg/L 3compartmentss NA 50% Human Human -DTXSID1057824 Css NA 3.207 mg/L 3compartmentss NA 95% Human Human -DTXSID1057824 Css NA 0.3694 mg/L PBTK NA 50% Human Human -DTXSID1057824 Css NA 2.26 mg/L PBTK NA 95% Human Human -DTXSID1057824 Clint NA 4.752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057824 Fup NA 0.1604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057824 Vd NA 1.582 L/kg 1compartment NA NA Rat Human +DTXSID1057822 Vd NA 1.994 L/kg 1compartment NA NA Rat Human +DTXSID1057822 Days.Css NA 31 Days PBTK NA NA Rat Human +DTXSID1057822 TK.Half.Life NA 58.74 hours 1compartment NA NA Rat Human +DTXSID1057822 Css NA 1.631 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057822 Css NA 4.305 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057822 Css NA 1.107 mg/L PBTK NA 50% Rat Human +DTXSID1057822 Css NA 2.643 mg/L PBTK NA 95% Rat Human +DTXSID1057824 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057824 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057824 Vd NA 1.563 L/kg 1compartment NA NA Human Human +DTXSID1057824 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID1057824 TK.Half.Life NA 25.47 hours 1compartment NA NA Human Human +DTXSID1057824 Css NA 1.27 mg/L 3compartmentss NA 50% Human Human +DTXSID1057824 Css NA 6.234 mg/L 3compartmentss NA 95% Human Human +DTXSID1057824 Css NA 1.162 mg/L PBTK NA 50% Human Human +DTXSID1057824 Css NA 4.415 mg/L PBTK NA 95% Human Human +DTXSID1057824 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057824 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057824 Vd NA 1.543 L/kg 1compartment NA NA Rat Human DTXSID1057824 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057824 TK.Half.Life NA 4.234 hours 1compartment NA NA Rat Human -DTXSID1057824 Css NA 0.2213 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057824 Css NA 1.213 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057824 Css NA 0.1803 mg/L PBTK NA 50% Rat Human -DTXSID1057824 Css NA 0.7864 mg/L PBTK NA 95% Rat Human -DTXSID1057826 Clint NA 7.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057826 Fup NA 0.0598 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057826 Vd NA 0.2501 L/kg 1compartment NA NA Human Human +DTXSID1057824 TK.Half.Life NA 8.57 hours 1compartment NA NA Rat Human +DTXSID1057824 Css NA 0.0301 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057824 Css NA 0.201 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057824 Css NA 0.02816 mg/L PBTK NA 50% Rat Human +DTXSID1057824 Css NA 0.144 mg/L PBTK NA 95% Rat Human +DTXSID1057826 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057826 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057826 Vd NA 0.3594 L/kg 1compartment NA NA Human Human DTXSID1057826 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID1057826 TK.Half.Life NA 2.194 hours 1compartment NA NA Human Human -DTXSID1057826 Css NA 1.458 mg/L 3compartmentss NA 50% Human Human -DTXSID1057826 Css NA 9.918 mg/L 3compartmentss NA 95% Human Human -DTXSID1057826 Css NA 0.8824 mg/L PBTK NA 50% Human Human -DTXSID1057826 Css NA 5.81 mg/L PBTK NA 95% Human Human -DTXSID1057826 Clint NA 7.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057826 Fup NA 0.0598 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057826 Vd NA 0.2428 L/kg 1compartment NA NA Rat Human +DTXSID1057826 TK.Half.Life NA 0.7267 hours 1compartment NA NA Human Human +DTXSID1057826 Css NA 0.1777 mg/L 3compartmentss NA 50% Human Human +DTXSID1057826 Css NA 1.46 mg/L 3compartmentss NA 95% Human Human +DTXSID1057826 Css NA 0.1141 mg/L PBTK NA 50% Human Human +DTXSID1057826 Css NA 0.905 mg/L PBTK NA 95% Human Human +DTXSID1057826 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057826 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057826 Vd NA 0.3479 L/kg 1compartment NA NA Rat Human DTXSID1057826 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057826 TK.Half.Life NA 1.332 hours 1compartment NA NA Rat Human -DTXSID1057826 Css NA 0.7742 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057826 Css NA 4.026 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057826 Css NA 0.4372 mg/L PBTK NA 50% Rat Human -DTXSID1057826 Css NA 2.202 mg/L PBTK NA 95% Rat Human -DTXSID1057828 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057828 Fup NA 0.286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID1057828 Vd NA 0.7864 L/kg 1compartment NA NA Human Human -DTXSID1057828 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID1057828 TK.Half.Life NA 18.53 hours 1compartment NA NA Human Human -DTXSID1057828 Css NA 2.682 mg/L 3compartmentss NA 50% Human Human -DTXSID1057828 Css NA 10.42 mg/L 3compartmentss NA 95% Human Human -DTXSID1057828 Css NA 1.936 mg/L PBTK NA 50% Human Human -DTXSID1057828 Css NA 6.687 mg/L PBTK NA 95% Human Human -DTXSID1057828 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057828 Fup NA 0.286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID1057828 Vd NA 0.7029 L/kg 1compartment NA NA Rat Human +DTXSID1057826 TK.Half.Life NA 0.4032 hours 1compartment NA NA Rat Human +DTXSID1057826 Css NA 0.02336 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057826 Css NA 0.1428 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057826 Css NA 0.01462 mg/L PBTK NA 50% Rat Human +DTXSID1057826 Css NA 0.08575 mg/L PBTK NA 95% Rat Human +DTXSID1057828 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057828 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1057828 Vd NA 1.209 L/kg 1compartment NA NA Human Human +DTXSID1057828 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1057828 TK.Half.Life NA 14.03 hours 1compartment NA NA Human Human +DTXSID1057828 Css NA 1.026 mg/L 3compartmentss NA 50% Human Human +DTXSID1057828 Css NA 6.903 mg/L 3compartmentss NA 95% Human Human +DTXSID1057828 Css NA 0.8853 mg/L PBTK NA 50% Human Human +DTXSID1057828 Css NA 4.518 mg/L PBTK NA 95% Human Human +DTXSID1057828 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057828 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1057828 Vd NA 1.089 L/kg 1compartment NA NA Rat Human DTXSID1057828 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID1057828 TK.Half.Life NA 5.471 hours 1compartment NA NA Rat Human -DTXSID1057828 Css NA 0.7342 mg/L 3compartmentss NA 50% Rat Human -DTXSID1057828 Css NA 2.446 mg/L 3compartmentss NA 95% Rat Human -DTXSID1057828 Css NA 0.5078 mg/L PBTK NA 50% Rat Human -DTXSID1057828 Css NA 1.451 mg/L PBTK NA 95% Rat Human -DTXSID10858817 Clint NA 82.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID10858817 Fup NA 0.5123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID10858817 Vd NA 1.296 L/kg 1compartment NA NA Human Human +DTXSID1057828 TK.Half.Life NA 4.039 hours 1compartment NA NA Rat Human +DTXSID1057828 Css NA 0.02574 mg/L 3compartmentss NA 50% Rat Human +DTXSID1057828 Css NA 0.2218 mg/L 3compartmentss NA 95% Rat Human +DTXSID1057828 Css NA 0.02204 mg/L PBTK NA 50% Rat Human +DTXSID1057828 Css NA 0.1426 mg/L PBTK NA 95% Rat Human +DTXSID10586183 Clint 1.069 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10586183 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10586183 Vd NA 2.402 L/kg 1compartment NA NA Human Human +DTXSID10586183 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID10586183 TK.Half.Life NA 28.31 hours 1compartment NA NA Human Human +DTXSID10586183 Css NA 1.115 mg/L 3compartmentss NA 50% Human Human +DTXSID10586183 Css NA 4.721 mg/L 3compartmentss NA 95% Human Human +DTXSID10586183 Css NA 0.948 mg/L PBTK NA 50% Human Human +DTXSID10586183 Css NA 3.44 mg/L PBTK NA 95% Human Human +DTXSID10586183 Clint 1.069 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10586183 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10586183 Vd NA 2.092 L/kg 1compartment NA NA Rat Human +DTXSID10586183 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID10586183 TK.Half.Life NA 9.61 hours 1compartment NA NA Rat Human +DTXSID10586183 Css NA 0.1046 mg/L 3compartmentss NA 50% Rat Human +DTXSID10586183 Css NA 0.3529 mg/L 3compartmentss NA 95% Rat Human +DTXSID10586183 Css NA 0.08938 mg/L PBTK NA 50% Rat Human +DTXSID10586183 Css NA 0.2415 mg/L PBTK NA 95% Rat Human +DTXSID1058688 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1058688 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1058688 Vd NA 0.6269 L/kg 1compartment NA NA Human Human +DTXSID1058688 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID1058688 TK.Half.Life NA 10.12 hours 1compartment NA NA Human Human +DTXSID1058688 Css NA 1.75 mg/L 3compartmentss NA 50% Human Human +DTXSID1058688 Css NA 7.75 mg/L 3compartmentss NA 95% Human Human +DTXSID1058688 Css NA 1.304 mg/L PBTK NA 50% Human Human +DTXSID1058688 Css NA 4.91 mg/L PBTK NA 95% Human Human +DTXSID1058688 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1058688 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1058688 Vd NA 0.6134 L/kg 1compartment NA NA Rat Human +DTXSID1058688 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1058688 TK.Half.Life NA 3.353 hours 1compartment NA NA Rat Human +DTXSID1058688 Css NA 0.1114 mg/L 3compartmentss NA 50% Rat Human +DTXSID1058688 Css NA 0.422 mg/L 3compartmentss NA 95% Rat Human +DTXSID1058688 Css NA 0.08212 mg/L PBTK NA 50% Rat Human +DTXSID1058688 Css NA 0.2598 mg/L PBTK NA 95% Rat Human +DTXSID1059074 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1059074 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1059074 Vd NA 0.1923 L/kg 1compartment NA NA Human Human +DTXSID1059074 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1059074 TK.Half.Life NA 2.021 hours 1compartment NA NA Human Human +DTXSID1059074 Css NA 1.782 mg/L 3compartmentss NA 50% Human Human +DTXSID1059074 Css NA 17.17 mg/L 3compartmentss NA 95% Human Human +DTXSID1059074 Css NA 1.048 mg/L PBTK NA 50% Human Human +DTXSID1059074 Css NA 10.06 mg/L PBTK NA 95% Human Human +DTXSID1059074 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1059074 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1059074 Vd NA 0.1934 L/kg 1compartment NA NA Rat Human +DTXSID1059074 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1059074 TK.Half.Life NA 0.8357 hours 1compartment NA NA Rat Human +DTXSID1059074 Css NA 0.1442 mg/L 3compartmentss NA 50% Rat Human +DTXSID1059074 Css NA 1.088 mg/L 3compartmentss NA 95% Rat Human +DTXSID1059074 Css NA 0.08145 mg/L PBTK NA 50% Rat Human +DTXSID1059074 Css NA 0.6098 mg/L PBTK NA 95% Rat Human +DTXSID1059311 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1059311 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1059311 Vd NA 1.147 L/kg 1compartment NA NA Human Human +DTXSID1059311 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1059311 TK.Half.Life NA 18.32 hours 1compartment NA NA Human Human +DTXSID1059311 Css NA 1.543 mg/L 3compartmentss NA 50% Human Human +DTXSID1059311 Css NA 7.206 mg/L 3compartmentss NA 95% Human Human +DTXSID1059311 Css NA 1.29 mg/L PBTK NA 50% Human Human +DTXSID1059311 Css NA 4.761 mg/L PBTK NA 95% Human Human +DTXSID1059311 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1059311 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1059311 Vd NA 1.132 L/kg 1compartment NA NA Rat Human +DTXSID1059311 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1059311 TK.Half.Life NA 6.161 hours 1compartment NA NA Rat Human +DTXSID1059311 Css NA 0.09723 mg/L 3compartmentss NA 50% Rat Human +DTXSID1059311 Css NA 0.4072 mg/L 3compartmentss NA 95% Rat Human +DTXSID1059311 Css NA 0.08095 mg/L PBTK NA 50% Rat Human +DTXSID1059311 Css NA 0.2624 mg/L PBTK NA 95% Rat Human +DTXSID1060429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1060429 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1060429 Vd NA 1.835 L/kg 1compartment NA NA Human Human +DTXSID1060429 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1060429 TK.Half.Life NA 2.297 hours 1compartment NA NA Human Human +DTXSID1060429 Css NA 0.06451 mg/L 3compartmentss NA 50% Human Human +DTXSID1060429 Css NA 0.4667 mg/L 3compartmentss NA 95% Human Human +DTXSID1060429 Css NA 0.05092 mg/L PBTK NA 50% Human Human +DTXSID1060429 Css NA 0.3347 mg/L PBTK NA 95% Human Human +DTXSID1060429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1060429 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1060429 Vd NA 1.475 L/kg 1compartment NA NA Rat Human +DTXSID1060429 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1060429 TK.Half.Life NA 0.8513 hours 1compartment NA NA Rat Human +DTXSID1060429 Css NA 0.007909 mg/L 3compartmentss NA 50% Rat Human +DTXSID1060429 Css NA 0.04568 mg/L 3compartmentss NA 95% Rat Human +DTXSID1060429 Css NA 0.006329 mg/L PBTK NA 50% Rat Human +DTXSID1060429 Css NA 0.033 mg/L PBTK NA 95% Rat Human +DTXSID1060556 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1060556 Fup 0.0954 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1060556 Vd NA 1.759 L/kg 1compartment NA NA Human Human +DTXSID1060556 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1060556 TK.Half.Life NA 5.536 hours 1compartment NA NA Human Human +DTXSID1060556 Css NA 0.3498 mg/L 3compartmentss NA 50% Human Human +DTXSID1060556 Css NA 2.563 mg/L 3compartmentss NA 95% Human Human +DTXSID1060556 Css NA 0.2318 mg/L PBTK NA 50% Human Human +DTXSID1060556 Css NA 1.643 mg/L PBTK NA 95% Human Human +DTXSID1060556 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1060556 Fup 0.0954 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1060556 Vd NA 1.336 L/kg 1compartment NA NA Rat Human +DTXSID1060556 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1060556 TK.Half.Life NA 1.991 hours 1compartment NA NA Rat Human +DTXSID1060556 Css NA 0.04442 mg/L 3compartmentss NA 50% Rat Human +DTXSID1060556 Css NA 0.2494 mg/L 3compartmentss NA 95% Rat Human +DTXSID1060556 Css NA 0.0292 mg/L PBTK NA 50% Rat Human +DTXSID1060556 Css NA 0.1577 mg/L PBTK NA 95% Rat Human +DTXSID1060687 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1060687 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1060687 Vd NA 0.4123 L/kg 1compartment NA NA Human Human +DTXSID1060687 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID1060687 TK.Half.Life NA 17.78 hours 1compartment NA NA Human Human +DTXSID1060687 Css NA 3.24 mg/L 3compartmentss NA 50% Human Human +DTXSID1060687 Css NA 15.95 mg/L 3compartmentss NA 95% Human Human +DTXSID1060687 Css NA 2.157 mg/L PBTK NA 50% Human Human +DTXSID1060687 Css NA 9.834 mg/L PBTK NA 95% Human Human +DTXSID1060687 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1060687 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1060687 Vd NA 0.4075 L/kg 1compartment NA NA Rat Human +DTXSID1060687 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1060687 TK.Half.Life NA 5.991 hours 1compartment NA NA Rat Human +DTXSID1060687 Css NA 0.01802 mg/L 3compartmentss NA 50% Rat Human +DTXSID1060687 Css NA 0.08929 mg/L 3compartmentss NA 95% Rat Human +DTXSID1060687 Css NA 0.01135 mg/L PBTK NA 50% Rat Human +DTXSID1060687 Css NA 0.05194 mg/L PBTK NA 95% Rat Human +DTXSID1061025 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1061025 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1061025 Vd NA 0.6928 L/kg 1compartment NA NA Human Human +DTXSID1061025 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID1061025 TK.Half.Life NA 0.8312 hours 1compartment NA NA Human Human +DTXSID1061025 Css NA 0.05605 mg/L 3compartmentss NA 50% Human Human +DTXSID1061025 Css NA 0.4378 mg/L 3compartmentss NA 95% Human Human +DTXSID1061025 Css NA 0.04142 mg/L PBTK NA 50% Human Human +DTXSID1061025 Css NA 0.2956 mg/L PBTK NA 95% Human Human +DTXSID1061025 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1061025 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1061025 Vd NA 0.6529 L/kg 1compartment NA NA Rat Human +DTXSID1061025 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID1061025 TK.Half.Life NA 0.4077 hours 1compartment NA NA Rat Human +DTXSID1061025 Css NA 0.00704 mg/L 3compartmentss NA 50% Rat Human +DTXSID1061025 Css NA 0.04248 mg/L 3compartmentss NA 95% Rat Human +DTXSID1061025 Css NA 0.005129 mg/L PBTK NA 50% Rat Human +DTXSID1061025 Css NA 0.02858 mg/L PBTK NA 95% Rat Human +DTXSID10623421 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10623421 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10623421 Vd NA 2.199 L/kg 1compartment NA NA Human Human +DTXSID10623421 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10623421 TK.Half.Life NA 2.883 hours 1compartment NA NA Human Human +DTXSID10623421 Css NA 0.0815 mg/L 3compartmentss NA 50% Human Human +DTXSID10623421 Css NA 0.7849 mg/L 3compartmentss NA 95% Human Human +DTXSID10623421 Css NA 0.07522 mg/L PBTK NA 50% Human Human +DTXSID10623421 Css NA 0.5915 mg/L PBTK NA 95% Human Human +DTXSID10623421 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10623421 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10623421 Vd NA 2.168 L/kg 1compartment NA NA Rat Human +DTXSID10623421 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10623421 TK.Half.Life NA 1.64 hours 1compartment NA NA Rat Human +DTXSID10623421 Css NA 0.01016 mg/L 3compartmentss NA 50% Rat Human +DTXSID10623421 Css NA 0.08236 mg/L 3compartmentss NA 95% Rat Human +DTXSID10623421 Css NA 0.009505 mg/L PBTK NA 50% Rat Human +DTXSID10623421 Css NA 0.06013 mg/L PBTK NA 95% Rat Human +DTXSID1074755 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1074755 Fup 0.0174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID1074755 Vd NA 3.06 L/kg 1compartment NA NA Human Human +DTXSID1074755 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID1074755 TK.Half.Life NA 73.78 hours 1compartment NA NA Human Human +DTXSID1074755 Css NA 2.923 mg/L 3compartmentss NA 50% Human Human +DTXSID1074755 Css NA 19.54 mg/L 3compartmentss NA 95% Human Human +DTXSID1074755 Css NA 2.015 mg/L PBTK NA 50% Human Human +DTXSID1074755 Css NA 13.05 mg/L PBTK NA 95% Human Human +DTXSID1074755 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1074755 Fup 0.0174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID1074755 Vd NA 2.292 L/kg 1compartment NA NA Rat Human +DTXSID1074755 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID1074755 TK.Half.Life NA 10.84 hours 1compartment NA NA Rat Human +DTXSID1074755 Css NA 0.38 mg/L 3compartmentss NA 50% Rat Human +DTXSID1074755 Css NA 2.161 mg/L 3compartmentss NA 95% Rat Human +DTXSID1074755 Css NA 0.2596 mg/L PBTK NA 50% Rat Human +DTXSID1074755 Css NA 1.468 mg/L PBTK NA 95% Rat Human +DTXSID10858791 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10858791 Fup 0.684 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10858791 Vd NA 1.665 L/kg 1compartment NA NA Human Human +DTXSID10858791 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID10858791 TK.Half.Life NA 17.33 hours 1compartment NA NA Human Human +DTXSID10858791 Css NA 0.988 mg/L 3compartmentss NA 50% Human Human +DTXSID10858791 Css NA 7.034 mg/L 3compartmentss NA 95% Human Human +DTXSID10858791 Css NA 0.9236 mg/L PBTK NA 50% Human Human +DTXSID10858791 Css NA 4.732 mg/L PBTK NA 95% Human Human +DTXSID10858791 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10858791 Fup 0.684 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10858791 Vd NA 1.555 L/kg 1compartment NA NA Rat Human +DTXSID10858791 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10858791 TK.Half.Life NA 5.134 hours 1compartment NA NA Rat Human +DTXSID10858791 Css NA 0.05916 mg/L 3compartmentss NA 50% Rat Human +DTXSID10858791 Css NA 0.3931 mg/L 3compartmentss NA 95% Rat Human +DTXSID10858791 Css NA 0.05594 mg/L PBTK NA 50% Rat Human +DTXSID10858791 Css NA 0.2534 mg/L PBTK NA 95% Rat Human +DTXSID10858817 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10858817 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10858817 Vd NA 1.038 L/kg 1compartment NA NA Human Human DTXSID10858817 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID10858817 TK.Half.Life NA 0.9428 hours 1compartment NA NA Human Human -DTXSID10858817 Css NA 0.01109 mg/L 3compartmentss NA 50% Human Human -DTXSID10858817 Css NA 0.1022 mg/L 3compartmentss NA 95% Human Human -DTXSID10858817 Css NA 0.009082 mg/L PBTK NA 50% Human Human -DTXSID10858817 Css NA 0.07296 mg/L PBTK NA 95% Human Human -DTXSID10858817 Clint NA 82.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID10858817 Fup NA 0.5123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID10858817 Vd NA 1.128 L/kg 1compartment NA NA Rat Human +DTXSID10858817 TK.Half.Life NA 2.905 hours 1compartment NA NA Human Human +DTXSID10858817 Css NA 0.217 mg/L 3compartmentss NA 50% Human Human +DTXSID10858817 Css NA 1.384 mg/L 3compartmentss NA 95% Human Human +DTXSID10858817 Css NA 0.1588 mg/L PBTK NA 50% Human Human +DTXSID10858817 Css NA 0.9174 mg/L PBTK NA 95% Human Human +DTXSID10858817 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10858817 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10858817 Vd NA 0.8794 L/kg 1compartment NA NA Rat Human DTXSID10858817 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID10858817 TK.Half.Life NA 0.3723 hours 1compartment NA NA Rat Human -DTXSID10858817 Css NA 0.005879 mg/L 3compartmentss NA 50% Rat Human -DTXSID10858817 Css NA 0.04728 mg/L 3compartmentss NA 95% Rat Human -DTXSID10858817 Css NA 0.004765 mg/L PBTK NA 50% Rat Human -DTXSID10858817 Css NA 0.03243 mg/L PBTK NA 95% Rat Human -DTXSID10859960 Clint NA 5.443 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID10859960 Fup NA 0.1374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID10859960 Vd NA 3.445 L/kg 1compartment NA NA Human Human +DTXSID10858817 TK.Half.Life NA 1.345 hours 1compartment NA NA Rat Human +DTXSID10858817 Css NA 0.009549 mg/L 3compartmentss NA 50% Rat Human +DTXSID10858817 Css NA 0.06971 mg/L 3compartmentss NA 95% Rat Human +DTXSID10858817 Css NA 0.006989 mg/L PBTK NA 50% Rat Human +DTXSID10858817 Css NA 0.04566 mg/L PBTK NA 95% Rat Human +DTXSID10859960 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10859960 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10859960 Vd NA 4.486 L/kg 1compartment NA NA Human Human DTXSID10859960 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID10859960 TK.Half.Life NA 12.4 hours 1compartment NA NA Human Human -DTXSID10859960 Css NA 0.318 mg/L 3compartmentss NA 50% Human Human -DTXSID10859960 Css NA 2.655 mg/L 3compartmentss NA 95% Human Human -DTXSID10859960 Css NA 0.3197 mg/L PBTK NA 50% Human Human -DTXSID10859960 Css NA 2.143 mg/L PBTK NA 95% Human Human -DTXSID10859960 Clint NA 5.443 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID10859960 Fup NA 0.1374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID10859960 Vd NA 3.379 L/kg 1compartment NA NA Rat Human +DTXSID10859960 TK.Half.Life NA 4.522 hours 1compartment NA NA Human Human +DTXSID10859960 Css NA 0.04032 mg/L 3compartmentss NA 50% Human Human +DTXSID10859960 Css NA 0.3025 mg/L 3compartmentss NA 95% Human Human +DTXSID10859960 Css NA 0.04963 mg/L PBTK NA 50% Human Human +DTXSID10859960 Css NA 0.3128 mg/L PBTK NA 95% Human Human +DTXSID10859960 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10859960 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10859960 Vd NA 4.401 L/kg 1compartment NA NA Rat Human DTXSID10859960 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID10859960 TK.Half.Life NA 6.849 hours 1compartment NA NA Rat Human -DTXSID10859960 Css NA 0.1624 mg/L 3compartmentss NA 50% Rat Human -DTXSID10859960 Css NA 1.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID10859960 Css NA 0.1609 mg/L PBTK NA 50% Rat Human -DTXSID10859960 Css NA 0.8005 mg/L PBTK NA 95% Rat Human +DTXSID10859960 TK.Half.Life NA 2.233 hours 1compartment NA NA Rat Human +DTXSID10859960 Css NA 0.004898 mg/L 3compartmentss NA 50% Rat Human +DTXSID10859960 Css NA 0.03064 mg/L 3compartmentss NA 95% Rat Human +DTXSID10859960 Css NA 0.006332 mg/L PBTK NA 50% Rat Human +DTXSID10859960 Css NA 0.03317 mg/L PBTK NA 95% Rat Human +DTXSID10862919 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10862919 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10862919 Vd NA 0.9711 L/kg 1compartment NA NA Human Human +DTXSID10862919 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10862919 TK.Half.Life NA 9.686 hours 1compartment NA NA Human Human +DTXSID10862919 Css NA 1.073 mg/L 3compartmentss NA 50% Human Human +DTXSID10862919 Css NA 7.265 mg/L 3compartmentss NA 95% Human Human +DTXSID10862919 Css NA 0.9012 mg/L PBTK NA 50% Human Human +DTXSID10862919 Css NA 4.672 mg/L PBTK NA 95% Human Human +DTXSID10862919 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10862919 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10862919 Vd NA 0.9851 L/kg 1compartment NA NA Rat Human +DTXSID10862919 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10862919 TK.Half.Life NA 3.342 hours 1compartment NA NA Rat Human +DTXSID10862919 Css NA 0.06452 mg/L 3compartmentss NA 50% Rat Human +DTXSID10862919 Css NA 0.4144 mg/L 3compartmentss NA 95% Rat Human +DTXSID10862919 Css NA 0.05422 mg/L PBTK NA 50% Rat Human +DTXSID10862919 Css NA 0.2565 mg/L PBTK NA 95% Rat Human +DTXSID10863345 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10863345 Fup 0.0518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10863345 Vd NA 0.9953 L/kg 1compartment NA NA Human Human +DTXSID10863345 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10863345 TK.Half.Life NA 4.206 hours 1compartment NA NA Human Human +DTXSID10863345 Css NA 0.57 mg/L 3compartmentss NA 50% Human Human +DTXSID10863345 Css NA 4.643 mg/L 3compartmentss NA 95% Human Human +DTXSID10863345 Css NA 0.3564 mg/L PBTK NA 50% Human Human +DTXSID10863345 Css NA 2.802 mg/L PBTK NA 95% Human Human +DTXSID10863345 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10863345 Fup 0.0518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10863345 Vd NA 0.7648 L/kg 1compartment NA NA Rat Human +DTXSID10863345 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10863345 TK.Half.Life NA 1.859 hours 1compartment NA NA Rat Human +DTXSID10863345 Css NA 0.07536 mg/L 3compartmentss NA 50% Rat Human +DTXSID10863345 Css NA 0.4826 mg/L 3compartmentss NA 95% Rat Human +DTXSID10863345 Css NA 0.04576 mg/L PBTK NA 50% Rat Human +DTXSID10863345 Css NA 0.2799 mg/L PBTK NA 95% Rat Human +DTXSID10866755 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10866755 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10866755 Vd NA 1.345 L/kg 1compartment NA NA Human Human +DTXSID10866755 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10866755 TK.Half.Life NA 2.136 hours 1compartment NA NA Human Human +DTXSID10866755 Css NA 0.115 mg/L 3compartmentss NA 50% Human Human +DTXSID10866755 Css NA 1.027 mg/L 3compartmentss NA 95% Human Human +DTXSID10866755 Css NA 0.09794 mg/L PBTK NA 50% Human Human +DTXSID10866755 Css NA 0.7179 mg/L PBTK NA 95% Human Human +DTXSID10866755 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10866755 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10866755 Vd NA 1.231 L/kg 1compartment NA NA Rat Human +DTXSID10866755 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10866755 TK.Half.Life NA 1.031 hours 1compartment NA NA Rat Human +DTXSID10866755 Css NA 0.01289 mg/L 3compartmentss NA 50% Rat Human +DTXSID10866755 Css NA 0.1012 mg/L 3compartmentss NA 95% Rat Human +DTXSID10866755 Css NA 0.01117 mg/L PBTK NA 50% Rat Human +DTXSID10866755 Css NA 0.06632 mg/L PBTK NA 95% Rat Human +DTXSID10867747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10867747 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10867747 Vd NA 2.811 L/kg 1compartment NA NA Human Human +DTXSID10867747 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10867747 TK.Half.Life NA 9.926 hours 1compartment NA NA Human Human +DTXSID10867747 Css NA 0.3236 mg/L 3compartmentss NA 50% Human Human +DTXSID10867747 Css NA 2.108 mg/L 3compartmentss NA 95% Human Human +DTXSID10867747 Css NA 0.234 mg/L PBTK NA 50% Human Human +DTXSID10867747 Css NA 1.431 mg/L PBTK NA 95% Human Human +DTXSID10867747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10867747 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10867747 Vd NA 2.13 L/kg 1compartment NA NA Rat Human +DTXSID10867747 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10867747 TK.Half.Life NA 2.236 hours 1compartment NA NA Rat Human +DTXSID10867747 Css NA 0.04102 mg/L 3compartmentss NA 50% Rat Human +DTXSID10867747 Css NA 0.2058 mg/L 3compartmentss NA 95% Rat Human +DTXSID10867747 Css NA 0.02953 mg/L PBTK NA 50% Rat Human +DTXSID10867747 Css NA 0.1419 mg/L PBTK NA 95% Rat Human +DTXSID10868613 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10868613 Fup 0.017 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10868613 Vd NA 2.006 L/kg 1compartment NA NA Human Human +DTXSID10868613 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID10868613 TK.Half.Life NA 22.45 hours 1compartment NA NA Human Human +DTXSID10868613 Css NA 1.668 mg/L 3compartmentss NA 50% Human Human +DTXSID10868613 Css NA 14.27 mg/L 3compartmentss NA 95% Human Human +DTXSID10868613 Css NA 1.075 mg/L PBTK NA 50% Human Human +DTXSID10868613 Css NA 8.87 mg/L PBTK NA 95% Human Human +DTXSID10868613 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10868613 Fup 0.017 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10868613 Vd NA 1.508 L/kg 1compartment NA NA Rat Human +DTXSID10868613 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID10868613 TK.Half.Life NA 7.45 hours 1compartment NA NA Rat Human +DTXSID10868613 Css NA 0.2154 mg/L 3compartmentss NA 50% Rat Human +DTXSID10868613 Css NA 1.467 mg/L 3compartmentss NA 95% Rat Human +DTXSID10868613 Css NA 0.1359 mg/L PBTK NA 50% Rat Human +DTXSID10868613 Css NA 0.8818 mg/L PBTK NA 95% Rat Human +DTXSID10869029 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10869029 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10869029 Vd NA 2.364 L/kg 1compartment NA NA Human Human +DTXSID10869029 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10869029 TK.Half.Life NA 3.961 hours 1compartment NA NA Human Human +DTXSID10869029 Css NA 0.1102 mg/L 3compartmentss NA 50% Human Human +DTXSID10869029 Css NA 0.7386 mg/L 3compartmentss NA 95% Human Human +DTXSID10869029 Css NA 0.08418 mg/L PBTK NA 50% Human Human +DTXSID10869029 Css NA 0.532 mg/L PBTK NA 95% Human Human +DTXSID10869029 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10869029 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10869029 Vd NA 1.835 L/kg 1compartment NA NA Rat Human +DTXSID10869029 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10869029 TK.Half.Life NA 1.23 hours 1compartment NA NA Rat Human +DTXSID10869029 Css NA 0.01366 mg/L 3compartmentss NA 50% Rat Human +DTXSID10869029 Css NA 0.07187 mg/L 3compartmentss NA 95% Rat Human +DTXSID10869029 Css NA 0.01052 mg/L PBTK NA 50% Rat Human +DTXSID10869029 Css NA 0.05128 mg/L PBTK NA 95% Rat Human +DTXSID10869549 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10869549 Fup 0.82 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10869549 Vd NA 3.547 L/kg 1compartment NA NA Human Human +DTXSID10869549 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10869549 TK.Half.Life NA 6.849 hours 1compartment NA NA Human Human +DTXSID10869549 Css NA 0.1149 mg/L 3compartmentss NA 50% Human Human +DTXSID10869549 Css NA 0.8703 mg/L 3compartmentss NA 95% Human Human +DTXSID10869549 Css NA 0.117 mg/L PBTK NA 50% Human Human +DTXSID10869549 Css NA 0.7339 mg/L PBTK NA 95% Human Human +DTXSID10869549 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10869549 Fup 0.82 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10869549 Vd NA 3.113 L/kg 1compartment NA NA Rat Human +DTXSID10869549 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10869549 TK.Half.Life NA 2.173 hours 1compartment NA NA Rat Human +DTXSID10869549 Css NA 0.005067 mg/L 3compartmentss NA 50% Rat Human +DTXSID10869549 Css NA 0.04271 mg/L 3compartmentss NA 95% Rat Human +DTXSID10869549 Css NA 0.005298 mg/L PBTK NA 50% Rat Human +DTXSID10869549 Css NA 0.03538 mg/L PBTK NA 95% Rat Human +DTXSID10869988 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10869988 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10869988 Vd NA 1.005 L/kg 1compartment NA NA Human Human +DTXSID10869988 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10869988 TK.Half.Life NA 10.47 hours 1compartment NA NA Human Human +DTXSID10869988 Css NA 1.608 mg/L 3compartmentss NA 50% Human Human +DTXSID10869988 Css NA 10.65 mg/L 3compartmentss NA 95% Human Human +DTXSID10869988 Css NA 1.016 mg/L PBTK NA 50% Human Human +DTXSID10869988 Css NA 6.477 mg/L PBTK NA 95% Human Human +DTXSID10869988 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10869988 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10869988 Vd NA 0.7748 L/kg 1compartment NA NA Rat Human +DTXSID10869988 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10869988 TK.Half.Life NA 4.575 hours 1compartment NA NA Rat Human +DTXSID10869988 Css NA 0.1962 mg/L 3compartmentss NA 50% Rat Human +DTXSID10869988 Css NA 1.021 mg/L 3compartmentss NA 95% Rat Human +DTXSID10869988 Css NA 0.12 mg/L PBTK NA 50% Rat Human +DTXSID10869988 Css NA 0.5953 mg/L PBTK NA 95% Rat Human +DTXSID10870170 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10870170 Fup 0.0894 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10870170 Vd NA 1.207 L/kg 1compartment NA NA Human Human +DTXSID10870170 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10870170 TK.Half.Life NA 3.522 hours 1compartment NA NA Human Human +DTXSID10870170 Css NA 0.3052 mg/L 3compartmentss NA 50% Human Human +DTXSID10870170 Css NA 2.387 mg/L 3compartmentss NA 95% Human Human +DTXSID10870170 Css NA 0.1958 mg/L PBTK NA 50% Human Human +DTXSID10870170 Css NA 1.489 mg/L PBTK NA 95% Human Human +DTXSID10870170 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10870170 Fup 0.0894 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10870170 Vd NA 0.9312 L/kg 1compartment NA NA Rat Human +DTXSID10870170 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10870170 TK.Half.Life NA 1.467 hours 1compartment NA NA Rat Human +DTXSID10870170 Css NA 0.02046 mg/L 3compartmentss NA 50% Rat Human +DTXSID10870170 Css NA 0.1497 mg/L 3compartmentss NA 95% Rat Human +DTXSID10870170 Css NA 0.01295 mg/L PBTK NA 50% Rat Human +DTXSID10870170 Css NA 0.08859 mg/L PBTK NA 95% Rat Human +DTXSID10870312 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10870312 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10870312 Vd NA 0.5292 L/kg 1compartment NA NA Human Human +DTXSID10870312 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10870312 TK.Half.Life NA 1.682 hours 1compartment NA NA Human Human +DTXSID10870312 Css NA 0.2766 mg/L 3compartmentss NA 50% Human Human +DTXSID10870312 Css NA 1.63 mg/L 3compartmentss NA 95% Human Human +DTXSID10870312 Css NA 0.1883 mg/L PBTK NA 50% Human Human +DTXSID10870312 Css NA 1.05 mg/L PBTK NA 95% Human Human +DTXSID10870312 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10870312 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10870312 Vd NA 0.4812 L/kg 1compartment NA NA Rat Human +DTXSID10870312 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10870312 TK.Half.Life NA 0.8831 hours 1compartment NA NA Rat Human +DTXSID10870312 Css NA 0.01317 mg/L 3compartmentss NA 50% Rat Human +DTXSID10870312 Css NA 0.08407 mg/L 3compartmentss NA 95% Rat Human +DTXSID10870312 Css NA 0.0088 mg/L PBTK NA 50% Rat Human +DTXSID10870312 Css NA 0.05269 mg/L PBTK NA 95% Rat Human +DTXSID10870938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10870938 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10870938 Vd NA 1.582 L/kg 1compartment NA NA Human Human +DTXSID10870938 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10870938 TK.Half.Life NA 4.292 hours 1compartment NA NA Human Human +DTXSID10870938 Css NA 0.2816 mg/L 3compartmentss NA 50% Human Human +DTXSID10870938 Css NA 2.108 mg/L 3compartmentss NA 95% Human Human +DTXSID10870938 Css NA 0.1881 mg/L PBTK NA 50% Human Human +DTXSID10870938 Css NA 1.344 mg/L PBTK NA 95% Human Human +DTXSID10870938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10870938 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10870938 Vd NA 1.212 L/kg 1compartment NA NA Rat Human +DTXSID10870938 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10870938 TK.Half.Life NA 1.629 hours 1compartment NA NA Rat Human +DTXSID10870938 Css NA 0.03661 mg/L 3compartmentss NA 50% Rat Human +DTXSID10870938 Css NA 0.215 mg/L 3compartmentss NA 95% Rat Human +DTXSID10870938 Css NA 0.02404 mg/L PBTK NA 50% Rat Human +DTXSID10870938 Css NA 0.1332 mg/L PBTK NA 95% Rat Human +DTXSID10873202 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10873202 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10873202 Vd NA 0.2839 L/kg 1compartment NA NA Human Human +DTXSID10873202 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID10873202 TK.Half.Life NA 14.96 hours 1compartment NA NA Human Human +DTXSID10873202 Css NA 9.917 mg/L 3compartmentss NA 50% Human Human +DTXSID10873202 Css NA 83.65 mg/L 3compartmentss NA 95% Human Human +DTXSID10873202 Css NA 5.804 mg/L PBTK NA 50% Human Human +DTXSID10873202 Css NA 48.92 mg/L PBTK NA 95% Human Human +DTXSID10873202 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10873202 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10873202 Vd NA 0.2441 L/kg 1compartment NA NA Rat Human +DTXSID10873202 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10873202 TK.Half.Life NA 8.708 hours 1compartment NA NA Rat Human +DTXSID10873202 Css NA 1.316 mg/L 3compartmentss NA 50% Rat Human +DTXSID10873202 Css NA 8.191 mg/L 3compartmentss NA 95% Rat Human +DTXSID10873202 Css NA 0.741 mg/L PBTK NA 50% Rat Human +DTXSID10873202 Css NA 4.587 mg/L PBTK NA 95% Rat Human +DTXSID10873222 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10873222 Fup 0.415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10873222 Vd NA 0.4724 L/kg 1compartment NA NA Human Human +DTXSID10873222 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10873222 TK.Half.Life NA 7.365 hours 1compartment NA NA Human Human +DTXSID10873222 Css NA 0.9386 mg/L 3compartmentss NA 50% Human Human +DTXSID10873222 Css NA 4.497 mg/L 3compartmentss NA 95% Human Human +DTXSID10873222 Css NA 0.693 mg/L PBTK NA 50% Human Human +DTXSID10873222 Css NA 2.848 mg/L PBTK NA 95% Human Human +DTXSID10873222 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10873222 Fup 0.415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10873222 Vd NA 0.4791 L/kg 1compartment NA NA Rat Human +DTXSID10873222 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10873222 TK.Half.Life NA 2.545 hours 1compartment NA NA Rat Human +DTXSID10873222 Css NA 0.005108 mg/L 3compartmentss NA 50% Rat Human +DTXSID10873222 Css NA 0.02415 mg/L 3compartmentss NA 95% Rat Human +DTXSID10873222 Css NA 0.003587 mg/L PBTK NA 50% Rat Human +DTXSID10873222 Css NA 0.01477 mg/L PBTK NA 95% Rat Human +DTXSID10873363 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10873363 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10873363 Vd NA 5.628 L/kg 1compartment NA NA Human Human +DTXSID10873363 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10873363 TK.Half.Life NA 8.572 hours 1compartment NA NA Human Human +DTXSID10873363 Css NA 0.06329 mg/L 3compartmentss NA 50% Human Human +DTXSID10873363 Css NA 0.5987 mg/L 3compartmentss NA 95% Human Human +DTXSID10873363 Css NA 0.1089 mg/L PBTK NA 50% Human Human +DTXSID10873363 Css NA 0.6767 mg/L PBTK NA 95% Human Human +DTXSID10873363 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10873363 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10873363 Vd NA 5.134 L/kg 1compartment NA NA Rat Human +DTXSID10873363 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10873363 TK.Half.Life NA 5.373 hours 1compartment NA NA Rat Human +DTXSID10873363 Css NA 0.008885 mg/L 3compartmentss NA 50% Rat Human +DTXSID10873363 Css NA 0.06105 mg/L 3compartmentss NA 95% Rat Human +DTXSID10873363 Css NA 0.01486 mg/L PBTK NA 50% Rat Human +DTXSID10873363 Css NA 0.0623 mg/L PBTK NA 95% Rat Human +DTXSID10873368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10873368 Fup 0.012 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human +DTXSID10873368 Vd NA 0.2336 L/kg 1compartment NA NA Human Human +DTXSID10873368 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID10873368 TK.Half.Life NA 10.89 hours 1compartment NA NA Human Human +DTXSID10873368 Css NA 8.574 mg/L 3compartmentss NA 50% Human Human +DTXSID10873368 Css NA 74.35 mg/L 3compartmentss NA 95% Human Human +DTXSID10873368 Css NA 5.022 mg/L PBTK NA 50% Human Human +DTXSID10873368 Css NA 42.44 mg/L PBTK NA 95% Human Human +DTXSID10873368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10873368 Fup 0.012 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human +DTXSID10873368 Vd NA 0.208 L/kg 1compartment NA NA Rat Human +DTXSID10873368 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10873368 TK.Half.Life NA 6.183 hours 1compartment NA NA Rat Human +DTXSID10873368 Css NA 1.055 mg/L 3compartmentss NA 50% Rat Human +DTXSID10873368 Css NA 7.137 mg/L 3compartmentss NA 95% Rat Human +DTXSID10873368 Css NA 0.5961 mg/L PBTK NA 50% Rat Human +DTXSID10873368 Css NA 3.998 mg/L PBTK NA 95% Rat Human +DTXSID10879360 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10879360 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10879360 Vd NA 1.859 L/kg 1compartment NA NA Human Human +DTXSID10879360 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID10879360 TK.Half.Life NA 32.42 hours 1compartment NA NA Human Human +DTXSID10879360 Css NA 1.399 mg/L 3compartmentss NA 50% Human Human +DTXSID10879360 Css NA 7.063 mg/L 3compartmentss NA 95% Human Human +DTXSID10879360 Css NA 1.351 mg/L PBTK NA 50% Human Human +DTXSID10879360 Css NA 5.086 mg/L PBTK NA 95% Human Human +DTXSID10879360 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10879360 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10879360 Vd NA 1.836 L/kg 1compartment NA NA Rat Human +DTXSID10879360 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID10879360 TK.Half.Life NA 10.91 hours 1compartment NA NA Rat Human +DTXSID10879360 Css NA 0.06731 mg/L 3compartmentss NA 50% Rat Human +DTXSID10879360 Css NA 0.3167 mg/L 3compartmentss NA 95% Rat Human +DTXSID10879360 Css NA 0.06796 mg/L PBTK NA 50% Rat Human +DTXSID10879360 Css NA 0.2249 mg/L PBTK NA 95% Rat Human +DTXSID10880638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880638 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880638 Vd NA 2.29 L/kg 1compartment NA NA Human Human +DTXSID10880638 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10880638 TK.Half.Life NA 5.645 hours 1compartment NA NA Human Human +DTXSID10880638 Css NA 0.206 mg/L 3compartmentss NA 50% Human Human +DTXSID10880638 Css NA 1.378 mg/L 3compartmentss NA 95% Human Human +DTXSID10880638 Css NA 0.1484 mg/L PBTK NA 50% Human Human +DTXSID10880638 Css NA 0.9332 mg/L PBTK NA 95% Human Human +DTXSID10880638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880638 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880638 Vd NA 1.749 L/kg 1compartment NA NA Rat Human +DTXSID10880638 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10880638 TK.Half.Life NA 1.72 hours 1compartment NA NA Rat Human +DTXSID10880638 Css NA 0.02619 mg/L 3compartmentss NA 50% Rat Human +DTXSID10880638 Css NA 0.1304 mg/L 3compartmentss NA 95% Rat Human +DTXSID10880638 Css NA 0.01872 mg/L PBTK NA 50% Rat Human +DTXSID10880638 Css NA 0.08785 mg/L PBTK NA 95% Rat Human +DTXSID10880698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880698 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880698 Vd NA 1.696 L/kg 1compartment NA NA Human Human +DTXSID10880698 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID10880698 TK.Half.Life NA 29.09 hours 1compartment NA NA Human Human +DTXSID10880698 Css NA 1.676 mg/L 3compartmentss NA 50% Human Human +DTXSID10880698 Css NA 7.694 mg/L 3compartmentss NA 95% Human Human +DTXSID10880698 Css NA 1.405 mg/L PBTK NA 50% Human Human +DTXSID10880698 Css NA 5.242 mg/L PBTK NA 95% Human Human +DTXSID10880698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880698 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880698 Vd NA 1.405 L/kg 1compartment NA NA Rat Human +DTXSID10880698 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10880698 TK.Half.Life NA 6.678 hours 1compartment NA NA Rat Human +DTXSID10880698 Css NA 0.1052 mg/L 3compartmentss NA 50% Rat Human +DTXSID10880698 Css NA 0.4427 mg/L 3compartmentss NA 95% Rat Human +DTXSID10880698 Css NA 0.08843 mg/L PBTK NA 50% Rat Human +DTXSID10880698 Css NA 0.2863 mg/L PBTK NA 95% Rat Human +DTXSID10880714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880714 Fup 0.0244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880714 Vd NA 8.656 L/kg 1compartment NA NA Human Human +DTXSID10880714 Days.Css NA 52 Days PBTK NA NA Human Human +DTXSID10880714 TK.Half.Life NA 258.2 hours 1compartment NA NA Human Human +DTXSID10880714 Css NA 2.178 mg/L 3compartmentss NA 50% Human Human +DTXSID10880714 Css NA 13.3 mg/L 3compartmentss NA 95% Human Human +DTXSID10880714 Css NA 2.358 mg/L PBTK NA 50% Human Human +DTXSID10880714 Css NA 13.88 mg/L PBTK NA 95% Human Human +DTXSID10880714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880714 Fup 0.0244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880714 Vd NA 6.769 L/kg 1compartment NA NA Rat Human +DTXSID10880714 Days.Css NA 31 Days PBTK NA NA Rat Human +DTXSID10880714 TK.Half.Life NA 35.27 hours 1compartment NA NA Rat Human +DTXSID10880714 Css NA 0.2765 mg/L 3compartmentss NA 50% Rat Human +DTXSID10880714 Css NA 1.359 mg/L 3compartmentss NA 95% Rat Human +DTXSID10880714 Css NA 0.3065 mg/L PBTK NA 50% Rat Human +DTXSID10880714 Css NA 1.508 mg/L PBTK NA 95% Rat Human +DTXSID10880759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880759 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880759 Vd NA 2.421 L/kg 1compartment NA NA Human Human +DTXSID10880759 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10880759 TK.Half.Life NA 5.074 hours 1compartment NA NA Human Human +DTXSID10880759 Css NA 0.1587 mg/L 3compartmentss NA 50% Human Human +DTXSID10880759 Css NA 1.017 mg/L 3compartmentss NA 95% Human Human +DTXSID10880759 Css NA 0.1183 mg/L PBTK NA 50% Human Human +DTXSID10880759 Css NA 0.726 mg/L PBTK NA 95% Human Human +DTXSID10880759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880759 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880759 Vd NA 1.86 L/kg 1compartment NA NA Rat Human +DTXSID10880759 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10880759 TK.Half.Life NA 1.499 hours 1compartment NA NA Rat Human +DTXSID10880759 Css NA 0.01987 mg/L 3compartmentss NA 50% Rat Human +DTXSID10880759 Css NA 0.09917 mg/L 3compartmentss NA 95% Rat Human +DTXSID10880759 Css NA 0.01474 mg/L PBTK NA 50% Rat Human +DTXSID10880759 Css NA 0.07092 mg/L PBTK NA 95% Rat Human +DTXSID10880895 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880895 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880895 Vd NA 3.691 L/kg 1compartment NA NA Human Human +DTXSID10880895 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID10880895 TK.Half.Life NA 110.1 hours 1compartment NA NA Human Human +DTXSID10880895 Css NA 1.82 mg/L 3compartmentss NA 50% Human Human +DTXSID10880895 Css NA 11.56 mg/L 3compartmentss NA 95% Human Human +DTXSID10880895 Css NA 1.324 mg/L PBTK NA 50% Human Human +DTXSID10880895 Css NA 8.252 mg/L PBTK NA 95% Human Human +DTXSID10880895 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880895 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880895 Vd NA 2.784 L/kg 1compartment NA NA Rat Human +DTXSID10880895 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID10880895 TK.Half.Life NA 14.98 hours 1compartment NA NA Rat Human +DTXSID10880895 Css NA 0.01983 mg/L 3compartmentss NA 50% Rat Human +DTXSID10880895 Css NA 0.1238 mg/L 3compartmentss NA 95% Rat Human +DTXSID10880895 Css NA 0.01395 mg/L PBTK NA 50% Rat Human +DTXSID10880895 Css NA 0.08636 mg/L PBTK NA 95% Rat Human +DTXSID10880916 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880916 Fup 0.0581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10880916 Vd NA 0.8418 L/kg 1compartment NA NA Human Human +DTXSID10880916 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10880916 TK.Half.Life NA 3.228 hours 1compartment NA NA Human Human +DTXSID10880916 Css NA 0.5087 mg/L 3compartmentss NA 50% Human Human +DTXSID10880916 Css NA 4.033 mg/L 3compartmentss NA 95% Human Human +DTXSID10880916 Css NA 0.3162 mg/L PBTK NA 50% Human Human +DTXSID10880916 Css NA 2.427 mg/L PBTK NA 95% Human Human +DTXSID10880916 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880916 Fup 0.0581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10880916 Vd NA 0.6549 L/kg 1compartment NA NA Rat Human +DTXSID10880916 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10880916 TK.Half.Life NA 1.471 hours 1compartment NA NA Rat Human +DTXSID10880916 Css NA 0.0665 mg/L 3compartmentss NA 50% Rat Human +DTXSID10880916 Css NA 0.4094 mg/L 3compartmentss NA 95% Rat Human +DTXSID10880916 Css NA 0.04022 mg/L PBTK NA 50% Rat Human +DTXSID10880916 Css NA 0.2379 mg/L PBTK NA 95% Rat Human +DTXSID10881206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10881206 Fup 0.0213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10881206 Vd NA 6.991 L/kg 1compartment NA NA Human Human +DTXSID10881206 Days.Css NA 40 Days PBTK NA NA Human Human +DTXSID10881206 TK.Half.Life NA 209.2 hours 1compartment NA NA Human Human +DTXSID10881206 Css NA 2.486 mg/L 3compartmentss NA 50% Human Human +DTXSID10881206 Css NA 14.58 mg/L 3compartmentss NA 95% Human Human +DTXSID10881206 Css NA 2.362 mg/L PBTK NA 50% Human Human +DTXSID10881206 Css NA 13.52 mg/L PBTK NA 95% Human Human +DTXSID10881206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10881206 Fup 0.0213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10881206 Vd NA 5.418 L/kg 1compartment NA NA Rat Human +DTXSID10881206 Days.Css NA 24 Days PBTK NA NA Rat Human +DTXSID10881206 TK.Half.Life NA 28.51 hours 1compartment NA NA Rat Human +DTXSID10881206 Css NA 0.3167 mg/L 3compartmentss NA 50% Rat Human +DTXSID10881206 Css NA 1.503 mg/L 3compartmentss NA 95% Rat Human +DTXSID10881206 Css NA 0.3068 mg/L PBTK NA 50% Rat Human +DTXSID10881206 Css NA 1.483 mg/L PBTK NA 95% Rat Human +DTXSID10958907 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID10958907 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID10958907 Vd NA 2.003 L/kg 1compartment NA NA Human Human +DTXSID10958907 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID10958907 TK.Half.Life NA 2.754 hours 1compartment NA NA Human Human +DTXSID10958907 Css NA 0.07748 mg/L 3compartmentss NA 50% Human Human +DTXSID10958907 Css NA 0.6891 mg/L 3compartmentss NA 95% Human Human +DTXSID10958907 Css NA 0.0716 mg/L PBTK NA 50% Human Human +DTXSID10958907 Css NA 0.5118 mg/L PBTK NA 95% Human Human +DTXSID10958907 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID10958907 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID10958907 Vd NA 1.689 L/kg 1compartment NA NA Rat Human +DTXSID10958907 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID10958907 TK.Half.Life NA 1.053 hours 1compartment NA NA Rat Human +DTXSID10958907 Css NA 0.003508 mg/L 3compartmentss NA 50% Rat Human +DTXSID10958907 Css NA 0.03138 mg/L 3compartmentss NA 95% Rat Human +DTXSID10958907 Css NA 0.003336 mg/L PBTK NA 50% Rat Human +DTXSID10958907 Css NA 0.02354 mg/L PBTK NA 95% Rat Human +DTXSID201009336 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID201009336 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID201009336 Vd NA 2.913 L/kg 1compartment NA NA Human Human +DTXSID201009336 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID201009336 TK.Half.Life NA 64.96 hours 1compartment NA NA Human Human +DTXSID201009336 Css NA 2.859 mg/L 3compartmentss NA 50% Human Human +DTXSID201009336 Css NA 19.31 mg/L 3compartmentss NA 95% Human Human +DTXSID201009336 Css NA 1.941 mg/L PBTK NA 50% Human Human +DTXSID201009336 Css NA 12.65 mg/L PBTK NA 95% Human Human +DTXSID201009336 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID201009336 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID201009336 Vd NA 2.18 L/kg 1compartment NA NA Rat Human +DTXSID201009336 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID201009336 TK.Half.Life NA 11.36 hours 1compartment NA NA Rat Human +DTXSID201009336 Css NA 0.3709 mg/L 3compartmentss NA 50% Rat Human +DTXSID201009336 Css NA 2.196 mg/L 3compartmentss NA 95% Rat Human +DTXSID201009336 Css NA 0.2489 mg/L PBTK NA 50% Rat Human +DTXSID201009336 Css NA 1.445 mg/L PBTK NA 95% Rat Human +DTXSID201009398 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID201009398 Fup 0.21 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID201009398 Vd NA 0.283 L/kg 1compartment NA NA Human Human +DTXSID201009398 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID201009398 TK.Half.Life NA 8.718 hours 1compartment NA NA Human Human +DTXSID201009398 Css NA 2.085 mg/L 3compartmentss NA 50% Human Human +DTXSID201009398 Css NA 8.241 mg/L 3compartmentss NA 95% Human Human +DTXSID201009398 Css NA 1.332 mg/L PBTK NA 50% Human Human +DTXSID201009398 Css NA 4.944 mg/L PBTK NA 95% Human Human +DTXSID201009398 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID201009398 Fup 0.21 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID201009398 Vd NA 0.2866 L/kg 1compartment NA NA Rat Human +DTXSID201009398 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID201009398 TK.Half.Life NA 3.008 hours 1compartment NA NA Rat Human +DTXSID201009398 Css NA 0.01147 mg/L 3compartmentss NA 50% Rat Human +DTXSID201009398 Css NA 0.04318 mg/L 3compartmentss NA 95% Rat Human +DTXSID201009398 Css NA 0.006936 mg/L PBTK NA 50% Rat Human +DTXSID201009398 Css NA 0.0247 mg/L PBTK NA 95% Rat Human +DTXSID201015892 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID201015892 Fup 0.603 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID201015892 Vd NA 0.5663 L/kg 1compartment NA NA Human Human +DTXSID201015892 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID201015892 TK.Half.Life NA 6.086 hours 1compartment NA NA Human Human +DTXSID201015892 Css NA 0.6936 mg/L 3compartmentss NA 50% Human Human +DTXSID201015892 Css NA 4.691 mg/L 3compartmentss NA 95% Human Human +DTXSID201015892 Css NA 0.5322 mg/L PBTK NA 50% Human Human +DTXSID201015892 Css NA 2.97 mg/L PBTK NA 95% Human Human +DTXSID201015892 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID201015892 Fup 0.603 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID201015892 Vd NA 0.5791 L/kg 1compartment NA NA Rat Human +DTXSID201015892 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID201015892 TK.Half.Life NA 2.118 hours 1compartment NA NA Rat Human +DTXSID201015892 Css NA 0.003726 mg/L 3compartmentss NA 50% Rat Human +DTXSID201015892 Css NA 0.02655 mg/L 3compartmentss NA 95% Rat Human +DTXSID201015892 Css NA 0.002724 mg/L PBTK NA 50% Rat Human +DTXSID201015892 Css NA 0.01563 mg/L PBTK NA 95% Rat Human +DTXSID201025948 Clint 62 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID201025948 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID201025948 Vd NA 0.8894 L/kg 1compartment NA NA Human Human +DTXSID201025948 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID201025948 TK.Half.Life NA 3.328 hours 1compartment NA NA Human Human +DTXSID201025948 Css NA 0.4494 mg/L 3compartmentss NA 50% Human Human +DTXSID201025948 Css NA 4.494 mg/L 3compartmentss NA 95% Human Human +DTXSID201025948 Css NA 0.272 mg/L PBTK NA 50% Human Human +DTXSID201025948 Css NA 2.659 mg/L PBTK NA 95% Human Human +DTXSID201025948 Clint 62 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID201025948 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID201025948 Vd NA 0.6645 L/kg 1compartment NA NA Rat Human +DTXSID201025948 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID201025948 TK.Half.Life NA 1.447 hours 1compartment NA NA Rat Human +DTXSID201025948 Css NA 0.02272 mg/L 3compartmentss NA 50% Rat Human +DTXSID201025948 Css NA 0.2555 mg/L 3compartmentss NA 95% Rat Human +DTXSID201025948 Css NA 0.01317 mg/L PBTK NA 50% Rat Human +DTXSID201025948 Css NA 0.146 mg/L PBTK NA 95% Rat Human +DTXSID201026091 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID201026091 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID201026091 Vd NA 0.2386 L/kg 1compartment NA NA Human Human +DTXSID201026091 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID201026091 TK.Half.Life NA 10.3 hours 1compartment NA NA Human Human +DTXSID201026091 Css NA 7.668 mg/L 3compartmentss NA 50% Human Human +DTXSID201026091 Css NA 59.85 mg/L 3compartmentss NA 95% Human Human +DTXSID201026091 Css NA 4.572 mg/L PBTK NA 50% Human Human +DTXSID201026091 Css NA 35.48 mg/L PBTK NA 95% Human Human +DTXSID201026091 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID201026091 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID201026091 Vd NA 0.2328 L/kg 1compartment NA NA Rat Human +DTXSID201026091 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID201026091 TK.Half.Life NA 6.145 hours 1compartment NA NA Rat Human +DTXSID201026091 Css NA 0.8868 mg/L 3compartmentss NA 50% Rat Human +DTXSID201026091 Css NA 5.803 mg/L 3compartmentss NA 95% Rat Human +DTXSID201026091 Css NA 0.5107 mg/L PBTK NA 50% Rat Human +DTXSID201026091 Css NA 3.266 mg/L PBTK NA 95% Rat Human +DTXSID201114062 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID201114062 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID201114062 Vd NA 1.602 L/kg 1compartment NA NA Human Human +DTXSID201114062 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID201114062 TK.Half.Life NA 5.227 hours 1compartment NA NA Human Human +DTXSID201114062 Css NA 0.277 mg/L 3compartmentss NA 50% Human Human +DTXSID201114062 Css NA 1.772 mg/L 3compartmentss NA 95% Human Human +DTXSID201114062 Css NA 0.2231 mg/L PBTK NA 50% Human Human +DTXSID201114062 Css NA 1.26 mg/L PBTK NA 95% Human Human +DTXSID201114062 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID201114062 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID201114062 Vd NA 1.57 L/kg 1compartment NA NA Rat Human +DTXSID201114062 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID201114062 TK.Half.Life NA 2.992 hours 1compartment NA NA Rat Human +DTXSID201114062 Css NA 0.03066 mg/L 3compartmentss NA 50% Rat Human +DTXSID201114062 Css NA 0.1426 mg/L 3compartmentss NA 95% Rat Human +DTXSID201114062 Css NA 0.02494 mg/L PBTK NA 50% Rat Human +DTXSID201114062 Css NA 0.09938 mg/L PBTK NA 95% Rat Human +DTXSID20150238 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20150238 Fup 0.0022 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20150238 Vd NA 1.631 L/kg 1compartment NA NA Human Human +DTXSID20150238 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID20150238 TK.Half.Life NA 57.19 hours 1compartment NA NA Human Human +DTXSID20150238 Css NA 4.999 mg/L 3compartmentss NA 50% Human Human +DTXSID20150238 Css NA 44.75 mg/L 3compartmentss NA 95% Human Human +DTXSID20150238 Css NA 3.107 mg/L PBTK NA 50% Human Human +DTXSID20150238 Css NA 27.15 mg/L PBTK NA 95% Human Human +DTXSID20150238 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20150238 Fup 0.0022 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20150238 Vd NA 1.201 L/kg 1compartment NA NA Rat Human +DTXSID20150238 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID20150238 TK.Half.Life NA 21.24 hours 1compartment NA NA Rat Human +DTXSID20150238 Css NA 0.2577 mg/L 3compartmentss NA 50% Rat Human +DTXSID20150238 Css NA 2.363 mg/L 3compartmentss NA 95% Rat Human +DTXSID20150238 Css NA 0.1538 mg/L PBTK NA 50% Rat Human +DTXSID20150238 Css NA 1.364 mg/L PBTK NA 95% Rat Human +DTXSID20152499 Clint 15 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID20152499 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20152499 Vd NA 0.2484 L/kg 1compartment NA NA Human Human +DTXSID20152499 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID20152499 TK.Half.Life NA 18.73 hours 1compartment NA NA Human Human +DTXSID20152499 Css NA 12.42 mg/L 3compartmentss NA 50% Human Human +DTXSID20152499 Css NA 101.5 mg/L 3compartmentss NA 95% Human Human +DTXSID20152499 Css NA 7.177 mg/L PBTK NA 50% Human Human +DTXSID20152499 Css NA 59.21 mg/L PBTK NA 95% Human Human +DTXSID20152499 Clint 15 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID20152499 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20152499 Vd NA 0.21 L/kg 1compartment NA NA Rat Human +DTXSID20152499 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID20152499 TK.Half.Life NA 10.62 hours 1compartment NA NA Rat Human +DTXSID20152499 Css NA 0.61 mg/L 3compartmentss NA 50% Rat Human +DTXSID20152499 Css NA 5.45 mg/L 3compartmentss NA 95% Rat Human +DTXSID20152499 Css NA 0.3372 mg/L PBTK NA 50% Rat Human +DTXSID20152499 Css NA 3.029 mg/L PBTK NA 95% Rat Human +DTXSID20155309 Clint 16.6 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20155309 Fup 0.0129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20155309 Vd NA 2.532 L/kg 1compartment NA NA Human Human +DTXSID20155309 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID20155309 TK.Half.Life NA 51.77 hours 1compartment NA NA Human Human +DTXSID20155309 Css NA 2.908 mg/L 3compartmentss NA 50% Human Human +DTXSID20155309 Css NA 21.75 mg/L 3compartmentss NA 95% Human Human +DTXSID20155309 Css NA 1.918 mg/L PBTK NA 50% Human Human +DTXSID20155309 Css NA 13.85 mg/L PBTK NA 95% Human Human +DTXSID20155309 Clint 16.6 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20155309 Fup 0.0129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20155309 Vd NA 1.887 L/kg 1compartment NA NA Rat Human +DTXSID20155309 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID20155309 TK.Half.Life NA 12.35 hours 1compartment NA NA Rat Human +DTXSID20155309 Css NA 0.3758 mg/L 3compartmentss NA 50% Rat Human +DTXSID20155309 Css NA 2.361 mg/L 3compartmentss NA 95% Rat Human +DTXSID20155309 Css NA 0.244 mg/L PBTK NA 50% Rat Human +DTXSID20155309 Css NA 1.454 mg/L PBTK NA 95% Rat Human +DTXSID20163045 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20163045 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20163045 Vd NA 1.1 L/kg 1compartment NA NA Human Human +DTXSID20163045 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20163045 TK.Half.Life NA 4.203 hours 1compartment NA NA Human Human +DTXSID20163045 Css NA 0.4332 mg/L 3compartmentss NA 50% Human Human +DTXSID20163045 Css NA 3.46 mg/L 3compartmentss NA 95% Human Human +DTXSID20163045 Css NA 0.2742 mg/L PBTK NA 50% Human Human +DTXSID20163045 Css NA 2.099 mg/L PBTK NA 95% Human Human +DTXSID20163045 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20163045 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20163045 Vd NA 0.8511 L/kg 1compartment NA NA Rat Human +DTXSID20163045 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20163045 TK.Half.Life NA 1.83 hours 1compartment NA NA Rat Human +DTXSID20163045 Css NA 0.02102 mg/L 3compartmentss NA 50% Rat Human +DTXSID20163045 Css NA 0.1869 mg/L 3compartmentss NA 95% Rat Human +DTXSID20163045 Css NA 0.01299 mg/L PBTK NA 50% Rat Human +DTXSID20163045 Css NA 0.1097 mg/L PBTK NA 95% Rat Human +DTXSID20163782 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20163782 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20163782 Vd NA 0.4347 L/kg 1compartment NA NA Human Human +DTXSID20163782 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20163782 TK.Half.Life NA 0.8481 hours 1compartment NA NA Human Human +DTXSID20163782 Css NA 0.1658 mg/L 3compartmentss NA 50% Human Human +DTXSID20163782 Css NA 1.36 mg/L 3compartmentss NA 95% Human Human +DTXSID20163782 Css NA 0.1109 mg/L PBTK NA 50% Human Human +DTXSID20163782 Css NA 0.8463 mg/L PBTK NA 95% Human Human +DTXSID20163782 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20163782 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20163782 Vd NA 0.4291 L/kg 1compartment NA NA Rat Human +DTXSID20163782 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20163782 TK.Half.Life NA 0.4807 hours 1compartment NA NA Rat Human +DTXSID20163782 Css NA 0.02122 mg/L 3compartmentss NA 50% Rat Human +DTXSID20163782 Css NA 0.1382 mg/L 3compartmentss NA 95% Rat Human +DTXSID20163782 Css NA 0.01389 mg/L PBTK NA 50% Rat Human +DTXSID20163782 Css NA 0.08439 mg/L PBTK NA 95% Rat Human +DTXSID20165786 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20165786 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20165786 Vd NA 1.539 L/kg 1compartment NA NA Human Human +DTXSID20165786 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20165786 TK.Half.Life NA 1.192 hours 1compartment NA NA Human Human +DTXSID20165786 Css NA 0.02218 mg/L 3compartmentss NA 50% Human Human +DTXSID20165786 Css NA 0.2848 mg/L 3compartmentss NA 95% Human Human +DTXSID20165786 Css NA 0.01842 mg/L PBTK NA 50% Human Human +DTXSID20165786 Css NA 0.2134 mg/L PBTK NA 95% Human Human +DTXSID20165786 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20165786 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20165786 Vd NA 1.271 L/kg 1compartment NA NA Rat Human +DTXSID20165786 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20165786 TK.Half.Life NA 0.4423 hours 1compartment NA NA Rat Human +DTXSID20165786 Css NA 0.00258 mg/L 3compartmentss NA 50% Rat Human +DTXSID20165786 Css NA 0.02629 mg/L 3compartmentss NA 95% Rat Human +DTXSID20165786 Css NA 0.002227 mg/L PBTK NA 50% Rat Human +DTXSID20165786 Css NA 0.01923 mg/L PBTK NA 95% Rat Human +DTXSID20165928 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20165928 Fup 0.751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20165928 Vd NA 0.6391 L/kg 1compartment NA NA Human Human +DTXSID20165928 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20165928 TK.Half.Life NA 5.506 hours 1compartment NA NA Human Human +DTXSID20165928 Css NA 1.042 mg/L 3compartmentss NA 50% Human Human +DTXSID20165928 Css NA 6.26 mg/L 3compartmentss NA 95% Human Human +DTXSID20165928 Css NA 0.8248 mg/L PBTK NA 50% Human Human +DTXSID20165928 Css NA 4.009 mg/L PBTK NA 95% Human Human +DTXSID20165928 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20165928 Fup 0.751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20165928 Vd NA 0.6753 L/kg 1compartment NA NA Rat Human +DTXSID20165928 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20165928 TK.Half.Life NA 1.983 hours 1compartment NA NA Rat Human +DTXSID20165928 Css NA 0.06152 mg/L 3compartmentss NA 50% Rat Human +DTXSID20165928 Css NA 0.3699 mg/L 3compartmentss NA 95% Rat Human +DTXSID20165928 Css NA 0.04896 mg/L PBTK NA 50% Rat Human +DTXSID20165928 Css NA 0.2258 mg/L PBTK NA 95% Rat Human +DTXSID20170956 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20170956 Fup 0.0085 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20170956 Vd NA 0.1703 L/kg 1compartment NA NA Human Human +DTXSID20170956 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20170956 TK.Half.Life NA 3.671 hours 1compartment NA NA Human Human +DTXSID20170956 Css NA 3.432 mg/L 3compartmentss NA 50% Human Human +DTXSID20170956 Css NA 33.91 mg/L 3compartmentss NA 95% Human Human +DTXSID20170956 Css NA 2.005 mg/L PBTK NA 50% Human Human +DTXSID20170956 Css NA 19.43 mg/L PBTK NA 95% Human Human +DTXSID20170956 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20170956 Fup 0.0085 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20170956 Vd NA 0.1679 L/kg 1compartment NA NA Rat Human +DTXSID20170956 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20170956 TK.Half.Life NA 2.429 hours 1compartment NA NA Rat Human +DTXSID20170956 Css NA 0.1737 mg/L 3compartmentss NA 50% Rat Human +DTXSID20170956 Css NA 1.858 mg/L 3compartmentss NA 95% Rat Human +DTXSID20170956 Css NA 0.09629 mg/L PBTK NA 50% Rat Human +DTXSID20170956 Css NA 1.033 mg/L PBTK NA 95% Rat Human +DTXSID20173260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20173260 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20173260 Vd NA 2.202 L/kg 1compartment NA NA Human Human +DTXSID20173260 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID20173260 TK.Half.Life NA 35.78 hours 1compartment NA NA Human Human +DTXSID20173260 Css NA 2.414 mg/L 3compartmentss NA 50% Human Human +DTXSID20173260 Css NA 19.8 mg/L 3compartmentss NA 95% Human Human +DTXSID20173260 Css NA 1.558 mg/L PBTK NA 50% Human Human +DTXSID20173260 Css NA 12.11 mg/L PBTK NA 95% Human Human +DTXSID20173260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20173260 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20173260 Vd NA 1.635 L/kg 1compartment NA NA Rat Human +DTXSID20173260 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID20173260 TK.Half.Life NA 10.42 hours 1compartment NA NA Rat Human +DTXSID20173260 Css NA 0.3144 mg/L 3compartmentss NA 50% Rat Human +DTXSID20173260 Css NA 2.148 mg/L 3compartmentss NA 95% Rat Human +DTXSID20173260 Css NA 0.1984 mg/L PBTK NA 50% Rat Human +DTXSID20173260 Css NA 1.296 mg/L PBTK NA 95% Rat Human +DTXSID20179106 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20179106 Fup 0.0166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20179106 Vd NA 3.106 L/kg 1compartment NA NA Human Human +DTXSID20179106 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID20179106 TK.Half.Life NA 87.66 hours 1compartment NA NA Human Human +DTXSID20179106 Css NA 3.378 mg/L 3compartmentss NA 50% Human Human +DTXSID20179106 Css NA 21.43 mg/L 3compartmentss NA 95% Human Human +DTXSID20179106 Css NA 2.325 mg/L PBTK NA 50% Human Human +DTXSID20179106 Css NA 14.6 mg/L PBTK NA 95% Human Human +DTXSID20179106 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20179106 Fup 0.0166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20179106 Vd NA 2.327 L/kg 1compartment NA NA Rat Human +DTXSID20179106 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID20179106 TK.Half.Life NA 12.03 hours 1compartment NA NA Rat Human +DTXSID20179106 Css NA 0.4349 mg/L 3compartmentss NA 50% Rat Human +DTXSID20179106 Css NA 2.323 mg/L 3compartmentss NA 95% Rat Human +DTXSID20179106 Css NA 0.2994 mg/L PBTK NA 50% Rat Human +DTXSID20179106 Css NA 1.588 mg/L PBTK NA 95% Rat Human +DTXSID20179702 Clint 8.91 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20179702 Fup 0.0917 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20179702 Vd NA 2.581 L/kg 1compartment NA NA Human Human +DTXSID20179702 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID20179702 TK.Half.Life NA 28.06 hours 1compartment NA NA Human Human +DTXSID20179702 Css NA 1.194 mg/L 3compartmentss NA 50% Human Human +DTXSID20179702 Css NA 7.68 mg/L 3compartmentss NA 95% Human Human +DTXSID20179702 Css NA 0.8183 mg/L PBTK NA 50% Human Human +DTXSID20179702 Css NA 5.041 mg/L PBTK NA 95% Human Human +DTXSID20179702 Clint 8.91 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20179702 Fup 0.0917 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20179702 Vd NA 1.943 L/kg 1compartment NA NA Rat Human +DTXSID20179702 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID20179702 TK.Half.Life NA 6.589 hours 1compartment NA NA Rat Human +DTXSID20179702 Css NA 0.05808 mg/L 3compartmentss NA 50% Rat Human +DTXSID20179702 Css NA 0.3685 mg/L 3compartmentss NA 95% Rat Human +DTXSID20179702 Css NA 0.03883 mg/L PBTK NA 50% Rat Human +DTXSID20179702 Css NA 0.2335 mg/L PBTK NA 95% Rat Human +DTXSID20182594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20182594 Fup 0.512 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20182594 Vd NA 0.9361 L/kg 1compartment NA NA Human Human +DTXSID20182594 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20182594 TK.Half.Life NA 0.9075 hours 1compartment NA NA Human Human +DTXSID20182594 Css NA 0.03716 mg/L 3compartmentss NA 50% Human Human +DTXSID20182594 Css NA 0.3574 mg/L 3compartmentss NA 95% Human Human +DTXSID20182594 Css NA 0.02966 mg/L PBTK NA 50% Human Human +DTXSID20182594 Css NA 0.2446 mg/L PBTK NA 95% Human Human +DTXSID20182594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20182594 Fup 0.512 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20182594 Vd NA 0.8715 L/kg 1compartment NA NA Rat Human +DTXSID20182594 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20182594 TK.Half.Life NA 0.4234 hours 1compartment NA NA Rat Human +DTXSID20182594 Css NA 0.004551 mg/L 3compartmentss NA 50% Rat Human +DTXSID20182594 Css NA 0.03527 mg/L 3compartmentss NA 95% Rat Human +DTXSID20182594 Css NA 0.003708 mg/L PBTK NA 50% Rat Human +DTXSID20182594 Css NA 0.02315 mg/L PBTK NA 95% Rat Human +DTXSID20190199 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20190199 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20190199 Vd NA 3.062 L/kg 1compartment NA NA Human Human +DTXSID20190199 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID20190199 TK.Half.Life NA 78.32 hours 1compartment NA NA Human Human +DTXSID20190199 Css NA 3.104 mg/L 3compartmentss NA 50% Human Human +DTXSID20190199 Css NA 20.48 mg/L 3compartmentss NA 95% Human Human +DTXSID20190199 Css NA 2.147 mg/L PBTK NA 50% Human Human +DTXSID20190199 Css NA 13.56 mg/L PBTK NA 95% Human Human +DTXSID20190199 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20190199 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20190199 Vd NA 2.293 L/kg 1compartment NA NA Rat Human +DTXSID20190199 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID20190199 TK.Half.Life NA 11.43 hours 1compartment NA NA Rat Human +DTXSID20190199 Css NA 0.4011 mg/L 3compartmentss NA 50% Rat Human +DTXSID20190199 Css NA 2.338 mg/L 3compartmentss NA 95% Rat Human +DTXSID20190199 Css NA 0.2738 mg/L PBTK NA 50% Rat Human +DTXSID20190199 Css NA 1.55 mg/L PBTK NA 95% Rat Human +DTXSID20191469 Clint 15.75 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20191469 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20191469 Vd NA 1.386 L/kg 1compartment NA NA Human Human +DTXSID20191469 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20191469 TK.Half.Life NA 1.977 hours 1compartment NA NA Human Human +DTXSID20191469 Css NA 0.08277 mg/L 3compartmentss NA 50% Human Human +DTXSID20191469 Css NA 0.6254 mg/L 3compartmentss NA 95% Human Human +DTXSID20191469 Css NA 0.06399 mg/L PBTK NA 50% Human Human +DTXSID20191469 Css NA 0.4432 mg/L PBTK NA 95% Human Human +DTXSID20191469 Clint 15.75 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20191469 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20191469 Vd NA 1.152 L/kg 1compartment NA NA Rat Human +DTXSID20191469 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20191469 TK.Half.Life NA 0.828 hours 1compartment NA NA Rat Human +DTXSID20191469 Css NA 0.009791 mg/L 3compartmentss NA 50% Rat Human +DTXSID20191469 Css NA 0.05418 mg/L 3compartmentss NA 95% Rat Human +DTXSID20191469 Css NA 0.007616 mg/L PBTK NA 50% Rat Human +DTXSID20191469 Css NA 0.0377 mg/L PBTK NA 95% Rat Human +DTXSID20192693 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20192693 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20192693 Vd NA 1.576 L/kg 1compartment NA NA Human Human +DTXSID20192693 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20192693 TK.Half.Life NA 4.706 hours 1compartment NA NA Human Human +DTXSID20192693 Css NA 0.3192 mg/L 3compartmentss NA 50% Human Human +DTXSID20192693 Css NA 3.188 mg/L 3compartmentss NA 95% Human Human +DTXSID20192693 Css NA 0.2514 mg/L PBTK NA 50% Human Human +DTXSID20192693 Css NA 2.177 mg/L PBTK NA 95% Human Human +DTXSID20192693 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20192693 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20192693 Vd NA 1.518 L/kg 1compartment NA NA Rat Human +DTXSID20192693 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20192693 TK.Half.Life NA 2.818 hours 1compartment NA NA Rat Human +DTXSID20192693 Css NA 0.04149 mg/L 3compartmentss NA 50% Rat Human +DTXSID20192693 Css NA 0.3297 mg/L 3compartmentss NA 95% Rat Human +DTXSID20192693 Css NA 0.03223 mg/L PBTK NA 50% Rat Human +DTXSID20192693 Css NA 0.2157 mg/L PBTK NA 95% Rat Human DTXSID2020006 Clint 0.3598 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID2020006 Fup 0.9398 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID2020006 Vd NA 1.043 L/kg 1compartment NA NA Human Human DTXSID2020006 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2020006 TK.Half.Life NA 4.655 hours 1compartment NA NA Human Human -DTXSID2020006 Css NA 0.4398 mg/L 3compartmentss NA 50% Human Human -DTXSID2020006 Css NA 1.411 mg/L 3compartmentss NA 95% Human Human -DTXSID2020006 Css NA 0.4092 mg/L PBTK NA 50% Human Human -DTXSID2020006 Css NA 1.12 mg/L PBTK NA 95% Human Human +DTXSID2020006 Css NA 0.4002 mg/L 3compartmentss NA 50% Human Human +DTXSID2020006 Css NA 1.044 mg/L 3compartmentss NA 95% Human Human +DTXSID2020006 Css NA 0.399 mg/L PBTK NA 50% Human Human +DTXSID2020006 Css NA 1.042 mg/L PBTK NA 95% Human Human DTXSID2020006 Clint 15.83 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID2020006 Fup 0.82 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat DTXSID2020006 Vd NA 0.944 L/kg 1compartment NA NA Rat Rat DTXSID2020006 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID2020006 TK.Half.Life NA 0.3681 hours 1compartment NA NA Rat Rat -DTXSID2020006 Css NA 0.01742 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2020006 Css NA 0.1497 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2020006 Css NA 0.0157 mg/L PBTK NA 50% Rat Rat -DTXSID2020006 Css NA 0.1038 mg/L PBTK NA 95% Rat Rat -DTXSID2020054 Clint NA 13.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020054 Fup NA 0.0597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020054 Vd NA 1.771 L/kg 1compartment NA NA Human Human +DTXSID2020006 Css NA 0.003412 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2020006 Css NA 0.02336 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2020006 Css NA 0.003538 mg/L PBTK NA 50% Rat Rat +DTXSID2020006 Css NA 0.02419 mg/L PBTK NA 95% Rat Rat +DTXSID2020054 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020054 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020054 Vd NA 1.427 L/kg 1compartment NA NA Human Human DTXSID2020054 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020054 TK.Half.Life NA 11.7 hours 1compartment NA NA Human Human -DTXSID2020054 Css NA 0.9288 mg/L 3compartmentss NA 50% Human Human -DTXSID2020054 Css NA 6.266 mg/L 3compartmentss NA 95% Human Human -DTXSID2020054 Css NA 0.6053 mg/L PBTK NA 50% Human Human -DTXSID2020054 Css NA 3.858 mg/L PBTK NA 95% Human Human -DTXSID2020054 Clint NA 13.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020054 Fup NA 0.0597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020054 Vd NA 1.333 L/kg 1compartment NA NA Rat Human +DTXSID2020054 TK.Half.Life NA 1.684 hours 1compartment NA NA Human Human +DTXSID2020054 Css NA 0.05636 mg/L 3compartmentss NA 50% Human Human +DTXSID2020054 Css NA 0.4413 mg/L 3compartmentss NA 95% Human Human +DTXSID2020054 Css NA 0.04444 mg/L PBTK NA 50% Human Human +DTXSID2020054 Css NA 0.3109 mg/L PBTK NA 95% Human Human +DTXSID2020054 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020054 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020054 Vd NA 1.185 L/kg 1compartment NA NA Rat Human DTXSID2020054 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020054 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human -DTXSID2020054 Css NA 0.5117 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020054 Css NA 2.724 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020054 Css NA 0.315 mg/L PBTK NA 50% Rat Human -DTXSID2020054 Css NA 1.606 mg/L PBTK NA 95% Rat Human -DTXSID2020131 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020131 Fup NA 0.2371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020131 Vd NA 0.3109 L/kg 1compartment NA NA Human Human -DTXSID2020131 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020131 TK.Half.Life NA 8.484 hours 1compartment NA NA Human Human -DTXSID2020131 Css NA 3.433 mg/L 3compartmentss NA 50% Human Human -DTXSID2020131 Css NA 12.83 mg/L 3compartmentss NA 95% Human Human -DTXSID2020131 Css NA 2.234 mg/L PBTK NA 50% Human Human -DTXSID2020131 Css NA 7.717 mg/L PBTK NA 95% Human Human -DTXSID2020131 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020131 Fup NA 0.2371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020131 Vd NA 0.3326 L/kg 1compartment NA NA Rat Human -DTXSID2020131 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020131 TK.Half.Life NA 3.093 hours 1compartment NA NA Rat Human -DTXSID2020131 Css NA 0.9545 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020131 Css NA 2.889 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020131 Css NA 0.5867 mg/L PBTK NA 50% Rat Human -DTXSID2020131 Css NA 1.638 mg/L PBTK NA 95% Rat Human +DTXSID2020054 TK.Half.Life NA 0.6856 hours 1compartment NA NA Rat Human +DTXSID2020054 Css NA 0.006936 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020054 Css NA 0.04215 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020054 Css NA 0.00549 mg/L PBTK NA 50% Rat Human +DTXSID2020054 Css NA 0.02937 mg/L PBTK NA 95% Rat Human DTXSID2020137 Clint 6.91 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID2020137 Fup 0.1977 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID2020137 Vd NA 0.6608 L/kg 1compartment NA NA Human Human DTXSID2020137 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2020137 TK.Half.Life NA 2.202 hours 1compartment NA NA Human Human -DTXSID2020137 Css NA 0.331 mg/L 3compartmentss NA 50% Human Human -DTXSID2020137 Css NA 1.961 mg/L 3compartmentss NA 95% Human Human -DTXSID2020137 Css NA 0.2276 mg/L PBTK NA 50% Human Human -DTXSID2020137 Css NA 1.24 mg/L PBTK NA 95% Human Human +DTXSID2020137 Css NA 0.3256 mg/L 3compartmentss NA 50% Human Human +DTXSID2020137 Css NA 1.95 mg/L 3compartmentss NA 95% Human Human +DTXSID2020137 Css NA 0.2219 mg/L PBTK NA 50% Human Human +DTXSID2020137 Css NA 1.243 mg/L PBTK NA 95% Human Human DTXSID2020137 Clint 6.91 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID2020137 Fup 0.1977 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID2020137 Vd NA 0.5868 L/kg 1compartment NA NA Rat Human DTXSID2020137 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2020137 TK.Half.Life NA 1.133 hours 1compartment NA NA Rat Human -DTXSID2020137 Css NA 0.1746 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020137 Css NA 0.7542 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020137 Css NA 0.1134 mg/L PBTK NA 50% Rat Human -DTXSID2020137 Css NA 0.4543 mg/L PBTK NA 95% Rat Human +DTXSID2020137 Css NA 0.03942 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020137 Css NA 0.1704 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020137 Css NA 0.0266 mg/L PBTK NA 50% Rat Human +DTXSID2020137 Css NA 0.1055 mg/L PBTK NA 95% Rat Human DTXSID2020139 Clint 3.713 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID2020139 Fup 0.3826 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID2020139 Vd NA 3.834 L/kg 1compartment NA NA Human Human -DTXSID2020139 Days.Css NA 157 Days PBTK NA NA Human Human -DTXSID2020139 TK.Half.Life NA 654.5 hours 1compartment NA NA Human Human -DTXSID2020139 Css NA 19.06 mg/L 3compartmentss NA 50% Human Human -DTXSID2020139 Css NA 105.3 mg/L 3compartmentss NA 95% Human Human -DTXSID2020139 Css NA 14.06 mg/L PBTK NA 50% Human Human -DTXSID2020139 Css NA 77.25 mg/L PBTK NA 95% Human Human +DTXSID2020139 Vd NA 5.338 L/kg 1compartment NA NA Human Human +DTXSID2020139 Days.Css NA 225 Days PBTK NA NA Human Human +DTXSID2020139 TK.Half.Life NA 910.7 hours 1compartment NA NA Human Human +DTXSID2020139 Css NA 16.23 mg/L 3compartmentss NA 50% Human Human +DTXSID2020139 Css NA 97.23 mg/L 3compartmentss NA 95% Human Human +DTXSID2020139 Css NA 13.62 mg/L PBTK NA 50% Human Human +DTXSID2020139 Css NA 79.13 mg/L PBTK NA 95% Human Human DTXSID2020139 Clint 21.98 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID2020139 Fup 0.03758 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat -DTXSID2020139 Vd NA 2.889 L/kg 1compartment NA NA Rat Rat -DTXSID2020139 Days.Css NA 11 Days PBTK NA NA Rat Rat -DTXSID2020139 TK.Half.Life NA 15.22 hours 1compartment NA NA Rat Rat -DTXSID2020139 Css NA 1.826 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2020139 Css NA 8.134 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2020139 Css NA 1.292 mg/L PBTK NA 50% Rat Rat -DTXSID2020139 Css NA 5.788 mg/L PBTK NA 95% Rat Rat -DTXSID2020181 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020181 Fup NA 0.8664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020181 Vd NA 1.046 L/kg 1compartment NA NA Human Human -DTXSID2020181 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020181 TK.Half.Life NA 8.002 hours 1compartment NA NA Human Human -DTXSID2020181 Css NA 0.897 mg/L 3compartmentss NA 50% Human Human -DTXSID2020181 Css NA 5.298 mg/L 3compartmentss NA 95% Human Human -DTXSID2020181 Css NA 0.7922 mg/L PBTK NA 50% Human Human -DTXSID2020181 Css NA 3.56 mg/L PBTK NA 95% Human Human -DTXSID2020181 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020181 Fup NA 0.8664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020181 Vd NA 1.019 L/kg 1compartment NA NA Rat Human -DTXSID2020181 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020181 TK.Half.Life NA 2.608 hours 1compartment NA NA Rat Human -DTXSID2020181 Css NA 0.2282 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020181 Css NA 1.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020181 Css NA 0.1964 mg/L PBTK NA 50% Rat Human -DTXSID2020181 Css NA 0.8367 mg/L PBTK NA 95% Rat Human +DTXSID2020139 Vd 62 4.08 L/kg 1compartment Schlede et al. (1970), Wiersma et al. (1983), Marie et al. (2010), Moir et al. (1998) NA Rat Rat +DTXSID2020139 Days.Css NA 17 Days PBTK NA NA Rat Rat +DTXSID2020139 TK.Half.Life 36 21.36 hours 1compartment Schlede et al. (1970), Wiersma et al. (1983), Marie et al. (2010), Moir et al. (1998) NA Rat Rat +DTXSID2020139 Css 0.035 0.3584 mg/L 3compartmentss Schlede et al. (1970), Wiersma et al. (1983), Marie et al. (2010), Moir et al. (1998) 50% Rat Rat +DTXSID2020139 Css 0.035 1.772 mg/L 3compartmentss Schlede et al. (1970), Wiersma et al. (1983), Marie et al. (2010), Moir et al. (1998) 95% Rat Rat +DTXSID2020139 Css 0.035 0.3012 mg/L PBTK Schlede et al. (1970), Wiersma et al. (1983), Marie et al. (2010), Moir et al. (1998) 50% Rat Rat +DTXSID2020139 Css 0.035 1.535 mg/L PBTK Schlede et al. (1970), Wiersma et al. (1983), Marie et al. (2010), Moir et al. (1998) 95% Rat Rat DTXSID2020189 Clint NA 8.436 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2020189 Fup NA 0.0234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020189 Vd NA 0.4726 L/kg 1compartment NA NA Human Human +DTXSID2020189 Vd NA 0.18 L/kg 1compartment NA NA Human Human DTXSID2020189 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020189 TK.Half.Life NA 8.724 hours 1compartment NA NA Human Human -DTXSID2020189 Css NA 3.09 mg/L 3compartmentss NA 50% Human Human -DTXSID2020189 Css NA 28.31 mg/L 3compartmentss NA 95% Human Human -DTXSID2020189 Css NA 1.952 mg/L PBTK NA 50% Human Human -DTXSID2020189 Css NA 16.95 mg/L PBTK NA 95% Human Human +DTXSID2020189 TK.Half.Life NA 1.069 hours 1compartment NA NA Human Human +DTXSID2020189 Css NA 0.7989 mg/L 3compartmentss NA 50% Human Human +DTXSID2020189 Css NA 8.625 mg/L 3compartmentss NA 95% Human Human +DTXSID2020189 Css NA 0.4672 mg/L PBTK NA 50% Human Human +DTXSID2020189 Css NA 4.955 mg/L PBTK NA 95% Human Human DTXSID2020189 Clint NA 8.436 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2020189 Fup NA 0.0234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020189 Vd NA 0.4299 L/kg 1compartment NA NA Rat Human +DTXSID2020189 Vd NA 0.1811 L/kg 1compartment NA NA Rat Human DTXSID2020189 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020189 TK.Half.Life NA 5.085 hours 1compartment NA NA Rat Human -DTXSID2020189 Css NA 1.709 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020189 Css NA 12.53 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020189 Css NA 1.01 mg/L PBTK NA 50% Rat Human -DTXSID2020189 Css NA 6.912 mg/L PBTK NA 95% Rat Human -DTXSID2020210 Clint NA 2.705 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020210 Fup NA 0.614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020210 Vd NA 1.046 L/kg 1compartment NA NA Human Human -DTXSID2020210 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020210 TK.Half.Life NA 2.514 hours 1compartment NA NA Human Human -DTXSID2020210 Css NA 0.224 mg/L 3compartmentss NA 50% Human Human -DTXSID2020210 Css NA 1.799 mg/L 3compartmentss NA 95% Human Human -DTXSID2020210 Css NA 0.189 mg/L PBTK NA 50% Human Human -DTXSID2020210 Css NA 1.21 mg/L PBTK NA 95% Human Human -DTXSID2020210 Clint NA 2.705 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020210 Fup NA 0.614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020210 Vd NA 0.9721 L/kg 1compartment NA NA Rat Human +DTXSID2020189 TK.Half.Life NA 0.6954 hours 1compartment NA NA Rat Human +DTXSID2020189 Css NA 0.0308 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020189 Css NA 0.3756 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020189 Css NA 0.01711 mg/L PBTK NA 50% Rat Human +DTXSID2020189 Css NA 0.2088 mg/L PBTK NA 95% Rat Human +DTXSID2020210 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020210 Fup 0.617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020210 Vd NA 0.9957 L/kg 1compartment NA NA Human Human +DTXSID2020210 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2020210 TK.Half.Life NA 10.85 hours 1compartment NA NA Human Human +DTXSID2020210 Css NA 1.134 mg/L 3compartmentss NA 50% Human Human +DTXSID2020210 Css NA 8.109 mg/L 3compartmentss NA 95% Human Human +DTXSID2020210 Css NA 0.9562 mg/L PBTK NA 50% Human Human +DTXSID2020210 Css NA 5.098 mg/L PBTK NA 95% Human Human +DTXSID2020210 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020210 Fup 0.617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020210 Vd NA 0.9355 L/kg 1compartment NA NA Rat Human DTXSID2020210 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020210 TK.Half.Life NA 1.223 hours 1compartment NA NA Rat Human -DTXSID2020210 Css NA 0.09931 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020210 Css NA 0.7548 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020210 Css NA 0.08184 mg/L PBTK NA 50% Rat Human -DTXSID2020210 Css NA 0.4586 mg/L PBTK NA 95% Rat Human +DTXSID2020210 TK.Half.Life NA 3.373 hours 1compartment NA NA Rat Human +DTXSID2020210 Css NA 0.06913 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020210 Css NA 0.4577 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020210 Css NA 0.0583 mg/L PBTK NA 50% Rat Human +DTXSID2020210 Css NA 0.2829 mg/L PBTK NA 95% Rat Human DTXSID2020212 Clint 20.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2020212 Fup 0.0272 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2020212 Vd NA 1.634 L/kg 1compartment NA NA Human Human +DTXSID2020212 Vd NA 2.171 L/kg 1compartment NA NA Human Human DTXSID2020212 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2020212 TK.Half.Life NA 12.74 hours 1compartment NA NA Human Human -DTXSID2020212 Css NA 0.9317 mg/L 3compartmentss NA 50% Human Human -DTXSID2020212 Css NA 6.532 mg/L 3compartmentss NA 95% Human Human -DTXSID2020212 Css NA 0.6011 mg/L PBTK NA 50% Human Human -DTXSID2020212 Css NA 4.099 mg/L PBTK NA 95% Human Human +DTXSID2020212 TK.Half.Life NA 19.83 hours 1compartment NA NA Human Human +DTXSID2020212 Css NA 1.067 mg/L 3compartmentss NA 50% Human Human +DTXSID2020212 Css NA 7.298 mg/L 3compartmentss NA 95% Human Human +DTXSID2020212 Css NA 0.7086 mg/L PBTK NA 50% Human Human +DTXSID2020212 Css NA 4.634 mg/L PBTK NA 95% Human Human DTXSID2020212 Clint 20.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2020212 Fup 0.0272 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2020212 Vd NA 1.216 L/kg 1compartment NA NA Rat Human -DTXSID2020212 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020212 TK.Half.Life NA 4.709 hours 1compartment NA NA Rat Human -DTXSID2020212 Css NA 0.518 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020212 Css NA 2.757 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020212 Css NA 0.3153 mg/L PBTK NA 50% Rat Human -DTXSID2020212 Css NA 1.621 mg/L PBTK NA 95% Rat Human -DTXSID2020216 Clint NA 4.364 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020216 Fup NA 0.0212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020216 Vd NA 3.04 L/kg 1compartment NA NA Human Human -DTXSID2020216 Days.Css NA 69 Days PBTK NA NA Human Human -DTXSID2020216 TK.Half.Life NA 314.8 hours 1compartment NA NA Human Human -DTXSID2020216 Css NA 13.36 mg/L 3compartmentss NA 50% Human Human -DTXSID2020216 Css NA 81.13 mg/L 3compartmentss NA 95% Human Human -DTXSID2020216 Css NA 9.175 mg/L PBTK NA 50% Human Human -DTXSID2020216 Css NA 53.58 mg/L PBTK NA 95% Human Human -DTXSID2020216 Clint NA 4.364 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020216 Fup NA 0.0212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020216 Vd NA 2.276 L/kg 1compartment NA NA Rat Human -DTXSID2020216 Days.Css NA 37 Days PBTK NA NA Rat Human -DTXSID2020216 TK.Half.Life NA 45.24 hours 1compartment NA NA Rat Human -DTXSID2020216 Css NA 7.433 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020216 Css NA 35.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020216 Css NA 4.884 mg/L PBTK NA 50% Rat Human -DTXSID2020216 Css NA 22.48 mg/L PBTK NA 95% Rat Human -DTXSID2020260 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020260 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020260 Vd NA 0.32 L/kg 1compartment NA NA Human Human -DTXSID2020260 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID2020260 TK.Half.Life NA 42.89 hours 1compartment NA NA Human Human -DTXSID2020260 Css NA 22.1 mg/L 3compartmentss NA 50% Human Human -DTXSID2020260 Css NA 111.1 mg/L 3compartmentss NA 95% Human Human -DTXSID2020260 Css NA 13.38 mg/L PBTK NA 50% Human Human -DTXSID2020260 Css NA 65.23 mg/L PBTK NA 95% Human Human -DTXSID2020260 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020260 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020260 Vd NA 0.2881 L/kg 1compartment NA NA Rat Human -DTXSID2020260 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2020260 TK.Half.Life NA 13.1 hours 1compartment NA NA Rat Human -DTXSID2020260 Css NA 6.258 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020260 Css NA 26.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020260 Css NA 3.545 mg/L PBTK NA 50% Rat Human -DTXSID2020260 Css NA 14.29 mg/L PBTK NA 95% Rat Human +DTXSID2020212 Vd NA 1.618 L/kg 1compartment NA NA Rat Human +DTXSID2020212 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2020212 TK.Half.Life NA 5.919 hours 1compartment NA NA Rat Human +DTXSID2020212 Css NA 0.1389 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020212 Css NA 0.7228 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020212 Css NA 0.09061 mg/L PBTK NA 50% Rat Human +DTXSID2020212 Css NA 0.4532 mg/L PBTK NA 95% Rat Human +DTXSID2020260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020260 Fup 0.0447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020260 Vd NA 0.3099 L/kg 1compartment NA NA Human Human +DTXSID2020260 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2020260 TK.Half.Life NA 1.465 hours 1compartment NA NA Human Human +DTXSID2020260 Css NA 0.6906 mg/L 3compartmentss NA 50% Human Human +DTXSID2020260 Css NA 5.697 mg/L 3compartmentss NA 95% Human Human +DTXSID2020260 Css NA 0.4154 mg/L PBTK NA 50% Human Human +DTXSID2020260 Css NA 3.366 mg/L PBTK NA 95% Human Human +DTXSID2020260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020260 Fup 0.0447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020260 Vd NA 0.2794 L/kg 1compartment NA NA Rat Human +DTXSID2020260 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2020260 TK.Half.Life NA 0.8326 hours 1compartment NA NA Rat Human +DTXSID2020260 Css NA 0.09045 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020260 Css NA 0.5811 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020260 Css NA 0.05288 mg/L PBTK NA 50% Rat Human +DTXSID2020260 Css NA 0.3327 mg/L PBTK NA 95% Rat Human DTXSID2020262 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2020262 Fup NA 0.0523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020262 Vd NA 0.2351 L/kg 1compartment NA NA Human Human -DTXSID2020262 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2020262 TK.Half.Life NA 29.09 hours 1compartment NA NA Human Human -DTXSID2020262 Css NA 20.67 mg/L 3compartmentss NA 50% Human Human -DTXSID2020262 Css NA 97.92 mg/L 3compartmentss NA 95% Human Human -DTXSID2020262 Css NA 12.46 mg/L PBTK NA 50% Human Human -DTXSID2020262 Css NA 57.28 mg/L PBTK NA 95% Human Human +DTXSID2020262 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020262 Vd NA 0.4803 L/kg 1compartment NA NA Human Human +DTXSID2020262 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2020262 TK.Half.Life NA 11.42 hours 1compartment NA NA Human Human +DTXSID2020262 Css NA 2.666 mg/L 3compartmentss NA 50% Human Human +DTXSID2020262 Css NA 10.3 mg/L 3compartmentss NA 95% Human Human +DTXSID2020262 Css NA 1.889 mg/L PBTK NA 50% Human Human +DTXSID2020262 Css NA 6.488 mg/L PBTK NA 95% Human Human DTXSID2020262 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2020262 Fup NA 0.0523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020262 Vd NA 0.2345 L/kg 1compartment NA NA Rat Human -DTXSID2020262 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2020262 TK.Half.Life NA 9.887 hours 1compartment NA NA Rat Human -DTXSID2020262 Css NA 5.862 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020262 Css NA 23.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020262 Css NA 3.281 mg/L PBTK NA 50% Rat Human -DTXSID2020262 Css NA 12.91 mg/L PBTK NA 95% Rat Human -DTXSID2020268 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020268 Fup NA 0.0273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020268 Vd NA 0.2674 L/kg 1compartment NA NA Human Human -DTXSID2020268 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID2020268 TK.Half.Life NA 63.42 hours 1compartment NA NA Human Human -DTXSID2020268 Css NA 40.18 mg/L 3compartmentss NA 50% Human Human -DTXSID2020268 Css NA 239 mg/L 3compartmentss NA 95% Human Human -DTXSID2020268 Css NA 24.16 mg/L PBTK NA 50% Human Human -DTXSID2020268 Css NA 139.6 mg/L PBTK NA 95% Human Human -DTXSID2020268 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020268 Fup NA 0.0273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020268 Vd NA 0.2598 L/kg 1compartment NA NA Rat Human -DTXSID2020268 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2020268 TK.Half.Life NA 20.98 hours 1compartment NA NA Rat Human -DTXSID2020268 Css NA 11.43 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020268 Css NA 59.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020268 Css NA 6.424 mg/L PBTK NA 50% Rat Human -DTXSID2020268 Css NA 32.62 mg/L PBTK NA 95% Rat Human +DTXSID2020262 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020262 Vd NA 0.4843 L/kg 1compartment NA NA Rat Human +DTXSID2020262 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2020262 TK.Half.Life NA 3.925 hours 1compartment NA NA Rat Human +DTXSID2020262 Css NA 0.1722 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020262 Css NA 0.5569 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020262 Css NA 0.1197 mg/L PBTK NA 50% Rat Human +DTXSID2020262 Css NA 0.3383 mg/L PBTK NA 95% Rat Human +DTXSID2020266 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2020266 Fup NA 0.2328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2020266 Vd NA 1.542 L/kg 1compartment NA NA Human Human +DTXSID2020266 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID2020266 TK.Half.Life NA 57.38 hours 1compartment NA NA Human Human +DTXSID2020266 Css NA 4.036 mg/L 3compartmentss NA 50% Human Human +DTXSID2020266 Css NA 14.28 mg/L 3compartmentss NA 95% Human Human +DTXSID2020266 Css NA 2.952 mg/L PBTK NA 50% Human Human +DTXSID2020266 Css NA 9.241 mg/L PBTK NA 95% Human Human +DTXSID2020266 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2020266 Fup NA 0.2328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2020266 Vd NA 1.223 L/kg 1compartment NA NA Rat Human +DTXSID2020266 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2020266 TK.Half.Life NA 12.52 hours 1compartment NA NA Rat Human +DTXSID2020266 Css NA 0.2552 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020266 Css NA 0.7587 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020266 Css NA 0.1859 mg/L PBTK NA 50% Rat Human +DTXSID2020266 Css NA 0.4739 mg/L PBTK NA 95% Rat Human +DTXSID2020268 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020268 Fup 0.092 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020268 Vd NA 0.4027 L/kg 1compartment NA NA Human Human +DTXSID2020268 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2020268 TK.Half.Life NA 28.34 hours 1compartment NA NA Human Human +DTXSID2020268 Css NA 9.046 mg/L 3compartmentss NA 50% Human Human +DTXSID2020268 Css NA 44.06 mg/L 3compartmentss NA 95% Human Human +DTXSID2020268 Css NA 5.82 mg/L PBTK NA 50% Human Human +DTXSID2020268 Css NA 26.54 mg/L PBTK NA 95% Human Human +DTXSID2020268 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020268 Fup 0.092 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020268 Vd NA 0.3948 L/kg 1compartment NA NA Rat Human +DTXSID2020268 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2020268 TK.Half.Life NA 9.463 hours 1compartment NA NA Rat Human +DTXSID2020268 Css NA 0.2192 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020268 Css NA 1.402 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020268 Css NA 0.1381 mg/L PBTK NA 50% Rat Human +DTXSID2020268 Css NA 0.8109 mg/L PBTK NA 95% Rat Human +DTXSID20202746 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20202746 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20202746 Vd NA 1.604 L/kg 1compartment NA NA Human Human +DTXSID20202746 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20202746 TK.Half.Life NA 3.616 hours 1compartment NA NA Human Human +DTXSID20202746 Css NA 0.1796 mg/L 3compartmentss NA 50% Human Human +DTXSID20202746 Css NA 1.151 mg/L 3compartmentss NA 95% Human Human +DTXSID20202746 Css NA 0.1438 mg/L PBTK NA 50% Human Human +DTXSID20202746 Css NA 0.8268 mg/L PBTK NA 95% Human Human +DTXSID20202746 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20202746 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20202746 Vd NA 1.321 L/kg 1compartment NA NA Rat Human +DTXSID20202746 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20202746 TK.Half.Life NA 1.461 hours 1compartment NA NA Rat Human +DTXSID20202746 Css NA 0.01997 mg/L 3compartmentss NA 50% Rat Human +DTXSID20202746 Css NA 0.09797 mg/L 3compartmentss NA 95% Rat Human +DTXSID20202746 Css NA 0.01612 mg/L PBTK NA 50% Rat Human +DTXSID20202746 Css NA 0.06735 mg/L PBTK NA 95% Rat Human +DTXSID20202988 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20202988 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20202988 Vd NA 0.8922 L/kg 1compartment NA NA Human Human +DTXSID20202988 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20202988 TK.Half.Life NA 1.103 hours 1compartment NA NA Human Human +DTXSID20202988 Css NA 0.05988 mg/L 3compartmentss NA 50% Human Human +DTXSID20202988 Css NA 0.479 mg/L 3compartmentss NA 95% Human Human +DTXSID20202988 Css NA 0.04448 mg/L PBTK NA 50% Human Human +DTXSID20202988 Css NA 0.3226 mg/L PBTK NA 95% Human Human +DTXSID20202988 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20202988 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20202988 Vd NA 0.7911 L/kg 1compartment NA NA Rat Human +DTXSID20202988 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20202988 TK.Half.Life NA 0.5074 hours 1compartment NA NA Rat Human +DTXSID20202988 Css NA 0.007547 mg/L 3compartmentss NA 50% Rat Human +DTXSID20202988 Css NA 0.04416 mg/L 3compartmentss NA 95% Rat Human +DTXSID20202988 Css NA 0.005596 mg/L PBTK NA 50% Rat Human +DTXSID20202988 Css NA 0.02898 mg/L PBTK NA 95% Rat Human DTXSID2020341 Clint 24.53 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2020341 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID2020341 Vd NA 3.771 L/kg 1compartment NA NA Human Human DTXSID2020341 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2020341 TK.Half.Life NA 1.842 hours 1compartment NA NA Human Human -DTXSID2020341 Css NA 0.01404 mg/L 3compartmentss NA 50% Human Human -DTXSID2020341 Css NA 0.2083 mg/L 3compartmentss NA 95% Human Human -DTXSID2020341 Css NA 0.01763 mg/L PBTK NA 50% Human Human -DTXSID2020341 Css NA 0.2001 mg/L PBTK NA 95% Human Human +DTXSID2020341 Css NA 0.01231 mg/L 3compartmentss NA 50% Human Human +DTXSID2020341 Css NA 0.1758 mg/L 3compartmentss NA 95% Human Human +DTXSID2020341 Css NA 0.01556 mg/L PBTK NA 50% Human Human +DTXSID2020341 Css NA 0.1666 mg/L PBTK NA 95% Human Human DTXSID2020341 Clint 24.53 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2020341 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID2020341 Vd NA 3.846 L/kg 1compartment NA NA Rat Human DTXSID2020341 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2020341 TK.Half.Life NA 0.9301 hours 1compartment NA NA Rat Human -DTXSID2020341 Css NA 0.006778 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020341 Css NA 0.0831 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020341 Css NA 0.008868 mg/L PBTK NA 50% Rat Human -DTXSID2020341 Css NA 0.07667 mg/L PBTK NA 95% Rat Human -DTXSID2020345 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020345 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020345 Vd NA 0.4732 L/kg 1compartment NA NA Human Human +DTXSID2020341 Css NA 0.001421 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020341 Css NA 0.01724 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020341 Css NA 0.00192 mg/L PBTK NA 50% Rat Human +DTXSID2020341 Css NA 0.0166 mg/L PBTK NA 95% Rat Human +DTXSID2020345 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020345 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020345 Vd NA 0.4154 L/kg 1compartment NA NA Human Human DTXSID2020345 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020345 TK.Half.Life NA 5.986 hours 1compartment NA NA Human Human -DTXSID2020345 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human -DTXSID2020345 Css NA 7.282 mg/L 3compartmentss NA 95% Human Human -DTXSID2020345 Css NA 1.074 mg/L PBTK NA 50% Human Human -DTXSID2020345 Css NA 4.538 mg/L PBTK NA 95% Human Human -DTXSID2020345 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020345 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020345 Vd NA 0.4747 L/kg 1compartment NA NA Rat Human +DTXSID2020345 TK.Half.Life NA 5.419 hours 1compartment NA NA Human Human +DTXSID2020345 Css NA 1.311 mg/L 3compartmentss NA 50% Human Human +DTXSID2020345 Css NA 6.539 mg/L 3compartmentss NA 95% Human Human +DTXSID2020345 Css NA 0.9396 mg/L PBTK NA 50% Human Human +DTXSID2020345 Css NA 4.017 mg/L PBTK NA 95% Human Human +DTXSID2020345 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020345 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020345 Vd NA 0.4265 L/kg 1compartment NA NA Rat Human DTXSID2020345 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020345 TK.Half.Life NA 2.095 hours 1compartment NA NA Rat Human -DTXSID2020345 Css NA 0.4147 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020345 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020345 Css NA 0.285 mg/L PBTK NA 50% Rat Human -DTXSID2020345 Css NA 1.07 mg/L PBTK NA 95% Rat Human +DTXSID2020345 TK.Half.Life NA 1.896 hours 1compartment NA NA Rat Human +DTXSID2020345 Css NA 0.02496 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020345 Css NA 0.1685 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020345 Css NA 0.01722 mg/L PBTK NA 50% Rat Human +DTXSID2020345 Css NA 0.1043 mg/L PBTK NA 95% Rat Human DTXSID2020347 Clint 31.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2020347 Fup 2.9e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2020347 Vd NA 0.2759 L/kg 1compartment NA NA Human Human DTXSID2020347 Days.Css NA 32 Days PBTK NA NA Human Human DTXSID2020347 TK.Half.Life NA 141.7 hours 1compartment NA NA Human Human -DTXSID2020347 Css NA 1.343 mg/L 3compartmentss NA 50% Human Human -DTXSID2020347 Css NA 15.92 mg/L 3compartmentss NA 95% Human Human -DTXSID2020347 Css NA 0.8785 mg/L PBTK NA 50% Human Human -DTXSID2020347 Css NA 9.84 mg/L PBTK NA 95% Human Human +DTXSID2020347 Css NA 1.305 mg/L 3compartmentss NA 50% Human Human +DTXSID2020347 Css NA 15.44 mg/L 3compartmentss NA 95% Human Human +DTXSID2020347 Css NA 0.8522 mg/L PBTK NA 50% Human Human +DTXSID2020347 Css NA 9.403 mg/L PBTK NA 95% Human Human DTXSID2020347 Clint 31.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2020347 Fup 2.9e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2020347 Vd NA 0.2229 L/kg 1compartment NA NA Rat Human DTXSID2020347 Days.Css NA 16 Days PBTK NA NA Rat Human DTXSID2020347 TK.Half.Life NA 79.68 hours 1compartment NA NA Rat Human -DTXSID2020347 Css NA 0.7508 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020347 Css NA 7.803 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020347 Css NA 0.4634 mg/L PBTK NA 50% Rat Human -DTXSID2020347 Css NA 4.458 mg/L PBTK NA 95% Rat Human -DTXSID2020349 Clint NA 62.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020349 Fup NA 0.5327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020349 Vd NA 1.088 L/kg 1compartment NA NA Human Human +DTXSID2020347 Css NA 0.1674 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020347 Css NA 1.756 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020347 Css NA 0.1069 mg/L PBTK NA 50% Rat Human +DTXSID2020347 Css NA 1.045 mg/L PBTK NA 95% Rat Human +DTXSID2020349 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020349 Fup 0.373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020349 Vd NA 0.8847 L/kg 1compartment NA NA Human Human DTXSID2020349 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020349 TK.Half.Life NA 0.8122 hours 1compartment NA NA Human Human -DTXSID2020349 Css NA 0.01379 mg/L 3compartmentss NA 50% Human Human -DTXSID2020349 Css NA 0.1339 mg/L 3compartmentss NA 95% Human Human -DTXSID2020349 Css NA 0.01134 mg/L PBTK NA 50% Human Human -DTXSID2020349 Css NA 0.09465 mg/L PBTK NA 95% Human Human -DTXSID2020349 Clint NA 62.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020349 Fup NA 0.5327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020349 Vd NA 0.9886 L/kg 1compartment NA NA Rat Human +DTXSID2020349 TK.Half.Life NA 1.02 hours 1compartment NA NA Human Human +DTXSID2020349 Css NA 0.05196 mg/L 3compartmentss NA 50% Human Human +DTXSID2020349 Css NA 0.4142 mg/L 3compartmentss NA 95% Human Human +DTXSID2020349 Css NA 0.03926 mg/L PBTK NA 50% Human Human +DTXSID2020349 Css NA 0.2848 mg/L PBTK NA 95% Human Human +DTXSID2020349 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020349 Fup 0.373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020349 Vd NA 0.8016 L/kg 1compartment NA NA Rat Human DTXSID2020349 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020349 TK.Half.Life NA 0.3411 hours 1compartment NA NA Rat Human -DTXSID2020349 Css NA 0.007244 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020349 Css NA 0.0653 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020349 Css NA 0.005812 mg/L PBTK NA 50% Rat Human -DTXSID2020349 Css NA 0.04317 mg/L PBTK NA 95% Rat Human -DTXSID2020391 Clint NA 17.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020391 Fup NA 0.0789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020391 Vd NA 3.041 L/kg 1compartment NA NA Human Human -DTXSID2020391 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID2020391 TK.Half.Life NA 49.69 hours 1compartment NA NA Human Human -DTXSID2020391 Css NA 1.983 mg/L 3compartmentss NA 50% Human Human -DTXSID2020391 Css NA 12.05 mg/L 3compartmentss NA 95% Human Human -DTXSID2020391 Css NA 1.384 mg/L PBTK NA 50% Human Human -DTXSID2020391 Css NA 8.209 mg/L PBTK NA 95% Human Human -DTXSID2020391 Clint NA 17.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020391 Fup NA 0.0789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020391 Vd NA 2.281 L/kg 1compartment NA NA Rat Human -DTXSID2020391 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2020391 TK.Half.Life NA 7.653 hours 1compartment NA NA Rat Human -DTXSID2020391 Css NA 1.11 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020391 Css NA 5.643 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020391 Css NA 0.7387 mg/L PBTK NA 50% Rat Human -DTXSID2020391 Css NA 3.645 mg/L PBTK NA 95% Rat Human -DTXSID2020399 Clint NA 19.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020399 Fup NA 0.1141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020399 Vd NA 1.201 L/kg 1compartment NA NA Human Human +DTXSID2020349 TK.Half.Life NA 0.4754 hours 1compartment NA NA Rat Human +DTXSID2020349 Css NA 0.00648 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020349 Css NA 0.0384 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020349 Css NA 0.004942 mg/L PBTK NA 50% Rat Human +DTXSID2020349 Css NA 0.02614 mg/L PBTK NA 95% Rat Human +DTXSID2020391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020391 Fup 0.0424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020391 Vd NA 2.953 L/kg 1compartment NA NA Human Human +DTXSID2020391 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2020391 TK.Half.Life NA 40.09 hours 1compartment NA NA Human Human +DTXSID2020391 Css NA 1.658 mg/L 3compartmentss NA 50% Human Human +DTXSID2020391 Css NA 10.66 mg/L 3compartmentss NA 95% Human Human +DTXSID2020391 Css NA 1.142 mg/L PBTK NA 50% Human Human +DTXSID2020391 Css NA 7.059 mg/L PBTK NA 95% Human Human +DTXSID2020391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020391 Fup 0.0424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020391 Vd NA 2.212 L/kg 1compartment NA NA Rat Human +DTXSID2020391 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2020391 TK.Half.Life NA 6.876 hours 1compartment NA NA Rat Human +DTXSID2020391 Css NA 0.2154 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020391 Css NA 1.194 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020391 Css NA 0.1461 mg/L PBTK NA 50% Rat Human +DTXSID2020391 Css NA 0.7854 mg/L PBTK NA 95% Rat Human +DTXSID2020399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020399 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020399 Vd NA 1.125 L/kg 1compartment NA NA Human Human DTXSID2020399 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020399 TK.Half.Life NA 3.158 hours 1compartment NA NA Human Human -DTXSID2020399 Css NA 0.2906 mg/L 3compartmentss NA 50% Human Human -DTXSID2020399 Css NA 2.201 mg/L 3compartmentss NA 95% Human Human -DTXSID2020399 Css NA 0.192 mg/L PBTK NA 50% Human Human -DTXSID2020399 Css NA 1.362 mg/L PBTK NA 95% Human Human -DTXSID2020399 Clint NA 19.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020399 Fup NA 0.1141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020399 Vd NA 0.9378 L/kg 1compartment NA NA Rat Human +DTXSID2020399 TK.Half.Life NA 3.79 hours 1compartment NA NA Human Human +DTXSID2020399 Css NA 0.4023 mg/L 3compartmentss NA 50% Human Human +DTXSID2020399 Css NA 3.091 mg/L 3compartmentss NA 95% Human Human +DTXSID2020399 Css NA 0.2584 mg/L PBTK NA 50% Human Human +DTXSID2020399 Css NA 1.871 mg/L PBTK NA 95% Human Human +DTXSID2020399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020399 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020399 Vd NA 0.8641 L/kg 1compartment NA NA Rat Human DTXSID2020399 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020399 TK.Half.Life NA 1.325 hours 1compartment NA NA Rat Human -DTXSID2020399 Css NA 0.1588 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020399 Css NA 0.9217 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020399 Css NA 0.09904 mg/L PBTK NA 50% Rat Human -DTXSID2020399 Css NA 0.5394 mg/L PBTK NA 95% Rat Human +DTXSID2020399 TK.Half.Life NA 1.61 hours 1compartment NA NA Rat Human +DTXSID2020399 Css NA 0.05301 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020399 Css NA 0.3152 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020399 Css NA 0.03305 mg/L PBTK NA 50% Rat Human +DTXSID2020399 Css NA 0.1901 mg/L PBTK NA 95% Rat Human DTXSID2020420 Clint 5.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2020420 Fup 0.06756 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2020420 Vd NA 2.233 L/kg 1compartment NA NA Human Human DTXSID2020420 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID2020420 TK.Half.Life NA 36.01 hours 1compartment NA NA Human Human -DTXSID2020420 Css NA 2.256 mg/L 3compartmentss NA 50% Human Human -DTXSID2020420 Css NA 12.53 mg/L 3compartmentss NA 95% Human Human -DTXSID2020420 Css NA 1.507 mg/L PBTK NA 50% Human Human -DTXSID2020420 Css NA 8.081 mg/L PBTK NA 95% Human Human +DTXSID2020420 Css NA 1.824 mg/L 3compartmentss NA 50% Human Human +DTXSID2020420 Css NA 10.05 mg/L 3compartmentss NA 95% Human Human +DTXSID2020420 Css NA 1.45 mg/L PBTK NA 50% Human Human +DTXSID2020420 Css NA 7.985 mg/L PBTK NA 95% Human Human DTXSID2020420 Clint 1.71 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID2020420 Fup 0.09361 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID2020420 Vd NA 1.828 L/kg 1compartment NA NA Rat Rat +DTXSID2020420 Vd 1.9 1.828 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID2020420 Days.Css NA 7 Days PBTK NA NA Rat Rat -DTXSID2020420 TK.Half.Life NA 20.56 hours 1compartment NA NA Rat Rat -DTXSID2020420 Css NA 2.547 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2020420 Css NA 8.076 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2020420 Css NA 1.575 mg/L PBTK NA 50% Rat Rat -DTXSID2020420 Css NA 4.678 mg/L PBTK NA 95% Rat Rat -DTXSID2020424 Clint NA 12.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020424 Fup NA 0.0796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020424 Vd NA 2.412 L/kg 1compartment NA NA Human Human -DTXSID2020424 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2020424 TK.Half.Life NA 18.3 hours 1compartment NA NA Human Human -DTXSID2020424 Css NA 0.981 mg/L 3compartmentss NA 50% Human Human -DTXSID2020424 Css NA 6.167 mg/L 3compartmentss NA 95% Human Human -DTXSID2020424 Css NA 0.6699 mg/L PBTK NA 50% Human Human -DTXSID2020424 Css NA 4.053 mg/L PBTK NA 95% Human Human -DTXSID2020424 Clint NA 12.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020424 Fup NA 0.0796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020424 Vd NA 1.813 L/kg 1compartment NA NA Rat Human +DTXSID2020420 TK.Half.Life 0.11 20.56 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID2020420 Css 0.0033 0.4483 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID2020420 Css 0.0033 1.321 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID2020420 Css 0.0033 0.369 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID2020420 Css 0.0033 1.086 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID2020424 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020424 Fup 0.0412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020424 Vd NA 1.991 L/kg 1compartment NA NA Human Human +DTXSID2020424 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2020424 TK.Half.Life NA 12.38 hours 1compartment NA NA Human Human +DTXSID2020424 Css NA 0.8573 mg/L 3compartmentss NA 50% Human Human +DTXSID2020424 Css NA 6.838 mg/L 3compartmentss NA 95% Human Human +DTXSID2020424 Css NA 0.5552 mg/L PBTK NA 50% Human Human +DTXSID2020424 Css NA 4.215 mg/L PBTK NA 95% Human Human +DTXSID2020424 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020424 Fup 0.0412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020424 Vd NA 1.488 L/kg 1compartment NA NA Rat Human DTXSID2020424 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020424 TK.Half.Life NA 4.851 hours 1compartment NA NA Rat Human -DTXSID2020424 Css NA 0.5394 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020424 Css NA 2.551 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020424 Css NA 0.3481 mg/L PBTK NA 50% Rat Human -DTXSID2020424 Css NA 1.601 mg/L PBTK NA 95% Rat Human +DTXSID2020424 TK.Half.Life NA 4.03 hours 1compartment NA NA Rat Human +DTXSID2020424 Css NA 0.1112 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020424 Css NA 0.7087 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020424 Css NA 0.0708 mg/L PBTK NA 50% Rat Human +DTXSID2020424 Css NA 0.4311 mg/L PBTK NA 95% Rat Human DTXSID2020426 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID2020426 Fup NA 0.1725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020426 Vd NA 2.001 L/kg 1compartment NA NA Human Human -DTXSID2020426 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID2020426 TK.Half.Life NA 134.7 hours 1compartment NA NA Human Human -DTXSID2020426 Css NA 7.676 mg/L 3compartmentss NA 50% Human Human -DTXSID2020426 Css NA 24.33 mg/L 3compartmentss NA 95% Human Human -DTXSID2020426 Css NA 5.518 mg/L PBTK NA 50% Human Human -DTXSID2020426 Css NA 15.86 mg/L PBTK NA 95% Human Human +DTXSID2020426 Fup 0.0234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020426 Vd NA 0.7994 L/kg 1compartment NA NA Human Human +DTXSID2020426 Days.Css NA 58 Days PBTK NA NA Human Human +DTXSID2020426 TK.Half.Life NA 244.8 hours 1compartment NA NA Human Human +DTXSID2020426 Css NA 49.02 mg/L 3compartmentss NA 50% Human Human +DTXSID2020426 Css NA 285.1 mg/L 3compartmentss NA 95% Human Human +DTXSID2020426 Css NA 29.74 mg/L PBTK NA 50% Human Human +DTXSID2020426 Css NA 164.6 mg/L PBTK NA 95% Human Human DTXSID2020426 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID2020426 Fup NA 0.1725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020426 Vd NA 1.537 L/kg 1compartment NA NA Rat Human -DTXSID2020426 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID2020426 TK.Half.Life NA 23.37 hours 1compartment NA NA Rat Human -DTXSID2020426 Css NA 2.082 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020426 Css NA 5.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020426 Css NA 1.428 mg/L PBTK NA 50% Rat Human -DTXSID2020426 Css NA 3.278 mg/L PBTK NA 95% Rat Human +DTXSID2020426 Fup 0.0234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020426 Vd NA 0.6037 L/kg 1compartment NA NA Rat Human +DTXSID2020426 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID2020426 TK.Half.Life NA 58.35 hours 1compartment NA NA Rat Human +DTXSID2020426 Css NA 3.208 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020426 Css NA 16.07 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020426 Css NA 1.881 mg/L PBTK NA 50% Rat Human +DTXSID2020426 Css NA 9.077 mg/L PBTK NA 95% Rat Human DTXSID2020428 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2020428 Fup NA 0.4683 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2020428 Vd NA 0.6447 L/kg 1compartment NA NA Human Human DTXSID2020428 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2020428 TK.Half.Life NA 8.907 hours 1compartment NA NA Human Human -DTXSID2020428 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human -DTXSID2020428 Css NA 7.163 mg/L 3compartmentss NA 95% Human Human -DTXSID2020428 Css NA 1.171 mg/L PBTK NA 50% Human Human -DTXSID2020428 Css NA 4.664 mg/L PBTK NA 95% Human Human +DTXSID2020428 Css NA 1.232 mg/L 3compartmentss NA 50% Human Human +DTXSID2020428 Css NA 6.365 mg/L 3compartmentss NA 95% Human Human +DTXSID2020428 Css NA 0.974 mg/L PBTK NA 50% Human Human +DTXSID2020428 Css NA 4.093 mg/L PBTK NA 95% Human Human DTXSID2020428 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2020428 Fup NA 0.4683 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020428 Vd NA 0.6555 L/kg 1compartment NA NA Rat Human +DTXSID2020428 Vd 0.75 0.6555 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID2020428 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020428 TK.Half.Life NA 3.086 hours 1compartment NA NA Rat Human -DTXSID2020428 Css NA 0.4014 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020428 Css NA 1.695 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020428 Css NA 0.3036 mg/L PBTK NA 50% Rat Human -DTXSID2020428 Css NA 1.024 mg/L PBTK NA 95% Rat Human -DTXSID2020470 Clint NA 187.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020470 Fup NA 0.3618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020470 Vd NA 1.191 L/kg 1compartment NA NA Human Human +DTXSID2020428 TK.Half.Life 0.22 3.086 hours 1compartment National Toxicology Program NA Rat Human +DTXSID2020428 Css 0.017 0.02309 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID2020428 Css 0.017 0.1593 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID2020428 Css 0.017 0.0176 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID2020428 Css 0.017 0.1044 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID2020470 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020470 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020470 Vd NA 1.215 L/kg 1compartment NA NA Human Human DTXSID2020470 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020470 TK.Half.Life NA 0.9027 hours 1compartment NA NA Human Human -DTXSID2020470 Css NA 0.00707 mg/L 3compartmentss NA 50% Human Human -DTXSID2020470 Css NA 0.05683 mg/L 3compartmentss NA 95% Human Human -DTXSID2020470 Css NA 0.005492 mg/L PBTK NA 50% Human Human -DTXSID2020470 Css NA 0.04021 mg/L PBTK NA 95% Human Human -DTXSID2020470 Clint NA 187.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020470 Fup NA 0.3618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020470 Vd NA 1.012 L/kg 1compartment NA NA Rat Human +DTXSID2020470 TK.Half.Life NA 2.779 hours 1compartment NA NA Human Human +DTXSID2020470 Css NA 0.1876 mg/L 3compartmentss NA 50% Human Human +DTXSID2020470 Css NA 1.175 mg/L 3compartmentss NA 95% Human Human +DTXSID2020470 Css NA 0.1451 mg/L PBTK NA 50% Human Human +DTXSID2020470 Css NA 0.8101 mg/L PBTK NA 95% Human Human +DTXSID2020470 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020470 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020470 Vd NA 1.03 L/kg 1compartment NA NA Rat Human DTXSID2020470 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020470 TK.Half.Life NA 0.3426 hours 1compartment NA NA Rat Human -DTXSID2020470 Css NA 0.003906 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020470 Css NA 0.02571 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020470 Css NA 0.002903 mg/L PBTK NA 50% Rat Human -DTXSID2020470 Css NA 0.01707 mg/L PBTK NA 95% Rat Human -DTXSID2020474 Clint NA 5.554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020474 Fup NA 0.4599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020474 Vd NA 1.078 L/kg 1compartment NA NA Human Human +DTXSID2020470 TK.Half.Life NA 1.245 hours 1compartment NA NA Rat Human +DTXSID2020470 Css NA 0.02141 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020470 Css NA 0.1013 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020470 Css NA 0.0167 mg/L PBTK NA 50% Rat Human +DTXSID2020470 Css NA 0.06746 mg/L PBTK NA 95% Rat Human +DTXSID2020474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020474 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020474 Vd NA 1.082 L/kg 1compartment NA NA Human Human DTXSID2020474 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020474 TK.Half.Life NA 2.149 hours 1compartment NA NA Human Human -DTXSID2020474 Css NA 0.1606 mg/L 3compartmentss NA 50% Human Human -DTXSID2020474 Css NA 1.097 mg/L 3compartmentss NA 95% Human Human -DTXSID2020474 Css NA 0.1287 mg/L PBTK NA 50% Human Human -DTXSID2020474 Css NA 0.7606 mg/L PBTK NA 95% Human Human -DTXSID2020474 Clint NA 5.554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020474 Fup NA 0.4599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020474 Vd NA 0.9585 L/kg 1compartment NA NA Rat Human +DTXSID2020474 TK.Half.Life NA 1.567 hours 1compartment NA NA Human Human +DTXSID2020474 Css NA 0.08441 mg/L 3compartmentss NA 50% Human Human +DTXSID2020474 Css NA 0.6046 mg/L 3compartmentss NA 95% Human Human +DTXSID2020474 Css NA 0.06128 mg/L PBTK NA 50% Human Human +DTXSID2020474 Css NA 0.4085 mg/L PBTK NA 95% Human Human +DTXSID2020474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020474 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020474 Vd NA 0.9028 L/kg 1compartment NA NA Rat Human DTXSID2020474 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020474 TK.Half.Life NA 1.023 hours 1compartment NA NA Rat Human -DTXSID2020474 Css NA 0.07849 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020474 Css NA 0.4282 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020474 Css NA 0.06102 mg/L PBTK NA 50% Rat Human -DTXSID2020474 Css NA 0.2725 mg/L PBTK NA 95% Rat Human -DTXSID2020478 Clint NA 0.001497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020478 Fup NA 0.6987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020478 Vd NA 0.4331 L/kg 1compartment NA NA Human Human +DTXSID2020474 TK.Half.Life NA 0.6802 hours 1compartment NA NA Rat Human +DTXSID2020474 Css NA 0.01055 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020474 Css NA 0.05719 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020474 Css NA 0.007624 mg/L PBTK NA 50% Rat Human +DTXSID2020474 Css NA 0.03847 mg/L PBTK NA 95% Rat Human +DTXSID2020478 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020478 Fup 0.889 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020478 Vd NA 0.4911 L/kg 1compartment NA NA Human Human DTXSID2020478 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020478 TK.Half.Life NA 4 hours 1compartment NA NA Human Human -DTXSID2020478 Css NA 1.228 mg/L 3compartmentss NA 50% Human Human -DTXSID2020478 Css NA 7.273 mg/L 3compartmentss NA 95% Human Human -DTXSID2020478 Css NA 0.8876 mg/L PBTK NA 50% Human Human -DTXSID2020478 Css NA 4.448 mg/L PBTK NA 95% Human Human -DTXSID2020478 Clint NA 0.001497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020478 Fup NA 0.6987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020478 Vd NA 0.4514 L/kg 1compartment NA NA Rat Human +DTXSID2020478 TK.Half.Life NA 3.575 hours 1compartment NA NA Human Human +DTXSID2020478 Css NA 0.8804 mg/L 3compartmentss NA 50% Human Human +DTXSID2020478 Css NA 4.64 mg/L 3compartmentss NA 95% Human Human +DTXSID2020478 Css NA 0.6557 mg/L PBTK NA 50% Human Human +DTXSID2020478 Css NA 2.879 mg/L PBTK NA 95% Human Human +DTXSID2020478 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020478 Fup 0.889 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020478 Vd NA 0.513 L/kg 1compartment NA NA Rat Human DTXSID2020478 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020478 TK.Half.Life NA 1.423 hours 1compartment NA NA Rat Human -DTXSID2020478 Css NA 0.3166 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020478 Css NA 1.897 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020478 Css NA 0.2196 mg/L PBTK NA 50% Rat Human -DTXSID2020478 Css NA 1.084 mg/L PBTK NA 95% Rat Human -DTXSID2020501 Clint NA 4.838 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020501 Fup NA 0.1198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020501 Vd NA 2.956 L/kg 1compartment NA NA Human Human -DTXSID2020501 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID2020501 TK.Half.Life NA 71.87 hours 1compartment NA NA Human Human -DTXSID2020501 Css NA 3.019 mg/L 3compartmentss NA 50% Human Human -DTXSID2020501 Css NA 15.42 mg/L 3compartmentss NA 95% Human Human -DTXSID2020501 Css NA 2.135 mg/L PBTK NA 50% Human Human -DTXSID2020501 Css NA 10.62 mg/L PBTK NA 95% Human Human -DTXSID2020501 Clint NA 4.838 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020501 Fup NA 0.1198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020501 Vd NA 2.251 L/kg 1compartment NA NA Rat Human -DTXSID2020501 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID2020501 TK.Half.Life NA 12.74 hours 1compartment NA NA Rat Human -DTXSID2020501 Css NA 1.584 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020501 Css NA 6.028 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020501 Css NA 1.073 mg/L PBTK NA 50% Rat Human -DTXSID2020501 Css NA 3.927 mg/L PBTK NA 95% Rat Human +DTXSID2020478 TK.Half.Life NA 1.272 hours 1compartment NA NA Rat Human +DTXSID2020478 Css NA 0.01648 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020478 Css NA 0.1146 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020478 Css NA 0.01184 mg/L PBTK NA 50% Rat Human +DTXSID2020478 Css NA 0.07086 mg/L PBTK NA 95% Rat Human +DTXSID2020501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020501 Fup 0.0709 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020501 Vd NA 2.895 L/kg 1compartment NA NA Human Human +DTXSID2020501 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2020501 TK.Half.Life NA 23.78 hours 1compartment NA NA Human Human +DTXSID2020501 Css NA 0.928 mg/L 3compartmentss NA 50% Human Human +DTXSID2020501 Css NA 5.922 mg/L 3compartmentss NA 95% Human Human +DTXSID2020501 Css NA 0.6457 mg/L PBTK NA 50% Human Human +DTXSID2020501 Css NA 3.968 mg/L PBTK NA 95% Human Human +DTXSID2020501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020501 Fup 0.0709 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020501 Vd NA 2.193 L/kg 1compartment NA NA Rat Human +DTXSID2020501 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2020501 TK.Half.Life NA 4.764 hours 1compartment NA NA Rat Human +DTXSID2020501 Css NA 0.12 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020501 Css NA 0.6249 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020501 Css NA 0.08284 mg/L PBTK NA 50% Rat Human +DTXSID2020501 Css NA 0.4281 mg/L PBTK NA 95% Rat Human DTXSID2020505 Clint NA 0.3685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2020505 Fup NA 0.8028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020505 Vd NA 2.038 L/kg 1compartment NA NA Human Human +DTXSID2020505 Vd NA 1.794 L/kg 1compartment NA NA Human Human DTXSID2020505 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020505 TK.Half.Life NA 10.34 hours 1compartment NA NA Human Human -DTXSID2020505 Css NA 0.4898 mg/L 3compartmentss NA 50% Human Human -DTXSID2020505 Css NA 3.35 mg/L 3compartmentss NA 95% Human Human -DTXSID2020505 Css NA 0.502 mg/L PBTK NA 50% Human Human -DTXSID2020505 Css NA 2.39 mg/L PBTK NA 95% Human Human +DTXSID2020505 TK.Half.Life NA 9.11 hours 1compartment NA NA Human Human +DTXSID2020505 Css NA 0.4251 mg/L 3compartmentss NA 50% Human Human +DTXSID2020505 Css NA 2.893 mg/L 3compartmentss NA 95% Human Human +DTXSID2020505 Css NA 0.4243 mg/L PBTK NA 50% Human Human +DTXSID2020505 Css NA 2.026 mg/L PBTK NA 95% Human Human DTXSID2020505 Clint NA 0.3685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2020505 Fup NA 0.8028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020505 Vd NA 2.06 L/kg 1compartment NA NA Rat Human +DTXSID2020505 Vd NA 1.817 L/kg 1compartment NA NA Rat Human DTXSID2020505 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020505 TK.Half.Life NA 4.387 hours 1compartment NA NA Rat Human -DTXSID2020505 Css NA 0.1511 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020505 Css NA 1.119 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020505 Css NA 0.1552 mg/L PBTK NA 50% Rat Human -DTXSID2020505 Css NA 0.7231 mg/L PBTK NA 95% Rat Human -DTXSID2020507 Clint NA 23.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020507 Fup NA 0.4053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020507 Vd NA 1.994 L/kg 1compartment NA NA Human Human -DTXSID2020507 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020507 TK.Half.Life NA 2.438 hours 1compartment NA NA Human Human -DTXSID2020507 Css NA 0.0643 mg/L 3compartmentss NA 50% Human Human -DTXSID2020507 Css NA 0.4465 mg/L 3compartmentss NA 95% Human Human -DTXSID2020507 Css NA 0.05142 mg/L PBTK NA 50% Human Human -DTXSID2020507 Css NA 0.3291 mg/L PBTK NA 95% Human Human -DTXSID2020507 Clint NA 23.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020507 Fup NA 0.4053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020507 Vd NA 1.597 L/kg 1compartment NA NA Rat Human -DTXSID2020507 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020507 TK.Half.Life NA 0.8751 hours 1compartment NA NA Rat Human -DTXSID2020507 Css NA 0.03439 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020507 Css NA 0.1886 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020507 Css NA 0.0268 mg/L PBTK NA 50% Rat Human -DTXSID2020507 Css NA 0.1346 mg/L PBTK NA 95% Rat Human -DTXSID2020509 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020509 Fup NA 0.9827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020509 Vd NA 0.8211 L/kg 1compartment NA NA Human Human +DTXSID2020505 TK.Half.Life NA 3.872 hours 1compartment NA NA Rat Human +DTXSID2020505 Css NA 0.01002 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020505 Css NA 0.08777 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020505 Css NA 0.009724 mg/L PBTK NA 50% Rat Human +DTXSID2020505 Css NA 0.06322 mg/L PBTK NA 95% Rat Human +DTXSID2020509 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020509 Fup 0.794 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020509 Vd NA 0.7214 L/kg 1compartment NA NA Human Human DTXSID2020509 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020509 TK.Half.Life NA 5.419 hours 1compartment NA NA Human Human -DTXSID2020509 Css NA 0.857 mg/L 3compartmentss NA 50% Human Human -DTXSID2020509 Css NA 5.015 mg/L 3compartmentss NA 95% Human Human -DTXSID2020509 Css NA 0.727 mg/L PBTK NA 50% Human Human -DTXSID2020509 Css NA 3.304 mg/L PBTK NA 95% Human Human -DTXSID2020509 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020509 Fup NA 0.9827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020509 Vd NA 0.8467 L/kg 1compartment NA NA Rat Human +DTXSID2020509 TK.Half.Life NA 5.889 hours 1compartment NA NA Human Human +DTXSID2020509 Css NA 0.9736 mg/L 3compartmentss NA 50% Human Human +DTXSID2020509 Css NA 5.827 mg/L 3compartmentss NA 95% Human Human +DTXSID2020509 Css NA 0.7952 mg/L PBTK NA 50% Human Human +DTXSID2020509 Css NA 3.676 mg/L PBTK NA 95% Human Human +DTXSID2020509 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020509 Fup 0.794 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020509 Vd NA 0.7433 L/kg 1compartment NA NA Rat Human DTXSID2020509 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020509 TK.Half.Life NA 1.901 hours 1compartment NA NA Rat Human -DTXSID2020509 Css NA 0.2192 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020509 Css NA 1.248 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020509 Css NA 0.1804 mg/L PBTK NA 50% Rat Human -DTXSID2020509 Css NA 0.7578 mg/L PBTK NA 95% Rat Human -DTXSID2020557 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020557 Fup NA 0.0272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020557 Vd NA 0.1905 L/kg 1compartment NA NA Human Human -DTXSID2020557 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID2020557 TK.Half.Life NA 45.33 hours 1compartment NA NA Human Human -DTXSID2020557 Css NA 41.1 mg/L 3compartmentss NA 50% Human Human -DTXSID2020557 Css NA 238.9 mg/L 3compartmentss NA 95% Human Human -DTXSID2020557 Css NA 24.08 mg/L PBTK NA 50% Human Human -DTXSID2020557 Css NA 137.8 mg/L PBTK NA 95% Human Human -DTXSID2020557 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020557 Fup NA 0.0272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020557 Vd NA 0.1866 L/kg 1compartment NA NA Rat Human -DTXSID2020557 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2020557 TK.Half.Life NA 15.12 hours 1compartment NA NA Rat Human -DTXSID2020557 Css NA 11.84 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020557 Css NA 60.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020557 Css NA 6.48 mg/L PBTK NA 50% Rat Human -DTXSID2020557 Css NA 32.85 mg/L PBTK NA 95% Rat Human +DTXSID2020509 TK.Half.Life NA 2.065 hours 1compartment NA NA Rat Human +DTXSID2020509 Css NA 0.05762 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020509 Css NA 0.3439 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020509 Css NA 0.04728 mg/L PBTK NA 50% Rat Human +DTXSID2020509 Css NA 0.2124 mg/L PBTK NA 95% Rat Human +DTXSID2020557 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020557 Fup 0.0465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020557 Vd NA 0.1906 L/kg 1compartment NA NA Human Human +DTXSID2020557 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2020557 TK.Half.Life NA 26.52 hours 1compartment NA NA Human Human +DTXSID2020557 Css NA 12.79 mg/L 3compartmentss NA 50% Human Human +DTXSID2020557 Css NA 61.7 mg/L 3compartmentss NA 95% Human Human +DTXSID2020557 Css NA 7.508 mg/L PBTK NA 50% Human Human +DTXSID2020557 Css NA 35.42 mg/L PBTK NA 95% Human Human +DTXSID2020557 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020557 Fup 0.0465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020557 Vd NA 0.1904 L/kg 1compartment NA NA Rat Human +DTXSID2020557 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2020557 TK.Half.Life NA 9.027 hours 1compartment NA NA Rat Human +DTXSID2020557 Css NA 0.07084 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020557 Css NA 0.3249 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020557 Css NA 0.03917 mg/L PBTK NA 50% Rat Human +DTXSID2020557 Css NA 0.1777 mg/L PBTK NA 95% Rat Human DTXSID2020634 Clint NA 0.0103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2020634 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2020634 Vd NA 0.4984 L/kg 1compartment NA NA Human Human DTXSID2020634 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2020634 TK.Half.Life NA 4.955 hours 1compartment NA NA Human Human -DTXSID2020634 Css NA 0.7128 mg/L 3compartmentss NA 50% Human Human -DTXSID2020634 Css NA 5.94 mg/L 3compartmentss NA 95% Human Human -DTXSID2020634 Css NA 0.745 mg/L PBTK NA 50% Human Human -DTXSID2020634 Css NA 4.083 mg/L PBTK NA 95% Human Human +DTXSID2020634 Css NA 0.8133 mg/L 3compartmentss NA 50% Human Human +DTXSID2020634 Css NA 4.279 mg/L 3compartmentss NA 95% Human Human +DTXSID2020634 Css NA 0.8862 mg/L PBTK NA 50% Human Human +DTXSID2020634 Css NA 4.664 mg/L PBTK NA 95% Human Human DTXSID2020634 Clint NA 0.0103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2020634 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2020634 Vd NA 0.6708 L/kg 1compartment NA NA Rat Human DTXSID2020634 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2020634 TK.Half.Life NA 1.467 hours 1compartment NA NA Rat Human -DTXSID2020634 Css NA 0.178 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020634 Css NA 1.236 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020634 Css NA 0.1717 mg/L PBTK NA 50% Rat Human -DTXSID2020634 Css NA 0.7831 mg/L PBTK NA 95% Rat Human -DTXSID2020636 Clint NA 1.904 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2020634 Css NA 0.03521 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020634 Css NA 0.164 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020634 Css NA 0.03975 mg/L PBTK NA 50% Rat Human +DTXSID2020634 Css NA 0.1852 mg/L PBTK NA 95% Rat Human +DTXSID2020636 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2020636 Fup 0.0079 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2020636 Vd NA 0.7715 L/kg 1compartment NA NA Human Human -DTXSID2020636 Days.Css NA 28 Days PBTK NA NA Human Human -DTXSID2020636 TK.Half.Life NA 130.2 hours 1compartment NA NA Human Human -DTXSID2020636 Css NA 29.76 mg/L 3compartmentss NA 50% Human Human -DTXSID2020636 Css NA 214.2 mg/L 3compartmentss NA 95% Human Human -DTXSID2020636 Css NA 17.88 mg/L PBTK NA 50% Human Human -DTXSID2020636 Css NA 124.8 mg/L PBTK NA 95% Human Human -DTXSID2020636 Clint NA 1.904 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2020636 Vd NA 2.032 L/kg 1compartment NA NA Human Human +DTXSID2020636 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID2020636 TK.Half.Life NA 119.2 hours 1compartment NA NA Human Human +DTXSID2020636 Css NA 8.272 mg/L 3compartmentss NA 50% Human Human +DTXSID2020636 Css NA 63.93 mg/L 3compartmentss NA 95% Human Human +DTXSID2020636 Css NA 5.268 mg/L PBTK NA 50% Human Human +DTXSID2020636 Css NA 39.14 mg/L PBTK NA 95% Human Human +DTXSID2020636 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2020636 Fup 0.0079 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2020636 Vd NA 0.5707 L/kg 1compartment NA NA Rat Human -DTXSID2020636 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID2020636 TK.Half.Life NA 52.23 hours 1compartment NA NA Rat Human -DTXSID2020636 Css NA 14.63 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020636 Css NA 86.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020636 Css NA 8.142 mg/L PBTK NA 50% Rat Human -DTXSID2020636 Css NA 47.02 mg/L PBTK NA 95% Rat Human -DTXSID2020680 Clint NA 4.945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020680 Fup NA 0.6313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020680 Vd NA 2.553 L/kg 1compartment NA NA Human Human -DTXSID2020680 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020680 TK.Half.Life NA 3.531 hours 1compartment NA NA Human Human -DTXSID2020680 Css NA 0.08838 mg/L 3compartmentss NA 50% Human Human -DTXSID2020680 Css NA 0.9499 mg/L 3compartmentss NA 95% Human Human -DTXSID2020680 Css NA 0.1042 mg/L PBTK NA 50% Human Human -DTXSID2020680 Css NA 0.7678 mg/L PBTK NA 95% Human Human -DTXSID2020680 Clint NA 4.945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020680 Fup NA 0.6313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020680 Vd NA 2.519 L/kg 1compartment NA NA Rat Human +DTXSID2020636 Vd NA 1.504 L/kg 1compartment NA NA Rat Human +DTXSID2020636 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID2020636 TK.Half.Life NA 36.58 hours 1compartment NA NA Rat Human +DTXSID2020636 Css NA 0.4106 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020636 Css NA 3.318 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020636 Css NA 0.2538 mg/L PBTK NA 50% Rat Human +DTXSID2020636 Css NA 1.953 mg/L PBTK NA 95% Rat Human +DTXSID2020680 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020680 Fup 0.595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020680 Vd NA 1.955 L/kg 1compartment NA NA Human Human +DTXSID2020680 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2020680 TK.Half.Life NA 21.26 hours 1compartment NA NA Human Human +DTXSID2020680 Css NA 0.9158 mg/L 3compartmentss NA 50% Human Human +DTXSID2020680 Css NA 7.567 mg/L 3compartmentss NA 95% Human Human +DTXSID2020680 Css NA 0.9556 mg/L PBTK NA 50% Human Human +DTXSID2020680 Css NA 5.131 mg/L PBTK NA 95% Human Human +DTXSID2020680 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020680 Fup 0.595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020680 Vd NA 1.925 L/kg 1compartment NA NA Rat Human DTXSID2020680 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020680 TK.Half.Life NA 1.967 hours 1compartment NA NA Rat Human -DTXSID2020680 Css NA 0.04068 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020680 Css NA 0.4018 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020680 Css NA 0.04823 mg/L PBTK NA 50% Rat Human -DTXSID2020680 Css NA 0.2853 mg/L PBTK NA 95% Rat Human +DTXSID2020680 TK.Half.Life NA 7.132 hours 1compartment NA NA Rat Human +DTXSID2020680 Css NA 0.05544 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020680 Css NA 0.4382 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020680 Css NA 0.05856 mg/L PBTK NA 50% Rat Human +DTXSID2020680 Css NA 0.2894 mg/L PBTK NA 95% Rat Human DTXSID2020684 Clint NA 0.1151 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2020684 Fup NA 0.0566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2020684 Vd NA 2.489 L/kg 1compartment NA NA Human Human -DTXSID2020684 Days.Css NA 166 Days PBTK NA NA Human Human +DTXSID2020684 Days.Css NA 167 Days PBTK NA NA Human Human DTXSID2020684 TK.Half.Life NA 676.9 hours 1compartment NA NA Human Human -DTXSID2020684 Css NA 35.6 mg/L 3compartmentss NA 50% Human Human -DTXSID2020684 Css NA 114.7 mg/L 3compartmentss NA 95% Human Human -DTXSID2020684 Css NA 24.11 mg/L PBTK NA 50% Human Human -DTXSID2020684 Css NA 72.02 mg/L PBTK NA 95% Human Human +DTXSID2020684 Css NA 30.62 mg/L 3compartmentss NA 50% Human Human +DTXSID2020684 Css NA 102.2 mg/L 3compartmentss NA 95% Human Human +DTXSID2020684 Css NA 20.68 mg/L PBTK NA 50% Human Human +DTXSID2020684 Css NA 64.14 mg/L PBTK NA 95% Human Human DTXSID2020684 Clint NA 0.1151 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2020684 Fup NA 0.0566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2020684 Vd NA 1.866 L/kg 1compartment NA NA Rat Human DTXSID2020684 Days.Css NA 47 Days PBTK NA NA Rat Human DTXSID2020684 TK.Half.Life NA 94.96 hours 1compartment NA NA Rat Human -DTXSID2020684 Css NA 11.42 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020684 Css NA 29.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020684 Css NA 7.32 mg/L PBTK NA 50% Rat Human -DTXSID2020684 Css NA 17.49 mg/L PBTK NA 95% Rat Human +DTXSID2020684 Css NA 0.8712 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020684 Css NA 4.107 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020684 Css NA 0.5699 mg/L PBTK NA 50% Rat Human +DTXSID2020684 Css NA 2.526 mg/L PBTK NA 95% Rat Human DTXSID2020686 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2020686 Fup 0.0165 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2020686 Vd NA 1.728 L/kg 1compartment NA NA Human Human DTXSID2020686 Days.Css NA 287 Days PBTK NA NA Human Human DTXSID2020686 TK.Half.Life NA 1106 hours 1compartment NA NA Human Human -DTXSID2020686 Css NA 75.76 mg/L 3compartmentss NA 50% Human Human -DTXSID2020686 Css NA 265.2 mg/L 3compartmentss NA 95% Human Human -DTXSID2020686 Css NA 48.01 mg/L PBTK NA 50% Human Human -DTXSID2020686 Css NA 158.3 mg/L PBTK NA 95% Human Human +DTXSID2020686 Css NA 64.04 mg/L 3compartmentss NA 50% Human Human +DTXSID2020686 Css NA 211 mg/L 3compartmentss NA 95% Human Human +DTXSID2020686 Css NA 41.22 mg/L PBTK NA 50% Human Human +DTXSID2020686 Css NA 135.8 mg/L PBTK NA 95% Human Human DTXSID2020686 Clint 5.288 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID2020686 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID2020686 Css NA 8.933 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2020686 Css NA 59.66 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2020686 Css NA 0.619 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2020686 Css NA 5.605 mg/L 3compartmentss NA 95% Rat Rat DTXSID2020713 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2020713 Fup 0.274 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2020713 Vd NA 0.4282 L/kg 1compartment NA NA Human Human DTXSID2020713 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID2020713 TK.Half.Life NA 10.13 hours 1compartment NA NA Human Human -DTXSID2020713 Css NA 0.7874 mg/L 3compartmentss NA 50% Human Human -DTXSID2020713 Css NA 3.049 mg/L 3compartmentss NA 95% Human Human -DTXSID2020713 Css NA 1.319 mg/L PBTK NA 50% Human Human -DTXSID2020713 Css NA 3.636 mg/L PBTK NA 95% Human Human +DTXSID2020713 Css NA 0.646 mg/L 3compartmentss NA 50% Human Human +DTXSID2020713 Css NA 1.974 mg/L 3compartmentss NA 95% Human Human +DTXSID2020713 Css NA 1.098 mg/L PBTK NA 50% Human Human +DTXSID2020713 Css NA 3.356 mg/L PBTK NA 95% Human Human DTXSID2020713 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2020713 Fup 0.274 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2020713 Vd NA 0.4317 L/kg 1compartment NA NA Rat Human DTXSID2020713 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2020713 TK.Half.Life NA 3.474 hours 1compartment NA NA Rat Human -DTXSID2020713 Css NA 0.276 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020713 Css NA 0.9612 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020713 Css NA 0.4803 mg/L PBTK NA 50% Rat Human -DTXSID2020713 Css NA 1.048 mg/L PBTK NA 95% Rat Human -DTXSID2020717 Clint NA 46.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020717 Fup NA 0.0721 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020717 Vd NA 1.641 L/kg 1compartment NA NA Human Human +DTXSID2020713 Css NA 0.00359 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020713 Css NA 0.01275 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020713 Css NA 0.00612 mg/L PBTK NA 50% Rat Human +DTXSID2020713 Css NA 0.02176 mg/L PBTK NA 95% Rat Human +DTXSID2020717 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020717 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020717 Vd NA 1.404 L/kg 1compartment NA NA Human Human DTXSID2020717 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020717 TK.Half.Life NA 3.62 hours 1compartment NA NA Human Human -DTXSID2020717 Css NA 0.2188 mg/L 3compartmentss NA 50% Human Human -DTXSID2020717 Css NA 1.683 mg/L 3compartmentss NA 95% Human Human -DTXSID2020717 Css NA 0.1434 mg/L PBTK NA 50% Human Human -DTXSID2020717 Css NA 1.063 mg/L PBTK NA 95% Human Human -DTXSID2020717 Clint NA 46.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020717 Fup NA 0.0721 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020717 Vd NA 1.241 L/kg 1compartment NA NA Rat Human +DTXSID2020717 TK.Half.Life NA 9.104 hours 1compartment NA NA Human Human +DTXSID2020717 Css NA 0.9702 mg/L 3compartmentss NA 50% Human Human +DTXSID2020717 Css NA 8.702 mg/L 3compartmentss NA 95% Human Human +DTXSID2020717 Css NA 0.6048 mg/L PBTK NA 50% Human Human +DTXSID2020717 Css NA 5.262 mg/L PBTK NA 95% Human Human +DTXSID2020717 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020717 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020717 Vd NA 1.048 L/kg 1compartment NA NA Rat Human DTXSID2020717 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020717 TK.Half.Life NA 1.324 hours 1compartment NA NA Rat Human -DTXSID2020717 Css NA 0.1233 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020717 Css NA 0.7344 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020717 Css NA 0.07641 mg/L PBTK NA 50% Rat Human -DTXSID2020717 Css NA 0.4335 mg/L PBTK NA 95% Rat Human +DTXSID2020717 TK.Half.Life NA 3.605 hours 1compartment NA NA Rat Human +DTXSID2020717 Css NA 0.1249 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020717 Css NA 0.8506 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020717 Css NA 0.07602 mg/L PBTK NA 50% Rat Human +DTXSID2020717 Css NA 0.4963 mg/L PBTK NA 95% Rat Human +DTXSID2020767 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020767 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020767 Vd NA 0.9236 L/kg 1compartment NA NA Human Human +DTXSID2020767 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2020767 TK.Half.Life NA 2.028 hours 1compartment NA NA Human Human +DTXSID2020767 Css NA 0.2088 mg/L 3compartmentss NA 50% Human Human +DTXSID2020767 Css NA 1.674 mg/L 3compartmentss NA 95% Human Human +DTXSID2020767 Css NA 0.1377 mg/L PBTK NA 50% Human Human +DTXSID2020767 Css NA 1.037 mg/L PBTK NA 95% Human Human +DTXSID2020767 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020767 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020767 Vd NA 0.7452 L/kg 1compartment NA NA Rat Human +DTXSID2020767 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2020767 TK.Half.Life NA 0.9052 hours 1compartment NA NA Rat Human +DTXSID2020767 Css NA 0.02682 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020767 Css NA 0.1676 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020767 Css NA 0.01726 mg/L PBTK NA 50% Rat Human +DTXSID2020767 Css NA 0.1007 mg/L PBTK NA 95% Rat Human DTXSID2020846 Clint NA 0.08792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2020846 Fup NA 0.5992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020846 Vd NA 0.5665 L/kg 1compartment NA NA Human Human +DTXSID2020846 Vd NA 0.5528 L/kg 1compartment NA NA Human Human DTXSID2020846 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020846 TK.Half.Life NA 5.161 hours 1compartment NA NA Human Human -DTXSID2020846 Css NA 1.042 mg/L 3compartmentss NA 50% Human Human -DTXSID2020846 Css NA 6.675 mg/L 3compartmentss NA 95% Human Human -DTXSID2020846 Css NA 0.8058 mg/L PBTK NA 50% Human Human -DTXSID2020846 Css NA 4.151 mg/L PBTK NA 95% Human Human +DTXSID2020846 TK.Half.Life NA 4.962 hours 1compartment NA NA Human Human +DTXSID2020846 Css NA 0.8874 mg/L 3compartmentss NA 50% Human Human +DTXSID2020846 Css NA 5.842 mg/L 3compartmentss NA 95% Human Human +DTXSID2020846 Css NA 0.6824 mg/L PBTK NA 50% Human Human +DTXSID2020846 Css NA 3.629 mg/L PBTK NA 95% Human Human DTXSID2020846 Clint NA 0.08792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2020846 Fup NA 0.5992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020846 Vd NA 0.5947 L/kg 1compartment NA NA Rat Human +DTXSID2020846 Vd NA 0.5834 L/kg 1compartment NA NA Rat Human DTXSID2020846 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020846 TK.Half.Life NA 2.007 hours 1compartment NA NA Rat Human -DTXSID2020846 Css NA 0.3064 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020846 Css NA 2.004 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020846 Css NA 0.2267 mg/L PBTK NA 50% Rat Human -DTXSID2020846 Css NA 1.163 mg/L PBTK NA 95% Rat Human +DTXSID2020846 TK.Half.Life NA 1.954 hours 1compartment NA NA Rat Human +DTXSID2020846 Css NA 0.01856 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020846 Css NA 0.1614 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020846 Css NA 0.0139 mg/L PBTK NA 50% Rat Human +DTXSID2020846 Css NA 0.09883 mg/L PBTK NA 95% Rat Human DTXSID2020890 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2020890 Fup NA 0.6784 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020890 Vd NA 0.6597 L/kg 1compartment NA NA Human Human +DTXSID2020890 Fup 0.502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020890 Vd NA 0.4877 L/kg 1compartment NA NA Human Human DTXSID2020890 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020890 TK.Half.Life NA 6.301 hours 1compartment NA NA Human Human -DTXSID2020890 Css NA 1.122 mg/L 3compartmentss NA 50% Human Human -DTXSID2020890 Css NA 7.14 mg/L 3compartmentss NA 95% Human Human -DTXSID2020890 Css NA 0.8976 mg/L PBTK NA 50% Human Human -DTXSID2020890 Css NA 4.461 mg/L PBTK NA 95% Human Human +DTXSID2020890 TK.Half.Life NA 6.284 hours 1compartment NA NA Human Human +DTXSID2020890 Css NA 1.273 mg/L 3compartmentss NA 50% Human Human +DTXSID2020890 Css NA 6.52 mg/L 3compartmentss NA 95% Human Human +DTXSID2020890 Css NA 0.9463 mg/L PBTK NA 50% Human Human +DTXSID2020890 Css NA 4.12 mg/L PBTK NA 95% Human Human DTXSID2020890 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2020890 Fup NA 0.6784 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020890 Vd NA 0.6804 L/kg 1compartment NA NA Rat Human +DTXSID2020890 Fup 0.502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020890 Vd NA 0.5151 L/kg 1compartment NA NA Rat Human DTXSID2020890 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020890 TK.Half.Life NA 2.212 hours 1compartment NA NA Rat Human -DTXSID2020890 Css NA 0.2942 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020890 Css NA 1.866 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020890 Css NA 0.2259 mg/L PBTK NA 50% Rat Human -DTXSID2020890 Css NA 1.095 mg/L PBTK NA 95% Rat Human +DTXSID2020890 TK.Half.Life NA 2.263 hours 1compartment NA NA Rat Human +DTXSID2020890 Css NA 0.02392 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020890 Css NA 0.1609 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020890 Css NA 0.01698 mg/L PBTK NA 50% Rat Human +DTXSID2020890 Css NA 0.1012 mg/L PBTK NA 95% Rat Human DTXSID2020892 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2020892 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2020892 Vd NA 0.9184 L/kg 1compartment NA NA Human Human DTXSID2020892 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2020892 TK.Half.Life NA 1.355 hours 1compartment NA NA Human Human -DTXSID2020892 Css NA 0.14 mg/L 3compartmentss NA 50% Human Human -DTXSID2020892 Css NA 1.022 mg/L 3compartmentss NA 95% Human Human -DTXSID2020892 Css NA 0.1312 mg/L PBTK NA 50% Human Human -DTXSID2020892 Css NA 0.75 mg/L PBTK NA 95% Human Human +DTXSID2020892 Css NA 0.1175 mg/L 3compartmentss NA 50% Human Human +DTXSID2020892 Css NA 0.6773 mg/L 3compartmentss NA 95% Human Human +DTXSID2020892 Css NA 0.1248 mg/L PBTK NA 50% Human Human +DTXSID2020892 Css NA 0.7238 mg/L PBTK NA 95% Human Human DTXSID2020892 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2020892 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2020892 Vd NA 0.931 L/kg 1compartment NA NA Rat Human DTXSID2020892 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2020892 TK.Half.Life NA 0.727 hours 1compartment NA NA Rat Human -DTXSID2020892 Css NA 0.05996 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020892 Css NA 0.4182 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020892 Css NA 0.05653 mg/L PBTK NA 50% Rat Human -DTXSID2020892 Css NA 0.2726 mg/L PBTK NA 95% Rat Human +DTXSID2020892 Css NA 0.01192 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020892 Css NA 0.05848 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020892 Css NA 0.01321 mg/L PBTK NA 50% Rat Human +DTXSID2020892 Css NA 0.06478 mg/L PBTK NA 95% Rat Human DTXSID2020894 Clint 39.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2020894 Fup 0.00959 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2020894 Vd NA 1.591 L/kg 1compartment NA NA Human Human DTXSID2020894 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID2020894 TK.Half.Life NA 14.34 hours 1compartment NA NA Human Human -DTXSID2020894 Css NA 0.9496 mg/L 3compartmentss NA 50% Human Human -DTXSID2020894 Css NA 6.363 mg/L 3compartmentss NA 95% Human Human -DTXSID2020894 Css NA 0.6034 mg/L PBTK NA 50% Human Human -DTXSID2020894 Css NA 3.947 mg/L PBTK NA 95% Human Human +DTXSID2020894 Css NA 0.9261 mg/L 3compartmentss NA 50% Human Human +DTXSID2020894 Css NA 5.866 mg/L 3compartmentss NA 95% Human Human +DTXSID2020894 Css NA 0.5905 mg/L PBTK NA 50% Human Human +DTXSID2020894 Css NA 3.664 mg/L PBTK NA 95% Human Human DTXSID2020894 Clint 39.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2020894 Fup 0.00959 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2020894 Vd NA 1.174 L/kg 1compartment NA NA Rat Human DTXSID2020894 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2020894 TK.Half.Life NA 5.365 hours 1compartment NA NA Rat Human -DTXSID2020894 Css NA 0.5387 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020894 Css NA 2.655 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020894 Css NA 0.3234 mg/L PBTK NA 50% Rat Human -DTXSID2020894 Css NA 1.582 mg/L PBTK NA 95% Rat Human -DTXSID2020898 Clint NA 0.09956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020898 Fup NA 0.7545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020898 Vd NA 1.067 L/kg 1compartment NA NA Human Human -DTXSID2020898 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020898 TK.Half.Life NA 7.88 hours 1compartment NA NA Human Human -DTXSID2020898 Css NA 0.8181 mg/L 3compartmentss NA 50% Human Human -DTXSID2020898 Css NA 5.202 mg/L 3compartmentss NA 95% Human Human -DTXSID2020898 Css NA 0.708 mg/L PBTK NA 50% Human Human -DTXSID2020898 Css NA 3.376 mg/L PBTK NA 95% Human Human -DTXSID2020898 Clint NA 0.09956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020898 Fup NA 0.7545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020898 Vd NA 1.086 L/kg 1compartment NA NA Rat Human +DTXSID2020894 Css NA 0.1218 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020894 Css NA 0.6195 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020894 Css NA 0.07556 mg/L PBTK NA 50% Rat Human +DTXSID2020894 Css NA 0.3825 mg/L PBTK NA 95% Rat Human +DTXSID2020898 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020898 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020898 Vd NA 0.951 L/kg 1compartment NA NA Human Human +DTXSID2020898 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2020898 TK.Half.Life NA 9.857 hours 1compartment NA NA Human Human +DTXSID2020898 Css NA 0.6166 mg/L 3compartmentss NA 50% Human Human +DTXSID2020898 Css NA 4.51 mg/L 3compartmentss NA 95% Human Human +DTXSID2020898 Css NA 0.5172 mg/L PBTK NA 50% Human Human +DTXSID2020898 Css NA 2.885 mg/L PBTK NA 95% Human Human +DTXSID2020898 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020898 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020898 Vd NA 0.9661 L/kg 1compartment NA NA Rat Human DTXSID2020898 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020898 TK.Half.Life NA 2.942 hours 1compartment NA NA Rat Human -DTXSID2020898 Css NA 0.2305 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020898 Css NA 1.503 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020898 Css NA 0.1932 mg/L PBTK NA 50% Rat Human -DTXSID2020898 Css NA 0.9092 mg/L PBTK NA 95% Rat Human +DTXSID2020898 TK.Half.Life NA 3.409 hours 1compartment NA NA Rat Human +DTXSID2020898 Css NA 0.003273 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020898 Css NA 0.02482 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020898 Css NA 0.002628 mg/L PBTK NA 50% Rat Human +DTXSID2020898 Css NA 0.01536 mg/L PBTK NA 95% Rat Human DTXSID2020921 Clint 18.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID2020921 Fup 0.1099 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID2020921 Vd NA 1.042 L/kg 1compartment NA NA Human Human DTXSID2020921 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2020921 TK.Half.Life NA 2.862 hours 1compartment NA NA Human Human -DTXSID2020921 Css NA 0.3083 mg/L 3compartmentss NA 50% Human Human -DTXSID2020921 Css NA 2.46 mg/L 3compartmentss NA 95% Human Human -DTXSID2020921 Css NA 0.2017 mg/L PBTK NA 50% Human Human -DTXSID2020921 Css NA 1.519 mg/L PBTK NA 95% Human Human +DTXSID2020921 Css NA 0.2984 mg/L 3compartmentss NA 50% Human Human +DTXSID2020921 Css NA 2.285 mg/L 3compartmentss NA 95% Human Human +DTXSID2020921 Css NA 0.1942 mg/L PBTK NA 50% Human Human +DTXSID2020921 Css NA 1.44 mg/L PBTK NA 95% Human Human DTXSID2020921 Clint 18.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID2020921 Fup 0.1099 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID2020921 Vd NA 0.8217 L/kg 1compartment NA NA Rat Human DTXSID2020921 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2020921 TK.Half.Life NA 1.25 hours 1compartment NA NA Rat Human -DTXSID2020921 Css NA 0.1719 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020921 Css NA 0.9949 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020921 Css NA 0.1062 mg/L PBTK NA 50% Rat Human -DTXSID2020921 Css NA 0.5802 mg/L PBTK NA 95% Rat Human -DTXSID2020923 Clint NA 2.534 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020923 Fup NA 0.3919 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020923 Vd NA 1.999 L/kg 1compartment NA NA Human Human +DTXSID2020921 Css NA 0.03891 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020921 Css NA 0.2281 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020921 Css NA 0.02493 mg/L PBTK NA 50% Rat Human +DTXSID2020921 Css NA 0.1393 mg/L PBTK NA 95% Rat Human +DTXSID2020923 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020923 Fup 0.419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020923 Vd NA 2.08 L/kg 1compartment NA NA Human Human DTXSID2020923 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020923 TK.Half.Life NA 7.12 hours 1compartment NA NA Human Human -DTXSID2020923 Css NA 0.2965 mg/L 3compartmentss NA 50% Human Human -DTXSID2020923 Css NA 1.873 mg/L 3compartmentss NA 95% Human Human -DTXSID2020923 Css NA 0.2748 mg/L PBTK NA 50% Human Human -DTXSID2020923 Css NA 1.387 mg/L PBTK NA 95% Human Human -DTXSID2020923 Clint NA 2.534 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020923 Fup NA 0.3919 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020923 Vd NA 1.989 L/kg 1compartment NA NA Rat Human +DTXSID2020923 TK.Half.Life NA 3.804 hours 1compartment NA NA Human Human +DTXSID2020923 Css NA 0.1228 mg/L 3compartmentss NA 50% Human Human +DTXSID2020923 Css NA 0.9173 mg/L 3compartmentss NA 95% Human Human +DTXSID2020923 Css NA 0.1158 mg/L PBTK NA 50% Human Human +DTXSID2020923 Css NA 0.7001 mg/L PBTK NA 95% Human Human +DTXSID2020923 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020923 Fup 0.419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020923 Vd NA 2.073 L/kg 1compartment NA NA Rat Human DTXSID2020923 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020923 TK.Half.Life NA 3.859 hours 1compartment NA NA Rat Human -DTXSID2020923 Css NA 0.1322 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020923 Css NA 0.6765 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020923 Css NA 0.1214 mg/L PBTK NA 50% Rat Human -DTXSID2020923 Css NA 0.4569 mg/L PBTK NA 95% Rat Human -DTXSID2020927 Clint NA 180.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020927 Fup NA 0.0139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020927 Vd NA 0.2049 L/kg 1compartment NA NA Human Human +DTXSID2020923 TK.Half.Life NA 2.131 hours 1compartment NA NA Rat Human +DTXSID2020923 Css NA 0.01406 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020923 Css NA 0.07912 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020923 Css NA 0.0135 mg/L PBTK NA 50% Rat Human +DTXSID2020923 Css NA 0.05872 mg/L PBTK NA 95% Rat Human +DTXSID2020927 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020927 Fup 0.0912 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020927 Vd NA 0.9812 L/kg 1compartment NA NA Human Human DTXSID2020927 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020927 TK.Half.Life NA 0.5165 hours 1compartment NA NA Human Human -DTXSID2020927 Css NA 0.296 mg/L 3compartmentss NA 50% Human Human -DTXSID2020927 Css NA 3.443 mg/L 3compartmentss NA 95% Human Human -DTXSID2020927 Css NA 0.1756 mg/L PBTK NA 50% Human Human -DTXSID2020927 Css NA 1.981 mg/L PBTK NA 95% Human Human -DTXSID2020927 Clint NA 180.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020927 Fup NA 0.0139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020927 Vd NA 0.2008 L/kg 1compartment NA NA Rat Human +DTXSID2020927 TK.Half.Life NA 2.505 hours 1compartment NA NA Human Human +DTXSID2020927 Css NA 0.2565 mg/L 3compartmentss NA 50% Human Human +DTXSID2020927 Css NA 2.195 mg/L 3compartmentss NA 95% Human Human +DTXSID2020927 Css NA 0.1963 mg/L PBTK NA 50% Human Human +DTXSID2020927 Css NA 1.471 mg/L PBTK NA 95% Human Human +DTXSID2020927 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020927 Fup 0.0912 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020927 Vd NA 0.9217 L/kg 1compartment NA NA Rat Human DTXSID2020927 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020927 TK.Half.Life NA 0.3029 hours 1compartment NA NA Rat Human -DTXSID2020927 Css NA 0.1747 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020927 Css NA 1.532 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020927 Css NA 0.09584 mg/L PBTK NA 50% Rat Human -DTXSID2020927 Css NA 0.8294 mg/L PBTK NA 95% Rat Human -DTXSID2020929 Clint NA 0.5721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020929 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020929 Vd NA 0.8712 L/kg 1compartment NA NA Human Human +DTXSID2020927 TK.Half.Life NA 1.413 hours 1compartment NA NA Rat Human +DTXSID2020927 Css NA 0.03301 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020927 Css NA 0.2258 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020927 Css NA 0.02496 mg/L PBTK NA 50% Rat Human +DTXSID2020927 Css NA 0.1464 mg/L PBTK NA 95% Rat Human +DTXSID2020929 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020929 Fup 0.718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2020929 Vd NA 0.7125 L/kg 1compartment NA NA Human Human DTXSID2020929 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020929 TK.Half.Life NA 3.02 hours 1compartment NA NA Human Human -DTXSID2020929 Css NA 0.4096 mg/L 3compartmentss NA 50% Human Human -DTXSID2020929 Css NA 2.746 mg/L 3compartmentss NA 95% Human Human -DTXSID2020929 Css NA 0.3528 mg/L PBTK NA 50% Human Human -DTXSID2020929 Css NA 1.843 mg/L PBTK NA 95% Human Human -DTXSID2020929 Clint NA 0.5721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020929 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020929 Vd NA 0.896 L/kg 1compartment NA NA Rat Human +DTXSID2020929 TK.Half.Life NA 6.436 hours 1compartment NA NA Human Human +DTXSID2020929 Css NA 1.043 mg/L 3compartmentss NA 50% Human Human +DTXSID2020929 Css NA 6.48 mg/L 3compartmentss NA 95% Human Human +DTXSID2020929 Css NA 0.8502 mg/L PBTK NA 50% Human Human +DTXSID2020929 Css NA 4.078 mg/L PBTK NA 95% Human Human +DTXSID2020929 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020929 Fup 0.718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2020929 Vd NA 0.7316 L/kg 1compartment NA NA Rat Human DTXSID2020929 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020929 TK.Half.Life NA 1.377 hours 1compartment NA NA Rat Human -DTXSID2020929 Css NA 0.1401 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020929 Css NA 0.8838 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020929 Css NA 0.1195 mg/L PBTK NA 50% Rat Human -DTXSID2020929 Css NA 0.5382 mg/L PBTK NA 95% Rat Human +DTXSID2020929 TK.Half.Life NA 2.248 hours 1compartment NA NA Rat Human +DTXSID2020929 Css NA 0.06249 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020929 Css NA 0.4022 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020929 Css NA 0.0508 mg/L PBTK NA 50% Rat Human +DTXSID2020929 Css NA 0.2459 mg/L PBTK NA 95% Rat Human DTXSID2020977 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2020977 Fup NA 0.5475 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2020977 Vd NA 0.6129 L/kg 1compartment NA NA Human Human +DTXSID2020977 Vd NA 0.6157 L/kg 1compartment NA NA Human Human DTXSID2020977 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2020977 TK.Half.Life NA 7.257 hours 1compartment NA NA Human Human -DTXSID2020977 Css NA 1.37 mg/L 3compartmentss NA 50% Human Human -DTXSID2020977 Css NA 8.287 mg/L 3compartmentss NA 95% Human Human -DTXSID2020977 Css NA 1.061 mg/L PBTK NA 50% Human Human -DTXSID2020977 Css NA 5.232 mg/L PBTK NA 95% Human Human +DTXSID2020977 TK.Half.Life NA 7.29 hours 1compartment NA NA Human Human +DTXSID2020977 Css NA 1.152 mg/L 3compartmentss NA 50% Human Human +DTXSID2020977 Css NA 7.336 mg/L 3compartmentss NA 95% Human Human +DTXSID2020977 Css NA 0.8932 mg/L PBTK NA 50% Human Human +DTXSID2020977 Css NA 4.637 mg/L PBTK NA 95% Human Human DTXSID2020977 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2020977 Fup NA 0.5475 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2020977 Vd NA 0.6269 L/kg 1compartment NA NA Rat Human +DTXSID2020977 Vd NA 0.63 L/kg 1compartment NA NA Rat Human DTXSID2020977 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2020977 TK.Half.Life NA 2.526 hours 1compartment NA NA Rat Human -DTXSID2020977 Css NA 0.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID2020977 Css NA 2.067 mg/L 3compartmentss NA 95% Rat Human -DTXSID2020977 Css NA 0.2667 mg/L PBTK NA 50% Rat Human -DTXSID2020977 Css NA 1.208 mg/L PBTK NA 95% Rat Human -DTXSID2021022 Clint NA 3.614 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021022 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021022 Vd NA 0.7794 L/kg 1compartment NA NA Human Human +DTXSID2020977 TK.Half.Life NA 2.539 hours 1compartment NA NA Rat Human +DTXSID2020977 Css NA 0.02141 mg/L 3compartmentss NA 50% Rat Human +DTXSID2020977 Css NA 0.1801 mg/L 3compartmentss NA 95% Rat Human +DTXSID2020977 Css NA 0.01608 mg/L PBTK NA 50% Rat Human +DTXSID2020977 Css NA 0.1142 mg/L PBTK NA 95% Rat Human +DTXSID2021022 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021022 Fup 0.837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021022 Vd NA 0.6787 L/kg 1compartment NA NA Human Human DTXSID2021022 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021022 TK.Half.Life NA 1.043 hours 1compartment NA NA Human Human -DTXSID2021022 Css NA 0.1241 mg/L 3compartmentss NA 50% Human Human -DTXSID2021022 Css NA 1.037 mg/L 3compartmentss NA 95% Human Human -DTXSID2021022 Css NA 0.1029 mg/L PBTK NA 50% Human Human -DTXSID2021022 Css NA 0.7348 mg/L PBTK NA 95% Human Human -DTXSID2021022 Clint NA 3.614 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021022 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021022 Vd NA 0.8171 L/kg 1compartment NA NA Rat Human +DTXSID2021022 TK.Half.Life NA 5.247 hours 1compartment NA NA Human Human +DTXSID2021022 Css NA 0.8352 mg/L 3compartmentss NA 50% Human Human +DTXSID2021022 Css NA 5.124 mg/L 3compartmentss NA 95% Human Human +DTXSID2021022 Css NA 0.6782 mg/L PBTK NA 50% Human Human +DTXSID2021022 Css NA 3.246 mg/L PBTK NA 95% Human Human +DTXSID2021022 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021022 Fup 0.837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021022 Vd NA 0.7152 L/kg 1compartment NA NA Rat Human DTXSID2021022 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021022 TK.Half.Life NA 0.5714 hours 1compartment NA NA Rat Human -DTXSID2021022 Css NA 0.05566 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021022 Css NA 0.3849 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021022 Css NA 0.04591 mg/L PBTK NA 50% Rat Human -DTXSID2021022 Css NA 0.2371 mg/L PBTK NA 95% Rat Human -DTXSID2021028 Clint NA 0.03814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021028 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021028 Vd NA 1.13 L/kg 1compartment NA NA Human Human +DTXSID2021022 TK.Half.Life NA 1.884 hours 1compartment NA NA Rat Human +DTXSID2021022 Css NA 0.01553 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021022 Css NA 0.1209 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021022 Css NA 0.01199 mg/L PBTK NA 50% Rat Human +DTXSID2021022 Css NA 0.07749 mg/L PBTK NA 95% Rat Human +DTXSID2021026 Clint 11.12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID2021026 Fup 0.2602 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID2021026 Vd NA 2.088 L/kg 1compartment NA NA Human Human +DTXSID2021026 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2021026 TK.Half.Life NA 5.55 hours 1compartment NA NA Human Human +DTXSID2021026 Css NA 0.2277 mg/L 3compartmentss NA 50% Human Human +DTXSID2021026 Css NA 1.392 mg/L 3compartmentss NA 95% Human Human +DTXSID2021026 Css NA 0.1707 mg/L PBTK NA 50% Human Human +DTXSID2021026 Css NA 0.9812 mg/L PBTK NA 95% Human Human +DTXSID2021026 Clint 11.12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID2021026 Fup 0.2602 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID2021026 Vd NA 1.634 L/kg 1compartment NA NA Rat Human +DTXSID2021026 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2021026 TK.Half.Life NA 1.877 hours 1compartment NA NA Rat Human +DTXSID2021026 Css NA 0.02778 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021026 Css NA 0.1251 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021026 Css NA 0.02079 mg/L PBTK NA 50% Rat Human +DTXSID2021026 Css NA 0.08719 mg/L PBTK NA 95% Rat Human +DTXSID2021028 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021028 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021028 Vd NA 0.9027 L/kg 1compartment NA NA Human Human DTXSID2021028 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021028 TK.Half.Life NA 7.025 hours 1compartment NA NA Human Human -DTXSID2021028 Css NA 0.7127 mg/L 3compartmentss NA 50% Human Human -DTXSID2021028 Css NA 4.874 mg/L 3compartmentss NA 95% Human Human -DTXSID2021028 Css NA 0.6502 mg/L PBTK NA 50% Human Human -DTXSID2021028 Css NA 3.302 mg/L PBTK NA 95% Human Human -DTXSID2021028 Clint NA 0.03814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021028 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021028 Vd NA 1.114 L/kg 1compartment NA NA Rat Human +DTXSID2021028 TK.Half.Life NA 0.7452 hours 1compartment NA NA Human Human +DTXSID2021028 Css NA 0.02258 mg/L 3compartmentss NA 50% Human Human +DTXSID2021028 Css NA 0.2766 mg/L 3compartmentss NA 95% Human Human +DTXSID2021028 Css NA 0.01876 mg/L PBTK NA 50% Human Human +DTXSID2021028 Css NA 0.1905 mg/L PBTK NA 95% Human Human +DTXSID2021028 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021028 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021028 Vd NA 0.8876 L/kg 1compartment NA NA Rat Human DTXSID2021028 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021028 TK.Half.Life NA 2.395 hours 1compartment NA NA Rat Human -DTXSID2021028 Css NA 0.187 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021028 Css NA 1.288 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021028 Css NA 0.1681 mg/L PBTK NA 50% Rat Human -DTXSID2021028 Css NA 0.7914 mg/L PBTK NA 95% Rat Human -DTXSID2021070 Clint NA 3.546 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021070 Fup NA 0.0975 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021070 Vd NA 2.13 L/kg 1compartment NA NA Human Human -DTXSID2021070 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2021070 TK.Half.Life NA 33.34 hours 1compartment NA NA Human Human -DTXSID2021070 Css NA 2.177 mg/L 3compartmentss NA 50% Human Human -DTXSID2021070 Css NA 11.39 mg/L 3compartmentss NA 95% Human Human -DTXSID2021070 Css NA 1.492 mg/L PBTK NA 50% Human Human -DTXSID2021070 Css NA 7.315 mg/L PBTK NA 95% Human Human -DTXSID2021070 Clint NA 3.546 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021070 Fup NA 0.0975 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021070 Vd NA 1.625 L/kg 1compartment NA NA Rat Human -DTXSID2021070 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2021070 TK.Half.Life NA 9.846 hours 1compartment NA NA Rat Human -DTXSID2021070 Css NA 1.088 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021070 Css NA 4.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021070 Css NA 0.7064 mg/L PBTK NA 50% Rat Human -DTXSID2021070 Css NA 2.593 mg/L PBTK NA 95% Rat Human +DTXSID2021028 TK.Half.Life NA 0.3591 hours 1compartment NA NA Rat Human +DTXSID2021028 Css NA 0.0008224 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021028 Css NA 0.01093 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021028 Css NA 0.0006658 mg/L PBTK NA 50% Rat Human +DTXSID2021028 Css NA 0.007483 mg/L PBTK NA 95% Rat Human +DTXSID2021070 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021070 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021070 Vd NA 2.333 L/kg 1compartment NA NA Human Human +DTXSID2021070 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2021070 TK.Half.Life NA 7.271 hours 1compartment NA NA Human Human +DTXSID2021070 Css NA 0.313 mg/L 3compartmentss NA 50% Human Human +DTXSID2021070 Css NA 2.098 mg/L 3compartmentss NA 95% Human Human +DTXSID2021070 Css NA 0.2189 mg/L PBTK NA 50% Human Human +DTXSID2021070 Css NA 1.409 mg/L PBTK NA 95% Human Human +DTXSID2021070 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021070 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021070 Vd NA 1.786 L/kg 1compartment NA NA Rat Human +DTXSID2021070 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2021070 TK.Half.Life NA 2.194 hours 1compartment NA NA Rat Human +DTXSID2021070 Css NA 0.04044 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021070 Css NA 0.2127 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021070 Css NA 0.02804 mg/L PBTK NA 50% Rat Human +DTXSID2021070 Css NA 0.1429 mg/L PBTK NA 95% Rat Human DTXSID2021151 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2021151 Fup 0.04105 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2021151 Vd NA 2.134 L/kg 1compartment NA NA Human Human -DTXSID2021151 Days.Css NA 113 Days PBTK NA NA Human Human +DTXSID2021151 Days.Css NA 112 Days PBTK NA NA Human Human DTXSID2021151 TK.Half.Life NA 459 hours 1compartment NA NA Human Human -DTXSID2021151 Css NA 23.27 mg/L 3compartmentss NA 50% Human Human -DTXSID2021151 Css NA 147.9 mg/L 3compartmentss NA 95% Human Human -DTXSID2021151 Css NA 21.49 mg/L PBTK NA 50% Human Human -DTXSID2021151 Css NA 99.29 mg/L PBTK NA 95% Human Human +DTXSID2021151 Css NA 22.72 mg/L 3compartmentss NA 50% Human Human +DTXSID2021151 Css NA 137.1 mg/L 3compartmentss NA 95% Human Human +DTXSID2021151 Css NA 20.96 mg/L PBTK NA 50% Human Human +DTXSID2021151 Css NA 94.82 mg/L PBTK NA 95% Human Human DTXSID2021151 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2021151 Fup 0.04105 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2021151 Vd NA 1.868 L/kg 1compartment NA NA Rat Human -DTXSID2021151 Days.Css NA 31 Days PBTK NA NA Rat Human +DTXSID2021151 Days.Css NA 30 Days PBTK NA NA Rat Human DTXSID2021151 TK.Half.Life NA 109.1 hours 1compartment NA NA Rat Human -DTXSID2021151 Css NA 6.279 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021151 Css NA 34.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021151 Css NA 5.622 mg/L PBTK NA 50% Rat Human -DTXSID2021151 Css NA 21.94 mg/L PBTK NA 95% Rat Human -DTXSID2021159 Clint NA 2.867 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021159 Fup NA 0.7922 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021159 Vd NA 1.694 L/kg 1compartment NA NA Human Human -DTXSID2021159 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021159 TK.Half.Life NA 3.506 hours 1compartment NA NA Human Human -DTXSID2021159 Css NA 0.1773 mg/L 3compartmentss NA 50% Human Human -DTXSID2021159 Css NA 1.359 mg/L 3compartmentss NA 95% Human Human -DTXSID2021159 Css NA 0.1639 mg/L PBTK NA 50% Human Human -DTXSID2021159 Css NA 0.9605 mg/L PBTK NA 95% Human Human -DTXSID2021159 Clint NA 2.867 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021159 Fup NA 0.7922 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021159 Vd NA 1.472 L/kg 1compartment NA NA Rat Human +DTXSID2021151 Css NA 1.42 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021151 Css NA 7.665 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021151 Css NA 1.315 mg/L PBTK NA 50% Rat Human +DTXSID2021151 Css NA 5.027 mg/L PBTK NA 95% Rat Human +DTXSID2021159 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021159 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021159 Vd NA 0.6741 L/kg 1compartment NA NA Human Human +DTXSID2021159 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2021159 TK.Half.Life NA 11.36 hours 1compartment NA NA Human Human +DTXSID2021159 Css NA 1.794 mg/L 3compartmentss NA 50% Human Human +DTXSID2021159 Css NA 7.838 mg/L 3compartmentss NA 95% Human Human +DTXSID2021159 Css NA 1.35 mg/L PBTK NA 50% Human Human +DTXSID2021159 Css NA 4.962 mg/L PBTK NA 95% Human Human +DTXSID2021159 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021159 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021159 Vd NA 0.6483 L/kg 1compartment NA NA Rat Human DTXSID2021159 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021159 TK.Half.Life NA 1.445 hours 1compartment NA NA Rat Human -DTXSID2021159 Css NA 0.0793 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021159 Css NA 0.5413 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021159 Css NA 0.07207 mg/L PBTK NA 50% Rat Human -DTXSID2021159 Css NA 0.3493 mg/L PBTK NA 95% Rat Human +DTXSID2021159 TK.Half.Life NA 3.687 hours 1compartment NA NA Rat Human +DTXSID2021159 Css NA 0.1147 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021159 Css NA 0.4254 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021159 Css NA 0.08512 mg/L PBTK NA 50% Rat Human +DTXSID2021159 Css NA 0.2631 mg/L PBTK NA 95% Rat Human DTXSID2021232 Clint NA 63.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021232 Fup NA 0.0157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021232 Vd NA 0.1721 L/kg 1compartment NA NA Human Human +DTXSID2021232 Vd NA 0.1655 L/kg 1compartment NA NA Human Human DTXSID2021232 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021232 TK.Half.Life NA 0.8359 hours 1compartment NA NA Human Human -DTXSID2021232 Css NA 0.7656 mg/L 3compartmentss NA 50% Human Human -DTXSID2021232 Css NA 7.964 mg/L 3compartmentss NA 95% Human Human -DTXSID2021232 Css NA 0.4424 mg/L PBTK NA 50% Human Human -DTXSID2021232 Css NA 4.61 mg/L PBTK NA 95% Human Human +DTXSID2021232 TK.Half.Life NA 0.1941 hours 1compartment NA NA Human Human +DTXSID2021232 Css NA 0.02524 mg/L 3compartmentss NA 50% Human Human +DTXSID2021232 Css NA 0.3253 mg/L 3compartmentss NA 95% Human Human +DTXSID2021232 Css NA 0.01472 mg/L PBTK NA 50% Human Human +DTXSID2021232 Css NA 0.1893 mg/L PBTK NA 95% Human Human DTXSID2021232 Clint NA 63.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021232 Fup NA 0.0157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021232 Vd NA 0.1704 L/kg 1compartment NA NA Rat Human +DTXSID2021232 Vd NA 0.165 L/kg 1compartment NA NA Rat Human DTXSID2021232 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021232 TK.Half.Life NA 0.532 hours 1compartment NA NA Rat Human -DTXSID2021232 Css NA 0.4362 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021232 Css NA 3.582 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021232 Css NA 0.237 mg/L PBTK NA 50% Rat Human -DTXSID2021232 Css NA 1.937 mg/L PBTK NA 95% Rat Human -DTXSID2021234 Clint NA 113.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021234 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021234 Vd NA 0.1966 L/kg 1compartment NA NA Human Human +DTXSID2021232 TK.Half.Life NA 0.09283 hours 1compartment NA NA Rat Human +DTXSID2021232 Css NA 0.000979 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021232 Css NA 0.01531 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021232 Css NA 0.0005366 mg/L PBTK NA 50% Rat Human +DTXSID2021232 Css NA 0.008464 mg/L PBTK NA 95% Rat Human +DTXSID2021234 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021234 Fup 0.0656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021234 Vd NA 0.1927 L/kg 1compartment NA NA Human Human DTXSID2021234 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021234 TK.Half.Life NA 0.6589 hours 1compartment NA NA Human Human -DTXSID2021234 Css NA 0.4601 mg/L 3compartmentss NA 50% Human Human -DTXSID2021234 Css NA 4.902 mg/L 3compartmentss NA 95% Human Human -DTXSID2021234 Css NA 0.27 mg/L PBTK NA 50% Human Human -DTXSID2021234 Css NA 2.876 mg/L PBTK NA 95% Human Human -DTXSID2021234 Clint NA 113.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021234 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021234 Vd NA 0.1876 L/kg 1compartment NA NA Rat Human +DTXSID2021234 TK.Half.Life NA 0.6762 hours 1compartment NA NA Human Human +DTXSID2021234 Css NA 0.2277 mg/L 3compartmentss NA 50% Human Human +DTXSID2021234 Css NA 1.92 mg/L 3compartmentss NA 95% Human Human +DTXSID2021234 Css NA 0.1354 mg/L PBTK NA 50% Human Human +DTXSID2021234 Css NA 1.12 mg/L PBTK NA 95% Human Human +DTXSID2021234 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021234 Fup 0.0656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021234 Vd NA 0.1941 L/kg 1compartment NA NA Rat Human DTXSID2021234 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021234 TK.Half.Life NA 0.3903 hours 1compartment NA NA Rat Human -DTXSID2021234 Css NA 0.2684 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021234 Css NA 2.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021234 Css NA 0.1464 mg/L PBTK NA 50% Rat Human -DTXSID2021234 Css NA 1.289 mg/L PBTK NA 95% Rat Human -DTXSID2021236 Clint NA 24.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021236 Fup NA 0.5996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021236 Vd NA 0.714 L/kg 1compartment NA NA Human Human +DTXSID2021234 TK.Half.Life NA 0.4176 hours 1compartment NA NA Rat Human +DTXSID2021234 Css NA 0.002465 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021234 Css NA 0.01683 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021234 Css NA 0.00137 mg/L PBTK NA 50% Rat Human +DTXSID2021234 Css NA 0.009226 mg/L PBTK NA 95% Rat Human +DTXSID2021236 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021236 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021236 Vd NA 0.697 L/kg 1compartment NA NA Human Human DTXSID2021236 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021236 TK.Half.Life NA 0.6313 hours 1compartment NA NA Human Human -DTXSID2021236 Css NA 0.03235 mg/L 3compartmentss NA 50% Human Human -DTXSID2021236 Css NA 0.3445 mg/L 3compartmentss NA 95% Human Human -DTXSID2021236 Css NA 0.02549 mg/L PBTK NA 50% Human Human -DTXSID2021236 Css NA 0.2298 mg/L PBTK NA 95% Human Human -DTXSID2021236 Clint NA 24.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021236 Fup NA 0.5996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021236 Vd NA 0.7177 L/kg 1compartment NA NA Rat Human +DTXSID2021236 TK.Half.Life NA 8.537 hours 1compartment NA NA Human Human +DTXSID2021236 Css NA 1.329 mg/L 3compartmentss NA 50% Human Human +DTXSID2021236 Css NA 7.805 mg/L 3compartmentss NA 95% Human Human +DTXSID2021236 Css NA 1.049 mg/L PBTK NA 50% Human Human +DTXSID2021236 Css NA 4.981 mg/L PBTK NA 95% Human Human +DTXSID2021236 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021236 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021236 Vd NA 0.6933 L/kg 1compartment NA NA Rat Human DTXSID2021236 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021236 TK.Half.Life NA 0.3121 hours 1compartment NA NA Rat Human -DTXSID2021236 Css NA 0.01703 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021236 Css NA 0.1564 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021236 Css NA 0.0131 mg/L PBTK NA 50% Rat Human -DTXSID2021236 Css NA 0.09826 mg/L PBTK NA 95% Rat Human +DTXSID2021236 TK.Half.Life NA 2.877 hours 1compartment NA NA Rat Human +DTXSID2021236 Css NA 0.08152 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021236 Css NA 0.4358 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021236 Css NA 0.0638 mg/L PBTK NA 50% Rat Human +DTXSID2021236 Css NA 0.2669 mg/L PBTK NA 95% Rat Human DTXSID2021238 Clint 14.48 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID2021238 Fup 0.7448 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID2021238 Vd NA 1.039 L/kg 1compartment NA NA Human Human DTXSID2021238 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2021238 TK.Half.Life NA 0.9243 hours 1compartment NA NA Human Human -DTXSID2021238 Css NA 0.0433 mg/L 3compartmentss NA 50% Human Human -DTXSID2021238 Css NA 0.3957 mg/L 3compartmentss NA 95% Human Human -DTXSID2021238 Css NA 0.03676 mg/L PBTK NA 50% Human Human -DTXSID2021238 Css NA 0.2834 mg/L PBTK NA 95% Human Human +DTXSID2021238 Css NA 0.03288 mg/L 3compartmentss NA 50% Human Human +DTXSID2021238 Css NA 0.3451 mg/L 3compartmentss NA 95% Human Human +DTXSID2021238 Css NA 0.02816 mg/L PBTK NA 50% Human Human +DTXSID2021238 Css NA 0.2516 mg/L PBTK NA 95% Human Human DTXSID2021238 Clint 14.48 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID2021238 Fup 0.7448 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID2021238 Vd NA 0.9921 L/kg 1compartment NA NA Rat Human DTXSID2021238 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2021238 TK.Half.Life NA 0.4426 hours 1compartment NA NA Rat Human -DTXSID2021238 Css NA 0.02119 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021238 Css NA 0.1818 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021238 Css NA 0.01803 mg/L PBTK NA 50% Rat Human -DTXSID2021238 Css NA 0.1186 mg/L PBTK NA 95% Rat Human -DTXSID2021282 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021282 Fup NA 0.947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021282 Vd NA 0.5139 L/kg 1compartment NA NA Human Human +DTXSID2021238 Css NA 0.001154 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021238 Css NA 0.0142 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021238 Css NA 0.0009724 mg/L PBTK NA 50% Rat Human +DTXSID2021238 Css NA 0.009846 mg/L PBTK NA 95% Rat Human +DTXSID20212769 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20212769 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20212769 Vd NA 1.269 L/kg 1compartment NA NA Human Human +DTXSID20212769 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20212769 TK.Half.Life NA 6.418 hours 1compartment NA NA Human Human +DTXSID20212769 Css NA 0.5025 mg/L 3compartmentss NA 50% Human Human +DTXSID20212769 Css NA 3.57 mg/L 3compartmentss NA 95% Human Human +DTXSID20212769 Css NA 0.3398 mg/L PBTK NA 50% Human Human +DTXSID20212769 Css NA 2.259 mg/L PBTK NA 95% Human Human +DTXSID20212769 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20212769 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20212769 Vd NA 0.9954 L/kg 1compartment NA NA Rat Human +DTXSID20212769 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20212769 TK.Half.Life NA 2.661 hours 1compartment NA NA Rat Human +DTXSID20212769 Css NA 0.01402 mg/L 3compartmentss NA 50% Rat Human +DTXSID20212769 Css NA 0.1184 mg/L 3compartmentss NA 95% Rat Human +DTXSID20212769 Css NA 0.009058 mg/L PBTK NA 50% Rat Human +DTXSID20212769 Css NA 0.07192 mg/L PBTK NA 95% Rat Human +DTXSID2021282 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021282 Fup 0.855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021282 Vd NA 0.5856 L/kg 1compartment NA NA Human Human DTXSID2021282 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021282 TK.Half.Life NA 3.51 hours 1compartment NA NA Human Human -DTXSID2021282 Css NA 0.9505 mg/L 3compartmentss NA 50% Human Human -DTXSID2021282 Css NA 3.268 mg/L 3compartmentss NA 95% Human Human -DTXSID2021282 Css NA 0.716 mg/L PBTK NA 50% Human Human -DTXSID2021282 Css NA 2.154 mg/L PBTK NA 95% Human Human -DTXSID2021282 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021282 Fup NA 0.947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021282 Vd NA 0.5433 L/kg 1compartment NA NA Rat Human +DTXSID2021282 TK.Half.Life NA 4.432 hours 1compartment NA NA Human Human +DTXSID2021282 Css NA 0.5663 mg/L 3compartmentss NA 50% Human Human +DTXSID2021282 Css NA 3.298 mg/L 3compartmentss NA 95% Human Human +DTXSID2021282 Css NA 0.4364 mg/L PBTK NA 50% Human Human +DTXSID2021282 Css NA 2.072 mg/L PBTK NA 95% Human Human +DTXSID2021282 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021282 Fup 0.855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021282 Vd NA 0.615 L/kg 1compartment NA NA Rat Human DTXSID2021282 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021282 TK.Half.Life NA 1.265 hours 1compartment NA NA Rat Human -DTXSID2021282 Css NA 0.2479 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021282 Css NA 0.7607 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021282 Css NA 0.1804 mg/L PBTK NA 50% Rat Human -DTXSID2021282 Css NA 0.4662 mg/L PBTK NA 95% Rat Human -DTXSID2021286 Clint NA 4.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021286 Fup NA 0.6481 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021286 Vd NA 1.532 L/kg 1compartment NA NA Human Human +DTXSID2021282 TK.Half.Life NA 1.586 hours 1compartment NA NA Rat Human +DTXSID2021282 Css NA 0.002866 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021282 Css NA 0.018 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021282 Css NA 0.00214 mg/L PBTK NA 50% Rat Human +DTXSID2021282 Css NA 0.01093 mg/L PBTK NA 95% Rat Human +DTXSID2021286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021286 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021286 Vd NA 1.077 L/kg 1compartment NA NA Human Human DTXSID2021286 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021286 TK.Half.Life NA 2.673 hours 1compartment NA NA Human Human -DTXSID2021286 Css NA 0.1389 mg/L 3compartmentss NA 50% Human Human -DTXSID2021286 Css NA 1.238 mg/L 3compartmentss NA 95% Human Human -DTXSID2021286 Css NA 0.1218 mg/L PBTK NA 50% Human Human -DTXSID2021286 Css NA 0.8531 mg/L PBTK NA 95% Human Human -DTXSID2021286 Clint NA 4.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021286 Fup NA 0.6481 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021286 Vd NA 1.326 L/kg 1compartment NA NA Rat Human +DTXSID2021286 TK.Half.Life NA 1.314 hours 1compartment NA NA Human Human +DTXSID2021286 Css NA 0.05844 mg/L 3compartmentss NA 50% Human Human +DTXSID2021286 Css NA 0.4538 mg/L 3compartmentss NA 95% Human Human +DTXSID2021286 Css NA 0.04479 mg/L PBTK NA 50% Human Human +DTXSID2021286 Css NA 0.3159 mg/L PBTK NA 95% Human Human +DTXSID2021286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021286 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021286 Vd NA 0.9257 L/kg 1compartment NA NA Rat Human DTXSID2021286 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021286 TK.Half.Life NA 1.152 hours 1compartment NA NA Rat Human -DTXSID2021286 Css NA 0.06544 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021286 Css NA 0.496 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021286 Css NA 0.05635 mg/L PBTK NA 50% Rat Human -DTXSID2021286 Css NA 0.3118 mg/L PBTK NA 95% Rat Human +DTXSID2021286 TK.Half.Life NA 0.5767 hours 1compartment NA NA Rat Human +DTXSID2021286 Css NA 0.007428 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021286 Css NA 0.04311 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021286 Css NA 0.005631 mg/L PBTK NA 50% Rat Human +DTXSID2021286 Css NA 0.02917 mg/L PBTK NA 95% Rat Human DTXSID2021288 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021288 Fup NA 0.9059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021288 Vd NA 0.6308 L/kg 1compartment NA NA Human Human +DTXSID2021288 Vd NA 0.631 L/kg 1compartment NA NA Human Human DTXSID2021288 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021288 TK.Half.Life NA 4.504 hours 1compartment NA NA Human Human -DTXSID2021288 Css NA 0.9555 mg/L 3compartmentss NA 50% Human Human -DTXSID2021288 Css NA 5.151 mg/L 3compartmentss NA 95% Human Human -DTXSID2021288 Css NA 0.7639 mg/L PBTK NA 50% Human Human -DTXSID2021288 Css NA 3.316 mg/L PBTK NA 95% Human Human +DTXSID2021288 TK.Half.Life NA 4.507 hours 1compartment NA NA Human Human +DTXSID2021288 Css NA 0.8136 mg/L 3compartmentss NA 50% Human Human +DTXSID2021288 Css NA 4.494 mg/L 3compartmentss NA 95% Human Human +DTXSID2021288 Css NA 0.655 mg/L PBTK NA 50% Human Human +DTXSID2021288 Css NA 2.936 mg/L PBTK NA 95% Human Human DTXSID2021288 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021288 Fup NA 0.9059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021288 Vd NA 0.6837 L/kg 1compartment NA NA Rat Human +DTXSID2021288 Vd NA 0.6838 L/kg 1compartment NA NA Rat Human DTXSID2021288 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2021288 TK.Half.Life NA 1.664 hours 1compartment NA NA Rat Human -DTXSID2021288 Css NA 0.2456 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021288 Css NA 1.336 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021288 Css NA 0.1903 mg/L PBTK NA 50% Rat Human -DTXSID2021288 Css NA 0.7965 mg/L PBTK NA 95% Rat Human -DTXSID2021311 Clint 40.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2021311 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021311 Vd NA 3.416 L/kg 1compartment NA NA Human Human -DTXSID2021311 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID2021311 TK.Half.Life NA 56.4 hours 1compartment NA NA Human Human -DTXSID2021311 Css NA 1.853 mg/L 3compartmentss NA 50% Human Human -DTXSID2021311 Css NA 13.98 mg/L 3compartmentss NA 95% Human Human -DTXSID2021311 Css NA 1.322 mg/L PBTK NA 50% Human Human -DTXSID2021311 Css NA 9.804 mg/L PBTK NA 95% Human Human -DTXSID2021311 Clint 40.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2021311 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021311 Vd NA 2.568 L/kg 1compartment NA NA Rat Human -DTXSID2021311 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2021311 TK.Half.Life NA 7.905 hours 1compartment NA NA Rat Human -DTXSID2021311 Css NA 1.064 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021311 Css NA 6.337 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021311 Css NA 0.7269 mg/L PBTK NA 50% Rat Human -DTXSID2021311 Css NA 4.252 mg/L PBTK NA 95% Rat Human -DTXSID2021315 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021315 Fup NA 0.0248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021315 Vd NA 8.238 L/kg 1compartment NA NA Human Human -DTXSID2021315 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID2021315 TK.Half.Life NA 391400 hours 1compartment NA NA Human Human -DTXSID2021315 Css NA 3473 mg/L 3compartmentss NA 50% Human Human -DTXSID2021315 Css NA 8145 mg/L 3compartmentss NA 95% Human Human -DTXSID2021315 Css NA 3642 mg/L PBTK NA 50% Human Human -DTXSID2021315 Css NA 7904 mg/L PBTK NA 95% Human Human -DTXSID2021315 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021315 Fup NA 0.0248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021315 Vd NA 6.43 L/kg 1compartment NA NA Rat Human -DTXSID2021315 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID2021315 TK.Half.Life NA 25230 hours 1compartment NA NA Rat Human -DTXSID2021315 Css NA 929.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021315 Css NA 1446 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021315 Css NA 976.7 mg/L PBTK NA 50% Rat Human -DTXSID2021315 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID2021363 Clint NA 2.886 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021363 Fup NA 0.6069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021363 Vd NA 1.292 L/kg 1compartment NA NA Human Human +DTXSID2021288 Css NA 0.01551 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021288 Css NA 0.1032 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021288 Css NA 0.01201 mg/L PBTK NA 50% Rat Human +DTXSID2021288 Css NA 0.0669 mg/L PBTK NA 95% Rat Human +DTXSID2021363 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021363 Fup 0.519 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021363 Vd NA 1.316 L/kg 1compartment NA NA Human Human DTXSID2021363 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021363 TK.Half.Life NA 3.122 hours 1compartment NA NA Human Human -DTXSID2021363 Css NA 0.2178 mg/L 3compartmentss NA 50% Human Human -DTXSID2021363 Css NA 1.801 mg/L 3compartmentss NA 95% Human Human -DTXSID2021363 Css NA 0.1868 mg/L PBTK NA 50% Human Human -DTXSID2021363 Css NA 1.235 mg/L PBTK NA 95% Human Human -DTXSID2021363 Clint NA 2.886 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021363 Fup NA 0.6069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021363 Vd NA 1.148 L/kg 1compartment NA NA Rat Human +DTXSID2021363 TK.Half.Life NA 1.278 hours 1compartment NA NA Human Human +DTXSID2021363 Css NA 0.03016 mg/L 3compartmentss NA 50% Human Human +DTXSID2021363 Css NA 0.3042 mg/L 3compartmentss NA 95% Human Human +DTXSID2021363 Css NA 0.02512 mg/L PBTK NA 50% Human Human +DTXSID2021363 Css NA 0.2183 mg/L PBTK NA 95% Human Human +DTXSID2021363 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021363 Fup 0.519 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021363 Vd NA 1.144 L/kg 1compartment NA NA Rat Human DTXSID2021363 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021363 TK.Half.Life NA 1.412 hours 1compartment NA NA Rat Human -DTXSID2021363 Css NA 0.0996 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021363 Css NA 0.6991 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021363 Css NA 0.08324 mg/L PBTK NA 50% Rat Human -DTXSID2021363 Css NA 0.4331 mg/L PBTK NA 95% Rat Human -DTXSID2021365 Clint NA 5.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021365 Fup NA 0.5964 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021365 Vd NA 1.275 L/kg 1compartment NA NA Human Human +DTXSID2021363 TK.Half.Life NA 0.5436 hours 1compartment NA NA Rat Human +DTXSID2021363 Css NA 0.001075 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021363 Css NA 0.01245 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021363 Css NA 0.0008942 mg/L PBTK NA 50% Rat Human +DTXSID2021363 Css NA 0.008512 mg/L PBTK NA 95% Rat Human +DTXSID2021365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021365 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021365 Vd NA 1.224 L/kg 1compartment NA NA Human Human DTXSID2021365 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021365 TK.Half.Life NA 2.153 hours 1compartment NA NA Human Human -DTXSID2021365 Css NA 0.1338 mg/L 3compartmentss NA 50% Human Human -DTXSID2021365 Css NA 1.139 mg/L 3compartmentss NA 95% Human Human -DTXSID2021365 Css NA 0.1141 mg/L PBTK NA 50% Human Human -DTXSID2021365 Css NA 0.7682 mg/L PBTK NA 95% Human Human -DTXSID2021365 Clint NA 5.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021365 Fup NA 0.5964 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021365 Vd NA 1.136 L/kg 1compartment NA NA Rat Human +DTXSID2021365 TK.Half.Life NA 1.277 hours 1compartment NA NA Human Human +DTXSID2021365 Css NA 0.04271 mg/L 3compartmentss NA 50% Human Human +DTXSID2021365 Css NA 0.374 mg/L 3compartmentss NA 95% Human Human +DTXSID2021365 Css NA 0.03466 mg/L PBTK NA 50% Human Human +DTXSID2021365 Css NA 0.2619 mg/L PBTK NA 95% Human Human +DTXSID2021365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021365 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021365 Vd NA 1.064 L/kg 1compartment NA NA Rat Human DTXSID2021365 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021365 TK.Half.Life NA 0.9972 hours 1compartment NA NA Rat Human -DTXSID2021365 Css NA 0.06384 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021365 Css NA 0.489 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021365 Css NA 0.05335 mg/L PBTK NA 50% Rat Human -DTXSID2021365 Css NA 0.3049 mg/L PBTK NA 95% Rat Human -DTXSID2021367 Clint NA 130.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021367 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021367 Vd NA 2.533 L/kg 1compartment NA NA Human Human +DTXSID2021365 TK.Half.Life NA 0.5514 hours 1compartment NA NA Rat Human +DTXSID2021365 Css NA 0.005392 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021365 Css NA 0.0369 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021365 Css NA 0.004364 mg/L PBTK NA 50% Rat Human +DTXSID2021365 Css NA 0.02581 mg/L PBTK NA 95% Rat Human +DTXSID2021367 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021367 Fup 0.0808 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021367 Vd NA 0.5475 L/kg 1compartment NA NA Human Human DTXSID2021367 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021367 TK.Half.Life NA 2.264 hours 1compartment NA NA Human Human -DTXSID2021367 Css NA 0.01921 mg/L 3compartmentss NA 50% Human Human -DTXSID2021367 Css NA 0.1779 mg/L 3compartmentss NA 95% Human Human -DTXSID2021367 Css NA 0.01386 mg/L PBTK NA 50% Human Human -DTXSID2021367 Css NA 0.1162 mg/L PBTK NA 95% Human Human -DTXSID2021367 Clint NA 130.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021367 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021367 Vd NA 2.09 L/kg 1compartment NA NA Rat Human +DTXSID2021367 TK.Half.Life NA 4.255 hours 1compartment NA NA Human Human +DTXSID2021367 Css NA 1.154 mg/L 3compartmentss NA 50% Human Human +DTXSID2021367 Css NA 7.795 mg/L 3compartmentss NA 95% Human Human +DTXSID2021367 Css NA 0.7312 mg/L PBTK NA 50% Human Human +DTXSID2021367 Css NA 4.734 mg/L PBTK NA 95% Human Human +DTXSID2021367 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021367 Fup 0.0808 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021367 Vd NA 0.5386 L/kg 1compartment NA NA Rat Human DTXSID2021367 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021367 TK.Half.Life NA 0.8231 hours 1compartment NA NA Rat Human -DTXSID2021367 Css NA 0.01078 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021367 Css NA 0.08554 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021367 Css NA 0.007442 mg/L PBTK NA 50% Rat Human -DTXSID2021367 Css NA 0.05327 mg/L PBTK NA 95% Rat Human +DTXSID2021367 TK.Half.Life NA 2.58 hours 1compartment NA NA Rat Human +DTXSID2021367 Css NA 0.142 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021367 Css NA 0.7137 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021367 Css NA 0.08707 mg/L PBTK NA 50% Rat Human +DTXSID2021367 Css NA 0.4171 mg/L PBTK NA 95% Rat Human DTXSID2021440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2021440 Fup 0.953 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2021440 Vd NA 1.719 L/kg 1compartment NA NA Human Human DTXSID2021440 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID2021440 TK.Half.Life NA 11.81 hours 1compartment NA NA Human Human -DTXSID2021440 Css NA 0.691 mg/L 3compartmentss NA 50% Human Human -DTXSID2021440 Css NA 1.982 mg/L 3compartmentss NA 95% Human Human -DTXSID2021440 Css NA 0.6804 mg/L PBTK NA 50% Human Human -DTXSID2021440 Css NA 1.664 mg/L PBTK NA 95% Human Human +DTXSID2021440 Css NA 0.6697 mg/L 3compartmentss NA 50% Human Human +DTXSID2021440 Css NA 1.991 mg/L 3compartmentss NA 95% Human Human +DTXSID2021440 Css NA 0.66 mg/L PBTK NA 50% Human Human +DTXSID2021440 Css NA 1.642 mg/L PBTK NA 95% Human Human DTXSID2021440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2021440 Fup 0.953 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2021440 Vd NA 1.731 L/kg 1compartment NA NA Rat Human DTXSID2021440 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2021440 TK.Half.Life NA 4.016 hours 1compartment NA NA Rat Human -DTXSID2021440 Css NA 0.1745 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021440 Css NA 0.4461 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021440 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID2021440 Css NA 0.3414 mg/L PBTK NA 95% Rat Human -DTXSID2021442 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021442 Fup NA 0.9987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021442 Vd NA 1.438 L/kg 1compartment NA NA Human Human -DTXSID2021442 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021442 TK.Half.Life NA 9.315 hours 1compartment NA NA Human Human -DTXSID2021442 Css NA 0.7431 mg/L 3compartmentss NA 50% Human Human -DTXSID2021442 Css NA 4.588 mg/L 3compartmentss NA 95% Human Human -DTXSID2021442 Css NA 0.711 mg/L PBTK NA 50% Human Human -DTXSID2021442 Css NA 3.27 mg/L PBTK NA 95% Human Human -DTXSID2021442 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021442 Fup NA 0.9987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021442 Vd NA 1.499 L/kg 1compartment NA NA Rat Human +DTXSID2021440 Css NA 0.03958 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021440 Css NA 0.09846 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021440 Css NA 0.04039 mg/L PBTK NA 50% Rat Human +DTXSID2021440 Css NA 0.07851 mg/L PBTK NA 95% Rat Human +DTXSID2021442 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021442 Fup 0.8 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021442 Vd NA 1.267 L/kg 1compartment NA NA Human Human +DTXSID2021442 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2021442 TK.Half.Life NA 10.25 hours 1compartment NA NA Human Human +DTXSID2021442 Css NA 0.7468 mg/L 3compartmentss NA 50% Human Human +DTXSID2021442 Css NA 4.936 mg/L 3compartmentss NA 95% Human Human +DTXSID2021442 Css NA 0.6944 mg/L PBTK NA 50% Human Human +DTXSID2021442 Css NA 3.354 mg/L PBTK NA 95% Human Human +DTXSID2021442 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021442 Fup 0.8 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021442 Vd NA 1.317 L/kg 1compartment NA NA Rat Human DTXSID2021442 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021442 TK.Half.Life NA 3.309 hours 1compartment NA NA Rat Human -DTXSID2021442 Css NA 0.1851 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021442 Css NA 1.222 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021442 Css NA 0.1765 mg/L PBTK NA 50% Rat Human -DTXSID2021442 Css NA 0.7752 mg/L PBTK NA 95% Rat Human -DTXSID2021446 Clint NA 4.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021446 Fup NA 0.2658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021446 Vd NA 2.625 L/kg 1compartment NA NA Human Human -DTXSID2021446 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2021446 TK.Half.Life NA 23.2 hours 1compartment NA NA Human Human -DTXSID2021446 Css NA 0.9691 mg/L 3compartmentss NA 50% Human Human -DTXSID2021446 Css NA 4.776 mg/L 3compartmentss NA 95% Human Human -DTXSID2021446 Css NA 0.7198 mg/L PBTK NA 50% Human Human -DTXSID2021446 Css NA 3.266 mg/L PBTK NA 95% Human Human -DTXSID2021446 Clint NA 4.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021446 Fup NA 0.2658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021446 Vd NA 2.005 L/kg 1compartment NA NA Rat Human -DTXSID2021446 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2021446 TK.Half.Life NA 5.287 hours 1compartment NA NA Rat Human -DTXSID2021446 Css NA 0.49 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021446 Css NA 1.651 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021446 Css NA 0.3482 mg/L PBTK NA 50% Rat Human -DTXSID2021446 Css NA 1.096 mg/L PBTK NA 95% Rat Human -DTXSID2021448 Clint NA 6.578 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021448 Fup NA 0.4234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021448 Vd NA 1.293 L/kg 1compartment NA NA Human Human +DTXSID2021442 TK.Half.Life NA 3.629 hours 1compartment NA NA Rat Human +DTXSID2021442 Css NA 0.01423 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021442 Css NA 0.1163 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021442 Css NA 0.0127 mg/L PBTK NA 50% Rat Human +DTXSID2021442 Css NA 0.08027 mg/L PBTK NA 95% Rat Human +DTXSID2021448 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021448 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021448 Vd NA 1.403 L/kg 1compartment NA NA Human Human DTXSID2021448 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021448 TK.Half.Life NA 2.565 hours 1compartment NA NA Human Human -DTXSID2021448 Css NA 0.1564 mg/L 3compartmentss NA 50% Human Human -DTXSID2021448 Css NA 1.051 mg/L 3compartmentss NA 95% Human Human -DTXSID2021448 Css NA 0.1251 mg/L PBTK NA 50% Human Human -DTXSID2021448 Css NA 0.7433 mg/L PBTK NA 95% Human Human -DTXSID2021448 Clint NA 6.578 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021448 Fup NA 0.4234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021448 Vd NA 1.104 L/kg 1compartment NA NA Rat Human +DTXSID2021448 TK.Half.Life NA 1.601 hours 1compartment NA NA Human Human +DTXSID2021448 Css NA 0.05217 mg/L 3compartmentss NA 50% Human Human +DTXSID2021448 Css NA 0.4177 mg/L 3compartmentss NA 95% Human Human +DTXSID2021448 Css NA 0.04164 mg/L PBTK NA 50% Human Human +DTXSID2021448 Css NA 0.2969 mg/L PBTK NA 95% Human Human +DTXSID2021448 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021448 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021448 Vd NA 1.175 L/kg 1compartment NA NA Rat Human DTXSID2021448 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021448 TK.Half.Life NA 1.141 hours 1compartment NA NA Rat Human -DTXSID2021448 Css NA 0.07883 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021448 Css NA 0.409 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021448 Css NA 0.06137 mg/L PBTK NA 50% Rat Human -DTXSID2021448 Css NA 0.263 mg/L PBTK NA 95% Rat Human -DTXSID2021492 Clint NA 0.2858 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021492 Fup NA 0.7154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021492 Vd NA 1.564 L/kg 1compartment NA NA Human Human -DTXSID2021492 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2021492 TK.Half.Life NA 11.37 hours 1compartment NA NA Human Human -DTXSID2021492 Css NA 0.7174 mg/L 3compartmentss NA 50% Human Human -DTXSID2021492 Css NA 4.373 mg/L 3compartmentss NA 95% Human Human -DTXSID2021492 Css NA 0.6464 mg/L PBTK NA 50% Human Human -DTXSID2021492 Css NA 2.93 mg/L PBTK NA 95% Human Human -DTXSID2021492 Clint NA 0.2858 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021492 Fup NA 0.7154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021492 Vd NA 1.364 L/kg 1compartment NA NA Rat Human -DTXSID2021492 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021492 TK.Half.Life NA 3.558 hours 1compartment NA NA Rat Human -DTXSID2021492 Css NA 0.2248 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021492 Css NA 1.441 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021492 Css NA 0.1986 mg/L PBTK NA 50% Rat Human -DTXSID2021492 Css NA 0.8888 mg/L PBTK NA 95% Rat Human -DTXSID2021498 Clint NA 7.072 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021498 Fup NA 0.1539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021498 Vd NA 2.583 L/kg 1compartment NA NA Human Human -DTXSID2021498 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2021498 TK.Half.Life NA 22.69 hours 1compartment NA NA Human Human -DTXSID2021498 Css NA 1.063 mg/L 3compartmentss NA 50% Human Human -DTXSID2021498 Css NA 5.806 mg/L 3compartmentss NA 95% Human Human -DTXSID2021498 Css NA 0.7504 mg/L PBTK NA 50% Human Human -DTXSID2021498 Css NA 3.896 mg/L PBTK NA 95% Human Human -DTXSID2021498 Clint NA 7.072 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021498 Fup NA 0.1539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021498 Vd NA 1.956 L/kg 1compartment NA NA Rat Human -DTXSID2021498 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2021498 TK.Half.Life NA 5.373 hours 1compartment NA NA Rat Human -DTXSID2021498 Css NA 0.5608 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021498 Css NA 2.261 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021498 Css NA 0.3776 mg/L PBTK NA 50% Rat Human -DTXSID2021498 Css NA 1.443 mg/L PBTK NA 95% Rat Human +DTXSID2021448 TK.Half.Life NA 0.6583 hours 1compartment NA NA Rat Human +DTXSID2021448 Css NA 0.0065 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021448 Css NA 0.03902 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021448 Css NA 0.005194 mg/L PBTK NA 50% Rat Human +DTXSID2021448 Css NA 0.02737 mg/L PBTK NA 95% Rat Human +DTXSID2021498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021498 Fup 0.0631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021498 Vd NA 2.041 L/kg 1compartment NA NA Human Human +DTXSID2021498 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2021498 TK.Half.Life NA 9.546 hours 1compartment NA NA Human Human +DTXSID2021498 Css NA 0.5762 mg/L 3compartmentss NA 50% Human Human +DTXSID2021498 Css NA 4.082 mg/L 3compartmentss NA 95% Human Human +DTXSID2021498 Css NA 0.3822 mg/L PBTK NA 50% Human Human +DTXSID2021498 Css NA 2.581 mg/L PBTK NA 95% Human Human +DTXSID2021498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021498 Fup 0.0631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021498 Vd NA 1.533 L/kg 1compartment NA NA Rat Human +DTXSID2021498 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2021498 TK.Half.Life NA 3.078 hours 1compartment NA NA Rat Human +DTXSID2021498 Css NA 0.07408 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021498 Css NA 0.4239 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021498 Css NA 0.04824 mg/L PBTK NA 50% Rat Human +DTXSID2021498 Css NA 0.2643 mg/L PBTK NA 95% Rat Human DTXSID2021575 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021575 Fup NA 0.3546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021575 Vd NA 0.5322 L/kg 1compartment NA NA Human Human DTXSID2021575 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID2021575 TK.Half.Life NA 9.711 hours 1compartment NA NA Human Human -DTXSID2021575 Css NA 2.066 mg/L 3compartmentss NA 50% Human Human -DTXSID2021575 Css NA 8.362 mg/L 3compartmentss NA 95% Human Human -DTXSID2021575 Css NA 1.513 mg/L PBTK NA 50% Human Human -DTXSID2021575 Css NA 5.372 mg/L PBTK NA 95% Human Human +DTXSID2021575 Css NA 1.719 mg/L 3compartmentss NA 50% Human Human +DTXSID2021575 Css NA 7.256 mg/L 3compartmentss NA 95% Human Human +DTXSID2021575 Css NA 1.266 mg/L PBTK NA 50% Human Human +DTXSID2021575 Css NA 4.657 mg/L PBTK NA 95% Human Human DTXSID2021575 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID2021575 Fup 0.864 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID2021575 Vd NA 0.9216 L/kg 1compartment NA NA Rat Rat DTXSID2021575 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID2021575 TK.Half.Life NA 2.352 hours 1compartment NA NA Rat Rat -DTXSID2021575 Css NA 0.224 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2021575 Css NA 1.368 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2021575 Css NA 0.1941 mg/L PBTK NA 50% Rat Rat -DTXSID2021575 Css NA 0.8421 mg/L PBTK NA 95% Rat Rat +DTXSID2021575 Css NA 0.01413 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2021575 Css NA 0.1111 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2021575 Css NA 0.01207 mg/L PBTK NA 50% Rat Rat +DTXSID2021575 Css NA 0.07363 mg/L PBTK NA 95% Rat Rat DTXSID2021577 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021577 Fup NA 0.876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021577 Vd NA 1.314 L/kg 1compartment NA NA Human Human -DTXSID2021577 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2021577 TK.Half.Life NA 10.43 hours 1compartment NA NA Human Human -DTXSID2021577 Css NA 0.8698 mg/L 3compartmentss NA 50% Human Human -DTXSID2021577 Css NA 5.338 mg/L 3compartmentss NA 95% Human Human -DTXSID2021577 Css NA 0.7942 mg/L PBTK NA 50% Human Human -DTXSID2021577 Css NA 3.558 mg/L PBTK NA 95% Human Human +DTXSID2021577 Vd NA 1.223 L/kg 1compartment NA NA Human Human +DTXSID2021577 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2021577 TK.Half.Life NA 9.524 hours 1compartment NA NA Human Human +DTXSID2021577 Css NA 0.7434 mg/L 3compartmentss NA 50% Human Human +DTXSID2021577 Css NA 4.659 mg/L 3compartmentss NA 95% Human Human +DTXSID2021577 Css NA 0.6741 mg/L PBTK NA 50% Human Human +DTXSID2021577 Css NA 3.112 mg/L PBTK NA 95% Human Human DTXSID2021577 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021577 Fup NA 0.876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021577 Vd NA 1.221 L/kg 1compartment NA NA Rat Human +DTXSID2021577 Vd NA 1.155 L/kg 1compartment NA NA Rat Human DTXSID2021577 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021577 TK.Half.Life NA 3.128 hours 1compartment NA NA Rat Human -DTXSID2021577 Css NA 0.2224 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021577 Css NA 1.377 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021577 Css NA 0.1996 mg/L PBTK NA 50% Rat Human -DTXSID2021577 Css NA 0.8585 mg/L PBTK NA 95% Rat Human -DTXSID2021600 Clint NA 0.1555 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021600 Fup NA 0.2681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021600 Vd NA 0.4821 L/kg 1compartment NA NA Human Human -DTXSID2021600 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021600 TK.Half.Life NA 9.285 hours 1compartment NA NA Human Human -DTXSID2021600 Css NA 2.157 mg/L 3compartmentss NA 50% Human Human -DTXSID2021600 Css NA 8.437 mg/L 3compartmentss NA 95% Human Human -DTXSID2021600 Css NA 1.557 mg/L PBTK NA 50% Human Human -DTXSID2021600 Css NA 5.365 mg/L PBTK NA 95% Human Human -DTXSID2021600 Clint NA 0.1555 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021600 Fup NA 0.2681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021600 Vd NA 0.4733 L/kg 1compartment NA NA Rat Human +DTXSID2021577 TK.Half.Life NA 2.945 hours 1compartment NA NA Rat Human +DTXSID2021577 Css NA 0.01396 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021577 Css NA 0.1044 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021577 Css NA 0.01218 mg/L PBTK NA 50% Rat Human +DTXSID2021577 Css NA 0.07271 mg/L PBTK NA 95% Rat Human +DTXSID2021600 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021600 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021600 Vd NA 0.5609 L/kg 1compartment NA NA Human Human +DTXSID2021600 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2021600 TK.Half.Life NA 10.25 hours 1compartment NA NA Human Human +DTXSID2021600 Css NA 1.936 mg/L 3compartmentss NA 50% Human Human +DTXSID2021600 Css NA 8 mg/L 3compartmentss NA 95% Human Human +DTXSID2021600 Css NA 1.471 mg/L PBTK NA 50% Human Human +DTXSID2021600 Css NA 5.215 mg/L PBTK NA 95% Human Human +DTXSID2021600 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021600 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021600 Vd NA 0.5518 L/kg 1compartment NA NA Rat Human DTXSID2021600 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021600 TK.Half.Life NA 3.464 hours 1compartment NA NA Rat Human -DTXSID2021600 Css NA 0.6728 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021600 Css NA 2.267 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021600 Css NA 0.4592 mg/L PBTK NA 50% Rat Human -DTXSID2021600 Css NA 1.334 mg/L PBTK NA 95% Rat Human -DTXSID2021602 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021602 Fup NA 0.0096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021602 Vd NA 9.535 L/kg 1compartment NA NA Human Human -DTXSID2021602 Days.Css NA 2619 Days PBTK NA NA Human Human -DTXSID2021602 TK.Half.Life NA 9620 hours 1compartment NA NA Human Human -DTXSID2021602 Css NA 89.52 mg/L 3compartmentss NA 50% Human Human -DTXSID2021602 Css NA 663.3 mg/L 3compartmentss NA 95% Human Human -DTXSID2021602 Css NA 98.4 mg/L PBTK NA 50% Human Human -DTXSID2021602 Css NA 468.5 mg/L PBTK NA 95% Human Human -DTXSID2021602 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021602 Fup NA 0.0096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021602 Vd NA 7.507 L/kg 1compartment NA NA Rat Human -DTXSID2021602 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID2021602 TK.Half.Life NA 1929 hours 1compartment NA NA Rat Human -DTXSID2021602 Css NA 23.61 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021602 Css NA 159.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021602 Css NA 25.72 mg/L PBTK NA 50% Rat Human -DTXSID2021602 Css NA 107.1 mg/L PBTK NA 95% Rat Human +DTXSID2021600 TK.Half.Life NA 3.43 hours 1compartment NA NA Rat Human +DTXSID2021600 Css NA 0.1221 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021600 Css NA 0.4414 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021600 Css NA 0.09217 mg/L PBTK NA 50% Rat Human +DTXSID2021600 Css NA 0.2758 mg/L PBTK NA 95% Rat Human +DTXSID2021602 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021602 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021602 Vd NA 11.98 L/kg 1compartment NA NA Human Human +DTXSID2021602 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID2021602 TK.Half.Life NA 131.7 hours 1compartment NA NA Human Human +DTXSID2021602 Css NA 0.8588 mg/L 3compartmentss NA 50% Human Human +DTXSID2021602 Css NA 9.854 mg/L 3compartmentss NA 95% Human Human +DTXSID2021602 Css NA 1.1 mg/L PBTK NA 50% Human Human +DTXSID2021602 Css NA 9.11 mg/L PBTK NA 95% Human Human +DTXSID2021602 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021602 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021602 Vd NA 9.533 L/kg 1compartment NA NA Rat Human +DTXSID2021602 Days.Css NA 14 Days PBTK NA NA Rat Human +DTXSID2021602 TK.Half.Life NA 47.31 hours 1compartment NA NA Rat Human +DTXSID2021602 Css NA 0.1039 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021602 Css NA 0.9876 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021602 Css NA 0.1396 mg/L PBTK NA 50% Rat Human +DTXSID2021602 Css NA 0.9001 mg/L PBTK NA 95% Rat Human +DTXSID20216489 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20216489 Fup 0.028 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20216489 Vd NA 3.027 L/kg 1compartment NA NA Human Human +DTXSID20216489 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID20216489 TK.Half.Life NA 58.39 hours 1compartment NA NA Human Human +DTXSID20216489 Css NA 2.36 mg/L 3compartmentss NA 50% Human Human +DTXSID20216489 Css NA 15.72 mg/L 3compartmentss NA 95% Human Human +DTXSID20216489 Css NA 1.625 mg/L PBTK NA 50% Human Human +DTXSID20216489 Css NA 10.49 mg/L PBTK NA 95% Human Human +DTXSID20216489 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20216489 Fup 0.028 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20216489 Vd NA 2.267 L/kg 1compartment NA NA Rat Human +DTXSID20216489 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID20216489 TK.Half.Life NA 9.021 hours 1compartment NA NA Rat Human +DTXSID20216489 Css NA 0.306 mg/L 3compartmentss NA 50% Rat Human +DTXSID20216489 Css NA 1.692 mg/L 3compartmentss NA 95% Rat Human +DTXSID20216489 Css NA 0.2078 mg/L PBTK NA 50% Rat Human +DTXSID20216489 Css NA 1.112 mg/L PBTK NA 95% Rat Human DTXSID2021650 Clint NA 0.0001303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021650 Fup NA 0.5033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021650 Vd NA 0.5449 L/kg 1compartment NA NA Human Human +DTXSID2021650 Vd NA 0.5423 L/kg 1compartment NA NA Human Human DTXSID2021650 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021650 TK.Half.Life NA 7.002 hours 1compartment NA NA Human Human -DTXSID2021650 Css NA 1.458 mg/L 3compartmentss NA 50% Human Human -DTXSID2021650 Css NA 7.522 mg/L 3compartmentss NA 95% Human Human -DTXSID2021650 Css NA 1.102 mg/L PBTK NA 50% Human Human -DTXSID2021650 Css NA 4.719 mg/L PBTK NA 95% Human Human +DTXSID2021650 TK.Half.Life NA 6.968 hours 1compartment NA NA Human Human +DTXSID2021650 Css NA 1.23 mg/L 3compartmentss NA 50% Human Human +DTXSID2021650 Css NA 6.46 mg/L 3compartmentss NA 95% Human Human +DTXSID2021650 Css NA 0.9382 mg/L PBTK NA 50% Human Human +DTXSID2021650 Css NA 4.055 mg/L PBTK NA 95% Human Human DTXSID2021650 Clint NA 0.0001303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021650 Fup NA 0.5033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021650 Vd NA 0.5644 L/kg 1compartment NA NA Rat Human +DTXSID2021650 Vd NA 0.5619 L/kg 1compartment NA NA Rat Human DTXSID2021650 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021650 TK.Half.Life NA 2.473 hours 1compartment NA NA Rat Human -DTXSID2021650 Css NA 0.3968 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021650 Css NA 1.883 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021650 Css NA 0.2875 mg/L PBTK NA 50% Rat Human -DTXSID2021650 Css NA 1.107 mg/L PBTK NA 95% Rat Human -DTXSID2021652 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021652 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021652 Vd NA 5.794 L/kg 1compartment NA NA Human Human -DTXSID2021652 Days.Css NA 1328 Days PBTK NA NA Human Human -DTXSID2021652 TK.Half.Life NA 4940 hours 1compartment NA NA Human Human -DTXSID2021652 Css NA 94.33 mg/L 3compartmentss NA 50% Human Human -DTXSID2021652 Css NA 571.4 mg/L 3compartmentss NA 95% Human Human -DTXSID2021652 Css NA 81.7 mg/L PBTK NA 50% Human Human -DTXSID2021652 Css NA 380.7 mg/L PBTK NA 95% Human Human -DTXSID2021652 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021652 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021652 Vd NA 4.472 L/kg 1compartment NA NA Rat Human -DTXSID2021652 Days.Css NA 349 Days PBTK NA NA Rat Human -DTXSID2021652 TK.Half.Life NA 910.4 hours 1compartment NA NA Rat Human -DTXSID2021652 Css NA 25.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021652 Css NA 137 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021652 Css NA 21.52 mg/L PBTK NA 50% Rat Human -DTXSID2021652 Css NA 84.26 mg/L PBTK NA 95% Rat Human +DTXSID2021650 TK.Half.Life NA 2.462 hours 1compartment NA NA Rat Human +DTXSID2021650 Css NA 0.02305 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021650 Css NA 0.1595 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021650 Css NA 0.01695 mg/L PBTK NA 50% Rat Human +DTXSID2021650 Css NA 0.1009 mg/L PBTK NA 95% Rat Human +DTXSID2021652 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021652 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021652 Vd NA 4.135 L/kg 1compartment NA NA Human Human +DTXSID2021652 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID2021652 TK.Half.Life NA 45.63 hours 1compartment NA NA Human Human +DTXSID2021652 Css NA 1.403 mg/L 3compartmentss NA 50% Human Human +DTXSID2021652 Css NA 12.81 mg/L 3compartmentss NA 95% Human Human +DTXSID2021652 Css NA 1.077 mg/L PBTK NA 50% Human Human +DTXSID2021652 Css NA 8.914 mg/L PBTK NA 95% Human Human +DTXSID2021652 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021652 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021652 Vd NA 3.154 L/kg 1compartment NA NA Rat Human +DTXSID2021652 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID2021652 TK.Half.Life NA 15.47 hours 1compartment NA NA Rat Human +DTXSID2021652 Css NA 0.18 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021652 Css NA 1.304 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021652 Css NA 0.1366 mg/L PBTK NA 50% Rat Human +DTXSID2021652 Css NA 0.8914 mg/L PBTK NA 95% Rat Human DTXSID2021654 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021654 Fup NA 0.6158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021654 Vd NA 0.6142 L/kg 1compartment NA NA Human Human DTXSID2021654 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2021654 TK.Half.Life NA 6.454 hours 1compartment NA NA Human Human -DTXSID2021654 Css NA 1.212 mg/L 3compartmentss NA 50% Human Human -DTXSID2021654 Css NA 8.153 mg/L 3compartmentss NA 95% Human Human -DTXSID2021654 Css NA 0.9577 mg/L PBTK NA 50% Human Human -DTXSID2021654 Css NA 5.061 mg/L PBTK NA 95% Human Human +DTXSID2021654 Css NA 1.022 mg/L 3compartmentss NA 50% Human Human +DTXSID2021654 Css NA 7.248 mg/L 3compartmentss NA 95% Human Human +DTXSID2021654 Css NA 0.8096 mg/L PBTK NA 50% Human Human +DTXSID2021654 Css NA 4.598 mg/L PBTK NA 95% Human Human DTXSID2021654 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021654 Fup NA 0.6158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021654 Vd NA 0.638 L/kg 1compartment NA NA Rat Human DTXSID2021654 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2021654 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human -DTXSID2021654 Css NA 0.3239 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021654 Css NA 2.031 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021654 Css NA 0.245 mg/L PBTK NA 50% Rat Human -DTXSID2021654 Css NA 1.188 mg/L PBTK NA 95% Rat Human -DTXSID2021656 Clint NA 0.08436 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021656 Fup NA 0.1755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021656 Vd NA 0.3549 L/kg 1compartment NA NA Human Human -DTXSID2021656 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2021656 TK.Half.Life NA 11.47 hours 1compartment NA NA Human Human -DTXSID2021656 Css NA 4.008 mg/L 3compartmentss NA 50% Human Human -DTXSID2021656 Css NA 15.31 mg/L 3compartmentss NA 95% Human Human -DTXSID2021656 Css NA 2.633 mg/L PBTK NA 50% Human Human -DTXSID2021656 Css NA 9.334 mg/L PBTK NA 95% Human Human -DTXSID2021656 Clint NA 0.08436 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021656 Fup NA 0.1755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021656 Vd NA 0.3541 L/kg 1compartment NA NA Rat Human +DTXSID2021654 Css NA 0.01986 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021654 Css NA 0.1677 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021654 Css NA 0.01521 mg/L PBTK NA 50% Rat Human +DTXSID2021654 Css NA 0.1041 mg/L PBTK NA 95% Rat Human +DTXSID20216545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20216545 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20216545 Vd NA 1.569 L/kg 1compartment NA NA Human Human +DTXSID20216545 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20216545 TK.Half.Life NA 2.117 hours 1compartment NA NA Human Human +DTXSID20216545 Css NA 0.07447 mg/L 3compartmentss NA 50% Human Human +DTXSID20216545 Css NA 0.521 mg/L 3compartmentss NA 95% Human Human +DTXSID20216545 Css NA 0.05688 mg/L PBTK NA 50% Human Human +DTXSID20216545 Css NA 0.3664 mg/L PBTK NA 95% Human Human +DTXSID20216545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20216545 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20216545 Vd NA 1.268 L/kg 1compartment NA NA Rat Human +DTXSID20216545 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20216545 TK.Half.Life NA 0.8283 hours 1compartment NA NA Rat Human +DTXSID20216545 Css NA 0.009173 mg/L 3compartmentss NA 50% Rat Human +DTXSID20216545 Css NA 0.05075 mg/L 3compartmentss NA 95% Rat Human +DTXSID20216545 Css NA 0.007042 mg/L PBTK NA 50% Rat Human +DTXSID20216545 Css NA 0.0353 mg/L PBTK NA 95% Rat Human +DTXSID2021656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021656 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021656 Vd NA 0.4995 L/kg 1compartment NA NA Human Human +DTXSID2021656 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2021656 TK.Half.Life NA 0.6006 hours 1compartment NA NA Human Human +DTXSID2021656 Css NA 0.05628 mg/L 3compartmentss NA 50% Human Human +DTXSID2021656 Css NA 0.4177 mg/L 3compartmentss NA 95% Human Human +DTXSID2021656 Css NA 0.04094 mg/L PBTK NA 50% Human Human +DTXSID2021656 Css NA 0.28 mg/L PBTK NA 95% Human Human +DTXSID2021656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021656 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021656 Vd NA 0.501 L/kg 1compartment NA NA Rat Human DTXSID2021656 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021656 TK.Half.Life NA 4.166 hours 1compartment NA NA Rat Human -DTXSID2021656 Css NA 1.228 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021656 Css NA 3.892 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021656 Css NA 0.7607 mg/L PBTK NA 50% Rat Human -DTXSID2021656 Css NA 2.211 mg/L PBTK NA 95% Rat Human +DTXSID2021656 TK.Half.Life NA 0.3154 hours 1compartment NA NA Rat Human +DTXSID2021656 Css NA 0.007077 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021656 Css NA 0.04219 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021656 Css NA 0.005128 mg/L PBTK NA 50% Rat Human +DTXSID2021656 Css NA 0.02784 mg/L PBTK NA 95% Rat Human DTXSID2021731 Clint 0.8866 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID2021731 Fup 0.9449 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID2021731 Vd NA 0.7859 L/kg 1compartment NA NA Human Human DTXSID2021731 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2021731 TK.Half.Life NA 2.345 hours 1compartment NA NA Human Human -DTXSID2021731 Css NA 0.3476 mg/L 3compartmentss NA 50% Human Human -DTXSID2021731 Css NA 1.421 mg/L 3compartmentss NA 95% Human Human -DTXSID2021731 Css NA 0.2894 mg/L PBTK NA 50% Human Human -DTXSID2021731 Css NA 1.018 mg/L PBTK NA 95% Human Human +DTXSID2021731 Css NA 0.3372 mg/L 3compartmentss NA 50% Human Human +DTXSID2021731 Css NA 1.343 mg/L 3compartmentss NA 95% Human Human +DTXSID2021731 Css NA 0.2828 mg/L PBTK NA 50% Human Human +DTXSID2021731 Css NA 0.9771 mg/L PBTK NA 95% Human Human DTXSID2021731 Clint 3.837 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID2021731 Fup 0.9505 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat -DTXSID2021731 Vd NA 0.8202 L/kg 1compartment NA NA Rat Rat +DTXSID2021731 Vd 0.99 0.8202 L/kg 1compartment Horton et al. (1992) NA Rat Rat DTXSID2021731 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID2021731 TK.Half.Life NA 0.5815 hours 1compartment NA NA Rat Rat -DTXSID2021731 Css NA 0.05769 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2021731 Css NA 0.3513 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2021731 Css NA 0.04714 mg/L PBTK NA 50% Rat Rat -DTXSID2021731 Css NA 0.2215 mg/L PBTK NA 95% Rat Rat +DTXSID2021731 TK.Half.Life 2.3 0.5815 hours 1compartment Horton et al. (1992) NA Rat Rat +DTXSID2021731 Css 0.14 0.01312 mg/L 3compartmentss Horton et al. (1992) 50% Rat Rat +DTXSID2021731 Css 0.14 0.08499 mg/L 3compartmentss Horton et al. (1992) 95% Rat Rat +DTXSID2021731 Css 0.14 0.01103 mg/L PBTK Horton et al. (1992) 50% Rat Rat +DTXSID2021731 Css 0.14 0.05461 mg/L PBTK Horton et al. (1992) 95% Rat Rat DTXSID2021735 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021735 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021735 Vd NA 0.7583 L/kg 1compartment NA NA Human Human DTXSID2021735 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2021735 TK.Half.Life NA 4.909 hours 1compartment NA NA Human Human -DTXSID2021735 Css NA 0.8334 mg/L 3compartmentss NA 50% Human Human -DTXSID2021735 Css NA 5.558 mg/L 3compartmentss NA 95% Human Human -DTXSID2021735 Css NA 0.6989 mg/L PBTK NA 50% Human Human -DTXSID2021735 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID2021735 Css NA 0.7018 mg/L 3compartmentss NA 50% Human Human +DTXSID2021735 Css NA 5.049 mg/L 3compartmentss NA 95% Human Human +DTXSID2021735 Css NA 0.5894 mg/L PBTK NA 50% Human Human +DTXSID2021735 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID2021735 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021735 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021735 Vd NA 0.799 L/kg 1compartment NA NA Rat Human DTXSID2021735 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2021735 TK.Half.Life NA 1.762 hours 1compartment NA NA Rat Human -DTXSID2021735 Css NA 0.2092 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021735 Css NA 1.331 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021735 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID2021735 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID2021735 Css NA 0.01288 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021735 Css NA 0.09994 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021735 Css NA 0.0105 mg/L PBTK NA 50% Rat Human +DTXSID2021735 Css NA 0.0655 mg/L PBTK NA 95% Rat Human DTXSID2021739 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021739 Fup NA 0.7342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021739 Vd NA 0.8393 L/kg 1compartment NA NA Human Human DTXSID2021739 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2021739 TK.Half.Life NA 7.466 hours 1compartment NA NA Human Human -DTXSID2021739 Css NA 1.027 mg/L 3compartmentss NA 50% Human Human -DTXSID2021739 Css NA 6.692 mg/L 3compartmentss NA 95% Human Human -DTXSID2021739 Css NA 0.8624 mg/L PBTK NA 50% Human Human -DTXSID2021739 Css NA 4.372 mg/L PBTK NA 95% Human Human +DTXSID2021739 Css NA 0.8731 mg/L 3compartmentss NA 50% Human Human +DTXSID2021739 Css NA 5.763 mg/L 3compartmentss NA 95% Human Human +DTXSID2021739 Css NA 0.7357 mg/L PBTK NA 50% Human Human +DTXSID2021739 Css NA 3.69 mg/L PBTK NA 95% Human Human DTXSID2021739 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021739 Fup NA 0.7342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021739 Vd NA 0.8376 L/kg 1compartment NA NA Rat Human DTXSID2021739 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2021739 TK.Half.Life NA 2.521 hours 1compartment NA NA Rat Human -DTXSID2021739 Css NA 0.2663 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021739 Css NA 1.675 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021739 Css NA 0.2162 mg/L PBTK NA 50% Rat Human -DTXSID2021739 Css NA 1.003 mg/L PBTK NA 95% Rat Human +DTXSID2021739 Css NA 0.01664 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021739 Css NA 0.1404 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021739 Css NA 0.01337 mg/L PBTK NA 50% Rat Human +DTXSID2021739 Css NA 0.09034 mg/L PBTK NA 95% Rat Human DTXSID2021781 Clint 42.5 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID2021781 Fup 0.028 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID2021781 Vd NA 3.299 L/kg 1compartment NA NA Human Human DTXSID2021781 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID2021781 TK.Half.Life NA 26.93 hours 1compartment NA NA Human Human -DTXSID2021781 Css NA 0.7899 mg/L 3compartmentss NA 50% Human Human -DTXSID2021781 Css NA 5.706 mg/L 3compartmentss NA 95% Human Human -DTXSID2021781 Css NA 0.6973 mg/L PBTK NA 50% Human Human -DTXSID2021781 Css NA 4.557 mg/L PBTK NA 95% Human Human +DTXSID2021781 Css NA 0.7728 mg/L 3compartmentss NA 50% Human Human +DTXSID2021781 Css NA 5.77 mg/L 3compartmentss NA 95% Human Human +DTXSID2021781 Css NA 0.6831 mg/L PBTK NA 50% Human Human +DTXSID2021781 Css NA 4.525 mg/L PBTK NA 95% Human Human DTXSID2021781 Clint 42.5 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID2021781 Fup 0.028 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human -DTXSID2021781 Vd NA 2.622 L/kg 1compartment NA NA Rat Human -DTXSID2021781 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2021781 TK.Half.Life NA 5.134 hours 1compartment NA NA Rat Human -DTXSID2021781 Css NA 0.4338 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021781 Css NA 2.461 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021781 Css NA 0.3732 mg/L PBTK NA 50% Rat Human -DTXSID2021781 Css NA 1.982 mg/L PBTK NA 95% Rat Human -DTXSID2021789 Clint NA 58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021789 Fup NA 0.9457 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021789 Vd NA 1.012 L/kg 1compartment NA NA Human Human +DTXSID2021781 Vd 1.1 2.622 L/kg 1compartment National Toxicology Program NA Rat Human +DTXSID2021781 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2021781 TK.Half.Life 0.065 3.089 hours 1compartment National Toxicology Program NA Rat Human +DTXSID2021781 Css 0.0034 0.05223 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID2021781 Css 0.0034 0.3206 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID2021781 Css 0.0034 0.04698 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID2021781 Css 0.0034 0.2631 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID2021789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021789 Fup 0.612 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021789 Vd NA 0.7765 L/kg 1compartment NA NA Human Human DTXSID2021789 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021789 TK.Half.Life NA 0.6027 hours 1compartment NA NA Human Human -DTXSID2021789 Css NA 0.009584 mg/L 3compartmentss NA 50% Human Human -DTXSID2021789 Css NA 0.1013 mg/L 3compartmentss NA 95% Human Human -DTXSID2021789 Css NA 0.008194 mg/L PBTK NA 50% Human Human -DTXSID2021789 Css NA 0.07381 mg/L PBTK NA 95% Human Human -DTXSID2021789 Clint NA 58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021789 Fup NA 0.9457 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021789 Vd NA 1.005 L/kg 1compartment NA NA Rat Human +DTXSID2021789 TK.Half.Life NA 0.6934 hours 1compartment NA NA Human Human +DTXSID2021789 Css NA 0.03303 mg/L 3compartmentss NA 50% Human Human +DTXSID2021789 Css NA 0.3439 mg/L 3compartmentss NA 95% Human Human +DTXSID2021789 Css NA 0.02642 mg/L PBTK NA 50% Human Human +DTXSID2021789 Css NA 0.2366 mg/L PBTK NA 95% Human Human +DTXSID2021789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021789 Fup 0.612 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021789 Vd NA 0.769 L/kg 1compartment NA NA Rat Human DTXSID2021789 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021789 TK.Half.Life NA 0.2707 hours 1compartment NA NA Rat Human -DTXSID2021789 Css NA 0.00482 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021789 Css NA 0.04563 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021789 Css NA 0.004128 mg/L PBTK NA 50% Rat Human -DTXSID2021789 Css NA 0.03325 mg/L PBTK NA 95% Rat Human -DTXSID2021810 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021810 Fup NA 0.4128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021810 Vd NA 1.486 L/kg 1compartment NA NA Human Human +DTXSID2021789 TK.Half.Life NA 0.3401 hours 1compartment NA NA Rat Human +DTXSID2021789 Css NA 0.003954 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021789 Css NA 0.03637 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021789 Css NA 0.003199 mg/L PBTK NA 50% Rat Human +DTXSID2021789 Css NA 0.02392 mg/L PBTK NA 95% Rat Human +DTXSID2021810 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021810 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021810 Vd NA 1.153 L/kg 1compartment NA NA Human Human DTXSID2021810 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021810 TK.Half.Life NA 3.727 hours 1compartment NA NA Human Human -DTXSID2021810 Css NA 0.2154 mg/L 3compartmentss NA 50% Human Human -DTXSID2021810 Css NA 1.338 mg/L 3compartmentss NA 95% Human Human -DTXSID2021810 Css NA 0.1738 mg/L PBTK NA 50% Human Human -DTXSID2021810 Css NA 0.9214 mg/L PBTK NA 95% Human Human -DTXSID2021810 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021810 Fup NA 0.4128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021810 Vd NA 1.235 L/kg 1compartment NA NA Rat Human +DTXSID2021810 TK.Half.Life NA 1.684 hours 1compartment NA NA Human Human +DTXSID2021810 Css NA 0.08438 mg/L 3compartmentss NA 50% Human Human +DTXSID2021810 Css NA 0.6311 mg/L 3compartmentss NA 95% Human Human +DTXSID2021810 Css NA 0.06154 mg/L PBTK NA 50% Human Human +DTXSID2021810 Css NA 0.4288 mg/L PBTK NA 95% Human Human +DTXSID2021810 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021810 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021810 Vd NA 0.9528 L/kg 1compartment NA NA Rat Human DTXSID2021810 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021810 TK.Half.Life NA 1.55 hours 1compartment NA NA Rat Human -DTXSID2021810 Css NA 0.1072 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021810 Css NA 0.5053 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021810 Css NA 0.08302 mg/L PBTK NA 50% Rat Human -DTXSID2021810 Css NA 0.3285 mg/L PBTK NA 95% Rat Human -DTXSID2021864 Clint NA 8.513 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021864 Fup NA 0.3215 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021864 Vd NA 1.784 L/kg 1compartment NA NA Human Human +DTXSID2021810 TK.Half.Life NA 0.7187 hours 1compartment NA NA Rat Human +DTXSID2021810 Css NA 0.01083 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021810 Css NA 0.05892 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021810 Css NA 0.007844 mg/L PBTK NA 50% Rat Human +DTXSID2021810 Css NA 0.03984 mg/L PBTK NA 95% Rat Human +DTXSID2021860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021860 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021860 Vd NA 1.051 L/kg 1compartment NA NA Human Human +DTXSID2021860 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2021860 TK.Half.Life NA 2.078 hours 1compartment NA NA Human Human +DTXSID2021860 Css NA 0.1658 mg/L 3compartmentss NA 50% Human Human +DTXSID2021860 Css NA 1.318 mg/L 3compartmentss NA 95% Human Human +DTXSID2021860 Css NA 0.1118 mg/L PBTK NA 50% Human Human +DTXSID2021860 Css NA 0.8521 mg/L PBTK NA 95% Human Human +DTXSID2021860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021860 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021860 Vd NA 0.8461 L/kg 1compartment NA NA Rat Human +DTXSID2021860 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2021860 TK.Half.Life NA 0.9011 hours 1compartment NA NA Rat Human +DTXSID2021860 Css NA 0.02143 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021860 Css NA 0.1277 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021860 Css NA 0.01427 mg/L PBTK NA 50% Rat Human +DTXSID2021860 Css NA 0.07882 mg/L PBTK NA 95% Rat Human +DTXSID2021864 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021864 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021864 Vd NA 1.588 L/kg 1compartment NA NA Human Human DTXSID2021864 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021864 TK.Half.Life NA 4.289 hours 1compartment NA NA Human Human -DTXSID2021864 Css NA 0.205 mg/L 3compartmentss NA 50% Human Human -DTXSID2021864 Css NA 1.249 mg/L 3compartmentss NA 95% Human Human -DTXSID2021864 Css NA 0.1574 mg/L PBTK NA 50% Human Human -DTXSID2021864 Css NA 0.8777 mg/L PBTK NA 95% Human Human +DTXSID2021864 TK.Half.Life NA 2.509 hours 1compartment NA NA Human Human +DTXSID2021864 Css NA 0.09952 mg/L 3compartmentss NA 50% Human Human +DTXSID2021864 Css NA 0.6699 mg/L 3compartmentss NA 95% Human Human +DTXSID2021864 Css NA 0.07371 mg/L PBTK NA 50% Human Human +DTXSID2021864 Css NA 0.4675 mg/L PBTK NA 95% Human Human DTXSID2021864 Clint 38 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID2021864 Fup 0.228 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID2021864 Vd NA 1.21 L/kg 1compartment NA NA Rat Rat DTXSID2021864 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID2021864 TK.Half.Life NA 0.7482 hours 1compartment NA NA Rat Rat -DTXSID2021864 Css NA 0.03536 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2021864 Css NA 0.1949 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2021864 Css NA 0.02485 mg/L PBTK NA 50% Rat Rat -DTXSID2021864 Css NA 0.1275 mg/L PBTK NA 95% Rat Rat +DTXSID2021864 Css NA 0.00784 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2021864 Css NA 0.04502 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2021864 Css NA 0.005668 mg/L PBTK NA 50% Rat Rat +DTXSID2021864 Css NA 0.03006 mg/L PBTK NA 95% Rat Rat DTXSID2021866 Clint 14.03 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID2021866 Fup 0.5872 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID2021866 Vd NA 3.123 L/kg 1compartment NA NA Human Human -DTXSID2021866 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2021866 TK.Half.Life NA 29.3 hours 1compartment NA NA Human Human -DTXSID2021866 Css NA 1.04 mg/L 3compartmentss NA 50% Human Human -DTXSID2021866 Css NA 6.368 mg/L 3compartmentss NA 95% Human Human -DTXSID2021866 Css NA 0.7446 mg/L PBTK NA 50% Human Human -DTXSID2021866 Css NA 4.377 mg/L PBTK NA 95% Human Human +DTXSID2021866 Vd NA 3.132 L/kg 1compartment NA NA Human Human +DTXSID2021866 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2021866 TK.Half.Life NA 40.39 hours 1compartment NA NA Human Human +DTXSID2021866 Css NA 1.446 mg/L 3compartmentss NA 50% Human Human +DTXSID2021866 Css NA 9.138 mg/L 3compartmentss NA 95% Human Human +DTXSID2021866 Css NA 1.025 mg/L PBTK NA 50% Human Human +DTXSID2021866 Css NA 6.148 mg/L PBTK NA 95% Human Human DTXSID2021866 Clint 14.03 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID2021866 Fup 0.5872 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID2021866 Vd NA 2.356 L/kg 1compartment NA NA Rat Human -DTXSID2021866 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2021866 TK.Half.Life NA 4.359 hours 1compartment NA NA Rat Human -DTXSID2021866 Css NA 0.5766 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021866 Css NA 2.767 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021866 Css NA 0.3948 mg/L PBTK NA 50% Rat Human -DTXSID2021866 Css NA 1.81 mg/L PBTK NA 95% Rat Human -DTXSID2021941 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021941 Fup NA 0.9175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021941 Vd NA 0.7946 L/kg 1compartment NA NA Human Human +DTXSID2021866 Vd NA 2.358 L/kg 1compartment NA NA Rat Human +DTXSID2021866 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2021866 TK.Half.Life NA 5.7 hours 1compartment NA NA Rat Human +DTXSID2021866 Css NA 0.1834 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021866 Css NA 0.8674 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021866 Css NA 0.1294 mg/L PBTK NA 50% Rat Human +DTXSID2021866 Css NA 0.5931 mg/L PBTK NA 95% Rat Human +DTXSID2021941 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021941 Fup 0.633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021941 Vd NA 0.6369 L/kg 1compartment NA NA Human Human DTXSID2021941 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021941 TK.Half.Life NA 5.613 hours 1compartment NA NA Human Human -DTXSID2021941 Css NA 0.8753 mg/L 3compartmentss NA 50% Human Human -DTXSID2021941 Css NA 3.247 mg/L 3compartmentss NA 95% Human Human -DTXSID2021941 Css NA 0.7328 mg/L PBTK NA 50% Human Human -DTXSID2021941 Css NA 2.279 mg/L PBTK NA 95% Human Human -DTXSID2021941 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021941 Fup NA 0.9175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021941 Vd NA 0.8213 L/kg 1compartment NA NA Rat Human +DTXSID2021941 TK.Half.Life NA 6.521 hours 1compartment NA NA Human Human +DTXSID2021941 Css NA 1.011 mg/L 3compartmentss NA 50% Human Human +DTXSID2021941 Css NA 6.681 mg/L 3compartmentss NA 95% Human Human +DTXSID2021941 Css NA 0.8032 mg/L PBTK NA 50% Human Human +DTXSID2021941 Css NA 4.2 mg/L PBTK NA 95% Human Human +DTXSID2021941 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021941 Fup 0.633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021941 Vd NA 0.6569 L/kg 1compartment NA NA Rat Human DTXSID2021941 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021941 TK.Half.Life NA 1.975 hours 1compartment NA NA Rat Human -DTXSID2021941 Css NA 0.223 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021941 Css NA 0.7768 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021941 Css NA 0.1834 mg/L PBTK NA 50% Rat Human -DTXSID2021941 Css NA 0.5 mg/L PBTK NA 95% Rat Human -DTXSID2021947 Clint NA 36.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021947 Fup NA 0.0334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021947 Vd NA 3.111 L/kg 1compartment NA NA Human Human -DTXSID2021947 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID2021947 TK.Half.Life NA 47.7 hours 1compartment NA NA Human Human -DTXSID2021947 Css NA 1.816 mg/L 3compartmentss NA 50% Human Human -DTXSID2021947 Css NA 12.06 mg/L 3compartmentss NA 95% Human Human -DTXSID2021947 Css NA 1.267 mg/L PBTK NA 50% Human Human -DTXSID2021947 Css NA 8.101 mg/L PBTK NA 95% Human Human -DTXSID2021947 Clint NA 36.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021947 Fup NA 0.0334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021947 Vd NA 2.331 L/kg 1compartment NA NA Rat Human -DTXSID2021947 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2021947 TK.Half.Life NA 6.756 hours 1compartment NA NA Rat Human -DTXSID2021947 Css NA 1.018 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021947 Css NA 5.551 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021947 Css NA 0.6748 mg/L PBTK NA 50% Rat Human -DTXSID2021947 Css NA 3.549 mg/L PBTK NA 95% Rat Human +DTXSID2021941 TK.Half.Life NA 2.289 hours 1compartment NA NA Rat Human +DTXSID2021941 Css NA 0.01933 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021941 Css NA 0.1626 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021941 Css NA 0.0146 mg/L PBTK NA 50% Rat Human +DTXSID2021941 Css NA 0.1022 mg/L PBTK NA 95% Rat Human +DTXSID2021947 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021947 Fup 0.0298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2021947 Vd NA 3.119 L/kg 1compartment NA NA Human Human +DTXSID2021947 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID2021947 TK.Half.Life NA 86.03 hours 1compartment NA NA Human Human +DTXSID2021947 Css NA 1.777 mg/L 3compartmentss NA 50% Human Human +DTXSID2021947 Css NA 12.81 mg/L 3compartmentss NA 95% Human Human +DTXSID2021947 Css NA 1.228 mg/L PBTK NA 50% Human Human +DTXSID2021947 Css NA 8.7 mg/L PBTK NA 95% Human Human +DTXSID2021947 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021947 Fup 0.0298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2021947 Vd NA 2.336 L/kg 1compartment NA NA Rat Human +DTXSID2021947 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID2021947 TK.Half.Life NA 11.62 hours 1compartment NA NA Rat Human +DTXSID2021947 Css NA 0.01963 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021947 Css NA 0.1266 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021947 Css NA 0.01302 mg/L PBTK NA 50% Rat Human +DTXSID2021947 Css NA 0.08243 mg/L PBTK NA 95% Rat Human DTXSID2021949 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021949 Fup NA 0.931 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021949 Vd NA 0.9802 L/kg 1compartment NA NA Human Human DTXSID2021949 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2021949 TK.Half.Life NA 6.897 hours 1compartment NA NA Human Human -DTXSID2021949 Css NA 0.8614 mg/L 3compartmentss NA 50% Human Human -DTXSID2021949 Css NA 4.977 mg/L 3compartmentss NA 95% Human Human -DTXSID2021949 Css NA 0.7538 mg/L PBTK NA 50% Human Human -DTXSID2021949 Css NA 3.364 mg/L PBTK NA 95% Human Human +DTXSID2021949 Css NA 0.7404 mg/L 3compartmentss NA 50% Human Human +DTXSID2021949 Css NA 4.374 mg/L 3compartmentss NA 95% Human Human +DTXSID2021949 Css NA 0.6454 mg/L PBTK NA 50% Human Human +DTXSID2021949 Css NA 2.862 mg/L PBTK NA 95% Human Human DTXSID2021949 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021949 Fup NA 0.931 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021949 Vd NA 0.9772 L/kg 1compartment NA NA Rat Human DTXSID2021949 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2021949 TK.Half.Life NA 2.321 hours 1compartment NA NA Rat Human -DTXSID2021949 Css NA 0.22 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021949 Css NA 1.238 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021949 Css NA 0.1879 mg/L PBTK NA 50% Rat Human -DTXSID2021949 Css NA 0.7643 mg/L PBTK NA 95% Rat Human +DTXSID2021949 Css NA 0.01355 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021949 Css NA 0.09908 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021949 Css NA 0.01146 mg/L PBTK NA 50% Rat Human +DTXSID2021949 Css NA 0.06799 mg/L PBTK NA 95% Rat Human DTXSID2021995 Clint 3.797 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2021995 Fup 0.3559 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2021995 Vd NA 1.737 L/kg 1compartment NA NA Human Human DTXSID2021995 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2021995 TK.Half.Life NA 6.478 hours 1compartment NA NA Human Human -DTXSID2021995 Css NA 0.3517 mg/L 3compartmentss NA 50% Human Human -DTXSID2021995 Css NA 1.97 mg/L 3compartmentss NA 95% Human Human -DTXSID2021995 Css NA 0.2774 mg/L PBTK NA 50% Human Human -DTXSID2021995 Css NA 1.369 mg/L PBTK NA 95% Human Human +DTXSID2021995 Css NA 0.3456 mg/L 3compartmentss NA 50% Human Human +DTXSID2021995 Css NA 1.954 mg/L 3compartmentss NA 95% Human Human +DTXSID2021995 Css NA 0.2727 mg/L PBTK NA 50% Human Human +DTXSID2021995 Css NA 1.366 mg/L PBTK NA 95% Human Human DTXSID2021995 Clint 3.797 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2021995 Fup 0.3559 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2021995 Vd NA 1.411 L/kg 1compartment NA NA Rat Human DTXSID2021995 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2021995 TK.Half.Life NA 2.453 hours 1compartment NA NA Rat Human -DTXSID2021995 Css NA 0.173 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021995 Css NA 0.6865 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021995 Css NA 0.132 mg/L PBTK NA 50% Rat Human -DTXSID2021995 Css NA 0.4484 mg/L PBTK NA 95% Rat Human +DTXSID2021995 Css NA 0.03888 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021995 Css NA 0.1581 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021995 Css NA 0.03083 mg/L PBTK NA 50% Rat Human +DTXSID2021995 Css NA 0.1071 mg/L PBTK NA 95% Rat Human DTXSID2021997 Clint NA 0.6271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2021997 Fup NA 0.8825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2021997 Vd NA 1.645 L/kg 1compartment NA NA Human Human +DTXSID2021997 Vd NA 1.353 L/kg 1compartment NA NA Human Human DTXSID2021997 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2021997 TK.Half.Life NA 6.129 hours 1compartment NA NA Human Human -DTXSID2021997 Css NA 0.393 mg/L 3compartmentss NA 50% Human Human -DTXSID2021997 Css NA 2.614 mg/L 3compartmentss NA 95% Human Human -DTXSID2021997 Css NA 0.38 mg/L PBTK NA 50% Human Human -DTXSID2021997 Css NA 1.804 mg/L PBTK NA 95% Human Human +DTXSID2021997 TK.Half.Life NA 5.034 hours 1compartment NA NA Human Human +DTXSID2021997 Css NA 0.3961 mg/L 3compartmentss NA 50% Human Human +DTXSID2021997 Css NA 2.584 mg/L 3compartmentss NA 95% Human Human +DTXSID2021997 Css NA 0.3704 mg/L PBTK NA 50% Human Human +DTXSID2021997 Css NA 1.749 mg/L PBTK NA 95% Human Human DTXSID2021997 Clint NA 0.6271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2021997 Fup NA 0.8825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2021997 Vd NA 1.661 L/kg 1compartment NA NA Rat Human +DTXSID2021997 Vd NA 1.38 L/kg 1compartment NA NA Rat Human DTXSID2021997 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2021997 TK.Half.Life NA 2.801 hours 1compartment NA NA Rat Human -DTXSID2021997 Css NA 0.133 mg/L 3compartmentss NA 50% Rat Human -DTXSID2021997 Css NA 0.8617 mg/L 3compartmentss NA 95% Rat Human -DTXSID2021997 Css NA 0.1292 mg/L PBTK NA 50% Rat Human -DTXSID2021997 Css NA 0.5519 mg/L PBTK NA 95% Rat Human -DTXSID2022048 Clint NA 6.614 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022048 Fup NA 0.0505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022048 Vd NA 2.228 L/kg 1compartment NA NA Human Human -DTXSID2022048 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2022048 TK.Half.Life NA 37.96 hours 1compartment NA NA Human Human -DTXSID2022048 Css NA 2.461 mg/L 3compartmentss NA 50% Human Human -DTXSID2022048 Css NA 15.2 mg/L 3compartmentss NA 95% Human Human -DTXSID2022048 Css NA 1.633 mg/L PBTK NA 50% Human Human -DTXSID2022048 Css NA 9.437 mg/L PBTK NA 95% Human Human -DTXSID2022048 Clint NA 6.614 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022048 Fup NA 0.0505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022048 Vd NA 1.669 L/kg 1compartment NA NA Rat Human -DTXSID2022048 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2022048 TK.Half.Life NA 10.67 hours 1compartment NA NA Rat Human -DTXSID2022048 Css NA 1.325 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022048 Css NA 5.947 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022048 Css NA 0.8312 mg/L PBTK NA 50% Rat Human -DTXSID2022048 Css NA 3.537 mg/L PBTK NA 95% Rat Human -DTXSID2022090 Clint NA 0.06206 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022090 Fup NA 0.8222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022090 Vd NA 1.68 L/kg 1compartment NA NA Human Human +DTXSID2021997 TK.Half.Life NA 2.324 hours 1compartment NA NA Rat Human +DTXSID2021997 Css NA 0.0313 mg/L 3compartmentss NA 50% Rat Human +DTXSID2021997 Css NA 0.1991 mg/L 3compartmentss NA 95% Rat Human +DTXSID2021997 Css NA 0.03011 mg/L PBTK NA 50% Rat Human +DTXSID2021997 Css NA 0.1311 mg/L PBTK NA 95% Rat Human +DTXSID2022048 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022048 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022048 Vd NA 1.416 L/kg 1compartment NA NA Human Human +DTXSID2022048 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2022048 TK.Half.Life NA 16.23 hours 1compartment NA NA Human Human +DTXSID2022048 Css NA 1.848 mg/L 3compartmentss NA 50% Human Human +DTXSID2022048 Css NA 16.34 mg/L 3compartmentss NA 95% Human Human +DTXSID2022048 Css NA 1.14 mg/L PBTK NA 50% Human Human +DTXSID2022048 Css NA 9.712 mg/L PBTK NA 95% Human Human +DTXSID2022048 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022048 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022048 Vd NA 1.047 L/kg 1compartment NA NA Rat Human +DTXSID2022048 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022048 TK.Half.Life NA 6.406 hours 1compartment NA NA Rat Human +DTXSID2022048 Css NA 0.2447 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022048 Css NA 1.727 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022048 Css NA 0.1465 mg/L PBTK NA 50% Rat Human +DTXSID2022048 Css NA 1.005 mg/L PBTK NA 95% Rat Human +DTXSID2022090 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022090 Fup 0.826 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022090 Vd NA 1.522 L/kg 1compartment NA NA Human Human DTXSID2022090 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2022090 TK.Half.Life NA 12.05 hours 1compartment NA NA Human Human -DTXSID2022090 Css NA 0.7542 mg/L 3compartmentss NA 50% Human Human -DTXSID2022090 Css NA 4.887 mg/L 3compartmentss NA 95% Human Human -DTXSID2022090 Css NA 0.7237 mg/L PBTK NA 50% Human Human -DTXSID2022090 Css NA 3.362 mg/L PBTK NA 95% Human Human -DTXSID2022090 Clint NA 0.06206 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022090 Fup NA 0.8222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022090 Vd NA 1.7 L/kg 1compartment NA NA Rat Human +DTXSID2022090 TK.Half.Life NA 11.95 hours 1compartment NA NA Human Human +DTXSID2022090 Css NA 0.8311 mg/L 3compartmentss NA 50% Human Human +DTXSID2022090 Css NA 5.585 mg/L 3compartmentss NA 95% Human Human +DTXSID2022090 Css NA 0.7795 mg/L PBTK NA 50% Human Human +DTXSID2022090 Css NA 3.689 mg/L PBTK NA 95% Human Human +DTXSID2022090 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022090 Fup 0.826 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022090 Vd NA 1.545 L/kg 1compartment NA NA Rat Human DTXSID2022090 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022090 TK.Half.Life NA 4.348 hours 1compartment NA NA Rat Human -DTXSID2022090 Css NA 0.202 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022090 Css NA 1.393 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022090 Css NA 0.19 mg/L PBTK NA 50% Rat Human -DTXSID2022090 Css NA 0.8735 mg/L PBTK NA 95% Rat Human +DTXSID2022090 TK.Half.Life NA 4.126 hours 1compartment NA NA Rat Human +DTXSID2022090 Css NA 0.04906 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022090 Css NA 0.3163 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022090 Css NA 0.04655 mg/L PBTK NA 50% Rat Human +DTXSID2022090 Css NA 0.205 mg/L PBTK NA 95% Rat Human DTXSID2022121 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2022121 Fup 0.101 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2022121 Vd NA 1.676 L/kg 1compartment NA NA Human Human +DTXSID2022121 Vd NA 1.662 L/kg 1compartment NA NA Human Human DTXSID2022121 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID2022121 TK.Half.Life NA 162.1 hours 1compartment NA NA Human Human -DTXSID2022121 Css NA 11.44 mg/L 3compartmentss NA 50% Human Human -DTXSID2022121 Css NA 34.88 mg/L 3compartmentss NA 95% Human Human -DTXSID2022121 Css NA 7.802 mg/L PBTK NA 50% Human Human -DTXSID2022121 Css NA 21.86 mg/L PBTK NA 95% Human Human +DTXSID2022121 TK.Half.Life NA 159.5 hours 1compartment NA NA Human Human +DTXSID2022121 Css NA 10.99 mg/L 3compartmentss NA 50% Human Human +DTXSID2022121 Css NA 33.05 mg/L 3compartmentss NA 95% Human Human +DTXSID2022121 Css NA 7.502 mg/L PBTK NA 50% Human Human +DTXSID2022121 Css NA 20.89 mg/L PBTK NA 95% Human Human DTXSID2022121 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID2022121 Fup 0.1325 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID2022121 Vd NA 1.429 L/kg 1compartment NA NA Rat Rat +DTXSID2022121 Vd NA 1.418 L/kg 1compartment NA NA Rat Rat DTXSID2022121 Days.Css NA 6 Days PBTK NA NA Rat Rat -DTXSID2022121 TK.Half.Life NA 27.57 hours 1compartment NA NA Rat Rat -DTXSID2022121 Css NA 2.94 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2022121 Css NA 9.571 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2022121 Css NA 1.922 mg/L PBTK NA 50% Rat Rat -DTXSID2022121 Css NA 5.545 mg/L PBTK NA 95% Rat Rat -DTXSID2022123 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022123 Fup NA 0.9582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022123 Vd NA 0.751 L/kg 1compartment NA NA Human Human +DTXSID2022121 TK.Half.Life NA 27.28 hours 1compartment NA NA Rat Rat +DTXSID2022121 Css NA 0.6594 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2022121 Css NA 2.126 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2022121 Css NA 0.4465 mg/L PBTK NA 50% Rat Rat +DTXSID2022121 Css NA 1.276 mg/L PBTK NA 95% Rat Rat +DTXSID2022123 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022123 Fup 0.872 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022123 Vd NA 0.7097 L/kg 1compartment NA NA Human Human DTXSID2022123 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022123 TK.Half.Life NA 5.082 hours 1compartment NA NA Human Human -DTXSID2022123 Css NA 0.8646 mg/L 3compartmentss NA 50% Human Human -DTXSID2022123 Css NA 3.023 mg/L 3compartmentss NA 95% Human Human -DTXSID2022123 Css NA 0.7113 mg/L PBTK NA 50% Human Human -DTXSID2022123 Css NA 2.093 mg/L PBTK NA 95% Human Human -DTXSID2022123 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022123 Fup NA 0.9582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022123 Vd NA 0.7701 L/kg 1compartment NA NA Rat Human +DTXSID2022123 TK.Half.Life NA 5.279 hours 1compartment NA NA Human Human +DTXSID2022123 Css NA 0.8145 mg/L 3compartmentss NA 50% Human Human +DTXSID2022123 Css NA 4.754 mg/L 3compartmentss NA 95% Human Human +DTXSID2022123 Css NA 0.6604 mg/L PBTK NA 50% Human Human +DTXSID2022123 Css NA 3.1 mg/L PBTK NA 95% Human Human +DTXSID2022123 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022123 Fup 0.872 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022123 Vd NA 0.7275 L/kg 1compartment NA NA Rat Human DTXSID2022123 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022123 TK.Half.Life NA 1.773 hours 1compartment NA NA Rat Human -DTXSID2022123 Css NA 0.223 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022123 Css NA 0.7037 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022123 Css NA 0.1788 mg/L PBTK NA 50% Rat Human -DTXSID2022123 Css NA 0.4528 mg/L PBTK NA 95% Rat Human -DTXSID2022127 Clint NA 18.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022127 Fup NA 0.0648 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022127 Vd NA 2.097 L/kg 1compartment NA NA Human Human +DTXSID2022123 TK.Half.Life NA 1.841 hours 1compartment NA NA Rat Human +DTXSID2022123 Css NA 0.01507 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022123 Css NA 0.1147 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022123 Css NA 0.01175 mg/L PBTK NA 50% Rat Human +DTXSID2022123 Css NA 0.07387 mg/L PBTK NA 95% Rat Human +DTXSID2022127 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022127 Fup 0.0249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022127 Vd NA 1.458 L/kg 1compartment NA NA Human Human DTXSID2022127 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022127 TK.Half.Life NA 11.49 hours 1compartment NA NA Human Human -DTXSID2022127 Css NA 0.6994 mg/L 3compartmentss NA 50% Human Human -DTXSID2022127 Css NA 4.641 mg/L 3compartmentss NA 95% Human Human -DTXSID2022127 Css NA 0.4662 mg/L PBTK NA 50% Human Human -DTXSID2022127 Css NA 2.915 mg/L PBTK NA 95% Human Human -DTXSID2022127 Clint NA 18.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022127 Fup NA 0.0648 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022127 Vd NA 1.576 L/kg 1compartment NA NA Rat Human +DTXSID2022127 TK.Half.Life NA 11.38 hours 1compartment NA NA Human Human +DTXSID2022127 Css NA 1.193 mg/L 3compartmentss NA 50% Human Human +DTXSID2022127 Css NA 10.71 mg/L 3compartmentss NA 95% Human Human +DTXSID2022127 Css NA 0.7502 mg/L PBTK NA 50% Human Human +DTXSID2022127 Css NA 6.472 mg/L PBTK NA 95% Human Human +DTXSID2022127 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022127 Fup 0.0249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022127 Vd NA 1.085 L/kg 1compartment NA NA Rat Human DTXSID2022127 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022127 TK.Half.Life NA 3.605 hours 1compartment NA NA Rat Human -DTXSID2022127 Css NA 0.3868 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022127 Css NA 1.97 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022127 Css NA 0.2439 mg/L PBTK NA 50% Rat Human -DTXSID2022127 Css NA 1.197 mg/L PBTK NA 95% Rat Human +DTXSID2022127 TK.Half.Life NA 4.44 hours 1compartment NA NA Rat Human +DTXSID2022127 Css NA 0.1538 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022127 Css NA 1.099 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022127 Css NA 0.09371 mg/L PBTK NA 50% Rat Human +DTXSID2022127 Css NA 0.6459 mg/L PBTK NA 95% Rat Human +DTXSID2022171 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022171 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022171 Vd NA 3.519 L/kg 1compartment NA NA Human Human +DTXSID2022171 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022171 TK.Half.Life NA 2.72 hours 1compartment NA NA Human Human +DTXSID2022171 Css NA 0.02385 mg/L 3compartmentss NA 50% Human Human +DTXSID2022171 Css NA 0.2366 mg/L 3compartmentss NA 95% Human Human +DTXSID2022171 Css NA 0.03166 mg/L PBTK NA 50% Human Human +DTXSID2022171 Css NA 0.2363 mg/L PBTK NA 95% Human Human +DTXSID2022171 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022171 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022171 Vd NA 3.494 L/kg 1compartment NA NA Rat Human +DTXSID2022171 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022171 TK.Half.Life NA 1.492 hours 1compartment NA NA Rat Human +DTXSID2022171 Css NA 0.002956 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022171 Css NA 0.02162 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022171 Css NA 0.004112 mg/L PBTK NA 50% Rat Human +DTXSID2022171 Css NA 0.02191 mg/L PBTK NA 95% Rat Human DTXSID2022254 Clint 32.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2022254 Fup 0.0306 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2022254 Vd NA 2.877 L/kg 1compartment NA NA Human Human DTXSID2022254 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID2022254 TK.Half.Life NA 27.65 hours 1compartment NA NA Human Human -DTXSID2022254 Css NA 1.164 mg/L 3compartmentss NA 50% Human Human -DTXSID2022254 Css NA 7.234 mg/L 3compartmentss NA 95% Human Human -DTXSID2022254 Css NA 0.7968 mg/L PBTK NA 50% Human Human -DTXSID2022254 Css NA 4.751 mg/L PBTK NA 95% Human Human +DTXSID2022254 Css NA 1.126 mg/L 3compartmentss NA 50% Human Human +DTXSID2022254 Css NA 7.351 mg/L 3compartmentss NA 95% Human Human +DTXSID2022254 Css NA 0.77 mg/L PBTK NA 50% Human Human +DTXSID2022254 Css NA 4.84 mg/L PBTK NA 95% Human Human DTXSID2022254 Clint 32.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2022254 Fup 0.0306 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2022254 Vd NA 2.154 L/kg 1compartment NA NA Rat Human DTXSID2022254 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID2022254 TK.Half.Life NA 5.216 hours 1compartment NA NA Rat Human -DTXSID2022254 Css NA 0.6474 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022254 Css NA 3.317 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022254 Css NA 0.4237 mg/L PBTK NA 50% Rat Human -DTXSID2022254 Css NA 2.068 mg/L PBTK NA 95% Rat Human -DTXSID2022256 Clint NA 2.824 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022256 Fup NA 0.074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022256 Vd NA 2.599 L/kg 1compartment NA NA Human Human -DTXSID2022256 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID2022256 TK.Half.Life NA 94.72 hours 1compartment NA NA Human Human -DTXSID2022256 Css NA 4.963 mg/L 3compartmentss NA 50% Human Human -DTXSID2022256 Css NA 23.2 mg/L 3compartmentss NA 95% Human Human -DTXSID2022256 Css NA 3.406 mg/L PBTK NA 50% Human Human -DTXSID2022256 Css NA 15.39 mg/L PBTK NA 95% Human Human -DTXSID2022256 Clint NA 2.824 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022256 Fup NA 0.074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022256 Vd NA 1.953 L/kg 1compartment NA NA Rat Human -DTXSID2022256 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID2022256 TK.Half.Life NA 19.95 hours 1compartment NA NA Rat Human -DTXSID2022256 Css NA 2.503 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022256 Css NA 8.462 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022256 Css NA 1.63 mg/L PBTK NA 50% Rat Human -DTXSID2022256 Css NA 5.195 mg/L PBTK NA 95% Rat Human -DTXSID2022331 Clint NA 15.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022331 Fup NA 0.145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022331 Vd NA 2.485 L/kg 1compartment NA NA Human Human +DTXSID2022254 Css NA 0.1452 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022254 Css NA 0.7998 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022254 Css NA 0.09865 mg/L PBTK NA 50% Rat Human +DTXSID2022254 Css NA 0.5354 mg/L PBTK NA 95% Rat Human +DTXSID2022256 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022256 Fup 0.0224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022256 Vd NA 2.063 L/kg 1compartment NA NA Human Human +DTXSID2022256 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2022256 TK.Half.Life NA 19.9 hours 1compartment NA NA Human Human +DTXSID2022256 Css NA 1.42 mg/L 3compartmentss NA 50% Human Human +DTXSID2022256 Css NA 11.6 mg/L 3compartmentss NA 95% Human Human +DTXSID2022256 Css NA 0.9131 mg/L PBTK NA 50% Human Human +DTXSID2022256 Css NA 7.29 mg/L PBTK NA 95% Human Human +DTXSID2022256 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022256 Fup 0.0224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022256 Vd NA 1.535 L/kg 1compartment NA NA Rat Human +DTXSID2022256 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2022256 TK.Half.Life NA 6.239 hours 1compartment NA NA Rat Human +DTXSID2022256 Css NA 0.1803 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022256 Css NA 1.23 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022256 Css NA 0.1144 mg/L PBTK NA 50% Rat Human +DTXSID2022256 Css NA 0.7348 mg/L PBTK NA 95% Rat Human +DTXSID20222742 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20222742 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20222742 Vd NA 0.9807 L/kg 1compartment NA NA Human Human +DTXSID20222742 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20222742 TK.Half.Life NA 4.395 hours 1compartment NA NA Human Human +DTXSID20222742 Css NA 0.3898 mg/L 3compartmentss NA 50% Human Human +DTXSID20222742 Css NA 2.106 mg/L 3compartmentss NA 95% Human Human +DTXSID20222742 Css NA 0.2885 mg/L PBTK NA 50% Human Human +DTXSID20222742 Css NA 1.409 mg/L PBTK NA 95% Human Human +DTXSID20222742 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20222742 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20222742 Vd NA 0.8608 L/kg 1compartment NA NA Rat Human +DTXSID20222742 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20222742 TK.Half.Life NA 2.081 hours 1compartment NA NA Rat Human +DTXSID20222742 Css NA 0.01593 mg/L 3compartmentss NA 50% Rat Human +DTXSID20222742 Css NA 0.1081 mg/L 3compartmentss NA 95% Rat Human +DTXSID20222742 Css NA 0.01175 mg/L PBTK NA 50% Rat Human +DTXSID20222742 Css NA 0.06993 mg/L PBTK NA 95% Rat Human +DTXSID2022331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022331 Fup 0.0831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022331 Vd NA 2.148 L/kg 1compartment NA NA Human Human DTXSID2022331 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022331 TK.Half.Life NA 10.9 hours 1compartment NA NA Human Human -DTXSID2022331 Css NA 0.4803 mg/L 3compartmentss NA 50% Human Human -DTXSID2022331 Css NA 3.101 mg/L 3compartmentss NA 95% Human Human -DTXSID2022331 Css NA 0.341 mg/L PBTK NA 50% Human Human -DTXSID2022331 Css NA 2.095 mg/L PBTK NA 95% Human Human -DTXSID2022331 Clint NA 15.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022331 Fup NA 0.145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022331 Vd NA 1.882 L/kg 1compartment NA NA Rat Human +DTXSID2022331 TK.Half.Life NA 8.672 hours 1compartment NA NA Human Human +DTXSID2022331 Css NA 0.4673 mg/L 3compartmentss NA 50% Human Human +DTXSID2022331 Css NA 3.222 mg/L 3compartmentss NA 95% Human Human +DTXSID2022331 Css NA 0.3147 mg/L PBTK NA 50% Human Human +DTXSID2022331 Css NA 2.079 mg/L PBTK NA 95% Human Human +DTXSID2022331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022331 Fup 0.0831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022331 Vd NA 1.619 L/kg 1compartment NA NA Rat Human DTXSID2022331 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022331 TK.Half.Life NA 2.894 hours 1compartment NA NA Rat Human -DTXSID2022331 Css NA 0.266 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022331 Css NA 1.308 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022331 Css NA 0.1785 mg/L PBTK NA 50% Rat Human -DTXSID2022331 Css NA 0.8463 mg/L PBTK NA 95% Rat Human +DTXSID2022331 TK.Half.Life NA 2.696 hours 1compartment NA NA Rat Human +DTXSID2022331 Css NA 0.06044 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022331 Css NA 0.3119 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022331 Css NA 0.03996 mg/L PBTK NA 50% Rat Human +DTXSID2022331 Css NA 0.1975 mg/L PBTK NA 95% Rat Human +DTXSID20223355 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20223355 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20223355 Vd NA 2.045 L/kg 1compartment NA NA Human Human +DTXSID20223355 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID20223355 TK.Half.Life NA 12.34 hours 1compartment NA NA Human Human +DTXSID20223355 Css NA 0.5483 mg/L 3compartmentss NA 50% Human Human +DTXSID20223355 Css NA 3.268 mg/L 3compartmentss NA 95% Human Human +DTXSID20223355 Css NA 0.5475 mg/L PBTK NA 50% Human Human +DTXSID20223355 Css NA 3.268 mg/L PBTK NA 95% Human Human +DTXSID20223355 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20223355 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20223355 Vd NA 1.605 L/kg 1compartment NA NA Rat Human +DTXSID20223355 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20223355 TK.Half.Life NA 5.825 hours 1compartment NA NA Rat Human +DTXSID20223355 Css NA 0.07344 mg/L 3compartmentss NA 50% Rat Human +DTXSID20223355 Css NA 0.3474 mg/L 3compartmentss NA 95% Rat Human +DTXSID20223355 Css NA 0.07605 mg/L PBTK NA 50% Rat Human +DTXSID20223355 Css NA 0.3598 mg/L PBTK NA 95% Rat Human DTXSID2022381 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2022381 Fup 0.00772 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2022381 Vd NA 3.148 L/kg 1compartment NA NA Human Human -DTXSID2022381 Days.Css NA 1472 Days PBTK NA NA Human Human -DTXSID2022381 TK.Half.Life NA 5394 hours 1compartment NA NA Human Human -DTXSID2022381 Css NA 1.114 mg/L 3compartmentss NA 50% Human Human -DTXSID2022381 Css NA 9.307 mg/L 3compartmentss NA 95% Human Human -DTXSID2022381 Css NA 1.489 mg/L PBTK NA 50% Human Human -DTXSID2022381 Css NA 9.75 mg/L PBTK NA 95% Human Human +DTXSID2022381 Vd NA 3.106 L/kg 1compartment NA NA Human Human +DTXSID2022381 Days.Css NA 1034 Days PBTK NA NA Human Human +DTXSID2022381 TK.Half.Life NA 3790 hours 1compartment NA NA Human Human +DTXSID2022381 Css NA 0.8089 mg/L 3compartmentss NA 50% Human Human +DTXSID2022381 Css NA 7.707 mg/L 3compartmentss NA 95% Human Human +DTXSID2022381 Css NA 1.331 mg/L PBTK NA 50% Human Human +DTXSID2022381 Css NA 9.082 mg/L PBTK NA 95% Human Human DTXSID2022381 Clint 71.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID2022381 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID2022381 Css NA 0.3064 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2022381 Css NA 2.234 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2022462 Clint NA 8.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022462 Fup NA 0.0606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022462 Vd NA 1.878 L/kg 1compartment NA NA Human Human -DTXSID2022462 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2022462 TK.Half.Life NA 19.43 hours 1compartment NA NA Human Human -DTXSID2022462 Css NA 1.542 mg/L 3compartmentss NA 50% Human Human -DTXSID2022462 Css NA 9.538 mg/L 3compartmentss NA 95% Human Human -DTXSID2022462 Css NA 1.012 mg/L PBTK NA 50% Human Human -DTXSID2022462 Css NA 5.952 mg/L PBTK NA 95% Human Human -DTXSID2022462 Clint NA 8.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022462 Fup NA 0.0606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022462 Vd NA 1.412 L/kg 1compartment NA NA Rat Human +DTXSID2022381 Css NA 0.08206 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2022381 Css NA 0.9651 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2022389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022389 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022389 Vd NA 0.7177 L/kg 1compartment NA NA Human Human +DTXSID2022389 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022389 TK.Half.Life NA 8.229 hours 1compartment NA NA Human Human +DTXSID2022389 Css NA 1.826 mg/L 3compartmentss NA 50% Human Human +DTXSID2022389 Css NA 18.21 mg/L 3compartmentss NA 95% Human Human +DTXSID2022389 Css NA 1.084 mg/L PBTK NA 50% Human Human +DTXSID2022389 Css NA 10.58 mg/L PBTK NA 95% Human Human +DTXSID2022389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022389 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022389 Vd NA 0.5393 L/kg 1compartment NA NA Rat Human +DTXSID2022389 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022389 TK.Half.Life NA 3.866 hours 1compartment NA NA Rat Human +DTXSID2022389 Css NA 0.1474 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022389 Css NA 1.348 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022389 Css NA 0.08513 mg/L PBTK NA 50% Rat Human +DTXSID2022389 Css NA 0.7628 mg/L PBTK NA 95% Rat Human +DTXSID2022462 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022462 Fup 0.0393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022462 Vd NA 1.584 L/kg 1compartment NA NA Human Human +DTXSID2022462 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022462 TK.Half.Life NA 9.051 hours 1compartment NA NA Human Human +DTXSID2022462 Css NA 0.8092 mg/L 3compartmentss NA 50% Human Human +DTXSID2022462 Css NA 6.871 mg/L 3compartmentss NA 95% Human Human +DTXSID2022462 Css NA 0.5154 mg/L PBTK NA 50% Human Human +DTXSID2022462 Css NA 4.193 mg/L PBTK NA 95% Human Human +DTXSID2022462 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022462 Fup 0.0393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022462 Vd NA 1.184 L/kg 1compartment NA NA Rat Human DTXSID2022462 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022462 TK.Half.Life NA 6.502 hours 1compartment NA NA Rat Human -DTXSID2022462 Css NA 0.8225 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022462 Css NA 3.825 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022462 Css NA 0.5087 mg/L PBTK NA 50% Rat Human -DTXSID2022462 Css NA 2.243 mg/L PBTK NA 95% Rat Human -DTXSID2022541 Clint NA 4.143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2022462 TK.Half.Life NA 3.398 hours 1compartment NA NA Rat Human +DTXSID2022462 Css NA 0.1062 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022462 Css NA 0.7189 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022462 Css NA 0.06573 mg/L PBTK NA 50% Rat Human +DTXSID2022462 Css NA 0.4264 mg/L PBTK NA 95% Rat Human +DTXSID2022541 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2022541 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2022541 Vd NA 0.2701 L/kg 1compartment NA NA Human Human -DTXSID2022541 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2022541 TK.Half.Life NA 10.97 hours 1compartment NA NA Human Human -DTXSID2022541 Css NA 7.436 mg/L 3compartmentss NA 50% Human Human -DTXSID2022541 Css NA 60 mg/L 3compartmentss NA 95% Human Human -DTXSID2022541 Css NA 4.408 mg/L PBTK NA 50% Human Human -DTXSID2022541 Css NA 34.2 mg/L PBTK NA 95% Human Human -DTXSID2022541 Clint NA 4.143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2022541 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022541 TK.Half.Life NA 7.663 hours 1compartment NA NA Human Human +DTXSID2022541 Css NA 5.095 mg/L 3compartmentss NA 50% Human Human +DTXSID2022541 Css NA 43 mg/L 3compartmentss NA 95% Human Human +DTXSID2022541 Css NA 3.014 mg/L PBTK NA 50% Human Human +DTXSID2022541 Css NA 25.25 mg/L PBTK NA 95% Human Human +DTXSID2022541 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2022541 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2022541 Vd NA 0.2356 L/kg 1compartment NA NA Rat Human DTXSID2022541 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022541 TK.Half.Life NA 5.869 hours 1compartment NA NA Rat Human -DTXSID2022541 Css NA 3.843 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022541 Css NA 24.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022541 Css NA 2.112 mg/L PBTK NA 50% Rat Human -DTXSID2022541 Css NA 13.13 mg/L PBTK NA 95% Rat Human -DTXSID2022543 Clint NA 0.7383 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022543 Fup NA 0.6578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022543 Vd NA 1.166 L/kg 1compartment NA NA Human Human +DTXSID2022541 TK.Half.Life NA 4.234 hours 1compartment NA NA Rat Human +DTXSID2022541 Css NA 0.6184 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022541 Css NA 4.215 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022541 Css NA 0.3514 mg/L PBTK NA 50% Rat Human +DTXSID2022541 Css NA 2.374 mg/L PBTK NA 95% Rat Human +DTXSID2022543 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022543 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022543 Vd NA 0.8858 L/kg 1compartment NA NA Human Human DTXSID2022543 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022543 TK.Half.Life NA 5.668 hours 1compartment NA NA Human Human -DTXSID2022543 Css NA 0.4903 mg/L 3compartmentss NA 50% Human Human -DTXSID2022543 Css NA 3.613 mg/L 3compartmentss NA 95% Human Human -DTXSID2022543 Css NA 0.4238 mg/L PBTK NA 50% Human Human -DTXSID2022543 Css NA 2.41 mg/L PBTK NA 95% Human Human -DTXSID2022543 Clint NA 0.7383 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022543 Fup NA 0.6578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022543 Vd NA 1.069 L/kg 1compartment NA NA Rat Human +DTXSID2022543 TK.Half.Life NA 0.9692 hours 1compartment NA NA Human Human +DTXSID2022543 Css NA 0.04708 mg/L 3compartmentss NA 50% Human Human +DTXSID2022543 Css NA 0.3734 mg/L 3compartmentss NA 95% Human Human +DTXSID2022543 Css NA 0.0363 mg/L PBTK NA 50% Human Human +DTXSID2022543 Css NA 0.26 mg/L PBTK NA 95% Human Human +DTXSID2022543 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022543 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022543 Vd NA 0.8086 L/kg 1compartment NA NA Rat Human DTXSID2022543 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022543 TK.Half.Life NA 2.307 hours 1compartment NA NA Rat Human -DTXSID2022543 Css NA 0.179 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022543 Css NA 1.236 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022543 Css NA 0.1519 mg/L PBTK NA 50% Rat Human -DTXSID2022543 Css NA 0.7468 mg/L PBTK NA 95% Rat Human +DTXSID2022543 TK.Half.Life NA 0.4513 hours 1compartment NA NA Rat Human +DTXSID2022543 Css NA 0.005809 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022543 Css NA 0.03658 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022543 Css NA 0.004478 mg/L PBTK NA 50% Rat Human +DTXSID2022543 Css NA 0.02445 mg/L PBTK NA 95% Rat Human DTXSID2022549 Clint NA 0.5915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2022549 Fup NA 0.0494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022549 Vd NA 0.3171 L/kg 1compartment NA NA Human Human +DTXSID2022549 Vd NA 0.3592 L/kg 1compartment NA NA Human Human DTXSID2022549 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2022549 TK.Half.Life NA 21.06 hours 1compartment NA NA Human Human -DTXSID2022549 Css NA 10.75 mg/L 3compartmentss NA 50% Human Human -DTXSID2022549 Css NA 60.91 mg/L 3compartmentss NA 95% Human Human -DTXSID2022549 Css NA 6.65 mg/L PBTK NA 50% Human Human -DTXSID2022549 Css NA 35.43 mg/L PBTK NA 95% Human Human +DTXSID2022549 TK.Half.Life NA 23.83 hours 1compartment NA NA Human Human +DTXSID2022549 Css NA 10.37 mg/L 3compartmentss NA 50% Human Human +DTXSID2022549 Css NA 57.11 mg/L 3compartmentss NA 95% Human Human +DTXSID2022549 Css NA 6.473 mg/L PBTK NA 50% Human Human +DTXSID2022549 Css NA 33.64 mg/L PBTK NA 95% Human Human DTXSID2022549 Clint NA 0.5915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2022549 Fup NA 0.0494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022549 Vd NA 0.3098 L/kg 1compartment NA NA Rat Human -DTXSID2022549 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022549 TK.Half.Life NA 9.386 hours 1compartment NA NA Rat Human -DTXSID2022549 Css NA 4.149 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022549 Css NA 18.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022549 Css NA 2.39 mg/L PBTK NA 50% Rat Human -DTXSID2022549 Css NA 10.31 mg/L PBTK NA 95% Rat Human -DTXSID2022593 Clint NA 25.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022593 Fup NA 0.3543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022593 Vd NA 0.9226 L/kg 1compartment NA NA Human Human +DTXSID2022549 Vd NA 0.3494 L/kg 1compartment NA NA Rat Human +DTXSID2022549 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2022549 TK.Half.Life NA 10.57 hours 1compartment NA NA Rat Human +DTXSID2022549 Css NA 0.9246 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022549 Css NA 4.184 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022549 Css NA 0.5591 mg/L PBTK NA 50% Rat Human +DTXSID2022549 Css NA 2.386 mg/L PBTK NA 95% Rat Human +DTXSID2022593 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022593 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022593 Vd NA 0.8308 L/kg 1compartment NA NA Human Human DTXSID2022593 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022593 TK.Half.Life NA 1.028 hours 1compartment NA NA Human Human -DTXSID2022593 Css NA 0.05044 mg/L 3compartmentss NA 50% Human Human -DTXSID2022593 Css NA 0.3717 mg/L 3compartmentss NA 95% Human Human -DTXSID2022593 Css NA 0.03818 mg/L PBTK NA 50% Human Human -DTXSID2022593 Css NA 0.2538 mg/L PBTK NA 95% Human Human -DTXSID2022593 Clint NA 25.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022593 Fup NA 0.3543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022593 Vd NA 0.8196 L/kg 1compartment NA NA Rat Human +DTXSID2022593 TK.Half.Life NA 0.9566 hours 1compartment NA NA Human Human +DTXSID2022593 Css NA 0.05196 mg/L 3compartmentss NA 50% Human Human +DTXSID2022593 Css NA 0.4112 mg/L 3compartmentss NA 95% Human Human +DTXSID2022593 Css NA 0.0391 mg/L PBTK NA 50% Human Human +DTXSID2022593 Css NA 0.278 mg/L PBTK NA 95% Human Human +DTXSID2022593 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022593 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022593 Vd NA 0.7595 L/kg 1compartment NA NA Rat Human DTXSID2022593 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022593 TK.Half.Life NA 0.4633 hours 1compartment NA NA Rat Human -DTXSID2022593 Css NA 0.0269 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022593 Css NA 0.1602 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022593 Css NA 0.01958 mg/L PBTK NA 50% Rat Human -DTXSID2022593 Css NA 0.1052 mg/L PBTK NA 95% Rat Human -DTXSID2022595 Clint NA 15.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022595 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022595 Vd NA 0.2037 L/kg 1compartment NA NA Human Human +DTXSID2022593 TK.Half.Life NA 0.4504 hours 1compartment NA NA Rat Human +DTXSID2022593 Css NA 0.00636 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022593 Css NA 0.04132 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022593 Css NA 0.004848 mg/L PBTK NA 50% Rat Human +DTXSID2022593 Css NA 0.02763 mg/L PBTK NA 95% Rat Human +DTXSID2022595 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022595 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022595 Vd NA 0.531 L/kg 1compartment NA NA Human Human DTXSID2022595 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022595 TK.Half.Life NA 5.115 hours 1compartment NA NA Human Human -DTXSID2022595 Css NA 4.644 mg/L 3compartmentss NA 50% Human Human -DTXSID2022595 Css NA 44.94 mg/L 3compartmentss NA 95% Human Human -DTXSID2022595 Css NA 2.722 mg/L PBTK NA 50% Human Human -DTXSID2022595 Css NA 25.98 mg/L PBTK NA 95% Human Human -DTXSID2022595 Clint NA 15.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022595 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022595 Vd NA 0.199 L/kg 1compartment NA NA Rat Human +DTXSID2022595 TK.Half.Life NA 2.061 hours 1compartment NA NA Human Human +DTXSID2022595 Css NA 0.5042 mg/L 3compartmentss NA 50% Human Human +DTXSID2022595 Css NA 4.232 mg/L 3compartmentss NA 95% Human Human +DTXSID2022595 Css NA 0.3325 mg/L PBTK NA 50% Human Human +DTXSID2022595 Css NA 2.611 mg/L PBTK NA 95% Human Human +DTXSID2022595 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022595 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022595 Vd NA 0.5106 L/kg 1compartment NA NA Rat Human DTXSID2022595 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022595 TK.Half.Life NA 3.323 hours 1compartment NA NA Rat Human -DTXSID2022595 Css NA 2.604 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022595 Css NA 19.85 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022595 Css NA 1.43 mg/L PBTK NA 50% Rat Human -DTXSID2022595 Css NA 10.81 mg/L PBTK NA 95% Rat Human -DTXSID2022624 Clint NA 0.8501 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022624 Fup NA 0.9433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022624 Vd NA 1.824 L/kg 1compartment NA NA Human Human -DTXSID2022624 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022624 TK.Half.Life NA 5.484 hours 1compartment NA NA Human Human -DTXSID2022624 Css NA 0.3148 mg/L 3compartmentss NA 50% Human Human -DTXSID2022624 Css NA 2.182 mg/L 3compartmentss NA 95% Human Human -DTXSID2022624 Css NA 0.3135 mg/L PBTK NA 50% Human Human -DTXSID2022624 Css NA 1.571 mg/L PBTK NA 95% Human Human -DTXSID2022624 Clint NA 0.8501 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022624 Fup NA 0.9433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022624 Vd NA 1.863 L/kg 1compartment NA NA Rat Human +DTXSID2022595 TK.Half.Life NA 1.24 hours 1compartment NA NA Rat Human +DTXSID2022595 Css NA 0.06526 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022595 Css NA 0.4281 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022595 Css NA 0.0422 mg/L PBTK NA 50% Rat Human +DTXSID2022595 Css NA 0.2573 mg/L PBTK NA 95% Rat Human +DTXSID2022597 Clint 32.36 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022597 Fup 0.0976 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022597 Vd NA 2.697 L/kg 1compartment NA NA Human Human +DTXSID2022597 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022597 TK.Half.Life NA 10.66 hours 1compartment NA NA Human Human +DTXSID2022597 Css NA 0.4173 mg/L 3compartmentss NA 50% Human Human +DTXSID2022597 Css NA 2.803 mg/L 3compartmentss NA 95% Human Human +DTXSID2022597 Css NA 0.2888 mg/L PBTK NA 50% Human Human +DTXSID2022597 Css NA 1.844 mg/L PBTK NA 95% Human Human +DTXSID2022597 Clint 32.36 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022597 Fup 0.0976 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022597 Vd NA 2.03 L/kg 1compartment NA NA Rat Human +DTXSID2022597 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022597 TK.Half.Life NA 2.521 hours 1compartment NA NA Rat Human +DTXSID2022597 Css NA 0.05369 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022597 Css NA 0.3013 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022597 Css NA 0.03668 mg/L PBTK NA 50% Rat Human +DTXSID2022597 Css NA 0.1966 mg/L PBTK NA 95% Rat Human +DTXSID2022624 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022624 Fup 0.631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022624 Vd NA 1.283 L/kg 1compartment NA NA Human Human +DTXSID2022624 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2022624 TK.Half.Life NA 13.16 hours 1compartment NA NA Human Human +DTXSID2022624 Css NA 0.5563 mg/L 3compartmentss NA 50% Human Human +DTXSID2022624 Css NA 4.584 mg/L 3compartmentss NA 95% Human Human +DTXSID2022624 Css NA 0.5091 mg/L PBTK NA 50% Human Human +DTXSID2022624 Css NA 2.992 mg/L PBTK NA 95% Human Human +DTXSID2022624 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022624 Fup 0.631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022624 Vd NA 1.312 L/kg 1compartment NA NA Rat Human DTXSID2022624 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022624 TK.Half.Life NA 2.649 hours 1compartment NA NA Rat Human -DTXSID2022624 Css NA 0.1118 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022624 Css NA 0.7409 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022624 Css NA 0.112 mg/L PBTK NA 50% Rat Human -DTXSID2022624 Css NA 0.4847 mg/L PBTK NA 95% Rat Human -DTXSID2022626 Clint NA 7.884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022626 Fup NA 0.1726 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022626 Vd NA 3.144 L/kg 1compartment NA NA Human Human -DTXSID2022626 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID2022626 TK.Half.Life NA 50.45 hours 1compartment NA NA Human Human -DTXSID2022626 Css NA 1.804 mg/L 3compartmentss NA 50% Human Human -DTXSID2022626 Css NA 10.37 mg/L 3compartmentss NA 95% Human Human -DTXSID2022626 Css NA 1.318 mg/L PBTK NA 50% Human Human -DTXSID2022626 Css NA 7.312 mg/L PBTK NA 95% Human Human -DTXSID2022626 Clint NA 7.884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022626 Fup NA 0.1726 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022626 Vd NA 2.421 L/kg 1compartment NA NA Rat Human -DTXSID2022626 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2022626 TK.Half.Life NA 8.424 hours 1compartment NA NA Rat Human -DTXSID2022626 Css NA 0.9668 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022626 Css NA 4.153 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022626 Css NA 0.6816 mg/L PBTK NA 50% Rat Human -DTXSID2022626 Css NA 2.829 mg/L PBTK NA 95% Rat Human +DTXSID2022624 TK.Half.Life NA 4.584 hours 1compartment NA NA Rat Human +DTXSID2022624 Css NA 0.002918 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022624 Css NA 0.0238 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022624 Css NA 0.002574 mg/L PBTK NA 50% Rat Human +DTXSID2022624 Css NA 0.01528 mg/L PBTK NA 95% Rat Human DTXSID2022628 Clint 1.986 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2022628 Fup 0.94 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2022628 Vd NA 8.963 L/kg 1compartment NA NA Human Human DTXSID2022628 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2022628 TK.Half.Life NA 16.98 hours 1compartment NA NA Human Human -DTXSID2022628 Css NA 0.1111 mg/L 3compartmentss NA 50% Human Human -DTXSID2022628 Css NA 0.7776 mg/L 3compartmentss NA 95% Human Human -DTXSID2022628 Css NA 0.1047 mg/L PBTK NA 50% Human Human -DTXSID2022628 Css NA 0.5614 mg/L PBTK NA 95% Human Human +DTXSID2022628 Css NA 0.1114 mg/L 3compartmentss NA 50% Human Human +DTXSID2022628 Css NA 0.6571 mg/L 3compartmentss NA 95% Human Human +DTXSID2022628 Css NA 0.1185 mg/L PBTK NA 50% Human Human +DTXSID2022628 Css NA 0.7025 mg/L PBTK NA 95% Human Human DTXSID2022628 Clint 1.986 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2022628 Fup 0.94 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2022628 Vd NA 9.324 L/kg 1compartment NA NA Rat Human DTXSID2022628 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2022628 TK.Half.Life NA 9.177 hours 1compartment NA NA Rat Human -DTXSID2022628 Css NA 0.0785 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022628 Css NA 0.5002 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022628 Css NA 0.07446 mg/L PBTK NA 50% Rat Human -DTXSID2022628 Css NA 0.3266 mg/L PBTK NA 95% Rat Human -DTXSID2022672 Clint NA 5.495 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022672 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022672 Vd NA 2.388 L/kg 1compartment NA NA Human Human -DTXSID2022672 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID2022672 TK.Half.Life NA 45.04 hours 1compartment NA NA Human Human -DTXSID2022672 Css NA 2.631 mg/L 3compartmentss NA 50% Human Human -DTXSID2022672 Css NA 15.53 mg/L 3compartmentss NA 95% Human Human -DTXSID2022672 Css NA 1.777 mg/L PBTK NA 50% Human Human -DTXSID2022672 Css NA 9.928 mg/L PBTK NA 95% Human Human -DTXSID2022672 Clint NA 5.495 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022672 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022672 Vd NA 1.789 L/kg 1compartment NA NA Rat Human -DTXSID2022672 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2022672 TK.Half.Life NA 11.39 hours 1compartment NA NA Rat Human -DTXSID2022672 Css NA 1.389 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022672 Css NA 5.726 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022672 Css NA 0.8934 mg/L PBTK NA 50% Rat Human -DTXSID2022672 Css NA 3.496 mg/L PBTK NA 95% Rat Human +DTXSID2022628 Css NA 0.001193 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022628 Css NA 0.009275 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022628 Css NA 0.001281 mg/L PBTK NA 50% Rat Human +DTXSID2022628 Css NA 0.01001 mg/L PBTK NA 95% Rat Human +DTXSID2022672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022672 Fup 0.0727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022672 Vd NA 2.448 L/kg 1compartment NA NA Human Human +DTXSID2022672 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022672 TK.Half.Life NA 13.12 hours 1compartment NA NA Human Human +DTXSID2022672 Css NA 0.6409 mg/L 3compartmentss NA 50% Human Human +DTXSID2022672 Css NA 4.152 mg/L 3compartmentss NA 95% Human Human +DTXSID2022672 Css NA 0.4324 mg/L PBTK NA 50% Human Human +DTXSID2022672 Css NA 2.724 mg/L PBTK NA 95% Human Human +DTXSID2022672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022672 Fup 0.0727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022672 Vd NA 1.835 L/kg 1compartment NA NA Rat Human +DTXSID2022672 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022672 TK.Half.Life NA 3.455 hours 1compartment NA NA Rat Human +DTXSID2022672 Css NA 0.08183 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022672 Css NA 0.4458 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022672 Css NA 0.05456 mg/L PBTK NA 50% Rat Human +DTXSID2022672 Css NA 0.2879 mg/L PBTK NA 95% Rat Human DTXSID2022674 Clint 2.142 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2022674 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2022674 Vd NA 3.754 L/kg 1compartment NA NA Human Human DTXSID2022674 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2022674 TK.Half.Life NA 12.89 hours 1compartment NA NA Human Human -DTXSID2022674 Css NA 0.2692 mg/L 3compartmentss NA 50% Human Human -DTXSID2022674 Css NA 1.678 mg/L 3compartmentss NA 95% Human Human -DTXSID2022674 Css NA 0.267 mg/L PBTK NA 50% Human Human -DTXSID2022674 Css NA 1.286 mg/L PBTK NA 95% Human Human +DTXSID2022674 Css NA 0.2566 mg/L 3compartmentss NA 50% Human Human +DTXSID2022674 Css NA 1.356 mg/L 3compartmentss NA 95% Human Human +DTXSID2022674 Css NA 0.2556 mg/L PBTK NA 50% Human Human +DTXSID2022674 Css NA 1.354 mg/L PBTK NA 95% Human Human DTXSID2022674 Clint 2.142 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2022674 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2022674 Vd NA 5.046 L/kg 1compartment NA NA Rat Human DTXSID2022674 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2022674 TK.Half.Life NA 6.802 hours 1compartment NA NA Rat Human -DTXSID2022674 Css NA 0.09113 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022674 Css NA 0.7489 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022674 Css NA 0.08648 mg/L PBTK NA 50% Rat Human -DTXSID2022674 Css NA 0.4646 mg/L PBTK NA 95% Rat Human -DTXSID2022676 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022676 Fup NA 0.9017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022676 Vd NA 1.21 L/kg 1compartment NA NA Human Human +DTXSID2022674 Css NA 0.01941 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022674 Css NA 0.1065 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022674 Css NA 0.0201 mg/L PBTK NA 50% Rat Human +DTXSID2022674 Css NA 0.1103 mg/L PBTK NA 95% Rat Human +DTXSID2022676 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022676 Fup 0.746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022676 Vd NA 0.7981 L/kg 1compartment NA NA Human Human DTXSID2022676 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022676 TK.Half.Life NA 8.775 hours 1compartment NA NA Human Human -DTXSID2022676 Css NA 0.8202 mg/L 3compartmentss NA 50% Human Human -DTXSID2022676 Css NA 3.351 mg/L 3compartmentss NA 95% Human Human -DTXSID2022676 Css NA 0.7398 mg/L PBTK NA 50% Human Human -DTXSID2022676 Css NA 2.424 mg/L PBTK NA 95% Human Human -DTXSID2022676 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022676 Fup NA 0.9017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022676 Vd NA 1.213 L/kg 1compartment NA NA Rat Human +DTXSID2022676 TK.Half.Life NA 6.925 hours 1compartment NA NA Human Human +DTXSID2022676 Css NA 0.887 mg/L 3compartmentss NA 50% Human Human +DTXSID2022676 Css NA 5.408 mg/L 3compartmentss NA 95% Human Human +DTXSID2022676 Css NA 0.7267 mg/L PBTK NA 50% Human Human +DTXSID2022676 Css NA 3.425 mg/L PBTK NA 95% Human Human +DTXSID2022676 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022676 Fup 0.746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022676 Vd NA 0.8256 L/kg 1compartment NA NA Rat Human DTXSID2022676 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022676 TK.Half.Life NA 2.974 hours 1compartment NA NA Rat Human -DTXSID2022676 Css NA 0.2093 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022676 Css NA 0.807 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022676 Css NA 0.186 mg/L PBTK NA 50% Rat Human -DTXSID2022676 Css NA 0.5338 mg/L PBTK NA 95% Rat Human +DTXSID2022676 TK.Half.Life NA 2.441 hours 1compartment NA NA Rat Human +DTXSID2022676 Css NA 0.01666 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022676 Css NA 0.1377 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022676 Css NA 0.01322 mg/L PBTK NA 50% Rat Human +DTXSID2022676 Css NA 0.0877 mg/L PBTK NA 95% Rat Human DTXSID2022678 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2022678 Fup 0.0323 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2022678 Vd NA 1.735 L/kg 1compartment NA NA Human Human -DTXSID2022678 Days.Css NA 139 Days PBTK NA NA Human Human -DTXSID2022678 TK.Half.Life NA 564.5 hours 1compartment NA NA Human Human -DTXSID2022678 Css NA 37.92 mg/L 3compartmentss NA 50% Human Human -DTXSID2022678 Css NA 132.2 mg/L 3compartmentss NA 95% Human Human -DTXSID2022678 Css NA 24.76 mg/L PBTK NA 50% Human Human -DTXSID2022678 Css NA 80.06 mg/L PBTK NA 95% Human Human +DTXSID2022678 Vd NA 0.6477 L/kg 1compartment NA NA Human Human +DTXSID2022678 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID2022678 TK.Half.Life NA 138.2 hours 1compartment NA NA Human Human +DTXSID2022678 Css NA 24.07 mg/L 3compartmentss NA 50% Human Human +DTXSID2022678 Css NA 99.27 mg/L 3compartmentss NA 95% Human Human +DTXSID2022678 Css NA 14.82 mg/L PBTK NA 50% Human Human +DTXSID2022678 Css NA 59.34 mg/L PBTK NA 95% Human Human DTXSID2022678 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2022678 Fup 0.0323 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2022678 Vd NA 1.293 L/kg 1compartment NA NA Rat Human -DTXSID2022678 Days.Css NA 32 Days PBTK NA NA Rat Human -DTXSID2022678 TK.Half.Life NA 101.4 hours 1compartment NA NA Rat Human -DTXSID2022678 Css NA 10.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022678 Css NA 30.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022678 Css NA 6.478 mg/L PBTK NA 50% Rat Human -DTXSID2022678 Css NA 17.31 mg/L PBTK NA 95% Rat Human +DTXSID2022678 Vd NA 0.5016 L/kg 1compartment NA NA Rat Human +DTXSID2022678 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID2022678 TK.Half.Life NA 34.76 hours 1compartment NA NA Rat Human +DTXSID2022678 Css NA 1.561 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022678 Css NA 5.372 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022678 Css NA 0.9308 mg/L PBTK NA 50% Rat Human +DTXSID2022678 Css NA 3.065 mg/L PBTK NA 95% Rat Human DTXSID2022703 Clint 13.24 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2022703 Fup 0.056 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2022703 Vd NA 2.043 L/kg 1compartment NA NA Human Human -DTXSID2022703 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2022703 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2022703 TK.Half.Life NA 14.6 hours 1compartment NA NA Human Human -DTXSID2022703 Css NA 1.084 mg/L 3compartmentss NA 50% Human Human -DTXSID2022703 Css NA 7.354 mg/L 3compartmentss NA 95% Human Human -DTXSID2022703 Css NA 0.65 mg/L PBTK NA 50% Human Human -DTXSID2022703 Css NA 4.356 mg/L PBTK NA 95% Human Human +DTXSID2022703 Css NA 1.058 mg/L 3compartmentss NA 50% Human Human +DTXSID2022703 Css NA 7.293 mg/L 3compartmentss NA 95% Human Human +DTXSID2022703 Css NA 0.6342 mg/L PBTK NA 50% Human Human +DTXSID2022703 Css NA 4.374 mg/L PBTK NA 95% Human Human DTXSID2022703 Clint 13.24 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2022703 Fup 0.056 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2022703 Vd NA 1.61 L/kg 1compartment NA NA Rat Human DTXSID2022703 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2022703 TK.Half.Life NA 5.311 hours 1compartment NA NA Rat Human -DTXSID2022703 Css NA 0.6023 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022703 Css NA 3.057 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022703 Css NA 0.3379 mg/L PBTK NA 50% Rat Human -DTXSID2022703 Css NA 1.696 mg/L PBTK NA 95% Rat Human +DTXSID2022703 Css NA 0.1268 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022703 Css NA 0.659 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022703 Css NA 0.07877 mg/L PBTK NA 50% Rat Human +DTXSID2022703 Css NA 0.4096 mg/L PBTK NA 95% Rat Human +DTXSID2022705 Clint 30.37 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human +DTXSID2022705 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2022705 Vd NA 1.923 L/kg 1compartment NA NA Human Human +DTXSID2022705 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022705 TK.Half.Life NA 3.212 hours 1compartment NA NA Human Human +DTXSID2022705 Css NA 0.143 mg/L 3compartmentss NA 50% Human Human +DTXSID2022705 Css NA 1.662 mg/L 3compartmentss NA 95% Human Human +DTXSID2022705 Css NA 0.1086 mg/L PBTK NA 50% Human Human +DTXSID2022705 Css NA 1.102 mg/L PBTK NA 95% Human Human +DTXSID2022705 Clint 30.37 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human +DTXSID2022705 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2022705 Vd NA 1.854 L/kg 1compartment NA NA Rat Human +DTXSID2022705 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022705 TK.Half.Life NA 1.769 hours 1compartment NA NA Rat Human +DTXSID2022705 Css NA 0.01891 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022705 Css NA 0.1769 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022705 Css NA 0.0142 mg/L PBTK NA 50% Rat Human +DTXSID2022705 Css NA 0.1133 mg/L PBTK NA 95% Rat Human DTXSID2022707 Clint 7.66 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.30.8.892 NA Human Human DTXSID2022707 Fup 0.05 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Human Human DTXSID2022707 Vd NA 0.9839 L/kg 1compartment NA NA Human Human DTXSID2022707 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID2022707 TK.Half.Life NA 9.901 hours 1compartment NA NA Human Human -DTXSID2022707 Css NA 1.376 mg/L 3compartmentss NA 50% Human Human -DTXSID2022707 Css NA 10.59 mg/L 3compartmentss NA 95% Human Human -DTXSID2022707 Css NA 1.029 mg/L PBTK NA 50% Human Human -DTXSID2022707 Css NA 7.039 mg/L PBTK NA 95% Human Human +DTXSID2022707 Css NA 1.236 mg/L 3compartmentss NA 50% Human Human +DTXSID2022707 Css NA 8.673 mg/L 3compartmentss NA 95% Human Human +DTXSID2022707 Css NA 1 mg/L PBTK NA 50% Human Human +DTXSID2022707 Css NA 7.024 mg/L PBTK NA 95% Human Human DTXSID2022707 Clint 7.66 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.30.8.892 NA Rat Human DTXSID2022707 Fup 0.05 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Rat Human DTXSID2022707 Vd NA 0.7521 L/kg 1compartment NA NA Rat Human DTXSID2022707 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2022707 TK.Half.Life NA 4.373 hours 1compartment NA NA Rat Human -DTXSID2022707 Css NA 0.726 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022707 Css NA 4.563 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022707 Css NA 0.5194 mg/L PBTK NA 50% Rat Human -DTXSID2022707 Css NA 2.779 mg/L PBTK NA 95% Rat Human -DTXSID2022751 Clint NA 1.057 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022751 Fup NA 0.1635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022751 Vd NA 0.2583 L/kg 1compartment NA NA Human Human +DTXSID2022707 Css NA 0.1456 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022707 Css NA 0.7698 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022707 Css NA 0.1222 mg/L PBTK NA 50% Rat Human +DTXSID2022707 Css NA 0.6455 mg/L PBTK NA 95% Rat Human +DTXSID2022751 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022751 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022751 Vd NA 0.2798 L/kg 1compartment NA NA Human Human DTXSID2022751 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022751 TK.Half.Life NA 3.811 hours 1compartment NA NA Human Human -DTXSID2022751 Css NA 1.992 mg/L 3compartmentss NA 50% Human Human -DTXSID2022751 Css NA 9.3 mg/L 3compartmentss NA 95% Human Human -DTXSID2022751 Css NA 1.243 mg/L PBTK NA 50% Human Human -DTXSID2022751 Css NA 5.584 mg/L PBTK NA 95% Human Human -DTXSID2022751 Clint NA 1.057 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022751 Fup NA 0.1635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022751 Vd NA 0.2611 L/kg 1compartment NA NA Rat Human +DTXSID2022751 TK.Half.Life NA 8.19 hours 1compartment NA NA Human Human +DTXSID2022751 Css NA 2.022 mg/L 3compartmentss NA 50% Human Human +DTXSID2022751 Css NA 7.828 mg/L 3compartmentss NA 95% Human Human +DTXSID2022751 Css NA 1.282 mg/L PBTK NA 50% Human Human +DTXSID2022751 Css NA 4.741 mg/L PBTK NA 95% Human Human +DTXSID2022751 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022751 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022751 Vd NA 0.2852 L/kg 1compartment NA NA Rat Human DTXSID2022751 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022751 TK.Half.Life NA 1.925 hours 1compartment NA NA Rat Human -DTXSID2022751 Css NA 0.8501 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022751 Css NA 3.003 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022751 Css NA 0.4952 mg/L PBTK NA 50% Rat Human -DTXSID2022751 Css NA 1.664 mg/L PBTK NA 95% Rat Human -DTXSID2022753 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2022751 TK.Half.Life NA 2.845 hours 1compartment NA NA Rat Human +DTXSID2022751 Css NA 0.01094 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022751 Css NA 0.0428 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022751 Css NA 0.006594 mg/L PBTK NA 50% Rat Human +DTXSID2022751 Css NA 0.02432 mg/L PBTK NA 95% Rat Human +DTXSID2022753 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2022753 Fup 0.18 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2022753 Vd NA 0.2468 L/kg 1compartment NA NA Human Human DTXSID2022753 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2022753 TK.Half.Life NA 8.873 hours 1compartment NA NA Human Human -DTXSID2022753 Css NA 4.794 mg/L 3compartmentss NA 50% Human Human -DTXSID2022753 Css NA 17.84 mg/L 3compartmentss NA 95% Human Human -DTXSID2022753 Css NA 2.99 mg/L PBTK NA 50% Human Human -DTXSID2022753 Css NA 10.5 mg/L PBTK NA 95% Human Human -DTXSID2022753 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2022753 Css NA 2.593 mg/L 3compartmentss NA 50% Human Human +DTXSID2022753 Css NA 10.24 mg/L 3compartmentss NA 95% Human Human +DTXSID2022753 Css NA 1.621 mg/L PBTK NA 50% Human Human +DTXSID2022753 Css NA 6.071 mg/L PBTK NA 95% Human Human +DTXSID2022753 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2022753 Fup 0.18 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2022753 Vd NA 0.2352 L/kg 1compartment NA NA Rat Human DTXSID2022753 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2022753 TK.Half.Life NA 3.705 hours 1compartment NA NA Rat Human -DTXSID2022753 Css NA 1.973 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022753 Css NA 7.538 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022753 Css NA 1.128 mg/L PBTK NA 50% Rat Human -DTXSID2022753 Css NA 4.135 mg/L PBTK NA 95% Rat Human +DTXSID2022753 Css NA 0.0207 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022753 Css NA 0.09779 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022753 Css NA 0.01189 mg/L PBTK NA 50% Rat Human +DTXSID2022753 Css NA 0.05407 mg/L PBTK NA 95% Rat Human +DTXSID2022755 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022755 Fup 0.31 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2022755 Vd NA 0.3323 L/kg 1compartment NA NA Human Human +DTXSID2022755 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022755 TK.Half.Life NA 6.936 hours 1compartment NA NA Human Human +DTXSID2022755 Css NA 1.377 mg/L 3compartmentss NA 50% Human Human +DTXSID2022755 Css NA 5.635 mg/L 3compartmentss NA 95% Human Human +DTXSID2022755 Css NA 0.9162 mg/L PBTK NA 50% Human Human +DTXSID2022755 Css NA 3.477 mg/L PBTK NA 95% Human Human +DTXSID2022755 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022755 Fup 0.31 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2022755 Vd NA 0.3372 L/kg 1compartment NA NA Rat Human +DTXSID2022755 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022755 TK.Half.Life NA 2.398 hours 1compartment NA NA Rat Human +DTXSID2022755 Css NA 0.00746 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022755 Css NA 0.03145 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022755 Css NA 0.004704 mg/L PBTK NA 50% Rat Human +DTXSID2022755 Css NA 0.01834 mg/L PBTK NA 95% Rat Human +DTXSID2022757 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022757 Fup 0.18 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2022757 Vd NA 0.3235 L/kg 1compartment NA NA Human Human +DTXSID2022757 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022757 TK.Half.Life NA 1.23 hours 1compartment NA NA Human Human +DTXSID2022757 Css NA 0.2164 mg/L 3compartmentss NA 50% Human Human +DTXSID2022757 Css NA 1.443 mg/L 3compartmentss NA 95% Human Human +DTXSID2022757 Css NA 0.1387 mg/L PBTK NA 50% Human Human +DTXSID2022757 Css NA 0.8902 mg/L PBTK NA 95% Human Human +DTXSID2022757 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022757 Fup 0.18 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2022757 Vd NA 0.3269 L/kg 1compartment NA NA Rat Human +DTXSID2022757 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022757 TK.Half.Life NA 0.7347 hours 1compartment NA NA Rat Human +DTXSID2022757 Css NA 0.002108 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022757 Css NA 0.01214 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022757 Css NA 0.001295 mg/L PBTK NA 50% Rat Human +DTXSID2022757 Css NA 0.007021 mg/L PBTK NA 95% Rat Human DTXSID2022759 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2022759 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2022759 Vd NA 0.2008 L/kg 1compartment NA NA Human Human DTXSID2022759 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2022759 TK.Half.Life NA 3.224 hours 1compartment NA NA Human Human -DTXSID2022759 Css NA 2.717 mg/L 3compartmentss NA 50% Human Human -DTXSID2022759 Css NA 15.45 mg/L 3compartmentss NA 95% Human Human -DTXSID2022759 Css NA 1.615 mg/L PBTK NA 50% Human Human -DTXSID2022759 Css NA 9.012 mg/L PBTK NA 95% Human Human +DTXSID2022759 Css NA 1.431 mg/L 3compartmentss NA 50% Human Human +DTXSID2022759 Css NA 8.775 mg/L 3compartmentss NA 95% Human Human +DTXSID2022759 Css NA 0.8524 mg/L PBTK NA 50% Human Human +DTXSID2022759 Css NA 5.084 mg/L PBTK NA 95% Human Human DTXSID2022759 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2022759 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2022759 Vd NA 0.2025 L/kg 1compartment NA NA Rat Human DTXSID2022759 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2022759 TK.Half.Life NA 1.902 hours 1compartment NA NA Rat Human -DTXSID2022759 Css NA 1.347 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022759 Css NA 5.571 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022759 Css NA 0.7476 mg/L PBTK NA 50% Rat Human -DTXSID2022759 Css NA 3.043 mg/L PBTK NA 95% Rat Human -DTXSID2022880 Clint NA 14.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022880 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022880 Vd NA 2.464 L/kg 1compartment NA NA Human Human -DTXSID2022880 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2022880 TK.Half.Life NA 30.55 hours 1compartment NA NA Human Human -DTXSID2022880 Css NA 1.749 mg/L 3compartmentss NA 50% Human Human -DTXSID2022880 Css NA 11.71 mg/L 3compartmentss NA 95% Human Human -DTXSID2022880 Css NA 1.154 mg/L PBTK NA 50% Human Human -DTXSID2022880 Css NA 7.51 mg/L PBTK NA 95% Human Human -DTXSID2022880 Clint NA 14.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022880 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022880 Vd NA 1.842 L/kg 1compartment NA NA Rat Human +DTXSID2022759 Css NA 0.01399 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022759 Css NA 0.07188 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022759 Css NA 0.007786 mg/L PBTK NA 50% Rat Human +DTXSID2022759 Css NA 0.03925 mg/L PBTK NA 95% Rat Human +DTXSID2022830 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022830 Fup 0.91 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2022830 Vd NA 0.4633 L/kg 1compartment NA NA Human Human +DTXSID2022830 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022830 TK.Half.Life NA 3.294 hours 1compartment NA NA Human Human +DTXSID2022830 Css NA 0.8887 mg/L 3compartmentss NA 50% Human Human +DTXSID2022830 Css NA 4.57 mg/L 3compartmentss NA 95% Human Human +DTXSID2022830 Css NA 0.6568 mg/L PBTK NA 50% Human Human +DTXSID2022830 Css NA 2.853 mg/L PBTK NA 95% Human Human +DTXSID2022830 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022830 Fup 0.91 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2022830 Vd NA 0.4905 L/kg 1compartment NA NA Rat Human +DTXSID2022830 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022830 TK.Half.Life NA 1.188 hours 1compartment NA NA Rat Human +DTXSID2022830 Css NA 0.0226 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022830 Css NA 0.1414 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022830 Css NA 0.01613 mg/L PBTK NA 50% Rat Human +DTXSID2022830 Css NA 0.08771 mg/L PBTK NA 95% Rat Human +DTXSID2022836 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID2022836 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2022836 Vd NA 0.7309 L/kg 1compartment NA NA Human Human +DTXSID2022836 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022836 TK.Half.Life NA 8.764 hours 1compartment NA NA Human Human +DTXSID2022836 Css NA 1.386 mg/L 3compartmentss NA 50% Human Human +DTXSID2022836 Css NA 8.939 mg/L 3compartmentss NA 95% Human Human +DTXSID2022836 Css NA 1.053 mg/L PBTK NA 50% Human Human +DTXSID2022836 Css NA 6.792 mg/L PBTK NA 95% Human Human +DTXSID2022836 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID2022836 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2022836 Vd NA 0.6095 L/kg 1compartment NA NA Rat Human +DTXSID2022836 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022836 TK.Half.Life NA 4.362 hours 1compartment NA NA Rat Human +DTXSID2022836 Css NA 0.0586 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022836 Css NA 0.4228 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022836 Css NA 0.04539 mg/L PBTK NA 50% Rat Human +DTXSID2022836 Css NA 0.33 mg/L PBTK NA 95% Rat Human +DTXSID2022880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022880 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022880 Vd NA 1.782 L/kg 1compartment NA NA Human Human +DTXSID2022880 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2022880 TK.Half.Life NA 25.31 hours 1compartment NA NA Human Human +DTXSID2022880 Css NA 2.226 mg/L 3compartmentss NA 50% Human Human +DTXSID2022880 Css NA 18.55 mg/L 3compartmentss NA 95% Human Human +DTXSID2022880 Css NA 1.404 mg/L PBTK NA 50% Human Human +DTXSID2022880 Css NA 11.37 mg/L PBTK NA 95% Human Human +DTXSID2022880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022880 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022880 Vd NA 1.318 L/kg 1compartment NA NA Rat Human DTXSID2022880 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2022880 TK.Half.Life NA 7.714 hours 1compartment NA NA Rat Human -DTXSID2022880 Css NA 0.9652 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022880 Css NA 4.961 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022880 Css NA 0.6105 mg/L PBTK NA 50% Rat Human -DTXSID2022880 Css NA 3.02 mg/L PBTK NA 95% Rat Human -DTXSID2022888 Clint NA 5.851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022888 Fup NA 0.1044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022888 Vd NA 0.5349 L/kg 1compartment NA NA Human Human +DTXSID2022880 TK.Half.Life NA 8.852 hours 1compartment NA NA Rat Human +DTXSID2022880 Css NA 0.2899 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022880 Css NA 2.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022880 Css NA 0.1777 mg/L PBTK NA 50% Rat Human +DTXSID2022880 Css NA 1.229 mg/L PBTK NA 95% Rat Human +DTXSID2022888 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022888 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022888 Vd NA 0.3032 L/kg 1compartment NA NA Human Human DTXSID2022888 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022888 TK.Half.Life NA 3.455 hours 1compartment NA NA Human Human -DTXSID2022888 Css NA 0.9263 mg/L 3compartmentss NA 50% Human Human -DTXSID2022888 Css NA 6.418 mg/L 3compartmentss NA 95% Human Human -DTXSID2022888 Css NA 0.5963 mg/L PBTK NA 50% Human Human -DTXSID2022888 Css NA 3.886 mg/L PBTK NA 95% Human Human -DTXSID2022888 Clint NA 5.851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022888 Fup NA 0.1044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022888 Vd NA 0.4582 L/kg 1compartment NA NA Rat Human +DTXSID2022888 TK.Half.Life NA 1.433 hours 1compartment NA NA Human Human +DTXSID2022888 Css NA 0.6111 mg/L 3compartmentss NA 50% Human Human +DTXSID2022888 Css NA 4.097 mg/L 3compartmentss NA 95% Human Human +DTXSID2022888 Css NA 0.3823 mg/L PBTK NA 50% Human Human +DTXSID2022888 Css NA 2.493 mg/L PBTK NA 95% Human Human +DTXSID2022888 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022888 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022888 Vd NA 0.2962 L/kg 1compartment NA NA Rat Human DTXSID2022888 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022888 TK.Half.Life NA 1.771 hours 1compartment NA NA Rat Human -DTXSID2022888 Css NA 0.49 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022888 Css NA 2.423 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022888 Css NA 0.2964 mg/L PBTK NA 50% Rat Human -DTXSID2022888 Css NA 1.369 mg/L PBTK NA 95% Rat Human +DTXSID2022888 TK.Half.Life NA 0.8373 hours 1compartment NA NA Rat Human +DTXSID2022888 Css NA 0.07579 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022888 Css NA 0.3702 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022888 Css NA 0.04622 mg/L PBTK NA 50% Rat Human +DTXSID2022888 Css NA 0.2134 mg/L PBTK NA 95% Rat Human +DTXSID2022911 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2022911 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2022911 Vd NA 2.295 L/kg 1compartment NA NA Human Human +DTXSID2022911 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2022911 TK.Half.Life NA 5.344 hours 1compartment NA NA Human Human +DTXSID2022911 Css NA 0.2192 mg/L 3compartmentss NA 50% Human Human +DTXSID2022911 Css NA 1.886 mg/L 3compartmentss NA 95% Human Human +DTXSID2022911 Css NA 0.1714 mg/L PBTK NA 50% Human Human +DTXSID2022911 Css NA 1.326 mg/L PBTK NA 95% Human Human +DTXSID2022911 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2022911 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2022911 Vd NA 2.147 L/kg 1compartment NA NA Rat Human +DTXSID2022911 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2022911 TK.Half.Life NA 2.786 hours 1compartment NA NA Rat Human +DTXSID2022911 Css NA 0.02836 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022911 Css NA 0.1916 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022911 Css NA 0.02194 mg/L PBTK NA 50% Rat Human +DTXSID2022911 Css NA 0.1308 mg/L PBTK NA 95% Rat Human DTXSID2022915 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2022915 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2022915 Vd NA 0.9215 L/kg 1compartment NA NA Human Human +DTXSID2022915 Vd NA 0.7977 L/kg 1compartment NA NA Human Human DTXSID2022915 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022915 TK.Half.Life NA 5.965 hours 1compartment NA NA Human Human -DTXSID2022915 Css NA 0.8124 mg/L 3compartmentss NA 50% Human Human -DTXSID2022915 Css NA 5.505 mg/L 3compartmentss NA 95% Human Human -DTXSID2022915 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID2022915 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID2022915 TK.Half.Life NA 5.161 hours 1compartment NA NA Human Human +DTXSID2022915 Css NA 0.4536 mg/L 3compartmentss NA 50% Human Human +DTXSID2022915 Css NA 3.013 mg/L 3compartmentss NA 95% Human Human +DTXSID2022915 Css NA 0.3817 mg/L PBTK NA 50% Human Human +DTXSID2022915 Css NA 1.998 mg/L PBTK NA 95% Human Human DTXSID2022915 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2022915 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2022915 Vd NA 0.9632 L/kg 1compartment NA NA Rat Human +DTXSID2022915 Vd NA 0.8552 L/kg 1compartment NA NA Rat Human DTXSID2022915 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022915 TK.Half.Life NA 2.124 hours 1compartment NA NA Rat Human -DTXSID2022915 Css NA 0.2034 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022915 Css NA 1.298 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022915 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID2022915 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID2022967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2022915 TK.Half.Life NA 1.886 hours 1compartment NA NA Rat Human +DTXSID2022915 Css NA 0.002268 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022915 Css NA 0.01704 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022915 Css NA 0.001866 mg/L PBTK NA 50% Rat Human +DTXSID2022915 Css NA 0.01062 mg/L PBTK NA 95% Rat Human +DTXSID2022963 Clint 7 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID2022963 Fup 0.44 NA NA Williamson 2020 NA Human Human +DTXSID2022963 Vd NA 3.055 L/kg 1compartment NA NA Human Human +DTXSID2022963 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2022963 TK.Half.Life NA 33.28 hours 1compartment NA NA Human Human +DTXSID2022963 Css NA 1.18 mg/L 3compartmentss NA 50% Human Human +DTXSID2022963 Css NA 6.342 mg/L 3compartmentss NA 95% Human Human +DTXSID2022963 Css NA 0.8589 mg/L PBTK NA 50% Human Human +DTXSID2022963 Css NA 4.456 mg/L PBTK NA 95% Human Human +DTXSID2022963 Clint 7 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID2022963 Fup 0.44 NA NA Williamson 2020 NA Rat Human +DTXSID2022963 Vd NA 2.314 L/kg 1compartment NA NA Rat Human +DTXSID2022963 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2022963 TK.Half.Life NA 5.251 hours 1compartment NA NA Rat Human +DTXSID2022963 Css NA 0.1438 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022963 Css NA 0.6004 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022963 Css NA 0.1044 mg/L PBTK NA 50% Rat Human +DTXSID2022963 Css NA 0.4205 mg/L PBTK NA 95% Rat Human +DTXSID2022967 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2022967 Fup 0.61 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2022967 Vd NA 0.4005 L/kg 1compartment NA NA Human Human +DTXSID2022967 Vd NA 0.4009 L/kg 1compartment NA NA Human Human DTXSID2022967 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2022967 TK.Half.Life NA 4.25 hours 1compartment NA NA Human Human -DTXSID2022967 Css NA 1.368 mg/L 3compartmentss NA 50% Human Human -DTXSID2022967 Css NA 8.882 mg/L 3compartmentss NA 95% Human Human -DTXSID2022967 Css NA 0.9735 mg/L PBTK NA 50% Human Human -DTXSID2022967 Css NA 5.337 mg/L PBTK NA 95% Human Human -DTXSID2022967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2022967 TK.Half.Life NA 4.252 hours 1compartment NA NA Human Human +DTXSID2022967 Css NA 0.7331 mg/L 3compartmentss NA 50% Human Human +DTXSID2022967 Css NA 5.063 mg/L 3compartmentss NA 95% Human Human +DTXSID2022967 Css NA 0.5264 mg/L PBTK NA 50% Human Human +DTXSID2022967 Css NA 3.064 mg/L PBTK NA 95% Human Human +DTXSID2022967 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2022967 Fup 0.61 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2022967 Vd NA 0.418 L/kg 1compartment NA NA Rat Human +DTXSID2022967 Vd NA 0.4183 L/kg 1compartment NA NA Rat Human DTXSID2022967 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2022967 TK.Half.Life NA 1.51 hours 1compartment NA NA Rat Human -DTXSID2022967 Css NA 0.3607 mg/L 3compartmentss NA 50% Rat Human -DTXSID2022967 Css NA 2.094 mg/L 3compartmentss NA 95% Rat Human -DTXSID2022967 Css NA 0.2441 mg/L PBTK NA 50% Rat Human -DTXSID2022967 Css NA 1.19 mg/L PBTK NA 95% Rat Human -DTXSID2023010 Clint NA 4.687 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023010 Fup NA 0.5342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023010 Vd NA 1.37 L/kg 1compartment NA NA Human Human +DTXSID2022967 TK.Half.Life NA 1.512 hours 1compartment NA NA Rat Human +DTXSID2022967 Css NA 0.003934 mg/L 3compartmentss NA 50% Rat Human +DTXSID2022967 Css NA 0.02644 mg/L 3compartmentss NA 95% Rat Human +DTXSID2022967 Css NA 0.002682 mg/L PBTK NA 50% Rat Human +DTXSID2022967 Css NA 0.01535 mg/L PBTK NA 95% Rat Human +DTXSID20230084 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20230084 Fup 0.0428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20230084 Vd NA 0.4558 L/kg 1compartment NA NA Human Human +DTXSID20230084 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20230084 TK.Half.Life NA 2.206 hours 1compartment NA NA Human Human +DTXSID20230084 Css NA 0.6682 mg/L 3compartmentss NA 50% Human Human +DTXSID20230084 Css NA 6.072 mg/L 3compartmentss NA 95% Human Human +DTXSID20230084 Css NA 0.4296 mg/L PBTK NA 50% Human Human +DTXSID20230084 Css NA 3.647 mg/L PBTK NA 95% Human Human +DTXSID20230084 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20230084 Fup 0.0428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20230084 Vd NA 0.4336 L/kg 1compartment NA NA Rat Human +DTXSID20230084 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20230084 TK.Half.Life NA 1.334 hours 1compartment NA NA Rat Human +DTXSID20230084 Css NA 0.07861 mg/L 3compartmentss NA 50% Rat Human +DTXSID20230084 Css NA 0.5773 mg/L 3compartmentss NA 95% Rat Human +DTXSID20230084 Css NA 0.04944 mg/L PBTK NA 50% Rat Human +DTXSID20230084 Css NA 0.3429 mg/L PBTK NA 95% Rat Human +DTXSID2023010 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023010 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023010 Vd NA 1.089 L/kg 1compartment NA NA Human Human DTXSID2023010 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023010 TK.Half.Life NA 2.789 hours 1compartment NA NA Human Human -DTXSID2023010 Css NA 0.168 mg/L 3compartmentss NA 50% Human Human -DTXSID2023010 Css NA 1.212 mg/L 3compartmentss NA 95% Human Human -DTXSID2023010 Css NA 0.1405 mg/L PBTK NA 50% Human Human -DTXSID2023010 Css NA 0.8519 mg/L PBTK NA 95% Human Human -DTXSID2023010 Clint NA 4.687 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023010 Fup NA 0.5342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023010 Vd NA 1.185 L/kg 1compartment NA NA Rat Human +DTXSID2023010 TK.Half.Life NA 1.539 hours 1compartment NA NA Human Human +DTXSID2023010 Css NA 0.08014 mg/L 3compartmentss NA 50% Human Human +DTXSID2023010 Css NA 0.5691 mg/L 3compartmentss NA 95% Human Human +DTXSID2023010 Css NA 0.05871 mg/L PBTK NA 50% Human Human +DTXSID2023010 Css NA 0.387 mg/L PBTK NA 95% Human Human +DTXSID2023010 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023010 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023010 Vd NA 0.9112 L/kg 1compartment NA NA Rat Human DTXSID2023010 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023010 TK.Half.Life NA 1.235 hours 1compartment NA NA Rat Human -DTXSID2023010 Css NA 0.0806 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023010 Css NA 0.5045 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023010 Css NA 0.06598 mg/L PBTK NA 50% Rat Human -DTXSID2023010 Css NA 0.32 mg/L PBTK NA 95% Rat Human -DTXSID2023016 Clint NA 8.533 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023016 Fup NA 0.0912 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023016 Vd NA 1.989 L/kg 1compartment NA NA Human Human -DTXSID2023016 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2023016 TK.Half.Life NA 14.86 hours 1compartment NA NA Human Human -DTXSID2023016 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human -DTXSID2023016 Css NA 6.506 mg/L 3compartmentss NA 95% Human Human -DTXSID2023016 Css NA 0.6778 mg/L PBTK NA 50% Human Human -DTXSID2023016 Css NA 4.154 mg/L PBTK NA 95% Human Human -DTXSID2023016 Clint NA 8.533 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023016 Fup NA 0.0912 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023016 Vd NA 1.504 L/kg 1compartment NA NA Rat Human +DTXSID2023010 TK.Half.Life NA 0.6678 hours 1compartment NA NA Rat Human +DTXSID2023010 Css NA 0.01001 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023010 Css NA 0.05639 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023010 Css NA 0.007294 mg/L PBTK NA 50% Rat Human +DTXSID2023010 Css NA 0.03833 mg/L PBTK NA 95% Rat Human +DTXSID2023016 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023016 Fup 0.0715 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023016 Vd NA 1.821 L/kg 1compartment NA NA Human Human +DTXSID2023016 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023016 TK.Half.Life NA 7.184 hours 1compartment NA NA Human Human +DTXSID2023016 Css NA 0.4514 mg/L 3compartmentss NA 50% Human Human +DTXSID2023016 Css NA 3.158 mg/L 3compartmentss NA 95% Human Human +DTXSID2023016 Css NA 0.3 mg/L PBTK NA 50% Human Human +DTXSID2023016 Css NA 1.999 mg/L PBTK NA 95% Human Human +DTXSID2023016 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023016 Fup 0.0715 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023016 Vd NA 1.373 L/kg 1compartment NA NA Rat Human DTXSID2023016 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023016 TK.Half.Life NA 4.814 hours 1compartment NA NA Rat Human -DTXSID2023016 Css NA 0.5391 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023016 Css NA 2.594 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023016 Css NA 0.344 mg/L PBTK NA 50% Rat Human -DTXSID2023016 Css NA 1.554 mg/L PBTK NA 95% Rat Human +DTXSID2023016 TK.Half.Life NA 2.518 hours 1compartment NA NA Rat Human +DTXSID2023016 Css NA 0.05951 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023016 Css NA 0.3141 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023016 Css NA 0.03851 mg/L PBTK NA 50% Rat Human +DTXSID2023016 Css NA 0.1976 mg/L PBTK NA 95% Rat Human DTXSID2023064 Clint 6.231 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2023064 Fup 0.58 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2023064 Vd NA 1.058 L/kg 1compartment NA NA Human Human DTXSID2023064 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2023064 TK.Half.Life NA 1.54 hours 1compartment NA NA Human Human -DTXSID2023064 Css NA 0.03263 mg/L 3compartmentss NA 50% Human Human -DTXSID2023064 Css NA 0.3078 mg/L 3compartmentss NA 95% Human Human -DTXSID2023064 Css NA 0.03118 mg/L PBTK NA 50% Human Human -DTXSID2023064 Css NA 0.2286 mg/L PBTK NA 95% Human Human +DTXSID2023064 Css NA 0.09312 mg/L 3compartmentss NA 50% Human Human +DTXSID2023064 Css NA 0.7164 mg/L 3compartmentss NA 95% Human Human +DTXSID2023064 Css NA 0.09245 mg/L PBTK NA 50% Human Human +DTXSID2023064 Css NA 0.7153 mg/L PBTK NA 95% Human Human DTXSID2023064 Clint 6.231 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2023064 Fup 0.58 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2023064 Vd NA 0.9957 L/kg 1compartment NA NA Rat Human DTXSID2023064 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2023064 TK.Half.Life NA 0.7887 hours 1compartment NA NA Rat Human -DTXSID2023064 Css NA 0.04976 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023064 Css NA 0.4182 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023064 Css NA 0.04651 mg/L PBTK NA 50% Rat Human -DTXSID2023064 Css NA 0.2683 mg/L PBTK NA 95% Rat Human +DTXSID2023064 Css NA 0.01034 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023064 Css NA 0.06041 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023064 Css NA 0.0107 mg/L PBTK NA 50% Rat Human +DTXSID2023064 Css NA 0.06257 mg/L PBTK NA 95% Rat Human DTXSID2023068 Clint 7.399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2023068 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2023068 Vd NA 2.879 L/kg 1compartment NA NA Human Human DTXSID2023068 Days.Css NA 16 Days PBTK NA NA Human Human DTXSID2023068 TK.Half.Life NA 96.82 hours 1compartment NA NA Human Human -DTXSID2023068 Css NA 0.5163 mg/L 3compartmentss NA 50% Human Human -DTXSID2023068 Css NA 3.006 mg/L 3compartmentss NA 95% Human Human -DTXSID2023068 Css NA 0.3083 mg/L PBTK NA 50% Human Human -DTXSID2023068 Css NA 1.787 mg/L PBTK NA 95% Human Human +DTXSID2023068 Css NA 4.335 mg/L 3compartmentss NA 50% Human Human +DTXSID2023068 Css NA 26.56 mg/L 3compartmentss NA 95% Human Human +DTXSID2023068 Css NA 2.991 mg/L PBTK NA 50% Human Human +DTXSID2023068 Css NA 18.32 mg/L PBTK NA 95% Human Human DTXSID2023068 Clint 7.399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2023068 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2023068 Vd NA 2.157 L/kg 1compartment NA NA Rat Human DTXSID2023068 Days.Css NA 9 Days PBTK NA NA Rat Human DTXSID2023068 TK.Half.Life NA 17.03 hours 1compartment NA NA Rat Human -DTXSID2023068 Css NA 2.89 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023068 Css NA 13.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023068 Css NA 1.61 mg/L PBTK NA 50% Rat Human -DTXSID2023068 Css NA 7.219 mg/L PBTK NA 95% Rat Human -DTXSID2023143 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2023068 Css NA 0.5261 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023068 Css NA 2.516 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023068 Css NA 0.3759 mg/L PBTK NA 50% Rat Human +DTXSID2023068 Css NA 1.798 mg/L PBTK NA 95% Rat Human +DTXSID20230862 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20230862 Fup 0.553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20230862 Vd NA 1.557 L/kg 1compartment NA NA Human Human +DTXSID20230862 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20230862 TK.Half.Life NA 2.247 hours 1compartment NA NA Human Human +DTXSID20230862 Css NA 0.0964 mg/L 3compartmentss NA 50% Human Human +DTXSID20230862 Css NA 0.9353 mg/L 3compartmentss NA 95% Human Human +DTXSID20230862 Css NA 0.08942 mg/L PBTK NA 50% Human Human +DTXSID20230862 Css NA 0.6684 mg/L PBTK NA 95% Human Human +DTXSID20230862 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20230862 Fup 0.553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20230862 Vd NA 1.995 L/kg 1compartment NA NA Rat Human +DTXSID20230862 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20230862 TK.Half.Life NA 1.145 hours 1compartment NA NA Rat Human +DTXSID20230862 Css NA 0.007426 mg/L 3compartmentss NA 50% Rat Human +DTXSID20230862 Css NA 0.06252 mg/L 3compartmentss NA 95% Rat Human +DTXSID20230862 Css NA 0.007914 mg/L PBTK NA 50% Rat Human +DTXSID20230862 Css NA 0.04501 mg/L PBTK NA 95% Rat Human +DTXSID2023143 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2023143 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023143 Vd NA 1.014 L/kg 1compartment NA NA Human Human +DTXSID2023143 Vd NA 0.7122 L/kg 1compartment NA NA Human Human DTXSID2023143 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023143 TK.Half.Life NA 7.787 hours 1compartment NA NA Human Human -DTXSID2023143 Css NA 0.9042 mg/L 3compartmentss NA 50% Human Human -DTXSID2023143 Css NA 5.562 mg/L 3compartmentss NA 95% Human Human -DTXSID2023143 Css NA 0.7919 mg/L PBTK NA 50% Human Human -DTXSID2023143 Css NA 3.68 mg/L PBTK NA 95% Human Human -DTXSID2023143 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2023143 TK.Half.Life NA 5.361 hours 1compartment NA NA Human Human +DTXSID2023143 Css NA 0.5298 mg/L 3compartmentss NA 50% Human Human +DTXSID2023143 Css NA 3.115 mg/L 3compartmentss NA 95% Human Human +DTXSID2023143 Css NA 0.4329 mg/L PBTK NA 50% Human Human +DTXSID2023143 Css NA 2.051 mg/L PBTK NA 95% Human Human +DTXSID2023143 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2023143 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023143 Vd NA 0.9936 L/kg 1compartment NA NA Rat Human +DTXSID2023143 Vd NA 0.7463 L/kg 1compartment NA NA Rat Human DTXSID2023143 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023143 TK.Half.Life NA 2.561 hours 1compartment NA NA Rat Human -DTXSID2023143 Css NA 0.2285 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023143 Css NA 1.391 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023143 Css NA 0.1958 mg/L PBTK NA 50% Rat Human -DTXSID2023143 Css NA 0.8523 mg/L PBTK NA 95% Rat Human +DTXSID2023143 TK.Half.Life NA 1.914 hours 1compartment NA NA Rat Human +DTXSID2023143 Css NA 0.002718 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023143 Css NA 0.01774 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023143 Css NA 0.002161 mg/L PBTK NA 50% Rat Human +DTXSID2023143 Css NA 0.01091 mg/L PBTK NA 95% Rat Human DTXSID2023145 Clint NA 12.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2023145 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023145 Vd NA 0.5412 L/kg 1compartment NA NA Human Human +DTXSID2023145 Vd NA 0.2142 L/kg 1compartment NA NA Human Human DTXSID2023145 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023145 TK.Half.Life NA 3.601 hours 1compartment NA NA Human Human -DTXSID2023145 Css NA 0.9952 mg/L 3compartmentss NA 50% Human Human -DTXSID2023145 Css NA 8.176 mg/L 3compartmentss NA 95% Human Human -DTXSID2023145 Css NA 0.6528 mg/L PBTK NA 50% Human Human -DTXSID2023145 Css NA 4.939 mg/L PBTK NA 95% Human Human +DTXSID2023145 TK.Half.Life NA 1.344 hours 1compartment NA NA Human Human +DTXSID2023145 Css NA 0.5234 mg/L 3compartmentss NA 50% Human Human +DTXSID2023145 Css NA 4.632 mg/L 3compartmentss NA 95% Human Human +DTXSID2023145 Css NA 0.3114 mg/L PBTK NA 50% Human Human +DTXSID2023145 Css NA 2.678 mg/L PBTK NA 95% Human Human DTXSID2023145 Clint NA 12.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2023145 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023145 Vd NA 0.5166 L/kg 1compartment NA NA Rat Human +DTXSID2023145 Vd NA 0.2161 L/kg 1compartment NA NA Rat Human DTXSID2023145 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023145 TK.Half.Life NA 2.186 hours 1compartment NA NA Rat Human -DTXSID2023145 Css NA 0.5434 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023145 Css NA 3.549 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023145 Css NA 0.3366 mg/L PBTK NA 50% Rat Human -DTXSID2023145 Css NA 2.035 mg/L PBTK NA 95% Rat Human +DTXSID2023145 TK.Half.Life NA 0.8608 hours 1compartment NA NA Rat Human +DTXSID2023145 Css NA 0.005616 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023145 Css NA 0.04136 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023145 Css NA 0.003123 mg/L PBTK NA 50% Rat Human +DTXSID2023145 Css NA 0.02274 mg/L PBTK NA 95% Rat Human DTXSID2023149 Clint NA 13.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2023149 Fup NA 0.0445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023149 Vd NA 0.2192 L/kg 1compartment NA NA Human Human +DTXSID2023149 Vd NA 0.2298 L/kg 1compartment NA NA Human Human DTXSID2023149 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023149 TK.Half.Life NA 1.577 hours 1compartment NA NA Human Human -DTXSID2023149 Css NA 1.18 mg/L 3compartmentss NA 50% Human Human -DTXSID2023149 Css NA 9.18 mg/L 3compartmentss NA 95% Human Human -DTXSID2023149 Css NA 0.7075 mg/L PBTK NA 50% Human Human -DTXSID2023149 Css NA 5.37 mg/L PBTK NA 95% Human Human +DTXSID2023149 TK.Half.Life NA 1.653 hours 1compartment NA NA Human Human +DTXSID2023149 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human +DTXSID2023149 Css NA 9.183 mg/L 3compartmentss NA 95% Human Human +DTXSID2023149 Css NA 0.6798 mg/L PBTK NA 50% Human Human +DTXSID2023149 Css NA 5.397 mg/L PBTK NA 95% Human Human DTXSID2023149 Clint NA 13.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2023149 Fup NA 0.0445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023149 Vd NA 0.216 L/kg 1compartment NA NA Rat Human +DTXSID2023149 Vd NA 0.2255 L/kg 1compartment NA NA Rat Human DTXSID2023149 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023149 TK.Half.Life NA 0.9922 hours 1compartment NA NA Rat Human -DTXSID2023149 Css NA 0.6616 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023149 Css NA 3.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023149 Css NA 0.3687 mg/L PBTK NA 50% Rat Human -DTXSID2023149 Css NA 2.172 mg/L PBTK NA 95% Rat Human +DTXSID2023149 TK.Half.Life NA 1.036 hours 1compartment NA NA Rat Human +DTXSID2023149 Css NA 0.1469 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023149 Css NA 0.9163 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023149 Css NA 0.08501 mg/L PBTK NA 50% Rat Human +DTXSID2023149 Css NA 0.5221 mg/L PBTK NA 95% Rat Human DTXSID2023191 Clint 5.841 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2023191 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023191 Vd NA 5.059 L/kg 1compartment NA NA Human Human +DTXSID2023191 Vd NA 5.054 L/kg 1compartment NA NA Human Human DTXSID2023191 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023191 TK.Half.Life NA 9.447 hours 1compartment NA NA Human Human -DTXSID2023191 Css NA 0.1047 mg/L 3compartmentss NA 50% Human Human -DTXSID2023191 Css NA 0.8216 mg/L 3compartmentss NA 95% Human Human -DTXSID2023191 Css NA 0.1414 mg/L PBTK NA 50% Human Human -DTXSID2023191 Css NA 0.8247 mg/L PBTK NA 95% Human Human +DTXSID2023191 TK.Half.Life NA 9.39 hours 1compartment NA NA Human Human +DTXSID2023191 Css NA 0.09899 mg/L 3compartmentss NA 50% Human Human +DTXSID2023191 Css NA 0.7556 mg/L 3compartmentss NA 95% Human Human +DTXSID2023191 Css NA 0.1332 mg/L PBTK NA 50% Human Human +DTXSID2023191 Css NA 0.7743 mg/L PBTK NA 95% Human Human DTXSID2023191 Clint 5.841 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2023191 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023191 Vd NA 4.918 L/kg 1compartment NA NA Rat Human +DTXSID2023191 Vd NA 4.915 L/kg 1compartment NA NA Rat Human DTXSID2023191 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023191 TK.Half.Life NA 4.099 hours 1compartment NA NA Rat Human -DTXSID2023191 Css NA 0.05092 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023191 Css NA 0.3217 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023191 Css NA 0.06923 mg/L PBTK NA 50% Rat Human -DTXSID2023191 Css NA 0.2938 mg/L PBTK NA 95% Rat Human +DTXSID2023191 TK.Half.Life NA 4.094 hours 1compartment NA NA Rat Human +DTXSID2023191 Css NA 0.009562 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023191 Css NA 0.06659 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023191 Css NA 0.01372 mg/L PBTK NA 50% Rat Human +DTXSID2023191 Css NA 0.06349 mg/L PBTK NA 95% Rat Human DTXSID2023193 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2023193 Fup NA 0.8874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023193 Vd NA 0.6335 L/kg 1compartment NA NA Human Human +DTXSID2023193 Vd NA 0.6739 L/kg 1compartment NA NA Human Human DTXSID2023193 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023193 TK.Half.Life NA 4.618 hours 1compartment NA NA Human Human -DTXSID2023193 Css NA 0.969 mg/L 3compartmentss NA 50% Human Human -DTXSID2023193 Css NA 5.284 mg/L 3compartmentss NA 95% Human Human -DTXSID2023193 Css NA 0.7766 mg/L PBTK NA 50% Human Human -DTXSID2023193 Css NA 3.388 mg/L PBTK NA 95% Human Human +DTXSID2023193 TK.Half.Life NA 4.912 hours 1compartment NA NA Human Human +DTXSID2023193 Css NA 0.8118 mg/L 3compartmentss NA 50% Human Human +DTXSID2023193 Css NA 4.458 mg/L 3compartmentss NA 95% Human Human +DTXSID2023193 Css NA 0.6586 mg/L PBTK NA 50% Human Human +DTXSID2023193 Css NA 2.902 mg/L PBTK NA 95% Human Human DTXSID2023193 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2023193 Fup NA 0.8874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023193 Vd NA 0.6842 L/kg 1compartment NA NA Rat Human +DTXSID2023193 Vd NA 0.717 L/kg 1compartment NA NA Rat Human DTXSID2023193 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023193 TK.Half.Life NA 1.7 hours 1compartment NA NA Rat Human -DTXSID2023193 Css NA 0.2467 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023193 Css NA 1.364 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023193 Css NA 0.1914 mg/L PBTK NA 50% Rat Human -DTXSID2023193 Css NA 0.8127 mg/L PBTK NA 95% Rat Human -DTXSID2023195 Clint NA 14.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023195 Fup NA 0.1184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023195 Vd NA 1.421 L/kg 1compartment NA NA Human Human +DTXSID2023193 TK.Half.Life NA 1.781 hours 1compartment NA NA Rat Human +DTXSID2023193 Css NA 0.01512 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023193 Css NA 0.1082 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023193 Css NA 0.01174 mg/L PBTK NA 50% Rat Human +DTXSID2023193 Css NA 0.07167 mg/L PBTK NA 95% Rat Human +DTXSID2023195 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023195 Fup 0.0891 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023195 Vd NA 1.24 L/kg 1compartment NA NA Human Human DTXSID2023195 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023195 TK.Half.Life NA 4.68 hours 1compartment NA NA Human Human -DTXSID2023195 Css NA 0.388 mg/L 3compartmentss NA 50% Human Human -DTXSID2023195 Css NA 2.847 mg/L 3compartmentss NA 95% Human Human -DTXSID2023195 Css NA 0.2606 mg/L PBTK NA 50% Human Human -DTXSID2023195 Css NA 1.779 mg/L PBTK NA 95% Human Human -DTXSID2023195 Clint NA 14.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023195 Fup NA 0.1184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023195 Vd NA 1.1 L/kg 1compartment NA NA Rat Human +DTXSID2023195 TK.Half.Life NA 9.532 hours 1compartment NA NA Human Human +DTXSID2023195 Css NA 1.075 mg/L 3compartmentss NA 50% Human Human +DTXSID2023195 Css NA 7.175 mg/L 3compartmentss NA 95% Human Human +DTXSID2023195 Css NA 0.6996 mg/L PBTK NA 50% Human Human +DTXSID2023195 Css NA 4.354 mg/L PBTK NA 95% Human Human +DTXSID2023195 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023195 Fup 0.0891 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023195 Vd NA 0.956 L/kg 1compartment NA NA Rat Human DTXSID2023195 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023195 TK.Half.Life NA 1.877 hours 1compartment NA NA Rat Human -DTXSID2023195 Css NA 0.2094 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023195 Css NA 1.164 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023195 Css NA 0.1329 mg/L PBTK NA 50% Rat Human -DTXSID2023195 Css NA 0.6927 mg/L PBTK NA 95% Rat Human -DTXSID2023197 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023197 Fup NA 0.1977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023197 Vd NA 0.383 L/kg 1compartment NA NA Human Human -DTXSID2023197 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2023197 TK.Half.Life NA 12.55 hours 1compartment NA NA Human Human -DTXSID2023197 Css NA 4.066 mg/L 3compartmentss NA 50% Human Human -DTXSID2023197 Css NA 14.63 mg/L 3compartmentss NA 95% Human Human -DTXSID2023197 Css NA 2.669 mg/L PBTK NA 50% Human Human -DTXSID2023197 Css NA 8.934 mg/L PBTK NA 95% Human Human -DTXSID2023197 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023197 Fup NA 0.1977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023197 Vd NA 0.3837 L/kg 1compartment NA NA Rat Human +DTXSID2023195 TK.Half.Life NA 3.941 hours 1compartment NA NA Rat Human +DTXSID2023195 Css NA 0.1319 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023195 Css NA 0.654 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023195 Css NA 0.08383 mg/L PBTK NA 50% Rat Human +DTXSID2023195 Css NA 0.3901 mg/L PBTK NA 95% Rat Human +DTXSID2023197 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023197 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023197 Vd NA 0.7837 L/kg 1compartment NA NA Human Human +DTXSID2023197 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023197 TK.Half.Life NA 8.704 hours 1compartment NA NA Human Human +DTXSID2023197 Css NA 1.07 mg/L 3compartmentss NA 50% Human Human +DTXSID2023197 Css NA 7.539 mg/L 3compartmentss NA 95% Human Human +DTXSID2023197 Css NA 0.86 mg/L PBTK NA 50% Human Human +DTXSID2023197 Css NA 4.726 mg/L PBTK NA 95% Human Human +DTXSID2023197 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023197 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023197 Vd NA 0.7896 L/kg 1compartment NA NA Rat Human DTXSID2023197 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023197 TK.Half.Life NA 4.281 hours 1compartment NA NA Rat Human -DTXSID2023197 Css NA 1.131 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023197 Css NA 3.351 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023197 Css NA 0.7016 mg/L PBTK NA 50% Rat Human -DTXSID2023197 Css NA 1.908 mg/L PBTK NA 95% Rat Human -DTXSID2023222 Clint NA 9.917 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023222 Fup NA 0.201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023222 Vd NA 0.842 L/kg 1compartment NA NA Human Human +DTXSID2023197 TK.Half.Life NA 2.98 hours 1compartment NA NA Rat Human +DTXSID2023197 Css NA 0.02016 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023197 Css NA 0.1754 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023197 Css NA 0.01575 mg/L PBTK NA 50% Rat Human +DTXSID2023197 Css NA 0.1109 mg/L PBTK NA 95% Rat Human +DTXSID2023222 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023222 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023222 Vd NA 0.8148 L/kg 1compartment NA NA Human Human DTXSID2023222 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023222 TK.Half.Life NA 2.204 hours 1compartment NA NA Human Human -DTXSID2023222 Css NA 0.2392 mg/L 3compartmentss NA 50% Human Human -DTXSID2023222 Css NA 1.447 mg/L 3compartmentss NA 95% Human Human -DTXSID2023222 Css NA 0.1668 mg/L PBTK NA 50% Human Human -DTXSID2023222 Css NA 0.9436 mg/L PBTK NA 95% Human Human -DTXSID2023222 Clint NA 9.917 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023222 Fup NA 0.201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023222 Vd NA 0.6969 L/kg 1compartment NA NA Rat Human +DTXSID2023222 TK.Half.Life NA 1.397 hours 1compartment NA NA Human Human +DTXSID2023222 Css NA 0.114 mg/L 3compartmentss NA 50% Human Human +DTXSID2023222 Css NA 0.8211 mg/L 3compartmentss NA 95% Human Human +DTXSID2023222 Css NA 0.0787 mg/L PBTK NA 50% Human Human +DTXSID2023222 Css NA 0.5307 mg/L PBTK NA 95% Human Human +DTXSID2023222 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023222 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023222 Vd NA 0.6742 L/kg 1compartment NA NA Rat Human DTXSID2023222 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023222 TK.Half.Life NA 1.023 hours 1compartment NA NA Rat Human -DTXSID2023222 Css NA 0.1265 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023222 Css NA 0.5795 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023222 Css NA 0.08442 mg/L PBTK NA 50% Rat Human -DTXSID2023222 Css NA 0.3551 mg/L PBTK NA 95% Rat Human +DTXSID2023222 TK.Half.Life NA 0.6261 hours 1compartment NA NA Rat Human +DTXSID2023222 Css NA 0.01461 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023222 Css NA 0.07727 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023222 Css NA 0.009977 mg/L PBTK NA 50% Rat Human +DTXSID2023222 Css NA 0.04928 mg/L PBTK NA 95% Rat Human DTXSID2023224 Clint 33.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2023224 Fup 0.00968 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2023224 Vd NA 2.958 L/kg 1compartment NA NA Human Human DTXSID2023224 Days.Css NA 5 Days PBTK NA NA Human Human DTXSID2023224 TK.Half.Life NA 45.81 hours 1compartment NA NA Human Human -DTXSID2023224 Css NA 1.805 mg/L 3compartmentss NA 50% Human Human -DTXSID2023224 Css NA 11.08 mg/L 3compartmentss NA 95% Human Human -DTXSID2023224 Css NA 1.248 mg/L PBTK NA 50% Human Human -DTXSID2023224 Css NA 7.323 mg/L PBTK NA 95% Human Human +DTXSID2023224 Css NA 1.739 mg/L 3compartmentss NA 50% Human Human +DTXSID2023224 Css NA 11.25 mg/L 3compartmentss NA 95% Human Human +DTXSID2023224 Css NA 1.204 mg/L PBTK NA 50% Human Human +DTXSID2023224 Css NA 7.439 mg/L PBTK NA 95% Human Human DTXSID2023224 Clint 33.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2023224 Fup 0.00968 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2023224 Vd NA 2.213 L/kg 1compartment NA NA Rat Human DTXSID2023224 Days.Css NA 3 Days PBTK NA NA Rat Human DTXSID2023224 TK.Half.Life NA 7.716 hours 1compartment NA NA Rat Human -DTXSID2023224 Css NA 1.012 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023224 Css NA 5.613 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023224 Css NA 0.6637 mg/L PBTK NA 50% Rat Human -DTXSID2023224 Css NA 3.644 mg/L PBTK NA 95% Rat Human +DTXSID2023224 Css NA 0.2276 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023224 Css NA 1.327 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023224 Css NA 0.1546 mg/L PBTK NA 50% Rat Human +DTXSID2023224 Css NA 0.9012 mg/L PBTK NA 95% Rat Human DTXSID2023226 Clint 34.66 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2023226 Fup 0.15 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID2023226 Vd NA 3.122 L/kg 1compartment NA NA Human Human DTXSID2023226 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID2023226 TK.Half.Life NA 34.61 hours 1compartment NA NA Human Human -DTXSID2023226 Css NA 1.532 mg/L 3compartmentss NA 50% Human Human -DTXSID2023226 Css NA 9.854 mg/L 3compartmentss NA 95% Human Human -DTXSID2023226 Css NA 0.8906 mg/L PBTK NA 50% Human Human -DTXSID2023226 Css NA 5.692 mg/L PBTK NA 95% Human Human +DTXSID2023226 Css NA 1.129 mg/L 3compartmentss NA 50% Human Human +DTXSID2023226 Css NA 7.05 mg/L 3compartmentss NA 95% Human Human +DTXSID2023226 Css NA 0.8693 mg/L PBTK NA 50% Human Human +DTXSID2023226 Css NA 5.428 mg/L PBTK NA 95% Human Human DTXSID2023226 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID2023226 Fup 0.26 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID2023226 Vd NA 2.35 L/kg 1compartment NA NA Rat Rat -DTXSID2023226 Days.Css NA 651 Days PBTK NA NA Rat Rat +DTXSID2023226 Days.Css NA 727 Days PBTK NA NA Rat Rat DTXSID2023226 TK.Half.Life NA 641.8 hours 1compartment NA NA Rat Rat -DTXSID2023226 Css NA 123.8 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2023226 Css NA 246.4 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2023226 Css NA 67.07 mg/L PBTK NA 50% Rat Rat -DTXSID2023226 Css NA 133.3 mg/L PBTK NA 95% Rat Rat +DTXSID2023226 Css NA 19.7 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2023226 Css NA 39.3 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2023226 Css NA 15.7 mg/L PBTK NA 50% Rat Rat +DTXSID2023226 Css NA 31.34 mg/L PBTK NA 95% Rat Rat DTXSID2023270 Clint NA 0.02376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2023270 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023270 Vd NA 1.67 L/kg 1compartment NA NA Human Human -DTXSID2023270 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2023270 TK.Half.Life NA 10.39 hours 1compartment NA NA Human Human -DTXSID2023270 Css NA 0.3702 mg/L 3compartmentss NA 50% Human Human -DTXSID2023270 Css NA 2.652 mg/L 3compartmentss NA 95% Human Human -DTXSID2023270 Css NA 0.346 mg/L PBTK NA 50% Human Human -DTXSID2023270 Css NA 1.82 mg/L PBTK NA 95% Human Human +DTXSID2023270 Vd NA 1.242 L/kg 1compartment NA NA Human Human +DTXSID2023270 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023270 TK.Half.Life NA 7.735 hours 1compartment NA NA Human Human +DTXSID2023270 Css NA 0.5432 mg/L 3compartmentss NA 50% Human Human +DTXSID2023270 Css NA 2.741 mg/L 3compartmentss NA 95% Human Human +DTXSID2023270 Css NA 0.5647 mg/L PBTK NA 50% Human Human +DTXSID2023270 Css NA 2.85 mg/L PBTK NA 95% Human Human DTXSID2023270 Clint NA 0.02376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2023270 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023270 Vd NA 1.654 L/kg 1compartment NA NA Rat Human +DTXSID2023270 Vd NA 1.241 L/kg 1compartment NA NA Rat Human DTXSID2023270 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023270 TK.Half.Life NA 3.578 hours 1compartment NA NA Rat Human -DTXSID2023270 Css NA 0.1836 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023270 Css NA 1.251 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023270 Css NA 0.1697 mg/L PBTK NA 50% Rat Human -DTXSID2023270 Css NA 0.7792 mg/L PBTK NA 95% Rat Human -DTXSID2023276 Clint NA 8.048 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023276 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023276 Vd NA 1.948 L/kg 1compartment NA NA Human Human -DTXSID2023276 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2023276 TK.Half.Life NA 17.74 hours 1compartment NA NA Human Human -DTXSID2023276 Css NA 1.275 mg/L 3compartmentss NA 50% Human Human -DTXSID2023276 Css NA 7.924 mg/L 3compartmentss NA 95% Human Human -DTXSID2023276 Css NA 0.8488 mg/L PBTK NA 50% Human Human -DTXSID2023276 Css NA 5.019 mg/L PBTK NA 95% Human Human -DTXSID2023276 Clint NA 8.048 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023276 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023276 Vd NA 1.468 L/kg 1compartment NA NA Rat Human +DTXSID2023270 TK.Half.Life NA 2.685 hours 1compartment NA NA Rat Human +DTXSID2023270 Css NA 0.009824 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023270 Css NA 0.06446 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023270 Css NA 0.01031 mg/L PBTK NA 50% Rat Human +DTXSID2023270 Css NA 0.06834 mg/L PBTK NA 95% Rat Human +DTXSID2023276 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023276 Fup 0.0744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023276 Vd NA 1.891 L/kg 1compartment NA NA Human Human +DTXSID2023276 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023276 TK.Half.Life NA 7.418 hours 1compartment NA NA Human Human +DTXSID2023276 Css NA 0.4664 mg/L 3compartmentss NA 50% Human Human +DTXSID2023276 Css NA 3.298 mg/L 3compartmentss NA 95% Human Human +DTXSID2023276 Css NA 0.3101 mg/L PBTK NA 50% Human Human +DTXSID2023276 Css NA 2.088 mg/L PBTK NA 95% Human Human +DTXSID2023276 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023276 Fup 0.0744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023276 Vd NA 1.426 L/kg 1compartment NA NA Rat Human DTXSID2023276 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023276 TK.Half.Life NA 5.796 hours 1compartment NA NA Rat Human -DTXSID2023276 Css NA 0.6909 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023276 Css NA 3.191 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023276 Css NA 0.4351 mg/L PBTK NA 50% Rat Human -DTXSID2023276 Css NA 1.889 mg/L PBTK NA 95% Rat Human -DTXSID2023303 Clint NA 3.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023303 Fup NA 0.1448 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023303 Vd NA 0.762 L/kg 1compartment NA NA Human Human -DTXSID2023303 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023303 TK.Half.Life NA 5.527 hours 1compartment NA NA Human Human -DTXSID2023303 Css NA 0.9814 mg/L 3compartmentss NA 50% Human Human -DTXSID2023303 Css NA 6.053 mg/L 3compartmentss NA 95% Human Human -DTXSID2023303 Css NA 0.6421 mg/L PBTK NA 50% Human Human -DTXSID2023303 Css NA 3.742 mg/L PBTK NA 95% Human Human -DTXSID2023303 Clint NA 3.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023303 Fup NA 0.1448 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023303 Vd NA 0.6209 L/kg 1compartment NA NA Rat Human +DTXSID2023276 TK.Half.Life NA 2.542 hours 1compartment NA NA Rat Human +DTXSID2023276 Css NA 0.06018 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023276 Css NA 0.3416 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023276 Css NA 0.039 mg/L PBTK NA 50% Rat Human +DTXSID2023276 Css NA 0.2129 mg/L PBTK NA 95% Rat Human +DTXSID2023278 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023278 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023278 Vd NA 3.101 L/kg 1compartment NA NA Human Human +DTXSID2023278 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023278 TK.Half.Life NA 4.058 hours 1compartment NA NA Human Human +DTXSID2023278 Css NA 0.06765 mg/L 3compartmentss NA 50% Human Human +DTXSID2023278 Css NA 0.5059 mg/L 3compartmentss NA 95% Human Human +DTXSID2023278 Css NA 0.06526 mg/L PBTK NA 50% Human Human +DTXSID2023278 Css NA 0.4195 mg/L PBTK NA 95% Human Human +DTXSID2023278 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023278 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023278 Vd NA 2.923 L/kg 1compartment NA NA Rat Human +DTXSID2023278 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2023278 TK.Half.Life NA 1.918 hours 1compartment NA NA Rat Human +DTXSID2023278 Css NA 0.008282 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023278 Css NA 0.04884 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023278 Css NA 0.008234 mg/L PBTK NA 50% Rat Human +DTXSID2023278 Css NA 0.0422 mg/L PBTK NA 95% Rat Human +DTXSID2023303 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023303 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023303 Vd NA 1.062 L/kg 1compartment NA NA Human Human +DTXSID2023303 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2023303 TK.Half.Life NA 30.97 hours 1compartment NA NA Human Human +DTXSID2023303 Css NA 2.835 mg/L 3compartmentss NA 50% Human Human +DTXSID2023303 Css NA 10.56 mg/L 3compartmentss NA 95% Human Human +DTXSID2023303 Css NA 2.046 mg/L PBTK NA 50% Human Human +DTXSID2023303 Css NA 6.772 mg/L PBTK NA 95% Human Human +DTXSID2023303 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023303 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023303 Vd NA 0.864 L/kg 1compartment NA NA Rat Human DTXSID2023303 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023303 TK.Half.Life NA 2.519 hours 1compartment NA NA Rat Human -DTXSID2023303 Css NA 0.4938 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023303 Css NA 2.319 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023303 Css NA 0.3032 mg/L PBTK NA 50% Rat Human -DTXSID2023303 Css NA 1.316 mg/L PBTK NA 95% Rat Human -DTXSID2023307 Clint NA 17.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023307 Fup NA 0.1285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023307 Vd NA 0.9621 L/kg 1compartment NA NA Human Human -DTXSID2023307 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023307 TK.Half.Life NA 2.368 hours 1compartment NA NA Human Human -DTXSID2023307 Css NA 0.2621 mg/L 3compartmentss NA 50% Human Human -DTXSID2023307 Css NA 2.047 mg/L 3compartmentss NA 95% Human Human -DTXSID2023307 Css NA 0.1733 mg/L PBTK NA 50% Human Human -DTXSID2023307 Css NA 1.291 mg/L PBTK NA 95% Human Human -DTXSID2023307 Clint NA 17.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023307 Fup NA 0.1285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023307 Vd NA 0.7996 L/kg 1compartment NA NA Rat Human +DTXSID2023303 TK.Half.Life NA 7.782 hours 1compartment NA NA Rat Human +DTXSID2023303 Css NA 0.06844 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023303 Css NA 0.3608 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023303 Css NA 0.04838 mg/L PBTK NA 50% Rat Human +DTXSID2023303 Css NA 0.2298 mg/L PBTK NA 95% Rat Human +DTXSID2023307 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023307 Fup 0.564 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023307 Vd NA 1.796 L/kg 1compartment NA NA Human Human +DTXSID2023307 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2023307 TK.Half.Life NA 29.65 hours 1compartment NA NA Human Human +DTXSID2023307 Css NA 1.676 mg/L 3compartmentss NA 50% Human Human +DTXSID2023307 Css NA 9.509 mg/L 3compartmentss NA 95% Human Human +DTXSID2023307 Css NA 1.404 mg/L PBTK NA 50% Human Human +DTXSID2023307 Css NA 6.198 mg/L PBTK NA 95% Human Human +DTXSID2023307 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023307 Fup 0.564 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023307 Vd NA 1.455 L/kg 1compartment NA NA Rat Human DTXSID2023307 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023307 TK.Half.Life NA 1.107 hours 1compartment NA NA Rat Human -DTXSID2023307 Css NA 0.1427 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023307 Css NA 0.8615 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023307 Css NA 0.08929 mg/L PBTK NA 50% Rat Human -DTXSID2023307 Css NA 0.5 mg/L PBTK NA 95% Rat Human +DTXSID2023307 TK.Half.Life NA 6.284 hours 1compartment NA NA Rat Human +DTXSID2023307 Css NA 0.1038 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023307 Css NA 0.5404 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023307 Css NA 0.08659 mg/L PBTK NA 50% Rat Human +DTXSID2023307 Css NA 0.3403 mg/L PBTK NA 95% Rat Human DTXSID2023309 Clint 6.231 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2023309 Fup 0.883 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Human Human DTXSID2023309 Vd NA 3.584 L/kg 1compartment NA NA Human Human DTXSID2023309 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2023309 TK.Half.Life NA 3.667 hours 1compartment NA NA Human Human -DTXSID2023309 Css NA 0.07226 mg/L 3compartmentss NA 50% Human Human -DTXSID2023309 Css NA 0.6282 mg/L 3compartmentss NA 95% Human Human -DTXSID2023309 Css NA 0.06879 mg/L PBTK NA 50% Human Human -DTXSID2023309 Css NA 0.4688 mg/L PBTK NA 95% Human Human +DTXSID2023309 Css NA 0.06122 mg/L 3compartmentss NA 50% Human Human +DTXSID2023309 Css NA 0.4523 mg/L 3compartmentss NA 95% Human Human +DTXSID2023309 Css NA 0.06507 mg/L PBTK NA 50% Human Human +DTXSID2023309 Css NA 0.4824 mg/L PBTK NA 95% Human Human DTXSID2023309 Clint 21.04 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID2023309 Fup 0.7 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID2023309 Vd NA 3.013 L/kg 1compartment NA NA Rat Rat DTXSID2023309 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID2023309 TK.Half.Life NA 1.004 hours 1compartment NA NA Rat Rat -DTXSID2023309 Css NA 0.0128 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2023309 Css NA 0.1262 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2023309 Css NA 0.01261 mg/L PBTK NA 50% Rat Rat -DTXSID2023309 Css NA 0.09121 mg/L PBTK NA 95% Rat Rat -DTXSID2023353 Clint NA 96.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023353 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023353 Vd NA 15.31 L/kg 1compartment NA NA Human Human -DTXSID2023353 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID2023353 TK.Half.Life NA 106.1 hours 1compartment NA NA Human Human -DTXSID2023353 Css NA 0.3246 mg/L 3compartmentss NA 50% Human Human -DTXSID2023353 Css NA 1.952 mg/L 3compartmentss NA 95% Human Human -DTXSID2023353 Css NA 0.5472 mg/L PBTK NA 50% Human Human -DTXSID2023353 Css NA 3.127 mg/L PBTK NA 95% Human Human -DTXSID2023353 Clint NA 96.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023353 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023353 Vd NA 12.28 L/kg 1compartment NA NA Rat Human -DTXSID2023353 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID2023353 TK.Half.Life NA 15.73 hours 1compartment NA NA Rat Human -DTXSID2023353 Css NA 0.1763 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023353 Css NA 0.7259 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023353 Css NA 0.2984 mg/L PBTK NA 50% Rat Human -DTXSID2023353 Css NA 1.222 mg/L PBTK NA 95% Rat Human +DTXSID2023309 Css NA 0.00251 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2023309 Css NA 0.01975 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2023309 Css NA 0.002788 mg/L PBTK NA 50% Rat Rat +DTXSID2023309 Css NA 0.02189 mg/L PBTK NA 95% Rat Rat +DTXSID2023353 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023353 Fup 0.0657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023353 Vd NA 1.129 L/kg 1compartment NA NA Human Human +DTXSID2023353 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023353 TK.Half.Life NA 4.068 hours 1compartment NA NA Human Human +DTXSID2023353 Css NA 0.421 mg/L 3compartmentss NA 50% Human Human +DTXSID2023353 Css NA 3.073 mg/L 3compartmentss NA 95% Human Human +DTXSID2023353 Css NA 0.27 mg/L PBTK NA 50% Human Human +DTXSID2023353 Css NA 1.902 mg/L PBTK NA 95% Human Human +DTXSID2023353 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023353 Fup 0.0657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023353 Vd NA 0.8643 L/kg 1compartment NA NA Rat Human +DTXSID2023353 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2023353 TK.Half.Life NA 1.727 hours 1compartment NA NA Rat Human +DTXSID2023353 Css NA 0.05534 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023353 Css NA 0.3049 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023353 Css NA 0.0345 mg/L PBTK NA 50% Rat Human +DTXSID2023353 Css NA 0.1828 mg/L PBTK NA 95% Rat Human +DTXSID2023357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023357 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2023357 Vd NA 1.488 L/kg 1compartment NA NA Human Human +DTXSID2023357 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2023357 TK.Half.Life NA 22.24 hours 1compartment NA NA Human Human +DTXSID2023357 Css NA 2.404 mg/L 3compartmentss NA 50% Human Human +DTXSID2023357 Css NA 22.2 mg/L 3compartmentss NA 95% Human Human +DTXSID2023357 Css NA 1.504 mg/L PBTK NA 50% Human Human +DTXSID2023357 Css NA 13.36 mg/L PBTK NA 95% Human Human +DTXSID2023357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023357 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2023357 Vd NA 1.121 L/kg 1compartment NA NA Rat Human +DTXSID2023357 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2023357 TK.Half.Life NA 8.961 hours 1compartment NA NA Rat Human +DTXSID2023357 Css NA 0.3142 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023357 Css NA 2.446 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023357 Css NA 0.1906 mg/L PBTK NA 50% Rat Human +DTXSID2023357 Css NA 1.441 mg/L PBTK NA 95% Rat Human DTXSID2023430 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2023430 Fup NA 0.1143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023430 Vd NA 0.422 L/kg 1compartment NA NA Human Human -DTXSID2023430 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2023430 TK.Half.Life NA 24.19 hours 1compartment NA NA Human Human -DTXSID2023430 Css NA 8.754 mg/L 3compartmentss NA 50% Human Human -DTXSID2023430 Css NA 40.92 mg/L 3compartmentss NA 95% Human Human -DTXSID2023430 Css NA 5.472 mg/L PBTK NA 50% Human Human -DTXSID2023430 Css NA 24.26 mg/L PBTK NA 95% Human Human +DTXSID2023430 Vd NA 0.5147 L/kg 1compartment NA NA Human Human +DTXSID2023430 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2023430 TK.Half.Life NA 29.88 hours 1compartment NA NA Human Human +DTXSID2023430 Css NA 7.471 mg/L 3compartmentss NA 50% Human Human +DTXSID2023430 Css NA 34.73 mg/L 3compartmentss NA 95% Human Human +DTXSID2023430 Css NA 4.725 mg/L PBTK NA 50% Human Human +DTXSID2023430 Css NA 20.87 mg/L PBTK NA 95% Human Human DTXSID2023430 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2023430 Fup NA 0.1143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023430 Vd NA 0.3765 L/kg 1compartment NA NA Rat Human +DTXSID2023430 Vd NA 0.4405 L/kg 1compartment NA NA Rat Human DTXSID2023430 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023430 TK.Half.Life NA 7.288 hours 1compartment NA NA Rat Human -DTXSID2023430 Css NA 2.47 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023430 Css NA 9.521 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023430 Css NA 1.445 mg/L PBTK NA 50% Rat Human -DTXSID2023430 Css NA 5.259 mg/L PBTK NA 95% Rat Human +DTXSID2023430 TK.Half.Life NA 8.55 hours 1compartment NA NA Rat Human +DTXSID2023430 Css NA 0.1801 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023430 Css NA 1.181 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023430 Css NA 0.1103 mg/L PBTK NA 50% Rat Human +DTXSID2023430 Css NA 0.6782 mg/L PBTK NA 95% Rat Human DTXSID2023434 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2023434 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023434 Vd NA 1.73 L/kg 1compartment NA NA Human Human -DTXSID2023434 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2023434 TK.Half.Life NA 11.2 hours 1compartment NA NA Human Human -DTXSID2023434 Css NA 0.6992 mg/L 3compartmentss NA 50% Human Human -DTXSID2023434 Css NA 5.261 mg/L 3compartmentss NA 95% Human Human -DTXSID2023434 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID2023434 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID2023434 Vd NA 0.702 L/kg 1compartment NA NA Human Human +DTXSID2023434 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023434 TK.Half.Life NA 4.542 hours 1compartment NA NA Human Human +DTXSID2023434 Css NA 0.7119 mg/L 3compartmentss NA 50% Human Human +DTXSID2023434 Css NA 5.067 mg/L 3compartmentss NA 95% Human Human +DTXSID2023434 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID2023434 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID2023434 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2023434 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023434 Vd NA 1.778 L/kg 1compartment NA NA Rat Human +DTXSID2023434 Vd NA 0.752 L/kg 1compartment NA NA Rat Human DTXSID2023434 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023434 TK.Half.Life NA 3.921 hours 1compartment NA NA Rat Human -DTXSID2023434 Css NA 0.1719 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023434 Css NA 1.252 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023434 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID2023434 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID2023436 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2023434 TK.Half.Life NA 1.658 hours 1compartment NA NA Rat Human +DTXSID2023434 Css NA 0.01306 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023434 Css NA 0.1001 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023434 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID2023434 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID2023436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2023436 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023436 Vd NA 1.72 L/kg 1compartment NA NA Human Human -DTXSID2023436 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2023436 TK.Half.Life NA 11.59 hours 1compartment NA NA Human Human -DTXSID2023436 Css NA 0.7487 mg/L 3compartmentss NA 50% Human Human -DTXSID2023436 Css NA 4.762 mg/L 3compartmentss NA 95% Human Human -DTXSID2023436 Css NA 0.7464 mg/L PBTK NA 50% Human Human -DTXSID2023436 Css NA 3.334 mg/L PBTK NA 95% Human Human -DTXSID2023436 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2023436 Vd NA 0.739 L/kg 1compartment NA NA Human Human +DTXSID2023436 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023436 TK.Half.Life NA 4.983 hours 1compartment NA NA Human Human +DTXSID2023436 Css NA 0.7802 mg/L 3compartmentss NA 50% Human Human +DTXSID2023436 Css NA 4.38 mg/L 3compartmentss NA 95% Human Human +DTXSID2023436 Css NA 0.6408 mg/L PBTK NA 50% Human Human +DTXSID2023436 Css NA 2.886 mg/L PBTK NA 95% Human Human +DTXSID2023436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2023436 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023436 Vd NA 1.761 L/kg 1compartment NA NA Rat Human +DTXSID2023436 Vd NA 0.7789 L/kg 1compartment NA NA Rat Human DTXSID2023436 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023436 TK.Half.Life NA 4.044 hours 1compartment NA NA Rat Human -DTXSID2023436 Css NA 0.1876 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023436 Css NA 1.178 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023436 Css NA 0.1837 mg/L PBTK NA 50% Rat Human -DTXSID2023436 Css NA 0.7608 mg/L PBTK NA 95% Rat Human -DTXSID2023480 Clint NA 1.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023480 Fup NA 0.9814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023480 Vd NA 5.597 L/kg 1compartment NA NA Human Human -DTXSID2023480 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID2023480 TK.Half.Life NA 40.82 hours 1compartment NA NA Human Human -DTXSID2023480 Css NA 0.4676 mg/L 3compartmentss NA 50% Human Human -DTXSID2023480 Css NA 4.504 mg/L 3compartmentss NA 95% Human Human -DTXSID2023480 Css NA 0.6179 mg/L PBTK NA 50% Human Human -DTXSID2023480 Css NA 4.057 mg/L PBTK NA 95% Human Human -DTXSID2023480 Clint NA 1.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023480 Fup NA 0.9814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023480 Vd NA 5.197 L/kg 1compartment NA NA Rat Human -DTXSID2023480 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2023480 TK.Half.Life NA 8.558 hours 1compartment NA NA Rat Human -DTXSID2023480 Css NA 0.1926 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023480 Css NA 1.384 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023480 Css NA 0.2594 mg/L PBTK NA 50% Rat Human -DTXSID2023480 Css NA 1.13 mg/L PBTK NA 95% Rat Human -DTXSID2023488 Clint NA 4.929 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2023436 TK.Half.Life NA 1.789 hours 1compartment NA NA Rat Human +DTXSID2023436 Css NA 0.01999 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023436 Css NA 0.1243 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023436 Css NA 0.01595 mg/L PBTK NA 50% Rat Human +DTXSID2023436 Css NA 0.08075 mg/L PBTK NA 95% Rat Human +DTXSID2023480 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023480 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023480 Vd NA 1.124 L/kg 1compartment NA NA Human Human +DTXSID2023480 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023480 TK.Half.Life NA 2.2 hours 1compartment NA NA Human Human +DTXSID2023480 Css NA 0.1702 mg/L 3compartmentss NA 50% Human Human +DTXSID2023480 Css NA 1.419 mg/L 3compartmentss NA 95% Human Human +DTXSID2023480 Css NA 0.1204 mg/L PBTK NA 50% Human Human +DTXSID2023480 Css NA 0.9108 mg/L PBTK NA 95% Human Human +DTXSID2023480 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023480 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023480 Vd NA 1.115 L/kg 1compartment NA NA Rat Human +DTXSID2023480 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2023480 TK.Half.Life NA 1.27 hours 1compartment NA NA Rat Human +DTXSID2023480 Css NA 0.02162 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023480 Css NA 0.1458 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023480 Css NA 0.01502 mg/L PBTK NA 50% Rat Human +DTXSID2023480 Css NA 0.0907 mg/L PBTK NA 95% Rat Human +DTXSID2023482 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023482 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2023482 Vd NA 0.4851 L/kg 1compartment NA NA Human Human +DTXSID2023482 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023482 TK.Half.Life NA 0.8286 hours 1compartment NA NA Human Human +DTXSID2023482 Css NA 0.03308 mg/L 3compartmentss NA 50% Human Human +DTXSID2023482 Css NA 0.3138 mg/L 3compartmentss NA 95% Human Human +DTXSID2023482 Css NA 0.02456 mg/L PBTK NA 50% Human Human +DTXSID2023482 Css NA 0.2071 mg/L PBTK NA 95% Human Human +DTXSID2023482 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023482 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2023482 Vd NA 0.4955 L/kg 1compartment NA NA Rat Human +DTXSID2023482 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2023482 TK.Half.Life NA 0.4621 hours 1compartment NA NA Rat Human +DTXSID2023482 Css NA 0.000237 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023482 Css NA 0.001802 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023482 Css NA 0.0001694 mg/L PBTK NA 50% Rat Human +DTXSID2023482 Css NA 0.001101 mg/L PBTK NA 95% Rat Human +DTXSID2023488 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2023488 Fup 0.058 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2023488 Vd NA 0.9924 L/kg 1compartment NA NA Human Human DTXSID2023488 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2023488 TK.Half.Life NA 13.02 hours 1compartment NA NA Human Human -DTXSID2023488 Css NA 2.062 mg/L 3compartmentss NA 50% Human Human -DTXSID2023488 Css NA 14.12 mg/L 3compartmentss NA 95% Human Human -DTXSID2023488 Css NA 1.314 mg/L PBTK NA 50% Human Human -DTXSID2023488 Css NA 8.524 mg/L PBTK NA 95% Human Human -DTXSID2023488 Clint NA 4.929 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2023488 TK.Half.Life NA 10.65 hours 1compartment NA NA Human Human +DTXSID2023488 Css NA 1.431 mg/L 3compartmentss NA 50% Human Human +DTXSID2023488 Css NA 10.45 mg/L 3compartmentss NA 95% Human Human +DTXSID2023488 Css NA 0.9102 mg/L PBTK NA 50% Human Human +DTXSID2023488 Css NA 6.261 mg/L PBTK NA 95% Human Human +DTXSID2023488 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2023488 Fup 0.058 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2023488 Vd NA 0.7623 L/kg 1compartment NA NA Rat Human DTXSID2023488 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023488 TK.Half.Life NA 5.59 hours 1compartment NA NA Rat Human -DTXSID2023488 Css NA 1.092 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023488 Css NA 5.086 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023488 Css NA 0.6544 mg/L PBTK NA 50% Rat Human -DTXSID2023488 Css NA 2.886 mg/L PBTK NA 95% Rat Human +DTXSID2023488 TK.Half.Life NA 4.63 hours 1compartment NA NA Rat Human +DTXSID2023488 Css NA 0.06686 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023488 Css NA 0.4912 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023488 Css NA 0.0414 mg/L PBTK NA 50% Rat Human +DTXSID2023488 Css NA 0.288 mg/L PBTK NA 95% Rat Human +DTXSID2023515 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID2023515 Fup 0.222 NA NA Williamson 2020 NA Human Human +DTXSID2023515 Vd NA 4.553 L/kg 1compartment NA NA Human Human +DTXSID2023515 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2023515 TK.Half.Life NA 19.29 hours 1compartment NA NA Human Human +DTXSID2023515 Css NA 0.2966 mg/L 3compartmentss NA 50% Human Human +DTXSID2023515 Css NA 1.725 mg/L 3compartmentss NA 95% Human Human +DTXSID2023515 Css NA 0.33 mg/L PBTK NA 50% Human Human +DTXSID2023515 Css NA 1.709 mg/L PBTK NA 95% Human Human +DTXSID2023515 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID2023515 Fup 0.222 NA NA Williamson 2020 NA Rat Human +DTXSID2023515 Vd NA 4.22 L/kg 1compartment NA NA Rat Human +DTXSID2023515 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2023515 TK.Half.Life NA 6.717 hours 1compartment NA NA Rat Human +DTXSID2023515 Css NA 0.03398 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023515 Css NA 0.1563 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023515 Css NA 0.03919 mg/L PBTK NA 50% Rat Human +DTXSID2023515 Css NA 0.1551 mg/L PBTK NA 95% Rat Human DTXSID2023517 Clint 22.59 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2023517 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023517 Vd NA 3.196 L/kg 1compartment NA NA Human Human -DTXSID2023517 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID2023517 TK.Half.Life NA 55.06 hours 1compartment NA NA Human Human -DTXSID2023517 Css NA 1.921 mg/L 3compartmentss NA 50% Human Human -DTXSID2023517 Css NA 12.54 mg/L 3compartmentss NA 95% Human Human -DTXSID2023517 Css NA 1.424 mg/L PBTK NA 50% Human Human -DTXSID2023517 Css NA 8.921 mg/L PBTK NA 95% Human Human +DTXSID2023517 Vd NA 4.348 L/kg 1compartment NA NA Human Human +DTXSID2023517 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2023517 TK.Half.Life NA 36.37 hours 1compartment NA NA Human Human +DTXSID2023517 Css NA 0.6454 mg/L 3compartmentss NA 50% Human Human +DTXSID2023517 Css NA 4.404 mg/L 3compartmentss NA 95% Human Human +DTXSID2023517 Css NA 0.6836 mg/L PBTK NA 50% Human Human +DTXSID2023517 Css NA 4.216 mg/L PBTK NA 95% Human Human DTXSID2023517 Clint 22.59 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2023517 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023517 Vd NA 2.4 L/kg 1compartment NA NA Rat Human -DTXSID2023517 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2023517 TK.Half.Life NA 8.322 hours 1compartment NA NA Rat Human -DTXSID2023517 Css NA 1.105 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023517 Css NA 5.959 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023517 Css NA 0.7871 mg/L PBTK NA 50% Rat Human -DTXSID2023517 Css NA 4.182 mg/L PBTK NA 95% Rat Human -DTXSID2023519 Clint NA 3.814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023519 Fup NA 0.9105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023519 Vd NA 3.271 L/kg 1compartment NA NA Human Human -DTXSID2023519 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID2023519 TK.Half.Life NA 123.8 hours 1compartment NA NA Human Human -DTXSID2023519 Css NA 4.438 mg/L 3compartmentss NA 50% Human Human -DTXSID2023519 Css NA 25.72 mg/L 3compartmentss NA 95% Human Human -DTXSID2023519 Css NA 3.225 mg/L PBTK NA 50% Human Human -DTXSID2023519 Css NA 17.72 mg/L PBTK NA 95% Human Human -DTXSID2023519 Clint NA 3.814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023519 Fup NA 0.9105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023519 Vd NA 2.502 L/kg 1compartment NA NA Rat Human -DTXSID2023519 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID2023519 TK.Half.Life NA 16.1 hours 1compartment NA NA Rat Human -DTXSID2023519 Css NA 2.378 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023519 Css NA 10.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023519 Css NA 1.661 mg/L PBTK NA 50% Rat Human -DTXSID2023519 Css NA 7.202 mg/L PBTK NA 95% Rat Human -DTXSID2023565 Clint NA 6.216 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2023517 Vd NA 3.509 L/kg 1compartment NA NA Rat Human +DTXSID2023517 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID2023517 TK.Half.Life NA 8.427 hours 1compartment NA NA Rat Human +DTXSID2023517 Css NA 0.09818 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023517 Css NA 0.563 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023517 Css NA 0.0999 mg/L PBTK NA 50% Rat Human +DTXSID2023517 Css NA 0.5259 mg/L PBTK NA 95% Rat Human +DTXSID2023519 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023519 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023519 Vd NA 0.6802 L/kg 1compartment NA NA Human Human +DTXSID2023519 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023519 TK.Half.Life NA 1.338 hours 1compartment NA NA Human Human +DTXSID2023519 Css NA 0.169 mg/L 3compartmentss NA 50% Human Human +DTXSID2023519 Css NA 1.411 mg/L 3compartmentss NA 95% Human Human +DTXSID2023519 Css NA 0.1128 mg/L PBTK NA 50% Human Human +DTXSID2023519 Css NA 0.8786 mg/L PBTK NA 95% Human Human +DTXSID2023519 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023519 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023519 Vd NA 0.6743 L/kg 1compartment NA NA Rat Human +DTXSID2023519 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2023519 TK.Half.Life NA 0.7619 hours 1compartment NA NA Rat Human +DTXSID2023519 Css NA 0.02196 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023519 Css NA 0.1448 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023519 Css NA 0.01426 mg/L PBTK NA 50% Rat Human +DTXSID2023519 Css NA 0.08854 mg/L PBTK NA 95% Rat Human +DTXSID2023565 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2023565 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023565 Vd NA 1.928 L/kg 1compartment NA NA Human Human +DTXSID2023565 Vd NA 2.015 L/kg 1compartment NA NA Human Human DTXSID2023565 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023565 TK.Half.Life NA 2.359 hours 1compartment NA NA Human Human -DTXSID2023565 Css NA 0.07336 mg/L 3compartmentss NA 50% Human Human -DTXSID2023565 Css NA 0.6023 mg/L 3compartmentss NA 95% Human Human -DTXSID2023565 Css NA 0.06546 mg/L PBTK NA 50% Human Human -DTXSID2023565 Css NA 0.4359 mg/L PBTK NA 95% Human Human -DTXSID2023565 Clint NA 6.216 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2023565 TK.Half.Life NA 2.518 hours 1compartment NA NA Human Human +DTXSID2023565 Css NA 0.07433 mg/L 3compartmentss NA 50% Human Human +DTXSID2023565 Css NA 0.5314 mg/L 3compartmentss NA 95% Human Human +DTXSID2023565 Css NA 0.0768 mg/L PBTK NA 50% Human Human +DTXSID2023565 Css NA 0.5518 mg/L PBTK NA 95% Human Human +DTXSID2023565 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2023565 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023565 Vd NA 1.712 L/kg 1compartment NA NA Rat Human +DTXSID2023565 Vd NA 1.772 L/kg 1compartment NA NA Rat Human DTXSID2023565 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023565 TK.Half.Life NA 1.012 hours 1compartment NA NA Rat Human -DTXSID2023565 Css NA 0.04213 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023565 Css NA 0.2988 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023565 Css NA 0.03742 mg/L PBTK NA 50% Rat Human -DTXSID2023565 Css NA 0.1995 mg/L PBTK NA 95% Rat Human -DTXSID2023567 Clint NA 6.629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2023565 TK.Half.Life NA 1.051 hours 1compartment NA NA Rat Human +DTXSID2023565 Css NA 0.008188 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023565 Css NA 0.04233 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023565 Css NA 0.008824 mg/L PBTK NA 50% Rat Human +DTXSID2023565 Css NA 0.0456 mg/L PBTK NA 95% Rat Human +DTXSID2023567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2023567 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023567 Vd NA 2.306 L/kg 1compartment NA NA Human Human -DTXSID2023567 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2023567 TK.Half.Life NA 19.16 hours 1compartment NA NA Human Human -DTXSID2023567 Css NA 1.052 mg/L 3compartmentss NA 50% Human Human -DTXSID2023567 Css NA 6.219 mg/L 3compartmentss NA 95% Human Human -DTXSID2023567 Css NA 0.728 mg/L PBTK NA 50% Human Human -DTXSID2023567 Css NA 4.107 mg/L PBTK NA 95% Human Human -DTXSID2023567 Clint NA 6.629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2023567 Vd NA 1.699 L/kg 1compartment NA NA Human Human +DTXSID2023567 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023567 TK.Half.Life NA 4.232 hours 1compartment NA NA Human Human +DTXSID2023567 Css NA 0.2416 mg/L 3compartmentss NA 50% Human Human +DTXSID2023567 Css NA 1.803 mg/L 3compartmentss NA 95% Human Human +DTXSID2023567 Css NA 0.164 mg/L PBTK NA 50% Human Human +DTXSID2023567 Css NA 1.167 mg/L PBTK NA 95% Human Human +DTXSID2023567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2023567 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023567 Vd NA 1.748 L/kg 1compartment NA NA Rat Human +DTXSID2023567 Vd NA 1.304 L/kg 1compartment NA NA Rat Human DTXSID2023567 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023567 TK.Half.Life NA 5.328 hours 1compartment NA NA Rat Human -DTXSID2023567 Css NA 0.553 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023567 Css NA 2.301 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023567 Css NA 0.3658 mg/L PBTK NA 50% Rat Human -DTXSID2023567 Css NA 1.438 mg/L PBTK NA 95% Rat Human -DTXSID2023569 Clint NA 19.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023569 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023569 Vd NA 0.3203 L/kg 1compartment NA NA Human Human +DTXSID2023567 TK.Half.Life NA 1.559 hours 1compartment NA NA Rat Human +DTXSID2023567 Css NA 0.03096 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023567 Css NA 0.1832 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023567 Css NA 0.0208 mg/L PBTK NA 50% Rat Human +DTXSID2023567 Css NA 0.1137 mg/L PBTK NA 95% Rat Human +DTXSID2023569 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023569 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023569 Vd NA 0.3624 L/kg 1compartment NA NA Human Human DTXSID2023569 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023569 TK.Half.Life NA 1.949 hours 1compartment NA NA Human Human -DTXSID2023569 Css NA 1.022 mg/L 3compartmentss NA 50% Human Human -DTXSID2023569 Css NA 7.67 mg/L 3compartmentss NA 95% Human Human -DTXSID2023569 Css NA 0.6103 mg/L PBTK NA 50% Human Human -DTXSID2023569 Css NA 4.495 mg/L PBTK NA 95% Human Human -DTXSID2023569 Clint NA 19.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023569 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023569 Vd NA 0.2848 L/kg 1compartment NA NA Rat Human +DTXSID2023569 TK.Half.Life NA 1.003 hours 1compartment NA NA Human Human +DTXSID2023569 Css NA 0.2599 mg/L 3compartmentss NA 50% Human Human +DTXSID2023569 Css NA 1.555 mg/L 3compartmentss NA 95% Human Human +DTXSID2023569 Css NA 0.1738 mg/L PBTK NA 50% Human Human +DTXSID2023569 Css NA 0.9789 mg/L PBTK NA 95% Human Human +DTXSID2023569 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023569 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023569 Vd NA 0.3792 L/kg 1compartment NA NA Rat Human DTXSID2023569 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023569 TK.Half.Life NA 1.107 hours 1compartment NA NA Rat Human -DTXSID2023569 Css NA 0.5714 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023569 Css NA 3.468 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023569 Css NA 0.3173 mg/L PBTK NA 50% Rat Human -DTXSID2023569 Css NA 1.885 mg/L PBTK NA 95% Rat Human -DTXSID2023640 Clint NA 94.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023640 Fup NA 0.0226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023640 Vd NA 3.126 L/kg 1compartment NA NA Human Human -DTXSID2023640 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2023640 TK.Half.Life NA 23.5 hours 1compartment NA NA Human Human -DTXSID2023640 Css NA 0.8046 mg/L 3compartmentss NA 50% Human Human -DTXSID2023640 Css NA 4.526 mg/L 3compartmentss NA 95% Human Human -DTXSID2023640 Css NA 0.5619 mg/L PBTK NA 50% Human Human -DTXSID2023640 Css NA 3.083 mg/L PBTK NA 95% Human Human -DTXSID2023640 Clint NA 94.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023640 Fup NA 0.0226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023640 Vd NA 2.342 L/kg 1compartment NA NA Rat Human -DTXSID2023640 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2023640 TK.Half.Life NA 3.522 hours 1compartment NA NA Rat Human -DTXSID2023640 Css NA 0.4568 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023640 Css NA 1.985 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023640 Css NA 0.303 mg/L PBTK NA 50% Rat Human -DTXSID2023640 Css NA 1.351 mg/L PBTK NA 95% Rat Human +DTXSID2023569 TK.Half.Life NA 0.6017 hours 1compartment NA NA Rat Human +DTXSID2023569 Css NA 0.03126 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023569 Css NA 0.1379 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023569 Css NA 0.02045 mg/L PBTK NA 50% Rat Human +DTXSID2023569 Css NA 0.08484 mg/L PBTK NA 95% Rat Human +DTXSID2023640 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023640 Fup 0.0315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023640 Vd NA 3.13 L/kg 1compartment NA NA Human Human +DTXSID2023640 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID2023640 TK.Half.Life NA 93.68 hours 1compartment NA NA Human Human +DTXSID2023640 Css NA 3.391 mg/L 3compartmentss NA 50% Human Human +DTXSID2023640 Css NA 19.98 mg/L 3compartmentss NA 95% Human Human +DTXSID2023640 Css NA 2.369 mg/L PBTK NA 50% Human Human +DTXSID2023640 Css NA 13.78 mg/L PBTK NA 95% Human Human +DTXSID2023640 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023640 Fup 0.0315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023640 Vd NA 2.345 L/kg 1compartment NA NA Rat Human +DTXSID2023640 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID2023640 TK.Half.Life NA 12.43 hours 1compartment NA NA Rat Human +DTXSID2023640 Css NA 0.447 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023640 Css NA 2.217 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023640 Css NA 0.3073 mg/L PBTK NA 50% Rat Human +DTXSID2023640 Css NA 1.552 mg/L PBTK NA 95% Rat Human DTXSID2023642 Clint 156.4 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.106.011569 NA Human Human -DTXSID2023642 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023642 Vd NA 2.736 L/kg 1compartment NA NA Human Human +DTXSID2023642 Fup 0.0772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023642 Vd NA 18.83 L/kg 1compartment NA NA Human Human DTXSID2023642 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023642 TK.Half.Life NA 3.117 hours 1compartment NA NA Human Human -DTXSID2023642 Css NA 0.0515 mg/L 3compartmentss NA 50% Human Human -DTXSID2023642 Css NA 0.4276 mg/L 3compartmentss NA 95% Human Human -DTXSID2023642 Css NA 0.0365 mg/L PBTK NA 50% Human Human -DTXSID2023642 Css NA 0.2754 mg/L PBTK NA 95% Human Human +DTXSID2023642 TK.Half.Life NA 10.79 hours 1compartment NA NA Human Human +DTXSID2023642 Css NA 0.01232 mg/L 3compartmentss NA 50% Human Human +DTXSID2023642 Css NA 0.09919 mg/L 3compartmentss NA 95% Human Human +DTXSID2023642 Css NA 0.02474 mg/L PBTK NA 50% Human Human +DTXSID2023642 Css NA 0.1646 mg/L PBTK NA 95% Human Human DTXSID2023642 Clint 156.4 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.106.011569 NA Rat Human -DTXSID2023642 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023642 Vd NA 2.175 L/kg 1compartment NA NA Rat Human +DTXSID2023642 Fup 0.0772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023642 Vd NA 15.32 L/kg 1compartment NA NA Rat Human DTXSID2023642 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023642 TK.Half.Life NA 1.027 hours 1compartment NA NA Rat Human -DTXSID2023642 Css NA 0.0288 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023642 Css NA 0.2085 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023642 Css NA 0.01936 mg/L PBTK NA 50% Rat Human -DTXSID2023642 Css NA 0.13 mg/L PBTK NA 95% Rat Human -DTXSID2023644 Clint NA 9.039 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023644 Fup NA 0.1621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023644 Vd NA 2.19 L/kg 1compartment NA NA Human Human -DTXSID2023644 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023644 TK.Half.Life NA 10.8 hours 1compartment NA NA Human Human -DTXSID2023644 Css NA 0.5474 mg/L 3compartmentss NA 50% Human Human -DTXSID2023644 Css NA 3.257 mg/L 3compartmentss NA 95% Human Human -DTXSID2023644 Css NA 0.3873 mg/L PBTK NA 50% Human Human -DTXSID2023644 Css NA 2.183 mg/L PBTK NA 95% Human Human -DTXSID2023644 Clint NA 9.039 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023644 Fup NA 0.1621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023644 Vd NA 1.671 L/kg 1compartment NA NA Rat Human +DTXSID2023642 TK.Half.Life NA 2.626 hours 1compartment NA NA Rat Human +DTXSID2023642 Css NA 0.00148 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023642 Css NA 0.0103 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023642 Css NA 0.003219 mg/L PBTK NA 50% Rat Human +DTXSID2023642 Css NA 0.01847 mg/L PBTK NA 95% Rat Human +DTXSID2023644 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023644 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023644 Vd NA 2.168 L/kg 1compartment NA NA Human Human +DTXSID2023644 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2023644 TK.Half.Life NA 16.56 hours 1compartment NA NA Human Human +DTXSID2023644 Css NA 1.071 mg/L 3compartmentss NA 50% Human Human +DTXSID2023644 Css NA 7.354 mg/L 3compartmentss NA 95% Human Human +DTXSID2023644 Css NA 0.7 mg/L PBTK NA 50% Human Human +DTXSID2023644 Css NA 4.631 mg/L PBTK NA 95% Human Human +DTXSID2023644 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023644 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023644 Vd NA 1.619 L/kg 1compartment NA NA Rat Human DTXSID2023644 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023644 TK.Half.Life NA 3.291 hours 1compartment NA NA Rat Human -DTXSID2023644 Css NA 0.2934 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023644 Css NA 1.284 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023644 Css NA 0.1982 mg/L PBTK NA 50% Rat Human -DTXSID2023644 Css NA 0.8108 mg/L PBTK NA 95% Rat Human -DTXSID2023690 Clint NA 22.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2023644 TK.Half.Life NA 4.976 hours 1compartment NA NA Rat Human +DTXSID2023644 Css NA 0.1378 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023644 Css NA 0.7603 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023644 Css NA 0.08805 mg/L PBTK NA 50% Rat Human +DTXSID2023644 Css NA 0.4767 mg/L PBTK NA 95% Rat Human +DTXSID2023648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023648 Fup 0.547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023648 Vd NA 0.474 L/kg 1compartment NA NA Human Human +DTXSID2023648 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023648 TK.Half.Life NA 5.608 hours 1compartment NA NA Human Human +DTXSID2023648 Css NA 1.37 mg/L 3compartmentss NA 50% Human Human +DTXSID2023648 Css NA 8.526 mg/L 3compartmentss NA 95% Human Human +DTXSID2023648 Css NA 1.017 mg/L PBTK NA 50% Human Human +DTXSID2023648 Css NA 5.308 mg/L PBTK NA 95% Human Human +DTXSID2023648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023648 Fup 0.547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023648 Vd NA 0.5118 L/kg 1compartment NA NA Rat Human +DTXSID2023648 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2023648 TK.Half.Life NA 2.062 hours 1compartment NA NA Rat Human +DTXSID2023648 Css NA 0.08513 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023648 Css NA 0.4753 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023648 Css NA 0.0623 mg/L PBTK NA 50% Rat Human +DTXSID2023648 Css NA 0.2838 mg/L PBTK NA 95% Rat Human +DTXSID20236667 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20236667 Fup 0.34 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20236667 Vd NA 1.706 L/kg 1compartment NA NA Human Human +DTXSID20236667 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20236667 TK.Half.Life NA 4.725 hours 1compartment NA NA Human Human +DTXSID20236667 Css NA 0.2378 mg/L 3compartmentss NA 50% Human Human +DTXSID20236667 Css NA 1.505 mg/L 3compartmentss NA 95% Human Human +DTXSID20236667 Css NA 0.1838 mg/L PBTK NA 50% Human Human +DTXSID20236667 Css NA 1.044 mg/L PBTK NA 95% Human Human +DTXSID20236667 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20236667 Fup 0.34 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20236667 Vd NA 1.364 L/kg 1compartment NA NA Rat Human +DTXSID20236667 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20236667 TK.Half.Life NA 1.79 hours 1compartment NA NA Rat Human +DTXSID20236667 Css NA 0.02784 mg/L 3compartmentss NA 50% Rat Human +DTXSID20236667 Css NA 0.1261 mg/L 3compartmentss NA 95% Rat Human +DTXSID20236667 Css NA 0.02155 mg/L PBTK NA 50% Rat Human +DTXSID20236667 Css NA 0.08629 mg/L PBTK NA 95% Rat Human +DTXSID2023690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2023690 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2023690 Vd NA 0.2666 L/kg 1compartment NA NA Human Human DTXSID2023690 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023690 TK.Half.Life NA 4.435 hours 1compartment NA NA Human Human -DTXSID2023690 Css NA 3.034 mg/L 3compartmentss NA 50% Human Human -DTXSID2023690 Css NA 30.78 mg/L 3compartmentss NA 95% Human Human -DTXSID2023690 Css NA 1.77 mg/L PBTK NA 50% Human Human -DTXSID2023690 Css NA 17.59 mg/L PBTK NA 95% Human Human -DTXSID2023690 Clint NA 22.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2023690 TK.Half.Life NA 4.646 hours 1compartment NA NA Human Human +DTXSID2023690 Css NA 3.092 mg/L 3compartmentss NA 50% Human Human +DTXSID2023690 Css NA 31.09 mg/L 3compartmentss NA 95% Human Human +DTXSID2023690 Css NA 1.822 mg/L PBTK NA 50% Human Human +DTXSID2023690 Css NA 18.05 mg/L PBTK NA 95% Human Human +DTXSID2023690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2023690 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2023690 Vd NA 0.2288 L/kg 1compartment NA NA Rat Human DTXSID2023690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023690 TK.Half.Life NA 2.536 hours 1compartment NA NA Rat Human -DTXSID2023690 Css NA 1.732 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023690 Css NA 13.58 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023690 Css NA 0.9476 mg/L PBTK NA 50% Rat Human -DTXSID2023690 Css NA 7.371 mg/L PBTK NA 95% Rat Human -DTXSID2023692 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2023690 TK.Half.Life NA 2.657 hours 1compartment NA NA Rat Human +DTXSID2023690 Css NA 0.4095 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023690 Css NA 3.408 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023690 Css NA 0.2318 mg/L PBTK NA 50% Rat Human +DTXSID2023690 Css NA 1.912 mg/L PBTK NA 95% Rat Human +DTXSID2023692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2023692 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023692 Vd NA 0.56 L/kg 1compartment NA NA Human Human -DTXSID2023692 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2023692 TK.Half.Life NA 21.85 hours 1compartment NA NA Human Human -DTXSID2023692 Css NA 4.892 mg/L 3compartmentss NA 50% Human Human -DTXSID2023692 Css NA 18.39 mg/L 3compartmentss NA 95% Human Human -DTXSID2023692 Css NA 3.226 mg/L PBTK NA 50% Human Human -DTXSID2023692 Css NA 11.1 mg/L PBTK NA 95% Human Human -DTXSID2023692 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2023692 Vd NA 2.244 L/kg 1compartment NA NA Human Human +DTXSID2023692 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023692 TK.Half.Life NA 5.835 hours 1compartment NA NA Human Human +DTXSID2023692 Css NA 0.2231 mg/L 3compartmentss NA 50% Human Human +DTXSID2023692 Css NA 1.453 mg/L 3compartmentss NA 95% Human Human +DTXSID2023692 Css NA 0.1593 mg/L PBTK NA 50% Human Human +DTXSID2023692 Css NA 0.9635 mg/L PBTK NA 95% Human Human +DTXSID2023692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2023692 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023692 Vd NA 0.494 L/kg 1compartment NA NA Rat Human +DTXSID2023692 Vd NA 1.702 L/kg 1compartment NA NA Rat Human DTXSID2023692 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023692 TK.Half.Life NA 6.442 hours 1compartment NA NA Rat Human -DTXSID2023692 Css NA 1.366 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023692 Css NA 4.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023692 Css NA 0.8485 mg/L PBTK NA 50% Rat Human -DTXSID2023692 Css NA 2.378 mg/L PBTK NA 95% Rat Human -DTXSID2023721 Clint NA 413.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023721 Fup NA 0.1985 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023721 Vd NA 3.291 L/kg 1compartment NA NA Human Human +DTXSID2023692 TK.Half.Life NA 1.77 hours 1compartment NA NA Rat Human +DTXSID2023692 Css NA 0.02841 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023692 Css NA 0.1416 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023692 Css NA 0.02005 mg/L PBTK NA 50% Rat Human +DTXSID2023692 Css NA 0.09528 mg/L PBTK NA 95% Rat Human +DTXSID2023721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023721 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023721 Vd NA 1.453 L/kg 1compartment NA NA Human Human DTXSID2023721 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023721 TK.Half.Life NA 2.296 hours 1compartment NA NA Human Human -DTXSID2023721 Css NA 0.007135 mg/L 3compartmentss NA 50% Human Human -DTXSID2023721 Css NA 0.04982 mg/L 3compartmentss NA 95% Human Human -DTXSID2023721 Css NA 0.006228 mg/L PBTK NA 50% Human Human -DTXSID2023721 Css NA 0.04064 mg/L PBTK NA 95% Human Human -DTXSID2023721 Clint NA 413.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023721 Fup NA 0.1985 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023721 Vd NA 2.852 L/kg 1compartment NA NA Rat Human +DTXSID2023721 TK.Half.Life NA 2.965 hours 1compartment NA NA Human Human +DTXSID2023721 Css NA 0.1437 mg/L 3compartmentss NA 50% Human Human +DTXSID2023721 Css NA 1.051 mg/L 3compartmentss NA 95% Human Human +DTXSID2023721 Css NA 0.09988 mg/L PBTK NA 50% Human Human +DTXSID2023721 Css NA 0.6974 mg/L PBTK NA 95% Human Human +DTXSID2023721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023721 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023721 Vd NA 1.124 L/kg 1compartment NA NA Rat Human DTXSID2023721 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023721 TK.Half.Life NA 0.8565 hours 1compartment NA NA Rat Human -DTXSID2023721 Css NA 0.00391 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023721 Css NA 0.02396 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023721 Css NA 0.00337 mg/L PBTK NA 50% Rat Human -DTXSID2023721 Css NA 0.0193 mg/L PBTK NA 95% Rat Human +DTXSID2023721 TK.Half.Life NA 1.146 hours 1compartment NA NA Rat Human +DTXSID2023721 Css NA 0.00688 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023721 Css NA 0.05553 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023721 Css NA 0.00474 mg/L PBTK NA 50% Rat Human +DTXSID2023721 Css NA 0.03445 mg/L PBTK NA 95% Rat Human DTXSID2023723 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2023723 Fup NA 0.9444 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023723 Vd NA 1.5 L/kg 1compartment NA NA Human Human +DTXSID2023723 Vd NA 2.571 L/kg 1compartment NA NA Human Human DTXSID2023723 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2023723 TK.Half.Life NA 10.27 hours 1compartment NA NA Human Human -DTXSID2023723 Css NA 0.736 mg/L 3compartmentss NA 50% Human Human -DTXSID2023723 Css NA 2.823 mg/L 3compartmentss NA 95% Human Human -DTXSID2023723 Css NA 0.7127 mg/L PBTK NA 50% Human Human -DTXSID2023723 Css NA 2.141 mg/L PBTK NA 95% Human Human +DTXSID2023723 TK.Half.Life NA 17.63 hours 1compartment NA NA Human Human +DTXSID2023723 Css NA 0.5452 mg/L 3compartmentss NA 50% Human Human +DTXSID2023723 Css NA 2.282 mg/L 3compartmentss NA 95% Human Human +DTXSID2023723 Css NA 0.6061 mg/L PBTK NA 50% Human Human +DTXSID2023723 Css NA 1.873 mg/L PBTK NA 95% Human Human DTXSID2023723 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2023723 Fup NA 0.9444 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023723 Vd NA 1.55 L/kg 1compartment NA NA Rat Human +DTXSID2023723 Vd NA 2.615 L/kg 1compartment NA NA Rat Human DTXSID2023723 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023723 TK.Half.Life NA 3.62 hours 1compartment NA NA Rat Human -DTXSID2023723 Css NA 0.1886 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023723 Css NA 0.672 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023723 Css NA 0.1807 mg/L PBTK NA 50% Rat Human -DTXSID2023723 Css NA 0.4707 mg/L PBTK NA 95% Rat Human -DTXSID2023725 Clint NA 166.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023725 Fup NA 0.5396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023725 Vd NA 2.304 L/kg 1compartment NA NA Human Human +DTXSID2023723 TK.Half.Life NA 6.107 hours 1compartment NA NA Rat Human +DTXSID2023723 Css NA 0.009786 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023723 Css NA 0.05468 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023723 Css NA 0.01075 mg/L PBTK NA 50% Rat Human +DTXSID2023723 Css NA 0.04995 mg/L PBTK NA 95% Rat Human +DTXSID2023725 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023725 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023725 Vd NA 2.52 L/kg 1compartment NA NA Human Human DTXSID2023725 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023725 TK.Half.Life NA 1.233 hours 1compartment NA NA Human Human -DTXSID2023725 Css NA 0.003958 mg/L 3compartmentss NA 50% Human Human -DTXSID2023725 Css NA 0.04594 mg/L 3compartmentss NA 95% Human Human -DTXSID2023725 Css NA 0.004096 mg/L PBTK NA 50% Human Human -DTXSID2023725 Css NA 0.03708 mg/L PBTK NA 95% Human Human -DTXSID2023725 Clint NA 166.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023725 Fup NA 0.5396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023725 Vd NA 2.322 L/kg 1compartment NA NA Rat Human +DTXSID2023725 TK.Half.Life NA 3.36 hours 1compartment NA NA Human Human +DTXSID2023725 Css NA 0.07115 mg/L 3compartmentss NA 50% Human Human +DTXSID2023725 Css NA 0.8036 mg/L 3compartmentss NA 95% Human Human +DTXSID2023725 Css NA 0.07638 mg/L PBTK NA 50% Human Human +DTXSID2023725 Css NA 0.619 mg/L PBTK NA 95% Human Human +DTXSID2023725 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023725 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023725 Vd NA 2.544 L/kg 1compartment NA NA Rat Human DTXSID2023725 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023725 TK.Half.Life NA 0.5617 hours 1compartment NA NA Rat Human -DTXSID2023725 Css NA 0.002076 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023725 Css NA 0.02172 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023725 Css NA 0.002138 mg/L PBTK NA 50% Rat Human -DTXSID2023725 Css NA 0.0167 mg/L PBTK NA 95% Rat Human -DTXSID2023727 Clint NA 0.7887 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2023725 TK.Half.Life NA 1.905 hours 1compartment NA NA Rat Human +DTXSID2023725 Css NA 0.003024 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023725 Css NA 0.03592 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023725 Css NA 0.003486 mg/L PBTK NA 50% Rat Human +DTXSID2023725 Css NA 0.02794 mg/L PBTK NA 95% Rat Human +DTXSID2023727 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2023727 Fup 0.58 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2023727 Vd NA 3.202 L/kg 1compartment NA NA Human Human -DTXSID2023727 Days.Css NA 103 Days PBTK NA NA Human Human -DTXSID2023727 TK.Half.Life NA 446.9 hours 1compartment NA NA Human Human -DTXSID2023727 Css NA 16.72 mg/L 3compartmentss NA 50% Human Human -DTXSID2023727 Css NA 99.16 mg/L 3compartmentss NA 95% Human Human -DTXSID2023727 Css NA 11.8 mg/L PBTK NA 50% Human Human -DTXSID2023727 Css NA 67.43 mg/L PBTK NA 95% Human Human -DTXSID2023727 Clint NA 0.7887 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2023727 Vd NA 5.491 L/kg 1compartment NA NA Human Human +DTXSID2023727 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2023727 TK.Half.Life NA 31.9 hours 1compartment NA NA Human Human +DTXSID2023727 Css NA 0.5038 mg/L 3compartmentss NA 50% Human Human +DTXSID2023727 Css NA 3.421 mg/L 3compartmentss NA 95% Human Human +DTXSID2023727 Css NA 0.43 mg/L PBTK NA 50% Human Human +DTXSID2023727 Css NA 2.742 mg/L PBTK NA 95% Human Human +DTXSID2023727 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2023727 Fup 0.58 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2023727 Vd NA 2.422 L/kg 1compartment NA NA Rat Human -DTXSID2023727 Days.Css NA 56 Days PBTK NA NA Rat Human -DTXSID2023727 TK.Half.Life NA 56.31 hours 1compartment NA NA Rat Human -DTXSID2023727 Css NA 9.32 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023727 Css NA 42.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023727 Css NA 6.32 mg/L PBTK NA 50% Rat Human -DTXSID2023727 Css NA 27.92 mg/L PBTK NA 95% Rat Human +DTXSID2023727 Vd NA 4.23 L/kg 1compartment NA NA Rat Human +DTXSID2023727 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2023727 TK.Half.Life NA 4.881 hours 1compartment NA NA Rat Human +DTXSID2023727 Css NA 0.06379 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023727 Css NA 0.3741 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023727 Css NA 0.05542 mg/L PBTK NA 50% Rat Human +DTXSID2023727 Css NA 0.3081 mg/L PBTK NA 95% Rat Human DTXSID2023729 Clint NA 11.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2023729 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023729 Vd NA 0.2909 L/kg 1compartment NA NA Human Human +DTXSID2023729 Vd NA 0.2695 L/kg 1compartment NA NA Human Human DTXSID2023729 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023729 TK.Half.Life NA 8.284 hours 1compartment NA NA Human Human -DTXSID2023729 Css NA 5.117 mg/L 3compartmentss NA 50% Human Human -DTXSID2023729 Css NA 48.35 mg/L 3compartmentss NA 95% Human Human -DTXSID2023729 Css NA 3.079 mg/L PBTK NA 50% Human Human -DTXSID2023729 Css NA 28.42 mg/L PBTK NA 95% Human Human +DTXSID2023729 TK.Half.Life NA 7.745 hours 1compartment NA NA Human Human +DTXSID2023729 Css NA 5.041 mg/L 3compartmentss NA 50% Human Human +DTXSID2023729 Css NA 47.07 mg/L 3compartmentss NA 95% Human Human +DTXSID2023729 Css NA 3.026 mg/L PBTK NA 50% Human Human +DTXSID2023729 Css NA 27.7 mg/L PBTK NA 95% Human Human DTXSID2023729 Clint NA 11.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2023729 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023729 Vd NA 0.2731 L/kg 1compartment NA NA Rat Human +DTXSID2023729 Vd NA 0.2558 L/kg 1compartment NA NA Rat Human DTXSID2023729 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023729 TK.Half.Life NA 5.131 hours 1compartment NA NA Rat Human -DTXSID2023729 Css NA 2.869 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023729 Css NA 21.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023729 Css NA 1.616 mg/L PBTK NA 50% Rat Human -DTXSID2023729 Css NA 11.83 mg/L PBTK NA 95% Rat Human -DTXSID2023771 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023771 Fup NA 0.7254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023771 Vd NA 0.7348 L/kg 1compartment NA NA Human Human +DTXSID2023729 TK.Half.Life NA 4.844 hours 1compartment NA NA Rat Human +DTXSID2023729 Css NA 0.6594 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023729 Css NA 4.952 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023729 Css NA 0.3804 mg/L PBTK NA 50% Rat Human +DTXSID2023729 Css NA 2.802 mg/L PBTK NA 95% Rat Human +DTXSID2023771 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023771 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023771 Vd NA 0.7254 L/kg 1compartment NA NA Human Human DTXSID2023771 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2023771 TK.Half.Life NA 6.576 hours 1compartment NA NA Human Human -DTXSID2023771 Css NA 1.059 mg/L 3compartmentss NA 50% Human Human -DTXSID2023771 Css NA 6.607 mg/L 3compartmentss NA 95% Human Human -DTXSID2023771 Css NA 0.8662 mg/L PBTK NA 50% Human Human -DTXSID2023771 Css NA 4.202 mg/L PBTK NA 95% Human Human -DTXSID2023771 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023771 Fup NA 0.7254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023771 Vd NA 0.7513 L/kg 1compartment NA NA Rat Human +DTXSID2023771 TK.Half.Life NA 6.633 hours 1compartment NA NA Human Human +DTXSID2023771 Css NA 1.041 mg/L 3compartmentss NA 50% Human Human +DTXSID2023771 Css NA 6.911 mg/L 3compartmentss NA 95% Human Human +DTXSID2023771 Css NA 0.8523 mg/L PBTK NA 50% Human Human +DTXSID2023771 Css NA 4.372 mg/L PBTK NA 95% Human Human +DTXSID2023771 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023771 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023771 Vd NA 0.7417 L/kg 1compartment NA NA Rat Human DTXSID2023771 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2023771 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human -DTXSID2023771 Css NA 0.2733 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023771 Css NA 1.717 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023771 Css NA 0.2162 mg/L PBTK NA 50% Rat Human -DTXSID2023771 Css NA 1.019 mg/L PBTK NA 95% Rat Human -DTXSID2023775 Clint NA 0.6125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023775 Fup NA 0.083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2023775 Vd NA 0.9702 L/kg 1compartment NA NA Human Human -DTXSID2023775 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID2023775 TK.Half.Life NA 40.56 hours 1compartment NA NA Human Human -DTXSID2023775 Css NA 6.387 mg/L 3compartmentss NA 50% Human Human -DTXSID2023775 Css NA 30.95 mg/L 3compartmentss NA 95% Human Human -DTXSID2023775 Css NA 4.094 mg/L PBTK NA 50% Human Human -DTXSID2023775 Css NA 18.39 mg/L PBTK NA 95% Human Human -DTXSID2023775 Clint NA 0.6125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023775 Fup NA 0.083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2023775 Vd NA 0.7587 L/kg 1compartment NA NA Rat Human -DTXSID2023775 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2023775 TK.Half.Life NA 13.47 hours 1compartment NA NA Rat Human -DTXSID2023775 Css NA 2.468 mg/L 3compartmentss NA 50% Rat Human -DTXSID2023775 Css NA 9.772 mg/L 3compartmentss NA 95% Rat Human -DTXSID2023775 Css NA 1.478 mg/L PBTK NA 50% Rat Human -DTXSID2023775 Css NA 5.455 mg/L PBTK NA 95% Rat Human -DTXSID2024038 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024038 Fup NA 0.7626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024038 Vd NA 1.048 L/kg 1compartment NA NA Human Human +DTXSID2023771 TK.Half.Life NA 2.304 hours 1compartment NA NA Rat Human +DTXSID2023771 Css NA 0.06206 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023771 Css NA 0.4061 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023771 Css NA 0.05078 mg/L PBTK NA 50% Rat Human +DTXSID2023771 Css NA 0.2486 mg/L PBTK NA 95% Rat Human +DTXSID2023775 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023775 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2023775 Vd NA 1.04 L/kg 1compartment NA NA Human Human +DTXSID2023775 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2023775 TK.Half.Life NA 2.197 hours 1compartment NA NA Human Human +DTXSID2023775 Css NA 0.1931 mg/L 3compartmentss NA 50% Human Human +DTXSID2023775 Css NA 1.505 mg/L 3compartmentss NA 95% Human Human +DTXSID2023775 Css NA 0.129 mg/L PBTK NA 50% Human Human +DTXSID2023775 Css NA 0.94 mg/L PBTK NA 95% Human Human +DTXSID2023775 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023775 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2023775 Vd NA 0.8319 L/kg 1compartment NA NA Rat Human +DTXSID2023775 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2023775 TK.Half.Life NA 0.9537 hours 1compartment NA NA Rat Human +DTXSID2023775 Css NA 0.02464 mg/L 3compartmentss NA 50% Rat Human +DTXSID2023775 Css NA 0.1529 mg/L 3compartmentss NA 95% Rat Human +DTXSID2023775 Css NA 0.01605 mg/L PBTK NA 50% Rat Human +DTXSID2023775 Css NA 0.09286 mg/L PBTK NA 95% Rat Human +DTXSID2024038 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024038 Fup 0.763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024038 Vd NA 0.9019 L/kg 1compartment NA NA Human Human DTXSID2024038 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024038 TK.Half.Life NA 9.189 hours 1compartment NA NA Human Human -DTXSID2024038 Css NA 0.9758 mg/L 3compartmentss NA 50% Human Human -DTXSID2024038 Css NA 6.232 mg/L 3compartmentss NA 95% Human Human -DTXSID2024038 Css NA 0.8533 mg/L PBTK NA 50% Human Human -DTXSID2024038 Css NA 4.117 mg/L PBTK NA 95% Human Human -DTXSID2024038 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024038 Fup NA 0.7626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024038 Vd NA 1.003 L/kg 1compartment NA NA Rat Human +DTXSID2024038 TK.Half.Life NA 0.7095 hours 1compartment NA NA Human Human +DTXSID2024038 Css NA 0.02073 mg/L 3compartmentss NA 50% Human Human +DTXSID2024038 Css NA 0.2504 mg/L 3compartmentss NA 95% Human Human +DTXSID2024038 Css NA 0.01731 mg/L PBTK NA 50% Human Human +DTXSID2024038 Css NA 0.1797 mg/L PBTK NA 95% Human Human +DTXSID2024038 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024038 Fup 0.763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024038 Vd NA 0.8915 L/kg 1compartment NA NA Rat Human DTXSID2024038 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024038 TK.Half.Life NA 2.922 hours 1compartment NA NA Rat Human -DTXSID2024038 Css NA 0.2514 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024038 Css NA 1.633 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024038 Css NA 0.2134 mg/L PBTK NA 50% Rat Human -DTXSID2024038 Css NA 0.9906 mg/L PBTK NA 95% Rat Human +DTXSID2024038 TK.Half.Life NA 0.3413 hours 1compartment NA NA Rat Human +DTXSID2024038 Css NA 0.0007545 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024038 Css NA 0.01029 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024038 Css NA 0.0006244 mg/L PBTK NA 50% Rat Human +DTXSID2024038 Css NA 0.006922 mg/L PBTK NA 95% Rat Human +DTXSID20240825 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20240825 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20240825 Vd NA 0.9104 L/kg 1compartment NA NA Human Human +DTXSID20240825 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID20240825 TK.Half.Life NA 12.52 hours 1compartment NA NA Human Human +DTXSID20240825 Css NA 1.415 mg/L 3compartmentss NA 50% Human Human +DTXSID20240825 Css NA 7.061 mg/L 3compartmentss NA 95% Human Human +DTXSID20240825 Css NA 1.133 mg/L PBTK NA 50% Human Human +DTXSID20240825 Css NA 4.623 mg/L PBTK NA 95% Human Human +DTXSID20240825 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20240825 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20240825 Vd NA 0.8732 L/kg 1compartment NA NA Rat Human +DTXSID20240825 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20240825 TK.Half.Life NA 4.025 hours 1compartment NA NA Rat Human +DTXSID20240825 Css NA 0.08809 mg/L 3compartmentss NA 50% Rat Human +DTXSID20240825 Css NA 0.3991 mg/L 3compartmentss NA 95% Rat Human +DTXSID20240825 Css NA 0.0706 mg/L PBTK NA 50% Rat Human +DTXSID20240825 Css NA 0.2505 mg/L PBTK NA 95% Rat Human DTXSID2024086 Clint 10.41 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID2024086 Fup 2.03e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2024086 Vd NA 0.7016 L/kg 1compartment NA NA Human Human -DTXSID2024086 Days.Css NA 82 Days PBTK NA NA Human Human +DTXSID2024086 Days.Css NA 81 Days PBTK NA NA Human Human DTXSID2024086 TK.Half.Life NA 332 hours 1compartment NA NA Human Human -DTXSID2024086 Css NA 36.46 mg/L 3compartmentss NA 50% Human Human -DTXSID2024086 Css NA 223.9 mg/L 3compartmentss NA 95% Human Human -DTXSID2024086 Css NA 21.98 mg/L PBTK NA 50% Human Human -DTXSID2024086 Css NA 131.6 mg/L PBTK NA 95% Human Human +DTXSID2024086 Css NA 36.21 mg/L 3compartmentss NA 50% Human Human +DTXSID2024086 Css NA 231.8 mg/L 3compartmentss NA 95% Human Human +DTXSID2024086 Css NA 21.76 mg/L PBTK NA 50% Human Human +DTXSID2024086 Css NA 137.2 mg/L PBTK NA 95% Human Human DTXSID2024086 Clint 10.41 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID2024086 Fup 2.03e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2024086 Vd NA 0.5121 L/kg 1compartment NA NA Rat Human DTXSID2024086 Days.Css NA 39 Days PBTK NA NA Rat Human DTXSID2024086 TK.Half.Life NA 168.8 hours 1compartment NA NA Rat Human -DTXSID2024086 Css NA 24.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024086 Css NA 90.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024086 Css NA 13.77 mg/L PBTK NA 50% Rat Human -DTXSID2024086 Css NA 50.5 mg/L PBTK NA 95% Rat Human -DTXSID2024113 Clint NA 11.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024113 Fup NA 0.0472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024113 Vd NA 2.628 L/kg 1compartment NA NA Human Human -DTXSID2024113 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2024113 TK.Half.Life NA 37.21 hours 1compartment NA NA Human Human -DTXSID2024113 Css NA 1.892 mg/L 3compartmentss NA 50% Human Human -DTXSID2024113 Css NA 11.86 mg/L 3compartmentss NA 95% Human Human -DTXSID2024113 Css NA 1.28 mg/L PBTK NA 50% Human Human -DTXSID2024113 Css NA 7.712 mg/L PBTK NA 95% Human Human -DTXSID2024113 Clint NA 11.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024113 Fup NA 0.0472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024113 Vd NA 1.969 L/kg 1compartment NA NA Rat Human -DTXSID2024113 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2024113 TK.Half.Life NA 8.368 hours 1compartment NA NA Rat Human -DTXSID2024113 Css NA 1.064 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024113 Css NA 5.399 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024113 Css NA 0.6818 mg/L PBTK NA 50% Rat Human -DTXSID2024113 Css NA 3.308 mg/L PBTK NA 95% Rat Human +DTXSID2024086 Css NA 5.582 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024086 Css NA 20.85 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024086 Css NA 3.208 mg/L PBTK NA 50% Rat Human +DTXSID2024086 Css NA 11.97 mg/L PBTK NA 95% Rat Human +DTXSID2024113 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024113 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024113 Vd NA 1.855 L/kg 1compartment NA NA Human Human +DTXSID2024113 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2024113 TK.Half.Life NA 25.2 hours 1compartment NA NA Human Human +DTXSID2024113 Css NA 2.106 mg/L 3compartmentss NA 50% Human Human +DTXSID2024113 Css NA 18.13 mg/L 3compartmentss NA 95% Human Human +DTXSID2024113 Css NA 1.339 mg/L PBTK NA 50% Human Human +DTXSID2024113 Css NA 10.91 mg/L PBTK NA 95% Human Human +DTXSID2024113 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024113 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024113 Vd NA 1.373 L/kg 1compartment NA NA Rat Human +DTXSID2024113 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2024113 TK.Half.Life NA 8.574 hours 1compartment NA NA Rat Human +DTXSID2024113 Css NA 0.2721 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024113 Css NA 1.844 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024113 Css NA 0.1679 mg/L PBTK NA 50% Rat Human +DTXSID2024113 Css NA 1.093 mg/L PBTK NA 95% Rat Human +DTXSID20241458 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20241458 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20241458 Vd NA 0.247 L/kg 1compartment NA NA Human Human +DTXSID20241458 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID20241458 TK.Half.Life NA 31.99 hours 1compartment NA NA Human Human +DTXSID20241458 Css NA 21.02 mg/L 3compartmentss NA 50% Human Human +DTXSID20241458 Css NA 103.2 mg/L 3compartmentss NA 95% Human Human +DTXSID20241458 Css NA 12.62 mg/L PBTK NA 50% Human Human +DTXSID20241458 Css NA 60.1 mg/L PBTK NA 95% Human Human +DTXSID20241458 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20241458 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20241458 Vd NA 0.2401 L/kg 1compartment NA NA Rat Human +DTXSID20241458 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID20241458 TK.Half.Life NA 10.59 hours 1compartment NA NA Rat Human +DTXSID20241458 Css NA 1.381 mg/L 3compartmentss NA 50% Rat Human +DTXSID20241458 Css NA 5.727 mg/L 3compartmentss NA 95% Rat Human +DTXSID20241458 Css NA 0.798 mg/L PBTK NA 50% Rat Human +DTXSID20241458 Css NA 3.229 mg/L PBTK NA 95% Rat Human DTXSID2024163 Clint 33.05 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2024163 Fup 0.1051 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2024163 Vd NA 2.211 L/kg 1compartment NA NA Human Human DTXSID2024163 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2024163 TK.Half.Life NA 5.762 hours 1compartment NA NA Human Human -DTXSID2024163 Css NA 0.2613 mg/L 3compartmentss NA 50% Human Human -DTXSID2024163 Css NA 1.82 mg/L 3compartmentss NA 95% Human Human -DTXSID2024163 Css NA 0.1784 mg/L PBTK NA 50% Human Human -DTXSID2024163 Css NA 1.172 mg/L PBTK NA 95% Human Human +DTXSID2024163 Css NA 0.2542 mg/L 3compartmentss NA 50% Human Human +DTXSID2024163 Css NA 1.785 mg/L 3compartmentss NA 95% Human Human +DTXSID2024163 Css NA 0.1736 mg/L PBTK NA 50% Human Human +DTXSID2024163 Css NA 1.16 mg/L PBTK NA 95% Human Human DTXSID2024163 Clint 33.05 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2024163 Fup 0.1051 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2024163 Vd NA 1.672 L/kg 1compartment NA NA Rat Human DTXSID2024163 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2024163 TK.Half.Life NA 1.784 hours 1compartment NA NA Rat Human -DTXSID2024163 Css NA 0.1463 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024163 Css NA 0.8148 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024163 Css NA 0.09504 mg/L PBTK NA 50% Rat Human -DTXSID2024163 Css NA 0.5049 mg/L PBTK NA 95% Rat Human +DTXSID2024163 Css NA 0.0327 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024163 Css NA 0.1954 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024163 Css NA 0.022 mg/L PBTK NA 50% Rat Human +DTXSID2024163 Css NA 0.1249 mg/L PBTK NA 95% Rat Human DTXSID2024242 Clint 7.14 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2024242 Fup 0.1538 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2024242 Vd NA 2.443 L/kg 1compartment NA NA Human Human DTXSID2024242 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID2024242 TK.Half.Life NA 18.47 hours 1compartment NA NA Human Human -DTXSID2024242 Css NA 0.9108 mg/L 3compartmentss NA 50% Human Human -DTXSID2024242 Css NA 5.018 mg/L 3compartmentss NA 95% Human Human -DTXSID2024242 Css NA 0.6428 mg/L PBTK NA 50% Human Human -DTXSID2024242 Css NA 3.36 mg/L PBTK NA 95% Human Human +DTXSID2024242 Css NA 0.881 mg/L 3compartmentss NA 50% Human Human +DTXSID2024242 Css NA 5.138 mg/L 3compartmentss NA 95% Human Human +DTXSID2024242 Css NA 0.6231 mg/L PBTK NA 50% Human Human +DTXSID2024242 Css NA 3.473 mg/L PBTK NA 95% Human Human DTXSID2024242 Clint 7.14 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2024242 Fup 0.1538 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2024242 Vd NA 1.854 L/kg 1compartment NA NA Rat Human DTXSID2024242 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2024242 TK.Half.Life NA 4.81 hours 1compartment NA NA Rat Human -DTXSID2024242 Css NA 0.4767 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024242 Css NA 2.038 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024242 Css NA 0.3222 mg/L PBTK NA 50% Rat Human -DTXSID2024242 Css NA 1.285 mg/L PBTK NA 95% Rat Human -DTXSID2024452 Clint NA 0.4344 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024452 Fup NA 0.7186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024452 Vd NA 0.7313 L/kg 1compartment NA NA Human Human +DTXSID2024242 Css NA 0.1084 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024242 Css NA 0.4493 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024242 Css NA 0.07554 mg/L PBTK NA 50% Rat Human +DTXSID2024242 Css NA 0.2988 mg/L PBTK NA 95% Rat Human +DTXSID2024452 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024452 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024452 Vd NA 0.5619 L/kg 1compartment NA NA Human Human DTXSID2024452 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024452 TK.Half.Life NA 3.923 hours 1compartment NA NA Human Human -DTXSID2024452 Css NA 0.6094 mg/L 3compartmentss NA 50% Human Human -DTXSID2024452 Css NA 3.871 mg/L 3compartmentss NA 95% Human Human -DTXSID2024452 Css NA 0.498 mg/L PBTK NA 50% Human Human -DTXSID2024452 Css NA 2.514 mg/L PBTK NA 95% Human Human -DTXSID2024452 Clint NA 0.4344 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024452 Fup NA 0.7186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024452 Vd NA 0.7474 L/kg 1compartment NA NA Rat Human +DTXSID2024452 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human +DTXSID2024452 Css NA 0.763 mg/L 3compartmentss NA 50% Human Human +DTXSID2024452 Css NA 4.479 mg/L 3compartmentss NA 95% Human Human +DTXSID2024452 Css NA 0.5832 mg/L PBTK NA 50% Human Human +DTXSID2024452 Css NA 2.792 mg/L PBTK NA 95% Human Human +DTXSID2024452 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024452 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024452 Vd NA 0.5819 L/kg 1compartment NA NA Rat Human DTXSID2024452 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024452 TK.Half.Life NA 1.715 hours 1compartment NA NA Rat Human -DTXSID2024452 Css NA 0.2031 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024452 Css NA 1.302 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024452 Css NA 0.1612 mg/L PBTK NA 50% Rat Human -DTXSID2024452 Css NA 0.7738 mg/L PBTK NA 95% Rat Human -DTXSID2024454 Clint NA 0.5582 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024454 Fup NA 0.9332 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024454 Vd NA 1.044 L/kg 1compartment NA NA Human Human +DTXSID2024452 TK.Half.Life NA 2.436 hours 1compartment NA NA Rat Human +DTXSID2024452 Css NA 0.004018 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024452 Css NA 0.02404 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024452 Css NA 0.002942 mg/L PBTK NA 50% Rat Human +DTXSID2024452 Css NA 0.01454 mg/L PBTK NA 95% Rat Human +DTXSID2024454 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024454 Fup 0.552 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024454 Vd NA 0.7651 L/kg 1compartment NA NA Human Human DTXSID2024454 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024454 TK.Half.Life NA 3.959 hours 1compartment NA NA Human Human -DTXSID2024454 Css NA 0.4202 mg/L 3compartmentss NA 50% Human Human -DTXSID2024454 Css NA 1.67 mg/L 3compartmentss NA 95% Human Human -DTXSID2024454 Css NA 0.3727 mg/L PBTK NA 50% Human Human -DTXSID2024454 Css NA 1.218 mg/L PBTK NA 95% Human Human -DTXSID2024454 Clint NA 0.5582 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024454 Fup NA 0.9332 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024454 Vd NA 1.029 L/kg 1compartment NA NA Rat Human +DTXSID2024454 TK.Half.Life NA 0.7208 hours 1compartment NA NA Human Human +DTXSID2024454 Css NA 0.03575 mg/L 3compartmentss NA 50% Human Human +DTXSID2024454 Css NA 0.3957 mg/L 3compartmentss NA 95% Human Human +DTXSID2024454 Css NA 0.02806 mg/L PBTK NA 50% Human Human +DTXSID2024454 Css NA 0.2648 mg/L PBTK NA 95% Human Human +DTXSID2024454 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024454 Fup 0.552 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024454 Vd NA 0.7501 L/kg 1compartment NA NA Rat Human DTXSID2024454 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024454 TK.Half.Life NA 1.708 hours 1compartment NA NA Rat Human -DTXSID2024454 Css NA 0.1423 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024454 Css NA 0.5122 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024454 Css NA 0.1255 mg/L PBTK NA 50% Rat Human -DTXSID2024454 Css NA 0.3429 mg/L PBTK NA 95% Rat Human -DTXSID2024458 Clint NA 18.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024458 Fup NA 0.05 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024458 Vd NA 2.4 L/kg 1compartment NA NA Human Human -DTXSID2024458 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2024458 TK.Half.Life NA 18.14 hours 1compartment NA NA Human Human -DTXSID2024458 Css NA 1.01 mg/L 3compartmentss NA 50% Human Human -DTXSID2024458 Css NA 6.829 mg/L 3compartmentss NA 95% Human Human -DTXSID2024458 Css NA 0.6801 mg/L PBTK NA 50% Human Human -DTXSID2024458 Css NA 4.365 mg/L PBTK NA 95% Human Human -DTXSID2024458 Clint NA 18.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024458 Fup NA 0.05 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024458 Vd NA 1.799 L/kg 1compartment NA NA Rat Human -DTXSID2024458 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024458 TK.Half.Life NA 4.857 hours 1compartment NA NA Rat Human -DTXSID2024458 Css NA 0.5584 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024458 Css NA 3.073 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024458 Css NA 0.3549 mg/L PBTK NA 50% Rat Human -DTXSID2024458 Css NA 1.879 mg/L PBTK NA 95% Rat Human -DTXSID2024616 Clint NA 3.838 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024616 Fup NA 0.059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024616 Vd NA 3.059 L/kg 1compartment NA NA Human Human -DTXSID2024616 Days.Css NA 55 Days PBTK NA NA Human Human -DTXSID2024616 TK.Half.Life NA 259.9 hours 1compartment NA NA Human Human -DTXSID2024616 Css NA 10.63 mg/L 3compartmentss NA 50% Human Human -DTXSID2024616 Css NA 59.37 mg/L 3compartmentss NA 95% Human Human -DTXSID2024616 Css NA 7.341 mg/L PBTK NA 50% Human Human -DTXSID2024616 Css NA 39.82 mg/L PBTK NA 95% Human Human -DTXSID2024616 Clint NA 3.838 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024616 Fup NA 0.059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024616 Vd NA 2.294 L/kg 1compartment NA NA Rat Human -DTXSID2024616 Days.Css NA 29 Days PBTK NA NA Rat Human -DTXSID2024616 TK.Half.Life NA 36.2 hours 1compartment NA NA Rat Human -DTXSID2024616 Css NA 5.783 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024616 Css NA 25.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024616 Css NA 3.832 mg/L PBTK NA 50% Rat Human -DTXSID2024616 Css NA 16.49 mg/L PBTK NA 95% Rat Human -DTXSID2024662 Clint NA 14.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024662 Fup NA 0.3084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024662 Vd NA 0.9734 L/kg 1compartment NA NA Human Human +DTXSID2024454 TK.Half.Life NA 0.3533 hours 1compartment NA NA Rat Human +DTXSID2024454 Css NA 0.00433 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024454 Css NA 0.03899 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024454 Css NA 0.003451 mg/L PBTK NA 50% Rat Human +DTXSID2024454 Css NA 0.02525 mg/L PBTK NA 95% Rat Human +DTXSID2024458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024458 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024458 Vd NA 1.451 L/kg 1compartment NA NA Human Human +DTXSID2024458 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2024458 TK.Half.Life NA 19.96 hours 1compartment NA NA Human Human +DTXSID2024458 Css NA 2.235 mg/L 3compartmentss NA 50% Human Human +DTXSID2024458 Css NA 19.64 mg/L 3compartmentss NA 95% Human Human +DTXSID2024458 Css NA 1.376 mg/L PBTK NA 50% Human Human +DTXSID2024458 Css NA 11.73 mg/L PBTK NA 95% Human Human +DTXSID2024458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024458 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024458 Vd NA 1.071 L/kg 1compartment NA NA Rat Human +DTXSID2024458 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2024458 TK.Half.Life NA 7.801 hours 1compartment NA NA Rat Human +DTXSID2024458 Css NA 0.2904 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024458 Css NA 2.195 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024458 Css NA 0.1748 mg/L PBTK NA 50% Rat Human +DTXSID2024458 Css NA 1.271 mg/L PBTK NA 95% Rat Human +DTXSID2024585 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024585 Fup 0.0256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024585 Vd NA 1.593 L/kg 1compartment NA NA Human Human +DTXSID2024585 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2024585 TK.Half.Life NA 12.46 hours 1compartment NA NA Human Human +DTXSID2024585 Css NA 1.184 mg/L 3compartmentss NA 50% Human Human +DTXSID2024585 Css NA 10.33 mg/L 3compartmentss NA 95% Human Human +DTXSID2024585 Css NA 0.7469 mg/L PBTK NA 50% Human Human +DTXSID2024585 Css NA 6.187 mg/L PBTK NA 95% Human Human +DTXSID2024585 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024585 Fup 0.0256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024585 Vd NA 1.185 L/kg 1compartment NA NA Rat Human +DTXSID2024585 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2024585 TK.Half.Life NA 4.668 hours 1compartment NA NA Rat Human +DTXSID2024585 Css NA 0.1533 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024585 Css NA 1.07 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024585 Css NA 0.0941 mg/L PBTK NA 50% Rat Human +DTXSID2024585 Css NA 0.624 mg/L PBTK NA 95% Rat Human +DTXSID2024662 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024662 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024662 Vd NA 1.351 L/kg 1compartment NA NA Human Human DTXSID2024662 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024662 TK.Half.Life NA 1.448 hours 1compartment NA NA Human Human -DTXSID2024662 Css NA 0.09542 mg/L 3compartmentss NA 50% Human Human -DTXSID2024662 Css NA 0.6652 mg/L 3compartmentss NA 95% Human Human -DTXSID2024662 Css NA 0.07201 mg/L PBTK NA 50% Human Human -DTXSID2024662 Css NA 0.4596 mg/L PBTK NA 95% Human Human -DTXSID2024662 Clint NA 14.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024662 Fup NA 0.3084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024662 Vd NA 0.9435 L/kg 1compartment NA NA Rat Human +DTXSID2024662 TK.Half.Life NA 2.187 hours 1compartment NA NA Human Human +DTXSID2024662 Css NA 0.114 mg/L 3compartmentss NA 50% Human Human +DTXSID2024662 Css NA 0.9483 mg/L 3compartmentss NA 95% Human Human +DTXSID2024662 Css NA 0.09764 mg/L PBTK NA 50% Human Human +DTXSID2024662 Css NA 0.6705 mg/L PBTK NA 95% Human Human +DTXSID2024662 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024662 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024662 Vd NA 1.318 L/kg 1compartment NA NA Rat Human DTXSID2024662 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024662 TK.Half.Life NA 0.7687 hours 1compartment NA NA Rat Human -DTXSID2024662 Css NA 0.05067 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024662 Css NA 0.2751 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024662 Css NA 0.03678 mg/L PBTK NA 50% Rat Human -DTXSID2024662 Css NA 0.1793 mg/L PBTK NA 95% Rat Human -DTXSID2024664 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024664 Fup NA 0.8477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024664 Vd NA 0.6184 L/kg 1compartment NA NA Human Human +DTXSID2024662 TK.Half.Life NA 1.165 hours 1compartment NA NA Rat Human +DTXSID2024662 Css NA 0.01295 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024662 Css NA 0.0862 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024662 Css NA 0.01128 mg/L PBTK NA 50% Rat Human +DTXSID2024662 Css NA 0.05806 mg/L PBTK NA 95% Rat Human +DTXSID2024664 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024664 Fup 0.438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024664 Vd NA 0.4349 L/kg 1compartment NA NA Human Human DTXSID2024664 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024664 TK.Half.Life NA 4.735 hours 1compartment NA NA Human Human -DTXSID2024664 Css NA 1.009 mg/L 3compartmentss NA 50% Human Human -DTXSID2024664 Css NA 5.746 mg/L 3compartmentss NA 95% Human Human -DTXSID2024664 Css NA 0.7938 mg/L PBTK NA 50% Human Human -DTXSID2024664 Css NA 3.651 mg/L PBTK NA 95% Human Human -DTXSID2024664 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024664 Fup NA 0.8477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024664 Vd NA 0.6231 L/kg 1compartment NA NA Rat Human +DTXSID2024664 TK.Half.Life NA 6.436 hours 1compartment NA NA Human Human +DTXSID2024664 Css NA 1.462 mg/L 3compartmentss NA 50% Human Human +DTXSID2024664 Css NA 6.655 mg/L 3compartmentss NA 95% Human Human +DTXSID2024664 Css NA 1.037 mg/L PBTK NA 50% Human Human +DTXSID2024664 Css NA 4.138 mg/L PBTK NA 95% Human Human +DTXSID2024664 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024664 Fup 0.438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024664 Vd NA 0.4357 L/kg 1compartment NA NA Rat Human DTXSID2024664 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024664 TK.Half.Life NA 1.622 hours 1compartment NA NA Rat Human -DTXSID2024664 Css NA 0.26 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024664 Css NA 1.439 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024664 Css NA 0.1968 mg/L PBTK NA 50% Rat Human -DTXSID2024664 Css NA 0.8496 mg/L PBTK NA 95% Rat Human -DTXSID2024666 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024666 Fup NA 0.9666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024666 Vd NA 0.7905 L/kg 1compartment NA NA Human Human +DTXSID2024664 TK.Half.Life NA 2.195 hours 1compartment NA NA Rat Human +DTXSID2024664 Css NA 0.0274 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024664 Css NA 0.1788 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024664 Css NA 0.01874 mg/L PBTK NA 50% Rat Human +DTXSID2024664 Css NA 0.1099 mg/L PBTK NA 95% Rat Human +DTXSID2024666 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024666 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024666 Vd NA 0.647 L/kg 1compartment NA NA Human Human DTXSID2024666 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024666 TK.Half.Life NA 5.295 hours 1compartment NA NA Human Human -DTXSID2024666 Css NA 0.8383 mg/L 3compartmentss NA 50% Human Human -DTXSID2024666 Css NA 2.934 mg/L 3compartmentss NA 95% Human Human -DTXSID2024666 Css NA 0.7039 mg/L PBTK NA 50% Human Human -DTXSID2024666 Css NA 2.094 mg/L PBTK NA 95% Human Human -DTXSID2024666 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024666 Fup NA 0.9666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024666 Vd NA 0.8234 L/kg 1compartment NA NA Rat Human +DTXSID2024666 TK.Half.Life NA 6.054 hours 1compartment NA NA Human Human +DTXSID2024666 Css NA 0.9542 mg/L 3compartmentss NA 50% Human Human +DTXSID2024666 Css NA 6.173 mg/L 3compartmentss NA 95% Human Human +DTXSID2024666 Css NA 0.7593 mg/L PBTK NA 50% Human Human +DTXSID2024666 Css NA 3.902 mg/L PBTK NA 95% Human Human +DTXSID2024666 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024666 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024666 Vd NA 0.673 L/kg 1compartment NA NA Rat Human DTXSID2024666 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024666 TK.Half.Life NA 1.878 hours 1compartment NA NA Rat Human -DTXSID2024666 Css NA 0.2139 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024666 Css NA 0.6658 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024666 Css NA 0.1769 mg/L PBTK NA 50% Rat Human -DTXSID2024666 Css NA 0.4368 mg/L PBTK NA 95% Rat Human -DTXSID2024747 Clint NA 11.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024747 Fup NA 0.1301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024747 Vd NA 0.3972 L/kg 1compartment NA NA Human Human -DTXSID2024747 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024747 TK.Half.Life NA 1.266 hours 1compartment NA NA Human Human -DTXSID2024747 Css NA 0.3888 mg/L 3compartmentss NA 50% Human Human -DTXSID2024747 Css NA 2.9 mg/L 3compartmentss NA 95% Human Human -DTXSID2024747 Css NA 0.2442 mg/L PBTK NA 50% Human Human -DTXSID2024747 Css NA 1.752 mg/L PBTK NA 95% Human Human -DTXSID2024747 Clint NA 11.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024747 Fup NA 0.1301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024747 Vd NA 0.3759 L/kg 1compartment NA NA Rat Human +DTXSID2024666 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human +DTXSID2024666 Css NA 0.01819 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024666 Css NA 0.1485 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024666 Css NA 0.01406 mg/L PBTK NA 50% Rat Human +DTXSID2024666 Css NA 0.09301 mg/L PBTK NA 95% Rat Human +DTXSID2024747 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024747 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024747 Vd NA 0.5212 L/kg 1compartment NA NA Human Human +DTXSID2024747 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2024747 TK.Half.Life NA 11.69 hours 1compartment NA NA Human Human +DTXSID2024747 Css NA 1.386 mg/L 3compartmentss NA 50% Human Human +DTXSID2024747 Css NA 5.97 mg/L 3compartmentss NA 95% Human Human +DTXSID2024747 Css NA 0.9836 mg/L PBTK NA 50% Human Human +DTXSID2024747 Css NA 3.797 mg/L PBTK NA 95% Human Human +DTXSID2024747 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024747 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024747 Vd NA 0.5107 L/kg 1compartment NA NA Rat Human DTXSID2024747 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024747 TK.Half.Life NA 0.7164 hours 1compartment NA NA Rat Human -DTXSID2024747 Css NA 0.2106 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024747 Css NA 1.181 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024747 Css NA 0.1249 mg/L PBTK NA 50% Rat Human -DTXSID2024747 Css NA 0.6672 mg/L PBTK NA 95% Rat Human -DTXSID2024797 Clint NA 0.004978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024797 Fup NA 0.4395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024797 Vd NA 0.457 L/kg 1compartment NA NA Human Human -DTXSID2024797 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024797 TK.Half.Life NA 6.684 hours 1compartment NA NA Human Human -DTXSID2024797 Css NA 1.697 mg/L 3compartmentss NA 50% Human Human -DTXSID2024797 Css NA 7.683 mg/L 3compartmentss NA 95% Human Human -DTXSID2024797 Css NA 1.218 mg/L PBTK NA 50% Human Human -DTXSID2024797 Css NA 4.804 mg/L PBTK NA 95% Human Human -DTXSID2024797 Clint NA 0.004978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024797 Fup NA 0.4395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024797 Vd NA 0.4556 L/kg 1compartment NA NA Rat Human -DTXSID2024797 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024797 TK.Half.Life NA 2.277 hours 1compartment NA NA Rat Human -DTXSID2024797 Css NA 0.4662 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024797 Css NA 1.912 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024797 Css NA 0.3195 mg/L PBTK NA 50% Rat Human -DTXSID2024797 Css NA 1.112 mg/L PBTK NA 95% Rat Human -DTXSID2024824 Clint NA 143.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024824 Fup NA 0.0164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024824 Vd NA 5.847 L/kg 1compartment NA NA Human Human -DTXSID2024824 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2024824 TK.Half.Life NA 29.71 hours 1compartment NA NA Human Human -DTXSID2024824 Css NA 0.4216 mg/L 3compartmentss NA 50% Human Human -DTXSID2024824 Css NA 2.386 mg/L 3compartmentss NA 95% Human Human -DTXSID2024824 Css NA 0.367 mg/L PBTK NA 50% Human Human -DTXSID2024824 Css NA 2 mg/L PBTK NA 95% Human Human -DTXSID2024824 Clint NA 143.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024824 Fup NA 0.0164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024824 Vd NA 4.495 L/kg 1compartment NA NA Rat Human -DTXSID2024824 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2024824 TK.Half.Life NA 4.699 hours 1compartment NA NA Rat Human -DTXSID2024824 Css NA 0.2347 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024824 Css NA 0.9645 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024824 Css NA 0.1982 mg/L PBTK NA 50% Rat Human -DTXSID2024824 Css NA 0.8217 mg/L PBTK NA 95% Rat Human -DTXSID2024878 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024878 Fup NA 0.8751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024878 Vd NA 0.8593 L/kg 1compartment NA NA Human Human +DTXSID2024747 TK.Half.Life NA 3.888 hours 1compartment NA NA Rat Human +DTXSID2024747 Css NA 0.007509 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024747 Css NA 0.03263 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024747 Css NA 0.005032 mg/L PBTK NA 50% Rat Human +DTXSID2024747 Css NA 0.0197 mg/L PBTK NA 95% Rat Human +DTXSID2024878 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024878 Fup 0.766 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024878 Vd NA 0.7823 L/kg 1compartment NA NA Human Human DTXSID2024878 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024878 TK.Half.Life NA 6.394 hours 1compartment NA NA Human Human -DTXSID2024878 Css NA 0.9232 mg/L 3compartmentss NA 50% Human Human -DTXSID2024878 Css NA 5.343 mg/L 3compartmentss NA 95% Human Human -DTXSID2024878 Css NA 0.781 mg/L PBTK NA 50% Human Human -DTXSID2024878 Css NA 3.468 mg/L PBTK NA 95% Human Human -DTXSID2024878 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024878 Fup NA 0.8751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024878 Vd NA 0.8694 L/kg 1compartment NA NA Rat Human +DTXSID2024878 TK.Half.Life NA 6.639 hours 1compartment NA NA Human Human +DTXSID2024878 Css NA 0.9814 mg/L 3compartmentss NA 50% Human Human +DTXSID2024878 Css NA 6.563 mg/L 3compartmentss NA 95% Human Human +DTXSID2024878 Css NA 0.8133 mg/L PBTK NA 50% Human Human +DTXSID2024878 Css NA 4.237 mg/L PBTK NA 95% Human Human +DTXSID2024878 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024878 Fup 0.766 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024878 Vd NA 0.7927 L/kg 1compartment NA NA Rat Human DTXSID2024878 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024878 TK.Half.Life NA 2.194 hours 1compartment NA NA Rat Human -DTXSID2024878 Css NA 0.233 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024878 Css NA 1.388 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024878 Css NA 0.1927 mg/L PBTK NA 50% Rat Human -DTXSID2024878 Css NA 0.841 mg/L PBTK NA 95% Rat Human -DTXSID2024953 Clint NA 10.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024953 Fup NA 0.4659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2024953 Vd NA 3.508 L/kg 1compartment NA NA Human Human +DTXSID2024878 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human +DTXSID2024878 Css NA 0.05786 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024878 Css NA 0.3644 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024878 Css NA 0.04827 mg/L PBTK NA 50% Rat Human +DTXSID2024878 Css NA 0.2253 mg/L PBTK NA 95% Rat Human +DTXSID2024953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024953 Fup 0.436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2024953 Vd NA 3.343 L/kg 1compartment NA NA Human Human DTXSID2024953 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2024953 TK.Half.Life NA 3.445 hours 1compartment NA NA Human Human -DTXSID2024953 Css NA 0.04388 mg/L 3compartmentss NA 50% Human Human -DTXSID2024953 Css NA 0.4143 mg/L 3compartmentss NA 95% Human Human -DTXSID2024953 Css NA 0.05883 mg/L PBTK NA 50% Human Human -DTXSID2024953 Css NA 0.395 mg/L PBTK NA 95% Human Human -DTXSID2024953 Clint NA 10.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024953 Fup NA 0.4659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2024953 Vd NA 3.506 L/kg 1compartment NA NA Rat Human +DTXSID2024953 TK.Half.Life NA 2.436 hours 1compartment NA NA Human Human +DTXSID2024953 Css NA 0.0227 mg/L 3compartmentss NA 50% Human Human +DTXSID2024953 Css NA 0.2447 mg/L 3compartmentss NA 95% Human Human +DTXSID2024953 Css NA 0.0292 mg/L PBTK NA 50% Human Human +DTXSID2024953 Css NA 0.232 mg/L PBTK NA 95% Human Human +DTXSID2024953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024953 Fup 0.436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2024953 Vd NA 3.339 L/kg 1compartment NA NA Rat Human DTXSID2024953 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2024953 TK.Half.Life NA 1.966 hours 1compartment NA NA Rat Human -DTXSID2024953 Css NA 0.02138 mg/L 3compartmentss NA 50% Rat Human -DTXSID2024953 Css NA 0.1742 mg/L 3compartmentss NA 95% Rat Human -DTXSID2024953 Css NA 0.02896 mg/L PBTK NA 50% Rat Human -DTXSID2024953 Css NA 0.1557 mg/L PBTK NA 95% Rat Human -DTXSID2025004 Clint NA 0.2049 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025004 Fup NA 0.0302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025004 Vd NA 0.5341 L/kg 1compartment NA NA Human Human -DTXSID2025004 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID2025004 TK.Half.Life NA 86.81 hours 1compartment NA NA Human Human -DTXSID2025004 Css NA 26.88 mg/L 3compartmentss NA 50% Human Human -DTXSID2025004 Css NA 163.6 mg/L 3compartmentss NA 95% Human Human -DTXSID2025004 Css NA 16.22 mg/L PBTK NA 50% Human Human -DTXSID2025004 Css NA 94.57 mg/L PBTK NA 95% Human Human -DTXSID2025004 Clint NA 0.2049 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025004 Fup NA 0.0302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025004 Vd NA 0.4172 L/kg 1compartment NA NA Rat Human -DTXSID2025004 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2025004 TK.Half.Life NA 26.03 hours 1compartment NA NA Rat Human -DTXSID2025004 Css NA 9.078 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025004 Css NA 47.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025004 Css NA 5.086 mg/L PBTK NA 50% Rat Human -DTXSID2025004 Css NA 25.83 mg/L PBTK NA 95% Rat Human -DTXSID2025006 Clint NA 14.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025006 Fup NA 0.0998 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025006 Vd NA 2.554 L/kg 1compartment NA NA Human Human -DTXSID2025006 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2025006 TK.Half.Life NA 16.91 hours 1compartment NA NA Human Human -DTXSID2025006 Css NA 0.8114 mg/L 3compartmentss NA 50% Human Human -DTXSID2025006 Css NA 5.222 mg/L 3compartmentss NA 95% Human Human -DTXSID2025006 Css NA 0.5578 mg/L PBTK NA 50% Human Human -DTXSID2025006 Css NA 3.466 mg/L PBTK NA 95% Human Human -DTXSID2025006 Clint NA 14.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025006 Fup NA 0.0998 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025006 Vd NA 1.922 L/kg 1compartment NA NA Rat Human +DTXSID2024953 TK.Half.Life NA 1.32 hours 1compartment NA NA Rat Human +DTXSID2024953 Css NA 0.00266 mg/L 3compartmentss NA 50% Rat Human +DTXSID2024953 Css NA 0.02329 mg/L 3compartmentss NA 95% Rat Human +DTXSID2024953 Css NA 0.003634 mg/L PBTK NA 50% Rat Human +DTXSID2024953 Css NA 0.02204 mg/L PBTK NA 95% Rat Human +DTXSID2025004 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025004 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025004 Vd NA 0.9979 L/kg 1compartment NA NA Human Human +DTXSID2025004 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2025004 TK.Half.Life NA 2.568 hours 1compartment NA NA Human Human +DTXSID2025004 Css NA 0.2754 mg/L 3compartmentss NA 50% Human Human +DTXSID2025004 Css NA 2.145 mg/L 3compartmentss NA 95% Human Human +DTXSID2025004 Css NA 0.1773 mg/L PBTK NA 50% Human Human +DTXSID2025004 Css NA 1.31 mg/L PBTK NA 95% Human Human +DTXSID2025004 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025004 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025004 Vd NA 0.776 L/kg 1compartment NA NA Rat Human +DTXSID2025004 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2025004 TK.Half.Life NA 1.102 hours 1compartment NA NA Rat Human +DTXSID2025004 Css NA 0.03535 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025004 Css NA 0.2165 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025004 Css NA 0.02222 mg/L PBTK NA 50% Rat Human +DTXSID2025004 Css NA 0.1297 mg/L PBTK NA 95% Rat Human +DTXSID2025006 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025006 Fup 0.0767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025006 Vd NA 2.414 L/kg 1compartment NA NA Human Human +DTXSID2025006 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2025006 TK.Half.Life NA 12.1 hours 1compartment NA NA Human Human +DTXSID2025006 Css NA 0.5144 mg/L 3compartmentss NA 50% Human Human +DTXSID2025006 Css NA 3.371 mg/L 3compartmentss NA 95% Human Human +DTXSID2025006 Css NA 0.3479 mg/L PBTK NA 50% Human Human +DTXSID2025006 Css NA 2.237 mg/L PBTK NA 95% Human Human +DTXSID2025006 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025006 Fup 0.0767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025006 Vd NA 1.814 L/kg 1compartment NA NA Rat Human DTXSID2025006 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025006 TK.Half.Life NA 4.166 hours 1compartment NA NA Rat Human -DTXSID2025006 Css NA 0.4467 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025006 Css NA 2.131 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025006 Css NA 0.2942 mg/L PBTK NA 50% Rat Human -DTXSID2025006 Css NA 1.339 mg/L PBTK NA 95% Rat Human +DTXSID2025006 TK.Half.Life NA 3.277 hours 1compartment NA NA Rat Human +DTXSID2025006 Css NA 0.01923 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025006 Css NA 0.1446 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025006 Css NA 0.01257 mg/L PBTK NA 50% Rat Human +DTXSID2025006 Css NA 0.09092 mg/L PBTK NA 95% Rat Human DTXSID2025050 Clint 2.003 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID2025050 Fup 0.9678 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID2025050 Vd NA 1.616 L/kg 1compartment NA NA Human Human +DTXSID2025050 Vd NA 1.435 L/kg 1compartment NA NA Human Human DTXSID2025050 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025050 TK.Half.Life NA 2.958 hours 1compartment NA NA Human Human -DTXSID2025050 Css NA 0.1576 mg/L 3compartmentss NA 50% Human Human -DTXSID2025050 Css NA 0.6218 mg/L 3compartmentss NA 95% Human Human -DTXSID2025050 Css NA 0.1558 mg/L PBTK NA 50% Human Human -DTXSID2025050 Css NA 0.5606 mg/L PBTK NA 95% Human Human +DTXSID2025050 TK.Half.Life NA 2.633 hours 1compartment NA NA Human Human +DTXSID2025050 Css NA 0.1345 mg/L 3compartmentss NA 50% Human Human +DTXSID2025050 Css NA 0.5275 mg/L 3compartmentss NA 95% Human Human +DTXSID2025050 Css NA 0.1291 mg/L PBTK NA 50% Human Human +DTXSID2025050 Css NA 0.4552 mg/L PBTK NA 95% Human Human DTXSID2025050 Clint 2.003 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID2025050 Fup 0.9678 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID2025050 Vd NA 1.634 L/kg 1compartment NA NA Rat Human +DTXSID2025050 Vd NA 1.459 L/kg 1compartment NA NA Rat Human DTXSID2025050 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025050 TK.Half.Life NA 1.557 hours 1compartment NA NA Rat Human -DTXSID2025050 Css NA 0.0662 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025050 Css NA 0.1956 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025050 Css NA 0.06599 mg/L PBTK NA 50% Rat Human -DTXSID2025050 Css NA 0.1594 mg/L PBTK NA 95% Rat Human -DTXSID2025058 Clint NA 18.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025058 Fup NA 0.4567 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025058 Vd NA 2.255 L/kg 1compartment NA NA Human Human +DTXSID2025050 TK.Half.Life NA 1.39 hours 1compartment NA NA Rat Human +DTXSID2025050 Css NA 0.003781 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025050 Css NA 0.01966 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025050 Css NA 0.003634 mg/L PBTK NA 50% Rat Human +DTXSID2025050 Css NA 0.0175 mg/L PBTK NA 95% Rat Human +DTXSID2025058 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025058 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025058 Vd NA 2.05 L/kg 1compartment NA NA Human Human DTXSID2025058 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025058 TK.Half.Life NA 2.223 hours 1compartment NA NA Human Human -DTXSID2025058 Css NA 0.04386 mg/L 3compartmentss NA 50% Human Human -DTXSID2025058 Css NA 0.3819 mg/L 3compartmentss NA 95% Human Human -DTXSID2025058 Css NA 0.04222 mg/L PBTK NA 50% Human Human -DTXSID2025058 Css NA 0.3026 mg/L PBTK NA 95% Human Human -DTXSID2025058 Clint NA 18.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025058 Fup NA 0.4567 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025058 Vd NA 2.174 L/kg 1compartment NA NA Rat Human +DTXSID2025058 TK.Half.Life NA 1.934 hours 1compartment NA NA Human Human +DTXSID2025058 Css NA 0.03608 mg/L 3compartmentss NA 50% Human Human +DTXSID2025058 Css NA 0.3297 mg/L 3compartmentss NA 95% Human Human +DTXSID2025058 Css NA 0.03384 mg/L PBTK NA 50% Human Human +DTXSID2025058 Css NA 0.257 mg/L PBTK NA 95% Human Human +DTXSID2025058 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025058 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025058 Vd NA 1.995 L/kg 1compartment NA NA Rat Human DTXSID2025058 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025058 TK.Half.Life NA 1.101 hours 1compartment NA NA Rat Human -DTXSID2025058 Css NA 0.02274 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025058 Css NA 0.1591 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025058 Css NA 0.02157 mg/L PBTK NA 50% Rat Human -DTXSID2025058 Css NA 0.1186 mg/L PBTK NA 95% Rat Human +DTXSID2025058 TK.Half.Life NA 0.967 hours 1compartment NA NA Rat Human +DTXSID2025058 Css NA 0.004438 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025058 Css NA 0.03235 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025058 Css NA 0.004248 mg/L PBTK NA 50% Rat Human +DTXSID2025058 Css NA 0.02442 mg/L PBTK NA 95% Rat Human DTXSID2025133 Clint 454 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2025133 Fup NA 0.2656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025133 Vd NA 2.435 L/kg 1compartment NA NA Human Human +DTXSID2025133 Fup 0.0689 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025133 Vd NA 1.512 L/kg 1compartment NA NA Human Human DTXSID2025133 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025133 TK.Half.Life NA 1.98 hours 1compartment NA NA Human Human -DTXSID2025133 Css NA 0.00821 mg/L 3compartmentss NA 50% Human Human -DTXSID2025133 Css NA 0.06468 mg/L 3compartmentss NA 95% Human Human -DTXSID2025133 Css NA 0.00611 mg/L PBTK NA 50% Human Human -DTXSID2025133 Css NA 0.04615 mg/L PBTK NA 95% Human Human +DTXSID2025133 TK.Half.Life NA 1.512 hours 1compartment NA NA Human Human +DTXSID2025133 Css NA 0.01876 mg/L 3compartmentss NA 50% Human Human +DTXSID2025133 Css NA 0.1865 mg/L 3compartmentss NA 95% Human Human +DTXSID2025133 Css NA 0.01222 mg/L PBTK NA 50% Human Human +DTXSID2025133 Css NA 0.1188 mg/L PBTK NA 95% Human Human DTXSID2025133 Clint 454 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2025133 Fup NA 0.2656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025133 Vd NA 1.871 L/kg 1compartment NA NA Rat Human +DTXSID2025133 Fup 0.0689 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025133 Vd NA 1.145 L/kg 1compartment NA NA Rat Human DTXSID2025133 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025133 TK.Half.Life NA 0.6478 hours 1compartment NA NA Rat Human -DTXSID2025133 Css NA 0.004587 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025133 Css NA 0.02977 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025133 Css NA 0.003286 mg/L PBTK NA 50% Rat Human -DTXSID2025133 Css NA 0.02036 mg/L PBTK NA 95% Rat Human -DTXSID2025135 Clint NA 5.406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025135 Fup NA 0.2586 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025135 Vd NA 2.348 L/kg 1compartment NA NA Human Human +DTXSID2025133 TK.Half.Life NA 0.5169 hours 1compartment NA NA Rat Human +DTXSID2025133 Css NA 0.002604 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025133 Css NA 0.02017 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025133 Css NA 0.001678 mg/L PBTK NA 50% Rat Human +DTXSID2025133 Css NA 0.01255 mg/L PBTK NA 95% Rat Human +DTXSID2025135 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025135 Fup 0.0551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025135 Vd NA 1.289 L/kg 1compartment NA NA Human Human DTXSID2025135 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025135 TK.Half.Life NA 12.96 hours 1compartment NA NA Human Human -DTXSID2025135 Css NA 0.5761 mg/L 3compartmentss NA 50% Human Human -DTXSID2025135 Css NA 2.999 mg/L 3compartmentss NA 95% Human Human -DTXSID2025135 Css NA 0.4288 mg/L PBTK NA 50% Human Human -DTXSID2025135 Css NA 2.101 mg/L PBTK NA 95% Human Human -DTXSID2025135 Clint NA 5.406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025135 Fup NA 0.2586 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025135 Vd NA 1.806 L/kg 1compartment NA NA Rat Human +DTXSID2025135 TK.Half.Life NA 5.411 hours 1compartment NA NA Human Human +DTXSID2025135 Css NA 0.5539 mg/L 3compartmentss NA 50% Human Human +DTXSID2025135 Css NA 4.114 mg/L 3compartmentss NA 95% Human Human +DTXSID2025135 Css NA 0.3521 mg/L PBTK NA 50% Human Human +DTXSID2025135 Css NA 2.513 mg/L PBTK NA 95% Human Human +DTXSID2025135 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025135 Fup 0.0551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025135 Vd NA 0.9758 L/kg 1compartment NA NA Rat Human DTXSID2025135 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025135 TK.Half.Life NA 3.631 hours 1compartment NA NA Rat Human -DTXSID2025135 Css NA 0.2934 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025135 Css NA 1.112 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025135 Css NA 0.2095 mg/L PBTK NA 50% Rat Human -DTXSID2025135 Css NA 0.7363 mg/L PBTK NA 95% Rat Human -DTXSID2025137 Clint NA 6.477 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025137 Fup NA 0.2778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025137 Vd NA 2.406 L/kg 1compartment NA NA Human Human +DTXSID2025135 TK.Half.Life NA 2.211 hours 1compartment NA NA Rat Human +DTXSID2025135 Css NA 0.07196 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025135 Css NA 0.446 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025135 Css NA 0.0445 mg/L PBTK NA 50% Rat Human +DTXSID2025135 Css NA 0.2642 mg/L PBTK NA 95% Rat Human +DTXSID2025137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025137 Fup 0.0594 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025137 Vd NA 1.349 L/kg 1compartment NA NA Human Human DTXSID2025137 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025137 TK.Half.Life NA 11.32 hours 1compartment NA NA Human Human -DTXSID2025137 Css NA 0.4798 mg/L 3compartmentss NA 50% Human Human -DTXSID2025137 Css NA 2.57 mg/L 3compartmentss NA 95% Human Human -DTXSID2025137 Css NA 0.3576 mg/L PBTK NA 50% Human Human -DTXSID2025137 Css NA 1.8 mg/L PBTK NA 95% Human Human -DTXSID2025137 Clint NA 6.477 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025137 Fup NA 0.2778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025137 Vd NA 1.852 L/kg 1compartment NA NA Rat Human +DTXSID2025137 TK.Half.Life NA 5.419 hours 1compartment NA NA Human Human +DTXSID2025137 Css NA 0.5176 mg/L 3compartmentss NA 50% Human Human +DTXSID2025137 Css NA 3.917 mg/L 3compartmentss NA 95% Human Human +DTXSID2025137 Css NA 0.3302 mg/L PBTK NA 50% Human Human +DTXSID2025137 Css NA 2.439 mg/L PBTK NA 95% Human Human +DTXSID2025137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025137 Fup 0.0594 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025137 Vd NA 1.021 L/kg 1compartment NA NA Rat Human DTXSID2025137 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025137 TK.Half.Life NA 3.132 hours 1compartment NA NA Rat Human -DTXSID2025137 Css NA 0.2457 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025137 Css NA 0.9484 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025137 Css NA 0.1777 mg/L PBTK NA 50% Rat Human -DTXSID2025137 Css NA 0.6403 mg/L PBTK NA 95% Rat Human -DTXSID2025139 Clint NA 193.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025139 Fup NA 0.1477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025139 Vd NA 3.221 L/kg 1compartment NA NA Human Human -DTXSID2025139 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025139 TK.Half.Life NA 3.945 hours 1compartment NA NA Human Human -DTXSID2025139 Css NA 0.05152 mg/L 3compartmentss NA 50% Human Human -DTXSID2025139 Css NA 0.3375 mg/L 3compartmentss NA 95% Human Human -DTXSID2025139 Css NA 0.03668 mg/L PBTK NA 50% Human Human -DTXSID2025139 Css NA 0.2298 mg/L PBTK NA 95% Human Human -DTXSID2025139 Clint NA 193.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025139 Fup NA 0.1477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025139 Vd NA 2.447 L/kg 1compartment NA NA Rat Human -DTXSID2025139 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025139 TK.Half.Life NA 1.035 hours 1compartment NA NA Rat Human -DTXSID2025139 Css NA 0.02902 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025139 Css NA 0.1622 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025139 Css NA 0.01983 mg/L PBTK NA 50% Rat Human -DTXSID2025139 Css NA 0.1047 mg/L PBTK NA 95% Rat Human -DTXSID2025183 Clint NA 16.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025183 Fup NA 0.0721 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025183 Vd NA 1.67 L/kg 1compartment NA NA Human Human +DTXSID2025137 TK.Half.Life NA 2.177 hours 1compartment NA NA Rat Human +DTXSID2025137 Css NA 0.06717 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025137 Css NA 0.3992 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025137 Css NA 0.04186 mg/L PBTK NA 50% Rat Human +DTXSID2025137 Css NA 0.2377 mg/L PBTK NA 95% Rat Human +DTXSID2025183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025183 Fup 0.0295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025183 Vd NA 1.11 L/kg 1compartment NA NA Human Human DTXSID2025183 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025183 TK.Half.Life NA 7.753 hours 1compartment NA NA Human Human -DTXSID2025183 Css NA 0.6098 mg/L 3compartmentss NA 50% Human Human -DTXSID2025183 Css NA 4.386 mg/L 3compartmentss NA 95% Human Human -DTXSID2025183 Css NA 0.3999 mg/L PBTK NA 50% Human Human -DTXSID2025183 Css NA 2.748 mg/L PBTK NA 95% Human Human -DTXSID2025183 Clint NA 16.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025183 Fup NA 0.0721 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025183 Vd NA 1.262 L/kg 1compartment NA NA Rat Human +DTXSID2025183 TK.Half.Life NA 7.307 hours 1compartment NA NA Human Human +DTXSID2025183 Css NA 1.002 mg/L 3compartmentss NA 50% Human Human +DTXSID2025183 Css NA 9.199 mg/L 3compartmentss NA 95% Human Human +DTXSID2025183 Css NA 0.6218 mg/L PBTK NA 50% Human Human +DTXSID2025183 Css NA 5.505 mg/L PBTK NA 95% Human Human +DTXSID2025183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025183 Fup 0.0295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025183 Vd NA 0.8317 L/kg 1compartment NA NA Rat Human DTXSID2025183 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025183 TK.Half.Life NA 2.855 hours 1compartment NA NA Rat Human -DTXSID2025183 Css NA 0.3375 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025183 Css NA 1.799 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025183 Css NA 0.2088 mg/L PBTK NA 50% Rat Human -DTXSID2025183 Css NA 1.052 mg/L PBTK NA 95% Rat Human -DTXSID2025210 Clint NA 6.432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025210 Fup NA 0.0236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025210 Vd NA 0.3934 L/kg 1compartment NA NA Human Human +DTXSID2025183 TK.Half.Life NA 3.125 hours 1compartment NA NA Rat Human +DTXSID2025183 Css NA 0.1312 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025183 Css NA 0.9465 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025183 Css NA 0.07856 mg/L PBTK NA 50% Rat Human +DTXSID2025183 Css NA 0.5464 mg/L PBTK NA 95% Rat Human +DTXSID2025210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025210 Fup 0.061 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025210 Vd NA 0.2348 L/kg 1compartment NA NA Human Human DTXSID2025210 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025210 TK.Half.Life NA 9.111 hours 1compartment NA NA Human Human -DTXSID2025210 Css NA 4.135 mg/L 3compartmentss NA 50% Human Human -DTXSID2025210 Css NA 35.18 mg/L 3compartmentss NA 95% Human Human -DTXSID2025210 Css NA 2.479 mg/L PBTK NA 50% Human Human -DTXSID2025210 Css NA 20.38 mg/L PBTK NA 95% Human Human -DTXSID2025210 Clint NA 6.432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025210 Fup NA 0.0236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025210 Vd NA 0.3229 L/kg 1compartment NA NA Rat Human +DTXSID2025210 TK.Half.Life NA 0.8836 hours 1compartment NA NA Human Human +DTXSID2025210 Css NA 0.5384 mg/L 3compartmentss NA 50% Human Human +DTXSID2025210 Css NA 4.04 mg/L 3compartmentss NA 95% Human Human +DTXSID2025210 Css NA 0.3224 mg/L PBTK NA 50% Human Human +DTXSID2025210 Css NA 2.362 mg/L PBTK NA 95% Human Human +DTXSID2025210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025210 Fup 0.061 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025210 Vd NA 0.2281 L/kg 1compartment NA NA Rat Human DTXSID2025210 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025210 TK.Half.Life NA 4.699 hours 1compartment NA NA Rat Human -DTXSID2025210 Css NA 2.246 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025210 Css NA 15.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025210 Css NA 1.252 mg/L PBTK NA 50% Rat Human -DTXSID2025210 Css NA 8.29 mg/L PBTK NA 95% Rat Human -DTXSID2025216 Clint NA 3.947 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025216 Fup NA 0.1915 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025216 Vd NA 2.686 L/kg 1compartment NA NA Human Human -DTXSID2025216 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2025216 TK.Half.Life NA 36.77 hours 1compartment NA NA Human Human -DTXSID2025216 Css NA 1.586 mg/L 3compartmentss NA 50% Human Human -DTXSID2025216 Css NA 7.672 mg/L 3compartmentss NA 95% Human Human -DTXSID2025216 Css NA 1.146 mg/L PBTK NA 50% Human Human -DTXSID2025216 Css NA 5.242 mg/L PBTK NA 95% Human Human -DTXSID2025216 Clint NA 3.947 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025216 Fup NA 0.1915 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025216 Vd NA 2.037 L/kg 1compartment NA NA Rat Human -DTXSID2025216 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2025216 TK.Half.Life NA 7.741 hours 1compartment NA NA Rat Human -DTXSID2025216 Css NA 0.7973 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025216 Css NA 2.647 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025216 Css NA 0.5509 mg/L PBTK NA 50% Rat Human -DTXSID2025216 Css NA 1.762 mg/L PBTK NA 95% Rat Human -DTXSID2025264 Clint NA 522.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025264 Fup NA 0.0788 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025264 Vd NA 0.8679 L/kg 1compartment NA NA Human Human +DTXSID2025210 TK.Half.Life NA 0.5307 hours 1compartment NA NA Rat Human +DTXSID2025210 Css NA 0.06959 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025210 Css NA 0.4317 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025210 Css NA 0.04028 mg/L PBTK NA 50% Rat Human +DTXSID2025210 Css NA 0.2453 mg/L PBTK NA 95% Rat Human +DTXSID2025264 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025264 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025264 Vd NA 1.798 L/kg 1compartment NA NA Human Human DTXSID2025264 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025264 TK.Half.Life NA 0.8473 hours 1compartment NA NA Human Human -DTXSID2025264 Css NA 0.01622 mg/L 3compartmentss NA 50% Human Human -DTXSID2025264 Css NA 0.1375 mg/L 3compartmentss NA 95% Human Human -DTXSID2025264 Css NA 0.01027 mg/L PBTK NA 50% Human Human -DTXSID2025264 Css NA 0.08401 mg/L PBTK NA 95% Human Human -DTXSID2025264 Clint NA 522.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025264 Fup NA 0.0788 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025264 Vd NA 0.6837 L/kg 1compartment NA NA Rat Human +DTXSID2025264 TK.Half.Life NA 2.758 hours 1compartment NA NA Human Human +DTXSID2025264 Css NA 0.09224 mg/L 3compartmentss NA 50% Human Human +DTXSID2025264 Css NA 0.6844 mg/L 3compartmentss NA 95% Human Human +DTXSID2025264 Css NA 0.06964 mg/L PBTK NA 50% Human Human +DTXSID2025264 Css NA 0.4785 mg/L PBTK NA 95% Human Human +DTXSID2025264 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025264 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025264 Vd NA 1.42 L/kg 1compartment NA NA Rat Human DTXSID2025264 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025264 TK.Half.Life NA 0.3049 hours 1compartment NA NA Rat Human -DTXSID2025264 Css NA 0.009316 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025264 Css NA 0.06536 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025264 Css NA 0.00554 mg/L PBTK NA 50% Rat Human -DTXSID2025264 Css NA 0.03714 mg/L PBTK NA 95% Rat Human -DTXSID2025345 Clint NA 3.947 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025345 Fup NA 0.7468 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025345 Vd NA 1.349 L/kg 1compartment NA NA Human Human +DTXSID2025264 TK.Half.Life NA 1.015 hours 1compartment NA NA Rat Human +DTXSID2025264 Css NA 0.01173 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025264 Css NA 0.06248 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025264 Css NA 0.008862 mg/L PBTK NA 50% Rat Human +DTXSID2025264 Css NA 0.04388 mg/L PBTK NA 95% Rat Human +DTXSID2025345 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025345 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025345 Vd NA 0.8904 L/kg 1compartment NA NA Human Human DTXSID2025345 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025345 TK.Half.Life NA 2.264 hours 1compartment NA NA Human Human -DTXSID2025345 Css NA 0.1404 mg/L 3compartmentss NA 50% Human Human -DTXSID2025345 Css NA 1.091 mg/L 3compartmentss NA 95% Human Human -DTXSID2025345 Css NA 0.1234 mg/L PBTK NA 50% Human Human -DTXSID2025345 Css NA 0.7546 mg/L PBTK NA 95% Human Human -DTXSID2025345 Clint NA 3.947 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025345 Fup NA 0.7468 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025345 Vd NA 1.212 L/kg 1compartment NA NA Rat Human +DTXSID2025345 TK.Half.Life NA 1.048 hours 1compartment NA NA Human Human +DTXSID2025345 Css NA 0.05482 mg/L 3compartmentss NA 50% Human Human +DTXSID2025345 Css NA 0.4234 mg/L 3compartmentss NA 95% Human Human +DTXSID2025345 Css NA 0.04131 mg/L PBTK NA 50% Human Human +DTXSID2025345 Css NA 0.2881 mg/L PBTK NA 95% Human Human +DTXSID2025345 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025345 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025345 Vd NA 0.7945 L/kg 1compartment NA NA Rat Human DTXSID2025345 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025345 TK.Half.Life NA 1.037 hours 1compartment NA NA Rat Human -DTXSID2025345 Css NA 0.06356 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025345 Css NA 0.4682 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025345 Css NA 0.0554 mg/L PBTK NA 50% Rat Human -DTXSID2025345 Css NA 0.3018 mg/L PBTK NA 95% Rat Human -DTXSID2025347 Clint NA 3.879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025347 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025347 Vd NA 1.024 L/kg 1compartment NA NA Human Human +DTXSID2025345 TK.Half.Life NA 0.4814 hours 1compartment NA NA Rat Human +DTXSID2025345 Css NA 0.006766 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025345 Css NA 0.03948 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025345 Css NA 0.005109 mg/L PBTK NA 50% Rat Human +DTXSID2025345 Css NA 0.02681 mg/L PBTK NA 95% Rat Human +DTXSID2025347 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025347 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025347 Vd NA 0.747 L/kg 1compartment NA NA Human Human DTXSID2025347 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025347 TK.Half.Life NA 1.308 hours 1compartment NA NA Human Human -DTXSID2025347 Css NA 0.1093 mg/L 3compartmentss NA 50% Human Human -DTXSID2025347 Css NA 0.9632 mg/L 3compartmentss NA 95% Human Human -DTXSID2025347 Css NA 0.09624 mg/L PBTK NA 50% Human Human -DTXSID2025347 Css NA 0.7028 mg/L PBTK NA 95% Human Human -DTXSID2025347 Clint NA 3.879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025347 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025347 Vd NA 1.022 L/kg 1compartment NA NA Rat Human +DTXSID2025347 TK.Half.Life NA 8.176 hours 1compartment NA NA Human Human +DTXSID2025347 Css NA 1.038 mg/L 3compartmentss NA 50% Human Human +DTXSID2025347 Css NA 7.439 mg/L 3compartmentss NA 95% Human Human +DTXSID2025347 Css NA 0.8365 mg/L PBTK NA 50% Human Human +DTXSID2025347 Css NA 4.696 mg/L PBTK NA 95% Human Human +DTXSID2025347 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025347 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025347 Vd NA 0.7432 L/kg 1compartment NA NA Rat Human DTXSID2025347 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025347 TK.Half.Life NA 0.6822 hours 1compartment NA NA Rat Human -DTXSID2025347 Css NA 0.04952 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025347 Css NA 0.3577 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025347 Css NA 0.04346 mg/L PBTK NA 50% Rat Human -DTXSID2025347 Css NA 0.2286 mg/L PBTK NA 95% Rat Human -DTXSID2025391 Clint NA 28.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025391 Fup NA 0.9097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025391 Vd NA 1.887 L/kg 1compartment NA NA Human Human +DTXSID2025347 TK.Half.Life NA 2.755 hours 1compartment NA NA Rat Human +DTXSID2025347 Css NA 0.01995 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025347 Css NA 0.1765 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025347 Css NA 0.01552 mg/L PBTK NA 50% Rat Human +DTXSID2025347 Css NA 0.1105 mg/L PBTK NA 95% Rat Human +DTXSID2025391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025391 Fup 0.435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025391 Vd NA 1.288 L/kg 1compartment NA NA Human Human DTXSID2025391 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025391 TK.Half.Life NA 1.299 hours 1compartment NA NA Human Human -DTXSID2025391 Css NA 0.01988 mg/L 3compartmentss NA 50% Human Human -DTXSID2025391 Css NA 0.206 mg/L 3compartmentss NA 95% Human Human -DTXSID2025391 Css NA 0.0186 mg/L PBTK NA 50% Human Human -DTXSID2025391 Css NA 0.1585 mg/L PBTK NA 95% Human Human -DTXSID2025391 Clint NA 28.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025391 Fup NA 0.9097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025391 Vd NA 1.629 L/kg 1compartment NA NA Rat Human +DTXSID2025391 TK.Half.Life NA 1.384 hours 1compartment NA NA Human Human +DTXSID2025391 Css NA 0.03764 mg/L 3compartmentss NA 50% Human Human +DTXSID2025391 Css NA 0.3338 mg/L 3compartmentss NA 95% Human Human +DTXSID2025391 Css NA 0.03019 mg/L PBTK NA 50% Human Human +DTXSID2025391 Css NA 0.2377 mg/L PBTK NA 95% Human Human +DTXSID2025391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025391 Fup 0.435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025391 Vd NA 1.101 L/kg 1compartment NA NA Rat Human DTXSID2025391 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025391 TK.Half.Life NA 0.5059 hours 1compartment NA NA Rat Human -DTXSID2025391 Css NA 0.009916 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025391 Css NA 0.08812 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025391 Css NA 0.009442 mg/L PBTK NA 50% Rat Human -DTXSID2025391 Css NA 0.06743 mg/L PBTK NA 95% Rat Human -DTXSID2025422 Clint NA 0.4202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025422 Fup NA 0.7362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025422 Vd NA 1.021 L/kg 1compartment NA NA Human Human +DTXSID2025391 TK.Half.Life NA 0.5854 hours 1compartment NA NA Rat Human +DTXSID2025391 Css NA 0.001298 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025391 Css NA 0.01328 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025391 Css NA 0.001025 mg/L PBTK NA 50% Rat Human +DTXSID2025391 Css NA 0.009057 mg/L PBTK NA 95% Rat Human +DTXSID2025422 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025422 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025422 Vd NA 0.7815 L/kg 1compartment NA NA Human Human DTXSID2025422 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025422 TK.Half.Life NA 5.536 hours 1compartment NA NA Human Human -DTXSID2025422 Css NA 0.5804 mg/L 3compartmentss NA 50% Human Human -DTXSID2025422 Css NA 3.828 mg/L 3compartmentss NA 95% Human Human -DTXSID2025422 Css NA 0.5041 mg/L PBTK NA 50% Human Human -DTXSID2025422 Css NA 2.48 mg/L PBTK NA 95% Human Human -DTXSID2025422 Clint NA 0.4202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025422 Fup NA 0.7362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025422 Vd NA 0.9779 L/kg 1compartment NA NA Rat Human +DTXSID2025422 TK.Half.Life NA 0.9715 hours 1compartment NA NA Human Human +DTXSID2025422 Css NA 0.06092 mg/L 3compartmentss NA 50% Human Human +DTXSID2025422 Css NA 0.4629 mg/L 3compartmentss NA 95% Human Human +DTXSID2025422 Css NA 0.04466 mg/L PBTK NA 50% Human Human +DTXSID2025422 Css NA 0.3092 mg/L PBTK NA 95% Human Human +DTXSID2025422 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025422 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025422 Vd NA 0.7109 L/kg 1compartment NA NA Rat Human DTXSID2025422 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025422 TK.Half.Life NA 2.217 hours 1compartment NA NA Rat Human -DTXSID2025422 Css NA 0.1935 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025422 Css NA 1.278 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025422 Css NA 0.1629 mg/L PBTK NA 50% Rat Human -DTXSID2025422 Css NA 0.7724 mg/L PBTK NA 95% Rat Human -DTXSID2025474 Clint NA 80.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025474 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025474 Vd NA 109.1 L/kg 1compartment NA NA Human Human -DTXSID2025474 Days.Css NA 207 Days PBTK NA NA Human Human -DTXSID2025474 TK.Half.Life NA 876.6 hours 1compartment NA NA Human Human -DTXSID2025474 Css NA 0.04978 mg/L 3compartmentss NA 50% Human Human -DTXSID2025474 Css NA 0.3033 mg/L 3compartmentss NA 95% Human Human -DTXSID2025474 Css NA 0.6656 mg/L PBTK NA 50% Human Human -DTXSID2025474 Css NA 3.75 mg/L PBTK NA 95% Human Human -DTXSID2025474 Clint NA 80.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025474 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025474 Vd NA 94.59 L/kg 1compartment NA NA Rat Human -DTXSID2025474 Days.Css NA 135 Days PBTK NA NA Rat Human -DTXSID2025474 TK.Half.Life NA 133.5 hours 1compartment NA NA Rat Human -DTXSID2025474 Css NA 0.02536 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025474 Css NA 0.1116 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025474 Css NA 0.3575 mg/L PBTK NA 50% Rat Human -DTXSID2025474 Css NA 1.526 mg/L PBTK NA 95% Rat Human -DTXSID2025501 Clint NA 2.069 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025501 Fup NA 0.1512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025501 Vd NA 2.585 L/kg 1compartment NA NA Human Human -DTXSID2025501 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID2025501 TK.Half.Life NA 65.39 hours 1compartment NA NA Human Human -DTXSID2025501 Css NA 3.184 mg/L 3compartmentss NA 50% Human Human -DTXSID2025501 Css NA 13.91 mg/L 3compartmentss NA 95% Human Human -DTXSID2025501 Css NA 2.255 mg/L PBTK NA 50% Human Human -DTXSID2025501 Css NA 9.251 mg/L PBTK NA 95% Human Human -DTXSID2025501 Clint NA 2.069 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025501 Fup NA 0.1512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025501 Vd NA 1.957 L/kg 1compartment NA NA Rat Human -DTXSID2025501 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2025501 TK.Half.Life NA 13.64 hours 1compartment NA NA Rat Human -DTXSID2025501 Css NA 1.513 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025501 Css NA 4.692 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025501 Css NA 1.024 mg/L PBTK NA 50% Rat Human -DTXSID2025501 Css NA 2.913 mg/L PBTK NA 95% Rat Human -DTXSID2025503 Clint NA 41.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025503 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025503 Vd NA 2.453 L/kg 1compartment NA NA Human Human -DTXSID2025503 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2025503 TK.Half.Life NA 14.1 hours 1compartment NA NA Human Human -DTXSID2025503 Css NA 0.7497 mg/L 3compartmentss NA 50% Human Human -DTXSID2025503 Css NA 5.655 mg/L 3compartmentss NA 95% Human Human -DTXSID2025503 Css NA 0.4948 mg/L PBTK NA 50% Human Human -DTXSID2025503 Css NA 3.613 mg/L PBTK NA 95% Human Human -DTXSID2025503 Clint NA 41.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025503 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025503 Vd NA 1.832 L/kg 1compartment NA NA Rat Human -DTXSID2025503 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025503 TK.Half.Life NA 3.709 hours 1compartment NA NA Rat Human -DTXSID2025503 Css NA 0.4255 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025503 Css NA 2.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025503 Css NA 0.266 mg/L PBTK NA 50% Rat Human -DTXSID2025503 Css NA 1.572 mg/L PBTK NA 95% Rat Human -DTXSID2025505 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025505 Fup NA 0.0088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025505 Vd NA 7.421 L/kg 1compartment NA NA Human Human -DTXSID2025505 Days.Css NA 2153 Days PBTK NA NA Human Human -DTXSID2025505 TK.Half.Life NA 7907 hours 1compartment NA NA Human Human -DTXSID2025505 Css NA 108.5 mg/L 3compartmentss NA 50% Human Human -DTXSID2025505 Css NA 731.5 mg/L 3compartmentss NA 95% Human Human -DTXSID2025505 Css NA 104.1 mg/L PBTK NA 50% Human Human -DTXSID2025505 Css NA 502.2 mg/L PBTK NA 95% Human Human -DTXSID2025505 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025505 Fup NA 0.0088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025505 Vd NA 5.773 L/kg 1compartment NA NA Rat Human -DTXSID2025505 Days.Css NA 569 Days PBTK NA NA Rat Human -DTXSID2025505 TK.Half.Life NA 1601 hours 1compartment NA NA Rat Human -DTXSID2025505 Css NA 29.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025505 Css NA 178.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025505 Css NA 27.21 mg/L PBTK NA 50% Rat Human -DTXSID2025505 Css NA 113.4 mg/L PBTK NA 95% Rat Human -DTXSID2025632 Clint NA 8.039 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025632 Fup NA 0.4159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025632 Vd NA 1.089 L/kg 1compartment NA NA Human Human +DTXSID2025422 TK.Half.Life NA 0.4615 hours 1compartment NA NA Rat Human +DTXSID2025422 Css NA 0.007648 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025422 Css NA 0.04406 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025422 Css NA 0.005637 mg/L PBTK NA 50% Rat Human +DTXSID2025422 Css NA 0.02921 mg/L PBTK NA 95% Rat Human +DTXSID2025501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025501 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025501 Vd NA 2.349 L/kg 1compartment NA NA Human Human +DTXSID2025501 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2025501 TK.Half.Life NA 7.68 hours 1compartment NA NA Human Human +DTXSID2025501 Css NA 0.3352 mg/L 3compartmentss NA 50% Human Human +DTXSID2025501 Css NA 2.358 mg/L 3compartmentss NA 95% Human Human +DTXSID2025501 Css NA 0.2324 mg/L PBTK NA 50% Human Human +DTXSID2025501 Css NA 1.551 mg/L PBTK NA 95% Human Human +DTXSID2025501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025501 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025501 Vd NA 1.78 L/kg 1compartment NA NA Rat Human +DTXSID2025501 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2025501 TK.Half.Life NA 2.225 hours 1compartment NA NA Rat Human +DTXSID2025501 Css NA 0.04237 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025501 Css NA 0.2327 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025501 Css NA 0.02914 mg/L PBTK NA 50% Rat Human +DTXSID2025501 Css NA 0.1521 mg/L PBTK NA 95% Rat Human +DTXSID2025503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025503 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025503 Vd NA 2.439 L/kg 1compartment NA NA Human Human +DTXSID2025503 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2025503 TK.Half.Life NA 25.6 hours 1compartment NA NA Human Human +DTXSID2025503 Css NA 1.449 mg/L 3compartmentss NA 50% Human Human +DTXSID2025503 Css NA 10.9 mg/L 3compartmentss NA 95% Human Human +DTXSID2025503 Css NA 0.9597 mg/L PBTK NA 50% Human Human +DTXSID2025503 Css NA 6.93 mg/L PBTK NA 95% Human Human +DTXSID2025503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025503 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025503 Vd NA 1.822 L/kg 1compartment NA NA Rat Human +DTXSID2025503 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2025503 TK.Half.Life NA 6.627 hours 1compartment NA NA Rat Human +DTXSID2025503 Css NA 0.1867 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025503 Css NA 1.117 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025503 Css NA 0.1216 mg/L PBTK NA 50% Rat Human +DTXSID2025503 Css NA 0.7136 mg/L PBTK NA 95% Rat Human +DTXSID2025505 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025505 Fup 0.0358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025505 Vd NA 12.63 L/kg 1compartment NA NA Human Human +DTXSID2025505 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID2025505 TK.Half.Life NA 97.86 hours 1compartment NA NA Human Human +DTXSID2025505 Css NA 0.5049 mg/L 3compartmentss NA 50% Human Human +DTXSID2025505 Css NA 3.943 mg/L 3compartmentss NA 95% Human Human +DTXSID2025505 Css NA 0.7083 mg/L PBTK NA 50% Human Human +DTXSID2025505 Css NA 4.502 mg/L PBTK NA 95% Human Human +DTXSID2025505 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025505 Fup 0.0358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025505 Vd NA 10.06 L/kg 1compartment NA NA Rat Human +DTXSID2025505 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID2025505 TK.Half.Life NA 27.64 hours 1compartment NA NA Rat Human +DTXSID2025505 Css NA 0.06098 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025505 Css NA 0.3845 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025505 Css NA 0.09006 mg/L PBTK NA 50% Rat Human +DTXSID2025505 Css NA 0.4708 mg/L PBTK NA 95% Rat Human +DTXSID2025551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025551 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025551 Vd NA 1.17 L/kg 1compartment NA NA Human Human +DTXSID2025551 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2025551 TK.Half.Life NA 1.89 hours 1compartment NA NA Human Human +DTXSID2025551 Css NA 0.1034 mg/L 3compartmentss NA 50% Human Human +DTXSID2025551 Css NA 0.7327 mg/L 3compartmentss NA 95% Human Human +DTXSID2025551 Css NA 0.07388 mg/L PBTK NA 50% Human Human +DTXSID2025551 Css NA 0.491 mg/L PBTK NA 95% Human Human +DTXSID2025551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025551 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025551 Vd NA 0.9529 L/kg 1compartment NA NA Rat Human +DTXSID2025551 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2025551 TK.Half.Life NA 0.801 hours 1compartment NA NA Rat Human +DTXSID2025551 Css NA 0.01308 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025551 Css NA 0.07023 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025551 Css NA 0.009234 mg/L PBTK NA 50% Rat Human +DTXSID2025551 Css NA 0.04654 mg/L PBTK NA 95% Rat Human +DTXSID2025557 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025557 Fup 0.802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025557 Vd NA 0.9494 L/kg 1compartment NA NA Human Human +DTXSID2025557 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2025557 TK.Half.Life NA 7.788 hours 1compartment NA NA Human Human +DTXSID2025557 Css NA 0.8068 mg/L 3compartmentss NA 50% Human Human +DTXSID2025557 Css NA 5.079 mg/L 3compartmentss NA 95% Human Human +DTXSID2025557 Css NA 0.6999 mg/L PBTK NA 50% Human Human +DTXSID2025557 Css NA 3.366 mg/L PBTK NA 95% Human Human +DTXSID2025557 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025557 Fup 0.802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025557 Vd NA 0.935 L/kg 1compartment NA NA Rat Human +DTXSID2025557 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2025557 TK.Half.Life NA 2.581 hours 1compartment NA NA Rat Human +DTXSID2025557 Css NA 0.01502 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025557 Css NA 0.1223 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025557 Css NA 0.01253 mg/L PBTK NA 50% Rat Human +DTXSID2025557 Css NA 0.08077 mg/L PBTK NA 95% Rat Human +DTXSID2025632 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025632 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025632 Vd NA 0.9693 L/kg 1compartment NA NA Human Human DTXSID2025632 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025632 TK.Half.Life NA 1.894 hours 1compartment NA NA Human Human -DTXSID2025632 Css NA 0.1307 mg/L 3compartmentss NA 50% Human Human -DTXSID2025632 Css NA 0.8921 mg/L 3compartmentss NA 95% Human Human -DTXSID2025632 Css NA 0.1028 mg/L PBTK NA 50% Human Human -DTXSID2025632 Css NA 0.6269 mg/L PBTK NA 95% Human Human -DTXSID2025632 Clint NA 8.039 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025632 Fup NA 0.4159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025632 Vd NA 0.955 L/kg 1compartment NA NA Rat Human +DTXSID2025632 TK.Half.Life NA 1.314 hours 1compartment NA NA Human Human +DTXSID2025632 Css NA 0.07338 mg/L 3compartmentss NA 50% Human Human +DTXSID2025632 Css NA 0.5592 mg/L 3compartmentss NA 95% Human Human +DTXSID2025632 Css NA 0.0534 mg/L PBTK NA 50% Human Human +DTXSID2025632 Css NA 0.3771 mg/L PBTK NA 95% Human Human +DTXSID2025632 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025632 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025632 Vd NA 0.8315 L/kg 1compartment NA NA Rat Human DTXSID2025632 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025632 TK.Half.Life NA 0.8864 hours 1compartment NA NA Rat Human -DTXSID2025632 Css NA 0.06514 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025632 Css NA 0.3578 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025632 Css NA 0.04966 mg/L PBTK NA 50% Rat Human -DTXSID2025632 Css NA 0.2288 mg/L PBTK NA 95% Rat Human -DTXSID2025634 Clint NA 5.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025634 Fup NA 0.3928 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025634 Vd NA 1.054 L/kg 1compartment NA NA Human Human +DTXSID2025632 TK.Half.Life NA 0.5879 hours 1compartment NA NA Rat Human +DTXSID2025632 Css NA 0.009187 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025632 Css NA 0.05194 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025632 Css NA 0.00672 mg/L PBTK NA 50% Rat Human +DTXSID2025632 Css NA 0.03423 mg/L PBTK NA 95% Rat Human +DTXSID2025634 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025634 Fup 0.274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025634 Vd NA 0.9541 L/kg 1compartment NA NA Human Human DTXSID2025634 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025634 TK.Half.Life NA 2.451 hours 1compartment NA NA Human Human -DTXSID2025634 Css NA 0.1977 mg/L 3compartmentss NA 50% Human Human -DTXSID2025634 Css NA 1.244 mg/L 3compartmentss NA 95% Human Human -DTXSID2025634 Css NA 0.1531 mg/L PBTK NA 50% Human Human -DTXSID2025634 Css NA 0.8551 mg/L PBTK NA 95% Human Human -DTXSID2025634 Clint NA 5.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025634 Fup NA 0.3928 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025634 Vd NA 0.9241 L/kg 1compartment NA NA Rat Human +DTXSID2025634 TK.Half.Life NA 1.314 hours 1compartment NA NA Human Human +DTXSID2025634 Css NA 0.07601 mg/L 3compartmentss NA 50% Human Human +DTXSID2025634 Css NA 0.5322 mg/L 3compartmentss NA 95% Human Human +DTXSID2025634 Css NA 0.05496 mg/L PBTK NA 50% Human Human +DTXSID2025634 Css NA 0.3572 mg/L PBTK NA 95% Human Human +DTXSID2025634 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025634 Fup 0.274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025634 Vd NA 0.8183 L/kg 1compartment NA NA Rat Human DTXSID2025634 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025634 TK.Half.Life NA 1.159 hours 1compartment NA NA Rat Human -DTXSID2025634 Css NA 0.09812 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025634 Css NA 0.4682 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025634 Css NA 0.07364 mg/L PBTK NA 50% Rat Human -DTXSID2025634 Css NA 0.2984 mg/L PBTK NA 95% Rat Human +DTXSID2025634 TK.Half.Life NA 0.5899 hours 1compartment NA NA Rat Human +DTXSID2025634 Css NA 0.009512 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025634 Css NA 0.05393 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025634 Css NA 0.006898 mg/L PBTK NA 50% Rat Human +DTXSID2025634 Css NA 0.03608 mg/L PBTK NA 95% Rat Human DTXSID2025688 Clint NA 1.151 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2025688 Fup NA 0.7477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2025688 Vd NA 1.686 L/kg 1compartment NA NA Human Human DTXSID2025688 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2025688 TK.Half.Life NA 5.398 hours 1compartment NA NA Human Human -DTXSID2025688 Css NA 0.3118 mg/L 3compartmentss NA 50% Human Human -DTXSID2025688 Css NA 2.197 mg/L 3compartmentss NA 95% Human Human -DTXSID2025688 Css NA 0.3006 mg/L PBTK NA 50% Human Human -DTXSID2025688 Css NA 1.534 mg/L PBTK NA 95% Human Human +DTXSID2025688 Css NA 0.2609 mg/L 3compartmentss NA 50% Human Human +DTXSID2025688 Css NA 1.875 mg/L 3compartmentss NA 95% Human Human +DTXSID2025688 Css NA 0.2513 mg/L PBTK NA 50% Human Human +DTXSID2025688 Css NA 1.315 mg/L PBTK NA 95% Human Human DTXSID2025688 Clint NA 1.151 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2025688 Fup NA 0.7477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2025688 Vd NA 1.717 L/kg 1compartment NA NA Rat Human DTXSID2025688 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2025688 TK.Half.Life NA 2.72 hours 1compartment NA NA Rat Human -DTXSID2025688 Css NA 0.1171 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025688 Css NA 0.8999 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025688 Css NA 0.1125 mg/L PBTK NA 50% Rat Human -DTXSID2025688 Css NA 0.5567 mg/L PBTK NA 95% Rat Human +DTXSID2025688 Css NA 0.007158 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025688 Css NA 0.0695 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025688 Css NA 0.006766 mg/L PBTK NA 50% Rat Human +DTXSID2025688 Css NA 0.04779 mg/L PBTK NA 95% Rat Human DTXSID2025715 Clint 23.36 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2025715 Fup 0.044 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2025715 Vd NA 0.8328 L/kg 1compartment NA NA Human Human +DTXSID2025715 Vd NA 0.8326 L/kg 1compartment NA NA Human Human DTXSID2025715 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025715 TK.Half.Life NA 3.263 hours 1compartment NA NA Human Human -DTXSID2025715 Css NA 0.1932 mg/L 3compartmentss NA 50% Human Human -DTXSID2025715 Css NA 2.4 mg/L 3compartmentss NA 95% Human Human -DTXSID2025715 Css NA 0.255 mg/L PBTK NA 50% Human Human -DTXSID2025715 Css NA 2.121 mg/L PBTK NA 95% Human Human +DTXSID2025715 TK.Half.Life NA 3.262 hours 1compartment NA NA Human Human +DTXSID2025715 Css NA 0.2325 mg/L 3compartmentss NA 50% Human Human +DTXSID2025715 Css NA 2.076 mg/L 3compartmentss NA 95% Human Human +DTXSID2025715 Css NA 0.3788 mg/L PBTK NA 50% Human Human +DTXSID2025715 Css NA 3.383 mg/L PBTK NA 95% Human Human DTXSID2025715 Clint 23.36 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2025715 Fup 0.044 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2025715 Vd NA 0.6412 L/kg 1compartment NA NA Rat Human +DTXSID2025715 Vd NA 0.6411 L/kg 1compartment NA NA Rat Human DTXSID2025715 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2025715 TK.Half.Life NA 1.55 hours 1compartment NA NA Rat Human -DTXSID2025715 Css NA 0.1562 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025715 Css NA 1.659 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025715 Css NA 0.2083 mg/L PBTK NA 50% Rat Human -DTXSID2025715 Css NA 1.357 mg/L PBTK NA 95% Rat Human -DTXSID2025761 Clint NA 7.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025761 Fup NA 0.0751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025761 Vd NA 2.364 L/kg 1compartment NA NA Human Human -DTXSID2025761 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2025761 TK.Half.Life NA 29.69 hours 1compartment NA NA Human Human -DTXSID2025761 Css NA 1.713 mg/L 3compartmentss NA 50% Human Human -DTXSID2025761 Css NA 9.893 mg/L 3compartmentss NA 95% Human Human -DTXSID2025761 Css NA 1.162 mg/L PBTK NA 50% Human Human -DTXSID2025761 Css NA 6.435 mg/L PBTK NA 95% Human Human -DTXSID2025761 Clint NA 7.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025761 Fup NA 0.0751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025761 Vd NA 1.777 L/kg 1compartment NA NA Rat Human -DTXSID2025761 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2025761 TK.Half.Life NA 7.861 hours 1compartment NA NA Rat Human -DTXSID2025761 Css NA 0.9272 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025761 Css NA 3.889 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025761 Css NA 0.5934 mg/L PBTK NA 50% Rat Human -DTXSID2025761 Css NA 2.396 mg/L PBTK NA 95% Rat Human -DTXSID2025763 Clint NA 6.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025763 Fup NA 0.4865 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025763 Vd NA 1.077 L/kg 1compartment NA NA Human Human +DTXSID2025715 Css NA 0.02898 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025715 Css NA 0.1868 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025715 Css NA 0.04893 mg/L PBTK NA 50% Rat Human +DTXSID2025715 Css NA 0.3153 mg/L PBTK NA 95% Rat Human +DTXSID2025761 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025761 Fup 0.0326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025761 Vd NA 1.844 L/kg 1compartment NA NA Human Human +DTXSID2025761 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2025761 TK.Half.Life NA 12.88 hours 1compartment NA NA Human Human +DTXSID2025761 Css NA 0.9938 mg/L 3compartmentss NA 50% Human Human +DTXSID2025761 Css NA 8.486 mg/L 3compartmentss NA 95% Human Human +DTXSID2025761 Css NA 0.6363 mg/L PBTK NA 50% Human Human +DTXSID2025761 Css NA 5.229 mg/L PBTK NA 95% Human Human +DTXSID2025761 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025761 Fup 0.0326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025761 Vd NA 1.375 L/kg 1compartment NA NA Rat Human +DTXSID2025761 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2025761 TK.Half.Life NA 4.429 hours 1compartment NA NA Rat Human +DTXSID2025761 Css NA 0.1294 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025761 Css NA 0.8129 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025761 Css NA 0.08094 mg/L PBTK NA 50% Rat Human +DTXSID2025761 Css NA 0.4959 mg/L PBTK NA 95% Rat Human +DTXSID2025763 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025763 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025763 Vd NA 0.8468 L/kg 1compartment NA NA Human Human DTXSID2025763 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025763 TK.Half.Life NA 1.832 hours 1compartment NA NA Human Human -DTXSID2025763 Css NA 0.1283 mg/L 3compartmentss NA 50% Human Human -DTXSID2025763 Css NA 0.9622 mg/L 3compartmentss NA 95% Human Human -DTXSID2025763 Css NA 0.1037 mg/L PBTK NA 50% Human Human -DTXSID2025763 Css NA 0.6581 mg/L PBTK NA 95% Human Human -DTXSID2025763 Clint NA 6.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025763 Fup NA 0.4865 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025763 Vd NA 0.9648 L/kg 1compartment NA NA Rat Human +DTXSID2025763 TK.Half.Life NA 1.08 hours 1compartment NA NA Human Human +DTXSID2025763 Css NA 0.0651 mg/L 3compartmentss NA 50% Human Human +DTXSID2025763 Css NA 0.5139 mg/L 3compartmentss NA 95% Human Human +DTXSID2025763 Css NA 0.04754 mg/L PBTK NA 50% Human Human +DTXSID2025763 Css NA 0.3463 mg/L PBTK NA 95% Human Human +DTXSID2025763 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025763 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025763 Vd NA 0.7535 L/kg 1compartment NA NA Rat Human DTXSID2025763 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025763 TK.Half.Life NA 0.8753 hours 1compartment NA NA Rat Human -DTXSID2025763 Css NA 0.06292 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025763 Css NA 0.3773 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025763 Css NA 0.04961 mg/L PBTK NA 50% Rat Human -DTXSID2025763 Css NA 0.2405 mg/L PBTK NA 95% Rat Human -DTXSID2025765 Clint NA 4.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025765 Fup NA 0.4135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025765 Vd NA 1.543 L/kg 1compartment NA NA Human Human +DTXSID2025763 TK.Half.Life NA 0.5016 hours 1compartment NA NA Rat Human +DTXSID2025763 Css NA 0.008127 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025763 Css NA 0.04687 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025763 Css NA 0.005931 mg/L PBTK NA 50% Rat Human +DTXSID2025763 Css NA 0.03128 mg/L PBTK NA 95% Rat Human +DTXSID2025765 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025765 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025765 Vd NA 1.148 L/kg 1compartment NA NA Human Human DTXSID2025765 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025765 TK.Half.Life NA 4.158 hours 1compartment NA NA Human Human -DTXSID2025765 Css NA 0.2366 mg/L 3compartmentss NA 50% Human Human -DTXSID2025765 Css NA 1.456 mg/L 3compartmentss NA 95% Human Human -DTXSID2025765 Css NA 0.1895 mg/L PBTK NA 50% Human Human -DTXSID2025765 Css NA 1.018 mg/L PBTK NA 95% Human Human -DTXSID2025765 Clint NA 4.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025765 Fup NA 0.4135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025765 Vd NA 1.271 L/kg 1compartment NA NA Rat Human +DTXSID2025765 TK.Half.Life NA 1.772 hours 1compartment NA NA Human Human +DTXSID2025765 Css NA 0.09528 mg/L 3compartmentss NA 50% Human Human +DTXSID2025765 Css NA 0.6621 mg/L 3compartmentss NA 95% Human Human +DTXSID2025765 Css NA 0.06856 mg/L PBTK NA 50% Human Human +DTXSID2025765 Css NA 0.4499 mg/L PBTK NA 95% Human Human +DTXSID2025765 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025765 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025765 Vd NA 0.9396 L/kg 1compartment NA NA Rat Human DTXSID2025765 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025765 TK.Half.Life NA 1.682 hours 1compartment NA NA Rat Human -DTXSID2025765 Css NA 0.1168 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025765 Css NA 0.5161 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025765 Css NA 0.0908 mg/L PBTK NA 50% Rat Human -DTXSID2025765 Css NA 0.3399 mg/L PBTK NA 95% Rat Human -DTXSID2025842 Clint NA 0.7014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025842 Fup NA 0.5239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025842 Vd NA 0.5782 L/kg 1compartment NA NA Human Human +DTXSID2025765 TK.Half.Life NA 0.7518 hours 1compartment NA NA Rat Human +DTXSID2025765 Css NA 0.012 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025765 Css NA 0.06468 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025765 Css NA 0.00856 mg/L PBTK NA 50% Rat Human +DTXSID2025765 Css NA 0.04324 mg/L PBTK NA 95% Rat Human +DTXSID2025842 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025842 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025842 Vd NA 0.6576 L/kg 1compartment NA NA Human Human DTXSID2025842 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025842 TK.Half.Life NA 3.447 hours 1compartment NA NA Human Human -DTXSID2025842 Css NA 0.6518 mg/L 3compartmentss NA 50% Human Human -DTXSID2025842 Css NA 3.833 mg/L 3compartmentss NA 95% Human Human -DTXSID2025842 Css NA 0.4913 mg/L PBTK NA 50% Human Human -DTXSID2025842 Css NA 2.412 mg/L PBTK NA 95% Human Human -DTXSID2025842 Clint NA 0.7014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025842 Fup NA 0.5239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025842 Vd NA 0.5623 L/kg 1compartment NA NA Rat Human +DTXSID2025842 TK.Half.Life NA 0.7307 hours 1compartment NA NA Human Human +DTXSID2025842 Css NA 0.04707 mg/L 3compartmentss NA 50% Human Human +DTXSID2025842 Css NA 0.3856 mg/L 3compartmentss NA 95% Human Human +DTXSID2025842 Css NA 0.03488 mg/L PBTK NA 50% Human Human +DTXSID2025842 Css NA 0.2593 mg/L PBTK NA 95% Human Human +DTXSID2025842 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025842 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025842 Vd NA 0.6069 L/kg 1compartment NA NA Rat Human DTXSID2025842 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025842 TK.Half.Life NA 1.538 hours 1compartment NA NA Rat Human -DTXSID2025842 Css NA 0.2486 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025842 Css NA 1.306 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025842 Css NA 0.1774 mg/L PBTK NA 50% Rat Human -DTXSID2025842 Css NA 0.7574 mg/L PBTK NA 95% Rat Human +DTXSID2025842 TK.Half.Life NA 0.3431 hours 1compartment NA NA Rat Human +DTXSID2025842 Css NA 0.005788 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025842 Css NA 0.03794 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025842 Css NA 0.004278 mg/L PBTK NA 50% Rat Human +DTXSID2025842 Css NA 0.02485 mg/L PBTK NA 95% Rat Human DTXSID2025892 Clint 57.9 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID2025892 Fup 0.006962 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID2025892 Vd NA 1.871 L/kg 1compartment NA NA Human Human DTXSID2025892 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID2025892 TK.Half.Life NA 14.46 hours 1compartment NA NA Human Human -DTXSID2025892 Css NA 0.9702 mg/L 3compartmentss NA 50% Human Human -DTXSID2025892 Css NA 7.559 mg/L 3compartmentss NA 95% Human Human -DTXSID2025892 Css NA 0.6204 mg/L PBTK NA 50% Human Human -DTXSID2025892 Css NA 4.647 mg/L PBTK NA 95% Human Human +DTXSID2025892 Css NA 0.9548 mg/L 3compartmentss NA 50% Human Human +DTXSID2025892 Css NA 7.48 mg/L 3compartmentss NA 95% Human Human +DTXSID2025892 Css NA 0.6126 mg/L PBTK NA 50% Human Human +DTXSID2025892 Css NA 4.662 mg/L PBTK NA 95% Human Human DTXSID2025892 Clint 57.9 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID2025892 Fup 0.006962 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID2025892 Vd NA 1.383 L/kg 1compartment NA NA Rat Human DTXSID2025892 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2025892 TK.Half.Life NA 4.902 hours 1compartment NA NA Rat Human -DTXSID2025892 Css NA 0.5666 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025892 Css NA 3.356 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025892 Css NA 0.3396 mg/L PBTK NA 50% Rat Human -DTXSID2025892 Css NA 1.943 mg/L PBTK NA 95% Rat Human -DTXSID2025896 Clint NA 6.122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025896 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025896 Vd NA 3.429 L/kg 1compartment NA NA Human Human -DTXSID2025896 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025896 TK.Half.Life NA 3.007 hours 1compartment NA NA Human Human -DTXSID2025896 Css NA 0.05456 mg/L 3compartmentss NA 50% Human Human -DTXSID2025896 Css NA 0.6111 mg/L 3compartmentss NA 95% Human Human -DTXSID2025896 Css NA 0.06604 mg/L PBTK NA 50% Human Human -DTXSID2025896 Css NA 0.5282 mg/L PBTK NA 95% Human Human -DTXSID2025896 Clint NA 6.122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025896 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025896 Vd NA 3.498 L/kg 1compartment NA NA Rat Human +DTXSID2025892 Css NA 0.1262 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025892 Css NA 0.8026 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025892 Css NA 0.0787 mg/L PBTK NA 50% Rat Human +DTXSID2025892 Css NA 0.4859 mg/L PBTK NA 95% Rat Human +DTXSID2025896 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025896 Fup 0.572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025896 Vd NA 1.743 L/kg 1compartment NA NA Human Human +DTXSID2025896 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2025896 TK.Half.Life NA 19.72 hours 1compartment NA NA Human Human +DTXSID2025896 Css NA 1.042 mg/L 3compartmentss NA 50% Human Human +DTXSID2025896 Css NA 8.185 mg/L 3compartmentss NA 95% Human Human +DTXSID2025896 Css NA 0.9916 mg/L PBTK NA 50% Human Human +DTXSID2025896 Css NA 5.524 mg/L PBTK NA 95% Human Human +DTXSID2025896 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025896 Fup 0.572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025896 Vd NA 1.763 L/kg 1compartment NA NA Rat Human DTXSID2025896 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025896 TK.Half.Life NA 1.674 hours 1compartment NA NA Rat Human -DTXSID2025896 Css NA 0.02462 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025896 Css NA 0.234 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025896 Css NA 0.03081 mg/L PBTK NA 50% Rat Human -DTXSID2025896 Css NA 0.1779 mg/L PBTK NA 95% Rat Human -DTXSID2025925 Clint NA 155.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025925 Fup NA 0.446 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025925 Vd NA 1.286 L/kg 1compartment NA NA Human Human +DTXSID2025896 TK.Half.Life NA 6.796 hours 1compartment NA NA Rat Human +DTXSID2025896 Css NA 0.06302 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025896 Css NA 0.4474 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025896 Css NA 0.06054 mg/L PBTK NA 50% Rat Human +DTXSID2025896 Css NA 0.2882 mg/L PBTK NA 95% Rat Human +DTXSID2025925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025925 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025925 Vd NA 1.271 L/kg 1compartment NA NA Human Human DTXSID2025925 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025925 TK.Half.Life NA 0.9242 hours 1compartment NA NA Human Human -DTXSID2025925 Css NA 0.006882 mg/L 3compartmentss NA 50% Human Human -DTXSID2025925 Css NA 0.06002 mg/L 3compartmentss NA 95% Human Human -DTXSID2025925 Css NA 0.005552 mg/L PBTK NA 50% Human Human -DTXSID2025925 Css NA 0.04259 mg/L PBTK NA 95% Human Human -DTXSID2025925 Clint NA 155.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025925 Fup NA 0.446 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025925 Vd NA 1.103 L/kg 1compartment NA NA Rat Human +DTXSID2025925 TK.Half.Life NA 1.666 hours 1compartment NA NA Human Human +DTXSID2025925 Css NA 0.06856 mg/L 3compartmentss NA 50% Human Human +DTXSID2025925 Css NA 0.5296 mg/L 3compartmentss NA 95% Human Human +DTXSID2025925 Css NA 0.05197 mg/L PBTK NA 50% Human Human +DTXSID2025925 Css NA 0.3596 mg/L PBTK NA 95% Human Human +DTXSID2025925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025925 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025925 Vd NA 1.054 L/kg 1compartment NA NA Rat Human DTXSID2025925 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025925 TK.Half.Life NA 0.3531 hours 1compartment NA NA Rat Human -DTXSID2025925 Css NA 0.003714 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025925 Css NA 0.0264 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025925 Css NA 0.002908 mg/L PBTK NA 50% Rat Human -DTXSID2025925 Css NA 0.01816 mg/L PBTK NA 95% Rat Human -DTXSID2025977 Clint NA 1.031 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025977 Fup NA 0.9318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2025977 Vd NA 1.073 L/kg 1compartment NA NA Human Human +DTXSID2025925 TK.Half.Life NA 0.6964 hours 1compartment NA NA Rat Human +DTXSID2025925 Css NA 0.008689 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025925 Css NA 0.05003 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025925 Css NA 0.006575 mg/L PBTK NA 50% Rat Human +DTXSID2025925 Css NA 0.03412 mg/L PBTK NA 95% Rat Human +DTXSID2025977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025977 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2025977 Vd NA 0.7833 L/kg 1compartment NA NA Human Human DTXSID2025977 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2025977 TK.Half.Life NA 3.052 hours 1compartment NA NA Human Human -DTXSID2025977 Css NA 0.3035 mg/L 3compartmentss NA 50% Human Human -DTXSID2025977 Css NA 1.329 mg/L 3compartmentss NA 95% Human Human -DTXSID2025977 Css NA 0.2691 mg/L PBTK NA 50% Human Human -DTXSID2025977 Css NA 0.9771 mg/L PBTK NA 95% Human Human -DTXSID2025977 Clint NA 1.031 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025977 Fup NA 0.9318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2025977 Vd NA 1.042 L/kg 1compartment NA NA Rat Human +DTXSID2025977 TK.Half.Life NA 0.8034 hours 1compartment NA NA Human Human +DTXSID2025977 Css NA 0.04001 mg/L 3compartmentss NA 50% Human Human +DTXSID2025977 Css NA 0.3691 mg/L 3compartmentss NA 95% Human Human +DTXSID2025977 Css NA 0.03122 mg/L PBTK NA 50% Human Human +DTXSID2025977 Css NA 0.2514 mg/L PBTK NA 95% Human Human +DTXSID2025977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025977 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2025977 Vd NA 0.7412 L/kg 1compartment NA NA Rat Human DTXSID2025977 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2025977 TK.Half.Life NA 1.405 hours 1compartment NA NA Rat Human -DTXSID2025977 Css NA 0.1155 mg/L 3compartmentss NA 50% Rat Human -DTXSID2025977 Css NA 0.4247 mg/L 3compartmentss NA 95% Rat Human -DTXSID2025977 Css NA 0.1016 mg/L PBTK NA 50% Rat Human -DTXSID2025977 Css NA 0.2866 mg/L PBTK NA 95% Rat Human -DTXSID2026022 Clint NA 0.1028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026022 Fup NA 0.2182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026022 Vd NA 0.29 L/kg 1compartment NA NA Human Human -DTXSID2026022 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026022 TK.Half.Life NA 7.35 hours 1compartment NA NA Human Human -DTXSID2026022 Css NA 3.14 mg/L 3compartmentss NA 50% Human Human -DTXSID2026022 Css NA 11.47 mg/L 3compartmentss NA 95% Human Human -DTXSID2026022 Css NA 2.015 mg/L PBTK NA 50% Human Human -DTXSID2026022 Css NA 6.913 mg/L PBTK NA 95% Human Human -DTXSID2026022 Clint NA 0.1028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026022 Fup NA 0.2182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026022 Vd NA 0.2927 L/kg 1compartment NA NA Rat Human -DTXSID2026022 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026022 TK.Half.Life NA 2.732 hours 1compartment NA NA Rat Human -DTXSID2026022 Css NA 0.969 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026022 Css NA 2.975 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026022 Css NA 0.584 mg/L PBTK NA 50% Rat Human -DTXSID2026022 Css NA 1.673 mg/L PBTK NA 95% Rat Human -DTXSID2026074 Clint NA 135.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026074 Fup NA 0.0192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026074 Vd NA 2.748 L/kg 1compartment NA NA Human Human -DTXSID2026074 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026074 TK.Half.Life NA 8.612 hours 1compartment NA NA Human Human -DTXSID2026074 Css NA 0.3304 mg/L 3compartmentss NA 50% Human Human -DTXSID2026074 Css NA 2.454 mg/L 3compartmentss NA 95% Human Human -DTXSID2026074 Css NA 0.2227 mg/L PBTK NA 50% Human Human -DTXSID2026074 Css NA 1.585 mg/L PBTK NA 95% Human Human -DTXSID2026074 Clint NA 135.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026074 Fup NA 0.0192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026074 Vd NA 2.054 L/kg 1compartment NA NA Rat Human -DTXSID2026074 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026074 TK.Half.Life NA 2.011 hours 1compartment NA NA Rat Human -DTXSID2026074 Css NA 0.1864 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026074 Css NA 1.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026074 Css NA 0.1191 mg/L PBTK NA 50% Rat Human -DTXSID2026074 Css NA 0.6693 mg/L PBTK NA 95% Rat Human -DTXSID2026076 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID2026076 Fup 1 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID2026076 Vd NA 0.6639 L/kg 1compartment NA NA Human Human -DTXSID2026076 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026076 TK.Half.Life NA 4.297 hours 1compartment NA NA Human Human -DTXSID2026076 Css NA 0.855 mg/L 3compartmentss NA 50% Human Human -DTXSID2026076 Css NA 5.585 mg/L 3compartmentss NA 95% Human Human -DTXSID2026076 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID2026076 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID2026076 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID2026076 Fup 1 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID2026076 Vd NA 0.7212 L/kg 1compartment NA NA Rat Human -DTXSID2026076 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026076 TK.Half.Life NA 1.59 hours 1compartment NA NA Rat Human -DTXSID2026076 Css NA 0.215 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026076 Css NA 1.343 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026076 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID2026076 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID2026101 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026101 Fup NA 0.0059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026101 Vd NA 0.4377 L/kg 1compartment NA NA Human Human -DTXSID2026101 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID2026101 TK.Half.Life NA 52.91 hours 1compartment NA NA Human Human -DTXSID2026101 Css NA 22.82 mg/L 3compartmentss NA 50% Human Human -DTXSID2026101 Css NA 181.3 mg/L 3compartmentss NA 95% Human Human -DTXSID2026101 Css NA 13.48 mg/L PBTK NA 50% Human Human -DTXSID2026101 Css NA 104 mg/L PBTK NA 95% Human Human -DTXSID2026101 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026101 Fup NA 0.0059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026101 Vd NA 0.3357 L/kg 1compartment NA NA Rat Human -DTXSID2026101 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2026101 TK.Half.Life NA 24.94 hours 1compartment NA NA Rat Human -DTXSID2026101 Css NA 11.76 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026101 Css NA 76.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026101 Css NA 6.444 mg/L PBTK NA 50% Rat Human -DTXSID2026101 Css NA 41.36 mg/L PBTK NA 95% Rat Human -DTXSID2026107 Clint NA 2.757 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026107 Fup NA 0.4362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026107 Vd NA 0.9743 L/kg 1compartment NA NA Human Human +DTXSID2025977 TK.Half.Life NA 0.3842 hours 1compartment NA NA Rat Human +DTXSID2025977 Css NA 0.004994 mg/L 3compartmentss NA 50% Rat Human +DTXSID2025977 Css NA 0.03581 mg/L 3compartmentss NA 95% Rat Human +DTXSID2025977 Css NA 0.003868 mg/L PBTK NA 50% Rat Human +DTXSID2025977 Css NA 0.02361 mg/L PBTK NA 95% Rat Human +DTXSID2026074 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026074 Fup 0.0311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026074 Vd NA 2.817 L/kg 1compartment NA NA Human Human +DTXSID2026074 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2026074 TK.Half.Life NA 35.93 hours 1compartment NA NA Human Human +DTXSID2026074 Css NA 1.643 mg/L 3compartmentss NA 50% Human Human +DTXSID2026074 Css NA 11.14 mg/L 3compartmentss NA 95% Human Human +DTXSID2026074 Css NA 1.116 mg/L PBTK NA 50% Human Human +DTXSID2026074 Css NA 7.308 mg/L PBTK NA 95% Human Human +DTXSID2026074 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026074 Fup 0.0311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026074 Vd NA 2.109 L/kg 1compartment NA NA Rat Human +DTXSID2026074 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2026074 TK.Half.Life NA 7.025 hours 1compartment NA NA Rat Human +DTXSID2026074 Css NA 0.2114 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026074 Css NA 1.17 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026074 Css NA 0.1417 mg/L PBTK NA 50% Rat Human +DTXSID2026074 Css NA 0.7711 mg/L PBTK NA 95% Rat Human +DTXSID2026101 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026101 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026101 Vd NA 0.6146 L/kg 1compartment NA NA Human Human +DTXSID2026101 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2026101 TK.Half.Life NA 8.258 hours 1compartment NA NA Human Human +DTXSID2026101 Css NA 2.314 mg/L 3compartmentss NA 50% Human Human +DTXSID2026101 Css NA 22.44 mg/L 3compartmentss NA 95% Human Human +DTXSID2026101 Css NA 1.372 mg/L PBTK NA 50% Human Human +DTXSID2026101 Css NA 13.17 mg/L PBTK NA 95% Human Human +DTXSID2026101 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026101 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026101 Vd NA 0.4631 L/kg 1compartment NA NA Rat Human +DTXSID2026101 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2026101 TK.Half.Life NA 3.965 hours 1compartment NA NA Rat Human +DTXSID2026101 Css NA 0.3018 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026101 Css NA 2.292 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026101 Css NA 0.174 mg/L PBTK NA 50% Rat Human +DTXSID2026101 Css NA 1.293 mg/L PBTK NA 95% Rat Human +DTXSID2026107 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026107 Fup 0.475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026107 Vd NA 1.023 L/kg 1compartment NA NA Human Human DTXSID2026107 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026107 TK.Half.Life NA 3.139 hours 1compartment NA NA Human Human -DTXSID2026107 Css NA 0.3095 mg/L 3compartmentss NA 50% Human Human -DTXSID2026107 Css NA 1.81 mg/L 3compartmentss NA 95% Human Human -DTXSID2026107 Css NA 0.2424 mg/L PBTK NA 50% Human Human -DTXSID2026107 Css NA 1.217 mg/L PBTK NA 95% Human Human -DTXSID2026107 Clint NA 2.757 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026107 Fup NA 0.4362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026107 Vd NA 0.8785 L/kg 1compartment NA NA Rat Human +DTXSID2026107 TK.Half.Life NA 1.033 hours 1compartment NA NA Human Human +DTXSID2026107 Css NA 0.03968 mg/L 3compartmentss NA 50% Human Human +DTXSID2026107 Css NA 0.345 mg/L 3compartmentss NA 95% Human Human +DTXSID2026107 Css NA 0.03206 mg/L PBTK NA 50% Human Human +DTXSID2026107 Css NA 0.244 mg/L PBTK NA 95% Human Human +DTXSID2026107 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026107 Fup 0.475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026107 Vd NA 0.9236 L/kg 1compartment NA NA Rat Human DTXSID2026107 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026107 TK.Half.Life NA 1.501 hours 1compartment NA NA Rat Human -DTXSID2026107 Css NA 0.1418 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026107 Css NA 0.6655 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026107 Css NA 0.1079 mg/L PBTK NA 50% Rat Human -DTXSID2026107 Css NA 0.4183 mg/L PBTK NA 95% Rat Human -DTXSID2026151 Clint NA 46.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026151 Fup NA 0.0032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026151 Vd NA 2010 L/kg 1compartment NA NA Human Human -DTXSID2026151 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID2026151 TK.Half.Life NA 27650 hours 1compartment NA NA Human Human -DTXSID2026151 Css NA 0.00384 mg/L 3compartmentss NA 50% Human Human -DTXSID2026151 Css NA 0.02785 mg/L 3compartmentss NA 95% Human Human -DTXSID2026151 Css NA 1.243 mg/L PBTK NA 50% Human Human -DTXSID2026151 Css NA 7.084 mg/L PBTK NA 95% Human Human -DTXSID2026151 Clint NA 46.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026151 Fup NA 0.0032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026151 Vd NA 1861 L/kg 1compartment NA NA Rat Human -DTXSID2026151 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID2026151 TK.Half.Life NA 5208 hours 1compartment NA NA Rat Human -DTXSID2026151 Css NA 0.001874 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026151 Css NA 0.01095 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026151 Css NA 0.6629 mg/L PBTK NA 50% Rat Human -DTXSID2026151 Css NA 2.974 mg/L PBTK NA 95% Rat Human +DTXSID2026107 TK.Half.Life NA 0.4677 hours 1compartment NA NA Rat Human +DTXSID2026107 Css NA 0.004882 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026107 Css NA 0.03431 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026107 Css NA 0.003931 mg/L PBTK NA 50% Rat Human +DTXSID2026107 Css NA 0.02415 mg/L PBTK NA 95% Rat Human DTXSID2026157 Clint NA 13.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2026157 Fup NA 0.33 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026157 Vd NA 0.5902 L/kg 1compartment NA NA Human Human +DTXSID2026157 Vd NA 0.5814 L/kg 1compartment NA NA Human Human DTXSID2026157 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026157 TK.Half.Life NA 0.9193 hours 1compartment NA NA Human Human -DTXSID2026157 Css NA 0.1047 mg/L 3compartmentss NA 50% Human Human -DTXSID2026157 Css NA 0.7422 mg/L 3compartmentss NA 95% Human Human -DTXSID2026157 Css NA 0.07494 mg/L PBTK NA 50% Human Human -DTXSID2026157 Css NA 0.4906 mg/L PBTK NA 95% Human Human +DTXSID2026157 TK.Half.Life NA 0.9061 hours 1compartment NA NA Human Human +DTXSID2026157 Css NA 0.1009 mg/L 3compartmentss NA 50% Human Human +DTXSID2026157 Css NA 0.7329 mg/L 3compartmentss NA 95% Human Human +DTXSID2026157 Css NA 0.07214 mg/L PBTK NA 50% Human Human +DTXSID2026157 Css NA 0.4805 mg/L PBTK NA 95% Human Human DTXSID2026157 Clint NA 13.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2026157 Fup NA 0.33 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026157 Vd NA 0.571 L/kg 1compartment NA NA Rat Human +DTXSID2026157 Vd NA 0.5646 L/kg 1compartment NA NA Rat Human DTXSID2026157 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026157 TK.Half.Life NA 0.4861 hours 1compartment NA NA Rat Human -DTXSID2026157 Css NA 0.05577 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026157 Css NA 0.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026157 Css NA 0.03828 mg/L PBTK NA 50% Rat Human -DTXSID2026157 Css NA 0.1889 mg/L PBTK NA 95% Rat Human -DTXSID2026232 Clint NA 3.093 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026232 Fup NA 0.1699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026232 Vd NA 0.5278 L/kg 1compartment NA NA Human Human -DTXSID2026232 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026232 TK.Half.Life NA 3.605 hours 1compartment NA NA Human Human -DTXSID2026232 Css NA 0.8084 mg/L 3compartmentss NA 50% Human Human -DTXSID2026232 Css NA 4.089 mg/L 3compartmentss NA 95% Human Human -DTXSID2026232 Css NA 0.5306 mg/L PBTK NA 50% Human Human -DTXSID2026232 Css NA 2.544 mg/L PBTK NA 95% Human Human -DTXSID2026232 Clint NA 3.093 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026232 Fup NA 0.1699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026232 Vd NA 0.4645 L/kg 1compartment NA NA Rat Human +DTXSID2026157 TK.Half.Life NA 0.481 hours 1compartment NA NA Rat Human +DTXSID2026157 Css NA 0.01228 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026157 Css NA 0.06535 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026157 Css NA 0.008765 mg/L PBTK NA 50% Rat Human +DTXSID2026157 Css NA 0.04212 mg/L PBTK NA 95% Rat Human +DTXSID2026232 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026232 Fup 0.37 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026232 Vd NA 0.7022 L/kg 1compartment NA NA Human Human +DTXSID2026232 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2026232 TK.Half.Life NA 12.66 hours 1compartment NA NA Human Human +DTXSID2026232 Css NA 1.965 mg/L 3compartmentss NA 50% Human Human +DTXSID2026232 Css NA 8.31 mg/L 3compartmentss NA 95% Human Human +DTXSID2026232 Css NA 1.439 mg/L PBTK NA 50% Human Human +DTXSID2026232 Css NA 5.277 mg/L PBTK NA 95% Human Human +DTXSID2026232 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026232 Fup 0.37 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026232 Vd NA 0.6362 L/kg 1compartment NA NA Rat Human DTXSID2026232 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026232 TK.Half.Life NA 1.796 hours 1compartment NA NA Rat Human -DTXSID2026232 Css NA 0.3902 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026232 Css NA 1.415 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026232 Css NA 0.243 mg/L PBTK NA 50% Rat Human -DTXSID2026232 Css NA 0.8146 mg/L PBTK NA 95% Rat Human -DTXSID2026444 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026444 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026444 Vd NA 0.7899 L/kg 1compartment NA NA Human Human +DTXSID2026232 TK.Half.Life NA 3.819 hours 1compartment NA NA Rat Human +DTXSID2026232 Css NA 0.1268 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026232 Css NA 0.4526 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026232 Css NA 0.09144 mg/L PBTK NA 50% Rat Human +DTXSID2026232 Css NA 0.2771 mg/L PBTK NA 95% Rat Human +DTXSID2026444 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026444 Fup 0.858 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026444 Vd NA 0.7103 L/kg 1compartment NA NA Human Human DTXSID2026444 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026444 TK.Half.Life NA 5.112 hours 1compartment NA NA Human Human -DTXSID2026444 Css NA 0.8248 mg/L 3compartmentss NA 50% Human Human -DTXSID2026444 Css NA 5.555 mg/L 3compartmentss NA 95% Human Human -DTXSID2026444 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID2026444 Css NA 3.599 mg/L PBTK NA 95% Human Human -DTXSID2026444 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026444 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026444 Vd NA 0.8261 L/kg 1compartment NA NA Rat Human +DTXSID2026444 TK.Half.Life NA 5.357 hours 1compartment NA NA Human Human +DTXSID2026444 Css NA 0.8216 mg/L 3compartmentss NA 50% Human Human +DTXSID2026444 Css NA 5.143 mg/L 3compartmentss NA 95% Human Human +DTXSID2026444 Css NA 0.6732 mg/L PBTK NA 50% Human Human +DTXSID2026444 Css NA 3.339 mg/L PBTK NA 95% Human Human +DTXSID2026444 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026444 Fup 0.858 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026444 Vd NA 0.744 L/kg 1compartment NA NA Rat Human DTXSID2026444 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026444 TK.Half.Life NA 1.822 hours 1compartment NA NA Rat Human -DTXSID2026444 Css NA 0.2074 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026444 Css NA 1.328 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026444 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID2026444 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID2026444 TK.Half.Life NA 1.912 hours 1compartment NA NA Rat Human +DTXSID2026444 Css NA 0.0153 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026444 Css NA 0.1117 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026444 Css NA 0.012 mg/L PBTK NA 50% Rat Human +DTXSID2026444 Css NA 0.07339 mg/L PBTK NA 95% Rat Human DTXSID2026446 Clint 261 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2026446 Fup 0.00942 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2026446 Vd NA 2.3 L/kg 1compartment NA NA Human Human +DTXSID2026446 Vd NA 2.827 L/kg 1compartment NA NA Human Human DTXSID2026446 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026446 TK.Half.Life NA 5.134 hours 1compartment NA NA Human Human -DTXSID2026446 Css NA 0.1692 mg/L 3compartmentss NA 50% Human Human -DTXSID2026446 Css NA 1.125 mg/L 3compartmentss NA 95% Human Human -DTXSID2026446 Css NA 0.112 mg/L PBTK NA 50% Human Human -DTXSID2026446 Css NA 0.7234 mg/L PBTK NA 95% Human Human +DTXSID2026446 TK.Half.Life NA 7.193 hours 1compartment NA NA Human Human +DTXSID2026446 Css NA 0.2036 mg/L 3compartmentss NA 50% Human Human +DTXSID2026446 Css NA 1.379 mg/L 3compartmentss NA 95% Human Human +DTXSID2026446 Css NA 0.1386 mg/L PBTK NA 50% Human Human +DTXSID2026446 Css NA 0.9345 mg/L PBTK NA 95% Human Human DTXSID2026446 Clint 261 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2026446 Fup 0.00942 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2026446 Vd NA 1.709 L/kg 1compartment NA NA Rat Human +DTXSID2026446 Vd NA 2.112 L/kg 1compartment NA NA Rat Human DTXSID2026446 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026446 TK.Half.Life NA 1.516 hours 1compartment NA NA Rat Human -DTXSID2026446 Css NA 0.09516 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026446 Css NA 0.5326 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026446 Css NA 0.06005 mg/L PBTK NA 50% Rat Human -DTXSID2026446 Css NA 0.3305 mg/L PBTK NA 95% Rat Human -DTXSID2026448 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026448 Fup NA 0.9916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026448 Vd NA 0.7449 L/kg 1compartment NA NA Human Human +DTXSID2026446 TK.Half.Life NA 1.664 hours 1compartment NA NA Rat Human +DTXSID2026446 Css NA 0.0267 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026446 Css NA 0.1603 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026446 Css NA 0.01802 mg/L PBTK NA 50% Rat Human +DTXSID2026446 Css NA 0.1069 mg/L PBTK NA 95% Rat Human +DTXSID2026448 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026448 Fup 0.831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026448 Vd NA 0.67 L/kg 1compartment NA NA Human Human DTXSID2026448 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026448 TK.Half.Life NA 4.861 hours 1compartment NA NA Human Human -DTXSID2026448 Css NA 0.8263 mg/L 3compartmentss NA 50% Human Human -DTXSID2026448 Css NA 5.852 mg/L 3compartmentss NA 95% Human Human -DTXSID2026448 Css NA 0.6942 mg/L PBTK NA 50% Human Human -DTXSID2026448 Css NA 3.759 mg/L PBTK NA 95% Human Human -DTXSID2026448 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026448 Fup NA 0.9916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026448 Vd NA 0.7867 L/kg 1compartment NA NA Rat Human +DTXSID2026448 TK.Half.Life NA 5.216 hours 1compartment NA NA Human Human +DTXSID2026448 Css NA 0.8397 mg/L 3compartmentss NA 50% Human Human +DTXSID2026448 Css NA 5.215 mg/L 3compartmentss NA 95% Human Human +DTXSID2026448 Css NA 0.6816 mg/L PBTK NA 50% Human Human +DTXSID2026448 Css NA 3.34 mg/L PBTK NA 95% Human Human +DTXSID2026448 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026448 Fup 0.831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026448 Vd NA 0.7073 L/kg 1compartment NA NA Rat Human DTXSID2026448 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026448 TK.Half.Life NA 1.749 hours 1compartment NA NA Rat Human -DTXSID2026448 Css NA 0.2092 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026448 Css NA 1.295 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026448 Css NA 0.1717 mg/L PBTK NA 50% Rat Human -DTXSID2026448 Css NA 0.7793 mg/L PBTK NA 95% Rat Human +DTXSID2026448 TK.Half.Life NA 1.877 hours 1compartment NA NA Rat Human +DTXSID2026448 Css NA 0.01582 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026448 Css NA 0.1163 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026448 Css NA 0.01237 mg/L PBTK NA 50% Rat Human +DTXSID2026448 Css NA 0.07643 mg/L PBTK NA 95% Rat Human +DTXSID2026494 Clint NA 5.211 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2026494 Fup NA 0.0111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2026494 Vd NA 2.73 L/kg 1compartment NA NA Human Human +DTXSID2026494 Days.Css NA 41 Days PBTK NA NA Human Human +DTXSID2026494 TK.Half.Life NA 203.2 hours 1compartment NA NA Human Human +DTXSID2026494 Css NA 9.046 mg/L 3compartmentss NA 50% Human Human +DTXSID2026494 Css NA 56.91 mg/L 3compartmentss NA 95% Human Human +DTXSID2026494 Css NA 6.05 mg/L PBTK NA 50% Human Human +DTXSID2026494 Css NA 37.02 mg/L PBTK NA 95% Human Human +DTXSID2026494 Clint NA 5.211 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2026494 Fup NA 0.0111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2026494 Vd NA 2.038 L/kg 1compartment NA NA Rat Human +DTXSID2026494 Days.Css NA 22 Days PBTK NA NA Rat Human +DTXSID2026494 TK.Half.Life NA 40.32 hours 1compartment NA NA Rat Human +DTXSID2026494 Css NA 0.3404 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026494 Css NA 2.428 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026494 Css NA 0.2178 mg/L PBTK NA 50% Rat Human +DTXSID2026494 Css NA 1.502 mg/L PBTK NA 95% Rat Human DTXSID2026523 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2026523 Fup NA 0.6089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026523 Vd NA 0.5169 L/kg 1compartment NA NA Human Human +DTXSID2026523 Vd NA 0.4432 L/kg 1compartment NA NA Human Human DTXSID2026523 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026523 TK.Half.Life NA 5.501 hours 1compartment NA NA Human Human -DTXSID2026523 Css NA 1.284 mg/L 3compartmentss NA 50% Human Human -DTXSID2026523 Css NA 8.499 mg/L 3compartmentss NA 95% Human Human -DTXSID2026523 Css NA 0.9688 mg/L PBTK NA 50% Human Human -DTXSID2026523 Css NA 5.328 mg/L PBTK NA 95% Human Human +DTXSID2026523 TK.Half.Life NA 4.709 hours 1compartment NA NA Human Human +DTXSID2026523 Css NA 1.283 mg/L 3compartmentss NA 50% Human Human +DTXSID2026523 Css NA 8.347 mg/L 3compartmentss NA 95% Human Human +DTXSID2026523 Css NA 0.9364 mg/L PBTK NA 50% Human Human +DTXSID2026523 Css NA 5.126 mg/L PBTK NA 95% Human Human DTXSID2026523 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2026523 Fup NA 0.6089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026523 Vd NA 0.5201 L/kg 1compartment NA NA Rat Human +DTXSID2026523 Vd NA 0.454 L/kg 1compartment NA NA Rat Human DTXSID2026523 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026523 TK.Half.Life NA 1.884 hours 1compartment NA NA Rat Human -DTXSID2026523 Css NA 0.3384 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026523 Css NA 2.051 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026523 Css NA 0.2444 mg/L PBTK NA 50% Rat Human -DTXSID2026523 Css NA 1.184 mg/L PBTK NA 95% Rat Human +DTXSID2026523 TK.Half.Life NA 1.644 hours 1compartment NA NA Rat Human +DTXSID2026523 Css NA 0.07953 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026523 Css NA 0.4688 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026523 Css NA 0.05715 mg/L PBTK NA 50% Rat Human +DTXSID2026523 Css NA 0.2775 mg/L PBTK NA 95% Rat Human DTXSID2026525 Clint 59.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2026525 Fup 0.000115 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2026525 Vd NA 0.1901 L/kg 1compartment NA NA Human Human DTXSID2026525 Days.Css NA 15 Days PBTK NA NA Human Human DTXSID2026525 TK.Half.Life NA 76.3 hours 1compartment NA NA Human Human -DTXSID2026525 Css NA 52 mg/L 3compartmentss NA 50% Human Human -DTXSID2026525 Css NA 279.4 mg/L 3compartmentss NA 95% Human Human -DTXSID2026525 Css NA 29.98 mg/L PBTK NA 50% Human Human -DTXSID2026525 Css NA 161.2 mg/L PBTK NA 95% Human Human +DTXSID2026525 Css NA 50.41 mg/L 3compartmentss NA 50% Human Human +DTXSID2026525 Css NA 280.3 mg/L 3compartmentss NA 95% Human Human +DTXSID2026525 Css NA 29.18 mg/L PBTK NA 50% Human Human +DTXSID2026525 Css NA 162.2 mg/L PBTK NA 95% Human Human DTXSID2026525 Clint 59.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2026525 Fup 0.000115 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2026525 Vd NA 0.1733 L/kg 1compartment NA NA Rat Human DTXSID2026525 Days.Css NA 8 Days PBTK NA NA Rat Human DTXSID2026525 TK.Half.Life NA 48.34 hours 1compartment NA NA Rat Human -DTXSID2026525 Css NA 30.93 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026525 Css NA 108.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026525 Css NA 16.71 mg/L PBTK NA 50% Rat Human -DTXSID2026525 Css NA 58.71 mg/L PBTK NA 95% Rat Human -DTXSID2026527 Clint NA 3.472 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026527 Fup NA 0.1655 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026527 Vd NA 0.2921 L/kg 1compartment NA NA Human Human +DTXSID2026525 Css NA 6.967 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026525 Css NA 29.77 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026525 Css NA 3.899 mg/L PBTK NA 50% Rat Human +DTXSID2026525 Css NA 16.67 mg/L PBTK NA 95% Rat Human +DTXSID2026527 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026527 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026527 Vd NA 0.3595 L/kg 1compartment NA NA Human Human DTXSID2026527 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026527 TK.Half.Life NA 1.568 hours 1compartment NA NA Human Human -DTXSID2026527 Css NA 0.6534 mg/L 3compartmentss NA 50% Human Human -DTXSID2026527 Css NA 3.586 mg/L 3compartmentss NA 95% Human Human -DTXSID2026527 Css NA 0.4132 mg/L PBTK NA 50% Human Human -DTXSID2026527 Css NA 2.185 mg/L PBTK NA 95% Human Human -DTXSID2026527 Clint NA 3.472 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026527 Fup NA 0.1655 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026527 Vd NA 0.3019 L/kg 1compartment NA NA Rat Human +DTXSID2026527 TK.Half.Life NA 0.8673 hours 1compartment NA NA Human Human +DTXSID2026527 Css NA 0.2118 mg/L 3compartmentss NA 50% Human Human +DTXSID2026527 Css NA 1.365 mg/L 3compartmentss NA 95% Human Human +DTXSID2026527 Css NA 0.1416 mg/L PBTK NA 50% Human Human +DTXSID2026527 Css NA 0.8377 mg/L PBTK NA 95% Human Human +DTXSID2026527 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026527 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026527 Vd NA 0.3744 L/kg 1compartment NA NA Rat Human DTXSID2026527 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026527 TK.Half.Life NA 0.952 hours 1compartment NA NA Rat Human -DTXSID2026527 Css NA 0.3288 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026527 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026527 Css NA 0.1966 mg/L PBTK NA 50% Rat Human -DTXSID2026527 Css NA 0.7566 mg/L PBTK NA 95% Rat Human +DTXSID2026527 TK.Half.Life NA 0.5161 hours 1compartment NA NA Rat Human +DTXSID2026527 Css NA 0.02593 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026527 Css NA 0.1189 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026527 Css NA 0.01692 mg/L PBTK NA 50% Rat Human +DTXSID2026527 Css NA 0.07209 mg/L PBTK NA 95% Rat Human DTXSID2026529 Clint 36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2026529 Fup 0.0264 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2026529 Vd NA 1.484 L/kg 1compartment NA NA Human Human -DTXSID2026529 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026529 TK.Half.Life NA 7.29 hours 1compartment NA NA Human Human -DTXSID2026529 Css NA 0.5636 mg/L 3compartmentss NA 50% Human Human -DTXSID2026529 Css NA 3.948 mg/L 3compartmentss NA 95% Human Human -DTXSID2026529 Css NA 0.3618 mg/L PBTK NA 50% Human Human -DTXSID2026529 Css NA 2.432 mg/L PBTK NA 95% Human Human +DTXSID2026529 Vd NA 2.524 L/kg 1compartment NA NA Human Human +DTXSID2026529 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2026529 TK.Half.Life NA 17.3 hours 1compartment NA NA Human Human +DTXSID2026529 Css NA 0.7706 mg/L 3compartmentss NA 50% Human Human +DTXSID2026529 Css NA 5.071 mg/L 3compartmentss NA 95% Human Human +DTXSID2026529 Css NA 0.5203 mg/L PBTK NA 50% Human Human +DTXSID2026529 Css NA 3.325 mg/L PBTK NA 95% Human Human DTXSID2026529 Clint 36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2026529 Fup 0.0264 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2026529 Vd NA 1.105 L/kg 1compartment NA NA Rat Human +DTXSID2026529 Vd NA 1.884 L/kg 1compartment NA NA Rat Human DTXSID2026529 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026529 TK.Half.Life NA 2.809 hours 1compartment NA NA Rat Human -DTXSID2026529 Css NA 0.3111 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026529 Css NA 1.854 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026529 Css NA 0.1872 mg/L PBTK NA 50% Rat Human -DTXSID2026529 Css NA 1.078 mg/L PBTK NA 95% Rat Human -DTXSID2026573 Clint NA 21.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026573 Fup NA 0.1124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026573 Vd NA 1.334 L/kg 1compartment NA NA Human Human +DTXSID2026529 TK.Half.Life NA 4.316 hours 1compartment NA NA Rat Human +DTXSID2026529 Css NA 0.09921 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026529 Css NA 0.5736 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026529 Css NA 0.06582 mg/L PBTK NA 50% Rat Human +DTXSID2026529 Css NA 0.3729 mg/L PBTK NA 95% Rat Human +DTXSID2026573 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026573 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026573 Vd NA 1.653 L/kg 1compartment NA NA Human Human DTXSID2026573 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026573 TK.Half.Life NA 3.445 hours 1compartment NA NA Human Human -DTXSID2026573 Css NA 0.2754 mg/L 3compartmentss NA 50% Human Human -DTXSID2026573 Css NA 2.085 mg/L 3compartmentss NA 95% Human Human -DTXSID2026573 Css NA 0.1836 mg/L PBTK NA 50% Human Human -DTXSID2026573 Css NA 1.309 mg/L PBTK NA 95% Human Human -DTXSID2026573 Clint NA 21.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026573 Fup NA 0.1124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026573 Vd NA 1.033 L/kg 1compartment NA NA Rat Human +DTXSID2026573 TK.Half.Life NA 7.202 hours 1compartment NA NA Human Human +DTXSID2026573 Css NA 0.4302 mg/L 3compartmentss NA 50% Human Human +DTXSID2026573 Css NA 2.535 mg/L 3compartmentss NA 95% Human Human +DTXSID2026573 Css NA 0.3092 mg/L PBTK NA 50% Human Human +DTXSID2026573 Css NA 1.686 mg/L PBTK NA 95% Human Human +DTXSID2026573 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026573 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026573 Vd NA 1.292 L/kg 1compartment NA NA Rat Human DTXSID2026573 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026573 TK.Half.Life NA 1.395 hours 1compartment NA NA Rat Human -DTXSID2026573 Css NA 0.1536 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026573 Css NA 0.8974 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026573 Css NA 0.09646 mg/L PBTK NA 50% Rat Human -DTXSID2026573 Css NA 0.5261 mg/L PBTK NA 95% Rat Human +DTXSID2026573 TK.Half.Life NA 2.702 hours 1compartment NA NA Rat Human +DTXSID2026573 Css NA 0.05197 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026573 Css NA 0.2129 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026573 Css NA 0.03713 mg/L PBTK NA 50% Rat Human +DTXSID2026573 Css NA 0.1418 mg/L PBTK NA 95% Rat Human DTXSID2026600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2026600 Fup NA 0.6818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026600 Vd NA 0.6488 L/kg 1compartment NA NA Human Human +DTXSID2026600 Vd NA 0.7706 L/kg 1compartment NA NA Human Human DTXSID2026600 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026600 TK.Half.Life NA 6.161 hours 1compartment NA NA Human Human -DTXSID2026600 Css NA 1.114 mg/L 3compartmentss NA 50% Human Human -DTXSID2026600 Css NA 7.731 mg/L 3compartmentss NA 95% Human Human -DTXSID2026600 Css NA 0.891 mg/L PBTK NA 50% Human Human -DTXSID2026600 Css NA 4.885 mg/L PBTK NA 95% Human Human +DTXSID2026600 TK.Half.Life NA 7.359 hours 1compartment NA NA Human Human +DTXSID2026600 Css NA 0.9248 mg/L 3compartmentss NA 50% Human Human +DTXSID2026600 Css NA 6.212 mg/L 3compartmentss NA 95% Human Human +DTXSID2026600 Css NA 0.7659 mg/L PBTK NA 50% Human Human +DTXSID2026600 Css NA 3.961 mg/L PBTK NA 95% Human Human DTXSID2026600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2026600 Fup NA 0.6818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026600 Vd NA 0.6734 L/kg 1compartment NA NA Rat Human +DTXSID2026600 Vd NA 0.7747 L/kg 1compartment NA NA Rat Human DTXSID2026600 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026600 TK.Half.Life NA 2.178 hours 1compartment NA NA Rat Human -DTXSID2026600 Css NA 0.2932 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026600 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026600 Css NA 0.225 mg/L PBTK NA 50% Rat Human -DTXSID2026600 Css NA 1.085 mg/L PBTK NA 95% Rat Human -DTXSID2026602 Clint 2.52 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2026602 Fup 0.144 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2026602 Vd NA 3.13 L/kg 1compartment NA NA Human Human -DTXSID2026602 Days.Css NA 134 Days PBTK NA NA Human Human -DTXSID2026602 TK.Half.Life NA 562.6 hours 1compartment NA NA Human Human -DTXSID2026602 Css NA 22.42 mg/L 3compartmentss NA 50% Human Human -DTXSID2026602 Css NA 140.5 mg/L 3compartmentss NA 95% Human Human -DTXSID2026602 Css NA 15.61 mg/L PBTK NA 50% Human Human -DTXSID2026602 Css NA 94.61 mg/L PBTK NA 95% Human Human -DTXSID2026602 Clint 2.52 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2026602 Fup 0.144 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2026602 Vd NA 2.346 L/kg 1compartment NA NA Rat Human -DTXSID2026602 Days.Css NA 71 Days PBTK NA NA Rat Human -DTXSID2026602 TK.Half.Life NA 70.58 hours 1compartment NA NA Rat Human -DTXSID2026602 Css NA 12.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026602 Css NA 58.28 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026602 Css NA 8.275 mg/L PBTK NA 50% Rat Human -DTXSID2026602 Css NA 37.84 mg/L PBTK NA 95% Rat Human -DTXSID2026606 Clint NA 7.678 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026606 Fup NA 0.2641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026606 Vd NA 2.857 L/kg 1compartment NA NA Human Human +DTXSID2026600 TK.Half.Life NA 2.51 hours 1compartment NA NA Rat Human +DTXSID2026600 Css NA 0.01776 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026600 Css NA 0.1519 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026600 Css NA 0.01416 mg/L PBTK NA 50% Rat Human +DTXSID2026600 Css NA 0.09474 mg/L PBTK NA 95% Rat Human +DTXSID2026606 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026606 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026606 Vd NA 2.191 L/kg 1compartment NA NA Human Human DTXSID2026606 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026606 TK.Half.Life NA 5.563 hours 1compartment NA NA Human Human -DTXSID2026606 Css NA 0.1234 mg/L 3compartmentss NA 50% Human Human -DTXSID2026606 Css NA 0.9101 mg/L 3compartmentss NA 95% Human Human -DTXSID2026606 Css NA 0.135 mg/L PBTK NA 50% Human Human -DTXSID2026606 Css NA 0.8011 mg/L PBTK NA 95% Human Human -DTXSID2026606 Clint NA 7.678 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026606 Fup NA 0.2641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026606 Vd NA 2.862 L/kg 1compartment NA NA Rat Human +DTXSID2026606 TK.Half.Life NA 3.122 hours 1compartment NA NA Human Human +DTXSID2026606 Css NA 0.08306 mg/L 3compartmentss NA 50% Human Human +DTXSID2026606 Css NA 0.6955 mg/L 3compartmentss NA 95% Human Human +DTXSID2026606 Css NA 0.0767 mg/L PBTK NA 50% Human Human +DTXSID2026606 Css NA 0.529 mg/L PBTK NA 95% Human Human +DTXSID2026606 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026606 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026606 Vd NA 2.182 L/kg 1compartment NA NA Rat Human DTXSID2026606 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026606 TK.Half.Life NA 3.324 hours 1compartment NA NA Rat Human -DTXSID2026606 Css NA 0.06142 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026606 Css NA 0.3592 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026606 Css NA 0.06699 mg/L PBTK NA 50% Rat Human -DTXSID2026606 Css NA 0.2876 mg/L PBTK NA 95% Rat Human -DTXSID2026608 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026608 Fup NA 0.6266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026608 Vd NA 0.4831 L/kg 1compartment NA NA Human Human +DTXSID2026606 TK.Half.Life NA 1.802 hours 1compartment NA NA Rat Human +DTXSID2026606 Css NA 0.01037 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026606 Css NA 0.06873 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026606 Css NA 0.009757 mg/L PBTK NA 50% Rat Human +DTXSID2026606 Css NA 0.05352 mg/L PBTK NA 95% Rat Human +DTXSID2026608 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026608 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026608 Vd NA 0.5343 L/kg 1compartment NA NA Human Human DTXSID2026608 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026608 TK.Half.Life NA 4.987 hours 1compartment NA NA Human Human -DTXSID2026608 Css NA 1.26 mg/L 3compartmentss NA 50% Human Human -DTXSID2026608 Css NA 8.335 mg/L 3compartmentss NA 95% Human Human -DTXSID2026608 Css NA 0.953 mg/L PBTK NA 50% Human Human -DTXSID2026608 Css NA 5.11 mg/L PBTK NA 95% Human Human -DTXSID2026608 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026608 Fup NA 0.6266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026608 Vd NA 0.5006 L/kg 1compartment NA NA Rat Human +DTXSID2026608 TK.Half.Life NA 4.495 hours 1compartment NA NA Human Human +DTXSID2026608 Css NA 0.9146 mg/L 3compartmentss NA 50% Human Human +DTXSID2026608 Css NA 5.535 mg/L 3compartmentss NA 95% Human Human +DTXSID2026608 Css NA 0.7091 mg/L PBTK NA 50% Human Human +DTXSID2026608 Css NA 3.481 mg/L PBTK NA 95% Human Human +DTXSID2026608 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026608 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026608 Vd NA 0.5553 L/kg 1compartment NA NA Rat Human DTXSID2026608 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026608 TK.Half.Life NA 1.761 hours 1compartment NA NA Rat Human -DTXSID2026608 Css NA 0.3359 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026608 Css NA 2.028 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026608 Css NA 0.2412 mg/L PBTK NA 50% Rat Human -DTXSID2026608 Css NA 1.17 mg/L PBTK NA 95% Rat Human -DTXSID2026739 Clint NA 311.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026739 Fup NA 0.4484 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026739 Vd NA 0.7713 L/kg 1compartment NA NA Human Human +DTXSID2026608 TK.Half.Life NA 1.592 hours 1compartment NA NA Rat Human +DTXSID2026608 Css NA 0.01738 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026608 Css NA 0.1385 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026608 Css NA 0.01288 mg/L PBTK NA 50% Rat Human +DTXSID2026608 Css NA 0.08772 mg/L PBTK NA 95% Rat Human +DTXSID2026739 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026739 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026739 Vd NA 0.6687 L/kg 1compartment NA NA Human Human DTXSID2026739 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026739 TK.Half.Life NA 0.5523 hours 1compartment NA NA Human Human -DTXSID2026739 Css NA 0.0033 mg/L 3compartmentss NA 50% Human Human -DTXSID2026739 Css NA 0.02981 mg/L 3compartmentss NA 95% Human Human -DTXSID2026739 Css NA 0.00255 mg/L PBTK NA 50% Human Human -DTXSID2026739 Css NA 0.0205 mg/L PBTK NA 95% Human Human -DTXSID2026739 Clint NA 311.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026739 Fup NA 0.4484 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026739 Vd NA 0.7341 L/kg 1compartment NA NA Rat Human +DTXSID2026739 TK.Half.Life NA 0.7219 hours 1compartment NA NA Human Human +DTXSID2026739 Css NA 0.0444 mg/L 3compartmentss NA 50% Human Human +DTXSID2026739 Css NA 0.3825 mg/L 3compartmentss NA 95% Human Human +DTXSID2026739 Css NA 0.03327 mg/L PBTK NA 50% Human Human +DTXSID2026739 Css NA 0.2657 mg/L PBTK NA 95% Human Human +DTXSID2026739 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026739 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026739 Vd NA 0.6529 L/kg 1compartment NA NA Rat Human DTXSID2026739 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026739 TK.Half.Life NA 0.2318 hours 1compartment NA NA Rat Human -DTXSID2026739 Css NA 0.001772 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026739 Css NA 0.01376 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026739 Css NA 0.001325 mg/L PBTK NA 50% Rat Human -DTXSID2026739 Css NA 0.008913 mg/L PBTK NA 95% Rat Human +DTXSID2026739 TK.Half.Life NA 0.3603 hours 1compartment NA NA Rat Human +DTXSID2026739 Css NA 0.005542 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026739 Css NA 0.03691 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026739 Css NA 0.004168 mg/L PBTK NA 50% Rat Human +DTXSID2026739 Css NA 0.0247 mg/L PBTK NA 95% Rat Human DTXSID2026783 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2026783 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026783 Vd NA 0.6393 L/kg 1compartment NA NA Human Human +DTXSID2026783 Vd NA 0.6352 L/kg 1compartment NA NA Human Human DTXSID2026783 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026783 TK.Half.Life NA 4.138 hours 1compartment NA NA Human Human -DTXSID2026783 Css NA 0.8804 mg/L 3compartmentss NA 50% Human Human -DTXSID2026783 Css NA 5.613 mg/L 3compartmentss NA 95% Human Human -DTXSID2026783 Css NA 0.6989 mg/L PBTK NA 50% Human Human -DTXSID2026783 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID2026783 TK.Half.Life NA 4.111 hours 1compartment NA NA Human Human +DTXSID2026783 Css NA 0.7428 mg/L 3compartmentss NA 50% Human Human +DTXSID2026783 Css NA 5.161 mg/L 3compartmentss NA 95% Human Human +DTXSID2026783 Css NA 0.5894 mg/L PBTK NA 50% Human Human +DTXSID2026783 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID2026783 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2026783 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026783 Vd NA 0.6706 L/kg 1compartment NA NA Rat Human +DTXSID2026783 Vd NA 0.667 L/kg 1compartment NA NA Rat Human DTXSID2026783 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026783 TK.Half.Life NA 1.479 hours 1compartment NA NA Rat Human -DTXSID2026783 Css NA 0.2222 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026783 Css NA 1.355 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026783 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID2026783 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID2026783 TK.Half.Life NA 1.471 hours 1compartment NA NA Rat Human +DTXSID2026783 Css NA 0.01368 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026783 Css NA 0.1028 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026783 Css NA 0.0105 mg/L PBTK NA 50% Rat Human +DTXSID2026783 Css NA 0.0655 mg/L PBTK NA 95% Rat Human DTXSID2026789 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2026789 Fup NA 0.7905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2026789 Vd NA 0.7487 L/kg 1compartment NA NA Human Human DTXSID2026789 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2026789 TK.Half.Life NA 6.139 hours 1compartment NA NA Human Human -DTXSID2026789 Css NA 0.9877 mg/L 3compartmentss NA 50% Human Human -DTXSID2026789 Css NA 6.141 mg/L 3compartmentss NA 95% Human Human -DTXSID2026789 Css NA 0.8164 mg/L PBTK NA 50% Human Human -DTXSID2026789 Css NA 3.939 mg/L PBTK NA 95% Human Human +DTXSID2026789 Css NA 0.8448 mg/L 3compartmentss NA 50% Human Human +DTXSID2026789 Css NA 5.651 mg/L 3compartmentss NA 95% Human Human +DTXSID2026789 Css NA 0.6992 mg/L PBTK NA 50% Human Human +DTXSID2026789 Css NA 3.589 mg/L PBTK NA 95% Human Human DTXSID2026789 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2026789 Fup NA 0.7905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2026789 Vd NA 0.7705 L/kg 1compartment NA NA Rat Human DTXSID2026789 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2026789 TK.Half.Life NA 2.15 hours 1compartment NA NA Rat Human -DTXSID2026789 Css NA 0.2538 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026789 Css NA 1.572 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026789 Css NA 0.2034 mg/L PBTK NA 50% Rat Human -DTXSID2026789 Css NA 0.9381 mg/L PBTK NA 95% Rat Human +DTXSID2026789 Css NA 0.01605 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026789 Css NA 0.1199 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026789 Css NA 0.01287 mg/L PBTK NA 50% Rat Human +DTXSID2026789 Css NA 0.07827 mg/L PBTK NA 95% Rat Human +DTXSID2026941 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2026941 Fup NA 0.0541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2026941 Vd NA 0.3596 L/kg 1compartment NA NA Human Human +DTXSID2026941 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID2026941 TK.Half.Life NA 43.43 hours 1compartment NA NA Human Human +DTXSID2026941 Css NA 19.54 mg/L 3compartmentss NA 50% Human Human +DTXSID2026941 Css NA 89.49 mg/L 3compartmentss NA 95% Human Human +DTXSID2026941 Css NA 11.78 mg/L PBTK NA 50% Human Human +DTXSID2026941 Css NA 52.04 mg/L PBTK NA 95% Human Human +DTXSID2026941 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2026941 Fup NA 0.0541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2026941 Vd NA 0.3183 L/kg 1compartment NA NA Rat Human +DTXSID2026941 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2026941 TK.Half.Life NA 13 hours 1compartment NA NA Rat Human +DTXSID2026941 Css NA 1.268 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026941 Css NA 5.015 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026941 Css NA 0.7418 mg/L PBTK NA 50% Rat Human +DTXSID2026941 Css NA 2.839 mg/L PBTK NA 95% Rat Human DTXSID2026943 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2026943 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2026943 Vd NA 0.735 L/kg 1compartment NA NA Human Human DTXSID2026943 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2026943 TK.Half.Life NA 4.757 hours 1compartment NA NA Human Human -DTXSID2026943 Css NA 0.8384 mg/L 3compartmentss NA 50% Human Human -DTXSID2026943 Css NA 5.531 mg/L 3compartmentss NA 95% Human Human -DTXSID2026943 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID2026943 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID2026943 Css NA 0.7066 mg/L 3compartmentss NA 50% Human Human +DTXSID2026943 Css NA 5.058 mg/L 3compartmentss NA 95% Human Human +DTXSID2026943 Css NA 0.5893 mg/L PBTK NA 50% Human Human +DTXSID2026943 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID2026943 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2026943 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2026943 Vd NA 0.7792 L/kg 1compartment NA NA Rat Human DTXSID2026943 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2026943 TK.Half.Life NA 1.718 hours 1compartment NA NA Rat Human -DTXSID2026943 Css NA 0.2106 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026943 Css NA 1.312 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026943 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID2026943 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID2026991 Clint NA 340.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026991 Fup NA 0.6605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026991 Vd NA 1.099 L/kg 1compartment NA NA Human Human -DTXSID2026991 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026991 TK.Half.Life NA 0.673 hours 1compartment NA NA Human Human -DTXSID2026991 Css NA 0.002123 mg/L 3compartmentss NA 50% Human Human -DTXSID2026991 Css NA 0.02406 mg/L 3compartmentss NA 95% Human Human -DTXSID2026991 Css NA 0.001796 mg/L PBTK NA 50% Human Human -DTXSID2026991 Css NA 0.01685 mg/L PBTK NA 95% Human Human -DTXSID2026991 Clint NA 340.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026991 Fup NA 0.6605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026991 Vd NA 1.02 L/kg 1compartment NA NA Rat Human +DTXSID2026943 Css NA 0.01295 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026943 Css NA 0.1002 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026943 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID2026943 Css NA 0.06526 mg/L PBTK NA 95% Rat Human +DTXSID2026991 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026991 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026991 Vd NA 0.9386 L/kg 1compartment NA NA Human Human +DTXSID2026991 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2026991 TK.Half.Life NA 14.01 hours 1compartment NA NA Human Human +DTXSID2026991 Css NA 1.522 mg/L 3compartmentss NA 50% Human Human +DTXSID2026991 Css NA 7.294 mg/L 3compartmentss NA 95% Human Human +DTXSID2026991 Css NA 1.213 mg/L PBTK NA 50% Human Human +DTXSID2026991 Css NA 4.728 mg/L PBTK NA 95% Human Human +DTXSID2026991 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026991 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026991 Vd NA 0.8571 L/kg 1compartment NA NA Rat Human DTXSID2026991 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026991 TK.Half.Life NA 0.2724 hours 1compartment NA NA Rat Human -DTXSID2026991 Css NA 0.001094 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026991 Css NA 0.01152 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026991 Css NA 0.0009154 mg/L PBTK NA 50% Rat Human -DTXSID2026991 Css NA 0.008079 mg/L PBTK NA 95% Rat Human -DTXSID2026997 Clint NA 42.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026997 Fup NA 0.6317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2026997 Vd NA 1.671 L/kg 1compartment NA NA Human Human +DTXSID2026991 TK.Half.Life NA 4.211 hours 1compartment NA NA Rat Human +DTXSID2026991 Css NA 0.09679 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026991 Css NA 0.3992 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026991 Css NA 0.07653 mg/L PBTK NA 50% Rat Human +DTXSID2026991 Css NA 0.2516 mg/L PBTK NA 95% Rat Human +DTXSID2026997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026997 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2026997 Vd NA 1.122 L/kg 1compartment NA NA Human Human DTXSID2026997 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2026997 TK.Half.Life NA 1.253 hours 1compartment NA NA Human Human -DTXSID2026997 Css NA 0.0187 mg/L 3compartmentss NA 50% Human Human -DTXSID2026997 Css NA 0.2081 mg/L 3compartmentss NA 95% Human Human -DTXSID2026997 Css NA 0.01633 mg/L PBTK NA 50% Human Human -DTXSID2026997 Css NA 0.1498 mg/L PBTK NA 95% Human Human -DTXSID2026997 Clint NA 42.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026997 Fup NA 0.6317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2026997 Vd NA 1.419 L/kg 1compartment NA NA Rat Human +DTXSID2026997 TK.Half.Life NA 1.486 hours 1compartment NA NA Human Human +DTXSID2026997 Css NA 0.0703 mg/L 3compartmentss NA 50% Human Human +DTXSID2026997 Css NA 0.5364 mg/L 3compartmentss NA 95% Human Human +DTXSID2026997 Css NA 0.05214 mg/L PBTK NA 50% Human Human +DTXSID2026997 Css NA 0.371 mg/L PBTK NA 95% Human Human +DTXSID2026997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026997 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2026997 Vd NA 0.9449 L/kg 1compartment NA NA Rat Human DTXSID2026997 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2026997 TK.Half.Life NA 0.4837 hours 1compartment NA NA Rat Human -DTXSID2026997 Css NA 0.009754 mg/L 3compartmentss NA 50% Rat Human -DTXSID2026997 Css NA 0.08996 mg/L 3compartmentss NA 95% Rat Human -DTXSID2026997 Css NA 0.008437 mg/L PBTK NA 50% Rat Human -DTXSID2026997 Css NA 0.06355 mg/L PBTK NA 95% Rat Human +DTXSID2026997 TK.Half.Life NA 0.6424 hours 1compartment NA NA Rat Human +DTXSID2026997 Css NA 0.00876 mg/L 3compartmentss NA 50% Rat Human +DTXSID2026997 Css NA 0.04949 mg/L 3compartmentss NA 95% Rat Human +DTXSID2026997 Css NA 0.006509 mg/L PBTK NA 50% Rat Human +DTXSID2026997 Css NA 0.03307 mg/L PBTK NA 95% Rat Human DTXSID2027044 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2027044 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027044 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID2027044 Vd NA 0.35 L/kg 1compartment NA NA Human Human DTXSID2027044 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027044 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID2027044 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID2027044 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID2027044 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID2027044 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID2027044 TK.Half.Life NA 7.009 hours 1compartment NA NA Human Human +DTXSID2027044 Css NA 2.036 mg/L 3compartmentss NA 50% Human Human +DTXSID2027044 Css NA 8.567 mg/L 3compartmentss NA 95% Human Human +DTXSID2027044 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID2027044 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID2027044 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2027044 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027044 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID2027044 Vd NA 0.364 L/kg 1compartment NA NA Rat Human DTXSID2027044 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027044 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID2027044 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027044 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027044 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID2027044 Css NA 1.313 mg/L PBTK NA 95% Rat Human -DTXSID2027048 Clint NA 0.1202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027048 Fup NA 0.2864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027048 Vd NA 0.4706 L/kg 1compartment NA NA Human Human +DTXSID2027044 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human +DTXSID2027044 Css NA 0.03816 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027044 Css NA 0.226 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027044 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID2027044 Css NA 0.1369 mg/L PBTK NA 95% Rat Human +DTXSID2027048 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027048 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027048 Vd NA 0.3561 L/kg 1compartment NA NA Human Human DTXSID2027048 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027048 TK.Half.Life NA 8.828 hours 1compartment NA NA Human Human -DTXSID2027048 Css NA 2.149 mg/L 3compartmentss NA 50% Human Human -DTXSID2027048 Css NA 8.649 mg/L 3compartmentss NA 95% Human Human -DTXSID2027048 Css NA 1.52 mg/L PBTK NA 50% Human Human -DTXSID2027048 Css NA 5.399 mg/L PBTK NA 95% Human Human -DTXSID2027048 Clint NA 0.1202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027048 Fup NA 0.2864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027048 Vd NA 0.4788 L/kg 1compartment NA NA Rat Human +DTXSID2027048 TK.Half.Life NA 7.891 hours 1compartment NA NA Human Human +DTXSID2027048 Css NA 2.286 mg/L 3compartmentss NA 50% Human Human +DTXSID2027048 Css NA 8.957 mg/L 3compartmentss NA 95% Human Human +DTXSID2027048 Css NA 1.532 mg/L PBTK NA 50% Human Human +DTXSID2027048 Css NA 5.508 mg/L PBTK NA 95% Human Human +DTXSID2027048 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027048 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027048 Vd NA 0.3783 L/kg 1compartment NA NA Rat Human DTXSID2027048 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027048 TK.Half.Life NA 3.353 hours 1compartment NA NA Rat Human -DTXSID2027048 Css NA 0.662 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027048 Css NA 2.203 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027048 Css NA 0.4422 mg/L PBTK NA 50% Rat Human -DTXSID2027048 Css NA 1.287 mg/L PBTK NA 95% Rat Human -DTXSID2027092 Clint NA 1.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027092 Fup NA 0.9445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027092 Vd NA 0.9788 L/kg 1compartment NA NA Human Human +DTXSID2027048 TK.Half.Life NA 2.856 hours 1compartment NA NA Rat Human +DTXSID2027048 Css NA 0.0417 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027048 Css NA 0.2425 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027048 Css NA 0.02696 mg/L PBTK NA 50% Rat Human +DTXSID2027048 Css NA 0.1466 mg/L PBTK NA 95% Rat Human +DTXSID2027092 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027092 Fup 0.712 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027092 Vd NA 0.8235 L/kg 1compartment NA NA Human Human DTXSID2027092 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027092 TK.Half.Life NA 2.314 hours 1compartment NA NA Human Human -DTXSID2027092 Css NA 0.2512 mg/L 3compartmentss NA 50% Human Human -DTXSID2027092 Css NA 1.137 mg/L 3compartmentss NA 95% Human Human -DTXSID2027092 Css NA 0.2182 mg/L PBTK NA 50% Human Human -DTXSID2027092 Css NA 0.8411 mg/L PBTK NA 95% Human Human -DTXSID2027092 Clint NA 1.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027092 Fup NA 0.9445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027092 Vd NA 0.9787 L/kg 1compartment NA NA Rat Human +DTXSID2027092 TK.Half.Life NA 7.552 hours 1compartment NA NA Human Human +DTXSID2027092 Css NA 0.8862 mg/L 3compartmentss NA 50% Human Human +DTXSID2027092 Css NA 6.074 mg/L 3compartmentss NA 95% Human Human +DTXSID2027092 Css NA 0.7415 mg/L PBTK NA 50% Human Human +DTXSID2027092 Css NA 3.896 mg/L PBTK NA 95% Human Human +DTXSID2027092 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027092 Fup 0.712 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027092 Vd NA 0.8218 L/kg 1compartment NA NA Rat Human DTXSID2027092 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027092 TK.Half.Life NA 1.147 hours 1compartment NA NA Rat Human -DTXSID2027092 Css NA 0.09968 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027092 Css NA 0.3616 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027092 Css NA 0.08663 mg/L PBTK NA 50% Rat Human -DTXSID2027092 Css NA 0.2449 mg/L PBTK NA 95% Rat Human -DTXSID2027094 Clint NA 12.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027094 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027094 Vd NA 4.119 L/kg 1compartment NA NA Human Human -DTXSID2027094 Days.Css NA 41 Days PBTK NA NA Human Human -DTXSID2027094 TK.Half.Life NA 208.7 hours 1compartment NA NA Human Human -DTXSID2027094 Css NA 5.505 mg/L 3compartmentss NA 50% Human Human -DTXSID2027094 Css NA 30.79 mg/L 3compartmentss NA 95% Human Human -DTXSID2027094 Css NA 4.139 mg/L PBTK NA 50% Human Human -DTXSID2027094 Css NA 22.96 mg/L PBTK NA 95% Human Human -DTXSID2027094 Clint NA 12.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027094 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027094 Vd NA 3.121 L/kg 1compartment NA NA Rat Human -DTXSID2027094 Days.Css NA 23 Days PBTK NA NA Rat Human -DTXSID2027094 TK.Half.Life NA 27.96 hours 1compartment NA NA Rat Human -DTXSID2027094 Css NA 3.083 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027094 Css NA 12.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027094 Css NA 2.234 mg/L PBTK NA 50% Rat Human -DTXSID2027094 Css NA 9.531 mg/L PBTK NA 95% Rat Human -DTXSID2027096 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027096 Fup NA 0.6879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027096 Vd NA 1.09 L/kg 1compartment NA NA Human Human +DTXSID2027092 TK.Half.Life NA 2.551 hours 1compartment NA NA Rat Human +DTXSID2027092 Css NA 0.01693 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027092 Css NA 0.1399 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027092 Css NA 0.01367 mg/L PBTK NA 50% Rat Human +DTXSID2027092 Css NA 0.09029 mg/L PBTK NA 95% Rat Human +DTXSID2027094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027094 Fup 0.0108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027094 Vd NA 24 L/kg 1compartment NA NA Human Human +DTXSID2027094 Days.Css NA 168 Days PBTK NA NA Human Human +DTXSID2027094 TK.Half.Life NA 713.3 hours 1compartment NA NA Human Human +DTXSID2027094 Css NA 0.5145 mg/L 3compartmentss NA 50% Human Human +DTXSID2027094 Css NA 3.594 mg/L 3compartmentss NA 95% Human Human +DTXSID2027094 Css NA 1.31 mg/L PBTK NA 50% Human Human +DTXSID2027094 Css NA 8.31 mg/L PBTK NA 95% Human Human +DTXSID2027094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027094 Fup 0.0108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027094 Vd NA 19.64 L/kg 1compartment NA NA Rat Human +DTXSID2027094 Days.Css NA 102 Days PBTK NA NA Rat Human +DTXSID2027094 TK.Half.Life NA 102.6 hours 1compartment NA NA Rat Human +DTXSID2027094 Css NA 0.005224 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027094 Css NA 0.03058 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027094 Css NA 0.01387 mg/L PBTK NA 50% Rat Human +DTXSID2027094 Css NA 0.07916 mg/L PBTK NA 95% Rat Human +DTXSID2027096 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027096 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027096 Vd NA 1.312 L/kg 1compartment NA NA Human Human DTXSID2027096 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2027096 TK.Half.Life NA 10.75 hours 1compartment NA NA Human Human -DTXSID2027096 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human -DTXSID2027096 Css NA 7.035 mg/L 3compartmentss NA 95% Human Human -DTXSID2027096 Css NA 0.9196 mg/L PBTK NA 50% Human Human -DTXSID2027096 Css NA 4.558 mg/L PBTK NA 95% Human Human -DTXSID2027096 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027096 Fup NA 0.6879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027096 Vd NA 1.019 L/kg 1compartment NA NA Rat Human +DTXSID2027096 TK.Half.Life NA 12.89 hours 1compartment NA NA Human Human +DTXSID2027096 Css NA 0.8742 mg/L 3compartmentss NA 50% Human Human +DTXSID2027096 Css NA 5.834 mg/L 3compartmentss NA 95% Human Human +DTXSID2027096 Css NA 0.7829 mg/L PBTK NA 50% Human Human +DTXSID2027096 Css NA 3.879 mg/L PBTK NA 95% Human Human +DTXSID2027096 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027096 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027096 Vd NA 1.187 L/kg 1compartment NA NA Rat Human DTXSID2027096 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027096 TK.Half.Life NA 3.304 hours 1compartment NA NA Rat Human -DTXSID2027096 Css NA 0.2763 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027096 Css NA 1.825 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027096 Css NA 0.2321 mg/L PBTK NA 50% Rat Human -DTXSID2027096 Css NA 1.101 mg/L PBTK NA 95% Rat Human +DTXSID2027096 TK.Half.Life NA 3.705 hours 1compartment NA NA Rat Human +DTXSID2027096 Css NA 0.01625 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027096 Css NA 0.1407 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027096 Css NA 0.01414 mg/L PBTK NA 50% Rat Human +DTXSID2027096 Css NA 0.09362 mg/L PBTK NA 95% Rat Human DTXSID2027098 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2027098 Fup NA 0.7682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027098 Vd NA 0.6126 L/kg 1compartment NA NA Human Human +DTXSID2027098 Vd NA 0.6285 L/kg 1compartment NA NA Human Human DTXSID2027098 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027098 TK.Half.Life NA 5.161 hours 1compartment NA NA Human Human -DTXSID2027098 Css NA 1.057 mg/L 3compartmentss NA 50% Human Human -DTXSID2027098 Css NA 6.461 mg/L 3compartmentss NA 95% Human Human -DTXSID2027098 Css NA 0.8382 mg/L PBTK NA 50% Human Human -DTXSID2027098 Css NA 4.109 mg/L PBTK NA 95% Human Human +DTXSID2027098 TK.Half.Life NA 5.295 hours 1compartment NA NA Human Human +DTXSID2027098 Css NA 0.8896 mg/L 3compartmentss NA 50% Human Human +DTXSID2027098 Css NA 5.633 mg/L 3compartmentss NA 95% Human Human +DTXSID2027098 Css NA 0.712 mg/L PBTK NA 50% Human Human +DTXSID2027098 Css NA 3.547 mg/L PBTK NA 95% Human Human DTXSID2027098 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2027098 Fup NA 0.7682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027098 Vd NA 0.652 L/kg 1compartment NA NA Rat Human +DTXSID2027098 Vd NA 0.666 L/kg 1compartment NA NA Rat Human DTXSID2027098 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027098 TK.Half.Life NA 1.871 hours 1compartment NA NA Rat Human -DTXSID2027098 Css NA 0.2713 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027098 Css NA 1.674 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027098 Css NA 0.2075 mg/L PBTK NA 50% Rat Human -DTXSID2027098 Css NA 0.9833 mg/L PBTK NA 95% Rat Human -DTXSID2027175 Clint NA 3.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027175 Fup NA 0.4061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027175 Vd NA 2.113 L/kg 1compartment NA NA Human Human +DTXSID2027098 TK.Half.Life NA 1.912 hours 1compartment NA NA Rat Human +DTXSID2027098 Css NA 0.01659 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027098 Css NA 0.131 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027098 Css NA 0.01289 mg/L PBTK NA 50% Rat Human +DTXSID2027098 Css NA 0.08214 mg/L PBTK NA 95% Rat Human +DTXSID2027175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027175 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027175 Vd NA 2.24 L/kg 1compartment NA NA Human Human DTXSID2027175 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027175 TK.Half.Life NA 9.803 hours 1compartment NA NA Human Human -DTXSID2027175 Css NA 0.4618 mg/L 3compartmentss NA 50% Human Human -DTXSID2027175 Css NA 2.204 mg/L 3compartmentss NA 95% Human Human -DTXSID2027175 Css NA 0.368 mg/L PBTK NA 50% Human Human -DTXSID2027175 Css NA 1.579 mg/L PBTK NA 95% Human Human -DTXSID2027175 Clint NA 3.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027175 Fup NA 0.4061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027175 Vd NA 1.674 L/kg 1compartment NA NA Rat Human +DTXSID2027175 TK.Half.Life NA 7.763 hours 1compartment NA NA Human Human +DTXSID2027175 Css NA 0.3718 mg/L 3compartmentss NA 50% Human Human +DTXSID2027175 Css NA 2.566 mg/L 3compartmentss NA 95% Human Human +DTXSID2027175 Css NA 0.2552 mg/L PBTK NA 50% Human Human +DTXSID2027175 Css NA 1.683 mg/L PBTK NA 95% Human Human +DTXSID2027175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027175 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027175 Vd NA 1.695 L/kg 1compartment NA NA Rat Human DTXSID2027175 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027175 TK.Half.Life NA 3.092 hours 1compartment NA NA Rat Human -DTXSID2027175 Css NA 0.2169 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027175 Css NA 0.8064 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027175 Css NA 0.1685 mg/L PBTK NA 50% Rat Human -DTXSID2027175 Css NA 0.5322 mg/L PBTK NA 95% Rat Human -DTXSID2027204 Clint NA 1.891 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027204 Fup NA 0.7459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027204 Vd NA 1.135 L/kg 1compartment NA NA Human Human -DTXSID2027204 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027204 TK.Half.Life NA 2.842 hours 1compartment NA NA Human Human -DTXSID2027204 Css NA 0.2488 mg/L 3compartmentss NA 50% Human Human -DTXSID2027204 Css NA 1.739 mg/L 3compartmentss NA 95% Human Human -DTXSID2027204 Css NA 0.2171 mg/L PBTK NA 50% Human Human -DTXSID2027204 Css NA 1.191 mg/L PBTK NA 95% Human Human -DTXSID2027204 Clint NA 1.891 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027204 Fup NA 0.7459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027204 Vd NA 1.073 L/kg 1compartment NA NA Rat Human -DTXSID2027204 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027204 TK.Half.Life NA 1.361 hours 1compartment NA NA Rat Human -DTXSID2027204 Css NA 0.1045 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027204 Css NA 0.7069 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027204 Css NA 0.08958 mg/L PBTK NA 50% Rat Human -DTXSID2027204 Css NA 0.435 mg/L PBTK NA 95% Rat Human -DTXSID2027206 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027206 Fup NA 0.8402 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027206 Vd NA 1.17 L/kg 1compartment NA NA Human Human +DTXSID2027175 TK.Half.Life NA 2.348 hours 1compartment NA NA Rat Human +DTXSID2027175 Css NA 0.04784 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027175 Css NA 0.2634 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027175 Css NA 0.03231 mg/L PBTK NA 50% Rat Human +DTXSID2027175 Css NA 0.1711 mg/L PBTK NA 95% Rat Human +DTXSID2027206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027206 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027206 Vd NA 1.08 L/kg 1compartment NA NA Human Human DTXSID2027206 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027206 TK.Half.Life NA 9.437 hours 1compartment NA NA Human Human -DTXSID2027206 Css NA 0.9044 mg/L 3compartmentss NA 50% Human Human -DTXSID2027206 Css NA 5.565 mg/L 3compartmentss NA 95% Human Human -DTXSID2027206 Css NA 0.8104 mg/L PBTK NA 50% Human Human -DTXSID2027206 Css NA 3.671 mg/L PBTK NA 95% Human Human -DTXSID2027206 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027206 Fup NA 0.8402 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027206 Vd NA 1.109 L/kg 1compartment NA NA Rat Human +DTXSID2027206 TK.Half.Life NA 0.8637 hours 1compartment NA NA Human Human +DTXSID2027206 Css NA 0.02146 mg/L 3compartmentss NA 50% Human Human +DTXSID2027206 Css NA 0.2626 mg/L 3compartmentss NA 95% Human Human +DTXSID2027206 Css NA 0.01833 mg/L PBTK NA 50% Human Human +DTXSID2027206 Css NA 0.1868 mg/L PBTK NA 95% Human Human +DTXSID2027206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027206 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027206 Vd NA 1.019 L/kg 1compartment NA NA Rat Human DTXSID2027206 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027206 TK.Half.Life NA 2.943 hours 1compartment NA NA Rat Human -DTXSID2027206 Css NA 0.2308 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027206 Css NA 1.424 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027206 Css NA 0.2021 mg/L PBTK NA 50% Rat Human -DTXSID2027206 Css NA 0.879 mg/L PBTK NA 95% Rat Human -DTXSID2027333 Clint NA 208.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027333 Fup NA 0.4828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027333 Vd NA 4.865 L/kg 1compartment NA NA Human Human -DTXSID2027333 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027333 TK.Half.Life NA 1.731 hours 1compartment NA NA Human Human -DTXSID2027333 Css NA 0.001892 mg/L 3compartmentss NA 50% Human Human -DTXSID2027333 Css NA 0.02311 mg/L 3compartmentss NA 95% Human Human -DTXSID2027333 Css NA 0.002977 mg/L PBTK NA 50% Human Human -DTXSID2027333 Css NA 0.02394 mg/L PBTK NA 95% Human Human -DTXSID2027333 Clint NA 208.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027333 Fup NA 0.4828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027333 Vd NA 4.938 L/kg 1compartment NA NA Rat Human -DTXSID2027333 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027333 TK.Half.Life NA 0.8022 hours 1compartment NA NA Rat Human -DTXSID2027333 Css NA 0.0009808 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027333 Css NA 0.01032 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027333 Css NA 0.001583 mg/L PBTK NA 50% Rat Human -DTXSID2027333 Css NA 0.01078 mg/L PBTK NA 95% Rat Human -DTXSID2027381 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027381 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027381 Vd NA 41.1 L/kg 1compartment NA NA Human Human -DTXSID2027381 Days.Css NA 11150 Days PBTK NA NA Human Human -DTXSID2027381 TK.Half.Life NA 1969000 hours 1compartment NA NA Human Human -DTXSID2027381 Css NA 828.4 mg/L 3compartmentss NA 50% Human Human -DTXSID2027381 Css NA 2137 mg/L 3compartmentss NA 95% Human Human -DTXSID2027381 Css NA 3700 mg/L PBTK NA 50% Human Human -DTXSID2027381 Css NA 7983 mg/L PBTK NA 95% Human Human -DTXSID2027381 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027381 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027381 Vd NA 34.38 L/kg 1compartment NA NA Rat Human -DTXSID2027381 Days.Css NA 13780 Days PBTK NA NA Rat Human -DTXSID2027381 TK.Half.Life NA 139400 hours 1compartment NA NA Rat Human -DTXSID2027381 Css NA 206.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027381 Css NA 354.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027381 Css NA 992 mg/L PBTK NA 50% Rat Human -DTXSID2027381 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID2027412 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027412 Fup NA 0.4552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027412 Vd NA 0.7897 L/kg 1compartment NA NA Human Human +DTXSID2027206 TK.Half.Life NA 0.3965 hours 1compartment NA NA Rat Human +DTXSID2027206 Css NA 0.0007572 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027206 Css NA 0.01038 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027206 Css NA 0.0006445 mg/L PBTK NA 50% Rat Human +DTXSID2027206 Css NA 0.007113 mg/L PBTK NA 95% Rat Human +DTXSID2027333 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027333 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027333 Vd NA 3.574 L/kg 1compartment NA NA Human Human +DTXSID2027333 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID2027333 TK.Half.Life NA 88.13 hours 1compartment NA NA Human Human +DTXSID2027333 Css NA 1.551 mg/L 3compartmentss NA 50% Human Human +DTXSID2027333 Css NA 7.968 mg/L 3compartmentss NA 95% Human Human +DTXSID2027333 Css NA 1.935 mg/L PBTK NA 50% Human Human +DTXSID2027333 Css NA 6.725 mg/L PBTK NA 95% Human Human +DTXSID2027333 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027333 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027333 Vd NA 3.602 L/kg 1compartment NA NA Rat Human +DTXSID2027333 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID2027333 TK.Half.Life NA 29.86 hours 1compartment NA NA Rat Human +DTXSID2027333 Css NA 0.096 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027333 Css NA 0.4204 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027333 Css NA 0.1239 mg/L PBTK NA 50% Rat Human +DTXSID2027333 Css NA 0.3444 mg/L PBTK NA 95% Rat Human +DTXSID2027412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027412 Fup 0.639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027412 Vd NA 1.085 L/kg 1compartment NA NA Human Human DTXSID2027412 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2027412 TK.Half.Life NA 11.27 hours 1compartment NA NA Human Human -DTXSID2027412 Css NA 1.54 mg/L 3compartmentss NA 50% Human Human -DTXSID2027412 Css NA 7.219 mg/L 3compartmentss NA 95% Human Human -DTXSID2027412 Css NA 1.198 mg/L PBTK NA 50% Human Human -DTXSID2027412 Css NA 4.693 mg/L PBTK NA 95% Human Human -DTXSID2027412 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027412 Fup NA 0.4552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027412 Vd NA 0.7909 L/kg 1compartment NA NA Rat Human +DTXSID2027412 TK.Half.Life NA 11.12 hours 1compartment NA NA Human Human +DTXSID2027412 Css NA 1.074 mg/L 3compartmentss NA 50% Human Human +DTXSID2027412 Css NA 7.466 mg/L 3compartmentss NA 95% Human Human +DTXSID2027412 Css NA 0.9175 mg/L PBTK NA 50% Human Human +DTXSID2027412 Css NA 4.841 mg/L PBTK NA 95% Human Human +DTXSID2027412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027412 Fup 0.639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027412 Vd NA 1.076 L/kg 1compartment NA NA Rat Human DTXSID2027412 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027412 TK.Half.Life NA 3.836 hours 1compartment NA NA Rat Human -DTXSID2027412 Css NA 0.4172 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027412 Css NA 1.722 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027412 Css NA 0.3116 mg/L PBTK NA 50% Rat Human -DTXSID2027412 Css NA 1.037 mg/L PBTK NA 95% Rat Human +DTXSID2027412 TK.Half.Life NA 3.723 hours 1compartment NA NA Rat Human +DTXSID2027412 Css NA 0.06391 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027412 Css NA 0.4091 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027412 Css NA 0.05516 mg/L PBTK NA 50% Rat Human +DTXSID2027412 Css NA 0.255 mg/L PBTK NA 95% Rat Human DTXSID2027414 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2027414 Fup 0.364 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2027414 Vd NA 1.584 L/kg 1compartment NA NA Human Human DTXSID2027414 Days.Css NA 5 Days PBTK NA NA Human Human DTXSID2027414 TK.Half.Life NA 36.91 hours 1compartment NA NA Human Human -DTXSID2027414 Css NA 2.368 mg/L 3compartmentss NA 50% Human Human -DTXSID2027414 Css NA 6.958 mg/L 3compartmentss NA 95% Human Human -DTXSID2027414 Css NA 1.883 mg/L PBTK NA 50% Human Human -DTXSID2027414 Css NA 4.883 mg/L PBTK NA 95% Human Human +DTXSID2027414 Css NA 2.3 mg/L 3compartmentss NA 50% Human Human +DTXSID2027414 Css NA 6.794 mg/L 3compartmentss NA 95% Human Human +DTXSID2027414 Css NA 1.816 mg/L PBTK NA 50% Human Human +DTXSID2027414 Css NA 4.798 mg/L PBTK NA 95% Human Human DTXSID2027414 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2027414 Fup 0.364 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2027414 Vd NA 1.29 L/kg 1compartment NA NA Rat Human DTXSID2027414 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID2027414 TK.Half.Life NA 8.396 hours 1compartment NA NA Rat Human -DTXSID2027414 Css NA 0.6365 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027414 Css NA 1.529 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027414 Css NA 0.4876 mg/L PBTK NA 50% Rat Human -DTXSID2027414 Css NA 0.995 mg/L PBTK NA 95% Rat Human -DTXSID2027418 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027418 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027418 Vd NA 1.012 L/kg 1compartment NA NA Human Human +DTXSID2027414 Css NA 0.1447 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027414 Css NA 0.3448 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027414 Css NA 0.1147 mg/L PBTK NA 50% Rat Human +DTXSID2027414 Css NA 0.2326 mg/L PBTK NA 95% Rat Human +DTXSID2027418 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027418 Fup 0.491 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027418 Vd NA 0.6593 L/kg 1compartment NA NA Human Human DTXSID2027418 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027418 TK.Half.Life NA 6.633 hours 1compartment NA NA Human Human -DTXSID2027418 Css NA 0.7764 mg/L 3compartmentss NA 50% Human Human -DTXSID2027418 Css NA 5.656 mg/L 3compartmentss NA 95% Human Human -DTXSID2027418 Css NA 0.6961 mg/L PBTK NA 50% Human Human -DTXSID2027418 Css NA 3.769 mg/L PBTK NA 95% Human Human -DTXSID2027418 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027418 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027418 Vd NA 1.012 L/kg 1compartment NA NA Rat Human +DTXSID2027418 TK.Half.Life NA 8.741 hours 1compartment NA NA Human Human +DTXSID2027418 Css NA 1.236 mg/L 3compartmentss NA 50% Human Human +DTXSID2027418 Css NA 6.387 mg/L 3compartmentss NA 95% Human Human +DTXSID2027418 Css NA 0.9624 mg/L PBTK NA 50% Human Human +DTXSID2027418 Css NA 4.074 mg/L PBTK NA 95% Human Human +DTXSID2027418 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027418 Fup 0.491 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027418 Vd NA 0.6565 L/kg 1compartment NA NA Rat Human DTXSID2027418 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027418 TK.Half.Life NA 2.238 hours 1compartment NA NA Rat Human -DTXSID2027418 Css NA 0.1968 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027418 Css NA 1.241 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027418 Css NA 0.173 mg/L PBTK NA 50% Rat Human -DTXSID2027418 Css NA 0.7653 mg/L PBTK NA 95% Rat Human -DTXSID2027462 Clint NA 0.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027462 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027462 Vd NA 0.3401 L/kg 1compartment NA NA Human Human -DTXSID2027462 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2027462 TK.Half.Life NA 29.99 hours 1compartment NA NA Human Human -DTXSID2027462 Css NA 15.64 mg/L 3compartmentss NA 50% Human Human -DTXSID2027462 Css NA 74.8 mg/L 3compartmentss NA 95% Human Human -DTXSID2027462 Css NA 9.401 mg/L PBTK NA 50% Human Human -DTXSID2027462 Css NA 43.05 mg/L PBTK NA 95% Human Human -DTXSID2027462 Clint NA 0.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027462 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027462 Vd NA 0.2931 L/kg 1compartment NA NA Rat Human -DTXSID2027462 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2027462 TK.Half.Life NA 11.89 hours 1compartment NA NA Rat Human -DTXSID2027462 Css NA 6.076 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027462 Css NA 25.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027462 Css NA 3.407 mg/L PBTK NA 50% Rat Human -DTXSID2027462 Css NA 13.73 mg/L PBTK NA 95% Rat Human -DTXSID2027466 Clint NA 4.881 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027466 Fup NA 0.3121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027466 Vd NA 1.187 L/kg 1compartment NA NA Human Human -DTXSID2027466 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027466 TK.Half.Life NA 3.639 hours 1compartment NA NA Human Human -DTXSID2027466 Css NA 0.2866 mg/L 3compartmentss NA 50% Human Human -DTXSID2027466 Css NA 1.698 mg/L 3compartmentss NA 95% Human Human -DTXSID2027466 Css NA 0.2168 mg/L PBTK NA 50% Human Human -DTXSID2027466 Css NA 1.164 mg/L PBTK NA 95% Human Human -DTXSID2027466 Clint NA 4.881 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027466 Fup NA 0.3121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027466 Vd NA 0.9953 L/kg 1compartment NA NA Rat Human +DTXSID2027418 TK.Half.Life NA 2.953 hours 1compartment NA NA Rat Human +DTXSID2027418 Css NA 0.02312 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027418 Css NA 0.1635 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027418 Css NA 0.01715 mg/L PBTK NA 50% Rat Human +DTXSID2027418 Css NA 0.1045 mg/L PBTK NA 95% Rat Human +DTXSID20274180 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20274180 Fup 0.92 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human +DTXSID20274180 Vd NA 0.6877 L/kg 1compartment NA NA Human Human +DTXSID20274180 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20274180 TK.Half.Life NA 4.84 hours 1compartment NA NA Human Human +DTXSID20274180 Css NA 0.599 mg/L 3compartmentss NA 50% Human Human +DTXSID20274180 Css NA 2.811 mg/L 3compartmentss NA 95% Human Human +DTXSID20274180 Css NA 0.4174 mg/L PBTK NA 50% Human Human +DTXSID20274180 Css NA 1.959 mg/L PBTK NA 95% Human Human +DTXSID20274180 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20274180 Fup 0.92 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human +DTXSID20274180 Vd NA 0.718 L/kg 1compartment NA NA Rat Human +DTXSID20274180 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20274180 TK.Half.Life NA 1.721 hours 1compartment NA NA Rat Human +DTXSID20274180 Css NA 0.002955 mg/L 3compartmentss NA 50% Rat Human +DTXSID20274180 Css NA 0.0149 mg/L 3compartmentss NA 95% Rat Human +DTXSID20274180 Css NA 0.002064 mg/L PBTK NA 50% Rat Human +DTXSID20274180 Css NA 0.01043 mg/L PBTK NA 95% Rat Human +DTXSID2027462 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027462 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027462 Vd NA 0.6936 L/kg 1compartment NA NA Human Human +DTXSID2027462 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2027462 TK.Half.Life NA 1.334 hours 1compartment NA NA Human Human +DTXSID2027462 Css NA 0.1586 mg/L 3compartmentss NA 50% Human Human +DTXSID2027462 Css NA 1.299 mg/L 3compartmentss NA 95% Human Human +DTXSID2027462 Css NA 0.1051 mg/L PBTK NA 50% Human Human +DTXSID2027462 Css NA 0.816 mg/L PBTK NA 95% Human Human +DTXSID2027462 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027462 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027462 Vd NA 0.606 L/kg 1compartment NA NA Rat Human +DTXSID2027462 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2027462 TK.Half.Life NA 0.6533 hours 1compartment NA NA Rat Human +DTXSID2027462 Css NA 0.02062 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027462 Css NA 0.1264 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027462 Css NA 0.01336 mg/L PBTK NA 50% Rat Human +DTXSID2027462 Css NA 0.0768 mg/L PBTK NA 95% Rat Human +DTXSID2027466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027466 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027466 Vd NA 1.089 L/kg 1compartment NA NA Human Human +DTXSID2027466 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2027466 TK.Half.Life NA 15.86 hours 1compartment NA NA Human Human +DTXSID2027466 Css NA 1.471 mg/L 3compartmentss NA 50% Human Human +DTXSID2027466 Css NA 6.947 mg/L 3compartmentss NA 95% Human Human +DTXSID2027466 Css NA 1.2 mg/L PBTK NA 50% Human Human +DTXSID2027466 Css NA 4.67 mg/L PBTK NA 95% Human Human +DTXSID2027466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027466 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027466 Vd NA 0.9713 L/kg 1compartment NA NA Rat Human DTXSID2027466 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027466 TK.Half.Life NA 1.617 hours 1compartment NA NA Rat Human -DTXSID2027466 Css NA 0.1414 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027466 Css NA 0.6277 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027466 Css NA 0.1028 mg/L PBTK NA 50% Rat Human -DTXSID2027466 Css NA 0.398 mg/L PBTK NA 95% Rat Human -DTXSID2027543 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027543 Fup NA 0.9315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027543 Vd NA 0.9482 L/kg 1compartment NA NA Human Human +DTXSID2027466 TK.Half.Life NA 4.554 hours 1compartment NA NA Rat Human +DTXSID2027466 Css NA 0.09246 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027466 Css NA 0.3903 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027466 Css NA 0.07508 mg/L PBTK NA 50% Rat Human +DTXSID2027466 Css NA 0.2478 mg/L PBTK NA 95% Rat Human +DTXSID2027543 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027543 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027543 Vd NA 0.6308 L/kg 1compartment NA NA Human Human DTXSID2027543 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027543 TK.Half.Life NA 6.614 hours 1compartment NA NA Human Human -DTXSID2027543 Css NA 0.833 mg/L 3compartmentss NA 50% Human Human -DTXSID2027543 Css NA 3.1 mg/L 3compartmentss NA 95% Human Human -DTXSID2027543 Css NA 0.7241 mg/L PBTK NA 50% Human Human -DTXSID2027543 Css NA 2.198 mg/L PBTK NA 95% Human Human -DTXSID2027543 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027543 Fup NA 0.9315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027543 Vd NA 0.9653 L/kg 1compartment NA NA Rat Human +DTXSID2027543 TK.Half.Life NA 8.628 hours 1compartment NA NA Human Human +DTXSID2027543 Css NA 1.287 mg/L 3compartmentss NA 50% Human Human +DTXSID2027543 Css NA 6.139 mg/L 3compartmentss NA 95% Human Human +DTXSID2027543 Css NA 0.9804 mg/L PBTK NA 50% Human Human +DTXSID2027543 Css NA 3.902 mg/L PBTK NA 95% Human Human +DTXSID2027543 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027543 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027543 Vd NA 0.6395 L/kg 1compartment NA NA Rat Human DTXSID2027543 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027543 TK.Half.Life NA 2.288 hours 1compartment NA NA Rat Human -DTXSID2027543 Css NA 0.2151 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027543 Css NA 0.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027543 Css NA 0.1828 mg/L PBTK NA 50% Rat Human -DTXSID2027543 Css NA 0.4858 mg/L PBTK NA 95% Rat Human -DTXSID2027591 Clint NA 5.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027591 Fup NA 0.5491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027591 Vd NA 0.693 L/kg 1compartment NA NA Human Human +DTXSID2027543 TK.Half.Life NA 2.975 hours 1compartment NA NA Rat Human +DTXSID2027543 Css NA 0.02372 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027543 Css NA 0.1639 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027543 Css NA 0.01747 mg/L PBTK NA 50% Rat Human +DTXSID2027543 Css NA 0.1054 mg/L PBTK NA 95% Rat Human +DTXSID2027591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027591 Fup 0.782 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027591 Vd NA 0.4708 L/kg 1compartment NA NA Human Human DTXSID2027591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027591 TK.Half.Life NA 1.113 hours 1compartment NA NA Human Human -DTXSID2027591 Css NA 0.1242 mg/L 3compartmentss NA 50% Human Human -DTXSID2027591 Css NA 1.066 mg/L 3compartmentss NA 95% Human Human -DTXSID2027591 Css NA 0.1028 mg/L PBTK NA 50% Human Human -DTXSID2027591 Css NA 0.7303 mg/L PBTK NA 95% Human Human -DTXSID2027591 Clint NA 5.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027591 Fup NA 0.5491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027591 Vd NA 0.6937 L/kg 1compartment NA NA Rat Human +DTXSID2027591 TK.Half.Life NA 3.894 hours 1compartment NA NA Human Human +DTXSID2027591 Css NA 0.9461 mg/L 3compartmentss NA 50% Human Human +DTXSID2027591 Css NA 5.647 mg/L 3compartmentss NA 95% Human Human +DTXSID2027591 Css NA 0.7143 mg/L PBTK NA 50% Human Human +DTXSID2027591 Css NA 3.579 mg/L PBTK NA 95% Human Human +DTXSID2027591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027591 Fup 0.782 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027591 Vd NA 0.5052 L/kg 1compartment NA NA Rat Human DTXSID2027591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027591 TK.Half.Life NA 0.6123 hours 1compartment NA NA Rat Human -DTXSID2027591 Css NA 0.06006 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027591 Css NA 0.4483 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027591 Css NA 0.04828 mg/L PBTK NA 50% Rat Human -DTXSID2027591 Css NA 0.2791 mg/L PBTK NA 95% Rat Human -DTXSID2027595 Clint NA 3.988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027595 Fup NA 0.2219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027595 Vd NA 0.6014 L/kg 1compartment NA NA Human Human +DTXSID2027591 TK.Half.Life NA 1.425 hours 1compartment NA NA Rat Human +DTXSID2027591 Css NA 0.02454 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027591 Css NA 0.1684 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027591 Css NA 0.01789 mg/L PBTK NA 50% Rat Human +DTXSID2027591 Css NA 0.1048 mg/L PBTK NA 95% Rat Human +DTXSID2027595 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027595 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027595 Vd NA 0.42 L/kg 1compartment NA NA Human Human DTXSID2027595 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027595 TK.Half.Life NA 2.649 hours 1compartment NA NA Human Human -DTXSID2027595 Css NA 0.4518 mg/L 3compartmentss NA 50% Human Human -DTXSID2027595 Css NA 2.473 mg/L 3compartmentss NA 95% Human Human -DTXSID2027595 Css NA 0.3334 mg/L PBTK NA 50% Human Human -DTXSID2027595 Css NA 1.658 mg/L PBTK NA 95% Human Human -DTXSID2027595 Clint NA 3.988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027595 Fup NA 0.2219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027595 Vd NA 0.5981 L/kg 1compartment NA NA Rat Human +DTXSID2027595 TK.Half.Life NA 6.691 hours 1compartment NA NA Human Human +DTXSID2027595 Css NA 1.809 mg/L 3compartmentss NA 50% Human Human +DTXSID2027595 Css NA 7.659 mg/L 3compartmentss NA 95% Human Human +DTXSID2027595 Css NA 1.288 mg/L PBTK NA 50% Human Human +DTXSID2027595 Css NA 4.743 mg/L PBTK NA 95% Human Human +DTXSID2027595 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027595 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027595 Vd NA 0.4469 L/kg 1compartment NA NA Rat Human DTXSID2027595 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027595 TK.Half.Life NA 1.528 hours 1compartment NA NA Rat Human -DTXSID2027595 Css NA 0.2214 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027595 Css NA 0.9295 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027595 Css NA 0.1556 mg/L PBTK NA 50% Rat Human -DTXSID2027595 Css NA 0.573 mg/L PBTK NA 95% Rat Human +DTXSID2027595 TK.Half.Life NA 2.428 hours 1compartment NA NA Rat Human +DTXSID2027595 Css NA 0.116 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027595 Css NA 0.4338 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027595 Css NA 0.08082 mg/L PBTK NA 50% Rat Human +DTXSID2027595 Css NA 0.261 mg/L PBTK NA 95% Rat Human DTXSID2027599 Clint NA 0.02482 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2027599 Fup NA 0.3822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027599 Vd NA 0.4949 L/kg 1compartment NA NA Human Human +DTXSID2027599 Vd NA 0.517 L/kg 1compartment NA NA Human Human DTXSID2027599 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027599 TK.Half.Life NA 8.024 hours 1compartment NA NA Human Human -DTXSID2027599 Css NA 1.814 mg/L 3compartmentss NA 50% Human Human -DTXSID2027599 Css NA 8.057 mg/L 3compartmentss NA 95% Human Human -DTXSID2027599 Css NA 1.321 mg/L PBTK NA 50% Human Human -DTXSID2027599 Css NA 5.053 mg/L PBTK NA 95% Human Human +DTXSID2027599 TK.Half.Life NA 8.391 hours 1compartment NA NA Human Human +DTXSID2027599 Css NA 1.527 mg/L 3compartmentss NA 50% Human Human +DTXSID2027599 Css NA 6.727 mg/L 3compartmentss NA 95% Human Human +DTXSID2027599 Css NA 1.127 mg/L PBTK NA 50% Human Human +DTXSID2027599 Css NA 4.26 mg/L PBTK NA 95% Human Human DTXSID2027599 Clint NA 0.02482 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2027599 Fup NA 0.3822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027599 Vd NA 0.5088 L/kg 1compartment NA NA Rat Human +DTXSID2027599 Vd NA 0.5292 L/kg 1compartment NA NA Rat Human DTXSID2027599 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027599 TK.Half.Life NA 2.874 hours 1compartment NA NA Rat Human -DTXSID2027599 Css NA 0.5134 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027599 Css NA 1.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027599 Css NA 0.3558 mg/L PBTK NA 50% Rat Human -DTXSID2027599 Css NA 1.125 mg/L PBTK NA 95% Rat Human -DTXSID2027620 Clint NA 15.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027620 Fup NA 0.6451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027620 Vd NA 1.383 L/kg 1compartment NA NA Human Human +DTXSID2027599 TK.Half.Life NA 2.989 hours 1compartment NA NA Rat Human +DTXSID2027599 Css NA 0.02858 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027599 Css NA 0.1817 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027599 Css NA 0.02027 mg/L PBTK NA 50% Rat Human +DTXSID2027599 Css NA 0.1159 mg/L PBTK NA 95% Rat Human +DTXSID2027620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027620 Fup 0.442 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027620 Vd NA 1.117 L/kg 1compartment NA NA Human Human DTXSID2027620 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027620 TK.Half.Life NA 1.315 hours 1compartment NA NA Human Human -DTXSID2027620 Css NA 0.04383 mg/L 3compartmentss NA 50% Human Human -DTXSID2027620 Css NA 0.4793 mg/L 3compartmentss NA 95% Human Human -DTXSID2027620 Css NA 0.03835 mg/L PBTK NA 50% Human Human -DTXSID2027620 Css NA 0.3422 mg/L PBTK NA 95% Human Human -DTXSID2027620 Clint NA 15.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027620 Fup NA 0.6451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027620 Vd NA 1.224 L/kg 1compartment NA NA Rat Human +DTXSID2027620 TK.Half.Life NA 1.176 hours 1compartment NA NA Human Human +DTXSID2027620 Css NA 0.04381 mg/L 3compartmentss NA 50% Human Human +DTXSID2027620 Css NA 0.351 mg/L 3compartmentss NA 95% Human Human +DTXSID2027620 Css NA 0.03471 mg/L PBTK NA 50% Human Human +DTXSID2027620 Css NA 0.2499 mg/L PBTK NA 95% Human Human +DTXSID2027620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027620 Fup 0.442 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027620 Vd NA 0.9838 L/kg 1compartment NA NA Rat Human DTXSID2027620 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027620 TK.Half.Life NA 0.5719 hours 1compartment NA NA Rat Human -DTXSID2027620 Css NA 0.02264 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027620 Css NA 0.1968 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027620 Css NA 0.01933 mg/L PBTK NA 50% Rat Human -DTXSID2027620 Css NA 0.1307 mg/L PBTK NA 95% Rat Human +DTXSID2027620 TK.Half.Life NA 0.5188 hours 1compartment NA NA Rat Human +DTXSID2027620 Css NA 0.00537 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027620 Css NA 0.03669 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027620 Css NA 0.004317 mg/L PBTK NA 50% Rat Human +DTXSID2027620 Css NA 0.02575 mg/L PBTK NA 95% Rat Human DTXSID2027624 Clint NA 0.6723 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2027624 Fup NA 0.7305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027624 Vd NA 0.5593 L/kg 1compartment NA NA Human Human +DTXSID2027624 Vd NA 0.5565 L/kg 1compartment NA NA Human Human DTXSID2027624 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027624 TK.Half.Life NA 2.28 hours 1compartment NA NA Human Human -DTXSID2027624 Css NA 0.4857 mg/L 3compartmentss NA 50% Human Human -DTXSID2027624 Css NA 3.127 mg/L 3compartmentss NA 95% Human Human -DTXSID2027624 Css NA 0.3771 mg/L PBTK NA 50% Human Human -DTXSID2027624 Css NA 1.964 mg/L PBTK NA 95% Human Human +DTXSID2027624 TK.Half.Life NA 0.5424 hours 1compartment NA NA Human Human +DTXSID2027624 Css NA 0.03884 mg/L 3compartmentss NA 50% Human Human +DTXSID2027624 Css NA 0.4033 mg/L 3compartmentss NA 95% Human Human +DTXSID2027624 Css NA 0.03005 mg/L PBTK NA 50% Human Human +DTXSID2027624 Css NA 0.2704 mg/L PBTK NA 95% Human Human DTXSID2027624 Clint NA 0.6723 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2027624 Fup NA 0.7305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027624 Vd NA 0.6047 L/kg 1compartment NA NA Rat Human +DTXSID2027624 Vd NA 0.6026 L/kg 1compartment NA NA Rat Human DTXSID2027624 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027624 TK.Half.Life NA 1.148 hours 1compartment NA NA Rat Human -DTXSID2027624 Css NA 0.177 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027624 Css NA 1.096 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027624 Css NA 0.1339 mg/L PBTK NA 50% Rat Human -DTXSID2027624 Css NA 0.643 mg/L PBTK NA 95% Rat Human -DTXSID2027759 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027759 Fup NA 0.9357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027759 Vd NA 1.887 L/kg 1compartment NA NA Human Human +DTXSID2027624 TK.Half.Life NA 0.295 hours 1compartment NA NA Rat Human +DTXSID2027624 Css NA 0.00139 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027624 Css NA 0.01563 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027624 Css NA 0.001046 mg/L PBTK NA 50% Rat Human +DTXSID2027624 Css NA 0.01023 mg/L PBTK NA 95% Rat Human +DTXSID2027759 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027759 Fup 0.82 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027759 Vd NA 1.742 L/kg 1compartment NA NA Human Human DTXSID2027759 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2027759 TK.Half.Life NA 13.34 hours 1compartment NA NA Human Human -DTXSID2027759 Css NA 0.7707 mg/L 3compartmentss NA 50% Human Human -DTXSID2027759 Css NA 4.674 mg/L 3compartmentss NA 95% Human Human -DTXSID2027759 Css NA 0.7599 mg/L PBTK NA 50% Human Human -DTXSID2027759 Css NA 3.261 mg/L PBTK NA 95% Human Human -DTXSID2027759 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027759 Fup NA 0.9357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027759 Vd NA 1.888 L/kg 1compartment NA NA Rat Human +DTXSID2027759 TK.Half.Life NA 14.02 hours 1compartment NA NA Human Human +DTXSID2027759 Css NA 0.8111 mg/L 3compartmentss NA 50% Human Human +DTXSID2027759 Css NA 5.463 mg/L 3compartmentss NA 95% Human Human +DTXSID2027759 Css NA 0.7913 mg/L PBTK NA 50% Human Human +DTXSID2027759 Css NA 3.702 mg/L PBTK NA 95% Human Human +DTXSID2027759 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027759 Fup 0.82 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027759 Vd NA 1.74 L/kg 1compartment NA NA Rat Human DTXSID2027759 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027759 TK.Half.Life NA 4.472 hours 1compartment NA NA Rat Human -DTXSID2027759 Css NA 0.1929 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027759 Css NA 1.194 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027759 Css NA 0.1888 mg/L PBTK NA 50% Rat Human -DTXSID2027759 Css NA 0.7728 mg/L PBTK NA 95% Rat Human -DTXSID2027830 Clint NA 4.132 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027830 Fup NA 0.3576 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027830 Vd NA 0.8379 L/kg 1compartment NA NA Human Human +DTXSID2027759 TK.Half.Life NA 4.699 hours 1compartment NA NA Rat Human +DTXSID2027759 Css NA 0.04788 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027759 Css NA 0.3104 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027759 Css NA 0.04717 mg/L PBTK NA 50% Rat Human +DTXSID2027759 Css NA 0.2042 mg/L PBTK NA 95% Rat Human +DTXSID2027830 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027830 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027830 Vd NA 0.6911 L/kg 1compartment NA NA Human Human DTXSID2027830 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027830 TK.Half.Life NA 2.436 hours 1compartment NA NA Human Human -DTXSID2027830 Css NA 0.2742 mg/L 3compartmentss NA 50% Human Human -DTXSID2027830 Css NA 1.582 mg/L 3compartmentss NA 95% Human Human -DTXSID2027830 Css NA 0.2053 mg/L PBTK NA 50% Human Human -DTXSID2027830 Css NA 1.061 mg/L PBTK NA 95% Human Human -DTXSID2027830 Clint NA 4.132 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027830 Fup NA 0.3576 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027830 Vd NA 0.7599 L/kg 1compartment NA NA Rat Human +DTXSID2027830 TK.Half.Life NA 2.014 hours 1compartment NA NA Human Human +DTXSID2027830 Css NA 0.2636 mg/L 3compartmentss NA 50% Human Human +DTXSID2027830 Css NA 1.712 mg/L 3compartmentss NA 95% Human Human +DTXSID2027830 Css NA 0.1867 mg/L PBTK NA 50% Human Human +DTXSID2027830 Css NA 1.1 mg/L PBTK NA 95% Human Human +DTXSID2027830 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027830 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027830 Vd NA 0.6253 L/kg 1compartment NA NA Rat Human DTXSID2027830 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027830 TK.Half.Life NA 1.218 hours 1compartment NA NA Rat Human -DTXSID2027830 Css NA 0.1322 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027830 Css NA 0.5972 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027830 Css NA 0.09613 mg/L PBTK NA 50% Rat Human -DTXSID2027830 Css NA 0.3699 mg/L PBTK NA 95% Rat Human -DTXSID2027834 Clint NA 1.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027834 Fup NA 0.5515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027834 Vd NA 0.4173 L/kg 1compartment NA NA Human Human +DTXSID2027830 TK.Half.Life NA 1.039 hours 1compartment NA NA Rat Human +DTXSID2027830 Css NA 0.03209 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027830 Css NA 0.1383 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027830 Css NA 0.02238 mg/L PBTK NA 50% Rat Human +DTXSID2027830 Css NA 0.08701 mg/L PBTK NA 95% Rat Human +DTXSID2027834 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027834 Fup 0.82 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027834 Vd NA 0.4964 L/kg 1compartment NA NA Human Human DTXSID2027834 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2027834 TK.Half.Life NA 1.766 hours 1compartment NA NA Human Human -DTXSID2027834 Css NA 0.4916 mg/L 3compartmentss NA 50% Human Human -DTXSID2027834 Css NA 3.232 mg/L 3compartmentss NA 95% Human Human -DTXSID2027834 Css NA 0.3501 mg/L PBTK NA 50% Human Human -DTXSID2027834 Css NA 2.021 mg/L PBTK NA 95% Human Human -DTXSID2027834 Clint NA 1.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027834 Fup NA 0.5515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027834 Vd NA 0.4284 L/kg 1compartment NA NA Rat Human +DTXSID2027834 TK.Half.Life NA 3.918 hours 1compartment NA NA Human Human +DTXSID2027834 Css NA 1.044 mg/L 3compartmentss NA 50% Human Human +DTXSID2027834 Css NA 5.866 mg/L 3compartmentss NA 95% Human Human +DTXSID2027834 Css NA 0.7838 mg/L PBTK NA 50% Human Human +DTXSID2027834 Css NA 3.676 mg/L PBTK NA 95% Human Human +DTXSID2027834 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027834 Fup 0.82 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027834 Vd NA 0.5136 L/kg 1compartment NA NA Rat Human DTXSID2027834 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2027834 TK.Half.Life NA 0.9015 hours 1compartment NA NA Rat Human -DTXSID2027834 Css NA 0.1969 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027834 Css NA 1.191 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027834 Css NA 0.1347 mg/L PBTK NA 50% Rat Human -DTXSID2027834 Css NA 0.6775 mg/L PBTK NA 95% Rat Human -DTXSID2027886 Clint NA 13.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027886 Fup NA 0.0093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027886 Vd NA 2.846 L/kg 1compartment NA NA Human Human -DTXSID2027886 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID2027886 TK.Half.Life NA 97.81 hours 1compartment NA NA Human Human -DTXSID2027886 Css NA 4.714 mg/L 3compartmentss NA 50% Human Human -DTXSID2027886 Css NA 30.12 mg/L 3compartmentss NA 95% Human Human -DTXSID2027886 Css NA 3.186 mg/L PBTK NA 50% Human Human -DTXSID2027886 Css NA 19.92 mg/L PBTK NA 95% Human Human -DTXSID2027886 Clint NA 13.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027886 Fup NA 0.0093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027886 Vd NA 2.127 L/kg 1compartment NA NA Rat Human -DTXSID2027886 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID2027886 TK.Half.Life NA 17.89 hours 1compartment NA NA Rat Human -DTXSID2027886 Css NA 2.61 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027886 Css NA 14.64 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027886 Css NA 1.678 mg/L PBTK NA 50% Rat Human -DTXSID2027886 Css NA 8.979 mg/L PBTK NA 95% Rat Human -DTXSID2027963 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027963 Fup NA 0.0069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2027963 Vd NA 9.457 L/kg 1compartment NA NA Human Human -DTXSID2027963 Days.Css NA 3150 Days PBTK NA NA Human Human -DTXSID2027963 TK.Half.Life NA 11500 hours 1compartment NA NA Human Human -DTXSID2027963 Css NA 111.7 mg/L 3compartmentss NA 50% Human Human -DTXSID2027963 Css NA 877.4 mg/L 3compartmentss NA 95% Human Human -DTXSID2027963 Css NA 120.5 mg/L PBTK NA 50% Human Human -DTXSID2027963 Css NA 621.3 mg/L PBTK NA 95% Human Human -DTXSID2027963 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027963 Fup NA 0.0069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2027963 Vd NA 7.445 L/kg 1compartment NA NA Rat Human -DTXSID2027963 Days.Css NA 842 Days PBTK NA NA Rat Human -DTXSID2027963 TK.Half.Life NA 2547 hours 1compartment NA NA Rat Human -DTXSID2027963 Css NA 29.76 mg/L 3compartmentss NA 50% Rat Human -DTXSID2027963 Css NA 220 mg/L 3compartmentss NA 95% Rat Human -DTXSID2027963 Css NA 31.72 mg/L PBTK NA 50% Rat Human -DTXSID2027963 Css NA 144.3 mg/L PBTK NA 95% Rat Human -DTXSID2028010 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2028010 Fup NA 0.8201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2028010 Vd NA 0.9206 L/kg 1compartment NA NA Human Human +DTXSID2027834 TK.Half.Life NA 1.381 hours 1compartment NA NA Rat Human +DTXSID2027834 Css NA 0.06252 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027834 Css NA 0.3472 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027834 Css NA 0.04654 mg/L PBTK NA 50% Rat Human +DTXSID2027834 Css NA 0.2083 mg/L PBTK NA 95% Rat Human +DTXSID2027886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027886 Fup 0.00966 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2027886 Vd NA 6.837 L/kg 1compartment NA NA Human Human +DTXSID2027886 Days.Css NA 40 Days PBTK NA NA Human Human +DTXSID2027886 TK.Half.Life NA 205.9 hours 1compartment NA NA Human Human +DTXSID2027886 Css NA 2.555 mg/L 3compartmentss NA 50% Human Human +DTXSID2027886 Css NA 15.2 mg/L 3compartmentss NA 95% Human Human +DTXSID2027886 Css NA 2.399 mg/L PBTK NA 50% Human Human +DTXSID2027886 Css NA 14.15 mg/L PBTK NA 95% Human Human +DTXSID2027886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027886 Fup 0.00966 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2027886 Vd NA 5.291 L/kg 1compartment NA NA Rat Human +DTXSID2027886 Days.Css NA 23 Days PBTK NA NA Rat Human +DTXSID2027886 TK.Half.Life NA 28.7 hours 1compartment NA NA Rat Human +DTXSID2027886 Css NA 0.3264 mg/L 3compartmentss NA 50% Rat Human +DTXSID2027886 Css NA 1.545 mg/L 3compartmentss NA 95% Rat Human +DTXSID2027886 Css NA 0.3114 mg/L PBTK NA 50% Rat Human +DTXSID2027886 Css NA 1.575 mg/L PBTK NA 95% Rat Human +DTXSID2028010 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2028010 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2028010 Vd NA 0.8586 L/kg 1compartment NA NA Human Human DTXSID2028010 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2028010 TK.Half.Life NA 7.355 hours 1compartment NA NA Human Human -DTXSID2028010 Css NA 0.9366 mg/L 3compartmentss NA 50% Human Human -DTXSID2028010 Css NA 6.148 mg/L 3compartmentss NA 95% Human Human -DTXSID2028010 Css NA 0.8042 mg/L PBTK NA 50% Human Human -DTXSID2028010 Css NA 4.001 mg/L PBTK NA 95% Human Human -DTXSID2028010 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2028010 Fup NA 0.8201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2028010 Vd NA 0.915 L/kg 1compartment NA NA Rat Human +DTXSID2028010 TK.Half.Life NA 0.831 hours 1compartment NA NA Human Human +DTXSID2028010 Css NA 0.03649 mg/L 3compartmentss NA 50% Human Human +DTXSID2028010 Css NA 0.3423 mg/L 3compartmentss NA 95% Human Human +DTXSID2028010 Css NA 0.02926 mg/L PBTK NA 50% Human Human +DTXSID2028010 Css NA 0.2391 mg/L PBTK NA 95% Human Human +DTXSID2028010 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2028010 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2028010 Vd NA 0.8132 L/kg 1compartment NA NA Rat Human DTXSID2028010 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2028010 TK.Half.Life NA 2.468 hours 1compartment NA NA Rat Human -DTXSID2028010 Css NA 0.2386 mg/L 3compartmentss NA 50% Rat Human -DTXSID2028010 Css NA 1.451 mg/L 3compartmentss NA 95% Rat Human -DTXSID2028010 Css NA 0.2 mg/L PBTK NA 50% Rat Human -DTXSID2028010 Css NA 0.8819 mg/L PBTK NA 95% Rat Human -DTXSID2028723 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2028723 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2028723 Vd NA 0.5326 L/kg 1compartment NA NA Human Human -DTXSID2028723 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2028723 TK.Half.Life NA 9.524 hours 1compartment NA NA Human Human -DTXSID2028723 Css NA 3.125 mg/L 3compartmentss NA 50% Human Human -DTXSID2028723 Css NA 32.01 mg/L 3compartmentss NA 95% Human Human -DTXSID2028723 Css NA 1.898 mg/L PBTK NA 50% Human Human -DTXSID2028723 Css NA 18.94 mg/L PBTK NA 95% Human Human -DTXSID2028723 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2028723 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2028723 Vd NA 0.4356 L/kg 1compartment NA NA Rat Human -DTXSID2028723 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2028723 TK.Half.Life NA 5.154 hours 1compartment NA NA Rat Human -DTXSID2028723 Css NA 1.819 mg/L 3compartmentss NA 50% Rat Human -DTXSID2028723 Css NA 15.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID2028723 Css NA 1.034 mg/L PBTK NA 50% Rat Human -DTXSID2028723 Css NA 8.561 mg/L PBTK NA 95% Rat Human -DTXSID2029117 Clint NA 39.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029117 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029117 Vd NA 3.124 L/kg 1compartment NA NA Human Human -DTXSID2029117 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID2029117 TK.Half.Life NA 52.08 hours 1compartment NA NA Human Human -DTXSID2029117 Css NA 1.959 mg/L 3compartmentss NA 50% Human Human -DTXSID2029117 Css NA 11.12 mg/L 3compartmentss NA 95% Human Human -DTXSID2029117 Css NA 1.354 mg/L PBTK NA 50% Human Human -DTXSID2029117 Css NA 7.582 mg/L PBTK NA 95% Human Human -DTXSID2029117 Clint NA 39.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029117 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029117 Vd NA 2.34 L/kg 1compartment NA NA Rat Human -DTXSID2029117 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2029117 TK.Half.Life NA 7.183 hours 1compartment NA NA Rat Human -DTXSID2029117 Css NA 1.107 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029117 Css NA 4.759 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029117 Css NA 0.735 mg/L PBTK NA 50% Rat Human -DTXSID2029117 Css NA 3.084 mg/L PBTK NA 95% Rat Human +DTXSID2028010 TK.Half.Life NA 0.395 hours 1compartment NA NA Rat Human +DTXSID2028010 Css NA 0.004525 mg/L 3compartmentss NA 50% Rat Human +DTXSID2028010 Css NA 0.03549 mg/L 3compartmentss NA 95% Rat Human +DTXSID2028010 Css NA 0.003636 mg/L PBTK NA 50% Rat Human +DTXSID2028010 Css NA 0.02418 mg/L PBTK NA 95% Rat Human +DTXSID2029117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2029117 Fup 0.0055 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2029117 Vd NA 3.055 L/kg 1compartment NA NA Human Human +DTXSID2029117 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID2029117 TK.Half.Life NA 90.23 hours 1compartment NA NA Human Human +DTXSID2029117 Css NA 3.609 mg/L 3compartmentss NA 50% Human Human +DTXSID2029117 Css NA 22.91 mg/L 3compartmentss NA 95% Human Human +DTXSID2029117 Css NA 2.479 mg/L PBTK NA 50% Human Human +DTXSID2029117 Css NA 15.6 mg/L PBTK NA 95% Human Human +DTXSID2029117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2029117 Fup 0.0055 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2029117 Vd NA 2.288 L/kg 1compartment NA NA Rat Human +DTXSID2029117 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID2029117 TK.Half.Life NA 13.2 hours 1compartment NA NA Rat Human +DTXSID2029117 Css NA 0.4716 mg/L 3compartmentss NA 50% Rat Human +DTXSID2029117 Css NA 2.47 mg/L 3compartmentss NA 95% Rat Human +DTXSID2029117 Css NA 0.3211 mg/L PBTK NA 50% Rat Human +DTXSID2029117 Css NA 1.697 mg/L PBTK NA 95% Rat Human DTXSID2029167 Clint NA 1.893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2029167 Fup NA 0.9789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029167 Vd NA 1.142 L/kg 1compartment NA NA Human Human +DTXSID2029167 Vd NA 0.5523 L/kg 1compartment NA NA Human Human DTXSID2029167 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2029167 TK.Half.Life NA 2.213 hours 1compartment NA NA Human Human -DTXSID2029167 Css NA 0.2054 mg/L 3compartmentss NA 50% Human Human -DTXSID2029167 Css NA 1.461 mg/L 3compartmentss NA 95% Human Human -DTXSID2029167 Css NA 0.1825 mg/L PBTK NA 50% Human Human -DTXSID2029167 Css NA 1.02 mg/L PBTK NA 95% Human Human +DTXSID2029167 TK.Half.Life NA 1.059 hours 1compartment NA NA Human Human +DTXSID2029167 Css NA 0.1911 mg/L 3compartmentss NA 50% Human Human +DTXSID2029167 Css NA 1.248 mg/L 3compartmentss NA 95% Human Human +DTXSID2029167 Css NA 0.1458 mg/L PBTK NA 50% Human Human +DTXSID2029167 Css NA 0.8171 mg/L PBTK NA 95% Human Human DTXSID2029167 Clint NA 1.893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2029167 Fup NA 0.9789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029167 Vd NA 1.114 L/kg 1compartment NA NA Rat Human +DTXSID2029167 Vd NA 0.5729 L/kg 1compartment NA NA Rat Human DTXSID2029167 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2029167 TK.Half.Life NA 1.091 hours 1compartment NA NA Rat Human -DTXSID2029167 Css NA 0.08368 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029167 Css NA 0.5264 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029167 Css NA 0.07428 mg/L PBTK NA 50% Rat Human -DTXSID2029167 Css NA 0.3334 mg/L PBTK NA 95% Rat Human -DTXSID2029169 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029169 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029169 Vd NA 7.896 L/kg 1compartment NA NA Human Human -DTXSID2029169 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID2029169 TK.Half.Life NA 107500 hours 1compartment NA NA Human Human -DTXSID2029169 Css NA 1073 mg/L 3compartmentss NA 50% Human Human -DTXSID2029169 Css NA 3313 mg/L 3compartmentss NA 95% Human Human -DTXSID2029169 Css NA 1098 mg/L PBTK NA 50% Human Human -DTXSID2029169 Css NA 2842 mg/L PBTK NA 95% Human Human -DTXSID2029169 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029169 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029169 Vd NA 6.163 L/kg 1compartment NA NA Rat Human -DTXSID2029169 Days.Css NA 7904 Days PBTK NA NA Rat Human -DTXSID2029169 TK.Half.Life NA 7380 hours 1compartment NA NA Rat Human -DTXSID2029169 Css NA 279.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029169 Css NA 746.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029169 Css NA 284.7 mg/L PBTK NA 50% Rat Human -DTXSID2029169 Css NA 579.3 mg/L PBTK NA 95% Rat Human -DTXSID2029242 Clint NA 96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029242 Fup NA 0.6307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029242 Vd NA 0.6888 L/kg 1compartment NA NA Human Human +DTXSID2029167 TK.Half.Life NA 0.5585 hours 1compartment NA NA Rat Human +DTXSID2029167 Css NA 0.005862 mg/L 3compartmentss NA 50% Rat Human +DTXSID2029167 Css NA 0.04853 mg/L 3compartmentss NA 95% Rat Human +DTXSID2029167 Css NA 0.004336 mg/L PBTK NA 50% Rat Human +DTXSID2029167 Css NA 0.03145 mg/L PBTK NA 95% Rat Human +DTXSID2029169 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2029169 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2029169 Vd NA 2.916 L/kg 1compartment NA NA Human Human +DTXSID2029169 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2029169 TK.Half.Life NA 21.98 hours 1compartment NA NA Human Human +DTXSID2029169 Css NA 0.4964 mg/L 3compartmentss NA 50% Human Human +DTXSID2029169 Css NA 3.836 mg/L 3compartmentss NA 95% Human Human +DTXSID2029169 Css NA 0.3414 mg/L PBTK NA 50% Human Human +DTXSID2029169 Css NA 2.542 mg/L PBTK NA 95% Human Human +DTXSID2029169 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2029169 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2029169 Vd NA 2.224 L/kg 1compartment NA NA Rat Human +DTXSID2029169 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2029169 TK.Half.Life NA 4.63 hours 1compartment NA NA Rat Human +DTXSID2029169 Css NA 0.005336 mg/L 3compartmentss NA 50% Rat Human +DTXSID2029169 Css NA 0.03733 mg/L 3compartmentss NA 95% Rat Human +DTXSID2029169 Css NA 0.003519 mg/L PBTK NA 50% Rat Human +DTXSID2029169 Css NA 0.02342 mg/L PBTK NA 95% Rat Human +DTXSID2029242 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2029242 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2029242 Vd NA 0.7304 L/kg 1compartment NA NA Human Human DTXSID2029242 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2029242 TK.Half.Life NA 0.4871 hours 1compartment NA NA Human Human -DTXSID2029242 Css NA 0.008107 mg/L 3compartmentss NA 50% Human Human -DTXSID2029242 Css NA 0.09504 mg/L 3compartmentss NA 95% Human Human -DTXSID2029242 Css NA 0.006324 mg/L PBTK NA 50% Human Human -DTXSID2029242 Css NA 0.06443 mg/L PBTK NA 95% Human Human -DTXSID2029242 Clint NA 96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029242 Fup NA 0.6307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029242 Vd NA 0.7106 L/kg 1compartment NA NA Rat Human +DTXSID2029242 TK.Half.Life NA 6.802 hours 1compartment NA NA Human Human +DTXSID2029242 Css NA 0.9416 mg/L 3compartmentss NA 50% Human Human +DTXSID2029242 Css NA 6.426 mg/L 3compartmentss NA 95% Human Human +DTXSID2029242 Css NA 0.7638 mg/L PBTK NA 50% Human Human +DTXSID2029242 Css NA 4.078 mg/L PBTK NA 95% Human Human +DTXSID2029242 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2029242 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2029242 Vd NA 0.7536 L/kg 1compartment NA NA Rat Human DTXSID2029242 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2029242 TK.Half.Life NA 0.2261 hours 1compartment NA NA Rat Human -DTXSID2029242 Css NA 0.004281 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029242 Css NA 0.04215 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029242 Css NA 0.003292 mg/L PBTK NA 50% Rat Human -DTXSID2029242 Css NA 0.02709 mg/L PBTK NA 95% Rat Human -DTXSID2029246 Clint 11.06 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID2029246 Fup 0.026 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID2029246 Vd NA 2.95 L/kg 1compartment NA NA Human Human -DTXSID2029246 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID2029246 TK.Half.Life NA 94.49 hours 1compartment NA NA Human Human -DTXSID2029246 Css NA 3.991 mg/L 3compartmentss NA 50% Human Human -DTXSID2029246 Css NA 24.61 mg/L 3compartmentss NA 95% Human Human -DTXSID2029246 Css NA 2.756 mg/L PBTK NA 50% Human Human -DTXSID2029246 Css NA 16.34 mg/L PBTK NA 95% Human Human -DTXSID2029246 Clint 11.06 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID2029246 Fup 0.026 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID2029246 Vd NA 2.21 L/kg 1compartment NA NA Rat Human -DTXSID2029246 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID2029246 TK.Half.Life NA 15.57 hours 1compartment NA NA Rat Human -DTXSID2029246 Css NA 2.225 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029246 Css NA 10.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029246 Css NA 1.462 mg/L PBTK NA 50% Rat Human -DTXSID2029246 Css NA 6.943 mg/L PBTK NA 95% Rat Human -DTXSID2029298 Clint NA 0.7467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029298 Fup NA 0.0334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029298 Vd NA 0.3966 L/kg 1compartment NA NA Human Human -DTXSID2029298 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID2029298 TK.Half.Life NA 34.21 hours 1compartment NA NA Human Human -DTXSID2029298 Css NA 15.11 mg/L 3compartmentss NA 50% Human Human -DTXSID2029298 Css NA 77.3 mg/L 3compartmentss NA 95% Human Human -DTXSID2029298 Css NA 9.403 mg/L PBTK NA 50% Human Human -DTXSID2029298 Css NA 45.78 mg/L PBTK NA 95% Human Human -DTXSID2029298 Clint NA 0.7467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029298 Fup NA 0.0334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029298 Vd NA 0.3809 L/kg 1compartment NA NA Rat Human -DTXSID2029298 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2029298 TK.Half.Life NA 15.64 hours 1compartment NA NA Rat Human -DTXSID2029298 Css NA 6.025 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029298 Css NA 26.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029298 Css NA 3.524 mg/L PBTK NA 50% Rat Human -DTXSID2029298 Css NA 14.41 mg/L PBTK NA 95% Rat Human -DTXSID2029325 Clint NA 0.5411 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029325 Fup NA 0.1999 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029325 Vd NA 2.867 L/kg 1compartment NA NA Human Human -DTXSID2029325 Days.Css NA 51 Days PBTK NA NA Human Human -DTXSID2029325 TK.Half.Life NA 241.9 hours 1compartment NA NA Human Human -DTXSID2029325 Css NA 9.616 mg/L 3compartmentss NA 50% Human Human -DTXSID2029325 Css NA 31.13 mg/L 3compartmentss NA 95% Human Human -DTXSID2029325 Css NA 6.938 mg/L PBTK NA 50% Human Human -DTXSID2029325 Css NA 20.59 mg/L PBTK NA 95% Human Human -DTXSID2029325 Clint NA 0.5411 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029325 Fup NA 0.1999 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029325 Vd NA 2.167 L/kg 1compartment NA NA Rat Human -DTXSID2029325 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID2029325 TK.Half.Life NA 32.11 hours 1compartment NA NA Rat Human -DTXSID2029325 Css NA 3.771 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029325 Css NA 8.84 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029325 Css NA 2.602 mg/L PBTK NA 50% Rat Human -DTXSID2029325 Css NA 5.466 mg/L PBTK NA 95% Rat Human -DTXSID2029329 Clint NA 6.368 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029329 Fup NA 0.5001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029329 Vd NA 0.8036 L/kg 1compartment NA NA Human Human -DTXSID2029329 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2029329 TK.Half.Life NA 1.361 hours 1compartment NA NA Human Human -DTXSID2029329 Css NA 0.1291 mg/L 3compartmentss NA 50% Human Human -DTXSID2029329 Css NA 0.9445 mg/L 3compartmentss NA 95% Human Human -DTXSID2029329 Css NA 0.1024 mg/L PBTK NA 50% Human Human -DTXSID2029329 Css NA 0.6329 mg/L PBTK NA 95% Human Human -DTXSID2029329 Clint NA 6.368 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029329 Fup NA 0.5001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029329 Vd NA 0.7689 L/kg 1compartment NA NA Rat Human -DTXSID2029329 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2029329 TK.Half.Life NA 0.7095 hours 1compartment NA NA Rat Human -DTXSID2029329 Css NA 0.06454 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029329 Css NA 0.394 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029329 Css NA 0.04939 mg/L PBTK NA 50% Rat Human -DTXSID2029329 Css NA 0.2444 mg/L PBTK NA 95% Rat Human +DTXSID2029242 TK.Half.Life NA 2.391 hours 1compartment NA NA Rat Human +DTXSID2029242 Css NA 0.02466 mg/L 3compartmentss NA 50% Rat Human +DTXSID2029242 Css NA 0.1866 mg/L 3compartmentss NA 95% Rat Human +DTXSID2029242 Css NA 0.01947 mg/L PBTK NA 50% Rat Human +DTXSID2029242 Css NA 0.117 mg/L PBTK NA 95% Rat Human +DTXSID2029325 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2029325 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2029325 Vd NA 2.094 L/kg 1compartment NA NA Human Human +DTXSID2029325 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2029325 TK.Half.Life NA 4.618 hours 1compartment NA NA Human Human +DTXSID2029325 Css NA 0.1721 mg/L 3compartmentss NA 50% Human Human +DTXSID2029325 Css NA 1.172 mg/L 3compartmentss NA 95% Human Human +DTXSID2029325 Css NA 0.1244 mg/L PBTK NA 50% Human Human +DTXSID2029325 Css NA 0.7999 mg/L PBTK NA 95% Human Human +DTXSID2029325 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2029325 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2029325 Vd NA 1.609 L/kg 1compartment NA NA Rat Human +DTXSID2029325 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2029325 TK.Half.Life NA 1.522 hours 1compartment NA NA Rat Human +DTXSID2029325 Css NA 0.02202 mg/L 3compartmentss NA 50% Rat Human +DTXSID2029325 Css NA 0.1079 mg/L 3compartmentss NA 95% Rat Human +DTXSID2029325 Css NA 0.01574 mg/L PBTK NA 50% Rat Human +DTXSID2029325 Css NA 0.07492 mg/L PBTK NA 95% Rat Human DTXSID2029616 Clint NA 0.3491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2029616 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2029616 Vd NA 1.013 L/kg 1compartment NA NA Human Human DTXSID2029616 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2029616 TK.Half.Life NA 4.252 hours 1compartment NA NA Human Human -DTXSID2029616 Css NA 0.4869 mg/L 3compartmentss NA 50% Human Human -DTXSID2029616 Css NA 3.463 mg/L 3compartmentss NA 95% Human Human -DTXSID2029616 Css NA 0.4315 mg/L PBTK NA 50% Human Human -DTXSID2029616 Css NA 2.265 mg/L PBTK NA 95% Human Human +DTXSID2029616 Css NA 0.4123 mg/L 3compartmentss NA 50% Human Human +DTXSID2029616 Css NA 2.754 mg/L 3compartmentss NA 95% Human Human +DTXSID2029616 Css NA 0.3646 mg/L PBTK NA 50% Human Human +DTXSID2029616 Css NA 1.91 mg/L PBTK NA 95% Human Human DTXSID2029616 Clint NA 0.3491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2029616 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2029616 Vd NA 1.029 L/kg 1compartment NA NA Rat Human DTXSID2029616 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2029616 TK.Half.Life NA 1.786 hours 1compartment NA NA Rat Human -DTXSID2029616 Css NA 0.1541 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029616 Css NA 1.017 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029616 Css NA 0.1347 mg/L PBTK NA 50% Rat Human -DTXSID2029616 Css NA 0.6278 mg/L PBTK NA 95% Rat Human -DTXSID2029662 Clint NA 415.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029662 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029662 Vd NA 4230 L/kg 1compartment NA NA Human Human -DTXSID2029662 Days.Css NA 1745 Days PBTK NA NA Human Human -DTXSID2029662 TK.Half.Life NA 6533 hours 1compartment NA NA Human Human -DTXSID2029662 Css NA 0.0001697 mg/L 3compartmentss NA 50% Human Human -DTXSID2029662 Css NA 0.001078 mg/L 3compartmentss NA 95% Human Human -DTXSID2029662 Css NA 0.1278 mg/L PBTK NA 50% Human Human -DTXSID2029662 Css NA 0.7279 mg/L PBTK NA 95% Human Human -DTXSID2029662 Clint NA 415.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029662 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029662 Vd NA 3950 L/kg 1compartment NA NA Rat Human -DTXSID2029662 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID2029662 TK.Half.Life NA 1062 hours 1compartment NA NA Rat Human -DTXSID2029662 Css NA 8.662e-05 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029662 Css NA 0.0003581 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029662 Css NA 0.06964 mg/L PBTK NA 50% Rat Human -DTXSID2029662 Css NA 0.2877 mg/L PBTK NA 95% Rat Human -DTXSID2029668 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029668 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2029668 Vd NA 2.278 L/kg 1compartment NA NA Human Human -DTXSID2029668 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID2029668 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human -DTXSID2029668 Css NA 5.766 mg/L 3compartmentss NA 50% Human Human -DTXSID2029668 Css NA 18.35 mg/L 3compartmentss NA 95% Human Human -DTXSID2029668 Css NA 4.315 mg/L PBTK NA 50% Human Human -DTXSID2029668 Css NA 12.3 mg/L PBTK NA 95% Human Human -DTXSID2029668 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029668 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2029668 Vd NA 1.758 L/kg 1compartment NA NA Rat Human -DTXSID2029668 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID2029668 TK.Half.Life NA 18.69 hours 1compartment NA NA Rat Human -DTXSID2029668 Css NA 1.568 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029668 Css NA 4.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029668 Css NA 1.13 mg/L PBTK NA 50% Rat Human -DTXSID2029668 Css NA 2.563 mg/L PBTK NA 95% Rat Human +DTXSID2029616 Css NA 0.009186 mg/L 3compartmentss NA 50% Rat Human +DTXSID2029616 Css NA 0.08146 mg/L 3compartmentss NA 95% Rat Human +DTXSID2029616 Css NA 0.008039 mg/L PBTK NA 50% Rat Human +DTXSID2029616 Css NA 0.05427 mg/L PBTK NA 95% Rat Human DTXSID2029874 Clint 563 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2029874 Fup 0.00815 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2029874 Vd NA 2.799 L/kg 1compartment NA NA Human Human +DTXSID2029874 Vd NA 2.977 L/kg 1compartment NA NA Human Human DTXSID2029874 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2029874 TK.Half.Life NA 4.633 hours 1compartment NA NA Human Human -DTXSID2029874 Css NA 0.1216 mg/L 3compartmentss NA 50% Human Human -DTXSID2029874 Css NA 0.8854 mg/L 3compartmentss NA 95% Human Human -DTXSID2029874 Css NA 0.08121 mg/L PBTK NA 50% Human Human -DTXSID2029874 Css NA 0.5799 mg/L PBTK NA 95% Human Human +DTXSID2029874 TK.Half.Life NA 5.271 hours 1compartment NA NA Human Human +DTXSID2029874 Css NA 0.1248 mg/L 3compartmentss NA 50% Human Human +DTXSID2029874 Css NA 0.8823 mg/L 3compartmentss NA 95% Human Human +DTXSID2029874 Css NA 0.08484 mg/L PBTK NA 50% Human Human +DTXSID2029874 Css NA 0.5785 mg/L PBTK NA 95% Human Human DTXSID2029874 Clint 563 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2029874 Fup 0.00815 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2029874 Vd NA 2.09 L/kg 1compartment NA NA Rat Human +DTXSID2029874 Vd NA 2.227 L/kg 1compartment NA NA Rat Human DTXSID2029874 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2029874 TK.Half.Life NA 1.202 hours 1compartment NA NA Rat Human -DTXSID2029874 Css NA 0.06954 mg/L 3compartmentss NA 50% Rat Human -DTXSID2029874 Css NA 0.422 mg/L 3compartmentss NA 95% Rat Human -DTXSID2029874 Css NA 0.04443 mg/L PBTK NA 50% Rat Human -DTXSID2029874 Css NA 0.2601 mg/L PBTK NA 95% Rat Human -DTXSID2030695 Clint NA 7.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2030695 Fup NA 0.0535 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2030695 Vd NA 0.2762 L/kg 1compartment NA NA Human Human +DTXSID2029874 TK.Half.Life NA 1.246 hours 1compartment NA NA Rat Human +DTXSID2029874 Css NA 0.01636 mg/L 3compartmentss NA 50% Rat Human +DTXSID2029874 Css NA 0.1012 mg/L 3compartmentss NA 95% Rat Human +DTXSID2029874 Css NA 0.01101 mg/L PBTK NA 50% Rat Human +DTXSID2029874 Css NA 0.06571 mg/L PBTK NA 95% Rat Human +DTXSID2030695 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2030695 Fup 0.0521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2030695 Vd NA 0.331 L/kg 1compartment NA NA Human Human DTXSID2030695 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2030695 TK.Half.Life NA 2.764 hours 1compartment NA NA Human Human -DTXSID2030695 Css NA 1.672 mg/L 3compartmentss NA 50% Human Human -DTXSID2030695 Css NA 12.16 mg/L 3compartmentss NA 95% Human Human -DTXSID2030695 Css NA 1.004 mg/L PBTK NA 50% Human Human -DTXSID2030695 Css NA 7.048 mg/L PBTK NA 95% Human Human -DTXSID2030695 Clint NA 7.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2030695 Fup NA 0.0535 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2030695 Vd NA 0.2542 L/kg 1compartment NA NA Rat Human +DTXSID2030695 TK.Half.Life NA 3.811 hours 1compartment NA NA Human Human +DTXSID2030695 Css NA 1.878 mg/L 3compartmentss NA 50% Human Human +DTXSID2030695 Css NA 13.96 mg/L 3compartmentss NA 95% Human Human +DTXSID2030695 Css NA 1.134 mg/L PBTK NA 50% Human Human +DTXSID2030695 Css NA 8.216 mg/L PBTK NA 95% Human Human +DTXSID2030695 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2030695 Fup 0.0521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2030695 Vd NA 0.2911 L/kg 1compartment NA NA Rat Human DTXSID2030695 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2030695 TK.Half.Life NA 1.592 hours 1compartment NA NA Rat Human -DTXSID2030695 Css NA 0.9108 mg/L 3compartmentss NA 50% Rat Human -DTXSID2030695 Css NA 4.746 mg/L 3compartmentss NA 95% Rat Human -DTXSID2030695 Css NA 0.5104 mg/L PBTK NA 50% Rat Human -DTXSID2030695 Css NA 2.599 mg/L PBTK NA 95% Rat Human +DTXSID2030695 TK.Half.Life NA 2.081 hours 1compartment NA NA Rat Human +DTXSID2030695 Css NA 0.2328 mg/L 3compartmentss NA 50% Rat Human +DTXSID2030695 Css NA 1.229 mg/L 3compartmentss NA 95% Rat Human +DTXSID2030695 Css NA 0.136 mg/L PBTK NA 50% Rat Human +DTXSID2030695 Css NA 0.6998 mg/L PBTK NA 95% Rat Human +DTXSID2031089 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2031089 Fup NA 0.0017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2031089 Vd NA 2.971 L/kg 1compartment NA NA Human Human +DTXSID2031089 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID2031089 TK.Half.Life NA 142300 hours 1compartment NA NA Human Human +DTXSID2031089 Css NA 4732 mg/L 3compartmentss NA 50% Human Human +DTXSID2031089 Css NA 10890 mg/L 3compartmentss NA 95% Human Human +DTXSID2031089 Css NA 3246 mg/L PBTK NA 50% Human Human +DTXSID2031089 Css NA 7211 mg/L PBTK NA 95% Human Human +DTXSID2031089 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2031089 Fup NA 0.0017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2031089 Vd NA 2.221 L/kg 1compartment NA NA Rat Human +DTXSID2031089 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID2031089 TK.Half.Life NA 10830 hours 1compartment NA NA Rat Human +DTXSID2031089 Css NA 79.92 mg/L 3compartmentss NA 50% Rat Human +DTXSID2031089 Css NA 358.1 mg/L 3compartmentss NA 95% Rat Human +DTXSID2031089 Css NA 52.61 mg/L PBTK NA 50% Rat Human +DTXSID2031089 Css NA 235.5 mg/L PBTK NA 95% Rat Human DTXSID2031374 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2031374 Fup 0.98 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID2031374 Vd NA 0.8314 L/kg 1compartment NA NA Human Human +DTXSID2031374 Vd NA 0.8465 L/kg 1compartment NA NA Human Human DTXSID2031374 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2031374 TK.Half.Life NA 5.497 hours 1compartment NA NA Human Human -DTXSID2031374 Css NA 1.193 mg/L 3compartmentss NA 50% Human Human -DTXSID2031374 Css NA 5.492 mg/L 3compartmentss NA 95% Human Human -DTXSID2031374 Css NA 0.7362 mg/L PBTK NA 50% Human Human -DTXSID2031374 Css NA 3.304 mg/L PBTK NA 95% Human Human +DTXSID2031374 TK.Half.Life NA 5.603 hours 1compartment NA NA Human Human +DTXSID2031374 Css NA 1.015 mg/L 3compartmentss NA 50% Human Human +DTXSID2031374 Css NA 4.517 mg/L 3compartmentss NA 95% Human Human +DTXSID2031374 Css NA 0.623 mg/L PBTK NA 50% Human Human +DTXSID2031374 Css NA 2.773 mg/L PBTK NA 95% Human Human DTXSID2031374 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2031374 Fup 0.98 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID2031374 Vd NA 0.8593 L/kg 1compartment NA NA Rat Human +DTXSID2031374 Vd NA 0.8718 L/kg 1compartment NA NA Rat Human DTXSID2031374 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2031374 TK.Half.Life NA 1.935 hours 1compartment NA NA Rat Human -DTXSID2031374 Css NA 0.311 mg/L 3compartmentss NA 50% Rat Human -DTXSID2031374 Css NA 1.431 mg/L 3compartmentss NA 95% Rat Human -DTXSID2031374 Css NA 0.181 mg/L PBTK NA 50% Rat Human -DTXSID2031374 Css NA 0.7866 mg/L PBTK NA 95% Rat Human -DTXSID2031532 Clint NA 10.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2031532 Fup NA 0.2646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2031532 Vd NA 2.41 L/kg 1compartment NA NA Human Human -DTXSID2031532 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2031532 TK.Half.Life NA 7.977 hours 1compartment NA NA Human Human -DTXSID2031532 Css NA 0.3174 mg/L 3compartmentss NA 50% Human Human -DTXSID2031532 Css NA 1.719 mg/L 3compartmentss NA 95% Human Human -DTXSID2031532 Css NA 0.2332 mg/L PBTK NA 50% Human Human -DTXSID2031532 Css NA 1.212 mg/L PBTK NA 95% Human Human -DTXSID2031532 Clint NA 10.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2031532 Fup NA 0.2646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2031532 Vd NA 1.853 L/kg 1compartment NA NA Rat Human -DTXSID2031532 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2031532 TK.Half.Life NA 2.276 hours 1compartment NA NA Rat Human -DTXSID2031532 Css NA 0.1658 mg/L 3compartmentss NA 50% Rat Human -DTXSID2031532 Css NA 0.7068 mg/L 3compartmentss NA 95% Rat Human -DTXSID2031532 Css NA 0.1188 mg/L PBTK NA 50% Rat Human -DTXSID2031532 Css NA 0.4733 mg/L PBTK NA 95% Rat Human -DTXSID2031956 Clint NA 31.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2031956 Fup NA 0.4475 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2031956 Vd NA 1.832 L/kg 1compartment NA NA Human Human +DTXSID2031374 TK.Half.Life NA 1.962 hours 1compartment NA NA Rat Human +DTXSID2031374 Css NA 0.01813 mg/L 3compartmentss NA 50% Rat Human +DTXSID2031374 Css NA 0.1051 mg/L 3compartmentss NA 95% Rat Human +DTXSID2031374 Css NA 0.01124 mg/L PBTK NA 50% Rat Human +DTXSID2031374 Css NA 0.06598 mg/L PBTK NA 95% Rat Human +DTXSID2031956 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2031956 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2031956 Vd NA 1.536 L/kg 1compartment NA NA Human Human DTXSID2031956 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2031956 TK.Half.Life NA 1.81 hours 1compartment NA NA Human Human -DTXSID2031956 Css NA 0.0391 mg/L 3compartmentss NA 50% Human Human -DTXSID2031956 Css NA 0.2955 mg/L 3compartmentss NA 95% Human Human -DTXSID2031956 Css NA 0.03199 mg/L PBTK NA 50% Human Human -DTXSID2031956 Css NA 0.216 mg/L PBTK NA 95% Human Human -DTXSID2031956 Clint NA 31.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2031956 Fup NA 0.4475 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2031956 Vd NA 1.5 L/kg 1compartment NA NA Rat Human +DTXSID2031956 TK.Half.Life NA 1.43 hours 1compartment NA NA Human Human +DTXSID2031956 Css NA 0.03574 mg/L 3compartmentss NA 50% Human Human +DTXSID2031956 Css NA 0.3824 mg/L 3compartmentss NA 95% Human Human +DTXSID2031956 Css NA 0.03068 mg/L PBTK NA 50% Human Human +DTXSID2031956 Css NA 0.266 mg/L PBTK NA 95% Human Human +DTXSID2031956 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2031956 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2031956 Vd NA 1.326 L/kg 1compartment NA NA Rat Human DTXSID2031956 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2031956 TK.Half.Life NA 0.6789 hours 1compartment NA NA Rat Human -DTXSID2031956 Css NA 0.02102 mg/L 3compartmentss NA 50% Rat Human -DTXSID2031956 Css NA 0.1337 mg/L 3compartmentss NA 95% Rat Human -DTXSID2031956 Css NA 0.01668 mg/L PBTK NA 50% Rat Human -DTXSID2031956 Css NA 0.09411 mg/L PBTK NA 95% Rat Human -DTXSID2032005 Clint NA 2.541 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032005 Fup NA 0.0114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032005 Vd NA 2.886 L/kg 1compartment NA NA Human Human -DTXSID2032005 Days.Css NA 113 Days PBTK NA NA Human Human -DTXSID2032005 TK.Half.Life NA 483 hours 1compartment NA NA Human Human -DTXSID2032005 Css NA 22.9 mg/L 3compartmentss NA 50% Human Human -DTXSID2032005 Css NA 135.1 mg/L 3compartmentss NA 95% Human Human -DTXSID2032005 Css NA 15.47 mg/L PBTK NA 50% Human Human -DTXSID2032005 Css NA 89.27 mg/L PBTK NA 95% Human Human -DTXSID2032005 Clint NA 2.541 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032005 Fup NA 0.0114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032005 Vd NA 2.157 L/kg 1compartment NA NA Rat Human -DTXSID2032005 Days.Css NA 59 Days PBTK NA NA Rat Human -DTXSID2032005 TK.Half.Life NA 81.13 hours 1compartment NA NA Rat Human -DTXSID2032005 Css NA 12.45 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032005 Css NA 55.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032005 Css NA 8.044 mg/L PBTK NA 50% Rat Human -DTXSID2032005 Css NA 34.4 mg/L PBTK NA 95% Rat Human +DTXSID2031956 TK.Half.Life NA 0.5924 hours 1compartment NA NA Rat Human +DTXSID2031956 Css NA 0.004416 mg/L 3compartmentss NA 50% Rat Human +DTXSID2031956 Css NA 0.03881 mg/L 3compartmentss NA 95% Rat Human +DTXSID2031956 Css NA 0.00383 mg/L PBTK NA 50% Rat Human +DTXSID2031956 Css NA 0.0271 mg/L PBTK NA 95% Rat Human +DTXSID20319722 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20319722 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20319722 Vd NA 0.4785 L/kg 1compartment NA NA Human Human +DTXSID20319722 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20319722 TK.Half.Life NA 1.763 hours 1compartment NA NA Human Human +DTXSID20319722 Css NA 0.3584 mg/L 3compartmentss NA 50% Human Human +DTXSID20319722 Css NA 2.179 mg/L 3compartmentss NA 95% Human Human +DTXSID20319722 Css NA 0.2356 mg/L PBTK NA 50% Human Human +DTXSID20319722 Css NA 1.34 mg/L PBTK NA 95% Human Human +DTXSID20319722 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20319722 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20319722 Vd NA 0.4359 L/kg 1compartment NA NA Rat Human +DTXSID20319722 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20319722 TK.Half.Life NA 0.939 hours 1compartment NA NA Rat Human +DTXSID20319722 Css NA 0.02895 mg/L 3compartmentss NA 50% Rat Human +DTXSID20319722 Css NA 0.1453 mg/L 3compartmentss NA 95% Rat Human +DTXSID20319722 Css NA 0.0188 mg/L PBTK NA 50% Rat Human +DTXSID20319722 Css NA 0.08675 mg/L PBTK NA 95% Rat Human +DTXSID2032005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032005 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032005 Vd NA 3.084 L/kg 1compartment NA NA Human Human +DTXSID2032005 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID2032005 TK.Half.Life NA 85.2 hours 1compartment NA NA Human Human +DTXSID2032005 Css NA 3.325 mg/L 3compartmentss NA 50% Human Human +DTXSID2032005 Css NA 20.66 mg/L 3compartmentss NA 95% Human Human +DTXSID2032005 Css NA 2.301 mg/L PBTK NA 50% Human Human +DTXSID2032005 Css NA 14.02 mg/L PBTK NA 95% Human Human +DTXSID2032005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032005 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032005 Vd NA 2.31 L/kg 1compartment NA NA Rat Human +DTXSID2032005 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID2032005 TK.Half.Life NA 12.05 hours 1compartment NA NA Rat Human +DTXSID2032005 Css NA 0.4332 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032005 Css NA 2.332 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032005 Css NA 0.2954 mg/L PBTK NA 50% Rat Human +DTXSID2032005 Css NA 1.583 mg/L PBTK NA 95% Rat Human DTXSID2032180 Clint 2.72e-06 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID2032180 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032180 Vd NA 7.589 L/kg 1compartment NA NA Human Human -DTXSID2032180 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID2032180 TK.Half.Life NA 360300 hours 1compartment NA NA Human Human -DTXSID2032180 Css NA 3638 mg/L 3compartmentss NA 50% Human Human -DTXSID2032180 Css NA 8615 mg/L 3compartmentss NA 95% Human Human -DTXSID2032180 Css NA 3640 mg/L PBTK NA 50% Human Human -DTXSID2032180 Css NA 7923 mg/L PBTK NA 95% Human Human +DTXSID2032180 Vd NA 7.714 L/kg 1compartment NA NA Human Human +DTXSID2032180 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID2032180 TK.Half.Life NA 366200 hours 1compartment NA NA Human Human +DTXSID2032180 Css NA 3082 mg/L 3compartmentss NA 50% Human Human +DTXSID2032180 Css NA 7533 mg/L 3compartmentss NA 95% Human Human +DTXSID2032180 Css NA 3128 mg/L PBTK NA 50% Human Human +DTXSID2032180 Css NA 6992 mg/L PBTK NA 95% Human Human DTXSID2032180 Clint 2.72e-06 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID2032180 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032180 Vd NA 5.903 L/kg 1compartment NA NA Rat Human -DTXSID2032180 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID2032180 TK.Half.Life NA 23200 hours 1compartment NA NA Rat Human -DTXSID2032180 Css NA 986.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032180 Css NA 1513 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032180 Css NA 980.3 mg/L PBTK NA 50% Rat Human -DTXSID2032180 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID2032342 Clint NA 3.372 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032342 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032342 Vd NA 2.565 L/kg 1compartment NA NA Human Human -DTXSID2032342 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID2032342 TK.Half.Life NA 91.65 hours 1compartment NA NA Human Human -DTXSID2032342 Css NA 4.95 mg/L 3compartmentss NA 50% Human Human -DTXSID2032342 Css NA 25.22 mg/L 3compartmentss NA 95% Human Human -DTXSID2032342 Css NA 3.348 mg/L PBTK NA 50% Human Human -DTXSID2032342 Css NA 16.35 mg/L PBTK NA 95% Human Human -DTXSID2032342 Clint NA 3.372 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032342 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032342 Vd NA 1.923 L/kg 1compartment NA NA Rat Human -DTXSID2032342 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID2032342 TK.Half.Life NA 20.06 hours 1compartment NA NA Rat Human -DTXSID2032342 Css NA 2.536 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032342 Css NA 9.202 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032342 Css NA 1.638 mg/L PBTK NA 50% Rat Human -DTXSID2032342 Css NA 5.625 mg/L PBTK NA 95% Rat Human +DTXSID2032180 Vd NA 6.003 L/kg 1compartment NA NA Rat Human +DTXSID2032180 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID2032180 TK.Half.Life NA 23580 hours 1compartment NA NA Rat Human +DTXSID2032180 Css NA 71.34 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032180 Css NA 288.1 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032180 Css NA 73.31 mg/L PBTK NA 50% Rat Human +DTXSID2032180 Css NA 268.5 mg/L PBTK NA 95% Rat Human +DTXSID2032342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032342 Fup 0.0481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032342 Vd NA 2.461 L/kg 1compartment NA NA Human Human +DTXSID2032342 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2032342 TK.Half.Life NA 17.46 hours 1compartment NA NA Human Human +DTXSID2032342 Css NA 0.9074 mg/L 3compartmentss NA 50% Human Human +DTXSID2032342 Css NA 6.206 mg/L 3compartmentss NA 95% Human Human +DTXSID2032342 Css NA 0.609 mg/L PBTK NA 50% Human Human +DTXSID2032342 Css NA 3.977 mg/L PBTK NA 95% Human Human +DTXSID2032342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032342 Fup 0.0481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032342 Vd NA 1.843 L/kg 1compartment NA NA Rat Human +DTXSID2032342 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2032342 TK.Half.Life NA 4.527 hours 1compartment NA NA Rat Human +DTXSID2032342 Css NA 0.1162 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032342 Css NA 0.6434 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032342 Css NA 0.07686 mg/L PBTK NA 50% Rat Human +DTXSID2032342 Css NA 0.4113 mg/L PBTK NA 95% Rat Human DTXSID2032344 Clint 617 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2032344 Fup 0.00394 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2032344 Vd NA 2.077 L/kg 1compartment NA NA Human Human DTXSID2032344 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2032344 TK.Half.Life NA 3.637 hours 1compartment NA NA Human Human -DTXSID2032344 Css NA 0.1071 mg/L 3compartmentss NA 50% Human Human -DTXSID2032344 Css NA 0.7969 mg/L 3compartmentss NA 95% Human Human -DTXSID2032344 Css NA 0.06992 mg/L PBTK NA 50% Human Human -DTXSID2032344 Css NA 0.5034 mg/L PBTK NA 95% Human Human +DTXSID2032344 Css NA 0.1026 mg/L 3compartmentss NA 50% Human Human +DTXSID2032344 Css NA 0.7912 mg/L 3compartmentss NA 95% Human Human +DTXSID2032344 Css NA 0.06678 mg/L PBTK NA 50% Human Human +DTXSID2032344 Css NA 0.5029 mg/L PBTK NA 95% Human Human DTXSID2032344 Clint 617 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2032344 Fup 0.00394 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2032344 Vd NA 1.536 L/kg 1compartment NA NA Rat Human DTXSID2032344 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2032344 TK.Half.Life NA 1.154 hours 1compartment NA NA Rat Human -DTXSID2032344 Css NA 0.0618 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032344 Css NA 0.3592 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032344 Css NA 0.03817 mg/L PBTK NA 50% Rat Human -DTXSID2032344 Css NA 0.215 mg/L PBTK NA 95% Rat Human +DTXSID2032344 Css NA 0.01368 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032344 Css NA 0.08341 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032344 Css NA 0.008761 mg/L PBTK NA 50% Rat Human +DTXSID2032344 Css NA 0.05187 mg/L PBTK NA 95% Rat Human DTXSID2032348 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2032348 Fup 2.44e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2032348 Vd NA 0.1601 L/kg 1compartment NA NA Human Human -DTXSID2032348 Days.Css NA 2873 Days PBTK NA NA Human Human -DTXSID2032348 TK.Half.Life NA 10360 hours 1compartment NA NA Human Human -DTXSID2032348 Css NA 4762 mg/L 3compartmentss NA 50% Human Human -DTXSID2032348 Css NA 13700 mg/L 3compartmentss NA 95% Human Human -DTXSID2032348 Css NA 2841 mg/L PBTK NA 50% Human Human -DTXSID2032348 Css NA 7740 mg/L PBTK NA 95% Human Human +DTXSID2032348 Vd NA 0.1603 L/kg 1compartment NA NA Human Human +DTXSID2032348 Days.Css NA 2860 Days PBTK NA NA Human Human +DTXSID2032348 TK.Half.Life NA 10370 hours 1compartment NA NA Human Human +DTXSID2032348 Css NA 3740 mg/L 3compartmentss NA 50% Human Human +DTXSID2032348 Css NA 11470 mg/L 3compartmentss NA 95% Human Human +DTXSID2032348 Css NA 2190 mg/L PBTK NA 50% Human Human +DTXSID2032348 Css NA 6546 mg/L PBTK NA 95% Human Human DTXSID2032348 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2032348 Fup 2.44e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2032348 Vd NA 0.1584 L/kg 1compartment NA NA Rat Human -DTXSID2032348 Days.Css NA 961 Days PBTK NA NA Rat Human +DTXSID2032348 Days.Css NA 962 Days PBTK NA NA Rat Human DTXSID2032348 TK.Half.Life NA 3492 hours 1compartment NA NA Rat Human -DTXSID2032348 Css NA 1784 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032348 Css NA 2453 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032348 Css NA 963.9 mg/L PBTK NA 50% Rat Human -DTXSID2032348 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID2032348 Css NA 44.49 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032348 Css NA 316.6 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032348 Css NA 24.15 mg/L PBTK NA 50% Rat Human +DTXSID2032348 Css NA 175 mg/L PBTK NA 95% Rat Human DTXSID2032390 Clint 3.788 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032390 Fup 0.03671 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032390 Vd NA 2.068 L/kg 1compartment NA NA Human Human DTXSID2032390 Days.Css NA 11 Days PBTK NA NA Human Human DTXSID2032390 TK.Half.Life NA 68.16 hours 1compartment NA NA Human Human -DTXSID2032390 Css NA 5.052 mg/L 3compartmentss NA 50% Human Human -DTXSID2032390 Css NA 28.84 mg/L 3compartmentss NA 95% Human Human -DTXSID2032390 Css NA 3.313 mg/L PBTK NA 50% Human Human -DTXSID2032390 Css NA 18.02 mg/L PBTK NA 95% Human Human +DTXSID2032390 Css NA 4.315 mg/L 3compartmentss NA 50% Human Human +DTXSID2032390 Css NA 24.54 mg/L 3compartmentss NA 95% Human Human +DTXSID2032390 Css NA 3.225 mg/L PBTK NA 50% Human Human +DTXSID2032390 Css NA 18.35 mg/L PBTK NA 95% Human Human DTXSID2032390 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID2032390 Fup 0.0276 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID2032390 Vd NA 1.4 L/kg 1compartment NA NA Rat Rat +DTXSID2032390 Vd 2.7 1.4 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID2032390 Days.Css NA 47 Days PBTK NA NA Rat Rat -DTXSID2032390 TK.Half.Life NA 132.7 hours 1compartment NA NA Rat Rat -DTXSID2032390 Css NA 16.59 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2032390 Css NA 67.05 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2032390 Css NA 10.45 mg/L PBTK NA 50% Rat Rat -DTXSID2032390 Css NA 37.88 mg/L PBTK NA 95% Rat Rat +DTXSID2032390 TK.Half.Life 0.54 132.7 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID2032390 Css 0.012 3.144 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID2032390 Css 0.012 11.43 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID2032390 Css 0.012 2.435 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID2032390 Css 0.012 8.856 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID2032392 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID2032392 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032392 Vd NA 2.743 L/kg 1compartment NA NA Human Human -DTXSID2032392 Days.Css NA 1655 Days PBTK NA NA Human Human -DTXSID2032392 TK.Half.Life NA 6080 hours 1compartment NA NA Human Human -DTXSID2032392 Css NA 289.9 mg/L 3compartmentss NA 50% Human Human -DTXSID2032392 Css NA 916.9 mg/L 3compartmentss NA 95% Human Human -DTXSID2032392 Css NA 195.3 mg/L PBTK NA 50% Human Human -DTXSID2032392 Css NA 572.1 mg/L PBTK NA 95% Human Human +DTXSID2032392 Fup 0.00573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032392 Vd NA 2.288 L/kg 1compartment NA NA Human Human +DTXSID2032392 Days.Css NA 1821 Days PBTK NA NA Human Human +DTXSID2032392 TK.Half.Life NA 6691 hours 1compartment NA NA Human Human +DTXSID2032392 Css NA 401.8 mg/L 3compartmentss NA 50% Human Human +DTXSID2032392 Css NA 1703 mg/L 3compartmentss NA 95% Human Human +DTXSID2032392 Css NA 261.4 mg/L PBTK NA 50% Human Human +DTXSID2032392 Css NA 1027 mg/L PBTK NA 95% Human Human DTXSID2032392 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID2032392 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032392 Vd NA 2.048 L/kg 1compartment NA NA Rat Human -DTXSID2032392 Days.Css NA 421 Days PBTK NA NA Rat Human -DTXSID2032392 TK.Half.Life NA 591.9 hours 1compartment NA NA Rat Human -DTXSID2032392 Css NA 78.83 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032392 Css NA 215.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032392 Css NA 50.38 mg/L PBTK NA 50% Rat Human -DTXSID2032392 Css NA 125 mg/L PBTK NA 95% Rat Human +DTXSID2032392 Fup 0.00573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032392 Vd NA 1.698 L/kg 1compartment NA NA Rat Human +DTXSID2032392 Days.Css NA 458 Days PBTK NA NA Rat Human +DTXSID2032392 TK.Half.Life NA 901.2 hours 1compartment NA NA Rat Human +DTXSID2032392 Css NA 25.86 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032392 Css NA 86.66 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032392 Css NA 16.36 mg/L PBTK NA 50% Rat Human +DTXSID2032392 Css NA 50.55 mg/L PBTK NA 95% Rat Human DTXSID2032398 Clint 37.05 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032398 Fup 0.003583 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032398 Vd NA 1.327 L/kg 1compartment NA NA Human Human DTXSID2032398 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID2032398 TK.Half.Life NA 23.2 hours 1compartment NA NA Human Human -DTXSID2032398 Css NA 2.912 mg/L 3compartmentss NA 50% Human Human -DTXSID2032398 Css NA 23.79 mg/L 3compartmentss NA 95% Human Human -DTXSID2032398 Css NA 1.84 mg/L PBTK NA 50% Human Human -DTXSID2032398 Css NA 14.62 mg/L PBTK NA 95% Human Human +DTXSID2032398 Css NA 2.813 mg/L 3compartmentss NA 50% Human Human +DTXSID2032398 Css NA 21.82 mg/L 3compartmentss NA 95% Human Human +DTXSID2032398 Css NA 1.81 mg/L PBTK NA 50% Human Human +DTXSID2032398 Css NA 14.04 mg/L PBTK NA 95% Human Human DTXSID2032398 Clint 37.44 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID2032398 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID2032398 Css NA 1.303 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2032398 Css NA 9.93 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2032421 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032421 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032421 Vd NA 0.4096 L/kg 1compartment NA NA Human Human -DTXSID2032421 Days.Css NA 131 Days PBTK NA NA Human Human -DTXSID2032421 TK.Half.Life NA 489.9 hours 1compartment NA NA Human Human -DTXSID2032421 Css NA 203.6 mg/L 3compartmentss NA 50% Human Human -DTXSID2032421 Css NA 1234 mg/L 3compartmentss NA 95% Human Human -DTXSID2032421 Css NA 123 mg/L PBTK NA 50% Human Human -DTXSID2032421 Css NA 716.6 mg/L PBTK NA 95% Human Human -DTXSID2032421 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032421 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032421 Vd NA 0.3495 L/kg 1compartment NA NA Rat Human -DTXSID2032421 Days.Css NA 34 Days PBTK NA NA Rat Human -DTXSID2032421 TK.Half.Life NA 140.7 hours 1compartment NA NA Rat Human -DTXSID2032421 Css NA 57.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032421 Css NA 303 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032421 Css NA 32.12 mg/L PBTK NA 50% Rat Human -DTXSID2032421 Css NA 164.9 mg/L PBTK NA 95% Rat Human +DTXSID2032398 Css NA 0.2674 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2032398 Css NA 1.972 mg/L 3compartmentss NA 95% Rat Rat DTXSID2032500 Clint 19.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2032500 Fup 0.00839 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2032500 Vd NA 0.2202 L/kg 1compartment NA NA Human Human DTXSID2032500 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2032500 TK.Half.Life NA 5.123 hours 1compartment NA NA Human Human -DTXSID2032500 Css NA 2.255 mg/L 3compartmentss NA 50% Human Human -DTXSID2032500 Css NA 18.41 mg/L 3compartmentss NA 95% Human Human -DTXSID2032500 Css NA 1.55 mg/L PBTK NA 50% Human Human -DTXSID2032500 Css NA 11.45 mg/L PBTK NA 95% Human Human +DTXSID2032500 Css NA 2.362 mg/L 3compartmentss NA 50% Human Human +DTXSID2032500 Css NA 18.06 mg/L 3compartmentss NA 95% Human Human +DTXSID2032500 Css NA 1.519 mg/L PBTK NA 50% Human Human +DTXSID2032500 Css NA 11.62 mg/L PBTK NA 95% Human Human DTXSID2032500 Clint 20.62 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID2032500 Fup 0.009457 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID2032500 Vd NA 0.2125 L/kg 1compartment NA NA Rat Rat DTXSID2032500 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID2032500 TK.Half.Life NA 2.818 hours 1compartment NA NA Rat Rat -DTXSID2032500 Css NA 1.894 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2032500 Css NA 15.74 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2032500 Css NA 1.144 mg/L PBTK NA 50% Rat Rat -DTXSID2032500 Css NA 8.85 mg/L PBTK NA 95% Rat Rat +DTXSID2032500 Css NA 0.4001 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2032500 Css NA 3.151 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2032500 Css NA 0.2666 mg/L PBTK NA 50% Rat Rat +DTXSID2032500 Css NA 2.099 mg/L PBTK NA 95% Rat Rat DTXSID2032502 Clint 14.47 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032502 Fup 0.3292 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032502 Vd NA 1.067 L/kg 1compartment NA NA Human Human DTXSID2032502 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2032502 TK.Half.Life NA 1.397 hours 1compartment NA NA Human Human -DTXSID2032502 Css NA 0.07303 mg/L 3compartmentss NA 50% Human Human -DTXSID2032502 Css NA 0.5771 mg/L 3compartmentss NA 95% Human Human -DTXSID2032502 Css NA 0.06946 mg/L PBTK NA 50% Human Human -DTXSID2032502 Css NA 0.4481 mg/L PBTK NA 95% Human Human +DTXSID2032502 Css NA 0.05828 mg/L 3compartmentss NA 50% Human Human +DTXSID2032502 Css NA 0.5212 mg/L 3compartmentss NA 95% Human Human +DTXSID2032502 Css NA 0.05606 mg/L PBTK NA 50% Human Human +DTXSID2032502 Css NA 0.4055 mg/L PBTK NA 95% Human Human DTXSID2032502 Clint 14.47 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2032502 Fup 0.3292 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2032502 Vd NA 1.05 L/kg 1compartment NA NA Rat Human DTXSID2032502 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2032502 TK.Half.Life NA 0.7728 hours 1compartment NA NA Rat Human -DTXSID2032502 Css NA 0.03795 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032502 Css NA 0.2377 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032502 Css NA 0.03562 mg/L PBTK NA 50% Rat Human -DTXSID2032502 Css NA 0.1768 mg/L PBTK NA 95% Rat Human +DTXSID2032502 Css NA 0.00266 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032502 Css NA 0.02464 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032502 Css NA 0.002601 mg/L PBTK NA 50% Rat Human +DTXSID2032502 Css NA 0.01898 mg/L PBTK NA 95% Rat Human DTXSID2032550 Clint 16.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2032550 Fup 0.0046 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2032550 Vd NA 2.653 L/kg 1compartment NA NA Human Human DTXSID2032550 Days.Css NA 13 Days PBTK NA NA Human Human DTXSID2032550 TK.Half.Life NA 84.86 hours 1compartment NA NA Human Human -DTXSID2032550 Css NA 3.955 mg/L 3compartmentss NA 50% Human Human -DTXSID2032550 Css NA 26 mg/L 3compartmentss NA 95% Human Human -DTXSID2032550 Css NA 2.654 mg/L PBTK NA 50% Human Human -DTXSID2032550 Css NA 16.82 mg/L PBTK NA 95% Human Human +DTXSID2032550 Css NA 3.815 mg/L 3compartmentss NA 50% Human Human +DTXSID2032550 Css NA 25.4 mg/L 3compartmentss NA 95% Human Human +DTXSID2032550 Css NA 2.555 mg/L PBTK NA 50% Human Human +DTXSID2032550 Css NA 16.68 mg/L PBTK NA 95% Human Human DTXSID2032550 Clint 16.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2032550 Fup 0.0046 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2032550 Vd NA 1.978 L/kg 1compartment NA NA Rat Human DTXSID2032550 Days.Css NA 7 Days PBTK NA NA Rat Human DTXSID2032550 TK.Half.Life NA 18.36 hours 1compartment NA NA Rat Human -DTXSID2032550 Css NA 2.235 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032550 Css NA 11.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032550 Css NA 1.433 mg/L PBTK NA 50% Rat Human -DTXSID2032550 Css NA 7.17 mg/L PBTK NA 95% Rat Human +DTXSID2032550 Css NA 0.5004 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032550 Css NA 2.766 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032550 Css NA 0.3324 mg/L PBTK NA 50% Rat Human +DTXSID2032550 Css NA 1.788 mg/L PBTK NA 95% Rat Human DTXSID2032552 Clint 29 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032552 Fup 0.1375 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032552 Vd NA 2.378 L/kg 1compartment NA NA Human Human DTXSID2032552 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2032552 TK.Half.Life NA 5.879 hours 1compartment NA NA Human Human -DTXSID2032552 Css NA 0.2556 mg/L 3compartmentss NA 50% Human Human -DTXSID2032552 Css NA 1.758 mg/L 3compartmentss NA 95% Human Human -DTXSID2032552 Css NA 0.1744 mg/L PBTK NA 50% Human Human -DTXSID2032552 Css NA 1.155 mg/L PBTK NA 95% Human Human +DTXSID2032552 Css NA 0.2001 mg/L 3compartmentss NA 50% Human Human +DTXSID2032552 Css NA 1.323 mg/L 3compartmentss NA 95% Human Human +DTXSID2032552 Css NA 0.1711 mg/L PBTK NA 50% Human Human +DTXSID2032552 Css NA 1.132 mg/L PBTK NA 95% Human Human DTXSID2032552 Clint 40.92 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID2032552 Fup 0.2007 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID2032552 Vd NA 1.968 L/kg 1compartment NA NA Rat Rat +DTXSID2032552 Vd 2.3 1.968 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID2032552 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID2032552 TK.Half.Life NA 1.265 hours 1compartment NA NA Rat Rat -DTXSID2032552 Css NA 0.08578 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2032552 Css NA 0.4148 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2032552 Css NA 0.05407 mg/L PBTK NA 50% Rat Rat -DTXSID2032552 Css NA 0.2559 mg/L PBTK NA 95% Rat Rat +DTXSID2032552 TK.Half.Life 0.046 1.265 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID2032552 Css 0.0012 0.0141 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID2032552 Css 0.0012 0.07177 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID2032552 Css 0.0012 0.0125 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID2032552 Css 0.0012 0.06361 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID2032554 Clint 432 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2032554 Fup NA 0.0151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032554 Vd NA 2.965 L/kg 1compartment NA NA Human Human +DTXSID2032554 Fup 0.0475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032554 Vd NA 3.084 L/kg 1compartment NA NA Human Human DTXSID2032554 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2032554 TK.Half.Life NA 5.458 hours 1compartment NA NA Human Human -DTXSID2032554 Css NA 0.1349 mg/L 3compartmentss NA 50% Human Human -DTXSID2032554 Css NA 0.9159 mg/L 3compartmentss NA 95% Human Human -DTXSID2032554 Css NA 0.09254 mg/L PBTK NA 50% Human Human -DTXSID2032554 Css NA 0.6026 mg/L PBTK NA 95% Human Human +DTXSID2032554 TK.Half.Life NA 5.466 hours 1compartment NA NA Human Human +DTXSID2032554 Css NA 0.1156 mg/L 3compartmentss NA 50% Human Human +DTXSID2032554 Css NA 0.806 mg/L 3compartmentss NA 95% Human Human +DTXSID2032554 Css NA 0.07988 mg/L PBTK NA 50% Human Human +DTXSID2032554 Css NA 0.5413 mg/L PBTK NA 95% Human Human DTXSID2032554 Clint 432 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2032554 Fup NA 0.0151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032554 Vd NA 2.218 L/kg 1compartment NA NA Rat Human +DTXSID2032554 Fup 0.0475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032554 Vd NA 2.312 L/kg 1compartment NA NA Rat Human DTXSID2032554 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2032554 TK.Half.Life NA 1.282 hours 1compartment NA NA Rat Human -DTXSID2032554 Css NA 0.07786 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032554 Css NA 0.4196 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032554 Css NA 0.05077 mg/L PBTK NA 50% Rat Human -DTXSID2032554 Css NA 0.2652 mg/L PBTK NA 95% Rat Human -DTXSID2032558 Clint NA 712.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032558 Fup NA 0.0221 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032558 Vd NA 0.8185 L/kg 1compartment NA NA Human Human +DTXSID2032554 TK.Half.Life NA 1.232 hours 1compartment NA NA Rat Human +DTXSID2032554 Css NA 0.01509 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032554 Css NA 0.08998 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032554 Css NA 0.01038 mg/L PBTK NA 50% Rat Human +DTXSID2032554 Css NA 0.06104 mg/L PBTK NA 95% Rat Human +DTXSID2032556 Clint 645 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID2032556 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032556 Vd NA 2.796 L/kg 1compartment NA NA Human Human +DTXSID2032556 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2032556 TK.Half.Life NA 2.751 hours 1compartment NA NA Human Human +DTXSID2032556 Css NA 0.02078 mg/L 3compartmentss NA 50% Human Human +DTXSID2032556 Css NA 0.161 mg/L 3compartmentss NA 95% Human Human +DTXSID2032556 Css NA 0.01445 mg/L PBTK NA 50% Human Human +DTXSID2032556 Css NA 0.1076 mg/L PBTK NA 95% Human Human +DTXSID2032556 Clint 645 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID2032556 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032556 Vd NA 2.103 L/kg 1compartment NA NA Rat Human +DTXSID2032556 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2032556 TK.Half.Life NA 0.8377 hours 1compartment NA NA Rat Human +DTXSID2032556 Css NA 0.002787 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032556 Css NA 0.01805 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032556 Css NA 0.001922 mg/L PBTK NA 50% Rat Human +DTXSID2032556 Css NA 0.01208 mg/L PBTK NA 95% Rat Human +DTXSID2032558 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032558 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032558 Vd NA 0.9185 L/kg 1compartment NA NA Human Human DTXSID2032558 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2032558 TK.Half.Life NA 0.9538 hours 1compartment NA NA Human Human -DTXSID2032558 Css NA 0.04333 mg/L 3compartmentss NA 50% Human Human -DTXSID2032558 Css NA 0.4208 mg/L 3compartmentss NA 95% Human Human -DTXSID2032558 Css NA 0.02606 mg/L PBTK NA 50% Human Human -DTXSID2032558 Css NA 0.2495 mg/L PBTK NA 95% Human Human -DTXSID2032558 Clint NA 712.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032558 Fup NA 0.0221 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032558 Vd NA 0.6129 L/kg 1compartment NA NA Rat Human +DTXSID2032558 TK.Half.Life NA 6.261 hours 1compartment NA NA Human Human +DTXSID2032558 Css NA 1.072 mg/L 3compartmentss NA 50% Human Human +DTXSID2032558 Css NA 10.06 mg/L 3compartmentss NA 95% Human Human +DTXSID2032558 Css NA 0.6526 mg/L PBTK NA 50% Human Human +DTXSID2032558 Css NA 5.936 mg/L PBTK NA 95% Human Human +DTXSID2032558 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032558 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032558 Vd NA 0.6878 L/kg 1compartment NA NA Rat Human DTXSID2032558 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2032558 TK.Half.Life NA 0.3413 hours 1compartment NA NA Rat Human -DTXSID2032558 Css NA 0.02427 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032558 Css NA 0.2111 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032558 Css NA 0.01374 mg/L PBTK NA 50% Rat Human -DTXSID2032558 Css NA 0.1167 mg/L PBTK NA 95% Rat Human -DTXSID2032631 Clint NA 1.681 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032631 Fup NA 0.2538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032631 Vd NA 0.5603 L/kg 1compartment NA NA Human Human +DTXSID2032558 TK.Half.Life NA 2.778 hours 1compartment NA NA Rat Human +DTXSID2032558 Css NA 0.1381 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032558 Css NA 1.028 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032558 Css NA 0.08178 mg/L PBTK NA 50% Rat Human +DTXSID2032558 Css NA 0.5882 mg/L PBTK NA 95% Rat Human +DTXSID2032631 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032631 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032631 Vd NA 0.9036 L/kg 1compartment NA NA Human Human DTXSID2032631 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2032631 TK.Half.Life NA 4.028 hours 1compartment NA NA Human Human -DTXSID2032631 Css NA 0.8162 mg/L 3compartmentss NA 50% Human Human -DTXSID2032631 Css NA 3.948 mg/L 3compartmentss NA 95% Human Human -DTXSID2032631 Css NA 0.5664 mg/L PBTK NA 50% Human Human -DTXSID2032631 Css NA 2.509 mg/L PBTK NA 95% Human Human -DTXSID2032631 Clint NA 1.681 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032631 Fup NA 0.2538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032631 Vd NA 0.531 L/kg 1compartment NA NA Rat Human +DTXSID2032631 TK.Half.Life NA 1.369 hours 1compartment NA NA Human Human +DTXSID2032631 Css NA 0.1112 mg/L 3compartmentss NA 50% Human Human +DTXSID2032631 Css NA 1.01 mg/L 3compartmentss NA 95% Human Human +DTXSID2032631 Css NA 0.09118 mg/L PBTK NA 50% Human Human +DTXSID2032631 Css NA 0.68 mg/L PBTK NA 95% Human Human +DTXSID2032631 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032631 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032631 Vd NA 0.8617 L/kg 1compartment NA NA Rat Human DTXSID2032631 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2032631 TK.Half.Life NA 2.016 hours 1compartment NA NA Rat Human -DTXSID2032631 Css NA 0.363 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032631 Css NA 1.277 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032631 Css NA 0.2398 mg/L PBTK NA 50% Rat Human -DTXSID2032631 Css NA 0.7531 mg/L PBTK NA 95% Rat Human +DTXSID2032631 TK.Half.Life NA 0.7014 hours 1compartment NA NA Rat Human +DTXSID2032631 Css NA 0.01242 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032631 Css NA 0.09773 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032631 Css NA 0.01032 mg/L PBTK NA 50% Rat Human +DTXSID2032631 Css NA 0.06124 mg/L PBTK NA 95% Rat Human DTXSID2032637 Clint 8.611 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032637 Fup 0.9946 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2032637 Vd NA 0.9032 L/kg 1compartment NA NA Human Human DTXSID2032637 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2032637 TK.Half.Life NA 0.8136 hours 1compartment NA NA Human Human -DTXSID2032637 Css NA 0.05903 mg/L 3compartmentss NA 50% Human Human -DTXSID2032637 Css NA 0.5496 mg/L 3compartmentss NA 95% Human Human -DTXSID2032637 Css NA 0.05001 mg/L PBTK NA 50% Human Human -DTXSID2032637 Css NA 0.3908 mg/L PBTK NA 95% Human Human +DTXSID2032637 Css NA 0.05522 mg/L 3compartmentss NA 50% Human Human +DTXSID2032637 Css NA 0.5159 mg/L 3compartmentss NA 95% Human Human +DTXSID2032637 Css NA 0.04656 mg/L PBTK NA 50% Human Human +DTXSID2032637 Css NA 0.376 mg/L PBTK NA 95% Human Human DTXSID2032637 Clint 8.611 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2032637 Fup 0.9946 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2032637 Vd NA 0.9223 L/kg 1compartment NA NA Rat Human DTXSID2032637 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2032637 TK.Half.Life NA 0.4232 hours 1compartment NA NA Rat Human -DTXSID2032637 Css NA 0.02826 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032637 Css NA 0.2101 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032637 Css NA 0.02383 mg/L PBTK NA 50% Rat Human -DTXSID2032637 Css NA 0.1388 mg/L PBTK NA 95% Rat Human -DTXSID2032639 Clint NA 16.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032639 Fup NA 0.0091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032639 Vd NA 0.5389 L/kg 1compartment NA NA Human Human -DTXSID2032639 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2032639 TK.Half.Life NA 12.3 hours 1compartment NA NA Human Human -DTXSID2032639 Css NA 4.122 mg/L 3compartmentss NA 50% Human Human -DTXSID2032639 Css NA 38.17 mg/L 3compartmentss NA 95% Human Human -DTXSID2032639 Css NA 2.428 mg/L PBTK NA 50% Human Human -DTXSID2032639 Css NA 22.41 mg/L PBTK NA 95% Human Human -DTXSID2032639 Clint NA 16.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032639 Fup NA 0.0091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032639 Vd NA 0.4091 L/kg 1compartment NA NA Rat Human +DTXSID2032637 Css NA 0.006079 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032637 Css NA 0.04766 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032637 Css NA 0.005309 mg/L PBTK NA 50% Rat Human +DTXSID2032637 Css NA 0.03292 mg/L PBTK NA 95% Rat Human +DTXSID2032639 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032639 Fup 0.0561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032639 Vd NA 1.642 L/kg 1compartment NA NA Human Human +DTXSID2032639 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2032639 TK.Half.Life NA 7.329 hours 1compartment NA NA Human Human +DTXSID2032639 Css NA 0.5745 mg/L 3compartmentss NA 50% Human Human +DTXSID2032639 Css NA 4.218 mg/L 3compartmentss NA 95% Human Human +DTXSID2032639 Css NA 0.3722 mg/L PBTK NA 50% Human Human +DTXSID2032639 Css NA 2.604 mg/L PBTK NA 95% Human Human +DTXSID2032639 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032639 Fup 0.0561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032639 Vd NA 1.235 L/kg 1compartment NA NA Rat Human DTXSID2032639 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2032639 TK.Half.Life NA 6.038 hours 1compartment NA NA Rat Human -DTXSID2032639 Css NA 2.32 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032639 Css NA 18.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032639 Css NA 1.28 mg/L PBTK NA 50% Rat Human -DTXSID2032639 Css NA 10.13 mg/L PBTK NA 95% Rat Human +DTXSID2032639 TK.Half.Life NA 2.713 hours 1compartment NA NA Rat Human +DTXSID2032639 Css NA 0.07371 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032639 Css NA 0.4478 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032639 Css NA 0.04656 mg/L PBTK NA 50% Rat Human +DTXSID2032639 Css NA 0.2699 mg/L PBTK NA 95% Rat Human DTXSID2032683 Clint 4.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2032683 Fup 0.674 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2032683 Vd NA 0.7695 L/kg 1compartment NA NA Human Human DTXSID2032683 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2032683 TK.Half.Life NA 1.224 hours 1compartment NA NA Human Human -DTXSID2032683 Css NA 0.1101 mg/L 3compartmentss NA 50% Human Human -DTXSID2032683 Css NA 0.5151 mg/L 3compartmentss NA 95% Human Human -DTXSID2032683 Css NA 0.09184 mg/L PBTK NA 50% Human Human -DTXSID2032683 Css NA 0.3898 mg/L PBTK NA 95% Human Human +DTXSID2032683 Css NA 0.1038 mg/L 3compartmentss NA 50% Human Human +DTXSID2032683 Css NA 0.5036 mg/L 3compartmentss NA 95% Human Human +DTXSID2032683 Css NA 0.08632 mg/L PBTK NA 50% Human Human +DTXSID2032683 Css NA 0.3864 mg/L PBTK NA 95% Human Human DTXSID2032683 Clint 4.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2032683 Fup 0.674 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2032683 Vd NA 0.7732 L/kg 1compartment NA NA Rat Human DTXSID2032683 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2032683 TK.Half.Life NA 0.6614 hours 1compartment NA NA Rat Human -DTXSID2032683 Css NA 0.05216 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032683 Css NA 0.1752 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032683 Css NA 0.04264 mg/L PBTK NA 50% Rat Human -DTXSID2032683 Css NA 0.1304 mg/L PBTK NA 95% Rat Human -DTXSID2032891 Clint NA 3.474 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032891 Fup NA 0.0957 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2032891 Vd NA 2.453 L/kg 1compartment NA NA Human Human -DTXSID2032891 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID2032891 TK.Half.Life NA 52.04 hours 1compartment NA NA Human Human -DTXSID2032891 Css NA 2.872 mg/L 3compartmentss NA 50% Human Human -DTXSID2032891 Css NA 14.38 mg/L 3compartmentss NA 95% Human Human -DTXSID2032891 Css NA 1.975 mg/L PBTK NA 50% Human Human -DTXSID2032891 Css NA 9.408 mg/L PBTK NA 95% Human Human -DTXSID2032891 Clint NA 3.474 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032891 Fup NA 0.0957 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2032891 Vd NA 1.848 L/kg 1compartment NA NA Rat Human -DTXSID2032891 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2032891 TK.Half.Life NA 12.42 hours 1compartment NA NA Rat Human -DTXSID2032891 Css NA 1.446 mg/L 3compartmentss NA 50% Rat Human -DTXSID2032891 Css NA 5.149 mg/L 3compartmentss NA 95% Rat Human -DTXSID2032891 Css NA 0.9431 mg/L PBTK NA 50% Rat Human -DTXSID2032891 Css NA 3.173 mg/L PBTK NA 95% Rat Human +DTXSID2032683 Css NA 0.01146 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032683 Css NA 0.03962 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032683 Css NA 0.009758 mg/L PBTK NA 50% Rat Human +DTXSID2032683 Css NA 0.03063 mg/L PBTK NA 95% Rat Human +DTXSID2032891 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032891 Fup 0.0287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2032891 Vd NA 1.539 L/kg 1compartment NA NA Human Human +DTXSID2032891 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2032891 TK.Half.Life NA 10.97 hours 1compartment NA NA Human Human +DTXSID2032891 Css NA 1.051 mg/L 3compartmentss NA 50% Human Human +DTXSID2032891 Css NA 9.072 mg/L 3compartmentss NA 95% Human Human +DTXSID2032891 Css NA 0.6676 mg/L PBTK NA 50% Human Human +DTXSID2032891 Css NA 5.476 mg/L PBTK NA 95% Human Human +DTXSID2032891 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032891 Fup 0.0287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2032891 Vd NA 1.146 L/kg 1compartment NA NA Rat Human +DTXSID2032891 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2032891 TK.Half.Life NA 4.176 hours 1compartment NA NA Rat Human +DTXSID2032891 Css NA 0.1379 mg/L 3compartmentss NA 50% Rat Human +DTXSID2032891 Css NA 0.9534 mg/L 3compartmentss NA 95% Rat Human +DTXSID2032891 Css NA 0.08472 mg/L PBTK NA 50% Rat Human +DTXSID2032891 Css NA 0.5612 mg/L PBTK NA 95% Rat Human DTXSID2033281 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2033281 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2033281 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID2033281 Vd NA 0.3275 L/kg 1compartment NA NA Human Human DTXSID2033281 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2033281 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID2033281 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID2033281 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID2033281 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID2033281 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID2033281 TK.Half.Life NA 6.558 hours 1compartment NA NA Human Human +DTXSID2033281 Css NA 2.057 mg/L 3compartmentss NA 50% Human Human +DTXSID2033281 Css NA 8.591 mg/L 3compartmentss NA 95% Human Human +DTXSID2033281 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID2033281 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID2033281 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2033281 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2033281 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID2033281 Vd NA 0.3456 L/kg 1compartment NA NA Rat Human DTXSID2033281 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2033281 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID2033281 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID2033281 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID2033281 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID2033281 Css NA 1.313 mg/L PBTK NA 95% Rat Human +DTXSID2033281 TK.Half.Life NA 2.358 hours 1compartment NA NA Rat Human +DTXSID2033281 Css NA 0.03856 mg/L 3compartmentss NA 50% Rat Human +DTXSID2033281 Css NA 0.2273 mg/L 3compartmentss NA 95% Rat Human +DTXSID2033281 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID2033281 Css NA 0.1369 mg/L PBTK NA 95% Rat Human DTXSID2033314 Clint NA 87.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2033314 Fup NA 0.1406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2033314 Vd NA 0.4699 L/kg 1compartment NA NA Human Human DTXSID2033314 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2033314 TK.Half.Life NA 0.5484 hours 1compartment NA NA Human Human -DTXSID2033314 Css NA 0.04966 mg/L 3compartmentss NA 50% Human Human -DTXSID2033314 Css NA 0.4279 mg/L 3compartmentss NA 95% Human Human -DTXSID2033314 Css NA 0.03176 mg/L PBTK NA 50% Human Human -DTXSID2033314 Css NA 0.2592 mg/L PBTK NA 95% Human Human +DTXSID2033314 Css NA 0.01814 mg/L 3compartmentss NA 50% Human Human +DTXSID2033314 Css NA 0.2386 mg/L 3compartmentss NA 95% Human Human +DTXSID2033314 Css NA 0.01162 mg/L PBTK NA 50% Human Human +DTXSID2033314 Css NA 0.1458 mg/L PBTK NA 95% Human Human DTXSID2033314 Clint NA 87.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2033314 Fup NA 0.1406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2033314 Vd NA 0.4592 L/kg 1compartment NA NA Rat Human DTXSID2033314 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2033314 TK.Half.Life NA 0.2691 hours 1compartment NA NA Rat Human -DTXSID2033314 Css NA 0.02818 mg/L 3compartmentss NA 50% Rat Human -DTXSID2033314 Css NA 0.1921 mg/L 3compartmentss NA 95% Rat Human -DTXSID2033314 Css NA 0.01703 mg/L PBTK NA 50% Rat Human -DTXSID2033314 Css NA 0.1132 mg/L PBTK NA 95% Rat Human -DTXSID2033445 Clint NA 7.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2033445 Fup NA 0.7857 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2033445 Vd NA 1.219 L/kg 1compartment NA NA Human Human -DTXSID2033445 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2033445 TK.Half.Life NA 1.345 hours 1compartment NA NA Human Human -DTXSID2033445 Css NA 0.0775 mg/L 3compartmentss NA 50% Human Human -DTXSID2033445 Css NA 0.6469 mg/L 3compartmentss NA 95% Human Human -DTXSID2033445 Css NA 0.06776 mg/L PBTK NA 50% Human Human -DTXSID2033445 Css NA 0.4643 mg/L PBTK NA 95% Human Human -DTXSID2033445 Clint NA 7.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2033445 Fup NA 0.7857 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2033445 Vd NA 1.211 L/kg 1compartment NA NA Rat Human +DTXSID2033314 Css NA 0.000173 mg/L 3compartmentss NA 50% Rat Human +DTXSID2033314 Css NA 0.002207 mg/L 3compartmentss NA 95% Rat Human +DTXSID2033314 Css NA 0.0001049 mg/L PBTK NA 50% Rat Human +DTXSID2033314 Css NA 0.001268 mg/L PBTK NA 95% Rat Human +DTXSID2033445 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2033445 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2033445 Vd NA 0.6627 L/kg 1compartment NA NA Human Human +DTXSID2033445 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2033445 TK.Half.Life NA 11.94 hours 1compartment NA NA Human Human +DTXSID2033445 Css NA 1.962 mg/L 3compartmentss NA 50% Human Human +DTXSID2033445 Css NA 8.063 mg/L 3compartmentss NA 95% Human Human +DTXSID2033445 Css NA 1.442 mg/L PBTK NA 50% Human Human +DTXSID2033445 Css NA 5.13 mg/L PBTK NA 95% Human Human +DTXSID2033445 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2033445 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2033445 Vd NA 0.6577 L/kg 1compartment NA NA Rat Human DTXSID2033445 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2033445 TK.Half.Life NA 0.7077 hours 1compartment NA NA Rat Human -DTXSID2033445 Css NA 0.03642 mg/L 3compartmentss NA 50% Rat Human -DTXSID2033445 Css NA 0.2886 mg/L 3compartmentss NA 95% Rat Human -DTXSID2033445 Css NA 0.03162 mg/L PBTK NA 50% Rat Human -DTXSID2033445 Css NA 0.186 mg/L PBTK NA 95% Rat Human -DTXSID2033493 Clint NA 1.768 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2033493 Fup NA 0.8208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2033493 Vd NA 1.095 L/kg 1compartment NA NA Human Human +DTXSID2033445 TK.Half.Life NA 4.037 hours 1compartment NA NA Rat Human +DTXSID2033445 Css NA 0.1261 mg/L 3compartmentss NA 50% Rat Human +DTXSID2033445 Css NA 0.444 mg/L 3compartmentss NA 95% Rat Human +DTXSID2033445 Css NA 0.09092 mg/L PBTK NA 50% Rat Human +DTXSID2033445 Css NA 0.2725 mg/L PBTK NA 95% Rat Human +DTXSID2033493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2033493 Fup 0.753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2033493 Vd NA 1.055 L/kg 1compartment NA NA Human Human DTXSID2033493 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2033493 TK.Half.Life NA 2.603 hours 1compartment NA NA Human Human -DTXSID2033493 Css NA 0.2443 mg/L 3compartmentss NA 50% Human Human -DTXSID2033493 Css NA 1.692 mg/L 3compartmentss NA 95% Human Human -DTXSID2033493 Css NA 0.213 mg/L PBTK NA 50% Human Human -DTXSID2033493 Css NA 1.172 mg/L PBTK NA 95% Human Human -DTXSID2033493 Clint NA 1.768 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2033493 Fup NA 0.8208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2033493 Vd NA 1.047 L/kg 1compartment NA NA Rat Human +DTXSID2033493 TK.Half.Life NA 0.826 hours 1compartment NA NA Human Human +DTXSID2033493 Css NA 0.02637 mg/L 3compartmentss NA 50% Human Human +DTXSID2033493 Css NA 0.2892 mg/L 3compartmentss NA 95% Human Human +DTXSID2033493 Css NA 0.02248 mg/L PBTK NA 50% Human Human +DTXSID2033493 Css NA 0.2138 mg/L PBTK NA 95% Human Human +DTXSID2033493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2033493 Fup 0.753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2033493 Vd NA 1.007 L/kg 1compartment NA NA Rat Human DTXSID2033493 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2033493 TK.Half.Life NA 1.254 hours 1compartment NA NA Rat Human -DTXSID2033493 Css NA 0.1007 mg/L 3compartmentss NA 50% Rat Human -DTXSID2033493 Css NA 0.6846 mg/L 3compartmentss NA 95% Rat Human -DTXSID2033493 Css NA 0.0868 mg/L PBTK NA 50% Rat Human -DTXSID2033493 Css NA 0.424 mg/L PBTK NA 95% Rat Human -DTXSID2033736 Clint NA 1051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2033736 Fup NA 0.0195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2033736 Vd NA 1.321 L/kg 1compartment NA NA Human Human +DTXSID2033493 TK.Half.Life NA 0.383 hours 1compartment NA NA Rat Human +DTXSID2033493 Css NA 0.003128 mg/L 3compartmentss NA 50% Rat Human +DTXSID2033493 Css NA 0.02992 mg/L 3compartmentss NA 95% Rat Human +DTXSID2033493 Css NA 0.00275 mg/L PBTK NA 50% Rat Human +DTXSID2033493 Css NA 0.0208 mg/L PBTK NA 95% Rat Human +DTXSID2033736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2033736 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2033736 Vd NA 0.5434 L/kg 1compartment NA NA Human Human DTXSID2033736 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2033736 TK.Half.Life NA 1.438 hours 1compartment NA NA Human Human -DTXSID2033736 Css NA 0.03141 mg/L 3compartmentss NA 50% Human Human -DTXSID2033736 Css NA 0.2926 mg/L 3compartmentss NA 95% Human Human -DTXSID2033736 Css NA 0.01958 mg/L PBTK NA 50% Human Human -DTXSID2033736 Css NA 0.1733 mg/L PBTK NA 95% Human Human -DTXSID2033736 Clint NA 1051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2033736 Fup NA 0.0195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2033736 Vd NA 0.9824 L/kg 1compartment NA NA Rat Human +DTXSID2033736 TK.Half.Life NA 1.268 hours 1compartment NA NA Human Human +DTXSID2033736 Css NA 0.2058 mg/L 3compartmentss NA 50% Human Human +DTXSID2033736 Css NA 1.743 mg/L 3compartmentss NA 95% Human Human +DTXSID2033736 Css NA 0.13 mg/L PBTK NA 50% Human Human +DTXSID2033736 Css NA 1.04 mg/L PBTK NA 95% Human Human +DTXSID2033736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2033736 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2033736 Vd NA 0.4621 L/kg 1compartment NA NA Rat Human DTXSID2033736 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2033736 TK.Half.Life NA 0.4912 hours 1compartment NA NA Rat Human -DTXSID2033736 Css NA 0.01784 mg/L 3compartmentss NA 50% Rat Human -DTXSID2033736 Css NA 0.1462 mg/L 3compartmentss NA 95% Rat Human -DTXSID2033736 Css NA 0.0104 mg/L PBTK NA 50% Rat Human -DTXSID2033736 Css NA 0.08162 mg/L PBTK NA 95% Rat Human -DTXSID2034091 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034091 Fup NA 0.7185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034091 Vd NA 1.293 L/kg 1compartment NA NA Human Human -DTXSID2034091 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2034091 TK.Half.Life NA 12.73 hours 1compartment NA NA Human Human -DTXSID2034091 Css NA 1.028 mg/L 3compartmentss NA 50% Human Human -DTXSID2034091 Css NA 6.738 mg/L 3compartmentss NA 95% Human Human -DTXSID2034091 Css NA 0.9128 mg/L PBTK NA 50% Human Human -DTXSID2034091 Css NA 4.429 mg/L PBTK NA 95% Human Human -DTXSID2034091 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034091 Fup NA 0.7185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034091 Vd NA 1.174 L/kg 1compartment NA NA Rat Human +DTXSID2033736 TK.Half.Life NA 0.6222 hours 1compartment NA NA Rat Human +DTXSID2033736 Css NA 0.009994 mg/L 3compartmentss NA 50% Rat Human +DTXSID2033736 Css NA 0.09704 mg/L 3compartmentss NA 95% Rat Human +DTXSID2033736 Css NA 0.006124 mg/L PBTK NA 50% Rat Human +DTXSID2033736 Css NA 0.05695 mg/L PBTK NA 95% Rat Human +DTXSID2034091 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034091 Fup 0.51 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034091 Vd NA 1.041 L/kg 1compartment NA NA Human Human +DTXSID2034091 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2034091 TK.Half.Life NA 1.01 hours 1compartment NA NA Human Human +DTXSID2034091 Css NA 0.037 mg/L 3compartmentss NA 50% Human Human +DTXSID2034091 Css NA 0.3557 mg/L 3compartmentss NA 95% Human Human +DTXSID2034091 Css NA 0.02994 mg/L PBTK NA 50% Human Human +DTXSID2034091 Css NA 0.2506 mg/L PBTK NA 95% Human Human +DTXSID2034091 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034091 Fup 0.51 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034091 Vd NA 0.9447 L/kg 1compartment NA NA Rat Human DTXSID2034091 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034091 TK.Half.Life NA 3.683 hours 1compartment NA NA Rat Human -DTXSID2034091 Css NA 0.2667 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034091 Css NA 1.725 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034091 Css NA 0.2313 mg/L PBTK NA 50% Rat Human -DTXSID2034091 Css NA 1.055 mg/L PBTK NA 95% Rat Human -DTXSID2034095 Clint NA 426.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034095 Fup NA 0.0713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034095 Vd NA 2.469 L/kg 1compartment NA NA Human Human +DTXSID2034091 TK.Half.Life NA 0.4572 hours 1compartment NA NA Rat Human +DTXSID2034091 Css NA 0.004625 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034091 Css NA 0.03294 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034091 Css NA 0.003784 mg/L PBTK NA 50% Rat Human +DTXSID2034091 Css NA 0.02263 mg/L PBTK NA 95% Rat Human +DTXSID2034095 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034095 Fup 0.0323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034095 Vd NA 2.162 L/kg 1compartment NA NA Human Human DTXSID2034095 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2034095 TK.Half.Life NA 1.898 hours 1compartment NA NA Human Human -DTXSID2034095 Css NA 0.01148 mg/L 3compartmentss NA 50% Human Human -DTXSID2034095 Css NA 0.09649 mg/L 3compartmentss NA 95% Human Human -DTXSID2034095 Css NA 0.009004 mg/L PBTK NA 50% Human Human -DTXSID2034095 Css NA 0.06896 mg/L PBTK NA 95% Human Human -DTXSID2034095 Clint NA 426.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034095 Fup NA 0.0713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034095 Vd NA 2.263 L/kg 1compartment NA NA Rat Human +DTXSID2034095 TK.Half.Life NA 7.63 hours 1compartment NA NA Human Human +DTXSID2034095 Css NA 0.4234 mg/L 3compartmentss NA 50% Human Human +DTXSID2034095 Css NA 3.972 mg/L 3compartmentss NA 95% Human Human +DTXSID2034095 Css NA 0.3016 mg/L PBTK NA 50% Human Human +DTXSID2034095 Css NA 2.575 mg/L PBTK NA 95% Human Human +DTXSID2034095 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034095 Fup 0.0323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034095 Vd NA 1.863 L/kg 1compartment NA NA Rat Human DTXSID2034095 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034095 TK.Half.Life NA 0.7898 hours 1compartment NA NA Rat Human -DTXSID2034095 Css NA 0.006415 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034095 Css NA 0.04235 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034095 Css NA 0.004906 mg/L PBTK NA 50% Rat Human -DTXSID2034095 Css NA 0.02965 mg/L PBTK NA 95% Rat Human +DTXSID2034095 TK.Half.Life NA 3.43 hours 1compartment NA NA Rat Human +DTXSID2034095 Css NA 0.05497 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034095 Css NA 0.426 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034095 Css NA 0.03832 mg/L PBTK NA 50% Rat Human +DTXSID2034095 Css NA 0.2697 mg/L PBTK NA 95% Rat Human +DTXSID20342515 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20342515 Fup 0.00929 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20342515 Vd NA 2.752 L/kg 1compartment NA NA Human Human +DTXSID20342515 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID20342515 TK.Half.Life NA 56.31 hours 1compartment NA NA Human Human +DTXSID20342515 Css NA 2.755 mg/L 3compartmentss NA 50% Human Human +DTXSID20342515 Css NA 20.04 mg/L 3compartmentss NA 95% Human Human +DTXSID20342515 Css NA 1.852 mg/L PBTK NA 50% Human Human +DTXSID20342515 Css NA 12.94 mg/L PBTK NA 95% Human Human +DTXSID20342515 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20342515 Fup 0.00929 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20342515 Vd NA 2.056 L/kg 1compartment NA NA Rat Human +DTXSID20342515 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID20342515 TK.Half.Life NA 11.38 hours 1compartment NA NA Rat Human +DTXSID20342515 Css NA 0.3598 mg/L 3compartmentss NA 50% Rat Human +DTXSID20342515 Css NA 2.175 mg/L 3compartmentss NA 95% Rat Human +DTXSID20342515 Css NA 0.237 mg/L PBTK NA 50% Rat Human +DTXSID20342515 Css NA 1.387 mg/L PBTK NA 95% Rat Human DTXSID2034255 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2034255 Fup NA 0.7598 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2034255 Vd NA 0.6547 L/kg 1compartment NA NA Human Human DTXSID2034255 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2034255 TK.Half.Life NA 5.576 hours 1compartment NA NA Human Human -DTXSID2034255 Css NA 1.047 mg/L 3compartmentss NA 50% Human Human -DTXSID2034255 Css NA 6.413 mg/L 3compartmentss NA 95% Human Human -DTXSID2034255 Css NA 0.8408 mg/L PBTK NA 50% Human Human -DTXSID2034255 Css NA 4.129 mg/L PBTK NA 95% Human Human +DTXSID2034255 Css NA 0.8843 mg/L 3compartmentss NA 50% Human Human +DTXSID2034255 Css NA 5.402 mg/L 3compartmentss NA 95% Human Human +DTXSID2034255 Css NA 0.7153 mg/L PBTK NA 50% Human Human +DTXSID2034255 Css NA 3.444 mg/L PBTK NA 95% Human Human DTXSID2034255 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2034255 Fup NA 0.7598 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2034255 Vd NA 0.6847 L/kg 1compartment NA NA Rat Human DTXSID2034255 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2034255 TK.Half.Life NA 1.987 hours 1compartment NA NA Rat Human -DTXSID2034255 Css NA 0.2711 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034255 Css NA 1.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034255 Css NA 0.2096 mg/L PBTK NA 50% Rat Human -DTXSID2034255 Css NA 0.9848 mg/L PBTK NA 95% Rat Human -DTXSID2034259 Clint NA 0.8113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034259 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034259 Vd NA 0.923 L/kg 1compartment NA NA Human Human +DTXSID2034255 Css NA 0.01714 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034255 Css NA 0.135 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034255 Css NA 0.01316 mg/L PBTK NA 50% Rat Human +DTXSID2034255 Css NA 0.08548 mg/L PBTK NA 95% Rat Human +DTXSID2034259 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034259 Fup 0.498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034259 Vd NA 0.5801 L/kg 1compartment NA NA Human Human DTXSID2034259 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2034259 TK.Half.Life NA 2.731 hours 1compartment NA NA Human Human -DTXSID2034259 Css NA 0.3415 mg/L 3compartmentss NA 50% Human Human -DTXSID2034259 Css NA 2.429 mg/L 3compartmentss NA 95% Human Human -DTXSID2034259 Css NA 0.2968 mg/L PBTK NA 50% Human Human -DTXSID2034259 Css NA 1.635 mg/L PBTK NA 95% Human Human -DTXSID2034259 Clint NA 0.8113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034259 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034259 Vd NA 0.9394 L/kg 1compartment NA NA Rat Human +DTXSID2034259 TK.Half.Life NA 7.548 hours 1compartment NA NA Human Human +DTXSID2034259 Css NA 1.235 mg/L 3compartmentss NA 50% Human Human +DTXSID2034259 Css NA 6.319 mg/L 3compartmentss NA 95% Human Human +DTXSID2034259 Css NA 0.9327 mg/L PBTK NA 50% Human Human +DTXSID2034259 Css NA 4.043 mg/L PBTK NA 95% Human Human +DTXSID2034259 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034259 Fup 0.498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034259 Vd NA 0.5937 L/kg 1compartment NA NA Rat Human DTXSID2034259 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034259 TK.Half.Life NA 1.291 hours 1compartment NA NA Rat Human -DTXSID2034259 Css NA 0.1226 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034259 Css NA 0.8236 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034259 Css NA 0.1058 mg/L PBTK NA 50% Rat Human -DTXSID2034259 Css NA 0.4993 mg/L PBTK NA 95% Rat Human -DTXSID2034338 Clint NA 10.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034338 Fup NA 0.1271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034338 Vd NA 0.8026 L/kg 1compartment NA NA Human Human +DTXSID2034259 TK.Half.Life NA 2.63 hours 1compartment NA NA Rat Human +DTXSID2034259 Css NA 0.02318 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034259 Css NA 0.1642 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034259 Css NA 0.01706 mg/L PBTK NA 50% Rat Human +DTXSID2034259 Css NA 0.105 mg/L PBTK NA 95% Rat Human +DTXSID2034338 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034338 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034338 Vd NA 1.299 L/kg 1compartment NA NA Human Human DTXSID2034338 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2034338 TK.Half.Life NA 2.893 hours 1compartment NA NA Human Human -DTXSID2034338 Css NA 0.4486 mg/L 3compartmentss NA 50% Human Human -DTXSID2034338 Css NA 3.183 mg/L 3compartmentss NA 95% Human Human -DTXSID2034338 Css NA 0.2917 mg/L PBTK NA 50% Human Human -DTXSID2034338 Css NA 1.952 mg/L PBTK NA 95% Human Human -DTXSID2034338 Clint NA 10.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034338 Fup NA 0.1271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034338 Vd NA 0.6593 L/kg 1compartment NA NA Rat Human +DTXSID2034338 TK.Half.Life NA 3.433 hours 1compartment NA NA Human Human +DTXSID2034338 Css NA 0.2261 mg/L 3compartmentss NA 50% Human Human +DTXSID2034338 Css NA 1.397 mg/L 3compartmentss NA 95% Human Human +DTXSID2034338 Css NA 0.1715 mg/L PBTK NA 50% Human Human +DTXSID2034338 Css NA 0.9427 mg/L PBTK NA 95% Human Human +DTXSID2034338 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034338 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034338 Vd NA 1.075 L/kg 1compartment NA NA Rat Human DTXSID2034338 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034338 TK.Half.Life NA 1.377 hours 1compartment NA NA Rat Human -DTXSID2034338 Css NA 0.242 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034338 Css NA 1.299 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034338 Css NA 0.1495 mg/L PBTK NA 50% Rat Human -DTXSID2034338 Css NA 0.742 mg/L PBTK NA 95% Rat Human -DTXSID2034382 Clint NA 60.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034382 Fup NA 0.0098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034382 Vd NA 3.857 L/kg 1compartment NA NA Human Human -DTXSID2034382 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID2034382 TK.Half.Life NA 43.7 hours 1compartment NA NA Human Human -DTXSID2034382 Css NA 1.196 mg/L 3compartmentss NA 50% Human Human -DTXSID2034382 Css NA 6.853 mg/L 3compartmentss NA 95% Human Human -DTXSID2034382 Css NA 0.8854 mg/L PBTK NA 50% Human Human -DTXSID2034382 Css NA 4.985 mg/L PBTK NA 95% Human Human -DTXSID2034382 Clint NA 60.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034382 Fup NA 0.0098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034382 Vd NA 2.913 L/kg 1compartment NA NA Rat Human -DTXSID2034382 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2034382 TK.Half.Life NA 6.365 hours 1compartment NA NA Rat Human -DTXSID2034382 Css NA 0.6786 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034382 Css NA 2.916 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034382 Css NA 0.4796 mg/L PBTK NA 50% Rat Human -DTXSID2034382 Css NA 2.038 mg/L PBTK NA 95% Rat Human +DTXSID2034338 TK.Half.Life NA 1.484 hours 1compartment NA NA Rat Human +DTXSID2034338 Css NA 0.02653 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034338 Css NA 0.1224 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034338 Css NA 0.0201 mg/L PBTK NA 50% Rat Human +DTXSID2034338 Css NA 0.08145 mg/L PBTK NA 95% Rat Human +DTXSID2034382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034382 Fup 0.00832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034382 Vd NA 3.851 L/kg 1compartment NA NA Human Human +DTXSID2034382 Days.Css NA 20 Days PBTK NA NA Human Human +DTXSID2034382 TK.Half.Life NA 116.8 hours 1compartment NA NA Human Human +DTXSID2034382 Css NA 3.276 mg/L 3compartmentss NA 50% Human Human +DTXSID2034382 Css NA 19.94 mg/L 3compartmentss NA 95% Human Human +DTXSID2034382 Css NA 2.412 mg/L PBTK NA 50% Human Human +DTXSID2034382 Css NA 14.47 mg/L PBTK NA 95% Human Human +DTXSID2034382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034382 Fup 0.00832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034382 Vd NA 2.909 L/kg 1compartment NA NA Rat Human +DTXSID2034382 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID2034382 TK.Half.Life NA 16.13 hours 1compartment NA NA Rat Human +DTXSID2034382 Css NA 0.4276 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034382 Css NA 2.157 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034382 Css NA 0.3144 mg/L PBTK NA 50% Rat Human +DTXSID2034382 Css NA 1.605 mg/L PBTK NA 95% Rat Human DTXSID2034465 Clint 10.73 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2034465 Fup 0.5059 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2034465 Vd NA 0.5062 L/kg 1compartment NA NA Human Human DTXSID2034465 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2034465 TK.Half.Life NA 0.6769 hours 1compartment NA NA Human Human -DTXSID2034465 Css NA 0.0855 mg/L 3compartmentss NA 50% Human Human -DTXSID2034465 Css NA 0.6694 mg/L 3compartmentss NA 95% Human Human -DTXSID2034465 Css NA 0.06196 mg/L PBTK NA 50% Human Human -DTXSID2034465 Css NA 0.4332 mg/L PBTK NA 95% Human Human +DTXSID2034465 Css NA 0.08133 mg/L 3compartmentss NA 50% Human Human +DTXSID2034465 Css NA 0.6682 mg/L 3compartmentss NA 95% Human Human +DTXSID2034465 Css NA 0.05911 mg/L PBTK NA 50% Human Human +DTXSID2034465 Css NA 0.4271 mg/L PBTK NA 95% Human Human DTXSID2034465 Clint 10.73 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2034465 Fup 0.5059 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2034465 Vd NA 0.5035 L/kg 1compartment NA NA Rat Human DTXSID2034465 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2034465 TK.Half.Life NA 0.356 hours 1compartment NA NA Rat Human -DTXSID2034465 Css NA 0.0447 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034465 Css NA 0.2833 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034465 Css NA 0.03104 mg/L PBTK NA 50% Rat Human -DTXSID2034465 Css NA 0.1743 mg/L PBTK NA 95% Rat Human -DTXSID2034540 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034540 Fup NA 0.3429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034540 Vd NA 0.597 L/kg 1compartment NA NA Human Human -DTXSID2034540 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2034540 TK.Half.Life NA 11.26 hours 1compartment NA NA Human Human -DTXSID2034540 Css NA 2.077 mg/L 3compartmentss NA 50% Human Human -DTXSID2034540 Css NA 8.522 mg/L 3compartmentss NA 95% Human Human -DTXSID2034540 Css NA 1.563 mg/L PBTK NA 50% Human Human -DTXSID2034540 Css NA 5.491 mg/L PBTK NA 95% Human Human -DTXSID2034540 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034540 Fup NA 0.3429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034540 Vd NA 0.6018 L/kg 1compartment NA NA Rat Human +DTXSID2034465 Css NA 0.009732 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034465 Css NA 0.05938 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034465 Css NA 0.007032 mg/L PBTK NA 50% Rat Human +DTXSID2034465 Css NA 0.03804 mg/L PBTK NA 95% Rat Human +DTXSID2034540 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034540 Fup 0.621 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034540 Vd NA 0.776 L/kg 1compartment NA NA Human Human +DTXSID2034540 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2034540 TK.Half.Life NA 8.085 hours 1compartment NA NA Human Human +DTXSID2034540 Css NA 1.098 mg/L 3compartmentss NA 50% Human Human +DTXSID2034540 Css NA 7.746 mg/L 3compartmentss NA 95% Human Human +DTXSID2034540 Css NA 0.9284 mg/L PBTK NA 50% Human Human +DTXSID2034540 Css NA 4.901 mg/L PBTK NA 95% Human Human +DTXSID2034540 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034540 Fup 0.621 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034540 Vd NA 0.7899 L/kg 1compartment NA NA Rat Human DTXSID2034540 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034540 TK.Half.Life NA 3.87 hours 1compartment NA NA Rat Human -DTXSID2034540 Css NA 0.5604 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034540 Css NA 2.039 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034540 Css NA 0.4048 mg/L PBTK NA 50% Rat Human -DTXSID2034540 Css NA 1.224 mg/L PBTK NA 95% Rat Human -DTXSID2034542 Clint NA 43.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034542 Fup NA 0.1198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034542 Vd NA 0.9644 L/kg 1compartment NA NA Human Human +DTXSID2034540 TK.Half.Life NA 2.805 hours 1compartment NA NA Rat Human +DTXSID2034540 Css NA 0.06604 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034540 Css NA 0.4565 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034540 Css NA 0.05594 mg/L PBTK NA 50% Rat Human +DTXSID2034540 Css NA 0.2816 mg/L PBTK NA 95% Rat Human +DTXSID2034542 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034542 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034542 Vd NA 1.375 L/kg 1compartment NA NA Human Human DTXSID2034542 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2034542 TK.Half.Life NA 1.527 hours 1compartment NA NA Human Human -DTXSID2034542 Css NA 0.1205 mg/L 3compartmentss NA 50% Human Human -DTXSID2034542 Css NA 0.9953 mg/L 3compartmentss NA 95% Human Human -DTXSID2034542 Css NA 0.07908 mg/L PBTK NA 50% Human Human -DTXSID2034542 Css NA 0.619 mg/L PBTK NA 95% Human Human -DTXSID2034542 Clint NA 43.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034542 Fup NA 0.1198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034542 Vd NA 0.7706 L/kg 1compartment NA NA Rat Human +DTXSID2034542 TK.Half.Life NA 2.147 hours 1compartment NA NA Human Human +DTXSID2034542 Css NA 0.09757 mg/L 3compartmentss NA 50% Human Human +DTXSID2034542 Css NA 0.7033 mg/L 3compartmentss NA 95% Human Human +DTXSID2034542 Css NA 0.0713 mg/L PBTK NA 50% Human Human +DTXSID2034542 Css NA 0.474 mg/L PBTK NA 95% Human Human +DTXSID2034542 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034542 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034542 Vd NA 1.106 L/kg 1compartment NA NA Rat Human DTXSID2034542 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034542 TK.Half.Life NA 0.6412 hours 1compartment NA NA Rat Human -DTXSID2034542 Css NA 0.06798 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034542 Css NA 0.4462 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034542 Css NA 0.04216 mg/L PBTK NA 50% Rat Human -DTXSID2034542 Css NA 0.2609 mg/L PBTK NA 95% Rat Human +DTXSID2034542 TK.Half.Life NA 0.87 hours 1compartment NA NA Rat Human +DTXSID2034542 Css NA 0.0122 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034542 Css NA 0.0691 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034542 Css NA 0.00885 mg/L PBTK NA 50% Rat Human +DTXSID2034542 Css NA 0.04551 mg/L PBTK NA 95% Rat Human DTXSID2034590 Clint 17.74 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2034590 Fup 0.02436 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID2034590 Vd NA 0.7737 L/kg 1compartment NA NA Human Human +DTXSID2034590 Vd NA 1.031 L/kg 1compartment NA NA Human Human DTXSID2034590 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2034590 TK.Half.Life NA 6.944 hours 1compartment NA NA Human Human -DTXSID2034590 Css NA 1.498 mg/L 3compartmentss NA 50% Human Human -DTXSID2034590 Css NA 13.52 mg/L 3compartmentss NA 95% Human Human -DTXSID2034590 Css NA 0.912 mg/L PBTK NA 50% Human Human -DTXSID2034590 Css NA 8.041 mg/L PBTK NA 95% Human Human +DTXSID2034590 TK.Half.Life NA 9.322 hours 1compartment NA NA Human Human +DTXSID2034590 Css NA 1.441 mg/L 3compartmentss NA 50% Human Human +DTXSID2034590 Css NA 13.24 mg/L 3compartmentss NA 95% Human Human +DTXSID2034590 Css NA 0.8841 mg/L PBTK NA 50% Human Human +DTXSID2034590 Css NA 7.964 mg/L PBTK NA 95% Human Human DTXSID2034590 Clint 17.74 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2034590 Fup 0.02436 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID2034590 Vd NA 0.5864 L/kg 1compartment NA NA Rat Human +DTXSID2034590 Vd NA 0.7715 L/kg 1compartment NA NA Rat Human DTXSID2034590 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034590 TK.Half.Life NA 3.225 hours 1compartment NA NA Rat Human -DTXSID2034590 Css NA 0.8401 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034590 Css NA 6.441 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034590 Css NA 0.4757 mg/L PBTK NA 50% Rat Human -DTXSID2034590 Css NA 3.532 mg/L PBTK NA 95% Rat Human +DTXSID2034590 TK.Half.Life NA 4.073 hours 1compartment NA NA Rat Human +DTXSID2034590 Css NA 0.189 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034590 Css NA 1.452 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034590 Css NA 0.1124 mg/L PBTK NA 50% Rat Human +DTXSID2034590 Css NA 0.8298 mg/L PBTK NA 95% Rat Human DTXSID2034598 Clint 519 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2034598 Fup 0.00635 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2034598 Vd NA 2.345 L/kg 1compartment NA NA Human Human DTXSID2034598 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2034598 TK.Half.Life NA 4.007 hours 1compartment NA NA Human Human -DTXSID2034598 Css NA 0.1124 mg/L 3compartmentss NA 50% Human Human -DTXSID2034598 Css NA 0.7601 mg/L 3compartmentss NA 95% Human Human -DTXSID2034598 Css NA 0.07429 mg/L PBTK NA 50% Human Human -DTXSID2034598 Css NA 0.4832 mg/L PBTK NA 95% Human Human +DTXSID2034598 Css NA 0.1046 mg/L 3compartmentss NA 50% Human Human +DTXSID2034598 Css NA 0.8156 mg/L 3compartmentss NA 95% Human Human +DTXSID2034598 Css NA 0.06909 mg/L PBTK NA 50% Human Human +DTXSID2034598 Css NA 0.5102 mg/L PBTK NA 95% Human Human DTXSID2034598 Clint 519 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2034598 Fup 0.00635 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2034598 Vd NA 1.742 L/kg 1compartment NA NA Rat Human DTXSID2034598 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2034598 TK.Half.Life NA 1.191 hours 1compartment NA NA Rat Human -DTXSID2034598 Css NA 0.06273 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034598 Css NA 0.362 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034598 Css NA 0.03924 mg/L PBTK NA 50% Rat Human -DTXSID2034598 Css NA 0.223 mg/L PBTK NA 95% Rat Human +DTXSID2034598 Css NA 0.01394 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034598 Css NA 0.08787 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034598 Css NA 0.009046 mg/L PBTK NA 50% Rat Human +DTXSID2034598 Css NA 0.05546 mg/L PBTK NA 95% Rat Human DTXSID2034625 Clint 16.35 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2034625 Fup 0.0362 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID2034625 Vd NA 2.578 L/kg 1compartment NA NA Human Human -DTXSID2034625 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2034625 TK.Half.Life NA 30.9 hours 1compartment NA NA Human Human -DTXSID2034625 Css NA 1.64 mg/L 3compartmentss NA 50% Human Human -DTXSID2034625 Css NA 10.98 mg/L 3compartmentss NA 95% Human Human -DTXSID2034625 Css NA 1.101 mg/L PBTK NA 50% Human Human -DTXSID2034625 Css NA 7.118 mg/L PBTK NA 95% Human Human +DTXSID2034625 Vd NA 2.211 L/kg 1compartment NA NA Human Human +DTXSID2034625 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2034625 TK.Half.Life NA 21.1 hours 1compartment NA NA Human Human +DTXSID2034625 Css NA 1.355 mg/L 3compartmentss NA 50% Human Human +DTXSID2034625 Css NA 9.444 mg/L 3compartmentss NA 95% Human Human +DTXSID2034625 Css NA 0.887 mg/L PBTK NA 50% Human Human +DTXSID2034625 Css NA 5.971 mg/L PBTK NA 95% Human Human DTXSID2034625 Clint 16.35 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2034625 Fup 0.0362 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID2034625 Vd NA 1.929 L/kg 1compartment NA NA Rat Human +DTXSID2034625 Vd NA 1.652 L/kg 1compartment NA NA Rat Human DTXSID2034625 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2034625 TK.Half.Life NA 7.266 hours 1compartment NA NA Rat Human -DTXSID2034625 Css NA 0.9143 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034625 Css NA 4.635 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034625 Css NA 0.5832 mg/L PBTK NA 50% Rat Human -DTXSID2034625 Css NA 2.874 mg/L PBTK NA 95% Rat Human +DTXSID2034625 TK.Half.Life NA 6.167 hours 1compartment NA NA Rat Human +DTXSID2034625 Css NA 0.1744 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034625 Css NA 0.9768 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034625 Css NA 0.1119 mg/L PBTK NA 50% Rat Human +DTXSID2034625 Css NA 0.608 mg/L PBTK NA 95% Rat Human DTXSID2034627 Clint 1.791 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2034627 Fup 0.09194 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID2034627 Vd NA 0.3269 L/kg 1compartment NA NA Human Human +DTXSID2034627 Vd NA 0.3657 L/kg 1compartment NA NA Human Human DTXSID2034627 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2034627 TK.Half.Life NA 5.945 hours 1compartment NA NA Human Human -DTXSID2034627 Css NA 2.869 mg/L 3compartmentss NA 50% Human Human -DTXSID2034627 Css NA 16.35 mg/L 3compartmentss NA 95% Human Human -DTXSID2034627 Css NA 1.803 mg/L PBTK NA 50% Human Human -DTXSID2034627 Css NA 9.604 mg/L PBTK NA 95% Human Human +DTXSID2034627 TK.Half.Life NA 6.671 hours 1compartment NA NA Human Human +DTXSID2034627 Css NA 2.778 mg/L 3compartmentss NA 50% Human Human +DTXSID2034627 Css NA 15.83 mg/L 3compartmentss NA 95% Human Human +DTXSID2034627 Css NA 1.755 mg/L PBTK NA 50% Human Human +DTXSID2034627 Css NA 9.356 mg/L PBTK NA 95% Human Human DTXSID2034627 Clint 1.791 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2034627 Fup 0.09194 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID2034627 Vd NA 0.3246 L/kg 1compartment NA NA Rat Human +DTXSID2034627 Vd NA 0.3611 L/kg 1compartment NA NA Rat Human DTXSID2034627 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034627 TK.Half.Life NA 3.227 hours 1compartment NA NA Rat Human -DTXSID2034627 Css NA 1.31 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034627 Css NA 5.809 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034627 Css NA 0.768 mg/L PBTK NA 50% Rat Human -DTXSID2034627 Css NA 3.203 mg/L PBTK NA 95% Rat Human +DTXSID2034627 TK.Half.Life NA 3.599 hours 1compartment NA NA Rat Human +DTXSID2034627 Css NA 0.2934 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034627 Css NA 1.302 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034627 Css NA 0.1807 mg/L PBTK NA 50% Rat Human +DTXSID2034627 Css NA 0.7518 mg/L PBTK NA 95% Rat Human DTXSID2034673 Clint 5.691 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2034673 Fup 0.006681 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID2034673 Vd NA 0.1751 L/kg 1compartment NA NA Human Human +DTXSID2034673 Vd NA 0.1744 L/kg 1compartment NA NA Human Human DTXSID2034673 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2034673 TK.Half.Life NA 16.38 hours 1compartment NA NA Human Human -DTXSID2034673 Css NA 17.86 mg/L 3compartmentss NA 50% Human Human -DTXSID2034673 Css NA 146 mg/L 3compartmentss NA 95% Human Human -DTXSID2034673 Css NA 10.43 mg/L PBTK NA 50% Human Human -DTXSID2034673 Css NA 83.46 mg/L PBTK NA 95% Human Human +DTXSID2034673 TK.Half.Life NA 16.3 hours 1compartment NA NA Human Human +DTXSID2034673 Css NA 16.66 mg/L 3compartmentss NA 50% Human Human +DTXSID2034673 Css NA 140.6 mg/L 3compartmentss NA 95% Human Human +DTXSID2034673 Css NA 9.668 mg/L PBTK NA 50% Human Human +DTXSID2034673 Css NA 82.37 mg/L PBTK NA 95% Human Human DTXSID2034673 Clint 5.691 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2034673 Fup 0.006681 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID2034673 Vd NA 0.1727 L/kg 1compartment NA NA Rat Human +DTXSID2034673 Vd NA 0.172 L/kg 1compartment NA NA Rat Human DTXSID2034673 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2034673 TK.Half.Life NA 10.26 hours 1compartment NA NA Rat Human -DTXSID2034673 Css NA 9.324 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034673 Css NA 62.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034673 Css NA 5.068 mg/L PBTK NA 50% Rat Human -DTXSID2034673 Css NA 33.6 mg/L PBTK NA 95% Rat Human -DTXSID2034700 Clint NA 1.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034700 Fup NA 0.0506 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034700 Vd NA 0.3479 L/kg 1compartment NA NA Human Human -DTXSID2034700 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2034700 TK.Half.Life NA 11.81 hours 1compartment NA NA Human Human -DTXSID2034700 Css NA 5.624 mg/L 3compartmentss NA 50% Human Human -DTXSID2034700 Css NA 33.47 mg/L 3compartmentss NA 95% Human Human -DTXSID2034700 Css NA 3.516 mg/L PBTK NA 50% Human Human -DTXSID2034700 Css NA 19.58 mg/L PBTK NA 95% Human Human -DTXSID2034700 Clint NA 1.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034700 Fup NA 0.0506 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034700 Vd NA 0.3379 L/kg 1compartment NA NA Rat Human -DTXSID2034700 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034700 TK.Half.Life NA 6.256 hours 1compartment NA NA Rat Human -DTXSID2034700 Css NA 2.561 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034700 Css NA 12.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034700 Css NA 1.502 mg/L PBTK NA 50% Rat Human -DTXSID2034700 Css NA 6.719 mg/L PBTK NA 95% Rat Human -DTXSID2034833 Clint NA 1.061 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034833 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034833 Vd NA 0.2039 L/kg 1compartment NA NA Human Human -DTXSID2034833 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2034833 TK.Half.Life NA 18.15 hours 1compartment NA NA Human Human -DTXSID2034833 Css NA 15.62 mg/L 3compartmentss NA 50% Human Human -DTXSID2034833 Css NA 104.7 mg/L 3compartmentss NA 95% Human Human -DTXSID2034833 Css NA 9.182 mg/L PBTK NA 50% Human Human -DTXSID2034833 Css NA 60.6 mg/L PBTK NA 95% Human Human -DTXSID2034833 Clint NA 1.061 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034833 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034833 Vd NA 0.1979 L/kg 1compartment NA NA Rat Human +DTXSID2034673 TK.Half.Life NA 10.21 hours 1compartment NA NA Rat Human +DTXSID2034673 Css NA 1.524 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034673 Css NA 11.02 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034673 Css NA 0.8534 mg/L PBTK NA 50% Rat Human +DTXSID2034673 Css NA 6.151 mg/L PBTK NA 95% Rat Human +DTXSID2034700 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034700 Fup 0.0744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034700 Vd NA 0.3316 L/kg 1compartment NA NA Human Human +DTXSID2034700 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2034700 TK.Half.Life NA 28.85 hours 1compartment NA NA Human Human +DTXSID2034700 Css NA 13.34 mg/L 3compartmentss NA 50% Human Human +DTXSID2034700 Css NA 60.02 mg/L 3compartmentss NA 95% Human Human +DTXSID2034700 Css NA 8.341 mg/L PBTK NA 50% Human Human +DTXSID2034700 Css NA 35.4 mg/L PBTK NA 95% Human Human +DTXSID2034700 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034700 Fup 0.0744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034700 Vd NA 0.3257 L/kg 1compartment NA NA Rat Human +DTXSID2034700 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2034700 TK.Half.Life NA 9.653 hours 1compartment NA NA Rat Human +DTXSID2034700 Css NA 0.8738 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034700 Css NA 3.331 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034700 Css NA 0.5288 mg/L PBTK NA 50% Rat Human +DTXSID2034700 Css NA 1.904 mg/L PBTK NA 95% Rat Human +DTXSID2034833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034833 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034833 Vd NA 0.3418 L/kg 1compartment NA NA Human Human +DTXSID2034833 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2034833 TK.Half.Life NA 0.6782 hours 1compartment NA NA Human Human +DTXSID2034833 Css NA 0.1735 mg/L 3compartmentss NA 50% Human Human +DTXSID2034833 Css NA 1.351 mg/L 3compartmentss NA 95% Human Human +DTXSID2034833 Css NA 0.1108 mg/L PBTK NA 50% Human Human +DTXSID2034833 Css NA 0.8315 mg/L PBTK NA 95% Human Human +DTXSID2034833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034833 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034833 Vd NA 0.3418 L/kg 1compartment NA NA Rat Human DTXSID2034833 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034833 TK.Half.Life NA 8.919 hours 1compartment NA NA Rat Human -DTXSID2034833 Css NA 6.678 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034833 Css NA 37.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034833 Css NA 3.678 mg/L PBTK NA 50% Rat Human -DTXSID2034833 Css NA 20.19 mg/L PBTK NA 95% Rat Human +DTXSID2034833 TK.Half.Life NA 0.3872 hours 1compartment NA NA Rat Human +DTXSID2034833 Css NA 0.02251 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034833 Css NA 0.1443 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034833 Css NA 0.01407 mg/L PBTK NA 50% Rat Human +DTXSID2034833 Css NA 0.08498 mg/L PBTK NA 95% Rat Human DTXSID2034881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID2034881 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034881 Vd NA 2.932 L/kg 1compartment NA NA Human Human -DTXSID2034881 Days.Css NA 1904 Days PBTK NA NA Human Human -DTXSID2034881 TK.Half.Life NA 6977 hours 1compartment NA NA Human Human -DTXSID2034881 Css NA 294.4 mg/L 3compartmentss NA 50% Human Human -DTXSID2034881 Css NA 872.6 mg/L 3compartmentss NA 95% Human Human -DTXSID2034881 Css NA 202 mg/L PBTK NA 50% Human Human -DTXSID2034881 Css NA 556.2 mg/L PBTK NA 95% Human Human +DTXSID2034881 Fup 0.00853 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034881 Vd NA 2.579 L/kg 1compartment NA NA Human Human +DTXSID2034881 Days.Css NA 2039 Days PBTK NA NA Human Human +DTXSID2034881 TK.Half.Life NA 7458 hours 1compartment NA NA Human Human +DTXSID2034881 Css NA 380.3 mg/L 3compartmentss NA 50% Human Human +DTXSID2034881 Css NA 1348 mg/L 3compartmentss NA 95% Human Human +DTXSID2034881 Css NA 251.8 mg/L PBTK NA 50% Human Human +DTXSID2034881 Css NA 832.3 mg/L PBTK NA 95% Human Human DTXSID2034881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID2034881 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034881 Vd NA 2.195 L/kg 1compartment NA NA Rat Human -DTXSID2034881 Days.Css NA 483 Days PBTK NA NA Rat Human -DTXSID2034881 TK.Half.Life NA 563.1 hours 1compartment NA NA Rat Human -DTXSID2034881 Css NA 79.67 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034881 Css NA 193.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034881 Css NA 52.05 mg/L PBTK NA 50% Rat Human -DTXSID2034881 Css NA 114.5 mg/L PBTK NA 95% Rat Human -DTXSID2034885 Clint NA 53.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034885 Fup NA 0.0126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034885 Vd NA 2.927 L/kg 1compartment NA NA Human Human -DTXSID2034885 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2034885 TK.Half.Life NA 26.66 hours 1compartment NA NA Human Human -DTXSID2034885 Css NA 1.124 mg/L 3compartmentss NA 50% Human Human -DTXSID2034885 Css NA 7.172 mg/L 3compartmentss NA 95% Human Human -DTXSID2034885 Css NA 0.763 mg/L PBTK NA 50% Human Human -DTXSID2034885 Css NA 4.798 mg/L PBTK NA 95% Human Human -DTXSID2034885 Clint NA 53.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034885 Fup NA 0.0126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034885 Vd NA 2.189 L/kg 1compartment NA NA Rat Human -DTXSID2034885 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2034885 TK.Half.Life NA 4.81 hours 1compartment NA NA Rat Human -DTXSID2034885 Css NA 0.637 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034885 Css NA 3.539 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034885 Css NA 0.4135 mg/L PBTK NA 50% Rat Human -DTXSID2034885 Css NA 2.217 mg/L PBTK NA 95% Rat Human +DTXSID2034881 Fup 0.00853 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034881 Vd NA 1.921 L/kg 1compartment NA NA Rat Human +DTXSID2034881 Days.Css NA 512 Days PBTK NA NA Rat Human +DTXSID2034881 TK.Half.Life NA 829.6 hours 1compartment NA NA Rat Human +DTXSID2034881 Css NA 24.06 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034881 Css NA 72.23 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034881 Css NA 15.65 mg/L PBTK NA 50% Rat Human +DTXSID2034881 Css NA 42.77 mg/L PBTK NA 95% Rat Human +DTXSID2034885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034885 Fup 0.01 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2034885 Vd NA 2.876 L/kg 1compartment NA NA Human Human +DTXSID2034885 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID2034885 TK.Half.Life NA 62.5 hours 1compartment NA NA Human Human +DTXSID2034885 Css NA 2.805 mg/L 3compartmentss NA 50% Human Human +DTXSID2034885 Css NA 19.21 mg/L 3compartmentss NA 95% Human Human +DTXSID2034885 Css NA 1.904 mg/L PBTK NA 50% Human Human +DTXSID2034885 Css NA 12.58 mg/L PBTK NA 95% Human Human +DTXSID2034885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034885 Fup 0.01 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2034885 Vd NA 2.151 L/kg 1compartment NA NA Rat Human +DTXSID2034885 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID2034885 TK.Half.Life NA 11.27 hours 1compartment NA NA Rat Human +DTXSID2034885 Css NA 0.3646 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034885 Css NA 2.154 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034885 Css NA 0.2438 mg/L PBTK NA 50% Rat Human +DTXSID2034885 Css NA 1.42 mg/L PBTK NA 95% Rat Human DTXSID2034962 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2034962 Fup 0.8286 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID2034962 Vd NA 0.5607 L/kg 1compartment NA NA Human Human +DTXSID2034962 Vd NA 0.56 L/kg 1compartment NA NA Human Human DTXSID2034962 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2034962 TK.Half.Life NA 4.379 hours 1compartment NA NA Human Human -DTXSID2034962 Css NA 1.028 mg/L 3compartmentss NA 50% Human Human -DTXSID2034962 Css NA 5.736 mg/L 3compartmentss NA 95% Human Human -DTXSID2034962 Css NA 0.803 mg/L PBTK NA 50% Human Human -DTXSID2034962 Css NA 3.645 mg/L PBTK NA 95% Human Human +DTXSID2034962 TK.Half.Life NA 4.373 hours 1compartment NA NA Human Human +DTXSID2034962 Css NA 0.9812 mg/L 3compartmentss NA 50% Human Human +DTXSID2034962 Css NA 5.756 mg/L 3compartmentss NA 95% Human Human +DTXSID2034962 Css NA 0.7688 mg/L PBTK NA 50% Human Human +DTXSID2034962 Css NA 3.641 mg/L PBTK NA 95% Human Human DTXSID2034962 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2034962 Fup 0.8286 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID2034962 Vd NA 0.5806 L/kg 1compartment NA NA Rat Human +DTXSID2034962 Vd NA 0.5799 L/kg 1compartment NA NA Rat Human DTXSID2034962 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034962 TK.Half.Life NA 1.545 hours 1compartment NA NA Rat Human -DTXSID2034962 Css NA 0.2656 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034962 Css NA 1.459 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034962 Css NA 0.2001 mg/L PBTK NA 50% Rat Human -DTXSID2034962 Css NA 0.8601 mg/L PBTK NA 95% Rat Human +DTXSID2034962 TK.Half.Life NA 1.543 hours 1compartment NA NA Rat Human +DTXSID2034962 Css NA 0.05701 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034962 Css NA 0.3251 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034962 Css NA 0.04468 mg/L PBTK NA 50% Rat Human +DTXSID2034962 Css NA 0.1985 mg/L PBTK NA 95% Rat Human DTXSID2034968 Clint NA 1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2034968 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2034968 Vd NA 0.884 L/kg 1compartment NA NA Human Human +DTXSID2034968 Vd NA 0.9751 L/kg 1compartment NA NA Human Human DTXSID2034968 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2034968 TK.Half.Life NA 2.353 hours 1compartment NA NA Human Human -DTXSID2034968 Css NA 0.305 mg/L 3compartmentss NA 50% Human Human -DTXSID2034968 Css NA 2.127 mg/L 3compartmentss NA 95% Human Human -DTXSID2034968 Css NA 0.2629 mg/L PBTK NA 50% Human Human -DTXSID2034968 Css NA 1.447 mg/L PBTK NA 95% Human Human +DTXSID2034968 TK.Half.Life NA 2.602 hours 1compartment NA NA Human Human +DTXSID2034968 Css NA 0.2528 mg/L 3compartmentss NA 50% Human Human +DTXSID2034968 Css NA 1.668 mg/L 3compartmentss NA 95% Human Human +DTXSID2034968 Css NA 0.222 mg/L PBTK NA 50% Human Human +DTXSID2034968 Css NA 1.153 mg/L PBTK NA 95% Human Human DTXSID2034968 Clint NA 1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2034968 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2034968 Vd NA 0.907 L/kg 1compartment NA NA Rat Human +DTXSID2034968 Vd NA 0.9824 L/kg 1compartment NA NA Rat Human DTXSID2034968 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2034968 TK.Half.Life NA 1.154 hours 1compartment NA NA Rat Human -DTXSID2034968 Css NA 0.1144 mg/L 3compartmentss NA 50% Rat Human -DTXSID2034968 Css NA 0.7373 mg/L 3compartmentss NA 95% Rat Human -DTXSID2034968 Css NA 0.09774 mg/L PBTK NA 50% Rat Human -DTXSID2034968 Css NA 0.4479 mg/L PBTK NA 95% Rat Human -DTXSID2035013 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2035013 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2035013 Vd NA 2.08 L/kg 1compartment NA NA Human Human -DTXSID2035013 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2035013 TK.Half.Life NA 18.98 hours 1compartment NA NA Human Human -DTXSID2035013 Css NA 0.7882 mg/L 3compartmentss NA 50% Human Human -DTXSID2035013 Css NA 5.679 mg/L 3compartmentss NA 95% Human Human -DTXSID2035013 Css NA 0.796 mg/L PBTK NA 50% Human Human -DTXSID2035013 Css NA 3.996 mg/L PBTK NA 95% Human Human -DTXSID2035013 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2035013 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2035013 Vd NA 1.778 L/kg 1compartment NA NA Rat Human -DTXSID2035013 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2035013 TK.Half.Life NA 4.303 hours 1compartment NA NA Rat Human -DTXSID2035013 Css NA 0.2041 mg/L 3compartmentss NA 50% Rat Human -DTXSID2035013 Css NA 1.316 mg/L 3compartmentss NA 95% Rat Human -DTXSID2035013 Css NA 0.2033 mg/L PBTK NA 50% Rat Human -DTXSID2035013 Css NA 0.8534 mg/L PBTK NA 95% Rat Human -DTXSID2035481 Clint NA 12.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2035481 Fup NA 0.2447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2035481 Vd NA 1.818 L/kg 1compartment NA NA Human Human +DTXSID2034968 TK.Half.Life NA 1.249 hours 1compartment NA NA Rat Human +DTXSID2034968 Css NA 0.006533 mg/L 3compartmentss NA 50% Rat Human +DTXSID2034968 Css NA 0.05842 mg/L 3compartmentss NA 95% Rat Human +DTXSID2034968 Css NA 0.005596 mg/L PBTK NA 50% Rat Human +DTXSID2034968 Css NA 0.03965 mg/L PBTK NA 95% Rat Human +DTXSID2035481 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2035481 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2035481 Vd NA 1.302 L/kg 1compartment NA NA Human Human DTXSID2035481 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2035481 TK.Half.Life NA 4.327 hours 1compartment NA NA Human Human -DTXSID2035481 Css NA 0.2005 mg/L 3compartmentss NA 50% Human Human -DTXSID2035481 Css NA 1.27 mg/L 3compartmentss NA 95% Human Human -DTXSID2035481 Css NA 0.1488 mg/L PBTK NA 50% Human Human -DTXSID2035481 Css NA 0.8758 mg/L PBTK NA 95% Human Human -DTXSID2035481 Clint NA 12.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2035481 Fup NA 0.2447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2035481 Vd NA 1.424 L/kg 1compartment NA NA Rat Human +DTXSID2035481 TK.Half.Life NA 2.109 hours 1compartment NA NA Human Human +DTXSID2035481 Css NA 0.1034 mg/L 3compartmentss NA 50% Human Human +DTXSID2035481 Css NA 0.7286 mg/L 3compartmentss NA 95% Human Human +DTXSID2035481 Css NA 0.07458 mg/L PBTK NA 50% Human Human +DTXSID2035481 Css NA 0.4869 mg/L PBTK NA 95% Human Human +DTXSID2035481 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2035481 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2035481 Vd NA 1.048 L/kg 1compartment NA NA Rat Human DTXSID2035481 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2035481 TK.Half.Life NA 1.577 hours 1compartment NA NA Rat Human -DTXSID2035481 Css NA 0.107 mg/L 3compartmentss NA 50% Rat Human -DTXSID2035481 Css NA 0.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID2035481 Css NA 0.0762 mg/L PBTK NA 50% Rat Human -DTXSID2035481 Css NA 0.3318 mg/L PBTK NA 95% Rat Human -DTXSID2036112 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2036112 Fup NA 0.0394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2036112 Vd NA 3.192 L/kg 1compartment NA NA Human Human +DTXSID2035481 TK.Half.Life NA 0.8662 hours 1compartment NA NA Rat Human +DTXSID2035481 Css NA 0.01316 mg/L 3compartmentss NA 50% Rat Human +DTXSID2035481 Css NA 0.07158 mg/L 3compartmentss NA 95% Rat Human +DTXSID2035481 Css NA 0.00945 mg/L PBTK NA 50% Rat Human +DTXSID2035481 Css NA 0.04746 mg/L PBTK NA 95% Rat Human +DTXSID2036112 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2036112 Fup 0.0752 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2036112 Vd NA 2.378 L/kg 1compartment NA NA Human Human DTXSID2036112 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2036112 TK.Half.Life NA 6.406 hours 1compartment NA NA Human Human -DTXSID2036112 Css NA 0.1731 mg/L 3compartmentss NA 50% Human Human -DTXSID2036112 Css NA 1.431 mg/L 3compartmentss NA 95% Human Human -DTXSID2036112 Css NA 0.1369 mg/L PBTK NA 50% Human Human -DTXSID2036112 Css NA 1.032 mg/L PBTK NA 95% Human Human -DTXSID2036112 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2036112 Fup NA 0.0394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2036112 Vd NA 2.7 L/kg 1compartment NA NA Rat Human +DTXSID2036112 TK.Half.Life NA 4.764 hours 1compartment NA NA Human Human +DTXSID2036112 Css NA 0.1733 mg/L 3compartmentss NA 50% Human Human +DTXSID2036112 Css NA 1.559 mg/L 3compartmentss NA 95% Human Human +DTXSID2036112 Css NA 0.1441 mg/L PBTK NA 50% Human Human +DTXSID2036112 Css NA 1.095 mg/L PBTK NA 95% Human Human +DTXSID2036112 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2036112 Fup 0.0752 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2036112 Vd NA 2.312 L/kg 1compartment NA NA Rat Human DTXSID2036112 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2036112 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human -DTXSID2036112 Css NA 0.09738 mg/L 3compartmentss NA 50% Rat Human -DTXSID2036112 Css NA 0.6703 mg/L 3compartmentss NA 95% Rat Human -DTXSID2036112 Css NA 0.0739 mg/L PBTK NA 50% Rat Human -DTXSID2036112 Css NA 0.4604 mg/L PBTK NA 95% Rat Human +DTXSID2036112 TK.Half.Life NA 2.679 hours 1compartment NA NA Rat Human +DTXSID2036112 Css NA 0.02262 mg/L 3compartmentss NA 50% Rat Human +DTXSID2036112 Css NA 0.1596 mg/L 3compartmentss NA 95% Rat Human +DTXSID2036112 Css NA 0.01858 mg/L PBTK NA 50% Rat Human +DTXSID2036112 Css NA 0.112 mg/L PBTK NA 95% Rat Human DTXSID2036409 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2036409 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2036409 Vd NA 0.9122 L/kg 1compartment NA NA Human Human +DTXSID2036409 Vd NA 0.6873 L/kg 1compartment NA NA Human Human DTXSID2036409 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2036409 TK.Half.Life NA 5.904 hours 1compartment NA NA Human Human -DTXSID2036409 Css NA 0.8136 mg/L 3compartmentss NA 50% Human Human -DTXSID2036409 Css NA 5.506 mg/L 3compartmentss NA 95% Human Human -DTXSID2036409 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID2036409 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID2036409 TK.Half.Life NA 4.449 hours 1compartment NA NA Human Human +DTXSID2036409 Css NA 0.7152 mg/L 3compartmentss NA 50% Human Human +DTXSID2036409 Css NA 5.072 mg/L 3compartmentss NA 95% Human Human +DTXSID2036409 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID2036409 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID2036409 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2036409 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2036409 Vd NA 0.9526 L/kg 1compartment NA NA Rat Human +DTXSID2036409 Vd NA 0.74 L/kg 1compartment NA NA Rat Human DTXSID2036409 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2036409 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human -DTXSID2036409 Css NA 0.2038 mg/L 3compartmentss NA 50% Rat Human -DTXSID2036409 Css NA 1.321 mg/L 3compartmentss NA 95% Rat Human -DTXSID2036409 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID2036409 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID2036588 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2036588 Fup NA 0.0224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2036588 Vd NA 3.065 L/kg 1compartment NA NA Human Human -DTXSID2036588 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID2036588 TK.Half.Life NA 24360 hours 1compartment NA NA Human Human -DTXSID2036588 Css NA 933.2 mg/L 3compartmentss NA 50% Human Human -DTXSID2036588 Css NA 2625 mg/L 3compartmentss NA 95% Human Human -DTXSID2036588 Css NA 648.4 mg/L PBTK NA 50% Human Human -DTXSID2036588 Css NA 1689 mg/L PBTK NA 95% Human Human -DTXSID2036588 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2036588 Fup NA 0.0224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2036588 Vd NA 2.296 L/kg 1compartment NA NA Rat Human -DTXSID2036588 Days.Css NA 1712 Days PBTK NA NA Rat Human -DTXSID2036588 TK.Half.Life NA 1654 hours 1compartment NA NA Rat Human -DTXSID2036588 Css NA 253.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID2036588 Css NA 576.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID2036588 Css NA 167.7 mg/L PBTK NA 50% Rat Human -DTXSID2036588 Css NA 345.2 mg/L PBTK NA 95% Rat Human -DTXSID2036827 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2036827 Fup NA 0.3389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2036827 Vd NA 1.431 L/kg 1compartment NA NA Human Human -DTXSID2036827 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2036827 TK.Half.Life NA 33.76 hours 1compartment NA NA Human Human -DTXSID2036827 Css NA 2.52 mg/L 3compartmentss NA 50% Human Human -DTXSID2036827 Css NA 9.947 mg/L 3compartmentss NA 95% Human Human -DTXSID2036827 Css NA 1.958 mg/L PBTK NA 50% Human Human -DTXSID2036827 Css NA 6.578 mg/L PBTK NA 95% Human Human -DTXSID2036827 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2036827 Fup NA 0.3389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2036827 Vd NA 1.176 L/kg 1compartment NA NA Rat Human +DTXSID2036409 TK.Half.Life NA 1.631 hours 1compartment NA NA Rat Human +DTXSID2036409 Css NA 0.01313 mg/L 3compartmentss NA 50% Rat Human +DTXSID2036409 Css NA 0.1003 mg/L 3compartmentss NA 95% Rat Human +DTXSID2036409 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID2036409 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID2036827 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2036827 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2036827 Vd NA 0.4882 L/kg 1compartment NA NA Human Human +DTXSID2036827 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2036827 TK.Half.Life NA 1.227 hours 1compartment NA NA Human Human +DTXSID2036827 Css NA 0.2206 mg/L 3compartmentss NA 50% Human Human +DTXSID2036827 Css NA 1.445 mg/L 3compartmentss NA 95% Human Human +DTXSID2036827 Css NA 0.1532 mg/L PBTK NA 50% Human Human +DTXSID2036827 Css NA 0.9324 mg/L PBTK NA 95% Human Human +DTXSID2036827 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2036827 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2036827 Vd NA 0.4888 L/kg 1compartment NA NA Rat Human DTXSID2036827 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2036827 TK.Half.Life NA 8.079 hours 1compartment NA NA Rat Human -DTXSID2036827 Css NA 0.6878 mg/L 3compartmentss NA 50% Rat Human -DTXSID2036827 Css NA 2.214 mg/L 3compartmentss NA 95% Rat Human -DTXSID2036827 Css NA 0.5123 mg/L PBTK NA 50% Rat Human -DTXSID2036827 Css NA 1.366 mg/L PBTK NA 95% Rat Human -DTXSID2037186 Clint NA 30.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2037186 Fup NA 0.0233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2037186 Vd NA 0.4407 L/kg 1compartment NA NA Human Human -DTXSID2037186 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2037186 TK.Half.Life NA 2.643 hours 1compartment NA NA Human Human -DTXSID2037186 Css NA 0.9568 mg/L 3compartmentss NA 50% Human Human -DTXSID2037186 Css NA 9.774 mg/L 3compartmentss NA 95% Human Human -DTXSID2037186 Css NA 0.5692 mg/L PBTK NA 50% Human Human -DTXSID2037186 Css NA 5.734 mg/L PBTK NA 95% Human Human -DTXSID2037186 Clint NA 30.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2037186 Fup NA 0.0233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2037186 Vd NA 0.3494 L/kg 1compartment NA NA Rat Human -DTXSID2037186 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2037186 TK.Half.Life NA 1.331 hours 1compartment NA NA Rat Human -DTXSID2037186 Css NA 0.5526 mg/L 3compartmentss NA 50% Rat Human -DTXSID2037186 Css NA 4.417 mg/L 3compartmentss NA 95% Rat Human -DTXSID2037186 Css NA 0.3059 mg/L PBTK NA 50% Rat Human -DTXSID2037186 Css NA 2.41 mg/L PBTK NA 95% Rat Human -DTXSID2037502 Clint NA 26.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2037502 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2037502 Vd NA 2.656 L/kg 1compartment NA NA Human Human -DTXSID2037502 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2037502 TK.Half.Life NA 24.03 hours 1compartment NA NA Human Human -DTXSID2037502 Css NA 1.207 mg/L 3compartmentss NA 50% Human Human -DTXSID2037502 Css NA 8.421 mg/L 3compartmentss NA 95% Human Human -DTXSID2037502 Css NA 0.8079 mg/L PBTK NA 50% Human Human -DTXSID2037502 Css NA 5.376 mg/L PBTK NA 95% Human Human -DTXSID2037502 Clint NA 26.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2037502 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2037502 Vd NA 1.986 L/kg 1compartment NA NA Rat Human -DTXSID2037502 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2037502 TK.Half.Life NA 5.428 hours 1compartment NA NA Rat Human -DTXSID2037502 Css NA 0.6766 mg/L 3compartmentss NA 50% Rat Human -DTXSID2037502 Css NA 3.863 mg/L 3compartmentss NA 95% Rat Human -DTXSID2037502 Css NA 0.432 mg/L PBTK NA 50% Rat Human -DTXSID2037502 Css NA 2.353 mg/L PBTK NA 95% Rat Human +DTXSID2036827 TK.Half.Life NA 0.6989 hours 1compartment NA NA Rat Human +DTXSID2036827 Css NA 0.02648 mg/L 3compartmentss NA 50% Rat Human +DTXSID2036827 Css NA 0.1208 mg/L 3compartmentss NA 95% Rat Human +DTXSID2036827 Css NA 0.01818 mg/L PBTK NA 50% Rat Human +DTXSID2036827 Css NA 0.07508 mg/L PBTK NA 95% Rat Human +DTXSID2037186 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2037186 Fup 0.0821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2037186 Vd NA 3.072 L/kg 1compartment NA NA Human Human +DTXSID2037186 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID2037186 TK.Half.Life NA 151.1 hours 1compartment NA NA Human Human +DTXSID2037186 Css NA 5.924 mg/L 3compartmentss NA 50% Human Human +DTXSID2037186 Css NA 35.66 mg/L 3compartmentss NA 95% Human Human +DTXSID2037186 Css NA 4.126 mg/L PBTK NA 50% Human Human +DTXSID2037186 Css NA 23.58 mg/L PBTK NA 95% Human Human +DTXSID2037186 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2037186 Fup 0.0821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2037186 Vd NA 2.305 L/kg 1compartment NA NA Rat Human +DTXSID2037186 Days.Css NA 15 Days PBTK NA NA Rat Human +DTXSID2037186 TK.Half.Life NA 21.12 hours 1compartment NA NA Rat Human +DTXSID2037186 Css NA 0.7538 mg/L 3compartmentss NA 50% Rat Human +DTXSID2037186 Css NA 3.599 mg/L 3compartmentss NA 95% Rat Human +DTXSID2037186 Css NA 0.518 mg/L PBTK NA 50% Rat Human +DTXSID2037186 Css NA 2.452 mg/L PBTK NA 95% Rat Human +DTXSID2037502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2037502 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2037502 Vd NA 2.084 L/kg 1compartment NA NA Human Human +DTXSID2037502 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2037502 TK.Half.Life NA 32.02 hours 1compartment NA NA Human Human +DTXSID2037502 Css NA 2.336 mg/L 3compartmentss NA 50% Human Human +DTXSID2037502 Css NA 19.74 mg/L 3compartmentss NA 95% Human Human +DTXSID2037502 Css NA 1.51 mg/L PBTK NA 50% Human Human +DTXSID2037502 Css NA 12.06 mg/L PBTK NA 95% Human Human +DTXSID2037502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2037502 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2037502 Vd NA 1.546 L/kg 1compartment NA NA Rat Human +DTXSID2037502 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2037502 TK.Half.Life NA 9.877 hours 1compartment NA NA Rat Human +DTXSID2037502 Css NA 0.3026 mg/L 3compartmentss NA 50% Rat Human +DTXSID2037502 Css NA 2.085 mg/L 3compartmentss NA 95% Rat Human +DTXSID2037502 Css NA 0.1891 mg/L PBTK NA 50% Rat Human +DTXSID2037502 Css NA 1.261 mg/L PBTK NA 95% Rat Human DTXSID2037712 Clint 30.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2037712 Fup 0.0141 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2037712 Vd NA 1.059 L/kg 1compartment NA NA Human Human -DTXSID2037712 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2037712 TK.Half.Life NA 9.008 hours 1compartment NA NA Human Human -DTXSID2037712 Css NA 0.962 mg/L 3compartmentss NA 50% Human Human -DTXSID2037712 Css NA 7.154 mg/L 3compartmentss NA 95% Human Human -DTXSID2037712 Css NA 0.5944 mg/L PBTK NA 50% Human Human -DTXSID2037712 Css NA 4.306 mg/L PBTK NA 95% Human Human +DTXSID2037712 Vd NA 1.855 L/kg 1compartment NA NA Human Human +DTXSID2037712 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2037712 TK.Half.Life NA 16.74 hours 1compartment NA NA Human Human +DTXSID2037712 Css NA 1.018 mg/L 3compartmentss NA 50% Human Human +DTXSID2037712 Css NA 6.871 mg/L 3compartmentss NA 95% Human Human +DTXSID2037712 Css NA 0.6604 mg/L PBTK NA 50% Human Human +DTXSID2037712 Css NA 4.268 mg/L PBTK NA 95% Human Human DTXSID2037712 Clint 30.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2037712 Fup 0.0141 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2037712 Vd NA 0.7842 L/kg 1compartment NA NA Rat Human +DTXSID2037712 Vd NA 1.375 L/kg 1compartment NA NA Rat Human DTXSID2037712 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2037712 TK.Half.Life NA 3.894 hours 1compartment NA NA Rat Human -DTXSID2037712 Css NA 0.5523 mg/L 3compartmentss NA 50% Rat Human -DTXSID2037712 Css NA 3.178 mg/L 3compartmentss NA 95% Rat Human -DTXSID2037712 Css NA 0.3194 mg/L PBTK NA 50% Rat Human -DTXSID2037712 Css NA 1.8 mg/L PBTK NA 95% Rat Human +DTXSID2037712 TK.Half.Life NA 5.719 hours 1compartment NA NA Rat Human +DTXSID2037712 Css NA 0.1306 mg/L 3compartmentss NA 50% Rat Human +DTXSID2037712 Css NA 0.7528 mg/L 3compartmentss NA 95% Rat Human +DTXSID2037712 Css NA 0.0828 mg/L PBTK NA 50% Rat Human +DTXSID2037712 Css NA 0.4699 mg/L PBTK NA 95% Rat Human DTXSID2037714 Clint 42.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2037714 Fup 0.00365 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2037714 Vd NA 1.219 L/kg 1compartment NA NA Human Human DTXSID2037714 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID2037714 TK.Half.Life NA 19.07 hours 1compartment NA NA Human Human -DTXSID2037714 Css NA 1.792 mg/L 3compartmentss NA 50% Human Human -DTXSID2037714 Css NA 12.9 mg/L 3compartmentss NA 95% Human Human -DTXSID2037714 Css NA 1.101 mg/L PBTK NA 50% Human Human -DTXSID2037714 Css NA 7.842 mg/L PBTK NA 95% Human Human +DTXSID2037714 Css NA 1.714 mg/L 3compartmentss NA 50% Human Human +DTXSID2037714 Css NA 13.56 mg/L 3compartmentss NA 95% Human Human +DTXSID2037714 Css NA 1.057 mg/L PBTK NA 50% Human Human +DTXSID2037714 Css NA 8.141 mg/L PBTK NA 95% Human Human DTXSID2037714 Clint 42.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2037714 Fup 0.00365 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2037714 Vd NA 0.8927 L/kg 1compartment NA NA Rat Human DTXSID2037714 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2037714 TK.Half.Life NA 7.974 hours 1compartment NA NA Rat Human -DTXSID2037714 Css NA 0.9956 mg/L 3compartmentss NA 50% Rat Human -DTXSID2037714 Css NA 6.241 mg/L 3compartmentss NA 95% Rat Human -DTXSID2037714 Css NA 0.5769 mg/L PBTK NA 50% Rat Human -DTXSID2037714 Css NA 3.554 mg/L PBTK NA 95% Rat Human -DTXSID2038732 Clint NA 51.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2038732 Fup NA 0.6881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2038732 Vd NA 1.218 L/kg 1compartment NA NA Human Human +DTXSID2037714 Css NA 0.2256 mg/L 3compartmentss NA 50% Rat Human +DTXSID2037714 Css NA 1.394 mg/L 3compartmentss NA 95% Rat Human +DTXSID2037714 Css NA 0.1352 mg/L PBTK NA 50% Rat Human +DTXSID2037714 Css NA 0.8181 mg/L PBTK NA 95% Rat Human +DTXSID2038443 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2038443 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2038443 Vd NA 1.503 L/kg 1compartment NA NA Human Human +DTXSID2038443 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2038443 TK.Half.Life NA 7.533 hours 1compartment NA NA Human Human +DTXSID2038443 Css NA 0.456 mg/L 3compartmentss NA 50% Human Human +DTXSID2038443 Css NA 2.9 mg/L 3compartmentss NA 95% Human Human +DTXSID2038443 Css NA 0.4554 mg/L PBTK NA 50% Human Human +DTXSID2038443 Css NA 2.899 mg/L PBTK NA 95% Human Human +DTXSID2038443 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2038443 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2038443 Vd NA 4.062 L/kg 1compartment NA NA Rat Human +DTXSID2038443 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2038443 TK.Half.Life NA 2.98 hours 1compartment NA NA Rat Human +DTXSID2038443 Css NA 0.01064 mg/L 3compartmentss NA 50% Rat Human +DTXSID2038443 Css NA 0.06046 mg/L 3compartmentss NA 95% Rat Human +DTXSID2038443 Css NA 0.01103 mg/L PBTK NA 50% Rat Human +DTXSID2038443 Css NA 0.06255 mg/L PBTK NA 95% Rat Human +DTXSID2038732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2038732 Fup 0.556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2038732 Vd NA 1.075 L/kg 1compartment NA NA Human Human DTXSID2038732 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2038732 TK.Half.Life NA 0.8342 hours 1compartment NA NA Human Human -DTXSID2038732 Css NA 0.0133 mg/L 3compartmentss NA 50% Human Human -DTXSID2038732 Css NA 0.1454 mg/L 3compartmentss NA 95% Human Human -DTXSID2038732 Css NA 0.01142 mg/L PBTK NA 50% Human Human -DTXSID2038732 Css NA 0.1054 mg/L PBTK NA 95% Human Human -DTXSID2038732 Clint NA 51.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2038732 Fup NA 0.6881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2038732 Vd NA 1.112 L/kg 1compartment NA NA Rat Human +DTXSID2038732 TK.Half.Life NA 0.9948 hours 1compartment NA NA Human Human +DTXSID2038732 Css NA 0.03498 mg/L 3compartmentss NA 50% Human Human +DTXSID2038732 Css NA 0.3781 mg/L 3compartmentss NA 95% Human Human +DTXSID2038732 Css NA 0.02884 mg/L PBTK NA 50% Human Human +DTXSID2038732 Css NA 0.258 mg/L PBTK NA 95% Human Human +DTXSID2038732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2038732 Fup 0.556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2038732 Vd NA 0.9801 L/kg 1compartment NA NA Rat Human DTXSID2038732 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2038732 TK.Half.Life NA 0.3503 hours 1compartment NA NA Rat Human -DTXSID2038732 Css NA 0.006896 mg/L 3compartmentss NA 50% Rat Human -DTXSID2038732 Css NA 0.07125 mg/L 3compartmentss NA 95% Rat Human -DTXSID2038732 Css NA 0.005883 mg/L PBTK NA 50% Rat Human -DTXSID2038732 Css NA 0.04758 mg/L PBTK NA 95% Rat Human +DTXSID2038732 TK.Half.Life NA 0.4489 hours 1compartment NA NA Rat Human +DTXSID2038732 Css NA 0.00422 mg/L 3compartmentss NA 50% Rat Human +DTXSID2038732 Css NA 0.03959 mg/L 3compartmentss NA 95% Rat Human +DTXSID2038732 Css NA 0.003508 mg/L PBTK NA 50% Rat Human +DTXSID2038732 Css NA 0.02589 mg/L PBTK NA 95% Rat Human DTXSID2038788 Clint NA 0.1183 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2038788 Fup NA 0.5727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2038788 Vd NA 0.5305 L/kg 1compartment NA NA Human Human +DTXSID2038788 Vd NA 0.5902 L/kg 1compartment NA NA Human Human DTXSID2038788 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2038788 TK.Half.Life NA 5.008 hours 1compartment NA NA Human Human -DTXSID2038788 Css NA 1.079 mg/L 3compartmentss NA 50% Human Human -DTXSID2038788 Css NA 6.916 mg/L 3compartmentss NA 95% Human Human -DTXSID2038788 Css NA 0.832 mg/L PBTK NA 50% Human Human -DTXSID2038788 Css NA 4.296 mg/L PBTK NA 95% Human Human +DTXSID2038788 TK.Half.Life NA 5.581 hours 1compartment NA NA Human Human +DTXSID2038788 Css NA 1.005 mg/L 3compartmentss NA 50% Human Human +DTXSID2038788 Css NA 6.514 mg/L 3compartmentss NA 95% Human Human +DTXSID2038788 Css NA 0.8049 mg/L PBTK NA 50% Human Human +DTXSID2038788 Css NA 4.1 mg/L PBTK NA 95% Human Human DTXSID2038788 Clint NA 0.1183 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2038788 Fup NA 0.5727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2038788 Vd NA 0.5388 L/kg 1compartment NA NA Rat Human +DTXSID2038788 Vd NA 0.5949 L/kg 1compartment NA NA Rat Human DTXSID2038788 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2038788 TK.Half.Life NA 1.893 hours 1compartment NA NA Rat Human -DTXSID2038788 Css NA 0.3186 mg/L 3compartmentss NA 50% Rat Human -DTXSID2038788 Css NA 2.115 mg/L 3compartmentss NA 95% Rat Human -DTXSID2038788 Css NA 0.2343 mg/L PBTK NA 50% Rat Human -DTXSID2038788 Css NA 1.224 mg/L PBTK NA 95% Rat Human -DTXSID2038813 Clint NA 5.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2038813 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2038813 Vd NA 0.8443 L/kg 1compartment NA NA Human Human +DTXSID2038788 TK.Half.Life NA 2.092 hours 1compartment NA NA Rat Human +DTXSID2038788 Css NA 0.06918 mg/L 3compartmentss NA 50% Rat Human +DTXSID2038788 Css NA 0.4484 mg/L 3compartmentss NA 95% Rat Human +DTXSID2038788 Css NA 0.05451 mg/L PBTK NA 50% Rat Human +DTXSID2038788 Css NA 0.271 mg/L PBTK NA 95% Rat Human +DTXSID2038813 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2038813 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2038813 Vd NA 0.6353 L/kg 1compartment NA NA Human Human DTXSID2038813 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2038813 TK.Half.Life NA 0.9358 hours 1compartment NA NA Human Human -DTXSID2038813 Css NA 0.08774 mg/L 3compartmentss NA 50% Human Human -DTXSID2038813 Css NA 0.7933 mg/L 3compartmentss NA 95% Human Human -DTXSID2038813 Css NA 0.07394 mg/L PBTK NA 50% Human Human -DTXSID2038813 Css NA 0.5789 mg/L PBTK NA 95% Human Human -DTXSID2038813 Clint NA 5.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2038813 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2038813 Vd NA 0.8701 L/kg 1compartment NA NA Rat Human +DTXSID2038813 TK.Half.Life NA 6.639 hours 1compartment NA NA Human Human +DTXSID2038813 Css NA 1.187 mg/L 3compartmentss NA 50% Human Human +DTXSID2038813 Css NA 7.854 mg/L 3compartmentss NA 95% Human Human +DTXSID2038813 Css NA 0.9374 mg/L PBTK NA 50% Human Human +DTXSID2038813 Css NA 4.859 mg/L PBTK NA 95% Human Human +DTXSID2038813 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2038813 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2038813 Vd NA 0.6529 L/kg 1compartment NA NA Rat Human DTXSID2038813 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2038813 TK.Half.Life NA 0.5019 hours 1compartment NA NA Rat Human -DTXSID2038813 Css NA 0.04062 mg/L 3compartmentss NA 50% Rat Human -DTXSID2038813 Css NA 0.2981 mg/L 3compartmentss NA 95% Rat Human -DTXSID2038813 Css NA 0.03402 mg/L PBTK NA 50% Rat Human -DTXSID2038813 Css NA 0.1946 mg/L PBTK NA 95% Rat Human +DTXSID2038813 TK.Half.Life NA 2.322 hours 1compartment NA NA Rat Human +DTXSID2038813 Css NA 0.07178 mg/L 3compartmentss NA 50% Rat Human +DTXSID2038813 Css NA 0.4719 mg/L 3compartmentss NA 95% Rat Human +DTXSID2038813 Css NA 0.05611 mg/L PBTK NA 50% Rat Human +DTXSID2038813 Css NA 0.2849 mg/L PBTK NA 95% Rat Human +DTXSID2038817 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2038817 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2038817 Vd NA 4 L/kg 1compartment NA NA Human Human +DTXSID2038817 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID2038817 TK.Half.Life NA 88.77 hours 1compartment NA NA Human Human +DTXSID2038817 Css NA 1.344 mg/L 3compartmentss NA 50% Human Human +DTXSID2038817 Css NA 6.97 mg/L 3compartmentss NA 95% Human Human +DTXSID2038817 Css NA 1.763 mg/L PBTK NA 50% Human Human +DTXSID2038817 Css NA 6.088 mg/L PBTK NA 95% Human Human +DTXSID2038817 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2038817 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2038817 Vd NA 4.054 L/kg 1compartment NA NA Rat Human +DTXSID2038817 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID2038817 TK.Half.Life NA 30.01 hours 1compartment NA NA Rat Human +DTXSID2038817 Css NA 0.08128 mg/L 3compartmentss NA 50% Rat Human +DTXSID2038817 Css NA 0.3788 mg/L 3compartmentss NA 95% Rat Human +DTXSID2038817 Css NA 0.1114 mg/L PBTK NA 50% Rat Human +DTXSID2038817 Css NA 0.3194 mg/L PBTK NA 95% Rat Human DTXSID2039336 Clint 45.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2039336 Fup 2.31e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2039336 Vd NA 0.4993 L/kg 1compartment NA NA Human Human DTXSID2039336 Days.Css NA 18 Days PBTK NA NA Human Human DTXSID2039336 TK.Half.Life NA 83.69 hours 1compartment NA NA Human Human -DTXSID2039336 Css NA 6.804 mg/L 3compartmentss NA 50% Human Human -DTXSID2039336 Css NA 48.01 mg/L 3compartmentss NA 95% Human Human -DTXSID2039336 Css NA 7.264 mg/L PBTK NA 50% Human Human -DTXSID2039336 Css NA 45.69 mg/L PBTK NA 95% Human Human +DTXSID2039336 Css NA 7.985 mg/L 3compartmentss NA 50% Human Human +DTXSID2039336 Css NA 52.23 mg/L 3compartmentss NA 95% Human Human +DTXSID2039336 Css NA 7.184 mg/L PBTK NA 50% Human Human +DTXSID2039336 Css NA 46.99 mg/L PBTK NA 95% Human Human DTXSID2039336 Clint 134.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID2039336 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID2039336 Css NA 0.3123 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2039336 Css NA 2.043 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2039336 Css 0.0015 0.0497 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID2039336 Css 0.0015 0.3277 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat DTXSID2040151 Clint NA 16.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2040151 Fup NA 0.9136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040151 Vd NA 0.7016 L/kg 1compartment NA NA Human Human +DTXSID2040151 Vd NA 0.8707 L/kg 1compartment NA NA Human Human DTXSID2040151 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040151 TK.Half.Life NA 0.5635 hours 1compartment NA NA Human Human -DTXSID2040151 Css NA 0.03356 mg/L 3compartmentss NA 50% Human Human -DTXSID2040151 Css NA 0.2338 mg/L 3compartmentss NA 95% Human Human -DTXSID2040151 Css NA 0.02682 mg/L PBTK NA 50% Human Human -DTXSID2040151 Css NA 0.168 mg/L PBTK NA 95% Human Human +DTXSID2040151 TK.Half.Life NA 0.673 hours 1compartment NA NA Human Human +DTXSID2040151 Css NA 0.02386 mg/L 3compartmentss NA 50% Human Human +DTXSID2040151 Css NA 0.1989 mg/L 3compartmentss NA 95% Human Human +DTXSID2040151 Css NA 0.01995 mg/L PBTK NA 50% Human Human +DTXSID2040151 Css NA 0.1477 mg/L PBTK NA 95% Human Human DTXSID2040151 Clint NA 16.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2040151 Fup NA 0.9136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040151 Vd NA 0.7318 L/kg 1compartment NA NA Rat Human +DTXSID2040151 Vd NA 0.8861 L/kg 1compartment NA NA Rat Human DTXSID2040151 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040151 TK.Half.Life NA 0.286 hours 1compartment NA NA Rat Human -DTXSID2040151 Css NA 0.01682 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040151 Css NA 0.09784 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040151 Css NA 0.01332 mg/L PBTK NA 50% Rat Human -DTXSID2040151 Css NA 0.06913 mg/L PBTK NA 95% Rat Human -DTXSID2040234 Clint NA 12.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040234 Fup NA 0.1206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040234 Vd NA 0.8552 L/kg 1compartment NA NA Human Human +DTXSID2040151 TK.Half.Life NA 0.3355 hours 1compartment NA NA Rat Human +DTXSID2040151 Css NA 0.0008162 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040151 Css NA 0.00749 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040151 Css NA 0.0006843 mg/L PBTK NA 50% Rat Human +DTXSID2040151 Css NA 0.005512 mg/L PBTK NA 95% Rat Human +DTXSID2040234 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040234 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040234 Vd NA 0.8886 L/kg 1compartment NA NA Human Human DTXSID2040234 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040234 TK.Half.Life NA 2.736 hours 1compartment NA NA Human Human -DTXSID2040234 Css NA 0.3832 mg/L 3compartmentss NA 50% Human Human -DTXSID2040234 Css NA 2.919 mg/L 3compartmentss NA 95% Human Human -DTXSID2040234 Css NA 0.2502 mg/L PBTK NA 50% Human Human -DTXSID2040234 Css NA 1.791 mg/L PBTK NA 95% Human Human -DTXSID2040234 Clint NA 12.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040234 Fup NA 0.1206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040234 Vd NA 0.7095 L/kg 1compartment NA NA Rat Human +DTXSID2040234 TK.Half.Life NA 5.082 hours 1compartment NA NA Human Human +DTXSID2040234 Css NA 0.7595 mg/L 3compartmentss NA 50% Human Human +DTXSID2040234 Css NA 5.347 mg/L 3compartmentss NA 95% Human Human +DTXSID2040234 Css NA 0.4976 mg/L PBTK NA 50% Human Human +DTXSID2040234 Css NA 3.264 mg/L PBTK NA 95% Human Human +DTXSID2040234 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040234 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040234 Vd NA 0.7311 L/kg 1compartment NA NA Rat Human DTXSID2040234 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040234 TK.Half.Life NA 1.312 hours 1compartment NA NA Rat Human -DTXSID2040234 Css NA 0.2096 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040234 Css NA 1.225 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040234 Css NA 0.1302 mg/L PBTK NA 50% Rat Human -DTXSID2040234 Css NA 0.7129 mg/L PBTK NA 95% Rat Human -DTXSID2040236 Clint NA 1.374 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040236 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040236 Vd NA 0.5127 L/kg 1compartment NA NA Human Human +DTXSID2040234 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human +DTXSID2040234 Css NA 0.09312 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040234 Css NA 0.4808 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040234 Css NA 0.05934 mg/L PBTK NA 50% Rat Human +DTXSID2040234 Css NA 0.2854 mg/L PBTK NA 95% Rat Human +DTXSID2040236 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040236 Fup 0.606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040236 Vd NA 0.3952 L/kg 1compartment NA NA Human Human DTXSID2040236 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040236 TK.Half.Life NA 1.156 hours 1compartment NA NA Human Human -DTXSID2040236 Css NA 0.2825 mg/L 3compartmentss NA 50% Human Human -DTXSID2040236 Css NA 1.845 mg/L 3compartmentss NA 95% Human Human -DTXSID2040236 Css NA 0.2118 mg/L PBTK NA 50% Human Human -DTXSID2040236 Css NA 1.18 mg/L PBTK NA 95% Human Human -DTXSID2040236 Clint NA 1.374 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040236 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040236 Vd NA 0.536 L/kg 1compartment NA NA Rat Human +DTXSID2040236 TK.Half.Life NA 4.219 hours 1compartment NA NA Human Human +DTXSID2040236 Css NA 1.338 mg/L 3compartmentss NA 50% Human Human +DTXSID2040236 Css NA 8.297 mg/L 3compartmentss NA 95% Human Human +DTXSID2040236 Css NA 0.9482 mg/L PBTK NA 50% Human Human +DTXSID2040236 Css NA 5.032 mg/L PBTK NA 95% Human Human +DTXSID2040236 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040236 Fup 0.606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040236 Vd NA 0.4113 L/kg 1compartment NA NA Rat Human DTXSID2040236 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040236 TK.Half.Life NA 0.5965 hours 1compartment NA NA Rat Human -DTXSID2040236 Css NA 0.1121 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040236 Css NA 0.6483 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040236 Css NA 0.0824 mg/L PBTK NA 50% Rat Human -DTXSID2040236 Css NA 0.3788 mg/L PBTK NA 95% Rat Human -DTXSID2040284 Clint NA 12.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040284 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040284 Vd NA 0.2326 L/kg 1compartment NA NA Human Human -DTXSID2040284 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040284 TK.Half.Life NA 4.871 hours 1compartment NA NA Human Human -DTXSID2040284 Css NA 3.894 mg/L 3compartmentss NA 50% Human Human -DTXSID2040284 Css NA 35.32 mg/L 3compartmentss NA 95% Human Human -DTXSID2040284 Css NA 2.304 mg/L PBTK NA 50% Human Human -DTXSID2040284 Css NA 20.68 mg/L PBTK NA 95% Human Human -DTXSID2040284 Clint NA 12.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040284 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040284 Vd NA 0.2262 L/kg 1compartment NA NA Rat Human -DTXSID2040284 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040284 TK.Half.Life NA 3.119 hours 1compartment NA NA Rat Human -DTXSID2040284 Css NA 2.126 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040284 Css NA 15.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040284 Css NA 1.178 mg/L PBTK NA 50% Rat Human -DTXSID2040284 Css NA 8.608 mg/L PBTK NA 95% Rat Human +DTXSID2040236 TK.Half.Life NA 1.496 hours 1compartment NA NA Rat Human +DTXSID2040236 Css NA 0.082 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040236 Css NA 0.4808 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040236 Css NA 0.05736 mg/L PBTK NA 50% Rat Human +DTXSID2040236 Css NA 0.2826 mg/L PBTK NA 95% Rat Human +DTXSID2040284 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040284 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040284 Vd NA 0.3319 L/kg 1compartment NA NA Human Human +DTXSID2040284 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID2040284 TK.Half.Life NA 53.44 hours 1compartment NA NA Human Human +DTXSID2040284 Css NA 26.37 mg/L 3compartmentss NA 50% Human Human +DTXSID2040284 Css NA 150.3 mg/L 3compartmentss NA 95% Human Human +DTXSID2040284 Css NA 16.16 mg/L PBTK NA 50% Human Human +DTXSID2040284 Css NA 86.66 mg/L PBTK NA 95% Human Human +DTXSID2040284 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040284 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040284 Vd NA 0.3232 L/kg 1compartment NA NA Rat Human +DTXSID2040284 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2040284 TK.Half.Life NA 17.72 hours 1compartment NA NA Rat Human +DTXSID2040284 Css NA 1.711 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040284 Css NA 8.412 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040284 Css NA 1.018 mg/L PBTK NA 50% Rat Human +DTXSID2040284 Css NA 4.771 mg/L PBTK NA 95% Rat Human DTXSID2040361 Clint NA 1.893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2040361 Fup NA 0.9789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040361 Vd NA 1.142 L/kg 1compartment NA NA Human Human +DTXSID2040361 Vd NA 0.5531 L/kg 1compartment NA NA Human Human DTXSID2040361 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040361 TK.Half.Life NA 2.213 hours 1compartment NA NA Human Human -DTXSID2040361 Css NA 0.2054 mg/L 3compartmentss NA 50% Human Human -DTXSID2040361 Css NA 1.461 mg/L 3compartmentss NA 95% Human Human -DTXSID2040361 Css NA 0.1825 mg/L PBTK NA 50% Human Human -DTXSID2040361 Css NA 1.02 mg/L PBTK NA 95% Human Human +DTXSID2040361 TK.Half.Life NA 1.061 hours 1compartment NA NA Human Human +DTXSID2040361 Css NA 0.1912 mg/L 3compartmentss NA 50% Human Human +DTXSID2040361 Css NA 1.248 mg/L 3compartmentss NA 95% Human Human +DTXSID2040361 Css NA 0.1458 mg/L PBTK NA 50% Human Human +DTXSID2040361 Css NA 0.8178 mg/L PBTK NA 95% Human Human DTXSID2040361 Clint NA 1.893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2040361 Fup NA 0.9789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040361 Vd NA 1.114 L/kg 1compartment NA NA Rat Human +DTXSID2040361 Vd NA 0.5736 L/kg 1compartment NA NA Rat Human DTXSID2040361 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040361 TK.Half.Life NA 1.091 hours 1compartment NA NA Rat Human -DTXSID2040361 Css NA 0.08368 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040361 Css NA 0.5264 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040361 Css NA 0.07428 mg/L PBTK NA 50% Rat Human -DTXSID2040361 Css NA 0.3334 mg/L PBTK NA 95% Rat Human +DTXSID2040361 TK.Half.Life NA 0.559 hours 1compartment NA NA Rat Human +DTXSID2040361 Css NA 0.005862 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040361 Css NA 0.04855 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040361 Css NA 0.004337 mg/L PBTK NA 50% Rat Human +DTXSID2040361 Css NA 0.03146 mg/L PBTK NA 95% Rat Human DTXSID2040363 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2040363 Fup 0.01947 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID2040363 Vd NA 0.7725 L/kg 1compartment NA NA Human Human DTXSID2040363 Days.Css NA 62 Days PBTK NA NA Human Human DTXSID2040363 TK.Half.Life NA 257.8 hours 1compartment NA NA Human Human -DTXSID2040363 Css NA 52.17 mg/L 3compartmentss NA 50% Human Human -DTXSID2040363 Css NA 342.3 mg/L 3compartmentss NA 95% Human Human -DTXSID2040363 Css NA 33.88 mg/L PBTK NA 50% Human Human -DTXSID2040363 Css NA 203.2 mg/L PBTK NA 95% Human Human +DTXSID2040363 Css NA 50.76 mg/L 3compartmentss NA 50% Human Human +DTXSID2040363 Css NA 330.3 mg/L 3compartmentss NA 95% Human Human +DTXSID2040363 Css NA 33.04 mg/L PBTK NA 50% Human Human +DTXSID2040363 Css NA 196.3 mg/L PBTK NA 95% Human Human DTXSID2040363 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2040363 Fup 0.01947 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID2040363 Vd NA 0.7383 L/kg 1compartment NA NA Rat Human DTXSID2040363 Days.Css NA 17 Days PBTK NA NA Rat Human DTXSID2040363 TK.Half.Life NA 83.68 hours 1compartment NA NA Rat Human -DTXSID2040363 Css NA 14.93 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040363 Css NA 81.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040363 Css NA 9.059 mg/L PBTK NA 50% Rat Human -DTXSID2040363 Css NA 45.25 mg/L PBTK NA 95% Rat Human -DTXSID2040525 Clint NA 2.125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040525 Fup NA 0.0739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040525 Vd NA 0.636 L/kg 1compartment NA NA Human Human -DTXSID2040525 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2040525 TK.Half.Life NA 12.62 hours 1compartment NA NA Human Human -DTXSID2040525 Css NA 3.189 mg/L 3compartmentss NA 50% Human Human -DTXSID2040525 Css NA 18.13 mg/L 3compartmentss NA 95% Human Human -DTXSID2040525 Css NA 2 mg/L PBTK NA 50% Human Human -DTXSID2040525 Css NA 10.78 mg/L PBTK NA 95% Human Human -DTXSID2040525 Clint NA 2.125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040525 Fup NA 0.0739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040525 Vd NA 0.5179 L/kg 1compartment NA NA Rat Human +DTXSID2040363 Css NA 3.308 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040363 Css NA 19.08 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040363 Css NA 2.085 mg/L PBTK NA 50% Rat Human +DTXSID2040363 Css NA 10.93 mg/L PBTK NA 95% Rat Human +DTXSID2040446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040446 Fup 0.43 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2040446 Vd NA 6.436 L/kg 1compartment NA NA Human Human +DTXSID2040446 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2040446 TK.Half.Life NA 3.529 hours 1compartment NA NA Human Human +DTXSID2040446 Css NA 0.01295 mg/L 3compartmentss NA 50% Human Human +DTXSID2040446 Css NA 0.138 mg/L 3compartmentss NA 95% Human Human +DTXSID2040446 Css NA 0.02372 mg/L PBTK NA 50% Human Human +DTXSID2040446 Css NA 0.173 mg/L PBTK NA 95% Human Human +DTXSID2040446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040446 Fup 0.43 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2040446 Vd NA 6.547 L/kg 1compartment NA NA Rat Human +DTXSID2040446 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2040446 TK.Half.Life NA 1.902 hours 1compartment NA NA Rat Human +DTXSID2040446 Css NA 0.001501 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040446 Css NA 0.01376 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040446 Css NA 0.002974 mg/L PBTK NA 50% Rat Human +DTXSID2040446 Css NA 0.0169 mg/L PBTK NA 95% Rat Human +DTXSID2040525 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040525 Fup 0.0747 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040525 Vd NA 1.048 L/kg 1compartment NA NA Human Human +DTXSID2040525 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2040525 TK.Half.Life NA 3.406 hours 1compartment NA NA Human Human +DTXSID2040525 Css NA 0.3899 mg/L 3compartmentss NA 50% Human Human +DTXSID2040525 Css NA 2.971 mg/L 3compartmentss NA 95% Human Human +DTXSID2040525 Css NA 0.2496 mg/L PBTK NA 50% Human Human +DTXSID2040525 Css NA 1.818 mg/L PBTK NA 95% Human Human +DTXSID2040525 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040525 Fup 0.0747 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040525 Vd NA 0.8105 L/kg 1compartment NA NA Rat Human DTXSID2040525 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040525 TK.Half.Life NA 5.613 hours 1compartment NA NA Rat Human -DTXSID2040525 Css NA 1.516 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040525 Css NA 6.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040525 Css NA 0.8878 mg/L PBTK NA 50% Rat Human -DTXSID2040525 Css NA 3.597 mg/L PBTK NA 95% Rat Human -DTXSID2040579 Clint NA 4.099 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040579 Fup NA 0.2039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040579 Vd NA 2.278 L/kg 1compartment NA NA Human Human -DTXSID2040579 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2040579 TK.Half.Life NA 18.52 hours 1compartment NA NA Human Human -DTXSID2040579 Css NA 0.9032 mg/L 3compartmentss NA 50% Human Human -DTXSID2040579 Css NA 4.437 mg/L 3compartmentss NA 95% Human Human -DTXSID2040579 Css NA 0.6566 mg/L PBTK NA 50% Human Human -DTXSID2040579 Css NA 3.053 mg/L PBTK NA 95% Human Human -DTXSID2040579 Clint NA 4.099 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040579 Fup NA 0.2039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040579 Vd NA 1.745 L/kg 1compartment NA NA Rat Human +DTXSID2040525 TK.Half.Life NA 1.474 hours 1compartment NA NA Rat Human +DTXSID2040525 Css NA 0.05111 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040525 Css NA 0.2968 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040525 Css NA 0.0318 mg/L PBTK NA 50% Rat Human +DTXSID2040525 Css NA 0.1772 mg/L PBTK NA 95% Rat Human +DTXSID2040579 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040579 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040579 Vd NA 1.772 L/kg 1compartment NA NA Human Human +DTXSID2040579 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2040579 TK.Half.Life NA 4.435 hours 1compartment NA NA Human Human +DTXSID2040579 Css NA 0.2359 mg/L 3compartmentss NA 50% Human Human +DTXSID2040579 Css NA 1.774 mg/L 3compartmentss NA 95% Human Human +DTXSID2040579 Css NA 0.1622 mg/L PBTK NA 50% Human Human +DTXSID2040579 Css NA 1.142 mg/L PBTK NA 95% Human Human +DTXSID2040579 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040579 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040579 Vd NA 1.359 L/kg 1compartment NA NA Rat Human DTXSID2040579 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040579 TK.Half.Life NA 5.169 hours 1compartment NA NA Rat Human -DTXSID2040579 Css NA 0.4524 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040579 Css NA 1.552 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040579 Css NA 0.3159 mg/L PBTK NA 50% Rat Human -DTXSID2040579 Css NA 1.001 mg/L PBTK NA 95% Rat Human -DTXSID2040608 Clint NA 28.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040608 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040608 Vd NA 2.505 L/kg 1compartment NA NA Human Human +DTXSID2040579 TK.Half.Life NA 1.602 hours 1compartment NA NA Rat Human +DTXSID2040579 Css NA 0.02841 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040579 Css NA 0.1681 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040579 Css NA 0.01924 mg/L PBTK NA 50% Rat Human +DTXSID2040579 Css NA 0.1056 mg/L PBTK NA 95% Rat Human +DTXSID2040608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040608 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040608 Vd NA 0.7277 L/kg 1compartment NA NA Human Human DTXSID2040608 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040608 TK.Half.Life NA 1.53 hours 1compartment NA NA Human Human -DTXSID2040608 Css NA 0.0153 mg/L 3compartmentss NA 50% Human Human -DTXSID2040608 Css NA 0.2119 mg/L 3compartmentss NA 95% Human Human -DTXSID2040608 Css NA 0.01628 mg/L PBTK NA 50% Human Human -DTXSID2040608 Css NA 0.1855 mg/L PBTK NA 95% Human Human -DTXSID2040608 Clint NA 28.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040608 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040608 Vd NA 2.299 L/kg 1compartment NA NA Rat Human +DTXSID2040608 TK.Half.Life NA 1.356 hours 1compartment NA NA Human Human +DTXSID2040608 Css NA 0.1418 mg/L 3compartmentss NA 50% Human Human +DTXSID2040608 Css NA 1.032 mg/L 3compartmentss NA 95% Human Human +DTXSID2040608 Css NA 0.1088 mg/L PBTK NA 50% Human Human +DTXSID2040608 Css NA 0.6935 mg/L PBTK NA 95% Human Human +DTXSID2040608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040608 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040608 Vd NA 0.7363 L/kg 1compartment NA NA Rat Human DTXSID2040608 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040608 TK.Half.Life NA 0.6365 hours 1compartment NA NA Rat Human -DTXSID2040608 Css NA 0.007501 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040608 Css NA 0.08671 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040608 Css NA 0.008141 mg/L PBTK NA 50% Rat Human -DTXSID2040608 Css NA 0.0693 mg/L PBTK NA 95% Rat Human -DTXSID2040652 Clint NA 25.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040652 Fup NA 0.1845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040652 Vd NA 2.185 L/kg 1compartment NA NA Human Human +DTXSID2040608 TK.Half.Life NA 0.7604 hours 1compartment NA NA Rat Human +DTXSID2040608 Css NA 0.01655 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040608 Css NA 0.08908 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040608 Css NA 0.01255 mg/L PBTK NA 50% Rat Human +DTXSID2040608 Css NA 0.05795 mg/L PBTK NA 95% Rat Human +DTXSID2040652 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040652 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040652 Vd NA 2.243 L/kg 1compartment NA NA Human Human DTXSID2040652 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040652 TK.Half.Life NA 4.633 hours 1compartment NA NA Human Human -DTXSID2040652 Css NA 0.1703 mg/L 3compartmentss NA 50% Human Human -DTXSID2040652 Css NA 1.122 mg/L 3compartmentss NA 95% Human Human -DTXSID2040652 Css NA 0.1223 mg/L PBTK NA 50% Human Human -DTXSID2040652 Css NA 0.7623 mg/L PBTK NA 95% Human Human -DTXSID2040652 Clint NA 25.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040652 Fup NA 0.1845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040652 Vd NA 1.673 L/kg 1compartment NA NA Rat Human +DTXSID2040652 TK.Half.Life NA 5.089 hours 1compartment NA NA Human Human +DTXSID2040652 Css NA 0.1802 mg/L 3compartmentss NA 50% Human Human +DTXSID2040652 Css NA 1.145 mg/L 3compartmentss NA 95% Human Human +DTXSID2040652 Css NA 0.1306 mg/L PBTK NA 50% Human Human +DTXSID2040652 Css NA 0.7879 mg/L PBTK NA 95% Human Human +DTXSID2040652 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040652 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040652 Vd NA 1.719 L/kg 1compartment NA NA Rat Human DTXSID2040652 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040652 TK.Half.Life NA 1.48 hours 1compartment NA NA Rat Human -DTXSID2040652 Css NA 0.09398 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040652 Css NA 0.4518 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040652 Css NA 0.06434 mg/L PBTK NA 50% Rat Human -DTXSID2040652 Css NA 0.2995 mg/L PBTK NA 95% Rat Human -DTXSID2040656 Clint NA 0.1994 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040656 Fup NA 0.6667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040656 Vd NA 1.129 L/kg 1compartment NA NA Human Human -DTXSID2040656 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040656 TK.Half.Life NA 8.751 hours 1compartment NA NA Human Human -DTXSID2040656 Css NA 0.7946 mg/L 3compartmentss NA 50% Human Human -DTXSID2040656 Css NA 5.36 mg/L 3compartmentss NA 95% Human Human -DTXSID2040656 Css NA 0.689 mg/L PBTK NA 50% Human Human -DTXSID2040656 Css NA 3.552 mg/L PBTK NA 95% Human Human -DTXSID2040656 Clint NA 0.1994 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040656 Fup NA 0.6667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040656 Vd NA 1.039 L/kg 1compartment NA NA Rat Human +DTXSID2040652 TK.Half.Life NA 1.59 hours 1compartment NA NA Rat Human +DTXSID2040652 Css NA 0.02279 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040652 Css NA 0.1109 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040652 Css NA 0.01656 mg/L PBTK NA 50% Rat Human +DTXSID2040652 Css NA 0.07786 mg/L PBTK NA 95% Rat Human +DTXSID2040656 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040656 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040656 Vd NA 1.087 L/kg 1compartment NA NA Human Human +DTXSID2040656 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2040656 TK.Half.Life NA 11.9 hours 1compartment NA NA Human Human +DTXSID2040656 Css NA 1.128 mg/L 3compartmentss NA 50% Human Human +DTXSID2040656 Css NA 7.818 mg/L 3compartmentss NA 95% Human Human +DTXSID2040656 Css NA 0.9596 mg/L PBTK NA 50% Human Human +DTXSID2040656 Css NA 5.089 mg/L PBTK NA 95% Human Human +DTXSID2040656 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040656 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040656 Vd NA 1.001 L/kg 1compartment NA NA Rat Human DTXSID2040656 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040656 TK.Half.Life NA 3.002 hours 1compartment NA NA Rat Human -DTXSID2040656 Css NA 0.2462 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040656 Css NA 1.652 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040656 Css NA 0.2058 mg/L PBTK NA 50% Rat Human -DTXSID2040656 Css NA 0.9942 mg/L PBTK NA 95% Rat Human -DTXSID2040731 Clint NA 55.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040731 Fup NA 0.0747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040731 Vd NA 1.457 L/kg 1compartment NA NA Human Human +DTXSID2040656 TK.Half.Life NA 3.575 hours 1compartment NA NA Rat Human +DTXSID2040656 Css NA 0.06865 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040656 Css NA 0.454 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040656 Css NA 0.05854 mg/L PBTK NA 50% Rat Human +DTXSID2040656 Css NA 0.2818 mg/L PBTK NA 95% Rat Human +DTXSID2040731 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040731 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040731 Vd NA 1.802 L/kg 1compartment NA NA Human Human DTXSID2040731 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040731 TK.Half.Life NA 2.756 hours 1compartment NA NA Human Human -DTXSID2040731 Css NA 0.1707 mg/L 3compartmentss NA 50% Human Human -DTXSID2040731 Css NA 1.324 mg/L 3compartmentss NA 95% Human Human -DTXSID2040731 Css NA 0.1109 mg/L PBTK NA 50% Human Human -DTXSID2040731 Css NA 0.8215 mg/L PBTK NA 95% Human Human -DTXSID2040731 Clint NA 55.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040731 Fup NA 0.0747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040731 Vd NA 1.107 L/kg 1compartment NA NA Rat Human +DTXSID2040731 TK.Half.Life NA 4.807 hours 1compartment NA NA Human Human +DTXSID2040731 Css NA 0.2661 mg/L 3compartmentss NA 50% Human Human +DTXSID2040731 Css NA 1.982 mg/L 3compartmentss NA 95% Human Human +DTXSID2040731 Css NA 0.1815 mg/L PBTK NA 50% Human Human +DTXSID2040731 Css NA 1.268 mg/L PBTK NA 95% Human Human +DTXSID2040731 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040731 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040731 Vd NA 1.377 L/kg 1compartment NA NA Rat Human DTXSID2040731 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040731 TK.Half.Life NA 1.042 hours 1compartment NA NA Rat Human -DTXSID2040731 Css NA 0.09762 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040731 Css NA 0.5893 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040731 Css NA 0.05955 mg/L PBTK NA 50% Rat Human -DTXSID2040731 Css NA 0.3449 mg/L PBTK NA 95% Rat Human -DTXSID2040733 Clint NA 2.414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040733 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040733 Vd NA 11.66 L/kg 1compartment NA NA Human Human -DTXSID2040733 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID2040733 TK.Half.Life NA 3072 hours 1compartment NA NA Human Human -DTXSID2040733 Css NA 16.34 mg/L 3compartmentss NA 50% Human Human -DTXSID2040733 Css NA 90.52 mg/L 3compartmentss NA 95% Human Human -DTXSID2040733 Css NA 21.95 mg/L PBTK NA 50% Human Human -DTXSID2040733 Css NA 115.2 mg/L PBTK NA 95% Human Human -DTXSID2040733 Clint NA 2.414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040733 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040733 Vd NA 9.239 L/kg 1compartment NA NA Rat Human -DTXSID2040733 Days.Css NA 461 Days PBTK NA NA Rat Human -DTXSID2040733 TK.Half.Life NA 418.1 hours 1compartment NA NA Rat Human -DTXSID2040733 Css NA 8.824 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040733 Css NA 34.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040733 Css NA 11.82 mg/L PBTK NA 50% Rat Human -DTXSID2040733 Css NA 46.62 mg/L PBTK NA 95% Rat Human -DTXSID2040735 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040735 Fup NA 0.522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040735 Vd NA 1.968 L/kg 1compartment NA NA Human Human -DTXSID2040735 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID2040735 TK.Half.Life NA 37.23 hours 1compartment NA NA Human Human -DTXSID2040735 Css NA 1.932 mg/L 3compartmentss NA 50% Human Human -DTXSID2040735 Css NA 9.273 mg/L 3compartmentss NA 95% Human Human -DTXSID2040735 Css NA 1.621 mg/L PBTK NA 50% Human Human -DTXSID2040735 Css NA 6.159 mg/L PBTK NA 95% Human Human -DTXSID2040735 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040735 Fup NA 0.522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040735 Vd NA 1.599 L/kg 1compartment NA NA Rat Human -DTXSID2040735 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2040735 TK.Half.Life NA 7.602 hours 1compartment NA NA Rat Human -DTXSID2040735 Css NA 0.5089 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040735 Css NA 2.128 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040735 Css NA 0.4165 mg/L PBTK NA 50% Rat Human -DTXSID2040735 Css NA 1.334 mg/L PBTK NA 95% Rat Human -DTXSID2040739 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040739 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040739 Vd NA 0.5467 L/kg 1compartment NA NA Human Human +DTXSID2040731 TK.Half.Life NA 1.716 hours 1compartment NA NA Rat Human +DTXSID2040731 Css NA 0.03432 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040731 Css NA 0.1958 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040731 Css NA 0.02298 mg/L PBTK NA 50% Rat Human +DTXSID2040731 Css NA 0.1255 mg/L PBTK NA 95% Rat Human +DTXSID2040735 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040735 Fup 0.367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040735 Vd NA 2.388 L/kg 1compartment NA NA Human Human +DTXSID2040735 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2040735 TK.Half.Life NA 3.859 hours 1compartment NA NA Human Human +DTXSID2040735 Css NA 0.105 mg/L 3compartmentss NA 50% Human Human +DTXSID2040735 Css NA 0.6773 mg/L 3compartmentss NA 95% Human Human +DTXSID2040735 Css NA 0.08078 mg/L PBTK NA 50% Human Human +DTXSID2040735 Css NA 0.4832 mg/L PBTK NA 95% Human Human +DTXSID2040735 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040735 Fup 0.367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040735 Vd NA 1.858 L/kg 1compartment NA NA Rat Human +DTXSID2040735 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2040735 TK.Half.Life NA 1.195 hours 1compartment NA NA Rat Human +DTXSID2040735 Css NA 0.01288 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040735 Css NA 0.06529 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040735 Css NA 0.009999 mg/L PBTK NA 50% Rat Human +DTXSID2040735 Css NA 0.04766 mg/L PBTK NA 95% Rat Human +DTXSID2040739 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040739 Fup 0.633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040739 Vd NA 0.4326 L/kg 1compartment NA NA Human Human DTXSID2040739 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040739 TK.Half.Life NA 3.538 hours 1compartment NA NA Human Human -DTXSID2040739 Css NA 0.911 mg/L 3compartmentss NA 50% Human Human -DTXSID2040739 Css NA 5.668 mg/L 3compartmentss NA 95% Human Human -DTXSID2040739 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID2040739 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID2040739 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040739 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040739 Vd NA 0.5805 L/kg 1compartment NA NA Rat Human +DTXSID2040739 TK.Half.Life NA 4.421 hours 1compartment NA NA Human Human +DTXSID2040739 Css NA 0.7078 mg/L 3compartmentss NA 50% Human Human +DTXSID2040739 Css NA 4.49 mg/L 3compartmentss NA 95% Human Human +DTXSID2040739 Css NA 0.5154 mg/L PBTK NA 50% Human Human +DTXSID2040739 Css NA 2.759 mg/L PBTK NA 95% Human Human +DTXSID2040739 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040739 Fup 0.633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040739 Vd NA 0.4565 L/kg 1compartment NA NA Rat Human DTXSID2040739 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040739 TK.Half.Life NA 1.28 hours 1compartment NA NA Rat Human -DTXSID2040739 Css NA 0.231 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040739 Css NA 1.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040739 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID2040739 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID2040783 Clint NA 69.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040783 Fup NA 0.0517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040783 Vd NA 3.072 L/kg 1compartment NA NA Human Human -DTXSID2040783 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2040783 TK.Half.Life NA 19.18 hours 1compartment NA NA Human Human -DTXSID2040783 Css NA 0.6946 mg/L 3compartmentss NA 50% Human Human -DTXSID2040783 Css NA 4.442 mg/L 3compartmentss NA 95% Human Human -DTXSID2040783 Css NA 0.4811 mg/L PBTK NA 50% Human Human -DTXSID2040783 Css NA 3 mg/L PBTK NA 95% Human Human -DTXSID2040783 Clint NA 69.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040783 Fup NA 0.0517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040783 Vd NA 2.302 L/kg 1compartment NA NA Rat Human -DTXSID2040783 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040783 TK.Half.Life NA 3.144 hours 1compartment NA NA Rat Human -DTXSID2040783 Css NA 0.3876 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040783 Css NA 2.109 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040783 Css NA 0.2567 mg/L PBTK NA 50% Rat Human -DTXSID2040783 Css NA 1.379 mg/L PBTK NA 95% Rat Human -DTXSID2040787 Clint NA 116.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040787 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040787 Vd NA 3.391 L/kg 1compartment NA NA Human Human -DTXSID2040787 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040787 TK.Half.Life NA 4.492 hours 1compartment NA NA Human Human -DTXSID2040787 Css NA 0.06567 mg/L 3compartmentss NA 50% Human Human -DTXSID2040787 Css NA 0.4261 mg/L 3compartmentss NA 95% Human Human -DTXSID2040787 Css NA 0.0488 mg/L PBTK NA 50% Human Human -DTXSID2040787 Css NA 0.3105 mg/L PBTK NA 95% Human Human -DTXSID2040787 Clint NA 116.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040787 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040787 Vd NA 2.637 L/kg 1compartment NA NA Rat Human -DTXSID2040787 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040787 TK.Half.Life NA 1.134 hours 1compartment NA NA Rat Human -DTXSID2040787 Css NA 0.03663 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040787 Css NA 0.1982 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040787 Css NA 0.02618 mg/L PBTK NA 50% Rat Human -DTXSID2040787 Css NA 0.1363 mg/L PBTK NA 95% Rat Human -DTXSID2040945 Clint NA 374.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040945 Fup NA 0.0542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2040945 Vd NA 2.095 L/kg 1compartment NA NA Human Human -DTXSID2040945 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2040945 TK.Half.Life NA 2.325 hours 1compartment NA NA Human Human -DTXSID2040945 Css NA 0.0416 mg/L 3compartmentss NA 50% Human Human -DTXSID2040945 Css NA 0.3097 mg/L 3compartmentss NA 95% Human Human -DTXSID2040945 Css NA 0.02745 mg/L PBTK NA 50% Human Human -DTXSID2040945 Css NA 0.2014 mg/L PBTK NA 95% Human Human -DTXSID2040945 Clint NA 374.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040945 Fup NA 0.0542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2040945 Vd NA 1.572 L/kg 1compartment NA NA Rat Human -DTXSID2040945 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2040945 TK.Half.Life NA 0.7567 hours 1compartment NA NA Rat Human -DTXSID2040945 Css NA 0.02344 mg/L 3compartmentss NA 50% Rat Human -DTXSID2040945 Css NA 0.1428 mg/L 3compartmentss NA 95% Rat Human -DTXSID2040945 Css NA 0.01467 mg/L PBTK NA 50% Rat Human -DTXSID2040945 Css NA 0.08589 mg/L PBTK NA 95% Rat Human -DTXSID2041046 Clint NA 3.051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2040739 TK.Half.Life NA 1.59 hours 1compartment NA NA Rat Human +DTXSID2040739 Css NA 0.00377 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040739 Css NA 0.02452 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040739 Css NA 0.002612 mg/L PBTK NA 50% Rat Human +DTXSID2040739 Css NA 0.01444 mg/L PBTK NA 95% Rat Human +DTXSID2040783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040783 Fup 0.0235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040783 Vd NA 2.82 L/kg 1compartment NA NA Human Human +DTXSID2040783 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID2040783 TK.Half.Life NA 41.36 hours 1compartment NA NA Human Human +DTXSID2040783 Css NA 1.892 mg/L 3compartmentss NA 50% Human Human +DTXSID2040783 Css NA 13.53 mg/L 3compartmentss NA 95% Human Human +DTXSID2040783 Css NA 1.276 mg/L PBTK NA 50% Human Human +DTXSID2040783 Css NA 8.741 mg/L PBTK NA 95% Human Human +DTXSID2040783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040783 Fup 0.0235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040783 Vd NA 2.109 L/kg 1compartment NA NA Rat Human +DTXSID2040783 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID2040783 TK.Half.Life NA 8.006 hours 1compartment NA NA Rat Human +DTXSID2040783 Css NA 0.2447 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040783 Css NA 1.429 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040783 Css NA 0.1633 mg/L PBTK NA 50% Rat Human +DTXSID2040783 Css NA 0.9297 mg/L PBTK NA 95% Rat Human +DTXSID2040789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040789 Fup 0.0268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040789 Vd NA 2.927 L/kg 1compartment NA NA Human Human +DTXSID2040789 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID2040789 TK.Half.Life NA 46.74 hours 1compartment NA NA Human Human +DTXSID2040789 Css NA 1.998 mg/L 3compartmentss NA 50% Human Human +DTXSID2040789 Css NA 14.02 mg/L 3compartmentss NA 95% Human Human +DTXSID2040789 Css NA 1.372 mg/L PBTK NA 50% Human Human +DTXSID2040789 Css NA 9.273 mg/L PBTK NA 95% Human Human +DTXSID2040789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040789 Fup 0.0268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040789 Vd NA 2.191 L/kg 1compartment NA NA Rat Human +DTXSID2040789 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID2040789 TK.Half.Life NA 8.135 hours 1compartment NA NA Rat Human +DTXSID2040789 Css NA 0.2602 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040789 Css NA 1.508 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040789 Css NA 0.176 mg/L PBTK NA 50% Rat Human +DTXSID2040789 Css NA 0.9805 mg/L PBTK NA 95% Rat Human +DTXSID2040945 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040945 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040945 Vd NA 3.097 L/kg 1compartment NA NA Human Human +DTXSID2040945 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID2040945 TK.Half.Life NA 49.33 hours 1compartment NA NA Human Human +DTXSID2040945 Css NA 1.592 mg/L 3compartmentss NA 50% Human Human +DTXSID2040945 Css NA 10.83 mg/L 3compartmentss NA 95% Human Human +DTXSID2040945 Css NA 1.11 mg/L PBTK NA 50% Human Human +DTXSID2040945 Css NA 7.235 mg/L PBTK NA 95% Human Human +DTXSID2040945 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040945 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040945 Vd NA 2.324 L/kg 1compartment NA NA Rat Human +DTXSID2040945 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID2040945 TK.Half.Life NA 7.112 hours 1compartment NA NA Rat Human +DTXSID2040945 Css NA 0.0602 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040945 Css NA 0.4363 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040945 Css NA 0.04062 mg/L PBTK NA 50% Rat Human +DTXSID2040945 Css NA 0.2862 mg/L PBTK NA 95% Rat Human +DTXSID2040949 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040949 Fup 0.0343 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2040949 Vd NA 0.3461 L/kg 1compartment NA NA Human Human +DTXSID2040949 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2040949 TK.Half.Life NA 5.981 hours 1compartment NA NA Human Human +DTXSID2040949 Css NA 2.818 mg/L 3compartmentss NA 50% Human Human +DTXSID2040949 Css NA 19.06 mg/L 3compartmentss NA 95% Human Human +DTXSID2040949 Css NA 1.728 mg/L PBTK NA 50% Human Human +DTXSID2040949 Css NA 11.43 mg/L PBTK NA 95% Human Human +DTXSID2040949 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040949 Fup 0.0343 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2040949 Vd NA 0.3352 L/kg 1compartment NA NA Rat Human +DTXSID2040949 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2040949 TK.Half.Life NA 3.65 hours 1compartment NA NA Rat Human +DTXSID2040949 Css NA 0.1875 mg/L 3compartmentss NA 50% Rat Human +DTXSID2040949 Css NA 1.175 mg/L 3compartmentss NA 95% Rat Human +DTXSID2040949 Css NA 0.1116 mg/L PBTK NA 50% Rat Human +DTXSID2040949 Css NA 0.6696 mg/L PBTK NA 95% Rat Human +DTXSID2041046 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2041046 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2041046 Vd NA 0.9156 L/kg 1compartment NA NA Human Human +DTXSID2041046 Vd NA 0.8805 L/kg 1compartment NA NA Human Human DTXSID2041046 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041046 TK.Half.Life NA 2.829 hours 1compartment NA NA Human Human -DTXSID2041046 Css NA 0.2536 mg/L 3compartmentss NA 50% Human Human -DTXSID2041046 Css NA 1.572 mg/L 3compartmentss NA 95% Human Human -DTXSID2041046 Css NA 0.2325 mg/L PBTK NA 50% Human Human -DTXSID2041046 Css NA 1.151 mg/L PBTK NA 95% Human Human -DTXSID2041046 Clint NA 3.051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2041046 TK.Half.Life NA 0.8824 hours 1compartment NA NA Human Human +DTXSID2041046 Css NA 0.04049 mg/L 3compartmentss NA 50% Human Human +DTXSID2041046 Css NA 0.3579 mg/L 3compartmentss NA 95% Human Human +DTXSID2041046 Css NA 0.03624 mg/L PBTK NA 50% Human Human +DTXSID2041046 Css NA 0.2723 mg/L PBTK NA 95% Human Human +DTXSID2041046 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2041046 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2041046 Vd NA 0.9038 L/kg 1compartment NA NA Rat Human +DTXSID2041046 Vd NA 0.8699 L/kg 1compartment NA NA Rat Human DTXSID2041046 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041046 TK.Half.Life NA 1.559 hours 1compartment NA NA Rat Human -DTXSID2041046 Css NA 0.1183 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041046 Css NA 0.5954 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041046 Css NA 0.1062 mg/L PBTK NA 50% Rat Human -DTXSID2041046 Css NA 0.4003 mg/L PBTK NA 95% Rat Human -DTXSID2041125 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041125 Fup NA 0.5248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041125 Vd NA 1.098 L/kg 1compartment NA NA Human Human -DTXSID2041125 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2041125 TK.Half.Life NA 14.53 hours 1compartment NA NA Human Human -DTXSID2041125 Css NA 1.392 mg/L 3compartmentss NA 50% Human Human -DTXSID2041125 Css NA 7.85 mg/L 3compartmentss NA 95% Human Human -DTXSID2041125 Css NA 1.149 mg/L PBTK NA 50% Human Human -DTXSID2041125 Css NA 5.124 mg/L PBTK NA 95% Human Human -DTXSID2041125 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041125 Fup NA 0.5248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041125 Vd NA 0.9889 L/kg 1compartment NA NA Rat Human -DTXSID2041125 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041125 TK.Half.Life NA 4.227 hours 1compartment NA NA Rat Human -DTXSID2041125 Css NA 0.3686 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041125 Css NA 1.897 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041125 Css NA 0.2946 mg/L PBTK NA 50% Rat Human -DTXSID2041125 Css NA 1.15 mg/L PBTK NA 95% Rat Human +DTXSID2041046 TK.Half.Life NA 0.4609 hours 1compartment NA NA Rat Human +DTXSID2041046 Css NA 0.004995 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041046 Css NA 0.03326 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041046 Css NA 0.004575 mg/L PBTK NA 50% Rat Human +DTXSID2041046 Css NA 0.02456 mg/L PBTK NA 95% Rat Human DTXSID2041200 Clint 59.17 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID2041200 Fup NA 0.0581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041200 Vd NA 1.613 L/kg 1compartment NA NA Human Human +DTXSID2041200 Fup 0.0379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041200 Vd NA 2.093 L/kg 1compartment NA NA Human Human DTXSID2041200 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041200 TK.Half.Life NA 3.461 hours 1compartment NA NA Human Human -DTXSID2041200 Css NA 0.2088 mg/L 3compartmentss NA 50% Human Human -DTXSID2041200 Css NA 1.686 mg/L 3compartmentss NA 95% Human Human -DTXSID2041200 Css NA 0.1356 mg/L PBTK NA 50% Human Human -DTXSID2041200 Css NA 1.054 mg/L PBTK NA 95% Human Human +DTXSID2041200 TK.Half.Life NA 6.448 hours 1compartment NA NA Human Human +DTXSID2041200 Css NA 0.3528 mg/L 3compartmentss NA 50% Human Human +DTXSID2041200 Css NA 2.816 mg/L 3compartmentss NA 95% Human Human +DTXSID2041200 Css NA 0.2294 mg/L PBTK NA 50% Human Human +DTXSID2041200 Css NA 1.763 mg/L PBTK NA 95% Human Human DTXSID2041200 Clint 59.17 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID2041200 Fup NA 0.0581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041200 Vd NA 1.217 L/kg 1compartment NA NA Rat Human +DTXSID2041200 Fup 0.0379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041200 Vd NA 1.563 L/kg 1compartment NA NA Rat Human DTXSID2041200 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041200 TK.Half.Life NA 1.269 hours 1compartment NA NA Rat Human -DTXSID2041200 Css NA 0.1211 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041200 Css NA 0.7211 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041200 Css NA 0.07395 mg/L PBTK NA 50% Rat Human -DTXSID2041200 Css NA 0.4237 mg/L PBTK NA 95% Rat Human -DTXSID2041208 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041208 Fup NA 0.2101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041208 Vd NA 0.7118 L/kg 1compartment NA NA Human Human -DTXSID2041208 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2041208 TK.Half.Life NA 22.72 hours 1compartment NA NA Human Human -DTXSID2041208 Css NA 3.745 mg/L 3compartmentss NA 50% Human Human -DTXSID2041208 Css NA 13.96 mg/L 3compartmentss NA 95% Human Human -DTXSID2041208 Css NA 2.593 mg/L PBTK NA 50% Human Human -DTXSID2041208 Css NA 8.663 mg/L PBTK NA 95% Human Human -DTXSID2041208 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041208 Fup NA 0.2101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041208 Vd NA 0.6311 L/kg 1compartment NA NA Rat Human +DTXSID2041200 TK.Half.Life NA 2.04 hours 1compartment NA NA Rat Human +DTXSID2041200 Css NA 0.0457 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041200 Css NA 0.3025 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041200 Css NA 0.0292 mg/L PBTK NA 50% Rat Human +DTXSID2041200 Css NA 0.1853 mg/L PBTK NA 95% Rat Human +DTXSID2041208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041208 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041208 Vd NA 1.975 L/kg 1compartment NA NA Human Human +DTXSID2041208 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2041208 TK.Half.Life NA 3.52 hours 1compartment NA NA Human Human +DTXSID2041208 Css NA 0.1033 mg/L 3compartmentss NA 50% Human Human +DTXSID2041208 Css NA 0.7873 mg/L 3compartmentss NA 95% Human Human +DTXSID2041208 Css NA 0.07722 mg/L PBTK NA 50% Human Human +DTXSID2041208 Css NA 0.5319 mg/L PBTK NA 95% Human Human +DTXSID2041208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041208 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041208 Vd NA 1.542 L/kg 1compartment NA NA Rat Human DTXSID2041208 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041208 TK.Half.Life NA 6.678 hours 1compartment NA NA Rat Human -DTXSID2041208 Css NA 1.044 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041208 Css NA 3.176 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041208 Css NA 0.6856 mg/L PBTK NA 50% Rat Human -DTXSID2041208 Css NA 1.853 mg/L PBTK NA 95% Rat Human +DTXSID2041208 TK.Half.Life NA 1.233 hours 1compartment NA NA Rat Human +DTXSID2041208 Css NA 0.005162 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041208 Css NA 0.03782 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041208 Css NA 0.003806 mg/L PBTK NA 50% Rat Human +DTXSID2041208 Css NA 0.02584 mg/L PBTK NA 95% Rat Human DTXSID2041250 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2041250 Fup 0.00728 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2041250 Vd NA 0.8428 L/kg 1compartment NA NA Human Human -DTXSID2041250 Days.Css NA 218 Days PBTK NA NA Human Human +DTXSID2041250 Days.Css NA 219 Days PBTK NA NA Human Human DTXSID2041250 TK.Half.Life NA 835.2 hours 1compartment NA NA Human Human -DTXSID2041250 Css NA 125.2 mg/L 3compartmentss NA 50% Human Human -DTXSID2041250 Css NA 504.1 mg/L 3compartmentss NA 95% Human Human -DTXSID2041250 Css NA 75.66 mg/L PBTK NA 50% Human Human -DTXSID2041250 Css NA 295.9 mg/L PBTK NA 95% Human Human +DTXSID2041250 Css NA 120.2 mg/L 3compartmentss NA 50% Human Human +DTXSID2041250 Css NA 483.6 mg/L 3compartmentss NA 95% Human Human +DTXSID2041250 Css NA 73.13 mg/L PBTK NA 50% Human Human +DTXSID2041250 Css NA 280 mg/L PBTK NA 95% Human Human DTXSID2041250 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2041250 Fup 0.00728 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2041250 Vd NA 0.6389 L/kg 1compartment NA NA Rat Human -DTXSID2041250 Days.Css NA 51 Days PBTK NA NA Rat Human +DTXSID2041250 Days.Css NA 52 Days PBTK NA NA Rat Human DTXSID2041250 TK.Half.Life NA 198.8 hours 1compartment NA NA Rat Human -DTXSID2041250 Css NA 35.24 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041250 Css NA 116.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041250 Css NA 19.96 mg/L PBTK NA 50% Rat Human -DTXSID2041250 Css NA 64.03 mg/L PBTK NA 95% Rat Human -DTXSID2041252 Clint NA 1.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041252 Fup NA 0.1164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041252 Vd NA 2.004 L/kg 1compartment NA NA Human Human -DTXSID2041252 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID2041252 TK.Half.Life NA 66.52 hours 1compartment NA NA Human Human -DTXSID2041252 Css NA 4.499 mg/L 3compartmentss NA 50% Human Human -DTXSID2041252 Css NA 19.65 mg/L 3compartmentss NA 95% Human Human -DTXSID2041252 Css NA 3.087 mg/L PBTK NA 50% Human Human -DTXSID2041252 Css NA 12.3 mg/L PBTK NA 95% Human Human -DTXSID2041252 Clint NA 1.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041252 Fup NA 0.1164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041252 Vd NA 1.523 L/kg 1compartment NA NA Rat Human -DTXSID2041252 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2041252 TK.Half.Life NA 17.19 hours 1compartment NA NA Rat Human -DTXSID2041252 Css NA 1.923 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041252 Css NA 6.414 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041252 Css NA 1.25 mg/L PBTK NA 50% Rat Human -DTXSID2041252 Css NA 3.737 mg/L PBTK NA 95% Rat Human +DTXSID2041250 Css NA 7.944 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041250 Css NA 26.51 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041250 Css NA 4.656 mg/L PBTK NA 50% Rat Human +DTXSID2041250 Css NA 15.05 mg/L PBTK NA 95% Rat Human +DTXSID2041252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041252 Fup 0.0673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041252 Vd NA 1.623 L/kg 1compartment NA NA Human Human +DTXSID2041252 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2041252 TK.Half.Life NA 6.313 hours 1compartment NA NA Human Human +DTXSID2041252 Css NA 0.4623 mg/L 3compartmentss NA 50% Human Human +DTXSID2041252 Css NA 3.153 mg/L 3compartmentss NA 95% Human Human +DTXSID2041252 Css NA 0.3027 mg/L PBTK NA 50% Human Human +DTXSID2041252 Css NA 2.014 mg/L PBTK NA 95% Human Human +DTXSID2041252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041252 Fup 0.0673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041252 Vd NA 1.226 L/kg 1compartment NA NA Rat Human +DTXSID2041252 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2041252 TK.Half.Life NA 2.357 hours 1compartment NA NA Rat Human +DTXSID2041252 Css NA 0.06004 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041252 Css NA 0.3193 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041252 Css NA 0.03833 mg/L PBTK NA 50% Rat Human +DTXSID2041252 Css NA 0.1969 mg/L PBTK NA 95% Rat Human DTXSID2041256 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2041256 Fup NA 0.9854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041256 Vd NA 0.8766 L/kg 1compartment NA NA Human Human +DTXSID2041256 Vd NA 0.8436 L/kg 1compartment NA NA Human Human DTXSID2041256 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041256 TK.Half.Life NA 5.776 hours 1compartment NA NA Human Human -DTXSID2041256 Css NA 0.834 mg/L 3compartmentss NA 50% Human Human -DTXSID2041256 Css NA 3.367 mg/L 3compartmentss NA 95% Human Human -DTXSID2041256 Css NA 0.7157 mg/L PBTK NA 50% Human Human -DTXSID2041256 Css NA 2.329 mg/L PBTK NA 95% Human Human +DTXSID2041256 TK.Half.Life NA 5.554 hours 1compartment NA NA Human Human +DTXSID2041256 Css NA 0.7134 mg/L 3compartmentss NA 50% Human Human +DTXSID2041256 Css NA 2.894 mg/L 3compartmentss NA 95% Human Human +DTXSID2041256 Css NA 0.6083 mg/L PBTK NA 50% Human Human +DTXSID2041256 Css NA 2.018 mg/L PBTK NA 95% Human Human DTXSID2041256 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2041256 Fup NA 0.9854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041256 Vd NA 0.8989 L/kg 1compartment NA NA Rat Human +DTXSID2041256 Vd NA 0.871 L/kg 1compartment NA NA Rat Human DTXSID2041256 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041256 TK.Half.Life NA 2.013 hours 1compartment NA NA Rat Human -DTXSID2041256 Css NA 0.212 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041256 Css NA 0.7877 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041256 Css NA 0.1785 mg/L PBTK NA 50% Rat Human -DTXSID2041256 Css NA 0.5089 mg/L PBTK NA 95% Rat Human -DTXSID2041389 Clint NA 8.693 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041389 Fup NA 0.1194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041389 Vd NA 2.091 L/kg 1compartment NA NA Human Human +DTXSID2041256 TK.Half.Life NA 1.95 hours 1compartment NA NA Rat Human +DTXSID2041256 Css NA 0.01285 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041256 Css NA 0.07183 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041256 Css NA 0.01062 mg/L PBTK NA 50% Rat Human +DTXSID2041256 Css NA 0.05232 mg/L PBTK NA 95% Rat Human +DTXSID2041389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041389 Fup 0.0426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041389 Vd NA 0.955 L/kg 1compartment NA NA Human Human DTXSID2041389 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041389 TK.Half.Life NA 12.96 hours 1compartment NA NA Human Human -DTXSID2041389 Css NA 0.7902 mg/L 3compartmentss NA 50% Human Human -DTXSID2041389 Css NA 4.94 mg/L 3compartmentss NA 95% Human Human -DTXSID2041389 Css NA 0.5432 mg/L PBTK NA 50% Human Human -DTXSID2041389 Css NA 3.229 mg/L PBTK NA 95% Human Human -DTXSID2041389 Clint NA 8.693 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041389 Fup NA 0.1194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041389 Vd NA 1.588 L/kg 1compartment NA NA Rat Human +DTXSID2041389 TK.Half.Life NA 4.671 hours 1compartment NA NA Human Human +DTXSID2041389 Css NA 0.7157 mg/L 3compartmentss NA 50% Human Human +DTXSID2041389 Css NA 6.698 mg/L 3compartmentss NA 95% Human Human +DTXSID2041389 Css NA 0.4436 mg/L PBTK NA 50% Human Human +DTXSID2041389 Css NA 4.027 mg/L PBTK NA 95% Human Human +DTXSID2041389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041389 Fup 0.0426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041389 Vd NA 0.727 L/kg 1compartment NA NA Rat Human DTXSID2041389 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041389 TK.Half.Life NA 4.065 hours 1compartment NA NA Rat Human -DTXSID2041389 Css NA 0.421 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041389 Css NA 1.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041389 Css NA 0.2747 mg/L PBTK NA 50% Rat Human -DTXSID2041389 Css NA 1.19 mg/L PBTK NA 95% Rat Human -DTXSID2041412 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041412 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041412 Vd NA 0.7831 L/kg 1compartment NA NA Human Human +DTXSID2041389 TK.Half.Life NA 2.071 hours 1compartment NA NA Rat Human +DTXSID2041389 Css NA 0.0941 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041389 Css NA 0.6355 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041389 Css NA 0.05658 mg/L PBTK NA 50% Rat Human +DTXSID2041389 Css NA 0.3678 mg/L PBTK NA 95% Rat Human +DTXSID2041412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041412 Fup 0.837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041412 Vd NA 0.7538 L/kg 1compartment NA NA Human Human DTXSID2041412 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041412 TK.Half.Life NA 5.067 hours 1compartment NA NA Human Human -DTXSID2041412 Css NA 0.826 mg/L 3compartmentss NA 50% Human Human -DTXSID2041412 Css NA 5.558 mg/L 3compartmentss NA 95% Human Human -DTXSID2041412 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID2041412 Css NA 3.572 mg/L PBTK NA 95% Human Human -DTXSID2041412 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041412 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041412 Vd NA 0.8204 L/kg 1compartment NA NA Rat Human +DTXSID2041412 TK.Half.Life NA 5.835 hours 1compartment NA NA Human Human +DTXSID2041412 Css NA 0.8204 mg/L 3compartmentss NA 50% Human Human +DTXSID2041412 Css NA 5.096 mg/L 3compartmentss NA 95% Human Human +DTXSID2041412 Css NA 0.6818 mg/L PBTK NA 50% Human Human +DTXSID2041412 Css NA 3.279 mg/L PBTK NA 95% Human Human +DTXSID2041412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041412 Fup 0.837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041412 Vd NA 0.7792 L/kg 1compartment NA NA Rat Human DTXSID2041412 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041412 TK.Half.Life NA 1.809 hours 1compartment NA NA Rat Human -DTXSID2041412 Css NA 0.2077 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041412 Css NA 1.328 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041412 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID2041412 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID2041416 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041416 Fup NA 0.7003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041416 Vd NA 1.639 L/kg 1compartment NA NA Human Human -DTXSID2041416 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2041416 TK.Half.Life NA 18.6 hours 1compartment NA NA Human Human -DTXSID2041416 Css NA 1.133 mg/L 3compartmentss NA 50% Human Human -DTXSID2041416 Css NA 7.176 mg/L 3compartmentss NA 95% Human Human -DTXSID2041416 Css NA 1.026 mg/L PBTK NA 50% Human Human -DTXSID2041416 Css NA 4.761 mg/L PBTK NA 95% Human Human -DTXSID2041416 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041416 Fup NA 0.7003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041416 Vd NA 1.413 L/kg 1compartment NA NA Rat Human -DTXSID2041416 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041416 TK.Half.Life NA 4.69 hours 1compartment NA NA Rat Human -DTXSID2041416 Css NA 0.2942 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041416 Css NA 1.829 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041416 Css NA 0.2593 mg/L PBTK NA 50% Rat Human -DTXSID2041416 Css NA 1.131 mg/L PBTK NA 95% Rat Human -DTXSID2041418 Clint NA 0.005366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041418 Fup NA 0.3794 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041418 Vd NA 0.4633 L/kg 1compartment NA NA Human Human +DTXSID2041412 TK.Half.Life NA 2.054 hours 1compartment NA NA Rat Human +DTXSID2041412 Css NA 0.01518 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041412 Css NA 0.1158 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041412 Css NA 0.01213 mg/L PBTK NA 50% Rat Human +DTXSID2041412 Css NA 0.0757 mg/L PBTK NA 95% Rat Human +DTXSID2041418 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041418 Fup 0.576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041418 Vd NA 0.5808 L/kg 1compartment NA NA Human Human DTXSID2041418 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041418 TK.Half.Life NA 7.837 hours 1compartment NA NA Human Human -DTXSID2041418 Css NA 1.906 mg/L 3compartmentss NA 50% Human Human -DTXSID2041418 Css NA 8.138 mg/L 3compartmentss NA 95% Human Human -DTXSID2041418 Css NA 1.378 mg/L PBTK NA 50% Human Human -DTXSID2041418 Css NA 5.181 mg/L PBTK NA 95% Human Human -DTXSID2041418 Clint NA 0.005366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041418 Fup NA 0.3794 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041418 Vd NA 0.4621 L/kg 1compartment NA NA Rat Human +DTXSID2041418 TK.Half.Life NA 6.533 hours 1compartment NA NA Human Human +DTXSID2041418 Css NA 1.09 mg/L 3compartmentss NA 50% Human Human +DTXSID2041418 Css NA 7.596 mg/L 3compartmentss NA 95% Human Human +DTXSID2041418 Css NA 0.8629 mg/L PBTK NA 50% Human Human +DTXSID2041418 Css NA 4.739 mg/L PBTK NA 95% Human Human +DTXSID2041418 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041418 Fup 0.576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041418 Vd NA 0.5815 L/kg 1compartment NA NA Rat Human DTXSID2041418 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041418 TK.Half.Life NA 2.673 hours 1compartment NA NA Rat Human -DTXSID2041418 Css NA 0.5266 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041418 Css NA 1.956 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041418 Css NA 0.3642 mg/L PBTK NA 50% Rat Human -DTXSID2041418 Css NA 1.15 mg/L PBTK NA 95% Rat Human -DTXSID2041460 Clint NA 1.082 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041460 Fup NA 0.0684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041460 Vd NA 0.3898 L/kg 1compartment NA NA Human Human -DTXSID2041460 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2041460 TK.Half.Life NA 13.35 hours 1compartment NA NA Human Human -DTXSID2041460 Css NA 5.588 mg/L 3compartmentss NA 50% Human Human -DTXSID2041460 Css NA 29.24 mg/L 3compartmentss NA 95% Human Human -DTXSID2041460 Css NA 3.544 mg/L PBTK NA 50% Human Human -DTXSID2041460 Css NA 17.47 mg/L PBTK NA 95% Human Human -DTXSID2041460 Clint NA 1.082 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041460 Fup NA 0.0684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041460 Vd NA 0.3817 L/kg 1compartment NA NA Rat Human -DTXSID2041460 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041460 TK.Half.Life NA 6.614 hours 1compartment NA NA Rat Human -DTXSID2041460 Css NA 2.331 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041460 Css NA 9.804 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041460 Css NA 1.386 mg/L PBTK NA 50% Rat Human -DTXSID2041460 Css NA 5.44 mg/L PBTK NA 95% Rat Human +DTXSID2041418 TK.Half.Life NA 2.227 hours 1compartment NA NA Rat Human +DTXSID2041418 Css NA 0.02102 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041418 Css NA 0.1802 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041418 Css NA 0.01609 mg/L PBTK NA 50% Rat Human +DTXSID2041418 Css NA 0.1121 mg/L PBTK NA 95% Rat Human +DTXSID2041460 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041460 Fup 0.0653 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041460 Vd NA 0.3813 L/kg 1compartment NA NA Human Human +DTXSID2041460 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID2041460 TK.Half.Life NA 37.79 hours 1compartment NA NA Human Human +DTXSID2041460 Css NA 14.77 mg/L 3compartmentss NA 50% Human Human +DTXSID2041460 Css NA 62.92 mg/L 3compartmentss NA 95% Human Human +DTXSID2041460 Css NA 9.396 mg/L PBTK NA 50% Human Human +DTXSID2041460 Css NA 37.35 mg/L PBTK NA 95% Human Human +DTXSID2041460 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041460 Fup 0.0653 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041460 Vd NA 0.3733 L/kg 1compartment NA NA Rat Human +DTXSID2041460 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2041460 TK.Half.Life NA 12.6 hours 1compartment NA NA Rat Human +DTXSID2041460 Css NA 0.9687 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041460 Css NA 3.445 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041460 Css NA 0.595 mg/L PBTK NA 50% Rat Human +DTXSID2041460 Css NA 1.984 mg/L PBTK NA 95% Rat Human DTXSID2041464 Clint NA 2.172 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2041464 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2041464 Vd NA 0.8155 L/kg 1compartment NA NA Human Human DTXSID2041464 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2041464 TK.Half.Life NA 1.426 hours 1compartment NA NA Human Human -DTXSID2041464 Css NA 0.1857 mg/L 3compartmentss NA 50% Human Human -DTXSID2041464 Css NA 1.402 mg/L 3compartmentss NA 95% Human Human -DTXSID2041464 Css NA 0.1551 mg/L PBTK NA 50% Human Human -DTXSID2041464 Css NA 0.9793 mg/L PBTK NA 95% Human Human +DTXSID2041464 Css NA 0.1757 mg/L 3compartmentss NA 50% Human Human +DTXSID2041464 Css NA 1.367 mg/L 3compartmentss NA 95% Human Human +DTXSID2041464 Css NA 0.1475 mg/L PBTK NA 50% Human Human +DTXSID2041464 Css NA 0.9607 mg/L PBTK NA 95% Human Human DTXSID2041464 Clint NA 2.172 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2041464 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2041464 Vd NA 0.8548 L/kg 1compartment NA NA Rat Human DTXSID2041464 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2041464 TK.Half.Life NA 0.7698 hours 1compartment NA NA Rat Human -DTXSID2041464 Css NA 0.07785 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041464 Css NA 0.5034 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041464 Css NA 0.06484 mg/L PBTK NA 50% Rat Human -DTXSID2041464 Css NA 0.3122 mg/L PBTK NA 95% Rat Human -DTXSID2041468 Clint NA 0.2337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041468 Fup NA 0.1469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041468 Vd NA 1.676 L/kg 1compartment NA NA Human Human -DTXSID2041468 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID2041468 TK.Half.Life NA 75.24 hours 1compartment NA NA Human Human -DTXSID2041468 Css NA 5.8 mg/L 3compartmentss NA 50% Human Human -DTXSID2041468 Css NA 22.52 mg/L 3compartmentss NA 95% Human Human -DTXSID2041468 Css NA 4.02 mg/L PBTK NA 50% Human Human -DTXSID2041468 Css NA 14.02 mg/L PBTK NA 95% Human Human -DTXSID2041468 Clint NA 0.2337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041468 Fup NA 0.1469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041468 Vd NA 1.293 L/kg 1compartment NA NA Rat Human -DTXSID2041468 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2041468 TK.Half.Life NA 17.75 hours 1compartment NA NA Rat Human -DTXSID2041468 Css NA 1.924 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041468 Css NA 6.66 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041468 Css NA 1.259 mg/L PBTK NA 50% Rat Human -DTXSID2041468 Css NA 3.856 mg/L PBTK NA 95% Rat Human -DTXSID2041545 Clint NA 0.9564 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041545 Fup NA 0.1383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041545 Vd NA 0.5058 L/kg 1compartment NA NA Human Human +DTXSID2041464 Css NA 0.0173 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041464 Css NA 0.1112 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041464 Css NA 0.01485 mg/L PBTK NA 50% Rat Human +DTXSID2041464 Css NA 0.07164 mg/L PBTK NA 95% Rat Human +DTXSID2041468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041468 Fup 0.0988 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041468 Vd NA 1.402 L/kg 1compartment NA NA Human Human +DTXSID2041468 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2041468 TK.Half.Life NA 3.945 hours 1compartment NA NA Human Human +DTXSID2041468 Css NA 0.306 mg/L 3compartmentss NA 50% Human Human +DTXSID2041468 Css NA 2.364 mg/L 3compartmentss NA 95% Human Human +DTXSID2041468 Css NA 0.2014 mg/L PBTK NA 50% Human Human +DTXSID2041468 Css NA 1.495 mg/L PBTK NA 95% Human Human +DTXSID2041468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041468 Fup 0.0988 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041468 Vd NA 1.077 L/kg 1compartment NA NA Rat Human +DTXSID2041468 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2041468 TK.Half.Life NA 1.567 hours 1compartment NA NA Rat Human +DTXSID2041468 Css NA 0.03922 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041468 Css NA 0.2336 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041468 Css NA 0.0253 mg/L PBTK NA 50% Rat Human +DTXSID2041468 Css NA 0.1434 mg/L PBTK NA 95% Rat Human +DTXSID2041545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041545 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041545 Vd NA 0.6113 L/kg 1compartment NA NA Human Human DTXSID2041545 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041545 TK.Half.Life NA 9.347 hours 1compartment NA NA Human Human -DTXSID2041545 Css NA 2.648 mg/L 3compartmentss NA 50% Human Human -DTXSID2041545 Css NA 13.77 mg/L 3compartmentss NA 95% Human Human -DTXSID2041545 Css NA 1.705 mg/L PBTK NA 50% Human Human -DTXSID2041545 Css NA 8.209 mg/L PBTK NA 95% Human Human -DTXSID2041545 Clint NA 0.9564 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041545 Fup NA 0.1383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041545 Vd NA 0.4489 L/kg 1compartment NA NA Rat Human +DTXSID2041545 TK.Half.Life NA 1.159 hours 1compartment NA NA Human Human +DTXSID2041545 Css NA 0.1521 mg/L 3compartmentss NA 50% Human Human +DTXSID2041545 Css NA 1.178 mg/L 3compartmentss NA 95% Human Human +DTXSID2041545 Css NA 0.09944 mg/L PBTK NA 50% Human Human +DTXSID2041545 Css NA 0.7246 mg/L PBTK NA 95% Human Human +DTXSID2041545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041545 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041545 Vd NA 0.5301 L/kg 1compartment NA NA Rat Human DTXSID2041545 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041545 TK.Half.Life NA 4.049 hours 1compartment NA NA Rat Human -DTXSID2041545 Css NA 1.109 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041545 Css NA 4.686 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041545 Css NA 0.6686 mg/L PBTK NA 50% Rat Human -DTXSID2041545 Css NA 2.621 mg/L PBTK NA 95% Rat Human -DTXSID2041547 Clint NA 22.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041547 Fup NA 0.062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041547 Vd NA 2.718 L/kg 1compartment NA NA Human Human -DTXSID2041547 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2041547 TK.Half.Life NA 20.37 hours 1compartment NA NA Human Human -DTXSID2041547 Css NA 0.9366 mg/L 3compartmentss NA 50% Human Human -DTXSID2041547 Css NA 6.184 mg/L 3compartmentss NA 95% Human Human -DTXSID2041547 Css NA 0.6377 mg/L PBTK NA 50% Human Human -DTXSID2041547 Css NA 4.018 mg/L PBTK NA 95% Human Human -DTXSID2041547 Clint NA 22.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041547 Fup NA 0.062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041547 Vd NA 2.04 L/kg 1compartment NA NA Rat Human +DTXSID2041545 TK.Half.Life NA 0.5622 hours 1compartment NA NA Rat Human +DTXSID2041545 Css NA 0.01938 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041545 Css NA 0.1149 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041545 Css NA 0.01246 mg/L PBTK NA 50% Rat Human +DTXSID2041545 Css NA 0.06942 mg/L PBTK NA 95% Rat Human +DTXSID2041547 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041547 Fup 0.0373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041547 Vd NA 2.496 L/kg 1compartment NA NA Human Human +DTXSID2041547 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2041547 TK.Half.Life NA 21.39 hours 1compartment NA NA Human Human +DTXSID2041547 Css NA 1.144 mg/L 3compartmentss NA 50% Human Human +DTXSID2041547 Css NA 7.77 mg/L 3compartmentss NA 95% Human Human +DTXSID2041547 Css NA 0.7608 mg/L PBTK NA 50% Human Human +DTXSID2041547 Css NA 4.894 mg/L PBTK NA 95% Human Human +DTXSID2041547 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041547 Fup 0.0373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041547 Vd NA 1.868 L/kg 1compartment NA NA Rat Human DTXSID2041547 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2041547 TK.Half.Life NA 4.46 hours 1compartment NA NA Rat Human -DTXSID2041547 Css NA 0.5236 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041547 Css NA 2.755 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041547 Css NA 0.3396 mg/L PBTK NA 50% Rat Human -DTXSID2041547 Css NA 1.73 mg/L PBTK NA 95% Rat Human -DTXSID2041622 Clint NA 540.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041622 Fup NA 0.0243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041622 Vd NA 2.651 L/kg 1compartment NA NA Human Human -DTXSID2041622 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041622 TK.Half.Life NA 3.428 hours 1compartment NA NA Human Human -DTXSID2041622 Css NA 0.06771 mg/L 3compartmentss NA 50% Human Human -DTXSID2041622 Css NA 0.486 mg/L 3compartmentss NA 95% Human Human -DTXSID2041622 Css NA 0.04566 mg/L PBTK NA 50% Human Human -DTXSID2041622 Css NA 0.3164 mg/L PBTK NA 95% Human Human -DTXSID2041622 Clint NA 540.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041622 Fup NA 0.0243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041622 Vd NA 1.99 L/kg 1compartment NA NA Rat Human -DTXSID2041622 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041622 TK.Half.Life NA 0.9995 hours 1compartment NA NA Rat Human -DTXSID2041622 Css NA 0.03784 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041622 Css NA 0.2236 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041622 Css NA 0.02411 mg/L PBTK NA 50% Rat Human -DTXSID2041622 Css NA 0.1376 mg/L PBTK NA 95% Rat Human -DTXSID2041672 Clint NA 103.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041672 Fup NA 0.2727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041672 Vd NA 1.447 L/kg 1compartment NA NA Human Human +DTXSID2041547 TK.Half.Life NA 5.386 hours 1compartment NA NA Rat Human +DTXSID2041547 Css NA 0.1471 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041547 Css NA 0.8335 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041547 Css NA 0.09606 mg/L PBTK NA 50% Rat Human +DTXSID2041547 Css NA 0.524 mg/L PBTK NA 95% Rat Human +DTXSID2041591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041591 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041591 Vd NA 1.156 L/kg 1compartment NA NA Human Human +DTXSID2041591 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2041591 TK.Half.Life NA 16.06 hours 1compartment NA NA Human Human +DTXSID2041591 Css NA 1.395 mg/L 3compartmentss NA 50% Human Human +DTXSID2041591 Css NA 7.584 mg/L 3compartmentss NA 95% Human Human +DTXSID2041591 Css NA 1.156 mg/L PBTK NA 50% Human Human +DTXSID2041591 Css NA 5.036 mg/L PBTK NA 95% Human Human +DTXSID2041591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041591 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041591 Vd NA 1.027 L/kg 1compartment NA NA Rat Human +DTXSID2041591 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2041591 TK.Half.Life NA 4.554 hours 1compartment NA NA Rat Human +DTXSID2041591 Css NA 0.08672 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041591 Css NA 0.4308 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041591 Css NA 0.0718 mg/L PBTK NA 50% Rat Human +DTXSID2041591 Css NA 0.2711 mg/L PBTK NA 95% Rat Human +DTXSID2041622 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041622 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041622 Vd NA 3.032 L/kg 1compartment NA NA Human Human +DTXSID2041622 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2041622 TK.Half.Life NA 29.04 hours 1compartment NA NA Human Human +DTXSID2041622 Css NA 1.08 mg/L 3compartmentss NA 50% Human Human +DTXSID2041622 Css NA 6.91 mg/L 3compartmentss NA 95% Human Human +DTXSID2041622 Css NA 0.7607 mg/L PBTK NA 50% Human Human +DTXSID2041622 Css NA 4.678 mg/L PBTK NA 95% Human Human +DTXSID2041622 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041622 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041622 Vd NA 2.285 L/kg 1compartment NA NA Rat Human +DTXSID2041622 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2041622 TK.Half.Life NA 4.864 hours 1compartment NA NA Rat Human +DTXSID2041622 Css NA 0.1393 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041622 Css NA 0.7548 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041622 Css NA 0.09658 mg/L PBTK NA 50% Rat Human +DTXSID2041622 Css NA 0.5106 mg/L PBTK NA 95% Rat Human +DTXSID2041626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041626 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041626 Vd NA 1.365 L/kg 1compartment NA NA Human Human +DTXSID2041626 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2041626 TK.Half.Life NA 3.043 hours 1compartment NA NA Human Human +DTXSID2041626 Css NA 0.207 mg/L 3compartmentss NA 50% Human Human +DTXSID2041626 Css NA 1.668 mg/L 3compartmentss NA 95% Human Human +DTXSID2041626 Css NA 0.1395 mg/L PBTK NA 50% Human Human +DTXSID2041626 Css NA 1.051 mg/L PBTK NA 95% Human Human +DTXSID2041626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041626 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041626 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID2041626 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2041626 TK.Half.Life NA 1.223 hours 1compartment NA NA Rat Human +DTXSID2041626 Css NA 0.0267 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041626 Css NA 0.1585 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041626 Css NA 0.01761 mg/L PBTK NA 50% Rat Human +DTXSID2041626 Css NA 0.09818 mg/L PBTK NA 95% Rat Human +DTXSID2041672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041672 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041672 Vd NA 1.048 L/kg 1compartment NA NA Human Human DTXSID2041672 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041672 TK.Half.Life NA 1.287 hours 1compartment NA NA Human Human -DTXSID2041672 Css NA 0.01934 mg/L 3compartmentss NA 50% Human Human -DTXSID2041672 Css NA 0.145 mg/L 3compartmentss NA 95% Human Human -DTXSID2041672 Css NA 0.01444 mg/L PBTK NA 50% Human Human -DTXSID2041672 Css NA 0.09822 mg/L PBTK NA 95% Human Human -DTXSID2041672 Clint NA 103.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041672 Fup NA 0.2727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041672 Vd NA 1.168 L/kg 1compartment NA NA Rat Human +DTXSID2041672 TK.Half.Life NA 1.555 hours 1compartment NA NA Human Human +DTXSID2041672 Css NA 0.08799 mg/L 3compartmentss NA 50% Human Human +DTXSID2041672 Css NA 0.6296 mg/L 3compartmentss NA 95% Human Human +DTXSID2041672 Css NA 0.06311 mg/L PBTK NA 50% Human Human +DTXSID2041672 Css NA 0.4164 mg/L PBTK NA 95% Human Human +DTXSID2041672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041672 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041672 Vd NA 0.8748 L/kg 1compartment NA NA Rat Human DTXSID2041672 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041672 TK.Half.Life NA 0.4744 hours 1compartment NA NA Rat Human -DTXSID2041672 Css NA 0.01051 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041672 Css NA 0.06338 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041672 Css NA 0.007556 mg/L PBTK NA 50% Rat Human -DTXSID2041672 Css NA 0.04266 mg/L PBTK NA 95% Rat Human -DTXSID2041703 Clint NA 11.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041703 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041703 Vd NA 0.2185 L/kg 1compartment NA NA Human Human -DTXSID2041703 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041703 TK.Half.Life NA 5.208 hours 1compartment NA NA Human Human -DTXSID2041703 Css NA 4.461 mg/L 3compartmentss NA 50% Human Human -DTXSID2041703 Css NA 40.25 mg/L 3compartmentss NA 95% Human Human -DTXSID2041703 Css NA 2.631 mg/L PBTK NA 50% Human Human -DTXSID2041703 Css NA 23.13 mg/L PBTK NA 95% Human Human -DTXSID2041703 Clint NA 11.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041703 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041703 Vd NA 0.2133 L/kg 1compartment NA NA Rat Human -DTXSID2041703 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041703 TK.Half.Life NA 3.332 hours 1compartment NA NA Rat Human -DTXSID2041703 Css NA 2.423 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041703 Css NA 17.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041703 Css NA 1.336 mg/L PBTK NA 50% Rat Human -DTXSID2041703 Css NA 9.593 mg/L PBTK NA 95% Rat Human -DTXSID2041709 Clint NA 169.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041709 Fup NA 0.0052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041709 Vd NA 0.1986 L/kg 1compartment NA NA Human Human +DTXSID2041672 TK.Half.Life NA 0.6796 hours 1compartment NA NA Rat Human +DTXSID2041672 Css NA 0.01103 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041672 Css NA 0.0621 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041672 Css NA 0.007905 mg/L PBTK NA 50% Rat Human +DTXSID2041672 Css NA 0.04048 mg/L PBTK NA 95% Rat Human +DTXSID2041709 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041709 Fup 0.0784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041709 Vd NA 0.238 L/kg 1compartment NA NA Human Human DTXSID2041709 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041709 TK.Half.Life NA 1.061 hours 1compartment NA NA Human Human -DTXSID2041709 Css NA 0.861 mg/L 3compartmentss NA 50% Human Human -DTXSID2041709 Css NA 8.689 mg/L 3compartmentss NA 95% Human Human -DTXSID2041709 Css NA 0.5028 mg/L PBTK NA 50% Human Human -DTXSID2041709 Css NA 5.02 mg/L PBTK NA 95% Human Human -DTXSID2041709 Clint NA 169.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041709 Fup NA 0.0052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041709 Vd NA 0.1928 L/kg 1compartment NA NA Rat Human +DTXSID2041709 TK.Half.Life NA 0.7424 hours 1compartment NA NA Human Human +DTXSID2041709 Css NA 0.3872 mg/L 3compartmentss NA 50% Human Human +DTXSID2041709 Css NA 3.111 mg/L 3compartmentss NA 95% Human Human +DTXSID2041709 Css NA 0.233 mg/L PBTK NA 50% Human Human +DTXSID2041709 Css NA 1.814 mg/L PBTK NA 95% Human Human +DTXSID2041709 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041709 Fup 0.0784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041709 Vd NA 0.2419 L/kg 1compartment NA NA Rat Human DTXSID2041709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041709 TK.Half.Life NA 0.6717 hours 1compartment NA NA Rat Human -DTXSID2041709 Css NA 0.5003 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041709 Css NA 4.301 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041709 Css NA 0.2732 mg/L PBTK NA 50% Rat Human -DTXSID2041709 Css NA 2.34 mg/L PBTK NA 95% Rat Human -DTXSID2041759 Clint NA 74.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041759 Fup NA 0.3626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041759 Vd NA 5.237 L/kg 1compartment NA NA Human Human -DTXSID2041759 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041759 TK.Half.Life NA 2.713 hours 1compartment NA NA Human Human -DTXSID2041759 Css NA 0.004866 mg/L 3compartmentss NA 50% Human Human -DTXSID2041759 Css NA 0.03419 mg/L 3compartmentss NA 95% Human Human -DTXSID2041759 Css NA 0.005891 mg/L PBTK NA 50% Human Human -DTXSID2041759 Css NA 0.03646 mg/L PBTK NA 95% Human Human -DTXSID2041759 Clint NA 74.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041759 Fup NA 0.3626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041759 Vd NA 4.735 L/kg 1compartment NA NA Rat Human -DTXSID2041759 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041759 TK.Half.Life NA 1.002 hours 1compartment NA NA Rat Human -DTXSID2041759 Css NA 0.002602 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041759 Css NA 0.01548 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041759 Css NA 0.003149 mg/L PBTK NA 50% Rat Human -DTXSID2041759 Css NA 0.01698 mg/L PBTK NA 95% Rat Human -DTXSID2041880 Clint NA 1370 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041880 Fup NA 0.504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041880 Vd NA 0.6897 L/kg 1compartment NA NA Human Human +DTXSID2041709 TK.Half.Life NA 0.4572 hours 1compartment NA NA Rat Human +DTXSID2041709 Css NA 0.05088 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041709 Css NA 0.3031 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041709 Css NA 0.02964 mg/L PBTK NA 50% Rat Human +DTXSID2041709 Css NA 0.1725 mg/L PBTK NA 95% Rat Human +DTXSID20417439 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20417439 Fup 0.0434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20417439 Vd NA 2.046 L/kg 1compartment NA NA Human Human +DTXSID20417439 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20417439 TK.Half.Life NA 12.45 hours 1compartment NA NA Human Human +DTXSID20417439 Css NA 0.8072 mg/L 3compartmentss NA 50% Human Human +DTXSID20417439 Css NA 6.456 mg/L 3compartmentss NA 95% Human Human +DTXSID20417439 Css NA 0.5262 mg/L PBTK NA 50% Human Human +DTXSID20417439 Css NA 4.058 mg/L PBTK NA 95% Human Human +DTXSID20417439 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20417439 Fup 0.0434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20417439 Vd NA 1.533 L/kg 1compartment NA NA Rat Human +DTXSID20417439 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20417439 TK.Half.Life NA 3.995 hours 1compartment NA NA Rat Human +DTXSID20417439 Css NA 0.1044 mg/L 3compartmentss NA 50% Rat Human +DTXSID20417439 Css NA 0.6322 mg/L 3compartmentss NA 95% Rat Human +DTXSID20417439 Css NA 0.0671 mg/L PBTK NA 50% Rat Human +DTXSID20417439 Css NA 0.3852 mg/L PBTK NA 95% Rat Human +DTXSID2041880 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041880 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041880 Vd NA 0.7766 L/kg 1compartment NA NA Human Human DTXSID2041880 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041880 TK.Half.Life NA 0.4735 hours 1compartment NA NA Human Human -DTXSID2041880 Css NA 0.0006706 mg/L 3compartmentss NA 50% Human Human -DTXSID2041880 Css NA 0.006537 mg/L 3compartmentss NA 95% Human Human -DTXSID2041880 Css NA 0.0005175 mg/L PBTK NA 50% Human Human -DTXSID2041880 Css NA 0.004448 mg/L PBTK NA 95% Human Human -DTXSID2041880 Clint NA 1370 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041880 Fup NA 0.504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041880 Vd NA 0.6835 L/kg 1compartment NA NA Rat Human +DTXSID2041880 TK.Half.Life NA 7.804 hours 1compartment NA NA Human Human +DTXSID2041880 Css NA 1.099 mg/L 3compartmentss NA 50% Human Human +DTXSID2041880 Css NA 7.6 mg/L 3compartmentss NA 95% Human Human +DTXSID2041880 Css NA 0.8971 mg/L PBTK NA 50% Human Human +DTXSID2041880 Css NA 4.79 mg/L PBTK NA 95% Human Human +DTXSID2041880 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041880 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041880 Vd NA 0.7755 L/kg 1compartment NA NA Rat Human DTXSID2041880 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041880 TK.Half.Life NA 0.2036 hours 1compartment NA NA Rat Human -DTXSID2041880 Css NA 0.0003674 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041880 Css NA 0.003128 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041880 Css NA 0.000274 mg/L PBTK NA 50% Rat Human -DTXSID2041880 Css NA 0.002053 mg/L PBTK NA 95% Rat Human -DTXSID2041884 Clint NA 983.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041884 Fup NA 0.0339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041884 Vd NA 2.829 L/kg 1compartment NA NA Human Human -DTXSID2041884 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041884 TK.Half.Life NA 3.068 hours 1compartment NA NA Human Human -DTXSID2041884 Css NA 0.03566 mg/L 3compartmentss NA 50% Human Human -DTXSID2041884 Css NA 0.237 mg/L 3compartmentss NA 95% Human Human -DTXSID2041884 Css NA 0.02435 mg/L PBTK NA 50% Human Human -DTXSID2041884 Css NA 0.1563 mg/L PBTK NA 95% Human Human -DTXSID2041884 Clint NA 983.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041884 Fup NA 0.0339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041884 Vd NA 2.118 L/kg 1compartment NA NA Rat Human -DTXSID2041884 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041884 TK.Half.Life NA 0.9023 hours 1compartment NA NA Rat Human -DTXSID2041884 Css NA 0.0201 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041884 Css NA 0.111 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041884 Css NA 0.01303 mg/L PBTK NA 50% Rat Human -DTXSID2041884 Css NA 0.0703 mg/L PBTK NA 95% Rat Human -DTXSID2041886 Clint NA 581.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041886 Fup NA 0.2996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041886 Vd NA 0.4227 L/kg 1compartment NA NA Human Human +DTXSID2041880 TK.Half.Life NA 2.639 hours 1compartment NA NA Rat Human +DTXSID2041880 Css NA 0.0672 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041880 Css NA 0.4146 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041880 Css NA 0.05488 mg/L PBTK NA 50% Rat Human +DTXSID2041880 Css NA 0.2549 mg/L PBTK NA 95% Rat Human +DTXSID2041884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041884 Fup 0.013 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041884 Vd NA 2.45 L/kg 1compartment NA NA Human Human +DTXSID2041884 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2041884 TK.Half.Life NA 37.41 hours 1compartment NA NA Human Human +DTXSID2041884 Css NA 2.176 mg/L 3compartmentss NA 50% Human Human +DTXSID2041884 Css NA 16.71 mg/L 3compartmentss NA 95% Human Human +DTXSID2041884 Css NA 1.432 mg/L PBTK NA 50% Human Human +DTXSID2041884 Css NA 10.51 mg/L PBTK NA 95% Human Human +DTXSID2041884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041884 Fup 0.013 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041884 Vd NA 1.824 L/kg 1compartment NA NA Rat Human +DTXSID2041884 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2041884 TK.Half.Life NA 9.485 hours 1compartment NA NA Rat Human +DTXSID2041884 Css NA 0.2827 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041884 Css NA 1.788 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041884 Css NA 0.1829 mg/L PBTK NA 50% Rat Human +DTXSID2041884 Css NA 1.097 mg/L PBTK NA 95% Rat Human +DTXSID2041886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041886 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041886 Vd NA 0.5063 L/kg 1compartment NA NA Human Human DTXSID2041886 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041886 TK.Half.Life NA 0.3511 hours 1compartment NA NA Human Human -DTXSID2041886 Css NA 0.00295 mg/L 3compartmentss NA 50% Human Human -DTXSID2041886 Css NA 0.02265 mg/L 3compartmentss NA 95% Human Human -DTXSID2041886 Css NA 0.001985 mg/L PBTK NA 50% Human Human -DTXSID2041886 Css NA 0.01446 mg/L PBTK NA 95% Human Human -DTXSID2041886 Clint NA 581.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041886 Fup NA 0.2996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041886 Vd NA 0.4155 L/kg 1compartment NA NA Rat Human +DTXSID2041886 TK.Half.Life NA 0.5691 hours 1compartment NA NA Human Human +DTXSID2041886 Css NA 0.04784 mg/L 3compartmentss NA 50% Human Human +DTXSID2041886 Css NA 0.4109 mg/L 3compartmentss NA 95% Human Human +DTXSID2041886 Css NA 0.03411 mg/L PBTK NA 50% Human Human +DTXSID2041886 Css NA 0.2654 mg/L PBTK NA 95% Human Human +DTXSID2041886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041886 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041886 Vd NA 0.4989 L/kg 1compartment NA NA Rat Human DTXSID2041886 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041886 TK.Half.Life NA 0.152 hours 1compartment NA NA Rat Human -DTXSID2041886 Css NA 0.001616 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041886 Css NA 0.0101 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041886 Css NA 0.001041 mg/L PBTK NA 50% Rat Human -DTXSID2041886 Css NA 0.006232 mg/L PBTK NA 95% Rat Human -DTXSID2041913 Clint NA 17.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041913 Fup NA 0.0489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041913 Vd NA 1.55 L/kg 1compartment NA NA Human Human +DTXSID2041886 TK.Half.Life NA 0.2854 hours 1compartment NA NA Rat Human +DTXSID2041886 Css NA 0.005996 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041886 Css NA 0.03875 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041886 Css NA 0.004228 mg/L PBTK NA 50% Rat Human +DTXSID2041886 Css NA 0.0247 mg/L PBTK NA 95% Rat Human +DTXSID2041913 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041913 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041913 Vd NA 2.08 L/kg 1compartment NA NA Human Human DTXSID2041913 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041913 TK.Half.Life NA 8.828 hours 1compartment NA NA Human Human -DTXSID2041913 Css NA 0.8114 mg/L 3compartmentss NA 50% Human Human -DTXSID2041913 Css NA 6.362 mg/L 3compartmentss NA 95% Human Human -DTXSID2041913 Css NA 0.5224 mg/L PBTK NA 50% Human Human -DTXSID2041913 Css NA 3.862 mg/L PBTK NA 95% Human Human -DTXSID2041913 Clint NA 17.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041913 Fup NA 0.0489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041913 Vd NA 1.164 L/kg 1compartment NA NA Rat Human +DTXSID2041913 TK.Half.Life NA 6.836 hours 1compartment NA NA Human Human +DTXSID2041913 Css NA 0.3578 mg/L 3compartmentss NA 50% Human Human +DTXSID2041913 Css NA 2.494 mg/L 3compartmentss NA 95% Human Human +DTXSID2041913 Css NA 0.2432 mg/L PBTK NA 50% Human Human +DTXSID2041913 Css NA 1.607 mg/L PBTK NA 95% Human Human +DTXSID2041913 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041913 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041913 Vd NA 1.575 L/kg 1compartment NA NA Rat Human DTXSID2041913 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041913 TK.Half.Life NA 3.358 hours 1compartment NA NA Rat Human -DTXSID2041913 Css NA 0.4505 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041913 Css NA 2.681 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041913 Css NA 0.2716 mg/L PBTK NA 50% Rat Human -DTXSID2041913 Css NA 1.532 mg/L PBTK NA 95% Rat Human -DTXSID2041917 Clint NA 0.2098 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041917 Fup NA 0.9208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2041917 Vd NA 1.743 L/kg 1compartment NA NA Human Human -DTXSID2041917 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2041917 TK.Half.Life NA 9.146 hours 1compartment NA NA Human Human -DTXSID2041917 Css NA 0.5646 mg/L 3compartmentss NA 50% Human Human -DTXSID2041917 Css NA 3.659 mg/L 3compartmentss NA 95% Human Human -DTXSID2041917 Css NA 0.55 mg/L PBTK NA 50% Human Human -DTXSID2041917 Css NA 2.516 mg/L PBTK NA 95% Human Human -DTXSID2041917 Clint NA 0.2098 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041917 Fup NA 0.9208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2041917 Vd NA 1.78 L/kg 1compartment NA NA Rat Human +DTXSID2041913 TK.Half.Life NA 2.206 hours 1compartment NA NA Rat Human +DTXSID2041913 Css NA 0.04543 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041913 Css NA 0.2607 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041913 Css NA 0.03034 mg/L PBTK NA 50% Rat Human +DTXSID2041913 Css NA 0.1646 mg/L PBTK NA 95% Rat Human +DTXSID2041917 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041917 Fup 0.672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2041917 Vd NA 1.426 L/kg 1compartment NA NA Human Human +DTXSID2041917 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2041917 TK.Half.Life NA 13.73 hours 1compartment NA NA Human Human +DTXSID2041917 Css NA 0.5316 mg/L 3compartmentss NA 50% Human Human +DTXSID2041917 Css NA 3.966 mg/L 3compartmentss NA 95% Human Human +DTXSID2041917 Css NA 0.4897 mg/L PBTK NA 50% Human Human +DTXSID2041917 Css NA 2.639 mg/L PBTK NA 95% Human Human +DTXSID2041917 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041917 Fup 0.672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2041917 Vd NA 1.452 L/kg 1compartment NA NA Rat Human DTXSID2041917 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2041917 TK.Half.Life NA 3.654 hours 1compartment NA NA Rat Human -DTXSID2041917 Css NA 0.1643 mg/L 3compartmentss NA 50% Rat Human -DTXSID2041917 Css NA 1.032 mg/L 3compartmentss NA 95% Rat Human -DTXSID2041917 Css NA 0.1593 mg/L PBTK NA 50% Rat Human -DTXSID2041917 Css NA 0.6636 mg/L PBTK NA 95% Rat Human +DTXSID2041917 TK.Half.Life NA 4.764 hours 1compartment NA NA Rat Human +DTXSID2041917 Css NA 0.002746 mg/L 3compartmentss NA 50% Rat Human +DTXSID2041917 Css NA 0.02178 mg/L 3compartmentss NA 95% Rat Human +DTXSID2041917 Css NA 0.002483 mg/L PBTK NA 50% Rat Human +DTXSID2041917 Css NA 0.01403 mg/L PBTK NA 95% Rat Human DTXSID2042014 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2042014 Fup NA 0.812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042014 Vd NA 0.4421 L/kg 1compartment NA NA Human Human +DTXSID2042014 Vd NA 0.4458 L/kg 1compartment NA NA Human Human DTXSID2042014 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2042014 TK.Half.Life NA 3.522 hours 1compartment NA NA Human Human -DTXSID2042014 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human -DTXSID2042014 Css NA 6.109 mg/L 3compartmentss NA 95% Human Human -DTXSID2042014 Css NA 0.8088 mg/L PBTK NA 50% Human Human -DTXSID2042014 Css NA 3.837 mg/L PBTK NA 95% Human Human +DTXSID2042014 TK.Half.Life NA 3.551 hours 1compartment NA NA Human Human +DTXSID2042014 Css NA 0.944 mg/L 3compartmentss NA 50% Human Human +DTXSID2042014 Css NA 5.117 mg/L 3compartmentss NA 95% Human Human +DTXSID2042014 Css NA 0.6939 mg/L PBTK NA 50% Human Human +DTXSID2042014 Css NA 3.206 mg/L PBTK NA 95% Human Human DTXSID2042014 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2042014 Fup NA 0.812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042014 Vd NA 0.4646 L/kg 1compartment NA NA Rat Human +DTXSID2042014 Vd NA 0.4677 L/kg 1compartment NA NA Rat Human DTXSID2042014 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042014 TK.Half.Life NA 1.261 hours 1compartment NA NA Rat Human -DTXSID2042014 Css NA 0.2859 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042014 Css NA 1.541 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042014 Css NA 0.2002 mg/L PBTK NA 50% Rat Human -DTXSID2042014 Css NA 0.8878 mg/L PBTK NA 95% Rat Human -DTXSID2042060 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042060 Fup NA 0.2953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042060 Vd NA 2.695 L/kg 1compartment NA NA Human Human -DTXSID2042060 Days.Css NA 47 Days PBTK NA NA Human Human -DTXSID2042060 TK.Half.Life NA 222.9 hours 1compartment NA NA Human Human -DTXSID2042060 Css NA 8.956 mg/L 3compartmentss NA 50% Human Human -DTXSID2042060 Css NA 27.38 mg/L 3compartmentss NA 95% Human Human -DTXSID2042060 Css NA 6.67 mg/L PBTK NA 50% Human Human -DTXSID2042060 Css NA 18.45 mg/L PBTK NA 95% Human Human -DTXSID2042060 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042060 Fup NA 0.2953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042060 Vd NA 2.059 L/kg 1compartment NA NA Rat Human -DTXSID2042060 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID2042060 TK.Half.Life NA 25.55 hours 1compartment NA NA Rat Human -DTXSID2042060 Css NA 2.443 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042060 Css NA 5.836 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042060 Css NA 1.752 mg/L PBTK NA 50% Rat Human -DTXSID2042060 Css NA 3.648 mg/L PBTK NA 95% Rat Human -DTXSID2042143 Clint NA 96.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042143 Fup NA 0.0741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042143 Vd NA 2.091 L/kg 1compartment NA NA Human Human +DTXSID2042014 TK.Half.Life NA 1.27 hours 1compartment NA NA Rat Human +DTXSID2042014 Css NA 0.01753 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042014 Css NA 0.1258 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042014 Css NA 0.01232 mg/L PBTK NA 50% Rat Human +DTXSID2042014 Css NA 0.07776 mg/L PBTK NA 95% Rat Human +DTXSID2042060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042060 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042060 Vd NA 2.602 L/kg 1compartment NA NA Human Human +DTXSID2042060 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2042060 TK.Half.Life NA 6.601 hours 1compartment NA NA Human Human +DTXSID2042060 Css NA 0.2102 mg/L 3compartmentss NA 50% Human Human +DTXSID2042060 Css NA 1.333 mg/L 3compartmentss NA 95% Human Human +DTXSID2042060 Css NA 0.154 mg/L PBTK NA 50% Human Human +DTXSID2042060 Css NA 0.9334 mg/L PBTK NA 95% Human Human +DTXSID2042060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042060 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042060 Vd NA 1.985 L/kg 1compartment NA NA Rat Human +DTXSID2042060 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2042060 TK.Half.Life NA 1.757 hours 1compartment NA NA Rat Human +DTXSID2042060 Css NA 0.02632 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042060 Css NA 0.1295 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042060 Css NA 0.01928 mg/L PBTK NA 50% Rat Human +DTXSID2042060 Css NA 0.09105 mg/L PBTK NA 95% Rat Human +DTXSID2042143 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042143 Fup 0.0901 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042143 Vd NA 2.488 L/kg 1compartment NA NA Human Human DTXSID2042143 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2042143 TK.Half.Life NA 3.378 hours 1compartment NA NA Human Human -DTXSID2042143 Css NA 0.1198 mg/L 3compartmentss NA 50% Human Human -DTXSID2042143 Css NA 0.871 mg/L 3compartmentss NA 95% Human Human -DTXSID2042143 Css NA 0.08002 mg/L PBTK NA 50% Human Human -DTXSID2042143 Css NA 0.5514 mg/L PBTK NA 95% Human Human -DTXSID2042143 Clint NA 96.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042143 Fup NA 0.0741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042143 Vd NA 1.574 L/kg 1compartment NA NA Rat Human +DTXSID2042143 TK.Half.Life NA 11.72 hours 1compartment NA NA Human Human +DTXSID2042143 Css NA 0.5348 mg/L 3compartmentss NA 50% Human Human +DTXSID2042143 Css NA 3.598 mg/L 3compartmentss NA 95% Human Human +DTXSID2042143 Css NA 0.3677 mg/L PBTK NA 50% Human Human +DTXSID2042143 Css NA 2.395 mg/L PBTK NA 95% Human Human +DTXSID2042143 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042143 Fup 0.0901 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042143 Vd NA 1.873 L/kg 1compartment NA NA Rat Human DTXSID2042143 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042143 TK.Half.Life NA 1.095 hours 1compartment NA NA Rat Human -DTXSID2042143 Css NA 0.06828 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042143 Css NA 0.3929 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042143 Css NA 0.04324 mg/L PBTK NA 50% Rat Human -DTXSID2042143 Css NA 0.2375 mg/L PBTK NA 95% Rat Human -DTXSID2042145 Clint NA 1.729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042145 Fup NA 0.5498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042145 Vd NA 1.911 L/kg 1compartment NA NA Human Human -DTXSID2042145 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2042145 TK.Half.Life NA 8.714 hours 1compartment NA NA Human Human -DTXSID2042145 Css NA 0.4446 mg/L 3compartmentss NA 50% Human Human -DTXSID2042145 Css NA 2.727 mg/L 3compartmentss NA 95% Human Human -DTXSID2042145 Css NA 0.377 mg/L PBTK NA 50% Human Human -DTXSID2042145 Css NA 1.843 mg/L PBTK NA 95% Human Human -DTXSID2042145 Clint NA 1.729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042145 Fup NA 0.5498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042145 Vd NA 1.566 L/kg 1compartment NA NA Rat Human -DTXSID2042145 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042145 TK.Half.Life NA 2.942 hours 1compartment NA NA Rat Human -DTXSID2042145 Css NA 0.1924 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042145 Css NA 1.001 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042145 Css NA 0.1597 mg/L PBTK NA 50% Rat Human -DTXSID2042145 Css NA 0.6357 mg/L PBTK NA 95% Rat Human -DTXSID2042149 Clint NA 19.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042149 Fup NA 0.6938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042149 Vd NA 1.422 L/kg 1compartment NA NA Human Human -DTXSID2042149 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2042149 TK.Half.Life NA 1.208 hours 1compartment NA NA Human Human -DTXSID2042149 Css NA 0.03391 mg/L 3compartmentss NA 50% Human Human -DTXSID2042149 Css NA 0.3483 mg/L 3compartmentss NA 95% Human Human -DTXSID2042149 Css NA 0.02996 mg/L PBTK NA 50% Human Human -DTXSID2042149 Css NA 0.2533 mg/L PBTK NA 95% Human Human -DTXSID2042149 Clint NA 19.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042149 Fup NA 0.6938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042149 Vd NA 1.258 L/kg 1compartment NA NA Rat Human +DTXSID2042143 TK.Half.Life NA 3.079 hours 1compartment NA NA Rat Human +DTXSID2042143 Css NA 0.06896 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042143 Css NA 0.3725 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042143 Css NA 0.0465 mg/L PBTK NA 50% Rat Human +DTXSID2042143 Css NA 0.2388 mg/L PBTK NA 95% Rat Human +DTXSID2042149 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042149 Fup 0.539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042149 Vd NA 1.508 L/kg 1compartment NA NA Human Human +DTXSID2042149 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2042149 TK.Half.Life NA 21.92 hours 1compartment NA NA Human Human +DTXSID2042149 Css NA 1.436 mg/L 3compartmentss NA 50% Human Human +DTXSID2042149 Css NA 8.193 mg/L 3compartmentss NA 95% Human Human +DTXSID2042149 Css NA 1.22 mg/L PBTK NA 50% Human Human +DTXSID2042149 Css NA 5.477 mg/L PBTK NA 95% Human Human +DTXSID2042149 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042149 Fup 0.539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042149 Vd NA 1.283 L/kg 1compartment NA NA Rat Human DTXSID2042149 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042149 TK.Half.Life NA 0.5146 hours 1compartment NA NA Rat Human -DTXSID2042149 Css NA 0.0173 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042149 Css NA 0.1516 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042149 Css NA 0.01504 mg/L PBTK NA 50% Rat Human -DTXSID2042149 Css NA 0.1042 mg/L PBTK NA 95% Rat Human -DTXSID2042191 Clint NA 2.706 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042191 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042191 Vd NA 0.8962 L/kg 1compartment NA NA Human Human +DTXSID2042149 TK.Half.Life NA 5.514 hours 1compartment NA NA Rat Human +DTXSID2042149 Css NA 0.0893 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042149 Css NA 0.4664 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042149 Css NA 0.07599 mg/L PBTK NA 50% Rat Human +DTXSID2042149 Css NA 0.295 mg/L PBTK NA 95% Rat Human +DTXSID2042191 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042191 Fup 0.753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042191 Vd NA 0.7536 L/kg 1compartment NA NA Human Human DTXSID2042191 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2042191 TK.Half.Life NA 1.39 hours 1compartment NA NA Human Human -DTXSID2042191 Css NA 0.1528 mg/L 3compartmentss NA 50% Human Human -DTXSID2042191 Css NA 1.226 mg/L 3compartmentss NA 95% Human Human -DTXSID2042191 Css NA 0.1309 mg/L PBTK NA 50% Human Human -DTXSID2042191 Css NA 0.8812 mg/L PBTK NA 95% Human Human -DTXSID2042191 Clint NA 2.706 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042191 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042191 Vd NA 0.9171 L/kg 1compartment NA NA Rat Human +DTXSID2042191 TK.Half.Life NA 6.496 hours 1compartment NA NA Human Human +DTXSID2042191 Css NA 0.8734 mg/L 3compartmentss NA 50% Human Human +DTXSID2042191 Css NA 5.501 mg/L 3compartmentss NA 95% Human Human +DTXSID2042191 Css NA 0.7196 mg/L PBTK NA 50% Human Human +DTXSID2042191 Css NA 3.513 mg/L PBTK NA 95% Human Human +DTXSID2042191 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042191 Fup 0.753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042191 Vd NA 0.7702 L/kg 1compartment NA NA Rat Human DTXSID2042191 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042191 TK.Half.Life NA 0.7403 hours 1compartment NA NA Rat Human -DTXSID2042191 Css NA 0.06578 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042191 Css NA 0.4595 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042191 Css NA 0.05636 mg/L PBTK NA 50% Rat Human -DTXSID2042191 Css NA 0.2841 mg/L PBTK NA 95% Rat Human -DTXSID2042195 Clint NA 11.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042195 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042195 Vd NA 0.231 L/kg 1compartment NA NA Human Human +DTXSID2042191 TK.Half.Life NA 2.257 hours 1compartment NA NA Rat Human +DTXSID2042191 Css NA 0.01657 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042191 Css NA 0.1323 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042191 Css NA 0.01314 mg/L PBTK NA 50% Rat Human +DTXSID2042191 Css NA 0.08452 mg/L PBTK NA 95% Rat Human +DTXSID2042195 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042195 Fup 0.0412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042195 Vd NA 0.2642 L/kg 1compartment NA NA Human Human DTXSID2042195 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2042195 TK.Half.Life NA 3.067 hours 1compartment NA NA Human Human -DTXSID2042195 Css NA 2.351 mg/L 3compartmentss NA 50% Human Human -DTXSID2042195 Css NA 20.77 mg/L 3compartmentss NA 95% Human Human -DTXSID2042195 Css NA 1.402 mg/L PBTK NA 50% Human Human -DTXSID2042195 Css NA 12.08 mg/L PBTK NA 95% Human Human -DTXSID2042195 Clint NA 11.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042195 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042195 Vd NA 0.2259 L/kg 1compartment NA NA Rat Human +DTXSID2042195 TK.Half.Life NA 3.864 hours 1compartment NA NA Human Human +DTXSID2042195 Css NA 2.521 mg/L 3compartmentss NA 50% Human Human +DTXSID2042195 Css NA 20.72 mg/L 3compartmentss NA 95% Human Human +DTXSID2042195 Css NA 1.519 mg/L PBTK NA 50% Human Human +DTXSID2042195 Css NA 12.14 mg/L PBTK NA 95% Human Human +DTXSID2042195 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042195 Fup 0.0412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042195 Vd NA 0.2584 L/kg 1compartment NA NA Rat Human DTXSID2042195 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042195 TK.Half.Life NA 1.945 hours 1compartment NA NA Rat Human -DTXSID2042195 Css NA 1.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042195 Css NA 9.021 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042195 Css NA 0.7236 mg/L PBTK NA 50% Rat Human -DTXSID2042195 Css NA 4.907 mg/L PBTK NA 95% Rat Human -DTXSID2042199 Clint NA 0.1829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042199 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042199 Vd NA 0.8964 L/kg 1compartment NA NA Human Human -DTXSID2042199 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2042199 TK.Half.Life NA 4.498 hours 1compartment NA NA Human Human -DTXSID2042199 Css NA 0.604 mg/L 3compartmentss NA 50% Human Human -DTXSID2042199 Css NA 4.063 mg/L 3compartmentss NA 95% Human Human -DTXSID2042199 Css NA 0.5257 mg/L PBTK NA 50% Human Human -DTXSID2042199 Css NA 2.601 mg/L PBTK NA 95% Human Human -DTXSID2042199 Clint NA 0.1829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042199 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042199 Vd NA 0.917 L/kg 1compartment NA NA Rat Human -DTXSID2042199 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042199 TK.Half.Life NA 1.769 hours 1compartment NA NA Rat Human -DTXSID2042199 Css NA 0.1747 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042199 Css NA 1.139 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042199 Css NA 0.1498 mg/L PBTK NA 50% Rat Human -DTXSID2042199 Css NA 0.6912 mg/L PBTK NA 95% Rat Human -DTXSID2042220 Clint NA 38.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042220 Fup NA 0.041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042220 Vd NA 1.546 L/kg 1compartment NA NA Human Human +DTXSID2042195 TK.Half.Life NA 2.371 hours 1compartment NA NA Rat Human +DTXSID2042195 Css NA 0.3126 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042195 Css NA 1.94 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042195 Css NA 0.1827 mg/L PBTK NA 50% Rat Human +DTXSID2042195 Css NA 1.098 mg/L PBTK NA 95% Rat Human +DTXSID2042220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042220 Fup 0.0423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042220 Vd NA 1.566 L/kg 1compartment NA NA Human Human DTXSID2042220 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2042220 TK.Half.Life NA 5.407 hours 1compartment NA NA Human Human -DTXSID2042220 Css NA 0.4612 mg/L 3compartmentss NA 50% Human Human -DTXSID2042220 Css NA 3.945 mg/L 3compartmentss NA 95% Human Human -DTXSID2042220 Css NA 0.2932 mg/L PBTK NA 50% Human Human -DTXSID2042220 Css NA 2.429 mg/L PBTK NA 95% Human Human -DTXSID2042220 Clint NA 38.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042220 Fup NA 0.041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042220 Vd NA 1.158 L/kg 1compartment NA NA Rat Human +DTXSID2042220 TK.Half.Life NA 8.434 hours 1compartment NA NA Human Human +DTXSID2042220 Css NA 0.7568 mg/L 3compartmentss NA 50% Human Human +DTXSID2042220 Css NA 6.323 mg/L 3compartmentss NA 95% Human Human +DTXSID2042220 Css NA 0.4858 mg/L PBTK NA 50% Human Human +DTXSID2042220 Css NA 3.938 mg/L PBTK NA 95% Human Human +DTXSID2042220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042220 Fup 0.0423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042220 Vd NA 1.174 L/kg 1compartment NA NA Rat Human DTXSID2042220 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042220 TK.Half.Life NA 2.041 hours 1compartment NA NA Rat Human -DTXSID2042220 Css NA 0.2588 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042220 Css NA 1.877 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042220 Css NA 0.1551 mg/L PBTK NA 50% Rat Human -DTXSID2042220 Css NA 1.059 mg/L PBTK NA 95% Rat Human -DTXSID2042224 Clint NA 15.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042224 Fup NA 0.0474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042224 Vd NA 2.566 L/kg 1compartment NA NA Human Human -DTXSID2042224 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2042224 TK.Half.Life NA 27.19 hours 1compartment NA NA Human Human -DTXSID2042224 Css NA 1.418 mg/L 3compartmentss NA 50% Human Human -DTXSID2042224 Css NA 9.048 mg/L 3compartmentss NA 95% Human Human -DTXSID2042224 Css NA 0.9554 mg/L PBTK NA 50% Human Human -DTXSID2042224 Css NA 5.886 mg/L PBTK NA 95% Human Human -DTXSID2042224 Clint NA 15.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042224 Fup NA 0.0474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042224 Vd NA 1.923 L/kg 1compartment NA NA Rat Human -DTXSID2042224 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2042224 TK.Half.Life NA 6.472 hours 1compartment NA NA Rat Human -DTXSID2042224 Css NA 0.7834 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042224 Css NA 3.958 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042224 Css NA 0.5022 mg/L PBTK NA 50% Rat Human -DTXSID2042224 Css NA 2.472 mg/L PBTK NA 95% Rat Human -DTXSID2042276 Clint NA 5.941 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042276 Fup NA 0.4701 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042276 Vd NA 1.352 L/kg 1compartment NA NA Human Human +DTXSID2042220 TK.Half.Life NA 3.194 hours 1compartment NA NA Rat Human +DTXSID2042220 Css NA 0.09983 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042220 Css NA 0.6452 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042220 Css NA 0.06201 mg/L PBTK NA 50% Rat Human +DTXSID2042220 Css NA 0.3864 mg/L PBTK NA 95% Rat Human +DTXSID2042276 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042276 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042276 Vd NA 1.114 L/kg 1compartment NA NA Human Human DTXSID2042276 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2042276 TK.Half.Life NA 2.648 hours 1compartment NA NA Human Human -DTXSID2042276 Css NA 0.1553 mg/L 3compartmentss NA 50% Human Human -DTXSID2042276 Css NA 1.071 mg/L 3compartmentss NA 95% Human Human -DTXSID2042276 Css NA 0.1272 mg/L PBTK NA 50% Human Human -DTXSID2042276 Css NA 0.7403 mg/L PBTK NA 95% Human Human -DTXSID2042276 Clint NA 5.941 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042276 Fup NA 0.4701 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042276 Vd NA 1.155 L/kg 1compartment NA NA Rat Human +DTXSID2042276 TK.Half.Life NA 1.389 hours 1compartment NA NA Human Human +DTXSID2042276 Css NA 0.06154 mg/L 3compartmentss NA 50% Human Human +DTXSID2042276 Css NA 0.4839 mg/L 3compartmentss NA 95% Human Human +DTXSID2042276 Css NA 0.04649 mg/L PBTK NA 50% Human Human +DTXSID2042276 Css NA 0.3371 mg/L PBTK NA 95% Human Human +DTXSID2042276 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042276 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042276 Vd NA 0.9485 L/kg 1compartment NA NA Rat Human DTXSID2042276 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042276 TK.Half.Life NA 1.165 hours 1compartment NA NA Rat Human -DTXSID2042276 Css NA 0.07612 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042276 Css NA 0.4262 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042276 Css NA 0.06055 mg/L PBTK NA 50% Rat Human -DTXSID2042276 Css NA 0.2762 mg/L PBTK NA 95% Rat Human +DTXSID2042276 TK.Half.Life NA 0.6033 hours 1compartment NA NA Rat Human +DTXSID2042276 Css NA 0.007701 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042276 Css NA 0.04447 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042276 Css NA 0.005873 mg/L PBTK NA 50% Rat Human +DTXSID2042276 Css NA 0.02993 mg/L PBTK NA 95% Rat Human DTXSID2042436 Clint 1.05 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2042436 Fup 0.00942 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2042436 Vd NA 0.1779 L/kg 1compartment NA NA Human Human -DTXSID2042436 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID2042436 TK.Half.Life NA 44.6 hours 1compartment NA NA Human Human -DTXSID2042436 Css NA 26.97 mg/L 3compartmentss NA 50% Human Human -DTXSID2042436 Css NA 134.3 mg/L 3compartmentss NA 95% Human Human -DTXSID2042436 Css NA 15.74 mg/L PBTK NA 50% Human Human -DTXSID2042436 Css NA 76.73 mg/L PBTK NA 95% Human Human +DTXSID2042436 Vd NA 0.1746 L/kg 1compartment NA NA Human Human +DTXSID2042436 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID2042436 TK.Half.Life NA 43.87 hours 1compartment NA NA Human Human +DTXSID2042436 Css NA 10.94 mg/L 3compartmentss NA 50% Human Human +DTXSID2042436 Css NA 59.99 mg/L 3compartmentss NA 95% Human Human +DTXSID2042436 Css NA 6.438 mg/L PBTK NA 50% Human Human +DTXSID2042436 Css NA 34.51 mg/L PBTK NA 95% Human Human DTXSID2042436 Clint 1.05 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2042436 Fup 0.00942 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2042436 Vd NA 0.1743 L/kg 1compartment NA NA Rat Human +DTXSID2042436 Vd NA 0.1717 L/kg 1compartment NA NA Rat Human DTXSID2042436 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2042436 TK.Half.Life NA 22.12 hours 1compartment NA NA Rat Human -DTXSID2042436 Css NA 11.29 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042436 Css NA 45.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042436 Css NA 6.165 mg/L PBTK NA 50% Rat Human -DTXSID2042436 Css NA 24.83 mg/L PBTK NA 95% Rat Human -DTXSID2042517 Clint NA 0.4105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042517 Fup NA 0.1848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2042517 Vd NA 0.5108 L/kg 1compartment NA NA Human Human -DTXSID2042517 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2042517 TK.Half.Life NA 10.75 hours 1compartment NA NA Human Human -DTXSID2042517 Css NA 2.402 mg/L 3compartmentss NA 50% Human Human -DTXSID2042517 Css NA 9.866 mg/L 3compartmentss NA 95% Human Human -DTXSID2042517 Css NA 1.697 mg/L PBTK NA 50% Human Human -DTXSID2042517 Css NA 6.144 mg/L PBTK NA 95% Human Human -DTXSID2042517 Clint NA 0.4105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042517 Fup NA 0.1848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2042517 Vd NA 0.4856 L/kg 1compartment NA NA Rat Human -DTXSID2042517 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2042517 TK.Half.Life NA 4.362 hours 1compartment NA NA Rat Human -DTXSID2042517 Css NA 0.8603 mg/L 3compartmentss NA 50% Rat Human -DTXSID2042517 Css NA 2.851 mg/L 3compartmentss NA 95% Rat Human -DTXSID2042517 Css NA 0.5748 mg/L PBTK NA 50% Rat Human -DTXSID2042517 Css NA 1.671 mg/L PBTK NA 95% Rat Human -DTXSID2043747 Clint NA 423.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2043747 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2043747 Vd NA 3.683 L/kg 1compartment NA NA Human Human -DTXSID2043747 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2043747 TK.Half.Life NA 6.383 hours 1compartment NA NA Human Human -DTXSID2043747 Css NA 0.1409 mg/L 3compartmentss NA 50% Human Human -DTXSID2043747 Css NA 1.112 mg/L 3compartmentss NA 95% Human Human -DTXSID2043747 Css NA 0.1015 mg/L PBTK NA 50% Human Human -DTXSID2043747 Css NA 0.7427 mg/L PBTK NA 95% Human Human -DTXSID2043747 Clint NA 423.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2043747 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2043747 Vd NA 2.782 L/kg 1compartment NA NA Rat Human -DTXSID2043747 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2043747 TK.Half.Life NA 1.951 hours 1compartment NA NA Rat Human -DTXSID2043747 Css NA 0.07851 mg/L 3compartmentss NA 50% Rat Human -DTXSID2043747 Css NA 0.5621 mg/L 3compartmentss NA 95% Rat Human -DTXSID2043747 Css NA 0.05424 mg/L PBTK NA 50% Rat Human -DTXSID2043747 Css NA 0.3558 mg/L PBTK NA 95% Rat Human +DTXSID2042436 TK.Half.Life NA 21.81 hours 1compartment NA NA Rat Human +DTXSID2042436 Css NA 0.07786 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042436 Css NA 0.3535 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042436 Css NA 0.04256 mg/L PBTK NA 50% Rat Human +DTXSID2042436 Css NA 0.1919 mg/L PBTK NA 95% Rat Human +DTXSID2042511 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042511 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042511 Vd NA 2.547 L/kg 1compartment NA NA Human Human +DTXSID2042511 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2042511 TK.Half.Life NA 7.099 hours 1compartment NA NA Human Human +DTXSID2042511 Css NA 0.2414 mg/L 3compartmentss NA 50% Human Human +DTXSID2042511 Css NA 1.455 mg/L 3compartmentss NA 95% Human Human +DTXSID2042511 Css NA 0.1741 mg/L PBTK NA 50% Human Human +DTXSID2042511 Css NA 1.009 mg/L PBTK NA 95% Human Human +DTXSID2042511 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042511 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042511 Vd NA 1.938 L/kg 1compartment NA NA Rat Human +DTXSID2042511 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2042511 TK.Half.Life NA 1.913 hours 1compartment NA NA Rat Human +DTXSID2042511 Css NA 0.03056 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042511 Css NA 0.1473 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042511 Css NA 0.022 mg/L PBTK NA 50% Rat Human +DTXSID2042511 Css NA 0.104 mg/L PBTK NA 95% Rat Human +DTXSID2042648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2042648 Fup 0.77 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2042648 Vd NA 0.6603 L/kg 1compartment NA NA Human Human +DTXSID2042648 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2042648 TK.Half.Life NA 5.55 hours 1compartment NA NA Human Human +DTXSID2042648 Css NA 0.5566 mg/L 3compartmentss NA 50% Human Human +DTXSID2042648 Css NA 3.451 mg/L 3compartmentss NA 95% Human Human +DTXSID2042648 Css NA 0.4559 mg/L PBTK NA 50% Human Human +DTXSID2042648 Css NA 2.266 mg/L PBTK NA 95% Human Human +DTXSID2042648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2042648 Fup 0.77 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2042648 Vd NA 0.6808 L/kg 1compartment NA NA Rat Human +DTXSID2042648 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2042648 TK.Half.Life NA 1.949 hours 1compartment NA NA Rat Human +DTXSID2042648 Css NA 0.002842 mg/L 3compartmentss NA 50% Rat Human +DTXSID2042648 Css NA 0.02011 mg/L 3compartmentss NA 95% Rat Human +DTXSID2042648 Css NA 0.00226 mg/L PBTK NA 50% Rat Human +DTXSID2042648 Css NA 0.01256 mg/L PBTK NA 95% Rat Human +DTXSID20434520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20434520 Fup 0.0888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20434520 Vd NA 2.313 L/kg 1compartment NA NA Human Human +DTXSID20434520 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20434520 TK.Half.Life NA 9.746 hours 1compartment NA NA Human Human +DTXSID20434520 Css NA 0.477 mg/L 3compartmentss NA 50% Human Human +DTXSID20434520 Css NA 3.283 mg/L 3compartmentss NA 95% Human Human +DTXSID20434520 Css NA 0.3218 mg/L PBTK NA 50% Human Human +DTXSID20434520 Css NA 2.129 mg/L PBTK NA 95% Human Human +DTXSID20434520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20434520 Fup 0.0888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20434520 Vd NA 1.743 L/kg 1compartment NA NA Rat Human +DTXSID20434520 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20434520 TK.Half.Life NA 2.815 hours 1compartment NA NA Rat Human +DTXSID20434520 Css NA 0.05445 mg/L 3compartmentss NA 50% Rat Human +DTXSID20434520 Css NA 0.294 mg/L 3compartmentss NA 95% Rat Human +DTXSID20434520 Css NA 0.03649 mg/L PBTK NA 50% Rat Human +DTXSID20434520 Css NA 0.1875 mg/L PBTK NA 95% Rat Human +DTXSID2043828 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2043828 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2043828 Vd NA 3.809 L/kg 1compartment NA NA Human Human +DTXSID2043828 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2043828 TK.Half.Life NA 9.685 hours 1compartment NA NA Human Human +DTXSID2043828 Css NA 0.1622 mg/L 3compartmentss NA 50% Human Human +DTXSID2043828 Css NA 1.17 mg/L 3compartmentss NA 95% Human Human +DTXSID2043828 Css NA 0.1802 mg/L PBTK NA 50% Human Human +DTXSID2043828 Css NA 1.057 mg/L PBTK NA 95% Human Human +DTXSID2043828 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2043828 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2043828 Vd NA 3.675 L/kg 1compartment NA NA Rat Human +DTXSID2043828 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2043828 TK.Half.Life NA 4.699 hours 1compartment NA NA Rat Human +DTXSID2043828 Css NA 0.01884 mg/L 3compartmentss NA 50% Rat Human +DTXSID2043828 Css NA 0.09571 mg/L 3compartmentss NA 95% Rat Human +DTXSID2043828 Css NA 0.02176 mg/L PBTK NA 50% Rat Human +DTXSID2043828 Css NA 0.0862 mg/L PBTK NA 95% Rat Human DTXSID2043874 Clint NA 22.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2043874 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2043874 Vd NA 0.8511 L/kg 1compartment NA NA Human Human +DTXSID2043874 Vd NA 1.197 L/kg 1compartment NA NA Human Human DTXSID2043874 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2043874 TK.Half.Life NA 0.5859 hours 1compartment NA NA Human Human -DTXSID2043874 Css NA 0.02276 mg/L 3compartmentss NA 50% Human Human -DTXSID2043874 Css NA 0.2873 mg/L 3compartmentss NA 95% Human Human -DTXSID2043874 Css NA 0.01923 mg/L PBTK NA 50% Human Human -DTXSID2043874 Css NA 0.2176 mg/L PBTK NA 95% Human Human +DTXSID2043874 TK.Half.Life NA 0.7909 hours 1compartment NA NA Human Human +DTXSID2043874 Css NA 0.01918 mg/L 3compartmentss NA 50% Human Human +DTXSID2043874 Css NA 0.2336 mg/L 3compartmentss NA 95% Human Human +DTXSID2043874 Css NA 0.01732 mg/L PBTK NA 50% Human Human +DTXSID2043874 Css NA 0.1868 mg/L PBTK NA 95% Human Human DTXSID2043874 Clint NA 22.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2043874 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2043874 Vd NA 0.8786 L/kg 1compartment NA NA Rat Human +DTXSID2043874 Vd NA 1.155 L/kg 1compartment NA NA Rat Human DTXSID2043874 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2043874 TK.Half.Life NA 0.2874 hours 1compartment NA NA Rat Human -DTXSID2043874 Css NA 0.01135 mg/L 3compartmentss NA 50% Rat Human -DTXSID2043874 Css NA 0.1091 mg/L 3compartmentss NA 95% Rat Human -DTXSID2043874 Css NA 0.009521 mg/L PBTK NA 50% Rat Human -DTXSID2043874 Css NA 0.0786 mg/L PBTK NA 95% Rat Human -DTXSID2043903 Clint NA 1.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2043903 Fup NA 0.1491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2043903 Vd NA 1.122 L/kg 1compartment NA NA Human Human -DTXSID2043903 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2043903 TK.Half.Life NA 18.26 hours 1compartment NA NA Human Human -DTXSID2043903 Css NA 2.205 mg/L 3compartmentss NA 50% Human Human -DTXSID2043903 Css NA 11.18 mg/L 3compartmentss NA 95% Human Human -DTXSID2043903 Css NA 1.489 mg/L PBTK NA 50% Human Human -DTXSID2043903 Css NA 6.956 mg/L PBTK NA 95% Human Human -DTXSID2043903 Clint NA 1.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2043903 Fup NA 0.1491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2043903 Vd NA 0.8921 L/kg 1compartment NA NA Rat Human +DTXSID2043874 TK.Half.Life NA 0.3623 hours 1compartment NA NA Rat Human +DTXSID2043874 Css NA 0.002214 mg/L 3compartmentss NA 50% Rat Human +DTXSID2043874 Css NA 0.0233 mg/L 3compartmentss NA 95% Rat Human +DTXSID2043874 Css NA 0.002086 mg/L PBTK NA 50% Rat Human +DTXSID2043874 Css NA 0.0176 mg/L PBTK NA 95% Rat Human +DTXSID2043903 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2043903 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2043903 Vd NA 0.9112 L/kg 1compartment NA NA Human Human +DTXSID2043903 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2043903 TK.Half.Life NA 2.378 hours 1compartment NA NA Human Human +DTXSID2043903 Css NA 0.2823 mg/L 3compartmentss NA 50% Human Human +DTXSID2043903 Css NA 2.286 mg/L 3compartmentss NA 95% Human Human +DTXSID2043903 Css NA 0.1805 mg/L PBTK NA 50% Human Human +DTXSID2043903 Css NA 1.399 mg/L PBTK NA 95% Human Human +DTXSID2043903 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2043903 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2043903 Vd NA 0.7225 L/kg 1compartment NA NA Rat Human DTXSID2043903 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2043903 TK.Half.Life NA 6.723 hours 1compartment NA NA Rat Human -DTXSID2043903 Css NA 0.9432 mg/L 3compartmentss NA 50% Rat Human -DTXSID2043903 Css NA 3.667 mg/L 3compartmentss NA 95% Rat Human -DTXSID2043903 Css NA 0.6028 mg/L PBTK NA 50% Rat Human -DTXSID2043903 Css NA 2.099 mg/L PBTK NA 95% Rat Human -DTXSID2043909 Clint NA 10.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2043909 Fup NA 0.1853 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2043909 Vd NA 2.717 L/kg 1compartment NA NA Human Human +DTXSID2043903 TK.Half.Life NA 1.061 hours 1compartment NA NA Rat Human +DTXSID2043903 Css NA 0.03639 mg/L 3compartmentss NA 50% Rat Human +DTXSID2043903 Css NA 0.2381 mg/L 3compartmentss NA 95% Rat Human +DTXSID2043903 Css NA 0.02284 mg/L PBTK NA 50% Rat Human +DTXSID2043903 Css NA 0.1418 mg/L PBTK NA 95% Rat Human +DTXSID2043909 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2043909 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2043909 Vd NA 1.338 L/kg 1compartment NA NA Human Human DTXSID2043909 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2043909 TK.Half.Life NA 6.102 hours 1compartment NA NA Human Human -DTXSID2043909 Css NA 0.1638 mg/L 3compartmentss NA 50% Human Human -DTXSID2043909 Css NA 1.133 mg/L 3compartmentss NA 95% Human Human -DTXSID2043909 Css NA 0.1563 mg/L PBTK NA 50% Human Human -DTXSID2043909 Css NA 0.9065 mg/L PBTK NA 95% Human Human -DTXSID2043909 Clint NA 10.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2043909 Fup NA 0.1853 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2043909 Vd NA 2.677 L/kg 1compartment NA NA Rat Human +DTXSID2043909 TK.Half.Life NA 3.142 hours 1compartment NA NA Human Human +DTXSID2043909 Css NA 0.1866 mg/L 3compartmentss NA 50% Human Human +DTXSID2043909 Css NA 1.224 mg/L 3compartmentss NA 95% Human Human +DTXSID2043909 Css NA 0.151 mg/L PBTK NA 50% Human Human +DTXSID2043909 Css NA 0.8674 mg/L PBTK NA 95% Human Human +DTXSID2043909 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2043909 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2043909 Vd NA 1.344 L/kg 1compartment NA NA Rat Human DTXSID2043909 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2043909 TK.Half.Life NA 3.455 hours 1compartment NA NA Rat Human -DTXSID2043909 Css NA 0.08428 mg/L 3compartmentss NA 50% Rat Human -DTXSID2043909 Css NA 0.4646 mg/L 3compartmentss NA 95% Rat Human -DTXSID2043909 Css NA 0.07888 mg/L PBTK NA 50% Rat Human -DTXSID2043909 Css NA 0.3513 mg/L PBTK NA 95% Rat Human -DTXSID2044000 Clint NA 7.708 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044000 Fup NA 0.0742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044000 Vd NA 2.982 L/kg 1compartment NA NA Human Human +DTXSID2043909 TK.Half.Life NA 1.819 hours 1compartment NA NA Rat Human +DTXSID2043909 Css NA 0.02156 mg/L 3compartmentss NA 50% Rat Human +DTXSID2043909 Css NA 0.1078 mg/L 3compartmentss NA 95% Rat Human +DTXSID2043909 Css NA 0.01761 mg/L PBTK NA 50% Rat Human +DTXSID2043909 Css NA 0.07301 mg/L PBTK NA 95% Rat Human +DTXSID2043951 Clint 9.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2043951 Fup 0.046 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2043951 Vd NA 0.306 L/kg 1compartment NA NA Human Human +DTXSID2043951 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2043951 TK.Half.Life NA 2.876 hours 1compartment NA NA Human Human +DTXSID2043951 Css NA 1.493 mg/L 3compartmentss NA 50% Human Human +DTXSID2043951 Css NA 10.39 mg/L 3compartmentss NA 95% Human Human +DTXSID2043951 Css NA 0.8984 mg/L PBTK NA 50% Human Human +DTXSID2043951 Css NA 6.187 mg/L PBTK NA 95% Human Human +DTXSID2043951 Clint 9.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2043951 Fup 0.046 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2043951 Vd NA 0.2746 L/kg 1compartment NA NA Rat Human +DTXSID2043951 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2043951 TK.Half.Life NA 1.634 hours 1compartment NA NA Rat Human +DTXSID2043951 Css NA 0.169 mg/L 3compartmentss NA 50% Rat Human +DTXSID2043951 Css NA 0.9296 mg/L 3compartmentss NA 95% Rat Human +DTXSID2043951 Css NA 0.0984 mg/L PBTK NA 50% Rat Human +DTXSID2043951 Css NA 0.5281 mg/L PBTK NA 95% Rat Human +DTXSID2044000 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044000 Fup 0.0702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044000 Vd NA 2.907 L/kg 1compartment NA NA Human Human DTXSID2044000 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044000 TK.Half.Life NA 5.839 hours 1compartment NA NA Human Human -DTXSID2044000 Css NA 0.1608 mg/L 3compartmentss NA 50% Human Human -DTXSID2044000 Css NA 1.524 mg/L 3compartmentss NA 95% Human Human -DTXSID2044000 Css NA 0.1562 mg/L PBTK NA 50% Human Human -DTXSID2044000 Css NA 1.194 mg/L PBTK NA 95% Human Human -DTXSID2044000 Clint NA 7.708 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044000 Fup NA 0.0742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044000 Vd NA 2.895 L/kg 1compartment NA NA Rat Human +DTXSID2044000 TK.Half.Life NA 3.099 hours 1compartment NA NA Human Human +DTXSID2044000 Css NA 0.05756 mg/L 3compartmentss NA 50% Human Human +DTXSID2044000 Css NA 0.5282 mg/L 3compartmentss NA 95% Human Human +DTXSID2044000 Css NA 0.05387 mg/L PBTK NA 50% Human Human +DTXSID2044000 Css NA 0.4113 mg/L PBTK NA 95% Human Human +DTXSID2044000 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044000 Fup 0.0702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044000 Vd NA 2.818 L/kg 1compartment NA NA Rat Human DTXSID2044000 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044000 TK.Half.Life NA 3.282 hours 1compartment NA NA Rat Human -DTXSID2044000 Css NA 0.08857 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044000 Css NA 0.6713 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044000 Css NA 0.08364 mg/L PBTK NA 50% Rat Human -DTXSID2044000 Css NA 0.5014 mg/L PBTK NA 95% Rat Human -DTXSID2044002 Clint NA 104.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2044000 TK.Half.Life NA 1.612 hours 1compartment NA NA Rat Human +DTXSID2044000 Css NA 0.007377 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044000 Css NA 0.05619 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044000 Css NA 0.007046 mg/L PBTK NA 50% Rat Human +DTXSID2044000 Css NA 0.04415 mg/L PBTK NA 95% Rat Human +DTXSID2044002 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2044002 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2044002 Vd NA 1.302 L/kg 1compartment NA NA Human Human +DTXSID2044002 Vd NA 2.764 L/kg 1compartment NA NA Human Human DTXSID2044002 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044002 TK.Half.Life NA 1.201 hours 1compartment NA NA Human Human -DTXSID2044002 Css NA 0.02227 mg/L 3compartmentss NA 50% Human Human -DTXSID2044002 Css NA 0.1662 mg/L 3compartmentss NA 95% Human Human -DTXSID2044002 Css NA 0.01666 mg/L PBTK NA 50% Human Human -DTXSID2044002 Css NA 0.1133 mg/L PBTK NA 95% Human Human -DTXSID2044002 Clint NA 104.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2044002 TK.Half.Life NA 6.829 hours 1compartment NA NA Human Human +DTXSID2044002 Css NA 0.195 mg/L 3compartmentss NA 50% Human Human +DTXSID2044002 Css NA 1.255 mg/L 3compartmentss NA 95% Human Human +DTXSID2044002 Css NA 0.1516 mg/L PBTK NA 50% Human Human +DTXSID2044002 Css NA 0.9075 mg/L PBTK NA 95% Human Human +DTXSID2044002 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2044002 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2044002 Vd NA 1.195 L/kg 1compartment NA NA Rat Human +DTXSID2044002 Vd NA 2.224 L/kg 1compartment NA NA Rat Human DTXSID2044002 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044002 TK.Half.Life NA 0.5271 hours 1compartment NA NA Rat Human -DTXSID2044002 Css NA 0.01241 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044002 Css NA 0.07457 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044002 Css NA 0.008917 mg/L PBTK NA 50% Rat Human -DTXSID2044002 Css NA 0.05003 mg/L PBTK NA 95% Rat Human -DTXSID2044131 Clint NA 4.667 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044131 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044131 Vd NA 0.3259 L/kg 1compartment NA NA Human Human +DTXSID2044002 TK.Half.Life NA 2.081 hours 1compartment NA NA Rat Human +DTXSID2044002 Css NA 0.02452 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044002 Css NA 0.1241 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044002 Css NA 0.01897 mg/L PBTK NA 50% Rat Human +DTXSID2044002 Css NA 0.09091 mg/L PBTK NA 95% Rat Human +DTXSID2044131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044131 Fup 0.0754 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044131 Vd NA 0.453 L/kg 1compartment NA NA Human Human DTXSID2044131 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044131 TK.Half.Life NA 6.876 hours 1compartment NA NA Human Human -DTXSID2044131 Css NA 3.742 mg/L 3compartmentss NA 50% Human Human -DTXSID2044131 Css NA 23.21 mg/L 3compartmentss NA 95% Human Human -DTXSID2044131 Css NA 2.228 mg/L PBTK NA 50% Human Human -DTXSID2044131 Css NA 13.59 mg/L PBTK NA 95% Human Human -DTXSID2044131 Clint NA 4.667 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044131 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044131 Vd NA 0.2855 L/kg 1compartment NA NA Rat Human +DTXSID2044131 TK.Half.Life NA 1.425 hours 1compartment NA NA Human Human +DTXSID2044131 Css NA 0.3919 mg/L 3compartmentss NA 50% Human Human +DTXSID2044131 Css NA 2.945 mg/L 3compartmentss NA 95% Human Human +DTXSID2044131 Css NA 0.2404 mg/L PBTK NA 50% Human Human +DTXSID2044131 Css NA 1.795 mg/L PBTK NA 95% Human Human +DTXSID2044131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044131 Fup 0.0754 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044131 Vd NA 0.3924 L/kg 1compartment NA NA Rat Human DTXSID2044131 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044131 TK.Half.Life NA 3.703 hours 1compartment NA NA Rat Human -DTXSID2044131 Css NA 1.966 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044131 Css NA 8.971 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044131 Css NA 1.093 mg/L PBTK NA 50% Rat Human -DTXSID2044131 Css NA 4.887 mg/L PBTK NA 95% Rat Human -DTXSID2044137 Clint NA 24.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044137 Fup NA 0.2401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044137 Vd NA 3.037 L/kg 1compartment NA NA Human Human +DTXSID2044131 TK.Half.Life NA 0.7436 hours 1compartment NA NA Rat Human +DTXSID2044131 Css NA 0.05098 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044131 Css NA 0.2983 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044131 Css NA 0.0305 mg/L PBTK NA 50% Rat Human +DTXSID2044131 Css NA 0.1728 mg/L PBTK NA 95% Rat Human +DTXSID2044137 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044137 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044137 Vd NA 3.333 L/kg 1compartment NA NA Human Human DTXSID2044137 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044137 TK.Half.Life NA 3.184 hours 1compartment NA NA Human Human -DTXSID2044137 Css NA 0.04746 mg/L 3compartmentss NA 50% Human Human -DTXSID2044137 Css NA 0.3714 mg/L 3compartmentss NA 95% Human Human -DTXSID2044137 Css NA 0.05021 mg/L PBTK NA 50% Human Human -DTXSID2044137 Css NA 0.3284 mg/L PBTK NA 95% Human Human -DTXSID2044137 Clint NA 24.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044137 Fup NA 0.2401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044137 Vd NA 3.068 L/kg 1compartment NA NA Rat Human +DTXSID2044137 TK.Half.Life NA 7.365 hours 1compartment NA NA Human Human +DTXSID2044137 Css NA 0.136 mg/L 3compartmentss NA 50% Human Human +DTXSID2044137 Css NA 0.9874 mg/L 3compartmentss NA 95% Human Human +DTXSID2044137 Css NA 0.1546 mg/L PBTK NA 50% Human Human +DTXSID2044137 Css NA 0.8701 mg/L PBTK NA 95% Human Human +DTXSID2044137 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044137 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044137 Vd NA 3.375 L/kg 1compartment NA NA Rat Human DTXSID2044137 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044137 TK.Half.Life NA 1.793 hours 1compartment NA NA Rat Human -DTXSID2044137 Css NA 0.02466 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044137 Css NA 0.1595 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044137 Css NA 0.02656 mg/L PBTK NA 50% Rat Human -DTXSID2044137 Css NA 0.1363 mg/L PBTK NA 95% Rat Human -DTXSID2044210 Clint NA 0.8242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044210 Fup NA 0.803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044210 Vd NA 0.9995 L/kg 1compartment NA NA Human Human +DTXSID2044137 TK.Half.Life NA 4.401 hours 1compartment NA NA Rat Human +DTXSID2044137 Css NA 0.01544 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044137 Css NA 0.08824 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044137 Css NA 0.01809 mg/L PBTK NA 50% Rat Human +DTXSID2044137 Css NA 0.07607 mg/L PBTK NA 95% Rat Human +DTXSID2044210 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044210 Fup 0.653 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044210 Vd NA 0.9179 L/kg 1compartment NA NA Human Human DTXSID2044210 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044210 TK.Half.Life NA 3.662 hours 1compartment NA NA Human Human -DTXSID2044210 Css NA 0.3972 mg/L 3compartmentss NA 50% Human Human -DTXSID2044210 Css NA 2.671 mg/L 3compartmentss NA 95% Human Human -DTXSID2044210 Css NA 0.3454 mg/L PBTK NA 50% Human Human -DTXSID2044210 Css NA 1.775 mg/L PBTK NA 95% Human Human -DTXSID2044210 Clint NA 0.8242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044210 Fup NA 0.803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044210 Vd NA 0.9739 L/kg 1compartment NA NA Rat Human +DTXSID2044210 TK.Half.Life NA 9.256 hours 1compartment NA NA Human Human +DTXSID2044210 Css NA 0.95 mg/L 3compartmentss NA 50% Human Human +DTXSID2044210 Css NA 6.238 mg/L 3compartmentss NA 95% Human Human +DTXSID2044210 Css NA 0.8051 mg/L PBTK NA 50% Human Human +DTXSID2044210 Css NA 4.028 mg/L PBTK NA 95% Human Human +DTXSID2044210 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044210 Fup 0.653 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044210 Vd NA 0.8962 L/kg 1compartment NA NA Rat Human DTXSID2044210 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044210 TK.Half.Life NA 1.652 hours 1compartment NA NA Rat Human -DTXSID2044210 Css NA 0.1458 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044210 Css NA 0.9558 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044210 Css NA 0.1246 mg/L PBTK NA 50% Rat Human -DTXSID2044210 Css NA 0.5859 mg/L PBTK NA 95% Rat Human -DTXSID2044214 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044214 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044214 Vd NA 1.956 L/kg 1compartment NA NA Human Human -DTXSID2044214 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2044214 TK.Half.Life NA 16.69 hours 1compartment NA NA Human Human -DTXSID2044214 Css NA 0.7635 mg/L 3compartmentss NA 50% Human Human -DTXSID2044214 Css NA 5.226 mg/L 3compartmentss NA 95% Human Human -DTXSID2044214 Css NA 0.768 mg/L PBTK NA 50% Human Human -DTXSID2044214 Css NA 3.657 mg/L PBTK NA 95% Human Human -DTXSID2044214 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044214 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044214 Vd NA 1.695 L/kg 1compartment NA NA Rat Human +DTXSID2044210 TK.Half.Life NA 3.039 hours 1compartment NA NA Rat Human +DTXSID2044210 Css NA 0.02419 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044210 Css NA 0.2007 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044210 Css NA 0.02001 mg/L PBTK NA 50% Rat Human +DTXSID2044210 Css NA 0.1276 mg/L PBTK NA 95% Rat Human +DTXSID2044214 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044214 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044214 Vd NA 0.9256 L/kg 1compartment NA NA Human Human +DTXSID2044214 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2044214 TK.Half.Life NA 2.668 hours 1compartment NA NA Human Human +DTXSID2044214 Css NA 0.262 mg/L 3compartmentss NA 50% Human Human +DTXSID2044214 Css NA 1.644 mg/L 3compartmentss NA 95% Human Human +DTXSID2044214 Css NA 0.1898 mg/L PBTK NA 50% Human Human +DTXSID2044214 Css NA 1.088 mg/L PBTK NA 95% Human Human +DTXSID2044214 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044214 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044214 Vd NA 0.7947 L/kg 1compartment NA NA Rat Human DTXSID2044214 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044214 TK.Half.Life NA 4.021 hours 1compartment NA NA Rat Human -DTXSID2044214 Css NA 0.1966 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044214 Css NA 1.237 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044214 Css NA 0.195 mg/L PBTK NA 50% Rat Human -DTXSID2044214 Css NA 0.8038 mg/L PBTK NA 95% Rat Human -DTXSID2044218 Clint NA 42.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044218 Fup NA 0.0624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044218 Vd NA 3.082 L/kg 1compartment NA NA Human Human -DTXSID2044218 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2044218 TK.Half.Life NA 27.93 hours 1compartment NA NA Human Human -DTXSID2044218 Css NA 1.054 mg/L 3compartmentss NA 50% Human Human -DTXSID2044218 Css NA 6.71 mg/L 3compartmentss NA 95% Human Human -DTXSID2044218 Css NA 0.7298 mg/L PBTK NA 50% Human Human -DTXSID2044218 Css NA 4.44 mg/L PBTK NA 95% Human Human -DTXSID2044218 Clint NA 42.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044218 Fup NA 0.0624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044218 Vd NA 2.315 L/kg 1compartment NA NA Rat Human -DTXSID2044218 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2044218 TK.Half.Life NA 4.368 hours 1compartment NA NA Rat Human -DTXSID2044218 Css NA 0.5819 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044218 Css NA 3.221 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044218 Css NA 0.3887 mg/L PBTK NA 50% Rat Human -DTXSID2044218 Css NA 2.059 mg/L PBTK NA 95% Rat Human -DTXSID2044266 Clint NA 45.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044266 Fup NA 0.1342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044266 Vd NA 1.971 L/kg 1compartment NA NA Human Human +DTXSID2044214 TK.Half.Life NA 1.273 hours 1compartment NA NA Rat Human +DTXSID2044214 Css NA 0.03071 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044214 Css NA 0.1388 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044214 Css NA 0.02202 mg/L PBTK NA 50% Rat Human +DTXSID2044214 Css NA 0.08929 mg/L PBTK NA 95% Rat Human +DTXSID2044218 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044218 Fup 0.0924 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044218 Vd NA 2.649 L/kg 1compartment NA NA Human Human +DTXSID2044218 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2044218 TK.Half.Life NA 14.41 hours 1compartment NA NA Human Human +DTXSID2044218 Css NA 0.6166 mg/L 3compartmentss NA 50% Human Human +DTXSID2044218 Css NA 3.878 mg/L 3compartmentss NA 95% Human Human +DTXSID2044218 Css NA 0.4286 mg/L PBTK NA 50% Human Human +DTXSID2044218 Css NA 2.606 mg/L PBTK NA 95% Human Human +DTXSID2044218 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044218 Fup 0.0924 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044218 Vd NA 1.991 L/kg 1compartment NA NA Rat Human +DTXSID2044218 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2044218 TK.Half.Life NA 3.376 hours 1compartment NA NA Rat Human +DTXSID2044218 Css NA 0.0786 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044218 Css NA 0.4239 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044218 Css NA 0.05434 mg/L PBTK NA 50% Rat Human +DTXSID2044218 Css NA 0.2856 mg/L PBTK NA 95% Rat Human +DTXSID2044266 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044266 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044266 Vd NA 1.796 L/kg 1compartment NA NA Human Human DTXSID2044266 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044266 TK.Half.Life NA 1.728 hours 1compartment NA NA Human Human -DTXSID2044266 Css NA 0.03542 mg/L 3compartmentss NA 50% Human Human -DTXSID2044266 Css NA 0.3702 mg/L 3compartmentss NA 95% Human Human -DTXSID2044266 Css NA 0.03216 mg/L PBTK NA 50% Human Human -DTXSID2044266 Css NA 0.2779 mg/L PBTK NA 95% Human Human -DTXSID2044266 Clint NA 45.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044266 Fup NA 0.1342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044266 Vd NA 1.928 L/kg 1compartment NA NA Rat Human +DTXSID2044266 TK.Half.Life NA 2.389 hours 1compartment NA NA Human Human +DTXSID2044266 Css NA 0.08372 mg/L 3compartmentss NA 50% Human Human +DTXSID2044266 Css NA 0.8259 mg/L 3compartmentss NA 95% Human Human +DTXSID2044266 Css NA 0.07297 mg/L PBTK NA 50% Human Human +DTXSID2044266 Css NA 0.5973 mg/L PBTK NA 95% Human Human +DTXSID2044266 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044266 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044266 Vd NA 1.755 L/kg 1compartment NA NA Rat Human DTXSID2044266 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044266 TK.Half.Life NA 0.8868 hours 1compartment NA NA Rat Human -DTXSID2044266 Css NA 0.01965 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044266 Css NA 0.1547 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044266 Css NA 0.01741 mg/L PBTK NA 50% Rat Human -DTXSID2044266 Css NA 0.111 mg/L PBTK NA 95% Rat Human -DTXSID2044268 Clint NA 19.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044268 Fup NA 0.0918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044268 Vd NA 0.5175 L/kg 1compartment NA NA Human Human +DTXSID2044266 TK.Half.Life NA 1.337 hours 1compartment NA NA Rat Human +DTXSID2044266 Css NA 0.01078 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044266 Css NA 0.08602 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044266 Css NA 0.009424 mg/L PBTK NA 50% Rat Human +DTXSID2044266 Css NA 0.06048 mg/L PBTK NA 95% Rat Human +DTXSID2044268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044268 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044268 Vd NA 0.3836 L/kg 1compartment NA NA Human Human DTXSID2044268 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044268 TK.Half.Life NA 1.539 hours 1compartment NA NA Human Human -DTXSID2044268 Css NA 0.3644 mg/L 3compartmentss NA 50% Human Human -DTXSID2044268 Css NA 2.864 mg/L 3compartmentss NA 95% Human Human -DTXSID2044268 Css NA 0.2265 mg/L PBTK NA 50% Human Human -DTXSID2044268 Css NA 1.738 mg/L PBTK NA 95% Human Human -DTXSID2044268 Clint NA 19.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044268 Fup NA 0.0918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044268 Vd NA 0.4405 L/kg 1compartment NA NA Rat Human +DTXSID2044268 TK.Half.Life NA 0.8106 hours 1compartment NA NA Human Human +DTXSID2044268 Css NA 0.1959 mg/L 3compartmentss NA 50% Human Human +DTXSID2044268 Css NA 1.686 mg/L 3compartmentss NA 95% Human Human +DTXSID2044268 Css NA 0.128 mg/L PBTK NA 50% Human Human +DTXSID2044268 Css NA 1.047 mg/L PBTK NA 95% Human Human +DTXSID2044268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044268 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044268 Vd NA 0.3782 L/kg 1compartment NA NA Rat Human DTXSID2044268 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044268 TK.Half.Life NA 0.7787 hours 1compartment NA NA Rat Human -DTXSID2044268 Css NA 0.2022 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044268 Css NA 1.257 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044268 Css NA 0.1182 mg/L PBTK NA 50% Rat Human -DTXSID2044268 Css NA 0.7151 mg/L PBTK NA 95% Rat Human -DTXSID2044347 Clint NA 37.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044347 Fup NA 0.4819 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044347 Vd NA 1.431 L/kg 1compartment NA NA Human Human +DTXSID2044268 TK.Half.Life NA 0.4633 hours 1compartment NA NA Rat Human +DTXSID2044268 Css NA 0.0258 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044268 Css NA 0.1607 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044268 Css NA 0.01638 mg/L PBTK NA 50% Rat Human +DTXSID2044268 Css NA 0.09594 mg/L PBTK NA 95% Rat Human +DTXSID2044347 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044347 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044347 Vd NA 1.048 L/kg 1compartment NA NA Human Human DTXSID2044347 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044347 TK.Half.Life NA 1.241 hours 1compartment NA NA Human Human -DTXSID2044347 Css NA 0.02615 mg/L 3compartmentss NA 50% Human Human -DTXSID2044347 Css NA 0.2358 mg/L 3compartmentss NA 95% Human Human -DTXSID2044347 Css NA 0.02158 mg/L PBTK NA 50% Human Human -DTXSID2044347 Css NA 0.1668 mg/L PBTK NA 95% Human Human -DTXSID2044347 Clint NA 37.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044347 Fup NA 0.4819 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044347 Vd NA 1.215 L/kg 1compartment NA NA Rat Human +DTXSID2044347 TK.Half.Life NA 1.474 hours 1compartment NA NA Human Human +DTXSID2044347 Css NA 0.07883 mg/L 3compartmentss NA 50% Human Human +DTXSID2044347 Css NA 0.5775 mg/L 3compartmentss NA 95% Human Human +DTXSID2044347 Css NA 0.05726 mg/L PBTK NA 50% Human Human +DTXSID2044347 Css NA 0.3928 mg/L PBTK NA 95% Human Human +DTXSID2044347 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044347 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044347 Vd NA 0.8827 L/kg 1compartment NA NA Rat Human DTXSID2044347 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044347 TK.Half.Life NA 0.4951 hours 1compartment NA NA Rat Human -DTXSID2044347 Css NA 0.01417 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044347 Css NA 0.09681 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044347 Css NA 0.01129 mg/L PBTK NA 50% Rat Human -DTXSID2044347 Css NA 0.0661 mg/L PBTK NA 95% Rat Human -DTXSID2044391 Clint NA 7.602 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044391 Fup NA 0.2275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044391 Vd NA 2.3 L/kg 1compartment NA NA Human Human +DTXSID2044347 TK.Half.Life NA 0.6454 hours 1compartment NA NA Rat Human +DTXSID2044347 Css NA 0.009913 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044347 Css NA 0.05346 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044347 Css NA 0.007218 mg/L PBTK NA 50% Rat Human +DTXSID2044347 Css NA 0.03636 mg/L PBTK NA 95% Rat Human +DTXSID2044391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044391 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044391 Vd NA 1.732 L/kg 1compartment NA NA Human Human DTXSID2044391 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044391 TK.Half.Life NA 10.48 hours 1compartment NA NA Human Human -DTXSID2044391 Css NA 0.4659 mg/L 3compartmentss NA 50% Human Human -DTXSID2044391 Css NA 2.669 mg/L 3compartmentss NA 95% Human Human -DTXSID2044391 Css NA 0.3427 mg/L PBTK NA 50% Human Human -DTXSID2044391 Css NA 1.838 mg/L PBTK NA 95% Human Human -DTXSID2044391 Clint NA 7.602 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044391 Fup NA 0.2275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044391 Vd NA 1.766 L/kg 1compartment NA NA Rat Human +DTXSID2044391 TK.Half.Life NA 5.196 hours 1compartment NA NA Human Human +DTXSID2044391 Css NA 0.3276 mg/L 3compartmentss NA 50% Human Human +DTXSID2044391 Css NA 2.364 mg/L 3compartmentss NA 95% Human Human +DTXSID2044391 Css NA 0.2193 mg/L PBTK NA 50% Human Human +DTXSID2044391 Css NA 1.508 mg/L PBTK NA 95% Human Human +DTXSID2044391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044391 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044391 Vd NA 1.319 L/kg 1compartment NA NA Rat Human DTXSID2044391 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044391 TK.Half.Life NA 3.063 hours 1compartment NA NA Rat Human -DTXSID2044391 Css NA 0.2454 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044391 Css NA 0.9886 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044391 Css NA 0.174 mg/L PBTK NA 50% Rat Human -DTXSID2044391 Css NA 0.646 mg/L PBTK NA 95% Rat Human -DTXSID2044393 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044393 Fup NA 0.9747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044393 Vd NA 0.5698 L/kg 1compartment NA NA Human Human +DTXSID2044391 TK.Half.Life NA 1.887 hours 1compartment NA NA Rat Human +DTXSID2044391 Css NA 0.04211 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044391 Css NA 0.2399 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044391 Css NA 0.02756 mg/L PBTK NA 50% Rat Human +DTXSID2044391 Css NA 0.1519 mg/L PBTK NA 95% Rat Human +DTXSID2044393 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044393 Fup 0.601 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044393 Vd NA 0.4308 L/kg 1compartment NA NA Human Human DTXSID2044393 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044393 TK.Half.Life NA 3.784 hours 1compartment NA NA Human Human -DTXSID2044393 Css NA 0.9614 mg/L 3compartmentss NA 50% Human Human -DTXSID2044393 Css NA 5.351 mg/L 3compartmentss NA 95% Human Human -DTXSID2044393 Css NA 0.7376 mg/L PBTK NA 50% Human Human -DTXSID2044393 Css NA 3.362 mg/L PBTK NA 95% Human Human -DTXSID2044393 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044393 Fup NA 0.9747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044393 Vd NA 0.5932 L/kg 1compartment NA NA Rat Human +DTXSID2044393 TK.Half.Life NA 4.64 hours 1compartment NA NA Human Human +DTXSID2044393 Css NA 1.162 mg/L 3compartmentss NA 50% Human Human +DTXSID2044393 Css NA 7.487 mg/L 3compartmentss NA 95% Human Human +DTXSID2044393 Css NA 0.837 mg/L PBTK NA 50% Human Human +DTXSID2044393 Css NA 4.565 mg/L PBTK NA 95% Human Human +DTXSID2044393 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044393 Fup 0.601 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044393 Vd NA 0.4482 L/kg 1compartment NA NA Rat Human DTXSID2044393 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044393 TK.Half.Life NA 1.342 hours 1compartment NA NA Rat Human -DTXSID2044393 Css NA 0.2454 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044393 Css NA 1.228 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044393 Css NA 0.1819 mg/L PBTK NA 50% Rat Human -DTXSID2044393 Css NA 0.7251 mg/L PBTK NA 95% Rat Human +DTXSID2044393 TK.Half.Life NA 1.644 hours 1compartment NA NA Rat Human +DTXSID2044393 Css NA 0.02246 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044393 Css NA 0.1796 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044393 Css NA 0.01545 mg/L PBTK NA 50% Rat Human +DTXSID2044393 Css NA 0.1089 mg/L PBTK NA 95% Rat Human DTXSID2044397 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2044397 Fup NA 0.6086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044397 Vd NA 0.6914 L/kg 1compartment NA NA Human Human +DTXSID2044397 Vd NA 0.6774 L/kg 1compartment NA NA Human Human DTXSID2044397 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044397 TK.Half.Life NA 7.35 hours 1compartment NA NA Human Human -DTXSID2044397 Css NA 1.195 mg/L 3compartmentss NA 50% Human Human -DTXSID2044397 Css NA 8.051 mg/L 3compartmentss NA 95% Human Human -DTXSID2044397 Css NA 0.9736 mg/L PBTK NA 50% Human Human -DTXSID2044397 Css NA 5.12 mg/L PBTK NA 95% Human Human +DTXSID2044397 TK.Half.Life NA 7.202 hours 1compartment NA NA Human Human +DTXSID2044397 Css NA 1.016 mg/L 3compartmentss NA 50% Human Human +DTXSID2044397 Css NA 6.986 mg/L 3compartmentss NA 95% Human Human +DTXSID2044397 Css NA 0.8239 mg/L PBTK NA 50% Human Human +DTXSID2044397 Css NA 4.402 mg/L PBTK NA 95% Human Human DTXSID2044397 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2044397 Fup NA 0.6086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044397 Vd NA 0.7096 L/kg 1compartment NA NA Rat Human +DTXSID2044397 Vd NA 0.6961 L/kg 1compartment NA NA Rat Human DTXSID2044397 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044397 TK.Half.Life NA 2.571 hours 1compartment NA NA Rat Human -DTXSID2044397 Css NA 0.3114 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044397 Css NA 2.054 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044397 Css NA 0.2442 mg/L PBTK NA 50% Rat Human -DTXSID2044397 Css NA 1.21 mg/L PBTK NA 95% Rat Human -DTXSID2044399 Clint NA 0.1147 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044399 Fup NA 0.3265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044399 Vd NA 0.4957 L/kg 1compartment NA NA Human Human +DTXSID2044397 TK.Half.Life NA 2.522 hours 1compartment NA NA Rat Human +DTXSID2044397 Css NA 0.01978 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044397 Css NA 0.1679 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044397 Css NA 0.01548 mg/L PBTK NA 50% Rat Human +DTXSID2044397 Css NA 0.1065 mg/L PBTK NA 95% Rat Human +DTXSID2044399 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044399 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044399 Vd NA 0.5299 L/kg 1compartment NA NA Human Human DTXSID2044399 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044399 TK.Half.Life NA 8.214 hours 1compartment NA NA Human Human -DTXSID2044399 Css NA 1.845 mg/L 3compartmentss NA 50% Human Human -DTXSID2044399 Css NA 7.635 mg/L 3compartmentss NA 95% Human Human -DTXSID2044399 Css NA 1.328 mg/L PBTK NA 50% Human Human -DTXSID2044399 Css NA 4.825 mg/L PBTK NA 95% Human Human -DTXSID2044399 Clint NA 0.1147 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044399 Fup NA 0.3265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044399 Vd NA 0.5056 L/kg 1compartment NA NA Rat Human +DTXSID2044399 TK.Half.Life NA 9.292 hours 1compartment NA NA Human Human +DTXSID2044399 Css NA 1.899 mg/L 3compartmentss NA 50% Human Human +DTXSID2044399 Css NA 7.982 mg/L 3compartmentss NA 95% Human Human +DTXSID2044399 Css NA 1.398 mg/L PBTK NA 50% Human Human +DTXSID2044399 Css NA 5.086 mg/L PBTK NA 95% Human Human +DTXSID2044399 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044399 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044399 Vd NA 0.5409 L/kg 1compartment NA NA Rat Human DTXSID2044399 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044399 TK.Half.Life NA 3.118 hours 1compartment NA NA Rat Human -DTXSID2044399 Css NA 0.5704 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044399 Css NA 1.995 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044399 Css NA 0.3896 mg/L PBTK NA 50% Rat Human -DTXSID2044399 Css NA 1.175 mg/L PBTK NA 95% Rat Human +DTXSID2044399 TK.Half.Life NA 3.231 hours 1compartment NA NA Rat Human +DTXSID2044399 Css NA 0.1218 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044399 Css NA 0.4361 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044399 Css NA 0.08828 mg/L PBTK NA 50% Rat Human +DTXSID2044399 Css NA 0.2674 mg/L PBTK NA 95% Rat Human DTXSID2044420 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2044420 Fup 0.0878 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2044420 Vd NA 1.662 L/kg 1compartment NA NA Human Human -DTXSID2044420 Days.Css NA 39 Days PBTK NA NA Human Human -DTXSID2044420 TK.Half.Life NA 185.6 hours 1compartment NA NA Human Human -DTXSID2044420 Css NA 13.36 mg/L 3compartmentss NA 50% Human Human -DTXSID2044420 Css NA 42.39 mg/L 3compartmentss NA 95% Human Human -DTXSID2044420 Css NA 9.012 mg/L PBTK NA 50% Human Human -DTXSID2044420 Css NA 26.57 mg/L PBTK NA 95% Human Human +DTXSID2044420 Vd NA 2.757 L/kg 1compartment NA NA Human Human +DTXSID2044420 Days.Css NA 262 Days PBTK NA NA Human Human +DTXSID2044420 TK.Half.Life NA 1032 hours 1compartment NA NA Human Human +DTXSID2044420 Css NA 41.69 mg/L 3compartmentss NA 50% Human Human +DTXSID2044420 Css NA 119 mg/L 3compartmentss NA 95% Human Human +DTXSID2044420 Css NA 29.17 mg/L PBTK NA 50% Human Human +DTXSID2044420 Css NA 76.68 mg/L PBTK NA 95% Human Human DTXSID2044420 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2044420 Fup 0.0878 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2044420 Vd NA 1.259 L/kg 1compartment NA NA Rat Human -DTXSID2044420 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID2044420 TK.Half.Life NA 35.51 hours 1compartment NA NA Rat Human -DTXSID2044420 Css NA 3.688 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044420 Css NA 9.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044420 Css NA 2.354 mg/L PBTK NA 50% Rat Human -DTXSID2044420 Css NA 5.653 mg/L PBTK NA 95% Rat Human -DTXSID2044422 Clint NA 507.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044422 Fup NA 0.8082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044422 Vd NA 2.814 L/kg 1compartment NA NA Human Human -DTXSID2044422 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044422 TK.Half.Life NA 1.197 hours 1compartment NA NA Human Human -DTXSID2044422 Css NA 0.0009474 mg/L 3compartmentss NA 50% Human Human -DTXSID2044422 Css NA 0.01106 mg/L 3compartmentss NA 95% Human Human -DTXSID2044422 Css NA 0.001051 mg/L PBTK NA 50% Human Human -DTXSID2044422 Css NA 0.009351 mg/L PBTK NA 95% Human Human -DTXSID2044422 Clint NA 507.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044422 Fup NA 0.8082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044422 Vd NA 2.859 L/kg 1compartment NA NA Rat Human -DTXSID2044422 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044422 TK.Half.Life NA 0.532 hours 1compartment NA NA Rat Human -DTXSID2044422 Css NA 0.0004758 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044422 Css NA 0.00547 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044422 Css NA 0.000537 mg/L PBTK NA 50% Rat Human -DTXSID2044422 Css NA 0.004584 mg/L PBTK NA 95% Rat Human -DTXSID2044424 Clint NA 0.747 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044424 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044424 Vd NA 2.384 L/kg 1compartment NA NA Human Human -DTXSID2044424 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044424 TK.Half.Life NA 7.213 hours 1compartment NA NA Human Human -DTXSID2044424 Css NA 0.2927 mg/L 3compartmentss NA 50% Human Human -DTXSID2044424 Css NA 2.199 mg/L 3compartmentss NA 95% Human Human -DTXSID2044424 Css NA 0.316 mg/L PBTK NA 50% Human Human -DTXSID2044424 Css NA 1.639 mg/L PBTK NA 95% Human Human -DTXSID2044424 Clint NA 0.747 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044424 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044424 Vd NA 2.429 L/kg 1compartment NA NA Rat Human +DTXSID2044420 Vd NA 2.072 L/kg 1compartment NA NA Rat Human +DTXSID2044420 Days.Css NA 64 Days PBTK NA NA Rat Human +DTXSID2044420 TK.Half.Life NA 102.7 hours 1compartment NA NA Rat Human +DTXSID2044420 Css NA 2.638 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044420 Css NA 5.967 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044420 Css NA 1.824 mg/L PBTK NA 50% Rat Human +DTXSID2044420 Css NA 3.722 mg/L PBTK NA 95% Rat Human +DTXSID2044422 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044422 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044422 Vd NA 2.463 L/kg 1compartment NA NA Human Human +DTXSID2044422 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2044422 TK.Half.Life NA 29.98 hours 1compartment NA NA Human Human +DTXSID2044422 Css NA 0.972 mg/L 3compartmentss NA 50% Human Human +DTXSID2044422 Css NA 6.977 mg/L 3compartmentss NA 95% Human Human +DTXSID2044422 Css NA 1.04 mg/L PBTK NA 50% Human Human +DTXSID2044422 Css NA 4.945 mg/L PBTK NA 95% Human Human +DTXSID2044422 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044422 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044422 Vd NA 2.492 L/kg 1compartment NA NA Rat Human +DTXSID2044422 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2044422 TK.Half.Life NA 10.33 hours 1compartment NA NA Rat Human +DTXSID2044422 Css NA 0.0588 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044422 Css NA 0.3941 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044422 Css NA 0.06383 mg/L PBTK NA 50% Rat Human +DTXSID2044422 Css NA 0.2694 mg/L PBTK NA 95% Rat Human +DTXSID2044424 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044424 Fup 0.791 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044424 Vd NA 2.028 L/kg 1compartment NA NA Human Human +DTXSID2044424 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2044424 TK.Half.Life NA 16.59 hours 1compartment NA NA Human Human +DTXSID2044424 Css NA 0.7832 mg/L 3compartmentss NA 50% Human Human +DTXSID2044424 Css NA 5.697 mg/L 3compartmentss NA 95% Human Human +DTXSID2044424 Css NA 0.799 mg/L PBTK NA 50% Human Human +DTXSID2044424 Css NA 3.949 mg/L PBTK NA 95% Human Human +DTXSID2044424 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044424 Fup 0.791 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044424 Vd NA 2.061 L/kg 1compartment NA NA Rat Human DTXSID2044424 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044424 TK.Half.Life NA 3.413 hours 1compartment NA NA Rat Human -DTXSID2044424 Css NA 0.1013 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044424 Css NA 0.7635 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044424 Css NA 0.1103 mg/L PBTK NA 50% Rat Human -DTXSID2044424 Css NA 0.5019 mg/L PBTK NA 95% Rat Human -DTXSID2044428 Clint NA 46.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044428 Fup NA 0.3292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044428 Vd NA 1.265 L/kg 1compartment NA NA Human Human +DTXSID2044424 TK.Half.Life NA 5.747 hours 1compartment NA NA Rat Human +DTXSID2044424 Css NA 0.04548 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044424 Css NA 0.3137 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044424 Css NA 0.04742 mg/L PBTK NA 50% Rat Human +DTXSID2044424 Css NA 0.2095 mg/L PBTK NA 95% Rat Human +DTXSID2044428 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044428 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044428 Vd NA 2.329 L/kg 1compartment NA NA Human Human DTXSID2044428 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044428 TK.Half.Life NA 1.234 hours 1compartment NA NA Human Human -DTXSID2044428 Css NA 0.03268 mg/L 3compartmentss NA 50% Human Human -DTXSID2044428 Css NA 0.2478 mg/L 3compartmentss NA 95% Human Human -DTXSID2044428 Css NA 0.02481 mg/L PBTK NA 50% Human Human -DTXSID2044428 Css NA 0.1723 mg/L PBTK NA 95% Human Human -DTXSID2044428 Clint NA 46.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044428 Fup NA 0.3292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044428 Vd NA 1.055 L/kg 1compartment NA NA Rat Human +DTXSID2044428 TK.Half.Life NA 4.3 hours 1compartment NA NA Human Human +DTXSID2044428 Css NA 0.13 mg/L 3compartmentss NA 50% Human Human +DTXSID2044428 Css NA 0.8496 mg/L 3compartmentss NA 95% Human Human +DTXSID2044428 Css NA 0.0974 mg/L PBTK NA 50% Human Human +DTXSID2044428 Css NA 0.603 mg/L PBTK NA 95% Human Human +DTXSID2044428 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044428 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044428 Vd NA 1.799 L/kg 1compartment NA NA Rat Human DTXSID2044428 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044428 TK.Half.Life NA 0.4919 hours 1compartment NA NA Rat Human -DTXSID2044428 Css NA 0.01758 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044428 Css NA 0.1128 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044428 Css NA 0.0129 mg/L PBTK NA 50% Rat Human -DTXSID2044428 Css NA 0.07678 mg/L PBTK NA 95% Rat Human -DTXSID2044470 Clint NA 3.676 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044470 Fup NA 0.4437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044470 Vd NA 1.898 L/kg 1compartment NA NA Human Human -DTXSID2044470 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044470 TK.Half.Life NA 6.377 hours 1compartment NA NA Human Human -DTXSID2044470 Css NA 0.314 mg/L 3compartmentss NA 50% Human Human -DTXSID2044470 Css NA 1.737 mg/L 3compartmentss NA 95% Human Human -DTXSID2044470 Css NA 0.2544 mg/L PBTK NA 50% Human Human -DTXSID2044470 Css NA 1.222 mg/L PBTK NA 95% Human Human -DTXSID2044470 Clint NA 3.676 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044470 Fup NA 0.4437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044470 Vd NA 1.532 L/kg 1compartment NA NA Rat Human -DTXSID2044470 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044470 TK.Half.Life NA 2.27 hours 1compartment NA NA Rat Human -DTXSID2044470 Css NA 0.1501 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044470 Css NA 0.6475 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044470 Css NA 0.1184 mg/L PBTK NA 50% Rat Human -DTXSID2044470 Css NA 0.4249 mg/L PBTK NA 95% Rat Human -DTXSID2044472 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044472 Fup NA 0.8369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044472 Vd NA 1.012 L/kg 1compartment NA NA Human Human +DTXSID2044428 TK.Half.Life NA 1.332 hours 1compartment NA NA Rat Human +DTXSID2044428 Css NA 0.01607 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044428 Css NA 0.08364 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044428 Css NA 0.01204 mg/L PBTK NA 50% Rat Human +DTXSID2044428 Css NA 0.06007 mg/L PBTK NA 95% Rat Human +DTXSID2044472 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044472 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044472 Vd NA 0.8726 L/kg 1compartment NA NA Human Human DTXSID2044472 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044472 TK.Half.Life NA 7.998 hours 1compartment NA NA Human Human -DTXSID2044472 Css NA 0.9278 mg/L 3compartmentss NA 50% Human Human -DTXSID2044472 Css NA 5.512 mg/L 3compartmentss NA 95% Human Human -DTXSID2044472 Css NA 0.8073 mg/L PBTK NA 50% Human Human -DTXSID2044472 Css NA 3.678 mg/L PBTK NA 95% Human Human -DTXSID2044472 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044472 Fup NA 0.8369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044472 Vd NA 0.9883 L/kg 1compartment NA NA Rat Human +DTXSID2044472 TK.Half.Life NA 0.7444 hours 1compartment NA NA Human Human +DTXSID2044472 Css NA 0.03026 mg/L 3compartmentss NA 50% Human Human +DTXSID2044472 Css NA 0.3271 mg/L 3compartmentss NA 95% Human Human +DTXSID2044472 Css NA 0.02484 mg/L PBTK NA 50% Human Human +DTXSID2044472 Css NA 0.2239 mg/L PBTK NA 95% Human Human +DTXSID2044472 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044472 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044472 Vd NA 0.8509 L/kg 1compartment NA NA Rat Human DTXSID2044472 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044472 TK.Half.Life NA 2.618 hours 1compartment NA NA Rat Human -DTXSID2044472 Css NA 0.2362 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044472 Css NA 1.446 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044472 Css NA 0.2011 mg/L PBTK NA 50% Rat Human -DTXSID2044472 Css NA 0.8831 mg/L PBTK NA 95% Rat Human -DTXSID2044474 Clint NA 1.714 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044474 Fup NA 0.3746 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044474 Vd NA 1.714 L/kg 1compartment NA NA Human Human +DTXSID2044472 TK.Half.Life NA 0.3575 hours 1compartment NA NA Rat Human +DTXSID2044472 Css NA 0.003518 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044472 Css NA 0.03546 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044472 Css NA 0.002972 mg/L PBTK NA 50% Rat Human +DTXSID2044472 Css NA 0.02384 mg/L PBTK NA 95% Rat Human +DTXSID2044474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044474 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044474 Vd NA 1.25 L/kg 1compartment NA NA Human Human DTXSID2044474 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044474 TK.Half.Life NA 10.7 hours 1compartment NA NA Human Human -DTXSID2044474 Css NA 0.6362 mg/L 3compartmentss NA 50% Human Human -DTXSID2044474 Css NA 3.036 mg/L 3compartmentss NA 95% Human Human -DTXSID2044474 Css NA 0.5056 mg/L PBTK NA 50% Human Human -DTXSID2044474 Css NA 2.074 mg/L PBTK NA 95% Human Human -DTXSID2044474 Clint NA 1.714 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044474 Fup NA 0.3746 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044474 Vd NA 1.387 L/kg 1compartment NA NA Rat Human +DTXSID2044474 TK.Half.Life NA 1.987 hours 1compartment NA NA Human Human +DTXSID2044474 Css NA 0.1013 mg/L 3compartmentss NA 50% Human Human +DTXSID2044474 Css NA 0.6938 mg/L 3compartmentss NA 95% Human Human +DTXSID2044474 Css NA 0.0728 mg/L PBTK NA 50% Human Human +DTXSID2044474 Css NA 0.4687 mg/L PBTK NA 95% Human Human +DTXSID2044474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044474 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044474 Vd NA 1.014 L/kg 1compartment NA NA Rat Human DTXSID2044474 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044474 TK.Half.Life NA 3.713 hours 1compartment NA NA Rat Human -DTXSID2044474 Css NA 0.2787 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044474 Css NA 1.022 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044474 Css NA 0.2136 mg/L PBTK NA 50% Rat Human -DTXSID2044474 Css NA 0.6492 mg/L PBTK NA 95% Rat Human -DTXSID2044503 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044503 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044503 Vd NA 1.298 L/kg 1compartment NA NA Human Human -DTXSID2044503 Days.Css NA 207 Days PBTK NA NA Human Human -DTXSID2044503 TK.Half.Life NA 815 hours 1compartment NA NA Human Human -DTXSID2044503 Css NA 100 mg/L 3compartmentss NA 50% Human Human -DTXSID2044503 Css NA 551.5 mg/L 3compartmentss NA 95% Human Human -DTXSID2044503 Css NA 61.49 mg/L PBTK NA 50% Human Human -DTXSID2044503 Css NA 320.6 mg/L PBTK NA 95% Human Human -DTXSID2044503 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044503 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044503 Vd NA 0.9586 L/kg 1compartment NA NA Rat Human -DTXSID2044503 Days.Css NA 49 Days PBTK NA NA Rat Human -DTXSID2044503 TK.Half.Life NA 167.2 hours 1compartment NA NA Rat Human -DTXSID2044503 Css NA 28.57 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044503 Css NA 132.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044503 Css NA 16.43 mg/L PBTK NA 50% Rat Human -DTXSID2044503 Css NA 72.62 mg/L PBTK NA 95% Rat Human -DTXSID2044507 Clint NA 13.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044507 Fup NA 0.0691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044507 Vd NA 2.026 L/kg 1compartment NA NA Human Human -DTXSID2044507 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044507 TK.Half.Life NA 4.404 hours 1compartment NA NA Human Human -DTXSID2044507 Css NA 0.1844 mg/L 3compartmentss NA 50% Human Human -DTXSID2044507 Css NA 1.537 mg/L 3compartmentss NA 95% Human Human -DTXSID2044507 Css NA 0.1579 mg/L PBTK NA 50% Human Human -DTXSID2044507 Css NA 1.15 mg/L PBTK NA 95% Human Human -DTXSID2044507 Clint NA 13.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044507 Fup NA 0.0691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044507 Vd NA 1.986 L/kg 1compartment NA NA Rat Human -DTXSID2044507 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044507 TK.Half.Life NA 2.619 hours 1compartment NA NA Rat Human -DTXSID2044507 Css NA 0.1031 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044507 Css NA 0.643 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044507 Css NA 0.08528 mg/L PBTK NA 50% Rat Human -DTXSID2044507 Css NA 0.4532 mg/L PBTK NA 95% Rat Human -DTXSID2044509 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044509 Fup NA 0.0139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044509 Vd NA 0.2231 L/kg 1compartment NA NA Human Human -DTXSID2044509 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID2044509 TK.Half.Life NA 103.9 hours 1compartment NA NA Human Human -DTXSID2044509 Css NA 79.16 mg/L 3compartmentss NA 50% Human Human -DTXSID2044509 Css NA 504 mg/L 3compartmentss NA 95% Human Human -DTXSID2044509 Css NA 46.98 mg/L PBTK NA 50% Human Human -DTXSID2044509 Css NA 288.3 mg/L PBTK NA 95% Human Human -DTXSID2044509 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044509 Fup NA 0.0139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044509 Vd NA 0.2176 L/kg 1compartment NA NA Rat Human -DTXSID2044509 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID2044509 TK.Half.Life NA 34.52 hours 1compartment NA NA Rat Human -DTXSID2044509 Css NA 22.86 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044509 Css NA 123 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044509 Css NA 12.6 mg/L PBTK NA 50% Rat Human -DTXSID2044509 Css NA 66.7 mg/L PBTK NA 95% Rat Human -DTXSID2044553 Clint NA 0.298 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044553 Fup NA 0.2545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044553 Vd NA 0.4919 L/kg 1compartment NA NA Human Human +DTXSID2044474 TK.Half.Life NA 0.8283 hours 1compartment NA NA Rat Human +DTXSID2044474 Css NA 0.01274 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044474 Css NA 0.06783 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044474 Css NA 0.009114 mg/L PBTK NA 50% Rat Human +DTXSID2044474 Css NA 0.04515 mg/L PBTK NA 95% Rat Human +DTXSID2044501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044501 Fup 0.031 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044501 Vd NA 2.578 L/kg 1compartment NA NA Human Human +DTXSID2044501 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2044501 TK.Half.Life NA 26.24 hours 1compartment NA NA Human Human +DTXSID2044501 Css NA 1.364 mg/L 3compartmentss NA 50% Human Human +DTXSID2044501 Css NA 9.783 mg/L 3compartmentss NA 95% Human Human +DTXSID2044501 Css NA 0.9118 mg/L PBTK NA 50% Human Human +DTXSID2044501 Css NA 6.303 mg/L PBTK NA 95% Human Human +DTXSID2044501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044501 Fup 0.031 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044501 Vd NA 1.927 L/kg 1compartment NA NA Rat Human +DTXSID2044501 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2044501 TK.Half.Life NA 6.211 hours 1compartment NA NA Rat Human +DTXSID2044501 Css NA 0.1746 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044501 Css NA 1.041 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044501 Css NA 0.1148 mg/L PBTK NA 50% Rat Human +DTXSID2044501 Css NA 0.6683 mg/L PBTK NA 95% Rat Human +DTXSID2044503 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044503 Fup 0.071 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044503 Vd NA 0.2725 L/kg 1compartment NA NA Human Human +DTXSID2044503 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2044503 TK.Half.Life NA 2.391 hours 1compartment NA NA Human Human +DTXSID2044503 Css NA 1.232 mg/L 3compartmentss NA 50% Human Human +DTXSID2044503 Css NA 7.117 mg/L 3compartmentss NA 95% Human Human +DTXSID2044503 Css NA 0.7476 mg/L PBTK NA 50% Human Human +DTXSID2044503 Css NA 4.19 mg/L PBTK NA 95% Human Human +DTXSID2044503 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044503 Fup 0.071 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044503 Vd NA 0.2627 L/kg 1compartment NA NA Rat Human +DTXSID2044503 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2044503 TK.Half.Life NA 1.423 hours 1compartment NA NA Rat Human +DTXSID2044503 Css NA 0.1518 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044503 Css NA 0.6425 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044503 Css NA 0.08912 mg/L PBTK NA 50% Rat Human +DTXSID2044503 Css NA 0.369 mg/L PBTK NA 95% Rat Human +DTXSID2044507 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044507 Fup 0.0754 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044507 Vd NA 2.377 L/kg 1compartment NA NA Human Human +DTXSID2044507 Days.Css NA 46 Days PBTK NA NA Human Human +DTXSID2044507 TK.Half.Life NA 212.6 hours 1compartment NA NA Human Human +DTXSID2044507 Css NA 9.501 mg/L 3compartmentss NA 50% Human Human +DTXSID2044507 Css NA 52.96 mg/L 3compartmentss NA 95% Human Human +DTXSID2044507 Css NA 8.518 mg/L PBTK NA 50% Human Human +DTXSID2044507 Css NA 36.26 mg/L PBTK NA 95% Human Human +DTXSID2044507 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044507 Fup 0.0754 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044507 Vd NA 2.329 L/kg 1compartment NA NA Rat Human +DTXSID2044507 Days.Css NA 14 Days PBTK NA NA Rat Human +DTXSID2044507 TK.Half.Life NA 68.76 hours 1compartment NA NA Rat Human +DTXSID2044507 Css NA 0.5982 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044507 Css NA 2.885 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044507 Css NA 0.5388 mg/L PBTK NA 50% Rat Human +DTXSID2044507 Css NA 1.896 mg/L PBTK NA 95% Rat Human +DTXSID2044509 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044509 Fup 0.073 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044509 Vd NA 0.4143 L/kg 1compartment NA NA Human Human +DTXSID2044509 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID2044509 TK.Half.Life NA 36.73 hours 1compartment NA NA Human Human +DTXSID2044509 Css NA 13.41 mg/L 3compartmentss NA 50% Human Human +DTXSID2044509 Css NA 60.56 mg/L 3compartmentss NA 95% Human Human +DTXSID2044509 Css NA 8.58 mg/L PBTK NA 50% Human Human +DTXSID2044509 Css NA 36.16 mg/L PBTK NA 95% Human Human +DTXSID2044509 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044509 Fup 0.073 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044509 Vd NA 0.4059 L/kg 1compartment NA NA Rat Human +DTXSID2044509 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2044509 TK.Half.Life NA 12.26 hours 1compartment NA NA Rat Human +DTXSID2044509 Css NA 0.8674 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044509 Css NA 3.362 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044509 Css NA 0.5396 mg/L PBTK NA 50% Rat Human +DTXSID2044509 Css NA 1.936 mg/L PBTK NA 95% Rat Human +DTXSID2044553 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044553 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044553 Vd NA 0.4139 L/kg 1compartment NA NA Human Human DTXSID2044553 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044553 TK.Half.Life NA 8.377 hours 1compartment NA NA Human Human -DTXSID2044553 Css NA 1.935 mg/L 3compartmentss NA 50% Human Human -DTXSID2044553 Css NA 7.87 mg/L 3compartmentss NA 95% Human Human -DTXSID2044553 Css NA 1.363 mg/L PBTK NA 50% Human Human -DTXSID2044553 Css NA 4.886 mg/L PBTK NA 95% Human Human -DTXSID2044553 Clint NA 0.298 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044553 Fup NA 0.2545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044553 Vd NA 0.4959 L/kg 1compartment NA NA Rat Human +DTXSID2044553 TK.Half.Life NA 0.4633 hours 1compartment NA NA Human Human +DTXSID2044553 Css NA 0.03629 mg/L 3compartmentss NA 50% Human Human +DTXSID2044553 Css NA 0.3235 mg/L 3compartmentss NA 95% Human Human +DTXSID2044553 Css NA 0.02538 mg/L PBTK NA 50% Human Human +DTXSID2044553 Css NA 0.2116 mg/L PBTK NA 95% Human Human +DTXSID2044553 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044553 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044553 Vd NA 0.4415 L/kg 1compartment NA NA Rat Human DTXSID2044553 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044553 TK.Half.Life NA 3.464 hours 1compartment NA NA Rat Human -DTXSID2044553 Css NA 0.6577 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044553 Css NA 2.152 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044553 Css NA 0.4401 mg/L PBTK NA 50% Rat Human -DTXSID2044553 Css NA 1.267 mg/L PBTK NA 95% Rat Human -DTXSID2044559 Clint NA 26.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044559 Fup NA 0.0166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044559 Vd NA 3.095 L/kg 1compartment NA NA Human Human -DTXSID2044559 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID2044559 TK.Half.Life NA 68.16 hours 1compartment NA NA Human Human -DTXSID2044559 Css NA 2.699 mg/L 3compartmentss NA 50% Human Human -DTXSID2044559 Css NA 16.88 mg/L 3compartmentss NA 95% Human Human -DTXSID2044559 Css NA 1.862 mg/L PBTK NA 50% Human Human -DTXSID2044559 Css NA 11.1 mg/L PBTK NA 95% Human Human -DTXSID2044559 Clint NA 26.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044559 Fup NA 0.0166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044559 Vd NA 2.318 L/kg 1compartment NA NA Rat Human -DTXSID2044559 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID2044559 TK.Half.Life NA 9.61 hours 1compartment NA NA Rat Human -DTXSID2044559 Css NA 1.509 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044559 Css NA 7.503 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044559 Css NA 0.9963 mg/L PBTK NA 50% Rat Human -DTXSID2044559 Css NA 4.823 mg/L PBTK NA 95% Rat Human +DTXSID2044553 TK.Half.Life NA 0.2502 hours 1compartment NA NA Rat Human +DTXSID2044553 Css NA 0.001289 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044553 Css NA 0.01287 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044553 Css NA 0.000882 mg/L PBTK NA 50% Rat Human +DTXSID2044553 Css NA 0.008167 mg/L PBTK NA 95% Rat Human DTXSID2044632 Clint NA 1.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2044632 Fup NA 0.6863 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044632 Vd NA 0.4415 L/kg 1compartment NA NA Human Human +DTXSID2044632 Vd NA 0.5194 L/kg 1compartment NA NA Human Human DTXSID2044632 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044632 TK.Half.Life NA 1.21 hours 1compartment NA NA Human Human -DTXSID2044632 Css NA 0.3106 mg/L 3compartmentss NA 50% Human Human -DTXSID2044632 Css NA 2.275 mg/L 3compartmentss NA 95% Human Human -DTXSID2044632 Css NA 0.2272 mg/L PBTK NA 50% Human Human -DTXSID2044632 Css NA 1.404 mg/L PBTK NA 95% Human Human +DTXSID2044632 TK.Half.Life NA 1.555 hours 1compartment NA NA Human Human +DTXSID2044632 Css NA 0.2796 mg/L 3compartmentss NA 50% Human Human +DTXSID2044632 Css NA 2.091 mg/L 3compartmentss NA 95% Human Human +DTXSID2044632 Css NA 0.2136 mg/L PBTK NA 50% Human Human +DTXSID2044632 Css NA 1.321 mg/L PBTK NA 95% Human Human DTXSID2044632 Clint NA 1.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2044632 Fup NA 0.6863 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044632 Vd NA 0.4643 L/kg 1compartment NA NA Rat Human +DTXSID2044632 Vd NA 0.5333 L/kg 1compartment NA NA Rat Human DTXSID2044632 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044632 TK.Half.Life NA 0.6551 hours 1compartment NA NA Rat Human -DTXSID2044632 Css NA 0.1316 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044632 Css NA 0.867 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044632 Css NA 0.09291 mg/L PBTK NA 50% Rat Human -DTXSID2044632 Css NA 0.502 mg/L PBTK NA 95% Rat Human -DTXSID2044638 Clint NA 68.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044638 Fup NA 0.1336 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044638 Vd NA 1.173 L/kg 1compartment NA NA Human Human +DTXSID2044632 TK.Half.Life NA 0.8114 hours 1compartment NA NA Rat Human +DTXSID2044632 Css NA 0.0084 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044632 Css NA 0.0754 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044632 Css NA 0.006172 mg/L PBTK NA 50% Rat Human +DTXSID2044632 Css NA 0.04651 mg/L PBTK NA 95% Rat Human +DTXSID2044638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044638 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044638 Vd NA 2.373 L/kg 1compartment NA NA Human Human DTXSID2044638 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044638 TK.Half.Life NA 1.492 hours 1compartment NA NA Human Human -DTXSID2044638 Css NA 0.06942 mg/L 3compartmentss NA 50% Human Human -DTXSID2044638 Css NA 0.5737 mg/L 3compartmentss NA 95% Human Human -DTXSID2044638 Css NA 0.04631 mg/L PBTK NA 50% Human Human -DTXSID2044638 Css NA 0.3634 mg/L PBTK NA 95% Human Human -DTXSID2044638 Clint NA 68.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044638 Fup NA 0.1336 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044638 Vd NA 0.9251 L/kg 1compartment NA NA Rat Human +DTXSID2044638 TK.Half.Life NA 6.017 hours 1compartment NA NA Human Human +DTXSID2044638 Css NA 0.2082 mg/L 3compartmentss NA 50% Human Human +DTXSID2044638 Css NA 1.374 mg/L 3compartmentss NA 95% Human Human +DTXSID2044638 Css NA 0.1508 mg/L PBTK NA 50% Human Human +DTXSID2044638 Css NA 0.9498 mg/L PBTK NA 95% Human Human +DTXSID2044638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044638 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044638 Vd NA 1.811 L/kg 1compartment NA NA Rat Human DTXSID2044638 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044638 TK.Half.Life NA 0.5815 hours 1compartment NA NA Rat Human -DTXSID2044638 Css NA 0.0395 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044638 Css NA 0.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044638 Css NA 0.02493 mg/L PBTK NA 50% Rat Human -DTXSID2044638 Css NA 0.1484 mg/L PBTK NA 95% Rat Human -DTXSID2044680 Clint NA 0.3142 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044680 Fup NA 0.9338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044680 Vd NA 1.832 L/kg 1compartment NA NA Human Human -DTXSID2044680 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044680 TK.Half.Life NA 8.449 hours 1compartment NA NA Human Human -DTXSID2044680 Css NA 0.4878 mg/L 3compartmentss NA 50% Human Human -DTXSID2044680 Css NA 3.151 mg/L 3compartmentss NA 95% Human Human -DTXSID2044680 Css NA 0.4912 mg/L PBTK NA 50% Human Human -DTXSID2044680 Css NA 2.218 mg/L PBTK NA 95% Human Human -DTXSID2044680 Clint NA 0.3142 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044680 Fup NA 0.9338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044680 Vd NA 1.865 L/kg 1compartment NA NA Rat Human +DTXSID2044638 TK.Half.Life NA 1.77 hours 1compartment NA NA Rat Human +DTXSID2044638 Css NA 0.0267 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044638 Css NA 0.1322 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044638 Css NA 0.01918 mg/L PBTK NA 50% Rat Human +DTXSID2044638 Css NA 0.09042 mg/L PBTK NA 95% Rat Human +DTXSID2044680 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044680 Fup 0.669 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044680 Vd NA 1.449 L/kg 1compartment NA NA Human Human +DTXSID2044680 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2044680 TK.Half.Life NA 14.01 hours 1compartment NA NA Human Human +DTXSID2044680 Css NA 0.9406 mg/L 3compartmentss NA 50% Human Human +DTXSID2044680 Css NA 6.705 mg/L 3compartmentss NA 95% Human Human +DTXSID2044680 Css NA 0.8794 mg/L PBTK NA 50% Human Human +DTXSID2044680 Css NA 4.533 mg/L PBTK NA 95% Human Human +DTXSID2044680 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044680 Fup 0.669 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044680 Vd NA 1.471 L/kg 1compartment NA NA Rat Human DTXSID2044680 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044680 TK.Half.Life NA 3.531 hours 1compartment NA NA Rat Human -DTXSID2044680 Css NA 0.1482 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044680 Css NA 0.9384 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044680 Css NA 0.1486 mg/L PBTK NA 50% Rat Human -DTXSID2044680 Css NA 0.6101 mg/L PBTK NA 95% Rat Human -DTXSID2044682 Clint NA 0.2327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044682 Fup NA 0.8429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044682 Vd NA 3.282 L/kg 1compartment NA NA Human Human +DTXSID2044680 TK.Half.Life NA 4.847 hours 1compartment NA NA Rat Human +DTXSID2044680 Css NA 0.0566 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044680 Css NA 0.3894 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044680 Css NA 0.05326 mg/L PBTK NA 50% Rat Human +DTXSID2044680 Css NA 0.2497 mg/L PBTK NA 95% Rat Human +DTXSID2044682 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044682 Fup 0.817 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044682 Vd NA 1.946 L/kg 1compartment NA NA Human Human DTXSID2044682 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2044682 TK.Half.Life NA 18.24 hours 1compartment NA NA Human Human -DTXSID2044682 Css NA 0.4655 mg/L 3compartmentss NA 50% Human Human -DTXSID2044682 Css NA 3.507 mg/L 3compartmentss NA 95% Human Human -DTXSID2044682 Css NA 0.5644 mg/L PBTK NA 50% Human Human -DTXSID2044682 Css NA 2.615 mg/L PBTK NA 95% Human Human -DTXSID2044682 Clint NA 0.2327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044682 Fup NA 0.8429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044682 Vd NA 3.341 L/kg 1compartment NA NA Rat Human +DTXSID2044682 TK.Half.Life NA 15.41 hours 1compartment NA NA Human Human +DTXSID2044682 Css NA 0.7666 mg/L 3compartmentss NA 50% Human Human +DTXSID2044682 Css NA 5.373 mg/L 3compartmentss NA 95% Human Human +DTXSID2044682 Css NA 0.7768 mg/L PBTK NA 50% Human Human +DTXSID2044682 Css NA 3.733 mg/L PBTK NA 95% Human Human +DTXSID2044682 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044682 Fup 0.817 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044682 Vd NA 1.978 L/kg 1compartment NA NA Rat Human DTXSID2044682 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044682 TK.Half.Life NA 7.364 hours 1compartment NA NA Rat Human -DTXSID2044682 Css NA 0.1345 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044682 Css NA 1.004 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044682 Css NA 0.1649 mg/L PBTK NA 50% Rat Human -DTXSID2044682 Css NA 0.7069 mg/L PBTK NA 95% Rat Human -DTXSID2044684 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044684 Fup NA 0.275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044684 Vd NA 0.4243 L/kg 1compartment NA NA Human Human +DTXSID2044682 TK.Half.Life NA 5.34 hours 1compartment NA NA Rat Human +DTXSID2044682 Css NA 0.04474 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044682 Css NA 0.316 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044682 Css NA 0.04652 mg/L PBTK NA 50% Rat Human +DTXSID2044682 Css NA 0.2104 mg/L PBTK NA 95% Rat Human +DTXSID2044684 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044684 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044684 Vd NA 0.3533 L/kg 1compartment NA NA Human Human DTXSID2044684 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2044684 TK.Half.Life NA 9.983 hours 1compartment NA NA Human Human -DTXSID2044684 Css NA 2.798 mg/L 3compartmentss NA 50% Human Human -DTXSID2044684 Css NA 10.89 mg/L 3compartmentss NA 95% Human Human -DTXSID2044684 Css NA 1.919 mg/L PBTK NA 50% Human Human -DTXSID2044684 Css NA 6.711 mg/L PBTK NA 95% Human Human -DTXSID2044684 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044684 Fup NA 0.275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044684 Vd NA 0.434 L/kg 1compartment NA NA Rat Human +DTXSID2044684 TK.Half.Life NA 10.39 hours 1compartment NA NA Human Human +DTXSID2044684 Css NA 1.957 mg/L 3compartmentss NA 50% Human Human +DTXSID2044684 Css NA 7.718 mg/L 3compartmentss NA 95% Human Human +DTXSID2044684 Css NA 1.287 mg/L PBTK NA 50% Human Human +DTXSID2044684 Css NA 4.754 mg/L PBTK NA 95% Human Human +DTXSID2044684 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044684 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044684 Vd NA 0.3641 L/kg 1compartment NA NA Rat Human DTXSID2044684 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044684 TK.Half.Life NA 3.48 hours 1compartment NA NA Rat Human -DTXSID2044684 Css NA 0.771 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044684 Css NA 2.545 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044684 Css NA 0.5036 mg/L PBTK NA 50% Rat Human -DTXSID2044684 Css NA 1.473 mg/L PBTK NA 95% Rat Human -DTXSID2044686 Clint NA 57.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044686 Fup NA 0.0842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044686 Vd NA 1.718 L/kg 1compartment NA NA Human Human +DTXSID2044684 TK.Half.Life NA 3.65 hours 1compartment NA NA Rat Human +DTXSID2044684 Css NA 0.0105 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044684 Css NA 0.04232 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044684 Css NA 0.006577 mg/L PBTK NA 50% Rat Human +DTXSID2044684 Css NA 0.02497 mg/L PBTK NA 95% Rat Human +DTXSID2044686 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044686 Fup 0.094 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044686 Vd NA 0.6217 L/kg 1compartment NA NA Human Human DTXSID2044686 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044686 TK.Half.Life NA 3.118 hours 1compartment NA NA Human Human -DTXSID2044686 Css NA 0.1543 mg/L 3compartmentss NA 50% Human Human -DTXSID2044686 Css NA 1.181 mg/L 3compartmentss NA 95% Human Human -DTXSID2044686 Css NA 0.1023 mg/L PBTK NA 50% Human Human -DTXSID2044686 Css NA 0.7577 mg/L PBTK NA 95% Human Human -DTXSID2044686 Clint NA 57.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044686 Fup NA 0.0842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044686 Vd NA 1.302 L/kg 1compartment NA NA Rat Human +DTXSID2044686 TK.Half.Life NA 4.201 hours 1compartment NA NA Human Human +DTXSID2044686 Css NA 0.9698 mg/L 3compartmentss NA 50% Human Human +DTXSID2044686 Css NA 6.76 mg/L 3compartmentss NA 95% Human Human +DTXSID2044686 Css NA 0.6098 mg/L PBTK NA 50% Human Human +DTXSID2044686 Css NA 4.068 mg/L PBTK NA 95% Human Human +DTXSID2044686 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044686 Fup 0.094 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044686 Vd NA 0.5172 L/kg 1compartment NA NA Rat Human DTXSID2044686 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044686 TK.Half.Life NA 1.113 hours 1compartment NA NA Rat Human -DTXSID2044686 Css NA 0.08755 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044686 Css NA 0.5487 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044686 Css NA 0.05457 mg/L PBTK NA 50% Rat Human -DTXSID2044686 Css NA 0.3244 mg/L PBTK NA 95% Rat Human -DTXSID2044713 Clint NA 0.01884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044713 Fup NA 0.007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044713 Vd NA 0.288 L/kg 1compartment NA NA Human Human -DTXSID2044713 Days.Css NA 63 Days PBTK NA NA Human Human -DTXSID2044713 TK.Half.Life NA 259.8 hours 1compartment NA NA Human Human -DTXSID2044713 Css NA 153.2 mg/L 3compartmentss NA 50% Human Human -DTXSID2044713 Css NA 963.6 mg/L 3compartmentss NA 95% Human Human -DTXSID2044713 Css NA 89.79 mg/L PBTK NA 50% Human Human -DTXSID2044713 Css NA 565.9 mg/L PBTK NA 95% Human Human -DTXSID2044713 Clint NA 0.01884 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044713 Fup NA 0.007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044713 Vd NA 0.2392 L/kg 1compartment NA NA Rat Human -DTXSID2044713 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID2044713 TK.Half.Life NA 74.28 hours 1compartment NA NA Rat Human -DTXSID2044713 Css NA 45.07 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044713 Css NA 250.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044713 Css NA 24.6 mg/L PBTK NA 50% Rat Human -DTXSID2044713 Css NA 135.7 mg/L PBTK NA 95% Rat Human -DTXSID2044715 Clint NA 16.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044715 Fup NA 0.2653 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044715 Vd NA 1.984 L/kg 1compartment NA NA Human Human +DTXSID2044686 TK.Half.Life NA 2.085 hours 1compartment NA NA Rat Human +DTXSID2044686 Css NA 0.1206 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044686 Css NA 0.6151 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044686 Css NA 0.07384 mg/L PBTK NA 50% Rat Human +DTXSID2044686 Css NA 0.3561 mg/L PBTK NA 95% Rat Human +DTXSID2044713 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044713 Fup 0.055 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044713 Vd NA 0.1835 L/kg 1compartment NA NA Human Human +DTXSID2044713 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2044713 TK.Half.Life NA 1.866 hours 1compartment NA NA Human Human +DTXSID2044713 Css NA 0.922 mg/L 3compartmentss NA 50% Human Human +DTXSID2044713 Css NA 7.096 mg/L 3compartmentss NA 95% Human Human +DTXSID2044713 Css NA 0.5414 mg/L PBTK NA 50% Human Human +DTXSID2044713 Css NA 4.11 mg/L PBTK NA 95% Human Human +DTXSID2044713 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044713 Fup 0.055 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044713 Vd NA 0.1851 L/kg 1compartment NA NA Rat Human +DTXSID2044713 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2044713 TK.Half.Life NA 1.177 hours 1compartment NA NA Rat Human +DTXSID2044713 Css NA 0.009527 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044713 Css NA 0.05988 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044713 Css NA 0.005263 mg/L PBTK NA 50% Rat Human +DTXSID2044713 Css NA 0.03267 mg/L PBTK NA 95% Rat Human +DTXSID2044715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044715 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044715 Vd NA 1.977 L/kg 1compartment NA NA Human Human DTXSID2044715 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044715 TK.Half.Life NA 3.788 hours 1compartment NA NA Human Human -DTXSID2044715 Css NA 0.1448 mg/L 3compartmentss NA 50% Human Human -DTXSID2044715 Css NA 0.8902 mg/L 3compartmentss NA 95% Human Human -DTXSID2044715 Css NA 0.1098 mg/L PBTK NA 50% Human Human -DTXSID2044715 Css NA 0.6318 mg/L PBTK NA 95% Human Human -DTXSID2044715 Clint NA 16.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044715 Fup NA 0.2653 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044715 Vd NA 1.577 L/kg 1compartment NA NA Rat Human +DTXSID2044715 TK.Half.Life NA 4.263 hours 1compartment NA NA Human Human +DTXSID2044715 Css NA 0.1668 mg/L 3compartmentss NA 50% Human Human +DTXSID2044715 Css NA 1.063 mg/L 3compartmentss NA 95% Human Human +DTXSID2044715 Css NA 0.1201 mg/L PBTK NA 50% Human Human +DTXSID2044715 Css NA 0.7315 mg/L PBTK NA 95% Human Human +DTXSID2044715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044715 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044715 Vd NA 1.541 L/kg 1compartment NA NA Rat Human DTXSID2044715 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044715 TK.Half.Life NA 1.371 hours 1compartment NA NA Rat Human -DTXSID2044715 Css NA 0.07718 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044715 Css NA 0.381 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044715 Css NA 0.05643 mg/L PBTK NA 50% Rat Human -DTXSID2044715 Css NA 0.2585 mg/L PBTK NA 95% Rat Human -DTXSID2044717 Clint NA 6.237 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044717 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044717 Vd NA 2.316 L/kg 1compartment NA NA Human Human -DTXSID2044717 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID2044717 TK.Half.Life NA 108 hours 1compartment NA NA Human Human -DTXSID2044717 Css NA 7.232 mg/L 3compartmentss NA 50% Human Human -DTXSID2044717 Css NA 50.38 mg/L 3compartmentss NA 95% Human Human -DTXSID2044717 Css NA 4.692 mg/L PBTK NA 50% Human Human -DTXSID2044717 Css NA 31.4 mg/L PBTK NA 95% Human Human -DTXSID2044717 Clint NA 6.237 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044717 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044717 Vd NA 1.723 L/kg 1compartment NA NA Rat Human -DTXSID2044717 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID2044717 TK.Half.Life NA 28.68 hours 1compartment NA NA Rat Human -DTXSID2044717 Css NA 3.932 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044717 Css NA 21.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044717 Css NA 2.424 mg/L PBTK NA 50% Rat Human -DTXSID2044717 Css NA 12.63 mg/L PBTK NA 95% Rat Human -DTXSID2044719 Clint NA 123.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044719 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044719 Vd NA 2.117 L/kg 1compartment NA NA Human Human -DTXSID2044719 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044719 TK.Half.Life NA 6.802 hours 1compartment NA NA Human Human -DTXSID2044719 Css NA 0.3837 mg/L 3compartmentss NA 50% Human Human -DTXSID2044719 Css NA 3.097 mg/L 3compartmentss NA 95% Human Human -DTXSID2044719 Css NA 0.2487 mg/L PBTK NA 50% Human Human -DTXSID2044719 Css NA 1.909 mg/L PBTK NA 95% Human Human -DTXSID2044719 Clint NA 123.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044719 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044719 Vd NA 1.572 L/kg 1compartment NA NA Rat Human -DTXSID2044719 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044719 TK.Half.Life NA 2.116 hours 1compartment NA NA Rat Human -DTXSID2044719 Css NA 0.2192 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044719 Css NA 1.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044719 Css NA 0.1329 mg/L PBTK NA 50% Rat Human -DTXSID2044719 Css NA 0.8808 mg/L PBTK NA 95% Rat Human -DTXSID2044763 Clint NA 73.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044763 Fup NA 0.1338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044763 Vd NA 2.073 L/kg 1compartment NA NA Human Human +DTXSID2044715 TK.Half.Life NA 1.504 hours 1compartment NA NA Rat Human +DTXSID2044715 Css NA 0.02123 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044715 Css NA 0.1066 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044715 Css NA 0.01523 mg/L PBTK NA 50% Rat Human +DTXSID2044715 Css NA 0.07357 mg/L PBTK NA 95% Rat Human +DTXSID2044717 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044717 Fup 0.0299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044717 Vd NA 2.383 L/kg 1compartment NA NA Human Human +DTXSID2044717 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2044717 TK.Half.Life NA 21.87 hours 1compartment NA NA Human Human +DTXSID2044717 Css NA 1.257 mg/L 3compartmentss NA 50% Human Human +DTXSID2044717 Css NA 9.692 mg/L 3compartmentss NA 95% Human Human +DTXSID2044717 Css NA 0.8294 mg/L PBTK NA 50% Human Human +DTXSID2044717 Css NA 6.176 mg/L PBTK NA 95% Human Human +DTXSID2044717 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044717 Fup 0.0299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044717 Vd NA 1.779 L/kg 1compartment NA NA Rat Human +DTXSID2044717 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2044717 TK.Half.Life NA 5.854 hours 1compartment NA NA Rat Human +DTXSID2044717 Css NA 0.1643 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044717 Css NA 0.9855 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044717 Css NA 0.1064 mg/L PBTK NA 50% Rat Human +DTXSID2044717 Css NA 0.5973 mg/L PBTK NA 95% Rat Human +DTXSID2044719 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044719 Fup 0.00662 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044719 Vd NA 1.541 L/kg 1compartment NA NA Human Human +DTXSID2044719 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2044719 TK.Half.Life NA 30.15 hours 1compartment NA NA Human Human +DTXSID2044719 Css NA 3.237 mg/L 3compartmentss NA 50% Human Human +DTXSID2044719 Css NA 29.66 mg/L 3compartmentss NA 95% Human Human +DTXSID2044719 Css NA 1.988 mg/L PBTK NA 50% Human Human +DTXSID2044719 Css NA 17.85 mg/L PBTK NA 95% Human Human +DTXSID2044719 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044719 Fup 0.00662 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044719 Vd NA 1.135 L/kg 1compartment NA NA Rat Human +DTXSID2044719 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2044719 TK.Half.Life NA 11.47 hours 1compartment NA NA Rat Human +DTXSID2044719 Css NA 0.4216 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044719 Css NA 3.092 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044719 Css NA 0.2538 mg/L PBTK NA 50% Rat Human +DTXSID2044719 Css NA 1.786 mg/L PBTK NA 95% Rat Human +DTXSID2044763 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044763 Fup 0.205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044763 Vd NA 2.6 L/kg 1compartment NA NA Human Human DTXSID2044763 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044763 TK.Half.Life NA 2.895 hours 1compartment NA NA Human Human -DTXSID2044763 Css NA 0.08718 mg/L 3compartmentss NA 50% Human Human -DTXSID2044763 Css NA 0.6357 mg/L 3compartmentss NA 95% Human Human -DTXSID2044763 Css NA 0.06018 mg/L PBTK NA 50% Human Human -DTXSID2044763 Css NA 0.4081 mg/L PBTK NA 95% Human Human -DTXSID2044763 Clint NA 73.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044763 Fup NA 0.1338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044763 Vd NA 1.578 L/kg 1compartment NA NA Rat Human +DTXSID2044763 TK.Half.Life NA 7.497 hours 1compartment NA NA Human Human +DTXSID2044763 Css NA 0.2478 mg/L 3compartmentss NA 50% Human Human +DTXSID2044763 Css NA 1.593 mg/L 3compartmentss NA 95% Human Human +DTXSID2044763 Css NA 0.1798 mg/L PBTK NA 50% Human Human +DTXSID2044763 Css NA 1.092 mg/L PBTK NA 95% Human Human +DTXSID2044763 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044763 Fup 0.205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044763 Vd NA 1.977 L/kg 1compartment NA NA Rat Human DTXSID2044763 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044763 TK.Half.Life NA 0.957 hours 1compartment NA NA Rat Human -DTXSID2044763 Css NA 0.0486 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044763 Css NA 0.2721 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044763 Css NA 0.03202 mg/L PBTK NA 50% Rat Human -DTXSID2044763 Css NA 0.1698 mg/L PBTK NA 95% Rat Human -DTXSID2044767 Clint NA 2.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044767 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044767 Vd NA 1.007 L/kg 1compartment NA NA Human Human +DTXSID2044763 TK.Half.Life NA 1.96 hours 1compartment NA NA Rat Human +DTXSID2044763 Css NA 0.03167 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044763 Css NA 0.1597 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044763 Css NA 0.02284 mg/L PBTK NA 50% Rat Human +DTXSID2044763 Css NA 0.1107 mg/L PBTK NA 95% Rat Human +DTXSID2044765 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044765 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044765 Vd NA 1.755 L/kg 1compartment NA NA Human Human +DTXSID2044765 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2044765 TK.Half.Life NA 4.696 hours 1compartment NA NA Human Human +DTXSID2044765 Css NA 0.2714 mg/L 3compartmentss NA 50% Human Human +DTXSID2044765 Css NA 1.979 mg/L 3compartmentss NA 95% Human Human +DTXSID2044765 Css NA 0.1832 mg/L PBTK NA 50% Human Human +DTXSID2044765 Css NA 1.263 mg/L PBTK NA 95% Human Human +DTXSID2044765 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044765 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044765 Vd NA 1.342 L/kg 1compartment NA NA Rat Human +DTXSID2044765 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2044765 TK.Half.Life NA 1.7 hours 1compartment NA NA Rat Human +DTXSID2044765 Css NA 0.03493 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044765 Css NA 0.2011 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044765 Css NA 0.02333 mg/L PBTK NA 50% Rat Human +DTXSID2044765 Css NA 0.1263 mg/L PBTK NA 95% Rat Human +DTXSID2044767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044767 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044767 Vd NA 0.7181 L/kg 1compartment NA NA Human Human DTXSID2044767 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044767 TK.Half.Life NA 1.481 hours 1compartment NA NA Human Human -DTXSID2044767 Css NA 0.1396 mg/L 3compartmentss NA 50% Human Human -DTXSID2044767 Css NA 1.132 mg/L 3compartmentss NA 95% Human Human -DTXSID2044767 Css NA 0.122 mg/L PBTK NA 50% Human Human -DTXSID2044767 Css NA 0.806 mg/L PBTK NA 95% Human Human -DTXSID2044767 Clint NA 2.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044767 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044767 Vd NA 1.014 L/kg 1compartment NA NA Rat Human +DTXSID2044767 TK.Half.Life NA 8.124 hours 1compartment NA NA Human Human +DTXSID2044767 Css NA 1.253 mg/L 3compartmentss NA 50% Human Human +DTXSID2044767 Css NA 8.513 mg/L 3compartmentss NA 95% Human Human +DTXSID2044767 Css NA 0.9972 mg/L PBTK NA 50% Human Human +DTXSID2044767 Css NA 5.372 mg/L PBTK NA 95% Human Human +DTXSID2044767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044767 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044767 Vd NA 0.7211 L/kg 1compartment NA NA Rat Human DTXSID2044767 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044767 TK.Half.Life NA 0.7779 hours 1compartment NA NA Rat Human -DTXSID2044767 Css NA 0.06056 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044767 Css NA 0.4391 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044767 Css NA 0.0528 mg/L PBTK NA 50% Rat Human -DTXSID2044767 Css NA 0.2747 mg/L PBTK NA 95% Rat Human +DTXSID2044767 TK.Half.Life NA 2.769 hours 1compartment NA NA Rat Human +DTXSID2044767 Css NA 0.07588 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044767 Css NA 0.4907 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044767 Css NA 0.06016 mg/L PBTK NA 50% Rat Human +DTXSID2044767 Css NA 0.2977 mg/L PBTK NA 95% Rat Human DTXSID2044840 Clint NA 0.07111 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2044840 Fup NA 0.5474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044840 Vd NA 0.5571 L/kg 1compartment NA NA Human Human -DTXSID2044840 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044840 TK.Half.Life NA 5.786 hours 1compartment NA NA Human Human -DTXSID2044840 Css NA 1.166 mg/L 3compartmentss NA 50% Human Human -DTXSID2044840 Css NA 7.136 mg/L 3compartmentss NA 95% Human Human -DTXSID2044840 Css NA 0.8966 mg/L PBTK NA 50% Human Human -DTXSID2044840 Css NA 4.498 mg/L PBTK NA 95% Human Human +DTXSID2044840 Vd NA 1.822 L/kg 1compartment NA NA Human Human +DTXSID2044840 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2044840 TK.Half.Life NA 19.65 hours 1compartment NA NA Human Human +DTXSID2044840 Css NA 0.6158 mg/L 3compartmentss NA 50% Human Human +DTXSID2044840 Css NA 5.087 mg/L 3compartmentss NA 95% Human Human +DTXSID2044840 Css NA 0.7933 mg/L PBTK NA 50% Human Human +DTXSID2044840 Css NA 4.008 mg/L PBTK NA 95% Human Human DTXSID2044840 Clint NA 0.07111 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2044840 Fup NA 0.5474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044840 Vd NA 0.5816 L/kg 1compartment NA NA Rat Human +DTXSID2044840 Vd NA 1.815 L/kg 1compartment NA NA Rat Human DTXSID2044840 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044840 TK.Half.Life NA 2.194 hours 1compartment NA NA Rat Human -DTXSID2044840 Css NA 0.3408 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044840 Css NA 2.015 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044840 Css NA 0.249 mg/L PBTK NA 50% Rat Human -DTXSID2044840 Css NA 1.171 mg/L PBTK NA 95% Rat Human -DTXSID2044842 Clint NA 1055 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044842 Fup NA 0.0707 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044842 Vd NA 2.887 L/kg 1compartment NA NA Human Human -DTXSID2044842 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044842 TK.Half.Life NA 1.531 hours 1compartment NA NA Human Human -DTXSID2044842 Css NA 0.0008346 mg/L 3compartmentss NA 50% Human Human -DTXSID2044842 Css NA 0.007238 mg/L 3compartmentss NA 95% Human Human -DTXSID2044842 Css NA 0.0008114 mg/L PBTK NA 50% Human Human -DTXSID2044842 Css NA 0.005913 mg/L PBTK NA 95% Human Human -DTXSID2044842 Clint NA 1055 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044842 Fup NA 0.0707 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044842 Vd NA 2.78 L/kg 1compartment NA NA Rat Human -DTXSID2044842 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044842 TK.Half.Life NA 0.6496 hours 1compartment NA NA Rat Human -DTXSID2044842 Css NA 0.0004516 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044842 Css NA 0.003299 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044842 Css NA 0.000434 mg/L PBTK NA 50% Rat Human -DTXSID2044842 Css NA 0.002625 mg/L PBTK NA 95% Rat Human -DTXSID2044844 Clint NA 42.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044844 Fup NA 0.3138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044844 Vd NA 3.315 L/kg 1compartment NA NA Human Human +DTXSID2044840 TK.Half.Life NA 6.947 hours 1compartment NA NA Rat Human +DTXSID2044840 Css NA 0.01196 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044840 Css NA 0.1275 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044840 Css NA 0.01532 mg/L PBTK NA 50% Rat Human +DTXSID2044840 Css NA 0.1024 mg/L PBTK NA 95% Rat Human +DTXSID2044842 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044842 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044842 Vd NA 2.976 L/kg 1compartment NA NA Human Human +DTXSID2044842 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID2044842 TK.Half.Life NA 53.48 hours 1compartment NA NA Human Human +DTXSID2044842 Css NA 2.214 mg/L 3compartmentss NA 50% Human Human +DTXSID2044842 Css NA 15.14 mg/L 3compartmentss NA 95% Human Human +DTXSID2044842 Css NA 1.514 mg/L PBTK NA 50% Human Human +DTXSID2044842 Css NA 10.06 mg/L PBTK NA 95% Human Human +DTXSID2044842 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044842 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044842 Vd NA 2.228 L/kg 1compartment NA NA Rat Human +DTXSID2044842 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID2044842 TK.Half.Life NA 8.785 hours 1compartment NA NA Rat Human +DTXSID2044842 Css NA 0.2906 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044842 Css NA 1.605 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044842 Css NA 0.1964 mg/L PBTK NA 50% Rat Human +DTXSID2044842 Css NA 1.063 mg/L PBTK NA 95% Rat Human +DTXSID2044844 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044844 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044844 Vd NA 2.66 L/kg 1compartment NA NA Human Human DTXSID2044844 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044844 TK.Half.Life NA 1.931 hours 1compartment NA NA Human Human -DTXSID2044844 Css NA 0.01305 mg/L 3compartmentss NA 50% Human Human -DTXSID2044844 Css NA 0.1217 mg/L 3compartmentss NA 95% Human Human -DTXSID2044844 Css NA 0.0172 mg/L PBTK NA 50% Human Human -DTXSID2044844 Css NA 0.1222 mg/L PBTK NA 95% Human Human -DTXSID2044844 Clint NA 42.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044844 Fup NA 0.3138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044844 Vd NA 3.285 L/kg 1compartment NA NA Rat Human +DTXSID2044844 TK.Half.Life NA 2.173 hours 1compartment NA NA Human Human +DTXSID2044844 Css NA 0.0274 mg/L 3compartmentss NA 50% Human Human +DTXSID2044844 Css NA 0.2534 mg/L 3compartmentss NA 95% Human Human +DTXSID2044844 Css NA 0.032 mg/L PBTK NA 50% Human Human +DTXSID2044844 Css NA 0.2283 mg/L PBTK NA 95% Human Human +DTXSID2044844 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044844 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044844 Vd NA 2.628 L/kg 1compartment NA NA Rat Human DTXSID2044844 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044844 TK.Half.Life NA 0.9824 hours 1compartment NA NA Rat Human -DTXSID2044844 Css NA 0.006868 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044844 Css NA 0.05111 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044844 Css NA 0.009083 mg/L PBTK NA 50% Rat Human -DTXSID2044844 Css NA 0.05211 mg/L PBTK NA 95% Rat Human -DTXSID2044846 Clint NA 8.628 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044846 Fup NA 0.3 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044846 Vd NA 0.6854 L/kg 1compartment NA NA Human Human +DTXSID2044844 TK.Half.Life NA 1.165 hours 1compartment NA NA Rat Human +DTXSID2044844 Css NA 0.003292 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044844 Css NA 0.02439 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044844 Css NA 0.003976 mg/L PBTK NA 50% Rat Human +DTXSID2044844 Css NA 0.02226 mg/L PBTK NA 95% Rat Human +DTXSID2044846 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044846 Fup 0.0976 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044846 Vd NA 0.5433 L/kg 1compartment NA NA Human Human DTXSID2044846 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044846 TK.Half.Life NA 1.444 hours 1compartment NA NA Human Human -DTXSID2044846 Css NA 0.1773 mg/L 3compartmentss NA 50% Human Human -DTXSID2044846 Css NA 1.126 mg/L 3compartmentss NA 95% Human Human -DTXSID2044846 Css NA 0.1259 mg/L PBTK NA 50% Human Human -DTXSID2044846 Css NA 0.7427 mg/L PBTK NA 95% Human Human -DTXSID2044846 Clint NA 8.628 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044846 Fup NA 0.3 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044846 Vd NA 0.6079 L/kg 1compartment NA NA Rat Human +DTXSID2044846 TK.Half.Life NA 1.425 hours 1compartment NA NA Human Human +DTXSID2044846 Css NA 0.2895 mg/L 3compartmentss NA 50% Human Human +DTXSID2044846 Css NA 2.402 mg/L 3compartmentss NA 95% Human Human +DTXSID2044846 Css NA 0.1805 mg/L PBTK NA 50% Human Human +DTXSID2044846 Css NA 1.423 mg/L PBTK NA 95% Human Human +DTXSID2044846 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044846 Fup 0.0976 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044846 Vd NA 0.4521 L/kg 1compartment NA NA Rat Human DTXSID2044846 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044846 TK.Half.Life NA 0.7136 hours 1compartment NA NA Rat Human -DTXSID2044846 Css NA 0.09255 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044846 Css NA 0.4397 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044846 Css NA 0.06244 mg/L PBTK NA 50% Rat Human -DTXSID2044846 Css NA 0.2678 mg/L PBTK NA 95% Rat Human -DTXSID2044848 Clint NA 3.097 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044848 Fup NA 0.66 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044848 Vd NA 0.7223 L/kg 1compartment NA NA Human Human +DTXSID2044846 TK.Half.Life NA 0.6931 hours 1compartment NA NA Rat Human +DTXSID2044846 Css NA 0.03815 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044846 Css NA 0.2371 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044846 Css NA 0.02305 mg/L PBTK NA 50% Rat Human +DTXSID2044846 Css NA 0.1393 mg/L PBTK NA 95% Rat Human +DTXSID2044848 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044848 Fup 0.861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044848 Vd NA 0.9345 L/kg 1compartment NA NA Human Human DTXSID2044848 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044848 TK.Half.Life NA 1.489 hours 1compartment NA NA Human Human -DTXSID2044848 Css NA 0.198 mg/L 3compartmentss NA 50% Human Human -DTXSID2044848 Css NA 1.578 mg/L 3compartmentss NA 95% Human Human -DTXSID2044848 Css NA 0.1578 mg/L PBTK NA 50% Human Human -DTXSID2044848 Css NA 1.018 mg/L PBTK NA 95% Human Human -DTXSID2044848 Clint NA 3.097 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044848 Fup NA 0.66 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044848 Vd NA 0.721 L/kg 1compartment NA NA Rat Human +DTXSID2044848 TK.Half.Life NA 0.6964 hours 1compartment NA NA Human Human +DTXSID2044848 Css NA 0.02456 mg/L 3compartmentss NA 50% Human Human +DTXSID2044848 Css NA 0.2731 mg/L 3compartmentss NA 95% Human Human +DTXSID2044848 Css NA 0.02041 mg/L PBTK NA 50% Human Human +DTXSID2044848 Css NA 0.194 mg/L PBTK NA 95% Human Human +DTXSID2044848 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044848 Fup 0.861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044848 Vd NA 0.9159 L/kg 1compartment NA NA Rat Human DTXSID2044848 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044848 TK.Half.Life NA 0.7943 hours 1compartment NA NA Rat Human -DTXSID2044848 Css NA 0.08868 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044848 Css NA 0.6547 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044848 Css NA 0.06868 mg/L PBTK NA 50% Rat Human -DTXSID2044848 Css NA 0.3915 mg/L PBTK NA 95% Rat Human +DTXSID2044848 TK.Half.Life NA 0.3279 hours 1compartment NA NA Rat Human +DTXSID2044848 Css NA 0.002889 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044848 Css NA 0.02577 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044848 Css NA 0.002492 mg/L PBTK NA 50% Rat Human +DTXSID2044848 Css NA 0.0183 mg/L PBTK NA 95% Rat Human DTXSID2044890 Clint 56.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2044890 Fup 0.0426 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2044890 Vd NA 1.529 L/kg 1compartment NA NA Human Human +DTXSID2044890 Vd NA 1.614 L/kg 1compartment NA NA Human Human DTXSID2044890 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044890 TK.Half.Life NA 3.97 hours 1compartment NA NA Human Human -DTXSID2044890 Css NA 0.2331 mg/L 3compartmentss NA 50% Human Human -DTXSID2044890 Css NA 1.812 mg/L 3compartmentss NA 95% Human Human -DTXSID2044890 Css NA 0.1516 mg/L PBTK NA 50% Human Human -DTXSID2044890 Css NA 1.127 mg/L PBTK NA 95% Human Human +DTXSID2044890 TK.Half.Life NA 4.252 hours 1compartment NA NA Human Human +DTXSID2044890 Css NA 0.2294 mg/L 3compartmentss NA 50% Human Human +DTXSID2044890 Css NA 1.738 mg/L 3compartmentss NA 95% Human Human +DTXSID2044890 Css NA 0.1492 mg/L PBTK NA 50% Human Human +DTXSID2044890 Css NA 1.101 mg/L PBTK NA 95% Human Human DTXSID2044890 Clint 56.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2044890 Fup 0.0426 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2044890 Vd NA 1.145 L/kg 1compartment NA NA Rat Human +DTXSID2044890 Vd NA 1.209 L/kg 1compartment NA NA Rat Human DTXSID2044890 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044890 TK.Half.Life NA 1.486 hours 1compartment NA NA Rat Human -DTXSID2044890 Css NA 0.1304 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044890 Css NA 0.7836 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044890 Css NA 0.0799 mg/L PBTK NA 50% Rat Human -DTXSID2044890 Css NA 0.4605 mg/L PBTK NA 95% Rat Human -DTXSID2044892 Clint NA 36.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044892 Fup NA 0.034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044892 Vd NA 1.637 L/kg 1compartment NA NA Human Human +DTXSID2044890 TK.Half.Life NA 1.56 hours 1compartment NA NA Rat Human +DTXSID2044890 Css NA 0.03004 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044890 Css NA 0.1883 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044890 Css NA 0.0192 mg/L PBTK NA 50% Rat Human +DTXSID2044890 Css NA 0.1167 mg/L PBTK NA 95% Rat Human +DTXSID2044892 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044892 Fup 0.0388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044892 Vd NA 0.691 L/kg 1compartment NA NA Human Human DTXSID2044892 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044892 TK.Half.Life NA 6.863 hours 1compartment NA NA Human Human -DTXSID2044892 Css NA 0.5812 mg/L 3compartmentss NA 50% Human Human -DTXSID2044892 Css NA 4.272 mg/L 3compartmentss NA 95% Human Human -DTXSID2044892 Css NA 0.369 mg/L PBTK NA 50% Human Human -DTXSID2044892 Css NA 2.62 mg/L PBTK NA 95% Human Human -DTXSID2044892 Clint NA 36.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044892 Fup NA 0.034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044892 Vd NA 1.221 L/kg 1compartment NA NA Rat Human +DTXSID2044892 TK.Half.Life NA 3.593 hours 1compartment NA NA Human Human +DTXSID2044892 Css NA 0.7876 mg/L 3compartmentss NA 50% Human Human +DTXSID2044892 Css NA 7.131 mg/L 3compartmentss NA 95% Human Human +DTXSID2044892 Css NA 0.4818 mg/L PBTK NA 50% Human Human +DTXSID2044892 Css NA 4.23 mg/L PBTK NA 95% Human Human +DTXSID2044892 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044892 Fup 0.0388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044892 Vd NA 0.5371 L/kg 1compartment NA NA Rat Human DTXSID2044892 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044892 TK.Half.Life NA 2.525 hours 1compartment NA NA Rat Human -DTXSID2044892 Css NA 0.3245 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044892 Css NA 2.004 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044892 Css NA 0.1939 mg/L PBTK NA 50% Rat Human -DTXSID2044892 Css NA 1.16 mg/L PBTK NA 95% Rat Human -DTXSID2044894 Clint NA 2.615 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044894 Fup NA 0.5675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044894 Vd NA 1.88 L/kg 1compartment NA NA Human Human -DTXSID2044894 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044894 TK.Half.Life NA 4.519 hours 1compartment NA NA Human Human -DTXSID2044894 Css NA 0.1931 mg/L 3compartmentss NA 50% Human Human -DTXSID2044894 Css NA 1.803 mg/L 3compartmentss NA 95% Human Human -DTXSID2044894 Css NA 0.1972 mg/L PBTK NA 50% Human Human -DTXSID2044894 Css NA 1.274 mg/L PBTK NA 95% Human Human -DTXSID2044894 Clint NA 2.615 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044894 Fup NA 0.5675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044894 Vd NA 1.849 L/kg 1compartment NA NA Rat Human -DTXSID2044894 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044894 TK.Half.Life NA 2.441 hours 1compartment NA NA Rat Human -DTXSID2044894 Css NA 0.08422 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044894 Css NA 0.7689 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044894 Css NA 0.08507 mg/L PBTK NA 50% Rat Human -DTXSID2044894 Css NA 0.493 mg/L PBTK NA 95% Rat Human +DTXSID2044892 TK.Half.Life NA 1.702 hours 1compartment NA NA Rat Human +DTXSID2044892 Css NA 0.1034 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044892 Css NA 0.7753 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044892 Css NA 0.061 mg/L PBTK NA 50% Rat Human +DTXSID2044892 Css NA 0.442 mg/L PBTK NA 95% Rat Human DTXSID2044896 Clint NA 56.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2044896 Fup NA 0.0628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044896 Vd NA 1.219 L/kg 1compartment NA NA Human Human +DTXSID2044896 Vd NA 0.4818 L/kg 1compartment NA NA Human Human DTXSID2044896 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044896 TK.Half.Life NA 2.451 hours 1compartment NA NA Human Human -DTXSID2044896 Css NA 0.1901 mg/L 3compartmentss NA 50% Human Human -DTXSID2044896 Css NA 1.532 mg/L 3compartmentss NA 95% Human Human -DTXSID2044896 Css NA 0.1212 mg/L PBTK NA 50% Human Human -DTXSID2044896 Css NA 0.9451 mg/L PBTK NA 95% Human Human +DTXSID2044896 TK.Half.Life NA 0.9482 hours 1compartment NA NA Human Human +DTXSID2044896 Css NA 0.1584 mg/L 3compartmentss NA 50% Human Human +DTXSID2044896 Css NA 1.351 mg/L 3compartmentss NA 95% Human Human +DTXSID2044896 Css NA 0.09658 mg/L PBTK NA 50% Human Human +DTXSID2044896 Css NA 0.7999 mg/L PBTK NA 95% Human Human DTXSID2044896 Clint NA 56.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2044896 Fup NA 0.0628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044896 Vd NA 0.9285 L/kg 1compartment NA NA Rat Human +DTXSID2044896 Vd NA 0.4058 L/kg 1compartment NA NA Rat Human DTXSID2044896 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044896 TK.Half.Life NA 0.9737 hours 1compartment NA NA Rat Human -DTXSID2044896 Css NA 0.1098 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044896 Css NA 0.6666 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044896 Css NA 0.06577 mg/L PBTK NA 50% Rat Human -DTXSID2044896 Css NA 0.3877 mg/L PBTK NA 95% Rat Human -DTXSID2044898 Clint NA 29.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044898 Fup NA 0.2472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044898 Vd NA 1.378 L/kg 1compartment NA NA Human Human +DTXSID2044896 TK.Half.Life NA 0.4519 hours 1compartment NA NA Rat Human +DTXSID2044896 Css NA 0.007887 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044896 Css NA 0.07054 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044896 Css NA 0.004689 mg/L PBTK NA 50% Rat Human +DTXSID2044896 Css NA 0.04025 mg/L PBTK NA 95% Rat Human +DTXSID2044898 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044898 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044898 Vd NA 1.184 L/kg 1compartment NA NA Human Human DTXSID2044898 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044898 TK.Half.Life NA 1.825 hours 1compartment NA NA Human Human -DTXSID2044898 Css NA 0.0721 mg/L 3compartmentss NA 50% Human Human -DTXSID2044898 Css NA 0.5034 mg/L 3compartmentss NA 95% Human Human -DTXSID2044898 Css NA 0.05296 mg/L PBTK NA 50% Human Human -DTXSID2044898 Css NA 0.3437 mg/L PBTK NA 95% Human Human -DTXSID2044898 Clint NA 29.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044898 Fup NA 0.2472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044898 Vd NA 1.111 L/kg 1compartment NA NA Rat Human +DTXSID2044898 TK.Half.Life NA 2.925 hours 1compartment NA NA Human Human +DTXSID2044898 Css NA 0.2514 mg/L 3compartmentss NA 50% Human Human +DTXSID2044898 Css NA 2.027 mg/L 3compartmentss NA 95% Human Human +DTXSID2044898 Css NA 0.1647 mg/L PBTK NA 50% Human Human +DTXSID2044898 Css NA 1.268 mg/L PBTK NA 95% Human Human +DTXSID2044898 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044898 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044898 Vd NA 0.9252 L/kg 1compartment NA NA Rat Human DTXSID2044898 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044898 TK.Half.Life NA 0.7265 hours 1compartment NA NA Rat Human -DTXSID2044898 Css NA 0.03953 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044898 Css NA 0.2138 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044898 Css NA 0.02779 mg/L PBTK NA 50% Rat Human -DTXSID2044898 Css NA 0.1401 mg/L PBTK NA 95% Rat Human -DTXSID2044925 Clint NA 0.8663 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044925 Fup NA 0.0294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044925 Vd NA 2.489 L/kg 1compartment NA NA Human Human -DTXSID2044925 Days.Css NA 101 Days PBTK NA NA Human Human -DTXSID2044925 TK.Half.Life NA 434 hours 1compartment NA NA Human Human -DTXSID2044925 Css NA 25.51 mg/L 3compartmentss NA 50% Human Human -DTXSID2044925 Css NA 114.8 mg/L 3compartmentss NA 95% Human Human -DTXSID2044925 Css NA 16.95 mg/L PBTK NA 50% Human Human -DTXSID2044925 Css NA 71.39 mg/L PBTK NA 95% Human Human -DTXSID2044925 Clint NA 0.8663 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044925 Fup NA 0.0294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044925 Vd NA 1.86 L/kg 1compartment NA NA Rat Human -DTXSID2044925 Days.Css NA 42 Days PBTK NA NA Rat Human -DTXSID2044925 TK.Half.Life NA 85.61 hours 1compartment NA NA Rat Human -DTXSID2044925 Css NA 11.31 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044925 Css NA 38.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044925 Css NA 7.16 mg/L PBTK NA 50% Rat Human -DTXSID2044925 Css NA 22.16 mg/L PBTK NA 95% Rat Human -DTXSID2044927 Clint NA 38.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044927 Fup NA 0.0347 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044927 Vd NA 3.016 L/kg 1compartment NA NA Human Human -DTXSID2044927 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2044927 TK.Half.Life NA 30.72 hours 1compartment NA NA Human Human -DTXSID2044927 Css NA 1.224 mg/L 3compartmentss NA 50% Human Human -DTXSID2044927 Css NA 7.676 mg/L 3compartmentss NA 95% Human Human -DTXSID2044927 Css NA 0.8414 mg/L PBTK NA 50% Human Human -DTXSID2044927 Css NA 5.07 mg/L PBTK NA 95% Human Human -DTXSID2044927 Clint NA 38.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044927 Fup NA 0.0347 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044927 Vd NA 2.261 L/kg 1compartment NA NA Rat Human -DTXSID2044927 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2044927 TK.Half.Life NA 5.03 hours 1compartment NA NA Rat Human -DTXSID2044927 Css NA 0.6842 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044927 Css NA 3.528 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044927 Css NA 0.449 mg/L PBTK NA 50% Rat Human -DTXSID2044927 Css NA 2.284 mg/L PBTK NA 95% Rat Human -DTXSID2044971 Clint NA 37.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044971 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044971 Vd NA 2.267 L/kg 1compartment NA NA Human Human -DTXSID2044971 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2044971 TK.Half.Life NA 17.66 hours 1compartment NA NA Human Human -DTXSID2044971 Css NA 1.129 mg/L 3compartmentss NA 50% Human Human -DTXSID2044971 Css NA 8.547 mg/L 3compartmentss NA 95% Human Human -DTXSID2044971 Css NA 0.7327 mg/L PBTK NA 50% Human Human -DTXSID2044971 Css NA 5.345 mg/L PBTK NA 95% Human Human -DTXSID2044971 Clint NA 37.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044971 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044971 Vd NA 1.687 L/kg 1compartment NA NA Rat Human -DTXSID2044971 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044971 TK.Half.Life NA 5.048 hours 1compartment NA NA Rat Human -DTXSID2044971 Css NA 0.6233 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044971 Css NA 3.927 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044971 Css NA 0.3818 mg/L PBTK NA 50% Rat Human -DTXSID2044971 Css NA 2.304 mg/L PBTK NA 95% Rat Human -DTXSID2044975 Clint NA 42.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044975 Fup NA 0.4769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044975 Vd NA 2.173 L/kg 1compartment NA NA Human Human -DTXSID2044975 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044975 TK.Half.Life NA 1.467 hours 1compartment NA NA Human Human -DTXSID2044975 Css NA 0.01652 mg/L 3compartmentss NA 50% Human Human -DTXSID2044975 Css NA 0.1538 mg/L 3compartmentss NA 95% Human Human -DTXSID2044975 Css NA 0.01703 mg/L PBTK NA 50% Human Human -DTXSID2044975 Css NA 0.1296 mg/L PBTK NA 95% Human Human -DTXSID2044975 Clint NA 42.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044975 Fup NA 0.4769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044975 Vd NA 2.16 L/kg 1compartment NA NA Rat Human +DTXSID2044898 TK.Half.Life NA 1.226 hours 1compartment NA NA Rat Human +DTXSID2044898 Css NA 0.03252 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044898 Css NA 0.1968 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044898 Css NA 0.02096 mg/L PBTK NA 50% Rat Human +DTXSID2044898 Css NA 0.1202 mg/L PBTK NA 95% Rat Human +DTXSID2044925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044925 Fup 0.00638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044925 Vd NA 1.709 L/kg 1compartment NA NA Human Human +DTXSID2044925 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2044925 TK.Half.Life NA 34.04 hours 1compartment NA NA Human Human +DTXSID2044925 Css NA 3.245 mg/L 3compartmentss NA 50% Human Human +DTXSID2044925 Css NA 27.83 mg/L 3compartmentss NA 95% Human Human +DTXSID2044925 Css NA 2.031 mg/L PBTK NA 50% Human Human +DTXSID2044925 Css NA 16.62 mg/L PBTK NA 95% Human Human +DTXSID2044925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044925 Fup 0.00638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044925 Vd NA 1.26 L/kg 1compartment NA NA Rat Human +DTXSID2044925 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2044925 TK.Half.Life NA 12.23 hours 1compartment NA NA Rat Human +DTXSID2044925 Css NA 0.4228 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044925 Css NA 3.055 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044925 Css NA 0.2563 mg/L PBTK NA 50% Rat Human +DTXSID2044925 Css NA 1.801 mg/L PBTK NA 95% Rat Human +DTXSID2044927 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044927 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044927 Vd NA 6.87 L/kg 1compartment NA NA Human Human +DTXSID2044927 Days.Css NA 40 Days PBTK NA NA Human Human +DTXSID2044927 TK.Half.Life NA 205.9 hours 1compartment NA NA Human Human +DTXSID2044927 Css NA 2.514 mg/L 3compartmentss NA 50% Human Human +DTXSID2044927 Css NA 15.17 mg/L 3compartmentss NA 95% Human Human +DTXSID2044927 Css NA 2.372 mg/L PBTK NA 50% Human Human +DTXSID2044927 Css NA 14.06 mg/L PBTK NA 95% Human Human +DTXSID2044927 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044927 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044927 Vd NA 5.32 L/kg 1compartment NA NA Rat Human +DTXSID2044927 Days.Css NA 23 Days PBTK NA NA Rat Human +DTXSID2044927 TK.Half.Life NA 28.17 hours 1compartment NA NA Rat Human +DTXSID2044927 Css NA 0.3198 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044927 Css NA 1.545 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044927 Css NA 0.3072 mg/L PBTK NA 50% Rat Human +DTXSID2044927 Css NA 1.509 mg/L PBTK NA 95% Rat Human +DTXSID2044971 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044971 Fup 0.00791 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044971 Vd NA 2.655 L/kg 1compartment NA NA Human Human +DTXSID2044971 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID2044971 TK.Half.Life NA 54.97 hours 1compartment NA NA Human Human +DTXSID2044971 Css NA 2.877 mg/L 3compartmentss NA 50% Human Human +DTXSID2044971 Css NA 21.86 mg/L 3compartmentss NA 95% Human Human +DTXSID2044971 Css NA 1.911 mg/L PBTK NA 50% Human Human +DTXSID2044971 Css NA 14.02 mg/L PBTK NA 95% Human Human +DTXSID2044971 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044971 Fup 0.00791 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044971 Vd NA 1.98 L/kg 1compartment NA NA Rat Human +DTXSID2044971 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID2044971 TK.Half.Life NA 12.02 hours 1compartment NA NA Rat Human +DTXSID2044971 Css NA 0.3736 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044971 Css NA 2.256 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044971 Css NA 0.2439 mg/L PBTK NA 50% Rat Human +DTXSID2044971 Css NA 1.44 mg/L PBTK NA 95% Rat Human +DTXSID2044975 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044975 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044975 Vd NA 1.454 L/kg 1compartment NA NA Human Human +DTXSID2044975 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2044975 TK.Half.Life NA 19.24 hours 1compartment NA NA Human Human +DTXSID2044975 Css NA 1.184 mg/L 3compartmentss NA 50% Human Human +DTXSID2044975 Css NA 6.928 mg/L 3compartmentss NA 95% Human Human +DTXSID2044975 Css NA 1.082 mg/L PBTK NA 50% Human Human +DTXSID2044975 Css NA 4.681 mg/L PBTK NA 95% Human Human +DTXSID2044975 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044975 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044975 Vd NA 1.444 L/kg 1compartment NA NA Rat Human DTXSID2044975 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044975 TK.Half.Life NA 0.7229 hours 1compartment NA NA Rat Human -DTXSID2044975 Css NA 0.008587 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044975 Css NA 0.07124 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044975 Css NA 0.008821 mg/L PBTK NA 50% Rat Human -DTXSID2044975 Css NA 0.05521 mg/L PBTK NA 95% Rat Human -DTXSID2044979 Clint NA 0.5915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044979 Fup NA 0.3388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2044979 Vd NA 0.6385 L/kg 1compartment NA NA Human Human +DTXSID2044975 TK.Half.Life NA 6.515 hours 1compartment NA NA Rat Human +DTXSID2044975 Css NA 0.07396 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044975 Css NA 0.3658 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044975 Css NA 0.06785 mg/L PBTK NA 50% Rat Human +DTXSID2044975 Css NA 0.2415 mg/L PBTK NA 95% Rat Human +DTXSID2044979 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044979 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2044979 Vd NA 0.5768 L/kg 1compartment NA NA Human Human DTXSID2044979 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2044979 TK.Half.Life NA 6.33 hours 1compartment NA NA Human Human -DTXSID2044979 Css NA 1.085 mg/L 3compartmentss NA 50% Human Human -DTXSID2044979 Css NA 4.886 mg/L 3compartmentss NA 95% Human Human -DTXSID2044979 Css NA 0.7942 mg/L PBTK NA 50% Human Human -DTXSID2044979 Css NA 3.114 mg/L PBTK NA 95% Human Human -DTXSID2044979 Clint NA 0.5915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044979 Fup NA 0.3388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2044979 Vd NA 0.61 L/kg 1compartment NA NA Rat Human +DTXSID2044979 TK.Half.Life NA 1.543 hours 1compartment NA NA Human Human +DTXSID2044979 Css NA 0.2395 mg/L 3compartmentss NA 50% Human Human +DTXSID2044979 Css NA 1.546 mg/L 3compartmentss NA 95% Human Human +DTXSID2044979 Css NA 0.1678 mg/L PBTK NA 50% Human Human +DTXSID2044979 Css NA 0.9987 mg/L PBTK NA 95% Human Human +DTXSID2044979 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044979 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2044979 Vd NA 0.5504 L/kg 1compartment NA NA Rat Human DTXSID2044979 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2044979 TK.Half.Life NA 2.712 hours 1compartment NA NA Rat Human -DTXSID2044979 Css NA 0.3992 mg/L 3compartmentss NA 50% Rat Human -DTXSID2044979 Css NA 1.509 mg/L 3compartmentss NA 95% Rat Human -DTXSID2044979 Css NA 0.2788 mg/L PBTK NA 50% Rat Human -DTXSID2044979 Css NA 0.8901 mg/L PBTK NA 95% Rat Human -DTXSID2045072 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045072 Fup NA 0.0263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045072 Vd NA 0.2559 L/kg 1compartment NA NA Human Human -DTXSID2045072 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID2045072 TK.Half.Life NA 62.96 hours 1compartment NA NA Human Human -DTXSID2045072 Css NA 42.02 mg/L 3compartmentss NA 50% Human Human -DTXSID2045072 Css NA 253.4 mg/L 3compartmentss NA 95% Human Human -DTXSID2045072 Css NA 25.18 mg/L PBTK NA 50% Human Human -DTXSID2045072 Css NA 147.8 mg/L PBTK NA 95% Human Human -DTXSID2045072 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045072 Fup NA 0.0263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045072 Vd NA 0.25 L/kg 1compartment NA NA Rat Human -DTXSID2045072 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2045072 TK.Half.Life NA 20.96 hours 1compartment NA NA Rat Human -DTXSID2045072 Css NA 11.92 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045072 Css NA 61.28 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045072 Css NA 6.66 mg/L PBTK NA 50% Rat Human -DTXSID2045072 Css NA 33.32 mg/L PBTK NA 95% Rat Human -DTXSID2045076 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045076 Fup NA 0.2848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045076 Vd NA 0.3143 L/kg 1compartment NA NA Human Human +DTXSID2044979 TK.Half.Life NA 0.8411 hours 1compartment NA NA Rat Human +DTXSID2044979 Css NA 0.02844 mg/L 3compartmentss NA 50% Rat Human +DTXSID2044979 Css NA 0.1306 mg/L 3compartmentss NA 95% Rat Human +DTXSID2044979 Css NA 0.01976 mg/L PBTK NA 50% Rat Human +DTXSID2044979 Css NA 0.08183 mg/L PBTK NA 95% Rat Human +DTXSID2045072 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045072 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045072 Vd NA 0.398 L/kg 1compartment NA NA Human Human +DTXSID2045072 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2045072 TK.Half.Life NA 18.93 hours 1compartment NA NA Human Human +DTXSID2045072 Css NA 6.634 mg/L 3compartmentss NA 50% Human Human +DTXSID2045072 Css NA 30.79 mg/L 3compartmentss NA 95% Human Human +DTXSID2045072 Css NA 4.3 mg/L PBTK NA 50% Human Human +DTXSID2045072 Css NA 18.49 mg/L PBTK NA 95% Human Human +DTXSID2045072 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045072 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045072 Vd NA 0.3965 L/kg 1compartment NA NA Rat Human +DTXSID2045072 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045072 TK.Half.Life NA 6.43 hours 1compartment NA NA Rat Human +DTXSID2045072 Css NA 0.4296 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045072 Css NA 1.704 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045072 Css NA 0.2717 mg/L PBTK NA 50% Rat Human +DTXSID2045072 Css NA 0.9877 mg/L PBTK NA 95% Rat Human +DTXSID2045076 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045076 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045076 Vd NA 0.3951 L/kg 1compartment NA NA Human Human DTXSID2045076 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045076 TK.Half.Life NA 7.141 hours 1compartment NA NA Human Human -DTXSID2045076 Css NA 2.827 mg/L 3compartmentss NA 50% Human Human -DTXSID2045076 Css NA 10.72 mg/L 3compartmentss NA 95% Human Human -DTXSID2045076 Css NA 1.853 mg/L PBTK NA 50% Human Human -DTXSID2045076 Css NA 6.492 mg/L PBTK NA 95% Human Human -DTXSID2045076 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045076 Fup NA 0.2848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045076 Vd NA 0.3234 L/kg 1compartment NA NA Rat Human +DTXSID2045076 TK.Half.Life NA 5.668 hours 1compartment NA NA Human Human +DTXSID2045076 Css NA 0.9098 mg/L 3compartmentss NA 50% Human Human +DTXSID2045076 Css NA 4.583 mg/L 3compartmentss NA 95% Human Human +DTXSID2045076 Css NA 0.6391 mg/L PBTK NA 50% Human Human +DTXSID2045076 Css NA 2.832 mg/L PBTK NA 95% Human Human +DTXSID2045076 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045076 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045076 Vd NA 0.4073 L/kg 1compartment NA NA Rat Human DTXSID2045076 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045076 TK.Half.Life NA 2.503 hours 1compartment NA NA Rat Human -DTXSID2045076 Css NA 0.7936 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045076 Css NA 2.517 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045076 Css NA 0.4889 mg/L PBTK NA 50% Rat Human -DTXSID2045076 Css NA 1.425 mg/L PBTK NA 95% Rat Human +DTXSID2045076 TK.Half.Life NA 1.991 hours 1compartment NA NA Rat Human +DTXSID2045076 Css NA 0.005009 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045076 Css NA 0.02455 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045076 Css NA 0.003328 mg/L PBTK NA 50% Rat Human +DTXSID2045076 Css NA 0.01454 mg/L PBTK NA 95% Rat Human DTXSID2045078 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045078 Fup NA 0.7335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045078 Vd NA 0.5476 L/kg 1compartment NA NA Human Human +DTXSID2045078 Vd NA 0.6192 L/kg 1compartment NA NA Human Human DTXSID2045078 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045078 TK.Half.Life NA 4.83 hours 1compartment NA NA Human Human -DTXSID2045078 Css NA 1.101 mg/L 3compartmentss NA 50% Human Human -DTXSID2045078 Css NA 6.861 mg/L 3compartmentss NA 95% Human Human -DTXSID2045078 Css NA 0.8551 mg/L PBTK NA 50% Human Human -DTXSID2045078 Css NA 4.32 mg/L PBTK NA 95% Human Human +DTXSID2045078 TK.Half.Life NA 5.462 hours 1compartment NA NA Human Human +DTXSID2045078 Css NA 0.9124 mg/L 3compartmentss NA 50% Human Human +DTXSID2045078 Css NA 5.696 mg/L 3compartmentss NA 95% Human Human +DTXSID2045078 Css NA 0.7322 mg/L PBTK NA 50% Human Human +DTXSID2045078 Css NA 3.686 mg/L PBTK NA 95% Human Human DTXSID2045078 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045078 Fup NA 0.7335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045078 Vd NA 0.5882 L/kg 1compartment NA NA Rat Human +DTXSID2045078 Vd NA 0.649 L/kg 1compartment NA NA Rat Human DTXSID2045078 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045078 TK.Half.Life NA 1.768 hours 1compartment NA NA Rat Human -DTXSID2045078 Css NA 0.2865 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045078 Css NA 1.726 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045078 Css NA 0.2141 mg/L PBTK NA 50% Rat Human -DTXSID2045078 Css NA 1.008 mg/L PBTK NA 95% Rat Human -DTXSID2045101 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045101 Fup NA 0.4803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045101 Vd NA 0.8801 L/kg 1compartment NA NA Human Human -DTXSID2045101 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2045101 TK.Half.Life NA 12.22 hours 1compartment NA NA Human Human -DTXSID2045101 Css NA 1.476 mg/L 3compartmentss NA 50% Human Human -DTXSID2045101 Css NA 7.316 mg/L 3compartmentss NA 95% Human Human -DTXSID2045101 Css NA 1.179 mg/L PBTK NA 50% Human Human -DTXSID2045101 Css NA 4.765 mg/L PBTK NA 95% Human Human -DTXSID2045101 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045101 Fup NA 0.4803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045101 Vd NA 0.8266 L/kg 1compartment NA NA Rat Human +DTXSID2045078 TK.Half.Life NA 1.951 hours 1compartment NA NA Rat Human +DTXSID2045078 Css NA 0.01746 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045078 Css NA 0.1372 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045078 Css NA 0.01339 mg/L PBTK NA 50% Rat Human +DTXSID2045078 Css NA 0.08618 mg/L PBTK NA 95% Rat Human +DTXSID2045101 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045101 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045101 Vd NA 0.5037 L/kg 1compartment NA NA Human Human +DTXSID2045101 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045101 TK.Half.Life NA 0.9328 hours 1compartment NA NA Human Human +DTXSID2045101 Css NA 0.1454 mg/L 3compartmentss NA 50% Human Human +DTXSID2045101 Css NA 1.046 mg/L 3compartmentss NA 95% Human Human +DTXSID2045101 Css NA 0.1062 mg/L PBTK NA 50% Human Human +DTXSID2045101 Css NA 0.6778 mg/L PBTK NA 95% Human Human +DTXSID2045101 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045101 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045101 Vd NA 0.5252 L/kg 1compartment NA NA Rat Human DTXSID2045101 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045101 TK.Half.Life NA 3.823 hours 1compartment NA NA Rat Human -DTXSID2045101 Css NA 0.397 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045101 Css NA 1.754 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045101 Css NA 0.305 mg/L PBTK NA 50% Rat Human -DTXSID2045101 Css NA 1.062 mg/L PBTK NA 95% Rat Human -DTXSID2045103 Clint NA 11.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045103 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045103 Vd NA 8.7 L/kg 1compartment NA NA Human Human +DTXSID2045101 TK.Half.Life NA 0.5357 hours 1compartment NA NA Rat Human +DTXSID2045101 Css NA 0.01686 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045101 Css NA 0.09176 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045101 Css NA 0.01225 mg/L PBTK NA 50% Rat Human +DTXSID2045101 Css NA 0.05686 mg/L PBTK NA 95% Rat Human +DTXSID2045103 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045103 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045103 Vd NA 4.218 L/kg 1compartment NA NA Human Human DTXSID2045103 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045103 TK.Half.Life NA 4.021 hours 1compartment NA NA Human Human -DTXSID2045103 Css NA 0.01422 mg/L 3compartmentss NA 50% Human Human -DTXSID2045103 Css NA 0.2362 mg/L 3compartmentss NA 95% Human Human -DTXSID2045103 Css NA 0.03202 mg/L PBTK NA 50% Human Human -DTXSID2045103 Css NA 0.3217 mg/L PBTK NA 95% Human Human -DTXSID2045103 Clint NA 11.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045103 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045103 Vd NA 8.964 L/kg 1compartment NA NA Rat Human +DTXSID2045103 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human +DTXSID2045103 Css NA 0.07855 mg/L 3compartmentss NA 50% Human Human +DTXSID2045103 Css NA 0.6842 mg/L 3compartmentss NA 95% Human Human +DTXSID2045103 Css NA 0.1082 mg/L PBTK NA 50% Human Human +DTXSID2045103 Css NA 0.6593 mg/L PBTK NA 95% Human Human +DTXSID2045103 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045103 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045103 Vd NA 4.288 L/kg 1compartment NA NA Rat Human DTXSID2045103 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045103 TK.Half.Life NA 2.276 hours 1compartment NA NA Rat Human -DTXSID2045103 Css NA 0.006548 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045103 Css NA 0.09047 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045103 Css NA 0.01584 mg/L PBTK NA 50% Rat Human -DTXSID2045103 Css NA 0.1133 mg/L PBTK NA 95% Rat Human -DTXSID2045105 Clint NA 8.785 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045105 Fup NA 0.0584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045105 Vd NA 3.04 L/kg 1compartment NA NA Human Human +DTXSID2045103 TK.Half.Life NA 3.997 hours 1compartment NA NA Rat Human +DTXSID2045103 Css NA 0.00878 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045103 Css NA 0.05898 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045103 Css NA 0.01282 mg/L PBTK NA 50% Rat Human +DTXSID2045103 Css NA 0.05585 mg/L PBTK NA 95% Rat Human +DTXSID2045105 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045105 Fup 0.0779 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045105 Vd NA 3.7 L/kg 1compartment NA NA Human Human DTXSID2045105 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045105 TK.Half.Life NA 8.794 hours 1compartment NA NA Human Human -DTXSID2045105 Css NA 0.2844 mg/L 3compartmentss NA 50% Human Human -DTXSID2045105 Css NA 2.395 mg/L 3compartmentss NA 95% Human Human -DTXSID2045105 Css NA 0.244 mg/L PBTK NA 50% Human Human -DTXSID2045105 Css NA 1.769 mg/L PBTK NA 95% Human Human -DTXSID2045105 Clint NA 8.785 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045105 Fup NA 0.0584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045105 Vd NA 2.812 L/kg 1compartment NA NA Rat Human +DTXSID2045105 TK.Half.Life NA 4.621 hours 1compartment NA NA Human Human +DTXSID2045105 Css NA 0.07159 mg/L 3compartmentss NA 50% Human Human +DTXSID2045105 Css NA 0.579 mg/L 3compartmentss NA 95% Human Human +DTXSID2045105 Css NA 0.06634 mg/L PBTK NA 50% Human Human +DTXSID2045105 Css NA 0.4664 mg/L PBTK NA 95% Human Human +DTXSID2045105 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045105 Fup 0.0779 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045105 Vd NA 3.352 L/kg 1compartment NA NA Rat Human DTXSID2045105 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045105 TK.Half.Life NA 4.214 hours 1compartment NA NA Rat Human -DTXSID2045105 Css NA 0.1573 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045105 Css NA 1.044 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045105 Css NA 0.1313 mg/L PBTK NA 50% Rat Human -DTXSID2045105 Css NA 0.7541 mg/L PBTK NA 95% Rat Human +DTXSID2045105 TK.Half.Life NA 1.832 hours 1compartment NA NA Rat Human +DTXSID2045105 Css NA 0.009118 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045105 Css NA 0.06326 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045105 Css NA 0.008609 mg/L PBTK NA 50% Rat Human +DTXSID2045105 Css NA 0.05106 mg/L PBTK NA 95% Rat Human DTXSID2045107 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045107 Fup NA 0.6044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045107 Vd NA 0.5777 L/kg 1compartment NA NA Human Human +DTXSID2045107 Vd NA 0.5472 L/kg 1compartment NA NA Human Human DTXSID2045107 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045107 TK.Half.Life NA 6.183 hours 1compartment NA NA Human Human -DTXSID2045107 Css NA 1.258 mg/L 3compartmentss NA 50% Human Human -DTXSID2045107 Css NA 8.681 mg/L 3compartmentss NA 95% Human Human -DTXSID2045107 Css NA 0.9816 mg/L PBTK NA 50% Human Human -DTXSID2045107 Css NA 5.412 mg/L PBTK NA 95% Human Human +DTXSID2045107 TK.Half.Life NA 5.859 hours 1compartment NA NA Human Human +DTXSID2045107 Css NA 1.077 mg/L 3compartmentss NA 50% Human Human +DTXSID2045107 Css NA 7.355 mg/L 3compartmentss NA 95% Human Human +DTXSID2045107 Css NA 0.833 mg/L PBTK NA 50% Human Human +DTXSID2045107 Css NA 4.531 mg/L PBTK NA 95% Human Human DTXSID2045107 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045107 Fup NA 0.6044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045107 Vd NA 0.6057 L/kg 1compartment NA NA Rat Human +DTXSID2045107 Vd NA 0.5792 L/kg 1compartment NA NA Rat Human DTXSID2045107 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045107 TK.Half.Life NA 2.21 hours 1compartment NA NA Rat Human -DTXSID2045107 Css NA 0.3314 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045107 Css NA 2.018 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045107 Css NA 0.2466 mg/L PBTK NA 50% Rat Human -DTXSID2045107 Css NA 1.176 mg/L PBTK NA 95% Rat Human -DTXSID2045109 Clint NA 22.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045109 Fup NA 0.0812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045109 Vd NA 2.14 L/kg 1compartment NA NA Human Human +DTXSID2045107 TK.Half.Life NA 2.113 hours 1compartment NA NA Rat Human +DTXSID2045107 Css NA 0.02124 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045107 Css NA 0.1731 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045107 Css NA 0.01549 mg/L PBTK NA 50% Rat Human +DTXSID2045107 Css NA 0.1077 mg/L PBTK NA 95% Rat Human +DTXSID2045109 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045109 Fup 0.0702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045109 Vd NA 1.711 L/kg 1compartment NA NA Human Human DTXSID2045109 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045109 TK.Half.Life NA 2.54 hours 1compartment NA NA Human Human -DTXSID2045109 Css NA 0.07482 mg/L 3compartmentss NA 50% Human Human -DTXSID2045109 Css NA 0.7452 mg/L 3compartmentss NA 95% Human Human -DTXSID2045109 Css NA 0.06686 mg/L PBTK NA 50% Human Human -DTXSID2045109 Css NA 0.5472 mg/L PBTK NA 95% Human Human -DTXSID2045109 Clint NA 22.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045109 Fup NA 0.0812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045109 Vd NA 2.089 L/kg 1compartment NA NA Rat Human +DTXSID2045109 TK.Half.Life NA 6.551 hours 1compartment NA NA Human Human +DTXSID2045109 Css NA 0.4175 mg/L 3compartmentss NA 50% Human Human +DTXSID2045109 Css NA 3.324 mg/L 3compartmentss NA 95% Human Human +DTXSID2045109 Css NA 0.3362 mg/L PBTK NA 50% Human Human +DTXSID2045109 Css NA 2.328 mg/L PBTK NA 95% Human Human +DTXSID2045109 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045109 Fup 0.0702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045109 Vd NA 1.668 L/kg 1compartment NA NA Rat Human DTXSID2045109 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045109 TK.Half.Life NA 1.391 hours 1compartment NA NA Rat Human -DTXSID2045109 Css NA 0.04166 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045109 Css NA 0.3349 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045109 Css NA 0.03598 mg/L PBTK NA 50% Rat Human -DTXSID2045109 Css NA 0.237 mg/L PBTK NA 95% Rat Human +DTXSID2045109 TK.Half.Life NA 4.014 hours 1compartment NA NA Rat Human +DTXSID2045109 Css NA 0.05266 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045109 Css NA 0.332 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045109 Css NA 0.04242 mg/L PBTK NA 50% Rat Human +DTXSID2045109 Css NA 0.2275 mg/L PBTK NA 95% Rat Human DTXSID2045151 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045151 Fup NA 0.9035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045151 Vd NA 1.928 L/kg 1compartment NA NA Human Human -DTXSID2045151 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2045151 TK.Half.Life NA 13.81 hours 1compartment NA NA Human Human -DTXSID2045151 Css NA 0.7274 mg/L 3compartmentss NA 50% Human Human -DTXSID2045151 Css NA 3.069 mg/L 3compartmentss NA 95% Human Human -DTXSID2045151 Css NA 0.7369 mg/L PBTK NA 50% Human Human -DTXSID2045151 Css NA 2.369 mg/L PBTK NA 95% Human Human +DTXSID2045151 Vd NA 0.6859 L/kg 1compartment NA NA Human Human +DTXSID2045151 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045151 TK.Half.Life NA 4.912 hours 1compartment NA NA Human Human +DTXSID2045151 Css NA 0.7706 mg/L 3compartmentss NA 50% Human Human +DTXSID2045151 Css NA 2.942 mg/L 3compartmentss NA 95% Human Human +DTXSID2045151 Css NA 0.6303 mg/L PBTK NA 50% Human Human +DTXSID2045151 Css NA 2.027 mg/L PBTK NA 95% Human Human DTXSID2045151 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045151 Fup NA 0.9035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045151 Vd NA 1.966 L/kg 1compartment NA NA Rat Human +DTXSID2045151 Vd NA 0.7285 L/kg 1compartment NA NA Rat Human DTXSID2045151 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045151 TK.Half.Life NA 4.797 hours 1compartment NA NA Rat Human -DTXSID2045151 Css NA 0.1835 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045151 Css NA 0.7386 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045151 Css NA 0.1851 mg/L PBTK NA 50% Rat Human -DTXSID2045151 Css NA 0.5218 mg/L PBTK NA 95% Rat Human -DTXSID2045153 Clint NA 4.219 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045153 Fup NA 0.2899 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045153 Vd NA 0.5058 L/kg 1compartment NA NA Human Human +DTXSID2045151 TK.Half.Life NA 1.778 hours 1compartment NA NA Rat Human +DTXSID2045151 Css NA 0.01375 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045151 Css NA 0.07762 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045151 Css NA 0.01082 mg/L PBTK NA 50% Rat Human +DTXSID2045151 Css NA 0.05403 mg/L PBTK NA 95% Rat Human +DTXSID2045153 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045153 Fup 0.502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045153 Vd NA 0.7617 L/kg 1compartment NA NA Human Human DTXSID2045153 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045153 TK.Half.Life NA 1.721 hours 1compartment NA NA Human Human -DTXSID2045153 Css NA 0.3482 mg/L 3compartmentss NA 50% Human Human -DTXSID2045153 Css NA 1.923 mg/L 3compartmentss NA 95% Human Human -DTXSID2045153 Css NA 0.2422 mg/L PBTK NA 50% Human Human -DTXSID2045153 Css NA 1.224 mg/L PBTK NA 95% Human Human -DTXSID2045153 Clint NA 4.219 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045153 Fup NA 0.2899 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045153 Vd NA 0.4995 L/kg 1compartment NA NA Rat Human +DTXSID2045153 TK.Half.Life NA 0.7537 hours 1compartment NA NA Human Human +DTXSID2045153 Css NA 0.03814 mg/L 3compartmentss NA 50% Human Human +DTXSID2045153 Css NA 0.3407 mg/L 3compartmentss NA 95% Human Human +DTXSID2045153 Css NA 0.02957 mg/L PBTK NA 50% Human Human +DTXSID2045153 Css NA 0.2353 mg/L PBTK NA 95% Human Human +DTXSID2045153 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045153 Fup 0.502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045153 Vd NA 0.7395 L/kg 1compartment NA NA Rat Human DTXSID2045153 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045153 TK.Half.Life NA 0.9669 hours 1compartment NA NA Rat Human -DTXSID2045153 Css NA 0.1709 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045153 Css NA 0.7238 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045153 Css NA 0.1145 mg/L PBTK NA 50% Rat Human -DTXSID2045153 Css NA 0.4319 mg/L PBTK NA 95% Rat Human -DTXSID2045157 Clint NA 343.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045157 Fup NA 0.2364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045157 Vd NA 1.128 L/kg 1compartment NA NA Human Human +DTXSID2045153 TK.Half.Life NA 0.3687 hours 1compartment NA NA Rat Human +DTXSID2045153 Css NA 0.004697 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045153 Css NA 0.03461 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045153 Css NA 0.003691 mg/L PBTK NA 50% Rat Human +DTXSID2045153 Css NA 0.02357 mg/L PBTK NA 95% Rat Human +DTXSID2045157 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045157 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045157 Vd NA 0.9669 L/kg 1compartment NA NA Human Human DTXSID2045157 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045157 TK.Half.Life NA 0.9181 hours 1compartment NA NA Human Human -DTXSID2045157 Css NA 0.006262 mg/L 3compartmentss NA 50% Human Human -DTXSID2045157 Css NA 0.04727 mg/L 3compartmentss NA 95% Human Human -DTXSID2045157 Css NA 0.004552 mg/L PBTK NA 50% Human Human -DTXSID2045157 Css NA 0.03186 mg/L PBTK NA 95% Human Human -DTXSID2045157 Clint NA 343.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045157 Fup NA 0.2364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045157 Vd NA 0.9297 L/kg 1compartment NA NA Rat Human +DTXSID2045157 TK.Half.Life NA 3.25 hours 1compartment NA NA Human Human +DTXSID2045157 Css NA 0.3222 mg/L 3compartmentss NA 50% Human Human +DTXSID2045157 Css NA 1.953 mg/L 3compartmentss NA 95% Human Human +DTXSID2045157 Css NA 0.2278 mg/L PBTK NA 50% Human Human +DTXSID2045157 Css NA 1.281 mg/L PBTK NA 95% Human Human +DTXSID2045157 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045157 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045157 Vd NA 0.8098 L/kg 1compartment NA NA Rat Human DTXSID2045157 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045157 TK.Half.Life NA 0.337 hours 1compartment NA NA Rat Human -DTXSID2045157 Css NA 0.003554 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045157 Css NA 0.0215 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045157 Css NA 0.00245 mg/L PBTK NA 50% Rat Human -DTXSID2045157 Css NA 0.01403 mg/L PBTK NA 95% Rat Human +DTXSID2045157 TK.Half.Life NA 1.513 hours 1compartment NA NA Rat Human +DTXSID2045157 Css NA 0.03841 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045157 Css NA 0.1693 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045157 Css NA 0.02689 mg/L PBTK NA 50% Rat Human +DTXSID2045157 Css NA 0.108 mg/L PBTK NA 95% Rat Human DTXSID2045232 Clint NA 23.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045232 Fup NA 0.0057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045232 Vd NA 1.219 L/kg 1compartment NA NA Human Human -DTXSID2045232 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2045232 TK.Half.Life NA 25.52 hours 1compartment NA NA Human Human -DTXSID2045232 Css NA 3.645 mg/L 3compartmentss NA 50% Human Human -DTXSID2045232 Css NA 33.29 mg/L 3compartmentss NA 95% Human Human -DTXSID2045232 Css NA 2.224 mg/L PBTK NA 50% Human Human -DTXSID2045232 Css NA 19.64 mg/L PBTK NA 95% Human Human +DTXSID2045232 Vd NA 0.384 L/kg 1compartment NA NA Human Human +DTXSID2045232 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2045232 TK.Half.Life NA 9.928 hours 1compartment NA NA Human Human +DTXSID2045232 Css NA 4.714 mg/L 3compartmentss NA 50% Human Human +DTXSID2045232 Css NA 46.55 mg/L 3compartmentss NA 95% Human Human +DTXSID2045232 Css NA 2.766 mg/L PBTK NA 50% Human Human +DTXSID2045232 Css NA 27.34 mg/L PBTK NA 95% Human Human DTXSID2045232 Clint NA 23.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045232 Fup NA 0.0057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045232 Vd NA 0.8949 L/kg 1compartment NA NA Rat Human -DTXSID2045232 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2045232 TK.Half.Life NA 10.65 hours 1compartment NA NA Rat Human -DTXSID2045232 Css NA 2.088 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045232 Css NA 15.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045232 Css NA 1.186 mg/L PBTK NA 50% Rat Human -DTXSID2045232 Css NA 8.419 mg/L PBTK NA 95% Rat Human +DTXSID2045232 Vd NA 0.2996 L/kg 1compartment NA NA Rat Human +DTXSID2045232 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045232 TK.Half.Life NA 5.157 hours 1compartment NA NA Rat Human +DTXSID2045232 Css NA 0.6164 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045232 Css NA 4.924 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045232 Css NA 0.349 mg/L PBTK NA 50% Rat Human +DTXSID2045232 Css NA 2.768 mg/L PBTK NA 95% Rat Human DTXSID2045236 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045236 Fup NA 0.1798 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045236 Vd NA 0.2531 L/kg 1compartment NA NA Human Human +DTXSID2045236 Vd NA 0.2236 L/kg 1compartment NA NA Human Human DTXSID2045236 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045236 TK.Half.Life NA 9.108 hours 1compartment NA NA Human Human -DTXSID2045236 Css NA 4.829 mg/L 3compartmentss NA 50% Human Human -DTXSID2045236 Css NA 17.31 mg/L 3compartmentss NA 95% Human Human -DTXSID2045236 Css NA 3.006 mg/L PBTK NA 50% Human Human -DTXSID2045236 Css NA 10.38 mg/L PBTK NA 95% Human Human +DTXSID2045236 TK.Half.Life NA 8.047 hours 1compartment NA NA Human Human +DTXSID2045236 Css NA 4.166 mg/L 3compartmentss NA 50% Human Human +DTXSID2045236 Css NA 15.16 mg/L 3compartmentss NA 95% Human Human +DTXSID2045236 Css NA 2.555 mg/L PBTK NA 50% Human Human +DTXSID2045236 Css NA 8.886 mg/L PBTK NA 95% Human Human DTXSID2045236 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045236 Fup NA 0.1798 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045236 Vd NA 0.2575 L/kg 1compartment NA NA Rat Human +DTXSID2045236 Vd NA 0.2322 L/kg 1compartment NA NA Rat Human DTXSID2045236 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045236 TK.Half.Life NA 3.158 hours 1compartment NA NA Rat Human -DTXSID2045236 Css NA 1.347 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045236 Css NA 4.001 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045236 Css NA 0.7889 mg/L PBTK NA 50% Rat Human -DTXSID2045236 Css NA 2.226 mg/L PBTK NA 95% Rat Human -DTXSID2045238 Clint NA 4.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045238 Fup NA 0.7706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045238 Vd NA 0.4713 L/kg 1compartment NA NA Human Human +DTXSID2045236 TK.Half.Life NA 2.847 hours 1compartment NA NA Rat Human +DTXSID2045236 Css NA 0.07433 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045236 Css NA 0.4211 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045236 Css NA 0.04357 mg/L PBTK NA 50% Rat Human +DTXSID2045236 Css NA 0.2438 mg/L PBTK NA 95% Rat Human +DTXSID2045238 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045238 Fup 0.586 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045238 Vd NA 0.4093 L/kg 1compartment NA NA Human Human DTXSID2045238 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045238 TK.Half.Life NA 0.6952 hours 1compartment NA NA Human Human -DTXSID2045238 Css NA 0.1322 mg/L 3compartmentss NA 50% Human Human -DTXSID2045238 Css NA 1.028 mg/L 3compartmentss NA 95% Human Human -DTXSID2045238 Css NA 0.09621 mg/L PBTK NA 50% Human Human -DTXSID2045238 Css NA 0.6566 mg/L PBTK NA 95% Human Human -DTXSID2045238 Clint NA 4.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045238 Fup NA 0.7706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045238 Vd NA 0.4938 L/kg 1compartment NA NA Rat Human +DTXSID2045238 TK.Half.Life NA 4.519 hours 1compartment NA NA Human Human +DTXSID2045238 Css NA 0.7632 mg/L 3compartmentss NA 50% Human Human +DTXSID2045238 Css NA 4.993 mg/L 3compartmentss NA 95% Human Human +DTXSID2045238 Css NA 0.5445 mg/L PBTK NA 50% Human Human +DTXSID2045238 Css NA 3.06 mg/L PBTK NA 95% Human Human +DTXSID2045238 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045238 Fup 0.586 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045238 Vd NA 0.4276 L/kg 1compartment NA NA Rat Human DTXSID2045238 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045238 TK.Half.Life NA 0.3823 hours 1compartment NA NA Rat Human -DTXSID2045238 Css NA 0.06247 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045238 Css NA 0.4216 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045238 Css NA 0.04424 mg/L PBTK NA 50% Rat Human -DTXSID2045238 Css NA 0.2479 mg/L PBTK NA 95% Rat Human -DTXSID2045280 Clint NA 55.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045280 Fup NA 0.2123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045280 Vd NA 2.657 L/kg 1compartment NA NA Human Human +DTXSID2045238 TK.Half.Life NA 1.609 hours 1compartment NA NA Rat Human +DTXSID2045238 Css NA 0.004081 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045238 Css NA 0.02651 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045238 Css NA 0.002784 mg/L PBTK NA 50% Rat Human +DTXSID2045238 Css NA 0.01537 mg/L PBTK NA 95% Rat Human +DTXSID2045280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045280 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045280 Vd NA 2.636 L/kg 1compartment NA NA Human Human DTXSID2045280 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045280 TK.Half.Life NA 2.086 hours 1compartment NA NA Human Human -DTXSID2045280 Css NA 0.02333 mg/L 3compartmentss NA 50% Human Human -DTXSID2045280 Css NA 0.1933 mg/L 3compartmentss NA 95% Human Human -DTXSID2045280 Css NA 0.02392 mg/L PBTK NA 50% Human Human -DTXSID2045280 Css NA 0.1655 mg/L PBTK NA 95% Human Human -DTXSID2045280 Clint NA 55.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045280 Fup NA 0.2123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045280 Vd NA 2.664 L/kg 1compartment NA NA Rat Human +DTXSID2045280 TK.Half.Life NA 3.385 hours 1compartment NA NA Human Human +DTXSID2045280 Css NA 0.06553 mg/L 3compartmentss NA 50% Human Human +DTXSID2045280 Css NA 0.5932 mg/L 3compartmentss NA 95% Human Human +DTXSID2045280 Css NA 0.06537 mg/L PBTK NA 50% Human Human +DTXSID2045280 Css NA 0.5012 mg/L PBTK NA 95% Human Human +DTXSID2045280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045280 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045280 Vd NA 2.64 L/kg 1compartment NA NA Rat Human DTXSID2045280 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045280 TK.Half.Life NA 1.086 hours 1compartment NA NA Rat Human -DTXSID2045280 Css NA 0.01246 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045280 Css NA 0.08347 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045280 Css NA 0.01263 mg/L PBTK NA 50% Rat Human -DTXSID2045280 Css NA 0.06899 mg/L PBTK NA 95% Rat Human -DTXSID2045315 Clint NA 9.237 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045315 Fup NA 0.0589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045315 Vd NA 3.084 L/kg 1compartment NA NA Human Human -DTXSID2045315 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID2045315 TK.Half.Life NA 117.5 hours 1compartment NA NA Human Human -DTXSID2045315 Css NA 4.686 mg/L 3compartmentss NA 50% Human Human -DTXSID2045315 Css NA 28.43 mg/L 3compartmentss NA 95% Human Human -DTXSID2045315 Css NA 3.257 mg/L PBTK NA 50% Human Human -DTXSID2045315 Css NA 19.02 mg/L PBTK NA 95% Human Human -DTXSID2045315 Clint NA 9.237 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045315 Fup NA 0.0589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045315 Vd NA 2.318 L/kg 1compartment NA NA Rat Human -DTXSID2045315 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID2045315 TK.Half.Life NA 16.78 hours 1compartment NA NA Rat Human -DTXSID2045315 Css NA 2.604 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045315 Css NA 12.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045315 Css NA 1.732 mg/L PBTK NA 50% Rat Human -DTXSID2045315 Css NA 8.033 mg/L PBTK NA 95% Rat Human -DTXSID2045361 Clint NA 11.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045361 Fup NA 0.1236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045361 Vd NA 2.439 L/kg 1compartment NA NA Human Human -DTXSID2045361 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2045361 TK.Half.Life NA 14.5 hours 1compartment NA NA Human Human -DTXSID2045361 Css NA 0.717 mg/L 3compartmentss NA 50% Human Human -DTXSID2045361 Css NA 4.476 mg/L 3compartmentss NA 95% Human Human -DTXSID2045361 Css NA 0.4954 mg/L PBTK NA 50% Human Human -DTXSID2045361 Css NA 2.989 mg/L PBTK NA 95% Human Human -DTXSID2045361 Clint NA 11.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045361 Fup NA 0.1236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045361 Vd NA 1.851 L/kg 1compartment NA NA Rat Human -DTXSID2045361 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045361 TK.Half.Life NA 3.903 hours 1compartment NA NA Rat Human -DTXSID2045361 Css NA 0.3882 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045361 Css NA 1.824 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045361 Css NA 0.2582 mg/L PBTK NA 50% Rat Human -DTXSID2045361 Css NA 1.158 mg/L PBTK NA 95% Rat Human -DTXSID2045365 Clint NA 1.429 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045365 Fup NA 0.1556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045365 Vd NA 0.5063 L/kg 1compartment NA NA Human Human -DTXSID2045365 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045365 TK.Half.Life NA 6.49 hours 1compartment NA NA Human Human -DTXSID2045365 Css NA 1.762 mg/L 3compartmentss NA 50% Human Human -DTXSID2045365 Css NA 9.338 mg/L 3compartmentss NA 95% Human Human -DTXSID2045365 Css NA 1.141 mg/L PBTK NA 50% Human Human -DTXSID2045365 Css NA 5.614 mg/L PBTK NA 95% Human Human -DTXSID2045365 Clint NA 1.429 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045365 Fup NA 0.1556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045365 Vd NA 0.443 L/kg 1compartment NA NA Rat Human +DTXSID2045280 TK.Half.Life NA 1.953 hours 1compartment NA NA Rat Human +DTXSID2045280 Css NA 0.008162 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045280 Css NA 0.05577 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045280 Css NA 0.008408 mg/L PBTK NA 50% Rat Human +DTXSID2045280 Css NA 0.04696 mg/L PBTK NA 95% Rat Human +DTXSID2045315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045315 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045315 Vd NA 0.9614 L/kg 1compartment NA NA Human Human +DTXSID2045315 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045315 TK.Half.Life NA 1.205 hours 1compartment NA NA Human Human +DTXSID2045315 Css NA 0.06162 mg/L 3compartmentss NA 50% Human Human +DTXSID2045315 Css NA 0.5029 mg/L 3compartmentss NA 95% Human Human +DTXSID2045315 Css NA 0.04676 mg/L PBTK NA 50% Human Human +DTXSID2045315 Css NA 0.3436 mg/L PBTK NA 95% Human Human +DTXSID2045315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045315 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045315 Vd NA 0.962 L/kg 1compartment NA NA Rat Human +DTXSID2045315 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045315 TK.Half.Life NA 0.6442 hours 1compartment NA NA Rat Human +DTXSID2045315 Css NA 0.007867 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045315 Css NA 0.04596 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045315 Css NA 0.005936 mg/L PBTK NA 50% Rat Human +DTXSID2045315 Css NA 0.03129 mg/L PBTK NA 95% Rat Human +DTXSID2045361 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045361 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045361 Vd NA 2.764 L/kg 1compartment NA NA Human Human +DTXSID2045361 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2045361 TK.Half.Life NA 23.14 hours 1compartment NA NA Human Human +DTXSID2045361 Css NA 0.8935 mg/L 3compartmentss NA 50% Human Human +DTXSID2045361 Css NA 4.829 mg/L 3compartmentss NA 95% Human Human +DTXSID2045361 Css NA 0.651 mg/L PBTK NA 50% Human Human +DTXSID2045361 Css NA 3.317 mg/L PBTK NA 95% Human Human +DTXSID2045361 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045361 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045361 Vd NA 2.106 L/kg 1compartment NA NA Rat Human +DTXSID2045361 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2045361 TK.Half.Life NA 4.93 hours 1compartment NA NA Rat Human +DTXSID2045361 Css NA 0.1071 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045361 Css NA 0.4159 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045361 Css NA 0.07817 mg/L PBTK NA 50% Rat Human +DTXSID2045361 Css NA 0.2914 mg/L PBTK NA 95% Rat Human +DTXSID2045365 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045365 Fup 0.302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045365 Vd NA 0.717 L/kg 1compartment NA NA Human Human +DTXSID2045365 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2045365 TK.Half.Life NA 16.02 hours 1compartment NA NA Human Human +DTXSID2045365 Css NA 2.512 mg/L 3compartmentss NA 50% Human Human +DTXSID2045365 Css NA 9.803 mg/L 3compartmentss NA 95% Human Human +DTXSID2045365 Css NA 1.782 mg/L PBTK NA 50% Human Human +DTXSID2045365 Css NA 6.19 mg/L PBTK NA 95% Human Human +DTXSID2045365 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045365 Fup 0.302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045365 Vd NA 0.6278 L/kg 1compartment NA NA Rat Human DTXSID2045365 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045365 TK.Half.Life NA 2.941 hours 1compartment NA NA Rat Human -DTXSID2045365 Css NA 0.7786 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045365 Css NA 3.236 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045365 Css NA 0.4735 mg/L PBTK NA 50% Rat Human -DTXSID2045365 Css NA 1.818 mg/L PBTK NA 95% Rat Human -DTXSID2045367 Clint NA 18.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045367 Fup NA 0.0406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045367 Vd NA 2.985 L/kg 1compartment NA NA Human Human -DTXSID2045367 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID2045367 TK.Half.Life NA 51.08 hours 1compartment NA NA Human Human -DTXSID2045367 Css NA 2.164 mg/L 3compartmentss NA 50% Human Human -DTXSID2045367 Css NA 13.79 mg/L 3compartmentss NA 95% Human Human -DTXSID2045367 Css NA 1.493 mg/L PBTK NA 50% Human Human -DTXSID2045367 Css NA 9.169 mg/L PBTK NA 95% Human Human -DTXSID2045367 Clint NA 18.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045367 Fup NA 0.0406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045367 Vd NA 2.237 L/kg 1compartment NA NA Rat Human -DTXSID2045367 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2045367 TK.Half.Life NA 8.345 hours 1compartment NA NA Rat Human -DTXSID2045367 Css NA 1.211 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045367 Css NA 6.117 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045367 Css NA 0.7957 mg/L PBTK NA 50% Rat Human -DTXSID2045367 Css NA 3.918 mg/L PBTK NA 95% Rat Human +DTXSID2045365 TK.Half.Life NA 4.63 hours 1compartment NA NA Rat Human +DTXSID2045365 Css NA 0.1607 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045365 Css NA 0.5245 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045365 Css NA 0.1128 mg/L PBTK NA 50% Rat Human +DTXSID2045365 Css NA 0.3199 mg/L PBTK NA 95% Rat Human +DTXSID2045367 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045367 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045367 Vd NA 2.858 L/kg 1compartment NA NA Human Human +DTXSID2045367 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID2045367 TK.Half.Life NA 42.81 hours 1compartment NA NA Human Human +DTXSID2045367 Css NA 1.908 mg/L 3compartmentss NA 50% Human Human +DTXSID2045367 Css NA 13.31 mg/L 3compartmentss NA 95% Human Human +DTXSID2045367 Css NA 1.295 mg/L PBTK NA 50% Human Human +DTXSID2045367 Css NA 8.694 mg/L PBTK NA 95% Human Human +DTXSID2045367 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045367 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045367 Vd NA 2.139 L/kg 1compartment NA NA Rat Human +DTXSID2045367 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID2045367 TK.Half.Life NA 7.997 hours 1compartment NA NA Rat Human +DTXSID2045367 Css NA 0.249 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045367 Css NA 1.43 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045367 Css NA 0.1669 mg/L PBTK NA 50% Rat Human +DTXSID2045367 Css NA 0.9067 mg/L PBTK NA 95% Rat Human DTXSID2045440 Clint NA 708 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045440 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045440 Vd NA 29090 L/kg 1compartment NA NA Human Human -DTXSID2045440 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID2045440 TK.Half.Life NA 26760 hours 1compartment NA NA Human Human -DTXSID2045440 Css NA 1.381e-05 mg/L 3compartmentss NA 50% Human Human -DTXSID2045440 Css NA 8.557e-05 mg/L 3compartmentss NA 95% Human Human -DTXSID2045440 Css NA 0.07689 mg/L PBTK NA 50% Human Human -DTXSID2045440 Css NA 0.4358 mg/L PBTK NA 95% Human Human +DTXSID2045440 Vd NA 3.481 L/kg 1compartment NA NA Human Human +DTXSID2045440 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045440 TK.Half.Life NA 5.97 hours 1compartment NA NA Human Human +DTXSID2045440 Css NA 0.08542 mg/L 3compartmentss NA 50% Human Human +DTXSID2045440 Css NA 0.5259 mg/L 3compartmentss NA 95% Human Human +DTXSID2045440 Css NA 0.06115 mg/L PBTK NA 50% Human Human +DTXSID2045440 Css NA 0.375 mg/L PBTK NA 95% Human Human DTXSID2045440 Clint NA 708 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045440 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045440 Vd NA 27540 L/kg 1compartment NA NA Rat Human -DTXSID2045440 Days.Css NA 4925 Days PBTK NA NA Rat Human -DTXSID2045440 TK.Half.Life NA 4627 hours 1compartment NA NA Rat Human -DTXSID2045440 Css NA 7.009e-06 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045440 Css NA 2.955e-05 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045440 Css NA 0.04173 mg/L PBTK NA 50% Rat Human -DTXSID2045440 Css NA 0.1778 mg/L PBTK NA 95% Rat Human -DTXSID2045442 Clint NA 7.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045442 Fup NA 0.1784 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045442 Vd NA 3.638 L/kg 1compartment NA NA Human Human +DTXSID2045440 Vd NA 2.618 L/kg 1compartment NA NA Rat Human +DTXSID2045440 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045440 TK.Half.Life NA 1.352 hours 1compartment NA NA Rat Human +DTXSID2045440 Css NA 0.003163 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045440 Css NA 0.02267 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045440 Css NA 0.002196 mg/L PBTK NA 50% Rat Human +DTXSID2045440 Css NA 0.01564 mg/L PBTK NA 95% Rat Human +DTXSID2045442 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045442 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045442 Vd NA 3.076 L/kg 1compartment NA NA Human Human DTXSID2045442 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045442 TK.Half.Life NA 11.32 hours 1compartment NA NA Human Human -DTXSID2045442 Css NA 0.2354 mg/L 3compartmentss NA 50% Human Human -DTXSID2045442 Css NA 1.476 mg/L 3compartmentss NA 95% Human Human -DTXSID2045442 Css NA 0.2336 mg/L PBTK NA 50% Human Human -DTXSID2045442 Css NA 1.308 mg/L PBTK NA 95% Human Human -DTXSID2045442 Clint NA 7.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045442 Fup NA 0.1784 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045442 Vd NA 3.374 L/kg 1compartment NA NA Rat Human +DTXSID2045442 TK.Half.Life NA 12.08 hours 1compartment NA NA Human Human +DTXSID2045442 Css NA 0.351 mg/L 3compartmentss NA 50% Human Human +DTXSID2045442 Css NA 2.583 mg/L 3compartmentss NA 95% Human Human +DTXSID2045442 Css NA 0.3228 mg/L PBTK NA 50% Human Human +DTXSID2045442 Css NA 1.992 mg/L PBTK NA 95% Human Human +DTXSID2045442 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045442 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045442 Vd NA 2.913 L/kg 1compartment NA NA Rat Human DTXSID2045442 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045442 TK.Half.Life NA 4.844 hours 1compartment NA NA Rat Human -DTXSID2045442 Css NA 0.1192 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045442 Css NA 0.5914 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045442 Css NA 0.1176 mg/L PBTK NA 50% Rat Human -DTXSID2045442 Css NA 0.5105 mg/L PBTK NA 95% Rat Human -DTXSID2045444 Clint NA 20.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045444 Fup NA 0.2894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045444 Vd NA 2.099 L/kg 1compartment NA NA Human Human +DTXSID2045442 TK.Half.Life NA 6.017 hours 1compartment NA NA Rat Human +DTXSID2045442 Css NA 0.04232 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045442 Css NA 0.2373 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045442 Css NA 0.03932 mg/L PBTK NA 50% Rat Human +DTXSID2045442 Css NA 0.1729 mg/L PBTK NA 95% Rat Human +DTXSID2045444 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045444 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045444 Vd NA 2.564 L/kg 1compartment NA NA Human Human DTXSID2045444 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045444 TK.Half.Life NA 2.506 hours 1compartment NA NA Human Human -DTXSID2045444 Css NA 0.06196 mg/L 3compartmentss NA 50% Human Human -DTXSID2045444 Css NA 0.464 mg/L 3compartmentss NA 95% Human Human -DTXSID2045444 Css NA 0.05582 mg/L PBTK NA 50% Human Human -DTXSID2045444 Css NA 0.3553 mg/L PBTK NA 95% Human Human -DTXSID2045444 Clint NA 20.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045444 Fup NA 0.2894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045444 Vd NA 2.063 L/kg 1compartment NA NA Rat Human +DTXSID2045444 TK.Half.Life NA 4.79 hours 1compartment NA NA Human Human +DTXSID2045444 Css NA 0.1195 mg/L 3compartmentss NA 50% Human Human +DTXSID2045444 Css NA 0.9224 mg/L 3compartmentss NA 95% Human Human +DTXSID2045444 Css NA 0.1194 mg/L PBTK NA 50% Human Human +DTXSID2045444 Css NA 0.7445 mg/L PBTK NA 95% Human Human +DTXSID2045444 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045444 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045444 Vd NA 2.537 L/kg 1compartment NA NA Rat Human DTXSID2045444 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045444 TK.Half.Life NA 1.33 hours 1compartment NA NA Rat Human -DTXSID2045444 Css NA 0.03255 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045444 Css NA 0.1986 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045444 Css NA 0.02858 mg/L PBTK NA 50% Rat Human -DTXSID2045444 Css NA 0.147 mg/L PBTK NA 95% Rat Human -DTXSID2045448 Clint NA 144.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045448 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045448 Vd NA 0.4572 L/kg 1compartment NA NA Human Human -DTXSID2045448 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045448 TK.Half.Life NA 1.442 hours 1compartment NA NA Human Human -DTXSID2045448 Css NA 0.4174 mg/L 3compartmentss NA 50% Human Human -DTXSID2045448 Css NA 4.384 mg/L 3compartmentss NA 95% Human Human -DTXSID2045448 Css NA 0.2466 mg/L PBTK NA 50% Human Human -DTXSID2045448 Css NA 2.576 mg/L PBTK NA 95% Human Human -DTXSID2045448 Clint NA 144.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045448 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045448 Vd NA 0.3525 L/kg 1compartment NA NA Rat Human +DTXSID2045444 TK.Half.Life NA 2.632 hours 1compartment NA NA Rat Human +DTXSID2045444 Css NA 0.01356 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045444 Css NA 0.07923 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045444 Css NA 0.01414 mg/L PBTK NA 50% Rat Human +DTXSID2045444 Css NA 0.062 mg/L PBTK NA 95% Rat Human +DTXSID2045448 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045448 Fup 0.0306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045448 Vd NA 0.6636 L/kg 1compartment NA NA Human Human +DTXSID2045448 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2045448 TK.Half.Life NA 12.25 hours 1compartment NA NA Human Human +DTXSID2045448 Css NA 3.186 mg/L 3compartmentss NA 50% Human Human +DTXSID2045448 Css NA 26.53 mg/L 3compartmentss NA 95% Human Human +DTXSID2045448 Css NA 1.931 mg/L PBTK NA 50% Human Human +DTXSID2045448 Css NA 15.48 mg/L PBTK NA 95% Human Human +DTXSID2045448 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045448 Fup 0.0306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045448 Vd NA 0.5077 L/kg 1compartment NA NA Rat Human DTXSID2045448 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045448 TK.Half.Life NA 0.6743 hours 1compartment NA NA Rat Human -DTXSID2045448 Css NA 0.2448 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045448 Css NA 2.152 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045448 Css NA 0.1351 mg/L PBTK NA 50% Rat Human -DTXSID2045448 Css NA 1.175 mg/L PBTK NA 95% Rat Human -DTXSID2045490 Clint NA 9.635 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045490 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045490 Vd NA 2.454 L/kg 1compartment NA NA Human Human -DTXSID2045490 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID2045490 TK.Half.Life NA 71.08 hours 1compartment NA NA Human Human -DTXSID2045490 Css NA 4.407 mg/L 3compartmentss NA 50% Human Human -DTXSID2045490 Css NA 30.31 mg/L 3compartmentss NA 95% Human Human -DTXSID2045490 Css NA 2.904 mg/L PBTK NA 50% Human Human -DTXSID2045490 Css NA 19.16 mg/L PBTK NA 95% Human Human -DTXSID2045490 Clint NA 9.635 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045490 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045490 Vd NA 1.83 L/kg 1compartment NA NA Rat Human -DTXSID2045490 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID2045490 TK.Half.Life NA 17.63 hours 1compartment NA NA Rat Human -DTXSID2045490 Css NA 2.387 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045490 Css NA 13 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045490 Css NA 1.486 mg/L PBTK NA 50% Rat Human -DTXSID2045490 Css NA 7.875 mg/L PBTK NA 95% Rat Human -DTXSID2045492 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045492 Fup NA 0.3449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045492 Vd NA 0.4419 L/kg 1compartment NA NA Human Human +DTXSID2045448 TK.Half.Life NA 5.668 hours 1compartment NA NA Rat Human +DTXSID2045448 Css NA 0.3912 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045448 Css NA 2.521 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045448 Css NA 0.229 mg/L PBTK NA 50% Rat Human +DTXSID2045448 Css NA 1.427 mg/L PBTK NA 95% Rat Human +DTXSID2045490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045490 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045490 Vd NA 0.3581 L/kg 1compartment NA NA Human Human +DTXSID2045490 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045490 TK.Half.Life NA 0.767 hours 1compartment NA NA Human Human +DTXSID2045490 Css NA 0.2016 mg/L 3compartmentss NA 50% Human Human +DTXSID2045490 Css NA 1.709 mg/L 3compartmentss NA 95% Human Human +DTXSID2045490 Css NA 0.1275 mg/L PBTK NA 50% Human Human +DTXSID2045490 Css NA 1.044 mg/L PBTK NA 95% Human Human +DTXSID2045490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045490 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045490 Vd NA 0.3497 L/kg 1compartment NA NA Rat Human +DTXSID2045490 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045490 TK.Half.Life NA 0.4319 hours 1compartment NA NA Rat Human +DTXSID2045490 Css NA 0.02666 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045490 Css NA 0.1632 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045490 Css NA 0.01632 mg/L PBTK NA 50% Rat Human +DTXSID2045490 Css NA 0.09554 mg/L PBTK NA 95% Rat Human +DTXSID2045492 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045492 Fup 0.487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045492 Vd NA 0.5633 L/kg 1compartment NA NA Human Human DTXSID2045492 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045492 TK.Half.Life NA 8.305 hours 1compartment NA NA Human Human -DTXSID2045492 Css NA 2.23 mg/L 3compartmentss NA 50% Human Human -DTXSID2045492 Css NA 8.869 mg/L 3compartmentss NA 95% Human Human -DTXSID2045492 Css NA 1.549 mg/L PBTK NA 50% Human Human -DTXSID2045492 Css NA 5.539 mg/L PBTK NA 95% Human Human -DTXSID2045492 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045492 Fup NA 0.3449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045492 Vd NA 0.4438 L/kg 1compartment NA NA Rat Human +DTXSID2045492 TK.Half.Life NA 0.9544 hours 1compartment NA NA Human Human +DTXSID2045492 Css NA 0.06329 mg/L 3compartmentss NA 50% Human Human +DTXSID2045492 Css NA 0.5358 mg/L 3compartmentss NA 95% Human Human +DTXSID2045492 Css NA 0.04831 mg/L PBTK NA 50% Human Human +DTXSID2045492 Css NA 0.356 mg/L PBTK NA 95% Human Human +DTXSID2045492 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045492 Fup 0.487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045492 Vd NA 0.5795 L/kg 1compartment NA NA Rat Human DTXSID2045492 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045492 TK.Half.Life NA 2.837 hours 1compartment NA NA Rat Human -DTXSID2045492 Css NA 0.618 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045492 Css NA 2.101 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045492 Css NA 0.4064 mg/L PBTK NA 50% Rat Human -DTXSID2045492 Css NA 1.217 mg/L PBTK NA 95% Rat Human -DTXSID2045494 Clint NA 20.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045494 Fup NA 0.2054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045494 Vd NA 2.388 L/kg 1compartment NA NA Human Human +DTXSID2045492 TK.Half.Life NA 0.5386 hours 1compartment NA NA Rat Human +DTXSID2045492 Css NA 0.000569 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045492 Css NA 0.004672 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045492 Css NA 0.0004179 mg/L PBTK NA 50% Rat Human +DTXSID2045492 Css NA 0.002936 mg/L PBTK NA 95% Rat Human +DTXSID2045494 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045494 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045494 Vd NA 1.61 L/kg 1compartment NA NA Human Human DTXSID2045494 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045494 TK.Half.Life NA 2.76 hours 1compartment NA NA Human Human -DTXSID2045494 Css NA 0.05482 mg/L 3compartmentss NA 50% Human Human -DTXSID2045494 Css NA 0.445 mg/L 3compartmentss NA 95% Human Human -DTXSID2045494 Css NA 0.0575 mg/L PBTK NA 50% Human Human -DTXSID2045494 Css NA 0.3793 mg/L PBTK NA 95% Human Human -DTXSID2045494 Clint NA 20.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045494 Fup NA 0.2054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045494 Vd NA 2.36 L/kg 1compartment NA NA Rat Human +DTXSID2045494 TK.Half.Life NA 3.376 hours 1compartment NA NA Human Human +DTXSID2045494 Css NA 0.129 mg/L 3compartmentss NA 50% Human Human +DTXSID2045494 Css NA 0.8925 mg/L 3compartmentss NA 95% Human Human +DTXSID2045494 Css NA 0.1171 mg/L PBTK NA 50% Human Human +DTXSID2045494 Css NA 0.6765 mg/L PBTK NA 95% Human Human +DTXSID2045494 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045494 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045494 Vd NA 1.586 L/kg 1compartment NA NA Rat Human DTXSID2045494 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045494 TK.Half.Life NA 1.553 hours 1compartment NA NA Rat Human -DTXSID2045494 Css NA 0.02964 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045494 Css NA 0.1871 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045494 Css NA 0.03043 mg/L PBTK NA 50% Rat Human -DTXSID2045494 Css NA 0.1556 mg/L PBTK NA 95% Rat Human -DTXSID2045496 Clint NA 35.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045496 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045496 Vd NA 2.862 L/kg 1compartment NA NA Human Human +DTXSID2045494 TK.Half.Life NA 1.923 hours 1compartment NA NA Rat Human +DTXSID2045494 Css NA 0.005432 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045494 Css NA 0.04701 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045494 Css NA 0.005062 mg/L PBTK NA 50% Rat Human +DTXSID2045494 Css NA 0.0347 mg/L PBTK NA 95% Rat Human +DTXSID2045496 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045496 Fup 0.0328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045496 Vd NA 2.273 L/kg 1compartment NA NA Human Human DTXSID2045496 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045496 TK.Half.Life NA 7.361 hours 1compartment NA NA Human Human -DTXSID2045496 Css NA 0.2543 mg/L 3compartmentss NA 50% Human Human -DTXSID2045496 Css NA 1.927 mg/L 3compartmentss NA 95% Human Human -DTXSID2045496 Css NA 0.1811 mg/L PBTK NA 50% Human Human -DTXSID2045496 Css NA 1.269 mg/L PBTK NA 95% Human Human -DTXSID2045496 Clint NA 35.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045496 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045496 Vd NA 2.261 L/kg 1compartment NA NA Rat Human +DTXSID2045496 TK.Half.Life NA 8.262 hours 1compartment NA NA Human Human +DTXSID2045496 Css NA 0.432 mg/L 3compartmentss NA 50% Human Human +DTXSID2045496 Css NA 4.153 mg/L 3compartmentss NA 95% Human Human +DTXSID2045496 Css NA 0.3063 mg/L PBTK NA 50% Human Human +DTXSID2045496 Css NA 2.691 mg/L PBTK NA 95% Human Human +DTXSID2045496 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045496 Fup 0.0328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045496 Vd NA 1.927 L/kg 1compartment NA NA Rat Human DTXSID2045496 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045496 TK.Half.Life NA 2.092 hours 1compartment NA NA Rat Human -DTXSID2045496 Css NA 0.1416 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045496 Css NA 0.8887 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045496 Css NA 0.09618 mg/L PBTK NA 50% Rat Human -DTXSID2045496 Css NA 0.5564 mg/L PBTK NA 95% Rat Human -DTXSID2045498 Clint NA 40.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045498 Fup NA 0.0873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045498 Vd NA 2.551 L/kg 1compartment NA NA Human Human -DTXSID2045498 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045498 TK.Half.Life NA 7.27 hours 1compartment NA NA Human Human -DTXSID2045498 Css NA 0.2883 mg/L 3compartmentss NA 50% Human Human -DTXSID2045498 Css NA 2.049 mg/L 3compartmentss NA 95% Human Human -DTXSID2045498 Css NA 0.2017 mg/L PBTK NA 50% Human Human -DTXSID2045498 Css NA 1.336 mg/L PBTK NA 95% Human Human -DTXSID2045498 Clint NA 40.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045498 Fup NA 0.0873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045498 Vd NA 1.964 L/kg 1compartment NA NA Rat Human -DTXSID2045498 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045498 TK.Half.Life NA 2.09 hours 1compartment NA NA Rat Human -DTXSID2045498 Css NA 0.1616 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045498 Css NA 0.909 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045498 Css NA 0.1076 mg/L PBTK NA 50% Rat Human -DTXSID2045498 Css NA 0.5807 mg/L PBTK NA 95% Rat Human +DTXSID2045496 TK.Half.Life NA 3.49 hours 1compartment NA NA Rat Human +DTXSID2045496 Css NA 0.05622 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045496 Css NA 0.4174 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045496 Css NA 0.0393 mg/L PBTK NA 50% Rat Human +DTXSID2045496 Css NA 0.2688 mg/L PBTK NA 95% Rat Human +DTXSID2045498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045498 Fup 0.0288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045498 Vd NA 2.847 L/kg 1compartment NA NA Human Human +DTXSID2045498 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2045498 TK.Half.Life NA 37.49 hours 1compartment NA NA Human Human +DTXSID2045498 Css NA 1.669 mg/L 3compartmentss NA 50% Human Human +DTXSID2045498 Css NA 11.69 mg/L 3compartmentss NA 95% Human Human +DTXSID2045498 Css NA 1.136 mg/L PBTK NA 50% Human Human +DTXSID2045498 Css NA 7.765 mg/L PBTK NA 95% Human Human +DTXSID2045498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045498 Fup 0.0288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045498 Vd NA 2.143 L/kg 1compartment NA NA Rat Human +DTXSID2045498 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2045498 TK.Half.Life NA 7.386 hours 1compartment NA NA Rat Human +DTXSID2045498 Css NA 0.2168 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045498 Css NA 1.268 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045498 Css NA 0.1461 mg/L PBTK NA 50% Rat Human +DTXSID2045498 Css NA 0.8315 mg/L PBTK NA 95% Rat Human DTXSID2045521 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045521 Fup NA 0.9168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045521 Vd NA 0.4472 L/kg 1compartment NA NA Human Human DTXSID2045521 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2045521 TK.Half.Life NA 3.156 hours 1compartment NA NA Human Human -DTXSID2045521 Css NA 1 mg/L 3compartmentss NA 50% Human Human -DTXSID2045521 Css NA 3.453 mg/L 3compartmentss NA 95% Human Human -DTXSID2045521 Css NA 0.7361 mg/L PBTK NA 50% Human Human -DTXSID2045521 Css NA 2.252 mg/L PBTK NA 95% Human Human +DTXSID2045521 Css NA 0.5462 mg/L 3compartmentss NA 50% Human Human +DTXSID2045521 Css NA 2.006 mg/L 3compartmentss NA 95% Human Human +DTXSID2045521 Css NA 0.3994 mg/L PBTK NA 50% Human Human +DTXSID2045521 Css NA 1.321 mg/L PBTK NA 95% Human Human DTXSID2045521 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045521 Fup NA 0.9168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045521 Vd NA 0.4802 L/kg 1compartment NA NA Rat Human DTXSID2045521 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2045521 TK.Half.Life NA 1.155 hours 1compartment NA NA Rat Human -DTXSID2045521 Css NA 0.2608 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045521 Css NA 0.8386 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045521 Css NA 0.184 mg/L PBTK NA 50% Rat Human -DTXSID2045521 Css NA 0.5036 mg/L PBTK NA 95% Rat Human +DTXSID2045521 Css NA 0.002802 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045521 Css NA 0.01124 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045521 Css NA 0.001983 mg/L PBTK NA 50% Rat Human +DTXSID2045521 Css NA 0.007135 mg/L PBTK NA 95% Rat Human DTXSID2045523 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045523 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2045523 Vd NA 0.7363 L/kg 1compartment NA NA Human Human +DTXSID2045523 Vd NA 1.171 L/kg 1compartment NA NA Human Human DTXSID2045523 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045523 TK.Half.Life NA 4.764 hours 1compartment NA NA Human Human -DTXSID2045523 Css NA 0.839 mg/L 3compartmentss NA 50% Human Human -DTXSID2045523 Css NA 5.532 mg/L 3compartmentss NA 95% Human Human -DTXSID2045523 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID2045523 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID2045523 TK.Half.Life NA 7.797 hours 1compartment NA NA Human Human +DTXSID2045523 Css NA 0.6479 mg/L 3compartmentss NA 50% Human Human +DTXSID2045523 Css NA 4.668 mg/L 3compartmentss NA 95% Human Human +DTXSID2045523 Css NA 0.595 mg/L PBTK NA 50% Human Human +DTXSID2045523 Css NA 3.218 mg/L PBTK NA 95% Human Human DTXSID2045523 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045523 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2045523 Vd NA 0.7815 L/kg 1compartment NA NA Rat Human +DTXSID2045523 Vd NA 1.142 L/kg 1compartment NA NA Rat Human DTXSID2045523 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045523 TK.Half.Life NA 1.723 hours 1compartment NA NA Rat Human -DTXSID2045523 Css NA 0.2108 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045523 Css NA 1.312 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045523 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID2045523 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID2045527 Clint NA 4.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045527 Fup NA 0.6738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045527 Vd NA 0.4734 L/kg 1compartment NA NA Human Human +DTXSID2045523 TK.Half.Life NA 2.535 hours 1compartment NA NA Rat Human +DTXSID2045523 Css NA 0.01185 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045523 Css NA 0.09006 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045523 Css NA 0.01067 mg/L PBTK NA 50% Rat Human +DTXSID2045523 Css NA 0.06314 mg/L PBTK NA 95% Rat Human +DTXSID2045527 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045527 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045527 Vd NA 0.7139 L/kg 1compartment NA NA Human Human DTXSID2045527 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045527 TK.Half.Life NA 0.7964 hours 1compartment NA NA Human Human -DTXSID2045527 Css NA 0.1553 mg/L 3compartmentss NA 50% Human Human -DTXSID2045527 Css NA 1.217 mg/L 3compartmentss NA 95% Human Human -DTXSID2045527 Css NA 0.1123 mg/L PBTK NA 50% Human Human -DTXSID2045527 Css NA 0.7884 mg/L PBTK NA 95% Human Human -DTXSID2045527 Clint NA 4.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045527 Fup NA 0.6738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045527 Vd NA 0.4889 L/kg 1compartment NA NA Rat Human +DTXSID2045527 TK.Half.Life NA 8.413 hours 1compartment NA NA Human Human +DTXSID2045527 Css NA 1.245 mg/L 3compartmentss NA 50% Human Human +DTXSID2045527 Css NA 8.249 mg/L 3compartmentss NA 95% Human Human +DTXSID2045527 Css NA 1.013 mg/L PBTK NA 50% Human Human +DTXSID2045527 Css NA 5.276 mg/L PBTK NA 95% Human Human +DTXSID2045527 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045527 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045527 Vd NA 0.7269 L/kg 1compartment NA NA Rat Human DTXSID2045527 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045527 TK.Half.Life NA 0.4381 hours 1compartment NA NA Rat Human -DTXSID2045527 Css NA 0.07235 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045527 Css NA 0.5126 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045527 Css NA 0.05098 mg/L PBTK NA 50% Rat Human -DTXSID2045527 Css NA 0.3009 mg/L PBTK NA 95% Rat Human -DTXSID2045529 Clint NA 22.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045529 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045529 Vd NA 2.859 L/kg 1compartment NA NA Human Human -DTXSID2045529 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID2045529 TK.Half.Life NA 50.74 hours 1compartment NA NA Human Human -DTXSID2045529 Css NA 2.37 mg/L 3compartmentss NA 50% Human Human -DTXSID2045529 Css NA 15.69 mg/L 3compartmentss NA 95% Human Human -DTXSID2045529 Css NA 1.602 mg/L PBTK NA 50% Human Human -DTXSID2045529 Css NA 10.08 mg/L PBTK NA 95% Human Human -DTXSID2045529 Clint NA 22.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045529 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045529 Vd NA 2.137 L/kg 1compartment NA NA Rat Human -DTXSID2045529 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID2045529 TK.Half.Life NA 9.387 hours 1compartment NA NA Rat Human -DTXSID2045529 Css NA 1.328 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045529 Css NA 7.258 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045529 Css NA 0.8568 mg/L PBTK NA 50% Rat Human -DTXSID2045529 Css NA 4.452 mg/L PBTK NA 95% Rat Human -DTXSID2045571 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045571 Fup NA 0.772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045571 Vd NA 3.935 L/kg 1compartment NA NA Human Human -DTXSID2045571 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2045571 TK.Half.Life NA 33.16 hours 1compartment NA NA Human Human -DTXSID2045571 Css NA 0.622 mg/L 3compartmentss NA 50% Human Human -DTXSID2045571 Css NA 5.299 mg/L 3compartmentss NA 95% Human Human -DTXSID2045571 Css NA 0.8361 mg/L PBTK NA 50% Human Human -DTXSID2045571 Css NA 4.043 mg/L PBTK NA 95% Human Human -DTXSID2045571 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045571 Fup NA 0.772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045571 Vd NA 4.019 L/kg 1compartment NA NA Rat Human -DTXSID2045571 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2045571 TK.Half.Life NA 11.49 hours 1compartment NA NA Rat Human -DTXSID2045571 Css NA 0.1545 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045571 Css NA 1.324 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045571 Css NA 0.2079 mg/L PBTK NA 50% Rat Human -DTXSID2045571 Css NA 0.9487 mg/L PBTK NA 95% Rat Human -DTXSID2045573 Clint NA 1.842 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045573 Fup NA 0.0499 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045573 Vd NA 0.3215 L/kg 1compartment NA NA Human Human -DTXSID2045573 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2045573 TK.Half.Life NA 10.42 hours 1compartment NA NA Human Human -DTXSID2045573 Css NA 5.363 mg/L 3compartmentss NA 50% Human Human -DTXSID2045573 Css NA 32.36 mg/L 3compartmentss NA 95% Human Human -DTXSID2045573 Css NA 3.341 mg/L PBTK NA 50% Human Human -DTXSID2045573 Css NA 19.38 mg/L PBTK NA 95% Human Human -DTXSID2045573 Clint NA 1.842 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045573 Fup NA 0.0499 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045573 Vd NA 0.3103 L/kg 1compartment NA NA Rat Human +DTXSID2045527 TK.Half.Life NA 2.92 hours 1compartment NA NA Rat Human +DTXSID2045527 Css NA 0.07626 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045527 Css NA 0.472 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045527 Css NA 0.06214 mg/L PBTK NA 50% Rat Human +DTXSID2045527 Css NA 0.2898 mg/L PBTK NA 95% Rat Human +DTXSID2045529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045529 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045529 Vd NA 0.2831 L/kg 1compartment NA NA Human Human +DTXSID2045529 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045529 TK.Half.Life NA 0.687 hours 1compartment NA NA Human Human +DTXSID2045529 Css NA 0.2562 mg/L 3compartmentss NA 50% Human Human +DTXSID2045529 Css NA 2.087 mg/L 3compartmentss NA 95% Human Human +DTXSID2045529 Css NA 0.1587 mg/L PBTK NA 50% Human Human +DTXSID2045529 Css NA 1.25 mg/L PBTK NA 95% Human Human +DTXSID2045529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045529 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045529 Vd NA 0.2859 L/kg 1compartment NA NA Rat Human +DTXSID2045529 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045529 TK.Half.Life NA 0.4073 hours 1compartment NA NA Rat Human +DTXSID2045529 Css NA 0.03342 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045529 Css NA 0.2139 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045529 Css NA 0.01994 mg/L PBTK NA 50% Rat Human +DTXSID2045529 Css NA 0.1224 mg/L PBTK NA 95% Rat Human +DTXSID2045571 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045571 Fup 0.659 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045571 Vd NA 1.558 L/kg 1compartment NA NA Human Human +DTXSID2045571 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2045571 TK.Half.Life NA 15.3 hours 1compartment NA NA Human Human +DTXSID2045571 Css NA 0.841 mg/L 3compartmentss NA 50% Human Human +DTXSID2045571 Css NA 6.377 mg/L 3compartmentss NA 95% Human Human +DTXSID2045571 Css NA 0.795 mg/L PBTK NA 50% Human Human +DTXSID2045571 Css NA 4.178 mg/L PBTK NA 95% Human Human +DTXSID2045571 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045571 Fup 0.659 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045571 Vd NA 1.582 L/kg 1compartment NA NA Rat Human +DTXSID2045571 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045571 TK.Half.Life NA 5.291 hours 1compartment NA NA Rat Human +DTXSID2045571 Css NA 0.02142 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045571 Css NA 0.1895 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045571 Css NA 0.02044 mg/L PBTK NA 50% Rat Human +DTXSID2045571 Css NA 0.1284 mg/L PBTK NA 95% Rat Human +DTXSID2045573 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045573 Fup 0.0761 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045573 Vd NA 0.3857 L/kg 1compartment NA NA Human Human +DTXSID2045573 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045573 TK.Half.Life NA 1.202 hours 1compartment NA NA Human Human +DTXSID2045573 Css NA 0.3271 mg/L 3compartmentss NA 50% Human Human +DTXSID2045573 Css NA 2.63 mg/L 3compartmentss NA 95% Human Human +DTXSID2045573 Css NA 0.2102 mg/L PBTK NA 50% Human Human +DTXSID2045573 Css NA 1.611 mg/L PBTK NA 95% Human Human +DTXSID2045573 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045573 Fup 0.0761 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045573 Vd NA 0.3733 L/kg 1compartment NA NA Rat Human DTXSID2045573 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045573 TK.Half.Life NA 5.554 hours 1compartment NA NA Rat Human -DTXSID2045573 Css NA 2.495 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045573 Css NA 12.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045573 Css NA 1.447 mg/L PBTK NA 50% Rat Human -DTXSID2045573 Css NA 6.609 mg/L PBTK NA 95% Rat Human -DTXSID2045575 Clint NA 13.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045575 Fup NA 0.4617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045575 Vd NA 4.143 L/kg 1compartment NA NA Human Human +DTXSID2045573 TK.Half.Life NA 0.7108 hours 1compartment NA NA Rat Human +DTXSID2045573 Css NA 0.01605 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045573 Css NA 0.1398 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045573 Css NA 0.009992 mg/L PBTK NA 50% Rat Human +DTXSID2045573 Css NA 0.08172 mg/L PBTK NA 95% Rat Human +DTXSID2045575 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045575 Fup 0.421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045575 Vd NA 1.372 L/kg 1compartment NA NA Human Human DTXSID2045575 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045575 TK.Half.Life NA 3.721 hours 1compartment NA NA Human Human -DTXSID2045575 Css NA 0.03681 mg/L 3compartmentss NA 50% Human Human -DTXSID2045575 Css NA 0.3662 mg/L 3compartmentss NA 95% Human Human -DTXSID2045575 Css NA 0.04987 mg/L PBTK NA 50% Human Human -DTXSID2045575 Css NA 0.3653 mg/L PBTK NA 95% Human Human -DTXSID2045575 Clint NA 13.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045575 Fup NA 0.4617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045575 Vd NA 4.224 L/kg 1compartment NA NA Rat Human +DTXSID2045575 TK.Half.Life NA 2.57 hours 1compartment NA NA Human Human +DTXSID2045575 Css NA 0.1345 mg/L 3compartmentss NA 50% Human Human +DTXSID2045575 Css NA 1.001 mg/L 3compartmentss NA 95% Human Human +DTXSID2045575 Css NA 0.1156 mg/L PBTK NA 50% Human Human +DTXSID2045575 Css NA 0.7078 mg/L PBTK NA 95% Human Human +DTXSID2045575 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045575 Fup 0.421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045575 Vd NA 1.382 L/kg 1compartment NA NA Rat Human DTXSID2045575 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045575 TK.Half.Life NA 2.133 hours 1compartment NA NA Rat Human -DTXSID2045575 Css NA 0.01854 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045575 Css NA 0.152 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045575 Css NA 0.02532 mg/L PBTK NA 50% Rat Human -DTXSID2045575 Css NA 0.1372 mg/L PBTK NA 95% Rat Human -DTXSID2045579 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045579 Fup NA 0.1656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045579 Vd NA 0.3056 L/kg 1compartment NA NA Human Human -DTXSID2045579 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2045579 TK.Half.Life NA 11.95 hours 1compartment NA NA Human Human -DTXSID2045579 Css NA 5.044 mg/L 3compartmentss NA 50% Human Human -DTXSID2045579 Css NA 17.64 mg/L 3compartmentss NA 95% Human Human -DTXSID2045579 Css NA 3.182 mg/L PBTK NA 50% Human Human -DTXSID2045579 Css NA 10.55 mg/L PBTK NA 95% Human Human -DTXSID2045579 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045579 Fup NA 0.1656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045579 Vd NA 0.303 L/kg 1compartment NA NA Rat Human +DTXSID2045575 TK.Half.Life NA 1.463 hours 1compartment NA NA Rat Human +DTXSID2045575 Css NA 0.01517 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045575 Css NA 0.08523 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045575 Css NA 0.0132 mg/L PBTK NA 50% Rat Human +DTXSID2045575 Css NA 0.05919 mg/L PBTK NA 95% Rat Human +DTXSID2045579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045579 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045579 Vd NA 0.3251 L/kg 1compartment NA NA Human Human +DTXSID2045579 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045579 TK.Half.Life NA 7.328 hours 1compartment NA NA Human Human +DTXSID2045579 Css NA 1.488 mg/L 3compartmentss NA 50% Human Human +DTXSID2045579 Css NA 6.133 mg/L 3compartmentss NA 95% Human Human +DTXSID2045579 Css NA 0.9789 mg/L PBTK NA 50% Human Human +DTXSID2045579 Css NA 3.711 mg/L PBTK NA 95% Human Human +DTXSID2045579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045579 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045579 Vd NA 0.334 L/kg 1compartment NA NA Rat Human DTXSID2045579 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045579 TK.Half.Life NA 4.035 hours 1compartment NA NA Rat Human -DTXSID2045579 Css NA 1.419 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045579 Css NA 4.091 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045579 Css NA 0.842 mg/L PBTK NA 50% Rat Human -DTXSID2045579 Css NA 2.289 mg/L PBTK NA 95% Rat Human -DTXSID2045600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045600 Fup NA 0.5941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045600 Vd NA 0.561 L/kg 1compartment NA NA Human Human +DTXSID2045579 TK.Half.Life NA 2.566 hours 1compartment NA NA Rat Human +DTXSID2045579 Css NA 0.0082 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045579 Css NA 0.03371 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045579 Css NA 0.005101 mg/L PBTK NA 50% Rat Human +DTXSID2045579 Css NA 0.01941 mg/L PBTK NA 95% Rat Human +DTXSID2045600 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045600 Fup 0.799 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045600 Vd NA 0.653 L/kg 1compartment NA NA Human Human DTXSID2045600 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045600 TK.Half.Life NA 6.112 hours 1compartment NA NA Human Human -DTXSID2045600 Css NA 1.287 mg/L 3compartmentss NA 50% Human Human -DTXSID2045600 Css NA 8.264 mg/L 3compartmentss NA 95% Human Human -DTXSID2045600 Css NA 0.985 mg/L PBTK NA 50% Human Human -DTXSID2045600 Css NA 5.212 mg/L PBTK NA 95% Human Human -DTXSID2045600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045600 Fup NA 0.5941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045600 Vd NA 0.588 L/kg 1compartment NA NA Rat Human +DTXSID2045600 TK.Half.Life NA 0.8006 hours 1compartment NA NA Human Human +DTXSID2045600 Css NA 0.04466 mg/L 3compartmentss NA 50% Human Human +DTXSID2045600 Css NA 0.414 mg/L 3compartmentss NA 95% Human Human +DTXSID2045600 Css NA 0.03516 mg/L PBTK NA 50% Human Human +DTXSID2045600 Css NA 0.287 mg/L PBTK NA 95% Human Human +DTXSID2045600 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045600 Fup 0.799 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045600 Vd NA 0.6883 L/kg 1compartment NA NA Rat Human DTXSID2045600 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045600 TK.Half.Life NA 2.183 hours 1compartment NA NA Rat Human -DTXSID2045600 Css NA 0.3399 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045600 Css NA 2.086 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045600 Css NA 0.2496 mg/L PBTK NA 50% Rat Human -DTXSID2045600 Css NA 1.21 mg/L PBTK NA 95% Rat Human -DTXSID2045602 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045602 Fup NA 0.1088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045602 Vd NA 0.7586 L/kg 1compartment NA NA Human Human -DTXSID2045602 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID2045602 TK.Half.Life NA 48.74 hours 1compartment NA NA Human Human -DTXSID2045602 Css NA 9.605 mg/L 3compartmentss NA 50% Human Human -DTXSID2045602 Css NA 42.71 mg/L 3compartmentss NA 95% Human Human -DTXSID2045602 Css NA 6.155 mg/L PBTK NA 50% Human Human -DTXSID2045602 Css NA 25.34 mg/L PBTK NA 95% Human Human -DTXSID2045602 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045602 Fup NA 0.1088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045602 Vd NA 0.6064 L/kg 1compartment NA NA Rat Human -DTXSID2045602 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2045602 TK.Half.Life NA 12.52 hours 1compartment NA NA Rat Human -DTXSID2045602 Css NA 2.676 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045602 Css NA 10.28 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045602 Css NA 1.612 mg/L PBTK NA 50% Rat Human -DTXSID2045602 Css NA 5.73 mg/L PBTK NA 95% Rat Human -DTXSID2045604 Clint NA 0.7402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045604 Fup NA 0.0317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045604 Vd NA 1.588 L/kg 1compartment NA NA Human Human -DTXSID2045604 Days.Css NA 37 Days PBTK NA NA Human Human -DTXSID2045604 TK.Half.Life NA 176.6 hours 1compartment NA NA Human Human -DTXSID2045604 Css NA 17.88 mg/L 3compartmentss NA 50% Human Human -DTXSID2045604 Css NA 94.58 mg/L 3compartmentss NA 95% Human Human -DTXSID2045604 Css NA 11.33 mg/L PBTK NA 50% Human Human -DTXSID2045604 Css NA 55.34 mg/L PBTK NA 95% Human Human -DTXSID2045604 Clint NA 0.7402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045604 Fup NA 0.0317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045604 Vd NA 1.186 L/kg 1compartment NA NA Rat Human -DTXSID2045604 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID2045604 TK.Half.Life NA 49.97 hours 1compartment NA NA Rat Human -DTXSID2045604 Css NA 7.342 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045604 Css NA 33.28 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045604 Css NA 4.38 mg/L PBTK NA 50% Rat Human -DTXSID2045604 Css NA 18.46 mg/L PBTK NA 95% Rat Human -DTXSID2045606 Clint NA 35.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2045600 TK.Half.Life NA 0.4426 hours 1compartment NA NA Rat Human +DTXSID2045600 Css NA 0.0003865 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045600 Css NA 0.003722 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045600 Css NA 0.0002993 mg/L PBTK NA 50% Rat Human +DTXSID2045600 Css NA 0.002404 mg/L PBTK NA 95% Rat Human +DTXSID2045602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045602 Fup 0.0686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045602 Vd NA 0.5671 L/kg 1compartment NA NA Human Human +DTXSID2045602 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045602 TK.Half.Life NA 5.063 hours 1compartment NA NA Human Human +DTXSID2045602 Css NA 1.404 mg/L 3compartmentss NA 50% Human Human +DTXSID2045602 Css NA 9.735 mg/L 3compartmentss NA 95% Human Human +DTXSID2045602 Css NA 0.8654 mg/L PBTK NA 50% Human Human +DTXSID2045602 Css NA 5.803 mg/L PBTK NA 95% Human Human +DTXSID2045602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045602 Fup 0.0686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045602 Vd NA 0.4571 L/kg 1compartment NA NA Rat Human +DTXSID2045602 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045602 TK.Half.Life NA 2.461 hours 1compartment NA NA Rat Human +DTXSID2045602 Css NA 0.1742 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045602 Css NA 0.8847 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045602 Css NA 0.1043 mg/L PBTK NA 50% Rat Human +DTXSID2045602 Css NA 0.5086 mg/L PBTK NA 95% Rat Human +DTXSID2045606 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2045606 Fup 0.83 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2045606 Vd NA 3.417 L/kg 1compartment NA NA Human Human +DTXSID2045606 Vd NA 3.478 L/kg 1compartment NA NA Human Human DTXSID2045606 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045606 TK.Half.Life NA 1.893 hours 1compartment NA NA Human Human -DTXSID2045606 Css NA 0.01366 mg/L 3compartmentss NA 50% Human Human -DTXSID2045606 Css NA 0.1514 mg/L 3compartmentss NA 95% Human Human -DTXSID2045606 Css NA 0.01434 mg/L PBTK NA 50% Human Human -DTXSID2045606 Css NA 0.1223 mg/L PBTK NA 95% Human Human +DTXSID2045606 TK.Half.Life NA 3.616 hours 1compartment NA NA Human Human +DTXSID2045606 Css NA 0.0589 mg/L 3compartmentss NA 50% Human Human +DTXSID2045606 Css NA 0.4185 mg/L 3compartmentss NA 95% Human Human +DTXSID2045606 Css NA 0.07026 mg/L PBTK NA 50% Human Human +DTXSID2045606 Css NA 0.5011 mg/L PBTK NA 95% Human Human DTXSID2045606 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID2045606 Fup 0.76 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID2045606 Vd NA 3.27 L/kg 1compartment NA NA Rat Rat +DTXSID2045606 Vd NA 3.3 L/kg 1compartment NA NA Rat Rat DTXSID2045606 Days.Css NA 1 Days PBTK NA NA Rat Rat -DTXSID2045606 TK.Half.Life NA 9.507 hours 1compartment NA NA Rat Rat -DTXSID2045606 Css NA 0.1919 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2045606 Css NA 1.49 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2045606 Css NA 0.2102 mg/L PBTK NA 50% Rat Rat -DTXSID2045606 Css NA 0.9817 mg/L PBTK NA 95% Rat Rat -DTXSID2045608 Clint NA 12.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045608 Fup NA 0.2712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045608 Vd NA 2.675 L/kg 1compartment NA NA Human Human +DTXSID2045606 TK.Half.Life NA 9.575 hours 1compartment NA NA Rat Rat +DTXSID2045606 Css NA 0.03907 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2045606 Css NA 0.1846 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2045606 Css NA 0.04855 mg/L PBTK NA 50% Rat Rat +DTXSID2045606 Css NA 0.2294 mg/L PBTK NA 95% Rat Rat +DTXSID2045608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045608 Fup 0.309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045608 Vd NA 2.868 L/kg 1compartment NA NA Human Human DTXSID2045608 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045608 TK.Half.Life NA 4.715 hours 1compartment NA NA Human Human -DTXSID2045608 Css NA 0.1164 mg/L 3compartmentss NA 50% Human Human -DTXSID2045608 Css NA 0.8378 mg/L 3compartmentss NA 95% Human Human -DTXSID2045608 Css NA 0.108 mg/L PBTK NA 50% Human Human -DTXSID2045608 Css NA 0.6511 mg/L PBTK NA 95% Human Human -DTXSID2045608 Clint NA 12.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045608 Fup NA 0.2712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045608 Vd NA 2.492 L/kg 1compartment NA NA Rat Human +DTXSID2045608 TK.Half.Life NA 7.465 hours 1compartment NA NA Human Human +DTXSID2045608 Css NA 0.1889 mg/L 3compartmentss NA 50% Human Human +DTXSID2045608 Css NA 1.256 mg/L 3compartmentss NA 95% Human Human +DTXSID2045608 Css NA 0.1802 mg/L PBTK NA 50% Human Human +DTXSID2045608 Css NA 1.023 mg/L PBTK NA 95% Human Human +DTXSID2045608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045608 Fup 0.309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045608 Vd NA 2.677 L/kg 1compartment NA NA Rat Human DTXSID2045608 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045608 TK.Half.Life NA 2.259 hours 1compartment NA NA Rat Human -DTXSID2045608 Css NA 0.06092 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045608 Css NA 0.3222 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045608 Css NA 0.05522 mg/L PBTK NA 50% Rat Human -DTXSID2045608 Css NA 0.2458 mg/L PBTK NA 95% Rat Human +DTXSID2045608 TK.Half.Life NA 3.504 hours 1compartment NA NA Rat Human +DTXSID2045608 Css NA 0.0219 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045608 Css NA 0.1081 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045608 Css NA 0.02157 mg/L PBTK NA 50% Rat Human +DTXSID2045608 Css NA 0.0857 mg/L PBTK NA 95% Rat Human DTXSID2045650 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045650 Fup NA 0.7933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2045650 Vd NA 0.5814 L/kg 1compartment NA NA Human Human DTXSID2045650 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2045650 TK.Half.Life NA 4.741 hours 1compartment NA NA Human Human -DTXSID2045650 Css NA 1.043 mg/L 3compartmentss NA 50% Human Human -DTXSID2045650 Css NA 6.073 mg/L 3compartmentss NA 95% Human Human -DTXSID2045650 Css NA 0.8218 mg/L PBTK NA 50% Human Human -DTXSID2045650 Css NA 3.843 mg/L PBTK NA 95% Human Human +DTXSID2045650 Css NA 0.875 mg/L 3compartmentss NA 50% Human Human +DTXSID2045650 Css NA 5.27 mg/L 3compartmentss NA 95% Human Human +DTXSID2045650 Css NA 0.6928 mg/L PBTK NA 50% Human Human +DTXSID2045650 Css NA 3.335 mg/L PBTK NA 95% Human Human DTXSID2045650 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045650 Fup NA 0.7933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2045650 Vd NA 0.6304 L/kg 1compartment NA NA Rat Human DTXSID2045650 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2045650 TK.Half.Life NA 1.752 hours 1compartment NA NA Rat Human -DTXSID2045650 Css NA 0.2678 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045650 Css NA 1.532 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045650 Css NA 0.2033 mg/L PBTK NA 50% Rat Human -DTXSID2045650 Css NA 0.9028 mg/L PBTK NA 95% Rat Human -DTXSID2045652 Clint NA 9.038 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045652 Fup NA 0.806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045652 Vd NA 2.128 L/kg 1compartment NA NA Human Human -DTXSID2045652 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045652 TK.Half.Life NA 1.95 hours 1compartment NA NA Human Human -DTXSID2045652 Css NA 0.05419 mg/L 3compartmentss NA 50% Human Human -DTXSID2045652 Css NA 0.515 mg/L 3compartmentss NA 95% Human Human -DTXSID2045652 Css NA 0.05438 mg/L PBTK NA 50% Human Human -DTXSID2045652 Css NA 0.4049 mg/L PBTK NA 95% Human Human -DTXSID2045652 Clint NA 9.038 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045652 Fup NA 0.806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045652 Vd NA 2.162 L/kg 1compartment NA NA Rat Human +DTXSID2045650 Css NA 0.01672 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045650 Css NA 0.1255 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045650 Css NA 0.01266 mg/L PBTK NA 50% Rat Human +DTXSID2045650 Css NA 0.07937 mg/L PBTK NA 95% Rat Human +DTXSID2045652 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045652 Fup 0.712 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045652 Vd NA 1.789 L/kg 1compartment NA NA Human Human +DTXSID2045652 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2045652 TK.Half.Life NA 16.26 hours 1compartment NA NA Human Human +DTXSID2045652 Css NA 0.766 mg/L 3compartmentss NA 50% Human Human +DTXSID2045652 Css NA 5.72 mg/L 3compartmentss NA 95% Human Human +DTXSID2045652 Css NA 0.7506 mg/L PBTK NA 50% Human Human +DTXSID2045652 Css NA 3.895 mg/L PBTK NA 95% Human Human +DTXSID2045652 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045652 Fup 0.712 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045652 Vd NA 1.816 L/kg 1compartment NA NA Rat Human DTXSID2045652 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045652 TK.Half.Life NA 1.057 hours 1compartment NA NA Rat Human -DTXSID2045652 Css NA 0.02624 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045652 Css NA 0.2131 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045652 Css NA 0.02654 mg/L PBTK NA 50% Rat Human -DTXSID2045652 Css NA 0.1518 mg/L PBTK NA 95% Rat Human -DTXSID2045654 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045654 Fup NA 0.711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045654 Vd NA 0.573 L/kg 1compartment NA NA Human Human +DTXSID2045652 TK.Half.Life NA 5.626 hours 1compartment NA NA Rat Human +DTXSID2045652 Css NA 0.01972 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045652 Css NA 0.1703 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045652 Css NA 0.01874 mg/L PBTK NA 50% Rat Human +DTXSID2045652 Css NA 0.1166 mg/L PBTK NA 95% Rat Human +DTXSID2045654 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045654 Fup 0.535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045654 Vd NA 0.474 L/kg 1compartment NA NA Human Human DTXSID2045654 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045654 TK.Half.Life NA 5.231 hours 1compartment NA NA Human Human -DTXSID2045654 Css NA 1.144 mg/L 3compartmentss NA 50% Human Human -DTXSID2045654 Css NA 6.963 mg/L 3compartmentss NA 95% Human Human -DTXSID2045654 Css NA 0.877 mg/L PBTK NA 50% Human Human -DTXSID2045654 Css NA 4.352 mg/L PBTK NA 95% Human Human -DTXSID2045654 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045654 Fup NA 0.711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045654 Vd NA 0.5775 L/kg 1compartment NA NA Rat Human +DTXSID2045654 TK.Half.Life NA 5.743 hours 1compartment NA NA Human Human +DTXSID2045654 Css NA 1.423 mg/L 3compartmentss NA 50% Human Human +DTXSID2045654 Css NA 8.089 mg/L 3compartmentss NA 95% Human Human +DTXSID2045654 Css NA 1.036 mg/L PBTK NA 50% Human Human +DTXSID2045654 Css NA 4.995 mg/L PBTK NA 95% Human Human +DTXSID2045654 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045654 Fup 0.535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045654 Vd NA 0.4797 L/kg 1compartment NA NA Rat Human DTXSID2045654 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045654 TK.Half.Life NA 1.792 hours 1compartment NA NA Rat Human -DTXSID2045654 Css NA 0.2992 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045654 Css NA 1.856 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045654 Css NA 0.2196 mg/L PBTK NA 50% Rat Human -DTXSID2045654 Css NA 1.076 mg/L PBTK NA 95% Rat Human +DTXSID2045654 TK.Half.Life NA 1.978 hours 1compartment NA NA Rat Human +DTXSID2045654 Css NA 0.08858 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045654 Css NA 0.4501 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045654 Css NA 0.06352 mg/L PBTK NA 50% Rat Human +DTXSID2045654 Css NA 0.2685 mg/L PBTK NA 95% Rat Human DTXSID2045656 Clint 56.72 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID2045656 Fup NA 0.097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045656 Vd NA 2.973 L/kg 1compartment NA NA Human Human +DTXSID2045656 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045656 Vd NA 3.391 L/kg 1compartment NA NA Human Human DTXSID2045656 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045656 TK.Half.Life NA 4.268 hours 1compartment NA NA Human Human -DTXSID2045656 Css NA 0.09676 mg/L 3compartmentss NA 50% Human Human -DTXSID2045656 Css NA 0.7319 mg/L 3compartmentss NA 95% Human Human -DTXSID2045656 Css NA 0.07602 mg/L PBTK NA 50% Human Human -DTXSID2045656 Css NA 0.5326 mg/L PBTK NA 95% Human Human +DTXSID2045656 TK.Half.Life NA 4.827 hours 1compartment NA NA Human Human +DTXSID2045656 Css NA 0.08344 mg/L 3compartmentss NA 50% Human Human +DTXSID2045656 Css NA 0.6061 mg/L 3compartmentss NA 95% Human Human +DTXSID2045656 Css NA 0.0678 mg/L PBTK NA 50% Human Human +DTXSID2045656 Css NA 0.452 mg/L PBTK NA 95% Human Human DTXSID2045656 Clint 56.72 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID2045656 Fup NA 0.097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045656 Vd NA 2.537 L/kg 1compartment NA NA Rat Human +DTXSID2045656 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045656 Vd NA 2.838 L/kg 1compartment NA NA Rat Human DTXSID2045656 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045656 TK.Half.Life NA 1.56 hours 1compartment NA NA Rat Human -DTXSID2045656 Css NA 0.05326 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045656 Css NA 0.3249 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045656 Css NA 0.04068 mg/L PBTK NA 50% Rat Human -DTXSID2045656 Css NA 0.2309 mg/L PBTK NA 95% Rat Human -DTXSID2045658 Clint NA 1.903 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045658 Fup NA 0.7729 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045658 Vd NA 2.637 L/kg 1compartment NA NA Human Human -DTXSID2045658 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045658 TK.Half.Life NA 5.986 hours 1compartment NA NA Human Human -DTXSID2045658 Css NA 0.1915 mg/L 3compartmentss NA 50% Human Human -DTXSID2045658 Css NA 1.602 mg/L 3compartmentss NA 95% Human Human -DTXSID2045658 Css NA 0.2088 mg/L PBTK NA 50% Human Human -DTXSID2045658 Css NA 1.186 mg/L PBTK NA 95% Human Human -DTXSID2045658 Clint NA 1.903 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045658 Fup NA 0.7729 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045658 Vd NA 2.679 L/kg 1compartment NA NA Rat Human +DTXSID2045656 TK.Half.Life NA 1.501 hours 1compartment NA NA Rat Human +DTXSID2045656 Css NA 0.01064 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045656 Css NA 0.06444 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045656 Css NA 0.008738 mg/L PBTK NA 50% Rat Human +DTXSID2045656 Css NA 0.04929 mg/L PBTK NA 95% Rat Human +DTXSID2045658 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045658 Fup 0.726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045658 Vd NA 2.687 L/kg 1compartment NA NA Human Human +DTXSID2045658 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2045658 TK.Half.Life NA 24.15 hours 1compartment NA NA Human Human +DTXSID2045658 Css NA 0.7542 mg/L 3compartmentss NA 50% Human Human +DTXSID2045658 Css NA 6.105 mg/L 3compartmentss NA 95% Human Human +DTXSID2045658 Css NA 0.838 mg/L PBTK NA 50% Human Human +DTXSID2045658 Css NA 4.272 mg/L PBTK NA 95% Human Human +DTXSID2045658 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045658 Fup 0.726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045658 Vd NA 2.728 L/kg 1compartment NA NA Rat Human DTXSID2045658 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045658 TK.Half.Life NA 3.2 hours 1compartment NA NA Rat Human -DTXSID2045658 Css NA 0.07755 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045658 Css NA 0.6652 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045658 Css NA 0.08599 mg/L PBTK NA 50% Rat Human -DTXSID2045658 Css NA 0.4415 mg/L PBTK NA 95% Rat Human -DTXSID2045735 Clint NA 0.3362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045735 Fup NA 0.1328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045735 Vd NA 0.3071 L/kg 1compartment NA NA Human Human -DTXSID2045735 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045735 TK.Half.Life NA 9.432 hours 1compartment NA NA Human Human -DTXSID2045735 Css NA 4.536 mg/L 3compartmentss NA 50% Human Human -DTXSID2045735 Css NA 21.9 mg/L 3compartmentss NA 95% Human Human -DTXSID2045735 Css NA 2.827 mg/L PBTK NA 50% Human Human -DTXSID2045735 Css NA 12.98 mg/L PBTK NA 95% Human Human -DTXSID2045735 Clint NA 0.3362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045735 Fup NA 0.1328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045735 Vd NA 0.312 L/kg 1compartment NA NA Rat Human -DTXSID2045735 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045735 TK.Half.Life NA 4.03 hours 1compartment NA NA Rat Human -DTXSID2045735 Css NA 1.603 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045735 Css NA 6.473 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045735 Css NA 0.9426 mg/L PBTK NA 50% Rat Human -DTXSID2045735 Css NA 3.581 mg/L PBTK NA 95% Rat Human -DTXSID2045781 Clint NA 39.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045781 Fup NA 0.9295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045781 Vd NA 3.457 L/kg 1compartment NA NA Human Human +DTXSID2045658 TK.Half.Life NA 8.301 hours 1compartment NA NA Rat Human +DTXSID2045658 Css NA 0.0444 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045658 Css NA 0.3448 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045658 Css NA 0.05072 mg/L PBTK NA 50% Rat Human +DTXSID2045658 Css NA 0.2355 mg/L PBTK NA 95% Rat Human +DTXSID2045781 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045781 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045781 Vd NA 0.8309 L/kg 1compartment NA NA Human Human DTXSID2045781 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045781 TK.Half.Life NA 7.446 hours 1compartment NA NA Human Human -DTXSID2045781 Css NA 0.1587 mg/L 3compartmentss NA 50% Human Human -DTXSID2045781 Css NA 1.035 mg/L 3compartmentss NA 95% Human Human -DTXSID2045781 Css NA 0.1203 mg/L PBTK NA 50% Human Human -DTXSID2045781 Css NA 0.7506 mg/L PBTK NA 95% Human Human -DTXSID2045781 Clint NA 39.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045781 Fup NA 0.9295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045781 Vd NA 2.708 L/kg 1compartment NA NA Rat Human +DTXSID2045781 TK.Half.Life NA 5.146 hours 1compartment NA NA Human Human +DTXSID2045781 Css NA 0.8405 mg/L 3compartmentss NA 50% Human Human +DTXSID2045781 Css NA 6.009 mg/L 3compartmentss NA 95% Human Human +DTXSID2045781 Css NA 0.5559 mg/L PBTK NA 50% Human Human +DTXSID2045781 Css NA 3.74 mg/L PBTK NA 95% Human Human +DTXSID2045781 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045781 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045781 Vd NA 0.821 L/kg 1compartment NA NA Rat Human DTXSID2045781 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045781 TK.Half.Life NA 1.532 hours 1compartment NA NA Rat Human -DTXSID2045781 Css NA 0.09005 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045781 Css NA 0.5014 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045781 Css NA 0.06539 mg/L PBTK NA 50% Rat Human -DTXSID2045781 Css NA 0.3473 mg/L PBTK NA 95% Rat Human -DTXSID2045783 Clint NA 105.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045783 Fup NA 0.5123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045783 Vd NA 3.95 L/kg 1compartment NA NA Human Human -DTXSID2045783 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045783 TK.Half.Life NA 1.771 hours 1compartment NA NA Human Human -DTXSID2045783 Css NA 0.004837 mg/L 3compartmentss NA 50% Human Human -DTXSID2045783 Css NA 0.05451 mg/L 3compartmentss NA 95% Human Human -DTXSID2045783 Css NA 0.006372 mg/L PBTK NA 50% Human Human -DTXSID2045783 Css NA 0.05177 mg/L PBTK NA 95% Human Human -DTXSID2045783 Clint NA 105.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045783 Fup NA 0.5123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045783 Vd NA 4.024 L/kg 1compartment NA NA Rat Human +DTXSID2045781 TK.Half.Life NA 3.111 hours 1compartment NA NA Rat Human +DTXSID2045781 Css NA 0.1026 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045781 Css NA 0.553 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045781 Css NA 0.06644 mg/L PBTK NA 50% Rat Human +DTXSID2045781 Css NA 0.3288 mg/L PBTK NA 95% Rat Human +DTXSID2045783 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045783 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045783 Vd NA 1.87 L/kg 1compartment NA NA Human Human +DTXSID2045783 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2045783 TK.Half.Life NA 24.75 hours 1compartment NA NA Human Human +DTXSID2045783 Css NA 1.122 mg/L 3compartmentss NA 50% Human Human +DTXSID2045783 Css NA 6.758 mg/L 3compartmentss NA 95% Human Human +DTXSID2045783 Css NA 1.082 mg/L PBTK NA 50% Human Human +DTXSID2045783 Css NA 4.681 mg/L PBTK NA 95% Human Human +DTXSID2045783 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045783 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045783 Vd NA 1.885 L/kg 1compartment NA NA Rat Human DTXSID2045783 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045783 TK.Half.Life NA 0.8462 hours 1compartment NA NA Rat Human -DTXSID2045783 Css NA 0.002466 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045783 Css NA 0.02544 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045783 Css NA 0.003308 mg/L PBTK NA 50% Rat Human -DTXSID2045783 Css NA 0.0232 mg/L PBTK NA 95% Rat Human -DTXSID2045785 Clint NA 5.828 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045785 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045785 Vd NA 1.227 L/kg 1compartment NA NA Human Human +DTXSID2045783 TK.Half.Life NA 8.501 hours 1compartment NA NA Rat Human +DTXSID2045783 Css NA 0.06962 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045783 Css NA 0.3571 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045783 Css NA 0.06786 mg/L PBTK NA 50% Rat Human +DTXSID2045783 Css NA 0.2415 mg/L PBTK NA 95% Rat Human +DTXSID2045785 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045785 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045785 Vd NA 1.57 L/kg 1compartment NA NA Human Human DTXSID2045785 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045785 TK.Half.Life NA 7.035 hours 1compartment NA NA Human Human -DTXSID2045785 Css NA 0.7343 mg/L 3compartmentss NA 50% Human Human -DTXSID2045785 Css NA 5.764 mg/L 3compartmentss NA 95% Human Human -DTXSID2045785 Css NA 0.5426 mg/L PBTK NA 50% Human Human -DTXSID2045785 Css NA 3.765 mg/L PBTK NA 95% Human Human -DTXSID2045785 Clint NA 5.828 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045785 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045785 Vd NA 1.191 L/kg 1compartment NA NA Rat Human +DTXSID2045785 TK.Half.Life NA 2.14 hours 1compartment NA NA Human Human +DTXSID2045785 Css NA 0.07472 mg/L 3compartmentss NA 50% Human Human +DTXSID2045785 Css NA 0.5882 mg/L 3compartmentss NA 95% Human Human +DTXSID2045785 Css NA 0.06166 mg/L PBTK NA 50% Human Human +DTXSID2045785 Css NA 0.4254 mg/L PBTK NA 95% Human Human +DTXSID2045785 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045785 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045785 Vd NA 1.564 L/kg 1compartment NA NA Rat Human DTXSID2045785 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045785 TK.Half.Life NA 4.287 hours 1compartment NA NA Rat Human -DTXSID2045785 Css NA 0.3946 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045785 Css NA 2.328 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045785 Css NA 0.2796 mg/L PBTK NA 50% Rat Human -DTXSID2045785 Css NA 1.428 mg/L PBTK NA 95% Rat Human -DTXSID2045787 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045787 Fup NA 0.9085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045787 Vd NA 0.6686 L/kg 1compartment NA NA Human Human +DTXSID2045785 TK.Half.Life NA 1.193 hours 1compartment NA NA Rat Human +DTXSID2045785 Css NA 0.009265 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045785 Css NA 0.05419 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045785 Css NA 0.007775 mg/L PBTK NA 50% Rat Human +DTXSID2045785 Css NA 0.03918 mg/L PBTK NA 95% Rat Human +DTXSID2045787 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045787 Fup 0.654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045787 Vd NA 0.3888 L/kg 1compartment NA NA Human Human DTXSID2045787 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045787 TK.Half.Life NA 4.761 hours 1compartment NA NA Human Human -DTXSID2045787 Css NA 0.9492 mg/L 3compartmentss NA 50% Human Human -DTXSID2045787 Css NA 5.223 mg/L 3compartmentss NA 95% Human Human -DTXSID2045787 Css NA 0.7636 mg/L PBTK NA 50% Human Human -DTXSID2045787 Css NA 3.393 mg/L PBTK NA 95% Human Human -DTXSID2045787 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045787 Fup NA 0.9085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045787 Vd NA 0.709 L/kg 1compartment NA NA Rat Human +DTXSID2045787 TK.Half.Life NA 3.847 hours 1compartment NA NA Human Human +DTXSID2045787 Css NA 0.7024 mg/L 3compartmentss NA 50% Human Human +DTXSID2045787 Css NA 4.278 mg/L 3compartmentss NA 95% Human Human +DTXSID2045787 Css NA 0.5024 mg/L PBTK NA 50% Human Human +DTXSID2045787 Css NA 2.648 mg/L PBTK NA 95% Human Human +DTXSID2045787 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045787 Fup 0.654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045787 Vd NA 0.4114 L/kg 1compartment NA NA Rat Human DTXSID2045787 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045787 TK.Half.Life NA 1.721 hours 1compartment NA NA Rat Human -DTXSID2045787 Css NA 0.2426 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045787 Css NA 1.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045787 Css NA 0.1893 mg/L PBTK NA 50% Rat Human -DTXSID2045787 Css NA 0.8111 mg/L PBTK NA 95% Rat Human -DTXSID2045789 Clint NA 0.09083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045789 Fup NA 0.8875 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045789 Vd NA 1.284 L/kg 1compartment NA NA Human Human +DTXSID2045787 TK.Half.Life NA 1.387 hours 1compartment NA NA Rat Human +DTXSID2045787 Css NA 0.003698 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045787 Css NA 0.02421 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045787 Css NA 0.002548 mg/L PBTK NA 50% Rat Human +DTXSID2045787 Css NA 0.01424 mg/L PBTK NA 95% Rat Human +DTXSID2045789 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045789 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045789 Vd NA 0.5163 L/kg 1compartment NA NA Human Human DTXSID2045789 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045789 TK.Half.Life NA 8.397 hours 1compartment NA NA Human Human -DTXSID2045789 Css NA 0.7328 mg/L 3compartmentss NA 50% Human Human -DTXSID2045789 Css NA 4.355 mg/L 3compartmentss NA 95% Human Human -DTXSID2045789 Css NA 0.6693 mg/L PBTK NA 50% Human Human -DTXSID2045789 Css NA 2.928 mg/L PBTK NA 95% Human Human -DTXSID2045789 Clint NA 0.09083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045789 Fup NA 0.8875 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045789 Vd NA 1.25 L/kg 1compartment NA NA Rat Human +DTXSID2045789 TK.Half.Life NA 6.945 hours 1compartment NA NA Human Human +DTXSID2045789 Css NA 1.297 mg/L 3compartmentss NA 50% Human Human +DTXSID2045789 Css NA 6.576 mg/L 3compartmentss NA 95% Human Human +DTXSID2045789 Css NA 0.9596 mg/L PBTK NA 50% Human Human +DTXSID2045789 Css NA 4.145 mg/L PBTK NA 95% Human Human +DTXSID2045789 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045789 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045789 Vd NA 0.544 L/kg 1compartment NA NA Rat Human DTXSID2045789 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045789 TK.Half.Life NA 2.915 hours 1compartment NA NA Rat Human -DTXSID2045789 Css NA 0.2002 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045789 Css NA 1.222 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045789 Css NA 0.1793 mg/L PBTK NA 50% Rat Human -DTXSID2045789 Css NA 0.7629 mg/L PBTK NA 95% Rat Human -DTXSID2045810 Clint NA 17.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045810 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045810 Vd NA 2.523 L/kg 1compartment NA NA Human Human -DTXSID2045810 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045810 TK.Half.Life NA 12.87 hours 1compartment NA NA Human Human -DTXSID2045810 Css NA 0.65 mg/L 3compartmentss NA 50% Human Human -DTXSID2045810 Css NA 5.327 mg/L 3compartmentss NA 95% Human Human -DTXSID2045810 Css NA 0.4586 mg/L PBTK NA 50% Human Human -DTXSID2045810 Css NA 3.478 mg/L PBTK NA 95% Human Human -DTXSID2045810 Clint NA 17.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045810 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045810 Vd NA 2.054 L/kg 1compartment NA NA Rat Human -DTXSID2045810 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045810 TK.Half.Life NA 4.507 hours 1compartment NA NA Rat Human -DTXSID2045810 Css NA 0.3609 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045810 Css NA 2.305 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045810 Css NA 0.2449 mg/L PBTK NA 50% Rat Human -DTXSID2045810 Css NA 1.435 mg/L PBTK NA 95% Rat Human -DTXSID2045812 Clint NA 22.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045812 Fup NA 0.3177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045812 Vd NA 1.965 L/kg 1compartment NA NA Human Human +DTXSID2045789 TK.Half.Life NA 2.494 hours 1compartment NA NA Rat Human +DTXSID2045789 Css NA 0.02434 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045789 Css NA 0.1636 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045789 Css NA 0.01725 mg/L PBTK NA 50% Rat Human +DTXSID2045789 Css NA 0.1043 mg/L PBTK NA 95% Rat Human +DTXSID2045810 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045810 Fup 0.0619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045810 Vd NA 2.247 L/kg 1compartment NA NA Human Human +DTXSID2045810 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2045810 TK.Half.Life NA 34.73 hours 1compartment NA NA Human Human +DTXSID2045810 Css NA 2.164 mg/L 3compartmentss NA 50% Human Human +DTXSID2045810 Css NA 13.15 mg/L 3compartmentss NA 95% Human Human +DTXSID2045810 Css NA 1.442 mg/L PBTK NA 50% Human Human +DTXSID2045810 Css NA 8.341 mg/L PBTK NA 95% Human Human +DTXSID2045810 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045810 Fup 0.0619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045810 Vd NA 1.688 L/kg 1compartment NA NA Rat Human +DTXSID2045810 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2045810 TK.Half.Life NA 9.678 hours 1compartment NA NA Rat Human +DTXSID2045810 Css NA 0.2676 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045810 Css NA 1.207 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045810 Css NA 0.1756 mg/L PBTK NA 50% Rat Human +DTXSID2045810 Css NA 0.7511 mg/L PBTK NA 95% Rat Human +DTXSID2045812 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045812 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045812 Vd NA 2.75 L/kg 1compartment NA NA Human Human DTXSID2045812 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045812 TK.Half.Life NA 2.157 hours 1compartment NA NA Human Human -DTXSID2045812 Css NA 0.05254 mg/L 3compartmentss NA 50% Human Human -DTXSID2045812 Css NA 0.4147 mg/L 3compartmentss NA 95% Human Human -DTXSID2045812 Css NA 0.0471 mg/L PBTK NA 50% Human Human -DTXSID2045812 Css NA 0.3209 mg/L PBTK NA 95% Human Human -DTXSID2045812 Clint NA 22.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045812 Fup NA 0.3177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045812 Vd NA 1.953 L/kg 1compartment NA NA Rat Human +DTXSID2045812 TK.Half.Life NA 6.836 hours 1compartment NA NA Human Human +DTXSID2045812 Css NA 0.177 mg/L 3compartmentss NA 50% Human Human +DTXSID2045812 Css NA 1.239 mg/L 3compartmentss NA 95% Human Human +DTXSID2045812 Css NA 0.1704 mg/L PBTK NA 50% Human Human +DTXSID2045812 Css NA 0.989 mg/L PBTK NA 95% Human Human +DTXSID2045812 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045812 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045812 Vd NA 2.642 L/kg 1compartment NA NA Rat Human DTXSID2045812 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045812 TK.Half.Life NA 1.149 hours 1compartment NA NA Rat Human -DTXSID2045812 Css NA 0.02747 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045812 Css NA 0.17 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045812 Css NA 0.02398 mg/L PBTK NA 50% Rat Human -DTXSID2045812 Css NA 0.1255 mg/L PBTK NA 95% Rat Human -DTXSID2045814 Clint NA 24.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045814 Fup NA 0.2401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045814 Vd NA 3.424 L/kg 1compartment NA NA Human Human +DTXSID2045812 TK.Half.Life NA 3.524 hours 1compartment NA NA Rat Human +DTXSID2045812 Css NA 0.0203 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045812 Css NA 0.1028 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045812 Css NA 0.02018 mg/L PBTK NA 50% Rat Human +DTXSID2045812 Css NA 0.08127 mg/L PBTK NA 95% Rat Human +DTXSID2045814 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045814 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045814 Vd NA 0.9459 L/kg 1compartment NA NA Human Human DTXSID2045814 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045814 TK.Half.Life NA 3.373 hours 1compartment NA NA Human Human -DTXSID2045814 Css NA 0.04199 mg/L 3compartmentss NA 50% Human Human -DTXSID2045814 Css NA 0.3359 mg/L 3compartmentss NA 95% Human Human -DTXSID2045814 Css NA 0.04756 mg/L PBTK NA 50% Human Human -DTXSID2045814 Css NA 0.3113 mg/L PBTK NA 95% Human Human -DTXSID2045814 Clint NA 24.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045814 Fup NA 0.2401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045814 Vd NA 3.46 L/kg 1compartment NA NA Rat Human +DTXSID2045814 TK.Half.Life NA 1.929 hours 1compartment NA NA Human Human +DTXSID2045814 Css NA 0.1562 mg/L 3compartmentss NA 50% Human Human +DTXSID2045814 Css NA 1.095 mg/L 3compartmentss NA 95% Human Human +DTXSID2045814 Css NA 0.1233 mg/L PBTK NA 50% Human Human +DTXSID2045814 Css NA 0.743 mg/L PBTK NA 95% Human Human +DTXSID2045814 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045814 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045814 Vd NA 0.9624 L/kg 1compartment NA NA Rat Human DTXSID2045814 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045814 TK.Half.Life NA 1.896 hours 1compartment NA NA Rat Human -DTXSID2045814 Css NA 0.02178 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045814 Css NA 0.1438 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045814 Css NA 0.02519 mg/L PBTK NA 50% Rat Human -DTXSID2045814 Css NA 0.1289 mg/L PBTK NA 95% Rat Human -DTXSID2045860 Clint NA 81.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045860 Fup NA 0.0357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045860 Vd NA 2.948 L/kg 1compartment NA NA Human Human +DTXSID2045814 TK.Half.Life NA 1.108 hours 1compartment NA NA Rat Human +DTXSID2045814 Css NA 0.01818 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045814 Css NA 0.09252 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045814 Css NA 0.01443 mg/L PBTK NA 50% Rat Human +DTXSID2045814 Css NA 0.06112 mg/L PBTK NA 95% Rat Human +DTXSID2045860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045860 Fup 0.0192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045860 Vd NA 1.751 L/kg 1compartment NA NA Human Human DTXSID2045860 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045860 TK.Half.Life NA 2.475 hours 1compartment NA NA Human Human -DTXSID2045860 Css NA 0.02518 mg/L 3compartmentss NA 50% Human Human -DTXSID2045860 Css NA 0.2082 mg/L 3compartmentss NA 95% Human Human -DTXSID2045860 Css NA 0.02035 mg/L PBTK NA 50% Human Human -DTXSID2045860 Css NA 0.1497 mg/L PBTK NA 95% Human Human -DTXSID2045860 Clint NA 81.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045860 Fup NA 0.0357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045860 Vd NA 2.616 L/kg 1compartment NA NA Rat Human +DTXSID2045860 TK.Half.Life NA 4.324 hours 1compartment NA NA Human Human +DTXSID2045860 Css NA 0.2648 mg/L 3compartmentss NA 50% Human Human +DTXSID2045860 Css NA 2.83 mg/L 3compartmentss NA 95% Human Human +DTXSID2045860 Css NA 0.186 mg/L PBTK NA 50% Human Human +DTXSID2045860 Css NA 1.792 mg/L PBTK NA 95% Human Human +DTXSID2045860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045860 Fup 0.0192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045860 Vd NA 1.592 L/kg 1compartment NA NA Rat Human DTXSID2045860 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045860 TK.Half.Life NA 0.9898 hours 1compartment NA NA Rat Human -DTXSID2045860 Css NA 0.01398 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045860 Css NA 0.09737 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045860 Css NA 0.0109 mg/L PBTK NA 50% Rat Human -DTXSID2045860 Css NA 0.06936 mg/L PBTK NA 95% Rat Human -DTXSID2045862 Clint NA 24.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045862 Fup NA 0.5022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045862 Vd NA 1.8 L/kg 1compartment NA NA Human Human +DTXSID2045860 TK.Half.Life NA 2.25 hours 1compartment NA NA Rat Human +DTXSID2045860 Css NA 0.0343 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045860 Css NA 0.3313 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045860 Css NA 0.02374 mg/L PBTK NA 50% Rat Human +DTXSID2045860 Css NA 0.2039 mg/L PBTK NA 95% Rat Human +DTXSID2045862 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045862 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045862 Vd NA 2.412 L/kg 1compartment NA NA Human Human DTXSID2045862 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045862 TK.Half.Life NA 1.612 hours 1compartment NA NA Human Human -DTXSID2045862 Css NA 0.03402 mg/L 3compartmentss NA 50% Human Human -DTXSID2045862 Css NA 0.3035 mg/L 3compartmentss NA 95% Human Human -DTXSID2045862 Css NA 0.03048 mg/L PBTK NA 50% Human Human -DTXSID2045862 Css NA 0.2265 mg/L PBTK NA 95% Human Human -DTXSID2045862 Clint NA 24.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045862 Fup NA 0.5022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045862 Vd NA 1.676 L/kg 1compartment NA NA Rat Human +DTXSID2045862 TK.Half.Life NA 5.436 hours 1compartment NA NA Human Human +DTXSID2045862 Css NA 0.1706 mg/L 3compartmentss NA 50% Human Human +DTXSID2045862 Css NA 1.093 mg/L 3compartmentss NA 95% Human Human +DTXSID2045862 Css NA 0.1514 mg/L PBTK NA 50% Human Human +DTXSID2045862 Css NA 0.8251 mg/L PBTK NA 95% Human Human +DTXSID2045862 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045862 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045862 Vd NA 2.093 L/kg 1compartment NA NA Rat Human DTXSID2045862 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045862 TK.Half.Life NA 0.7404 hours 1compartment NA NA Rat Human -DTXSID2045862 Css NA 0.01791 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045862 Css NA 0.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045862 Css NA 0.01575 mg/L PBTK NA 50% Rat Human -DTXSID2045862 Css NA 0.09395 mg/L PBTK NA 95% Rat Human -DTXSID2045864 Clint NA 55.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045864 Fup NA 0.1126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045864 Vd NA 1.01 L/kg 1compartment NA NA Human Human +DTXSID2045862 TK.Half.Life NA 2.16 hours 1compartment NA NA Rat Human +DTXSID2045862 Css NA 0.01947 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045862 Css NA 0.1013 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045862 Css NA 0.01759 mg/L PBTK NA 50% Rat Human +DTXSID2045862 Css NA 0.07295 mg/L PBTK NA 95% Rat Human +DTXSID2045864 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045864 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045864 Vd NA 2.292 L/kg 1compartment NA NA Human Human DTXSID2045864 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045864 TK.Half.Life NA 1.439 hours 1compartment NA NA Human Human -DTXSID2045864 Css NA 0.09572 mg/L 3compartmentss NA 50% Human Human -DTXSID2045864 Css NA 0.8173 mg/L 3compartmentss NA 95% Human Human -DTXSID2045864 Css NA 0.06439 mg/L PBTK NA 50% Human Human -DTXSID2045864 Css NA 0.5149 mg/L PBTK NA 95% Human Human -DTXSID2045864 Clint NA 55.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045864 Fup NA 0.1126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045864 Vd NA 0.8924 L/kg 1compartment NA NA Rat Human +DTXSID2045864 TK.Half.Life NA 5.991 hours 1compartment NA NA Human Human +DTXSID2045864 Css NA 0.2056 mg/L 3compartmentss NA 50% Human Human +DTXSID2045864 Css NA 1.25 mg/L 3compartmentss NA 95% Human Human +DTXSID2045864 Css NA 0.1776 mg/L PBTK NA 50% Human Human +DTXSID2045864 Css NA 0.9541 mg/L PBTK NA 95% Human Human +DTXSID2045864 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045864 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045864 Vd NA 1.998 L/kg 1compartment NA NA Rat Human DTXSID2045864 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045864 TK.Half.Life NA 0.6723 hours 1compartment NA NA Rat Human -DTXSID2045864 Css NA 0.0546 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045864 Css NA 0.3658 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045864 Css NA 0.03441 mg/L PBTK NA 50% Rat Human -DTXSID2045864 Css NA 0.2145 mg/L PBTK NA 95% Rat Human -DTXSID2045868 Clint NA 10.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045868 Fup NA 0.2602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045868 Vd NA 3.047 L/kg 1compartment NA NA Human Human -DTXSID2045868 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2045868 TK.Half.Life NA 24.07 hours 1compartment NA NA Human Human -DTXSID2045868 Css NA 0.852 mg/L 3compartmentss NA 50% Human Human -DTXSID2045868 Css NA 4.813 mg/L 3compartmentss NA 95% Human Human -DTXSID2045868 Css NA 0.6237 mg/L PBTK NA 50% Human Human -DTXSID2045868 Css NA 3.421 mg/L PBTK NA 95% Human Human -DTXSID2045868 Clint NA 10.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045868 Fup NA 0.2602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045868 Vd NA 2.34 L/kg 1compartment NA NA Rat Human -DTXSID2045868 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2045868 TK.Half.Life NA 4.455 hours 1compartment NA NA Rat Human -DTXSID2045868 Css NA 0.4524 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045868 Css NA 1.956 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045868 Css NA 0.321 mg/L PBTK NA 50% Rat Human -DTXSID2045868 Css NA 1.344 mg/L PBTK NA 95% Rat Human -DTXSID2045941 Clint NA 2.098 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045941 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045941 Vd NA 0.4318 L/kg 1compartment NA NA Human Human -DTXSID2045941 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045941 TK.Half.Life NA 5.373 hours 1compartment NA NA Human Human -DTXSID2045941 Css NA 1.852 mg/L 3compartmentss NA 50% Human Human -DTXSID2045941 Css NA 10.82 mg/L 3compartmentss NA 95% Human Human -DTXSID2045941 Css NA 1.181 mg/L PBTK NA 50% Human Human -DTXSID2045941 Css NA 6.476 mg/L PBTK NA 95% Human Human -DTXSID2045941 Clint NA 2.098 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045941 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045941 Vd NA 0.388 L/kg 1compartment NA NA Rat Human +DTXSID2045864 TK.Half.Life NA 2.486 hours 1compartment NA NA Rat Human +DTXSID2045864 Css NA 0.02398 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045864 Css NA 0.1105 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045864 Css NA 0.02086 mg/L PBTK NA 50% Rat Human +DTXSID2045864 Css NA 0.08181 mg/L PBTK NA 95% Rat Human +DTXSID2045868 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045868 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045868 Vd NA 2.679 L/kg 1compartment NA NA Human Human +DTXSID2045868 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045868 TK.Half.Life NA 5.55 hours 1compartment NA NA Human Human +DTXSID2045868 Css NA 0.1514 mg/L 3compartmentss NA 50% Human Human +DTXSID2045868 Css NA 0.9877 mg/L 3compartmentss NA 95% Human Human +DTXSID2045868 Css NA 0.1174 mg/L PBTK NA 50% Human Human +DTXSID2045868 Css NA 0.7242 mg/L PBTK NA 95% Human Human +DTXSID2045868 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045868 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045868 Vd NA 2.126 L/kg 1compartment NA NA Rat Human +DTXSID2045868 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045868 TK.Half.Life NA 1.663 hours 1compartment NA NA Rat Human +DTXSID2045868 Css NA 0.01926 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045868 Css NA 0.09498 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045868 Css NA 0.01494 mg/L PBTK NA 50% Rat Human +DTXSID2045868 Css NA 0.07038 mg/L PBTK NA 95% Rat Human +DTXSID2045941 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045941 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045941 Vd NA 0.6498 L/kg 1compartment NA NA Human Human +DTXSID2045941 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2045941 TK.Half.Life NA 16.09 hours 1compartment NA NA Human Human +DTXSID2045941 Css NA 2.709 mg/L 3compartmentss NA 50% Human Human +DTXSID2045941 Css NA 10.81 mg/L 3compartmentss NA 95% Human Human +DTXSID2045941 Css NA 1.955 mg/L PBTK NA 50% Human Human +DTXSID2045941 Css NA 6.908 mg/L PBTK NA 95% Human Human +DTXSID2045941 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045941 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045941 Vd NA 0.5845 L/kg 1compartment NA NA Rat Human DTXSID2045941 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045941 TK.Half.Life NA 2.665 hours 1compartment NA NA Rat Human -DTXSID2045941 Css NA 0.8698 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045941 Css NA 3.866 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045941 Css NA 0.5196 mg/L PBTK NA 50% Rat Human -DTXSID2045941 Css NA 2.166 mg/L PBTK NA 95% Rat Human -DTXSID2045943 Clint NA 26.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045943 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045943 Vd NA 2.297 L/kg 1compartment NA NA Human Human -DTXSID2045943 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2045943 TK.Half.Life NA 23.5 hours 1compartment NA NA Human Human -DTXSID2045943 Css NA 1.488 mg/L 3compartmentss NA 50% Human Human -DTXSID2045943 Css NA 12.02 mg/L 3compartmentss NA 95% Human Human -DTXSID2045943 Css NA 0.9761 mg/L PBTK NA 50% Human Human -DTXSID2045943 Css NA 7.359 mg/L PBTK NA 95% Human Human -DTXSID2045943 Clint NA 26.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045943 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045943 Vd NA 1.71 L/kg 1compartment NA NA Rat Human -DTXSID2045943 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2045943 TK.Half.Life NA 6.576 hours 1compartment NA NA Rat Human -DTXSID2045943 Css NA 0.83 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045943 Css NA 5.152 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045943 Css NA 0.512 mg/L PBTK NA 50% Rat Human -DTXSID2045943 Css NA 3.091 mg/L PBTK NA 95% Rat Human -DTXSID2045945 Clint NA 9.688 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045945 Fup NA 0.0734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045945 Vd NA 2.055 L/kg 1compartment NA NA Human Human +DTXSID2045941 TK.Half.Life NA 4.824 hours 1compartment NA NA Rat Human +DTXSID2045941 Css NA 0.1745 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045941 Css NA 0.5703 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045941 Css NA 0.1243 mg/L PBTK NA 50% Rat Human +DTXSID2045941 Css NA 0.3502 mg/L PBTK NA 95% Rat Human +DTXSID2045943 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045943 Fup 0.0854 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045943 Vd NA 0.2899 L/kg 1compartment NA NA Human Human +DTXSID2045943 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2045943 TK.Half.Life NA 0.8464 hours 1compartment NA NA Human Human +DTXSID2045943 Css NA 0.3454 mg/L 3compartmentss NA 50% Human Human +DTXSID2045943 Css NA 2.801 mg/L 3compartmentss NA 95% Human Human +DTXSID2045943 Css NA 0.211 mg/L PBTK NA 50% Human Human +DTXSID2045943 Css NA 1.671 mg/L PBTK NA 95% Human Human +DTXSID2045943 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045943 Fup 0.0854 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045943 Vd NA 0.2836 L/kg 1compartment NA NA Rat Human +DTXSID2045943 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2045943 TK.Half.Life NA 0.4983 hours 1compartment NA NA Rat Human +DTXSID2045943 Css NA 0.04561 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045943 Css NA 0.2826 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045943 Css NA 0.02696 mg/L PBTK NA 50% Rat Human +DTXSID2045943 Css NA 0.1625 mg/L PBTK NA 95% Rat Human +DTXSID2045945 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045945 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045945 Vd NA 1.987 L/kg 1compartment NA NA Human Human DTXSID2045945 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2045945 TK.Half.Life NA 5.97 hours 1compartment NA NA Human Human -DTXSID2045945 Css NA 0.3006 mg/L 3compartmentss NA 50% Human Human -DTXSID2045945 Css NA 2.715 mg/L 3compartmentss NA 95% Human Human -DTXSID2045945 Css NA 0.2534 mg/L PBTK NA 50% Human Human -DTXSID2045945 Css NA 1.925 mg/L PBTK NA 95% Human Human -DTXSID2045945 Clint NA 9.688 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045945 Fup NA 0.0734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045945 Vd NA 2.02 L/kg 1compartment NA NA Rat Human +DTXSID2045945 TK.Half.Life NA 3.294 hours 1compartment NA NA Human Human +DTXSID2045945 Css NA 0.1358 mg/L 3compartmentss NA 50% Human Human +DTXSID2045945 Css NA 1.305 mg/L 3compartmentss NA 95% Human Human +DTXSID2045945 Css NA 0.1106 mg/L PBTK NA 50% Human Human +DTXSID2045945 Css NA 0.9053 mg/L PBTK NA 95% Human Human +DTXSID2045945 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045945 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045945 Vd NA 1.938 L/kg 1compartment NA NA Rat Human DTXSID2045945 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045945 TK.Half.Life NA 3.64 hours 1compartment NA NA Rat Human -DTXSID2045945 Css NA 0.1654 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045945 Css NA 1.142 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045945 Css NA 0.1336 mg/L PBTK NA 50% Rat Human -DTXSID2045945 Css NA 0.7758 mg/L PBTK NA 95% Rat Human -DTXSID2045993 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045993 Fup NA 0.9407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2045993 Vd NA 1.505 L/kg 1compartment NA NA Human Human +DTXSID2045945 TK.Half.Life NA 1.873 hours 1compartment NA NA Rat Human +DTXSID2045945 Css NA 0.01766 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045945 Css NA 0.1378 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045945 Css NA 0.01428 mg/L PBTK NA 50% Rat Human +DTXSID2045945 Css NA 0.09746 mg/L PBTK NA 95% Rat Human +DTXSID2045993 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045993 Fup 0.787 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2045993 Vd NA 1.339 L/kg 1compartment NA NA Human Human DTXSID2045993 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2045993 TK.Half.Life NA 10.35 hours 1compartment NA NA Human Human -DTXSID2045993 Css NA 0.7811 mg/L 3compartmentss NA 50% Human Human -DTXSID2045993 Css NA 4.607 mg/L 3compartmentss NA 95% Human Human -DTXSID2045993 Css NA 0.7502 mg/L PBTK NA 50% Human Human -DTXSID2045993 Css NA 3.21 mg/L PBTK NA 95% Human Human -DTXSID2045993 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045993 Fup NA 0.9407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2045993 Vd NA 1.556 L/kg 1compartment NA NA Rat Human +DTXSID2045993 TK.Half.Life NA 11.01 hours 1compartment NA NA Human Human +DTXSID2045993 Css NA 0.4834 mg/L 3compartmentss NA 50% Human Human +DTXSID2045993 Css NA 3.479 mg/L 3compartmentss NA 95% Human Human +DTXSID2045993 Css NA 0.449 mg/L PBTK NA 50% Human Human +DTXSID2045993 Css NA 2.343 mg/L PBTK NA 95% Human Human +DTXSID2045993 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045993 Fup 0.787 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2045993 Vd NA 1.383 L/kg 1compartment NA NA Rat Human DTXSID2045993 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2045993 TK.Half.Life NA 3.648 hours 1compartment NA NA Rat Human -DTXSID2045993 Css NA 0.1958 mg/L 3compartmentss NA 50% Rat Human -DTXSID2045993 Css NA 1.214 mg/L 3compartmentss NA 95% Rat Human -DTXSID2045993 Css NA 0.1854 mg/L PBTK NA 50% Rat Human -DTXSID2045993 Css NA 0.7737 mg/L PBTK NA 95% Rat Human -DTXSID2046042 Clint NA 64.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046042 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046042 Vd NA 3.097 L/kg 1compartment NA NA Human Human -DTXSID2046042 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2046042 TK.Half.Life NA 27.27 hours 1compartment NA NA Human Human -DTXSID2046042 Css NA 1.017 mg/L 3compartmentss NA 50% Human Human -DTXSID2046042 Css NA 6.488 mg/L 3compartmentss NA 95% Human Human -DTXSID2046042 Css NA 0.7046 mg/L PBTK NA 50% Human Human -DTXSID2046042 Css NA 4.327 mg/L PBTK NA 95% Human Human -DTXSID2046042 Clint NA 64.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046042 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046042 Vd NA 2.32 L/kg 1compartment NA NA Rat Human -DTXSID2046042 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2046042 TK.Half.Life NA 4.141 hours 1compartment NA NA Rat Human -DTXSID2046042 Css NA 0.5683 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046042 Css NA 2.928 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046042 Css NA 0.3765 mg/L PBTK NA 50% Rat Human -DTXSID2046042 Css NA 1.857 mg/L PBTK NA 95% Rat Human -DTXSID2046090 Clint NA 27.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046090 Fup NA 0.7266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046090 Vd NA 2.882 L/kg 1compartment NA NA Human Human +DTXSID2045993 TK.Half.Life NA 3.874 hours 1compartment NA NA Rat Human +DTXSID2045993 Css NA 0.002422 mg/L 3compartmentss NA 50% Rat Human +DTXSID2045993 Css NA 0.01754 mg/L 3compartmentss NA 95% Rat Human +DTXSID2045993 Css NA 0.00222 mg/L PBTK NA 50% Rat Human +DTXSID2045993 Css NA 0.01179 mg/L PBTK NA 95% Rat Human +DTXSID2046090 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046090 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046090 Vd NA 1.564 L/kg 1compartment NA NA Human Human DTXSID2046090 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046090 TK.Half.Life NA 1.742 hours 1compartment NA NA Human Human -DTXSID2046090 Css NA 0.0182 mg/L 3compartmentss NA 50% Human Human -DTXSID2046090 Css NA 0.2224 mg/L 3compartmentss NA 95% Human Human -DTXSID2046090 Css NA 0.02031 mg/L PBTK NA 50% Human Human -DTXSID2046090 Css NA 0.1823 mg/L PBTK NA 95% Human Human -DTXSID2046090 Clint NA 27.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046090 Fup NA 0.7266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046090 Vd NA 2.929 L/kg 1compartment NA NA Rat Human +DTXSID2046090 TK.Half.Life NA 2.172 hours 1compartment NA NA Human Human +DTXSID2046090 Css NA 0.09614 mg/L 3compartmentss NA 50% Human Human +DTXSID2046090 Css NA 0.9389 mg/L 3compartmentss NA 95% Human Human +DTXSID2046090 Css NA 0.0876 mg/L PBTK NA 50% Human Human +DTXSID2046090 Css NA 0.6561 mg/L PBTK NA 95% Human Human +DTXSID2046090 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046090 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046090 Vd NA 1.586 L/kg 1compartment NA NA Rat Human DTXSID2046090 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046090 TK.Half.Life NA 0.8831 hours 1compartment NA NA Rat Human -DTXSID2046090 Css NA 0.008976 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046090 Css NA 0.09639 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046090 Css NA 0.01019 mg/L PBTK NA 50% Rat Human -DTXSID2046090 Css NA 0.07485 mg/L PBTK NA 95% Rat Human -DTXSID2046092 Clint NA 9.096 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046092 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046092 Vd NA 0.8634 L/kg 1compartment NA NA Human Human +DTXSID2046090 TK.Half.Life NA 1.21 hours 1compartment NA NA Rat Human +DTXSID2046090 Css NA 0.01067 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046090 Css NA 0.08951 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046090 Css NA 0.009978 mg/L PBTK NA 50% Rat Human +DTXSID2046090 Css NA 0.05891 mg/L PBTK NA 95% Rat Human +DTXSID2046092 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046092 Fup 0.0468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046092 Vd NA 1.678 L/kg 1compartment NA NA Human Human DTXSID2046092 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046092 TK.Half.Life NA 9.864 hours 1compartment NA NA Human Human -DTXSID2046092 Css NA 1.974 mg/L 3compartmentss NA 50% Human Human -DTXSID2046092 Css NA 13.77 mg/L 3compartmentss NA 95% Human Human -DTXSID2046092 Css NA 1.212 mg/L PBTK NA 50% Human Human -DTXSID2046092 Css NA 8.204 mg/L PBTK NA 95% Human Human -DTXSID2046092 Clint NA 9.096 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046092 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046092 Vd NA 0.6549 L/kg 1compartment NA NA Rat Human +DTXSID2046092 TK.Half.Life NA 8.648 hours 1compartment NA NA Human Human +DTXSID2046092 Css NA 0.6933 mg/L 3compartmentss NA 50% Human Human +DTXSID2046092 Css NA 4.986 mg/L 3compartmentss NA 95% Human Human +DTXSID2046092 Css NA 0.443 mg/L PBTK NA 50% Human Human +DTXSID2046092 Css NA 3.14 mg/L PBTK NA 95% Human Human +DTXSID2046092 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046092 Fup 0.0468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046092 Vd NA 1.255 L/kg 1compartment NA NA Rat Human DTXSID2046092 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046092 TK.Half.Life NA 4.438 hours 1compartment NA NA Rat Human -DTXSID2046092 Css NA 1.094 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046092 Css NA 5.836 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046092 Css NA 0.6244 mg/L PBTK NA 50% Rat Human -DTXSID2046092 Css NA 3.243 mg/L PBTK NA 95% Rat Human -DTXSID2046094 Clint NA 11.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046094 Fup NA 0.233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046094 Vd NA 2.761 L/kg 1compartment NA NA Human Human -DTXSID2046094 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2046094 TK.Half.Life NA 14.15 hours 1compartment NA NA Human Human -DTXSID2046094 Css NA 0.529 mg/L 3compartmentss NA 50% Human Human -DTXSID2046094 Css NA 2.947 mg/L 3compartmentss NA 95% Human Human -DTXSID2046094 Css NA 0.3848 mg/L PBTK NA 50% Human Human -DTXSID2046094 Css NA 2.037 mg/L PBTK NA 95% Human Human -DTXSID2046094 Clint NA 11.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046094 Fup NA 0.233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046094 Vd NA 2.096 L/kg 1compartment NA NA Rat Human -DTXSID2046094 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046094 TK.Half.Life NA 3.148 hours 1compartment NA NA Rat Human -DTXSID2046094 Css NA 0.2845 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046094 Css NA 1.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046094 Css NA 0.1994 mg/L PBTK NA 50% Rat Human -DTXSID2046094 Css NA 0.8223 mg/L PBTK NA 95% Rat Human -DTXSID2046096 Clint NA 32.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046096 Fup NA 0.6761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046096 Vd NA 4.231 L/kg 1compartment NA NA Human Human +DTXSID2046092 TK.Half.Life NA 3.145 hours 1compartment NA NA Rat Human +DTXSID2046092 Css NA 0.08858 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046092 Css NA 0.5347 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046092 Css NA 0.05547 mg/L PBTK NA 50% Rat Human +DTXSID2046092 Css NA 0.3231 mg/L PBTK NA 95% Rat Human +DTXSID2046094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046094 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046094 Vd NA 18.61 L/kg 1compartment NA NA Human Human +DTXSID2046094 Days.Css NA 124 Days PBTK NA NA Human Human +DTXSID2046094 TK.Half.Life NA 548.4 hours 1compartment NA NA Human Human +DTXSID2046094 Css NA 1.166 mg/L 3compartmentss NA 50% Human Human +DTXSID2046094 Css NA 7.272 mg/L 3compartmentss NA 95% Human Human +DTXSID2046094 Css NA 2.321 mg/L PBTK NA 50% Human Human +DTXSID2046094 Css NA 13.51 mg/L PBTK NA 95% Human Human +DTXSID2046094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046094 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046094 Vd NA 15.06 L/kg 1compartment NA NA Rat Human +DTXSID2046094 Days.Css NA 76 Days PBTK NA NA Rat Human +DTXSID2046094 TK.Half.Life NA 75.59 hours 1compartment NA NA Rat Human +DTXSID2046094 Css NA 0.1429 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046094 Css NA 0.7191 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046094 Css NA 0.3024 mg/L PBTK NA 50% Rat Human +DTXSID2046094 Css NA 1.583 mg/L PBTK NA 95% Rat Human +DTXSID2046096 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046096 Fup 0.49 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046096 Vd NA 1.548 L/kg 1compartment NA NA Human Human DTXSID2046096 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046096 TK.Half.Life NA 2.152 hours 1compartment NA NA Human Human -DTXSID2046096 Css NA 0.01288 mg/L 3compartmentss NA 50% Human Human -DTXSID2046096 Css NA 0.1642 mg/L 3compartmentss NA 95% Human Human -DTXSID2046096 Css NA 0.01756 mg/L PBTK NA 50% Human Human -DTXSID2046096 Css NA 0.1491 mg/L PBTK NA 95% Human Human -DTXSID2046096 Clint NA 32.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046096 Fup NA 0.6761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046096 Vd NA 4.32 L/kg 1compartment NA NA Rat Human +DTXSID2046096 TK.Half.Life NA 2.965 hours 1compartment NA NA Human Human +DTXSID2046096 Css NA 0.1418 mg/L 3compartmentss NA 50% Human Human +DTXSID2046096 Css NA 1.014 mg/L 3compartmentss NA 95% Human Human +DTXSID2046096 Css NA 0.1173 mg/L PBTK NA 50% Human Human +DTXSID2046096 Css NA 0.7396 mg/L PBTK NA 95% Human Human +DTXSID2046096 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046096 Fup 0.49 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046096 Vd NA 1.298 L/kg 1compartment NA NA Rat Human DTXSID2046096 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046096 TK.Half.Life NA 1.114 hours 1compartment NA NA Rat Human -DTXSID2046096 Css NA 0.006282 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046096 Css NA 0.07847 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046096 Css NA 0.008915 mg/L PBTK NA 50% Rat Human -DTXSID2046096 Css NA 0.06627 mg/L PBTK NA 95% Rat Human -DTXSID2046121 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046121 Fup NA 0.0068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046121 Vd NA 0.1929 L/kg 1compartment NA NA Human Human -DTXSID2046121 Days.Css NA 43 Days PBTK NA NA Human Human -DTXSID2046121 TK.Half.Life NA 183.8 hours 1compartment NA NA Human Human -DTXSID2046121 Css NA 166.6 mg/L 3compartmentss NA 50% Human Human -DTXSID2046121 Css NA 1018 mg/L 3compartmentss NA 95% Human Human -DTXSID2046121 Css NA 96.81 mg/L PBTK NA 50% Human Human -DTXSID2046121 Css NA 588 mg/L PBTK NA 95% Human Human -DTXSID2046121 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046121 Fup NA 0.0068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046121 Vd NA 0.1803 L/kg 1compartment NA NA Rat Human -DTXSID2046121 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID2046121 TK.Half.Life NA 58.49 hours 1compartment NA NA Rat Human -DTXSID2046121 Css NA 47.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046121 Css NA 253.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046121 Css NA 25.72 mg/L PBTK NA 50% Rat Human -DTXSID2046121 Css NA 136.8 mg/L PBTK NA 95% Rat Human -DTXSID2046123 Clint NA 11.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046123 Fup NA 0.0979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046123 Vd NA 0.8874 L/kg 1compartment NA NA Human Human +DTXSID2046096 TK.Half.Life NA 1.234 hours 1compartment NA NA Rat Human +DTXSID2046096 Css NA 0.01663 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046096 Css NA 0.09074 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046096 Css NA 0.01393 mg/L PBTK NA 50% Rat Human +DTXSID2046096 Css NA 0.06323 mg/L PBTK NA 95% Rat Human +DTXSID2046121 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046121 Fup 0.0617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046121 Vd NA 0.3973 L/kg 1compartment NA NA Human Human +DTXSID2046121 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046121 TK.Half.Life NA 1.452 hours 1compartment NA NA Human Human +DTXSID2046121 Css NA 0.486 mg/L 3compartmentss NA 50% Human Human +DTXSID2046121 Css NA 3.482 mg/L 3compartmentss NA 95% Human Human +DTXSID2046121 Css NA 0.2944 mg/L PBTK NA 50% Human Human +DTXSID2046121 Css NA 2.061 mg/L PBTK NA 95% Human Human +DTXSID2046121 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046121 Fup 0.0617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046121 Vd NA 0.3391 L/kg 1compartment NA NA Rat Human +DTXSID2046121 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2046121 TK.Half.Life NA 0.7587 hours 1compartment NA NA Rat Human +DTXSID2046121 Css NA 0.06326 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046121 Css NA 0.3542 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046121 Css NA 0.03733 mg/L PBTK NA 50% Rat Human +DTXSID2046121 Css NA 0.2054 mg/L PBTK NA 95% Rat Human +DTXSID2046123 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046123 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046123 Vd NA 1.216 L/kg 1compartment NA NA Human Human DTXSID2046123 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046123 TK.Half.Life NA 3.236 hours 1compartment NA NA Human Human -DTXSID2046123 Css NA 0.4445 mg/L 3compartmentss NA 50% Human Human -DTXSID2046123 Css NA 3.519 mg/L 3compartmentss NA 95% Human Human -DTXSID2046123 Css NA 0.3094 mg/L PBTK NA 50% Human Human -DTXSID2046123 Css NA 2.241 mg/L PBTK NA 95% Human Human -DTXSID2046123 Clint NA 11.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046123 Fup NA 0.0979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046123 Vd NA 0.8575 L/kg 1compartment NA NA Rat Human +DTXSID2046123 TK.Half.Life NA 3.786 hours 1compartment NA NA Human Human +DTXSID2046123 Css NA 0.265 mg/L 3compartmentss NA 50% Human Human +DTXSID2046123 Css NA 1.654 mg/L 3compartmentss NA 95% Human Human +DTXSID2046123 Css NA 0.2116 mg/L PBTK NA 50% Human Human +DTXSID2046123 Css NA 1.182 mg/L PBTK NA 95% Human Human +DTXSID2046123 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046123 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046123 Vd NA 1.184 L/kg 1compartment NA NA Rat Human DTXSID2046123 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046123 TK.Half.Life NA 1.929 hours 1compartment NA NA Rat Human -DTXSID2046123 Css NA 0.2416 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046123 Css NA 1.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046123 Css NA 0.1586 mg/L PBTK NA 50% Rat Human -DTXSID2046123 Css NA 0.8887 mg/L PBTK NA 95% Rat Human -DTXSID2046127 Clint NA 42.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046127 Fup NA 0.0284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046127 Vd NA 0.7887 L/kg 1compartment NA NA Human Human +DTXSID2046123 TK.Half.Life NA 2.195 hours 1compartment NA NA Rat Human +DTXSID2046123 Css NA 0.03091 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046123 Css NA 0.1491 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046123 Css NA 0.0249 mg/L PBTK NA 50% Rat Human +DTXSID2046123 Css NA 0.1022 mg/L PBTK NA 95% Rat Human +DTXSID2046127 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046127 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046127 Vd NA 1.867 L/kg 1compartment NA NA Human Human DTXSID2046127 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046127 TK.Half.Life NA 3.056 hours 1compartment NA NA Human Human -DTXSID2046127 Css NA 0.5581 mg/L 3compartmentss NA 50% Human Human -DTXSID2046127 Css NA 5.344 mg/L 3compartmentss NA 95% Human Human -DTXSID2046127 Css NA 0.3398 mg/L PBTK NA 50% Human Human -DTXSID2046127 Css NA 3.125 mg/L PBTK NA 95% Human Human -DTXSID2046127 Clint NA 42.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046127 Fup NA 0.0284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046127 Vd NA 0.6058 L/kg 1compartment NA NA Rat Human +DTXSID2046127 TK.Half.Life NA 11.49 hours 1compartment NA NA Human Human +DTXSID2046127 Css NA 0.7448 mg/L 3compartmentss NA 50% Human Human +DTXSID2046127 Css NA 4.627 mg/L 3compartmentss NA 95% Human Human +DTXSID2046127 Css NA 0.52 mg/L PBTK NA 50% Human Human +DTXSID2046127 Css NA 3.003 mg/L PBTK NA 95% Human Human +DTXSID2046127 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046127 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046127 Vd NA 1.446 L/kg 1compartment NA NA Rat Human DTXSID2046127 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046127 TK.Half.Life NA 1.397 hours 1compartment NA NA Rat Human -DTXSID2046127 Css NA 0.313 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046127 Css NA 2.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046127 Css NA 0.1782 mg/L PBTK NA 50% Rat Human -DTXSID2046127 Css NA 1.392 mg/L PBTK NA 95% Rat Human -DTXSID2046171 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046171 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046171 Vd NA 0.7239 L/kg 1compartment NA NA Human Human +DTXSID2046127 TK.Half.Life NA 4.025 hours 1compartment NA NA Rat Human +DTXSID2046127 Css NA 0.09001 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046127 Css NA 0.4126 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046127 Css NA 0.06175 mg/L PBTK NA 50% Rat Human +DTXSID2046127 Css NA 0.2619 mg/L PBTK NA 95% Rat Human +DTXSID2046171 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046171 Fup 0.924 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046171 Vd NA 0.6796 L/kg 1compartment NA NA Human Human DTXSID2046171 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046171 TK.Half.Life NA 4.687 hours 1compartment NA NA Human Human -DTXSID2046171 Css NA 0.8412 mg/L 3compartmentss NA 50% Human Human -DTXSID2046171 Css NA 5.534 mg/L 3compartmentss NA 95% Human Human -DTXSID2046171 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID2046171 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID2046171 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046171 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046171 Vd NA 0.7697 L/kg 1compartment NA NA Rat Human +DTXSID2046171 TK.Half.Life NA 4.757 hours 1compartment NA NA Human Human +DTXSID2046171 Css NA 0.8682 mg/L 3compartmentss NA 50% Human Human +DTXSID2046171 Css NA 3.175 mg/L 3compartmentss NA 95% Human Human +DTXSID2046171 Css NA 0.7094 mg/L PBTK NA 50% Human Human +DTXSID2046171 Css NA 2.187 mg/L PBTK NA 95% Human Human +DTXSID2046171 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046171 Fup 0.924 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046171 Vd NA 0.7249 L/kg 1compartment NA NA Rat Human DTXSID2046171 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046171 TK.Half.Life NA 1.697 hours 1compartment NA NA Rat Human -DTXSID2046171 Css NA 0.2114 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046171 Css NA 1.313 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046171 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID2046171 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID2046173 Clint NA 21.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046173 Fup NA 0.1283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046173 Vd NA 2.66 L/kg 1compartment NA NA Human Human +DTXSID2046171 TK.Half.Life NA 1.73 hours 1compartment NA NA Rat Human +DTXSID2046171 Css NA 0.0519 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046171 Css NA 0.1734 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046171 Css NA 0.04272 mg/L PBTK NA 50% Rat Human +DTXSID2046171 Css NA 0.1142 mg/L PBTK NA 95% Rat Human +DTXSID2046173 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046173 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046173 Vd NA 1.593 L/kg 1compartment NA NA Human Human DTXSID2046173 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046173 TK.Half.Life NA 10.28 hours 1compartment NA NA Human Human -DTXSID2046173 Css NA 0.4168 mg/L 3compartmentss NA 50% Human Human -DTXSID2046173 Css NA 2.798 mg/L 3compartmentss NA 95% Human Human -DTXSID2046173 Css NA 0.2962 mg/L PBTK NA 50% Human Human -DTXSID2046173 Css NA 1.871 mg/L PBTK NA 95% Human Human -DTXSID2046173 Clint NA 21.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046173 Fup NA 0.1283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046173 Vd NA 2.045 L/kg 1compartment NA NA Rat Human +DTXSID2046173 TK.Half.Life NA 4.545 hours 1compartment NA NA Human Human +DTXSID2046173 Css NA 0.3058 mg/L 3compartmentss NA 50% Human Human +DTXSID2046173 Css NA 2.286 mg/L 3compartmentss NA 95% Human Human +DTXSID2046173 Css NA 0.2027 mg/L PBTK NA 50% Human Human +DTXSID2046173 Css NA 1.452 mg/L PBTK NA 95% Human Human +DTXSID2046173 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046173 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046173 Vd NA 1.209 L/kg 1compartment NA NA Rat Human DTXSID2046173 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046173 TK.Half.Life NA 2.698 hours 1compartment NA NA Rat Human -DTXSID2046173 Css NA 0.2285 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046173 Css NA 1.153 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046173 Css NA 0.1549 mg/L PBTK NA 50% Rat Human -DTXSID2046173 Css NA 0.7676 mg/L PBTK NA 95% Rat Human -DTXSID2046175 Clint NA 33.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046175 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046175 Vd NA 3.03 L/kg 1compartment NA NA Human Human -DTXSID2046175 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID2046175 TK.Half.Life NA 40.85 hours 1compartment NA NA Human Human -DTXSID2046175 Css NA 1.665 mg/L 3compartmentss NA 50% Human Human -DTXSID2046175 Css NA 10.42 mg/L 3compartmentss NA 95% Human Human -DTXSID2046175 Css NA 1.147 mg/L PBTK NA 50% Human Human -DTXSID2046175 Css NA 6.991 mg/L PBTK NA 95% Human Human -DTXSID2046175 Clint NA 33.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046175 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046175 Vd NA 2.27 L/kg 1compartment NA NA Rat Human -DTXSID2046175 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2046175 TK.Half.Life NA 6.436 hours 1compartment NA NA Rat Human -DTXSID2046175 Css NA 0.9292 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046175 Css NA 5.027 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046175 Css NA 0.6103 mg/L PBTK NA 50% Rat Human -DTXSID2046175 Css NA 3.239 mg/L PBTK NA 95% Rat Human -DTXSID2046177 Clint NA 10.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046177 Fup NA 0.0799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046177 Vd NA 3.123 L/kg 1compartment NA NA Human Human -DTXSID2046177 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID2046177 TK.Half.Life NA 141.2 hours 1compartment NA NA Human Human -DTXSID2046177 Css NA 5.503 mg/L 3compartmentss NA 50% Human Human -DTXSID2046177 Css NA 35.4 mg/L 3compartmentss NA 95% Human Human -DTXSID2046177 Css NA 3.833 mg/L PBTK NA 50% Human Human -DTXSID2046177 Css NA 23.91 mg/L PBTK NA 95% Human Human -DTXSID2046177 Clint NA 10.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046177 Fup NA 0.0799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046177 Vd NA 2.341 L/kg 1compartment NA NA Rat Human -DTXSID2046177 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID2046177 TK.Half.Life NA 18.64 hours 1compartment NA NA Rat Human -DTXSID2046177 Css NA 3.095 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046177 Css NA 16.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046177 Css NA 2.071 mg/L PBTK NA 50% Rat Human -DTXSID2046177 Css NA 10.65 mg/L PBTK NA 95% Rat Human -DTXSID2046179 Clint NA 3.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046179 Fup NA 0.0804 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046179 Vd NA 0.2164 L/kg 1compartment NA NA Human Human +DTXSID2046173 TK.Half.Life NA 1.693 hours 1compartment NA NA Rat Human +DTXSID2046173 Css NA 0.03896 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046173 Css NA 0.2269 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046173 Css NA 0.02564 mg/L PBTK NA 50% Rat Human +DTXSID2046173 Css NA 0.1419 mg/L PBTK NA 95% Rat Human +DTXSID2046175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046175 Fup 0.0241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046175 Vd NA 3.02 L/kg 1compartment NA NA Human Human +DTXSID2046175 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID2046175 TK.Half.Life NA 60.22 hours 1compartment NA NA Human Human +DTXSID2046175 Css NA 2.432 mg/L 3compartmentss NA 50% Human Human +DTXSID2046175 Css NA 16.1 mg/L 3compartmentss NA 95% Human Human +DTXSID2046175 Css NA 1.673 mg/L PBTK NA 50% Human Human +DTXSID2046175 Css NA 10.57 mg/L PBTK NA 95% Human Human +DTXSID2046175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046175 Fup 0.0241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046175 Vd NA 2.262 L/kg 1compartment NA NA Rat Human +DTXSID2046175 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID2046175 TK.Half.Life NA 9.361 hours 1compartment NA NA Rat Human +DTXSID2046175 Css NA 0.3179 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046175 Css NA 1.792 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046175 Css NA 0.2162 mg/L PBTK NA 50% Rat Human +DTXSID2046175 Css NA 1.174 mg/L PBTK NA 95% Rat Human +DTXSID2046177 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046177 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046177 Vd NA 3.127 L/kg 1compartment NA NA Human Human +DTXSID2046177 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID2046177 TK.Half.Life NA 58.94 hours 1compartment NA NA Human Human +DTXSID2046177 Css NA 2.148 mg/L 3compartmentss NA 50% Human Human +DTXSID2046177 Css NA 14.47 mg/L 3compartmentss NA 95% Human Human +DTXSID2046177 Css NA 1.51 mg/L PBTK NA 50% Human Human +DTXSID2046177 Css NA 9.902 mg/L PBTK NA 95% Human Human +DTXSID2046177 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046177 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046177 Vd NA 2.348 L/kg 1compartment NA NA Rat Human +DTXSID2046177 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID2046177 TK.Half.Life NA 8.15 hours 1compartment NA NA Rat Human +DTXSID2046177 Css NA 0.2791 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046177 Css NA 1.539 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046177 Css NA 0.1943 mg/L PBTK NA 50% Rat Human +DTXSID2046177 Css NA 1.045 mg/L PBTK NA 95% Rat Human +DTXSID2046179 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046179 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046179 Vd NA 0.3024 L/kg 1compartment NA NA Human Human DTXSID2046179 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046179 TK.Half.Life NA 2.557 hours 1compartment NA NA Human Human -DTXSID2046179 Css NA 1.957 mg/L 3compartmentss NA 50% Human Human -DTXSID2046179 Css NA 11.65 mg/L 3compartmentss NA 95% Human Human -DTXSID2046179 Css NA 1.174 mg/L PBTK NA 50% Human Human -DTXSID2046179 Css NA 6.821 mg/L PBTK NA 95% Human Human -DTXSID2046179 Clint NA 3.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046179 Fup NA 0.0804 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046179 Vd NA 0.2164 L/kg 1compartment NA NA Rat Human +DTXSID2046179 TK.Half.Life NA 0.9592 hours 1compartment NA NA Human Human +DTXSID2046179 Css NA 0.2776 mg/L 3compartmentss NA 50% Human Human +DTXSID2046179 Css NA 1.721 mg/L 3compartmentss NA 95% Human Human +DTXSID2046179 Css NA 0.179 mg/L PBTK NA 50% Human Human +DTXSID2046179 Css NA 1.064 mg/L PBTK NA 95% Human Human +DTXSID2046179 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046179 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046179 Vd NA 0.3053 L/kg 1compartment NA NA Rat Human DTXSID2046179 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046179 TK.Half.Life NA 1.523 hours 1compartment NA NA Rat Human -DTXSID2046179 Css NA 0.9846 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046179 Css NA 4.539 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046179 Css NA 0.552 mg/L PBTK NA 50% Rat Human -DTXSID2046179 Css NA 2.475 mg/L PBTK NA 95% Rat Human -DTXSID2046200 Clint NA 78.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046200 Fup NA 0.2747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046200 Vd NA 1.436 L/kg 1compartment NA NA Human Human +DTXSID2046179 TK.Half.Life NA 0.5617 hours 1compartment NA NA Rat Human +DTXSID2046179 Css NA 0.01242 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046179 Css NA 0.08598 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046179 Css NA 0.007788 mg/L PBTK NA 50% Rat Human +DTXSID2046179 Css NA 0.05129 mg/L PBTK NA 95% Rat Human +DTXSID2046200 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046200 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046200 Vd NA 2.068 L/kg 1compartment NA NA Human Human DTXSID2046200 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046200 TK.Half.Life NA 1.202 hours 1compartment NA NA Human Human -DTXSID2046200 Css NA 0.01917 mg/L 3compartmentss NA 50% Human Human -DTXSID2046200 Css NA 0.1572 mg/L 3compartmentss NA 95% Human Human -DTXSID2046200 Css NA 0.01568 mg/L PBTK NA 50% Human Human -DTXSID2046200 Css NA 0.112 mg/L PBTK NA 95% Human Human -DTXSID2046200 Clint NA 78.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046200 Fup NA 0.2747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046200 Vd NA 1.438 L/kg 1compartment NA NA Rat Human +DTXSID2046200 TK.Half.Life NA 3.416 hours 1compartment NA NA Human Human +DTXSID2046200 Css NA 0.107 mg/L 3compartmentss NA 50% Human Human +DTXSID2046200 Css NA 0.901 mg/L 3compartmentss NA 95% Human Human +DTXSID2046200 Css NA 0.1038 mg/L PBTK NA 50% Human Human +DTXSID2046200 Css NA 0.688 mg/L PBTK NA 95% Human Human +DTXSID2046200 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046200 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046200 Vd NA 2.086 L/kg 1compartment NA NA Rat Human DTXSID2046200 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046200 TK.Half.Life NA 0.5839 hours 1compartment NA NA Rat Human -DTXSID2046200 Css NA 0.01056 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046200 Css NA 0.0681 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046200 Css NA 0.008336 mg/L PBTK NA 50% Rat Human -DTXSID2046200 Css NA 0.04696 mg/L PBTK NA 95% Rat Human -DTXSID2046202 Clint NA 0.008139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046202 Fup NA 0.545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046202 Vd NA 0.5957 L/kg 1compartment NA NA Human Human +DTXSID2046200 TK.Half.Life NA 1.944 hours 1compartment NA NA Rat Human +DTXSID2046200 Css NA 0.0121 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046200 Css NA 0.0794 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046200 Css NA 0.01209 mg/L PBTK NA 50% Rat Human +DTXSID2046200 Css NA 0.05707 mg/L PBTK NA 95% Rat Human +DTXSID2046202 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046202 Fup 0.859 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046202 Vd NA 0.7799 L/kg 1compartment NA NA Human Human DTXSID2046202 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046202 TK.Half.Life NA 6.97 hours 1compartment NA NA Human Human -DTXSID2046202 Css NA 1.304 mg/L 3compartmentss NA 50% Human Human -DTXSID2046202 Css NA 7.839 mg/L 3compartmentss NA 95% Human Human -DTXSID2046202 Css NA 1.022 mg/L PBTK NA 50% Human Human -DTXSID2046202 Css NA 4.981 mg/L PBTK NA 95% Human Human -DTXSID2046202 Clint NA 0.008139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046202 Fup NA 0.545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046202 Vd NA 0.6144 L/kg 1compartment NA NA Rat Human +DTXSID2046202 TK.Half.Life NA 5.874 hours 1compartment NA NA Human Human +DTXSID2046202 Css NA 0.9032 mg/L 3compartmentss NA 50% Human Human +DTXSID2046202 Css NA 5.645 mg/L 3compartmentss NA 95% Human Human +DTXSID2046202 Css NA 0.765 mg/L PBTK NA 50% Human Human +DTXSID2046202 Css NA 3.635 mg/L PBTK NA 95% Human Human +DTXSID2046202 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046202 Fup 0.859 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046202 Vd NA 0.8062 L/kg 1compartment NA NA Rat Human DTXSID2046202 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046202 TK.Half.Life NA 2.468 hours 1compartment NA NA Rat Human -DTXSID2046202 Css NA 0.3606 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046202 Css NA 2.03 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046202 Css NA 0.2683 mg/L PBTK NA 50% Rat Human -DTXSID2046202 Css NA 1.19 mg/L PBTK NA 95% Rat Human -DTXSID2046206 Clint NA 12.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046206 Fup NA 0.0399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046206 Vd NA 0.7458 L/kg 1compartment NA NA Human Human +DTXSID2046202 TK.Half.Life NA 2.069 hours 1compartment NA NA Rat Human +DTXSID2046202 Css NA 0.05306 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046202 Css NA 0.3162 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046202 Css NA 0.04533 mg/L PBTK NA 50% Rat Human +DTXSID2046202 Css NA 0.1981 mg/L PBTK NA 95% Rat Human +DTXSID2046206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046206 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046206 Vd NA 1.555 L/kg 1compartment NA NA Human Human DTXSID2046206 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046206 TK.Half.Life NA 5.899 hours 1compartment NA NA Human Human -DTXSID2046206 Css NA 1.296 mg/L 3compartmentss NA 50% Human Human -DTXSID2046206 Css NA 11.45 mg/L 3compartmentss NA 95% Human Human -DTXSID2046206 Css NA 0.7967 mg/L PBTK NA 50% Human Human -DTXSID2046206 Css NA 6.825 mg/L PBTK NA 95% Human Human -DTXSID2046206 Clint NA 12.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046206 Fup NA 0.0399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046206 Vd NA 0.5774 L/kg 1compartment NA NA Rat Human +DTXSID2046206 TK.Half.Life NA 2.997 hours 1compartment NA NA Human Human +DTXSID2046206 Css NA 0.1427 mg/L 3compartmentss NA 50% Human Human +DTXSID2046206 Css NA 1.005 mg/L 3compartmentss NA 95% Human Human +DTXSID2046206 Css NA 0.1011 mg/L PBTK NA 50% Human Human +DTXSID2046206 Css NA 0.675 mg/L PBTK NA 95% Human Human +DTXSID2046206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046206 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046206 Vd NA 1.219 L/kg 1compartment NA NA Rat Human DTXSID2046206 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046206 TK.Half.Life NA 2.779 hours 1compartment NA NA Rat Human -DTXSID2046206 Css NA 0.7238 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046206 Css NA 4.883 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046206 Css NA 0.4136 mg/L PBTK NA 50% Rat Human -DTXSID2046206 Css NA 2.689 mg/L PBTK NA 95% Rat Human -DTXSID2046208 Clint NA 0.3254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046208 Fup NA 0.1122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046208 Vd NA 0.2919 L/kg 1compartment NA NA Human Human -DTXSID2046208 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2046208 TK.Half.Life NA 10.92 hours 1compartment NA NA Human Human -DTXSID2046208 Css NA 5.578 mg/L 3compartmentss NA 50% Human Human -DTXSID2046208 Css NA 27.48 mg/L 3compartmentss NA 95% Human Human -DTXSID2046208 Css NA 3.484 mg/L PBTK NA 50% Human Human -DTXSID2046208 Css NA 16.2 mg/L PBTK NA 95% Human Human -DTXSID2046208 Clint NA 0.3254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046208 Fup NA 0.1122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046208 Vd NA 0.2915 L/kg 1compartment NA NA Rat Human +DTXSID2046206 TK.Half.Life NA 1.159 hours 1compartment NA NA Rat Human +DTXSID2046206 Css NA 0.01828 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046206 Css NA 0.09688 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046206 Css NA 0.01284 mg/L PBTK NA 50% Rat Human +DTXSID2046206 Css NA 0.06439 mg/L PBTK NA 95% Rat Human +DTXSID2046208 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046208 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046208 Vd NA 0.9229 L/kg 1compartment NA NA Human Human +DTXSID2046208 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046208 TK.Half.Life NA 2.447 hours 1compartment NA NA Human Human +DTXSID2046208 Css NA 0.232 mg/L 3compartmentss NA 50% Human Human +DTXSID2046208 Css NA 1.445 mg/L 3compartmentss NA 95% Human Human +DTXSID2046208 Css NA 0.169 mg/L PBTK NA 50% Human Human +DTXSID2046208 Css NA 0.9678 mg/L PBTK NA 95% Human Human +DTXSID2046208 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046208 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046208 Vd NA 0.8015 L/kg 1compartment NA NA Rat Human DTXSID2046208 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046208 TK.Half.Life NA 4.533 hours 1compartment NA NA Rat Human -DTXSID2046208 Css NA 1.986 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046208 Css NA 7.983 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046208 Css NA 1.156 mg/L PBTK NA 50% Rat Human -DTXSID2046208 Css NA 4.402 mg/L PBTK NA 95% Rat Human -DTXSID2046250 Clint NA 29.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046250 Fup NA 0.0176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046250 Vd NA 1.145 L/kg 1compartment NA NA Human Human +DTXSID2046208 TK.Half.Life NA 1.177 hours 1compartment NA NA Rat Human +DTXSID2046208 Css NA 0.02751 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046208 Css NA 0.1296 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046208 Css NA 0.02002 mg/L PBTK NA 50% Rat Human +DTXSID2046208 Css NA 0.08452 mg/L PBTK NA 95% Rat Human +DTXSID2046250 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046250 Fup 0.0356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046250 Vd NA 1.55 L/kg 1compartment NA NA Human Human DTXSID2046250 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046250 TK.Half.Life NA 8.543 hours 1compartment NA NA Human Human -DTXSID2046250 Css NA 1.198 mg/L 3compartmentss NA 50% Human Human -DTXSID2046250 Css NA 11.23 mg/L 3compartmentss NA 95% Human Human -DTXSID2046250 Css NA 0.7365 mg/L PBTK NA 50% Human Human -DTXSID2046250 Css NA 6.639 mg/L PBTK NA 95% Human Human -DTXSID2046250 Clint NA 29.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046250 Fup NA 0.0176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046250 Vd NA 0.8507 L/kg 1compartment NA NA Rat Human +DTXSID2046250 TK.Half.Life NA 9.441 hours 1compartment NA NA Human Human +DTXSID2046250 Css NA 0.8894 mg/L 3compartmentss NA 50% Human Human +DTXSID2046250 Css NA 6.552 mg/L 3compartmentss NA 95% Human Human +DTXSID2046250 Css NA 0.5634 mg/L PBTK NA 50% Human Human +DTXSID2046250 Css NA 4.027 mg/L PBTK NA 95% Human Human +DTXSID2046250 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046250 Fup 0.0356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046250 Vd NA 1.16 L/kg 1compartment NA NA Rat Human DTXSID2046250 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046250 TK.Half.Life NA 3.621 hours 1compartment NA NA Rat Human -DTXSID2046250 Css NA 0.6696 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046250 Css NA 5.216 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046250 Css NA 0.385 mg/L PBTK NA 50% Rat Human -DTXSID2046250 Css NA 2.886 mg/L PBTK NA 95% Rat Human -DTXSID2046252 Clint NA 11.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046252 Fup NA 0.085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046252 Vd NA 2.544 L/kg 1compartment NA NA Human Human +DTXSID2046250 TK.Half.Life NA 3.595 hours 1compartment NA NA Rat Human +DTXSID2046250 Css NA 0.1139 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046250 Css NA 0.6842 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046250 Css NA 0.07009 mg/L PBTK NA 50% Rat Human +DTXSID2046250 Css NA 0.41 mg/L PBTK NA 95% Rat Human +DTXSID2046252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046252 Fup 0.08 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046252 Vd NA 2.762 L/kg 1compartment NA NA Human Human DTXSID2046252 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2046252 TK.Half.Life NA 20.51 hours 1compartment NA NA Human Human -DTXSID2046252 Css NA 1.024 mg/L 3compartmentss NA 50% Human Human -DTXSID2046252 Css NA 6.54 mg/L 3compartmentss NA 95% Human Human -DTXSID2046252 Css NA 0.7154 mg/L PBTK NA 50% Human Human -DTXSID2046252 Css NA 4.343 mg/L PBTK NA 95% Human Human -DTXSID2046252 Clint NA 11.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046252 Fup NA 0.085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046252 Vd NA 1.955 L/kg 1compartment NA NA Rat Human -DTXSID2046252 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2046252 TK.Half.Life NA 5.497 hours 1compartment NA NA Rat Human -DTXSID2046252 Css NA 0.5582 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046252 Css NA 2.695 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046252 Css NA 0.3684 mg/L PBTK NA 50% Rat Human -DTXSID2046252 Css NA 1.685 mg/L PBTK NA 95% Rat Human -DTXSID2046256 Clint NA 4.887 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046256 Fup NA 0.4426 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046256 Vd NA 0.8154 L/kg 1compartment NA NA Human Human +DTXSID2046252 TK.Half.Life NA 16.82 hours 1compartment NA NA Human Human +DTXSID2046252 Css NA 0.6986 mg/L 3compartmentss NA 50% Human Human +DTXSID2046252 Css NA 4.586 mg/L 3compartmentss NA 95% Human Human +DTXSID2046252 Css NA 0.4846 mg/L PBTK NA 50% Human Human +DTXSID2046252 Css NA 3.07 mg/L PBTK NA 95% Human Human +DTXSID2046252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046252 Fup 0.08 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046252 Vd NA 2.105 L/kg 1compartment NA NA Rat Human +DTXSID2046252 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2046252 TK.Half.Life NA 3.918 hours 1compartment NA NA Rat Human +DTXSID2046252 Css NA 0.09015 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046252 Css NA 0.4717 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046252 Css NA 0.06226 mg/L PBTK NA 50% Rat Human +DTXSID2046252 Css NA 0.3106 mg/L PBTK NA 95% Rat Human +DTXSID2046254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046254 Fup 0.0115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046254 Vd NA 2.593 L/kg 1compartment NA NA Human Human +DTXSID2046254 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID2046254 TK.Half.Life NA 44.72 hours 1compartment NA NA Human Human +DTXSID2046254 Css NA 2.399 mg/L 3compartmentss NA 50% Human Human +DTXSID2046254 Css NA 17.57 mg/L 3compartmentss NA 95% Human Human +DTXSID2046254 Css NA 1.592 mg/L PBTK NA 50% Human Human +DTXSID2046254 Css NA 11.3 mg/L PBTK NA 95% Human Human +DTXSID2046254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046254 Fup 0.0115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046254 Vd NA 1.934 L/kg 1compartment NA NA Rat Human +DTXSID2046254 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID2046254 TK.Half.Life NA 10.28 hours 1compartment NA NA Rat Human +DTXSID2046254 Css NA 0.3103 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046254 Css NA 1.986 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046254 Css NA 0.2016 mg/L PBTK NA 50% Rat Human +DTXSID2046254 Css NA 1.25 mg/L PBTK NA 95% Rat Human +DTXSID2046256 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046256 Fup 0.384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046256 Vd NA 0.7511 L/kg 1compartment NA NA Human Human DTXSID2046256 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046256 TK.Half.Life NA 1.777 hours 1compartment NA NA Human Human -DTXSID2046256 Css NA 0.187 mg/L 3compartmentss NA 50% Human Human -DTXSID2046256 Css NA 1.228 mg/L 3compartmentss NA 95% Human Human -DTXSID2046256 Css NA 0.145 mg/L PBTK NA 50% Human Human -DTXSID2046256 Css NA 0.8292 mg/L PBTK NA 95% Human Human -DTXSID2046256 Clint NA 4.887 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046256 Fup NA 0.4426 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046256 Vd NA 0.7647 L/kg 1compartment NA NA Rat Human +DTXSID2046256 TK.Half.Life NA 1.576 hours 1compartment NA NA Human Human +DTXSID2046256 Css NA 0.1676 mg/L 3compartmentss NA 50% Human Human +DTXSID2046256 Css NA 1.083 mg/L 3compartmentss NA 95% Human Human +DTXSID2046256 Css NA 0.1258 mg/L PBTK NA 50% Human Human +DTXSID2046256 Css NA 0.7275 mg/L PBTK NA 95% Human Human +DTXSID2046256 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046256 Fup 0.384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046256 Vd NA 0.7038 L/kg 1compartment NA NA Rat Human DTXSID2046256 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046256 TK.Half.Life NA 0.9159 hours 1compartment NA NA Rat Human -DTXSID2046256 Css NA 0.08997 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046256 Css NA 0.4749 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046256 Css NA 0.06779 mg/L PBTK NA 50% Rat Human -DTXSID2046256 Css NA 0.2936 mg/L PBTK NA 95% Rat Human -DTXSID2046258 Clint NA 28.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046258 Fup NA 0.0916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046258 Vd NA 1.566 L/kg 1compartment NA NA Human Human +DTXSID2046256 TK.Half.Life NA 0.8203 hours 1compartment NA NA Rat Human +DTXSID2046256 Css NA 0.01943 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046256 Css NA 0.09884 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046256 Css NA 0.01455 mg/L PBTK NA 50% Rat Human +DTXSID2046256 Css NA 0.06431 mg/L PBTK NA 95% Rat Human +DTXSID2046258 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046258 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046258 Vd NA 2.041 L/kg 1compartment NA NA Human Human DTXSID2046258 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046258 TK.Half.Life NA 3.148 hours 1compartment NA NA Human Human -DTXSID2046258 Css NA 0.1904 mg/L 3compartmentss NA 50% Human Human -DTXSID2046258 Css NA 1.671 mg/L 3compartmentss NA 95% Human Human -DTXSID2046258 Css NA 0.1392 mg/L PBTK NA 50% Human Human -DTXSID2046258 Css NA 1.107 mg/L PBTK NA 95% Human Human -DTXSID2046258 Clint NA 28.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046258 Fup NA 0.0916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046258 Vd NA 1.54 L/kg 1compartment NA NA Rat Human +DTXSID2046258 TK.Half.Life NA 3.551 hours 1compartment NA NA Human Human +DTXSID2046258 Css NA 0.1342 mg/L 3compartmentss NA 50% Human Human +DTXSID2046258 Css NA 1.175 mg/L 3compartmentss NA 95% Human Human +DTXSID2046258 Css NA 0.11 mg/L PBTK NA 50% Human Human +DTXSID2046258 Css NA 0.8285 mg/L PBTK NA 95% Human Human +DTXSID2046258 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046258 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046258 Vd NA 2.023 L/kg 1compartment NA NA Rat Human DTXSID2046258 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046258 TK.Half.Life NA 1.817 hours 1compartment NA NA Rat Human -DTXSID2046258 Css NA 0.1059 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046258 Css NA 0.7356 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046258 Css NA 0.07372 mg/L PBTK NA 50% Rat Human -DTXSID2046258 Css NA 0.4592 mg/L PBTK NA 95% Rat Human -DTXSID2046383 Clint NA 77.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046383 Fup NA 0.3321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046383 Vd NA 0.4763 L/kg 1compartment NA NA Human Human +DTXSID2046258 TK.Half.Life NA 2.037 hours 1compartment NA NA Rat Human +DTXSID2046258 Css NA 0.01686 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046258 Css NA 0.1222 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046258 Css NA 0.01372 mg/L PBTK NA 50% Rat Human +DTXSID2046258 Css NA 0.08281 mg/L PBTK NA 95% Rat Human +DTXSID2046383 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046383 Fup 0.544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046383 Vd NA 0.6075 L/kg 1compartment NA NA Human Human DTXSID2046383 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046383 TK.Half.Life NA 0.4362 hours 1compartment NA NA Human Human -DTXSID2046383 Css NA 0.01897 mg/L 3compartmentss NA 50% Human Human -DTXSID2046383 Css NA 0.1494 mg/L 3compartmentss NA 95% Human Human -DTXSID2046383 Css NA 0.01322 mg/L PBTK NA 50% Human Human -DTXSID2046383 Css NA 0.09835 mg/L PBTK NA 95% Human Human -DTXSID2046383 Clint NA 77.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046383 Fup NA 0.3321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046383 Vd NA 0.4808 L/kg 1compartment NA NA Rat Human +DTXSID2046383 TK.Half.Life NA 7.243 hours 1compartment NA NA Human Human +DTXSID2046383 Css NA 1.322 mg/L 3compartmentss NA 50% Human Human +DTXSID2046383 Css NA 8.392 mg/L 3compartmentss NA 95% Human Human +DTXSID2046383 Css NA 1.015 mg/L PBTK NA 50% Human Human +DTXSID2046383 Css NA 5.223 mg/L PBTK NA 95% Human Human +DTXSID2046383 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046383 Fup 0.544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046383 Vd NA 0.6192 L/kg 1compartment NA NA Rat Human DTXSID2046383 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046383 TK.Half.Life NA 0.2074 hours 1compartment NA NA Rat Human -DTXSID2046383 Css NA 0.01048 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046383 Css NA 0.06532 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046383 Css NA 0.006988 mg/L PBTK NA 50% Rat Human -DTXSID2046383 Css NA 0.04088 mg/L PBTK NA 95% Rat Human -DTXSID2046385 Clint NA 129.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046385 Fup NA 0.1971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046385 Vd NA 1.194 L/kg 1compartment NA NA Human Human +DTXSID2046383 TK.Half.Life NA 2.511 hours 1compartment NA NA Rat Human +DTXSID2046383 Css NA 0.08242 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046383 Css NA 0.461 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046383 Css NA 0.06285 mg/L PBTK NA 50% Rat Human +DTXSID2046383 Css NA 0.2788 mg/L PBTK NA 95% Rat Human +DTXSID2046385 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046385 Fup 0.419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046385 Vd NA 1.305 L/kg 1compartment NA NA Human Human DTXSID2046385 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046385 TK.Half.Life NA 1.125 hours 1compartment NA NA Human Human -DTXSID2046385 Css NA 0.02094 mg/L 3compartmentss NA 50% Human Human -DTXSID2046385 Css NA 0.1494 mg/L 3compartmentss NA 95% Human Human -DTXSID2046385 Css NA 0.01483 mg/L PBTK NA 50% Human Human -DTXSID2046385 Css NA 0.09957 mg/L PBTK NA 95% Human Human -DTXSID2046385 Clint NA 129.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046385 Fup NA 0.1971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046385 Vd NA 0.9674 L/kg 1compartment NA NA Rat Human +DTXSID2046385 TK.Half.Life NA 2.693 hours 1compartment NA NA Human Human +DTXSID2046385 Css NA 0.1584 mg/L 3compartmentss NA 50% Human Human +DTXSID2046385 Css NA 1.056 mg/L 3compartmentss NA 95% Human Human +DTXSID2046385 Css NA 0.1282 mg/L PBTK NA 50% Human Human +DTXSID2046385 Css NA 0.7401 mg/L PBTK NA 95% Human Human +DTXSID2046385 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046385 Fup 0.419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046385 Vd NA 1.116 L/kg 1compartment NA NA Rat Human DTXSID2046385 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046385 TK.Half.Life NA 0.4232 hours 1compartment NA NA Rat Human -DTXSID2046385 Css NA 0.01157 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046385 Css NA 0.06594 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046385 Css NA 0.007876 mg/L PBTK NA 50% Rat Human -DTXSID2046385 Css NA 0.0427 mg/L PBTK NA 95% Rat Human -DTXSID2046389 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046389 Fup NA 0.4714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046389 Vd NA 0.5664 L/kg 1compartment NA NA Human Human +DTXSID2046385 TK.Half.Life NA 1.201 hours 1compartment NA NA Rat Human +DTXSID2046385 Css NA 0.01851 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046385 Css NA 0.09176 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046385 Css NA 0.01491 mg/L PBTK NA 50% Rat Human +DTXSID2046385 Css NA 0.06188 mg/L PBTK NA 95% Rat Human +DTXSID2046389 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046389 Fup 0.59 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046389 Vd NA 0.6745 L/kg 1compartment NA NA Human Human DTXSID2046389 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046389 TK.Half.Life NA 7.813 hours 1compartment NA NA Human Human -DTXSID2046389 Css NA 1.567 mg/L 3compartmentss NA 50% Human Human -DTXSID2046389 Css NA 7.43 mg/L 3compartmentss NA 95% Human Human -DTXSID2046389 Css NA 1.163 mg/L PBTK NA 50% Human Human -DTXSID2046389 Css NA 4.693 mg/L PBTK NA 95% Human Human -DTXSID2046389 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046389 Fup NA 0.4714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046389 Vd NA 0.5623 L/kg 1compartment NA NA Rat Human +DTXSID2046389 TK.Half.Life NA 0.9916 hours 1compartment NA NA Human Human +DTXSID2046389 Css NA 0.0531 mg/L 3compartmentss NA 50% Human Human +DTXSID2046389 Css NA 0.5623 mg/L 3compartmentss NA 95% Human Human +DTXSID2046389 Css NA 0.04244 mg/L PBTK NA 50% Human Human +DTXSID2046389 Css NA 0.3781 mg/L PBTK NA 95% Human Human +DTXSID2046389 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046389 Fup 0.59 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046389 Vd NA 0.6922 L/kg 1compartment NA NA Rat Human DTXSID2046389 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046389 TK.Half.Life NA 2.634 hours 1compartment NA NA Rat Human -DTXSID2046389 Css NA 0.4303 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046389 Css NA 1.804 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046389 Css NA 0.3042 mg/L PBTK NA 50% Rat Human -DTXSID2046389 Css NA 1.06 mg/L PBTK NA 95% Rat Human -DTXSID2046410 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046410 Fup NA 0.7709 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046410 Vd NA 0.5932 L/kg 1compartment NA NA Human Human +DTXSID2046389 TK.Half.Life NA 0.551 hours 1compartment NA NA Rat Human +DTXSID2046389 Css NA 0.0004814 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046389 Css NA 0.00497 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046389 Css NA 0.0003718 mg/L PBTK NA 50% Rat Human +DTXSID2046389 Css NA 0.003113 mg/L PBTK NA 95% Rat Human +DTXSID2046410 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046410 Fup 0.861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046410 Vd NA 0.641 L/kg 1compartment NA NA Human Human DTXSID2046410 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046410 TK.Half.Life NA 4.98 hours 1compartment NA NA Human Human -DTXSID2046410 Css NA 1.065 mg/L 3compartmentss NA 50% Human Human -DTXSID2046410 Css NA 6.555 mg/L 3compartmentss NA 95% Human Human -DTXSID2046410 Css NA 0.8348 mg/L PBTK NA 50% Human Human -DTXSID2046410 Css NA 4.133 mg/L PBTK NA 95% Human Human -DTXSID2046410 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046410 Fup NA 0.7709 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046410 Vd NA 0.6279 L/kg 1compartment NA NA Rat Human +DTXSID2046410 TK.Half.Life NA 4.817 hours 1compartment NA NA Human Human +DTXSID2046410 Css NA 0.9492 mg/L 3compartmentss NA 50% Human Human +DTXSID2046410 Css NA 5.589 mg/L 3compartmentss NA 95% Human Human +DTXSID2046410 Css NA 0.7572 mg/L PBTK NA 50% Human Human +DTXSID2046410 Css NA 3.609 mg/L PBTK NA 95% Human Human +DTXSID2046410 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046410 Fup 0.861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046410 Vd NA 0.677 L/kg 1compartment NA NA Rat Human DTXSID2046410 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046410 TK.Half.Life NA 1.796 hours 1compartment NA NA Rat Human -DTXSID2046410 Css NA 0.2722 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046410 Css NA 1.697 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046410 Css NA 0.2057 mg/L PBTK NA 50% Rat Human -DTXSID2046410 Css NA 0.992 mg/L PBTK NA 95% Rat Human +DTXSID2046410 TK.Half.Life NA 1.733 hours 1compartment NA NA Rat Human +DTXSID2046410 Css NA 0.05702 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046410 Css NA 0.3182 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046410 Css NA 0.04545 mg/L PBTK NA 50% Rat Human +DTXSID2046410 Css NA 0.1956 mg/L PBTK NA 95% Rat Human DTXSID2046412 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2046412 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2046412 Vd NA 0.6826 L/kg 1compartment NA NA Human Human DTXSID2046412 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2046412 TK.Half.Life NA 4.418 hours 1compartment NA NA Human Human -DTXSID2046412 Css NA 0.8514 mg/L 3compartmentss NA 50% Human Human -DTXSID2046412 Css NA 5.58 mg/L 3compartmentss NA 95% Human Human -DTXSID2046412 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID2046412 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID2046412 Css NA 0.7174 mg/L 3compartmentss NA 50% Human Human +DTXSID2046412 Css NA 5.075 mg/L 3compartmentss NA 95% Human Human +DTXSID2046412 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID2046412 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID2046412 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2046412 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2046412 Vd NA 0.7357 L/kg 1compartment NA NA Rat Human DTXSID2046412 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2046412 TK.Half.Life NA 1.622 hours 1compartment NA NA Rat Human -DTXSID2046412 Css NA 0.2139 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046412 Css NA 1.341 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046412 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID2046412 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID2046412 Css NA 0.01317 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046412 Css NA 0.1004 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046412 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID2046412 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID2046418 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2046418 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046418 Vd NA 1.15 L/kg 1compartment NA NA Human Human +DTXSID2046418 Vd NA 0.6456 L/kg 1compartment NA NA Human Human DTXSID2046418 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046418 TK.Half.Life NA 7.443 hours 1compartment NA NA Human Human -DTXSID2046418 Css NA 0.7537 mg/L 3compartmentss NA 50% Human Human -DTXSID2046418 Css NA 5.368 mg/L 3compartmentss NA 95% Human Human -DTXSID2046418 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID2046418 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID2046418 TK.Half.Life NA 4.178 hours 1compartment NA NA Human Human +DTXSID2046418 Css NA 0.7243 mg/L 3compartmentss NA 50% Human Human +DTXSID2046418 Css NA 5.098 mg/L 3compartmentss NA 95% Human Human +DTXSID2046418 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID2046418 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID2046418 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2046418 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046418 Vd NA 1.236 L/kg 1compartment NA NA Rat Human +DTXSID2046418 Vd NA 0.7051 L/kg 1compartment NA NA Rat Human DTXSID2046418 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046418 TK.Half.Life NA 2.725 hours 1compartment NA NA Rat Human -DTXSID2046418 Css NA 0.1871 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046418 Css NA 1.287 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046418 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID2046418 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID2046460 Clint NA 0.8857 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046460 Fup NA 0.1089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046460 Vd NA 1.226 L/kg 1compartment NA NA Human Human +DTXSID2046418 TK.Half.Life NA 1.554 hours 1compartment NA NA Rat Human +DTXSID2046418 Css NA 0.01331 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046418 Css NA 0.101 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046418 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID2046418 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID2046460 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046460 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046460 Vd NA 1.074 L/kg 1compartment NA NA Human Human DTXSID2046460 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2046460 TK.Half.Life NA 34.06 hours 1compartment NA NA Human Human -DTXSID2046460 Css NA 3.992 mg/L 3compartmentss NA 50% Human Human -DTXSID2046460 Css NA 20.15 mg/L 3compartmentss NA 95% Human Human -DTXSID2046460 Css NA 2.636 mg/L PBTK NA 50% Human Human -DTXSID2046460 Css NA 12.1 mg/L PBTK NA 95% Human Human -DTXSID2046460 Clint NA 0.8857 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046460 Fup NA 0.1089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046460 Vd NA 0.9505 L/kg 1compartment NA NA Rat Human -DTXSID2046460 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2046460 TK.Half.Life NA 11.3 hours 1compartment NA NA Rat Human -DTXSID2046460 Css NA 1.647 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046460 Css NA 6.516 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046460 Css NA 1.021 mg/L PBTK NA 50% Rat Human -DTXSID2046460 Css NA 3.683 mg/L PBTK NA 95% Rat Human +DTXSID2046460 TK.Half.Life NA 31.87 hours 1compartment NA NA Human Human +DTXSID2046460 Css NA 3.25 mg/L 3compartmentss NA 50% Human Human +DTXSID2046460 Css NA 11.96 mg/L 3compartmentss NA 95% Human Human +DTXSID2046460 Css NA 2.344 mg/L PBTK NA 50% Human Human +DTXSID2046460 Css NA 7.594 mg/L PBTK NA 95% Human Human +DTXSID2046460 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046460 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046460 Vd NA 0.8876 L/kg 1compartment NA NA Rat Human +DTXSID2046460 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2046460 TK.Half.Life NA 8.199 hours 1compartment NA NA Rat Human +DTXSID2046460 Css NA 0.2077 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046460 Css NA 0.6677 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046460 Css NA 0.148 mg/L PBTK NA 50% Rat Human +DTXSID2046460 Css NA 0.4099 mg/L PBTK NA 95% Rat Human DTXSID2046462 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2046462 Fup NA 0.9694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046462 Vd NA 0.782 L/kg 1compartment NA NA Human Human +DTXSID2046462 Vd NA 0.81 L/kg 1compartment NA NA Human Human DTXSID2046462 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046462 TK.Half.Life NA 5.223 hours 1compartment NA NA Human Human -DTXSID2046462 Css NA 0.8784 mg/L 3compartmentss NA 50% Human Human -DTXSID2046462 Css NA 5.102 mg/L 3compartmentss NA 95% Human Human -DTXSID2046462 Css NA 0.734 mg/L PBTK NA 50% Human Human -DTXSID2046462 Css NA 3.316 mg/L PBTK NA 95% Human Human +DTXSID2046462 TK.Half.Life NA 5.411 hours 1compartment NA NA Human Human +DTXSID2046462 Css NA 0.751 mg/L 3compartmentss NA 50% Human Human +DTXSID2046462 Css NA 4.311 mg/L 3compartmentss NA 95% Human Human +DTXSID2046462 Css NA 0.627 mg/L PBTK NA 50% Human Human +DTXSID2046462 Css NA 2.793 mg/L PBTK NA 95% Human Human DTXSID2046462 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2046462 Fup NA 0.9694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046462 Vd NA 0.8268 L/kg 1compartment NA NA Rat Human +DTXSID2046462 Vd NA 0.8509 L/kg 1compartment NA NA Rat Human DTXSID2046462 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046462 TK.Half.Life NA 1.88 hours 1compartment NA NA Rat Human -DTXSID2046462 Css NA 0.2249 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046462 Css NA 1.222 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046462 Css NA 0.182 mg/L PBTK NA 50% Rat Human -DTXSID2046462 Css NA 0.7408 mg/L PBTK NA 95% Rat Human -DTXSID2046464 Clint NA 4.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046464 Fup NA 0.2571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046464 Vd NA 1.209 L/kg 1compartment NA NA Human Human +DTXSID2046462 TK.Half.Life NA 1.935 hours 1compartment NA NA Rat Human +DTXSID2046462 Css NA 0.01416 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046462 Css NA 0.1012 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046462 Css NA 0.01132 mg/L PBTK NA 50% Rat Human +DTXSID2046462 Css NA 0.06748 mg/L PBTK NA 95% Rat Human +DTXSID2046464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046464 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046464 Vd NA 1.325 L/kg 1compartment NA NA Human Human DTXSID2046464 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046464 TK.Half.Life NA 4.472 hours 1compartment NA NA Human Human -DTXSID2046464 Css NA 0.3682 mg/L 3compartmentss NA 50% Human Human -DTXSID2046464 Css NA 2.029 mg/L 3compartmentss NA 95% Human Human -DTXSID2046464 Css NA 0.2687 mg/L PBTK NA 50% Human Human -DTXSID2046464 Css NA 1.368 mg/L PBTK NA 95% Human Human -DTXSID2046464 Clint NA 4.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046464 Fup NA 0.2571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046464 Vd NA 0.9932 L/kg 1compartment NA NA Rat Human +DTXSID2046464 TK.Half.Life NA 1.763 hours 1compartment NA NA Human Human +DTXSID2046464 Css NA 0.07087 mg/L 3compartmentss NA 50% Human Human +DTXSID2046464 Css NA 0.5309 mg/L 3compartmentss NA 95% Human Human +DTXSID2046464 Css NA 0.05324 mg/L PBTK NA 50% Human Human +DTXSID2046464 Css NA 0.3697 mg/L PBTK NA 95% Human Human +DTXSID2046464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046464 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046464 Vd NA 1.09 L/kg 1compartment NA NA Rat Human DTXSID2046464 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046464 TK.Half.Life NA 1.941 hours 1compartment NA NA Rat Human -DTXSID2046464 Css NA 0.1825 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046464 Css NA 0.7738 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046464 Css NA 0.1282 mg/L PBTK NA 50% Rat Human -DTXSID2046464 Css NA 0.4853 mg/L PBTK NA 95% Rat Human -DTXSID2046468 Clint NA 14.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046468 Fup NA 0.1056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046468 Vd NA 1.4 L/kg 1compartment NA NA Human Human -DTXSID2046468 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046468 TK.Half.Life NA 5.104 hours 1compartment NA NA Human Human -DTXSID2046468 Css NA 0.447 mg/L 3compartmentss NA 50% Human Human -DTXSID2046468 Css NA 3.263 mg/L 3compartmentss NA 95% Human Human -DTXSID2046468 Css NA 0.2988 mg/L PBTK NA 50% Human Human -DTXSID2046468 Css NA 2.077 mg/L PBTK NA 95% Human Human -DTXSID2046468 Clint NA 14.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046468 Fup NA 0.1056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046468 Vd NA 1.082 L/kg 1compartment NA NA Rat Human +DTXSID2046464 TK.Half.Life NA 0.7265 hours 1compartment NA NA Rat Human +DTXSID2046464 Css NA 0.008893 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046464 Css NA 0.04982 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046464 Css NA 0.0067 mg/L PBTK NA 50% Rat Human +DTXSID2046464 Css NA 0.03408 mg/L PBTK NA 95% Rat Human +DTXSID2046468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046468 Fup 0.051 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046468 Vd NA 2.298 L/kg 1compartment NA NA Human Human +DTXSID2046468 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2046468 TK.Half.Life NA 14.11 hours 1compartment NA NA Human Human +DTXSID2046468 Css NA 0.7892 mg/L 3compartmentss NA 50% Human Human +DTXSID2046468 Css NA 5.395 mg/L 3compartmentss NA 95% Human Human +DTXSID2046468 Css NA 0.5247 mg/L PBTK NA 50% Human Human +DTXSID2046468 Css NA 3.44 mg/L PBTK NA 95% Human Human +DTXSID2046468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046468 Fup 0.051 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046468 Vd NA 1.724 L/kg 1compartment NA NA Rat Human DTXSID2046468 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046468 TK.Half.Life NA 2.062 hours 1compartment NA NA Rat Human -DTXSID2046468 Css NA 0.2442 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046468 Css NA 1.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046468 Css NA 0.153 mg/L PBTK NA 50% Rat Human -DTXSID2046468 Css NA 0.7803 mg/L PBTK NA 95% Rat Human -DTXSID2046541 Clint NA 26.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046541 Fup NA 0.3855 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046541 Vd NA 1.117 L/kg 1compartment NA NA Human Human -DTXSID2046541 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046541 TK.Half.Life NA 1.19 hours 1compartment NA NA Human Human -DTXSID2046541 Css NA 0.04603 mg/L 3compartmentss NA 50% Human Human -DTXSID2046541 Css NA 0.3371 mg/L 3compartmentss NA 95% Human Human -DTXSID2046541 Css NA 0.03599 mg/L PBTK NA 50% Human Human -DTXSID2046541 Css NA 0.2423 mg/L PBTK NA 95% Human Human -DTXSID2046541 Clint NA 26.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046541 Fup NA 0.3855 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046541 Vd NA 0.9666 L/kg 1compartment NA NA Rat Human -DTXSID2046541 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046541 TK.Half.Life NA 0.5127 hours 1compartment NA NA Rat Human -DTXSID2046541 Css NA 0.02447 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046541 Css NA 0.144 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046541 Css NA 0.01832 mg/L PBTK NA 50% Rat Human -DTXSID2046541 Css NA 0.09633 mg/L PBTK NA 95% Rat Human -DTXSID2046543 Clint NA 0.1217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046543 Fup NA 0.5194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046543 Vd NA 0.5496 L/kg 1compartment NA NA Human Human +DTXSID2046468 TK.Half.Life NA 4.032 hours 1compartment NA NA Rat Human +DTXSID2046468 Css NA 0.101 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046468 Css NA 0.5871 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046468 Css NA 0.06592 mg/L PBTK NA 50% Rat Human +DTXSID2046468 Css NA 0.3692 mg/L PBTK NA 95% Rat Human +DTXSID2046541 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046541 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046541 Vd NA 1.819 L/kg 1compartment NA NA Human Human +DTXSID2046541 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID2046541 TK.Half.Life NA 59.24 hours 1compartment NA NA Human Human +DTXSID2046541 Css NA 3.39 mg/L 3compartmentss NA 50% Human Human +DTXSID2046541 Css NA 11.89 mg/L 3compartmentss NA 95% Human Human +DTXSID2046541 Css NA 2.607 mg/L PBTK NA 50% Human Human +DTXSID2046541 Css NA 8.002 mg/L PBTK NA 95% Human Human +DTXSID2046541 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046541 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046541 Vd NA 1.441 L/kg 1compartment NA NA Rat Human +DTXSID2046541 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2046541 TK.Half.Life NA 11.88 hours 1compartment NA NA Rat Human +DTXSID2046541 Css NA 0.2162 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046541 Css NA 0.6282 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046541 Css NA 0.1646 mg/L PBTK NA 50% Rat Human +DTXSID2046541 Css NA 0.4031 mg/L PBTK NA 95% Rat Human +DTXSID2046543 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046543 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046543 Vd NA 0.5779 L/kg 1compartment NA NA Human Human DTXSID2046543 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046543 TK.Half.Life NA 5.599 hours 1compartment NA NA Human Human -DTXSID2046543 Css NA 1.122 mg/L 3compartmentss NA 50% Human Human -DTXSID2046543 Css NA 5.997 mg/L 3compartmentss NA 95% Human Human -DTXSID2046543 Css NA 0.8582 mg/L PBTK NA 50% Human Human -DTXSID2046543 Css NA 3.792 mg/L PBTK NA 95% Human Human -DTXSID2046543 Clint NA 0.1217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046543 Fup NA 0.5194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046543 Vd NA 0.5705 L/kg 1compartment NA NA Rat Human +DTXSID2046543 TK.Half.Life NA 0.5424 hours 1compartment NA NA Human Human +DTXSID2046543 Css NA 0.0331 mg/L 3compartmentss NA 50% Human Human +DTXSID2046543 Css NA 0.3327 mg/L 3compartmentss NA 95% Human Human +DTXSID2046543 Css NA 0.02525 mg/L PBTK NA 50% Human Human +DTXSID2046543 Css NA 0.2195 mg/L PBTK NA 95% Human Human +DTXSID2046543 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046543 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046543 Vd NA 0.599 L/kg 1compartment NA NA Rat Human DTXSID2046543 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046543 TK.Half.Life NA 2.185 hours 1compartment NA NA Rat Human -DTXSID2046543 Css NA 0.3426 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046543 Css NA 1.741 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046543 Css NA 0.2497 mg/L PBTK NA 50% Rat Human -DTXSID2046543 Css NA 1.022 mg/L PBTK NA 95% Rat Human +DTXSID2046543 TK.Half.Life NA 0.2785 hours 1compartment NA NA Rat Human +DTXSID2046543 Css NA 0.004049 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046543 Css NA 0.03572 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046543 Css NA 0.003131 mg/L PBTK NA 50% Rat Human +DTXSID2046543 Css NA 0.02327 mg/L PBTK NA 95% Rat Human +DTXSID2046545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046545 Fup 0.0315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046545 Vd NA 1.283 L/kg 1compartment NA NA Human Human +DTXSID2046545 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046545 TK.Half.Life NA 8.188 hours 1compartment NA NA Human Human +DTXSID2046545 Css NA 0.9525 mg/L 3compartmentss NA 50% Human Human +DTXSID2046545 Css NA 8.676 mg/L 3compartmentss NA 95% Human Human +DTXSID2046545 Css NA 0.5972 mg/L PBTK NA 50% Human Human +DTXSID2046545 Css NA 5.241 mg/L PBTK NA 95% Human Human +DTXSID2046545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046545 Fup 0.0315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046545 Vd NA 0.959 L/kg 1compartment NA NA Rat Human +DTXSID2046545 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2046545 TK.Half.Life NA 3.352 hours 1compartment NA NA Rat Human +DTXSID2046545 Css NA 0.1248 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046545 Css NA 0.8978 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046545 Css NA 0.07576 mg/L PBTK NA 50% Rat Human +DTXSID2046545 Css NA 0.5206 mg/L PBTK NA 95% Rat Human DTXSID2046549 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2046549 Fup NA 0.5848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046549 Vd NA 1.758 L/kg 1compartment NA NA Human Human -DTXSID2046549 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2046549 TK.Half.Life NA 19.72 hours 1compartment NA NA Human Human -DTXSID2046549 Css NA 1.094 mg/L 3compartmentss NA 50% Human Human -DTXSID2046549 Css NA 8.424 mg/L 3compartmentss NA 95% Human Human -DTXSID2046549 Css NA 1.014 mg/L PBTK NA 50% Human Human -DTXSID2046549 Css NA 5.439 mg/L PBTK NA 95% Human Human +DTXSID2046549 Vd NA 0.5046 L/kg 1compartment NA NA Human Human +DTXSID2046549 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046549 TK.Half.Life NA 5.59 hours 1compartment NA NA Human Human +DTXSID2046549 Css NA 1.164 mg/L 3compartmentss NA 50% Human Human +DTXSID2046549 Css NA 7.714 mg/L 3compartmentss NA 95% Human Human +DTXSID2046549 Css NA 0.8601 mg/L PBTK NA 50% Human Human +DTXSID2046549 Css NA 4.738 mg/L PBTK NA 95% Human Human DTXSID2046549 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2046549 Fup NA 0.5848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046549 Vd NA 1.773 L/kg 1compartment NA NA Rat Human +DTXSID2046549 Vd NA 0.5157 L/kg 1compartment NA NA Rat Human DTXSID2046549 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046549 TK.Half.Life NA 6.704 hours 1compartment NA NA Rat Human -DTXSID2046549 Css NA 0.2816 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046549 Css NA 2.102 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046549 Css NA 0.2547 mg/L PBTK NA 50% Rat Human -DTXSID2046549 Css NA 1.287 mg/L PBTK NA 95% Rat Human -DTXSID2046591 Clint NA 32.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046591 Fup NA 0.2683 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046591 Vd NA 3.132 L/kg 1compartment NA NA Human Human -DTXSID2046591 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2046591 TK.Half.Life NA 39.77 hours 1compartment NA NA Human Human -DTXSID2046591 Css NA 1.469 mg/L 3compartmentss NA 50% Human Human -DTXSID2046591 Css NA 9.48 mg/L 3compartmentss NA 95% Human Human -DTXSID2046591 Css NA 1.023 mg/L PBTK NA 50% Human Human -DTXSID2046591 Css NA 6.395 mg/L PBTK NA 95% Human Human -DTXSID2046591 Clint NA 32.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046591 Fup NA 0.2683 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046591 Vd NA 2.349 L/kg 1compartment NA NA Rat Human -DTXSID2046591 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2046591 TK.Half.Life NA 5.576 hours 1compartment NA NA Rat Human -DTXSID2046591 Css NA 0.8219 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046591 Css NA 4.23 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046591 Css NA 0.551 mg/L PBTK NA 50% Rat Human -DTXSID2046591 Css NA 2.785 mg/L PBTK NA 95% Rat Human +DTXSID2046549 TK.Half.Life NA 1.945 hours 1compartment NA NA Rat Human +DTXSID2046549 Css NA 0.02213 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046549 Css NA 0.1838 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046549 Css NA 0.01572 mg/L PBTK NA 50% Rat Human +DTXSID2046549 Css NA 0.1119 mg/L PBTK NA 95% Rat Human +DTXSID2046591 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046591 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046591 Vd NA 0.4278 L/kg 1compartment NA NA Human Human +DTXSID2046591 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046591 TK.Half.Life NA 1.481 hours 1compartment NA NA Human Human +DTXSID2046591 Css NA 0.3472 mg/L 3compartmentss NA 50% Human Human +DTXSID2046591 Css NA 2.002 mg/L 3compartmentss NA 95% Human Human +DTXSID2046591 Css NA 0.2297 mg/L PBTK NA 50% Human Human +DTXSID2046591 Css NA 1.265 mg/L PBTK NA 95% Human Human +DTXSID2046591 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046591 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046591 Vd NA 0.4201 L/kg 1compartment NA NA Rat Human +DTXSID2046591 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2046591 TK.Half.Life NA 0.8516 hours 1compartment NA NA Rat Human +DTXSID2046591 Css NA 0.04098 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046591 Css NA 0.178 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046591 Css NA 0.02685 mg/L PBTK NA 50% Rat Human +DTXSID2046591 Css NA 0.1081 mg/L PBTK NA 95% Rat Human DTXSID2046593 Clint NA 513.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2046593 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046593 Vd NA 2250 L/kg 1compartment NA NA Human Human -DTXSID2046593 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID2046593 TK.Half.Life NA 2825 hours 1compartment NA NA Human Human -DTXSID2046593 Css NA 0.0002692 mg/L 3compartmentss NA 50% Human Human -DTXSID2046593 Css NA 0.001704 mg/L 3compartmentss NA 95% Human Human -DTXSID2046593 Css NA 0.1038 mg/L PBTK NA 50% Human Human -DTXSID2046593 Css NA 0.5801 mg/L PBTK NA 95% Human Human +DTXSID2046593 Vd NA 322.3 L/kg 1compartment NA NA Human Human +DTXSID2046593 Days.Css NA 85 Days PBTK NA NA Human Human +DTXSID2046593 TK.Half.Life NA 407.7 hours 1compartment NA NA Human Human +DTXSID2046593 Css NA 0.001063 mg/L 3compartmentss NA 50% Human Human +DTXSID2046593 Css NA 0.008254 mg/L 3compartmentss NA 95% Human Human +DTXSID2046593 Css NA 0.04906 mg/L PBTK NA 50% Human Human +DTXSID2046593 Css NA 0.352 mg/L PBTK NA 95% Human Human DTXSID2046593 Clint NA 513.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2046593 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046593 Vd NA 2086 L/kg 1compartment NA NA Rat Human -DTXSID2046593 Days.Css NA 498 Days PBTK NA NA Rat Human -DTXSID2046593 TK.Half.Life NA 462.7 hours 1compartment NA NA Rat Human -DTXSID2046593 Css NA 0.0001374 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046593 Css NA 0.0006004 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046593 Css NA 0.05643 mg/L PBTK NA 50% Rat Human -DTXSID2046593 Css NA 0.2433 mg/L PBTK NA 95% Rat Human +DTXSID2046593 Vd NA 288.4 L/kg 1compartment NA NA Rat Human +DTXSID2046593 Days.Css NA 61 Days PBTK NA NA Rat Human +DTXSID2046593 TK.Half.Life NA 65.27 hours 1compartment NA NA Rat Human +DTXSID2046593 Css NA 9.735e-06 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046593 Css NA 6.969e-05 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046593 Css NA 0.0004782 mg/L PBTK NA 50% Rat Human +DTXSID2046593 Css NA 0.003321 mg/L PBTK NA 95% Rat Human DTXSID2046597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2046597 Fup NA 0.5459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046597 Vd NA 1.76 L/kg 1compartment NA NA Human Human -DTXSID2046597 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2046597 TK.Half.Life NA 21.5 hours 1compartment NA NA Human Human -DTXSID2046597 Css NA 1.165 mg/L 3compartmentss NA 50% Human Human -DTXSID2046597 Css NA 8.135 mg/L 3compartmentss NA 95% Human Human -DTXSID2046597 Css NA 1.074 mg/L PBTK NA 50% Human Human -DTXSID2046597 Css NA 5.391 mg/L PBTK NA 95% Human Human +DTXSID2046597 Vd NA 0.3739 L/kg 1compartment NA NA Human Human +DTXSID2046597 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046597 TK.Half.Life NA 4.432 hours 1compartment NA NA Human Human +DTXSID2046597 Css NA 1.266 mg/L 3compartmentss NA 50% Human Human +DTXSID2046597 Css NA 7.639 mg/L 3compartmentss NA 95% Human Human +DTXSID2046597 Css NA 0.8844 mg/L PBTK NA 50% Human Human +DTXSID2046597 Css NA 4.693 mg/L PBTK NA 95% Human Human DTXSID2046597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2046597 Fup NA 0.5459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046597 Vd NA 1.75 L/kg 1compartment NA NA Rat Human +DTXSID2046597 Vd NA 0.3941 L/kg 1compartment NA NA Rat Human DTXSID2046597 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046597 TK.Half.Life NA 7.119 hours 1compartment NA NA Rat Human -DTXSID2046597 Css NA 0.3098 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046597 Css NA 1.961 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046597 Css NA 0.2766 mg/L PBTK NA 50% Rat Human -DTXSID2046597 Css NA 1.216 mg/L PBTK NA 95% Rat Human -DTXSID2046599 Clint NA 7.754 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046599 Fup NA 0.2101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046599 Vd NA 0.4791 L/kg 1compartment NA NA Human Human +DTXSID2046597 TK.Half.Life NA 1.592 hours 1compartment NA NA Rat Human +DTXSID2046597 Css NA 0.0244 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046597 Css NA 0.1875 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046597 Css NA 0.01643 mg/L PBTK NA 50% Rat Human +DTXSID2046597 Css NA 0.1135 mg/L PBTK NA 95% Rat Human +DTXSID2046599 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046599 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046599 Vd NA 0.59 L/kg 1compartment NA NA Human Human DTXSID2046599 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046599 TK.Half.Life NA 1.408 hours 1compartment NA NA Human Human -DTXSID2046599 Css NA 0.2879 mg/L 3compartmentss NA 50% Human Human -DTXSID2046599 Css NA 1.723 mg/L 3compartmentss NA 95% Human Human -DTXSID2046599 Css NA 0.193 mg/L PBTK NA 50% Human Human -DTXSID2046599 Css NA 1.074 mg/L PBTK NA 95% Human Human -DTXSID2046599 Clint NA 7.754 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046599 Fup NA 0.2101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046599 Vd NA 0.4524 L/kg 1compartment NA NA Rat Human +DTXSID2046599 TK.Half.Life NA 1.174 hours 1compartment NA NA Human Human +DTXSID2046599 Css NA 0.1562 mg/L 3compartmentss NA 50% Human Human +DTXSID2046599 Css NA 1.078 mg/L 3compartmentss NA 95% Human Human +DTXSID2046599 Css NA 0.1179 mg/L PBTK NA 50% Human Human +DTXSID2046599 Css NA 0.7309 mg/L PBTK NA 95% Human Human +DTXSID2046599 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046599 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046599 Vd NA 0.5994 L/kg 1compartment NA NA Rat Human DTXSID2046599 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046599 TK.Half.Life NA 0.7741 hours 1compartment NA NA Rat Human -DTXSID2046599 Css NA 0.1525 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046599 Css NA 0.6566 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046599 Css NA 0.09654 mg/L PBTK NA 50% Rat Human -DTXSID2046599 Css NA 0.3918 mg/L PBTK NA 95% Rat Human +DTXSID2046599 TK.Half.Life NA 0.6684 hours 1compartment NA NA Rat Human +DTXSID2046599 Css NA 0.01806 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046599 Css NA 0.09053 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046599 Css NA 0.01362 mg/L PBTK NA 50% Rat Human +DTXSID2046599 Css NA 0.05908 mg/L PBTK NA 95% Rat Human DTXSID2046624 Clint 2160 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.105.0042595 NA Human Human DTXSID2046624 Fup 0.013 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID2046624 Vd NA 0.4065 L/kg 1compartment NA NA Human Human +DTXSID2046624 Vd NA 0.9991 L/kg 1compartment NA NA Human Human DTXSID2046624 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046624 TK.Half.Life NA 0.3821 hours 1compartment NA NA Human Human -DTXSID2046624 Css NA 0.02146 mg/L 3compartmentss NA 50% Human Human -DTXSID2046624 Css NA 0.2358 mg/L 3compartmentss NA 95% Human Human -DTXSID2046624 Css NA 0.01453 mg/L PBTK NA 50% Human Human -DTXSID2046624 Css NA 0.1491 mg/L PBTK NA 95% Human Human +DTXSID2046624 TK.Half.Life NA 0.93 hours 1compartment NA NA Human Human +DTXSID2046624 Css NA 0.01679 mg/L 3compartmentss NA 50% Human Human +DTXSID2046624 Css NA 0.1928 mg/L 3compartmentss NA 95% Human Human +DTXSID2046624 Css NA 0.01149 mg/L PBTK NA 50% Human Human +DTXSID2046624 Css NA 0.1319 mg/L PBTK NA 95% Human Human DTXSID2046624 Clint 2160 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.105.0042595 NA Rat Human DTXSID2046624 Fup 0.013 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human -DTXSID2046624 Vd NA 0.3262 L/kg 1compartment NA NA Rat Human +DTXSID2046624 Vd 5.1 0.7402 L/kg 1compartment Wambaugh et al. (2018) NA Rat Human DTXSID2046624 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046624 TK.Half.Life NA 0.1449 hours 1compartment NA NA Rat Human -DTXSID2046624 Css NA 0.01238 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046624 Css NA 0.1205 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046624 Css NA 0.007892 mg/L PBTK NA 50% Rat Human -DTXSID2046624 Css NA 0.06947 mg/L PBTK NA 95% Rat Human -DTXSID2046626 Clint NA 15.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046626 Fup NA 0.118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046626 Vd NA 2.814 L/kg 1compartment NA NA Human Human -DTXSID2046626 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2046626 TK.Half.Life NA 21.78 hours 1compartment NA NA Human Human -DTXSID2046626 Css NA 0.9235 mg/L 3compartmentss NA 50% Human Human -DTXSID2046626 Css NA 5.571 mg/L 3compartmentss NA 95% Human Human -DTXSID2046626 Css NA 0.6433 mg/L PBTK NA 50% Human Human -DTXSID2046626 Css NA 3.714 mg/L PBTK NA 95% Human Human -DTXSID2046626 Clint NA 15.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046626 Fup NA 0.118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046626 Vd NA 2.119 L/kg 1compartment NA NA Rat Human -DTXSID2046626 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2046626 TK.Half.Life NA 4.438 hours 1compartment NA NA Rat Human -DTXSID2046626 Css NA 0.5066 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046626 Css NA 2.405 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046626 Css NA 0.3379 mg/L PBTK NA 50% Rat Human -DTXSID2046626 Css NA 1.526 mg/L PBTK NA 95% Rat Human -DTXSID2046628 Clint NA 60.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046628 Fup NA 0.1777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046628 Vd NA 1.922 L/kg 1compartment NA NA Human Human +DTXSID2046624 TK.Half.Life 0.25 0.318 hours 1compartment Wambaugh et al. (2018) NA Rat Human +DTXSID2046624 Css 0.003 0.002162 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Human +DTXSID2046624 Css 0.003 0.01978 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Human +DTXSID2046624 Css 0.003 0.001538 mg/L PBTK Wambaugh et al. (2018) 50% Rat Human +DTXSID2046624 Css 0.003 0.01403 mg/L PBTK Wambaugh et al. (2018) 95% Rat Human +DTXSID2046626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046626 Fup 0.0895 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046626 Vd NA 2.174 L/kg 1compartment NA NA Human Human +DTXSID2046626 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046626 TK.Half.Life NA 8.428 hours 1compartment NA NA Human Human +DTXSID2046626 Css NA 0.4356 mg/L 3compartmentss NA 50% Human Human +DTXSID2046626 Css NA 3.034 mg/L 3compartmentss NA 95% Human Human +DTXSID2046626 Css NA 0.2958 mg/L PBTK NA 50% Human Human +DTXSID2046626 Css NA 1.929 mg/L PBTK NA 95% Human Human +DTXSID2046626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046626 Fup 0.0895 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046626 Vd NA 1.64 L/kg 1compartment NA NA Rat Human +DTXSID2046626 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2046626 TK.Half.Life NA 2.599 hours 1compartment NA NA Rat Human +DTXSID2046626 Css NA 0.05654 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046626 Css NA 0.3116 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046626 Css NA 0.03761 mg/L PBTK NA 50% Rat Human +DTXSID2046626 Css NA 0.1984 mg/L PBTK NA 95% Rat Human +DTXSID2046628 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046628 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046628 Vd NA 1.625 L/kg 1compartment NA NA Human Human DTXSID2046628 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046628 TK.Half.Life NA 1.964 hours 1compartment NA NA Human Human -DTXSID2046628 Css NA 0.03998 mg/L 3compartmentss NA 50% Human Human -DTXSID2046628 Css NA 0.3244 mg/L 3compartmentss NA 95% Human Human -DTXSID2046628 Css NA 0.03243 mg/L PBTK NA 50% Human Human -DTXSID2046628 Css NA 0.2361 mg/L PBTK NA 95% Human Human -DTXSID2046628 Clint NA 60.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046628 Fup NA 0.1777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046628 Vd NA 1.816 L/kg 1compartment NA NA Rat Human +DTXSID2046628 TK.Half.Life NA 6.684 hours 1compartment NA NA Human Human +DTXSID2046628 Css NA 0.4241 mg/L 3compartmentss NA 50% Human Human +DTXSID2046628 Css NA 2.897 mg/L 3compartmentss NA 95% Human Human +DTXSID2046628 Css NA 0.3244 mg/L PBTK NA 50% Human Human +DTXSID2046628 Css NA 1.984 mg/L PBTK NA 95% Human Human +DTXSID2046628 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046628 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046628 Vd NA 1.55 L/kg 1compartment NA NA Rat Human DTXSID2046628 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046628 TK.Half.Life NA 0.9352 hours 1compartment NA NA Rat Human -DTXSID2046628 Css NA 0.02223 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046628 Css NA 0.1333 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046628 Css NA 0.0173 mg/L PBTK NA 50% Rat Human -DTXSID2046628 Css NA 0.09323 mg/L PBTK NA 95% Rat Human -DTXSID2046670 Clint NA 54.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046670 Fup NA 0.3195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046670 Vd NA 3.807 L/kg 1compartment NA NA Human Human +DTXSID2046628 TK.Half.Life NA 3.709 hours 1compartment NA NA Rat Human +DTXSID2046628 Css NA 0.05056 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046628 Css NA 0.2614 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046628 Css NA 0.03876 mg/L PBTK NA 50% Rat Human +DTXSID2046628 Css NA 0.1715 mg/L PBTK NA 95% Rat Human +DTXSID2046670 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046670 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046670 Vd NA 4.25 L/kg 1compartment NA NA Human Human DTXSID2046670 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046670 TK.Half.Life NA 2.777 hours 1compartment NA NA Human Human -DTXSID2046670 Css NA 0.02073 mg/L 3compartmentss NA 50% Human Human -DTXSID2046670 Css NA 0.1618 mg/L 3compartmentss NA 95% Human Human -DTXSID2046670 Css NA 0.02266 mg/L PBTK NA 50% Human Human -DTXSID2046670 Css NA 0.1468 mg/L PBTK NA 95% Human Human -DTXSID2046670 Clint NA 54.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046670 Fup NA 0.3195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046670 Vd NA 3.633 L/kg 1compartment NA NA Rat Human +DTXSID2046670 TK.Half.Life NA 9.639 hours 1compartment NA NA Human Human +DTXSID2046670 Css NA 0.1405 mg/L 3compartmentss NA 50% Human Human +DTXSID2046670 Css NA 0.9494 mg/L 3compartmentss NA 95% Human Human +DTXSID2046670 Css NA 0.1627 mg/L PBTK NA 50% Human Human +DTXSID2046670 Css NA 0.9061 mg/L PBTK NA 95% Human Human +DTXSID2046670 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046670 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046670 Vd NA 4.04 L/kg 1compartment NA NA Rat Human DTXSID2046670 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046670 TK.Half.Life NA 1.232 hours 1compartment NA NA Rat Human -DTXSID2046670 Css NA 0.01097 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046670 Css NA 0.07379 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046670 Css NA 0.01198 mg/L PBTK NA 50% Rat Human -DTXSID2046670 Css NA 0.06755 mg/L PBTK NA 95% Rat Human -DTXSID2046674 Clint NA 137.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046674 Fup NA 0.0398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046674 Vd NA 0.6374 L/kg 1compartment NA NA Human Human -DTXSID2046674 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046674 TK.Half.Life NA 1.023 hours 1compartment NA NA Human Human -DTXSID2046674 Css NA 0.1269 mg/L 3compartmentss NA 50% Human Human -DTXSID2046674 Css NA 1.258 mg/L 3compartmentss NA 95% Human Human -DTXSID2046674 Css NA 0.07749 mg/L PBTK NA 50% Human Human -DTXSID2046674 Css NA 0.7579 mg/L PBTK NA 95% Human Human -DTXSID2046674 Clint NA 137.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046674 Fup NA 0.0398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046674 Vd NA 0.4945 L/kg 1compartment NA NA Rat Human -DTXSID2046674 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046674 TK.Half.Life NA 0.4229 hours 1compartment NA NA Rat Human -DTXSID2046674 Css NA 0.07387 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046674 Css NA 0.6037 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046674 Css NA 0.04184 mg/L PBTK NA 50% Rat Human -DTXSID2046674 Css NA 0.3365 mg/L PBTK NA 95% Rat Human -DTXSID2046678 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2046670 TK.Half.Life NA 4.106 hours 1compartment NA NA Rat Human +DTXSID2046670 Css NA 0.01589 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046670 Css NA 0.08408 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046670 Css NA 0.01933 mg/L PBTK NA 50% Rat Human +DTXSID2046670 Css NA 0.0763 mg/L PBTK NA 95% Rat Human +DTXSID2046674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046674 Fup 0.0367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046674 Vd NA 2.598 L/kg 1compartment NA NA Human Human +DTXSID2046674 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2046674 TK.Half.Life NA 24.4 hours 1compartment NA NA Human Human +DTXSID2046674 Css NA 1.223 mg/L 3compartmentss NA 50% Human Human +DTXSID2046674 Css NA 8.136 mg/L 3compartmentss NA 95% Human Human +DTXSID2046674 Css NA 0.8218 mg/L PBTK NA 50% Human Human +DTXSID2046674 Css NA 5.289 mg/L PBTK NA 95% Human Human +DTXSID2046674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046674 Fup 0.0367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046674 Vd NA 1.941 L/kg 1compartment NA NA Rat Human +DTXSID2046674 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2046674 TK.Half.Life NA 5.691 hours 1compartment NA NA Rat Human +DTXSID2046674 Css NA 0.1576 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046674 Css NA 0.8792 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046674 Css NA 0.1041 mg/L PBTK NA 50% Rat Human +DTXSID2046674 Css NA 0.5632 mg/L PBTK NA 95% Rat Human +DTXSID2046678 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2046678 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2046678 Vd NA 0.7133 L/kg 1compartment NA NA Human Human +DTXSID2046678 Vd NA 0.6121 L/kg 1compartment NA NA Human Human DTXSID2046678 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046678 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human -DTXSID2046678 Css NA 0.9294 mg/L 3compartmentss NA 50% Human Human -DTXSID2046678 Css NA 5.23 mg/L 3compartmentss NA 95% Human Human -DTXSID2046678 Css NA 0.7565 mg/L PBTK NA 50% Human Human -DTXSID2046678 Css NA 3.422 mg/L PBTK NA 95% Human Human -DTXSID2046678 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2046678 TK.Half.Life NA 4.305 hours 1compartment NA NA Human Human +DTXSID2046678 Css NA 0.5212 mg/L 3compartmentss NA 50% Human Human +DTXSID2046678 Css NA 2.94 mg/L 3compartmentss NA 95% Human Human +DTXSID2046678 Css NA 0.4174 mg/L PBTK NA 50% Human Human +DTXSID2046678 Css NA 1.94 mg/L PBTK NA 95% Human Human +DTXSID2046678 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2046678 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2046678 Vd NA 0.7436 L/kg 1compartment NA NA Rat Human +DTXSID2046678 Vd NA 0.6379 L/kg 1compartment NA NA Rat Human DTXSID2046678 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046678 TK.Half.Life NA 1.782 hours 1compartment NA NA Rat Human -DTXSID2046678 Css NA 0.2393 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046678 Css NA 1.286 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046678 Css NA 0.1888 mg/L PBTK NA 50% Rat Human -DTXSID2046678 Css NA 0.7724 mg/L PBTK NA 95% Rat Human -DTXSID2046701 Clint NA 153 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046701 Fup NA 0.1289 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046701 Vd NA 3.847 L/kg 1compartment NA NA Human Human +DTXSID2046678 TK.Half.Life NA 1.529 hours 1compartment NA NA Rat Human +DTXSID2046678 Css NA 0.002668 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046678 Css NA 0.01617 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046678 Css NA 0.002064 mg/L PBTK NA 50% Rat Human +DTXSID2046678 Css NA 0.01026 mg/L PBTK NA 95% Rat Human +DTXSID2046701 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046701 Fup 0.0619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046701 Vd NA 3.434 L/kg 1compartment NA NA Human Human DTXSID2046701 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046701 TK.Half.Life NA 2.516 hours 1compartment NA NA Human Human -DTXSID2046701 Css NA 0.01266 mg/L 3compartmentss NA 50% Human Human -DTXSID2046701 Css NA 0.1099 mg/L 3compartmentss NA 95% Human Human -DTXSID2046701 Css NA 0.01243 mg/L PBTK NA 50% Human Human -DTXSID2046701 Css NA 0.09041 mg/L PBTK NA 95% Human Human -DTXSID2046701 Clint NA 153 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046701 Fup NA 0.1289 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046701 Vd NA 3.59 L/kg 1compartment NA NA Rat Human +DTXSID2046701 TK.Half.Life NA 6.245 hours 1compartment NA NA Human Human +DTXSID2046701 Css NA 0.1332 mg/L 3compartmentss NA 50% Human Human +DTXSID2046701 Css NA 1.003 mg/L 3compartmentss NA 95% Human Human +DTXSID2046701 Css NA 0.1067 mg/L PBTK NA 50% Human Human +DTXSID2046701 Css NA 0.7527 mg/L PBTK NA 95% Human Human +DTXSID2046701 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046701 Fup 0.0619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046701 Vd NA 2.882 L/kg 1compartment NA NA Rat Human DTXSID2046701 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046701 TK.Half.Life NA 1.045 hours 1compartment NA NA Rat Human -DTXSID2046701 Css NA 0.006968 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046701 Css NA 0.04847 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046701 Css NA 0.006667 mg/L PBTK NA 50% Rat Human -DTXSID2046701 Css NA 0.03968 mg/L PBTK NA 95% Rat Human +DTXSID2046701 TK.Half.Life NA 1.897 hours 1compartment NA NA Rat Human +DTXSID2046701 Css NA 0.01722 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046701 Css NA 0.1105 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046701 Css NA 0.01396 mg/L PBTK NA 50% Rat Human +DTXSID2046701 Css NA 0.08324 mg/L PBTK NA 95% Rat Human DTXSID2046703 Clint NA 155.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2046703 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046703 Vd NA 750.9 L/kg 1compartment NA NA Human Human -DTXSID2046703 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID2046703 TK.Half.Life NA 2565 hours 1compartment NA NA Human Human -DTXSID2046703 Css NA 0.00324 mg/L 3compartmentss NA 50% Human Human -DTXSID2046703 Css NA 0.03754 mg/L 3compartmentss NA 95% Human Human -DTXSID2046703 Css NA 0.3342 mg/L PBTK NA 50% Human Human -DTXSID2046703 Css NA 2.163 mg/L PBTK NA 95% Human Human +DTXSID2046703 Vd NA 0.4411 L/kg 1compartment NA NA Human Human +DTXSID2046703 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046703 TK.Half.Life NA 2.417 hours 1compartment NA NA Human Human +DTXSID2046703 Css NA 0.8452 mg/L 3compartmentss NA 50% Human Human +DTXSID2046703 Css NA 8.624 mg/L 3compartmentss NA 95% Human Human +DTXSID2046703 Css NA 0.4982 mg/L PBTK NA 50% Human Human +DTXSID2046703 Css NA 4.991 mg/L PBTK NA 95% Human Human DTXSID2046703 Clint NA 155.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2046703 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046703 Vd NA 684 L/kg 1compartment NA NA Rat Human -DTXSID2046703 Days.Css NA 445 Days PBTK NA NA Rat Human -DTXSID2046703 TK.Half.Life NA 660.8 hours 1compartment NA NA Rat Human -DTXSID2046703 Css NA 0.001557 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046703 Css NA 0.01605 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046703 Css NA 0.1786 mg/L PBTK NA 50% Rat Human -DTXSID2046703 Css NA 0.9969 mg/L PBTK NA 95% Rat Human -DTXSID2046705 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046705 Fup NA 0.037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046705 Vd NA 0.6823 L/kg 1compartment NA NA Human Human -DTXSID2046705 Days.Css NA 27 Days PBTK NA NA Human Human -DTXSID2046705 TK.Half.Life NA 122.9 hours 1compartment NA NA Human Human -DTXSID2046705 Css NA 27.77 mg/L 3compartmentss NA 50% Human Human -DTXSID2046705 Css NA 163.8 mg/L 3compartmentss NA 95% Human Human -DTXSID2046705 Css NA 18.53 mg/L PBTK NA 50% Human Human -DTXSID2046705 Css NA 98.14 mg/L PBTK NA 95% Human Human -DTXSID2046705 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046705 Fup NA 0.037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046705 Vd NA 0.6159 L/kg 1compartment NA NA Rat Human -DTXSID2046705 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID2046705 TK.Half.Life NA 36.97 hours 1compartment NA NA Rat Human -DTXSID2046705 Css NA 7.902 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046705 Css NA 38.03 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046705 Css NA 4.958 mg/L PBTK NA 50% Rat Human -DTXSID2046705 Css NA 21.31 mg/L PBTK NA 95% Rat Human -DTXSID2046707 Clint NA 65.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046707 Fup NA 0.0213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046707 Vd NA 0.3817 L/kg 1compartment NA NA Human Human +DTXSID2046703 Vd NA 0.3366 L/kg 1compartment NA NA Rat Human +DTXSID2046703 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2046703 TK.Half.Life NA 1.18 hours 1compartment NA NA Rat Human +DTXSID2046703 Css NA 0.114 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046703 Css NA 0.9647 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046703 Css NA 0.0646 mg/L PBTK NA 50% Rat Human +DTXSID2046703 Css NA 0.5411 mg/L PBTK NA 95% Rat Human +DTXSID2046705 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046705 Fup 0.0521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046705 Vd NA 0.7099 L/kg 1compartment NA NA Human Human +DTXSID2046705 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID2046705 TK.Half.Life NA 90.37 hours 1compartment NA NA Human Human +DTXSID2046705 Css NA 9.78 mg/L 3compartmentss NA 50% Human Human +DTXSID2046705 Css NA 54.69 mg/L 3compartmentss NA 95% Human Human +DTXSID2046705 Css NA 6.812 mg/L PBTK NA 50% Human Human +DTXSID2046705 Css NA 33.62 mg/L PBTK NA 95% Human Human +DTXSID2046705 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046705 Fup 0.0521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046705 Vd NA 0.6555 L/kg 1compartment NA NA Rat Human +DTXSID2046705 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID2046705 TK.Half.Life NA 27.9 hours 1compartment NA NA Rat Human +DTXSID2046705 Css NA 0.05374 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046705 Css NA 0.3008 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046705 Css NA 0.03521 mg/L PBTK NA 50% Rat Human +DTXSID2046705 Css NA 0.1747 mg/L PBTK NA 95% Rat Human +DTXSID2046707 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046707 Fup 0.0734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046707 Vd NA 1.074 L/kg 1compartment NA NA Human Human DTXSID2046707 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046707 TK.Half.Life NA 1.355 hours 1compartment NA NA Human Human -DTXSID2046707 Css NA 0.4942 mg/L 3compartmentss NA 50% Human Human -DTXSID2046707 Css NA 5.038 mg/L 3compartmentss NA 95% Human Human -DTXSID2046707 Css NA 0.2955 mg/L PBTK NA 50% Human Human -DTXSID2046707 Css NA 2.977 mg/L PBTK NA 95% Human Human -DTXSID2046707 Clint NA 65.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046707 Fup NA 0.0213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046707 Vd NA 0.318 L/kg 1compartment NA NA Rat Human +DTXSID2046707 TK.Half.Life NA 3.488 hours 1compartment NA NA Human Human +DTXSID2046707 Css NA 0.3358 mg/L 3compartmentss NA 50% Human Human +DTXSID2046707 Css NA 2.691 mg/L 3compartmentss NA 95% Human Human +DTXSID2046707 Css NA 0.2258 mg/L PBTK NA 50% Human Human +DTXSID2046707 Css NA 1.697 mg/L PBTK NA 95% Human Human +DTXSID2046707 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046707 Fup 0.0734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046707 Vd NA 0.8444 L/kg 1compartment NA NA Rat Human DTXSID2046707 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046707 TK.Half.Life NA 0.6987 hours 1compartment NA NA Rat Human -DTXSID2046707 Css NA 0.2872 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046707 Css NA 2.272 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046707 Css NA 0.1613 mg/L PBTK NA 50% Rat Human -DTXSID2046707 Css NA 1.249 mg/L PBTK NA 95% Rat Human -DTXSID2046709 Clint NA 45.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046709 Fup NA 0.2218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046709 Vd NA 3.349 L/kg 1compartment NA NA Human Human +DTXSID2046707 TK.Half.Life NA 1.539 hours 1compartment NA NA Rat Human +DTXSID2046707 Css NA 0.01631 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046707 Css NA 0.1392 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046707 Css NA 0.01056 mg/L PBTK NA 50% Rat Human +DTXSID2046707 Css NA 0.08435 mg/L PBTK NA 95% Rat Human +DTXSID2046709 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046709 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046709 Vd NA 2.773 L/kg 1compartment NA NA Human Human DTXSID2046709 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046709 TK.Half.Life NA 2.794 hours 1compartment NA NA Human Human -DTXSID2046709 Css NA 0.02895 mg/L 3compartmentss NA 50% Human Human -DTXSID2046709 Css NA 0.228 mg/L 3compartmentss NA 95% Human Human -DTXSID2046709 Css NA 0.03043 mg/L PBTK NA 50% Human Human -DTXSID2046709 Css NA 0.1968 mg/L PBTK NA 95% Human Human -DTXSID2046709 Clint NA 45.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046709 Fup NA 0.2218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046709 Vd NA 3.31 L/kg 1compartment NA NA Rat Human +DTXSID2046709 TK.Half.Life NA 5.161 hours 1compartment NA NA Human Human +DTXSID2046709 Css NA 0.1158 mg/L 3compartmentss NA 50% Human Human +DTXSID2046709 Css NA 0.8832 mg/L 3compartmentss NA 95% Human Human +DTXSID2046709 Css NA 0.1223 mg/L PBTK NA 50% Human Human +DTXSID2046709 Css NA 0.7491 mg/L PBTK NA 95% Human Human +DTXSID2046709 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046709 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046709 Vd NA 2.808 L/kg 1compartment NA NA Rat Human DTXSID2046709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046709 TK.Half.Life NA 1.409 hours 1compartment NA NA Rat Human -DTXSID2046709 Css NA 0.01519 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046709 Css NA 0.1007 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046709 Css NA 0.01608 mg/L PBTK NA 50% Rat Human -DTXSID2046709 Css NA 0.08712 mg/L PBTK NA 95% Rat Human -DTXSID2046751 Clint NA 63.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046751 Fup NA 0.1317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046751 Vd NA 3.445 L/kg 1compartment NA NA Human Human -DTXSID2046751 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046751 TK.Half.Life NA 3.175 hours 1compartment NA NA Human Human -DTXSID2046751 Css NA 0.03922 mg/L 3compartmentss NA 50% Human Human -DTXSID2046751 Css NA 0.3329 mg/L 3compartmentss NA 95% Human Human -DTXSID2046751 Css NA 0.0368 mg/L PBTK NA 50% Human Human -DTXSID2046751 Css NA 0.2645 mg/L PBTK NA 95% Human Human -DTXSID2046751 Clint NA 63.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046751 Fup NA 0.1317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046751 Vd NA 3.21 L/kg 1compartment NA NA Rat Human -DTXSID2046751 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046751 TK.Half.Life NA 1.383 hours 1compartment NA NA Rat Human -DTXSID2046751 Css NA 0.02127 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046751 Css NA 0.1535 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046751 Css NA 0.01943 mg/L PBTK NA 50% Rat Human -DTXSID2046751 Css NA 0.1215 mg/L PBTK NA 95% Rat Human -DTXSID2046755 Clint NA 10.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046755 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046755 Vd NA 1.248 L/kg 1compartment NA NA Human Human +DTXSID2046709 TK.Half.Life NA 3.016 hours 1compartment NA NA Rat Human +DTXSID2046709 Css NA 0.01318 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046709 Css NA 0.07589 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046709 Css NA 0.01442 mg/L PBTK NA 50% Rat Human +DTXSID2046709 Css NA 0.06122 mg/L PBTK NA 95% Rat Human +DTXSID2046751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046751 Fup 0.0486 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046751 Vd NA 2.56 L/kg 1compartment NA NA Human Human +DTXSID2046751 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2046751 TK.Half.Life NA 19.43 hours 1compartment NA NA Human Human +DTXSID2046751 Css NA 0.8395 mg/L 3compartmentss NA 50% Human Human +DTXSID2046751 Css NA 6.09 mg/L 3compartmentss NA 95% Human Human +DTXSID2046751 Css NA 0.5668 mg/L PBTK NA 50% Human Human +DTXSID2046751 Css NA 3.875 mg/L PBTK NA 95% Human Human +DTXSID2046751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046751 Fup 0.0486 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046751 Vd NA 1.918 L/kg 1compartment NA NA Rat Human +DTXSID2046751 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2046751 TK.Half.Life NA 4.735 hours 1compartment NA NA Rat Human +DTXSID2046751 Css NA 0.04163 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046751 Css NA 0.3115 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046751 Css NA 0.02764 mg/L PBTK NA 50% Rat Human +DTXSID2046751 Css NA 0.191 mg/L PBTK NA 95% Rat Human +DTXSID2046755 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046755 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046755 Vd NA 1.119 L/kg 1compartment NA NA Human Human DTXSID2046755 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046755 TK.Half.Life NA 4.99 hours 1compartment NA NA Human Human -DTXSID2046755 Css NA 0.4953 mg/L 3compartmentss NA 50% Human Human -DTXSID2046755 Css NA 3.9 mg/L 3compartmentss NA 95% Human Human -DTXSID2046755 Css NA 0.348 mg/L PBTK NA 50% Human Human -DTXSID2046755 Css NA 2.505 mg/L PBTK NA 95% Human Human -DTXSID2046755 Clint NA 10.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046755 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046755 Vd NA 1.217 L/kg 1compartment NA NA Rat Human +DTXSID2046755 TK.Half.Life NA 1.81 hours 1compartment NA NA Human Human +DTXSID2046755 Css NA 0.0882 mg/L 3compartmentss NA 50% Human Human +DTXSID2046755 Css NA 0.6591 mg/L 3compartmentss NA 95% Human Human +DTXSID2046755 Css NA 0.0624 mg/L PBTK NA 50% Human Human +DTXSID2046755 Css NA 0.451 mg/L PBTK NA 95% Human Human +DTXSID2046755 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046755 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046755 Vd NA 0.9125 L/kg 1compartment NA NA Rat Human DTXSID2046755 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046755 TK.Half.Life NA 2.97 hours 1compartment NA NA Rat Human -DTXSID2046755 Css NA 0.266 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046755 Css NA 1.594 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046755 Css NA 0.177 mg/L PBTK NA 50% Rat Human -DTXSID2046755 Css NA 0.9405 mg/L PBTK NA 95% Rat Human +DTXSID2046755 TK.Half.Life NA 0.771 hours 1compartment NA NA Rat Human +DTXSID2046755 Css NA 0.004266 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046755 Css NA 0.03511 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046755 Css NA 0.003006 mg/L PBTK NA 50% Rat Human +DTXSID2046755 Css NA 0.02232 mg/L PBTK NA 95% Rat Human DTXSID2046759 Clint 27 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID2046759 Fup 0.21 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID2046759 Vd NA 0.4521 L/kg 1compartment NA NA Human Human DTXSID2046759 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2046759 TK.Half.Life NA 0.6496 hours 1compartment NA NA Human Human -DTXSID2046759 Css NA 0.08484 mg/L 3compartmentss NA 50% Human Human -DTXSID2046759 Css NA 0.5923 mg/L 3compartmentss NA 95% Human Human -DTXSID2046759 Css NA 0.05932 mg/L PBTK NA 50% Human Human -DTXSID2046759 Css NA 0.3825 mg/L PBTK NA 95% Human Human +DTXSID2046759 Css NA 0.07936 mg/L 3compartmentss NA 50% Human Human +DTXSID2046759 Css NA 0.5999 mg/L 3compartmentss NA 95% Human Human +DTXSID2046759 Css NA 0.05516 mg/L PBTK NA 50% Human Human +DTXSID2046759 Css NA 0.3918 mg/L PBTK NA 95% Human Human DTXSID2046759 Clint 28.54 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID2046759 Fup 0.21 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID2046759 Vd NA 0.4477 L/kg 1compartment NA NA Rat Rat DTXSID2046759 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID2046759 TK.Half.Life NA 0.3409 hours 1compartment NA NA Rat Rat -DTXSID2046759 Css NA 0.04446 mg/L 3compartmentss NA 50% Rat Rat -DTXSID2046759 Css NA 0.2418 mg/L 3compartmentss NA 95% Rat Rat -DTXSID2046759 Css NA 0.0295 mg/L PBTK NA 50% Rat Rat -DTXSID2046759 Css NA 0.151 mg/L PBTK NA 95% Rat Rat -DTXSID2046830 Clint NA 15.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046830 Fup NA 0.3502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046830 Vd NA 1.898 L/kg 1compartment NA NA Human Human -DTXSID2046830 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046830 TK.Half.Life NA 2.34 hours 1compartment NA NA Human Human -DTXSID2046830 Css NA 0.0658 mg/L 3compartmentss NA 50% Human Human -DTXSID2046830 Css NA 0.5273 mg/L 3compartmentss NA 95% Human Human -DTXSID2046830 Css NA 0.05992 mg/L PBTK NA 50% Human Human -DTXSID2046830 Css NA 0.4045 mg/L PBTK NA 95% Human Human -DTXSID2046830 Clint NA 15.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046830 Fup NA 0.3502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046830 Vd NA 1.889 L/kg 1compartment NA NA Rat Human -DTXSID2046830 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046830 TK.Half.Life NA 1.275 hours 1compartment NA NA Rat Human -DTXSID2046830 Css NA 0.03467 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046830 Css NA 0.2104 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046830 Css NA 0.03048 mg/L PBTK NA 50% Rat Human -DTXSID2046830 Css NA 0.1531 mg/L PBTK NA 95% Rat Human -DTXSID2046832 Clint NA 12.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046832 Fup NA 0.1278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046832 Vd NA 2.549 L/kg 1compartment NA NA Human Human +DTXSID2046759 Css NA 0.009652 mg/L 3compartmentss NA 50% Rat Rat +DTXSID2046759 Css NA 0.05518 mg/L 3compartmentss NA 95% Rat Rat +DTXSID2046759 Css NA 0.006675 mg/L PBTK NA 50% Rat Rat +DTXSID2046759 Css NA 0.03577 mg/L PBTK NA 95% Rat Rat +DTXSID2046832 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046832 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046832 Vd NA 1.031 L/kg 1compartment NA NA Human Human DTXSID2046832 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046832 TK.Half.Life NA 6.183 hours 1compartment NA NA Human Human -DTXSID2046832 Css NA 0.2218 mg/L 3compartmentss NA 50% Human Human -DTXSID2046832 Css NA 1.898 mg/L 3compartmentss NA 95% Human Human -DTXSID2046832 Css NA 0.1948 mg/L PBTK NA 50% Human Human -DTXSID2046832 Css NA 1.404 mg/L PBTK NA 95% Human Human -DTXSID2046832 Clint NA 12.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046832 Fup NA 0.1278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046832 Vd NA 2.521 L/kg 1compartment NA NA Rat Human +DTXSID2046832 TK.Half.Life NA 1.632 hours 1compartment NA NA Human Human +DTXSID2046832 Css NA 0.09898 mg/L 3compartmentss NA 50% Human Human +DTXSID2046832 Css NA 0.7213 mg/L 3compartmentss NA 95% Human Human +DTXSID2046832 Css NA 0.07274 mg/L PBTK NA 50% Human Human +DTXSID2046832 Css NA 0.4852 mg/L PBTK NA 95% Human Human +DTXSID2046832 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046832 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046832 Vd NA 1.028 L/kg 1compartment NA NA Rat Human DTXSID2046832 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046832 TK.Half.Life NA 3.616 hours 1compartment NA NA Rat Human -DTXSID2046832 Css NA 0.1175 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046832 Css NA 0.8114 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046832 Css NA 0.09982 mg/L PBTK NA 50% Rat Human -DTXSID2046832 Css NA 0.5648 mg/L PBTK NA 95% Rat Human -DTXSID2046834 Clint NA 67.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046834 Fup NA 0.3352 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046834 Vd NA 73.89 L/kg 1compartment NA NA Human Human -DTXSID2046834 Days.Css NA 161 Days PBTK NA NA Human Human -DTXSID2046834 TK.Half.Life NA 697 hours 1compartment NA NA Human Human -DTXSID2046834 Css NA 0.0914 mg/L 3compartmentss NA 50% Human Human -DTXSID2046834 Css NA 0.5626 mg/L 3compartmentss NA 95% Human Human -DTXSID2046834 Css NA 0.7902 mg/L PBTK NA 50% Human Human -DTXSID2046834 Css NA 4.366 mg/L PBTK NA 95% Human Human -DTXSID2046834 Clint NA 67.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046834 Fup NA 0.3352 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046834 Vd NA 63.2 L/kg 1compartment NA NA Rat Human -DTXSID2046834 Days.Css NA 104 Days PBTK NA NA Rat Human -DTXSID2046834 TK.Half.Life NA 101 hours 1compartment NA NA Rat Human -DTXSID2046834 Css NA 0.04654 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046834 Css NA 0.2091 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046834 Css NA 0.4242 mg/L PBTK NA 50% Rat Human -DTXSID2046834 Css NA 1.934 mg/L PBTK NA 95% Rat Human -DTXSID2046836 Clint NA 26.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046836 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046836 Vd NA 2.45 L/kg 1compartment NA NA Human Human -DTXSID2046836 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046836 TK.Half.Life NA 1.312 hours 1compartment NA NA Human Human -DTXSID2046836 Css NA 0.01529 mg/L 3compartmentss NA 50% Human Human -DTXSID2046836 Css NA 0.2107 mg/L 3compartmentss NA 95% Human Human -DTXSID2046836 Css NA 0.01665 mg/L PBTK NA 50% Human Human -DTXSID2046836 Css NA 0.1874 mg/L PBTK NA 95% Human Human -DTXSID2046836 Clint NA 26.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046836 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046836 Vd NA 2.477 L/kg 1compartment NA NA Rat Human +DTXSID2046832 TK.Half.Life NA 0.9134 hours 1compartment NA NA Rat Human +DTXSID2046832 Css NA 0.01237 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046832 Css NA 0.06884 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046832 Css NA 0.009101 mg/L PBTK NA 50% Rat Human +DTXSID2046832 Css NA 0.04635 mg/L PBTK NA 95% Rat Human +DTXSID2046836 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046836 Fup 0.614 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046836 Vd NA 2.02 L/kg 1compartment NA NA Human Human +DTXSID2046836 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2046836 TK.Half.Life NA 21.29 hours 1compartment NA NA Human Human +DTXSID2046836 Css NA 0.9224 mg/L 3compartmentss NA 50% Human Human +DTXSID2046836 Css NA 7.406 mg/L 3compartmentss NA 95% Human Human +DTXSID2046836 Css NA 0.9394 mg/L PBTK NA 50% Human Human +DTXSID2046836 Css NA 5.069 mg/L PBTK NA 95% Human Human +DTXSID2046836 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046836 Fup 0.614 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046836 Vd NA 2.031 L/kg 1compartment NA NA Rat Human DTXSID2046836 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046836 TK.Half.Life NA 0.6454 hours 1compartment NA NA Rat Human -DTXSID2046836 Css NA 0.00757 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046836 Css NA 0.08411 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046836 Css NA 0.008356 mg/L PBTK NA 50% Rat Human -DTXSID2046836 Css NA 0.07143 mg/L PBTK NA 95% Rat Human -DTXSID2046880 Clint NA 142.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2046836 TK.Half.Life NA 7.294 hours 1compartment NA NA Rat Human +DTXSID2046836 Css NA 0.05467 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046836 Css NA 0.4227 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046836 Css NA 0.05666 mg/L PBTK NA 50% Rat Human +DTXSID2046836 Css NA 0.2771 mg/L PBTK NA 95% Rat Human +DTXSID2046880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2046880 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2046880 Vd NA 1.403 L/kg 1compartment NA NA Human Human +DTXSID2046880 Vd NA 2.15 L/kg 1compartment NA NA Human Human DTXSID2046880 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046880 TK.Half.Life NA 1.843 hours 1compartment NA NA Human Human -DTXSID2046880 Css NA 0.0782 mg/L 3compartmentss NA 50% Human Human -DTXSID2046880 Css NA 0.6325 mg/L 3compartmentss NA 95% Human Human -DTXSID2046880 Css NA 0.05122 mg/L PBTK NA 50% Human Human -DTXSID2046880 Css NA 0.3915 mg/L PBTK NA 95% Human Human -DTXSID2046880 Clint NA 142.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2046880 TK.Half.Life NA 7.753 hours 1compartment NA NA Human Human +DTXSID2046880 Css NA 0.3621 mg/L 3compartmentss NA 50% Human Human +DTXSID2046880 Css NA 2.901 mg/L 3compartmentss NA 95% Human Human +DTXSID2046880 Css NA 0.2552 mg/L PBTK NA 50% Human Human +DTXSID2046880 Css NA 1.885 mg/L PBTK NA 95% Human Human +DTXSID2046880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2046880 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2046880 Vd NA 1.137 L/kg 1compartment NA NA Rat Human +DTXSID2046880 Vd NA 1.795 L/kg 1compartment NA NA Rat Human DTXSID2046880 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046880 TK.Half.Life NA 0.7365 hours 1compartment NA NA Rat Human -DTXSID2046880 Css NA 0.0443 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046880 Css NA 0.3084 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046880 Css NA 0.02736 mg/L PBTK NA 50% Rat Human -DTXSID2046880 Css NA 0.1799 mg/L PBTK NA 95% Rat Human -DTXSID2046882 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046882 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046882 Vd NA 0.7322 L/kg 1compartment NA NA Human Human +DTXSID2046880 TK.Half.Life NA 3.203 hours 1compartment NA NA Rat Human +DTXSID2046880 Css NA 0.01759 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046880 Css NA 0.1565 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046880 Css NA 0.01232 mg/L PBTK NA 50% Rat Human +DTXSID2046880 Css NA 0.09987 mg/L PBTK NA 95% Rat Human +DTXSID2046882 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046882 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046882 Vd NA 0.6425 L/kg 1compartment NA NA Human Human DTXSID2046882 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046882 TK.Half.Life NA 4.738 hours 1compartment NA NA Human Human -DTXSID2046882 Css NA 0.8392 mg/L 3compartmentss NA 50% Human Human -DTXSID2046882 Css NA 5.532 mg/L 3compartmentss NA 95% Human Human -DTXSID2046882 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID2046882 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID2046882 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046882 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046882 Vd NA 0.7766 L/kg 1compartment NA NA Rat Human +DTXSID2046882 TK.Half.Life NA 5.177 hours 1compartment NA NA Human Human +DTXSID2046882 Css NA 0.8666 mg/L 3compartmentss NA 50% Human Human +DTXSID2046882 Css NA 4.968 mg/L 3compartmentss NA 95% Human Human +DTXSID2046882 Css NA 0.6936 mg/L PBTK NA 50% Human Human +DTXSID2046882 Css NA 3.236 mg/L PBTK NA 95% Human Human +DTXSID2046882 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046882 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046882 Vd NA 0.6809 L/kg 1compartment NA NA Rat Human DTXSID2046882 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046882 TK.Half.Life NA 1.712 hours 1compartment NA NA Rat Human -DTXSID2046882 Css NA 0.2108 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046882 Css NA 1.312 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046882 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID2046882 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID2046886 Clint NA 17.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046886 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046886 Vd NA 2.77 L/kg 1compartment NA NA Human Human -DTXSID2046886 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID2046886 TK.Half.Life NA 55.72 hours 1compartment NA NA Human Human -DTXSID2046886 Css NA 2.746 mg/L 3compartmentss NA 50% Human Human -DTXSID2046886 Css NA 19.52 mg/L 3compartmentss NA 95% Human Human -DTXSID2046886 Css NA 1.849 mg/L PBTK NA 50% Human Human -DTXSID2046886 Css NA 12.72 mg/L PBTK NA 95% Human Human -DTXSID2046886 Clint NA 17.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046886 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046886 Vd NA 2.069 L/kg 1compartment NA NA Rat Human -DTXSID2046886 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2046886 TK.Half.Life NA 11.1 hours 1compartment NA NA Rat Human -DTXSID2046886 Css NA 1.534 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046886 Css NA 8.552 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046886 Css NA 0.9802 mg/L PBTK NA 50% Rat Human -DTXSID2046886 Css NA 5.387 mg/L PBTK NA 95% Rat Human -DTXSID2046888 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2046882 TK.Half.Life NA 1.87 hours 1compartment NA NA Rat Human +DTXSID2046882 Css NA 0.01614 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046882 Css NA 0.1218 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046882 Css NA 0.01229 mg/L PBTK NA 50% Rat Human +DTXSID2046882 Css NA 0.07723 mg/L PBTK NA 95% Rat Human +DTXSID2046886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046886 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046886 Vd NA 0.8902 L/kg 1compartment NA NA Human Human +DTXSID2046886 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046886 TK.Half.Life NA 1.468 hours 1compartment NA NA Human Human +DTXSID2046886 Css NA 0.1053 mg/L 3compartmentss NA 50% Human Human +DTXSID2046886 Css NA 0.7923 mg/L 3compartmentss NA 95% Human Human +DTXSID2046886 Css NA 0.07503 mg/L PBTK NA 50% Human Human +DTXSID2046886 Css NA 0.5268 mg/L PBTK NA 95% Human Human +DTXSID2046886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046886 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046886 Vd NA 0.8821 L/kg 1compartment NA NA Rat Human +DTXSID2046886 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2046886 TK.Half.Life NA 0.8161 hours 1compartment NA NA Rat Human +DTXSID2046886 Css NA 0.01356 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046886 Css NA 0.07265 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046886 Css NA 0.009518 mg/L PBTK NA 50% Rat Human +DTXSID2046886 Css NA 0.04753 mg/L PBTK NA 95% Rat Human +DTXSID2046888 Clint 51 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID2046888 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2046888 Vd NA 1.904 L/kg 1compartment NA NA Human Human -DTXSID2046888 Days.Css NA 106 Days PBTK NA NA Human Human -DTXSID2046888 TK.Half.Life NA 444.9 hours 1compartment NA NA Human Human -DTXSID2046888 Css NA 33.5 mg/L 3compartmentss NA 50% Human Human -DTXSID2046888 Css NA 136 mg/L 3compartmentss NA 95% Human Human -DTXSID2046888 Css NA 21.98 mg/L PBTK NA 50% Human Human -DTXSID2046888 Css NA 81.81 mg/L PBTK NA 95% Human Human -DTXSID2046888 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2046888 Vd NA 1.86 L/kg 1compartment NA NA Human Human +DTXSID2046888 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2046888 TK.Half.Life NA 5.067 hours 1compartment NA NA Human Human +DTXSID2046888 Css NA 0.2928 mg/L 3compartmentss NA 50% Human Human +DTXSID2046888 Css NA 2.364 mg/L 3compartmentss NA 95% Human Human +DTXSID2046888 Css NA 0.1908 mg/L PBTK NA 50% Human Human +DTXSID2046888 Css NA 1.469 mg/L PBTK NA 95% Human Human +DTXSID2046888 Clint 51 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID2046888 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2046888 Vd NA 1.423 L/kg 1compartment NA NA Rat Human -DTXSID2046888 Days.Css NA 24 Days PBTK NA NA Rat Human -DTXSID2046888 TK.Half.Life NA 74.78 hours 1compartment NA NA Rat Human -DTXSID2046888 Css NA 9.335 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046888 Css NA 30.84 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046888 Css NA 5.754 mg/L PBTK NA 50% Rat Human -DTXSID2046888 Css NA 17.43 mg/L PBTK NA 95% Rat Human -DTXSID2046911 Clint NA 17.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046911 Fup NA 0.2955 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046911 Vd NA 2.157 L/kg 1compartment NA NA Human Human +DTXSID2046888 Vd NA 1.39 L/kg 1compartment NA NA Rat Human +DTXSID2046888 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2046888 TK.Half.Life NA 1.729 hours 1compartment NA NA Rat Human +DTXSID2046888 Css NA 0.03826 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046888 Css NA 0.2454 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046888 Css NA 0.02445 mg/L PBTK NA 50% Rat Human +DTXSID2046888 Css NA 0.1493 mg/L PBTK NA 95% Rat Human +DTXSID2046911 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046911 Fup 0.456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046911 Vd NA 1.142 L/kg 1compartment NA NA Human Human DTXSID2046911 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046911 TK.Half.Life NA 2.799 hours 1compartment NA NA Human Human -DTXSID2046911 Css NA 0.07145 mg/L 3compartmentss NA 50% Human Human -DTXSID2046911 Css NA 0.5509 mg/L 3compartmentss NA 95% Human Human -DTXSID2046911 Css NA 0.0647 mg/L PBTK NA 50% Human Human -DTXSID2046911 Css NA 0.4228 mg/L PBTK NA 95% Human Human -DTXSID2046911 Clint NA 17.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046911 Fup NA 0.2955 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046911 Vd NA 2.088 L/kg 1compartment NA NA Rat Human +DTXSID2046911 TK.Half.Life NA 2.044 hours 1compartment NA NA Human Human +DTXSID2046911 Css NA 0.1312 mg/L 3compartmentss NA 50% Human Human +DTXSID2046911 Css NA 0.9248 mg/L 3compartmentss NA 95% Human Human +DTXSID2046911 Css NA 0.1087 mg/L PBTK NA 50% Human Human +DTXSID2046911 Css NA 0.6475 mg/L PBTK NA 95% Human Human +DTXSID2046911 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046911 Fup 0.456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046911 Vd NA 1.154 L/kg 1compartment NA NA Rat Human DTXSID2046911 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046911 TK.Half.Life NA 1.459 hours 1compartment NA NA Rat Human -DTXSID2046911 Css NA 0.03845 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046911 Css NA 0.2184 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046911 Css NA 0.03388 mg/L PBTK NA 50% Rat Human -DTXSID2046911 Css NA 0.161 mg/L PBTK NA 95% Rat Human -DTXSID2046913 Clint NA 38.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046913 Fup NA 0.0874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046913 Vd NA 2.837 L/kg 1compartment NA NA Human Human -DTXSID2046913 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046913 TK.Half.Life NA 9.857 hours 1compartment NA NA Human Human -DTXSID2046913 Css NA 0.3608 mg/L 3compartmentss NA 50% Human Human -DTXSID2046913 Css NA 2.45 mg/L 3compartmentss NA 95% Human Human -DTXSID2046913 Css NA 0.2582 mg/L PBTK NA 50% Human Human -DTXSID2046913 Css NA 1.64 mg/L PBTK NA 95% Human Human -DTXSID2046913 Clint NA 38.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046913 Fup NA 0.0874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046913 Vd NA 2.204 L/kg 1compartment NA NA Rat Human +DTXSID2046911 TK.Half.Life NA 1.153 hours 1compartment NA NA Rat Human +DTXSID2046911 Css NA 0.01488 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046911 Css NA 0.08558 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046911 Css NA 0.01232 mg/L PBTK NA 50% Rat Human +DTXSID2046911 Css NA 0.05708 mg/L PBTK NA 95% Rat Human +DTXSID2046913 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046913 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046913 Vd NA 2.255 L/kg 1compartment NA NA Human Human +DTXSID2046913 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2046913 TK.Half.Life NA 13.37 hours 1compartment NA NA Human Human +DTXSID2046913 Css NA 0.6622 mg/L 3compartmentss NA 50% Human Human +DTXSID2046913 Css NA 4.367 mg/L 3compartmentss NA 95% Human Human +DTXSID2046913 Css NA 0.4953 mg/L PBTK NA 50% Human Human +DTXSID2046913 Css NA 2.951 mg/L PBTK NA 95% Human Human +DTXSID2046913 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046913 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046913 Vd NA 1.882 L/kg 1compartment NA NA Rat Human DTXSID2046913 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046913 TK.Half.Life NA 2.522 hours 1compartment NA NA Rat Human -DTXSID2046913 Css NA 0.2009 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046913 Css NA 1.087 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046913 Css NA 0.1372 mg/L PBTK NA 50% Rat Human -DTXSID2046913 Css NA 0.722 mg/L PBTK NA 95% Rat Human -DTXSID2046915 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046915 Fup NA 0.538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2046915 Vd NA 0.35 L/kg 1compartment NA NA Human Human +DTXSID2046913 TK.Half.Life NA 5.131 hours 1compartment NA NA Rat Human +DTXSID2046913 Css NA 0.08065 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046913 Css NA 0.3813 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046913 Css NA 0.06 mg/L PBTK NA 50% Rat Human +DTXSID2046913 Css NA 0.2503 mg/L PBTK NA 95% Rat Human +DTXSID2046915 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046915 Fup 0.57 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046915 Vd NA 0.3596 L/kg 1compartment NA NA Human Human DTXSID2046915 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2046915 TK.Half.Life NA 4.209 hours 1compartment NA NA Human Human -DTXSID2046915 Css NA 1.54 mg/L 3compartmentss NA 50% Human Human -DTXSID2046915 Css NA 8.535 mg/L 3compartmentss NA 95% Human Human -DTXSID2046915 Css NA 1.064 mg/L PBTK NA 50% Human Human -DTXSID2046915 Css NA 5.109 mg/L PBTK NA 95% Human Human -DTXSID2046915 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046915 Fup NA 0.538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2046915 Vd NA 0.368 L/kg 1compartment NA NA Rat Human +DTXSID2046915 TK.Half.Life NA 4.082 hours 1compartment NA NA Human Human +DTXSID2046915 Css NA 0.7938 mg/L 3compartmentss NA 50% Human Human +DTXSID2046915 Css NA 5.296 mg/L 3compartmentss NA 95% Human Human +DTXSID2046915 Css NA 0.5545 mg/L PBTK NA 50% Human Human +DTXSID2046915 Css NA 3.21 mg/L PBTK NA 95% Human Human +DTXSID2046915 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046915 Fup 0.57 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046915 Vd NA 0.3784 L/kg 1compartment NA NA Rat Human DTXSID2046915 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2046915 TK.Half.Life NA 1.508 hours 1compartment NA NA Rat Human -DTXSID2046915 Css NA 0.4132 mg/L 3compartmentss NA 50% Rat Human -DTXSID2046915 Css NA 2.005 mg/L 3compartmentss NA 95% Rat Human -DTXSID2046915 Css NA 0.2706 mg/L PBTK NA 50% Rat Human -DTXSID2046915 Css NA 1.138 mg/L PBTK NA 95% Rat Human -DTXSID2047060 Clint NA 182.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047060 Fup NA 0.4752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047060 Vd NA 1.98 L/kg 1compartment NA NA Human Human +DTXSID2046915 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human +DTXSID2046915 Css NA 0.00426 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046915 Css NA 0.0279 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046915 Css NA 0.002816 mg/L PBTK NA 50% Rat Human +DTXSID2046915 Css NA 0.01616 mg/L PBTK NA 95% Rat Human +DTXSID2046919 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046919 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2046919 Vd NA 2.63 L/kg 1compartment NA NA Human Human +DTXSID2046919 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID2046919 TK.Half.Life NA 44.92 hours 1compartment NA NA Human Human +DTXSID2046919 Css NA 2.356 mg/L 3compartmentss NA 50% Human Human +DTXSID2046919 Css NA 16.81 mg/L 3compartmentss NA 95% Human Human +DTXSID2046919 Css NA 1.565 mg/L PBTK NA 50% Human Human +DTXSID2046919 Css NA 10.84 mg/L PBTK NA 95% Human Human +DTXSID2046919 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046919 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2046919 Vd NA 1.961 L/kg 1compartment NA NA Rat Human +DTXSID2046919 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID2046919 TK.Half.Life NA 10.07 hours 1compartment NA NA Rat Human +DTXSID2046919 Css NA 0.303 mg/L 3compartmentss NA 50% Rat Human +DTXSID2046919 Css NA 1.887 mg/L 3compartmentss NA 95% Rat Human +DTXSID2046919 Css NA 0.1986 mg/L PBTK NA 50% Rat Human +DTXSID2046919 Css NA 1.175 mg/L PBTK NA 95% Rat Human +DTXSID2047060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047060 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047060 Vd NA 1.556 L/kg 1compartment NA NA Human Human DTXSID2047060 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047060 TK.Half.Life NA 1.413 hours 1compartment NA NA Human Human -DTXSID2047060 Css NA 0.007052 mg/L 3compartmentss NA 50% Human Human -DTXSID2047060 Css NA 0.0577 mg/L 3compartmentss NA 95% Human Human -DTXSID2047060 Css NA 0.005774 mg/L PBTK NA 50% Human Human -DTXSID2047060 Css NA 0.04174 mg/L PBTK NA 95% Human Human -DTXSID2047060 Clint NA 182.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047060 Fup NA 0.4752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047060 Vd NA 1.597 L/kg 1compartment NA NA Rat Human +DTXSID2047060 TK.Half.Life NA 2.279 hours 1compartment NA NA Human Human +DTXSID2047060 Css NA 0.08697 mg/L 3compartmentss NA 50% Human Human +DTXSID2047060 Css NA 0.611 mg/L 3compartmentss NA 95% Human Human +DTXSID2047060 Css NA 0.06503 mg/L PBTK NA 50% Human Human +DTXSID2047060 Css NA 0.4207 mg/L PBTK NA 95% Human Human +DTXSID2047060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047060 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047060 Vd NA 1.246 L/kg 1compartment NA NA Rat Human DTXSID2047060 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047060 TK.Half.Life NA 0.4937 hours 1compartment NA NA Rat Human -DTXSID2047060 Css NA 0.003839 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047060 Css NA 0.02658 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047060 Css NA 0.003066 mg/L PBTK NA 50% Rat Human -DTXSID2047060 Css NA 0.01896 mg/L PBTK NA 95% Rat Human -DTXSID2047062 Clint NA 0.6271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047062 Fup NA 0.7333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047062 Vd NA 1.272 L/kg 1compartment NA NA Human Human +DTXSID2047060 TK.Half.Life NA 0.8883 hours 1compartment NA NA Rat Human +DTXSID2047060 Css NA 0.01079 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047060 Css NA 0.05872 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047060 Css NA 0.008044 mg/L PBTK NA 50% Rat Human +DTXSID2047060 Css NA 0.03985 mg/L PBTK NA 95% Rat Human +DTXSID2047062 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047062 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047062 Vd NA 1.131 L/kg 1compartment NA NA Human Human DTXSID2047062 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047062 TK.Half.Life NA 6.096 hours 1compartment NA NA Human Human -DTXSID2047062 Css NA 0.4825 mg/L 3compartmentss NA 50% Human Human -DTXSID2047062 Css NA 3.288 mg/L 3compartmentss NA 95% Human Human -DTXSID2047062 Css NA 0.4322 mg/L PBTK NA 50% Human Human -DTXSID2047062 Css NA 2.158 mg/L PBTK NA 95% Human Human -DTXSID2047062 Clint NA 0.6271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047062 Fup NA 0.7333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047062 Vd NA 1.161 L/kg 1compartment NA NA Rat Human +DTXSID2047062 TK.Half.Life NA 1.091 hours 1compartment NA NA Human Human +DTXSID2047062 Css NA 0.02995 mg/L 3compartmentss NA 50% Human Human +DTXSID2047062 Css NA 0.302 mg/L 3compartmentss NA 95% Human Human +DTXSID2047062 Css NA 0.02448 mg/L PBTK NA 50% Human Human +DTXSID2047062 Css NA 0.2153 mg/L PBTK NA 95% Human Human +DTXSID2047062 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047062 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047062 Vd NA 1.01 L/kg 1compartment NA NA Rat Human DTXSID2047062 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047062 TK.Half.Life NA 2.383 hours 1compartment NA NA Rat Human -DTXSID2047062 Css NA 0.1711 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047062 Css NA 1.154 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047062 Css NA 0.1497 mg/L PBTK NA 50% Rat Human -DTXSID2047062 Css NA 0.7097 mg/L PBTK NA 95% Rat Human -DTXSID2047064 Clint NA 0.2599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047064 Fup NA 0.1166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047064 Vd NA 0.3126 L/kg 1compartment NA NA Human Human -DTXSID2047064 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2047064 TK.Half.Life NA 12.15 hours 1compartment NA NA Human Human -DTXSID2047064 Css NA 5.808 mg/L 3compartmentss NA 50% Human Human -DTXSID2047064 Css NA 27.67 mg/L 3compartmentss NA 95% Human Human -DTXSID2047064 Css NA 3.65 mg/L PBTK NA 50% Human Human -DTXSID2047064 Css NA 16.44 mg/L PBTK NA 95% Human Human -DTXSID2047064 Clint NA 0.2599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047064 Fup NA 0.1166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047064 Vd NA 0.3093 L/kg 1compartment NA NA Rat Human +DTXSID2047062 TK.Half.Life NA 0.483 hours 1compartment NA NA Rat Human +DTXSID2047062 Css NA 0.00105 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047062 Css NA 0.01241 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047062 Css NA 0.0008505 mg/L PBTK NA 50% Rat Human +DTXSID2047062 Css NA 0.008436 mg/L PBTK NA 95% Rat Human +DTXSID2047064 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047064 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047064 Vd NA 0.495 L/kg 1compartment NA NA Human Human +DTXSID2047064 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2047064 TK.Half.Life NA 0.6348 hours 1compartment NA NA Human Human +DTXSID2047064 Css NA 0.06405 mg/L 3compartmentss NA 50% Human Human +DTXSID2047064 Css NA 0.5142 mg/L 3compartmentss NA 95% Human Human +DTXSID2047064 Css NA 0.04658 mg/L PBTK NA 50% Human Human +DTXSID2047064 Css NA 0.3428 mg/L PBTK NA 95% Human Human +DTXSID2047064 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047064 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047064 Vd NA 0.4931 L/kg 1compartment NA NA Rat Human DTXSID2047064 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047064 TK.Half.Life NA 4.84 hours 1compartment NA NA Rat Human -DTXSID2047064 Css NA 1.969 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047064 Css NA 7.917 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047064 Css NA 1.16 mg/L PBTK NA 50% Rat Human -DTXSID2047064 Css NA 4.378 mg/L PBTK NA 95% Rat Human -DTXSID2047066 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047066 Fup NA 0.9545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047066 Vd NA 1.187 L/kg 1compartment NA NA Human Human +DTXSID2047064 TK.Half.Life NA 0.3362 hours 1compartment NA NA Rat Human +DTXSID2047064 Css NA 0.008178 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047064 Css NA 0.04738 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047064 Css NA 0.005912 mg/L PBTK NA 50% Rat Human +DTXSID2047064 Css NA 0.03125 mg/L PBTK NA 95% Rat Human +DTXSID2047066 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047066 Fup 0.592 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047066 Vd NA 0.9822 L/kg 1compartment NA NA Human Human DTXSID2047066 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047066 TK.Half.Life NA 8.36 hours 1compartment NA NA Human Human -DTXSID2047066 Css NA 0.8336 mg/L 3compartmentss NA 50% Human Human -DTXSID2047066 Css NA 4.844 mg/L 3compartmentss NA 95% Human Human -DTXSID2047066 Css NA 0.7553 mg/L PBTK NA 50% Human Human -DTXSID2047066 Css NA 3.314 mg/L PBTK NA 95% Human Human -DTXSID2047066 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047066 Fup NA 0.9545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047066 Vd NA 1.141 L/kg 1compartment NA NA Rat Human +DTXSID2047066 TK.Half.Life NA 0.8792 hours 1compartment NA NA Human Human +DTXSID2047066 Css NA 0.03256 mg/L 3compartmentss NA 50% Human Human +DTXSID2047066 Css NA 0.3627 mg/L 3compartmentss NA 95% Human Human +DTXSID2047066 Css NA 0.02684 mg/L PBTK NA 50% Human Human +DTXSID2047066 Css NA 0.2523 mg/L PBTK NA 95% Human Human +DTXSID2047066 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047066 Fup 0.592 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047066 Vd NA 0.9208 L/kg 1compartment NA NA Rat Human DTXSID2047066 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047066 TK.Half.Life NA 2.66 hours 1compartment NA NA Rat Human -DTXSID2047066 Css NA 0.209 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047066 Css NA 1.201 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047066 Css NA 0.1863 mg/L PBTK NA 50% Rat Human -DTXSID2047066 Css NA 0.7526 mg/L PBTK NA 95% Rat Human +DTXSID2047066 TK.Half.Life NA 0.4077 hours 1compartment NA NA Rat Human +DTXSID2047066 Css NA 0.003958 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047066 Css NA 0.03823 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047066 Css NA 0.003308 mg/L PBTK NA 50% Rat Human +DTXSID2047066 Css NA 0.02576 mg/L PBTK NA 95% Rat Human +DTXSID2047068 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047068 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047068 Vd NA 2.955 L/kg 1compartment NA NA Human Human +DTXSID2047068 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2047068 TK.Half.Life NA 23.56 hours 1compartment NA NA Human Human +DTXSID2047068 Css NA 0.8942 mg/L 3compartmentss NA 50% Human Human +DTXSID2047068 Css NA 5.876 mg/L 3compartmentss NA 95% Human Human +DTXSID2047068 Css NA 0.6264 mg/L PBTK NA 50% Human Human +DTXSID2047068 Css NA 3.948 mg/L PBTK NA 95% Human Human +DTXSID2047068 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047068 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047068 Vd NA 2.221 L/kg 1compartment NA NA Rat Human +DTXSID2047068 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2047068 TK.Half.Life NA 4.232 hours 1compartment NA NA Rat Human +DTXSID2047068 Css NA 0.1152 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047068 Css NA 0.6198 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047068 Css NA 0.0799 mg/L PBTK NA 50% Rat Human +DTXSID2047068 Css NA 0.42 mg/L PBTK NA 95% Rat Human DTXSID2047145 Clint NA 0.004945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2047145 Fup NA 0.4383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047145 Vd NA 0.4233 L/kg 1compartment NA NA Human Human +DTXSID2047145 Vd NA 0.4498 L/kg 1compartment NA NA Human Human DTXSID2047145 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047145 TK.Half.Life NA 6.194 hours 1compartment NA NA Human Human -DTXSID2047145 Css NA 1.687 mg/L 3compartmentss NA 50% Human Human -DTXSID2047145 Css NA 7.83 mg/L 3compartmentss NA 95% Human Human -DTXSID2047145 Css NA 1.212 mg/L PBTK NA 50% Human Human -DTXSID2047145 Css NA 4.842 mg/L PBTK NA 95% Human Human +DTXSID2047145 TK.Half.Life NA 6.589 hours 1compartment NA NA Human Human +DTXSID2047145 Css NA 1.418 mg/L 3compartmentss NA 50% Human Human +DTXSID2047145 Css NA 6.745 mg/L 3compartmentss NA 95% Human Human +DTXSID2047145 Css NA 1.026 mg/L PBTK NA 50% Human Human +DTXSID2047145 Css NA 4.21 mg/L PBTK NA 95% Human Human DTXSID2047145 Clint NA 0.004945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2047145 Fup NA 0.4383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047145 Vd NA 0.4286 L/kg 1compartment NA NA Rat Human +DTXSID2047145 Vd NA 0.4528 L/kg 1compartment NA NA Rat Human DTXSID2047145 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047145 TK.Half.Life NA 2.148 hours 1compartment NA NA Rat Human -DTXSID2047145 Css NA 0.4708 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047145 Css NA 1.893 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047145 Css NA 0.32 mg/L PBTK NA 50% Rat Human -DTXSID2047145 Css NA 1.099 mg/L PBTK NA 95% Rat Human -DTXSID2047149 Clint NA 2.366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047149 Fup NA 0.3348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047149 Vd NA 2.583 L/kg 1compartment NA NA Human Human -DTXSID2047149 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2047149 TK.Half.Life NA 27.07 hours 1compartment NA NA Human Human -DTXSID2047149 Css NA 1.139 mg/L 3compartmentss NA 50% Human Human -DTXSID2047149 Css NA 5.056 mg/L 3compartmentss NA 95% Human Human -DTXSID2047149 Css NA 0.8637 mg/L PBTK NA 50% Human Human -DTXSID2047149 Css NA 3.528 mg/L PBTK NA 95% Human Human -DTXSID2047149 Clint NA 2.366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047149 Fup NA 0.3348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047149 Vd NA 1.987 L/kg 1compartment NA NA Rat Human -DTXSID2047149 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2047149 TK.Half.Life NA 6.086 hours 1compartment NA NA Rat Human -DTXSID2047149 Css NA 0.5396 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047149 Css NA 1.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047149 Css NA 0.3937 mg/L PBTK NA 50% Rat Human -DTXSID2047149 Css NA 1.083 mg/L PBTK NA 95% Rat Human -DTXSID2047191 Clint NA 21.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047191 Fup NA 0.0216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047191 Vd NA 3.06 L/kg 1compartment NA NA Human Human -DTXSID2047191 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID2047191 TK.Half.Life NA 69.82 hours 1compartment NA NA Human Human -DTXSID2047191 Css NA 2.846 mg/L 3compartmentss NA 50% Human Human -DTXSID2047191 Css NA 18.17 mg/L 3compartmentss NA 95% Human Human -DTXSID2047191 Css NA 1.963 mg/L PBTK NA 50% Human Human -DTXSID2047191 Css NA 12.17 mg/L PBTK NA 95% Human Human -DTXSID2047191 Clint NA 21.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047191 Fup NA 0.0216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047191 Vd NA 2.291 L/kg 1compartment NA NA Rat Human -DTXSID2047191 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID2047191 TK.Half.Life NA 10.28 hours 1compartment NA NA Rat Human -DTXSID2047191 Css NA 1.589 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047191 Css NA 8.645 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047191 Css NA 1.044 mg/L PBTK NA 50% Rat Human -DTXSID2047191 Css NA 5.584 mg/L PBTK NA 95% Rat Human -DTXSID2047193 Clint NA 12.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047193 Fup NA 0.1974 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047193 Vd NA 2.94 L/kg 1compartment NA NA Human Human -DTXSID2047193 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2047193 TK.Half.Life NA 24.75 hours 1compartment NA NA Human Human -DTXSID2047193 Css NA 0.929 mg/L 3compartmentss NA 50% Human Human -DTXSID2047193 Css NA 5.43 mg/L 3compartmentss NA 95% Human Human -DTXSID2047193 Css NA 0.6618 mg/L PBTK NA 50% Human Human -DTXSID2047193 Css NA 3.811 mg/L PBTK NA 95% Human Human -DTXSID2047193 Clint NA 12.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047193 Fup NA 0.1974 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047193 Vd NA 2.218 L/kg 1compartment NA NA Rat Human -DTXSID2047193 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2047193 TK.Half.Life NA 4.501 hours 1compartment NA NA Rat Human -DTXSID2047193 Css NA 0.5055 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047193 Css NA 2.299 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047193 Css NA 0.3446 mg/L PBTK NA 50% Rat Human -DTXSID2047193 Css NA 1.529 mg/L PBTK NA 95% Rat Human -DTXSID2047195 Clint NA 0.3629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047195 Fup NA 0.2918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047195 Vd NA 2.638 L/kg 1compartment NA NA Human Human -DTXSID2047195 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID2047195 TK.Half.Life NA 112.8 hours 1compartment NA NA Human Human -DTXSID2047195 Css NA 4.652 mg/L 3compartmentss NA 50% Human Human -DTXSID2047195 Css NA 14.61 mg/L 3compartmentss NA 95% Human Human -DTXSID2047195 Css NA 3.481 mg/L PBTK NA 50% Human Human -DTXSID2047195 Css NA 9.897 mg/L PBTK NA 95% Human Human -DTXSID2047195 Clint NA 0.3629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047195 Fup NA 0.2918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047195 Vd NA 2.018 L/kg 1compartment NA NA Rat Human -DTXSID2047195 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID2047195 TK.Half.Life NA 17.5 hours 1compartment NA NA Rat Human -DTXSID2047195 Css NA 1.652 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047195 Css NA 4.099 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047195 Css NA 1.188 mg/L PBTK NA 50% Rat Human -DTXSID2047195 Css NA 2.562 mg/L PBTK NA 95% Rat Human +DTXSID2047145 TK.Half.Life NA 2.27 hours 1compartment NA NA Rat Human +DTXSID2047145 Css NA 0.02644 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047145 Css NA 0.1744 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047145 Css NA 0.01844 mg/L PBTK NA 50% Rat Human +DTXSID2047145 Css NA 0.1094 mg/L PBTK NA 95% Rat Human +DTXSID2047191 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047191 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047191 Vd NA 3.115 L/kg 1compartment NA NA Human Human +DTXSID2047191 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID2047191 TK.Half.Life NA 92.95 hours 1compartment NA NA Human Human +DTXSID2047191 Css NA 3.468 mg/L 3compartmentss NA 50% Human Human +DTXSID2047191 Css NA 20.69 mg/L 3compartmentss NA 95% Human Human +DTXSID2047191 Css NA 2.391 mg/L PBTK NA 50% Human Human +DTXSID2047191 Css NA 14.27 mg/L PBTK NA 95% Human Human +DTXSID2047191 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047191 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047191 Vd NA 2.333 L/kg 1compartment NA NA Rat Human +DTXSID2047191 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID2047191 TK.Half.Life NA 12.56 hours 1compartment NA NA Rat Human +DTXSID2047191 Css NA 0.4552 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047191 Css NA 2.166 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047191 Css NA 0.3121 mg/L PBTK NA 50% Rat Human +DTXSID2047191 Css NA 1.494 mg/L PBTK NA 95% Rat Human +DTXSID2047193 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047193 Fup 0.259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047193 Vd NA 2.719 L/kg 1compartment NA NA Human Human +DTXSID2047193 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2047193 TK.Half.Life NA 7.529 hours 1compartment NA NA Human Human +DTXSID2047193 Css NA 0.2366 mg/L 3compartmentss NA 50% Human Human +DTXSID2047193 Css NA 1.493 mg/L 3compartmentss NA 95% Human Human +DTXSID2047193 Css NA 0.173 mg/L PBTK NA 50% Human Human +DTXSID2047193 Css NA 1.047 mg/L PBTK NA 95% Human Human +DTXSID2047193 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047193 Fup 0.259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047193 Vd NA 2.07 L/kg 1compartment NA NA Rat Human +DTXSID2047193 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047193 TK.Half.Life NA 1.863 hours 1compartment NA NA Rat Human +DTXSID2047193 Css NA 0.02973 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047193 Css NA 0.1462 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047193 Css NA 0.02176 mg/L PBTK NA 50% Rat Human +DTXSID2047193 Css NA 0.1045 mg/L PBTK NA 95% Rat Human +DTXSID2047195 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047195 Fup 0.0691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047195 Vd NA 2.229 L/kg 1compartment NA NA Human Human +DTXSID2047195 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2047195 TK.Half.Life NA 10.69 hours 1compartment NA NA Human Human +DTXSID2047195 Css NA 0.5446 mg/L 3compartmentss NA 50% Human Human +DTXSID2047195 Css NA 3.618 mg/L 3compartmentss NA 95% Human Human +DTXSID2047195 Css NA 0.3666 mg/L PBTK NA 50% Human Human +DTXSID2047195 Css NA 2.312 mg/L PBTK NA 95% Human Human +DTXSID2047195 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047195 Fup 0.0691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047195 Vd NA 1.675 L/kg 1compartment NA NA Rat Human +DTXSID2047195 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047195 TK.Half.Life NA 3.181 hours 1compartment NA NA Rat Human +DTXSID2047195 Css NA 0.07001 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047195 Css NA 0.3716 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047195 Css NA 0.04652 mg/L PBTK NA 50% Rat Human +DTXSID2047195 Css NA 0.2362 mg/L PBTK NA 95% Rat Human DTXSID2047199 Clint 24.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2047199 Fup 0.0707 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2047199 Vd NA 1.189 L/kg 1compartment NA NA Human Human +DTXSID2047199 Vd NA 1.375 L/kg 1compartment NA NA Human Human DTXSID2047199 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047199 TK.Half.Life NA 3.741 hours 1compartment NA NA Human Human -DTXSID2047199 Css NA 0.3117 mg/L 3compartmentss NA 50% Human Human -DTXSID2047199 Css NA 2.471 mg/L 3compartmentss NA 95% Human Human -DTXSID2047199 Css NA 0.2032 mg/L PBTK NA 50% Human Human -DTXSID2047199 Css NA 1.539 mg/L PBTK NA 95% Human Human +DTXSID2047199 TK.Half.Life NA 4.458 hours 1compartment NA NA Human Human +DTXSID2047199 Css NA 0.3133 mg/L 3compartmentss NA 50% Human Human +DTXSID2047199 Css NA 2.496 mg/L 3compartmentss NA 95% Human Human +DTXSID2047199 Css NA 0.2071 mg/L PBTK NA 50% Human Human +DTXSID2047199 Css NA 1.584 mg/L PBTK NA 95% Human Human DTXSID2047199 Clint 24.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2047199 Fup 0.0707 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2047199 Vd NA 0.91 L/kg 1compartment NA NA Rat Human +DTXSID2047199 Vd NA 1.046 L/kg 1compartment NA NA Rat Human DTXSID2047199 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047199 TK.Half.Life NA 1.559 hours 1compartment NA NA Rat Human -DTXSID2047199 Css NA 0.1768 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047199 Css NA 1.076 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047199 Css NA 0.109 mg/L PBTK NA 50% Rat Human -DTXSID2047199 Css NA 0.6338 mg/L PBTK NA 95% Rat Human -DTXSID2047222 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047222 Fup NA 0.0255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047222 Vd NA 3.223 L/kg 1compartment NA NA Human Human -DTXSID2047222 Days.Css NA 24 Days PBTK NA NA Human Human -DTXSID2047222 TK.Half.Life NA 135.3 hours 1compartment NA NA Human Human -DTXSID2047222 Css NA 4.752 mg/L 3compartmentss NA 50% Human Human -DTXSID2047222 Css NA 27.93 mg/L 3compartmentss NA 95% Human Human -DTXSID2047222 Css NA 3.345 mg/L PBTK NA 50% Human Human -DTXSID2047222 Css NA 19.48 mg/L PBTK NA 95% Human Human -DTXSID2047222 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047222 Fup NA 0.0255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047222 Vd NA 2.418 L/kg 1compartment NA NA Rat Human -DTXSID2047222 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID2047222 TK.Half.Life NA 17.78 hours 1compartment NA NA Rat Human -DTXSID2047222 Css NA 2.765 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047222 Css NA 11.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047222 Css NA 1.854 mg/L PBTK NA 50% Rat Human -DTXSID2047222 Css NA 7.794 mg/L PBTK NA 95% Rat Human +DTXSID2047199 TK.Half.Life NA 1.776 hours 1compartment NA NA Rat Human +DTXSID2047199 Css NA 0.04164 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047199 Css NA 0.2586 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047199 Css NA 0.02684 mg/L PBTK NA 50% Rat Human +DTXSID2047199 Css NA 0.1594 mg/L PBTK NA 95% Rat Human +DTXSID2047222 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047222 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047222 Vd NA 4.755 L/kg 1compartment NA NA Human Human +DTXSID2047222 Days.Css NA 26 Days PBTK NA NA Human Human +DTXSID2047222 TK.Half.Life NA 143 hours 1compartment NA NA Human Human +DTXSID2047222 Css NA 2.994 mg/L 3compartmentss NA 50% Human Human +DTXSID2047222 Css NA 17.42 mg/L 3compartmentss NA 95% Human Human +DTXSID2047222 Css NA 2.392 mg/L PBTK NA 50% Human Human +DTXSID2047222 Css NA 13.63 mg/L PBTK NA 95% Human Human +DTXSID2047222 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047222 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047222 Vd NA 3.623 L/kg 1compartment NA NA Rat Human +DTXSID2047222 Days.Css NA 15 Days PBTK NA NA Rat Human +DTXSID2047222 TK.Half.Life NA 19.35 hours 1compartment NA NA Rat Human +DTXSID2047222 Css NA 0.3862 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047222 Css NA 1.95 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047222 Css NA 0.3078 mg/L PBTK NA 50% Rat Human +DTXSID2047222 Css NA 1.56 mg/L PBTK NA 95% Rat Human DTXSID2047270 Clint 5.31 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2047270 Fup 0.0385 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2047270 Vd NA 2.653 L/kg 1compartment NA NA Human Human -DTXSID2047270 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID2047270 TK.Half.Life NA 53.4 hours 1compartment NA NA Human Human -DTXSID2047270 Css NA 2.38 mg/L 3compartmentss NA 50% Human Human -DTXSID2047270 Css NA 14.43 mg/L 3compartmentss NA 95% Human Human -DTXSID2047270 Css NA 1.683 mg/L PBTK NA 50% Human Human -DTXSID2047270 Css NA 9.653 mg/L PBTK NA 95% Human Human +DTXSID2047270 Vd NA 2.769 L/kg 1compartment NA NA Human Human +DTXSID2047270 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID2047270 TK.Half.Life NA 59.81 hours 1compartment NA NA Human Human +DTXSID2047270 Css NA 2.463 mg/L 3compartmentss NA 50% Human Human +DTXSID2047270 Css NA 15.05 mg/L 3compartmentss NA 95% Human Human +DTXSID2047270 Css NA 1.76 mg/L PBTK NA 50% Human Human +DTXSID2047270 Css NA 10.14 mg/L PBTK NA 95% Human Human DTXSID2047270 Clint 5.31 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2047270 Fup 0.0385 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2047270 Vd NA 2.078 L/kg 1compartment NA NA Rat Human -DTXSID2047270 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2047270 TK.Half.Life NA 14.44 hours 1compartment NA NA Rat Human -DTXSID2047270 Css NA 1.278 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047270 Css NA 5.705 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047270 Css NA 0.8706 mg/L PBTK NA 50% Rat Human -DTXSID2047270 Css NA 3.72 mg/L PBTK NA 95% Rat Human +DTXSID2047270 Vd NA 2.153 L/kg 1compartment NA NA Rat Human +DTXSID2047270 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID2047270 TK.Half.Life NA 14.62 hours 1compartment NA NA Rat Human +DTXSID2047270 Css NA 0.3055 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047270 Css NA 1.405 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047270 Css NA 0.2155 mg/L PBTK NA 50% Rat Human +DTXSID2047270 Css NA 0.9589 mg/L PBTK NA 95% Rat Human DTXSID2047272 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2047272 Fup 0.0645 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2047272 Vd NA 2.399 L/kg 1compartment NA NA Human Human -DTXSID2047272 Days.Css NA 136 Days PBTK NA NA Human Human -DTXSID2047272 TK.Half.Life NA 563.1 hours 1compartment NA NA Human Human -DTXSID2047272 Css NA 3.06 mg/L 3compartmentss NA 50% Human Human -DTXSID2047272 Css NA 15.7 mg/L 3compartmentss NA 95% Human Human -DTXSID2047272 Css NA 2.156 mg/L PBTK NA 50% Human Human -DTXSID2047272 Css NA 10.4 mg/L PBTK NA 95% Human Human +DTXSID2047272 Vd NA 0.2607 L/kg 1compartment NA NA Human Human +DTXSID2047272 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2047272 TK.Half.Life NA 26.15 hours 1compartment NA NA Human Human +DTXSID2047272 Css NA 2.01 mg/L 3compartmentss NA 50% Human Human +DTXSID2047272 Css NA 10.99 mg/L 3compartmentss NA 95% Human Human +DTXSID2047272 Css NA 1.229 mg/L PBTK NA 50% Human Human +DTXSID2047272 Css NA 6.475 mg/L PBTK NA 95% Human Human DTXSID2047272 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2047272 Fup 0.0645 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2047272 Vd NA 1.857 L/kg 1compartment NA NA Rat Human -DTXSID2047272 Days.Css NA 33 Days PBTK NA NA Rat Human -DTXSID2047272 TK.Half.Life NA 83.74 hours 1compartment NA NA Rat Human -DTXSID2047272 Css NA 1.565 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047272 Css NA 5.564 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047272 Css NA 1.046 mg/L PBTK NA 50% Rat Human -DTXSID2047272 Css NA 3.454 mg/L PBTK NA 95% Rat Human -DTXSID2047274 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047274 Fup NA 0.1371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047274 Vd NA 0.4755 L/kg 1compartment NA NA Human Human -DTXSID2047274 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2047274 TK.Half.Life NA 22.82 hours 1compartment NA NA Human Human -DTXSID2047274 Css NA 7.068 mg/L 3compartmentss NA 50% Human Human -DTXSID2047274 Css NA 32.47 mg/L 3compartmentss NA 95% Human Human -DTXSID2047274 Css NA 4.533 mg/L PBTK NA 50% Human Human -DTXSID2047274 Css NA 19.16 mg/L PBTK NA 95% Human Human -DTXSID2047274 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047274 Fup NA 0.1371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047274 Vd NA 0.4221 L/kg 1compartment NA NA Rat Human +DTXSID2047272 Vd NA 0.2641 L/kg 1compartment NA NA Rat Human +DTXSID2047272 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047272 TK.Half.Life NA 9.027 hours 1compartment NA NA Rat Human +DTXSID2047272 Css NA 0.2318 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047272 Css NA 0.9262 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047272 Css NA 0.1366 mg/L PBTK NA 50% Rat Human +DTXSID2047272 Css NA 0.5295 mg/L PBTK NA 95% Rat Human +DTXSID2047274 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047274 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047274 Vd NA 0.6089 L/kg 1compartment NA NA Human Human +DTXSID2047274 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2047274 TK.Half.Life NA 1.686 hours 1compartment NA NA Human Human +DTXSID2047274 Css NA 0.2207 mg/L 3compartmentss NA 50% Human Human +DTXSID2047274 Css NA 1.399 mg/L 3compartmentss NA 95% Human Human +DTXSID2047274 Css NA 0.1538 mg/L PBTK NA 50% Human Human +DTXSID2047274 Css NA 0.9054 mg/L PBTK NA 95% Human Human +DTXSID2047274 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047274 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047274 Vd NA 0.5523 L/kg 1compartment NA NA Rat Human DTXSID2047274 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047274 TK.Half.Life NA 6.816 hours 1compartment NA NA Rat Human -DTXSID2047274 Css NA 1.959 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047274 Css NA 7.598 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047274 Css NA 1.172 mg/L PBTK NA 50% Rat Human -DTXSID2047274 Css NA 4.226 mg/L PBTK NA 95% Rat Human -DTXSID2047276 Clint NA 284.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047276 Fup NA 0.3734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047276 Vd NA 1.658 L/kg 1compartment NA NA Human Human +DTXSID2047274 TK.Half.Life NA 0.8693 hours 1compartment NA NA Rat Human +DTXSID2047274 Css NA 0.009756 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047274 Css NA 0.06982 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047274 Css NA 0.006653 mg/L PBTK NA 50% Rat Human +DTXSID2047274 Css NA 0.04445 mg/L PBTK NA 95% Rat Human +DTXSID2047276 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047276 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047276 Vd NA 1.459 L/kg 1compartment NA NA Human Human DTXSID2047276 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047276 TK.Half.Life NA 1.212 hours 1compartment NA NA Human Human -DTXSID2047276 Css NA 0.005125 mg/L 3compartmentss NA 50% Human Human -DTXSID2047276 Css NA 0.04037 mg/L 3compartmentss NA 95% Human Human -DTXSID2047276 Css NA 0.004058 mg/L PBTK NA 50% Human Human -DTXSID2047276 Css NA 0.02872 mg/L PBTK NA 95% Human Human -DTXSID2047276 Clint NA 284.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047276 Fup NA 0.3734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047276 Vd NA 1.346 L/kg 1compartment NA NA Rat Human +DTXSID2047276 TK.Half.Life NA 4.44 hours 1compartment NA NA Human Human +DTXSID2047276 Css NA 0.2761 mg/L 3compartmentss NA 50% Human Human +DTXSID2047276 Css NA 1.622 mg/L 3compartmentss NA 95% Human Human +DTXSID2047276 Css NA 0.2068 mg/L PBTK NA 50% Human Human +DTXSID2047276 Css NA 1.109 mg/L PBTK NA 95% Human Human +DTXSID2047276 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047276 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047276 Vd NA 1.178 L/kg 1compartment NA NA Rat Human DTXSID2047276 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047276 TK.Half.Life NA 0.4305 hours 1compartment NA NA Rat Human -DTXSID2047276 Css NA 0.002854 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047276 Css NA 0.01875 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047276 Css NA 0.002172 mg/L PBTK NA 50% Rat Human -DTXSID2047276 Css NA 0.01322 mg/L PBTK NA 95% Rat Human -DTXSID2047278 Clint NA 39.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047278 Fup NA 0.0277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047278 Vd NA 0.7576 L/kg 1compartment NA NA Human Human -DTXSID2047278 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047278 TK.Half.Life NA 3.159 hours 1compartment NA NA Human Human -DTXSID2047278 Css NA 0.6056 mg/L 3compartmentss NA 50% Human Human -DTXSID2047278 Css NA 6.363 mg/L 3compartmentss NA 95% Human Human -DTXSID2047278 Css NA 0.3722 mg/L PBTK NA 50% Human Human -DTXSID2047278 Css NA 3.758 mg/L PBTK NA 95% Human Human -DTXSID2047278 Clint NA 39.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047278 Fup NA 0.0277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047278 Vd NA 0.6202 L/kg 1compartment NA NA Rat Human -DTXSID2047278 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047278 TK.Half.Life NA 1.579 hours 1compartment NA NA Rat Human -DTXSID2047278 Css NA 0.3416 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047278 Css NA 2.864 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047278 Css NA 0.1952 mg/L PBTK NA 50% Rat Human -DTXSID2047278 Css NA 1.599 mg/L PBTK NA 95% Rat Human -DTXSID2047301 Clint NA 16.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047301 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047301 Vd NA 0.2632 L/kg 1compartment NA NA Human Human +DTXSID2047276 TK.Half.Life NA 1.814 hours 1compartment NA NA Rat Human +DTXSID2047276 Css NA 0.0323 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047276 Css NA 0.1384 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047276 Css NA 0.02415 mg/L PBTK NA 50% Rat Human +DTXSID2047276 Css NA 0.09399 mg/L PBTK NA 95% Rat Human +DTXSID2047278 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047278 Fup 0.0317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047278 Vd NA 1.088 L/kg 1compartment NA NA Human Human +DTXSID2047278 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2047278 TK.Half.Life NA 19.71 hours 1compartment NA NA Human Human +DTXSID2047278 Css NA 3.013 mg/L 3compartmentss NA 50% Human Human +DTXSID2047278 Css NA 23.84 mg/L 3compartmentss NA 95% Human Human +DTXSID2047278 Css NA 1.887 mg/L PBTK NA 50% Human Human +DTXSID2047278 Css NA 14.27 mg/L PBTK NA 95% Human Human +DTXSID2047278 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047278 Fup 0.0317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047278 Vd NA 0.8653 L/kg 1compartment NA NA Rat Human +DTXSID2047278 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2047278 TK.Half.Life NA 9.039 hours 1compartment NA NA Rat Human +DTXSID2047278 Css NA 0.3708 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047278 Css NA 2.38 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047278 Css NA 0.2244 mg/L PBTK NA 50% Rat Human +DTXSID2047278 Css NA 1.366 mg/L PBTK NA 95% Rat Human +DTXSID2047301 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047301 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047301 Vd NA 0.6416 L/kg 1compartment NA NA Human Human DTXSID2047301 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047301 TK.Half.Life NA 3.114 hours 1compartment NA NA Human Human -DTXSID2047301 Css NA 2.092 mg/L 3compartmentss NA 50% Human Human -DTXSID2047301 Css NA 20.22 mg/L 3compartmentss NA 95% Human Human -DTXSID2047301 Css NA 1.24 mg/L PBTK NA 50% Human Human -DTXSID2047301 Css NA 11.67 mg/L PBTK NA 95% Human Human -DTXSID2047301 Clint NA 16.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047301 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047301 Vd NA 0.2334 L/kg 1compartment NA NA Rat Human +DTXSID2047301 TK.Half.Life NA 1.648 hours 1compartment NA NA Human Human +DTXSID2047301 Css NA 0.2006 mg/L 3compartmentss NA 50% Human Human +DTXSID2047301 Css NA 1.241 mg/L 3compartmentss NA 95% Human Human +DTXSID2047301 Css NA 0.1407 mg/L PBTK NA 50% Human Human +DTXSID2047301 Css NA 0.8007 mg/L PBTK NA 95% Human Human +DTXSID2047301 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047301 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047301 Vd NA 0.5732 L/kg 1compartment NA NA Rat Human DTXSID2047301 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047301 TK.Half.Life NA 1.807 hours 1compartment NA NA Rat Human -DTXSID2047301 Css NA 1.188 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047301 Css NA 8.594 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047301 Css NA 0.6512 mg/L PBTK NA 50% Rat Human -DTXSID2047301 Css NA 4.667 mg/L PBTK NA 95% Rat Human -DTXSID2047303 Clint NA 4.299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047303 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047303 Vd NA 1.431 L/kg 1compartment NA NA Human Human -DTXSID2047303 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2047303 TK.Half.Life NA 32.63 hours 1compartment NA NA Human Human -DTXSID2047303 Css NA 3.796 mg/L 3compartmentss NA 50% Human Human -DTXSID2047303 Css NA 27.16 mg/L 3compartmentss NA 95% Human Human -DTXSID2047303 Css NA 2.404 mg/L PBTK NA 50% Human Human -DTXSID2047303 Css NA 16.32 mg/L PBTK NA 95% Human Human -DTXSID2047303 Clint NA 4.299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047303 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047303 Vd NA 1.072 L/kg 1compartment NA NA Rat Human +DTXSID2047301 TK.Half.Life NA 0.828 hours 1compartment NA NA Rat Human +DTXSID2047301 Css NA 0.008651 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047301 Css NA 0.06512 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047301 Css NA 0.005973 mg/L PBTK NA 50% Rat Human +DTXSID2047301 Css NA 0.04168 mg/L PBTK NA 95% Rat Human +DTXSID2047303 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047303 Fup 0.0812 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047303 Vd NA 2.171 L/kg 1compartment NA NA Human Human +DTXSID2047303 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2047303 TK.Half.Life NA 25.7 hours 1compartment NA NA Human Human +DTXSID2047303 Css NA 1.588 mg/L 3compartmentss NA 50% Human Human +DTXSID2047303 Css NA 9.513 mg/L 3compartmentss NA 95% Human Human +DTXSID2047303 Css NA 1.07 mg/L PBTK NA 50% Human Human +DTXSID2047303 Css NA 6.101 mg/L PBTK NA 95% Human Human +DTXSID2047303 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047303 Fup 0.0812 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047303 Vd NA 1.635 L/kg 1compartment NA NA Rat Human DTXSID2047303 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2047303 TK.Half.Life NA 12.21 hours 1compartment NA NA Rat Human -DTXSID2047303 Css NA 1.967 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047303 Css NA 10.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047303 Css NA 1.167 mg/L PBTK NA 50% Rat Human -DTXSID2047303 Css NA 6.01 mg/L PBTK NA 95% Rat Human -DTXSID2047305 Clint NA 10.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047305 Fup NA 0.1031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047305 Vd NA 0.2936 L/kg 1compartment NA NA Human Human +DTXSID2047303 TK.Half.Life NA 7.495 hours 1compartment NA NA Rat Human +DTXSID2047303 Css NA 0.1954 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047303 Css NA 0.8642 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047303 Css NA 0.1299 mg/L PBTK NA 50% Rat Human +DTXSID2047303 Css NA 0.5359 mg/L PBTK NA 95% Rat Human +DTXSID2047305 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047305 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047305 Vd NA 0.6365 L/kg 1compartment NA NA Human Human DTXSID2047305 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047305 TK.Half.Life NA 1.283 hours 1compartment NA NA Human Human -DTXSID2047305 Css NA 0.6095 mg/L 3compartmentss NA 50% Human Human -DTXSID2047305 Css NA 4.485 mg/L 3compartmentss NA 95% Human Human -DTXSID2047305 Css NA 0.3738 mg/L PBTK NA 50% Human Human -DTXSID2047305 Css NA 2.67 mg/L PBTK NA 95% Human Human -DTXSID2047305 Clint NA 10.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047305 Fup NA 0.1031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047305 Vd NA 0.2919 L/kg 1compartment NA NA Rat Human +DTXSID2047305 TK.Half.Life NA 2.459 hours 1compartment NA NA Human Human +DTXSID2047305 Css NA 0.353 mg/L 3compartmentss NA 50% Human Human +DTXSID2047305 Css NA 2.16 mg/L 3compartmentss NA 95% Human Human +DTXSID2047305 Css NA 0.2366 mg/L PBTK NA 50% Human Human +DTXSID2047305 Css NA 1.38 mg/L PBTK NA 95% Human Human +DTXSID2047305 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047305 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047305 Vd NA 0.5635 L/kg 1compartment NA NA Rat Human DTXSID2047305 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047305 TK.Half.Life NA 0.7797 hours 1compartment NA NA Rat Human -DTXSID2047305 Css NA 0.3358 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047305 Css NA 1.837 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047305 Css NA 0.1939 mg/L PBTK NA 50% Rat Human -DTXSID2047305 Css NA 1.016 mg/L PBTK NA 95% Rat Human +DTXSID2047305 TK.Half.Life NA 1.269 hours 1compartment NA NA Rat Human +DTXSID2047305 Css NA 0.0159 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047305 Css NA 0.1122 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047305 Css NA 0.01052 mg/L PBTK NA 50% Rat Human +DTXSID2047305 Css NA 0.06914 mg/L PBTK NA 95% Rat Human DTXSID2047307 Clint 3.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2047307 Fup 0.00409 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2047307 Vd NA 2.499 L/kg 1compartment NA NA Human Human -DTXSID2047307 Days.Css NA 87 Days PBTK NA NA Human Human -DTXSID2047307 TK.Half.Life NA 382.1 hours 1compartment NA NA Human Human -DTXSID2047307 Css NA 19.73 mg/L 3compartmentss NA 50% Human Human -DTXSID2047307 Css NA 122.3 mg/L 3compartmentss NA 95% Human Human -DTXSID2047307 Css NA 13.1 mg/L PBTK NA 50% Human Human -DTXSID2047307 Css NA 79.34 mg/L PBTK NA 95% Human Human +DTXSID2047307 Vd NA 2.51 L/kg 1compartment NA NA Human Human +DTXSID2047307 Days.Css NA 88 Days PBTK NA NA Human Human +DTXSID2047307 TK.Half.Life NA 384.7 hours 1compartment NA NA Human Human +DTXSID2047307 Css NA 19.19 mg/L 3compartmentss NA 50% Human Human +DTXSID2047307 Css NA 111.7 mg/L 3compartmentss NA 95% Human Human +DTXSID2047307 Css NA 12.87 mg/L PBTK NA 50% Human Human +DTXSID2047307 Css NA 72.75 mg/L PBTK NA 95% Human Human DTXSID2047307 Clint 3.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2047307 Fup 0.00409 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2047307 Vd NA 1.858 L/kg 1compartment NA NA Rat Human -DTXSID2047307 Days.Css NA 45 Days PBTK NA NA Rat Human -DTXSID2047307 TK.Half.Life NA 89.75 hours 1compartment NA NA Rat Human -DTXSID2047307 Css NA 10.72 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047307 Css NA 51.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047307 Css NA 6.76 mg/L PBTK NA 50% Rat Human -DTXSID2047307 Css NA 31.65 mg/L PBTK NA 95% Rat Human -DTXSID2047309 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047309 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047309 Vd NA 1.226 L/kg 1compartment NA NA Human Human -DTXSID2047309 Days.Css NA 195 Days PBTK NA NA Human Human -DTXSID2047309 TK.Half.Life NA 764.2 hours 1compartment NA NA Human Human -DTXSID2047309 Css NA 100 mg/L 3compartmentss NA 50% Human Human -DTXSID2047309 Css NA 559.9 mg/L 3compartmentss NA 95% Human Human -DTXSID2047309 Css NA 61.22 mg/L PBTK NA 50% Human Human -DTXSID2047309 Css NA 324.4 mg/L PBTK NA 95% Human Human -DTXSID2047309 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047309 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047309 Vd NA 0.9056 L/kg 1compartment NA NA Rat Human -DTXSID2047309 Days.Css NA 45 Days PBTK NA NA Rat Human -DTXSID2047309 TK.Half.Life NA 160.3 hours 1compartment NA NA Rat Human -DTXSID2047309 Css NA 28.22 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047309 Css NA 137.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047309 Css NA 16.17 mg/L PBTK NA 50% Rat Human -DTXSID2047309 Css NA 75.35 mg/L PBTK NA 95% Rat Human -DTXSID2047351 Clint NA 317.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047351 Fup NA 0.058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047351 Vd NA 3.481 L/kg 1compartment NA NA Human Human +DTXSID2047307 Vd NA 1.867 L/kg 1compartment NA NA Rat Human +DTXSID2047307 Days.Css NA 46 Days PBTK NA NA Rat Human +DTXSID2047307 TK.Half.Life NA 89.68 hours 1compartment NA NA Rat Human +DTXSID2047307 Css NA 2.434 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047307 Css NA 11.52 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047307 Css NA 1.599 mg/L PBTK NA 50% Rat Human +DTXSID2047307 Css NA 7.383 mg/L PBTK NA 95% Rat Human +DTXSID2047309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047309 Fup 0.0308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047309 Vd NA 2.585 L/kg 1compartment NA NA Human Human +DTXSID2047309 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2047309 TK.Half.Life NA 26.58 hours 1compartment NA NA Human Human +DTXSID2047309 Css NA 1.368 mg/L 3compartmentss NA 50% Human Human +DTXSID2047309 Css NA 9.719 mg/L 3compartmentss NA 95% Human Human +DTXSID2047309 Css NA 0.9137 mg/L PBTK NA 50% Human Human +DTXSID2047309 Css NA 6.291 mg/L PBTK NA 95% Human Human +DTXSID2047309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047309 Fup 0.0308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047309 Vd NA 1.933 L/kg 1compartment NA NA Rat Human +DTXSID2047309 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2047309 TK.Half.Life NA 6.261 hours 1compartment NA NA Rat Human +DTXSID2047309 Css NA 0.1775 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047309 Css NA 1.055 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047309 Css NA 0.1163 mg/L PBTK NA 50% Rat Human +DTXSID2047309 Css NA 0.6713 mg/L PBTK NA 95% Rat Human +DTXSID2047351 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047351 Fup 0.0637 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047351 Vd NA 1.424 L/kg 1compartment NA NA Human Human DTXSID2047351 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047351 TK.Half.Life NA 2.612 hours 1compartment NA NA Human Human -DTXSID2047351 Css NA 0.007232 mg/L 3compartmentss NA 50% Human Human -DTXSID2047351 Css NA 0.05335 mg/L 3compartmentss NA 95% Human Human -DTXSID2047351 Css NA 0.005753 mg/L PBTK NA 50% Human Human -DTXSID2047351 Css NA 0.03851 mg/L PBTK NA 95% Human Human -DTXSID2047351 Clint NA 317.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047351 Fup NA 0.058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047351 Vd NA 2.874 L/kg 1compartment NA NA Rat Human +DTXSID2047351 TK.Half.Life NA 4.168 hours 1compartment NA NA Human Human +DTXSID2047351 Css NA 0.2862 mg/L 3compartmentss NA 50% Human Human +DTXSID2047351 Css NA 2.547 mg/L 3compartmentss NA 95% Human Human +DTXSID2047351 Css NA 0.204 mg/L PBTK NA 50% Human Human +DTXSID2047351 Css NA 1.652 mg/L PBTK NA 95% Human Human +DTXSID2047351 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047351 Fup 0.0637 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047351 Vd NA 1.403 L/kg 1compartment NA NA Rat Human DTXSID2047351 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047351 TK.Half.Life NA 0.915 hours 1compartment NA NA Rat Human -DTXSID2047351 Css NA 0.004025 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047351 Css NA 0.02301 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047351 Css NA 0.003092 mg/L PBTK NA 50% Rat Human -DTXSID2047351 Css NA 0.01654 mg/L PBTK NA 95% Rat Human +DTXSID2047351 TK.Half.Life NA 2.523 hours 1compartment NA NA Rat Human +DTXSID2047351 Css NA 0.01362 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047351 Css NA 0.1368 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047351 Css NA 0.009585 mg/L PBTK NA 50% Rat Human +DTXSID2047351 Css NA 0.08504 mg/L PBTK NA 95% Rat Human +DTXSID2047353 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047353 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047353 Vd NA 2.575 L/kg 1compartment NA NA Human Human +DTXSID2047353 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2047353 TK.Half.Life NA 14.48 hours 1compartment NA NA Human Human +DTXSID2047353 Css NA 0.6607 mg/L 3compartmentss NA 50% Human Human +DTXSID2047353 Css NA 4.224 mg/L 3compartmentss NA 95% Human Human +DTXSID2047353 Css NA 0.4488 mg/L PBTK NA 50% Human Human +DTXSID2047353 Css NA 2.793 mg/L PBTK NA 95% Human Human +DTXSID2047353 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047353 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047353 Vd NA 1.934 L/kg 1compartment NA NA Rat Human +DTXSID2047353 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047353 TK.Half.Life NA 3.562 hours 1compartment NA NA Rat Human +DTXSID2047353 Css NA 0.08477 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047353 Css NA 0.4397 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047353 Css NA 0.05728 mg/L PBTK NA 50% Rat Human +DTXSID2047353 Css NA 0.2881 mg/L PBTK NA 95% Rat Human DTXSID2047355 Clint 7.06 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2047355 Fup 0.0607 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2047355 Vd NA 1.007 L/kg 1compartment NA NA Human Human -DTXSID2047355 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047355 TK.Half.Life NA 9.396 hours 1compartment NA NA Human Human -DTXSID2047355 Css NA 1.049 mg/L 3compartmentss NA 50% Human Human -DTXSID2047355 Css NA 5.799 mg/L 3compartmentss NA 95% Human Human -DTXSID2047355 Css NA 0.6702 mg/L PBTK NA 50% Human Human -DTXSID2047355 Css NA 3.569 mg/L PBTK NA 95% Human Human +DTXSID2047355 Vd NA 2.672 L/kg 1compartment NA NA Human Human +DTXSID2047355 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID2047355 TK.Half.Life NA 54.15 hours 1compartment NA NA Human Human +DTXSID2047355 Css NA 2.314 mg/L 3compartmentss NA 50% Human Human +DTXSID2047355 Css NA 13.1 mg/L 3compartmentss NA 95% Human Human +DTXSID2047355 Css NA 1.602 mg/L PBTK NA 50% Human Human +DTXSID2047355 Css NA 8.702 mg/L PBTK NA 95% Human Human DTXSID2047355 Clint 7.06 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2047355 Fup 0.0607 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2047355 Vd NA 0.77 L/kg 1compartment NA NA Rat Human -DTXSID2047355 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047355 TK.Half.Life NA 4.077 hours 1compartment NA NA Rat Human -DTXSID2047355 Css NA 0.5542 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047355 Css NA 2.237 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047355 Css NA 0.3379 mg/L PBTK NA 50% Rat Human -DTXSID2047355 Css NA 1.303 mg/L PBTK NA 95% Rat Human +DTXSID2047355 Vd NA 2.003 L/kg 1compartment NA NA Rat Human +DTXSID2047355 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID2047355 TK.Half.Life NA 11.49 hours 1compartment NA NA Rat Human +DTXSID2047355 Css NA 0.2603 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047355 Css NA 1.117 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047355 Css NA 0.1788 mg/L PBTK NA 50% Rat Human +DTXSID2047355 Css NA 0.7415 mg/L PBTK NA 95% Rat Human DTXSID2047357 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID2047357 Fup 3.63e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID2047357 Vd NA 0.9022 L/kg 1compartment NA NA Human Human +DTXSID2047357 Vd NA 0.3058 L/kg 1compartment NA NA Human Human DTXSID2047357 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID2047357 TK.Half.Life NA 58390 hours 1compartment NA NA Human Human -DTXSID2047357 Css NA 4696 mg/L 3compartmentss NA 50% Human Human -DTXSID2047357 Css NA 13700 mg/L 3compartmentss NA 95% Human Human -DTXSID2047357 Css NA 2894 mg/L PBTK NA 50% Human Human -DTXSID2047357 Css NA 8018 mg/L PBTK NA 95% Human Human +DTXSID2047357 TK.Half.Life NA 19790 hours 1compartment NA NA Human Human +DTXSID2047357 Css NA 4007 mg/L 3compartmentss NA 50% Human Human +DTXSID2047357 Css NA 13240 mg/L 3compartmentss NA 95% Human Human +DTXSID2047357 Css NA 2390 mg/L PBTK NA 50% Human Human +DTXSID2047357 Css NA 7543 mg/L PBTK NA 95% Human Human DTXSID2047357 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID2047357 Fup 3.63e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID2047357 Vd NA 0.6562 L/kg 1compartment NA NA Rat Human -DTXSID2047357 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID2047357 TK.Half.Life NA 14470 hours 1compartment NA NA Rat Human -DTXSID2047357 Css NA 1771 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047357 Css NA 2378 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047357 Css NA 997.3 mg/L PBTK NA 50% Rat Human -DTXSID2047357 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID2047359 Clint NA 1.781 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047359 Fup NA 0.3158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047359 Vd NA 4.577 L/kg 1compartment NA NA Human Human -DTXSID2047359 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2047359 TK.Half.Life NA 20.35 hours 1compartment NA NA Human Human -DTXSID2047359 Css NA 0.2533 mg/L 3compartmentss NA 50% Human Human -DTXSID2047359 Css NA 1.728 mg/L 3compartmentss NA 95% Human Human -DTXSID2047359 Css NA 0.3641 mg/L PBTK NA 50% Human Human -DTXSID2047359 Css NA 1.699 mg/L PBTK NA 95% Human Human -DTXSID2047359 Clint NA 1.781 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047359 Fup NA 0.3158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047359 Vd NA 4.643 L/kg 1compartment NA NA Rat Human -DTXSID2047359 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2047359 TK.Half.Life NA 11.27 hours 1compartment NA NA Rat Human -DTXSID2047359 Css NA 0.1106 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047359 Css NA 0.6318 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047359 Css NA 0.1612 mg/L PBTK NA 50% Rat Human -DTXSID2047359 Css NA 0.5577 mg/L PBTK NA 95% Rat Human -DTXSID2047434 Clint NA 85.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047434 Fup NA 0.1188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047434 Vd NA 1.248 L/kg 1compartment NA NA Human Human +DTXSID2047357 Vd NA 0.2415 L/kg 1compartment NA NA Rat Human +DTXSID2047357 Days.Css NA 1472 Days PBTK NA NA Rat Human +DTXSID2047357 TK.Half.Life NA 5324 hours 1compartment NA NA Rat Human +DTXSID2047357 Css NA 358.3 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047357 Css NA 554.2 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047357 Css NA 201.4 mg/L PBTK NA 50% Rat Human +DTXSID2047357 Css NA 311.1 mg/L PBTK NA 95% Rat Human +DTXSID2047359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047359 Fup 0.199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047359 Vd NA 3.218 L/kg 1compartment NA NA Human Human +DTXSID2047359 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2047359 TK.Half.Life NA 3.652 hours 1compartment NA NA Human Human +DTXSID2047359 Css NA 0.05042 mg/L 3compartmentss NA 50% Human Human +DTXSID2047359 Css NA 0.4676 mg/L 3compartmentss NA 95% Human Human +DTXSID2047359 Css NA 0.05574 mg/L PBTK NA 50% Human Human +DTXSID2047359 Css NA 0.4119 mg/L PBTK NA 95% Human Human +DTXSID2047359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047359 Fup 0.199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047359 Vd NA 3.241 L/kg 1compartment NA NA Rat Human +DTXSID2047359 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047359 TK.Half.Life NA 2.092 hours 1compartment NA NA Rat Human +DTXSID2047359 Css NA 0.00623 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047359 Css NA 0.04099 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047359 Css NA 0.00713 mg/L PBTK NA 50% Rat Human +DTXSID2047359 Css NA 0.03773 mg/L PBTK NA 95% Rat Human +DTXSID2047434 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047434 Fup 0.433 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047434 Vd NA 0.5731 L/kg 1compartment NA NA Human Human DTXSID2047434 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047434 TK.Half.Life NA 1.56 hours 1compartment NA NA Human Human -DTXSID2047434 Css NA 0.06629 mg/L 3compartmentss NA 50% Human Human -DTXSID2047434 Css NA 0.5394 mg/L 3compartmentss NA 95% Human Human -DTXSID2047434 Css NA 0.0439 mg/L PBTK NA 50% Human Human -DTXSID2047434 Css NA 0.3345 mg/L PBTK NA 95% Human Human -DTXSID2047434 Clint NA 85.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047434 Fup NA 0.1188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047434 Vd NA 0.9646 L/kg 1compartment NA NA Rat Human +DTXSID2047434 TK.Half.Life NA 8.624 hours 1compartment NA NA Human Human +DTXSID2047434 Css NA 1.656 mg/L 3compartmentss NA 50% Human Human +DTXSID2047434 Css NA 7.271 mg/L 3compartmentss NA 95% Human Human +DTXSID2047434 Css NA 1.215 mg/L PBTK NA 50% Human Human +DTXSID2047434 Css NA 4.605 mg/L PBTK NA 95% Human Human +DTXSID2047434 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047434 Fup 0.433 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047434 Vd NA 0.5613 L/kg 1compartment NA NA Rat Human DTXSID2047434 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047434 TK.Half.Life NA 0.5854 hours 1compartment NA NA Rat Human -DTXSID2047434 Css NA 0.03712 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047434 Css NA 0.2446 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047434 Css NA 0.0232 mg/L PBTK NA 50% Rat Human -DTXSID2047434 Css NA 0.1454 mg/L PBTK NA 95% Rat Human -DTXSID2047436 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047436 Fup NA 0.1421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047436 Vd NA 0.3045 L/kg 1compartment NA NA Human Human +DTXSID2047434 TK.Half.Life NA 2.863 hours 1compartment NA NA Rat Human +DTXSID2047434 Css NA 0.1056 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047434 Css NA 0.413 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047434 Css NA 0.0766 mg/L PBTK NA 50% Rat Human +DTXSID2047434 Css NA 0.2518 mg/L PBTK NA 95% Rat Human +DTXSID2047436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047436 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047436 Vd NA 0.382 L/kg 1compartment NA NA Human Human DTXSID2047436 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2047436 TK.Half.Life NA 13.89 hours 1compartment NA NA Human Human -DTXSID2047436 Css NA 6.693 mg/L 3compartmentss NA 50% Human Human -DTXSID2047436 Css NA 30.73 mg/L 3compartmentss NA 95% Human Human -DTXSID2047436 Css NA 4.214 mg/L PBTK NA 50% Human Human -DTXSID2047436 Css NA 18.07 mg/L PBTK NA 95% Human Human -DTXSID2047436 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047436 Fup NA 0.1421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047436 Vd NA 0.2969 L/kg 1compartment NA NA Rat Human +DTXSID2047436 TK.Half.Life NA 10.28 hours 1compartment NA NA Human Human +DTXSID2047436 Css NA 1.73 mg/L 3compartmentss NA 50% Human Human +DTXSID2047436 Css NA 7.136 mg/L 3compartmentss NA 95% Human Human +DTXSID2047436 Css NA 1.163 mg/L PBTK NA 50% Human Human +DTXSID2047436 Css NA 4.381 mg/L PBTK NA 95% Human Human +DTXSID2047436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047436 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047436 Vd NA 0.3735 L/kg 1compartment NA NA Rat Human DTXSID2047436 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047436 TK.Half.Life NA 4.609 hours 1compartment NA NA Rat Human -DTXSID2047436 Css NA 1.886 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047436 Css NA 7.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047436 Css NA 1.108 mg/L PBTK NA 50% Rat Human -DTXSID2047436 Css NA 4.069 mg/L PBTK NA 95% Rat Human -DTXSID2047484 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047484 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047484 Vd NA 2.278 L/kg 1compartment NA NA Human Human -DTXSID2047484 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID2047484 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human -DTXSID2047484 Css NA 5.766 mg/L 3compartmentss NA 50% Human Human -DTXSID2047484 Css NA 18.35 mg/L 3compartmentss NA 95% Human Human -DTXSID2047484 Css NA 4.315 mg/L PBTK NA 50% Human Human -DTXSID2047484 Css NA 12.3 mg/L PBTK NA 95% Human Human -DTXSID2047484 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047484 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047484 Vd NA 1.758 L/kg 1compartment NA NA Rat Human -DTXSID2047484 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID2047484 TK.Half.Life NA 18.69 hours 1compartment NA NA Rat Human -DTXSID2047484 Css NA 1.568 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047484 Css NA 4.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047484 Css NA 1.13 mg/L PBTK NA 50% Rat Human -DTXSID2047484 Css NA 2.563 mg/L PBTK NA 95% Rat Human -DTXSID2047486 Clint NA 59.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047486 Fup NA 0.5223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047486 Vd NA 1.182 L/kg 1compartment NA NA Human Human -DTXSID2047486 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047486 TK.Half.Life NA 0.8939 hours 1compartment NA NA Human Human -DTXSID2047486 Css NA 0.01486 mg/L 3compartmentss NA 50% Human Human -DTXSID2047486 Css NA 0.145 mg/L 3compartmentss NA 95% Human Human -DTXSID2047486 Css NA 0.01225 mg/L PBTK NA 50% Human Human -DTXSID2047486 Css NA 0.1007 mg/L PBTK NA 95% Human Human -DTXSID2047486 Clint NA 59.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047486 Fup NA 0.5223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047486 Vd NA 1.048 L/kg 1compartment NA NA Rat Human -DTXSID2047486 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047486 TK.Half.Life NA 0.3662 hours 1compartment NA NA Rat Human -DTXSID2047486 Css NA 0.007798 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047486 Css NA 0.06363 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047486 Css NA 0.006246 mg/L PBTK NA 50% Rat Human -DTXSID2047486 Css NA 0.0439 mg/L PBTK NA 95% Rat Human -DTXSID2047511 Clint NA 7.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047511 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047511 Vd NA 46.73 L/kg 1compartment NA NA Human Human -DTXSID2047511 Days.Css NA 1112 Days PBTK NA NA Human Human -DTXSID2047511 TK.Half.Life NA 4138 hours 1compartment NA NA Human Human -DTXSID2047511 Css NA 1.424 mg/L 3compartmentss NA 50% Human Human -DTXSID2047511 Css NA 8.847 mg/L 3compartmentss NA 95% Human Human -DTXSID2047511 Css NA 7.25 mg/L PBTK NA 50% Human Human -DTXSID2047511 Css NA 41.62 mg/L PBTK NA 95% Human Human -DTXSID2047511 Clint NA 7.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047511 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047511 Vd NA 39.29 L/kg 1compartment NA NA Rat Human -DTXSID2047511 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID2047511 TK.Half.Life NA 608 hours 1compartment NA NA Rat Human -DTXSID2047511 Css NA 0.7371 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047511 Css NA 3.161 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047511 Css NA 3.984 mg/L PBTK NA 50% Rat Human -DTXSID2047511 Css NA 16.7 mg/L PBTK NA 95% Rat Human -DTXSID2047517 Clint NA 79.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047517 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047517 Vd NA 108.9 L/kg 1compartment NA NA Human Human -DTXSID2047517 Days.Css NA 210 Days PBTK NA NA Human Human -DTXSID2047517 TK.Half.Life NA 888 hours 1compartment NA NA Human Human -DTXSID2047517 Css NA 0.0513 mg/L 3compartmentss NA 50% Human Human -DTXSID2047517 Css NA 0.3052 mg/L 3compartmentss NA 95% Human Human -DTXSID2047517 Css NA 0.6774 mg/L PBTK NA 50% Human Human -DTXSID2047517 Css NA 3.639 mg/L PBTK NA 95% Human Human -DTXSID2047517 Clint NA 79.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047517 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047517 Vd NA 94.4 L/kg 1compartment NA NA Rat Human -DTXSID2047517 Days.Css NA 138 Days PBTK NA NA Rat Human -DTXSID2047517 TK.Half.Life NA 135.9 hours 1compartment NA NA Rat Human -DTXSID2047517 Css NA 0.02578 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047517 Css NA 0.1121 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047517 Css NA 0.3654 mg/L PBTK NA 50% Rat Human -DTXSID2047517 Css NA 1.654 mg/L PBTK NA 95% Rat Human -DTXSID2047569 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047569 Fup NA 0.0478 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047569 Vd NA 1.66 L/kg 1compartment NA NA Human Human -DTXSID2047569 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2047569 TK.Half.Life NA 16 hours 1compartment NA NA Human Human -DTXSID2047569 Css NA 1.452 mg/L 3compartmentss NA 50% Human Human -DTXSID2047569 Css NA 9.739 mg/L 3compartmentss NA 95% Human Human -DTXSID2047569 Css NA 0.934 mg/L PBTK NA 50% Human Human -DTXSID2047569 Css NA 6.111 mg/L PBTK NA 95% Human Human -DTXSID2047569 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047569 Fup NA 0.0478 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047569 Vd NA 1.244 L/kg 1compartment NA NA Rat Human +DTXSID2047436 TK.Half.Life NA 3.418 hours 1compartment NA NA Rat Human +DTXSID2047436 Css NA 0.009405 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047436 Css NA 0.0385 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047436 Css NA 0.005978 mg/L PBTK NA 50% Rat Human +DTXSID2047436 Css NA 0.02266 mg/L PBTK NA 95% Rat Human +DTXSID2047567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047567 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047567 Vd NA 2.662 L/kg 1compartment NA NA Human Human +DTXSID2047567 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2047567 TK.Half.Life NA 28.67 hours 1compartment NA NA Human Human +DTXSID2047567 Css NA 1.418 mg/L 3compartmentss NA 50% Human Human +DTXSID2047567 Css NA 10.45 mg/L 3compartmentss NA 95% Human Human +DTXSID2047567 Css NA 0.9558 mg/L PBTK NA 50% Human Human +DTXSID2047567 Css NA 6.781 mg/L PBTK NA 95% Human Human +DTXSID2047567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047567 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047567 Vd NA 1.991 L/kg 1compartment NA NA Rat Human +DTXSID2047567 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2047567 TK.Half.Life NA 6.394 hours 1compartment NA NA Rat Human +DTXSID2047567 Css NA 0.1841 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047567 Css NA 1.039 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047567 Css NA 0.1216 mg/L PBTK NA 50% Rat Human +DTXSID2047567 Css NA 0.6672 mg/L PBTK NA 95% Rat Human +DTXSID2047569 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047569 Fup 0.0457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047569 Vd NA 1.643 L/kg 1compartment NA NA Human Human +DTXSID2047569 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2047569 TK.Half.Life NA 8.517 hours 1compartment NA NA Human Human +DTXSID2047569 Css NA 0.6952 mg/L 3compartmentss NA 50% Human Human +DTXSID2047569 Css NA 5.473 mg/L 3compartmentss NA 95% Human Human +DTXSID2047569 Css NA 0.4445 mg/L PBTK NA 50% Human Human +DTXSID2047569 Css NA 3.376 mg/L PBTK NA 95% Human Human +DTXSID2047569 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047569 Fup 0.0457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047569 Vd NA 1.232 L/kg 1compartment NA NA Rat Human DTXSID2047569 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047569 TK.Half.Life NA 5.82 hours 1compartment NA NA Rat Human -DTXSID2047569 Css NA 0.7936 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047569 Css NA 4.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047569 Css NA 0.4814 mg/L PBTK NA 50% Rat Human -DTXSID2047569 Css NA 2.5 mg/L PBTK NA 95% Rat Human -DTXSID2047644 Clint NA 5.862 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047644 Fup NA 0.3029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047644 Vd NA 1.468 L/kg 1compartment NA NA Human Human -DTXSID2047644 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047644 TK.Half.Life NA 4.329 hours 1compartment NA NA Human Human -DTXSID2047644 Css NA 0.2677 mg/L 3compartmentss NA 50% Human Human -DTXSID2047644 Css NA 1.584 mg/L 3compartmentss NA 95% Human Human -DTXSID2047644 Css NA 0.2054 mg/L PBTK NA 50% Human Human -DTXSID2047644 Css NA 1.092 mg/L PBTK NA 95% Human Human -DTXSID2047644 Clint NA 5.862 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047644 Fup NA 0.3029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047644 Vd NA 1.194 L/kg 1compartment NA NA Rat Human -DTXSID2047644 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047644 TK.Half.Life NA 1.777 hours 1compartment NA NA Rat Human -DTXSID2047644 Css NA 0.1382 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047644 Css NA 0.6003 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047644 Css NA 0.1006 mg/L PBTK NA 50% Rat Human -DTXSID2047644 Css NA 0.3894 mg/L PBTK NA 95% Rat Human -DTXSID2047694 Clint NA 6.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047694 Fup NA 0.1956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047694 Vd NA 3.565 L/kg 1compartment NA NA Human Human +DTXSID2047569 TK.Half.Life NA 3.149 hours 1compartment NA NA Rat Human +DTXSID2047569 Css NA 0.09011 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047569 Css NA 0.5097 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047569 Css NA 0.05618 mg/L PBTK NA 50% Rat Human +DTXSID2047569 Css NA 0.312 mg/L PBTK NA 95% Rat Human +DTXSID2047646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047646 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047646 Vd NA 2.195 L/kg 1compartment NA NA Human Human +DTXSID2047646 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2047646 TK.Half.Life NA 16.49 hours 1compartment NA NA Human Human +DTXSID2047646 Css NA 1.008 mg/L 3compartmentss NA 50% Human Human +DTXSID2047646 Css NA 6.878 mg/L 3compartmentss NA 95% Human Human +DTXSID2047646 Css NA 0.6582 mg/L PBTK NA 50% Human Human +DTXSID2047646 Css NA 4.338 mg/L PBTK NA 95% Human Human +DTXSID2047646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047646 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047646 Vd NA 1.639 L/kg 1compartment NA NA Rat Human +DTXSID2047646 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047646 TK.Half.Life NA 4.899 hours 1compartment NA NA Rat Human +DTXSID2047646 Css NA 0.1296 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047646 Css NA 0.7018 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047646 Css NA 0.08382 mg/L PBTK NA 50% Rat Human +DTXSID2047646 Css NA 0.4436 mg/L PBTK NA 95% Rat Human +DTXSID2047648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047648 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047648 Vd NA 1.971 L/kg 1compartment NA NA Human Human +DTXSID2047648 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2047648 TK.Half.Life NA 4.79 hours 1compartment NA NA Human Human +DTXSID2047648 Css NA 0.2229 mg/L 3compartmentss NA 50% Human Human +DTXSID2047648 Css NA 1.556 mg/L 3compartmentss NA 95% Human Human +DTXSID2047648 Css NA 0.1558 mg/L PBTK NA 50% Human Human +DTXSID2047648 Css NA 1.033 mg/L PBTK NA 95% Human Human +DTXSID2047648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047648 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047648 Vd NA 1.51 L/kg 1compartment NA NA Rat Human +DTXSID2047648 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047648 TK.Half.Life NA 1.632 hours 1compartment NA NA Rat Human +DTXSID2047648 Css NA 0.02822 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047648 Css NA 0.1579 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047648 Css NA 0.01946 mg/L PBTK NA 50% Rat Human +DTXSID2047648 Css NA 0.1038 mg/L PBTK NA 95% Rat Human +DTXSID2047694 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047694 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047694 Vd NA 3.626 L/kg 1compartment NA NA Human Human DTXSID2047694 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047694 TK.Half.Life NA 12.31 hours 1compartment NA NA Human Human -DTXSID2047694 Css NA 0.2598 mg/L 3compartmentss NA 50% Human Human -DTXSID2047694 Css NA 1.623 mg/L 3compartmentss NA 95% Human Human -DTXSID2047694 Css NA 0.2613 mg/L PBTK NA 50% Human Human -DTXSID2047694 Css NA 1.412 mg/L PBTK NA 95% Human Human -DTXSID2047694 Clint NA 6.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047694 Fup NA 0.1956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047694 Vd NA 3.345 L/kg 1compartment NA NA Rat Human +DTXSID2047694 TK.Half.Life NA 10.23 hours 1compartment NA NA Human Human +DTXSID2047694 Css NA 0.1904 mg/L 3compartmentss NA 50% Human Human +DTXSID2047694 Css NA 1.277 mg/L 3compartmentss NA 95% Human Human +DTXSID2047694 Css NA 0.2036 mg/L PBTK NA 50% Human Human +DTXSID2047694 Css NA 1.138 mg/L PBTK NA 95% Human Human +DTXSID2047694 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047694 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047694 Vd NA 3.491 L/kg 1compartment NA NA Rat Human DTXSID2047694 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047694 TK.Half.Life NA 5.536 hours 1compartment NA NA Rat Human -DTXSID2047694 Css NA 0.1314 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047694 Css NA 0.625 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047694 Css NA 0.1323 mg/L PBTK NA 50% Rat Human -DTXSID2047694 Css NA 0.5196 mg/L PBTK NA 95% Rat Human -DTXSID2047696 Clint NA 7.646 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047696 Fup NA 0.553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047696 Vd NA 0.9842 L/kg 1compartment NA NA Human Human -DTXSID2047696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047696 TK.Half.Life NA 1.407 hours 1compartment NA NA Human Human -DTXSID2047696 Css NA 0.1014 mg/L 3compartmentss NA 50% Human Human -DTXSID2047696 Css NA 0.917 mg/L 3compartmentss NA 95% Human Human -DTXSID2047696 Css NA 0.0832 mg/L PBTK NA 50% Human Human -DTXSID2047696 Css NA 0.6265 mg/L PBTK NA 95% Human Human -DTXSID2047696 Clint NA 7.646 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047696 Fup NA 0.553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047696 Vd NA 0.9136 L/kg 1compartment NA NA Rat Human -DTXSID2047696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047696 TK.Half.Life NA 0.6953 hours 1compartment NA NA Rat Human -DTXSID2047696 Css NA 0.05014 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047696 Css NA 0.3995 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047696 Css NA 0.04003 mg/L PBTK NA 50% Rat Human -DTXSID2047696 Css NA 0.2467 mg/L PBTK NA 95% Rat Human -DTXSID2047721 Clint NA 10.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047721 Fup NA 0.1365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047721 Vd NA 2.822 L/kg 1compartment NA NA Human Human -DTXSID2047721 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2047721 TK.Half.Life NA 26.94 hours 1compartment NA NA Human Human -DTXSID2047721 Css NA 1.144 mg/L 3compartmentss NA 50% Human Human -DTXSID2047721 Css NA 6.929 mg/L 3compartmentss NA 95% Human Human -DTXSID2047721 Css NA 0.8006 mg/L PBTK NA 50% Human Human -DTXSID2047721 Css NA 4.668 mg/L PBTK NA 95% Human Human -DTXSID2047721 Clint NA 10.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047721 Fup NA 0.1365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047721 Vd NA 2.127 L/kg 1compartment NA NA Rat Human -DTXSID2047721 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2047721 TK.Half.Life NA 5.357 hours 1compartment NA NA Rat Human -DTXSID2047721 Css NA 0.6235 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047721 Css NA 2.767 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047721 Css NA 0.418 mg/L PBTK NA 50% Rat Human -DTXSID2047721 Css NA 1.791 mg/L PBTK NA 95% Rat Human -DTXSID2047725 Clint NA 23.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047725 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047725 Vd NA 2.439 L/kg 1compartment NA NA Human Human +DTXSID2047694 TK.Half.Life NA 5.03 hours 1compartment NA NA Rat Human +DTXSID2047694 Css NA 0.02197 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047694 Css NA 0.1084 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047694 Css NA 0.02441 mg/L PBTK NA 50% Rat Human +DTXSID2047694 Css NA 0.09458 mg/L PBTK NA 95% Rat Human +DTXSID2047725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047725 Fup 0.0141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047725 Vd NA 1.339 L/kg 1compartment NA NA Human Human DTXSID2047725 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2047725 TK.Half.Life NA 18.03 hours 1compartment NA NA Human Human -DTXSID2047725 Css NA 1.007 mg/L 3compartmentss NA 50% Human Human -DTXSID2047725 Css NA 7.398 mg/L 3compartmentss NA 95% Human Human -DTXSID2047725 Css NA 0.6672 mg/L PBTK NA 50% Human Human -DTXSID2047725 Css NA 4.672 mg/L PBTK NA 95% Human Human -DTXSID2047725 Clint NA 23.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047725 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047725 Vd NA 1.824 L/kg 1compartment NA NA Rat Human +DTXSID2047725 TK.Half.Life NA 15.65 hours 1compartment NA NA Human Human +DTXSID2047725 Css NA 1.886 mg/L 3compartmentss NA 50% Human Human +DTXSID2047725 Css NA 16.77 mg/L 3compartmentss NA 95% Human Human +DTXSID2047725 Css NA 1.163 mg/L PBTK NA 50% Human Human +DTXSID2047725 Css NA 9.932 mg/L PBTK NA 95% Human Human +DTXSID2047725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047725 Fup 0.0141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047725 Vd NA 0.9903 L/kg 1compartment NA NA Rat Human DTXSID2047725 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047725 TK.Half.Life NA 4.718 hours 1compartment NA NA Rat Human -DTXSID2047725 Css NA 0.5612 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047725 Css NA 3.311 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047725 Css NA 0.3545 mg/L PBTK NA 50% Rat Human -DTXSID2047725 Css NA 2.01 mg/L PBTK NA 95% Rat Human -DTXSID2047727 Clint NA 39.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047727 Fup NA 0.1312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047727 Vd NA 1.947 L/kg 1compartment NA NA Human Human +DTXSID2047725 TK.Half.Life NA 6.319 hours 1compartment NA NA Rat Human +DTXSID2047725 Css NA 0.2487 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047725 Css NA 1.853 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047725 Css NA 0.1486 mg/L PBTK NA 50% Rat Human +DTXSID2047725 Css NA 1.077 mg/L PBTK NA 95% Rat Human +DTXSID2047727 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047727 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047727 Vd NA 1.328 L/kg 1compartment NA NA Human Human DTXSID2047727 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047727 TK.Half.Life NA 3.599 hours 1compartment NA NA Human Human -DTXSID2047727 Css NA 0.1546 mg/L 3compartmentss NA 50% Human Human -DTXSID2047727 Css NA 1.118 mg/L 3compartmentss NA 95% Human Human -DTXSID2047727 Css NA 0.1063 mg/L PBTK NA 50% Human Human -DTXSID2047727 Css NA 0.7366 mg/L PBTK NA 95% Human Human -DTXSID2047727 Clint NA 39.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047727 Fup NA 0.1312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047727 Vd NA 1.485 L/kg 1compartment NA NA Rat Human +DTXSID2047727 TK.Half.Life NA 3.625 hours 1compartment NA NA Human Human +DTXSID2047727 Css NA 0.2951 mg/L 3compartmentss NA 50% Human Human +DTXSID2047727 Css NA 2.246 mg/L 3compartmentss NA 95% Human Human +DTXSID2047727 Css NA 0.1949 mg/L PBTK NA 50% Human Human +DTXSID2047727 Css NA 1.391 mg/L PBTK NA 95% Human Human +DTXSID2047727 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047727 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047727 Vd NA 1.024 L/kg 1compartment NA NA Rat Human DTXSID2047727 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047727 TK.Half.Life NA 1.229 hours 1compartment NA NA Rat Human -DTXSID2047727 Css NA 0.08564 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047727 Css NA 0.4894 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047727 Css NA 0.05608 mg/L PBTK NA 50% Rat Human -DTXSID2047727 Css NA 0.3064 mg/L PBTK NA 95% Rat Human -DTXSID2047773 Clint NA 4.496 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047773 Fup NA 0.1812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047773 Vd NA 3.665 L/kg 1compartment NA NA Human Human -DTXSID2047773 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2047773 TK.Half.Life NA 22.52 hours 1compartment NA NA Human Human -DTXSID2047773 Css NA 0.5429 mg/L 3compartmentss NA 50% Human Human -DTXSID2047773 Css NA 3.095 mg/L 3compartmentss NA 95% Human Human -DTXSID2047773 Css NA 0.5042 mg/L PBTK NA 50% Human Human -DTXSID2047773 Css NA 2.553 mg/L PBTK NA 95% Human Human -DTXSID2047773 Clint NA 4.496 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047773 Fup NA 0.1812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047773 Vd NA 3.245 L/kg 1compartment NA NA Rat Human -DTXSID2047773 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2047773 TK.Half.Life NA 7.355 hours 1compartment NA NA Rat Human -DTXSID2047773 Css NA 0.2783 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047773 Css NA 1.138 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047773 Css NA 0.2526 mg/L PBTK NA 50% Rat Human -DTXSID2047773 Css NA 0.908 mg/L PBTK NA 95% Rat Human -DTXSID2047775 Clint NA 4.105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047775 Fup NA 0.9974 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047775 Vd NA 3.519 L/kg 1compartment NA NA Human Human +DTXSID2047727 TK.Half.Life NA 1.468 hours 1compartment NA NA Rat Human +DTXSID2047727 Css NA 0.0383 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047727 Css NA 0.2287 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047727 Css NA 0.0246 mg/L PBTK NA 50% Rat Human +DTXSID2047727 Css NA 0.1386 mg/L PBTK NA 95% Rat Human +DTXSID2047773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047773 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047773 Vd NA 4.29 L/kg 1compartment NA NA Human Human +DTXSID2047773 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2047773 TK.Half.Life NA 4.892 hours 1compartment NA NA Human Human +DTXSID2047773 Css NA 0.05086 mg/L 3compartmentss NA 50% Human Human +DTXSID2047773 Css NA 0.4174 mg/L 3compartmentss NA 95% Human Human +DTXSID2047773 Css NA 0.05716 mg/L PBTK NA 50% Human Human +DTXSID2047773 Css NA 0.3977 mg/L PBTK NA 95% Human Human +DTXSID2047773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047773 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047773 Vd NA 4.027 L/kg 1compartment NA NA Rat Human +DTXSID2047773 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047773 TK.Half.Life NA 2.004 hours 1compartment NA NA Rat Human +DTXSID2047773 Css NA 0.006304 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047773 Css NA 0.03765 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047773 Css NA 0.007347 mg/L PBTK NA 50% Rat Human +DTXSID2047773 Css NA 0.03749 mg/L PBTK NA 95% Rat Human +DTXSID2047775 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047775 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047775 Vd NA 1.115 L/kg 1compartment NA NA Human Human DTXSID2047775 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047775 TK.Half.Life NA 3.859 hours 1compartment NA NA Human Human -DTXSID2047775 Css NA 0.07863 mg/L 3compartmentss NA 50% Human Human -DTXSID2047775 Css NA 0.7654 mg/L 3compartmentss NA 95% Human Human -DTXSID2047775 Css NA 0.09614 mg/L PBTK NA 50% Human Human -DTXSID2047775 Css NA 0.6555 mg/L PBTK NA 95% Human Human -DTXSID2047775 Clint NA 4.105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047775 Fup NA 0.9974 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047775 Vd NA 3.587 L/kg 1compartment NA NA Rat Human +DTXSID2047775 TK.Half.Life NA 2.413 hours 1compartment NA NA Human Human +DTXSID2047775 Css NA 0.1671 mg/L 3compartmentss NA 50% Human Human +DTXSID2047775 Css NA 1.153 mg/L 3compartmentss NA 95% Human Human +DTXSID2047775 Css NA 0.1336 mg/L PBTK NA 50% Human Human +DTXSID2047775 Css NA 0.8056 mg/L PBTK NA 95% Human Human +DTXSID2047775 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047775 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047775 Vd NA 1.124 L/kg 1compartment NA NA Rat Human DTXSID2047775 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047775 TK.Half.Life NA 2.16 hours 1compartment NA NA Rat Human -DTXSID2047775 Css NA 0.03421 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047775 Css NA 0.3089 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047775 Css NA 0.04335 mg/L PBTK NA 50% Rat Human -DTXSID2047775 Css NA 0.2309 mg/L PBTK NA 95% Rat Human -DTXSID2047777 Clint NA 9.471 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047777 Fup NA 0.1246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047777 Vd NA 3.051 L/kg 1compartment NA NA Human Human -DTXSID2047777 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID2047777 TK.Half.Life NA 63.71 hours 1compartment NA NA Human Human -DTXSID2047777 Css NA 2.503 mg/L 3compartmentss NA 50% Human Human -DTXSID2047777 Css NA 15.91 mg/L 3compartmentss NA 95% Human Human -DTXSID2047777 Css NA 1.764 mg/L PBTK NA 50% Human Human -DTXSID2047777 Css NA 10.7 mg/L PBTK NA 95% Human Human -DTXSID2047777 Clint NA 9.471 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047777 Fup NA 0.1246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047777 Vd NA 2.299 L/kg 1compartment NA NA Rat Human -DTXSID2047777 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID2047777 TK.Half.Life NA 9.764 hours 1compartment NA NA Rat Human -DTXSID2047777 Css NA 1.395 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047777 Css NA 6.206 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047777 Css NA 0.9344 mg/L PBTK NA 50% Rat Human -DTXSID2047777 Css NA 4.101 mg/L PBTK NA 95% Rat Human -DTXSID2047779 Clint NA 29.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047779 Fup NA 0.0196 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047779 Vd NA 2.8 L/kg 1compartment NA NA Human Human -DTXSID2047779 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2047779 TK.Half.Life NA 32.56 hours 1compartment NA NA Human Human -DTXSID2047779 Css NA 1.533 mg/L 3compartmentss NA 50% Human Human -DTXSID2047779 Css NA 10.25 mg/L 3compartmentss NA 95% Human Human -DTXSID2047779 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID2047779 Css NA 6.644 mg/L PBTK NA 95% Human Human -DTXSID2047779 Clint NA 29.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047779 Fup NA 0.0196 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047779 Vd NA 2.095 L/kg 1compartment NA NA Rat Human -DTXSID2047779 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2047779 TK.Half.Life NA 6.484 hours 1compartment NA NA Rat Human -DTXSID2047779 Css NA 0.8531 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047779 Css NA 4.732 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047779 Css NA 0.5494 mg/L PBTK NA 50% Rat Human -DTXSID2047779 Css NA 2.912 mg/L PBTK NA 95% Rat Human -DTXSID2047800 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047800 Fup NA 0.5053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047800 Vd NA 0.9355 L/kg 1compartment NA NA Human Human -DTXSID2047800 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2047800 TK.Half.Life NA 11.98 hours 1compartment NA NA Human Human -DTXSID2047800 Css NA 1.358 mg/L 3compartmentss NA 50% Human Human -DTXSID2047800 Css NA 7.463 mg/L 3compartmentss NA 95% Human Human -DTXSID2047800 Css NA 1.108 mg/L PBTK NA 50% Human Human -DTXSID2047800 Css NA 4.888 mg/L PBTK NA 95% Human Human -DTXSID2047800 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047800 Fup NA 0.5053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047800 Vd NA 0.9731 L/kg 1compartment NA NA Rat Human -DTXSID2047800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047800 TK.Half.Life NA 4.245 hours 1compartment NA NA Rat Human -DTXSID2047800 Css NA 0.3585 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047800 Css NA 1.781 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047800 Css NA 0.2842 mg/L PBTK NA 50% Rat Human -DTXSID2047800 Css NA 1.08 mg/L PBTK NA 95% Rat Human -DTXSID2047804 Clint NA 0.4073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047804 Fup NA 0.1264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047804 Vd NA 0.3001 L/kg 1compartment NA NA Human Human +DTXSID2047775 TK.Half.Life NA 1.387 hours 1compartment NA NA Rat Human +DTXSID2047775 Css NA 0.01955 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047775 Css NA 0.0974 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047775 Css NA 0.01573 mg/L PBTK NA 50% Rat Human +DTXSID2047775 Css NA 0.06645 mg/L PBTK NA 95% Rat Human +DTXSID2047777 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047777 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047777 Vd NA 3.076 L/kg 1compartment NA NA Human Human +DTXSID2047777 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2047777 TK.Half.Life NA 18.08 hours 1compartment NA NA Human Human +DTXSID2047777 Css NA 0.5976 mg/L 3compartmentss NA 50% Human Human +DTXSID2047777 Css NA 3.775 mg/L 3compartmentss NA 95% Human Human +DTXSID2047777 Css NA 0.4289 mg/L PBTK NA 50% Human Human +DTXSID2047777 Css NA 2.614 mg/L PBTK NA 95% Human Human +DTXSID2047777 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047777 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047777 Vd NA 2.332 L/kg 1compartment NA NA Rat Human +DTXSID2047777 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047777 TK.Half.Life NA 3.144 hours 1compartment NA NA Rat Human +DTXSID2047777 Css NA 0.07566 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047777 Css NA 0.3807 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047777 Css NA 0.05414 mg/L PBTK NA 50% Rat Human +DTXSID2047777 Css NA 0.2634 mg/L PBTK NA 95% Rat Human +DTXSID2047779 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047779 Fup 0.0555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047779 Vd NA 2.973 L/kg 1compartment NA NA Human Human +DTXSID2047779 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID2047779 TK.Half.Life NA 119.3 hours 1compartment NA NA Human Human +DTXSID2047779 Css NA 5.004 mg/L 3compartmentss NA 50% Human Human +DTXSID2047779 Css NA 29.13 mg/L 3compartmentss NA 95% Human Human +DTXSID2047779 Css NA 3.453 mg/L PBTK NA 50% Human Human +DTXSID2047779 Css NA 19.74 mg/L PBTK NA 95% Human Human +DTXSID2047779 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047779 Fup 0.0555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047779 Vd NA 2.23 L/kg 1compartment NA NA Rat Human +DTXSID2047779 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID2047779 TK.Half.Life NA 18.93 hours 1compartment NA NA Rat Human +DTXSID2047779 Css NA 0.6244 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047779 Css NA 3.009 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047779 Css NA 0.4284 mg/L PBTK NA 50% Rat Human +DTXSID2047779 Css NA 1.965 mg/L PBTK NA 95% Rat Human +DTXSID2047804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047804 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047804 Vd NA 0.4496 L/kg 1compartment NA NA Human Human DTXSID2047804 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047804 TK.Half.Life NA 9.221 hours 1compartment NA NA Human Human -DTXSID2047804 Css NA 4.542 mg/L 3compartmentss NA 50% Human Human -DTXSID2047804 Css NA 21.97 mg/L 3compartmentss NA 95% Human Human -DTXSID2047804 Css NA 2.833 mg/L PBTK NA 50% Human Human -DTXSID2047804 Css NA 13.06 mg/L PBTK NA 95% Human Human -DTXSID2047804 Clint NA 0.4073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047804 Fup NA 0.1264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047804 Vd NA 0.2918 L/kg 1compartment NA NA Rat Human +DTXSID2047804 TK.Half.Life NA 0.9723 hours 1compartment NA NA Human Human +DTXSID2047804 Css NA 0.1791 mg/L 3compartmentss NA 50% Human Human +DTXSID2047804 Css NA 1.549 mg/L 3compartmentss NA 95% Human Human +DTXSID2047804 Css NA 0.1155 mg/L PBTK NA 50% Human Human +DTXSID2047804 Css NA 0.9533 mg/L PBTK NA 95% Human Human +DTXSID2047804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047804 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047804 Vd NA 0.4065 L/kg 1compartment NA NA Rat Human DTXSID2047804 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047804 TK.Half.Life NA 3.842 hours 1compartment NA NA Rat Human -DTXSID2047804 Css NA 1.66 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047804 Css NA 6.702 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047804 Css NA 0.9704 mg/L PBTK NA 50% Rat Human -DTXSID2047804 Css NA 3.7 mg/L PBTK NA 95% Rat Human -DTXSID2047850 Clint NA 30.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047850 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047850 Vd NA 1.559 L/kg 1compartment NA NA Human Human +DTXSID2047804 TK.Half.Life NA 0.5071 hours 1compartment NA NA Rat Human +DTXSID2047804 Css NA 0.008685 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047804 Css NA 0.07983 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047804 Css NA 0.00541 mg/L PBTK NA 50% Rat Human +DTXSID2047804 Css NA 0.04735 mg/L PBTK NA 95% Rat Human +DTXSID2047806 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047806 Fup 0.775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047806 Vd NA 1.654 L/kg 1compartment NA NA Human Human +DTXSID2047806 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2047806 TK.Half.Life NA 13.81 hours 1compartment NA NA Human Human +DTXSID2047806 Css NA 0.7481 mg/L 3compartmentss NA 50% Human Human +DTXSID2047806 Css NA 5.316 mg/L 3compartmentss NA 95% Human Human +DTXSID2047806 Css NA 0.7218 mg/L PBTK NA 50% Human Human +DTXSID2047806 Css NA 3.562 mg/L PBTK NA 95% Human Human +DTXSID2047806 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047806 Fup 0.775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047806 Vd NA 1.684 L/kg 1compartment NA NA Rat Human +DTXSID2047806 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2047806 TK.Half.Life NA 4.79 hours 1compartment NA NA Rat Human +DTXSID2047806 Css NA 0.01928 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047806 Css NA 0.1536 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047806 Css NA 0.01814 mg/L PBTK NA 50% Rat Human +DTXSID2047806 Css NA 0.1058 mg/L PBTK NA 95% Rat Human +DTXSID2047850 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047850 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047850 Vd NA 2.318 L/kg 1compartment NA NA Human Human DTXSID2047850 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047850 TK.Half.Life NA 3.156 hours 1compartment NA NA Human Human -DTXSID2047850 Css NA 0.1924 mg/L 3compartmentss NA 50% Human Human -DTXSID2047850 Css NA 1.695 mg/L 3compartmentss NA 95% Human Human -DTXSID2047850 Css NA 0.1414 mg/L PBTK NA 50% Human Human -DTXSID2047850 Css NA 1.107 mg/L PBTK NA 95% Human Human -DTXSID2047850 Clint NA 30.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047850 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047850 Vd NA 1.539 L/kg 1compartment NA NA Rat Human +DTXSID2047850 TK.Half.Life NA 3.614 hours 1compartment NA NA Human Human +DTXSID2047850 Css NA 0.1067 mg/L 3compartmentss NA 50% Human Human +DTXSID2047850 Css NA 0.9701 mg/L 3compartmentss NA 95% Human Human +DTXSID2047850 Css NA 0.09342 mg/L PBTK NA 50% Human Human +DTXSID2047850 Css NA 0.7025 mg/L PBTK NA 95% Human Human +DTXSID2047850 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047850 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047850 Vd NA 2.318 L/kg 1compartment NA NA Rat Human DTXSID2047850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047850 TK.Half.Life NA 1.842 hours 1compartment NA NA Rat Human -DTXSID2047850 Css NA 0.1089 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047850 Css NA 0.767 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047850 Css NA 0.07614 mg/L PBTK NA 50% Rat Human -DTXSID2047850 Css NA 0.4791 mg/L PBTK NA 95% Rat Human -DTXSID2047852 Clint NA 48.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047852 Fup NA 0.0894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047852 Vd NA 2.505 L/kg 1compartment NA NA Human Human +DTXSID2047850 TK.Half.Life NA 2.088 hours 1compartment NA NA Rat Human +DTXSID2047850 Css NA 0.01324 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047850 Css NA 0.0976 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047850 Css NA 0.01177 mg/L PBTK NA 50% Rat Human +DTXSID2047850 Css NA 0.0704 mg/L PBTK NA 95% Rat Human +DTXSID2047852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047852 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047852 Vd NA 0.4155 L/kg 1compartment NA NA Human Human DTXSID2047852 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047852 TK.Half.Life NA 6.551 hours 1compartment NA NA Human Human -DTXSID2047852 Css NA 0.255 mg/L 3compartmentss NA 50% Human Human -DTXSID2047852 Css NA 1.742 mg/L 3compartmentss NA 95% Human Human -DTXSID2047852 Css NA 0.1752 mg/L PBTK NA 50% Human Human -DTXSID2047852 Css NA 1.146 mg/L PBTK NA 95% Human Human -DTXSID2047852 Clint NA 48.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047852 Fup NA 0.0894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047852 Vd NA 1.887 L/kg 1compartment NA NA Rat Human +DTXSID2047852 TK.Half.Life NA 0.6776 hours 1compartment NA NA Human Human +DTXSID2047852 Css NA 0.1039 mg/L 3compartmentss NA 50% Human Human +DTXSID2047852 Css NA 0.78 mg/L 3compartmentss NA 95% Human Human +DTXSID2047852 Css NA 0.06887 mg/L PBTK NA 50% Human Human +DTXSID2047852 Css NA 0.4907 mg/L PBTK NA 95% Human Human +DTXSID2047852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047852 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047852 Vd NA 0.4115 L/kg 1compartment NA NA Rat Human DTXSID2047852 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047852 TK.Half.Life NA 1.792 hours 1compartment NA NA Rat Human -DTXSID2047852 Css NA 0.1434 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047852 Css NA 0.8142 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047852 Css NA 0.09363 mg/L PBTK NA 50% Rat Human -DTXSID2047852 Css NA 0.5119 mg/L PBTK NA 95% Rat Human -DTXSID2047856 Clint NA 12.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047856 Fup NA 0.107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047856 Vd NA 3.467 L/kg 1compartment NA NA Human Human +DTXSID2047852 TK.Half.Life NA 0.3693 hours 1compartment NA NA Rat Human +DTXSID2047852 Css NA 0.01342 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047852 Css NA 0.07148 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047852 Css NA 0.008704 mg/L PBTK NA 50% Rat Human +DTXSID2047852 Css NA 0.04342 mg/L PBTK NA 95% Rat Human +DTXSID2047856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047856 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047856 Vd NA 3.519 L/kg 1compartment NA NA Human Human DTXSID2047856 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047856 TK.Half.Life NA 6.022 hours 1compartment NA NA Human Human -DTXSID2047856 Css NA 0.1303 mg/L 3compartmentss NA 50% Human Human -DTXSID2047856 Css NA 1.226 mg/L 3compartmentss NA 95% Human Human -DTXSID2047856 Css NA 0.1303 mg/L PBTK NA 50% Human Human -DTXSID2047856 Css NA 0.9904 mg/L PBTK NA 95% Human Human -DTXSID2047856 Clint NA 12.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047856 Fup NA 0.107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047856 Vd NA 3.385 L/kg 1compartment NA NA Rat Human +DTXSID2047856 TK.Half.Life NA 4.287 hours 1compartment NA NA Human Human +DTXSID2047856 Css NA 0.07062 mg/L 3compartmentss NA 50% Human Human +DTXSID2047856 Css NA 0.7108 mg/L 3compartmentss NA 95% Human Human +DTXSID2047856 Css NA 0.07155 mg/L PBTK NA 50% Human Human +DTXSID2047856 Css NA 0.5649 mg/L PBTK NA 95% Human Human +DTXSID2047856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047856 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047856 Vd NA 3.443 L/kg 1compartment NA NA Rat Human DTXSID2047856 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047856 TK.Half.Life NA 3.257 hours 1compartment NA NA Rat Human -DTXSID2047856 Css NA 0.07137 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047856 Css NA 0.5483 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047856 Css NA 0.06987 mg/L PBTK NA 50% Rat Human -DTXSID2047856 Css NA 0.4118 mg/L PBTK NA 95% Rat Human -DTXSID2047858 Clint NA 1041 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047858 Fup NA 0.0828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047858 Vd NA 2.464 L/kg 1compartment NA NA Human Human +DTXSID2047856 TK.Half.Life NA 2.256 hours 1compartment NA NA Rat Human +DTXSID2047856 Css NA 0.008964 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047856 Css NA 0.07546 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047856 Css NA 0.009221 mg/L PBTK NA 50% Rat Human +DTXSID2047856 Css NA 0.05855 mg/L PBTK NA 95% Rat Human +DTXSID2047858 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047858 Fup 0.0357 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2047858 Vd NA 1.642 L/kg 1compartment NA NA Human Human DTXSID2047858 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047858 TK.Half.Life NA 1.642 hours 1compartment NA NA Human Human -DTXSID2047858 Css NA 0.003828 mg/L 3compartmentss NA 50% Human Human -DTXSID2047858 Css NA 0.03626 mg/L 3compartmentss NA 95% Human Human -DTXSID2047858 Css NA 0.00315 mg/L PBTK NA 50% Human Human -DTXSID2047858 Css NA 0.02584 mg/L PBTK NA 95% Human Human -DTXSID2047858 Clint NA 1041 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047858 Fup NA 0.0828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047858 Vd NA 2.375 L/kg 1compartment NA NA Rat Human +DTXSID2047858 TK.Half.Life NA 5.686 hours 1compartment NA NA Human Human +DTXSID2047858 Css NA 0.4306 mg/L 3compartmentss NA 50% Human Human +DTXSID2047858 Css NA 3.559 mg/L 3compartmentss NA 95% Human Human +DTXSID2047858 Css NA 0.3 mg/L PBTK NA 50% Human Human +DTXSID2047858 Css NA 2.278 mg/L PBTK NA 95% Human Human +DTXSID2047858 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047858 Fup 0.0357 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2047858 Vd NA 1.539 L/kg 1compartment NA NA Rat Human DTXSID2047858 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047858 TK.Half.Life NA 0.7069 hours 1compartment NA NA Rat Human -DTXSID2047858 Css NA 0.002152 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047858 Css NA 0.01701 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047858 Css NA 0.001714 mg/L PBTK NA 50% Rat Human -DTXSID2047858 Css NA 0.01154 mg/L PBTK NA 95% Rat Human -DTXSID2047939 Clint NA 0.1658 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047939 Fup NA 0.8307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2047939 Vd NA 0.6341 L/kg 1compartment NA NA Human Human -DTXSID2047939 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2047939 TK.Half.Life NA 3.872 hours 1compartment NA NA Human Human -DTXSID2047939 Css NA 0.7584 mg/L 3compartmentss NA 50% Human Human -DTXSID2047939 Css NA 4.507 mg/L 3compartmentss NA 95% Human Human -DTXSID2047939 Css NA 0.6068 mg/L PBTK NA 50% Human Human -DTXSID2047939 Css NA 2.865 mg/L PBTK NA 95% Human Human -DTXSID2047939 Clint NA 0.1658 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047939 Fup NA 0.8307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2047939 Vd NA 0.6773 L/kg 1compartment NA NA Rat Human -DTXSID2047939 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2047939 TK.Half.Life NA 1.584 hours 1compartment NA NA Rat Human -DTXSID2047939 Css NA 0.2224 mg/L 3compartmentss NA 50% Rat Human -DTXSID2047939 Css NA 1.335 mg/L 3compartmentss NA 95% Rat Human -DTXSID2047939 Css NA 0.1727 mg/L PBTK NA 50% Rat Human -DTXSID2047939 Css NA 0.7889 mg/L PBTK NA 95% Rat Human -DTXSID2048161 Clint NA 38.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048161 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048161 Vd NA 2.309 L/kg 1compartment NA NA Human Human +DTXSID2047858 TK.Half.Life NA 3.211 hours 1compartment NA NA Rat Human +DTXSID2047858 Css NA 0.05672 mg/L 3compartmentss NA 50% Rat Human +DTXSID2047858 Css NA 0.3719 mg/L 3compartmentss NA 95% Rat Human +DTXSID2047858 Css NA 0.03896 mg/L PBTK NA 50% Rat Human +DTXSID2047858 Css NA 0.237 mg/L PBTK NA 95% Rat Human +DTXSID2048161 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048161 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048161 Vd NA 1.771 L/kg 1compartment NA NA Human Human DTXSID2048161 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048161 TK.Half.Life NA 2.894 hours 1compartment NA NA Human Human -DTXSID2048161 Css NA 0.08313 mg/L 3compartmentss NA 50% Human Human -DTXSID2048161 Css NA 0.8085 mg/L 3compartmentss NA 95% Human Human -DTXSID2048161 Css NA 0.07104 mg/L PBTK NA 50% Human Human -DTXSID2048161 Css NA 0.582 mg/L PBTK NA 95% Human Human -DTXSID2048161 Clint NA 38.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048161 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048161 Vd NA 2.281 L/kg 1compartment NA NA Rat Human +DTXSID2048161 TK.Half.Life NA 2.191 hours 1compartment NA NA Human Human +DTXSID2048161 Css NA 0.0621 mg/L 3compartmentss NA 50% Human Human +DTXSID2048161 Css NA 0.4673 mg/L 3compartmentss NA 95% Human Human +DTXSID2048161 Css NA 0.05272 mg/L PBTK NA 50% Human Human +DTXSID2048161 Css NA 0.3477 mg/L PBTK NA 95% Human Human +DTXSID2048161 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048161 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048161 Vd NA 1.759 L/kg 1compartment NA NA Rat Human DTXSID2048161 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048161 TK.Half.Life NA 1.597 hours 1compartment NA NA Rat Human -DTXSID2048161 Css NA 0.04637 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048161 Css NA 0.3633 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048161 Css NA 0.03802 mg/L PBTK NA 50% Rat Human -DTXSID2048161 Css NA 0.2494 mg/L PBTK NA 95% Rat Human -DTXSID2048169 Clint NA 5.077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048169 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048169 Vd NA 1.794 L/kg 1compartment NA NA Human Human -DTXSID2048169 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID2048169 TK.Half.Life NA 27.11 hours 1compartment NA NA Human Human -DTXSID2048169 Css NA 2.261 mg/L 3compartmentss NA 50% Human Human -DTXSID2048169 Css NA 13.41 mg/L 3compartmentss NA 95% Human Human -DTXSID2048169 Css NA 1.486 mg/L PBTK NA 50% Human Human -DTXSID2048169 Css NA 8.309 mg/L PBTK NA 95% Human Human -DTXSID2048169 Clint NA 5.077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048169 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048169 Vd NA 1.365 L/kg 1compartment NA NA Rat Human -DTXSID2048169 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2048169 TK.Half.Life NA 9.405 hours 1compartment NA NA Rat Human -DTXSID2048169 Css NA 1.192 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048169 Css NA 5.217 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048169 Css NA 0.7364 mg/L PBTK NA 50% Rat Human -DTXSID2048169 Css NA 3.016 mg/L PBTK NA 95% Rat Human -DTXSID2048379 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048379 Fup NA 0.1181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048379 Vd NA 1.961 L/kg 1compartment NA NA Human Human +DTXSID2048161 TK.Half.Life NA 1.188 hours 1compartment NA NA Rat Human +DTXSID2048161 Css NA 0.0077 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048161 Css NA 0.04575 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048161 Css NA 0.006645 mg/L PBTK NA 50% Rat Human +DTXSID2048161 Css NA 0.03433 mg/L PBTK NA 95% Rat Human +DTXSID2048169 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048169 Fup 0.0995 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048169 Vd NA 2.152 L/kg 1compartment NA NA Human Human +DTXSID2048169 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048169 TK.Half.Life NA 7.58 hours 1compartment NA NA Human Human +DTXSID2048169 Css NA 0.3885 mg/L 3compartmentss NA 50% Human Human +DTXSID2048169 Css NA 2.741 mg/L 3compartmentss NA 95% Human Human +DTXSID2048169 Css NA 0.2633 mg/L PBTK NA 50% Human Human +DTXSID2048169 Css NA 1.78 mg/L PBTK NA 95% Human Human +DTXSID2048169 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048169 Fup 0.0995 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048169 Vd NA 1.634 L/kg 1compartment NA NA Rat Human +DTXSID2048169 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048169 TK.Half.Life NA 2.398 hours 1compartment NA NA Rat Human +DTXSID2048169 Css NA 0.04946 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048169 Css NA 0.2774 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048169 Css NA 0.03324 mg/L PBTK NA 50% Rat Human +DTXSID2048169 Css NA 0.1805 mg/L PBTK NA 95% Rat Human +DTXSID2048240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048240 Fup 0.28 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2048240 Vd NA 3.229 L/kg 1compartment NA NA Human Human +DTXSID2048240 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048240 TK.Half.Life NA 14.29 hours 1compartment NA NA Human Human +DTXSID2048240 Css NA 0.4071 mg/L 3compartmentss NA 50% Human Human +DTXSID2048240 Css NA 2.645 mg/L 3compartmentss NA 95% Human Human +DTXSID2048240 Css NA 0.3088 mg/L PBTK NA 50% Human Human +DTXSID2048240 Css NA 1.915 mg/L PBTK NA 95% Human Human +DTXSID2048240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048240 Fup 0.28 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2048240 Vd NA 2.525 L/kg 1compartment NA NA Rat Human +DTXSID2048240 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048240 TK.Half.Life NA 2.811 hours 1compartment NA NA Rat Human +DTXSID2048240 Css NA 0.05208 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048240 Css NA 0.2643 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048240 Css NA 0.03946 mg/L PBTK NA 50% Rat Human +DTXSID2048240 Css NA 0.1873 mg/L PBTK NA 95% Rat Human +DTXSID2048244 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048244 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2048244 Vd NA 1.191 L/kg 1compartment NA NA Human Human +DTXSID2048244 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048244 TK.Half.Life NA 9.058 hours 1compartment NA NA Human Human +DTXSID2048244 Css NA 0.4614 mg/L 3compartmentss NA 50% Human Human +DTXSID2048244 Css NA 1.866 mg/L 3compartmentss NA 95% Human Human +DTXSID2048244 Css NA 0.412 mg/L PBTK NA 50% Human Human +DTXSID2048244 Css NA 1.383 mg/L PBTK NA 95% Human Human +DTXSID2048244 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048244 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2048244 Vd NA 1.115 L/kg 1compartment NA NA Rat Human +DTXSID2048244 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048244 TK.Half.Life NA 2.769 hours 1compartment NA NA Rat Human +DTXSID2048244 Css NA 0.00234 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048244 Css NA 0.01069 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048244 Css NA 0.002052 mg/L PBTK NA 50% Rat Human +DTXSID2048244 Css NA 0.007485 mg/L PBTK NA 95% Rat Human +DTXSID2048290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048290 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2048290 Vd NA 1.594 L/kg 1compartment NA NA Human Human +DTXSID2048290 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048290 TK.Half.Life NA 5.81 hours 1compartment NA NA Human Human +DTXSID2048290 Css NA 0.4564 mg/L 3compartmentss NA 50% Human Human +DTXSID2048290 Css NA 4.878 mg/L 3compartmentss NA 95% Human Human +DTXSID2048290 Css NA 0.3124 mg/L PBTK NA 50% Human Human +DTXSID2048290 Css NA 3.007 mg/L PBTK NA 95% Human Human +DTXSID2048290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048290 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2048290 Vd NA 1.44 L/kg 1compartment NA NA Rat Human +DTXSID2048290 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048290 TK.Half.Life NA 3.11 hours 1compartment NA NA Rat Human +DTXSID2048290 Css NA 0.059 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048290 Css NA 0.5464 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048290 Css NA 0.03957 mg/L PBTK NA 50% Rat Human +DTXSID2048290 Css NA 0.328 mg/L PBTK NA 95% Rat Human +DTXSID2048321 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048321 Fup 0.82 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2048321 Vd NA 2.941 L/kg 1compartment NA NA Human Human +DTXSID2048321 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048321 TK.Half.Life NA 10.55 hours 1compartment NA NA Human Human +DTXSID2048321 Css NA 0.3332 mg/L 3compartmentss NA 50% Human Human +DTXSID2048321 Css NA 1.935 mg/L 3compartmentss NA 95% Human Human +DTXSID2048321 Css NA 0.266 mg/L PBTK NA 50% Human Human +DTXSID2048321 Css NA 1.443 mg/L PBTK NA 95% Human Human +DTXSID2048321 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048321 Fup 0.82 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2048321 Vd NA 2.168 L/kg 1compartment NA NA Rat Human +DTXSID2048321 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048321 TK.Half.Life NA 2.454 hours 1compartment NA NA Rat Human +DTXSID2048321 Css NA 0.04269 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048321 Css NA 0.1907 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048321 Css NA 0.0336 mg/L PBTK NA 50% Rat Human +DTXSID2048321 Css NA 0.1343 mg/L PBTK NA 95% Rat Human +DTXSID2048329 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048329 Fup 0.19 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2048329 Vd NA 0.2615 L/kg 1compartment NA NA Human Human +DTXSID2048329 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048329 TK.Half.Life NA 8.902 hours 1compartment NA NA Human Human +DTXSID2048329 Css NA 2.361 mg/L 3compartmentss NA 50% Human Human +DTXSID2048329 Css NA 8.91 mg/L 3compartmentss NA 95% Human Human +DTXSID2048329 Css NA 1.499 mg/L PBTK NA 50% Human Human +DTXSID2048329 Css NA 5.305 mg/L PBTK NA 95% Human Human +DTXSID2048329 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048329 Fup 0.19 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2048329 Vd NA 0.2687 L/kg 1compartment NA NA Rat Human +DTXSID2048329 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048329 TK.Half.Life NA 3.118 hours 1compartment NA NA Rat Human +DTXSID2048329 Css NA 0.01264 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048329 Css NA 0.05048 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048329 Css NA 0.007536 mg/L PBTK NA 50% Rat Human +DTXSID2048329 Css NA 0.02876 mg/L PBTK NA 95% Rat Human +DTXSID2048379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048379 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048379 Vd NA 1.827 L/kg 1compartment NA NA Human Human DTXSID2048379 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048379 TK.Half.Life NA 6.876 hours 1compartment NA NA Human Human -DTXSID2048379 Css NA 0.3999 mg/L 3compartmentss NA 50% Human Human -DTXSID2048379 Css NA 2.896 mg/L 3compartmentss NA 95% Human Human -DTXSID2048379 Css NA 0.284 mg/L PBTK NA 50% Human Human -DTXSID2048379 Css NA 1.869 mg/L PBTK NA 95% Human Human -DTXSID2048379 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048379 Fup NA 0.1181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048379 Vd NA 1.586 L/kg 1compartment NA NA Rat Human +DTXSID2048379 TK.Half.Life NA 4.126 hours 1compartment NA NA Human Human +DTXSID2048379 Css NA 0.2052 mg/L 3compartmentss NA 50% Human Human +DTXSID2048379 Css NA 1.662 mg/L 3compartmentss NA 95% Human Human +DTXSID2048379 Css NA 0.1461 mg/L PBTK NA 50% Human Human +DTXSID2048379 Css NA 1.086 mg/L PBTK NA 95% Human Human +DTXSID2048379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048379 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048379 Vd NA 1.508 L/kg 1compartment NA NA Rat Human DTXSID2048379 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048379 TK.Half.Life NA 2.689 hours 1compartment NA NA Rat Human -DTXSID2048379 Css NA 0.2168 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048379 Css NA 1.164 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048379 Css NA 0.1459 mg/L PBTK NA 50% Rat Human -DTXSID2048379 Css NA 0.7113 mg/L PBTK NA 95% Rat Human +DTXSID2048379 TK.Half.Life NA 1.708 hours 1compartment NA NA Rat Human +DTXSID2048379 Css NA 0.02621 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048379 Css NA 0.1564 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048379 Css NA 0.01847 mg/L PBTK NA 50% Rat Human +DTXSID2048379 Css NA 0.1022 mg/L PBTK NA 95% Rat Human +DTXSID2048535 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID2048535 Fup 0.507 NA NA Williamson 2020 NA Human Human +DTXSID2048535 Vd NA 4.167 L/kg 1compartment NA NA Human Human +DTXSID2048535 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048535 TK.Half.Life NA 10.72 hours 1compartment NA NA Human Human +DTXSID2048535 Css NA 0.1658 mg/L 3compartmentss NA 50% Human Human +DTXSID2048535 Css NA 1.184 mg/L 3compartmentss NA 95% Human Human +DTXSID2048535 Css NA 0.1968 mg/L PBTK NA 50% Human Human +DTXSID2048535 Css NA 1.065 mg/L PBTK NA 95% Human Human +DTXSID2048535 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID2048535 Fup 0.507 NA NA Williamson 2020 NA Rat Human +DTXSID2048535 Vd NA 3.973 L/kg 1compartment NA NA Rat Human +DTXSID2048535 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048535 TK.Half.Life NA 4.53 hours 1compartment NA NA Rat Human +DTXSID2048535 Css NA 0.01823 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048535 Css NA 0.1029 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048535 Css NA 0.02248 mg/L PBTK NA 50% Rat Human +DTXSID2048535 Css NA 0.0866 mg/L PBTK NA 95% Rat Human DTXSID2048539 Clint 1.986 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID2048539 Fup 0.74 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2048539 Vd NA 1.798 L/kg 1compartment NA NA Human Human DTXSID2048539 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2048539 TK.Half.Life NA 5.071 hours 1compartment NA NA Human Human -DTXSID2048539 Css NA 0.1225 mg/L 3compartmentss NA 50% Human Human -DTXSID2048539 Css NA 0.8563 mg/L 3compartmentss NA 95% Human Human -DTXSID2048539 Css NA 0.1077 mg/L PBTK NA 50% Human Human -DTXSID2048539 Css NA 0.5999 mg/L PBTK NA 95% Human Human +DTXSID2048539 Css NA 0.2206 mg/L 3compartmentss NA 50% Human Human +DTXSID2048539 Css NA 1.256 mg/L 3compartmentss NA 95% Human Human +DTXSID2048539 Css NA 0.2196 mg/L PBTK NA 50% Human Human +DTXSID2048539 Css NA 1.254 mg/L PBTK NA 95% Human Human DTXSID2048539 Clint 1.986 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID2048539 Fup 0.74 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2048539 Vd NA 1.552 L/kg 1compartment NA NA Rat Human DTXSID2048539 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2048539 TK.Half.Life NA 1.983 hours 1compartment NA NA Rat Human -DTXSID2048539 Css NA 0.1152 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048539 Css NA 0.7275 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048539 Css NA 0.09957 mg/L PBTK NA 50% Rat Human -DTXSID2048539 Css NA 0.451 mg/L PBTK NA 95% Rat Human -DTXSID2048581 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2048539 Css NA 0.01676 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048539 Css NA 0.08247 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048539 Css NA 0.01729 mg/L PBTK NA 50% Rat Human +DTXSID2048539 Css NA 0.08503 mg/L PBTK NA 95% Rat Human +DTXSID2048581 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2048581 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID2048581 Vd NA 0.8611 L/kg 1compartment NA NA Human Human -DTXSID2048581 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2048581 TK.Half.Life NA 27.85 hours 1compartment NA NA Human Human -DTXSID2048581 Css NA 3.662 mg/L 3compartmentss NA 50% Human Human -DTXSID2048581 Css NA 14.21 mg/L 3compartmentss NA 95% Human Human -DTXSID2048581 Css NA 2.623 mg/L PBTK NA 50% Human Human -DTXSID2048581 Css NA 9.062 mg/L PBTK NA 95% Human Human -DTXSID2048581 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2048581 Vd NA 1.027 L/kg 1compartment NA NA Human Human +DTXSID2048581 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID2048581 TK.Half.Life NA 33.21 hours 1compartment NA NA Human Human +DTXSID2048581 Css NA 1.898 mg/L 3compartmentss NA 50% Human Human +DTXSID2048581 Css NA 8.135 mg/L 3compartmentss NA 95% Human Human +DTXSID2048581 Css NA 1.41 mg/L PBTK NA 50% Human Human +DTXSID2048581 Css NA 5.25 mg/L PBTK NA 95% Human Human +DTXSID2048581 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2048581 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID2048581 Vd NA 0.861 L/kg 1compartment NA NA Rat Human +DTXSID2048581 Vd NA 1.025 L/kg 1compartment NA NA Rat Human DTXSID2048581 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2048581 TK.Half.Life NA 9.491 hours 1compartment NA NA Rat Human -DTXSID2048581 Css NA 1.01 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048581 Css NA 3.216 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048581 Css NA 0.6899 mg/L PBTK NA 50% Rat Human -DTXSID2048581 Css NA 1.903 mg/L PBTK NA 95% Rat Human -DTXSID2048583 Clint NA 3.025 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048583 Fup NA 0.0832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048583 Vd NA 1.639 L/kg 1compartment NA NA Human Human -DTXSID2048583 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2048583 TK.Half.Life NA 24.3 hours 1compartment NA NA Human Human -DTXSID2048583 Css NA 2.12 mg/L 3compartmentss NA 50% Human Human -DTXSID2048583 Css NA 12.85 mg/L 3compartmentss NA 95% Human Human -DTXSID2048583 Css NA 1.467 mg/L PBTK NA 50% Human Human -DTXSID2048583 Css NA 7.905 mg/L PBTK NA 95% Human Human -DTXSID2048583 Clint NA 3.025 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048583 Fup NA 0.0832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048583 Vd NA 1.379 L/kg 1compartment NA NA Rat Human -DTXSID2048583 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2048583 TK.Half.Life NA 10.37 hours 1compartment NA NA Rat Human -DTXSID2048583 Css NA 1.056 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048583 Css NA 4.684 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048583 Css NA 0.6878 mg/L PBTK NA 50% Rat Human -DTXSID2048583 Css NA 2.697 mg/L PBTK NA 95% Rat Human -DTXSID2048585 Clint NA 2.848 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048585 Fup NA 0.0329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048585 Vd NA 0.3439 L/kg 1compartment NA NA Human Human -DTXSID2048585 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2048585 TK.Half.Life NA 11.94 hours 1compartment NA NA Human Human -DTXSID2048585 Css NA 6.077 mg/L 3compartmentss NA 50% Human Human -DTXSID2048585 Css NA 43.79 mg/L 3compartmentss NA 95% Human Human -DTXSID2048585 Css NA 3.743 mg/L PBTK NA 50% Human Human -DTXSID2048585 Css NA 25.63 mg/L PBTK NA 95% Human Human -DTXSID2048585 Clint NA 2.848 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048585 Fup NA 0.0329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048585 Vd NA 0.3302 L/kg 1compartment NA NA Rat Human -DTXSID2048585 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048585 TK.Half.Life NA 6.736 hours 1compartment NA NA Rat Human -DTXSID2048585 Css NA 3.002 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048585 Css NA 17.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048585 Css NA 1.734 mg/L PBTK NA 50% Rat Human -DTXSID2048585 Css NA 9.355 mg/L PBTK NA 95% Rat Human -DTXSID2048587 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048587 Fup NA 0.4177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048587 Vd NA 0.5925 L/kg 1compartment NA NA Human Human +DTXSID2048581 TK.Half.Life NA 11.3 hours 1compartment NA NA Rat Human +DTXSID2048581 Css NA 0.0101 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048581 Css NA 0.04364 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048581 Css NA 0.007158 mg/L PBTK NA 50% Rat Human +DTXSID2048581 Css NA 0.02726 mg/L PBTK NA 95% Rat Human +DTXSID2048583 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048583 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048583 Vd NA 1.556 L/kg 1compartment NA NA Human Human +DTXSID2048583 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048583 TK.Half.Life NA 2.48 hours 1compartment NA NA Human Human +DTXSID2048583 Css NA 0.0994 mg/L 3compartmentss NA 50% Human Human +DTXSID2048583 Css NA 0.7397 mg/L 3compartmentss NA 95% Human Human +DTXSID2048583 Css NA 0.07624 mg/L PBTK NA 50% Human Human +DTXSID2048583 Css NA 0.5074 mg/L PBTK NA 95% Human Human +DTXSID2048583 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048583 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048583 Vd NA 1.438 L/kg 1compartment NA NA Rat Human +DTXSID2048583 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048583 TK.Half.Life NA 1.244 hours 1compartment NA NA Rat Human +DTXSID2048583 Css NA 0.01264 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048583 Css NA 0.06697 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048583 Css NA 0.009757 mg/L PBTK NA 50% Rat Human +DTXSID2048583 Css NA 0.04791 mg/L PBTK NA 95% Rat Human +DTXSID2048587 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048587 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048587 Vd NA 0.5502 L/kg 1compartment NA NA Human Human DTXSID2048587 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048587 TK.Half.Life NA 9.177 hours 1compartment NA NA Human Human -DTXSID2048587 Css NA 1.692 mg/L 3compartmentss NA 50% Human Human -DTXSID2048587 Css NA 7.38 mg/L 3compartmentss NA 95% Human Human -DTXSID2048587 Css NA 1.295 mg/L PBTK NA 50% Human Human -DTXSID2048587 Css NA 4.802 mg/L PBTK NA 95% Human Human -DTXSID2048587 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048587 Fup NA 0.4177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048587 Vd NA 0.6001 L/kg 1compartment NA NA Rat Human +DTXSID2048587 TK.Half.Life NA 6.086 hours 1compartment NA NA Human Human +DTXSID2048587 Css NA 1.283 mg/L 3compartmentss NA 50% Human Human +DTXSID2048587 Css NA 8.554 mg/L 3compartmentss NA 95% Human Human +DTXSID2048587 Css NA 0.98 mg/L PBTK NA 50% Human Human +DTXSID2048587 Css NA 5.32 mg/L PBTK NA 95% Human Human +DTXSID2048587 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048587 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048587 Vd NA 0.5748 L/kg 1compartment NA NA Rat Human DTXSID2048587 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048587 TK.Half.Life NA 3.168 hours 1compartment NA NA Rat Human -DTXSID2048587 Css NA 0.46 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048587 Css NA 1.787 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048587 Css NA 0.3377 mg/L PBTK NA 50% Rat Human -DTXSID2048587 Css NA 1.074 mg/L PBTK NA 95% Rat Human -DTXSID2048589 Clint NA 56.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048589 Fup NA 0.0141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048589 Vd NA 3.089 L/kg 1compartment NA NA Human Human +DTXSID2048587 TK.Half.Life NA 2.167 hours 1compartment NA NA Rat Human +DTXSID2048587 Css NA 0.07746 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048587 Css NA 0.4875 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048587 Css NA 0.059 mg/L PBTK NA 50% Rat Human +DTXSID2048587 Css NA 0.2928 mg/L PBTK NA 95% Rat Human +DTXSID2048589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048589 Fup 0.0528 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048589 Vd NA 3.229 L/kg 1compartment NA NA Human Human DTXSID2048589 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048589 TK.Half.Life NA 12.04 hours 1compartment NA NA Human Human -DTXSID2048589 Css NA 0.3942 mg/L 3compartmentss NA 50% Human Human -DTXSID2048589 Css NA 2.702 mg/L 3compartmentss NA 95% Human Human -DTXSID2048589 Css NA 0.2739 mg/L PBTK NA 50% Human Human -DTXSID2048589 Css NA 1.779 mg/L PBTK NA 95% Human Human -DTXSID2048589 Clint NA 56.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048589 Fup NA 0.0141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048589 Vd NA 2.328 L/kg 1compartment NA NA Rat Human +DTXSID2048589 TK.Half.Life NA 11.61 hours 1compartment NA NA Human Human +DTXSID2048589 Css NA 0.3348 mg/L 3compartmentss NA 50% Human Human +DTXSID2048589 Css NA 2.274 mg/L 3compartmentss NA 95% Human Human +DTXSID2048589 Css NA 0.2406 mg/L PBTK NA 50% Human Human +DTXSID2048589 Css NA 1.578 mg/L PBTK NA 95% Human Human +DTXSID2048589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048589 Fup 0.0528 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048589 Vd NA 2.481 L/kg 1compartment NA NA Rat Human DTXSID2048589 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048589 TK.Half.Life NA 2.205 hours 1compartment NA NA Rat Human -DTXSID2048589 Css NA 0.224 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048589 Css NA 1.187 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048589 Css NA 0.1485 mg/L PBTK NA 50% Rat Human -DTXSID2048589 Css NA 0.7657 mg/L PBTK NA 95% Rat Human -DTXSID2048610 Clint NA 14.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048610 Fup NA 0.0223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048610 Vd NA 0.2415 L/kg 1compartment NA NA Human Human +DTXSID2048589 TK.Half.Life NA 2.176 hours 1compartment NA NA Rat Human +DTXSID2048589 Css NA 0.04343 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048589 Css NA 0.2535 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048589 Css NA 0.03108 mg/L PBTK NA 50% Rat Human +DTXSID2048589 Css NA 0.1748 mg/L PBTK NA 95% Rat Human +DTXSID2048610 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048610 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048610 Vd NA 0.2569 L/kg 1compartment NA NA Human Human DTXSID2048610 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048610 TK.Half.Life NA 2.997 hours 1compartment NA NA Human Human -DTXSID2048610 Css NA 2.22 mg/L 3compartmentss NA 50% Human Human -DTXSID2048610 Css NA 20.76 mg/L 3compartmentss NA 95% Human Human -DTXSID2048610 Css NA 1.324 mg/L PBTK NA 50% Human Human -DTXSID2048610 Css NA 12.09 mg/L PBTK NA 95% Human Human -DTXSID2048610 Clint NA 14.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048610 Fup NA 0.0223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048610 Vd NA 0.2259 L/kg 1compartment NA NA Rat Human +DTXSID2048610 TK.Half.Life NA 6.863 hours 1compartment NA NA Human Human +DTXSID2048610 Css NA 4.765 mg/L 3compartmentss NA 50% Human Human +DTXSID2048610 Css NA 40.88 mg/L 3compartmentss NA 95% Human Human +DTXSID2048610 Css NA 2.85 mg/L PBTK NA 50% Human Human +DTXSID2048610 Css NA 23.61 mg/L PBTK NA 95% Human Human +DTXSID2048610 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048610 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048610 Vd NA 0.2365 L/kg 1compartment NA NA Rat Human DTXSID2048610 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048610 TK.Half.Life NA 1.832 hours 1compartment NA NA Rat Human -DTXSID2048610 Css NA 1.228 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048610 Css NA 9.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048610 Css NA 0.6806 mg/L PBTK NA 50% Rat Human -DTXSID2048610 Css NA 4.951 mg/L PBTK NA 95% Rat Human -DTXSID2048612 Clint NA 3.612 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048612 Fup NA 0.2163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048612 Vd NA 1.765 L/kg 1compartment NA NA Human Human +DTXSID2048610 TK.Half.Life NA 4.007 hours 1compartment NA NA Rat Human +DTXSID2048610 Css NA 0.5766 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048610 Css NA 3.946 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048610 Css NA 0.3317 mg/L PBTK NA 50% Rat Human +DTXSID2048610 Css NA 2.234 mg/L PBTK NA 95% Rat Human +DTXSID2048612 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048612 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048612 Vd NA 2.566 L/kg 1compartment NA NA Human Human DTXSID2048612 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048612 TK.Half.Life NA 11.2 hours 1compartment NA NA Human Human -DTXSID2048612 Css NA 0.6888 mg/L 3compartmentss NA 50% Human Human -DTXSID2048612 Css NA 3.344 mg/L 3compartmentss NA 95% Human Human -DTXSID2048612 Css NA 0.5062 mg/L PBTK NA 50% Human Human -DTXSID2048612 Css NA 2.302 mg/L PBTK NA 95% Human Human -DTXSID2048612 Clint NA 3.612 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048612 Fup NA 0.2163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048612 Vd NA 1.379 L/kg 1compartment NA NA Rat Human +DTXSID2048612 TK.Half.Life NA 7.198 hours 1compartment NA NA Human Human +DTXSID2048612 Css NA 0.2406 mg/L 3compartmentss NA 50% Human Human +DTXSID2048612 Css NA 1.536 mg/L 3compartmentss NA 95% Human Human +DTXSID2048612 Css NA 0.1748 mg/L PBTK NA 50% Human Human +DTXSID2048612 Css NA 1.066 mg/L PBTK NA 95% Human Human +DTXSID2048612 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048612 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048612 Vd NA 1.953 L/kg 1compartment NA NA Rat Human DTXSID2048612 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048612 TK.Half.Life NA 3.923 hours 1compartment NA NA Rat Human -DTXSID2048612 Css NA 0.3378 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048612 Css NA 1.205 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048612 Css NA 0.2365 mg/L PBTK NA 50% Rat Human -DTXSID2048612 Css NA 0.7618 mg/L PBTK NA 95% Rat Human -DTXSID2048614 Clint NA 103.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048614 Fup NA 0.5036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048614 Vd NA 3.14 L/kg 1compartment NA NA Human Human -DTXSID2048614 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2048614 TK.Half.Life NA 16.63 hours 1compartment NA NA Human Human -DTXSID2048614 Css NA 0.5526 mg/L 3compartmentss NA 50% Human Human -DTXSID2048614 Css NA 3.624 mg/L 3compartmentss NA 95% Human Human -DTXSID2048614 Css NA 0.3862 mg/L PBTK NA 50% Human Human -DTXSID2048614 Css NA 2.411 mg/L PBTK NA 95% Human Human -DTXSID2048614 Clint NA 103.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048614 Fup NA 0.5036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048614 Vd NA 2.355 L/kg 1compartment NA NA Rat Human +DTXSID2048612 TK.Half.Life NA 1.921 hours 1compartment NA NA Rat Human +DTXSID2048612 Css NA 0.03039 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048612 Css NA 0.1516 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048612 Css NA 0.02197 mg/L PBTK NA 50% Rat Human +DTXSID2048612 Css NA 0.1036 mg/L PBTK NA 95% Rat Human +DTXSID2048614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048614 Fup 0.0892 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048614 Vd NA 0.4772 L/kg 1compartment NA NA Human Human +DTXSID2048614 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048614 TK.Half.Life NA 1.33 hours 1compartment NA NA Human Human +DTXSID2048614 Css NA 0.317 mg/L 3compartmentss NA 50% Human Human +DTXSID2048614 Css NA 2.559 mg/L 3compartmentss NA 95% Human Human +DTXSID2048614 Css NA 0.1989 mg/L PBTK NA 50% Human Human +DTXSID2048614 Css NA 1.533 mg/L PBTK NA 95% Human Human +DTXSID2048614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048614 Fup 0.0892 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048614 Vd NA 0.427 L/kg 1compartment NA NA Rat Human DTXSID2048614 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048614 TK.Half.Life NA 2.615 hours 1compartment NA NA Rat Human -DTXSID2048614 Css NA 0.3122 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048614 Css NA 1.691 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048614 Css NA 0.2086 mg/L PBTK NA 50% Rat Human -DTXSID2048614 Css NA 1.075 mg/L PBTK NA 95% Rat Human +DTXSID2048614 TK.Half.Life NA 0.7087 hours 1compartment NA NA Rat Human +DTXSID2048614 Css NA 0.04186 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048614 Css NA 0.2667 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048614 Css NA 0.02535 mg/L PBTK NA 50% Rat Human +DTXSID2048614 Css NA 0.1546 mg/L PBTK NA 95% Rat Human DTXSID2048616 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2048616 Fup NA 0.7441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048616 Vd NA 0.5742 L/kg 1compartment NA NA Human Human +DTXSID2048616 Vd NA 0.5971 L/kg 1compartment NA NA Human Human DTXSID2048616 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048616 TK.Half.Life NA 4.994 hours 1compartment NA NA Human Human -DTXSID2048616 Css NA 1.095 mg/L 3compartmentss NA 50% Human Human -DTXSID2048616 Css NA 6.561 mg/L 3compartmentss NA 95% Human Human -DTXSID2048616 Css NA 0.8514 mg/L PBTK NA 50% Human Human -DTXSID2048616 Css NA 4.128 mg/L PBTK NA 95% Human Human +DTXSID2048616 TK.Half.Life NA 5.192 hours 1compartment NA NA Human Human +DTXSID2048616 Css NA 0.923 mg/L 3compartmentss NA 50% Human Human +DTXSID2048616 Css NA 5.811 mg/L 3compartmentss NA 95% Human Human +DTXSID2048616 Css NA 0.7248 mg/L PBTK NA 50% Human Human +DTXSID2048616 Css NA 3.683 mg/L PBTK NA 95% Human Human DTXSID2048616 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2048616 Fup NA 0.7441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048616 Vd NA 0.6121 L/kg 1compartment NA NA Rat Human +DTXSID2048616 Vd NA 0.6313 L/kg 1compartment NA NA Rat Human DTXSID2048616 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048616 TK.Half.Life NA 1.814 hours 1compartment NA NA Rat Human -DTXSID2048616 Css NA 0.2846 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048616 Css NA 1.735 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048616 Css NA 0.2123 mg/L PBTK NA 50% Rat Human -DTXSID2048616 Css NA 1.012 mg/L PBTK NA 95% Rat Human -DTXSID2048618 Clint NA 0.0863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048618 Fup NA 0.2532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048618 Vd NA 0.2816 L/kg 1compartment NA NA Human Human +DTXSID2048616 TK.Half.Life NA 1.871 hours 1compartment NA NA Rat Human +DTXSID2048616 Css NA 0.01795 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048616 Css NA 0.1358 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048616 Css NA 0.01346 mg/L PBTK NA 50% Rat Human +DTXSID2048616 Css NA 0.08471 mg/L PBTK NA 95% Rat Human +DTXSID2048618 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048618 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048618 Vd NA 0.2873 L/kg 1compartment NA NA Human Human DTXSID2048618 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048618 TK.Half.Life NA 6.279 hours 1compartment NA NA Human Human -DTXSID2048618 Css NA 2.772 mg/L 3compartmentss NA 50% Human Human -DTXSID2048618 Css NA 10.34 mg/L 3compartmentss NA 95% Human Human -DTXSID2048618 Css NA 1.774 mg/L PBTK NA 50% Human Human -DTXSID2048618 Css NA 6.174 mg/L PBTK NA 95% Human Human -DTXSID2048618 Clint NA 0.0863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048618 Fup NA 0.2532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048618 Vd NA 0.2883 L/kg 1compartment NA NA Rat Human +DTXSID2048618 TK.Half.Life NA 0.7758 hours 1compartment NA NA Human Human +DTXSID2048618 Css NA 0.133 mg/L 3compartmentss NA 50% Human Human +DTXSID2048618 Css NA 0.9025 mg/L 3compartmentss NA 95% Human Human +DTXSID2048618 Css NA 0.08542 mg/L PBTK NA 50% Human Human +DTXSID2048618 Css NA 0.5628 mg/L PBTK NA 95% Human Human +DTXSID2048618 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048618 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048618 Vd NA 0.2953 L/kg 1compartment NA NA Rat Human DTXSID2048618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048618 TK.Half.Life NA 2.344 hours 1compartment NA NA Rat Human -DTXSID2048618 Css NA 0.8464 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048618 Css NA 2.627 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048618 Css NA 0.5118 mg/L PBTK NA 50% Rat Human -DTXSID2048618 Css NA 1.475 mg/L PBTK NA 95% Rat Human -DTXSID2048660 Clint NA 1.105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048660 Fup NA 0.0491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048660 Vd NA 0.1936 L/kg 1compartment NA NA Human Human +DTXSID2048618 TK.Half.Life NA 0.4548 hours 1compartment NA NA Rat Human +DTXSID2048618 Css NA 0.001276 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048618 Css NA 0.007456 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048618 Css NA 0.0007848 mg/L PBTK NA 50% Rat Human +DTXSID2048618 Css NA 0.004327 mg/L PBTK NA 95% Rat Human +DTXSID2048660 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048660 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048660 Vd NA 0.5468 L/kg 1compartment NA NA Human Human DTXSID2048660 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048660 TK.Half.Life NA 9.018 hours 1compartment NA NA Human Human -DTXSID2048660 Css NA 8.04 mg/L 3compartmentss NA 50% Human Human -DTXSID2048660 Css NA 45.67 mg/L 3compartmentss NA 95% Human Human -DTXSID2048660 Css NA 4.764 mg/L PBTK NA 50% Human Human -DTXSID2048660 Css NA 26.32 mg/L PBTK NA 95% Human Human -DTXSID2048660 Clint NA 1.105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048660 Fup NA 0.0491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048660 Vd NA 0.1932 L/kg 1compartment NA NA Rat Human +DTXSID2048660 TK.Half.Life NA 1.359 hours 1compartment NA NA Human Human +DTXSID2048660 Css NA 0.1884 mg/L 3compartmentss NA 50% Human Human +DTXSID2048660 Css NA 1.198 mg/L 3compartmentss NA 95% Human Human +DTXSID2048660 Css NA 0.1334 mg/L PBTK NA 50% Human Human +DTXSID2048660 Css NA 0.7811 mg/L PBTK NA 95% Human Human +DTXSID2048660 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048660 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048660 Vd NA 0.5361 L/kg 1compartment NA NA Rat Human DTXSID2048660 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048660 TK.Half.Life NA 4.584 hours 1compartment NA NA Rat Human -DTXSID2048660 Css NA 3.457 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048660 Css NA 15.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048660 Css NA 1.906 mg/L PBTK NA 50% Rat Human -DTXSID2048660 Css NA 8.521 mg/L PBTK NA 95% Rat Human +DTXSID2048660 TK.Half.Life NA 0.7573 hours 1compartment NA NA Rat Human +DTXSID2048660 Css NA 0.008332 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048660 Css NA 0.06291 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048660 Css NA 0.005822 mg/L PBTK NA 50% Rat Human +DTXSID2048660 Css NA 0.04002 mg/L PBTK NA 95% Rat Human DTXSID2048662 Clint NA 11.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2048662 Fup NA 0.8502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048662 Vd NA 1.778 L/kg 1compartment NA NA Human Human +DTXSID2048662 Vd NA 0.5812 L/kg 1compartment NA NA Human Human DTXSID2048662 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048662 TK.Half.Life NA 1.45 hours 1compartment NA NA Human Human -DTXSID2048662 Css NA 0.04301 mg/L 3compartmentss NA 50% Human Human -DTXSID2048662 Css NA 0.4179 mg/L 3compartmentss NA 95% Human Human -DTXSID2048662 Css NA 0.04078 mg/L PBTK NA 50% Human Human -DTXSID2048662 Css NA 0.3192 mg/L PBTK NA 95% Human Human +DTXSID2048662 TK.Half.Life NA 0.3669 hours 1compartment NA NA Human Human +DTXSID2048662 Css NA 0.0005124 mg/L 3compartmentss NA 50% Human Human +DTXSID2048662 Css NA 0.01464 mg/L 3compartmentss NA 95% Human Human +DTXSID2048662 Css NA 0.0003961 mg/L PBTK NA 50% Human Human +DTXSID2048662 Css NA 0.01016 mg/L PBTK NA 95% Human Human DTXSID2048662 Clint NA 11.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2048662 Fup NA 0.8502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048662 Vd NA 1.809 L/kg 1compartment NA NA Rat Human +DTXSID2048662 Vd NA 0.6307 L/kg 1compartment NA NA Rat Human DTXSID2048662 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048662 TK.Half.Life NA 0.7632 hours 1compartment NA NA Rat Human -DTXSID2048662 Css NA 0.02105 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048662 Css NA 0.1781 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048662 Css NA 0.02023 mg/L PBTK NA 50% Rat Human -DTXSID2048662 Css NA 0.1237 mg/L PBTK NA 95% Rat Human -DTXSID2048664 Clint NA 159.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048664 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048664 Vd NA 26.79 L/kg 1compartment NA NA Human Human -DTXSID2048664 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID2048664 TK.Half.Life NA 112.3 hours 1compartment NA NA Human Human -DTXSID2048664 Css NA 0.1159 mg/L 3compartmentss NA 50% Human Human -DTXSID2048664 Css NA 0.7329 mg/L 3compartmentss NA 95% Human Human -DTXSID2048664 Css NA 0.3267 mg/L PBTK NA 50% Human Human -DTXSID2048664 Css NA 1.9 mg/L PBTK NA 95% Human Human -DTXSID2048664 Clint NA 159.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048664 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048664 Vd NA 22.02 L/kg 1compartment NA NA Rat Human -DTXSID2048664 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID2048664 TK.Half.Life NA 16.95 hours 1compartment NA NA Rat Human -DTXSID2048664 Css NA 0.06094 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048664 Css NA 0.2686 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048664 Css NA 0.1784 mg/L PBTK NA 50% Rat Human -DTXSID2048664 Css NA 0.7879 mg/L PBTK NA 95% Rat Human -DTXSID2048666 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048666 Fup NA 0.1287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048666 Vd NA 2.857 L/kg 1compartment NA NA Human Human -DTXSID2048666 Days.Css NA 30 Days PBTK NA NA Human Human -DTXSID2048666 TK.Half.Life NA 150.4 hours 1compartment NA NA Human Human -DTXSID2048666 Css NA 5.198 mg/L 3compartmentss NA 50% Human Human -DTXSID2048666 Css NA 30.58 mg/L 3compartmentss NA 95% Human Human -DTXSID2048666 Css NA 4.932 mg/L PBTK NA 50% Human Human -DTXSID2048666 Css NA 20.95 mg/L PBTK NA 95% Human Human -DTXSID2048666 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048666 Fup NA 0.1287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048666 Vd NA 2.852 L/kg 1compartment NA NA Rat Human -DTXSID2048666 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID2048666 TK.Half.Life NA 49.4 hours 1compartment NA NA Rat Human -DTXSID2048666 Css NA 1.392 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048666 Css NA 7.085 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048666 Css NA 1.299 mg/L PBTK NA 50% Rat Human -DTXSID2048666 Css NA 4.612 mg/L PBTK NA 95% Rat Human -DTXSID2048668 Clint NA 13.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048668 Fup NA 0.1187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048668 Vd NA 0.2829 L/kg 1compartment NA NA Human Human +DTXSID2048662 TK.Half.Life NA 0.1725 hours 1compartment NA NA Rat Human +DTXSID2048662 Css NA 1.54e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048662 Css NA 0.0005986 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048662 Css NA 1.176e-05 mg/L PBTK NA 50% Rat Human +DTXSID2048662 Css NA 0.0004004 mg/L PBTK NA 95% Rat Human +DTXSID2048664 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048664 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048664 Vd NA 35.08 L/kg 1compartment NA NA Human Human +DTXSID2048664 Days.Css NA 253 Days PBTK NA NA Human Human +DTXSID2048664 TK.Half.Life NA 1035 hours 1compartment NA NA Human Human +DTXSID2048664 Css NA 0.6293 mg/L 3compartmentss NA 50% Human Human +DTXSID2048664 Css NA 4.025 mg/L 3compartmentss NA 95% Human Human +DTXSID2048664 Css NA 2.361 mg/L PBTK NA 50% Human Human +DTXSID2048664 Css NA 14.03 mg/L PBTK NA 95% Human Human +DTXSID2048664 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048664 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048664 Vd NA 29.16 L/kg 1compartment NA NA Rat Human +DTXSID2048664 Days.Css NA 155 Days PBTK NA NA Rat Human +DTXSID2048664 TK.Half.Life NA 148.3 hours 1compartment NA NA Rat Human +DTXSID2048664 Css NA 0.0753 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048664 Css NA 0.3445 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048664 Css NA 0.3076 mg/L PBTK NA 50% Rat Human +DTXSID2048664 Css NA 1.477 mg/L PBTK NA 95% Rat Human +DTXSID2048666 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048666 Fup 0.0571 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048666 Vd NA 1.522 L/kg 1compartment NA NA Human Human +DTXSID2048666 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2048666 TK.Half.Life NA 11.74 hours 1compartment NA NA Human Human +DTXSID2048666 Css NA 1.037 mg/L 3compartmentss NA 50% Human Human +DTXSID2048666 Css NA 8.098 mg/L 3compartmentss NA 95% Human Human +DTXSID2048666 Css NA 0.752 mg/L PBTK NA 50% Human Human +DTXSID2048666 Css NA 5.222 mg/L PBTK NA 95% Human Human +DTXSID2048666 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048666 Fup 0.0571 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048666 Vd NA 1.499 L/kg 1compartment NA NA Rat Human +DTXSID2048666 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048666 TK.Half.Life NA 7.281 hours 1compartment NA NA Rat Human +DTXSID2048666 Css NA 0.1282 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048666 Css NA 0.8012 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048666 Css NA 0.09176 mg/L PBTK NA 50% Rat Human +DTXSID2048666 Css NA 0.4958 mg/L PBTK NA 95% Rat Human +DTXSID2048668 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048668 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048668 Vd NA 0.3564 L/kg 1compartment NA NA Human Human DTXSID2048668 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048668 TK.Half.Life NA 0.8623 hours 1compartment NA NA Human Human -DTXSID2048668 Css NA 0.3744 mg/L 3compartmentss NA 50% Human Human -DTXSID2048668 Css NA 2.808 mg/L 3compartmentss NA 95% Human Human -DTXSID2048668 Css NA 0.2332 mg/L PBTK NA 50% Human Human -DTXSID2048668 Css NA 1.695 mg/L PBTK NA 95% Human Human -DTXSID2048668 Clint NA 13.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048668 Fup NA 0.1187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048668 Vd NA 0.2834 L/kg 1compartment NA NA Rat Human +DTXSID2048668 TK.Half.Life NA 9.451 hours 1compartment NA NA Human Human +DTXSID2048668 Css NA 2.752 mg/L 3compartmentss NA 50% Human Human +DTXSID2048668 Css NA 10.01 mg/L 3compartmentss NA 95% Human Human +DTXSID2048668 Css NA 1.842 mg/L PBTK NA 50% Human Human +DTXSID2048668 Css NA 6.206 mg/L PBTK NA 95% Human Human +DTXSID2048668 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048668 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048668 Vd NA 0.362 L/kg 1compartment NA NA Rat Human DTXSID2048668 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048668 TK.Half.Life NA 0.5177 hours 1compartment NA NA Rat Human -DTXSID2048668 Css NA 0.2046 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048668 Css NA 1.151 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048668 Css NA 0.1194 mg/L PBTK NA 50% Rat Human -DTXSID2048668 Css NA 0.6366 mg/L PBTK NA 95% Rat Human -DTXSID2048741 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048741 Fup NA 0.5316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048741 Vd NA 0.3637 L/kg 1compartment NA NA Human Human +DTXSID2048668 TK.Half.Life NA 3.271 hours 1compartment NA NA Rat Human +DTXSID2048668 Css NA 0.04929 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048668 Css NA 0.2852 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048668 Css NA 0.03156 mg/L PBTK NA 50% Rat Human +DTXSID2048668 Css NA 0.1721 mg/L PBTK NA 95% Rat Human +DTXSID2048741 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048741 Fup 0.536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048741 Vd NA 0.342 L/kg 1compartment NA NA Human Human DTXSID2048741 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048741 TK.Half.Life NA 4.426 hours 1compartment NA NA Human Human -DTXSID2048741 Css NA 1.542 mg/L 3compartmentss NA 50% Human Human -DTXSID2048741 Css NA 8.699 mg/L 3compartmentss NA 95% Human Human -DTXSID2048741 Css NA 1.07 mg/L PBTK NA 50% Human Human -DTXSID2048741 Css NA 5.276 mg/L PBTK NA 95% Human Human -DTXSID2048741 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048741 Fup NA 0.5316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048741 Vd NA 0.3793 L/kg 1compartment NA NA Rat Human +DTXSID2048741 TK.Half.Life NA 4.128 hours 1compartment NA NA Human Human +DTXSID2048741 Css NA 1.3 mg/L 3compartmentss NA 50% Human Human +DTXSID2048741 Css NA 7.403 mg/L 3compartmentss NA 95% Human Human +DTXSID2048741 Css NA 0.8986 mg/L PBTK NA 50% Human Human +DTXSID2048741 Css NA 4.455 mg/L PBTK NA 95% Human Human +DTXSID2048741 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048741 Fup 0.536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048741 Vd NA 0.3612 L/kg 1compartment NA NA Rat Human DTXSID2048741 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048741 TK.Half.Life NA 1.574 hours 1compartment NA NA Rat Human -DTXSID2048741 Css NA 0.4105 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048741 Css NA 2 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048741 Css NA 0.2713 mg/L PBTK NA 50% Rat Human -DTXSID2048741 Css NA 1.138 mg/L PBTK NA 95% Rat Human -DTXSID2048743 Clint NA 33.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048743 Fup NA 0.0721 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048743 Vd NA 0.2299 L/kg 1compartment NA NA Human Human +DTXSID2048741 TK.Half.Life NA 1.486 hours 1compartment NA NA Rat Human +DTXSID2048741 Css NA 0.02494 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048741 Css NA 0.1811 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048741 Css NA 0.0164 mg/L PBTK NA 50% Rat Human +DTXSID2048741 Css NA 0.1075 mg/L PBTK NA 95% Rat Human +DTXSID2048743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048743 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048743 Vd NA 0.3526 L/kg 1compartment NA NA Human Human DTXSID2048743 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048743 TK.Half.Life NA 0.5738 hours 1compartment NA NA Human Human -DTXSID2048743 Css NA 0.2872 mg/L 3compartmentss NA 50% Human Human -DTXSID2048743 Css NA 2.346 mg/L 3compartmentss NA 95% Human Human -DTXSID2048743 Css NA 0.1731 mg/L PBTK NA 50% Human Human -DTXSID2048743 Css NA 1.393 mg/L PBTK NA 95% Human Human -DTXSID2048743 Clint NA 33.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048743 Fup NA 0.0721 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048743 Vd NA 0.2256 L/kg 1compartment NA NA Rat Human +DTXSID2048743 TK.Half.Life NA 0.6997 hours 1compartment NA NA Human Human +DTXSID2048743 Css NA 0.1467 mg/L 3compartmentss NA 50% Human Human +DTXSID2048743 Css NA 1.251 mg/L 3compartmentss NA 95% Human Human +DTXSID2048743 Css NA 0.09214 mg/L PBTK NA 50% Human Human +DTXSID2048743 Css NA 0.7647 mg/L PBTK NA 95% Human Human +DTXSID2048743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048743 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048743 Vd NA 0.3325 L/kg 1compartment NA NA Rat Human DTXSID2048743 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048743 TK.Half.Life NA 0.3328 hours 1compartment NA NA Rat Human -DTXSID2048743 Css NA 0.1646 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048743 Css NA 1.009 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048743 Css NA 0.09202 mg/L PBTK NA 50% Rat Human -DTXSID2048743 Css NA 0.5559 mg/L PBTK NA 95% Rat Human -DTXSID2048745 Clint NA 44.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048745 Fup NA 0.0676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048745 Vd NA 2.044 L/kg 1compartment NA NA Human Human -DTXSID2048745 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048745 TK.Half.Life NA 5.352 hours 1compartment NA NA Human Human -DTXSID2048745 Css NA 0.2616 mg/L 3compartmentss NA 50% Human Human -DTXSID2048745 Css NA 1.741 mg/L 3compartmentss NA 95% Human Human -DTXSID2048745 Css NA 0.1741 mg/L PBTK NA 50% Human Human -DTXSID2048745 Css NA 1.106 mg/L PBTK NA 95% Human Human -DTXSID2048745 Clint NA 44.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048745 Fup NA 0.0676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048745 Vd NA 1.537 L/kg 1compartment NA NA Rat Human -DTXSID2048745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048745 TK.Half.Life NA 1.743 hours 1compartment NA NA Rat Human -DTXSID2048745 Css NA 0.1458 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048745 Css NA 0.7806 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048745 Css NA 0.09222 mg/L PBTK NA 50% Rat Human -DTXSID2048745 Css NA 0.4797 mg/L PBTK NA 95% Rat Human -DTXSID2048747 Clint NA 4.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048747 Fup NA 0.1341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048747 Vd NA 1.58 L/kg 1compartment NA NA Human Human +DTXSID2048743 TK.Half.Life NA 0.3745 hours 1compartment NA NA Rat Human +DTXSID2048743 Css NA 0.00712 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048743 Css NA 0.06466 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048743 Css NA 0.004397 mg/L PBTK NA 50% Rat Human +DTXSID2048743 Css NA 0.03763 mg/L PBTK NA 95% Rat Human +DTXSID2048745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048745 Fup 0.0739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048745 Vd NA 3.124 L/kg 1compartment NA NA Human Human +DTXSID2048745 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID2048745 TK.Half.Life NA 75.32 hours 1compartment NA NA Human Human +DTXSID2048745 Css NA 2.827 mg/L 3compartmentss NA 50% Human Human +DTXSID2048745 Css NA 18.33 mg/L 3compartmentss NA 95% Human Human +DTXSID2048745 Css NA 1.97 mg/L PBTK NA 50% Human Human +DTXSID2048745 Css NA 12.34 mg/L PBTK NA 95% Human Human +DTXSID2048745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048745 Fup 0.0739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048745 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID2048745 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID2048745 TK.Half.Life NA 10.18 hours 1compartment NA NA Rat Human +DTXSID2048745 Css NA 0.3651 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048745 Css NA 2.061 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048745 Css NA 0.2519 mg/L PBTK NA 50% Rat Human +DTXSID2048745 Css NA 1.399 mg/L PBTK NA 95% Rat Human +DTXSID2048747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048747 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048747 Vd NA 4.144 L/kg 1compartment NA NA Human Human DTXSID2048747 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048747 TK.Half.Life NA 8.768 hours 1compartment NA NA Human Human -DTXSID2048747 Css NA 0.6694 mg/L 3compartmentss NA 50% Human Human -DTXSID2048747 Css NA 4.655 mg/L 3compartmentss NA 95% Human Human -DTXSID2048747 Css NA 0.5063 mg/L PBTK NA 50% Human Human -DTXSID2048747 Css NA 3.081 mg/L PBTK NA 95% Human Human -DTXSID2048747 Clint NA 4.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048747 Fup NA 0.1341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048747 Vd NA 1.551 L/kg 1compartment NA NA Rat Human +DTXSID2048747 TK.Half.Life NA 2.792 hours 1compartment NA NA Human Human +DTXSID2048747 Css NA 0.02092 mg/L 3compartmentss NA 50% Human Human +DTXSID2048747 Css NA 0.2764 mg/L 3compartmentss NA 95% Human Human +DTXSID2048747 Css NA 0.0272 mg/L PBTK NA 50% Human Human +DTXSID2048747 Css NA 0.25 mg/L PBTK NA 95% Human Human +DTXSID2048747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048747 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048747 Vd NA 4.172 L/kg 1compartment NA NA Rat Human DTXSID2048747 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048747 TK.Half.Life NA 5.115 hours 1compartment NA NA Rat Human -DTXSID2048747 Css NA 0.3372 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048747 Css NA 1.866 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048747 Css NA 0.2454 mg/L PBTK NA 50% Rat Human -DTXSID2048747 Css NA 1.129 mg/L PBTK NA 95% Rat Human -DTXSID2048749 Clint NA 53.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048749 Fup NA 0.2014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048749 Vd NA 3.391 L/kg 1compartment NA NA Human Human +DTXSID2048747 TK.Half.Life NA 1.438 hours 1compartment NA NA Rat Human +DTXSID2048747 Css NA 0.002482 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048747 Css NA 0.02731 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048747 Css NA 0.003394 mg/L PBTK NA 50% Rat Human +DTXSID2048747 Css NA 0.02382 mg/L PBTK NA 95% Rat Human +DTXSID2048749 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048749 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048749 Vd NA 3.124 L/kg 1compartment NA NA Human Human DTXSID2048749 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048749 TK.Half.Life NA 2.403 hours 1compartment NA NA Human Human -DTXSID2048749 Css NA 0.01947 mg/L 3compartmentss NA 50% Human Human -DTXSID2048749 Css NA 0.1601 mg/L 3compartmentss NA 95% Human Human -DTXSID2048749 Css NA 0.02242 mg/L PBTK NA 50% Human Human -DTXSID2048749 Css NA 0.1498 mg/L PBTK NA 95% Human Human -DTXSID2048749 Clint NA 53.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048749 Fup NA 0.2014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048749 Vd NA 3.411 L/kg 1compartment NA NA Rat Human +DTXSID2048749 TK.Half.Life NA 8.665 hours 1compartment NA NA Human Human +DTXSID2048749 Css NA 0.1808 mg/L 3compartmentss NA 50% Human Human +DTXSID2048749 Css NA 1.315 mg/L 3compartmentss NA 95% Human Human +DTXSID2048749 Css NA 0.1984 mg/L PBTK NA 50% Human Human +DTXSID2048749 Css NA 1.146 mg/L PBTK NA 95% Human Human +DTXSID2048749 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048749 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048749 Vd NA 3.136 L/kg 1compartment NA NA Rat Human DTXSID2048749 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048749 TK.Half.Life NA 1.256 hours 1compartment NA NA Rat Human -DTXSID2048749 Css NA 0.01028 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048749 Css NA 0.073 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048749 Css NA 0.0119 mg/L PBTK NA 50% Rat Human -DTXSID2048749 Css NA 0.06577 mg/L PBTK NA 95% Rat Human -DTXSID2048791 Clint NA 37.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048791 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048791 Vd NA 1.016 L/kg 1compartment NA NA Human Human +DTXSID2048749 TK.Half.Life NA 5.263 hours 1compartment NA NA Rat Human +DTXSID2048749 Css NA 0.02118 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048749 Css NA 0.1183 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048749 Css NA 0.02396 mg/L PBTK NA 50% Rat Human +DTXSID2048749 Css NA 0.1018 mg/L PBTK NA 95% Rat Human +DTXSID2048791 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048791 Fup 0.829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048791 Vd NA 0.9098 L/kg 1compartment NA NA Human Human DTXSID2048791 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048791 TK.Half.Life NA 0.6307 hours 1compartment NA NA Human Human -DTXSID2048791 Css NA 0.01352 mg/L 3compartmentss NA 50% Human Human -DTXSID2048791 Css NA 0.1834 mg/L 3compartmentss NA 95% Human Human -DTXSID2048791 Css NA 0.0116 mg/L PBTK NA 50% Human Human -DTXSID2048791 Css NA 0.1374 mg/L PBTK NA 95% Human Human -DTXSID2048791 Clint NA 37.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048791 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048791 Vd NA 1.054 L/kg 1compartment NA NA Rat Human +DTXSID2048791 TK.Half.Life NA 7.102 hours 1compartment NA NA Human Human +DTXSID2048791 Css NA 0.8188 mg/L 3compartmentss NA 50% Human Human +DTXSID2048791 Css NA 5.051 mg/L 3compartmentss NA 95% Human Human +DTXSID2048791 Css NA 0.6924 mg/L PBTK NA 50% Human Human +DTXSID2048791 Css NA 3.288 mg/L PBTK NA 95% Human Human +DTXSID2048791 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048791 Fup 0.829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048791 Vd NA 0.9434 L/kg 1compartment NA NA Rat Human DTXSID2048791 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048791 TK.Half.Life NA 0.3014 hours 1compartment NA NA Rat Human -DTXSID2048791 Css NA 0.006848 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048791 Css NA 0.07403 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048791 Css NA 0.005808 mg/L PBTK NA 50% Rat Human -DTXSID2048791 Css NA 0.05408 mg/L PBTK NA 95% Rat Human -DTXSID2048793 Clint NA 72.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048793 Fup NA 0.2308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048793 Vd NA 0.7984 L/kg 1compartment NA NA Human Human +DTXSID2048791 TK.Half.Life NA 2.51 hours 1compartment NA NA Rat Human +DTXSID2048791 Css NA 0.02064 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048791 Css NA 0.1561 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048791 Css NA 0.01695 mg/L PBTK NA 50% Rat Human +DTXSID2048791 Css NA 0.1004 mg/L PBTK NA 95% Rat Human +DTXSID2048793 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048793 Fup 0.25 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048793 Vd NA 1.07 L/kg 1compartment NA NA Human Human DTXSID2048793 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048793 TK.Half.Life NA 0.8031 hours 1compartment NA NA Human Human -DTXSID2048793 Css NA 0.02957 mg/L 3compartmentss NA 50% Human Human -DTXSID2048793 Css NA 0.2123 mg/L 3compartmentss NA 95% Human Human -DTXSID2048793 Css NA 0.0207 mg/L PBTK NA 50% Human Human -DTXSID2048793 Css NA 0.1429 mg/L PBTK NA 95% Human Human -DTXSID2048793 Clint NA 72.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048793 Fup NA 0.2308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048793 Vd NA 0.7002 L/kg 1compartment NA NA Rat Human +DTXSID2048793 TK.Half.Life NA 3.279 hours 1compartment NA NA Human Human +DTXSID2048793 Css NA 0.2805 mg/L 3compartmentss NA 50% Human Human +DTXSID2048793 Css NA 1.751 mg/L 3compartmentss NA 95% Human Human +DTXSID2048793 Css NA 0.2037 mg/L PBTK NA 50% Human Human +DTXSID2048793 Css NA 1.159 mg/L PBTK NA 95% Human Human +DTXSID2048793 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048793 Fup 0.25 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048793 Vd NA 0.8928 L/kg 1compartment NA NA Rat Human DTXSID2048793 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048793 TK.Half.Life NA 0.3411 hours 1compartment NA NA Rat Human -DTXSID2048793 Css NA 0.01623 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048793 Css NA 0.09949 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048793 Css NA 0.01091 mg/L PBTK NA 50% Rat Human -DTXSID2048793 Css NA 0.06363 mg/L PBTK NA 95% Rat Human -DTXSID2048795 Clint NA 0.6949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048795 Fup NA 0.0397 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048795 Vd NA 1.487 L/kg 1compartment NA NA Human Human -DTXSID2048795 Days.Css NA 27 Days PBTK NA NA Human Human -DTXSID2048795 TK.Half.Life NA 135.9 hours 1compartment NA NA Human Human -DTXSID2048795 Css NA 14.48 mg/L 3compartmentss NA 50% Human Human -DTXSID2048795 Css NA 79.02 mg/L 3compartmentss NA 95% Human Human -DTXSID2048795 Css NA 9.228 mg/L PBTK NA 50% Human Human -DTXSID2048795 Css NA 46.83 mg/L PBTK NA 95% Human Human -DTXSID2048795 Clint NA 0.6949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048795 Fup NA 0.0397 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048795 Vd NA 1.11 L/kg 1compartment NA NA Rat Human -DTXSID2048795 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID2048795 TK.Half.Life NA 38.9 hours 1compartment NA NA Rat Human -DTXSID2048795 Css NA 5.957 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048795 Css NA 26.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048795 Css NA 3.552 mg/L PBTK NA 50% Rat Human -DTXSID2048795 Css NA 14.75 mg/L PBTK NA 95% Rat Human -DTXSID2048797 Clint NA 34.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048797 Fup NA 0.6884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048797 Vd NA 4.709 L/kg 1compartment NA NA Human Human -DTXSID2048797 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048797 TK.Half.Life NA 4.016 hours 1compartment NA NA Human Human -DTXSID2048797 Css NA 0.0276 mg/L 3compartmentss NA 50% Human Human -DTXSID2048797 Css NA 0.2009 mg/L 3compartmentss NA 95% Human Human -DTXSID2048797 Css NA 0.02827 mg/L PBTK NA 50% Human Human -DTXSID2048797 Css NA 0.186 mg/L PBTK NA 95% Human Human -DTXSID2048797 Clint NA 34.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048797 Fup NA 0.6884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048797 Vd NA 4.117 L/kg 1compartment NA NA Rat Human -DTXSID2048797 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048797 TK.Half.Life NA 1.204 hours 1compartment NA NA Rat Human -DTXSID2048797 Css NA 0.01481 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048797 Css NA 0.09145 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048797 Css NA 0.01511 mg/L PBTK NA 50% Rat Human -DTXSID2048797 Css NA 0.08222 mg/L PBTK NA 95% Rat Human -DTXSID2048799 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048799 Fup NA 0.4275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048799 Vd NA 0.6317 L/kg 1compartment NA NA Human Human -DTXSID2048799 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2048799 TK.Half.Life NA 9.583 hours 1compartment NA NA Human Human -DTXSID2048799 Css NA 1.689 mg/L 3compartmentss NA 50% Human Human -DTXSID2048799 Css NA 7.631 mg/L 3compartmentss NA 95% Human Human -DTXSID2048799 Css NA 1.272 mg/L PBTK NA 50% Human Human -DTXSID2048799 Css NA 4.883 mg/L PBTK NA 95% Human Human -DTXSID2048799 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048799 Fup NA 0.4275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048799 Vd NA 0.638 L/kg 1compartment NA NA Rat Human +DTXSID2048793 TK.Half.Life NA 1.492 hours 1compartment NA NA Rat Human +DTXSID2048793 Css NA 0.03343 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048793 Css NA 0.1476 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048793 Css NA 0.0241 mg/L PBTK NA 50% Rat Human +DTXSID2048793 Css NA 0.09493 mg/L PBTK NA 95% Rat Human +DTXSID2048795 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048795 Fup 0.0654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048795 Vd NA 0.9065 L/kg 1compartment NA NA Human Human +DTXSID2048795 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048795 TK.Half.Life NA 3.208 hours 1compartment NA NA Human Human +DTXSID2048795 Css NA 0.4285 mg/L 3compartmentss NA 50% Human Human +DTXSID2048795 Css NA 3.268 mg/L 3compartmentss NA 95% Human Human +DTXSID2048795 Css NA 0.2691 mg/L PBTK NA 50% Human Human +DTXSID2048795 Css NA 1.983 mg/L PBTK NA 95% Human Human +DTXSID2048795 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048795 Fup 0.0654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048795 Vd NA 0.6992 L/kg 1compartment NA NA Rat Human +DTXSID2048795 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048795 TK.Half.Life NA 1.422 hours 1compartment NA NA Rat Human +DTXSID2048795 Css NA 0.05676 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048795 Css NA 0.3267 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048795 Css NA 0.0346 mg/L PBTK NA 50% Rat Human +DTXSID2048795 Css NA 0.1941 mg/L PBTK NA 95% Rat Human +DTXSID2048799 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048799 Fup 0.629 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048799 Vd NA 0.7941 L/kg 1compartment NA NA Human Human +DTXSID2048799 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048799 TK.Half.Life NA 8.194 hours 1compartment NA NA Human Human +DTXSID2048799 Css NA 0.6274 mg/L 3compartmentss NA 50% Human Human +DTXSID2048799 Css NA 4.314 mg/L 3compartmentss NA 95% Human Human +DTXSID2048799 Css NA 0.5165 mg/L PBTK NA 50% Human Human +DTXSID2048799 Css NA 2.762 mg/L PBTK NA 95% Human Human +DTXSID2048799 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048799 Fup 0.629 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048799 Vd NA 0.8042 L/kg 1compartment NA NA Rat Human DTXSID2048799 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048799 TK.Half.Life NA 3.293 hours 1compartment NA NA Rat Human -DTXSID2048799 Css NA 0.4572 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048799 Css NA 1.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048799 Css NA 0.3281 mg/L PBTK NA 50% Rat Human -DTXSID2048799 Css NA 1.043 mg/L PBTK NA 95% Rat Human -DTXSID2048820 Clint NA 0.1051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048820 Fup NA 0.1775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048820 Vd NA 1.006 L/kg 1compartment NA NA Human Human -DTXSID2048820 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID2048820 TK.Half.Life NA 32.9 hours 1compartment NA NA Human Human -DTXSID2048820 Css NA 3.741 mg/L 3compartmentss NA 50% Human Human -DTXSID2048820 Css NA 14.12 mg/L 3compartmentss NA 95% Human Human -DTXSID2048820 Css NA 2.632 mg/L PBTK NA 50% Human Human -DTXSID2048820 Css NA 8.809 mg/L PBTK NA 95% Human Human -DTXSID2048820 Clint NA 0.1051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048820 Fup NA 0.1775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048820 Vd NA 0.8999 L/kg 1compartment NA NA Rat Human -DTXSID2048820 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2048820 TK.Half.Life NA 10.42 hours 1compartment NA NA Rat Human -DTXSID2048820 Css NA 1.134 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048820 Css NA 3.543 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048820 Css NA 0.7626 mg/L PBTK NA 50% Rat Human -DTXSID2048820 Css NA 2.085 mg/L PBTK NA 95% Rat Human -DTXSID2048822 Clint NA 0.417 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048822 Fup NA 0.1287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048822 Vd NA 0.3218 L/kg 1compartment NA NA Human Human -DTXSID2048822 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2048822 TK.Half.Life NA 9.561 hours 1compartment NA NA Human Human -DTXSID2048822 Css NA 4.4 mg/L 3compartmentss NA 50% Human Human -DTXSID2048822 Css NA 21.25 mg/L 3compartmentss NA 95% Human Human -DTXSID2048822 Css NA 2.786 mg/L PBTK NA 50% Human Human -DTXSID2048822 Css NA 12.57 mg/L PBTK NA 95% Human Human -DTXSID2048822 Clint NA 0.417 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048822 Fup NA 0.1287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048822 Vd NA 0.3219 L/kg 1compartment NA NA Rat Human +DTXSID2048799 TK.Half.Life NA 2.821 hours 1compartment NA NA Rat Human +DTXSID2048799 Css NA 0.003308 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048799 Css NA 0.02387 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048799 Css NA 0.002613 mg/L PBTK NA 50% Rat Human +DTXSID2048799 Css NA 0.01464 mg/L PBTK NA 95% Rat Human +DTXSID2048820 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048820 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048820 Vd NA 1.134 L/kg 1compartment NA NA Human Human +DTXSID2048820 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048820 TK.Half.Life NA 3.533 hours 1compartment NA NA Human Human +DTXSID2048820 Css NA 0.2832 mg/L 3compartmentss NA 50% Human Human +DTXSID2048820 Css NA 1.787 mg/L 3compartmentss NA 95% Human Human +DTXSID2048820 Css NA 0.207 mg/L PBTK NA 50% Human Human +DTXSID2048820 Css NA 1.175 mg/L PBTK NA 95% Human Human +DTXSID2048820 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048820 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048820 Vd NA 0.934 L/kg 1compartment NA NA Rat Human +DTXSID2048820 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048820 TK.Half.Life NA 1.567 hours 1compartment NA NA Rat Human +DTXSID2048820 Css NA 0.03416 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048820 Css NA 0.1491 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048820 Css NA 0.02461 mg/L PBTK NA 50% Rat Human +DTXSID2048820 Css NA 0.09674 mg/L PBTK NA 95% Rat Human +DTXSID2048822 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048822 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048822 Vd NA 0.5057 L/kg 1compartment NA NA Human Human +DTXSID2048822 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048822 TK.Half.Life NA 1.179 hours 1compartment NA NA Human Human +DTXSID2048822 Css NA 0.1955 mg/L 3compartmentss NA 50% Human Human +DTXSID2048822 Css NA 1.283 mg/L 3compartmentss NA 95% Human Human +DTXSID2048822 Css NA 0.1424 mg/L PBTK NA 50% Human Human +DTXSID2048822 Css NA 0.8454 mg/L PBTK NA 95% Human Human +DTXSID2048822 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048822 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048822 Vd NA 0.51 L/kg 1compartment NA NA Rat Human DTXSID2048822 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048822 TK.Half.Life NA 4.123 hours 1compartment NA NA Rat Human -DTXSID2048822 Css NA 1.589 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048822 Css NA 6.495 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048822 Css NA 0.9412 mg/L PBTK NA 50% Rat Human -DTXSID2048822 Css NA 3.601 mg/L PBTK NA 95% Rat Human -DTXSID2048826 Clint NA 0.5883 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048826 Fup NA 0.1004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048826 Vd NA 0.4799 L/kg 1compartment NA NA Human Human -DTXSID2048826 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2048826 TK.Half.Life NA 15.85 hours 1compartment NA NA Human Human -DTXSID2048826 Css NA 5.076 mg/L 3compartmentss NA 50% Human Human -DTXSID2048826 Css NA 25.02 mg/L 3compartmentss NA 95% Human Human -DTXSID2048826 Css NA 3.171 mg/L PBTK NA 50% Human Human -DTXSID2048826 Css NA 14.71 mg/L PBTK NA 95% Human Human -DTXSID2048826 Clint NA 0.5883 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048826 Fup NA 0.1004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048826 Vd NA 0.4092 L/kg 1compartment NA NA Rat Human +DTXSID2048822 TK.Half.Life NA 0.6762 hours 1compartment NA NA Rat Human +DTXSID2048822 Css NA 0.02309 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048822 Css NA 0.1102 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048822 Css NA 0.01661 mg/L PBTK NA 50% Rat Human +DTXSID2048822 Css NA 0.06981 mg/L PBTK NA 95% Rat Human +DTXSID2048826 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048826 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048826 Vd NA 0.5579 L/kg 1compartment NA NA Human Human +DTXSID2048826 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048826 TK.Half.Life NA 2.704 hours 1compartment NA NA Human Human +DTXSID2048826 Css NA 0.6222 mg/L 3compartmentss NA 50% Human Human +DTXSID2048826 Css NA 4.253 mg/L 3compartmentss NA 95% Human Human +DTXSID2048826 Css NA 0.3963 mg/L PBTK NA 50% Human Human +DTXSID2048826 Css NA 2.582 mg/L PBTK NA 95% Human Human +DTXSID2048826 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048826 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048826 Vd NA 0.4756 L/kg 1compartment NA NA Rat Human DTXSID2048826 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048826 TK.Half.Life NA 6.08 hours 1compartment NA NA Rat Human -DTXSID2048826 Css NA 1.95 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048826 Css NA 8.052 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048826 Css NA 1.138 mg/L PBTK NA 50% Rat Human -DTXSID2048826 Css NA 4.443 mg/L PBTK NA 95% Rat Human -DTXSID2048828 Clint NA 2.114 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048828 Fup NA 0.1795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048828 Vd NA 1.058 L/kg 1compartment NA NA Human Human +DTXSID2048826 TK.Half.Life NA 1.359 hours 1compartment NA NA Rat Human +DTXSID2048826 Css NA 0.0758 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048826 Css NA 0.4 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048826 Css NA 0.04736 mg/L PBTK NA 50% Rat Human +DTXSID2048826 Css NA 0.2348 mg/L PBTK NA 95% Rat Human +DTXSID2048828 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048828 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048828 Vd NA 1.398 L/kg 1compartment NA NA Human Human DTXSID2048828 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048828 TK.Half.Life NA 9.463 hours 1compartment NA NA Human Human -DTXSID2048828 Css NA 1.029 mg/L 3compartmentss NA 50% Human Human -DTXSID2048828 Css NA 4.951 mg/L 3compartmentss NA 95% Human Human -DTXSID2048828 Css NA 0.7284 mg/L PBTK NA 50% Human Human -DTXSID2048828 Css NA 3.164 mg/L PBTK NA 95% Human Human -DTXSID2048828 Clint NA 2.114 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048828 Fup NA 0.1795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048828 Vd NA 0.8882 L/kg 1compartment NA NA Rat Human +DTXSID2048828 TK.Half.Life NA 3.58 hours 1compartment NA NA Human Human +DTXSID2048828 Css NA 0.2158 mg/L 3compartmentss NA 50% Human Human +DTXSID2048828 Css NA 1.374 mg/L 3compartmentss NA 95% Human Human +DTXSID2048828 Css NA 0.1676 mg/L PBTK NA 50% Human Human +DTXSID2048828 Css NA 0.966 mg/L PBTK NA 95% Human Human +DTXSID2048828 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048828 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048828 Vd NA 1.19 L/kg 1compartment NA NA Rat Human DTXSID2048828 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048828 TK.Half.Life NA 4.109 hours 1compartment NA NA Rat Human -DTXSID2048828 Css NA 0.4743 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048828 Css NA 1.673 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048828 Css NA 0.3164 mg/L PBTK NA 50% Rat Human -DTXSID2048828 Css NA 0.995 mg/L PBTK NA 95% Rat Human -DTXSID2048870 Clint NA 29.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048870 Fup NA 0.8074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048870 Vd NA 2.286 L/kg 1compartment NA NA Human Human +DTXSID2048828 TK.Half.Life NA 1.598 hours 1compartment NA NA Rat Human +DTXSID2048828 Css NA 0.02514 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048828 Css NA 0.114 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048828 Css NA 0.01953 mg/L PBTK NA 50% Rat Human +DTXSID2048828 Css NA 0.07704 mg/L PBTK NA 95% Rat Human +DTXSID2048870 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048870 Fup 0.37 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048870 Vd NA 1.348 L/kg 1compartment NA NA Human Human DTXSID2048870 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048870 TK.Half.Life NA 1.374 hours 1compartment NA NA Human Human -DTXSID2048870 Css NA 0.01705 mg/L 3compartmentss NA 50% Human Human -DTXSID2048870 Css NA 0.185 mg/L 3compartmentss NA 95% Human Human -DTXSID2048870 Css NA 0.01761 mg/L PBTK NA 50% Human Human -DTXSID2048870 Css NA 0.1483 mg/L PBTK NA 95% Human Human -DTXSID2048870 Clint NA 29.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048870 Fup NA 0.8074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048870 Vd NA 2.321 L/kg 1compartment NA NA Rat Human +DTXSID2048870 TK.Half.Life NA 2.802 hours 1compartment NA NA Human Human +DTXSID2048870 Css NA 0.1553 mg/L 3compartmentss NA 50% Human Human +DTXSID2048870 Css NA 1.066 mg/L 3compartmentss NA 95% Human Human +DTXSID2048870 Css NA 0.129 mg/L PBTK NA 50% Human Human +DTXSID2048870 Css NA 0.7685 mg/L PBTK NA 95% Human Human +DTXSID2048870 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048870 Fup 0.37 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048870 Vd NA 1.356 L/kg 1compartment NA NA Rat Human DTXSID2048870 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048870 TK.Half.Life NA 0.6796 hours 1compartment NA NA Rat Human -DTXSID2048870 Css NA 0.00858 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048870 Css NA 0.09005 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048870 Css NA 0.00888 mg/L PBTK NA 50% Rat Human -DTXSID2048870 Css NA 0.06665 mg/L PBTK NA 95% Rat Human -DTXSID2048872 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048872 Fup NA 0.2169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048872 Vd NA 3.709 L/kg 1compartment NA NA Human Human +DTXSID2048870 TK.Half.Life NA 1.606 hours 1compartment NA NA Rat Human +DTXSID2048870 Css NA 0.0178 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048870 Css NA 0.09475 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048870 Css NA 0.01505 mg/L PBTK NA 50% Rat Human +DTXSID2048870 Css NA 0.06465 mg/L PBTK NA 95% Rat Human +DTXSID2048872 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048872 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048872 Vd NA 2.366 L/kg 1compartment NA NA Human Human DTXSID2048872 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048872 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human -DTXSID2048872 Css NA 0.08586 mg/L 3compartmentss NA 50% Human Human -DTXSID2048872 Css NA 0.6371 mg/L 3compartmentss NA 95% Human Human -DTXSID2048872 Css NA 0.1026 mg/L PBTK NA 50% Human Human -DTXSID2048872 Css NA 0.6103 mg/L PBTK NA 95% Human Human -DTXSID2048872 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048872 Fup NA 0.2169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048872 Vd NA 3.741 L/kg 1compartment NA NA Rat Human +DTXSID2048872 TK.Half.Life NA 5.914 hours 1compartment NA NA Human Human +DTXSID2048872 Css NA 0.1747 mg/L 3compartmentss NA 50% Human Human +DTXSID2048872 Css NA 1.231 mg/L 3compartmentss NA 95% Human Human +DTXSID2048872 Css NA 0.1703 mg/L PBTK NA 50% Human Human +DTXSID2048872 Css NA 0.9682 mg/L PBTK NA 95% Human Human +DTXSID2048872 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048872 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048872 Vd NA 2.38 L/kg 1compartment NA NA Rat Human DTXSID2048872 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048872 TK.Half.Life NA 3.42 hours 1compartment NA NA Rat Human -DTXSID2048872 Css NA 0.04369 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048872 Css NA 0.2719 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048872 Css NA 0.0522 mg/L PBTK NA 50% Rat Human -DTXSID2048872 Css NA 0.2446 mg/L PBTK NA 95% Rat Human -DTXSID2048874 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048874 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048874 Vd NA 1.183 L/kg 1compartment NA NA Human Human -DTXSID2048874 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2048874 TK.Half.Life NA 32.25 hours 1compartment NA NA Human Human -DTXSID2048874 Css NA 3.038 mg/L 3compartmentss NA 50% Human Human -DTXSID2048874 Css NA 11.41 mg/L 3compartmentss NA 95% Human Human -DTXSID2048874 Css NA 2.234 mg/L PBTK NA 50% Human Human -DTXSID2048874 Css NA 7.381 mg/L PBTK NA 95% Human Human -DTXSID2048874 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048874 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048874 Vd NA 0.9744 L/kg 1compartment NA NA Rat Human +DTXSID2048872 TK.Half.Life NA 3.527 hours 1compartment NA NA Rat Human +DTXSID2048872 Css NA 0.0203 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048872 Css NA 0.1114 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048872 Css NA 0.02015 mg/L PBTK NA 50% Rat Human +DTXSID2048872 Css NA 0.08427 mg/L PBTK NA 95% Rat Human +DTXSID2048874 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048874 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048874 Vd NA 1.59 L/kg 1compartment NA NA Human Human +DTXSID2048874 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2048874 TK.Half.Life NA 27.01 hours 1compartment NA NA Human Human +DTXSID2048874 Css NA 1.668 mg/L 3compartmentss NA 50% Human Human +DTXSID2048874 Css NA 7.853 mg/L 3compartmentss NA 95% Human Human +DTXSID2048874 Css NA 1.386 mg/L PBTK NA 50% Human Human +DTXSID2048874 Css NA 5.242 mg/L PBTK NA 95% Human Human +DTXSID2048874 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048874 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048874 Vd NA 1.319 L/kg 1compartment NA NA Rat Human DTXSID2048874 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048874 TK.Half.Life NA 8.11 hours 1compartment NA NA Rat Human -DTXSID2048874 Css NA 0.8317 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048874 Css NA 2.632 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048874 Css NA 0.5867 mg/L PBTK NA 50% Rat Human -DTXSID2048874 Css NA 1.582 mg/L PBTK NA 95% Rat Human -DTXSID2048876 Clint NA 8.139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048876 Fup NA 0.3704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048876 Vd NA 3.005 L/kg 1compartment NA NA Human Human +DTXSID2048874 TK.Half.Life NA 6.359 hours 1compartment NA NA Rat Human +DTXSID2048874 Css NA 0.1044 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048874 Css NA 0.4266 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048874 Css NA 0.08666 mg/L PBTK NA 50% Rat Human +DTXSID2048874 Css NA 0.2749 mg/L PBTK NA 95% Rat Human +DTXSID2048876 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048876 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048876 Vd NA 1.768 L/kg 1compartment NA NA Human Human DTXSID2048876 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048876 TK.Half.Life NA 4.652 hours 1compartment NA NA Human Human -DTXSID2048876 Css NA 0.09042 mg/L 3compartmentss NA 50% Human Human -DTXSID2048876 Css NA 0.696 mg/L 3compartmentss NA 95% Human Human -DTXSID2048876 Css NA 0.1005 mg/L PBTK NA 50% Human Human -DTXSID2048876 Css NA 0.5959 mg/L PBTK NA 95% Human Human -DTXSID2048876 Clint NA 8.139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048876 Fup NA 0.3704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048876 Vd NA 3.046 L/kg 1compartment NA NA Rat Human +DTXSID2048876 TK.Half.Life NA 3.089 hours 1compartment NA NA Human Human +DTXSID2048876 Css NA 0.1175 mg/L 3compartmentss NA 50% Human Human +DTXSID2048876 Css NA 0.913 mg/L 3compartmentss NA 95% Human Human +DTXSID2048876 Css NA 0.109 mg/L PBTK NA 50% Human Human +DTXSID2048876 Css NA 0.678 mg/L PBTK NA 95% Human Human +DTXSID2048876 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048876 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048876 Vd NA 1.78 L/kg 1compartment NA NA Rat Human DTXSID2048876 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048876 TK.Half.Life NA 2.738 hours 1compartment NA NA Rat Human -DTXSID2048876 Css NA 0.04526 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048876 Css NA 0.2766 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048876 Css NA 0.05012 mg/L PBTK NA 50% Rat Human -DTXSID2048876 Css NA 0.2257 mg/L PBTK NA 95% Rat Human -DTXSID2048878 Clint NA 129.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048878 Fup NA 0.3364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048878 Vd NA 3.795 L/kg 1compartment NA NA Human Human +DTXSID2048876 TK.Half.Life NA 1.761 hours 1compartment NA NA Rat Human +DTXSID2048876 Css NA 0.01336 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048876 Css NA 0.07987 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048876 Css NA 0.01258 mg/L PBTK NA 50% Rat Human +DTXSID2048876 Css NA 0.05757 mg/L PBTK NA 95% Rat Human +DTXSID2048878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048878 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048878 Vd NA 2.638 L/kg 1compartment NA NA Human Human DTXSID2048878 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048878 TK.Half.Life NA 1.936 hours 1compartment NA NA Human Human -DTXSID2048878 Css NA 0.005946 mg/L 3compartmentss NA 50% Human Human -DTXSID2048878 Css NA 0.05503 mg/L 3compartmentss NA 95% Human Human -DTXSID2048878 Css NA 0.007206 mg/L PBTK NA 50% Human Human -DTXSID2048878 Css NA 0.05269 mg/L PBTK NA 95% Human Human -DTXSID2048878 Clint NA 129.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048878 Fup NA 0.3364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048878 Vd NA 3.84 L/kg 1compartment NA NA Rat Human +DTXSID2048878 TK.Half.Life NA 3.26 hours 1compartment NA NA Human Human +DTXSID2048878 Css NA 0.06151 mg/L 3compartmentss NA 50% Human Human +DTXSID2048878 Css NA 0.4677 mg/L 3compartmentss NA 95% Human Human +DTXSID2048878 Css NA 0.06034 mg/L PBTK NA 50% Human Human +DTXSID2048878 Css NA 0.3939 mg/L PBTK NA 95% Human Human +DTXSID2048878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048878 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048878 Vd NA 2.654 L/kg 1compartment NA NA Rat Human DTXSID2048878 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048878 TK.Half.Life NA 0.9198 hours 1compartment NA NA Rat Human -DTXSID2048878 Css NA 0.003102 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048878 Css NA 0.02367 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048878 Css NA 0.003797 mg/L PBTK NA 50% Rat Human -DTXSID2048878 Css NA 0.02195 mg/L PBTK NA 95% Rat Human -DTXSID2048901 Clint NA 16.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048901 Fup NA 0.4286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048901 Vd NA 3.065 L/kg 1compartment NA NA Human Human +DTXSID2048878 TK.Half.Life NA 1.845 hours 1compartment NA NA Rat Human +DTXSID2048878 Css NA 0.007425 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048878 Css NA 0.04754 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048878 Css NA 0.007477 mg/L PBTK NA 50% Rat Human +DTXSID2048878 Css NA 0.03865 mg/L PBTK NA 95% Rat Human +DTXSID2048901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048901 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048901 Vd NA 2.542 L/kg 1compartment NA NA Human Human DTXSID2048901 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048901 TK.Half.Life NA 2.625 hours 1compartment NA NA Human Human -DTXSID2048901 Css NA 0.03338 mg/L 3compartmentss NA 50% Human Human -DTXSID2048901 Css NA 0.3231 mg/L 3compartmentss NA 95% Human Human -DTXSID2048901 Css NA 0.04106 mg/L PBTK NA 50% Human Human -DTXSID2048901 Css NA 0.2939 mg/L PBTK NA 95% Human Human -DTXSID2048901 Clint NA 16.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048901 Fup NA 0.4286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048901 Vd NA 3.054 L/kg 1compartment NA NA Rat Human +DTXSID2048901 TK.Half.Life NA 2.367 hours 1compartment NA NA Human Human +DTXSID2048901 Css NA 0.03553 mg/L 3compartmentss NA 50% Human Human +DTXSID2048901 Css NA 0.3213 mg/L 3compartmentss NA 95% Human Human +DTXSID2048901 Css NA 0.03876 mg/L PBTK NA 50% Human Human +DTXSID2048901 Css NA 0.2818 mg/L PBTK NA 95% Human Human +DTXSID2048901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048901 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048901 Vd NA 2.524 L/kg 1compartment NA NA Rat Human DTXSID2048901 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048901 TK.Half.Life NA 1.448 hours 1compartment NA NA Rat Human -DTXSID2048901 Css NA 0.0171 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048901 Css NA 0.1323 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048901 Css NA 0.02138 mg/L PBTK NA 50% Rat Human -DTXSID2048901 Css NA 0.1148 mg/L PBTK NA 95% Rat Human -DTXSID2048903 Clint NA 16.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048903 Fup NA 0.3861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048903 Vd NA 3.106 L/kg 1compartment NA NA Human Human +DTXSID2048901 TK.Half.Life NA 1.292 hours 1compartment NA NA Rat Human +DTXSID2048901 Css NA 0.004313 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048901 Css NA 0.03142 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048901 Css NA 0.004878 mg/L PBTK NA 50% Rat Human +DTXSID2048901 Css NA 0.02703 mg/L PBTK NA 95% Rat Human +DTXSID2048903 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048903 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048903 Vd NA 3.165 L/kg 1compartment NA NA Human Human DTXSID2048903 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048903 TK.Half.Life NA 3.37 hours 1compartment NA NA Human Human -DTXSID2048903 Css NA 0.05248 mg/L 3compartmentss NA 50% Human Human -DTXSID2048903 Css NA 0.4085 mg/L 3compartmentss NA 95% Human Human -DTXSID2048903 Css NA 0.05564 mg/L PBTK NA 50% Human Human -DTXSID2048903 Css NA 0.3467 mg/L PBTK NA 95% Human Human -DTXSID2048903 Clint NA 16.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048903 Fup NA 0.3861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048903 Vd NA 3.027 L/kg 1compartment NA NA Rat Human +DTXSID2048903 TK.Half.Life NA 7.25 hours 1compartment NA NA Human Human +DTXSID2048903 Css NA 0.1539 mg/L 3compartmentss NA 50% Human Human +DTXSID2048903 Css NA 1.03 mg/L 3compartmentss NA 95% Human Human +DTXSID2048903 Css NA 0.1595 mg/L PBTK NA 50% Human Human +DTXSID2048903 Css NA 0.8846 mg/L PBTK NA 95% Human Human +DTXSID2048903 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048903 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048903 Vd NA 3.033 L/kg 1compartment NA NA Rat Human DTXSID2048903 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048903 TK.Half.Life NA 1.706 hours 1compartment NA NA Rat Human -DTXSID2048903 Css NA 0.02696 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048903 Css NA 0.168 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048903 Css NA 0.02831 mg/L PBTK NA 50% Rat Human -DTXSID2048903 Css NA 0.1397 mg/L PBTK NA 95% Rat Human +DTXSID2048903 TK.Half.Life NA 3.588 hours 1compartment NA NA Rat Human +DTXSID2048903 Css NA 0.01766 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048903 Css NA 0.09202 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048903 Css NA 0.01876 mg/L PBTK NA 50% Rat Human +DTXSID2048903 Css NA 0.07556 mg/L PBTK NA 95% Rat Human DTXSID2048905 Clint NA 10.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2048905 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048905 Vd NA 3.084 L/kg 1compartment NA NA Human Human -DTXSID2048905 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2048905 TK.Half.Life NA 26.13 hours 1compartment NA NA Human Human -DTXSID2048905 Css NA 1.036 mg/L 3compartmentss NA 50% Human Human -DTXSID2048905 Css NA 6.787 mg/L 3compartmentss NA 95% Human Human -DTXSID2048905 Css NA 0.7413 mg/L PBTK NA 50% Human Human -DTXSID2048905 Css NA 4.62 mg/L PBTK NA 95% Human Human +DTXSID2048905 Vd NA 2.872 L/kg 1compartment NA NA Human Human +DTXSID2048905 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID2048905 TK.Half.Life NA 66.65 hours 1compartment NA NA Human Human +DTXSID2048905 Css NA 3.009 mg/L 3compartmentss NA 50% Human Human +DTXSID2048905 Css NA 19.54 mg/L 3compartmentss NA 95% Human Human +DTXSID2048905 Css NA 2.044 mg/L PBTK NA 50% Human Human +DTXSID2048905 Css NA 12.92 mg/L PBTK NA 95% Human Human DTXSID2048905 Clint NA 10.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2048905 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048905 Vd NA 2.407 L/kg 1compartment NA NA Rat Human -DTXSID2048905 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2048905 TK.Half.Life NA 5.501 hours 1compartment NA NA Rat Human -DTXSID2048905 Css NA 0.5694 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048905 Css NA 3.152 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048905 Css NA 0.3913 mg/L PBTK NA 50% Rat Human -DTXSID2048905 Css NA 2.091 mg/L PBTK NA 95% Rat Human -DTXSID2048907 Clint NA 22.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048907 Fup NA 0.4077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048907 Vd NA 2.751 L/kg 1compartment NA NA Human Human +DTXSID2048905 Vd NA 2.152 L/kg 1compartment NA NA Rat Human +DTXSID2048905 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID2048905 TK.Half.Life NA 11.99 hours 1compartment NA NA Rat Human +DTXSID2048905 Css NA 0.3852 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048905 Css NA 1.984 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048905 Css NA 0.2591 mg/L PBTK NA 50% Rat Human +DTXSID2048905 Css NA 1.298 mg/L PBTK NA 95% Rat Human +DTXSID2048907 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048907 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048907 Vd NA 3.031 L/kg 1compartment NA NA Human Human DTXSID2048907 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048907 TK.Half.Life NA 2.378 hours 1compartment NA NA Human Human -DTXSID2048907 Css NA 0.03384 mg/L 3compartmentss NA 50% Human Human -DTXSID2048907 Css NA 0.2812 mg/L 3compartmentss NA 95% Human Human -DTXSID2048907 Css NA 0.03607 mg/L PBTK NA 50% Human Human -DTXSID2048907 Css NA 0.2371 mg/L PBTK NA 95% Human Human -DTXSID2048907 Clint NA 22.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048907 Fup NA 0.4077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048907 Vd NA 2.787 L/kg 1compartment NA NA Rat Human +DTXSID2048907 TK.Half.Life NA 4.032 hours 1compartment NA NA Human Human +DTXSID2048907 Css NA 0.07775 mg/L 3compartmentss NA 50% Human Human +DTXSID2048907 Css NA 0.9012 mg/L 3compartmentss NA 95% Human Human +DTXSID2048907 Css NA 0.08908 mg/L PBTK NA 50% Human Human +DTXSID2048907 Css NA 0.6941 mg/L PBTK NA 95% Human Human +DTXSID2048907 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048907 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048907 Vd NA 3.08 L/kg 1compartment NA NA Rat Human DTXSID2048907 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048907 TK.Half.Life NA 1.292 hours 1compartment NA NA Rat Human -DTXSID2048907 Css NA 0.01726 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048907 Css NA 0.1226 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048907 Css NA 0.01841 mg/L PBTK NA 50% Rat Human -DTXSID2048907 Css NA 0.09976 mg/L PBTK NA 95% Rat Human -DTXSID2048909 Clint NA 6.511 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048909 Fup NA 0.3186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048909 Vd NA 2.179 L/kg 1compartment NA NA Human Human +DTXSID2048907 TK.Half.Life NA 2.317 hours 1compartment NA NA Rat Human +DTXSID2048907 Css NA 0.008581 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048907 Css NA 0.08812 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048907 Css NA 0.01033 mg/L PBTK NA 50% Rat Human +DTXSID2048907 Css NA 0.06364 mg/L PBTK NA 95% Rat Human +DTXSID2048909 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048909 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048909 Vd NA 3.987 L/kg 1compartment NA NA Human Human DTXSID2048909 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048909 TK.Half.Life NA 4.702 hours 1compartment NA NA Human Human -DTXSID2048909 Css NA 0.1557 mg/L 3compartmentss NA 50% Human Human -DTXSID2048909 Css NA 1.095 mg/L 3compartmentss NA 95% Human Human -DTXSID2048909 Css NA 0.1474 mg/L PBTK NA 50% Human Human -DTXSID2048909 Css NA 0.8485 mg/L PBTK NA 95% Human Human -DTXSID2048909 Clint NA 6.511 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048909 Fup NA 0.3186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048909 Vd NA 2.195 L/kg 1compartment NA NA Rat Human +DTXSID2048909 TK.Half.Life NA 4.854 hours 1compartment NA NA Human Human +DTXSID2048909 Css NA 0.0655 mg/L 3compartmentss NA 50% Human Human +DTXSID2048909 Css NA 0.7337 mg/L 3compartmentss NA 95% Human Human +DTXSID2048909 Css NA 0.08596 mg/L PBTK NA 50% Human Human +DTXSID2048909 Css NA 0.6292 mg/L PBTK NA 95% Human Human +DTXSID2048909 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048909 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048909 Vd NA 4.058 L/kg 1compartment NA NA Rat Human DTXSID2048909 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048909 TK.Half.Life NA 2.751 hours 1compartment NA NA Rat Human -DTXSID2048909 Css NA 0.07722 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048909 Css NA 0.4186 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048909 Css NA 0.07151 mg/L PBTK NA 50% Rat Human -DTXSID2048909 Css NA 0.3107 mg/L PBTK NA 95% Rat Human -DTXSID2048953 Clint NA 22.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048953 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048953 Vd NA 0.3921 L/kg 1compartment NA NA Human Human +DTXSID2048909 TK.Half.Life NA 2.757 hours 1compartment NA NA Rat Human +DTXSID2048909 Css NA 0.006971 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048909 Css NA 0.07665 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048909 Css NA 0.009693 mg/L PBTK NA 50% Rat Human +DTXSID2048909 Css NA 0.05923 mg/L PBTK NA 95% Rat Human +DTXSID2048953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048953 Fup 0.0257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048953 Vd NA 0.7129 L/kg 1compartment NA NA Human Human DTXSID2048953 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048953 TK.Half.Life NA 3.675 hours 1compartment NA NA Human Human -DTXSID2048953 Css NA 1.568 mg/L 3compartmentss NA 50% Human Human -DTXSID2048953 Css NA 15.94 mg/L 3compartmentss NA 95% Human Human -DTXSID2048953 Css NA 0.9662 mg/L PBTK NA 50% Human Human -DTXSID2048953 Css NA 9.496 mg/L PBTK NA 95% Human Human -DTXSID2048953 Clint NA 22.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048953 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048953 Vd NA 0.3497 L/kg 1compartment NA NA Rat Human +DTXSID2048953 TK.Half.Life NA 5.112 hours 1compartment NA NA Human Human +DTXSID2048953 Css NA 0.941 mg/L 3compartmentss NA 50% Human Human +DTXSID2048953 Css NA 9.981 mg/L 3compartmentss NA 95% Human Human +DTXSID2048953 Css NA 0.6048 mg/L PBTK NA 50% Human Human +DTXSID2048953 Css NA 6.097 mg/L PBTK NA 95% Human Human +DTXSID2048953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048953 Fup 0.0257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048953 Vd NA 0.5952 L/kg 1compartment NA NA Rat Human DTXSID2048953 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048953 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human -DTXSID2048953 Css NA 0.8818 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048953 Css NA 7.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048953 Css NA 0.5052 mg/L PBTK NA 50% Rat Human -DTXSID2048953 Css NA 4.028 mg/L PBTK NA 95% Rat Human -DTXSID2048955 Clint NA 1.959 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048955 Fup NA 0.0802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048955 Vd NA 1.088 L/kg 1compartment NA NA Human Human -DTXSID2048955 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2048955 TK.Half.Life NA 22.54 hours 1compartment NA NA Human Human -DTXSID2048955 Css NA 3.201 mg/L 3compartmentss NA 50% Human Human -DTXSID2048955 Css NA 17.05 mg/L 3compartmentss NA 95% Human Human -DTXSID2048955 Css NA 2.066 mg/L PBTK NA 50% Human Human -DTXSID2048955 Css NA 10.29 mg/L PBTK NA 95% Human Human -DTXSID2048955 Clint NA 1.959 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048955 Fup NA 0.0802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048955 Vd NA 0.8508 L/kg 1compartment NA NA Rat Human -DTXSID2048955 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2048955 TK.Half.Life NA 8.865 hours 1compartment NA NA Rat Human -DTXSID2048955 Css NA 1.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048955 Css NA 6.306 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048955 Css NA 0.9092 mg/L PBTK NA 50% Rat Human -DTXSID2048955 Css NA 3.55 mg/L PBTK NA 95% Rat Human +DTXSID2048953 TK.Half.Life NA 2.68 hours 1compartment NA NA Rat Human +DTXSID2048953 Css NA 0.04599 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048953 Css NA 0.4963 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048953 Css NA 0.02897 mg/L PBTK NA 50% Rat Human +DTXSID2048953 Css NA 0.2961 mg/L PBTK NA 95% Rat Human +DTXSID2048955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048955 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048955 Vd NA 1.354 L/kg 1compartment NA NA Human Human +DTXSID2048955 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2048955 TK.Half.Life NA 3.2 hours 1compartment NA NA Human Human +DTXSID2048955 Css NA 0.2284 mg/L 3compartmentss NA 50% Human Human +DTXSID2048955 Css NA 1.804 mg/L 3compartmentss NA 95% Human Human +DTXSID2048955 Css NA 0.1546 mg/L PBTK NA 50% Human Human +DTXSID2048955 Css NA 1.132 mg/L PBTK NA 95% Human Human +DTXSID2048955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048955 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048955 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID2048955 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2048955 TK.Half.Life NA 1.312 hours 1compartment NA NA Rat Human +DTXSID2048955 Css NA 0.03003 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048955 Css NA 0.1769 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048955 Css NA 0.0198 mg/L PBTK NA 50% Rat Human +DTXSID2048955 Css NA 0.11 mg/L PBTK NA 95% Rat Human DTXSID2048957 Clint 42.66 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID2048957 Fup NA 0.0067 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048957 Vd NA 14.66 L/kg 1compartment NA NA Human Human -DTXSID2048957 Days.Css NA 44 Days PBTK NA NA Human Human -DTXSID2048957 TK.Half.Life NA 226.9 hours 1compartment NA NA Human Human -DTXSID2048957 Css NA 0.787 mg/L 3compartmentss NA 50% Human Human -DTXSID2048957 Css NA 4.372 mg/L 3compartmentss NA 95% Human Human -DTXSID2048957 Css NA 1.257 mg/L PBTK NA 50% Human Human -DTXSID2048957 Css NA 6.817 mg/L PBTK NA 95% Human Human +DTXSID2048957 Fup 0.039 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048957 Vd NA 13.64 L/kg 1compartment NA NA Human Human +DTXSID2048957 Days.Css NA 39 Days PBTK NA NA Human Human +DTXSID2048957 TK.Half.Life NA 207.9 hours 1compartment NA NA Human Human +DTXSID2048957 Css NA 0.7776 mg/L 3compartmentss NA 50% Human Human +DTXSID2048957 Css NA 4.919 mg/L 3compartmentss NA 95% Human Human +DTXSID2048957 Css NA 1.172 mg/L PBTK NA 50% Human Human +DTXSID2048957 Css NA 6.97 mg/L PBTK NA 95% Human Human DTXSID2048957 Clint 42.66 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID2048957 Fup NA 0.0067 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048957 Vd NA 11.75 L/kg 1compartment NA NA Rat Human -DTXSID2048957 Days.Css NA 27 Days PBTK NA NA Rat Human -DTXSID2048957 TK.Half.Life NA 33.4 hours 1compartment NA NA Rat Human -DTXSID2048957 Css NA 0.4215 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048957 Css NA 1.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048957 Css NA 0.685 mg/L PBTK NA 50% Rat Human -DTXSID2048957 Css NA 2.777 mg/L PBTK NA 95% Rat Human -DTXSID2048959 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048959 Fup NA 0.8682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2048959 Vd NA 0.5383 L/kg 1compartment NA NA Human Human +DTXSID2048957 Fup 0.039 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048957 Vd NA 10.89 L/kg 1compartment NA NA Rat Human +DTXSID2048957 Days.Css NA 24 Days PBTK NA NA Rat Human +DTXSID2048957 TK.Half.Life NA 29.15 hours 1compartment NA NA Rat Human +DTXSID2048957 Css NA 0.09106 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048957 Css NA 0.4337 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048957 Css NA 0.1459 mg/L PBTK NA 50% Rat Human +DTXSID2048957 Css NA 0.7033 mg/L PBTK NA 95% Rat Human +DTXSID2048959 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048959 Fup 0.911 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2048959 Vd NA 0.5399 L/kg 1compartment NA NA Human Human DTXSID2048959 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2048959 TK.Half.Life NA 4.011 hours 1compartment NA NA Human Human -DTXSID2048959 Css NA 0.9994 mg/L 3compartmentss NA 50% Human Human -DTXSID2048959 Css NA 5.695 mg/L 3compartmentss NA 95% Human Human -DTXSID2048959 Css NA 0.7772 mg/L PBTK NA 50% Human Human -DTXSID2048959 Css NA 3.593 mg/L PBTK NA 95% Human Human -DTXSID2048959 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048959 Fup NA 0.8682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2048959 Vd NA 0.5756 L/kg 1compartment NA NA Rat Human +DTXSID2048959 TK.Half.Life NA 3.834 hours 1compartment NA NA Human Human +DTXSID2048959 Css NA 0.5095 mg/L 3compartmentss NA 50% Human Human +DTXSID2048959 Css NA 1.949 mg/L 3compartmentss NA 95% Human Human +DTXSID2048959 Css NA 0.3981 mg/L PBTK NA 50% Human Human +DTXSID2048959 Css NA 1.324 mg/L PBTK NA 95% Human Human +DTXSID2048959 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048959 Fup 0.911 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2048959 Vd NA 0.5808 L/kg 1compartment NA NA Rat Human DTXSID2048959 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2048959 TK.Half.Life NA 1.462 hours 1compartment NA NA Rat Human -DTXSID2048959 Css NA 0.2589 mg/L 3compartmentss NA 50% Rat Human -DTXSID2048959 Css NA 1.507 mg/L 3compartmentss NA 95% Rat Human -DTXSID2048959 Css NA 0.194 mg/L PBTK NA 50% Rat Human -DTXSID2048959 Css NA 0.8831 mg/L PBTK NA 95% Rat Human -DTXSID2049000 Clint NA 3.048 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2048959 TK.Half.Life NA 1.406 hours 1compartment NA NA Rat Human +DTXSID2048959 Css NA 0.002649 mg/L 3compartmentss NA 50% Rat Human +DTXSID2048959 Css NA 0.01112 mg/L 3compartmentss NA 95% Rat Human +DTXSID2048959 Css NA 0.002002 mg/L PBTK NA 50% Rat Human +DTXSID2048959 Css NA 0.007227 mg/L PBTK NA 95% Rat Human +DTXSID2049000 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID2049000 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID2049000 Vd NA 1.039 L/kg 1compartment NA NA Human Human -DTXSID2049000 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID2049000 TK.Half.Life NA 37.15 hours 1compartment NA NA Human Human -DTXSID2049000 Css NA 6.158 mg/L 3compartmentss NA 50% Human Human -DTXSID2049000 Css NA 43.55 mg/L 3compartmentss NA 95% Human Human -DTXSID2049000 Css NA 3.792 mg/L PBTK NA 50% Human Human -DTXSID2049000 Css NA 25.8 mg/L PBTK NA 95% Human Human -DTXSID2049000 Clint NA 3.048 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2049000 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2049000 TK.Half.Life NA 19.93 hours 1compartment NA NA Human Human +DTXSID2049000 Css NA 3.218 mg/L 3compartmentss NA 50% Human Human +DTXSID2049000 Css NA 25.4 mg/L 3compartmentss NA 95% Human Human +DTXSID2049000 Css NA 1.982 mg/L PBTK NA 50% Human Human +DTXSID2049000 Css NA 15.31 mg/L PBTK NA 95% Human Human +DTXSID2049000 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID2049000 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID2049000 Vd NA 0.7805 L/kg 1compartment NA NA Rat Human -DTXSID2049000 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2049000 TK.Half.Life NA 14.95 hours 1compartment NA NA Rat Human -DTXSID2049000 Css NA 3.122 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049000 Css NA 17.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049000 Css NA 1.804 mg/L PBTK NA 50% Rat Human -DTXSID2049000 Css NA 9.752 mg/L PBTK NA 95% Rat Human -DTXSID2049002 Clint NA 2.276 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049002 Fup NA 0.0245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049002 Vd NA 0.251 L/kg 1compartment NA NA Human Human -DTXSID2049002 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2049002 TK.Half.Life NA 14.04 hours 1compartment NA NA Human Human -DTXSID2049002 Css NA 9.997 mg/L 3compartmentss NA 50% Human Human -DTXSID2049002 Css NA 70.35 mg/L 3compartmentss NA 95% Human Human -DTXSID2049002 Css NA 5.978 mg/L PBTK NA 50% Human Human -DTXSID2049002 Css NA 41.61 mg/L PBTK NA 95% Human Human -DTXSID2049002 Clint NA 2.276 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049002 Fup NA 0.0245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049002 Vd NA 0.2445 L/kg 1compartment NA NA Rat Human +DTXSID2049000 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2049000 TK.Half.Life NA 8.48 hours 1compartment NA NA Rat Human +DTXSID2049000 Css NA 0.3994 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049000 Css NA 2.505 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049000 Css NA 0.2392 mg/L PBTK NA 50% Rat Human +DTXSID2049000 Css NA 1.429 mg/L PBTK NA 95% Rat Human +DTXSID2049002 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049002 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049002 Vd NA 0.3139 L/kg 1compartment NA NA Human Human +DTXSID2049002 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2049002 TK.Half.Life NA 1.256 hours 1compartment NA NA Human Human +DTXSID2049002 Css NA 0.2902 mg/L 3compartmentss NA 50% Human Human +DTXSID2049002 Css NA 2.504 mg/L 3compartmentss NA 95% Human Human +DTXSID2049002 Css NA 0.1795 mg/L PBTK NA 50% Human Human +DTXSID2049002 Css NA 1.511 mg/L PBTK NA 95% Human Human +DTXSID2049002 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049002 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049002 Vd NA 0.3077 L/kg 1compartment NA NA Rat Human DTXSID2049002 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049002 TK.Half.Life NA 7.817 hours 1compartment NA NA Rat Human -DTXSID2049002 Css NA 4.728 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049002 Css NA 29.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049002 Css NA 2.644 mg/L PBTK NA 50% Rat Human -DTXSID2049002 Css NA 15.8 mg/L PBTK NA 95% Rat Human -DTXSID2049004 Clint NA 26.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049004 Fup NA 0.0664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049004 Vd NA 2.828 L/kg 1compartment NA NA Human Human +DTXSID2049002 TK.Half.Life NA 0.7689 hours 1compartment NA NA Rat Human +DTXSID2049002 Css NA 0.003126 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049002 Css NA 0.02396 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049002 Css NA 0.001808 mg/L PBTK NA 50% Rat Human +DTXSID2049002 Css NA 0.01347 mg/L PBTK NA 95% Rat Human +DTXSID2049004 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049004 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049004 Vd NA 2.931 L/kg 1compartment NA NA Human Human DTXSID2049004 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2049004 TK.Half.Life NA 20.11 hours 1compartment NA NA Human Human -DTXSID2049004 Css NA 0.8553 mg/L 3compartmentss NA 50% Human Human -DTXSID2049004 Css NA 5.459 mg/L 3compartmentss NA 95% Human Human -DTXSID2049004 Css NA 0.5889 mg/L PBTK NA 50% Human Human -DTXSID2049004 Css NA 3.615 mg/L PBTK NA 95% Human Human -DTXSID2049004 Clint NA 26.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049004 Fup NA 0.0664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049004 Vd NA 2.123 L/kg 1compartment NA NA Rat Human -DTXSID2049004 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2049004 TK.Half.Life NA 4.073 hours 1compartment NA NA Rat Human -DTXSID2049004 Css NA 0.4743 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049004 Css NA 2.377 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049004 Css NA 0.3117 mg/L PBTK NA 50% Rat Human -DTXSID2049004 Css NA 1.511 mg/L PBTK NA 95% Rat Human -DTXSID2049006 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049006 Fup NA 0.1645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049006 Vd NA 0.5437 L/kg 1compartment NA NA Human Human -DTXSID2049006 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049006 TK.Half.Life NA 2.928 hours 1compartment NA NA Human Human -DTXSID2049006 Css NA 0.6586 mg/L 3compartmentss NA 50% Human Human -DTXSID2049006 Css NA 3.713 mg/L 3compartmentss NA 95% Human Human -DTXSID2049006 Css NA 0.4263 mg/L PBTK NA 50% Human Human -DTXSID2049006 Css NA 2.274 mg/L PBTK NA 95% Human Human -DTXSID2049006 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049006 Fup NA 0.1645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049006 Vd NA 0.4735 L/kg 1compartment NA NA Rat Human +DTXSID2049004 TK.Half.Life NA 14.82 hours 1compartment NA NA Human Human +DTXSID2049004 Css NA 0.5088 mg/L 3compartmentss NA 50% Human Human +DTXSID2049004 Css NA 3.108 mg/L 3compartmentss NA 95% Human Human +DTXSID2049004 Css NA 0.3622 mg/L PBTK NA 50% Human Human +DTXSID2049004 Css NA 2.146 mg/L PBTK NA 95% Human Human +DTXSID2049004 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049004 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049004 Vd NA 2.212 L/kg 1compartment NA NA Rat Human +DTXSID2049004 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2049004 TK.Half.Life NA 2.897 hours 1compartment NA NA Rat Human +DTXSID2049004 Css NA 0.06428 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049004 Css NA 0.3107 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049004 Css NA 0.04584 mg/L PBTK NA 50% Rat Human +DTXSID2049004 Css NA 0.2169 mg/L PBTK NA 95% Rat Human +DTXSID2049006 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049006 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049006 Vd NA 0.7564 L/kg 1compartment NA NA Human Human +DTXSID2049006 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2049006 TK.Half.Life NA 15.46 hours 1compartment NA NA Human Human +DTXSID2049006 Css NA 1.978 mg/L 3compartmentss NA 50% Human Human +DTXSID2049006 Css NA 7.994 mg/L 3compartmentss NA 95% Human Human +DTXSID2049006 Css NA 1.436 mg/L PBTK NA 50% Human Human +DTXSID2049006 Css NA 5.087 mg/L PBTK NA 95% Human Human +DTXSID2049006 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049006 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049006 Vd NA 0.6653 L/kg 1compartment NA NA Rat Human DTXSID2049006 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049006 TK.Half.Life NA 1.478 hours 1compartment NA NA Rat Human -DTXSID2049006 Css NA 0.3335 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049006 Css NA 1.378 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049006 Css NA 0.2048 mg/L PBTK NA 50% Rat Human -DTXSID2049006 Css NA 0.7953 mg/L PBTK NA 95% Rat Human -DTXSID2049008 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049008 Fup NA 0.2864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049008 Vd NA 3.05 L/kg 1compartment NA NA Human Human -DTXSID2049008 Days.Css NA 235 Days PBTK NA NA Human Human -DTXSID2049008 TK.Half.Life NA 931.3 hours 1compartment NA NA Human Human -DTXSID2049008 Css NA 31.96 mg/L 3compartmentss NA 50% Human Human -DTXSID2049008 Css NA 92.7 mg/L 3compartmentss NA 95% Human Human -DTXSID2049008 Css NA 24.31 mg/L PBTK NA 50% Human Human -DTXSID2049008 Css NA 63.86 mg/L PBTK NA 95% Human Human -DTXSID2049008 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049008 Fup NA 0.2864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049008 Vd NA 2.319 L/kg 1compartment NA NA Rat Human -DTXSID2049008 Days.Css NA 59 Days PBTK NA NA Rat Human -DTXSID2049008 TK.Half.Life NA 71.12 hours 1compartment NA NA Rat Human -DTXSID2049008 Css NA 8.611 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049008 Css NA 19.72 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049008 Css NA 6.33 mg/L PBTK NA 50% Rat Human -DTXSID2049008 Css NA 12.59 mg/L PBTK NA 95% Rat Human -DTXSID2049050 Clint NA 231.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049050 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049050 Vd NA 2.393 L/kg 1compartment NA NA Human Human +DTXSID2049006 TK.Half.Life NA 4.481 hours 1compartment NA NA Rat Human +DTXSID2049006 Css NA 0.0481 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049006 Css NA 0.2719 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049006 Css NA 0.03434 mg/L PBTK NA 50% Rat Human +DTXSID2049006 Css NA 0.1714 mg/L PBTK NA 95% Rat Human +DTXSID2049050 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049050 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049050 Vd NA 3.033 L/kg 1compartment NA NA Human Human DTXSID2049050 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049050 TK.Half.Life NA 3.597 hours 1compartment NA NA Human Human -DTXSID2049050 Css NA 0.1045 mg/L 3compartmentss NA 50% Human Human -DTXSID2049050 Css NA 0.9099 mg/L 3compartmentss NA 95% Human Human -DTXSID2049050 Css NA 0.07015 mg/L PBTK NA 50% Human Human -DTXSID2049050 Css NA 0.5736 mg/L PBTK NA 95% Human Human -DTXSID2049050 Clint NA 231.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049050 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049050 Vd NA 1.843 L/kg 1compartment NA NA Rat Human +DTXSID2049050 TK.Half.Life NA 12.27 hours 1compartment NA NA Human Human +DTXSID2049050 Css NA 0.3979 mg/L 3compartmentss NA 50% Human Human +DTXSID2049050 Css NA 2.69 mg/L 3compartmentss NA 95% Human Human +DTXSID2049050 Css NA 0.2968 mg/L PBTK NA 50% Human Human +DTXSID2049050 Css NA 1.879 mg/L PBTK NA 95% Human Human +DTXSID2049050 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049050 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049050 Vd NA 2.403 L/kg 1compartment NA NA Rat Human DTXSID2049050 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049050 TK.Half.Life NA 1.157 hours 1compartment NA NA Rat Human -DTXSID2049050 Css NA 0.05872 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049050 Css NA 0.4035 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049050 Css NA 0.03726 mg/L PBTK NA 50% Rat Human -DTXSID2049050 Css NA 0.2472 mg/L PBTK NA 95% Rat Human -DTXSID2049052 Clint NA 78.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049052 Fup NA 0.1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049052 Vd NA 1.171 L/kg 1compartment NA NA Human Human +DTXSID2049050 TK.Half.Life NA 3.023 hours 1compartment NA NA Rat Human +DTXSID2049050 Css NA 0.05002 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049050 Css NA 0.2659 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049050 Css NA 0.03742 mg/L PBTK NA 50% Rat Human +DTXSID2049050 Css NA 0.1891 mg/L PBTK NA 95% Rat Human +DTXSID2049052 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049052 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049052 Vd NA 1.429 L/kg 1compartment NA NA Human Human DTXSID2049052 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049052 TK.Half.Life NA 1.599 hours 1compartment NA NA Human Human -DTXSID2049052 Css NA 0.08534 mg/L 3compartmentss NA 50% Human Human -DTXSID2049052 Css NA 0.6899 mg/L 3compartmentss NA 95% Human Human -DTXSID2049052 Css NA 0.05572 mg/L PBTK NA 50% Human Human -DTXSID2049052 Css NA 0.4238 mg/L PBTK NA 95% Human Human -DTXSID2049052 Clint NA 78.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049052 Fup NA 0.1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049052 Vd NA 0.9124 L/kg 1compartment NA NA Rat Human +DTXSID2049052 TK.Half.Life NA 3.029 hours 1compartment NA NA Human Human +DTXSID2049052 Css NA 0.1853 mg/L 3compartmentss NA 50% Human Human +DTXSID2049052 Css NA 1.378 mg/L 3compartmentss NA 95% Human Human +DTXSID2049052 Css NA 0.127 mg/L PBTK NA 50% Human Human +DTXSID2049052 Css NA 0.8953 mg/L PBTK NA 95% Human Human +DTXSID2049052 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049052 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049052 Vd NA 1.119 L/kg 1compartment NA NA Rat Human DTXSID2049052 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049052 TK.Half.Life NA 0.6205 hours 1compartment NA NA Rat Human -DTXSID2049052 Css NA 0.048 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049052 Css NA 0.3092 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049052 Css NA 0.02965 mg/L PBTK NA 50% Rat Human -DTXSID2049052 Css NA 0.1814 mg/L PBTK NA 95% Rat Human -DTXSID2049054 Clint NA 0.404 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049054 Fup NA 0.0942 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049054 Vd NA 1.183 L/kg 1compartment NA NA Human Human -DTXSID2049054 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID2049054 TK.Half.Life NA 41.68 hours 1compartment NA NA Human Human -DTXSID2049054 Css NA 4.586 mg/L 3compartmentss NA 50% Human Human -DTXSID2049054 Css NA 25.51 mg/L 3compartmentss NA 95% Human Human -DTXSID2049054 Css NA 3.405 mg/L PBTK NA 50% Human Human -DTXSID2049054 Css NA 15.98 mg/L PBTK NA 95% Human Human -DTXSID2049054 Clint NA 0.404 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049054 Fup NA 0.0942 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049054 Vd NA 1.147 L/kg 1compartment NA NA Rat Human -DTXSID2049054 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2049054 TK.Half.Life NA 18.35 hours 1compartment NA NA Rat Human -DTXSID2049054 Css NA 1.738 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049054 Css NA 8.012 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049054 Css NA 1.23 mg/L PBTK NA 50% Rat Human -DTXSID2049054 Css NA 4.705 mg/L PBTK NA 95% Rat Human -DTXSID2049056 Clint NA 3.943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049056 Fup NA 0.5883 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049056 Vd NA 1.577 L/kg 1compartment NA NA Human Human +DTXSID2049052 TK.Half.Life NA 1.207 hours 1compartment NA NA Rat Human +DTXSID2049052 Css NA 0.02381 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049052 Css NA 0.1458 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049052 Css NA 0.01613 mg/L PBTK NA 50% Rat Human +DTXSID2049052 Css NA 0.09116 mg/L PBTK NA 95% Rat Human +DTXSID2049054 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049054 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049054 Vd NA 1.13 L/kg 1compartment NA NA Human Human +DTXSID2049054 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2049054 TK.Half.Life NA 5.303 hours 1compartment NA NA Human Human +DTXSID2049054 Css NA 0.2928 mg/L 3compartmentss NA 50% Human Human +DTXSID2049054 Css NA 2.075 mg/L 3compartmentss NA 95% Human Human +DTXSID2049054 Css NA 0.1973 mg/L PBTK NA 50% Human Human +DTXSID2049054 Css NA 1.299 mg/L PBTK NA 95% Human Human +DTXSID2049054 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049054 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049054 Vd NA 0.8984 L/kg 1compartment NA NA Rat Human +DTXSID2049054 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2049054 TK.Half.Life NA 2.291 hours 1compartment NA NA Rat Human +DTXSID2049054 Css NA 0.002981 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049054 Css NA 0.01812 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049054 Css NA 0.001918 mg/L PBTK NA 50% Rat Human +DTXSID2049054 Css NA 0.01083 mg/L PBTK NA 95% Rat Human +DTXSID2049056 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049056 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049056 Vd NA 2.253 L/kg 1compartment NA NA Human Human DTXSID2049056 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049056 TK.Half.Life NA 2.957 hours 1compartment NA NA Human Human -DTXSID2049056 Css NA 0.1507 mg/L 3compartmentss NA 50% Human Human -DTXSID2049056 Css NA 1.401 mg/L 3compartmentss NA 95% Human Human -DTXSID2049056 Css NA 0.1417 mg/L PBTK NA 50% Human Human -DTXSID2049056 Css NA 0.9631 mg/L PBTK NA 95% Human Human -DTXSID2049056 Clint NA 3.943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049056 Fup NA 0.5883 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049056 Vd NA 1.58 L/kg 1compartment NA NA Rat Human +DTXSID2049056 TK.Half.Life NA 7.911 hours 1compartment NA NA Human Human +DTXSID2049056 Css NA 0.3214 mg/L 3compartmentss NA 50% Human Human +DTXSID2049056 Css NA 1.794 mg/L 3compartmentss NA 95% Human Human +DTXSID2049056 Css NA 0.2484 mg/L PBTK NA 50% Human Human +DTXSID2049056 Css NA 1.281 mg/L PBTK NA 95% Human Human +DTXSID2049056 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049056 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049056 Vd NA 1.757 L/kg 1compartment NA NA Rat Human DTXSID2049056 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049056 TK.Half.Life NA 1.639 hours 1compartment NA NA Rat Human -DTXSID2049056 Css NA 0.0705 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049056 Css NA 0.574 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049056 Css NA 0.06458 mg/L PBTK NA 50% Rat Human -DTXSID2049056 Css NA 0.3632 mg/L PBTK NA 95% Rat Human -DTXSID2049058 Clint NA 7.046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049058 Fup NA 0.4228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049058 Vd NA 0.4472 L/kg 1compartment NA NA Human Human +DTXSID2049056 TK.Half.Life NA 2.426 hours 1compartment NA NA Rat Human +DTXSID2049056 Css NA 0.03789 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049056 Css NA 0.1563 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049056 Css NA 0.02933 mg/L PBTK NA 50% Rat Human +DTXSID2049056 Css NA 0.1094 mg/L PBTK NA 95% Rat Human +DTXSID2049058 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049058 Fup 0.606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049058 Vd NA 0.5384 L/kg 1compartment NA NA Human Human DTXSID2049058 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049058 TK.Half.Life NA 0.8292 hours 1compartment NA NA Human Human -DTXSID2049058 Css NA 0.1493 mg/L 3compartmentss NA 50% Human Human -DTXSID2049058 Css NA 1.042 mg/L 3compartmentss NA 95% Human Human -DTXSID2049058 Css NA 0.1064 mg/L PBTK NA 50% Human Human -DTXSID2049058 Css NA 0.6668 mg/L PBTK NA 95% Human Human -DTXSID2049058 Clint NA 7.046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049058 Fup NA 0.4228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049058 Vd NA 0.446 L/kg 1compartment NA NA Rat Human +DTXSID2049058 TK.Half.Life NA 5.762 hours 1compartment NA NA Human Human +DTXSID2049058 Css NA 1.256 mg/L 3compartmentss NA 50% Human Human +DTXSID2049058 Css NA 7.983 mg/L 3compartmentss NA 95% Human Human +DTXSID2049058 Css NA 0.9563 mg/L PBTK NA 50% Human Human +DTXSID2049058 Css NA 4.969 mg/L PBTK NA 95% Human Human +DTXSID2049058 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049058 Fup 0.606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049058 Vd NA 0.5387 L/kg 1compartment NA NA Rat Human DTXSID2049058 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049058 TK.Half.Life NA 0.4557 hours 1compartment NA NA Rat Human -DTXSID2049058 Css NA 0.07606 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049058 Css NA 0.3932 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049058 Css NA 0.05165 mg/L PBTK NA 50% Rat Human -DTXSID2049058 Css NA 0.2351 mg/L PBTK NA 95% Rat Human -DTXSID2049135 Clint NA 3.025 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049135 Fup NA 0.0832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049135 Vd NA 1.639 L/kg 1compartment NA NA Human Human -DTXSID2049135 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2049135 TK.Half.Life NA 24.3 hours 1compartment NA NA Human Human -DTXSID2049135 Css NA 2.12 mg/L 3compartmentss NA 50% Human Human -DTXSID2049135 Css NA 12.85 mg/L 3compartmentss NA 95% Human Human -DTXSID2049135 Css NA 1.467 mg/L PBTK NA 50% Human Human -DTXSID2049135 Css NA 7.905 mg/L PBTK NA 95% Human Human -DTXSID2049135 Clint NA 3.025 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049135 Fup NA 0.0832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049135 Vd NA 1.379 L/kg 1compartment NA NA Rat Human -DTXSID2049135 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID2049135 TK.Half.Life NA 10.37 hours 1compartment NA NA Rat Human -DTXSID2049135 Css NA 1.056 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049135 Css NA 4.684 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049135 Css NA 0.6878 mg/L PBTK NA 50% Rat Human -DTXSID2049135 Css NA 2.697 mg/L PBTK NA 95% Rat Human -DTXSID2049210 Clint NA 3.975 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049210 Fup NA 0.0702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049210 Vd NA 2.055 L/kg 1compartment NA NA Human Human -DTXSID2049210 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID2049210 TK.Half.Life NA 38.11 hours 1compartment NA NA Human Human -DTXSID2049210 Css NA 2.662 mg/L 3compartmentss NA 50% Human Human -DTXSID2049210 Css NA 13.71 mg/L 3compartmentss NA 95% Human Human -DTXSID2049210 Css NA 1.777 mg/L PBTK NA 50% Human Human -DTXSID2049210 Css NA 8.727 mg/L PBTK NA 95% Human Human -DTXSID2049210 Clint NA 3.975 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049210 Fup NA 0.0702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049210 Vd NA 1.546 L/kg 1compartment NA NA Rat Human -DTXSID2049210 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID2049210 TK.Half.Life NA 11.33 hours 1compartment NA NA Rat Human -DTXSID2049210 Css NA 1.364 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049210 Css NA 5.108 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049210 Css NA 0.8616 mg/L PBTK NA 50% Rat Human -DTXSID2049210 Css NA 3.043 mg/L PBTK NA 95% Rat Human -DTXSID2049216 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049216 Fup NA 0.0493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049216 Vd NA 13390 L/kg 1compartment NA NA Human Human -DTXSID2049216 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID2049216 TK.Half.Life NA 693100000 hours 1compartment NA NA Human Human -DTXSID2049216 Css NA 1.435 mg/L 3compartmentss NA 50% Human Human -DTXSID2049216 Css NA 3.893 mg/L 3compartmentss NA 95% Human Human -DTXSID2049216 Css NA 3650 mg/L PBTK NA 50% Human Human -DTXSID2049216 Css NA 7837 mg/L PBTK NA 95% Human Human -DTXSID2049216 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049216 Fup NA 0.0493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049216 Vd NA 12620 L/kg 1compartment NA NA Rat Human -DTXSID2049216 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID2049216 TK.Half.Life NA 49510000 hours 1compartment NA NA Rat Human -DTXSID2049216 Css NA 0.3441 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049216 Css NA 0.6418 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049216 Css NA 970.2 mg/L PBTK NA 50% Rat Human -DTXSID2049216 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID2049260 Clint NA 10.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049260 Fup NA 0.0391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049260 Vd NA 2.771 L/kg 1compartment NA NA Human Human -DTXSID2049260 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID2049260 TK.Half.Life NA 57.52 hours 1compartment NA NA Human Human -DTXSID2049260 Css NA 2.836 mg/L 3compartmentss NA 50% Human Human -DTXSID2049260 Css NA 18.12 mg/L 3compartmentss NA 95% Human Human -DTXSID2049260 Css NA 1.927 mg/L PBTK NA 50% Human Human -DTXSID2049260 Css NA 11.7 mg/L PBTK NA 95% Human Human -DTXSID2049260 Clint NA 10.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049260 Fup NA 0.0391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049260 Vd NA 2.075 L/kg 1compartment NA NA Rat Human -DTXSID2049260 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID2049260 TK.Half.Life NA 11.39 hours 1compartment NA NA Rat Human -DTXSID2049260 Css NA 1.571 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049260 Css NA 7.546 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049260 Css NA 1.013 mg/L PBTK NA 50% Rat Human -DTXSID2049260 Css NA 4.687 mg/L PBTK NA 95% Rat Human -DTXSID2049262 Clint NA 4.465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049262 Fup NA 0.7935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049262 Vd NA 1.411 L/kg 1compartment NA NA Human Human +DTXSID2049058 TK.Half.Life NA 1.961 hours 1compartment NA NA Rat Human +DTXSID2049058 Css NA 0.0765 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049058 Css NA 0.4653 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049058 Css NA 0.05762 mg/L PBTK NA 50% Rat Human +DTXSID2049058 Css NA 0.279 mg/L PBTK NA 95% Rat Human +DTXSID2049135 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049135 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049135 Vd NA 1.969 L/kg 1compartment NA NA Human Human +DTXSID2049135 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2049135 TK.Half.Life NA 4.731 hours 1compartment NA NA Human Human +DTXSID2049135 Css NA 0.2268 mg/L 3compartmentss NA 50% Human Human +DTXSID2049135 Css NA 1.73 mg/L 3compartmentss NA 95% Human Human +DTXSID2049135 Css NA 0.1651 mg/L PBTK NA 50% Human Human +DTXSID2049135 Css NA 1.17 mg/L PBTK NA 95% Human Human +DTXSID2049135 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049135 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049135 Vd NA 1.67 L/kg 1compartment NA NA Rat Human +DTXSID2049135 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2049135 TK.Half.Life NA 2.037 hours 1compartment NA NA Rat Human +DTXSID2049135 Css NA 0.02901 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049135 Css NA 0.1791 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049135 Css NA 0.02094 mg/L PBTK NA 50% Rat Human +DTXSID2049135 Css NA 0.1158 mg/L PBTK NA 95% Rat Human +DTXSID2049210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049210 Fup 0.0369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049210 Vd NA 1.619 L/kg 1compartment NA NA Human Human +DTXSID2049210 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2049210 TK.Half.Life NA 9.759 hours 1compartment NA NA Human Human +DTXSID2049210 Css NA 0.8609 mg/L 3compartmentss NA 50% Human Human +DTXSID2049210 Css NA 7.177 mg/L 3compartmentss NA 95% Human Human +DTXSID2049210 Css NA 0.5484 mg/L PBTK NA 50% Human Human +DTXSID2049210 Css NA 4.381 mg/L PBTK NA 95% Human Human +DTXSID2049210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049210 Fup 0.0369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049210 Vd NA 1.21 L/kg 1compartment NA NA Rat Human +DTXSID2049210 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2049210 TK.Half.Life NA 3.629 hours 1compartment NA NA Rat Human +DTXSID2049210 Css NA 0.1134 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049210 Css NA 0.7041 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049210 Css NA 0.07052 mg/L PBTK NA 50% Rat Human +DTXSID2049210 Css NA 0.4215 mg/L PBTK NA 95% Rat Human +DTXSID2049260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049260 Fup 0.00672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049260 Vd NA 1.848 L/kg 1compartment NA NA Human Human +DTXSID2049260 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2049260 TK.Half.Life NA 35.78 hours 1compartment NA NA Human Human +DTXSID2049260 Css NA 3.093 mg/L 3compartmentss NA 50% Human Human +DTXSID2049260 Css NA 27.35 mg/L 3compartmentss NA 95% Human Human +DTXSID2049260 Css NA 1.936 mg/L PBTK NA 50% Human Human +DTXSID2049260 Css NA 16.56 mg/L PBTK NA 95% Human Human +DTXSID2049260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049260 Fup 0.00672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049260 Vd NA 1.365 L/kg 1compartment NA NA Rat Human +DTXSID2049260 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID2049260 TK.Half.Life NA 12.2 hours 1compartment NA NA Rat Human +DTXSID2049260 Css NA 0.4016 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049260 Css NA 2.856 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049260 Css NA 0.2462 mg/L PBTK NA 50% Rat Human +DTXSID2049260 Css NA 1.693 mg/L PBTK NA 95% Rat Human +DTXSID2049262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049262 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049262 Vd NA 0.9772 L/kg 1compartment NA NA Human Human DTXSID2049262 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049262 TK.Half.Life NA 2.097 hours 1compartment NA NA Human Human -DTXSID2049262 Css NA 0.1177 mg/L 3compartmentss NA 50% Human Human -DTXSID2049262 Css NA 0.9885 mg/L 3compartmentss NA 95% Human Human -DTXSID2049262 Css NA 0.1059 mg/L PBTK NA 50% Human Human -DTXSID2049262 Css NA 0.7033 mg/L PBTK NA 95% Human Human -DTXSID2049262 Clint NA 4.465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049262 Fup NA 0.7935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049262 Vd NA 1.277 L/kg 1compartment NA NA Rat Human +DTXSID2049262 TK.Half.Life NA 1.037 hours 1compartment NA NA Human Human +DTXSID2049262 Css NA 0.04501 mg/L 3compartmentss NA 50% Human Human +DTXSID2049262 Css NA 0.3625 mg/L 3compartmentss NA 95% Human Human +DTXSID2049262 Css NA 0.03504 mg/L PBTK NA 50% Human Human +DTXSID2049262 Css NA 0.256 mg/L PBTK NA 95% Human Human +DTXSID2049262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049262 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049262 Vd NA 0.8819 L/kg 1compartment NA NA Rat Human DTXSID2049262 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049262 TK.Half.Life NA 0.9659 hours 1compartment NA NA Rat Human -DTXSID2049262 Css NA 0.0546 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049262 Css NA 0.4076 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049262 Css NA 0.04876 mg/L PBTK NA 50% Rat Human -DTXSID2049262 Css NA 0.2629 mg/L PBTK NA 95% Rat Human -DTXSID2049268 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049268 Fup NA 0.0949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049268 Vd NA 0.4035 L/kg 1compartment NA NA Human Human -DTXSID2049268 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID2049268 TK.Half.Life NA 27.86 hours 1compartment NA NA Human Human -DTXSID2049268 Css NA 10.8 mg/L 3compartmentss NA 50% Human Human -DTXSID2049268 Css NA 49.22 mg/L 3compartmentss NA 95% Human Human -DTXSID2049268 Css NA 6.719 mg/L PBTK NA 50% Human Human -DTXSID2049268 Css NA 28.96 mg/L PBTK NA 95% Human Human -DTXSID2049268 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049268 Fup NA 0.0949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049268 Vd NA 0.3587 L/kg 1compartment NA NA Rat Human +DTXSID2049262 TK.Half.Life NA 0.4731 hours 1compartment NA NA Rat Human +DTXSID2049262 Css NA 0.005453 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049262 Css NA 0.03707 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049262 Css NA 0.00428 mg/L PBTK NA 50% Rat Human +DTXSID2049262 Css NA 0.02522 mg/L PBTK NA 95% Rat Human +DTXSID2049268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049268 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049268 Vd NA 1.358 L/kg 1compartment NA NA Human Human +DTXSID2049268 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2049268 TK.Half.Life NA 3.558 hours 1compartment NA NA Human Human +DTXSID2049268 Css NA 0.2758 mg/L 3compartmentss NA 50% Human Human +DTXSID2049268 Css NA 2.056 mg/L 3compartmentss NA 95% Human Human +DTXSID2049268 Css NA 0.1824 mg/L PBTK NA 50% Human Human +DTXSID2049268 Css NA 1.286 mg/L PBTK NA 95% Human Human +DTXSID2049268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049268 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049268 Vd NA 1.049 L/kg 1compartment NA NA Rat Human DTXSID2049268 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049268 TK.Half.Life NA 8.357 hours 1compartment NA NA Rat Human -DTXSID2049268 Css NA 3.021 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049268 Css NA 11.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049268 Css NA 1.768 mg/L PBTK NA 50% Rat Human -DTXSID2049268 Css NA 6.548 mg/L PBTK NA 95% Rat Human -DTXSID2049391 Clint NA 218.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049391 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049391 Vd NA 381.9 L/kg 1compartment NA NA Human Human -DTXSID2049391 Days.Css NA 271 Days PBTK NA NA Human Human -DTXSID2049391 TK.Half.Life NA 1122 hours 1compartment NA NA Human Human -DTXSID2049391 Css NA 0.004404 mg/L 3compartmentss NA 50% Human Human -DTXSID2049391 Css NA 0.02646 mg/L 3compartmentss NA 95% Human Human -DTXSID2049391 Css NA 0.2447 mg/L PBTK NA 50% Human Human -DTXSID2049391 Css NA 1.31 mg/L PBTK NA 95% Human Human -DTXSID2049391 Clint NA 218.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049391 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049391 Vd NA 343 L/kg 1compartment NA NA Rat Human -DTXSID2049391 Days.Css NA 184 Days PBTK NA NA Rat Human -DTXSID2049391 TK.Half.Life NA 174.7 hours 1compartment NA NA Rat Human -DTXSID2049391 Css NA 0.002224 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049391 Css NA 0.009685 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049391 Css NA 0.1316 mg/L PBTK NA 50% Rat Human -DTXSID2049391 Css NA 0.5673 mg/L PBTK NA 95% Rat Human -DTXSID2049393 Clint NA 46.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049393 Fup NA 0.0555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049393 Vd NA 2.405 L/kg 1compartment NA NA Human Human -DTXSID2049393 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049393 TK.Half.Life NA 7.605 hours 1compartment NA NA Human Human -DTXSID2049393 Css NA 0.3497 mg/L 3compartmentss NA 50% Human Human -DTXSID2049393 Css NA 2.395 mg/L 3compartmentss NA 95% Human Human -DTXSID2049393 Css NA 0.2382 mg/L PBTK NA 50% Human Human -DTXSID2049393 Css NA 1.571 mg/L PBTK NA 95% Human Human -DTXSID2049393 Clint NA 46.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049393 Fup NA 0.0555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049393 Vd NA 1.844 L/kg 1compartment NA NA Rat Human -DTXSID2049393 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049393 TK.Half.Life NA 2.291 hours 1compartment NA NA Rat Human -DTXSID2049393 Css NA 0.1941 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049393 Css NA 1.146 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049393 Css NA 0.1257 mg/L PBTK NA 50% Rat Human -DTXSID2049393 Css NA 0.7064 mg/L PBTK NA 95% Rat Human -DTXSID2049397 Clint NA 9.955 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049397 Fup NA 0.0161 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049397 Vd NA 200.8 L/kg 1compartment NA NA Human Human -DTXSID2049397 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID2049397 TK.Half.Life NA 12880 hours 1compartment NA NA Human Human -DTXSID2049397 Css NA 0.1979 mg/L 3compartmentss NA 50% Human Human -DTXSID2049397 Css NA 1.19 mg/L 3compartmentss NA 95% Human Human -DTXSID2049397 Css NA 5.298 mg/L PBTK NA 50% Human Human -DTXSID2049397 Css NA 28.72 mg/L PBTK NA 95% Human Human -DTXSID2049397 Clint NA 9.955 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049397 Fup NA 0.0161 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049397 Vd NA 177.4 L/kg 1compartment NA NA Rat Human -DTXSID2049397 Days.Css NA 2198 Days PBTK NA NA Rat Human -DTXSID2049397 TK.Half.Life NA 1951 hours 1compartment NA NA Rat Human -DTXSID2049397 Css NA 0.09998 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049397 Css NA 0.4253 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049397 Css NA 2.865 mg/L PBTK NA 50% Rat Human -DTXSID2049397 Css NA 12.46 mg/L PBTK NA 95% Rat Human -DTXSID2049399 Clint NA 0.01422 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049399 Fup NA 0.7791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049399 Vd NA 2.007 L/kg 1compartment NA NA Human Human +DTXSID2049268 TK.Half.Life NA 1.432 hours 1compartment NA NA Rat Human +DTXSID2049268 Css NA 0.03527 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049268 Css NA 0.2153 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049268 Css NA 0.02284 mg/L PBTK NA 50% Rat Human +DTXSID2049268 Css NA 0.1318 mg/L PBTK NA 95% Rat Human +DTXSID2049393 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049393 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049393 Vd NA 2.438 L/kg 1compartment NA NA Human Human +DTXSID2049393 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID2049393 TK.Half.Life NA 28.49 hours 1compartment NA NA Human Human +DTXSID2049393 Css NA 1.646 mg/L 3compartmentss NA 50% Human Human +DTXSID2049393 Css NA 12.19 mg/L 3compartmentss NA 95% Human Human +DTXSID2049393 Css NA 1.091 mg/L PBTK NA 50% Human Human +DTXSID2049393 Css NA 7.742 mg/L PBTK NA 95% Human Human +DTXSID2049393 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049393 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049393 Vd NA 1.837 L/kg 1compartment NA NA Rat Human +DTXSID2049393 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2049393 TK.Half.Life NA 7.638 hours 1compartment NA NA Rat Human +DTXSID2049393 Css NA 0.2094 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049393 Css NA 1.349 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049393 Css NA 0.1364 mg/L PBTK NA 50% Rat Human +DTXSID2049393 Css NA 0.8502 mg/L PBTK NA 95% Rat Human +DTXSID2049397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049397 Fup 0.0286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049397 Vd NA 3.125 L/kg 1compartment NA NA Human Human +DTXSID2049397 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID2049397 TK.Half.Life NA 91.52 hours 1compartment NA NA Human Human +DTXSID2049397 Css NA 1.892 mg/L 3compartmentss NA 50% Human Human +DTXSID2049397 Css NA 12.36 mg/L 3compartmentss NA 95% Human Human +DTXSID2049397 Css NA 1.311 mg/L PBTK NA 50% Human Human +DTXSID2049397 Css NA 8.465 mg/L PBTK NA 95% Human Human +DTXSID2049397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049397 Fup 0.0286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049397 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID2049397 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID2049397 TK.Half.Life NA 12.22 hours 1compartment NA NA Rat Human +DTXSID2049397 Css NA 0.0203 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049397 Css NA 0.1274 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049397 Css NA 0.01354 mg/L PBTK NA 50% Rat Human +DTXSID2049397 Css NA 0.08409 mg/L PBTK NA 95% Rat Human +DTXSID2049399 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049399 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049399 Vd NA 1.466 L/kg 1compartment NA NA Human Human DTXSID2049399 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2049399 TK.Half.Life NA 16.28 hours 1compartment NA NA Human Human -DTXSID2049399 Css NA 0.7794 mg/L 3compartmentss NA 50% Human Human -DTXSID2049399 Css NA 5.464 mg/L 3compartmentss NA 95% Human Human -DTXSID2049399 Css NA 0.809 mg/L PBTK NA 50% Human Human -DTXSID2049399 Css NA 3.885 mg/L PBTK NA 95% Human Human -DTXSID2049399 Clint NA 0.01422 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049399 Fup NA 0.7791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049399 Vd NA 2.003 L/kg 1compartment NA NA Rat Human +DTXSID2049399 TK.Half.Life NA 14.46 hours 1compartment NA NA Human Human +DTXSID2049399 Css NA 0.9577 mg/L 3compartmentss NA 50% Human Human +DTXSID2049399 Css NA 6.958 mg/L 3compartmentss NA 95% Human Human +DTXSID2049399 Css NA 0.8972 mg/L PBTK NA 50% Human Human +DTXSID2049399 Css NA 4.653 mg/L PBTK NA 95% Human Human +DTXSID2049399 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049399 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049399 Vd NA 1.462 L/kg 1compartment NA NA Rat Human DTXSID2049399 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049399 TK.Half.Life NA 5.603 hours 1compartment NA NA Rat Human -DTXSID2049399 Css NA 0.1972 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049399 Css NA 1.473 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049399 Css NA 0.2031 mg/L PBTK NA 50% Rat Human -DTXSID2049399 Css NA 0.9494 mg/L PBTK NA 95% Rat Human -DTXSID2049420 Clint NA 0.6109 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049420 Fup NA 0.3758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049420 Vd NA 0.7465 L/kg 1compartment NA NA Human Human +DTXSID2049399 TK.Half.Life NA 4.916 hours 1compartment NA NA Rat Human +DTXSID2049399 Css NA 0.05685 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049399 Css NA 0.4051 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049399 Css NA 0.05388 mg/L PBTK NA 50% Rat Human +DTXSID2049399 Css NA 0.2588 mg/L PBTK NA 95% Rat Human +DTXSID2049420 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049420 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049420 Vd NA 0.743 L/kg 1compartment NA NA Human Human DTXSID2049420 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049420 TK.Half.Life NA 6.627 hours 1compartment NA NA Human Human -DTXSID2049420 Css NA 0.9452 mg/L 3compartmentss NA 50% Human Human -DTXSID2049420 Css NA 4.322 mg/L 3compartmentss NA 95% Human Human -DTXSID2049420 Css NA 0.7139 mg/L PBTK NA 50% Human Human -DTXSID2049420 Css NA 2.789 mg/L PBTK NA 95% Human Human -DTXSID2049420 Clint NA 0.6109 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049420 Fup NA 0.3758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049420 Vd NA 0.7 L/kg 1compartment NA NA Rat Human +DTXSID2049420 TK.Half.Life NA 0.8191 hours 1compartment NA NA Human Human +DTXSID2049420 Css NA 0.04792 mg/L 3compartmentss NA 50% Human Human +DTXSID2049420 Css NA 0.3787 mg/L 3compartmentss NA 95% Human Human +DTXSID2049420 Css NA 0.036 mg/L PBTK NA 50% Human Human +DTXSID2049420 Css NA 0.256 mg/L PBTK NA 95% Human Human +DTXSID2049420 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049420 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049420 Vd NA 0.7056 L/kg 1compartment NA NA Rat Human DTXSID2049420 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049420 TK.Half.Life NA 2.78 hours 1compartment NA NA Rat Human -DTXSID2049420 Css NA 0.3508 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049420 Css NA 1.344 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049420 Css NA 0.2538 mg/L PBTK NA 50% Rat Human -DTXSID2049420 Css NA 0.8079 mg/L PBTK NA 95% Rat Human -DTXSID2049422 Clint NA 18.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049422 Fup NA 0.7395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049422 Vd NA 3.004 L/kg 1compartment NA NA Human Human +DTXSID2049420 TK.Half.Life NA 0.3988 hours 1compartment NA NA Rat Human +DTXSID2049420 Css NA 0.005782 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049420 Css NA 0.03866 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049420 Css NA 0.004388 mg/L PBTK NA 50% Rat Human +DTXSID2049420 Css NA 0.02558 mg/L PBTK NA 95% Rat Human +DTXSID2049422 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049422 Fup 0.657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049422 Vd NA 1.626 L/kg 1compartment NA NA Human Human DTXSID2049422 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049422 TK.Half.Life NA 1.987 hours 1compartment NA NA Human Human -DTXSID2049422 Css NA 0.02522 mg/L 3compartmentss NA 50% Human Human -DTXSID2049422 Css NA 0.2956 mg/L 3compartmentss NA 95% Human Human -DTXSID2049422 Css NA 0.02868 mg/L PBTK NA 50% Human Human -DTXSID2049422 Css NA 0.2377 mg/L PBTK NA 95% Human Human -DTXSID2049422 Clint NA 18.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049422 Fup NA 0.7395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049422 Vd NA 3.054 L/kg 1compartment NA NA Rat Human +DTXSID2049422 TK.Half.Life NA 2.137 hours 1compartment NA NA Human Human +DTXSID2049422 Css NA 0.07661 mg/L 3compartmentss NA 50% Human Human +DTXSID2049422 Css NA 0.791 mg/L 3compartmentss NA 95% Human Human +DTXSID2049422 Css NA 0.07182 mg/L PBTK NA 50% Human Human +DTXSID2049422 Css NA 0.5696 mg/L PBTK NA 95% Human Human +DTXSID2049422 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049422 Fup 0.657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049422 Vd NA 1.651 L/kg 1compartment NA NA Rat Human DTXSID2049422 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049422 TK.Half.Life NA 1.047 hours 1compartment NA NA Rat Human -DTXSID2049422 Css NA 0.01222 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049422 Css NA 0.1251 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049422 Css NA 0.01436 mg/L PBTK NA 50% Rat Human -DTXSID2049422 Css NA 0.09836 mg/L PBTK NA 95% Rat Human -DTXSID2049424 Clint NA 0.588 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049424 Fup NA 0.6215 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049424 Vd NA 2.622 L/kg 1compartment NA NA Human Human -DTXSID2049424 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2049424 TK.Half.Life NA 13.92 hours 1compartment NA NA Human Human -DTXSID2049424 Css NA 0.4154 mg/L 3compartmentss NA 50% Human Human -DTXSID2049424 Css NA 3.592 mg/L 3compartmentss NA 95% Human Human -DTXSID2049424 Css NA 0.4784 mg/L PBTK NA 50% Human Human -DTXSID2049424 Css NA 2.622 mg/L PBTK NA 95% Human Human -DTXSID2049424 Clint NA 0.588 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049424 Fup NA 0.6215 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049424 Vd NA 2.623 L/kg 1compartment NA NA Rat Human +DTXSID2049422 TK.Half.Life NA 1.188 hours 1compartment NA NA Rat Human +DTXSID2049422 Css NA 0.003376 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049422 Css NA 0.0397 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049422 Css NA 0.003253 mg/L PBTK NA 50% Rat Human +DTXSID2049422 Css NA 0.0284 mg/L PBTK NA 95% Rat Human +DTXSID2049424 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049424 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049424 Vd NA 2.185 L/kg 1compartment NA NA Human Human +DTXSID2049424 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2049424 TK.Half.Life NA 1.822 hours 1compartment NA NA Human Human +DTXSID2049424 Css NA 0.02958 mg/L 3compartmentss NA 50% Human Human +DTXSID2049424 Css NA 0.2963 mg/L 3compartmentss NA 95% Human Human +DTXSID2049424 Css NA 0.03057 mg/L PBTK NA 50% Human Human +DTXSID2049424 Css NA 0.2363 mg/L PBTK NA 95% Human Human +DTXSID2049424 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049424 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049424 Vd NA 2.179 L/kg 1compartment NA NA Rat Human DTXSID2049424 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049424 TK.Half.Life NA 6.313 hours 1compartment NA NA Rat Human -DTXSID2049424 Css NA 0.1443 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049424 Css NA 1.221 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049424 Css NA 0.1651 mg/L PBTK NA 50% Rat Human -DTXSID2049424 Css NA 0.8104 mg/L PBTK NA 95% Rat Human -DTXSID2049426 Clint NA 0.6227 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049426 Fup NA 0.3177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049426 Vd NA 1.633 L/kg 1compartment NA NA Human Human -DTXSID2049426 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID2049426 TK.Half.Life NA 21.57 hours 1compartment NA NA Human Human -DTXSID2049426 Css NA 1.396 mg/L 3compartmentss NA 50% Human Human -DTXSID2049426 Css NA 5.573 mg/L 3compartmentss NA 95% Human Human -DTXSID2049426 Css NA 1.083 mg/L PBTK NA 50% Human Human -DTXSID2049426 Css NA 3.7 mg/L PBTK NA 95% Human Human -DTXSID2049426 Clint NA 0.6227 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049426 Fup NA 0.3177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049426 Vd NA 1.313 L/kg 1compartment NA NA Rat Human +DTXSID2049424 TK.Half.Life NA 0.9571 hours 1compartment NA NA Rat Human +DTXSID2049424 Css NA 0.003464 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049424 Css NA 0.02805 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049424 Css NA 0.003726 mg/L PBTK NA 50% Rat Human +DTXSID2049424 Css NA 0.02239 mg/L PBTK NA 95% Rat Human +DTXSID2049426 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049426 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049426 Vd NA 1.175 L/kg 1compartment NA NA Human Human +DTXSID2049426 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2049426 TK.Half.Life NA 2.272 hours 1compartment NA NA Human Human +DTXSID2049426 Css NA 0.1518 mg/L 3compartmentss NA 50% Human Human +DTXSID2049426 Css NA 1.099 mg/L 3compartmentss NA 95% Human Human +DTXSID2049426 Css NA 0.1042 mg/L PBTK NA 50% Human Human +DTXSID2049426 Css NA 0.709 mg/L PBTK NA 95% Human Human +DTXSID2049426 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049426 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049426 Vd NA 0.9372 L/kg 1compartment NA NA Rat Human DTXSID2049426 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049426 TK.Half.Life NA 6.448 hours 1compartment NA NA Rat Human -DTXSID2049426 Css NA 0.5252 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049426 Css NA 1.685 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049426 Css NA 0.39 mg/L PBTK NA 50% Rat Human -DTXSID2049426 Css NA 1.05 mg/L PBTK NA 95% Rat Human -DTXSID2049428 Clint NA 0.1939 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049428 Fup NA 0.6123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2049428 Vd NA 1.019 L/kg 1compartment NA NA Human Human +DTXSID2049426 TK.Half.Life NA 0.9563 hours 1compartment NA NA Rat Human +DTXSID2049426 Css NA 0.01966 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049426 Css NA 0.1093 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049426 Css NA 0.0133 mg/L PBTK NA 50% Rat Human +DTXSID2049426 Css NA 0.06954 mg/L PBTK NA 95% Rat Human +DTXSID2049428 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049428 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2049428 Vd NA 0.7669 L/kg 1compartment NA NA Human Human DTXSID2049428 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2049428 TK.Half.Life NA 8.514 hours 1compartment NA NA Human Human -DTXSID2049428 Css NA 0.8656 mg/L 3compartmentss NA 50% Human Human -DTXSID2049428 Css NA 5.902 mg/L 3compartmentss NA 95% Human Human -DTXSID2049428 Css NA 0.7325 mg/L PBTK NA 50% Human Human -DTXSID2049428 Css NA 3.796 mg/L PBTK NA 95% Human Human -DTXSID2049428 Clint NA 0.1939 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049428 Fup NA 0.6123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2049428 Vd NA 0.9513 L/kg 1compartment NA NA Rat Human +DTXSID2049428 TK.Half.Life NA 0.9892 hours 1compartment NA NA Human Human +DTXSID2049428 Css NA 0.06579 mg/L 3compartmentss NA 50% Human Human +DTXSID2049428 Css NA 0.5263 mg/L 3compartmentss NA 95% Human Human +DTXSID2049428 Css NA 0.04803 mg/L PBTK NA 50% Human Human +DTXSID2049428 Css NA 0.3519 mg/L PBTK NA 95% Human Human +DTXSID2049428 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049428 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2049428 Vd NA 0.6946 L/kg 1compartment NA NA Rat Human DTXSID2049428 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2049428 TK.Half.Life NA 2.993 hours 1compartment NA NA Rat Human -DTXSID2049428 Css NA 0.2682 mg/L 3compartmentss NA 50% Rat Human -DTXSID2049428 Css NA 1.764 mg/L 3compartmentss NA 95% Rat Human -DTXSID2049428 Css NA 0.2185 mg/L PBTK NA 50% Rat Human -DTXSID2049428 Css NA 1.054 mg/L PBTK NA 95% Rat Human -DTXSID2051631 Clint NA 59.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2051631 Fup NA 0.6373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2051631 Vd NA 0.6637 L/kg 1compartment NA NA Human Human +DTXSID2049428 TK.Half.Life NA 0.4706 hours 1compartment NA NA Rat Human +DTXSID2049428 Css NA 0.008246 mg/L 3compartmentss NA 50% Rat Human +DTXSID2049428 Css NA 0.04743 mg/L 3compartmentss NA 95% Rat Human +DTXSID2049428 Css NA 0.005964 mg/L PBTK NA 50% Rat Human +DTXSID2049428 Css NA 0.03114 mg/L PBTK NA 95% Rat Human +DTXSID2051631 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2051631 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2051631 Vd NA 0.529 L/kg 1compartment NA NA Human Human DTXSID2051631 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2051631 TK.Half.Life NA 0.4902 hours 1compartment NA NA Human Human -DTXSID2051631 Css NA 0.01299 mg/L 3compartmentss NA 50% Human Human -DTXSID2051631 Css NA 0.1454 mg/L 3compartmentss NA 95% Human Human -DTXSID2051631 Css NA 0.01024 mg/L PBTK NA 50% Human Human -DTXSID2051631 Css NA 0.09532 mg/L PBTK NA 95% Human Human -DTXSID2051631 Clint NA 59.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2051631 Fup NA 0.6373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2051631 Vd NA 0.6811 L/kg 1compartment NA NA Rat Human +DTXSID2051631 TK.Half.Life NA 8.957 hours 1compartment NA NA Human Human +DTXSID2051631 Css NA 1.858 mg/L 3compartmentss NA 50% Human Human +DTXSID2051631 Css NA 8.01 mg/L 3compartmentss NA 95% Human Human +DTXSID2051631 Css NA 1.347 mg/L PBTK NA 50% Human Human +DTXSID2051631 Css NA 5.09 mg/L PBTK NA 95% Human Human +DTXSID2051631 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2051631 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2051631 Vd NA 0.5344 L/kg 1compartment NA NA Rat Human DTXSID2051631 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2051631 TK.Half.Life NA 0.2314 hours 1compartment NA NA Rat Human -DTXSID2051631 Css NA 0.006882 mg/L 3compartmentss NA 50% Rat Human -DTXSID2051631 Css NA 0.06642 mg/L 3compartmentss NA 95% Rat Human -DTXSID2051631 Css NA 0.005263 mg/L PBTK NA 50% Rat Human -DTXSID2051631 Css NA 0.04278 mg/L PBTK NA 95% Rat Human -DTXSID2051687 Clint NA 13.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2051687 Fup NA 0.0474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2051687 Vd NA 1.906 L/kg 1compartment NA NA Human Human -DTXSID2051687 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID2051687 TK.Half.Life NA 15.75 hours 1compartment NA NA Human Human -DTXSID2051687 Css NA 1.195 mg/L 3compartmentss NA 50% Human Human -DTXSID2051687 Css NA 8.154 mg/L 3compartmentss NA 95% Human Human -DTXSID2051687 Css NA 0.7788 mg/L PBTK NA 50% Human Human -DTXSID2051687 Css NA 5.117 mg/L PBTK NA 95% Human Human -DTXSID2051687 Clint NA 13.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2051687 Fup NA 0.0474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2051687 Vd NA 1.427 L/kg 1compartment NA NA Rat Human -DTXSID2051687 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2051687 TK.Half.Life NA 5.271 hours 1compartment NA NA Rat Human -DTXSID2051687 Css NA 0.6579 mg/L 3compartmentss NA 50% Rat Human -DTXSID2051687 Css NA 3.621 mg/L 3compartmentss NA 95% Rat Human -DTXSID2051687 Css NA 0.4048 mg/L PBTK NA 50% Rat Human -DTXSID2051687 Css NA 2.082 mg/L PBTK NA 95% Rat Human +DTXSID2051631 TK.Half.Life NA 3.079 hours 1compartment NA NA Rat Human +DTXSID2051631 Css NA 0.1192 mg/L 3compartmentss NA 50% Rat Human +DTXSID2051631 Css NA 0.4371 mg/L 3compartmentss NA 95% Rat Human +DTXSID2051631 Css NA 0.08547 mg/L PBTK NA 50% Rat Human +DTXSID2051631 Css NA 0.2667 mg/L PBTK NA 95% Rat Human +DTXSID2051687 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2051687 Fup 0.00948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2051687 Vd NA 1.411 L/kg 1compartment NA NA Human Human +DTXSID2051687 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2051687 TK.Half.Life NA 21.89 hours 1compartment NA NA Human Human +DTXSID2051687 Css NA 2.528 mg/L 3compartmentss NA 50% Human Human +DTXSID2051687 Css NA 23.06 mg/L 3compartmentss NA 95% Human Human +DTXSID2051687 Css NA 1.55 mg/L PBTK NA 50% Human Human +DTXSID2051687 Css NA 14.05 mg/L PBTK NA 95% Human Human +DTXSID2051687 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2051687 Fup 0.00948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2051687 Vd NA 1.04 L/kg 1compartment NA NA Rat Human +DTXSID2051687 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2051687 TK.Half.Life NA 8.657 hours 1compartment NA NA Rat Human +DTXSID2051687 Css NA 0.3312 mg/L 3compartmentss NA 50% Rat Human +DTXSID2051687 Css NA 2.502 mg/L 3compartmentss NA 95% Rat Human +DTXSID2051687 Css NA 0.1988 mg/L PBTK NA 50% Rat Human +DTXSID2051687 Css NA 1.437 mg/L PBTK NA 95% Rat Human +DTXSID2051710 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2051710 Fup 0.0108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2051710 Vd NA 24 L/kg 1compartment NA NA Human Human +DTXSID2051710 Days.Css NA 168 Days PBTK NA NA Human Human +DTXSID2051710 TK.Half.Life NA 713.3 hours 1compartment NA NA Human Human +DTXSID2051710 Css NA 0.5145 mg/L 3compartmentss NA 50% Human Human +DTXSID2051710 Css NA 3.594 mg/L 3compartmentss NA 95% Human Human +DTXSID2051710 Css NA 1.31 mg/L PBTK NA 50% Human Human +DTXSID2051710 Css NA 8.31 mg/L PBTK NA 95% Human Human +DTXSID2051710 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2051710 Fup 0.0108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2051710 Vd NA 19.64 L/kg 1compartment NA NA Rat Human +DTXSID2051710 Days.Css NA 102 Days PBTK NA NA Rat Human +DTXSID2051710 TK.Half.Life NA 102.6 hours 1compartment NA NA Rat Human +DTXSID2051710 Css NA 0.005224 mg/L 3compartmentss NA 50% Rat Human +DTXSID2051710 Css NA 0.03058 mg/L 3compartmentss NA 95% Rat Human +DTXSID2051710 Css NA 0.01387 mg/L PBTK NA 50% Rat Human +DTXSID2051710 Css NA 0.07916 mg/L PBTK NA 95% Rat Human DTXSID2051716 Clint NA 0.09729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2051716 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2051716 Vd NA 0.8302 L/kg 1compartment NA NA Human Human DTXSID2051716 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2051716 TK.Half.Life NA 4.646 hours 1compartment NA NA Human Human -DTXSID2051716 Css NA 0.6904 mg/L 3compartmentss NA 50% Human Human -DTXSID2051716 Css NA 4.747 mg/L 3compartmentss NA 95% Human Human -DTXSID2051716 Css NA 0.5892 mg/L PBTK NA 50% Human Human -DTXSID2051716 Css NA 3.088 mg/L PBTK NA 95% Human Human +DTXSID2051716 Css NA 0.5882 mg/L 3compartmentss NA 50% Human Human +DTXSID2051716 Css NA 3.839 mg/L 3compartmentss NA 95% Human Human +DTXSID2051716 Css NA 0.5022 mg/L PBTK NA 50% Human Human +DTXSID2051716 Css NA 2.475 mg/L PBTK NA 95% Human Human DTXSID2051716 Clint NA 0.09729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2051716 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2051716 Vd NA 0.8592 L/kg 1compartment NA NA Rat Human DTXSID2051716 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2051716 TK.Half.Life NA 1.759 hours 1compartment NA NA Rat Human -DTXSID2051716 Css NA 0.1908 mg/L 3compartmentss NA 50% Rat Human -DTXSID2051716 Css NA 1.188 mg/L 3compartmentss NA 95% Rat Human -DTXSID2051716 Css NA 0.1597 mg/L PBTK NA 50% Rat Human -DTXSID2051716 Css NA 0.7211 mg/L PBTK NA 95% Rat Human -DTXSID2052281 Clint NA 0.1448 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052281 Fup NA 0.752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052281 Vd NA 0.7412 L/kg 1compartment NA NA Human Human +DTXSID2051716 Css NA 0.01167 mg/L 3compartmentss NA 50% Rat Human +DTXSID2051716 Css NA 0.09025 mg/L 3compartmentss NA 95% Rat Human +DTXSID2051716 Css NA 0.009632 mg/L PBTK NA 50% Rat Human +DTXSID2051716 Css NA 0.06061 mg/L PBTK NA 95% Rat Human +DTXSID2051764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2051764 Fup 0.422 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2051764 Vd NA 1.334 L/kg 1compartment NA NA Human Human +DTXSID2051764 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2051764 TK.Half.Life NA 1.466 hours 1compartment NA NA Human Human +DTXSID2051764 Css NA 0.04852 mg/L 3compartmentss NA 50% Human Human +DTXSID2051764 Css NA 0.372 mg/L 3compartmentss NA 95% Human Human +DTXSID2051764 Css NA 0.03862 mg/L PBTK NA 50% Human Human +DTXSID2051764 Css NA 0.2633 mg/L PBTK NA 95% Human Human +DTXSID2051764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2051764 Fup 0.422 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2051764 Vd NA 1.13 L/kg 1compartment NA NA Rat Human +DTXSID2051764 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2051764 TK.Half.Life NA 0.6118 hours 1compartment NA NA Rat Human +DTXSID2051764 Css NA 0.005976 mg/L 3compartmentss NA 50% Rat Human +DTXSID2051764 Css NA 0.03698 mg/L 3compartmentss NA 95% Rat Human +DTXSID2051764 Css NA 0.004835 mg/L PBTK NA 50% Rat Human +DTXSID2051764 Css NA 0.02589 mg/L PBTK NA 95% Rat Human +DTXSID2051895 Clint NA 1.534 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2051895 Fup NA 0.2906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID2051895 Vd NA 1.517 L/kg 1compartment NA NA Human Human +DTXSID2051895 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2051895 TK.Half.Life NA 12.24 hours 1compartment NA NA Human Human +DTXSID2051895 Css NA 0.7261 mg/L 3compartmentss NA 50% Human Human +DTXSID2051895 Css NA 3.399 mg/L 3compartmentss NA 95% Human Human +DTXSID2051895 Css NA 0.5496 mg/L PBTK NA 50% Human Human +DTXSID2051895 Css NA 2.286 mg/L PBTK NA 95% Human Human +DTXSID2051895 Clint NA 1.534 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2051895 Fup NA 0.2906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID2051895 Vd NA 1.223 L/kg 1compartment NA NA Rat Human +DTXSID2051895 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2051895 TK.Half.Life NA 4.37 hours 1compartment NA NA Rat Human +DTXSID2051895 Css NA 0.02065 mg/L 3compartmentss NA 50% Rat Human +DTXSID2051895 Css NA 0.1257 mg/L 3compartmentss NA 95% Rat Human +DTXSID2051895 Css NA 0.01531 mg/L PBTK NA 50% Rat Human +DTXSID2051895 Css NA 0.08494 mg/L PBTK NA 95% Rat Human +DTXSID2052108 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052108 Fup 0.699 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052108 Vd NA 0.917 L/kg 1compartment NA NA Human Human +DTXSID2052108 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2052108 TK.Half.Life NA 0.7538 hours 1compartment NA NA Human Human +DTXSID2052108 Css NA 0.02212 mg/L 3compartmentss NA 50% Human Human +DTXSID2052108 Css NA 0.2794 mg/L 3compartmentss NA 95% Human Human +DTXSID2052108 Css NA 0.01846 mg/L PBTK NA 50% Human Human +DTXSID2052108 Css NA 0.196 mg/L PBTK NA 95% Human Human +DTXSID2052108 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052108 Fup 0.699 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052108 Vd NA 0.8927 L/kg 1compartment NA NA Rat Human +DTXSID2052108 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2052108 TK.Half.Life NA 0.3593 hours 1compartment NA NA Rat Human +DTXSID2052108 Css NA 0.0008066 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052108 Css NA 0.01062 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052108 Css NA 0.0006633 mg/L PBTK NA 50% Rat Human +DTXSID2052108 Css NA 0.007253 mg/L PBTK NA 95% Rat Human +DTXSID2052281 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052281 Fup 0.77 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052281 Vd NA 0.7514 L/kg 1compartment NA NA Human Human DTXSID2052281 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2052281 TK.Half.Life NA 5.177 hours 1compartment NA NA Human Human -DTXSID2052281 Css NA 0.8175 mg/L 3compartmentss NA 50% Human Human -DTXSID2052281 Css NA 4.943 mg/L 3compartmentss NA 95% Human Human -DTXSID2052281 Css NA 0.6698 mg/L PBTK NA 50% Human Human -DTXSID2052281 Css NA 3.202 mg/L PBTK NA 95% Human Human -DTXSID2052281 Clint NA 0.1448 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052281 Fup NA 0.752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052281 Vd NA 0.7575 L/kg 1compartment NA NA Rat Human +DTXSID2052281 TK.Half.Life NA 6.336 hours 1compartment NA NA Human Human +DTXSID2052281 Css NA 0.9884 mg/L 3compartmentss NA 50% Human Human +DTXSID2052281 Css NA 6.157 mg/L 3compartmentss NA 95% Human Human +DTXSID2052281 Css NA 0.8099 mg/L PBTK NA 50% Human Human +DTXSID2052281 Css NA 3.955 mg/L PBTK NA 95% Human Human +DTXSID2052281 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052281 Fup 0.77 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052281 Vd NA 0.768 L/kg 1compartment NA NA Rat Human DTXSID2052281 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2052281 TK.Half.Life NA 1.994 hours 1compartment NA NA Rat Human -DTXSID2052281 Css NA 0.2364 mg/L 3compartmentss NA 50% Rat Human -DTXSID2052281 Css NA 1.525 mg/L 3compartmentss NA 95% Rat Human -DTXSID2052281 Css NA 0.1875 mg/L PBTK NA 50% Rat Human -DTXSID2052281 Css NA 0.9052 mg/L PBTK NA 95% Rat Human -DTXSID2052283 Clint NA 0.02457 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052283 Fup NA 0.8229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052283 Vd NA 0.8994 L/kg 1compartment NA NA Human Human +DTXSID2052281 TK.Half.Life NA 2.2 hours 1compartment NA NA Rat Human +DTXSID2052281 Css NA 0.05805 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052281 Css NA 0.365 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052281 Css NA 0.04807 mg/L PBTK NA 50% Rat Human +DTXSID2052281 Css NA 0.2243 mg/L PBTK NA 95% Rat Human +DTXSID2052283 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052283 Fup 0.525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052283 Vd NA 0.7674 L/kg 1compartment NA NA Human Human DTXSID2052283 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2052283 TK.Half.Life NA 6.87 hours 1compartment NA NA Human Human -DTXSID2052283 Css NA 0.891 mg/L 3compartmentss NA 50% Human Human -DTXSID2052283 Css NA 5.433 mg/L 3compartmentss NA 95% Human Human -DTXSID2052283 Css NA 0.7673 mg/L PBTK NA 50% Human Human -DTXSID2052283 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID2052283 Clint NA 0.02457 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052283 Fup NA 0.8229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052283 Vd NA 0.8986 L/kg 1compartment NA NA Rat Human +DTXSID2052283 TK.Half.Life NA 0.7416 hours 1compartment NA NA Human Human +DTXSID2052283 Css NA 0.02927 mg/L 3compartmentss NA 50% Human Human +DTXSID2052283 Css NA 0.3021 mg/L 3compartmentss NA 95% Human Human +DTXSID2052283 Css NA 0.02332 mg/L PBTK NA 50% Human Human +DTXSID2052283 Css NA 0.2092 mg/L PBTK NA 95% Human Human +DTXSID2052283 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052283 Fup 0.525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052283 Vd NA 0.7467 L/kg 1compartment NA NA Rat Human DTXSID2052283 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2052283 TK.Half.Life NA 2.367 hours 1compartment NA NA Rat Human -DTXSID2052283 Css NA 0.2341 mg/L 3compartmentss NA 50% Rat Human -DTXSID2052283 Css NA 1.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID2052283 Css NA 0.1952 mg/L PBTK NA 50% Rat Human -DTXSID2052283 Css NA 0.8945 mg/L PBTK NA 95% Rat Human -DTXSID2052289 Clint NA 8.546 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052289 Fup NA 0.143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052289 Vd NA 2.177 L/kg 1compartment NA NA Human Human +DTXSID2052283 TK.Half.Life NA 0.3621 hours 1compartment NA NA Rat Human +DTXSID2052283 Css NA 0.001048 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052283 Css NA 0.01275 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052283 Css NA 0.0008174 mg/L PBTK NA 50% Rat Human +DTXSID2052283 Css NA 0.008676 mg/L PBTK NA 95% Rat Human +DTXSID2052289 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052289 Fup 0.0819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052289 Vd NA 1.678 L/kg 1compartment NA NA Human Human DTXSID2052289 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2052289 TK.Half.Life NA 12.41 hours 1compartment NA NA Human Human -DTXSID2052289 Css NA 0.691 mg/L 3compartmentss NA 50% Human Human -DTXSID2052289 Css NA 4.131 mg/L 3compartmentss NA 95% Human Human -DTXSID2052289 Css NA 0.481 mg/L PBTK NA 50% Human Human -DTXSID2052289 Css NA 2.738 mg/L PBTK NA 95% Human Human -DTXSID2052289 Clint NA 8.546 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052289 Fup NA 0.143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052289 Vd NA 1.656 L/kg 1compartment NA NA Rat Human +DTXSID2052289 TK.Half.Life NA 5.757 hours 1compartment NA NA Human Human +DTXSID2052289 Css NA 0.397 mg/L 3compartmentss NA 50% Human Human +DTXSID2052289 Css NA 2.936 mg/L 3compartmentss NA 95% Human Human +DTXSID2052289 Css NA 0.2618 mg/L PBTK NA 50% Human Human +DTXSID2052289 Css NA 1.85 mg/L PBTK NA 95% Human Human +DTXSID2052289 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052289 Fup 0.0819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052289 Vd NA 1.271 L/kg 1compartment NA NA Rat Human DTXSID2052289 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2052289 TK.Half.Life NA 3.757 hours 1compartment NA NA Rat Human -DTXSID2052289 Css NA 0.3628 mg/L 3compartmentss NA 50% Rat Human -DTXSID2052289 Css NA 1.703 mg/L 3compartmentss NA 95% Rat Human -DTXSID2052289 Css NA 0.2421 mg/L PBTK NA 50% Rat Human -DTXSID2052289 Css NA 1.056 mg/L PBTK NA 95% Rat Human +DTXSID2052289 TK.Half.Life NA 2.114 hours 1compartment NA NA Rat Human +DTXSID2052289 Css NA 0.05154 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052289 Css NA 0.2945 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052289 Css NA 0.03331 mg/L PBTK NA 50% Rat Human +DTXSID2052289 Css NA 0.181 mg/L PBTK NA 95% Rat Human DTXSID2052310 Clint NA 1.582 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2052310 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2052310 Vd NA 0.7615 L/kg 1compartment NA NA Human Human DTXSID2052310 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID2052310 TK.Half.Life NA 1.587 hours 1compartment NA NA Human Human -DTXSID2052310 Css NA 0.2366 mg/L 3compartmentss NA 50% Human Human -DTXSID2052310 Css NA 1.665 mg/L 3compartmentss NA 95% Human Human -DTXSID2052310 Css NA 0.1962 mg/L PBTK NA 50% Human Human -DTXSID2052310 Css NA 1.123 mg/L PBTK NA 95% Human Human +DTXSID2052310 Css NA 0.1933 mg/L 3compartmentss NA 50% Human Human +DTXSID2052310 Css NA 1.433 mg/L 3compartmentss NA 95% Human Human +DTXSID2052310 Css NA 0.1607 mg/L PBTK NA 50% Human Human +DTXSID2052310 Css NA 0.9988 mg/L PBTK NA 95% Human Human DTXSID2052310 Clint NA 1.582 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2052310 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2052310 Vd NA 0.8012 L/kg 1compartment NA NA Rat Human DTXSID2052310 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID2052310 TK.Half.Life NA 0.8393 hours 1compartment NA NA Rat Human -DTXSID2052310 Css NA 0.09472 mg/L 3compartmentss NA 50% Rat Human -DTXSID2052310 Css NA 0.5922 mg/L 3compartmentss NA 95% Rat Human -DTXSID2052310 Css NA 0.07793 mg/L PBTK NA 50% Rat Human -DTXSID2052310 Css NA 0.3613 mg/L PBTK NA 95% Rat Human -DTXSID2052574 Clint NA 7.725 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052574 Fup NA 0.1837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052574 Vd NA 0.9847 L/kg 1compartment NA NA Human Human +DTXSID2052310 Css NA 0.005528 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052310 Css NA 0.05081 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052310 Css NA 0.004498 mg/L PBTK NA 50% Rat Human +DTXSID2052310 Css NA 0.03348 mg/L PBTK NA 95% Rat Human +DTXSID2052441 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052441 Fup 0.667 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052441 Vd NA 0.994 L/kg 1compartment NA NA Human Human +DTXSID2052441 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2052441 TK.Half.Life NA 9.965 hours 1compartment NA NA Human Human +DTXSID2052441 Css NA 1.055 mg/L 3compartmentss NA 50% Human Human +DTXSID2052441 Css NA 7.104 mg/L 3compartmentss NA 95% Human Human +DTXSID2052441 Css NA 0.9038 mg/L PBTK NA 50% Human Human +DTXSID2052441 Css NA 4.619 mg/L PBTK NA 95% Human Human +DTXSID2052441 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052441 Fup 0.667 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052441 Vd NA 0.9451 L/kg 1compartment NA NA Rat Human +DTXSID2052441 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2052441 TK.Half.Life NA 3.149 hours 1compartment NA NA Rat Human +DTXSID2052441 Css NA 0.0636 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052441 Css NA 0.406 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052441 Css NA 0.05448 mg/L PBTK NA 50% Rat Human +DTXSID2052441 Css NA 0.2531 mg/L PBTK NA 95% Rat Human +DTXSID2052491 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052491 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052491 Vd NA 0.3883 L/kg 1compartment NA NA Human Human +DTXSID2052491 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2052491 TK.Half.Life NA 5.324 hours 1compartment NA NA Human Human +DTXSID2052491 Css NA 1.383 mg/L 3compartmentss NA 50% Human Human +DTXSID2052491 Css NA 6.391 mg/L 3compartmentss NA 95% Human Human +DTXSID2052491 Css NA 0.9732 mg/L PBTK NA 50% Human Human +DTXSID2052491 Css NA 3.95 mg/L PBTK NA 95% Human Human +DTXSID2052491 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052491 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052491 Vd NA 0.4014 L/kg 1compartment NA NA Rat Human +DTXSID2052491 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2052491 TK.Half.Life NA 1.875 hours 1compartment NA NA Rat Human +DTXSID2052491 Css NA 0.0257 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052491 Css NA 0.1701 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052491 Css NA 0.01747 mg/L PBTK NA 50% Rat Human +DTXSID2052491 Css NA 0.1046 mg/L PBTK NA 95% Rat Human +DTXSID2052493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052493 Fup 0.0525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052493 Vd NA 2.797 L/kg 1compartment NA NA Human Human +DTXSID2052493 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID2052493 TK.Half.Life NA 26.02 hours 1compartment NA NA Human Human +DTXSID2052493 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human +DTXSID2052493 Css NA 7.556 mg/L 3compartmentss NA 95% Human Human +DTXSID2052493 Css NA 0.7828 mg/L PBTK NA 50% Human Human +DTXSID2052493 Css NA 4.931 mg/L PBTK NA 95% Human Human +DTXSID2052493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052493 Fup 0.0525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052493 Vd NA 2.097 L/kg 1compartment NA NA Rat Human +DTXSID2052493 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2052493 TK.Half.Life NA 5.283 hours 1compartment NA NA Rat Human +DTXSID2052493 Css NA 0.1458 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052493 Css NA 0.8126 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052493 Css NA 0.09838 mg/L PBTK NA 50% Rat Human +DTXSID2052493 Css NA 0.5317 mg/L PBTK NA 95% Rat Human +DTXSID2052574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052574 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052574 Vd NA 0.8414 L/kg 1compartment NA NA Human Human DTXSID2052574 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2052574 TK.Half.Life NA 3.32 hours 1compartment NA NA Human Human -DTXSID2052574 Css NA 0.3388 mg/L 3compartmentss NA 50% Human Human -DTXSID2052574 Css NA 2.19 mg/L 3compartmentss NA 95% Human Human -DTXSID2052574 Css NA 0.2346 mg/L PBTK NA 50% Human Human -DTXSID2052574 Css NA 1.431 mg/L PBTK NA 95% Human Human -DTXSID2052574 Clint NA 7.725 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052574 Fup NA 0.1837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052574 Vd NA 0.8084 L/kg 1compartment NA NA Rat Human +DTXSID2052574 TK.Half.Life NA 1.767 hours 1compartment NA NA Human Human +DTXSID2052574 Css NA 0.1914 mg/L 3compartmentss NA 50% Human Human +DTXSID2052574 Css NA 1.622 mg/L 3compartmentss NA 95% Human Human +DTXSID2052574 Css NA 0.1265 mg/L PBTK NA 50% Human Human +DTXSID2052574 Css NA 0.9962 mg/L PBTK NA 95% Human Human +DTXSID2052574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052574 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052574 Vd NA 0.6893 L/kg 1compartment NA NA Rat Human DTXSID2052574 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2052574 TK.Half.Life NA 1.521 hours 1compartment NA NA Rat Human -DTXSID2052574 Css NA 0.1803 mg/L 3compartmentss NA 50% Rat Human -DTXSID2052574 Css NA 0.8014 mg/L 3compartmentss NA 95% Rat Human -DTXSID2052574 Css NA 0.1191 mg/L PBTK NA 50% Rat Human -DTXSID2052574 Css NA 0.4869 mg/L PBTK NA 95% Rat Human +DTXSID2052574 TK.Half.Life NA 0.8051 hours 1compartment NA NA Rat Human +DTXSID2052574 Css NA 0.02494 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052574 Css NA 0.1562 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052574 Css NA 0.01605 mg/L PBTK NA 50% Rat Human +DTXSID2052574 Css NA 0.09355 mg/L PBTK NA 95% Rat Human +DTXSID2052578 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052578 Fup 0.00393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052578 Vd NA 11.25 L/kg 1compartment NA NA Human Human +DTXSID2052578 Days.Css NA 73 Days PBTK NA NA Human Human +DTXSID2052578 TK.Half.Life NA 344 hours 1compartment NA NA Human Human +DTXSID2052578 Css NA 1.911 mg/L 3compartmentss NA 50% Human Human +DTXSID2052578 Css NA 11.46 mg/L 3compartmentss NA 95% Human Human +DTXSID2052578 Css NA 2.449 mg/L PBTK NA 50% Human Human +DTXSID2052578 Css NA 14.18 mg/L PBTK NA 95% Human Human +DTXSID2052578 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052578 Fup 0.00393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052578 Vd NA 8.909 L/kg 1compartment NA NA Rat Human +DTXSID2052578 Days.Css NA 44 Days PBTK NA NA Rat Human +DTXSID2052578 TK.Half.Life NA 51.42 hours 1compartment NA NA Rat Human +DTXSID2052578 Css NA 0.2376 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052578 Css NA 1.107 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052578 Css NA 0.3188 mg/L PBTK NA 50% Rat Human +DTXSID2052578 Css NA 1.569 mg/L PBTK NA 95% Rat Human DTXSID2052603 Clint NA 1.539 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID2052603 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052603 Vd NA 2.471 L/kg 1compartment NA NA Human Human -DTXSID2052603 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID2052603 TK.Half.Life NA 124.1 hours 1compartment NA NA Human Human -DTXSID2052603 Css NA 6.852 mg/L 3compartmentss NA 50% Human Human -DTXSID2052603 Css NA 29.56 mg/L 3compartmentss NA 95% Human Human -DTXSID2052603 Css NA 4.684 mg/L PBTK NA 50% Human Human -DTXSID2052603 Css NA 18.83 mg/L PBTK NA 95% Human Human +DTXSID2052603 Vd NA 2.185 L/kg 1compartment NA NA Human Human +DTXSID2052603 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID2052603 TK.Half.Life NA 86.7 hours 1compartment NA NA Human Human +DTXSID2052603 Css NA 5.404 mg/L 3compartmentss NA 50% Human Human +DTXSID2052603 Css NA 24.6 mg/L 3compartmentss NA 95% Human Human +DTXSID2052603 Css NA 3.662 mg/L PBTK NA 50% Human Human +DTXSID2052603 Css NA 15.63 mg/L PBTK NA 95% Human Human DTXSID2052603 Clint NA 1.539 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID2052603 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052603 Vd NA 1.859 L/kg 1compartment NA NA Rat Human -DTXSID2052603 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID2052603 TK.Half.Life NA 26.48 hours 1compartment NA NA Rat Human -DTXSID2052603 Css NA 3.194 mg/L 3compartmentss NA 50% Rat Human -DTXSID2052603 Css NA 9.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID2052603 Css NA 2.075 mg/L PBTK NA 50% Rat Human -DTXSID2052603 Css NA 5.901 mg/L PBTK NA 95% Rat Human -DTXSID2052607 Clint NA 56.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052607 Fup NA 0.5983 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2052607 Vd NA 1.094 L/kg 1compartment NA NA Human Human +DTXSID2052603 Vd NA 1.646 L/kg 1compartment NA NA Rat Human +DTXSID2052603 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID2052603 TK.Half.Life NA 21.75 hours 1compartment NA NA Rat Human +DTXSID2052603 Css NA 0.5787 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052603 Css NA 1.947 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052603 Css NA 0.385 mg/L PBTK NA 50% Rat Human +DTXSID2052603 Css NA 1.179 mg/L PBTK NA 95% Rat Human +DTXSID2052607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052607 Fup 0.413 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052607 Vd NA 0.8811 L/kg 1compartment NA NA Human Human DTXSID2052607 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2052607 TK.Half.Life NA 0.7895 hours 1compartment NA NA Human Human -DTXSID2052607 Css NA 0.01372 mg/L 3compartmentss NA 50% Human Human -DTXSID2052607 Css NA 0.155 mg/L 3compartmentss NA 95% Human Human -DTXSID2052607 Css NA 0.01147 mg/L PBTK NA 50% Human Human -DTXSID2052607 Css NA 0.1082 mg/L PBTK NA 95% Human Human -DTXSID2052607 Clint NA 56.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052607 Fup NA 0.5983 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2052607 Vd NA 1.003 L/kg 1compartment NA NA Rat Human +DTXSID2052607 TK.Half.Life NA 0.9618 hours 1compartment NA NA Human Human +DTXSID2052607 Css NA 0.04652 mg/L 3compartmentss NA 50% Human Human +DTXSID2052607 Css NA 0.3871 mg/L 3compartmentss NA 95% Human Human +DTXSID2052607 Css NA 0.03567 mg/L PBTK NA 50% Human Human +DTXSID2052607 Css NA 0.2655 mg/L PBTK NA 95% Human Human +DTXSID2052607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052607 Fup 0.413 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052607 Vd NA 0.8054 L/kg 1compartment NA NA Rat Human DTXSID2052607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2052607 TK.Half.Life NA 0.334 hours 1compartment NA NA Rat Human -DTXSID2052607 Css NA 0.007284 mg/L 3compartmentss NA 50% Rat Human -DTXSID2052607 Css NA 0.06927 mg/L 3compartmentss NA 95% Rat Human -DTXSID2052607 Css NA 0.005924 mg/L PBTK NA 50% Rat Human -DTXSID2052607 Css NA 0.04732 mg/L PBTK NA 95% Rat Human -DTXSID2057601 Clint NA 4.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057601 Fup NA 0.0541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057601 Vd NA 0.219 L/kg 1compartment NA NA Human Human +DTXSID2052607 TK.Half.Life NA 0.4481 hours 1compartment NA NA Rat Human +DTXSID2052607 Css NA 0.005804 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052607 Css NA 0.03539 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052607 Css NA 0.004478 mg/L PBTK NA 50% Rat Human +DTXSID2052607 Css NA 0.02398 mg/L PBTK NA 95% Rat Human +DTXSID2052655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052655 Fup 0.0615 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052655 Vd NA 0.7121 L/kg 1compartment NA NA Human Human +DTXSID2052655 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2052655 TK.Half.Life NA 2.601 hours 1compartment NA NA Human Human +DTXSID2052655 Css NA 0.4946 mg/L 3compartmentss NA 50% Human Human +DTXSID2052655 Css NA 4.075 mg/L 3compartmentss NA 95% Human Human +DTXSID2052655 Css NA 0.307 mg/L PBTK NA 50% Human Human +DTXSID2052655 Css NA 2.423 mg/L PBTK NA 95% Human Human +DTXSID2052655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052655 Fup 0.0615 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052655 Vd NA 0.5649 L/kg 1compartment NA NA Rat Human +DTXSID2052655 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2052655 TK.Half.Life NA 1.227 hours 1compartment NA NA Rat Human +DTXSID2052655 Css NA 0.06462 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052655 Css NA 0.4026 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052655 Css NA 0.03881 mg/L PBTK NA 50% Rat Human +DTXSID2052655 Css NA 0.2325 mg/L PBTK NA 95% Rat Human +DTXSID2052734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052734 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052734 Vd NA 2.871 L/kg 1compartment NA NA Human Human +DTXSID2052734 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2052734 TK.Half.Life NA 9.192 hours 1compartment NA NA Human Human +DTXSID2052734 Css NA 0.2866 mg/L 3compartmentss NA 50% Human Human +DTXSID2052734 Css NA 1.788 mg/L 3compartmentss NA 95% Human Human +DTXSID2052734 Css NA 0.2084 mg/L PBTK NA 50% Human Human +DTXSID2052734 Css NA 1.254 mg/L PBTK NA 95% Human Human +DTXSID2052734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052734 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052734 Vd NA 2.18 L/kg 1compartment NA NA Rat Human +DTXSID2052734 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2052734 TK.Half.Life NA 2.027 hours 1compartment NA NA Rat Human +DTXSID2052734 Css NA 0.0357 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052734 Css NA 0.1803 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052734 Css NA 0.02604 mg/L PBTK NA 50% Rat Human +DTXSID2052734 Css NA 0.126 mg/L PBTK NA 95% Rat Human +DTXSID2052738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052738 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2052738 Vd NA 1.62 L/kg 1compartment NA NA Human Human +DTXSID2052738 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2052738 TK.Half.Life NA 2.139 hours 1compartment NA NA Human Human +DTXSID2052738 Css NA 0.0697 mg/L 3compartmentss NA 50% Human Human +DTXSID2052738 Css NA 0.5269 mg/L 3compartmentss NA 95% Human Human +DTXSID2052738 Css NA 0.05414 mg/L PBTK NA 50% Human Human +DTXSID2052738 Css NA 0.3657 mg/L PBTK NA 95% Human Human +DTXSID2052738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052738 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2052738 Vd NA 1.307 L/kg 1compartment NA NA Rat Human +DTXSID2052738 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2052738 TK.Half.Life NA 0.8281 hours 1compartment NA NA Rat Human +DTXSID2052738 Css NA 0.00883 mg/L 3compartmentss NA 50% Rat Human +DTXSID2052738 Css NA 0.05021 mg/L 3compartmentss NA 95% Rat Human +DTXSID2052738 Css NA 0.00681 mg/L PBTK NA 50% Rat Human +DTXSID2052738 Css NA 0.0348 mg/L PBTK NA 95% Rat Human +DTXSID2057576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057576 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057576 Vd NA 1.089 L/kg 1compartment NA NA Human Human +DTXSID2057576 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2057576 TK.Half.Life NA 1.964 hours 1compartment NA NA Human Human +DTXSID2057576 Css NA 0.1269 mg/L 3compartmentss NA 50% Human Human +DTXSID2057576 Css NA 0.8835 mg/L 3compartmentss NA 95% Human Human +DTXSID2057576 Css NA 0.08804 mg/L PBTK NA 50% Human Human +DTXSID2057576 Css NA 0.5764 mg/L PBTK NA 95% Human Human +DTXSID2057576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057576 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057576 Vd NA 0.8816 L/kg 1compartment NA NA Rat Human +DTXSID2057576 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2057576 TK.Half.Life NA 0.8445 hours 1compartment NA NA Rat Human +DTXSID2057576 Css NA 0.01612 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057576 Css NA 0.08412 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057576 Css NA 0.01107 mg/L PBTK NA 50% Rat Human +DTXSID2057576 Css NA 0.05466 mg/L PBTK NA 95% Rat Human +DTXSID2057601 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057601 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057601 Vd NA 0.6271 L/kg 1compartment NA NA Human Human DTXSID2057601 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057601 TK.Half.Life NA 3.531 hours 1compartment NA NA Human Human -DTXSID2057601 Css NA 2.832 mg/L 3compartmentss NA 50% Human Human -DTXSID2057601 Css NA 17.22 mg/L 3compartmentss NA 95% Human Human -DTXSID2057601 Css NA 1.689 mg/L PBTK NA 50% Human Human -DTXSID2057601 Css NA 9.968 mg/L PBTK NA 95% Human Human -DTXSID2057601 Clint NA 4.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057601 Fup NA 0.0541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057601 Vd NA 0.2135 L/kg 1compartment NA NA Rat Human +DTXSID2057601 TK.Half.Life NA 1.916 hours 1compartment NA NA Human Human +DTXSID2057601 Css NA 0.2858 mg/L 3compartmentss NA 50% Human Human +DTXSID2057601 Css NA 1.701 mg/L 3compartmentss NA 95% Human Human +DTXSID2057601 Css NA 0.1979 mg/L PBTK NA 50% Human Human +DTXSID2057601 Css NA 1.108 mg/L PBTK NA 95% Human Human +DTXSID2057601 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057601 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057601 Vd NA 0.5751 L/kg 1compartment NA NA Rat Human DTXSID2057601 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057601 TK.Half.Life NA 2.083 hours 1compartment NA NA Rat Human -DTXSID2057601 Css NA 1.426 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057601 Css NA 6.885 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057601 Css NA 0.7934 mg/L PBTK NA 50% Rat Human -DTXSID2057601 Css NA 3.744 mg/L PBTK NA 95% Rat Human -DTXSID2057603 Clint NA 16.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057603 Fup NA 0.6651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057603 Vd NA 1.179 L/kg 1compartment NA NA Human Human +DTXSID2057601 TK.Half.Life NA 1.01 hours 1compartment NA NA Rat Human +DTXSID2057601 Css NA 0.03408 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057601 Css NA 0.1495 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057601 Css NA 0.02327 mg/L PBTK NA 50% Rat Human +DTXSID2057601 Css NA 0.09363 mg/L PBTK NA 95% Rat Human +DTXSID2057603 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057603 Fup 0.518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057603 Vd NA 1.191 L/kg 1compartment NA NA Human Human DTXSID2057603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057603 TK.Half.Life NA 1.102 hours 1compartment NA NA Human Human -DTXSID2057603 Css NA 0.04401 mg/L 3compartmentss NA 50% Human Human -DTXSID2057603 Css NA 0.4236 mg/L 3compartmentss NA 95% Human Human -DTXSID2057603 Css NA 0.03706 mg/L PBTK NA 50% Human Human -DTXSID2057603 Css NA 0.2977 mg/L PBTK NA 95% Human Human -DTXSID2057603 Clint NA 16.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057603 Fup NA 0.6651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057603 Vd NA 1.061 L/kg 1compartment NA NA Rat Human +DTXSID2057603 TK.Half.Life NA 2.059 hours 1compartment NA NA Human Human +DTXSID2057603 Css NA 0.1114 mg/L 3compartmentss NA 50% Human Human +DTXSID2057603 Css NA 0.8802 mg/L 3compartmentss NA 95% Human Human +DTXSID2057603 Css NA 0.09042 mg/L PBTK NA 50% Human Human +DTXSID2057603 Css NA 0.6116 mg/L PBTK NA 95% Human Human +DTXSID2057603 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057603 Fup 0.518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057603 Vd NA 1.038 L/kg 1compartment NA NA Rat Human DTXSID2057603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057603 TK.Half.Life NA 0.4906 hours 1compartment NA NA Rat Human -DTXSID2057603 Css NA 0.02204 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057603 Css NA 0.1924 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057603 Css NA 0.01822 mg/L PBTK NA 50% Rat Human -DTXSID2057603 Css NA 0.1259 mg/L PBTK NA 95% Rat Human -DTXSID2057609 Clint NA 12.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057609 Fup NA 0.1326 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057609 Vd NA 0.4609 L/kg 1compartment NA NA Human Human +DTXSID2057603 TK.Half.Life NA 0.9369 hours 1compartment NA NA Rat Human +DTXSID2057603 Css NA 0.00476 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057603 Css NA 0.04406 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057603 Css NA 0.00393 mg/L PBTK NA 50% Rat Human +DTXSID2057603 Css NA 0.02991 mg/L PBTK NA 95% Rat Human +DTXSID2057609 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057609 Fup 0.624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057609 Vd NA 1.08 L/kg 1compartment NA NA Human Human DTXSID2057609 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057609 TK.Half.Life NA 1.393 hours 1compartment NA NA Human Human -DTXSID2057609 Css NA 0.3549 mg/L 3compartmentss NA 50% Human Human -DTXSID2057609 Css NA 2.8 mg/L 3compartmentss NA 95% Human Human -DTXSID2057609 Css NA 0.2267 mg/L PBTK NA 50% Human Human -DTXSID2057609 Css NA 1.693 mg/L PBTK NA 95% Human Human -DTXSID2057609 Clint NA 12.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057609 Fup NA 0.1326 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057609 Vd NA 0.4219 L/kg 1compartment NA NA Rat Human +DTXSID2057609 TK.Half.Life NA 1.572 hours 1compartment NA NA Human Human +DTXSID2057609 Css NA 0.1046 mg/L 3compartmentss NA 50% Human Human +DTXSID2057609 Css NA 0.9768 mg/L 3compartmentss NA 95% Human Human +DTXSID2057609 Css NA 0.08812 mg/L PBTK NA 50% Human Human +DTXSID2057609 Css NA 0.6529 mg/L PBTK NA 95% Human Human +DTXSID2057609 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057609 Fup 0.624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057609 Vd NA 0.9991 L/kg 1compartment NA NA Rat Human DTXSID2057609 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057609 TK.Half.Life NA 0.7575 hours 1compartment NA NA Rat Human -DTXSID2057609 Css NA 0.1957 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057609 Css NA 1.123 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057609 Css NA 0.1174 mg/L PBTK NA 50% Rat Human -DTXSID2057609 Css NA 0.6359 mg/L PBTK NA 95% Rat Human -DTXSID2057651 Clint NA 73.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057651 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057651 Vd NA 2.708 L/kg 1compartment NA NA Human Human -DTXSID2057651 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057651 TK.Half.Life NA 8.599 hours 1compartment NA NA Human Human -DTXSID2057651 Css NA 0.3288 mg/L 3compartmentss NA 50% Human Human -DTXSID2057651 Css NA 2.355 mg/L 3compartmentss NA 95% Human Human -DTXSID2057651 Css NA 0.2246 mg/L PBTK NA 50% Human Human -DTXSID2057651 Css NA 1.556 mg/L PBTK NA 95% Human Human -DTXSID2057651 Clint NA 73.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057651 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057651 Vd NA 2.031 L/kg 1compartment NA NA Rat Human +DTXSID2057609 TK.Half.Life NA 0.7692 hours 1compartment NA NA Rat Human +DTXSID2057609 Css NA 0.01176 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057609 Css NA 0.09011 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057609 Css NA 0.01006 mg/L PBTK NA 50% Rat Human +DTXSID2057609 Css NA 0.05752 mg/L PBTK NA 95% Rat Human +DTXSID2057651 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057651 Fup 0.0179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057651 Vd NA 1.7 L/kg 1compartment NA NA Human Human +DTXSID2057651 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2057651 TK.Half.Life NA 17.47 hours 1compartment NA NA Human Human +DTXSID2057651 Css NA 1.564 mg/L 3compartmentss NA 50% Human Human +DTXSID2057651 Css NA 13.26 mg/L 3compartmentss NA 95% Human Human +DTXSID2057651 Css NA 0.992 mg/L PBTK NA 50% Human Human +DTXSID2057651 Css NA 8.155 mg/L PBTK NA 95% Human Human +DTXSID2057651 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057651 Fup 0.0179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057651 Vd NA 1.262 L/kg 1compartment NA NA Rat Human DTXSID2057651 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057651 TK.Half.Life NA 2.068 hours 1compartment NA NA Rat Human -DTXSID2057651 Css NA 0.1866 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057651 Css NA 1.038 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057651 Css NA 0.1211 mg/L PBTK NA 50% Rat Human -DTXSID2057651 Css NA 0.6526 mg/L PBTK NA 95% Rat Human -DTXSID2057653 Clint NA 16.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057653 Fup NA 0.0844 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057653 Vd NA 1.205 L/kg 1compartment NA NA Human Human +DTXSID2057651 TK.Half.Life NA 6.319 hours 1compartment NA NA Rat Human +DTXSID2057651 Css NA 0.2037 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057651 Css NA 1.455 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057651 Css NA 0.1254 mg/L PBTK NA 50% Rat Human +DTXSID2057651 Css NA 0.8523 mg/L PBTK NA 95% Rat Human +DTXSID2057653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057653 Fup 0.0927 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057653 Vd NA 1.989 L/kg 1compartment NA NA Human Human DTXSID2057653 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057653 TK.Half.Life NA 4.407 hours 1compartment NA NA Human Human -DTXSID2057653 Css NA 0.463 mg/L 3compartmentss NA 50% Human Human -DTXSID2057653 Css NA 3.448 mg/L 3compartmentss NA 95% Human Human -DTXSID2057653 Css NA 0.2996 mg/L PBTK NA 50% Human Human -DTXSID2057653 Css NA 2.133 mg/L PBTK NA 95% Human Human -DTXSID2057653 Clint NA 16.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057653 Fup NA 0.0844 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057653 Vd NA 0.9283 L/kg 1compartment NA NA Rat Human +DTXSID2057653 TK.Half.Life NA 6.918 hours 1compartment NA NA Human Human +DTXSID2057653 Css NA 0.3916 mg/L 3compartmentss NA 50% Human Human +DTXSID2057653 Css NA 2.73 mg/L 3compartmentss NA 95% Human Human +DTXSID2057653 Css NA 0.2641 mg/L PBTK NA 50% Human Human +DTXSID2057653 Css NA 1.742 mg/L PBTK NA 95% Human Human +DTXSID2057653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057653 Fup 0.0927 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057653 Vd NA 1.505 L/kg 1compartment NA NA Rat Human DTXSID2057653 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057653 TK.Half.Life NA 1.851 hours 1compartment NA NA Rat Human -DTXSID2057653 Css NA 0.2598 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057653 Css NA 1.499 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057653 Css NA 0.1584 mg/L PBTK NA 50% Rat Human -DTXSID2057653 Css NA 0.8783 mg/L PBTK NA 95% Rat Human -DTXSID2057655 Clint NA 24.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057655 Fup NA 0.3642 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057655 Vd NA 2.08 L/kg 1compartment NA NA Human Human +DTXSID2057653 TK.Half.Life NA 2.303 hours 1compartment NA NA Rat Human +DTXSID2057653 Css NA 0.05006 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057653 Css NA 0.2984 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057653 Css NA 0.03314 mg/L PBTK NA 50% Rat Human +DTXSID2057653 Css NA 0.1862 mg/L PBTK NA 95% Rat Human +DTXSID2057655 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057655 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057655 Vd NA 0.4021 L/kg 1compartment NA NA Human Human DTXSID2057655 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057655 TK.Half.Life NA 2.673 hours 1compartment NA NA Human Human -DTXSID2057655 Css NA 0.07063 mg/L 3compartmentss NA 50% Human Human -DTXSID2057655 Css NA 0.4743 mg/L 3compartmentss NA 95% Human Human -DTXSID2057655 Css NA 0.05581 mg/L PBTK NA 50% Human Human -DTXSID2057655 Css NA 0.3483 mg/L PBTK NA 95% Human Human -DTXSID2057655 Clint NA 24.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057655 Fup NA 0.3642 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057655 Vd NA 1.676 L/kg 1compartment NA NA Rat Human +DTXSID2057655 TK.Half.Life NA 1.082 hours 1compartment NA NA Human Human +DTXSID2057655 Css NA 0.1302 mg/L 3compartmentss NA 50% Human Human +DTXSID2057655 Css NA 0.8866 mg/L 3compartmentss NA 95% Human Human +DTXSID2057655 Css NA 0.0865 mg/L PBTK NA 50% Human Human +DTXSID2057655 Css NA 0.5521 mg/L PBTK NA 95% Human Human +DTXSID2057655 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057655 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057655 Vd NA 0.4073 L/kg 1compartment NA NA Rat Human DTXSID2057655 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057655 TK.Half.Life NA 0.9608 hours 1compartment NA NA Rat Human -DTXSID2057655 Css NA 0.03786 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057655 Css NA 0.2059 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057655 Css NA 0.02912 mg/L PBTK NA 50% Rat Human -DTXSID2057655 Css NA 0.1435 mg/L PBTK NA 95% Rat Human -DTXSID2057657 Clint NA 8.177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057657 Fup NA 0.5632 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057657 Vd NA 4.086 L/kg 1compartment NA NA Human Human +DTXSID2057655 TK.Half.Life NA 0.6256 hours 1compartment NA NA Rat Human +DTXSID2057655 Css NA 0.001241 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057655 Css NA 0.00736 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057655 Css NA 0.0007904 mg/L PBTK NA 50% Rat Human +DTXSID2057655 Css NA 0.004353 mg/L PBTK NA 95% Rat Human +DTXSID2057657 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057657 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057657 Vd NA 3.201 L/kg 1compartment NA NA Human Human DTXSID2057657 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057657 TK.Half.Life NA 6.822 hours 1compartment NA NA Human Human -DTXSID2057657 Css NA 0.1061 mg/L 3compartmentss NA 50% Human Human -DTXSID2057657 Css NA 0.8856 mg/L 3compartmentss NA 95% Human Human -DTXSID2057657 Css NA 0.1195 mg/L PBTK NA 50% Human Human -DTXSID2057657 Css NA 0.7513 mg/L PBTK NA 95% Human Human -DTXSID2057657 Clint NA 8.177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057657 Fup NA 0.5632 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057657 Vd NA 3.792 L/kg 1compartment NA NA Rat Human +DTXSID2057657 TK.Half.Life NA 7.622 hours 1compartment NA NA Human Human +DTXSID2057657 Css NA 0.1622 mg/L 3compartmentss NA 50% Human Human +DTXSID2057657 Css NA 1.055 mg/L 3compartmentss NA 95% Human Human +DTXSID2057657 Css NA 0.1652 mg/L PBTK NA 50% Human Human +DTXSID2057657 Css NA 0.8964 mg/L PBTK NA 95% Human Human +DTXSID2057657 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057657 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057657 Vd NA 2.998 L/kg 1compartment NA NA Rat Human DTXSID2057657 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057657 TK.Half.Life NA 2.624 hours 1compartment NA NA Rat Human -DTXSID2057657 Css NA 0.0531 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057657 Css NA 0.3564 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057657 Css NA 0.05944 mg/L PBTK NA 50% Rat Human -DTXSID2057657 Css NA 0.288 mg/L PBTK NA 95% Rat Human -DTXSID2057659 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057659 Fup NA 0.7995 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057659 Vd NA 0.67 L/kg 1compartment NA NA Human Human +DTXSID2057657 TK.Half.Life NA 3.474 hours 1compartment NA NA Rat Human +DTXSID2057657 Css NA 0.01874 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057657 Css NA 0.09379 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057657 Css NA 0.01951 mg/L PBTK NA 50% Rat Human +DTXSID2057657 Css NA 0.07791 mg/L PBTK NA 95% Rat Human +DTXSID2057659 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057659 Fup 0.818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057659 Vd NA 0.6076 L/kg 1compartment NA NA Human Human DTXSID2057659 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057659 TK.Half.Life NA 5.424 hours 1compartment NA NA Human Human -DTXSID2057659 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human -DTXSID2057659 Css NA 5.851 mg/L 3compartmentss NA 95% Human Human -DTXSID2057659 Css NA 0.8153 mg/L PBTK NA 50% Human Human -DTXSID2057659 Css NA 3.815 mg/L PBTK NA 95% Human Human -DTXSID2057659 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057659 Fup NA 0.7995 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057659 Vd NA 0.7029 L/kg 1compartment NA NA Rat Human +DTXSID2057659 TK.Half.Life NA 4.807 hours 1compartment NA NA Human Human +DTXSID2057659 Css NA 0.5622 mg/L 3compartmentss NA 50% Human Human +DTXSID2057659 Css NA 3.404 mg/L 3compartmentss NA 95% Human Human +DTXSID2057659 Css NA 0.4402 mg/L PBTK NA 50% Human Human +DTXSID2057659 Css NA 2.174 mg/L PBTK NA 95% Human Human +DTXSID2057659 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057659 Fup 0.818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057659 Vd NA 0.6336 L/kg 1compartment NA NA Rat Human DTXSID2057659 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057659 TK.Half.Life NA 1.939 hours 1compartment NA NA Rat Human -DTXSID2057659 Css NA 0.2608 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057659 Css NA 1.488 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057659 Css NA 0.2034 mg/L PBTK NA 50% Rat Human -DTXSID2057659 Css NA 0.8854 mg/L PBTK NA 95% Rat Human -DTXSID2057730 Clint NA 30.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057730 Fup NA 0.02 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057730 Vd NA 118.5 L/kg 1compartment NA NA Human Human -DTXSID2057730 Days.Css NA 637 Days PBTK NA NA Human Human -DTXSID2057730 TK.Half.Life NA 2452 hours 1compartment NA NA Human Human -DTXSID2057730 Css NA 0.1152 mg/L 3compartmentss NA 50% Human Human -DTXSID2057730 Css NA 0.722 mg/L 3compartmentss NA 95% Human Human -DTXSID2057730 Css NA 1.702 mg/L PBTK NA 50% Human Human -DTXSID2057730 Css NA 9.403 mg/L PBTK NA 95% Human Human -DTXSID2057730 Clint NA 30.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057730 Fup NA 0.02 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057730 Vd NA 103 L/kg 1compartment NA NA Rat Human -DTXSID2057730 Days.Css NA 404 Days PBTK NA NA Rat Human -DTXSID2057730 TK.Half.Life NA 365.4 hours 1compartment NA NA Rat Human -DTXSID2057730 Css NA 0.05946 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057730 Css NA 0.2581 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057730 Css NA 0.9248 mg/L PBTK NA 50% Rat Human -DTXSID2057730 Css NA 3.971 mg/L PBTK NA 95% Rat Human -DTXSID2057732 Clint NA 3.218 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057732 Fup NA 0.3009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057732 Vd NA 0.6471 L/kg 1compartment NA NA Human Human +DTXSID2057659 TK.Half.Life NA 1.708 hours 1compartment NA NA Rat Human +DTXSID2057659 Css NA 0.002898 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057659 Css NA 0.01863 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057659 Css NA 0.002188 mg/L PBTK NA 50% Rat Human +DTXSID2057659 Css NA 0.01135 mg/L PBTK NA 95% Rat Human +DTXSID2057730 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057730 Fup 0.0227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057730 Vd NA 14.57 L/kg 1compartment NA NA Human Human +DTXSID2057730 Days.Css NA 95 Days PBTK NA NA Human Human +DTXSID2057730 TK.Half.Life NA 432.1 hours 1compartment NA NA Human Human +DTXSID2057730 Css NA 1.481 mg/L 3compartmentss NA 50% Human Human +DTXSID2057730 Css NA 9.389 mg/L 3compartmentss NA 95% Human Human +DTXSID2057730 Css NA 2.361 mg/L PBTK NA 50% Human Human +DTXSID2057730 Css NA 14.59 mg/L PBTK NA 95% Human Human +DTXSID2057730 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057730 Fup 0.0227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057730 Vd NA 11.67 L/kg 1compartment NA NA Rat Human +DTXSID2057730 Days.Css NA 57 Days PBTK NA NA Rat Human +DTXSID2057730 TK.Half.Life NA 60.06 hours 1compartment NA NA Rat Human +DTXSID2057730 Css NA 0.1826 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057730 Css NA 0.9066 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057730 Css NA 0.3074 mg/L PBTK NA 50% Rat Human +DTXSID2057730 Css NA 1.554 mg/L PBTK NA 95% Rat Human +DTXSID2057732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057732 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057732 Vd NA 0.8136 L/kg 1compartment NA NA Human Human DTXSID2057732 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057732 TK.Half.Life NA 2.563 hours 1compartment NA NA Human Human -DTXSID2057732 Css NA 0.4085 mg/L 3compartmentss NA 50% Human Human -DTXSID2057732 Css NA 2.208 mg/L 3compartmentss NA 95% Human Human -DTXSID2057732 Css NA 0.2948 mg/L PBTK NA 50% Human Human -DTXSID2057732 Css NA 1.427 mg/L PBTK NA 95% Human Human -DTXSID2057732 Clint NA 3.218 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057732 Fup NA 0.3009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057732 Vd NA 0.6053 L/kg 1compartment NA NA Rat Human +DTXSID2057732 TK.Half.Life NA 0.9921 hours 1compartment NA NA Human Human +DTXSID2057732 Css NA 0.05836 mg/L 3compartmentss NA 50% Human Human +DTXSID2057732 Css NA 0.4587 mg/L 3compartmentss NA 95% Human Human +DTXSID2057732 Css NA 0.04294 mg/L PBTK NA 50% Human Human +DTXSID2057732 Css NA 0.3073 mg/L PBTK NA 95% Human Human +DTXSID2057732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057732 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057732 Vd NA 0.7356 L/kg 1compartment NA NA Rat Human DTXSID2057732 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057732 TK.Half.Life NA 1.335 hours 1compartment NA NA Rat Human -DTXSID2057732 Css NA 0.1957 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057732 Css NA 0.7898 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057732 Css NA 0.1349 mg/L PBTK NA 50% Rat Human -DTXSID2057732 Css NA 0.4775 mg/L PBTK NA 95% Rat Human -DTXSID2057734 Clint NA 24.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057734 Fup NA 0.5176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057734 Vd NA 1.995 L/kg 1compartment NA NA Human Human +DTXSID2057732 TK.Half.Life NA 0.4655 hours 1compartment NA NA Rat Human +DTXSID2057732 Css NA 0.007395 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057732 Css NA 0.04269 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057732 Css NA 0.005468 mg/L PBTK NA 50% Rat Human +DTXSID2057732 Css NA 0.0291 mg/L PBTK NA 95% Rat Human +DTXSID2057734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057734 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057734 Vd NA 1.888 L/kg 1compartment NA NA Human Human DTXSID2057734 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057734 TK.Half.Life NA 2.022 hours 1compartment NA NA Human Human -DTXSID2057734 Css NA 0.04496 mg/L 3compartmentss NA 50% Human Human -DTXSID2057734 Css NA 0.3452 mg/L 3compartmentss NA 95% Human Human -DTXSID2057734 Css NA 0.03793 mg/L PBTK NA 50% Human Human -DTXSID2057734 Css NA 0.2563 mg/L PBTK NA 95% Human Human -DTXSID2057734 Clint NA 24.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057734 Fup NA 0.5176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057734 Vd NA 1.639 L/kg 1compartment NA NA Rat Human +DTXSID2057734 TK.Half.Life NA 2.129 hours 1compartment NA NA Human Human +DTXSID2057734 Css NA 0.05224 mg/L 3compartmentss NA 50% Human Human +DTXSID2057734 Css NA 0.4277 mg/L 3compartmentss NA 95% Human Human +DTXSID2057734 Css NA 0.0431 mg/L PBTK NA 50% Human Human +DTXSID2057734 Css NA 0.3111 mg/L PBTK NA 95% Human Human +DTXSID2057734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057734 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057734 Vd NA 1.549 L/kg 1compartment NA NA Rat Human DTXSID2057734 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057734 TK.Half.Life NA 0.7499 hours 1compartment NA NA Rat Human -DTXSID2057734 Css NA 0.02375 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057734 Css NA 0.1557 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057734 Css NA 0.01952 mg/L PBTK NA 50% Rat Human -DTXSID2057734 Css NA 0.1072 mg/L PBTK NA 95% Rat Human -DTXSID2057736 Clint NA 2.599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057736 Fup NA 0.3109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057736 Vd NA 0.3452 L/kg 1compartment NA NA Human Human +DTXSID2057734 TK.Half.Life NA 0.8054 hours 1compartment NA NA Rat Human +DTXSID2057734 Css NA 0.006472 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057734 Css NA 0.04054 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057734 Css NA 0.0054 mg/L PBTK NA 50% Rat Human +DTXSID2057734 Css NA 0.02941 mg/L PBTK NA 95% Rat Human +DTXSID2057736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057736 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057736 Vd NA 0.3801 L/kg 1compartment NA NA Human Human DTXSID2057736 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057736 TK.Half.Life NA 1.544 hours 1compartment NA NA Human Human -DTXSID2057736 Css NA 0.4992 mg/L 3compartmentss NA 50% Human Human -DTXSID2057736 Css NA 2.627 mg/L 3compartmentss NA 95% Human Human -DTXSID2057736 Css NA 0.3325 mg/L PBTK NA 50% Human Human -DTXSID2057736 Css NA 1.632 mg/L PBTK NA 95% Human Human -DTXSID2057736 Clint NA 2.599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057736 Fup NA 0.3109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057736 Vd NA 0.3482 L/kg 1compartment NA NA Rat Human +DTXSID2057736 TK.Half.Life NA 0.4618 hours 1compartment NA NA Human Human +DTXSID2057736 Css NA 0.05632 mg/L 3compartmentss NA 50% Human Human +DTXSID2057736 Css NA 0.4293 mg/L 3compartmentss NA 95% Human Human +DTXSID2057736 Css NA 0.0383 mg/L PBTK NA 50% Human Human +DTXSID2057736 Css NA 0.276 mg/L PBTK NA 95% Human Human +DTXSID2057736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057736 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057736 Vd NA 0.3841 L/kg 1compartment NA NA Rat Human DTXSID2057736 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057736 TK.Half.Life NA 0.8576 hours 1compartment NA NA Rat Human -DTXSID2057736 Css NA 0.2374 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057736 Css NA 0.9207 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057736 Css NA 0.1497 mg/L PBTK NA 50% Rat Human -DTXSID2057736 Css NA 0.5317 mg/L PBTK NA 95% Rat Human -DTXSID2057738 Clint NA 3.208 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057738 Fup NA 0.8285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057738 Vd NA 2.906 L/kg 1compartment NA NA Human Human -DTXSID2057738 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057738 TK.Half.Life NA 4.393 hours 1compartment NA NA Human Human -DTXSID2057738 Css NA 0.1152 mg/L 3compartmentss NA 50% Human Human -DTXSID2057738 Css NA 0.9982 mg/L 3compartmentss NA 95% Human Human -DTXSID2057738 Css NA 0.1339 mg/L PBTK NA 50% Human Human -DTXSID2057738 Css NA 0.7892 mg/L PBTK NA 95% Human Human -DTXSID2057738 Clint NA 3.208 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057738 Fup NA 0.8285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057738 Vd NA 2.935 L/kg 1compartment NA NA Rat Human -DTXSID2057738 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057738 TK.Half.Life NA 2.433 hours 1compartment NA NA Rat Human -DTXSID2057738 Css NA 0.04918 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057738 Css NA 0.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057738 Css NA 0.0583 mg/L PBTK NA 50% Rat Human -DTXSID2057738 Css NA 0.2958 mg/L PBTK NA 95% Rat Human -DTXSID2057782 Clint NA 7.355 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057782 Fup NA 0.1017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057782 Vd NA 0.2379 L/kg 1compartment NA NA Human Human +DTXSID2057736 TK.Half.Life NA 0.2398 hours 1compartment NA NA Rat Human +DTXSID2057736 Css NA 0.007017 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057736 Css NA 0.03986 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057736 Css NA 0.004759 mg/L PBTK NA 50% Rat Human +DTXSID2057736 Css NA 0.02515 mg/L PBTK NA 95% Rat Human +DTXSID2057738 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057738 Fup 0.436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057738 Vd NA 2.132 L/kg 1compartment NA NA Human Human +DTXSID2057738 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID2057738 TK.Half.Life NA 31.65 hours 1compartment NA NA Human Human +DTXSID2057738 Css NA 1.184 mg/L 3compartmentss NA 50% Human Human +DTXSID2057738 Css NA 6.474 mg/L 3compartmentss NA 95% Human Human +DTXSID2057738 Css NA 1.196 mg/L PBTK NA 50% Human Human +DTXSID2057738 Css NA 4.689 mg/L PBTK NA 95% Human Human +DTXSID2057738 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057738 Fup 0.436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057738 Vd NA 2.137 L/kg 1compartment NA NA Rat Human +DTXSID2057738 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID2057738 TK.Half.Life NA 10.8 hours 1compartment NA NA Rat Human +DTXSID2057738 Css NA 0.07461 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057738 Css NA 0.3575 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057738 Css NA 0.07594 mg/L PBTK NA 50% Rat Human +DTXSID2057738 Css NA 0.2501 mg/L PBTK NA 95% Rat Human +DTXSID2057782 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057782 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057782 Vd NA 0.3115 L/kg 1compartment NA NA Human Human DTXSID2057782 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057782 TK.Half.Life NA 1.338 hours 1compartment NA NA Human Human -DTXSID2057782 Css NA 0.848 mg/L 3compartmentss NA 50% Human Human -DTXSID2057782 Css NA 5.765 mg/L 3compartmentss NA 95% Human Human -DTXSID2057782 Css NA 0.5108 mg/L PBTK NA 50% Human Human -DTXSID2057782 Css NA 3.408 mg/L PBTK NA 95% Human Human -DTXSID2057782 Clint NA 7.355 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057782 Fup NA 0.1017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057782 Vd NA 0.2373 L/kg 1compartment NA NA Rat Human +DTXSID2057782 TK.Half.Life NA 1.033 hours 1compartment NA NA Human Human +DTXSID2057782 Css NA 0.3374 mg/L 3compartmentss NA 50% Human Human +DTXSID2057782 Css NA 2.01 mg/L 3compartmentss NA 95% Human Human +DTXSID2057782 Css NA 0.2167 mg/L PBTK NA 50% Human Human +DTXSID2057782 Css NA 1.231 mg/L PBTK NA 95% Human Human +DTXSID2057782 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057782 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057782 Vd NA 0.3129 L/kg 1compartment NA NA Rat Human DTXSID2057782 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057782 TK.Half.Life NA 0.8155 hours 1compartment NA NA Rat Human -DTXSID2057782 Css NA 0.4436 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057782 Css NA 2.294 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057782 Css NA 0.2515 mg/L PBTK NA 50% Rat Human -DTXSID2057782 Css NA 1.255 mg/L PBTK NA 95% Rat Human -DTXSID2057784 Clint NA 28.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057784 Fup NA 0.4081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057784 Vd NA 0.5385 L/kg 1compartment NA NA Human Human +DTXSID2057782 TK.Half.Life NA 0.6033 hours 1compartment NA NA Rat Human +DTXSID2057782 Css NA 0.04052 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057782 Css NA 0.1747 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057782 Css NA 0.0255 mg/L PBTK NA 50% Rat Human +DTXSID2057782 Css NA 0.105 mg/L PBTK NA 95% Rat Human +DTXSID2057784 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057784 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057784 Vd NA 0.7302 L/kg 1compartment NA NA Human Human DTXSID2057784 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057784 TK.Half.Life NA 0.5603 hours 1compartment NA NA Human Human -DTXSID2057784 Css NA 0.04094 mg/L 3compartmentss NA 50% Human Human -DTXSID2057784 Css NA 0.3219 mg/L 3compartmentss NA 95% Human Human -DTXSID2057784 Css NA 0.02992 mg/L PBTK NA 50% Human Human -DTXSID2057784 Css NA 0.2146 mg/L PBTK NA 95% Human Human -DTXSID2057784 Clint NA 28.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057784 Fup NA 0.4081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057784 Vd NA 0.5464 L/kg 1compartment NA NA Rat Human +DTXSID2057784 TK.Half.Life NA 0.7447 hours 1compartment NA NA Human Human +DTXSID2057784 Css NA 0.03993 mg/L 3compartmentss NA 50% Human Human +DTXSID2057784 Css NA 0.3657 mg/L 3compartmentss NA 95% Human Human +DTXSID2057784 Css NA 0.03085 mg/L PBTK NA 50% Human Human +DTXSID2057784 Css NA 0.2567 mg/L PBTK NA 95% Human Human +DTXSID2057784 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057784 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057784 Vd NA 0.7091 L/kg 1compartment NA NA Rat Human DTXSID2057784 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057784 TK.Half.Life NA 0.2854 hours 1compartment NA NA Rat Human -DTXSID2057784 Css NA 0.02178 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057784 Css NA 0.1348 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057784 Css NA 0.01515 mg/L PBTK NA 50% Rat Human -DTXSID2057784 Css NA 0.08481 mg/L PBTK NA 95% Rat Human -DTXSID2057811 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057811 Fup NA 0.6024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057811 Vd NA 0.3817 L/kg 1compartment NA NA Human Human +DTXSID2057784 TK.Half.Life NA 0.366 hours 1compartment NA NA Rat Human +DTXSID2057784 Css NA 0.004984 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057784 Css NA 0.0347 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057784 Css NA 0.00386 mg/L PBTK NA 50% Rat Human +DTXSID2057784 Css NA 0.02296 mg/L PBTK NA 95% Rat Human +DTXSID2057811 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057811 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057811 Vd NA 0.4121 L/kg 1compartment NA NA Human Human DTXSID2057811 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057811 TK.Half.Life NA 4.099 hours 1compartment NA NA Human Human -DTXSID2057811 Css NA 1.384 mg/L 3compartmentss NA 50% Human Human -DTXSID2057811 Css NA 8.797 mg/L 3compartmentss NA 95% Human Human -DTXSID2057811 Css NA 0.9774 mg/L PBTK NA 50% Human Human -DTXSID2057811 Css NA 5.35 mg/L PBTK NA 95% Human Human -DTXSID2057811 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057811 Fup NA 0.6024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057811 Vd NA 0.3996 L/kg 1compartment NA NA Rat Human +DTXSID2057811 TK.Half.Life NA 3.853 hours 1compartment NA NA Human Human +DTXSID2057811 Css NA 1.205 mg/L 3compartmentss NA 50% Human Human +DTXSID2057811 Css NA 7.168 mg/L 3compartmentss NA 95% Human Human +DTXSID2057811 Css NA 0.8705 mg/L PBTK NA 50% Human Human +DTXSID2057811 Css NA 4.423 mg/L PBTK NA 95% Human Human +DTXSID2057811 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057811 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057811 Vd NA 0.4316 L/kg 1compartment NA NA Rat Human DTXSID2057811 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057811 TK.Half.Life NA 1.462 hours 1compartment NA NA Rat Human -DTXSID2057811 Css NA 0.372 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057811 Css NA 2.133 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057811 Css NA 0.2494 mg/L PBTK NA 50% Rat Human -DTXSID2057811 Css NA 1.209 mg/L PBTK NA 95% Rat Human -DTXSID2057813 Clint NA 15.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057813 Fup NA 0.343 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057813 Vd NA 0.7603 L/kg 1compartment NA NA Human Human +DTXSID2057811 TK.Half.Life NA 1.375 hours 1compartment NA NA Rat Human +DTXSID2057811 Css NA 0.07247 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057811 Css NA 0.417 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057811 Css NA 0.05168 mg/L PBTK NA 50% Rat Human +DTXSID2057811 Css NA 0.2466 mg/L PBTK NA 95% Rat Human +DTXSID2057813 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057813 Fup 0.618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057813 Vd NA 0.9359 L/kg 1compartment NA NA Human Human DTXSID2057813 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057813 TK.Half.Life NA 1.048 hours 1compartment NA NA Human Human -DTXSID2057813 Css NA 0.08372 mg/L 3compartmentss NA 50% Human Human -DTXSID2057813 Css NA 0.5745 mg/L 3compartmentss NA 95% Human Human -DTXSID2057813 Css NA 0.06174 mg/L PBTK NA 50% Human Human -DTXSID2057813 Css NA 0.3897 mg/L PBTK NA 95% Human Human -DTXSID2057813 Clint NA 15.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057813 Fup NA 0.343 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057813 Vd NA 0.7023 L/kg 1compartment NA NA Rat Human +DTXSID2057813 TK.Half.Life NA 1.363 hours 1compartment NA NA Human Human +DTXSID2057813 Css NA 0.1068 mg/L 3compartmentss NA 50% Human Human +DTXSID2057813 Css NA 1.007 mg/L 3compartmentss NA 95% Human Human +DTXSID2057813 Css NA 0.08794 mg/L PBTK NA 50% Human Human +DTXSID2057813 Css NA 0.6773 mg/L PBTK NA 95% Human Human +DTXSID2057813 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057813 Fup 0.618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057813 Vd NA 0.8947 L/kg 1compartment NA NA Rat Human DTXSID2057813 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057813 TK.Half.Life NA 0.5165 hours 1compartment NA NA Rat Human -DTXSID2057813 Css NA 0.04429 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057813 Css NA 0.2429 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057813 Css NA 0.03138 mg/L PBTK NA 50% Rat Human -DTXSID2057813 Css NA 0.1542 mg/L PBTK NA 95% Rat Human -DTXSID2057815 Clint NA 4.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057815 Fup NA 0.0288 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057815 Vd NA 2.034 L/kg 1compartment NA NA Human Human -DTXSID2057815 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID2057815 TK.Half.Life NA 66.33 hours 1compartment NA NA Human Human -DTXSID2057815 Css NA 5.092 mg/L 3compartmentss NA 50% Human Human -DTXSID2057815 Css NA 35.42 mg/L 3compartmentss NA 95% Human Human -DTXSID2057815 Css NA 3.367 mg/L PBTK NA 50% Human Human -DTXSID2057815 Css NA 22.05 mg/L PBTK NA 95% Human Human -DTXSID2057815 Clint NA 4.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057815 Fup NA 0.0288 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057815 Vd NA 1.568 L/kg 1compartment NA NA Rat Human -DTXSID2057815 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID2057815 TK.Half.Life NA 21.95 hours 1compartment NA NA Rat Human -DTXSID2057815 Css NA 2.699 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057815 Css NA 13.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057815 Css NA 1.681 mg/L PBTK NA 50% Rat Human -DTXSID2057815 Css NA 7.957 mg/L PBTK NA 95% Rat Human -DTXSID2057817 Clint NA 15.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057817 Fup NA 0.1383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057817 Vd NA 0.2497 L/kg 1compartment NA NA Human Human +DTXSID2057813 TK.Half.Life NA 0.6971 hours 1compartment NA NA Rat Human +DTXSID2057813 Css NA 0.01196 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057813 Css NA 0.09256 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057813 Css NA 0.009958 mg/L PBTK NA 50% Rat Human +DTXSID2057813 Css NA 0.05975 mg/L PBTK NA 95% Rat Human +DTXSID2057815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057815 Fup 0.063 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057815 Vd NA 2.563 L/kg 1compartment NA NA Human Human +DTXSID2057815 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2057815 TK.Half.Life NA 16.46 hours 1compartment NA NA Human Human +DTXSID2057815 Css NA 0.7756 mg/L 3compartmentss NA 50% Human Human +DTXSID2057815 Css NA 5.154 mg/L 3compartmentss NA 95% Human Human +DTXSID2057815 Css NA 0.5284 mg/L PBTK NA 50% Human Human +DTXSID2057815 Css NA 3.386 mg/L PBTK NA 95% Human Human +DTXSID2057815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057815 Fup 0.063 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057815 Vd NA 1.924 L/kg 1compartment NA NA Rat Human +DTXSID2057815 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2057815 TK.Half.Life NA 4.044 hours 1compartment NA NA Rat Human +DTXSID2057815 Css NA 0.1 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057815 Css NA 0.5447 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057815 Css NA 0.06697 mg/L PBTK NA 50% Rat Human +DTXSID2057815 Css NA 0.3524 mg/L PBTK NA 95% Rat Human +DTXSID2057817 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057817 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057817 Vd NA 0.4308 L/kg 1compartment NA NA Human Human DTXSID2057817 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057817 TK.Half.Life NA 0.6589 hours 1compartment NA NA Human Human -DTXSID2057817 Css NA 0.2922 mg/L 3compartmentss NA 50% Human Human -DTXSID2057817 Css NA 2.269 mg/L 3compartmentss NA 95% Human Human -DTXSID2057817 Css NA 0.18 mg/L PBTK NA 50% Human Human -DTXSID2057817 Css NA 1.362 mg/L PBTK NA 95% Human Human -DTXSID2057817 Clint NA 15.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057817 Fup NA 0.1383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057817 Vd NA 0.2505 L/kg 1compartment NA NA Rat Human +DTXSID2057817 TK.Half.Life NA 1.066 hours 1compartment NA NA Human Human +DTXSID2057817 Css NA 0.2206 mg/L 3compartmentss NA 50% Human Human +DTXSID2057817 Css NA 1.353 mg/L 3compartmentss NA 95% Human Human +DTXSID2057817 Css NA 0.1517 mg/L PBTK NA 50% Human Human +DTXSID2057817 Css NA 0.8817 mg/L PBTK NA 95% Human Human +DTXSID2057817 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057817 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057817 Vd NA 0.4212 L/kg 1compartment NA NA Rat Human DTXSID2057817 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057817 TK.Half.Life NA 0.3888 hours 1compartment NA NA Rat Human -DTXSID2057817 Css NA 0.165 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057817 Css NA 0.935 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057817 Css NA 0.09478 mg/L PBTK NA 50% Rat Human -DTXSID2057817 Css NA 0.5268 mg/L PBTK NA 95% Rat Human -DTXSID2057819 Clint NA 27.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057819 Fup NA 0.1469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID2057819 Vd NA 2.331 L/kg 1compartment NA NA Human Human +DTXSID2057817 TK.Half.Life NA 0.5904 hours 1compartment NA NA Rat Human +DTXSID2057817 Css NA 0.02599 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057817 Css NA 0.1219 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057817 Css NA 0.01761 mg/L PBTK NA 50% Rat Human +DTXSID2057817 Css NA 0.07403 mg/L PBTK NA 95% Rat Human +DTXSID2057819 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057819 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057819 Vd NA 3.207 L/kg 1compartment NA NA Human Human DTXSID2057819 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID2057819 TK.Half.Life NA 5.631 hours 1compartment NA NA Human Human -DTXSID2057819 Css NA 0.2264 mg/L 3compartmentss NA 50% Human Human -DTXSID2057819 Css NA 1.434 mg/L 3compartmentss NA 95% Human Human -DTXSID2057819 Css NA 0.1602 mg/L PBTK NA 50% Human Human -DTXSID2057819 Css NA 0.9504 mg/L PBTK NA 95% Human Human -DTXSID2057819 Clint NA 27.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057819 Fup NA 0.1469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID2057819 Vd NA 1.792 L/kg 1compartment NA NA Rat Human +DTXSID2057819 TK.Half.Life NA 6.123 hours 1compartment NA NA Human Human +DTXSID2057819 Css NA 0.133 mg/L 3compartmentss NA 50% Human Human +DTXSID2057819 Css NA 0.9609 mg/L 3compartmentss NA 95% Human Human +DTXSID2057819 Css NA 0.1161 mg/L PBTK NA 50% Human Human +DTXSID2057819 Css NA 0.7456 mg/L PBTK NA 95% Human Human +DTXSID2057819 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057819 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057819 Vd NA 2.837 L/kg 1compartment NA NA Rat Human DTXSID2057819 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID2057819 TK.Half.Life NA 1.74 hours 1compartment NA NA Rat Human -DTXSID2057819 Css NA 0.1236 mg/L 3compartmentss NA 50% Rat Human -DTXSID2057819 Css NA 0.6675 mg/L 3compartmentss NA 95% Rat Human -DTXSID2057819 Css NA 0.08358 mg/L PBTK NA 50% Rat Human -DTXSID2057819 Css NA 0.4247 mg/L PBTK NA 95% Rat Human +DTXSID2057819 TK.Half.Life NA 2.373 hours 1compartment NA NA Rat Human +DTXSID2057819 Css NA 0.01691 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057819 Css NA 0.09644 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057819 Css NA 0.0149 mg/L PBTK NA 50% Rat Human +DTXSID2057819 Css NA 0.07715 mg/L PBTK NA 95% Rat Human +DTXSID2057865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057865 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2057865 Vd NA 1.234 L/kg 1compartment NA NA Human Human +DTXSID2057865 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2057865 TK.Half.Life NA 1.185 hours 1compartment NA NA Human Human +DTXSID2057865 Css NA 0.0371 mg/L 3compartmentss NA 50% Human Human +DTXSID2057865 Css NA 0.3349 mg/L 3compartmentss NA 95% Human Human +DTXSID2057865 Css NA 0.03137 mg/L PBTK NA 50% Human Human +DTXSID2057865 Css NA 0.2458 mg/L PBTK NA 95% Human Human +DTXSID2057865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057865 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2057865 Vd NA 1.235 L/kg 1compartment NA NA Rat Human +DTXSID2057865 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2057865 TK.Half.Life NA 0.6123 hours 1compartment NA NA Rat Human +DTXSID2057865 Css NA 0.004495 mg/L 3compartmentss NA 50% Rat Human +DTXSID2057865 Css NA 0.03334 mg/L 3compartmentss NA 95% Rat Human +DTXSID2057865 Css NA 0.003919 mg/L PBTK NA 50% Rat Human +DTXSID2057865 Css NA 0.0237 mg/L PBTK NA 95% Rat Human +DTXSID2058251 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2058251 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID2058251 Vd NA 2.496 L/kg 1compartment NA NA Human Human +DTXSID2058251 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID2058251 TK.Half.Life NA 44.07 hours 1compartment NA NA Human Human +DTXSID2058251 Css NA 2.498 mg/L 3compartmentss NA 50% Human Human +DTXSID2058251 Css NA 18.76 mg/L 3compartmentss NA 95% Human Human +DTXSID2058251 Css NA 1.644 mg/L PBTK NA 50% Human Human +DTXSID2058251 Css NA 11.83 mg/L PBTK NA 95% Human Human +DTXSID2058251 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2058251 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID2058251 Vd NA 1.859 L/kg 1compartment NA NA Rat Human +DTXSID2058251 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID2058251 TK.Half.Life NA 10.82 hours 1compartment NA NA Rat Human +DTXSID2058251 Css NA 0.3258 mg/L 3compartmentss NA 50% Rat Human +DTXSID2058251 Css NA 2.084 mg/L 3compartmentss NA 95% Rat Human +DTXSID2058251 Css NA 0.2102 mg/L PBTK NA 50% Rat Human +DTXSID2058251 Css NA 1.298 mg/L PBTK NA 95% Rat Human +DTXSID2058621 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2058621 Fup 0.876 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2058621 Vd NA 0.8666 L/kg 1compartment NA NA Human Human +DTXSID2058621 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2058621 TK.Half.Life NA 6.472 hours 1compartment NA NA Human Human +DTXSID2058621 Css NA 0.8992 mg/L 3compartmentss NA 50% Human Human +DTXSID2058621 Css NA 5.366 mg/L 3compartmentss NA 95% Human Human +DTXSID2058621 Css NA 0.7582 mg/L PBTK NA 50% Human Human +DTXSID2058621 Css NA 3.502 mg/L PBTK NA 95% Human Human +DTXSID2058621 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2058621 Fup 0.876 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2058621 Vd NA 0.8625 L/kg 1compartment NA NA Rat Human +DTXSID2058621 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2058621 TK.Half.Life NA 2.176 hours 1compartment NA NA Rat Human +DTXSID2058621 Css NA 0.05358 mg/L 3compartmentss NA 50% Rat Human +DTXSID2058621 Css NA 0.3137 mg/L 3compartmentss NA 95% Rat Human +DTXSID2058621 Css NA 0.04536 mg/L PBTK NA 50% Rat Human +DTXSID2058621 Css NA 0.1963 mg/L PBTK NA 95% Rat Human +DTXSID2058629 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2058629 Fup 0.684 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2058629 Vd NA 0.7283 L/kg 1compartment NA NA Human Human +DTXSID2058629 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2058629 TK.Half.Life NA 6.89 hours 1compartment NA NA Human Human +DTXSID2058629 Css NA 0.9645 mg/L 3compartmentss NA 50% Human Human +DTXSID2058629 Css NA 6.356 mg/L 3compartmentss NA 95% Human Human +DTXSID2058629 Css NA 0.7734 mg/L PBTK NA 50% Human Human +DTXSID2058629 Css NA 4.062 mg/L PBTK NA 95% Human Human +DTXSID2058629 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2058629 Fup 0.684 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2058629 Vd NA 0.754 L/kg 1compartment NA NA Rat Human +DTXSID2058629 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2058629 TK.Half.Life NA 2.431 hours 1compartment NA NA Rat Human +DTXSID2058629 Css NA 0.02519 mg/L 3compartmentss NA 50% Rat Human +DTXSID2058629 Css NA 0.1882 mg/L 3compartmentss NA 95% Rat Human +DTXSID2058629 Css NA 0.01952 mg/L PBTK NA 50% Rat Human +DTXSID2058629 Css NA 0.1174 mg/L PBTK NA 95% Rat Human +DTXSID2059015 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2059015 Fup 0.0866 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2059015 Vd NA 1.343 L/kg 1compartment NA NA Human Human +DTXSID2059015 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2059015 TK.Half.Life NA 4.099 hours 1compartment NA NA Human Human +DTXSID2059015 Css NA 0.346 mg/L 3compartmentss NA 50% Human Human +DTXSID2059015 Css NA 2.621 mg/L 3compartmentss NA 95% Human Human +DTXSID2059015 Css NA 0.2262 mg/L PBTK NA 50% Human Human +DTXSID2059015 Css NA 1.629 mg/L PBTK NA 95% Human Human +DTXSID2059015 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2059015 Fup 0.0866 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2059015 Vd NA 1.029 L/kg 1compartment NA NA Rat Human +DTXSID2059015 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2059015 TK.Half.Life NA 1.653 hours 1compartment NA NA Rat Human +DTXSID2059015 Css NA 0.04514 mg/L 3compartmentss NA 50% Rat Human +DTXSID2059015 Css NA 0.271 mg/L 3compartmentss NA 95% Rat Human +DTXSID2059015 Css NA 0.02884 mg/L PBTK NA 50% Rat Human +DTXSID2059015 Css NA 0.1645 mg/L PBTK NA 95% Rat Human +DTXSID2059192 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2059192 Fup 0.0477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2059192 Vd NA 1.001 L/kg 1compartment NA NA Human Human +DTXSID2059192 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2059192 TK.Half.Life NA 12.76 hours 1compartment NA NA Human Human +DTXSID2059192 Css NA 2.038 mg/L 3compartmentss NA 50% Human Human +DTXSID2059192 Css NA 14.51 mg/L 3compartmentss NA 95% Human Human +DTXSID2059192 Css NA 1.268 mg/L PBTK NA 50% Human Human +DTXSID2059192 Css NA 8.808 mg/L PBTK NA 95% Human Human +DTXSID2059192 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2059192 Fup 0.0477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2059192 Vd NA 0.763 L/kg 1compartment NA NA Rat Human +DTXSID2059192 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2059192 TK.Half.Life NA 5.523 hours 1compartment NA NA Rat Human +DTXSID2059192 Css NA 0.2502 mg/L 3compartmentss NA 50% Rat Human +DTXSID2059192 Css NA 1.308 mg/L 3compartmentss NA 95% Rat Human +DTXSID2059192 Css NA 0.1515 mg/L PBTK NA 50% Rat Human +DTXSID2059192 Css NA 0.7587 mg/L PBTK NA 95% Rat Human +DTXSID2060173 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2060173 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2060173 Vd NA 1.714 L/kg 1compartment NA NA Human Human +DTXSID2060173 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2060173 TK.Half.Life NA 2.912 hours 1compartment NA NA Human Human +DTXSID2060173 Css NA 0.1123 mg/L 3compartmentss NA 50% Human Human +DTXSID2060173 Css NA 0.7908 mg/L 3compartmentss NA 95% Human Human +DTXSID2060173 Css NA 0.08341 mg/L PBTK NA 50% Human Human +DTXSID2060173 Css NA 0.5509 mg/L PBTK NA 95% Human Human +DTXSID2060173 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2060173 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2060173 Vd NA 1.385 L/kg 1compartment NA NA Rat Human +DTXSID2060173 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2060173 TK.Half.Life NA 1.146 hours 1compartment NA NA Rat Human +DTXSID2060173 Css NA 0.01433 mg/L 3compartmentss NA 50% Rat Human +DTXSID2060173 Css NA 0.07527 mg/L 3compartmentss NA 95% Rat Human +DTXSID2060173 Css NA 0.01058 mg/L PBTK NA 50% Rat Human +DTXSID2060173 Css NA 0.05096 mg/L PBTK NA 95% Rat Human +DTXSID2060416 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2060416 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2060416 Vd NA 2.302 L/kg 1compartment NA NA Human Human +DTXSID2060416 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2060416 TK.Half.Life NA 5.059 hours 1compartment NA NA Human Human +DTXSID2060416 Css NA 0.1709 mg/L 3compartmentss NA 50% Human Human +DTXSID2060416 Css NA 1.136 mg/L 3compartmentss NA 95% Human Human +DTXSID2060416 Css NA 0.1247 mg/L PBTK NA 50% Human Human +DTXSID2060416 Css NA 0.7863 mg/L PBTK NA 95% Human Human +DTXSID2060416 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2060416 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2060416 Vd NA 1.766 L/kg 1compartment NA NA Rat Human +DTXSID2060416 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2060416 TK.Half.Life NA 1.553 hours 1compartment NA NA Rat Human +DTXSID2060416 Css NA 0.02159 mg/L 3compartmentss NA 50% Rat Human +DTXSID2060416 Css NA 0.1128 mg/L 3compartmentss NA 95% Rat Human +DTXSID2060416 Css NA 0.01574 mg/L PBTK NA 50% Rat Human +DTXSID2060416 Css NA 0.07919 mg/L PBTK NA 95% Rat Human +DTXSID2060549 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2060549 Fup 0.0657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2060549 Vd NA 1.21 L/kg 1compartment NA NA Human Human +DTXSID2060549 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID2060549 TK.Half.Life NA 12.06 hours 1compartment NA NA Human Human +DTXSID2060549 Css NA 1.386 mg/L 3compartmentss NA 50% Human Human +DTXSID2060549 Css NA 8.294 mg/L 3compartmentss NA 95% Human Human +DTXSID2060549 Css NA 0.8908 mg/L PBTK NA 50% Human Human +DTXSID2060549 Css NA 5.178 mg/L PBTK NA 95% Human Human +DTXSID2060549 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2060549 Fup 0.0657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2060549 Vd NA 0.9235 L/kg 1compartment NA NA Rat Human +DTXSID2060549 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2060549 TK.Half.Life NA 4.983 hours 1compartment NA NA Rat Human +DTXSID2060549 Css NA 0.1719 mg/L 3compartmentss NA 50% Rat Human +DTXSID2060549 Css NA 0.7485 mg/L 3compartmentss NA 95% Rat Human +DTXSID2060549 Css NA 0.1077 mg/L PBTK NA 50% Rat Human +DTXSID2060549 Css NA 0.4427 mg/L PBTK NA 95% Rat Human +DTXSID2060753 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2060753 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2060753 Vd NA 53.26 L/kg 1compartment NA NA Human Human +DTXSID2060753 Days.Css NA 398 Days PBTK NA NA Human Human +DTXSID2060753 TK.Half.Life NA 1576 hours 1compartment NA NA Human Human +DTXSID2060753 Css NA 0.22 mg/L 3compartmentss NA 50% Human Human +DTXSID2060753 Css NA 1.557 mg/L 3compartmentss NA 95% Human Human +DTXSID2060753 Css NA 1.305 mg/L PBTK NA 50% Human Human +DTXSID2060753 Css NA 8.377 mg/L PBTK NA 95% Human Human +DTXSID2060753 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2060753 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2060753 Vd NA 45.02 L/kg 1compartment NA NA Rat Human +DTXSID2060753 Days.Css NA 247 Days PBTK NA NA Rat Human +DTXSID2060753 TK.Half.Life NA 232.2 hours 1compartment NA NA Rat Human +DTXSID2060753 Css NA 0.002193 mg/L 3compartmentss NA 50% Rat Human +DTXSID2060753 Css NA 0.01302 mg/L 3compartmentss NA 95% Rat Human +DTXSID2060753 Css NA 0.01382 mg/L PBTK NA 50% Rat Human +DTXSID2060753 Css NA 0.08243 mg/L PBTK NA 95% Rat Human +DTXSID2064733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2064733 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID2064733 Vd NA 1.208 L/kg 1compartment NA NA Human Human +DTXSID2064733 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID2064733 TK.Half.Life NA 1.054 hours 1compartment NA NA Human Human +DTXSID2064733 Css NA 0.03165 mg/L 3compartmentss NA 50% Human Human +DTXSID2064733 Css NA 0.3394 mg/L 3compartmentss NA 95% Human Human +DTXSID2064733 Css NA 0.02708 mg/L PBTK NA 50% Human Human +DTXSID2064733 Css NA 0.2378 mg/L PBTK NA 95% Human Human +DTXSID2064733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2064733 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID2064733 Vd NA 1.09 L/kg 1compartment NA NA Rat Human +DTXSID2064733 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID2064733 TK.Half.Life NA 0.4643 hours 1compartment NA NA Rat Human +DTXSID2064733 Css NA 0.003791 mg/L 3compartmentss NA 50% Rat Human +DTXSID2064733 Css NA 0.03722 mg/L 3compartmentss NA 95% Rat Human +DTXSID2064733 Css NA 0.003288 mg/L PBTK NA 50% Rat Human +DTXSID2064733 Css NA 0.02506 mg/L PBTK NA 95% Rat Human +DTXSID20648089 Clint 1.985 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20648089 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20648089 Vd NA 0.6679 L/kg 1compartment NA NA Human Human +DTXSID20648089 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20648089 TK.Half.Life NA 2.956 hours 1compartment NA NA Human Human +DTXSID20648089 Css NA 0.3914 mg/L 3compartmentss NA 50% Human Human +DTXSID20648089 Css NA 2.181 mg/L 3compartmentss NA 95% Human Human +DTXSID20648089 Css NA 0.2908 mg/L PBTK NA 50% Human Human +DTXSID20648089 Css NA 1.408 mg/L PBTK NA 95% Human Human +DTXSID20648089 Clint 1.985 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20648089 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20648089 Vd NA 0.6416 L/kg 1compartment NA NA Rat Human +DTXSID20648089 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20648089 TK.Half.Life NA 1.508 hours 1compartment NA NA Rat Human +DTXSID20648089 Css NA 0.01504 mg/L 3compartmentss NA 50% Rat Human +DTXSID20648089 Css NA 0.1015 mg/L 3compartmentss NA 95% Rat Human +DTXSID20648089 Css NA 0.01118 mg/L PBTK NA 50% Rat Human +DTXSID20648089 Css NA 0.06598 mg/L PBTK NA 95% Rat Human +DTXSID20859299 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20859299 Fup 0.009 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human +DTXSID20859299 Vd NA 0.2182 L/kg 1compartment NA NA Human Human +DTXSID20859299 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID20859299 TK.Half.Life NA 13.49 hours 1compartment NA NA Human Human +DTXSID20859299 Css NA 11.27 mg/L 3compartmentss NA 50% Human Human +DTXSID20859299 Css NA 98.16 mg/L 3compartmentss NA 95% Human Human +DTXSID20859299 Css NA 6.578 mg/L PBTK NA 50% Human Human +DTXSID20859299 Css NA 57.33 mg/L PBTK NA 95% Human Human +DTXSID20859299 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20859299 Fup 0.009 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human +DTXSID20859299 Vd NA 0.1968 L/kg 1compartment NA NA Rat Human +DTXSID20859299 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20859299 TK.Half.Life NA 7.781 hours 1compartment NA NA Rat Human +DTXSID20859299 Css NA 1.422 mg/L 3compartmentss NA 50% Rat Human +DTXSID20859299 Css NA 9.466 mg/L 3compartmentss NA 95% Rat Human +DTXSID20859299 Css NA 0.8008 mg/L PBTK NA 50% Rat Human +DTXSID20859299 Css NA 5.295 mg/L PBTK NA 95% Rat Human +DTXSID20861271 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20861271 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20861271 Vd NA 3.155 L/kg 1compartment NA NA Human Human +DTXSID20861271 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID20861271 TK.Half.Life NA 40.87 hours 1compartment NA NA Human Human +DTXSID20861271 Css NA 1.437 mg/L 3compartmentss NA 50% Human Human +DTXSID20861271 Css NA 9.409 mg/L 3compartmentss NA 95% Human Human +DTXSID20861271 Css NA 1.011 mg/L PBTK NA 50% Human Human +DTXSID20861271 Css NA 6.352 mg/L PBTK NA 95% Human Human +DTXSID20861271 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20861271 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20861271 Vd NA 2.375 L/kg 1compartment NA NA Rat Human +DTXSID20861271 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID20861271 TK.Half.Life NA 5.71 hours 1compartment NA NA Rat Human +DTXSID20861271 Css NA 0.1842 mg/L 3compartmentss NA 50% Rat Human +DTXSID20861271 Css NA 1.018 mg/L 3compartmentss NA 95% Rat Human +DTXSID20861271 Css NA 0.1291 mg/L PBTK NA 50% Rat Human +DTXSID20861271 Css NA 0.6992 mg/L PBTK NA 95% Rat Human +DTXSID20862021 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20862021 Fup 0.0329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20862021 Vd NA 2.744 L/kg 1compartment NA NA Human Human +DTXSID20862021 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID20862021 TK.Half.Life NA 31.24 hours 1compartment NA NA Human Human +DTXSID20862021 Css NA 1.47 mg/L 3compartmentss NA 50% Human Human +DTXSID20862021 Css NA 9.783 mg/L 3compartmentss NA 95% Human Human +DTXSID20862021 Css NA 0.996 mg/L PBTK NA 50% Human Human +DTXSID20862021 Css NA 6.371 mg/L PBTK NA 95% Human Human +DTXSID20862021 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20862021 Fup 0.0329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20862021 Vd NA 2.054 L/kg 1compartment NA NA Rat Human +DTXSID20862021 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID20862021 TK.Half.Life NA 6.533 hours 1compartment NA NA Rat Human +DTXSID20862021 Css NA 0.1897 mg/L 3compartmentss NA 50% Rat Human +DTXSID20862021 Css NA 1.074 mg/L 3compartmentss NA 95% Rat Human +DTXSID20862021 Css NA 0.1265 mg/L PBTK NA 50% Rat Human +DTXSID20862021 Css NA 0.6887 mg/L PBTK NA 95% Rat Human +DTXSID20862324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20862324 Fup 0.0191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20862324 Vd NA 3.11 L/kg 1compartment NA NA Human Human +DTXSID20862324 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID20862324 TK.Half.Life NA 87.28 hours 1compartment NA NA Human Human +DTXSID20862324 Css NA 1.84 mg/L 3compartmentss NA 50% Human Human +DTXSID20862324 Css NA 12.1 mg/L 3compartmentss NA 95% Human Human +DTXSID20862324 Css NA 1.275 mg/L PBTK NA 50% Human Human +DTXSID20862324 Css NA 8.307 mg/L PBTK NA 95% Human Human +DTXSID20862324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20862324 Fup 0.0191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20862324 Vd NA 2.329 L/kg 1compartment NA NA Rat Human +DTXSID20862324 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID20862324 TK.Half.Life NA 11.92 hours 1compartment NA NA Rat Human +DTXSID20862324 Css NA 0.02001 mg/L 3compartmentss NA 50% Rat Human +DTXSID20862324 Css NA 0.1219 mg/L 3compartmentss NA 95% Rat Human +DTXSID20862324 Css NA 0.01326 mg/L PBTK NA 50% Rat Human +DTXSID20862324 Css NA 0.0802 mg/L PBTK NA 95% Rat Human +DTXSID20862889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20862889 Fup 0.309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20862889 Vd NA 0.8317 L/kg 1compartment NA NA Human Human +DTXSID20862889 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20862889 TK.Half.Life NA 1.067 hours 1compartment NA NA Human Human +DTXSID20862889 Css NA 0.06515 mg/L 3compartmentss NA 50% Human Human +DTXSID20862889 Css NA 0.4942 mg/L 3compartmentss NA 95% Human Human +DTXSID20862889 Css NA 0.04766 mg/L PBTK NA 50% Human Human +DTXSID20862889 Css NA 0.3334 mg/L PBTK NA 95% Human Human +DTXSID20862889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20862889 Fup 0.309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20862889 Vd NA 0.742 L/kg 1compartment NA NA Rat Human +DTXSID20862889 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20862889 TK.Half.Life NA 0.498 hours 1compartment NA NA Rat Human +DTXSID20862889 Css NA 0.008191 mg/L 3compartmentss NA 50% Rat Human +DTXSID20862889 Css NA 0.04675 mg/L 3compartmentss NA 95% Rat Human +DTXSID20862889 Css NA 0.005974 mg/L PBTK NA 50% Rat Human +DTXSID20862889 Css NA 0.03115 mg/L PBTK NA 95% Rat Human +DTXSID20863674 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20863674 Fup 0.0429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20863674 Vd NA 0.31 L/kg 1compartment NA NA Human Human +DTXSID20863674 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20863674 TK.Half.Life NA 4.354 hours 1compartment NA NA Human Human +DTXSID20863674 Css NA 2.285 mg/L 3compartmentss NA 50% Human Human +DTXSID20863674 Css NA 17.72 mg/L 3compartmentss NA 95% Human Human +DTXSID20863674 Css NA 1.402 mg/L PBTK NA 50% Human Human +DTXSID20863674 Css NA 10.55 mg/L PBTK NA 95% Human Human +DTXSID20863674 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20863674 Fup 0.0429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20863674 Vd NA 0.3021 L/kg 1compartment NA NA Rat Human +DTXSID20863674 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20863674 TK.Half.Life NA 2.661 hours 1compartment NA NA Rat Human +DTXSID20863674 Css NA 0.2864 mg/L 3compartmentss NA 50% Rat Human +DTXSID20863674 Css NA 1.68 mg/L 3compartmentss NA 95% Rat Human +DTXSID20863674 Css NA 0.1702 mg/L PBTK NA 50% Rat Human +DTXSID20863674 Css NA 0.9637 mg/L PBTK NA 95% Rat Human +DTXSID20864287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20864287 Fup 0.0443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20864287 Vd NA 3.111 L/kg 1compartment NA NA Human Human +DTXSID20864287 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID20864287 TK.Half.Life NA 74.36 hours 1compartment NA NA Human Human +DTXSID20864287 Css NA 2.818 mg/L 3compartmentss NA 50% Human Human +DTXSID20864287 Css NA 18.09 mg/L 3compartmentss NA 95% Human Human +DTXSID20864287 Css NA 1.951 mg/L PBTK NA 50% Human Human +DTXSID20864287 Css NA 12.2 mg/L PBTK NA 95% Human Human +DTXSID20864287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20864287 Fup 0.0443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20864287 Vd NA 2.331 L/kg 1compartment NA NA Rat Human +DTXSID20864287 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID20864287 TK.Half.Life NA 10.24 hours 1compartment NA NA Rat Human +DTXSID20864287 Css NA 0.3644 mg/L 3compartmentss NA 50% Rat Human +DTXSID20864287 Css NA 2.141 mg/L 3compartmentss NA 95% Rat Human +DTXSID20864287 Css NA 0.2511 mg/L PBTK NA 50% Rat Human +DTXSID20864287 Css NA 1.402 mg/L PBTK NA 95% Rat Human +DTXSID20868982 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20868982 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20868982 Vd NA 0.9756 L/kg 1compartment NA NA Human Human +DTXSID20868982 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID20868982 TK.Half.Life NA 11.31 hours 1compartment NA NA Human Human +DTXSID20868982 Css NA 0.6742 mg/L 3compartmentss NA 50% Human Human +DTXSID20868982 Css NA 4.749 mg/L 3compartmentss NA 95% Human Human +DTXSID20868982 Css NA 0.5685 mg/L PBTK NA 50% Human Human +DTXSID20868982 Css NA 3.09 mg/L PBTK NA 95% Human Human +DTXSID20868982 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20868982 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20868982 Vd NA 0.9131 L/kg 1compartment NA NA Rat Human +DTXSID20868982 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20868982 TK.Half.Life NA 3.504 hours 1compartment NA NA Rat Human +DTXSID20868982 Css NA 0.00352 mg/L 3compartmentss NA 50% Rat Human +DTXSID20868982 Css NA 0.02653 mg/L 3compartmentss NA 95% Rat Human +DTXSID20868982 Css NA 0.00285 mg/L PBTK NA 50% Rat Human +DTXSID20868982 Css NA 0.01617 mg/L PBTK NA 95% Rat Human +DTXSID20869010 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20869010 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20869010 Vd NA 0.7578 L/kg 1compartment NA NA Human Human +DTXSID20869010 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20869010 TK.Half.Life NA 7.599 hours 1compartment NA NA Human Human +DTXSID20869010 Css NA 0.982 mg/L 3compartmentss NA 50% Human Human +DTXSID20869010 Css NA 6.704 mg/L 3compartmentss NA 95% Human Human +DTXSID20869010 Css NA 0.7998 mg/L PBTK NA 50% Human Human +DTXSID20869010 Css NA 4.227 mg/L PBTK NA 95% Human Human +DTXSID20869010 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20869010 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20869010 Vd NA 0.7574 L/kg 1compartment NA NA Rat Human +DTXSID20869010 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20869010 TK.Half.Life NA 2.574 hours 1compartment NA NA Rat Human +DTXSID20869010 Css NA 0.02513 mg/L 3compartmentss NA 50% Rat Human +DTXSID20869010 Css NA 0.202 mg/L 3compartmentss NA 95% Rat Human +DTXSID20869010 Css NA 0.02001 mg/L PBTK NA 50% Rat Human +DTXSID20869010 Css NA 0.1289 mg/L PBTK NA 95% Rat Human +DTXSID20869373 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20869373 Fup 0.46 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20869373 Vd NA 2.037 L/kg 1compartment NA NA Human Human +DTXSID20869373 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20869373 TK.Half.Life NA 3.197 hours 1compartment NA NA Human Human +DTXSID20869373 Css NA 0.08214 mg/L 3compartmentss NA 50% Human Human +DTXSID20869373 Css NA 0.6959 mg/L 3compartmentss NA 95% Human Human +DTXSID20869373 Css NA 0.08526 mg/L PBTK NA 50% Human Human +DTXSID20869373 Css NA 0.5592 mg/L PBTK NA 95% Human Human +DTXSID20869373 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20869373 Fup 0.46 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20869373 Vd NA 2.002 L/kg 1compartment NA NA Rat Human +DTXSID20869373 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20869373 TK.Half.Life NA 1.794 hours 1compartment NA NA Rat Human +DTXSID20869373 Css NA 0.003424 mg/L 3compartmentss NA 50% Rat Human +DTXSID20869373 Css NA 0.03547 mg/L 3compartmentss NA 95% Rat Human +DTXSID20869373 Css NA 0.003722 mg/L PBTK NA 50% Rat Human +DTXSID20869373 Css NA 0.02785 mg/L PBTK NA 95% Rat Human +DTXSID20869939 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20869939 Fup 0.94 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20869939 Vd NA 0.8274 L/kg 1compartment NA NA Human Human +DTXSID20869939 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20869939 TK.Half.Life NA 5.705 hours 1compartment NA NA Human Human +DTXSID20869939 Css NA 0.4847 mg/L 3compartmentss NA 50% Human Human +DTXSID20869939 Css NA 2.919 mg/L 3compartmentss NA 95% Human Human +DTXSID20869939 Css NA 0.4112 mg/L PBTK NA 50% Human Human +DTXSID20869939 Css NA 1.908 mg/L PBTK NA 95% Human Human +DTXSID20869939 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20869939 Fup 0.94 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20869939 Vd NA 0.8526 L/kg 1compartment NA NA Rat Human +DTXSID20869939 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20869939 TK.Half.Life NA 2.001 hours 1compartment NA NA Rat Human +DTXSID20869939 Css NA 0.002451 mg/L 3compartmentss NA 50% Rat Human +DTXSID20869939 Css NA 0.01575 mg/L 3compartmentss NA 95% Rat Human +DTXSID20869939 Css NA 0.002038 mg/L PBTK NA 50% Rat Human +DTXSID20869939 Css NA 0.01017 mg/L PBTK NA 95% Rat Human +DTXSID20873213 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20873213 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20873213 Vd NA 4.222 L/kg 1compartment NA NA Human Human +DTXSID20873213 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20873213 TK.Half.Life NA 6.671 hours 1compartment NA NA Human Human +DTXSID20873213 Css NA 0.09229 mg/L 3compartmentss NA 50% Human Human +DTXSID20873213 Css NA 0.8344 mg/L 3compartmentss NA 95% Human Human +DTXSID20873213 Css NA 0.1117 mg/L PBTK NA 50% Human Human +DTXSID20873213 Css NA 0.7395 mg/L PBTK NA 95% Human Human +DTXSID20873213 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20873213 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20873213 Vd NA 4.029 L/kg 1compartment NA NA Rat Human +DTXSID20873213 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20873213 TK.Half.Life NA 2.858 hours 1compartment NA NA Rat Human +DTXSID20873213 Css NA 0.01019 mg/L 3compartmentss NA 50% Rat Human +DTXSID20873213 Css NA 0.08342 mg/L 3compartmentss NA 95% Rat Human +DTXSID20873213 Css NA 0.01296 mg/L PBTK NA 50% Rat Human +DTXSID20873213 Css NA 0.06724 mg/L PBTK NA 95% Rat Human +DTXSID20873334 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20873334 Fup 0.043 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20873334 Vd NA 2.672 L/kg 1compartment NA NA Human Human +DTXSID20873334 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID20873334 TK.Half.Life NA 24.27 hours 1compartment NA NA Human Human +DTXSID20873334 Css NA 0.9976 mg/L 3compartmentss NA 50% Human Human +DTXSID20873334 Css NA 6.726 mg/L 3compartmentss NA 95% Human Human +DTXSID20873334 Css NA 0.6774 mg/L PBTK NA 50% Human Human +DTXSID20873334 Css NA 4.432 mg/L PBTK NA 95% Human Human +DTXSID20873334 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20873334 Fup 0.043 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20873334 Vd NA 2.001 L/kg 1compartment NA NA Rat Human +DTXSID20873334 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID20873334 TK.Half.Life NA 5.419 hours 1compartment NA NA Rat Human +DTXSID20873334 Css NA 0.04998 mg/L 3compartmentss NA 50% Rat Human +DTXSID20873334 Css NA 0.3423 mg/L 3compartmentss NA 95% Rat Human +DTXSID20873334 Css NA 0.03299 mg/L PBTK NA 50% Rat Human +DTXSID20873334 Css NA 0.2128 mg/L PBTK NA 95% Rat Human +DTXSID20879477 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20879477 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20879477 Vd NA 0.8126 L/kg 1compartment NA NA Human Human +DTXSID20879477 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20879477 TK.Half.Life NA 0.9107 hours 1compartment NA NA Human Human +DTXSID20879477 Css NA 0.04897 mg/L 3compartmentss NA 50% Human Human +DTXSID20879477 Css NA 0.3995 mg/L 3compartmentss NA 95% Human Human +DTXSID20879477 Css NA 0.03689 mg/L PBTK NA 50% Human Human +DTXSID20879477 Css NA 0.272 mg/L PBTK NA 95% Human Human +DTXSID20879477 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20879477 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20879477 Vd NA 0.7473 L/kg 1compartment NA NA Rat Human +DTXSID20879477 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20879477 TK.Half.Life NA 0.4289 hours 1compartment NA NA Rat Human +DTXSID20879477 Css NA 0.005938 mg/L 3compartmentss NA 50% Rat Human +DTXSID20879477 Css NA 0.0381 mg/L 3compartmentss NA 95% Rat Human +DTXSID20879477 Css NA 0.004526 mg/L PBTK NA 50% Rat Human +DTXSID20879477 Css NA 0.02531 mg/L PBTK NA 95% Rat Human +DTXSID20880629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880629 Fup 0.0356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880629 Vd NA 2.55 L/kg 1compartment NA NA Human Human +DTXSID20880629 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID20880629 TK.Half.Life NA 23.38 hours 1compartment NA NA Human Human +DTXSID20880629 Css NA 1.195 mg/L 3compartmentss NA 50% Human Human +DTXSID20880629 Css NA 7.969 mg/L 3compartmentss NA 95% Human Human +DTXSID20880629 Css NA 0.7988 mg/L PBTK NA 50% Human Human +DTXSID20880629 Css NA 5.124 mg/L PBTK NA 95% Human Human +DTXSID20880629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880629 Fup 0.0356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880629 Vd NA 1.908 L/kg 1compartment NA NA Rat Human +DTXSID20880629 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID20880629 TK.Half.Life NA 5.668 hours 1compartment NA NA Rat Human +DTXSID20880629 Css NA 0.1538 mg/L 3compartmentss NA 50% Rat Human +DTXSID20880629 Css NA 0.835 mg/L 3compartmentss NA 95% Rat Human +DTXSID20880629 Css NA 0.1014 mg/L PBTK NA 50% Rat Human +DTXSID20880629 Css NA 0.5343 mg/L PBTK NA 95% Rat Human +DTXSID20880684 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880684 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880684 Vd NA 2.623 L/kg 1compartment NA NA Human Human +DTXSID20880684 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20880684 TK.Half.Life NA 8.724 hours 1compartment NA NA Human Human +DTXSID20880684 Css NA 0.2865 mg/L 3compartmentss NA 50% Human Human +DTXSID20880684 Css NA 1.645 mg/L 3compartmentss NA 95% Human Human +DTXSID20880684 Css NA 0.2378 mg/L PBTK NA 50% Human Human +DTXSID20880684 Css NA 1.24 mg/L PBTK NA 95% Human Human +DTXSID20880684 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880684 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880684 Vd NA 2.16 L/kg 1compartment NA NA Rat Human +DTXSID20880684 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20880684 TK.Half.Life NA 2.817 hours 1compartment NA NA Rat Human +DTXSID20880684 Css NA 0.03349 mg/L 3compartmentss NA 50% Rat Human +DTXSID20880684 Css NA 0.1374 mg/L 3compartmentss NA 95% Rat Human +DTXSID20880684 Css NA 0.02794 mg/L PBTK NA 50% Rat Human +DTXSID20880684 Css NA 0.1012 mg/L PBTK NA 95% Rat Human +DTXSID20880740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880740 Fup 0.0307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880740 Vd NA 3.177 L/kg 1compartment NA NA Human Human +DTXSID20880740 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID20880740 TK.Half.Life NA 95.58 hours 1compartment NA NA Human Human +DTXSID20880740 Css NA 1.846 mg/L 3compartmentss NA 50% Human Human +DTXSID20880740 Css NA 11.56 mg/L 3compartmentss NA 95% Human Human +DTXSID20880740 Css NA 1.289 mg/L PBTK NA 50% Human Human +DTXSID20880740 Css NA 7.95 mg/L PBTK NA 95% Human Human +DTXSID20880740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880740 Fup 0.0307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880740 Vd NA 2.381 L/kg 1compartment NA NA Rat Human +DTXSID20880740 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID20880740 TK.Half.Life NA 12.67 hours 1compartment NA NA Rat Human +DTXSID20880740 Css NA 0.02022 mg/L 3compartmentss NA 50% Rat Human +DTXSID20880740 Css NA 0.1188 mg/L 3compartmentss NA 95% Rat Human +DTXSID20880740 Css NA 0.01358 mg/L PBTK NA 50% Rat Human +DTXSID20880740 Css NA 0.0798 mg/L PBTK NA 95% Rat Human +DTXSID20880780 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880780 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880780 Vd NA 3.219 L/kg 1compartment NA NA Human Human +DTXSID20880780 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20880780 TK.Half.Life NA 2.238 hours 1compartment NA NA Human Human +DTXSID20880780 Css NA 0.02068 mg/L 3compartmentss NA 50% Human Human +DTXSID20880780 Css NA 0.2234 mg/L 3compartmentss NA 95% Human Human +DTXSID20880780 Css NA 0.02693 mg/L PBTK NA 50% Human Human +DTXSID20880780 Css NA 0.2131 mg/L PBTK NA 95% Human Human +DTXSID20880780 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880780 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880780 Vd NA 3.198 L/kg 1compartment NA NA Rat Human +DTXSID20880780 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20880780 TK.Half.Life NA 1.196 hours 1compartment NA NA Rat Human +DTXSID20880780 Css NA 0.002468 mg/L 3compartmentss NA 50% Rat Human +DTXSID20880780 Css NA 0.02217 mg/L 3compartmentss NA 95% Rat Human +DTXSID20880780 Css NA 0.003401 mg/L PBTK NA 50% Rat Human +DTXSID20880780 Css NA 0.0206 mg/L PBTK NA 95% Rat Human +DTXSID20880826 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880826 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880826 Vd NA 0.2486 L/kg 1compartment NA NA Human Human +DTXSID20880826 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20880826 TK.Half.Life NA 2.002 hours 1compartment NA NA Human Human +DTXSID20880826 Css NA 1.321 mg/L 3compartmentss NA 50% Human Human +DTXSID20880826 Css NA 12.93 mg/L 3compartmentss NA 95% Human Human +DTXSID20880826 Css NA 0.7871 mg/L PBTK NA 50% Human Human +DTXSID20880826 Css NA 7.546 mg/L PBTK NA 95% Human Human +DTXSID20880826 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880826 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880826 Vd NA 0.2368 L/kg 1compartment NA NA Rat Human +DTXSID20880826 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20880826 TK.Half.Life NA 1.244 hours 1compartment NA NA Rat Human +DTXSID20880826 Css NA 0.1732 mg/L 3compartmentss NA 50% Rat Human +DTXSID20880826 Css NA 1.408 mg/L 3compartmentss NA 95% Rat Human +DTXSID20880826 Css NA 0.1003 mg/L PBTK NA 50% Rat Human +DTXSID20880826 Css NA 0.7933 mg/L PBTK NA 95% Rat Human +DTXSID20880902 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880902 Fup 0.0317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880902 Vd NA 3.06 L/kg 1compartment NA NA Human Human +DTXSID20880902 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID20880902 TK.Half.Life NA 62.05 hours 1compartment NA NA Human Human +DTXSID20880902 Css NA 2.436 mg/L 3compartmentss NA 50% Human Human +DTXSID20880902 Css NA 15.98 mg/L 3compartmentss NA 95% Human Human +DTXSID20880902 Css NA 1.688 mg/L PBTK NA 50% Human Human +DTXSID20880902 Css NA 10.67 mg/L PBTK NA 95% Human Human +DTXSID20880902 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880902 Fup 0.0317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880902 Vd NA 2.292 L/kg 1compartment NA NA Rat Human +DTXSID20880902 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID20880902 TK.Half.Life NA 9.215 hours 1compartment NA NA Rat Human +DTXSID20880902 Css NA 0.3161 mg/L 3compartmentss NA 50% Rat Human +DTXSID20880902 Css NA 1.767 mg/L 3compartmentss NA 95% Rat Human +DTXSID20880902 Css NA 0.2166 mg/L PBTK NA 50% Rat Human +DTXSID20880902 Css NA 1.17 mg/L PBTK NA 95% Rat Human +DTXSID20880907 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880907 Fup 0.0221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880907 Vd NA 1.716 L/kg 1compartment NA NA Human Human +DTXSID20880907 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID20880907 TK.Half.Life NA 15.27 hours 1compartment NA NA Human Human +DTXSID20880907 Css NA 1.342 mg/L 3compartmentss NA 50% Human Human +DTXSID20880907 Css NA 11.77 mg/L 3compartmentss NA 95% Human Human +DTXSID20880907 Css NA 0.8555 mg/L PBTK NA 50% Human Human +DTXSID20880907 Css NA 7.331 mg/L PBTK NA 95% Human Human +DTXSID20880907 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880907 Fup 0.0221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880907 Vd NA 1.274 L/kg 1compartment NA NA Rat Human +DTXSID20880907 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20880907 TK.Half.Life NA 5.479 hours 1compartment NA NA Rat Human +DTXSID20880907 Css NA 0.1732 mg/L 3compartmentss NA 50% Rat Human +DTXSID20880907 Css NA 1.18 mg/L 3compartmentss NA 95% Rat Human +DTXSID20880907 Css NA 0.1069 mg/L PBTK NA 50% Rat Human +DTXSID20880907 Css NA 0.7036 mg/L PBTK NA 95% Rat Human +DTXSID20880922 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880922 Fup 0.227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20880922 Vd NA 2.142 L/kg 1compartment NA NA Human Human +DTXSID20880922 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20880922 TK.Half.Life NA 4.255 hours 1compartment NA NA Human Human +DTXSID20880922 Css NA 0.1455 mg/L 3compartmentss NA 50% Human Human +DTXSID20880922 Css NA 0.9486 mg/L 3compartmentss NA 95% Human Human +DTXSID20880922 Css NA 0.1078 mg/L PBTK NA 50% Human Human +DTXSID20880922 Css NA 0.6649 mg/L PBTK NA 95% Human Human +DTXSID20880922 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880922 Fup 0.227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20880922 Vd NA 1.652 L/kg 1compartment NA NA Rat Human +DTXSID20880922 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20880922 TK.Half.Life NA 1.392 hours 1compartment NA NA Rat Human +DTXSID20880922 Css NA 0.01862 mg/L 3compartmentss NA 50% Rat Human +DTXSID20880922 Css NA 0.0949 mg/L 3compartmentss NA 95% Rat Human +DTXSID20880922 Css NA 0.0136 mg/L PBTK NA 50% Rat Human +DTXSID20880922 Css NA 0.06613 mg/L PBTK NA 95% Rat Human +DTXSID20881237 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20881237 Fup 0.0237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20881237 Vd NA 3.126 L/kg 1compartment NA NA Human Human +DTXSID20881237 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID20881237 TK.Half.Life NA 93.44 hours 1compartment NA NA Human Human +DTXSID20881237 Css NA 3.408 mg/L 3compartmentss NA 50% Human Human +DTXSID20881237 Css NA 20.73 mg/L 3compartmentss NA 95% Human Human +DTXSID20881237 Css NA 2.368 mg/L PBTK NA 50% Human Human +DTXSID20881237 Css NA 14.11 mg/L PBTK NA 95% Human Human +DTXSID20881237 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20881237 Fup 0.0237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20881237 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID20881237 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID20881237 TK.Half.Life NA 12.46 hours 1compartment NA NA Rat Human +DTXSID20881237 Css NA 0.4474 mg/L 3compartmentss NA 50% Rat Human +DTXSID20881237 Css NA 2.155 mg/L 3compartmentss NA 95% Rat Human +DTXSID20881237 Css NA 0.3075 mg/L PBTK NA 50% Rat Human +DTXSID20881237 Css NA 1.496 mg/L PBTK NA 95% Rat Human +DTXSID20881252 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20881252 Fup 0.778 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20881252 Vd NA 0.6993 L/kg 1compartment NA NA Human Human +DTXSID20881252 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20881252 TK.Half.Life NA 5.82 hours 1compartment NA NA Human Human +DTXSID20881252 Css NA 0.9902 mg/L 3compartmentss NA 50% Human Human +DTXSID20881252 Css NA 6.231 mg/L 3compartmentss NA 95% Human Human +DTXSID20881252 Css NA 0.8086 mg/L PBTK NA 50% Human Human +DTXSID20881252 Css NA 3.95 mg/L PBTK NA 95% Human Human +DTXSID20881252 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20881252 Fup 0.778 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20881252 Vd NA 0.7271 L/kg 1compartment NA NA Rat Human +DTXSID20881252 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20881252 TK.Half.Life NA 2.061 hours 1compartment NA NA Rat Human +DTXSID20881252 Css NA 0.0587 mg/L 3compartmentss NA 50% Rat Human +DTXSID20881252 Css NA 0.3554 mg/L 3compartmentss NA 95% Rat Human +DTXSID20881252 Css NA 0.0479 mg/L PBTK NA 50% Rat Human +DTXSID20881252 Css NA 0.2188 mg/L PBTK NA 95% Rat Human +DTXSID20904894 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20904894 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20904894 Vd NA 0.8362 L/kg 1compartment NA NA Human Human +DTXSID20904894 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID20904894 TK.Half.Life NA 25.31 hours 1compartment NA NA Human Human +DTXSID20904894 Css NA 1.294 mg/L 3compartmentss NA 50% Human Human +DTXSID20904894 Css NA 5.616 mg/L 3compartmentss NA 95% Human Human +DTXSID20904894 Css NA 0.9253 mg/L PBTK NA 50% Human Human +DTXSID20904894 Css NA 3.591 mg/L PBTK NA 95% Human Human +DTXSID20904894 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20904894 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20904894 Vd NA 0.8331 L/kg 1compartment NA NA Rat Human +DTXSID20904894 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20904894 TK.Half.Life NA 8.587 hours 1compartment NA NA Rat Human +DTXSID20904894 Css NA 0.006008 mg/L 3compartmentss NA 50% Rat Human +DTXSID20904894 Css NA 0.02241 mg/L 3compartmentss NA 95% Rat Human +DTXSID20904894 Css NA 0.004136 mg/L PBTK NA 50% Rat Human +DTXSID20904894 Css NA 0.01348 mg/L PBTK NA 95% Rat Human +DTXSID20904970 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID20904970 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20904970 Vd NA 2.202 L/kg 1compartment NA NA Human Human +DTXSID20904970 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID20904970 TK.Half.Life NA 21.15 hours 1compartment NA NA Human Human +DTXSID20904970 Css NA 1.303 mg/L 3compartmentss NA 50% Human Human +DTXSID20904970 Css NA 8.573 mg/L 3compartmentss NA 95% Human Human +DTXSID20904970 Css NA 0.8988 mg/L PBTK NA 50% Human Human +DTXSID20904970 Css NA 5.547 mg/L PBTK NA 95% Human Human +DTXSID20904970 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID20904970 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20904970 Vd NA 1.757 L/kg 1compartment NA NA Rat Human +DTXSID20904970 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID20904970 TK.Half.Life NA 7.477 hours 1compartment NA NA Rat Human +DTXSID20904970 Css NA 0.16 mg/L 3compartmentss NA 50% Rat Human +DTXSID20904970 Css NA 0.8252 mg/L 3compartmentss NA 95% Rat Human +DTXSID20904970 Css NA 0.109 mg/L PBTK NA 50% Rat Human +DTXSID20904970 Css NA 0.522 mg/L PBTK NA 95% Rat Human +DTXSID20905104 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20905104 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20905104 Vd NA 0.5883 L/kg 1compartment NA NA Human Human +DTXSID20905104 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20905104 TK.Half.Life NA 4.128 hours 1compartment NA NA Human Human +DTXSID20905104 Css NA 0.8846 mg/L 3compartmentss NA 50% Human Human +DTXSID20905104 Css NA 6.421 mg/L 3compartmentss NA 95% Human Human +DTXSID20905104 Css NA 0.5559 mg/L PBTK NA 50% Human Human +DTXSID20905104 Css NA 3.856 mg/L PBTK NA 95% Human Human +DTXSID20905104 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20905104 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20905104 Vd NA 0.4882 L/kg 1compartment NA NA Rat Human +DTXSID20905104 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20905104 TK.Half.Life NA 2.051 hours 1compartment NA NA Rat Human +DTXSID20905104 Css NA 0.04064 mg/L 3compartmentss NA 50% Rat Human +DTXSID20905104 Css NA 0.3265 mg/L 3compartmentss NA 95% Rat Human +DTXSID20905104 Css NA 0.02447 mg/L PBTK NA 50% Rat Human +DTXSID20905104 Css NA 0.1892 mg/L PBTK NA 95% Rat Human +DTXSID20926399 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20926399 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20926399 Vd NA 2.671 L/kg 1compartment NA NA Human Human +DTXSID20926399 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID20926399 TK.Half.Life NA 35.08 hours 1compartment NA NA Human Human +DTXSID20926399 Css NA 0.9504 mg/L 3compartmentss NA 50% Human Human +DTXSID20926399 Css NA 5.789 mg/L 3compartmentss NA 95% Human Human +DTXSID20926399 Css NA 1.09 mg/L PBTK NA 50% Human Human +DTXSID20926399 Css NA 4.384 mg/L PBTK NA 95% Human Human +DTXSID20926399 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20926399 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20926399 Vd NA 2.67 L/kg 1compartment NA NA Rat Human +DTXSID20926399 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID20926399 TK.Half.Life NA 11.94 hours 1compartment NA NA Rat Human +DTXSID20926399 Css NA 0.05753 mg/L 3compartmentss NA 50% Rat Human +DTXSID20926399 Css NA 0.3286 mg/L 3compartmentss NA 95% Rat Human +DTXSID20926399 Css NA 0.06799 mg/L PBTK NA 50% Rat Human +DTXSID20926399 Css NA 0.2413 mg/L PBTK NA 95% Rat Human +DTXSID20953024 Clint 158 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID20953024 Fup 0.164 NA NA Williamson 2020 NA Human Human +DTXSID20953024 Vd NA 2.555 L/kg 1compartment NA NA Human Human +DTXSID20953024 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20953024 TK.Half.Life NA 2.892 hours 1compartment NA NA Human Human +DTXSID20953024 Css NA 0.03266 mg/L 3compartmentss NA 50% Human Human +DTXSID20953024 Css NA 0.2676 mg/L 3compartmentss NA 95% Human Human +DTXSID20953024 Css NA 0.02314 mg/L PBTK NA 50% Human Human +DTXSID20953024 Css NA 0.1829 mg/L PBTK NA 95% Human Human +DTXSID20953024 Clint 158 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID20953024 Fup 0.164 NA NA Williamson 2020 NA Rat Human +DTXSID20953024 Vd NA 1.937 L/kg 1compartment NA NA Rat Human +DTXSID20953024 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20953024 TK.Half.Life NA 0.8787 hours 1compartment NA NA Rat Human +DTXSID20953024 Css NA 0.001199 mg/L 3compartmentss NA 50% Rat Human +DTXSID20953024 Css NA 0.01122 mg/L 3compartmentss NA 95% Rat Human +DTXSID20953024 Css NA 0.0008287 mg/L PBTK NA 50% Rat Human +DTXSID20953024 Css NA 0.007489 mg/L PBTK NA 95% Rat Human +DTXSID20963461 Clint 10.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20963461 Fup 0.417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20963461 Vd NA 1.695 L/kg 1compartment NA NA Human Human +DTXSID20963461 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20963461 TK.Half.Life NA 2.805 hours 1compartment NA NA Human Human +DTXSID20963461 Css NA 0.1123 mg/L 3compartmentss NA 50% Human Human +DTXSID20963461 Css NA 0.774 mg/L 3compartmentss NA 95% Human Human +DTXSID20963461 Css NA 0.09198 mg/L PBTK NA 50% Human Human +DTXSID20963461 Css NA 0.5513 mg/L PBTK NA 95% Human Human +DTXSID20963461 Clint 10.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20963461 Fup 0.417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20963461 Vd NA 1.417 L/kg 1compartment NA NA Rat Human +DTXSID20963461 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20963461 TK.Half.Life NA 1.151 hours 1compartment NA NA Rat Human +DTXSID20963461 Css NA 0.01325 mg/L 3compartmentss NA 50% Rat Human +DTXSID20963461 Css NA 0.07161 mg/L 3compartmentss NA 95% Rat Human +DTXSID20963461 Css NA 0.01091 mg/L PBTK NA 50% Rat Human +DTXSID20963461 Css NA 0.05004 mg/L PBTK NA 95% Rat Human +DTXSID20964175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20964175 Fup 0.21 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID20964175 Vd NA 1.414 L/kg 1compartment NA NA Human Human +DTXSID20964175 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID20964175 TK.Half.Life NA 2.182 hours 1compartment NA NA Human Human +DTXSID20964175 Css NA 0.0928 mg/L 3compartmentss NA 50% Human Human +DTXSID20964175 Css NA 0.7014 mg/L 3compartmentss NA 95% Human Human +DTXSID20964175 Css NA 0.0711 mg/L PBTK NA 50% Human Human +DTXSID20964175 Css NA 0.487 mg/L PBTK NA 95% Human Human +DTXSID20964175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20964175 Fup 0.21 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID20964175 Vd NA 1.306 L/kg 1compartment NA NA Rat Human +DTXSID20964175 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID20964175 TK.Half.Life NA 1.092 hours 1compartment NA NA Rat Human +DTXSID20964175 Css NA 0.01178 mg/L 3compartmentss NA 50% Rat Human +DTXSID20964175 Css NA 0.06553 mg/L 3compartmentss NA 95% Rat Human +DTXSID20964175 Css NA 0.009004 mg/L PBTK NA 50% Rat Human +DTXSID20964175 Css NA 0.0458 mg/L PBTK NA 95% Rat Human +DTXSID20966639 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20966639 Fup 0.0295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID20966639 Vd NA 5.757 L/kg 1compartment NA NA Human Human +DTXSID20966639 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID20966639 TK.Half.Life NA 164.8 hours 1compartment NA NA Human Human +DTXSID20966639 Css NA 2.636 mg/L 3compartmentss NA 50% Human Human +DTXSID20966639 Css NA 18 mg/L 3compartmentss NA 95% Human Human +DTXSID20966639 Css NA 2.266 mg/L PBTK NA 50% Human Human +DTXSID20966639 Css NA 14.65 mg/L PBTK NA 95% Human Human +DTXSID20966639 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20966639 Fup 0.0295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID20966639 Vd NA 4.422 L/kg 1compartment NA NA Rat Human +DTXSID20966639 Days.Css NA 18 Days PBTK NA NA Rat Human +DTXSID20966639 TK.Half.Life NA 22.42 hours 1compartment NA NA Rat Human +DTXSID20966639 Css NA 0.2649 mg/L 3compartmentss NA 50% Rat Human +DTXSID20966639 Css NA 1.342 mg/L 3compartmentss NA 95% Rat Human +DTXSID20966639 Css NA 0.2329 mg/L PBTK NA 50% Rat Human +DTXSID20966639 Css NA 1.085 mg/L PBTK NA 95% Rat Human +DTXSID301014178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID301014178 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID301014178 Vd NA 5.253 L/kg 1compartment NA NA Human Human +DTXSID301014178 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID301014178 TK.Half.Life NA 3.879 hours 1compartment NA NA Human Human +DTXSID301014178 Css NA 0.02221 mg/L 3compartmentss NA 50% Human Human +DTXSID301014178 Css NA 0.213 mg/L 3compartmentss NA 95% Human Human +DTXSID301014178 Css NA 0.03344 mg/L PBTK NA 50% Human Human +DTXSID301014178 Css NA 0.2417 mg/L PBTK NA 95% Human Human +DTXSID301014178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID301014178 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID301014178 Vd NA 5.307 L/kg 1compartment NA NA Rat Human +DTXSID301014178 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID301014178 TK.Half.Life NA 2.082 hours 1compartment NA NA Rat Human +DTXSID301014178 Css NA 0.002618 mg/L 3compartmentss NA 50% Rat Human +DTXSID301014178 Css NA 0.02021 mg/L 3compartmentss NA 95% Rat Human +DTXSID301014178 Css NA 0.004218 mg/L PBTK NA 50% Rat Human +DTXSID301014178 Css NA 0.02325 mg/L PBTK NA 95% Rat Human +DTXSID301029850 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID301029850 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID301029850 Vd NA 0.304 L/kg 1compartment NA NA Human Human +DTXSID301029850 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID301029850 TK.Half.Life NA 1.166 hours 1compartment NA NA Human Human +DTXSID301029850 Css NA 0.3445 mg/L 3compartmentss NA 50% Human Human +DTXSID301029850 Css NA 2.178 mg/L 3compartmentss NA 95% Human Human +DTXSID301029850 Css NA 0.2194 mg/L PBTK NA 50% Human Human +DTXSID301029850 Css NA 1.326 mg/L PBTK NA 95% Human Human +DTXSID301029850 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID301029850 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID301029850 Vd NA 0.3047 L/kg 1compartment NA NA Rat Human +DTXSID301029850 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID301029850 TK.Half.Life NA 0.6897 hours 1compartment NA NA Rat Human +DTXSID301029850 Css NA 0.009142 mg/L 3compartmentss NA 50% Rat Human +DTXSID301029850 Css NA 0.0708 mg/L 3compartmentss NA 95% Rat Human +DTXSID301029850 Css NA 0.005584 mg/L PBTK NA 50% Rat Human +DTXSID301029850 Css NA 0.04232 mg/L PBTK NA 95% Rat Human +DTXSID30152026 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30152026 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30152026 Vd NA 0.5045 L/kg 1compartment NA NA Human Human +DTXSID30152026 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30152026 TK.Half.Life NA 2.261 hours 1compartment NA NA Human Human +DTXSID30152026 Css NA 0.5522 mg/L 3compartmentss NA 50% Human Human +DTXSID30152026 Css NA 3.755 mg/L 3compartmentss NA 95% Human Human +DTXSID30152026 Css NA 0.3563 mg/L PBTK NA 50% Human Human +DTXSID30152026 Css NA 2.284 mg/L PBTK NA 95% Human Human +DTXSID30152026 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30152026 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30152026 Vd NA 0.4413 L/kg 1compartment NA NA Rat Human +DTXSID30152026 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30152026 TK.Half.Life NA 1.167 hours 1compartment NA NA Rat Human +DTXSID30152026 Css NA 0.06659 mg/L 3compartmentss NA 50% Rat Human +DTXSID30152026 Css NA 0.336 mg/L 3compartmentss NA 95% Rat Human +DTXSID30152026 Css NA 0.04218 mg/L PBTK NA 50% Rat Human +DTXSID30152026 Css NA 0.1982 mg/L PBTK NA 95% Rat Human +DTXSID30153230 Clint 3.31 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30153230 Fup 0.0561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30153230 Vd NA 2.589 L/kg 1compartment NA NA Human Human +DTXSID30153230 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID30153230 TK.Half.Life NA 100.4 hours 1compartment NA NA Human Human +DTXSID30153230 Css NA 5.234 mg/L 3compartmentss NA 50% Human Human +DTXSID30153230 Css NA 26.62 mg/L 3compartmentss NA 95% Human Human +DTXSID30153230 Css NA 3.553 mg/L PBTK NA 50% Human Human +DTXSID30153230 Css NA 17.37 mg/L PBTK NA 95% Human Human +DTXSID30153230 Clint 3.31 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30153230 Fup 0.0561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30153230 Vd NA 1.941 L/kg 1compartment NA NA Rat Human +DTXSID30153230 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID30153230 TK.Half.Life NA 21.56 hours 1compartment NA NA Rat Human +DTXSID30153230 Css NA 0.6192 mg/L 3compartmentss NA 50% Rat Human +DTXSID30153230 Css NA 2.344 mg/L 3compartmentss NA 95% Rat Human +DTXSID30153230 Css NA 0.4145 mg/L PBTK NA 50% Rat Human +DTXSID30153230 Css NA 1.484 mg/L PBTK NA 95% Rat Human +DTXSID30153457 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30153457 Fup 0.0103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30153457 Vd NA 1.742 L/kg 1compartment NA NA Human Human +DTXSID30153457 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID30153457 TK.Half.Life NA 25.98 hours 1compartment NA NA Human Human +DTXSID30153457 Css NA 2.332 mg/L 3compartmentss NA 50% Human Human +DTXSID30153457 Css NA 20.57 mg/L 3compartmentss NA 95% Human Human +DTXSID30153457 Css NA 1.48 mg/L PBTK NA 50% Human Human +DTXSID30153457 Css NA 12.5 mg/L PBTK NA 95% Human Human +DTXSID30153457 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30153457 Fup 0.0103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30153457 Vd NA 1.288 L/kg 1compartment NA NA Rat Human +DTXSID30153457 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID30153457 TK.Half.Life NA 9.224 hours 1compartment NA NA Rat Human +DTXSID30153457 Css NA 0.3061 mg/L 3compartmentss NA 50% Rat Human +DTXSID30153457 Css NA 2.238 mg/L 3compartmentss NA 95% Rat Human +DTXSID30153457 Css NA 0.187 mg/L PBTK NA 50% Rat Human +DTXSID30153457 Css NA 1.302 mg/L PBTK NA 95% Rat Human +DTXSID30166042 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30166042 Fup 0.353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30166042 Vd NA 1.84 L/kg 1compartment NA NA Human Human +DTXSID30166042 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30166042 TK.Half.Life NA 4.039 hours 1compartment NA NA Human Human +DTXSID30166042 Css NA 0.1595 mg/L 3compartmentss NA 50% Human Human +DTXSID30166042 Css NA 1.08 mg/L 3compartmentss NA 95% Human Human +DTXSID30166042 Css NA 0.1411 mg/L PBTK NA 50% Human Human +DTXSID30166042 Css NA 0.8008 mg/L PBTK NA 95% Human Human +DTXSID30166042 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30166042 Fup 0.353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30166042 Vd NA 1.766 L/kg 1compartment NA NA Rat Human +DTXSID30166042 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30166042 TK.Half.Life NA 2.143 hours 1compartment NA NA Rat Human +DTXSID30166042 Css NA 0.01864 mg/L 3compartmentss NA 50% Rat Human +DTXSID30166042 Css NA 0.09344 mg/L 3compartmentss NA 95% Rat Human +DTXSID30166042 Css NA 0.01647 mg/L PBTK NA 50% Rat Human +DTXSID30166042 Css NA 0.06817 mg/L PBTK NA 95% Rat Human DTXSID30166683 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID30166683 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID30166683 Vd NA 2.772 L/kg 1compartment NA NA Human Human -DTXSID30166683 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID30166683 TK.Half.Life NA 62.73 hours 1compartment NA NA Human Human -DTXSID30166683 Css NA 2.125 mg/L 3compartmentss NA 50% Human Human -DTXSID30166683 Css NA 10.24 mg/L 3compartmentss NA 95% Human Human -DTXSID30166683 Css NA 1.872 mg/L PBTK NA 50% Human Human -DTXSID30166683 Css NA 7.131 mg/L PBTK NA 95% Human Human +DTXSID30166683 Vd NA 2.233 L/kg 1compartment NA NA Human Human +DTXSID30166683 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID30166683 TK.Half.Life NA 25.35 hours 1compartment NA NA Human Human +DTXSID30166683 Css NA 0.9753 mg/L 3compartmentss NA 50% Human Human +DTXSID30166683 Css NA 6.208 mg/L 3compartmentss NA 95% Human Human +DTXSID30166683 Css NA 0.9304 mg/L PBTK NA 50% Human Human +DTXSID30166683 Css NA 4.357 mg/L PBTK NA 95% Human Human DTXSID30166683 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID30166683 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human -DTXSID30166683 Vd NA 2.17 L/kg 1compartment NA NA Rat Human -DTXSID30166683 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID30166683 TK.Half.Life NA 7.635 hours 1compartment NA NA Rat Human -DTXSID30166683 Css NA 0.5673 mg/L 3compartmentss NA 50% Rat Human -DTXSID30166683 Css NA 2.297 mg/L 3compartmentss NA 95% Rat Human -DTXSID30166683 Css NA 0.4839 mg/L PBTK NA 50% Rat Human -DTXSID30166683 Css NA 1.476 mg/L PBTK NA 95% Rat Human +DTXSID30166683 Vd NA 1.82 L/kg 1compartment NA NA Rat Human +DTXSID30166683 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30166683 TK.Half.Life NA 4.735 hours 1compartment NA NA Rat Human +DTXSID30166683 Css NA 0.05848 mg/L 3compartmentss NA 50% Rat Human +DTXSID30166683 Css NA 0.347 mg/L 3compartmentss NA 95% Rat Human +DTXSID30166683 Css NA 0.05705 mg/L PBTK NA 50% Rat Human +DTXSID30166683 Css NA 0.2298 mg/L PBTK NA 95% Rat Human +DTXSID30166724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30166724 Fup 0.93 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30166724 Vd NA 3.029 L/kg 1compartment NA NA Human Human +DTXSID30166724 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30166724 TK.Half.Life NA 2.875 hours 1compartment NA NA Human Human +DTXSID30166724 Css NA 0.02671 mg/L 3compartmentss NA 50% Human Human +DTXSID30166724 Css NA 0.1991 mg/L 3compartmentss NA 95% Human Human +DTXSID30166724 Css NA 0.03046 mg/L PBTK NA 50% Human Human +DTXSID30166724 Css NA 0.1893 mg/L PBTK NA 95% Human Human +DTXSID30166724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30166724 Fup 0.93 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30166724 Vd NA 3.073 L/kg 1compartment NA NA Rat Human +DTXSID30166724 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30166724 TK.Half.Life NA 1.571 hours 1compartment NA NA Rat Human +DTXSID30166724 Css NA 0.0002196 mg/L 3compartmentss NA 50% Rat Human +DTXSID30166724 Css NA 0.00169 mg/L 3compartmentss NA 95% Rat Human +DTXSID30166724 Css NA 0.0002564 mg/L PBTK NA 50% Rat Human +DTXSID30166724 Css NA 0.001533 mg/L PBTK NA 95% Rat Human +DTXSID30173135 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30173135 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30173135 Vd NA 1.849 L/kg 1compartment NA NA Human Human +DTXSID30173135 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30173135 TK.Half.Life NA 7.117 hours 1compartment NA NA Human Human +DTXSID30173135 Css NA 0.316 mg/L 3compartmentss NA 50% Human Human +DTXSID30173135 Css NA 1.796 mg/L 3compartmentss NA 95% Human Human +DTXSID30173135 Css NA 0.241 mg/L PBTK NA 50% Human Human +DTXSID30173135 Css NA 1.276 mg/L PBTK NA 95% Human Human +DTXSID30173135 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30173135 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30173135 Vd NA 1.443 L/kg 1compartment NA NA Rat Human +DTXSID30173135 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30173135 TK.Half.Life NA 2.485 hours 1compartment NA NA Rat Human +DTXSID30173135 Css NA 0.01423 mg/L 3compartmentss NA 50% Rat Human +DTXSID30173135 Css NA 0.09296 mg/L 3compartmentss NA 95% Rat Human +DTXSID30173135 Css NA 0.01084 mg/L PBTK NA 50% Rat Human +DTXSID30173135 Css NA 0.06422 mg/L PBTK NA 95% Rat Human +DTXSID30184983 Clint 35.48 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30184983 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30184983 Vd NA 1.349 L/kg 1compartment NA NA Human Human +DTXSID30184983 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30184983 TK.Half.Life NA 2.056 hours 1compartment NA NA Human Human +DTXSID30184983 Css NA 0.09514 mg/L 3compartmentss NA 50% Human Human +DTXSID30184983 Css NA 0.7418 mg/L 3compartmentss NA 95% Human Human +DTXSID30184983 Css NA 0.06601 mg/L PBTK NA 50% Human Human +DTXSID30184983 Css NA 0.4799 mg/L PBTK NA 95% Human Human +DTXSID30184983 Clint 35.48 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30184983 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30184983 Vd NA 1.062 L/kg 1compartment NA NA Rat Human +DTXSID30184983 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30184983 TK.Half.Life NA 0.8101 hours 1compartment NA NA Rat Human +DTXSID30184983 Css NA 0.01225 mg/L 3compartmentss NA 50% Rat Human +DTXSID30184983 Css NA 0.07208 mg/L 3compartmentss NA 95% Rat Human +DTXSID30184983 Css NA 0.00844 mg/L PBTK NA 50% Rat Human +DTXSID30184983 Css NA 0.0466 mg/L PBTK NA 95% Rat Human +DTXSID30187611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30187611 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30187611 Vd NA 0.5294 L/kg 1compartment NA NA Human Human +DTXSID30187611 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30187611 TK.Half.Life NA 1.346 hours 1compartment NA NA Human Human +DTXSID30187611 Css NA 0.273 mg/L 3compartmentss NA 50% Human Human +DTXSID30187611 Css NA 2.28 mg/L 3compartmentss NA 95% Human Human +DTXSID30187611 Css NA 0.1759 mg/L PBTK NA 50% Human Human +DTXSID30187611 Css NA 1.398 mg/L PBTK NA 95% Human Human +DTXSID30187611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30187611 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30187611 Vd NA 0.4619 L/kg 1compartment NA NA Rat Human +DTXSID30187611 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30187611 TK.Half.Life NA 0.6911 hours 1compartment NA NA Rat Human +DTXSID30187611 Css NA 0.03538 mg/L 3compartmentss NA 50% Rat Human +DTXSID30187611 Css NA 0.2365 mg/L 3compartmentss NA 95% Rat Human +DTXSID30187611 Css NA 0.02227 mg/L PBTK NA 50% Rat Human +DTXSID30187611 Css NA 0.1406 mg/L PBTK NA 95% Rat Human +DTXSID30199936 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30199936 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30199936 Vd NA 0.7201 L/kg 1compartment NA NA Human Human +DTXSID30199936 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30199936 TK.Half.Life NA 7.479 hours 1compartment NA NA Human Human +DTXSID30199936 Css NA 1.158 mg/L 3compartmentss NA 50% Human Human +DTXSID30199936 Css NA 7.914 mg/L 3compartmentss NA 95% Human Human +DTXSID30199936 Css NA 0.93 mg/L PBTK NA 50% Human Human +DTXSID30199936 Css NA 4.853 mg/L PBTK NA 95% Human Human +DTXSID30199936 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30199936 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30199936 Vd NA 0.7267 L/kg 1compartment NA NA Rat Human +DTXSID30199936 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30199936 TK.Half.Life NA 2.562 hours 1compartment NA NA Rat Human +DTXSID30199936 Css NA 0.07005 mg/L 3compartmentss NA 50% Rat Human +DTXSID30199936 Css NA 0.4514 mg/L 3compartmentss NA 95% Rat Human +DTXSID30199936 Css NA 0.0562 mg/L PBTK NA 50% Rat Human +DTXSID30199936 Css NA 0.275 mg/L PBTK NA 95% Rat Human DTXSID3020043 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020043 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020043 Vd NA 0.483 L/kg 1compartment NA NA Human Human +DTXSID3020043 Vd NA 0.4597 L/kg 1compartment NA NA Human Human DTXSID3020043 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020043 TK.Half.Life NA 3.127 hours 1compartment NA NA Human Human -DTXSID3020043 Css NA 0.9326 mg/L 3compartmentss NA 50% Human Human -DTXSID3020043 Css NA 5.728 mg/L 3compartmentss NA 95% Human Human -DTXSID3020043 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID3020043 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID3020043 TK.Half.Life NA 2.975 hours 1compartment NA NA Human Human +DTXSID3020043 Css NA 0.7955 mg/L 3compartmentss NA 50% Human Human +DTXSID3020043 Css NA 5.235 mg/L 3compartmentss NA 95% Human Human +DTXSID3020043 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID3020043 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID3020043 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020043 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020043 Vd NA 0.5107 L/kg 1compartment NA NA Rat Human +DTXSID3020043 Vd NA 0.4912 L/kg 1compartment NA NA Rat Human DTXSID3020043 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020043 TK.Half.Life NA 1.126 hours 1compartment NA NA Rat Human -DTXSID3020043 Css NA 0.237 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020043 Css NA 1.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020043 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID3020043 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID3020047 Clint NA 0.5981 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020047 Fup NA 0.7884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020047 Vd NA 1.096 L/kg 1compartment NA NA Human Human -DTXSID3020047 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020047 TK.Half.Life NA 4.878 hours 1compartment NA NA Human Human -DTXSID3020047 Css NA 0.486 mg/L 3compartmentss NA 50% Human Human -DTXSID3020047 Css NA 3.194 mg/L 3compartmentss NA 95% Human Human -DTXSID3020047 Css NA 0.4184 mg/L PBTK NA 50% Human Human -DTXSID3020047 Css NA 2.082 mg/L PBTK NA 95% Human Human -DTXSID3020047 Clint NA 0.5981 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020047 Fup NA 0.7884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020047 Vd NA 1.022 L/kg 1compartment NA NA Rat Human -DTXSID3020047 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020047 TK.Half.Life NA 1.973 hours 1compartment NA NA Rat Human -DTXSID3020047 Css NA 0.1689 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020047 Css NA 1.076 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020047 Css NA 0.1426 mg/L PBTK NA 50% Rat Human -DTXSID3020047 Css NA 0.6492 mg/L PBTK NA 95% Rat Human +DTXSID3020043 TK.Half.Life NA 1.083 hours 1compartment NA NA Rat Human +DTXSID3020043 Css NA 0.01472 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020043 Css NA 0.1057 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020043 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID3020043 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID3020091 Clint 4.41 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3020091 Fup NA 0.8408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020091 Vd NA 1.18 L/kg 1compartment NA NA Human Human +DTXSID3020091 Fup 0.461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020091 Vd NA 1.068 L/kg 1compartment NA NA Human Human DTXSID3020091 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020091 TK.Half.Life NA 1.635 hours 1compartment NA NA Human Human -DTXSID3020091 Css NA 0.1146 mg/L 3compartmentss NA 50% Human Human -DTXSID3020091 Css NA 0.9464 mg/L 3compartmentss NA 95% Human Human -DTXSID3020091 Css NA 0.1011 mg/L PBTK NA 50% Human Human -DTXSID3020091 Css NA 0.6613 mg/L PBTK NA 95% Human Human +DTXSID3020091 TK.Half.Life NA 2.446 hours 1compartment NA NA Human Human +DTXSID3020091 Css NA 0.1602 mg/L 3compartmentss NA 50% Human Human +DTXSID3020091 Css NA 1.137 mg/L 3compartmentss NA 95% Human Human +DTXSID3020091 Css NA 0.129 mg/L PBTK NA 50% Human Human +DTXSID3020091 Css NA 0.7819 mg/L PBTK NA 95% Human Human DTXSID3020091 Clint 4.41 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3020091 Fup NA 0.8408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020091 Vd NA 1.118 L/kg 1compartment NA NA Rat Human +DTXSID3020091 Fup 0.461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020091 Vd NA 0.9526 L/kg 1compartment NA NA Rat Human DTXSID3020091 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020091 TK.Half.Life NA 0.8084 hours 1compartment NA NA Rat Human -DTXSID3020091 Css NA 0.05323 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020091 Css NA 0.3626 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020091 Css NA 0.04686 mg/L PBTK NA 50% Rat Human -DTXSID3020091 Css NA 0.2322 mg/L PBTK NA 95% Rat Human -DTXSID3020093 Clint NA 66.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020093 Fup NA 0.7292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020093 Vd NA 1.12 L/kg 1compartment NA NA Human Human +DTXSID3020091 TK.Half.Life NA 1.167 hours 1compartment NA NA Rat Human +DTXSID3020091 Css NA 0.00524 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020091 Css NA 0.04468 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020091 Css NA 0.004112 mg/L PBTK NA 50% Rat Human +DTXSID3020091 Css NA 0.03032 mg/L PBTK NA 95% Rat Human +DTXSID3020093 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020093 Fup 0.385 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020093 Vd NA 1.558 L/kg 1compartment NA NA Human Human DTXSID3020093 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020093 TK.Half.Life NA 0.7262 hours 1compartment NA NA Human Human -DTXSID3020093 Css NA 0.009936 mg/L 3compartmentss NA 50% Human Human -DTXSID3020093 Css NA 0.1034 mg/L 3compartmentss NA 95% Human Human -DTXSID3020093 Css NA 0.008542 mg/L PBTK NA 50% Human Human -DTXSID3020093 Css NA 0.07367 mg/L PBTK NA 95% Human Human -DTXSID3020093 Clint NA 66.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020093 Fup NA 0.7292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020093 Vd NA 1.055 L/kg 1compartment NA NA Rat Human +DTXSID3020093 TK.Half.Life NA 1.856 hours 1compartment NA NA Human Human +DTXSID3020093 Css NA 0.05803 mg/L 3compartmentss NA 50% Human Human +DTXSID3020093 Css NA 0.4349 mg/L 3compartmentss NA 95% Human Human +DTXSID3020093 Css NA 0.04572 mg/L PBTK NA 50% Human Human +DTXSID3020093 Css NA 0.3094 mg/L PBTK NA 95% Human Human +DTXSID3020093 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020093 Fup 0.385 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020093 Vd NA 1.283 L/kg 1compartment NA NA Rat Human DTXSID3020093 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020093 TK.Half.Life NA 0.3107 hours 1compartment NA NA Rat Human -DTXSID3020093 Css NA 0.005044 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020093 Css NA 0.05028 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020093 Css NA 0.004304 mg/L PBTK NA 50% Rat Human -DTXSID3020093 Css NA 0.03515 mg/L PBTK NA 95% Rat Human -DTXSID3020095 Clint NA 5.156 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020095 Fup NA 0.0953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020095 Vd NA 2.392 L/kg 1compartment NA NA Human Human -DTXSID3020095 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3020095 TK.Half.Life NA 34.26 hours 1compartment NA NA Human Human -DTXSID3020095 Css NA 1.932 mg/L 3compartmentss NA 50% Human Human -DTXSID3020095 Css NA 10.61 mg/L 3compartmentss NA 95% Human Human -DTXSID3020095 Css NA 1.324 mg/L PBTK NA 50% Human Human -DTXSID3020095 Css NA 6.911 mg/L PBTK NA 95% Human Human -DTXSID3020095 Clint NA 5.156 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020095 Fup NA 0.0953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020095 Vd NA 1.803 L/kg 1compartment NA NA Rat Human -DTXSID3020095 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3020095 TK.Half.Life NA 8.783 hours 1compartment NA NA Rat Human -DTXSID3020095 Css NA 1.01 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020095 Css NA 4.013 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020095 Css NA 0.6558 mg/L PBTK NA 50% Rat Human -DTXSID3020095 Css NA 2.474 mg/L PBTK NA 95% Rat Human -DTXSID3020097 Clint NA 502.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020097 Fup NA 0.0201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020097 Vd NA 2.51 L/kg 1compartment NA NA Human Human -DTXSID3020097 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020097 TK.Half.Life NA 3.401 hours 1compartment NA NA Human Human -DTXSID3020097 Css NA 0.07747 mg/L 3compartmentss NA 50% Human Human -DTXSID3020097 Css NA 0.5823 mg/L 3compartmentss NA 95% Human Human -DTXSID3020097 Css NA 0.05129 mg/L PBTK NA 50% Human Human -DTXSID3020097 Css NA 0.3723 mg/L PBTK NA 95% Human Human -DTXSID3020097 Clint NA 502.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020097 Fup NA 0.0201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020097 Vd NA 1.873 L/kg 1compartment NA NA Rat Human -DTXSID3020097 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020097 TK.Half.Life NA 1.004 hours 1compartment NA NA Rat Human -DTXSID3020097 Css NA 0.0437 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020097 Css NA 0.2821 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020097 Css NA 0.0274 mg/L PBTK NA 50% Rat Human -DTXSID3020097 Css NA 0.1726 mg/L PBTK NA 95% Rat Human -DTXSID3020099 Clint NA 58.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020099 Fup NA 0.0161 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020099 Vd NA 0.2212 L/kg 1compartment NA NA Human Human +DTXSID3020093 TK.Half.Life NA 0.7386 hours 1compartment NA NA Rat Human +DTXSID3020093 Css NA 0.007111 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020093 Css NA 0.04118 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020093 Css NA 0.005672 mg/L PBTK NA 50% Rat Human +DTXSID3020093 Css NA 0.02922 mg/L PBTK NA 95% Rat Human +DTXSID3020095 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020095 Fup 0.0677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020095 Vd NA 1.916 L/kg 1compartment NA NA Human Human +DTXSID3020095 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3020095 TK.Half.Life NA 8.117 hours 1compartment NA NA Human Human +DTXSID3020095 Css NA 0.5297 mg/L 3compartmentss NA 50% Human Human +DTXSID3020095 Css NA 3.718 mg/L 3compartmentss NA 95% Human Human +DTXSID3020095 Css NA 0.3501 mg/L PBTK NA 50% Human Human +DTXSID3020095 Css NA 2.354 mg/L PBTK NA 95% Human Human +DTXSID3020095 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020095 Fup 0.0677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020095 Vd 1.5 1.442 L/kg 1compartment National Toxicology Program NA Rat Human +DTXSID3020095 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3020095 TK.Half.Life 0.12 2.751 hours 1compartment National Toxicology Program NA Rat Human +DTXSID3020095 Css 0.0045 0.06825 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID3020095 Css 0.0045 0.3884 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID3020095 Css 0.0045 0.04416 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID3020095 Css 0.0045 0.2434 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID3020097 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020097 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020097 Vd NA 2.21 L/kg 1compartment NA NA Human Human +DTXSID3020097 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3020097 TK.Half.Life NA 33.18 hours 1compartment NA NA Human Human +DTXSID3020097 Css NA 2.254 mg/L 3compartmentss NA 50% Human Human +DTXSID3020097 Css NA 17.32 mg/L 3compartmentss NA 95% Human Human +DTXSID3020097 Css NA 1.46 mg/L PBTK NA 50% Human Human +DTXSID3020097 Css NA 10.83 mg/L PBTK NA 95% Human Human +DTXSID3020097 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020097 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020097 Vd NA 1.641 L/kg 1compartment NA NA Rat Human +DTXSID3020097 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3020097 TK.Half.Life NA 9.631 hours 1compartment NA NA Rat Human +DTXSID3020097 Css NA 0.2881 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020097 Css NA 1.945 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020097 Css NA 0.182 mg/L PBTK NA 50% Rat Human +DTXSID3020097 Css NA 1.197 mg/L PBTK NA 95% Rat Human +DTXSID3020099 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020099 Fup 0.0807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020099 Vd NA 0.4567 L/kg 1compartment NA NA Human Human DTXSID3020099 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020099 TK.Half.Life NA 1.102 hours 1compartment NA NA Human Human -DTXSID3020099 Css NA 0.784 mg/L 3compartmentss NA 50% Human Human -DTXSID3020099 Css NA 8.016 mg/L 3compartmentss NA 95% Human Human -DTXSID3020099 Css NA 0.4657 mg/L PBTK NA 50% Human Human -DTXSID3020099 Css NA 4.599 mg/L PBTK NA 95% Human Human -DTXSID3020099 Clint NA 58.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020099 Fup NA 0.0161 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020099 Vd NA 0.2023 L/kg 1compartment NA NA Rat Human +DTXSID3020099 TK.Half.Life NA 1.345 hours 1compartment NA NA Human Human +DTXSID3020099 Css NA 0.3415 mg/L 3compartmentss NA 50% Human Human +DTXSID3020099 Css NA 2.784 mg/L 3compartmentss NA 95% Human Human +DTXSID3020099 Css NA 0.2238 mg/L PBTK NA 50% Human Human +DTXSID3020099 Css NA 1.736 mg/L PBTK NA 95% Human Human +DTXSID3020099 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020099 Fup 0.0807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020099 Vd NA 0.4332 L/kg 1compartment NA NA Rat Human DTXSID3020099 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020099 TK.Half.Life NA 0.6472 hours 1compartment NA NA Rat Human -DTXSID3020099 Css NA 0.448 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020099 Css NA 3.802 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020099 Css NA 0.2446 mg/L PBTK NA 50% Rat Human -DTXSID3020099 Css NA 2.058 mg/L PBTK NA 95% Rat Human -DTXSID3020120 Clint NA 316.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020120 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020120 Vd NA 2.113 L/kg 1compartment NA NA Human Human -DTXSID3020120 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020120 TK.Half.Life NA 4.065 hours 1compartment NA NA Human Human -DTXSID3020120 Css NA 0.1718 mg/L 3compartmentss NA 50% Human Human -DTXSID3020120 Css NA 1.45 mg/L 3compartmentss NA 95% Human Human -DTXSID3020120 Css NA 0.1105 mg/L PBTK NA 50% Human Human -DTXSID3020120 Css NA 0.8899 mg/L PBTK NA 95% Human Human -DTXSID3020120 Clint NA 316.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020120 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020120 Vd NA 1.568 L/kg 1compartment NA NA Rat Human -DTXSID3020120 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020120 TK.Half.Life NA 1.281 hours 1compartment NA NA Rat Human -DTXSID3020120 Css NA 0.09786 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020120 Css NA 0.6989 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020120 Css NA 0.05942 mg/L PBTK NA 50% Rat Human -DTXSID3020120 Css NA 0.4009 mg/L PBTK NA 95% Rat Human +DTXSID3020099 TK.Half.Life NA 0.7755 hours 1compartment NA NA Rat Human +DTXSID3020099 Css NA 0.04461 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020099 Css NA 0.2784 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020099 Css NA 0.02848 mg/L PBTK NA 50% Rat Human +DTXSID3020099 Css NA 0.1661 mg/L PBTK NA 95% Rat Human +DTXSID3020120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020120 Fup 0.0342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020120 Vd NA 3.089 L/kg 1compartment NA NA Human Human +DTXSID3020120 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID3020120 TK.Half.Life NA 68.9 hours 1compartment NA NA Human Human +DTXSID3020120 Css NA 2.325 mg/L 3compartmentss NA 50% Human Human +DTXSID3020120 Css NA 15.82 mg/L 3compartmentss NA 95% Human Human +DTXSID3020120 Css NA 1.608 mg/L PBTK NA 50% Human Human +DTXSID3020120 Css NA 10.38 mg/L PBTK NA 95% Human Human +DTXSID3020120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020120 Fup 0.0342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020120 Vd NA 2.314 L/kg 1compartment NA NA Rat Human +DTXSID3020120 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID3020120 TK.Half.Life NA 9.81 hours 1compartment NA NA Rat Human +DTXSID3020120 Css NA 0.1188 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020120 Css NA 0.8202 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020120 Css NA 0.08019 mg/L PBTK NA 50% Rat Human +DTXSID3020120 Css NA 0.535 mg/L PBTK NA 95% Rat Human DTXSID3020122 Clint 32.63 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3020122 Fup 0.2137 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3020122 Vd NA 2.086 L/kg 1compartment NA NA Human Human DTXSID3020122 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020122 TK.Half.Life NA 3.349 hours 1compartment NA NA Human Human -DTXSID3020122 Css NA 0.1042 mg/L 3compartmentss NA 50% Human Human -DTXSID3020122 Css NA 0.7085 mg/L 3compartmentss NA 95% Human Human -DTXSID3020122 Css NA 0.0757 mg/L PBTK NA 50% Human Human -DTXSID3020122 Css NA 0.4971 mg/L PBTK NA 95% Human Human +DTXSID3020122 Css NA 0.09984 mg/L 3compartmentss NA 50% Human Human +DTXSID3020122 Css NA 0.684 mg/L 3compartmentss NA 95% Human Human +DTXSID3020122 Css NA 0.07294 mg/L PBTK NA 50% Human Human +DTXSID3020122 Css NA 0.4726 mg/L PBTK NA 95% Human Human DTXSID3020122 Clint 32.63 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3020122 Fup 0.2137 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3020122 Vd NA 1.608 L/kg 1compartment NA NA Rat Human DTXSID3020122 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020122 TK.Half.Life NA 1.119 hours 1compartment NA NA Rat Human -DTXSID3020122 Css NA 0.05751 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020122 Css NA 0.2952 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020122 Css NA 0.04024 mg/L PBTK NA 50% Rat Human -DTXSID3020122 Css NA 0.199 mg/L PBTK NA 95% Rat Human -DTXSID3020128 Clint NA 0.1063 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020128 Fup NA 0.6543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020128 Vd NA 0.8685 L/kg 1compartment NA NA Human Human +DTXSID3020122 Css NA 0.01265 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020122 Css NA 0.06858 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020122 Css NA 0.009218 mg/L PBTK NA 50% Rat Human +DTXSID3020122 Css NA 0.04782 mg/L PBTK NA 95% Rat Human +DTXSID3020128 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020128 Fup 0.787 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020128 Vd NA 0.9594 L/kg 1compartment NA NA Human Human DTXSID3020128 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020128 TK.Half.Life NA 7.447 hours 1compartment NA NA Human Human -DTXSID3020128 Css NA 0.936 mg/L 3compartmentss NA 50% Human Human -DTXSID3020128 Css NA 6.205 mg/L 3compartmentss NA 95% Human Human -DTXSID3020128 Css NA 0.7788 mg/L PBTK NA 50% Human Human -DTXSID3020128 Css NA 3.932 mg/L PBTK NA 95% Human Human -DTXSID3020128 Clint NA 0.1063 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020128 Fup NA 0.6543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020128 Vd NA 0.8422 L/kg 1compartment NA NA Rat Human +DTXSID3020128 TK.Half.Life NA 8.058 hours 1compartment NA NA Human Human +DTXSID3020128 Css NA 0.9402 mg/L 3compartmentss NA 50% Human Human +DTXSID3020128 Css NA 6.014 mg/L 3compartmentss NA 95% Human Human +DTXSID3020128 Css NA 0.8102 mg/L PBTK NA 50% Human Human +DTXSID3020128 Css NA 3.938 mg/L PBTK NA 95% Human Human +DTXSID3020128 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020128 Fup 0.787 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020128 Vd NA 0.9337 L/kg 1compartment NA NA Rat Human DTXSID3020128 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020128 TK.Half.Life NA 2.626 hours 1compartment NA NA Rat Human -DTXSID3020128 Css NA 0.2668 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020128 Css NA 1.799 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020128 Css NA 0.2143 mg/L PBTK NA 50% Rat Human -DTXSID3020128 Css NA 1.064 mg/L PBTK NA 95% Rat Human +DTXSID3020128 TK.Half.Life NA 2.629 hours 1compartment NA NA Rat Human +DTXSID3020128 Css NA 0.05532 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020128 Css NA 0.3434 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020128 Css NA 0.04797 mg/L PBTK NA 50% Rat Human +DTXSID3020128 Css NA 0.2157 mg/L PBTK NA 95% Rat Human DTXSID3020207 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020207 Fup 0.00043 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020207 Vd NA 0.1884 L/kg 1compartment NA NA Human Human -DTXSID3020207 Days.Css NA 773 Days PBTK NA NA Human Human +DTXSID3020207 Days.Css NA 775 Days PBTK NA NA Human Human DTXSID3020207 TK.Half.Life NA 2835 hours 1compartment NA NA Human Human -DTXSID3020207 Css NA 2603 mg/L 3compartmentss NA 50% Human Human -DTXSID3020207 Css NA 10670 mg/L 3compartmentss NA 95% Human Human -DTXSID3020207 Css NA 1535 mg/L PBTK NA 50% Human Human -DTXSID3020207 Css NA 6141 mg/L PBTK NA 95% Human Human +DTXSID3020207 Css NA 2516 mg/L 3compartmentss NA 50% Human Human +DTXSID3020207 Css NA 10300 mg/L 3compartmentss NA 95% Human Human +DTXSID3020207 Css NA 1466 mg/L PBTK NA 50% Human Human +DTXSID3020207 Css NA 5947 mg/L PBTK NA 95% Human Human DTXSID3020207 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3020207 Fup 0.00043 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3020207 Vd NA 0.1833 L/kg 1compartment NA NA Rat Human -DTXSID3020207 Days.Css NA 252 Days PBTK NA NA Rat Human +DTXSID3020207 Days.Css NA 251 Days PBTK NA NA Rat Human DTXSID3020207 TK.Half.Life NA 939.7 hours 1compartment NA NA Rat Human -DTXSID3020207 Css NA 736.7 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020207 Css NA 2448 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020207 Css NA 401.1 mg/L PBTK NA 50% Rat Human -DTXSID3020207 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID3020207 Css NA 165.9 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020207 Css NA 554.5 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020207 Css NA 93.56 mg/L PBTK NA 50% Rat Human +DTXSID3020207 Css NA 310.9 mg/L PBTK NA 95% Rat Human DTXSID3020209 Clint 39.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020209 Fup 0.04157 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020209 Vd NA 2.551 L/kg 1compartment NA NA Human Human DTXSID3020209 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020209 TK.Half.Life NA 9.195 hours 1compartment NA NA Human Human -DTXSID3020209 Css NA 0.3661 mg/L 3compartmentss NA 50% Human Human -DTXSID3020209 Css NA 3.238 mg/L 3compartmentss NA 95% Human Human -DTXSID3020209 Css NA 0.3232 mg/L PBTK NA 50% Human Human -DTXSID3020209 Css NA 2.433 mg/L PBTK NA 95% Human Human +DTXSID3020209 Css NA 0.3646 mg/L 3compartmentss NA 50% Human Human +DTXSID3020209 Css NA 3.053 mg/L 3compartmentss NA 95% Human Human +DTXSID3020209 Css NA 0.3196 mg/L PBTK NA 50% Human Human +DTXSID3020209 Css NA 2.332 mg/L PBTK NA 95% Human Human DTXSID3020209 Clint 271 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID3020209 Fup 0.0356 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID3020209 Vd NA 1.997 L/kg 1compartment NA NA Rat Rat DTXSID3020209 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID3020209 TK.Half.Life NA 0.9713 hours 1compartment NA NA Rat Rat -DTXSID3020209 Css NA 0.03292 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3020209 Css NA 0.221 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3020209 Css NA 0.02765 mg/L PBTK NA 50% Rat Rat -DTXSID3020209 Css NA 0.1646 mg/L PBTK NA 95% Rat Rat +DTXSID3020209 Css NA 0.007169 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3020209 Css NA 0.05314 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3020209 Css NA 0.006237 mg/L PBTK NA 50% Rat Rat +DTXSID3020209 Css NA 0.04093 mg/L PBTK NA 95% Rat Rat DTXSID3020253 Clint NA 343.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020253 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020253 Vd NA 2065 L/kg 1compartment NA NA Human Human -DTXSID3020253 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID3020253 TK.Half.Life NA 3881 hours 1compartment NA NA Human Human -DTXSID3020253 Css NA 0.0004447 mg/L 3compartmentss NA 50% Human Human -DTXSID3020253 Css NA 0.002773 mg/L 3compartmentss NA 95% Human Human -DTXSID3020253 Css NA 0.1563 mg/L PBTK NA 50% Human Human -DTXSID3020253 Css NA 0.8895 mg/L PBTK NA 95% Human Human +DTXSID3020253 Vd NA 10.3 L/kg 1compartment NA NA Human Human +DTXSID3020253 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3020253 TK.Half.Life NA 24.01 hours 1compartment NA NA Human Human +DTXSID3020253 Css NA 0.1238 mg/L 3compartmentss NA 50% Human Human +DTXSID3020253 Css NA 0.7745 mg/L 3compartmentss NA 95% Human Human +DTXSID3020253 Css NA 0.1494 mg/L PBTK NA 50% Human Human +DTXSID3020253 Css NA 0.9235 mg/L PBTK NA 95% Human Human DTXSID3020253 Clint NA 343.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020253 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020253 Vd NA 1913 L/kg 1compartment NA NA Rat Human -DTXSID3020253 Days.Css NA 688 Days PBTK NA NA Rat Human -DTXSID3020253 TK.Half.Life NA 635.9 hours 1compartment NA NA Rat Human -DTXSID3020253 Css NA 0.0002288 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020253 Css NA 0.0009771 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020253 Css NA 0.08464 mg/L PBTK NA 50% Rat Human -DTXSID3020253 Css NA 0.3625 mg/L PBTK NA 95% Rat Human +DTXSID3020253 Vd NA 8.121 L/kg 1compartment NA NA Rat Human +DTXSID3020253 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3020253 TK.Half.Life NA 4.311 hours 1compartment NA NA Rat Human +DTXSID3020253 Css NA 0.01562 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020253 Css NA 0.07857 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020253 Css NA 0.01968 mg/L PBTK NA 50% Rat Human +DTXSID3020253 Css NA 0.1009 mg/L PBTK NA 95% Rat Human DTXSID3020257 Clint 42.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3020257 Fup 0.0268 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3020257 Vd NA 0.2288 L/kg 1compartment NA NA Human Human DTXSID3020257 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020257 TK.Half.Life NA 0.9832 hours 1compartment NA NA Human Human -DTXSID3020257 Css NA 0.5436 mg/L 3compartmentss NA 50% Human Human -DTXSID3020257 Css NA 5.287 mg/L 3compartmentss NA 95% Human Human -DTXSID3020257 Css NA 0.322 mg/L PBTK NA 50% Human Human -DTXSID3020257 Css NA 3.096 mg/L PBTK NA 95% Human Human +DTXSID3020257 Css NA 0.5348 mg/L 3compartmentss NA 50% Human Human +DTXSID3020257 Css NA 5.093 mg/L 3compartmentss NA 95% Human Human +DTXSID3020257 Css NA 0.3158 mg/L PBTK NA 50% Human Human +DTXSID3020257 Css NA 2.948 mg/L PBTK NA 95% Human Human DTXSID3020257 Clint 42.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3020257 Fup 0.0268 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3020257 Vd NA 0.2169 L/kg 1compartment NA NA Rat Human DTXSID3020257 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020257 TK.Half.Life NA 0.5904 hours 1compartment NA NA Rat Human -DTXSID3020257 Css NA 0.3134 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020257 Css NA 2.315 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020257 Css NA 0.1732 mg/L PBTK NA 50% Rat Human -DTXSID3020257 Css NA 1.265 mg/L PBTK NA 95% Rat Human -DTXSID3020330 Clint NA 31.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020330 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020330 Vd NA 0.5572 L/kg 1compartment NA NA Human Human +DTXSID3020257 Css NA 0.07084 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020257 Css NA 0.5165 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020257 Css NA 0.04054 mg/L PBTK NA 50% Rat Human +DTXSID3020257 Css NA 0.2935 mg/L PBTK NA 95% Rat Human +DTXSID3020330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020330 Fup 0.0475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020330 Vd NA 1.096 L/kg 1compartment NA NA Human Human DTXSID3020330 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020330 TK.Half.Life NA 2.516 hours 1compartment NA NA Human Human -DTXSID3020330 Css NA 0.6886 mg/L 3compartmentss NA 50% Human Human -DTXSID3020330 Css NA 6.252 mg/L 3compartmentss NA 95% Human Human -DTXSID3020330 Css NA 0.4158 mg/L PBTK NA 50% Human Human -DTXSID3020330 Css NA 3.741 mg/L PBTK NA 95% Human Human -DTXSID3020330 Clint NA 31.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020330 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020330 Vd NA 0.4397 L/kg 1compartment NA NA Rat Human +DTXSID3020330 TK.Half.Life NA 5.005 hours 1compartment NA NA Human Human +DTXSID3020330 Css NA 0.6218 mg/L 3compartmentss NA 50% Human Human +DTXSID3020330 Css NA 5.181 mg/L 3compartmentss NA 95% Human Human +DTXSID3020330 Css NA 0.3908 mg/L PBTK NA 50% Human Human +DTXSID3020330 Css NA 3.092 mg/L PBTK NA 95% Human Human +DTXSID3020330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020330 Fup 0.0475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020330 Vd NA 0.8317 L/kg 1compartment NA NA Rat Human DTXSID3020330 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020330 TK.Half.Life NA 1.227 hours 1compartment NA NA Rat Human -DTXSID3020330 Css NA 0.3956 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020330 Css NA 2.983 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020330 Css NA 0.2232 mg/L PBTK NA 50% Rat Human -DTXSID3020330 Css NA 1.643 mg/L PBTK NA 95% Rat Human +DTXSID3020330 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human +DTXSID3020330 Css NA 0.08198 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020330 Css NA 0.5328 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020330 Css NA 0.04982 mg/L PBTK NA 50% Rat Human +DTXSID3020330 Css NA 0.309 mg/L PBTK NA 95% Rat Human DTXSID3020332 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020332 Fup NA 0.8331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020332 Vd NA 0.6486 L/kg 1compartment NA NA Human Human DTXSID3020332 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020332 TK.Half.Life NA 5.037 hours 1compartment NA NA Human Human -DTXSID3020332 Css NA 0.9942 mg/L 3compartmentss NA 50% Human Human -DTXSID3020332 Css NA 5.842 mg/L 3compartmentss NA 95% Human Human -DTXSID3020332 Css NA 0.7968 mg/L PBTK NA 50% Human Human -DTXSID3020332 Css NA 3.742 mg/L PBTK NA 95% Human Human +DTXSID3020332 Css NA 0.8386 mg/L 3compartmentss NA 50% Human Human +DTXSID3020332 Css NA 5.162 mg/L 3compartmentss NA 95% Human Human +DTXSID3020332 Css NA 0.6801 mg/L PBTK NA 50% Human Human +DTXSID3020332 Css NA 3.317 mg/L PBTK NA 95% Human Human DTXSID3020332 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020332 Fup NA 0.8331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020332 Vd NA 0.6897 L/kg 1compartment NA NA Rat Human DTXSID3020332 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020332 TK.Half.Life NA 1.826 hours 1compartment NA NA Rat Human -DTXSID3020332 Css NA 0.2544 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020332 Css NA 1.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020332 Css NA 0.1983 mg/L PBTK NA 50% Rat Human -DTXSID3020332 Css NA 0.8685 mg/L PBTK NA 95% Rat Human +DTXSID3020332 Css NA 0.01564 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020332 Css NA 0.1214 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020332 Css NA 0.01214 mg/L PBTK NA 50% Rat Human +DTXSID3020332 Css NA 0.07766 mg/L PBTK NA 95% Rat Human DTXSID3020336 Clint 868 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3020336 Fup 7.42e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3020336 Vd NA 0.1955 L/kg 1compartment NA NA Human Human +DTXSID3020336 Vd NA 0.1862 L/kg 1compartment NA NA Human Human DTXSID3020336 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020336 TK.Half.Life NA 6.017 hours 1compartment NA NA Human Human -DTXSID3020336 Css NA 0.06654 mg/L 3compartmentss NA 50% Human Human -DTXSID3020336 Css NA 0.8458 mg/L 3compartmentss NA 95% Human Human -DTXSID3020336 Css NA 0.04021 mg/L PBTK NA 50% Human Human -DTXSID3020336 Css NA 0.5032 mg/L PBTK NA 95% Human Human +DTXSID3020336 TK.Half.Life NA 6.129 hours 1compartment NA NA Human Human +DTXSID3020336 Css NA 0.06301 mg/L 3compartmentss NA 50% Human Human +DTXSID3020336 Css NA 0.8546 mg/L 3compartmentss NA 95% Human Human +DTXSID3020336 Css NA 0.03781 mg/L PBTK NA 50% Human Human +DTXSID3020336 Css NA 0.5039 mg/L PBTK NA 95% Human Human DTXSID3020336 Clint 868 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3020336 Fup 7.42e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3020336 Vd NA 0.1762 L/kg 1compartment NA NA Rat Human +DTXSID3020336 Vd NA 0.1713 L/kg 1compartment NA NA Rat Human DTXSID3020336 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020336 TK.Half.Life NA 3.759 hours 1compartment NA NA Rat Human -DTXSID3020336 Css NA 0.0363 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020336 Css NA 0.4274 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020336 Css NA 0.02067 mg/L PBTK NA 50% Rat Human -DTXSID3020336 Css NA 0.2352 mg/L PBTK NA 95% Rat Human -DTXSID3020380 Clint NA 45.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020380 Fup NA 0.0755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020380 Vd NA 2.888 L/kg 1compartment NA NA Human Human -DTXSID3020380 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020380 TK.Half.Life NA 13.31 hours 1compartment NA NA Human Human -DTXSID3020380 Css NA 0.5047 mg/L 3compartmentss NA 50% Human Human -DTXSID3020380 Css NA 3.224 mg/L 3compartmentss NA 95% Human Human -DTXSID3020380 Css NA 0.3481 mg/L PBTK NA 50% Human Human -DTXSID3020380 Css NA 2.162 mg/L PBTK NA 95% Human Human -DTXSID3020380 Clint NA 45.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020380 Fup NA 0.0755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020380 Vd NA 2.168 L/kg 1compartment NA NA Rat Human -DTXSID3020380 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020380 TK.Half.Life NA 2.702 hours 1compartment NA NA Rat Human -DTXSID3020380 Css NA 0.281 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020380 Css NA 1.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020380 Css NA 0.1858 mg/L PBTK NA 50% Rat Human -DTXSID3020380 Css NA 0.961 mg/L PBTK NA 95% Rat Human +DTXSID3020336 TK.Half.Life NA 3.914 hours 1compartment NA NA Rat Human +DTXSID3020336 Css NA 0.008079 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020336 Css NA 0.1011 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020336 Css NA 0.004713 mg/L PBTK NA 50% Rat Human +DTXSID3020336 Css NA 0.05751 mg/L PBTK NA 95% Rat Human +DTXSID3020380 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020380 Fup 0.0289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020380 Vd NA 3.064 L/kg 1compartment NA NA Human Human +DTXSID3020380 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID3020380 TK.Half.Life NA 65.51 hours 1compartment NA NA Human Human +DTXSID3020380 Css NA 2.564 mg/L 3compartmentss NA 50% Human Human +DTXSID3020380 Css NA 17.06 mg/L 3compartmentss NA 95% Human Human +DTXSID3020380 Css NA 1.782 mg/L PBTK NA 50% Human Human +DTXSID3020380 Css NA 11.52 mg/L PBTK NA 95% Human Human +DTXSID3020380 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020380 Fup 0.0289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020380 Vd NA 2.295 L/kg 1compartment NA NA Rat Human +DTXSID3020380 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID3020380 TK.Half.Life NA 9.606 hours 1compartment NA NA Rat Human +DTXSID3020380 Css NA 0.3324 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020380 Css NA 1.947 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020380 Css NA 0.2275 mg/L PBTK NA 50% Rat Human +DTXSID3020380 Css NA 1.287 mg/L PBTK NA 95% Rat Human DTXSID3020384 Clint 1.791 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID3020384 Fup 0.32 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID3020384 Vd NA 1.059 L/kg 1compartment NA NA Human Human DTXSID3020384 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020384 TK.Half.Life NA 6.161 hours 1compartment NA NA Human Human -DTXSID3020384 Css NA 0.5216 mg/L 3compartmentss NA 50% Human Human -DTXSID3020384 Css NA 2.712 mg/L 3compartmentss NA 95% Human Human -DTXSID3020384 Css NA 0.4696 mg/L PBTK NA 50% Human Human -DTXSID3020384 Css NA 1.969 mg/L PBTK NA 95% Human Human +DTXSID3020384 Css NA 0.4914 mg/L 3compartmentss NA 50% Human Human +DTXSID3020384 Css NA 2.072 mg/L 3compartmentss NA 95% Human Human +DTXSID3020384 Css NA 0.4559 mg/L PBTK NA 50% Human Human +DTXSID3020384 Css NA 1.925 mg/L PBTK NA 95% Human Human DTXSID3020384 Clint 1.791 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID3020384 Fup 0.32 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human DTXSID3020384 Vd NA 0.5448 L/kg 1compartment NA NA Rat Human DTXSID3020384 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020384 TK.Half.Life NA 3.779 hours 1compartment NA NA Rat Human -DTXSID3020384 Css NA 0.6267 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020384 Css NA 3.366 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020384 Css NA 0.5326 mg/L PBTK NA 50% Rat Human -DTXSID3020384 Css NA 2.145 mg/L PBTK NA 95% Rat Human -DTXSID3020419 Clint NA 252.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020419 Fup NA 0.076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020419 Vd NA 2.884 L/kg 1compartment NA NA Human Human -DTXSID3020419 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020419 TK.Half.Life NA 4.292 hours 1compartment NA NA Human Human -DTXSID3020419 Css NA 0.08977 mg/L 3compartmentss NA 50% Human Human -DTXSID3020419 Css NA 0.5939 mg/L 3compartmentss NA 95% Human Human -DTXSID3020419 Css NA 0.06222 mg/L PBTK NA 50% Human Human -DTXSID3020419 Css NA 0.3971 mg/L PBTK NA 95% Human Human -DTXSID3020419 Clint NA 252.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020419 Fup NA 0.076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020419 Vd NA 2.166 L/kg 1compartment NA NA Rat Human -DTXSID3020419 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020419 TK.Half.Life NA 1.117 hours 1compartment NA NA Rat Human -DTXSID3020419 Css NA 0.05019 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020419 Css NA 0.2753 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020419 Css NA 0.03318 mg/L PBTK NA 50% Rat Human -DTXSID3020419 Css NA 0.1782 mg/L PBTK NA 95% Rat Human -DTXSID3020463 Clint NA 3.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020463 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020463 Vd NA 0.9971 L/kg 1compartment NA NA Human Human +DTXSID3020384 Css NA 0.124 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020384 Css NA 0.5064 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020384 Css NA 0.1194 mg/L PBTK NA 50% Rat Human +DTXSID3020384 Css NA 0.486 mg/L PBTK NA 95% Rat Human +DTXSID3020463 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020463 Fup 0.809 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020463 Vd NA 0.9134 L/kg 1compartment NA NA Human Human DTXSID3020463 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020463 TK.Half.Life NA 1.371 hours 1compartment NA NA Human Human -DTXSID3020463 Css NA 0.1264 mg/L 3compartmentss NA 50% Human Human -DTXSID3020463 Css NA 1.075 mg/L 3compartmentss NA 95% Human Human -DTXSID3020463 Css NA 0.1096 mg/L PBTK NA 50% Human Human -DTXSID3020463 Css NA 0.766 mg/L PBTK NA 95% Human Human -DTXSID3020463 Clint NA 3.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020463 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020463 Vd NA 1.018 L/kg 1compartment NA NA Rat Human +DTXSID3020463 TK.Half.Life NA 7.34 hours 1compartment NA NA Human Human +DTXSID3020463 Css NA 0.8148 mg/L 3compartmentss NA 50% Human Human +DTXSID3020463 Css NA 5.032 mg/L 3compartmentss NA 95% Human Human +DTXSID3020463 Css NA 0.6917 mg/L PBTK NA 50% Human Human +DTXSID3020463 Css NA 3.267 mg/L PBTK NA 95% Human Human +DTXSID3020463 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020463 Fup 0.809 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020463 Vd NA 0.9261 L/kg 1compartment NA NA Rat Human DTXSID3020463 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020463 TK.Half.Life NA 0.7337 hours 1compartment NA NA Rat Human -DTXSID3020463 Css NA 0.05596 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020463 Css NA 0.3857 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020463 Css NA 0.04847 mg/L PBTK NA 50% Rat Human -DTXSID3020463 Css NA 0.2452 mg/L PBTK NA 95% Rat Human +DTXSID3020463 TK.Half.Life NA 2.527 hours 1compartment NA NA Rat Human +DTXSID3020463 Css NA 0.01534 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020463 Css NA 0.1156 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020463 Css NA 0.01256 mg/L PBTK NA 50% Rat Human +DTXSID3020463 Css NA 0.07532 mg/L PBTK NA 95% Rat Human DTXSID3020465 Clint 39.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3020465 Fup 0.00935 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3020465 Vd NA 3.634 L/kg 1compartment NA NA Human Human DTXSID3020465 Days.Css NA 6 Days PBTK NA NA Human Human DTXSID3020465 TK.Half.Life NA 45.69 hours 1compartment NA NA Human Human -DTXSID3020465 Css NA 0.9236 mg/L 3compartmentss NA 50% Human Human -DTXSID3020465 Css NA 6.226 mg/L 3compartmentss NA 95% Human Human -DTXSID3020465 Css NA 1.026 mg/L PBTK NA 50% Human Human -DTXSID3020465 Css NA 6.16 mg/L PBTK NA 95% Human Human +DTXSID3020465 Css NA 0.8966 mg/L 3compartmentss NA 50% Human Human +DTXSID3020465 Css NA 6.175 mg/L 3compartmentss NA 95% Human Human +DTXSID3020465 Css NA 1.002 mg/L PBTK NA 50% Human Human +DTXSID3020465 Css NA 6.09 mg/L PBTK NA 95% Human Human DTXSID3020465 Clint 54.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID3020465 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID3020465 Css NA 0.4434 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3020465 Css NA 2.521 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3020469 Clint NA 9.962 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020469 Fup NA 0.2471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020469 Vd NA 1.611 L/kg 1compartment NA NA Human Human +DTXSID3020465 Css NA 0.1509 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3020465 Css NA 0.9746 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3020469 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020469 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020469 Vd NA 1.187 L/kg 1compartment NA NA Human Human DTXSID3020469 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020469 TK.Half.Life NA 4.085 hours 1compartment NA NA Human Human -DTXSID3020469 Css NA 0.2211 mg/L 3compartmentss NA 50% Human Human -DTXSID3020469 Css NA 1.338 mg/L 3compartmentss NA 95% Human Human -DTXSID3020469 Css NA 0.1636 mg/L PBTK NA 50% Human Human -DTXSID3020469 Css NA 0.935 mg/L PBTK NA 95% Human Human -DTXSID3020469 Clint NA 9.962 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020469 Fup NA 0.2471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020469 Vd NA 1.277 L/kg 1compartment NA NA Rat Human +DTXSID3020469 TK.Half.Life NA 2.219 hours 1compartment NA NA Human Human +DTXSID3020469 Css NA 0.1343 mg/L 3compartmentss NA 50% Human Human +DTXSID3020469 Css NA 0.9244 mg/L 3compartmentss NA 95% Human Human +DTXSID3020469 Css NA 0.09368 mg/L PBTK NA 50% Human Human +DTXSID3020469 Css NA 0.6124 mg/L PBTK NA 95% Human Human +DTXSID3020469 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020469 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020469 Vd NA 0.9489 L/kg 1compartment NA NA Rat Human DTXSID3020469 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020469 TK.Half.Life NA 1.589 hours 1compartment NA NA Rat Human -DTXSID3020469 Css NA 0.1172 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020469 Css NA 0.5338 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020469 Css NA 0.08324 mg/L PBTK NA 50% Rat Human -DTXSID3020469 Css NA 0.3454 mg/L PBTK NA 95% Rat Human -DTXSID3020540 Clint NA 41.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020540 Fup NA 0.0501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020540 Vd NA 1.826 L/kg 1compartment NA NA Human Human +DTXSID3020469 TK.Half.Life NA 0.9324 hours 1compartment NA NA Rat Human +DTXSID3020469 Css NA 0.01706 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020469 Css NA 0.09033 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020469 Css NA 0.01166 mg/L PBTK NA 50% Rat Human +DTXSID3020469 Css NA 0.05854 mg/L PBTK NA 95% Rat Human +DTXSID3020540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020540 Fup 0.0231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020540 Vd NA 1.318 L/kg 1compartment NA NA Human Human DTXSID3020540 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020540 TK.Half.Life NA 5.631 hours 1compartment NA NA Human Human -DTXSID3020540 Css NA 0.364 mg/L 3compartmentss NA 50% Human Human -DTXSID3020540 Css NA 2.795 mg/L 3compartmentss NA 95% Human Human -DTXSID3020540 Css NA 0.2355 mg/L PBTK NA 50% Human Human -DTXSID3020540 Css NA 1.74 mg/L PBTK NA 95% Human Human -DTXSID3020540 Clint NA 41.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020540 Fup NA 0.0501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020540 Vd NA 1.369 L/kg 1compartment NA NA Rat Human +DTXSID3020540 TK.Half.Life NA 10.68 hours 1compartment NA NA Human Human +DTXSID3020540 Css NA 1.253 mg/L 3compartmentss NA 50% Human Human +DTXSID3020540 Css NA 11.85 mg/L 3compartmentss NA 95% Human Human +DTXSID3020540 Css NA 0.7848 mg/L PBTK NA 50% Human Human +DTXSID3020540 Css NA 7.007 mg/L PBTK NA 95% Human Human +DTXSID3020540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020540 Fup 0.0231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020540 Vd NA 0.9799 L/kg 1compartment NA NA Rat Human DTXSID3020540 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020540 TK.Half.Life NA 1.959 hours 1compartment NA NA Rat Human -DTXSID3020540 Css NA 0.2047 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020540 Css NA 1.247 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020540 Css NA 0.1251 mg/L PBTK NA 50% Rat Human -DTXSID3020540 Css NA 0.7363 mg/L PBTK NA 95% Rat Human +DTXSID3020540 TK.Half.Life NA 4.329 hours 1compartment NA NA Rat Human +DTXSID3020540 Css NA 0.1618 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020540 Css NA 1.237 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020540 Css NA 0.0977 mg/L PBTK NA 50% Rat Human +DTXSID3020540 Css NA 0.7128 mg/L PBTK NA 95% Rat Human DTXSID3020546 Clint NA 0.8646 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020546 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020546 Vd NA 0.9872 L/kg 1compartment NA NA Human Human DTXSID3020546 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020546 TK.Half.Life NA 2.833 hours 1compartment NA NA Human Human -DTXSID3020546 Css NA 0.3316 mg/L 3compartmentss NA 50% Human Human -DTXSID3020546 Css NA 2.183 mg/L 3compartmentss NA 95% Human Human -DTXSID3020546 Css NA 0.2902 mg/L PBTK NA 50% Human Human -DTXSID3020546 Css NA 1.475 mg/L PBTK NA 95% Human Human +DTXSID3020546 Css NA 0.2736 mg/L 3compartmentss NA 50% Human Human +DTXSID3020546 Css NA 1.842 mg/L 3compartmentss NA 95% Human Human +DTXSID3020546 Css NA 0.2408 mg/L PBTK NA 50% Human Human +DTXSID3020546 Css NA 1.266 mg/L PBTK NA 95% Human Human DTXSID3020546 Clint NA 0.8646 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020546 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020546 Vd NA 0.9982 L/kg 1compartment NA NA Rat Human DTXSID3020546 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020546 TK.Half.Life NA 1.341 hours 1compartment NA NA Rat Human -DTXSID3020546 Css NA 0.1187 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020546 Css NA 0.7905 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020546 Css NA 0.1034 mg/L PBTK NA 50% Rat Human -DTXSID3020546 Css NA 0.4831 mg/L PBTK NA 95% Rat Human +DTXSID3020546 Css NA 0.007004 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020546 Css NA 0.06176 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020546 Css NA 0.006078 mg/L PBTK NA 50% Rat Human +DTXSID3020546 Css NA 0.04221 mg/L PBTK NA 95% Rat Human +DTXSID3020548 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020548 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020548 Vd NA 0.8816 L/kg 1compartment NA NA Human Human +DTXSID3020548 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3020548 TK.Half.Life NA 23.18 hours 1compartment NA NA Human Human +DTXSID3020548 Css NA 2.792 mg/L 3compartmentss NA 50% Human Human +DTXSID3020548 Css NA 10.94 mg/L 3compartmentss NA 95% Human Human +DTXSID3020548 Css NA 2.07 mg/L PBTK NA 50% Human Human +DTXSID3020548 Css NA 7.077 mg/L PBTK NA 95% Human Human +DTXSID3020548 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020548 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020548 Vd NA 0.8588 L/kg 1compartment NA NA Rat Human +DTXSID3020548 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3020548 TK.Half.Life NA 7.697 hours 1compartment NA NA Rat Human +DTXSID3020548 Css NA 0.179 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020548 Css NA 0.6 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020548 Css NA 0.1319 mg/L PBTK NA 50% Rat Human +DTXSID3020548 Css NA 0.3731 mg/L PBTK NA 95% Rat Human DTXSID3020598 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020598 Fup NA 0.9172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020598 Vd NA 0.7865 L/kg 1compartment NA NA Human Human +DTXSID3020598 Vd NA 0.8879 L/kg 1compartment NA NA Human Human DTXSID3020598 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020598 TK.Half.Life NA 5.554 hours 1compartment NA NA Human Human -DTXSID3020598 Css NA 0.8738 mg/L 3compartmentss NA 50% Human Human -DTXSID3020598 Css NA 3.292 mg/L 3compartmentss NA 95% Human Human -DTXSID3020598 Css NA 0.7344 mg/L PBTK NA 50% Human Human -DTXSID3020598 Css NA 2.287 mg/L PBTK NA 95% Human Human +DTXSID3020598 TK.Half.Life NA 6.301 hours 1compartment NA NA Human Human +DTXSID3020598 Css NA 0.7195 mg/L 3compartmentss NA 50% Human Human +DTXSID3020598 Css NA 2.789 mg/L 3compartmentss NA 95% Human Human +DTXSID3020598 Css NA 0.6207 mg/L PBTK NA 50% Human Human +DTXSID3020598 Css NA 1.974 mg/L PBTK NA 95% Human Human DTXSID3020598 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020598 Fup NA 0.9172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020598 Vd NA 0.8153 L/kg 1compartment NA NA Rat Human +DTXSID3020598 Vd NA 0.9015 L/kg 1compartment NA NA Rat Human DTXSID3020598 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020598 TK.Half.Life NA 1.961 hours 1compartment NA NA Rat Human -DTXSID3020598 Css NA 0.2232 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020598 Css NA 0.7867 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020598 Css NA 0.1834 mg/L PBTK NA 50% Rat Human -DTXSID3020598 Css NA 0.5053 mg/L PBTK NA 95% Rat Human +DTXSID3020598 TK.Half.Life NA 2.17 hours 1compartment NA NA Rat Human +DTXSID3020598 Css NA 0.01302 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020598 Css NA 0.07401 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020598 Css NA 0.01097 mg/L PBTK NA 50% Rat Human +DTXSID3020598 Css NA 0.05252 mg/L PBTK NA 95% Rat Human DTXSID3020621 Clint 0.766 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human -DTXSID3020621 Fup NA 0.008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020621 Vd NA 4.231 L/kg 1compartment NA NA Human Human +DTXSID3020621 Fup 0.00186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020621 Vd NA 4.078 L/kg 1compartment NA NA Human Human DTXSID3020621 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID3020621 TK.Half.Life NA 3497 hours 1compartment NA NA Human Human -DTXSID3020621 Css NA 89.83 mg/L 3compartmentss NA 50% Human Human -DTXSID3020621 Css NA 482.8 mg/L 3compartmentss NA 95% Human Human -DTXSID3020621 Css NA 68.37 mg/L PBTK NA 50% Human Human -DTXSID3020621 Css NA 358.7 mg/L PBTK NA 95% Human Human +DTXSID3020621 TK.Half.Life NA 3558 hours 1compartment NA NA Human Human +DTXSID3020621 Css NA 94.44 mg/L 3compartmentss NA 50% Human Human +DTXSID3020621 Css NA 517.8 mg/L 3compartmentss NA 95% Human Human +DTXSID3020621 Css NA 71.05 mg/L PBTK NA 50% Human Human +DTXSID3020621 Css NA 386.5 mg/L PBTK NA 95% Human Human DTXSID3020621 Clint 0.766 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human -DTXSID3020621 Fup NA 0.008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020621 Vd NA 3.208 L/kg 1compartment NA NA Rat Human -DTXSID3020621 Days.Css NA 496 Days PBTK NA NA Rat Human -DTXSID3020621 TK.Half.Life NA 460 hours 1compartment NA NA Rat Human -DTXSID3020621 Css NA 49.74 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020621 Css NA 192 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020621 Css NA 36.48 mg/L PBTK NA 50% Rat Human -DTXSID3020621 Css NA 141.4 mg/L PBTK NA 95% Rat Human +DTXSID3020621 Fup 0.00186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020621 Vd NA 3.087 L/kg 1compartment NA NA Rat Human +DTXSID3020621 Days.Css NA 505 Days PBTK NA NA Rat Human +DTXSID3020621 TK.Half.Life NA 540.3 hours 1compartment NA NA Rat Human +DTXSID3020621 Css NA 12.27 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020621 Css NA 48.66 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020621 Css NA 9.114 mg/L PBTK NA 50% Rat Human +DTXSID3020621 Css NA 37.47 mg/L PBTK NA 95% Rat Human DTXSID3020625 Clint 4.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3020625 Fup 0.095 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3020625 Vd NA 1.751 L/kg 1compartment NA NA Human Human DTXSID3020625 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID3020625 TK.Half.Life NA 19.8 hours 1compartment NA NA Human Human -DTXSID3020625 Css NA 1.435 mg/L 3compartmentss NA 50% Human Human -DTXSID3020625 Css NA 8.079 mg/L 3compartmentss NA 95% Human Human -DTXSID3020625 Css NA 0.8318 mg/L PBTK NA 50% Human Human -DTXSID3020625 Css NA 4.68 mg/L PBTK NA 95% Human Human +DTXSID3020625 Css NA 1.844 mg/L 3compartmentss NA 50% Human Human +DTXSID3020625 Css NA 10.14 mg/L 3compartmentss NA 95% Human Human +DTXSID3020625 Css NA 1.031 mg/L PBTK NA 50% Human Human +DTXSID3020625 Css NA 5.676 mg/L PBTK NA 95% Human Human DTXSID3020625 Clint 4.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3020625 Fup 0.095 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3020625 Vd NA 1.328 L/kg 1compartment NA NA Rat Human DTXSID3020625 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020625 TK.Half.Life NA 6.756 hours 1compartment NA NA Rat Human -DTXSID3020625 Css NA 0.9545 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020625 Css NA 3.778 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020625 Css NA 0.5155 mg/L PBTK NA 50% Rat Human -DTXSID3020625 Css NA 2.04 mg/L PBTK NA 95% Rat Human +DTXSID3020625 Css NA 0.2088 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020625 Css NA 0.8356 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020625 Css NA 0.121 mg/L PBTK NA 50% Rat Human +DTXSID3020625 Css NA 0.4847 mg/L PBTK NA 95% Rat Human DTXSID3020627 Clint 1.832 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020627 Fup 0.7109 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020627 Vd NA 0.8952 L/kg 1compartment NA NA Human Human DTXSID3020627 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020627 TK.Half.Life NA 2.3 hours 1compartment NA NA Human Human -DTXSID3020627 Css NA 0.2053 mg/L 3compartmentss NA 50% Human Human -DTXSID3020627 Css NA 1.648 mg/L 3compartmentss NA 95% Human Human -DTXSID3020627 Css NA 0.2026 mg/L PBTK NA 50% Human Human -DTXSID3020627 Css NA 1.182 mg/L PBTK NA 95% Human Human +DTXSID3020627 Css NA 0.2066 mg/L 3compartmentss NA 50% Human Human +DTXSID3020627 Css NA 1.167 mg/L 3compartmentss NA 95% Human Human +DTXSID3020627 Css NA 0.2179 mg/L PBTK NA 50% Human Human +DTXSID3020627 Css NA 1.235 mg/L PBTK NA 95% Human Human DTXSID3020627 Clint 1.832 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3020627 Fup 0.7109 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3020627 Vd NA 0.878 L/kg 1compartment NA NA Rat Human DTXSID3020627 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020627 TK.Half.Life NA 1.171 hours 1compartment NA NA Rat Human -DTXSID3020627 Css NA 0.09403 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020627 Css NA 0.7573 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020627 Css NA 0.09318 mg/L PBTK NA 50% Rat Human -DTXSID3020627 Css NA 0.4803 mg/L PBTK NA 95% Rat Human -DTXSID3020629 Clint NA 4.777 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020629 Fup NA 0.0144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020629 Vd NA 2.521 L/kg 1compartment NA NA Human Human -DTXSID3020629 Days.Css NA 31 Days PBTK NA NA Human Human -DTXSID3020629 TK.Half.Life NA 158.7 hours 1compartment NA NA Human Human -DTXSID3020629 Css NA 9.542 mg/L 3compartmentss NA 50% Human Human -DTXSID3020629 Css NA 58.39 mg/L 3compartmentss NA 95% Human Human -DTXSID3020629 Css NA 6.312 mg/L PBTK NA 50% Human Human -DTXSID3020629 Css NA 37.13 mg/L PBTK NA 95% Human Human -DTXSID3020629 Clint NA 4.777 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020629 Fup NA 0.0144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020629 Vd NA 1.879 L/kg 1compartment NA NA Rat Human -DTXSID3020629 Days.Css NA 16 Days PBTK NA NA Rat Human -DTXSID3020629 TK.Half.Life NA 36.69 hours 1compartment NA NA Rat Human -DTXSID3020629 Css NA 5.108 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020629 Css NA 25.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020629 Css NA 3.192 mg/L PBTK NA 50% Rat Human -DTXSID3020629 Css NA 15.2 mg/L PBTK NA 95% Rat Human -DTXSID3020671 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020671 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020671 Vd NA 1.389 L/kg 1compartment NA NA Human Human -DTXSID3020671 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID3020671 TK.Half.Life NA 66.65 hours 1compartment NA NA Human Human -DTXSID3020671 Css NA 7.588 mg/L 3compartmentss NA 50% Human Human -DTXSID3020671 Css NA 65.91 mg/L 3compartmentss NA 95% Human Human -DTXSID3020671 Css NA 5.162 mg/L PBTK NA 50% Human Human -DTXSID3020671 Css NA 40.52 mg/L PBTK NA 95% Human Human -DTXSID3020671 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020671 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020671 Vd NA 1.088 L/kg 1compartment NA NA Rat Human -DTXSID3020671 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID3020671 TK.Half.Life NA 30.27 hours 1compartment NA NA Rat Human -DTXSID3020671 Css NA 3.925 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020671 Css NA 27.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020671 Css NA 2.518 mg/L PBTK NA 50% Rat Human -DTXSID3020671 Css NA 15.45 mg/L PBTK NA 95% Rat Human +DTXSID3020627 Css NA 0.01937 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020627 Css NA 0.09804 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020627 Css NA 0.02126 mg/L PBTK NA 50% Rat Human +DTXSID3020627 Css NA 0.1076 mg/L PBTK NA 95% Rat Human +DTXSID3020629 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020629 Fup 0.0243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020629 Vd NA 2.752 L/kg 1compartment NA NA Human Human +DTXSID3020629 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID3020629 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human +DTXSID3020629 Css NA 5.99 mg/L 3compartmentss NA 50% Human Human +DTXSID3020629 Css NA 38.72 mg/L 3compartmentss NA 95% Human Human +DTXSID3020629 Css NA 4.042 mg/L PBTK NA 50% Human Human +DTXSID3020629 Css NA 24.88 mg/L PBTK NA 95% Human Human +DTXSID3020629 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020629 Fup 0.0243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020629 Vd NA 2.058 L/kg 1compartment NA NA Rat Human +DTXSID3020629 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID3020629 TK.Half.Life NA 23.59 hours 1compartment NA NA Rat Human +DTXSID3020629 Css NA 0.759 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020629 Css NA 3.798 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020629 Css NA 0.5042 mg/L PBTK NA 50% Rat Human +DTXSID3020629 Css NA 2.44 mg/L PBTK NA 95% Rat Human +DTXSID3020671 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020671 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020671 Vd NA 0.2701 L/kg 1compartment NA NA Human Human +DTXSID3020671 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3020671 TK.Half.Life NA 1.585 hours 1compartment NA NA Human Human +DTXSID3020671 Css NA 0.4527 mg/L 3compartmentss NA 50% Human Human +DTXSID3020671 Css NA 3.371 mg/L 3compartmentss NA 95% Human Human +DTXSID3020671 Css NA 0.2795 mg/L PBTK NA 50% Human Human +DTXSID3020671 Css NA 1.996 mg/L PBTK NA 95% Human Human +DTXSID3020671 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020671 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020671 Vd NA 0.2747 L/kg 1compartment NA NA Rat Human +DTXSID3020671 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3020671 TK.Half.Life NA 0.9835 hours 1compartment NA NA Rat Human +DTXSID3020671 Css NA 0.004676 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020671 Css NA 0.02944 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020671 Css NA 0.002706 mg/L PBTK NA 50% Rat Human +DTXSID3020671 Css NA 0.0165 mg/L PBTK NA 95% Rat Human DTXSID3020673 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3020673 Fup 0.0151 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3020673 Vd NA 1.277 L/kg 1compartment NA NA Human Human -DTXSID3020673 Days.Css NA 181 Days PBTK NA NA Human Human -DTXSID3020673 TK.Half.Life NA 710.4 hours 1compartment NA NA Human Human -DTXSID3020673 Css NA 67.88 mg/L 3compartmentss NA 50% Human Human -DTXSID3020673 Css NA 257.9 mg/L 3compartmentss NA 95% Human Human -DTXSID3020673 Css NA 43.26 mg/L PBTK NA 50% Human Human -DTXSID3020673 Css NA 153.6 mg/L PBTK NA 95% Human Human +DTXSID3020673 Vd NA 0.1661 L/kg 1compartment NA NA Human Human +DTXSID3020673 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID3020673 TK.Half.Life NA 71.16 hours 1compartment NA NA Human Human +DTXSID3020673 Css NA 46.45 mg/L 3compartmentss NA 50% Human Human +DTXSID3020673 Css NA 203.5 mg/L 3compartmentss NA 95% Human Human +DTXSID3020673 Css NA 27.11 mg/L PBTK NA 50% Human Human +DTXSID3020673 Css NA 117.8 mg/L PBTK NA 95% Human Human DTXSID3020673 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3020673 Fup 0.0151 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3020673 Vd NA 0.954 L/kg 1compartment NA NA Rat Human -DTXSID3020673 Days.Css NA 42 Days PBTK NA NA Rat Human -DTXSID3020673 TK.Half.Life NA 149.2 hours 1compartment NA NA Rat Human -DTXSID3020673 Css NA 18.79 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020673 Css NA 61.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020673 Css NA 11.33 mg/L PBTK NA 50% Rat Human -DTXSID3020673 Css NA 34.33 mg/L PBTK NA 95% Rat Human -DTXSID3020700 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020700 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020700 Vd NA 0.6711 L/kg 1compartment NA NA Human Human +DTXSID3020673 Vd NA 0.1654 L/kg 1compartment NA NA Rat Human +DTXSID3020673 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3020673 TK.Half.Life NA 24.15 hours 1compartment NA NA Rat Human +DTXSID3020673 Css NA 0.864 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020673 Css NA 5.419 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020673 Css NA 0.4754 mg/L PBTK NA 50% Rat Human +DTXSID3020673 Css NA 3.016 mg/L PBTK NA 95% Rat Human +DTXSID3020700 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020700 Fup 0.898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020700 Vd NA 0.7416 L/kg 1compartment NA NA Human Human DTXSID3020700 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020700 TK.Half.Life NA 4.343 hours 1compartment NA NA Human Human -DTXSID3020700 Css NA 0.8543 mg/L 3compartmentss NA 50% Human Human -DTXSID3020700 Css NA 5.584 mg/L 3compartmentss NA 95% Human Human -DTXSID3020700 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID3020700 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID3020700 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020700 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020700 Vd NA 0.7257 L/kg 1compartment NA NA Rat Human +DTXSID3020700 TK.Half.Life NA 5.348 hours 1compartment NA NA Human Human +DTXSID3020700 Css NA 0.8988 mg/L 3compartmentss NA 50% Human Human +DTXSID3020700 Css NA 5.007 mg/L 3compartmentss NA 95% Human Human +DTXSID3020700 Css NA 0.7436 mg/L PBTK NA 50% Human Human +DTXSID3020700 Css NA 3.275 mg/L PBTK NA 95% Human Human +DTXSID3020700 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020700 Fup 0.898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020700 Vd NA 0.7743 L/kg 1compartment NA NA Rat Human DTXSID3020700 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020700 TK.Half.Life NA 1.6 hours 1compartment NA NA Rat Human -DTXSID3020700 Css NA 0.2148 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020700 Css NA 1.342 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020700 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID3020700 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID3020704 Clint NA 56.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020704 Fup NA 0.2244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020704 Vd NA 0.6868 L/kg 1compartment NA NA Human Human +DTXSID3020700 TK.Half.Life NA 1.901 hours 1compartment NA NA Rat Human +DTXSID3020700 Css NA 0.05354 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020700 Css NA 0.2916 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020700 Css NA 0.04448 mg/L PBTK NA 50% Rat Human +DTXSID3020700 Css NA 0.1823 mg/L PBTK NA 95% Rat Human +DTXSID3020704 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020704 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020704 Vd NA 0.9285 L/kg 1compartment NA NA Human Human DTXSID3020704 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020704 TK.Half.Life NA 0.7473 hours 1compartment NA NA Human Human -DTXSID3020704 Css NA 0.03944 mg/L 3compartmentss NA 50% Human Human -DTXSID3020704 Css NA 0.2886 mg/L 3compartmentss NA 95% Human Human -DTXSID3020704 Css NA 0.02723 mg/L PBTK NA 50% Human Human -DTXSID3020704 Css NA 0.1867 mg/L PBTK NA 95% Human Human -DTXSID3020704 Clint NA 56.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020704 Fup NA 0.2244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020704 Vd NA 0.613 L/kg 1compartment NA NA Rat Human +DTXSID3020704 TK.Half.Life NA 1.467 hours 1compartment NA NA Human Human +DTXSID3020704 Css NA 0.1 mg/L 3compartmentss NA 50% Human Human +DTXSID3020704 Css NA 0.692 mg/L 3compartmentss NA 95% Human Human +DTXSID3020704 Css NA 0.07015 mg/L PBTK NA 50% Human Human +DTXSID3020704 Css NA 0.4596 mg/L PBTK NA 95% Human Human +DTXSID3020704 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020704 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020704 Vd NA 0.7815 L/kg 1compartment NA NA Rat Human DTXSID3020704 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020704 TK.Half.Life NA 0.3315 hours 1compartment NA NA Rat Human -DTXSID3020704 Css NA 0.02186 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020704 Css NA 0.1273 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020704 Css NA 0.01439 mg/L PBTK NA 50% Rat Human -DTXSID3020704 Css NA 0.07748 mg/L PBTK NA 95% Rat Human -DTXSID3020706 Clint NA 44.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020706 Fup NA 0.1618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020706 Vd NA 0.7148 L/kg 1compartment NA NA Human Human +DTXSID3020704 TK.Half.Life NA 0.6589 hours 1compartment NA NA Rat Human +DTXSID3020704 Css NA 0.01249 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020704 Css NA 0.06759 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020704 Css NA 0.008732 mg/L PBTK NA 50% Rat Human +DTXSID3020704 Css NA 0.04403 mg/L PBTK NA 95% Rat Human +DTXSID3020706 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020706 Fup 0.0726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020706 Vd NA 0.8157 L/kg 1compartment NA NA Human Human DTXSID3020706 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020706 TK.Half.Life NA 0.9653 hours 1compartment NA NA Human Human -DTXSID3020706 Css NA 0.07639 mg/L 3compartmentss NA 50% Human Human -DTXSID3020706 Css NA 0.5834 mg/L 3compartmentss NA 95% Human Human -DTXSID3020706 Css NA 0.05082 mg/L PBTK NA 50% Human Human -DTXSID3020706 Css NA 0.3667 mg/L PBTK NA 95% Human Human -DTXSID3020706 Clint NA 44.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020706 Fup NA 0.1618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020706 Vd NA 0.6109 L/kg 1compartment NA NA Rat Human +DTXSID3020706 TK.Half.Life NA 7.023 hours 1compartment NA NA Human Human +DTXSID3020706 Css NA 1.288 mg/L 3compartmentss NA 50% Human Human +DTXSID3020706 Css NA 8.514 mg/L 3compartmentss NA 95% Human Human +DTXSID3020706 Css NA 0.8096 mg/L PBTK NA 50% Human Human +DTXSID3020706 Css NA 5.157 mg/L PBTK NA 95% Human Human +DTXSID3020706 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020706 Fup 0.0726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020706 Vd NA 0.6437 L/kg 1compartment NA NA Rat Human DTXSID3020706 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020706 TK.Half.Life NA 0.4305 hours 1compartment NA NA Rat Human -DTXSID3020706 Css NA 0.0423 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020706 Css NA 0.2658 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020706 Css NA 0.02686 mg/L PBTK NA 50% Rat Human -DTXSID3020706 Css NA 0.1546 mg/L PBTK NA 95% Rat Human -DTXSID3020708 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020708 Fup NA 0.2666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020708 Vd NA 0.279 L/kg 1compartment NA NA Human Human +DTXSID3020706 TK.Half.Life NA 3.237 hours 1compartment NA NA Rat Human +DTXSID3020706 Css NA 0.1588 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020706 Css NA 0.7959 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020706 Css NA 0.09741 mg/L PBTK NA 50% Rat Human +DTXSID3020706 Css NA 0.4661 mg/L PBTK NA 95% Rat Human +DTXSID3020708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020708 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020708 Vd NA 0.3702 L/kg 1compartment NA NA Human Human DTXSID3020708 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020708 TK.Half.Life NA 6.769 hours 1compartment NA NA Human Human -DTXSID3020708 Css NA 3.077 mg/L 3compartmentss NA 50% Human Human -DTXSID3020708 Css NA 11.62 mg/L 3compartmentss NA 95% Human Human -DTXSID3020708 Css NA 1.976 mg/L PBTK NA 50% Human Human -DTXSID3020708 Css NA 6.96 mg/L PBTK NA 95% Human Human -DTXSID3020708 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020708 Fup NA 0.2666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020708 Vd NA 0.2869 L/kg 1compartment NA NA Rat Human +DTXSID3020708 TK.Half.Life NA 0.3896 hours 1compartment NA NA Human Human +DTXSID3020708 Css NA 0.04064 mg/L 3compartmentss NA 50% Human Human +DTXSID3020708 Css NA 0.3637 mg/L 3compartmentss NA 95% Human Human +DTXSID3020708 Css NA 0.02794 mg/L PBTK NA 50% Human Human +DTXSID3020708 Css NA 0.2308 mg/L PBTK NA 95% Human Human +DTXSID3020708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020708 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020708 Vd NA 0.3843 L/kg 1compartment NA NA Rat Human DTXSID3020708 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020708 TK.Half.Life NA 2.373 hours 1compartment NA NA Rat Human -DTXSID3020708 Css NA 0.8646 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020708 Css NA 2.639 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020708 Css NA 0.5224 mg/L PBTK NA 50% Rat Human -DTXSID3020708 Css NA 1.485 mg/L PBTK NA 95% Rat Human +DTXSID3020708 TK.Half.Life NA 0.2 hours 1compartment NA NA Rat Human +DTXSID3020708 Css NA 0.00504 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020708 Css NA 0.03717 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020708 Css NA 0.003462 mg/L PBTK NA 50% Rat Human +DTXSID3020708 Css NA 0.02283 mg/L PBTK NA 95% Rat Human DTXSID3020750 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020750 Fup NA 0.8905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020750 Vd NA 1.646 L/kg 1compartment NA NA Human Human +DTXSID3020750 Vd NA 1.597 L/kg 1compartment NA NA Human Human DTXSID3020750 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3020750 TK.Half.Life NA 14.15 hours 1compartment NA NA Human Human -DTXSID3020750 Css NA 0.879 mg/L 3compartmentss NA 50% Human Human -DTXSID3020750 Css NA 4.977 mg/L 3compartmentss NA 95% Human Human -DTXSID3020750 Css NA 0.832 mg/L PBTK NA 50% Human Human -DTXSID3020750 Css NA 3.455 mg/L PBTK NA 95% Human Human +DTXSID3020750 TK.Half.Life NA 13.49 hours 1compartment NA NA Human Human +DTXSID3020750 Css NA 0.736 mg/L 3compartmentss NA 50% Human Human +DTXSID3020750 Css NA 4.341 mg/L 3compartmentss NA 95% Human Human +DTXSID3020750 Css NA 0.6978 mg/L PBTK NA 50% Human Human +DTXSID3020750 Css NA 2.951 mg/L PBTK NA 95% Human Human DTXSID3020750 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020750 Fup NA 0.8905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020750 Vd NA 1.459 L/kg 1compartment NA NA Rat Human +DTXSID3020750 Vd NA 1.426 L/kg 1compartment NA NA Rat Human DTXSID3020750 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020750 TK.Half.Life NA 3.769 hours 1compartment NA NA Rat Human -DTXSID3020750 Css NA 0.2243 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020750 Css NA 1.401 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020750 Css NA 0.2086 mg/L PBTK NA 50% Rat Human -DTXSID3020750 Css NA 0.8853 mg/L PBTK NA 95% Rat Human -DTXSID3020756 Clint NA 1.435 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020756 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020756 Vd NA 0.8885 L/kg 1compartment NA NA Human Human +DTXSID3020750 TK.Half.Life NA 3.667 hours 1compartment NA NA Rat Human +DTXSID3020750 Css NA 0.01382 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020750 Css NA 0.1008 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020750 Css NA 0.01273 mg/L PBTK NA 50% Rat Human +DTXSID3020750 Css NA 0.07348 mg/L PBTK NA 95% Rat Human +DTXSID3020754 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020754 Fup 0.48 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3020754 Vd NA 1.084 L/kg 1compartment NA NA Human Human +DTXSID3020754 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3020754 TK.Half.Life NA 1.927 hours 1compartment NA NA Human Human +DTXSID3020754 Css NA 0.1322 mg/L 3compartmentss NA 50% Human Human +DTXSID3020754 Css NA 0.9504 mg/L 3compartmentss NA 95% Human Human +DTXSID3020754 Css NA 0.1072 mg/L PBTK NA 50% Human Human +DTXSID3020754 Css NA 0.6544 mg/L PBTK NA 95% Human Human +DTXSID3020754 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020754 Fup 0.48 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3020754 Vd NA 0.9902 L/kg 1compartment NA NA Rat Human +DTXSID3020754 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3020754 TK.Half.Life NA 0.9476 hours 1compartment NA NA Rat Human +DTXSID3020754 Css NA 0.01504 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020754 Css NA 0.09037 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020754 Css NA 0.01235 mg/L PBTK NA 50% Rat Human +DTXSID3020754 Css NA 0.05977 mg/L PBTK NA 95% Rat Human +DTXSID3020756 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020756 Fup 0.716 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020756 Vd NA 0.7248 L/kg 1compartment NA NA Human Human DTXSID3020756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020756 TK.Half.Life NA 1.953 hours 1compartment NA NA Human Human -DTXSID3020756 Css NA 0.2426 mg/L 3compartmentss NA 50% Human Human -DTXSID3020756 Css NA 1.763 mg/L 3compartmentss NA 95% Human Human -DTXSID3020756 Css NA 0.2091 mg/L PBTK NA 50% Human Human -DTXSID3020756 Css NA 1.207 mg/L PBTK NA 95% Human Human -DTXSID3020756 Clint NA 1.435 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020756 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020756 Vd NA 0.9109 L/kg 1compartment NA NA Rat Human +DTXSID3020756 TK.Half.Life NA 6.564 hours 1compartment NA NA Human Human +DTXSID3020756 Css NA 1.036 mg/L 3compartmentss NA 50% Human Human +DTXSID3020756 Css NA 6.799 mg/L 3compartmentss NA 95% Human Human +DTXSID3020756 Css NA 0.8431 mg/L PBTK NA 50% Human Human +DTXSID3020756 Css NA 4.278 mg/L PBTK NA 95% Human Human +DTXSID3020756 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020756 Fup 0.716 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020756 Vd NA 0.7416 L/kg 1compartment NA NA Rat Human DTXSID3020756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020756 TK.Half.Life NA 0.9972 hours 1compartment NA NA Rat Human -DTXSID3020756 Css NA 0.09648 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020756 Css NA 0.6347 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020756 Css NA 0.08226 mg/L PBTK NA 50% Rat Human -DTXSID3020756 Css NA 0.3918 mg/L PBTK NA 95% Rat Human +DTXSID3020756 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human +DTXSID3020756 Css NA 0.0619 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020756 Css NA 0.4089 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020756 Css NA 0.05061 mg/L PBTK NA 50% Rat Human +DTXSID3020756 Css NA 0.25 mg/L PBTK NA 95% Rat Human DTXSID3020835 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020835 Fup NA 0.9249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020835 Vd NA 0.6888 L/kg 1compartment NA NA Human Human +DTXSID3020835 Vd NA 0.6887 L/kg 1compartment NA NA Human Human DTXSID3020835 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020835 TK.Half.Life NA 4.82 hours 1compartment NA NA Human Human -DTXSID3020835 Css NA 0.8867 mg/L 3compartmentss NA 50% Human Human -DTXSID3020835 Css NA 3.311 mg/L 3compartmentss NA 95% Human Human -DTXSID3020835 Css NA 0.7245 mg/L PBTK NA 50% Human Human -DTXSID3020835 Css NA 2.253 mg/L PBTK NA 95% Human Human +DTXSID3020835 TK.Half.Life NA 4.817 hours 1compartment NA NA Human Human +DTXSID3020835 Css NA 0.7566 mg/L 3compartmentss NA 50% Human Human +DTXSID3020835 Css NA 2.822 mg/L 3compartmentss NA 95% Human Human +DTXSID3020835 Css NA 0.6214 mg/L PBTK NA 50% Human Human +DTXSID3020835 Css NA 1.973 mg/L PBTK NA 95% Human Human DTXSID3020835 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020835 Fup NA 0.9249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020835 Vd NA 0.7318 L/kg 1compartment NA NA Rat Human DTXSID3020835 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020835 TK.Half.Life NA 1.744 hours 1compartment NA NA Rat Human -DTXSID3020835 Css NA 0.2293 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020835 Css NA 0.8042 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020835 Css NA 0.1826 mg/L PBTK NA 50% Rat Human -DTXSID3020835 Css NA 0.5084 mg/L PBTK NA 95% Rat Human +DTXSID3020835 Css NA 0.01358 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020835 Css NA 0.0721 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020835 Css NA 0.01074 mg/L PBTK NA 50% Rat Human +DTXSID3020835 Css NA 0.05118 mg/L PBTK NA 95% Rat Human DTXSID3020881 Clint 4.538 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID3020881 Fup 0.9647 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID3020881 Vd NA 1.076 L/kg 1compartment NA NA Human Human +DTXSID3020881 Vd NA 1.144 L/kg 1compartment NA NA Human Human DTXSID3020881 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020881 TK.Half.Life NA 1.336 hours 1compartment NA NA Human Human -DTXSID3020881 Css NA 0.0891 mg/L 3compartmentss NA 50% Human Human -DTXSID3020881 Css NA 0.4353 mg/L 3compartmentss NA 95% Human Human -DTXSID3020881 Css NA 0.07815 mg/L PBTK NA 50% Human Human -DTXSID3020881 Css NA 0.3563 mg/L PBTK NA 95% Human Human +DTXSID3020881 TK.Half.Life NA 1.427 hours 1compartment NA NA Human Human +DTXSID3020881 Css NA 0.08486 mg/L 3compartmentss NA 50% Human Human +DTXSID3020881 Css NA 0.3915 mg/L 3compartmentss NA 95% Human Human +DTXSID3020881 Css NA 0.07575 mg/L PBTK NA 50% Human Human +DTXSID3020881 Css NA 0.3188 mg/L PBTK NA 95% Human Human DTXSID3020881 Clint 4.538 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID3020881 Fup 0.9647 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID3020881 Vd NA 1.018 L/kg 1compartment NA NA Rat Human +DTXSID3020881 Vd NA 1.068 L/kg 1compartment NA NA Rat Human DTXSID3020881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020881 TK.Half.Life NA 0.6508 hours 1compartment NA NA Rat Human -DTXSID3020881 Css NA 0.04236 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020881 Css NA 0.1444 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020881 Css NA 0.03706 mg/L PBTK NA 50% Rat Human -DTXSID3020881 Css NA 0.1136 mg/L PBTK NA 95% Rat Human +DTXSID3020881 TK.Half.Life NA 0.6822 hours 1compartment NA NA Rat Human +DTXSID3020881 Css NA 0.009254 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020881 Css NA 0.03083 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020881 Css NA 0.008505 mg/L PBTK NA 50% Rat Human +DTXSID3020881 Css NA 0.02622 mg/L PBTK NA 95% Rat Human +DTXSID3020885 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020885 Fup 0.883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020885 Vd NA 0.6758 L/kg 1compartment NA NA Human Human +DTXSID3020885 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3020885 TK.Half.Life NA 4.951 hours 1compartment NA NA Human Human +DTXSID3020885 Css NA 0.8144 mg/L 3compartmentss NA 50% Human Human +DTXSID3020885 Css NA 4.525 mg/L 3compartmentss NA 95% Human Human +DTXSID3020885 Css NA 0.6607 mg/L PBTK NA 50% Human Human +DTXSID3020885 Css NA 2.941 mg/L PBTK NA 95% Human Human +DTXSID3020885 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020885 Fup 0.883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020885 Vd NA 0.7176 L/kg 1compartment NA NA Rat Human +DTXSID3020885 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3020885 TK.Half.Life NA 1.792 hours 1compartment NA NA Rat Human +DTXSID3020885 Css NA 0.01528 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020885 Css NA 0.1094 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020885 Css NA 0.01178 mg/L PBTK NA 50% Rat Human +DTXSID3020885 Css NA 0.0701 mg/L PBTK NA 95% Rat Human DTXSID3020910 Clint 1.39 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID3020910 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3020910 Vd NA 0.8474 L/kg 1compartment NA NA Human Human DTXSID3020910 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020910 TK.Half.Life NA 1.895 hours 1compartment NA NA Human Human -DTXSID3020910 Css NA 0.2542 mg/L 3compartmentss NA 50% Human Human -DTXSID3020910 Css NA 1.908 mg/L 3compartmentss NA 95% Human Human -DTXSID3020910 Css NA 0.2156 mg/L PBTK NA 50% Human Human -DTXSID3020910 Css NA 1.315 mg/L PBTK NA 95% Human Human +DTXSID3020910 Css NA 0.2424 mg/L 3compartmentss NA 50% Human Human +DTXSID3020910 Css NA 1.748 mg/L 3compartmentss NA 95% Human Human +DTXSID3020910 Css NA 0.2066 mg/L PBTK NA 50% Human Human +DTXSID3020910 Css NA 1.2 mg/L PBTK NA 95% Human Human DTXSID3020910 Clint 1.39 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID3020910 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3020910 Vd NA 0.8755 L/kg 1compartment NA NA Rat Human DTXSID3020910 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020910 TK.Half.Life NA 0.9724 hours 1compartment NA NA Rat Human -DTXSID3020910 Css NA 0.09892 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020910 Css NA 0.6392 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020910 Css NA 0.0834 mg/L PBTK NA 50% Rat Human -DTXSID3020910 Css NA 0.3913 mg/L PBTK NA 95% Rat Human +DTXSID3020910 Css NA 0.02195 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020910 Css NA 0.1424 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020910 Css NA 0.0192 mg/L PBTK NA 50% Rat Human +DTXSID3020910 Css NA 0.0906 mg/L PBTK NA 95% Rat Human DTXSID3020912 Clint 1.1 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID3020912 Fup 0.749 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID3020912 Vd NA 1.009 L/kg 1compartment NA NA Human Human DTXSID3020912 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020912 TK.Half.Life NA 3.305 hours 1compartment NA NA Human Human -DTXSID3020912 Css NA 0.33 mg/L 3compartmentss NA 50% Human Human -DTXSID3020912 Css NA 2.307 mg/L 3compartmentss NA 95% Human Human -DTXSID3020912 Css NA 0.3063 mg/L PBTK NA 50% Human Human -DTXSID3020912 Css NA 1.563 mg/L PBTK NA 95% Human Human +DTXSID3020912 Css NA 0.3138 mg/L 3compartmentss NA 50% Human Human +DTXSID3020912 Css NA 2.334 mg/L 3compartmentss NA 95% Human Human +DTXSID3020912 Css NA 0.2944 mg/L PBTK NA 50% Human Human +DTXSID3020912 Css NA 1.592 mg/L PBTK NA 95% Human Human DTXSID3020912 Clint 1.1 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID3020912 Fup 0.749 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID3020912 Vd NA 0.5715 L/kg 1compartment NA NA Rat Human DTXSID3020912 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020912 TK.Half.Life NA 2.341 hours 1compartment NA NA Rat Human -DTXSID3020912 Css NA 0.3654 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020912 Css NA 1.346 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020912 Css NA 0.2576 mg/L PBTK NA 50% Rat Human -DTXSID3020912 Css NA 0.8142 mg/L PBTK NA 95% Rat Human -DTXSID3020914 Clint NA 4.551 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020914 Fup NA 0.2275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020914 Vd NA 0.5723 L/kg 1compartment NA NA Human Human -DTXSID3020914 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020914 TK.Half.Life NA 2.27 hours 1compartment NA NA Human Human -DTXSID3020914 Css NA 0.4207 mg/L 3compartmentss NA 50% Human Human -DTXSID3020914 Css NA 2.374 mg/L 3compartmentss NA 95% Human Human -DTXSID3020914 Css NA 0.287 mg/L PBTK NA 50% Human Human -DTXSID3020914 Css NA 1.507 mg/L PBTK NA 95% Human Human -DTXSID3020914 Clint NA 4.551 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020914 Fup NA 0.2275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020914 Vd NA 0.5319 L/kg 1compartment NA NA Rat Human -DTXSID3020914 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020914 TK.Half.Life NA 1.213 hours 1compartment NA NA Rat Human -DTXSID3020914 Css NA 0.2128 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020914 Css NA 0.8518 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020914 Css NA 0.1386 mg/L PBTK NA 50% Rat Human -DTXSID3020914 Css NA 0.5082 mg/L PBTK NA 95% Rat Human +DTXSID3020912 Css NA 0.08146 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020912 Css NA 0.3016 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020912 Css NA 0.0596 mg/L PBTK NA 50% Rat Human +DTXSID3020912 Css NA 0.1885 mg/L PBTK NA 95% Rat Human +DTXSID3020914 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020914 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020914 Vd NA 1.561 L/kg 1compartment NA NA Human Human +DTXSID3020914 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3020914 TK.Half.Life NA 40.18 hours 1compartment NA NA Human Human +DTXSID3020914 Css NA 2.652 mg/L 3compartmentss NA 50% Human Human +DTXSID3020914 Css NA 9.823 mg/L 3compartmentss NA 95% Human Human +DTXSID3020914 Css NA 2.055 mg/L PBTK NA 50% Human Human +DTXSID3020914 Css NA 6.589 mg/L PBTK NA 95% Human Human +DTXSID3020914 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020914 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020914 Vd NA 1.265 L/kg 1compartment NA NA Rat Human +DTXSID3020914 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3020914 TK.Half.Life NA 9.102 hours 1compartment NA NA Rat Human +DTXSID3020914 Css NA 0.1678 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020914 Css NA 0.5312 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020914 Css NA 0.1294 mg/L PBTK NA 50% Rat Human +DTXSID3020914 Css NA 0.3403 mg/L PBTK NA 95% Rat Human DTXSID3020916 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020916 Fup 0.6333 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020916 Vd NA 0.9942 L/kg 1compartment NA NA Human Human DTXSID3020916 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID3020916 TK.Half.Life NA 10.52 hours 1compartment NA NA Human Human -DTXSID3020916 Css NA 1.141 mg/L 3compartmentss NA 50% Human Human -DTXSID3020916 Css NA 7.598 mg/L 3compartmentss NA 95% Human Human -DTXSID3020916 Css NA 0.9665 mg/L PBTK NA 50% Human Human -DTXSID3020916 Css NA 4.885 mg/L PBTK NA 95% Human Human +DTXSID3020916 Css NA 1.115 mg/L 3compartmentss NA 50% Human Human +DTXSID3020916 Css NA 7.499 mg/L 3compartmentss NA 95% Human Human +DTXSID3020916 Css NA 0.9378 mg/L PBTK NA 50% Human Human +DTXSID3020916 Css NA 4.87 mg/L PBTK NA 95% Human Human DTXSID3020916 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3020916 Fup 0.6333 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3020916 Vd NA 0.9403 L/kg 1compartment NA NA Rat Human DTXSID3020916 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020916 TK.Half.Life NA 3.302 hours 1compartment NA NA Rat Human -DTXSID3020916 Css NA 0.2999 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020916 Css NA 1.814 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020916 Css NA 0.2452 mg/L PBTK NA 50% Rat Human -DTXSID3020916 Css NA 1.093 mg/L PBTK NA 95% Rat Human -DTXSID3020918 Clint NA 19.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020918 Fup NA 0.0138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020918 Vd NA 35 L/kg 1compartment NA NA Human Human -DTXSID3020918 Days.Css NA 286 Days PBTK NA NA Human Human -DTXSID3020918 TK.Half.Life NA 1159 hours 1compartment NA NA Human Human -DTXSID3020918 Css NA 0.7306 mg/L 3compartmentss NA 50% Human Human -DTXSID3020918 Css NA 4.411 mg/L 3compartmentss NA 95% Human Human -DTXSID3020918 Css NA 2.728 mg/L PBTK NA 50% Human Human -DTXSID3020918 Css NA 15.36 mg/L PBTK NA 95% Human Human -DTXSID3020918 Clint NA 19.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020918 Fup NA 0.0138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020918 Vd NA 29.09 L/kg 1compartment NA NA Rat Human -DTXSID3020918 Days.Css NA 175 Days PBTK NA NA Rat Human -DTXSID3020918 TK.Half.Life NA 167.1 hours 1compartment NA NA Rat Human -DTXSID3020918 Css NA 0.3786 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020918 Css NA 1.634 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020918 Css NA 1.484 mg/L PBTK NA 50% Rat Human -DTXSID3020918 Css NA 6.384 mg/L PBTK NA 95% Rat Human -DTXSID3020960 Clint NA 8.438 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020960 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020960 Vd NA 2.616 L/kg 1compartment NA NA Human Human -DTXSID3020960 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3020960 TK.Half.Life NA 44.75 hours 1compartment NA NA Human Human -DTXSID3020960 Css NA 2.303 mg/L 3compartmentss NA 50% Human Human -DTXSID3020960 Css NA 14.48 mg/L 3compartmentss NA 95% Human Human -DTXSID3020960 Css NA 1.566 mg/L PBTK NA 50% Human Human -DTXSID3020960 Css NA 9.392 mg/L PBTK NA 95% Human Human -DTXSID3020960 Clint NA 8.438 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020960 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020960 Vd NA 1.961 L/kg 1compartment NA NA Rat Human -DTXSID3020960 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3020960 TK.Half.Life NA 10.04 hours 1compartment NA NA Rat Human -DTXSID3020960 Css NA 1.261 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020960 Css NA 5.54 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020960 Css NA 0.8144 mg/L PBTK NA 50% Rat Human -DTXSID3020960 Css NA 3.456 mg/L PBTK NA 95% Rat Human -DTXSID3020962 Clint NA 22.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020962 Fup NA 0.5334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3020962 Vd NA 1.495 L/kg 1compartment NA NA Human Human +DTXSID3020916 Css NA 0.06751 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020916 Css NA 0.4216 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020916 Css NA 0.05725 mg/L PBTK NA 50% Rat Human +DTXSID3020916 Css NA 0.2624 mg/L PBTK NA 95% Rat Human +DTXSID3020918 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020918 Fup 0.00134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020918 Vd NA 1.986 L/kg 1compartment NA NA Human Human +DTXSID3020918 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID3020918 TK.Half.Life NA 76.3 hours 1compartment NA NA Human Human +DTXSID3020918 Css NA 6.103 mg/L 3compartmentss NA 50% Human Human +DTXSID3020918 Css NA 42.85 mg/L 3compartmentss NA 95% Human Human +DTXSID3020918 Css NA 3.859 mg/L PBTK NA 50% Human Human +DTXSID3020918 Css NA 26.47 mg/L PBTK NA 95% Human Human +DTXSID3020918 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020918 Fup 0.00134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020918 Vd NA 1.466 L/kg 1compartment NA NA Rat Human +DTXSID3020918 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID3020918 TK.Half.Life NA 24.54 hours 1compartment NA NA Rat Human +DTXSID3020918 Css NA 0.8056 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020918 Css NA 4.952 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020918 Css NA 0.4946 mg/L PBTK NA 50% Rat Human +DTXSID3020918 Css NA 2.972 mg/L PBTK NA 95% Rat Human +DTXSID3020960 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020960 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020960 Vd NA 2.252 L/kg 1compartment NA NA Human Human +DTXSID3020960 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3020960 TK.Half.Life NA 20.29 hours 1compartment NA NA Human Human +DTXSID3020960 Css NA 1.265 mg/L 3compartmentss NA 50% Human Human +DTXSID3020960 Css NA 10.13 mg/L 3compartmentss NA 95% Human Human +DTXSID3020960 Css NA 0.8266 mg/L PBTK NA 50% Human Human +DTXSID3020960 Css NA 6.293 mg/L PBTK NA 95% Human Human +DTXSID3020960 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020960 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020960 Vd NA 1.679 L/kg 1compartment NA NA Rat Human +DTXSID3020960 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3020960 TK.Half.Life NA 5.83 hours 1compartment NA NA Rat Human +DTXSID3020960 Css NA 0.163 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020960 Css NA 1.022 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020960 Css NA 0.1048 mg/L PBTK NA 50% Rat Human +DTXSID3020960 Css NA 0.6278 mg/L PBTK NA 95% Rat Human +DTXSID3020962 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020962 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3020962 Vd NA 1.059 L/kg 1compartment NA NA Human Human DTXSID3020962 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3020962 TK.Half.Life NA 1.445 hours 1compartment NA NA Human Human -DTXSID3020962 Css NA 0.04045 mg/L 3compartmentss NA 50% Human Human -DTXSID3020962 Css NA 0.374 mg/L 3compartmentss NA 95% Human Human -DTXSID3020962 Css NA 0.0341 mg/L PBTK NA 50% Human Human -DTXSID3020962 Css NA 0.2656 mg/L PBTK NA 95% Human Human -DTXSID3020962 Clint NA 22.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020962 Fup NA 0.5334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3020962 Vd NA 1.272 L/kg 1compartment NA NA Rat Human +DTXSID3020962 TK.Half.Life NA 1.443 hours 1compartment NA NA Human Human +DTXSID3020962 Css NA 0.07324 mg/L 3compartmentss NA 50% Human Human +DTXSID3020962 Css NA 0.5849 mg/L 3compartmentss NA 95% Human Human +DTXSID3020962 Css NA 0.05413 mg/L PBTK NA 50% Human Human +DTXSID3020962 Css NA 0.398 mg/L PBTK NA 95% Human Human +DTXSID3020962 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020962 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3020962 Vd NA 0.8951 L/kg 1compartment NA NA Rat Human DTXSID3020962 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3020962 TK.Half.Life NA 0.5899 hours 1compartment NA NA Rat Human -DTXSID3020962 Css NA 0.02154 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020962 Css NA 0.1602 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020962 Css NA 0.01764 mg/L PBTK NA 50% Rat Human -DTXSID3020962 Css NA 0.1109 mg/L PBTK NA 95% Rat Human +DTXSID3020962 TK.Half.Life NA 0.6313 hours 1compartment NA NA Rat Human +DTXSID3020962 Css NA 0.009306 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020962 Css NA 0.05225 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020962 Css NA 0.006839 mg/L PBTK NA 50% Rat Human +DTXSID3020962 Css NA 0.03466 mg/L PBTK NA 95% Rat Human DTXSID3020964 Clint 8.168 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020964 Fup 0.3844 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3020964 Vd NA 1.471 L/kg 1compartment NA NA Human Human DTXSID3020964 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3020964 TK.Half.Life NA 2.77 hours 1compartment NA NA Human Human -DTXSID3020964 Css NA 0.1397 mg/L 3compartmentss NA 50% Human Human -DTXSID3020964 Css NA 0.953 mg/L 3compartmentss NA 95% Human Human -DTXSID3020964 Css NA 0.1164 mg/L PBTK NA 50% Human Human -DTXSID3020964 Css NA 0.6948 mg/L PBTK NA 95% Human Human +DTXSID3020964 Css NA 0.1373 mg/L 3compartmentss NA 50% Human Human +DTXSID3020964 Css NA 0.9226 mg/L 3compartmentss NA 95% Human Human +DTXSID3020964 Css NA 0.1132 mg/L PBTK NA 50% Human Human +DTXSID3020964 Css NA 0.673 mg/L PBTK NA 95% Human Human DTXSID3020964 Clint 8.168 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3020964 Fup 0.3844 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3020964 Vd NA 1.254 L/kg 1compartment NA NA Rat Human DTXSID3020964 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020964 TK.Half.Life NA 1.217 hours 1compartment NA NA Rat Human -DTXSID3020964 Css NA 0.0712 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020964 Css NA 0.3727 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020964 Css NA 0.0577 mg/L PBTK NA 50% Rat Human -DTXSID3020964 Css NA 0.2551 mg/L PBTK NA 95% Rat Human +DTXSID3020964 Css NA 0.01584 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020964 Css NA 0.08098 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020964 Css NA 0.01321 mg/L PBTK NA 50% Rat Human +DTXSID3020964 Css NA 0.05762 mg/L PBTK NA 95% Rat Human DTXSID3020966 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020966 Fup NA 0.1482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3020966 Vd NA 0.4076 L/kg 1compartment NA NA Human Human DTXSID3020966 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID3020966 TK.Half.Life NA 17.79 hours 1compartment NA NA Human Human -DTXSID3020966 Css NA 6.062 mg/L 3compartmentss NA 50% Human Human -DTXSID3020966 Css NA 28.5 mg/L 3compartmentss NA 95% Human Human -DTXSID3020966 Css NA 3.982 mg/L PBTK NA 50% Human Human -DTXSID3020966 Css NA 16.95 mg/L PBTK NA 95% Human Human +DTXSID3020966 Css NA 5.864 mg/L 3compartmentss NA 50% Human Human +DTXSID3020966 Css NA 27.03 mg/L 3compartmentss NA 95% Human Human +DTXSID3020966 Css NA 3.854 mg/L PBTK NA 50% Human Human +DTXSID3020966 Css NA 16.35 mg/L PBTK NA 95% Human Human DTXSID3020966 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020966 Fup NA 0.1482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3020966 Vd NA 0.4048 L/kg 1compartment NA NA Rat Human DTXSID3020966 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3020966 TK.Half.Life NA 6.022 hours 1compartment NA NA Rat Human -DTXSID3020966 Css NA 1.71 mg/L 3compartmentss NA 50% Rat Human -DTXSID3020966 Css NA 6.628 mg/L 3compartmentss NA 95% Rat Human -DTXSID3020966 Css NA 1.058 mg/L PBTK NA 50% Rat Human -DTXSID3020966 Css NA 3.728 mg/L PBTK NA 95% Rat Human -DTXSID3021065 Clint NA 6.661 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021065 Fup NA 0.6594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021065 Vd NA 2.03 L/kg 1compartment NA NA Human Human +DTXSID3020966 Css NA 0.3834 mg/L 3compartmentss NA 50% Rat Human +DTXSID3020966 Css NA 1.502 mg/L 3compartmentss NA 95% Rat Human +DTXSID3020966 Css NA 0.2458 mg/L PBTK NA 50% Rat Human +DTXSID3020966 Css NA 0.8748 mg/L PBTK NA 95% Rat Human +DTXSID3021065 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021065 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021065 Vd NA 1.26 L/kg 1compartment NA NA Human Human DTXSID3021065 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021065 TK.Half.Life NA 3.375 hours 1compartment NA NA Human Human -DTXSID3021065 Css NA 0.1225 mg/L 3compartmentss NA 50% Human Human -DTXSID3021065 Css NA 1.025 mg/L 3compartmentss NA 95% Human Human -DTXSID3021065 Css NA 0.1078 mg/L PBTK NA 50% Human Human -DTXSID3021065 Css NA 0.7537 mg/L PBTK NA 95% Human Human -DTXSID3021065 Clint NA 6.661 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021065 Fup NA 0.6594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021065 Vd NA 1.673 L/kg 1compartment NA NA Rat Human +DTXSID3021065 TK.Half.Life NA 1.923 hours 1compartment NA NA Human Human +DTXSID3021065 Css NA 0.0934 mg/L 3compartmentss NA 50% Human Human +DTXSID3021065 Css NA 0.6702 mg/L 3compartmentss NA 95% Human Human +DTXSID3021065 Css NA 0.06766 mg/L PBTK NA 50% Human Human +DTXSID3021065 Css NA 0.444 mg/L PBTK NA 95% Human Human +DTXSID3021065 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021065 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021065 Vd NA 1.025 L/kg 1compartment NA NA Rat Human DTXSID3021065 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021065 TK.Half.Life NA 1.24 hours 1compartment NA NA Rat Human -DTXSID3021065 Css NA 0.06098 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021065 Css NA 0.4038 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021065 Css NA 0.05295 mg/L PBTK NA 50% Rat Human -DTXSID3021065 Css NA 0.2769 mg/L PBTK NA 95% Rat Human -DTXSID3021069 Clint NA 25.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021069 Fup NA 0.1298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021069 Vd NA 1.877 L/kg 1compartment NA NA Human Human +DTXSID3021065 TK.Half.Life NA 0.7998 hours 1compartment NA NA Rat Human +DTXSID3021065 Css NA 0.01168 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021065 Css NA 0.06139 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021065 Css NA 0.008486 mg/L PBTK NA 50% Rat Human +DTXSID3021065 Css NA 0.04233 mg/L PBTK NA 95% Rat Human +DTXSID3021069 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021069 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021069 Vd NA 1.637 L/kg 1compartment NA NA Human Human DTXSID3021069 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021069 TK.Half.Life NA 4.39 hours 1compartment NA NA Human Human -DTXSID3021069 Css NA 0.227 mg/L 3compartmentss NA 50% Human Human -DTXSID3021069 Css NA 1.65 mg/L 3compartmentss NA 95% Human Human -DTXSID3021069 Css NA 0.1552 mg/L PBTK NA 50% Human Human -DTXSID3021069 Css NA 1.076 mg/L PBTK NA 95% Human Human -DTXSID3021069 Clint NA 25.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021069 Fup NA 0.1298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021069 Vd NA 1.434 L/kg 1compartment NA NA Rat Human +DTXSID3021069 TK.Half.Life NA 4.421 hours 1compartment NA NA Human Human +DTXSID3021069 Css NA 0.2778 mg/L 3compartmentss NA 50% Human Human +DTXSID3021069 Css NA 2.131 mg/L 3compartmentss NA 95% Human Human +DTXSID3021069 Css NA 0.1856 mg/L PBTK NA 50% Human Human +DTXSID3021069 Css NA 1.365 mg/L PBTK NA 95% Human Human +DTXSID3021069 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021069 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021069 Vd NA 1.253 L/kg 1compartment NA NA Rat Human DTXSID3021069 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021069 TK.Half.Life NA 1.533 hours 1compartment NA NA Rat Human -DTXSID3021069 Css NA 0.1255 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021069 Css NA 0.702 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021069 Css NA 0.08202 mg/L PBTK NA 50% Rat Human -DTXSID3021069 Css NA 0.4294 mg/L PBTK NA 95% Rat Human -DTXSID3021140 Clint NA 28.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021140 Fup NA 0.969 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021140 Vd NA 0.9698 L/kg 1compartment NA NA Human Human +DTXSID3021069 TK.Half.Life NA 1.653 hours 1compartment NA NA Rat Human +DTXSID3021069 Css NA 0.03576 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021069 Css NA 0.2067 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021069 Css NA 0.02357 mg/L PBTK NA 50% Rat Human +DTXSID3021069 Css NA 0.1282 mg/L PBTK NA 95% Rat Human +DTXSID30210695 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30210695 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30210695 Vd NA 1.583 L/kg 1compartment NA NA Human Human +DTXSID30210695 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID30210695 TK.Half.Life NA 18.51 hours 1compartment NA NA Human Human +DTXSID30210695 Css NA 1.832 mg/L 3compartmentss NA 50% Human Human +DTXSID30210695 Css NA 16.58 mg/L 3compartmentss NA 95% Human Human +DTXSID30210695 Css NA 1.139 mg/L PBTK NA 50% Human Human +DTXSID30210695 Css NA 9.897 mg/L PBTK NA 95% Human Human +DTXSID30210695 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30210695 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30210695 Vd NA 1.171 L/kg 1compartment NA NA Rat Human +DTXSID30210695 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30210695 TK.Half.Life NA 6.938 hours 1compartment NA NA Rat Human +DTXSID30210695 Css NA 0.2425 mg/L 3compartmentss NA 50% Rat Human +DTXSID30210695 Css NA 1.714 mg/L 3compartmentss NA 95% Rat Human +DTXSID30210695 Css NA 0.1469 mg/L PBTK NA 50% Rat Human +DTXSID30210695 Css NA 0.9993 mg/L PBTK NA 95% Rat Human +DTXSID3021140 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021140 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021140 Vd NA 0.7196 L/kg 1compartment NA NA Human Human DTXSID3021140 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021140 TK.Half.Life NA 0.6353 hours 1compartment NA NA Human Human -DTXSID3021140 Css NA 0.01892 mg/L 3compartmentss NA 50% Human Human -DTXSID3021140 Css NA 0.1977 mg/L 3compartmentss NA 95% Human Human -DTXSID3021140 Css NA 0.01623 mg/L PBTK NA 50% Human Human -DTXSID3021140 Css NA 0.1459 mg/L PBTK NA 95% Human Human -DTXSID3021140 Clint NA 28.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021140 Fup NA 0.969 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021140 Vd NA 0.9749 L/kg 1compartment NA NA Rat Human +DTXSID3021140 TK.Half.Life NA 7.473 hours 1compartment NA NA Human Human +DTXSID3021140 Css NA 1.159 mg/L 3compartmentss NA 50% Human Human +DTXSID3021140 Css NA 7.914 mg/L 3compartmentss NA 95% Human Human +DTXSID3021140 Css NA 0.9304 mg/L PBTK NA 50% Human Human +DTXSID3021140 Css NA 4.853 mg/L PBTK NA 95% Human Human +DTXSID3021140 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021140 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021140 Vd NA 0.7262 L/kg 1compartment NA NA Rat Human DTXSID3021140 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021140 TK.Half.Life NA 0.2998 hours 1compartment NA NA Rat Human -DTXSID3021140 Css NA 0.009649 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021140 Css NA 0.08544 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021140 Css NA 0.00822 mg/L PBTK NA 50% Rat Human -DTXSID3021140 Css NA 0.0602 mg/L PBTK NA 95% Rat Human -DTXSID3021142 Clint NA 33.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021142 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021142 Vd NA 2.416 L/kg 1compartment NA NA Human Human -DTXSID3021142 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021142 TK.Half.Life NA 1.243 hours 1compartment NA NA Human Human -DTXSID3021142 Css NA 0.01212 mg/L 3compartmentss NA 50% Human Human -DTXSID3021142 Css NA 0.1714 mg/L 3compartmentss NA 95% Human Human -DTXSID3021142 Css NA 0.01298 mg/L PBTK NA 50% Human Human -DTXSID3021142 Css NA 0.1515 mg/L PBTK NA 95% Human Human -DTXSID3021142 Clint NA 33.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021142 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021142 Vd NA 2.46 L/kg 1compartment NA NA Rat Human +DTXSID3021140 TK.Half.Life NA 2.561 hours 1compartment NA NA Rat Human +DTXSID3021140 Css NA 0.07005 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021140 Css NA 0.4514 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021140 Css NA 0.0562 mg/L PBTK NA 50% Rat Human +DTXSID3021140 Css NA 0.275 mg/L PBTK NA 95% Rat Human +DTXSID3021142 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021142 Fup 0.701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021142 Vd NA 2.871 L/kg 1compartment NA NA Human Human +DTXSID3021142 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3021142 TK.Half.Life NA 26.54 hours 1compartment NA NA Human Human +DTXSID3021142 Css NA 0.7445 mg/L 3compartmentss NA 50% Human Human +DTXSID3021142 Css NA 6.241 mg/L 3compartmentss NA 95% Human Human +DTXSID3021142 Css NA 0.8611 mg/L PBTK NA 50% Human Human +DTXSID3021142 Css NA 4.477 mg/L PBTK NA 95% Human Human +DTXSID3021142 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021142 Fup 0.701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021142 Vd NA 2.918 L/kg 1compartment NA NA Rat Human DTXSID3021142 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021142 TK.Half.Life NA 0.6027 hours 1compartment NA NA Rat Human -DTXSID3021142 Css NA 0.006024 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021142 Css NA 0.06956 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021142 Css NA 0.006528 mg/L PBTK NA 50% Rat Human -DTXSID3021142 Css NA 0.05932 mg/L PBTK NA 95% Rat Human -DTXSID3021144 Clint NA 10.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021144 Fup NA 0.7392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021144 Vd NA 2.127 L/kg 1compartment NA NA Human Human +DTXSID3021142 TK.Half.Life NA 9.181 hours 1compartment NA NA Rat Human +DTXSID3021142 Css NA 0.04323 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021142 Css NA 0.3575 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021142 Css NA 0.05136 mg/L PBTK NA 50% Rat Human +DTXSID3021142 Css NA 0.2468 mg/L PBTK NA 95% Rat Human +DTXSID3021144 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021144 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021144 Vd NA 1.173 L/kg 1compartment NA NA Human Human DTXSID3021144 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021144 TK.Half.Life NA 1.932 hours 1compartment NA NA Human Human -DTXSID3021144 Css NA 0.0487 mg/L 3compartmentss NA 50% Human Human -DTXSID3021144 Css NA 0.4862 mg/L 3compartmentss NA 95% Human Human -DTXSID3021144 Css NA 0.04892 mg/L PBTK NA 50% Human Human -DTXSID3021144 Css NA 0.379 mg/L PBTK NA 95% Human Human -DTXSID3021144 Clint NA 10.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021144 Fup NA 0.7392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021144 Vd NA 2.136 L/kg 1compartment NA NA Rat Human +DTXSID3021144 TK.Half.Life NA 1.714 hours 1compartment NA NA Human Human +DTXSID3021144 Css NA 0.1054 mg/L 3compartmentss NA 50% Human Human +DTXSID3021144 Css NA 0.9774 mg/L 3compartmentss NA 95% Human Human +DTXSID3021144 Css NA 0.08916 mg/L PBTK NA 50% Human Human +DTXSID3021144 Css NA 0.6717 mg/L PBTK NA 95% Human Human +DTXSID3021144 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021144 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021144 Vd NA 1.19 L/kg 1compartment NA NA Rat Human DTXSID3021144 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021144 TK.Half.Life NA 1.022 hours 1compartment NA NA Rat Human -DTXSID3021144 Css NA 0.02364 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021144 Css NA 0.2194 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021144 Css NA 0.02382 mg/L PBTK NA 50% Rat Human -DTXSID3021144 Css NA 0.1549 mg/L PBTK NA 95% Rat Human -DTXSID3021148 Clint NA 16.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021148 Fup NA 0.672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021148 Vd NA 1.245 L/kg 1compartment NA NA Human Human +DTXSID3021144 TK.Half.Life NA 0.9491 hours 1compartment NA NA Rat Human +DTXSID3021144 Css NA 0.01184 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021144 Css NA 0.1 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021144 Css NA 0.01025 mg/L PBTK NA 50% Rat Human +DTXSID3021144 Css NA 0.06364 mg/L PBTK NA 95% Rat Human +DTXSID3021148 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021148 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021148 Vd NA 1.082 L/kg 1compartment NA NA Human Human DTXSID3021148 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021148 TK.Half.Life NA 1.128 hours 1compartment NA NA Human Human -DTXSID3021148 Css NA 0.04134 mg/L 3compartmentss NA 50% Human Human -DTXSID3021148 Css NA 0.4211 mg/L 3compartmentss NA 95% Human Human -DTXSID3021148 Css NA 0.03558 mg/L PBTK NA 50% Human Human -DTXSID3021148 Css NA 0.2984 mg/L PBTK NA 95% Human Human -DTXSID3021148 Clint NA 16.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021148 Fup NA 0.672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021148 Vd NA 1.128 L/kg 1compartment NA NA Rat Human +DTXSID3021148 TK.Half.Life NA 0.9789 hours 1compartment NA NA Human Human +DTXSID3021148 Css NA 0.03341 mg/L 3compartmentss NA 50% Human Human +DTXSID3021148 Css NA 0.3925 mg/L 3compartmentss NA 95% Human Human +DTXSID3021148 Css NA 0.02756 mg/L PBTK NA 50% Human Human +DTXSID3021148 Css NA 0.2769 mg/L PBTK NA 95% Human Human +DTXSID3021148 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021148 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021148 Vd NA 0.9901 L/kg 1compartment NA NA Rat Human DTXSID3021148 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021148 TK.Half.Life NA 0.5056 hours 1compartment NA NA Rat Human -DTXSID3021148 Css NA 0.02043 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021148 Css NA 0.1821 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021148 Css NA 0.0174 mg/L PBTK NA 50% Rat Human -DTXSID3021148 Css NA 0.1184 mg/L PBTK NA 95% Rat Human -DTXSID3021190 Clint NA 48.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021190 Fup NA 0.6261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021190 Vd NA 1.179 L/kg 1compartment NA NA Human Human +DTXSID3021148 TK.Half.Life NA 0.4421 hours 1compartment NA NA Rat Human +DTXSID3021148 Css NA 0.004068 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021148 Css NA 0.03899 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021148 Css NA 0.003443 mg/L PBTK NA 50% Rat Human +DTXSID3021148 Css NA 0.02591 mg/L PBTK NA 95% Rat Human +DTXSID3021190 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021190 Fup 0.702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021190 Vd NA 1.409 L/kg 1compartment NA NA Human Human DTXSID3021190 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021190 TK.Half.Life NA 0.8341 hours 1compartment NA NA Human Human -DTXSID3021190 Css NA 0.015 mg/L 3compartmentss NA 50% Human Human -DTXSID3021190 Css NA 0.1674 mg/L 3compartmentss NA 95% Human Human -DTXSID3021190 Css NA 0.01264 mg/L PBTK NA 50% Human Human -DTXSID3021190 Css NA 0.1184 mg/L PBTK NA 95% Human Human -DTXSID3021190 Clint NA 48.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021190 Fup NA 0.6261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021190 Vd NA 1.188 L/kg 1compartment NA NA Rat Human +DTXSID3021190 TK.Half.Life NA 1.804 hours 1compartment NA NA Human Human +DTXSID3021190 Css NA 0.08799 mg/L 3compartmentss NA 50% Human Human +DTXSID3021190 Css NA 0.842 mg/L 3compartmentss NA 95% Human Human +DTXSID3021190 Css NA 0.07924 mg/L PBTK NA 50% Human Human +DTXSID3021190 Css NA 0.6002 mg/L PBTK NA 95% Human Human +DTXSID3021190 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021190 Fup 0.702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021190 Vd NA 1.414 L/kg 1compartment NA NA Rat Human DTXSID3021190 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021190 TK.Half.Life NA 0.3943 hours 1compartment NA NA Rat Human -DTXSID3021190 Css NA 0.007591 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021190 Css NA 0.07765 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021190 Css NA 0.006432 mg/L PBTK NA 50% Rat Human -DTXSID3021190 Css NA 0.052 mg/L PBTK NA 95% Rat Human -DTXSID3021192 Clint NA 6.742 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021192 Fup NA 0.0976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021192 Vd NA 3.104 L/kg 1compartment NA NA Human Human -DTXSID3021192 Days.Css NA 31 Days PBTK NA NA Human Human -DTXSID3021192 TK.Half.Life NA 162.7 hours 1compartment NA NA Human Human -DTXSID3021192 Css NA 6.48 mg/L 3compartmentss NA 50% Human Human -DTXSID3021192 Css NA 38.07 mg/L 3compartmentss NA 95% Human Human -DTXSID3021192 Css NA 4.518 mg/L PBTK NA 50% Human Human -DTXSID3021192 Css NA 25.46 mg/L PBTK NA 95% Human Human -DTXSID3021192 Clint NA 6.742 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021192 Fup NA 0.0976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021192 Vd NA 2.328 L/kg 1compartment NA NA Rat Human -DTXSID3021192 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID3021192 TK.Half.Life NA 21.9 hours 1compartment NA NA Rat Human -DTXSID3021192 Css NA 3.566 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021192 Css NA 17.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021192 Css NA 2.377 mg/L PBTK NA 50% Rat Human -DTXSID3021192 Css NA 11.25 mg/L PBTK NA 95% Rat Human +DTXSID3021190 TK.Half.Life NA 0.9753 hours 1compartment NA NA Rat Human +DTXSID3021190 Css NA 0.00965 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021190 Css NA 0.0808 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021190 Css NA 0.008968 mg/L PBTK NA 50% Rat Human +DTXSID3021190 Css NA 0.05326 mg/L PBTK NA 95% Rat Human +DTXSID3021192 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021192 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021192 Vd NA 3.181 L/kg 1compartment NA NA Human Human +DTXSID3021192 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3021192 TK.Half.Life NA 15.05 hours 1compartment NA NA Human Human +DTXSID3021192 Css NA 0.4738 mg/L 3compartmentss NA 50% Human Human +DTXSID3021192 Css NA 3.019 mg/L 3compartmentss NA 95% Human Human +DTXSID3021192 Css NA 0.3478 mg/L PBTK NA 50% Human Human +DTXSID3021192 Css NA 2.147 mg/L PBTK NA 95% Human Human +DTXSID3021192 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021192 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021192 Vd NA 2.489 L/kg 1compartment NA NA Rat Human +DTXSID3021192 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3021192 TK.Half.Life NA 3.105 hours 1compartment NA NA Rat Human +DTXSID3021192 Css NA 0.06013 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021192 Css NA 0.3212 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021192 Css NA 0.04449 mg/L PBTK NA 50% Rat Human +DTXSID3021192 Css NA 0.2292 mg/L PBTK NA 95% Rat Human DTXSID3021196 Clint 14.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3021196 Fup 0.03651 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3021196 Vd NA 1.146 L/kg 1compartment NA NA Human Human DTXSID3021196 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3021196 TK.Half.Life NA 8.968 hours 1compartment NA NA Human Human -DTXSID3021196 Css NA 1.284 mg/L 3compartmentss NA 50% Human Human -DTXSID3021196 Css NA 10.2 mg/L 3compartmentss NA 95% Human Human -DTXSID3021196 Css NA 0.7969 mg/L PBTK NA 50% Human Human -DTXSID3021196 Css NA 6.192 mg/L PBTK NA 95% Human Human +DTXSID3021196 Css NA 1.25 mg/L 3compartmentss NA 50% Human Human +DTXSID3021196 Css NA 10.05 mg/L 3compartmentss NA 95% Human Human +DTXSID3021196 Css NA 0.7784 mg/L PBTK NA 50% Human Human +DTXSID3021196 Css NA 5.948 mg/L PBTK NA 95% Human Human DTXSID3021196 Clint 14.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3021196 Fup 0.03651 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3021196 Vd NA 0.8619 L/kg 1compartment NA NA Rat Human DTXSID3021196 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3021196 TK.Half.Life NA 3.809 hours 1compartment NA NA Rat Human -DTXSID3021196 Css NA 0.7106 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021196 Css NA 4.358 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021196 Css NA 0.4144 mg/L PBTK NA 50% Rat Human -DTXSID3021196 Css NA 2.445 mg/L PBTK NA 95% Rat Human -DTXSID3021198 Clint NA 128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021198 Fup NA 0.2148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021198 Vd NA 3.991 L/kg 1compartment NA NA Human Human -DTXSID3021198 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021198 TK.Half.Life NA 2.222 hours 1compartment NA NA Human Human -DTXSID3021198 Css NA 0.00809 mg/L 3compartmentss NA 50% Human Human -DTXSID3021198 Css NA 0.07077 mg/L 3compartmentss NA 95% Human Human -DTXSID3021198 Css NA 0.009616 mg/L PBTK NA 50% Human Human -DTXSID3021198 Css NA 0.06735 mg/L PBTK NA 95% Human Human -DTXSID3021198 Clint NA 128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021198 Fup NA 0.2148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021198 Vd NA 3.968 L/kg 1compartment NA NA Rat Human -DTXSID3021198 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021198 TK.Half.Life NA 1.04 hours 1compartment NA NA Rat Human -DTXSID3021198 Css NA 0.004323 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021198 Css NA 0.03037 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021198 Css NA 0.005118 mg/L PBTK NA 50% Rat Human -DTXSID3021198 Css NA 0.029 mg/L PBTK NA 95% Rat Human -DTXSID3021221 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021221 Fup NA 0.0877 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021221 Vd NA 0.253 L/kg 1compartment NA NA Human Human -DTXSID3021221 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3021221 TK.Half.Life NA 18.68 hours 1compartment NA NA Human Human -DTXSID3021221 Css NA 12 mg/L 3compartmentss NA 50% Human Human -DTXSID3021221 Css NA 53.44 mg/L 3compartmentss NA 95% Human Human -DTXSID3021221 Css NA 7.226 mg/L PBTK NA 50% Human Human -DTXSID3021221 Css NA 30.7 mg/L PBTK NA 95% Human Human -DTXSID3021221 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021221 Fup NA 0.0877 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021221 Vd NA 0.2476 L/kg 1compartment NA NA Rat Human +DTXSID3021196 Css NA 0.1632 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021196 Css NA 0.9835 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021196 Css NA 0.09802 mg/L PBTK NA 50% Rat Human +DTXSID3021196 Css NA 0.5757 mg/L PBTK NA 95% Rat Human +DTXSID3021198 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021198 Fup 0.428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021198 Vd NA 2.123 L/kg 1compartment NA NA Human Human +DTXSID3021198 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3021198 TK.Half.Life NA 32.11 hours 1compartment NA NA Human Human +DTXSID3021198 Css NA 1.219 mg/L 3compartmentss NA 50% Human Human +DTXSID3021198 Css NA 6.337 mg/L 3compartmentss NA 95% Human Human +DTXSID3021198 Css NA 1.219 mg/L PBTK NA 50% Human Human +DTXSID3021198 Css NA 4.657 mg/L PBTK NA 95% Human Human +DTXSID3021198 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021198 Fup 0.428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021198 Vd NA 2.129 L/kg 1compartment NA NA Rat Human +DTXSID3021198 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3021198 TK.Half.Life NA 10.96 hours 1compartment NA NA Rat Human +DTXSID3021198 Css NA 0.07527 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021198 Css NA 0.3567 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021198 Css NA 0.07666 mg/L PBTK NA 50% Rat Human +DTXSID3021198 Css NA 0.25 mg/L PBTK NA 95% Rat Human +DTXSID3021221 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021221 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021221 Vd NA 0.4876 L/kg 1compartment NA NA Human Human +DTXSID3021221 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3021221 TK.Half.Life NA 0.8781 hours 1compartment NA NA Human Human +DTXSID3021221 Css NA 0.1254 mg/L 3compartmentss NA 50% Human Human +DTXSID3021221 Css NA 0.8671 mg/L 3compartmentss NA 95% Human Human +DTXSID3021221 Css NA 0.08216 mg/L PBTK NA 50% Human Human +DTXSID3021221 Css NA 0.5404 mg/L PBTK NA 95% Human Human +DTXSID3021221 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021221 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021221 Vd NA 0.435 L/kg 1compartment NA NA Rat Human DTXSID3021221 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021221 TK.Half.Life NA 6.228 hours 1compartment NA NA Rat Human -DTXSID3021221 Css NA 3.404 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021221 Css NA 12.72 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021221 Css NA 1.921 mg/L PBTK NA 50% Rat Human -DTXSID3021221 Css NA 6.954 mg/L PBTK NA 95% Rat Human -DTXSID3021223 Clint NA 24.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021223 Fup NA 0.1578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021223 Vd NA 1.918 L/kg 1compartment NA NA Human Human +DTXSID3021221 TK.Half.Life NA 0.4357 hours 1compartment NA NA Rat Human +DTXSID3021221 Css NA 0.0162 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021221 Css NA 0.08548 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021221 Css NA 0.0104 mg/L PBTK NA 50% Rat Human +DTXSID3021221 Css NA 0.05319 mg/L PBTK NA 95% Rat Human +DTXSID3021223 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021223 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021223 Vd NA 2.937 L/kg 1compartment NA NA Human Human DTXSID3021223 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021223 TK.Half.Life NA 3.729 hours 1compartment NA NA Human Human -DTXSID3021223 Css NA 0.1596 mg/L 3compartmentss NA 50% Human Human -DTXSID3021223 Css NA 1.122 mg/L 3compartmentss NA 95% Human Human -DTXSID3021223 Css NA 0.1168 mg/L PBTK NA 50% Human Human -DTXSID3021223 Css NA 0.7599 mg/L PBTK NA 95% Human Human -DTXSID3021223 Clint NA 24.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021223 Fup NA 0.1578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021223 Vd NA 1.574 L/kg 1compartment NA NA Rat Human +DTXSID3021223 TK.Half.Life NA 11.17 hours 1compartment NA NA Human Human +DTXSID3021223 Css NA 0.3361 mg/L 3compartmentss NA 50% Human Human +DTXSID3021223 Css NA 1.848 mg/L 3compartmentss NA 95% Human Human +DTXSID3021223 Css NA 0.2792 mg/L PBTK NA 50% Human Human +DTXSID3021223 Css NA 1.422 mg/L PBTK NA 95% Human Human +DTXSID3021223 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021223 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021223 Vd NA 2.395 L/kg 1compartment NA NA Rat Human DTXSID3021223 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021223 TK.Half.Life NA 1.487 hours 1compartment NA NA Rat Human -DTXSID3021223 Css NA 0.0883 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021223 Css NA 0.512 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021223 Css NA 0.06152 mg/L PBTK NA 50% Rat Human -DTXSID3021223 Css NA 0.3287 mg/L PBTK NA 95% Rat Human -DTXSID3021275 Clint NA 1.442 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021275 Fup NA 0.6502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021275 Vd NA 0.9587 L/kg 1compartment NA NA Human Human +DTXSID3021223 TK.Half.Life NA 3.078 hours 1compartment NA NA Rat Human +DTXSID3021223 Css NA 0.03912 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021223 Css NA 0.1568 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021223 Css NA 0.03294 mg/L PBTK NA 50% Rat Human +DTXSID3021223 Css NA 0.1159 mg/L PBTK NA 95% Rat Human +DTXSID3021225 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021225 Fup 0.0474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021225 Vd NA 0.1851 L/kg 1compartment NA NA Human Human +DTXSID3021225 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3021225 TK.Half.Life NA 0.8136 hours 1compartment NA NA Human Human +DTXSID3021225 Css NA 0.3402 mg/L 3compartmentss NA 50% Human Human +DTXSID3021225 Css NA 3.106 mg/L 3compartmentss NA 95% Human Human +DTXSID3021225 Css NA 0.2001 mg/L PBTK NA 50% Human Human +DTXSID3021225 Css NA 1.804 mg/L PBTK NA 95% Human Human +DTXSID3021225 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021225 Fup 0.0474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021225 Vd NA 0.1856 L/kg 1compartment NA NA Rat Human +DTXSID3021225 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3021225 TK.Half.Life NA 0.5119 hours 1compartment NA NA Rat Human +DTXSID3021225 Css NA 0.003722 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021225 Css NA 0.0285 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021225 Css NA 0.002052 mg/L PBTK NA 50% Rat Human +DTXSID3021225 Css NA 0.01554 mg/L PBTK NA 95% Rat Human +DTXSID3021229 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021229 Fup 0.0747 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021229 Vd NA 0.2432 L/kg 1compartment NA NA Human Human +DTXSID3021229 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3021229 TK.Half.Life NA 0.7866 hours 1compartment NA NA Human Human +DTXSID3021229 Css NA 0.4082 mg/L 3compartmentss NA 50% Human Human +DTXSID3021229 Css NA 3.14 mg/L 3compartmentss NA 95% Human Human +DTXSID3021229 Css NA 0.2467 mg/L PBTK NA 50% Human Human +DTXSID3021229 Css NA 1.854 mg/L PBTK NA 95% Human Human +DTXSID3021229 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021229 Fup 0.0747 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021229 Vd NA 0.2451 L/kg 1compartment NA NA Rat Human +DTXSID3021229 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3021229 TK.Half.Life NA 0.4824 hours 1compartment NA NA Rat Human +DTXSID3021229 Css NA 0.05378 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021229 Css NA 0.3126 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021229 Css NA 0.03135 mg/L PBTK NA 50% Rat Human +DTXSID3021229 Css NA 0.1794 mg/L PBTK NA 95% Rat Human +DTXSID3021275 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021275 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021275 Vd NA 0.5677 L/kg 1compartment NA NA Human Human DTXSID3021275 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021275 TK.Half.Life NA 3.216 hours 1compartment NA NA Human Human -DTXSID3021275 Css NA 0.346 mg/L 3compartmentss NA 50% Human Human -DTXSID3021275 Css NA 2.559 mg/L 3compartmentss NA 95% Human Human -DTXSID3021275 Css NA 0.285 mg/L PBTK NA 50% Human Human -DTXSID3021275 Css NA 1.675 mg/L PBTK NA 95% Human Human -DTXSID3021275 Clint NA 1.442 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021275 Fup NA 0.6502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021275 Vd NA 0.8845 L/kg 1compartment NA NA Rat Human +DTXSID3021275 TK.Half.Life NA 9.047 hours 1compartment NA NA Human Human +DTXSID3021275 Css NA 1.685 mg/L 3compartmentss NA 50% Human Human +DTXSID3021275 Css NA 7.449 mg/L 3compartmentss NA 95% Human Human +DTXSID3021275 Css NA 1.288 mg/L PBTK NA 50% Human Human +DTXSID3021275 Css NA 4.743 mg/L PBTK NA 95% Human Human +DTXSID3021275 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021275 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021275 Vd NA 0.5722 L/kg 1compartment NA NA Rat Human DTXSID3021275 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021275 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human -DTXSID3021275 Css NA 0.1394 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021275 Css NA 0.9483 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021275 Css NA 0.1124 mg/L PBTK NA 50% Rat Human -DTXSID3021275 Css NA 0.5655 mg/L PBTK NA 95% Rat Human -DTXSID3021277 Clint NA 0.1054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021277 Fup NA 0.4084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021277 Vd NA 0.4686 L/kg 1compartment NA NA Human Human +DTXSID3021275 TK.Half.Life NA 3.108 hours 1compartment NA NA Rat Human +DTXSID3021275 Css NA 0.107 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021275 Css NA 0.4209 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021275 Css NA 0.08083 mg/L PBTK NA 50% Rat Human +DTXSID3021275 Css NA 0.261 mg/L PBTK NA 95% Rat Human +DTXSID3021277 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021277 Fup 0.428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021277 Vd NA 0.4802 L/kg 1compartment NA NA Human Human DTXSID3021277 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021277 TK.Half.Life NA 6.324 hours 1compartment NA NA Human Human -DTXSID3021277 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human -DTXSID3021277 Css NA 6.933 mg/L 3compartmentss NA 95% Human Human -DTXSID3021277 Css NA 1.089 mg/L PBTK NA 50% Human Human -DTXSID3021277 Css NA 4.333 mg/L PBTK NA 95% Human Human -DTXSID3021277 Clint NA 0.1054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021277 Fup NA 0.4084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021277 Vd NA 0.4707 L/kg 1compartment NA NA Rat Human +DTXSID3021277 TK.Half.Life NA 7.261 hours 1compartment NA NA Human Human +DTXSID3021277 Css NA 1.431 mg/L 3compartmentss NA 50% Human Human +DTXSID3021277 Css NA 6.418 mg/L 3compartmentss NA 95% Human Human +DTXSID3021277 Css NA 1.062 mg/L PBTK NA 50% Human Human +DTXSID3021277 Css NA 4.079 mg/L PBTK NA 95% Human Human +DTXSID3021277 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021277 Fup 0.428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021277 Vd NA 0.4829 L/kg 1compartment NA NA Rat Human DTXSID3021277 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021277 TK.Half.Life NA 2.343 hours 1compartment NA NA Rat Human -DTXSID3021277 Css NA 0.4484 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021277 Css NA 1.795 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021277 Css NA 0.3133 mg/L PBTK NA 50% Rat Human -DTXSID3021277 Css NA 1.053 mg/L PBTK NA 95% Rat Human +DTXSID3021277 TK.Half.Life NA 2.487 hours 1compartment NA NA Rat Human +DTXSID3021277 Css NA 0.02679 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021277 Css NA 0.1736 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021277 Css NA 0.01906 mg/L PBTK NA 50% Rat Human +DTXSID3021277 Css NA 0.1108 mg/L PBTK NA 95% Rat Human DTXSID3021304 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3021304 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021304 Vd NA 0.7075 L/kg 1compartment NA NA Human Human +DTXSID3021304 Vd NA 0.714 L/kg 1compartment NA NA Human Human DTXSID3021304 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021304 TK.Half.Life NA 4.578 hours 1compartment NA NA Human Human -DTXSID3021304 Css NA 0.8474 mg/L 3compartmentss NA 50% Human Human -DTXSID3021304 Css NA 5.542 mg/L 3compartmentss NA 95% Human Human -DTXSID3021304 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID3021304 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID3021304 TK.Half.Life NA 4.621 hours 1compartment NA NA Human Human +DTXSID3021304 Css NA 0.7074 mg/L 3compartmentss NA 50% Human Human +DTXSID3021304 Css NA 5.059 mg/L 3compartmentss NA 95% Human Human +DTXSID3021304 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID3021304 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID3021304 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3021304 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021304 Vd NA 0.7527 L/kg 1compartment NA NA Rat Human +DTXSID3021304 Vd NA 0.7561 L/kg 1compartment NA NA Rat Human DTXSID3021304 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021304 TK.Half.Life NA 1.659 hours 1compartment NA NA Rat Human -DTXSID3021304 Css NA 0.2131 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021304 Css NA 1.316 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021304 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID3021304 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID3021354 Clint NA 63.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021354 Fup NA 0.7977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021354 Vd NA 0.6529 L/kg 1compartment NA NA Human Human -DTXSID3021354 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021354 TK.Half.Life NA 0.4446 hours 1compartment NA NA Human Human -DTXSID3021354 Css NA 0.01039 mg/L 3compartmentss NA 50% Human Human -DTXSID3021354 Css NA 0.1047 mg/L 3compartmentss NA 95% Human Human -DTXSID3021354 Css NA 0.008144 mg/L PBTK NA 50% Human Human -DTXSID3021354 Css NA 0.07168 mg/L PBTK NA 95% Human Human -DTXSID3021354 Clint NA 63.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021354 Fup NA 0.7977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021354 Vd NA 0.689 L/kg 1compartment NA NA Rat Human -DTXSID3021354 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021354 TK.Half.Life NA 0.212 hours 1compartment NA NA Rat Human -DTXSID3021354 Css NA 0.005328 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021354 Css NA 0.04941 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021354 Css NA 0.004148 mg/L PBTK NA 50% Rat Human -DTXSID3021354 Css NA 0.033 mg/L PBTK NA 95% Rat Human -DTXSID3021356 Clint NA 410.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021356 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021356 Vd NA 969.8 L/kg 1compartment NA NA Human Human -DTXSID3021356 Days.Css NA 382 Days PBTK NA NA Human Human -DTXSID3021356 TK.Half.Life NA 1547 hours 1compartment NA NA Human Human -DTXSID3021356 Css NA 0.0008635 mg/L 3compartmentss NA 50% Human Human -DTXSID3021356 Css NA 0.00508 mg/L 3compartmentss NA 95% Human Human -DTXSID3021356 Css NA 0.1335 mg/L PBTK NA 50% Human Human -DTXSID3021356 Css NA 0.7373 mg/L PBTK NA 95% Human Human -DTXSID3021356 Clint NA 410.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021356 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021356 Vd NA 887.8 L/kg 1compartment NA NA Rat Human -DTXSID3021356 Days.Css NA 262 Days PBTK NA NA Rat Human -DTXSID3021356 TK.Half.Life NA 261.1 hours 1compartment NA NA Rat Human -DTXSID3021356 Css NA 0.0004378 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021356 Css NA 0.001865 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021356 Css NA 0.0717 mg/L PBTK NA 50% Rat Human -DTXSID3021356 Css NA 0.311 mg/L PBTK NA 95% Rat Human +DTXSID3021304 TK.Half.Life NA 1.667 hours 1compartment NA NA Rat Human +DTXSID3021304 Css NA 0.01298 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021304 Css NA 0.09988 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021304 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID3021304 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID3021358 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3021358 Fup 0.065 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3021358 Vd NA 0.2805 L/kg 1compartment NA NA Human Human DTXSID3021358 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID3021358 TK.Half.Life NA 27.94 hours 1compartment NA NA Human Human -DTXSID3021358 Css NA 11.26 mg/L 3compartmentss NA 50% Human Human -DTXSID3021358 Css NA 37.66 mg/L 3compartmentss NA 95% Human Human -DTXSID3021358 Css NA 7.047 mg/L PBTK NA 50% Human Human -DTXSID3021358 Css NA 22.51 mg/L PBTK NA 95% Human Human +DTXSID3021358 Css NA 10.73 mg/L 3compartmentss NA 50% Human Human +DTXSID3021358 Css NA 37.32 mg/L 3compartmentss NA 95% Human Human +DTXSID3021358 Css NA 6.726 mg/L PBTK NA 50% Human Human +DTXSID3021358 Css NA 22.19 mg/L PBTK NA 95% Human Human DTXSID3021358 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3021358 Fup 0.065 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3021358 Vd NA 0.2725 L/kg 1compartment NA NA Rat Human DTXSID3021358 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3021358 TK.Half.Life NA 9.246 hours 1compartment NA NA Rat Human -DTXSID3021358 Css NA 3.153 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021358 Css NA 8.834 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021358 Css NA 1.85 mg/L PBTK NA 50% Rat Human -DTXSID3021358 Css NA 4.926 mg/L PBTK NA 95% Rat Human -DTXSID3021483 Clint NA 3.523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021483 Fup NA 0.6652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021483 Vd NA 1.738 L/kg 1compartment NA NA Human Human +DTXSID3021358 Css NA 0.693 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021358 Css NA 1.991 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021358 Css NA 0.4208 mg/L PBTK NA 50% Rat Human +DTXSID3021358 Css NA 1.15 mg/L PBTK NA 95% Rat Human +DTXSID30213984 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30213984 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30213984 Vd NA 1.009 L/kg 1compartment NA NA Human Human +DTXSID30213984 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30213984 TK.Half.Life NA 7.108 hours 1compartment NA NA Human Human +DTXSID30213984 Css NA 0.8586 mg/L 3compartmentss NA 50% Human Human +DTXSID30213984 Css NA 4.897 mg/L 3compartmentss NA 95% Human Human +DTXSID30213984 Css NA 0.7399 mg/L PBTK NA 50% Human Human +DTXSID30213984 Css NA 3.204 mg/L PBTK NA 95% Human Human +DTXSID30213984 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30213984 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30213984 Vd NA 1.034 L/kg 1compartment NA NA Rat Human +DTXSID30213984 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30213984 TK.Half.Life NA 2.479 hours 1compartment NA NA Rat Human +DTXSID30213984 Css NA 0.05033 mg/L 3compartmentss NA 50% Rat Human +DTXSID30213984 Css NA 0.2821 mg/L 3compartmentss NA 95% Rat Human +DTXSID30213984 Css NA 0.04399 mg/L PBTK NA 50% Rat Human +DTXSID30213984 Css NA 0.1797 mg/L PBTK NA 95% Rat Human +DTXSID3021483 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021483 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021483 Vd NA 1.175 L/kg 1compartment NA NA Human Human DTXSID3021483 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021483 TK.Half.Life NA 3.809 hours 1compartment NA NA Human Human -DTXSID3021483 Css NA 0.1856 mg/L 3compartmentss NA 50% Human Human -DTXSID3021483 Css NA 1.463 mg/L 3compartmentss NA 95% Human Human -DTXSID3021483 Css NA 0.165 mg/L PBTK NA 50% Human Human -DTXSID3021483 Css NA 1.026 mg/L PBTK NA 95% Human Human -DTXSID3021483 Clint NA 3.523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021483 Fup NA 0.6652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021483 Vd NA 1.474 L/kg 1compartment NA NA Rat Human +DTXSID3021483 TK.Half.Life NA 1.512 hours 1compartment NA NA Human Human +DTXSID3021483 Css NA 0.06653 mg/L 3compartmentss NA 50% Human Human +DTXSID3021483 Css NA 0.5076 mg/L 3compartmentss NA 95% Human Human +DTXSID3021483 Css NA 0.04983 mg/L PBTK NA 50% Human Human +DTXSID3021483 Css NA 0.35 mg/L PBTK NA 95% Human Human +DTXSID3021483 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021483 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021483 Vd NA 0.9871 L/kg 1compartment NA NA Rat Human DTXSID3021483 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021483 TK.Half.Life NA 1.521 hours 1compartment NA NA Rat Human -DTXSID3021483 Css NA 0.08487 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021483 Css NA 0.5927 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021483 Css NA 0.07431 mg/L PBTK NA 50% Rat Human -DTXSID3021483 Css NA 0.3754 mg/L PBTK NA 95% Rat Human +DTXSID3021483 TK.Half.Life NA 0.646 hours 1compartment NA NA Rat Human +DTXSID3021483 Css NA 0.008225 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021483 Css NA 0.04726 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021483 Css NA 0.006233 mg/L PBTK NA 50% Rat Human +DTXSID3021483 Css NA 0.03197 mg/L PBTK NA 95% Rat Human DTXSID3021485 Clint NA 0.03491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3021485 Fup NA 0.1767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3021485 Vd NA 0.4287 L/kg 1compartment NA NA Human Human DTXSID3021485 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID3021485 TK.Half.Life NA 14.84 hours 1compartment NA NA Human Human -DTXSID3021485 Css NA 4.15 mg/L 3compartmentss NA 50% Human Human -DTXSID3021485 Css NA 16.05 mg/L 3compartmentss NA 95% Human Human -DTXSID3021485 Css NA 2.806 mg/L PBTK NA 50% Human Human -DTXSID3021485 Css NA 9.769 mg/L PBTK NA 95% Human Human +DTXSID3021485 Css NA 4.076 mg/L 3compartmentss NA 50% Human Human +DTXSID3021485 Css NA 15.45 mg/L 3compartmentss NA 95% Human Human +DTXSID3021485 Css NA 2.765 mg/L PBTK NA 50% Human Human +DTXSID3021485 Css NA 9.479 mg/L PBTK NA 95% Human Human DTXSID3021485 Clint NA 0.03491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3021485 Fup NA 0.1767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3021485 Vd NA 0.4276 L/kg 1compartment NA NA Rat Human DTXSID3021485 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021485 TK.Half.Life NA 5.188 hours 1compartment NA NA Rat Human -DTXSID3021485 Css NA 1.204 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021485 Css NA 3.944 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021485 Css NA 0.7701 mg/L PBTK NA 50% Rat Human -DTXSID3021485 Css NA 2.262 mg/L PBTK NA 95% Rat Human -DTXSID3021487 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021487 Fup NA 0.241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021487 Vd NA 0.4517 L/kg 1compartment NA NA Human Human +DTXSID3021485 TK.Half.Life NA 2.511 hours 1compartment NA NA Rat Human +DTXSID3021485 Css NA 0.1323 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021485 Css NA 0.4669 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021485 Css NA 0.08778 mg/L PBTK NA 50% Rat Human +DTXSID3021485 Css NA 0.2778 mg/L PBTK NA 95% Rat Human +DTXSID3021487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021487 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021487 Vd NA 0.4681 L/kg 1compartment NA NA Human Human DTXSID3021487 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3021487 TK.Half.Life NA 12.13 hours 1compartment NA NA Human Human -DTXSID3021487 Css NA 3.138 mg/L 3compartmentss NA 50% Human Human -DTXSID3021487 Css NA 11.88 mg/L 3compartmentss NA 95% Human Human -DTXSID3021487 Css NA 2.177 mg/L PBTK NA 50% Human Human -DTXSID3021487 Css NA 7.425 mg/L PBTK NA 95% Human Human -DTXSID3021487 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021487 Fup NA 0.241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021487 Vd NA 0.4562 L/kg 1compartment NA NA Rat Human +DTXSID3021487 TK.Half.Life NA 13.7 hours 1compartment NA NA Human Human +DTXSID3021487 Css NA 1.851 mg/L 3compartmentss NA 50% Human Human +DTXSID3021487 Css NA 7.493 mg/L 3compartmentss NA 95% Human Human +DTXSID3021487 Css NA 1.282 mg/L PBTK NA 50% Human Human +DTXSID3021487 Css NA 4.74 mg/L PBTK NA 95% Human Human +DTXSID3021487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021487 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021487 Vd NA 0.4698 L/kg 1compartment NA NA Rat Human DTXSID3021487 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021487 TK.Half.Life NA 4.173 hours 1compartment NA NA Rat Human -DTXSID3021487 Css NA 0.8792 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021487 Css NA 2.746 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021487 Css NA 0.5765 mg/L PBTK NA 50% Rat Human -DTXSID3021487 Css NA 1.597 mg/L PBTK NA 95% Rat Human +DTXSID3021487 TK.Half.Life NA 4.687 hours 1compartment NA NA Rat Human +DTXSID3021487 Css NA 0.009921 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021487 Css NA 0.04081 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021487 Css NA 0.006594 mg/L PBTK NA 50% Rat Human +DTXSID3021487 Css NA 0.02432 mg/L PBTK NA 95% Rat Human DTXSID3021518 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3021518 Fup NA 0.5925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3021518 Vd NA 0.5434 L/kg 1compartment NA NA Human Human DTXSID3021518 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3021518 TK.Half.Life NA 5.934 hours 1compartment NA NA Human Human -DTXSID3021518 Css NA 1.282 mg/L 3compartmentss NA 50% Human Human -DTXSID3021518 Css NA 8.733 mg/L 3compartmentss NA 95% Human Human -DTXSID3021518 Css NA 0.9898 mg/L PBTK NA 50% Human Human -DTXSID3021518 Css NA 5.464 mg/L PBTK NA 95% Human Human +DTXSID3021518 Css NA 1.096 mg/L 3compartmentss NA 50% Human Human +DTXSID3021518 Css NA 7.63 mg/L 3compartmentss NA 95% Human Human +DTXSID3021518 Css NA 0.8472 mg/L PBTK NA 50% Human Human +DTXSID3021518 Css NA 4.727 mg/L PBTK NA 95% Human Human DTXSID3021518 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3021518 Fup NA 0.5925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3021518 Vd NA 0.566 L/kg 1compartment NA NA Rat Human DTXSID3021518 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3021518 TK.Half.Life NA 2.106 hours 1compartment NA NA Rat Human -DTXSID3021518 Css NA 0.3387 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021518 Css NA 2.082 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021518 Css NA 0.2496 mg/L PBTK NA 50% Rat Human -DTXSID3021518 Css NA 1.209 mg/L PBTK NA 95% Rat Human -DTXSID3021562 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021562 Fup NA 0.8776 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021562 Vd NA 1.495 L/kg 1compartment NA NA Human Human -DTXSID3021562 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3021562 TK.Half.Life NA 12.43 hours 1compartment NA NA Human Human -DTXSID3021562 Css NA 0.8776 mg/L 3compartmentss NA 50% Human Human -DTXSID3021562 Css NA 5.124 mg/L 3compartmentss NA 95% Human Human -DTXSID3021562 Css NA 0.8182 mg/L PBTK NA 50% Human Human -DTXSID3021562 Css NA 3.518 mg/L PBTK NA 95% Human Human -DTXSID3021562 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021562 Fup NA 0.8776 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021562 Vd NA 1.351 L/kg 1compartment NA NA Rat Human -DTXSID3021562 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021562 TK.Half.Life NA 3.499 hours 1compartment NA NA Rat Human -DTXSID3021562 Css NA 0.2241 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021562 Css NA 1.416 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021562 Css NA 0.2051 mg/L PBTK NA 50% Rat Human -DTXSID3021562 Css NA 0.8877 mg/L PBTK NA 95% Rat Human -DTXSID3021641 Clint NA 0.724 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021641 Fup NA 0.1213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021641 Vd NA 0.486 L/kg 1compartment NA NA Human Human -DTXSID3021641 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3021641 TK.Half.Life NA 11.9 hours 1compartment NA NA Human Human -DTXSID3021641 Css NA 3.422 mg/L 3compartmentss NA 50% Human Human -DTXSID3021641 Css NA 18.11 mg/L 3compartmentss NA 95% Human Human -DTXSID3021641 Css NA 2.289 mg/L PBTK NA 50% Human Human -DTXSID3021641 Css NA 11.02 mg/L PBTK NA 95% Human Human -DTXSID3021641 Clint NA 0.724 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021641 Fup NA 0.1213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021641 Vd NA 0.454 L/kg 1compartment NA NA Rat Human +DTXSID3021518 Css NA 0.02086 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021518 Css NA 0.1762 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021518 Css NA 0.0154 mg/L PBTK NA 50% Rat Human +DTXSID3021518 Css NA 0.1088 mg/L PBTK NA 95% Rat Human +DTXSID30215640 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30215640 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30215640 Vd NA 1.179 L/kg 1compartment NA NA Human Human +DTXSID30215640 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30215640 TK.Half.Life NA 8.71 hours 1compartment NA NA Human Human +DTXSID30215640 Css NA 0.7569 mg/L 3compartmentss NA 50% Human Human +DTXSID30215640 Css NA 4.975 mg/L 3compartmentss NA 95% Human Human +DTXSID30215640 Css NA 0.5496 mg/L PBTK NA 50% Human Human +DTXSID30215640 Css NA 3.14 mg/L PBTK NA 95% Human Human +DTXSID30215640 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30215640 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30215640 Vd NA 1.173 L/kg 1compartment NA NA Rat Human +DTXSID30215640 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30215640 TK.Half.Life NA 5.005 hours 1compartment NA NA Rat Human +DTXSID30215640 Css NA 0.03118 mg/L 3compartmentss NA 50% Rat Human +DTXSID30215640 Css NA 0.2309 mg/L 3compartmentss NA 95% Rat Human +DTXSID30215640 Css NA 0.02261 mg/L PBTK NA 50% Rat Human +DTXSID30215640 Css NA 0.1455 mg/L PBTK NA 95% Rat Human +DTXSID3021641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021641 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021641 Vd NA 0.5407 L/kg 1compartment NA NA Human Human +DTXSID3021641 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3021641 TK.Half.Life NA 1.039 hours 1compartment NA NA Human Human +DTXSID3021641 Css NA 0.1624 mg/L 3compartmentss NA 50% Human Human +DTXSID3021641 Css NA 1.291 mg/L 3compartmentss NA 95% Human Human +DTXSID3021641 Css NA 0.1114 mg/L PBTK NA 50% Human Human +DTXSID3021641 Css NA 0.8302 mg/L PBTK NA 95% Human Human +DTXSID3021641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021641 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021641 Vd NA 0.5058 L/kg 1compartment NA NA Rat Human DTXSID3021641 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021641 TK.Half.Life NA 5.216 hours 1compartment NA NA Rat Human -DTXSID3021641 Css NA 1.368 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021641 Css NA 5.957 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021641 Css NA 0.8622 mg/L PBTK NA 50% Rat Human -DTXSID3021641 Css NA 3.366 mg/L PBTK NA 95% Rat Human -DTXSID3021645 Clint 5.626 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID3021645 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID3021645 Clint 5.626 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID3021645 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID3021647 Clint NA 0.005398 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021647 Fup NA 0.5694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021647 Vd NA 0.5586 L/kg 1compartment NA NA Human Human +DTXSID3021641 TK.Half.Life NA 0.5572 hours 1compartment NA NA Rat Human +DTXSID3021641 Css NA 0.02087 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021641 Css NA 0.1373 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021641 Css NA 0.01416 mg/L PBTK NA 50% Rat Human +DTXSID3021641 Css NA 0.08534 mg/L PBTK NA 95% Rat Human +DTXSID3021647 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021647 Fup 0.832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021647 Vd NA 0.7164 L/kg 1compartment NA NA Human Human DTXSID3021647 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021647 TK.Half.Life NA 6.29 hours 1compartment NA NA Human Human -DTXSID3021647 Css NA 1.304 mg/L 3compartmentss NA 50% Human Human -DTXSID3021647 Css NA 8.246 mg/L 3compartmentss NA 95% Human Human -DTXSID3021647 Css NA 1.011 mg/L PBTK NA 50% Human Human -DTXSID3021647 Css NA 5.135 mg/L PBTK NA 95% Human Human -DTXSID3021647 Clint NA 0.005398 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021647 Fup NA 0.5694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021647 Vd NA 0.5752 L/kg 1compartment NA NA Rat Human +DTXSID3021647 TK.Half.Life NA 5.572 hours 1compartment NA NA Human Human +DTXSID3021647 Css NA 0.8068 mg/L 3compartmentss NA 50% Human Human +DTXSID3021647 Css NA 4.986 mg/L 3compartmentss NA 95% Human Human +DTXSID3021647 Css NA 0.6774 mg/L PBTK NA 50% Human Human +DTXSID3021647 Css NA 3.256 mg/L PBTK NA 95% Human Human +DTXSID3021647 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021647 Fup 0.832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021647 Vd NA 0.7371 L/kg 1compartment NA NA Rat Human DTXSID3021647 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021647 TK.Half.Life NA 2.217 hours 1compartment NA NA Rat Human -DTXSID3021647 Css NA 0.3464 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021647 Css NA 2.244 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021647 Css NA 0.2568 mg/L PBTK NA 50% Rat Human -DTXSID3021647 Css NA 1.301 mg/L PBTK NA 95% Rat Human -DTXSID3021726 Clint NA 1.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021726 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021726 Vd NA 1.301 L/kg 1compartment NA NA Human Human +DTXSID3021647 TK.Half.Life NA 1.953 hours 1compartment NA NA Rat Human +DTXSID3021647 Css NA 0.01512 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021647 Css NA 0.12 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021647 Css NA 0.0122 mg/L PBTK NA 50% Rat Human +DTXSID3021647 Css NA 0.07903 mg/L PBTK NA 95% Rat Human +DTXSID3021726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021726 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021726 Vd NA 0.8555 L/kg 1compartment NA NA Human Human DTXSID3021726 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021726 TK.Half.Life NA 4.797 hours 1compartment NA NA Human Human -DTXSID3021726 Css NA 0.3638 mg/L 3compartmentss NA 50% Human Human -DTXSID3021726 Css NA 2.537 mg/L 3compartmentss NA 95% Human Human -DTXSID3021726 Css NA 0.3247 mg/L PBTK NA 50% Human Human -DTXSID3021726 Css NA 1.697 mg/L PBTK NA 95% Human Human -DTXSID3021726 Clint NA 1.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021726 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021726 Vd NA 1.176 L/kg 1compartment NA NA Rat Human +DTXSID3021726 TK.Half.Life NA 1.04 hours 1compartment NA NA Human Human +DTXSID3021726 Css NA 0.05776 mg/L 3compartmentss NA 50% Human Human +DTXSID3021726 Css NA 0.4643 mg/L 3compartmentss NA 95% Human Human +DTXSID3021726 Css NA 0.0428 mg/L PBTK NA 50% Human Human +DTXSID3021726 Css NA 0.3161 mg/L PBTK NA 95% Human Human +DTXSID3021726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021726 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021726 Vd NA 0.7677 L/kg 1compartment NA NA Rat Human DTXSID3021726 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021726 TK.Half.Life NA 2.011 hours 1compartment NA NA Rat Human -DTXSID3021726 Css NA 0.1402 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021726 Css NA 0.9825 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021726 Css NA 0.123 mg/L PBTK NA 50% Rat Human -DTXSID3021726 Css NA 0.603 mg/L PBTK NA 95% Rat Human +DTXSID3021726 TK.Half.Life NA 0.4837 hours 1compartment NA NA Rat Human +DTXSID3021726 Css NA 0.007333 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021726 Css NA 0.04515 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021726 Css NA 0.005444 mg/L PBTK NA 50% Rat Human +DTXSID3021726 Css NA 0.03021 mg/L PBTK NA 95% Rat Human DTXSID3021770 Clint 18.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3021770 Fup 0.00598 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3021770 Vd NA 20.05 L/kg 1compartment NA NA Human Human -DTXSID3021770 Days.Css NA 155 Days PBTK NA NA Human Human -DTXSID3021770 TK.Half.Life NA 663.9 hours 1compartment NA NA Human Human -DTXSID3021770 Css NA 1.332 mg/L 3compartmentss NA 50% Human Human -DTXSID3021770 Css NA 8.756 mg/L 3compartmentss NA 95% Human Human -DTXSID3021770 Css NA 2.812 mg/L PBTK NA 50% Human Human -DTXSID3021770 Css NA 16.13 mg/L PBTK NA 95% Human Human +DTXSID3021770 Vd NA 7.044 L/kg 1compartment NA NA Human Human +DTXSID3021770 Days.Css NA 47 Days PBTK NA NA Human Human +DTXSID3021770 TK.Half.Life NA 235.5 hours 1compartment NA NA Human Human +DTXSID3021770 Css NA 2.867 mg/L 3compartmentss NA 50% Human Human +DTXSID3021770 Css NA 18.36 mg/L 3compartmentss NA 95% Human Human +DTXSID3021770 Css NA 2.732 mg/L PBTK NA 50% Human Human +DTXSID3021770 Css NA 16.41 mg/L PBTK NA 95% Human Human DTXSID3021770 Clint 18.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3021770 Fup 0.00598 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3021770 Vd NA 16.28 L/kg 1compartment NA NA Rat Human -DTXSID3021770 Days.Css NA 94 Days PBTK NA NA Rat Human -DTXSID3021770 TK.Half.Life NA 102.8 hours 1compartment NA NA Rat Human -DTXSID3021770 Css NA 0.6871 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021770 Css NA 3.692 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021770 Css NA 1.515 mg/L PBTK NA 50% Rat Human -DTXSID3021770 Css NA 7.133 mg/L PBTK NA 95% Rat Human -DTXSID3021772 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021772 Fup NA 0.5687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021772 Vd NA 3.05 L/kg 1compartment NA NA Human Human -DTXSID3021772 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3021772 TK.Half.Life NA 34.74 hours 1compartment NA NA Human Human -DTXSID3021772 Css NA 0.8182 mg/L 3compartmentss NA 50% Human Human -DTXSID3021772 Css NA 7.749 mg/L 3compartmentss NA 95% Human Human -DTXSID3021772 Css NA 1.032 mg/L PBTK NA 50% Human Human -DTXSID3021772 Css NA 5.653 mg/L PBTK NA 95% Human Human -DTXSID3021772 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021772 Fup NA 0.5687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021772 Vd NA 3.041 L/kg 1compartment NA NA Rat Human -DTXSID3021772 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3021772 TK.Half.Life NA 11.8 hours 1compartment NA NA Rat Human -DTXSID3021772 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021772 Css NA 1.876 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021772 Css NA 0.261 mg/L PBTK NA 50% Rat Human -DTXSID3021772 Css NA 1.286 mg/L PBTK NA 95% Rat Human +DTXSID3021770 Vd NA 5.46 L/kg 1compartment NA NA Rat Human +DTXSID3021770 Days.Css NA 28 Days PBTK NA NA Rat Human +DTXSID3021770 TK.Half.Life NA 35.27 hours 1compartment NA NA Rat Human +DTXSID3021770 Css NA 0.3601 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021770 Css NA 1.873 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021770 Css NA 0.3527 mg/L PBTK NA 50% Rat Human +DTXSID3021770 Css NA 1.853 mg/L PBTK NA 95% Rat Human +DTXSID3021772 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021772 Fup 0.66 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021772 Vd NA 2.412 L/kg 1compartment NA NA Human Human +DTXSID3021772 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3021772 TK.Half.Life NA 23.65 hours 1compartment NA NA Human Human +DTXSID3021772 Css NA 0.7926 mg/L 3compartmentss NA 50% Human Human +DTXSID3021772 Css NA 6.428 mg/L 3compartmentss NA 95% Human Human +DTXSID3021772 Css NA 0.8892 mg/L PBTK NA 50% Human Human +DTXSID3021772 Css NA 4.537 mg/L PBTK NA 95% Human Human +DTXSID3021772 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021772 Fup 0.66 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021772 Vd NA 2.4 L/kg 1compartment NA NA Rat Human +DTXSID3021772 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3021772 TK.Half.Life NA 8.017 hours 1compartment NA NA Rat Human +DTXSID3021772 Css NA 0.04617 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021772 Css NA 0.3729 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021772 Css NA 0.05342 mg/L PBTK NA 50% Rat Human +DTXSID3021772 Css NA 0.255 mg/L PBTK NA 95% Rat Human DTXSID3021778 Clint 584 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3021778 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021778 Vd NA 1.571 L/kg 1compartment NA NA Human Human +DTXSID3021778 Fup 0.00299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021778 Vd NA 1.12 L/kg 1compartment NA NA Human Human DTXSID3021778 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021778 TK.Half.Life NA 1.986 hours 1compartment NA NA Human Human -DTXSID3021778 Css NA 0.06304 mg/L 3compartmentss NA 50% Human Human -DTXSID3021778 Css NA 0.6144 mg/L 3compartmentss NA 95% Human Human -DTXSID3021778 Css NA 0.03954 mg/L PBTK NA 50% Human Human -DTXSID3021778 Css NA 0.3755 mg/L PBTK NA 95% Human Human +DTXSID3021778 TK.Half.Life NA 2.469 hours 1compartment NA NA Human Human +DTXSID3021778 Css NA 0.2248 mg/L 3compartmentss NA 50% Human Human +DTXSID3021778 Css NA 1.903 mg/L 3compartmentss NA 95% Human Human +DTXSID3021778 Css NA 0.1356 mg/L PBTK NA 50% Human Human +DTXSID3021778 Css NA 1.122 mg/L PBTK NA 95% Human Human DTXSID3021778 Clint 584 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3021778 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021778 Vd NA 1.164 L/kg 1compartment NA NA Rat Human +DTXSID3021778 Fup 0.00299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021778 Vd NA 0.8197 L/kg 1compartment NA NA Rat Human DTXSID3021778 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021778 TK.Half.Life NA 0.6809 hours 1compartment NA NA Rat Human -DTXSID3021778 Css NA 0.03637 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021778 Css NA 0.2848 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021778 Css NA 0.02132 mg/L PBTK NA 50% Rat Human -DTXSID3021778 Css NA 0.1617 mg/L PBTK NA 95% Rat Human -DTXSID3021801 Clint NA 9.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021801 Fup NA 0.2392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021801 Vd NA 1.212 L/kg 1compartment NA NA Human Human +DTXSID3021778 TK.Half.Life NA 0.9575 hours 1compartment NA NA Rat Human +DTXSID3021778 Css NA 0.02995 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021778 Css NA 0.2198 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021778 Css NA 0.01749 mg/L PBTK NA 50% Rat Human +DTXSID3021778 Css NA 0.1268 mg/L PBTK NA 95% Rat Human +DTXSID3021801 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021801 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021801 Vd NA 1.576 L/kg 1compartment NA NA Human Human DTXSID3021801 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021801 TK.Half.Life NA 3.039 hours 1compartment NA NA Human Human -DTXSID3021801 Css NA 0.2188 mg/L 3compartmentss NA 50% Human Human -DTXSID3021801 Css NA 1.385 mg/L 3compartmentss NA 95% Human Human -DTXSID3021801 Css NA 0.1597 mg/L PBTK NA 50% Human Human -DTXSID3021801 Css NA 0.9268 mg/L PBTK NA 95% Human Human -DTXSID3021801 Clint NA 9.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021801 Fup NA 0.2392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021801 Vd NA 1.003 L/kg 1compartment NA NA Rat Human +DTXSID3021801 TK.Half.Life NA 1.831 hours 1compartment NA NA Human Human +DTXSID3021801 Css NA 0.05467 mg/L 3compartmentss NA 50% Human Human +DTXSID3021801 Css NA 0.4295 mg/L 3compartmentss NA 95% Human Human +DTXSID3021801 Css NA 0.04352 mg/L PBTK NA 50% Human Human +DTXSID3021801 Css NA 0.3118 mg/L PBTK NA 95% Human Human +DTXSID3021801 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021801 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021801 Vd NA 1.313 L/kg 1compartment NA NA Rat Human DTXSID3021801 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021801 TK.Half.Life NA 1.35 hours 1compartment NA NA Rat Human -DTXSID3021801 Css NA 0.1162 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021801 Css NA 0.5274 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021801 Css NA 0.08108 mg/L PBTK NA 50% Rat Human -DTXSID3021801 Css NA 0.3356 mg/L PBTK NA 95% Rat Human -DTXSID3021803 Clint NA 0.5637 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021803 Fup NA 0.5595 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021803 Vd NA 1.375 L/kg 1compartment NA NA Human Human +DTXSID3021801 TK.Half.Life NA 0.7381 hours 1compartment NA NA Rat Human +DTXSID3021801 Css NA 0.006664 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021801 Css NA 0.04097 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021801 Css NA 0.005389 mg/L PBTK NA 50% Rat Human +DTXSID3021801 Css NA 0.02946 mg/L PBTK NA 95% Rat Human +DTXSID3021803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021803 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021803 Vd NA 0.8369 L/kg 1compartment NA NA Human Human DTXSID3021803 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021803 TK.Half.Life NA 9.493 hours 1compartment NA NA Human Human -DTXSID3021803 Css NA 0.6774 mg/L 3compartmentss NA 50% Human Human -DTXSID3021803 Css NA 4.728 mg/L 3compartmentss NA 95% Human Human -DTXSID3021803 Css NA 0.5801 mg/L PBTK NA 50% Human Human -DTXSID3021803 Css NA 3.091 mg/L PBTK NA 95% Human Human -DTXSID3021803 Clint NA 0.5637 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021803 Fup NA 0.5595 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021803 Vd NA 1.194 L/kg 1compartment NA NA Rat Human +DTXSID3021803 TK.Half.Life NA 1.238 hours 1compartment NA NA Human Human +DTXSID3021803 Css NA 0.08732 mg/L 3compartmentss NA 50% Human Human +DTXSID3021803 Css NA 0.6388 mg/L 3compartmentss NA 95% Human Human +DTXSID3021803 Css NA 0.06156 mg/L PBTK NA 50% Human Human +DTXSID3021803 Css NA 0.4097 mg/L PBTK NA 95% Human Human +DTXSID3021803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021803 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021803 Vd NA 0.7246 L/kg 1compartment NA NA Rat Human DTXSID3021803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021803 TK.Half.Life NA 3.347 hours 1compartment NA NA Rat Human -DTXSID3021803 Css NA 0.2476 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021803 Css NA 1.56 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021803 Css NA 0.2046 mg/L PBTK NA 50% Rat Human -DTXSID3021803 Css NA 0.9479 mg/L PBTK NA 95% Rat Human -DTXSID3021805 Clint NA 92.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021805 Fup NA 0.1247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021805 Vd NA 1.869 L/kg 1compartment NA NA Human Human +DTXSID3021803 TK.Half.Life NA 0.5719 hours 1compartment NA NA Rat Human +DTXSID3021803 Css NA 0.01104 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021803 Css NA 0.05918 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021803 Css NA 0.00777 mg/L PBTK NA 50% Rat Human +DTXSID3021803 Css NA 0.0395 mg/L PBTK NA 95% Rat Human +DTXSID3021805 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021805 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021805 Vd NA 1.899 L/kg 1compartment NA NA Human Human DTXSID3021805 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021805 TK.Half.Life NA 1.753 hours 1compartment NA NA Human Human -DTXSID3021805 Css NA 0.03735 mg/L 3compartmentss NA 50% Human Human -DTXSID3021805 Css NA 0.375 mg/L 3compartmentss NA 95% Human Human -DTXSID3021805 Css NA 0.0301 mg/L PBTK NA 50% Human Human -DTXSID3021805 Css NA 0.2569 mg/L PBTK NA 95% Human Human -DTXSID3021805 Clint NA 92.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021805 Fup NA 0.1247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021805 Vd NA 1.865 L/kg 1compartment NA NA Rat Human +DTXSID3021805 TK.Half.Life NA 8.125 hours 1compartment NA NA Human Human +DTXSID3021805 Css NA 0.4468 mg/L 3compartmentss NA 50% Human Human +DTXSID3021805 Css NA 3.58 mg/L 3compartmentss NA 95% Human Human +DTXSID3021805 Css NA 0.366 mg/L PBTK NA 50% Human Human +DTXSID3021805 Css NA 2.449 mg/L PBTK NA 95% Human Human +DTXSID3021805 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021805 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021805 Vd NA 1.897 L/kg 1compartment NA NA Rat Human DTXSID3021805 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021805 TK.Half.Life NA 0.8965 hours 1compartment NA NA Rat Human -DTXSID3021805 Css NA 0.02101 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021805 Css NA 0.1578 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021805 Css NA 0.01622 mg/L PBTK NA 50% Rat Human -DTXSID3021805 Css NA 0.1053 mg/L PBTK NA 95% Rat Human -DTXSID3021851 Clint NA 12.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021851 Fup NA 0.1671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021851 Vd NA 2.601 L/kg 1compartment NA NA Human Human +DTXSID3021805 TK.Half.Life NA 4.965 hours 1compartment NA NA Rat Human +DTXSID3021805 Css NA 0.05413 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021805 Css NA 0.3399 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021805 Css NA 0.04396 mg/L PBTK NA 50% Rat Human +DTXSID3021805 Css NA 0.2219 mg/L PBTK NA 95% Rat Human +DTXSID3021851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021851 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021851 Vd NA 1.704 L/kg 1compartment NA NA Human Human DTXSID3021851 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021851 TK.Half.Life NA 12.87 hours 1compartment NA NA Human Human -DTXSID3021851 Css NA 0.5272 mg/L 3compartmentss NA 50% Human Human -DTXSID3021851 Css NA 3.173 mg/L 3compartmentss NA 95% Human Human -DTXSID3021851 Css NA 0.3792 mg/L PBTK NA 50% Human Human -DTXSID3021851 Css NA 2.124 mg/L PBTK NA 95% Human Human -DTXSID3021851 Clint NA 12.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021851 Fup NA 0.1671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021851 Vd NA 1.984 L/kg 1compartment NA NA Rat Human +DTXSID3021851 TK.Half.Life NA 2.88 hours 1compartment NA NA Human Human +DTXSID3021851 Css NA 0.1132 mg/L 3compartmentss NA 50% Human Human +DTXSID3021851 Css NA 0.7644 mg/L 3compartmentss NA 95% Human Human +DTXSID3021851 Css NA 0.08308 mg/L PBTK NA 50% Human Human +DTXSID3021851 Css NA 0.5231 mg/L PBTK NA 95% Human Human +DTXSID3021851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021851 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021851 Vd NA 1.362 L/kg 1compartment NA NA Rat Human DTXSID3021851 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021851 TK.Half.Life NA 3.259 hours 1compartment NA NA Rat Human -DTXSID3021851 Css NA 0.2861 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021851 Css NA 1.303 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021851 Css NA 0.197 mg/L PBTK NA 50% Rat Human -DTXSID3021851 Css NA 0.8469 mg/L PBTK NA 95% Rat Human +DTXSID3021851 TK.Half.Life NA 1.112 hours 1compartment NA NA Rat Human +DTXSID3021851 Css NA 0.01416 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021851 Css NA 0.07386 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021851 Css NA 0.01043 mg/L PBTK NA 50% Rat Human +DTXSID3021851 Css NA 0.05091 mg/L PBTK NA 95% Rat Human DTXSID3021853 Clint NA 0.1771 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3021853 Fup NA 0.8892 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021853 Vd NA 1.896 L/kg 1compartment NA NA Human Human +DTXSID3021853 Vd NA 1.581 L/kg 1compartment NA NA Human Human DTXSID3021853 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021853 TK.Half.Life NA 10.71 hours 1compartment NA NA Human Human -DTXSID3021853 Css NA 0.5862 mg/L 3compartmentss NA 50% Human Human -DTXSID3021853 Css NA 3.75 mg/L 3compartmentss NA 95% Human Human -DTXSID3021853 Css NA 0.5888 mg/L PBTK NA 50% Human Human -DTXSID3021853 Css NA 2.633 mg/L PBTK NA 95% Human Human +DTXSID3021853 TK.Half.Life NA 8.924 hours 1compartment NA NA Human Human +DTXSID3021853 Css NA 0.5898 mg/L 3compartmentss NA 50% Human Human +DTXSID3021853 Css NA 3.938 mg/L 3compartmentss NA 95% Human Human +DTXSID3021853 Css NA 0.5708 mg/L PBTK NA 50% Human Human +DTXSID3021853 Css NA 2.681 mg/L PBTK NA 95% Human Human DTXSID3021853 Clint NA 0.1771 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3021853 Fup NA 0.8892 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021853 Vd NA 1.927 L/kg 1compartment NA NA Rat Human +DTXSID3021853 Vd NA 1.618 L/kg 1compartment NA NA Rat Human DTXSID3021853 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021853 TK.Half.Life NA 4.191 hours 1compartment NA NA Rat Human -DTXSID3021853 Css NA 0.1668 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021853 Css NA 1.128 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021853 Css NA 0.1669 mg/L PBTK NA 50% Rat Human -DTXSID3021853 Css NA 0.7317 mg/L PBTK NA 95% Rat Human -DTXSID3021930 Clint NA 3.459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021930 Fup NA 0.6514 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021930 Vd NA 2.815 L/kg 1compartment NA NA Human Human -DTXSID3021930 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021930 TK.Half.Life NA 4.744 hours 1compartment NA NA Human Human -DTXSID3021930 Css NA 0.113 mg/L 3compartmentss NA 50% Human Human -DTXSID3021930 Css NA 1.214 mg/L 3compartmentss NA 95% Human Human -DTXSID3021930 Css NA 0.1383 mg/L PBTK NA 50% Human Human -DTXSID3021930 Css NA 0.9468 mg/L PBTK NA 95% Human Human -DTXSID3021930 Clint NA 3.459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021930 Fup NA 0.6514 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021930 Vd NA 2.788 L/kg 1compartment NA NA Rat Human -DTXSID3021930 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021930 TK.Half.Life NA 2.637 hours 1compartment NA NA Rat Human -DTXSID3021930 Css NA 0.05056 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021930 Css NA 0.4824 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021930 Css NA 0.0619 mg/L PBTK NA 50% Rat Human -DTXSID3021930 Css NA 0.3456 mg/L PBTK NA 95% Rat Human +DTXSID3021853 TK.Half.Life NA 3.515 hours 1compartment NA NA Rat Human +DTXSID3021853 Css NA 0.03943 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021853 Css NA 0.2563 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021853 Css NA 0.039 mg/L PBTK NA 50% Rat Human +DTXSID3021853 Css NA 0.1685 mg/L PBTK NA 95% Rat Human +DTXSID3021930 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021930 Fup 0.49 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021930 Vd NA 2.298 L/kg 1compartment NA NA Human Human +DTXSID3021930 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3021930 TK.Half.Life NA 30.36 hours 1compartment NA NA Human Human +DTXSID3021930 Css NA 0.8456 mg/L 3compartmentss NA 50% Human Human +DTXSID3021930 Css NA 5.552 mg/L 3compartmentss NA 95% Human Human +DTXSID3021930 Css NA 0.9486 mg/L PBTK NA 50% Human Human +DTXSID3021930 Css NA 4.149 mg/L PBTK NA 95% Human Human +DTXSID3021930 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021930 Fup 0.49 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021930 Vd NA 2.268 L/kg 1compartment NA NA Rat Human +DTXSID3021930 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3021930 TK.Half.Life NA 10.21 hours 1compartment NA NA Rat Human +DTXSID3021930 Css NA 0.01573 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021930 Css NA 0.1313 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021930 Css NA 0.01728 mg/L PBTK NA 50% Rat Human +DTXSID3021930 Css NA 0.1065 mg/L PBTK NA 95% Rat Human DTXSID3021932 Clint NA 0.779 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3021932 Fup NA 0.8906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3021932 Vd NA 1.651 L/kg 1compartment NA NA Human Human DTXSID3021932 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3021932 TK.Half.Life NA 5.479 hours 1compartment NA NA Human Human -DTXSID3021932 Css NA 0.3518 mg/L 3compartmentss NA 50% Human Human -DTXSID3021932 Css NA 2.353 mg/L 3compartmentss NA 95% Human Human -DTXSID3021932 Css NA 0.3396 mg/L PBTK NA 50% Human Human -DTXSID3021932 Css NA 1.643 mg/L PBTK NA 95% Human Human +DTXSID3021932 Css NA 0.2952 mg/L 3compartmentss NA 50% Human Human +DTXSID3021932 Css NA 2 mg/L 3compartmentss NA 95% Human Human +DTXSID3021932 Css NA 0.2856 mg/L PBTK NA 50% Human Human +DTXSID3021932 Css NA 1.391 mg/L PBTK NA 95% Human Human DTXSID3021932 Clint NA 0.779 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3021932 Fup NA 0.8906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3021932 Vd NA 1.691 L/kg 1compartment NA NA Rat Human DTXSID3021932 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3021932 TK.Half.Life NA 2.624 hours 1compartment NA NA Rat Human -DTXSID3021932 Css NA 0.1221 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021932 Css NA 0.8122 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021932 Css NA 0.1185 mg/L PBTK NA 50% Rat Human -DTXSID3021932 Css NA 0.5185 mg/L PBTK NA 95% Rat Human -DTXSID3021936 Clint NA 0.03426 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021936 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021936 Vd NA 0.8798 L/kg 1compartment NA NA Human Human +DTXSID3021932 Css NA 0.007628 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021932 Css NA 0.06261 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021932 Css NA 0.007156 mg/L PBTK NA 50% Rat Human +DTXSID3021932 Css NA 0.04542 mg/L PBTK NA 95% Rat Human +DTXSID3021936 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021936 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3021936 Vd NA 0.6864 L/kg 1compartment NA NA Human Human DTXSID3021936 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021936 TK.Half.Life NA 5.407 hours 1compartment NA NA Human Human -DTXSID3021936 Css NA 0.7495 mg/L 3compartmentss NA 50% Human Human -DTXSID3021936 Css NA 5.012 mg/L 3compartmentss NA 95% Human Human -DTXSID3021936 Css NA 0.6506 mg/L PBTK NA 50% Human Human -DTXSID3021936 Css NA 3.273 mg/L PBTK NA 95% Human Human -DTXSID3021936 Clint NA 0.03426 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021936 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021936 Vd NA 0.903 L/kg 1compartment NA NA Rat Human +DTXSID3021936 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human +DTXSID3021936 Css NA 1.093 mg/L 3compartmentss NA 50% Human Human +DTXSID3021936 Css NA 7.367 mg/L 3compartmentss NA 95% Human Human +DTXSID3021936 Css NA 0.8874 mg/L PBTK NA 50% Human Human +DTXSID3021936 Css NA 4.731 mg/L PBTK NA 95% Human Human +DTXSID3021936 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021936 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3021936 Vd NA 0.7035 L/kg 1compartment NA NA Rat Human DTXSID3021936 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021936 TK.Half.Life NA 1.939 hours 1compartment NA NA Rat Human -DTXSID3021936 Css NA 0.1978 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021936 Css NA 1.264 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021936 Css NA 0.1681 mg/L PBTK NA 50% Rat Human -DTXSID3021936 Css NA 0.7683 mg/L PBTK NA 95% Rat Human -DTXSID3021984 Clint NA 36.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021984 Fup NA 0.1489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3021984 Vd NA 4.053 L/kg 1compartment NA NA Human Human -DTXSID3021984 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3021984 TK.Half.Life NA 2.081 hours 1compartment NA NA Human Human -DTXSID3021984 Css NA 0.01003 mg/L 3compartmentss NA 50% Human Human -DTXSID3021984 Css NA 0.1089 mg/L 3compartmentss NA 95% Human Human -DTXSID3021984 Css NA 0.01322 mg/L PBTK NA 50% Human Human -DTXSID3021984 Css NA 0.1016 mg/L PBTK NA 95% Human Human -DTXSID3021984 Clint NA 36.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021984 Fup NA 0.1489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3021984 Vd NA 3.967 L/kg 1compartment NA NA Rat Human -DTXSID3021984 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3021984 TK.Half.Life NA 0.9867 hours 1compartment NA NA Rat Human -DTXSID3021984 Css NA 0.005421 mg/L 3compartmentss NA 50% Rat Human -DTXSID3021984 Css NA 0.04556 mg/L 3compartmentss NA 95% Rat Human -DTXSID3021984 Css NA 0.007116 mg/L PBTK NA 50% Rat Human -DTXSID3021984 Css NA 0.04427 mg/L PBTK NA 95% Rat Human +DTXSID3021936 TK.Half.Life NA 2.338 hours 1compartment NA NA Rat Human +DTXSID3021936 Css NA 0.06628 mg/L 3compartmentss NA 50% Rat Human +DTXSID3021936 Css NA 0.4208 mg/L 3compartmentss NA 95% Rat Human +DTXSID3021936 Css NA 0.05324 mg/L PBTK NA 50% Rat Human +DTXSID3021936 Css NA 0.2566 mg/L PBTK NA 95% Rat Human DTXSID3021986 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3021986 Fup 0.03481 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3021986 Vd NA 2.55 L/kg 1compartment NA NA Human Human -DTXSID3021986 Days.Css NA 444 Days PBTK NA NA Human Human +DTXSID3021986 Days.Css NA 440 Days PBTK NA NA Human Human DTXSID3021986 TK.Half.Life NA 1679 hours 1compartment NA NA Human Human -DTXSID3021986 Css NA 88.36 mg/L 3compartmentss NA 50% Human Human +DTXSID3021986 Css NA 85.07 mg/L 3compartmentss NA 50% Human Human DTXSID3021986 Css NA 271.1 mg/L 3compartmentss NA 95% Human Human -DTXSID3021986 Css NA 59.04 mg/L PBTK NA 50% Human Human -DTXSID3021986 Css NA 170.8 mg/L PBTK NA 95% Human Human +DTXSID3021986 Css NA 56.74 mg/L PBTK NA 50% Human Human +DTXSID3021986 Css NA 169.8 mg/L PBTK NA 95% Human Human DTXSID3021986 Clint 60.2 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID3021986 Fup 0.0257 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID3021986 Vd NA 1.788 L/kg 1compartment NA NA Rat Rat DTXSID3021986 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID3021986 TK.Half.Life NA 2.837 hours 1compartment NA NA Rat Rat -DTXSID3021986 Css NA 0.2956 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3021986 Css NA 1.879 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3021986 Css NA 0.1851 mg/L PBTK NA 50% Rat Rat -DTXSID3021986 Css NA 1.109 mg/L PBTK NA 95% Rat Rat -DTXSID3022035 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022035 Fup NA 0.2953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022035 Vd NA 2.695 L/kg 1compartment NA NA Human Human -DTXSID3022035 Days.Css NA 47 Days PBTK NA NA Human Human -DTXSID3022035 TK.Half.Life NA 222.9 hours 1compartment NA NA Human Human -DTXSID3022035 Css NA 8.956 mg/L 3compartmentss NA 50% Human Human -DTXSID3022035 Css NA 27.38 mg/L 3compartmentss NA 95% Human Human -DTXSID3022035 Css NA 6.67 mg/L PBTK NA 50% Human Human -DTXSID3022035 Css NA 18.45 mg/L PBTK NA 95% Human Human -DTXSID3022035 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022035 Fup NA 0.2953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022035 Vd NA 2.059 L/kg 1compartment NA NA Rat Human -DTXSID3022035 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID3022035 TK.Half.Life NA 25.55 hours 1compartment NA NA Rat Human -DTXSID3022035 Css NA 2.443 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022035 Css NA 5.836 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022035 Css NA 1.752 mg/L PBTK NA 50% Rat Human -DTXSID3022035 Css NA 3.648 mg/L PBTK NA 95% Rat Human -DTXSID3022085 Clint NA 128.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022085 Fup NA 0.3569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022085 Vd NA 1.299 L/kg 1compartment NA NA Human Human +DTXSID3021986 Css NA 0.06662 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3021986 Css NA 0.4295 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3021986 Css NA 0.04314 mg/L PBTK NA 50% Rat Rat +DTXSID3021986 Css NA 0.2664 mg/L PBTK NA 95% Rat Rat +DTXSID3022035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022035 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022035 Vd NA 2.602 L/kg 1compartment NA NA Human Human +DTXSID3022035 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022035 TK.Half.Life NA 6.601 hours 1compartment NA NA Human Human +DTXSID3022035 Css NA 0.2102 mg/L 3compartmentss NA 50% Human Human +DTXSID3022035 Css NA 1.333 mg/L 3compartmentss NA 95% Human Human +DTXSID3022035 Css NA 0.154 mg/L PBTK NA 50% Human Human +DTXSID3022035 Css NA 0.9334 mg/L PBTK NA 95% Human Human +DTXSID3022035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022035 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022035 Vd NA 1.985 L/kg 1compartment NA NA Rat Human +DTXSID3022035 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022035 TK.Half.Life NA 1.757 hours 1compartment NA NA Rat Human +DTXSID3022035 Css NA 0.02632 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022035 Css NA 0.1295 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022035 Css NA 0.01928 mg/L PBTK NA 50% Rat Human +DTXSID3022035 Css NA 0.09105 mg/L PBTK NA 95% Rat Human +DTXSID3022085 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022085 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022085 Vd NA 1.012 L/kg 1compartment NA NA Human Human DTXSID3022085 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022085 TK.Half.Life NA 1.029 hours 1compartment NA NA Human Human -DTXSID3022085 Css NA 0.01098 mg/L 3compartmentss NA 50% Human Human -DTXSID3022085 Css NA 0.08717 mg/L 3compartmentss NA 95% Human Human -DTXSID3022085 Css NA 0.008414 mg/L PBTK NA 50% Human Human -DTXSID3022085 Css NA 0.06105 mg/L PBTK NA 95% Human Human -DTXSID3022085 Clint NA 128.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022085 Fup NA 0.3569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022085 Vd NA 1.082 L/kg 1compartment NA NA Rat Human +DTXSID3022085 TK.Half.Life NA 1.581 hours 1compartment NA NA Human Human +DTXSID3022085 Css NA 0.09744 mg/L 3compartmentss NA 50% Human Human +DTXSID3022085 Css NA 0.7109 mg/L 3compartmentss NA 95% Human Human +DTXSID3022085 Css NA 0.06858 mg/L PBTK NA 50% Human Human +DTXSID3022085 Css NA 0.4674 mg/L PBTK NA 95% Human Human +DTXSID3022085 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022085 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022085 Vd NA 0.839 L/kg 1compartment NA NA Rat Human DTXSID3022085 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022085 TK.Half.Life NA 0.3864 hours 1compartment NA NA Rat Human -DTXSID3022085 Css NA 0.005931 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022085 Css NA 0.03815 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022085 Css NA 0.004449 mg/L PBTK NA 50% Rat Human -DTXSID3022085 Css NA 0.02679 mg/L PBTK NA 95% Rat Human -DTXSID3022089 Clint NA 0.4994 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022089 Fup NA 0.7573 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022089 Vd NA 1.014 L/kg 1compartment NA NA Human Human +DTXSID3022085 TK.Half.Life NA 0.6911 hours 1compartment NA NA Rat Human +DTXSID3022085 Css NA 0.0123 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022085 Css NA 0.06845 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022085 Css NA 0.008645 mg/L PBTK NA 50% Rat Human +DTXSID3022085 Css NA 0.04517 mg/L PBTK NA 95% Rat Human +DTXSID3022089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022089 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022089 Vd NA 0.6787 L/kg 1compartment NA NA Human Human DTXSID3022089 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022089 TK.Half.Life NA 4.98 hours 1compartment NA NA Human Human -DTXSID3022089 Css NA 0.5303 mg/L 3compartmentss NA 50% Human Human -DTXSID3022089 Css NA 3.459 mg/L 3compartmentss NA 95% Human Human -DTXSID3022089 Css NA 0.462 mg/L PBTK NA 50% Human Human -DTXSID3022089 Css NA 2.264 mg/L PBTK NA 95% Human Human -DTXSID3022089 Clint NA 0.4994 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022089 Fup NA 0.7573 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022089 Vd NA 0.9749 L/kg 1compartment NA NA Rat Human +DTXSID3022089 TK.Half.Life NA 0.7826 hours 1compartment NA NA Human Human +DTXSID3022089 Css NA 0.05164 mg/L 3compartmentss NA 50% Human Human +DTXSID3022089 Css NA 0.4168 mg/L 3compartmentss NA 95% Human Human +DTXSID3022089 Css NA 0.03812 mg/L PBTK NA 50% Human Human +DTXSID3022089 Css NA 0.278 mg/L PBTK NA 95% Human Human +DTXSID3022089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022089 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022089 Vd NA 0.6493 L/kg 1compartment NA NA Rat Human DTXSID3022089 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022089 TK.Half.Life NA 2.054 hours 1compartment NA NA Rat Human -DTXSID3022089 Css NA 0.1797 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022089 Css NA 1.182 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022089 Css NA 0.1522 mg/L PBTK NA 50% Rat Human -DTXSID3022089 Css NA 0.7154 mg/L PBTK NA 95% Rat Human -DTXSID3022160 Clint NA 6.869 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022160 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022160 Vd NA 1.38 L/kg 1compartment NA NA Human Human +DTXSID3022089 TK.Half.Life NA 0.387 hours 1compartment NA NA Rat Human +DTXSID3022089 Css NA 0.006414 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022089 Css NA 0.0383 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022089 Css NA 0.004763 mg/L PBTK NA 50% Rat Human +DTXSID3022089 Css NA 0.0256 mg/L PBTK NA 95% Rat Human +DTXSID3022114 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022114 Fup 0.455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022114 Vd NA 2.717 L/kg 1compartment NA NA Human Human +DTXSID3022114 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022114 TK.Half.Life NA 2.459 hours 1compartment NA NA Human Human +DTXSID3022114 Css NA 0.03463 mg/L 3compartmentss NA 50% Human Human +DTXSID3022114 Css NA 0.3223 mg/L 3compartmentss NA 95% Human Human +DTXSID3022114 Css NA 0.03482 mg/L PBTK NA 50% Human Human +DTXSID3022114 Css NA 0.2636 mg/L PBTK NA 95% Human Human +DTXSID3022114 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022114 Fup 0.455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022114 Vd NA 2.624 L/kg 1compartment NA NA Rat Human +DTXSID3022114 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022114 TK.Half.Life NA 1.198 hours 1compartment NA NA Rat Human +DTXSID3022114 Css NA 0.004199 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022114 Css NA 0.03027 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022114 Css NA 0.004368 mg/L PBTK NA 50% Rat Human +DTXSID3022114 Css NA 0.0242 mg/L PBTK NA 95% Rat Human +DTXSID3022160 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022160 Fup 0.0182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022160 Vd NA 1.527 L/kg 1compartment NA NA Human Human DTXSID3022160 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3022160 TK.Half.Life NA 17.94 hours 1compartment NA NA Human Human -DTXSID3022160 Css NA 2.06 mg/L 3compartmentss NA 50% Human Human -DTXSID3022160 Css NA 13.26 mg/L 3compartmentss NA 95% Human Human -DTXSID3022160 Css NA 1.312 mg/L PBTK NA 50% Human Human -DTXSID3022160 Css NA 8.083 mg/L PBTK NA 95% Human Human -DTXSID3022160 Clint NA 6.869 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022160 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022160 Vd NA 1.037 L/kg 1compartment NA NA Rat Human +DTXSID3022160 TK.Half.Life NA 15.12 hours 1compartment NA NA Human Human +DTXSID3022160 Css NA 1.544 mg/L 3compartmentss NA 50% Human Human +DTXSID3022160 Css NA 14.36 mg/L 3compartmentss NA 95% Human Human +DTXSID3022160 Css NA 0.962 mg/L PBTK NA 50% Human Human +DTXSID3022160 Css NA 8.724 mg/L PBTK NA 95% Human Human +DTXSID3022160 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022160 Fup 0.0182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022160 Vd NA 1.131 L/kg 1compartment NA NA Rat Human DTXSID3022160 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022160 TK.Half.Life NA 7.026 hours 1compartment NA NA Rat Human -DTXSID3022160 Css NA 1.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022160 Css NA 5.248 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022160 Css NA 0.6671 mg/L PBTK NA 50% Rat Human -DTXSID3022160 Css NA 2.977 mg/L PBTK NA 95% Rat Human +DTXSID3022160 TK.Half.Life NA 5.767 hours 1compartment NA NA Rat Human +DTXSID3022160 Css NA 0.1992 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022160 Css NA 1.453 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022160 Css NA 0.1214 mg/L PBTK NA 50% Rat Human +DTXSID3022160 Css NA 0.8427 mg/L PBTK NA 95% Rat Human DTXSID3022162 Clint 7.866 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3022162 Fup 0.5001 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3022162 Vd NA 2.909 L/kg 1compartment NA NA Human Human +DTXSID3022162 Vd NA 2.916 L/kg 1compartment NA NA Human Human DTXSID3022162 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022162 TK.Half.Life NA 3.26 hours 1compartment NA NA Human Human -DTXSID3022162 Css NA 0.03666 mg/L 3compartmentss NA 50% Human Human -DTXSID3022162 Css NA 0.4169 mg/L 3compartmentss NA 95% Human Human -DTXSID3022162 Css NA 0.08805 mg/L PBTK NA 50% Human Human -DTXSID3022162 Css NA 0.5689 mg/L PBTK NA 95% Human Human +DTXSID3022162 TK.Half.Life NA 3.293 hours 1compartment NA NA Human Human +DTXSID3022162 Css NA 0.03531 mg/L 3compartmentss NA 50% Human Human +DTXSID3022162 Css NA 0.4136 mg/L 3compartmentss NA 95% Human Human +DTXSID3022162 Css NA 0.08312 mg/L PBTK NA 50% Human Human +DTXSID3022162 Css NA 0.5494 mg/L PBTK NA 95% Human Human DTXSID3022162 Clint 7.866 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3022162 Fup 0.5001 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID3022162 Vd NA 2.882 L/kg 1compartment NA NA Rat Human +DTXSID3022162 Vd NA 2.884 L/kg 1compartment NA NA Rat Human DTXSID3022162 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022162 TK.Half.Life NA 1.921 hours 1compartment NA NA Rat Human -DTXSID3022162 Css NA 0.0174 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022162 Css NA 0.1806 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022162 Css NA 0.04352 mg/L PBTK NA 50% Rat Human -DTXSID3022162 Css NA 0.2157 mg/L PBTK NA 95% Rat Human -DTXSID3022164 Clint NA 5.224 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022164 Fup NA 0.2824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022164 Vd NA 1.804 L/kg 1compartment NA NA Human Human +DTXSID3022162 TK.Half.Life NA 1.924 hours 1compartment NA NA Rat Human +DTXSID3022162 Css NA 0.003892 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022162 Css NA 0.04055 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022162 Css NA 0.01008 mg/L PBTK NA 50% Rat Human +DTXSID3022162 Css NA 0.04938 mg/L PBTK NA 95% Rat Human +DTXSID3022164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022164 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022164 Vd NA 1.626 L/kg 1compartment NA NA Human Human DTXSID3022164 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022164 TK.Half.Life NA 6.89 hours 1compartment NA NA Human Human -DTXSID3022164 Css NA 0.3721 mg/L 3compartmentss NA 50% Human Human -DTXSID3022164 Css NA 2.061 mg/L 3compartmentss NA 95% Human Human -DTXSID3022164 Css NA 0.2812 mg/L PBTK NA 50% Human Human -DTXSID3022164 Css NA 1.446 mg/L PBTK NA 95% Human Human -DTXSID3022164 Clint NA 5.224 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022164 Fup NA 0.2824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022164 Vd NA 1.424 L/kg 1compartment NA NA Rat Human +DTXSID3022164 TK.Half.Life NA 3.366 hours 1compartment NA NA Human Human +DTXSID3022164 Css NA 0.1591 mg/L 3compartmentss NA 50% Human Human +DTXSID3022164 Css NA 1.102 mg/L 3compartmentss NA 95% Human Human +DTXSID3022164 Css NA 0.1114 mg/L PBTK NA 50% Human Human +DTXSID3022164 Css NA 0.7294 mg/L PBTK NA 95% Human Human +DTXSID3022164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022164 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022164 Vd NA 1.263 L/kg 1compartment NA NA Rat Human DTXSID3022164 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022164 TK.Half.Life NA 2.488 hours 1compartment NA NA Rat Human -DTXSID3022164 Css NA 0.1889 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022164 Css NA 0.746 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022164 Css NA 0.1378 mg/L PBTK NA 50% Rat Human -DTXSID3022164 Css NA 0.4874 mg/L PBTK NA 95% Rat Human -DTXSID3022247 Clint NA 69.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022247 Fup NA 0.0517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022247 Vd NA 3.072 L/kg 1compartment NA NA Human Human -DTXSID3022247 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3022247 TK.Half.Life NA 19.18 hours 1compartment NA NA Human Human -DTXSID3022247 Css NA 0.6946 mg/L 3compartmentss NA 50% Human Human -DTXSID3022247 Css NA 4.442 mg/L 3compartmentss NA 95% Human Human -DTXSID3022247 Css NA 0.4811 mg/L PBTK NA 50% Human Human -DTXSID3022247 Css NA 3 mg/L PBTK NA 95% Human Human -DTXSID3022247 Clint NA 69.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022247 Fup NA 0.0517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022247 Vd NA 2.302 L/kg 1compartment NA NA Rat Human -DTXSID3022247 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022247 TK.Half.Life NA 3.144 hours 1compartment NA NA Rat Human -DTXSID3022247 Css NA 0.3876 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022247 Css NA 2.109 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022247 Css NA 0.2567 mg/L PBTK NA 50% Rat Human -DTXSID3022247 Css NA 1.379 mg/L PBTK NA 95% Rat Human -DTXSID3022320 Clint NA 36.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022320 Fup NA 0.0218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022320 Vd NA 3.117 L/kg 1compartment NA NA Human Human -DTXSID3022320 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID3022320 TK.Half.Life NA 53.24 hours 1compartment NA NA Human Human -DTXSID3022320 Css NA 2.039 mg/L 3compartmentss NA 50% Human Human -DTXSID3022320 Css NA 12.49 mg/L 3compartmentss NA 95% Human Human -DTXSID3022320 Css NA 1.413 mg/L PBTK NA 50% Human Human -DTXSID3022320 Css NA 8.394 mg/L PBTK NA 95% Human Human -DTXSID3022320 Clint NA 36.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022320 Fup NA 0.0218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022320 Vd NA 2.334 L/kg 1compartment NA NA Rat Human -DTXSID3022320 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID3022320 TK.Half.Life NA 7.411 hours 1compartment NA NA Rat Human -DTXSID3022320 Css NA 1.138 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022320 Css NA 5.483 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022320 Css NA 0.755 mg/L PBTK NA 50% Rat Human -DTXSID3022320 Css NA 3.61 mg/L PBTK NA 95% Rat Human -DTXSID3022326 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022326 Fup NA 0.2847 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022326 Vd NA 0.4998 L/kg 1compartment NA NA Human Human +DTXSID3022164 TK.Half.Life NA 1.272 hours 1compartment NA NA Rat Human +DTXSID3022164 Css NA 0.02026 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022164 Css NA 0.1059 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022164 Css NA 0.01418 mg/L PBTK NA 50% Rat Human +DTXSID3022164 Css NA 0.07028 mg/L PBTK NA 95% Rat Human +DTXSID3022247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022247 Fup 0.0235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022247 Vd NA 2.82 L/kg 1compartment NA NA Human Human +DTXSID3022247 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID3022247 TK.Half.Life NA 41.36 hours 1compartment NA NA Human Human +DTXSID3022247 Css NA 1.892 mg/L 3compartmentss NA 50% Human Human +DTXSID3022247 Css NA 13.53 mg/L 3compartmentss NA 95% Human Human +DTXSID3022247 Css NA 1.276 mg/L PBTK NA 50% Human Human +DTXSID3022247 Css NA 8.741 mg/L PBTK NA 95% Human Human +DTXSID3022247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022247 Fup 0.0235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022247 Vd NA 2.109 L/kg 1compartment NA NA Rat Human +DTXSID3022247 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3022247 TK.Half.Life NA 8.006 hours 1compartment NA NA Rat Human +DTXSID3022247 Css NA 0.2447 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022247 Css NA 1.429 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022247 Css NA 0.1633 mg/L PBTK NA 50% Rat Human +DTXSID3022247 Css NA 0.9297 mg/L PBTK NA 95% Rat Human +DTXSID3022295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022295 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022295 Vd NA 1.539 L/kg 1compartment NA NA Human Human +DTXSID3022295 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022295 TK.Half.Life NA 3.227 hours 1compartment NA NA Human Human +DTXSID3022295 Css NA 0.1778 mg/L 3compartmentss NA 50% Human Human +DTXSID3022295 Css NA 1.34 mg/L 3compartmentss NA 95% Human Human +DTXSID3022295 Css NA 0.1236 mg/L PBTK NA 50% Human Human +DTXSID3022295 Css NA 0.8586 mg/L PBTK NA 95% Human Human +DTXSID3022295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022295 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022295 Vd NA 1.198 L/kg 1compartment NA NA Rat Human +DTXSID3022295 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022295 TK.Half.Life NA 1.247 hours 1compartment NA NA Rat Human +DTXSID3022295 Css NA 0.0229 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022295 Css NA 0.126 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022295 Css NA 0.01568 mg/L PBTK NA 50% Rat Human +DTXSID3022295 Css NA 0.07846 mg/L PBTK NA 95% Rat Human +DTXSID3022320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022320 Fup 0.00426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022320 Vd NA 3.012 L/kg 1compartment NA NA Human Human +DTXSID3022320 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID3022320 TK.Half.Life NA 88.62 hours 1compartment NA NA Human Human +DTXSID3022320 Css NA 3.676 mg/L 3compartmentss NA 50% Human Human +DTXSID3022320 Css NA 23.45 mg/L 3compartmentss NA 95% Human Human +DTXSID3022320 Css NA 2.527 mg/L PBTK NA 50% Human Human +DTXSID3022320 Css NA 15.72 mg/L PBTK NA 95% Human Human +DTXSID3022320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022320 Fup 0.00426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022320 Vd NA 2.254 L/kg 1compartment NA NA Rat Human +DTXSID3022320 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID3022320 TK.Half.Life NA 13.66 hours 1compartment NA NA Rat Human +DTXSID3022320 Css NA 0.4724 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022320 Css NA 2.507 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022320 Css NA 0.3203 mg/L PBTK NA 50% Rat Human +DTXSID3022320 Css NA 1.703 mg/L PBTK NA 95% Rat Human +DTXSID3022326 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022326 Fup 0.205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022326 Vd NA 0.3449 L/kg 1compartment NA NA Human Human DTXSID3022326 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3022326 TK.Half.Life NA 11.37 hours 1compartment NA NA Human Human -DTXSID3022326 Css NA 2.678 mg/L 3compartmentss NA 50% Human Human -DTXSID3022326 Css NA 10.44 mg/L 3compartmentss NA 95% Human Human -DTXSID3022326 Css NA 1.856 mg/L PBTK NA 50% Human Human -DTXSID3022326 Css NA 6.498 mg/L PBTK NA 95% Human Human -DTXSID3022326 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022326 Fup NA 0.2847 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022326 Vd NA 0.5033 L/kg 1compartment NA NA Rat Human +DTXSID3022326 TK.Half.Life NA 10.89 hours 1compartment NA NA Human Human +DTXSID3022326 Css NA 3.327 mg/L 3compartmentss NA 50% Human Human +DTXSID3022326 Css NA 12.34 mg/L 3compartmentss NA 95% Human Human +DTXSID3022326 Css NA 2.166 mg/L PBTK NA 50% Human Human +DTXSID3022326 Css NA 7.494 mg/L PBTK NA 95% Human Human +DTXSID3022326 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022326 Fup 0.205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022326 Vd NA 0.3592 L/kg 1compartment NA NA Rat Human DTXSID3022326 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022326 TK.Half.Life NA 3.898 hours 1compartment NA NA Rat Human -DTXSID3022326 Css NA 0.7466 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022326 Css NA 2.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022326 Css NA 0.4896 mg/L PBTK NA 50% Rat Human -DTXSID3022326 Css NA 1.426 mg/L PBTK NA 95% Rat Human +DTXSID3022326 TK.Half.Life NA 3.864 hours 1compartment NA NA Rat Human +DTXSID3022326 Css NA 0.0598 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022326 Css NA 0.3487 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022326 Css NA 0.03734 mg/L PBTK NA 50% Rat Human +DTXSID3022326 Css NA 0.2063 mg/L PBTK NA 95% Rat Human +DTXSID3022328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022328 Fup 0.0154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022328 Vd NA 1.168 L/kg 1compartment NA NA Human Human +DTXSID3022328 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3022328 TK.Half.Life NA 12.71 hours 1compartment NA NA Human Human +DTXSID3022328 Css NA 1.674 mg/L 3compartmentss NA 50% Human Human +DTXSID3022328 Css NA 16.01 mg/L 3compartmentss NA 95% Human Human +DTXSID3022328 Css NA 1.024 mg/L PBTK NA 50% Human Human +DTXSID3022328 Css NA 9.448 mg/L PBTK NA 95% Human Human +DTXSID3022328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022328 Fup 0.0154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022328 Vd NA 0.8627 L/kg 1compartment NA NA Rat Human +DTXSID3022328 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022328 TK.Half.Life NA 5.34 hours 1compartment NA NA Rat Human +DTXSID3022328 Css NA 0.1448 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022328 Css NA 1.191 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022328 Css NA 0.086 mg/L PBTK NA 50% Rat Human +DTXSID3022328 Css NA 0.6798 mg/L PBTK NA 95% Rat Human DTXSID3022370 Clint 33.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3022370 Fup 0.02311 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3022370 Vd NA 2.307 L/kg 1compartment NA NA Human Human DTXSID3022370 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID3022370 TK.Half.Life NA 15.13 hours 1compartment NA NA Human Human -DTXSID3022370 Css NA 0.8544 mg/L 3compartmentss NA 50% Human Human -DTXSID3022370 Css NA 7.116 mg/L 3compartmentss NA 95% Human Human -DTXSID3022370 Css NA 0.6076 mg/L PBTK NA 50% Human Human -DTXSID3022370 Css NA 4.695 mg/L PBTK NA 95% Human Human +DTXSID3022370 Css NA 0.8361 mg/L 3compartmentss NA 50% Human Human +DTXSID3022370 Css NA 7.291 mg/L 3compartmentss NA 95% Human Human +DTXSID3022370 Css NA 0.5946 mg/L PBTK NA 50% Human Human +DTXSID3022370 Css NA 4.778 mg/L PBTK NA 95% Human Human DTXSID3022370 Clint 33.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3022370 Fup 0.02311 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3022370 Vd NA 1.778 L/kg 1compartment NA NA Rat Human DTXSID3022370 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3022370 TK.Half.Life NA 4.718 hours 1compartment NA NA Rat Human -DTXSID3022370 Css NA 0.4742 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022370 Css NA 3.217 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022370 Css NA 0.3208 mg/L PBTK NA 50% Rat Human -DTXSID3022370 Css NA 1.994 mg/L PBTK NA 95% Rat Human -DTXSID3022401 Clint NA 193.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022401 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022401 Vd NA 68.85 L/kg 1compartment NA NA Human Human +DTXSID3022370 Css NA 0.1073 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022370 Css NA 0.7645 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022370 Css NA 0.07514 mg/L PBTK NA 50% Rat Human +DTXSID3022370 Css NA 0.5021 mg/L PBTK NA 95% Rat Human +DTXSID3022401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022401 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022401 Vd NA 6.092 L/kg 1compartment NA NA Human Human DTXSID3022401 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022401 TK.Half.Life NA 11.9 hours 1compartment NA NA Human Human -DTXSID3022401 Css NA 0.001754 mg/L 3compartmentss NA 50% Human Human -DTXSID3022401 Css NA 0.03882 mg/L 3compartmentss NA 95% Human Human -DTXSID3022401 Css NA 0.01194 mg/L PBTK NA 50% Human Human -DTXSID3022401 Css NA 0.1061 mg/L PBTK NA 95% Human Human -DTXSID3022401 Clint NA 193.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022401 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022401 Vd NA 58.85 L/kg 1compartment NA NA Rat Human +DTXSID3022401 TK.Half.Life NA 6.353 hours 1compartment NA NA Human Human +DTXSID3022401 Css NA 0.04962 mg/L 3compartmentss NA 50% Human Human +DTXSID3022401 Css NA 0.4517 mg/L 3compartmentss NA 95% Human Human +DTXSID3022401 Css NA 0.04764 mg/L PBTK NA 50% Human Human +DTXSID3022401 Css NA 0.3725 mg/L PBTK NA 95% Human Human +DTXSID3022401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022401 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022401 Vd NA 4.941 L/kg 1compartment NA NA Rat Human DTXSID3022401 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022401 TK.Half.Life NA 4.944 hours 1compartment NA NA Rat Human -DTXSID3022401 Css NA 0.0008902 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022401 Css NA 0.01828 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022401 Css NA 0.006398 mg/L PBTK NA 50% Rat Human -DTXSID3022401 Css NA 0.04867 mg/L PBTK NA 95% Rat Human -DTXSID3022403 Clint NA 61.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022403 Fup NA 0.0454 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022403 Vd NA 1.106 L/kg 1compartment NA NA Human Human +DTXSID3022401 TK.Half.Life NA 2.012 hours 1compartment NA NA Rat Human +DTXSID3022401 Css NA 0.006259 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022401 Css NA 0.04724 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022401 Css NA 0.006185 mg/L PBTK NA 50% Rat Human +DTXSID3022401 Css NA 0.04111 mg/L PBTK NA 95% Rat Human +DTXSID3022403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022403 Fup 0.0774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022403 Vd NA 0.9036 L/kg 1compartment NA NA Human Human DTXSID3022403 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022403 TK.Half.Life NA 2.524 hours 1compartment NA NA Human Human -DTXSID3022403 Css NA 0.231 mg/L 3compartmentss NA 50% Human Human -DTXSID3022403 Css NA 1.617 mg/L 3compartmentss NA 95% Human Human -DTXSID3022403 Css NA 0.1452 mg/L PBTK NA 50% Human Human -DTXSID3022403 Css NA 0.9798 mg/L PBTK NA 95% Human Human -DTXSID3022403 Clint NA 61.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022403 Fup NA 0.0454 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022403 Vd NA 0.8377 L/kg 1compartment NA NA Rat Human +DTXSID3022403 TK.Half.Life NA 2.821 hours 1compartment NA NA Human Human +DTXSID3022403 Css NA 0.3744 mg/L 3compartmentss NA 50% Human Human +DTXSID3022403 Css NA 2.798 mg/L 3compartmentss NA 95% Human Human +DTXSID3022403 Css NA 0.2364 mg/L PBTK NA 50% Human Human +DTXSID3022403 Css NA 1.713 mg/L PBTK NA 95% Human Human +DTXSID3022403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022403 Fup 0.0774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022403 Vd NA 0.708 L/kg 1compartment NA NA Rat Human DTXSID3022403 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022403 TK.Half.Life NA 1.028 hours 1compartment NA NA Rat Human -DTXSID3022403 Css NA 0.131 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022403 Css NA 0.7586 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022403 Css NA 0.07709 mg/L PBTK NA 50% Rat Human -DTXSID3022403 Css NA 0.4399 mg/L PBTK NA 95% Rat Human +DTXSID3022403 TK.Half.Life NA 1.263 hours 1compartment NA NA Rat Human +DTXSID3022403 Css NA 0.04864 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022403 Css NA 0.2919 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022403 Css NA 0.02991 mg/L PBTK NA 50% Rat Human +DTXSID3022403 Css NA 0.1722 mg/L PBTK NA 95% Rat Human DTXSID3022405 Clint 15.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3022405 Fup 0.00952 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3022405 Vd NA 1.462 L/kg 1compartment NA NA Human Human DTXSID3022405 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID3022405 TK.Half.Life NA 30.59 hours 1compartment NA NA Human Human -DTXSID3022405 Css NA 2.222 mg/L 3compartmentss NA 50% Human Human -DTXSID3022405 Css NA 15.51 mg/L 3compartmentss NA 95% Human Human -DTXSID3022405 Css NA 1.411 mg/L PBTK NA 50% Human Human -DTXSID3022405 Css NA 9.393 mg/L PBTK NA 95% Human Human +DTXSID3022405 Css NA 2.138 mg/L 3compartmentss NA 50% Human Human +DTXSID3022405 Css NA 14.7 mg/L 3compartmentss NA 95% Human Human +DTXSID3022405 Css NA 1.366 mg/L PBTK NA 50% Human Human +DTXSID3022405 Css NA 9.127 mg/L PBTK NA 95% Human Human DTXSID3022405 Clint 15.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3022405 Fup 0.00952 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3022405 Vd NA 1.078 L/kg 1compartment NA NA Rat Human +DTXSID3022405 Vd 0.97 1.078 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID3022405 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3022405 TK.Half.Life NA 11.89 hours 1compartment NA NA Rat Human -DTXSID3022405 Css NA 1.235 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022405 Css NA 6.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022405 Css NA 0.7393 mg/L PBTK NA 50% Rat Human -DTXSID3022405 Css NA 3.824 mg/L PBTK NA 95% Rat Human +DTXSID3022405 TK.Half.Life 0.075 11.89 hours 1compartment National Toxicology Program NA Rat Human +DTXSID3022405 Css 0.0047 0.2772 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID3022405 Css 0.0047 1.501 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID3022405 Css 0.0047 0.1719 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID3022405 Css 0.0047 0.9122 mg/L PBTK National Toxicology Program 95% Rat Human DTXSID3022409 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3022409 Fup 0.0576 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3022409 Vd NA 0.2053 L/kg 1compartment NA NA Human Human -DTXSID3022409 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3022409 TK.Half.Life NA 23.07 hours 1compartment NA NA Human Human -DTXSID3022409 Css NA 14.47 mg/L 3compartmentss NA 50% Human Human -DTXSID3022409 Css NA 58.14 mg/L 3compartmentss NA 95% Human Human -DTXSID3022409 Css NA 8.616 mg/L PBTK NA 50% Human Human -DTXSID3022409 Css NA 33.65 mg/L PBTK NA 95% Human Human +DTXSID3022409 Vd NA 0.2524 L/kg 1compartment NA NA Human Human +DTXSID3022409 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3022409 TK.Half.Life NA 28.41 hours 1compartment NA NA Human Human +DTXSID3022409 Css NA 14 mg/L 3compartmentss NA 50% Human Human +DTXSID3022409 Css NA 55.78 mg/L 3compartmentss NA 95% Human Human +DTXSID3022409 Css NA 8.406 mg/L PBTK NA 50% Human Human +DTXSID3022409 Css NA 32.62 mg/L PBTK NA 95% Human Human DTXSID3022409 Clint 33.1 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID3022409 Fup 0.0711 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID3022409 Vd NA 0.2153 L/kg 1compartment NA NA Rat Rat +DTXSID3022409 Vd NA 0.2554 L/kg 1compartment NA NA Rat Rat DTXSID3022409 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID3022409 TK.Half.Life NA 0.3279 hours 1compartment NA NA Rat Rat -DTXSID3022409 Css NA 0.1605 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3022409 Css NA 0.8924 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3022409 Css NA 0.08953 mg/L PBTK NA 50% Rat Rat -DTXSID3022409 Css NA 0.4937 mg/L PBTK NA 95% Rat Rat +DTXSID3022409 TK.Half.Life NA 0.3851 hours 1compartment NA NA Rat Rat +DTXSID3022409 Css NA 0.03542 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3022409 Css NA 0.2101 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3022409 Css NA 0.02072 mg/L PBTK NA 50% Rat Rat +DTXSID3022409 Css NA 0.1206 mg/L PBTK NA 95% Rat Rat DTXSID3022455 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3022455 Fup 0.656 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3022455 Vd NA 1.512 L/kg 1compartment NA NA Human Human +DTXSID3022455 Vd NA 1.522 L/kg 1compartment NA NA Human Human DTXSID3022455 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3022455 TK.Half.Life NA 17.62 hours 1compartment NA NA Human Human -DTXSID3022455 Css NA 1.162 mg/L 3compartmentss NA 50% Human Human -DTXSID3022455 Css NA 7.659 mg/L 3compartmentss NA 95% Human Human -DTXSID3022455 Css NA 1.034 mg/L PBTK NA 50% Human Human -DTXSID3022455 Css NA 5.024 mg/L PBTK NA 95% Human Human +DTXSID3022455 TK.Half.Life NA 17.8 hours 1compartment NA NA Human Human +DTXSID3022455 Css NA 1.135 mg/L 3compartmentss NA 50% Human Human +DTXSID3022455 Css NA 7.488 mg/L 3compartmentss NA 95% Human Human +DTXSID3022455 Css NA 1.015 mg/L PBTK NA 50% Human Human +DTXSID3022455 Css NA 4.984 mg/L PBTK NA 95% Human Human DTXSID3022455 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3022455 Fup 0.656 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID3022455 Vd NA 1.314 L/kg 1compartment NA NA Rat Human +DTXSID3022455 Vd NA 1.321 L/kg 1compartment NA NA Rat Human DTXSID3022455 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022455 TK.Half.Life NA 4.606 hours 1compartment NA NA Rat Human -DTXSID3022455 Css NA 0.3064 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022455 Css NA 1.922 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022455 Css NA 0.2648 mg/L PBTK NA 50% Rat Human -DTXSID3022455 Css NA 1.178 mg/L PBTK NA 95% Rat Human +DTXSID3022455 TK.Half.Life NA 4.636 hours 1compartment NA NA Rat Human +DTXSID3022455 Css NA 0.06963 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022455 Css NA 0.43 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022455 Css NA 0.0622 mg/L PBTK NA 50% Rat Human +DTXSID3022455 Css NA 0.2734 mg/L PBTK NA 95% Rat Human DTXSID3022536 Clint 27.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3022536 Fup 0.0231 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3022536 Vd NA 1.907 L/kg 1compartment NA NA Human Human +DTXSID3022536 Vd NA 1.921 L/kg 1compartment NA NA Human Human DTXSID3022536 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3022536 TK.Half.Life NA 14.11 hours 1compartment NA NA Human Human -DTXSID3022536 Css NA 0.8591 mg/L 3compartmentss NA 50% Human Human -DTXSID3022536 Css NA 5.603 mg/L 3compartmentss NA 95% Human Human -DTXSID3022536 Css NA 0.5618 mg/L PBTK NA 50% Human Human -DTXSID3022536 Css NA 3.521 mg/L PBTK NA 95% Human Human +DTXSID3022536 TK.Half.Life NA 14.28 hours 1compartment NA NA Human Human +DTXSID3022536 Css NA 0.836 mg/L 3compartmentss NA 50% Human Human +DTXSID3022536 Css NA 5.757 mg/L 3compartmentss NA 95% Human Human +DTXSID3022536 Css NA 0.5429 mg/L PBTK NA 50% Human Human +DTXSID3022536 Css NA 3.635 mg/L PBTK NA 95% Human Human DTXSID3022536 Clint 27.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3022536 Fup 0.0231 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3022536 Vd NA 1.418 L/kg 1compartment NA NA Rat Human +DTXSID3022536 Vd NA 1.428 L/kg 1compartment NA NA Rat Human DTXSID3022536 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022536 TK.Half.Life NA 4.735 hours 1compartment NA NA Rat Human -DTXSID3022536 Css NA 0.4798 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022536 Css NA 2.542 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022536 Css NA 0.296 mg/L PBTK NA 50% Rat Human -DTXSID3022536 Css NA 1.53 mg/L PBTK NA 95% Rat Human -DTXSID3022582 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022582 Fup NA 0.9072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022582 Vd NA 3.155 L/kg 1compartment NA NA Human Human -DTXSID3022582 Days.Css NA 138 Days PBTK NA NA Human Human -DTXSID3022582 TK.Half.Life NA 576.7 hours 1compartment NA NA Human Human -DTXSID3022582 Css NA 19.75 mg/L 3compartmentss NA 50% Human Human -DTXSID3022582 Css NA 57.66 mg/L 3compartmentss NA 95% Human Human -DTXSID3022582 Css NA 14.65 mg/L PBTK NA 50% Human Human -DTXSID3022582 Css NA 38.96 mg/L PBTK NA 95% Human Human -DTXSID3022582 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022582 Fup NA 0.9072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022582 Vd NA 2.402 L/kg 1compartment NA NA Rat Human -DTXSID3022582 Days.Css NA 34 Days PBTK NA NA Rat Human -DTXSID3022582 TK.Half.Life NA 40.11 hours 1compartment NA NA Rat Human -DTXSID3022582 Css NA 5.349 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022582 Css NA 12.82 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022582 Css NA 3.828 mg/L PBTK NA 50% Rat Human -DTXSID3022582 Css NA 8.003 mg/L PBTK NA 95% Rat Human -DTXSID3022584 Clint NA 1.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3022536 TK.Half.Life NA 4.761 hours 1compartment NA NA Rat Human +DTXSID3022536 Css NA 0.1074 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022536 Css NA 0.6022 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022536 Css NA 0.06874 mg/L PBTK NA 50% Rat Human +DTXSID3022536 Css NA 0.3805 mg/L PBTK NA 95% Rat Human +DTXSID3022582 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022582 Fup 0.0485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022582 Vd NA 1.708 L/kg 1compartment NA NA Human Human +DTXSID3022582 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022582 TK.Half.Life NA 8.573 hours 1compartment NA NA Human Human +DTXSID3022582 Css NA 0.6637 mg/L 3compartmentss NA 50% Human Human +DTXSID3022582 Css NA 5.23 mg/L 3compartmentss NA 95% Human Human +DTXSID3022582 Css NA 0.4299 mg/L PBTK NA 50% Human Human +DTXSID3022582 Css NA 3.239 mg/L PBTK NA 95% Human Human +DTXSID3022582 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022582 Fup 0.0485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022582 Vd NA 1.289 L/kg 1compartment NA NA Rat Human +DTXSID3022582 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022582 TK.Half.Life NA 3.145 hours 1compartment NA NA Rat Human +DTXSID3022582 Css NA 0.08663 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022582 Css NA 0.5131 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022582 Css NA 0.05486 mg/L PBTK NA 50% Rat Human +DTXSID3022582 Css NA 0.3089 mg/L PBTK NA 95% Rat Human +DTXSID3022584 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3022584 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3022584 Vd NA 1.219 L/kg 1compartment NA NA Human Human -DTXSID3022584 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022584 TK.Half.Life NA 2.643 hours 1compartment NA NA Human Human -DTXSID3022584 Css NA 0.2086 mg/L 3compartmentss NA 50% Human Human -DTXSID3022584 Css NA 1.069 mg/L 3compartmentss NA 95% Human Human -DTXSID3022584 Css NA 0.1853 mg/L PBTK NA 50% Human Human -DTXSID3022584 Css NA 0.7933 mg/L PBTK NA 95% Human Human -DTXSID3022584 Clint NA 1.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3022584 Vd NA 1.373 L/kg 1compartment NA NA Human Human +DTXSID3022584 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3022584 TK.Half.Life NA 10.86 hours 1compartment NA NA Human Human +DTXSID3022584 Css NA 0.8104 mg/L 3compartmentss NA 50% Human Human +DTXSID3022584 Css NA 3.384 mg/L 3compartmentss NA 95% Human Human +DTXSID3022584 Css NA 0.7457 mg/L PBTK NA 50% Human Human +DTXSID3022584 Css NA 2.424 mg/L PBTK NA 95% Human Human +DTXSID3022584 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3022584 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3022584 Vd NA 1.137 L/kg 1compartment NA NA Rat Human +DTXSID3022584 Vd NA 1.252 L/kg 1compartment NA NA Rat Human DTXSID3022584 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022584 TK.Half.Life NA 1.223 hours 1compartment NA NA Rat Human -DTXSID3022584 Css NA 0.08762 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022584 Css NA 0.3588 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022584 Css NA 0.07758 mg/L PBTK NA 50% Rat Human -DTXSID3022584 Css NA 0.2429 mg/L PBTK NA 95% Rat Human +DTXSID3022584 TK.Half.Life NA 3.141 hours 1compartment NA NA Rat Human +DTXSID3022584 Css NA 0.04832 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022584 Css NA 0.1796 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022584 Css NA 0.04518 mg/L PBTK NA 50% Rat Human +DTXSID3022584 Css NA 0.1249 mg/L PBTK NA 95% Rat Human DTXSID3022586 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3022586 Fup 0.88 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3022586 Vd NA 1.012 L/kg 1compartment NA NA Human Human +DTXSID3022586 Vd NA 0.8101 L/kg 1compartment NA NA Human Human DTXSID3022586 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022586 TK.Half.Life NA 7.441 hours 1compartment NA NA Human Human -DTXSID3022586 Css NA 0.8992 mg/L 3compartmentss NA 50% Human Human -DTXSID3022586 Css NA 5.092 mg/L 3compartmentss NA 95% Human Human -DTXSID3022586 Css NA 0.7752 mg/L PBTK NA 50% Human Human -DTXSID3022586 Css NA 3.384 mg/L PBTK NA 95% Human Human +DTXSID3022586 TK.Half.Life NA 5.955 hours 1compartment NA NA Human Human +DTXSID3022586 Css NA 0.7919 mg/L 3compartmentss NA 50% Human Human +DTXSID3022586 Css NA 4.42 mg/L 3compartmentss NA 95% Human Human +DTXSID3022586 Css NA 0.6619 mg/L PBTK NA 50% Human Human +DTXSID3022586 Css NA 2.875 mg/L PBTK NA 95% Human Human DTXSID3022586 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3022586 Fup 0.88 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3022586 Vd NA 1.048 L/kg 1compartment NA NA Rat Human +DTXSID3022586 Vd NA 0.8688 L/kg 1compartment NA NA Rat Human DTXSID3022586 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022586 TK.Half.Life NA 2.626 hours 1compartment NA NA Rat Human -DTXSID3022586 Css NA 0.2268 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022586 Css NA 1.357 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022586 Css NA 0.1909 mg/L PBTK NA 50% Rat Human -DTXSID3022586 Css NA 0.8273 mg/L PBTK NA 95% Rat Human +DTXSID3022586 TK.Half.Life NA 2.176 hours 1compartment NA NA Rat Human +DTXSID3022586 Css NA 0.01458 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022586 Css NA 0.1077 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022586 Css NA 0.01165 mg/L PBTK NA 50% Rat Human +DTXSID3022586 Css NA 0.06988 mg/L PBTK NA 95% Rat Human DTXSID3022588 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID3022588 Fup 0.75 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human -DTXSID3022588 Vd NA 0.7338 L/kg 1compartment NA NA Human Human +DTXSID3022588 Vd NA 0.5966 L/kg 1compartment NA NA Human Human DTXSID3022588 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022588 TK.Half.Life NA 6.353 hours 1compartment NA NA Human Human -DTXSID3022588 Css NA 1.038 mg/L 3compartmentss NA 50% Human Human -DTXSID3022588 Css NA 6.255 mg/L 3compartmentss NA 95% Human Human -DTXSID3022588 Css NA 0.8438 mg/L PBTK NA 50% Human Human -DTXSID3022588 Css NA 4.052 mg/L PBTK NA 95% Human Human +DTXSID3022588 TK.Half.Life NA 5.15 hours 1compartment NA NA Human Human +DTXSID3022588 Css NA 0.5868 mg/L 3compartmentss NA 50% Human Human +DTXSID3022588 Css NA 3.685 mg/L 3compartmentss NA 95% Human Human +DTXSID3022588 Css NA 0.4614 mg/L PBTK NA 50% Human Human +DTXSID3022588 Css NA 2.336 mg/L PBTK NA 95% Human Human DTXSID3022588 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID3022588 Fup 0.75 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human -DTXSID3022588 Vd NA 0.7455 L/kg 1compartment NA NA Rat Human +DTXSID3022588 Vd NA 0.6293 L/kg 1compartment NA NA Rat Human DTXSID3022588 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022588 TK.Half.Life NA 2.194 hours 1compartment NA NA Rat Human -DTXSID3022588 Css NA 0.2707 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022588 Css NA 1.66 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022588 Css NA 0.2127 mg/L PBTK NA 50% Rat Human -DTXSID3022588 Css NA 0.9847 mg/L PBTK NA 95% Rat Human -DTXSID3022611 Clint NA 0.1652 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022611 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022611 Vd NA 0.2049 L/kg 1compartment NA NA Human Human -DTXSID3022611 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID3022611 TK.Half.Life NA 60.43 hours 1compartment NA NA Human Human -DTXSID3022611 Css NA 49.29 mg/L 3compartmentss NA 50% Human Human -DTXSID3022611 Css NA 315.1 mg/L 3compartmentss NA 95% Human Human -DTXSID3022611 Css NA 29.13 mg/L PBTK NA 50% Human Human -DTXSID3022611 Css NA 182 mg/L PBTK NA 95% Human Human -DTXSID3022611 Clint NA 0.1652 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022611 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022611 Vd NA 0.1971 L/kg 1compartment NA NA Rat Human -DTXSID3022611 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3022611 TK.Half.Life NA 22.28 hours 1compartment NA NA Rat Human -DTXSID3022611 Css NA 16.15 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022611 Css NA 91.42 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022611 Css NA 8.866 mg/L PBTK NA 50% Rat Human -DTXSID3022611 Css NA 49.5 mg/L PBTK NA 95% Rat Human -DTXSID3022617 Clint NA 0.7444 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022617 Fup NA 0.7498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022617 Vd NA 2.049 L/kg 1compartment NA NA Human Human -DTXSID3022617 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022617 TK.Half.Life NA 8.248 hours 1compartment NA NA Human Human -DTXSID3022617 Css NA 0.3781 mg/L 3compartmentss NA 50% Human Human -DTXSID3022617 Css NA 2.676 mg/L 3compartmentss NA 95% Human Human -DTXSID3022617 Css NA 0.3806 mg/L PBTK NA 50% Human Human -DTXSID3022617 Css NA 1.886 mg/L PBTK NA 95% Human Human -DTXSID3022617 Clint NA 0.7444 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022617 Fup NA 0.7498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022617 Vd NA 2.076 L/kg 1compartment NA NA Rat Human +DTXSID3022588 TK.Half.Life NA 1.85 hours 1compartment NA NA Rat Human +DTXSID3022588 Css NA 0.003024 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022588 Css NA 0.02086 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022588 Css NA 0.002298 mg/L PBTK NA 50% Rat Human +DTXSID3022588 Css NA 0.0126 mg/L PBTK NA 95% Rat Human +DTXSID30225901 Clint 38.9 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30225901 Fup 0.0239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30225901 Vd NA 0.4299 L/kg 1compartment NA NA Human Human +DTXSID30225901 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30225901 TK.Half.Life NA 2.094 hours 1compartment NA NA Human Human +DTXSID30225901 Css NA 0.699 mg/L 3compartmentss NA 50% Human Human +DTXSID30225901 Css NA 7.359 mg/L 3compartmentss NA 95% Human Human +DTXSID30225901 Css NA 0.4378 mg/L PBTK NA 50% Human Human +DTXSID30225901 Css NA 4.374 mg/L PBTK NA 95% Human Human +DTXSID30225901 Clint 38.9 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30225901 Fup 0.0239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30225901 Vd NA 0.3999 L/kg 1compartment NA NA Rat Human +DTXSID30225901 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30225901 TK.Half.Life NA 1.248 hours 1compartment NA NA Rat Human +DTXSID30225901 Css NA 0.09345 mg/L 3compartmentss NA 50% Rat Human +DTXSID30225901 Css NA 0.8278 mg/L 3compartmentss NA 95% Rat Human +DTXSID30225901 Css NA 0.05674 mg/L PBTK NA 50% Rat Human +DTXSID30225901 Css NA 0.4777 mg/L PBTK NA 95% Rat Human +DTXSID3022611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022611 Fup 0.0535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022611 Vd NA 1.309 L/kg 1compartment NA NA Human Human +DTXSID3022611 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022611 TK.Half.Life NA 5.64 hours 1compartment NA NA Human Human +DTXSID3022611 Css NA 0.5646 mg/L 3compartmentss NA 50% Human Human +DTXSID3022611 Css NA 4.476 mg/L 3compartmentss NA 95% Human Human +DTXSID3022611 Css NA 0.3612 mg/L PBTK NA 50% Human Human +DTXSID3022611 Css NA 2.704 mg/L PBTK NA 95% Human Human +DTXSID3022611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022611 Fup 0.0535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022611 Vd NA 0.9897 L/kg 1compartment NA NA Rat Human +DTXSID3022611 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022611 TK.Half.Life NA 2.291 hours 1compartment NA NA Rat Human +DTXSID3022611 Css NA 0.07399 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022611 Css NA 0.4562 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022611 Css NA 0.04572 mg/L PBTK NA 50% Rat Human +DTXSID3022611 Css NA 0.269 mg/L PBTK NA 95% Rat Human +DTXSID3022613 Clint 52 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID3022613 Fup 0.562 NA NA Williamson 2020 NA Human Human +DTXSID3022613 Vd NA 2.811 L/kg 1compartment NA NA Human Human +DTXSID3022613 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022613 TK.Half.Life NA 3.169 hours 1compartment NA NA Human Human +DTXSID3022613 Css NA 0.03937 mg/L 3compartmentss NA 50% Human Human +DTXSID3022613 Css NA 0.3196 mg/L 3compartmentss NA 95% Human Human +DTXSID3022613 Css NA 0.03067 mg/L PBTK NA 50% Human Human +DTXSID3022613 Css NA 0.2362 mg/L PBTK NA 95% Human Human +DTXSID3022613 Clint 52 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID3022613 Fup 0.562 NA NA Williamson 2020 NA Rat Human +DTXSID3022613 Vd NA 2.173 L/kg 1compartment NA NA Rat Human +DTXSID3022613 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022613 TK.Half.Life NA 0.9051 hours 1compartment NA NA Rat Human +DTXSID3022613 Css NA 0.00144 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022613 Css NA 0.01335 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022613 Css NA 0.001106 mg/L PBTK NA 50% Rat Human +DTXSID3022613 Css NA 0.009231 mg/L PBTK NA 95% Rat Human +DTXSID3022617 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022617 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022617 Vd NA 2.113 L/kg 1compartment NA NA Human Human +DTXSID3022617 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3022617 TK.Half.Life NA 17.52 hours 1compartment NA NA Human Human +DTXSID3022617 Css NA 0.7834 mg/L 3compartmentss NA 50% Human Human +DTXSID3022617 Css NA 5.709 mg/L 3compartmentss NA 95% Human Human +DTXSID3022617 Css NA 0.7983 mg/L PBTK NA 50% Human Human +DTXSID3022617 Css NA 3.952 mg/L PBTK NA 95% Human Human +DTXSID3022617 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022617 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022617 Vd NA 2.141 L/kg 1compartment NA NA Rat Human DTXSID3022617 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022617 TK.Half.Life NA 3.881 hours 1compartment NA NA Rat Human -DTXSID3022617 Css NA 0.1328 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022617 Css NA 1.016 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022617 Css NA 0.1341 mg/L PBTK NA 50% Rat Human -DTXSID3022617 Css NA 0.6487 mg/L PBTK NA 95% Rat Human +DTXSID3022617 TK.Half.Life NA 6.027 hours 1compartment NA NA Rat Human +DTXSID3022617 Css NA 0.04531 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022617 Css NA 0.3142 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022617 Css NA 0.04756 mg/L PBTK NA 50% Rat Human +DTXSID3022617 Css NA 0.2107 mg/L PBTK NA 95% Rat Human DTXSID3022663 Clint 2 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID3022663 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3022663 Vd NA 2.103 L/kg 1compartment NA NA Human Human -DTXSID3022663 Days.Css NA 223 Days PBTK NA NA Human Human -DTXSID3022663 TK.Half.Life NA 878.2 hours 1compartment NA NA Human Human -DTXSID3022663 Css NA 68.38 mg/L 3compartmentss NA 50% Human Human -DTXSID3022663 Css NA 450.8 mg/L 3compartmentss NA 95% Human Human -DTXSID3022663 Css NA 42.55 mg/L PBTK NA 50% Human Human -DTXSID3022663 Css NA 272.7 mg/L PBTK NA 95% Human Human +DTXSID3022663 Vd NA 2.045 L/kg 1compartment NA NA Human Human +DTXSID3022663 Days.Css NA 221 Days PBTK NA NA Human Human +DTXSID3022663 TK.Half.Life NA 868.6 hours 1compartment NA NA Human Human +DTXSID3022663 Css NA 64.12 mg/L 3compartmentss NA 50% Human Human +DTXSID3022663 Css NA 423.1 mg/L 3compartmentss NA 95% Human Human +DTXSID3022663 Css NA 42.96 mg/L PBTK NA 50% Human Human +DTXSID3022663 Css NA 283.5 mg/L PBTK NA 95% Human Human DTXSID3022663 Clint 2 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID3022663 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3022663 Vd NA 1.555 L/kg 1compartment NA NA Rat Human -DTXSID3022663 Days.Css NA 113 Days PBTK NA NA Rat Human -DTXSID3022663 TK.Half.Life NA 260.4 hours 1compartment NA NA Rat Human -DTXSID3022663 Css NA 38.52 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022663 Css NA 188.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022663 Css NA 22.52 mg/L PBTK NA 50% Rat Human -DTXSID3022663 Css NA 106.4 mg/L PBTK NA 95% Rat Human -DTXSID3022667 Clint NA 3.814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3022663 Vd NA 1.511 L/kg 1compartment NA NA Rat Human +DTXSID3022663 Days.Css NA 112 Days PBTK NA NA Rat Human +DTXSID3022663 TK.Half.Life NA 264.4 hours 1compartment NA NA Rat Human +DTXSID3022663 Css NA 7.78 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022663 Css NA 37.38 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022663 Css NA 5.398 mg/L PBTK NA 50% Rat Human +DTXSID3022663 Css NA 25.94 mg/L PBTK NA 95% Rat Human +DTXSID3022667 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3022667 Fup 0.36 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3022667 Vd NA 1.129 L/kg 1compartment NA NA Human Human -DTXSID3022667 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022667 TK.Half.Life NA 3.62 hours 1compartment NA NA Human Human -DTXSID3022667 Css NA 0.3039 mg/L 3compartmentss NA 50% Human Human -DTXSID3022667 Css NA 1.752 mg/L 3compartmentss NA 95% Human Human -DTXSID3022667 Css NA 0.2304 mg/L PBTK NA 50% Human Human -DTXSID3022667 Css NA 1.192 mg/L PBTK NA 95% Human Human -DTXSID3022667 Clint NA 3.814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3022667 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3022667 TK.Half.Life NA 22.94 hours 1compartment NA NA Human Human +DTXSID3022667 Css NA 2.125 mg/L 3compartmentss NA 50% Human Human +DTXSID3022667 Css NA 8.738 mg/L 3compartmentss NA 95% Human Human +DTXSID3022667 Css NA 1.618 mg/L PBTK NA 50% Human Human +DTXSID3022667 Css NA 5.685 mg/L PBTK NA 95% Human Human +DTXSID3022667 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3022667 Fup 0.36 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3022667 Vd NA 0.9488 L/kg 1compartment NA NA Rat Human DTXSID3022667 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022667 TK.Half.Life NA 1.594 hours 1compartment NA NA Rat Human -DTXSID3022667 Css NA 0.148 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022667 Css NA 0.6372 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022667 Css NA 0.1083 mg/L PBTK NA 50% Rat Human -DTXSID3022667 Css NA 0.397 mg/L PBTK NA 95% Rat Human -DTXSID3022742 Clint NA 2.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022742 Fup NA 0.1294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022742 Vd NA 0.3968 L/kg 1compartment NA NA Human Human -DTXSID3022742 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022742 TK.Half.Life NA 4.116 hours 1compartment NA NA Human Human -DTXSID3022742 Css NA 1.542 mg/L 3compartmentss NA 50% Human Human -DTXSID3022742 Css NA 9.257 mg/L 3compartmentss NA 95% Human Human -DTXSID3022742 Css NA 0.9687 mg/L PBTK NA 50% Human Human -DTXSID3022742 Css NA 5.465 mg/L PBTK NA 95% Human Human -DTXSID3022742 Clint NA 2.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022742 Fup NA 0.1294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022742 Vd NA 0.3826 L/kg 1compartment NA NA Rat Human +DTXSID3022667 TK.Half.Life NA 5.996 hours 1compartment NA NA Rat Human +DTXSID3022667 Css NA 0.1355 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022667 Css NA 0.4735 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022667 Css NA 0.1024 mg/L PBTK NA 50% Rat Human +DTXSID3022667 Css NA 0.2962 mg/L PBTK NA 95% Rat Human +DTXSID3022742 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022742 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022742 Vd NA 0.3941 L/kg 1compartment NA NA Human Human +DTXSID3022742 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3022742 TK.Half.Life NA 14.5 hours 1compartment NA NA Human Human +DTXSID3022742 Css NA 2.521 mg/L 3compartmentss NA 50% Human Human +DTXSID3022742 Css NA 10.64 mg/L 3compartmentss NA 95% Human Human +DTXSID3022742 Css NA 1.634 mg/L PBTK NA 50% Human Human +DTXSID3022742 Css NA 6.392 mg/L PBTK NA 95% Human Human +DTXSID3022742 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022742 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022742 Vd NA 0.3708 L/kg 1compartment NA NA Rat Human DTXSID3022742 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022742 TK.Half.Life NA 2.242 hours 1compartment NA NA Rat Human -DTXSID3022742 Css NA 0.7397 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022742 Css NA 3.322 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022742 Css NA 0.4358 mg/L PBTK NA 50% Rat Human -DTXSID3022742 Css NA 1.85 mg/L PBTK NA 95% Rat Human -DTXSID3022748 Clint NA 0.5075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022748 Fup NA 0.546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022748 Vd NA 0.6046 L/kg 1compartment NA NA Human Human +DTXSID3022742 TK.Half.Life NA 4.627 hours 1compartment NA NA Rat Human +DTXSID3022742 Css NA 0.01374 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022742 Css NA 0.05529 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022742 Css NA 0.008396 mg/L PBTK NA 50% Rat Human +DTXSID3022742 Css NA 0.032 mg/L PBTK NA 95% Rat Human +DTXSID3022748 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022748 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022748 Vd NA 0.3357 L/kg 1compartment NA NA Human Human DTXSID3022748 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022748 TK.Half.Life NA 4.002 hours 1compartment NA NA Human Human -DTXSID3022748 Css NA 0.7489 mg/L 3compartmentss NA 50% Human Human -DTXSID3022748 Css NA 4.44 mg/L 3compartmentss NA 95% Human Human -DTXSID3022748 Css NA 0.5644 mg/L PBTK NA 50% Human Human -DTXSID3022748 Css NA 2.807 mg/L PBTK NA 95% Human Human -DTXSID3022748 Clint NA 0.5075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022748 Fup NA 0.546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022748 Vd NA 0.5953 L/kg 1compartment NA NA Rat Human +DTXSID3022748 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human +DTXSID3022748 Css NA 1.123 mg/L 3compartmentss NA 50% Human Human +DTXSID3022748 Css NA 5.03 mg/L 3compartmentss NA 95% Human Human +DTXSID3022748 Css NA 0.7607 mg/L PBTK NA 50% Human Human +DTXSID3022748 Css NA 3.103 mg/L PBTK NA 95% Human Human +DTXSID3022748 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022748 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022748 Vd NA 0.3442 L/kg 1compartment NA NA Rat Human DTXSID3022748 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022748 TK.Half.Life NA 1.725 hours 1compartment NA NA Rat Human -DTXSID3022748 Css NA 0.2642 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022748 Css NA 1.507 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022748 Css NA 0.1908 mg/L PBTK NA 50% Rat Human -DTXSID3022748 Css NA 0.874 mg/L PBTK NA 95% Rat Human -DTXSID3022796 Clint NA 2.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022796 Fup NA 0.0878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022796 Vd NA 1.822 L/kg 1compartment NA NA Human Human -DTXSID3022796 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3022796 TK.Half.Life NA 31.75 hours 1compartment NA NA Human Human -DTXSID3022796 Css NA 2.522 mg/L 3compartmentss NA 50% Human Human -DTXSID3022796 Css NA 14.08 mg/L 3compartmentss NA 95% Human Human -DTXSID3022796 Css NA 1.719 mg/L PBTK NA 50% Human Human -DTXSID3022796 Css NA 8.843 mg/L PBTK NA 95% Human Human -DTXSID3022796 Clint NA 2.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022796 Fup NA 0.0878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022796 Vd NA 1.428 L/kg 1compartment NA NA Rat Human -DTXSID3022796 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3022796 TK.Half.Life NA 11.02 hours 1compartment NA NA Rat Human -DTXSID3022796 Css NA 1.23 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022796 Css NA 5.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022796 Css NA 0.789 mg/L PBTK NA 50% Rat Human -DTXSID3022796 Css NA 2.974 mg/L PBTK NA 95% Rat Human -DTXSID3022798 Clint NA 2.672 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022798 Fup NA 0.3826 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022798 Vd NA 3.005 L/kg 1compartment NA NA Human Human -DTXSID3022798 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID3022798 TK.Half.Life NA 66.71 hours 1compartment NA NA Human Human -DTXSID3022798 Css NA 2.528 mg/L 3compartmentss NA 50% Human Human -DTXSID3022798 Css NA 11.29 mg/L 3compartmentss NA 95% Human Human -DTXSID3022798 Css NA 1.862 mg/L PBTK NA 50% Human Human -DTXSID3022798 Css NA 7.809 mg/L PBTK NA 95% Human Human -DTXSID3022798 Clint NA 2.672 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022798 Fup NA 0.3826 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022798 Vd NA 2.278 L/kg 1compartment NA NA Rat Human -DTXSID3022798 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID3022798 TK.Half.Life NA 10.03 hours 1compartment NA NA Rat Human -DTXSID3022798 Css NA 1.246 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022798 Css NA 3.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022798 Css NA 0.8782 mg/L PBTK NA 50% Rat Human -DTXSID3022798 Css NA 2.486 mg/L PBTK NA 95% Rat Human -DTXSID3022821 Clint NA 61.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022821 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022821 Vd NA 3.075 L/kg 1compartment NA NA Human Human +DTXSID3022748 TK.Half.Life NA 2.046 hours 1compartment NA NA Rat Human +DTXSID3022748 Css NA 0.006189 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022748 Css NA 0.02732 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022748 Css NA 0.003955 mg/L PBTK NA 50% Rat Human +DTXSID3022748 Css NA 0.01596 mg/L PBTK NA 95% Rat Human +DTXSID3022796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022796 Fup 0.0798 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022796 Vd NA 1.763 L/kg 1compartment NA NA Human Human +DTXSID3022796 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022796 TK.Half.Life NA 6.048 hours 1compartment NA NA Human Human +DTXSID3022796 Css NA 0.3925 mg/L 3compartmentss NA 50% Human Human +DTXSID3022796 Css NA 2.976 mg/L 3compartmentss NA 95% Human Human +DTXSID3022796 Css NA 0.2634 mg/L PBTK NA 50% Human Human +DTXSID3022796 Css NA 1.872 mg/L PBTK NA 95% Human Human +DTXSID3022796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022796 Fup 0.0798 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022796 Vd NA 1.379 L/kg 1compartment NA NA Rat Human +DTXSID3022796 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022796 TK.Half.Life NA 2.327 hours 1compartment NA NA Rat Human +DTXSID3022796 Css NA 0.05101 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022796 Css NA 0.2947 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022796 Css NA 0.03362 mg/L PBTK NA 50% Rat Human +DTXSID3022796 Css NA 0.1841 mg/L PBTK NA 95% Rat Human +DTXSID3022798 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022798 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022798 Vd NA 2.971 L/kg 1compartment NA NA Human Human +DTXSID3022798 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022798 TK.Half.Life NA 11.28 hours 1compartment NA NA Human Human +DTXSID3022798 Css NA 0.354 mg/L 3compartmentss NA 50% Human Human +DTXSID3022798 Css NA 2.157 mg/L 3compartmentss NA 95% Human Human +DTXSID3022798 Css NA 0.257 mg/L PBTK NA 50% Human Human +DTXSID3022798 Css NA 1.502 mg/L PBTK NA 95% Human Human +DTXSID3022798 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022798 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022798 Vd NA 2.251 L/kg 1compartment NA NA Rat Human +DTXSID3022798 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022798 TK.Half.Life NA 2.242 hours 1compartment NA NA Rat Human +DTXSID3022798 Css NA 0.04464 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022798 Css NA 0.2193 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022798 Css NA 0.03231 mg/L PBTK NA 50% Rat Human +DTXSID3022798 Css NA 0.1541 mg/L PBTK NA 95% Rat Human +DTXSID3022821 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022821 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022821 Vd NA 3.264 L/kg 1compartment NA NA Human Human DTXSID3022821 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022821 TK.Half.Life NA 5.996 hours 1compartment NA NA Human Human -DTXSID3022821 Css NA 0.1521 mg/L 3compartmentss NA 50% Human Human -DTXSID3022821 Css NA 1.022 mg/L 3compartmentss NA 95% Human Human -DTXSID3022821 Css NA 0.1065 mg/L PBTK NA 50% Human Human -DTXSID3022821 Css NA 0.6756 mg/L PBTK NA 95% Human Human -DTXSID3022821 Clint NA 61.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022821 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022821 Vd NA 2.354 L/kg 1compartment NA NA Rat Human +DTXSID3022821 TK.Half.Life NA 12.28 hours 1compartment NA NA Human Human +DTXSID3022821 Css NA 0.3462 mg/L 3compartmentss NA 50% Human Human +DTXSID3022821 Css NA 2.318 mg/L 3compartmentss NA 95% Human Human +DTXSID3022821 Css NA 0.2498 mg/L PBTK NA 50% Human Human +DTXSID3022821 Css NA 1.608 mg/L PBTK NA 95% Human Human +DTXSID3022821 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022821 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022821 Vd NA 2.504 L/kg 1compartment NA NA Rat Human DTXSID3022821 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022821 TK.Half.Life NA 1.429 hours 1compartment NA NA Rat Human -DTXSID3022821 Css NA 0.08476 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022821 Css NA 0.494 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022821 Css NA 0.05695 mg/L PBTK NA 50% Rat Human -DTXSID3022821 Css NA 0.32 mg/L PBTK NA 95% Rat Human -DTXSID3022825 Clint NA 25.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3022821 TK.Half.Life NA 2.189 hours 1compartment NA NA Rat Human +DTXSID3022821 Css NA 0.04482 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022821 Css NA 0.266 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022821 Css NA 0.03212 mg/L PBTK NA 50% Rat Human +DTXSID3022821 Css NA 0.1882 mg/L PBTK NA 95% Rat Human +DTXSID3022825 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3022825 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3022825 Vd NA 2.007 L/kg 1compartment NA NA Human Human -DTXSID3022825 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022825 TK.Half.Life NA 10.8 hours 1compartment NA NA Human Human -DTXSID3022825 Css NA 0.7423 mg/L 3compartmentss NA 50% Human Human -DTXSID3022825 Css NA 6.68 mg/L 3compartmentss NA 95% Human Human -DTXSID3022825 Css NA 0.4946 mg/L PBTK NA 50% Human Human -DTXSID3022825 Css NA 4.219 mg/L PBTK NA 95% Human Human -DTXSID3022825 Clint NA 25.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3022825 Vd NA 0.8947 L/kg 1compartment NA NA Human Human +DTXSID3022825 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3022825 TK.Half.Life NA 19.9 hours 1compartment NA NA Human Human +DTXSID3022825 Css NA 3.714 mg/L 3compartmentss NA 50% Human Human +DTXSID3022825 Css NA 33.76 mg/L 3compartmentss NA 95% Human Human +DTXSID3022825 Css NA 2.348 mg/L PBTK NA 50% Human Human +DTXSID3022825 Css NA 20.39 mg/L PBTK NA 95% Human Human +DTXSID3022825 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3022825 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3022825 Vd NA 2.487 L/kg 1compartment NA NA Rat Human +DTXSID3022825 Vd NA 1.934 L/kg 1compartment NA NA Rat Human DTXSID3022825 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022825 TK.Half.Life NA 2.745 hours 1compartment NA NA Rat Human -DTXSID3022825 Css NA 0.1719 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022825 Css NA 0.9599 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022825 Css NA 0.1245 mg/L PBTK NA 50% Rat Human -DTXSID3022825 Css NA 0.6692 mg/L PBTK NA 95% Rat Human -DTXSID3022829 Clint NA 35.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3022825 TK.Half.Life NA 7.262 hours 1compartment NA NA Rat Human +DTXSID3022825 Css NA 0.09786 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022825 Css NA 0.5478 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022825 Css NA 0.07358 mg/L PBTK NA 50% Rat Human +DTXSID3022825 Css NA 0.356 mg/L PBTK NA 95% Rat Human +DTXSID3022829 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID3022829 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3022829 Vd NA 2.685 L/kg 1compartment NA NA Human Human -DTXSID3022829 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022829 TK.Half.Life NA 5.328 hours 1compartment NA NA Human Human -DTXSID3022829 Css NA 0.1665 mg/L 3compartmentss NA 50% Human Human -DTXSID3022829 Css NA 1.045 mg/L 3compartmentss NA 95% Human Human -DTXSID3022829 Css NA 0.1005 mg/L PBTK NA 50% Human Human -DTXSID3022829 Css NA 0.6263 mg/L PBTK NA 95% Human Human -DTXSID3022829 Clint NA 35.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3022829 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3022829 TK.Half.Life NA 46.09 hours 1compartment NA NA Human Human +DTXSID3022829 Css NA 2.148 mg/L 3compartmentss NA 50% Human Human +DTXSID3022829 Css NA 8.426 mg/L 3compartmentss NA 95% Human Human +DTXSID3022829 Css NA 1.372 mg/L PBTK NA 50% Human Human +DTXSID3022829 Css NA 5.388 mg/L PBTK NA 95% Human Human +DTXSID3022829 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID3022829 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3022829 Vd NA 2.086 L/kg 1compartment NA NA Rat Human -DTXSID3022829 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022829 TK.Half.Life NA 1.53 hours 1compartment NA NA Rat Human -DTXSID3022829 Css NA 0.09379 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022829 Css NA 0.461 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022829 Css NA 0.053 mg/L PBTK NA 50% Rat Human -DTXSID3022829 Css NA 0.2595 mg/L PBTK NA 95% Rat Human -DTXSID3022871 Clint NA 1.398 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022871 Fup NA 0.1317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022871 Vd NA 0.701 L/kg 1compartment NA NA Human Human -DTXSID3022871 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3022871 TK.Half.Life NA 10.87 hours 1compartment NA NA Human Human -DTXSID3022871 Css NA 2.248 mg/L 3compartmentss NA 50% Human Human -DTXSID3022871 Css NA 11.96 mg/L 3compartmentss NA 95% Human Human -DTXSID3022871 Css NA 1.457 mg/L PBTK NA 50% Human Human -DTXSID3022871 Css NA 7.215 mg/L PBTK NA 95% Human Human -DTXSID3022871 Clint NA 1.398 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022871 Fup NA 0.1317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022871 Vd NA 0.581 L/kg 1compartment NA NA Rat Human +DTXSID3022829 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3022829 TK.Half.Life NA 10.09 hours 1compartment NA NA Rat Human +DTXSID3022829 Css NA 0.2151 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022829 Css NA 0.5726 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022829 Css NA 0.1424 mg/L PBTK NA 50% Rat Human +DTXSID3022829 Css NA 0.3795 mg/L PBTK NA 95% Rat Human +DTXSID3022871 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022871 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022871 Vd NA 0.8929 L/kg 1compartment NA NA Human Human +DTXSID3022871 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022871 TK.Half.Life NA 3.149 hours 1compartment NA NA Human Human +DTXSID3022871 Css NA 0.1821 mg/L 3compartmentss NA 50% Human Human +DTXSID3022871 Css NA 1.196 mg/L 3compartmentss NA 95% Human Human +DTXSID3022871 Css NA 0.1268 mg/L PBTK NA 50% Human Human +DTXSID3022871 Css NA 0.7734 mg/L PBTK NA 95% Human Human +DTXSID3022871 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022871 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022871 Vd NA 0.7413 L/kg 1compartment NA NA Rat Human DTXSID3022871 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022871 TK.Half.Life NA 4.575 hours 1compartment NA NA Rat Human -DTXSID3022871 Css NA 0.9833 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022871 Css NA 4.277 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022871 Css NA 0.6002 mg/L PBTK NA 50% Rat Human -DTXSID3022871 Css NA 2.393 mg/L PBTK NA 95% Rat Human -DTXSID3022873 Clint NA 1.998 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022873 Fup NA 0.083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022873 Vd NA 1.821 L/kg 1compartment NA NA Human Human -DTXSID3022873 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3022873 TK.Half.Life NA 41.61 hours 1compartment NA NA Human Human -DTXSID3022873 Css NA 3.284 mg/L 3compartmentss NA 50% Human Human -DTXSID3022873 Css NA 17.4 mg/L 3compartmentss NA 95% Human Human -DTXSID3022873 Css NA 2.243 mg/L PBTK NA 50% Human Human -DTXSID3022873 Css NA 10.83 mg/L PBTK NA 95% Human Human -DTXSID3022873 Clint NA 1.998 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022873 Fup NA 0.083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022873 Vd NA 1.459 L/kg 1compartment NA NA Rat Human -DTXSID3022873 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3022873 TK.Half.Life NA 14.66 hours 1compartment NA NA Rat Human -DTXSID3022873 Css NA 1.54 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022873 Css NA 6.204 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022873 Css NA 0.9983 mg/L PBTK NA 50% Rat Human -DTXSID3022873 Css NA 3.598 mg/L PBTK NA 95% Rat Human +DTXSID3022871 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human +DTXSID3022871 Css NA 0.00178 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022871 Css NA 0.01002 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022871 Css NA 0.00118 mg/L PBTK NA 50% Rat Human +DTXSID3022871 Css NA 0.006127 mg/L PBTK NA 95% Rat Human +DTXSID3022873 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022873 Fup 0.0772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022873 Vd NA 1.776 L/kg 1compartment NA NA Human Human +DTXSID3022873 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022873 TK.Half.Life NA 6.086 hours 1compartment NA NA Human Human +DTXSID3022873 Css NA 0.3944 mg/L 3compartmentss NA 50% Human Human +DTXSID3022873 Css NA 2.869 mg/L 3compartmentss NA 95% Human Human +DTXSID3022873 Css NA 0.2679 mg/L PBTK NA 50% Human Human +DTXSID3022873 Css NA 1.838 mg/L PBTK NA 95% Human Human +DTXSID3022873 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022873 Fup 0.0772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022873 Vd NA 1.421 L/kg 1compartment NA NA Rat Human +DTXSID3022873 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022873 TK.Half.Life NA 2.452 hours 1compartment NA NA Rat Human +DTXSID3022873 Css NA 0.05093 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022873 Css NA 0.2976 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022873 Css NA 0.03395 mg/L PBTK NA 50% Rat Human +DTXSID3022873 Css NA 0.1858 mg/L PBTK NA 95% Rat Human DTXSID3022875 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3022875 Fup NA 0.6523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022875 Vd NA 1.59 L/kg 1compartment NA NA Human Human -DTXSID3022875 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3022875 TK.Half.Life NA 15.77 hours 1compartment NA NA Human Human -DTXSID3022875 Css NA 0.9765 mg/L 3compartmentss NA 50% Human Human -DTXSID3022875 Css NA 6.966 mg/L 3compartmentss NA 95% Human Human -DTXSID3022875 Css NA 0.9198 mg/L PBTK NA 50% Human Human -DTXSID3022875 Css NA 4.672 mg/L PBTK NA 95% Human Human +DTXSID3022875 Vd NA 2.647 L/kg 1compartment NA NA Human Human +DTXSID3022875 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3022875 TK.Half.Life NA 26.31 hours 1compartment NA NA Human Human +DTXSID3022875 Css NA 0.7072 mg/L 3compartmentss NA 50% Human Human +DTXSID3022875 Css NA 5.76 mg/L 3compartmentss NA 95% Human Human +DTXSID3022875 Css NA 0.7942 mg/L PBTK NA 50% Human Human +DTXSID3022875 Css NA 4.05 mg/L PBTK NA 95% Human Human DTXSID3022875 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3022875 Fup NA 0.6523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022875 Vd NA 1.616 L/kg 1compartment NA NA Rat Human +DTXSID3022875 Vd NA 2.688 L/kg 1compartment NA NA Rat Human DTXSID3022875 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022875 TK.Half.Life NA 5.462 hours 1compartment NA NA Rat Human -DTXSID3022875 Css NA 0.2534 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022875 Css NA 1.789 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022875 Css NA 0.233 mg/L PBTK NA 50% Rat Human -DTXSID3022875 Css NA 1.109 mg/L PBTK NA 95% Rat Human -DTXSID3022877 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3022875 TK.Half.Life NA 9.089 hours 1compartment NA NA Rat Human +DTXSID3022875 Css NA 0.01328 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022875 Css NA 0.1228 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022875 Css NA 0.01436 mg/L PBTK NA 50% Rat Human +DTXSID3022875 Css NA 0.09104 mg/L PBTK NA 95% Rat Human +DTXSID3022877 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3022877 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3022877 Vd NA 0.8662 L/kg 1compartment NA NA Human Human DTXSID3022877 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022877 TK.Half.Life NA 6.442 hours 1compartment NA NA Human Human -DTXSID3022877 Css NA 0.9188 mg/L 3compartmentss NA 50% Human Human -DTXSID3022877 Css NA 5.411 mg/L 3compartmentss NA 95% Human Human -DTXSID3022877 Css NA 0.7754 mg/L PBTK NA 50% Human Human -DTXSID3022877 Css NA 3.617 mg/L PBTK NA 95% Human Human -DTXSID3022877 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3022877 TK.Half.Life NA 0.6394 hours 1compartment NA NA Human Human +DTXSID3022877 Css NA 0.008806 mg/L 3compartmentss NA 50% Human Human +DTXSID3022877 Css NA 0.129 mg/L 3compartmentss NA 95% Human Human +DTXSID3022877 Css NA 0.00725 mg/L PBTK NA 50% Human Human +DTXSID3022877 Css NA 0.09474 mg/L PBTK NA 95% Human Human +DTXSID3022877 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3022877 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3022877 Vd NA 0.913 L/kg 1compartment NA NA Rat Human DTXSID3022877 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022877 TK.Half.Life NA 2.314 hours 1compartment NA NA Rat Human -DTXSID3022877 Css NA 0.237 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022877 Css NA 1.353 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022877 Css NA 0.1935 mg/L PBTK NA 50% Rat Human -DTXSID3022877 Css NA 0.8192 mg/L PBTK NA 95% Rat Human -DTXSID3022902 Clint NA 5.495 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022902 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022902 Vd NA 2.388 L/kg 1compartment NA NA Human Human -DTXSID3022902 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID3022902 TK.Half.Life NA 45.04 hours 1compartment NA NA Human Human -DTXSID3022902 Css NA 2.631 mg/L 3compartmentss NA 50% Human Human -DTXSID3022902 Css NA 15.53 mg/L 3compartmentss NA 95% Human Human -DTXSID3022902 Css NA 1.777 mg/L PBTK NA 50% Human Human -DTXSID3022902 Css NA 9.928 mg/L PBTK NA 95% Human Human -DTXSID3022902 Clint NA 5.495 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022902 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022902 Vd NA 1.789 L/kg 1compartment NA NA Rat Human -DTXSID3022902 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3022902 TK.Half.Life NA 11.39 hours 1compartment NA NA Rat Human -DTXSID3022902 Css NA 1.389 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022902 Css NA 5.726 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022902 Css NA 0.8934 mg/L PBTK NA 50% Rat Human -DTXSID3022902 Css NA 3.496 mg/L PBTK NA 95% Rat Human -DTXSID3022904 Clint NA 17.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022904 Fup NA 0.0509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022904 Vd NA 1.393 L/kg 1compartment NA NA Human Human +DTXSID3022877 TK.Half.Life NA 0.323 hours 1compartment NA NA Rat Human +DTXSID3022877 Css NA 6.816e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022877 Css NA 0.001132 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022877 Css NA 5.527e-05 mg/L PBTK NA 50% Rat Human +DTXSID3022877 Css NA 0.0007702 mg/L PBTK NA 95% Rat Human +DTXSID3022902 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022902 Fup 0.0727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022902 Vd NA 2.448 L/kg 1compartment NA NA Human Human +DTXSID3022902 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3022902 TK.Half.Life NA 13.12 hours 1compartment NA NA Human Human +DTXSID3022902 Css NA 0.6409 mg/L 3compartmentss NA 50% Human Human +DTXSID3022902 Css NA 4.152 mg/L 3compartmentss NA 95% Human Human +DTXSID3022902 Css NA 0.4324 mg/L PBTK NA 50% Human Human +DTXSID3022902 Css NA 2.724 mg/L PBTK NA 95% Human Human +DTXSID3022902 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022902 Fup 0.0727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022902 Vd NA 1.835 L/kg 1compartment NA NA Rat Human +DTXSID3022902 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3022902 TK.Half.Life NA 3.455 hours 1compartment NA NA Rat Human +DTXSID3022902 Css NA 0.08183 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022902 Css NA 0.4458 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022902 Css NA 0.05456 mg/L PBTK NA 50% Rat Human +DTXSID3022902 Css NA 0.2879 mg/L PBTK NA 95% Rat Human +DTXSID3022904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022904 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022904 Vd NA 1.898 L/kg 1compartment NA NA Human Human DTXSID3022904 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022904 TK.Half.Life NA 7.633 hours 1compartment NA NA Human Human -DTXSID3022904 Css NA 0.7862 mg/L 3compartmentss NA 50% Human Human -DTXSID3022904 Css NA 6.052 mg/L 3compartmentss NA 95% Human Human -DTXSID3022904 Css NA 0.5006 mg/L PBTK NA 50% Human Human -DTXSID3022904 Css NA 3.727 mg/L PBTK NA 95% Human Human -DTXSID3022904 Clint NA 17.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022904 Fup NA 0.0509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022904 Vd NA 1.044 L/kg 1compartment NA NA Rat Human +DTXSID3022904 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human +DTXSID3022904 Css NA 0.3272 mg/L 3compartmentss NA 50% Human Human +DTXSID3022904 Css NA 2.267 mg/L 3compartmentss NA 95% Human Human +DTXSID3022904 Css NA 0.2208 mg/L PBTK NA 50% Human Human +DTXSID3022904 Css NA 1.455 mg/L PBTK NA 95% Human Human +DTXSID3022904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022904 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022904 Vd NA 1.434 L/kg 1compartment NA NA Rat Human DTXSID3022904 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022904 TK.Half.Life NA 3.008 hours 1compartment NA NA Rat Human -DTXSID3022904 Css NA 0.4404 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022904 Css NA 2.559 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022904 Css NA 0.2628 mg/L PBTK NA 50% Rat Human -DTXSID3022904 Css NA 1.46 mg/L PBTK NA 95% Rat Human -DTXSID3022906 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022906 Fup NA 0.8641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022906 Vd NA 1.562 L/kg 1compartment NA NA Human Human +DTXSID3022904 TK.Half.Life NA 1.967 hours 1compartment NA NA Rat Human +DTXSID3022904 Css NA 0.04163 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022904 Css NA 0.2442 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022904 Css NA 0.02779 mg/L PBTK NA 50% Rat Human +DTXSID3022904 Css NA 0.1537 mg/L PBTK NA 95% Rat Human +DTXSID3022906 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022906 Fup 0.869 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022906 Vd NA 1.624 L/kg 1compartment NA NA Human Human DTXSID3022906 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3022906 TK.Half.Life NA 11.7 hours 1compartment NA NA Human Human -DTXSID3022906 Css NA 0.8173 mg/L 3compartmentss NA 50% Human Human -DTXSID3022906 Css NA 5.267 mg/L 3compartmentss NA 95% Human Human -DTXSID3022906 Css NA 0.7787 mg/L PBTK NA 50% Human Human -DTXSID3022906 Css NA 3.565 mg/L PBTK NA 95% Human Human -DTXSID3022906 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022906 Fup NA 0.8641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022906 Vd NA 1.598 L/kg 1compartment NA NA Rat Human +DTXSID3022906 TK.Half.Life NA 12.09 hours 1compartment NA NA Human Human +DTXSID3022906 Css NA 0.7051 mg/L 3compartmentss NA 50% Human Human +DTXSID3022906 Css NA 4.494 mg/L 3compartmentss NA 95% Human Human +DTXSID3022906 Css NA 0.6745 mg/L PBTK NA 50% Human Human +DTXSID3022906 Css NA 3.053 mg/L PBTK NA 95% Human Human +DTXSID3022906 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022906 Fup 0.869 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022906 Vd NA 1.659 L/kg 1compartment NA NA Rat Human DTXSID3022906 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022906 TK.Half.Life NA 4.077 hours 1compartment NA NA Rat Human -DTXSID3022906 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022906 Css NA 1.331 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022906 Css NA 0.1942 mg/L PBTK NA 50% Rat Human -DTXSID3022906 Css NA 0.8399 mg/L PBTK NA 95% Rat Human +DTXSID3022906 TK.Half.Life NA 4.209 hours 1compartment NA NA Rat Human +DTXSID3022906 Css NA 0.01781 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022906 Css NA 0.1326 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022906 Css NA 0.01672 mg/L PBTK NA 50% Rat Human +DTXSID3022906 Css NA 0.09128 mg/L PBTK NA 95% Rat Human DTXSID3022908 Clint 52.64 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.106.011569 NA Human Human DTXSID3022908 Fup 0.45 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID3022908 Vd NA 7.411 L/kg 1compartment NA NA Human Human +DTXSID3022908 Vd NA 7.693 L/kg 1compartment NA NA Human Human DTXSID3022908 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022908 TK.Half.Life NA 2.594 hours 1compartment NA NA Human Human -DTXSID3022908 Css NA 0.004623 mg/L 3compartmentss NA 50% Human Human -DTXSID3022908 Css NA 0.05067 mg/L 3compartmentss NA 95% Human Human -DTXSID3022908 Css NA 0.009384 mg/L PBTK NA 50% Human Human -DTXSID3022908 Css NA 0.06713 mg/L PBTK NA 95% Human Human +DTXSID3022908 TK.Half.Life NA 2.671 hours 1compartment NA NA Human Human +DTXSID3022908 Css NA 0.003502 mg/L 3compartmentss NA 50% Human Human +DTXSID3022908 Css NA 0.03929 mg/L 3compartmentss NA 95% Human Human +DTXSID3022908 Css NA 0.006988 mg/L PBTK NA 50% Human Human +DTXSID3022908 Css NA 0.057 mg/L PBTK NA 95% Human Human DTXSID3022908 Clint 145 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID3022908 Fup 0.45 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID3022908 Vd NA 7.505 L/kg 1compartment NA NA Rat Rat +DTXSID3022908 Vd NA 7.685 L/kg 1compartment NA NA Rat Rat DTXSID3022908 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID3022908 TK.Half.Life NA 0.9064 hours 1compartment NA NA Rat Rat -DTXSID3022908 Css NA 0.0008634 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3022908 Css NA 0.008271 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3022908 Css NA 0.001801 mg/L PBTK NA 50% Rat Rat -DTXSID3022908 Css NA 0.01154 mg/L PBTK NA 95% Rat Rat -DTXSID3022950 Clint NA 44.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022950 Fup NA 0.0916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022950 Vd NA 2.384 L/kg 1compartment NA NA Human Human +DTXSID3022908 TK.Half.Life NA 0.9069 hours 1compartment NA NA Rat Rat +DTXSID3022908 Css NA 0.0001237 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3022908 Css NA 0.001475 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3022908 Css NA 0.0002699 mg/L PBTK NA 50% Rat Rat +DTXSID3022908 Css NA 0.002209 mg/L PBTK NA 95% Rat Rat +DTXSID3022950 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022950 Fup 0.0832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022950 Vd NA 3.018 L/kg 1compartment NA NA Human Human DTXSID3022950 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022950 TK.Half.Life NA 2.804 hours 1compartment NA NA Human Human -DTXSID3022950 Css NA 0.07278 mg/L 3compartmentss NA 50% Human Human -DTXSID3022950 Css NA 0.6993 mg/L 3compartmentss NA 95% Human Human -DTXSID3022950 Css NA 0.06161 mg/L PBTK NA 50% Human Human -DTXSID3022950 Css NA 0.5175 mg/L PBTK NA 95% Human Human -DTXSID3022950 Clint NA 44.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022950 Fup NA 0.0916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022950 Vd NA 2.364 L/kg 1compartment NA NA Rat Human +DTXSID3022950 TK.Half.Life NA 4.297 hours 1compartment NA NA Human Human +DTXSID3022950 Css NA 0.09767 mg/L 3compartmentss NA 50% Human Human +DTXSID3022950 Css NA 0.9833 mg/L 3compartmentss NA 95% Human Human +DTXSID3022950 Css NA 0.08938 mg/L PBTK NA 50% Human Human +DTXSID3022950 Css NA 0.7244 mg/L PBTK NA 95% Human Human +DTXSID3022950 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022950 Fup 0.0832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022950 Vd NA 2.935 L/kg 1compartment NA NA Rat Human DTXSID3022950 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022950 TK.Half.Life NA 1.53 hours 1compartment NA NA Rat Human -DTXSID3022950 Css NA 0.04019 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022950 Css NA 0.3155 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022950 Css NA 0.03294 mg/L PBTK NA 50% Rat Human -DTXSID3022950 Css NA 0.2206 mg/L PBTK NA 95% Rat Human -DTXSID3022956 Clint NA 1.442 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022956 Fup NA 0.6502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022956 Vd NA 0.9587 L/kg 1compartment NA NA Human Human +DTXSID3022950 TK.Half.Life NA 2.298 hours 1compartment NA NA Rat Human +DTXSID3022950 Css NA 0.0125 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022950 Css NA 0.09371 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022950 Css NA 0.01163 mg/L PBTK NA 50% Rat Human +DTXSID3022950 Css NA 0.06906 mg/L PBTK NA 95% Rat Human +DTXSID3022956 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022956 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022956 Vd NA 0.5677 L/kg 1compartment NA NA Human Human DTXSID3022956 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022956 TK.Half.Life NA 3.216 hours 1compartment NA NA Human Human -DTXSID3022956 Css NA 0.346 mg/L 3compartmentss NA 50% Human Human -DTXSID3022956 Css NA 2.559 mg/L 3compartmentss NA 95% Human Human -DTXSID3022956 Css NA 0.285 mg/L PBTK NA 50% Human Human -DTXSID3022956 Css NA 1.675 mg/L PBTK NA 95% Human Human -DTXSID3022956 Clint NA 1.442 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022956 Fup NA 0.6502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022956 Vd NA 0.8845 L/kg 1compartment NA NA Rat Human +DTXSID3022956 TK.Half.Life NA 9.047 hours 1compartment NA NA Human Human +DTXSID3022956 Css NA 1.685 mg/L 3compartmentss NA 50% Human Human +DTXSID3022956 Css NA 7.449 mg/L 3compartmentss NA 95% Human Human +DTXSID3022956 Css NA 1.288 mg/L PBTK NA 50% Human Human +DTXSID3022956 Css NA 4.743 mg/L PBTK NA 95% Human Human +DTXSID3022956 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022956 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022956 Vd NA 0.5722 L/kg 1compartment NA NA Rat Human DTXSID3022956 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022956 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human -DTXSID3022956 Css NA 0.1394 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022956 Css NA 0.9483 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022956 Css NA 0.1124 mg/L PBTK NA 50% Rat Human -DTXSID3022956 Css NA 0.5655 mg/L PBTK NA 95% Rat Human -DTXSID3022958 Clint NA 6.814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022958 Fup NA 0.2259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3022958 Vd NA 3.359 L/kg 1compartment NA NA Human Human +DTXSID3022956 TK.Half.Life NA 3.108 hours 1compartment NA NA Rat Human +DTXSID3022956 Css NA 0.107 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022956 Css NA 0.4209 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022956 Css NA 0.08083 mg/L PBTK NA 50% Rat Human +DTXSID3022956 Css NA 0.261 mg/L PBTK NA 95% Rat Human +DTXSID3022958 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022958 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3022958 Vd NA 3.343 L/kg 1compartment NA NA Human Human DTXSID3022958 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3022958 TK.Half.Life NA 8.439 hours 1compartment NA NA Human Human -DTXSID3022958 Css NA 0.1686 mg/L 3compartmentss NA 50% Human Human -DTXSID3022958 Css NA 1.194 mg/L 3compartmentss NA 95% Human Human -DTXSID3022958 Css NA 0.1826 mg/L PBTK NA 50% Human Human -DTXSID3022958 Css NA 1.023 mg/L PBTK NA 95% Human Human -DTXSID3022958 Clint NA 6.814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022958 Fup NA 0.2259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3022958 Vd NA 3.336 L/kg 1compartment NA NA Rat Human +DTXSID3022958 TK.Half.Life NA 12.25 hours 1compartment NA NA Human Human +DTXSID3022958 Css NA 0.3145 mg/L 3compartmentss NA 50% Human Human +DTXSID3022958 Css NA 2.492 mg/L 3compartmentss NA 95% Human Human +DTXSID3022958 Css NA 0.3022 mg/L PBTK NA 50% Human Human +DTXSID3022958 Css NA 1.98 mg/L PBTK NA 95% Human Human +DTXSID3022958 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022958 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3022958 Vd NA 3.196 L/kg 1compartment NA NA Rat Human DTXSID3022958 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3022958 TK.Half.Life NA 4.748 hours 1compartment NA NA Rat Human -DTXSID3022958 Css NA 0.08536 mg/L 3compartmentss NA 50% Rat Human -DTXSID3022958 Css NA 0.4518 mg/L 3compartmentss NA 95% Rat Human -DTXSID3022958 Css NA 0.09191 mg/L PBTK NA 50% Rat Human -DTXSID3022958 Css NA 0.3714 mg/L PBTK NA 95% Rat Human -DTXSID3023001 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023001 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023001 Vd NA 17.45 L/kg 1compartment NA NA Human Human -DTXSID3023001 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID3023001 TK.Half.Life NA 839200 hours 1compartment NA NA Human Human -DTXSID3023001 Css NA 2005 mg/L 3compartmentss NA 50% Human Human -DTXSID3023001 Css NA 4845 mg/L 3compartmentss NA 95% Human Human -DTXSID3023001 Css NA 3727 mg/L PBTK NA 50% Human Human -DTXSID3023001 Css NA 7940 mg/L PBTK NA 95% Human Human -DTXSID3023001 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023001 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023001 Vd NA 14.09 L/kg 1compartment NA NA Rat Human -DTXSID3023001 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID3023001 TK.Half.Life NA 58050 hours 1compartment NA NA Rat Human -DTXSID3023001 Css NA 514.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023001 Css NA 828.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023001 Css NA 999.8 mg/L PBTK NA 50% Rat Human -DTXSID3023001 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID3023005 Clint NA 2.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023005 Fup NA 0.048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023005 Vd NA 0.4305 L/kg 1compartment NA NA Human Human -DTXSID3023005 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3023005 TK.Half.Life NA 11.1 hours 1compartment NA NA Human Human -DTXSID3023005 Css NA 4.464 mg/L 3compartmentss NA 50% Human Human -DTXSID3023005 Css NA 27.73 mg/L 3compartmentss NA 95% Human Human -DTXSID3023005 Css NA 2.71 mg/L PBTK NA 50% Human Human -DTXSID3023005 Css NA 16.39 mg/L PBTK NA 95% Human Human -DTXSID3023005 Clint NA 2.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023005 Fup NA 0.048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023005 Vd NA 0.3553 L/kg 1compartment NA NA Rat Human +DTXSID3022958 TK.Half.Life NA 6.167 hours 1compartment NA NA Rat Human +DTXSID3022958 Css NA 0.03772 mg/L 3compartmentss NA 50% Rat Human +DTXSID3022958 Css NA 0.24 mg/L 3compartmentss NA 95% Rat Human +DTXSID3022958 Css NA 0.03696 mg/L PBTK NA 50% Rat Human +DTXSID3022958 Css NA 0.1801 mg/L PBTK NA 95% Rat Human +DTXSID3023001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023001 Fup 0.0214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023001 Vd NA 33.24 L/kg 1compartment NA NA Human Human +DTXSID3023001 Days.Css NA 238 Days PBTK NA NA Human Human +DTXSID3023001 TK.Half.Life NA 980 hours 1compartment NA NA Human Human +DTXSID3023001 Css NA 0.67 mg/L 3compartmentss NA 50% Human Human +DTXSID3023001 Css NA 4.115 mg/L 3compartmentss NA 95% Human Human +DTXSID3023001 Css NA 2.362 mg/L PBTK NA 50% Human Human +DTXSID3023001 Css NA 13.52 mg/L PBTK NA 95% Human Human +DTXSID3023001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023001 Fup 0.0214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023001 Vd NA 27.57 L/kg 1compartment NA NA Rat Human +DTXSID3023001 Days.Css NA 146 Days PBTK NA NA Rat Human +DTXSID3023001 TK.Half.Life NA 139.7 hours 1compartment NA NA Rat Human +DTXSID3023001 Css NA 0.07989 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023001 Css NA 0.3679 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023001 Css NA 0.3048 mg/L PBTK NA 50% Rat Human +DTXSID3023001 Css NA 1.407 mg/L PBTK NA 95% Rat Human +DTXSID3023005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023005 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023005 Vd NA 0.398 L/kg 1compartment NA NA Human Human +DTXSID3023005 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023005 TK.Half.Life NA 0.6172 hours 1compartment NA NA Human Human +DTXSID3023005 Css NA 0.0959 mg/L 3compartmentss NA 50% Human Human +DTXSID3023005 Css NA 0.666 mg/L 3compartmentss NA 95% Human Human +DTXSID3023005 Css NA 0.06324 mg/L PBTK NA 50% Human Human +DTXSID3023005 Css NA 0.4195 mg/L PBTK NA 95% Human Human +DTXSID3023005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023005 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023005 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human DTXSID3023005 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023005 TK.Half.Life NA 5.239 hours 1compartment NA NA Rat Human -DTXSID3023005 Css NA 2.183 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023005 Css NA 10.23 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023005 Css NA 1.232 mg/L PBTK NA 50% Rat Human -DTXSID3023005 Css NA 5.577 mg/L PBTK NA 95% Rat Human -DTXSID3023007 Clint NA 27.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023007 Fup NA 0.3114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023007 Vd NA 1.269 L/kg 1compartment NA NA Human Human +DTXSID3023005 TK.Half.Life NA 0.325 hours 1compartment NA NA Rat Human +DTXSID3023005 Css NA 0.01199 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023005 Css NA 0.06694 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023005 Css NA 0.007774 mg/L PBTK NA 50% Rat Human +DTXSID3023005 Css NA 0.04053 mg/L PBTK NA 95% Rat Human +DTXSID3023007 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023007 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023007 Vd NA 1.697 L/kg 1compartment NA NA Human Human DTXSID3023007 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023007 TK.Half.Life NA 1.489 hours 1compartment NA NA Human Human -DTXSID3023007 Css NA 0.05609 mg/L 3compartmentss NA 50% Human Human -DTXSID3023007 Css NA 0.3983 mg/L 3compartmentss NA 95% Human Human -DTXSID3023007 Css NA 0.04275 mg/L PBTK NA 50% Human Human -DTXSID3023007 Css NA 0.2783 mg/L PBTK NA 95% Human Human -DTXSID3023007 Clint NA 27.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023007 Fup NA 0.3114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023007 Vd NA 1.064 L/kg 1compartment NA NA Rat Human +DTXSID3023007 TK.Half.Life NA 5.559 hours 1compartment NA NA Human Human +DTXSID3023007 Css NA 0.3015 mg/L 3compartmentss NA 50% Human Human +DTXSID3023007 Css NA 1.729 mg/L 3compartmentss NA 95% Human Human +DTXSID3023007 Css NA 0.2262 mg/L PBTK NA 50% Human Human +DTXSID3023007 Css NA 1.206 mg/L PBTK NA 95% Human Human +DTXSID3023007 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023007 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023007 Vd NA 1.359 L/kg 1compartment NA NA Rat Human DTXSID3023007 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023007 TK.Half.Life NA 0.6205 hours 1compartment NA NA Rat Human -DTXSID3023007 Css NA 0.03018 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023007 Css NA 0.1747 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023007 Css NA 0.022 mg/L PBTK NA 50% Rat Human -DTXSID3023007 Css NA 0.1179 mg/L PBTK NA 95% Rat Human -DTXSID3023051 Clint NA 0.9904 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023051 Fup NA 0.0174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023051 Vd NA 0.2426 L/kg 1compartment NA NA Human Human -DTXSID3023051 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3023051 TK.Half.Life NA 34.01 hours 1compartment NA NA Human Human -DTXSID3023051 Css NA 23.99 mg/L 3compartmentss NA 50% Human Human -DTXSID3023051 Css NA 168.2 mg/L 3compartmentss NA 95% Human Human -DTXSID3023051 Css NA 14.46 mg/L PBTK NA 50% Human Human -DTXSID3023051 Css NA 95.92 mg/L PBTK NA 95% Human Human -DTXSID3023051 Clint NA 0.9904 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023051 Fup NA 0.0174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023051 Vd NA 0.2318 L/kg 1compartment NA NA Rat Human -DTXSID3023051 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3023051 TK.Half.Life NA 16.27 hours 1compartment NA NA Rat Human -DTXSID3023051 Css NA 10.16 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023051 Css NA 60.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023051 Css NA 5.656 mg/L PBTK NA 50% Rat Human -DTXSID3023051 Css NA 32.75 mg/L PBTK NA 95% Rat Human -DTXSID3023057 Clint NA 0.04073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023057 Fup NA 0.7491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023057 Vd NA 0.5243 L/kg 1compartment NA NA Human Human +DTXSID3023007 TK.Half.Life NA 2.138 hours 1compartment NA NA Rat Human +DTXSID3023007 Css NA 0.03572 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023007 Css NA 0.1496 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023007 Css NA 0.02694 mg/L PBTK NA 50% Rat Human +DTXSID3023007 Css NA 0.1003 mg/L PBTK NA 95% Rat Human +DTXSID30230090 Clint 20.05 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30230090 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30230090 Vd NA 0.4704 L/kg 1compartment NA NA Human Human +DTXSID30230090 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30230090 TK.Half.Life NA 1.172 hours 1compartment NA NA Human Human +DTXSID30230090 Css NA 0.23 mg/L 3compartmentss NA 50% Human Human +DTXSID30230090 Css NA 1.976 mg/L 3compartmentss NA 95% Human Human +DTXSID30230090 Css NA 0.145 mg/L PBTK NA 50% Human Human +DTXSID30230090 Css NA 1.189 mg/L PBTK NA 95% Human Human +DTXSID30230090 Clint 20.05 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30230090 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30230090 Vd NA 0.4203 L/kg 1compartment NA NA Rat Human +DTXSID30230090 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30230090 TK.Half.Life NA 0.6134 hours 1compartment NA NA Rat Human +DTXSID30230090 Css NA 0.01126 mg/L 3compartmentss NA 50% Rat Human +DTXSID30230090 Css NA 0.1042 mg/L 3compartmentss NA 95% Rat Human +DTXSID30230090 Css NA 0.006856 mg/L PBTK NA 50% Rat Human +DTXSID30230090 Css NA 0.0607 mg/L PBTK NA 95% Rat Human +DTXSID3023051 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023051 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023051 Vd NA 1.758 L/kg 1compartment NA NA Human Human +DTXSID3023051 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3023051 TK.Half.Life NA 17.6 hours 1compartment NA NA Human Human +DTXSID3023051 Css NA 1.51 mg/L 3compartmentss NA 50% Human Human +DTXSID3023051 Css NA 13.28 mg/L 3compartmentss NA 95% Human Human +DTXSID3023051 Css NA 0.9563 mg/L PBTK NA 50% Human Human +DTXSID3023051 Css NA 8.144 mg/L PBTK NA 95% Human Human +DTXSID3023051 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023051 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023051 Vd NA 1.304 L/kg 1compartment NA NA Rat Human +DTXSID3023051 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023051 TK.Half.Life NA 6.217 hours 1compartment NA NA Rat Human +DTXSID3023051 Css NA 0.1956 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023051 Css NA 1.399 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023051 Css NA 0.1211 mg/L PBTK NA 50% Rat Human +DTXSID3023051 Css NA 0.8197 mg/L PBTK NA 95% Rat Human +DTXSID3023057 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023057 Fup 0.792 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023057 Vd NA 0.5408 L/kg 1compartment NA NA Human Human DTXSID3023057 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023057 TK.Half.Life NA 4.242 hours 1compartment NA NA Human Human -DTXSID3023057 Css NA 1.036 mg/L 3compartmentss NA 50% Human Human -DTXSID3023057 Css NA 5.873 mg/L 3compartmentss NA 95% Human Human -DTXSID3023057 Css NA 0.7806 mg/L PBTK NA 50% Human Human -DTXSID3023057 Css NA 3.656 mg/L PBTK NA 95% Human Human -DTXSID3023057 Clint NA 0.04073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023057 Fup NA 0.7491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023057 Vd NA 0.5505 L/kg 1compartment NA NA Rat Human +DTXSID3023057 TK.Half.Life NA 4.418 hours 1compartment NA NA Human Human +DTXSID3023057 Css NA 0.5894 mg/L 3compartmentss NA 50% Human Human +DTXSID3023057 Css NA 3.482 mg/L 3compartmentss NA 95% Human Human +DTXSID3023057 Css NA 0.4506 mg/L PBTK NA 50% Human Human +DTXSID3023057 Css NA 2.174 mg/L PBTK NA 95% Human Human +DTXSID3023057 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023057 Fup 0.792 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023057 Vd NA 0.568 L/kg 1compartment NA NA Rat Human DTXSID3023057 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023057 TK.Half.Life NA 1.569 hours 1compartment NA NA Rat Human -DTXSID3023057 Css NA 0.2792 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023057 Css NA 1.728 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023057 Css NA 0.2028 mg/L PBTK NA 50% Rat Human -DTXSID3023057 Css NA 0.9988 mg/L PBTK NA 95% Rat Human +DTXSID3023057 TK.Half.Life NA 1.581 hours 1compartment NA NA Rat Human +DTXSID3023057 Css NA 0.003025 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023057 Css NA 0.01854 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023057 Css NA 0.002218 mg/L PBTK NA 50% Rat Human +DTXSID3023057 Css NA 0.01137 mg/L PBTK NA 95% Rat Human DTXSID3023059 Clint NA 0.03591 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3023059 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3023059 Vd NA 0.7906 L/kg 1compartment NA NA Human Human +DTXSID3023059 Vd NA 0.7693 L/kg 1compartment NA NA Human Human DTXSID3023059 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023059 TK.Half.Life NA 4.834 hours 1compartment NA NA Human Human -DTXSID3023059 Css NA 0.7646 mg/L 3compartmentss NA 50% Human Human -DTXSID3023059 Css NA 5.048 mg/L 3compartmentss NA 95% Human Human -DTXSID3023059 Css NA 0.6478 mg/L PBTK NA 50% Human Human -DTXSID3023059 Css NA 3.293 mg/L PBTK NA 95% Human Human +DTXSID3023059 TK.Half.Life NA 4.699 hours 1compartment NA NA Human Human +DTXSID3023059 Css NA 0.747 mg/L 3compartmentss NA 50% Human Human +DTXSID3023059 Css NA 4.862 mg/L 3compartmentss NA 95% Human Human +DTXSID3023059 Css NA 0.6297 mg/L PBTK NA 50% Human Human +DTXSID3023059 Css NA 3.18 mg/L PBTK NA 95% Human Human DTXSID3023059 Clint NA 0.03591 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3023059 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3023059 Vd NA 0.8268 L/kg 1compartment NA NA Rat Human +DTXSID3023059 Vd NA 0.8087 L/kg 1compartment NA NA Rat Human DTXSID3023059 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023059 TK.Half.Life NA 1.772 hours 1compartment NA NA Rat Human -DTXSID3023059 Css NA 0.2018 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023059 Css NA 1.261 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023059 Css NA 0.1673 mg/L PBTK NA 50% Rat Human -DTXSID3023059 Css NA 0.7615 mg/L PBTK NA 95% Rat Human -DTXSID3023132 Clint NA 4.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023132 Fup NA 0.1744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023132 Vd NA 0.2809 L/kg 1compartment NA NA Human Human +DTXSID3023059 TK.Half.Life NA 1.733 hours 1compartment NA NA Rat Human +DTXSID3023059 Css NA 0.04541 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023059 Css NA 0.2924 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023059 Css NA 0.03886 mg/L PBTK NA 50% Rat Human +DTXSID3023059 Css NA 0.1822 mg/L PBTK NA 95% Rat Human +DTXSID3023132 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023132 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023132 Vd NA 0.3073 L/kg 1compartment NA NA Human Human DTXSID3023132 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023132 TK.Half.Life NA 1.339 hours 1compartment NA NA Human Human -DTXSID3023132 Css NA 0.5536 mg/L 3compartmentss NA 50% Human Human -DTXSID3023132 Css NA 3.021 mg/L 3compartmentss NA 95% Human Human -DTXSID3023132 Css NA 0.3479 mg/L PBTK NA 50% Human Human -DTXSID3023132 Css NA 1.824 mg/L PBTK NA 95% Human Human -DTXSID3023132 Clint NA 4.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023132 Fup NA 0.1744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023132 Vd NA 0.2818 L/kg 1compartment NA NA Rat Human +DTXSID3023132 TK.Half.Life NA 9.041 hours 1compartment NA NA Human Human +DTXSID3023132 Css NA 2.012 mg/L 3compartmentss NA 50% Human Human +DTXSID3023132 Css NA 7.814 mg/L 3compartmentss NA 95% Human Human +DTXSID3023132 Css NA 1.288 mg/L PBTK NA 50% Human Human +DTXSID3023132 Css NA 4.757 mg/L PBTK NA 95% Human Human +DTXSID3023132 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023132 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023132 Vd NA 0.3088 L/kg 1compartment NA NA Rat Human DTXSID3023132 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023132 TK.Half.Life NA 0.7896 hours 1compartment NA NA Rat Human -DTXSID3023132 Css NA 0.2825 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023132 Css NA 1.124 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023132 Css NA 0.1676 mg/L PBTK NA 50% Rat Human -DTXSID3023132 Css NA 0.6385 mg/L PBTK NA 95% Rat Human -DTXSID3023180 Clint NA 436.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023180 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3023180 Vd NA 2.661 L/kg 1compartment NA NA Human Human -DTXSID3023180 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023180 TK.Half.Life NA 6.261 hours 1compartment NA NA Human Human -DTXSID3023180 Css NA 0.2222 mg/L 3compartmentss NA 50% Human Human -DTXSID3023180 Css NA 1.525 mg/L 3compartmentss NA 95% Human Human -DTXSID3023180 Css NA 0.1476 mg/L PBTK NA 50% Human Human -DTXSID3023180 Css NA 0.9897 mg/L PBTK NA 95% Human Human -DTXSID3023180 Clint NA 436.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023180 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3023180 Vd NA 1.989 L/kg 1compartment NA NA Rat Human -DTXSID3023180 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023180 TK.Half.Life NA 1.61 hours 1compartment NA NA Rat Human -DTXSID3023180 Css NA 0.1266 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023180 Css NA 0.6812 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023180 Css NA 0.07973 mg/L PBTK NA 50% Rat Human -DTXSID3023180 Css NA 0.412 mg/L PBTK NA 95% Rat Human +DTXSID3023132 TK.Half.Life NA 3.094 hours 1compartment NA NA Rat Human +DTXSID3023132 Css NA 0.01082 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023132 Css NA 0.04315 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023132 Css NA 0.00658 mg/L PBTK NA 50% Rat Human +DTXSID3023132 Css NA 0.02497 mg/L PBTK NA 95% Rat Human DTXSID3023188 Clint 52.96 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID3023188 Fup 0.055 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3023188 Vd NA 1.848 L/kg 1compartment NA NA Human Human DTXSID3023188 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3023188 TK.Half.Life NA 4.478 hours 1compartment NA NA Human Human -DTXSID3023188 Css NA 0.2655 mg/L 3compartmentss NA 50% Human Human -DTXSID3023188 Css NA 1.936 mg/L 3compartmentss NA 95% Human Human -DTXSID3023188 Css NA 0.1719 mg/L PBTK NA 50% Human Human -DTXSID3023188 Css NA 1.208 mg/L PBTK NA 95% Human Human +DTXSID3023188 Css NA 0.2378 mg/L 3compartmentss NA 50% Human Human +DTXSID3023188 Css NA 1.678 mg/L 3compartmentss NA 95% Human Human +DTXSID3023188 Css NA 0.1664 mg/L PBTK NA 50% Human Human +DTXSID3023188 Css NA 1.174 mg/L PBTK NA 95% Human Human DTXSID3023188 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID3023188 Fup 0.01 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID3023188 Vd NA 0.6293 L/kg 1compartment NA NA Rat Rat DTXSID3023188 Days.Css NA 36 Days PBTK NA NA Rat Rat DTXSID3023188 TK.Half.Life NA 143 hours 1compartment NA NA Rat Rat -DTXSID3023188 Css NA 29.98 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3023188 Css NA 169.5 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3023188 Css NA 19.22 mg/L PBTK NA 50% Rat Rat -DTXSID3023188 Css NA 95.01 mg/L PBTK NA 95% Rat Rat -DTXSID3023219 Clint NA 9.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023219 Fup NA 0.0968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023219 Vd NA 2.928 L/kg 1compartment NA NA Human Human +DTXSID3023188 Css NA 6.151 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3023188 Css NA 30.57 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3023188 Css NA 4.458 mg/L PBTK NA 50% Rat Rat +DTXSID3023188 Css NA 22.16 mg/L PBTK NA 95% Rat Rat +DTXSID3023211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023211 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3023211 Vd NA 3.622 L/kg 1compartment NA NA Human Human +DTXSID3023211 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023211 TK.Half.Life NA 9.449 hours 1compartment NA NA Human Human +DTXSID3023211 Css NA 0.1972 mg/L 3compartmentss NA 50% Human Human +DTXSID3023211 Css NA 1.31 mg/L 3compartmentss NA 95% Human Human +DTXSID3023211 Css NA 0.1652 mg/L PBTK NA 50% Human Human +DTXSID3023211 Css NA 1.005 mg/L PBTK NA 95% Human Human +DTXSID3023211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023211 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3023211 Vd NA 3.003 L/kg 1compartment NA NA Rat Human +DTXSID3023211 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023211 TK.Half.Life NA 2.327 hours 1compartment NA NA Rat Human +DTXSID3023211 Css NA 0.02487 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023211 Css NA 0.1356 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023211 Css NA 0.02092 mg/L PBTK NA 50% Rat Human +DTXSID3023211 Css NA 0.1092 mg/L PBTK NA 95% Rat Human +DTXSID3023213 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023213 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3023213 Vd NA 7.97 L/kg 1compartment NA NA Human Human +DTXSID3023213 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023213 TK.Half.Life NA 3.644 hours 1compartment NA NA Human Human +DTXSID3023213 Css NA 0.009502 mg/L 3compartmentss NA 50% Human Human +DTXSID3023213 Css NA 0.1522 mg/L 3compartmentss NA 95% Human Human +DTXSID3023213 Css NA 0.02025 mg/L PBTK NA 50% Human Human +DTXSID3023213 Css NA 0.1921 mg/L PBTK NA 95% Human Human +DTXSID3023213 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023213 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3023213 Vd NA 8.126 L/kg 1compartment NA NA Rat Human +DTXSID3023213 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023213 TK.Half.Life NA 1.848 hours 1compartment NA NA Rat Human +DTXSID3023213 Css NA 0.001131 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023213 Css NA 0.01497 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023213 Css NA 0.002572 mg/L PBTK NA 50% Rat Human +DTXSID3023213 Css NA 0.01824 mg/L PBTK NA 95% Rat Human +DTXSID3023215 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023215 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023215 Vd NA 0.8441 L/kg 1compartment NA NA Human Human +DTXSID3023215 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3023215 TK.Half.Life NA 15.09 hours 1compartment NA NA Human Human +DTXSID3023215 Css NA 1.647 mg/L 3compartmentss NA 50% Human Human +DTXSID3023215 Css NA 7.263 mg/L 3compartmentss NA 95% Human Human +DTXSID3023215 Css NA 1.256 mg/L PBTK NA 50% Human Human +DTXSID3023215 Css NA 4.687 mg/L PBTK NA 95% Human Human +DTXSID3023215 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023215 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023215 Vd NA 0.8437 L/kg 1compartment NA NA Rat Human +DTXSID3023215 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023215 TK.Half.Life NA 5.131 hours 1compartment NA NA Rat Human +DTXSID3023215 Css NA 0.03945 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023215 Css NA 0.2348 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023215 Css NA 0.03019 mg/L PBTK NA 50% Rat Human +DTXSID3023215 Css NA 0.1507 mg/L PBTK NA 95% Rat Human +DTXSID3023219 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023219 Fup 0.157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023219 Vd NA 2.982 L/kg 1compartment NA NA Human Human DTXSID3023219 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3023219 TK.Half.Life NA 16.22 hours 1compartment NA NA Human Human -DTXSID3023219 Css NA 0.627 mg/L 3compartmentss NA 50% Human Human -DTXSID3023219 Css NA 4.156 mg/L 3compartmentss NA 95% Human Human -DTXSID3023219 Css NA 0.4818 mg/L PBTK NA 50% Human Human -DTXSID3023219 Css NA 2.948 mg/L PBTK NA 95% Human Human -DTXSID3023219 Clint NA 9.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023219 Fup NA 0.0968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023219 Vd NA 2.441 L/kg 1compartment NA NA Rat Human -DTXSID3023219 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023219 TK.Half.Life NA 5.247 hours 1compartment NA NA Rat Human -DTXSID3023219 Css NA 0.337 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023219 Css NA 1.715 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023219 Css NA 0.2502 mg/L PBTK NA 50% Rat Human -DTXSID3023219 Css NA 1.151 mg/L PBTK NA 95% Rat Human -DTXSID3023261 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3023219 TK.Half.Life NA 20.54 hours 1compartment NA NA Human Human +DTXSID3023219 Css NA 0.7446 mg/L 3compartmentss NA 50% Human Human +DTXSID3023219 Css NA 4.593 mg/L 3compartmentss NA 95% Human Human +DTXSID3023219 Css NA 0.5262 mg/L PBTK NA 50% Human Human +DTXSID3023219 Css NA 3.153 mg/L PBTK NA 95% Human Human +DTXSID3023219 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023219 Fup 0.157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023219 Vd NA 2.245 L/kg 1compartment NA NA Rat Human +DTXSID3023219 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3023219 TK.Half.Life NA 3.666 hours 1compartment NA NA Rat Human +DTXSID3023219 Css NA 0.09487 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023219 Css NA 0.4957 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023219 Css NA 0.06645 mg/L PBTK NA 50% Rat Human +DTXSID3023219 Css NA 0.3353 mg/L PBTK NA 95% Rat Human +DTXSID3023261 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3023261 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3023261 Vd NA 0.8231 L/kg 1compartment NA NA Human Human DTXSID3023261 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3023261 TK.Half.Life NA 5.386 hours 1compartment NA NA Human Human -DTXSID3023261 Css NA 0.8356 mg/L 3compartmentss NA 50% Human Human -DTXSID3023261 Css NA 5.848 mg/L 3compartmentss NA 95% Human Human -DTXSID3023261 Css NA 0.6982 mg/L PBTK NA 50% Human Human -DTXSID3023261 Css NA 3.775 mg/L PBTK NA 95% Human Human -DTXSID3023261 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3023261 Css NA 0.8145 mg/L 3compartmentss NA 50% Human Human +DTXSID3023261 Css NA 5.305 mg/L 3compartmentss NA 95% Human Human +DTXSID3023261 Css NA 0.679 mg/L PBTK NA 50% Human Human +DTXSID3023261 Css NA 3.492 mg/L PBTK NA 95% Human Human +DTXSID3023261 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3023261 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3023261 Vd NA 0.8148 L/kg 1compartment NA NA Rat Human DTXSID3023261 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3023261 TK.Half.Life NA 1.801 hours 1compartment NA NA Rat Human -DTXSID3023261 Css NA 0.2118 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023261 Css NA 1.315 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023261 Css NA 0.1729 mg/L PBTK NA 50% Rat Human -DTXSID3023261 Css NA 0.7894 mg/L PBTK NA 95% Rat Human -DTXSID3023265 Clint NA 26.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023265 Fup NA 0.1705 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023265 Vd NA 3.063 L/kg 1compartment NA NA Human Human -DTXSID3023265 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3023265 TK.Half.Life NA 23.27 hours 1compartment NA NA Human Human -DTXSID3023265 Css NA 0.8394 mg/L 3compartmentss NA 50% Human Human -DTXSID3023265 Css NA 5.316 mg/L 3compartmentss NA 95% Human Human -DTXSID3023265 Css NA 0.5909 mg/L PBTK NA 50% Human Human -DTXSID3023265 Css NA 3.64 mg/L PBTK NA 95% Human Human -DTXSID3023265 Clint NA 26.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023265 Fup NA 0.1705 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023265 Vd NA 2.304 L/kg 1compartment NA NA Rat Human -DTXSID3023265 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3023265 TK.Half.Life NA 3.788 hours 1compartment NA NA Rat Human -DTXSID3023265 Css NA 0.4647 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023265 Css NA 2.385 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023265 Css NA 0.3137 mg/L PBTK NA 50% Rat Human -DTXSID3023265 Css NA 1.566 mg/L PBTK NA 95% Rat Human -DTXSID3023269 Clint NA 28.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023269 Fup NA 0.1702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023269 Vd NA 0.8202 L/kg 1compartment NA NA Human Human +DTXSID3023261 Css NA 0.04727 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023261 Css NA 0.2883 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023261 Css NA 0.04005 mg/L PBTK NA 50% Rat Human +DTXSID3023261 Css NA 0.1798 mg/L PBTK NA 95% Rat Human +DTXSID3023265 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023265 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023265 Vd NA 3.119 L/kg 1compartment NA NA Human Human +DTXSID3023265 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID3023265 TK.Half.Life NA 54.07 hours 1compartment NA NA Human Human +DTXSID3023265 Css NA 1.973 mg/L 3compartmentss NA 50% Human Human +DTXSID3023265 Css NA 12.87 mg/L 3compartmentss NA 95% Human Human +DTXSID3023265 Css NA 1.386 mg/L PBTK NA 50% Human Human +DTXSID3023265 Css NA 8.644 mg/L PBTK NA 95% Human Human +DTXSID3023265 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023265 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023265 Vd NA 2.339 L/kg 1compartment NA NA Rat Human +DTXSID3023265 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID3023265 TK.Half.Life NA 7.519 hours 1compartment NA NA Rat Human +DTXSID3023265 Css NA 0.2568 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023265 Css NA 1.435 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023265 Css NA 0.1784 mg/L PBTK NA 50% Rat Human +DTXSID3023265 Css NA 0.9616 mg/L PBTK NA 95% Rat Human +DTXSID3023269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023269 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023269 Vd NA 1.711 L/kg 1compartment NA NA Human Human DTXSID3023269 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023269 TK.Half.Life NA 1.307 hours 1compartment NA NA Human Human -DTXSID3023269 Css NA 0.1034 mg/L 3compartmentss NA 50% Human Human -DTXSID3023269 Css NA 0.7205 mg/L 3compartmentss NA 95% Human Human -DTXSID3023269 Css NA 0.07032 mg/L PBTK NA 50% Human Human -DTXSID3023269 Css NA 0.4627 mg/L PBTK NA 95% Human Human -DTXSID3023269 Clint NA 28.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023269 Fup NA 0.1702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023269 Vd NA 0.6876 L/kg 1compartment NA NA Rat Human +DTXSID3023269 TK.Half.Life NA 2.478 hours 1compartment NA NA Human Human +DTXSID3023269 Css NA 0.08531 mg/L 3compartmentss NA 50% Human Human +DTXSID3023269 Css NA 0.6053 mg/L 3compartmentss NA 95% Human Human +DTXSID3023269 Css NA 0.06455 mg/L PBTK NA 50% Human Human +DTXSID3023269 Css NA 0.4196 mg/L PBTK NA 95% Human Human +DTXSID3023269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023269 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023269 Vd NA 1.362 L/kg 1compartment NA NA Rat Human DTXSID3023269 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023269 TK.Half.Life NA 0.5879 hours 1compartment NA NA Rat Human -DTXSID3023269 Css NA 0.05668 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023269 Css NA 0.3021 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023269 Css NA 0.03688 mg/L PBTK NA 50% Rat Human -DTXSID3023269 Css NA 0.1875 mg/L PBTK NA 95% Rat Human -DTXSID3023340 Clint NA 32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023340 Fup NA 0.0382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023340 Vd NA 0.6716 L/kg 1compartment NA NA Human Human +DTXSID3023269 TK.Half.Life NA 0.9329 hours 1compartment NA NA Rat Human +DTXSID3023269 Css NA 0.01055 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023269 Css NA 0.05714 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023269 Css NA 0.008016 mg/L PBTK NA 50% Rat Human +DTXSID3023269 Css NA 0.0399 mg/L PBTK NA 95% Rat Human +DTXSID3023340 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023340 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023340 Vd NA 1.34 L/kg 1compartment NA NA Human Human DTXSID3023340 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023340 TK.Half.Life NA 2.613 hours 1compartment NA NA Human Human -DTXSID3023340 Css NA 0.5686 mg/L 3compartmentss NA 50% Human Human -DTXSID3023340 Css NA 5.071 mg/L 3compartmentss NA 95% Human Human -DTXSID3023340 Css NA 0.3432 mg/L PBTK NA 50% Human Human -DTXSID3023340 Css NA 2.977 mg/L PBTK NA 95% Human Human -DTXSID3023340 Clint NA 32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023340 Fup NA 0.0382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023340 Vd NA 0.5305 L/kg 1compartment NA NA Rat Human +DTXSID3023340 TK.Half.Life NA 2.777 hours 1compartment NA NA Human Human +DTXSID3023340 Css NA 0.18 mg/L 3compartmentss NA 50% Human Human +DTXSID3023340 Css NA 1.352 mg/L 3compartmentss NA 95% Human Human +DTXSID3023340 Css NA 0.1227 mg/L PBTK NA 50% Human Human +DTXSID3023340 Css NA 0.8705 mg/L PBTK NA 95% Human Human +DTXSID3023340 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023340 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023340 Vd NA 1.051 L/kg 1compartment NA NA Rat Human DTXSID3023340 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023340 TK.Half.Life NA 1.247 hours 1compartment NA NA Rat Human -DTXSID3023340 Css NA 0.3168 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023340 Css NA 2.425 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023340 Css NA 0.181 mg/L PBTK NA 50% Rat Human -DTXSID3023340 Css NA 1.351 mg/L PBTK NA 95% Rat Human +DTXSID3023340 TK.Half.Life NA 1.124 hours 1compartment NA NA Rat Human +DTXSID3023340 Css NA 0.02306 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023340 Css NA 0.13 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023340 Css NA 0.01556 mg/L PBTK NA 50% Rat Human +DTXSID3023340 Css NA 0.08217 mg/L PBTK NA 95% Rat Human DTXSID3023342 Clint 3.193 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID3023342 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3023342 Vd NA 0.8231 L/kg 1compartment NA NA Human Human DTXSID3023342 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3023342 TK.Half.Life NA 6.307 hours 1compartment NA NA Human Human -DTXSID3023342 Css NA 0.2676 mg/L 3compartmentss NA 50% Human Human -DTXSID3023342 Css NA 1.953 mg/L 3compartmentss NA 95% Human Human -DTXSID3023342 Css NA 0.255 mg/L PBTK NA 50% Human Human -DTXSID3023342 Css NA 1.405 mg/L PBTK NA 95% Human Human +DTXSID3023342 Css NA 0.557 mg/L 3compartmentss NA 50% Human Human +DTXSID3023342 Css NA 3.412 mg/L 3compartmentss NA 95% Human Human +DTXSID3023342 Css NA 0.5561 mg/L PBTK NA 50% Human Human +DTXSID3023342 Css NA 3.411 mg/L PBTK NA 95% Human Human DTXSID3023342 Clint 3.193 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID3023342 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3023342 Vd NA 2.881 L/kg 1compartment NA NA Rat Human DTXSID3023342 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3023342 TK.Half.Life NA 2.36 hours 1compartment NA NA Rat Human -DTXSID3023342 Css NA 0.05876 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023342 Css NA 0.2719 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023342 Css NA 0.05329 mg/L PBTK NA 50% Rat Human -DTXSID3023342 Css NA 0.1876 mg/L PBTK NA 95% Rat Human +DTXSID3023342 Css NA 0.001601 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023342 Css NA 0.01147 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023342 Css NA 0.00161 mg/L PBTK NA 50% Rat Human +DTXSID3023342 Css NA 0.01172 mg/L PBTK NA 95% Rat Human +DTXSID3023344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023344 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3023344 Vd NA 2.971 L/kg 1compartment NA NA Human Human +DTXSID3023344 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3023344 TK.Half.Life NA 15.88 hours 1compartment NA NA Human Human +DTXSID3023344 Css NA 0.5366 mg/L 3compartmentss NA 50% Human Human +DTXSID3023344 Css NA 3.354 mg/L 3compartmentss NA 95% Human Human +DTXSID3023344 Css NA 0.3866 mg/L PBTK NA 50% Human Human +DTXSID3023344 Css NA 2.278 mg/L PBTK NA 95% Human Human +DTXSID3023344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023344 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3023344 Vd NA 2.245 L/kg 1compartment NA NA Rat Human +DTXSID3023344 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023344 TK.Half.Life NA 3.007 hours 1compartment NA NA Rat Human +DTXSID3023344 Css NA 0.06834 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023344 Css NA 0.3525 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023344 Css NA 0.04838 mg/L PBTK NA 50% Rat Human +DTXSID3023344 Css NA 0.2414 mg/L PBTK NA 95% Rat Human +DTXSID3023390 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023390 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023390 Vd NA 2.634 L/kg 1compartment NA NA Human Human +DTXSID3023390 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023390 TK.Half.Life NA 10.65 hours 1compartment NA NA Human Human +DTXSID3023390 Css NA 0.4162 mg/L 3compartmentss NA 50% Human Human +DTXSID3023390 Css NA 2.79 mg/L 3compartmentss NA 95% Human Human +DTXSID3023390 Css NA 0.2896 mg/L PBTK NA 50% Human Human +DTXSID3023390 Css NA 1.856 mg/L PBTK NA 95% Human Human +DTXSID3023390 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023390 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023390 Vd NA 1.987 L/kg 1compartment NA NA Rat Human +DTXSID3023390 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023390 TK.Half.Life NA 2.604 hours 1compartment NA NA Rat Human +DTXSID3023390 Css NA 0.0503 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023390 Css NA 0.2561 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023390 Css NA 0.03488 mg/L PBTK NA 50% Rat Human +DTXSID3023390 Css NA 0.1718 mg/L PBTK NA 95% Rat Human DTXSID3023396 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID3023396 Fup 0.175 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID3023396 Vd NA 3.731 L/kg 1compartment NA NA Human Human DTXSID3023396 Days.Css NA 12 Days PBTK NA NA Human Human DTXSID3023396 TK.Half.Life NA 78.85 hours 1compartment NA NA Human Human -DTXSID3023396 Css NA 1.812 mg/L 3compartmentss NA 50% Human Human -DTXSID3023396 Css NA 7.965 mg/L 3compartmentss NA 95% Human Human -DTXSID3023396 Css NA 1.798 mg/L PBTK NA 50% Human Human -DTXSID3023396 Css NA 6.442 mg/L PBTK NA 95% Human Human +DTXSID3023396 Css NA 1.75 mg/L 3compartmentss NA 50% Human Human +DTXSID3023396 Css NA 7.994 mg/L 3compartmentss NA 95% Human Human +DTXSID3023396 Css NA 1.724 mg/L PBTK NA 50% Human Human +DTXSID3023396 Css NA 6.474 mg/L PBTK NA 95% Human Human DTXSID3023396 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID3023396 Fup 0.175 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID3023396 Vd NA 3.429 L/kg 1compartment NA NA Rat Human DTXSID3023396 Days.Css NA 6 Days PBTK NA NA Rat Human DTXSID3023396 TK.Half.Life NA 25.27 hours 1compartment NA NA Rat Human -DTXSID3023396 Css NA 0.74 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023396 Css NA 2.513 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023396 Css NA 0.7255 mg/L PBTK NA 50% Rat Human -DTXSID3023396 Css NA 1.862 mg/L PBTK NA 95% Rat Human -DTXSID3023398 Clint NA 2.279 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023398 Fup NA 0.5064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023398 Vd NA 3.737 L/kg 1compartment NA NA Human Human +DTXSID3023396 Css NA 0.1648 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023396 Css NA 0.5714 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023396 Css NA 0.1683 mg/L PBTK NA 50% Rat Human +DTXSID3023396 Css NA 0.4454 mg/L PBTK NA 95% Rat Human +DTXSID3023398 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023398 Fup 0.531 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023398 Vd NA 1.937 L/kg 1compartment NA NA Human Human DTXSID3023398 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023398 TK.Half.Life NA 11.64 hours 1compartment NA NA Human Human -DTXSID3023398 Css NA 0.2084 mg/L 3compartmentss NA 50% Human Human -DTXSID3023398 Css NA 1.58 mg/L 3compartmentss NA 95% Human Human -DTXSID3023398 Css NA 0.2554 mg/L PBTK NA 50% Human Human -DTXSID3023398 Css NA 1.302 mg/L PBTK NA 95% Human Human -DTXSID3023398 Clint NA 2.279 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023398 Fup NA 0.5064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023398 Vd NA 3.716 L/kg 1compartment NA NA Rat Human +DTXSID3023398 TK.Half.Life NA 3.984 hours 1compartment NA NA Human Human +DTXSID3023398 Css NA 0.1606 mg/L 3compartmentss NA 50% Human Human +DTXSID3023398 Css NA 1.152 mg/L 3compartmentss NA 95% Human Human +DTXSID3023398 Css NA 0.134 mg/L PBTK NA 50% Human Human +DTXSID3023398 Css NA 0.8096 mg/L PBTK NA 95% Human Human +DTXSID3023398 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023398 Fup 0.531 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023398 Vd NA 1.567 L/kg 1compartment NA NA Rat Human DTXSID3023398 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023398 TK.Half.Life NA 5.859 hours 1compartment NA NA Rat Human -DTXSID3023398 Css NA 0.09141 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023398 Css NA 0.6007 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023398 Css NA 0.1122 mg/L PBTK NA 50% Rat Human -DTXSID3023398 Css NA 0.4562 mg/L PBTK NA 95% Rat Human -DTXSID3023425 Clint NA 93.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3023398 TK.Half.Life NA 1.442 hours 1compartment NA NA Rat Human +DTXSID3023398 Css NA 0.01842 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023398 Css NA 0.1059 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023398 Css NA 0.01554 mg/L PBTK NA 50% Rat Human +DTXSID3023398 Css NA 0.072 mg/L PBTK NA 95% Rat Human +DTXSID3023425 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID3023425 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3023425 Vd NA 1.167 L/kg 1compartment NA NA Human Human -DTXSID3023425 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023425 TK.Half.Life NA 1.443 hours 1compartment NA NA Human Human -DTXSID3023425 Css NA 0.07479 mg/L 3compartmentss NA 50% Human Human -DTXSID3023425 Css NA 0.67 mg/L 3compartmentss NA 95% Human Human -DTXSID3023425 Css NA 0.05316 mg/L PBTK NA 50% Human Human -DTXSID3023425 Css NA 0.4289 mg/L PBTK NA 95% Human Human -DTXSID3023425 Clint NA 93.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3023425 Vd NA 1.111 L/kg 1compartment NA NA Human Human +DTXSID3023425 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3023425 TK.Half.Life NA 15.87 hours 1compartment NA NA Human Human +DTXSID3023425 Css NA 2.052 mg/L 3compartmentss NA 50% Human Human +DTXSID3023425 Css NA 13.89 mg/L 3compartmentss NA 95% Human Human +DTXSID3023425 Css NA 1.447 mg/L PBTK NA 50% Human Human +DTXSID3023425 Css NA 8.825 mg/L PBTK NA 95% Human Human +DTXSID3023425 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID3023425 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3023425 Vd NA 1.136 L/kg 1compartment NA NA Rat Human +DTXSID3023425 Vd NA 1.08 L/kg 1compartment NA NA Rat Human DTXSID3023425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023425 TK.Half.Life NA 0.752 hours 1compartment NA NA Rat Human -DTXSID3023425 Css NA 0.04282 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023425 Css NA 0.3263 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023425 Css NA 0.0287 mg/L PBTK NA 50% Rat Human -DTXSID3023425 Css NA 0.2003 mg/L PBTK NA 95% Rat Human -DTXSID3023427 Clint NA 1.409 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023427 Fup NA 0.6029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023427 Vd NA 0.6318 L/kg 1compartment NA NA Human Human +DTXSID3023425 TK.Half.Life NA 9.359 hours 1compartment NA NA Rat Human +DTXSID3023425 Css NA 0.2388 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023425 Css NA 1.3 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023425 Css NA 0.1636 mg/L PBTK NA 50% Rat Human +DTXSID3023425 Css NA 0.7852 mg/L PBTK NA 95% Rat Human +DTXSID3023427 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023427 Fup 0.412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023427 Vd NA 0.5035 L/kg 1compartment NA NA Human Human DTXSID3023427 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023427 TK.Half.Life NA 2.247 hours 1compartment NA NA Human Human -DTXSID3023427 Css NA 0.3909 mg/L 3compartmentss NA 50% Human Human -DTXSID3023427 Css NA 2.706 mg/L 3compartmentss NA 95% Human Human -DTXSID3023427 Css NA 0.3059 mg/L PBTK NA 50% Human Human -DTXSID3023427 Css NA 1.72 mg/L PBTK NA 95% Human Human -DTXSID3023427 Clint NA 1.409 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023427 Fup NA 0.6029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023427 Vd NA 0.65 L/kg 1compartment NA NA Rat Human +DTXSID3023427 TK.Half.Life NA 7.912 hours 1compartment NA NA Human Human +DTXSID3023427 Css NA 1.734 mg/L 3compartmentss NA 50% Human Human +DTXSID3023427 Css NA 7.624 mg/L 3compartmentss NA 95% Human Human +DTXSID3023427 Css NA 1.266 mg/L PBTK NA 50% Human Human +DTXSID3023427 Css NA 4.771 mg/L PBTK NA 95% Human Human +DTXSID3023427 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023427 Fup 0.412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023427 Vd NA 0.5178 L/kg 1compartment NA NA Rat Human DTXSID3023427 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023427 TK.Half.Life NA 1.17 hours 1compartment NA NA Rat Human -DTXSID3023427 Css NA 0.1569 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023427 Css NA 1.062 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023427 Css NA 0.1196 mg/L PBTK NA 50% Rat Human -DTXSID3023427 Css NA 0.6218 mg/L PBTK NA 95% Rat Human +DTXSID3023427 TK.Half.Life NA 2.771 hours 1compartment NA NA Rat Human +DTXSID3023427 Css NA 0.1112 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023427 Css NA 0.4235 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023427 Css NA 0.07976 mg/L PBTK NA 50% Rat Human +DTXSID3023427 Css NA 0.2571 mg/L PBTK NA 95% Rat Human +DTXSID3023429 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023429 Fup 0.45 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3023429 Vd NA 0.5935 L/kg 1compartment NA NA Human Human +DTXSID3023429 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023429 TK.Half.Life NA 1.101 hours 1compartment NA NA Human Human +DTXSID3023429 Css NA 0.1245 mg/L 3compartmentss NA 50% Human Human +DTXSID3023429 Css NA 0.8664 mg/L 3compartmentss NA 95% Human Human +DTXSID3023429 Css NA 0.09487 mg/L PBTK NA 50% Human Human +DTXSID3023429 Css NA 0.5978 mg/L PBTK NA 95% Human Human +DTXSID3023429 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023429 Fup 0.45 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3023429 Vd NA 0.5765 L/kg 1compartment NA NA Rat Human +DTXSID3023429 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023429 TK.Half.Life NA 0.5909 hours 1compartment NA NA Rat Human +DTXSID3023429 Css NA 0.005342 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023429 Css NA 0.04431 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023429 Css NA 0.004091 mg/L PBTK NA 50% Rat Human +DTXSID3023429 Css NA 0.02896 mg/L PBTK NA 95% Rat Human DTXSID3023471 Clint 1.64 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID3023471 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3023471 Vd NA 1.462 L/kg 1compartment NA NA Human Human +DTXSID3023471 Vd NA 1.551 L/kg 1compartment NA NA Human Human DTXSID3023471 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023471 TK.Half.Life NA 4.754 hours 1compartment NA NA Human Human -DTXSID3023471 Css NA 0.3083 mg/L 3compartmentss NA 50% Human Human -DTXSID3023471 Css NA 2.423 mg/L 3compartmentss NA 95% Human Human -DTXSID3023471 Css NA 0.2746 mg/L PBTK NA 50% Human Human -DTXSID3023471 Css NA 1.621 mg/L PBTK NA 95% Human Human +DTXSID3023471 TK.Half.Life NA 5.138 hours 1compartment NA NA Human Human +DTXSID3023471 Css NA 0.299 mg/L 3compartmentss NA 50% Human Human +DTXSID3023471 Css NA 2.214 mg/L 3compartmentss NA 95% Human Human +DTXSID3023471 Css NA 0.2706 mg/L PBTK NA 50% Human Human +DTXSID3023471 Css NA 1.493 mg/L PBTK NA 95% Human Human DTXSID3023471 Clint 1.64 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID3023471 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3023471 Vd NA 1.339 L/kg 1compartment NA NA Rat Human +DTXSID3023471 Vd NA 1.403 L/kg 1compartment NA NA Rat Human DTXSID3023471 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023471 TK.Half.Life NA 2.118 hours 1compartment NA NA Rat Human -DTXSID3023471 Css NA 0.1244 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023471 Css NA 0.9047 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023471 Css NA 0.1102 mg/L PBTK NA 50% Rat Human -DTXSID3023471 Css NA 0.5531 mg/L PBTK NA 95% Rat Human -DTXSID3023479 Clint NA 5.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3023471 TK.Half.Life NA 2.227 hours 1compartment NA NA Rat Human +DTXSID3023471 Css NA 0.02864 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023471 Css NA 0.2096 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023471 Css NA 0.0262 mg/L PBTK NA 50% Rat Human +DTXSID3023471 Css NA 0.1334 mg/L PBTK NA 95% Rat Human +DTXSID3023479 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3023479 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3023479 Vd NA 0.7056 L/kg 1compartment NA NA Human Human +DTXSID3023479 Vd NA 0.5 L/kg 1compartment NA NA Human Human DTXSID3023479 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023479 TK.Half.Life NA 0.9586 hours 1compartment NA NA Human Human -DTXSID3023479 Css NA 0.106 mg/L 3compartmentss NA 50% Human Human -DTXSID3023479 Css NA 0.9221 mg/L 3compartmentss NA 95% Human Human -DTXSID3023479 Css NA 0.0848 mg/L PBTK NA 50% Human Human -DTXSID3023479 Css NA 0.6218 mg/L PBTK NA 95% Human Human -DTXSID3023479 Clint NA 5.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3023479 TK.Half.Life NA 4.627 hours 1compartment NA NA Human Human +DTXSID3023479 Css NA 0.9958 mg/L 3compartmentss NA 50% Human Human +DTXSID3023479 Css NA 6.394 mg/L 3compartmentss NA 95% Human Human +DTXSID3023479 Css NA 0.7525 mg/L PBTK NA 50% Human Human +DTXSID3023479 Css NA 4.025 mg/L PBTK NA 95% Human Human +DTXSID3023479 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3023479 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3023479 Vd NA 0.8114 L/kg 1compartment NA NA Rat Human +DTXSID3023479 Vd NA 0.5663 L/kg 1compartment NA NA Rat Human DTXSID3023479 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023479 TK.Half.Life NA 0.4994 hours 1compartment NA NA Rat Human -DTXSID3023479 Css NA 0.04338 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023479 Css NA 0.2966 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023479 Css NA 0.03539 mg/L PBTK NA 50% Rat Human -DTXSID3023479 Css NA 0.1843 mg/L PBTK NA 95% Rat Human -DTXSID3023502 Clint NA 7.758 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023502 Fup NA 0.212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023502 Vd NA 1.589 L/kg 1compartment NA NA Human Human -DTXSID3023502 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023502 TK.Half.Life NA 5.403 hours 1compartment NA NA Human Human -DTXSID3023502 Css NA 0.3282 mg/L 3compartmentss NA 50% Human Human -DTXSID3023502 Css NA 1.937 mg/L 3compartmentss NA 95% Human Human -DTXSID3023502 Css NA 0.2371 mg/L PBTK NA 50% Human Human -DTXSID3023502 Css NA 1.315 mg/L PBTK NA 95% Human Human -DTXSID3023502 Clint NA 7.758 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023502 Fup NA 0.212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023502 Vd NA 1.249 L/kg 1compartment NA NA Rat Human -DTXSID3023502 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023502 TK.Half.Life NA 2.09 hours 1compartment NA NA Rat Human -DTXSID3023502 Css NA 0.1725 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023502 Css NA 0.735 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023502 Css NA 0.1196 mg/L PBTK NA 50% Rat Human -DTXSID3023502 Css NA 0.4603 mg/L PBTK NA 95% Rat Human -DTXSID3023550 Clint NA 19.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3023479 TK.Half.Life NA 1.469 hours 1compartment NA NA Rat Human +DTXSID3023479 Css NA 0.02252 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023479 Css NA 0.153 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023479 Css NA 0.01682 mg/L PBTK NA 50% Rat Human +DTXSID3023479 Css NA 0.09526 mg/L PBTK NA 95% Rat Human +DTXSID3023502 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023502 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023502 Vd NA 1.651 L/kg 1compartment NA NA Human Human +DTXSID3023502 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID3023502 TK.Half.Life NA 65.33 hours 1compartment NA NA Human Human +DTXSID3023502 Css NA 4.294 mg/L 3compartmentss NA 50% Human Human +DTXSID3023502 Css NA 14.71 mg/L 3compartmentss NA 95% Human Human +DTXSID3023502 Css NA 3.166 mg/L PBTK NA 50% Human Human +DTXSID3023502 Css NA 9.565 mg/L PBTK NA 95% Human Human +DTXSID3023502 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023502 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023502 Vd NA 1.3 L/kg 1compartment NA NA Rat Human +DTXSID3023502 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3023502 TK.Half.Life NA 13.63 hours 1compartment NA NA Rat Human +DTXSID3023502 Css NA 0.2718 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023502 Css NA 0.7919 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023502 Css NA 0.1981 mg/L PBTK NA 50% Rat Human +DTXSID3023502 Css NA 0.4965 mg/L PBTK NA 95% Rat Human +DTXSID3023550 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3023550 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3023550 Vd NA 2.857 L/kg 1compartment NA NA Human Human -DTXSID3023550 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023550 TK.Half.Life NA 10.72 hours 1compartment NA NA Human Human -DTXSID3023550 Css NA 0.417 mg/L 3compartmentss NA 50% Human Human -DTXSID3023550 Css NA 3.068 mg/L 3compartmentss NA 95% Human Human -DTXSID3023550 Css NA 0.3087 mg/L PBTK NA 50% Human Human -DTXSID3023550 Css NA 2.111 mg/L PBTK NA 95% Human Human -DTXSID3023550 Clint NA 19.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3023550 Vd NA 3.107 L/kg 1compartment NA NA Human Human +DTXSID3023550 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID3023550 TK.Half.Life NA 69.65 hours 1compartment NA NA Human Human +DTXSID3023550 Css NA 2.62 mg/L 3compartmentss NA 50% Human Human +DTXSID3023550 Css NA 17.42 mg/L 3compartmentss NA 95% Human Human +DTXSID3023550 Css NA 1.82 mg/L PBTK NA 50% Human Human +DTXSID3023550 Css NA 11.7 mg/L PBTK NA 95% Human Human +DTXSID3023550 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3023550 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3023550 Vd NA 2.344 L/kg 1compartment NA NA Rat Human -DTXSID3023550 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023550 TK.Half.Life NA 3.438 hours 1compartment NA NA Rat Human -DTXSID3023550 Css NA 0.2287 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023550 Css NA 1.432 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023550 Css NA 0.1632 mg/L PBTK NA 50% Rat Human -DTXSID3023550 Css NA 0.9586 mg/L PBTK NA 95% Rat Human +DTXSID3023550 Vd NA 2.328 L/kg 1compartment NA NA Rat Human +DTXSID3023550 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID3023550 TK.Half.Life NA 9.669 hours 1compartment NA NA Rat Human +DTXSID3023550 Css NA 0.341 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023550 Css NA 1.942 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023550 Css NA 0.2348 mg/L PBTK NA 50% Rat Human +DTXSID3023550 Css NA 1.292 mg/L PBTK NA 95% Rat Human DTXSID3023552 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID3023552 Fup 0.015 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3023552 Vd NA 0.3674 L/kg 1compartment NA NA Human Human -DTXSID3023552 Days.Css NA 36 Days PBTK NA NA Human Human -DTXSID3023552 TK.Half.Life NA 161.2 hours 1compartment NA NA Human Human -DTXSID3023552 Css NA 76.83 mg/L 3compartmentss NA 50% Human Human -DTXSID3023552 Css NA 464.1 mg/L 3compartmentss NA 95% Human Human -DTXSID3023552 Css NA 43.66 mg/L PBTK NA 50% Human Human -DTXSID3023552 Css NA 267.4 mg/L PBTK NA 95% Human Human +DTXSID3023552 Vd NA 2.187 L/kg 1compartment NA NA Human Human +DTXSID3023552 Days.Css NA 572 Days PBTK NA NA Human Human +DTXSID3023552 TK.Half.Life NA 2164 hours 1compartment NA NA Human Human +DTXSID3023552 Css NA 163 mg/L 3compartmentss NA 50% Human Human +DTXSID3023552 Css NA 644.5 mg/L 3compartmentss NA 95% Human Human +DTXSID3023552 Css NA 89.65 mg/L PBTK NA 50% Human Human +DTXSID3023552 Css NA 354.5 mg/L PBTK NA 95% Human Human DTXSID3023552 Clint 79.58 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID3023552 Fup 0.015 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID3023552 Vd NA 0.3022 L/kg 1compartment NA NA Rat Rat +DTXSID3023552 Vd NA 1.631 L/kg 1compartment NA NA Rat Rat DTXSID3023552 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID3023552 TK.Half.Life NA 0.7579 hours 1compartment NA NA Rat Rat -DTXSID3023552 Css NA 0.35 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3023552 Css NA 2.961 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3023552 Css NA 0.1864 mg/L PBTK NA 50% Rat Rat -DTXSID3023552 Css NA 1.585 mg/L PBTK NA 95% Rat Rat -DTXSID3023554 Clint NA 15.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023554 Fup NA 0.0259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023554 Vd NA 1.985 L/kg 1compartment NA NA Human Human -DTXSID3023554 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3023554 TK.Half.Life NA 21.9 hours 1compartment NA NA Human Human -DTXSID3023554 Css NA 1.67 mg/L 3compartmentss NA 50% Human Human -DTXSID3023554 Css NA 13.39 mg/L 3compartmentss NA 95% Human Human -DTXSID3023554 Css NA 1.093 mg/L PBTK NA 50% Human Human -DTXSID3023554 Css NA 8.265 mg/L PBTK NA 95% Human Human -DTXSID3023554 Clint NA 15.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023554 Fup NA 0.0259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023554 Vd NA 1.523 L/kg 1compartment NA NA Rat Human -DTXSID3023554 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3023554 TK.Half.Life NA 7.694 hours 1compartment NA NA Rat Human -DTXSID3023554 Css NA 0.927 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023554 Css NA 5.978 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023554 Css NA 0.572 mg/L PBTK NA 50% Rat Human -DTXSID3023554 Css NA 3.449 mg/L PBTK NA 95% Rat Human -DTXSID3023681 Clint NA 1028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023681 Fup NA 0.039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023681 Vd NA 1.388 L/kg 1compartment NA NA Human Human +DTXSID3023552 TK.Half.Life NA 2.863 hours 1compartment NA NA Rat Rat +DTXSID3023552 Css NA 0.07625 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3023552 Css NA 0.5177 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3023552 Css NA 0.04343 mg/L PBTK NA 50% Rat Rat +DTXSID3023552 Css NA 0.2948 mg/L PBTK NA 95% Rat Rat +DTXSID3023554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023554 Fup 0.0645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023554 Vd NA 2.299 L/kg 1compartment NA NA Human Human +DTXSID3023554 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023554 TK.Half.Life NA 12.03 hours 1compartment NA NA Human Human +DTXSID3023554 Css NA 0.625 mg/L 3compartmentss NA 50% Human Human +DTXSID3023554 Css NA 4.259 mg/L 3compartmentss NA 95% Human Human +DTXSID3023554 Css NA 0.4228 mg/L PBTK NA 50% Human Human +DTXSID3023554 Css NA 2.775 mg/L PBTK NA 95% Human Human +DTXSID3023554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023554 Fup 0.0645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023554 Vd NA 1.726 L/kg 1compartment NA NA Rat Human +DTXSID3023554 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023554 TK.Half.Life NA 3.452 hours 1compartment NA NA Rat Human +DTXSID3023554 Css NA 0.0815 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023554 Css NA 0.4389 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023554 Css NA 0.05381 mg/L PBTK NA 50% Rat Human +DTXSID3023554 Css NA 0.2843 mg/L PBTK NA 95% Rat Human +DTXSID3023556 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023556 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023556 Vd NA 3.109 L/kg 1compartment NA NA Human Human +DTXSID3023556 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID3023556 TK.Half.Life NA 86.72 hours 1compartment NA NA Human Human +DTXSID3023556 Css NA 3.294 mg/L 3compartmentss NA 50% Human Human +DTXSID3023556 Css NA 21.76 mg/L 3compartmentss NA 95% Human Human +DTXSID3023556 Css NA 2.29 mg/L PBTK NA 50% Human Human +DTXSID3023556 Css NA 14.9 mg/L PBTK NA 95% Human Human +DTXSID3023556 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023556 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023556 Vd NA 2.329 L/kg 1compartment NA NA Rat Human +DTXSID3023556 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID3023556 TK.Half.Life NA 11.88 hours 1compartment NA NA Rat Human +DTXSID3023556 Css NA 0.432 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023556 Css NA 2.316 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023556 Css NA 0.2958 mg/L PBTK NA 50% Rat Human +DTXSID3023556 Css NA 1.568 mg/L PBTK NA 95% Rat Human +DTXSID3023631 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023631 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3023631 Vd NA 0.3701 L/kg 1compartment NA NA Human Human +DTXSID3023631 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3023631 TK.Half.Life NA 19.6 hours 1compartment NA NA Human Human +DTXSID3023631 Css NA 10.34 mg/L 3compartmentss NA 50% Human Human +DTXSID3023631 Css NA 89.52 mg/L 3compartmentss NA 95% Human Human +DTXSID3023631 Css NA 5.684 mg/L PBTK NA 50% Human Human +DTXSID3023631 Css NA 49.24 mg/L PBTK NA 95% Human Human +DTXSID3023631 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023631 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3023631 Vd NA 0.3387 L/kg 1compartment NA NA Rat Human +DTXSID3023631 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3023631 TK.Half.Life NA 11.49 hours 1compartment NA NA Rat Human +DTXSID3023631 Css NA 1.194 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023631 Css NA 8.295 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023631 Css NA 0.68 mg/L PBTK NA 50% Rat Human +DTXSID3023631 Css NA 4.721 mg/L PBTK NA 95% Rat Human +DTXSID3023639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023639 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3023639 Vd NA 0.3832 L/kg 1compartment NA NA Human Human +DTXSID3023639 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023639 TK.Half.Life NA 2.914 hours 1compartment NA NA Human Human +DTXSID3023639 Css NA 0.875 mg/L 3compartmentss NA 50% Human Human +DTXSID3023639 Css NA 5.655 mg/L 3compartmentss NA 95% Human Human +DTXSID3023639 Css NA 0.7345 mg/L PBTK NA 50% Human Human +DTXSID3023639 Css NA 4.749 mg/L PBTK NA 95% Human Human +DTXSID3023639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023639 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3023639 Vd NA 0.3587 L/kg 1compartment NA NA Rat Human +DTXSID3023639 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023639 TK.Half.Life NA 1.693 hours 1compartment NA NA Rat Human +DTXSID3023639 Css NA 0.1009 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023639 Css NA 0.4803 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023639 Css NA 0.08769 mg/L PBTK NA 50% Rat Human +DTXSID3023639 Css NA 0.4178 mg/L PBTK NA 95% Rat Human +DTXSID3023681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023681 Fup 0.0683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023681 Vd NA 1.534 L/kg 1compartment NA NA Human Human DTXSID3023681 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023681 TK.Half.Life NA 1.376 hours 1compartment NA NA Human Human -DTXSID3023681 Css NA 0.01788 mg/L 3compartmentss NA 50% Human Human -DTXSID3023681 Css NA 0.1644 mg/L 3compartmentss NA 95% Human Human -DTXSID3023681 Css NA 0.01125 mg/L PBTK NA 50% Human Human -DTXSID3023681 Css NA 0.09979 mg/L PBTK NA 95% Human Human -DTXSID3023681 Clint NA 1028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023681 Fup NA 0.039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023681 Vd NA 1.04 L/kg 1compartment NA NA Rat Human +DTXSID3023681 TK.Half.Life NA 5.781 hours 1compartment NA NA Human Human +DTXSID3023681 Css NA 0.4216 mg/L 3compartmentss NA 50% Human Human +DTXSID3023681 Css NA 2.914 mg/L 3compartmentss NA 95% Human Human +DTXSID3023681 Css NA 0.2762 mg/L PBTK NA 50% Human Human +DTXSID3023681 Css NA 1.827 mg/L PBTK NA 95% Human Human +DTXSID3023681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023681 Fup 0.0683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023681 Vd NA 1.161 L/kg 1compartment NA NA Rat Human DTXSID3023681 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023681 TK.Half.Life NA 0.4643 hours 1compartment NA NA Rat Human -DTXSID3023681 Css NA 0.01021 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023681 Css NA 0.0796 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023681 Css NA 0.006042 mg/L PBTK NA 50% Rat Human -DTXSID3023681 Css NA 0.04532 mg/L PBTK NA 95% Rat Human +DTXSID3023681 TK.Half.Life NA 2.212 hours 1compartment NA NA Rat Human +DTXSID3023681 Css NA 0.05517 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023681 Css NA 0.2921 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023681 Css NA 0.03522 mg/L PBTK NA 50% Rat Human +DTXSID3023681 Css NA 0.1828 mg/L PBTK NA 95% Rat Human DTXSID3023685 Clint 22 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3023685 Fup 0.0133 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3023685 Vd NA 0.2148 L/kg 1compartment NA NA Human Human +DTXSID3023685 Vd NA 0.4463 L/kg 1compartment NA NA Human Human DTXSID3023685 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023685 TK.Half.Life NA 2.922 hours 1compartment NA NA Human Human -DTXSID3023685 Css NA 1.604 mg/L 3compartmentss NA 50% Human Human -DTXSID3023685 Css NA 11.04 mg/L 3compartmentss NA 95% Human Human -DTXSID3023685 Css NA 0.9401 mg/L PBTK NA 50% Human Human -DTXSID3023685 Css NA 6.474 mg/L PBTK NA 95% Human Human +DTXSID3023685 TK.Half.Life NA 5.663 hours 1compartment NA NA Human Human +DTXSID3023685 Css NA 1.43 mg/L 3compartmentss NA 50% Human Human +DTXSID3023685 Css NA 10.04 mg/L 3compartmentss NA 95% Human Human +DTXSID3023685 Css NA 0.859 mg/L PBTK NA 50% Human Human +DTXSID3023685 Css NA 5.911 mg/L PBTK NA 95% Human Human DTXSID3023685 Clint 22 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3023685 Fup 0.0133 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3023685 Vd NA 0.1985 L/kg 1compartment NA NA Rat Human +DTXSID3023685 Vd NA 0.3506 L/kg 1compartment NA NA Rat Human DTXSID3023685 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023685 TK.Half.Life NA 1.793 hours 1compartment NA NA Rat Human -DTXSID3023685 Css NA 0.9082 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023685 Css NA 4.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023685 Css NA 0.4986 mg/L PBTK NA 50% Rat Human -DTXSID3023685 Css NA 2.513 mg/L PBTK NA 95% Rat Human -DTXSID3023687 Clint NA 179.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3023685 TK.Half.Life NA 2.899 hours 1compartment NA NA Rat Human +DTXSID3023685 Css NA 0.1887 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023685 Css NA 1.035 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023685 Css NA 0.1097 mg/L PBTK NA 50% Rat Human +DTXSID3023685 Css NA 0.5907 mg/L PBTK NA 95% Rat Human +DTXSID3023687 Clint 30 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID3023687 Fup 0.037 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3023687 Vd NA 3.272 L/kg 1compartment NA NA Human Human +DTXSID3023687 Vd NA 3.247 L/kg 1compartment NA NA Human Human DTXSID3023687 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023687 TK.Half.Life NA 2.971 hours 1compartment NA NA Human Human -DTXSID3023687 Css NA 0.01862 mg/L 3compartmentss NA 50% Human Human -DTXSID3023687 Css NA 0.1288 mg/L 3compartmentss NA 95% Human Human -DTXSID3023687 Css NA 0.01372 mg/L PBTK NA 50% Human Human -DTXSID3023687 Css NA 0.09005 mg/L PBTK NA 95% Human Human -DTXSID3023687 Clint NA 179.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3023687 TK.Half.Life NA 5.291 hours 1compartment NA NA Human Human +DTXSID3023687 Css NA 0.1092 mg/L 3compartmentss NA 50% Human Human +DTXSID3023687 Css NA 0.8295 mg/L 3compartmentss NA 95% Human Human +DTXSID3023687 Css NA 0.0821 mg/L PBTK NA 50% Human Human +DTXSID3023687 Css NA 0.5817 mg/L PBTK NA 95% Human Human +DTXSID3023687 Clint 30 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID3023687 Fup 0.037 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3023687 Vd NA 2.57 L/kg 1compartment NA NA Rat Human +DTXSID3023687 Vd NA 2.61 L/kg 1compartment NA NA Rat Human DTXSID3023687 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023687 TK.Half.Life NA 0.94 hours 1compartment NA NA Rat Human -DTXSID3023687 Css NA 0.01036 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023687 Css NA 0.0583 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023687 Css NA 0.007344 mg/L PBTK NA 50% Rat Human -DTXSID3023687 Css NA 0.03907 mg/L PBTK NA 95% Rat Human -DTXSID3023712 Clint NA 395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3023687 TK.Half.Life NA 1.472 hours 1compartment NA NA Rat Human +DTXSID3023687 Css NA 0.01423 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023687 Css NA 0.08828 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023687 Css NA 0.01063 mg/L PBTK NA 50% Rat Human +DTXSID3023687 Css NA 0.06197 mg/L PBTK NA 95% Rat Human +DTXSID3023712 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3023712 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3023712 Vd NA 1.644 L/kg 1compartment NA NA Human Human DTXSID3023712 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3023712 TK.Half.Life NA 0.8847 hours 1compartment NA NA Human Human -DTXSID3023712 Css NA 0.001188 mg/L 3compartmentss NA 50% Human Human -DTXSID3023712 Css NA 0.01326 mg/L 3compartmentss NA 95% Human Human -DTXSID3023712 Css NA 0.001199 mg/L PBTK NA 50% Human Human -DTXSID3023712 Css NA 0.01049 mg/L PBTK NA 95% Human Human -DTXSID3023712 Clint NA 395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3023712 TK.Half.Life NA 2.604 hours 1compartment NA NA Human Human +DTXSID3023712 Css NA 0.09886 mg/L 3compartmentss NA 50% Human Human +DTXSID3023712 Css NA 0.6445 mg/L 3compartmentss NA 95% Human Human +DTXSID3023712 Css NA 0.1012 mg/L PBTK NA 50% Human Human +DTXSID3023712 Css NA 0.6625 mg/L PBTK NA 95% Human Human +DTXSID3023712 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3023712 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3023712 Vd NA 1.639 L/kg 1compartment NA NA Rat Human DTXSID3023712 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023712 TK.Half.Life NA 0.3898 hours 1compartment NA NA Rat Human -DTXSID3023712 Css NA 0.0009922 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023712 Css NA 0.009166 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023712 Css NA 0.0009692 mg/L PBTK NA 50% Rat Human -DTXSID3023712 Css NA 0.007194 mg/L PBTK NA 95% Rat Human -DTXSID3023716 Clint NA 3.031 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023716 Fup NA 0.0414 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023716 Vd NA 1.238 L/kg 1compartment NA NA Human Human -DTXSID3023716 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3023716 TK.Half.Life NA 34.52 hours 1compartment NA NA Human Human -DTXSID3023716 Css NA 4.752 mg/L 3compartmentss NA 50% Human Human -DTXSID3023716 Css NA 31.84 mg/L 3compartmentss NA 95% Human Human -DTXSID3023716 Css NA 2.987 mg/L PBTK NA 50% Human Human -DTXSID3023716 Css NA 19.09 mg/L PBTK NA 95% Human Human -DTXSID3023716 Clint NA 3.031 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023716 Fup NA 0.0414 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023716 Vd NA 0.9285 L/kg 1compartment NA NA Rat Human -DTXSID3023716 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3023716 TK.Half.Life NA 13.18 hours 1compartment NA NA Rat Human -DTXSID3023716 Css NA 2.362 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023716 Css NA 12.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023716 Css NA 1.392 mg/L PBTK NA 50% Rat Human -DTXSID3023716 Css NA 6.769 mg/L PBTK NA 95% Rat Human +DTXSID3023712 TK.Half.Life NA 1.455 hours 1compartment NA NA Rat Human +DTXSID3023712 Css NA 0.01092 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023712 Css NA 0.0548 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023712 Css NA 0.01165 mg/L PBTK NA 50% Rat Human +DTXSID3023712 Css NA 0.05847 mg/L PBTK NA 95% Rat Human +DTXSID3023714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023714 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3023714 Vd NA 1.005 L/kg 1compartment NA NA Human Human +DTXSID3023714 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023714 TK.Half.Life NA 4.077 hours 1compartment NA NA Human Human +DTXSID3023714 Css NA 0.5375 mg/L 3compartmentss NA 50% Human Human +DTXSID3023714 Css NA 4.688 mg/L 3compartmentss NA 95% Human Human +DTXSID3023714 Css NA 0.3466 mg/L PBTK NA 50% Human Human +DTXSID3023714 Css NA 2.895 mg/L PBTK NA 95% Human Human +DTXSID3023714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023714 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3023714 Vd NA 0.8946 L/kg 1compartment NA NA Rat Human +DTXSID3023714 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023714 TK.Half.Life NA 2.206 hours 1compartment NA NA Rat Human +DTXSID3023714 Css NA 0.07035 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023714 Css NA 0.4721 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023714 Css NA 0.04404 mg/L PBTK NA 50% Rat Human +DTXSID3023714 Css NA 0.2796 mg/L PBTK NA 95% Rat Human +DTXSID3023716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023716 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023716 Vd NA 1.967 L/kg 1compartment NA NA Human Human +DTXSID3023716 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023716 TK.Half.Life NA 5.563 hours 1compartment NA NA Human Human +DTXSID3023716 Css NA 0.2847 mg/L 3compartmentss NA 50% Human Human +DTXSID3023716 Css NA 2.094 mg/L 3compartmentss NA 95% Human Human +DTXSID3023716 Css NA 0.1954 mg/L PBTK NA 50% Human Human +DTXSID3023716 Css NA 1.339 mg/L PBTK NA 95% Human Human +DTXSID3023716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023716 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023716 Vd NA 1.492 L/kg 1compartment NA NA Rat Human +DTXSID3023716 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3023716 TK.Half.Life NA 1.865 hours 1compartment NA NA Rat Human +DTXSID3023716 Css NA 0.03742 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023716 Css NA 0.2034 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023716 Css NA 0.02518 mg/L PBTK NA 50% Rat Human +DTXSID3023716 Css NA 0.1309 mg/L PBTK NA 95% Rat Human DTXSID3023718 Clint 4.3 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human -DTXSID3023718 Fup NA 0.1282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023718 Vd NA 3.341 L/kg 1compartment NA NA Human Human +DTXSID3023718 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023718 Vd NA 3.774 L/kg 1compartment NA NA Human Human DTXSID3023718 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3023718 TK.Half.Life NA 25.96 hours 1compartment NA NA Human Human -DTXSID3023718 Css NA 0.833 mg/L 3compartmentss NA 50% Human Human -DTXSID3023718 Css NA 5.438 mg/L 3compartmentss NA 95% Human Human -DTXSID3023718 Css NA 0.7026 mg/L PBTK NA 50% Human Human -DTXSID3023718 Css NA 4.024 mg/L PBTK NA 95% Human Human +DTXSID3023718 TK.Half.Life NA 24.8 hours 1compartment NA NA Human Human +DTXSID3023718 Css NA 0.5496 mg/L 3compartmentss NA 50% Human Human +DTXSID3023718 Css NA 3.23 mg/L 3compartmentss NA 95% Human Human +DTXSID3023718 Css NA 0.512 mg/L PBTK NA 50% Human Human +DTXSID3023718 Css NA 2.681 mg/L PBTK NA 95% Human Human DTXSID3023718 Clint 4.3 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human -DTXSID3023718 Fup NA 0.1282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023718 Vd NA 2.918 L/kg 1compartment NA NA Rat Human +DTXSID3023718 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023718 Vd NA 3.31 L/kg 1compartment NA NA Rat Human DTXSID3023718 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3023718 TK.Half.Life NA 8.741 hours 1compartment NA NA Rat Human -DTXSID3023718 Css NA 0.4244 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023718 Css NA 1.964 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023718 Css NA 0.35 mg/L PBTK NA 50% Rat Human -DTXSID3023718 Css NA 1.407 mg/L PBTK NA 95% Rat Human +DTXSID3023718 TK.Half.Life NA 7.33 hours 1compartment NA NA Rat Human +DTXSID3023718 Css NA 0.06514 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023718 Css NA 0.2638 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023718 Css NA 0.06182 mg/L PBTK NA 50% Rat Human +DTXSID3023718 Css NA 0.2263 mg/L PBTK NA 95% Rat Human +DTXSID30237569 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30237569 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30237569 Vd NA 2.964 L/kg 1compartment NA NA Human Human +DTXSID30237569 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30237569 TK.Half.Life NA 6.46 hours 1compartment NA NA Human Human +DTXSID30237569 Css NA 0.1358 mg/L 3compartmentss NA 50% Human Human +DTXSID30237569 Css NA 1.041 mg/L 3compartmentss NA 95% Human Human +DTXSID30237569 Css NA 0.1482 mg/L PBTK NA 50% Human Human +DTXSID30237569 Css NA 0.8722 mg/L PBTK NA 95% Human Human +DTXSID30237569 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30237569 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30237569 Vd NA 2.996 L/kg 1compartment NA NA Rat Human +DTXSID30237569 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30237569 TK.Half.Life NA 3.862 hours 1compartment NA NA Rat Human +DTXSID30237569 Css NA 0.01566 mg/L 3compartmentss NA 50% Rat Human +DTXSID30237569 Css NA 0.08899 mg/L 3compartmentss NA 95% Rat Human +DTXSID30237569 Css NA 0.0176 mg/L PBTK NA 50% Rat Human +DTXSID30237569 Css NA 0.07505 mg/L PBTK NA 95% Rat Human DTXSID3023764 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3023764 Fup NA 0.0233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3023764 Vd NA 6.145 L/kg 1compartment NA NA Human Human DTXSID3023764 Days.Css NA 18 Days PBTK NA NA Human Human DTXSID3023764 TK.Half.Life NA 111 hours 1compartment NA NA Human Human -DTXSID3023764 Css NA 1.627 mg/L 3compartmentss NA 50% Human Human -DTXSID3023764 Css NA 9.318 mg/L 3compartmentss NA 95% Human Human -DTXSID3023764 Css NA 1.439 mg/L PBTK NA 50% Human Human -DTXSID3023764 Css NA 8.003 mg/L PBTK NA 95% Human Human +DTXSID3023764 Css NA 1.57 mg/L 3compartmentss NA 50% Human Human +DTXSID3023764 Css NA 9.497 mg/L 3compartmentss NA 95% Human Human +DTXSID3023764 Css NA 1.397 mg/L PBTK NA 50% Human Human +DTXSID3023764 Css NA 8.081 mg/L PBTK NA 95% Human Human DTXSID3023764 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3023764 Fup NA 0.0233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3023764 Vd NA 4.735 L/kg 1compartment NA NA Rat Human DTXSID3023764 Days.Css NA 11 Days PBTK NA NA Rat Human DTXSID3023764 TK.Half.Life NA 15.37 hours 1compartment NA NA Rat Human -DTXSID3023764 Css NA 0.8952 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023764 Css NA 3.713 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023764 Css NA 0.7796 mg/L PBTK NA 50% Rat Human -DTXSID3023764 Css NA 3.312 mg/L PBTK NA 95% Rat Human +DTXSID3023764 Css NA 0.2036 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023764 Css NA 0.9365 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023764 Css NA 0.1837 mg/L PBTK NA 50% Rat Human +DTXSID3023764 Css NA 0.8787 mg/L PBTK NA 95% Rat Human DTXSID3023897 Clint 14.59 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3023897 Fup 0.1142 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3023897 Vd NA 1.123 L/kg 1compartment NA NA Human Human DTXSID3023897 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3023897 TK.Half.Life NA 3.399 hours 1compartment NA NA Human Human -DTXSID3023897 Css NA 0.327 mg/L 3compartmentss NA 50% Human Human -DTXSID3023897 Css NA 2.563 mg/L 3compartmentss NA 95% Human Human -DTXSID3023897 Css NA 0.253 mg/L PBTK NA 50% Human Human -DTXSID3023897 Css NA 1.731 mg/L PBTK NA 95% Human Human +DTXSID3023897 Css NA 0.2875 mg/L 3compartmentss NA 50% Human Human +DTXSID3023897 Css NA 2.073 mg/L 3compartmentss NA 95% Human Human +DTXSID3023897 Css NA 0.2412 mg/L PBTK NA 50% Human Human +DTXSID3023897 Css NA 1.74 mg/L PBTK NA 95% Human Human DTXSID3023897 Clint 11.44 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID3023897 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID3023897 Css NA 4.514 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3023897 Css NA 40.62 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3023974 Clint NA 0.2427 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023974 Fup NA 0.3319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3023974 Vd NA 0.7402 L/kg 1compartment NA NA Human Human -DTXSID3023974 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3023974 TK.Half.Life NA 10.57 hours 1compartment NA NA Human Human -DTXSID3023974 Css NA 1.558 mg/L 3compartmentss NA 50% Human Human -DTXSID3023974 Css NA 6.417 mg/L 3compartmentss NA 95% Human Human -DTXSID3023974 Css NA 1.151 mg/L PBTK NA 50% Human Human -DTXSID3023974 Css NA 4.122 mg/L PBTK NA 95% Human Human -DTXSID3023974 Clint NA 0.2427 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023974 Fup NA 0.3319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3023974 Vd NA 0.6827 L/kg 1compartment NA NA Rat Human +DTXSID3023897 Css NA 0.9275 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3023897 Css NA 6.776 mg/L 3compartmentss NA 95% Rat Rat +DTXSID30239341 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30239341 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30239341 Vd NA 3.464 L/kg 1compartment NA NA Human Human +DTXSID30239341 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID30239341 TK.Half.Life NA 70.46 hours 1compartment NA NA Human Human +DTXSID30239341 Css NA 1.259 mg/L 3compartmentss NA 50% Human Human +DTXSID30239341 Css NA 6.7 mg/L 3compartmentss NA 95% Human Human +DTXSID30239341 Css NA 1.606 mg/L PBTK NA 50% Human Human +DTXSID30239341 Css NA 5.663 mg/L PBTK NA 95% Human Human +DTXSID30239341 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30239341 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30239341 Vd NA 5.14 L/kg 1compartment NA NA Rat Human +DTXSID30239341 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID30239341 TK.Half.Life NA 21.03 hours 1compartment NA NA Rat Human +DTXSID30239341 Css NA 0.0349 mg/L 3compartmentss NA 50% Rat Human +DTXSID30239341 Css NA 0.3388 mg/L 3compartmentss NA 95% Rat Human +DTXSID30239341 Css NA 0.06304 mg/L PBTK NA 50% Rat Human +DTXSID30239341 Css NA 0.2836 mg/L PBTK NA 95% Rat Human +DTXSID3023974 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023974 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3023974 Vd NA 0.5779 L/kg 1compartment NA NA Human Human +DTXSID3023974 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3023974 TK.Half.Life NA 1.948 hours 1compartment NA NA Human Human +DTXSID3023974 Css NA 0.3342 mg/L 3compartmentss NA 50% Human Human +DTXSID3023974 Css NA 1.929 mg/L 3compartmentss NA 95% Human Human +DTXSID3023974 Css NA 0.227 mg/L PBTK NA 50% Human Human +DTXSID3023974 Css NA 1.235 mg/L PBTK NA 95% Human Human +DTXSID3023974 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023974 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3023974 Vd NA 0.5317 L/kg 1compartment NA NA Rat Human DTXSID3023974 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3023974 TK.Half.Life NA 3.813 hours 1compartment NA NA Rat Human -DTXSID3023974 Css NA 0.5062 mg/L 3compartmentss NA 50% Rat Human -DTXSID3023974 Css NA 1.835 mg/L 3compartmentss NA 95% Rat Human -DTXSID3023974 Css NA 0.3578 mg/L PBTK NA 50% Rat Human -DTXSID3023974 Css NA 1.094 mg/L PBTK NA 95% Rat Human -DTXSID3024100 Clint NA 180.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024100 Fup NA 0.1505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024100 Vd NA 0.9934 L/kg 1compartment NA NA Human Human +DTXSID3023974 TK.Half.Life NA 1.04 hours 1compartment NA NA Rat Human +DTXSID3023974 Css NA 0.03908 mg/L 3compartmentss NA 50% Rat Human +DTXSID3023974 Css NA 0.171 mg/L 3compartmentss NA 95% Rat Human +DTXSID3023974 Css NA 0.0263 mg/L PBTK NA 50% Rat Human +DTXSID3023974 Css NA 0.1046 mg/L PBTK NA 95% Rat Human +DTXSID3024100 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024100 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024100 Vd NA 1.392 L/kg 1compartment NA NA Human Human DTXSID3024100 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024100 TK.Half.Life NA 0.9607 hours 1compartment NA NA Human Human -DTXSID3024100 Css NA 0.0218 mg/L 3compartmentss NA 50% Human Human -DTXSID3024100 Css NA 0.1827 mg/L 3compartmentss NA 95% Human Human -DTXSID3024100 Css NA 0.01472 mg/L PBTK NA 50% Human Human -DTXSID3024100 Css NA 0.1147 mg/L PBTK NA 95% Human Human -DTXSID3024100 Clint NA 180.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024100 Fup NA 0.1505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024100 Vd NA 0.8032 L/kg 1compartment NA NA Rat Human +DTXSID3024100 TK.Half.Life NA 2.264 hours 1compartment NA NA Human Human +DTXSID3024100 Css NA 0.105 mg/L 3compartmentss NA 50% Human Human +DTXSID3024100 Css NA 0.7493 mg/L 3compartmentss NA 95% Human Human +DTXSID3024100 Css NA 0.07548 mg/L PBTK NA 50% Human Human +DTXSID3024100 Css NA 0.503 mg/L PBTK NA 95% Human Human +DTXSID3024100 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024100 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024100 Vd NA 1.113 L/kg 1compartment NA NA Rat Human DTXSID3024100 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024100 TK.Half.Life NA 0.3612 hours 1compartment NA NA Rat Human -DTXSID3024100 Css NA 0.01256 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024100 Css NA 0.08353 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024100 Css NA 0.007982 mg/L PBTK NA 50% Rat Human -DTXSID3024100 Css NA 0.04963 mg/L PBTK NA 95% Rat Human +DTXSID3024100 TK.Half.Life NA 0.9116 hours 1compartment NA NA Rat Human +DTXSID3024100 Css NA 0.01327 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024100 Css NA 0.07247 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024100 Css NA 0.00954 mg/L PBTK NA 50% Rat Human +DTXSID3024100 Css NA 0.0488 mg/L PBTK NA 95% Rat Human DTXSID3024102 Clint 62.11 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3024102 Fup 0.04138 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3024102 Vd NA 0.5289 L/kg 1compartment NA NA Human Human DTXSID3024102 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3024102 TK.Half.Life NA 1.246 hours 1compartment NA NA Human Human -DTXSID3024102 Css NA 0.2742 mg/L 3compartmentss NA 50% Human Human -DTXSID3024102 Css NA 2.567 mg/L 3compartmentss NA 95% Human Human -DTXSID3024102 Css NA 0.1658 mg/L PBTK NA 50% Human Human +DTXSID3024102 Css NA 0.2636 mg/L 3compartmentss NA 50% Human Human +DTXSID3024102 Css NA 2.524 mg/L 3compartmentss NA 95% Human Human +DTXSID3024102 Css NA 0.16 mg/L PBTK NA 50% Human Human DTXSID3024102 Css NA 1.503 mg/L PBTK NA 95% Human Human DTXSID3024102 Clint 62.11 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3024102 Fup 0.04138 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3024102 Vd NA 0.4212 L/kg 1compartment NA NA Rat Human DTXSID3024102 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3024102 TK.Half.Life NA 0.5757 hours 1compartment NA NA Rat Human -DTXSID3024102 Css NA 0.1578 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024102 Css NA 1.165 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024102 Css NA 0.09 mg/L PBTK NA 50% Rat Human -DTXSID3024102 Css NA 0.6445 mg/L PBTK NA 95% Rat Human +DTXSID3024102 Css NA 0.03522 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024102 Css NA 0.2791 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024102 Css NA 0.02068 mg/L PBTK NA 50% Rat Human +DTXSID3024102 Css NA 0.161 mg/L PBTK NA 95% Rat Human DTXSID3024104 Clint 8.064 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3024104 Fup 0.01409 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3024104 Vd NA 5.226 L/kg 1compartment NA NA Human Human DTXSID3024104 Days.Css NA 71 Days PBTK NA NA Human Human DTXSID3024104 TK.Half.Life NA 310.4 hours 1compartment NA NA Human Human -DTXSID3024104 Css NA 2.651 mg/L 3compartmentss NA 50% Human Human -DTXSID3024104 Css NA 21.5 mg/L 3compartmentss NA 95% Human Human -DTXSID3024104 Css NA 5.31 mg/L PBTK NA 50% Human Human -DTXSID3024104 Css NA 33.78 mg/L PBTK NA 95% Human Human +DTXSID3024104 Css NA 2.597 mg/L 3compartmentss NA 50% Human Human +DTXSID3024104 Css NA 20.55 mg/L 3compartmentss NA 95% Human Human +DTXSID3024104 Css NA 5.244 mg/L PBTK NA 50% Human Human +DTXSID3024104 Css NA 33.2 mg/L PBTK NA 95% Human Human DTXSID3024104 Clint 8.064 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3024104 Fup 0.01409 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3024104 Vd NA 4.718 L/kg 1compartment NA NA Rat Human DTXSID3024104 Days.Css NA 46 Days PBTK NA NA Rat Human DTXSID3024104 TK.Half.Life NA 56.22 hours 1compartment NA NA Rat Human -DTXSID3024104 Css NA 1.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024104 Css NA 8.472 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024104 Css NA 2.867 mg/L PBTK NA 50% Rat Human -DTXSID3024104 Css NA 14.22 mg/L PBTK NA 95% Rat Human -DTXSID3024108 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024108 Fup NA 0.0297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024108 Vd NA 1.537 L/kg 1compartment NA NA Human Human -DTXSID3024108 Days.Css NA 119 Days PBTK NA NA Human Human -DTXSID3024108 TK.Half.Life NA 488.1 hours 1compartment NA NA Human Human -DTXSID3024108 Css NA 49.86 mg/L 3compartmentss NA 50% Human Human -DTXSID3024108 Css NA 244.6 mg/L 3compartmentss NA 95% Human Human -DTXSID3024108 Css NA 31.38 mg/L PBTK NA 50% Human Human -DTXSID3024108 Css NA 146.3 mg/L PBTK NA 95% Human Human -DTXSID3024108 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024108 Fup NA 0.0297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024108 Vd NA 1.145 L/kg 1compartment NA NA Rat Human -DTXSID3024108 Days.Css NA 27 Days PBTK NA NA Rat Human -DTXSID3024108 TK.Half.Life NA 94.27 hours 1compartment NA NA Rat Human -DTXSID3024108 Css NA 13.81 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024108 Css NA 58.17 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024108 Css NA 8.176 mg/L PBTK NA 50% Rat Human -DTXSID3024108 Css NA 32.18 mg/L PBTK NA 95% Rat Human +DTXSID3024104 Css NA 0.3048 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024104 Css NA 2.045 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024104 Css NA 0.6674 mg/L PBTK NA 50% Rat Human +DTXSID3024104 Css NA 3.505 mg/L PBTK NA 95% Rat Human +DTXSID3024108 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024108 Fup 0.0895 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024108 Vd NA 2.27 L/kg 1compartment NA NA Human Human +DTXSID3024108 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3024108 TK.Half.Life NA 9.278 hours 1compartment NA NA Human Human +DTXSID3024108 Css NA 0.461 mg/L 3compartmentss NA 50% Human Human +DTXSID3024108 Css NA 3.134 mg/L 3compartmentss NA 95% Human Human +DTXSID3024108 Css NA 0.314 mg/L PBTK NA 50% Human Human +DTXSID3024108 Css NA 2.038 mg/L PBTK NA 95% Human Human +DTXSID3024108 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024108 Fup 0.0895 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024108 Vd NA 1.711 L/kg 1compartment NA NA Rat Human +DTXSID3024108 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3024108 TK.Half.Life NA 2.735 hours 1compartment NA NA Rat Human +DTXSID3024108 Css NA 0.05974 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024108 Css NA 0.3262 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024108 Css NA 0.03994 mg/L PBTK NA 50% Rat Human +DTXSID3024108 Css NA 0.2092 mg/L PBTK NA 95% Rat Human DTXSID3024152 Clint 2.457 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3024152 Fup 0.1513 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3024152 Vd NA 0.8454 L/kg 1compartment NA NA Human Human +DTXSID3024152 Vd NA 0.319 L/kg 1compartment NA NA Human Human DTXSID3024152 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024152 TK.Half.Life NA 7.804 hours 1compartment NA NA Human Human -DTXSID3024152 Css NA 1.25 mg/L 3compartmentss NA 50% Human Human -DTXSID3024152 Css NA 6.961 mg/L 3compartmentss NA 95% Human Human -DTXSID3024152 Css NA 0.8333 mg/L PBTK NA 50% Human Human -DTXSID3024152 Css NA 4.275 mg/L PBTK NA 95% Human Human +DTXSID3024152 TK.Half.Life NA 2.873 hours 1compartment NA NA Human Human +DTXSID3024152 Css NA 1.151 mg/L 3compartmentss NA 50% Human Human +DTXSID3024152 Css NA 6.781 mg/L 3compartmentss NA 95% Human Human +DTXSID3024152 Css NA 0.7374 mg/L PBTK NA 50% Human Human +DTXSID3024152 Css NA 4.075 mg/L PBTK NA 95% Human Human DTXSID3024152 Clint 2.457 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3024152 Fup 0.1513 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID3024152 Vd NA 0.7 L/kg 1compartment NA NA Rat Human +DTXSID3024152 Vd NA 0.3155 L/kg 1compartment NA NA Rat Human DTXSID3024152 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024152 TK.Half.Life NA 3.473 hours 1compartment NA NA Rat Human -DTXSID3024152 Css NA 0.5896 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024152 Css NA 2.538 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024152 Css NA 0.3723 mg/L PBTK NA 50% Rat Human -DTXSID3024152 Css NA 1.465 mg/L PBTK NA 95% Rat Human +DTXSID3024152 TK.Half.Life NA 1.6 hours 1compartment NA NA Rat Human +DTXSID3024152 Css NA 0.07052 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024152 Css NA 0.395 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024152 Css NA 0.04386 mg/L PBTK NA 50% Rat Human +DTXSID3024152 Css NA 0.2291 mg/L PBTK NA 95% Rat Human +DTXSID30241525 Clint 2.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30241525 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30241525 Vd NA 1.512 L/kg 1compartment NA NA Human Human +DTXSID30241525 Days.Css NA 24 Days PBTK NA NA Human Human +DTXSID30241525 TK.Half.Life NA 121.8 hours 1compartment NA NA Human Human +DTXSID30241525 Css NA 13.43 mg/L 3compartmentss NA 50% Human Human +DTXSID30241525 Css NA 90.96 mg/L 3compartmentss NA 95% Human Human +DTXSID30241525 Css NA 8.368 mg/L PBTK NA 50% Human Human +DTXSID30241525 Css NA 54.66 mg/L PBTK NA 95% Human Human +DTXSID30241525 Clint 2.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30241525 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30241525 Vd NA 1.118 L/kg 1compartment NA NA Rat Human +DTXSID30241525 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID30241525 TK.Half.Life NA 42.76 hours 1compartment NA NA Rat Human +DTXSID30241525 Css NA 1.564 mg/L 3compartmentss NA 50% Rat Human +DTXSID30241525 Css NA 8.617 mg/L 3compartmentss NA 95% Rat Human +DTXSID30241525 Css NA 0.946 mg/L PBTK NA 50% Rat Human +DTXSID30241525 Css NA 4.94 mg/L PBTK NA 95% Rat Human DTXSID3024154 Clint 11.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3024154 Fup NA 0.0716 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024154 Vd NA 0.415 L/kg 1compartment NA NA Human Human +DTXSID3024154 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024154 Vd NA 0.2749 L/kg 1compartment NA NA Human Human DTXSID3024154 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024154 TK.Half.Life NA 2.147 hours 1compartment NA NA Human Human -DTXSID3024154 Css NA 0.6758 mg/L 3compartmentss NA 50% Human Human -DTXSID3024154 Css NA 4.464 mg/L 3compartmentss NA 95% Human Human -DTXSID3024154 Css NA 0.4208 mg/L PBTK NA 50% Human Human -DTXSID3024154 Css NA 2.695 mg/L PBTK NA 95% Human Human +DTXSID3024154 TK.Half.Life NA 3.618 hours 1compartment NA NA Human Human +DTXSID3024154 Css NA 2.284 mg/L 3compartmentss NA 50% Human Human +DTXSID3024154 Css NA 20.74 mg/L 3compartmentss NA 95% Human Human +DTXSID3024154 Css NA 1.365 mg/L PBTK NA 50% Human Human +DTXSID3024154 Css NA 12.23 mg/L PBTK NA 95% Human Human DTXSID3024154 Clint 11.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID3024154 Fup NA 0.0716 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024154 Vd NA 0.361 L/kg 1compartment NA NA Rat Human +DTXSID3024154 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024154 Vd NA 0.2441 L/kg 1compartment NA NA Rat Human DTXSID3024154 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024154 TK.Half.Life NA 1.156 hours 1compartment NA NA Rat Human -DTXSID3024154 Css NA 0.3726 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024154 Css NA 1.795 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024154 Css NA 0.2178 mg/L PBTK NA 50% Rat Human -DTXSID3024154 Css NA 1.014 mg/L PBTK NA 95% Rat Human +DTXSID3024154 TK.Half.Life NA 2.082 hours 1compartment NA NA Rat Human +DTXSID3024154 Css NA 0.2943 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024154 Css NA 2.069 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024154 Css NA 0.1693 mg/L PBTK NA 50% Rat Human +DTXSID3024154 Css NA 1.162 mg/L PBTK NA 95% Rat Human DTXSID3024235 Clint 6.959 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3024235 Fup 0.02893 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3024235 Vd NA 2.065 L/kg 1compartment NA NA Human Human DTXSID3024235 Days.Css NA 6 Days PBTK NA NA Human Human DTXSID3024235 TK.Half.Life NA 46.96 hours 1compartment NA NA Human Human -DTXSID3024235 Css NA 3.567 mg/L 3compartmentss NA 50% Human Human -DTXSID3024235 Css NA 24.64 mg/L 3compartmentss NA 95% Human Human -DTXSID3024235 Css NA 2.314 mg/L PBTK NA 50% Human Human -DTXSID3024235 Css NA 15.14 mg/L PBTK NA 95% Human Human +DTXSID3024235 Css NA 3.138 mg/L 3compartmentss NA 50% Human Human +DTXSID3024235 Css NA 21.63 mg/L 3compartmentss NA 95% Human Human +DTXSID3024235 Css NA 2.294 mg/L PBTK NA 50% Human Human +DTXSID3024235 Css NA 15.81 mg/L PBTK NA 95% Human Human DTXSID3024235 Clint 5.002 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID3024235 Fup 0.07926 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID3024235 Vd NA 1.974 L/kg 1compartment NA NA Rat Rat DTXSID3024235 Days.Css NA 4 Days PBTK NA NA Rat Rat DTXSID3024235 TK.Half.Life NA 12.21 hours 1compartment NA NA Rat Rat -DTXSID3024235 Css NA 1.701 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3024235 Css NA 6.416 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3024235 Css NA 0.9898 mg/L PBTK NA 50% Rat Rat -DTXSID3024235 Css NA 3.638 mg/L PBTK NA 95% Rat Rat +DTXSID3024235 Css NA 0.3069 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3024235 Css NA 1.171 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3024235 Css NA 0.2323 mg/L PBTK NA 50% Rat Rat +DTXSID3024235 Css NA 0.8869 mg/L PBTK NA 95% Rat Rat DTXSID3024239 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3024239 Fup 0.00364 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3024239 Vd NA 2.313 L/kg 1compartment NA NA Human Human -DTXSID3024239 Days.Css NA 3020 Days PBTK NA NA Human Human +DTXSID3024239 Days.Css NA 3015 Days PBTK NA NA Human Human DTXSID3024239 TK.Half.Life NA 11000 hours 1compartment NA NA Human Human -DTXSID3024239 Css NA 711.3 mg/L 3compartmentss NA 50% Human Human -DTXSID3024239 Css NA 2713 mg/L 3compartmentss NA 95% Human Human -DTXSID3024239 Css NA 429.8 mg/L PBTK NA 50% Human Human -DTXSID3024239 Css NA 1579 mg/L PBTK NA 95% Human Human +DTXSID3024239 Css NA 650.3 mg/L 3compartmentss NA 50% Human Human +DTXSID3024239 Css NA 2318 mg/L 3compartmentss NA 95% Human Human +DTXSID3024239 Css NA 418.6 mg/L PBTK NA 50% Human Human +DTXSID3024239 Css NA 1492 mg/L PBTK NA 95% Human Human DTXSID3024239 Clint 7.264 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID3024239 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID3024239 Css NA 6.294 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3024239 Css NA 35.39 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3024239 Css NA 1.246 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3024239 Css NA 7.116 mg/L 3compartmentss NA 95% Rat Rat DTXSID3024287 Clint 2.351 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3024287 Fup 0.2895 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3024287 Vd NA 0.8576 L/kg 1compartment NA NA Human Human -DTXSID3024287 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024287 TK.Half.Life NA 4.443 hours 1compartment NA NA Human Human -DTXSID3024287 Css NA 0.5494 mg/L 3compartmentss NA 50% Human Human -DTXSID3024287 Css NA 2.703 mg/L 3compartmentss NA 95% Human Human -DTXSID3024287 Css NA 0.4034 mg/L PBTK NA 50% Human Human -DTXSID3024287 Css NA 1.769 mg/L PBTK NA 95% Human Human +DTXSID3024287 Vd NA 684.8 L/kg 1compartment NA NA Human Human +DTXSID3024287 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID3024287 TK.Half.Life NA 182700 hours 1compartment NA NA Human Human +DTXSID3024287 Css NA 0.1408 mg/L 3compartmentss NA 50% Human Human +DTXSID3024287 Css NA 0.9586 mg/L 3compartmentss NA 95% Human Human +DTXSID3024287 Css NA 15 mg/L PBTK NA 50% Human Human +DTXSID3024287 Css NA 90.33 mg/L PBTK NA 95% Human Human DTXSID3024287 Clint 2.351 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3024287 Fup 0.2895 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID3024287 Vd NA 0.7529 L/kg 1compartment NA NA Rat Human -DTXSID3024287 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024287 TK.Half.Life NA 2.077 hours 1compartment NA NA Rat Human -DTXSID3024287 Css NA 0.2533 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024287 Css NA 1.013 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024287 Css NA 0.1773 mg/L PBTK NA 50% Rat Human -DTXSID3024287 Css NA 0.6105 mg/L PBTK NA 95% Rat Human +DTXSID3024287 Vd NA 622.8 L/kg 1compartment NA NA Rat Human +DTXSID3024287 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID3024287 TK.Half.Life NA 27670 hours 1compartment NA NA Rat Human +DTXSID3024287 Css NA 0.001856 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024287 Css NA 0.01353 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024287 Css NA 0.2122 mg/L PBTK NA 50% Rat Human +DTXSID3024287 Css NA 1.481 mg/L PBTK NA 95% Rat Human DTXSID3024289 Clint 6.18 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3024289 Fup 0.02415 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3024289 Vd NA 8.577 L/kg 1compartment NA NA Human Human DTXSID3024289 Days.Css NA 120 Days PBTK NA NA Human Human DTXSID3024289 TK.Half.Life NA 546.2 hours 1compartment NA NA Human Human -DTXSID3024289 Css NA 9.684 mg/L 3compartmentss NA 50% Human Human -DTXSID3024289 Css NA 57.33 mg/L 3compartmentss NA 95% Human Human -DTXSID3024289 Css NA 5.742 mg/L PBTK NA 50% Human Human -DTXSID3024289 Css NA 33.29 mg/L PBTK NA 95% Human Human +DTXSID3024289 Css NA 7.384 mg/L 3compartmentss NA 50% Human Human +DTXSID3024289 Css NA 45.95 mg/L 3compartmentss NA 95% Human Human +DTXSID3024289 Css NA 5.564 mg/L PBTK NA 50% Human Human +DTXSID3024289 Css NA 34.62 mg/L PBTK NA 95% Human Human DTXSID3024289 Clint 18.85 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID3024289 Fup 0.05707 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID3024289 Vd NA 8.566 L/kg 1compartment NA NA Rat Rat DTXSID3024289 Days.Css NA 25 Days PBTK NA NA Rat Rat DTXSID3024289 TK.Half.Life NA 34.06 hours 1compartment NA NA Rat Rat -DTXSID3024289 Css NA 1.721 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3024289 Css NA 9.073 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3024289 Css NA 0.9402 mg/L PBTK NA 50% Rat Rat -DTXSID3024289 Css NA 4.908 mg/L PBTK NA 95% Rat Rat +DTXSID3024289 Css NA 0.2797 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3024289 Css NA 1.531 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3024289 Css NA 0.2182 mg/L PBTK NA 50% Rat Rat +DTXSID3024289 Css NA 1.194 mg/L PBTK NA 95% Rat Rat DTXSID3024316 Clint 5.282 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3024316 Fup 0.4172 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3024316 Vd NA 1.327 L/kg 1compartment NA NA Human Human DTXSID3024316 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3024316 TK.Half.Life NA 3.094 hours 1compartment NA NA Human Human -DTXSID3024316 Css NA 0.1952 mg/L 3compartmentss NA 50% Human Human -DTXSID3024316 Css NA 1.245 mg/L 3compartmentss NA 95% Human Human -DTXSID3024316 Css NA 0.1553 mg/L PBTK NA 50% Human Human -DTXSID3024316 Css NA 0.8566 mg/L PBTK NA 95% Human Human +DTXSID3024316 Css NA 0.1903 mg/L 3compartmentss NA 50% Human Human +DTXSID3024316 Css NA 1.208 mg/L 3compartmentss NA 95% Human Human +DTXSID3024316 Css NA 0.151 mg/L PBTK NA 50% Human Human +DTXSID3024316 Css NA 0.8535 mg/L PBTK NA 95% Human Human DTXSID3024316 Clint 5.282 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3024316 Fup 0.4172 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3024316 Vd NA 1.12 L/kg 1compartment NA NA Rat Human DTXSID3024316 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3024316 TK.Half.Life NA 1.346 hours 1compartment NA NA Rat Human -DTXSID3024316 Css NA 0.09816 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024316 Css NA 0.4686 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024316 Css NA 0.0754 mg/L PBTK NA 50% Rat Human -DTXSID3024316 Css NA 0.3041 mg/L PBTK NA 95% Rat Human -DTXSID3024318 Clint NA 30.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024318 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024318 Vd NA 2.473 L/kg 1compartment NA NA Human Human -DTXSID3024318 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024318 TK.Half.Life NA 9.796 hours 1compartment NA NA Human Human -DTXSID3024318 Css NA 0.4502 mg/L 3compartmentss NA 50% Human Human -DTXSID3024318 Css NA 3.064 mg/L 3compartmentss NA 95% Human Human -DTXSID3024318 Css NA 0.3073 mg/L PBTK NA 50% Human Human -DTXSID3024318 Css NA 2.028 mg/L PBTK NA 95% Human Human -DTXSID3024318 Clint NA 30.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024318 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024318 Vd NA 1.862 L/kg 1compartment NA NA Rat Human +DTXSID3024316 Css NA 0.02175 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024316 Css NA 0.1085 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024316 Css NA 0.01744 mg/L PBTK NA 50% Rat Human +DTXSID3024316 Css NA 0.07351 mg/L PBTK NA 95% Rat Human +DTXSID3024318 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024318 Fup 0.041 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024318 Vd NA 2.095 L/kg 1compartment NA NA Human Human +DTXSID3024318 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3024318 TK.Half.Life NA 13.55 hours 1compartment NA NA Human Human +DTXSID3024318 Css NA 0.892 mg/L 3compartmentss NA 50% Human Human +DTXSID3024318 Css NA 6.846 mg/L 3compartmentss NA 95% Human Human +DTXSID3024318 Css NA 0.5842 mg/L PBTK NA 50% Human Human +DTXSID3024318 Css NA 4.33 mg/L PBTK NA 95% Human Human +DTXSID3024318 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024318 Fup 0.041 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024318 Vd NA 1.568 L/kg 1compartment NA NA Rat Human DTXSID3024318 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024318 TK.Half.Life NA 2.637 hours 1compartment NA NA Rat Human -DTXSID3024318 Css NA 0.2538 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024318 Css NA 1.356 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024318 Css NA 0.1642 mg/L PBTK NA 50% Rat Human -DTXSID3024318 Css NA 0.8614 mg/L PBTK NA 95% Rat Human +DTXSID3024318 TK.Half.Life NA 4.245 hours 1compartment NA NA Rat Human +DTXSID3024318 Css NA 0.1151 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024318 Css NA 0.709 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024318 Css NA 0.07382 mg/L PBTK NA 50% Rat Human +DTXSID3024318 Css NA 0.4369 mg/L PBTK NA 95% Rat Human DTXSID3024364 Clint NA 12.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3024364 Fup NA 0.4924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3024364 Vd NA 1.674 L/kg 1compartment NA NA Human Human DTXSID3024364 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3024364 TK.Half.Life NA 2.272 hours 1compartment NA NA Human Human -DTXSID3024364 Css NA 0.08476 mg/L 3compartmentss NA 50% Human Human -DTXSID3024364 Css NA 0.6358 mg/L 3compartmentss NA 95% Human Human -DTXSID3024364 Css NA 0.07036 mg/L PBTK NA 50% Human Human -DTXSID3024364 Css NA 0.4586 mg/L PBTK NA 95% Human Human +DTXSID3024364 Css NA 0.06789 mg/L 3compartmentss NA 50% Human Human +DTXSID3024364 Css NA 0.558 mg/L 3compartmentss NA 95% Human Human +DTXSID3024364 Css NA 0.05601 mg/L PBTK NA 50% Human Human +DTXSID3024364 Css NA 0.4 mg/L PBTK NA 95% Human Human DTXSID3024364 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID3024364 Fup 0.026 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID3024364 Vd NA 0.3142 L/kg 1compartment NA NA Rat Rat DTXSID3024364 Days.Css NA 4 Days PBTK NA NA Rat Rat DTXSID3024364 TK.Half.Life NA 26.75 hours 1compartment NA NA Rat Rat -DTXSID3024364 Css NA 12.29 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3024364 Css NA 62.97 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3024364 Css NA 6.821 mg/L PBTK NA 50% Rat Rat -DTXSID3024364 Css NA 34.19 mg/L PBTK NA 95% Rat Rat +DTXSID3024364 Css NA 0.6748 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3024364 Css NA 5.505 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3024364 Css NA 0.381 mg/L PBTK NA 50% Rat Rat +DTXSID3024364 Css NA 3.072 mg/L PBTK NA 95% Rat Rat DTXSID3024368 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3024368 Fup 1 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3024368 Vd NA 1.248 L/kg 1compartment NA NA Human Human +DTXSID3024368 Vd NA 0.8098 L/kg 1compartment NA NA Human Human DTXSID3024368 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024368 TK.Half.Life NA 8.13 hours 1compartment NA NA Human Human -DTXSID3024368 Css NA 0.7595 mg/L 3compartmentss NA 50% Human Human -DTXSID3024368 Css NA 5.327 mg/L 3compartmentss NA 95% Human Human -DTXSID3024368 Css NA 0.6983 mg/L PBTK NA 50% Human Human -DTXSID3024368 Css NA 3.676 mg/L PBTK NA 95% Human Human +DTXSID3024368 TK.Half.Life NA 5.239 hours 1compartment NA NA Human Human +DTXSID3024368 Css NA 0.7984 mg/L 3compartmentss NA 50% Human Human +DTXSID3024368 Css NA 5.596 mg/L 3compartmentss NA 95% Human Human +DTXSID3024368 Css NA 0.6753 mg/L PBTK NA 50% Human Human +DTXSID3024368 Css NA 3.68 mg/L PBTK NA 95% Human Human DTXSID3024368 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3024368 Fup 1 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3024368 Vd NA 1.262 L/kg 1compartment NA NA Rat Human +DTXSID3024368 Vd NA 0.8629 L/kg 1compartment NA NA Rat Human DTXSID3024368 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024368 TK.Half.Life NA 2.787 hours 1compartment NA NA Rat Human -DTXSID3024368 Css NA 0.1907 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024368 Css NA 1.276 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024368 Css NA 0.1726 mg/L PBTK NA 50% Rat Human -DTXSID3024368 Css NA 0.7909 mg/L PBTK NA 95% Rat Human -DTXSID3024441 Clint NA 5.776 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024441 Fup NA 0.244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024441 Vd NA 0.8954 L/kg 1compartment NA NA Human Human +DTXSID3024368 TK.Half.Life NA 1.902 hours 1compartment NA NA Rat Human +DTXSID3024368 Css NA 0.04683 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024368 Css NA 0.2899 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024368 Css NA 0.04014 mg/L PBTK NA 50% Rat Human +DTXSID3024368 Css NA 0.1813 mg/L PBTK NA 95% Rat Human +DTXSID3024441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024441 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024441 Vd NA 1.076 L/kg 1compartment NA NA Human Human DTXSID3024441 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024441 TK.Half.Life NA 2.889 hours 1compartment NA NA Human Human -DTXSID3024441 Css NA 0.3174 mg/L 3compartmentss NA 50% Human Human -DTXSID3024441 Css NA 1.865 mg/L 3compartmentss NA 95% Human Human -DTXSID3024441 Css NA 0.2265 mg/L PBTK NA 50% Human Human -DTXSID3024441 Css NA 1.225 mg/L PBTK NA 95% Human Human -DTXSID3024441 Clint NA 5.776 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024441 Fup NA 0.244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024441 Vd NA 0.7675 L/kg 1compartment NA NA Rat Human +DTXSID3024441 TK.Half.Life NA 1.569 hours 1compartment NA NA Human Human +DTXSID3024441 Css NA 0.08496 mg/L 3compartmentss NA 50% Human Human +DTXSID3024441 Css NA 0.6121 mg/L 3compartmentss NA 95% Human Human +DTXSID3024441 Css NA 0.0615 mg/L PBTK NA 50% Human Human +DTXSID3024441 Css NA 0.4167 mg/L PBTK NA 95% Human Human +DTXSID3024441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024441 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024441 Vd NA 0.8977 L/kg 1compartment NA NA Rat Human DTXSID3024441 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024441 TK.Half.Life NA 1.384 hours 1compartment NA NA Rat Human -DTXSID3024441 Css NA 0.1598 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024441 Css NA 0.7008 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024441 Css NA 0.1096 mg/L PBTK NA 50% Rat Human -DTXSID3024441 Css NA 0.4291 mg/L PBTK NA 95% Rat Human -DTXSID3024449 Clint NA 0.9251 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024449 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024449 Vd NA 0.8417 L/kg 1compartment NA NA Human Human +DTXSID3024441 TK.Half.Life NA 0.6816 hours 1compartment NA NA Rat Human +DTXSID3024441 Css NA 0.01076 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024441 Css NA 0.05653 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024441 Css NA 0.007766 mg/L PBTK NA 50% Rat Human +DTXSID3024441 Css NA 0.03834 mg/L PBTK NA 95% Rat Human +DTXSID3024449 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024449 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024449 Vd NA 0.6845 L/kg 1compartment NA NA Human Human DTXSID3024449 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024449 TK.Half.Life NA 2.33 hours 1compartment NA NA Human Human -DTXSID3024449 Css NA 0.3274 mg/L 3compartmentss NA 50% Human Human -DTXSID3024449 Css NA 2.385 mg/L 3compartmentss NA 95% Human Human -DTXSID3024449 Css NA 0.2786 mg/L PBTK NA 50% Human Human -DTXSID3024449 Css NA 1.554 mg/L PBTK NA 95% Human Human -DTXSID3024449 Clint NA 0.9251 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024449 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024449 Vd NA 0.8707 L/kg 1compartment NA NA Rat Human +DTXSID3024449 TK.Half.Life NA 6.245 hours 1compartment NA NA Human Human +DTXSID3024449 Css NA 0.9266 mg/L 3compartmentss NA 50% Human Human +DTXSID3024449 Css NA 5.867 mg/L 3compartmentss NA 95% Human Human +DTXSID3024449 Css NA 0.7496 mg/L PBTK NA 50% Human Human +DTXSID3024449 Css NA 3.759 mg/L PBTK NA 95% Human Human +DTXSID3024449 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024449 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024449 Vd NA 0.7068 L/kg 1compartment NA NA Rat Human DTXSID3024449 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024449 TK.Half.Life NA 1.141 hours 1compartment NA NA Rat Human -DTXSID3024449 Css NA 0.1194 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024449 Css NA 0.7533 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024449 Css NA 0.1007 mg/L PBTK NA 50% Rat Human -DTXSID3024449 Css NA 0.4618 mg/L PBTK NA 95% Rat Human -DTXSID3024491 Clint NA 1.777 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024491 Fup NA 0.2384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024491 Vd NA 0.7641 L/kg 1compartment NA NA Human Human +DTXSID3024449 TK.Half.Life NA 2.196 hours 1compartment NA NA Rat Human +DTXSID3024449 Css NA 0.01782 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024449 Css NA 0.144 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024449 Css NA 0.01376 mg/L PBTK NA 50% Rat Human +DTXSID3024449 Css NA 0.0908 mg/L PBTK NA 95% Rat Human +DTXSID3024491 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024491 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024491 Vd NA 0.5776 L/kg 1compartment NA NA Human Human DTXSID3024491 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024491 TK.Half.Life NA 5.7 hours 1compartment NA NA Human Human -DTXSID3024491 Css NA 0.8318 mg/L 3compartmentss NA 50% Human Human -DTXSID3024491 Css NA 4.095 mg/L 3compartmentss NA 95% Human Human -DTXSID3024491 Css NA 0.5868 mg/L PBTK NA 50% Human Human -DTXSID3024491 Css NA 2.588 mg/L PBTK NA 95% Human Human -DTXSID3024491 Clint NA 1.777 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024491 Fup NA 0.2384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024491 Vd NA 0.6722 L/kg 1compartment NA NA Rat Human +DTXSID3024491 TK.Half.Life NA 1.123 hours 1compartment NA NA Human Human +DTXSID3024491 Css NA 0.1659 mg/L 3compartmentss NA 50% Human Human +DTXSID3024491 Css NA 1.305 mg/L 3compartmentss NA 95% Human Human +DTXSID3024491 Css NA 0.1082 mg/L PBTK NA 50% Human Human +DTXSID3024491 Css NA 0.8064 mg/L PBTK NA 95% Human Human +DTXSID3024491 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024491 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024491 Vd NA 0.5113 L/kg 1compartment NA NA Rat Human DTXSID3024491 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024491 TK.Half.Life NA 2.619 hours 1compartment NA NA Rat Human -DTXSID3024491 Css NA 0.374 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024491 Css NA 1.364 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024491 Css NA 0.2534 mg/L PBTK NA 50% Rat Human -DTXSID3024491 Css NA 0.8081 mg/L PBTK NA 95% Rat Human -DTXSID3024497 Clint NA 0.3782 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024497 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024497 Vd NA 1.003 L/kg 1compartment NA NA Human Human +DTXSID3024491 TK.Half.Life NA 0.5608 hours 1compartment NA NA Rat Human +DTXSID3024491 Css NA 0.0211 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024491 Css NA 0.1316 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024491 Css NA 0.01354 mg/L PBTK NA 50% Rat Human +DTXSID3024491 Css NA 0.07942 mg/L PBTK NA 95% Rat Human +DTXSID3024497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024497 Fup 0.475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024497 Vd NA 0.6409 L/kg 1compartment NA NA Human Human DTXSID3024497 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024497 TK.Half.Life NA 4.116 hours 1compartment NA NA Human Human -DTXSID3024497 Css NA 0.4756 mg/L 3compartmentss NA 50% Human Human -DTXSID3024497 Css NA 3.337 mg/L 3compartmentss NA 95% Human Human -DTXSID3024497 Css NA 0.4224 mg/L PBTK NA 50% Human Human -DTXSID3024497 Css NA 2.2 mg/L PBTK NA 95% Human Human -DTXSID3024497 Clint NA 0.3782 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024497 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024497 Vd NA 1.005 L/kg 1compartment NA NA Rat Human +DTXSID3024497 TK.Half.Life NA 0.6608 hours 1compartment NA NA Human Human +DTXSID3024497 Css NA 0.033 mg/L 3compartmentss NA 50% Human Human +DTXSID3024497 Css NA 0.324 mg/L 3compartmentss NA 95% Human Human +DTXSID3024497 Css NA 0.02516 mg/L PBTK NA 50% Human Human +DTXSID3024497 Css NA 0.2158 mg/L PBTK NA 95% Human Human +DTXSID3024497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024497 Fup 0.475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024497 Vd NA 0.6394 L/kg 1compartment NA NA Rat Human DTXSID3024497 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024497 TK.Half.Life NA 1.717 hours 1compartment NA NA Rat Human -DTXSID3024497 Css NA 0.1515 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024497 Css NA 1.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024497 Css NA 0.1332 mg/L PBTK NA 50% Rat Human -DTXSID3024497 Css NA 0.643 mg/L PBTK NA 95% Rat Human -DTXSID3024499 Clint NA 2.735 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024499 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024499 Vd NA 0.983 L/kg 1compartment NA NA Human Human +DTXSID3024497 TK.Half.Life NA 0.334 hours 1compartment NA NA Rat Human +DTXSID3024497 Css NA 0.001172 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024497 Css NA 0.01226 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024497 Css NA 0.0008728 mg/L PBTK NA 50% Rat Human +DTXSID3024497 Css NA 0.008225 mg/L PBTK NA 95% Rat Human +DTXSID3024499 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024499 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024499 Vd NA 0.6272 L/kg 1compartment NA NA Human Human DTXSID3024499 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024499 TK.Half.Life NA 1.512 hours 1compartment NA NA Human Human -DTXSID3024499 Css NA 0.1502 mg/L 3compartmentss NA 50% Human Human -DTXSID3024499 Css NA 1.181 mg/L 3compartmentss NA 95% Human Human -DTXSID3024499 Css NA 0.1309 mg/L PBTK NA 50% Human Human -DTXSID3024499 Css NA 0.8576 mg/L PBTK NA 95% Human Human -DTXSID3024499 Clint NA 2.735 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024499 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024499 Vd NA 0.9934 L/kg 1compartment NA NA Rat Human +DTXSID3024499 TK.Half.Life NA 8.593 hours 1compartment NA NA Human Human +DTXSID3024499 Css NA 1.297 mg/L 3compartmentss NA 50% Human Human +DTXSID3024499 Css NA 6.127 mg/L 3compartmentss NA 95% Human Human +DTXSID3024499 Css NA 0.9946 mg/L PBTK NA 50% Human Human +DTXSID3024499 Css NA 3.935 mg/L PBTK NA 95% Human Human +DTXSID3024499 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024499 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024499 Vd NA 0.631 L/kg 1compartment NA NA Rat Human DTXSID3024499 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024499 TK.Half.Life NA 0.7954 hours 1compartment NA NA Rat Human -DTXSID3024499 Css NA 0.06396 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024499 Css NA 0.459 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024499 Css NA 0.05572 mg/L PBTK NA 50% Rat Human -DTXSID3024499 Css NA 0.2886 mg/L PBTK NA 95% Rat Human -DTXSID3024522 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024522 Fup NA 0.7909 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024522 Vd NA 1.876 L/kg 1compartment NA NA Human Human -DTXSID3024522 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3024522 TK.Half.Life NA 20.53 hours 1compartment NA NA Human Human -DTXSID3024522 Css NA 1.056 mg/L 3compartmentss NA 50% Human Human -DTXSID3024522 Css NA 6.418 mg/L 3compartmentss NA 95% Human Human -DTXSID3024522 Css NA 0.985 mg/L PBTK NA 50% Human Human -DTXSID3024522 Css NA 4.401 mg/L PBTK NA 95% Human Human -DTXSID3024522 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024522 Fup NA 0.7909 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024522 Vd NA 1.596 L/kg 1compartment NA NA Rat Human +DTXSID3024499 TK.Half.Life NA 2.937 hours 1compartment NA NA Rat Human +DTXSID3024499 Css NA 0.02364 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024499 Css NA 0.1646 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024499 Css NA 0.01752 mg/L PBTK NA 50% Rat Human +DTXSID3024499 Css NA 0.1064 mg/L PBTK NA 95% Rat Human +DTXSID3024522 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024522 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024522 Vd NA 1.246 L/kg 1compartment NA NA Human Human +DTXSID3024522 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3024522 TK.Half.Life NA 1.357 hours 1compartment NA NA Human Human +DTXSID3024522 Css NA 0.04704 mg/L 3compartmentss NA 50% Human Human +DTXSID3024522 Css NA 0.3857 mg/L 3compartmentss NA 95% Human Human +DTXSID3024522 Css NA 0.03757 mg/L PBTK NA 50% Human Human +DTXSID3024522 Css NA 0.2721 mg/L PBTK NA 95% Human Human +DTXSID3024522 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024522 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024522 Vd NA 1.068 L/kg 1compartment NA NA Rat Human DTXSID3024522 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024522 TK.Half.Life NA 4.807 hours 1compartment NA NA Rat Human -DTXSID3024522 Css NA 0.276 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024522 Css NA 1.621 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024522 Css NA 0.2515 mg/L PBTK NA 50% Rat Human -DTXSID3024522 Css NA 1.023 mg/L PBTK NA 95% Rat Human -DTXSID3024528 Clint NA 81.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024528 Fup NA 0.168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024528 Vd NA 2.681 L/kg 1compartment NA NA Human Human -DTXSID3024528 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024528 TK.Half.Life NA 4.188 hours 1compartment NA NA Human Human -DTXSID3024528 Css NA 0.09632 mg/L 3compartmentss NA 50% Human Human -DTXSID3024528 Css NA 0.6296 mg/L 3compartmentss NA 95% Human Human -DTXSID3024528 Css NA 0.0686 mg/L PBTK NA 50% Human Human -DTXSID3024528 Css NA 0.4304 mg/L PBTK NA 95% Human Human -DTXSID3024528 Clint NA 81.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024528 Fup NA 0.168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024528 Vd NA 2.029 L/kg 1compartment NA NA Rat Human -DTXSID3024528 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024528 TK.Half.Life NA 1.155 hours 1compartment NA NA Rat Human -DTXSID3024528 Css NA 0.05332 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024528 Css NA 0.2898 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024528 Css NA 0.03662 mg/L PBTK NA 50% Rat Human -DTXSID3024528 Css NA 0.1899 mg/L PBTK NA 95% Rat Human -DTXSID3024574 Clint NA 2.205 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024574 Fup NA 0.4751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024574 Vd NA 0.9409 L/kg 1compartment NA NA Human Human +DTXSID3024522 TK.Half.Life NA 0.5781 hours 1compartment NA NA Rat Human +DTXSID3024522 Css NA 0.005768 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024522 Css NA 0.03848 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024522 Css NA 0.004628 mg/L PBTK NA 50% Rat Human +DTXSID3024522 Css NA 0.02627 mg/L PBTK NA 95% Rat Human +DTXSID3024574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024574 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024574 Vd NA 0.8551 L/kg 1compartment NA NA Human Human DTXSID3024574 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024574 TK.Half.Life NA 3.227 hours 1compartment NA NA Human Human -DTXSID3024574 Css NA 0.328 mg/L 3compartmentss NA 50% Human Human -DTXSID3024574 Css NA 2.11 mg/L 3compartmentss NA 95% Human Human -DTXSID3024574 Css NA 0.2618 mg/L PBTK NA 50% Human Human -DTXSID3024574 Css NA 1.402 mg/L PBTK NA 95% Human Human -DTXSID3024574 Clint NA 2.205 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024574 Fup NA 0.4751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024574 Vd NA 0.8632 L/kg 1compartment NA NA Rat Human +DTXSID3024574 TK.Half.Life NA 0.952 hours 1compartment NA NA Human Human +DTXSID3024574 Css NA 0.04852 mg/L 3compartmentss NA 50% Human Human +DTXSID3024574 Css NA 0.4006 mg/L 3compartmentss NA 95% Human Human +DTXSID3024574 Css NA 0.03709 mg/L PBTK NA 50% Human Human +DTXSID3024574 Css NA 0.2729 mg/L PBTK NA 95% Human Human +DTXSID3024574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024574 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024574 Vd NA 0.7827 L/kg 1compartment NA NA Rat Human DTXSID3024574 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024574 TK.Half.Life NA 1.547 hours 1compartment NA NA Rat Human -DTXSID3024574 Css NA 0.1477 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024574 Css NA 0.7459 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024574 Css NA 0.1142 mg/L PBTK NA 50% Rat Human -DTXSID3024574 Css NA 0.462 mg/L PBTK NA 95% Rat Human -DTXSID3024603 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024603 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024603 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID3024603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024603 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID3024603 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID3024603 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID3024603 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID3024603 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID3024603 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024603 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024603 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human -DTXSID3024603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024603 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID3024603 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024603 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024603 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID3024603 Css NA 1.296 mg/L PBTK NA 95% Rat Human -DTXSID3024657 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024657 Fup NA 0.8385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024657 Vd NA 1.248 L/kg 1compartment NA NA Human Human -DTXSID3024657 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3024657 TK.Half.Life NA 10.25 hours 1compartment NA NA Human Human -DTXSID3024657 Css NA 0.905 mg/L 3compartmentss NA 50% Human Human -DTXSID3024657 Css NA 5.578 mg/L 3compartmentss NA 95% Human Human -DTXSID3024657 Css NA 0.8248 mg/L PBTK NA 50% Human Human -DTXSID3024657 Css NA 3.709 mg/L PBTK NA 95% Human Human -DTXSID3024657 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024657 Fup NA 0.8385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024657 Vd NA 1.165 L/kg 1compartment NA NA Rat Human +DTXSID3024574 TK.Half.Life NA 0.446 hours 1compartment NA NA Rat Human +DTXSID3024574 Css NA 0.005993 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024574 Css NA 0.03615 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024574 Css NA 0.004591 mg/L PBTK NA 50% Rat Human +DTXSID3024574 Css NA 0.02454 mg/L PBTK NA 95% Rat Human +DTXSID3024657 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024657 Fup 0.68 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024657 Vd NA 1.107 L/kg 1compartment NA NA Human Human +DTXSID3024657 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3024657 TK.Half.Life NA 0.9153 hours 1compartment NA NA Human Human +DTXSID3024657 Css NA 0.02296 mg/L 3compartmentss NA 50% Human Human +DTXSID3024657 Css NA 0.2771 mg/L 3compartmentss NA 95% Human Human +DTXSID3024657 Css NA 0.0196 mg/L PBTK NA 50% Human Human +DTXSID3024657 Css NA 0.1998 mg/L PBTK NA 95% Human Human +DTXSID3024657 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024657 Fup 0.68 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024657 Vd NA 1.03 L/kg 1compartment NA NA Rat Human DTXSID3024657 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024657 TK.Half.Life NA 3.111 hours 1compartment NA NA Rat Human -DTXSID3024657 Css NA 0.2303 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024657 Css NA 1.436 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024657 Css NA 0.2038 mg/L PBTK NA 50% Rat Human -DTXSID3024657 Css NA 0.8889 mg/L PBTK NA 95% Rat Human -DTXSID3024736 Clint NA 5.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024736 Fup NA 0.3638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024736 Vd NA 2.792 L/kg 1compartment NA NA Human Human -DTXSID3024736 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3024736 TK.Half.Life NA 20.04 hours 1compartment NA NA Human Human -DTXSID3024736 Css NA 0.7635 mg/L 3compartmentss NA 50% Human Human -DTXSID3024736 Css NA 3.789 mg/L 3compartmentss NA 95% Human Human -DTXSID3024736 Css NA 0.572 mg/L PBTK NA 50% Human Human -DTXSID3024736 Css NA 2.667 mg/L PBTK NA 95% Human Human -DTXSID3024736 Clint NA 5.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024736 Fup NA 0.3638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024736 Vd NA 2.135 L/kg 1compartment NA NA Rat Human +DTXSID3024657 TK.Half.Life NA 0.4158 hours 1compartment NA NA Rat Human +DTXSID3024657 Css NA 0.0008053 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024657 Css NA 0.01122 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024657 Css NA 0.0006801 mg/L PBTK NA 50% Rat Human +DTXSID3024657 Css NA 0.007609 mg/L PBTK NA 95% Rat Human +DTXSID3024736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024736 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024736 Vd NA 2.477 L/kg 1compartment NA NA Human Human +DTXSID3024736 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3024736 TK.Half.Life NA 6.736 hours 1compartment NA NA Human Human +DTXSID3024736 Css NA 0.23 mg/L 3compartmentss NA 50% Human Human +DTXSID3024736 Css NA 1.498 mg/L 3compartmentss NA 95% Human Human +DTXSID3024736 Css NA 0.166 mg/L PBTK NA 50% Human Human +DTXSID3024736 Css NA 1.033 mg/L PBTK NA 95% Human Human +DTXSID3024736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024736 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024736 Vd NA 1.886 L/kg 1compartment NA NA Rat Human DTXSID3024736 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024736 TK.Half.Life NA 4.178 hours 1compartment NA NA Rat Human -DTXSID3024736 Css NA 0.3889 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024736 Css NA 1.393 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024736 Css NA 0.2822 mg/L PBTK NA 50% Rat Human -DTXSID3024736 Css NA 0.9562 mg/L PBTK NA 95% Rat Human -DTXSID3024786 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024786 Fup NA 0.3159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024786 Vd NA 0.3065 L/kg 1compartment NA NA Human Human +DTXSID3024736 TK.Half.Life NA 1.88 hours 1compartment NA NA Rat Human +DTXSID3024736 Css NA 0.02953 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024736 Css NA 0.1441 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024736 Css NA 0.02116 mg/L PBTK NA 50% Rat Human +DTXSID3024736 Css NA 0.09911 mg/L PBTK NA 95% Rat Human +DTXSID3024738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024738 Fup 0.0813 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024738 Vd NA 2.858 L/kg 1compartment NA NA Human Human +DTXSID3024738 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3024738 TK.Half.Life NA 22.35 hours 1compartment NA NA Human Human +DTXSID3024738 Css NA 0.8984 mg/L 3compartmentss NA 50% Human Human +DTXSID3024738 Css NA 6.07 mg/L 3compartmentss NA 95% Human Human +DTXSID3024738 Css NA 0.622 mg/L PBTK NA 50% Human Human +DTXSID3024738 Css NA 4.05 mg/L PBTK NA 95% Human Human +DTXSID3024738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024738 Fup 0.0813 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024738 Vd NA 2.146 L/kg 1compartment NA NA Rat Human +DTXSID3024738 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3024738 TK.Half.Life NA 4.381 hours 1compartment NA NA Rat Human +DTXSID3024738 Css NA 0.1172 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024738 Css NA 0.617 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024738 Css NA 0.0803 mg/L PBTK NA 50% Rat Human +DTXSID3024738 Css NA 0.4023 mg/L PBTK NA 95% Rat Human +DTXSID3024786 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024786 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024786 Vd NA 0.3585 L/kg 1compartment NA NA Human Human DTXSID3024786 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024786 TK.Half.Life NA 6.279 hours 1compartment NA NA Human Human -DTXSID3024786 Css NA 2.54 mg/L 3compartmentss NA 50% Human Human -DTXSID3024786 Css NA 10.16 mg/L 3compartmentss NA 95% Human Human -DTXSID3024786 Css NA 1.664 mg/L PBTK NA 50% Human Human -DTXSID3024786 Css NA 6.097 mg/L PBTK NA 95% Human Human -DTXSID3024786 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024786 Fup NA 0.3159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024786 Vd NA 0.3146 L/kg 1compartment NA NA Rat Human +DTXSID3024786 TK.Half.Life NA 6.059 hours 1compartment NA NA Human Human +DTXSID3024786 Css NA 1.091 mg/L 3compartmentss NA 50% Human Human +DTXSID3024786 Css NA 4.784 mg/L 3compartmentss NA 95% Human Human +DTXSID3024786 Css NA 0.7465 mg/L PBTK NA 50% Human Human +DTXSID3024786 Css NA 2.977 mg/L PBTK NA 95% Human Human +DTXSID3024786 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024786 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024786 Vd NA 0.3652 L/kg 1compartment NA NA Rat Human DTXSID3024786 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024786 TK.Half.Life NA 2.196 hours 1compartment NA NA Rat Human -DTXSID3024786 Css NA 0.7166 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024786 Css NA 2.301 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024786 Css NA 0.4435 mg/L PBTK NA 50% Rat Human -DTXSID3024786 Css NA 1.304 mg/L PBTK NA 95% Rat Human -DTXSID3024815 Clint NA 6.044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024815 Fup NA 0.2986 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024815 Vd NA 1.453 L/kg 1compartment NA NA Human Human +DTXSID3024786 TK.Half.Life NA 2.102 hours 1compartment NA NA Rat Human +DTXSID3024786 Css NA 0.005951 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024786 Css NA 0.02588 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024786 Css NA 0.003868 mg/L PBTK NA 50% Rat Human +DTXSID3024786 Css NA 0.01527 mg/L PBTK NA 95% Rat Human +DTXSID3024815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024815 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024815 Vd NA 0.8528 L/kg 1compartment NA NA Human Human DTXSID3024815 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024815 TK.Half.Life NA 4.239 hours 1compartment NA NA Human Human -DTXSID3024815 Css NA 0.2692 mg/L 3compartmentss NA 50% Human Human -DTXSID3024815 Css NA 1.586 mg/L 3compartmentss NA 95% Human Human -DTXSID3024815 Css NA 0.2036 mg/L PBTK NA 50% Human Human -DTXSID3024815 Css NA 1.105 mg/L PBTK NA 95% Human Human -DTXSID3024815 Clint NA 6.044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024815 Fup NA 0.2986 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024815 Vd NA 1.18 L/kg 1compartment NA NA Rat Human +DTXSID3024815 TK.Half.Life NA 2.794 hours 1compartment NA NA Human Human +DTXSID3024815 Css NA 0.3954 mg/L 3compartmentss NA 50% Human Human +DTXSID3024815 Css NA 3.078 mg/L 3compartmentss NA 95% Human Human +DTXSID3024815 Css NA 0.2494 mg/L PBTK NA 50% Human Human +DTXSID3024815 Css NA 1.863 mg/L PBTK NA 95% Human Human +DTXSID3024815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024815 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024815 Vd NA 0.6696 L/kg 1compartment NA NA Rat Human DTXSID3024815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024815 TK.Half.Life NA 1.742 hours 1compartment NA NA Rat Human -DTXSID3024815 Css NA 0.1377 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024815 Css NA 0.5906 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024815 Css NA 0.1009 mg/L PBTK NA 50% Rat Human -DTXSID3024815 Css NA 0.3784 mg/L PBTK NA 95% Rat Human -DTXSID3024861 Clint NA 112.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024861 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024861 Vd NA 2.473 L/kg 1compartment NA NA Human Human -DTXSID3024861 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024861 TK.Half.Life NA 11.02 hours 1compartment NA NA Human Human -DTXSID3024861 Css NA 0.5548 mg/L 3compartmentss NA 50% Human Human -DTXSID3024861 Css NA 4.111 mg/L 3compartmentss NA 95% Human Human -DTXSID3024861 Css NA 0.3642 mg/L PBTK NA 50% Human Human -DTXSID3024861 Css NA 2.612 mg/L PBTK NA 95% Human Human -DTXSID3024861 Clint NA 112.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024861 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024861 Vd NA 1.84 L/kg 1compartment NA NA Rat Human -DTXSID3024861 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024861 TK.Half.Life NA 2.887 hours 1compartment NA NA Rat Human -DTXSID3024861 Css NA 0.3168 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024861 Css NA 1.995 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024861 Css NA 0.196 mg/L PBTK NA 50% Rat Human -DTXSID3024861 Css NA 1.192 mg/L PBTK NA 95% Rat Human -DTXSID3024869 Clint NA 0.02065 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024869 Fup NA 0.3359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024869 Vd NA 2.005 L/kg 1compartment NA NA Human Human -DTXSID3024869 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID3024869 TK.Half.Life NA 62.28 hours 1compartment NA NA Human Human -DTXSID3024869 Css NA 3.262 mg/L 3compartmentss NA 50% Human Human -DTXSID3024869 Css NA 11.33 mg/L 3compartmentss NA 95% Human Human -DTXSID3024869 Css NA 2.542 mg/L PBTK NA 50% Human Human -DTXSID3024869 Css NA 7.727 mg/L PBTK NA 95% Human Human -DTXSID3024869 Clint NA 0.02065 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024869 Fup NA 0.3359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024869 Vd NA 1.581 L/kg 1compartment NA NA Rat Human -DTXSID3024869 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3024869 TK.Half.Life NA 11.83 hours 1compartment NA NA Rat Human -DTXSID3024869 Css NA 0.9108 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024869 Css NA 2.669 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024869 Css NA 0.6829 mg/L PBTK NA 50% Rat Human -DTXSID3024869 Css NA 1.67 mg/L PBTK NA 95% Rat Human -DTXSID3024940 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024940 Fup NA 0.8672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024940 Vd NA 2.261 L/kg 1compartment NA NA Human Human -DTXSID3024940 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3024940 TK.Half.Life NA 28.05 hours 1compartment NA NA Human Human -DTXSID3024940 Css NA 1.168 mg/L 3compartmentss NA 50% Human Human -DTXSID3024940 Css NA 6.024 mg/L 3compartmentss NA 95% Human Human -DTXSID3024940 Css NA 1.1 mg/L PBTK NA 50% Human Human -DTXSID3024940 Css NA 4.321 mg/L PBTK NA 95% Human Human -DTXSID3024940 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024940 Fup NA 0.8672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024940 Vd NA 1.871 L/kg 1compartment NA NA Rat Human -DTXSID3024940 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024940 TK.Half.Life NA 5.51 hours 1compartment NA NA Rat Human -DTXSID3024940 Css NA 0.308 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024940 Css NA 1.544 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024940 Css NA 0.2832 mg/L PBTK NA 50% Rat Human -DTXSID3024940 Css NA 0.9995 mg/L PBTK NA 95% Rat Human -DTXSID3024942 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024942 Fup NA 0.8211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024942 Vd NA 0.9507 L/kg 1compartment NA NA Human Human +DTXSID3024815 TK.Half.Life NA 1.269 hours 1compartment NA NA Rat Human +DTXSID3024815 Css NA 0.05239 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024815 Css NA 0.3137 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024815 Css NA 0.03205 mg/L PBTK NA 50% Rat Human +DTXSID3024815 Css NA 0.186 mg/L PBTK NA 95% Rat Human +DTXSID3024869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024869 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024869 Vd NA 1.346 L/kg 1compartment NA NA Human Human +DTXSID3024869 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3024869 TK.Half.Life NA 1.652 hours 1compartment NA NA Human Human +DTXSID3024869 Css NA 0.06012 mg/L 3compartmentss NA 50% Human Human +DTXSID3024869 Css NA 0.4573 mg/L 3compartmentss NA 95% Human Human +DTXSID3024869 Css NA 0.04676 mg/L PBTK NA 50% Human Human +DTXSID3024869 Css NA 0.324 mg/L PBTK NA 95% Human Human +DTXSID3024869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024869 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024869 Vd NA 1.119 L/kg 1compartment NA NA Rat Human +DTXSID3024869 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3024869 TK.Half.Life NA 0.6822 hours 1compartment NA NA Rat Human +DTXSID3024869 Css NA 0.007532 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024869 Css NA 0.04614 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024869 Css NA 0.005833 mg/L PBTK NA 50% Rat Human +DTXSID3024869 Css NA 0.03132 mg/L PBTK NA 95% Rat Human +DTXSID3024942 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024942 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024942 Vd NA 0.521 L/kg 1compartment NA NA Human Human DTXSID3024942 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024942 TK.Half.Life NA 7.727 hours 1compartment NA NA Human Human -DTXSID3024942 Css NA 0.9663 mg/L 3compartmentss NA 50% Human Human -DTXSID3024942 Css NA 5.949 mg/L 3compartmentss NA 95% Human Human -DTXSID3024942 Css NA 0.8143 mg/L PBTK NA 50% Human Human -DTXSID3024942 Css NA 3.892 mg/L PBTK NA 95% Human Human -DTXSID3024942 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024942 Fup NA 0.8211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024942 Vd NA 0.9049 L/kg 1compartment NA NA Rat Human +DTXSID3024942 TK.Half.Life NA 0.5672 hours 1compartment NA NA Human Human +DTXSID3024942 Css NA 0.04608 mg/L 3compartmentss NA 50% Human Human +DTXSID3024942 Css NA 0.3676 mg/L 3compartmentss NA 95% Human Human +DTXSID3024942 Css NA 0.03331 mg/L PBTK NA 50% Human Human +DTXSID3024942 Css NA 0.2447 mg/L PBTK NA 95% Human Human +DTXSID3024942 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024942 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024942 Vd NA 0.5206 L/kg 1compartment NA NA Rat Human DTXSID3024942 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024942 TK.Half.Life NA 2.448 hours 1compartment NA NA Rat Human -DTXSID3024942 Css NA 0.2476 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024942 Css NA 1.513 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024942 Css NA 0.203 mg/L PBTK NA 50% Rat Human -DTXSID3024942 Css NA 0.9116 mg/L PBTK NA 95% Rat Human -DTXSID3024944 Clint NA 2.283 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024944 Fup NA 0.5685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024944 Vd NA 1.732 L/kg 1compartment NA NA Human Human +DTXSID3024942 TK.Half.Life NA 0.287 hours 1compartment NA NA Rat Human +DTXSID3024942 Css NA 0.005588 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024942 Css NA 0.03595 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024942 Css NA 0.004037 mg/L PBTK NA 50% Rat Human +DTXSID3024942 Css NA 0.02327 mg/L PBTK NA 95% Rat Human +DTXSID3024944 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024944 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3024944 Vd NA 1.294 L/kg 1compartment NA NA Human Human DTXSID3024944 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024944 TK.Half.Life NA 5.874 hours 1compartment NA NA Human Human -DTXSID3024944 Css NA 0.3196 mg/L 3compartmentss NA 50% Human Human -DTXSID3024944 Css NA 2.22 mg/L 3compartmentss NA 95% Human Human -DTXSID3024944 Css NA 0.2747 mg/L PBTK NA 50% Human Human -DTXSID3024944 Css NA 1.524 mg/L PBTK NA 95% Human Human -DTXSID3024944 Clint NA 2.283 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024944 Fup NA 0.5685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024944 Vd NA 1.446 L/kg 1compartment NA NA Rat Human +DTXSID3024944 TK.Half.Life NA 2.155 hours 1compartment NA NA Human Human +DTXSID3024944 Css NA 0.1099 mg/L 3compartmentss NA 50% Human Human +DTXSID3024944 Css NA 0.7478 mg/L 3compartmentss NA 95% Human Human +DTXSID3024944 Css NA 0.07866 mg/L PBTK NA 50% Human Human +DTXSID3024944 Css NA 0.5075 mg/L PBTK NA 95% Human Human +DTXSID3024944 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024944 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3024944 Vd NA 1.039 L/kg 1compartment NA NA Rat Human DTXSID3024944 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024944 TK.Half.Life NA 2.215 hours 1compartment NA NA Rat Human -DTXSID3024944 Css NA 0.1431 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024944 Css NA 0.8969 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024944 Css NA 0.1203 mg/L PBTK NA 50% Rat Human -DTXSID3024944 Css NA 0.5557 mg/L PBTK NA 95% Rat Human +DTXSID3024944 TK.Half.Life NA 0.8862 hours 1compartment NA NA Rat Human +DTXSID3024944 Css NA 0.01372 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024944 Css NA 0.07269 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024944 Css NA 0.009744 mg/L PBTK NA 50% Rat Human +DTXSID3024944 Css NA 0.04873 mg/L PBTK NA 95% Rat Human DTXSID3024994 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3024994 Fup NA 0.4187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3024994 Vd NA 0.376 L/kg 1compartment NA NA Human Human +DTXSID3024994 Vd NA 0.3578 L/kg 1compartment NA NA Human Human DTXSID3024994 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3024994 TK.Half.Life NA 5.81 hours 1compartment NA NA Human Human -DTXSID3024994 Css NA 1.862 mg/L 3compartmentss NA 50% Human Human -DTXSID3024994 Css NA 7.836 mg/L 3compartmentss NA 95% Human Human -DTXSID3024994 Css NA 1.29 mg/L PBTK NA 50% Human Human -DTXSID3024994 Css NA 4.843 mg/L PBTK NA 95% Human Human +DTXSID3024994 TK.Half.Life NA 5.527 hours 1compartment NA NA Human Human +DTXSID3024994 Css NA 1.818 mg/L 3compartmentss NA 50% Human Human +DTXSID3024994 Css NA 7.617 mg/L 3compartmentss NA 95% Human Human +DTXSID3024994 Css NA 1.247 mg/L PBTK NA 50% Human Human +DTXSID3024994 Css NA 4.693 mg/L PBTK NA 95% Human Human DTXSID3024994 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3024994 Fup NA 0.4187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3024994 Vd NA 0.3832 L/kg 1compartment NA NA Rat Human +DTXSID3024994 Vd NA 0.367 L/kg 1compartment NA NA Rat Human DTXSID3024994 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3024994 TK.Half.Life NA 2.018 hours 1compartment NA NA Rat Human -DTXSID3024994 Css NA 0.5097 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024994 Css NA 1.882 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024994 Css NA 0.3338 mg/L PBTK NA 50% Rat Human -DTXSID3024994 Css NA 1.083 mg/L PBTK NA 95% Rat Human +DTXSID3024994 TK.Half.Life NA 1.933 hours 1compartment NA NA Rat Human +DTXSID3024994 Css NA 0.1164 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024994 Css NA 0.4251 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024994 Css NA 0.07817 mg/L PBTK NA 50% Rat Human +DTXSID3024994 Css NA 0.2526 mg/L PBTK NA 95% Rat Human DTXSID3024998 Clint NA 1.764 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3024998 Fup NA 0.1059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3024998 Vd NA 2.037 L/kg 1compartment NA NA Human Human DTXSID3024998 Days.Css NA 7 Days PBTK NA NA Human Human DTXSID3024998 TK.Half.Life NA 50.56 hours 1compartment NA NA Human Human -DTXSID3024998 Css NA 3.494 mg/L 3compartmentss NA 50% Human Human -DTXSID3024998 Css NA 16.01 mg/L 3compartmentss NA 95% Human Human -DTXSID3024998 Css NA 2.371 mg/L PBTK NA 50% Human Human -DTXSID3024998 Css NA 10.11 mg/L PBTK NA 95% Human Human +DTXSID3024998 Css NA 3.394 mg/L 3compartmentss NA 50% Human Human +DTXSID3024998 Css NA 15.64 mg/L 3compartmentss NA 95% Human Human +DTXSID3024998 Css NA 2.31 mg/L PBTK NA 50% Human Human +DTXSID3024998 Css NA 9.809 mg/L PBTK NA 95% Human Human DTXSID3024998 Clint NA 1.764 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3024998 Fup NA 0.1059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3024998 Vd NA 1.544 L/kg 1compartment NA NA Rat Human DTXSID3024998 Days.Css NA 3 Days PBTK NA NA Rat Human DTXSID3024998 TK.Half.Life NA 13.99 hours 1compartment NA NA Rat Human -DTXSID3024998 Css NA 1.604 mg/L 3compartmentss NA 50% Rat Human -DTXSID3024998 Css NA 5.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID3024998 Css NA 1.034 mg/L PBTK NA 50% Rat Human -DTXSID3024998 Css NA 3.269 mg/L PBTK NA 95% Rat Human -DTXSID3025045 Clint NA 2.011 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025045 Fup NA 0.6289 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025045 Vd NA 0.8572 L/kg 1compartment NA NA Human Human +DTXSID3024998 Css NA 0.358 mg/L 3compartmentss NA 50% Rat Human +DTXSID3024998 Css NA 1.304 mg/L 3compartmentss NA 95% Rat Human +DTXSID3024998 Css NA 0.2404 mg/L PBTK NA 50% Rat Human +DTXSID3024998 Css NA 0.7871 mg/L PBTK NA 95% Rat Human +DTXSID3025045 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025045 Fup 0.519 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025045 Vd NA 0.948 L/kg 1compartment NA NA Human Human DTXSID3025045 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025045 TK.Half.Life NA 2.381 hours 1compartment NA NA Human Human -DTXSID3025045 Css NA 0.2786 mg/L 3compartmentss NA 50% Human Human -DTXSID3025045 Css NA 2.151 mg/L 3compartmentss NA 95% Human Human -DTXSID3025045 Css NA 0.23 mg/L PBTK NA 50% Human Human -DTXSID3025045 Css NA 1.385 mg/L PBTK NA 95% Human Human -DTXSID3025045 Clint NA 2.011 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025045 Fup NA 0.6289 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025045 Vd NA 0.8344 L/kg 1compartment NA NA Rat Human +DTXSID3025045 TK.Half.Life NA 0.9124 hours 1compartment NA NA Human Human +DTXSID3025045 Css NA 0.03664 mg/L 3compartmentss NA 50% Human Human +DTXSID3025045 Css NA 0.35 mg/L 3compartmentss NA 95% Human Human +DTXSID3025045 Css NA 0.02948 mg/L PBTK NA 50% Human Human +DTXSID3025045 Css NA 0.2461 mg/L PBTK NA 95% Human Human +DTXSID3025045 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025045 Fup 0.519 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025045 Vd NA 0.8795 L/kg 1compartment NA NA Rat Human DTXSID3025045 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025045 TK.Half.Life NA 1.206 hours 1compartment NA NA Rat Human -DTXSID3025045 Css NA 0.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025045 Css NA 0.8477 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025045 Css NA 0.09584 mg/L PBTK NA 50% Rat Human -DTXSID3025045 Css NA 0.5097 mg/L PBTK NA 95% Rat Human -DTXSID3025047 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025047 Fup NA 0.7083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025047 Vd NA 0.8592 L/kg 1compartment NA NA Human Human +DTXSID3025045 TK.Half.Life NA 0.4232 hours 1compartment NA NA Rat Human +DTXSID3025045 Css NA 0.004459 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025045 Css NA 0.03603 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025045 Css NA 0.003646 mg/L PBTK NA 50% Rat Human +DTXSID3025045 Css NA 0.02423 mg/L PBTK NA 95% Rat Human +DTXSID3025047 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025047 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025047 Vd NA 0.7155 L/kg 1compartment NA NA Human Human DTXSID3025047 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025047 TK.Half.Life NA 7.948 hours 1compartment NA NA Human Human -DTXSID3025047 Css NA 1.058 mg/L 3compartmentss NA 50% Human Human -DTXSID3025047 Css NA 6.944 mg/L 3compartmentss NA 95% Human Human -DTXSID3025047 Css NA 0.8836 mg/L PBTK NA 50% Human Human -DTXSID3025047 Css NA 4.487 mg/L PBTK NA 95% Human Human -DTXSID3025047 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025047 Fup NA 0.7083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025047 Vd NA 0.8493 L/kg 1compartment NA NA Rat Human +DTXSID3025047 TK.Half.Life NA 8.967 hours 1compartment NA NA Human Human +DTXSID3025047 Css NA 1.346 mg/L 3compartmentss NA 50% Human Human +DTXSID3025047 Css NA 7.659 mg/L 3compartmentss NA 95% Human Human +DTXSID3025047 Css NA 1.062 mg/L PBTK NA 50% Human Human +DTXSID3025047 Css NA 4.893 mg/L PBTK NA 95% Human Human +DTXSID3025047 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025047 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025047 Vd NA 0.7059 L/kg 1compartment NA NA Rat Human DTXSID3025047 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025047 TK.Half.Life NA 2.652 hours 1compartment NA NA Rat Human -DTXSID3025047 Css NA 0.2709 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025047 Css NA 1.755 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025047 Css NA 0.2204 mg/L PBTK NA 50% Rat Human -DTXSID3025047 Css NA 1.049 mg/L PBTK NA 95% Rat Human -DTXSID3025049 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025049 Fup NA 0.9728 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025049 Vd NA 0.8287 L/kg 1compartment NA NA Human Human +DTXSID3025047 TK.Half.Life NA 2.994 hours 1compartment NA NA Rat Human +DTXSID3025047 Css NA 0.0832 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025047 Css NA 0.4305 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025047 Css NA 0.06517 mg/L PBTK NA 50% Rat Human +DTXSID3025047 Css NA 0.2646 mg/L PBTK NA 95% Rat Human +DTXSID3025049 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025049 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025049 Vd NA 0.705 L/kg 1compartment NA NA Human Human DTXSID3025049 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025049 TK.Half.Life NA 5.523 hours 1compartment NA NA Human Human -DTXSID3025049 Css NA 0.8692 mg/L 3compartmentss NA 50% Human Human -DTXSID3025049 Css NA 4.976 mg/L 3compartmentss NA 95% Human Human -DTXSID3025049 Css NA 0.738 mg/L PBTK NA 50% Human Human -DTXSID3025049 Css NA 3.284 mg/L PBTK NA 95% Human Human -DTXSID3025049 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025049 Fup NA 0.9728 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025049 Vd NA 0.8556 L/kg 1compartment NA NA Rat Human +DTXSID3025049 TK.Half.Life NA 5.825 hours 1compartment NA NA Human Human +DTXSID3025049 Css NA 0.855 mg/L 3compartmentss NA 50% Human Human +DTXSID3025049 Css NA 5.454 mg/L 3compartmentss NA 95% Human Human +DTXSID3025049 Css NA 0.7002 mg/L PBTK NA 50% Human Human +DTXSID3025049 Css NA 3.473 mg/L PBTK NA 95% Human Human +DTXSID3025049 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025049 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025049 Vd NA 0.7317 L/kg 1compartment NA NA Rat Human DTXSID3025049 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025049 TK.Half.Life NA 1.94 hours 1compartment NA NA Rat Human -DTXSID3025049 Css NA 0.2199 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025049 Css NA 1.243 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025049 Css NA 0.1818 mg/L PBTK NA 50% Rat Human -DTXSID3025049 Css NA 0.7569 mg/L PBTK NA 95% Rat Human +DTXSID3025049 TK.Half.Life NA 2.058 hours 1compartment NA NA Rat Human +DTXSID3025049 Css NA 0.01606 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025049 Css NA 0.1291 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025049 Css NA 0.0126 mg/L PBTK NA 50% Rat Human +DTXSID3025049 Css NA 0.08235 mg/L PBTK NA 95% Rat Human DTXSID3025091 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3025091 Fup 0.3343 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3025091 Vd NA 1.289 L/kg 1compartment NA NA Human Human DTXSID3025091 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID3025091 TK.Half.Life NA 28.76 hours 1compartment NA NA Human Human -DTXSID3025091 Css NA 2.404 mg/L 3compartmentss NA 50% Human Human -DTXSID3025091 Css NA 9.434 mg/L 3compartmentss NA 95% Human Human -DTXSID3025091 Css NA 1.861 mg/L PBTK NA 50% Human Human -DTXSID3025091 Css NA 6.155 mg/L PBTK NA 95% Human Human +DTXSID3025091 Css NA 2.299 mg/L 3compartmentss NA 50% Human Human +DTXSID3025091 Css NA 9.275 mg/L 3compartmentss NA 95% Human Human +DTXSID3025091 Css NA 1.786 mg/L PBTK NA 50% Human Human +DTXSID3025091 Css NA 6.136 mg/L PBTK NA 95% Human Human DTXSID3025091 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3025091 Fup 0.3343 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3025091 Vd NA 1.095 L/kg 1compartment NA NA Rat Human DTXSID3025091 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3025091 TK.Half.Life NA 7.485 hours 1compartment NA NA Rat Human -DTXSID3025091 Css NA 0.6514 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025091 Css NA 2.208 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025091 Css NA 0.4844 mg/L PBTK NA 50% Rat Human -DTXSID3025091 Css NA 1.353 mg/L PBTK NA 95% Rat Human -DTXSID3025093 Clint NA 323.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025093 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025093 Vd NA 1.126 L/kg 1compartment NA NA Human Human +DTXSID3025091 Css NA 0.1473 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025091 Css NA 0.5006 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025091 Css NA 0.1135 mg/L PBTK NA 50% Rat Human +DTXSID3025091 Css NA 0.3178 mg/L PBTK NA 95% Rat Human +DTXSID3025093 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025093 Fup 0.0734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025093 Vd NA 1.957 L/kg 1compartment NA NA Human Human DTXSID3025093 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025093 TK.Half.Life NA 1.248 hours 1compartment NA NA Human Human -DTXSID3025093 Css NA 0.03766 mg/L 3compartmentss NA 50% Human Human -DTXSID3025093 Css NA 0.3366 mg/L 3compartmentss NA 95% Human Human -DTXSID3025093 Css NA 0.02399 mg/L PBTK NA 50% Human Human -DTXSID3025093 Css NA 0.2058 mg/L PBTK NA 95% Human Human -DTXSID3025093 Clint NA 323.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025093 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025093 Vd NA 0.8572 L/kg 1compartment NA NA Rat Human +DTXSID3025093 TK.Half.Life NA 7.946 hours 1compartment NA NA Human Human +DTXSID3025093 Css NA 0.4728 mg/L 3compartmentss NA 50% Human Human +DTXSID3025093 Css NA 3.515 mg/L 3compartmentss NA 95% Human Human +DTXSID3025093 Css NA 0.3147 mg/L PBTK NA 50% Human Human +DTXSID3025093 Css NA 2.21 mg/L PBTK NA 95% Human Human +DTXSID3025093 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025093 Fup 0.0734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025093 Vd NA 1.475 L/kg 1compartment NA NA Rat Human DTXSID3025093 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025093 TK.Half.Life NA 0.4466 hours 1compartment NA NA Rat Human -DTXSID3025093 Css NA 0.02186 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025093 Css NA 0.1469 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025093 Css NA 0.01296 mg/L PBTK NA 50% Rat Human -DTXSID3025093 Css NA 0.08512 mg/L PBTK NA 95% Rat Human +DTXSID3025093 TK.Half.Life NA 2.658 hours 1compartment NA NA Rat Human +DTXSID3025093 Css NA 0.06228 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025093 Css NA 0.3517 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025093 Css NA 0.04057 mg/L PBTK NA 50% Rat Human +DTXSID3025093 Css NA 0.2197 mg/L PBTK NA 95% Rat Human DTXSID3025122 Clint 46.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3025122 Fup 0.6989 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3025122 Vd NA 0.9284 L/kg 1compartment NA NA Human Human DTXSID3025122 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3025122 TK.Half.Life NA 0.6539 hours 1compartment NA NA Human Human -DTXSID3025122 Css NA 0.0149 mg/L 3compartmentss NA 50% Human Human -DTXSID3025122 Css NA 0.1655 mg/L 3compartmentss NA 95% Human Human -DTXSID3025122 Css NA 0.0124 mg/L PBTK NA 50% Human Human -DTXSID3025122 Css NA 0.116 mg/L PBTK NA 95% Human Human +DTXSID3025122 Css NA 0.01266 mg/L 3compartmentss NA 50% Human Human +DTXSID3025122 Css NA 0.1644 mg/L 3compartmentss NA 95% Human Human +DTXSID3025122 Css NA 0.01053 mg/L PBTK NA 50% Human Human +DTXSID3025122 Css NA 0.1196 mg/L PBTK NA 95% Human Human DTXSID3025122 Clint 46.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3025122 Fup 0.6989 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3025122 Vd NA 0.9015 L/kg 1compartment NA NA Rat Human DTXSID3025122 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3025122 TK.Half.Life NA 0.2947 hours 1compartment NA NA Rat Human -DTXSID3025122 Css NA 0.00761 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025122 Css NA 0.07305 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025122 Css NA 0.006272 mg/L PBTK NA 50% Rat Human -DTXSID3025122 Css NA 0.04949 mg/L PBTK NA 95% Rat Human -DTXSID3025170 Clint NA 17.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025170 Fup NA 0.0081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025170 Vd NA 2066 L/kg 1compartment NA NA Human Human -DTXSID3025170 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID3025170 TK.Half.Life NA 77870 hours 1compartment NA NA Human Human -DTXSID3025170 Css NA 0.008867 mg/L 3compartmentss NA 50% Human Human -DTXSID3025170 Css NA 0.05598 mg/L 3compartmentss NA 95% Human Human -DTXSID3025170 Css NA 3.121 mg/L PBTK NA 50% Human Human -DTXSID3025170 Css NA 17.38 mg/L PBTK NA 95% Human Human -DTXSID3025170 Clint NA 17.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025170 Fup NA 0.0081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025170 Vd NA 1913 L/kg 1compartment NA NA Rat Human -DTXSID3025170 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID3025170 TK.Half.Life NA 12690 hours 1compartment NA NA Rat Human -DTXSID3025170 Css NA 0.004559 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025170 Css NA 0.01956 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025170 Css NA 1.708 mg/L PBTK NA 50% Rat Human -DTXSID3025170 Css NA 7.116 mg/L PBTK NA 95% Rat Human +DTXSID3025122 Css NA 0.001544 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025122 Css NA 0.01665 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025122 Css NA 0.001318 mg/L PBTK NA 50% Rat Human +DTXSID3025122 Css NA 0.01163 mg/L PBTK NA 95% Rat Human DTXSID3025178 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3025178 Fup 0.7844 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3025178 Vd NA 6.811 L/kg 1compartment NA NA Human Human -DTXSID3025178 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID3025178 TK.Half.Life NA 57.52 hours 1compartment NA NA Human Human -DTXSID3025178 Css NA 0.4074 mg/L 3compartmentss NA 50% Human Human -DTXSID3025178 Css NA 4.218 mg/L 3compartmentss NA 95% Human Human -DTXSID3025178 Css NA 0.8277 mg/L PBTK NA 50% Human Human -DTXSID3025178 Css NA 3.966 mg/L PBTK NA 95% Human Human +DTXSID3025178 Vd NA 4.422 L/kg 1compartment NA NA Human Human +DTXSID3025178 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3025178 TK.Half.Life NA 36.58 hours 1compartment NA NA Human Human +DTXSID3025178 Css NA 0.5346 mg/L 3compartmentss NA 50% Human Human +DTXSID3025178 Css NA 4.757 mg/L 3compartmentss NA 95% Human Human +DTXSID3025178 Css NA 0.8016 mg/L PBTK NA 50% Human Human +DTXSID3025178 Css NA 3.826 mg/L PBTK NA 95% Human Human DTXSID3025178 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3025178 Fup 0.7844 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3025178 Vd NA 6.934 L/kg 1compartment NA NA Rat Human -DTXSID3025178 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3025178 TK.Half.Life NA 19.6 hours 1compartment NA NA Rat Human -DTXSID3025178 Css NA 0.09861 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025178 Css NA 1.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025178 Css NA 0.2083 mg/L PBTK NA 50% Rat Human -DTXSID3025178 Css NA 0.9414 mg/L PBTK NA 95% Rat Human +DTXSID3025178 Vd NA 4.472 L/kg 1compartment NA NA Rat Human +DTXSID3025178 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3025178 TK.Half.Life NA 12.58 hours 1compartment NA NA Rat Human +DTXSID3025178 Css NA 0.02974 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025178 Css NA 0.262 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025178 Css NA 0.04735 mg/L PBTK NA 50% Rat Human +DTXSID3025178 Css NA 0.2078 mg/L PBTK NA 95% Rat Human DTXSID3025203 Clint NA 6.303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3025203 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025203 Vd NA 0.2037 L/kg 1compartment NA NA Human Human -DTXSID3025203 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3025203 TK.Half.Life NA 18.91 hours 1compartment NA NA Human Human -DTXSID3025203 Css NA 17.41 mg/L 3compartmentss NA 50% Human Human -DTXSID3025203 Css NA 152.3 mg/L 3compartmentss NA 95% Human Human -DTXSID3025203 Css NA 10.18 mg/L PBTK NA 50% Human Human -DTXSID3025203 Css NA 88.42 mg/L PBTK NA 95% Human Human +DTXSID3025203 Vd NA 0.1652 L/kg 1compartment NA NA Human Human +DTXSID3025203 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3025203 TK.Half.Life NA 10.21 hours 1compartment NA NA Human Human +DTXSID3025203 Css NA 6.276 mg/L 3compartmentss NA 50% Human Human +DTXSID3025203 Css NA 62.51 mg/L 3compartmentss NA 95% Human Human +DTXSID3025203 Css NA 3.632 mg/L PBTK NA 50% Human Human +DTXSID3025203 Css NA 36.13 mg/L PBTK NA 95% Human Human DTXSID3025203 Clint NA 6.303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3025203 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025203 Vd NA 0.1977 L/kg 1compartment NA NA Rat Human -DTXSID3025203 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3025203 TK.Half.Life NA 11.75 hours 1compartment NA NA Rat Human -DTXSID3025203 Css NA 9.304 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025203 Css NA 65.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025203 Css NA 5.094 mg/L PBTK NA 50% Rat Human -DTXSID3025203 Css NA 35.61 mg/L PBTK NA 95% Rat Human -DTXSID3025209 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025209 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025209 Vd NA 0.8619 L/kg 1compartment NA NA Human Human -DTXSID3025209 Days.Css NA 211 Days PBTK NA NA Human Human -DTXSID3025209 TK.Half.Life NA 812 hours 1compartment NA NA Human Human -DTXSID3025209 Css NA 158.4 mg/L 3compartmentss NA 50% Human Human -DTXSID3025209 Css NA 904.6 mg/L 3compartmentss NA 95% Human Human -DTXSID3025209 Css NA 94.46 mg/L PBTK NA 50% Human Human -DTXSID3025209 Css NA 527.5 mg/L PBTK NA 95% Human Human -DTXSID3025209 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025209 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025209 Vd NA 0.636 L/kg 1compartment NA NA Rat Human -DTXSID3025209 Days.Css NA 48 Days PBTK NA NA Rat Human -DTXSID3025209 TK.Half.Life NA 185.6 hours 1compartment NA NA Rat Human -DTXSID3025209 Css NA 44.59 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025209 Css NA 222 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025209 Css NA 24.91 mg/L PBTK NA 50% Rat Human -DTXSID3025209 Css NA 120.7 mg/L PBTK NA 95% Rat Human -DTXSID3025253 Clint NA 114.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025253 Fup NA 0.1189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025253 Vd NA 2.019 L/kg 1compartment NA NA Human Human +DTXSID3025203 Vd NA 0.1642 L/kg 1compartment NA NA Rat Human +DTXSID3025203 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3025203 TK.Half.Life NA 6.678 hours 1compartment NA NA Rat Human +DTXSID3025203 Css NA 0.06952 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025203 Css NA 0.5806 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025203 Css NA 0.03778 mg/L PBTK NA 50% Rat Human +DTXSID3025203 Css NA 0.3152 mg/L PBTK NA 95% Rat Human +DTXSID3025209 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025209 Fup 0.054 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025209 Vd NA 0.6353 L/kg 1compartment NA NA Human Human +DTXSID3025209 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3025209 TK.Half.Life NA 7.034 hours 1compartment NA NA Human Human +DTXSID3025209 Css NA 1.558 mg/L 3compartmentss NA 50% Human Human +DTXSID3025209 Css NA 10.98 mg/L 3compartmentss NA 95% Human Human +DTXSID3025209 Css NA 0.9569 mg/L PBTK NA 50% Human Human +DTXSID3025209 Css NA 6.473 mg/L PBTK NA 95% Human Human +DTXSID3025209 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025209 Fup 0.054 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025209 Vd NA 0.5048 L/kg 1compartment NA NA Rat Human +DTXSID3025209 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3025209 TK.Half.Life NA 3.368 hours 1compartment NA NA Rat Human +DTXSID3025209 Css NA 0.07244 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025209 Css NA 0.5722 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025209 Css NA 0.04286 mg/L PBTK NA 50% Rat Human +DTXSID3025209 Css NA 0.3293 mg/L PBTK NA 95% Rat Human +DTXSID3025253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025253 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025253 Vd NA 0.5962 L/kg 1compartment NA NA Human Human DTXSID3025253 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025253 TK.Half.Life NA 2.473 hours 1compartment NA NA Human Human -DTXSID3025253 Css NA 0.0614 mg/L 3compartmentss NA 50% Human Human -DTXSID3025253 Css NA 0.4668 mg/L 3compartmentss NA 95% Human Human -DTXSID3025253 Css NA 0.04222 mg/L PBTK NA 50% Human Human -DTXSID3025253 Css NA 0.3036 mg/L PBTK NA 95% Human Human -DTXSID3025253 Clint NA 114.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025253 Fup NA 0.1189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025253 Vd NA 1.535 L/kg 1compartment NA NA Rat Human +DTXSID3025253 TK.Half.Life NA 0.9624 hours 1compartment NA NA Human Human +DTXSID3025253 Css NA 0.08656 mg/L 3compartmentss NA 50% Human Human +DTXSID3025253 Css NA 0.6292 mg/L 3compartmentss NA 95% Human Human +DTXSID3025253 Css NA 0.05886 mg/L PBTK NA 50% Human Human +DTXSID3025253 Css NA 0.4139 mg/L PBTK NA 95% Human Human +DTXSID3025253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025253 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025253 Vd NA 0.5439 L/kg 1compartment NA NA Rat Human DTXSID3025253 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025253 TK.Half.Life NA 0.8242 hours 1compartment NA NA Rat Human -DTXSID3025253 Css NA 0.03429 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025253 Css NA 0.2113 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025253 Css NA 0.02237 mg/L PBTK NA 50% Rat Human -DTXSID3025253 Css NA 0.1303 mg/L PBTK NA 95% Rat Human -DTXSID3025257 Clint NA 13.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025257 Fup NA 0.029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025257 Vd NA 0.2958 L/kg 1compartment NA NA Human Human +DTXSID3025253 TK.Half.Life NA 0.481 hours 1compartment NA NA Rat Human +DTXSID3025253 Css NA 0.004207 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025253 Css NA 0.03444 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025253 Css NA 0.002826 mg/L PBTK NA 50% Rat Human +DTXSID3025253 Css NA 0.02103 mg/L PBTK NA 95% Rat Human +DTXSID3025257 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025257 Fup 0.0803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025257 Vd NA 0.4769 L/kg 1compartment NA NA Human Human DTXSID3025257 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025257 TK.Half.Life NA 3.156 hours 1compartment NA NA Human Human -DTXSID3025257 Css NA 1.828 mg/L 3compartmentss NA 50% Human Human -DTXSID3025257 Css NA 16.84 mg/L 3compartmentss NA 95% Human Human -DTXSID3025257 Css NA 1.11 mg/L PBTK NA 50% Human Human -DTXSID3025257 Css NA 9.825 mg/L PBTK NA 95% Human Human -DTXSID3025257 Clint NA 13.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025257 Fup NA 0.029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025257 Vd NA 0.2878 L/kg 1compartment NA NA Rat Human +DTXSID3025257 TK.Half.Life NA 3.713 hours 1compartment NA NA Human Human +DTXSID3025257 Css NA 1.118 mg/L 3compartmentss NA 50% Human Human +DTXSID3025257 Css NA 7.677 mg/L 3compartmentss NA 95% Human Human +DTXSID3025257 Css NA 0.7366 mg/L PBTK NA 50% Human Human +DTXSID3025257 Css NA 4.763 mg/L PBTK NA 95% Human Human +DTXSID3025257 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025257 Fup 0.0803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025257 Vd NA 0.4668 L/kg 1compartment NA NA Rat Human DTXSID3025257 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025257 TK.Half.Life NA 1.993 hours 1compartment NA NA Rat Human -DTXSID3025257 Css NA 1.022 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025257 Css NA 7.234 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025257 Css NA 0.58 mg/L PBTK NA 50% Rat Human -DTXSID3025257 Css NA 3.966 mg/L PBTK NA 95% Rat Human -DTXSID3025330 Clint NA 5.098 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025330 Fup NA 0.4073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025330 Vd NA 1.919 L/kg 1compartment NA NA Human Human +DTXSID3025257 TK.Half.Life NA 2.242 hours 1compartment NA NA Rat Human +DTXSID3025257 Css NA 0.1371 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025257 Css NA 0.7044 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025257 Css NA 0.0877 mg/L PBTK NA 50% Rat Human +DTXSID3025257 Css NA 0.4191 mg/L PBTK NA 95% Rat Human +DTXSID3025330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025330 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025330 Vd NA 1.061 L/kg 1compartment NA NA Human Human DTXSID3025330 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025330 TK.Half.Life NA 5.617 hours 1compartment NA NA Human Human -DTXSID3025330 Css NA 0.2626 mg/L 3compartmentss NA 50% Human Human -DTXSID3025330 Css NA 1.52 mg/L 3compartmentss NA 95% Human Human -DTXSID3025330 Css NA 0.2102 mg/L PBTK NA 50% Human Human -DTXSID3025330 Css NA 1.075 mg/L PBTK NA 95% Human Human -DTXSID3025330 Clint NA 5.098 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025330 Fup NA 0.4073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025330 Vd NA 1.539 L/kg 1compartment NA NA Rat Human +DTXSID3025330 TK.Half.Life NA 2.507 hours 1compartment NA NA Human Human +DTXSID3025330 Css NA 0.2373 mg/L 3compartmentss NA 50% Human Human +DTXSID3025330 Css NA 1.888 mg/L 3compartmentss NA 95% Human Human +DTXSID3025330 Css NA 0.155 mg/L PBTK NA 50% Human Human +DTXSID3025330 Css NA 1.188 mg/L PBTK NA 95% Human Human +DTXSID3025330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025330 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025330 Vd NA 0.8384 L/kg 1compartment NA NA Rat Human DTXSID3025330 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025330 TK.Half.Life NA 2.006 hours 1compartment NA NA Rat Human -DTXSID3025330 Css NA 0.1306 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025330 Css NA 0.5539 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025330 Css NA 0.1016 mg/L PBTK NA 50% Rat Human -DTXSID3025330 Css NA 0.3689 mg/L PBTK NA 95% Rat Human -DTXSID3025332 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025332 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025332 Vd NA 0.7205 L/kg 1compartment NA NA Human Human +DTXSID3025330 TK.Half.Life NA 1.081 hours 1compartment NA NA Rat Human +DTXSID3025330 Css NA 0.03048 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025330 Css NA 0.1909 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025330 Css NA 0.01956 mg/L PBTK NA 50% Rat Human +DTXSID3025330 Css NA 0.115 mg/L PBTK NA 95% Rat Human +DTXSID3025332 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025332 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025332 Vd NA 0.5294 L/kg 1compartment NA NA Human Human DTXSID3025332 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025332 TK.Half.Life NA 4.665 hours 1compartment NA NA Human Human -DTXSID3025332 Css NA 0.8424 mg/L 3compartmentss NA 50% Human Human -DTXSID3025332 Css NA 5.535 mg/L 3compartmentss NA 95% Human Human -DTXSID3025332 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID3025332 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID3025332 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025332 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025332 Vd NA 0.7663 L/kg 1compartment NA NA Rat Human +DTXSID3025332 TK.Half.Life NA 5.835 hours 1compartment NA NA Human Human +DTXSID3025332 Css NA 1.27 mg/L 3compartmentss NA 50% Human Human +DTXSID3025332 Css NA 8.522 mg/L 3compartmentss NA 95% Human Human +DTXSID3025332 Css NA 0.9668 mg/L PBTK NA 50% Human Human +DTXSID3025332 Css NA 5.325 mg/L PBTK NA 95% Human Human +DTXSID3025332 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025332 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025332 Vd NA 0.5612 L/kg 1compartment NA NA Rat Human DTXSID3025332 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025332 TK.Half.Life NA 1.689 hours 1compartment NA NA Rat Human -DTXSID3025332 Css NA 0.2117 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025332 Css NA 1.314 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025332 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID3025332 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID3025338 Clint NA 2.203 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025338 Fup NA 0.8073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025338 Vd NA 1.307 L/kg 1compartment NA NA Human Human +DTXSID3025332 TK.Half.Life NA 2.108 hours 1compartment NA NA Rat Human +DTXSID3025332 Css NA 0.07855 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025332 Css NA 0.4846 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025332 Css NA 0.05896 mg/L PBTK NA 50% Rat Human +DTXSID3025332 Css NA 0.29 mg/L PBTK NA 95% Rat Human +DTXSID3025338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025338 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025338 Vd NA 0.8394 L/kg 1compartment NA NA Human Human DTXSID3025338 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025338 TK.Half.Life NA 2.85 hours 1compartment NA NA Human Human -DTXSID3025338 Css NA 0.2076 mg/L 3compartmentss NA 50% Human Human -DTXSID3025338 Css NA 1.538 mg/L 3compartmentss NA 95% Human Human -DTXSID3025338 Css NA 0.1862 mg/L PBTK NA 50% Human Human -DTXSID3025338 Css NA 1.069 mg/L PBTK NA 95% Human Human -DTXSID3025338 Clint NA 2.203 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025338 Fup NA 0.8073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025338 Vd NA 1.203 L/kg 1compartment NA NA Rat Human +DTXSID3025338 TK.Half.Life NA 0.9623 hours 1compartment NA NA Human Human +DTXSID3025338 Css NA 0.05182 mg/L 3compartmentss NA 50% Human Human +DTXSID3025338 Css NA 0.4017 mg/L 3compartmentss NA 95% Human Human +DTXSID3025338 Css NA 0.03924 mg/L PBTK NA 50% Human Human +DTXSID3025338 Css NA 0.2808 mg/L PBTK NA 95% Human Human +DTXSID3025338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025338 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025338 Vd NA 0.7664 L/kg 1compartment NA NA Rat Human DTXSID3025338 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025338 TK.Half.Life NA 1.313 hours 1compartment NA NA Rat Human -DTXSID3025338 Css NA 0.0885 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025338 Css NA 0.6045 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025338 Css NA 0.07807 mg/L PBTK NA 50% Rat Human -DTXSID3025338 Css NA 0.381 mg/L PBTK NA 95% Rat Human -DTXSID3025465 Clint NA 313.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025465 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025465 Vd NA 5.846 L/kg 1compartment NA NA Human Human -DTXSID3025465 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025465 TK.Half.Life NA 15.97 hours 1compartment NA NA Human Human -DTXSID3025465 Css NA 0.2 mg/L 3compartmentss NA 50% Human Human -DTXSID3025465 Css NA 1.139 mg/L 3compartmentss NA 95% Human Human -DTXSID3025465 Css NA 0.1738 mg/L PBTK NA 50% Human Human -DTXSID3025465 Css NA 0.957 mg/L PBTK NA 95% Human Human -DTXSID3025465 Clint NA 313.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025465 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025465 Vd NA 4.493 L/kg 1compartment NA NA Rat Human -DTXSID3025465 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025465 TK.Half.Life NA 2.994 hours 1compartment NA NA Rat Human -DTXSID3025465 Css NA 0.1116 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025465 Css NA 0.494 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025465 Css NA 0.09436 mg/L PBTK NA 50% Rat Human -DTXSID3025465 Css NA 0.422 mg/L PBTK NA 95% Rat Human +DTXSID3025338 TK.Half.Life NA 0.4519 hours 1compartment NA NA Rat Human +DTXSID3025338 Css NA 0.00645 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025338 Css NA 0.03866 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025338 Css NA 0.004874 mg/L PBTK NA 50% Rat Human +DTXSID3025338 Css NA 0.02577 mg/L PBTK NA 95% Rat Human DTXSID3025469 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3025469 Fup NA 0.814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3025469 Vd NA 1.321 L/kg 1compartment NA NA Human Human DTXSID3025469 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID3025469 TK.Half.Life NA 11.4 hours 1compartment NA NA Human Human -DTXSID3025469 Css NA 0.9145 mg/L 3compartmentss NA 50% Human Human -DTXSID3025469 Css NA 5.849 mg/L 3compartmentss NA 95% Human Human -DTXSID3025469 Css NA 0.8348 mg/L PBTK NA 50% Human Human -DTXSID3025469 Css NA 3.923 mg/L PBTK NA 95% Human Human +DTXSID3025469 Css NA 0.7846 mg/L 3compartmentss NA 50% Human Human +DTXSID3025469 Css NA 5.258 mg/L 3compartmentss NA 95% Human Human +DTXSID3025469 Css NA 0.7154 mg/L PBTK NA 50% Human Human +DTXSID3025469 Css NA 3.471 mg/L PBTK NA 95% Human Human DTXSID3025469 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3025469 Fup NA 0.814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3025469 Vd NA 1.214 L/kg 1compartment NA NA Rat Human DTXSID3025469 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3025469 TK.Half.Life NA 3.357 hours 1compartment NA NA Rat Human -DTXSID3025469 Css NA 0.2346 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025469 Css NA 1.491 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025469 Css NA 0.209 mg/L PBTK NA 50% Rat Human -DTXSID3025469 Css NA 0.9237 mg/L PBTK NA 95% Rat Human -DTXSID3025540 Clint NA 3.545 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025540 Fup NA 0.0186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025540 Vd NA 0.4378 L/kg 1compartment NA NA Human Human -DTXSID3025540 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3025540 TK.Half.Life NA 21.4 hours 1compartment NA NA Human Human -DTXSID3025540 Css NA 8.571 mg/L 3compartmentss NA 50% Human Human -DTXSID3025540 Css NA 72.36 mg/L 3compartmentss NA 95% Human Human -DTXSID3025540 Css NA 5.329 mg/L PBTK NA 50% Human Human -DTXSID3025540 Css NA 42.5 mg/L PBTK NA 95% Human Human -DTXSID3025540 Clint NA 3.545 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025540 Fup NA 0.0186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025540 Vd NA 0.3892 L/kg 1compartment NA NA Rat Human -DTXSID3025540 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3025540 TK.Half.Life NA 11.46 hours 1compartment NA NA Rat Human -DTXSID3025540 Css NA 4.285 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025540 Css NA 28.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025540 Css NA 2.494 mg/L PBTK NA 50% Rat Human -DTXSID3025540 Css NA 15.61 mg/L PBTK NA 95% Rat Human +DTXSID3025469 Css NA 0.01447 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025469 Css NA 0.1142 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025469 Css NA 0.01289 mg/L PBTK NA 50% Rat Human +DTXSID3025469 Css NA 0.07917 mg/L PBTK NA 95% Rat Human DTXSID3025542 Clint NA 0.001328 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3025542 Fup NA 0.4524 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3025542 Vd NA 0.4455 L/kg 1compartment NA NA Human Human DTXSID3025542 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3025542 TK.Half.Life NA 6.359 hours 1compartment NA NA Human Human -DTXSID3025542 Css NA 1.65 mg/L 3compartmentss NA 50% Human Human -DTXSID3025542 Css NA 7.817 mg/L 3compartmentss NA 95% Human Human -DTXSID3025542 Css NA 1.195 mg/L PBTK NA 50% Human Human -DTXSID3025542 Css NA 4.833 mg/L PBTK NA 95% Human Human +DTXSID3025542 Css NA 1.388 mg/L 3compartmentss NA 50% Human Human +DTXSID3025542 Css NA 6.674 mg/L 3compartmentss NA 95% Human Human +DTXSID3025542 Css NA 1.012 mg/L PBTK NA 50% Human Human +DTXSID3025542 Css NA 4.158 mg/L PBTK NA 95% Human Human DTXSID3025542 Clint NA 0.001328 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3025542 Fup NA 0.4524 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3025542 Vd NA 0.4509 L/kg 1compartment NA NA Rat Human DTXSID3025542 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3025542 TK.Half.Life NA 2.195 hours 1compartment NA NA Rat Human -DTXSID3025542 Css NA 0.4494 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025542 Css NA 1.871 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025542 Css NA 0.3109 mg/L PBTK NA 50% Rat Human -DTXSID3025542 Css NA 1.091 mg/L PBTK NA 95% Rat Human -DTXSID3025548 Clint NA 8.817 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025548 Fup NA 0.0944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025548 Vd NA 3.124 L/kg 1compartment NA NA Human Human -DTXSID3025548 Days.Css NA 32 Days PBTK NA NA Human Human -DTXSID3025548 TK.Half.Life NA 169.3 hours 1compartment NA NA Human Human -DTXSID3025548 Css NA 6.584 mg/L 3compartmentss NA 50% Human Human -DTXSID3025548 Css NA 42.09 mg/L 3compartmentss NA 95% Human Human -DTXSID3025548 Css NA 4.563 mg/L PBTK NA 50% Human Human -DTXSID3025548 Css NA 28.33 mg/L PBTK NA 95% Human Human -DTXSID3025548 Clint NA 8.817 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025548 Fup NA 0.0944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025548 Vd NA 2.342 L/kg 1compartment NA NA Rat Human -DTXSID3025548 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID3025548 TK.Half.Life NA 22.17 hours 1compartment NA NA Rat Human -DTXSID3025548 Css NA 3.668 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025548 Css NA 18.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025548 Css NA 2.442 mg/L PBTK NA 50% Rat Human -DTXSID3025548 Css NA 11.76 mg/L PBTK NA 95% Rat Human -DTXSID3025629 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025629 Fup NA 0.5257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025629 Vd NA 1.437 L/kg 1compartment NA NA Human Human +DTXSID3025542 Css NA 0.02572 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025542 Css NA 0.1719 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025542 Css NA 0.01803 mg/L PBTK NA 50% Rat Human +DTXSID3025542 Css NA 0.1067 mg/L PBTK NA 95% Rat Human +DTXSID3025548 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025548 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025548 Vd NA 3.066 L/kg 1compartment NA NA Human Human +DTXSID3025548 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3025548 TK.Half.Life NA 20.34 hours 1compartment NA NA Human Human +DTXSID3025548 Css NA 0.6889 mg/L 3compartmentss NA 50% Human Human +DTXSID3025548 Css NA 4.314 mg/L 3compartmentss NA 95% Human Human +DTXSID3025548 Css NA 0.4921 mg/L PBTK NA 50% Human Human +DTXSID3025548 Css NA 2.965 mg/L PBTK NA 95% Human Human +DTXSID3025548 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025548 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025548 Vd NA 2.318 L/kg 1compartment NA NA Rat Human +DTXSID3025548 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3025548 TK.Half.Life NA 3.45 hours 1compartment NA NA Rat Human +DTXSID3025548 Css NA 0.08775 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025548 Css NA 0.4465 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025548 Css NA 0.06244 mg/L PBTK NA 50% Rat Human +DTXSID3025548 Css NA 0.3052 mg/L PBTK NA 95% Rat Human +DTXSID3025629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025629 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025629 Vd NA 0.7758 L/kg 1compartment NA NA Human Human DTXSID3025629 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025629 TK.Half.Life NA 1.706 hours 1compartment NA NA Human Human -DTXSID3025629 Css NA 0.06706 mg/L 3compartmentss NA 50% Human Human -DTXSID3025629 Css NA 0.5619 mg/L 3compartmentss NA 95% Human Human -DTXSID3025629 Css NA 0.05597 mg/L PBTK NA 50% Human Human -DTXSID3025629 Css NA 0.4051 mg/L PBTK NA 95% Human Human -DTXSID3025629 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025629 Fup NA 0.5257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025629 Vd NA 1.229 L/kg 1compartment NA NA Rat Human +DTXSID3025629 TK.Half.Life NA 1.067 hours 1compartment NA NA Human Human +DTXSID3025629 Css NA 0.0753 mg/L 3compartmentss NA 50% Human Human +DTXSID3025629 Css NA 0.5504 mg/L 3compartmentss NA 95% Human Human +DTXSID3025629 Css NA 0.05383 mg/L PBTK NA 50% Human Human +DTXSID3025629 Css NA 0.3655 mg/L PBTK NA 95% Human Human +DTXSID3025629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025629 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025629 Vd NA 0.6914 L/kg 1compartment NA NA Rat Human DTXSID3025629 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025629 TK.Half.Life NA 0.725 hours 1compartment NA NA Rat Human -DTXSID3025629 Css NA 0.03474 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025629 Css NA 0.2459 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025629 Css NA 0.02816 mg/L PBTK NA 50% Rat Human -DTXSID3025629 Css NA 0.1647 mg/L PBTK NA 95% Rat Human -DTXSID3025706 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025706 Fup NA 0.1613 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025706 Vd NA 0.3045 L/kg 1compartment NA NA Human Human -DTXSID3025706 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3025706 TK.Half.Life NA 12.21 hours 1compartment NA NA Human Human -DTXSID3025706 Css NA 5.576 mg/L 3compartmentss NA 50% Human Human -DTXSID3025706 Css NA 23.1 mg/L 3compartmentss NA 95% Human Human -DTXSID3025706 Css NA 3.495 mg/L PBTK NA 50% Human Human -DTXSID3025706 Css NA 13.63 mg/L PBTK NA 95% Human Human -DTXSID3025706 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025706 Fup NA 0.1613 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025706 Vd NA 0.3064 L/kg 1compartment NA NA Rat Human +DTXSID3025629 TK.Half.Life NA 0.5041 hours 1compartment NA NA Rat Human +DTXSID3025629 Css NA 0.009467 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025629 Css NA 0.05283 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025629 Css NA 0.006762 mg/L PBTK NA 50% Rat Human +DTXSID3025629 Css NA 0.03485 mg/L PBTK NA 95% Rat Human +DTXSID3025706 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025706 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025706 Vd NA 0.6887 L/kg 1compartment NA NA Human Human +DTXSID3025706 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3025706 TK.Half.Life NA 15.77 hours 1compartment NA NA Human Human +DTXSID3025706 Css NA 2.186 mg/L 3compartmentss NA 50% Human Human +DTXSID3025706 Css NA 8.858 mg/L 3compartmentss NA 95% Human Human +DTXSID3025706 Css NA 1.576 mg/L PBTK NA 50% Human Human +DTXSID3025706 Css NA 5.636 mg/L PBTK NA 95% Human Human +DTXSID3025706 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025706 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025706 Vd NA 0.6698 L/kg 1compartment NA NA Rat Human DTXSID3025706 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025706 TK.Half.Life NA 4.188 hours 1compartment NA NA Rat Human -DTXSID3025706 Css NA 1.576 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025706 Css NA 5.234 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025706 Css NA 0.9252 mg/L PBTK NA 50% Rat Human -DTXSID3025706 Css NA 2.905 mg/L PBTK NA 95% Rat Human -DTXSID3025758 Clint NA 9.638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025758 Fup NA 0.5777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025758 Vd NA 2.682 L/kg 1compartment NA NA Human Human -DTXSID3025758 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025758 TK.Half.Life NA 6.324 hours 1compartment NA NA Human Human -DTXSID3025758 Css NA 0.2012 mg/L 3compartmentss NA 50% Human Human -DTXSID3025758 Css NA 1.286 mg/L 3compartmentss NA 95% Human Human -DTXSID3025758 Css NA 0.161 mg/L PBTK NA 50% Human Human -DTXSID3025758 Css NA 0.9544 mg/L PBTK NA 95% Human Human -DTXSID3025758 Clint NA 9.638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025758 Fup NA 0.5777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025758 Vd NA 2.092 L/kg 1compartment NA NA Rat Human -DTXSID3025758 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025758 TK.Half.Life NA 1.67 hours 1compartment NA NA Rat Human -DTXSID3025758 Css NA 0.1049 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025758 Css NA 0.5242 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025758 Css NA 0.0818 mg/L PBTK NA 50% Rat Human -DTXSID3025758 Css NA 0.3655 mg/L PBTK NA 95% Rat Human -DTXSID3025881 Clint NA 28.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025881 Fup NA 0.969 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025881 Vd NA 0.9698 L/kg 1compartment NA NA Human Human +DTXSID3025706 TK.Half.Life NA 5.192 hours 1compartment NA NA Rat Human +DTXSID3025706 Css NA 0.03971 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025706 Css NA 0.2463 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025706 Css NA 0.0275 mg/L PBTK NA 50% Rat Human +DTXSID3025706 Css NA 0.1561 mg/L PBTK NA 95% Rat Human +DTXSID3025881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025881 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025881 Vd NA 0.7432 L/kg 1compartment NA NA Human Human DTXSID3025881 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025881 TK.Half.Life NA 0.6353 hours 1compartment NA NA Human Human -DTXSID3025881 Css NA 0.01892 mg/L 3compartmentss NA 50% Human Human -DTXSID3025881 Css NA 0.1977 mg/L 3compartmentss NA 95% Human Human -DTXSID3025881 Css NA 0.01623 mg/L PBTK NA 50% Human Human -DTXSID3025881 Css NA 0.1459 mg/L PBTK NA 95% Human Human -DTXSID3025881 Clint NA 28.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025881 Fup NA 0.969 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025881 Vd NA 0.9749 L/kg 1compartment NA NA Rat Human +DTXSID3025881 TK.Half.Life NA 7.73 hours 1compartment NA NA Human Human +DTXSID3025881 Css NA 1.145 mg/L 3compartmentss NA 50% Human Human +DTXSID3025881 Css NA 7.615 mg/L 3compartmentss NA 95% Human Human +DTXSID3025881 Css NA 0.9312 mg/L PBTK NA 50% Human Human +DTXSID3025881 Css NA 4.76 mg/L PBTK NA 95% Human Human +DTXSID3025881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025881 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025881 Vd NA 0.745 L/kg 1compartment NA NA Rat Human DTXSID3025881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025881 TK.Half.Life NA 0.2998 hours 1compartment NA NA Rat Human -DTXSID3025881 Css NA 0.009649 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025881 Css NA 0.08544 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025881 Css NA 0.00822 mg/L PBTK NA 50% Rat Human -DTXSID3025881 Css NA 0.0602 mg/L PBTK NA 95% Rat Human -DTXSID3025889 Clint NA 1.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025889 Fup NA 0.8178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3025889 Vd NA 1.097 L/kg 1compartment NA NA Human Human +DTXSID3025881 TK.Half.Life NA 2.628 hours 1compartment NA NA Rat Human +DTXSID3025881 Css NA 0.06952 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025881 Css NA 0.4504 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025881 Css NA 0.05612 mg/L PBTK NA 50% Rat Human +DTXSID3025881 Css NA 0.2748 mg/L PBTK NA 95% Rat Human +DTXSID3025889 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025889 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3025889 Vd NA 0.7491 L/kg 1compartment NA NA Human Human DTXSID3025889 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3025889 TK.Half.Life NA 3.271 hours 1compartment NA NA Human Human -DTXSID3025889 Css NA 0.3168 mg/L 3compartmentss NA 50% Human Human -DTXSID3025889 Css NA 2.2 mg/L 3compartmentss NA 95% Human Human -DTXSID3025889 Css NA 0.2768 mg/L PBTK NA 50% Human Human -DTXSID3025889 Css NA 1.476 mg/L PBTK NA 95% Human Human -DTXSID3025889 Clint NA 1.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025889 Fup NA 0.8178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3025889 Vd NA 1.049 L/kg 1compartment NA NA Rat Human +DTXSID3025889 TK.Half.Life NA 1.437 hours 1compartment NA NA Human Human +DTXSID3025889 Css NA 0.1456 mg/L 3compartmentss NA 50% Human Human +DTXSID3025889 Css NA 1.035 mg/L 3compartmentss NA 95% Human Human +DTXSID3025889 Css NA 0.1111 mg/L PBTK NA 50% Human Human +DTXSID3025889 Css NA 0.6949 mg/L PBTK NA 95% Human Human +DTXSID3025889 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025889 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3025889 Vd NA 0.7134 L/kg 1compartment NA NA Rat Human DTXSID3025889 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3025889 TK.Half.Life NA 1.51 hours 1compartment NA NA Rat Human -DTXSID3025889 Css NA 0.1222 mg/L 3compartmentss NA 50% Rat Human -DTXSID3025889 Css NA 0.797 mg/L 3compartmentss NA 95% Rat Human -DTXSID3025889 Css NA 0.1058 mg/L PBTK NA 50% Rat Human -DTXSID3025889 Css NA 0.4911 mg/L PBTK NA 95% Rat Human -DTXSID3026065 Clint NA 1.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026065 Fup NA 0.0552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026065 Vd NA 0.681 L/kg 1compartment NA NA Human Human -DTXSID3026065 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3026065 TK.Half.Life NA 19.87 hours 1compartment NA NA Human Human -DTXSID3026065 Css NA 4.426 mg/L 3compartmentss NA 50% Human Human -DTXSID3026065 Css NA 26.74 mg/L 3compartmentss NA 95% Human Human -DTXSID3026065 Css NA 3.019 mg/L PBTK NA 50% Human Human -DTXSID3026065 Css NA 16.1 mg/L PBTK NA 95% Human Human -DTXSID3026065 Clint NA 1.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026065 Fup NA 0.0552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026065 Vd NA 0.6155 L/kg 1compartment NA NA Rat Human -DTXSID3026065 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3026065 TK.Half.Life NA 9.781 hours 1compartment NA NA Rat Human -DTXSID3026065 Css NA 2.015 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026065 Css NA 9.652 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026065 Css NA 1.307 mg/L PBTK NA 50% Rat Human -DTXSID3026065 Css NA 5.519 mg/L PBTK NA 95% Rat Human -DTXSID3026067 Clint NA 15.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026067 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026067 Vd NA 0.5323 L/kg 1compartment NA NA Human Human +DTXSID3025889 TK.Half.Life NA 0.7547 hours 1compartment NA NA Rat Human +DTXSID3025889 Css NA 0.01706 mg/L 3compartmentss NA 50% Rat Human +DTXSID3025889 Css NA 0.09086 mg/L 3compartmentss NA 95% Rat Human +DTXSID3025889 Css NA 0.01308 mg/L PBTK NA 50% Rat Human +DTXSID3025889 Css NA 0.05888 mg/L PBTK NA 95% Rat Human +DTXSID3026065 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026065 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026065 Vd NA 0.2453 L/kg 1compartment NA NA Human Human +DTXSID3026065 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3026065 TK.Half.Life NA 0.4449 hours 1compartment NA NA Human Human +DTXSID3026065 Css NA 0.07343 mg/L 3compartmentss NA 50% Human Human +DTXSID3026065 Css NA 0.766 mg/L 3compartmentss NA 95% Human Human +DTXSID3026065 Css NA 0.04495 mg/L PBTK NA 50% Human Human +DTXSID3026065 Css NA 0.4457 mg/L PBTK NA 95% Human Human +DTXSID3026065 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026065 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026065 Vd NA 0.2553 L/kg 1compartment NA NA Rat Human +DTXSID3026065 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3026065 TK.Half.Life NA 0.2586 hours 1compartment NA NA Rat Human +DTXSID3026065 Css NA 0.0007638 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026065 Css NA 0.007222 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026065 Css NA 0.0004406 mg/L PBTK NA 50% Rat Human +DTXSID3026065 Css NA 0.004027 mg/L PBTK NA 95% Rat Human +DTXSID3026067 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026067 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026067 Vd NA 0.5447 L/kg 1compartment NA NA Human Human DTXSID3026067 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026067 TK.Half.Life NA 0.7684 hours 1compartment NA NA Human Human -DTXSID3026067 Css NA 0.08983 mg/L 3compartmentss NA 50% Human Human -DTXSID3026067 Css NA 0.6362 mg/L 3compartmentss NA 95% Human Human -DTXSID3026067 Css NA 0.06382 mg/L PBTK NA 50% Human Human -DTXSID3026067 Css NA 0.4195 mg/L PBTK NA 95% Human Human -DTXSID3026067 Clint NA 15.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026067 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026067 Vd NA 0.5254 L/kg 1compartment NA NA Rat Human +DTXSID3026067 TK.Half.Life NA 1.256 hours 1compartment NA NA Human Human +DTXSID3026067 Css NA 0.194 mg/L 3compartmentss NA 50% Human Human +DTXSID3026067 Css NA 1.249 mg/L 3compartmentss NA 95% Human Human +DTXSID3026067 Css NA 0.1388 mg/L PBTK NA 50% Human Human +DTXSID3026067 Css NA 0.8248 mg/L PBTK NA 95% Human Human +DTXSID3026067 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026067 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026067 Vd NA 0.5377 L/kg 1compartment NA NA Rat Human DTXSID3026067 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026067 TK.Half.Life NA 0.4092 hours 1compartment NA NA Rat Human -DTXSID3026067 Css NA 0.04868 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026067 Css NA 0.264 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026067 Css NA 0.03282 mg/L PBTK NA 50% Rat Human -DTXSID3026067 Css NA 0.1616 mg/L PBTK NA 95% Rat Human -DTXSID3026190 Clint NA 4.333 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026190 Fup NA 0.071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026190 Vd NA 1.491 L/kg 1compartment NA NA Human Human -DTXSID3026190 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3026190 TK.Half.Life NA 20.27 hours 1compartment NA NA Human Human -DTXSID3026190 Css NA 1.844 mg/L 3compartmentss NA 50% Human Human -DTXSID3026190 Css NA 10.19 mg/L 3compartmentss NA 95% Human Human -DTXSID3026190 Css NA 1.212 mg/L PBTK NA 50% Human Human -DTXSID3026190 Css NA 6.331 mg/L PBTK NA 95% Human Human -DTXSID3026190 Clint NA 4.333 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026190 Fup NA 0.071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026190 Vd NA 1.13 L/kg 1compartment NA NA Rat Human +DTXSID3026067 TK.Half.Life NA 0.699 hours 1compartment NA NA Rat Human +DTXSID3026067 Css NA 0.02298 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026067 Css NA 0.1092 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026067 Css NA 0.0163 mg/L PBTK NA 50% Rat Human +DTXSID3026067 Css NA 0.06902 mg/L PBTK NA 95% Rat Human +DTXSID3026190 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026190 Fup 0.0668 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026190 Vd NA 2.121 L/kg 1compartment NA NA Human Human +DTXSID3026190 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3026190 TK.Half.Life NA 9.867 hours 1compartment NA NA Human Human +DTXSID3026190 Css NA 0.5072 mg/L 3compartmentss NA 50% Human Human +DTXSID3026190 Css NA 3.393 mg/L 3compartmentss NA 95% Human Human +DTXSID3026190 Css NA 0.34 mg/L PBTK NA 50% Human Human +DTXSID3026190 Css NA 2.162 mg/L PBTK NA 95% Human Human +DTXSID3026190 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026190 Fup 0.0668 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026190 Vd NA 1.594 L/kg 1compartment NA NA Rat Human DTXSID3026190 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026190 TK.Half.Life NA 7.531 hours 1compartment NA NA Rat Human -DTXSID3026190 Css NA 0.957 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026190 Css NA 3.738 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026190 Css NA 0.5926 mg/L PBTK NA 50% Rat Human -DTXSID3026190 Css NA 2.205 mg/L PBTK NA 95% Rat Human +DTXSID3026190 TK.Half.Life NA 3.081 hours 1compartment NA NA Rat Human +DTXSID3026190 Css NA 0.06604 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026190 Css NA 0.3382 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026190 Css NA 0.04376 mg/L PBTK NA 50% Rat Human +DTXSID3026190 Css NA 0.216 mg/L PBTK NA 95% Rat Human DTXSID3026223 Clint 206 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3026223 Fup 0.895 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3026223 Vd NA 1.046 L/kg 1compartment NA NA Human Human +DTXSID3026223 Vd NA 1.009 L/kg 1compartment NA NA Human Human DTXSID3026223 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026223 TK.Half.Life NA 0.5859 hours 1compartment NA NA Human Human -DTXSID3026223 Css NA 0.00233 mg/L 3compartmentss NA 50% Human Human -DTXSID3026223 Css NA 0.0154 mg/L 3compartmentss NA 95% Human Human -DTXSID3026223 Css NA 0.002057 mg/L PBTK NA 50% Human Human -DTXSID3026223 Css NA 0.01236 mg/L PBTK NA 95% Human Human +DTXSID3026223 TK.Half.Life NA 0.5691 hours 1compartment NA NA Human Human +DTXSID3026223 Css NA 0.001289 mg/L 3compartmentss NA 50% Human Human +DTXSID3026223 Css NA 0.01366 mg/L 3compartmentss NA 95% Human Human +DTXSID3026223 Css NA 0.001126 mg/L PBTK NA 50% Human Human +DTXSID3026223 Css NA 0.01143 mg/L PBTK NA 95% Human Human DTXSID3026223 Clint 206 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3026223 Fup 0.895 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3026223 Vd NA 1.025 L/kg 1compartment NA NA Rat Human +DTXSID3026223 Vd NA 0.9949 L/kg 1compartment NA NA Rat Human DTXSID3026223 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026223 TK.Half.Life NA 0.2509 hours 1compartment NA NA Rat Human -DTXSID3026223 Css NA 0.001203 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026223 Css NA 0.007012 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026223 Css NA 0.001064 mg/L PBTK NA 50% Rat Human -DTXSID3026223 Css NA 0.005768 mg/L PBTK NA 95% Rat Human -DTXSID3026275 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026275 Fup NA 0.9357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026275 Vd NA 1.404 L/kg 1compartment NA NA Human Human -DTXSID3026275 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3026275 TK.Half.Life NA 10.58 hours 1compartment NA NA Human Human -DTXSID3026275 Css NA 0.8341 mg/L 3compartmentss NA 50% Human Human -DTXSID3026275 Css NA 4.889 mg/L 3compartmentss NA 95% Human Human -DTXSID3026275 Css NA 0.7758 mg/L PBTK NA 50% Human Human -DTXSID3026275 Css NA 3.365 mg/L PBTK NA 95% Human Human -DTXSID3026275 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026275 Fup NA 0.9357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026275 Vd NA 1.297 L/kg 1compartment NA NA Rat Human -DTXSID3026275 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026275 TK.Half.Life NA 3.121 hours 1compartment NA NA Rat Human -DTXSID3026275 Css NA 0.2114 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026275 Css NA 1.241 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026275 Css NA 0.1934 mg/L PBTK NA 50% Rat Human -DTXSID3026275 Css NA 0.7848 mg/L PBTK NA 95% Rat Human -DTXSID3026279 Clint NA 4.748 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026279 Fup NA 0.0686 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026279 Vd NA 2.572 L/kg 1compartment NA NA Human Human -DTXSID3026279 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID3026279 TK.Half.Life NA 61.02 hours 1compartment NA NA Human Human -DTXSID3026279 Css NA 3.254 mg/L 3compartmentss NA 50% Human Human -DTXSID3026279 Css NA 17.86 mg/L 3compartmentss NA 95% Human Human -DTXSID3026279 Css NA 2.204 mg/L PBTK NA 50% Human Human -DTXSID3026279 Css NA 11.57 mg/L PBTK NA 95% Human Human -DTXSID3026279 Clint NA 4.748 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026279 Fup NA 0.0686 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026279 Vd NA 1.931 L/kg 1compartment NA NA Rat Human -DTXSID3026279 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID3026279 TK.Half.Life NA 13.67 hours 1compartment NA NA Rat Human -DTXSID3026279 Css NA 1.706 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026279 Css NA 6.689 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026279 Css NA 1.106 mg/L PBTK NA 50% Rat Human -DTXSID3026279 Css NA 4.079 mg/L PBTK NA 95% Rat Human -DTXSID3026302 Clint NA 1.447 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026302 Fup NA 0.1808 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026302 Vd NA 0.3616 L/kg 1compartment NA NA Human Human -DTXSID3026302 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026302 TK.Half.Life NA 3.844 hours 1compartment NA NA Human Human -DTXSID3026302 Css NA 1.298 mg/L 3compartmentss NA 50% Human Human -DTXSID3026302 Css NA 5.78 mg/L 3compartmentss NA 95% Human Human -DTXSID3026302 Css NA 0.8509 mg/L PBTK NA 50% Human Human -DTXSID3026302 Css NA 3.519 mg/L PBTK NA 95% Human Human -DTXSID3026302 Clint NA 1.447 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026302 Fup NA 0.1808 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026302 Vd NA 0.3674 L/kg 1compartment NA NA Rat Human -DTXSID3026302 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026302 TK.Half.Life NA 2.062 hours 1compartment NA NA Rat Human -DTXSID3026302 Css NA 0.5751 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026302 Css NA 1.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026302 Css NA 0.3565 mg/L PBTK NA 50% Rat Human -DTXSID3026302 Css NA 1.098 mg/L PBTK NA 95% Rat Human -DTXSID3026304 Clint NA 3.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026304 Fup NA 0.4715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026304 Vd NA 1.482 L/kg 1compartment NA NA Human Human +DTXSID3026223 TK.Half.Life NA 0.2449 hours 1compartment NA NA Rat Human +DTXSID3026223 Css NA 0.0001665 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026223 Css NA 0.001516 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026223 Css NA 0.0001541 mg/L PBTK NA 50% Rat Human +DTXSID3026223 Css NA 0.001327 mg/L PBTK NA 95% Rat Human +DTXSID3026279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026279 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026279 Vd NA 1.431 L/kg 1compartment NA NA Human Human +DTXSID3026279 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3026279 TK.Half.Life NA 3.89 hours 1compartment NA NA Human Human +DTXSID3026279 Css NA 0.2908 mg/L 3compartmentss NA 50% Human Human +DTXSID3026279 Css NA 2.157 mg/L 3compartmentss NA 95% Human Human +DTXSID3026279 Css NA 0.1921 mg/L PBTK NA 50% Human Human +DTXSID3026279 Css NA 1.361 mg/L PBTK NA 95% Human Human +DTXSID3026279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026279 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026279 Vd NA 1.096 L/kg 1compartment NA NA Rat Human +DTXSID3026279 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3026279 TK.Half.Life NA 1.526 hours 1compartment NA NA Rat Human +DTXSID3026279 Css NA 0.03707 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026279 Css NA 0.2254 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026279 Css NA 0.02394 mg/L PBTK NA 50% Rat Human +DTXSID3026279 Css NA 0.1382 mg/L PBTK NA 95% Rat Human +DTXSID3026304 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026304 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026304 Vd NA 1.46 L/kg 1compartment NA NA Human Human DTXSID3026304 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026304 TK.Half.Life NA 4.533 hours 1compartment NA NA Human Human -DTXSID3026304 Css NA 0.2785 mg/L 3compartmentss NA 50% Human Human -DTXSID3026304 Css NA 1.682 mg/L 3compartmentss NA 95% Human Human -DTXSID3026304 Css NA 0.2298 mg/L PBTK NA 50% Human Human -DTXSID3026304 Css NA 1.168 mg/L PBTK NA 95% Human Human -DTXSID3026304 Clint NA 3.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026304 Fup NA 0.4715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026304 Vd NA 1.25 L/kg 1compartment NA NA Rat Human +DTXSID3026304 TK.Half.Life NA 1.849 hours 1compartment NA NA Human Human +DTXSID3026304 Css NA 0.06407 mg/L 3compartmentss NA 50% Human Human +DTXSID3026304 Css NA 0.4846 mg/L 3compartmentss NA 95% Human Human +DTXSID3026304 Css NA 0.04985 mg/L PBTK NA 50% Human Human +DTXSID3026304 Css NA 0.3423 mg/L PBTK NA 95% Human Human +DTXSID3026304 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026304 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026304 Vd NA 1.198 L/kg 1compartment NA NA Rat Human DTXSID3026304 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026304 TK.Half.Life NA 1.876 hours 1compartment NA NA Rat Human -DTXSID3026304 Css NA 0.1308 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026304 Css NA 0.6218 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026304 Css NA 0.1048 mg/L PBTK NA 50% Rat Human -DTXSID3026304 Css NA 0.4018 mg/L PBTK NA 95% Rat Human -DTXSID3026306 Clint NA 2.717 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026306 Fup NA 0.4292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026306 Vd NA 1.442 L/kg 1compartment NA NA Human Human +DTXSID3026304 TK.Half.Life NA 0.7448 hours 1compartment NA NA Rat Human +DTXSID3026304 Css NA 0.008032 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026304 Css NA 0.04675 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026304 Css NA 0.00623 mg/L PBTK NA 50% Rat Human +DTXSID3026304 Css NA 0.03308 mg/L PBTK NA 95% Rat Human +DTXSID3026306 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026306 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026306 Vd NA 1.384 L/kg 1compartment NA NA Human Human DTXSID3026306 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026306 TK.Half.Life NA 5.223 hours 1compartment NA NA Human Human -DTXSID3026306 Css NA 0.3439 mg/L 3compartmentss NA 50% Human Human -DTXSID3026306 Css NA 1.915 mg/L 3compartmentss NA 95% Human Human -DTXSID3026306 Css NA 0.2786 mg/L PBTK NA 50% Human Human -DTXSID3026306 Css NA 1.33 mg/L PBTK NA 95% Human Human -DTXSID3026306 Clint NA 2.717 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026306 Fup NA 0.4292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026306 Vd NA 1.209 L/kg 1compartment NA NA Rat Human +DTXSID3026306 TK.Half.Life NA 1.584 hours 1compartment NA NA Human Human +DTXSID3026306 Css NA 0.05212 mg/L 3compartmentss NA 50% Human Human +DTXSID3026306 Css NA 0.403 mg/L 3compartmentss NA 95% Human Human +DTXSID3026306 Css NA 0.04142 mg/L PBTK NA 50% Human Human +DTXSID3026306 Css NA 0.2875 mg/L PBTK NA 95% Human Human +DTXSID3026306 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026306 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026306 Vd NA 1.16 L/kg 1compartment NA NA Rat Human DTXSID3026306 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026306 TK.Half.Life NA 2.141 hours 1compartment NA NA Rat Human -DTXSID3026306 Css NA 0.1582 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026306 Css NA 0.6984 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026306 Css NA 0.1238 mg/L PBTK NA 50% Rat Human -DTXSID3026306 Css NA 0.4463 mg/L PBTK NA 95% Rat Human -DTXSID3026308 Clint NA 2.644 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026308 Fup NA 0.4264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026308 Vd NA 1.45 L/kg 1compartment NA NA Human Human +DTXSID3026306 TK.Half.Life NA 0.6539 hours 1compartment NA NA Rat Human +DTXSID3026306 Css NA 0.006408 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026306 Css NA 0.0401 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026306 Css NA 0.005133 mg/L PBTK NA 50% Rat Human +DTXSID3026306 Css NA 0.02835 mg/L PBTK NA 95% Rat Human +DTXSID3026308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026308 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026308 Vd NA 1.364 L/kg 1compartment NA NA Human Human DTXSID3026308 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026308 TK.Half.Life NA 5.394 hours 1compartment NA NA Human Human -DTXSID3026308 Css NA 0.3526 mg/L 3compartmentss NA 50% Human Human -DTXSID3026308 Css NA 1.983 mg/L 3compartmentss NA 95% Human Human -DTXSID3026308 Css NA 0.2865 mg/L PBTK NA 50% Human Human -DTXSID3026308 Css NA 1.389 mg/L PBTK NA 95% Human Human -DTXSID3026308 Clint NA 2.644 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026308 Fup NA 0.4264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026308 Vd NA 1.216 L/kg 1compartment NA NA Rat Human +DTXSID3026308 TK.Half.Life NA 1.6 hours 1compartment NA NA Human Human +DTXSID3026308 Css NA 0.05566 mg/L 3compartmentss NA 50% Human Human +DTXSID3026308 Css NA 0.4117 mg/L 3compartmentss NA 95% Human Human +DTXSID3026308 Css NA 0.04352 mg/L PBTK NA 50% Human Human +DTXSID3026308 Css NA 0.2921 mg/L PBTK NA 95% Human Human +DTXSID3026308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026308 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026308 Vd NA 1.142 L/kg 1compartment NA NA Rat Human DTXSID3026308 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026308 TK.Half.Life NA 2.203 hours 1compartment NA NA Rat Human -DTXSID3026308 Css NA 0.1632 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026308 Css NA 0.7162 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026308 Css NA 0.1281 mg/L PBTK NA 50% Rat Human -DTXSID3026308 Css NA 0.4525 mg/L PBTK NA 95% Rat Human -DTXSID3026512 Clint NA 117 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026512 Fup NA 0.004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026512 Vd NA 784.9 L/kg 1compartment NA NA Human Human -DTXSID3026512 Days.Css NA 1165 Days PBTK NA NA Human Human -DTXSID3026512 TK.Half.Life NA 4395 hours 1compartment NA NA Human Human -DTXSID3026512 Css NA 0.003794 mg/L 3compartmentss NA 50% Human Human -DTXSID3026512 Css NA 0.02326 mg/L 3compartmentss NA 95% Human Human -DTXSID3026512 Css NA 0.4662 mg/L PBTK NA 50% Human Human -DTXSID3026512 Css NA 2.647 mg/L PBTK NA 95% Human Human -DTXSID3026512 Clint NA 117 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026512 Fup NA 0.004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026512 Vd NA 715.7 L/kg 1compartment NA NA Rat Human -DTXSID3026512 Days.Css NA 772 Days PBTK NA NA Rat Human -DTXSID3026512 TK.Half.Life NA 742.4 hours 1compartment NA NA Rat Human -DTXSID3026512 Css NA 0.00193 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026512 Css NA 0.008307 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026512 Css NA 0.2511 mg/L PBTK NA 50% Rat Human -DTXSID3026512 Css NA 1.114 mg/L PBTK NA 95% Rat Human -DTXSID3026514 Clint NA 0.04196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026514 Fup NA 0.3132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026514 Vd NA 0.4814 L/kg 1compartment NA NA Human Human -DTXSID3026514 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026514 TK.Half.Life NA 9.371 hours 1compartment NA NA Human Human -DTXSID3026514 Css NA 2.267 mg/L 3compartmentss NA 50% Human Human -DTXSID3026514 Css NA 9.237 mg/L 3compartmentss NA 95% Human Human -DTXSID3026514 Css NA 1.574 mg/L PBTK NA 50% Human Human -DTXSID3026514 Css NA 5.733 mg/L PBTK NA 95% Human Human -DTXSID3026514 Clint NA 0.04196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026514 Fup NA 0.3132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026514 Vd NA 0.4599 L/kg 1compartment NA NA Rat Human +DTXSID3026308 TK.Half.Life NA 0.6627 hours 1compartment NA NA Rat Human +DTXSID3026308 Css NA 0.00682 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026308 Css NA 0.0399 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026308 Css NA 0.005395 mg/L PBTK NA 50% Rat Human +DTXSID3026308 Css NA 0.02832 mg/L PBTK NA 95% Rat Human +DTXSID3026514 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026514 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026514 Vd NA 1.069 L/kg 1compartment NA NA Human Human +DTXSID3026514 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3026514 TK.Half.Life NA 19.37 hours 1compartment NA NA Human Human +DTXSID3026514 Css NA 1.855 mg/L 3compartmentss NA 50% Human Human +DTXSID3026514 Css NA 7.829 mg/L 3compartmentss NA 95% Human Human +DTXSID3026514 Css NA 1.459 mg/L PBTK NA 50% Human Human +DTXSID3026514 Css NA 5.21 mg/L PBTK NA 95% Human Human +DTXSID3026514 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026514 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026514 Vd NA 0.9331 L/kg 1compartment NA NA Rat Human DTXSID3026514 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026514 TK.Half.Life NA 3.138 hours 1compartment NA NA Rat Human -DTXSID3026514 Css NA 0.6592 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026514 Css NA 2.222 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026514 Css NA 0.432 mg/L PBTK NA 50% Rat Human -DTXSID3026514 Css NA 1.286 mg/L PBTK NA 95% Rat Human -DTXSID3026516 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026516 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026516 Vd NA 1.015 L/kg 1compartment NA NA Human Human -DTXSID3026516 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026516 TK.Half.Life NA 6.652 hours 1compartment NA NA Human Human -DTXSID3026516 Css NA 0.7783 mg/L 3compartmentss NA 50% Human Human -DTXSID3026516 Css NA 5.511 mg/L 3compartmentss NA 95% Human Human -DTXSID3026516 Css NA 0.6981 mg/L PBTK NA 50% Human Human -DTXSID3026516 Css NA 3.684 mg/L PBTK NA 95% Human Human -DTXSID3026516 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026516 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026516 Vd NA 1.015 L/kg 1compartment NA NA Rat Human +DTXSID3026514 TK.Half.Life NA 5.403 hours 1compartment NA NA Rat Human +DTXSID3026514 Css NA 0.1184 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026514 Css NA 0.4411 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026514 Css NA 0.09202 mg/L PBTK NA 50% Rat Human +DTXSID3026514 Css NA 0.2786 mg/L PBTK NA 95% Rat Human +DTXSID3026516 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026516 Fup 0.461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026516 Vd NA 1.186 L/kg 1compartment NA NA Human Human +DTXSID3026516 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3026516 TK.Half.Life NA 18.46 hours 1compartment NA NA Human Human +DTXSID3026516 Css NA 1.543 mg/L 3compartmentss NA 50% Human Human +DTXSID3026516 Css NA 7.095 mg/L 3compartmentss NA 95% Human Human +DTXSID3026516 Css NA 1.26 mg/L PBTK NA 50% Human Human +DTXSID3026516 Css NA 4.672 mg/L PBTK NA 95% Human Human +DTXSID3026516 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026516 Fup 0.461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026516 Vd NA 1.036 L/kg 1compartment NA NA Rat Human DTXSID3026516 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026516 TK.Half.Life NA 2.245 hours 1compartment NA NA Rat Human -DTXSID3026516 Css NA 0.1966 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026516 Css NA 1.246 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026516 Css NA 0.1729 mg/L PBTK NA 50% Rat Human -DTXSID3026516 Css NA 0.7683 mg/L PBTK NA 95% Rat Human -DTXSID3026560 Clint NA 9.563 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026560 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026560 Vd NA 0.2175 L/kg 1compartment NA NA Human Human +DTXSID3026516 TK.Half.Life NA 5.082 hours 1compartment NA NA Rat Human +DTXSID3026516 Css NA 0.09723 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026516 Css NA 0.4105 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026516 Css NA 0.07918 mg/L PBTK NA 50% Rat Human +DTXSID3026516 Css NA 0.2613 mg/L PBTK NA 95% Rat Human +DTXSID3026560 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026560 Fup 0.0586 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026560 Vd NA 0.3621 L/kg 1compartment NA NA Human Human DTXSID3026560 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026560 TK.Half.Life NA 6.412 hours 1compartment NA NA Human Human -DTXSID3026560 Css NA 5.478 mg/L 3compartmentss NA 50% Human Human -DTXSID3026560 Css NA 46.9 mg/L 3compartmentss NA 95% Human Human -DTXSID3026560 Css NA 3.245 mg/L PBTK NA 50% Human Human -DTXSID3026560 Css NA 27.33 mg/L PBTK NA 95% Human Human -DTXSID3026560 Clint NA 9.563 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026560 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026560 Vd NA 0.2118 L/kg 1compartment NA NA Rat Human +DTXSID3026560 TK.Half.Life NA 1.387 hours 1compartment NA NA Human Human +DTXSID3026560 Css NA 0.5115 mg/L 3compartmentss NA 50% Human Human +DTXSID3026560 Css NA 4.069 mg/L 3compartmentss NA 95% Human Human +DTXSID3026560 Css NA 0.3218 mg/L PBTK NA 50% Human Human +DTXSID3026560 Css NA 2.469 mg/L PBTK NA 95% Human Human +DTXSID3026560 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026560 Fup 0.0586 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026560 Vd NA 0.3534 L/kg 1compartment NA NA Rat Human DTXSID3026560 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026560 TK.Half.Life NA 4.077 hours 1compartment NA NA Rat Human -DTXSID3026560 Css NA 2.97 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026560 Css NA 20.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026560 Css NA 1.638 mg/L PBTK NA 50% Rat Human -DTXSID3026560 Css NA 11.12 mg/L PBTK NA 95% Rat Human -DTXSID3026562 Clint NA 4.846 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026562 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026562 Vd NA 1.003 L/kg 1compartment NA NA Human Human +DTXSID3026560 TK.Half.Life NA 0.8441 hours 1compartment NA NA Rat Human +DTXSID3026560 Css NA 0.06653 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026560 Css NA 0.4265 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026560 Css NA 0.04045 mg/L PBTK NA 50% Rat Human +DTXSID3026560 Css NA 0.2482 mg/L PBTK NA 95% Rat Human +DTXSID3026562 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026562 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026562 Vd NA 0.6814 L/kg 1compartment NA NA Human Human DTXSID3026562 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026562 TK.Half.Life NA 2.066 hours 1compartment NA NA Human Human -DTXSID3026562 Css NA 0.1702 mg/L 3compartmentss NA 50% Human Human -DTXSID3026562 Css NA 1.193 mg/L 3compartmentss NA 95% Human Human -DTXSID3026562 Css NA 0.137 mg/L PBTK NA 50% Human Human -DTXSID3026562 Css NA 0.8113 mg/L PBTK NA 95% Human Human -DTXSID3026562 Clint NA 4.846 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026562 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026562 Vd NA 0.9108 L/kg 1compartment NA NA Rat Human +DTXSID3026562 TK.Half.Life NA 0.8233 hours 1compartment NA NA Human Human +DTXSID3026562 Css NA 0.05679 mg/L 3compartmentss NA 50% Human Human +DTXSID3026562 Css NA 0.4295 mg/L 3compartmentss NA 95% Human Human +DTXSID3026562 Css NA 0.04144 mg/L PBTK NA 50% Human Human +DTXSID3026562 Css NA 0.2907 mg/L PBTK NA 95% Human Human +DTXSID3026562 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026562 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026562 Vd NA 0.6436 L/kg 1compartment NA NA Rat Human DTXSID3026562 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026562 TK.Half.Life NA 1.011 hours 1compartment NA NA Rat Human -DTXSID3026562 Css NA 0.08328 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026562 Css NA 0.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026562 Css NA 0.06485 mg/L PBTK NA 50% Rat Human -DTXSID3026562 Css NA 0.297 mg/L PBTK NA 95% Rat Human +DTXSID3026562 TK.Half.Life NA 0.4051 hours 1compartment NA NA Rat Human +DTXSID3026562 Css NA 0.007206 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026562 Css NA 0.04182 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026562 Css NA 0.005227 mg/L PBTK NA 50% Rat Human +DTXSID3026562 Css NA 0.0283 mg/L PBTK NA 95% Rat Human DTXSID3026564 Clint 22.62 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3026564 Fup NA 0.0194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026564 Vd NA 1.658 L/kg 1compartment NA NA Human Human -DTXSID3026564 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3026564 TK.Half.Life NA 15.42 hours 1compartment NA NA Human Human -DTXSID3026564 Css NA 1.47 mg/L 3compartmentss NA 50% Human Human -DTXSID3026564 Css NA 12.67 mg/L 3compartmentss NA 95% Human Human -DTXSID3026564 Css NA 0.925 mg/L PBTK NA 50% Human Human -DTXSID3026564 Css NA 7.548 mg/L PBTK NA 95% Human Human +DTXSID3026564 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026564 Vd NA 3.63 L/kg 1compartment NA NA Human Human +DTXSID3026564 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID3026564 TK.Half.Life NA 105.6 hours 1compartment NA NA Human Human +DTXSID3026564 Css NA 1.74 mg/L 3compartmentss NA 50% Human Human +DTXSID3026564 Css NA 10.81 mg/L 3compartmentss NA 95% Human Human +DTXSID3026564 Css NA 1.255 mg/L PBTK NA 50% Human Human +DTXSID3026564 Css NA 7.712 mg/L PBTK NA 95% Human Human DTXSID3026564 Clint 22.62 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3026564 Fup NA 0.0194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026564 Vd NA 1.23 L/kg 1compartment NA NA Rat Human -DTXSID3026564 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026564 TK.Half.Life NA 5.645 hours 1compartment NA NA Rat Human -DTXSID3026564 Css NA 0.8128 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026564 Css NA 5.616 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026564 Css NA 0.4828 mg/L PBTK NA 50% Rat Human -DTXSID3026564 Css NA 3.185 mg/L PBTK NA 95% Rat Human -DTXSID3026566 Clint NA 0.1073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026566 Fup NA 0.578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026566 Vd NA 1.383 L/kg 1compartment NA NA Human Human -DTXSID3026566 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3026566 TK.Half.Life NA 15.04 hours 1compartment NA NA Human Human -DTXSID3026566 Css NA 1.084 mg/L 3compartmentss NA 50% Human Human -DTXSID3026566 Css NA 6.958 mg/L 3compartmentss NA 95% Human Human -DTXSID3026566 Css NA 0.9366 mg/L PBTK NA 50% Human Human -DTXSID3026566 Css NA 4.544 mg/L PBTK NA 95% Human Human -DTXSID3026566 Clint NA 0.1073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026566 Fup NA 0.578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026566 Vd NA 1.205 L/kg 1compartment NA NA Rat Human +DTXSID3026564 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026564 Vd NA 2.735 L/kg 1compartment NA NA Rat Human +DTXSID3026564 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID3026564 TK.Half.Life NA 14.42 hours 1compartment NA NA Rat Human +DTXSID3026564 Css NA 0.01885 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026564 Css NA 0.1126 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026564 Css NA 0.01322 mg/L PBTK NA 50% Rat Human +DTXSID3026564 Css NA 0.07791 mg/L PBTK NA 95% Rat Human +DTXSID3026566 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026566 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026566 Vd NA 2.035 L/kg 1compartment NA NA Human Human +DTXSID3026566 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3026566 TK.Half.Life NA 2.468 hours 1compartment NA NA Human Human +DTXSID3026566 Css NA 0.06098 mg/L 3compartmentss NA 50% Human Human +DTXSID3026566 Css NA 0.4465 mg/L 3compartmentss NA 95% Human Human +DTXSID3026566 Css NA 0.04936 mg/L PBTK NA 50% Human Human +DTXSID3026566 Css NA 0.321 mg/L PBTK NA 95% Human Human +DTXSID3026566 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026566 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026566 Vd NA 1.629 L/kg 1compartment NA NA Rat Human DTXSID3026566 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026566 TK.Half.Life NA 4.37 hours 1compartment NA NA Rat Human -DTXSID3026566 Css NA 0.3226 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026566 Css NA 2.011 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026566 Css NA 0.2682 mg/L PBTK NA 50% Rat Human -DTXSID3026566 Css NA 1.211 mg/L PBTK NA 95% Rat Human -DTXSID3026641 Clint NA 0.2088 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026641 Fup NA 0.2286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026641 Vd NA 1.517 L/kg 1compartment NA NA Human Human -DTXSID3026641 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID3026641 TK.Half.Life NA 41.21 hours 1compartment NA NA Human Human -DTXSID3026641 Css NA 3.005 mg/L 3compartmentss NA 50% Human Human -DTXSID3026641 Css NA 10.35 mg/L 3compartmentss NA 95% Human Human -DTXSID3026641 Css NA 2.202 mg/L PBTK NA 50% Human Human -DTXSID3026641 Css NA 6.782 mg/L PBTK NA 95% Human Human -DTXSID3026641 Clint NA 0.2088 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026641 Fup NA 0.2286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026641 Vd NA 1.204 L/kg 1compartment NA NA Rat Human -DTXSID3026641 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3026641 TK.Half.Life NA 10.56 hours 1compartment NA NA Rat Human -DTXSID3026641 Css NA 0.9694 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026641 Css NA 2.918 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026641 Css NA 0.6796 mg/L PBTK NA 50% Rat Human -DTXSID3026641 Css NA 1.758 mg/L PBTK NA 95% Rat Human +DTXSID3026566 TK.Half.Life NA 0.8753 hours 1compartment NA NA Rat Human +DTXSID3026566 Css NA 0.007609 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026566 Css NA 0.04384 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026566 Css NA 0.00616 mg/L PBTK NA 50% Rat Human +DTXSID3026566 Css NA 0.03196 mg/L PBTK NA 95% Rat Human +DTXSID3026641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026641 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026641 Vd NA 0.5602 L/kg 1compartment NA NA Human Human +DTXSID3026641 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3026641 TK.Half.Life NA 1.227 hours 1compartment NA NA Human Human +DTXSID3026641 Css NA 0.2104 mg/L 3compartmentss NA 50% Human Human +DTXSID3026641 Css NA 1.772 mg/L 3compartmentss NA 95% Human Human +DTXSID3026641 Css NA 0.1338 mg/L PBTK NA 50% Human Human +DTXSID3026641 Css NA 1.078 mg/L PBTK NA 95% Human Human +DTXSID3026641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026641 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026641 Vd NA 0.489 L/kg 1compartment NA NA Rat Human +DTXSID3026641 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3026641 TK.Half.Life NA 0.6145 hours 1compartment NA NA Rat Human +DTXSID3026641 Css NA 0.02719 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026641 Css NA 0.1778 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026641 Css NA 0.01694 mg/L PBTK NA 50% Rat Human +DTXSID3026641 Css NA 0.1064 mg/L PBTK NA 95% Rat Human DTXSID3026647 Clint NA 0.009632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3026647 Fup NA 0.1761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3026647 Vd NA 0.338 L/kg 1compartment NA NA Human Human DTXSID3026647 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID3026647 TK.Half.Life NA 12.22 hours 1compartment NA NA Human Human -DTXSID3026647 Css NA 4.58 mg/L 3compartmentss NA 50% Human Human -DTXSID3026647 Css NA 17.22 mg/L 3compartmentss NA 95% Human Human -DTXSID3026647 Css NA 2.987 mg/L PBTK NA 50% Human Human -DTXSID3026647 Css NA 10.38 mg/L PBTK NA 95% Human Human +DTXSID3026647 Css NA 4.451 mg/L 3compartmentss NA 50% Human Human +DTXSID3026647 Css NA 17.38 mg/L 3compartmentss NA 95% Human Human +DTXSID3026647 Css NA 2.909 mg/L PBTK NA 50% Human Human +DTXSID3026647 Css NA 10.49 mg/L PBTK NA 95% Human Human DTXSID3026647 Clint NA 0.009632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3026647 Fup NA 0.1761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3026647 Vd NA 0.3363 L/kg 1compartment NA NA Rat Human DTXSID3026647 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3026647 TK.Half.Life NA 4.178 hours 1compartment NA NA Rat Human -DTXSID3026647 Css NA 1.316 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026647 Css NA 4.128 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026647 Css NA 0.8082 mg/L PBTK NA 50% Rat Human -DTXSID3026647 Css NA 2.336 mg/L PBTK NA 95% Rat Human +DTXSID3026647 Css NA 0.2932 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026647 Css NA 0.9416 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026647 Css NA 0.1867 mg/L PBTK NA 50% Rat Human +DTXSID3026647 Css NA 0.5515 mg/L PBTK NA 95% Rat Human DTXSID3026697 Clint 3.152 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3026697 Fup 0.03126 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3026697 Vd NA 711.5 L/kg 1compartment NA NA Human Human -DTXSID3026697 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID3026697 TK.Half.Life NA 142900 hours 1compartment NA NA Human Human -DTXSID3026697 Css NA 0.1506 mg/L 3compartmentss NA 50% Human Human -DTXSID3026697 Css NA 0.9191 mg/L 3compartmentss NA 95% Human Human -DTXSID3026697 Css NA 16.51 mg/L PBTK NA 50% Human Human -DTXSID3026697 Css NA 94.44 mg/L PBTK NA 95% Human Human +DTXSID3026697 Vd NA 7.979 L/kg 1compartment NA NA Human Human +DTXSID3026697 Days.Css NA 414 Days PBTK NA NA Human Human +DTXSID3026697 TK.Half.Life NA 1607 hours 1compartment NA NA Human Human +DTXSID3026697 Css NA 15.6 mg/L 3compartmentss NA 50% Human Human +DTXSID3026697 Css NA 96.51 mg/L 3compartmentss NA 95% Human Human +DTXSID3026697 Css NA 16.13 mg/L PBTK NA 50% Human Human +DTXSID3026697 Css NA 96.83 mg/L PBTK NA 95% Human Human DTXSID3026697 Clint 3.152 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3026697 Fup 0.03126 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3026697 Vd NA 647.6 L/kg 1compartment NA NA Rat Human -DTXSID3026697 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID3026697 TK.Half.Life NA 21980 hours 1compartment NA NA Rat Human -DTXSID3026697 Css NA 0.0755 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026697 Css NA 0.3132 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026697 Css NA 9.022 mg/L PBTK NA 50% Rat Human -DTXSID3026697 Css NA 37.37 mg/L PBTK NA 95% Rat Human -DTXSID3026724 Clint NA 181.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026724 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026724 Vd NA 1.343 L/kg 1compartment NA NA Human Human +DTXSID3026697 Vd NA 6.219 L/kg 1compartment NA NA Rat Human +DTXSID3026697 Days.Css NA 231 Days PBTK NA NA Rat Human +DTXSID3026697 TK.Half.Life NA 212.6 hours 1compartment NA NA Rat Human +DTXSID3026697 Css NA 1.974 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026697 Css NA 9.072 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026697 Css NA 2.084 mg/L PBTK NA 50% Rat Human +DTXSID3026697 Css NA 9.88 mg/L PBTK NA 95% Rat Human +DTXSID3026724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026724 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026724 Vd NA 2.846 L/kg 1compartment NA NA Human Human DTXSID3026724 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026724 TK.Half.Life NA 1.367 hours 1compartment NA NA Human Human -DTXSID3026724 Css NA 0.02986 mg/L 3compartmentss NA 50% Human Human -DTXSID3026724 Css NA 0.2449 mg/L 3compartmentss NA 95% Human Human -DTXSID3026724 Css NA 0.02001 mg/L PBTK NA 50% Human Human -DTXSID3026724 Css NA 0.1567 mg/L PBTK NA 95% Human Human -DTXSID3026724 Clint NA 181.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026724 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026724 Vd NA 1.043 L/kg 1compartment NA NA Rat Human +DTXSID3026724 TK.Half.Life NA 9.608 hours 1compartment NA NA Human Human +DTXSID3026724 Css NA 0.3079 mg/L 3compartmentss NA 50% Human Human +DTXSID3026724 Css NA 1.928 mg/L 3compartmentss NA 95% Human Human +DTXSID3026724 Css NA 0.2234 mg/L PBTK NA 50% Human Human +DTXSID3026724 Css NA 1.346 mg/L PBTK NA 95% Human Human +DTXSID3026724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026724 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026724 Vd NA 2.159 L/kg 1compartment NA NA Rat Human DTXSID3026724 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026724 TK.Half.Life NA 0.4909 hours 1compartment NA NA Rat Human -DTXSID3026724 Css NA 0.01712 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026724 Css NA 0.1119 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026724 Css NA 0.01082 mg/L PBTK NA 50% Rat Human -DTXSID3026724 Css NA 0.06673 mg/L PBTK NA 95% Rat Human -DTXSID3026726 Clint NA 17.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026726 Fup NA 0.1796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026726 Vd NA 2.998 L/kg 1compartment NA NA Human Human -DTXSID3026726 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3026726 TK.Half.Life NA 23.9 hours 1compartment NA NA Human Human -DTXSID3026726 Css NA 0.8785 mg/L 3compartmentss NA 50% Human Human -DTXSID3026726 Css NA 5.096 mg/L 3compartmentss NA 95% Human Human -DTXSID3026726 Css NA 0.623 mg/L PBTK NA 50% Human Human -DTXSID3026726 Css NA 3.496 mg/L PBTK NA 95% Human Human -DTXSID3026726 Clint NA 17.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026726 Fup NA 0.1796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026726 Vd NA 2.257 L/kg 1compartment NA NA Rat Human +DTXSID3026724 TK.Half.Life NA 2.132 hours 1compartment NA NA Rat Human +DTXSID3026724 Css NA 0.03888 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026724 Css NA 0.187 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026724 Css NA 0.0282 mg/L PBTK NA 50% Rat Human +DTXSID3026724 Css NA 0.1326 mg/L PBTK NA 95% Rat Human +DTXSID3026726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026726 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026726 Vd NA 2.985 L/kg 1compartment NA NA Human Human +DTXSID3026726 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3026726 TK.Half.Life NA 19.46 hours 1compartment NA NA Human Human +DTXSID3026726 Css NA 0.6732 mg/L 3compartmentss NA 50% Human Human +DTXSID3026726 Css NA 4.271 mg/L 3compartmentss NA 95% Human Human +DTXSID3026726 Css NA 0.479 mg/L PBTK NA 50% Human Human +DTXSID3026726 Css NA 2.914 mg/L PBTK NA 95% Human Human +DTXSID3026726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026726 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026726 Vd NA 2.248 L/kg 1compartment NA NA Rat Human DTXSID3026726 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3026726 TK.Half.Life NA 4.136 hours 1compartment NA NA Rat Human -DTXSID3026726 Css NA 0.4826 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026726 Css NA 2.299 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026726 Css NA 0.327 mg/L PBTK NA 50% Rat Human -DTXSID3026726 Css NA 1.538 mg/L PBTK NA 95% Rat Human +DTXSID3026726 TK.Half.Life NA 3.495 hours 1compartment NA NA Rat Human +DTXSID3026726 Css NA 0.08734 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026726 Css NA 0.4363 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026726 Css NA 0.06166 mg/L PBTK NA 50% Rat Human +DTXSID3026726 Css NA 0.2978 mg/L PBTK NA 95% Rat Human DTXSID3026728 Clint 1.57 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID3026728 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID3026728 Clint 1.57 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID3026728 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID3026851 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026851 Fup NA 0.9962 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026851 Vd NA 0.9886 L/kg 1compartment NA NA Human Human +DTXSID3026851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026851 Fup 0.615 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026851 Vd NA 0.7641 L/kg 1compartment NA NA Human Human DTXSID3026851 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026851 TK.Half.Life NA 6.49 hours 1compartment NA NA Human Human -DTXSID3026851 Css NA 0.8181 mg/L 3compartmentss NA 50% Human Human -DTXSID3026851 Css NA 5.165 mg/L 3compartmentss NA 95% Human Human -DTXSID3026851 Css NA 0.7227 mg/L PBTK NA 50% Human Human -DTXSID3026851 Css NA 3.43 mg/L PBTK NA 95% Human Human -DTXSID3026851 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026851 Fup NA 0.9962 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026851 Vd NA 0.9928 L/kg 1compartment NA NA Rat Human +DTXSID3026851 TK.Half.Life NA 0.6816 hours 1compartment NA NA Human Human +DTXSID3026851 Css NA 0.02607 mg/L 3compartmentss NA 50% Human Human +DTXSID3026851 Css NA 0.2984 mg/L 3compartmentss NA 95% Human Human +DTXSID3026851 Css NA 0.02069 mg/L PBTK NA 50% Human Human +DTXSID3026851 Css NA 0.2015 mg/L PBTK NA 95% Human Human +DTXSID3026851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026851 Fup 0.615 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026851 Vd NA 0.7596 L/kg 1compartment NA NA Rat Human DTXSID3026851 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026851 TK.Half.Life NA 2.203 hours 1compartment NA NA Rat Human -DTXSID3026851 Css NA 0.2071 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026851 Css NA 1.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026851 Css NA 0.1789 mg/L PBTK NA 50% Rat Human -DTXSID3026851 Css NA 0.7418 mg/L PBTK NA 95% Rat Human -DTXSID3026984 Clint NA 9.143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026984 Fup NA 0.175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3026984 Vd NA 2.149 L/kg 1compartment NA NA Human Human +DTXSID3026851 TK.Half.Life NA 0.3355 hours 1compartment NA NA Rat Human +DTXSID3026851 Css NA 0.0009074 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026851 Css NA 0.01334 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026851 Css NA 0.0007127 mg/L PBTK NA 50% Rat Human +DTXSID3026851 Css NA 0.008838 mg/L PBTK NA 95% Rat Human +DTXSID3026984 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026984 Fup 0.0637 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3026984 Vd NA 1.585 L/kg 1compartment NA NA Human Human DTXSID3026984 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3026984 TK.Half.Life NA 9.616 hours 1compartment NA NA Human Human -DTXSID3026984 Css NA 0.4753 mg/L 3compartmentss NA 50% Human Human -DTXSID3026984 Css NA 2.758 mg/L 3compartmentss NA 95% Human Human -DTXSID3026984 Css NA 0.3398 mg/L PBTK NA 50% Human Human -DTXSID3026984 Css NA 1.857 mg/L PBTK NA 95% Human Human -DTXSID3026984 Clint NA 9.143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026984 Fup NA 0.175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3026984 Vd NA 1.644 L/kg 1compartment NA NA Rat Human +DTXSID3026984 TK.Half.Life NA 6.353 hours 1compartment NA NA Human Human +DTXSID3026984 Css NA 0.5008 mg/L 3compartmentss NA 50% Human Human +DTXSID3026984 Css NA 3.777 mg/L 3compartmentss NA 95% Human Human +DTXSID3026984 Css NA 0.3261 mg/L PBTK NA 50% Human Human +DTXSID3026984 Css NA 2.342 mg/L PBTK NA 95% Human Human +DTXSID3026984 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026984 Fup 0.0637 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3026984 Vd NA 1.197 L/kg 1compartment NA NA Rat Human DTXSID3026984 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3026984 TK.Half.Life NA 3.001 hours 1compartment NA NA Rat Human -DTXSID3026984 Css NA 0.2517 mg/L 3compartmentss NA 50% Rat Human -DTXSID3026984 Css NA 1.055 mg/L 3compartmentss NA 95% Rat Human -DTXSID3026984 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID3026984 Css NA 0.6802 mg/L PBTK NA 95% Rat Human +DTXSID3026984 TK.Half.Life NA 2.398 hours 1compartment NA NA Rat Human +DTXSID3026984 Css NA 0.06468 mg/L 3compartmentss NA 50% Rat Human +DTXSID3026984 Css NA 0.3663 mg/L 3compartmentss NA 95% Rat Human +DTXSID3026984 Css NA 0.04085 mg/L PBTK NA 50% Rat Human +DTXSID3026984 Css NA 0.2234 mg/L PBTK NA 95% Rat Human DTXSID3027037 Clint NA 0.3329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3027037 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3027037 Vd NA 0.8141 L/kg 1compartment NA NA Human Human DTXSID3027037 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3027037 TK.Half.Life NA 3.461 hours 1compartment NA NA Human Human -DTXSID3027037 Css NA 0.5217 mg/L 3compartmentss NA 50% Human Human -DTXSID3027037 Css NA 3.556 mg/L 3compartmentss NA 95% Human Human -DTXSID3027037 Css NA 0.4431 mg/L PBTK NA 50% Human Human -DTXSID3027037 Css NA 2.274 mg/L PBTK NA 95% Human Human +DTXSID3027037 Css NA 0.442 mg/L 3compartmentss NA 50% Human Human +DTXSID3027037 Css NA 2.805 mg/L 3compartmentss NA 95% Human Human +DTXSID3027037 Css NA 0.3748 mg/L PBTK NA 50% Human Human +DTXSID3027037 Css NA 1.826 mg/L PBTK NA 95% Human Human DTXSID3027037 Clint NA 0.3329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3027037 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3027037 Vd NA 0.8469 L/kg 1compartment NA NA Rat Human DTXSID3027037 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3027037 TK.Half.Life NA 1.484 hours 1compartment NA NA Rat Human -DTXSID3027037 Css NA 0.1623 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027037 Css NA 1.054 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027037 Css NA 0.1362 mg/L PBTK NA 50% Rat Human -DTXSID3027037 Css NA 0.6352 mg/L PBTK NA 95% Rat Human -DTXSID3027039 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027039 Fup NA 0.8908 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027039 Vd NA 0.6565 L/kg 1compartment NA NA Human Human +DTXSID3027037 Css NA 0.009781 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027037 Css NA 0.08175 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027037 Css NA 0.008166 mg/L PBTK NA 50% Rat Human +DTXSID3027037 Css NA 0.05384 mg/L PBTK NA 95% Rat Human +DTXSID3027039 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027039 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027039 Vd NA 0.5154 L/kg 1compartment NA NA Human Human DTXSID3027039 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027039 TK.Half.Life NA 4.767 hours 1compartment NA NA Human Human -DTXSID3027039 Css NA 0.961 mg/L 3compartmentss NA 50% Human Human -DTXSID3027039 Css NA 5.039 mg/L 3compartmentss NA 95% Human Human -DTXSID3027039 Css NA 0.7715 mg/L PBTK NA 50% Human Human -DTXSID3027039 Css NA 3.324 mg/L PBTK NA 95% Human Human -DTXSID3027039 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027039 Fup NA 0.8908 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027039 Vd NA 0.7024 L/kg 1compartment NA NA Rat Human +DTXSID3027039 TK.Half.Life NA 6.075 hours 1compartment NA NA Human Human +DTXSID3027039 Css NA 0.7448 mg/L 3compartmentss NA 50% Human Human +DTXSID3027039 Css NA 4.846 mg/L 3compartmentss NA 95% Human Human +DTXSID3027039 Css NA 0.5657 mg/L PBTK NA 50% Human Human +DTXSID3027039 Css NA 2.973 mg/L PBTK NA 95% Human Human +DTXSID3027039 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027039 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027039 Vd NA 0.5455 L/kg 1compartment NA NA Rat Human DTXSID3027039 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027039 TK.Half.Life NA 1.739 hours 1compartment NA NA Rat Human -DTXSID3027039 Css NA 0.2456 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027039 Css NA 1.333 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027039 Css NA 0.1918 mg/L PBTK NA 50% Rat Human -DTXSID3027039 Css NA 0.7971 mg/L PBTK NA 95% Rat Human -DTXSID3027085 Clint NA 140.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027085 Fup NA 0.0571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027085 Vd NA 1.727 L/kg 1compartment NA NA Human Human +DTXSID3027039 TK.Half.Life NA 2.191 hours 1compartment NA NA Rat Human +DTXSID3027039 Css NA 0.00393 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027039 Css NA 0.02748 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027039 Css NA 0.00285 mg/L PBTK NA 50% Rat Human +DTXSID3027039 Css NA 0.01645 mg/L PBTK NA 95% Rat Human +DTXSID3027085 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027085 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027085 Vd NA 2.625 L/kg 1compartment NA NA Human Human DTXSID3027085 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027085 TK.Half.Life NA 2.473 hours 1compartment NA NA Human Human -DTXSID3027085 Css NA 0.09286 mg/L 3compartmentss NA 50% Human Human -DTXSID3027085 Css NA 0.718 mg/L 3compartmentss NA 95% Human Human -DTXSID3027085 Css NA 0.06058 mg/L PBTK NA 50% Human Human -DTXSID3027085 Css NA 0.4434 mg/L PBTK NA 95% Human Human -DTXSID3027085 Clint NA 140.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027085 Fup NA 0.0571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027085 Vd NA 1.298 L/kg 1compartment NA NA Rat Human +DTXSID3027085 TK.Half.Life NA 7.911 hours 1compartment NA NA Human Human +DTXSID3027085 Css NA 0.266 mg/L 3compartmentss NA 50% Human Human +DTXSID3027085 Css NA 1.656 mg/L 3compartmentss NA 95% Human Human +DTXSID3027085 Css NA 0.1934 mg/L PBTK NA 50% Human Human +DTXSID3027085 Css NA 1.14 mg/L PBTK NA 95% Human Human +DTXSID3027085 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027085 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027085 Vd NA 1.994 L/kg 1compartment NA NA Rat Human DTXSID3027085 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027085 TK.Half.Life NA 0.8576 hours 1compartment NA NA Rat Human -DTXSID3027085 Css NA 0.0537 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027085 Css NA 0.3464 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027085 Css NA 0.03283 mg/L PBTK NA 50% Rat Human -DTXSID3027085 Css NA 0.201 mg/L PBTK NA 95% Rat Human -DTXSID3027247 Clint NA 0.05301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027247 Fup NA 0.3588 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027247 Vd NA 1.916 L/kg 1compartment NA NA Human Human -DTXSID3027247 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID3027247 TK.Half.Life NA 49.06 hours 1compartment NA NA Human Human -DTXSID3027247 Css NA 2.666 mg/L 3compartmentss NA 50% Human Human -DTXSID3027247 Css NA 9.685 mg/L 3compartmentss NA 95% Human Human -DTXSID3027247 Css NA 2.106 mg/L PBTK NA 50% Human Human -DTXSID3027247 Css NA 6.511 mg/L PBTK NA 95% Human Human -DTXSID3027247 Clint NA 0.05301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027247 Fup NA 0.3588 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027247 Vd NA 1.527 L/kg 1compartment NA NA Rat Human -DTXSID3027247 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3027247 TK.Half.Life NA 10.15 hours 1compartment NA NA Rat Human -DTXSID3027247 Css NA 0.7695 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027247 Css NA 2.342 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027247 Css NA 0.5835 mg/L PBTK NA 50% Rat Human -DTXSID3027247 Css NA 1.467 mg/L PBTK NA 95% Rat Human -DTXSID3027249 Clint NA 2.882 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027249 Fup NA 0.1738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027249 Vd NA 0.4361 L/kg 1compartment NA NA Human Human +DTXSID3027085 TK.Half.Life NA 2.03 hours 1compartment NA NA Rat Human +DTXSID3027085 Css NA 0.0336 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027085 Css NA 0.1669 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027085 Css NA 0.02416 mg/L PBTK NA 50% Rat Human +DTXSID3027085 Css NA 0.1172 mg/L PBTK NA 95% Rat Human +DTXSID3027247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027247 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027247 Vd NA 1.54 L/kg 1compartment NA NA Human Human +DTXSID3027247 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3027247 TK.Half.Life NA 2.518 hours 1compartment NA NA Human Human +DTXSID3027247 Css NA 0.1064 mg/L 3compartmentss NA 50% Human Human +DTXSID3027247 Css NA 0.7362 mg/L 3compartmentss NA 95% Human Human +DTXSID3027247 Css NA 0.07758 mg/L PBTK NA 50% Human Human +DTXSID3027247 Css NA 0.4997 mg/L PBTK NA 95% Human Human +DTXSID3027247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027247 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027247 Vd NA 1.223 L/kg 1compartment NA NA Rat Human +DTXSID3027247 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3027247 TK.Half.Life NA 0.9826 hours 1compartment NA NA Rat Human +DTXSID3027247 Css NA 0.01319 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027247 Css NA 0.07216 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027247 Css NA 0.009593 mg/L PBTK NA 50% Rat Human +DTXSID3027247 Css NA 0.04952 mg/L PBTK NA 95% Rat Human +DTXSID3027249 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027249 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027249 Vd NA 0.4338 L/kg 1compartment NA NA Human Human DTXSID3027249 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027249 TK.Half.Life NA 3.051 hours 1compartment NA NA Human Human -DTXSID3027249 Css NA 0.8173 mg/L 3compartmentss NA 50% Human Human -DTXSID3027249 Css NA 4.109 mg/L 3compartmentss NA 95% Human Human -DTXSID3027249 Css NA 0.5536 mg/L PBTK NA 50% Human Human -DTXSID3027249 Css NA 2.592 mg/L PBTK NA 95% Human Human -DTXSID3027249 Clint NA 2.882 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027249 Fup NA 0.1738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027249 Vd NA 0.4343 L/kg 1compartment NA NA Rat Human +DTXSID3027249 TK.Half.Life NA 0.7796 hours 1compartment NA NA Human Human +DTXSID3027249 Css NA 0.1264 mg/L 3compartmentss NA 50% Human Human +DTXSID3027249 Css NA 0.8746 mg/L 3compartmentss NA 95% Human Human +DTXSID3027249 Css NA 0.08514 mg/L PBTK NA 50% Human Human +DTXSID3027249 Css NA 0.5668 mg/L PBTK NA 95% Human Human +DTXSID3027249 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027249 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027249 Vd NA 0.4321 L/kg 1compartment NA NA Rat Human DTXSID3027249 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027249 TK.Half.Life NA 1.735 hours 1compartment NA NA Rat Human -DTXSID3027249 Css NA 0.3854 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027249 Css NA 1.443 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027249 Css NA 0.2478 mg/L PBTK NA 50% Rat Human -DTXSID3027249 Css NA 0.8478 mg/L PBTK NA 95% Rat Human -DTXSID3027297 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027297 Fup NA 0.1479 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027297 Vd NA 0.5676 L/kg 1compartment NA NA Human Human +DTXSID3027249 TK.Half.Life NA 0.4387 hours 1compartment NA NA Rat Human +DTXSID3027249 Css NA 0.01599 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027249 Css NA 0.08557 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027249 Css NA 0.01062 mg/L PBTK NA 50% Rat Human +DTXSID3027249 Css NA 0.05414 mg/L PBTK NA 95% Rat Human +DTXSID3027297 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027297 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027297 Vd NA 0.5045 L/kg 1compartment NA NA Human Human DTXSID3027297 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3027297 TK.Half.Life NA 24.93 hours 1compartment NA NA Human Human -DTXSID3027297 Css NA 5.68 mg/L 3compartmentss NA 50% Human Human -DTXSID3027297 Css NA 27.64 mg/L 3compartmentss NA 95% Human Human -DTXSID3027297 Css NA 4.044 mg/L PBTK NA 50% Human Human -DTXSID3027297 Css NA 17.08 mg/L PBTK NA 95% Human Human -DTXSID3027297 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027297 Fup NA 0.1479 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027297 Vd NA 0.5517 L/kg 1compartment NA NA Rat Human +DTXSID3027297 TK.Half.Life NA 23.87 hours 1compartment NA NA Human Human +DTXSID3027297 Css NA 6.228 mg/L 3compartmentss NA 50% Human Human +DTXSID3027297 Css NA 30.67 mg/L 3compartmentss NA 95% Human Human +DTXSID3027297 Css NA 4.302 mg/L PBTK NA 50% Human Human +DTXSID3027297 Css NA 18.91 mg/L PBTK NA 95% Human Human +DTXSID3027297 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027297 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027297 Vd NA 0.4918 L/kg 1compartment NA NA Rat Human DTXSID3027297 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027297 TK.Half.Life NA 8.229 hours 1compartment NA NA Rat Human -DTXSID3027297 Css NA 1.565 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027297 Css NA 6.634 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027297 Css NA 1.059 mg/L PBTK NA 50% Rat Human -DTXSID3027297 Css NA 3.833 mg/L PBTK NA 95% Rat Human +DTXSID3027297 TK.Half.Life NA 7.92 hours 1compartment NA NA Rat Human +DTXSID3027297 Css NA 0.4009 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027297 Css NA 1.667 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027297 Css NA 0.2708 mg/L PBTK NA 50% Rat Human +DTXSID3027297 Css NA 0.9858 mg/L PBTK NA 95% Rat Human DTXSID3027320 Clint 48.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3027320 Fup 0.17 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3027320 Vd NA 0.5805 L/kg 1compartment NA NA Human Human +DTXSID3027320 Vd NA 0.7192 L/kg 1compartment NA NA Human Human DTXSID3027320 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027320 TK.Half.Life NA 0.7542 hours 1compartment NA NA Human Human -DTXSID3027320 Css NA 0.05662 mg/L 3compartmentss NA 50% Human Human -DTXSID3027320 Css NA 0.3627 mg/L 3compartmentss NA 95% Human Human -DTXSID3027320 Css NA 0.0376 mg/L PBTK NA 50% Human Human -DTXSID3027320 Css NA 0.2336 mg/L PBTK NA 95% Human Human +DTXSID3027320 TK.Half.Life NA 0.9308 hours 1compartment NA NA Human Human +DTXSID3027320 Css NA 0.05295 mg/L 3compartmentss NA 50% Human Human +DTXSID3027320 Css NA 0.3583 mg/L 3compartmentss NA 95% Human Human +DTXSID3027320 Css NA 0.03545 mg/L PBTK NA 50% Human Human +DTXSID3027320 Css NA 0.2308 mg/L PBTK NA 95% Human Human DTXSID3027320 Clint 48.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3027320 Fup 0.17 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3027320 Vd NA 0.5005 L/kg 1compartment NA NA Rat Human +DTXSID3027320 Vd NA 0.5981 L/kg 1compartment NA NA Rat Human DTXSID3027320 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027320 TK.Half.Life NA 0.3358 hours 1compartment NA NA Rat Human -DTXSID3027320 Css NA 0.0315 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027320 Css NA 0.1577 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027320 Css NA 0.01983 mg/L PBTK NA 50% Rat Human -DTXSID3027320 Css NA 0.09671 mg/L PBTK NA 95% Rat Human +DTXSID3027320 TK.Half.Life NA 0.397 hours 1compartment NA NA Rat Human +DTXSID3027320 Css NA 0.006807 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027320 Css NA 0.03626 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027320 Css NA 0.004518 mg/L PBTK NA 50% Rat Human +DTXSID3027320 Css NA 0.02362 mg/L PBTK NA 95% Rat Human DTXSID3027328 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3027328 Fup NA 0.5822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027328 Vd NA 0.3752 L/kg 1compartment NA NA Human Human +DTXSID3027328 Vd NA 0.3375 L/kg 1compartment NA NA Human Human DTXSID3027328 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027328 TK.Half.Life NA 4.168 hours 1compartment NA NA Human Human -DTXSID3027328 Css NA 1.442 mg/L 3compartmentss NA 50% Human Human -DTXSID3027328 Css NA 9.153 mg/L 3compartmentss NA 95% Human Human -DTXSID3027328 Css NA 1.01 mg/L PBTK NA 50% Human Human -DTXSID3027328 Css NA 5.6 mg/L PBTK NA 95% Human Human +DTXSID3027328 TK.Half.Life NA 3.751 hours 1compartment NA NA Human Human +DTXSID3027328 Css NA 1.228 mg/L 3compartmentss NA 50% Human Human +DTXSID3027328 Css NA 8.069 mg/L 3compartmentss NA 95% Human Human +DTXSID3027328 Css NA 0.8466 mg/L PBTK NA 50% Human Human +DTXSID3027328 Css NA 4.896 mg/L PBTK NA 95% Human Human DTXSID3027328 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3027328 Fup NA 0.5822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027328 Vd NA 0.393 L/kg 1compartment NA NA Rat Human +DTXSID3027328 Vd NA 0.362 L/kg 1compartment NA NA Rat Human DTXSID3027328 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027328 TK.Half.Life NA 1.489 hours 1compartment NA NA Rat Human -DTXSID3027328 Css NA 0.3807 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027328 Css NA 2.194 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027328 Css NA 0.2544 mg/L PBTK NA 50% Rat Human -DTXSID3027328 Css NA 1.242 mg/L PBTK NA 95% Rat Human +DTXSID3027328 TK.Half.Life NA 1.371 hours 1compartment NA NA Rat Human +DTXSID3027328 Css NA 0.02379 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027328 Css NA 0.1936 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027328 Css NA 0.0157 mg/L PBTK NA 50% Rat Human +DTXSID3027328 Css NA 0.1134 mg/L PBTK NA 95% Rat Human DTXSID3027401 Clint NA 1.021 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3027401 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027401 Vd NA 1.233 L/kg 1compartment NA NA Human Human +DTXSID3027401 Vd NA 1.31 L/kg 1compartment NA NA Human Human DTXSID3027401 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027401 TK.Half.Life NA 3.357 hours 1compartment NA NA Human Human -DTXSID3027401 Css NA 0.2886 mg/L 3compartmentss NA 50% Human Human -DTXSID3027401 Css NA 2.011 mg/L 3compartmentss NA 95% Human Human -DTXSID3027401 Css NA 0.2628 mg/L PBTK NA 50% Human Human -DTXSID3027401 Css NA 1.397 mg/L PBTK NA 95% Human Human +DTXSID3027401 TK.Half.Life NA 3.614 hours 1compartment NA NA Human Human +DTXSID3027401 Css NA 0.2396 mg/L 3compartmentss NA 50% Human Human +DTXSID3027401 Css NA 1.716 mg/L 3compartmentss NA 95% Human Human +DTXSID3027401 Css NA 0.2203 mg/L PBTK NA 50% Human Human +DTXSID3027401 Css NA 1.19 mg/L PBTK NA 95% Human Human DTXSID3027401 Clint NA 1.021 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3027401 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027401 Vd NA 1.167 L/kg 1compartment NA NA Rat Human +DTXSID3027401 Vd NA 1.224 L/kg 1compartment NA NA Rat Human DTXSID3027401 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027401 TK.Half.Life NA 1.479 hours 1compartment NA NA Rat Human -DTXSID3027401 Css NA 0.1073 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027401 Css NA 0.7139 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027401 Css NA 0.09778 mg/L PBTK NA 50% Rat Human -DTXSID3027401 Css NA 0.443 mg/L PBTK NA 95% Rat Human +DTXSID3027401 TK.Half.Life NA 1.554 hours 1compartment NA NA Rat Human +DTXSID3027401 Css NA 0.006193 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027401 Css NA 0.05896 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027401 Css NA 0.0056 mg/L PBTK NA 50% Rat Human +DTXSID3027401 Css NA 0.04133 mg/L PBTK NA 95% Rat Human DTXSID3027403 Clint 782 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3027403 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3027403 Vd NA 2.972 L/kg 1compartment NA NA Human Human DTXSID3027403 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3027403 TK.Half.Life NA 4.104 hours 1compartment NA NA Human Human -DTXSID3027403 Css NA 0.07514 mg/L 3compartmentss NA 50% Human Human -DTXSID3027403 Css NA 0.5061 mg/L 3compartmentss NA 95% Human Human -DTXSID3027403 Css NA 0.05147 mg/L PBTK NA 50% Human Human -DTXSID3027403 Css NA 0.3344 mg/L PBTK NA 95% Human Human +DTXSID3027403 Css NA 0.05825 mg/L 3compartmentss NA 50% Human Human +DTXSID3027403 Css NA 0.4315 mg/L 3compartmentss NA 95% Human Human +DTXSID3027403 Css NA 0.03967 mg/L PBTK NA 50% Human Human +DTXSID3027403 Css NA 0.2825 mg/L PBTK NA 95% Human Human DTXSID3027403 Clint 782 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3027403 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3027403 Vd NA 2.225 L/kg 1compartment NA NA Rat Human DTXSID3027403 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3027403 TK.Half.Life NA 1.066 hours 1compartment NA NA Rat Human -DTXSID3027403 Css NA 0.04209 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027403 Css NA 0.2506 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027403 Css NA 0.02744 mg/L PBTK NA 50% Rat Human -DTXSID3027403 Css NA 0.1568 mg/L PBTK NA 95% Rat Human -DTXSID3027407 Clint NA 0.0821 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027407 Fup NA 0.6479 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027407 Vd NA 1.738 L/kg 1compartment NA NA Human Human -DTXSID3027407 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3027407 TK.Half.Life NA 19.72 hours 1compartment NA NA Human Human -DTXSID3027407 Css NA 1.093 mg/L 3compartmentss NA 50% Human Human -DTXSID3027407 Css NA 7.079 mg/L 3compartmentss NA 95% Human Human -DTXSID3027407 Css NA 0.9732 mg/L PBTK NA 50% Human Human -DTXSID3027407 Css NA 4.67 mg/L PBTK NA 95% Human Human -DTXSID3027407 Clint NA 0.0821 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027407 Fup NA 0.6479 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027407 Vd NA 1.47 L/kg 1compartment NA NA Rat Human +DTXSID3027403 Css NA 0.002203 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027403 Css NA 0.01822 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027403 Css NA 0.00145 mg/L PBTK NA 50% Rat Human +DTXSID3027403 Css NA 0.01143 mg/L PBTK NA 95% Rat Human +DTXSID3027407 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027407 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027407 Vd NA 1.436 L/kg 1compartment NA NA Human Human +DTXSID3027407 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3027407 TK.Half.Life NA 25.11 hours 1compartment NA NA Human Human +DTXSID3027407 Css NA 1.509 mg/L 3compartmentss NA 50% Human Human +DTXSID3027407 Css NA 6.704 mg/L 3compartmentss NA 95% Human Human +DTXSID3027407 Css NA 1.236 mg/L PBTK NA 50% Human Human +DTXSID3027407 Css NA 4.498 mg/L PBTK NA 95% Human Human +DTXSID3027407 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027407 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027407 Vd NA 1.208 L/kg 1compartment NA NA Rat Human DTXSID3027407 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027407 TK.Half.Life NA 5.008 hours 1compartment NA NA Rat Human -DTXSID3027407 Css NA 0.3143 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027407 Css NA 1.912 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027407 Css NA 0.2722 mg/L PBTK NA 50% Rat Human -DTXSID3027407 Css NA 1.177 mg/L PBTK NA 95% Rat Human -DTXSID3027530 Clint NA 0.9813 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027530 Fup NA 0.0942 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027530 Vd NA 3.038 L/kg 1compartment NA NA Human Human -DTXSID3027530 Days.Css NA 149 Days PBTK NA NA Human Human -DTXSID3027530 TK.Half.Life NA 618.9 hours 1compartment NA NA Human Human -DTXSID3027530 Css NA 25.34 mg/L 3compartmentss NA 50% Human Human -DTXSID3027530 Css NA 103.6 mg/L 3compartmentss NA 95% Human Human -DTXSID3027530 Css NA 17.6 mg/L PBTK NA 50% Human Human -DTXSID3027530 Css NA 68.9 mg/L PBTK NA 95% Human Human -DTXSID3027530 Clint NA 0.9813 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027530 Fup NA 0.0942 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027530 Vd NA 2.281 L/kg 1compartment NA NA Rat Human -DTXSID3027530 Days.Css NA 68 Days PBTK NA NA Rat Human -DTXSID3027530 TK.Half.Life NA 78.23 hours 1compartment NA NA Rat Human -DTXSID3027530 Css NA 12.05 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027530 Css NA 33.17 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027530 Css NA 8.013 mg/L PBTK NA 50% Rat Human -DTXSID3027530 Css NA 20.8 mg/L PBTK NA 95% Rat Human -DTXSID3027534 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027534 Fup NA 0.8599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027534 Vd NA 2.677 L/kg 1compartment NA NA Human Human -DTXSID3027534 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3027534 TK.Half.Life NA 20.15 hours 1compartment NA NA Human Human -DTXSID3027534 Css NA 0.7031 mg/L 3compartmentss NA 50% Human Human -DTXSID3027534 Css NA 5.091 mg/L 3compartmentss NA 95% Human Human -DTXSID3027534 Css NA 0.7862 mg/L PBTK NA 50% Human Human -DTXSID3027534 Css NA 3.678 mg/L PBTK NA 95% Human Human -DTXSID3027534 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027534 Fup NA 0.8599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027534 Vd NA 2.723 L/kg 1compartment NA NA Rat Human +DTXSID3027407 TK.Half.Life NA 6.261 hours 1compartment NA NA Rat Human +DTXSID3027407 Css NA 0.02741 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027407 Css NA 0.1784 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027407 Css NA 0.02188 mg/L PBTK NA 50% Rat Human +DTXSID3027407 Css NA 0.1221 mg/L PBTK NA 95% Rat Human +DTXSID3027530 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027530 Fup 0.0626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027530 Vd NA 2.979 L/kg 1compartment NA NA Human Human +DTXSID3027530 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3027530 TK.Half.Life NA 35.47 hours 1compartment NA NA Human Human +DTXSID3027530 Css NA 1.397 mg/L 3compartmentss NA 50% Human Human +DTXSID3027530 Css NA 9.028 mg/L 3compartmentss NA 95% Human Human +DTXSID3027530 Css NA 0.9672 mg/L PBTK NA 50% Human Human +DTXSID3027530 Css NA 6.106 mg/L PBTK NA 95% Human Human +DTXSID3027530 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027530 Fup 0.0626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027530 Vd NA 2.235 L/kg 1compartment NA NA Rat Human +DTXSID3027530 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3027530 TK.Half.Life NA 5.986 hours 1compartment NA NA Rat Human +DTXSID3027530 Css NA 0.1804 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027530 Css NA 0.9723 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027530 Css NA 0.1236 mg/L PBTK NA 50% Rat Human +DTXSID3027530 Css NA 0.6415 mg/L PBTK NA 95% Rat Human +DTXSID3027534 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027534 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027534 Vd NA 1.297 L/kg 1compartment NA NA Human Human +DTXSID3027534 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3027534 TK.Half.Life NA 13.28 hours 1compartment NA NA Human Human +DTXSID3027534 Css NA 0.8811 mg/L 3compartmentss NA 50% Human Human +DTXSID3027534 Css NA 6.677 mg/L 3compartmentss NA 95% Human Human +DTXSID3027534 Css NA 0.7928 mg/L PBTK NA 50% Human Human +DTXSID3027534 Css NA 4.31 mg/L PBTK NA 95% Human Human +DTXSID3027534 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027534 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027534 Vd NA 1.328 L/kg 1compartment NA NA Rat Human DTXSID3027534 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027534 TK.Half.Life NA 6.982 hours 1compartment NA NA Rat Human -DTXSID3027534 Css NA 0.1738 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027534 Css NA 1.27 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027534 Css NA 0.1942 mg/L PBTK NA 50% Rat Human -DTXSID3027534 Css NA 0.853 mg/L PBTK NA 95% Rat Human -DTXSID3027536 Clint NA 3.061 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027536 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027536 Vd NA 1172 L/kg 1compartment NA NA Human Human -DTXSID3027536 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID3027536 TK.Half.Life NA 243300 hours 1compartment NA NA Human Human -DTXSID3027536 Css NA 0.08918 mg/L 3compartmentss NA 50% Human Human -DTXSID3027536 Css NA 0.5549 mg/L 3compartmentss NA 95% Human Human -DTXSID3027536 Css NA 17.2 mg/L PBTK NA 50% Human Human -DTXSID3027536 Css NA 96.35 mg/L PBTK NA 95% Human Human -DTXSID3027536 Clint NA 3.061 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027536 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027536 Vd NA 1076 L/kg 1compartment NA NA Rat Human -DTXSID3027536 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID3027536 TK.Half.Life NA 38320 hours 1compartment NA NA Rat Human -DTXSID3027536 Css NA 0.04586 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027536 Css NA 0.1858 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027536 Css NA 9.336 mg/L PBTK NA 50% Rat Human -DTXSID3027536 Css NA 37.1 mg/L PBTK NA 95% Rat Human -DTXSID3027580 Clint NA 7.183 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027580 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027580 Vd NA 146.8 L/kg 1compartment NA NA Human Human -DTXSID3027580 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID3027580 TK.Half.Life NA 13010 hours 1compartment NA NA Human Human -DTXSID3027580 Css NA 0.3907 mg/L 3compartmentss NA 50% Human Human -DTXSID3027580 Css NA 2.39 mg/L 3compartmentss NA 95% Human Human -DTXSID3027580 Css NA 7.33 mg/L PBTK NA 50% Human Human -DTXSID3027580 Css NA 42.3 mg/L PBTK NA 95% Human Human -DTXSID3027580 Clint NA 7.183 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027580 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027580 Vd NA 128.5 L/kg 1compartment NA NA Rat Human -DTXSID3027580 Days.Css NA 2207 Days PBTK NA NA Rat Human -DTXSID3027580 TK.Half.Life NA 1949 hours 1compartment NA NA Rat Human -DTXSID3027580 Css NA 0.1971 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027580 Css NA 0.8265 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027580 Css NA 3.956 mg/L PBTK NA 50% Rat Human -DTXSID3027580 Css NA 15.71 mg/L PBTK NA 95% Rat Human -DTXSID3027584 Clint NA 24.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027584 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027584 Vd NA 2.377 L/kg 1compartment NA NA Human Human +DTXSID3027534 TK.Half.Life NA 4.633 hours 1compartment NA NA Rat Human +DTXSID3027534 Css NA 0.01699 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027534 Css NA 0.1475 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027534 Css NA 0.01478 mg/L PBTK NA 50% Rat Human +DTXSID3027534 Css NA 0.0983 mg/L PBTK NA 95% Rat Human +DTXSID3027584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027584 Fup 0.0256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027584 Vd NA 2.731 L/kg 1compartment NA NA Human Human DTXSID3027584 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027584 TK.Half.Life NA 11.8 hours 1compartment NA NA Human Human -DTXSID3027584 Css NA 0.6486 mg/L 3compartmentss NA 50% Human Human -DTXSID3027584 Css NA 5.512 mg/L 3compartmentss NA 95% Human Human -DTXSID3027584 Css NA 0.4382 mg/L PBTK NA 50% Human Human -DTXSID3027584 Css NA 3.475 mg/L PBTK NA 95% Human Human -DTXSID3027584 Clint NA 24.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027584 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027584 Vd NA 1.87 L/kg 1compartment NA NA Rat Human +DTXSID3027584 TK.Half.Life NA 12.45 hours 1compartment NA NA Human Human +DTXSID3027584 Css NA 0.539 mg/L 3compartmentss NA 50% Human Human +DTXSID3027584 Css NA 4.224 mg/L 3compartmentss NA 95% Human Human +DTXSID3027584 Css NA 0.3762 mg/L PBTK NA 50% Human Human +DTXSID3027584 Css NA 2.788 mg/L PBTK NA 95% Human Human +DTXSID3027584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027584 Fup 0.0256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027584 Vd NA 2.159 L/kg 1compartment NA NA Rat Human DTXSID3027584 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027584 TK.Half.Life NA 3.923 hours 1compartment NA NA Rat Human -DTXSID3027584 Css NA 0.3644 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027584 Css NA 2.592 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027584 Css NA 0.2338 mg/L PBTK NA 50% Rat Human -DTXSID3027584 Css NA 1.554 mg/L PBTK NA 95% Rat Human -DTXSID3027588 Clint NA 1.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027588 Fup NA 0.2058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027588 Vd NA 2.721 L/kg 1compartment NA NA Human Human -DTXSID3027588 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID3027588 TK.Half.Life NA 95.45 hours 1compartment NA NA Human Human -DTXSID3027588 Css NA 4.044 mg/L 3compartmentss NA 50% Human Human -DTXSID3027588 Css NA 14.68 mg/L 3compartmentss NA 95% Human Human -DTXSID3027588 Css NA 2.929 mg/L PBTK NA 50% Human Human -DTXSID3027588 Css NA 9.909 mg/L PBTK NA 95% Human Human -DTXSID3027588 Clint NA 1.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027588 Fup NA 0.2058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027588 Vd NA 2.067 L/kg 1compartment NA NA Rat Human -DTXSID3027588 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID3027588 TK.Half.Life NA 16.77 hours 1compartment NA NA Rat Human -DTXSID3027588 Css NA 1.753 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027588 Css NA 4.578 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027588 Css NA 1.226 mg/L PBTK NA 50% Rat Human -DTXSID3027588 Css NA 2.881 mg/L PBTK NA 95% Rat Human -DTXSID3027615 Clint NA 134.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027615 Fup NA 0.0531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027615 Vd NA 1.396 L/kg 1compartment NA NA Human Human +DTXSID3027584 TK.Half.Life NA 3.625 hours 1compartment NA NA Rat Human +DTXSID3027584 Css NA 0.0693 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027584 Css NA 0.4534 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027584 Css NA 0.04823 mg/L PBTK NA 50% Rat Human +DTXSID3027584 Css NA 0.2991 mg/L PBTK NA 95% Rat Human +DTXSID3027588 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027588 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027588 Vd NA 2.519 L/kg 1compartment NA NA Human Human +DTXSID3027588 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3027588 TK.Half.Life NA 9.075 hours 1compartment NA NA Human Human +DTXSID3027588 Css NA 0.3674 mg/L 3compartmentss NA 50% Human Human +DTXSID3027588 Css NA 2.604 mg/L 3compartmentss NA 95% Human Human +DTXSID3027588 Css NA 0.2565 mg/L PBTK NA 50% Human Human +DTXSID3027588 Css NA 1.708 mg/L PBTK NA 95% Human Human +DTXSID3027588 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027588 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027588 Vd NA 1.905 L/kg 1compartment NA NA Rat Human +DTXSID3027588 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3027588 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human +DTXSID3027588 Css NA 0.04764 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027588 Css NA 0.2467 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027588 Css NA 0.03303 mg/L PBTK NA 50% Rat Human +DTXSID3027588 Css NA 0.1637 mg/L PBTK NA 95% Rat Human +DTXSID3027615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027615 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027615 Vd NA 1.868 L/kg 1compartment NA NA Human Human DTXSID3027615 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027615 TK.Half.Life NA 2.037 hours 1compartment NA NA Human Human -DTXSID3027615 Css NA 0.0998 mg/L 3compartmentss NA 50% Human Human -DTXSID3027615 Css NA 0.826 mg/L 3compartmentss NA 95% Human Human -DTXSID3027615 Css NA 0.0637 mg/L PBTK NA 50% Human Human -DTXSID3027615 Css NA 0.5107 mg/L PBTK NA 95% Human Human -DTXSID3027615 Clint NA 134.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027615 Fup NA 0.0531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027615 Vd NA 1.053 L/kg 1compartment NA NA Rat Human +DTXSID3027615 TK.Half.Life NA 5.728 hours 1compartment NA NA Human Human +DTXSID3027615 Css NA 0.3302 mg/L 3compartmentss NA 50% Human Human +DTXSID3027615 Css NA 2.38 mg/L 3compartmentss NA 95% Human Human +DTXSID3027615 Css NA 0.2222 mg/L PBTK NA 50% Human Human +DTXSID3027615 Css NA 1.52 mg/L PBTK NA 95% Human Human +DTXSID3027615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027615 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027615 Vd NA 1.419 L/kg 1compartment NA NA Rat Human DTXSID3027615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027615 TK.Half.Life NA 0.7463 hours 1compartment NA NA Rat Human -DTXSID3027615 Css NA 0.0566 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027615 Css NA 0.3912 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027615 Css NA 0.03387 mg/L PBTK NA 50% Rat Human -DTXSID3027615 Css NA 0.2238 mg/L PBTK NA 95% Rat Human -DTXSID3027617 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027617 Fup NA 0.6135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027617 Vd NA 0.6445 L/kg 1compartment NA NA Human Human -DTXSID3027617 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027617 TK.Half.Life NA 6.796 hours 1compartment NA NA Human Human -DTXSID3027617 Css NA 1.199 mg/L 3compartmentss NA 50% Human Human -DTXSID3027617 Css NA 8.228 mg/L 3compartmentss NA 95% Human Human -DTXSID3027617 Css NA 0.9642 mg/L PBTK NA 50% Human Human -DTXSID3027617 Css NA 5.206 mg/L PBTK NA 95% Human Human -DTXSID3027617 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027617 Fup NA 0.6135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027617 Vd NA 0.6661 L/kg 1compartment NA NA Rat Human -DTXSID3027617 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027617 TK.Half.Life NA 2.393 hours 1compartment NA NA Rat Human -DTXSID3027617 Css NA 0.3197 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027617 Css NA 1.993 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027617 Css NA 0.2452 mg/L PBTK NA 50% Rat Human -DTXSID3027617 Css NA 1.171 mg/L PBTK NA 95% Rat Human -DTXSID3027740 Clint NA 19.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027740 Fup NA 0.358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027740 Vd NA 0.5524 L/kg 1compartment NA NA Human Human -DTXSID3027740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027740 TK.Half.Life NA 0.6776 hours 1compartment NA NA Human Human -DTXSID3027740 Css NA 0.06482 mg/L 3compartmentss NA 50% Human Human -DTXSID3027740 Css NA 0.4694 mg/L 3compartmentss NA 95% Human Human -DTXSID3027740 Css NA 0.04788 mg/L PBTK NA 50% Human Human -DTXSID3027740 Css NA 0.3168 mg/L PBTK NA 95% Human Human -DTXSID3027740 Clint NA 19.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027740 Fup NA 0.358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027740 Vd NA 0.5607 L/kg 1compartment NA NA Rat Human -DTXSID3027740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027740 TK.Half.Life NA 0.3629 hours 1compartment NA NA Rat Human -DTXSID3027740 Css NA 0.03421 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027740 Css NA 0.2032 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027740 Css NA 0.02426 mg/L PBTK NA 50% Rat Human -DTXSID3027740 Css NA 0.1279 mg/L PBTK NA 95% Rat Human -DTXSID3027790 Clint NA 17.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027790 Fup NA 0.4218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027790 Vd NA 0.8637 L/kg 1compartment NA NA Human Human +DTXSID3027615 TK.Half.Life NA 1.994 hours 1compartment NA NA Rat Human +DTXSID3027615 Css NA 0.04234 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027615 Css NA 0.2411 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027615 Css NA 0.02817 mg/L PBTK NA 50% Rat Human +DTXSID3027615 Css NA 0.1515 mg/L PBTK NA 95% Rat Human +DTXSID3027617 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027617 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027617 Vd NA 2.391 L/kg 1compartment NA NA Human Human +DTXSID3027617 Days.Css NA 29 Days PBTK NA NA Human Human +DTXSID3027617 TK.Half.Life NA 147.9 hours 1compartment NA NA Human Human +DTXSID3027617 Css NA 6.566 mg/L 3compartmentss NA 50% Human Human +DTXSID3027617 Css NA 20.12 mg/L 3compartmentss NA 95% Human Human +DTXSID3027617 Css NA 4.91 mg/L PBTK NA 50% Human Human +DTXSID3027617 Css NA 13.6 mg/L PBTK NA 95% Human Human +DTXSID3027617 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027617 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027617 Vd NA 1.838 L/kg 1compartment NA NA Rat Human +DTXSID3027617 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID3027617 TK.Half.Life NA 21.24 hours 1compartment NA NA Rat Human +DTXSID3027617 Css NA 0.416 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027617 Css NA 1.044 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027617 Css NA 0.3082 mg/L PBTK NA 50% Rat Human +DTXSID3027617 Css NA 0.6716 mg/L PBTK NA 95% Rat Human +DTXSID3027790 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027790 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027790 Vd NA 0.5989 L/kg 1compartment NA NA Human Human DTXSID3027790 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027790 TK.Half.Life NA 1.016 hours 1compartment NA NA Human Human -DTXSID3027790 Css NA 0.06199 mg/L 3compartmentss NA 50% Human Human -DTXSID3027790 Css NA 0.4458 mg/L 3compartmentss NA 95% Human Human -DTXSID3027790 Css NA 0.04782 mg/L PBTK NA 50% Human Human -DTXSID3027790 Css NA 0.3094 mg/L PBTK NA 95% Human Human -DTXSID3027790 Clint NA 17.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027790 Fup NA 0.4218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027790 Vd NA 0.7951 L/kg 1compartment NA NA Rat Human +DTXSID3027790 TK.Half.Life NA 1.668 hours 1compartment NA NA Human Human +DTXSID3027790 Css NA 0.2561 mg/L 3compartmentss NA 50% Human Human +DTXSID3027790 Css NA 1.558 mg/L 3compartmentss NA 95% Human Human +DTXSID3027790 Css NA 0.1781 mg/L PBTK NA 50% Human Human +DTXSID3027790 Css NA 1.004 mg/L PBTK NA 95% Human Human +DTXSID3027790 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027790 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027790 Vd NA 0.563 L/kg 1compartment NA NA Rat Human DTXSID3027790 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027790 TK.Half.Life NA 0.4857 hours 1compartment NA NA Rat Human -DTXSID3027790 Css NA 0.03213 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027790 Css NA 0.1926 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027790 Css NA 0.024 mg/L PBTK NA 50% Rat Human -DTXSID3027790 Css NA 0.1271 mg/L PBTK NA 95% Rat Human -DTXSID3027792 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027792 Fup NA 0.6707 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027792 Vd NA 1.165 L/kg 1compartment NA NA Human Human +DTXSID3027790 TK.Half.Life NA 0.8973 hours 1compartment NA NA Rat Human +DTXSID3027790 Css NA 0.03024 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027790 Css NA 0.135 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027790 Css NA 0.02099 mg/L PBTK NA 50% Rat Human +DTXSID3027790 Css NA 0.08401 mg/L PBTK NA 95% Rat Human +DTXSID3027792 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027792 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027792 Vd NA 0.9431 L/kg 1compartment NA NA Human Human DTXSID3027792 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3027792 TK.Half.Life NA 12 hours 1compartment NA NA Human Human -DTXSID3027792 Css NA 1.086 mg/L 3compartmentss NA 50% Human Human -DTXSID3027792 Css NA 7.182 mg/L 3compartmentss NA 95% Human Human -DTXSID3027792 Css NA 0.9448 mg/L PBTK NA 50% Human Human -DTXSID3027792 Css NA 4.68 mg/L PBTK NA 95% Human Human -DTXSID3027792 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027792 Fup NA 0.6707 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027792 Vd NA 1.071 L/kg 1compartment NA NA Rat Human +DTXSID3027792 TK.Half.Life NA 13.97 hours 1compartment NA NA Human Human +DTXSID3027792 Css NA 1.51 mg/L 3compartmentss NA 50% Human Human +DTXSID3027792 Css NA 7.117 mg/L 3compartmentss NA 95% Human Human +DTXSID3027792 Css NA 1.204 mg/L PBTK NA 50% Human Human +DTXSID3027792 Css NA 4.621 mg/L PBTK NA 95% Human Human +DTXSID3027792 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027792 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027792 Vd NA 0.8615 L/kg 1compartment NA NA Rat Human DTXSID3027792 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027792 TK.Half.Life NA 3.578 hours 1compartment NA NA Rat Human -DTXSID3027792 Css NA 0.2842 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027792 Css NA 1.883 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027792 Css NA 0.2399 mg/L PBTK NA 50% Rat Human -DTXSID3027792 Css NA 1.138 mg/L PBTK NA 95% Rat Human -DTXSID3027798 Clint NA 0.5624 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027798 Fup NA 0.73 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027798 Vd NA 2.121 L/kg 1compartment NA NA Human Human -DTXSID3027798 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027798 TK.Half.Life NA 9.874 hours 1compartment NA NA Human Human -DTXSID3027798 Css NA 0.4112 mg/L 3compartmentss NA 50% Human Human -DTXSID3027798 Css NA 3.207 mg/L 3compartmentss NA 95% Human Human -DTXSID3027798 Css NA 0.4403 mg/L PBTK NA 50% Human Human -DTXSID3027798 Css NA 2.315 mg/L PBTK NA 95% Human Human -DTXSID3027798 Clint NA 0.5624 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027798 Fup NA 0.73 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027798 Vd NA 2.103 L/kg 1compartment NA NA Rat Human +DTXSID3027792 TK.Half.Life NA 4.193 hours 1compartment NA NA Rat Human +DTXSID3027792 Css NA 0.09558 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027792 Css NA 0.3976 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027792 Css NA 0.07586 mg/L PBTK NA 50% Rat Human +DTXSID3027792 Css NA 0.2507 mg/L PBTK NA 95% Rat Human +DTXSID3027798 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027798 Fup 0.567 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027798 Vd NA 1.704 L/kg 1compartment NA NA Human Human +DTXSID3027798 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3027798 TK.Half.Life NA 19.44 hours 1compartment NA NA Human Human +DTXSID3027798 Css NA 0.8862 mg/L 3compartmentss NA 50% Human Human +DTXSID3027798 Css NA 7.323 mg/L 3compartmentss NA 95% Human Human +DTXSID3027798 Css NA 0.8673 mg/L PBTK NA 50% Human Human +DTXSID3027798 Css NA 4.869 mg/L PBTK NA 95% Human Human +DTXSID3027798 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027798 Fup 0.567 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027798 Vd NA 1.683 L/kg 1compartment NA NA Rat Human DTXSID3027798 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027798 TK.Half.Life NA 4.39 hours 1compartment NA NA Rat Human -DTXSID3027798 Css NA 0.1395 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027798 Css NA 1.081 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027798 Css NA 0.1488 mg/L PBTK NA 50% Rat Human -DTXSID3027798 Css NA 0.708 mg/L PBTK NA 95% Rat Human -DTXSID3027823 Clint NA 40.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027823 Fup NA 0.0432 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027823 Vd NA 2.187 L/kg 1compartment NA NA Human Human +DTXSID3027798 TK.Half.Life NA 6.545 hours 1compartment NA NA Rat Human +DTXSID3027798 Css NA 0.01693 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027798 Css NA 0.1633 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027798 Css NA 0.01607 mg/L PBTK NA 50% Rat Human +DTXSID3027798 Css NA 0.1127 mg/L PBTK NA 95% Rat Human +DTXSID3027823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027823 Fup 0.096 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027823 Vd NA 1.032 L/kg 1compartment NA NA Human Human DTXSID3027823 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027823 TK.Half.Life NA 8.102 hours 1compartment NA NA Human Human -DTXSID3027823 Css NA 0.4485 mg/L 3compartmentss NA 50% Human Human -DTXSID3027823 Css NA 3.345 mg/L 3compartmentss NA 95% Human Human -DTXSID3027823 Css NA 0.298 mg/L PBTK NA 50% Human Human -DTXSID3027823 Css NA 2.115 mg/L PBTK NA 95% Human Human -DTXSID3027823 Clint NA 40.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027823 Fup NA 0.0432 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027823 Vd NA 1.674 L/kg 1compartment NA NA Rat Human +DTXSID3027823 TK.Half.Life NA 2.714 hours 1compartment NA NA Human Human +DTXSID3027823 Css NA 0.2815 mg/L 3compartmentss NA 50% Human Human +DTXSID3027823 Css NA 2.334 mg/L 3compartmentss NA 95% Human Human +DTXSID3027823 Css NA 0.187 mg/L PBTK NA 50% Human Human +DTXSID3027823 Css NA 1.448 mg/L PBTK NA 95% Human Human +DTXSID3027823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027823 Fup 0.096 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027823 Vd NA 0.8888 L/kg 1compartment NA NA Rat Human DTXSID3027823 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027823 TK.Half.Life NA 2.639 hours 1compartment NA NA Rat Human -DTXSID3027823 Css NA 0.2512 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027823 Css NA 1.536 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027823 Css NA 0.1587 mg/L PBTK NA 50% Rat Human -DTXSID3027823 Css NA 0.9278 mg/L PBTK NA 95% Rat Human -DTXSID3027829 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027829 Fup NA 0.7672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027829 Vd NA 0.8971 L/kg 1compartment NA NA Human Human +DTXSID3027823 TK.Half.Life NA 1.342 hours 1compartment NA NA Rat Human +DTXSID3027823 Css NA 0.03673 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027823 Css NA 0.2327 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027823 Css NA 0.02371 mg/L PBTK NA 50% Rat Human +DTXSID3027823 Css NA 0.1411 mg/L PBTK NA 95% Rat Human +DTXSID3027829 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027829 Fup 0.698 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3027829 Vd NA 0.7692 L/kg 1compartment NA NA Human Human DTXSID3027829 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3027829 TK.Half.Life NA 7.582 hours 1compartment NA NA Human Human -DTXSID3027829 Css NA 1 mg/L 3compartmentss NA 50% Human Human -DTXSID3027829 Css NA 6.554 mg/L 3compartmentss NA 95% Human Human -DTXSID3027829 Css NA 0.8432 mg/L PBTK NA 50% Human Human -DTXSID3027829 Css NA 4.299 mg/L PBTK NA 95% Human Human -DTXSID3027829 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027829 Fup NA 0.7672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027829 Vd NA 0.9151 L/kg 1compartment NA NA Rat Human +DTXSID3027829 TK.Half.Life NA 7.133 hours 1compartment NA NA Human Human +DTXSID3027829 Css NA 1.055 mg/L 3compartmentss NA 50% Human Human +DTXSID3027829 Css NA 6.847 mg/L 3compartmentss NA 95% Human Human +DTXSID3027829 Css NA 0.8592 mg/L PBTK NA 50% Human Human +DTXSID3027829 Css NA 4.442 mg/L PBTK NA 95% Human Human +DTXSID3027829 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027829 Fup 0.698 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3027829 Vd NA 0.7936 L/kg 1compartment NA NA Rat Human DTXSID3027829 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3027829 TK.Half.Life NA 2.631 hours 1compartment NA NA Rat Human -DTXSID3027829 Css NA 0.2544 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027829 Css NA 1.619 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027829 Css NA 0.2078 mg/L PBTK NA 50% Rat Human -DTXSID3027829 Css NA 0.9702 mg/L PBTK NA 95% Rat Human -DTXSID3027875 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027875 Fup NA 0.0209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027875 Vd NA 3.123 L/kg 1compartment NA NA Human Human -DTXSID3027875 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID3027875 TK.Half.Life NA 123600 hours 1compartment NA NA Human Human -DTXSID3027875 Css NA 4464 mg/L 3compartmentss NA 50% Human Human -DTXSID3027875 Css NA 10620 mg/L 3compartmentss NA 95% Human Human -DTXSID3027875 Css NA 3104 mg/L PBTK NA 50% Human Human -DTXSID3027875 Css NA 7001 mg/L PBTK NA 95% Human Human -DTXSID3027875 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027875 Fup NA 0.0209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027875 Vd NA 2.339 L/kg 1compartment NA NA Rat Human -DTXSID3027875 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID3027875 TK.Half.Life NA 7709 hours 1compartment NA NA Rat Human -DTXSID3027875 Css NA 1226 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027875 Css NA 2147 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027875 Css NA 816.4 mg/L PBTK NA 50% Rat Human -DTXSID3027875 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID3027877 Clint NA 481.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027877 Fup NA 0.003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027877 Vd NA 473 L/kg 1compartment NA NA Human Human -DTXSID3027877 Days.Css NA 148 Days PBTK NA NA Human Human -DTXSID3027877 TK.Half.Life NA 653.9 hours 1compartment NA NA Human Human -DTXSID3027877 Css NA 0.001653 mg/L 3compartmentss NA 50% Human Human -DTXSID3027877 Css NA 0.01019 mg/L 3compartmentss NA 95% Human Human -DTXSID3027877 Css NA 0.1154 mg/L PBTK NA 50% Human Human -DTXSID3027877 Css NA 0.648 mg/L PBTK NA 95% Human Human -DTXSID3027877 Clint NA 481.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027877 Fup NA 0.003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027877 Vd NA 426.9 L/kg 1compartment NA NA Rat Human -DTXSID3027877 Days.Css NA 104 Days PBTK NA NA Rat Human -DTXSID3027877 TK.Half.Life NA 113.3 hours 1compartment NA NA Rat Human -DTXSID3027877 Css NA 0.0008392 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027877 Css NA 0.003634 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027877 Css NA 0.0623 mg/L PBTK NA 50% Rat Human -DTXSID3027877 Css NA 0.2715 mg/L PBTK NA 95% Rat Human -DTXSID3027902 Clint NA 0.2353 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027902 Fup NA 0.1497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3027902 Vd NA 3.091 L/kg 1compartment NA NA Human Human -DTXSID3027902 Days.Css NA 500 Days PBTK NA NA Human Human -DTXSID3027902 TK.Half.Life NA 1909 hours 1compartment NA NA Human Human -DTXSID3027902 Css NA 71.68 mg/L 3compartmentss NA 50% Human Human -DTXSID3027902 Css NA 223 mg/L 3compartmentss NA 95% Human Human -DTXSID3027902 Css NA 50.46 mg/L PBTK NA 50% Human Human -DTXSID3027902 Css NA 146.7 mg/L PBTK NA 95% Human Human -DTXSID3027902 Clint NA 0.2353 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027902 Fup NA 0.1497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3027902 Vd NA 2.321 L/kg 1compartment NA NA Rat Human -DTXSID3027902 Days.Css NA 181 Days PBTK NA NA Rat Human -DTXSID3027902 TK.Half.Life NA 180.8 hours 1compartment NA NA Rat Human -DTXSID3027902 Css NA 27.79 mg/L 3compartmentss NA 50% Rat Human -DTXSID3027902 Css NA 62.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID3027902 Css NA 18.66 mg/L PBTK NA 50% Rat Human -DTXSID3027902 Css NA 38.42 mg/L PBTK NA 95% Rat Human -DTXSID3028001 Clint NA 164.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3028001 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3028001 Vd NA 2.657 L/kg 1compartment NA NA Human Human +DTXSID3027829 TK.Half.Life NA 2.507 hours 1compartment NA NA Rat Human +DTXSID3027829 Css NA 0.06337 mg/L 3compartmentss NA 50% Rat Human +DTXSID3027829 Css NA 0.408 mg/L 3compartmentss NA 95% Rat Human +DTXSID3027829 Css NA 0.05146 mg/L PBTK NA 50% Rat Human +DTXSID3027829 Css NA 0.2496 mg/L PBTK NA 95% Rat Human +DTXSID3028001 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3028001 Fup 0.0916 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3028001 Vd NA 0.2699 L/kg 1compartment NA NA Human Human DTXSID3028001 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3028001 TK.Half.Life NA 9.923 hours 1compartment NA NA Human Human -DTXSID3028001 Css NA 0.431 mg/L 3compartmentss NA 50% Human Human -DTXSID3028001 Css NA 3.032 mg/L 3compartmentss NA 95% Human Human -DTXSID3028001 Css NA 0.2864 mg/L PBTK NA 50% Human Human -DTXSID3028001 Css NA 1.929 mg/L PBTK NA 95% Human Human -DTXSID3028001 Clint NA 164.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3028001 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3028001 Vd NA 1.981 L/kg 1compartment NA NA Rat Human +DTXSID3028001 TK.Half.Life NA 1.888 hours 1compartment NA NA Human Human +DTXSID3028001 Css NA 0.9222 mg/L 3compartmentss NA 50% Human Human +DTXSID3028001 Css NA 6.513 mg/L 3compartmentss NA 95% Human Human +DTXSID3028001 Css NA 0.5644 mg/L PBTK NA 50% Human Human +DTXSID3028001 Css NA 3.819 mg/L PBTK NA 95% Human Human +DTXSID3028001 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3028001 Fup 0.0916 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3028001 Vd NA 0.2704 L/kg 1compartment NA NA Rat Human DTXSID3028001 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3028001 TK.Half.Life NA 2.381 hours 1compartment NA NA Rat Human -DTXSID3028001 Css NA 0.2425 mg/L 3compartmentss NA 50% Rat Human -DTXSID3028001 Css NA 1.539 mg/L 3compartmentss NA 95% Rat Human -DTXSID3028001 Css NA 0.1533 mg/L PBTK NA 50% Rat Human -DTXSID3028001 Css NA 0.9244 mg/L PBTK NA 95% Rat Human -DTXSID3029150 Clint NA 0.3013 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029150 Fup NA 0.9148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029150 Vd NA 1.669 L/kg 1compartment NA NA Human Human -DTXSID3029150 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029150 TK.Half.Life NA 7.951 hours 1compartment NA NA Human Human -DTXSID3029150 Css NA 0.483 mg/L 3compartmentss NA 50% Human Human -DTXSID3029150 Css NA 2.089 mg/L 3compartmentss NA 95% Human Human -DTXSID3029150 Css NA 0.4764 mg/L PBTK NA 50% Human Human -DTXSID3029150 Css NA 1.574 mg/L PBTK NA 95% Human Human -DTXSID3029150 Clint NA 0.3013 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029150 Fup NA 0.9148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029150 Vd NA 1.709 L/kg 1compartment NA NA Rat Human +DTXSID3028001 TK.Half.Life NA 1.157 hours 1compartment NA NA Rat Human +DTXSID3028001 Css NA 0.04154 mg/L 3compartmentss NA 50% Rat Human +DTXSID3028001 Css NA 0.3326 mg/L 3compartmentss NA 95% Rat Human +DTXSID3028001 Css NA 0.0244 mg/L PBTK NA 50% Rat Human +DTXSID3028001 Css NA 0.1906 mg/L PBTK NA 95% Rat Human +DTXSID3028005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3028005 Fup 0.0213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3028005 Vd NA 1.403 L/kg 1compartment NA NA Human Human +DTXSID3028005 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3028005 TK.Half.Life NA 12.2 hours 1compartment NA NA Human Human +DTXSID3028005 Css NA 1.354 mg/L 3compartmentss NA 50% Human Human +DTXSID3028005 Css NA 11.96 mg/L 3compartmentss NA 95% Human Human +DTXSID3028005 Css NA 0.8469 mg/L PBTK NA 50% Human Human +DTXSID3028005 Css NA 7.38 mg/L PBTK NA 95% Human Human +DTXSID3028005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3028005 Fup 0.0213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3028005 Vd NA 1.042 L/kg 1compartment NA NA Rat Human +DTXSID3028005 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3028005 TK.Half.Life NA 4.834 hours 1compartment NA NA Rat Human +DTXSID3028005 Css NA 0.1767 mg/L 3compartmentss NA 50% Rat Human +DTXSID3028005 Css NA 1.261 mg/L 3compartmentss NA 95% Rat Human +DTXSID3028005 Css NA 0.1066 mg/L PBTK NA 50% Rat Human +DTXSID3028005 Css NA 0.729 mg/L PBTK NA 95% Rat Human +DTXSID3029150 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029150 Fup 0.767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029150 Vd NA 2.129 L/kg 1compartment NA NA Human Human +DTXSID3029150 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3029150 TK.Half.Life NA 17.96 hours 1compartment NA NA Human Human +DTXSID3029150 Css NA 0.6904 mg/L 3compartmentss NA 50% Human Human +DTXSID3029150 Css NA 5.012 mg/L 3compartmentss NA 95% Human Human +DTXSID3029150 Css NA 0.7168 mg/L PBTK NA 50% Human Human +DTXSID3029150 Css NA 3.523 mg/L PBTK NA 95% Human Human +DTXSID3029150 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029150 Fup 0.767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029150 Vd NA 2.16 L/kg 1compartment NA NA Rat Human DTXSID3029150 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029150 TK.Half.Life NA 3.326 hours 1compartment NA NA Rat Human -DTXSID3029150 Css NA 0.1497 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029150 Css NA 0.565 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029150 Css NA 0.1469 mg/L PBTK NA 50% Rat Human -DTXSID3029150 Css NA 0.4005 mg/L PBTK NA 95% Rat Human -DTXSID3029152 Clint NA 19.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029152 Fup NA 0.3549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029152 Vd NA 1.731 L/kg 1compartment NA NA Human Human +DTXSID3029150 TK.Half.Life NA 6.211 hours 1compartment NA NA Rat Human +DTXSID3029150 Css NA 0.01276 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029150 Css NA 0.114 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029150 Css NA 0.01277 mg/L PBTK NA 50% Rat Human +DTXSID3029150 Css NA 0.08375 mg/L PBTK NA 95% Rat Human +DTXSID3029152 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029152 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029152 Vd NA 1.243 L/kg 1compartment NA NA Human Human DTXSID3029152 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029152 TK.Half.Life NA 2.363 hours 1compartment NA NA Human Human -DTXSID3029152 Css NA 0.08035 mg/L 3compartmentss NA 50% Human Human -DTXSID3029152 Css NA 0.5607 mg/L 3compartmentss NA 95% Human Human -DTXSID3029152 Css NA 0.06276 mg/L PBTK NA 50% Human Human -DTXSID3029152 Css NA 0.3971 mg/L PBTK NA 95% Human Human -DTXSID3029152 Clint NA 19.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029152 Fup NA 0.3549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029152 Vd NA 1.392 L/kg 1compartment NA NA Rat Human +DTXSID3029152 TK.Half.Life NA 2.182 hours 1compartment NA NA Human Human +DTXSID3029152 Css NA 0.1186 mg/L 3compartmentss NA 50% Human Human +DTXSID3029152 Css NA 0.8574 mg/L 3compartmentss NA 95% Human Human +DTXSID3029152 Css NA 0.08368 mg/L PBTK NA 50% Human Human +DTXSID3029152 Css NA 0.5752 mg/L PBTK NA 95% Human Human +DTXSID3029152 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029152 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029152 Vd NA 0.9963 L/kg 1compartment NA NA Rat Human DTXSID3029152 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029152 TK.Half.Life NA 0.8967 hours 1compartment NA NA Rat Human -DTXSID3029152 Css NA 0.04306 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029152 Css NA 0.2253 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029152 Css NA 0.03256 mg/L PBTK NA 50% Rat Human -DTXSID3029152 Css NA 0.1542 mg/L PBTK NA 95% Rat Human +DTXSID3029152 TK.Half.Life NA 0.9064 hours 1compartment NA NA Rat Human +DTXSID3029152 Css NA 0.01526 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029152 Css NA 0.07809 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029152 Css NA 0.01064 mg/L PBTK NA 50% Rat Human +DTXSID3029152 Css NA 0.05166 mg/L PBTK NA 95% Rat Human DTXSID3029154 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3029154 Fup NA 0.9167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3029154 Vd NA 1.002 L/kg 1compartment NA NA Human Human DTXSID3029154 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3029154 TK.Half.Life NA 7.185 hours 1compartment NA NA Human Human -DTXSID3029154 Css NA 0.8366 mg/L 3compartmentss NA 50% Human Human -DTXSID3029154 Css NA 3.176 mg/L 3compartmentss NA 95% Human Human -DTXSID3029154 Css NA 0.7377 mg/L PBTK NA 50% Human Human -DTXSID3029154 Css NA 2.272 mg/L PBTK NA 95% Human Human +DTXSID3029154 Css NA 0.707 mg/L 3compartmentss NA 50% Human Human +DTXSID3029154 Css NA 2.792 mg/L 3compartmentss NA 95% Human Human +DTXSID3029154 Css NA 0.624 mg/L PBTK NA 50% Human Human +DTXSID3029154 Css NA 2.001 mg/L PBTK NA 95% Human Human DTXSID3029154 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3029154 Fup NA 0.9167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3029154 Vd NA 0.9936 L/kg 1compartment NA NA Rat Human DTXSID3029154 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3029154 TK.Half.Life NA 2.399 hours 1compartment NA NA Rat Human -DTXSID3029154 Css NA 0.213 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029154 Css NA 0.7899 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029154 Css NA 0.1845 mg/L PBTK NA 50% Rat Human -DTXSID3029154 Css NA 0.5183 mg/L PBTK NA 95% Rat Human -DTXSID3029158 Clint NA 0.06497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029158 Fup NA 0.8988 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029158 Vd NA 1.884 L/kg 1compartment NA NA Human Human +DTXSID3029154 Css NA 0.01255 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029154 Css NA 0.07006 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029154 Css NA 0.01076 mg/L PBTK NA 50% Rat Human +DTXSID3029154 Css NA 0.05273 mg/L PBTK NA 95% Rat Human +DTXSID3029158 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029158 Fup 0.755 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029158 Vd NA 1.639 L/kg 1compartment NA NA Human Human DTXSID3029158 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3029158 TK.Half.Life NA 12.26 hours 1compartment NA NA Human Human -DTXSID3029158 Css NA 0.6859 mg/L 3compartmentss NA 50% Human Human -DTXSID3029158 Css NA 4.327 mg/L 3compartmentss NA 95% Human Human -DTXSID3029158 Css NA 0.6842 mg/L PBTK NA 50% Human Human -DTXSID3029158 Css NA 3.024 mg/L PBTK NA 95% Human Human -DTXSID3029158 Clint NA 0.06497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029158 Fup NA 0.8988 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029158 Vd NA 1.92 L/kg 1compartment NA NA Rat Human +DTXSID3029158 TK.Half.Life NA 14.05 hours 1compartment NA NA Human Human +DTXSID3029158 Css NA 0.8556 mg/L 3compartmentss NA 50% Human Human +DTXSID3029158 Css NA 6.008 mg/L 3compartmentss NA 95% Human Human +DTXSID3029158 Css NA 0.8156 mg/L PBTK NA 50% Human Human +DTXSID3029158 Css NA 4.049 mg/L PBTK NA 95% Human Human +DTXSID3029158 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029158 Fup 0.755 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029158 Vd NA 1.668 L/kg 1compartment NA NA Rat Human DTXSID3029158 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029158 TK.Half.Life NA 4.478 hours 1compartment NA NA Rat Human -DTXSID3029158 Css NA 0.1824 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029158 Css NA 1.148 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029158 Css NA 0.1798 mg/L PBTK NA 50% Rat Human -DTXSID3029158 Css NA 0.744 mg/L PBTK NA 95% Rat Human +DTXSID3029158 TK.Half.Life NA 4.871 hours 1compartment NA NA Rat Human +DTXSID3029158 Css NA 0.05028 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029158 Css NA 0.3567 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029158 Css NA 0.04885 mg/L PBTK NA 50% Rat Human +DTXSID3029158 Css NA 0.2304 mg/L PBTK NA 95% Rat Human DTXSID3029231 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3029231 Fup NA 0.9594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3029231 Vd NA 0.9828 L/kg 1compartment NA NA Human Human DTXSID3029231 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3029231 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human -DTXSID3029231 Css NA 0.812 mg/L 3compartmentss NA 50% Human Human -DTXSID3029231 Css NA 2.939 mg/L 3compartmentss NA 95% Human Human -DTXSID3029231 Css NA 0.7177 mg/L PBTK NA 50% Human Human -DTXSID3029231 Css NA 2.156 mg/L PBTK NA 95% Human Human +DTXSID3029231 Css NA 0.6872 mg/L 3compartmentss NA 50% Human Human +DTXSID3029231 Css NA 2.514 mg/L 3compartmentss NA 95% Human Human +DTXSID3029231 Css NA 0.6062 mg/L PBTK NA 50% Human Human +DTXSID3029231 Css NA 1.845 mg/L PBTK NA 95% Human Human DTXSID3029231 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3029231 Fup NA 0.9594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3029231 Vd NA 0.984 L/kg 1compartment NA NA Rat Human DTXSID3029231 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3029231 TK.Half.Life NA 2.267 hours 1compartment NA NA Rat Human -DTXSID3029231 Css NA 0.2069 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029231 Css NA 0.6698 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029231 Css NA 0.1793 mg/L PBTK NA 50% Rat Human -DTXSID3029231 Css NA 0.449 mg/L PBTK NA 95% Rat Human -DTXSID3029233 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029233 Fup NA 0.105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029233 Vd NA 0.5447 L/kg 1compartment NA NA Human Human -DTXSID3029233 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3029233 TK.Half.Life NA 34.48 hours 1compartment NA NA Human Human -DTXSID3029233 Css NA 9.63 mg/L 3compartmentss NA 50% Human Human -DTXSID3029233 Css NA 44.43 mg/L 3compartmentss NA 95% Human Human -DTXSID3029233 Css NA 6.082 mg/L PBTK NA 50% Human Human -DTXSID3029233 Css NA 25.77 mg/L PBTK NA 95% Human Human -DTXSID3029233 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029233 Fup NA 0.105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029233 Vd NA 0.469 L/kg 1compartment NA NA Rat Human -DTXSID3029233 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3029233 TK.Half.Life NA 9.915 hours 1compartment NA NA Rat Human -DTXSID3029233 Css NA 2.7 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029233 Css NA 10.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029233 Css NA 1.601 mg/L PBTK NA 50% Rat Human -DTXSID3029233 Css NA 5.816 mg/L PBTK NA 95% Rat Human -DTXSID3029237 Clint NA 16.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029237 Fup NA 0.1869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029237 Vd NA 0.8357 L/kg 1compartment NA NA Human Human +DTXSID3029231 Css NA 0.01217 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029231 Css NA 0.06286 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029231 Css NA 0.01042 mg/L PBTK NA 50% Rat Human +DTXSID3029231 Css NA 0.04807 mg/L PBTK NA 95% Rat Human +DTXSID3029233 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029233 Fup 0.0583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029233 Vd NA 0.3034 L/kg 1compartment NA NA Human Human +DTXSID3029233 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3029233 TK.Half.Life NA 3.171 hours 1compartment NA NA Human Human +DTXSID3029233 Css NA 1.672 mg/L 3compartmentss NA 50% Human Human +DTXSID3029233 Css NA 11.44 mg/L 3compartmentss NA 95% Human Human +DTXSID3029233 Css NA 1.013 mg/L PBTK NA 50% Human Human +DTXSID3029233 Css NA 6.776 mg/L PBTK NA 95% Human Human +DTXSID3029233 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029233 Fup 0.0583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029233 Vd NA 0.2825 L/kg 1compartment NA NA Rat Human +DTXSID3029233 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3029233 TK.Half.Life NA 1.832 hours 1compartment NA NA Rat Human +DTXSID3029233 Css NA 0.2071 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029233 Css NA 1.075 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029233 Css NA 0.121 mg/L PBTK NA 50% Rat Human +DTXSID3029233 Css NA 0.6102 mg/L PBTK NA 95% Rat Human +DTXSID3029237 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029237 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029237 Vd NA 1.52 L/kg 1compartment NA NA Human Human DTXSID3029237 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029237 TK.Half.Life NA 1.646 hours 1compartment NA NA Human Human -DTXSID3029237 Css NA 0.1556 mg/L 3compartmentss NA 50% Human Human -DTXSID3029237 Css NA 1.055 mg/L 3compartmentss NA 95% Human Human -DTXSID3029237 Css NA 0.1075 mg/L PBTK NA 50% Human Human -DTXSID3029237 Css NA 0.6895 mg/L PBTK NA 95% Human Human -DTXSID3029237 Clint NA 16.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029237 Fup NA 0.1869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029237 Vd NA 0.7053 L/kg 1compartment NA NA Rat Human +DTXSID3029237 TK.Half.Life NA 2.034 hours 1compartment NA NA Human Human +DTXSID3029237 Css NA 0.07302 mg/L 3compartmentss NA 50% Human Human +DTXSID3029237 Css NA 0.5139 mg/L 3compartmentss NA 95% Human Human +DTXSID3029237 Css NA 0.05586 mg/L PBTK NA 50% Human Human +DTXSID3029237 Css NA 0.3611 mg/L PBTK NA 95% Human Human +DTXSID3029237 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029237 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029237 Vd NA 1.233 L/kg 1compartment NA NA Rat Human DTXSID3029237 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029237 TK.Half.Life NA 0.7689 hours 1compartment NA NA Rat Human -DTXSID3029237 Css NA 0.08325 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029237 Css NA 0.4203 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029237 Css NA 0.05458 mg/L PBTK NA 50% Rat Human -DTXSID3029237 Css NA 0.2553 mg/L PBTK NA 95% Rat Human +DTXSID3029237 TK.Half.Life NA 0.8048 hours 1compartment NA NA Rat Human +DTXSID3029237 Css NA 0.009016 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029237 Css NA 0.05033 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029237 Css NA 0.006915 mg/L PBTK NA 50% Rat Human +DTXSID3029237 Css NA 0.03485 mg/L PBTK NA 95% Rat Human DTXSID3029283 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3029283 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029283 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID3029283 Vd NA 0.3511 L/kg 1compartment NA NA Human Human DTXSID3029283 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029283 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID3029283 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID3029283 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID3029283 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID3029283 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID3029283 TK.Half.Life NA 7.031 hours 1compartment NA NA Human Human +DTXSID3029283 Css NA 2.035 mg/L 3compartmentss NA 50% Human Human +DTXSID3029283 Css NA 8.566 mg/L 3compartmentss NA 95% Human Human +DTXSID3029283 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID3029283 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID3029283 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3029283 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029283 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID3029283 Vd NA 0.365 L/kg 1compartment NA NA Rat Human DTXSID3029283 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029283 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID3029283 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029283 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029283 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID3029283 Css NA 1.313 mg/L PBTK NA 95% Rat Human -DTXSID3029287 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029287 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029287 Vd NA 0.9194 L/kg 1compartment NA NA Human Human +DTXSID3029283 TK.Half.Life NA 2.49 hours 1compartment NA NA Rat Human +DTXSID3029283 Css NA 0.03815 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029283 Css NA 0.226 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029283 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID3029283 Css NA 0.1369 mg/L PBTK NA 95% Rat Human +DTXSID3029287 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029287 Fup 0.788 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029287 Vd NA 0.6716 L/kg 1compartment NA NA Human Human DTXSID3029287 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029287 TK.Half.Life NA 5.981 hours 1compartment NA NA Human Human -DTXSID3029287 Css NA 0.7982 mg/L 3compartmentss NA 50% Human Human -DTXSID3029287 Css NA 5.706 mg/L 3compartmentss NA 95% Human Human -DTXSID3029287 Css NA 0.6987 mg/L PBTK NA 50% Human Human -DTXSID3029287 Css NA 3.672 mg/L PBTK NA 95% Human Human -DTXSID3029287 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029287 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029287 Vd NA 0.9375 L/kg 1compartment NA NA Rat Human +DTXSID3029287 TK.Half.Life NA 5.514 hours 1compartment NA NA Human Human +DTXSID3029287 Css NA 0.8641 mg/L 3compartmentss NA 50% Human Human +DTXSID3029287 Css NA 5.269 mg/L 3compartmentss NA 95% Human Human +DTXSID3029287 Css NA 0.6966 mg/L PBTK NA 50% Human Human +DTXSID3029287 Css NA 3.404 mg/L PBTK NA 95% Human Human +DTXSID3029287 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029287 Fup 0.788 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029287 Vd NA 0.7048 L/kg 1compartment NA NA Rat Human DTXSID3029287 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029287 TK.Half.Life NA 2.07 hours 1compartment NA NA Rat Human -DTXSID3029287 Css NA 0.2006 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029287 Css NA 1.275 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029287 Css NA 0.1725 mg/L PBTK NA 50% Rat Human -DTXSID3029287 Css NA 0.7787 mg/L PBTK NA 95% Rat Human -DTXSID3029289 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029289 Fup NA 0.8593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029289 Vd NA 1.31 L/kg 1compartment NA NA Human Human +DTXSID3029287 TK.Half.Life NA 1.973 hours 1compartment NA NA Rat Human +DTXSID3029287 Css NA 0.01643 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029287 Css NA 0.1251 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029287 Css NA 0.01267 mg/L PBTK NA 50% Rat Human +DTXSID3029287 Css NA 0.08048 mg/L PBTK NA 95% Rat Human +DTXSID3029289 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029289 Fup 0.707 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029289 Vd NA 0.9189 L/kg 1compartment NA NA Human Human DTXSID3029289 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029289 TK.Half.Life NA 9.94 hours 1compartment NA NA Human Human -DTXSID3029289 Css NA 0.8844 mg/L 3compartmentss NA 50% Human Human -DTXSID3029289 Css NA 5.258 mg/L 3compartmentss NA 95% Human Human -DTXSID3029289 Css NA 0.7974 mg/L PBTK NA 50% Human Human -DTXSID3029289 Css NA 3.566 mg/L PBTK NA 95% Human Human -DTXSID3029289 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029289 Fup NA 0.8593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029289 Vd NA 1.319 L/kg 1compartment NA NA Rat Human +DTXSID3029289 TK.Half.Life NA 8.416 hours 1compartment NA NA Human Human +DTXSID3029289 Css NA 1.014 mg/L 3compartmentss NA 50% Human Human +DTXSID3029289 Css NA 6.705 mg/L 3compartmentss NA 95% Human Human +DTXSID3029289 Css NA 0.8508 mg/L PBTK NA 50% Human Human +DTXSID3029289 Css NA 4.382 mg/L PBTK NA 95% Human Human +DTXSID3029289 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029289 Fup 0.707 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029289 Vd NA 0.9399 L/kg 1compartment NA NA Rat Human DTXSID3029289 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029289 TK.Half.Life NA 3.391 hours 1compartment NA NA Rat Human -DTXSID3029289 Css NA 0.2199 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029289 Css NA 1.404 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029289 Css NA 0.1955 mg/L PBTK NA 50% Rat Human -DTXSID3029289 Css NA 0.8685 mg/L PBTK NA 95% Rat Human +DTXSID3029289 TK.Half.Life NA 2.932 hours 1compartment NA NA Rat Human +DTXSID3029289 Css NA 0.06082 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029289 Css NA 0.4038 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029289 Css NA 0.05102 mg/L PBTK NA 50% Rat Human +DTXSID3029289 Css NA 0.249 mg/L PBTK NA 95% Rat Human DTXSID3029312 Clint NA 2.781 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3029312 Fup NA 0.0217 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029312 Vd NA 0.2112 L/kg 1compartment NA NA Human Human +DTXSID3029312 Vd NA 0.2109 L/kg 1compartment NA NA Human Human DTXSID3029312 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3029312 TK.Half.Life NA 11.37 hours 1compartment NA NA Human Human -DTXSID3029312 Css NA 9.855 mg/L 3compartmentss NA 50% Human Human -DTXSID3029312 Css NA 70.98 mg/L 3compartmentss NA 95% Human Human -DTXSID3029312 Css NA 5.859 mg/L PBTK NA 50% Human Human -DTXSID3029312 Css NA 41.1 mg/L PBTK NA 95% Human Human +DTXSID3029312 TK.Half.Life NA 11.36 hours 1compartment NA NA Human Human +DTXSID3029312 Css NA 9.578 mg/L 3compartmentss NA 50% Human Human +DTXSID3029312 Css NA 73.15 mg/L 3compartmentss NA 95% Human Human +DTXSID3029312 Css NA 5.705 mg/L PBTK NA 50% Human Human +DTXSID3029312 Css NA 42.04 mg/L PBTK NA 95% Human Human DTXSID3029312 Clint NA 2.781 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3029312 Fup NA 0.0217 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029312 Vd NA 0.2074 L/kg 1compartment NA NA Rat Human +DTXSID3029312 Vd NA 0.2072 L/kg 1compartment NA NA Rat Human DTXSID3029312 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029312 TK.Half.Life NA 6.558 hours 1compartment NA NA Rat Human -DTXSID3029312 Css NA 4.742 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029312 Css NA 29.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029312 Css NA 2.612 mg/L PBTK NA 50% Rat Human -DTXSID3029312 Css NA 16.01 mg/L PBTK NA 95% Rat Human -DTXSID3029362 Clint NA 5289 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029362 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029362 Vd NA 2.849 L/kg 1compartment NA NA Human Human -DTXSID3029362 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029362 TK.Half.Life NA 2.661 hours 1compartment NA NA Human Human -DTXSID3029362 Css NA 0.01388 mg/L 3compartmentss NA 50% Human Human -DTXSID3029362 Css NA 0.09223 mg/L 3compartmentss NA 95% Human Human -DTXSID3029362 Css NA 0.009423 mg/L PBTK NA 50% Human Human -DTXSID3029362 Css NA 0.06031 mg/L PBTK NA 95% Human Human -DTXSID3029362 Clint NA 5289 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029362 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029362 Vd NA 2.129 L/kg 1compartment NA NA Rat Human -DTXSID3029362 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029362 TK.Half.Life NA 0.8304 hours 1compartment NA NA Rat Human -DTXSID3029362 Css NA 0.007788 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029362 Css NA 0.04598 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029362 Css NA 0.005015 mg/L PBTK NA 50% Rat Human -DTXSID3029362 Css NA 0.02832 mg/L PBTK NA 95% Rat Human -DTXSID3029364 Clint NA 55.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029364 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029364 Vd NA 1.586 L/kg 1compartment NA NA Human Human +DTXSID3029312 TK.Half.Life NA 6.551 hours 1compartment NA NA Rat Human +DTXSID3029312 Css NA 1.074 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029312 Css NA 6.654 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029312 Css NA 0.6123 mg/L PBTK NA 50% Rat Human +DTXSID3029312 Css NA 3.74 mg/L PBTK NA 95% Rat Human +DTXSID3029362 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029362 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029362 Vd NA 2.947 L/kg 1compartment NA NA Human Human +DTXSID3029362 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID3029362 TK.Half.Life NA 61.83 hours 1compartment NA NA Human Human +DTXSID3029362 Css NA 2.661 mg/L 3compartmentss NA 50% Human Human +DTXSID3029362 Css NA 18.42 mg/L 3compartmentss NA 95% Human Human +DTXSID3029362 Css NA 1.819 mg/L PBTK NA 50% Human Human +DTXSID3029362 Css NA 11.85 mg/L PBTK NA 95% Human Human +DTXSID3029362 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029362 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029362 Vd NA 2.205 L/kg 1compartment NA NA Rat Human +DTXSID3029362 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID3029362 TK.Half.Life NA 10.4 hours 1compartment NA NA Rat Human +DTXSID3029362 Css NA 0.3464 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029362 Css NA 2.005 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029362 Css NA 0.2331 mg/L PBTK NA 50% Rat Human +DTXSID3029362 Css NA 1.307 mg/L PBTK NA 95% Rat Human +DTXSID3029364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029364 Fup 0.0511 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029364 Vd NA 1.825 L/kg 1compartment NA NA Human Human DTXSID3029364 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029364 TK.Half.Life NA 4.023 hours 1compartment NA NA Human Human -DTXSID3029364 Css NA 0.2772 mg/L 3compartmentss NA 50% Human Human -DTXSID3029364 Css NA 2.026 mg/L 3compartmentss NA 95% Human Human -DTXSID3029364 Css NA 0.1792 mg/L PBTK NA 50% Human Human -DTXSID3029364 Css NA 1.243 mg/L PBTK NA 95% Human Human -DTXSID3029364 Clint NA 55.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029364 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029364 Vd NA 1.189 L/kg 1compartment NA NA Rat Human +DTXSID3029364 TK.Half.Life NA 9.187 hours 1compartment NA NA Human Human +DTXSID3029364 Css NA 0.6624 mg/L 3compartmentss NA 50% Human Human +DTXSID3029364 Css NA 4.828 mg/L 3compartmentss NA 95% Human Human +DTXSID3029364 Css NA 0.4288 mg/L PBTK NA 50% Human Human +DTXSID3029364 Css NA 3.033 mg/L PBTK NA 95% Human Human +DTXSID3029364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029364 Fup 0.0511 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029364 Vd NA 1.369 L/kg 1compartment NA NA Rat Human DTXSID3029364 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029364 TK.Half.Life NA 1.486 hours 1compartment NA NA Rat Human -DTXSID3029364 Css NA 0.1595 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029364 Css NA 0.9635 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029364 Css NA 0.09622 mg/L PBTK NA 50% Rat Human -DTXSID3029364 Css NA 0.5697 mg/L PBTK NA 95% Rat Human -DTXSID3029572 Clint NA 16.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029572 Fup NA 0.1087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029572 Vd NA 1.533 L/kg 1compartment NA NA Human Human +DTXSID3029364 TK.Half.Life NA 3.199 hours 1compartment NA NA Rat Human +DTXSID3029364 Css NA 0.0854 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029364 Css NA 0.515 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029364 Css NA 0.05422 mg/L PBTK NA 50% Rat Human +DTXSID3029364 Css NA 0.3174 mg/L PBTK NA 95% Rat Human +DTXSID30293827 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30293827 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30293827 Vd NA 1.659 L/kg 1compartment NA NA Human Human +DTXSID30293827 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID30293827 TK.Half.Life NA 42.27 hours 1compartment NA NA Human Human +DTXSID30293827 Css NA 2.636 mg/L 3compartmentss NA 50% Human Human +DTXSID30293827 Css NA 9.983 mg/L 3compartmentss NA 95% Human Human +DTXSID30293827 Css NA 2.042 mg/L PBTK NA 50% Human Human +DTXSID30293827 Css NA 6.665 mg/L PBTK NA 95% Human Human +DTXSID30293827 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30293827 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30293827 Vd NA 0.3601 L/kg 1compartment NA NA Rat Human +DTXSID30293827 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID30293827 TK.Half.Life NA 30.74 hours 1compartment NA NA Rat Human +DTXSID30293827 Css NA 2.746 mg/L 3compartmentss NA 50% Rat Human +DTXSID30293827 Css NA 14.37 mg/L 3compartmentss NA 95% Rat Human +DTXSID30293827 Css NA 1.582 mg/L PBTK NA 50% Rat Human +DTXSID30293827 Css NA 8.084 mg/L PBTK NA 95% Rat Human +DTXSID3029572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029572 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029572 Vd NA 1.741 L/kg 1compartment NA NA Human Human DTXSID3029572 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029572 TK.Half.Life NA 4.958 hours 1compartment NA NA Human Human -DTXSID3029572 Css NA 0.3759 mg/L 3compartmentss NA 50% Human Human -DTXSID3029572 Css NA 2.731 mg/L 3compartmentss NA 95% Human Human -DTXSID3029572 Css NA 0.2501 mg/L PBTK NA 50% Human Human -DTXSID3029572 Css NA 1.72 mg/L PBTK NA 95% Human Human -DTXSID3029572 Clint NA 16.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029572 Fup NA 0.1087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029572 Vd NA 1.176 L/kg 1compartment NA NA Rat Human +DTXSID3029572 TK.Half.Life NA 4.051 hours 1compartment NA NA Human Human +DTXSID3029572 Css NA 0.2121 mg/L 3compartmentss NA 50% Human Human +DTXSID3029572 Css NA 1.649 mg/L 3compartmentss NA 95% Human Human +DTXSID3029572 Css NA 0.1463 mg/L PBTK NA 50% Human Human +DTXSID3029572 Css NA 1.067 mg/L PBTK NA 95% Human Human +DTXSID3029572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029572 Fup 0.146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029572 Vd NA 1.34 L/kg 1compartment NA NA Rat Human DTXSID3029572 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029572 TK.Half.Life NA 1.915 hours 1compartment NA NA Rat Human -DTXSID3029572 Css NA 0.2076 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029572 Css NA 1.165 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029572 Css NA 0.1312 mg/L PBTK NA 50% Rat Human -DTXSID3029572 Css NA 0.6946 mg/L PBTK NA 95% Rat Human -DTXSID3029607 Clint NA 6.575 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029607 Fup NA 0.3131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029607 Vd NA 1.267 L/kg 1compartment NA NA Human Human +DTXSID3029572 TK.Half.Life NA 1.48 hours 1compartment NA NA Rat Human +DTXSID3029572 Css NA 0.0273 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029572 Css NA 0.1614 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029572 Css NA 0.01866 mg/L PBTK NA 50% Rat Human +DTXSID3029572 Css NA 0.1025 mg/L PBTK NA 95% Rat Human +DTXSID3029607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029607 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029607 Vd NA 1.559 L/kg 1compartment NA NA Human Human DTXSID3029607 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029607 TK.Half.Life NA 3.218 hours 1compartment NA NA Human Human -DTXSID3029607 Css NA 0.2215 mg/L 3compartmentss NA 50% Human Human -DTXSID3029607 Css NA 1.368 mg/L 3compartmentss NA 95% Human Human -DTXSID3029607 Css NA 0.1682 mg/L PBTK NA 50% Human Human -DTXSID3029607 Css NA 0.9235 mg/L PBTK NA 95% Human Human -DTXSID3029607 Clint NA 6.575 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029607 Fup NA 0.3131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029607 Vd NA 1.052 L/kg 1compartment NA NA Rat Human +DTXSID3029607 TK.Half.Life NA 1.657 hours 1compartment NA NA Human Human +DTXSID3029607 Css NA 0.0455 mg/L 3compartmentss NA 50% Human Human +DTXSID3029607 Css NA 0.38 mg/L 3compartmentss NA 95% Human Human +DTXSID3029607 Css NA 0.03742 mg/L PBTK NA 50% Human Human +DTXSID3029607 Css NA 0.2829 mg/L PBTK NA 95% Human Human +DTXSID3029607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029607 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029607 Vd NA 1.301 L/kg 1compartment NA NA Rat Human DTXSID3029607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029607 TK.Half.Life NA 1.403 hours 1compartment NA NA Rat Human -DTXSID3029607 Css NA 0.1147 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029607 Css NA 0.5111 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029607 Css NA 0.08354 mg/L PBTK NA 50% Rat Human -DTXSID3029607 Css NA 0.3322 mg/L PBTK NA 95% Rat Human +DTXSID3029607 TK.Half.Life NA 0.6627 hours 1compartment NA NA Rat Human +DTXSID3029607 Css NA 0.0057 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029607 Css NA 0.03628 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029607 Css NA 0.004714 mg/L PBTK NA 50% Rat Human +DTXSID3029607 Css NA 0.02644 mg/L PBTK NA 95% Rat Human DTXSID3029651 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3029651 Fup NA 0.3644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029651 Vd NA 0.4776 L/kg 1compartment NA NA Human Human +DTXSID3029651 Vd NA 0.4467 L/kg 1compartment NA NA Human Human DTXSID3029651 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029651 TK.Half.Life NA 8.48 hours 1compartment NA NA Human Human -DTXSID3029651 Css NA 2.044 mg/L 3compartmentss NA 50% Human Human -DTXSID3029651 Css NA 8.572 mg/L 3compartmentss NA 95% Human Human -DTXSID3029651 Css NA 1.46 mg/L PBTK NA 50% Human Human -DTXSID3029651 Css NA 5.418 mg/L PBTK NA 95% Human Human +DTXSID3029651 TK.Half.Life NA 7.931 hours 1compartment NA NA Human Human +DTXSID3029651 Css NA 1.752 mg/L 3compartmentss NA 50% Human Human +DTXSID3029651 Css NA 7.173 mg/L 3compartmentss NA 95% Human Human +DTXSID3029651 Css NA 1.253 mg/L PBTK NA 50% Human Human +DTXSID3029651 Css NA 4.493 mg/L PBTK NA 95% Human Human DTXSID3029651 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3029651 Fup NA 0.3644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029651 Vd NA 0.4925 L/kg 1compartment NA NA Rat Human +DTXSID3029651 Vd NA 0.4653 L/kg 1compartment NA NA Rat Human DTXSID3029651 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029651 TK.Half.Life NA 2.979 hours 1compartment NA NA Rat Human -DTXSID3029651 Css NA 0.5591 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029651 Css NA 1.974 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029651 Css NA 0.3822 mg/L PBTK NA 50% Rat Human -DTXSID3029651 Css NA 1.16 mg/L PBTK NA 95% Rat Human -DTXSID3029653 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029653 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029653 Vd NA 0.3458 L/kg 1compartment NA NA Human Human -DTXSID3029653 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029653 TK.Half.Life NA 8.147 hours 1compartment NA NA Human Human -DTXSID3029653 Css NA 2.926 mg/L 3compartmentss NA 50% Human Human -DTXSID3029653 Css NA 11.09 mg/L 3compartmentss NA 95% Human Human -DTXSID3029653 Css NA 1.921 mg/L PBTK NA 50% Human Human -DTXSID3029653 Css NA 6.719 mg/L PBTK NA 95% Human Human -DTXSID3029653 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029653 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029653 Vd NA 0.3464 L/kg 1compartment NA NA Rat Human -DTXSID3029653 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029653 TK.Half.Life NA 2.779 hours 1compartment NA NA Rat Human -DTXSID3029653 Css NA 0.8088 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029653 Css NA 2.594 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029653 Css NA 0.5041 mg/L PBTK NA 50% Rat Human -DTXSID3029653 Css NA 1.474 mg/L PBTK NA 95% Rat Human -DTXSID3029655 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029655 Fup NA 0.687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029655 Vd NA 2.408 L/kg 1compartment NA NA Human Human +DTXSID3029651 TK.Half.Life NA 2.814 hours 1compartment NA NA Rat Human +DTXSID3029651 Css NA 0.03192 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029651 Css NA 0.1983 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029651 Css NA 0.02178 mg/L PBTK NA 50% Rat Human +DTXSID3029651 Css NA 0.1232 mg/L PBTK NA 95% Rat Human +DTXSID3029655 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029655 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029655 Vd NA 2.03 L/kg 1compartment NA NA Human Human DTXSID3029655 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3029655 TK.Half.Life NA 22.68 hours 1compartment NA NA Human Human -DTXSID3029655 Css NA 0.8192 mg/L 3compartmentss NA 50% Human Human -DTXSID3029655 Css NA 6.553 mg/L 3compartmentss NA 95% Human Human -DTXSID3029655 Css NA 0.8922 mg/L PBTK NA 50% Human Human -DTXSID3029655 Css NA 4.541 mg/L PBTK NA 95% Human Human -DTXSID3029655 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029655 Fup NA 0.687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029655 Vd NA 2.425 L/kg 1compartment NA NA Rat Human +DTXSID3029655 TK.Half.Life NA 18.98 hours 1compartment NA NA Human Human +DTXSID3029655 Css NA 0.8437 mg/L 3compartmentss NA 50% Human Human +DTXSID3029655 Css NA 6.34 mg/L 3compartmentss NA 95% Human Human +DTXSID3029655 Css NA 0.8694 mg/L PBTK NA 50% Human Human +DTXSID3029655 Css NA 4.423 mg/L PBTK NA 95% Human Human +DTXSID3029655 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029655 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029655 Vd NA 2.043 L/kg 1compartment NA NA Rat Human DTXSID3029655 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029655 TK.Half.Life NA 7.782 hours 1compartment NA NA Rat Human -DTXSID3029655 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029655 Css NA 1.635 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029655 Css NA 0.2246 mg/L PBTK NA 50% Rat Human -DTXSID3029655 Css NA 1.069 mg/L PBTK NA 95% Rat Human -DTXSID3029815 Clint NA 71.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029815 Fup NA 0.1316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029815 Vd NA 4.257 L/kg 1compartment NA NA Human Human -DTXSID3029815 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029815 TK.Half.Life NA 1.905 hours 1compartment NA NA Human Human -DTXSID3029815 Css NA 0.004678 mg/L 3compartmentss NA 50% Human Human -DTXSID3029815 Css NA 0.04751 mg/L 3compartmentss NA 95% Human Human -DTXSID3029815 Css NA 0.006031 mg/L PBTK NA 50% Human Human -DTXSID3029815 Css NA 0.04629 mg/L PBTK NA 95% Human Human -DTXSID3029815 Clint NA 71.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029815 Fup NA 0.1316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029815 Vd NA 4.124 L/kg 1compartment NA NA Rat Human -DTXSID3029815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029815 TK.Half.Life NA 0.8417 hours 1compartment NA NA Rat Human -DTXSID3029815 Css NA 0.00248 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029815 Css NA 0.022 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029815 Css NA 0.003199 mg/L PBTK NA 50% Rat Human -DTXSID3029815 Css NA 0.02144 mg/L PBTK NA 95% Rat Human -DTXSID3029869 Clint NA 42.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029869 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3029869 Vd NA 0.2369 L/kg 1compartment NA NA Human Human +DTXSID3029655 TK.Half.Life NA 6.508 hours 1compartment NA NA Rat Human +DTXSID3029655 Css NA 0.04914 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029655 Css NA 0.3721 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029655 Css NA 0.05168 mg/L PBTK NA 50% Rat Human +DTXSID3029655 Css NA 0.2466 mg/L PBTK NA 95% Rat Human +DTXSID3029869 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029869 Fup 0.0329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3029869 Vd NA 0.3531 L/kg 1compartment NA NA Human Human DTXSID3029869 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3029869 TK.Half.Life NA 2.272 hours 1compartment NA NA Human Human -DTXSID3029869 Css NA 1.67 mg/L 3compartmentss NA 50% Human Human -DTXSID3029869 Css NA 17.4 mg/L 3compartmentss NA 95% Human Human -DTXSID3029869 Css NA 0.9798 mg/L PBTK NA 50% Human Human -DTXSID3029869 Css NA 10.03 mg/L PBTK NA 95% Human Human -DTXSID3029869 Clint NA 42.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029869 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3029869 Vd NA 0.2144 L/kg 1compartment NA NA Rat Human +DTXSID3029869 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human +DTXSID3029869 Css NA 3.053 mg/L 3compartmentss NA 50% Human Human +DTXSID3029869 Css NA 24.26 mg/L 3compartmentss NA 95% Human Human +DTXSID3029869 Css NA 1.846 mg/L PBTK NA 50% Human Human +DTXSID3029869 Css NA 14.45 mg/L PBTK NA 95% Human Human +DTXSID3029869 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029869 Fup 0.0329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3029869 Vd NA 0.3102 L/kg 1compartment NA NA Rat Human DTXSID3029869 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3029869 TK.Half.Life NA 1.367 hours 1compartment NA NA Rat Human -DTXSID3029869 Css NA 0.957 mg/L 3compartmentss NA 50% Rat Human -DTXSID3029869 Css NA 8.264 mg/L 3compartmentss NA 95% Rat Human -DTXSID3029869 Css NA 0.5252 mg/L PBTK NA 50% Rat Human -DTXSID3029869 Css NA 4.482 mg/L PBTK NA 95% Rat Human -DTXSID3030189 Clint NA 1.115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3030189 Fup NA 0.1055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3030189 Vd NA 1.707 L/kg 1compartment NA NA Human Human -DTXSID3030189 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID3030189 TK.Half.Life NA 50.01 hours 1compartment NA NA Human Human -DTXSID3030189 Css NA 4.138 mg/L 3compartmentss NA 50% Human Human -DTXSID3030189 Css NA 18.43 mg/L 3compartmentss NA 95% Human Human -DTXSID3030189 Css NA 2.793 mg/L PBTK NA 50% Human Human -DTXSID3030189 Css NA 11.3 mg/L PBTK NA 95% Human Human -DTXSID3030189 Clint NA 1.115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3030189 Fup NA 0.1055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3030189 Vd NA 1.301 L/kg 1compartment NA NA Rat Human -DTXSID3030189 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3030189 TK.Half.Life NA 14.77 hours 1compartment NA NA Rat Human -DTXSID3030189 Css NA 1.783 mg/L 3compartmentss NA 50% Rat Human -DTXSID3030189 Css NA 6.394 mg/L 3compartmentss NA 95% Rat Human -DTXSID3030189 Css NA 1.135 mg/L PBTK NA 50% Rat Human -DTXSID3030189 Css NA 3.665 mg/L PBTK NA 95% Rat Human -DTXSID3030428 Clint NA 3.782 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3030428 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3030428 Vd NA 0.9112 L/kg 1compartment NA NA Human Human +DTXSID3029869 TK.Half.Life NA 3.421 hours 1compartment NA NA Rat Human +DTXSID3029869 Css NA 0.3794 mg/L 3compartmentss NA 50% Rat Human +DTXSID3029869 Css NA 2.361 mg/L 3compartmentss NA 95% Rat Human +DTXSID3029869 Css NA 0.2227 mg/L PBTK NA 50% Rat Human +DTXSID3029869 Css NA 1.338 mg/L PBTK NA 95% Rat Human +DTXSID3030056 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3030056 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3030056 Vd NA 11.48 L/kg 1compartment NA NA Human Human +DTXSID3030056 Days.Css NA 11150 Days PBTK NA NA Human Human +DTXSID3030056 TK.Half.Life NA 546200 hours 1compartment NA NA Human Human +DTXSID3030056 Css NA 2352 mg/L 3compartmentss NA 50% Human Human +DTXSID3030056 Css NA 5806 mg/L 3compartmentss NA 95% Human Human +DTXSID3030056 Css NA 3102 mg/L PBTK NA 50% Human Human +DTXSID3030056 Css NA 6861 mg/L PBTK NA 95% Human Human +DTXSID3030056 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3030056 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3030056 Vd NA 9.094 L/kg 1compartment NA NA Rat Human +DTXSID3030056 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID3030056 TK.Half.Life NA 35900 hours 1compartment NA NA Rat Human +DTXSID3030056 Css NA 37.25 mg/L 3compartmentss NA 50% Rat Human +DTXSID3030056 Css NA 180.1 mg/L 3compartmentss NA 95% Rat Human +DTXSID3030056 Css NA 50.38 mg/L PBTK NA 50% Rat Human +DTXSID3030056 Css NA 227 mg/L PBTK NA 95% Rat Human +DTXSID3030189 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3030189 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3030189 Vd NA 1.446 L/kg 1compartment NA NA Human Human +DTXSID3030189 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3030189 TK.Half.Life NA 5.138 hours 1compartment NA NA Human Human +DTXSID3030189 Css NA 0.4217 mg/L 3compartmentss NA 50% Human Human +DTXSID3030189 Css NA 3.166 mg/L 3compartmentss NA 95% Human Human +DTXSID3030189 Css NA 0.2734 mg/L PBTK NA 50% Human Human +DTXSID3030189 Css NA 1.962 mg/L PBTK NA 95% Human Human +DTXSID3030189 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3030189 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3030189 Vd NA 1.098 L/kg 1compartment NA NA Rat Human +DTXSID3030189 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3030189 TK.Half.Life NA 2.017 hours 1compartment NA NA Rat Human +DTXSID3030189 Css NA 0.05544 mg/L 3compartmentss NA 50% Rat Human +DTXSID3030189 Css NA 0.3273 mg/L 3compartmentss NA 95% Rat Human +DTXSID3030189 Css NA 0.03515 mg/L PBTK NA 50% Rat Human +DTXSID3030189 Css NA 0.197 mg/L PBTK NA 95% Rat Human +DTXSID3030428 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3030428 Fup 0.516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3030428 Vd NA 0.6213 L/kg 1compartment NA NA Human Human DTXSID3030428 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3030428 TK.Half.Life NA 1.186 hours 1compartment NA NA Human Human -DTXSID3030428 Css NA 0.1151 mg/L 3compartmentss NA 50% Human Human -DTXSID3030428 Css NA 1.011 mg/L 3compartmentss NA 95% Human Human -DTXSID3030428 Css NA 0.09936 mg/L PBTK NA 50% Human Human -DTXSID3030428 Css NA 0.7224 mg/L PBTK NA 95% Human Human -DTXSID3030428 Clint NA 3.782 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3030428 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3030428 Vd NA 0.9247 L/kg 1compartment NA NA Rat Human +DTXSID3030428 TK.Half.Life NA 7.819 hours 1compartment NA NA Human Human +DTXSID3030428 Css NA 1.391 mg/L 3compartmentss NA 50% Human Human +DTXSID3030428 Css NA 7.287 mg/L 3compartmentss NA 95% Human Human +DTXSID3030428 Css NA 1.068 mg/L PBTK NA 50% Human Human +DTXSID3030428 Css NA 4.621 mg/L PBTK NA 95% Human Human +DTXSID3030428 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3030428 Fup 0.516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3030428 Vd NA 0.6267 L/kg 1compartment NA NA Rat Human DTXSID3030428 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3030428 TK.Half.Life NA 0.629 hours 1compartment NA NA Rat Human -DTXSID3030428 Css NA 0.05171 mg/L 3compartmentss NA 50% Rat Human -DTXSID3030428 Css NA 0.3749 mg/L 3compartmentss NA 95% Rat Human -DTXSID3030428 Css NA 0.04429 mg/L PBTK NA 50% Rat Human -DTXSID3030428 Css NA 0.2341 mg/L PBTK NA 95% Rat Human +DTXSID3030428 TK.Half.Life NA 2.679 hours 1compartment NA NA Rat Human +DTXSID3030428 Css NA 0.08658 mg/L 3compartmentss NA 50% Rat Human +DTXSID3030428 Css NA 0.421 mg/L 3compartmentss NA 95% Rat Human +DTXSID3030428 Css NA 0.06579 mg/L PBTK NA 50% Rat Human +DTXSID3030428 Css NA 0.257 mg/L PBTK NA 95% Rat Human DTXSID3030636 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3030636 Fup 0.157 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3030636 Vd NA 0.933 L/kg 1compartment NA NA Human Human -DTXSID3030636 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID3030636 TK.Half.Life NA 38.83 hours 1compartment NA NA Human Human -DTXSID3030636 Css NA 4.623 mg/L 3compartmentss NA 50% Human Human -DTXSID3030636 Css NA 14.38 mg/L 3compartmentss NA 95% Human Human -DTXSID3030636 Css NA 3.266 mg/L PBTK NA 50% Human Human -DTXSID3030636 Css NA 9.279 mg/L PBTK NA 95% Human Human +DTXSID3030636 Vd NA 0.4093 L/kg 1compartment NA NA Human Human +DTXSID3030636 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3030636 TK.Half.Life NA 17 hours 1compartment NA NA Human Human +DTXSID3030636 Css NA 2.719 mg/L 3compartmentss NA 50% Human Human +DTXSID3030636 Css NA 8.814 mg/L 3compartmentss NA 95% Human Human +DTXSID3030636 Css NA 1.754 mg/L PBTK NA 50% Human Human +DTXSID3030636 Css NA 5.416 mg/L PBTK NA 95% Human Human DTXSID3030636 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3030636 Fup 0.157 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3030636 Vd NA 0.9101 L/kg 1compartment NA NA Rat Human -DTXSID3030636 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3030636 TK.Half.Life NA 12.81 hours 1compartment NA NA Rat Human -DTXSID3030636 Css NA 1.271 mg/L 3compartmentss NA 50% Rat Human -DTXSID3030636 Css NA 3.133 mg/L 3compartmentss NA 95% Rat Human -DTXSID3030636 Css NA 0.8584 mg/L PBTK NA 50% Rat Human -DTXSID3030636 Css NA 1.885 mg/L PBTK NA 95% Rat Human -DTXSID3031444 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3031444 Fup NA 0.5797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3031444 Vd NA 0.7569 L/kg 1compartment NA NA Human Human -DTXSID3031444 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3031444 TK.Half.Life NA 8.531 hours 1compartment NA NA Human Human -DTXSID3031444 Css NA 1.269 mg/L 3compartmentss NA 50% Human Human -DTXSID3031444 Css NA 8.81 mg/L 3compartmentss NA 95% Human Human -DTXSID3031444 Css NA 1.021 mg/L PBTK NA 50% Human Human -DTXSID3031444 Css NA 5.55 mg/L PBTK NA 95% Human Human -DTXSID3031444 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3031444 Fup NA 0.5797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3031444 Vd NA 0.7487 L/kg 1compartment NA NA Rat Human -DTXSID3031444 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3031444 TK.Half.Life NA 2.855 hours 1compartment NA NA Rat Human -DTXSID3031444 Css NA 0.3324 mg/L 3compartmentss NA 50% Rat Human -DTXSID3031444 Css NA 2.162 mg/L 3compartmentss NA 95% Rat Human -DTXSID3031444 Css NA 0.2572 mg/L PBTK NA 50% Rat Human -DTXSID3031444 Css NA 1.27 mg/L PBTK NA 95% Rat Human +DTXSID3030636 Vd NA 0.3813 L/kg 1compartment NA NA Rat Human +DTXSID3030636 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3030636 TK.Half.Life NA 5.365 hours 1compartment NA NA Rat Human +DTXSID3030636 Css NA 0.0147 mg/L 3compartmentss NA 50% Rat Human +DTXSID3030636 Css NA 0.04771 mg/L 3compartmentss NA 95% Rat Human +DTXSID3030636 Css NA 0.008974 mg/L PBTK NA 50% Rat Human +DTXSID3030636 Css NA 0.02795 mg/L PBTK NA 95% Rat Human DTXSID3031521 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3031521 Fup 0.88 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID3031521 Vd NA 0.5693 L/kg 1compartment NA NA Human Human +DTXSID3031521 Vd NA 0.5544 L/kg 1compartment NA NA Human Human DTXSID3031521 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3031521 TK.Half.Life NA 4.186 hours 1compartment NA NA Human Human -DTXSID3031521 Css NA 1.095 mg/L 3compartmentss NA 50% Human Human -DTXSID3031521 Css NA 5.609 mg/L 3compartmentss NA 95% Human Human -DTXSID3031521 Css NA 0.7794 mg/L PBTK NA 50% Human Human -DTXSID3031521 Css NA 3.466 mg/L PBTK NA 95% Human Human +DTXSID3031521 TK.Half.Life NA 4.075 hours 1compartment NA NA Human Human +DTXSID3031521 Css NA 0.8977 mg/L 3compartmentss NA 50% Human Human +DTXSID3031521 Css NA 4.074 mg/L 3compartmentss NA 95% Human Human +DTXSID3031521 Css NA 0.66 mg/L PBTK NA 50% Human Human +DTXSID3031521 Css NA 2.995 mg/L PBTK NA 95% Human Human DTXSID3031521 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3031521 Fup 0.88 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID3031521 Vd NA 0.5856 L/kg 1compartment NA NA Rat Human +DTXSID3031521 Vd NA 0.5891 L/kg 1compartment NA NA Rat Human DTXSID3031521 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3031521 TK.Half.Life NA 1.467 hours 1compartment NA NA Rat Human -DTXSID3031521 Css NA 0.2804 mg/L 3compartmentss NA 50% Rat Human -DTXSID3031521 Css NA 1.439 mg/L 3compartmentss NA 95% Rat Human -DTXSID3031521 Css NA 0.1918 mg/L PBTK NA 50% Rat Human -DTXSID3031521 Css NA 0.8253 mg/L PBTK NA 95% Rat Human -DTXSID3031860 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3031860 Fup 0.00284 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3031860 Vd NA 0.1922 L/kg 1compartment NA NA Human Human -DTXSID3031860 Days.Css NA 125 Days PBTK NA NA Human Human -DTXSID3031860 TK.Half.Life NA 437.9 hours 1compartment NA NA Human Human -DTXSID3031860 Css NA 211.9 mg/L 3compartmentss NA 50% Human Human -DTXSID3031860 Css NA 677.2 mg/L 3compartmentss NA 95% Human Human -DTXSID3031860 Css NA 124.2 mg/L PBTK NA 50% Human Human -DTXSID3031860 Css NA 386.7 mg/L PBTK NA 95% Human Human -DTXSID3031860 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3031860 Fup 0.00284 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3031860 Vd NA 0.1857 L/kg 1compartment NA NA Rat Human -DTXSID3031860 Days.Css NA 36 Days PBTK NA NA Rat Human -DTXSID3031860 TK.Half.Life NA 144.2 hours 1compartment NA NA Rat Human -DTXSID3031860 Css NA 59.64 mg/L 3compartmentss NA 50% Rat Human -DTXSID3031860 Css NA 155.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID3031860 Css NA 32.68 mg/L PBTK NA 50% Rat Human -DTXSID3031860 Css NA 84.58 mg/L PBTK NA 95% Rat Human -DTXSID3031862 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3031862 Fup 0.01676 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3031862 Vd NA 0.228 L/kg 1compartment NA NA Human Human -DTXSID3031862 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID3031862 TK.Half.Life NA 88 hours 1compartment NA NA Human Human -DTXSID3031862 Css NA 65.81 mg/L 3compartmentss NA 50% Human Human -DTXSID3031862 Css NA 398.6 mg/L 3compartmentss NA 95% Human Human -DTXSID3031862 Css NA 38.99 mg/L PBTK NA 50% Human Human -DTXSID3031862 Css NA 231.8 mg/L PBTK NA 95% Human Human -DTXSID3031862 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3031862 Fup 0.01676 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3031862 Vd NA 0.2225 L/kg 1compartment NA NA Rat Human -DTXSID3031862 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID3031862 TK.Half.Life NA 29.27 hours 1compartment NA NA Rat Human -DTXSID3031862 Css NA 18.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID3031862 Css NA 100.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID3031862 Css NA 10.39 mg/L PBTK NA 50% Rat Human -DTXSID3031862 Css NA 54.69 mg/L PBTK NA 95% Rat Human -DTXSID3031864 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3031864 Fup 0.00363 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3031864 Vd NA 0.3428 L/kg 1compartment NA NA Human Human -DTXSID3031864 Days.Css NA 164 Days PBTK NA NA Human Human -DTXSID3031864 TK.Half.Life NA 617.8 hours 1compartment NA NA Human Human -DTXSID3031864 Css NA 290 mg/L 3compartmentss NA 50% Human Human -DTXSID3031864 Css NA 1391 mg/L 3compartmentss NA 95% Human Human -DTXSID3031864 Css NA 186.7 mg/L PBTK NA 50% Human Human -DTXSID3031864 Css NA 822.7 mg/L PBTK NA 95% Human Human -DTXSID3031864 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID3031864 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID3031864 Css NA 58.43 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3031864 Css NA 331.8 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3031521 TK.Half.Life NA 1.476 hours 1compartment NA NA Rat Human +DTXSID3031521 Css NA 0.01626 mg/L 3compartmentss NA 50% Rat Human +DTXSID3031521 Css NA 0.09536 mg/L 3compartmentss NA 95% Rat Human +DTXSID3031521 Css NA 0.01206 mg/L PBTK NA 50% Rat Human +DTXSID3031521 Css NA 0.07165 mg/L PBTK NA 95% Rat Human +DTXSID3031654 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3031654 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3031654 Vd NA 0.9041 L/kg 1compartment NA NA Human Human +DTXSID3031654 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3031654 TK.Half.Life NA 2.237 hours 1compartment NA NA Human Human +DTXSID3031654 Css NA 0.1743 mg/L 3compartmentss NA 50% Human Human +DTXSID3031654 Css NA 1.202 mg/L 3compartmentss NA 95% Human Human +DTXSID3031654 Css NA 0.1356 mg/L PBTK NA 50% Human Human +DTXSID3031654 Css NA 0.8201 mg/L PBTK NA 95% Human Human +DTXSID3031654 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3031654 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3031654 Vd NA 0.7916 L/kg 1compartment NA NA Rat Human +DTXSID3031654 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3031654 TK.Half.Life NA 1.086 hours 1compartment NA NA Rat Human +DTXSID3031654 Css NA 0.005922 mg/L 3compartmentss NA 50% Rat Human +DTXSID3031654 Css NA 0.04512 mg/L 3compartmentss NA 95% Rat Human +DTXSID3031654 Css NA 0.004511 mg/L PBTK NA 50% Rat Human +DTXSID3031654 Css NA 0.0307 mg/L PBTK NA 95% Rat Human +DTXSID3032129 Clint NA 19.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3032129 Fup NA 0.0081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3032129 Vd NA 22.3 L/kg 1compartment NA NA Human Human +DTXSID3032129 Days.Css NA 177 Days PBTK NA NA Human Human +DTXSID3032129 TK.Half.Life NA 748.5 hours 1compartment NA NA Human Human +DTXSID3032129 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human +DTXSID3032129 Css NA 6.338 mg/L 3compartmentss NA 95% Human Human +DTXSID3032129 Css NA 2.352 mg/L PBTK NA 50% Human Human +DTXSID3032129 Css NA 14.16 mg/L PBTK NA 95% Human Human +DTXSID3032129 Clint NA 19.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3032129 Fup NA 0.0081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3032129 Vd NA 18.19 L/kg 1compartment NA NA Rat Human +DTXSID3032129 Days.Css NA 107 Days PBTK NA NA Rat Human +DTXSID3032129 TK.Half.Life NA 108.6 hours 1compartment NA NA Rat Human +DTXSID3032129 Css NA 0.0336 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032129 Css NA 0.2525 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032129 Css NA 0.08269 mg/L PBTK NA 50% Rat Human +DTXSID3032129 Css NA 0.582 mg/L PBTK NA 95% Rat Human DTXSID3032337 Clint 31.35 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3032337 Fup NA 0.0327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032337 Vd NA 3.047 L/kg 1compartment NA NA Human Human +DTXSID3032337 Fup 0.00769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032337 Vd NA 2.774 L/kg 1compartment NA NA Human Human DTXSID3032337 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3032337 TK.Half.Life NA 41.43 hours 1compartment NA NA Human Human -DTXSID3032337 Css NA 1.655 mg/L 3compartmentss NA 50% Human Human -DTXSID3032337 Css NA 10.27 mg/L 3compartmentss NA 95% Human Human -DTXSID3032337 Css NA 1.143 mg/L PBTK NA 50% Human Human -DTXSID3032337 Css NA 6.872 mg/L PBTK NA 95% Human Human +DTXSID3032337 TK.Half.Life NA 43.16 hours 1compartment NA NA Human Human +DTXSID3032337 Css NA 2.042 mg/L 3compartmentss NA 50% Human Human +DTXSID3032337 Css NA 14.74 mg/L 3compartmentss NA 95% Human Human +DTXSID3032337 Css NA 1.372 mg/L PBTK NA 50% Human Human +DTXSID3032337 Css NA 9.637 mg/L PBTK NA 95% Human Human DTXSID3032337 Clint 31.35 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID3032337 Fup NA 0.0327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032337 Vd NA 2.282 L/kg 1compartment NA NA Rat Human +DTXSID3032337 Fup 0.00769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032337 Vd NA 2.071 L/kg 1compartment NA NA Rat Human DTXSID3032337 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3032337 TK.Half.Life NA 6.406 hours 1compartment NA NA Rat Human -DTXSID3032337 Css NA 0.9237 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032337 Css NA 5.076 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032337 Css NA 0.609 mg/L PBTK NA 50% Rat Human -DTXSID3032337 Css NA 3.277 mg/L PBTK NA 95% Rat Human -DTXSID3032389 Clint NA 102.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032389 Fup NA 0.0433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032389 Vd NA 3.065 L/kg 1compartment NA NA Human Human -DTXSID3032389 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3032389 TK.Half.Life NA 14.23 hours 1compartment NA NA Human Human -DTXSID3032389 Css NA 0.4872 mg/L 3compartmentss NA 50% Human Human -DTXSID3032389 Css NA 3.134 mg/L 3compartmentss NA 95% Human Human -DTXSID3032389 Css NA 0.3381 mg/L PBTK NA 50% Human Human -DTXSID3032389 Css NA 2.094 mg/L PBTK NA 95% Human Human -DTXSID3032389 Clint NA 102.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032389 Fup NA 0.0433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032389 Vd NA 2.297 L/kg 1compartment NA NA Rat Human -DTXSID3032389 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032389 TK.Half.Life NA 2.467 hours 1compartment NA NA Rat Human -DTXSID3032389 Css NA 0.2741 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032389 Css NA 1.431 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032389 Css NA 0.1816 mg/L PBTK NA 50% Rat Human -DTXSID3032389 Css NA 0.9169 mg/L PBTK NA 95% Rat Human -DTXSID3032416 Clint NA 32.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032416 Fup NA 0.0702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032416 Vd NA 2.554 L/kg 1compartment NA NA Human Human +DTXSID3032337 TK.Half.Life NA 8.658 hours 1compartment NA NA Rat Human +DTXSID3032337 Css NA 0.2697 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032337 Css NA 1.734 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032337 Css NA 0.1784 mg/L PBTK NA 50% Rat Human +DTXSID3032337 Css NA 1.109 mg/L PBTK NA 95% Rat Human +DTXSID3032389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032389 Fup 0.0268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032389 Vd NA 2.927 L/kg 1compartment NA NA Human Human +DTXSID3032389 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3032389 TK.Half.Life NA 46.74 hours 1compartment NA NA Human Human +DTXSID3032389 Css NA 1.998 mg/L 3compartmentss NA 50% Human Human +DTXSID3032389 Css NA 14.02 mg/L 3compartmentss NA 95% Human Human +DTXSID3032389 Css NA 1.372 mg/L PBTK NA 50% Human Human +DTXSID3032389 Css NA 9.273 mg/L PBTK NA 95% Human Human +DTXSID3032389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032389 Fup 0.0268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032389 Vd NA 2.191 L/kg 1compartment NA NA Rat Human +DTXSID3032389 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3032389 TK.Half.Life NA 8.135 hours 1compartment NA NA Rat Human +DTXSID3032389 Css NA 0.2602 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032389 Css NA 1.508 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032389 Css NA 0.176 mg/L PBTK NA 50% Rat Human +DTXSID3032389 Css NA 0.9805 mg/L PBTK NA 95% Rat Human +DTXSID3032416 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032416 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032416 Vd NA 1.766 L/kg 1compartment NA NA Human Human DTXSID3032416 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3032416 TK.Half.Life NA 10.94 hours 1compartment NA NA Human Human -DTXSID3032416 Css NA 0.49 mg/L 3compartmentss NA 50% Human Human -DTXSID3032416 Css NA 3.137 mg/L 3compartmentss NA 95% Human Human -DTXSID3032416 Css NA 0.3331 mg/L PBTK NA 50% Human Human -DTXSID3032416 Css NA 2.061 mg/L PBTK NA 95% Human Human -DTXSID3032416 Clint NA 32.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032416 Fup NA 0.0702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032416 Vd NA 1.919 L/kg 1compartment NA NA Rat Human +DTXSID3032416 TK.Half.Life NA 4.627 hours 1compartment NA NA Human Human +DTXSID3032416 Css NA 0.26 mg/L 3compartmentss NA 50% Human Human +DTXSID3032416 Css NA 1.953 mg/L 3compartmentss NA 95% Human Human +DTXSID3032416 Css NA 0.1775 mg/L PBTK NA 50% Human Human +DTXSID3032416 Css NA 1.246 mg/L PBTK NA 95% Human Human +DTXSID3032416 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032416 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032416 Vd NA 1.352 L/kg 1compartment NA NA Rat Human DTXSID3032416 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032416 TK.Half.Life NA 2.789 hours 1compartment NA NA Rat Human -DTXSID3032416 Css NA 0.2735 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032416 Css NA 1.408 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032416 Css NA 0.1774 mg/L PBTK NA 50% Rat Human -DTXSID3032416 Css NA 0.8922 mg/L PBTK NA 95% Rat Human +DTXSID3032416 TK.Half.Life NA 1.673 hours 1compartment NA NA Rat Human +DTXSID3032416 Css NA 0.0341 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032416 Css NA 0.1904 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032416 Css NA 0.02284 mg/L PBTK NA 50% Rat Human +DTXSID3032416 Css NA 0.1205 mg/L PBTK NA 95% Rat Human DTXSID3032464 Clint 141 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3032464 Fup NA 0.0149 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032464 Vd NA 2.802 L/kg 1compartment NA NA Human Human +DTXSID3032464 Fup 0.00925 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032464 Vd NA 2.636 L/kg 1compartment NA NA Human Human DTXSID3032464 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3032464 TK.Half.Life NA 9.624 hours 1compartment NA NA Human Human -DTXSID3032464 Css NA 0.366 mg/L 3compartmentss NA 50% Human Human -DTXSID3032464 Css NA 2.493 mg/L 3compartmentss NA 95% Human Human -DTXSID3032464 Css NA 0.248 mg/L PBTK NA 50% Human Human -DTXSID3032464 Css NA 1.608 mg/L PBTK NA 95% Human Human +DTXSID3032464 TK.Half.Life NA 9.765 hours 1compartment NA NA Human Human +DTXSID3032464 Css NA 0.4093 mg/L 3compartmentss NA 50% Human Human +DTXSID3032464 Css NA 3.028 mg/L 3compartmentss NA 95% Human Human +DTXSID3032464 Css NA 0.2731 mg/L PBTK NA 50% Human Human +DTXSID3032464 Css NA 1.963 mg/L PBTK NA 95% Human Human DTXSID3032464 Clint 141 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3032464 Fup NA 0.0149 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032464 Vd NA 2.095 L/kg 1compartment NA NA Rat Human +DTXSID3032464 Fup 0.00925 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032464 Vd NA 1.966 L/kg 1compartment NA NA Rat Human DTXSID3032464 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032464 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human -DTXSID3032464 Css NA 0.2057 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032464 Css NA 1.161 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032464 Css NA 0.132 mg/L PBTK NA 50% Rat Human -DTXSID3032464 Css NA 0.7234 mg/L PBTK NA 95% Rat Human +DTXSID3032464 TK.Half.Life NA 2.376 hours 1compartment NA NA Rat Human +DTXSID3032464 Css NA 0.05386 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032464 Css NA 0.3475 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032464 Css NA 0.03513 mg/L PBTK NA 50% Rat Human +DTXSID3032464 Css NA 0.2245 mg/L PBTK NA 95% Rat Human DTXSID3032541 Clint NA 2.679 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3032541 Fup NA 0.1069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032541 Vd NA 2.751 L/kg 1compartment NA NA Human Human -DTXSID3032541 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID3032541 TK.Half.Life NA 96.4 hours 1compartment NA NA Human Human -DTXSID3032541 Css NA 4.581 mg/L 3compartmentss NA 50% Human Human -DTXSID3032541 Css NA 21.6 mg/L 3compartmentss NA 95% Human Human -DTXSID3032541 Css NA 3.194 mg/L PBTK NA 50% Human Human -DTXSID3032541 Css NA 14.17 mg/L PBTK NA 95% Human Human +DTXSID3032541 Vd NA 1.468 L/kg 1compartment NA NA Human Human +DTXSID3032541 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3032541 TK.Half.Life NA 20.28 hours 1compartment NA NA Human Human +DTXSID3032541 Css NA 1.932 mg/L 3compartmentss NA 50% Human Human +DTXSID3032541 Css NA 10.77 mg/L 3compartmentss NA 95% Human Human +DTXSID3032541 Css NA 1.288 mg/L PBTK NA 50% Human Human +DTXSID3032541 Css NA 6.783 mg/L PBTK NA 95% Human Human DTXSID3032541 Clint NA 2.679 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3032541 Fup NA 0.1069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032541 Vd NA 2.071 L/kg 1compartment NA NA Rat Human -DTXSID3032541 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID3032541 TK.Half.Life NA 17.99 hours 1compartment NA NA Rat Human -DTXSID3032541 Css NA 2.27 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032541 Css NA 7.493 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032541 Css NA 1.51 mg/L PBTK NA 50% Rat Human -DTXSID3032541 Css NA 4.687 mg/L PBTK NA 95% Rat Human +DTXSID3032541 Vd NA 1.128 L/kg 1compartment NA NA Rat Human +DTXSID3032541 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3032541 TK.Half.Life NA 7.369 hours 1compartment NA NA Rat Human +DTXSID3032541 Css NA 0.2192 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032541 Css NA 0.905 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032541 Css NA 0.1426 mg/L PBTK NA 50% Rat Human +DTXSID3032541 Css NA 0.5323 mg/L PBTK NA 95% Rat Human DTXSID3032547 Clint 127 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3032547 Fup NA 0.0645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032547 Vd NA 2.125 L/kg 1compartment NA NA Human Human +DTXSID3032547 Fup 0.0282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032547 Vd NA 1.57 L/kg 1compartment NA NA Human Human DTXSID3032547 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3032547 TK.Half.Life NA 3.237 hours 1compartment NA NA Human Human -DTXSID3032547 Css NA 0.104 mg/L 3compartmentss NA 50% Human Human -DTXSID3032547 Css NA 0.7711 mg/L 3compartmentss NA 95% Human Human -DTXSID3032547 Css NA 0.06926 mg/L PBTK NA 50% Human Human -DTXSID3032547 Css NA 0.4922 mg/L PBTK NA 95% Human Human +DTXSID3032547 TK.Half.Life NA 3.138 hours 1compartment NA NA Human Human +DTXSID3032547 Css NA 0.188 mg/L 3compartmentss NA 50% Human Human +DTXSID3032547 Css NA 1.733 mg/L 3compartmentss NA 95% Human Human +DTXSID3032547 Css NA 0.1184 mg/L PBTK NA 50% Human Human +DTXSID3032547 Css NA 1.052 mg/L PBTK NA 95% Human Human DTXSID3032547 Clint 127 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID3032547 Fup NA 0.0645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032547 Vd NA 1.597 L/kg 1compartment NA NA Rat Human +DTXSID3032547 Fup 0.0282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032547 Vd NA 1.169 L/kg 1compartment NA NA Rat Human DTXSID3032547 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032547 TK.Half.Life NA 1.04 hours 1compartment NA NA Rat Human -DTXSID3032547 Css NA 0.05899 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032547 Css NA 0.347 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032547 Css NA 0.03714 mg/L PBTK NA 50% Rat Human -DTXSID3032547 Css NA 0.2077 mg/L PBTK NA 95% Rat Human +DTXSID3032547 TK.Half.Life NA 1.135 hours 1compartment NA NA Rat Human +DTXSID3032547 Css NA 0.0245 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032547 Css NA 0.1948 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032547 Css NA 0.01505 mg/L PBTK NA 50% Rat Human +DTXSID3032547 Css NA 0.1133 mg/L PBTK NA 95% Rat Human DTXSID3032549 Clint 35.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3032549 Fup 0.05719 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3032549 Vd NA 1.8 L/kg 1compartment NA NA Human Human DTXSID3032549 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3032549 TK.Half.Life NA 5.747 hours 1compartment NA NA Human Human -DTXSID3032549 Css NA 0.3763 mg/L 3compartmentss NA 50% Human Human -DTXSID3032549 Css NA 2.837 mg/L 3compartmentss NA 95% Human Human -DTXSID3032549 Css NA 0.2469 mg/L PBTK NA 50% Human Human -DTXSID3032549 Css NA 1.805 mg/L PBTK NA 95% Human Human +DTXSID3032549 Css NA 0.3633 mg/L 3compartmentss NA 50% Human Human +DTXSID3032549 Css NA 2.723 mg/L 3compartmentss NA 95% Human Human +DTXSID3032549 Css NA 0.2358 mg/L PBTK NA 50% Human Human +DTXSID3032549 Css NA 1.676 mg/L PBTK NA 95% Human Human DTXSID3032549 Clint 35.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3032549 Fup 0.05719 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3032549 Vd NA 1.348 L/kg 1compartment NA NA Rat Human DTXSID3032549 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3032549 TK.Half.Life NA 2.006 hours 1compartment NA NA Rat Human -DTXSID3032549 Css NA 0.2128 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032549 Css NA 1.286 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032549 Css NA 0.1312 mg/L PBTK NA 50% Rat Human -DTXSID3032549 Css NA 0.7644 mg/L PBTK NA 95% Rat Human -DTXSID3032620 Clint NA 13.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032620 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032620 Vd NA 3.041 L/kg 1compartment NA NA Human Human -DTXSID3032620 Days.Css NA 25 Days PBTK NA NA Human Human -DTXSID3032620 TK.Half.Life NA 134.3 hours 1compartment NA NA Human Human -DTXSID3032620 Css NA 5.669 mg/L 3compartmentss NA 50% Human Human -DTXSID3032620 Css NA 33.42 mg/L 3compartmentss NA 95% Human Human -DTXSID3032620 Css NA 3.907 mg/L PBTK NA 50% Human Human -DTXSID3032620 Css NA 22.46 mg/L PBTK NA 95% Human Human -DTXSID3032620 Clint NA 13.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032620 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032620 Vd NA 2.276 L/kg 1compartment NA NA Rat Human -DTXSID3032620 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID3032620 TK.Half.Life NA 19.67 hours 1compartment NA NA Rat Human -DTXSID3032620 Css NA 3.186 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032620 Css NA 15.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032620 Css NA 2.09 mg/L PBTK NA 50% Rat Human -DTXSID3032620 Css NA 9.722 mg/L PBTK NA 95% Rat Human +DTXSID3032549 Css NA 0.04741 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032549 Css NA 0.3002 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032549 Css NA 0.0302 mg/L PBTK NA 50% Rat Human +DTXSID3032549 Css NA 0.1854 mg/L PBTK NA 95% Rat Human +DTXSID3032591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032591 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032591 Vd NA 0.6666 L/kg 1compartment NA NA Human Human +DTXSID3032591 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3032591 TK.Half.Life NA 9.208 hours 1compartment NA NA Human Human +DTXSID3032591 Css NA 1.465 mg/L 3compartmentss NA 50% Human Human +DTXSID3032591 Css NA 6.833 mg/L 3compartmentss NA 95% Human Human +DTXSID3032591 Css NA 1.127 mg/L PBTK NA 50% Human Human +DTXSID3032591 Css NA 4.402 mg/L PBTK NA 95% Human Human +DTXSID3032591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032591 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032591 Vd NA 0.6592 L/kg 1compartment NA NA Rat Human +DTXSID3032591 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3032591 TK.Half.Life NA 3.085 hours 1compartment NA NA Rat Human +DTXSID3032591 Css NA 0.09188 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032591 Css NA 0.3975 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032591 Css NA 0.07026 mg/L PBTK NA 50% Rat Human +DTXSID3032591 Css NA 0.2459 mg/L PBTK NA 95% Rat Human +DTXSID3032620 Clint 5.2 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID3032620 Fup 0.0117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032620 Vd NA 3.088 L/kg 1compartment NA NA Human Human +DTXSID3032620 Days.Css NA 80 Days PBTK NA NA Human Human +DTXSID3032620 TK.Half.Life NA 353.1 hours 1compartment NA NA Human Human +DTXSID3032620 Css NA 14.01 mg/L 3compartmentss NA 50% Human Human +DTXSID3032620 Css NA 90.47 mg/L 3compartmentss NA 95% Human Human +DTXSID3032620 Css NA 9.727 mg/L PBTK NA 50% Human Human +DTXSID3032620 Css NA 60.91 mg/L PBTK NA 95% Human Human +DTXSID3032620 Clint 5.2 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human +DTXSID3032620 Fup 0.0117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032620 Vd NA 2.312 L/kg 1compartment NA NA Rat Human +DTXSID3032620 Days.Css NA 43 Days PBTK NA NA Rat Human +DTXSID3032620 TK.Half.Life NA 47.77 hours 1compartment NA NA Rat Human +DTXSID3032620 Css NA 1.822 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032620 Css NA 9.538 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032620 Css NA 1.245 mg/L PBTK NA 50% Rat Human +DTXSID3032620 Css NA 6.303 mg/L PBTK NA 95% Rat Human DTXSID3032622 Clint NA 0.166 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3032622 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032622 Vd NA 0.9175 L/kg 1compartment NA NA Human Human +DTXSID3032622 Vd NA 0.9144 L/kg 1compartment NA NA Human Human DTXSID3032622 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3032622 TK.Half.Life NA 4.738 hours 1compartment NA NA Human Human -DTXSID3032622 Css NA 0.6242 mg/L 3compartmentss NA 50% Human Human -DTXSID3032622 Css NA 4.245 mg/L 3compartmentss NA 95% Human Human -DTXSID3032622 Css NA 0.538 mg/L PBTK NA 50% Human Human -DTXSID3032622 Css NA 2.786 mg/L PBTK NA 95% Human Human +DTXSID3032622 TK.Half.Life NA 4.722 hours 1compartment NA NA Human Human +DTXSID3032622 Css NA 0.5244 mg/L 3compartmentss NA 50% Human Human +DTXSID3032622 Css NA 3.309 mg/L 3compartmentss NA 95% Human Human +DTXSID3032622 Css NA 0.4508 mg/L PBTK NA 50% Human Human +DTXSID3032622 Css NA 2.214 mg/L PBTK NA 95% Human Human DTXSID3032622 Clint NA 0.166 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3032622 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032622 Vd NA 0.911 L/kg 1compartment NA NA Rat Human +DTXSID3032622 Vd NA 0.9088 L/kg 1compartment NA NA Rat Human DTXSID3032622 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032622 TK.Half.Life NA 1.78 hours 1compartment NA NA Rat Human -DTXSID3032622 Css NA 0.1808 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032622 Css NA 1.161 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032622 Css NA 0.1525 mg/L PBTK NA 50% Rat Human -DTXSID3032622 Css NA 0.7 mg/L PBTK NA 95% Rat Human -DTXSID3032626 Clint NA 118.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032626 Fup NA 0.0905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032626 Vd NA 0.7584 L/kg 1compartment NA NA Human Human +DTXSID3032622 TK.Half.Life NA 1.776 hours 1compartment NA NA Rat Human +DTXSID3032622 Css NA 0.01081 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032622 Css NA 0.08643 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032622 Css NA 0.009104 mg/L PBTK NA 50% Rat Human +DTXSID3032622 Css NA 0.0565 mg/L PBTK NA 95% Rat Human +DTXSID3032626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032626 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032626 Vd NA 0.9081 L/kg 1compartment NA NA Human Human DTXSID3032626 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3032626 TK.Half.Life NA 0.9369 hours 1compartment NA NA Human Human -DTXSID3032626 Css NA 0.06156 mg/L 3compartmentss NA 50% Human Human -DTXSID3032626 Css NA 0.5162 mg/L 3compartmentss NA 95% Human Human -DTXSID3032626 Css NA 0.03901 mg/L PBTK NA 50% Human Human -DTXSID3032626 Css NA 0.3156 mg/L PBTK NA 95% Human Human -DTXSID3032626 Clint NA 118.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032626 Fup NA 0.0905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032626 Vd NA 0.6003 L/kg 1compartment NA NA Rat Human +DTXSID3032626 TK.Half.Life NA 2.013 hours 1compartment NA NA Human Human +DTXSID3032626 Css NA 0.2132 mg/L 3compartmentss NA 50% Human Human +DTXSID3032626 Css NA 1.676 mg/L 3compartmentss NA 95% Human Human +DTXSID3032626 Css NA 0.139 mg/L PBTK NA 50% Human Human +DTXSID3032626 Css NA 1.037 mg/L PBTK NA 95% Human Human +DTXSID3032626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032626 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032626 Vd NA 0.7196 L/kg 1compartment NA NA Rat Human DTXSID3032626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032626 TK.Half.Life NA 0.3699 hours 1compartment NA NA Rat Human -DTXSID3032626 Css NA 0.03506 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032626 Css NA 0.2444 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032626 Css NA 0.02092 mg/L PBTK NA 50% Rat Human -DTXSID3032626 Css NA 0.1399 mg/L PBTK NA 95% Rat Human +DTXSID3032626 TK.Half.Life NA 0.8794 hours 1compartment NA NA Rat Human +DTXSID3032626 Css NA 0.02738 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032626 Css NA 0.1721 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032626 Css NA 0.01755 mg/L PBTK NA 50% Rat Human +DTXSID3032626 Css NA 0.1035 mg/L PBTK NA 95% Rat Human DTXSID3032628 Clint 16.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3032628 Fup 0.06119 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3032628 Vd NA 2.507 L/kg 1compartment NA NA Human Human DTXSID3032628 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID3032628 TK.Half.Life NA 20.17 hours 1compartment NA NA Human Human -DTXSID3032628 Css NA 1.038 mg/L 3compartmentss NA 50% Human Human -DTXSID3032628 Css NA 6.542 mg/L 3compartmentss NA 95% Human Human -DTXSID3032628 Css NA 0.7028 mg/L PBTK NA 50% Human Human -DTXSID3032628 Css NA 4.284 mg/L PBTK NA 95% Human Human +DTXSID3032628 Css NA 1.009 mg/L 3compartmentss NA 50% Human Human +DTXSID3032628 Css NA 6.759 mg/L 3compartmentss NA 95% Human Human +DTXSID3032628 Css NA 0.6826 mg/L PBTK NA 50% Human Human +DTXSID3032628 Css NA 4.375 mg/L PBTK NA 95% Human Human DTXSID3032628 Clint 16.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3032628 Fup 0.06119 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3032628 Vd NA 1.881 L/kg 1compartment NA NA Rat Human DTXSID3032628 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID3032628 TK.Half.Life NA 5.063 hours 1compartment NA NA Rat Human -DTXSID3032628 Css NA 0.5765 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032628 Css NA 2.776 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032628 Css NA 0.3724 mg/L PBTK NA 50% Rat Human -DTXSID3032628 Css NA 1.762 mg/L PBTK NA 95% Rat Human -DTXSID3032670 Clint NA 1.715 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032670 Fup NA 0.0356 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032670 Vd NA 0.2612 L/kg 1compartment NA NA Human Human -DTXSID3032670 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3032670 TK.Half.Life NA 12.46 hours 1compartment NA NA Human Human -DTXSID3032670 Css NA 8.62 mg/L 3compartmentss NA 50% Human Human -DTXSID3032670 Css NA 46.73 mg/L 3compartmentss NA 95% Human Human -DTXSID3032670 Css NA 5.208 mg/L PBTK NA 50% Human Human -DTXSID3032670 Css NA 27.46 mg/L PBTK NA 95% Human Human -DTXSID3032670 Clint NA 1.715 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032670 Fup NA 0.0356 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032670 Vd NA 0.2522 L/kg 1compartment NA NA Rat Human +DTXSID3032628 Css NA 0.131 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032628 Css NA 0.6778 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032628 Css NA 0.08713 mg/L PBTK NA 50% Rat Human +DTXSID3032628 Css NA 0.437 mg/L PBTK NA 95% Rat Human +DTXSID3032670 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032670 Fup 0.052 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032670 Vd NA 0.2988 L/kg 1compartment NA NA Human Human +DTXSID3032670 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3032670 TK.Half.Life NA 1.261 hours 1compartment NA NA Human Human +DTXSID3032670 Css NA 0.5854 mg/L 3compartmentss NA 50% Human Human +DTXSID3032670 Css NA 5.254 mg/L 3compartmentss NA 95% Human Human +DTXSID3032670 Css NA 0.3595 mg/L PBTK NA 50% Human Human +DTXSID3032670 Css NA 3.135 mg/L PBTK NA 95% Human Human +DTXSID3032670 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032670 Fup 0.052 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032670 Vd NA 0.2886 L/kg 1compartment NA NA Rat Human DTXSID3032670 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032670 TK.Half.Life NA 6.583 hours 1compartment NA NA Rat Human -DTXSID3032670 Css NA 3.959 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032670 Css NA 16.42 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032670 Css NA 2.23 mg/L PBTK NA 50% Rat Human -DTXSID3032670 Css NA 8.985 mg/L PBTK NA 95% Rat Human -DTXSID3032751 Clint NA 3.892 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032751 Fup NA 0.2614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032751 Vd NA 1.674 L/kg 1compartment NA NA Human Human +DTXSID3032670 TK.Half.Life NA 0.7641 hours 1compartment NA NA Rat Human +DTXSID3032670 Css NA 0.07719 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032670 Css NA 0.5187 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032670 Css NA 0.04604 mg/L PBTK NA 50% Rat Human +DTXSID3032670 Css NA 0.2976 mg/L PBTK NA 95% Rat Human +DTXSID30326861 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30326861 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30326861 Vd NA 0.5151 L/kg 1compartment NA NA Human Human +DTXSID30326861 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30326861 TK.Half.Life NA 1.637 hours 1compartment NA NA Human Human +DTXSID30326861 Css NA 0.308 mg/L 3compartmentss NA 50% Human Human +DTXSID30326861 Css NA 1.783 mg/L 3compartmentss NA 95% Human Human +DTXSID30326861 Css NA 0.2096 mg/L PBTK NA 50% Human Human +DTXSID30326861 Css NA 1.15 mg/L PBTK NA 95% Human Human +DTXSID30326861 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30326861 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30326861 Vd NA 0.4892 L/kg 1compartment NA NA Rat Human +DTXSID30326861 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30326861 TK.Half.Life NA 0.9016 hours 1compartment NA NA Rat Human +DTXSID30326861 Css NA 0.0356 mg/L 3compartmentss NA 50% Rat Human +DTXSID30326861 Css NA 0.1553 mg/L 3compartmentss NA 95% Rat Human +DTXSID30326861 Css NA 0.02372 mg/L PBTK NA 50% Rat Human +DTXSID30326861 Css NA 0.09562 mg/L PBTK NA 95% Rat Human +DTXSID3032751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032751 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032751 Vd NA 1.971 L/kg 1compartment NA NA Human Human DTXSID3032751 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3032751 TK.Half.Life NA 6.222 hours 1compartment NA NA Human Human -DTXSID3032751 Css NA 0.3198 mg/L 3compartmentss NA 50% Human Human -DTXSID3032751 Css NA 2 mg/L 3compartmentss NA 95% Human Human -DTXSID3032751 Css NA 0.2761 mg/L PBTK NA 50% Human Human -DTXSID3032751 Css NA 1.465 mg/L PBTK NA 95% Human Human -DTXSID3032751 Clint NA 3.892 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032751 Fup NA 0.2614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032751 Vd NA 1.672 L/kg 1compartment NA NA Rat Human +DTXSID3032751 TK.Half.Life NA 2.047 hours 1compartment NA NA Human Human +DTXSID3032751 Css NA 0.04399 mg/L 3compartmentss NA 50% Human Human +DTXSID3032751 Css NA 0.38 mg/L 3compartmentss NA 95% Human Human +DTXSID3032751 Css NA 0.04201 mg/L PBTK NA 50% Human Human +DTXSID3032751 Css NA 0.3021 mg/L PBTK NA 95% Human Human +DTXSID3032751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032751 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032751 Vd NA 1.957 L/kg 1compartment NA NA Rat Human DTXSID3032751 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032751 TK.Half.Life NA 3.606 hours 1compartment NA NA Rat Human -DTXSID3032751 Css NA 0.1572 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032751 Css NA 0.7172 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032751 Css NA 0.1319 mg/L PBTK NA 50% Rat Human -DTXSID3032751 Css NA 0.4776 mg/L PBTK NA 95% Rat Human -DTXSID3032759 Clint NA 3.142 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032759 Fup NA 0.1876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032759 Vd NA 0.9481 L/kg 1compartment NA NA Human Human +DTXSID3032751 TK.Half.Life NA 1.107 hours 1compartment NA NA Rat Human +DTXSID3032751 Css NA 0.005388 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032751 Css NA 0.0369 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032751 Css NA 0.005264 mg/L PBTK NA 50% Rat Human +DTXSID3032751 Css NA 0.02881 mg/L PBTK NA 95% Rat Human +DTXSID3032759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032759 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032759 Vd NA 1.103 L/kg 1compartment NA NA Human Human DTXSID3032759 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3032759 TK.Half.Life NA 6.07 hours 1compartment NA NA Human Human -DTXSID3032759 Css NA 0.7546 mg/L 3compartmentss NA 50% Human Human -DTXSID3032759 Css NA 3.939 mg/L 3compartmentss NA 95% Human Human -DTXSID3032759 Css NA 0.5196 mg/L PBTK NA 50% Human Human -DTXSID3032759 Css NA 2.497 mg/L PBTK NA 95% Human Human -DTXSID3032759 Clint NA 3.142 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032759 Fup NA 0.1876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032759 Vd NA 0.7811 L/kg 1compartment NA NA Rat Human +DTXSID3032759 TK.Half.Life NA 1.63 hours 1compartment NA NA Human Human +DTXSID3032759 Css NA 0.08562 mg/L 3compartmentss NA 50% Human Human +DTXSID3032759 Css NA 0.6435 mg/L 3compartmentss NA 95% Human Human +DTXSID3032759 Css NA 0.06211 mg/L PBTK NA 50% Human Human +DTXSID3032759 Css NA 0.4303 mg/L PBTK NA 95% Human Human +DTXSID3032759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032759 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032759 Vd NA 0.9116 L/kg 1compartment NA NA Rat Human DTXSID3032759 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032759 TK.Half.Life NA 2.699 hours 1compartment NA NA Rat Human -DTXSID3032759 Css NA 0.3634 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032759 Css NA 1.431 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032759 Css NA 0.238 mg/L PBTK NA 50% Rat Human -DTXSID3032759 Css NA 0.8483 mg/L PBTK NA 95% Rat Human -DTXSID3032832 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032832 Fup NA 0.4653 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3032832 Vd NA 0.7359 L/kg 1compartment NA NA Human Human -DTXSID3032832 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3032832 TK.Half.Life NA 10.23 hours 1compartment NA NA Human Human -DTXSID3032832 Css NA 1.402 mg/L 3compartmentss NA 50% Human Human -DTXSID3032832 Css NA 7.324 mg/L 3compartmentss NA 95% Human Human -DTXSID3032832 Css NA 1.161 mg/L PBTK NA 50% Human Human -DTXSID3032832 Css NA 4.869 mg/L PBTK NA 95% Human Human -DTXSID3032832 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032832 Fup NA 0.4653 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3032832 Vd NA 0.7396 L/kg 1compartment NA NA Rat Human +DTXSID3032759 TK.Half.Life NA 0.6987 hours 1compartment NA NA Rat Human +DTXSID3032759 Css NA 0.01104 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032759 Css NA 0.06007 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032759 Css NA 0.007901 mg/L PBTK NA 50% Rat Human +DTXSID3032759 Css NA 0.03965 mg/L PBTK NA 95% Rat Human +DTXSID3032832 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032832 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3032832 Vd NA 0.6229 L/kg 1compartment NA NA Human Human +DTXSID3032832 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3032832 TK.Half.Life NA 9.138 hours 1compartment NA NA Human Human +DTXSID3032832 Css NA 1.312 mg/L 3compartmentss NA 50% Human Human +DTXSID3032832 Css NA 6.437 mg/L 3compartmentss NA 95% Human Human +DTXSID3032832 Css NA 1.026 mg/L PBTK NA 50% Human Human +DTXSID3032832 Css NA 4.185 mg/L PBTK NA 95% Human Human +DTXSID3032832 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032832 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3032832 Vd NA 0.6297 L/kg 1compartment NA NA Rat Human DTXSID3032832 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3032832 TK.Half.Life NA 3.504 hours 1compartment NA NA Rat Human -DTXSID3032832 Css NA 0.3833 mg/L 3compartmentss NA 50% Rat Human -DTXSID3032832 Css NA 1.664 mg/L 3compartmentss NA 95% Rat Human -DTXSID3032832 Css NA 0.3062 mg/L PBTK NA 50% Rat Human -DTXSID3032832 Css NA 1.027 mg/L PBTK NA 95% Rat Human -DTXSID3033276 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033276 Fup NA 0.4858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033276 Vd NA 1.581 L/kg 1compartment NA NA Human Human -DTXSID3033276 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3033276 TK.Half.Life NA 22.18 hours 1compartment NA NA Human Human -DTXSID3033276 Css NA 1.334 mg/L 3compartmentss NA 50% Human Human -DTXSID3033276 Css NA 7.108 mg/L 3compartmentss NA 95% Human Human -DTXSID3033276 Css NA 1.184 mg/L PBTK NA 50% Human Human -DTXSID3033276 Css NA 4.795 mg/L PBTK NA 95% Human Human -DTXSID3033276 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033276 Fup NA 0.4858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033276 Vd NA 1.521 L/kg 1compartment NA NA Rat Human +DTXSID3032832 TK.Half.Life NA 3.149 hours 1compartment NA NA Rat Human +DTXSID3032832 Css NA 0.02434 mg/L 3compartmentss NA 50% Rat Human +DTXSID3032832 Css NA 0.1699 mg/L 3compartmentss NA 95% Rat Human +DTXSID3032832 Css NA 0.01837 mg/L PBTK NA 50% Rat Human +DTXSID3032832 Css NA 0.1096 mg/L PBTK NA 95% Rat Human +DTXSID30330241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30330241 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30330241 Vd NA 2.144 L/kg 1compartment NA NA Human Human +DTXSID30330241 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30330241 TK.Half.Life NA 2.643 hours 1compartment NA NA Human Human +DTXSID30330241 Css NA 0.06012 mg/L 3compartmentss NA 50% Human Human +DTXSID30330241 Css NA 0.5177 mg/L 3compartmentss NA 95% Human Human +DTXSID30330241 Css NA 0.05464 mg/L PBTK NA 50% Human Human +DTXSID30330241 Css NA 0.3912 mg/L PBTK NA 95% Human Human +DTXSID30330241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30330241 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30330241 Vd NA 2.141 L/kg 1compartment NA NA Rat Human +DTXSID30330241 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30330241 TK.Half.Life NA 1.456 hours 1compartment NA NA Rat Human +DTXSID30330241 Css NA 0.007623 mg/L 3compartmentss NA 50% Rat Human +DTXSID30330241 Css NA 0.0458 mg/L 3compartmentss NA 95% Rat Human +DTXSID30330241 Css NA 0.007001 mg/L PBTK NA 50% Rat Human +DTXSID30330241 Css NA 0.03641 mg/L PBTK NA 95% Rat Human +DTXSID3033276 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3033276 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3033276 Vd NA 2.091 L/kg 1compartment NA NA Human Human +DTXSID3033276 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3033276 TK.Half.Life NA 26.35 hours 1compartment NA NA Human Human +DTXSID3033276 Css NA 1.118 mg/L 3compartmentss NA 50% Human Human +DTXSID3033276 Css NA 7.964 mg/L 3compartmentss NA 95% Human Human +DTXSID3033276 Css NA 1.086 mg/L PBTK NA 50% Human Human +DTXSID3033276 Css NA 5.391 mg/L PBTK NA 95% Human Human +DTXSID3033276 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3033276 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3033276 Vd NA 1.968 L/kg 1compartment NA NA Rat Human DTXSID3033276 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3033276 TK.Half.Life NA 6.991 hours 1compartment NA NA Rat Human -DTXSID3033276 Css NA 0.3538 mg/L 3compartmentss NA 50% Rat Human -DTXSID3033276 Css NA 1.689 mg/L 3compartmentss NA 95% Rat Human -DTXSID3033276 Css NA 0.3064 mg/L PBTK NA 50% Rat Human -DTXSID3033276 Css NA 1.07 mg/L PBTK NA 95% Rat Human -DTXSID3033307 Clint NA 213.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033307 Fup NA 0.2634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033307 Vd NA 354.8 L/kg 1compartment NA NA Human Human -DTXSID3033307 Days.Css NA 253 Days PBTK NA NA Human Human -DTXSID3033307 TK.Half.Life NA 1054 hours 1compartment NA NA Human Human -DTXSID3033307 Css NA 0.004741 mg/L 3compartmentss NA 50% Human Human -DTXSID3033307 Css NA 0.03054 mg/L 3compartmentss NA 95% Human Human -DTXSID3033307 Css NA 0.2448 mg/L PBTK NA 50% Human Human -DTXSID3033307 Css NA 1.393 mg/L PBTK NA 95% Human Human -DTXSID3033307 Clint NA 213.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033307 Fup NA 0.2634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033307 Vd NA 318 L/kg 1compartment NA NA Rat Human -DTXSID3033307 Days.Css NA 172 Days PBTK NA NA Rat Human -DTXSID3033307 TK.Half.Life NA 159.2 hours 1compartment NA NA Rat Human -DTXSID3033307 Css NA 0.002422 mg/L 3compartmentss NA 50% Rat Human -DTXSID3033307 Css NA 0.01054 mg/L 3compartmentss NA 95% Rat Human -DTXSID3033307 Css NA 0.1318 mg/L PBTK NA 50% Rat Human -DTXSID3033307 Css NA 0.6097 mg/L PBTK NA 95% Rat Human -DTXSID3033511 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033511 Fup NA 0.5297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033511 Vd NA 0.5232 L/kg 1compartment NA NA Human Human -DTXSID3033511 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3033511 TK.Half.Life NA 6.388 hours 1compartment NA NA Human Human -DTXSID3033511 Css NA 1.428 mg/L 3compartmentss NA 50% Human Human -DTXSID3033511 Css NA 8.141 mg/L 3compartmentss NA 95% Human Human -DTXSID3033511 Css NA 1.076 mg/L PBTK NA 50% Human Human -DTXSID3033511 Css NA 5.031 mg/L PBTK NA 95% Human Human -DTXSID3033511 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033511 Fup NA 0.5297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033511 Vd NA 0.5505 L/kg 1compartment NA NA Rat Human -DTXSID3033511 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3033511 TK.Half.Life NA 2.291 hours 1compartment NA NA Rat Human -DTXSID3033511 Css NA 0.3759 mg/L 3compartmentss NA 50% Rat Human -DTXSID3033511 Css NA 1.985 mg/L 3compartmentss NA 95% Rat Human -DTXSID3033511 Css NA 0.2712 mg/L PBTK NA 50% Rat Human -DTXSID3033511 Css NA 1.157 mg/L PBTK NA 95% Rat Human +DTXSID3033276 TK.Half.Life NA 7.672 hours 1compartment NA NA Rat Human +DTXSID3033276 Css NA 0.06812 mg/L 3compartmentss NA 50% Rat Human +DTXSID3033276 Css NA 0.4659 mg/L 3compartmentss NA 95% Rat Human +DTXSID3033276 Css NA 0.06638 mg/L PBTK NA 50% Rat Human +DTXSID3033276 Css NA 0.3032 mg/L PBTK NA 95% Rat Human DTXSID3033519 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3033519 Fup NA 0.8659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033519 Vd NA 0.8956 L/kg 1compartment NA NA Human Human +DTXSID3033519 Vd NA 0.9011 L/kg 1compartment NA NA Human Human DTXSID3033519 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3033519 TK.Half.Life NA 6.749 hours 1compartment NA NA Human Human -DTXSID3033519 Css NA 0.9144 mg/L 3compartmentss NA 50% Human Human -DTXSID3033519 Css NA 5.615 mg/L 3compartmentss NA 95% Human Human -DTXSID3033519 Css NA 0.7825 mg/L PBTK NA 50% Human Human -DTXSID3033519 Css NA 3.733 mg/L PBTK NA 95% Human Human +DTXSID3033519 TK.Half.Life NA 6.796 hours 1compartment NA NA Human Human +DTXSID3033519 Css NA 0.7713 mg/L 3compartmentss NA 50% Human Human +DTXSID3033519 Css NA 4.803 mg/L 3compartmentss NA 95% Human Human +DTXSID3033519 Css NA 0.665 mg/L PBTK NA 50% Human Human +DTXSID3033519 Css NA 3.181 mg/L PBTK NA 95% Human Human DTXSID3033519 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3033519 Fup NA 0.8659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033519 Vd NA 0.9018 L/kg 1compartment NA NA Rat Human +DTXSID3033519 Vd NA 0.9057 L/kg 1compartment NA NA Rat Human DTXSID3033519 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3033519 TK.Half.Life NA 2.301 hours 1compartment NA NA Rat Human -DTXSID3033519 Css NA 0.2334 mg/L 3compartmentss NA 50% Rat Human -DTXSID3033519 Css NA 1.397 mg/L 3compartmentss NA 95% Rat Human -DTXSID3033519 Css NA 0.1949 mg/L PBTK NA 50% Rat Human -DTXSID3033519 Css NA 0.8491 mg/L PBTK NA 95% Rat Human -DTXSID3033983 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033983 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033983 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID3033983 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3033983 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID3033983 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID3033983 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID3033983 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID3033983 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID3033983 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033983 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033983 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human -DTXSID3033983 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3033983 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID3033983 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID3033983 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID3033983 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID3033983 Css NA 1.296 mg/L PBTK NA 95% Rat Human -DTXSID3033989 Clint NA 0.3453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033989 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3033989 Vd NA 0.1931 L/kg 1compartment NA NA Human Human -DTXSID3033989 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID3033989 TK.Half.Life NA 58.35 hours 1compartment NA NA Human Human -DTXSID3033989 Css NA 52.11 mg/L 3compartmentss NA 50% Human Human -DTXSID3033989 Css NA 330.7 mg/L 3compartmentss NA 95% Human Human -DTXSID3033989 Css NA 30.51 mg/L PBTK NA 50% Human Human -DTXSID3033989 Css NA 191.9 mg/L PBTK NA 95% Human Human -DTXSID3033989 Clint NA 0.3453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033989 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3033989 Vd NA 0.1876 L/kg 1compartment NA NA Rat Human -DTXSID3033989 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3033989 TK.Half.Life NA 23.78 hours 1compartment NA NA Rat Human -DTXSID3033989 Css NA 18.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID3033989 Css NA 105.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID3033989 Css NA 10.07 mg/L PBTK NA 50% Rat Human -DTXSID3033989 Css NA 57.12 mg/L PBTK NA 95% Rat Human -DTXSID3034113 Clint NA 2.539 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034113 Fup NA 0.1435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034113 Vd NA 2.263 L/kg 1compartment NA NA Human Human -DTXSID3034113 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3034113 TK.Half.Life NA 37.15 hours 1compartment NA NA Human Human -DTXSID3034113 Css NA 2.114 mg/L 3compartmentss NA 50% Human Human -DTXSID3034113 Css NA 10.45 mg/L 3compartmentss NA 95% Human Human -DTXSID3034113 Css NA 1.48 mg/L PBTK NA 50% Human Human -DTXSID3034113 Css NA 6.765 mg/L PBTK NA 95% Human Human -DTXSID3034113 Clint NA 2.539 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034113 Fup NA 0.1435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034113 Vd NA 1.72 L/kg 1compartment NA NA Rat Human -DTXSID3034113 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3034113 TK.Half.Life NA 9.732 hours 1compartment NA NA Rat Human -DTXSID3034113 Css NA 1.036 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034113 Css NA 3.597 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034113 Css NA 0.6904 mg/L PBTK NA 50% Rat Human -DTXSID3034113 Css NA 2.167 mg/L PBTK NA 95% Rat Human +DTXSID3033519 TK.Half.Life NA 2.31 hours 1compartment NA NA Rat Human +DTXSID3033519 Css NA 0.01436 mg/L 3compartmentss NA 50% Rat Human +DTXSID3033519 Css NA 0.1097 mg/L 3compartmentss NA 95% Rat Human +DTXSID3033519 Css NA 0.0118 mg/L PBTK NA 50% Rat Human +DTXSID3033519 Css NA 0.07307 mg/L PBTK NA 95% Rat Human +DTXSID30336723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30336723 Fup 0.0506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30336723 Vd NA 2.666 L/kg 1compartment NA NA Human Human +DTXSID30336723 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID30336723 TK.Half.Life NA 21.75 hours 1compartment NA NA Human Human +DTXSID30336723 Css NA 1.019 mg/L 3compartmentss NA 50% Human Human +DTXSID30336723 Css NA 6.865 mg/L 3compartmentss NA 95% Human Human +DTXSID30336723 Css NA 0.6888 mg/L PBTK NA 50% Human Human +DTXSID30336723 Css NA 4.461 mg/L PBTK NA 95% Human Human +DTXSID30336723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30336723 Fup 0.0506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30336723 Vd NA 1.998 L/kg 1compartment NA NA Rat Human +DTXSID30336723 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID30336723 TK.Half.Life NA 4.916 hours 1compartment NA NA Rat Human +DTXSID30336723 Css NA 0.1298 mg/L 3compartmentss NA 50% Rat Human +DTXSID30336723 Css NA 0.7366 mg/L 3compartmentss NA 95% Rat Human +DTXSID30336723 Css NA 0.08703 mg/L PBTK NA 50% Rat Human +DTXSID30336723 Css NA 0.4715 mg/L PBTK NA 95% Rat Human +DTXSID30338242 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30338242 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30338242 Vd NA 1.22 L/kg 1compartment NA NA Human Human +DTXSID30338242 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30338242 TK.Half.Life NA 1.168 hours 1compartment NA NA Human Human +DTXSID30338242 Css NA 0.03678 mg/L 3compartmentss NA 50% Human Human +DTXSID30338242 Css NA 0.3681 mg/L 3compartmentss NA 95% Human Human +DTXSID30338242 Css NA 0.03026 mg/L PBTK NA 50% Human Human +DTXSID30338242 Css NA 0.2577 mg/L PBTK NA 95% Human Human +DTXSID30338242 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30338242 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30338242 Vd NA 1.077 L/kg 1compartment NA NA Rat Human +DTXSID30338242 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30338242 TK.Half.Life NA 0.5074 hours 1compartment NA NA Rat Human +DTXSID30338242 Css NA 0.004504 mg/L 3compartmentss NA 50% Rat Human +DTXSID30338242 Css NA 0.03487 mg/L 3compartmentss NA 95% Rat Human +DTXSID30338242 Css NA 0.003799 mg/L PBTK NA 50% Rat Human +DTXSID30338242 Css NA 0.02397 mg/L PBTK NA 95% Rat Human +DTXSID3033989 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3033989 Fup 0.0572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3033989 Vd NA 0.2832 L/kg 1compartment NA NA Human Human +DTXSID3033989 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3033989 TK.Half.Life NA 1.11 hours 1compartment NA NA Human Human +DTXSID3033989 Css NA 0.538 mg/L 3compartmentss NA 50% Human Human +DTXSID3033989 Css NA 4.205 mg/L 3compartmentss NA 95% Human Human +DTXSID3033989 Css NA 0.3259 mg/L PBTK NA 50% Human Human +DTXSID3033989 Css NA 2.505 mg/L PBTK NA 95% Human Human +DTXSID3033989 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3033989 Fup 0.0572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3033989 Vd NA 0.2717 L/kg 1compartment NA NA Rat Human +DTXSID3033989 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3033989 TK.Half.Life NA 0.6627 hours 1compartment NA NA Rat Human +DTXSID3033989 Css NA 0.06972 mg/L 3compartmentss NA 50% Rat Human +DTXSID3033989 Css NA 0.4458 mg/L 3compartmentss NA 95% Rat Human +DTXSID3033989 Css NA 0.04114 mg/L PBTK NA 50% Rat Human +DTXSID3033989 Css NA 0.2541 mg/L PBTK NA 95% Rat Human +DTXSID3034113 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034113 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034113 Vd NA 1.689 L/kg 1compartment NA NA Human Human +DTXSID3034113 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3034113 TK.Half.Life NA 4.542 hours 1compartment NA NA Human Human +DTXSID3034113 Css NA 0.2749 mg/L 3compartmentss NA 50% Human Human +DTXSID3034113 Css NA 2.051 mg/L 3compartmentss NA 95% Human Human +DTXSID3034113 Css NA 0.1856 mg/L PBTK NA 50% Human Human +DTXSID3034113 Css NA 1.308 mg/L PBTK NA 95% Human Human +DTXSID3034113 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034113 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034113 Vd NA 1.292 L/kg 1compartment NA NA Rat Human +DTXSID3034113 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3034113 TK.Half.Life NA 1.674 hours 1compartment NA NA Rat Human +DTXSID3034113 Css NA 0.03528 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034113 Css NA 0.2089 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034113 Css NA 0.02336 mg/L PBTK NA 50% Rat Human +DTXSID3034113 Css NA 0.1299 mg/L PBTK NA 95% Rat Human DTXSID3034165 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3034165 Fup 0.167 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3034165 Vd NA 0.6456 L/kg 1compartment NA NA Human Human -DTXSID3034165 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3034165 TK.Half.Life NA 25.06 hours 1compartment NA NA Human Human -DTXSID3034165 Css NA 3.939 mg/L 3compartmentss NA 50% Human Human -DTXSID3034165 Css NA 13.6 mg/L 3compartmentss NA 95% Human Human -DTXSID3034165 Css NA 2.977 mg/L PBTK NA 50% Human Human -DTXSID3034165 Css NA 9.006 mg/L PBTK NA 95% Human Human +DTXSID3034165 Vd NA 0.4377 L/kg 1compartment NA NA Human Human +DTXSID3034165 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3034165 TK.Half.Life NA 16.96 hours 1compartment NA NA Human Human +DTXSID3034165 Css NA 4.22 mg/L 3compartmentss NA 50% Human Human +DTXSID3034165 Css NA 13.95 mg/L 3compartmentss NA 95% Human Human +DTXSID3034165 Css NA 2.872 mg/L PBTK NA 50% Human Human +DTXSID3034165 Css NA 8.719 mg/L PBTK NA 95% Human Human DTXSID3034165 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3034165 Fup 0.167 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3034165 Vd NA 0.6364 L/kg 1compartment NA NA Rat Human +DTXSID3034165 Vd NA 0.4357 L/kg 1compartment NA NA Rat Human DTXSID3034165 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3034165 TK.Half.Life NA 8.407 hours 1compartment NA NA Rat Human -DTXSID3034165 Css NA 1.068 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034165 Css NA 3.116 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034165 Css NA 0.7762 mg/L PBTK NA 50% Rat Human -DTXSID3034165 Css NA 1.918 mg/L PBTK NA 95% Rat Human +DTXSID3034165 TK.Half.Life NA 5.752 hours 1compartment NA NA Rat Human +DTXSID3034165 Css NA 0.2719 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034165 Css NA 0.7356 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034165 Css NA 0.1823 mg/L PBTK NA 50% Rat Human +DTXSID3034165 Css NA 0.4449 mg/L PBTK NA 95% Rat Human DTXSID3034402 Clint 100.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3034402 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034402 Vd NA 2.852 L/kg 1compartment NA NA Human Human +DTXSID3034402 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034402 Vd NA 2.515 L/kg 1compartment NA NA Human Human DTXSID3034402 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3034402 TK.Half.Life NA 10.76 hours 1compartment NA NA Human Human -DTXSID3034402 Css NA 0.4122 mg/L 3compartmentss NA 50% Human Human -DTXSID3034402 Css NA 2.833 mg/L 3compartmentss NA 95% Human Human -DTXSID3034402 Css NA 0.2798 mg/L PBTK NA 50% Human Human -DTXSID3034402 Css NA 1.871 mg/L PBTK NA 95% Human Human +DTXSID3034402 TK.Half.Life NA 11.12 hours 1compartment NA NA Human Human +DTXSID3034402 Css NA 0.5307 mg/L 3compartmentss NA 50% Human Human +DTXSID3034402 Css NA 4.092 mg/L 3compartmentss NA 95% Human Human +DTXSID3034402 Css NA 0.3512 mg/L PBTK NA 50% Human Human +DTXSID3034402 Css NA 2.571 mg/L PBTK NA 95% Human Human DTXSID3034402 Clint 100.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID3034402 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034402 Vd NA 2.134 L/kg 1compartment NA NA Rat Human +DTXSID3034402 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034402 Vd NA 1.874 L/kg 1compartment NA NA Rat Human DTXSID3034402 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3034402 TK.Half.Life NA 2.295 hours 1compartment NA NA Rat Human -DTXSID3034402 Css NA 0.2306 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034402 Css NA 1.323 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034402 Css NA 0.149 mg/L PBTK NA 50% Rat Human -DTXSID3034402 Css NA 0.8103 mg/L PBTK NA 95% Rat Human +DTXSID3034402 TK.Half.Life NA 2.85 hours 1compartment NA NA Rat Human +DTXSID3034402 Css NA 0.0696 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034402 Css NA 0.4679 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034402 Css NA 0.04494 mg/L PBTK NA 50% Rat Human +DTXSID3034402 Css NA 0.2917 mg/L PBTK NA 95% Rat Human DTXSID3034456 Clint 28.17 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3034456 Fup NA 0.0328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034456 Vd NA 2.956 L/kg 1compartment NA NA Human Human +DTXSID3034456 Fup 0.0267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034456 Vd NA 2.916 L/kg 1compartment NA NA Human Human DTXSID3034456 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3034456 TK.Half.Life NA 35.77 hours 1compartment NA NA Human Human -DTXSID3034456 Css NA 1.506 mg/L 3compartmentss NA 50% Human Human -DTXSID3034456 Css NA 9.886 mg/L 3compartmentss NA 95% Human Human -DTXSID3034456 Css NA 1.034 mg/L PBTK NA 50% Human Human -DTXSID3034456 Css NA 6.515 mg/L PBTK NA 95% Human Human +DTXSID3034456 TK.Half.Life NA 35.97 hours 1compartment NA NA Human Human +DTXSID3034456 Css NA 1.527 mg/L 3compartmentss NA 50% Human Human +DTXSID3034456 Css NA 10.81 mg/L 3compartmentss NA 95% Human Human +DTXSID3034456 Css NA 1.046 mg/L PBTK NA 50% Human Human +DTXSID3034456 Css NA 7.097 mg/L PBTK NA 95% Human Human DTXSID3034456 Clint 28.17 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID3034456 Fup NA 0.0328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034456 Vd NA 2.215 L/kg 1compartment NA NA Rat Human +DTXSID3034456 Fup 0.0267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034456 Vd NA 2.184 L/kg 1compartment NA NA Rat Human DTXSID3034456 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3034456 TK.Half.Life NA 6.15 hours 1compartment NA NA Rat Human -DTXSID3034456 Css NA 0.8496 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034456 Css NA 4.526 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034456 Css NA 0.5555 mg/L PBTK NA 50% Rat Human -DTXSID3034456 Css NA 2.896 mg/L PBTK NA 95% Rat Human -DTXSID3034458 Clint NA 3.746 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034458 Fup NA 0.0395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034458 Vd NA 0.8614 L/kg 1compartment NA NA Human Human -DTXSID3034458 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3034458 TK.Half.Life NA 19.79 hours 1compartment NA NA Human Human -DTXSID3034458 Css NA 3.878 mg/L 3compartmentss NA 50% Human Human -DTXSID3034458 Css NA 29.41 mg/L 3compartmentss NA 95% Human Human -DTXSID3034458 Css NA 2.443 mg/L PBTK NA 50% Human Human -DTXSID3034458 Css NA 17.65 mg/L PBTK NA 95% Human Human -DTXSID3034458 Clint NA 3.746 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034458 Fup NA 0.0395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034458 Vd NA 0.6653 L/kg 1compartment NA NA Rat Human -DTXSID3034458 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3034458 TK.Half.Life NA 8.634 hours 1compartment NA NA Rat Human -DTXSID3034458 Css NA 2.007 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034458 Css NA 11.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034458 Css NA 1.182 mg/L PBTK NA 50% Rat Human -DTXSID3034458 Css NA 6.431 mg/L PBTK NA 95% Rat Human -DTXSID3034531 Clint NA 95.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034531 Fup NA 0.1151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034531 Vd NA 0.4127 L/kg 1compartment NA NA Human Human +DTXSID3034456 TK.Half.Life NA 6.43 hours 1compartment NA NA Rat Human +DTXSID3034456 Css NA 0.1988 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034456 Css NA 1.173 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034456 Css NA 0.1343 mg/L PBTK NA 50% Rat Human +DTXSID3034456 Css NA 0.7607 mg/L PBTK NA 95% Rat Human +DTXSID3034458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034458 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034458 Vd NA 2.988 L/kg 1compartment NA NA Human Human +DTXSID3034458 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3034458 TK.Half.Life NA 33.86 hours 1compartment NA NA Human Human +DTXSID3034458 Css NA 1.318 mg/L 3compartmentss NA 50% Human Human +DTXSID3034458 Css NA 8.588 mg/L 3compartmentss NA 95% Human Human +DTXSID3034458 Css NA 0.9124 mg/L PBTK NA 50% Human Human +DTXSID3034458 Css NA 5.79 mg/L PBTK NA 95% Human Human +DTXSID3034458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034458 Fup 0.072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034458 Vd NA 2.242 L/kg 1compartment NA NA Rat Human +DTXSID3034458 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3034458 TK.Half.Life NA 5.682 hours 1compartment NA NA Rat Human +DTXSID3034458 Css NA 0.171 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034458 Css NA 0.9474 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034458 Css NA 0.117 mg/L PBTK NA 50% Rat Human +DTXSID3034458 Css NA 0.6365 mg/L PBTK NA 95% Rat Human +DTXSID3034531 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034531 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034531 Vd NA 0.5504 L/kg 1compartment NA NA Human Human DTXSID3034531 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3034531 TK.Half.Life NA 0.5063 hours 1compartment NA NA Human Human -DTXSID3034531 Css NA 0.0592 mg/L 3compartmentss NA 50% Human Human -DTXSID3034531 Css NA 0.4911 mg/L 3compartmentss NA 95% Human Human -DTXSID3034531 Css NA 0.037 mg/L PBTK NA 50% Human Human -DTXSID3034531 Css NA 0.2992 mg/L PBTK NA 95% Human Human -DTXSID3034531 Clint NA 95.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034531 Fup NA 0.1151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034531 Vd NA 0.3814 L/kg 1compartment NA NA Rat Human +DTXSID3034531 TK.Half.Life NA 1.93 hours 1compartment NA NA Human Human +DTXSID3034531 Css NA 0.3497 mg/L 3compartmentss NA 50% Human Human +DTXSID3034531 Css NA 2.034 mg/L 3compartmentss NA 95% Human Human +DTXSID3034531 Css NA 0.236 mg/L PBTK NA 50% Human Human +DTXSID3034531 Css NA 1.295 mg/L PBTK NA 95% Human Human +DTXSID3034531 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034531 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034531 Vd NA 0.5085 L/kg 1compartment NA NA Rat Human DTXSID3034531 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3034531 TK.Half.Life NA 0.2365 hours 1compartment NA NA Rat Human -DTXSID3034531 Css NA 0.0337 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034531 Css NA 0.2194 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034531 Css NA 0.01981 mg/L PBTK NA 50% Rat Human -DTXSID3034531 Css NA 0.1261 mg/L PBTK NA 95% Rat Human -DTXSID3034583 Clint NA 22.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034583 Fup NA 0.0491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034583 Vd NA 2.031 L/kg 1compartment NA NA Human Human -DTXSID3034583 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3034583 TK.Half.Life NA 11.15 hours 1compartment NA NA Human Human -DTXSID3034583 Css NA 0.7278 mg/L 3compartmentss NA 50% Human Human -DTXSID3034583 Css NA 5.452 mg/L 3compartmentss NA 95% Human Human -DTXSID3034583 Css NA 0.4798 mg/L PBTK NA 50% Human Human -DTXSID3034583 Css NA 3.452 mg/L PBTK NA 95% Human Human -DTXSID3034583 Clint NA 22.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034583 Fup NA 0.0491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034583 Vd NA 1.521 L/kg 1compartment NA NA Rat Human +DTXSID3034531 TK.Half.Life NA 1.039 hours 1compartment NA NA Rat Human +DTXSID3034531 Css NA 0.04172 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034531 Css NA 0.1766 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034531 Css NA 0.02766 mg/L PBTK NA 50% Rat Human +DTXSID3034531 Css NA 0.1089 mg/L PBTK NA 95% Rat Human +DTXSID3034583 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034583 Fup 0.0203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034583 Vd NA 1.926 L/kg 1compartment NA NA Human Human +DTXSID3034583 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3034583 TK.Half.Life NA 19.06 hours 1compartment NA NA Human Human +DTXSID3034583 Css NA 1.492 mg/L 3compartmentss NA 50% Human Human +DTXSID3034583 Css NA 12.03 mg/L 3compartmentss NA 95% Human Human +DTXSID3034583 Css NA 0.9508 mg/L PBTK NA 50% Human Human +DTXSID3034583 Css NA 7.462 mg/L PBTK NA 95% Human Human +DTXSID3034583 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034583 Fup 0.0203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034583 Vd NA 1.43 L/kg 1compartment NA NA Rat Human DTXSID3034583 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3034583 TK.Half.Life NA 3.591 hours 1compartment NA NA Rat Human -DTXSID3034583 Css NA 0.4099 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034583 Css NA 2.342 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034583 Css NA 0.2548 mg/L PBTK NA 50% Rat Human -DTXSID3034583 Css NA 1.409 mg/L PBTK NA 95% Rat Human +DTXSID3034583 TK.Half.Life NA 6.324 hours 1compartment NA NA Rat Human +DTXSID3034583 Css NA 0.1898 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034583 Css NA 1.293 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034583 Css NA 0.1191 mg/L PBTK NA 50% Rat Human +DTXSID3034583 Css NA 0.7702 mg/L PBTK NA 95% Rat Human DTXSID3034612 Clint 401 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3034612 Fup 0.00862 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3034612 Vd NA 2.412 L/kg 1compartment NA NA Human Human DTXSID3034612 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3034612 TK.Half.Life NA 4.387 hours 1compartment NA NA Human Human -DTXSID3034612 Css NA 0.1614 mg/L 3compartmentss NA 50% Human Human -DTXSID3034612 Css NA 1.326 mg/L 3compartmentss NA 95% Human Human -DTXSID3034612 Css NA 0.1047 mg/L PBTK NA 50% Human Human -DTXSID3034612 Css NA 0.8238 mg/L PBTK NA 95% Human Human +DTXSID3034612 Css NA 0.1542 mg/L 3compartmentss NA 50% Human Human +DTXSID3034612 Css NA 1.378 mg/L 3compartmentss NA 95% Human Human +DTXSID3034612 Css NA 0.1006 mg/L PBTK NA 50% Human Human +DTXSID3034612 Css NA 0.8496 mg/L PBTK NA 95% Human Human DTXSID3034612 Clint 401 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3034612 Fup 0.00862 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3034612 Vd NA 1.794 L/kg 1compartment NA NA Rat Human DTXSID3034612 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3034612 TK.Half.Life NA 1.271 hours 1compartment NA NA Rat Human -DTXSID3034612 Css NA 0.09215 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034612 Css NA 0.6398 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034612 Css NA 0.05644 mg/L PBTK NA 50% Rat Human -DTXSID3034612 Css NA 0.3773 mg/L PBTK NA 95% Rat Human -DTXSID3034614 Clint NA 3.659 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034614 Fup NA 0.0521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034614 Vd NA 0.2795 L/kg 1compartment NA NA Human Human -DTXSID3034614 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3034614 TK.Half.Life NA 5.112 hours 1compartment NA NA Human Human -DTXSID3034614 Css NA 3.107 mg/L 3compartmentss NA 50% Human Human -DTXSID3034614 Css NA 19.7 mg/L 3compartmentss NA 95% Human Human -DTXSID3034614 Css NA 1.893 mg/L PBTK NA 50% Human Human -DTXSID3034614 Css NA 11.72 mg/L PBTK NA 95% Human Human -DTXSID3034614 Clint NA 3.659 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034614 Fup NA 0.0521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034614 Vd NA 0.2741 L/kg 1compartment NA NA Rat Human -DTXSID3034614 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3034614 TK.Half.Life NA 3.007 hours 1compartment NA NA Rat Human -DTXSID3034614 Css NA 1.587 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034614 Css NA 7.718 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034614 Css NA 0.9055 mg/L PBTK NA 50% Rat Human -DTXSID3034614 Css NA 4.22 mg/L PBTK NA 95% Rat Human +DTXSID3034612 Css NA 0.02034 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034612 Css NA 0.1484 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034612 Css NA 0.0129 mg/L PBTK NA 50% Rat Human +DTXSID3034612 Css NA 0.09064 mg/L PBTK NA 95% Rat Human +DTXSID3034614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034614 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034614 Vd NA 408.2 L/kg 1compartment NA NA Human Human +DTXSID3034614 Days.Css NA 201 Days PBTK NA NA Human Human +DTXSID3034614 TK.Half.Life NA 855.3 hours 1compartment NA NA Human Human +DTXSID3034614 Css NA 0.002826 mg/L 3compartmentss NA 50% Human Human +DTXSID3034614 Css NA 0.03228 mg/L 3compartmentss NA 95% Human Human +DTXSID3034614 Css NA 0.1701 mg/L PBTK NA 50% Human Human +DTXSID3034614 Css NA 1.072 mg/L PBTK NA 95% Human Human +DTXSID3034614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034614 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034614 Vd NA 379.4 L/kg 1compartment NA NA Rat Human +DTXSID3034614 Days.Css NA 140 Days PBTK NA NA Rat Human +DTXSID3034614 TK.Half.Life NA 310.1 hours 1compartment NA NA Rat Human +DTXSID3034614 Css NA 0.0001201 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034614 Css NA 0.001519 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034614 Css NA 0.007956 mg/L PBTK NA 50% Rat Human +DTXSID3034614 Css NA 0.05657 mg/L PBTK NA 95% Rat Human DTXSID3034618 Clint 375 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3034618 Fup 0.769 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3034618 Vd NA 3.009 L/kg 1compartment NA NA Human Human +DTXSID3034618 Vd NA 3.047 L/kg 1compartment NA NA Human Human DTXSID3034618 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3034618 TK.Half.Life NA 2.419 hours 1compartment NA NA Human Human -DTXSID3034618 Css NA 0.01022 mg/L 3compartmentss NA 50% Human Human -DTXSID3034618 Css NA 0.06329 mg/L 3compartmentss NA 95% Human Human -DTXSID3034618 Css NA 0.007916 mg/L PBTK NA 50% Human Human -DTXSID3034618 Css NA 0.04661 mg/L PBTK NA 95% Human Human +DTXSID3034618 TK.Half.Life NA 2.567 hours 1compartment NA NA Human Human +DTXSID3034618 Css NA 0.01046 mg/L 3compartmentss NA 50% Human Human +DTXSID3034618 Css NA 0.08093 mg/L 3compartmentss NA 95% Human Human +DTXSID3034618 Css NA 0.007985 mg/L PBTK NA 50% Human Human +DTXSID3034618 Css NA 0.05866 mg/L PBTK NA 95% Human Human DTXSID3034618 Clint 375 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3034618 Fup 0.769 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3034618 Vd NA 2.299 L/kg 1compartment NA NA Rat Human +DTXSID3034618 Vd NA 2.32 L/kg 1compartment NA NA Rat Human DTXSID3034618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3034618 TK.Half.Life NA 0.745 hours 1compartment NA NA Rat Human -DTXSID3034618 Css NA 0.005536 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034618 Css NA 0.02986 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034618 Css NA 0.004169 mg/L PBTK NA 50% Rat Human -DTXSID3034618 Css NA 0.02176 mg/L PBTK NA 95% Rat Human -DTXSID3034662 Clint NA 6.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034662 Fup NA 0.0555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034662 Vd NA 2.316 L/kg 1compartment NA NA Human Human -DTXSID3034662 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3034662 TK.Half.Life NA 19.05 hours 1compartment NA NA Human Human -DTXSID3034662 Css NA 1.101 mg/L 3compartmentss NA 50% Human Human -DTXSID3034662 Css NA 7.861 mg/L 3compartmentss NA 95% Human Human -DTXSID3034662 Css NA 0.8096 mg/L PBTK NA 50% Human Human -DTXSID3034662 Css NA 5.209 mg/L PBTK NA 95% Human Human -DTXSID3034662 Clint NA 6.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034662 Fup NA 0.0555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034662 Vd NA 2.009 L/kg 1compartment NA NA Rat Human -DTXSID3034662 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3034662 TK.Half.Life NA 8.373 hours 1compartment NA NA Rat Human -DTXSID3034662 Css NA 0.58 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034662 Css NA 3.325 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034662 Css NA 0.4082 mg/L PBTK NA 50% Rat Human -DTXSID3034662 Css NA 2.049 mg/L PBTK NA 95% Rat Human +DTXSID3034618 TK.Half.Life NA 0.7791 hours 1compartment NA NA Rat Human +DTXSID3034618 Css NA 0.001388 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034618 Css NA 0.009319 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034618 Css NA 0.00107 mg/L PBTK NA 50% Rat Human +DTXSID3034618 Css NA 0.006951 mg/L PBTK NA 95% Rat Human +DTXSID3034662 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034662 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034662 Vd NA 0.7017 L/kg 1compartment NA NA Human Human +DTXSID3034662 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3034662 TK.Half.Life NA 2.276 hours 1compartment NA NA Human Human +DTXSID3034662 Css NA 0.3088 mg/L 3compartmentss NA 50% Human Human +DTXSID3034662 Css NA 1.889 mg/L 3compartmentss NA 95% Human Human +DTXSID3034662 Css NA 0.2164 mg/L PBTK NA 50% Human Human +DTXSID3034662 Css NA 1.229 mg/L PBTK NA 95% Human Human +DTXSID3034662 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034662 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034662 Vd NA 0.7092 L/kg 1compartment NA NA Rat Human +DTXSID3034662 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3034662 TK.Half.Life NA 1.348 hours 1compartment NA NA Rat Human +DTXSID3034662 Css NA 0.03674 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034662 Css NA 0.1654 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034662 Css NA 0.0255 mg/L PBTK NA 50% Rat Human +DTXSID3034662 Css NA 0.1048 mg/L PBTK NA 95% Rat Human DTXSID3034664 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3034664 Fup 0.4548 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID3034664 Vd NA 0.7369 L/kg 1compartment NA NA Human Human DTXSID3034664 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID3034664 TK.Half.Life NA 10.66 hours 1compartment NA NA Human Human -DTXSID3034664 Css NA 1.565 mg/L 3compartmentss NA 50% Human Human -DTXSID3034664 Css NA 7.361 mg/L 3compartmentss NA 95% Human Human -DTXSID3034664 Css NA 1.208 mg/L PBTK NA 50% Human Human -DTXSID3034664 Css NA 4.762 mg/L PBTK NA 95% Human Human +DTXSID3034664 Css NA 0.8598 mg/L 3compartmentss NA 50% Human Human +DTXSID3034664 Css NA 4.187 mg/L 3compartmentss NA 95% Human Human +DTXSID3034664 Css NA 0.6672 mg/L PBTK NA 50% Human Human +DTXSID3034664 Css NA 2.694 mg/L PBTK NA 95% Human Human DTXSID3034664 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3034664 Fup 0.4548 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID3034664 Vd NA 0.7068 L/kg 1compartment NA NA Rat Human DTXSID3034664 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3034664 TK.Half.Life NA 3.44 hours 1compartment NA NA Rat Human -DTXSID3034664 Css NA 0.4204 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034664 Css NA 1.767 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034664 Css NA 0.3126 mg/L PBTK NA 50% Rat Human -DTXSID3034664 Css NA 1.06 mg/L PBTK NA 95% Rat Human -DTXSID3034872 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3034872 Fup 0.4273 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID3034872 Vd NA 0.9117 L/kg 1compartment NA NA Human Human -DTXSID3034872 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3034872 TK.Half.Life NA 14.44 hours 1compartment NA NA Human Human -DTXSID3034872 Css NA 1.478 mg/L 3compartmentss NA 50% Human Human -DTXSID3034872 Css NA 7.301 mg/L 3compartmentss NA 95% Human Human -DTXSID3034872 Css NA 1.317 mg/L PBTK NA 50% Human Human -DTXSID3034872 Css NA 5.096 mg/L PBTK NA 95% Human Human -DTXSID3034872 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID3034872 Fup 0.4889 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID3034872 Vd NA 0.8997 L/kg 1compartment NA NA Rat Rat -DTXSID3034872 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID3034872 TK.Half.Life NA 4.109 hours 1compartment NA NA Rat Rat -DTXSID3034872 Css NA 0.3507 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3034872 Css NA 1.638 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3034872 Css NA 0.3057 mg/L PBTK NA 50% Rat Rat -DTXSID3034872 Css NA 1.044 mg/L PBTK NA 95% Rat Rat -DTXSID3034903 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034903 Fup NA 0.2766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034903 Vd NA 0.3395 L/kg 1compartment NA NA Human Human -DTXSID3034903 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3034903 TK.Half.Life NA 7.942 hours 1compartment NA NA Human Human -DTXSID3034903 Css NA 2.883 mg/L 3compartmentss NA 50% Human Human -DTXSID3034903 Css NA 11.05 mg/L 3compartmentss NA 95% Human Human -DTXSID3034903 Css NA 1.926 mg/L PBTK NA 50% Human Human -DTXSID3034903 Css NA 6.75 mg/L PBTK NA 95% Human Human -DTXSID3034903 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034903 Fup NA 0.2766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034903 Vd NA 0.3623 L/kg 1compartment NA NA Rat Human -DTXSID3034903 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3034903 TK.Half.Life NA 2.888 hours 1compartment NA NA Rat Human -DTXSID3034903 Css NA 0.8006 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034903 Css NA 2.544 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034903 Css NA 0.5034 mg/L PBTK NA 50% Rat Human -DTXSID3034903 Css NA 1.452 mg/L PBTK NA 95% Rat Human -DTXSID3034957 Clint NA 0.2127 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034957 Fup NA 0.5093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3034957 Vd NA 0.8466 L/kg 1compartment NA NA Human Human -DTXSID3034957 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3034957 TK.Half.Life NA 8.171 hours 1compartment NA NA Human Human -DTXSID3034957 Css NA 1.009 mg/L 3compartmentss NA 50% Human Human -DTXSID3034957 Css NA 5.491 mg/L 3compartmentss NA 95% Human Human -DTXSID3034957 Css NA 0.8058 mg/L PBTK NA 50% Human Human -DTXSID3034957 Css NA 3.487 mg/L PBTK NA 95% Human Human -DTXSID3034957 Clint NA 0.2127 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034957 Fup NA 0.5093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3034957 Vd NA 0.803 L/kg 1compartment NA NA Rat Human -DTXSID3034957 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3034957 TK.Half.Life NA 2.986 hours 1compartment NA NA Rat Human -DTXSID3034957 Css NA 0.3226 mg/L 3compartmentss NA 50% Rat Human -DTXSID3034957 Css NA 1.572 mg/L 3compartmentss NA 95% Rat Human -DTXSID3034957 Css NA 0.2479 mg/L PBTK NA 50% Rat Human -DTXSID3034957 Css NA 0.9457 mg/L PBTK NA 95% Rat Human -DTXSID3035214 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3035214 Fup NA 0.4295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3035214 Vd NA 2.118 L/kg 1compartment NA NA Human Human -DTXSID3035214 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID3035214 TK.Half.Life NA 55.9 hours 1compartment NA NA Human Human -DTXSID3035214 Css NA 2.709 mg/L 3compartmentss NA 50% Human Human -DTXSID3035214 Css NA 10.2 mg/L 3compartmentss NA 95% Human Human -DTXSID3035214 Css NA 2.184 mg/L PBTK NA 50% Human Human -DTXSID3035214 Css NA 7.043 mg/L PBTK NA 95% Human Human -DTXSID3035214 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3035214 Fup NA 0.4295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3035214 Vd NA 1.682 L/kg 1compartment NA NA Rat Human -DTXSID3035214 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3035214 TK.Half.Life NA 10.18 hours 1compartment NA NA Rat Human -DTXSID3035214 Css NA 0.7316 mg/L 3compartmentss NA 50% Rat Human -DTXSID3035214 Css NA 2.285 mg/L 3compartmentss NA 95% Rat Human -DTXSID3035214 Css NA 0.5723 mg/L PBTK NA 50% Rat Human -DTXSID3035214 Css NA 1.452 mg/L PBTK NA 95% Rat Human -DTXSID3035266 Clint NA 2.415 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3035266 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3035266 Vd NA 5.664 L/kg 1compartment NA NA Human Human -DTXSID3035266 Days.Css NA 382 Days PBTK NA NA Human Human -DTXSID3035266 TK.Half.Life NA 1491 hours 1compartment NA NA Human Human -DTXSID3035266 Css NA 25.62 mg/L 3compartmentss NA 50% Human Human -DTXSID3035266 Css NA 139.4 mg/L 3compartmentss NA 95% Human Human -DTXSID3035266 Css NA 21.92 mg/L PBTK NA 50% Human Human -DTXSID3035266 Css NA 117.2 mg/L PBTK NA 95% Human Human -DTXSID3035266 Clint NA 2.415 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3035266 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3035266 Vd NA 4.349 L/kg 1compartment NA NA Rat Human -DTXSID3035266 Days.Css NA 210 Days PBTK NA NA Rat Human -DTXSID3035266 TK.Half.Life NA 195.4 hours 1compartment NA NA Rat Human -DTXSID3035266 Css NA 14.01 mg/L 3compartmentss NA 50% Rat Human -DTXSID3035266 Css NA 56.66 mg/L 3compartmentss NA 95% Rat Human -DTXSID3035266 Css NA 11.68 mg/L PBTK NA 50% Rat Human -DTXSID3035266 Css NA 47.41 mg/L PBTK NA 95% Rat Human -DTXSID3036286 Clint NA 6.217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3036286 Fup NA 0.3247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3036286 Vd NA 1.467 L/kg 1compartment NA NA Human Human -DTXSID3036286 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3036286 TK.Half.Life NA 3.923 hours 1compartment NA NA Human Human -DTXSID3036286 Css NA 0.2372 mg/L 3compartmentss NA 50% Human Human -DTXSID3036286 Css NA 1.477 mg/L 3compartmentss NA 95% Human Human -DTXSID3036286 Css NA 0.1824 mg/L PBTK NA 50% Human Human -DTXSID3036286 Css NA 1.038 mg/L PBTK NA 95% Human Human -DTXSID3036286 Clint NA 6.217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3036286 Fup NA 0.3247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3036286 Vd NA 1.197 L/kg 1compartment NA NA Rat Human -DTXSID3036286 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3036286 TK.Half.Life NA 1.615 hours 1compartment NA NA Rat Human -DTXSID3036286 Css NA 0.1204 mg/L 3compartmentss NA 50% Rat Human -DTXSID3036286 Css NA 0.5457 mg/L 3compartmentss NA 95% Rat Human -DTXSID3036286 Css NA 0.08924 mg/L PBTK NA 50% Rat Human -DTXSID3036286 Css NA 0.3548 mg/L PBTK NA 95% Rat Human -DTXSID3036288 Clint NA 15.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3036288 Fup NA 0.0084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3036288 Vd NA 495.3 L/kg 1compartment NA NA Human Human -DTXSID3036288 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID3036288 TK.Half.Life NA 21010 hours 1compartment NA NA Human Human -DTXSID3036288 Css NA 0.04812 mg/L 3compartmentss NA 50% Human Human -DTXSID3036288 Css NA 0.2921 mg/L 3compartmentss NA 95% Human Human -DTXSID3036288 Css NA 3.534 mg/L PBTK NA 50% Human Human -DTXSID3036288 Css NA 19.19 mg/L PBTK NA 95% Human Human -DTXSID3036288 Clint NA 15.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3036288 Fup NA 0.0084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3036288 Vd NA 447.5 L/kg 1compartment NA NA Rat Human -DTXSID3036288 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID3036288 TK.Half.Life NA 3337 hours 1compartment NA NA Rat Human -DTXSID3036288 Css NA 0.02423 mg/L 3compartmentss NA 50% Rat Human -DTXSID3036288 Css NA 0.1049 mg/L 3compartmentss NA 95% Rat Human -DTXSID3036288 Css NA 1.909 mg/L PBTK NA 50% Rat Human -DTXSID3036288 Css NA 8.59 mg/L PBTK NA 95% Rat Human +DTXSID3034664 Css NA 0.00457 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034664 Css NA 0.02423 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034664 Css NA 0.003434 mg/L PBTK NA 50% Rat Human +DTXSID3034664 Css NA 0.0152 mg/L PBTK NA 95% Rat Human +DTXSID3034799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034799 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034799 Vd NA 0.8283 L/kg 1compartment NA NA Human Human +DTXSID3034799 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3034799 TK.Half.Life NA 0.921 hours 1compartment NA NA Human Human +DTXSID3034799 Css NA 0.04848 mg/L 3compartmentss NA 50% Human Human +DTXSID3034799 Css NA 0.3939 mg/L 3compartmentss NA 95% Human Human +DTXSID3034799 Css NA 0.0371 mg/L PBTK NA 50% Human Human +DTXSID3034799 Css NA 0.277 mg/L PBTK NA 95% Human Human +DTXSID3034799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034799 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034799 Vd NA 0.7642 L/kg 1compartment NA NA Rat Human +DTXSID3034799 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3034799 TK.Half.Life NA 0.4351 hours 1compartment NA NA Rat Human +DTXSID3034799 Css NA 0.005988 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034799 Css NA 0.0384 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034799 Css NA 0.004596 mg/L PBTK NA 50% Rat Human +DTXSID3034799 Css NA 0.0258 mg/L PBTK NA 95% Rat Human +DTXSID30349419 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30349419 Fup 0.0929 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30349419 Vd NA 0.311 L/kg 1compartment NA NA Human Human +DTXSID30349419 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30349419 TK.Half.Life NA 2.141 hours 1compartment NA NA Human Human +DTXSID30349419 Css NA 0.6954 mg/L 3compartmentss NA 50% Human Human +DTXSID30349419 Css NA 4.783 mg/L 3compartmentss NA 95% Human Human +DTXSID30349419 Css NA 0.4316 mg/L PBTK NA 50% Human Human +DTXSID30349419 Css NA 2.904 mg/L PBTK NA 95% Human Human +DTXSID30349419 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30349419 Fup 0.0929 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30349419 Vd NA 0.3058 L/kg 1compartment NA NA Rat Human +DTXSID30349419 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30349419 TK.Half.Life NA 1.289 hours 1compartment NA NA Rat Human +DTXSID30349419 Css NA 0.009951 mg/L 3compartmentss NA 50% Rat Human +DTXSID30349419 Css NA 0.08032 mg/L 3compartmentss NA 95% Rat Human +DTXSID30349419 Css NA 0.005871 mg/L PBTK NA 50% Rat Human +DTXSID30349419 Css NA 0.04562 mg/L PBTK NA 95% Rat Human +DTXSID3034957 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034957 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3034957 Vd NA 2.516 L/kg 1compartment NA NA Human Human +DTXSID3034957 Days.Css NA 32 Days PBTK NA NA Human Human +DTXSID3034957 TK.Half.Life NA 160.2 hours 1compartment NA NA Human Human +DTXSID3034957 Css NA 6.722 mg/L 3compartmentss NA 50% Human Human +DTXSID3034957 Css NA 20.46 mg/L 3compartmentss NA 95% Human Human +DTXSID3034957 Css NA 5.047 mg/L PBTK NA 50% Human Human +DTXSID3034957 Css NA 13.9 mg/L PBTK NA 95% Human Human +DTXSID3034957 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034957 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3034957 Vd NA 1.932 L/kg 1compartment NA NA Rat Human +DTXSID3034957 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID3034957 TK.Half.Life NA 21.29 hours 1compartment NA NA Rat Human +DTXSID3034957 Css NA 0.4232 mg/L 3compartmentss NA 50% Rat Human +DTXSID3034957 Css NA 1.067 mg/L 3compartmentss NA 95% Rat Human +DTXSID3034957 Css NA 0.3166 mg/L PBTK NA 50% Rat Human +DTXSID3034957 Css NA 0.6886 mg/L PBTK NA 95% Rat Human +DTXSID3035341 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3035341 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3035341 Vd NA 0.9978 L/kg 1compartment NA NA Human Human +DTXSID3035341 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3035341 TK.Half.Life NA 17.17 hours 1compartment NA NA Human Human +DTXSID3035341 Css NA 1.772 mg/L 3compartmentss NA 50% Human Human +DTXSID3035341 Css NA 7.483 mg/L 3compartmentss NA 95% Human Human +DTXSID3035341 Css NA 1.385 mg/L PBTK NA 50% Human Human +DTXSID3035341 Css NA 4.943 mg/L PBTK NA 95% Human Human +DTXSID3035341 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3035341 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3035341 Vd NA 0.8862 L/kg 1compartment NA NA Rat Human +DTXSID3035341 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3035341 TK.Half.Life NA 4.94 hours 1compartment NA NA Rat Human +DTXSID3035341 Css NA 0.1109 mg/L 3compartmentss NA 50% Rat Human +DTXSID3035341 Css NA 0.4116 mg/L 3compartmentss NA 95% Rat Human +DTXSID3035341 Css NA 0.08644 mg/L PBTK NA 50% Rat Human +DTXSID3035341 Css NA 0.26 mg/L PBTK NA 95% Rat Human DTXSID3036496 Clint 9.89 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3036496 Fup 0.0369 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3036496 Vd NA 1.326 L/kg 1compartment NA NA Human Human +DTXSID3036496 Vd NA 1.261 L/kg 1compartment NA NA Human Human DTXSID3036496 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3036496 TK.Half.Life NA 14.83 hours 1compartment NA NA Human Human -DTXSID3036496 Css NA 1.44 mg/L 3compartmentss NA 50% Human Human -DTXSID3036496 Css NA 9.807 mg/L 3compartmentss NA 95% Human Human -DTXSID3036496 Css NA 0.9173 mg/L PBTK NA 50% Human Human -DTXSID3036496 Css NA 5.975 mg/L PBTK NA 95% Human Human +DTXSID3036496 TK.Half.Life NA 13.95 hours 1compartment NA NA Human Human +DTXSID3036496 Css NA 1.391 mg/L 3compartmentss NA 50% Human Human +DTXSID3036496 Css NA 9.632 mg/L 3compartmentss NA 95% Human Human +DTXSID3036496 Css NA 0.8864 mg/L PBTK NA 50% Human Human +DTXSID3036496 Css NA 5.905 mg/L PBTK NA 95% Human Human DTXSID3036496 Clint 31.6 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID3036496 Fup 0.0194 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID3036496 Vd NA 0.7244 L/kg 1compartment NA NA Rat Rat +DTXSID3036496 Vd NA 0.6874 L/kg 1compartment NA NA Rat Rat DTXSID3036496 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID3036496 TK.Half.Life NA 2.812 hours 1compartment NA NA Rat Rat -DTXSID3036496 Css NA 0.5888 mg/L 3compartmentss NA 50% Rat Rat -DTXSID3036496 Css NA 4.541 mg/L 3compartmentss NA 95% Rat Rat -DTXSID3036496 Css NA 0.3347 mg/L PBTK NA 50% Rat Rat -DTXSID3036496 Css NA 2.492 mg/L PBTK NA 95% Rat Rat -DTXSID3036525 Clint NA 7.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3036525 Fup NA 0.078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3036525 Vd NA 2.613 L/kg 1compartment NA NA Human Human -DTXSID3036525 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3036525 TK.Half.Life NA 37.53 hours 1compartment NA NA Human Human -DTXSID3036525 Css NA 1.892 mg/L 3compartmentss NA 50% Human Human -DTXSID3036525 Css NA 11 mg/L 3compartmentss NA 95% Human Human -DTXSID3036525 Css NA 1.296 mg/L PBTK NA 50% Human Human -DTXSID3036525 Css NA 7.31 mg/L PBTK NA 95% Human Human -DTXSID3036525 Clint NA 7.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3036525 Fup NA 0.078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3036525 Vd NA 1.963 L/kg 1compartment NA NA Rat Human -DTXSID3036525 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3036525 TK.Half.Life NA 8.473 hours 1compartment NA NA Rat Human -DTXSID3036525 Css NA 1.023 mg/L 3compartmentss NA 50% Rat Human -DTXSID3036525 Css NA 4.337 mg/L 3compartmentss NA 95% Rat Human -DTXSID3036525 Css NA 0.6678 mg/L PBTK NA 50% Rat Human -DTXSID3036525 Css NA 2.768 mg/L PBTK NA 95% Rat Human -DTXSID3036999 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3036999 Fup NA 0.6336 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3036999 Vd NA 0.4862 L/kg 1compartment NA NA Human Human +DTXSID3036496 TK.Half.Life NA 2.692 hours 1compartment NA NA Rat Rat +DTXSID3036496 Css NA 0.1332 mg/L 3compartmentss NA 50% Rat Rat +DTXSID3036496 Css NA 1.06 mg/L 3compartmentss NA 95% Rat Rat +DTXSID3036496 Css NA 0.0781 mg/L PBTK NA 50% Rat Rat +DTXSID3036496 Css NA 0.6074 mg/L PBTK NA 95% Rat Rat +DTXSID3036525 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3036525 Fup 0.0446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3036525 Vd NA 2.323 L/kg 1compartment NA NA Human Human +DTXSID3036525 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3036525 TK.Half.Life NA 15.88 hours 1compartment NA NA Human Human +DTXSID3036525 Css NA 0.889 mg/L 3compartmentss NA 50% Human Human +DTXSID3036525 Css NA 6.238 mg/L 3compartmentss NA 95% Human Human +DTXSID3036525 Css NA 0.5913 mg/L PBTK NA 50% Human Human +DTXSID3036525 Css NA 4.009 mg/L PBTK NA 95% Human Human +DTXSID3036525 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3036525 Fup 0.0446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3036525 Vd NA 1.738 L/kg 1compartment NA NA Rat Human +DTXSID3036525 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3036525 TK.Half.Life NA 4.443 hours 1compartment NA NA Rat Human +DTXSID3036525 Css NA 0.1145 mg/L 3compartmentss NA 50% Rat Human +DTXSID3036525 Css NA 0.6289 mg/L 3compartmentss NA 95% Rat Human +DTXSID3036525 Css NA 0.07475 mg/L PBTK NA 50% Rat Human +DTXSID3036525 Css NA 0.3959 mg/L PBTK NA 95% Rat Human +DTXSID3036654 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3036654 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3036654 Vd NA 0.6506 L/kg 1compartment NA NA Human Human +DTXSID3036654 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3036654 TK.Half.Life NA 2.106 hours 1compartment NA NA Human Human +DTXSID3036654 Css NA 0.3146 mg/L 3compartmentss NA 50% Human Human +DTXSID3036654 Css NA 1.813 mg/L 3compartmentss NA 95% Human Human +DTXSID3036654 Css NA 0.2162 mg/L PBTK NA 50% Human Human +DTXSID3036654 Css NA 1.17 mg/L PBTK NA 95% Human Human +DTXSID3036654 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3036654 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3036654 Vd NA 0.5867 L/kg 1compartment NA NA Rat Human +DTXSID3036654 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3036654 TK.Half.Life NA 1.093 hours 1compartment NA NA Rat Human +DTXSID3036654 Css NA 0.03712 mg/L 3compartmentss NA 50% Rat Human +DTXSID3036654 Css NA 0.1632 mg/L 3compartmentss NA 95% Rat Human +DTXSID3036654 Css NA 0.02538 mg/L PBTK NA 50% Rat Human +DTXSID3036654 Css NA 0.1027 mg/L PBTK NA 95% Rat Human +DTXSID30367996 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30367996 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30367996 Vd NA 1.055 L/kg 1compartment NA NA Human Human +DTXSID30367996 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30367996 TK.Half.Life NA 1.449 hours 1compartment NA NA Human Human +DTXSID30367996 Css NA 0.07562 mg/L 3compartmentss NA 50% Human Human +DTXSID30367996 Css NA 0.5632 mg/L 3compartmentss NA 95% Human Human +DTXSID30367996 Css NA 0.0554 mg/L PBTK NA 50% Human Human +DTXSID30367996 Css NA 0.3839 mg/L PBTK NA 95% Human Human +DTXSID30367996 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30367996 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30367996 Vd NA 0.891 L/kg 1compartment NA NA Rat Human +DTXSID30367996 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30367996 TK.Half.Life NA 0.6342 hours 1compartment NA NA Rat Human +DTXSID30367996 Css NA 0.009472 mg/L 3compartmentss NA 50% Rat Human +DTXSID30367996 Css NA 0.05363 mg/L 3compartmentss NA 95% Rat Human +DTXSID30367996 Css NA 0.006926 mg/L PBTK NA 50% Rat Human +DTXSID30367996 Css NA 0.03591 mg/L PBTK NA 95% Rat Human +DTXSID3036999 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3036999 Fup 0.439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3036999 Vd NA 0.3991 L/kg 1compartment NA NA Human Human DTXSID3036999 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3036999 TK.Half.Life NA 4.965 hours 1compartment NA NA Human Human -DTXSID3036999 Css NA 1.265 mg/L 3compartmentss NA 50% Human Human -DTXSID3036999 Css NA 8.049 mg/L 3compartmentss NA 95% Human Human -DTXSID3036999 Css NA 0.951 mg/L PBTK NA 50% Human Human -DTXSID3036999 Css NA 4.984 mg/L PBTK NA 95% Human Human -DTXSID3036999 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3036999 Fup NA 0.6336 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3036999 Vd NA 0.5075 L/kg 1compartment NA NA Rat Human +DTXSID3036999 TK.Half.Life NA 5.884 hours 1compartment NA NA Human Human +DTXSID3036999 Css NA 0.9205 mg/L 3compartmentss NA 50% Human Human +DTXSID3036999 Css NA 4.354 mg/L 3compartmentss NA 95% Human Human +DTXSID3036999 Css NA 0.6586 mg/L PBTK NA 50% Human Human +DTXSID3036999 Css NA 2.756 mg/L PBTK NA 95% Human Human +DTXSID3036999 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3036999 Fup 0.439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3036999 Vd NA 0.4216 L/kg 1compartment NA NA Rat Human DTXSID3036999 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3036999 TK.Half.Life NA 1.766 hours 1compartment NA NA Rat Human -DTXSID3036999 Css NA 0.3282 mg/L 3compartmentss NA 50% Rat Human -DTXSID3036999 Css NA 1.994 mg/L 3compartmentss NA 95% Rat Human -DTXSID3036999 Css NA 0.2369 mg/L PBTK NA 50% Rat Human -DTXSID3036999 Css NA 1.151 mg/L PBTK NA 95% Rat Human +DTXSID3036999 TK.Half.Life NA 2.118 hours 1compartment NA NA Rat Human +DTXSID3036999 Css NA 0.005002 mg/L 3compartmentss NA 50% Rat Human +DTXSID3036999 Css NA 0.0242 mg/L 3compartmentss NA 95% Rat Human +DTXSID3036999 Css NA 0.003394 mg/L PBTK NA 50% Rat Human +DTXSID3036999 Css NA 0.01451 mg/L PBTK NA 95% Rat Human DTXSID3037044 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3037044 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3037044 Vd NA 1.313 L/kg 1compartment NA NA Human Human +DTXSID3037044 Vd NA 1.307 L/kg 1compartment NA NA Human Human DTXSID3037044 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3037044 TK.Half.Life NA 2.181 hours 1compartment NA NA Human Human -DTXSID3037044 Css NA 0.07585 mg/L 3compartmentss NA 50% Human Human -DTXSID3037044 Css NA 0.61 mg/L 3compartmentss NA 95% Human Human -DTXSID3037044 Css NA 0.07066 mg/L PBTK NA 50% Human Human -DTXSID3037044 Css NA 0.4291 mg/L PBTK NA 95% Human Human +DTXSID3037044 TK.Half.Life NA 2.17 hours 1compartment NA NA Human Human +DTXSID3037044 Css NA 0.06748 mg/L 3compartmentss NA 50% Human Human +DTXSID3037044 Css NA 0.4503 mg/L 3compartmentss NA 95% Human Human +DTXSID3037044 Css NA 0.06978 mg/L PBTK NA 50% Human Human +DTXSID3037044 Css NA 0.4676 mg/L PBTK NA 95% Human Human DTXSID3037044 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3037044 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3037044 Vd NA 1.274 L/kg 1compartment NA NA Rat Human +DTXSID3037044 Vd NA 1.27 L/kg 1compartment NA NA Rat Human DTXSID3037044 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3037044 TK.Half.Life NA 1.111 hours 1compartment NA NA Rat Human -DTXSID3037044 Css NA 0.06514 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037044 Css NA 0.4539 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037044 Css NA 0.06055 mg/L PBTK NA 50% Rat Human -DTXSID3037044 Css NA 0.2958 mg/L PBTK NA 95% Rat Human +DTXSID3037044 TK.Half.Life NA 1.107 hours 1compartment NA NA Rat Human +DTXSID3037044 Css NA 0.0005499 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037044 Css NA 0.003481 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037044 Css NA 0.0005734 mg/L PBTK NA 50% Rat Human +DTXSID3037044 Css NA 0.003635 mg/L PBTK NA 95% Rat Human DTXSID3037094 Clint 16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3037094 Fup 0.0153 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3037094 Vd NA 2.707 L/kg 1compartment NA NA Human Human +DTXSID3037094 Vd NA 2.885 L/kg 1compartment NA NA Human Human DTXSID3037094 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3037094 TK.Half.Life NA 9.686 hours 1compartment NA NA Human Human -DTXSID3037094 Css NA 0.4605 mg/L 3compartmentss NA 50% Human Human -DTXSID3037094 Css NA 3.584 mg/L 3compartmentss NA 95% Human Human -DTXSID3037094 Css NA 0.3202 mg/L PBTK NA 50% Human Human -DTXSID3037094 Css NA 2.324 mg/L PBTK NA 95% Human Human +DTXSID3037094 TK.Half.Life NA 9.774 hours 1compartment NA NA Human Human +DTXSID3037094 Css NA 0.3905 mg/L 3compartmentss NA 50% Human Human +DTXSID3037094 Css NA 3.071 mg/L 3compartmentss NA 95% Human Human +DTXSID3037094 Css NA 0.2716 mg/L PBTK NA 50% Human Human +DTXSID3037094 Css NA 2.041 mg/L PBTK NA 95% Human Human DTXSID3037094 Clint 16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3037094 Fup 0.0153 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3037094 Vd NA 2.15 L/kg 1compartment NA NA Rat Human +DTXSID3037094 Vd NA 2.26 L/kg 1compartment NA NA Rat Human DTXSID3037094 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3037094 TK.Half.Life NA 2.94 hours 1compartment NA NA Rat Human -DTXSID3037094 Css NA 0.2544 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037094 Css NA 1.838 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037094 Css NA 0.1668 mg/L PBTK NA 50% Rat Human -DTXSID3037094 Css NA 1.142 mg/L PBTK NA 95% Rat Human +DTXSID3037094 TK.Half.Life NA 2.591 hours 1compartment NA NA Rat Human +DTXSID3037094 Css NA 0.05057 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037094 Css NA 0.3436 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037094 Css NA 0.03488 mg/L PBTK NA 50% Rat Human +DTXSID3037094 Css NA 0.2256 mg/L PBTK NA 95% Rat Human +DTXSID3037125 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID3037125 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3037125 Vd NA 1.292 L/kg 1compartment NA NA Human Human +DTXSID3037125 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3037125 TK.Half.Life NA 24.52 hours 1compartment NA NA Human Human +DTXSID3037125 Css NA 2.637 mg/L 3compartmentss NA 50% Human Human +DTXSID3037125 Css NA 17.08 mg/L 3compartmentss NA 95% Human Human +DTXSID3037125 Css NA 1.686 mg/L PBTK NA 50% Human Human +DTXSID3037125 Css NA 10.93 mg/L PBTK NA 95% Human Human +DTXSID3037125 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID3037125 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3037125 Vd NA 1.231 L/kg 1compartment NA NA Rat Human +DTXSID3037125 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3037125 TK.Half.Life NA 13.73 hours 1compartment NA NA Rat Human +DTXSID3037125 Css NA 0.1074 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037125 Css NA 0.8239 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037125 Css NA 0.06984 mg/L PBTK NA 50% Rat Human +DTXSID3037125 Css NA 0.5442 mg/L PBTK NA 95% Rat Human DTXSID3037208 Clint 38.84 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID3037208 Fup 0.004131 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID3037208 Vd NA 0.2157 L/kg 1compartment NA NA Human Human +DTXSID3037208 Vd NA 0.1641 L/kg 1compartment NA NA Human Human DTXSID3037208 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3037208 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human -DTXSID3037208 Css NA 3.503 mg/L 3compartmentss NA 50% Human Human -DTXSID3037208 Css NA 30.97 mg/L 3compartmentss NA 95% Human Human -DTXSID3037208 Css NA 2.057 mg/L PBTK NA 50% Human Human -DTXSID3037208 Css NA 18.22 mg/L PBTK NA 95% Human Human +DTXSID3037208 TK.Half.Life NA 4.002 hours 1compartment NA NA Human Human +DTXSID3037208 Css NA 3.458 mg/L 3compartmentss NA 50% Human Human +DTXSID3037208 Css NA 32.28 mg/L 3compartmentss NA 95% Human Human +DTXSID3037208 Css NA 2.01 mg/L PBTK NA 50% Human Human +DTXSID3037208 Css NA 18.87 mg/L PBTK NA 95% Human Human DTXSID3037208 Clint 38.84 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID3037208 Fup 0.004131 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID3037208 Vd NA 0.2012 L/kg 1compartment NA NA Rat Human +DTXSID3037208 Vd NA 0.1625 L/kg 1compartment NA NA Rat Human DTXSID3037208 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3037208 TK.Half.Life NA 3.263 hours 1compartment NA NA Rat Human -DTXSID3037208 Css NA 1.982 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037208 Css NA 13.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037208 Css NA 1.088 mg/L PBTK NA 50% Rat Human -DTXSID3037208 Css NA 7.565 mg/L PBTK NA 95% Rat Human -DTXSID3037250 Clint NA 4.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3037250 Fup NA 0.0182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3037250 Vd NA 0.5603 L/kg 1compartment NA NA Human Human -DTXSID3037250 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3037250 TK.Half.Life NA 22.66 hours 1compartment NA NA Human Human -DTXSID3037250 Css NA 7.372 mg/L 3compartmentss NA 50% Human Human -DTXSID3037250 Css NA 59.33 mg/L 3compartmentss NA 95% Human Human -DTXSID3037250 Css NA 4.387 mg/L PBTK NA 50% Human Human -DTXSID3037250 Css NA 34.31 mg/L PBTK NA 95% Human Human -DTXSID3037250 Clint NA 4.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3037250 Fup NA 0.0182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3037250 Vd NA 0.4314 L/kg 1compartment NA NA Rat Human -DTXSID3037250 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3037250 TK.Half.Life NA 10.53 hours 1compartment NA NA Rat Human -DTXSID3037250 Css NA 3.774 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037250 Css NA 25.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037250 Css NA 2.106 mg/L PBTK NA 50% Rat Human -DTXSID3037250 Css NA 13.71 mg/L PBTK NA 95% Rat Human +DTXSID3037208 TK.Half.Life NA 2.698 hours 1compartment NA NA Rat Human +DTXSID3037208 Css NA 0.4684 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037208 Css NA 3.349 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037208 Css NA 0.2628 mg/L PBTK NA 50% Rat Human +DTXSID3037208 Css NA 1.874 mg/L PBTK NA 95% Rat Human +DTXSID3037250 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3037250 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3037250 Vd NA 0.7374 L/kg 1compartment NA NA Human Human +DTXSID3037250 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3037250 TK.Half.Life NA 13.25 hours 1compartment NA NA Human Human +DTXSID3037250 Css NA 3.048 mg/L 3compartmentss NA 50% Human Human +DTXSID3037250 Css NA 25.51 mg/L 3compartmentss NA 95% Human Human +DTXSID3037250 Css NA 1.863 mg/L PBTK NA 50% Human Human +DTXSID3037250 Css NA 15.08 mg/L PBTK NA 95% Human Human +DTXSID3037250 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3037250 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3037250 Vd NA 0.5649 L/kg 1compartment NA NA Rat Human +DTXSID3037250 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3037250 TK.Half.Life NA 6.075 hours 1compartment NA NA Rat Human +DTXSID3037250 Css NA 0.3806 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037250 Css NA 2.358 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037250 Css NA 0.2242 mg/L PBTK NA 50% Rat Human +DTXSID3037250 Css NA 1.341 mg/L PBTK NA 95% Rat Human DTXSID3037541 Clint NA 1.409 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3037541 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3037541 Vd NA 1.837 L/kg 1compartment NA NA Human Human -DTXSID3037541 Days.Css NA 40 Days PBTK NA NA Human Human +DTXSID3037541 Days.Css NA 39 Days PBTK NA NA Human Human DTXSID3037541 TK.Half.Life NA 190.4 hours 1compartment NA NA Human Human -DTXSID3037541 Css NA 16.72 mg/L 3compartmentss NA 50% Human Human -DTXSID3037541 Css NA 95.94 mg/L 3compartmentss NA 95% Human Human -DTXSID3037541 Css NA 10.7 mg/L PBTK NA 50% Human Human -DTXSID3037541 Css NA 57.76 mg/L PBTK NA 95% Human Human +DTXSID3037541 Css NA 16.53 mg/L 3compartmentss NA 50% Human Human +DTXSID3037541 Css NA 94.65 mg/L 3compartmentss NA 95% Human Human +DTXSID3037541 Css NA 10.52 mg/L PBTK NA 50% Human Human +DTXSID3037541 Css NA 57.12 mg/L PBTK NA 95% Human Human DTXSID3037541 Clint NA 1.409 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3037541 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3037541 Vd NA 1.365 L/kg 1compartment NA NA Rat Human DTXSID3037541 Days.Css NA 16 Days PBTK NA NA Rat Human DTXSID3037541 TK.Half.Life NA 55.19 hours 1compartment NA NA Rat Human -DTXSID3037541 Css NA 7.715 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037541 Css NA 35.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037541 Css NA 4.646 mg/L PBTK NA 50% Rat Human -DTXSID3037541 Css NA 20.06 mg/L PBTK NA 95% Rat Human -DTXSID3037545 Clint NA 76.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3037545 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3037545 Vd NA 0.305 L/kg 1compartment NA NA Human Human +DTXSID3037541 Css NA 1.747 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037541 Css NA 7.974 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037541 Css NA 1.089 mg/L PBTK NA 50% Rat Human +DTXSID3037541 Css NA 4.618 mg/L PBTK NA 95% Rat Human +DTXSID3037545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3037545 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3037545 Vd NA 0.4149 L/kg 1compartment NA NA Human Human DTXSID3037545 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3037545 TK.Half.Life NA 0.4101 hours 1compartment NA NA Human Human -DTXSID3037545 Css NA 0.07685 mg/L 3compartmentss NA 50% Human Human -DTXSID3037545 Css NA 0.688 mg/L 3compartmentss NA 95% Human Human -DTXSID3037545 Css NA 0.0477 mg/L PBTK NA 50% Human Human -DTXSID3037545 Css NA 0.4079 mg/L PBTK NA 95% Human Human -DTXSID3037545 Clint NA 76.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3037545 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3037545 Vd NA 0.2927 L/kg 1compartment NA NA Rat Human +DTXSID3037545 TK.Half.Life NA 0.6496 hours 1compartment NA NA Human Human +DTXSID3037545 Css NA 0.0976 mg/L 3compartmentss NA 50% Human Human +DTXSID3037545 Css NA 0.6664 mg/L 3compartmentss NA 95% Human Human +DTXSID3037545 Css NA 0.06569 mg/L PBTK NA 50% Human Human +DTXSID3037545 Css NA 0.4262 mg/L PBTK NA 95% Human Human +DTXSID3037545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3037545 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3037545 Vd NA 0.3988 L/kg 1compartment NA NA Rat Human DTXSID3037545 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3037545 TK.Half.Life NA 0.2046 hours 1compartment NA NA Rat Human -DTXSID3037545 Css NA 0.04452 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037545 Css NA 0.2923 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037545 Css NA 0.02583 mg/L PBTK NA 50% Rat Human -DTXSID3037545 Css NA 0.1648 mg/L PBTK NA 95% Rat Human -DTXSID3037626 Clint NA 0.6238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3037626 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3037626 Vd NA 2.811 L/kg 1compartment NA NA Human Human -DTXSID3037626 Days.Css NA 221 Days PBTK NA NA Human Human -DTXSID3037626 TK.Half.Life NA 884.5 hours 1compartment NA NA Human Human -DTXSID3037626 Css NA 42.22 mg/L 3compartmentss NA 50% Human Human -DTXSID3037626 Css NA 165.3 mg/L 3compartmentss NA 95% Human Human -DTXSID3037626 Css NA 28.74 mg/L PBTK NA 50% Human Human -DTXSID3037626 Css NA 105.5 mg/L PBTK NA 95% Human Human -DTXSID3037626 Clint NA 0.6238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3037626 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3037626 Vd NA 2.104 L/kg 1compartment NA NA Rat Human -DTXSID3037626 Days.Css NA 93 Days PBTK NA NA Rat Human -DTXSID3037626 TK.Half.Life NA 133.3 hours 1compartment NA NA Rat Human -DTXSID3037626 Css NA 18.91 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037626 Css NA 53.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037626 Css NA 12.26 mg/L PBTK NA 50% Rat Human -DTXSID3037626 Css NA 31.88 mg/L PBTK NA 95% Rat Human +DTXSID3037545 TK.Half.Life NA 0.3411 hours 1compartment NA NA Rat Human +DTXSID3037545 Css NA 0.0124 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037545 Css NA 0.06887 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037545 Css NA 0.008187 mg/L PBTK NA 50% Rat Human +DTXSID3037545 Css NA 0.04347 mg/L PBTK NA 95% Rat Human +DTXSID3037626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3037626 Fup 0.00526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3037626 Vd NA 2.439 L/kg 1compartment NA NA Human Human +DTXSID3037626 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID3037626 TK.Half.Life NA 55.81 hours 1compartment NA NA Human Human +DTXSID3037626 Css NA 3.338 mg/L 3compartmentss NA 50% Human Human +DTXSID3037626 Css NA 26.32 mg/L 3compartmentss NA 95% Human Human +DTXSID3037626 Css NA 2.195 mg/L PBTK NA 50% Human Human +DTXSID3037626 Css NA 16.72 mg/L PBTK NA 95% Human Human +DTXSID3037626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3037626 Fup 0.00526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3037626 Vd NA 1.812 L/kg 1compartment NA NA Rat Human +DTXSID3037626 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID3037626 TK.Half.Life NA 14.13 hours 1compartment NA NA Rat Human +DTXSID3037626 Css NA 0.4333 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037626 Css NA 2.823 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037626 Css NA 0.2777 mg/L PBTK NA 50% Rat Human +DTXSID3037626 Css NA 1.76 mg/L PBTK NA 95% Rat Human DTXSID3037672 Clint NA 0.001199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3037672 Fup NA 0.4361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3037672 Vd NA 0.4203 L/kg 1compartment NA NA Human Human +DTXSID3037672 Vd NA 0.3116 L/kg 1compartment NA NA Human Human DTXSID3037672 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3037672 TK.Half.Life NA 6.222 hours 1compartment NA NA Human Human -DTXSID3037672 Css NA 1.749 mg/L 3compartmentss NA 50% Human Human -DTXSID3037672 Css NA 8.007 mg/L 3compartmentss NA 95% Human Human -DTXSID3037672 Css NA 1.247 mg/L PBTK NA 50% Human Human -DTXSID3037672 Css NA 5.007 mg/L PBTK NA 95% Human Human +DTXSID3037672 TK.Half.Life NA 4.581 hours 1compartment NA NA Human Human +DTXSID3037672 Css NA 1.552 mg/L 3compartmentss NA 50% Human Human +DTXSID3037672 Css NA 6.914 mg/L 3compartmentss NA 95% Human Human +DTXSID3037672 Css NA 1.049 mg/L PBTK NA 50% Human Human +DTXSID3037672 Css NA 4.164 mg/L PBTK NA 95% Human Human DTXSID3037672 Clint NA 0.001199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3037672 Fup NA 0.4361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3037672 Vd NA 0.4262 L/kg 1compartment NA NA Rat Human +DTXSID3037672 Vd NA 0.3311 L/kg 1compartment NA NA Rat Human DTXSID3037672 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3037672 TK.Half.Life NA 2.153 hours 1compartment NA NA Rat Human -DTXSID3037672 Css NA 0.473 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037672 Css NA 1.863 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037672 Css NA 0.3214 mg/L PBTK NA 50% Rat Human -DTXSID3037672 Css NA 1.083 mg/L PBTK NA 95% Rat Human -DTXSID3037707 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3037707 Fup 0.01933 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3037707 Vd NA 0.2492 L/kg 1compartment NA NA Human Human -DTXSID3037707 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID3037707 TK.Half.Life NA 83.4 hours 1compartment NA NA Human Human -DTXSID3037707 Css NA 56.45 mg/L 3compartmentss NA 50% Human Human -DTXSID3037707 Css NA 352.7 mg/L 3compartmentss NA 95% Human Human -DTXSID3037707 Css NA 33.61 mg/L PBTK NA 50% Human Human -DTXSID3037707 Css NA 204.8 mg/L PBTK NA 95% Human Human -DTXSID3037707 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3037707 Fup 0.01933 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3037707 Vd NA 0.2424 L/kg 1compartment NA NA Rat Human -DTXSID3037707 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID3037707 TK.Half.Life NA 27.65 hours 1compartment NA NA Rat Human -DTXSID3037707 Css NA 16.25 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037707 Css NA 85.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037707 Css NA 9.041 mg/L PBTK NA 50% Rat Human -DTXSID3037707 Css NA 46.66 mg/L PBTK NA 95% Rat Human -DTXSID3037709 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3037709 Fup 0.001342 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3037709 Vd NA 0.1637 L/kg 1compartment NA NA Human Human -DTXSID3037709 Days.Css NA 237 Days PBTK NA NA Human Human -DTXSID3037709 TK.Half.Life NA 789.1 hours 1compartment NA NA Human Human -DTXSID3037709 Css NA 850.7 mg/L 3compartmentss NA 50% Human Human -DTXSID3037709 Css NA 4054 mg/L 3compartmentss NA 95% Human Human -DTXSID3037709 Css NA 495.8 mg/L PBTK NA 50% Human Human -DTXSID3037709 Css NA 2350 mg/L PBTK NA 95% Human Human -DTXSID3037709 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3037709 Fup 0.001342 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3037709 Vd NA 0.1619 L/kg 1compartment NA NA Rat Human -DTXSID3037709 Days.Css NA 73 Days PBTK NA NA Rat Human -DTXSID3037709 TK.Half.Life NA 266 hours 1compartment NA NA Rat Human -DTXSID3037709 Css NA 243.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID3037709 Css NA 991.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID3037709 Css NA 131.8 mg/L PBTK NA 50% Rat Human -DTXSID3037709 Css NA 535.5 mg/L PBTK NA 95% Rat Human -DTXSID3038694 Clint NA 0.7046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3038694 Fup NA 0.8065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3038694 Vd NA 1.11 L/kg 1compartment NA NA Human Human +DTXSID3037672 TK.Half.Life NA 1.667 hours 1compartment NA NA Rat Human +DTXSID3037672 Css NA 0.02864 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037672 Css NA 0.1784 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037672 Css NA 0.01845 mg/L PBTK NA 50% Rat Human +DTXSID3037672 Css NA 0.1065 mg/L PBTK NA 95% Rat Human +DTXSID3037703 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3037703 Fup 0.0956 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3037703 Vd NA 0.3754 L/kg 1compartment NA NA Human Human +DTXSID3037703 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3037703 TK.Half.Life NA 2.511 hours 1compartment NA NA Human Human +DTXSID3037703 Css NA 0.9438 mg/L 3compartmentss NA 50% Human Human +DTXSID3037703 Css NA 6.79 mg/L 3compartmentss NA 95% Human Human +DTXSID3037703 Css NA 0.6044 mg/L PBTK NA 50% Human Human +DTXSID3037703 Css NA 4.081 mg/L PBTK NA 95% Human Human +DTXSID3037703 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3037703 Fup 0.0956 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3037703 Vd NA 0.3711 L/kg 1compartment NA NA Rat Human +DTXSID3037703 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3037703 TK.Half.Life NA 1.519 hours 1compartment NA NA Rat Human +DTXSID3037703 Css NA 0.1168 mg/L 3compartmentss NA 50% Rat Human +DTXSID3037703 Css NA 0.6007 mg/L 3compartmentss NA 95% Rat Human +DTXSID3037703 Css NA 0.07188 mg/L PBTK NA 50% Rat Human +DTXSID3037703 Css NA 0.3478 mg/L PBTK NA 95% Rat Human +DTXSID30386304 Clint 0.8591 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30386304 Fup 0.0431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30386304 Vd NA 3.324 L/kg 1compartment NA NA Human Human +DTXSID30386304 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID30386304 TK.Half.Life NA 77.94 hours 1compartment NA NA Human Human +DTXSID30386304 Css NA 2.741 mg/L 3compartmentss NA 50% Human Human +DTXSID30386304 Css NA 16.47 mg/L 3compartmentss NA 95% Human Human +DTXSID30386304 Css NA 2.145 mg/L PBTK NA 50% Human Human +DTXSID30386304 Css NA 11.99 mg/L PBTK NA 95% Human Human +DTXSID30386304 Clint 0.8591 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30386304 Fup 0.0431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30386304 Vd NA 2.743 L/kg 1compartment NA NA Rat Human +DTXSID30386304 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID30386304 TK.Half.Life NA 19.15 hours 1compartment NA NA Rat Human +DTXSID30386304 Css NA 0.3368 mg/L 3compartmentss NA 50% Rat Human +DTXSID30386304 Css NA 1.565 mg/L 3compartmentss NA 95% Rat Human +DTXSID30386304 Css NA 0.2637 mg/L PBTK NA 50% Rat Human +DTXSID30386304 Css NA 1.168 mg/L PBTK NA 95% Rat Human +DTXSID3038694 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3038694 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3038694 Vd NA 0.6074 L/kg 1compartment NA NA Human Human DTXSID3038694 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3038694 TK.Half.Life NA 4.429 hours 1compartment NA NA Human Human -DTXSID3038694 Css NA 0.4294 mg/L 3compartmentss NA 50% Human Human -DTXSID3038694 Css NA 2.875 mg/L 3compartmentss NA 95% Human Human -DTXSID3038694 Css NA 0.3797 mg/L PBTK NA 50% Human Human -DTXSID3038694 Css NA 1.926 mg/L PBTK NA 95% Human Human -DTXSID3038694 Clint NA 0.7046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3038694 Fup NA 0.8065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3038694 Vd NA 1.057 L/kg 1compartment NA NA Rat Human +DTXSID3038694 TK.Half.Life NA 0.8169 hours 1compartment NA NA Human Human +DTXSID3038694 Css NA 0.0716 mg/L 3compartmentss NA 50% Human Human +DTXSID3038694 Css NA 0.5551 mg/L 3compartmentss NA 95% Human Human +DTXSID3038694 Css NA 0.05026 mg/L PBTK NA 50% Human Human +DTXSID3038694 Css NA 0.362 mg/L PBTK NA 95% Human Human +DTXSID3038694 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3038694 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3038694 Vd NA 0.5743 L/kg 1compartment NA NA Rat Human DTXSID3038694 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3038694 TK.Half.Life NA 1.889 hours 1compartment NA NA Rat Human -DTXSID3038694 Css NA 0.1515 mg/L 3compartmentss NA 50% Rat Human -DTXSID3038694 Css NA 1.026 mg/L 3compartmentss NA 95% Rat Human -DTXSID3038694 Css NA 0.1328 mg/L PBTK NA 50% Rat Human -DTXSID3038694 Css NA 0.6283 mg/L PBTK NA 95% Rat Human -DTXSID3038696 Clint NA 34.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3038696 Fup NA 0.2913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3038696 Vd NA 2.164 L/kg 1compartment NA NA Human Human -DTXSID3038696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3038696 TK.Half.Life NA 2.886 hours 1compartment NA NA Human Human -DTXSID3038696 Css NA 0.07385 mg/L 3compartmentss NA 50% Human Human -DTXSID3038696 Css NA 0.4948 mg/L 3compartmentss NA 95% Human Human -DTXSID3038696 Css NA 0.05603 mg/L PBTK NA 50% Human Human -DTXSID3038696 Css NA 0.3529 mg/L PBTK NA 95% Human Human -DTXSID3038696 Clint NA 34.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3038696 Fup NA 0.2913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3038696 Vd NA 1.684 L/kg 1compartment NA NA Rat Human -DTXSID3038696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3038696 TK.Half.Life NA 0.9607 hours 1compartment NA NA Rat Human -DTXSID3038696 Css NA 0.04028 mg/L 3compartmentss NA 50% Rat Human -DTXSID3038696 Css NA 0.2165 mg/L 3compartmentss NA 95% Rat Human -DTXSID3038696 Css NA 0.02932 mg/L PBTK NA 50% Rat Human -DTXSID3038696 Css NA 0.1458 mg/L PBTK NA 95% Rat Human -DTXSID3038800 Clint NA 24.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3038800 Fup NA 0.5788 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3038800 Vd NA 1.533 L/kg 1compartment NA NA Human Human +DTXSID3038694 TK.Half.Life NA 0.4104 hours 1compartment NA NA Rat Human +DTXSID3038694 Css NA 0.009116 mg/L 3compartmentss NA 50% Rat Human +DTXSID3038694 Css NA 0.05017 mg/L 3compartmentss NA 95% Rat Human +DTXSID3038694 Css NA 0.006363 mg/L PBTK NA 50% Rat Human +DTXSID3038694 Css NA 0.03219 mg/L PBTK NA 95% Rat Human +DTXSID3038800 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3038800 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3038800 Vd NA 1.283 L/kg 1compartment NA NA Human Human DTXSID3038800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3038800 TK.Half.Life NA 1.367 hours 1compartment NA NA Human Human -DTXSID3038800 Css NA 0.03506 mg/L 3compartmentss NA 50% Human Human -DTXSID3038800 Css NA 0.335 mg/L 3compartmentss NA 95% Human Human -DTXSID3038800 Css NA 0.02998 mg/L PBTK NA 50% Human Human -DTXSID3038800 Css NA 0.2363 mg/L PBTK NA 95% Human Human -DTXSID3038800 Clint NA 24.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3038800 Fup NA 0.5788 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3038800 Vd NA 1.31 L/kg 1compartment NA NA Rat Human +DTXSID3038800 TK.Half.Life NA 1.163 hours 1compartment NA NA Human Human +DTXSID3038800 Css NA 0.03362 mg/L 3compartmentss NA 50% Human Human +DTXSID3038800 Css NA 0.361 mg/L 3compartmentss NA 95% Human Human +DTXSID3038800 Css NA 0.0285 mg/L PBTK NA 50% Human Human +DTXSID3038800 Css NA 0.2453 mg/L PBTK NA 95% Human Human +DTXSID3038800 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3038800 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3038800 Vd NA 1.135 L/kg 1compartment NA NA Rat Human DTXSID3038800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3038800 TK.Half.Life NA 0.5532 hours 1compartment NA NA Rat Human -DTXSID3038800 Css NA 0.01762 mg/L 3compartmentss NA 50% Rat Human -DTXSID3038800 Css NA 0.156 mg/L 3compartmentss NA 95% Rat Human -DTXSID3038800 Css NA 0.01472 mg/L PBTK NA 50% Rat Human -DTXSID3038800 Css NA 0.1064 mg/L PBTK NA 95% Rat Human -DTXSID3038852 Clint NA 0.9332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3038852 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3038852 Vd NA 0.2241 L/kg 1compartment NA NA Human Human -DTXSID3038852 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3038852 TK.Half.Life NA 11.9 hours 1compartment NA NA Human Human -DTXSID3038852 Css NA 9.014 mg/L 3compartmentss NA 50% Human Human -DTXSID3038852 Css NA 50.66 mg/L 3compartmentss NA 95% Human Human -DTXSID3038852 Css NA 5.409 mg/L PBTK NA 50% Human Human -DTXSID3038852 Css NA 29.43 mg/L PBTK NA 95% Human Human -DTXSID3038852 Clint NA 0.9332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3038852 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3038852 Vd NA 0.2205 L/kg 1compartment NA NA Rat Human +DTXSID3038800 TK.Half.Life NA 0.5016 hours 1compartment NA NA Rat Human +DTXSID3038800 Css NA 0.004112 mg/L 3compartmentss NA 50% Rat Human +DTXSID3038800 Css NA 0.03811 mg/L 3compartmentss NA 95% Rat Human +DTXSID3038800 Css NA 0.003538 mg/L PBTK NA 50% Rat Human +DTXSID3038800 Css NA 0.02628 mg/L PBTK NA 95% Rat Human +DTXSID3038852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3038852 Fup 0.0563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3038852 Vd NA 0.2557 L/kg 1compartment NA NA Human Human +DTXSID3038852 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3038852 TK.Half.Life NA 1.022 hours 1compartment NA NA Human Human +DTXSID3038852 Css NA 0.5478 mg/L 3compartmentss NA 50% Human Human +DTXSID3038852 Css NA 4.34 mg/L 3compartmentss NA 95% Human Human +DTXSID3038852 Css NA 0.3322 mg/L PBTK NA 50% Human Human +DTXSID3038852 Css NA 2.545 mg/L PBTK NA 95% Human Human +DTXSID3038852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3038852 Fup 0.0563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3038852 Vd NA 0.2495 L/kg 1compartment NA NA Rat Human DTXSID3038852 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3038852 TK.Half.Life NA 5.781 hours 1compartment NA NA Rat Human -DTXSID3038852 Css NA 3.747 mg/L 3compartmentss NA 50% Rat Human -DTXSID3038852 Css NA 17.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID3038852 Css NA 2.093 mg/L PBTK NA 50% Rat Human -DTXSID3038852 Css NA 9.337 mg/L PBTK NA 95% Rat Human -DTXSID3038939 Clint 11.93 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3038939 Fup 0.001515 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3038939 Vd NA 1.083 L/kg 1compartment NA NA Human Human -DTXSID3038939 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID3038939 TK.Half.Life NA 99.79 hours 1compartment NA NA Human Human -DTXSID3038939 Css NA 16.91 mg/L 3compartmentss NA 50% Human Human -DTXSID3038939 Css NA 138.7 mg/L 3compartmentss NA 95% Human Human -DTXSID3038939 Css NA 10.16 mg/L PBTK NA 50% Human Human -DTXSID3038939 Css NA 81.82 mg/L PBTK NA 95% Human Human -DTXSID3038939 Clint 11.93 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3038939 Fup 0.001515 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3038939 Vd NA 0.7899 L/kg 1compartment NA NA Rat Human -DTXSID3038939 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID3038939 TK.Half.Life NA 43.08 hours 1compartment NA NA Rat Human -DTXSID3038939 Css NA 9.635 mg/L 3compartmentss NA 50% Rat Human -DTXSID3038939 Css NA 61.53 mg/L 3compartmentss NA 95% Rat Human -DTXSID3038939 Css NA 5.401 mg/L PBTK NA 50% Rat Human -DTXSID3038939 Css NA 34 mg/L PBTK NA 95% Rat Human +DTXSID3038852 TK.Half.Life NA 0.6211 hours 1compartment NA NA Rat Human +DTXSID3038852 Css NA 0.07181 mg/L 3compartmentss NA 50% Rat Human +DTXSID3038852 Css NA 0.4543 mg/L 3compartmentss NA 95% Rat Human +DTXSID3038852 Css NA 0.04223 mg/L PBTK NA 50% Rat Human +DTXSID3038852 Css NA 0.2624 mg/L PBTK NA 95% Rat Human +DTXSID30390643 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30390643 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30390643 Vd NA 0.7638 L/kg 1compartment NA NA Human Human +DTXSID30390643 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30390643 TK.Half.Life NA 3.527 hours 1compartment NA NA Human Human +DTXSID30390643 Css NA 0.4748 mg/L 3compartmentss NA 50% Human Human +DTXSID30390643 Css NA 2.495 mg/L 3compartmentss NA 95% Human Human +DTXSID30390643 Css NA 0.3405 mg/L PBTK NA 50% Human Human +DTXSID30390643 Css NA 1.613 mg/L PBTK NA 95% Human Human +DTXSID30390643 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30390643 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30390643 Vd NA 0.6817 L/kg 1compartment NA NA Rat Human +DTXSID30390643 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30390643 TK.Half.Life NA 1.731 hours 1compartment NA NA Rat Human +DTXSID30390643 Css NA 0.05232 mg/L 3compartmentss NA 50% Rat Human +DTXSID30390643 Css NA 0.2101 mg/L 3compartmentss NA 95% Rat Human +DTXSID30390643 Css NA 0.03714 mg/L PBTK NA 50% Rat Human +DTXSID30390643 Css NA 0.1316 mg/L PBTK NA 95% Rat Human DTXSID3039240 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3039240 Fup NA 0.9174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3039240 Vd NA 0.737 L/kg 1compartment NA NA Human Human +DTXSID3039240 Vd NA 0.6637 L/kg 1compartment NA NA Human Human DTXSID3039240 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3039240 TK.Half.Life NA 5.196 hours 1compartment NA NA Human Human -DTXSID3039240 Css NA 0.8794 mg/L 3compartmentss NA 50% Human Human -DTXSID3039240 Css NA 3.278 mg/L 3compartmentss NA 95% Human Human -DTXSID3039240 Css NA 0.734 mg/L PBTK NA 50% Human Human -DTXSID3039240 Css NA 2.285 mg/L PBTK NA 95% Human Human +DTXSID3039240 TK.Half.Life NA 4.68 hours 1compartment NA NA Human Human +DTXSID3039240 Css NA 0.7638 mg/L 3compartmentss NA 50% Human Human +DTXSID3039240 Css NA 2.848 mg/L 3compartmentss NA 95% Human Human +DTXSID3039240 Css NA 0.6215 mg/L PBTK NA 50% Human Human +DTXSID3039240 Css NA 1.969 mg/L PBTK NA 95% Human Human DTXSID3039240 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3039240 Fup NA 0.9174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3039240 Vd NA 0.7746 L/kg 1compartment NA NA Rat Human +DTXSID3039240 Vd NA 0.711 L/kg 1compartment NA NA Rat Human DTXSID3039240 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3039240 TK.Half.Life NA 1.862 hours 1compartment NA NA Rat Human -DTXSID3039240 Css NA 0.2261 mg/L 3compartmentss NA 50% Rat Human -DTXSID3039240 Css NA 0.7895 mg/L 3compartmentss NA 95% Rat Human -DTXSID3039240 Css NA 0.1839 mg/L PBTK NA 50% Rat Human -DTXSID3039240 Css NA 0.5049 mg/L PBTK NA 95% Rat Human -DTXSID3040279 Clint NA 19.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040279 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040279 Vd NA 5.048 L/kg 1compartment NA NA Human Human -DTXSID3040279 Days.Css NA 31 Days PBTK NA NA Human Human -DTXSID3040279 TK.Half.Life NA 165.8 hours 1compartment NA NA Human Human -DTXSID3040279 Css NA 3.256 mg/L 3compartmentss NA 50% Human Human -DTXSID3040279 Css NA 18.89 mg/L 3compartmentss NA 95% Human Human -DTXSID3040279 Css NA 2.662 mg/L PBTK NA 50% Human Human -DTXSID3040279 Css NA 15.14 mg/L PBTK NA 95% Human Human -DTXSID3040279 Clint NA 19.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040279 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040279 Vd NA 3.856 L/kg 1compartment NA NA Rat Human -DTXSID3040279 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID3040279 TK.Half.Life NA 22.69 hours 1compartment NA NA Rat Human -DTXSID3040279 Css NA 1.822 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040279 Css NA 7.929 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040279 Css NA 1.438 mg/L PBTK NA 50% Rat Human -DTXSID3040279 Css NA 6.238 mg/L PBTK NA 95% Rat Human -DTXSID3040352 Clint NA 12.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040352 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040352 Vd NA 1.74 L/kg 1compartment NA NA Human Human -DTXSID3040352 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3040352 TK.Half.Life NA 9.61 hours 1compartment NA NA Human Human -DTXSID3040352 Css NA 0.741 mg/L 3compartmentss NA 50% Human Human -DTXSID3040352 Css NA 5.105 mg/L 3compartmentss NA 95% Human Human -DTXSID3040352 Css NA 0.4897 mg/L PBTK NA 50% Human Human -DTXSID3040352 Css NA 3.212 mg/L PBTK NA 95% Human Human -DTXSID3040352 Clint NA 12.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040352 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040352 Vd NA 1.315 L/kg 1compartment NA NA Rat Human -DTXSID3040352 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3040352 TK.Half.Life NA 3.448 hours 1compartment NA NA Rat Human -DTXSID3040352 Css NA 0.4062 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040352 Css NA 2.106 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040352 Css NA 0.2532 mg/L PBTK NA 50% Rat Human -DTXSID3040352 Css NA 1.246 mg/L PBTK NA 95% Rat Human -DTXSID3040643 Clint NA 20.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040643 Fup NA 0.3319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040643 Vd NA 2.453 L/kg 1compartment NA NA Human Human +DTXSID3039240 TK.Half.Life NA 1.709 hours 1compartment NA NA Rat Human +DTXSID3039240 Css NA 0.01366 mg/L 3compartmentss NA 50% Rat Human +DTXSID3039240 Css NA 0.07391 mg/L 3compartmentss NA 95% Rat Human +DTXSID3039240 Css NA 0.01066 mg/L PBTK NA 50% Rat Human +DTXSID3039240 Css NA 0.05207 mg/L PBTK NA 95% Rat Human +DTXSID3040279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040279 Fup 0.00595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040279 Vd NA 5.013 L/kg 1compartment NA NA Human Human +DTXSID3040279 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID3040279 TK.Half.Life NA 152.9 hours 1compartment NA NA Human Human +DTXSID3040279 Css NA 2.968 mg/L 3compartmentss NA 50% Human Human +DTXSID3040279 Css NA 17.99 mg/L 3compartmentss NA 95% Human Human +DTXSID3040279 Css NA 2.418 mg/L PBTK NA 50% Human Human +DTXSID3040279 Css NA 14.28 mg/L PBTK NA 95% Human Human +DTXSID3040279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040279 Fup 0.00595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040279 Vd NA 3.828 L/kg 1compartment NA NA Rat Human +DTXSID3040279 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID3040279 TK.Half.Life NA 21.63 hours 1compartment NA NA Rat Human +DTXSID3040279 Css NA 0.3876 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040279 Css NA 1.814 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040279 Css NA 0.3157 mg/L PBTK NA 50% Rat Human +DTXSID3040279 Css NA 1.494 mg/L PBTK NA 95% Rat Human +DTXSID3040487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040487 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3040487 Vd NA 0.6041 L/kg 1compartment NA NA Human Human +DTXSID3040487 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3040487 TK.Half.Life NA 3.909 hours 1compartment NA NA Human Human +DTXSID3040487 Css NA 0.7723 mg/L 3compartmentss NA 50% Human Human +DTXSID3040487 Css NA 5.031 mg/L 3compartmentss NA 95% Human Human +DTXSID3040487 Css NA 0.606 mg/L PBTK NA 50% Human Human +DTXSID3040487 Css NA 3.247 mg/L PBTK NA 95% Human Human +DTXSID3040487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040487 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3040487 Vd NA 0.638 L/kg 1compartment NA NA Rat Human +DTXSID3040487 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3040487 TK.Half.Life NA 1.407 hours 1compartment NA NA Rat Human +DTXSID3040487 Css NA 0.01939 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040487 Css NA 0.1339 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040487 Css NA 0.01479 mg/L PBTK NA 50% Rat Human +DTXSID3040487 Css NA 0.08478 mg/L PBTK NA 95% Rat Human +DTXSID3040643 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040643 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040643 Vd NA 2.456 L/kg 1compartment NA NA Human Human DTXSID3040643 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3040643 TK.Half.Life NA 3.172 hours 1compartment NA NA Human Human -DTXSID3040643 Css NA 0.07285 mg/L 3compartmentss NA 50% Human Human -DTXSID3040643 Css NA 0.5007 mg/L 3compartmentss NA 95% Human Human -DTXSID3040643 Css NA 0.06428 mg/L PBTK NA 50% Human Human -DTXSID3040643 Css NA 0.3957 mg/L PBTK NA 95% Human Human -DTXSID3040643 Clint NA 20.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040643 Fup NA 0.3319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040643 Vd NA 2.191 L/kg 1compartment NA NA Rat Human +DTXSID3040643 TK.Half.Life NA 4.232 hours 1compartment NA NA Human Human +DTXSID3040643 Css NA 0.1138 mg/L 3compartmentss NA 50% Human Human +DTXSID3040643 Css NA 0.7686 mg/L 3compartmentss NA 95% Human Human +DTXSID3040643 Css NA 0.092 mg/L PBTK NA 50% Human Human +DTXSID3040643 Css NA 0.5734 mg/L PBTK NA 95% Human Human +DTXSID3040643 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040643 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040643 Vd NA 2.098 L/kg 1compartment NA NA Rat Human DTXSID3040643 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3040643 TK.Half.Life NA 1.367 hours 1compartment NA NA Rat Human -DTXSID3040643 Css NA 0.03835 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040643 Css NA 0.2111 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040643 Css NA 0.03294 mg/L PBTK NA 50% Rat Human -DTXSID3040643 Css NA 0.1596 mg/L PBTK NA 95% Rat Human -DTXSID3040647 Clint NA 25.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3040643 TK.Half.Life NA 1.67 hours 1compartment NA NA Rat Human +DTXSID3040643 Css NA 0.0141 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040643 Css NA 0.07424 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040643 Css NA 0.01156 mg/L PBTK NA 50% Rat Human +DTXSID3040643 Css NA 0.05614 mg/L PBTK NA 95% Rat Human +DTXSID3040647 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3040647 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3040647 Vd NA 0.7683 L/kg 1compartment NA NA Human Human +DTXSID3040647 Vd NA 0.7675 L/kg 1compartment NA NA Human Human DTXSID3040647 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3040647 TK.Half.Life NA 0.5243 hours 1compartment NA NA Human Human -DTXSID3040647 Css NA 0.02018 mg/L 3compartmentss NA 50% Human Human -DTXSID3040647 Css NA 0.2552 mg/L 3compartmentss NA 95% Human Human -DTXSID3040647 Css NA 0.01666 mg/L PBTK NA 50% Human Human -DTXSID3040647 Css NA 0.1896 mg/L PBTK NA 95% Human Human -DTXSID3040647 Clint NA 25.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3040647 TK.Half.Life NA 4.969 hours 1compartment NA NA Human Human +DTXSID3040647 Css NA 0.7224 mg/L 3compartmentss NA 50% Human Human +DTXSID3040647 Css NA 4.926 mg/L 3compartmentss NA 95% Human Human +DTXSID3040647 Css NA 0.6059 mg/L PBTK NA 50% Human Human +DTXSID3040647 Css NA 3.247 mg/L PBTK NA 95% Human Human +DTXSID3040647 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3040647 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3040647 Vd NA 0.8087 L/kg 1compartment NA NA Rat Human +DTXSID3040647 Vd NA 0.8081 L/kg 1compartment NA NA Rat Human DTXSID3040647 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3040647 TK.Half.Life NA 0.2589 hours 1compartment NA NA Rat Human -DTXSID3040647 Css NA 0.01021 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040647 Css NA 0.1016 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040647 Css NA 0.00831 mg/L PBTK NA 50% Rat Human -DTXSID3040647 Css NA 0.07123 mg/L PBTK NA 95% Rat Human -DTXSID3040691 Clint NA 0.2308 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040691 Fup NA 0.2591 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040691 Vd NA 3.55 L/kg 1compartment NA NA Human Human -DTXSID3040691 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID3040691 TK.Half.Life NA 72.59 hours 1compartment NA NA Human Human -DTXSID3040691 Css NA 1.507 mg/L 3compartmentss NA 50% Human Human -DTXSID3040691 Css NA 6.557 mg/L 3compartmentss NA 95% Human Human -DTXSID3040691 Css NA 1.651 mg/L PBTK NA 50% Human Human -DTXSID3040691 Css NA 5.419 mg/L PBTK NA 95% Human Human -DTXSID3040691 Clint NA 0.2308 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040691 Fup NA 0.2591 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040691 Vd NA 3.471 L/kg 1compartment NA NA Rat Human -DTXSID3040691 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID3040691 TK.Half.Life NA 25.16 hours 1compartment NA NA Rat Human -DTXSID3040691 Css NA 0.4865 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040691 Css NA 1.912 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040691 Css NA 0.5303 mg/L PBTK NA 50% Rat Human -DTXSID3040691 Css NA 1.437 mg/L PBTK NA 95% Rat Human -DTXSID3040699 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040699 Fup NA 0.004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040699 Vd NA 0.2588 L/kg 1compartment NA NA Human Human -DTXSID3040699 Days.Css NA 107 Days PBTK NA NA Human Human -DTXSID3040699 TK.Half.Life NA 421.1 hours 1compartment NA NA Human Human -DTXSID3040699 Css NA 282.4 mg/L 3compartmentss NA 50% Human Human -DTXSID3040699 Css NA 1096 mg/L 3compartmentss NA 95% Human Human -DTXSID3040699 Css NA 166.2 mg/L PBTK NA 50% Human Human -DTXSID3040699 Css NA 628.1 mg/L PBTK NA 95% Human Human -DTXSID3040699 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040699 Fup NA 0.004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040699 Vd NA 0.223 L/kg 1compartment NA NA Rat Human -DTXSID3040699 Days.Css NA 27 Days PBTK NA NA Rat Human -DTXSID3040699 TK.Half.Life NA 123.1 hours 1compartment NA NA Rat Human -DTXSID3040699 Css NA 80.24 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040699 Css NA 256.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040699 Css NA 43.81 mg/L PBTK NA 50% Rat Human -DTXSID3040699 Css NA 139 mg/L PBTK NA 95% Rat Human -DTXSID3040720 Clint NA 1.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040720 Fup NA 0.1256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040720 Vd NA 0.7051 L/kg 1compartment NA NA Human Human -DTXSID3040720 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3040720 TK.Half.Life NA 14.1 hours 1compartment NA NA Human Human -DTXSID3040720 Css NA 2.922 mg/L 3compartmentss NA 50% Human Human -DTXSID3040720 Css NA 15.59 mg/L 3compartmentss NA 95% Human Human -DTXSID3040720 Css NA 1.885 mg/L PBTK NA 50% Human Human -DTXSID3040720 Css NA 9.398 mg/L PBTK NA 95% Human Human -DTXSID3040720 Clint NA 1.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040720 Fup NA 0.1256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040720 Vd NA 0.5822 L/kg 1compartment NA NA Rat Human +DTXSID3040647 TK.Half.Life NA 1.782 hours 1compartment NA NA Rat Human +DTXSID3040647 Css NA 0.01795 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040647 Css NA 0.1299 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040647 Css NA 0.01476 mg/L PBTK NA 50% Rat Human +DTXSID3040647 Css NA 0.08484 mg/L PBTK NA 95% Rat Human +DTXSID3040691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040691 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040691 Vd NA 2.82 L/kg 1compartment NA NA Human Human +DTXSID3040691 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3040691 TK.Half.Life NA 9.032 hours 1compartment NA NA Human Human +DTXSID3040691 Css NA 0.2839 mg/L 3compartmentss NA 50% Human Human +DTXSID3040691 Css NA 1.833 mg/L 3compartmentss NA 95% Human Human +DTXSID3040691 Css NA 0.2068 mg/L PBTK NA 50% Human Human +DTXSID3040691 Css NA 1.27 mg/L PBTK NA 95% Human Human +DTXSID3040691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040691 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040691 Vd NA 2.141 L/kg 1compartment NA NA Rat Human +DTXSID3040691 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3040691 TK.Half.Life NA 2.05 hours 1compartment NA NA Rat Human +DTXSID3040691 Css NA 0.036 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040691 Css NA 0.183 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040691 Css NA 0.02612 mg/L PBTK NA 50% Rat Human +DTXSID3040691 Css NA 0.127 mg/L PBTK NA 95% Rat Human +DTXSID3040693 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040693 Fup 0.892 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040693 Vd NA 2.139 L/kg 1compartment NA NA Human Human +DTXSID3040693 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3040693 TK.Half.Life NA 15.52 hours 1compartment NA NA Human Human +DTXSID3040693 Css NA 0.7201 mg/L 3compartmentss NA 50% Human Human +DTXSID3040693 Css NA 4.506 mg/L 3compartmentss NA 95% Human Human +DTXSID3040693 Css NA 0.7482 mg/L PBTK NA 50% Human Human +DTXSID3040693 Css NA 3.293 mg/L PBTK NA 95% Human Human +DTXSID3040693 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040693 Fup 0.892 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040693 Vd NA 2.177 L/kg 1compartment NA NA Rat Human +DTXSID3040693 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3040693 TK.Half.Life NA 5.382 hours 1compartment NA NA Rat Human +DTXSID3040693 Css NA 0.04158 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040693 Css NA 0.2844 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040693 Css NA 0.04439 mg/L PBTK NA 50% Rat Human +DTXSID3040693 Css NA 0.1925 mg/L PBTK NA 95% Rat Human +DTXSID3040699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040699 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040699 Vd NA 0.3732 L/kg 1compartment NA NA Human Human +DTXSID3040699 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3040699 TK.Half.Life NA 5.696 hours 1compartment NA NA Human Human +DTXSID3040699 Css NA 2.6 mg/L 3compartmentss NA 50% Human Human +DTXSID3040699 Css NA 25.87 mg/L 3compartmentss NA 95% Human Human +DTXSID3040699 Css NA 1.566 mg/L PBTK NA 50% Human Human +DTXSID3040699 Css NA 15.34 mg/L PBTK NA 95% Human Human +DTXSID3040699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040699 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040699 Vd NA 0.3091 L/kg 1compartment NA NA Rat Human +DTXSID3040699 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3040699 TK.Half.Life NA 3.114 hours 1compartment NA NA Rat Human +DTXSID3040699 Css NA 0.3486 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040699 Css NA 2.841 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040699 Css NA 0.2012 mg/L PBTK NA 50% Rat Human +DTXSID3040699 Css NA 1.617 mg/L PBTK NA 95% Rat Human +DTXSID3040720 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040720 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040720 Vd NA 0.9251 L/kg 1compartment NA NA Human Human +DTXSID3040720 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3040720 TK.Half.Life NA 3.827 hours 1compartment NA NA Human Human +DTXSID3040720 Css NA 0.4227 mg/L 3compartmentss NA 50% Human Human +DTXSID3040720 Css NA 2.502 mg/L 3compartmentss NA 95% Human Human +DTXSID3040720 Css NA 0.2902 mg/L PBTK NA 50% Human Human +DTXSID3040720 Css NA 1.597 mg/L PBTK NA 95% Human Human +DTXSID3040720 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040720 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040720 Vd NA 0.7628 L/kg 1compartment NA NA Rat Human DTXSID3040720 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3040720 TK.Half.Life NA 5.613 hours 1compartment NA NA Rat Human -DTXSID3040720 Css NA 1.233 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040720 Css NA 5.162 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040720 Css NA 0.7485 mg/L PBTK NA 50% Rat Human -DTXSID3040720 Css NA 2.89 mg/L PBTK NA 95% Rat Human -DTXSID3040722 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040722 Fup NA 0.1007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040722 Vd NA 2.774 L/kg 1compartment NA NA Human Human -DTXSID3040722 Days.Css NA 233 Days PBTK NA NA Human Human -DTXSID3040722 TK.Half.Life NA 932.5 hours 1compartment NA NA Human Human -DTXSID3040722 Css NA 41.02 mg/L 3compartmentss NA 50% Human Human -DTXSID3040722 Css NA 124.3 mg/L 3compartmentss NA 95% Human Human -DTXSID3040722 Css NA 28.52 mg/L PBTK NA 50% Human Human -DTXSID3040722 Css NA 79.79 mg/L PBTK NA 95% Human Human -DTXSID3040722 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040722 Fup NA 0.1007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040722 Vd NA 2.086 L/kg 1compartment NA NA Rat Human -DTXSID3040722 Days.Css NA 58 Days PBTK NA NA Rat Human -DTXSID3040722 TK.Half.Life NA 91.69 hours 1compartment NA NA Rat Human -DTXSID3040722 Css NA 11.15 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040722 Css NA 27.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040722 Css NA 7.404 mg/L PBTK NA 50% Rat Human -DTXSID3040722 Css NA 16.25 mg/L PBTK NA 95% Rat Human -DTXSID3040724 Clint NA 19.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040724 Fup NA 0.4719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040724 Vd NA 3.163 L/kg 1compartment NA NA Human Human +DTXSID3040720 TK.Half.Life NA 1.779 hours 1compartment NA NA Rat Human +DTXSID3040720 Css NA 0.05077 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040720 Css NA 0.2146 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040720 Css NA 0.03436 mg/L PBTK NA 50% Rat Human +DTXSID3040720 Css NA 0.1325 mg/L PBTK NA 95% Rat Human +DTXSID3040722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040722 Fup 0.0541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040722 Vd NA 2.909 L/kg 1compartment NA NA Human Human +DTXSID3040722 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3040722 TK.Half.Life NA 31.94 hours 1compartment NA NA Human Human +DTXSID3040722 Css NA 1.335 mg/L 3compartmentss NA 50% Human Human +DTXSID3040722 Css NA 8.457 mg/L 3compartmentss NA 95% Human Human +DTXSID3040722 Css NA 0.9194 mg/L PBTK NA 50% Human Human +DTXSID3040722 Css NA 5.642 mg/L PBTK NA 95% Human Human +DTXSID3040722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040722 Fup 0.0541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040722 Vd NA 2.181 L/kg 1compartment NA NA Rat Human +DTXSID3040722 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3040722 TK.Half.Life NA 5.805 hours 1compartment NA NA Rat Human +DTXSID3040722 Css NA 0.1689 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040722 Css NA 0.9311 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040722 Css NA 0.1154 mg/L PBTK NA 50% Rat Human +DTXSID3040722 Css NA 0.612 mg/L PBTK NA 95% Rat Human +DTXSID3040724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040724 Fup 0.487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040724 Vd NA 1.944 L/kg 1compartment NA NA Human Human DTXSID3040724 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3040724 TK.Half.Life NA 2.557 hours 1compartment NA NA Human Human -DTXSID3040724 Css NA 0.03046 mg/L 3compartmentss NA 50% Human Human -DTXSID3040724 Css NA 0.304 mg/L 3compartmentss NA 95% Human Human -DTXSID3040724 Css NA 0.03608 mg/L PBTK NA 50% Human Human -DTXSID3040724 Css NA 0.2651 mg/L PBTK NA 95% Human Human -DTXSID3040724 Clint NA 19.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040724 Fup NA 0.4719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040724 Vd NA 3.205 L/kg 1compartment NA NA Rat Human +DTXSID3040724 TK.Half.Life NA 3.141 hours 1compartment NA NA Human Human +DTXSID3040724 Css NA 0.1079 mg/L 3compartmentss NA 50% Human Human +DTXSID3040724 Css NA 0.8685 mg/L 3compartmentss NA 95% Human Human +DTXSID3040724 Css NA 0.1033 mg/L PBTK NA 50% Human Human +DTXSID3040724 Css NA 0.6654 mg/L PBTK NA 95% Human Human +DTXSID3040724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040724 Fup 0.487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040724 Vd NA 1.957 L/kg 1compartment NA NA Rat Human DTXSID3040724 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3040724 TK.Half.Life NA 1.402 hours 1compartment NA NA Rat Human -DTXSID3040724 Css NA 0.01558 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040724 Css NA 0.1265 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040724 Css NA 0.01835 mg/L PBTK NA 50% Rat Human -DTXSID3040724 Css NA 0.1065 mg/L PBTK NA 95% Rat Human +DTXSID3040724 TK.Half.Life NA 1.785 hours 1compartment NA NA Rat Human +DTXSID3040724 Css NA 0.01176 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040724 Css NA 0.08175 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040724 Css NA 0.01174 mg/L PBTK NA 50% Rat Human +DTXSID3040724 Css NA 0.05795 mg/L PBTK NA 95% Rat Human DTXSID3040726 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3040726 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040726 Vd NA 1.137 L/kg 1compartment NA NA Human Human +DTXSID3040726 Vd NA 0.9285 L/kg 1compartment NA NA Human Human DTXSID3040726 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3040726 TK.Half.Life NA 1.407 hours 1compartment NA NA Human Human -DTXSID3040726 Css NA 0.1025 mg/L 3compartmentss NA 50% Human Human -DTXSID3040726 Css NA 0.9342 mg/L 3compartmentss NA 95% Human Human -DTXSID3040726 Css NA 0.09203 mg/L PBTK NA 50% Human Human -DTXSID3040726 Css NA 0.6787 mg/L PBTK NA 95% Human Human +DTXSID3040726 TK.Half.Life NA 1.151 hours 1compartment NA NA Human Human +DTXSID3040726 Css NA 0.1016 mg/L 3compartmentss NA 50% Human Human +DTXSID3040726 Css NA 0.948 mg/L 3compartmentss NA 95% Human Human +DTXSID3040726 Css NA 0.08743 mg/L PBTK NA 50% Human Human +DTXSID3040726 Css NA 0.6715 mg/L PBTK NA 95% Human Human DTXSID3040726 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3040726 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040726 Vd NA 1.111 L/kg 1compartment NA NA Rat Human +DTXSID3040726 Vd NA 0.943 L/kg 1compartment NA NA Rat Human DTXSID3040726 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3040726 TK.Half.Life NA 0.715 hours 1compartment NA NA Rat Human -DTXSID3040726 Css NA 0.04616 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040726 Css NA 0.3379 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040726 Css NA 0.04172 mg/L PBTK NA 50% Rat Human -DTXSID3040726 Css NA 0.2225 mg/L PBTK NA 95% Rat Human -DTXSID3040728 Clint NA 21.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040728 Fup NA 0.3237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040728 Vd NA 0.3901 L/kg 1compartment NA NA Human Human -DTXSID3040728 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3040728 TK.Half.Life NA 0.51 hours 1compartment NA NA Human Human -DTXSID3040728 Css NA 0.0704 mg/L 3compartmentss NA 50% Human Human -DTXSID3040728 Css NA 0.5049 mg/L 3compartmentss NA 95% Human Human -DTXSID3040728 Css NA 0.0478 mg/L PBTK NA 50% Human Human -DTXSID3040728 Css NA 0.3265 mg/L PBTK NA 95% Human Human -DTXSID3040728 Clint NA 21.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040728 Fup NA 0.3237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040728 Vd NA 0.3885 L/kg 1compartment NA NA Rat Human +DTXSID3040726 TK.Half.Life NA 0.6118 hours 1compartment NA NA Rat Human +DTXSID3040726 Css NA 0.01066 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040726 Css NA 0.07857 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040726 Css NA 0.009506 mg/L PBTK NA 50% Rat Human +DTXSID3040726 Css NA 0.05106 mg/L PBTK NA 95% Rat Human +DTXSID3040728 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040728 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040728 Vd NA 0.9239 L/kg 1compartment NA NA Human Human +DTXSID3040728 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3040728 TK.Half.Life NA 9.704 hours 1compartment NA NA Human Human +DTXSID3040728 Css NA 1.128 mg/L 3compartmentss NA 50% Human Human +DTXSID3040728 Css NA 7.807 mg/L 3compartmentss NA 95% Human Human +DTXSID3040728 Css NA 0.9439 mg/L PBTK NA 50% Human Human +DTXSID3040728 Css NA 4.992 mg/L PBTK NA 95% Human Human +DTXSID3040728 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040728 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040728 Vd NA 0.9039 L/kg 1compartment NA NA Rat Human DTXSID3040728 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3040728 TK.Half.Life NA 0.2661 hours 1compartment NA NA Rat Human -DTXSID3040728 Css NA 0.03811 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040728 Css NA 0.2161 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040728 Css NA 0.02466 mg/L PBTK NA 50% Rat Human -DTXSID3040728 Css NA 0.1302 mg/L PBTK NA 95% Rat Human -DTXSID3040770 Clint NA 54.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040770 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040770 Vd NA 3.024 L/kg 1compartment NA NA Human Human -DTXSID3040770 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3040770 TK.Half.Life NA 27.44 hours 1compartment NA NA Human Human -DTXSID3040770 Css NA 1.091 mg/L 3compartmentss NA 50% Human Human -DTXSID3040770 Css NA 6.778 mg/L 3compartmentss NA 95% Human Human -DTXSID3040770 Css NA 0.7522 mg/L PBTK NA 50% Human Human -DTXSID3040770 Css NA 4.493 mg/L PBTK NA 95% Human Human -DTXSID3040770 Clint NA 54.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040770 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040770 Vd NA 2.263 L/kg 1compartment NA NA Rat Human -DTXSID3040770 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3040770 TK.Half.Life NA 4.501 hours 1compartment NA NA Rat Human -DTXSID3040770 Css NA 0.6061 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040770 Css NA 3.189 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040770 Css NA 0.3972 mg/L PBTK NA 50% Rat Human -DTXSID3040770 Css NA 2.026 mg/L PBTK NA 95% Rat Human +DTXSID3040728 TK.Half.Life NA 3.197 hours 1compartment NA NA Rat Human +DTXSID3040728 Css NA 0.06701 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040728 Css NA 0.4545 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040728 Css NA 0.05616 mg/L PBTK NA 50% Rat Human +DTXSID3040728 Css NA 0.2797 mg/L PBTK NA 95% Rat Human +DTXSID3040770 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040770 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040770 Vd NA 2.941 L/kg 1compartment NA NA Human Human +DTXSID3040770 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID3040770 TK.Half.Life NA 65.89 hours 1compartment NA NA Human Human +DTXSID3040770 Css NA 2.851 mg/L 3compartmentss NA 50% Human Human +DTXSID3040770 Css NA 19.02 mg/L 3compartmentss NA 95% Human Human +DTXSID3040770 Css NA 1.94 mg/L PBTK NA 50% Human Human +DTXSID3040770 Css NA 12.57 mg/L PBTK NA 95% Human Human +DTXSID3040770 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040770 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040770 Vd NA 2.2 L/kg 1compartment NA NA Rat Human +DTXSID3040770 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID3040770 TK.Half.Life NA 11.12 hours 1compartment NA NA Rat Human +DTXSID3040770 Css NA 0.3713 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040770 Css NA 2.261 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040770 Css NA 0.2498 mg/L PBTK NA 50% Rat Human +DTXSID3040770 Css NA 1.478 mg/L PBTK NA 95% Rat Human DTXSID3040776 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3040776 Fup 5.73e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3040776 Vd NA 0.1592 L/kg 1compartment NA NA Human Human -DTXSID3040776 Days.Css NA 2862 Days PBTK NA NA Human Human +DTXSID3040776 Days.Css NA 2844 Days PBTK NA NA Human Human DTXSID3040776 TK.Half.Life NA 10300 hours 1compartment NA NA Human Human -DTXSID3040776 Css NA 111.5 mg/L 3compartmentss NA 50% Human Human -DTXSID3040776 Css NA 945.8 mg/L 3compartmentss NA 95% Human Human -DTXSID3040776 Css NA 64.63 mg/L PBTK NA 50% Human Human -DTXSID3040776 Css NA 549.4 mg/L PBTK NA 95% Human Human +DTXSID3040776 Css NA 66.84 mg/L 3compartmentss NA 50% Human Human +DTXSID3040776 Css NA 575.8 mg/L 3compartmentss NA 95% Human Human +DTXSID3040776 Css NA 38.89 mg/L PBTK NA 50% Human Human +DTXSID3040776 Css NA 331.9 mg/L PBTK NA 95% Human Human DTXSID3040776 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3040776 Fup 5.73e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3040776 Vd NA 0.1578 L/kg 1compartment NA NA Rat Human -DTXSID3040776 Days.Css NA 958 Days PBTK NA NA Rat Human +DTXSID3040776 Days.Css NA 651 Days PBTK NA NA Rat Human DTXSID3040776 TK.Half.Life NA 3480 hours 1compartment NA NA Rat Human -DTXSID3040776 Css NA 30.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040776 Css NA 268 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040776 Css NA 16.49 mg/L PBTK NA 50% Rat Human -DTXSID3040776 Css NA 144.8 mg/L PBTK NA 95% Rat Human -DTXSID3040801 Clint NA 10.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040801 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3040801 Vd NA 1.551 L/kg 1compartment NA NA Human Human -DTXSID3040801 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID3040801 TK.Half.Life NA 44.18 hours 1compartment NA NA Human Human -DTXSID3040801 Css NA 4.816 mg/L 3compartmentss NA 50% Human Human -DTXSID3040801 Css NA 40.27 mg/L 3compartmentss NA 95% Human Human -DTXSID3040801 Css NA 3.001 mg/L PBTK NA 50% Human Human -DTXSID3040801 Css NA 24.16 mg/L PBTK NA 95% Human Human -DTXSID3040801 Clint NA 10.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040801 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3040801 Vd NA 1.144 L/kg 1compartment NA NA Rat Human -DTXSID3040801 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3040801 TK.Half.Life NA 16.52 hours 1compartment NA NA Rat Human -DTXSID3040801 Css NA 2.676 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040801 Css NA 18.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040801 Css NA 1.563 mg/L PBTK NA 50% Rat Human -DTXSID3040801 Css NA 10.07 mg/L PBTK NA 95% Rat Human +DTXSID3040776 Css NA 0.3936 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040776 Css NA 3.882 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040776 Css NA 0.2144 mg/L PBTK NA 50% Rat Human +DTXSID3040776 Css NA 2.111 mg/L PBTK NA 95% Rat Human +DTXSID3040801 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040801 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3040801 Vd NA 1.755 L/kg 1compartment NA NA Human Human +DTXSID3040801 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3040801 TK.Half.Life NA 20.92 hours 1compartment NA NA Human Human +DTXSID3040801 Css NA 1.832 mg/L 3compartmentss NA 50% Human Human +DTXSID3040801 Css NA 16.15 mg/L 3compartmentss NA 95% Human Human +DTXSID3040801 Css NA 1.151 mg/L PBTK NA 50% Human Human +DTXSID3040801 Css NA 9.648 mg/L PBTK NA 95% Human Human +DTXSID3040801 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040801 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3040801 Vd NA 1.298 L/kg 1compartment NA NA Rat Human +DTXSID3040801 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3040801 TK.Half.Life NA 7.368 hours 1compartment NA NA Rat Human +DTXSID3040801 Css NA 0.2414 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040801 Css NA 1.659 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040801 Css NA 0.1482 mg/L PBTK NA 50% Rat Human +DTXSID3040801 Css NA 0.9869 mg/L PBTK NA 95% Rat Human DTXSID3040980 Clint 7.658 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3040980 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3040980 Vd NA 0.9817 L/kg 1compartment NA NA Human Human +DTXSID3040980 Vd NA 1.059 L/kg 1compartment NA NA Human Human DTXSID3040980 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3040980 TK.Half.Life NA 3.524 hours 1compartment NA NA Human Human -DTXSID3040980 Css NA 0.3695 mg/L 3compartmentss NA 50% Human Human -DTXSID3040980 Css NA 2.292 mg/L 3compartmentss NA 95% Human Human -DTXSID3040980 Css NA 0.2546 mg/L PBTK NA 50% Human Human -DTXSID3040980 Css NA 1.468 mg/L PBTK NA 95% Human Human +DTXSID3040980 TK.Half.Life NA 3.842 hours 1compartment NA NA Human Human +DTXSID3040980 Css NA 0.3094 mg/L 3compartmentss NA 50% Human Human +DTXSID3040980 Css NA 2.083 mg/L 3compartmentss NA 95% Human Human +DTXSID3040980 Css NA 0.2158 mg/L PBTK NA 50% Human Human +DTXSID3040980 Css NA 1.345 mg/L PBTK NA 95% Human Human DTXSID3040980 Clint 7.658 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3040980 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3040980 Vd NA 0.8156 L/kg 1compartment NA NA Rat Human +DTXSID3040980 Vd NA 0.8706 L/kg 1compartment NA NA Rat Human DTXSID3040980 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3040980 TK.Half.Life NA 1.65 hours 1compartment NA NA Rat Human -DTXSID3040980 Css NA 0.1944 mg/L 3compartmentss NA 50% Rat Human -DTXSID3040980 Css NA 0.8751 mg/L 3compartmentss NA 95% Rat Human -DTXSID3040980 Css NA 0.1275 mg/L PBTK NA 50% Rat Human -DTXSID3040980 Css NA 0.5348 mg/L PBTK NA 95% Rat Human +DTXSID3040980 TK.Half.Life NA 1.758 hours 1compartment NA NA Rat Human +DTXSID3040980 Css NA 0.01444 mg/L 3compartmentss NA 50% Rat Human +DTXSID3040980 Css NA 0.1003 mg/L 3compartmentss NA 95% Rat Human +DTXSID3040980 Css NA 0.00984 mg/L PBTK NA 50% Rat Human +DTXSID3040980 Css NA 0.06284 mg/L PBTK NA 95% Rat Human DTXSID3041035 Clint 146 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3041035 Fup 0.141 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3041035 Vd NA 2.626 L/kg 1compartment NA NA Human Human +DTXSID3041035 Vd NA 2.81 L/kg 1compartment NA NA Human Human DTXSID3041035 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041035 TK.Half.Life NA 3.318 hours 1compartment NA NA Human Human -DTXSID3041035 Css NA 0.05668 mg/L 3compartmentss NA 50% Human Human -DTXSID3041035 Css NA 0.3749 mg/L 3compartmentss NA 95% Human Human -DTXSID3041035 Css NA 0.0402 mg/L PBTK NA 50% Human Human -DTXSID3041035 Css NA 0.2586 mg/L PBTK NA 95% Human Human +DTXSID3041035 TK.Half.Life NA 4.011 hours 1compartment NA NA Human Human +DTXSID3041035 Css NA 0.07218 mg/L 3compartmentss NA 50% Human Human +DTXSID3041035 Css NA 0.4928 mg/L 3compartmentss NA 95% Human Human +DTXSID3041035 Css NA 0.05106 mg/L PBTK NA 50% Human Human +DTXSID3041035 Css NA 0.331 mg/L PBTK NA 95% Human Human DTXSID3041035 Clint 146 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3041035 Fup 0.141 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3041035 Vd NA 1.985 L/kg 1compartment NA NA Rat Human +DTXSID3041035 Vd NA 2.119 L/kg 1compartment NA NA Rat Human DTXSID3041035 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041035 TK.Half.Life NA 0.9709 hours 1compartment NA NA Rat Human -DTXSID3041035 Css NA 0.03167 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041035 Css NA 0.1762 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041035 Css NA 0.02158 mg/L PBTK NA 50% Rat Human -DTXSID3041035 Css NA 0.1158 mg/L PBTK NA 95% Rat Human -DTXSID3041085 Clint NA 6.419 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3041035 TK.Half.Life NA 1.082 hours 1compartment NA NA Rat Human +DTXSID3041035 Css NA 0.009461 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041035 Css NA 0.05361 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041035 Css NA 0.006677 mg/L PBTK NA 50% Rat Human +DTXSID3041035 Css NA 0.03649 mg/L PBTK NA 95% Rat Human +DTXSID3041085 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3041085 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3041085 Vd NA 0.6924 L/kg 1compartment NA NA Human Human DTXSID3041085 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041085 TK.Half.Life NA 0.8194 hours 1compartment NA NA Human Human -DTXSID3041085 Css NA 0.08484 mg/L 3compartmentss NA 50% Human Human -DTXSID3041085 Css NA 0.7228 mg/L 3compartmentss NA 95% Human Human -DTXSID3041085 Css NA 0.0787 mg/L PBTK NA 50% Human Human -DTXSID3041085 Css NA 0.5301 mg/L PBTK NA 95% Human Human -DTXSID3041085 Clint NA 6.419 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3041085 TK.Half.Life NA 5.986 hours 1compartment NA NA Human Human +DTXSID3041085 Css NA 0.8248 mg/L 3compartmentss NA 50% Human Human +DTXSID3041085 Css NA 4.162 mg/L 3compartmentss NA 95% Human Human +DTXSID3041085 Css NA 0.8248 mg/L PBTK NA 50% Human Human +DTXSID3041085 Css NA 4.162 mg/L PBTK NA 95% Human Human +DTXSID3041085 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3041085 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3041085 Vd NA 0.7241 L/kg 1compartment NA NA Rat Human DTXSID3041085 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041085 TK.Half.Life NA 0.4797 hours 1compartment NA NA Rat Human -DTXSID3041085 Css NA 0.03896 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041085 Css NA 0.3193 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041085 Css NA 0.03594 mg/L PBTK NA 50% Rat Human -DTXSID3041085 Css NA 0.2108 mg/L PBTK NA 95% Rat Human -DTXSID3041247 Clint NA 5.259 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041247 Fup NA 0.1146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041247 Vd NA 2.062 L/kg 1compartment NA NA Human Human -DTXSID3041247 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3041247 TK.Half.Life NA 19.83 hours 1compartment NA NA Human Human -DTXSID3041247 Css NA 1.298 mg/L 3compartmentss NA 50% Human Human -DTXSID3041247 Css NA 7.307 mg/L 3compartmentss NA 95% Human Human -DTXSID3041247 Css NA 0.8906 mg/L PBTK NA 50% Human Human -DTXSID3041247 Css NA 4.627 mg/L PBTK NA 95% Human Human -DTXSID3041247 Clint NA 5.259 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041247 Fup NA 0.1146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041247 Vd NA 1.565 L/kg 1compartment NA NA Rat Human -DTXSID3041247 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041247 TK.Half.Life NA 6.102 hours 1compartment NA NA Rat Human -DTXSID3041247 Css NA 0.6666 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041247 Css NA 2.841 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041247 Css NA 0.4338 mg/L PBTK NA 50% Rat Human -DTXSID3041247 Css NA 1.718 mg/L PBTK NA 95% Rat Human -DTXSID3041293 Clint NA 29.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041293 Fup NA 0.6461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041293 Vd NA 3.544 L/kg 1compartment NA NA Human Human +DTXSID3041085 TK.Half.Life NA 2.075 hours 1compartment NA NA Rat Human +DTXSID3041085 Css NA 0.04625 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041085 Css NA 0.2153 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041085 Css NA 0.04789 mg/L PBTK NA 50% Rat Human +DTXSID3041085 Css NA 0.223 mg/L PBTK NA 95% Rat Human +DTXSID3041241 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041241 Fup 0.736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041241 Vd NA 1.035 L/kg 1compartment NA NA Human Human +DTXSID3041241 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3041241 TK.Half.Life NA 9.406 hours 1compartment NA NA Human Human +DTXSID3041241 Css NA 0.9748 mg/L 3compartmentss NA 50% Human Human +DTXSID3041241 Css NA 6.46 mg/L 3compartmentss NA 95% Human Human +DTXSID3041241 Css NA 0.8473 mg/L PBTK NA 50% Human Human +DTXSID3041241 Css NA 4.212 mg/L PBTK NA 95% Human Human +DTXSID3041241 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041241 Fup 0.736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041241 Vd NA 0.9888 L/kg 1compartment NA NA Rat Human +DTXSID3041241 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3041241 TK.Half.Life NA 2.986 hours 1compartment NA NA Rat Human +DTXSID3041241 Css NA 0.05789 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041241 Css NA 0.3735 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041241 Css NA 0.05059 mg/L PBTK NA 50% Rat Human +DTXSID3041241 Css NA 0.2344 mg/L PBTK NA 95% Rat Human +DTXSID3041247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041247 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041247 Vd NA 2.643 L/kg 1compartment NA NA Human Human +DTXSID3041247 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3041247 TK.Half.Life NA 46.18 hours 1compartment NA NA Human Human +DTXSID3041247 Css NA 2.383 mg/L 3compartmentss NA 50% Human Human +DTXSID3041247 Css NA 17.79 mg/L 3compartmentss NA 95% Human Human +DTXSID3041247 Css NA 1.59 mg/L PBTK NA 50% Human Human +DTXSID3041247 Css NA 11.55 mg/L PBTK NA 95% Human Human +DTXSID3041247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041247 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041247 Vd NA 1.971 L/kg 1compartment NA NA Rat Human +DTXSID3041247 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3041247 TK.Half.Life NA 10.23 hours 1compartment NA NA Rat Human +DTXSID3041247 Css NA 0.3118 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041247 Css NA 1.906 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041247 Css NA 0.2036 mg/L PBTK NA 50% Rat Human +DTXSID3041247 Css NA 1.217 mg/L PBTK NA 95% Rat Human +DTXSID3041293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041293 Fup 0.442 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041293 Vd NA 1.172 L/kg 1compartment NA NA Human Human DTXSID3041293 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041293 TK.Half.Life NA 2.089 hours 1compartment NA NA Human Human -DTXSID3041293 Css NA 0.01641 mg/L 3compartmentss NA 50% Human Human -DTXSID3041293 Css NA 0.2079 mg/L 3compartmentss NA 95% Human Human -DTXSID3041293 Css NA 0.02012 mg/L PBTK NA 50% Human Human -DTXSID3041293 Css NA 0.182 mg/L PBTK NA 95% Human Human -DTXSID3041293 Clint NA 29.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041293 Fup NA 0.6461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041293 Vd NA 3.587 L/kg 1compartment NA NA Rat Human +DTXSID3041293 TK.Half.Life NA 1.239 hours 1compartment NA NA Human Human +DTXSID3041293 Css NA 0.04466 mg/L 3compartmentss NA 50% Human Human +DTXSID3041293 Css NA 0.3538 mg/L 3compartmentss NA 95% Human Human +DTXSID3041293 Css NA 0.03535 mg/L PBTK NA 50% Human Human +DTXSID3041293 Css NA 0.253 mg/L PBTK NA 95% Human Human +DTXSID3041293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041293 Fup 0.442 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041293 Vd NA 1.02 L/kg 1compartment NA NA Rat Human DTXSID3041293 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041293 TK.Half.Life NA 1.057 hours 1compartment NA NA Rat Human -DTXSID3041293 Css NA 0.008074 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041293 Css NA 0.09333 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041293 Css NA 0.01009 mg/L PBTK NA 50% Rat Human -DTXSID3041293 Css NA 0.0745 mg/L PBTK NA 95% Rat Human -DTXSID3041299 Clint NA 0.1277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041299 Fup NA 0.1168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041299 Vd NA 2.46 L/kg 1compartment NA NA Human Human -DTXSID3041299 Days.Css NA 67 Days PBTK NA NA Human Human -DTXSID3041299 TK.Half.Life NA 304 hours 1compartment NA NA Human Human -DTXSID3041299 Css NA 15.42 mg/L 3compartmentss NA 50% Human Human -DTXSID3041299 Css NA 51.89 mg/L 3compartmentss NA 95% Human Human -DTXSID3041299 Css NA 10.71 mg/L PBTK NA 50% Human Human -DTXSID3041299 Css NA 32.58 mg/L PBTK NA 95% Human Human -DTXSID3041299 Clint NA 0.1277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041299 Fup NA 0.1168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041299 Vd NA 1.859 L/kg 1compartment NA NA Rat Human -DTXSID3041299 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID3041299 TK.Half.Life NA 44.49 hours 1compartment NA NA Rat Human -DTXSID3041299 Css NA 4.932 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041299 Css NA 13.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041299 Css NA 3.252 mg/L PBTK NA 50% Rat Human -DTXSID3041299 Css NA 7.842 mg/L PBTK NA 95% Rat Human -DTXSID3041328 Clint NA 4.528 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041328 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041328 Vd NA 2.825 L/kg 1compartment NA NA Human Human -DTXSID3041328 Days.Css NA 47 Days PBTK NA NA Human Human -DTXSID3041328 TK.Half.Life NA 226.7 hours 1compartment NA NA Human Human -DTXSID3041328 Css NA 11.07 mg/L 3compartmentss NA 50% Human Human -DTXSID3041328 Css NA 69.36 mg/L 3compartmentss NA 95% Human Human -DTXSID3041328 Css NA 7.519 mg/L PBTK NA 50% Human Human -DTXSID3041328 Css NA 44.67 mg/L PBTK NA 95% Human Human -DTXSID3041328 Clint NA 4.528 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041328 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041328 Vd NA 2.111 L/kg 1compartment NA NA Rat Human -DTXSID3041328 Days.Css NA 25 Days PBTK NA NA Rat Human -DTXSID3041328 TK.Half.Life NA 41.14 hours 1compartment NA NA Rat Human -DTXSID3041328 Css NA 6.074 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041328 Css NA 29.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041328 Css NA 3.923 mg/L PBTK NA 50% Rat Human -DTXSID3041328 Css NA 18.37 mg/L PBTK NA 95% Rat Human -DTXSID3041370 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041370 Fup NA 0.9663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041370 Vd NA 0.7903 L/kg 1compartment NA NA Human Human +DTXSID3041293 TK.Half.Life NA 0.5382 hours 1compartment NA NA Rat Human +DTXSID3041293 Css NA 0.005418 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041293 Css NA 0.03661 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041293 Css NA 0.00438 mg/L PBTK NA 50% Rat Human +DTXSID3041293 Css NA 0.02548 mg/L PBTK NA 95% Rat Human +DTXSID3041299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041299 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041299 Vd NA 2.432 L/kg 1compartment NA NA Human Human +DTXSID3041299 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3041299 TK.Half.Life NA 6.883 hours 1compartment NA NA Human Human +DTXSID3041299 Css NA 0.2482 mg/L 3compartmentss NA 50% Human Human +DTXSID3041299 Css NA 1.584 mg/L 3compartmentss NA 95% Human Human +DTXSID3041299 Css NA 0.1778 mg/L PBTK NA 50% Human Human +DTXSID3041299 Css NA 1.066 mg/L PBTK NA 95% Human Human +DTXSID3041299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041299 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041299 Vd NA 1.849 L/kg 1compartment NA NA Rat Human +DTXSID3041299 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3041299 TK.Half.Life NA 1.953 hours 1compartment NA NA Rat Human +DTXSID3041299 Css NA 0.03133 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041299 Css NA 0.1552 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041299 Css NA 0.02224 mg/L PBTK NA 50% Rat Human +DTXSID3041299 Css NA 0.1078 mg/L PBTK NA 95% Rat Human +DTXSID3041328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041328 Fup 0.0141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041328 Vd NA 2.522 L/kg 1compartment NA NA Human Human +DTXSID3041328 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3041328 TK.Half.Life NA 38.17 hours 1compartment NA NA Human Human +DTXSID3041328 Css NA 2.12 mg/L 3compartmentss NA 50% Human Human +DTXSID3041328 Css NA 15.27 mg/L 3compartmentss NA 95% Human Human +DTXSID3041328 Css NA 1.401 mg/L PBTK NA 50% Human Human +DTXSID3041328 Css NA 9.712 mg/L PBTK NA 95% Human Human +DTXSID3041328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041328 Fup 0.0141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041328 Vd NA 1.88 L/kg 1compartment NA NA Rat Human +DTXSID3041328 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3041328 TK.Half.Life NA 9.236 hours 1compartment NA NA Rat Human +DTXSID3041328 Css NA 0.275 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041328 Css NA 1.707 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041328 Css NA 0.1782 mg/L PBTK NA 50% Rat Human +DTXSID3041328 Css NA 1.058 mg/L PBTK NA 95% Rat Human +DTXSID3041370 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041370 Fup 0.779 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041370 Vd NA 0.6977 L/kg 1compartment NA NA Human Human DTXSID3041370 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041370 TK.Half.Life NA 5.299 hours 1compartment NA NA Human Human -DTXSID3041370 Css NA 0.8436 mg/L 3compartmentss NA 50% Human Human -DTXSID3041370 Css NA 2.896 mg/L 3compartmentss NA 95% Human Human -DTXSID3041370 Css NA 0.7099 mg/L PBTK NA 50% Human Human -DTXSID3041370 Css NA 2.041 mg/L PBTK NA 95% Human Human -DTXSID3041370 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041370 Fup NA 0.9663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041370 Vd NA 0.8234 L/kg 1compartment NA NA Rat Human +DTXSID3041370 TK.Half.Life NA 5.8 hours 1compartment NA NA Human Human +DTXSID3041370 Css NA 0.8673 mg/L 3compartmentss NA 50% Human Human +DTXSID3041370 Css NA 5.435 mg/L 3compartmentss NA 95% Human Human +DTXSID3041370 Css NA 0.707 mg/L PBTK NA 50% Human Human +DTXSID3041370 Css NA 3.494 mg/L PBTK NA 95% Human Human +DTXSID3041370 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041370 Fup 0.779 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041370 Vd NA 0.7255 L/kg 1compartment NA NA Rat Human DTXSID3041370 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041370 TK.Half.Life NA 1.879 hours 1compartment NA NA Rat Human -DTXSID3041370 Css NA 0.215 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041370 Css NA 0.6728 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041370 Css NA 0.1775 mg/L PBTK NA 50% Rat Human -DTXSID3041370 Css NA 0.4408 mg/L PBTK NA 95% Rat Human -DTXSID3041372 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041372 Fup NA 0.04 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041372 Vd NA 0.2549 L/kg 1compartment NA NA Human Human -DTXSID3041372 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID3041372 TK.Half.Life NA 41.23 hours 1compartment NA NA Human Human -DTXSID3041372 Css NA 27.78 mg/L 3compartmentss NA 50% Human Human -DTXSID3041372 Css NA 162.2 mg/L 3compartmentss NA 95% Human Human -DTXSID3041372 Css NA 16.77 mg/L PBTK NA 50% Human Human -DTXSID3041372 Css NA 95.39 mg/L PBTK NA 95% Human Human -DTXSID3041372 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041372 Fup NA 0.04 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041372 Vd NA 0.2513 L/kg 1compartment NA NA Rat Human -DTXSID3041372 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3041372 TK.Half.Life NA 13.85 hours 1compartment NA NA Rat Human -DTXSID3041372 Css NA 7.93 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041372 Css NA 39.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041372 Css NA 4.443 mg/L PBTK NA 50% Rat Human -DTXSID3041372 Css NA 21.46 mg/L PBTK NA 95% Rat Human +DTXSID3041370 TK.Half.Life NA 2.054 hours 1compartment NA NA Rat Human +DTXSID3041370 Css NA 0.01624 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041370 Css NA 0.1292 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041370 Css NA 0.01272 mg/L PBTK NA 50% Rat Human +DTXSID3041370 Css NA 0.08251 mg/L PBTK NA 95% Rat Human +DTXSID3041372 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041372 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041372 Vd NA 0.4031 L/kg 1compartment NA NA Human Human +DTXSID3041372 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3041372 TK.Half.Life NA 19.03 hours 1compartment NA NA Human Human +DTXSID3041372 Css NA 6.61 mg/L 3compartmentss NA 50% Human Human +DTXSID3041372 Css NA 31.48 mg/L 3compartmentss NA 95% Human Human +DTXSID3041372 Css NA 4.292 mg/L PBTK NA 50% Human Human +DTXSID3041372 Css NA 18.88 mg/L PBTK NA 95% Human Human +DTXSID3041372 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041372 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041372 Vd NA 0.4014 L/kg 1compartment NA NA Rat Human +DTXSID3041372 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3041372 TK.Half.Life NA 6.46 hours 1compartment NA NA Rat Human +DTXSID3041372 Css NA 0.4265 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041372 Css NA 1.698 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041372 Css NA 0.2703 mg/L PBTK NA 50% Rat Human +DTXSID3041372 Css NA 0.9847 mg/L PBTK NA 95% Rat Human DTXSID3041376 Clint 12.91 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID3041376 Fup 0.002679 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3041376 Vd NA 2.554 L/kg 1compartment NA NA Human Human -DTXSID3041376 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID3041376 TK.Half.Life NA 52.63 hours 1compartment NA NA Human Human -DTXSID3041376 Css NA 2.954 mg/L 3compartmentss NA 50% Human Human -DTXSID3041376 Css NA 20.3 mg/L 3compartmentss NA 95% Human Human -DTXSID3041376 Css NA 1.962 mg/L PBTK NA 50% Human Human -DTXSID3041376 Css NA 12.86 mg/L PBTK NA 95% Human Human +DTXSID3041376 Vd NA 0.9905 L/kg 1compartment NA NA Human Human +DTXSID3041376 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3041376 TK.Half.Life NA 41.93 hours 1compartment NA NA Human Human +DTXSID3041376 Css NA 4.224 mg/L 3compartmentss NA 50% Human Human +DTXSID3041376 Css NA 35.72 mg/L 3compartmentss NA 95% Human Human +DTXSID3041376 Css NA 2.525 mg/L PBTK NA 50% Human Human +DTXSID3041376 Css NA 20.99 mg/L PBTK NA 95% Human Human DTXSID3041376 Clint 12.91 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID3041376 Fup 0.002679 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3041376 Vd NA 1.914 L/kg 1compartment NA NA Rat Human -DTXSID3041376 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID3041376 TK.Half.Life NA 12.84 hours 1compartment NA NA Rat Human -DTXSID3041376 Css NA 1.673 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041376 Css NA 9.371 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041376 Css NA 1.049 mg/L PBTK NA 50% Rat Human -DTXSID3041376 Css NA 5.648 mg/L PBTK NA 95% Rat Human -DTXSID3041403 Clint NA 398.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041403 Fup NA 0.2226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041403 Vd NA 2.034 L/kg 1compartment NA NA Human Human +DTXSID3041376 Vd NA 0.7528 L/kg 1compartment NA NA Rat Human +DTXSID3041376 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3041376 TK.Half.Life NA 19.65 hours 1compartment NA NA Rat Human +DTXSID3041376 Css NA 0.04588 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041376 Css NA 0.3534 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041376 Css NA 0.02594 mg/L PBTK NA 50% Rat Human +DTXSID3041376 Css NA 0.1951 mg/L PBTK NA 95% Rat Human +DTXSID3041403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041403 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041403 Vd NA 1.798 L/kg 1compartment NA NA Human Human DTXSID3041403 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041403 TK.Half.Life NA 1.673 hours 1compartment NA NA Human Human -DTXSID3041403 Css NA 0.008202 mg/L 3compartmentss NA 50% Human Human -DTXSID3041403 Css NA 0.05583 mg/L 3compartmentss NA 95% Human Human -DTXSID3041403 Css NA 0.006001 mg/L PBTK NA 50% Human Human -DTXSID3041403 Css NA 0.03838 mg/L PBTK NA 95% Human Human -DTXSID3041403 Clint NA 398.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041403 Fup NA 0.2226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041403 Vd NA 1.574 L/kg 1compartment NA NA Rat Human +DTXSID3041403 TK.Half.Life NA 3.979 hours 1compartment NA NA Human Human +DTXSID3041403 Css NA 0.1896 mg/L 3compartmentss NA 50% Human Human +DTXSID3041403 Css NA 1.324 mg/L 3compartmentss NA 95% Human Human +DTXSID3041403 Css NA 0.1325 mg/L PBTK NA 50% Human Human +DTXSID3041403 Css NA 0.8804 mg/L PBTK NA 95% Human Human +DTXSID3041403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041403 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041403 Vd NA 1.386 L/kg 1compartment NA NA Rat Human DTXSID3041403 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041403 TK.Half.Life NA 0.5622 hours 1compartment NA NA Rat Human -DTXSID3041403 Css NA 0.004505 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041403 Css NA 0.02661 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041403 Css NA 0.003182 mg/L PBTK NA 50% Rat Human -DTXSID3041403 Css NA 0.01792 mg/L PBTK NA 95% Rat Human -DTXSID3041405 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041405 Fup NA 0.3383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041405 Vd NA 0.5301 L/kg 1compartment NA NA Human Human -DTXSID3041405 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3041405 TK.Half.Life NA 10.19 hours 1compartment NA NA Human Human -DTXSID3041405 Css NA 2.21 mg/L 3compartmentss NA 50% Human Human -DTXSID3041405 Css NA 8.964 mg/L 3compartmentss NA 95% Human Human -DTXSID3041405 Css NA 1.582 mg/L PBTK NA 50% Human Human -DTXSID3041405 Css NA 5.68 mg/L PBTK NA 95% Human Human -DTXSID3041405 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041405 Fup NA 0.3383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041405 Vd NA 0.5239 L/kg 1compartment NA NA Rat Human +DTXSID3041403 TK.Half.Life NA 1.433 hours 1compartment NA NA Rat Human +DTXSID3041403 Css NA 0.02376 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041403 Css NA 0.1328 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041403 Css NA 0.01647 mg/L PBTK NA 50% Rat Human +DTXSID3041403 Css NA 0.08657 mg/L PBTK NA 95% Rat Human +DTXSID3041405 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041405 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041405 Vd NA 0.445 L/kg 1compartment NA NA Human Human +DTXSID3041405 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3041405 TK.Half.Life NA 0.6966 hours 1compartment NA NA Human Human +DTXSID3041405 Css NA 0.09723 mg/L 3compartmentss NA 50% Human Human +DTXSID3041405 Css NA 0.7162 mg/L 3compartmentss NA 95% Human Human +DTXSID3041405 Css NA 0.0651 mg/L PBTK NA 50% Human Human +DTXSID3041405 Css NA 0.4508 mg/L PBTK NA 95% Human Human +DTXSID3041405 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041405 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041405 Vd NA 0.4347 L/kg 1compartment NA NA Rat Human DTXSID3041405 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041405 TK.Half.Life NA 3.42 hours 1compartment NA NA Rat Human -DTXSID3041405 Css NA 0.6149 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041405 Css NA 2.083 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041405 Css NA 0.4166 mg/L PBTK NA 50% Rat Human -DTXSID3041405 Css NA 1.223 mg/L PBTK NA 95% Rat Human +DTXSID3041405 TK.Half.Life NA 0.3715 hours 1compartment NA NA Rat Human +DTXSID3041405 Css NA 0.0124 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041405 Css NA 0.06876 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041405 Css NA 0.008151 mg/L PBTK NA 50% Rat Human +DTXSID3041405 Css NA 0.04329 mg/L PBTK NA 95% Rat Human DTXSID3041409 Clint 38.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3041409 Fup 0.401 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3041409 Vd NA 1.195 L/kg 1compartment NA NA Human Human DTXSID3041409 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3041409 TK.Half.Life NA 1.11 hours 1compartment NA NA Human Human -DTXSID3041409 Css NA 0.02892 mg/L 3compartmentss NA 50% Human Human -DTXSID3041409 Css NA 0.1809 mg/L 3compartmentss NA 95% Human Human -DTXSID3041409 Css NA 0.0228 mg/L PBTK NA 50% Human Human -DTXSID3041409 Css NA 0.1318 mg/L PBTK NA 95% Human Human +DTXSID3041409 Css NA 0.02605 mg/L 3compartmentss NA 50% Human Human +DTXSID3041409 Css NA 0.1805 mg/L 3compartmentss NA 95% Human Human +DTXSID3041409 Css NA 0.02062 mg/L PBTK NA 50% Human Human +DTXSID3041409 Css NA 0.1326 mg/L PBTK NA 95% Human Human DTXSID3041409 Clint 38.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3041409 Fup 0.401 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3041409 Vd NA 1.027 L/kg 1compartment NA NA Rat Human DTXSID3041409 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3041409 TK.Half.Life NA 0.4587 hours 1compartment NA NA Rat Human -DTXSID3041409 Css NA 0.01533 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041409 Css NA 0.07569 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041409 Css NA 0.01174 mg/L PBTK NA 50% Rat Human -DTXSID3041409 Css NA 0.0571 mg/L PBTK NA 95% Rat Human +DTXSID3041409 Css NA 0.00326 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041409 Css NA 0.01812 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041409 Css NA 0.002598 mg/L PBTK NA 50% Rat Human +DTXSID3041409 Css NA 0.01373 mg/L PBTK NA 95% Rat Human DTXSID3041451 Clint NA 0.1765 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3041451 Fup NA 0.5532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041451 Vd NA 0.5696 L/kg 1compartment NA NA Human Human +DTXSID3041451 Vd NA 0.4769 L/kg 1compartment NA NA Human Human DTXSID3041451 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041451 TK.Half.Life NA 5.008 hours 1compartment NA NA Human Human -DTXSID3041451 Css NA 0.975 mg/L 3compartmentss NA 50% Human Human -DTXSID3041451 Css NA 6.286 mg/L 3compartmentss NA 95% Human Human -DTXSID3041451 Css NA 0.7521 mg/L PBTK NA 50% Human Human -DTXSID3041451 Css NA 3.896 mg/L PBTK NA 95% Human Human +DTXSID3041451 TK.Half.Life NA 1.109 hours 1compartment NA NA Human Human +DTXSID3041451 Css NA 0.1886 mg/L 3compartmentss NA 50% Human Human +DTXSID3041451 Css NA 1.534 mg/L 3compartmentss NA 95% Human Human +DTXSID3041451 Css NA 0.1401 mg/L PBTK NA 50% Human Human +DTXSID3041451 Css NA 0.9683 mg/L PBTK NA 95% Human Human DTXSID3041451 Clint NA 0.1765 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3041451 Fup NA 0.5532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041451 Vd NA 0.5939 L/kg 1compartment NA NA Rat Human +DTXSID3041451 Vd NA 0.5146 L/kg 1compartment NA NA Rat Human DTXSID3041451 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041451 TK.Half.Life NA 2.038 hours 1compartment NA NA Rat Human -DTXSID3041451 Css NA 0.3039 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041451 Css NA 1.862 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041451 Css NA 0.2246 mg/L PBTK NA 50% Rat Human -DTXSID3041451 Css NA 1.086 mg/L PBTK NA 95% Rat Human -DTXSID3041530 Clint NA 23.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041530 Fup NA 0.0291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041530 Vd NA 0.7274 L/kg 1compartment NA NA Human Human +DTXSID3041451 TK.Half.Life NA 0.6472 hours 1compartment NA NA Rat Human +DTXSID3041451 Css NA 0.006127 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041451 Css NA 0.05758 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041451 Css NA 0.004382 mg/L PBTK NA 50% Rat Human +DTXSID3041451 Css NA 0.03615 mg/L PBTK NA 95% Rat Human +DTXSID3041530 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041530 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041530 Vd NA 1.058 L/kg 1compartment NA NA Human Human DTXSID3041530 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041530 TK.Half.Life NA 4.412 hours 1compartment NA NA Human Human -DTXSID3041530 Css NA 0.9568 mg/L 3compartmentss NA 50% Human Human -DTXSID3041530 Css NA 9.3 mg/L 3compartmentss NA 95% Human Human -DTXSID3041530 Css NA 0.5826 mg/L PBTK NA 50% Human Human -DTXSID3041530 Css NA 5.443 mg/L PBTK NA 95% Human Human -DTXSID3041530 Clint NA 23.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041530 Fup NA 0.0291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041530 Vd NA 0.5537 L/kg 1compartment NA NA Rat Human +DTXSID3041530 TK.Half.Life NA 2.35 hours 1compartment NA NA Human Human +DTXSID3041530 Css NA 0.2113 mg/L 3compartmentss NA 50% Human Human +DTXSID3041530 Css NA 1.757 mg/L 3compartmentss NA 95% Human Human +DTXSID3041530 Css NA 0.1414 mg/L PBTK NA 50% Human Human +DTXSID3041530 Css NA 1.126 mg/L PBTK NA 95% Human Human +DTXSID3041530 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041530 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041530 Vd NA 0.8764 L/kg 1compartment NA NA Rat Human DTXSID3041530 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041530 TK.Half.Life NA 2.051 hours 1compartment NA NA Rat Human -DTXSID3041530 Css NA 0.5464 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041530 Css NA 4.019 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041530 Css NA 0.31 mg/L PBTK NA 50% Rat Human -DTXSID3041530 Css NA 2.233 mg/L PBTK NA 95% Rat Human -DTXSID3041580 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041580 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041580 Vd NA 0.821 L/kg 1compartment NA NA Human Human +DTXSID3041530 TK.Half.Life NA 1.077 hours 1compartment NA NA Rat Human +DTXSID3041530 Css NA 0.02731 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041530 Css NA 0.1723 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041530 Css NA 0.01779 mg/L PBTK NA 50% Rat Human +DTXSID3041530 Css NA 0.1044 mg/L PBTK NA 95% Rat Human +DTXSID3041580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041580 Fup 0.699 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041580 Vd NA 0.6717 L/kg 1compartment NA NA Human Human DTXSID3041580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041580 TK.Half.Life NA 5.32 hours 1compartment NA NA Human Human -DTXSID3041580 Css NA 0.8159 mg/L 3compartmentss NA 50% Human Human -DTXSID3041580 Css NA 5.697 mg/L 3compartmentss NA 95% Human Human -DTXSID3041580 Css NA 0.695 mg/L PBTK NA 50% Human Human -DTXSID3041580 Css NA 3.713 mg/L PBTK NA 95% Human Human -DTXSID3041580 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041580 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041580 Vd NA 0.8532 L/kg 1compartment NA NA Rat Human +DTXSID3041580 TK.Half.Life NA 6.222 hours 1compartment NA NA Human Human +DTXSID3041580 Css NA 0.9346 mg/L 3compartmentss NA 50% Human Human +DTXSID3041580 Css NA 6.08 mg/L 3compartmentss NA 95% Human Human +DTXSID3041580 Css NA 0.7496 mg/L PBTK NA 50% Human Human +DTXSID3041580 Css NA 3.955 mg/L PBTK NA 95% Human Human +DTXSID3041580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041580 Fup 0.699 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041580 Vd NA 0.6953 L/kg 1compartment NA NA Rat Human DTXSID3041580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041580 TK.Half.Life NA 1.882 hours 1compartment NA NA Rat Human -DTXSID3041580 Css NA 0.205 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041580 Css NA 1.309 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041580 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID3041580 Css NA 0.7918 mg/L PBTK NA 95% Rat Human -DTXSID3041611 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041611 Fup NA 0.0232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041611 Vd NA 0.5208 L/kg 1compartment NA NA Human Human -DTXSID3041611 Days.Css NA 34 Days PBTK NA NA Human Human -DTXSID3041611 TK.Half.Life NA 150.7 hours 1compartment NA NA Human Human -DTXSID3041611 Css NA 48.38 mg/L 3compartmentss NA 50% Human Human -DTXSID3041611 Css NA 291.7 mg/L 3compartmentss NA 95% Human Human -DTXSID3041611 Css NA 29.52 mg/L PBTK NA 50% Human Human -DTXSID3041611 Css NA 168 mg/L PBTK NA 95% Human Human -DTXSID3041611 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041611 Fup NA 0.0232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041611 Vd NA 0.4182 L/kg 1compartment NA NA Rat Human -DTXSID3041611 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID3041611 TK.Half.Life NA 40.11 hours 1compartment NA NA Rat Human -DTXSID3041611 Css NA 13.62 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041611 Css NA 69.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041611 Css NA 7.751 mg/L PBTK NA 50% Rat Human -DTXSID3041611 Css NA 37.68 mg/L PBTK NA 95% Rat Human -DTXSID3041613 Clint NA 9.975 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041613 Fup NA 0.0833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041613 Vd NA 0.9385 L/kg 1compartment NA NA Human Human +DTXSID3041580 TK.Half.Life NA 2.194 hours 1compartment NA NA Rat Human +DTXSID3041580 Css NA 0.01775 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041580 Css NA 0.1452 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041580 Css NA 0.01378 mg/L PBTK NA 50% Rat Human +DTXSID3041580 Css NA 0.09183 mg/L PBTK NA 95% Rat Human +DTXSID3041582 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041582 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041582 Vd NA 3.107 L/kg 1compartment NA NA Human Human +DTXSID3041582 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID3041582 TK.Half.Life NA 87.58 hours 1compartment NA NA Human Human +DTXSID3041582 Css NA 3.366 mg/L 3compartmentss NA 50% Human Human +DTXSID3041582 Css NA 20.88 mg/L 3compartmentss NA 95% Human Human +DTXSID3041582 Css NA 2.351 mg/L PBTK NA 50% Human Human +DTXSID3041582 Css NA 14.29 mg/L PBTK NA 95% Human Human +DTXSID3041582 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041582 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041582 Vd NA 2.328 L/kg 1compartment NA NA Rat Human +DTXSID3041582 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID3041582 TK.Half.Life NA 12.01 hours 1compartment NA NA Rat Human +DTXSID3041582 Css NA 0.4359 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041582 Css NA 2.302 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041582 Css NA 0.2987 mg/L PBTK NA 50% Rat Human +DTXSID3041582 Css NA 1.529 mg/L PBTK NA 95% Rat Human +DTXSID3041611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041611 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041611 Vd NA 6.776 L/kg 1compartment NA NA Human Human +DTXSID3041611 Days.Css NA 39 Days PBTK NA NA Human Human +DTXSID3041611 TK.Half.Life NA 202.6 hours 1compartment NA NA Human Human +DTXSID3041611 Css NA 2.52 mg/L 3compartmentss NA 50% Human Human +DTXSID3041611 Css NA 15.61 mg/L 3compartmentss NA 95% Human Human +DTXSID3041611 Css NA 2.37 mg/L PBTK NA 50% Human Human +DTXSID3041611 Css NA 14.06 mg/L PBTK NA 95% Human Human +DTXSID3041611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041611 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041611 Vd NA 5.242 L/kg 1compartment NA NA Rat Human +DTXSID3041611 Days.Css NA 23 Days PBTK NA NA Rat Human +DTXSID3041611 TK.Half.Life NA 27.42 hours 1compartment NA NA Rat Human +DTXSID3041611 Css NA 0.3205 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041611 Css NA 1.555 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041611 Css NA 0.3056 mg/L PBTK NA 50% Rat Human +DTXSID3041611 Css NA 1.49 mg/L PBTK NA 95% Rat Human +DTXSID3041613 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041613 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041613 Vd NA 1.407 L/kg 1compartment NA NA Human Human DTXSID3041613 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041613 TK.Half.Life NA 4.98 hours 1compartment NA NA Human Human -DTXSID3041613 Css NA 0.7504 mg/L 3compartmentss NA 50% Human Human -DTXSID3041613 Css NA 5.369 mg/L 3compartmentss NA 95% Human Human -DTXSID3041613 Css NA 0.4802 mg/L PBTK NA 50% Human Human -DTXSID3041613 Css NA 3.29 mg/L PBTK NA 95% Human Human -DTXSID3041613 Clint NA 9.975 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041613 Fup NA 0.0833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041613 Vd NA 0.737 L/kg 1compartment NA NA Rat Human +DTXSID3041613 TK.Half.Life NA 5.975 hours 1compartment NA NA Human Human +DTXSID3041613 Css NA 0.436 mg/L 3compartmentss NA 50% Human Human +DTXSID3041613 Css NA 2.479 mg/L 3compartmentss NA 95% Human Human +DTXSID3041613 Css NA 0.3079 mg/L PBTK NA 50% Human Human +DTXSID3041613 Css NA 1.659 mg/L PBTK NA 95% Human Human +DTXSID3041613 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041613 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041613 Vd NA 1.112 L/kg 1compartment NA NA Rat Human DTXSID3041613 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041613 TK.Half.Life NA 2.256 hours 1compartment NA NA Rat Human -DTXSID3041613 Css NA 0.4133 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041613 Css NA 2.16 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041613 Css NA 0.247 mg/L PBTK NA 50% Rat Human -DTXSID3041613 Css NA 1.223 mg/L PBTK NA 95% Rat Human -DTXSID3041615 Clint NA 18.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041615 Fup NA 0.1408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041615 Vd NA 2.135 L/kg 1compartment NA NA Human Human +DTXSID3041613 TK.Half.Life NA 2.421 hours 1compartment NA NA Rat Human +DTXSID3041613 Css NA 0.05204 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041613 Css NA 0.2152 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041613 Css NA 0.03649 mg/L PBTK NA 50% Rat Human +DTXSID3041613 Css NA 0.1382 mg/L PBTK NA 95% Rat Human +DTXSID3041615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041615 Fup 0.0969 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041615 Vd NA 1.876 L/kg 1compartment NA NA Human Human DTXSID3041615 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041615 TK.Half.Life NA 6.639 hours 1compartment NA NA Human Human -DTXSID3041615 Css NA 0.3257 mg/L 3compartmentss NA 50% Human Human -DTXSID3041615 Css NA 2.251 mg/L 3compartmentss NA 95% Human Human -DTXSID3041615 Css NA 0.2272 mg/L PBTK NA 50% Human Human -DTXSID3041615 Css NA 1.486 mg/L PBTK NA 95% Human Human -DTXSID3041615 Clint NA 18.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041615 Fup NA 0.1408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041615 Vd NA 1.625 L/kg 1compartment NA NA Rat Human +DTXSID3041615 TK.Half.Life NA 6.064 hours 1compartment NA NA Human Human +DTXSID3041615 Css NA 0.3569 mg/L 3compartmentss NA 50% Human Human +DTXSID3041615 Css NA 2.611 mg/L 3compartmentss NA 95% Human Human +DTXSID3041615 Css NA 0.2392 mg/L PBTK NA 50% Human Human +DTXSID3041615 Css NA 1.664 mg/L PBTK NA 95% Human Human +DTXSID3041615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041615 Fup 0.0969 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041615 Vd NA 1.423 L/kg 1compartment NA NA Rat Human DTXSID3041615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041615 TK.Half.Life NA 2.113 hours 1compartment NA NA Rat Human -DTXSID3041615 Css NA 0.1798 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041615 Css NA 0.9554 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041615 Css NA 0.1192 mg/L PBTK NA 50% Rat Human -DTXSID3041615 Css NA 0.6148 mg/L PBTK NA 95% Rat Human -DTXSID3041617 Clint NA 41.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041617 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041617 Vd NA 1.217 L/kg 1compartment NA NA Human Human +DTXSID3041615 TK.Half.Life NA 2.102 hours 1compartment NA NA Rat Human +DTXSID3041615 Css NA 0.04602 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041615 Css NA 0.2646 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041615 Css NA 0.03031 mg/L PBTK NA 50% Rat Human +DTXSID3041615 Css NA 0.1675 mg/L PBTK NA 95% Rat Human +DTXSID3041617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041617 Fup 0.0821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041617 Vd NA 1.922 L/kg 1compartment NA NA Human Human DTXSID3041617 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041617 TK.Half.Life NA 4.255 hours 1compartment NA NA Human Human -DTXSID3041617 Css NA 0.4522 mg/L 3compartmentss NA 50% Human Human -DTXSID3041617 Css NA 3.554 mg/L 3compartmentss NA 95% Human Human -DTXSID3041617 Css NA 0.2832 mg/L PBTK NA 50% Human Human -DTXSID3041617 Css NA 2.144 mg/L PBTK NA 95% Human Human -DTXSID3041617 Clint NA 41.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041617 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041617 Vd NA 0.9132 L/kg 1compartment NA NA Rat Human +DTXSID3041617 TK.Half.Life NA 7.109 hours 1compartment NA NA Human Human +DTXSID3041617 Css NA 0.4276 mg/L 3compartmentss NA 50% Human Human +DTXSID3041617 Css NA 3.095 mg/L 3compartmentss NA 95% Human Human +DTXSID3041617 Css NA 0.2842 mg/L PBTK NA 50% Human Human +DTXSID3041617 Css NA 1.958 mg/L PBTK NA 95% Human Human +DTXSID3041617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041617 Fup 0.0821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041617 Vd NA 1.451 L/kg 1compartment NA NA Rat Human DTXSID3041617 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041617 TK.Half.Life NA 1.739 hours 1compartment NA NA Rat Human -DTXSID3041617 Css NA 0.2611 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041617 Css NA 1.568 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041617 Css NA 0.1526 mg/L PBTK NA 50% Rat Human -DTXSID3041617 Css NA 0.8974 mg/L PBTK NA 95% Rat Human -DTXSID3041619 Clint NA 11.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041619 Fup NA 0.032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041619 Vd NA 1.698 L/kg 1compartment NA NA Human Human -DTXSID3041619 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3041619 TK.Half.Life NA 20.8 hours 1compartment NA NA Human Human -DTXSID3041619 Css NA 1.923 mg/L 3compartmentss NA 50% Human Human -DTXSID3041619 Css NA 15.64 mg/L 3compartmentss NA 95% Human Human -DTXSID3041619 Css NA 1.23 mg/L PBTK NA 50% Human Human -DTXSID3041619 Css NA 9.47 mg/L PBTK NA 95% Human Human -DTXSID3041619 Clint NA 11.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041619 Fup NA 0.032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041619 Vd NA 1.267 L/kg 1compartment NA NA Rat Human -DTXSID3041619 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3041619 TK.Half.Life NA 7.468 hours 1compartment NA NA Rat Human -DTXSID3041619 Css NA 1.075 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041619 Css NA 6.368 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041619 Css NA 0.6443 mg/L PBTK NA 50% Rat Human -DTXSID3041619 Css NA 3.633 mg/L PBTK NA 95% Rat Human -DTXSID3041661 Clint NA 0.276 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041661 Fup NA 0.2459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041661 Vd NA 0.7528 L/kg 1compartment NA NA Human Human -DTXSID3041661 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3041661 TK.Half.Life NA 14.16 hours 1compartment NA NA Human Human -DTXSID3041661 Css NA 2.128 mg/L 3compartmentss NA 50% Human Human -DTXSID3041661 Css NA 8.369 mg/L 3compartmentss NA 95% Human Human -DTXSID3041661 Css NA 1.498 mg/L PBTK NA 50% Human Human -DTXSID3041661 Css NA 5.251 mg/L PBTK NA 95% Human Human -DTXSID3041661 Clint NA 0.276 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041661 Fup NA 0.2459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041661 Vd NA 0.654 L/kg 1compartment NA NA Rat Human +DTXSID3041617 TK.Half.Life NA 2.413 hours 1compartment NA NA Rat Human +DTXSID3041617 Css NA 0.05542 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041617 Css NA 0.3106 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041617 Css NA 0.03637 mg/L PBTK NA 50% Rat Human +DTXSID3041617 Css NA 0.1927 mg/L PBTK NA 95% Rat Human +DTXSID3041619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041619 Fup 0.0431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041619 Vd NA 1.899 L/kg 1compartment NA NA Human Human +DTXSID3041619 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3041619 TK.Half.Life NA 11.06 hours 1compartment NA NA Human Human +DTXSID3041619 Css NA 0.7824 mg/L 3compartmentss NA 50% Human Human +DTXSID3041619 Css NA 5.389 mg/L 3compartmentss NA 95% Human Human +DTXSID3041619 Css NA 0.5066 mg/L PBTK NA 50% Human Human +DTXSID3041619 Css NA 3.418 mg/L PBTK NA 95% Human Human +DTXSID3041619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041619 Fup 0.0431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041619 Vd NA 1.421 L/kg 1compartment NA NA Rat Human +DTXSID3041619 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3041619 TK.Half.Life NA 3.741 hours 1compartment NA NA Rat Human +DTXSID3041619 Css NA 0.1007 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041619 Css NA 0.5777 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041619 Css NA 0.06396 mg/L PBTK NA 50% Rat Human +DTXSID3041619 Css NA 0.355 mg/L PBTK NA 95% Rat Human +DTXSID3041661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041661 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041661 Vd NA 0.8751 L/kg 1compartment NA NA Human Human +DTXSID3041661 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3041661 TK.Half.Life NA 1.106 hours 1compartment NA NA Human Human +DTXSID3041661 Css NA 0.06419 mg/L 3compartmentss NA 50% Human Human +DTXSID3041661 Css NA 0.475 mg/L 3compartmentss NA 95% Human Human +DTXSID3041661 Css NA 0.04676 mg/L PBTK NA 50% Human Human +DTXSID3041661 Css NA 0.3188 mg/L PBTK NA 95% Human Human +DTXSID3041661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041661 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041661 Vd NA 0.7618 L/kg 1compartment NA NA Rat Human DTXSID3041661 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041661 TK.Half.Life NA 4.834 hours 1compartment NA NA Rat Human -DTXSID3041661 Css NA 0.7208 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041661 Css NA 2.401 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041661 Css NA 0.4808 mg/L PBTK NA 50% Rat Human -DTXSID3041661 Css NA 1.405 mg/L PBTK NA 95% Rat Human -DTXSID3041663 Clint NA 14.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041663 Fup NA 0.0311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041663 Vd NA 2.003 L/kg 1compartment NA NA Human Human -DTXSID3041663 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3041663 TK.Half.Life NA 21.38 hours 1compartment NA NA Human Human -DTXSID3041663 Css NA 1.635 mg/L 3compartmentss NA 50% Human Human -DTXSID3041663 Css NA 12.73 mg/L 3compartmentss NA 95% Human Human -DTXSID3041663 Css NA 1.059 mg/L PBTK NA 50% Human Human -DTXSID3041663 Css NA 7.79 mg/L PBTK NA 95% Human Human -DTXSID3041663 Clint NA 14.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041663 Fup NA 0.0311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041663 Vd NA 1.494 L/kg 1compartment NA NA Rat Human -DTXSID3041663 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3041663 TK.Half.Life NA 6.856 hours 1compartment NA NA Rat Human -DTXSID3041663 Css NA 0.8854 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041663 Css NA 5.388 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041663 Css NA 0.5427 mg/L PBTK NA 50% Rat Human -DTXSID3041663 Css NA 3.076 mg/L PBTK NA 95% Rat Human -DTXSID3041665 Clint NA 155.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041665 Fup NA 0.2355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041665 Vd NA 3.229 L/kg 1compartment NA NA Human Human -DTXSID3041665 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3041665 TK.Half.Life NA 4.273 hours 1compartment NA NA Human Human -DTXSID3041665 Css NA 0.06443 mg/L 3compartmentss NA 50% Human Human -DTXSID3041665 Css NA 0.4072 mg/L 3compartmentss NA 95% Human Human -DTXSID3041665 Css NA 0.04605 mg/L PBTK NA 50% Human Human -DTXSID3041665 Css NA 0.2851 mg/L PBTK NA 95% Human Human -DTXSID3041665 Clint NA 155.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041665 Fup NA 0.2355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041665 Vd NA 2.455 L/kg 1compartment NA NA Rat Human -DTXSID3041665 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041665 TK.Half.Life NA 1.078 hours 1compartment NA NA Rat Human -DTXSID3041665 Css NA 0.03556 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041665 Css NA 0.191 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041665 Css NA 0.02431 mg/L PBTK NA 50% Rat Human -DTXSID3041665 Css NA 0.1258 mg/L PBTK NA 95% Rat Human +DTXSID3041661 TK.Half.Life NA 0.4983 hours 1compartment NA NA Rat Human +DTXSID3041661 Css NA 0.007934 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041661 Css NA 0.04582 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041661 Css NA 0.005791 mg/L PBTK NA 50% Rat Human +DTXSID3041661 Css NA 0.03063 mg/L PBTK NA 95% Rat Human +DTXSID3041663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041663 Fup 0.0103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041663 Vd NA 2.095 L/kg 1compartment NA NA Human Human +DTXSID3041663 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3041663 TK.Half.Life NA 32.79 hours 1compartment NA NA Human Human +DTXSID3041663 Css NA 2.352 mg/L 3compartmentss NA 50% Human Human +DTXSID3041663 Css NA 19.72 mg/L 3compartmentss NA 95% Human Human +DTXSID3041663 Css NA 1.514 mg/L PBTK NA 50% Human Human +DTXSID3041663 Css NA 12.05 mg/L PBTK NA 95% Human Human +DTXSID3041663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041663 Fup 0.0103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041663 Vd NA 1.554 L/kg 1compartment NA NA Rat Human +DTXSID3041663 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3041663 TK.Half.Life NA 10.06 hours 1compartment NA NA Rat Human +DTXSID3041663 Css NA 0.3077 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041663 Css NA 2.112 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041663 Css NA 0.1925 mg/L PBTK NA 50% Rat Human +DTXSID3041663 Css NA 1.287 mg/L PBTK NA 95% Rat Human DTXSID3041744 Clint 13.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3041744 Fup 0.0456 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3041744 Vd NA 3.575 L/kg 1compartment NA NA Human Human -DTXSID3041744 Days.Css NA 31 Days PBTK NA NA Human Human -DTXSID3041744 TK.Half.Life NA 166 hours 1compartment NA NA Human Human -DTXSID3041744 Css NA 5.231 mg/L 3compartmentss NA 50% Human Human -DTXSID3041744 Css NA 29.75 mg/L 3compartmentss NA 95% Human Human -DTXSID3041744 Css NA 3.784 mg/L PBTK NA 50% Human Human -DTXSID3041744 Css NA 21.21 mg/L PBTK NA 95% Human Human +DTXSID3041744 Vd NA 2.832 L/kg 1compartment NA NA Human Human +DTXSID3041744 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID3041744 TK.Half.Life NA 45.27 hours 1compartment NA NA Human Human +DTXSID3041744 Css NA 1.854 mg/L 3compartmentss NA 50% Human Human +DTXSID3041744 Css NA 11.9 mg/L 3compartmentss NA 95% Human Human +DTXSID3041744 Css NA 1.282 mg/L PBTK NA 50% Human Human +DTXSID3041744 Css NA 7.925 mg/L PBTK NA 95% Human Human DTXSID3041744 Clint 13.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3041744 Fup 0.0456 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3041744 Vd NA 2.693 L/kg 1compartment NA NA Rat Human -DTXSID3041744 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID3041744 TK.Half.Life NA 21.66 hours 1compartment NA NA Rat Human -DTXSID3041744 Css NA 2.948 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041744 Css NA 12.84 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041744 Css NA 2.04 mg/L PBTK NA 50% Rat Human -DTXSID3041744 Css NA 8.973 mg/L PBTK NA 95% Rat Human -DTXSID3041794 Clint NA 23.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3041744 Vd NA 2.123 L/kg 1compartment NA NA Rat Human +DTXSID3041744 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3041744 TK.Half.Life NA 8.626 hours 1compartment NA NA Rat Human +DTXSID3041744 Css NA 0.2408 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041744 Css NA 1.236 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041744 Css NA 0.1643 mg/L PBTK NA 50% Rat Human +DTXSID3041744 Css NA 0.8155 mg/L PBTK NA 95% Rat Human +DTXSID3041794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3041794 Fup 0.0028 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3041794 Vd NA 2.453 L/kg 1compartment NA NA Human Human DTXSID3041794 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID3041794 TK.Half.Life NA 65.83 hours 1compartment NA NA Human Human -DTXSID3041794 Css NA 3.993 mg/L 3compartmentss NA 50% Human Human -DTXSID3041794 Css NA 29.49 mg/L 3compartmentss NA 95% Human Human -DTXSID3041794 Css NA 2.616 mg/L PBTK NA 50% Human Human -DTXSID3041794 Css NA 18.1 mg/L PBTK NA 95% Human Human -DTXSID3041794 Clint NA 23.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3041794 TK.Half.Life NA 69.82 hours 1compartment NA NA Human Human +DTXSID3041794 Css NA 4.081 mg/L 3compartmentss NA 50% Human Human +DTXSID3041794 Css NA 30.37 mg/L 3compartmentss NA 95% Human Human +DTXSID3041794 Css NA 2.658 mg/L PBTK NA 50% Human Human +DTXSID3041794 Css NA 19.2 mg/L PBTK NA 95% Human Human +DTXSID3041794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3041794 Fup 0.0028 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3041794 Vd NA 1.822 L/kg 1compartment NA NA Rat Human -DTXSID3041794 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID3041794 TK.Half.Life NA 16.5 hours 1compartment NA NA Rat Human -DTXSID3041794 Css NA 2.234 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041794 Css NA 13.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041794 Css NA 1.386 mg/L PBTK NA 50% Rat Human -DTXSID3041794 Css NA 7.949 mg/L PBTK NA 95% Rat Human -DTXSID3041827 Clint NA 1.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041827 Fup NA 0.0719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041827 Vd NA 2.609 L/kg 1compartment NA NA Human Human -DTXSID3041827 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID3041827 TK.Half.Life NA 141.1 hours 1compartment NA NA Human Human -DTXSID3041827 Css NA 7.299 mg/L 3compartmentss NA 50% Human Human -DTXSID3041827 Css NA 32.17 mg/L 3compartmentss NA 95% Human Human -DTXSID3041827 Css NA 4.982 mg/L PBTK NA 50% Human Human -DTXSID3041827 Css NA 20.97 mg/L PBTK NA 95% Human Human -DTXSID3041827 Clint NA 1.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041827 Fup NA 0.0719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041827 Vd NA 1.961 L/kg 1compartment NA NA Rat Human -DTXSID3041827 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID3041827 TK.Half.Life NA 28.12 hours 1compartment NA NA Rat Human -DTXSID3041827 Css NA 3.522 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041827 Css NA 10.82 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041827 Css NA 2.296 mg/L PBTK NA 50% Rat Human -DTXSID3041827 Css NA 6.567 mg/L PBTK NA 95% Rat Human -DTXSID3041873 Clint NA 29.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041873 Fup NA 0.0745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3041873 Vd NA 2.772 L/kg 1compartment NA NA Human Human +DTXSID3041794 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID3041794 TK.Half.Life NA 17.48 hours 1compartment NA NA Rat Human +DTXSID3041794 Css NA 0.53 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041794 Css NA 3.466 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041794 Css NA 0.3409 mg/L PBTK NA 50% Rat Human +DTXSID3041794 Css NA 2.13 mg/L PBTK NA 95% Rat Human +DTXSID3041827 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041827 Fup 0.0595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041827 Vd NA 2.52 L/kg 1compartment NA NA Human Human +DTXSID3041827 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3041827 TK.Half.Life NA 16.22 hours 1compartment NA NA Human Human +DTXSID3041827 Css NA 0.788 mg/L 3compartmentss NA 50% Human Human +DTXSID3041827 Css NA 5.285 mg/L 3compartmentss NA 95% Human Human +DTXSID3041827 Css NA 0.5308 mg/L PBTK NA 50% Human Human +DTXSID3041827 Css NA 3.415 mg/L PBTK NA 95% Human Human +DTXSID3041827 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041827 Fup 0.0595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041827 Vd NA 1.89 L/kg 1compartment NA NA Rat Human +DTXSID3041827 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3041827 TK.Half.Life NA 4.087 hours 1compartment NA NA Rat Human +DTXSID3041827 Css NA 0.1015 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041827 Css NA 0.5381 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041827 Css NA 0.0676 mg/L PBTK NA 50% Rat Human +DTXSID3041827 Css NA 0.3521 mg/L PBTK NA 95% Rat Human +DTXSID3041873 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041873 Fup 0.0399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3041873 Vd NA 2.509 L/kg 1compartment NA NA Human Human DTXSID3041873 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3041873 TK.Half.Life NA 15.14 hours 1compartment NA NA Human Human -DTXSID3041873 Css NA 0.6366 mg/L 3compartmentss NA 50% Human Human -DTXSID3041873 Css NA 4.124 mg/L 3compartmentss NA 95% Human Human -DTXSID3041873 Css NA 0.4365 mg/L PBTK NA 50% Human Human -DTXSID3041873 Css NA 2.716 mg/L PBTK NA 95% Human Human -DTXSID3041873 Clint NA 29.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041873 Fup NA 0.0745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3041873 Vd NA 2.082 L/kg 1compartment NA NA Rat Human -DTXSID3041873 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3041873 TK.Half.Life NA 3.29 hours 1compartment NA NA Rat Human -DTXSID3041873 Css NA 0.356 mg/L 3compartmentss NA 50% Rat Human -DTXSID3041873 Css NA 1.811 mg/L 3compartmentss NA 95% Rat Human -DTXSID3041873 Css NA 0.2328 mg/L PBTK NA 50% Rat Human -DTXSID3041873 Css NA 1.148 mg/L PBTK NA 95% Rat Human -DTXSID3042007 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042007 Fup NA 0.0497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042007 Vd NA 2.873 L/kg 1compartment NA NA Human Human -DTXSID3042007 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID3042007 TK.Half.Life NA 2787 hours 1compartment NA NA Human Human -DTXSID3042007 Css NA 119 mg/L 3compartmentss NA 50% Human Human -DTXSID3042007 Css NA 354.9 mg/L 3compartmentss NA 95% Human Human -DTXSID3042007 Css NA 81.94 mg/L PBTK NA 50% Human Human -DTXSID3042007 Css NA 225.1 mg/L PBTK NA 95% Human Human -DTXSID3042007 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042007 Fup NA 0.0497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042007 Vd NA 2.154 L/kg 1compartment NA NA Rat Human -DTXSID3042007 Days.Css NA 187 Days PBTK NA NA Rat Human -DTXSID3042007 TK.Half.Life NA 242.4 hours 1compartment NA NA Rat Human -DTXSID3042007 Css NA 32.61 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042007 Css NA 76.65 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042007 Css NA 21.36 mg/L PBTK NA 50% Rat Human -DTXSID3042007 Css NA 45.53 mg/L PBTK NA 95% Rat Human -DTXSID3042051 Clint NA 3.515 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042051 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042051 Vd NA 4.227 L/kg 1compartment NA NA Human Human +DTXSID3041873 TK.Half.Life NA 20.75 hours 1compartment NA NA Human Human +DTXSID3041873 Css NA 1.086 mg/L 3compartmentss NA 50% Human Human +DTXSID3041873 Css NA 8.02 mg/L 3compartmentss NA 95% Human Human +DTXSID3041873 Css NA 0.7273 mg/L PBTK NA 50% Human Human +DTXSID3041873 Css NA 5.197 mg/L PBTK NA 95% Human Human +DTXSID3041873 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041873 Fup 0.0399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3041873 Vd NA 1.878 L/kg 1compartment NA NA Rat Human +DTXSID3041873 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3041873 TK.Half.Life NA 5.196 hours 1compartment NA NA Rat Human +DTXSID3041873 Css NA 0.1408 mg/L 3compartmentss NA 50% Rat Human +DTXSID3041873 Css NA 0.8288 mg/L 3compartmentss NA 95% Rat Human +DTXSID3041873 Css NA 0.0928 mg/L PBTK NA 50% Rat Human +DTXSID3041873 Css NA 0.5281 mg/L PBTK NA 95% Rat Human +DTXSID3042051 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042051 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042051 Vd NA 0.8806 L/kg 1compartment NA NA Human Human DTXSID3042051 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3042051 TK.Half.Life NA 4.948 hours 1compartment NA NA Human Human -DTXSID3042051 Css NA 0.0784 mg/L 3compartmentss NA 50% Human Human -DTXSID3042051 Css NA 0.8246 mg/L 3compartmentss NA 95% Human Human -DTXSID3042051 Css NA 0.1063 mg/L PBTK NA 50% Human Human -DTXSID3042051 Css NA 0.7415 mg/L PBTK NA 95% Human Human -DTXSID3042051 Clint NA 3.515 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042051 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042051 Vd NA 4.322 L/kg 1compartment NA NA Rat Human +DTXSID3042051 TK.Half.Life NA 1.306 hours 1compartment NA NA Human Human +DTXSID3042051 Css NA 0.1077 mg/L 3compartmentss NA 50% Human Human +DTXSID3042051 Css NA 0.9885 mg/L 3compartmentss NA 95% Human Human +DTXSID3042051 Css NA 0.0881 mg/L PBTK NA 50% Human Human +DTXSID3042051 Css NA 0.6684 mg/L PBTK NA 95% Human Human +DTXSID3042051 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042051 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042051 Vd NA 0.8468 L/kg 1compartment NA NA Rat Human DTXSID3042051 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042051 TK.Half.Life NA 2.792 hours 1compartment NA NA Rat Human -DTXSID3042051 Css NA 0.03365 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042051 Css NA 0.315 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042051 Css NA 0.04764 mg/L PBTK NA 50% Rat Human -DTXSID3042051 Css NA 0.2397 mg/L PBTK NA 95% Rat Human -DTXSID3042053 Clint NA 0.3297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042053 Fup NA 0.1014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042053 Vd NA 0.3062 L/kg 1compartment NA NA Human Human -DTXSID3042053 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3042053 TK.Half.Life NA 12.65 hours 1compartment NA NA Human Human -DTXSID3042053 Css NA 6.328 mg/L 3compartmentss NA 50% Human Human -DTXSID3042053 Css NA 29.63 mg/L 3compartmentss NA 95% Human Human -DTXSID3042053 Css NA 3.936 mg/L PBTK NA 50% Human Human -DTXSID3042053 Css NA 17.56 mg/L PBTK NA 95% Human Human -DTXSID3042053 Clint NA 0.3297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042053 Fup NA 0.1014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042053 Vd NA 0.3041 L/kg 1compartment NA NA Rat Human +DTXSID3042051 TK.Half.Life NA 0.6736 hours 1compartment NA NA Rat Human +DTXSID3042051 Css NA 0.01216 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042051 Css NA 0.09905 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042051 Css NA 0.01012 mg/L PBTK NA 50% Rat Human +DTXSID3042051 Css NA 0.06231 mg/L PBTK NA 95% Rat Human +DTXSID3042053 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042053 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042053 Vd NA 0.4619 L/kg 1compartment NA NA Human Human +DTXSID3042053 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3042053 TK.Half.Life NA 0.6704 hours 1compartment NA NA Human Human +DTXSID3042053 Css NA 0.08324 mg/L 3compartmentss NA 50% Human Human +DTXSID3042053 Css NA 0.6235 mg/L 3compartmentss NA 95% Human Human +DTXSID3042053 Css NA 0.05784 mg/L PBTK NA 50% Human Human +DTXSID3042053 Css NA 0.4104 mg/L PBTK NA 95% Human Human +DTXSID3042053 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042053 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042053 Vd NA 0.4622 L/kg 1compartment NA NA Rat Human DTXSID3042053 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042053 TK.Half.Life NA 5.227 hours 1compartment NA NA Rat Human -DTXSID3042053 Css NA 2.202 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042053 Css NA 9.092 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042053 Css NA 1.287 mg/L PBTK NA 50% Rat Human -DTXSID3042053 Css NA 5.02 mg/L PBTK NA 95% Rat Human -DTXSID3042130 Clint NA 13.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042130 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042130 Vd NA 3.111 L/kg 1compartment NA NA Human Human -DTXSID3042130 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID3042130 TK.Half.Life NA 131.3 hours 1compartment NA NA Human Human -DTXSID3042130 Css NA 5.217 mg/L 3compartmentss NA 50% Human Human -DTXSID3042130 Css NA 31.47 mg/L 3compartmentss NA 95% Human Human -DTXSID3042130 Css NA 3.625 mg/L PBTK NA 50% Human Human -DTXSID3042130 Css NA 20.89 mg/L PBTK NA 95% Human Human -DTXSID3042130 Clint NA 13.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042130 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042130 Vd NA 2.33 L/kg 1compartment NA NA Rat Human -DTXSID3042130 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID3042130 TK.Half.Life NA 17.64 hours 1compartment NA NA Rat Human -DTXSID3042130 Css NA 2.938 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042130 Css NA 13.95 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042130 Css NA 1.948 mg/L PBTK NA 50% Rat Human -DTXSID3042130 Css NA 8.788 mg/L PBTK NA 95% Rat Human -DTXSID3042180 Clint NA 32.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042180 Fup NA 0.0949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042180 Vd NA 1.775 L/kg 1compartment NA NA Human Human +DTXSID3042053 TK.Half.Life NA 0.3644 hours 1compartment NA NA Rat Human +DTXSID3042053 Css NA 0.01053 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042053 Css NA 0.06004 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042053 Css NA 0.007272 mg/L PBTK NA 50% Rat Human +DTXSID3042053 Css NA 0.03893 mg/L PBTK NA 95% Rat Human +DTXSID3042180 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042180 Fup 0.0775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042180 Vd NA 1.634 L/kg 1compartment NA NA Human Human DTXSID3042180 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3042180 TK.Half.Life NA 4.245 hours 1compartment NA NA Human Human -DTXSID3042180 Css NA 0.242 mg/L 3compartmentss NA 50% Human Human -DTXSID3042180 Css NA 1.774 mg/L 3compartmentss NA 95% Human Human -DTXSID3042180 Css NA 0.1616 mg/L PBTK NA 50% Human Human -DTXSID3042180 Css NA 1.134 mg/L PBTK NA 95% Human Human -DTXSID3042180 Clint NA 32.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042180 Fup NA 0.0949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042180 Vd NA 1.348 L/kg 1compartment NA NA Rat Human +DTXSID3042180 TK.Half.Life NA 5.757 hours 1compartment NA NA Human Human +DTXSID3042180 Css NA 0.4156 mg/L 3compartmentss NA 50% Human Human +DTXSID3042180 Css NA 2.947 mg/L 3compartmentss NA 95% Human Human +DTXSID3042180 Css NA 0.274 mg/L PBTK NA 50% Human Human +DTXSID3042180 Css NA 1.857 mg/L PBTK NA 95% Human Human +DTXSID3042180 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042180 Fup 0.0775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042180 Vd NA 1.238 L/kg 1compartment NA NA Rat Human DTXSID3042180 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042180 TK.Half.Life NA 1.514 hours 1compartment NA NA Rat Human -DTXSID3042180 Css NA 0.1358 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042180 Css NA 0.7779 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042180 Css NA 0.0862 mg/L PBTK NA 50% Rat Human -DTXSID3042180 Css NA 0.4633 mg/L PBTK NA 95% Rat Human -DTXSID3042188 Clint NA 23.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042188 Fup NA 0.3732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042188 Vd NA 1.294 L/kg 1compartment NA NA Human Human +DTXSID3042180 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human +DTXSID3042180 Css NA 0.05384 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042180 Css NA 0.3078 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042180 Css NA 0.03463 mg/L PBTK NA 50% Rat Human +DTXSID3042180 Css NA 0.1889 mg/L PBTK NA 95% Rat Human +DTXSID3042188 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042188 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042188 Vd NA 1.406 L/kg 1compartment NA NA Human Human DTXSID3042188 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3042188 TK.Half.Life NA 1.469 hours 1compartment NA NA Human Human -DTXSID3042188 Css NA 0.05431 mg/L 3compartmentss NA 50% Human Human -DTXSID3042188 Css NA 0.3909 mg/L 3compartmentss NA 95% Human Human -DTXSID3042188 Css NA 0.0424 mg/L PBTK NA 50% Human Human -DTXSID3042188 Css NA 0.2785 mg/L PBTK NA 95% Human Human -DTXSID3042188 Clint NA 23.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042188 Fup NA 0.3732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042188 Vd NA 1.091 L/kg 1compartment NA NA Rat Human +DTXSID3042188 TK.Half.Life NA 1.313 hours 1compartment NA NA Human Human +DTXSID3042188 Css NA 0.03641 mg/L 3compartmentss NA 50% Human Human +DTXSID3042188 Css NA 0.3804 mg/L 3compartmentss NA 95% Human Human +DTXSID3042188 Css NA 0.03057 mg/L PBTK NA 50% Human Human +DTXSID3042188 Css NA 0.27 mg/L PBTK NA 95% Human Human +DTXSID3042188 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042188 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042188 Vd NA 1.22 L/kg 1compartment NA NA Rat Human DTXSID3042188 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042188 TK.Half.Life NA 0.6145 hours 1compartment NA NA Rat Human -DTXSID3042188 Css NA 0.0288 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042188 Css NA 0.1712 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042188 Css NA 0.02176 mg/L PBTK NA 50% Rat Human -DTXSID3042188 Css NA 0.1155 mg/L PBTK NA 95% Rat Human -DTXSID3042261 Clint NA 16.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042261 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042261 Vd NA 2.925 L/kg 1compartment NA NA Human Human -DTXSID3042261 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID3042261 TK.Half.Life NA 72.57 hours 1compartment NA NA Human Human -DTXSID3042261 Css NA 3.258 mg/L 3compartmentss NA 50% Human Human -DTXSID3042261 Css NA 21.84 mg/L 3compartmentss NA 95% Human Human -DTXSID3042261 Css NA 2.227 mg/L PBTK NA 50% Human Human -DTXSID3042261 Css NA 14.58 mg/L PBTK NA 95% Human Human -DTXSID3042261 Clint NA 16.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042261 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042261 Vd NA 2.19 L/kg 1compartment NA NA Rat Human -DTXSID3042261 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID3042261 TK.Half.Life NA 12.39 hours 1compartment NA NA Rat Human -DTXSID3042261 Css NA 1.816 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042261 Css NA 9.463 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042261 Css NA 1.18 mg/L PBTK NA 50% Rat Human -DTXSID3042261 Css NA 5.949 mg/L PBTK NA 95% Rat Human -DTXSID3042269 Clint NA 78.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042269 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042269 Vd NA 3.04 L/kg 1compartment NA NA Human Human -DTXSID3042269 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3042269 TK.Half.Life NA 23.86 hours 1compartment NA NA Human Human -DTXSID3042269 Css NA 0.9024 mg/L 3compartmentss NA 50% Human Human -DTXSID3042269 Css NA 5.941 mg/L 3compartmentss NA 95% Human Human -DTXSID3042269 Css NA 0.6198 mg/L PBTK NA 50% Human Human -DTXSID3042269 Css NA 3.96 mg/L PBTK NA 95% Human Human -DTXSID3042269 Clint NA 78.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042269 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042269 Vd NA 2.275 L/kg 1compartment NA NA Rat Human -DTXSID3042269 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3042269 TK.Half.Life NA 3.903 hours 1compartment NA NA Rat Human -DTXSID3042269 Css NA 0.5154 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042269 Css NA 2.707 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042269 Css NA 0.3394 mg/L PBTK NA 50% Rat Human -DTXSID3042269 Css NA 1.701 mg/L PBTK NA 95% Rat Human +DTXSID3042188 TK.Half.Life NA 0.5514 hours 1compartment NA NA Rat Human +DTXSID3042188 Css NA 0.004328 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042188 Css NA 0.04042 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042188 Css NA 0.003754 mg/L PBTK NA 50% Rat Human +DTXSID3042188 Css NA 0.02786 mg/L PBTK NA 95% Rat Human +DTXSID3042261 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042261 Fup 0.0132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042261 Vd NA 2.851 L/kg 1compartment NA NA Human Human +DTXSID3042261 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID3042261 TK.Half.Life NA 55.01 hours 1compartment NA NA Human Human +DTXSID3042261 Css NA 2.513 mg/L 3compartmentss NA 50% Human Human +DTXSID3042261 Css NA 17.37 mg/L 3compartmentss NA 95% Human Human +DTXSID3042261 Css NA 1.703 mg/L PBTK NA 50% Human Human +DTXSID3042261 Css NA 11.34 mg/L PBTK NA 95% Human Human +DTXSID3042261 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042261 Fup 0.0132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042261 Vd NA 2.132 L/kg 1compartment NA NA Rat Human +DTXSID3042261 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID3042261 TK.Half.Life NA 10.21 hours 1compartment NA NA Rat Human +DTXSID3042261 Css NA 0.3258 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042261 Css NA 1.979 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042261 Css NA 0.2175 mg/L PBTK NA 50% Rat Human +DTXSID3042261 Css NA 1.275 mg/L PBTK NA 95% Rat Human +DTXSID3042269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042269 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042269 Vd NA 3.069 L/kg 1compartment NA NA Human Human +DTXSID3042269 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID3042269 TK.Half.Life NA 82.14 hours 1compartment NA NA Human Human +DTXSID3042269 Css NA 3.245 mg/L 3compartmentss NA 50% Human Human +DTXSID3042269 Css NA 21.56 mg/L 3compartmentss NA 95% Human Human +DTXSID3042269 Css NA 2.231 mg/L PBTK NA 50% Human Human +DTXSID3042269 Css NA 14.6 mg/L PBTK NA 95% Human Human +DTXSID3042269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042269 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042269 Vd NA 2.298 L/kg 1compartment NA NA Rat Human +DTXSID3042269 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID3042269 TK.Half.Life NA 11.85 hours 1compartment NA NA Rat Human +DTXSID3042269 Css NA 0.4198 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042269 Css NA 2.307 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042269 Css NA 0.2868 mg/L PBTK NA 50% Rat Human +DTXSID3042269 Css NA 1.505 mg/L PBTK NA 95% Rat Human +DTXSID3042344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042344 Fup 0.822 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042344 Vd NA 0.6885 L/kg 1compartment NA NA Human Human +DTXSID3042344 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3042344 TK.Half.Life NA 0.5523 hours 1compartment NA NA Human Human +DTXSID3042344 Css NA 0.02175 mg/L 3compartmentss NA 50% Human Human +DTXSID3042344 Css NA 0.2403 mg/L 3compartmentss NA 95% Human Human +DTXSID3042344 Css NA 0.0169 mg/L PBTK NA 50% Human Human +DTXSID3042344 Css NA 0.1666 mg/L PBTK NA 95% Human Human +DTXSID3042344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042344 Fup 0.822 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042344 Vd NA 0.6866 L/kg 1compartment NA NA Rat Human +DTXSID3042344 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3042344 TK.Half.Life NA 0.2641 hours 1compartment NA NA Rat Human +DTXSID3042344 Css NA 0.0007548 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042344 Css NA 0.0101 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042344 Css NA 0.0005842 mg/L PBTK NA 50% Rat Human +DTXSID3042344 Css NA 0.006625 mg/L PBTK NA 95% Rat Human DTXSID3042390 Clint NA 0.00171 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3042390 Fup NA 0.6278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042390 Vd NA 0.7261 L/kg 1compartment NA NA Human Human +DTXSID3042390 Vd NA 0.657 L/kg 1compartment NA NA Human Human DTXSID3042390 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3042390 TK.Half.Life NA 7.46 hours 1compartment NA NA Human Human -DTXSID3042390 Css NA 1.15 mg/L 3compartmentss NA 50% Human Human -DTXSID3042390 Css NA 8.108 mg/L 3compartmentss NA 95% Human Human -DTXSID3042390 Css NA 0.95 mg/L PBTK NA 50% Human Human -DTXSID3042390 Css NA 5.125 mg/L PBTK NA 95% Human Human +DTXSID3042390 TK.Half.Life NA 6.749 hours 1compartment NA NA Human Human +DTXSID3042390 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human +DTXSID3042390 Css NA 6.791 mg/L 3compartmentss NA 95% Human Human +DTXSID3042390 Css NA 0.8092 mg/L PBTK NA 50% Human Human +DTXSID3042390 Css NA 4.295 mg/L PBTK NA 95% Human Human DTXSID3042390 Clint NA 0.00171 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3042390 Fup NA 0.6278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042390 Vd NA 0.7437 L/kg 1compartment NA NA Rat Human +DTXSID3042390 Vd NA 0.6794 L/kg 1compartment NA NA Rat Human DTXSID3042390 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042390 TK.Half.Life NA 2.609 hours 1compartment NA NA Rat Human -DTXSID3042390 Css NA 0.3023 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042390 Css NA 2.021 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042390 Css NA 0.2405 mg/L PBTK NA 50% Rat Human -DTXSID3042390 Css NA 1.195 mg/L PBTK NA 95% Rat Human -DTXSID3042394 Clint NA 1.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042394 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042394 Vd NA 0.2553 L/kg 1compartment NA NA Human Human +DTXSID3042390 TK.Half.Life NA 2.382 hours 1compartment NA NA Rat Human +DTXSID3042390 Css NA 0.01914 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042390 Css NA 0.162 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042390 Css NA 0.01496 mg/L PBTK NA 50% Rat Human +DTXSID3042390 Css NA 0.1024 mg/L PBTK NA 95% Rat Human +DTXSID3042394 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042394 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042394 Vd NA 0.4437 L/kg 1compartment NA NA Human Human DTXSID3042394 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3042394 TK.Half.Life NA 6.918 hours 1compartment NA NA Human Human -DTXSID3042394 Css NA 4.456 mg/L 3compartmentss NA 50% Human Human -DTXSID3042394 Css NA 23.46 mg/L 3compartmentss NA 95% Human Human -DTXSID3042394 Css NA 2.699 mg/L PBTK NA 50% Human Human -DTXSID3042394 Css NA 13.7 mg/L PBTK NA 95% Human Human -DTXSID3042394 Clint NA 1.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042394 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042394 Vd NA 0.257 L/kg 1compartment NA NA Rat Human +DTXSID3042394 TK.Half.Life NA 7.863 hours 1compartment NA NA Human Human +DTXSID3042394 Css NA 2.006 mg/L 3compartmentss NA 50% Human Human +DTXSID3042394 Css NA 8.443 mg/L 3compartmentss NA 95% Human Human +DTXSID3042394 Css NA 1.423 mg/L PBTK NA 50% Human Human +DTXSID3042394 Css NA 5.305 mg/L PBTK NA 95% Human Human +DTXSID3042394 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042394 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042394 Vd NA 0.4627 L/kg 1compartment NA NA Rat Human DTXSID3042394 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042394 TK.Half.Life NA 3.66 hours 1compartment NA NA Rat Human -DTXSID3042394 Css NA 1.975 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042394 Css NA 8.089 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042394 Css NA 1.121 mg/L PBTK NA 50% Rat Human -DTXSID3042394 Css NA 4.429 mg/L PBTK NA 95% Rat Human +DTXSID3042394 TK.Half.Life NA 2.796 hours 1compartment NA NA Rat Human +DTXSID3042394 Css NA 0.1295 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042394 Css NA 0.4513 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042394 Css NA 0.09005 mg/L PBTK NA 50% Rat Human +DTXSID3042394 Css NA 0.2726 mg/L PBTK NA 95% Rat Human DTXSID3042423 Clint 194 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3042423 Fup NA 0.5111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042423 Vd NA 0.915 L/kg 1compartment NA NA Human Human +DTXSID3042423 Vd NA 0.9196 L/kg 1compartment NA NA Human Human DTXSID3042423 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3042423 TK.Half.Life NA 0.633 hours 1compartment NA NA Human Human -DTXSID3042423 Css NA 0.004546 mg/L 3compartmentss NA 50% Human Human -DTXSID3042423 Css NA 0.04293 mg/L 3compartmentss NA 95% Human Human -DTXSID3042423 Css NA 0.003639 mg/L PBTK NA 50% Human Human -DTXSID3042423 Css NA 0.03002 mg/L PBTK NA 95% Human Human +DTXSID3042423 TK.Half.Life NA 0.6353 hours 1compartment NA NA Human Human +DTXSID3042423 Css NA 0.001768 mg/L 3compartmentss NA 50% Human Human +DTXSID3042423 Css NA 0.03433 mg/L 3compartmentss NA 95% Human Human +DTXSID3042423 Css NA 0.001423 mg/L PBTK NA 50% Human Human +DTXSID3042423 Css NA 0.02335 mg/L PBTK NA 95% Human Human DTXSID3042423 Clint 194 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3042423 Fup NA 0.5111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042423 Vd NA 0.8534 L/kg 1compartment NA NA Rat Human +DTXSID3042423 Vd NA 0.8571 L/kg 1compartment NA NA Rat Human DTXSID3042423 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042423 TK.Half.Life NA 0.262 hours 1compartment NA NA Rat Human -DTXSID3042423 Css NA 0.002466 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042423 Css NA 0.01981 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042423 Css NA 0.001919 mg/L PBTK NA 50% Rat Human -DTXSID3042423 Css NA 0.01352 mg/L PBTK NA 95% Rat Human -DTXSID3042477 Clint NA 127.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042477 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042477 Vd NA 0.9577 L/kg 1compartment NA NA Human Human +DTXSID3042423 TK.Half.Life NA 0.263 hours 1compartment NA NA Rat Human +DTXSID3042423 Css NA 5.924e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042423 Css NA 0.001279 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042423 Css NA 4.711e-05 mg/L PBTK NA 50% Rat Human +DTXSID3042423 Css NA 0.0008735 mg/L PBTK NA 95% Rat Human +DTXSID3042477 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042477 Fup 0.0365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042477 Vd NA 0.8511 L/kg 1compartment NA NA Human Human DTXSID3042477 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3042477 TK.Half.Life NA 2.285 hours 1compartment NA NA Human Human -DTXSID3042477 Css NA 0.2688 mg/L 3compartmentss NA 50% Human Human -DTXSID3042477 Css NA 2.766 mg/L 3compartmentss NA 95% Human Human -DTXSID3042477 Css NA 0.1647 mg/L PBTK NA 50% Human Human -DTXSID3042477 Css NA 1.622 mg/L PBTK NA 95% Human Human -DTXSID3042477 Clint NA 127.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042477 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042477 Vd NA 0.7132 L/kg 1compartment NA NA Rat Human +DTXSID3042477 TK.Half.Life NA 4.665 hours 1compartment NA NA Human Human +DTXSID3042477 Css NA 0.8484 mg/L 3compartmentss NA 50% Human Human +DTXSID3042477 Css NA 7.085 mg/L 3compartmentss NA 95% Human Human +DTXSID3042477 Css NA 0.5214 mg/L PBTK NA 50% Human Human +DTXSID3042477 Css NA 4.211 mg/L PBTK NA 95% Human Human +DTXSID3042477 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042477 Fup 0.0365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042477 Vd NA 0.6468 L/kg 1compartment NA NA Rat Human DTXSID3042477 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042477 TK.Half.Life NA 0.9373 hours 1compartment NA NA Rat Human -DTXSID3042477 Css NA 0.1531 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042477 Css NA 1.329 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042477 Css NA 0.08735 mg/L PBTK NA 50% Rat Human -DTXSID3042477 Css NA 0.7455 mg/L PBTK NA 95% Rat Human -DTXSID3042500 Clint NA 49.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042500 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042500 Vd NA 10.2 L/kg 1compartment NA NA Human Human -DTXSID3042500 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID3042500 TK.Half.Life NA 137.4 hours 1compartment NA NA Human Human -DTXSID3042500 Css NA 0.8912 mg/L 3compartmentss NA 50% Human Human -DTXSID3042500 Css NA 5.079 mg/L 3compartmentss NA 95% Human Human -DTXSID3042500 Css NA 1.082 mg/L PBTK NA 50% Human Human -DTXSID3042500 Css NA 5.877 mg/L PBTK NA 95% Human Human -DTXSID3042500 Clint NA 49.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042500 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042500 Vd NA 8.034 L/kg 1compartment NA NA Rat Human -DTXSID3042500 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID3042500 TK.Half.Life NA 19.59 hours 1compartment NA NA Rat Human -DTXSID3042500 Css NA 0.4857 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042500 Css NA 2.071 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042500 Css NA 0.5845 mg/L PBTK NA 50% Rat Human -DTXSID3042500 Css NA 2.441 mg/L PBTK NA 95% Rat Human +DTXSID3042477 TK.Half.Life NA 2.108 hours 1compartment NA NA Rat Human +DTXSID3042477 Css NA 0.11 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042477 Css NA 0.728 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042477 Css NA 0.06575 mg/L PBTK NA 50% Rat Human +DTXSID3042477 Css NA 0.418 mg/L PBTK NA 95% Rat Human DTXSID3042508 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3042508 Fup NA 0.4511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3042508 Vd NA 0.3234 L/kg 1compartment NA NA Human Human +DTXSID3042508 Vd NA 0.3221 L/kg 1compartment NA NA Human Human DTXSID3042508 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3042508 TK.Half.Life NA 4.64 hours 1compartment NA NA Human Human -DTXSID3042508 Css NA 1.768 mg/L 3compartmentss NA 50% Human Human -DTXSID3042508 Css NA 7.718 mg/L 3compartmentss NA 95% Human Human -DTXSID3042508 Css NA 1.197 mg/L PBTK NA 50% Human Human -DTXSID3042508 Css NA 4.73 mg/L PBTK NA 95% Human Human +DTXSID3042508 TK.Half.Life NA 4.621 hours 1compartment NA NA Human Human +DTXSID3042508 Css NA 0.9413 mg/L 3compartmentss NA 50% Human Human +DTXSID3042508 Css NA 4.681 mg/L 3compartmentss NA 95% Human Human +DTXSID3042508 Css NA 0.6388 mg/L PBTK NA 50% Human Human +DTXSID3042508 Css NA 2.851 mg/L PBTK NA 95% Human Human DTXSID3042508 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3042508 Fup NA 0.4511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3042508 Vd NA 0.3406 L/kg 1compartment NA NA Rat Human +DTXSID3042508 Vd NA 0.3384 L/kg 1compartment NA NA Rat Human DTXSID3042508 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042508 TK.Half.Life NA 1.665 hours 1compartment NA NA Rat Human -DTXSID3042508 Css NA 0.4863 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042508 Css NA 1.843 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042508 Css NA 0.3109 mg/L PBTK NA 50% Rat Human -DTXSID3042508 Css NA 1.049 mg/L PBTK NA 95% Rat Human +DTXSID3042508 TK.Half.Life NA 1.654 hours 1compartment NA NA Rat Human +DTXSID3042508 Css NA 0.005199 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042508 Css NA 0.02441 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042508 Css NA 0.003348 mg/L PBTK NA 50% Rat Human +DTXSID3042508 Css NA 0.01416 mg/L PBTK NA 95% Rat Human +DTXSID3042631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042631 Fup 0.046 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042631 Vd NA 2.502 L/kg 1compartment NA NA Human Human +DTXSID3042631 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3042631 TK.Half.Life NA 9.314 hours 1compartment NA NA Human Human +DTXSID3042631 Css NA 0.4122 mg/L 3compartmentss NA 50% Human Human +DTXSID3042631 Css NA 3.276 mg/L 3compartmentss NA 95% Human Human +DTXSID3042631 Css NA 0.3006 mg/L PBTK NA 50% Human Human +DTXSID3042631 Css NA 2.213 mg/L PBTK NA 95% Human Human +DTXSID3042631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042631 Fup 0.046 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042631 Vd NA 2.079 L/kg 1compartment NA NA Rat Human +DTXSID3042631 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3042631 TK.Half.Life NA 3.511 hours 1compartment NA NA Rat Human +DTXSID3042631 Css NA 0.05358 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042631 Css NA 0.3304 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042631 Css NA 0.03831 mg/L PBTK NA 50% Rat Human +DTXSID3042631 Css NA 0.2234 mg/L PBTK NA 95% Rat Human DTXSID3042633 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3042633 Fup 0.041 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3042633 Vd NA 3.108 L/kg 1compartment NA NA Human Human -DTXSID3042633 Days.Css NA 3193 Days PBTK NA NA Human Human -DTXSID3042633 TK.Half.Life NA 11610 hours 1compartment NA NA Human Human -DTXSID3042633 Css NA 423.4 mg/L 3compartmentss NA 50% Human Human -DTXSID3042633 Css NA 1177 mg/L 3compartmentss NA 95% Human Human -DTXSID3042633 Css NA 297.8 mg/L PBTK NA 50% Human Human -DTXSID3042633 Css NA 772.2 mg/L PBTK NA 95% Human Human +DTXSID3042633 Vd NA 1.061 L/kg 1compartment NA NA Human Human +DTXSID3042633 Days.Css NA 40 Days PBTK NA NA Human Human +DTXSID3042633 TK.Half.Life NA 182.2 hours 1compartment NA NA Human Human +DTXSID3042633 Css NA 20.3 mg/L 3compartmentss NA 50% Human Human +DTXSID3042633 Css NA 92.61 mg/L 3compartmentss NA 95% Human Human +DTXSID3042633 Css NA 13.3 mg/L PBTK NA 50% Human Human +DTXSID3042633 Css NA 55.27 mg/L PBTK NA 95% Human Human DTXSID3042633 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3042633 Fup 0.041 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3042633 Vd NA 2.347 L/kg 1compartment NA NA Rat Human -DTXSID3042633 Days.Css NA 820 Days PBTK NA NA Rat Human -DTXSID3042633 TK.Half.Life NA 808.1 hours 1compartment NA NA Rat Human -DTXSID3042633 Css NA 114.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042633 Css NA 255.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042633 Css NA 77.24 mg/L PBTK NA 50% Rat Human -DTXSID3042633 Css NA 155 mg/L PBTK NA 95% Rat Human -DTXSID3042681 Clint NA 7.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3042633 Vd NA 0.9112 L/kg 1compartment NA NA Rat Human +DTXSID3042633 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID3042633 TK.Half.Life NA 50.01 hours 1compartment NA NA Rat Human +DTXSID3042633 Css NA 1.309 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042633 Css NA 4.811 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042633 Css NA 0.8342 mg/L PBTK NA 50% Rat Human +DTXSID3042633 Css NA 2.804 mg/L PBTK NA 95% Rat Human +DTXSID3042681 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3042681 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3042681 Vd NA 0.5647 L/kg 1compartment NA NA Human Human -DTXSID3042681 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3042681 TK.Half.Life NA 1.516 hours 1compartment NA NA Human Human -DTXSID3042681 Css NA 0.2406 mg/L 3compartmentss NA 50% Human Human -DTXSID3042681 Css NA 1.411 mg/L 3compartmentss NA 95% Human Human -DTXSID3042681 Css NA 0.1776 mg/L PBTK NA 50% Human Human -DTXSID3042681 Css NA 0.9506 mg/L PBTK NA 95% Human Human -DTXSID3042681 Clint NA 7.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3042681 Vd NA 1.241 L/kg 1compartment NA NA Human Human +DTXSID3042681 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID3042681 TK.Half.Life NA 38.09 hours 1compartment NA NA Human Human +DTXSID3042681 Css NA 3.212 mg/L 3compartmentss NA 50% Human Human +DTXSID3042681 Css NA 11.62 mg/L 3compartmentss NA 95% Human Human +DTXSID3042681 Css NA 2.355 mg/L PBTK NA 50% Human Human +DTXSID3042681 Css NA 7.542 mg/L PBTK NA 95% Human Human +DTXSID3042681 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3042681 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3042681 Vd NA 0.5597 L/kg 1compartment NA NA Rat Human -DTXSID3042681 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3042681 TK.Half.Life NA 0.8753 hours 1compartment NA NA Rat Human -DTXSID3042681 Css NA 0.1237 mg/L 3compartmentss NA 50% Rat Human -DTXSID3042681 Css NA 0.5624 mg/L 3compartmentss NA 95% Rat Human -DTXSID3042681 Css NA 0.08769 mg/L PBTK NA 50% Rat Human -DTXSID3042681 Css NA 0.3554 mg/L PBTK NA 95% Rat Human -DTXSID3043734 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3042681 Vd NA 1.011 L/kg 1compartment NA NA Rat Human +DTXSID3042681 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3042681 TK.Half.Life NA 9.311 hours 1compartment NA NA Rat Human +DTXSID3042681 Css NA 0.139 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042681 Css NA 0.5003 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042681 Css NA 0.1039 mg/L PBTK NA 50% Rat Human +DTXSID3042681 Css NA 0.3143 mg/L PBTK NA 95% Rat Human +DTXSID3042685 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3042685 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3042685 Vd NA 2.698 L/kg 1compartment NA NA Human Human +DTXSID3042685 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3042685 TK.Half.Life NA 3.84 hours 1compartment NA NA Human Human +DTXSID3042685 Css NA 0.08845 mg/L 3compartmentss NA 50% Human Human +DTXSID3042685 Css NA 0.8816 mg/L 3compartmentss NA 95% Human Human +DTXSID3042685 Css NA 0.09221 mg/L PBTK NA 50% Human Human +DTXSID3042685 Css NA 0.6662 mg/L PBTK NA 95% Human Human +DTXSID3042685 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3042685 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3042685 Vd NA 2.566 L/kg 1compartment NA NA Rat Human +DTXSID3042685 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3042685 TK.Half.Life NA 1.845 hours 1compartment NA NA Rat Human +DTXSID3042685 Css NA 0.009948 mg/L 3compartmentss NA 50% Rat Human +DTXSID3042685 Css NA 0.08431 mg/L 3compartmentss NA 95% Rat Human +DTXSID3042685 Css NA 0.01064 mg/L PBTK NA 50% Rat Human +DTXSID3042685 Css NA 0.05973 mg/L PBTK NA 95% Rat Human +DTXSID30431303 Clint 14.91 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30431303 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30431303 Vd NA 0.3776 L/kg 1compartment NA NA Human Human +DTXSID30431303 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30431303 TK.Half.Life NA 0.5093 hours 1compartment NA NA Human Human +DTXSID30431303 Css NA 0.0342 mg/L 3compartmentss NA 50% Human Human +DTXSID30431303 Css NA 0.3245 mg/L 3compartmentss NA 95% Human Human +DTXSID30431303 Css NA 0.02357 mg/L PBTK NA 50% Human Human +DTXSID30431303 Css NA 0.2133 mg/L PBTK NA 95% Human Human +DTXSID30431303 Clint 14.91 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30431303 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30431303 Vd NA 0.384 L/kg 1compartment NA NA Rat Human +DTXSID30431303 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30431303 TK.Half.Life NA 0.273 hours 1compartment NA NA Rat Human +DTXSID30431303 Css NA 0.0003148 mg/L 3compartmentss NA 50% Rat Human +DTXSID30431303 Css NA 0.002773 mg/L 3compartmentss NA 95% Rat Human +DTXSID30431303 Css NA 0.0002081 mg/L PBTK NA 50% Rat Human +DTXSID30431303 Css NA 0.001682 mg/L PBTK NA 95% Rat Human +DTXSID3043734 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3043734 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3043734 Vd NA 0.4896 L/kg 1compartment NA NA Human Human +DTXSID3043734 Vd NA 0.4691 L/kg 1compartment NA NA Human Human DTXSID3043734 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3043734 TK.Half.Life NA 3.168 hours 1compartment NA NA Human Human -DTXSID3043734 Css NA 0.9328 mg/L 3compartmentss NA 50% Human Human -DTXSID3043734 Css NA 5.729 mg/L 3compartmentss NA 95% Human Human -DTXSID3043734 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID3043734 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID3043734 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3043734 TK.Half.Life NA 3.036 hours 1compartment NA NA Human Human +DTXSID3043734 Css NA 0.5144 mg/L 3compartmentss NA 50% Human Human +DTXSID3043734 Css NA 3.146 mg/L 3compartmentss NA 95% Human Human +DTXSID3043734 Css NA 0.3817 mg/L PBTK NA 50% Human Human +DTXSID3043734 Css NA 1.998 mg/L PBTK NA 95% Human Human +DTXSID3043734 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3043734 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3043734 Vd NA 0.5169 L/kg 1compartment NA NA Rat Human +DTXSID3043734 Vd NA 0.4996 L/kg 1compartment NA NA Rat Human DTXSID3043734 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3043734 TK.Half.Life NA 1.14 hours 1compartment NA NA Rat Human -DTXSID3043734 Css NA 0.2371 mg/L 3compartmentss NA 50% Rat Human -DTXSID3043734 Css NA 1.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID3043734 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID3043734 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID3043782 Clint NA 14.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3043782 Fup NA 0.0117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3043782 Vd NA 0.1856 L/kg 1compartment NA NA Human Human +DTXSID3043734 TK.Half.Life NA 1.101 hours 1compartment NA NA Rat Human +DTXSID3043734 Css NA 0.002602 mg/L 3compartmentss NA 50% Rat Human +DTXSID3043734 Css NA 0.01791 mg/L 3compartmentss NA 95% Rat Human +DTXSID3043734 Css NA 0.001866 mg/L PBTK NA 50% Rat Human +DTXSID3043734 Css NA 0.01062 mg/L PBTK NA 95% Rat Human +DTXSID3043782 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3043782 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3043782 Vd NA 0.2994 L/kg 1compartment NA NA Human Human DTXSID3043782 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3043782 TK.Half.Life NA 4.34 hours 1compartment NA NA Human Human -DTXSID3043782 Css NA 4.339 mg/L 3compartmentss NA 50% Human Human -DTXSID3043782 Css NA 40.46 mg/L 3compartmentss NA 95% Human Human -DTXSID3043782 Css NA 2.542 mg/L PBTK NA 50% Human Human -DTXSID3043782 Css NA 23.52 mg/L PBTK NA 95% Human Human -DTXSID3043782 Clint NA 14.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3043782 Fup NA 0.0117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3043782 Vd NA 0.1785 L/kg 1compartment NA NA Rat Human +DTXSID3043782 TK.Half.Life NA 3.244 hours 1compartment NA NA Human Human +DTXSID3043782 Css NA 1.552 mg/L 3compartmentss NA 50% Human Human +DTXSID3043782 Css NA 10.99 mg/L 3compartmentss NA 95% Human Human +DTXSID3043782 Css NA 0.9317 mg/L PBTK NA 50% Human Human +DTXSID3043782 Css NA 6.448 mg/L PBTK NA 95% Human Human +DTXSID3043782 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3043782 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3043782 Vd NA 0.2704 L/kg 1compartment NA NA Rat Human DTXSID3043782 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3043782 TK.Half.Life NA 2.764 hours 1compartment NA NA Rat Human -DTXSID3043782 Css NA 2.423 mg/L 3compartmentss NA 50% Rat Human -DTXSID3043782 Css NA 18.27 mg/L 3compartmentss NA 95% Rat Human -DTXSID3043782 Css NA 1.319 mg/L PBTK NA 50% Rat Human -DTXSID3043782 Css NA 9.883 mg/L PBTK NA 95% Rat Human -DTXSID3044124 Clint NA 52.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3043782 TK.Half.Life NA 1.82 hours 1compartment NA NA Rat Human +DTXSID3043782 Css NA 0.07126 mg/L 3compartmentss NA 50% Rat Human +DTXSID3043782 Css NA 0.5712 mg/L 3compartmentss NA 95% Rat Human +DTXSID3043782 Css NA 0.04094 mg/L PBTK NA 50% Rat Human +DTXSID3043782 Css NA 0.3242 mg/L PBTK NA 95% Rat Human +DTXSID3043861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3043861 Fup 0.516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3043861 Vd NA 3.13 L/kg 1compartment NA NA Human Human +DTXSID3043861 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3043861 TK.Half.Life NA 2.224 hours 1compartment NA NA Human Human +DTXSID3043861 Css NA 0.02242 mg/L 3compartmentss NA 50% Human Human +DTXSID3043861 Css NA 0.2498 mg/L 3compartmentss NA 95% Human Human +DTXSID3043861 Css NA 0.02753 mg/L PBTK NA 50% Human Human +DTXSID3043861 Css NA 0.2202 mg/L PBTK NA 95% Human Human +DTXSID3043861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3043861 Fup 0.516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3043861 Vd NA 3.137 L/kg 1compartment NA NA Rat Human +DTXSID3043861 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3043861 TK.Half.Life NA 1.188 hours 1compartment NA NA Rat Human +DTXSID3043861 Css NA 0.002613 mg/L 3compartmentss NA 50% Rat Human +DTXSID3043861 Css NA 0.02593 mg/L 3compartmentss NA 95% Rat Human +DTXSID3043861 Css NA 0.003382 mg/L PBTK NA 50% Rat Human +DTXSID3043861 Css NA 0.02198 mg/L PBTK NA 95% Rat Human +DTXSID3044122 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044122 Fup 0.037 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3044122 Vd NA 0.7973 L/kg 1compartment NA NA Human Human +DTXSID3044122 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3044122 TK.Half.Life NA 12.47 hours 1compartment NA NA Human Human +DTXSID3044122 Css NA 2.658 mg/L 3compartmentss NA 50% Human Human +DTXSID3044122 Css NA 20.19 mg/L 3compartmentss NA 95% Human Human +DTXSID3044122 Css NA 1.621 mg/L PBTK NA 50% Human Human +DTXSID3044122 Css NA 11.9 mg/L PBTK NA 95% Human Human +DTXSID3044122 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044122 Fup 0.037 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3044122 Vd NA 0.6111 L/kg 1compartment NA NA Rat Human +DTXSID3044122 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3044122 TK.Half.Life NA 5.658 hours 1compartment NA NA Rat Human +DTXSID3044122 Css NA 0.3324 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044122 Css NA 1.889 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044122 Css NA 0.1967 mg/L PBTK NA 50% Rat Human +DTXSID3044122 Css NA 1.085 mg/L PBTK NA 95% Rat Human +DTXSID3044124 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3044124 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3044124 Vd NA 1.215 L/kg 1compartment NA NA Human Human +DTXSID3044124 Vd NA 1.202 L/kg 1compartment NA NA Human Human DTXSID3044124 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044124 TK.Half.Life NA 1.708 hours 1compartment NA NA Human Human -DTXSID3044124 Css NA 0.096 mg/L 3compartmentss NA 50% Human Human -DTXSID3044124 Css NA 0.8651 mg/L 3compartmentss NA 95% Human Human -DTXSID3044124 Css NA 0.06712 mg/L PBTK NA 50% Human Human -DTXSID3044124 Css NA 0.5533 mg/L PBTK NA 95% Human Human -DTXSID3044124 Clint NA 52.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3044124 TK.Half.Life NA 6.796 hours 1compartment NA NA Human Human +DTXSID3044124 Css NA 0.7177 mg/L 3compartmentss NA 50% Human Human +DTXSID3044124 Css NA 5.192 mg/L 3compartmentss NA 95% Human Human +DTXSID3044124 Css NA 0.4996 mg/L PBTK NA 50% Human Human +DTXSID3044124 Css NA 3.253 mg/L PBTK NA 95% Human Human +DTXSID3044124 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3044124 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3044124 Vd NA 1.161 L/kg 1compartment NA NA Rat Human +DTXSID3044124 Vd NA 1.15 L/kg 1compartment NA NA Rat Human DTXSID3044124 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044124 TK.Half.Life NA 0.8832 hours 1compartment NA NA Rat Human -DTXSID3044124 Css NA 0.05475 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044124 Css NA 0.3735 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044124 Css NA 0.03613 mg/L PBTK NA 50% Rat Human -DTXSID3044124 Css NA 0.2229 mg/L PBTK NA 95% Rat Human -DTXSID3044128 Clint NA 19.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044128 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044128 Vd NA 2.824 L/kg 1compartment NA NA Human Human -DTXSID3044128 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3044128 TK.Half.Life NA 37.77 hours 1compartment NA NA Human Human -DTXSID3044128 Css NA 1.738 mg/L 3compartmentss NA 50% Human Human -DTXSID3044128 Css NA 11.11 mg/L 3compartmentss NA 95% Human Human -DTXSID3044128 Css NA 1.184 mg/L PBTK NA 50% Human Human -DTXSID3044128 Css NA 7.328 mg/L PBTK NA 95% Human Human -DTXSID3044128 Clint NA 19.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044128 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044128 Vd NA 2.114 L/kg 1compartment NA NA Rat Human -DTXSID3044128 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3044128 TK.Half.Life NA 7.316 hours 1compartment NA NA Rat Human -DTXSID3044128 Css NA 0.9702 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044128 Css NA 4.945 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044128 Css NA 0.6278 mg/L PBTK NA 50% Rat Human -DTXSID3044128 Css NA 3.149 mg/L PBTK NA 95% Rat Human -DTXSID3044201 Clint NA 38.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044201 Fup NA 0.1407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044201 Vd NA 2.135 L/kg 1compartment NA NA Human Human +DTXSID3044124 TK.Half.Life NA 3.903 hours 1compartment NA NA Rat Human +DTXSID3044124 Css NA 0.08752 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044124 Css NA 0.4887 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044124 Css NA 0.06018 mg/L PBTK NA 50% Rat Human +DTXSID3044124 Css NA 0.2974 mg/L PBTK NA 95% Rat Human +DTXSID3044201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044201 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044201 Vd NA 0.9031 L/kg 1compartment NA NA Human Human DTXSID3044201 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044201 TK.Half.Life NA 2.96 hours 1compartment NA NA Human Human -DTXSID3044201 Css NA 0.09253 mg/L 3compartmentss NA 50% Human Human -DTXSID3044201 Css NA 0.7799 mg/L 3compartmentss NA 95% Human Human -DTXSID3044201 Css NA 0.07256 mg/L PBTK NA 50% Human Human -DTXSID3044201 Css NA 0.542 mg/L PBTK NA 95% Human Human -DTXSID3044201 Clint NA 38.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044201 Fup NA 0.1407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044201 Vd NA 1.956 L/kg 1compartment NA NA Rat Human +DTXSID3044201 TK.Half.Life NA 1.343 hours 1compartment NA NA Human Human +DTXSID3044201 Css NA 0.08758 mg/L 3compartmentss NA 50% Human Human +DTXSID3044201 Css NA 0.6309 mg/L 3compartmentss NA 95% Human Human +DTXSID3044201 Css NA 0.06319 mg/L PBTK NA 50% Human Human +DTXSID3044201 Css NA 0.4222 mg/L PBTK NA 95% Human Human +DTXSID3044201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044201 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044201 Vd NA 0.9021 L/kg 1compartment NA NA Rat Human DTXSID3044201 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044201 TK.Half.Life NA 1.403 hours 1compartment NA NA Rat Human -DTXSID3044201 Css NA 0.05091 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044201 Css NA 0.341 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044201 Css NA 0.03846 mg/L PBTK NA 50% Rat Human -DTXSID3044201 Css NA 0.2306 mg/L PBTK NA 95% Rat Human +DTXSID3044201 TK.Half.Life NA 0.7394 hours 1compartment NA NA Rat Human +DTXSID3044201 Css NA 0.01121 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044201 Css NA 0.0627 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044201 Css NA 0.00801 mg/L PBTK NA 50% Rat Human +DTXSID3044201 Css NA 0.04171 mg/L PBTK NA 95% Rat Human DTXSID3044203 Clint 8.92 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3044203 Fup 0.0106 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3044203 Vd NA 0.4905 L/kg 1compartment NA NA Human Human +DTXSID3044203 Vd NA 0.5824 L/kg 1compartment NA NA Human Human DTXSID3044203 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3044203 TK.Half.Life NA 17.25 hours 1compartment NA NA Human Human -DTXSID3044203 Css NA 4.216 mg/L 3compartmentss NA 50% Human Human -DTXSID3044203 Css NA 27.79 mg/L 3compartmentss NA 95% Human Human -DTXSID3044203 Css NA 2.512 mg/L PBTK NA 50% Human Human -DTXSID3044203 Css NA 16.34 mg/L PBTK NA 95% Human Human +DTXSID3044203 TK.Half.Life NA 20.11 hours 1compartment NA NA Human Human +DTXSID3044203 Css NA 3.817 mg/L 3compartmentss NA 50% Human Human +DTXSID3044203 Css NA 24.51 mg/L 3compartmentss NA 95% Human Human +DTXSID3044203 Css NA 2.277 mg/L PBTK NA 50% Human Human +DTXSID3044203 Css NA 14.45 mg/L PBTK NA 95% Human Human DTXSID3044203 Clint 8.92 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3044203 Fup 0.0106 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3044203 Vd NA 0.3771 L/kg 1compartment NA NA Rat Human -DTXSID3044203 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044203 TK.Half.Life NA 8.473 hours 1compartment NA NA Rat Human -DTXSID3044203 Css NA 2.311 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044203 Css NA 10.85 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044203 Css NA 1.286 mg/L PBTK NA 50% Rat Human -DTXSID3044203 Css NA 5.947 mg/L PBTK NA 95% Rat Human -DTXSID3044205 Clint NA 50.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044205 Fup NA 0.099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044205 Vd NA 1.315 L/kg 1compartment NA NA Human Human +DTXSID3044203 Vd NA 0.4404 L/kg 1compartment NA NA Rat Human +DTXSID3044203 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3044203 TK.Half.Life NA 9.608 hours 1compartment NA NA Rat Human +DTXSID3044203 Css NA 0.304 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044203 Css NA 1.664 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044203 Css NA 0.1752 mg/L PBTK NA 50% Rat Human +DTXSID3044203 Css NA 0.949 mg/L PBTK NA 95% Rat Human +DTXSID3044205 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044205 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044205 Vd NA 1.503 L/kg 1compartment NA NA Human Human DTXSID3044205 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044205 TK.Half.Life NA 2.22 hours 1compartment NA NA Human Human -DTXSID3044205 Css NA 0.1365 mg/L 3compartmentss NA 50% Human Human -DTXSID3044205 Css NA 1.059 mg/L 3compartmentss NA 95% Human Human -DTXSID3044205 Css NA 0.09022 mg/L PBTK NA 50% Human Human -DTXSID3044205 Css NA 0.6542 mg/L PBTK NA 95% Human Human -DTXSID3044205 Clint NA 50.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044205 Fup NA 0.099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044205 Vd NA 1.014 L/kg 1compartment NA NA Rat Human +DTXSID3044205 TK.Half.Life NA 9.764 hours 1compartment NA NA Human Human +DTXSID3044205 Css NA 0.8513 mg/L 3compartmentss NA 50% Human Human +DTXSID3044205 Css NA 5.3 mg/L 3compartmentss NA 95% Human Human +DTXSID3044205 Css NA 0.5696 mg/L PBTK NA 50% Human Human +DTXSID3044205 Css NA 3.327 mg/L PBTK NA 95% Human Human +DTXSID3044205 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044205 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044205 Vd NA 1.156 L/kg 1compartment NA NA Rat Human DTXSID3044205 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044205 TK.Half.Life NA 0.865 hours 1compartment NA NA Rat Human -DTXSID3044205 Css NA 0.07828 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044205 Css NA 0.4762 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044205 Css NA 0.0486 mg/L PBTK NA 50% Rat Human -DTXSID3044205 Css NA 0.2834 mg/L PBTK NA 95% Rat Human -DTXSID3044251 Clint NA 26.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044251 Fup NA 0.3891 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044251 Vd NA 1.346 L/kg 1compartment NA NA Human Human +DTXSID3044205 TK.Half.Life NA 3.753 hours 1compartment NA NA Rat Human +DTXSID3044205 Css NA 0.1017 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044205 Css NA 0.509 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044205 Css NA 0.06715 mg/L PBTK NA 50% Rat Human +DTXSID3044205 Css NA 0.3045 mg/L PBTK NA 95% Rat Human +DTXSID3044209 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044209 Fup 0.0158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044209 Vd NA 1.392 L/kg 1compartment NA NA Human Human +DTXSID3044209 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3044209 TK.Half.Life NA 15.05 hours 1compartment NA NA Human Human +DTXSID3044209 Css NA 1.718 mg/L 3compartmentss NA 50% Human Human +DTXSID3044209 Css NA 15.4 mg/L 3compartmentss NA 95% Human Human +DTXSID3044209 Css NA 1.066 mg/L PBTK NA 50% Human Human +DTXSID3044209 Css NA 9.189 mg/L PBTK NA 95% Human Human +DTXSID3044209 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044209 Fup 0.0158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044209 Vd NA 1.028 L/kg 1compartment NA NA Rat Human +DTXSID3044209 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3044209 TK.Half.Life NA 5.96 hours 1compartment NA NA Rat Human +DTXSID3044209 Css NA 0.2234 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044209 Css NA 1.639 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044209 Css NA 0.1343 mg/L PBTK NA 50% Rat Human +DTXSID3044209 Css NA 0.9483 mg/L PBTK NA 95% Rat Human +DTXSID3044251 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044251 Fup 0.336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044251 Vd NA 1.245 L/kg 1compartment NA NA Human Human DTXSID3044251 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044251 TK.Half.Life NA 1.44 hours 1compartment NA NA Human Human -DTXSID3044251 Css NA 0.04663 mg/L 3compartmentss NA 50% Human Human -DTXSID3044251 Css NA 0.3692 mg/L 3compartmentss NA 95% Human Human -DTXSID3044251 Css NA 0.03666 mg/L PBTK NA 50% Human Human -DTXSID3044251 Css NA 0.2659 mg/L PBTK NA 95% Human Human -DTXSID3044251 Clint NA 26.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044251 Fup NA 0.3891 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044251 Vd NA 1.13 L/kg 1compartment NA NA Rat Human +DTXSID3044251 TK.Half.Life NA 1.552 hours 1compartment NA NA Human Human +DTXSID3044251 Css NA 0.0622 mg/L 3compartmentss NA 50% Human Human +DTXSID3044251 Css NA 0.4781 mg/L 3compartmentss NA 95% Human Human +DTXSID3044251 Css NA 0.04777 mg/L PBTK NA 50% Human Human +DTXSID3044251 Css NA 0.3408 mg/L PBTK NA 95% Human Human +DTXSID3044251 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044251 Fup 0.336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044251 Vd NA 1.043 L/kg 1compartment NA NA Rat Human DTXSID3044251 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044251 TK.Half.Life NA 0.5904 hours 1compartment NA NA Rat Human -DTXSID3044251 Css NA 0.02497 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044251 Css NA 0.1463 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044251 Css NA 0.0191 mg/L PBTK NA 50% Rat Human -DTXSID3044251 Css NA 0.1011 mg/L PBTK NA 95% Rat Human -DTXSID3044338 Clint NA 33.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044338 Fup NA 0.0549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044338 Vd NA 1.589 L/kg 1compartment NA NA Human Human +DTXSID3044251 TK.Half.Life NA 0.6545 hours 1compartment NA NA Rat Human +DTXSID3044251 Css NA 0.00771 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044251 Css NA 0.04386 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044251 Css NA 0.005893 mg/L PBTK NA 50% Rat Human +DTXSID3044251 Css NA 0.03058 mg/L PBTK NA 95% Rat Human +DTXSID3044259 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044259 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3044259 Vd NA 0.6482 L/kg 1compartment NA NA Human Human +DTXSID3044259 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3044259 TK.Half.Life NA 4.196 hours 1compartment NA NA Human Human +DTXSID3044259 Css NA 0.8223 mg/L 3compartmentss NA 50% Human Human +DTXSID3044259 Css NA 5.615 mg/L 3compartmentss NA 95% Human Human +DTXSID3044259 Css NA 0.6743 mg/L PBTK NA 50% Human Human +DTXSID3044259 Css NA 3.677 mg/L PBTK NA 95% Human Human +DTXSID3044259 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044259 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3044259 Vd NA 0.6839 L/kg 1compartment NA NA Rat Human +DTXSID3044259 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3044259 TK.Half.Life NA 1.508 hours 1compartment NA NA Rat Human +DTXSID3044259 Css NA 0.0483 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044259 Css NA 0.2914 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044259 Css NA 0.03996 mg/L PBTK NA 50% Rat Human +DTXSID3044259 Css NA 0.1803 mg/L PBTK NA 95% Rat Human +DTXSID3044338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044338 Fup 0.0994 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044338 Vd NA 1.998 L/kg 1compartment NA NA Human Human DTXSID3044338 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044338 TK.Half.Life NA 5.067 hours 1compartment NA NA Human Human -DTXSID3044338 Css NA 0.3862 mg/L 3compartmentss NA 50% Human Human -DTXSID3044338 Css NA 2.868 mg/L 3compartmentss NA 95% Human Human -DTXSID3044338 Css NA 0.2492 mg/L PBTK NA 50% Human Human -DTXSID3044338 Css NA 1.781 mg/L PBTK NA 95% Human Human -DTXSID3044338 Clint NA 33.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044338 Fup NA 0.0549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044338 Vd NA 1.195 L/kg 1compartment NA NA Rat Human +DTXSID3044338 TK.Half.Life NA 6.639 hours 1compartment NA NA Human Human +DTXSID3044338 Css NA 0.3664 mg/L 3compartmentss NA 50% Human Human +DTXSID3044338 Css NA 2.611 mg/L 3compartmentss NA 95% Human Human +DTXSID3044338 Css NA 0.2454 mg/L PBTK NA 50% Human Human +DTXSID3044338 Css NA 1.681 mg/L PBTK NA 95% Human Human +DTXSID3044338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044338 Fup 0.0994 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044338 Vd NA 1.513 L/kg 1compartment NA NA Rat Human DTXSID3044338 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044338 TK.Half.Life NA 1.893 hours 1compartment NA NA Rat Human -DTXSID3044338 Css NA 0.2174 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044338 Css NA 1.262 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044338 Css NA 0.1321 mg/L PBTK NA 50% Rat Human -DTXSID3044338 Css NA 0.7342 mg/L PBTK NA 95% Rat Human -DTXSID3044380 Clint NA 6.901 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044380 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044380 Vd NA 2.386 L/kg 1compartment NA NA Human Human -DTXSID3044380 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3044380 TK.Half.Life NA 26.15 hours 1compartment NA NA Human Human -DTXSID3044380 Css NA 1.454 mg/L 3compartmentss NA 50% Human Human -DTXSID3044380 Css NA 8.334 mg/L 3compartmentss NA 95% Human Human -DTXSID3044380 Css NA 0.9974 mg/L PBTK NA 50% Human Human -DTXSID3044380 Css NA 5.44 mg/L PBTK NA 95% Human Human -DTXSID3044380 Clint NA 6.901 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044380 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044380 Vd NA 1.798 L/kg 1compartment NA NA Rat Human -DTXSID3044380 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3044380 TK.Half.Life NA 6.87 hours 1compartment NA NA Rat Human -DTXSID3044380 Css NA 0.7636 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044380 Css NA 3.229 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044380 Css NA 0.4986 mg/L PBTK NA 50% Rat Human -DTXSID3044380 Css NA 2.007 mg/L PBTK NA 95% Rat Human -DTXSID3044382 Clint NA 4.103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044382 Fup NA 0.7939 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044382 Vd NA 1.234 L/kg 1compartment NA NA Human Human +DTXSID3044338 TK.Half.Life NA 2.206 hours 1compartment NA NA Rat Human +DTXSID3044338 Css NA 0.04682 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044338 Css NA 0.2652 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044338 Css NA 0.03108 mg/L PBTK NA 50% Rat Human +DTXSID3044338 Css NA 0.1696 mg/L PBTK NA 95% Rat Human +DTXSID3044380 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044380 Fup 0.0263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044380 Vd NA 1.539 L/kg 1compartment NA NA Human Human +DTXSID3044380 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3044380 TK.Half.Life NA 11.69 hours 1compartment NA NA Human Human +DTXSID3044380 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human +DTXSID3044380 Css NA 10.11 mg/L 3compartmentss NA 95% Human Human +DTXSID3044380 Css NA 0.7172 mg/L PBTK NA 50% Human Human +DTXSID3044380 Css NA 6.152 mg/L PBTK NA 95% Human Human +DTXSID3044380 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044380 Fup 0.0263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044380 Vd NA 1.145 L/kg 1compartment NA NA Rat Human +DTXSID3044380 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3044380 TK.Half.Life NA 4.449 hours 1compartment NA NA Rat Human +DTXSID3044380 Css NA 0.148 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044380 Css NA 1.046 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044380 Css NA 0.09073 mg/L PBTK NA 50% Rat Human +DTXSID3044380 Css NA 0.6111 mg/L PBTK NA 95% Rat Human +DTXSID3044382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044382 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044382 Vd NA 0.8155 L/kg 1compartment NA NA Human Human DTXSID3044382 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044382 TK.Half.Life NA 1.879 hours 1compartment NA NA Human Human -DTXSID3044382 Css NA 0.1278 mg/L 3compartmentss NA 50% Human Human -DTXSID3044382 Css NA 0.9929 mg/L 3compartmentss NA 95% Human Human -DTXSID3044382 Css NA 0.113 mg/L PBTK NA 50% Human Human -DTXSID3044382 Css NA 0.6935 mg/L PBTK NA 95% Human Human -DTXSID3044382 Clint NA 4.103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044382 Fup NA 0.7939 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044382 Vd NA 1.147 L/kg 1compartment NA NA Rat Human +DTXSID3044382 TK.Half.Life NA 0.9209 hours 1compartment NA NA Human Human +DTXSID3044382 Css NA 0.05018 mg/L 3compartmentss NA 50% Human Human +DTXSID3044382 Css NA 0.396 mg/L 3compartmentss NA 95% Human Human +DTXSID3044382 Css NA 0.03785 mg/L PBTK NA 50% Human Human +DTXSID3044382 Css NA 0.2714 mg/L PBTK NA 95% Human Human +DTXSID3044382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044382 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044382 Vd NA 0.7526 L/kg 1compartment NA NA Rat Human DTXSID3044382 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044382 TK.Half.Life NA 0.907 hours 1compartment NA NA Rat Human -DTXSID3044382 Css NA 0.05838 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044382 Css NA 0.4343 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044382 Css NA 0.05118 mg/L PBTK NA 50% Rat Human -DTXSID3044382 Css NA 0.2747 mg/L PBTK NA 95% Rat Human -DTXSID3044388 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044388 Fup NA 0.6329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044388 Vd NA 1.979 L/kg 1compartment NA NA Human Human -DTXSID3044388 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3044388 TK.Half.Life NA 20.23 hours 1compartment NA NA Human Human -DTXSID3044388 Css NA 0.9056 mg/L 3compartmentss NA 50% Human Human -DTXSID3044388 Css NA 6.912 mg/L 3compartmentss NA 95% Human Human -DTXSID3044388 Css NA 0.9456 mg/L PBTK NA 50% Human Human -DTXSID3044388 Css NA 4.819 mg/L PBTK NA 95% Human Human -DTXSID3044388 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044388 Fup NA 0.6329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044388 Vd NA 1.951 L/kg 1compartment NA NA Rat Human +DTXSID3044382 TK.Half.Life NA 0.4368 hours 1compartment NA NA Rat Human +DTXSID3044382 Css NA 0.006185 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044382 Css NA 0.03882 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044382 Css NA 0.004691 mg/L PBTK NA 50% Rat Human +DTXSID3044382 Css NA 0.02607 mg/L PBTK NA 95% Rat Human +DTXSID3044388 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044388 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044388 Vd NA 1.729 L/kg 1compartment NA NA Human Human +DTXSID3044388 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3044388 TK.Half.Life NA 16.17 hours 1compartment NA NA Human Human +DTXSID3044388 Css NA 0.7642 mg/L 3compartmentss NA 50% Human Human +DTXSID3044388 Css NA 5.766 mg/L 3compartmentss NA 95% Human Human +DTXSID3044388 Css NA 0.7577 mg/L PBTK NA 50% Human Human +DTXSID3044388 Css NA 3.922 mg/L PBTK NA 95% Human Human +DTXSID3044388 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044388 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044388 Vd NA 1.706 L/kg 1compartment NA NA Rat Human DTXSID3044388 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044388 TK.Half.Life NA 6.796 hours 1compartment NA NA Rat Human -DTXSID3044388 Css NA 0.2345 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044388 Css NA 1.731 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044388 Css NA 0.2404 mg/L PBTK NA 50% Rat Human -DTXSID3044388 Css NA 1.116 mg/L PBTK NA 95% Rat Human -DTXSID3044411 Clint NA 10.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044411 Fup NA 0.6128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044411 Vd NA 4.789 L/kg 1compartment NA NA Human Human -DTXSID3044411 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044411 TK.Half.Life NA 3.796 hours 1compartment NA NA Human Human -DTXSID3044411 Css NA 0.03281 mg/L 3compartmentss NA 50% Human Human -DTXSID3044411 Css NA 0.4458 mg/L 3compartmentss NA 95% Human Human -DTXSID3044411 Css NA 0.05068 mg/L PBTK NA 50% Human Human -DTXSID3044411 Css NA 0.4112 mg/L PBTK NA 95% Human Human -DTXSID3044411 Clint NA 10.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044411 Fup NA 0.6128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044411 Vd NA 4.866 L/kg 1compartment NA NA Rat Human -DTXSID3044411 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044411 TK.Half.Life NA 2.183 hours 1compartment NA NA Rat Human -DTXSID3044411 Css NA 0.0158 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044411 Css NA 0.1992 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044411 Css NA 0.02505 mg/L PBTK NA 50% Rat Human -DTXSID3044411 Css NA 0.1708 mg/L PBTK NA 95% Rat Human -DTXSID3044413 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044413 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044413 Vd NA 2.188 L/kg 1compartment NA NA Human Human +DTXSID3044388 TK.Half.Life NA 5.436 hours 1compartment NA NA Rat Human +DTXSID3044388 Css NA 0.01454 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044388 Css NA 0.1333 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044388 Css NA 0.014 mg/L PBTK NA 50% Rat Human +DTXSID3044388 Css NA 0.09289 mg/L PBTK NA 95% Rat Human +DTXSID3044411 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044411 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044411 Vd NA 3.215 L/kg 1compartment NA NA Human Human +DTXSID3044411 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID3044411 TK.Half.Life NA 39.77 hours 1compartment NA NA Human Human +DTXSID3044411 Css NA 0.8428 mg/L 3compartmentss NA 50% Human Human +DTXSID3044411 Css NA 6.461 mg/L 3compartmentss NA 95% Human Human +DTXSID3044411 Css NA 1.05 mg/L PBTK NA 50% Human Human +DTXSID3044411 Css NA 4.838 mg/L PBTK NA 95% Human Human +DTXSID3044411 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044411 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044411 Vd NA 3.244 L/kg 1compartment NA NA Rat Human +DTXSID3044411 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3044411 TK.Half.Life NA 13.66 hours 1compartment NA NA Rat Human +DTXSID3044411 Css NA 0.0505 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044411 Css NA 0.3578 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044411 Css NA 0.06447 mg/L PBTK NA 50% Rat Human +DTXSID3044411 Css NA 0.2634 mg/L PBTK NA 95% Rat Human +DTXSID3044413 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044413 Fup 0.804 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044413 Vd NA 1.884 L/kg 1compartment NA NA Human Human DTXSID3044413 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3044413 TK.Half.Life NA 14.19 hours 1compartment NA NA Human Human -DTXSID3044413 Css NA 0.6622 mg/L 3compartmentss NA 50% Human Human -DTXSID3044413 Css NA 5.388 mg/L 3compartmentss NA 95% Human Human -DTXSID3044413 Css NA 0.697 mg/L PBTK NA 50% Human Human -DTXSID3044413 Css NA 3.686 mg/L PBTK NA 95% Human Human -DTXSID3044413 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044413 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044413 Vd NA 2.226 L/kg 1compartment NA NA Rat Human +DTXSID3044413 TK.Half.Life NA 15.19 hours 1compartment NA NA Human Human +DTXSID3044413 Css NA 0.8056 mg/L 3compartmentss NA 50% Human Human +DTXSID3044413 Css NA 5.355 mg/L 3compartmentss NA 95% Human Human +DTXSID3044413 Css NA 0.7984 mg/L PBTK NA 50% Human Human +DTXSID3044413 Css NA 3.691 mg/L PBTK NA 95% Human Human +DTXSID3044413 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044413 Fup 0.804 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044413 Vd NA 1.912 L/kg 1compartment NA NA Rat Human DTXSID3044413 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044413 TK.Half.Life NA 4.909 hours 1compartment NA NA Rat Human -DTXSID3044413 Css NA 0.1638 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044413 Css NA 1.154 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044413 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID3044413 Css NA 0.7573 mg/L PBTK NA 95% Rat Human -DTXSID3044415 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044415 Fup NA 0.3833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044415 Vd NA 0.8771 L/kg 1compartment NA NA Human Human +DTXSID3044413 TK.Half.Life NA 5.247 hours 1compartment NA NA Rat Human +DTXSID3044413 Css NA 0.04666 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044413 Css NA 0.3053 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044413 Css NA 0.04708 mg/L PBTK NA 50% Rat Human +DTXSID3044413 Css NA 0.2028 mg/L PBTK NA 95% Rat Human +DTXSID3044415 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044415 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044415 Vd NA 0.3971 L/kg 1compartment NA NA Human Human DTXSID3044415 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044415 TK.Half.Life NA 1.229 hours 1compartment NA NA Human Human -DTXSID3044415 Css NA 0.08785 mg/L 3compartmentss NA 50% Human Human -DTXSID3044415 Css NA 0.6299 mg/L 3compartmentss NA 95% Human Human -DTXSID3044415 Css NA 0.06706 mg/L PBTK NA 50% Human Human -DTXSID3044415 Css NA 0.4248 mg/L PBTK NA 95% Human Human -DTXSID3044415 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044415 Fup NA 0.3833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044415 Vd NA 0.7949 L/kg 1compartment NA NA Rat Human +DTXSID3044415 TK.Half.Life NA 1.867 hours 1compartment NA NA Human Human +DTXSID3044415 Css NA 0.5993 mg/L 3compartmentss NA 50% Human Human +DTXSID3044415 Css NA 4.049 mg/L 3compartmentss NA 95% Human Human +DTXSID3044415 Css NA 0.3809 mg/L PBTK NA 50% Human Human +DTXSID3044415 Css NA 2.485 mg/L PBTK NA 95% Human Human +DTXSID3044415 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044415 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044415 Vd NA 0.38 L/kg 1compartment NA NA Rat Human DTXSID3044415 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044415 TK.Half.Life NA 0.594 hours 1compartment NA NA Rat Human -DTXSID3044415 Css NA 0.04578 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044415 Css NA 0.2593 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044415 Css NA 0.03356 mg/L PBTK NA 50% Rat Human -DTXSID3044415 Css NA 0.1697 mg/L PBTK NA 95% Rat Human -DTXSID3044461 Clint NA 2.395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044461 Fup NA 0.2989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044461 Vd NA 2.709 L/kg 1compartment NA NA Human Human -DTXSID3044461 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3044461 TK.Half.Life NA 37.9 hours 1compartment NA NA Human Human -DTXSID3044461 Css NA 1.566 mg/L 3compartmentss NA 50% Human Human -DTXSID3044461 Css NA 6.671 mg/L 3compartmentss NA 95% Human Human -DTXSID3044461 Css NA 1.161 mg/L PBTK NA 50% Human Human -DTXSID3044461 Css NA 4.656 mg/L PBTK NA 95% Human Human -DTXSID3044461 Clint NA 2.395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044461 Fup NA 0.2989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044461 Vd NA 2.069 L/kg 1compartment NA NA Rat Human -DTXSID3044461 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3044461 TK.Half.Life NA 7.616 hours 1compartment NA NA Rat Human -DTXSID3044461 Css NA 0.7474 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044461 Css NA 2.198 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044461 Css NA 0.5349 mg/L PBTK NA 50% Rat Human -DTXSID3044461 Css NA 1.426 mg/L PBTK NA 95% Rat Human +DTXSID3044415 TK.Half.Life NA 1.068 hours 1compartment NA NA Rat Human +DTXSID3044415 Css NA 0.07436 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044415 Css NA 0.3661 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044415 Css NA 0.0461 mg/L PBTK NA 50% Rat Human +DTXSID3044415 Css NA 0.2128 mg/L PBTK NA 95% Rat Human +DTXSID3044461 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044461 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044461 Vd NA 1.824 L/kg 1compartment NA NA Human Human +DTXSID3044461 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3044461 TK.Half.Life NA 2.819 hours 1compartment NA NA Human Human +DTXSID3044461 Css NA 0.0934 mg/L 3compartmentss NA 50% Human Human +DTXSID3044461 Css NA 0.6891 mg/L 3compartmentss NA 95% Human Human +DTXSID3044461 Css NA 0.0707 mg/L PBTK NA 50% Human Human +DTXSID3044461 Css NA 0.4857 mg/L PBTK NA 95% Human Human +DTXSID3044461 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044461 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044461 Vd NA 1.439 L/kg 1compartment NA NA Rat Human +DTXSID3044461 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3044461 TK.Half.Life NA 1.03 hours 1compartment NA NA Rat Human +DTXSID3044461 Css NA 0.01189 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044461 Css NA 0.06301 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044461 Css NA 0.008964 mg/L PBTK NA 50% Rat Human +DTXSID3044461 Css NA 0.04451 mg/L PBTK NA 95% Rat Human DTXSID3044465 Clint NA 0.1668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3044465 Fup NA 0.5624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3044465 Vd NA 0.4157 L/kg 1compartment NA NA Human Human DTXSID3044465 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3044465 TK.Half.Life NA 0.3809 hours 1compartment NA NA Human Human -DTXSID3044465 Css NA 0.02948 mg/L 3compartmentss NA 50% Human Human -DTXSID3044465 Css NA 0.2973 mg/L 3compartmentss NA 95% Human Human -DTXSID3044465 Css NA 0.02126 mg/L PBTK NA 50% Human Human -DTXSID3044465 Css NA 0.194 mg/L PBTK NA 95% Human Human +DTXSID3044465 Css NA 0.02092 mg/L 3compartmentss NA 50% Human Human +DTXSID3044465 Css NA 0.2483 mg/L 3compartmentss NA 95% Human Human +DTXSID3044465 Css NA 0.01499 mg/L PBTK NA 50% Human Human +DTXSID3044465 Css NA 0.1576 mg/L PBTK NA 95% Human Human DTXSID3044465 Clint NA 0.1668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3044465 Fup NA 0.5624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3044465 Vd NA 0.4504 L/kg 1compartment NA NA Rat Human DTXSID3044465 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3044465 TK.Half.Life NA 0.1982 hours 1compartment NA NA Rat Human -DTXSID3044465 Css NA 0.0154 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044465 Css NA 0.1331 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044465 Css NA 0.01069 mg/L PBTK NA 50% Rat Human -DTXSID3044465 Css NA 0.08179 mg/L PBTK NA 95% Rat Human -DTXSID3044469 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044469 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044469 Vd NA 0.8777 L/kg 1compartment NA NA Human Human +DTXSID3044465 Css NA 0.0007572 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044465 Css NA 0.009977 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044465 Css NA 0.0005303 mg/L PBTK NA 50% Rat Human +DTXSID3044465 Css NA 0.00628 mg/L PBTK NA 95% Rat Human +DTXSID3044469 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044469 Fup 0.801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044469 Vd NA 0.443 L/kg 1compartment NA NA Human Human DTXSID3044469 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044469 TK.Half.Life NA 5.682 hours 1compartment NA NA Human Human -DTXSID3044469 Css NA 0.82 mg/L 3compartmentss NA 50% Human Human -DTXSID3044469 Css NA 5.512 mg/L 3compartmentss NA 95% Human Human -DTXSID3044469 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID3044469 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID3044469 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044469 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044469 Vd NA 0.9215 L/kg 1compartment NA NA Rat Human +DTXSID3044469 TK.Half.Life NA 3.578 hours 1compartment NA NA Human Human +DTXSID3044469 Css NA 0.954 mg/L 3compartmentss NA 50% Human Human +DTXSID3044469 Css NA 5.411 mg/L 3compartmentss NA 95% Human Human +DTXSID3044469 Css NA 0.6946 mg/L PBTK NA 50% Human Human +DTXSID3044469 Css NA 3.407 mg/L PBTK NA 95% Human Human +DTXSID3044469 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044469 Fup 0.801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044469 Vd NA 0.4703 L/kg 1compartment NA NA Rat Human DTXSID3044469 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044469 TK.Half.Life NA 2.031 hours 1compartment NA NA Rat Human -DTXSID3044469 Css NA 0.2056 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044469 Css NA 1.302 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044469 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID3044469 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID3044542 Clint NA 37.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044542 Fup NA 0.2464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044542 Vd NA 1.339 L/kg 1compartment NA NA Human Human +DTXSID3044469 TK.Half.Life NA 1.295 hours 1compartment NA NA Rat Human +DTXSID3044469 Css NA 0.01797 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044469 Css NA 0.134 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044469 Css NA 0.0125 mg/L PBTK NA 50% Rat Human +DTXSID3044469 Css NA 0.08181 mg/L PBTK NA 95% Rat Human +DTXSID3044542 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044542 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044542 Vd NA 0.9941 L/kg 1compartment NA NA Human Human DTXSID3044542 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044542 TK.Half.Life NA 1.624 hours 1compartment NA NA Human Human -DTXSID3044542 Css NA 0.05874 mg/L 3compartmentss NA 50% Human Human -DTXSID3044542 Css NA 0.414 mg/L 3compartmentss NA 95% Human Human -DTXSID3044542 Css NA 0.04305 mg/L PBTK NA 50% Human Human -DTXSID3044542 Css NA 0.2832 mg/L PBTK NA 95% Human Human -DTXSID3044542 Clint NA 37.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044542 Fup NA 0.2464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044542 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID3044542 TK.Half.Life NA 1.927 hours 1compartment NA NA Human Human +DTXSID3044542 Css NA 0.1576 mg/L 3compartmentss NA 50% Human Human +DTXSID3044542 Css NA 1.188 mg/L 3compartmentss NA 95% Human Human +DTXSID3044542 Css NA 0.1071 mg/L PBTK NA 50% Human Human +DTXSID3044542 Css NA 0.7545 mg/L PBTK NA 95% Human Human +DTXSID3044542 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044542 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044542 Vd NA 0.7916 L/kg 1compartment NA NA Rat Human DTXSID3044542 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044542 TK.Half.Life NA 0.6261 hours 1compartment NA NA Rat Human -DTXSID3044542 Css NA 0.03192 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044542 Css NA 0.1757 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044542 Css NA 0.02244 mg/L PBTK NA 50% Rat Human -DTXSID3044542 Css NA 0.1169 mg/L PBTK NA 95% Rat Human -DTXSID3044544 Clint NA 11.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044544 Fup NA 0.023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044544 Vd NA 1.693 L/kg 1compartment NA NA Human Human -DTXSID3044544 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3044544 TK.Half.Life NA 25.91 hours 1compartment NA NA Human Human -DTXSID3044544 Css NA 2.468 mg/L 3compartmentss NA 50% Human Human -DTXSID3044544 Css NA 19.47 mg/L 3compartmentss NA 95% Human Human -DTXSID3044544 Css NA 1.565 mg/L PBTK NA 50% Human Human -DTXSID3044544 Css NA 12.13 mg/L PBTK NA 95% Human Human -DTXSID3044544 Clint NA 11.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044544 Fup NA 0.023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044544 Vd NA 1.258 L/kg 1compartment NA NA Rat Human -DTXSID3044544 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3044544 TK.Half.Life NA 9.289 hours 1compartment NA NA Rat Human -DTXSID3044544 Css NA 1.377 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044544 Css NA 8.571 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044544 Css NA 0.8174 mg/L PBTK NA 50% Rat Human -DTXSID3044544 Css NA 4.816 mg/L PBTK NA 95% Rat Human +DTXSID3044542 TK.Half.Life NA 0.825 hours 1compartment NA NA Rat Human +DTXSID3044542 Css NA 0.02032 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044542 Css NA 0.1199 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044542 Css NA 0.01357 mg/L PBTK NA 50% Rat Human +DTXSID3044542 Css NA 0.07445 mg/L PBTK NA 95% Rat Human +DTXSID3044544 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044544 Fup 0.0184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044544 Vd NA 2.563 L/kg 1compartment NA NA Human Human +DTXSID3044544 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3044544 TK.Half.Life NA 34.55 hours 1compartment NA NA Human Human +DTXSID3044544 Css NA 1.832 mg/L 3compartmentss NA 50% Human Human +DTXSID3044544 Css NA 14.06 mg/L 3compartmentss NA 95% Human Human +DTXSID3044544 Css NA 1.208 mg/L PBTK NA 50% Human Human +DTXSID3044544 Css NA 8.981 mg/L PBTK NA 95% Human Human +DTXSID3044544 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044544 Fup 0.0184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044544 Vd NA 1.913 L/kg 1compartment NA NA Rat Human +DTXSID3044544 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3044544 TK.Half.Life NA 8.175 hours 1compartment NA NA Rat Human +DTXSID3044544 Css NA 0.2393 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044544 Css NA 1.424 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044544 Css NA 0.1563 mg/L PBTK NA 50% Rat Human +DTXSID3044544 Css NA 0.8936 mg/L PBTK NA 95% Rat Human DTXSID3044590 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3044590 Fup 0.003 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3044590 Vd NA 0.7451 L/kg 1compartment NA NA Human Human -DTXSID3044590 Days.Css NA 476 Days PBTK NA NA Human Human -DTXSID3044590 TK.Half.Life NA 1773 hours 1compartment NA NA Human Human -DTXSID3044590 Css NA 267.2 mg/L 3compartmentss NA 50% Human Human -DTXSID3044590 Css NA 1147 mg/L 3compartmentss NA 95% Human Human -DTXSID3044590 Css NA 160.4 mg/L PBTK NA 50% Human Human -DTXSID3044590 Css NA 674.8 mg/L PBTK NA 95% Human Human +DTXSID3044590 Vd NA 1.358 L/kg 1compartment NA NA Human Human +DTXSID3044590 Days.Css NA 903 Days PBTK NA NA Human Human +DTXSID3044590 TK.Half.Life NA 3347 hours 1compartment NA NA Human Human +DTXSID3044590 Css NA 258.1 mg/L 3compartmentss NA 50% Human Human +DTXSID3044590 Css NA 1130 mg/L 3compartmentss NA 95% Human Human +DTXSID3044590 Css NA 162.2 mg/L PBTK NA 50% Human Human +DTXSID3044590 Css NA 666.1 mg/L PBTK NA 95% Human Human DTXSID3044590 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3044590 Fup 0.003 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3044590 Vd NA 0.5493 L/kg 1compartment NA NA Rat Human -DTXSID3044590 Days.Css NA 114 Days PBTK NA NA Rat Human -DTXSID3044590 TK.Half.Life NA 413.6 hours 1compartment NA NA Rat Human -DTXSID3044590 Css NA 75.37 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044590 Css NA 278.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044590 Css NA 42.36 mg/L PBTK NA 50% Rat Human -DTXSID3044590 Css NA 152 mg/L PBTK NA 95% Rat Human -DTXSID3044598 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044598 Fup NA 0.8641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044598 Vd NA 1.562 L/kg 1compartment NA NA Human Human +DTXSID3044590 Vd NA 0.9978 L/kg 1compartment NA NA Rat Human +DTXSID3044590 Days.Css NA 222 Days PBTK NA NA Rat Human +DTXSID3044590 TK.Half.Life NA 758.1 hours 1compartment NA NA Rat Human +DTXSID3044590 Css NA 16.74 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044590 Css NA 62.35 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044590 Css NA 10.23 mg/L PBTK NA 50% Rat Human +DTXSID3044590 Css NA 35.8 mg/L PBTK NA 95% Rat Human +DTXSID3044598 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044598 Fup 0.869 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044598 Vd NA 1.624 L/kg 1compartment NA NA Human Human DTXSID3044598 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3044598 TK.Half.Life NA 11.7 hours 1compartment NA NA Human Human -DTXSID3044598 Css NA 0.8173 mg/L 3compartmentss NA 50% Human Human -DTXSID3044598 Css NA 5.267 mg/L 3compartmentss NA 95% Human Human -DTXSID3044598 Css NA 0.7787 mg/L PBTK NA 50% Human Human -DTXSID3044598 Css NA 3.565 mg/L PBTK NA 95% Human Human -DTXSID3044598 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044598 Fup NA 0.8641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044598 Vd NA 1.598 L/kg 1compartment NA NA Rat Human +DTXSID3044598 TK.Half.Life NA 12.09 hours 1compartment NA NA Human Human +DTXSID3044598 Css NA 0.7051 mg/L 3compartmentss NA 50% Human Human +DTXSID3044598 Css NA 4.494 mg/L 3compartmentss NA 95% Human Human +DTXSID3044598 Css NA 0.6745 mg/L PBTK NA 50% Human Human +DTXSID3044598 Css NA 3.053 mg/L PBTK NA 95% Human Human +DTXSID3044598 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044598 Fup 0.869 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044598 Vd NA 1.659 L/kg 1compartment NA NA Rat Human DTXSID3044598 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044598 TK.Half.Life NA 4.077 hours 1compartment NA NA Rat Human -DTXSID3044598 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044598 Css NA 1.331 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044598 Css NA 0.1942 mg/L PBTK NA 50% Rat Human -DTXSID3044598 Css NA 0.8399 mg/L PBTK NA 95% Rat Human +DTXSID3044598 TK.Half.Life NA 4.209 hours 1compartment NA NA Rat Human +DTXSID3044598 Css NA 0.01781 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044598 Css NA 0.1326 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044598 Css NA 0.01672 mg/L PBTK NA 50% Rat Human +DTXSID3044598 Css NA 0.09128 mg/L PBTK NA 95% Rat Human DTXSID3044621 Clint NA 2480 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3044621 Fup NA 0.1993 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044621 Vd NA 3.487 L/kg 1compartment NA NA Human Human +DTXSID3044621 Vd NA 4.024 L/kg 1compartment NA NA Human Human DTXSID3044621 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044621 TK.Half.Life NA 1.491 hours 1compartment NA NA Human Human -DTXSID3044621 Css NA 0.000293 mg/L 3compartmentss NA 50% Human Human -DTXSID3044621 Css NA 0.002769 mg/L 3compartmentss NA 95% Human Human -DTXSID3044621 Css NA 0.0003724 mg/L PBTK NA 50% Human Human -DTXSID3044621 Css NA 0.002662 mg/L PBTK NA 95% Human Human +DTXSID3044621 TK.Half.Life NA 1.563 hours 1compartment NA NA Human Human +DTXSID3044621 Css NA 3.208e-05 mg/L 3compartmentss NA 50% Human Human +DTXSID3044621 Css NA 0.0009473 mg/L 3compartmentss NA 95% Human Human +DTXSID3044621 Css NA 4.415e-05 mg/L PBTK NA 50% Human Human +DTXSID3044621 Css NA 0.001026 mg/L PBTK NA 95% Human Human DTXSID3044621 Clint NA 2480 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3044621 Fup NA 0.1993 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044621 Vd NA 3.474 L/kg 1compartment NA NA Rat Human +DTXSID3044621 Vd NA 4.007 L/kg 1compartment NA NA Rat Human DTXSID3044621 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044621 TK.Half.Life NA 0.6527 hours 1compartment NA NA Rat Human -DTXSID3044621 Css NA 0.0001561 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044621 Css NA 0.001152 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044621 Css NA 0.0001979 mg/L PBTK NA 50% Rat Human -DTXSID3044621 Css NA 0.001151 mg/L PBTK NA 95% Rat Human -DTXSID3044623 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044623 Fup NA 0.8423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044623 Vd NA 0.6851 L/kg 1compartment NA NA Human Human +DTXSID3044621 TK.Half.Life NA 0.6829 hours 1compartment NA NA Rat Human +DTXSID3044621 Css NA 4.662e-06 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044621 Css NA 9.91e-05 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044621 Css NA 7.038e-06 mg/L PBTK NA 50% Rat Human +DTXSID3044621 Css NA 0.0001252 mg/L PBTK NA 95% Rat Human +DTXSID3044623 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044623 Fup 0.744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044623 Vd NA 0.7163 L/kg 1compartment NA NA Human Human DTXSID3044623 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044623 TK.Half.Life NA 5.291 hours 1compartment NA NA Human Human -DTXSID3044623 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human -DTXSID3044623 Css NA 5.852 mg/L 3compartmentss NA 95% Human Human -DTXSID3044623 Css NA 0.7956 mg/L PBTK NA 50% Human Human -DTXSID3044623 Css NA 3.755 mg/L PBTK NA 95% Human Human -DTXSID3044623 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044623 Fup NA 0.8423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044623 Vd NA 0.6887 L/kg 1compartment NA NA Rat Human +DTXSID3044623 TK.Half.Life NA 0.5991 hours 1compartment NA NA Human Human +DTXSID3044623 Css NA 0.02846 mg/L 3compartmentss NA 50% Human Human +DTXSID3044623 Css NA 0.2927 mg/L 3compartmentss NA 95% Human Human +DTXSID3044623 Css NA 0.0225 mg/L PBTK NA 50% Human Human +DTXSID3044623 Css NA 0.2018 mg/L PBTK NA 95% Human Human +DTXSID3044623 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044623 Fup 0.744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044623 Vd NA 0.7034 L/kg 1compartment NA NA Rat Human DTXSID3044623 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044623 TK.Half.Life NA 1.805 hours 1compartment NA NA Rat Human -DTXSID3044623 Css NA 0.2569 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044623 Css NA 1.461 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044623 Css NA 0.1975 mg/L PBTK NA 50% Rat Human -DTXSID3044623 Css NA 0.8651 mg/L PBTK NA 95% Rat Human +DTXSID3044623 TK.Half.Life NA 0.2847 hours 1compartment NA NA Rat Human +DTXSID3044623 Css NA 0.003407 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044623 Css NA 0.0309 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044623 Css NA 0.002731 mg/L PBTK NA 50% Rat Human +DTXSID3044623 Css NA 0.02053 mg/L PBTK NA 95% Rat Human DTXSID3044625 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3044625 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044625 Vd NA 0.8253 L/kg 1compartment NA NA Human Human +DTXSID3044625 Vd NA 0.857 L/kg 1compartment NA NA Human Human DTXSID3044625 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044625 TK.Half.Life NA 5.34 hours 1compartment NA NA Human Human -DTXSID3044625 Css NA 0.8206 mg/L 3compartmentss NA 50% Human Human -DTXSID3044625 Css NA 5.544 mg/L 3compartmentss NA 95% Human Human -DTXSID3044625 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID3044625 Css NA 3.572 mg/L PBTK NA 95% Human Human +DTXSID3044625 TK.Half.Life NA 5.55 hours 1compartment NA NA Human Human +DTXSID3044625 Css NA 0.6894 mg/L 3compartmentss NA 50% Human Human +DTXSID3044625 Css NA 4.893 mg/L 3compartmentss NA 95% Human Human +DTXSID3044625 Css NA 0.5918 mg/L PBTK NA 50% Human Human +DTXSID3044625 Css NA 3.169 mg/L PBTK NA 95% Human Human DTXSID3044625 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3044625 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044625 Vd NA 0.8616 L/kg 1compartment NA NA Rat Human +DTXSID3044625 Vd NA 0.8889 L/kg 1compartment NA NA Rat Human DTXSID3044625 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044625 TK.Half.Life NA 1.9 hours 1compartment NA NA Rat Human -DTXSID3044625 Css NA 0.2062 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044625 Css NA 1.326 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044625 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID3044625 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID3044627 Clint NA 0.00459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044627 Fup NA 0.1982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044627 Vd NA 0.2836 L/kg 1compartment NA NA Human Human +DTXSID3044625 TK.Half.Life NA 1.96 hours 1compartment NA NA Rat Human +DTXSID3044625 Css NA 0.01255 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044625 Css NA 0.101 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044625 Css NA 0.01047 mg/L PBTK NA 50% Rat Human +DTXSID3044625 Css NA 0.06698 mg/L PBTK NA 95% Rat Human +DTXSID3044627 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044627 Fup 0.647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044627 Vd NA 0.5674 L/kg 1compartment NA NA Human Human DTXSID3044627 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044627 TK.Half.Life NA 9.186 hours 1compartment NA NA Human Human -DTXSID3044627 Css NA 4.108 mg/L 3compartmentss NA 50% Human Human -DTXSID3044627 Css NA 14.73 mg/L 3compartmentss NA 95% Human Human -DTXSID3044627 Css NA 2.624 mg/L PBTK NA 50% Human Human -DTXSID3044627 Css NA 8.755 mg/L PBTK NA 95% Human Human -DTXSID3044627 Clint NA 0.00459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044627 Fup NA 0.1982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044627 Vd NA 0.2857 L/kg 1compartment NA NA Rat Human +DTXSID3044627 TK.Half.Life NA 5.672 hours 1compartment NA NA Human Human +DTXSID3044627 Css NA 1.156 mg/L 3compartmentss NA 50% Human Human +DTXSID3044627 Css NA 7.173 mg/L 3compartmentss NA 95% Human Human +DTXSID3044627 Css NA 0.906 mg/L PBTK NA 50% Human Human +DTXSID3044627 Css NA 4.566 mg/L PBTK NA 95% Human Human +DTXSID3044627 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044627 Fup 0.647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044627 Vd NA 0.5756 L/kg 1compartment NA NA Rat Human DTXSID3044627 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044627 TK.Half.Life NA 3.167 hours 1compartment NA NA Rat Human -DTXSID3044627 Css NA 1.156 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044627 Css NA 3.518 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044627 Css NA 0.6926 mg/L PBTK NA 50% Rat Human -DTXSID3044627 Css NA 1.973 mg/L PBTK NA 95% Rat Human -DTXSID3044629 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044629 Fup NA 0.4002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044629 Vd NA 0.4407 L/kg 1compartment NA NA Human Human +DTXSID3044627 TK.Half.Life NA 1.961 hours 1compartment NA NA Rat Human +DTXSID3044627 Css NA 0.06937 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044627 Css NA 0.4207 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044627 Css NA 0.05431 mg/L PBTK NA 50% Rat Human +DTXSID3044627 Css NA 0.2554 mg/L PBTK NA 95% Rat Human +DTXSID3044629 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044629 Fup 0.533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044629 Vd NA 0.6671 L/kg 1compartment NA NA Human Human DTXSID3044629 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044629 TK.Half.Life NA 7.124 hours 1compartment NA NA Human Human -DTXSID3044629 Css NA 1.872 mg/L 3compartmentss NA 50% Human Human -DTXSID3044629 Css NA 8.169 mg/L 3compartmentss NA 95% Human Human -DTXSID3044629 Css NA 1.334 mg/L PBTK NA 50% Human Human -DTXSID3044629 Css NA 5.157 mg/L PBTK NA 95% Human Human -DTXSID3044629 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044629 Fup NA 0.4002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044629 Vd NA 0.4621 L/kg 1compartment NA NA Rat Human +DTXSID3044629 TK.Half.Life NA 8.097 hours 1compartment NA NA Human Human +DTXSID3044629 Css NA 0.7131 mg/L 3compartmentss NA 50% Human Human +DTXSID3044629 Css NA 4.56 mg/L 3compartmentss NA 95% Human Human +DTXSID3044629 Css NA 0.5797 mg/L PBTK NA 50% Human Human +DTXSID3044629 Css NA 2.946 mg/L PBTK NA 95% Human Human +DTXSID3044629 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044629 Fup 0.533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044629 Vd NA 0.6798 L/kg 1compartment NA NA Rat Human DTXSID3044629 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044629 TK.Half.Life NA 2.546 hours 1compartment NA NA Rat Human -DTXSID3044629 Css NA 0.5108 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044629 Css NA 1.888 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044629 Css NA 0.3473 mg/L PBTK NA 50% Rat Human -DTXSID3044629 Css NA 1.103 mg/L PBTK NA 95% Rat Human -DTXSID3044679 Clint NA 2.069 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044679 Fup NA 0.2625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044679 Vd NA 0.5287 L/kg 1compartment NA NA Human Human +DTXSID3044629 TK.Half.Life NA 2.812 hours 1compartment NA NA Rat Human +DTXSID3044629 Css NA 0.003764 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044629 Css NA 0.02439 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044629 Css NA 0.002924 mg/L PBTK NA 50% Rat Human +DTXSID3044629 Css NA 0.01487 mg/L PBTK NA 95% Rat Human +DTXSID3044679 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044679 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044679 Vd NA 0.5093 L/kg 1compartment NA NA Human Human DTXSID3044679 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044679 TK.Half.Life NA 3.171 hours 1compartment NA NA Human Human -DTXSID3044679 Css NA 0.6412 mg/L 3compartmentss NA 50% Human Human -DTXSID3044679 Css NA 3.289 mg/L 3compartmentss NA 95% Human Human -DTXSID3044679 Css NA 0.4634 mg/L PBTK NA 50% Human Human -DTXSID3044679 Css NA 2.142 mg/L PBTK NA 95% Human Human -DTXSID3044679 Clint NA 2.069 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044679 Fup NA 0.2625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044679 Vd NA 0.5311 L/kg 1compartment NA NA Rat Human +DTXSID3044679 TK.Half.Life NA 7.372 hours 1compartment NA NA Human Human +DTXSID3044679 Css NA 1.572 mg/L 3compartmentss NA 50% Human Human +DTXSID3044679 Css NA 7.389 mg/L 3compartmentss NA 95% Human Human +DTXSID3044679 Css NA 1.169 mg/L PBTK NA 50% Human Human +DTXSID3044679 Css NA 4.634 mg/L PBTK NA 95% Human Human +DTXSID3044679 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044679 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044679 Vd NA 0.5294 L/kg 1compartment NA NA Rat Human DTXSID3044679 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044679 TK.Half.Life NA 1.737 hours 1compartment NA NA Rat Human -DTXSID3044679 Css NA 0.2956 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044679 Css NA 1.125 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044679 Css NA 0.203 mg/L PBTK NA 50% Rat Human -DTXSID3044679 Css NA 0.6745 mg/L PBTK NA 95% Rat Human -DTXSID3044702 Clint NA 12.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044702 Fup NA 0.0924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044702 Vd NA 1.405 L/kg 1compartment NA NA Human Human +DTXSID3044679 TK.Half.Life NA 2.612 hours 1compartment NA NA Rat Human +DTXSID3044679 Css NA 0.1011 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044679 Css NA 0.405 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044679 Css NA 0.07381 mg/L PBTK NA 50% Rat Human +DTXSID3044679 Css NA 0.2474 mg/L PBTK NA 95% Rat Human +DTXSID3044702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044702 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044702 Vd NA 1.509 L/kg 1compartment NA NA Human Human DTXSID3044702 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044702 TK.Half.Life NA 6.086 hours 1compartment NA NA Human Human -DTXSID3044702 Css NA 0.559 mg/L 3compartmentss NA 50% Human Human -DTXSID3044702 Css NA 4.065 mg/L 3compartmentss NA 95% Human Human -DTXSID3044702 Css NA 0.3683 mg/L PBTK NA 50% Human Human -DTXSID3044702 Css NA 2.546 mg/L PBTK NA 95% Human Human -DTXSID3044702 Clint NA 12.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044702 Fup NA 0.0924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044702 Vd NA 1.074 L/kg 1compartment NA NA Rat Human +DTXSID3044702 TK.Half.Life NA 3.87 hours 1compartment NA NA Human Human +DTXSID3044702 Css NA 0.2618 mg/L 3compartmentss NA 50% Human Human +DTXSID3044702 Css NA 1.934 mg/L 3compartmentss NA 95% Human Human +DTXSID3044702 Css NA 0.1748 mg/L PBTK NA 50% Human Human +DTXSID3044702 Css NA 1.208 mg/L PBTK NA 95% Human Human +DTXSID3044702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044702 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044702 Vd NA 1.158 L/kg 1compartment NA NA Rat Human DTXSID3044702 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044702 TK.Half.Life NA 2.423 hours 1compartment NA NA Rat Human -DTXSID3044702 Css NA 0.3064 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044702 Css NA 1.709 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044702 Css NA 0.1896 mg/L PBTK NA 50% Rat Human -DTXSID3044702 Css NA 1.011 mg/L PBTK NA 95% Rat Human +DTXSID3044702 TK.Half.Life NA 1.491 hours 1compartment NA NA Rat Human +DTXSID3044702 Css NA 0.03317 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044702 Css NA 0.205 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044702 Css NA 0.02176 mg/L PBTK NA 50% Rat Human +DTXSID3044702 Css NA 0.1247 mg/L PBTK NA 95% Rat Human DTXSID3044704 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3044704 Fup 0.00511 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3044704 Vd NA 0.1716 L/kg 1compartment NA NA Human Human -DTXSID3044704 Days.Css NA 52 Days PBTK NA NA Human Human -DTXSID3044704 TK.Half.Life NA 217.2 hours 1compartment NA NA Human Human -DTXSID3044704 Css NA 205.2 mg/L 3compartmentss NA 50% Human Human -DTXSID3044704 Css NA 1212 mg/L 3compartmentss NA 95% Human Human -DTXSID3044704 Css NA 119.3 mg/L PBTK NA 50% Human Human -DTXSID3044704 Css NA 700.7 mg/L PBTK NA 95% Human Human +DTXSID3044704 Vd NA 0.82 L/kg 1compartment NA NA Human Human +DTXSID3044704 Days.Css NA 312 Days PBTK NA NA Human Human +DTXSID3044704 TK.Half.Life NA 1168 hours 1compartment NA NA Human Human +DTXSID3044704 Css NA 189.7 mg/L 3compartmentss NA 50% Human Human +DTXSID3044704 Css NA 1073 mg/L 3compartmentss NA 95% Human Human +DTXSID3044704 Css NA 114.2 mg/L PBTK NA 50% Human Human +DTXSID3044704 Css NA 622.2 mg/L PBTK NA 95% Human Human DTXSID3044704 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3044704 Fup 0.00511 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3044704 Vd NA 0.1695 L/kg 1compartment NA NA Rat Human -DTXSID3044704 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID3044704 TK.Half.Life NA 73.16 hours 1compartment NA NA Rat Human -DTXSID3044704 Css NA 58.97 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044704 Css NA 297.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044704 Css NA 31.99 mg/L PBTK NA 50% Rat Human -DTXSID3044704 Css NA 161 mg/L PBTK NA 95% Rat Human -DTXSID3044706 Clint NA 0.2579 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044706 Fup NA 0.897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044706 Vd NA 1.032 L/kg 1compartment NA NA Human Human +DTXSID3044704 Vd NA 0.6029 L/kg 1compartment NA NA Rat Human +DTXSID3044704 Days.Css NA 72 Days PBTK NA NA Rat Human +DTXSID3044704 TK.Half.Life NA 267.9 hours 1compartment NA NA Rat Human +DTXSID3044704 Css NA 3.612 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044704 Css NA 27.58 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044704 Css NA 2.032 mg/L PBTK NA 50% Rat Human +DTXSID3044704 Css NA 15.49 mg/L PBTK NA 95% Rat Human +DTXSID3044706 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044706 Fup 0.818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044706 Vd NA 0.573 L/kg 1compartment NA NA Human Human DTXSID3044706 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044706 TK.Half.Life NA 5.267 hours 1compartment NA NA Human Human -DTXSID3044706 Css NA 0.6138 mg/L 3compartmentss NA 50% Human Human -DTXSID3044706 Css NA 3.643 mg/L 3compartmentss NA 95% Human Human -DTXSID3044706 Css NA 0.528 mg/L PBTK NA 50% Human Human -DTXSID3044706 Css NA 2.385 mg/L PBTK NA 95% Human Human -DTXSID3044706 Clint NA 0.2579 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044706 Fup NA 0.897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044706 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID3044706 TK.Half.Life NA 4.539 hours 1compartment NA NA Human Human +DTXSID3044706 Css NA 1.015 mg/L 3compartmentss NA 50% Human Human +DTXSID3044706 Css NA 5.828 mg/L 3compartmentss NA 95% Human Human +DTXSID3044706 Css NA 0.7812 mg/L PBTK NA 50% Human Human +DTXSID3044706 Css NA 3.666 mg/L PBTK NA 95% Human Human +DTXSID3044706 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044706 Fup 0.818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044706 Vd NA 0.5871 L/kg 1compartment NA NA Rat Human DTXSID3044706 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044706 TK.Half.Life NA 2.172 hours 1compartment NA NA Rat Human -DTXSID3044706 Css NA 0.1853 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044706 Css NA 1.054 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044706 Css NA 0.1567 mg/L PBTK NA 50% Rat Human -DTXSID3044706 Css NA 0.649 mg/L PBTK NA 95% Rat Human -DTXSID3044750 Clint NA 14.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044750 Fup NA 0.4745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044750 Vd NA 1.642 L/kg 1compartment NA NA Human Human +DTXSID3044706 TK.Half.Life NA 1.583 hours 1compartment NA NA Rat Human +DTXSID3044706 Css NA 0.06057 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044706 Css NA 0.3481 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044706 Css NA 0.04647 mg/L PBTK NA 50% Rat Human +DTXSID3044706 Css NA 0.2104 mg/L PBTK NA 95% Rat Human +DTXSID3044750 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044750 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044750 Vd NA 1.164 L/kg 1compartment NA NA Human Human DTXSID3044750 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044750 TK.Half.Life NA 2.064 hours 1compartment NA NA Human Human -DTXSID3044750 Css NA 0.07226 mg/L 3compartmentss NA 50% Human Human -DTXSID3044750 Css NA 0.5633 mg/L 3compartmentss NA 95% Human Human -DTXSID3044750 Css NA 0.05914 mg/L PBTK NA 50% Human Human -DTXSID3044750 Css NA 0.4092 mg/L PBTK NA 95% Human Human -DTXSID3044750 Clint NA 14.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044750 Fup NA 0.4745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044750 Vd NA 1.36 L/kg 1compartment NA NA Rat Human +DTXSID3044750 TK.Half.Life NA 3.711 hours 1compartment NA NA Human Human +DTXSID3044750 Css NA 0.2966 mg/L 3compartmentss NA 50% Human Human +DTXSID3044750 Css NA 1.756 mg/L 3compartmentss NA 95% Human Human +DTXSID3044750 Css NA 0.2147 mg/L PBTK NA 50% Human Human +DTXSID3044750 Css NA 1.172 mg/L PBTK NA 95% Human Human +DTXSID3044750 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044750 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044750 Vd NA 0.9572 L/kg 1compartment NA NA Rat Human DTXSID3044750 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044750 TK.Half.Life NA 0.8226 hours 1compartment NA NA Rat Human -DTXSID3044750 Css NA 0.0375 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044750 Css NA 0.2277 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044750 Css NA 0.03024 mg/L PBTK NA 50% Rat Human -DTXSID3044750 Css NA 0.1579 mg/L PBTK NA 95% Rat Human -DTXSID3044752 Clint NA 0.6988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044752 Fup NA 0.4621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044752 Vd NA 1.148 L/kg 1compartment NA NA Human Human -DTXSID3044752 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044752 TK.Half.Life NA 8.251 hours 1compartment NA NA Human Human -DTXSID3044752 Css NA 0.716 mg/L 3compartmentss NA 50% Human Human -DTXSID3044752 Css NA 3.602 mg/L 3compartmentss NA 95% Human Human -DTXSID3044752 Css NA 0.5822 mg/L PBTK NA 50% Human Human -DTXSID3044752 Css NA 2.434 mg/L PBTK NA 95% Human Human -DTXSID3044752 Clint NA 0.6988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044752 Fup NA 0.4621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044752 Vd NA 1.009 L/kg 1compartment NA NA Rat Human +DTXSID3044750 TK.Half.Life NA 1.639 hours 1compartment NA NA Rat Human +DTXSID3044750 Css NA 0.03488 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044750 Css NA 0.1519 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044750 Css NA 0.0252 mg/L PBTK NA 50% Rat Human +DTXSID3044750 Css NA 0.09895 mg/L PBTK NA 95% Rat Human +DTXSID3044752 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044752 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044752 Vd NA 1.172 L/kg 1compartment NA NA Human Human +DTXSID3044752 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3044752 TK.Half.Life NA 20.74 hours 1compartment NA NA Human Human +DTXSID3044752 Css NA 1.78 mg/L 3compartmentss NA 50% Human Human +DTXSID3044752 Css NA 7.768 mg/L 3compartmentss NA 95% Human Human +DTXSID3044752 Css NA 1.418 mg/L PBTK NA 50% Human Human +DTXSID3044752 Css NA 5.114 mg/L PBTK NA 95% Human Human +DTXSID3044752 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044752 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044752 Vd NA 1.012 L/kg 1compartment NA NA Rat Human DTXSID3044752 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044752 TK.Half.Life NA 3.155 hours 1compartment NA NA Rat Human -DTXSID3044752 Css NA 0.2718 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044752 Css NA 1.225 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044752 Css NA 0.2133 mg/L PBTK NA 50% Rat Human -DTXSID3044752 Css NA 0.7525 mg/L PBTK NA 95% Rat Human -DTXSID3044758 Clint NA 1.904 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044758 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044758 Vd NA 0.7315 L/kg 1compartment NA NA Human Human -DTXSID3044758 Days.Css NA 29 Days PBTK NA NA Human Human -DTXSID3044758 TK.Half.Life NA 136 hours 1compartment NA NA Human Human -DTXSID3044758 Css NA 33.82 mg/L 3compartmentss NA 50% Human Human -DTXSID3044758 Css NA 237.3 mg/L 3compartmentss NA 95% Human Human -DTXSID3044758 Css NA 20.1 mg/L PBTK NA 50% Human Human -DTXSID3044758 Css NA 137.9 mg/L PBTK NA 95% Human Human -DTXSID3044758 Clint NA 1.904 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044758 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044758 Vd NA 0.5414 L/kg 1compartment NA NA Rat Human -DTXSID3044758 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID3044758 TK.Half.Life NA 54.97 hours 1compartment NA NA Rat Human -DTXSID3044758 Css NA 16.18 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044758 Css NA 94.81 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044758 Css NA 8.987 mg/L PBTK NA 50% Rat Human -DTXSID3044758 Css NA 51.6 mg/L PBTK NA 95% Rat Human -DTXSID3044831 Clint NA 107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044831 Fup NA 0.2033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044831 Vd NA 0.8679 L/kg 1compartment NA NA Human Human +DTXSID3044752 TK.Half.Life NA 5.622 hours 1compartment NA NA Rat Human +DTXSID3044752 Css NA 0.1128 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044752 Css NA 0.4443 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044752 Css NA 0.0893 mg/L PBTK NA 50% Rat Human +DTXSID3044752 Css NA 0.2815 mg/L PBTK NA 95% Rat Human +DTXSID3044758 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044758 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044758 Vd NA 2.868 L/kg 1compartment NA NA Human Human +DTXSID3044758 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3044758 TK.Half.Life NA 50.97 hours 1compartment NA NA Human Human +DTXSID3044758 Css NA 1.989 mg/L 3compartmentss NA 50% Human Human +DTXSID3044758 Css NA 14.34 mg/L 3compartmentss NA 95% Human Human +DTXSID3044758 Css NA 1.349 mg/L PBTK NA 50% Human Human +DTXSID3044758 Css NA 9.45 mg/L PBTK NA 95% Human Human +DTXSID3044758 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044758 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044758 Vd NA 2.143 L/kg 1compartment NA NA Rat Human +DTXSID3044758 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID3044758 TK.Half.Life NA 9.337 hours 1compartment NA NA Rat Human +DTXSID3044758 Css NA 0.1034 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044758 Css NA 0.7513 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044758 Css NA 0.06796 mg/L PBTK NA 50% Rat Human +DTXSID3044758 Css NA 0.4702 mg/L PBTK NA 95% Rat Human +DTXSID3044831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044831 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044831 Vd NA 2.58 L/kg 1compartment NA NA Human Human DTXSID3044831 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044831 TK.Half.Life NA 0.8428 hours 1compartment NA NA Human Human -DTXSID3044831 Css NA 0.02319 mg/L 3compartmentss NA 50% Human Human -DTXSID3044831 Css NA 0.1765 mg/L 3compartmentss NA 95% Human Human -DTXSID3044831 Css NA 0.01623 mg/L PBTK NA 50% Human Human -DTXSID3044831 Css NA 0.1164 mg/L PBTK NA 95% Human Human -DTXSID3044831 Clint NA 107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044831 Fup NA 0.2033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044831 Vd NA 0.7338 L/kg 1compartment NA NA Rat Human +DTXSID3044831 TK.Half.Life NA 5.188 hours 1compartment NA NA Human Human +DTXSID3044831 Css NA 0.1486 mg/L 3compartmentss NA 50% Human Human +DTXSID3044831 Css NA 0.9212 mg/L 3compartmentss NA 95% Human Human +DTXSID3044831 Css NA 0.1116 mg/L PBTK NA 50% Human Human +DTXSID3044831 Css NA 0.6543 mg/L PBTK NA 95% Human Human +DTXSID3044831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044831 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044831 Vd NA 1.984 L/kg 1compartment NA NA Rat Human DTXSID3044831 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044831 TK.Half.Life NA 0.3375 hours 1compartment NA NA Rat Human -DTXSID3044831 Css NA 0.01311 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044831 Css NA 0.07677 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044831 Css NA 0.008685 mg/L PBTK NA 50% Rat Human -DTXSID3044831 Css NA 0.04769 mg/L PBTK NA 95% Rat Human -DTXSID3044835 Clint NA 7.253 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044835 Fup NA 0.0201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044835 Vd NA 1.726 L/kg 1compartment NA NA Human Human -DTXSID3044835 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID3044835 TK.Half.Life NA 44.75 hours 1compartment NA NA Human Human -DTXSID3044835 Css NA 4.216 mg/L 3compartmentss NA 50% Human Human -DTXSID3044835 Css NA 32.45 mg/L 3compartmentss NA 95% Human Human -DTXSID3044835 Css NA 2.673 mg/L PBTK NA 50% Human Human -DTXSID3044835 Css NA 19.74 mg/L PBTK NA 95% Human Human -DTXSID3044835 Clint NA 7.253 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044835 Fup NA 0.0201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044835 Vd NA 1.281 L/kg 1compartment NA NA Rat Human -DTXSID3044835 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3044835 TK.Half.Life NA 15.6 hours 1compartment NA NA Rat Human -DTXSID3044835 Css NA 2.331 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044835 Css NA 13.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044835 Css NA 1.384 mg/L PBTK NA 50% Rat Human -DTXSID3044835 Css NA 7.585 mg/L PBTK NA 95% Rat Human -DTXSID3044837 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044837 Fup NA 0.7916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044837 Vd NA 2.225 L/kg 1compartment NA NA Human Human -DTXSID3044837 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044837 TK.Half.Life NA 2.926 hours 1compartment NA NA Human Human -DTXSID3044837 Css NA 0.09698 mg/L 3compartmentss NA 50% Human Human -DTXSID3044837 Css NA 0.8589 mg/L 3compartmentss NA 95% Human Human -DTXSID3044837 Css NA 0.1031 mg/L PBTK NA 50% Human Human -DTXSID3044837 Css NA 0.661 mg/L PBTK NA 95% Human Human -DTXSID3044837 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044837 Fup NA 0.7916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044837 Vd NA 2.214 L/kg 1compartment NA NA Rat Human +DTXSID3044831 TK.Half.Life NA 1.446 hours 1compartment NA NA Rat Human +DTXSID3044831 Css NA 0.01843 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044831 Css NA 0.09266 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044831 Css NA 0.01391 mg/L PBTK NA 50% Rat Human +DTXSID3044831 Css NA 0.06657 mg/L PBTK NA 95% Rat Human +DTXSID3044833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044833 Fup 0.0688 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044833 Vd NA 3.07 L/kg 1compartment NA NA Human Human +DTXSID3044833 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3044833 TK.Half.Life NA 48.78 hours 1compartment NA NA Human Human +DTXSID3044833 Css NA 1.874 mg/L 3compartmentss NA 50% Human Human +DTXSID3044833 Css NA 11.9 mg/L 3compartmentss NA 95% Human Human +DTXSID3044833 Css NA 1.296 mg/L PBTK NA 50% Human Human +DTXSID3044833 Css NA 8.051 mg/L PBTK NA 95% Human Human +DTXSID3044833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044833 Fup 0.0688 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044833 Vd NA 2.302 L/kg 1compartment NA NA Rat Human +DTXSID3044833 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3044833 TK.Half.Life NA 7.27 hours 1compartment NA NA Rat Human +DTXSID3044833 Css NA 0.2385 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044833 Css NA 1.352 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044833 Css NA 0.1646 mg/L PBTK NA 50% Rat Human +DTXSID3044833 Css NA 0.9112 mg/L PBTK NA 95% Rat Human +DTXSID3044835 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044835 Fup 0.0443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044835 Vd NA 1.335 L/kg 1compartment NA NA Human Human +DTXSID3044835 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3044835 TK.Half.Life NA 19.18 hours 1compartment NA NA Human Human +DTXSID3044835 Css NA 2.262 mg/L 3compartmentss NA 50% Human Human +DTXSID3044835 Css NA 15.89 mg/L 3compartmentss NA 95% Human Human +DTXSID3044835 Css NA 1.437 mg/L PBTK NA 50% Human Human +DTXSID3044835 Css NA 9.675 mg/L PBTK NA 95% Human Human +DTXSID3044835 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044835 Fup 0.0443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044835 Vd NA 1.004 L/kg 1compartment NA NA Rat Human +DTXSID3044835 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3044835 TK.Half.Life NA 7.583 hours 1compartment NA NA Rat Human +DTXSID3044835 Css NA 0.2764 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044835 Css NA 1.52 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044835 Css NA 0.1698 mg/L PBTK NA 50% Rat Human +DTXSID3044835 Css NA 0.8873 mg/L PBTK NA 95% Rat Human +DTXSID3044837 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044837 Fup 0.708 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044837 Vd NA 1.606 L/kg 1compartment NA NA Human Human +DTXSID3044837 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3044837 TK.Half.Life NA 14.68 hours 1compartment NA NA Human Human +DTXSID3044837 Css NA 0.8829 mg/L 3compartmentss NA 50% Human Human +DTXSID3044837 Css NA 6.403 mg/L 3compartmentss NA 95% Human Human +DTXSID3044837 Css NA 0.8522 mg/L PBTK NA 50% Human Human +DTXSID3044837 Css NA 4.372 mg/L PBTK NA 95% Human Human +DTXSID3044837 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044837 Fup 0.708 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044837 Vd NA 1.597 L/kg 1compartment NA NA Rat Human DTXSID3044837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044837 TK.Half.Life NA 1.601 hours 1compartment NA NA Rat Human -DTXSID3044837 Css NA 0.04408 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044837 Css NA 0.3725 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044837 Css NA 0.0474 mg/L PBTK NA 50% Rat Human -DTXSID3044837 Css NA 0.2572 mg/L PBTK NA 95% Rat Human -DTXSID3044881 Clint NA 804.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044881 Fup NA 0.3139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044881 Vd NA 1.045 L/kg 1compartment NA NA Human Human -DTXSID3044881 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044881 TK.Half.Life NA 0.7531 hours 1compartment NA NA Human Human -DTXSID3044881 Css NA 0.00181 mg/L 3compartmentss NA 50% Human Human -DTXSID3044881 Css NA 0.01487 mg/L 3compartmentss NA 95% Human Human -DTXSID3044881 Css NA 0.001382 mg/L PBTK NA 50% Human Human -DTXSID3044881 Css NA 0.01018 mg/L PBTK NA 95% Human Human -DTXSID3044881 Clint NA 804.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044881 Fup NA 0.3139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044881 Vd NA 1.044 L/kg 1compartment NA NA Rat Human +DTXSID3044837 TK.Half.Life NA 4.972 hours 1compartment NA NA Rat Human +DTXSID3044837 Css NA 0.05191 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044837 Css NA 0.385 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044837 Css NA 0.05096 mg/L PBTK NA 50% Rat Human +DTXSID3044837 Css NA 0.2488 mg/L PBTK NA 95% Rat Human +DTXSID3044881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044881 Fup 0.523 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044881 Vd NA 2.063 L/kg 1compartment NA NA Human Human +DTXSID3044881 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3044881 TK.Half.Life NA 26.55 hours 1compartment NA NA Human Human +DTXSID3044881 Css NA 1.121 mg/L 3compartmentss NA 50% Human Human +DTXSID3044881 Css NA 6.935 mg/L 3compartmentss NA 95% Human Human +DTXSID3044881 Css NA 1.086 mg/L PBTK NA 50% Human Human +DTXSID3044881 Css NA 4.81 mg/L PBTK NA 95% Human Human +DTXSID3044881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044881 Fup 0.523 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044881 Vd NA 2.043 L/kg 1compartment NA NA Rat Human DTXSID3044881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044881 TK.Half.Life NA 0.3305 hours 1compartment NA NA Rat Human -DTXSID3044881 Css NA 0.0009826 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044881 Css NA 0.00659 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044881 Css NA 0.0007304 mg/L PBTK NA 50% Rat Human -DTXSID3044881 Css NA 0.004449 mg/L PBTK NA 95% Rat Human -DTXSID3044883 Clint NA 0.07408 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044883 Fup NA 0.5147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044883 Vd NA 0.6272 L/kg 1compartment NA NA Human Human +DTXSID3044881 TK.Half.Life NA 8.698 hours 1compartment NA NA Rat Human +DTXSID3044881 Css NA 0.06764 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044881 Css NA 0.3978 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044881 Css NA 0.06676 mg/L PBTK NA 50% Rat Human +DTXSID3044881 Css NA 0.2655 mg/L PBTK NA 95% Rat Human +DTXSID3044883 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044883 Fup 0.617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044883 Vd NA 0.6303 L/kg 1compartment NA NA Human Human DTXSID3044883 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044883 TK.Half.Life NA 7.051 hours 1compartment NA NA Human Human -DTXSID3044883 Css NA 1.244 mg/L 3compartmentss NA 50% Human Human -DTXSID3044883 Css NA 6.753 mg/L 3compartmentss NA 95% Human Human -DTXSID3044883 Css NA 0.9563 mg/L PBTK NA 50% Human Human -DTXSID3044883 Css NA 4.294 mg/L PBTK NA 95% Human Human -DTXSID3044883 Clint NA 0.07408 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044883 Fup NA 0.5147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044883 Vd NA 0.6347 L/kg 1compartment NA NA Rat Human +DTXSID3044883 TK.Half.Life NA 6.614 hours 1compartment NA NA Human Human +DTXSID3044883 Css NA 1.192 mg/L 3compartmentss NA 50% Human Human +DTXSID3044883 Css NA 8.106 mg/L 3compartmentss NA 95% Human Human +DTXSID3044883 Css NA 0.9386 mg/L PBTK NA 50% Human Human +DTXSID3044883 Css NA 4.997 mg/L PBTK NA 95% Human Human +DTXSID3044883 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044883 Fup 0.617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044883 Vd NA 0.6502 L/kg 1compartment NA NA Rat Human DTXSID3044883 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044883 TK.Half.Life NA 2.568 hours 1compartment NA NA Rat Human -DTXSID3044883 Css NA 0.361 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044883 Css NA 1.773 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044883 Css NA 0.266 mg/L PBTK NA 50% Rat Human -DTXSID3044883 Css NA 1.046 mg/L PBTK NA 95% Rat Human -DTXSID3044887 Clint NA 3.746 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044887 Fup NA 0.0267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044887 Vd NA 1.174 L/kg 1compartment NA NA Human Human -DTXSID3044887 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3044887 TK.Half.Life NA 39.63 hours 1compartment NA NA Human Human -DTXSID3044887 Css NA 5.873 mg/L 3compartmentss NA 50% Human Human -DTXSID3044887 Css NA 43.96 mg/L 3compartmentss NA 95% Human Human -DTXSID3044887 Css NA 3.617 mg/L PBTK NA 50% Human Human -DTXSID3044887 Css NA 26.08 mg/L PBTK NA 95% Human Human -DTXSID3044887 Clint NA 3.746 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044887 Fup NA 0.0267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044887 Vd NA 0.8765 L/kg 1compartment NA NA Rat Human -DTXSID3044887 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3044887 TK.Half.Life NA 15.71 hours 1compartment NA NA Rat Human -DTXSID3044887 Css NA 2.976 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044887 Css NA 16.76 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044887 Css NA 1.729 mg/L PBTK NA 50% Rat Human -DTXSID3044887 Css NA 9.207 mg/L PBTK NA 95% Rat Human -DTXSID3044910 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044910 Fup NA 0.9588 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044910 Vd NA 0.9621 L/kg 1compartment NA NA Human Human +DTXSID3044883 TK.Half.Life NA 2.324 hours 1compartment NA NA Rat Human +DTXSID3044883 Css NA 0.07249 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044883 Css NA 0.4569 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044883 Css NA 0.05672 mg/L PBTK NA 50% Rat Human +DTXSID3044883 Css NA 0.2763 mg/L PBTK NA 95% Rat Human +DTXSID3044887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044887 Fup 0.0354 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044887 Vd NA 1.62 L/kg 1compartment NA NA Human Human +DTXSID3044887 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3044887 TK.Half.Life NA 10.07 hours 1compartment NA NA Human Human +DTXSID3044887 Css NA 0.8793 mg/L 3compartmentss NA 50% Human Human +DTXSID3044887 Css NA 6.255 mg/L 3compartmentss NA 95% Human Human +DTXSID3044887 Css NA 0.5605 mg/L PBTK NA 50% Human Human +DTXSID3044887 Css NA 3.911 mg/L PBTK NA 95% Human Human +DTXSID3044887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044887 Fup 0.0354 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044887 Vd NA 1.21 L/kg 1compartment NA NA Rat Human +DTXSID3044887 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3044887 TK.Half.Life NA 3.741 hours 1compartment NA NA Rat Human +DTXSID3044887 Css NA 0.1123 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044887 Css NA 0.6499 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044887 Css NA 0.06964 mg/L PBTK NA 50% Rat Human +DTXSID3044887 Css NA 0.3883 mg/L PBTK NA 95% Rat Human +DTXSID3044889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044889 Fup 0.0677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044889 Vd NA 3.081 L/kg 1compartment NA NA Human Human +DTXSID3044889 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID3044889 TK.Half.Life NA 52.63 hours 1compartment NA NA Human Human +DTXSID3044889 Css NA 1.989 mg/L 3compartmentss NA 50% Human Human +DTXSID3044889 Css NA 12.84 mg/L 3compartmentss NA 95% Human Human +DTXSID3044889 Css NA 1.392 mg/L PBTK NA 50% Human Human +DTXSID3044889 Css NA 8.753 mg/L PBTK NA 95% Human Human +DTXSID3044889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044889 Fup 0.0677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044889 Vd NA 2.311 L/kg 1compartment NA NA Rat Human +DTXSID3044889 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID3044889 TK.Half.Life NA 7.691 hours 1compartment NA NA Rat Human +DTXSID3044889 Css NA 0.259 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044889 Css NA 1.433 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044889 Css NA 0.1783 mg/L PBTK NA 50% Rat Human +DTXSID3044889 Css NA 0.9793 mg/L PBTK NA 95% Rat Human +DTXSID3044910 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044910 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044910 Vd NA 0.8246 L/kg 1compartment NA NA Human Human DTXSID3044910 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044910 TK.Half.Life NA 6.558 hours 1compartment NA NA Human Human -DTXSID3044910 Css NA 0.856 mg/L 3compartmentss NA 50% Human Human -DTXSID3044910 Css NA 4.889 mg/L 3compartmentss NA 95% Human Human -DTXSID3044910 Css NA 0.7498 mg/L PBTK NA 50% Human Human -DTXSID3044910 Css NA 3.258 mg/L PBTK NA 95% Human Human -DTXSID3044910 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044910 Fup NA 0.9588 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044910 Vd NA 0.9663 L/kg 1compartment NA NA Rat Human +DTXSID3044910 TK.Half.Life NA 6.849 hours 1compartment NA NA Human Human +DTXSID3044910 Css NA 0.8366 mg/L 3compartmentss NA 50% Human Human +DTXSID3044910 Css NA 5.45 mg/L 3compartmentss NA 95% Human Human +DTXSID3044910 Css NA 0.7032 mg/L PBTK NA 50% Human Human +DTXSID3044910 Css NA 3.528 mg/L PBTK NA 95% Human Human +DTXSID3044910 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044910 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044910 Vd NA 0.832 L/kg 1compartment NA NA Rat Human DTXSID3044910 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044910 TK.Half.Life NA 2.227 hours 1compartment NA NA Rat Human -DTXSID3044910 Css NA 0.2166 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044910 Css NA 1.182 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044910 Css NA 0.1846 mg/L PBTK NA 50% Rat Human -DTXSID3044910 Css NA 0.7318 mg/L PBTK NA 95% Rat Human -DTXSID3044914 Clint NA 4.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044914 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044914 Vd NA 0.2255 L/kg 1compartment NA NA Human Human -DTXSID3044914 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3044914 TK.Half.Life NA 10.04 hours 1compartment NA NA Human Human -DTXSID3044914 Css NA 8.185 mg/L 3compartmentss NA 50% Human Human -DTXSID3044914 Css NA 67.82 mg/L 3compartmentss NA 95% Human Human -DTXSID3044914 Css NA 4.868 mg/L PBTK NA 50% Human Human -DTXSID3044914 Css NA 39.52 mg/L PBTK NA 95% Human Human -DTXSID3044914 Clint NA 4.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044914 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044914 Vd NA 0.2203 L/kg 1compartment NA NA Rat Human -DTXSID3044914 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044914 TK.Half.Life NA 6.08 hours 1compartment NA NA Rat Human -DTXSID3044914 Css NA 4.209 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044914 Css NA 27.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044914 Css NA 2.326 mg/L PBTK NA 50% Rat Human -DTXSID3044914 Css NA 14.92 mg/L PBTK NA 95% Rat Human -DTXSID3044916 Clint NA 0.09503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044916 Fup NA 0.3597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044916 Vd NA 0.6365 L/kg 1compartment NA NA Human Human -DTXSID3044916 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3044916 TK.Half.Life NA 10.08 hours 1compartment NA NA Human Human -DTXSID3044916 Css NA 1.775 mg/L 3compartmentss NA 50% Human Human -DTXSID3044916 Css NA 7.125 mg/L 3compartmentss NA 95% Human Human -DTXSID3044916 Css NA 1.28 mg/L PBTK NA 50% Human Human -DTXSID3044916 Css NA 4.502 mg/L PBTK NA 95% Human Human -DTXSID3044916 Clint NA 0.09503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044916 Fup NA 0.3597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044916 Vd NA 0.5904 L/kg 1compartment NA NA Rat Human +DTXSID3044910 TK.Half.Life NA 2.343 hours 1compartment NA NA Rat Human +DTXSID3044910 Css NA 0.01575 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044910 Css NA 0.1265 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044910 Css NA 0.01284 mg/L PBTK NA 50% Rat Human +DTXSID3044910 Css NA 0.08375 mg/L PBTK NA 95% Rat Human +DTXSID3044914 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044914 Fup 0.0795 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044914 Vd NA 0.3948 L/kg 1compartment NA NA Human Human +DTXSID3044914 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID3044914 TK.Half.Life NA 32.13 hours 1compartment NA NA Human Human +DTXSID3044914 Css NA 12.15 mg/L 3compartmentss NA 50% Human Human +DTXSID3044914 Css NA 57.49 mg/L 3compartmentss NA 95% Human Human +DTXSID3044914 Css NA 7.726 mg/L PBTK NA 50% Human Human +DTXSID3044914 Css NA 33.92 mg/L PBTK NA 95% Human Human +DTXSID3044914 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044914 Fup 0.0795 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044914 Vd NA 0.388 L/kg 1compartment NA NA Rat Human +DTXSID3044914 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3044914 TK.Half.Life NA 10.76 hours 1compartment NA NA Rat Human +DTXSID3044914 Css NA 0.7919 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044914 Css NA 3.094 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044914 Css NA 0.4903 mg/L PBTK NA 50% Rat Human +DTXSID3044914 Css NA 1.782 mg/L PBTK NA 95% Rat Human +DTXSID3044916 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044916 Fup 0.572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044916 Vd NA 2.04 L/kg 1compartment NA NA Human Human +DTXSID3044916 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3044916 TK.Half.Life NA 23.93 hours 1compartment NA NA Human Human +DTXSID3044916 Css NA 1.036 mg/L 3compartmentss NA 50% Human Human +DTXSID3044916 Css NA 8.361 mg/L 3compartmentss NA 95% Human Human +DTXSID3044916 Css NA 1.022 mg/L PBTK NA 50% Human Human +DTXSID3044916 Css NA 5.671 mg/L PBTK NA 95% Human Human +DTXSID3044916 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044916 Fup 0.572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044916 Vd NA 2.024 L/kg 1compartment NA NA Rat Human DTXSID3044916 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044916 TK.Half.Life NA 3.376 hours 1compartment NA NA Rat Human -DTXSID3044916 Css NA 0.5257 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044916 Css NA 1.932 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044916 Css NA 0.3631 mg/L PBTK NA 50% Rat Human -DTXSID3044916 Css NA 1.135 mg/L PBTK NA 95% Rat Human -DTXSID3044960 Clint NA 12.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044960 Fup NA 0.0797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044960 Vd NA 1.884 L/kg 1compartment NA NA Human Human +DTXSID3044916 TK.Half.Life NA 7.869 hours 1compartment NA NA Rat Human +DTXSID3044916 Css NA 0.06302 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044916 Css NA 0.4648 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044916 Css NA 0.0625 mg/L PBTK NA 50% Rat Human +DTXSID3044916 Css NA 0.3015 mg/L PBTK NA 95% Rat Human +DTXSID3044960 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044960 Fup 0.0807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044960 Vd NA 1.249 L/kg 1compartment NA NA Human Human DTXSID3044960 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3044960 TK.Half.Life NA 10.93 hours 1compartment NA NA Human Human -DTXSID3044960 Css NA 0.7747 mg/L 3compartmentss NA 50% Human Human -DTXSID3044960 Css NA 5.225 mg/L 3compartmentss NA 95% Human Human -DTXSID3044960 Css NA 0.5167 mg/L PBTK NA 50% Human Human -DTXSID3044960 Css NA 3.337 mg/L PBTK NA 95% Human Human -DTXSID3044960 Clint NA 12.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044960 Fup NA 0.0797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044960 Vd NA 1.423 L/kg 1compartment NA NA Rat Human +DTXSID3044960 TK.Half.Life NA 3.945 hours 1compartment NA NA Human Human +DTXSID3044960 Css NA 0.3659 mg/L 3compartmentss NA 50% Human Human +DTXSID3044960 Css NA 2.849 mg/L 3compartmentss NA 95% Human Human +DTXSID3044960 Css NA 0.2371 mg/L PBTK NA 50% Human Human +DTXSID3044960 Css NA 1.767 mg/L PBTK NA 95% Human Human +DTXSID3044960 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044960 Fup 0.0807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044960 Vd NA 0.9589 L/kg 1compartment NA NA Rat Human DTXSID3044960 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044960 TK.Half.Life NA 3.727 hours 1compartment NA NA Rat Human -DTXSID3044960 Css NA 0.421 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044960 Css NA 2.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044960 Css NA 0.2662 mg/L PBTK NA 50% Rat Human -DTXSID3044960 Css NA 1.284 mg/L PBTK NA 95% Rat Human -DTXSID3044962 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044962 Fup NA 0.2613 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044962 Vd NA 0.6547 L/kg 1compartment NA NA Human Human -DTXSID3044962 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3044962 TK.Half.Life NA 16.59 hours 1compartment NA NA Human Human -DTXSID3044962 Css NA 2.949 mg/L 3compartmentss NA 50% Human Human -DTXSID3044962 Css NA 11.21 mg/L 3compartmentss NA 95% Human Human -DTXSID3044962 Css NA 2.071 mg/L PBTK NA 50% Human Human -DTXSID3044962 Css NA 7.059 mg/L PBTK NA 95% Human Human -DTXSID3044962 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044962 Fup NA 0.2613 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044962 Vd NA 0.6014 L/kg 1compartment NA NA Rat Human +DTXSID3044960 TK.Half.Life NA 1.629 hours 1compartment NA NA Rat Human +DTXSID3044960 Css NA 0.04784 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044960 Css NA 0.2825 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044960 Css NA 0.03025 mg/L PBTK NA 50% Rat Human +DTXSID3044960 Css NA 0.1717 mg/L PBTK NA 95% Rat Human +DTXSID3044962 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044962 Fup 0.184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044962 Vd NA 0.5391 L/kg 1compartment NA NA Human Human +DTXSID3044962 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3044962 TK.Half.Life NA 2.042 hours 1compartment NA NA Human Human +DTXSID3044962 Css NA 0.3878 mg/L 3compartmentss NA 50% Human Human +DTXSID3044962 Css NA 2.358 mg/L 3compartmentss NA 95% Human Human +DTXSID3044962 Css NA 0.2578 mg/L PBTK NA 50% Human Human +DTXSID3044962 Css NA 1.484 mg/L PBTK NA 95% Human Human +DTXSID3044962 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044962 Fup 0.184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044962 Vd NA 0.4949 L/kg 1compartment NA NA Rat Human DTXSID3044962 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3044962 TK.Half.Life NA 5.1 hours 1compartment NA NA Rat Human -DTXSID3044962 Css NA 0.81 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044962 Css NA 2.596 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044962 Css NA 0.5441 mg/L PBTK NA 50% Rat Human -DTXSID3044962 Css NA 1.524 mg/L PBTK NA 95% Rat Human -DTXSID3044966 Clint NA 18.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044966 Fup NA 0.0274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3044966 Vd NA 3.058 L/kg 1compartment NA NA Human Human -DTXSID3044966 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID3044966 TK.Half.Life NA 76.66 hours 1compartment NA NA Human Human -DTXSID3044966 Css NA 3.128 mg/L 3compartmentss NA 50% Human Human -DTXSID3044966 Css NA 20.66 mg/L 3compartmentss NA 95% Human Human -DTXSID3044966 Css NA 2.158 mg/L PBTK NA 50% Human Human -DTXSID3044966 Css NA 13.73 mg/L PBTK NA 95% Human Human -DTXSID3044966 Clint NA 18.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044966 Fup NA 0.0274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3044966 Vd NA 2.291 L/kg 1compartment NA NA Rat Human -DTXSID3044966 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID3044966 TK.Half.Life NA 11.28 hours 1compartment NA NA Rat Human -DTXSID3044966 Css NA 1.743 mg/L 3compartmentss NA 50% Rat Human -DTXSID3044966 Css NA 9.245 mg/L 3compartmentss NA 95% Rat Human -DTXSID3044966 Css NA 1.15 mg/L PBTK NA 50% Rat Human -DTXSID3044966 Css NA 6.087 mg/L PBTK NA 95% Rat Human -DTXSID3045140 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045140 Fup NA 0.0594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045140 Vd NA 1.937 L/kg 1compartment NA NA Human Human -DTXSID3045140 Days.Css NA 85 Days PBTK NA NA Human Human -DTXSID3045140 TK.Half.Life NA 365.4 hours 1compartment NA NA Human Human -DTXSID3045140 Css NA 26.95 mg/L 3compartmentss NA 50% Human Human -DTXSID3045140 Css NA 100.1 mg/L 3compartmentss NA 95% Human Human -DTXSID3045140 Css NA 17.8 mg/L PBTK NA 50% Human Human -DTXSID3045140 Css NA 61.01 mg/L PBTK NA 95% Human Human -DTXSID3045140 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045140 Fup NA 0.0594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045140 Vd NA 1.479 L/kg 1compartment NA NA Rat Human -DTXSID3045140 Days.Css NA 20 Days PBTK NA NA Rat Human -DTXSID3045140 TK.Half.Life NA 64.48 hours 1compartment NA NA Rat Human -DTXSID3045140 Css NA 7.43 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045140 Css NA 23.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045140 Css NA 4.658 mg/L PBTK NA 50% Rat Human -DTXSID3045140 Css NA 13.33 mg/L PBTK NA 95% Rat Human -DTXSID3045144 Clint NA 5.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045144 Fup NA 0.6584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045144 Vd NA 14.89 L/kg 1compartment NA NA Human Human -DTXSID3045144 Days.Css NA 397 Days PBTK NA NA Human Human -DTXSID3045144 TK.Half.Life NA 1557 hours 1compartment NA NA Human Human -DTXSID3045144 Css NA 5.46 mg/L 3compartmentss NA 50% Human Human -DTXSID3045144 Css NA 33.69 mg/L 3compartmentss NA 95% Human Human -DTXSID3045144 Css NA 8.869 mg/L PBTK NA 50% Human Human -DTXSID3045144 Css NA 50.61 mg/L PBTK NA 95% Human Human -DTXSID3045144 Clint NA 5.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045144 Fup NA 0.6584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045144 Vd NA 11.93 L/kg 1compartment NA NA Rat Human -DTXSID3045144 Days.Css NA 230 Days PBTK NA NA Rat Human -DTXSID3045144 TK.Half.Life NA 209.5 hours 1compartment NA NA Rat Human -DTXSID3045144 Css NA 2.852 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045144 Css NA 13.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045144 Css NA 4.764 mg/L PBTK NA 50% Rat Human -DTXSID3045144 Css NA 21.28 mg/L PBTK NA 95% Rat Human -DTXSID3045190 Clint NA 8.254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045190 Fup NA 0.4579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045190 Vd NA 3.344 L/kg 1compartment NA NA Human Human +DTXSID3044962 TK.Half.Life NA 1.099 hours 1compartment NA NA Rat Human +DTXSID3044962 Css NA 0.04671 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044962 Css NA 0.1997 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044962 Css NA 0.0308 mg/L PBTK NA 50% Rat Human +DTXSID3044962 Css NA 0.1206 mg/L PBTK NA 95% Rat Human +DTXSID3044966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044966 Fup 0.0302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3044966 Vd NA 2.595 L/kg 1compartment NA NA Human Human +DTXSID3044966 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3044966 TK.Half.Life NA 27.17 hours 1compartment NA NA Human Human +DTXSID3044966 Css NA 1.407 mg/L 3compartmentss NA 50% Human Human +DTXSID3044966 Css NA 10.09 mg/L 3compartmentss NA 95% Human Human +DTXSID3044966 Css NA 0.941 mg/L PBTK NA 50% Human Human +DTXSID3044966 Css NA 6.476 mg/L PBTK NA 95% Human Human +DTXSID3044966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044966 Fup 0.0302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3044966 Vd NA 1.94 L/kg 1compartment NA NA Rat Human +DTXSID3044966 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3044966 TK.Half.Life NA 6.353 hours 1compartment NA NA Rat Human +DTXSID3044966 Css NA 0.1799 mg/L 3compartmentss NA 50% Rat Human +DTXSID3044966 Css NA 1.042 mg/L 3compartmentss NA 95% Rat Human +DTXSID3044966 Css NA 0.1182 mg/L PBTK NA 50% Rat Human +DTXSID3044966 Css NA 0.66 mg/L PBTK NA 95% Rat Human +DTXSID3045140 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045140 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045140 Vd NA 1.595 L/kg 1compartment NA NA Human Human +DTXSID3045140 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3045140 TK.Half.Life NA 8.052 hours 1compartment NA NA Human Human +DTXSID3045140 Css NA 0.5868 mg/L 3compartmentss NA 50% Human Human +DTXSID3045140 Css NA 3.769 mg/L 3compartmentss NA 95% Human Human +DTXSID3045140 Css NA 0.4126 mg/L PBTK NA 50% Human Human +DTXSID3045140 Css NA 2.445 mg/L PBTK NA 95% Human Human +DTXSID3045140 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045140 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045140 Vd NA 1.289 L/kg 1compartment NA NA Rat Human +DTXSID3045140 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3045140 TK.Half.Life NA 3.304 hours 1compartment NA NA Rat Human +DTXSID3045140 Css NA 0.07017 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045140 Css NA 0.3386 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045140 Css NA 0.04866 mg/L PBTK NA 50% Rat Human +DTXSID3045140 Css NA 0.2135 mg/L PBTK NA 95% Rat Human +DTXSID3045144 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045144 Fup 0.0178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045144 Vd NA 9.225 L/kg 1compartment NA NA Human Human +DTXSID3045144 Days.Css NA 54 Days PBTK NA NA Human Human +DTXSID3045144 TK.Half.Life NA 268.5 hours 1compartment NA NA Human Human +DTXSID3045144 Css NA 2.141 mg/L 3compartmentss NA 50% Human Human +DTXSID3045144 Css NA 13.44 mg/L 3compartmentss NA 95% Human Human +DTXSID3045144 Css NA 2.415 mg/L PBTK NA 50% Human Human +DTXSID3045144 Css NA 14.22 mg/L PBTK NA 95% Human Human +DTXSID3045144 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045144 Fup 0.0178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045144 Vd NA 7.239 L/kg 1compartment NA NA Rat Human +DTXSID3045144 Days.Css NA 33 Days PBTK NA NA Rat Human +DTXSID3045144 TK.Half.Life NA 37.33 hours 1compartment NA NA Rat Human +DTXSID3045144 Css NA 0.2672 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045144 Css NA 1.326 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045144 Css NA 0.3089 mg/L PBTK NA 50% Rat Human +DTXSID3045144 Css NA 1.536 mg/L PBTK NA 95% Rat Human +DTXSID3045190 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045190 Fup 0.486 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045190 Vd NA 1.601 L/kg 1compartment NA NA Human Human DTXSID3045190 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045190 TK.Half.Life NA 4.501 hours 1compartment NA NA Human Human -DTXSID3045190 Css NA 0.07297 mg/L 3compartmentss NA 50% Human Human -DTXSID3045190 Css NA 0.624 mg/L 3compartmentss NA 95% Human Human -DTXSID3045190 Css NA 0.08548 mg/L PBTK NA 50% Human Human -DTXSID3045190 Css NA 0.5474 mg/L PBTK NA 95% Human Human -DTXSID3045190 Clint NA 8.254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045190 Fup NA 0.4579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045190 Vd NA 3.368 L/kg 1compartment NA NA Rat Human +DTXSID3045190 TK.Half.Life NA 2.656 hours 1compartment NA NA Human Human +DTXSID3045190 Css NA 0.1141 mg/L 3compartmentss NA 50% Human Human +DTXSID3045190 Css NA 0.9155 mg/L 3compartmentss NA 95% Human Human +DTXSID3045190 Css NA 0.1029 mg/L PBTK NA 50% Human Human +DTXSID3045190 Css NA 0.6619 mg/L PBTK NA 95% Human Human +DTXSID3045190 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045190 Fup 0.486 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045190 Vd NA 1.617 L/kg 1compartment NA NA Rat Human DTXSID3045190 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045190 TK.Half.Life NA 2.526 hours 1compartment NA NA Rat Human -DTXSID3045190 Css NA 0.03652 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045190 Css NA 0.2703 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045190 Css NA 0.04254 mg/L PBTK NA 50% Rat Human -DTXSID3045190 Css NA 0.2093 mg/L PBTK NA 95% Rat Human -DTXSID3045192 Clint NA 5.343 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3045190 TK.Half.Life NA 1.504 hours 1compartment NA NA Rat Human +DTXSID3045190 Css NA 0.01278 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045190 Css NA 0.08455 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045190 Css NA 0.01174 mg/L PBTK NA 50% Rat Human +DTXSID3045190 Css NA 0.05837 mg/L PBTK NA 95% Rat Human +DTXSID3045192 Clint 10 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID3045192 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3045192 Vd NA 0.4852 L/kg 1compartment NA NA Human Human +DTXSID3045192 Vd NA 0.6304 L/kg 1compartment NA NA Human Human DTXSID3045192 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045192 TK.Half.Life NA 7.815 hours 1compartment NA NA Human Human -DTXSID3045192 Css NA 0.889 mg/L 3compartmentss NA 50% Human Human -DTXSID3045192 Css NA 11.78 mg/L 3compartmentss NA 95% Human Human -DTXSID3045192 Css NA 1.252 mg/L PBTK NA 50% Human Human -DTXSID3045192 Css NA 9.809 mg/L PBTK NA 95% Human Human -DTXSID3045192 Clint NA 5.343 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3045192 TK.Half.Life NA 5.757 hours 1compartment NA NA Human Human +DTXSID3045192 Css NA 0.576 mg/L 3compartmentss NA 50% Human Human +DTXSID3045192 Css NA 4.833 mg/L 3compartmentss NA 95% Human Human +DTXSID3045192 Css NA 0.979 mg/L PBTK NA 50% Human Human +DTXSID3045192 Css NA 8.216 mg/L PBTK NA 95% Human Human +DTXSID3045192 Clint 10 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID3045192 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3045192 Vd NA 0.3951 L/kg 1compartment NA NA Rat Human +DTXSID3045192 Vd NA 0.4953 L/kg 1compartment NA NA Rat Human DTXSID3045192 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045192 TK.Half.Life NA 3.943 hours 1compartment NA NA Rat Human -DTXSID3045192 Css NA 0.6297 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045192 Css NA 6.912 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045192 Css NA 0.882 mg/L PBTK NA 50% Rat Human -DTXSID3045192 Css NA 5.168 mg/L PBTK NA 95% Rat Human -DTXSID3045194 Clint NA 67.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3045192 TK.Half.Life NA 2.849 hours 1compartment NA NA Rat Human +DTXSID3045192 Css NA 0.06901 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045192 Css NA 0.4454 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045192 Css NA 0.1215 mg/L PBTK NA 50% Rat Human +DTXSID3045192 Css NA 0.7839 mg/L PBTK NA 95% Rat Human +DTXSID3045194 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3045194 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID3045194 Vd NA 2.292 L/kg 1compartment NA NA Human Human -DTXSID3045194 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045194 TK.Half.Life NA 1.103 hours 1compartment NA NA Human Human -DTXSID3045194 Css NA 0.006373 mg/L 3compartmentss NA 50% Human Human -DTXSID3045194 Css NA 0.0548 mg/L 3compartmentss NA 95% Human Human -DTXSID3045194 Css NA 0.006769 mg/L PBTK NA 50% Human Human -DTXSID3045194 Css NA 0.04883 mg/L PBTK NA 95% Human Human -DTXSID3045194 Clint NA 67.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3045194 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3045194 TK.Half.Life NA 16.48 hours 1compartment NA NA Human Human +DTXSID3045194 Css NA 0.6543 mg/L 3compartmentss NA 50% Human Human +DTXSID3045194 Css NA 2.965 mg/L 3compartmentss NA 95% Human Human +DTXSID3045194 Css NA 0.7206 mg/L PBTK NA 50% Human Human +DTXSID3045194 Css NA 2.362 mg/L PBTK NA 95% Human Human +DTXSID3045194 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3045194 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID3045194 Vd NA 2.287 L/kg 1compartment NA NA Rat Human DTXSID3045194 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045194 TK.Half.Life NA 0.5056 hours 1compartment NA NA Rat Human -DTXSID3045194 Css NA 0.003223 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045194 Css NA 0.02512 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045194 Css NA 0.003502 mg/L PBTK NA 50% Rat Human -DTXSID3045194 Css NA 0.02279 mg/L PBTK NA 95% Rat Human -DTXSID3045196 Clint NA 46.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3045194 TK.Half.Life NA 5.603 hours 1compartment NA NA Rat Human +DTXSID3045194 Css NA 0.038 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045194 Css NA 0.1586 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045194 Css NA 0.04324 mg/L PBTK NA 50% Rat Human +DTXSID3045194 Css NA 0.1216 mg/L PBTK NA 95% Rat Human +DTXSID3045196 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID3045196 Fup 0.38 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3045196 Vd NA 2.848 L/kg 1compartment NA NA Human Human -DTXSID3045196 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045196 TK.Half.Life NA 4.201 hours 1compartment NA NA Human Human -DTXSID3045196 Css NA 0.08916 mg/L 3compartmentss NA 50% Human Human -DTXSID3045196 Css NA 0.5804 mg/L 3compartmentss NA 95% Human Human -DTXSID3045196 Css NA 0.06759 mg/L PBTK NA 50% Human Human -DTXSID3045196 Css NA 0.4165 mg/L PBTK NA 95% Human Human -DTXSID3045196 Clint NA 46.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3045196 Vd NA 2.84 L/kg 1compartment NA NA Human Human +DTXSID3045196 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3045196 TK.Half.Life NA 17.1 hours 1compartment NA NA Human Human +DTXSID3045196 Css NA 0.5994 mg/L 3compartmentss NA 50% Human Human +DTXSID3045196 Css NA 3.206 mg/L 3compartmentss NA 95% Human Human +DTXSID3045196 Css NA 0.4566 mg/L PBTK NA 50% Human Human +DTXSID3045196 Css NA 2.287 mg/L PBTK NA 95% Human Human +DTXSID3045196 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID3045196 Fup 0.38 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3045196 Vd NA 2.194 L/kg 1compartment NA NA Rat Human +DTXSID3045196 Vd NA 2.19 L/kg 1compartment NA NA Rat Human DTXSID3045196 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045196 TK.Half.Life NA 1.134 hours 1compartment NA NA Rat Human -DTXSID3045196 Css NA 0.04837 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045196 Css NA 0.2496 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045196 Css NA 0.03554 mg/L PBTK NA 50% Rat Human -DTXSID3045196 Css NA 0.171 mg/L PBTK NA 95% Rat Human -DTXSID3045198 Clint NA 54.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045198 Fup NA 0.1081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045198 Vd NA 2.349 L/kg 1compartment NA NA Human Human -DTXSID3045198 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045198 TK.Half.Life NA 4.671 hours 1compartment NA NA Human Human -DTXSID3045198 Css NA 0.1675 mg/L 3compartmentss NA 50% Human Human -DTXSID3045198 Css NA 1.225 mg/L 3compartmentss NA 95% Human Human -DTXSID3045198 Css NA 0.1157 mg/L PBTK NA 50% Human Human -DTXSID3045198 Css NA 0.808 mg/L PBTK NA 95% Human Human -DTXSID3045198 Clint NA 54.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045198 Fup NA 0.1081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045198 Vd NA 1.778 L/kg 1compartment NA NA Rat Human -DTXSID3045198 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045198 TK.Half.Life NA 1.403 hours 1compartment NA NA Rat Human -DTXSID3045198 Css NA 0.0956 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045198 Css NA 0.5275 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045198 Css NA 0.06239 mg/L PBTK NA 50% Rat Human -DTXSID3045198 Css NA 0.3296 mg/L PBTK NA 95% Rat Human -DTXSID3045221 Clint NA 9.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045221 Fup NA 0.5232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045221 Vd NA 3.919 L/kg 1compartment NA NA Human Human +DTXSID3045196 TK.Half.Life NA 3.677 hours 1compartment NA NA Rat Human +DTXSID3045196 Css NA 0.07175 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045196 Css NA 0.275 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045196 Css NA 0.05463 mg/L PBTK NA 50% Rat Human +DTXSID3045196 Css NA 0.194 mg/L PBTK NA 95% Rat Human +DTXSID3045198 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045198 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045198 Vd NA 2.314 L/kg 1compartment NA NA Human Human +DTXSID3045198 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3045198 TK.Half.Life NA 24.77 hours 1compartment NA NA Human Human +DTXSID3045198 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human +DTXSID3045198 Css NA 8.15 mg/L 3compartmentss NA 95% Human Human +DTXSID3045198 Css NA 0.9397 mg/L PBTK NA 50% Human Human +DTXSID3045198 Css NA 5.34 mg/L PBTK NA 95% Human Human +DTXSID3045198 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045198 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045198 Vd NA 1.75 L/kg 1compartment NA NA Rat Human +DTXSID3045198 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3045198 TK.Half.Life NA 6.796 hours 1compartment NA NA Rat Human +DTXSID3045198 Css NA 0.169 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045198 Css NA 0.726 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045198 Css NA 0.1142 mg/L PBTK NA 50% Rat Human +DTXSID3045198 Css NA 0.4601 mg/L PBTK NA 95% Rat Human +DTXSID3045221 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045221 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045221 Vd NA 1.806 L/kg 1compartment NA NA Human Human DTXSID3045221 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045221 TK.Half.Life NA 3.877 hours 1compartment NA NA Human Human -DTXSID3045221 Css NA 0.04596 mg/L 3compartmentss NA 50% Human Human -DTXSID3045221 Css NA 0.4849 mg/L 3compartmentss NA 95% Human Human -DTXSID3045221 Css NA 0.06159 mg/L PBTK NA 50% Human Human -DTXSID3045221 Css NA 0.444 mg/L PBTK NA 95% Human Human -DTXSID3045221 Clint NA 9.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045221 Fup NA 0.5232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045221 Vd NA 3.977 L/kg 1compartment NA NA Rat Human +DTXSID3045221 TK.Half.Life NA 4.997 hours 1compartment NA NA Human Human +DTXSID3045221 Css NA 0.2162 mg/L 3compartmentss NA 50% Human Human +DTXSID3045221 Css NA 1.425 mg/L 3compartmentss NA 95% Human Human +DTXSID3045221 Css NA 0.1893 mg/L PBTK NA 50% Human Human +DTXSID3045221 Css NA 1.082 mg/L PBTK NA 95% Human Human +DTXSID3045221 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045221 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045221 Vd NA 1.803 L/kg 1compartment NA NA Rat Human DTXSID3045221 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045221 TK.Half.Life NA 2.241 hours 1compartment NA NA Rat Human -DTXSID3045221 Css NA 0.02243 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045221 Css NA 0.2125 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045221 Css NA 0.03077 mg/L PBTK NA 50% Rat Human -DTXSID3045221 Css NA 0.1756 mg/L PBTK NA 95% Rat Human -DTXSID3045223 Clint NA 18.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045223 Fup NA 0.1798 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045223 Vd NA 1.983 L/kg 1compartment NA NA Human Human +DTXSID3045221 TK.Half.Life NA 2.953 hours 1compartment NA NA Rat Human +DTXSID3045221 Css NA 0.02502 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045221 Css NA 0.1226 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045221 Css NA 0.02232 mg/L PBTK NA 50% Rat Human +DTXSID3045221 Css NA 0.0886 mg/L PBTK NA 95% Rat Human +DTXSID3045223 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045223 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045223 Vd NA 2.406 L/kg 1compartment NA NA Human Human DTXSID3045223 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045223 TK.Half.Life NA 2.667 hours 1compartment NA NA Human Human -DTXSID3045223 Css NA 0.07562 mg/L 3compartmentss NA 50% Human Human -DTXSID3045223 Css NA 0.6392 mg/L 3compartmentss NA 95% Human Human -DTXSID3045223 Css NA 0.07217 mg/L PBTK NA 50% Human Human -DTXSID3045223 Css NA 0.508 mg/L PBTK NA 95% Human Human -DTXSID3045223 Clint NA 18.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045223 Fup NA 0.1798 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045223 Vd NA 1.945 L/kg 1compartment NA NA Rat Human +DTXSID3045223 TK.Half.Life NA 2.232 hours 1compartment NA NA Human Human +DTXSID3045223 Css NA 0.03464 mg/L 3compartmentss NA 50% Human Human +DTXSID3045223 Css NA 0.3303 mg/L 3compartmentss NA 95% Human Human +DTXSID3045223 Css NA 0.03825 mg/L PBTK NA 50% Human Human +DTXSID3045223 Css NA 0.2872 mg/L PBTK NA 95% Human Human +DTXSID3045223 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045223 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045223 Vd NA 2.369 L/kg 1compartment NA NA Rat Human DTXSID3045223 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045223 TK.Half.Life NA 1.509 hours 1compartment NA NA Rat Human -DTXSID3045223 Css NA 0.04112 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045223 Css NA 0.2567 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045223 Css NA 0.03814 mg/L PBTK NA 50% Rat Human -DTXSID3045223 Css NA 0.1943 mg/L PBTK NA 95% Rat Human +DTXSID3045223 TK.Half.Life NA 1.209 hours 1compartment NA NA Rat Human +DTXSID3045223 Css NA 0.004266 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045223 Css NA 0.03014 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045223 Css NA 0.004822 mg/L PBTK NA 50% Rat Human +DTXSID3045223 Css NA 0.02658 mg/L PBTK NA 95% Rat Human DTXSID3045225 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3045225 Fup NA 0.5811 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045225 Vd NA 0.5984 L/kg 1compartment NA NA Human Human +DTXSID3045225 Vd NA 0.5426 L/kg 1compartment NA NA Human Human DTXSID3045225 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045225 TK.Half.Life NA 6.665 hours 1compartment NA NA Human Human -DTXSID3045225 Css NA 1.307 mg/L 3compartmentss NA 50% Human Human -DTXSID3045225 Css NA 8.802 mg/L 3compartmentss NA 95% Human Human -DTXSID3045225 Css NA 1.019 mg/L PBTK NA 50% Human Human -DTXSID3045225 Css NA 5.413 mg/L PBTK NA 95% Human Human +DTXSID3045225 TK.Half.Life NA 6.043 hours 1compartment NA NA Human Human +DTXSID3045225 Css NA 1.123 mg/L 3compartmentss NA 50% Human Human +DTXSID3045225 Css NA 7.645 mg/L 3compartmentss NA 95% Human Human +DTXSID3045225 Css NA 0.8602 mg/L PBTK NA 50% Human Human +DTXSID3045225 Css NA 4.762 mg/L PBTK NA 95% Human Human DTXSID3045225 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3045225 Fup NA 0.5811 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045225 Vd NA 0.6221 L/kg 1compartment NA NA Rat Human +DTXSID3045225 Vd NA 0.5727 L/kg 1compartment NA NA Rat Human DTXSID3045225 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045225 TK.Half.Life NA 2.36 hours 1compartment NA NA Rat Human -DTXSID3045225 Css NA 0.3409 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045225 Css NA 2.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045225 Css NA 0.255 mg/L PBTK NA 50% Rat Human -DTXSID3045225 Css NA 1.244 mg/L PBTK NA 95% Rat Human -DTXSID3045227 Clint NA 9.649 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045227 Fup NA 0.0675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045227 Vd NA 0.8167 L/kg 1compartment NA NA Human Human +DTXSID3045225 TK.Half.Life NA 2.173 hours 1compartment NA NA Rat Human +DTXSID3045225 Css NA 0.02149 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045225 Css NA 0.1771 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045225 Css NA 0.01572 mg/L PBTK NA 50% Rat Human +DTXSID3045225 Css NA 0.11 mg/L PBTK NA 95% Rat Human +DTXSID3045227 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045227 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045227 Vd NA 0.7328 L/kg 1compartment NA NA Human Human DTXSID3045227 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045227 TK.Half.Life NA 4.303 hours 1compartment NA NA Human Human -DTXSID3045227 Css NA 0.7578 mg/L 3compartmentss NA 50% Human Human -DTXSID3045227 Css NA 5.86 mg/L 3compartmentss NA 95% Human Human -DTXSID3045227 Css NA 0.506 mg/L PBTK NA 50% Human Human -DTXSID3045227 Css NA 3.628 mg/L PBTK NA 95% Human Human -DTXSID3045227 Clint NA 9.649 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045227 Fup NA 0.0675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045227 Vd NA 0.7866 L/kg 1compartment NA NA Rat Human +DTXSID3045227 TK.Half.Life NA 1.816 hours 1compartment NA NA Human Human +DTXSID3045227 Css NA 0.2108 mg/L 3compartmentss NA 50% Human Human +DTXSID3045227 Css NA 1.398 mg/L 3compartmentss NA 95% Human Human +DTXSID3045227 Css NA 0.1529 mg/L PBTK NA 50% Human Human +DTXSID3045227 Css NA 0.9306 mg/L PBTK NA 95% Human Human +DTXSID3045227 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045227 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045227 Vd NA 0.7197 L/kg 1compartment NA NA Rat Human DTXSID3045227 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045227 TK.Half.Life NA 2.612 hours 1compartment NA NA Rat Human -DTXSID3045227 Css NA 0.4139 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045227 Css NA 2.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045227 Css NA 0.2614 mg/L PBTK NA 50% Rat Human -DTXSID3045227 Css NA 1.373 mg/L PBTK NA 95% Rat Human -DTXSID3045271 Clint NA 28.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045271 Fup NA 0.1718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045271 Vd NA 4.679 L/kg 1compartment NA NA Human Human +DTXSID3045227 TK.Half.Life NA 1.021 hours 1compartment NA NA Rat Human +DTXSID3045227 Css NA 0.02518 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045227 Css NA 0.1173 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045227 Css NA 0.01815 mg/L PBTK NA 50% Rat Human +DTXSID3045227 Css NA 0.07491 mg/L PBTK NA 95% Rat Human +DTXSID3045271 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045271 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045271 Vd NA 4.436 L/kg 1compartment NA NA Human Human DTXSID3045271 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045271 TK.Half.Life NA 3.918 hours 1compartment NA NA Human Human -DTXSID3045271 Css NA 0.02991 mg/L 3compartmentss NA 50% Human Human -DTXSID3045271 Css NA 0.2239 mg/L 3compartmentss NA 95% Human Human -DTXSID3045271 Css NA 0.03706 mg/L PBTK NA 50% Human Human -DTXSID3045271 Css NA 0.231 mg/L PBTK NA 95% Human Human -DTXSID3045271 Clint NA 28.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045271 Fup NA 0.1718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045271 Vd NA 4.507 L/kg 1compartment NA NA Rat Human +DTXSID3045271 TK.Half.Life NA 10.47 hours 1compartment NA NA Human Human +DTXSID3045271 Css NA 0.1597 mg/L 3compartmentss NA 50% Human Human +DTXSID3045271 Css NA 1.32 mg/L 3compartmentss NA 95% Human Human +DTXSID3045271 Css NA 0.1827 mg/L PBTK NA 50% Human Human +DTXSID3045271 Css NA 1.194 mg/L PBTK NA 95% Human Human +DTXSID3045271 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045271 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045271 Vd NA 4.265 L/kg 1compartment NA NA Rat Human DTXSID3045271 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045271 TK.Half.Life NA 1.75 hours 1compartment NA NA Rat Human -DTXSID3045271 Css NA 0.01541 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045271 Css NA 0.1027 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045271 Css NA 0.01917 mg/L PBTK NA 50% Rat Human -DTXSID3045271 Css NA 0.09951 mg/L PBTK NA 95% Rat Human -DTXSID3045300 Clint NA 68.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045300 Fup NA 0.1061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045300 Vd NA 2.014 L/kg 1compartment NA NA Human Human +DTXSID3045271 TK.Half.Life NA 4.878 hours 1compartment NA NA Rat Human +DTXSID3045271 Css NA 0.01922 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045271 Css NA 0.1279 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045271 Css NA 0.02258 mg/L PBTK NA 50% Rat Human +DTXSID3045271 Css NA 0.1174 mg/L PBTK NA 95% Rat Human +DTXSID3045300 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045300 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045300 Vd NA 3.538 L/kg 1compartment NA NA Human Human DTXSID3045300 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045300 TK.Half.Life NA 2.157 hours 1compartment NA NA Human Human -DTXSID3045300 Css NA 0.05541 mg/L 3compartmentss NA 50% Human Human -DTXSID3045300 Css NA 0.5176 mg/L 3compartmentss NA 95% Human Human -DTXSID3045300 Css NA 0.04506 mg/L PBTK NA 50% Human Human -DTXSID3045300 Css NA 0.3646 mg/L PBTK NA 95% Human Human -DTXSID3045300 Clint NA 68.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045300 Fup NA 0.1061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045300 Vd NA 2.003 L/kg 1compartment NA NA Rat Human +DTXSID3045300 TK.Half.Life NA 8.191 hours 1compartment NA NA Human Human +DTXSID3045300 Css NA 0.141 mg/L 3compartmentss NA 50% Human Human +DTXSID3045300 Css NA 1.038 mg/L 3compartmentss NA 95% Human Human +DTXSID3045300 Css NA 0.1634 mg/L PBTK NA 50% Human Human +DTXSID3045300 Css NA 0.9453 mg/L PBTK NA 95% Human Human +DTXSID3045300 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045300 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045300 Vd NA 3.573 L/kg 1compartment NA NA Rat Human DTXSID3045300 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045300 TK.Half.Life NA 1.141 hours 1compartment NA NA Rat Human -DTXSID3045300 Css NA 0.03122 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045300 Css NA 0.251 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045300 Css NA 0.0241 mg/L PBTK NA 50% Rat Human -DTXSID3045300 Css NA 0.1653 mg/L PBTK NA 95% Rat Human +DTXSID3045300 TK.Half.Life NA 4.857 hours 1compartment NA NA Rat Human +DTXSID3045300 Css NA 0.01617 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045300 Css NA 0.09141 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045300 Css NA 0.01935 mg/L PBTK NA 50% Rat Human +DTXSID3045300 Css NA 0.08018 mg/L PBTK NA 95% Rat Human DTXSID3045304 Clint 8.956 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID3045304 Fup 0.16 NA NA https://doi.org/10.1124/dmd.117.077040 NA Human Human -DTXSID3045304 Vd NA 3.317 L/kg 1compartment NA NA Human Human +DTXSID3045304 Vd NA 2.792 L/kg 1compartment NA NA Human Human DTXSID3045304 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045304 TK.Half.Life NA 7.933 hours 1compartment NA NA Human Human -DTXSID3045304 Css NA 0.1822 mg/L 3compartmentss NA 50% Human Human -DTXSID3045304 Css NA 1.495 mg/L 3compartmentss NA 95% Human Human -DTXSID3045304 Css NA 0.1842 mg/L PBTK NA 50% Human Human -DTXSID3045304 Css NA 1.234 mg/L PBTK NA 95% Human Human +DTXSID3045304 TK.Half.Life NA 6.539 hours 1compartment NA NA Human Human +DTXSID3045304 Css NA 0.1728 mg/L 3compartmentss NA 50% Human Human +DTXSID3045304 Css NA 1.481 mg/L 3compartmentss NA 95% Human Human +DTXSID3045304 Css NA 0.1712 mg/L PBTK NA 50% Human Human +DTXSID3045304 Css NA 1.168 mg/L PBTK NA 95% Human Human DTXSID3045304 Clint 8.956 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID3045304 Fup 0.16 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human -DTXSID3045304 Vd NA 3.281 L/kg 1compartment NA NA Rat Human +DTXSID3045304 Vd NA 2.798 L/kg 1compartment NA NA Rat Human DTXSID3045304 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045304 TK.Half.Life NA 4.504 hours 1compartment NA NA Rat Human -DTXSID3045304 Css NA 0.09406 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045304 Css NA 0.5744 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045304 Css NA 0.09522 mg/L PBTK NA 50% Rat Human -DTXSID3045304 Css NA 0.4519 mg/L PBTK NA 95% Rat Human -DTXSID3045306 Clint NA 4.461 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045306 Fup NA 0.1719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045306 Vd NA 1.068 L/kg 1compartment NA NA Human Human -DTXSID3045306 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045306 TK.Half.Life NA 5.82 hours 1compartment NA NA Human Human -DTXSID3045306 Css NA 0.6106 mg/L 3compartmentss NA 50% Human Human -DTXSID3045306 Css NA 3.191 mg/L 3compartmentss NA 95% Human Human -DTXSID3045306 Css NA 0.4228 mg/L PBTK NA 50% Human Human -DTXSID3045306 Css NA 2.033 mg/L PBTK NA 95% Human Human -DTXSID3045306 Clint NA 4.461 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045306 Fup NA 0.1719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045306 Vd NA 0.8572 L/kg 1compartment NA NA Rat Human -DTXSID3045306 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045306 TK.Half.Life NA 2.526 hours 1compartment NA NA Rat Human -DTXSID3045306 Css NA 0.3004 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045306 Css NA 1.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045306 Css NA 0.1976 mg/L PBTK NA 50% Rat Human -DTXSID3045306 Css NA 0.7172 mg/L PBTK NA 95% Rat Human +DTXSID3045304 TK.Half.Life NA 3.977 hours 1compartment NA NA Rat Human +DTXSID3045304 Css NA 0.02067 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045304 Css NA 0.1421 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045304 Css NA 0.02103 mg/L PBTK NA 50% Rat Human +DTXSID3045304 Css NA 0.1074 mg/L PBTK NA 95% Rat Human +DTXSID3045306 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045306 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045306 Vd NA 1.377 L/kg 1compartment NA NA Human Human +DTXSID3045306 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3045306 TK.Half.Life NA 39.29 hours 1compartment NA NA Human Human +DTXSID3045306 Css NA 3.066 mg/L 3compartmentss NA 50% Human Human +DTXSID3045306 Css NA 11.27 mg/L 3compartmentss NA 95% Human Human +DTXSID3045306 Css NA 2.282 mg/L PBTK NA 50% Human Human +DTXSID3045306 Css NA 7.356 mg/L PBTK NA 95% Human Human +DTXSID3045306 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045306 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045306 Vd NA 1.111 L/kg 1compartment NA NA Rat Human +DTXSID3045306 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3045306 TK.Half.Life NA 9.192 hours 1compartment NA NA Rat Human +DTXSID3045306 Css NA 0.1942 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045306 Css NA 0.6102 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045306 Css NA 0.1434 mg/L PBTK NA 50% Rat Human +DTXSID3045306 Css NA 0.3813 mg/L PBTK NA 95% Rat Human DTXSID3045350 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3045350 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3045350 Vd NA 0.7001 L/kg 1compartment NA NA Human Human +DTXSID3045350 Vd NA 0.7385 L/kg 1compartment NA NA Human Human DTXSID3045350 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045350 TK.Half.Life NA 4.671 hours 1compartment NA NA Human Human -DTXSID3045350 Css NA 0.9024 mg/L 3compartmentss NA 50% Human Human -DTXSID3045350 Css NA 5.135 mg/L 3compartmentss NA 95% Human Human -DTXSID3045350 Css NA 0.7296 mg/L PBTK NA 50% Human Human -DTXSID3045350 Css NA 3.396 mg/L PBTK NA 95% Human Human +DTXSID3045350 TK.Half.Life NA 4.926 hours 1compartment NA NA Human Human +DTXSID3045350 Css NA 0.8429 mg/L 3compartmentss NA 50% Human Human +DTXSID3045350 Css NA 4.704 mg/L 3compartmentss NA 95% Human Human +DTXSID3045350 Css NA 0.6987 mg/L PBTK NA 50% Human Human +DTXSID3045350 Css NA 3.097 mg/L PBTK NA 95% Human Human DTXSID3045350 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3045350 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3045350 Vd NA 0.7469 L/kg 1compartment NA NA Rat Human +DTXSID3045350 Vd NA 0.7793 L/kg 1compartment NA NA Rat Human DTXSID3045350 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045350 TK.Half.Life NA 1.698 hours 1compartment NA NA Rat Human -DTXSID3045350 Css NA 0.228 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045350 Css NA 1.203 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045350 Css NA 0.1816 mg/L PBTK NA 50% Rat Human -DTXSID3045350 Css NA 0.727 mg/L PBTK NA 95% Rat Human -DTXSID3045352 Clint NA 1665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045352 Fup NA 0.4165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045352 Vd NA 0.4194 L/kg 1compartment NA NA Human Human -DTXSID3045352 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045352 TK.Half.Life NA 0.3215 hours 1compartment NA NA Human Human -DTXSID3045352 Css NA 0.0003272 mg/L 3compartmentss NA 50% Human Human -DTXSID3045352 Css NA 0.002732 mg/L 3compartmentss NA 95% Human Human -DTXSID3045352 Css NA 0.0002295 mg/L PBTK NA 50% Human Human -DTXSID3045352 Css NA 0.001761 mg/L PBTK NA 95% Human Human -DTXSID3045352 Clint NA 1665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045352 Fup NA 0.4165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045352 Vd NA 0.4487 L/kg 1compartment NA NA Rat Human -DTXSID3045352 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045352 TK.Half.Life NA 0.1491 hours 1compartment NA NA Rat Human -DTXSID3045352 Css NA 0.0001791 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045352 Css NA 0.001319 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045352 Css NA 0.0001207 mg/L PBTK NA 50% Rat Human -DTXSID3045352 Css NA 0.0008156 mg/L PBTK NA 95% Rat Human -DTXSID3045354 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045354 Fup NA 0.2411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045354 Vd NA 2.556 L/kg 1compartment NA NA Human Human -DTXSID3045354 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID3045354 TK.Half.Life NA 77.67 hours 1compartment NA NA Human Human -DTXSID3045354 Css NA 2.637 mg/L 3compartmentss NA 50% Human Human -DTXSID3045354 Css NA 11 mg/L 3compartmentss NA 95% Human Human -DTXSID3045354 Css NA 2.479 mg/L PBTK NA 50% Human Human -DTXSID3045354 Css NA 8.061 mg/L PBTK NA 95% Human Human -DTXSID3045354 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045354 Fup NA 0.2411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045354 Vd NA 2.468 L/kg 1compartment NA NA Rat Human -DTXSID3045354 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3045354 TK.Half.Life NA 23.28 hours 1compartment NA NA Rat Human -DTXSID3045354 Css NA 0.7105 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045354 Css NA 2.523 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045354 Css NA 0.6519 mg/L PBTK NA 50% Rat Human -DTXSID3045354 Css NA 1.723 mg/L PBTK NA 95% Rat Human -DTXSID3045356 Clint NA 15.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045356 Fup NA 0.0907 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045356 Vd NA 1.9 L/kg 1compartment NA NA Human Human +DTXSID3045350 TK.Half.Life NA 1.772 hours 1compartment NA NA Rat Human +DTXSID3045350 Css NA 0.04686 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045350 Css NA 0.2503 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045350 Css NA 0.03944 mg/L PBTK NA 50% Rat Human +DTXSID3045350 Css NA 0.1584 mg/L PBTK NA 95% Rat Human +DTXSID3045356 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045356 Fup 0.05 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045356 Vd NA 1.056 L/kg 1compartment NA NA Human Human DTXSID3045356 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045356 TK.Half.Life NA 5.424 hours 1compartment NA NA Human Human -DTXSID3045356 Css NA 0.306 mg/L 3compartmentss NA 50% Human Human -DTXSID3045356 Css NA 2.638 mg/L 3compartmentss NA 95% Human Human -DTXSID3045356 Css NA 0.2376 mg/L PBTK NA 50% Human Human -DTXSID3045356 Css NA 1.77 mg/L PBTK NA 95% Human Human -DTXSID3045356 Clint NA 15.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045356 Fup NA 0.0907 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045356 Vd NA 1.871 L/kg 1compartment NA NA Rat Human +DTXSID3045356 TK.Half.Life NA 4.018 hours 1compartment NA NA Human Human +DTXSID3045356 Css NA 0.4859 mg/L 3compartmentss NA 50% Human Human +DTXSID3045356 Css NA 4.423 mg/L 3compartmentss NA 95% Human Human +DTXSID3045356 Css NA 0.3249 mg/L PBTK NA 50% Human Human +DTXSID3045356 Css NA 2.774 mg/L PBTK NA 95% Human Human +DTXSID3045356 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045356 Fup 0.05 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045356 Vd NA 1.034 L/kg 1compartment NA NA Rat Human DTXSID3045356 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045356 TK.Half.Life NA 3.237 hours 1compartment NA NA Rat Human -DTXSID3045356 Css NA 0.1665 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045356 Css NA 1.126 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045356 Css NA 0.1232 mg/L PBTK NA 50% Rat Human -DTXSID3045356 Css NA 0.7122 mg/L PBTK NA 95% Rat Human -DTXSID3045433 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045433 Fup NA 0.1281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045433 Vd NA 0.3645 L/kg 1compartment NA NA Human Human -DTXSID3045433 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045433 TK.Half.Life NA 1.326 hours 1compartment NA NA Human Human -DTXSID3045433 Css NA 0.471 mg/L 3compartmentss NA 50% Human Human -DTXSID3045433 Css NA 3.46 mg/L 3compartmentss NA 95% Human Human -DTXSID3045433 Css NA 0.294 mg/L PBTK NA 50% Human Human -DTXSID3045433 Css NA 2.067 mg/L PBTK NA 95% Human Human -DTXSID3045433 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045433 Fup NA 0.1281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045433 Vd NA 0.3405 L/kg 1compartment NA NA Rat Human +DTXSID3045356 TK.Half.Life NA 2.465 hours 1compartment NA NA Rat Human +DTXSID3045356 Css NA 0.06374 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045356 Css NA 0.4479 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045356 Css NA 0.04136 mg/L PBTK NA 50% Rat Human +DTXSID3045356 Css NA 0.2675 mg/L PBTK NA 95% Rat Human +DTXSID3045433 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045433 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045433 Vd NA 0.3422 L/kg 1compartment NA NA Human Human +DTXSID3045433 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3045433 TK.Half.Life NA 12.46 hours 1compartment NA NA Human Human +DTXSID3045433 Css NA 2.444 mg/L 3compartmentss NA 50% Human Human +DTXSID3045433 Css NA 9.547 mg/L 3compartmentss NA 95% Human Human +DTXSID3045433 Css NA 1.566 mg/L PBTK NA 50% Human Human +DTXSID3045433 Css NA 5.74 mg/L PBTK NA 95% Human Human +DTXSID3045433 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045433 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045433 Vd NA 0.3347 L/kg 1compartment NA NA Rat Human DTXSID3045433 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045433 TK.Half.Life NA 0.744 hours 1compartment NA NA Rat Human -DTXSID3045433 Css NA 0.2508 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045433 Css NA 1.343 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045433 Css NA 0.1473 mg/L PBTK NA 50% Rat Human -DTXSID3045433 Css NA 0.7571 mg/L PBTK NA 95% Rat Human -DTXSID3045435 Clint NA 43.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045435 Fup NA 0.0278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045435 Vd NA 2.775 L/kg 1compartment NA NA Human Human -DTXSID3045435 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3045435 TK.Half.Life NA 19.03 hours 1compartment NA NA Human Human -DTXSID3045435 Css NA 0.8605 mg/L 3compartmentss NA 50% Human Human -DTXSID3045435 Css NA 6.195 mg/L 3compartmentss NA 95% Human Human -DTXSID3045435 Css NA 0.582 mg/L PBTK NA 50% Human Human -DTXSID3045435 Css NA 3.988 mg/L PBTK NA 95% Human Human -DTXSID3045435 Clint NA 43.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045435 Fup NA 0.0278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045435 Vd NA 2.076 L/kg 1compartment NA NA Rat Human -DTXSID3045435 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045435 TK.Half.Life NA 4.009 hours 1compartment NA NA Rat Human -DTXSID3045435 Css NA 0.4784 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045435 Css NA 2.788 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045435 Css NA 0.3077 mg/L PBTK NA 50% Rat Human -DTXSID3045435 Css NA 1.733 mg/L PBTK NA 95% Rat Human -DTXSID3045437 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045437 Fup NA 0.9664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045437 Vd NA 3.639 L/kg 1compartment NA NA Human Human -DTXSID3045437 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3045437 TK.Half.Life NA 24.47 hours 1compartment NA NA Human Human -DTXSID3045437 Css NA 0.5864 mg/L 3compartmentss NA 50% Human Human -DTXSID3045437 Css NA 4.29 mg/L 3compartmentss NA 95% Human Human -DTXSID3045437 Css NA 0.7378 mg/L PBTK NA 50% Human Human -DTXSID3045437 Css NA 3.266 mg/L PBTK NA 95% Human Human -DTXSID3045437 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045437 Fup NA 0.9664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045437 Vd NA 3.718 L/kg 1compartment NA NA Rat Human +DTXSID3045433 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human +DTXSID3045433 Css NA 0.01346 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045433 Css NA 0.0509 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045433 Css NA 0.008147 mg/L PBTK NA 50% Rat Human +DTXSID3045433 Css NA 0.02922 mg/L PBTK NA 95% Rat Human +DTXSID3045435 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045435 Fup 0.0302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045435 Vd NA 2.92 L/kg 1compartment NA NA Human Human +DTXSID3045435 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID3045435 TK.Half.Life NA 43.68 hours 1compartment NA NA Human Human +DTXSID3045435 Css NA 1.892 mg/L 3compartmentss NA 50% Human Human +DTXSID3045435 Css NA 12.68 mg/L 3compartmentss NA 95% Human Human +DTXSID3045435 Css NA 1.288 mg/L PBTK NA 50% Human Human +DTXSID3045435 Css NA 8.311 mg/L PBTK NA 95% Human Human +DTXSID3045435 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045435 Fup 0.0302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045435 Vd NA 2.187 L/kg 1compartment NA NA Rat Human +DTXSID3045435 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3045435 TK.Half.Life NA 7.699 hours 1compartment NA NA Rat Human +DTXSID3045435 Css NA 0.2424 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045435 Css NA 1.334 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045435 Css NA 0.1638 mg/L PBTK NA 50% Rat Human +DTXSID3045435 Css NA 0.8812 mg/L PBTK NA 95% Rat Human +DTXSID3045437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045437 Fup 0.78 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045437 Vd NA 1.732 L/kg 1compartment NA NA Human Human +DTXSID3045437 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3045437 TK.Half.Life NA 14.37 hours 1compartment NA NA Human Human +DTXSID3045437 Css NA 0.7266 mg/L 3compartmentss NA 50% Human Human +DTXSID3045437 Css NA 5.353 mg/L 3compartmentss NA 95% Human Human +DTXSID3045437 Css NA 0.7094 mg/L PBTK NA 50% Human Human +DTXSID3045437 Css NA 3.629 mg/L PBTK NA 95% Human Human +DTXSID3045437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045437 Fup 0.78 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045437 Vd NA 1.766 L/kg 1compartment NA NA Rat Human DTXSID3045437 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045437 TK.Half.Life NA 8.491 hours 1compartment NA NA Rat Human -DTXSID3045437 Css NA 0.144 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045437 Css NA 1.007 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045437 Css NA 0.1831 mg/L PBTK NA 50% Rat Human -DTXSID3045437 Css NA 0.7286 mg/L PBTK NA 95% Rat Human -DTXSID3045439 Clint NA 9.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045439 Fup NA 0.433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045439 Vd NA 2.984 L/kg 1compartment NA NA Human Human +DTXSID3045437 TK.Half.Life NA 4.994 hours 1compartment NA NA Rat Human +DTXSID3045437 Css NA 0.0185 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045437 Css NA 0.1459 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045437 Css NA 0.0178 mg/L PBTK NA 50% Rat Human +DTXSID3045437 Css NA 0.102 mg/L PBTK NA 95% Rat Human +DTXSID3045439 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045439 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045439 Vd NA 2.479 L/kg 1compartment NA NA Human Human DTXSID3045439 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045439 TK.Half.Life NA 6.749 hours 1compartment NA NA Human Human -DTXSID3045439 Css NA 0.1762 mg/L 3compartmentss NA 50% Human Human -DTXSID3045439 Css NA 1.044 mg/L 3compartmentss NA 95% Human Human -DTXSID3045439 Css NA 0.1556 mg/L PBTK NA 50% Human Human -DTXSID3045439 Css NA 0.8269 mg/L PBTK NA 95% Human Human -DTXSID3045439 Clint NA 9.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045439 Fup NA 0.433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045439 Vd NA 2.535 L/kg 1compartment NA NA Rat Human +DTXSID3045439 TK.Half.Life NA 11.04 hours 1compartment NA NA Human Human +DTXSID3045439 Css NA 0.418 mg/L 3compartmentss NA 50% Human Human +DTXSID3045439 Css NA 2.346 mg/L 3compartmentss NA 95% Human Human +DTXSID3045439 Css NA 0.3295 mg/L PBTK NA 50% Human Human +DTXSID3045439 Css NA 1.722 mg/L PBTK NA 95% Human Human +DTXSID3045439 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045439 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045439 Vd NA 2.065 L/kg 1compartment NA NA Rat Human DTXSID3045439 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045439 TK.Half.Life NA 2.248 hours 1compartment NA NA Rat Human -DTXSID3045439 Css NA 0.08976 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045439 Css NA 0.4232 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045439 Css NA 0.07786 mg/L PBTK NA 50% Rat Human -DTXSID3045439 Css NA 0.3197 mg/L PBTK NA 95% Rat Human -DTXSID3045485 Clint NA 14.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045485 Fup NA 0.2774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045485 Vd NA 4.386 L/kg 1compartment NA NA Human Human +DTXSID3045439 TK.Half.Life NA 3.918 hours 1compartment NA NA Rat Human +DTXSID3045439 Css NA 0.04919 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045439 Css NA 0.1959 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045439 Css NA 0.03926 mg/L PBTK NA 50% Rat Human +DTXSID3045439 Css NA 0.1434 mg/L PBTK NA 95% Rat Human +DTXSID3045485 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045485 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045485 Vd NA 3.956 L/kg 1compartment NA NA Human Human DTXSID3045485 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045485 TK.Half.Life NA 6.15 hours 1compartment NA NA Human Human -DTXSID3045485 Css NA 0.07357 mg/L 3compartmentss NA 50% Human Human -DTXSID3045485 Css NA 0.5468 mg/L 3compartmentss NA 95% Human Human -DTXSID3045485 Css NA 0.08728 mg/L PBTK NA 50% Human Human -DTXSID3045485 Css NA 0.5245 mg/L PBTK NA 95% Human Human -DTXSID3045485 Clint NA 14.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045485 Fup NA 0.2774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045485 Vd NA 4.218 L/kg 1compartment NA NA Rat Human +DTXSID3045485 TK.Half.Life NA 3.689 hours 1compartment NA NA Human Human +DTXSID3045485 Css NA 0.03599 mg/L 3compartmentss NA 50% Human Human +DTXSID3045485 Css NA 0.3194 mg/L 3compartmentss NA 95% Human Human +DTXSID3045485 Css NA 0.04348 mg/L PBTK NA 50% Human Human +DTXSID3045485 Css NA 0.3068 mg/L PBTK NA 95% Human Human +DTXSID3045485 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045485 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045485 Vd NA 3.944 L/kg 1compartment NA NA Rat Human DTXSID3045485 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045485 TK.Half.Life NA 2.809 hours 1compartment NA NA Rat Human -DTXSID3045485 Css NA 0.0382 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045485 Css NA 0.218 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045485 Css NA 0.04546 mg/L PBTK NA 50% Rat Human -DTXSID3045485 Css NA 0.2069 mg/L PBTK NA 95% Rat Human -DTXSID3045514 Clint NA 34.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045514 Fup NA 0.2273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045514 Vd NA 0.6615 L/kg 1compartment NA NA Human Human +DTXSID3045485 TK.Half.Life NA 1.935 hours 1compartment NA NA Rat Human +DTXSID3045485 Css NA 0.004301 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045485 Css NA 0.02872 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045485 Css NA 0.005422 mg/L PBTK NA 50% Rat Human +DTXSID3045485 Css NA 0.02823 mg/L PBTK NA 95% Rat Human +DTXSID3045514 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045514 Fup 0.259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045514 Vd NA 0.7624 L/kg 1compartment NA NA Human Human DTXSID3045514 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045514 TK.Half.Life NA 0.8337 hours 1compartment NA NA Human Human -DTXSID3045514 Css NA 0.06194 mg/L 3compartmentss NA 50% Human Human -DTXSID3045514 Css NA 0.4585 mg/L 3compartmentss NA 95% Human Human -DTXSID3045514 Css NA 0.04282 mg/L PBTK NA 50% Human Human -DTXSID3045514 Css NA 0.2982 mg/L PBTK NA 95% Human Human -DTXSID3045514 Clint NA 34.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045514 Fup NA 0.2273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045514 Vd NA 0.5974 L/kg 1compartment NA NA Rat Human +DTXSID3045514 TK.Half.Life NA 2.193 hours 1compartment NA NA Human Human +DTXSID3045514 Css NA 0.2614 mg/L 3compartmentss NA 50% Human Human +DTXSID3045514 Css NA 1.61 mg/L 3compartmentss NA 95% Human Human +DTXSID3045514 Css NA 0.1853 mg/L PBTK NA 50% Human Human +DTXSID3045514 Css NA 1.043 mg/L PBTK NA 95% Human Human +DTXSID3045514 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045514 Fup 0.259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045514 Vd NA 0.679 L/kg 1compartment NA NA Rat Human DTXSID3045514 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045514 TK.Half.Life NA 0.3909 hours 1compartment NA NA Rat Human -DTXSID3045514 Css NA 0.03389 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045514 Css NA 0.1957 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045514 Css NA 0.02239 mg/L PBTK NA 50% Rat Human -DTXSID3045514 Css NA 0.1217 mg/L PBTK NA 95% Rat Human -DTXSID3045560 Clint NA 8.656 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045560 Fup NA 0.0766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045560 Vd NA 3.077 L/kg 1compartment NA NA Human Human -DTXSID3045560 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID3045560 TK.Half.Life NA 117.2 hours 1compartment NA NA Human Human -DTXSID3045560 Css NA 4.694 mg/L 3compartmentss NA 50% Human Human -DTXSID3045560 Css NA 28.81 mg/L 3compartmentss NA 95% Human Human -DTXSID3045560 Css NA 3.277 mg/L PBTK NA 50% Human Human -DTXSID3045560 Css NA 19.36 mg/L PBTK NA 95% Human Human -DTXSID3045560 Clint NA 8.656 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045560 Fup NA 0.0766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045560 Vd NA 2.309 L/kg 1compartment NA NA Rat Human -DTXSID3045560 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID3045560 TK.Half.Life NA 16.5 hours 1compartment NA NA Rat Human -DTXSID3045560 Css NA 2.623 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045560 Css NA 12.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045560 Css NA 1.745 mg/L PBTK NA 50% Rat Human -DTXSID3045560 Css NA 8.285 mg/L PBTK NA 95% Rat Human -DTXSID3045562 Clint NA 47.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045562 Fup NA 0.0544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045562 Vd NA 3.393 L/kg 1compartment NA NA Human Human +DTXSID3045514 TK.Half.Life NA 1.107 hours 1compartment NA NA Rat Human +DTXSID3045514 Css NA 0.03114 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045514 Css NA 0.1386 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045514 Css NA 0.022 mg/L PBTK NA 50% Rat Human +DTXSID3045514 Css NA 0.08786 mg/L PBTK NA 95% Rat Human +DTXSID3045560 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045560 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045560 Vd NA 0.9682 L/kg 1compartment NA NA Human Human +DTXSID3045560 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3045560 TK.Half.Life NA 1.259 hours 1compartment NA NA Human Human +DTXSID3045560 Css NA 0.06747 mg/L 3compartmentss NA 50% Human Human +DTXSID3045560 Css NA 0.5208 mg/L 3compartmentss NA 95% Human Human +DTXSID3045560 Css NA 0.05023 mg/L PBTK NA 50% Human Human +DTXSID3045560 Css NA 0.3542 mg/L PBTK NA 95% Human Human +DTXSID3045560 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045560 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045560 Vd NA 0.8876 L/kg 1compartment NA NA Rat Human +DTXSID3045560 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3045560 TK.Half.Life NA 0.6091 hours 1compartment NA NA Rat Human +DTXSID3045560 Css NA 0.008462 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045560 Css NA 0.04957 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045560 Css NA 0.006249 mg/L PBTK NA 50% Rat Human +DTXSID3045560 Css NA 0.03316 mg/L PBTK NA 95% Rat Human +DTXSID3045562 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045562 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045562 Vd NA 0.6999 L/kg 1compartment NA NA Human Human DTXSID3045562 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045562 TK.Half.Life NA 4.119 hours 1compartment NA NA Human Human -DTXSID3045562 Css NA 0.06308 mg/L 3compartmentss NA 50% Human Human -DTXSID3045562 Css NA 0.4452 mg/L 3compartmentss NA 95% Human Human -DTXSID3045562 Css NA 0.04992 mg/L PBTK NA 50% Human Human -DTXSID3045562 Css NA 0.3295 mg/L PBTK NA 95% Human Human -DTXSID3045562 Clint NA 47.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045562 Fup NA 0.0544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045562 Vd NA 2.804 L/kg 1compartment NA NA Rat Human +DTXSID3045562 TK.Half.Life NA 1.551 hours 1compartment NA NA Human Human +DTXSID3045562 Css NA 0.2137 mg/L 3compartmentss NA 50% Human Human +DTXSID3045562 Css NA 1.811 mg/L 3compartmentss NA 95% Human Human +DTXSID3045562 Css NA 0.1413 mg/L PBTK NA 50% Human Human +DTXSID3045562 Css NA 1.11 mg/L PBTK NA 95% Human Human +DTXSID3045562 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045562 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045562 Vd NA 0.6942 L/kg 1compartment NA NA Rat Human DTXSID3045562 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045562 TK.Half.Life NA 1.282 hours 1compartment NA NA Rat Human -DTXSID3045562 Css NA 0.03496 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045562 Css NA 0.2052 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045562 Css NA 0.02681 mg/L PBTK NA 50% Rat Human -DTXSID3045562 Css NA 0.1473 mg/L PBTK NA 95% Rat Human -DTXSID3045566 Clint NA 13.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045566 Fup NA 0.1074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045566 Vd NA 3.136 L/kg 1compartment NA NA Human Human -DTXSID3045566 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3045566 TK.Half.Life NA 42.97 hours 1compartment NA NA Human Human -DTXSID3045566 Css NA 1.602 mg/L 3compartmentss NA 50% Human Human -DTXSID3045566 Css NA 9.974 mg/L 3compartmentss NA 95% Human Human -DTXSID3045566 Css NA 1.151 mg/L PBTK NA 50% Human Human -DTXSID3045566 Css NA 6.964 mg/L PBTK NA 95% Human Human -DTXSID3045566 Clint NA 13.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045566 Fup NA 0.1074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045566 Vd NA 2.405 L/kg 1compartment NA NA Rat Human -DTXSID3045566 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3045566 TK.Half.Life NA 7.198 hours 1compartment NA NA Rat Human -DTXSID3045566 Css NA 0.882 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045566 Css NA 4.263 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045566 Css NA 0.6086 mg/L PBTK NA 50% Rat Human -DTXSID3045566 Css NA 2.786 mg/L PBTK NA 95% Rat Human -DTXSID3045568 Clint NA 2.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045568 Fup NA 0.0323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045568 Vd NA 2.841 L/kg 1compartment NA NA Human Human -DTXSID3045568 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID3045568 TK.Half.Life NA 83.83 hours 1compartment NA NA Human Human -DTXSID3045568 Css NA 4.12 mg/L 3compartmentss NA 50% Human Human -DTXSID3045568 Css NA 26.45 mg/L 3compartmentss NA 95% Human Human -DTXSID3045568 Css NA 2.932 mg/L PBTK NA 50% Human Human -DTXSID3045568 Css NA 17.64 mg/L PBTK NA 95% Human Human -DTXSID3045568 Clint NA 2.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045568 Fup NA 0.0323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045568 Vd NA 2.252 L/kg 1compartment NA NA Rat Human -DTXSID3045568 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID3045568 TK.Half.Life NA 21.42 hours 1compartment NA NA Rat Human -DTXSID3045568 Css NA 2.18 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045568 Css NA 10.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045568 Css NA 1.47 mg/L PBTK NA 50% Rat Human -DTXSID3045568 Css NA 6.642 mg/L PBTK NA 95% Rat Human -DTXSID3045645 Clint NA 5.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045645 Fup NA 0.1144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045645 Vd NA 0.8286 L/kg 1compartment NA NA Human Human +DTXSID3045562 TK.Half.Life NA 0.9016 hours 1compartment NA NA Rat Human +DTXSID3045562 Css NA 0.0278 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045562 Css NA 0.1784 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045562 Css NA 0.01792 mg/L PBTK NA 50% Rat Human +DTXSID3045562 Css NA 0.1058 mg/L PBTK NA 95% Rat Human +DTXSID3045566 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045566 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045566 Vd NA 2.376 L/kg 1compartment NA NA Human Human +DTXSID3045566 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3045566 TK.Half.Life NA 4.976 hours 1compartment NA NA Human Human +DTXSID3045566 Css NA 0.1581 mg/L 3compartmentss NA 50% Human Human +DTXSID3045566 Css NA 1.037 mg/L 3compartmentss NA 95% Human Human +DTXSID3045566 Css NA 0.1162 mg/L PBTK NA 50% Human Human +DTXSID3045566 Css NA 0.7292 mg/L PBTK NA 95% Human Human +DTXSID3045566 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045566 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045566 Vd NA 1.825 L/kg 1compartment NA NA Rat Human +DTXSID3045566 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3045566 TK.Half.Life NA 1.493 hours 1compartment NA NA Rat Human +DTXSID3045566 Css NA 0.01985 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045566 Css NA 0.09659 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045566 Css NA 0.01464 mg/L PBTK NA 50% Rat Human +DTXSID3045566 Css NA 0.06768 mg/L PBTK NA 95% Rat Human +DTXSID3045568 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045568 Fup 0.0898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045568 Vd NA 2.916 L/kg 1compartment NA NA Human Human +DTXSID3045568 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3045568 TK.Half.Life NA 24.18 hours 1compartment NA NA Human Human +DTXSID3045568 Css NA 0.9521 mg/L 3compartmentss NA 50% Human Human +DTXSID3045568 Css NA 6.059 mg/L 3compartmentss NA 95% Human Human +DTXSID3045568 Css NA 0.6618 mg/L PBTK NA 50% Human Human +DTXSID3045568 Css NA 4.13 mg/L PBTK NA 95% Human Human +DTXSID3045568 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045568 Fup 0.0898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045568 Vd NA 2.19 L/kg 1compartment NA NA Rat Human +DTXSID3045568 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3045568 TK.Half.Life NA 4.475 hours 1compartment NA NA Rat Human +DTXSID3045568 Css NA 0.1221 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045568 Css NA 0.6445 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045568 Css NA 0.08411 mg/L PBTK NA 50% Rat Human +DTXSID3045568 Css NA 0.4392 mg/L PBTK NA 95% Rat Human +DTXSID3045645 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045645 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045645 Vd NA 0.9467 L/kg 1compartment NA NA Human Human DTXSID3045645 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045645 TK.Half.Life NA 5.255 hours 1compartment NA NA Human Human -DTXSID3045645 Css NA 0.8918 mg/L 3compartmentss NA 50% Human Human -DTXSID3045645 Css NA 5.869 mg/L 3compartmentss NA 95% Human Human -DTXSID3045645 Css NA 0.5798 mg/L PBTK NA 50% Human Human -DTXSID3045645 Css NA 3.513 mg/L PBTK NA 95% Human Human -DTXSID3045645 Clint NA 5.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045645 Fup NA 0.1144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045645 Vd NA 0.6719 L/kg 1compartment NA NA Rat Human +DTXSID3045645 TK.Half.Life NA 1.912 hours 1compartment NA NA Human Human +DTXSID3045645 Css NA 0.1748 mg/L 3compartmentss NA 50% Human Human +DTXSID3045645 Css NA 1.381 mg/L 3compartmentss NA 95% Human Human +DTXSID3045645 Css NA 0.1165 mg/L PBTK NA 50% Human Human +DTXSID3045645 Css NA 0.8702 mg/L PBTK NA 95% Human Human +DTXSID3045645 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045645 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045645 Vd NA 0.769 L/kg 1compartment NA NA Rat Human DTXSID3045645 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045645 TK.Half.Life NA 2.45 hours 1compartment NA NA Rat Human -DTXSID3045645 Css NA 0.465 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045645 Css NA 2.271 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045645 Css NA 0.2842 mg/L PBTK NA 50% Rat Human -DTXSID3045645 Css NA 1.286 mg/L PBTK NA 95% Rat Human -DTXSID3045647 Clint NA 8.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045647 Fup NA 0.1074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045647 Vd NA 0.9611 L/kg 1compartment NA NA Human Human +DTXSID3045645 TK.Half.Life NA 0.8494 hours 1compartment NA NA Rat Human +DTXSID3045645 Css NA 0.02271 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045645 Css NA 0.1383 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045645 Css NA 0.0149 mg/L PBTK NA 50% Rat Human +DTXSID3045645 Css NA 0.08509 mg/L PBTK NA 95% Rat Human +DTXSID3045647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045647 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045647 Vd NA 1.188 L/kg 1compartment NA NA Human Human DTXSID3045647 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045647 TK.Half.Life NA 4.545 hours 1compartment NA NA Human Human -DTXSID3045647 Css NA 0.6364 mg/L 3compartmentss NA 50% Human Human -DTXSID3045647 Css NA 4.482 mg/L 3compartmentss NA 95% Human Human -DTXSID3045647 Css NA 0.4134 mg/L PBTK NA 50% Human Human -DTXSID3045647 Css NA 2.767 mg/L PBTK NA 95% Human Human -DTXSID3045647 Clint NA 8.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045647 Fup NA 0.1074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045647 Vd NA 0.7579 L/kg 1compartment NA NA Rat Human +DTXSID3045647 TK.Half.Life NA 2.321 hours 1compartment NA NA Human Human +DTXSID3045647 Css NA 0.155 mg/L 3compartmentss NA 50% Human Human +DTXSID3045647 Css NA 1.158 mg/L 3compartmentss NA 95% Human Human +DTXSID3045647 Css NA 0.1061 mg/L PBTK NA 50% Human Human +DTXSID3045647 Css NA 0.7527 mg/L PBTK NA 95% Human Human +DTXSID3045647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045647 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045647 Vd NA 0.9396 L/kg 1compartment NA NA Rat Human DTXSID3045647 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045647 TK.Half.Life NA 2.037 hours 1compartment NA NA Rat Human -DTXSID3045647 Css NA 0.3432 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045647 Css NA 1.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045647 Css NA 0.2094 mg/L PBTK NA 50% Rat Human -DTXSID3045647 Css NA 1.06 mg/L PBTK NA 95% Rat Human +DTXSID3045647 TK.Half.Life NA 0.9643 hours 1compartment NA NA Rat Human +DTXSID3045647 Css NA 0.01996 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045647 Css NA 0.1163 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045647 Css NA 0.01342 mg/L PBTK NA 50% Rat Human +DTXSID3045647 Css NA 0.07341 mg/L PBTK NA 95% Rat Human DTXSID3045649 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3045649 Fup NA 0.9705 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3045649 Vd NA 0.6728 L/kg 1compartment NA NA Human Human DTXSID3045649 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3045649 TK.Half.Life NA 4.483 hours 1compartment NA NA Human Human -DTXSID3045649 Css NA 0.9003 mg/L 3compartmentss NA 50% Human Human -DTXSID3045649 Css NA 5.253 mg/L 3compartmentss NA 95% Human Human -DTXSID3045649 Css NA 0.7304 mg/L PBTK NA 50% Human Human -DTXSID3045649 Css NA 3.391 mg/L PBTK NA 95% Human Human +DTXSID3045649 Css NA 0.768 mg/L 3compartmentss NA 50% Human Human +DTXSID3045649 Css NA 4.374 mg/L 3compartmentss NA 95% Human Human +DTXSID3045649 Css NA 0.6267 mg/L PBTK NA 50% Human Human +DTXSID3045649 Css NA 2.849 mg/L PBTK NA 95% Human Human DTXSID3045649 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3045649 Fup NA 0.9705 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3045649 Vd NA 0.7243 L/kg 1compartment NA NA Rat Human DTXSID3045649 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3045649 TK.Half.Life NA 1.646 hours 1compartment NA NA Rat Human -DTXSID3045649 Css NA 0.2307 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045649 Css NA 1.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045649 Css NA 0.182 mg/L PBTK NA 50% Rat Human -DTXSID3045649 Css NA 0.7451 mg/L PBTK NA 95% Rat Human -DTXSID3045691 Clint NA 2.821 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045691 Fup NA 0.1001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045691 Vd NA 1.822 L/kg 1compartment NA NA Human Human -DTXSID3045691 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3045691 TK.Half.Life NA 25.57 hours 1compartment NA NA Human Human -DTXSID3045691 Css NA 1.94 mg/L 3compartmentss NA 50% Human Human -DTXSID3045691 Css NA 10.75 mg/L 3compartmentss NA 95% Human Human -DTXSID3045691 Css NA 1.36 mg/L PBTK NA 50% Human Human -DTXSID3045691 Css NA 6.908 mg/L PBTK NA 95% Human Human -DTXSID3045691 Clint NA 2.821 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045691 Fup NA 0.1001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045691 Vd NA 1.511 L/kg 1compartment NA NA Rat Human -DTXSID3045691 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3045691 TK.Half.Life NA 10.1 hours 1compartment NA NA Rat Human -DTXSID3045691 Css NA 0.9465 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045691 Css NA 4.057 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045691 Css NA 0.6303 mg/L PBTK NA 50% Rat Human -DTXSID3045691 Css NA 2.377 mg/L PBTK NA 95% Rat Human -DTXSID3045693 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045693 Fup NA 0.0123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045693 Vd NA 0.1906 L/kg 1compartment NA NA Human Human -DTXSID3045693 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID3045693 TK.Half.Life NA 100.2 hours 1compartment NA NA Human Human -DTXSID3045693 Css NA 90.58 mg/L 3compartmentss NA 50% Human Human -DTXSID3045693 Css NA 560.6 mg/L 3compartmentss NA 95% Human Human -DTXSID3045693 Css NA 53.13 mg/L PBTK NA 50% Human Human -DTXSID3045693 Css NA 323.6 mg/L PBTK NA 95% Human Human -DTXSID3045693 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045693 Fup NA 0.0123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045693 Vd NA 0.1864 L/kg 1compartment NA NA Rat Human -DTXSID3045693 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID3045693 TK.Half.Life NA 33.4 hours 1compartment NA NA Rat Human -DTXSID3045693 Css NA 26.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045693 Css NA 138.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045693 Css NA 14.28 mg/L PBTK NA 50% Rat Human -DTXSID3045693 Css NA 74.92 mg/L PBTK NA 95% Rat Human -DTXSID3045695 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045695 Fup NA 0.1077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045695 Vd NA 0.3262 L/kg 1compartment NA NA Human Human +DTXSID3045649 Css NA 0.01428 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045649 Css NA 0.1048 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045649 Css NA 0.0112 mg/L PBTK NA 50% Rat Human +DTXSID3045649 Css NA 0.06786 mg/L PBTK NA 95% Rat Human +DTXSID3045691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045691 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045691 Vd NA 1.753 L/kg 1compartment NA NA Human Human +DTXSID3045691 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3045691 TK.Half.Life NA 2.82 hours 1compartment NA NA Human Human +DTXSID3045691 Css NA 0.1006 mg/L 3compartmentss NA 50% Human Human +DTXSID3045691 Css NA 0.7201 mg/L 3compartmentss NA 95% Human Human +DTXSID3045691 Css NA 0.07845 mg/L PBTK NA 50% Human Human +DTXSID3045691 Css NA 0.5184 mg/L PBTK NA 95% Human Human +DTXSID3045691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045691 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045691 Vd NA 1.564 L/kg 1compartment NA NA Rat Human +DTXSID3045691 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3045691 TK.Half.Life NA 1.321 hours 1compartment NA NA Rat Human +DTXSID3045691 Css NA 0.01263 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045691 Css NA 0.06881 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045691 Css NA 0.00987 mg/L PBTK NA 50% Rat Human +DTXSID3045691 Css NA 0.04907 mg/L PBTK NA 95% Rat Human +DTXSID3045693 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045693 Fup 0.0512 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045693 Vd NA 0.3101 L/kg 1compartment NA NA Human Human +DTXSID3045693 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3045693 TK.Half.Life NA 1.324 hours 1compartment NA NA Human Human +DTXSID3045693 Css NA 0.5968 mg/L 3compartmentss NA 50% Human Human +DTXSID3045693 Css NA 5.011 mg/L 3compartmentss NA 95% Human Human +DTXSID3045693 Css NA 0.3679 mg/L PBTK NA 50% Human Human +DTXSID3045693 Css NA 2.998 mg/L PBTK NA 95% Human Human +DTXSID3045693 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045693 Fup 0.0512 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045693 Vd NA 0.2988 L/kg 1compartment NA NA Rat Human +DTXSID3045693 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3045693 TK.Half.Life NA 0.8006 hours 1compartment NA NA Rat Human +DTXSID3045693 Css NA 0.07731 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045693 Css NA 0.5208 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045693 Css NA 0.04636 mg/L PBTK NA 50% Rat Human +DTXSID3045693 Css NA 0.2993 mg/L PBTK NA 95% Rat Human +DTXSID3045695 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045695 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045695 Vd NA 0.5269 L/kg 1compartment NA NA Human Human DTXSID3045695 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045695 TK.Half.Life NA 0.9452 hours 1compartment NA NA Human Human -DTXSID3045695 Css NA 0.3478 mg/L 3compartmentss NA 50% Human Human -DTXSID3045695 Css NA 2.702 mg/L 3compartmentss NA 95% Human Human -DTXSID3045695 Css NA 0.2169 mg/L PBTK NA 50% Human Human -DTXSID3045695 Css NA 1.637 mg/L PBTK NA 95% Human Human -DTXSID3045695 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045695 Fup NA 0.1077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045695 Vd NA 0.3086 L/kg 1compartment NA NA Rat Human +DTXSID3045695 TK.Half.Life NA 1.122 hours 1compartment NA NA Human Human +DTXSID3045695 Css NA 0.176 mg/L 3compartmentss NA 50% Human Human +DTXSID3045695 Css NA 1.144 mg/L 3compartmentss NA 95% Human Human +DTXSID3045695 Css NA 0.1276 mg/L PBTK NA 50% Human Human +DTXSID3045695 Css NA 0.7462 mg/L PBTK NA 95% Human Human +DTXSID3045695 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045695 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045695 Vd NA 0.5106 L/kg 1compartment NA NA Rat Human DTXSID3045695 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045695 TK.Half.Life NA 0.5348 hours 1compartment NA NA Rat Human -DTXSID3045695 Css NA 0.1938 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045695 Css NA 1.115 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045695 Css NA 0.1137 mg/L PBTK NA 50% Rat Human -DTXSID3045695 Css NA 0.6255 mg/L PBTK NA 95% Rat Human -DTXSID3045697 Clint NA 2.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045697 Fup NA 0.2147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045697 Vd NA 0.3514 L/kg 1compartment NA NA Human Human +DTXSID3045695 TK.Half.Life NA 0.6086 hours 1compartment NA NA Rat Human +DTXSID3045695 Css NA 0.02039 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045695 Css NA 0.09627 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045695 Css NA 0.01481 mg/L PBTK NA 50% Rat Human +DTXSID3045695 Css NA 0.06133 mg/L PBTK NA 95% Rat Human +DTXSID3045697 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045697 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045697 Vd NA 0.4791 L/kg 1compartment NA NA Human Human DTXSID3045697 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045697 TK.Half.Life NA 2.575 hours 1compartment NA NA Human Human -DTXSID3045697 Css NA 0.8703 mg/L 3compartmentss NA 50% Human Human -DTXSID3045697 Css NA 4.175 mg/L 3compartmentss NA 95% Human Human -DTXSID3045697 Css NA 0.5748 mg/L PBTK NA 50% Human Human -DTXSID3045697 Css NA 2.58 mg/L PBTK NA 95% Human Human -DTXSID3045697 Clint NA 2.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045697 Fup NA 0.2147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045697 Vd NA 0.3537 L/kg 1compartment NA NA Rat Human +DTXSID3045697 TK.Half.Life NA 0.9634 hours 1compartment NA NA Human Human +DTXSID3045697 Css NA 0.1612 mg/L 3compartmentss NA 50% Human Human +DTXSID3045697 Css NA 1.072 mg/L 3compartmentss NA 95% Human Human +DTXSID3045697 Css NA 0.1173 mg/L PBTK NA 50% Human Human +DTXSID3045697 Css NA 0.7022 mg/L PBTK NA 95% Human Human +DTXSID3045697 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045697 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045697 Vd NA 0.4846 L/kg 1compartment NA NA Rat Human DTXSID3045697 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045697 TK.Half.Life NA 1.417 hours 1compartment NA NA Rat Human -DTXSID3045697 Css NA 0.3976 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045697 Css NA 1.378 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045697 Css NA 0.25 mg/L PBTK NA 50% Rat Human -DTXSID3045697 Css NA 0.7952 mg/L PBTK NA 95% Rat Human -DTXSID3045699 Clint NA 6.355 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045699 Fup NA 0.1061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045699 Vd NA 1.136 L/kg 1compartment NA NA Human Human +DTXSID3045697 TK.Half.Life NA 0.5436 hours 1compartment NA NA Rat Human +DTXSID3045697 Css NA 0.01884 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045697 Css NA 0.09299 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045697 Css NA 0.01362 mg/L PBTK NA 50% Rat Human +DTXSID3045697 Css NA 0.05946 mg/L PBTK NA 95% Rat Human +DTXSID3045699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045699 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045699 Vd NA 1.183 L/kg 1compartment NA NA Human Human DTXSID3045699 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045699 TK.Half.Life NA 7.25 hours 1compartment NA NA Human Human -DTXSID3045699 Css NA 0.8916 mg/L 3compartmentss NA 50% Human Human -DTXSID3045699 Css NA 5.727 mg/L 3compartmentss NA 95% Human Human -DTXSID3045699 Css NA 0.5863 mg/L PBTK NA 50% Human Human -DTXSID3045699 Css NA 3.542 mg/L PBTK NA 95% Human Human -DTXSID3045699 Clint NA 6.355 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045699 Fup NA 0.1061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045699 Vd NA 0.8875 L/kg 1compartment NA NA Rat Human +DTXSID3045699 TK.Half.Life NA 2.887 hours 1compartment NA NA Human Human +DTXSID3045699 Css NA 0.2453 mg/L 3compartmentss NA 50% Human Human +DTXSID3045699 Css NA 1.981 mg/L 3compartmentss NA 95% Human Human +DTXSID3045699 Css NA 0.1629 mg/L PBTK NA 50% Human Human +DTXSID3045699 Css NA 1.238 mg/L PBTK NA 95% Human Human +DTXSID3045699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045699 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045699 Vd NA 0.9249 L/kg 1compartment NA NA Rat Human DTXSID3045699 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045699 TK.Half.Life NA 3.103 hours 1compartment NA NA Rat Human -DTXSID3045699 Css NA 0.4688 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045699 Css NA 2.374 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045699 Css NA 0.2902 mg/L PBTK NA 50% Rat Human -DTXSID3045699 Css NA 1.376 mg/L PBTK NA 95% Rat Human -DTXSID3045770 Clint NA 8.048 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045770 Fup NA 0.3276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045770 Vd NA 1.956 L/kg 1compartment NA NA Human Human +DTXSID3045699 TK.Half.Life NA 1.211 hours 1compartment NA NA Rat Human +DTXSID3045699 Css NA 0.03164 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045699 Css NA 0.1976 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045699 Css NA 0.02054 mg/L PBTK NA 50% Rat Human +DTXSID3045699 Css NA 0.1204 mg/L PBTK NA 95% Rat Human +DTXSID3045770 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045770 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045770 Vd NA 1.701 L/kg 1compartment NA NA Human Human DTXSID3045770 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045770 TK.Half.Life NA 3.65 hours 1compartment NA NA Human Human -DTXSID3045770 Css NA 0.128 mg/L 3compartmentss NA 50% Human Human -DTXSID3045770 Css NA 0.9227 mg/L 3compartmentss NA 95% Human Human -DTXSID3045770 Css NA 0.1167 mg/L PBTK NA 50% Human Human -DTXSID3045770 Css NA 0.7027 mg/L PBTK NA 95% Human Human -DTXSID3045770 Clint NA 8.048 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045770 Fup NA 0.3276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045770 Vd NA 1.969 L/kg 1compartment NA NA Rat Human +DTXSID3045770 TK.Half.Life NA 2.828 hours 1compartment NA NA Human Human +DTXSID3045770 Css NA 0.1113 mg/L 3compartmentss NA 50% Human Human +DTXSID3045770 Css NA 0.9336 mg/L 3compartmentss NA 95% Human Human +DTXSID3045770 Css NA 0.102 mg/L PBTK NA 50% Human Human +DTXSID3045770 Css NA 0.6687 mg/L PBTK NA 95% Human Human +DTXSID3045770 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045770 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045770 Vd NA 1.717 L/kg 1compartment NA NA Rat Human DTXSID3045770 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045770 TK.Half.Life NA 2.118 hours 1compartment NA NA Rat Human -DTXSID3045770 Css NA 0.06668 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045770 Css NA 0.3679 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045770 Css NA 0.0594 mg/L PBTK NA 50% Rat Human -DTXSID3045770 Css NA 0.2605 mg/L PBTK NA 95% Rat Human -DTXSID3045772 Clint NA 13.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045772 Fup NA 0.9445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045772 Vd NA 8.805 L/kg 1compartment NA NA Human Human +DTXSID3045770 TK.Half.Life NA 1.604 hours 1compartment NA NA Rat Human +DTXSID3045770 Css NA 0.01264 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045770 Css NA 0.08189 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045770 Css NA 0.01183 mg/L PBTK NA 50% Rat Human +DTXSID3045770 Css NA 0.05766 mg/L PBTK NA 95% Rat Human +DTXSID3045772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045772 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045772 Vd NA 2.11 L/kg 1compartment NA NA Human Human DTXSID3045772 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045772 TK.Half.Life NA 3.635 hours 1compartment NA NA Human Human -DTXSID3045772 Css NA 0.01118 mg/L 3compartmentss NA 50% Human Human -DTXSID3045772 Css NA 0.09676 mg/L 3compartmentss NA 95% Human Human -DTXSID3045772 Css NA 0.0259 mg/L PBTK NA 50% Human Human -DTXSID3045772 Css NA 0.1595 mg/L PBTK NA 95% Human Human -DTXSID3045772 Clint NA 13.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045772 Fup NA 0.9445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045772 Vd NA 9.044 L/kg 1compartment NA NA Rat Human +DTXSID3045772 TK.Half.Life NA 3.052 hours 1compartment NA NA Human Human +DTXSID3045772 Css NA 0.08068 mg/L 3compartmentss NA 50% Human Human +DTXSID3045772 Css NA 0.6264 mg/L 3compartmentss NA 95% Human Human +DTXSID3045772 Css NA 0.07361 mg/L PBTK NA 50% Human Human +DTXSID3045772 Css NA 0.4998 mg/L PBTK NA 95% Human Human +DTXSID3045772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045772 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045772 Vd NA 2.106 L/kg 1compartment NA NA Rat Human DTXSID3045772 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045772 TK.Half.Life NA 2.04 hours 1compartment NA NA Rat Human -DTXSID3045772 Css NA 0.00531 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045772 Css NA 0.03789 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045772 Css NA 0.01328 mg/L PBTK NA 50% Rat Human -DTXSID3045772 Css NA 0.06666 mg/L PBTK NA 95% Rat Human -DTXSID3045774 Clint NA 11.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045774 Fup NA 0.1619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045774 Vd NA 2.137 L/kg 1compartment NA NA Human Human +DTXSID3045772 TK.Half.Life NA 1.76 hours 1compartment NA NA Rat Human +DTXSID3045772 Css NA 0.009971 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045772 Css NA 0.06096 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045772 Css NA 0.009233 mg/L PBTK NA 50% Rat Human +DTXSID3045772 Css NA 0.04809 mg/L PBTK NA 95% Rat Human +DTXSID3045774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045774 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045774 Vd NA 2.238 L/kg 1compartment NA NA Human Human DTXSID3045774 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045774 TK.Half.Life NA 4.351 hours 1compartment NA NA Human Human -DTXSID3045774 Css NA 0.154 mg/L 3compartmentss NA 50% Human Human -DTXSID3045774 Css NA 1.233 mg/L 3compartmentss NA 95% Human Human -DTXSID3045774 Css NA 0.1447 mg/L PBTK NA 50% Human Human -DTXSID3045774 Css NA 0.9615 mg/L PBTK NA 95% Human Human -DTXSID3045774 Clint NA 11.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045774 Fup NA 0.1619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045774 Vd NA 2.11 L/kg 1compartment NA NA Rat Human +DTXSID3045774 TK.Half.Life NA 2.574 hours 1compartment NA NA Human Human +DTXSID3045774 Css NA 0.0531 mg/L 3compartmentss NA 50% Human Human +DTXSID3045774 Css NA 0.4365 mg/L 3compartmentss NA 95% Human Human +DTXSID3045774 Css NA 0.05329 mg/L PBTK NA 50% Human Human +DTXSID3045774 Css NA 0.3592 mg/L PBTK NA 95% Human Human +DTXSID3045774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045774 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045774 Vd NA 2.212 L/kg 1compartment NA NA Rat Human DTXSID3045774 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045774 TK.Half.Life NA 2.593 hours 1compartment NA NA Rat Human -DTXSID3045774 Css NA 0.08127 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045774 Css NA 0.5025 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045774 Css NA 0.07416 mg/L PBTK NA 50% Rat Human -DTXSID3045774 Css NA 0.3716 mg/L PBTK NA 95% Rat Human +DTXSID3045774 TK.Half.Life NA 1.436 hours 1compartment NA NA Rat Human +DTXSID3045774 Css NA 0.006567 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045774 Css NA 0.04152 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045774 Css NA 0.006759 mg/L PBTK NA 50% Rat Human +DTXSID3045774 Css NA 0.03544 mg/L PBTK NA 95% Rat Human DTXSID3045776 Clint NA 1.579 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3045776 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045776 Vd NA 0.9642 L/kg 1compartment NA NA Human Human +DTXSID3045776 Vd NA 1.045 L/kg 1compartment NA NA Human Human DTXSID3045776 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045776 TK.Half.Life NA 2.013 hours 1compartment NA NA Human Human -DTXSID3045776 Css NA 0.2259 mg/L 3compartmentss NA 50% Human Human -DTXSID3045776 Css NA 1.654 mg/L 3compartmentss NA 95% Human Human -DTXSID3045776 Css NA 0.1977 mg/L PBTK NA 50% Human Human -DTXSID3045776 Css NA 1.164 mg/L PBTK NA 95% Human Human +DTXSID3045776 TK.Half.Life NA 2.187 hours 1compartment NA NA Human Human +DTXSID3045776 Css NA 0.1839 mg/L 3compartmentss NA 50% Human Human +DTXSID3045776 Css NA 1.364 mg/L 3compartmentss NA 95% Human Human +DTXSID3045776 Css NA 0.1632 mg/L PBTK NA 50% Human Human +DTXSID3045776 Css NA 0.952 mg/L PBTK NA 95% Human Human DTXSID3045776 Clint NA 1.579 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3045776 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045776 Vd NA 0.9734 L/kg 1compartment NA NA Rat Human +DTXSID3045776 Vd NA 1.039 L/kg 1compartment NA NA Rat Human DTXSID3045776 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045776 TK.Half.Life NA 1.019 hours 1compartment NA NA Rat Human -DTXSID3045776 Css NA 0.08953 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045776 Css NA 0.6093 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045776 Css NA 0.07803 mg/L PBTK NA 50% Rat Human -DTXSID3045776 Css NA 0.3757 mg/L PBTK NA 95% Rat Human -DTXSID3045803 Clint NA 58.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045803 Fup NA 0.1066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045803 Vd NA 2.832 L/kg 1compartment NA NA Human Human +DTXSID3045776 TK.Half.Life NA 1.087 hours 1compartment NA NA Rat Human +DTXSID3045776 Css NA 0.005151 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045776 Css NA 0.04772 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045776 Css NA 0.00458 mg/L PBTK NA 50% Rat Human +DTXSID3045776 Css NA 0.03313 mg/L PBTK NA 95% Rat Human +DTXSID3045778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045778 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045778 Vd NA 3.273 L/kg 1compartment NA NA Human Human +DTXSID3045778 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3045778 TK.Half.Life NA 5.462 hours 1compartment NA NA Human Human +DTXSID3045778 Css NA 0.1008 mg/L 3compartmentss NA 50% Human Human +DTXSID3045778 Css NA 0.7257 mg/L 3compartmentss NA 95% Human Human +DTXSID3045778 Css NA 0.09355 mg/L PBTK NA 50% Human Human +DTXSID3045778 Css NA 0.5959 mg/L PBTK NA 95% Human Human +DTXSID3045778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045778 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045778 Vd NA 2.986 L/kg 1compartment NA NA Rat Human +DTXSID3045778 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3045778 TK.Half.Life NA 2.329 hours 1compartment NA NA Rat Human +DTXSID3045778 Css NA 0.01244 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045778 Css NA 0.07001 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045778 Css NA 0.01181 mg/L PBTK NA 50% Rat Human +DTXSID3045778 Css NA 0.05914 mg/L PBTK NA 95% Rat Human +DTXSID3045803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045803 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045803 Vd NA 1.297 L/kg 1compartment NA NA Human Human DTXSID3045803 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045803 TK.Half.Life NA 4.077 hours 1compartment NA NA Human Human -DTXSID3045803 Css NA 0.09762 mg/L 3compartmentss NA 50% Human Human -DTXSID3045803 Css NA 0.7509 mg/L 3compartmentss NA 95% Human Human -DTXSID3045803 Css NA 0.07615 mg/L PBTK NA 50% Human Human -DTXSID3045803 Css NA 0.5235 mg/L PBTK NA 95% Human Human -DTXSID3045803 Clint NA 58.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045803 Fup NA 0.1066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045803 Vd NA 2.397 L/kg 1compartment NA NA Rat Human +DTXSID3045803 TK.Half.Life NA 1.765 hours 1compartment NA NA Human Human +DTXSID3045803 Css NA 0.07436 mg/L 3compartmentss NA 50% Human Human +DTXSID3045803 Css NA 0.5575 mg/L 3compartmentss NA 95% Human Human +DTXSID3045803 Css NA 0.05843 mg/L PBTK NA 50% Human Human +DTXSID3045803 Css NA 0.3882 mg/L PBTK NA 95% Human Human +DTXSID3045803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045803 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045803 Vd NA 1.293 L/kg 1compartment NA NA Rat Human DTXSID3045803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045803 TK.Half.Life NA 1.494 hours 1compartment NA NA Rat Human -DTXSID3045803 Css NA 0.05358 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045803 Css NA 0.3363 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045803 Css NA 0.03995 mg/L PBTK NA 50% Rat Human -DTXSID3045803 Css NA 0.2309 mg/L PBTK NA 95% Rat Human -DTXSID3045805 Clint NA 56.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045805 Fup NA 0.3508 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045805 Vd NA 2.453 L/kg 1compartment NA NA Human Human +DTXSID3045803 TK.Half.Life NA 0.9669 hours 1compartment NA NA Rat Human +DTXSID3045803 Css NA 0.009348 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045803 Css NA 0.05237 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045803 Css NA 0.007269 mg/L PBTK NA 50% Rat Human +DTXSID3045803 Css NA 0.03741 mg/L PBTK NA 95% Rat Human +DTXSID3045805 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045805 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045805 Vd NA 1.824 L/kg 1compartment NA NA Human Human DTXSID3045805 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045805 TK.Half.Life NA 1.727 hours 1compartment NA NA Human Human -DTXSID3045805 Css NA 0.01642 mg/L 3compartmentss NA 50% Human Human -DTXSID3045805 Css NA 0.1434 mg/L 3compartmentss NA 95% Human Human -DTXSID3045805 Css NA 0.01662 mg/L PBTK NA 50% Human Human -DTXSID3045805 Css NA 0.1196 mg/L PBTK NA 95% Human Human -DTXSID3045805 Clint NA 56.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045805 Fup NA 0.3508 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045805 Vd NA 2.477 L/kg 1compartment NA NA Rat Human +DTXSID3045805 TK.Half.Life NA 3.301 hours 1compartment NA NA Human Human +DTXSID3045805 Css NA 0.1226 mg/L 3compartmentss NA 50% Human Human +DTXSID3045805 Css NA 0.9226 mg/L 3compartmentss NA 95% Human Human +DTXSID3045805 Css NA 0.1129 mg/L PBTK NA 50% Human Human +DTXSID3045805 Css NA 0.6934 mg/L PBTK NA 95% Human Human +DTXSID3045805 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045805 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045805 Vd NA 1.836 L/kg 1compartment NA NA Rat Human DTXSID3045805 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045805 TK.Half.Life NA 0.8671 hours 1compartment NA NA Rat Human -DTXSID3045805 Css NA 0.008773 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045805 Css NA 0.06282 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045805 Css NA 0.008696 mg/L PBTK NA 50% Rat Human -DTXSID3045805 Css NA 0.04986 mg/L PBTK NA 95% Rat Human -DTXSID3045807 Clint NA 21.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045807 Fup NA 0.627 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045807 Vd NA 2.709 L/kg 1compartment NA NA Human Human +DTXSID3045805 TK.Half.Life NA 1.891 hours 1compartment NA NA Rat Human +DTXSID3045805 Css NA 0.01393 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045805 Css NA 0.08266 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045805 Css NA 0.01317 mg/L PBTK NA 50% Rat Human +DTXSID3045805 Css NA 0.05981 mg/L PBTK NA 95% Rat Human +DTXSID3045807 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045807 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045807 Vd NA 1.385 L/kg 1compartment NA NA Human Human DTXSID3045807 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045807 TK.Half.Life NA 2.301 hours 1compartment NA NA Human Human -DTXSID3045807 Css NA 0.03426 mg/L 3compartmentss NA 50% Human Human -DTXSID3045807 Css NA 0.3521 mg/L 3compartmentss NA 95% Human Human -DTXSID3045807 Css NA 0.03449 mg/L PBTK NA 50% Human Human -DTXSID3045807 Css NA 0.2777 mg/L PBTK NA 95% Human Human -DTXSID3045807 Clint NA 21.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045807 Fup NA 0.627 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045807 Vd NA 2.486 L/kg 1compartment NA NA Rat Human +DTXSID3045807 TK.Half.Life NA 3.32 hours 1compartment NA NA Human Human +DTXSID3045807 Css NA 0.1926 mg/L 3compartmentss NA 50% Human Human +DTXSID3045807 Css NA 1.285 mg/L 3compartmentss NA 95% Human Human +DTXSID3045807 Css NA 0.1543 mg/L PBTK NA 50% Human Human +DTXSID3045807 Css NA 0.9093 mg/L PBTK NA 95% Human Human +DTXSID3045807 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045807 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045807 Vd NA 1.316 L/kg 1compartment NA NA Rat Human DTXSID3045807 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045807 TK.Half.Life NA 0.9881 hours 1compartment NA NA Rat Human -DTXSID3045807 Css NA 0.01779 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045807 Css NA 0.1612 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045807 Css NA 0.01761 mg/L PBTK NA 50% Rat Human -DTXSID3045807 Css NA 0.1185 mg/L PBTK NA 95% Rat Human -DTXSID3045809 Clint NA 6.817 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045809 Fup NA 0.1327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045809 Vd NA 1.668 L/kg 1compartment NA NA Human Human +DTXSID3045807 TK.Half.Life NA 1.768 hours 1compartment NA NA Rat Human +DTXSID3045807 Css NA 0.02208 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045807 Css NA 0.113 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045807 Css NA 0.01789 mg/L PBTK NA 50% Rat Human +DTXSID3045807 Css NA 0.07637 mg/L PBTK NA 95% Rat Human +DTXSID3045809 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045809 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045809 Vd NA 1.93 L/kg 1compartment NA NA Human Human DTXSID3045809 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045809 TK.Half.Life NA 7.502 hours 1compartment NA NA Human Human -DTXSID3045809 Css NA 0.5241 mg/L 3compartmentss NA 50% Human Human -DTXSID3045809 Css NA 3.998 mg/L 3compartmentss NA 95% Human Human -DTXSID3045809 Css NA 0.3927 mg/L PBTK NA 50% Human Human -DTXSID3045809 Css NA 2.635 mg/L PBTK NA 95% Human Human -DTXSID3045809 Clint NA 6.817 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045809 Fup NA 0.1327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045809 Vd NA 1.562 L/kg 1compartment NA NA Rat Human +DTXSID3045809 TK.Half.Life NA 5.996 hours 1compartment NA NA Human Human +DTXSID3045809 Css NA 0.2788 mg/L 3compartmentss NA 50% Human Human +DTXSID3045809 Css NA 1.57 mg/L 3compartmentss NA 95% Human Human +DTXSID3045809 Css NA 0.2148 mg/L PBTK NA 50% Human Human +DTXSID3045809 Css NA 1.1 mg/L PBTK NA 95% Human Human +DTXSID3045809 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045809 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045809 Vd NA 1.526 L/kg 1compartment NA NA Rat Human DTXSID3045809 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045809 TK.Half.Life NA 4.065 hours 1compartment NA NA Rat Human -DTXSID3045809 Css NA 0.2756 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045809 Css NA 1.543 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045809 Css NA 0.1974 mg/L PBTK NA 50% Rat Human -DTXSID3045809 Css NA 0.9455 mg/L PBTK NA 95% Rat Human -DTXSID3045851 Clint NA 5.059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045851 Fup NA 0.1404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045851 Vd NA 0.5061 L/kg 1compartment NA NA Human Human -DTXSID3045851 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045851 TK.Half.Life NA 2.831 hours 1compartment NA NA Human Human -DTXSID3045851 Css NA 0.7727 mg/L 3compartmentss NA 50% Human Human -DTXSID3045851 Css NA 4.863 mg/L 3compartmentss NA 95% Human Human -DTXSID3045851 Css NA 0.4914 mg/L PBTK NA 50% Human Human -DTXSID3045851 Css NA 2.908 mg/L PBTK NA 95% Human Human -DTXSID3045851 Clint NA 5.059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045851 Fup NA 0.1404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045851 Vd NA 0.4443 L/kg 1compartment NA NA Rat Human +DTXSID3045809 TK.Half.Life NA 2.107 hours 1compartment NA NA Rat Human +DTXSID3045809 Css NA 0.0326 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045809 Css NA 0.1364 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045809 Css NA 0.02511 mg/L PBTK NA 50% Rat Human +DTXSID3045809 Css NA 0.09463 mg/L PBTK NA 95% Rat Human +DTXSID3045851 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045851 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045851 Vd NA 0.7442 L/kg 1compartment NA NA Human Human +DTXSID3045851 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3045851 TK.Half.Life NA 14.31 hours 1compartment NA NA Human Human +DTXSID3045851 Css NA 2.107 mg/L 3compartmentss NA 50% Human Human +DTXSID3045851 Css NA 8.537 mg/L 3compartmentss NA 95% Human Human +DTXSID3045851 Css NA 1.538 mg/L PBTK NA 50% Human Human +DTXSID3045851 Css NA 5.428 mg/L PBTK NA 95% Human Human +DTXSID3045851 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045851 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045851 Vd NA 0.6682 L/kg 1compartment NA NA Rat Human DTXSID3045851 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045851 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human -DTXSID3045851 Css NA 0.393 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045851 Css NA 1.919 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045851 Css NA 0.2356 mg/L PBTK NA 50% Rat Human -DTXSID3045851 Css NA 1.081 mg/L PBTK NA 95% Rat Human -DTXSID3045855 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045855 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045855 Vd NA 0.5966 L/kg 1compartment NA NA Human Human +DTXSID3045851 TK.Half.Life NA 4.26 hours 1compartment NA NA Rat Human +DTXSID3045851 Css NA 0.1336 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045851 Css NA 0.4713 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045851 Css NA 0.09658 mg/L PBTK NA 50% Rat Human +DTXSID3045851 Css NA 0.2895 mg/L PBTK NA 95% Rat Human +DTXSID3045855 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045855 Fup 0.846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045855 Vd NA 0.5461 L/kg 1compartment NA NA Human Human DTXSID3045855 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045855 TK.Half.Life NA 3.862 hours 1compartment NA NA Human Human -DTXSID3045855 Css NA 0.8894 mg/L 3compartmentss NA 50% Human Human -DTXSID3045855 Css NA 5.625 mg/L 3compartmentss NA 95% Human Human -DTXSID3045855 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID3045855 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID3045855 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045855 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045855 Vd NA 0.6375 L/kg 1compartment NA NA Rat Human +DTXSID3045855 TK.Half.Life NA 4.176 hours 1compartment NA NA Human Human +DTXSID3045855 Css NA 0.891 mg/L 3compartmentss NA 50% Human Human +DTXSID3045855 Css NA 5.097 mg/L 3compartmentss NA 95% Human Human +DTXSID3045855 Css NA 0.6809 mg/L PBTK NA 50% Human Human +DTXSID3045855 Css NA 3.248 mg/L PBTK NA 95% Human Human +DTXSID3045855 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045855 Fup 0.846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045855 Vd NA 0.582 L/kg 1compartment NA NA Rat Human DTXSID3045855 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045855 TK.Half.Life NA 1.405 hours 1compartment NA NA Rat Human -DTXSID3045855 Css NA 0.2249 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045855 Css NA 1.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045855 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID3045855 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID3045857 Clint NA 15.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045857 Fup NA 0.1528 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045857 Vd NA 0.5062 L/kg 1compartment NA NA Human Human +DTXSID3045855 TK.Half.Life NA 1.517 hours 1compartment NA NA Rat Human +DTXSID3045855 Css NA 0.02349 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045855 Css NA 0.1513 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045855 Css NA 0.01738 mg/L PBTK NA 50% Rat Human +DTXSID3045855 Css NA 0.09363 mg/L PBTK NA 95% Rat Human +DTXSID3045857 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045857 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045857 Vd NA 0.5963 L/kg 1compartment NA NA Human Human DTXSID3045857 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045857 TK.Half.Life NA 1.219 hours 1compartment NA NA Human Human -DTXSID3045857 Css NA 0.2453 mg/L 3compartmentss NA 50% Human Human -DTXSID3045857 Css NA 1.776 mg/L 3compartmentss NA 95% Human Human -DTXSID3045857 Css NA 0.1586 mg/L PBTK NA 50% Human Human -DTXSID3045857 Css NA 1.112 mg/L PBTK NA 95% Human Human -DTXSID3045857 Clint NA 15.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045857 Fup NA 0.1528 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045857 Vd NA 0.4596 L/kg 1compartment NA NA Rat Human +DTXSID3045857 TK.Half.Life NA 2.035 hours 1compartment NA NA Human Human +DTXSID3045857 Css NA 0.1764 mg/L 3compartmentss NA 50% Human Human +DTXSID3045857 Css NA 1.157 mg/L 3compartmentss NA 95% Human Human +DTXSID3045857 Css NA 0.1206 mg/L PBTK NA 50% Human Human +DTXSID3045857 Css NA 0.7238 mg/L PBTK NA 95% Human Human +DTXSID3045857 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045857 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045857 Vd NA 0.5419 L/kg 1compartment NA NA Rat Human DTXSID3045857 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045857 TK.Half.Life NA 0.643 hours 1compartment NA NA Rat Human -DTXSID3045857 Css NA 0.1346 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045857 Css NA 0.7575 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045857 Css NA 0.08214 mg/L PBTK NA 50% Rat Human -DTXSID3045857 Css NA 0.4412 mg/L PBTK NA 95% Rat Human -DTXSID3045859 Clint NA 34.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045859 Fup NA 0.0767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045859 Vd NA 2.291 L/kg 1compartment NA NA Human Human +DTXSID3045857 TK.Half.Life NA 1.072 hours 1compartment NA NA Rat Human +DTXSID3045857 Css NA 0.001726 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045857 Css NA 0.009556 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045857 Css NA 0.001124 mg/L PBTK NA 50% Rat Human +DTXSID3045857 Css NA 0.005807 mg/L PBTK NA 95% Rat Human +DTXSID3045859 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045859 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045859 Vd NA 2.686 L/kg 1compartment NA NA Human Human DTXSID3045859 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045859 TK.Half.Life NA 5.093 hours 1compartment NA NA Human Human -DTXSID3045859 Css NA 0.2145 mg/L 3compartmentss NA 50% Human Human -DTXSID3045859 Css NA 1.685 mg/L 3compartmentss NA 95% Human Human -DTXSID3045859 Css NA 0.1553 mg/L PBTK NA 50% Human Human -DTXSID3045859 Css NA 1.118 mg/L PBTK NA 95% Human Human -DTXSID3045859 Clint NA 34.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045859 Fup NA 0.0767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045859 Vd NA 1.94 L/kg 1compartment NA NA Rat Human +DTXSID3045859 TK.Half.Life NA 7.225 hours 1compartment NA NA Human Human +DTXSID3045859 Css NA 0.2552 mg/L 3compartmentss NA 50% Human Human +DTXSID3045859 Css NA 1.847 mg/L 3compartmentss NA 95% Human Human +DTXSID3045859 Css NA 0.1953 mg/L PBTK NA 50% Human Human +DTXSID3045859 Css NA 1.323 mg/L PBTK NA 95% Human Human +DTXSID3045859 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045859 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045859 Vd NA 2.269 L/kg 1compartment NA NA Rat Human DTXSID3045859 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045859 TK.Half.Life NA 2.087 hours 1compartment NA NA Rat Human -DTXSID3045859 Css NA 0.1189 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045859 Css NA 0.738 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045859 Css NA 0.08274 mg/L PBTK NA 50% Rat Human -DTXSID3045859 Css NA 0.4727 mg/L PBTK NA 95% Rat Human +DTXSID3045859 TK.Half.Life NA 2.697 hours 1compartment NA NA Rat Human +DTXSID3045859 Css NA 0.03214 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045859 Css NA 0.1993 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045859 Css NA 0.0245 mg/L PBTK NA 50% Rat Human +DTXSID3045859 Css NA 0.1369 mg/L PBTK NA 95% Rat Human DTXSID3045930 Clint 6.61 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID3045930 Fup NA 0.0994 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045930 Vd NA 1.446 L/kg 1compartment NA NA Human Human -DTXSID3045930 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045930 TK.Half.Life NA 10.17 hours 1compartment NA NA Human Human -DTXSID3045930 Css NA 0.969 mg/L 3compartmentss NA 50% Human Human -DTXSID3045930 Css NA 6.5 mg/L 3compartmentss NA 95% Human Human -DTXSID3045930 Css NA 0.6415 mg/L PBTK NA 50% Human Human -DTXSID3045930 Css NA 4.052 mg/L PBTK NA 95% Human Human +DTXSID3045930 Fup 0.0538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045930 Vd NA 1.074 L/kg 1compartment NA NA Human Human +DTXSID3045930 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3045930 TK.Half.Life NA 11.86 hours 1compartment NA NA Human Human +DTXSID3045930 Css NA 1.728 mg/L 3compartmentss NA 50% Human Human +DTXSID3045930 Css NA 11.84 mg/L 3compartmentss NA 95% Human Human +DTXSID3045930 Css NA 1.085 mg/L PBTK NA 50% Human Human +DTXSID3045930 Css NA 7.196 mg/L PBTK NA 95% Human Human DTXSID3045930 Clint 6.61 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID3045930 Fup NA 0.0994 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045930 Vd NA 1.108 L/kg 1compartment NA NA Rat Human +DTXSID3045930 Fup 0.0538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045930 Vd NA 0.8192 L/kg 1compartment NA NA Rat Human DTXSID3045930 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045930 TK.Half.Life NA 3.968 hours 1compartment NA NA Rat Human -DTXSID3045930 Css NA 0.5164 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045930 Css NA 2.549 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045930 Css NA 0.3224 mg/L PBTK NA 50% Rat Human -DTXSID3045930 Css NA 1.471 mg/L PBTK NA 95% Rat Human -DTXSID3045934 Clint NA 3.084 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045934 Fup NA 0.7768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045934 Vd NA 0.8606 L/kg 1compartment NA NA Human Human +DTXSID3045930 TK.Half.Life NA 5.071 hours 1compartment NA NA Rat Human +DTXSID3045930 Css NA 0.2134 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045930 Css NA 1.077 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045930 Css NA 0.1303 mg/L PBTK NA 50% Rat Human +DTXSID3045930 Css NA 0.6229 mg/L PBTK NA 95% Rat Human +DTXSID3045934 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045934 Fup 0.726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045934 Vd NA 0.8261 L/kg 1compartment NA NA Human Human DTXSID3045934 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045934 TK.Half.Life NA 1.539 hours 1compartment NA NA Human Human -DTXSID3045934 Css NA 0.1695 mg/L 3compartmentss NA 50% Human Human -DTXSID3045934 Css NA 1.272 mg/L 3compartmentss NA 95% Human Human -DTXSID3045934 Css NA 0.1424 mg/L PBTK NA 50% Human Human -DTXSID3045934 Css NA 0.8562 mg/L PBTK NA 95% Human Human -DTXSID3045934 Clint NA 3.084 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045934 Fup NA 0.7768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045934 Vd NA 0.8608 L/kg 1compartment NA NA Rat Human +DTXSID3045934 TK.Half.Life NA 7.426 hours 1compartment NA NA Human Human +DTXSID3045934 Css NA 1.001 mg/L 3compartmentss NA 50% Human Human +DTXSID3045934 Css NA 6.667 mg/L 3compartmentss NA 95% Human Human +DTXSID3045934 Css NA 0.8384 mg/L PBTK NA 50% Human Human +DTXSID3045934 Css NA 4.273 mg/L PBTK NA 95% Human Human +DTXSID3045934 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045934 Fup 0.726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045934 Vd NA 0.8261 L/kg 1compartment NA NA Rat Human DTXSID3045934 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045934 TK.Half.Life NA 0.8158 hours 1compartment NA NA Rat Human -DTXSID3045934 Css NA 0.07578 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045934 Css NA 0.5438 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045934 Css NA 0.06272 mg/L PBTK NA 50% Rat Human -DTXSID3045934 Css NA 0.3358 mg/L PBTK NA 95% Rat Human -DTXSID3045938 Clint NA 257.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045938 Fup NA 0.3914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045938 Vd NA 2.282 L/kg 1compartment NA NA Human Human -DTXSID3045938 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045938 TK.Half.Life NA 1.336 hours 1compartment NA NA Human Human -DTXSID3045938 Css NA 0.003633 mg/L 3compartmentss NA 50% Human Human -DTXSID3045938 Css NA 0.03187 mg/L 3compartmentss NA 95% Human Human -DTXSID3045938 Css NA 0.003494 mg/L PBTK NA 50% Human Human -DTXSID3045938 Css NA 0.02583 mg/L PBTK NA 95% Human Human -DTXSID3045938 Clint NA 257.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045938 Fup NA 0.3914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045938 Vd NA 2.272 L/kg 1compartment NA NA Rat Human -DTXSID3045938 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045938 TK.Half.Life NA 0.5965 hours 1compartment NA NA Rat Human -DTXSID3045938 Css NA 0.001913 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045938 Css NA 0.01436 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045938 Css NA 0.001817 mg/L PBTK NA 50% Rat Human -DTXSID3045938 Css NA 0.01117 mg/L PBTK NA 95% Rat Human -DTXSID3045980 Clint NA 15.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045980 Fup NA 0.2963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045980 Vd NA 2.134 L/kg 1compartment NA NA Human Human -DTXSID3045980 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045980 TK.Half.Life NA 3.122 hours 1compartment NA NA Human Human -DTXSID3045980 Css NA 0.08856 mg/L 3compartmentss NA 50% Human Human -DTXSID3045980 Css NA 0.6692 mg/L 3compartmentss NA 95% Human Human -DTXSID3045980 Css NA 0.07843 mg/L PBTK NA 50% Human Human -DTXSID3045980 Css NA 0.5121 mg/L PBTK NA 95% Human Human -DTXSID3045980 Clint NA 15.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045980 Fup NA 0.2963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045980 Vd NA 2.021 L/kg 1compartment NA NA Rat Human -DTXSID3045980 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045980 TK.Half.Life NA 1.58 hours 1compartment NA NA Rat Human -DTXSID3045980 Css NA 0.04736 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045980 Css NA 0.2695 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045980 Css NA 0.04069 mg/L PBTK NA 50% Rat Human -DTXSID3045980 Css NA 0.1947 mg/L PBTK NA 95% Rat Human -DTXSID3045984 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045984 Fup NA 0.8874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045984 Vd NA 0.6373 L/kg 1compartment NA NA Human Human -DTXSID3045984 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3045984 TK.Half.Life NA 4.646 hours 1compartment NA NA Human Human -DTXSID3045984 Css NA 0.9676 mg/L 3compartmentss NA 50% Human Human -DTXSID3045984 Css NA 5.281 mg/L 3compartmentss NA 95% Human Human -DTXSID3045984 Css NA 0.7766 mg/L PBTK NA 50% Human Human -DTXSID3045984 Css NA 3.388 mg/L PBTK NA 95% Human Human -DTXSID3045984 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045984 Fup NA 0.8874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045984 Vd NA 0.6865 L/kg 1compartment NA NA Rat Human -DTXSID3045984 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3045984 TK.Half.Life NA 1.706 hours 1compartment NA NA Rat Human -DTXSID3045984 Css NA 0.2464 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045984 Css NA 1.364 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045984 Css NA 0.1914 mg/L PBTK NA 50% Rat Human -DTXSID3045984 Css NA 0.8127 mg/L PBTK NA 95% Rat Human -DTXSID3045988 Clint NA 0.02944 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045988 Fup NA 0.253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3045988 Vd NA 2.221 L/kg 1compartment NA NA Human Human -DTXSID3045988 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID3045988 TK.Half.Life NA 115.2 hours 1compartment NA NA Human Human -DTXSID3045988 Css NA 5.669 mg/L 3compartmentss NA 50% Human Human -DTXSID3045988 Css NA 17.87 mg/L 3compartmentss NA 95% Human Human -DTXSID3045988 Css NA 4.203 mg/L PBTK NA 50% Human Human -DTXSID3045988 Css NA 11.84 mg/L PBTK NA 95% Human Human -DTXSID3045988 Clint NA 0.02944 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045988 Fup NA 0.253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3045988 Vd NA 1.701 L/kg 1compartment NA NA Rat Human -DTXSID3045988 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID3045988 TK.Half.Life NA 18.35 hours 1compartment NA NA Rat Human -DTXSID3045988 Css NA 1.619 mg/L 3compartmentss NA 50% Rat Human -DTXSID3045988 Css NA 4.119 mg/L 3compartmentss NA 95% Rat Human -DTXSID3045988 Css NA 1.146 mg/L PBTK NA 50% Rat Human -DTXSID3045988 Css NA 2.536 mg/L PBTK NA 95% Rat Human -DTXSID3046083 Clint NA 27.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3045934 TK.Half.Life NA 2.513 hours 1compartment NA NA Rat Human +DTXSID3045934 Css NA 0.06016 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045934 Css NA 0.3767 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045934 Css NA 0.05046 mg/L PBTK NA 50% Rat Human +DTXSID3045934 Css NA 0.2335 mg/L PBTK NA 95% Rat Human +DTXSID3045938 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045938 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045938 Vd NA 2.093 L/kg 1compartment NA NA Human Human +DTXSID3045938 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3045938 TK.Half.Life NA 30.83 hours 1compartment NA NA Human Human +DTXSID3045938 Css NA 1.087 mg/L 3compartmentss NA 50% Human Human +DTXSID3045938 Css NA 5.769 mg/L 3compartmentss NA 95% Human Human +DTXSID3045938 Css NA 1.056 mg/L PBTK NA 50% Human Human +DTXSID3045938 Css NA 4.19 mg/L PBTK NA 95% Human Human +DTXSID3045938 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045938 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045938 Vd NA 2.1 L/kg 1compartment NA NA Rat Human +DTXSID3045938 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3045938 TK.Half.Life NA 10.4 hours 1compartment NA NA Rat Human +DTXSID3045938 Css NA 0.02612 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045938 Css NA 0.1845 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045938 Css NA 0.02594 mg/L PBTK NA 50% Rat Human +DTXSID3045938 Css NA 0.1378 mg/L PBTK NA 95% Rat Human +DTXSID3045980 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045980 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045980 Vd NA 2.022 L/kg 1compartment NA NA Human Human +DTXSID3045980 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID3045980 TK.Half.Life NA 53.9 hours 1compartment NA NA Human Human +DTXSID3045980 Css NA 2.44 mg/L 3compartmentss NA 50% Human Human +DTXSID3045980 Css NA 9.915 mg/L 3compartmentss NA 95% Human Human +DTXSID3045980 Css NA 2.106 mg/L PBTK NA 50% Human Human +DTXSID3045980 Css NA 7.008 mg/L PBTK NA 95% Human Human +DTXSID3045980 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045980 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045980 Vd NA 1.912 L/kg 1compartment NA NA Rat Human +DTXSID3045980 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3045980 TK.Half.Life NA 15.99 hours 1compartment NA NA Rat Human +DTXSID3045980 Css NA 0.155 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045980 Css NA 0.5458 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045980 Css NA 0.1345 mg/L PBTK NA 50% Rat Human +DTXSID3045980 Css NA 0.366 mg/L PBTK NA 95% Rat Human +DTXSID3045988 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045988 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3045988 Vd NA 1.629 L/kg 1compartment NA NA Human Human +DTXSID3045988 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3045988 TK.Half.Life NA 2.614 hours 1compartment NA NA Human Human +DTXSID3045988 Css NA 0.1018 mg/L 3compartmentss NA 50% Human Human +DTXSID3045988 Css NA 0.7182 mg/L 3compartmentss NA 95% Human Human +DTXSID3045988 Css NA 0.07429 mg/L PBTK NA 50% Human Human +DTXSID3045988 Css NA 0.4861 mg/L PBTK NA 95% Human Human +DTXSID3045988 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045988 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3045988 Vd NA 1.273 L/kg 1compartment NA NA Rat Human +DTXSID3045988 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3045988 TK.Half.Life NA 0.9731 hours 1compartment NA NA Rat Human +DTXSID3045988 Css NA 0.01291 mg/L 3compartmentss NA 50% Rat Human +DTXSID3045988 Css NA 0.06436 mg/L 3compartmentss NA 95% Rat Human +DTXSID3045988 Css NA 0.009436 mg/L PBTK NA 50% Rat Human +DTXSID3045988 Css NA 0.04412 mg/L PBTK NA 95% Rat Human +DTXSID3046083 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3046083 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3046083 Vd NA 3.034 L/kg 1compartment NA NA Human Human -DTXSID3046083 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID3046083 TK.Half.Life NA 61.83 hours 1compartment NA NA Human Human -DTXSID3046083 Css NA 2.577 mg/L 3compartmentss NA 50% Human Human -DTXSID3046083 Css NA 16.62 mg/L 3compartmentss NA 95% Human Human -DTXSID3046083 Css NA 1.781 mg/L PBTK NA 50% Human Human -DTXSID3046083 Css NA 11.13 mg/L PBTK NA 95% Human Human -DTXSID3046083 Clint NA 27.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3046083 Vd NA 3.057 L/kg 1compartment NA NA Human Human +DTXSID3046083 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID3046083 TK.Half.Life NA 80.66 hours 1compartment NA NA Human Human +DTXSID3046083 Css NA 3.212 mg/L 3compartmentss NA 50% Human Human +DTXSID3046083 Css NA 21.11 mg/L 3compartmentss NA 95% Human Human +DTXSID3046083 Css NA 2.21 mg/L PBTK NA 50% Human Human +DTXSID3046083 Css NA 14.07 mg/L PBTK NA 95% Human Human +DTXSID3046083 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3046083 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3046083 Vd NA 2.276 L/kg 1compartment NA NA Rat Human -DTXSID3046083 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID3046083 TK.Half.Life NA 9.596 hours 1compartment NA NA Rat Human -DTXSID3046083 Css NA 1.442 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046083 Css NA 7.618 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046083 Css NA 0.9492 mg/L PBTK NA 50% Rat Human -DTXSID3046083 Css NA 4.803 mg/L PBTK NA 95% Rat Human -DTXSID3046085 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046085 Fup NA 0.6284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046085 Vd NA 1.639 L/kg 1compartment NA NA Human Human +DTXSID3046083 Vd NA 2.292 L/kg 1compartment NA NA Rat Human +DTXSID3046083 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID3046083 TK.Half.Life NA 12.04 hours 1compartment NA NA Rat Human +DTXSID3046083 Css NA 0.419 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046083 Css NA 2.317 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046083 Css NA 0.2856 mg/L PBTK NA 50% Rat Human +DTXSID3046083 Css NA 1.563 mg/L PBTK NA 95% Rat Human +DTXSID3046085 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046085 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046085 Vd NA 0.8327 L/kg 1compartment NA NA Human Human DTXSID3046085 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3046085 TK.Half.Life NA 17.16 hours 1compartment NA NA Human Human -DTXSID3046085 Css NA 1.042 mg/L 3compartmentss NA 50% Human Human -DTXSID3046085 Css NA 7.638 mg/L 3compartmentss NA 95% Human Human -DTXSID3046085 Css NA 0.97 mg/L PBTK NA 50% Human Human -DTXSID3046085 Css NA 5.034 mg/L PBTK NA 95% Human Human -DTXSID3046085 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046085 Fup NA 0.6284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046085 Vd NA 1.636 L/kg 1compartment NA NA Rat Human +DTXSID3046085 TK.Half.Life NA 15.45 hours 1compartment NA NA Human Human +DTXSID3046085 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human +DTXSID3046085 Css NA 4.993 mg/L 3compartmentss NA 95% Human Human +DTXSID3046085 Css NA 0.813 mg/L PBTK NA 50% Human Human +DTXSID3046085 Css NA 3.249 mg/L PBTK NA 95% Human Human +DTXSID3046085 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046085 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046085 Vd NA 0.8361 L/kg 1compartment NA NA Rat Human DTXSID3046085 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046085 TK.Half.Life NA 5.762 hours 1compartment NA NA Rat Human -DTXSID3046085 Css NA 0.2697 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046085 Css NA 1.882 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046085 Css NA 0.2441 mg/L PBTK NA 50% Rat Human -DTXSID3046085 Css NA 1.161 mg/L PBTK NA 95% Rat Human -DTXSID3046110 Clint NA 51.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046110 Fup NA 0.1918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046110 Vd NA 0.9998 L/kg 1compartment NA NA Human Human +DTXSID3046085 TK.Half.Life NA 5.283 hours 1compartment NA NA Rat Human +DTXSID3046085 Css NA 0.005802 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046085 Css NA 0.02637 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046085 Css NA 0.004193 mg/L PBTK NA 50% Rat Human +DTXSID3046085 Css NA 0.01666 mg/L PBTK NA 95% Rat Human +DTXSID3046110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046110 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046110 Vd NA 0.9368 L/kg 1compartment NA NA Human Human DTXSID3046110 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046110 TK.Half.Life NA 1.186 hours 1compartment NA NA Human Human -DTXSID3046110 Css NA 0.05125 mg/L 3compartmentss NA 50% Human Human -DTXSID3046110 Css NA 0.3737 mg/L 3compartmentss NA 95% Human Human -DTXSID3046110 Css NA 0.03581 mg/L PBTK NA 50% Human Human -DTXSID3046110 Css NA 0.2481 mg/L PBTK NA 95% Human Human -DTXSID3046110 Clint NA 51.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046110 Fup NA 0.1918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046110 Vd NA 0.8233 L/kg 1compartment NA NA Rat Human +DTXSID3046110 TK.Half.Life NA 2.07 hours 1compartment NA NA Human Human +DTXSID3046110 Css NA 0.212 mg/L 3compartmentss NA 50% Human Human +DTXSID3046110 Css NA 1.668 mg/L 3compartmentss NA 95% Human Human +DTXSID3046110 Css NA 0.1385 mg/L PBTK NA 50% Human Human +DTXSID3046110 Css NA 1.035 mg/L PBTK NA 95% Human Human +DTXSID3046110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046110 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046110 Vd NA 0.7541 L/kg 1compartment NA NA Rat Human DTXSID3046110 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046110 TK.Half.Life NA 0.4868 hours 1compartment NA NA Rat Human -DTXSID3046110 Css NA 0.02835 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046110 Css NA 0.1638 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046110 Css NA 0.01886 mg/L PBTK NA 50% Rat Human -DTXSID3046110 Css NA 0.1038 mg/L PBTK NA 95% Rat Human -DTXSID3046112 Clint NA 2.735 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046112 Fup NA 0.3294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046112 Vd NA 1.574 L/kg 1compartment NA NA Human Human +DTXSID3046110 TK.Half.Life NA 0.9209 hours 1compartment NA NA Rat Human +DTXSID3046110 Css NA 0.02722 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046110 Css NA 0.1719 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046110 Css NA 0.0175 mg/L PBTK NA 50% Rat Human +DTXSID3046110 Css NA 0.1033 mg/L PBTK NA 95% Rat Human +DTXSID3046112 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046112 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046112 Vd NA 0.6741 L/kg 1compartment NA NA Human Human DTXSID3046112 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046112 TK.Half.Life NA 7.646 hours 1compartment NA NA Human Human -DTXSID3046112 Css NA 0.4906 mg/L 3compartmentss NA 50% Human Human -DTXSID3046112 Css NA 2.41 mg/L 3compartmentss NA 95% Human Human -DTXSID3046112 Css NA 0.3818 mg/L PBTK NA 50% Human Human -DTXSID3046112 Css NA 1.668 mg/L PBTK NA 95% Human Human -DTXSID3046112 Clint NA 2.735 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046112 Fup NA 0.3294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046112 Vd NA 1.274 L/kg 1compartment NA NA Rat Human +DTXSID3046112 TK.Half.Life NA 3.293 hours 1compartment NA NA Human Human +DTXSID3046112 Css NA 0.6166 mg/L 3compartmentss NA 50% Human Human +DTXSID3046112 Css NA 4.448 mg/L 3compartmentss NA 95% Human Human +DTXSID3046112 Css NA 0.4039 mg/L PBTK NA 50% Human Human +DTXSID3046112 Css NA 2.741 mg/L PBTK NA 95% Human Human +DTXSID3046112 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046112 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046112 Vd NA 0.5727 L/kg 1compartment NA NA Rat Human DTXSID3046112 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046112 TK.Half.Life NA 2.901 hours 1compartment NA NA Rat Human -DTXSID3046112 Css NA 0.2286 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046112 Css NA 0.903 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046112 Css NA 0.1704 mg/L PBTK NA 50% Rat Human -DTXSID3046112 Css NA 0.579 mg/L PBTK NA 95% Rat Human -DTXSID3046114 Clint NA 5.139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046114 Fup NA 0.1856 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046114 Vd NA 1.383 L/kg 1compartment NA NA Human Human +DTXSID3046112 TK.Half.Life NA 1.639 hours 1compartment NA NA Rat Human +DTXSID3046112 Css NA 0.07601 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046112 Css NA 0.3935 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046112 Css NA 0.04831 mg/L PBTK NA 50% Rat Human +DTXSID3046112 Css NA 0.2332 mg/L PBTK NA 95% Rat Human +DTXSID3046114 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046114 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046114 Vd NA 0.8776 L/kg 1compartment NA NA Human Human DTXSID3046114 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046114 TK.Half.Life NA 6.756 hours 1compartment NA NA Human Human -DTXSID3046114 Css NA 0.5293 mg/L 3compartmentss NA 50% Human Human -DTXSID3046114 Css NA 2.862 mg/L 3compartmentss NA 95% Human Human -DTXSID3046114 Css NA 0.3735 mg/L PBTK NA 50% Human Human -DTXSID3046114 Css NA 1.907 mg/L PBTK NA 95% Human Human -DTXSID3046114 Clint NA 5.139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046114 Fup NA 0.1856 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046114 Vd NA 1.094 L/kg 1compartment NA NA Rat Human +DTXSID3046114 TK.Half.Life NA 3.349 hours 1compartment NA NA Human Human +DTXSID3046114 Css NA 0.3817 mg/L 3compartmentss NA 50% Human Human +DTXSID3046114 Css NA 2.304 mg/L 3compartmentss NA 95% Human Human +DTXSID3046114 Css NA 0.2638 mg/L PBTK NA 50% Human Human +DTXSID3046114 Css NA 1.472 mg/L PBTK NA 95% Human Human +DTXSID3046114 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046114 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046114 Vd NA 0.7349 L/kg 1compartment NA NA Rat Human DTXSID3046114 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046114 TK.Half.Life NA 2.732 hours 1compartment NA NA Rat Human -DTXSID3046114 Css NA 0.272 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046114 Css NA 1.071 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046114 Css NA 0.183 mg/L PBTK NA 50% Rat Human -DTXSID3046114 Css NA 0.6499 mg/L PBTK NA 95% Rat Human -DTXSID3046116 Clint NA 8.081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046116 Fup NA 0.061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046116 Vd NA 0.2508 L/kg 1compartment NA NA Human Human -DTXSID3046116 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046116 TK.Half.Life NA 2.027 hours 1compartment NA NA Human Human -DTXSID3046116 Css NA 1.35 mg/L 3compartmentss NA 50% Human Human -DTXSID3046116 Css NA 9.614 mg/L 3compartmentss NA 95% Human Human -DTXSID3046116 Css NA 0.8116 mg/L PBTK NA 50% Human Human -DTXSID3046116 Css NA 5.593 mg/L PBTK NA 95% Human Human -DTXSID3046116 Clint NA 8.081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046116 Fup NA 0.061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046116 Vd NA 0.2499 L/kg 1compartment NA NA Rat Human +DTXSID3046114 TK.Half.Life NA 1.585 hours 1compartment NA NA Rat Human +DTXSID3046114 Css NA 0.04571 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046114 Css NA 0.1969 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046114 Css NA 0.03112 mg/L PBTK NA 50% Rat Human +DTXSID3046114 Css NA 0.1251 mg/L PBTK NA 95% Rat Human +DTXSID3046116 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046116 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046116 Vd NA 0.3113 L/kg 1compartment NA NA Human Human +DTXSID3046116 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3046116 TK.Half.Life NA 16.24 hours 1compartment NA NA Human Human +DTXSID3046116 Css NA 4.184 mg/L 3compartmentss NA 50% Human Human +DTXSID3046116 Css NA 20.31 mg/L 3compartmentss NA 95% Human Human +DTXSID3046116 Css NA 2.633 mg/L PBTK NA 50% Human Human +DTXSID3046116 Css NA 12.09 mg/L PBTK NA 95% Human Human +DTXSID3046116 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046116 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046116 Vd NA 0.3131 L/kg 1compartment NA NA Rat Human DTXSID3046116 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046116 TK.Half.Life NA 1.266 hours 1compartment NA NA Rat Human -DTXSID3046116 Css NA 0.7394 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046116 Css NA 3.918 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046116 Css NA 0.416 mg/L PBTK NA 50% Rat Human -DTXSID3046116 Css NA 2.159 mg/L PBTK NA 95% Rat Human -DTXSID3046118 Clint NA 15.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046118 Fup NA 0.0179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046118 Vd NA 0.2037 L/kg 1compartment NA NA Human Human +DTXSID3046116 TK.Half.Life NA 5.567 hours 1compartment NA NA Rat Human +DTXSID3046116 Css NA 0.02324 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046116 Css NA 0.1111 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046116 Css NA 0.01374 mg/L PBTK NA 50% Rat Human +DTXSID3046116 Css NA 0.06214 mg/L PBTK NA 95% Rat Human +DTXSID3046118 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046118 Fup 0.0775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046118 Vd NA 0.352 L/kg 1compartment NA NA Human Human DTXSID3046118 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046118 TK.Half.Life NA 2.985 hours 1compartment NA NA Human Human -DTXSID3046118 Css NA 2.66 mg/L 3compartmentss NA 50% Human Human -DTXSID3046118 Css NA 24.85 mg/L 3compartmentss NA 95% Human Human -DTXSID3046118 Css NA 1.56 mg/L PBTK NA 50% Human Human -DTXSID3046118 Css NA 14.59 mg/L PBTK NA 95% Human Human -DTXSID3046118 Clint NA 15.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046118 Fup NA 0.0179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046118 Vd NA 0.1958 L/kg 1compartment NA NA Rat Human +DTXSID3046118 TK.Half.Life NA 1.086 hours 1compartment NA NA Human Human +DTXSID3046118 Css NA 0.3769 mg/L 3compartmentss NA 50% Human Human +DTXSID3046118 Css NA 2.905 mg/L 3compartmentss NA 95% Human Human +DTXSID3046118 Css NA 0.2347 mg/L PBTK NA 50% Human Human +DTXSID3046118 Css NA 1.74 mg/L PBTK NA 95% Human Human +DTXSID3046118 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046118 Fup 0.0775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046118 Vd NA 0.3272 L/kg 1compartment NA NA Rat Human DTXSID3046118 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046118 TK.Half.Life NA 1.889 hours 1compartment NA NA Rat Human -DTXSID3046118 Css NA 1.462 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046118 Css NA 10.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046118 Css NA 0.8042 mg/L PBTK NA 50% Rat Human -DTXSID3046118 Css NA 5.879 mg/L PBTK NA 95% Rat Human -DTXSID3046160 Clint NA 23.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046160 Fup NA 0.028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046160 Vd NA 1.859 L/kg 1compartment NA NA Human Human -DTXSID3046160 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3046160 TK.Half.Life NA 13.65 hours 1compartment NA NA Human Human -DTXSID3046160 Css NA 1.094 mg/L 3compartmentss NA 50% Human Human -DTXSID3046160 Css NA 8.917 mg/L 3compartmentss NA 95% Human Human -DTXSID3046160 Css NA 0.6998 mg/L PBTK NA 50% Human Human -DTXSID3046160 Css NA 5.592 mg/L PBTK NA 95% Human Human -DTXSID3046160 Clint NA 23.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046160 Fup NA 0.028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046160 Vd NA 1.384 L/kg 1compartment NA NA Rat Human -DTXSID3046160 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046160 TK.Half.Life NA 4.665 hours 1compartment NA NA Rat Human -DTXSID3046160 Css NA 0.6092 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046160 Css NA 3.887 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046160 Css NA 0.3677 mg/L PBTK NA 50% Rat Human -DTXSID3046160 Css NA 2.289 mg/L PBTK NA 95% Rat Human -DTXSID3046162 Clint NA 5.217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046162 Fup NA 0.3983 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046162 Vd NA 0.3993 L/kg 1compartment NA NA Human Human +DTXSID3046118 TK.Half.Life NA 0.6129 hours 1compartment NA NA Rat Human +DTXSID3046118 Css NA 0.0492 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046118 Css NA 0.2989 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046118 Css NA 0.0297 mg/L PBTK NA 50% Rat Human +DTXSID3046118 Css NA 0.1729 mg/L PBTK NA 95% Rat Human +DTXSID3046160 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046160 Fup 0.0124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046160 Vd NA 1.88 L/kg 1compartment NA NA Human Human +DTXSID3046160 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3046160 TK.Half.Life NA 25.37 hours 1compartment NA NA Human Human +DTXSID3046160 Css NA 2.093 mg/L 3compartmentss NA 50% Human Human +DTXSID3046160 Css NA 16.98 mg/L 3compartmentss NA 95% Human Human +DTXSID3046160 Css NA 1.334 mg/L PBTK NA 50% Human Human +DTXSID3046160 Css NA 10.4 mg/L PBTK NA 95% Human Human +DTXSID3046160 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046160 Fup 0.0124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046160 Vd NA 1.392 L/kg 1compartment NA NA Rat Human +DTXSID3046160 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3046160 TK.Half.Life NA 8.546 hours 1compartment NA NA Rat Human +DTXSID3046160 Css NA 0.2705 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046160 Css NA 1.901 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046160 Css NA 0.1675 mg/L PBTK NA 50% Rat Human +DTXSID3046160 Css NA 1.139 mg/L PBTK NA 95% Rat Human +DTXSID3046162 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046162 Fup 0.707 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046162 Vd NA 0.6401 L/kg 1compartment NA NA Human Human DTXSID3046162 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046162 TK.Half.Life NA 0.9161 hours 1compartment NA NA Human Human -DTXSID3046162 Css NA 0.2075 mg/L 3compartmentss NA 50% Human Human -DTXSID3046162 Css NA 1.276 mg/L 3compartmentss NA 95% Human Human -DTXSID3046162 Css NA 0.1446 mg/L PBTK NA 50% Human Human -DTXSID3046162 Css NA 0.8233 mg/L PBTK NA 95% Human Human -DTXSID3046162 Clint NA 5.217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046162 Fup NA 0.3983 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046162 Vd NA 0.405 L/kg 1compartment NA NA Rat Human +DTXSID3046162 TK.Half.Life NA 5.864 hours 1compartment NA NA Human Human +DTXSID3046162 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human +DTXSID3046162 Css NA 6.79 mg/L 3compartmentss NA 95% Human Human +DTXSID3046162 Css NA 0.8508 mg/L PBTK NA 50% Human Human +DTXSID3046162 Css NA 4.382 mg/L PBTK NA 95% Human Human +DTXSID3046162 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046162 Fup 0.707 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046162 Vd NA 0.6436 L/kg 1compartment NA NA Rat Human DTXSID3046162 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046162 TK.Half.Life NA 0.5177 hours 1compartment NA NA Rat Human -DTXSID3046162 Css NA 0.1044 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046162 Css NA 0.4903 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046162 Css NA 0.06967 mg/L PBTK NA 50% Rat Human -DTXSID3046162 Css NA 0.2907 mg/L PBTK NA 95% Rat Human -DTXSID3046164 Clint NA 7.677 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046164 Fup NA 0.1269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046164 Vd NA 1.41 L/kg 1compartment NA NA Human Human +DTXSID3046162 TK.Half.Life NA 2.008 hours 1compartment NA NA Rat Human +DTXSID3046162 Css NA 0.06243 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046162 Css NA 0.4067 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046162 Css NA 0.051 mg/L PBTK NA 50% Rat Human +DTXSID3046162 Css NA 0.249 mg/L PBTK NA 95% Rat Human +DTXSID3046164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046164 Fup 0.384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046164 Vd NA 2.189 L/kg 1compartment NA NA Human Human DTXSID3046164 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046164 TK.Half.Life NA 6.991 hours 1compartment NA NA Human Human -DTXSID3046164 Css NA 0.6331 mg/L 3compartmentss NA 50% Human Human -DTXSID3046164 Css NA 4.182 mg/L 3compartmentss NA 95% Human Human -DTXSID3046164 Css NA 0.4306 mg/L PBTK NA 50% Human Human -DTXSID3046164 Css NA 2.612 mg/L PBTK NA 95% Human Human -DTXSID3046164 Clint NA 7.677 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046164 Fup NA 0.1269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046164 Vd NA 1.108 L/kg 1compartment NA NA Rat Human +DTXSID3046164 TK.Half.Life NA 2.998 hours 1compartment NA NA Human Human +DTXSID3046164 Css NA 0.07672 mg/L 3compartmentss NA 50% Human Human +DTXSID3046164 Css NA 0.5543 mg/L 3compartmentss NA 95% Human Human +DTXSID3046164 Css NA 0.06132 mg/L PBTK NA 50% Human Human +DTXSID3046164 Css NA 0.3983 mg/L PBTK NA 95% Human Human +DTXSID3046164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046164 Fup 0.384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046164 Vd NA 1.751 L/kg 1compartment NA NA Rat Human DTXSID3046164 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046164 TK.Half.Life NA 2.864 hours 1compartment NA NA Rat Human -DTXSID3046164 Css NA 0.3375 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046164 Css NA 1.661 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046164 Css NA 0.2176 mg/L PBTK NA 50% Rat Human -DTXSID3046164 Css NA 0.9689 mg/L PBTK NA 95% Rat Human -DTXSID3046166 Clint NA 62.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046166 Fup NA 0.9461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046166 Vd NA 2.148 L/kg 1compartment NA NA Human Human +DTXSID3046164 TK.Half.Life NA 1.041 hours 1compartment NA NA Rat Human +DTXSID3046164 Css NA 0.009422 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046164 Css NA 0.05371 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046164 Css NA 0.007586 mg/L PBTK NA 50% Rat Human +DTXSID3046164 Css NA 0.03884 mg/L PBTK NA 95% Rat Human +DTXSID3046166 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046166 Fup 0.61 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046166 Vd NA 0.8374 L/kg 1compartment NA NA Human Human DTXSID3046166 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046166 TK.Half.Life NA 1.054 hours 1compartment NA NA Human Human -DTXSID3046166 Css NA 0.007466 mg/L 3compartmentss NA 50% Human Human -DTXSID3046166 Css NA 0.08147 mg/L 3compartmentss NA 95% Human Human -DTXSID3046166 Css NA 0.007697 mg/L PBTK NA 50% Human Human -DTXSID3046166 Css NA 0.06762 mg/L PBTK NA 95% Human Human -DTXSID3046166 Clint NA 62.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046166 Fup NA 0.9461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046166 Vd NA 2.161 L/kg 1compartment NA NA Rat Human +DTXSID3046166 TK.Half.Life NA 9.029 hours 1compartment NA NA Human Human +DTXSID3046166 Css NA 1.158 mg/L 3compartmentss NA 50% Human Human +DTXSID3046166 Css NA 8.193 mg/L 3compartmentss NA 95% Human Human +DTXSID3046166 Css NA 0.9502 mg/L PBTK NA 50% Human Human +DTXSID3046166 Css NA 5.16 mg/L PBTK NA 95% Human Human +DTXSID3046166 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046166 Fup 0.61 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046166 Vd NA 0.8158 L/kg 1compartment NA NA Rat Human DTXSID3046166 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046166 TK.Half.Life NA 0.4864 hours 1compartment NA NA Rat Human -DTXSID3046166 Css NA 0.003667 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046166 Css NA 0.03851 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046166 Css NA 0.003843 mg/L PBTK NA 50% Rat Human -DTXSID3046166 Css NA 0.03206 mg/L PBTK NA 95% Rat Human -DTXSID3046241 Clint NA 52.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046241 Fup NA 0.1078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046241 Vd NA 4.271 L/kg 1compartment NA NA Human Human -DTXSID3046241 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046241 TK.Half.Life NA 1.949 hours 1compartment NA NA Human Human -DTXSID3046241 Css NA 0.003124 mg/L 3compartmentss NA 50% Human Human -DTXSID3046241 Css NA 0.02901 mg/L 3compartmentss NA 95% Human Human -DTXSID3046241 Css NA 0.00374 mg/L PBTK NA 50% Human Human -DTXSID3046241 Css NA 0.02824 mg/L PBTK NA 95% Human Human -DTXSID3046241 Clint NA 52.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046241 Fup NA 0.1078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046241 Vd NA 3.961 L/kg 1compartment NA NA Rat Human -DTXSID3046241 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046241 TK.Half.Life NA 0.7933 hours 1compartment NA NA Rat Human -DTXSID3046241 Css NA 0.001688 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046241 Css NA 0.01254 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046241 Css NA 0.002031 mg/L PBTK NA 50% Rat Human -DTXSID3046241 Css NA 0.01209 mg/L PBTK NA 95% Rat Human -DTXSID3046245 Clint NA 26.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046245 Fup NA 0.0921 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046245 Vd NA 2.51 L/kg 1compartment NA NA Human Human +DTXSID3046166 TK.Half.Life NA 2.961 hours 1compartment NA NA Rat Human +DTXSID3046166 Css NA 0.06998 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046166 Css NA 0.459 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046166 Css NA 0.05752 mg/L PBTK NA 50% Rat Human +DTXSID3046166 Css NA 0.2808 mg/L PBTK NA 95% Rat Human +DTXSID3046245 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046245 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046245 Vd NA 2.698 L/kg 1compartment NA NA Human Human DTXSID3046245 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046245 TK.Half.Life NA 9.976 hours 1compartment NA NA Human Human -DTXSID3046245 Css NA 0.4511 mg/L 3compartmentss NA 50% Human Human -DTXSID3046245 Css NA 3.108 mg/L 3compartmentss NA 95% Human Human -DTXSID3046245 Css NA 0.3073 mg/L PBTK NA 50% Human Human -DTXSID3046245 Css NA 2.048 mg/L PBTK NA 95% Human Human -DTXSID3046245 Clint NA 26.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046245 Fup NA 0.0921 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046245 Vd NA 1.892 L/kg 1compartment NA NA Rat Human +DTXSID3046245 TK.Half.Life NA 11.4 hours 1compartment NA NA Human Human +DTXSID3046245 Css NA 0.4412 mg/L 3compartmentss NA 50% Human Human +DTXSID3046245 Css NA 2.895 mg/L 3compartmentss NA 95% Human Human +DTXSID3046245 Css NA 0.3099 mg/L PBTK NA 50% Human Human +DTXSID3046245 Css NA 1.954 mg/L PBTK NA 95% Human Human +DTXSID3046245 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046245 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046245 Vd NA 2.039 L/kg 1compartment NA NA Rat Human DTXSID3046245 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046245 TK.Half.Life NA 2.63 hours 1compartment NA NA Rat Human -DTXSID3046245 Css NA 0.248 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046245 Css NA 1.372 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046245 Css NA 0.1615 mg/L PBTK NA 50% Rat Human -DTXSID3046245 Css NA 0.8506 mg/L PBTK NA 95% Rat Human -DTXSID3046247 Clint NA 47.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046247 Fup NA 0.0537 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046247 Vd NA 2.074 L/kg 1compartment NA NA Human Human +DTXSID3046245 TK.Half.Life NA 2.694 hours 1compartment NA NA Rat Human +DTXSID3046245 Css NA 0.05667 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046245 Css NA 0.2897 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046245 Css NA 0.03928 mg/L PBTK NA 50% Rat Human +DTXSID3046245 Css NA 0.1948 mg/L PBTK NA 95% Rat Human +DTXSID3046247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046247 Fup 0.0379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046247 Vd NA 1.664 L/kg 1compartment NA NA Human Human DTXSID3046247 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046247 TK.Half.Life NA 6.075 hours 1compartment NA NA Human Human -DTXSID3046247 Css NA 0.3273 mg/L 3compartmentss NA 50% Human Human -DTXSID3046247 Css NA 2.373 mg/L 3compartmentss NA 95% Human Human -DTXSID3046247 Css NA 0.2164 mg/L PBTK NA 50% Human Human -DTXSID3046247 Css NA 1.48 mg/L PBTK NA 95% Human Human -DTXSID3046247 Clint NA 47.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046247 Fup NA 0.0537 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046247 Vd NA 1.555 L/kg 1compartment NA NA Rat Human +DTXSID3046247 TK.Half.Life NA 9.943 hours 1compartment NA NA Human Human +DTXSID3046247 Css NA 0.8592 mg/L 3compartmentss NA 50% Human Human +DTXSID3046247 Css NA 6.899 mg/L 3compartmentss NA 95% Human Human +DTXSID3046247 Css NA 0.5491 mg/L PBTK NA 50% Human Human +DTXSID3046247 Css NA 4.255 mg/L PBTK NA 95% Human Human +DTXSID3046247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046247 Fup 0.0379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046247 Vd NA 1.244 L/kg 1compartment NA NA Rat Human DTXSID3046247 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046247 TK.Half.Life NA 1.949 hours 1compartment NA NA Rat Human -DTXSID3046247 Css NA 0.1842 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046247 Css NA 1.096 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046247 Css NA 0.1148 mg/L PBTK NA 50% Rat Human -DTXSID3046247 Css NA 0.6472 mg/L PBTK NA 95% Rat Human -DTXSID3046249 Clint NA 8.242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046249 Fup NA 0.0438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046249 Vd NA 1.647 L/kg 1compartment NA NA Human Human -DTXSID3046249 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3046249 TK.Half.Life NA 20.24 hours 1compartment NA NA Human Human -DTXSID3046249 Css NA 1.89 mg/L 3compartmentss NA 50% Human Human -DTXSID3046249 Css NA 13.44 mg/L 3compartmentss NA 95% Human Human -DTXSID3046249 Css NA 1.218 mg/L PBTK NA 50% Human Human -DTXSID3046249 Css NA 8.228 mg/L PBTK NA 95% Human Human -DTXSID3046249 Clint NA 8.242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046249 Fup NA 0.0438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046249 Vd NA 1.234 L/kg 1compartment NA NA Rat Human -DTXSID3046249 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3046249 TK.Half.Life NA 7.348 hours 1compartment NA NA Rat Human -DTXSID3046249 Css NA 1.038 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046249 Css NA 5.629 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046249 Css NA 0.6272 mg/L PBTK NA 50% Rat Human -DTXSID3046249 Css NA 3.203 mg/L PBTK NA 95% Rat Human -DTXSID3046291 Clint NA 1.296 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046291 Fup NA 0.0996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046291 Vd NA 0.6005 L/kg 1compartment NA NA Human Human -DTXSID3046291 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3046291 TK.Half.Life NA 12.73 hours 1compartment NA NA Human Human -DTXSID3046291 Css NA 3.237 mg/L 3compartmentss NA 50% Human Human -DTXSID3046291 Css NA 17.75 mg/L 3compartmentss NA 95% Human Human -DTXSID3046291 Css NA 2.052 mg/L PBTK NA 50% Human Human -DTXSID3046291 Css NA 10.56 mg/L PBTK NA 95% Human Human -DTXSID3046291 Clint NA 1.296 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046291 Fup NA 0.0996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046291 Vd NA 0.4922 L/kg 1compartment NA NA Rat Human +DTXSID3046247 TK.Half.Life NA 3.646 hours 1compartment NA NA Rat Human +DTXSID3046247 Css NA 0.1104 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046247 Css NA 0.7144 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046247 Css NA 0.06902 mg/L PBTK NA 50% Rat Human +DTXSID3046247 Css NA 0.4254 mg/L PBTK NA 95% Rat Human +DTXSID3046291 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046291 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046291 Vd NA 0.6632 L/kg 1compartment NA NA Human Human +DTXSID3046291 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3046291 TK.Half.Life NA 1.506 hours 1compartment NA NA Human Human +DTXSID3046291 Css NA 0.1943 mg/L 3compartmentss NA 50% Human Human +DTXSID3046291 Css NA 1.638 mg/L 3compartmentss NA 95% Human Human +DTXSID3046291 Css NA 0.1246 mg/L PBTK NA 50% Human Human +DTXSID3046291 Css NA 0.984 mg/L PBTK NA 95% Human Human +DTXSID3046291 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046291 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046291 Vd NA 0.5434 L/kg 1compartment NA NA Rat Human DTXSID3046291 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046291 TK.Half.Life NA 5.295 hours 1compartment NA NA Rat Human -DTXSID3046291 Css NA 1.441 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046291 Css NA 6.121 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046291 Css NA 0.8528 mg/L PBTK NA 50% Rat Human -DTXSID3046291 Css NA 3.388 mg/L PBTK NA 95% Rat Human -DTXSID3046295 Clint NA 39.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046295 Fup NA 0.0714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046295 Vd NA 1.541 L/kg 1compartment NA NA Human Human +DTXSID3046291 TK.Half.Life NA 0.7013 hours 1compartment NA NA Rat Human +DTXSID3046291 Css NA 0.009458 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046291 Css NA 0.08546 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046291 Css NA 0.005868 mg/L PBTK NA 50% Rat Human +DTXSID3046291 Css NA 0.05057 mg/L PBTK NA 95% Rat Human +DTXSID3046295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046295 Fup 0.199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046295 Vd NA 3.173 L/kg 1compartment NA NA Human Human DTXSID3046295 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046295 TK.Half.Life NA 2.822 hours 1compartment NA NA Human Human -DTXSID3046295 Css NA 0.1497 mg/L 3compartmentss NA 50% Human Human -DTXSID3046295 Css NA 1.239 mg/L 3compartmentss NA 95% Human Human -DTXSID3046295 Css NA 0.1106 mg/L PBTK NA 50% Human Human -DTXSID3046295 Css NA 0.8269 mg/L PBTK NA 95% Human Human -DTXSID3046295 Clint NA 39.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046295 Fup NA 0.0714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046295 Vd NA 1.51 L/kg 1compartment NA NA Rat Human +DTXSID3046295 TK.Half.Life NA 3.936 hours 1compartment NA NA Human Human +DTXSID3046295 Css NA 0.05994 mg/L 3compartmentss NA 50% Human Human +DTXSID3046295 Css NA 0.5291 mg/L 3compartmentss NA 95% Human Human +DTXSID3046295 Css NA 0.06264 mg/L PBTK NA 50% Human Human +DTXSID3046295 Css NA 0.4524 mg/L PBTK NA 95% Human Human +DTXSID3046295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046295 Fup 0.199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046295 Vd NA 3.16 L/kg 1compartment NA NA Rat Human DTXSID3046295 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046295 TK.Half.Life NA 1.603 hours 1compartment NA NA Rat Human -DTXSID3046295 Css NA 0.08564 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046295 Css NA 0.5293 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046295 Css NA 0.05973 mg/L PBTK NA 50% Rat Human -DTXSID3046295 Css NA 0.3375 mg/L PBTK NA 95% Rat Human -DTXSID3046297 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046297 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046297 Vd NA 0.3501 L/kg 1compartment NA NA Human Human +DTXSID3046295 TK.Half.Life NA 2.171 hours 1compartment NA NA Rat Human +DTXSID3046295 Css NA 0.007406 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046295 Css NA 0.04652 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046295 Css NA 0.007964 mg/L PBTK NA 50% Rat Human +DTXSID3046295 Css NA 0.04112 mg/L PBTK NA 95% Rat Human +DTXSID3046297 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046297 Fup 0.0769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046297 Vd NA 0.8411 L/kg 1compartment NA NA Human Human DTXSID3046297 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046297 TK.Half.Life NA 4.687 hours 1compartment NA NA Human Human -DTXSID3046297 Css NA 2.238 mg/L 3compartmentss NA 50% Human Human -DTXSID3046297 Css NA 13.85 mg/L 3compartmentss NA 95% Human Human -DTXSID3046297 Css NA 1.359 mg/L PBTK NA 50% Human Human -DTXSID3046297 Css NA 8.121 mg/L PBTK NA 95% Human Human -DTXSID3046297 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046297 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046297 Vd NA 0.3155 L/kg 1compartment NA NA Rat Human +DTXSID3046297 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human +DTXSID3046297 Css NA 1.07 mg/L 3compartmentss NA 50% Human Human +DTXSID3046297 Css NA 7.109 mg/L 3compartmentss NA 95% Human Human +DTXSID3046297 Css NA 0.6792 mg/L PBTK NA 50% Human Human +DTXSID3046297 Css NA 4.266 mg/L PBTK NA 95% Human Human +DTXSID3046297 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046297 Fup 0.0769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046297 Vd NA 0.6617 L/kg 1compartment NA NA Rat Human DTXSID3046297 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046297 TK.Half.Life NA 2.543 hours 1compartment NA NA Rat Human -DTXSID3046297 Css NA 1.148 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046297 Css NA 5.171 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046297 Css NA 0.651 mg/L PBTK NA 50% Rat Human -DTXSID3046297 Css NA 2.839 mg/L PBTK NA 95% Rat Human -DTXSID3046299 Clint NA 60.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046299 Fup NA 0.2192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046299 Vd NA 1.668 L/kg 1compartment NA NA Human Human +DTXSID3046297 TK.Half.Life NA 3.155 hours 1compartment NA NA Rat Human +DTXSID3046297 Css NA 0.04966 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046297 Css NA 0.3645 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046297 Css NA 0.0302 mg/L PBTK NA 50% Rat Human +DTXSID3046297 Css NA 0.2114 mg/L PBTK NA 95% Rat Human +DTXSID3046299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046299 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046299 Vd NA 1.589 L/kg 1compartment NA NA Human Human DTXSID3046299 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046299 TK.Half.Life NA 1.86 hours 1compartment NA NA Human Human -DTXSID3046299 Css NA 0.04531 mg/L 3compartmentss NA 50% Human Human -DTXSID3046299 Css NA 0.2988 mg/L 3compartmentss NA 95% Human Human -DTXSID3046299 Css NA 0.03297 mg/L PBTK NA 50% Human Human -DTXSID3046299 Css NA 0.2034 mg/L PBTK NA 95% Human Human -DTXSID3046299 Clint NA 60.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046299 Fup NA 0.2192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046299 Vd NA 1.308 L/kg 1compartment NA NA Rat Human +DTXSID3046299 TK.Half.Life NA 2.914 hours 1compartment NA NA Human Human +DTXSID3046299 Css NA 0.1291 mg/L 3compartmentss NA 50% Human Human +DTXSID3046299 Css NA 0.9375 mg/L 3compartmentss NA 95% Human Human +DTXSID3046299 Css NA 0.09266 mg/L PBTK NA 50% Human Human +DTXSID3046299 Css NA 0.6263 mg/L PBTK NA 95% Human Human +DTXSID3046299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046299 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046299 Vd NA 1.246 L/kg 1compartment NA NA Rat Human DTXSID3046299 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046299 TK.Half.Life NA 0.6743 hours 1compartment NA NA Rat Human -DTXSID3046299 Css NA 0.02486 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046299 Css NA 0.1363 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046299 Css NA 0.01744 mg/L PBTK NA 50% Rat Human -DTXSID3046299 Css NA 0.09088 mg/L PBTK NA 95% Rat Human -DTXSID3046320 Clint NA 10.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046320 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046320 Vd NA 0.4255 L/kg 1compartment NA NA Human Human +DTXSID3046299 TK.Half.Life NA 1.116 hours 1compartment NA NA Rat Human +DTXSID3046299 Css NA 0.01639 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046299 Css NA 0.08303 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046299 Css NA 0.01168 mg/L PBTK NA 50% Rat Human +DTXSID3046299 Css NA 0.05561 mg/L PBTK NA 95% Rat Human +DTXSID3046320 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046320 Fup 0.442 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046320 Vd NA 1.075 L/kg 1compartment NA NA Human Human DTXSID3046320 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046320 TK.Half.Life NA 2.379 hours 1compartment NA NA Human Human -DTXSID3046320 Css NA 0.8336 mg/L 3compartmentss NA 50% Human Human -DTXSID3046320 Css NA 6.083 mg/L 3compartmentss NA 95% Human Human -DTXSID3046320 Css NA 0.5126 mg/L PBTK NA 50% Human Human -DTXSID3046320 Css NA 3.588 mg/L PBTK NA 95% Human Human -DTXSID3046320 Clint NA 10.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046320 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046320 Vd NA 0.4103 L/kg 1compartment NA NA Rat Human +DTXSID3046320 TK.Half.Life NA 2.068 hours 1compartment NA NA Human Human +DTXSID3046320 Css NA 0.1464 mg/L 3compartmentss NA 50% Human Human +DTXSID3046320 Css NA 0.9732 mg/L 3compartmentss NA 95% Human Human +DTXSID3046320 Css NA 0.1147 mg/L PBTK NA 50% Human Human +DTXSID3046320 Css NA 0.6708 mg/L PBTK NA 95% Human Human +DTXSID3046320 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046320 Fup 0.442 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046320 Vd NA 0.9464 L/kg 1compartment NA NA Rat Human DTXSID3046320 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046320 TK.Half.Life NA 1.428 hours 1compartment NA NA Rat Human -DTXSID3046320 Css NA 0.4584 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046320 Css NA 2.455 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046320 Css NA 0.2649 mg/L PBTK NA 50% Rat Human -DTXSID3046320 Css NA 1.371 mg/L PBTK NA 95% Rat Human -DTXSID3046322 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046322 Fup NA 0.1282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046322 Vd NA 2.103 L/kg 1compartment NA NA Human Human +DTXSID3046320 TK.Half.Life NA 0.9735 hours 1compartment NA NA Rat Human +DTXSID3046320 Css NA 0.01699 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046320 Css NA 0.09108 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046320 Css NA 0.01354 mg/L PBTK NA 50% Rat Human +DTXSID3046320 Css NA 0.06097 mg/L PBTK NA 95% Rat Human +DTXSID3046322 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046322 Fup 0.0934 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046322 Vd NA 2.136 L/kg 1compartment NA NA Human Human DTXSID3046322 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046322 TK.Half.Life NA 4.201 hours 1compartment NA NA Human Human -DTXSID3046322 Css NA 0.1748 mg/L 3compartmentss NA 50% Human Human -DTXSID3046322 Css NA 1.286 mg/L 3compartmentss NA 95% Human Human -DTXSID3046322 Css NA 0.1206 mg/L PBTK NA 50% Human Human -DTXSID3046322 Css NA 0.8379 mg/L PBTK NA 95% Human Human -DTXSID3046322 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046322 Fup NA 0.1282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046322 Vd NA 1.604 L/kg 1compartment NA NA Rat Human +DTXSID3046322 TK.Half.Life NA 7.842 hours 1compartment NA NA Human Human +DTXSID3046322 Css NA 0.3548 mg/L 3compartmentss NA 50% Human Human +DTXSID3046322 Css NA 2.665 mg/L 3compartmentss NA 95% Human Human +DTXSID3046322 Css NA 0.2412 mg/L PBTK NA 50% Human Human +DTXSID3046322 Css NA 1.731 mg/L PBTK NA 95% Human Human +DTXSID3046322 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046322 Fup 0.0934 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046322 Vd NA 1.617 L/kg 1compartment NA NA Rat Human DTXSID3046322 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046322 TK.Half.Life NA 1.378 hours 1compartment NA NA Rat Human -DTXSID3046322 Css NA 0.09598 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046322 Css NA 0.5486 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046322 Css NA 0.06335 mg/L PBTK NA 50% Rat Human -DTXSID3046322 Css NA 0.3438 mg/L PBTK NA 95% Rat Human -DTXSID3046324 Clint NA 1.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046324 Fup NA 0.1453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046324 Vd NA 0.7531 L/kg 1compartment NA NA Human Human +DTXSID3046322 TK.Half.Life NA 2.478 hours 1compartment NA NA Rat Human +DTXSID3046322 Css NA 0.01781 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046322 Css NA 0.143 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046322 Css NA 0.01188 mg/L PBTK NA 50% Rat Human +DTXSID3046322 Css NA 0.08835 mg/L PBTK NA 95% Rat Human +DTXSID3046324 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046324 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046324 Vd NA 0.7676 L/kg 1compartment NA NA Human Human DTXSID3046324 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046324 TK.Half.Life NA 8.942 hours 1compartment NA NA Human Human -DTXSID3046324 Css NA 1.662 mg/L 3compartmentss NA 50% Human Human -DTXSID3046324 Css NA 9.52 mg/L 3compartmentss NA 95% Human Human -DTXSID3046324 Css NA 1.098 mg/L PBTK NA 50% Human Human -DTXSID3046324 Css NA 5.789 mg/L PBTK NA 95% Human Human -DTXSID3046324 Clint NA 1.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046324 Fup NA 0.1453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046324 Vd NA 0.6536 L/kg 1compartment NA NA Rat Human +DTXSID3046324 TK.Half.Life NA 1.805 hours 1compartment NA NA Human Human +DTXSID3046324 Css NA 0.2009 mg/L 3compartmentss NA 50% Human Human +DTXSID3046324 Css NA 1.224 mg/L 3compartmentss NA 95% Human Human +DTXSID3046324 Css NA 0.1456 mg/L PBTK NA 50% Human Human +DTXSID3046324 Css NA 0.8124 mg/L PBTK NA 95% Human Human +DTXSID3046324 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046324 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046324 Vd NA 0.6715 L/kg 1compartment NA NA Rat Human DTXSID3046324 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046324 TK.Half.Life NA 4.099 hours 1compartment NA NA Rat Human -DTXSID3046324 Css NA 0.7511 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046324 Css NA 3.285 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046324 Css NA 0.4692 mg/L PBTK NA 50% Rat Human -DTXSID3046324 Css NA 1.853 mg/L PBTK NA 95% Rat Human -DTXSID3046326 Clint NA 50.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046326 Fup NA 0.1331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046326 Vd NA 2.88 L/kg 1compartment NA NA Human Human -DTXSID3046326 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046326 TK.Half.Life NA 7.896 hours 1compartment NA NA Human Human -DTXSID3046326 Css NA 0.2524 mg/L 3compartmentss NA 50% Human Human -DTXSID3046326 Css NA 1.642 mg/L 3compartmentss NA 95% Human Human -DTXSID3046326 Css NA 0.179 mg/L PBTK NA 50% Human Human -DTXSID3046326 Css NA 1.113 mg/L PBTK NA 95% Human Human -DTXSID3046326 Clint NA 50.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046326 Fup NA 0.1331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046326 Vd NA 2.189 L/kg 1compartment NA NA Rat Human -DTXSID3046326 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046326 TK.Half.Life NA 1.836 hours 1compartment NA NA Rat Human -DTXSID3046326 Css NA 0.141 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046326 Css NA 0.748 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046326 Css NA 0.09574 mg/L PBTK NA 50% Rat Human -DTXSID3046326 Css NA 0.489 mg/L PBTK NA 95% Rat Human -DTXSID3046401 Clint NA 7.419 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046401 Fup NA 0.1614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046401 Vd NA 1.344 L/kg 1compartment NA NA Human Human +DTXSID3046324 TK.Half.Life NA 0.8727 hours 1compartment NA NA Rat Human +DTXSID3046324 Css NA 0.02321 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046324 Css NA 0.1112 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046324 Css NA 0.01689 mg/L PBTK NA 50% Rat Human +DTXSID3046324 Css NA 0.07072 mg/L PBTK NA 95% Rat Human +DTXSID3046326 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046326 Fup 0.0969 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046326 Vd NA 2.942 L/kg 1compartment NA NA Human Human +DTXSID3046326 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3046326 TK.Half.Life NA 22.73 hours 1compartment NA NA Human Human +DTXSID3046326 Css NA 0.8668 mg/L 3compartmentss NA 50% Human Human +DTXSID3046326 Css NA 5.585 mg/L 3compartmentss NA 95% Human Human +DTXSID3046326 Css NA 0.6082 mg/L PBTK NA 50% Human Human +DTXSID3046326 Css NA 3.749 mg/L PBTK NA 95% Human Human +DTXSID3046326 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046326 Fup 0.0969 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046326 Vd NA 2.223 L/kg 1compartment NA NA Rat Human +DTXSID3046326 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3046326 TK.Half.Life NA 4.297 hours 1compartment NA NA Rat Human +DTXSID3046326 Css NA 0.1122 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046326 Css NA 0.6217 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046326 Css NA 0.07786 mg/L PBTK NA 50% Rat Human +DTXSID3046326 Css NA 0.4172 mg/L PBTK NA 95% Rat Human +DTXSID3046401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046401 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046401 Vd NA 1.137 L/kg 1compartment NA NA Human Human DTXSID3046401 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046401 TK.Half.Life NA 5.559 hours 1compartment NA NA Human Human -DTXSID3046401 Css NA 0.4689 mg/L 3compartmentss NA 50% Human Human -DTXSID3046401 Css NA 2.827 mg/L 3compartmentss NA 95% Human Human -DTXSID3046401 Css NA 0.324 mg/L PBTK NA 50% Human Human -DTXSID3046401 Css NA 1.83 mg/L PBTK NA 95% Human Human -DTXSID3046401 Clint NA 7.419 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046401 Fup NA 0.1614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046401 Vd NA 1.056 L/kg 1compartment NA NA Rat Human +DTXSID3046401 TK.Half.Life NA 2.06 hours 1compartment NA NA Human Human +DTXSID3046401 Css NA 0.128 mg/L 3compartmentss NA 50% Human Human +DTXSID3046401 Css NA 0.8864 mg/L 3compartmentss NA 95% Human Human +DTXSID3046401 Css NA 0.08896 mg/L PBTK NA 50% Human Human +DTXSID3046401 Css NA 0.5813 mg/L PBTK NA 95% Human Human +DTXSID3046401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046401 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046401 Vd NA 0.9161 L/kg 1compartment NA NA Rat Human DTXSID3046401 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046401 TK.Half.Life NA 2.282 hours 1compartment NA NA Rat Human -DTXSID3046401 Css NA 0.2427 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046401 Css NA 1.169 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046401 Css NA 0.1602 mg/L PBTK NA 50% Rat Human -DTXSID3046401 Css NA 0.71 mg/L PBTK NA 95% Rat Human -DTXSID3046403 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046403 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046403 Vd NA 0.8567 L/kg 1compartment NA NA Human Human +DTXSID3046401 TK.Half.Life NA 0.8762 hours 1compartment NA NA Rat Human +DTXSID3046401 Css NA 0.01625 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046401 Css NA 0.08452 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046401 Css NA 0.0112 mg/L PBTK NA 50% Rat Human +DTXSID3046401 Css NA 0.05509 mg/L PBTK NA 95% Rat Human +DTXSID3046403 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046403 Fup 0.513 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046403 Vd NA 0.4281 L/kg 1compartment NA NA Human Human DTXSID3046403 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046403 TK.Half.Life NA 5.559 hours 1compartment NA NA Human Human -DTXSID3046403 Css NA 0.8086 mg/L 3compartmentss NA 50% Human Human -DTXSID3046403 Css NA 5.45 mg/L 3compartmentss NA 95% Human Human -DTXSID3046403 Css NA 0.6972 mg/L PBTK NA 50% Human Human -DTXSID3046403 Css NA 3.601 mg/L PBTK NA 95% Human Human -DTXSID3046403 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046403 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046403 Vd NA 0.8803 L/kg 1compartment NA NA Rat Human +DTXSID3046403 TK.Half.Life NA 5.398 hours 1compartment NA NA Human Human +DTXSID3046403 Css NA 0.8133 mg/L 3compartmentss NA 50% Human Human +DTXSID3046403 Css NA 4.389 mg/L 3compartmentss NA 95% Human Human +DTXSID3046403 Css NA 0.5933 mg/L PBTK NA 50% Human Human +DTXSID3046403 Css NA 2.729 mg/L PBTK NA 95% Human Human +DTXSID3046403 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046403 Fup 0.513 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046403 Vd NA 0.4436 L/kg 1compartment NA NA Rat Human DTXSID3046403 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046403 TK.Half.Life NA 1.942 hours 1compartment NA NA Rat Human -DTXSID3046403 Css NA 0.204 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046403 Css NA 1.252 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046403 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID3046403 Css NA 0.7616 mg/L PBTK NA 95% Rat Human -DTXSID3046405 Clint NA 4924 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046405 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046405 Vd NA 1.054 L/kg 1compartment NA NA Human Human +DTXSID3046403 TK.Half.Life NA 1.906 hours 1compartment NA NA Rat Human +DTXSID3046403 Css NA 0.004336 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046403 Css NA 0.02437 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046403 Css NA 0.003003 mg/L PBTK NA 50% Rat Human +DTXSID3046403 Css NA 0.01443 mg/L PBTK NA 95% Rat Human +DTXSID3046405 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046405 Fup 0.0472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046405 Vd NA 1.185 L/kg 1compartment NA NA Human Human DTXSID3046405 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046405 TK.Half.Life NA 0.9694 hours 1compartment NA NA Human Human -DTXSID3046405 Css NA 0.003028 mg/L 3compartmentss NA 50% Human Human -DTXSID3046405 Css NA 0.02507 mg/L 3compartmentss NA 95% Human Human -DTXSID3046405 Css NA 0.001897 mg/L PBTK NA 50% Human Human -DTXSID3046405 Css NA 0.01518 mg/L PBTK NA 95% Human Human -DTXSID3046405 Clint NA 4924 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046405 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046405 Vd NA 0.8003 L/kg 1compartment NA NA Rat Human +DTXSID3046405 TK.Half.Life NA 5.497 hours 1compartment NA NA Human Human +DTXSID3046405 Css NA 0.6313 mg/L 3compartmentss NA 50% Human Human +DTXSID3046405 Css NA 5.021 mg/L 3compartmentss NA 95% Human Human +DTXSID3046405 Css NA 0.3979 mg/L PBTK NA 50% Human Human +DTXSID3046405 Css NA 3.066 mg/L PBTK NA 95% Human Human +DTXSID3046405 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046405 Fup 0.0472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046405 Vd NA 0.8956 L/kg 1compartment NA NA Rat Human DTXSID3046405 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046405 TK.Half.Life NA 0.3247 hours 1compartment NA NA Rat Human -DTXSID3046405 Css NA 0.001778 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046405 Css NA 0.01182 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046405 Css NA 0.001039 mg/L PBTK NA 50% Rat Human -DTXSID3046405 Css NA 0.0067 mg/L PBTK NA 95% Rat Human -DTXSID3046407 Clint NA 9.177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046407 Fup NA 0.7211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046407 Vd NA 2.019 L/kg 1compartment NA NA Human Human -DTXSID3046407 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046407 TK.Half.Life NA 2.07 hours 1compartment NA NA Human Human -DTXSID3046407 Css NA 0.06002 mg/L 3compartmentss NA 50% Human Human -DTXSID3046407 Css NA 0.5776 mg/L 3compartmentss NA 95% Human Human -DTXSID3046407 Css NA 0.05846 mg/L PBTK NA 50% Human Human -DTXSID3046407 Css NA 0.4327 mg/L PBTK NA 95% Human Human -DTXSID3046407 Clint NA 9.177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046407 Fup NA 0.7211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046407 Vd NA 1.97 L/kg 1compartment NA NA Rat Human +DTXSID3046405 TK.Half.Life NA 2.305 hours 1compartment NA NA Rat Human +DTXSID3046405 Css NA 0.08274 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046405 Css NA 0.5087 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046405 Css NA 0.05077 mg/L PBTK NA 50% Rat Human +DTXSID3046405 Css NA 0.2979 mg/L PBTK NA 95% Rat Human +DTXSID3046407 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046407 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046407 Vd NA 1.501 L/kg 1compartment NA NA Human Human +DTXSID3046407 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3046407 TK.Half.Life NA 22.29 hours 1compartment NA NA Human Human +DTXSID3046407 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human +DTXSID3046407 Css NA 6.95 mg/L 3compartmentss NA 95% Human Human +DTXSID3046407 Css NA 1.198 mg/L PBTK NA 50% Human Human +DTXSID3046407 Css NA 4.702 mg/L PBTK NA 95% Human Human +DTXSID3046407 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046407 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046407 Vd NA 1.456 L/kg 1compartment NA NA Rat Human DTXSID3046407 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046407 TK.Half.Life NA 1.054 hours 1compartment NA NA Rat Human -DTXSID3046407 Css NA 0.02863 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046407 Css NA 0.2555 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046407 Css NA 0.02816 mg/L PBTK NA 50% Rat Human -DTXSID3046407 Css NA 0.1731 mg/L PBTK NA 95% Rat Human -DTXSID3046409 Clint NA 49.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046409 Fup NA 0.1411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046409 Vd NA 0.9724 L/kg 1compartment NA NA Human Human +DTXSID3046407 TK.Half.Life NA 7.152 hours 1compartment NA NA Rat Human +DTXSID3046407 Css NA 0.08657 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046407 Css NA 0.391 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046407 Css NA 0.07581 mg/L PBTK NA 50% Rat Human +DTXSID3046407 Css NA 0.2553 mg/L PBTK NA 95% Rat Human +DTXSID3046409 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046409 Fup 0.492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046409 Vd NA 1.864 L/kg 1compartment NA NA Human Human DTXSID3046409 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046409 TK.Half.Life NA 1.305 hours 1compartment NA NA Human Human -DTXSID3046409 Css NA 0.08254 mg/L 3compartmentss NA 50% Human Human -DTXSID3046409 Css NA 0.6994 mg/L 3compartmentss NA 95% Human Human -DTXSID3046409 Css NA 0.05632 mg/L PBTK NA 50% Human Human -DTXSID3046409 Css NA 0.4455 mg/L PBTK NA 95% Human Human -DTXSID3046409 Clint NA 49.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046409 Fup NA 0.1411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046409 Vd NA 0.8789 L/kg 1compartment NA NA Rat Human +DTXSID3046409 TK.Half.Life NA 3.25 hours 1compartment NA NA Human Human +DTXSID3046409 Css NA 0.1224 mg/L 3compartmentss NA 50% Human Human +DTXSID3046409 Css NA 0.9362 mg/L 3compartmentss NA 95% Human Human +DTXSID3046409 Css NA 0.1108 mg/L PBTK NA 50% Human Human +DTXSID3046409 Css NA 0.6901 mg/L PBTK NA 95% Human Human +DTXSID3046409 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046409 Fup 0.492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046409 Vd NA 1.741 L/kg 1compartment NA NA Rat Human DTXSID3046409 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046409 TK.Half.Life NA 0.62 hours 1compartment NA NA Rat Human -DTXSID3046409 Css NA 0.04626 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046409 Css NA 0.3179 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046409 Css NA 0.0298 mg/L PBTK NA 50% Rat Human -DTXSID3046409 Css NA 0.1914 mg/L PBTK NA 95% Rat Human -DTXSID3046451 Clint NA 56.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046451 Fup NA 0.2395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046451 Vd NA 0.2819 L/kg 1compartment NA NA Human Human +DTXSID3046409 TK.Half.Life NA 1.602 hours 1compartment NA NA Rat Human +DTXSID3046409 Css NA 0.01375 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046409 Css NA 0.08561 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046409 Css NA 0.01269 mg/L PBTK NA 50% Rat Human +DTXSID3046409 Css NA 0.06018 mg/L PBTK NA 95% Rat Human +DTXSID3046451 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046451 Fup 0.667 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046451 Vd NA 0.4717 L/kg 1compartment NA NA Human Human DTXSID3046451 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046451 TK.Half.Life NA 0.3185 hours 1compartment NA NA Human Human -DTXSID3046451 Css NA 0.03793 mg/L 3compartmentss NA 50% Human Human -DTXSID3046451 Css NA 0.282 mg/L 3compartmentss NA 95% Human Human -DTXSID3046451 Css NA 0.02433 mg/L PBTK NA 50% Human Human -DTXSID3046451 Css NA 0.1733 mg/L PBTK NA 95% Human Human -DTXSID3046451 Clint NA 56.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046451 Fup NA 0.2395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046451 Vd NA 0.2874 L/kg 1compartment NA NA Rat Human +DTXSID3046451 TK.Half.Life NA 4.575 hours 1compartment NA NA Human Human +DTXSID3046451 Css NA 0.6646 mg/L 3compartmentss NA 50% Human Human +DTXSID3046451 Css NA 4.324 mg/L 3compartmentss NA 95% Human Human +DTXSID3046451 Css NA 0.4942 mg/L PBTK NA 50% Human Human +DTXSID3046451 Css NA 2.681 mg/L PBTK NA 95% Human Human +DTXSID3046451 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046451 Fup 0.667 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046451 Vd NA 0.483 L/kg 1compartment NA NA Rat Human DTXSID3046451 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046451 TK.Half.Life NA 0.16 hours 1compartment NA NA Rat Human -DTXSID3046451 Css NA 0.02128 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046451 Css NA 0.1202 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046451 Css NA 0.01282 mg/L PBTK NA 50% Rat Human -DTXSID3046451 Css NA 0.07121 mg/L PBTK NA 95% Rat Human -DTXSID3046453 Clint NA 19.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046453 Fup NA 0.0093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046453 Vd NA 2.12 L/kg 1compartment NA NA Human Human -DTXSID3046453 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3046453 TK.Half.Life NA 38.72 hours 1compartment NA NA Human Human -DTXSID3046453 Css NA 2.87 mg/L 3compartmentss NA 50% Human Human -DTXSID3046453 Css NA 22.27 mg/L 3compartmentss NA 95% Human Human -DTXSID3046453 Css NA 1.831 mg/L PBTK NA 50% Human Human -DTXSID3046453 Css NA 13.68 mg/L PBTK NA 95% Human Human -DTXSID3046453 Clint NA 19.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046453 Fup NA 0.0093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046453 Vd NA 1.572 L/kg 1compartment NA NA Rat Human -DTXSID3046453 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3046453 TK.Half.Life NA 11.69 hours 1compartment NA NA Rat Human -DTXSID3046453 Css NA 1.59 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046453 Css NA 10.96 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046453 Css NA 0.96 mg/L PBTK NA 50% Rat Human -DTXSID3046453 Css NA 6.332 mg/L PBTK NA 95% Rat Human -DTXSID3046455 Clint NA 180 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046455 Fup 0.41 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3046455 Vd NA 3.017 L/kg 1compartment NA NA Human Human -DTXSID3046455 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046455 TK.Half.Life NA 3.37 hours 1compartment NA NA Human Human -DTXSID3046455 Css NA 0.04212 mg/L 3compartmentss NA 50% Human Human -DTXSID3046455 Css NA 0.2771 mg/L 3compartmentss NA 95% Human Human -DTXSID3046455 Css NA 0.03088 mg/L PBTK NA 50% Human Human -DTXSID3046455 Css NA 0.1918 mg/L PBTK NA 95% Human Human -DTXSID3046455 Clint NA 180 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046455 Fup 0.41 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3046455 Vd NA 2.29 L/kg 1compartment NA NA Rat Human -DTXSID3046455 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046455 TK.Half.Life NA 0.931 hours 1compartment NA NA Rat Human -DTXSID3046455 Css NA 0.02352 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046455 Css NA 0.1232 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046455 Css NA 0.01654 mg/L PBTK NA 50% Rat Human -DTXSID3046455 Css NA 0.08587 mg/L PBTK NA 95% Rat Human -DTXSID3046457 Clint NA 8.607 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3046451 TK.Half.Life NA 1.596 hours 1compartment NA NA Rat Human +DTXSID3046451 Css NA 0.00347 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046451 Css NA 0.02393 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046451 Css NA 0.002504 mg/L PBTK NA 50% Rat Human +DTXSID3046451 Css NA 0.01414 mg/L PBTK NA 95% Rat Human +DTXSID3046453 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046453 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046453 Vd NA 1.044 L/kg 1compartment NA NA Human Human +DTXSID3046453 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3046453 TK.Half.Life NA 12.06 hours 1compartment NA NA Human Human +DTXSID3046453 Css NA 1.904 mg/L 3compartmentss NA 50% Human Human +DTXSID3046453 Css NA 18.72 mg/L 3compartmentss NA 95% Human Human +DTXSID3046453 Css NA 1.151 mg/L PBTK NA 50% Human Human +DTXSID3046453 Css NA 11.06 mg/L PBTK NA 95% Human Human +DTXSID3046453 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046453 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046453 Vd NA 0.7709 L/kg 1compartment NA NA Rat Human +DTXSID3046453 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3046453 TK.Half.Life NA 5.223 hours 1compartment NA NA Rat Human +DTXSID3046453 Css NA 0.253 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046453 Css NA 1.943 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046453 Css NA 0.1486 mg/L PBTK NA 50% Rat Human +DTXSID3046453 Css NA 1.102 mg/L PBTK NA 95% Rat Human +DTXSID3046457 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3046457 Fup 0.081 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3046457 Vd NA 1.228 L/kg 1compartment NA NA Human Human +DTXSID3046457 Vd NA 1.403 L/kg 1compartment NA NA Human Human DTXSID3046457 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046457 TK.Half.Life NA 7.867 hours 1compartment NA NA Human Human -DTXSID3046457 Css NA 0.9202 mg/L 3compartmentss NA 50% Human Human -DTXSID3046457 Css NA 6.224 mg/L 3compartmentss NA 95% Human Human -DTXSID3046457 Css NA 0.597 mg/L PBTK NA 50% Human Human -DTXSID3046457 Css NA 3.881 mg/L PBTK NA 95% Human Human -DTXSID3046457 Clint NA 8.607 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3046457 TK.Half.Life NA 4.545 hours 1compartment NA NA Human Human +DTXSID3046457 Css NA 0.3776 mg/L 3compartmentss NA 50% Human Human +DTXSID3046457 Css NA 2.864 mg/L 3compartmentss NA 95% Human Human +DTXSID3046457 Css NA 0.2461 mg/L PBTK NA 50% Human Human +DTXSID3046457 Css NA 1.783 mg/L PBTK NA 95% Human Human +DTXSID3046457 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3046457 Fup 0.081 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3046457 Vd NA 0.9428 L/kg 1compartment NA NA Rat Human +DTXSID3046457 Vd NA 1.07 L/kg 1compartment NA NA Rat Human DTXSID3046457 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046457 TK.Half.Life NA 3.282 hours 1compartment NA NA Rat Human -DTXSID3046457 Css NA 0.4954 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046457 Css NA 2.549 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046457 Css NA 0.3015 mg/L PBTK NA 50% Rat Human -DTXSID3046457 Css NA 1.469 mg/L PBTK NA 95% Rat Human -DTXSID3046459 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046459 Fup NA 0.4791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046459 Vd NA 2.581 L/kg 1compartment NA NA Human Human -DTXSID3046459 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID3046459 TK.Half.Life NA 96.92 hours 1compartment NA NA Human Human -DTXSID3046459 Css NA 3.951 mg/L 3compartmentss NA 50% Human Human -DTXSID3046459 Css NA 13.24 mg/L 3compartmentss NA 95% Human Human -DTXSID3046459 Css NA 3.144 mg/L PBTK NA 50% Human Human -DTXSID3046459 Css NA 9.11 mg/L PBTK NA 95% Human Human -DTXSID3046459 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046459 Fup NA 0.4791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046459 Vd NA 2.012 L/kg 1compartment NA NA Rat Human -DTXSID3046459 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3046459 TK.Half.Life NA 13.2 hours 1compartment NA NA Rat Human -DTXSID3046459 Css NA 1.054 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046459 Css NA 3.007 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046459 Css NA 0.8136 mg/L PBTK NA 50% Rat Human -DTXSID3046459 Css NA 1.919 mg/L PBTK NA 95% Rat Human -DTXSID3046530 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046530 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046530 Vd NA 0.7322 L/kg 1compartment NA NA Human Human +DTXSID3046457 TK.Half.Life NA 1.803 hours 1compartment NA NA Rat Human +DTXSID3046457 Css NA 0.04888 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046457 Css NA 0.2858 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046457 Css NA 0.03118 mg/L PBTK NA 50% Rat Human +DTXSID3046457 Css NA 0.1735 mg/L PBTK NA 95% Rat Human +DTXSID3046459 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046459 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046459 Vd NA 1.753 L/kg 1compartment NA NA Human Human +DTXSID3046459 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3046459 TK.Half.Life NA 4.8 hours 1compartment NA NA Human Human +DTXSID3046459 Css NA 0.2345 mg/L 3compartmentss NA 50% Human Human +DTXSID3046459 Css NA 1.411 mg/L 3compartmentss NA 95% Human Human +DTXSID3046459 Css NA 0.1824 mg/L PBTK NA 50% Human Human +DTXSID3046459 Css NA 0.9813 mg/L PBTK NA 95% Human Human +DTXSID3046459 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046459 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046459 Vd NA 1.407 L/kg 1compartment NA NA Rat Human +DTXSID3046459 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3046459 TK.Half.Life NA 1.812 hours 1compartment NA NA Rat Human +DTXSID3046459 Css NA 0.02728 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046459 Css NA 0.1204 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046459 Css NA 0.0213 mg/L PBTK NA 50% Rat Human +DTXSID3046459 Css NA 0.0828 mg/L PBTK NA 95% Rat Human +DTXSID3046530 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046530 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046530 Vd NA 0.6425 L/kg 1compartment NA NA Human Human DTXSID3046530 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046530 TK.Half.Life NA 4.738 hours 1compartment NA NA Human Human -DTXSID3046530 Css NA 0.8392 mg/L 3compartmentss NA 50% Human Human -DTXSID3046530 Css NA 5.532 mg/L 3compartmentss NA 95% Human Human -DTXSID3046530 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID3046530 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID3046530 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046530 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046530 Vd NA 0.7766 L/kg 1compartment NA NA Rat Human +DTXSID3046530 TK.Half.Life NA 5.177 hours 1compartment NA NA Human Human +DTXSID3046530 Css NA 0.8666 mg/L 3compartmentss NA 50% Human Human +DTXSID3046530 Css NA 4.968 mg/L 3compartmentss NA 95% Human Human +DTXSID3046530 Css NA 0.6936 mg/L PBTK NA 50% Human Human +DTXSID3046530 Css NA 3.236 mg/L PBTK NA 95% Human Human +DTXSID3046530 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046530 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046530 Vd NA 0.6809 L/kg 1compartment NA NA Rat Human DTXSID3046530 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046530 TK.Half.Life NA 1.712 hours 1compartment NA NA Rat Human -DTXSID3046530 Css NA 0.2108 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046530 Css NA 1.312 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046530 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID3046530 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID3046532 Clint NA 2.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046532 Fup NA 0.1025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046532 Vd NA 2.312 L/kg 1compartment NA NA Human Human -DTXSID3046532 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID3046532 TK.Half.Life NA 62.22 hours 1compartment NA NA Human Human -DTXSID3046532 Css NA 3.685 mg/L 3compartmentss NA 50% Human Human -DTXSID3046532 Css NA 17.36 mg/L 3compartmentss NA 95% Human Human -DTXSID3046532 Css NA 2.52 mg/L PBTK NA 50% Human Human -DTXSID3046532 Css NA 11.19 mg/L PBTK NA 95% Human Human -DTXSID3046532 Clint NA 2.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046532 Fup NA 0.1025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046532 Vd NA 1.746 L/kg 1compartment NA NA Rat Human -DTXSID3046532 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID3046532 TK.Half.Life NA 15.3 hours 1compartment NA NA Rat Human -DTXSID3046532 Css NA 1.751 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046532 Css NA 5.988 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046532 Css NA 1.144 mg/L PBTK NA 50% Rat Human -DTXSID3046532 Css NA 3.581 mg/L PBTK NA 95% Rat Human -DTXSID3046534 Clint NA 0.1102 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046534 Fup NA 0.845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046534 Vd NA 0.6579 L/kg 1compartment NA NA Human Human +DTXSID3046530 TK.Half.Life NA 1.87 hours 1compartment NA NA Rat Human +DTXSID3046530 Css NA 0.01614 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046530 Css NA 0.1218 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046530 Css NA 0.01229 mg/L PBTK NA 50% Rat Human +DTXSID3046530 Css NA 0.07723 mg/L PBTK NA 95% Rat Human +DTXSID3046532 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046532 Fup 0.0627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046532 Vd NA 1.994 L/kg 1compartment NA NA Human Human +DTXSID3046532 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3046532 TK.Half.Life NA 9.201 hours 1compartment NA NA Human Human +DTXSID3046532 Css NA 0.5719 mg/L 3compartmentss NA 50% Human Human +DTXSID3046532 Css NA 3.816 mg/L 3compartmentss NA 95% Human Human +DTXSID3046532 Css NA 0.3778 mg/L PBTK NA 50% Human Human +DTXSID3046532 Css NA 2.414 mg/L PBTK NA 95% Human Human +DTXSID3046532 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046532 Fup 0.0627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046532 Vd NA 1.499 L/kg 1compartment NA NA Rat Human +DTXSID3046532 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3046532 TK.Half.Life NA 3.022 hours 1compartment NA NA Rat Human +DTXSID3046532 Css NA 0.07332 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046532 Css NA 0.4064 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046532 Css NA 0.04764 mg/L PBTK NA 50% Rat Human +DTXSID3046532 Css NA 0.2545 mg/L PBTK NA 95% Rat Human +DTXSID3046534 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046534 Fup 0.913 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046534 Vd NA 0.6792 L/kg 1compartment NA NA Human Human DTXSID3046534 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046534 TK.Half.Life NA 3.898 hours 1compartment NA NA Human Human -DTXSID3046534 Css NA 0.7416 mg/L 3compartmentss NA 50% Human Human -DTXSID3046534 Css NA 4.202 mg/L 3compartmentss NA 95% Human Human -DTXSID3046534 Css NA 0.5993 mg/L PBTK NA 50% Human Human -DTXSID3046534 Css NA 2.681 mg/L PBTK NA 95% Human Human -DTXSID3046534 Clint NA 0.1102 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046534 Fup NA 0.845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046534 Vd NA 0.6987 L/kg 1compartment NA NA Rat Human +DTXSID3046534 TK.Half.Life NA 4.814 hours 1compartment NA NA Human Human +DTXSID3046534 Css NA 0.7958 mg/L 3compartmentss NA 50% Human Human +DTXSID3046534 Css NA 4.291 mg/L 3compartmentss NA 95% Human Human +DTXSID3046534 Css NA 0.6494 mg/L PBTK NA 50% Human Human +DTXSID3046534 Css NA 2.801 mg/L PBTK NA 95% Human Human +DTXSID3046534 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046534 Fup 0.913 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046534 Vd NA 0.7237 L/kg 1compartment NA NA Rat Human DTXSID3046534 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046534 TK.Half.Life NA 1.595 hours 1compartment NA NA Rat Human -DTXSID3046534 Css NA 0.2161 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046534 Css NA 1.271 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046534 Css NA 0.1698 mg/L PBTK NA 50% Rat Human -DTXSID3046534 Css NA 0.7535 mg/L PBTK NA 95% Rat Human -DTXSID3046536 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046536 Fup NA 0.8088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046536 Vd NA 0.5198 L/kg 1compartment NA NA Human Human +DTXSID3046534 TK.Half.Life NA 1.748 hours 1compartment NA NA Rat Human +DTXSID3046534 Css NA 0.01485 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046534 Css NA 0.1071 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046534 Css NA 0.01162 mg/L PBTK NA 50% Rat Human +DTXSID3046534 Css NA 0.0697 mg/L PBTK NA 95% Rat Human +DTXSID3046536 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046536 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046536 Vd NA 0.5051 L/kg 1compartment NA NA Human Human DTXSID3046536 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046536 TK.Half.Life NA 4.158 hours 1compartment NA NA Human Human -DTXSID3046536 Css NA 1.086 mg/L 3compartmentss NA 50% Human Human -DTXSID3046536 Css NA 5.81 mg/L 3compartmentss NA 95% Human Human -DTXSID3046536 Css NA 0.8188 mg/L PBTK NA 50% Human Human -DTXSID3046536 Css NA 3.653 mg/L PBTK NA 95% Human Human -DTXSID3046536 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046536 Fup NA 0.8088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046536 Vd NA 0.5412 L/kg 1compartment NA NA Rat Human +DTXSID3046536 TK.Half.Life NA 4.844 hours 1compartment NA NA Human Human +DTXSID3046536 Css NA 1.179 mg/L 3compartmentss NA 50% Human Human +DTXSID3046536 Css NA 7.163 mg/L 3compartmentss NA 95% Human Human +DTXSID3046536 Css NA 0.881 mg/L PBTK NA 50% Human Human +DTXSID3046536 Css NA 4.408 mg/L PBTK NA 95% Human Human +DTXSID3046536 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046536 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046536 Vd NA 0.5191 L/kg 1compartment NA NA Rat Human DTXSID3046536 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046536 TK.Half.Life NA 1.476 hours 1compartment NA NA Rat Human -DTXSID3046536 Css NA 0.2771 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046536 Css NA 1.565 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046536 Css NA 0.2007 mg/L PBTK NA 50% Rat Human -DTXSID3046536 Css NA 0.909 mg/L PBTK NA 95% Rat Human -DTXSID3046580 Clint NA 85.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046580 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046580 Vd NA 1.882 L/kg 1compartment NA NA Human Human +DTXSID3046536 TK.Half.Life NA 1.696 hours 1compartment NA NA Rat Human +DTXSID3046536 Css NA 0.07132 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046536 Css NA 0.4234 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046536 Css NA 0.0527 mg/L PBTK NA 50% Rat Human +DTXSID3046536 Css NA 0.2527 mg/L PBTK NA 95% Rat Human +DTXSID3046580 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046580 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046580 Vd NA 2.687 L/kg 1compartment NA NA Human Human DTXSID3046580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046580 TK.Half.Life NA 4.401 hours 1compartment NA NA Human Human -DTXSID3046580 Css NA 0.2499 mg/L 3compartmentss NA 50% Human Human -DTXSID3046580 Css NA 1.787 mg/L 3compartmentss NA 95% Human Human -DTXSID3046580 Css NA 0.1614 mg/L PBTK NA 50% Human Human -DTXSID3046580 Css NA 1.109 mg/L PBTK NA 95% Human Human -DTXSID3046580 Clint NA 85.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046580 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046580 Vd NA 1.406 L/kg 1compartment NA NA Rat Human +DTXSID3046580 TK.Half.Life NA 13.62 hours 1compartment NA NA Human Human +DTXSID3046580 Css NA 0.559 mg/L 3compartmentss NA 50% Human Human +DTXSID3046580 Css NA 3.572 mg/L 3compartmentss NA 95% Human Human +DTXSID3046580 Css NA 0.3873 mg/L PBTK NA 50% Human Human +DTXSID3046580 Css NA 2.431 mg/L PBTK NA 95% Human Human +DTXSID3046580 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046580 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046580 Vd NA 2.023 L/kg 1compartment NA NA Rat Human DTXSID3046580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046580 TK.Half.Life NA 1.493 hours 1compartment NA NA Rat Human -DTXSID3046580 Css NA 0.141 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046580 Css NA 0.8551 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046580 Css NA 0.08556 mg/L PBTK NA 50% Rat Human -DTXSID3046580 Css NA 0.4939 mg/L PBTK NA 95% Rat Human -DTXSID3046584 Clint NA 0.2893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046584 Fup NA 0.4516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046584 Vd NA 0.4469 L/kg 1compartment NA NA Human Human +DTXSID3046580 TK.Half.Life NA 3.164 hours 1compartment NA NA Rat Human +DTXSID3046580 Css NA 0.07242 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046580 Css NA 0.3688 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046580 Css NA 0.04955 mg/L PBTK NA 50% Rat Human +DTXSID3046580 Css NA 0.2441 mg/L PBTK NA 95% Rat Human +DTXSID3046584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046584 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046584 Vd NA 0.3514 L/kg 1compartment NA NA Human Human DTXSID3046584 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046584 TK.Half.Life NA 4.359 hours 1compartment NA NA Human Human -DTXSID3046584 Css NA 1.089 mg/L 3compartmentss NA 50% Human Human -DTXSID3046584 Css NA 5.303 mg/L 3compartmentss NA 95% Human Human -DTXSID3046584 Css NA 0.7932 mg/L PBTK NA 50% Human Human -DTXSID3046584 Css NA 3.295 mg/L PBTK NA 95% Human Human -DTXSID3046584 Clint NA 0.2893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046584 Fup NA 0.4516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046584 Vd NA 0.4512 L/kg 1compartment NA NA Rat Human +DTXSID3046584 TK.Half.Life NA 0.483 hours 1compartment NA NA Human Human +DTXSID3046584 Css NA 0.07366 mg/L 3compartmentss NA 50% Human Human +DTXSID3046584 Css NA 0.5396 mg/L 3compartmentss NA 95% Human Human +DTXSID3046584 Css NA 0.04905 mg/L PBTK NA 50% Human Human +DTXSID3046584 Css NA 0.3457 mg/L PBTK NA 95% Human Human +DTXSID3046584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046584 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046584 Vd NA 0.3545 L/kg 1compartment NA NA Rat Human DTXSID3046584 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046584 TK.Half.Life NA 1.791 hours 1compartment NA NA Rat Human -DTXSID3046584 Css NA 0.3643 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046584 Css NA 1.499 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046584 Css NA 0.2516 mg/L PBTK NA 50% Rat Human -DTXSID3046584 Css NA 0.878 mg/L PBTK NA 95% Rat Human +DTXSID3046584 TK.Half.Life NA 0.258 hours 1compartment NA NA Rat Human +DTXSID3046584 Css NA 0.009344 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046584 Css NA 0.05334 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046584 Css NA 0.006157 mg/L PBTK NA 50% Rat Human +DTXSID3046584 Css NA 0.03331 mg/L PBTK NA 95% Rat Human DTXSID3046586 Clint NA 1.021 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3046586 Fup NA 0.8157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046586 Vd NA 0.8562 L/kg 1compartment NA NA Human Human +DTXSID3046586 Vd NA 1.179 L/kg 1compartment NA NA Human Human DTXSID3046586 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046586 TK.Half.Life NA 2.743 hours 1compartment NA NA Human Human -DTXSID3046586 Css NA 0.365 mg/L 3compartmentss NA 50% Human Human -DTXSID3046586 Css NA 2.421 mg/L 3compartmentss NA 95% Human Human -DTXSID3046586 Css NA 0.3064 mg/L PBTK NA 50% Human Human -DTXSID3046586 Css NA 1.585 mg/L PBTK NA 95% Human Human +DTXSID3046586 TK.Half.Life NA 3.894 hours 1compartment NA NA Human Human +DTXSID3046586 Css NA 0.2948 mg/L 3compartmentss NA 50% Human Human +DTXSID3046586 Css NA 2.068 mg/L 3compartmentss NA 95% Human Human +DTXSID3046586 Css NA 0.26 mg/L PBTK NA 50% Human Human +DTXSID3046586 Css NA 1.367 mg/L PBTK NA 95% Human Human DTXSID3046586 Clint NA 1.021 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3046586 Fup NA 0.8157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046586 Vd NA 0.8598 L/kg 1compartment NA NA Rat Human +DTXSID3046586 Vd NA 1.108 L/kg 1compartment NA NA Rat Human DTXSID3046586 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046586 TK.Half.Life NA 1.324 hours 1compartment NA NA Rat Human -DTXSID3046586 Css NA 0.1366 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046586 Css NA 0.873 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046586 Css NA 0.1126 mg/L PBTK NA 50% Rat Human -DTXSID3046586 Css NA 0.5289 mg/L PBTK NA 95% Rat Human -DTXSID3046588 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046588 Fup NA 0.1319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046588 Vd NA 0.4546 L/kg 1compartment NA NA Human Human -DTXSID3046588 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3046588 TK.Half.Life NA 22.3 hours 1compartment NA NA Human Human -DTXSID3046588 Css NA 6.892 mg/L 3compartmentss NA 50% Human Human -DTXSID3046588 Css NA 32.68 mg/L 3compartmentss NA 95% Human Human -DTXSID3046588 Css NA 4.596 mg/L PBTK NA 50% Human Human -DTXSID3046588 Css NA 19.62 mg/L PBTK NA 95% Human Human -DTXSID3046588 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046588 Fup NA 0.1319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046588 Vd NA 0.4486 L/kg 1compartment NA NA Rat Human -DTXSID3046588 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046588 TK.Half.Life NA 7.498 hours 1compartment NA NA Rat Human -DTXSID3046588 Css NA 1.919 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046588 Css NA 7.807 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046588 Css NA 1.206 mg/L PBTK NA 50% Rat Human -DTXSID3046588 Css NA 4.405 mg/L PBTK NA 95% Rat Human -DTXSID3046615 Clint NA 10.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046615 Fup NA 0.9824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046615 Vd NA 3.687 L/kg 1compartment NA NA Human Human -DTXSID3046615 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3046615 TK.Half.Life NA 15.32 hours 1compartment NA NA Human Human -DTXSID3046615 Css NA 0.3778 mg/L 3compartmentss NA 50% Human Human -DTXSID3046615 Css NA 2.425 mg/L 3compartmentss NA 95% Human Human -DTXSID3046615 Css NA 0.3166 mg/L PBTK NA 50% Human Human -DTXSID3046615 Css NA 1.882 mg/L PBTK NA 95% Human Human -DTXSID3046615 Clint NA 10.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046615 Fup NA 0.9824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046615 Vd NA 3.005 L/kg 1compartment NA NA Rat Human +DTXSID3046586 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human +DTXSID3046586 Css NA 0.008035 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046586 Css NA 0.06827 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046586 Css NA 0.006933 mg/L PBTK NA 50% Rat Human +DTXSID3046586 Css NA 0.04636 mg/L PBTK NA 95% Rat Human +DTXSID3046615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046615 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046615 Vd NA 0.702 L/kg 1compartment NA NA Human Human +DTXSID3046615 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3046615 TK.Half.Life NA 1.338 hours 1compartment NA NA Human Human +DTXSID3046615 Css NA 0.157 mg/L 3compartmentss NA 50% Human Human +DTXSID3046615 Css NA 1.302 mg/L 3compartmentss NA 95% Human Human +DTXSID3046615 Css NA 0.105 mg/L PBTK NA 50% Human Human +DTXSID3046615 Css NA 0.8232 mg/L PBTK NA 95% Human Human +DTXSID3046615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046615 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046615 Vd NA 0.6946 L/kg 1compartment NA NA Rat Human DTXSID3046615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046615 TK.Half.Life NA 2.809 hours 1compartment NA NA Rat Human -DTXSID3046615 Css NA 0.1962 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046615 Css NA 0.9599 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046615 Css NA 0.1618 mg/L PBTK NA 50% Rat Human -DTXSID3046615 Css NA 0.7409 mg/L PBTK NA 95% Rat Human -DTXSID3046617 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046617 Fup NA 0.0764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046617 Vd NA 0.6155 L/kg 1compartment NA NA Human Human -DTXSID3046617 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID3046617 TK.Half.Life NA 54.66 hours 1compartment NA NA Human Human -DTXSID3046617 Css NA 13.7 mg/L 3compartmentss NA 50% Human Human -DTXSID3046617 Css NA 62.77 mg/L 3compartmentss NA 95% Human Human -DTXSID3046617 Css NA 8.683 mg/L PBTK NA 50% Human Human -DTXSID3046617 Css NA 37.04 mg/L PBTK NA 95% Human Human -DTXSID3046617 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046617 Fup NA 0.0764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046617 Vd NA 0.5027 L/kg 1compartment NA NA Rat Human -DTXSID3046617 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3046617 TK.Half.Life NA 14.68 hours 1compartment NA NA Rat Human -DTXSID3046617 Css NA 3.855 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046617 Css NA 14.65 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046617 Css NA 2.286 mg/L PBTK NA 50% Rat Human -DTXSID3046617 Css NA 8.132 mg/L PBTK NA 95% Rat Human -DTXSID3046619 Clint NA 12.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046619 Fup NA 0.0219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046619 Vd NA 2.129 L/kg 1compartment NA NA Human Human +DTXSID3046615 TK.Half.Life NA 0.7569 hours 1compartment NA NA Rat Human +DTXSID3046615 Css NA 0.0203 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046615 Css NA 0.1262 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046615 Css NA 0.01332 mg/L PBTK NA 50% Rat Human +DTXSID3046615 Css NA 0.07731 mg/L PBTK NA 95% Rat Human +DTXSID3046617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046617 Fup 0.0925 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046617 Vd NA 0.7734 L/kg 1compartment NA NA Human Human +DTXSID3046617 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3046617 TK.Half.Life NA 2.097 hours 1compartment NA NA Human Human +DTXSID3046617 Css NA 0.2619 mg/L 3compartmentss NA 50% Human Human +DTXSID3046617 Css NA 2.244 mg/L 3compartmentss NA 95% Human Human +DTXSID3046617 Css NA 0.1693 mg/L PBTK NA 50% Human Human +DTXSID3046617 Css NA 1.387 mg/L PBTK NA 95% Human Human +DTXSID3046617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046617 Fup 0.0925 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046617 Vd NA 0.6221 L/kg 1compartment NA NA Rat Human +DTXSID3046617 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3046617 TK.Half.Life NA 0.9708 hours 1compartment NA NA Rat Human +DTXSID3046617 Css NA 0.01249 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046617 Css NA 0.1156 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046617 Css NA 0.007894 mg/L PBTK NA 50% Rat Human +DTXSID3046617 Css NA 0.06871 mg/L PBTK NA 95% Rat Human +DTXSID3046619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046619 Fup 0.0126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046619 Vd NA 2.486 L/kg 1compartment NA NA Human Human DTXSID3046619 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3046619 TK.Half.Life NA 34.8 hours 1compartment NA NA Human Human -DTXSID3046619 Css NA 2.554 mg/L 3compartmentss NA 50% Human Human -DTXSID3046619 Css NA 19.11 mg/L 3compartmentss NA 95% Human Human -DTXSID3046619 Css NA 1.646 mg/L PBTK NA 50% Human Human -DTXSID3046619 Css NA 11.97 mg/L PBTK NA 95% Human Human -DTXSID3046619 Clint NA 12.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046619 Fup NA 0.0219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046619 Vd NA 1.585 L/kg 1compartment NA NA Rat Human +DTXSID3046619 TK.Half.Life NA 39.14 hours 1compartment NA NA Human Human +DTXSID3046619 Css NA 2.244 mg/L 3compartmentss NA 50% Human Human +DTXSID3046619 Css NA 16.18 mg/L 3compartmentss NA 95% Human Human +DTXSID3046619 Css NA 1.475 mg/L PBTK NA 50% Human Human +DTXSID3046619 Css NA 10.24 mg/L PBTK NA 95% Human Human +DTXSID3046619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046619 Fup 0.0126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046619 Vd NA 1.853 L/kg 1compartment NA NA Rat Human DTXSID3046619 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3046619 TK.Half.Life NA 10.46 hours 1compartment NA NA Rat Human -DTXSID3046619 Css NA 1.374 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046619 Css NA 8.364 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046619 Css NA 0.8433 mg/L PBTK NA 50% Rat Human -DTXSID3046619 Css NA 4.913 mg/L PBTK NA 95% Rat Human -DTXSID3046663 Clint NA 12.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046663 Fup NA 0.0056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046663 Vd NA 196.7 L/kg 1compartment NA NA Human Human -DTXSID3046663 Days.Css NA 51 Days PBTK NA NA Human Human -DTXSID3046663 TK.Half.Life NA 270.2 hours 1compartment NA NA Human Human -DTXSID3046663 Css NA 0.007234 mg/L 3compartmentss NA 50% Human Human -DTXSID3046663 Css NA 0.28 mg/L 3compartmentss NA 95% Human Human -DTXSID3046663 Css NA 0.1548 mg/L PBTK NA 50% Human Human -DTXSID3046663 Css NA 1.636 mg/L PBTK NA 95% Human Human -DTXSID3046663 Clint NA 12.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046663 Fup NA 0.0056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046663 Vd NA 176.8 L/kg 1compartment NA NA Rat Human -DTXSID3046663 Days.Css NA 38 Days PBTK NA NA Rat Human -DTXSID3046663 TK.Half.Life NA 161.6 hours 1compartment NA NA Rat Human -DTXSID3046663 Css NA 0.003763 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046663 Css NA 0.1212 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046663 Css NA 0.08356 mg/L PBTK NA 50% Rat Human -DTXSID3046663 Css NA 0.7155 mg/L PBTK NA 95% Rat Human -DTXSID3046665 Clint NA 155.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046665 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046665 Vd NA 3.071 L/kg 1compartment NA NA Human Human -DTXSID3046665 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046665 TK.Half.Life NA 12.53 hours 1compartment NA NA Human Human -DTXSID3046665 Css NA 0.4171 mg/L 3compartmentss NA 50% Human Human -DTXSID3046665 Css NA 2.703 mg/L 3compartmentss NA 95% Human Human -DTXSID3046665 Css NA 0.2892 mg/L PBTK NA 50% Human Human -DTXSID3046665 Css NA 1.807 mg/L PBTK NA 95% Human Human -DTXSID3046665 Clint NA 155.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046665 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046665 Vd NA 2.302 L/kg 1compartment NA NA Rat Human -DTXSID3046665 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046665 TK.Half.Life NA 2.224 hours 1compartment NA NA Rat Human -DTXSID3046665 Css NA 0.2342 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046665 Css NA 1.255 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046665 Css NA 0.1548 mg/L PBTK NA 50% Rat Human -DTXSID3046665 Css NA 0.7873 mg/L PBTK NA 95% Rat Human -DTXSID3046740 Clint NA 33.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046740 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046740 Vd NA 0.7476 L/kg 1compartment NA NA Human Human -DTXSID3046740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046740 TK.Half.Life NA 10.09 hours 1compartment NA NA Human Human -DTXSID3046740 Css NA 2.4 mg/L 3compartmentss NA 50% Human Human -DTXSID3046740 Css NA 22.13 mg/L 3compartmentss NA 95% Human Human -DTXSID3046740 Css NA 1.435 mg/L PBTK NA 50% Human Human -DTXSID3046740 Css NA 13.02 mg/L PBTK NA 95% Human Human -DTXSID3046740 Clint NA 33.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046740 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046740 Vd NA 0.553 L/kg 1compartment NA NA Rat Human -DTXSID3046740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046740 TK.Half.Life NA 4.693 hours 1compartment NA NA Rat Human -DTXSID3046740 Css NA 1.363 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046740 Css NA 11.17 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046740 Css NA 0.7578 mg/L PBTK NA 50% Rat Human -DTXSID3046740 Css NA 6.103 mg/L PBTK NA 95% Rat Human -DTXSID3046742 Clint NA 32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046742 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3046742 Vd NA 0.972 L/kg 1compartment NA NA Human Human -DTXSID3046742 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046742 TK.Half.Life NA 0.6129 hours 1compartment NA NA Human Human -DTXSID3046742 Css NA 0.01562 mg/L 3compartmentss NA 50% Human Human -DTXSID3046742 Css NA 0.2069 mg/L 3compartmentss NA 95% Human Human -DTXSID3046742 Css NA 0.01358 mg/L PBTK NA 50% Human Human -DTXSID3046742 Css NA 0.1599 mg/L PBTK NA 95% Human Human -DTXSID3046742 Clint NA 32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046742 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3046742 Vd NA 0.9802 L/kg 1compartment NA NA Rat Human -DTXSID3046742 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046742 TK.Half.Life NA 0.2875 hours 1compartment NA NA Rat Human -DTXSID3046742 Css NA 0.007831 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046742 Css NA 0.08533 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046742 Css NA 0.006785 mg/L PBTK NA 50% Rat Human -DTXSID3046742 Css NA 0.06321 mg/L PBTK NA 95% Rat Human -DTXSID3046744 Clint NA 5.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046744 Fup NA 0.0854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046744 Vd NA 1.236 L/kg 1compartment NA NA Human Human +DTXSID3046619 TK.Half.Life NA 9.693 hours 1compartment NA NA Rat Human +DTXSID3046619 Css NA 0.2906 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046619 Css NA 1.836 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046619 Css NA 0.1883 mg/L PBTK NA 50% Rat Human +DTXSID3046619 Css NA 1.148 mg/L PBTK NA 95% Rat Human +DTXSID3046663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046663 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046663 Vd NA 50.21 L/kg 1compartment NA NA Human Human +DTXSID3046663 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3046663 TK.Half.Life NA 18.45 hours 1compartment NA NA Human Human +DTXSID3046663 Css NA 0.005895 mg/L 3compartmentss NA 50% Human Human +DTXSID3046663 Css NA 0.1519 mg/L 3compartmentss NA 95% Human Human +DTXSID3046663 Css NA 0.02949 mg/L PBTK NA 50% Human Human +DTXSID3046663 Css NA 0.314 mg/L PBTK NA 95% Human Human +DTXSID3046663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046663 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046663 Vd NA 43.37 L/kg 1compartment NA NA Rat Human +DTXSID3046663 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3046663 TK.Half.Life NA 9.137 hours 1compartment NA NA Rat Human +DTXSID3046663 Css NA 0.0007138 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046663 Css NA 0.01651 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046663 Css NA 0.003877 mg/L PBTK NA 50% Rat Human +DTXSID3046663 Css NA 0.0336 mg/L PBTK NA 95% Rat Human +DTXSID3046665 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046665 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046665 Vd NA 7.841 L/kg 1compartment NA NA Human Human +DTXSID3046665 Days.Css NA 46 Days PBTK NA NA Human Human +DTXSID3046665 TK.Half.Life NA 234.3 hours 1compartment NA NA Human Human +DTXSID3046665 Css NA 2.31 mg/L 3compartmentss NA 50% Human Human +DTXSID3046665 Css NA 14.42 mg/L 3compartmentss NA 95% Human Human +DTXSID3046665 Css NA 2.343 mg/L PBTK NA 50% Human Human +DTXSID3046665 Css NA 13.98 mg/L PBTK NA 95% Human Human +DTXSID3046665 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046665 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046665 Vd NA 6.107 L/kg 1compartment NA NA Rat Human +DTXSID3046665 Days.Css NA 28 Days PBTK NA NA Rat Human +DTXSID3046665 TK.Half.Life NA 31.93 hours 1compartment NA NA Rat Human +DTXSID3046665 Css NA 0.2965 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046665 Css NA 1.366 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046665 Css NA 0.3077 mg/L PBTK NA 50% Rat Human +DTXSID3046665 Css NA 1.443 mg/L PBTK NA 95% Rat Human +DTXSID3046740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046740 Fup 0.0156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046740 Vd NA 2.53 L/kg 1compartment NA NA Human Human +DTXSID3046740 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3046740 TK.Half.Life NA 36.54 hours 1compartment NA NA Human Human +DTXSID3046740 Css NA 1.998 mg/L 3compartmentss NA 50% Human Human +DTXSID3046740 Css NA 15.04 mg/L 3compartmentss NA 95% Human Human +DTXSID3046740 Css NA 1.322 mg/L PBTK NA 50% Human Human +DTXSID3046740 Css NA 9.436 mg/L PBTK NA 95% Human Human +DTXSID3046740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046740 Fup 0.0156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046740 Vd NA 1.886 L/kg 1compartment NA NA Rat Human +DTXSID3046740 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3046740 TK.Half.Life NA 8.797 hours 1compartment NA NA Rat Human +DTXSID3046740 Css NA 0.2596 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046740 Css NA 1.615 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046740 Css NA 0.1687 mg/L PBTK NA 50% Rat Human +DTXSID3046740 Css NA 1.008 mg/L PBTK NA 95% Rat Human +DTXSID3046744 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046744 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046744 Vd NA 3.379 L/kg 1compartment NA NA Human Human DTXSID3046744 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046744 TK.Half.Life NA 10.1 hours 1compartment NA NA Human Human -DTXSID3046744 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human -DTXSID3046744 Css NA 8.312 mg/L 3compartmentss NA 95% Human Human -DTXSID3046744 Css NA 0.7982 mg/L PBTK NA 50% Human Human -DTXSID3046744 Css NA 5.195 mg/L PBTK NA 95% Human Human -DTXSID3046744 Clint NA 5.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046744 Fup NA 0.0854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046744 Vd NA 1.216 L/kg 1compartment NA NA Rat Human +DTXSID3046744 TK.Half.Life NA 10.36 hours 1compartment NA NA Human Human +DTXSID3046744 Css NA 0.232 mg/L 3compartmentss NA 50% Human Human +DTXSID3046744 Css NA 1.43 mg/L 3compartmentss NA 95% Human Human +DTXSID3046744 Css NA 0.2209 mg/L PBTK NA 50% Human Human +DTXSID3046744 Css NA 1.181 mg/L PBTK NA 95% Human Human +DTXSID3046744 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046744 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046744 Vd NA 3.014 L/kg 1compartment NA NA Rat Human DTXSID3046744 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046744 TK.Half.Life NA 6.059 hours 1compartment NA NA Rat Human -DTXSID3046744 Css NA 0.5919 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046744 Css NA 3.228 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046744 Css NA 0.3938 mg/L PBTK NA 50% Rat Human -DTXSID3046744 Css NA 1.88 mg/L PBTK NA 95% Rat Human -DTXSID3046748 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046748 Fup NA 0.7879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046748 Vd NA 0.5383 L/kg 1compartment NA NA Human Human +DTXSID3046744 TK.Half.Life NA 3.792 hours 1compartment NA NA Rat Human +DTXSID3046744 Css NA 0.02688 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046744 Css NA 0.1215 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046744 Css NA 0.02636 mg/L PBTK NA 50% Rat Human +DTXSID3046744 Css NA 0.09962 mg/L PBTK NA 95% Rat Human +DTXSID3046748 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046748 Fup 0.654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046748 Vd NA 0.4861 L/kg 1compartment NA NA Human Human DTXSID3046748 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046748 TK.Half.Life NA 4.421 hours 1compartment NA NA Human Human -DTXSID3046748 Css NA 1.084 mg/L 3compartmentss NA 50% Human Human -DTXSID3046748 Css NA 6.403 mg/L 3compartmentss NA 95% Human Human -DTXSID3046748 Css NA 0.8229 mg/L PBTK NA 50% Human Human -DTXSID3046748 Css NA 4.021 mg/L PBTK NA 95% Human Human -DTXSID3046748 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046748 Fup NA 0.7879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046748 Vd NA 0.5661 L/kg 1compartment NA NA Rat Human +DTXSID3046748 TK.Half.Life NA 4.81 hours 1compartment NA NA Human Human +DTXSID3046748 Css NA 0.6752 mg/L 3compartmentss NA 50% Human Human +DTXSID3046748 Css NA 4.227 mg/L 3compartmentss NA 95% Human Human +DTXSID3046748 Css NA 0.5026 mg/L PBTK NA 50% Human Human +DTXSID3046748 Css NA 2.647 mg/L PBTK NA 95% Human Human +DTXSID3046748 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046748 Fup 0.654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046748 Vd NA 0.5105 L/kg 1compartment NA NA Rat Human DTXSID3046748 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046748 TK.Half.Life NA 1.584 hours 1compartment NA NA Rat Human -DTXSID3046748 Css NA 0.2769 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046748 Css NA 1.607 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046748 Css NA 0.2028 mg/L PBTK NA 50% Rat Human -DTXSID3046748 Css NA 0.9348 mg/L PBTK NA 95% Rat Human -DTXSID3046790 Clint NA 89.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046790 Fup NA 0.1151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046790 Vd NA 2.789 L/kg 1compartment NA NA Human Human -DTXSID3046790 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046790 TK.Half.Life NA 5.514 hours 1compartment NA NA Human Human -DTXSID3046790 Css NA 0.1566 mg/L 3compartmentss NA 50% Human Human -DTXSID3046790 Css NA 1.076 mg/L 3compartmentss NA 95% Human Human -DTXSID3046790 Css NA 0.109 mg/L PBTK NA 50% Human Human -DTXSID3046790 Css NA 0.7257 mg/L PBTK NA 95% Human Human -DTXSID3046790 Clint NA 89.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046790 Fup NA 0.1151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046790 Vd NA 2.099 L/kg 1compartment NA NA Rat Human +DTXSID3046748 TK.Half.Life NA 1.721 hours 1compartment NA NA Rat Human +DTXSID3046748 Css NA 0.003549 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046748 Css NA 0.02374 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046748 Css NA 0.002548 mg/L PBTK NA 50% Rat Human +DTXSID3046748 Css NA 0.0142 mg/L PBTK NA 95% Rat Human +DTXSID3046790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046790 Fup 0.0743 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046790 Vd NA 2.617 L/kg 1compartment NA NA Human Human +DTXSID3046790 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3046790 TK.Half.Life NA 15.86 hours 1compartment NA NA Human Human +DTXSID3046790 Css NA 0.7154 mg/L 3compartmentss NA 50% Human Human +DTXSID3046790 Css NA 4.602 mg/L 3compartmentss NA 95% Human Human +DTXSID3046790 Css NA 0.4888 mg/L PBTK NA 50% Human Human +DTXSID3046790 Css NA 3.017 mg/L PBTK NA 95% Human Human +DTXSID3046790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046790 Fup 0.0743 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046790 Vd NA 1.966 L/kg 1compartment NA NA Rat Human DTXSID3046790 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046790 TK.Half.Life NA 1.38 hours 1compartment NA NA Rat Human -DTXSID3046790 Css NA 0.08804 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046790 Css NA 0.4641 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046790 Css NA 0.05848 mg/L PBTK NA 50% Rat Human -DTXSID3046790 Css NA 0.2939 mg/L PBTK NA 95% Rat Human -DTXSID3046792 Clint NA 55.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046792 Fup NA 0.0121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046792 Vd NA 2.572 L/kg 1compartment NA NA Human Human -DTXSID3046792 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046792 TK.Half.Life NA 7.238 hours 1compartment NA NA Human Human -DTXSID3046792 Css NA 0.3034 mg/L 3compartmentss NA 50% Human Human -DTXSID3046792 Css NA 2.376 mg/L 3compartmentss NA 95% Human Human -DTXSID3046792 Css NA 0.206 mg/L PBTK NA 50% Human Human -DTXSID3046792 Css NA 1.515 mg/L PBTK NA 95% Human Human -DTXSID3046792 Clint NA 55.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046792 Fup NA 0.0121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046792 Vd NA 1.985 L/kg 1compartment NA NA Rat Human -DTXSID3046792 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046792 TK.Half.Life NA 2.125 hours 1compartment NA NA Rat Human -DTXSID3046792 Css NA 0.1731 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046792 Css NA 1.116 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046792 Css NA 0.1109 mg/L PBTK NA 50% Rat Human -DTXSID3046792 Css NA 0.6968 mg/L PBTK NA 95% Rat Human -DTXSID3046796 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046796 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046796 Vd NA 0.2562 L/kg 1compartment NA NA Human Human +DTXSID3046790 TK.Half.Life NA 3.779 hours 1compartment NA NA Rat Human +DTXSID3046790 Css NA 0.09181 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046790 Css NA 0.4928 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046790 Css NA 0.06191 mg/L PBTK NA 50% Rat Human +DTXSID3046790 Css NA 0.3242 mg/L PBTK NA 95% Rat Human +DTXSID3046792 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046792 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046792 Vd NA 3.435 L/kg 1compartment NA NA Human Human +DTXSID3046792 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID3046792 TK.Half.Life NA 103.2 hours 1compartment NA NA Human Human +DTXSID3046792 Css NA 3.301 mg/L 3compartmentss NA 50% Human Human +DTXSID3046792 Css NA 19.3 mg/L 3compartmentss NA 95% Human Human +DTXSID3046792 Css NA 2.36 mg/L PBTK NA 50% Human Human +DTXSID3046792 Css NA 13.67 mg/L PBTK NA 95% Human Human +DTXSID3046792 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046792 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046792 Vd NA 2.582 L/kg 1compartment NA NA Rat Human +DTXSID3046792 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID3046792 TK.Half.Life NA 13.66 hours 1compartment NA NA Rat Human +DTXSID3046792 Css NA 0.4312 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046792 Css NA 2.158 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046792 Css NA 0.3061 mg/L PBTK NA 50% Rat Human +DTXSID3046792 Css NA 1.56 mg/L PBTK NA 95% Rat Human +DTXSID3046796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046796 Fup 0.0483 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046796 Vd NA 0.3448 L/kg 1compartment NA NA Human Human DTXSID3046796 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046796 TK.Half.Life NA 1.911 hours 1compartment NA NA Human Human -DTXSID3046796 Css NA 1.249 mg/L 3compartmentss NA 50% Human Human -DTXSID3046796 Css NA 12.54 mg/L 3compartmentss NA 95% Human Human -DTXSID3046796 Css NA 0.754 mg/L PBTK NA 50% Human Human -DTXSID3046796 Css NA 7.339 mg/L PBTK NA 95% Human Human -DTXSID3046796 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046796 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046796 Vd NA 0.2478 L/kg 1compartment NA NA Rat Human +DTXSID3046796 TK.Half.Life NA 1.546 hours 1compartment NA NA Human Human +DTXSID3046796 Css NA 0.3333 mg/L 3compartmentss NA 50% Human Human +DTXSID3046796 Css NA 3.121 mg/L 3compartmentss NA 95% Human Human +DTXSID3046796 Css NA 0.2068 mg/L PBTK NA 50% Human Human +DTXSID3046796 Css NA 1.873 mg/L PBTK NA 95% Human Human +DTXSID3046796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046796 Fup 0.0483 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046796 Vd NA 0.3366 L/kg 1compartment NA NA Rat Human DTXSID3046796 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046796 TK.Half.Life NA 1.215 hours 1compartment NA NA Rat Human -DTXSID3046796 Css NA 0.7193 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046796 Css NA 5.722 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046796 Css NA 0.402 mg/L PBTK NA 50% Rat Human -DTXSID3046796 Css NA 3.108 mg/L PBTK NA 95% Rat Human -DTXSID3046798 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046798 Fup NA 0.1967 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046798 Vd NA 3.481 L/kg 1compartment NA NA Human Human -DTXSID3046798 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID3046798 TK.Half.Life NA 122.2 hours 1compartment NA NA Human Human -DTXSID3046798 Css NA 2.545 mg/L 3compartmentss NA 50% Human Human -DTXSID3046798 Css NA 11.68 mg/L 3compartmentss NA 95% Human Human -DTXSID3046798 Css NA 2.87 mg/L PBTK NA 50% Human Human -DTXSID3046798 Css NA 9.608 mg/L PBTK NA 95% Human Human -DTXSID3046798 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046798 Fup NA 0.1967 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046798 Vd NA 3.496 L/kg 1compartment NA NA Rat Human -DTXSID3046798 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID3046798 TK.Half.Life NA 39.81 hours 1compartment NA NA Rat Human -DTXSID3046798 Css NA 0.6647 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046798 Css NA 2.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046798 Css NA 0.7511 mg/L PBTK NA 50% Rat Human -DTXSID3046798 Css NA 2.002 mg/L PBTK NA 95% Rat Human -DTXSID3046821 Clint NA 4.299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046821 Fup NA 0.539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046821 Vd NA 2.863 L/kg 1compartment NA NA Human Human +DTXSID3046796 TK.Half.Life NA 0.9523 hours 1compartment NA NA Rat Human +DTXSID3046796 Css NA 0.003634 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046796 Css NA 0.02945 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046796 Css NA 0.002124 mg/L PBTK NA 50% Rat Human +DTXSID3046796 Css NA 0.01645 mg/L PBTK NA 95% Rat Human +DTXSID3046798 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046798 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046798 Vd NA 3.438 L/kg 1compartment NA NA Human Human +DTXSID3046798 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3046798 TK.Half.Life NA 9.18 hours 1compartment NA NA Human Human +DTXSID3046798 Css NA 0.17 mg/L 3compartmentss NA 50% Human Human +DTXSID3046798 Css NA 1.326 mg/L 3compartmentss NA 95% Human Human +DTXSID3046798 Css NA 0.1901 mg/L PBTK NA 50% Human Human +DTXSID3046798 Css NA 1.178 mg/L PBTK NA 95% Human Human +DTXSID3046798 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046798 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046798 Vd NA 3.455 L/kg 1compartment NA NA Rat Human +DTXSID3046798 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3046798 TK.Half.Life NA 5.436 hours 1compartment NA NA Rat Human +DTXSID3046798 Css NA 0.02014 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046798 Css NA 0.1091 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046798 Css NA 0.02308 mg/L PBTK NA 50% Rat Human +DTXSID3046798 Css NA 0.09517 mg/L PBTK NA 95% Rat Human +DTXSID3046821 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046821 Fup 0.542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046821 Vd NA 2.072 L/kg 1compartment NA NA Human Human DTXSID3046821 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046821 TK.Half.Life NA 4.868 hours 1compartment NA NA Human Human -DTXSID3046821 Css NA 0.1074 mg/L 3compartmentss NA 50% Human Human -DTXSID3046821 Css NA 0.9931 mg/L 3compartmentss NA 95% Human Human -DTXSID3046821 Css NA 0.1312 mg/L PBTK NA 50% Human Human -DTXSID3046821 Css NA 0.8285 mg/L PBTK NA 95% Human Human -DTXSID3046821 Clint NA 4.299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046821 Fup NA 0.539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046821 Vd NA 2.845 L/kg 1compartment NA NA Rat Human +DTXSID3046821 TK.Half.Life NA 1.625 hours 1compartment NA NA Human Human +DTXSID3046821 Css NA 0.02728 mg/L 3compartmentss NA 50% Human Human +DTXSID3046821 Css NA 0.3049 mg/L 3compartmentss NA 95% Human Human +DTXSID3046821 Css NA 0.02786 mg/L PBTK NA 50% Human Human +DTXSID3046821 Css NA 0.242 mg/L PBTK NA 95% Human Human +DTXSID3046821 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046821 Fup 0.542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046821 Vd NA 2.052 L/kg 1compartment NA NA Rat Human DTXSID3046821 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046821 TK.Half.Life NA 2.765 hours 1compartment NA NA Rat Human -DTXSID3046821 Css NA 0.04945 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046821 Css NA 0.4264 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046821 Css NA 0.06041 mg/L PBTK NA 50% Rat Human -DTXSID3046821 Css NA 0.3089 mg/L PBTK NA 95% Rat Human -DTXSID3046823 Clint NA 13.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046823 Fup NA 0.0562 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046823 Vd NA 2.53 L/kg 1compartment NA NA Human Human -DTXSID3046823 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3046823 TK.Half.Life NA 25.81 hours 1compartment NA NA Human Human -DTXSID3046823 Css NA 1.354 mg/L 3compartmentss NA 50% Human Human -DTXSID3046823 Css NA 8.813 mg/L 3compartmentss NA 95% Human Human -DTXSID3046823 Css NA 0.912 mg/L PBTK NA 50% Human Human -DTXSID3046823 Css NA 5.692 mg/L PBTK NA 95% Human Human -DTXSID3046823 Clint NA 13.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046823 Fup NA 0.0562 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046823 Vd NA 1.897 L/kg 1compartment NA NA Rat Human -DTXSID3046823 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3046823 TK.Half.Life NA 6.307 hours 1compartment NA NA Rat Human -DTXSID3046823 Css NA 0.7465 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046823 Css NA 3.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046823 Css NA 0.4795 mg/L PBTK NA 50% Rat Human -DTXSID3046823 Css NA 2.247 mg/L PBTK NA 95% Rat Human -DTXSID3046825 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046825 Fup NA 0.6585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046825 Vd NA 0.735 L/kg 1compartment NA NA Human Human +DTXSID3046821 TK.Half.Life NA 0.8366 hours 1compartment NA NA Rat Human +DTXSID3046821 Css NA 0.003214 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046821 Css NA 0.03103 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046821 Css NA 0.003424 mg/L PBTK NA 50% Rat Human +DTXSID3046821 Css NA 0.02351 mg/L PBTK NA 95% Rat Human +DTXSID3046823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046823 Fup 0.0732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046823 Vd NA 2.651 L/kg 1compartment NA NA Human Human +DTXSID3046823 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3046823 TK.Half.Life NA 16.75 hours 1compartment NA NA Human Human +DTXSID3046823 Css NA 0.7311 mg/L 3compartmentss NA 50% Human Human +DTXSID3046823 Css NA 4.916 mg/L 3compartmentss NA 95% Human Human +DTXSID3046823 Css NA 0.5018 mg/L PBTK NA 50% Human Human +DTXSID3046823 Css NA 3.277 mg/L PBTK NA 95% Human Human +DTXSID3046823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046823 Fup 0.0732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046823 Vd NA 1.991 L/kg 1compartment NA NA Rat Human +DTXSID3046823 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3046823 TK.Half.Life NA 3.898 hours 1compartment NA NA Rat Human +DTXSID3046823 Css NA 0.09568 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046823 Css NA 0.5152 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046823 Css NA 0.06457 mg/L PBTK NA 50% Rat Human +DTXSID3046823 Css NA 0.3412 mg/L PBTK NA 95% Rat Human +DTXSID3046825 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046825 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046825 Vd NA 0.4565 L/kg 1compartment NA NA Human Human DTXSID3046825 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046825 TK.Half.Life NA 7.263 hours 1compartment NA NA Human Human -DTXSID3046825 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human -DTXSID3046825 Css NA 7.299 mg/L 3compartmentss NA 95% Human Human -DTXSID3046825 Css NA 0.9137 mg/L PBTK NA 50% Human Human -DTXSID3046825 Css NA 4.622 mg/L PBTK NA 95% Human Human -DTXSID3046825 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046825 Fup NA 0.6585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046825 Vd NA 0.738 L/kg 1compartment NA NA Rat Human +DTXSID3046825 TK.Half.Life NA 3.677 hours 1compartment NA NA Human Human +DTXSID3046825 Css NA 0.606 mg/L 3compartmentss NA 50% Human Human +DTXSID3046825 Css NA 3.401 mg/L 3compartmentss NA 95% Human Human +DTXSID3046825 Css NA 0.4459 mg/L PBTK NA 50% Human Human +DTXSID3046825 Css NA 2.15 mg/L PBTK NA 95% Human Human +DTXSID3046825 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046825 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046825 Vd NA 0.4768 L/kg 1compartment NA NA Rat Human DTXSID3046825 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046825 TK.Half.Life NA 2.475 hours 1compartment NA NA Rat Human -DTXSID3046825 Css NA 0.3022 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046825 Css NA 1.894 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046825 Css NA 0.234 mg/L PBTK NA 50% Rat Human -DTXSID3046825 Css NA 1.116 mg/L PBTK NA 95% Rat Human -DTXSID3046827 Clint NA 25.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046827 Fup NA 0.1007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046827 Vd NA 1.184 L/kg 1compartment NA NA Human Human +DTXSID3046825 TK.Half.Life NA 1.309 hours 1compartment NA NA Rat Human +DTXSID3046825 Css NA 0.003082 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046825 Css NA 0.01872 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046825 Css NA 0.002196 mg/L PBTK NA 50% Rat Human +DTXSID3046825 Css NA 0.01123 mg/L PBTK NA 95% Rat Human +DTXSID3046827 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046827 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046827 Vd NA 0.9425 L/kg 1compartment NA NA Human Human DTXSID3046827 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046827 TK.Half.Life NA 2.495 hours 1compartment NA NA Human Human -DTXSID3046827 Css NA 0.207 mg/L 3compartmentss NA 50% Human Human -DTXSID3046827 Css NA 1.77 mg/L 3compartmentss NA 95% Human Human -DTXSID3046827 Css NA 0.1468 mg/L PBTK NA 50% Human Human -DTXSID3046827 Css NA 1.146 mg/L PBTK NA 95% Human Human -DTXSID3046827 Clint NA 25.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046827 Fup NA 0.1007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046827 Vd NA 1.169 L/kg 1compartment NA NA Rat Human +DTXSID3046827 TK.Half.Life NA 1.691 hours 1compartment NA NA Human Human +DTXSID3046827 Css NA 0.1304 mg/L 3compartmentss NA 50% Human Human +DTXSID3046827 Css NA 1.009 mg/L 3compartmentss NA 95% Human Human +DTXSID3046827 Css NA 0.1058 mg/L PBTK NA 50% Human Human +DTXSID3046827 Css NA 0.6908 mg/L PBTK NA 95% Human Human +DTXSID3046827 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046827 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046827 Vd NA 0.9647 L/kg 1compartment NA NA Rat Human DTXSID3046827 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046827 TK.Half.Life NA 1.46 hours 1compartment NA NA Rat Human -DTXSID3046827 Css NA 0.1143 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046827 Css NA 0.7599 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046827 Css NA 0.07664 mg/L PBTK NA 50% Rat Human -DTXSID3046827 Css NA 0.46 mg/L PBTK NA 95% Rat Human -DTXSID3046829 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046829 Fup NA 0.9687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046829 Vd NA 0.6909 L/kg 1compartment NA NA Human Human -DTXSID3046829 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046829 TK.Half.Life NA 4.615 hours 1compartment NA NA Human Human -DTXSID3046829 Css NA 0.8654 mg/L 3compartmentss NA 50% Human Human -DTXSID3046829 Css NA 2.981 mg/L 3compartmentss NA 95% Human Human -DTXSID3046829 Css NA 0.7092 mg/L PBTK NA 50% Human Human -DTXSID3046829 Css NA 2.058 mg/L PBTK NA 95% Human Human -DTXSID3046829 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046829 Fup NA 0.9687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046829 Vd NA 0.7392 L/kg 1compartment NA NA Rat Human -DTXSID3046829 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046829 TK.Half.Life NA 1.683 hours 1compartment NA NA Rat Human -DTXSID3046829 Css NA 0.221 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046829 Css NA 0.668 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046829 Css NA 0.177 mg/L PBTK NA 50% Rat Human -DTXSID3046829 Css NA 0.4321 mg/L PBTK NA 95% Rat Human -DTXSID3046871 Clint NA 0.8533 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046871 Fup NA 0.2403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046871 Vd NA 0.3089 L/kg 1compartment NA NA Human Human +DTXSID3046827 TK.Half.Life NA 0.9648 hours 1compartment NA NA Rat Human +DTXSID3046827 Css NA 0.01525 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046827 Css NA 0.08916 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046827 Css NA 0.01232 mg/L PBTK NA 50% Rat Human +DTXSID3046827 Css NA 0.0588 mg/L PBTK NA 95% Rat Human +DTXSID30468614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30468614 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30468614 Vd NA 2.711 L/kg 1compartment NA NA Human Human +DTXSID30468614 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID30468614 TK.Half.Life NA 34.11 hours 1compartment NA NA Human Human +DTXSID30468614 Css NA 1.668 mg/L 3compartmentss NA 50% Human Human +DTXSID30468614 Css NA 11.61 mg/L 3compartmentss NA 95% Human Human +DTXSID30468614 Css NA 1.12 mg/L PBTK NA 50% Human Human +DTXSID30468614 Css NA 7.46 mg/L PBTK NA 95% Human Human +DTXSID30468614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30468614 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30468614 Vd NA 2.027 L/kg 1compartment NA NA Rat Human +DTXSID30468614 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID30468614 TK.Half.Life NA 7.265 hours 1compartment NA NA Rat Human +DTXSID30468614 Css NA 0.2152 mg/L 3compartmentss NA 50% Rat Human +DTXSID30468614 Css NA 1.274 mg/L 3compartmentss NA 95% Rat Human +DTXSID30468614 Css NA 0.1426 mg/L PBTK NA 50% Rat Human +DTXSID30468614 Css NA 0.8125 mg/L PBTK NA 95% Rat Human +DTXSID3046871 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046871 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046871 Vd NA 0.4333 L/kg 1compartment NA NA Human Human DTXSID3046871 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046871 TK.Half.Life NA 3.535 hours 1compartment NA NA Human Human -DTXSID3046871 Css NA 1.408 mg/L 3compartmentss NA 50% Human Human -DTXSID3046871 Css NA 5.939 mg/L 3compartmentss NA 95% Human Human -DTXSID3046871 Css NA 0.9108 mg/L PBTK NA 50% Human Human -DTXSID3046871 Css NA 3.548 mg/L PBTK NA 95% Human Human -DTXSID3046871 Clint NA 0.8533 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046871 Fup NA 0.2403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046871 Vd NA 0.3113 L/kg 1compartment NA NA Rat Human +DTXSID3046871 TK.Half.Life NA 6.261 hours 1compartment NA NA Human Human +DTXSID3046871 Css NA 1.641 mg/L 3compartmentss NA 50% Human Human +DTXSID3046871 Css NA 7.481 mg/L 3compartmentss NA 95% Human Human +DTXSID3046871 Css NA 1.18 mg/L PBTK NA 50% Human Human +DTXSID3046871 Css NA 4.663 mg/L PBTK NA 95% Human Human +DTXSID3046871 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046871 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046871 Vd NA 0.4368 L/kg 1compartment NA NA Rat Human DTXSID3046871 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046871 TK.Half.Life NA 1.712 hours 1compartment NA NA Rat Human -DTXSID3046871 Css NA 0.5634 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046871 Css NA 1.855 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046871 Css NA 0.3456 mg/L PBTK NA 50% Rat Human -DTXSID3046871 Css NA 1.053 mg/L PBTK NA 95% Rat Human -DTXSID3046875 Clint NA 12.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046875 Fup NA 0.4321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046875 Vd NA 0.6866 L/kg 1compartment NA NA Human Human +DTXSID3046871 TK.Half.Life NA 2.151 hours 1compartment NA NA Rat Human +DTXSID3046871 Css NA 0.1048 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046871 Css NA 0.4113 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046871 Css NA 0.07396 mg/L PBTK NA 50% Rat Human +DTXSID3046871 Css NA 0.248 mg/L PBTK NA 95% Rat Human +DTXSID3046875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046875 Fup 0.439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046875 Vd NA 0.6931 L/kg 1compartment NA NA Human Human DTXSID3046875 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046875 TK.Half.Life NA 0.9233 hours 1compartment NA NA Human Human -DTXSID3046875 Css NA 0.0836 mg/L 3compartmentss NA 50% Human Human -DTXSID3046875 Css NA 0.6228 mg/L 3compartmentss NA 95% Human Human -DTXSID3046875 Css NA 0.06288 mg/L PBTK NA 50% Human Human -DTXSID3046875 Css NA 0.4222 mg/L PBTK NA 95% Human Human -DTXSID3046875 Clint NA 12.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046875 Fup NA 0.4321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046875 Vd NA 0.6675 L/kg 1compartment NA NA Rat Human +DTXSID3046875 TK.Half.Life NA 0.7394 hours 1compartment NA NA Human Human +DTXSID3046875 Css NA 0.04413 mg/L 3compartmentss NA 50% Human Human +DTXSID3046875 Css NA 0.3623 mg/L 3compartmentss NA 95% Human Human +DTXSID3046875 Css NA 0.03318 mg/L PBTK NA 50% Human Human +DTXSID3046875 Css NA 0.2481 mg/L PBTK NA 95% Human Human +DTXSID3046875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046875 Fup 0.439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046875 Vd NA 0.6737 L/kg 1compartment NA NA Rat Human DTXSID3046875 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046875 TK.Half.Life NA 0.48 hours 1compartment NA NA Rat Human -DTXSID3046875 Css NA 0.04267 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046875 Css NA 0.2529 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046875 Css NA 0.03114 mg/L PBTK NA 50% Rat Human -DTXSID3046875 Css NA 0.1593 mg/L PBTK NA 95% Rat Human -DTXSID3046879 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046879 Fup NA 0.0328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046879 Vd NA 1.727 L/kg 1compartment NA NA Human Human -DTXSID3046879 Days.Css NA 135 Days PBTK NA NA Human Human -DTXSID3046879 TK.Half.Life NA 549.2 hours 1compartment NA NA Human Human -DTXSID3046879 Css NA 48.14 mg/L 3compartmentss NA 50% Human Human -DTXSID3046879 Css NA 215.6 mg/L 3compartmentss NA 95% Human Human -DTXSID3046879 Css NA 30.74 mg/L PBTK NA 50% Human Human -DTXSID3046879 Css NA 130.3 mg/L PBTK NA 95% Human Human -DTXSID3046879 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046879 Fup NA 0.0328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046879 Vd NA 1.288 L/kg 1compartment NA NA Rat Human -DTXSID3046879 Days.Css NA 31 Days PBTK NA NA Rat Human -DTXSID3046879 TK.Half.Life NA 99.22 hours 1compartment NA NA Rat Human -DTXSID3046879 Css NA 13.54 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046879 Css NA 53.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046879 Css NA 8.131 mg/L PBTK NA 50% Rat Human -DTXSID3046879 Css NA 29.64 mg/L PBTK NA 95% Rat Human +DTXSID3046875 TK.Half.Life NA 0.3666 hours 1compartment NA NA Rat Human +DTXSID3046875 Css NA 0.005331 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046875 Css NA 0.03621 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046875 Css NA 0.004085 mg/L PBTK NA 50% Rat Human +DTXSID3046875 Css NA 0.02382 mg/L PBTK NA 95% Rat Human +DTXSID3046879 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046879 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046879 Vd NA 1.687 L/kg 1compartment NA NA Human Human +DTXSID3046879 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3046879 TK.Half.Life NA 20.57 hours 1compartment NA NA Human Human +DTXSID3046879 Css NA 1.897 mg/L 3compartmentss NA 50% Human Human +DTXSID3046879 Css NA 15.84 mg/L 3compartmentss NA 95% Human Human +DTXSID3046879 Css NA 1.199 mg/L PBTK NA 50% Human Human +DTXSID3046879 Css NA 9.629 mg/L PBTK NA 95% Human Human +DTXSID3046879 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046879 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046879 Vd NA 1.249 L/kg 1compartment NA NA Rat Human +DTXSID3046879 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3046879 TK.Half.Life NA 7.451 hours 1compartment NA NA Rat Human +DTXSID3046879 Css NA 0.2462 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046879 Css NA 1.783 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046879 Css NA 0.1505 mg/L PBTK NA 50% Rat Human +DTXSID3046879 Css NA 1.055 mg/L PBTK NA 95% Rat Human DTXSID3046902 Clint NA 53.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3046902 Fup NA 0.1175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046902 Vd NA 0.3539 L/kg 1compartment NA NA Human Human +DTXSID3046902 Vd NA 0.3669 L/kg 1compartment NA NA Human Human DTXSID3046902 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046902 TK.Half.Life NA 0.5212 hours 1compartment NA NA Human Human -DTXSID3046902 Css NA 0.1025 mg/L 3compartmentss NA 50% Human Human -DTXSID3046902 Css NA 0.8638 mg/L 3compartmentss NA 95% Human Human -DTXSID3046902 Css NA 0.06551 mg/L PBTK NA 50% Human Human -DTXSID3046902 Css NA 0.5255 mg/L PBTK NA 95% Human Human +DTXSID3046902 TK.Half.Life NA 0.5466 hours 1compartment NA NA Human Human +DTXSID3046902 Css NA 0.09784 mg/L 3compartmentss NA 50% Human Human +DTXSID3046902 Css NA 0.8601 mg/L 3compartmentss NA 95% Human Human +DTXSID3046902 Css NA 0.06106 mg/L PBTK NA 50% Human Human +DTXSID3046902 Css NA 0.5207 mg/L PBTK NA 95% Human Human DTXSID3046902 Clint NA 53.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3046902 Fup NA 0.1175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046902 Vd NA 0.3515 L/kg 1compartment NA NA Rat Human +DTXSID3046902 Vd NA 0.3504 L/kg 1compartment NA NA Rat Human DTXSID3046902 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046902 TK.Half.Life NA 0.2789 hours 1compartment NA NA Rat Human -DTXSID3046902 Css NA 0.05772 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046902 Css NA 0.3826 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046902 Css NA 0.03454 mg/L PBTK NA 50% Rat Human -DTXSID3046902 Css NA 0.2176 mg/L PBTK NA 95% Rat Human -DTXSID3046904 Clint NA 32.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046904 Fup NA 0.0864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046904 Vd NA 11.46 L/kg 1compartment NA NA Human Human +DTXSID3046902 TK.Half.Life NA 0.2799 hours 1compartment NA NA Rat Human +DTXSID3046902 Css NA 0.01296 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046902 Css NA 0.09079 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046902 Css NA 0.00789 mg/L PBTK NA 50% Rat Human +DTXSID3046902 Css NA 0.05315 mg/L PBTK NA 95% Rat Human +DTXSID3046904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046904 Fup 0.0861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046904 Vd NA 3.685 L/kg 1compartment NA NA Human Human DTXSID3046904 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3046904 TK.Half.Life NA 7.896 hours 1compartment NA NA Human Human -DTXSID3046904 Css NA 0.02005 mg/L 3compartmentss NA 50% Human Human -DTXSID3046904 Css NA 0.1537 mg/L 3compartmentss NA 95% Human Human -DTXSID3046904 Css NA 0.02874 mg/L PBTK NA 50% Human Human -DTXSID3046904 Css NA 0.1824 mg/L PBTK NA 95% Human Human -DTXSID3046904 Clint NA 32.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046904 Fup NA 0.0864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046904 Vd NA 9.347 L/kg 1compartment NA NA Rat Human +DTXSID3046904 TK.Half.Life NA 4.365 hours 1compartment NA NA Human Human +DTXSID3046904 Css NA 0.06604 mg/L 3compartmentss NA 50% Human Human +DTXSID3046904 Css NA 0.617 mg/L 3compartmentss NA 95% Human Human +DTXSID3046904 Css NA 0.06392 mg/L PBTK NA 50% Human Human +DTXSID3046904 Css NA 0.5012 mg/L PBTK NA 95% Human Human +DTXSID3046904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046904 Fup 0.0861 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046904 Vd NA 3.457 L/kg 1compartment NA NA Rat Human DTXSID3046904 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3046904 TK.Half.Life NA 2.167 hours 1compartment NA NA Rat Human -DTXSID3046904 Css NA 0.01059 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046904 Css NA 0.06758 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046904 Css NA 0.01541 mg/L PBTK NA 50% Rat Human -DTXSID3046904 Css NA 0.08346 mg/L PBTK NA 95% Rat Human -DTXSID3046906 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046906 Fup NA 0.0339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046906 Vd NA 0.2385 L/kg 1compartment NA NA Human Human -DTXSID3046906 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID3046906 TK.Half.Life NA 45.54 hours 1compartment NA NA Human Human -DTXSID3046906 Css NA 34.33 mg/L 3compartmentss NA 50% Human Human -DTXSID3046906 Css NA 150.7 mg/L 3compartmentss NA 95% Human Human -DTXSID3046906 Css NA 20.48 mg/L PBTK NA 50% Human Human -DTXSID3046906 Css NA 88.41 mg/L PBTK NA 95% Human Human -DTXSID3046906 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046906 Fup NA 0.0339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046906 Vd NA 0.2323 L/kg 1compartment NA NA Rat Human -DTXSID3046906 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3046906 TK.Half.Life NA 15.1 hours 1compartment NA NA Rat Human -DTXSID3046906 Css NA 9.563 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046906 Css NA 36.58 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046906 Css NA 5.34 mg/L PBTK NA 50% Rat Human -DTXSID3046906 Css NA 19.93 mg/L PBTK NA 95% Rat Human +DTXSID3046904 TK.Half.Life NA 1.962 hours 1compartment NA NA Rat Human +DTXSID3046904 Css NA 0.00852 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046904 Css NA 0.06463 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046904 Css NA 0.008375 mg/L PBTK NA 50% Rat Human +DTXSID3046904 Css NA 0.05376 mg/L PBTK NA 95% Rat Human +DTXSID3046906 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046906 Fup 0.0623 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3046906 Vd NA 0.3507 L/kg 1compartment NA NA Human Human +DTXSID3046906 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3046906 TK.Half.Life NA 1.275 hours 1compartment NA NA Human Human +DTXSID3046906 Css NA 0.2276 mg/L 3compartmentss NA 50% Human Human +DTXSID3046906 Css NA 1.878 mg/L 3compartmentss NA 95% Human Human +DTXSID3046906 Css NA 0.1432 mg/L PBTK NA 50% Human Human +DTXSID3046906 Css NA 1.153 mg/L PBTK NA 95% Human Human +DTXSID3046906 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046906 Fup 0.0623 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3046906 Vd NA 0.3372 L/kg 1compartment NA NA Rat Human +DTXSID3046906 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3046906 TK.Half.Life NA 0.7601 hours 1compartment NA NA Rat Human +DTXSID3046906 Css NA 0.002424 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046906 Css NA 0.0168 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046906 Css NA 0.001435 mg/L PBTK NA 50% Rat Human +DTXSID3046906 Css NA 0.009603 mg/L PBTK NA 95% Rat Human DTXSID3046908 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3046908 Fup NA 0.021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3046908 Vd NA 1.822 L/kg 1compartment NA NA Human Human -DTXSID3046908 Days.Css NA 244 Days PBTK NA NA Human Human -DTXSID3046908 TK.Half.Life NA 954.6 hours 1compartment NA NA Human Human -DTXSID3046908 Css NA 78.1 mg/L 3compartmentss NA 50% Human Human -DTXSID3046908 Css NA 372.2 mg/L 3compartmentss NA 95% Human Human -DTXSID3046908 Css NA 50.11 mg/L PBTK NA 50% Human Human -DTXSID3046908 Css NA 220.3 mg/L PBTK NA 95% Human Human +DTXSID3046908 Vd NA 0.189 L/kg 1compartment NA NA Human Human +DTXSID3046908 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID3046908 TK.Half.Life NA 58.25 hours 1compartment NA NA Human Human +DTXSID3046908 Css NA 28.5 mg/L 3compartmentss NA 50% Human Human +DTXSID3046908 Css NA 183.7 mg/L 3compartmentss NA 95% Human Human +DTXSID3046908 Css NA 16.7 mg/L PBTK NA 50% Human Human +DTXSID3046908 Css NA 105.6 mg/L PBTK NA 95% Human Human DTXSID3046908 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3046908 Fup NA 0.021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3046908 Vd NA 1.361 L/kg 1compartment NA NA Rat Human -DTXSID3046908 Days.Css NA 58 Days PBTK NA NA Rat Human -DTXSID3046908 TK.Half.Life NA 166.8 hours 1compartment NA NA Rat Human -DTXSID3046908 Css NA 22.05 mg/L 3compartmentss NA 50% Rat Human -DTXSID3046908 Css NA 88.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID3046908 Css NA 13.23 mg/L PBTK NA 50% Rat Human -DTXSID3046908 Css NA 49 mg/L PBTK NA 95% Rat Human -DTXSID3047003 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047003 Fup NA 0.3934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047003 Vd NA 0.443 L/kg 1compartment NA NA Human Human -DTXSID3047003 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047003 TK.Half.Life NA 7.285 hours 1compartment NA NA Human Human -DTXSID3047003 Css NA 1.89 mg/L 3compartmentss NA 50% Human Human -DTXSID3047003 Css NA 8.172 mg/L 3compartmentss NA 95% Human Human -DTXSID3047003 Css NA 1.352 mg/L PBTK NA 50% Human Human -DTXSID3047003 Css NA 5.126 mg/L PBTK NA 95% Human Human -DTXSID3047003 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047003 Fup NA 0.3934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047003 Vd NA 0.4597 L/kg 1compartment NA NA Rat Human -DTXSID3047003 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047003 TK.Half.Life NA 2.576 hours 1compartment NA NA Rat Human -DTXSID3047003 Css NA 0.5226 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047003 Css NA 1.896 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047003 Css NA 0.3554 mg/L PBTK NA 50% Rat Human -DTXSID3047003 Css NA 1.109 mg/L PBTK NA 95% Rat Human -DTXSID3047051 Clint NA 2.075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047051 Fup NA 0.1596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047051 Vd NA 3.107 L/kg 1compartment NA NA Human Human -DTXSID3047051 Days.Css NA 94 Days PBTK NA NA Human Human -DTXSID3047051 TK.Half.Life NA 412.1 hours 1compartment NA NA Human Human -DTXSID3047051 Css NA 16.27 mg/L 3compartmentss NA 50% Human Human -DTXSID3047051 Css NA 81.68 mg/L 3compartmentss NA 95% Human Human -DTXSID3047051 Css NA 11.36 mg/L PBTK NA 50% Human Human -DTXSID3047051 Css NA 54.5 mg/L PBTK NA 95% Human Human -DTXSID3047051 Clint NA 2.075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047051 Fup NA 0.1596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047051 Vd NA 2.332 L/kg 1compartment NA NA Rat Human -DTXSID3047051 Days.Css NA 48 Days PBTK NA NA Rat Human -DTXSID3047051 TK.Half.Life NA 51.88 hours 1compartment NA NA Rat Human -DTXSID3047051 Css NA 8.438 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047051 Css NA 30.64 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047051 Css NA 5.68 mg/L PBTK NA 50% Rat Human -DTXSID3047051 Css NA 19.48 mg/L PBTK NA 95% Rat Human -DTXSID3047132 Clint NA 6.095 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047132 Fup NA 0.5137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047132 Vd NA 0.9378 L/kg 1compartment NA NA Human Human +DTXSID3046908 Vd NA 0.1839 L/kg 1compartment NA NA Rat Human +DTXSID3046908 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3046908 TK.Half.Life NA 19.31 hours 1compartment NA NA Rat Human +DTXSID3046908 Css NA 0.1572 mg/L 3compartmentss NA 50% Rat Human +DTXSID3046908 Css NA 0.984 mg/L 3compartmentss NA 95% Rat Human +DTXSID3046908 Css NA 0.08614 mg/L PBTK NA 50% Rat Human +DTXSID3046908 Css NA 0.5348 mg/L PBTK NA 95% Rat Human +DTXSID3047001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047001 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047001 Vd NA 1.73 L/kg 1compartment NA NA Human Human +DTXSID3047001 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3047001 TK.Half.Life NA 2.321 hours 1compartment NA NA Human Human +DTXSID3047001 Css NA 0.07265 mg/L 3compartmentss NA 50% Human Human +DTXSID3047001 Css NA 0.5199 mg/L 3compartmentss NA 95% Human Human +DTXSID3047001 Css NA 0.05615 mg/L PBTK NA 50% Human Human +DTXSID3047001 Css NA 0.3684 mg/L PBTK NA 95% Human Human +DTXSID3047001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047001 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047001 Vd NA 1.387 L/kg 1compartment NA NA Rat Human +DTXSID3047001 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3047001 TK.Half.Life NA 0.8756 hours 1compartment NA NA Rat Human +DTXSID3047001 Css NA 0.009022 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047001 Css NA 0.05141 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047001 Css NA 0.007021 mg/L PBTK NA 50% Rat Human +DTXSID3047001 Css NA 0.0366 mg/L PBTK NA 95% Rat Human +DTXSID3047059 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047059 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047059 Vd NA 1.844 L/kg 1compartment NA NA Human Human +DTXSID3047059 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3047059 TK.Half.Life NA 4.404 hours 1compartment NA NA Human Human +DTXSID3047059 Css NA 0.2187 mg/L 3compartmentss NA 50% Human Human +DTXSID3047059 Css NA 1.599 mg/L 3compartmentss NA 95% Human Human +DTXSID3047059 Css NA 0.1512 mg/L PBTK NA 50% Human Human +DTXSID3047059 Css NA 1.03 mg/L PBTK NA 95% Human Human +DTXSID3047059 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047059 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047059 Vd NA 1.415 L/kg 1compartment NA NA Rat Human +DTXSID3047059 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3047059 TK.Half.Life NA 1.56 hours 1compartment NA NA Rat Human +DTXSID3047059 Css NA 0.02817 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047059 Css NA 0.1579 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047059 Css NA 0.01936 mg/L PBTK NA 50% Rat Human +DTXSID3047059 Css NA 0.1025 mg/L PBTK NA 95% Rat Human +DTXSID3047130 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047130 Fup 0.084 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047130 Vd NA 2.305 L/kg 1compartment NA NA Human Human +DTXSID3047130 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3047130 TK.Half.Life NA 10.05 hours 1compartment NA NA Human Human +DTXSID3047130 Css NA 0.5042 mg/L 3compartmentss NA 50% Human Human +DTXSID3047130 Css NA 3.417 mg/L 3compartmentss NA 95% Human Human +DTXSID3047130 Css NA 0.3412 mg/L PBTK NA 50% Human Human +DTXSID3047130 Css NA 2.256 mg/L PBTK NA 95% Human Human +DTXSID3047130 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047130 Fup 0.084 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047130 Vd NA 1.736 L/kg 1compartment NA NA Rat Human +DTXSID3047130 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3047130 TK.Half.Life NA 2.907 hours 1compartment NA NA Rat Human +DTXSID3047130 Css NA 0.06508 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047130 Css NA 0.33 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047130 Css NA 0.04348 mg/L PBTK NA 50% Rat Human +DTXSID3047130 Css NA 0.2123 mg/L PBTK NA 95% Rat Human +DTXSID3047132 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047132 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047132 Vd NA 1.417 L/kg 1compartment NA NA Human Human DTXSID3047132 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047132 TK.Half.Life NA 1.595 hours 1compartment NA NA Human Human -DTXSID3047132 Css NA 0.1301 mg/L 3compartmentss NA 50% Human Human -DTXSID3047132 Css NA 0.977 mg/L 3compartmentss NA 95% Human Human -DTXSID3047132 Css NA 0.1052 mg/L PBTK NA 50% Human Human -DTXSID3047132 Css NA 0.6699 mg/L PBTK NA 95% Human Human -DTXSID3047132 Clint NA 6.095 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047132 Fup NA 0.5137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047132 Vd NA 0.8809 L/kg 1compartment NA NA Rat Human +DTXSID3047132 TK.Half.Life NA 2.187 hours 1compartment NA NA Human Human +DTXSID3047132 Css NA 0.0972 mg/L 3compartmentss NA 50% Human Human +DTXSID3047132 Css NA 0.659 mg/L 3compartmentss NA 95% Human Human +DTXSID3047132 Css NA 0.07048 mg/L PBTK NA 50% Human Human +DTXSID3047132 Css NA 0.4552 mg/L PBTK NA 95% Human Human +DTXSID3047132 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047132 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047132 Vd NA 1.138 L/kg 1compartment NA NA Rat Human DTXSID3047132 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047132 TK.Half.Life NA 0.8115 hours 1compartment NA NA Rat Human -DTXSID3047132 Css NA 0.06471 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047132 Css NA 0.3852 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047132 Css NA 0.05075 mg/L PBTK NA 50% Rat Human -DTXSID3047132 Css NA 0.2437 mg/L PBTK NA 95% Rat Human -DTXSID3047180 Clint NA 1707 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047180 Fup NA 0.0027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047180 Vd NA 206700 L/kg 1compartment NA NA Human Human -DTXSID3047180 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID3047180 TK.Half.Life NA 80530 hours 1compartment NA NA Human Human -DTXSID3047180 Css NA 7.89e-07 mg/L 3compartmentss NA 50% Human Human -DTXSID3047180 Css NA 4.814e-06 mg/L 3compartmentss NA 95% Human Human -DTXSID3047180 Css NA 0.03266 mg/L PBTK NA 50% Human Human -DTXSID3047180 Css NA 0.1821 mg/L PBTK NA 95% Human Human -DTXSID3047180 Clint NA 1707 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047180 Fup NA 0.0027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047180 Vd NA 197000 L/kg 1compartment NA NA Rat Human -DTXSID3047180 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID3047180 TK.Half.Life NA 14830 hours 1compartment NA NA Rat Human -DTXSID3047180 Css NA 4.01e-07 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047180 Css NA 1.674e-06 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047180 Css NA 0.01763 mg/L PBTK NA 50% Rat Human -DTXSID3047180 Css NA 0.07174 mg/L PBTK NA 95% Rat Human -DTXSID3047182 Clint NA 82.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047182 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047182 Vd NA 8.067 L/kg 1compartment NA NA Human Human -DTXSID3047182 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID3047182 TK.Half.Life NA 67.04 hours 1compartment NA NA Human Human -DTXSID3047182 Css NA 0.6222 mg/L 3compartmentss NA 50% Human Human -DTXSID3047182 Css NA 3.695 mg/L 3compartmentss NA 95% Human Human -DTXSID3047182 Css NA 0.644 mg/L PBTK NA 50% Human Human -DTXSID3047182 Css NA 3.666 mg/L PBTK NA 95% Human Human -DTXSID3047182 Clint NA 82.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047182 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047182 Vd NA 6.288 L/kg 1compartment NA NA Rat Human -DTXSID3047182 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID3047182 TK.Half.Life NA 9.988 hours 1compartment NA NA Rat Human -DTXSID3047182 Css NA 0.3409 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047182 Css NA 1.481 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047182 Css NA 0.348 mg/L PBTK NA 50% Rat Human -DTXSID3047182 Css NA 1.513 mg/L PBTK NA 95% Rat Human -DTXSID3047184 Clint NA 7.409 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047184 Fup NA 0.2091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047184 Vd NA 2.152 L/kg 1compartment NA NA Human Human +DTXSID3047132 TK.Half.Life NA 0.8782 hours 1compartment NA NA Rat Human +DTXSID3047132 Css NA 0.01194 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047132 Css NA 0.06306 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047132 Css NA 0.008724 mg/L PBTK NA 50% Rat Human +DTXSID3047132 Css NA 0.04294 mg/L PBTK NA 95% Rat Human +DTXSID3047182 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047182 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047182 Vd NA 59.65 L/kg 1compartment NA NA Human Human +DTXSID3047182 Days.Css NA 448 Days PBTK NA NA Human Human +DTXSID3047182 TK.Half.Life NA 1759 hours 1compartment NA NA Human Human +DTXSID3047182 Css NA 0.1919 mg/L 3compartmentss NA 50% Human Human +DTXSID3047182 Css NA 1.339 mg/L 3compartmentss NA 95% Human Human +DTXSID3047182 Css NA 1.306 mg/L PBTK NA 50% Human Human +DTXSID3047182 Css NA 8.228 mg/L PBTK NA 95% Human Human +DTXSID3047182 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047182 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047182 Vd NA 50.63 L/kg 1compartment NA NA Rat Human +DTXSID3047182 Days.Css NA 277 Days PBTK NA NA Rat Human +DTXSID3047182 TK.Half.Life NA 258.6 hours 1compartment NA NA Rat Human +DTXSID3047182 Css NA 0.001908 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047182 Css NA 0.01147 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047182 Css NA 0.01382 mg/L PBTK NA 50% Rat Human +DTXSID3047182 Css NA 0.08305 mg/L PBTK NA 95% Rat Human +DTXSID3047184 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047184 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047184 Vd NA 1.603 L/kg 1compartment NA NA Human Human DTXSID3047184 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047184 TK.Half.Life NA 9.782 hours 1compartment NA NA Human Human -DTXSID3047184 Css NA 0.4662 mg/L 3compartmentss NA 50% Human Human -DTXSID3047184 Css NA 2.548 mg/L 3compartmentss NA 95% Human Human -DTXSID3047184 Css NA 0.3383 mg/L PBTK NA 50% Human Human -DTXSID3047184 Css NA 1.754 mg/L PBTK NA 95% Human Human -DTXSID3047184 Clint NA 7.409 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047184 Fup NA 0.2091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047184 Vd NA 1.654 L/kg 1compartment NA NA Rat Human +DTXSID3047184 TK.Half.Life NA 4.401 hours 1compartment NA NA Human Human +DTXSID3047184 Css NA 0.2863 mg/L 3compartmentss NA 50% Human Human +DTXSID3047184 Css NA 2.137 mg/L 3compartmentss NA 95% Human Human +DTXSID3047184 Css NA 0.191 mg/L PBTK NA 50% Human Human +DTXSID3047184 Css NA 1.363 mg/L PBTK NA 95% Human Human +DTXSID3047184 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047184 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047184 Vd NA 1.227 L/kg 1compartment NA NA Rat Human DTXSID3047184 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047184 TK.Half.Life NA 3.045 hours 1compartment NA NA Rat Human -DTXSID3047184 Css NA 0.2426 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047184 Css NA 0.9916 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047184 Css NA 0.1704 mg/L PBTK NA 50% Rat Human -DTXSID3047184 Css NA 0.6409 mg/L PBTK NA 95% Rat Human -DTXSID3047186 Clint NA 170.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047186 Fup NA 0.0766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047186 Vd NA 2.061 L/kg 1compartment NA NA Human Human -DTXSID3047186 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047186 TK.Half.Life NA 2.605 hours 1compartment NA NA Human Human -DTXSID3047186 Css NA 0.06574 mg/L 3compartmentss NA 50% Human Human -DTXSID3047186 Css NA 0.4911 mg/L 3compartmentss NA 95% Human Human -DTXSID3047186 Css NA 0.04379 mg/L PBTK NA 50% Human Human -DTXSID3047186 Css NA 0.3153 mg/L PBTK NA 95% Human Human -DTXSID3047186 Clint NA 170.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047186 Fup NA 0.0766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047186 Vd NA 1.55 L/kg 1compartment NA NA Rat Human -DTXSID3047186 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047186 TK.Half.Life NA 0.8507 hours 1compartment NA NA Rat Human -DTXSID3047186 Css NA 0.03722 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047186 Css NA 0.2265 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047186 Css NA 0.0236 mg/L PBTK NA 50% Rat Human -DTXSID3047186 Css NA 0.1395 mg/L PBTK NA 95% Rat Human -DTXSID3047261 Clint NA 0.1206 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047261 Fup NA 0.0392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047261 Vd NA 0.3062 L/kg 1compartment NA NA Human Human -DTXSID3047261 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID3047261 TK.Half.Life NA 42.14 hours 1compartment NA NA Human Human -DTXSID3047261 Css NA 22.96 mg/L 3compartmentss NA 50% Human Human -DTXSID3047261 Css NA 133.7 mg/L 3compartmentss NA 95% Human Human -DTXSID3047261 Css NA 13.98 mg/L PBTK NA 50% Human Human -DTXSID3047261 Css NA 78.62 mg/L PBTK NA 95% Human Human -DTXSID3047261 Clint NA 0.1206 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047261 Fup NA 0.0392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047261 Vd NA 0.2988 L/kg 1compartment NA NA Rat Human -DTXSID3047261 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3047261 TK.Half.Life NA 15.32 hours 1compartment NA NA Rat Human -DTXSID3047261 Css NA 7.284 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047261 Css NA 38.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047261 Css NA 4.152 mg/L PBTK NA 50% Rat Human -DTXSID3047261 Css NA 20.75 mg/L PBTK NA 95% Rat Human -DTXSID3047263 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047263 Fup NA 0.1831 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047263 Vd NA 0.7738 L/kg 1compartment NA NA Human Human -DTXSID3047263 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3047263 TK.Half.Life NA 28.86 hours 1compartment NA NA Human Human -DTXSID3047263 Css NA 4.454 mg/L 3compartmentss NA 50% Human Human -DTXSID3047263 Css NA 15.83 mg/L 3compartmentss NA 95% Human Human -DTXSID3047263 Css NA 3.028 mg/L PBTK NA 50% Human Human -DTXSID3047263 Css NA 9.844 mg/L PBTK NA 95% Human Human -DTXSID3047263 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047263 Fup NA 0.1831 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047263 Vd NA 0.6615 L/kg 1compartment NA NA Rat Human +DTXSID3047184 TK.Half.Life NA 1.661 hours 1compartment NA NA Rat Human +DTXSID3047184 Css NA 0.03722 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047184 Css NA 0.2177 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047184 Css NA 0.02442 mg/L PBTK NA 50% Rat Human +DTXSID3047184 Css NA 0.136 mg/L PBTK NA 95% Rat Human +DTXSID3047186 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047186 Fup 0.0863 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047186 Vd NA 2.827 L/kg 1compartment NA NA Human Human +DTXSID3047186 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3047186 TK.Half.Life NA 20.37 hours 1compartment NA NA Human Human +DTXSID3047186 Css NA 0.8304 mg/L 3compartmentss NA 50% Human Human +DTXSID3047186 Css NA 5.458 mg/L 3compartmentss NA 95% Human Human +DTXSID3047186 Css NA 0.5737 mg/L PBTK NA 50% Human Human +DTXSID3047186 Css NA 3.617 mg/L PBTK NA 95% Human Human +DTXSID3047186 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047186 Fup 0.0863 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047186 Vd NA 2.122 L/kg 1compartment NA NA Rat Human +DTXSID3047186 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3047186 TK.Half.Life NA 4.106 hours 1compartment NA NA Rat Human +DTXSID3047186 Css NA 0.106 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047186 Css NA 0.5908 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047186 Css NA 0.07253 mg/L PBTK NA 50% Rat Human +DTXSID3047186 Css NA 0.3959 mg/L PBTK NA 95% Rat Human +DTXSID3047217 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047217 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047217 Vd NA 1.121 L/kg 1compartment NA NA Human Human +DTXSID3047217 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3047217 TK.Half.Life NA 1.083 hours 1compartment NA NA Human Human +DTXSID3047217 Css NA 0.03032 mg/L 3compartmentss NA 50% Human Human +DTXSID3047217 Css NA 0.3001 mg/L 3compartmentss NA 95% Human Human +DTXSID3047217 Css NA 0.02482 mg/L PBTK NA 50% Human Human +DTXSID3047217 Css NA 0.2106 mg/L PBTK NA 95% Human Human +DTXSID3047217 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047217 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047217 Vd NA 1.003 L/kg 1compartment NA NA Rat Human +DTXSID3047217 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3047217 TK.Half.Life NA 0.4807 hours 1compartment NA NA Rat Human +DTXSID3047217 Css NA 0.001053 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047217 Css NA 0.01258 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047217 Css NA 0.0008489 mg/L PBTK NA 50% Rat Human +DTXSID3047217 Css NA 0.008718 mg/L PBTK NA 95% Rat Human +DTXSID3047261 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047261 Fup 0.0907 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047261 Vd NA 0.4506 L/kg 1compartment NA NA Human Human +DTXSID3047261 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3047261 TK.Half.Life NA 1.232 hours 1compartment NA NA Human Human +DTXSID3047261 Css NA 0.3048 mg/L 3compartmentss NA 50% Human Human +DTXSID3047261 Css NA 2.461 mg/L 3compartmentss NA 95% Human Human +DTXSID3047261 Css NA 0.1986 mg/L PBTK NA 50% Human Human +DTXSID3047261 Css NA 1.515 mg/L PBTK NA 95% Human Human +DTXSID3047261 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047261 Fup 0.0907 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047261 Vd NA 0.4423 L/kg 1compartment NA NA Rat Human +DTXSID3047261 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3047261 TK.Half.Life NA 0.7296 hours 1compartment NA NA Rat Human +DTXSID3047261 Css NA 0.04014 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047261 Css NA 0.2559 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047261 Css NA 0.02551 mg/L PBTK NA 50% Rat Human +DTXSID3047261 Css NA 0.1517 mg/L PBTK NA 95% Rat Human +DTXSID3047263 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047263 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047263 Vd NA 0.9822 L/kg 1compartment NA NA Human Human +DTXSID3047263 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3047263 TK.Half.Life NA 2.6 hours 1compartment NA NA Human Human +DTXSID3047263 Css NA 0.2308 mg/L 3compartmentss NA 50% Human Human +DTXSID3047263 Css NA 1.488 mg/L 3compartmentss NA 95% Human Human +DTXSID3047263 Css NA 0.1691 mg/L PBTK NA 50% Human Human +DTXSID3047263 Css NA 0.9956 mg/L PBTK NA 95% Human Human +DTXSID3047263 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047263 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047263 Vd NA 0.846 L/kg 1compartment NA NA Rat Human DTXSID3047263 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047263 TK.Half.Life NA 8.071 hours 1compartment NA NA Rat Human -DTXSID3047263 Css NA 1.23 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047263 Css NA 3.653 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047263 Css NA 0.796 mg/L PBTK NA 50% Rat Human -DTXSID3047263 Css NA 2.12 mg/L PBTK NA 95% Rat Human -DTXSID3047265 Clint NA 1.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047265 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047265 Vd NA 0.5986 L/kg 1compartment NA NA Human Human -DTXSID3047265 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3047265 TK.Half.Life NA 28.74 hours 1compartment NA NA Human Human -DTXSID3047265 Css NA 8.581 mg/L 3compartmentss NA 50% Human Human -DTXSID3047265 Css NA 47.02 mg/L 3compartmentss NA 95% Human Human -DTXSID3047265 Css NA 5.254 mg/L PBTK NA 50% Human Human -DTXSID3047265 Css NA 27.35 mg/L PBTK NA 95% Human Human -DTXSID3047265 Clint NA 1.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047265 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047265 Vd NA 0.4727 L/kg 1compartment NA NA Rat Human -DTXSID3047265 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3047265 TK.Half.Life NA 12.03 hours 1compartment NA NA Rat Human -DTXSID3047265 Css NA 3.932 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047265 Css NA 17.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047265 Css NA 2.256 mg/L PBTK NA 50% Rat Human -DTXSID3047265 Css NA 9.516 mg/L PBTK NA 95% Rat Human -DTXSID3047267 Clint NA 38.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047267 Fup NA 0.1388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047267 Vd NA 1.46 L/kg 1compartment NA NA Human Human +DTXSID3047263 TK.Half.Life NA 1.231 hours 1compartment NA NA Rat Human +DTXSID3047263 Css NA 0.02745 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047263 Css NA 0.1261 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047263 Css NA 0.01997 mg/L PBTK NA 50% Rat Human +DTXSID3047263 Css NA 0.08161 mg/L PBTK NA 95% Rat Human +DTXSID3047265 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047265 Fup 0.0622 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047265 Vd NA 0.7738 L/kg 1compartment NA NA Human Human +DTXSID3047265 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3047265 TK.Half.Life NA 7.606 hours 1compartment NA NA Human Human +DTXSID3047265 Css NA 0.8162 mg/L 3compartmentss NA 50% Human Human +DTXSID3047265 Css NA 5.963 mg/L 3compartmentss NA 95% Human Human +DTXSID3047265 Css NA 0.517 mg/L PBTK NA 50% Human Human +DTXSID3047265 Css NA 3.568 mg/L PBTK NA 95% Human Human +DTXSID3047265 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047265 Fup 0.0622 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047265 Vd NA 0.611 L/kg 1compartment NA NA Rat Human +DTXSID3047265 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3047265 TK.Half.Life NA 3.542 hours 1compartment NA NA Rat Human +DTXSID3047265 Css NA 0.008362 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047265 Css NA 0.05104 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047265 Css NA 0.004991 mg/L PBTK NA 50% Rat Human +DTXSID3047265 Css NA 0.02916 mg/L PBTK NA 95% Rat Human +DTXSID3047267 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047267 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047267 Vd NA 1.469 L/kg 1compartment NA NA Human Human DTXSID3047267 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047267 TK.Half.Life NA 2.37 hours 1compartment NA NA Human Human -DTXSID3047267 Css NA 0.1217 mg/L 3compartmentss NA 50% Human Human -DTXSID3047267 Css NA 0.9797 mg/L 3compartmentss NA 95% Human Human -DTXSID3047267 Css NA 0.08272 mg/L PBTK NA 50% Human Human -DTXSID3047267 Css NA 0.6208 mg/L PBTK NA 95% Human Human -DTXSID3047267 Clint NA 38.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047267 Fup NA 0.1388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047267 Vd NA 1.141 L/kg 1compartment NA NA Rat Human +DTXSID3047267 TK.Half.Life NA 4.271 hours 1compartment NA NA Human Human +DTXSID3047267 Css NA 0.2566 mg/L 3compartmentss NA 50% Human Human +DTXSID3047267 Css NA 1.557 mg/L 3compartmentss NA 95% Human Human +DTXSID3047267 Css NA 0.1932 mg/L PBTK NA 50% Human Human +DTXSID3047267 Css NA 1.075 mg/L PBTK NA 95% Human Human +DTXSID3047267 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047267 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047267 Vd NA 1.201 L/kg 1compartment NA NA Rat Human DTXSID3047267 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047267 TK.Half.Life NA 0.9176 hours 1compartment NA NA Rat Human -DTXSID3047267 Css NA 0.06876 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047267 Css NA 0.428 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047267 Css NA 0.0444 mg/L PBTK NA 50% Rat Human -DTXSID3047267 Css NA 0.259 mg/L PBTK NA 95% Rat Human -DTXSID3047342 Clint NA 39.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047342 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047342 Vd NA 2.007 L/kg 1compartment NA NA Human Human +DTXSID3047267 TK.Half.Life NA 1.775 hours 1compartment NA NA Rat Human +DTXSID3047267 Css NA 0.03 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047267 Css NA 0.1332 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047267 Css NA 0.02268 mg/L PBTK NA 50% Rat Human +DTXSID3047267 Css NA 0.09021 mg/L PBTK NA 95% Rat Human +DTXSID3047342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047342 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047342 Vd NA 1.55 L/kg 1compartment NA NA Human Human DTXSID3047342 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047342 TK.Half.Life NA 1.645 hours 1compartment NA NA Human Human -DTXSID3047342 Css NA 0.02573 mg/L 3compartmentss NA 50% Human Human -DTXSID3047342 Css NA 0.2415 mg/L 3compartmentss NA 95% Human Human -DTXSID3047342 Css NA 0.02108 mg/L PBTK NA 50% Human Human -DTXSID3047342 Css NA 0.1709 mg/L PBTK NA 95% Human Human -DTXSID3047342 Clint NA 39.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047342 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047342 Vd NA 1.884 L/kg 1compartment NA NA Rat Human +DTXSID3047342 TK.Half.Life NA 2.193 hours 1compartment NA NA Human Human +DTXSID3047342 Css NA 0.1051 mg/L 3compartmentss NA 50% Human Human +DTXSID3047342 Css NA 1.257 mg/L 3compartmentss NA 95% Human Human +DTXSID3047342 Css NA 0.08011 mg/L PBTK NA 50% Human Human +DTXSID3047342 Css NA 0.8316 mg/L PBTK NA 95% Human Human +DTXSID3047342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047342 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047342 Vd NA 1.486 L/kg 1compartment NA NA Rat Human DTXSID3047342 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047342 TK.Half.Life NA 0.7492 hours 1compartment NA NA Rat Human -DTXSID3047342 Css NA 0.01487 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047342 Css NA 0.1169 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047342 Css NA 0.0115 mg/L PBTK NA 50% Rat Human -DTXSID3047342 Css NA 0.07817 mg/L PBTK NA 95% Rat Human +DTXSID3047342 TK.Half.Life NA 1.182 hours 1compartment NA NA Rat Human +DTXSID3047342 Css NA 0.014 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047342 Css NA 0.1339 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047342 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID3047342 Css NA 0.086 mg/L PBTK NA 95% Rat Human DTXSID3047344 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3047344 Fup 0.451 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3047344 Vd NA 0.4932 L/kg 1compartment NA NA Human Human -DTXSID3047344 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047344 TK.Half.Life NA 7.106 hours 1compartment NA NA Human Human -DTXSID3047344 Css NA 1.552 mg/L 3compartmentss NA 50% Human Human -DTXSID3047344 Css NA 4.526 mg/L 3compartmentss NA 95% Human Human -DTXSID3047344 Css NA 1.128 mg/L PBTK NA 50% Human Human -DTXSID3047344 Css NA 2.976 mg/L PBTK NA 95% Human Human +DTXSID3047344 Vd NA 1.286 L/kg 1compartment NA NA Human Human +DTXSID3047344 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3047344 TK.Half.Life NA 21.9 hours 1compartment NA NA Human Human +DTXSID3047344 Css NA 1.562 mg/L 3compartmentss NA 50% Human Human +DTXSID3047344 Css NA 4.698 mg/L 3compartmentss NA 95% Human Human +DTXSID3047344 Css NA 1.278 mg/L PBTK NA 50% Human Human +DTXSID3047344 Css NA 3.365 mg/L PBTK NA 95% Human Human DTXSID3047344 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3047344 Fup 0.451 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3047344 Vd NA 0.4855 L/kg 1compartment NA NA Rat Human +DTXSID3047344 Vd NA 1.069 L/kg 1compartment NA NA Rat Human DTXSID3047344 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047344 TK.Half.Life NA 2.376 hours 1compartment NA NA Rat Human -DTXSID3047344 Css NA 0.4199 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047344 Css NA 0.9932 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047344 Css NA 0.2934 mg/L PBTK NA 50% Rat Human -DTXSID3047344 Css NA 0.6119 mg/L PBTK NA 95% Rat Human -DTXSID3047346 Clint NA 46.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3047344 TK.Half.Life NA 5.462 hours 1compartment NA NA Rat Human +DTXSID3047344 Css NA 0.08982 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047344 Css NA 0.226 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047344 Css NA 0.07462 mg/L PBTK NA 50% Rat Human +DTXSID3047344 Css NA 0.1567 mg/L PBTK NA 95% Rat Human +DTXSID3047346 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3047346 Fup 0.702 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3047346 Vd NA 1.211 L/kg 1compartment NA NA Human Human +DTXSID3047346 Vd NA 1.218 L/kg 1compartment NA NA Human Human DTXSID3047346 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047346 TK.Half.Life NA 0.8336 hours 1compartment NA NA Human Human -DTXSID3047346 Css NA 0.01242 mg/L 3compartmentss NA 50% Human Human -DTXSID3047346 Css NA 0.08259 mg/L 3compartmentss NA 95% Human Human -DTXSID3047346 Css NA 0.01094 mg/L PBTK NA 50% Human Human -DTXSID3047346 Css NA 0.06648 mg/L PBTK NA 95% Human Human -DTXSID3047346 Clint NA 46.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3047346 TK.Half.Life NA 1.634 hours 1compartment NA NA Human Human +DTXSID3047346 Css NA 0.07886 mg/L 3compartmentss NA 50% Human Human +DTXSID3047346 Css NA 0.4333 mg/L 3compartmentss NA 95% Human Human +DTXSID3047346 Css NA 0.06959 mg/L PBTK NA 50% Human Human +DTXSID3047346 Css NA 0.3522 mg/L PBTK NA 95% Human Human +DTXSID3047346 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3047346 Fup 0.702 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3047346 Vd NA 1.111 L/kg 1compartment NA NA Rat Human +DTXSID3047346 Vd NA 1.116 L/kg 1compartment NA NA Rat Human DTXSID3047346 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047346 TK.Half.Life NA 0.3531 hours 1compartment NA NA Rat Human -DTXSID3047346 Css NA 0.006423 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047346 Css NA 0.03493 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047346 Css NA 0.005593 mg/L PBTK NA 50% Rat Human -DTXSID3047346 Css NA 0.0281 mg/L PBTK NA 95% Rat Human -DTXSID3047348 Clint NA 67.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047348 Fup NA 0.0419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047348 Vd NA 1.792 L/kg 1compartment NA NA Human Human +DTXSID3047346 TK.Half.Life NA 0.7781 hours 1compartment NA NA Rat Human +DTXSID3047346 Css NA 0.008147 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047346 Css NA 0.03405 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047346 Css NA 0.007503 mg/L PBTK NA 50% Rat Human +DTXSID3047346 Css NA 0.02685 mg/L PBTK NA 95% Rat Human +DTXSID3047348 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047348 Fup 0.0542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047348 Vd NA 2.039 L/kg 1compartment NA NA Human Human DTXSID3047348 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047348 TK.Half.Life NA 3.398 hours 1compartment NA NA Human Human -DTXSID3047348 Css NA 0.174 mg/L 3compartmentss NA 50% Human Human -DTXSID3047348 Css NA 1.432 mg/L 3compartmentss NA 95% Human Human -DTXSID3047348 Css NA 0.1193 mg/L PBTK NA 50% Human Human -DTXSID3047348 Css NA 0.9093 mg/L PBTK NA 95% Human Human -DTXSID3047348 Clint NA 67.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047348 Fup NA 0.0419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047348 Vd NA 1.531 L/kg 1compartment NA NA Rat Human +DTXSID3047348 TK.Half.Life NA 7.208 hours 1compartment NA NA Human Human +DTXSID3047348 Css NA 0.4103 mg/L 3compartmentss NA 50% Human Human +DTXSID3047348 Css NA 3.335 mg/L 3compartmentss NA 95% Human Human +DTXSID3047348 Css NA 0.2924 mg/L PBTK NA 50% Human Human +DTXSID3047348 Css NA 2.201 mg/L PBTK NA 95% Human Human +DTXSID3047348 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047348 Fup 0.0542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047348 Vd NA 1.749 L/kg 1compartment NA NA Rat Human DTXSID3047348 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047348 TK.Half.Life NA 1.512 hours 1compartment NA NA Rat Human -DTXSID3047348 Css NA 0.09932 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047348 Css NA 0.6398 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047348 Css NA 0.06408 mg/L PBTK NA 50% Rat Human -DTXSID3047348 Css NA 0.3928 mg/L PBTK NA 95% Rat Human -DTXSID3047394 Clint NA 562.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047394 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047394 Vd NA 9.091 L/kg 1compartment NA NA Human Human -DTXSID3047394 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047394 TK.Half.Life NA 14.81 hours 1compartment NA NA Human Human -DTXSID3047394 Css NA 0.08366 mg/L 3compartmentss NA 50% Human Human -DTXSID3047394 Css NA 0.5036 mg/L 3compartmentss NA 95% Human Human -DTXSID3047394 Css NA 0.09381 mg/L PBTK NA 50% Human Human -DTXSID3047394 Css NA 0.5473 mg/L PBTK NA 95% Human Human -DTXSID3047394 Clint NA 562.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047394 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047394 Vd NA 7.126 L/kg 1compartment NA NA Rat Human -DTXSID3047394 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047394 TK.Half.Life NA 2.933 hours 1compartment NA NA Rat Human -DTXSID3047394 Css NA 0.04592 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047394 Css NA 0.1993 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047394 Css NA 0.05074 mg/L PBTK NA 50% Rat Human -DTXSID3047394 Css NA 0.2165 mg/L PBTK NA 95% Rat Human -DTXSID3047423 Clint NA 4.494 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047423 Fup NA 0.1835 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047423 Vd NA 0.7593 L/kg 1compartment NA NA Human Human +DTXSID3047348 TK.Half.Life NA 3.25 hours 1compartment NA NA Rat Human +DTXSID3047348 Css NA 0.05213 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047348 Css NA 0.3464 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047348 Css NA 0.03642 mg/L PBTK NA 50% Rat Human +DTXSID3047348 Css NA 0.2202 mg/L PBTK NA 95% Rat Human +DTXSID3047423 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047423 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047423 Vd NA 0.7378 L/kg 1compartment NA NA Human Human DTXSID3047423 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047423 TK.Half.Life NA 3.705 hours 1compartment NA NA Human Human -DTXSID3047423 Css NA 0.5386 mg/L 3compartmentss NA 50% Human Human -DTXSID3047423 Css NA 2.96 mg/L 3compartmentss NA 95% Human Human -DTXSID3047423 Css NA 0.3677 mg/L PBTK NA 50% Human Human -DTXSID3047423 Css NA 1.904 mg/L PBTK NA 95% Human Human -DTXSID3047423 Clint NA 4.494 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047423 Fup NA 0.1835 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047423 Vd NA 0.6502 L/kg 1compartment NA NA Rat Human +DTXSID3047423 TK.Half.Life NA 1.209 hours 1compartment NA NA Human Human +DTXSID3047423 Css NA 0.1061 mg/L 3compartmentss NA 50% Human Human +DTXSID3047423 Css NA 0.752 mg/L 3compartmentss NA 95% Human Human +DTXSID3047423 Css NA 0.07306 mg/L PBTK NA 50% Human Human +DTXSID3047423 Css NA 0.4828 mg/L PBTK NA 95% Human Human +DTXSID3047423 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047423 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047423 Vd NA 0.6415 L/kg 1compartment NA NA Rat Human DTXSID3047423 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047423 TK.Half.Life NA 1.804 hours 1compartment NA NA Rat Human -DTXSID3047423 Css NA 0.2718 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047423 Css NA 1.078 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047423 Css NA 0.1768 mg/L PBTK NA 50% Rat Human -DTXSID3047423 Css NA 0.6449 mg/L PBTK NA 95% Rat Human +DTXSID3047423 TK.Half.Life NA 0.5733 hours 1compartment NA NA Rat Human +DTXSID3047423 Css NA 0.01342 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047423 Css NA 0.07313 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047423 Css NA 0.0091 mg/L PBTK NA 50% Rat Human +DTXSID3047423 Css NA 0.0463 mg/L PBTK NA 95% Rat Human DTXSID3047425 Clint 127 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3047425 Fup 0.0358 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3047425 Vd NA 2.135 L/kg 1compartment NA NA Human Human DTXSID3047425 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3047425 TK.Half.Life NA 4.191 hours 1compartment NA NA Human Human -DTXSID3047425 Css NA 0.1367 mg/L 3compartmentss NA 50% Human Human -DTXSID3047425 Css NA 0.9838 mg/L 3compartmentss NA 95% Human Human -DTXSID3047425 Css NA 0.09158 mg/L PBTK NA 50% Human Human -DTXSID3047425 Css NA 0.6445 mg/L PBTK NA 95% Human Human +DTXSID3047425 Css NA 0.1324 mg/L 3compartmentss NA 50% Human Human +DTXSID3047425 Css NA 0.9833 mg/L 3compartmentss NA 95% Human Human +DTXSID3047425 Css NA 0.08832 mg/L PBTK NA 50% Human Human +DTXSID3047425 Css NA 0.6429 mg/L PBTK NA 95% Human Human DTXSID3047425 Clint 127 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3047425 Fup 0.0358 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3047425 Vd NA 1.594 L/kg 1compartment NA NA Rat Human DTXSID3047425 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3047425 TK.Half.Life NA 1.323 hours 1compartment NA NA Rat Human -DTXSID3047425 Css NA 0.07742 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047425 Css NA 0.451 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047425 Css NA 0.04916 mg/L PBTK NA 50% Rat Human -DTXSID3047425 Css NA 0.2789 mg/L PBTK NA 95% Rat Human -DTXSID3047427 Clint NA 9.361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047427 Fup NA 0.0105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047427 Vd NA 19.78 L/kg 1compartment NA NA Human Human -DTXSID3047427 Days.Css NA 340 Days PBTK NA NA Human Human -DTXSID3047427 TK.Half.Life NA 1359 hours 1compartment NA NA Human Human -DTXSID3047427 Css NA 2.711 mg/L 3compartmentss NA 50% Human Human -DTXSID3047427 Css NA 15.63 mg/L 3compartmentss NA 95% Human Human -DTXSID3047427 Css NA 5.696 mg/L PBTK NA 50% Human Human -DTXSID3047427 Css NA 30.92 mg/L PBTK NA 95% Human Human -DTXSID3047427 Clint NA 9.361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047427 Fup NA 0.0105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047427 Vd NA 16.05 L/kg 1compartment NA NA Rat Human -DTXSID3047427 Days.Css NA 202 Days PBTK NA NA Rat Human -DTXSID3047427 TK.Half.Life NA 192.9 hours 1compartment NA NA Rat Human -DTXSID3047427 Css NA 1.42 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047427 Css NA 6.158 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047427 Css NA 3.054 mg/L PBTK NA 50% Rat Human -DTXSID3047427 Css NA 12.92 mg/L PBTK NA 95% Rat Human +DTXSID3047425 Css NA 0.0173 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047425 Css NA 0.1127 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047425 Css NA 0.01141 mg/L PBTK NA 50% Rat Human +DTXSID3047425 Css NA 0.07188 mg/L PBTK NA 95% Rat Human DTXSID3047429 Clint 9.63 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3047429 Fup 0.0956 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3047429 Vd NA 0.2885 L/kg 1compartment NA NA Human Human +DTXSID3047429 Vd NA 0.284 L/kg 1compartment NA NA Human Human DTXSID3047429 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047429 TK.Half.Life NA 1.383 hours 1compartment NA NA Human Human -DTXSID3047429 Css NA 0.5228 mg/L 3compartmentss NA 50% Human Human -DTXSID3047429 Css NA 3.037 mg/L 3compartmentss NA 95% Human Human -DTXSID3047429 Css NA 0.3214 mg/L PBTK NA 50% Human Human -DTXSID3047429 Css NA 1.838 mg/L PBTK NA 95% Human Human +DTXSID3047429 TK.Half.Life NA 1.362 hours 1compartment NA NA Human Human +DTXSID3047429 Css NA 0.2722 mg/L 3compartmentss NA 50% Human Human +DTXSID3047429 Css NA 1.834 mg/L 3compartmentss NA 95% Human Human +DTXSID3047429 Css NA 0.1668 mg/L PBTK NA 50% Human Human +DTXSID3047429 Css NA 1.101 mg/L PBTK NA 95% Human Human DTXSID3047429 Clint 9.63 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3047429 Fup 0.0956 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3047429 Vd NA 0.2746 L/kg 1compartment NA NA Rat Human +DTXSID3047429 Vd NA 0.2713 L/kg 1compartment NA NA Rat Human DTXSID3047429 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047429 TK.Half.Life NA 0.8076 hours 1compartment NA NA Rat Human -DTXSID3047429 Css NA 0.2853 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047429 Css NA 1.211 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047429 Css NA 0.1652 mg/L PBTK NA 50% Rat Human -DTXSID3047429 Css NA 0.6821 mg/L PBTK NA 95% Rat Human +DTXSID3047429 TK.Half.Life NA 0.7986 hours 1compartment NA NA Rat Human +DTXSID3047429 Css NA 0.002804 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047429 Css NA 0.01514 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047429 Css NA 0.001626 mg/L PBTK NA 50% Rat Human +DTXSID3047429 Css NA 0.008567 mg/L PBTK NA 95% Rat Human DTXSID3047471 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3047471 Fup NA 0.8801 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047471 Vd NA 1.159 L/kg 1compartment NA NA Human Human +DTXSID3047471 Vd NA 1.086 L/kg 1compartment NA NA Human Human DTXSID3047471 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047471 TK.Half.Life NA 8.873 hours 1compartment NA NA Human Human -DTXSID3047471 Css NA 0.873 mg/L 3compartmentss NA 50% Human Human -DTXSID3047471 Css NA 5.124 mg/L 3compartmentss NA 95% Human Human -DTXSID3047471 Css NA 0.7844 mg/L PBTK NA 50% Human Human -DTXSID3047471 Css NA 3.473 mg/L PBTK NA 95% Human Human +DTXSID3047471 TK.Half.Life NA 8.218 hours 1compartment NA NA Human Human +DTXSID3047471 Css NA 0.746 mg/L 3compartmentss NA 50% Human Human +DTXSID3047471 Css NA 4.37 mg/L 3compartmentss NA 95% Human Human +DTXSID3047471 Css NA 0.6648 mg/L PBTK NA 50% Human Human +DTXSID3047471 Css NA 2.989 mg/L PBTK NA 95% Human Human DTXSID3047471 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3047471 Fup NA 0.8801 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047471 Vd NA 1.108 L/kg 1compartment NA NA Rat Human +DTXSID3047471 Vd NA 1.053 L/kg 1compartment NA NA Rat Human DTXSID3047471 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047471 TK.Half.Life NA 2.803 hours 1compartment NA NA Rat Human -DTXSID3047471 Css NA 0.2224 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047471 Css NA 1.385 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047471 Css NA 0.1956 mg/L PBTK NA 50% Rat Human -DTXSID3047471 Css NA 0.8558 mg/L PBTK NA 95% Rat Human -DTXSID3047473 Clint NA 6.982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047473 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047473 Vd NA 1.614 L/kg 1compartment NA NA Human Human -DTXSID3047473 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3047473 TK.Half.Life NA 19.52 hours 1compartment NA NA Human Human -DTXSID3047473 Css NA 1.84 mg/L 3compartmentss NA 50% Human Human -DTXSID3047473 Css NA 12.59 mg/L 3compartmentss NA 95% Human Human -DTXSID3047473 Css NA 1.19 mg/L PBTK NA 50% Human Human -DTXSID3047473 Css NA 7.664 mg/L PBTK NA 95% Human Human -DTXSID3047473 Clint NA 6.982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047473 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047473 Vd NA 1.213 L/kg 1compartment NA NA Rat Human -DTXSID3047473 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047473 TK.Half.Life NA 7.131 hours 1compartment NA NA Rat Human -DTXSID3047473 Css NA 0.9898 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047473 Css NA 4.852 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047473 Css NA 0.6018 mg/L PBTK NA 50% Rat Human -DTXSID3047473 Css NA 2.776 mg/L PBTK NA 95% Rat Human +DTXSID3047471 TK.Half.Life NA 2.657 hours 1compartment NA NA Rat Human +DTXSID3047471 Css NA 0.01398 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047471 Css NA 0.1004 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047471 Css NA 0.01211 mg/L PBTK NA 50% Rat Human +DTXSID3047471 Css NA 0.06842 mg/L PBTK NA 95% Rat Human DTXSID3047477 Clint 11 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3047477 Fup 0.0392 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3047477 Vd NA 1.364 L/kg 1compartment NA NA Human Human +DTXSID3047477 Vd NA 1.298 L/kg 1compartment NA NA Human Human DTXSID3047477 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3047477 TK.Half.Life NA 13.32 hours 1compartment NA NA Human Human -DTXSID3047477 Css NA 1.103 mg/L 3compartmentss NA 50% Human Human -DTXSID3047477 Css NA 6.642 mg/L 3compartmentss NA 95% Human Human -DTXSID3047477 Css NA 0.7151 mg/L PBTK NA 50% Human Human -DTXSID3047477 Css NA 4.141 mg/L PBTK NA 95% Human Human +DTXSID3047477 TK.Half.Life NA 12.52 hours 1compartment NA NA Human Human +DTXSID3047477 Css NA 1.073 mg/L 3compartmentss NA 50% Human Human +DTXSID3047477 Css NA 6.77 mg/L 3compartmentss NA 95% Human Human +DTXSID3047477 Css NA 0.6882 mg/L PBTK NA 50% Human Human +DTXSID3047477 Css NA 4.182 mg/L PBTK NA 95% Human Human DTXSID3047477 Clint 11 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3047477 Fup 0.0392 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3047477 Vd NA 1.022 L/kg 1compartment NA NA Rat Human +DTXSID3047477 Vd NA 0.9743 L/kg 1compartment NA NA Rat Human DTXSID3047477 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047477 TK.Half.Life NA 5.316 hours 1compartment NA NA Rat Human -DTXSID3047477 Css NA 0.6085 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047477 Css NA 2.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047477 Css NA 0.3692 mg/L PBTK NA 50% Rat Human -DTXSID3047477 Css NA 1.668 mg/L PBTK NA 95% Rat Human -DTXSID3047504 Clint NA 123.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047504 Fup NA 0.5457 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047504 Vd NA 3.277 L/kg 1compartment NA NA Human Human +DTXSID3047477 TK.Half.Life NA 5.093 hours 1compartment NA NA Rat Human +DTXSID3047477 Css NA 0.1366 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047477 Css NA 0.6347 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047477 Css NA 0.08591 mg/L PBTK NA 50% Rat Human +DTXSID3047477 Css NA 0.3832 mg/L PBTK NA 95% Rat Human +DTXSID3047504 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047504 Fup 0.594 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047504 Vd NA 1.126 L/kg 1compartment NA NA Human Human DTXSID3047504 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047504 TK.Half.Life NA 1.52 hours 1compartment NA NA Human Human -DTXSID3047504 Css NA 0.00432 mg/L 3compartmentss NA 50% Human Human -DTXSID3047504 Css NA 0.05456 mg/L 3compartmentss NA 95% Human Human -DTXSID3047504 Css NA 0.005322 mg/L PBTK NA 50% Human Human -DTXSID3047504 Css NA 0.04832 mg/L PBTK NA 95% Human Human -DTXSID3047504 Clint NA 123.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047504 Fup NA 0.5457 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047504 Vd NA 3.309 L/kg 1compartment NA NA Rat Human +DTXSID3047504 TK.Half.Life NA 1.633 hours 1compartment NA NA Human Human +DTXSID3047504 Css NA 0.08834 mg/L 3compartmentss NA 50% Human Human +DTXSID3047504 Css NA 0.8531 mg/L 3compartmentss NA 95% Human Human +DTXSID3047504 Css NA 0.07683 mg/L PBTK NA 50% Human Human +DTXSID3047504 Css NA 0.5924 mg/L PBTK NA 95% Human Human +DTXSID3047504 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047504 Fup 0.594 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047504 Vd NA 1.148 L/kg 1compartment NA NA Rat Human DTXSID3047504 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047504 TK.Half.Life NA 0.7088 hours 1compartment NA NA Rat Human -DTXSID3047504 Css NA 0.002252 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047504 Css NA 0.02465 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047504 Css NA 0.002794 mg/L PBTK NA 50% Rat Human -DTXSID3047504 Css NA 0.0202 mg/L PBTK NA 95% Rat Human -DTXSID3047508 Clint NA 42.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047508 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047508 Vd NA 1.221 L/kg 1compartment NA NA Human Human -DTXSID3047508 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047508 TK.Half.Life NA 6.394 hours 1compartment NA NA Human Human -DTXSID3047508 Css NA 0.7872 mg/L 3compartmentss NA 50% Human Human -DTXSID3047508 Css NA 7.507 mg/L 3compartmentss NA 95% Human Human -DTXSID3047508 Css NA 0.4842 mg/L PBTK NA 50% Human Human -DTXSID3047508 Css NA 4.405 mg/L PBTK NA 95% Human Human -DTXSID3047508 Clint NA 42.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047508 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047508 Vd NA 0.9064 L/kg 1compartment NA NA Rat Human -DTXSID3047508 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047508 TK.Half.Life NA 2.631 hours 1compartment NA NA Rat Human -DTXSID3047508 Css NA 0.4442 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047508 Css NA 3.424 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047508 Css NA 0.2569 mg/L PBTK NA 50% Rat Human -DTXSID3047508 Css NA 1.934 mg/L PBTK NA 95% Rat Human -DTXSID3047554 Clint NA 17.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047554 Fup NA 0.0499 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047554 Vd NA 1.926 L/kg 1compartment NA NA Human Human -DTXSID3047554 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047554 TK.Half.Life NA 12.41 hours 1compartment NA NA Human Human -DTXSID3047554 Css NA 0.9044 mg/L 3compartmentss NA 50% Human Human -DTXSID3047554 Css NA 6.278 mg/L 3compartmentss NA 95% Human Human -DTXSID3047554 Css NA 0.59 mg/L PBTK NA 50% Human Human -DTXSID3047554 Css NA 3.919 mg/L PBTK NA 95% Human Human -DTXSID3047554 Clint NA 17.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047554 Fup NA 0.0499 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047554 Vd NA 1.443 L/kg 1compartment NA NA Rat Human +DTXSID3047504 TK.Half.Life NA 0.911 hours 1compartment NA NA Rat Human +DTXSID3047504 Css NA 0.00394 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047504 Css NA 0.04354 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047504 Css NA 0.003464 mg/L PBTK NA 50% Rat Human +DTXSID3047504 Css NA 0.02886 mg/L PBTK NA 95% Rat Human +DTXSID3047508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047508 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047508 Vd NA 1.467 L/kg 1compartment NA NA Human Human +DTXSID3047508 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3047508 TK.Half.Life NA 19.48 hours 1compartment NA NA Human Human +DTXSID3047508 Css NA 2.144 mg/L 3compartmentss NA 50% Human Human +DTXSID3047508 Css NA 20.04 mg/L 3compartmentss NA 95% Human Human +DTXSID3047508 Css NA 1.324 mg/L PBTK NA 50% Human Human +DTXSID3047508 Css NA 11.85 mg/L PBTK NA 95% Human Human +DTXSID3047508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047508 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047508 Vd NA 1.083 L/kg 1compartment NA NA Rat Human +DTXSID3047508 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3047508 TK.Half.Life NA 7.575 hours 1compartment NA NA Rat Human +DTXSID3047508 Css NA 0.2794 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047508 Css NA 2.057 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047508 Css NA 0.1683 mg/L PBTK NA 50% Rat Human +DTXSID3047508 Css NA 1.193 mg/L PBTK NA 95% Rat Human +DTXSID3047554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047554 Fup 0.0254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047554 Vd NA 1.793 L/kg 1compartment NA NA Human Human +DTXSID3047554 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3047554 TK.Half.Life NA 14.74 hours 1compartment NA NA Human Human +DTXSID3047554 Css NA 1.217 mg/L 3compartmentss NA 50% Human Human +DTXSID3047554 Css NA 10.32 mg/L 3compartmentss NA 95% Human Human +DTXSID3047554 Css NA 0.7775 mg/L PBTK NA 50% Human Human +DTXSID3047554 Css NA 6.446 mg/L PBTK NA 95% Human Human +DTXSID3047554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047554 Fup 0.0254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047554 Vd NA 1.335 L/kg 1compartment NA NA Rat Human DTXSID3047554 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047554 TK.Half.Life NA 4.146 hours 1compartment NA NA Rat Human -DTXSID3047554 Css NA 0.4945 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047554 Css NA 2.818 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047554 Css NA 0.3053 mg/L PBTK NA 50% Rat Human -DTXSID3047554 Css NA 1.668 mg/L PBTK NA 95% Rat Human -DTXSID3047556 Clint NA 41.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047556 Fup NA 0.0316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047556 Vd NA 3.099 L/kg 1compartment NA NA Human Human -DTXSID3047556 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3047556 TK.Half.Life NA 40.85 hours 1compartment NA NA Human Human -DTXSID3047556 Css NA 1.564 mg/L 3compartmentss NA 50% Human Human -DTXSID3047556 Css NA 10.45 mg/L 3compartmentss NA 95% Human Human -DTXSID3047556 Css NA 1.082 mg/L PBTK NA 50% Human Human -DTXSID3047556 Css NA 6.964 mg/L PBTK NA 95% Human Human -DTXSID3047556 Clint NA 41.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047556 Fup NA 0.0316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047556 Vd NA 2.322 L/kg 1compartment NA NA Rat Human -DTXSID3047556 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3047556 TK.Half.Life NA 5.934 hours 1compartment NA NA Rat Human -DTXSID3047556 Css NA 0.8745 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047556 Css NA 4.718 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047556 Css NA 0.5788 mg/L PBTK NA 50% Rat Human -DTXSID3047556 Css NA 3.072 mg/L PBTK NA 95% Rat Human -DTXSID3047558 Clint 196.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3047558 Fup 0.02654 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID3047558 Vd NA 2.697 L/kg 1compartment NA NA Human Human -DTXSID3047558 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047558 TK.Half.Life NA 5.196 hours 1compartment NA NA Human Human -DTXSID3047558 Css NA 0.1854 mg/L 3compartmentss NA 50% Human Human -DTXSID3047558 Css NA 1.323 mg/L 3compartmentss NA 95% Human Human -DTXSID3047558 Css NA 0.1244 mg/L PBTK NA 50% Human Human -DTXSID3047558 Css NA 0.8616 mg/L PBTK NA 95% Human Human -DTXSID3047558 Clint 196.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3047558 Fup 0.02654 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID3047558 Vd NA 2.017 L/kg 1compartment NA NA Rat Human -DTXSID3047558 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047558 TK.Half.Life NA 1.299 hours 1compartment NA NA Rat Human -DTXSID3047558 Css NA 0.105 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047558 Css NA 0.6105 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047558 Css NA 0.06695 mg/L PBTK NA 50% Rat Human -DTXSID3047558 Css NA 0.3748 mg/L PBTK NA 95% Rat Human -DTXSID3047631 Clint NA 0.06885 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047631 Fup NA 0.8007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047631 Vd NA 1.47 L/kg 1compartment NA NA Human Human -DTXSID3047631 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3047631 TK.Half.Life NA 12.06 hours 1compartment NA NA Human Human -DTXSID3047631 Css NA 0.834 mg/L 3compartmentss NA 50% Human Human -DTXSID3047631 Css NA 5.266 mg/L 3compartmentss NA 95% Human Human -DTXSID3047631 Css NA 0.7698 mg/L PBTK NA 50% Human Human -DTXSID3047631 Css NA 3.502 mg/L PBTK NA 95% Human Human -DTXSID3047631 Clint NA 0.06885 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047631 Fup NA 0.8007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047631 Vd NA 1.317 L/kg 1compartment NA NA Rat Human +DTXSID3047554 TK.Half.Life NA 5.154 hours 1compartment NA NA Rat Human +DTXSID3047554 Css NA 0.1568 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047554 Css NA 1.044 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047554 Css NA 0.09752 mg/L PBTK NA 50% Rat Human +DTXSID3047554 Css NA 0.6199 mg/L PBTK NA 95% Rat Human +DTXSID3047631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047631 Fup 0.556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047631 Vd NA 1.121 L/kg 1compartment NA NA Human Human +DTXSID3047631 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3047631 TK.Half.Life NA 1.038 hours 1compartment NA NA Human Human +DTXSID3047631 Css NA 0.02842 mg/L 3compartmentss NA 50% Human Human +DTXSID3047631 Css NA 0.3285 mg/L 3compartmentss NA 95% Human Human +DTXSID3047631 Css NA 0.02342 mg/L PBTK NA 50% Human Human +DTXSID3047631 Css NA 0.233 mg/L PBTK NA 95% Human Human +DTXSID3047631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047631 Fup 0.556 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047631 Vd NA 1.013 L/kg 1compartment NA NA Rat Human DTXSID3047631 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047631 TK.Half.Life NA 3.542 hours 1compartment NA NA Rat Human -DTXSID3047631 Css NA 0.228 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047631 Css NA 1.427 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047631 Css NA 0.2056 mg/L PBTK NA 50% Rat Human -DTXSID3047631 Css NA 0.8896 mg/L PBTK NA 95% Rat Human -DTXSID3047633 Clint NA 10.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047633 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047633 Vd NA 89.86 L/kg 1compartment NA NA Human Human -DTXSID3047633 Days.Css NA 1447 Days PBTK NA NA Human Human -DTXSID3047633 TK.Half.Life NA 5352 hours 1compartment NA NA Human Human -DTXSID3047633 Css NA 0.4642 mg/L 3compartmentss NA 50% Human Human -DTXSID3047633 Css NA 2.813 mg/L 3compartmentss NA 95% Human Human -DTXSID3047633 Css NA 4.96 mg/L PBTK NA 50% Human Human -DTXSID3047633 Css NA 26.9 mg/L PBTK NA 95% Human Human -DTXSID3047633 Clint NA 10.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047633 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047633 Vd NA 77.39 L/kg 1compartment NA NA Rat Human -DTXSID3047633 Days.Css NA 885 Days PBTK NA NA Rat Human -DTXSID3047633 TK.Half.Life NA 809.9 hours 1compartment NA NA Rat Human -DTXSID3047633 Css NA 0.2357 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047633 Css NA 1.015 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047633 Css NA 2.676 mg/L PBTK NA 50% Rat Human -DTXSID3047633 Css NA 12.03 mg/L PBTK NA 95% Rat Human -DTXSID3047681 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047681 Fup NA 0.9639 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047681 Vd NA 1.199 L/kg 1compartment NA NA Human Human +DTXSID3047631 TK.Half.Life NA 0.4627 hours 1compartment NA NA Rat Human +DTXSID3047631 Css NA 0.001002 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047631 Css NA 0.01293 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047631 Css NA 0.000828 mg/L PBTK NA 50% Rat Human +DTXSID3047631 Css NA 0.008839 mg/L PBTK NA 95% Rat Human +DTXSID3047681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047681 Fup 0.772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047681 Vd NA 1.117 L/kg 1compartment NA NA Human Human DTXSID3047681 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047681 TK.Half.Life NA 8.373 hours 1compartment NA NA Human Human -DTXSID3047681 Css NA 0.8194 mg/L 3compartmentss NA 50% Human Human -DTXSID3047681 Css NA 4.764 mg/L 3compartmentss NA 95% Human Human -DTXSID3047681 Css NA 0.7472 mg/L PBTK NA 50% Human Human -DTXSID3047681 Css NA 3.291 mg/L PBTK NA 95% Human Human -DTXSID3047681 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047681 Fup NA 0.9639 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047681 Vd NA 1.152 L/kg 1compartment NA NA Rat Human +DTXSID3047681 TK.Half.Life NA 0.8604 hours 1compartment NA NA Human Human +DTXSID3047681 Css NA 0.02545 mg/L 3compartmentss NA 50% Human Human +DTXSID3047681 Css NA 0.2915 mg/L 3compartmentss NA 95% Human Human +DTXSID3047681 Css NA 0.02193 mg/L PBTK NA 50% Human Human +DTXSID3047681 Css NA 0.2114 mg/L PBTK NA 95% Human Human +DTXSID3047681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047681 Fup 0.772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047681 Vd NA 1.057 L/kg 1compartment NA NA Rat Human DTXSID3047681 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047681 TK.Half.Life NA 2.661 hours 1compartment NA NA Rat Human -DTXSID3047681 Css NA 0.209 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047681 Css NA 1.179 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047681 Css NA 0.1864 mg/L PBTK NA 50% Rat Human -DTXSID3047681 Css NA 0.7408 mg/L PBTK NA 95% Rat Human -DTXSID3047683 Clint NA 1.425 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047683 Fup NA 0.7117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047683 Vd NA 1.419 L/kg 1compartment NA NA Human Human -DTXSID3047683 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047683 TK.Half.Life NA 4.665 hours 1compartment NA NA Human Human -DTXSID3047683 Css NA 0.3148 mg/L 3compartmentss NA 50% Human Human -DTXSID3047683 Css NA 2.267 mg/L 3compartmentss NA 95% Human Human -DTXSID3047683 Css NA 0.2822 mg/L PBTK NA 50% Human Human -DTXSID3047683 Css NA 1.543 mg/L PBTK NA 95% Human Human -DTXSID3047683 Clint NA 1.425 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047683 Fup NA 0.7117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047683 Vd NA 1.261 L/kg 1compartment NA NA Rat Human +DTXSID3047681 TK.Half.Life NA 0.3943 hours 1compartment NA NA Rat Human +DTXSID3047681 Css NA 0.003031 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047681 Css NA 0.02849 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047681 Css NA 0.002704 mg/L PBTK NA 50% Rat Human +DTXSID3047681 Css NA 0.01979 mg/L PBTK NA 95% Rat Human +DTXSID3047683 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047683 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047683 Vd NA 0.7648 L/kg 1compartment NA NA Human Human +DTXSID3047683 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3047683 TK.Half.Life NA 11.16 hours 1compartment NA NA Human Human +DTXSID3047683 Css NA 1.534 mg/L 3compartmentss NA 50% Human Human +DTXSID3047683 Css NA 7.145 mg/L 3compartmentss NA 95% Human Human +DTXSID3047683 Css NA 1.191 mg/L PBTK NA 50% Human Human +DTXSID3047683 Css NA 4.63 mg/L PBTK NA 95% Human Human +DTXSID3047683 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047683 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047683 Vd NA 0.7298 L/kg 1compartment NA NA Rat Human DTXSID3047683 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047683 TK.Half.Life NA 1.94 hours 1compartment NA NA Rat Human -DTXSID3047683 Css NA 0.1278 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047683 Css NA 0.8651 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047683 Css NA 0.1124 mg/L PBTK NA 50% Rat Human -DTXSID3047683 Css NA 0.5402 mg/L PBTK NA 95% Rat Human -DTXSID3047687 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047687 Fup NA 0.781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047687 Vd NA 0.412 L/kg 1compartment NA NA Human Human +DTXSID3047683 TK.Half.Life NA 3.577 hours 1compartment NA NA Rat Human +DTXSID3047683 Css NA 0.09684 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047683 Css NA 0.3965 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047683 Css NA 0.07477 mg/L PBTK NA 50% Rat Human +DTXSID3047683 Css NA 0.2473 mg/L PBTK NA 95% Rat Human +DTXSID3047687 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047687 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047687 Vd NA 0.4625 L/kg 1compartment NA NA Human Human DTXSID3047687 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047687 TK.Half.Life NA 3.413 hours 1compartment NA NA Human Human -DTXSID3047687 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID3047687 Css NA 6.477 mg/L 3compartmentss NA 95% Human Human -DTXSID3047687 Css NA 0.8255 mg/L PBTK NA 50% Human Human -DTXSID3047687 Css NA 3.964 mg/L PBTK NA 95% Human Human -DTXSID3047687 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047687 Fup NA 0.781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047687 Vd NA 0.4371 L/kg 1compartment NA NA Rat Human +DTXSID3047687 TK.Half.Life NA 3.709 hours 1compartment NA NA Human Human +DTXSID3047687 Css NA 0.9486 mg/L 3compartmentss NA 50% Human Human +DTXSID3047687 Css NA 5.214 mg/L 3compartmentss NA 95% Human Human +DTXSID3047687 Css NA 0.703 mg/L PBTK NA 50% Human Human +DTXSID3047687 Css NA 3.257 mg/L PBTK NA 95% Human Human +DTXSID3047687 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047687 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047687 Vd NA 0.4821 L/kg 1compartment NA NA Rat Human DTXSID3047687 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047687 TK.Half.Life NA 1.234 hours 1compartment NA NA Rat Human -DTXSID3047687 Css NA 0.298 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047687 Css NA 1.658 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047687 Css NA 0.2056 mg/L PBTK NA 50% Rat Human -DTXSID3047687 Css NA 0.9495 mg/L PBTK NA 95% Rat Human -DTXSID3047716 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047716 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047716 Vd NA 0.9508 L/kg 1compartment NA NA Human Human +DTXSID3047687 TK.Half.Life NA 1.317 hours 1compartment NA NA Rat Human +DTXSID3047687 Css NA 0.02423 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047687 Css NA 0.1564 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047687 Css NA 0.01722 mg/L PBTK NA 50% Rat Human +DTXSID3047687 Css NA 0.09647 mg/L PBTK NA 95% Rat Human +DTXSID3047716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047716 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047716 Vd NA 0.7637 L/kg 1compartment NA NA Human Human DTXSID3047716 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047716 TK.Half.Life NA 6.2 hours 1compartment NA NA Human Human -DTXSID3047716 Css NA 0.7892 mg/L 3compartmentss NA 50% Human Human -DTXSID3047716 Css NA 5.437 mg/L 3compartmentss NA 95% Human Human -DTXSID3047716 Css NA 0.6983 mg/L PBTK NA 50% Human Human -DTXSID3047716 Css NA 3.697 mg/L PBTK NA 95% Human Human -DTXSID3047716 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047716 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047716 Vd NA 0.9629 L/kg 1compartment NA NA Rat Human +DTXSID3047716 TK.Half.Life NA 8.624 hours 1compartment NA NA Human Human +DTXSID3047716 Css NA 1.23 mg/L 3compartmentss NA 50% Human Human +DTXSID3047716 Css NA 8.405 mg/L 3compartmentss NA 95% Human Human +DTXSID3047716 Css NA 0.9902 mg/L PBTK NA 50% Human Human +DTXSID3047716 Css NA 5.361 mg/L PBTK NA 95% Human Human +DTXSID3047716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047716 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047716 Vd NA 0.7538 L/kg 1compartment NA NA Rat Human DTXSID3047716 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047716 TK.Half.Life NA 2.127 hours 1compartment NA NA Rat Human -DTXSID3047716 Css NA 0.199 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047716 Css NA 1.251 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047716 Css NA 0.1726 mg/L PBTK NA 50% Rat Human -DTXSID3047716 Css NA 0.7676 mg/L PBTK NA 95% Rat Human -DTXSID3047843 Clint NA 18.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047843 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047843 Vd NA 2.971 L/kg 1compartment NA NA Human Human -DTXSID3047843 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID3047843 TK.Half.Life NA 80.69 hours 1compartment NA NA Human Human -DTXSID3047843 Css NA 3.524 mg/L 3compartmentss NA 50% Human Human -DTXSID3047843 Css NA 23.11 mg/L 3compartmentss NA 95% Human Human -DTXSID3047843 Css NA 2.42 mg/L PBTK NA 50% Human Human -DTXSID3047843 Css NA 15.35 mg/L PBTK NA 95% Human Human -DTXSID3047843 Clint NA 18.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047843 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047843 Vd NA 2.227 L/kg 1compartment NA NA Rat Human -DTXSID3047843 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID3047843 TK.Half.Life NA 13.26 hours 1compartment NA NA Rat Human -DTXSID3047843 Css NA 1.983 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047843 Css NA 10.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047843 Css NA 1.291 mg/L PBTK NA 50% Rat Human -DTXSID3047843 Css NA 6.73 mg/L PBTK NA 95% Rat Human -DTXSID3047845 Clint NA 4.454 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047845 Fup NA 0.7869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047845 Vd NA 3.821 L/kg 1compartment NA NA Human Human +DTXSID3047716 TK.Half.Life NA 2.877 hours 1compartment NA NA Rat Human +DTXSID3047716 Css NA 0.07489 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047716 Css NA 0.4904 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047716 Css NA 0.06006 mg/L PBTK NA 50% Rat Human +DTXSID3047716 Css NA 0.2981 mg/L PBTK NA 95% Rat Human +DTXSID3047843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047843 Fup 0.0775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047843 Vd NA 3.122 L/kg 1compartment NA NA Human Human +DTXSID3047843 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID3047843 TK.Half.Life NA 60.8 hours 1compartment NA NA Human Human +DTXSID3047843 Css NA 2.285 mg/L 3compartmentss NA 50% Human Human +DTXSID3047843 Css NA 14.61 mg/L 3compartmentss NA 95% Human Human +DTXSID3047843 Css NA 1.587 mg/L PBTK NA 50% Human Human +DTXSID3047843 Css NA 9.935 mg/L PBTK NA 95% Human Human +DTXSID3047843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047843 Fup 0.0775 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047843 Vd NA 2.346 L/kg 1compartment NA NA Rat Human +DTXSID3047843 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID3047843 TK.Half.Life NA 8.545 hours 1compartment NA NA Rat Human +DTXSID3047843 Css NA 0.2928 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047843 Css NA 1.647 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047843 Css NA 0.2022 mg/L PBTK NA 50% Rat Human +DTXSID3047843 Css NA 1.092 mg/L PBTK NA 95% Rat Human +DTXSID3047845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047845 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047845 Vd NA 1.234 L/kg 1compartment NA NA Human Human DTXSID3047845 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047845 TK.Half.Life NA 4.621 hours 1compartment NA NA Human Human -DTXSID3047845 Css NA 0.07538 mg/L 3compartmentss NA 50% Human Human -DTXSID3047845 Css NA 0.762 mg/L 3compartmentss NA 95% Human Human -DTXSID3047845 Css NA 0.1023 mg/L PBTK NA 50% Human Human -DTXSID3047845 Css NA 0.65 mg/L PBTK NA 95% Human Human -DTXSID3047845 Clint NA 4.454 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047845 Fup NA 0.7869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047845 Vd NA 3.851 L/kg 1compartment NA NA Rat Human +DTXSID3047845 TK.Half.Life NA 1.185 hours 1compartment NA NA Human Human +DTXSID3047845 Css NA 0.0371 mg/L 3compartmentss NA 50% Human Human +DTXSID3047845 Css NA 0.3349 mg/L 3compartmentss NA 95% Human Human +DTXSID3047845 Css NA 0.03137 mg/L PBTK NA 50% Human Human +DTXSID3047845 Css NA 0.2458 mg/L PBTK NA 95% Human Human +DTXSID3047845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047845 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047845 Vd NA 1.235 L/kg 1compartment NA NA Rat Human DTXSID3047845 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047845 TK.Half.Life NA 2.625 hours 1compartment NA NA Rat Human -DTXSID3047845 Css NA 0.03338 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047845 Css NA 0.3285 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047845 Css NA 0.04664 mg/L PBTK NA 50% Rat Human -DTXSID3047845 Css NA 0.2481 mg/L PBTK NA 95% Rat Human -DTXSID3047847 Clint NA 13.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047847 Fup NA 0.3515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047847 Vd NA 2.362 L/kg 1compartment NA NA Human Human +DTXSID3047845 TK.Half.Life NA 0.6123 hours 1compartment NA NA Rat Human +DTXSID3047845 Css NA 0.004495 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047845 Css NA 0.03334 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047845 Css NA 0.003919 mg/L PBTK NA 50% Rat Human +DTXSID3047845 Css NA 0.0237 mg/L PBTK NA 95% Rat Human +DTXSID3047847 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047847 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047847 Vd NA 1.978 L/kg 1compartment NA NA Human Human DTXSID3047847 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047847 TK.Half.Life NA 3.088 hours 1compartment NA NA Human Human -DTXSID3047847 Css NA 0.07256 mg/L 3compartmentss NA 50% Human Human -DTXSID3047847 Css NA 0.556 mg/L 3compartmentss NA 95% Human Human -DTXSID3047847 Css NA 0.06965 mg/L PBTK NA 50% Human Human -DTXSID3047847 Css NA 0.4451 mg/L PBTK NA 95% Human Human -DTXSID3047847 Clint NA 13.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047847 Fup NA 0.3515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047847 Vd NA 2.333 L/kg 1compartment NA NA Rat Human +DTXSID3047847 TK.Half.Life NA 3.068 hours 1compartment NA NA Human Human +DTXSID3047847 Css NA 0.101 mg/L 3compartmentss NA 50% Human Human +DTXSID3047847 Css NA 0.8698 mg/L 3compartmentss NA 95% Human Human +DTXSID3047847 Css NA 0.09729 mg/L PBTK NA 50% Human Human +DTXSID3047847 Css NA 0.6336 mg/L PBTK NA 95% Human Human +DTXSID3047847 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047847 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047847 Vd NA 1.993 L/kg 1compartment NA NA Rat Human DTXSID3047847 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047847 TK.Half.Life NA 1.673 hours 1compartment NA NA Rat Human -DTXSID3047847 Css NA 0.03813 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047847 Css NA 0.226 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047847 Css NA 0.03605 mg/L PBTK NA 50% Rat Human -DTXSID3047847 Css NA 0.1705 mg/L PBTK NA 95% Rat Human -DTXSID3047849 Clint NA 3.685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047849 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047849 Vd NA 0.5436 L/kg 1compartment NA NA Human Human +DTXSID3047847 TK.Half.Life NA 1.728 hours 1compartment NA NA Rat Human +DTXSID3047847 Css NA 0.01148 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047847 Css NA 0.08001 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047847 Css NA 0.01126 mg/L PBTK NA 50% Rat Human +DTXSID3047847 Css NA 0.05744 mg/L PBTK NA 95% Rat Human +DTXSID3047849 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047849 Fup 0.848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047849 Vd NA 0.5109 L/kg 1compartment NA NA Human Human DTXSID3047849 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047849 TK.Half.Life NA 0.8401 hours 1compartment NA NA Human Human -DTXSID3047849 Css NA 0.1535 mg/L 3compartmentss NA 50% Human Human -DTXSID3047849 Css NA 1.06 mg/L 3compartmentss NA 95% Human Human -DTXSID3047849 Css NA 0.1156 mg/L PBTK NA 50% Human Human -DTXSID3047849 Css NA 0.6901 mg/L PBTK NA 95% Human Human -DTXSID3047849 Clint NA 3.685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047849 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047849 Vd NA 0.5747 L/kg 1compartment NA NA Rat Human +DTXSID3047849 TK.Half.Life NA 3.898 hours 1compartment NA NA Human Human +DTXSID3047849 Css NA 0.9006 mg/L 3compartmentss NA 50% Human Human +DTXSID3047849 Css NA 5.147 mg/L 3compartmentss NA 95% Human Human +DTXSID3047849 Css NA 0.6801 mg/L PBTK NA 50% Human Human +DTXSID3047849 Css NA 3.261 mg/L PBTK NA 95% Human Human +DTXSID3047849 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047849 Fup 0.848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047849 Vd NA 0.5478 L/kg 1compartment NA NA Rat Human DTXSID3047849 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047849 TK.Half.Life NA 0.4652 hours 1compartment NA NA Rat Human -DTXSID3047849 Css NA 0.07001 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047849 Css NA 0.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047849 Css NA 0.05156 mg/L PBTK NA 50% Rat Human -DTXSID3047849 Css NA 0.2563 mg/L PBTK NA 95% Rat Human +DTXSID3047849 TK.Half.Life NA 1.424 hours 1compartment NA NA Rat Human +DTXSID3047849 Css NA 0.02312 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047849 Css NA 0.1537 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047849 Css NA 0.01683 mg/L PBTK NA 50% Rat Human +DTXSID3047849 Css NA 0.09595 mg/L PBTK NA 95% Rat Human DTXSID3047891 Clint 119 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3047891 Fup NA 0.0582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047891 Vd NA 1.865 L/kg 1compartment NA NA Human Human +DTXSID3047891 Fup 0.0502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047891 Vd NA 1.369 L/kg 1compartment NA NA Human Human DTXSID3047891 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047891 TK.Half.Life NA 2.9 hours 1compartment NA NA Human Human -DTXSID3047891 Css NA 0.1122 mg/L 3compartmentss NA 50% Human Human -DTXSID3047891 Css NA 0.8273 mg/L 3compartmentss NA 95% Human Human -DTXSID3047891 Css NA 0.07375 mg/L PBTK NA 50% Human Human -DTXSID3047891 Css NA 0.5156 mg/L PBTK NA 95% Human Human +DTXSID3047891 TK.Half.Life NA 2.143 hours 1compartment NA NA Human Human +DTXSID3047891 Css NA 0.112 mg/L 3compartmentss NA 50% Human Human +DTXSID3047891 Css NA 0.9448 mg/L 3compartmentss NA 95% Human Human +DTXSID3047891 Css NA 0.07082 mg/L PBTK NA 50% Human Human +DTXSID3047891 Css NA 0.5825 mg/L PBTK NA 95% Human Human DTXSID3047891 Clint 119 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3047891 Fup NA 0.0582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047891 Vd NA 1.401 L/kg 1compartment NA NA Rat Human +DTXSID3047891 Fup 0.0502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047891 Vd NA 1.032 L/kg 1compartment NA NA Rat Human DTXSID3047891 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047891 TK.Half.Life NA 0.9851 hours 1compartment NA NA Rat Human -DTXSID3047891 Css NA 0.06436 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047891 Css NA 0.3819 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047891 Css NA 0.03971 mg/L PBTK NA 50% Rat Human -DTXSID3047891 Css NA 0.2293 mg/L PBTK NA 95% Rat Human -DTXSID3047893 Clint NA 13.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047893 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047893 Vd NA 3.104 L/kg 1compartment NA NA Human Human -DTXSID3047893 Days.Css NA 25 Days PBTK NA NA Human Human -DTXSID3047893 TK.Half.Life NA 138.2 hours 1compartment NA NA Human Human -DTXSID3047893 Css NA 5.48 mg/L 3compartmentss NA 50% Human Human -DTXSID3047893 Css NA 33.11 mg/L 3compartmentss NA 95% Human Human -DTXSID3047893 Css NA 3.778 mg/L PBTK NA 50% Human Human -DTXSID3047893 Css NA 22.68 mg/L PBTK NA 95% Human Human -DTXSID3047893 Clint NA 13.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047893 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047893 Vd NA 2.326 L/kg 1compartment NA NA Rat Human -DTXSID3047893 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID3047893 TK.Half.Life NA 18.7 hours 1compartment NA NA Rat Human -DTXSID3047893 Css NA 3.092 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047893 Css NA 13.99 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047893 Css NA 2.049 mg/L PBTK NA 50% Rat Human -DTXSID3047893 Css NA 8.962 mg/L PBTK NA 95% Rat Human -DTXSID3047895 Clint NA 31.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047895 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047895 Vd NA 1.817 L/kg 1compartment NA NA Human Human +DTXSID3047891 TK.Half.Life NA 0.7955 hours 1compartment NA NA Rat Human +DTXSID3047891 Css NA 0.01492 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047891 Css NA 0.1019 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047891 Css NA 0.009271 mg/L PBTK NA 50% Rat Human +DTXSID3047891 Css NA 0.06164 mg/L PBTK NA 95% Rat Human +DTXSID3047893 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047893 Fup 0.00738 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047893 Vd NA 2.376 L/kg 1compartment NA NA Human Human +DTXSID3047893 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3047893 TK.Half.Life NA 46.58 hours 1compartment NA NA Human Human +DTXSID3047893 Css NA 2.882 mg/L 3compartmentss NA 50% Human Human +DTXSID3047893 Css NA 22.95 mg/L 3compartmentss NA 95% Human Human +DTXSID3047893 Css NA 1.872 mg/L PBTK NA 50% Human Human +DTXSID3047893 Css NA 14.42 mg/L PBTK NA 95% Human Human +DTXSID3047893 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047893 Fup 0.00738 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047893 Vd NA 1.767 L/kg 1compartment NA NA Rat Human +DTXSID3047893 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3047893 TK.Half.Life NA 12.29 hours 1compartment NA NA Rat Human +DTXSID3047893 Css NA 0.378 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047893 Css NA 2.447 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047893 Css NA 0.2414 mg/L PBTK NA 50% Rat Human +DTXSID3047893 Css NA 1.511 mg/L PBTK NA 95% Rat Human +DTXSID3047895 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047895 Fup 0.0624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047895 Vd NA 1.947 L/kg 1compartment NA NA Human Human DTXSID3047895 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047895 TK.Half.Life NA 12.37 hours 1compartment NA NA Human Human -DTXSID3047895 Css NA 1.004 mg/L 3compartmentss NA 50% Human Human -DTXSID3047895 Css NA 8.196 mg/L 3compartmentss NA 95% Human Human -DTXSID3047895 Css NA 0.6414 mg/L PBTK NA 50% Human Human -DTXSID3047895 Css NA 5.042 mg/L PBTK NA 95% Human Human -DTXSID3047895 Clint NA 31.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047895 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047895 Vd NA 1.351 L/kg 1compartment NA NA Rat Human +DTXSID3047895 TK.Half.Life NA 8.803 hours 1compartment NA NA Human Human +DTXSID3047895 Css NA 0.5769 mg/L 3compartmentss NA 50% Human Human +DTXSID3047895 Css NA 4.045 mg/L 3compartmentss NA 95% Human Human +DTXSID3047895 Css NA 0.378 mg/L PBTK NA 50% Human Human +DTXSID3047895 Css NA 2.552 mg/L PBTK NA 95% Human Human +DTXSID3047895 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047895 Fup 0.0624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047895 Vd NA 1.467 L/kg 1compartment NA NA Rat Human DTXSID3047895 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047895 TK.Half.Life NA 4.308 hours 1compartment NA NA Rat Human -DTXSID3047895 Css NA 0.5664 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047895 Css NA 3.883 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047895 Css NA 0.3389 mg/L PBTK NA 50% Rat Human -DTXSID3047895 Css NA 2.233 mg/L PBTK NA 95% Rat Human +DTXSID3047895 TK.Half.Life NA 2.965 hours 1compartment NA NA Rat Human +DTXSID3047895 Css NA 0.07308 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047895 Css NA 0.426 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047895 Css NA 0.04719 mg/L PBTK NA 50% Rat Human +DTXSID3047895 Css NA 0.2613 mg/L PBTK NA 95% Rat Human DTXSID3047897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3047897 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047897 Vd NA 0.454 L/kg 1compartment NA NA Human Human +DTXSID3047897 Vd NA 0.4508 L/kg 1compartment NA NA Human Human DTXSID3047897 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047897 TK.Half.Life NA 2.938 hours 1compartment NA NA Human Human -DTXSID3047897 Css NA 0.9466 mg/L 3compartmentss NA 50% Human Human -DTXSID3047897 Css NA 5.769 mg/L 3compartmentss NA 95% Human Human -DTXSID3047897 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID3047897 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID3047897 TK.Half.Life NA 2.917 hours 1compartment NA NA Human Human +DTXSID3047897 Css NA 0.7996 mg/L 3compartmentss NA 50% Human Human +DTXSID3047897 Css NA 5.24 mg/L 3compartmentss NA 95% Human Human +DTXSID3047897 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID3047897 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID3047897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3047897 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047897 Vd NA 0.4859 L/kg 1compartment NA NA Rat Human +DTXSID3047897 Vd NA 0.4832 L/kg 1compartment NA NA Rat Human DTXSID3047897 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047897 TK.Half.Life NA 1.071 hours 1compartment NA NA Rat Human -DTXSID3047897 Css NA 0.2409 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047897 Css NA 1.386 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047897 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID3047897 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID3047920 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047920 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047920 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID3047920 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3047920 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID3047920 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID3047920 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID3047920 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID3047920 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID3047920 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047920 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047920 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID3047920 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047920 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID3047920 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047920 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047920 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID3047920 Css NA 5.483 mg/L PBTK NA 95% Rat Human +DTXSID3047897 TK.Half.Life NA 1.065 hours 1compartment NA NA Rat Human +DTXSID3047897 Css NA 0.01481 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047897 Css NA 0.106 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047897 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID3047897 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID3047922 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3047922 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3047922 Vd NA 0.209 L/kg 1compartment NA NA Human Human +DTXSID3047922 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3047922 TK.Half.Life NA 12.27 hours 1compartment NA NA Human Human +DTXSID3047922 Css NA 7.953 mg/L 3compartmentss NA 50% Human Human +DTXSID3047922 Css NA 37.28 mg/L 3compartmentss NA 95% Human Human +DTXSID3047922 Css NA 4.769 mg/L PBTK NA 50% Human Human +DTXSID3047922 Css NA 21.59 mg/L PBTK NA 95% Human Human +DTXSID3047922 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3047922 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3047922 Vd NA 0.2134 L/kg 1compartment NA NA Rat Human +DTXSID3047922 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3047922 TK.Half.Life NA 4.271 hours 1compartment NA NA Rat Human +DTXSID3047922 Css NA 0.1471 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047922 Css NA 0.9517 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047922 Css NA 0.08354 mg/L PBTK NA 50% Rat Human +DTXSID3047922 Css NA 0.5372 mg/L PBTK NA 95% Rat Human DTXSID3047924 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3047924 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047924 Vd NA 0.4495 L/kg 1compartment NA NA Human Human -DTXSID3047924 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3047924 TK.Half.Life NA 9.523 hours 1compartment NA NA Human Human -DTXSID3047924 Css NA 2.472 mg/L 3compartmentss NA 50% Human Human -DTXSID3047924 Css NA 9.973 mg/L 3compartmentss NA 95% Human Human -DTXSID3047924 Css NA 1.734 mg/L PBTK NA 50% Human Human -DTXSID3047924 Css NA 6.209 mg/L PBTK NA 95% Human Human +DTXSID3047924 Vd NA 1.001 L/kg 1compartment NA NA Human Human +DTXSID3047924 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3047924 TK.Half.Life NA 21.2 hours 1compartment NA NA Human Human +DTXSID3047924 Css NA 1.893 mg/L 3compartmentss NA 50% Human Human +DTXSID3047924 Css NA 8.017 mg/L 3compartmentss NA 95% Human Human +DTXSID3047924 Css NA 1.48 mg/L PBTK NA 50% Human Human +DTXSID3047924 Css NA 5.281 mg/L PBTK NA 95% Human Human DTXSID3047924 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3047924 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047924 Vd NA 0.4613 L/kg 1compartment NA NA Rat Human +DTXSID3047924 Vd NA 1.007 L/kg 1compartment NA NA Rat Human DTXSID3047924 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047924 TK.Half.Life NA 3.331 hours 1compartment NA NA Rat Human -DTXSID3047924 Css NA 0.691 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047924 Css NA 2.255 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047924 Css NA 0.4587 mg/L PBTK NA 50% Rat Human -DTXSID3047924 Css NA 1.315 mg/L PBTK NA 95% Rat Human -DTXSID3047926 Clint NA 356.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047926 Fup NA 0.1157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047926 Vd NA 3.082 L/kg 1compartment NA NA Human Human -DTXSID3047926 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047926 TK.Half.Life NA 4.864 hours 1compartment NA NA Human Human -DTXSID3047926 Css NA 0.09472 mg/L 3compartmentss NA 50% Human Human -DTXSID3047926 Css NA 0.643 mg/L 3compartmentss NA 95% Human Human -DTXSID3047926 Css NA 0.0663 mg/L PBTK NA 50% Human Human -DTXSID3047926 Css NA 0.4381 mg/L PBTK NA 95% Human Human -DTXSID3047926 Clint NA 356.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047926 Fup NA 0.1157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047926 Vd NA 2.313 L/kg 1compartment NA NA Rat Human -DTXSID3047926 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047926 TK.Half.Life NA 1.149 hours 1compartment NA NA Rat Human -DTXSID3047926 Css NA 0.05398 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047926 Css NA 0.2857 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047926 Css NA 0.03592 mg/L PBTK NA 50% Rat Human -DTXSID3047926 Css NA 0.1846 mg/L PBTK NA 95% Rat Human -DTXSID3047970 Clint NA 18.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047970 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047970 Vd NA 0.6595 L/kg 1compartment NA NA Human Human -DTXSID3047970 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047970 TK.Half.Life NA 0.4557 hours 1compartment NA NA Human Human -DTXSID3047970 Css NA 0.01924 mg/L 3compartmentss NA 50% Human Human -DTXSID3047970 Css NA 0.2448 mg/L 3compartmentss NA 95% Human Human -DTXSID3047970 Css NA 0.01546 mg/L PBTK NA 50% Human Human -DTXSID3047970 Css NA 0.1768 mg/L PBTK NA 95% Human Human -DTXSID3047970 Clint NA 18.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047970 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047970 Vd NA 0.7179 L/kg 1compartment NA NA Rat Human -DTXSID3047970 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047970 TK.Half.Life NA 0.2309 hours 1compartment NA NA Rat Human -DTXSID3047970 Css NA 0.009783 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047970 Css NA 0.09674 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047970 Css NA 0.007716 mg/L PBTK NA 50% Rat Human -DTXSID3047970 Css NA 0.0684 mg/L PBTK NA 95% Rat Human +DTXSID3047924 TK.Half.Life NA 7.27 hours 1compartment NA NA Rat Human +DTXSID3047924 Css NA 0.03426 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047924 Css NA 0.2162 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047924 Css NA 0.02562 mg/L PBTK NA 50% Rat Human +DTXSID3047924 Css NA 0.1423 mg/L PBTK NA 95% Rat Human DTXSID3047972 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3047972 Fup NA 0.877 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047972 Vd NA 0.6255 L/kg 1compartment NA NA Human Human +DTXSID3047972 Vd NA 0.6379 L/kg 1compartment NA NA Human Human DTXSID3047972 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3047972 TK.Half.Life NA 4.615 hours 1compartment NA NA Human Human -DTXSID3047972 Css NA 0.9732 mg/L 3compartmentss NA 50% Human Human -DTXSID3047972 Css NA 5.398 mg/L 3compartmentss NA 95% Human Human -DTXSID3047972 Css NA 0.7788 mg/L PBTK NA 50% Human Human -DTXSID3047972 Css NA 3.501 mg/L PBTK NA 95% Human Human +DTXSID3047972 TK.Half.Life NA 4.706 hours 1compartment NA NA Human Human +DTXSID3047972 Css NA 0.8253 mg/L 3compartmentss NA 50% Human Human +DTXSID3047972 Css NA 4.599 mg/L 3compartmentss NA 95% Human Human +DTXSID3047972 Css NA 0.662 mg/L PBTK NA 50% Human Human +DTXSID3047972 Css NA 2.978 mg/L PBTK NA 95% Human Human DTXSID3047972 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3047972 Fup NA 0.877 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047972 Vd NA 0.6759 L/kg 1compartment NA NA Rat Human +DTXSID3047972 Vd NA 0.6857 L/kg 1compartment NA NA Rat Human DTXSID3047972 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3047972 TK.Half.Life NA 1.699 hours 1compartment NA NA Rat Human -DTXSID3047972 Css NA 0.2483 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047972 Css NA 1.345 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047972 Css NA 0.1922 mg/L PBTK NA 50% Rat Human -DTXSID3047972 Css NA 0.8018 mg/L PBTK NA 95% Rat Human -DTXSID3047974 Clint NA 0.3749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047974 Fup NA 0.0351 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3047974 Vd NA 0.5894 L/kg 1compartment NA NA Human Human -DTXSID3047974 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID3047974 TK.Half.Life NA 67.76 hours 1compartment NA NA Human Human -DTXSID3047974 Css NA 19.67 mg/L 3compartmentss NA 50% Human Human -DTXSID3047974 Css NA 88.42 mg/L 3compartmentss NA 95% Human Human -DTXSID3047974 Css NA 11.88 mg/L PBTK NA 50% Human Human -DTXSID3047974 Css NA 52.08 mg/L PBTK NA 95% Human Human -DTXSID3047974 Clint NA 0.3749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047974 Fup NA 0.0351 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3047974 Vd NA 0.4606 L/kg 1compartment NA NA Rat Human -DTXSID3047974 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3047974 TK.Half.Life NA 21.96 hours 1compartment NA NA Rat Human -DTXSID3047974 Css NA 7.167 mg/L 3compartmentss NA 50% Rat Human -DTXSID3047974 Css NA 27.19 mg/L 3compartmentss NA 95% Rat Human -DTXSID3047974 Css NA 4.043 mg/L PBTK NA 50% Rat Human -DTXSID3047974 Css NA 14.85 mg/L PBTK NA 95% Rat Human -DTXSID3048310 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048310 Fup NA 0.7947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048310 Vd NA 0.9279 L/kg 1compartment NA NA Human Human +DTXSID3047972 TK.Half.Life NA 1.724 hours 1compartment NA NA Rat Human +DTXSID3047972 Css NA 0.0153 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047972 Css NA 0.1123 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047972 Css NA 0.01164 mg/L PBTK NA 50% Rat Human +DTXSID3047972 Css NA 0.07294 mg/L PBTK NA 95% Rat Human +DTXSID3047974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047974 Fup 0.037 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3047974 Vd NA 0.6049 L/kg 1compartment NA NA Human Human +DTXSID3047974 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3047974 TK.Half.Life NA 3.265 hours 1compartment NA NA Human Human +DTXSID3047974 Css NA 0.8304 mg/L 3compartmentss NA 50% Human Human +DTXSID3047974 Css NA 7.263 mg/L 3compartmentss NA 95% Human Human +DTXSID3047974 Css NA 0.5011 mg/L PBTK NA 50% Human Human +DTXSID3047974 Css NA 4.278 mg/L PBTK NA 95% Human Human +DTXSID3047974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047974 Fup 0.037 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3047974 Vd NA 0.4725 L/kg 1compartment NA NA Rat Human +DTXSID3047974 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3047974 TK.Half.Life NA 1.575 hours 1compartment NA NA Rat Human +DTXSID3047974 Css NA 0.11 mg/L 3compartmentss NA 50% Rat Human +DTXSID3047974 Css NA 0.7423 mg/L 3compartmentss NA 95% Rat Human +DTXSID3047974 Css NA 0.06416 mg/L PBTK NA 50% Rat Human +DTXSID3047974 Css NA 0.4223 mg/L PBTK NA 95% Rat Human +DTXSID3048287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048287 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3048287 Vd NA 4.95 L/kg 1compartment NA NA Human Human +DTXSID3048287 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048287 TK.Half.Life NA 2.57 hours 1compartment NA NA Human Human +DTXSID3048287 Css NA 0.01422 mg/L 3compartmentss NA 50% Human Human +DTXSID3048287 Css NA 0.1881 mg/L 3compartmentss NA 95% Human Human +DTXSID3048287 Css NA 0.02057 mg/L PBTK NA 50% Human Human +DTXSID3048287 Css NA 0.1874 mg/L PBTK NA 95% Human Human +DTXSID3048287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048287 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3048287 Vd NA 5.008 L/kg 1compartment NA NA Rat Human +DTXSID3048287 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048287 TK.Half.Life NA 1.291 hours 1compartment NA NA Rat Human +DTXSID3048287 Css NA 0.001628 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048287 Css NA 0.01747 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048287 Css NA 0.002558 mg/L PBTK NA 50% Rat Human +DTXSID3048287 Css NA 0.0173 mg/L PBTK NA 95% Rat Human +DTXSID3048289 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID3048289 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3048289 Vd NA 1.359 L/kg 1compartment NA NA Human Human +DTXSID3048289 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID3048289 TK.Half.Life NA 56.63 hours 1compartment NA NA Human Human +DTXSID3048289 Css NA 6.951 mg/L 3compartmentss NA 50% Human Human +DTXSID3048289 Css NA 51.65 mg/L 3compartmentss NA 95% Human Human +DTXSID3048289 Css NA 4.325 mg/L PBTK NA 50% Human Human +DTXSID3048289 Css NA 31.11 mg/L PBTK NA 95% Human Human +DTXSID3048289 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID3048289 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3048289 Vd NA 1.011 L/kg 1compartment NA NA Rat Human +DTXSID3048289 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID3048289 TK.Half.Life NA 21.56 hours 1compartment NA NA Rat Human +DTXSID3048289 Css NA 0.8244 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048289 Css NA 4.921 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048289 Css NA 0.4978 mg/L PBTK NA 50% Rat Human +DTXSID3048289 Css NA 2.818 mg/L PBTK NA 95% Rat Human +DTXSID3048310 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048310 Fup 0.713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048310 Vd NA 0.6771 L/kg 1compartment NA NA Human Human DTXSID3048310 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048310 TK.Half.Life NA 7.669 hours 1compartment NA NA Human Human -DTXSID3048310 Css NA 0.9712 mg/L 3compartmentss NA 50% Human Human -DTXSID3048310 Css NA 6.063 mg/L 3compartmentss NA 95% Human Human -DTXSID3048310 Css NA 0.8311 mg/L PBTK NA 50% Human Human -DTXSID3048310 Css NA 3.946 mg/L PBTK NA 95% Human Human -DTXSID3048310 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048310 Fup NA 0.7947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048310 Vd NA 0.9159 L/kg 1compartment NA NA Rat Human +DTXSID3048310 TK.Half.Life NA 6.15 hours 1compartment NA NA Human Human +DTXSID3048310 Css NA 0.929 mg/L 3compartmentss NA 50% Human Human +DTXSID3048310 Css NA 6.157 mg/L 3compartmentss NA 95% Human Human +DTXSID3048310 Css NA 0.749 mg/L PBTK NA 50% Human Human +DTXSID3048310 Css NA 3.88 mg/L PBTK NA 95% Human Human +DTXSID3048310 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048310 Fup 0.713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048310 Vd NA 0.7004 L/kg 1compartment NA NA Rat Human DTXSID3048310 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048310 TK.Half.Life NA 2.55 hours 1compartment NA NA Rat Human -DTXSID3048310 Css NA 0.2443 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048310 Css NA 1.534 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048310 Css NA 0.2042 mg/L PBTK NA 50% Rat Human -DTXSID3048310 Css NA 0.9282 mg/L PBTK NA 95% Rat Human -DTXSID3048449 Clint NA 33.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048449 Fup NA 0.2959 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048449 Vd NA 1.07 L/kg 1compartment NA NA Human Human -DTXSID3048449 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048449 TK.Half.Life NA 1.115 hours 1compartment NA NA Human Human -DTXSID3048449 Css NA 0.04172 mg/L 3compartmentss NA 50% Human Human -DTXSID3048449 Css NA 0.3297 mg/L 3compartmentss NA 95% Human Human -DTXSID3048449 Css NA 0.03323 mg/L PBTK NA 50% Human Human -DTXSID3048449 Css NA 0.2329 mg/L PBTK NA 95% Human Human -DTXSID3048449 Clint NA 33.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048449 Fup NA 0.2959 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048449 Vd NA 1.048 L/kg 1compartment NA NA Rat Human -DTXSID3048449 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048449 TK.Half.Life NA 0.5645 hours 1compartment NA NA Rat Human -DTXSID3048449 Css NA 0.02294 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048449 Css NA 0.137 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048449 Css NA 0.01746 mg/L PBTK NA 50% Rat Human -DTXSID3048449 Css NA 0.09485 mg/L PBTK NA 95% Rat Human +DTXSID3048310 TK.Half.Life NA 2.166 hours 1compartment NA NA Rat Human +DTXSID3048310 Css NA 0.02427 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048310 Css NA 0.1862 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048310 Css NA 0.01916 mg/L PBTK NA 50% Rat Human +DTXSID3048310 Css NA 0.1183 mg/L PBTK NA 95% Rat Human +DTXSID3048312 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048312 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3048312 Vd NA 0.4232 L/kg 1compartment NA NA Human Human +DTXSID3048312 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048312 TK.Half.Life NA 3.802 hours 1compartment NA NA Human Human +DTXSID3048312 Css NA 0.6486 mg/L 3compartmentss NA 50% Human Human +DTXSID3048312 Css NA 4.125 mg/L 3compartmentss NA 95% Human Human +DTXSID3048312 Css NA 0.4719 mg/L PBTK NA 50% Human Human +DTXSID3048312 Css NA 2.542 mg/L PBTK NA 95% Human Human +DTXSID3048312 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048312 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3048312 Vd NA 0.4428 L/kg 1compartment NA NA Rat Human +DTXSID3048312 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048312 TK.Half.Life NA 1.356 hours 1compartment NA NA Rat Human +DTXSID3048312 Css NA 0.003462 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048312 Css NA 0.0223 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048312 Css NA 0.002396 mg/L PBTK NA 50% Rat Human +DTXSID3048312 Css NA 0.01306 mg/L PBTK NA 95% Rat Human +DTXSID3048318 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048318 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3048318 Vd NA 0.424 L/kg 1compartment NA NA Human Human +DTXSID3048318 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048318 TK.Half.Life NA 5.034 hours 1compartment NA NA Human Human +DTXSID3048318 Css NA 1.931 mg/L 3compartmentss NA 50% Human Human +DTXSID3048318 Css NA 13.94 mg/L 3compartmentss NA 95% Human Human +DTXSID3048318 Css NA 1.179 mg/L PBTK NA 50% Human Human +DTXSID3048318 Css NA 8.138 mg/L PBTK NA 95% Human Human +DTXSID3048318 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048318 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3048318 Vd NA 0.3557 L/kg 1compartment NA NA Rat Human +DTXSID3048318 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048318 TK.Half.Life NA 2.608 hours 1compartment NA NA Rat Human +DTXSID3048318 Css NA 0.2396 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048318 Css NA 1.323 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048318 Css NA 0.1412 mg/L PBTK NA 50% Rat Human +DTXSID3048318 Css NA 0.751 mg/L PBTK NA 95% Rat Human +DTXSID3048449 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048449 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048449 Vd NA 3.351 L/kg 1compartment NA NA Human Human +DTXSID3048449 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3048449 TK.Half.Life NA 45.39 hours 1compartment NA NA Human Human +DTXSID3048449 Css NA 0.8364 mg/L 3compartmentss NA 50% Human Human +DTXSID3048449 Css NA 5.521 mg/L 3compartmentss NA 95% Human Human +DTXSID3048449 Css NA 1.116 mg/L PBTK NA 50% Human Human +DTXSID3048449 Css NA 4.502 mg/L PBTK NA 95% Human Human +DTXSID3048449 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048449 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048449 Vd NA 3.345 L/kg 1compartment NA NA Rat Human +DTXSID3048449 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3048449 TK.Half.Life NA 15.41 hours 1compartment NA NA Rat Human +DTXSID3048449 Css NA 0.05069 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048449 Css NA 0.3165 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048449 Css NA 0.06991 mg/L PBTK NA 50% Rat Human +DTXSID3048449 Css NA 0.2498 mg/L PBTK NA 95% Rat Human +DTXSID3048491 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048491 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3048491 Vd NA 2.85 L/kg 1compartment NA NA Human Human +DTXSID3048491 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048491 TK.Half.Life NA 11.19 hours 1compartment NA NA Human Human +DTXSID3048491 Css NA 0.2576 mg/L 3compartmentss NA 50% Human Human +DTXSID3048491 Css NA 1.438 mg/L 3compartmentss NA 95% Human Human +DTXSID3048491 Css NA 0.27 mg/L PBTK NA 50% Human Human +DTXSID3048491 Css NA 1.509 mg/L PBTK NA 95% Human Human +DTXSID3048491 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048491 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3048491 Vd NA 2.203 L/kg 1compartment NA NA Rat Human +DTXSID3048491 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048491 TK.Half.Life NA 2.414 hours 1compartment NA NA Rat Human +DTXSID3048491 Css NA 0.01134 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048491 Css NA 0.06623 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048491 Css NA 0.01208 mg/L PBTK NA 50% Rat Human +DTXSID3048491 Css NA 0.07155 mg/L PBTK NA 95% Rat Human +DTXSID3048493 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048493 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3048493 Vd NA 0.5617 L/kg 1compartment NA NA Human Human +DTXSID3048493 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048493 TK.Half.Life NA 0.7419 hours 1compartment NA NA Human Human +DTXSID3048493 Css NA 0.1016 mg/L 3compartmentss NA 50% Human Human +DTXSID3048493 Css NA 0.8403 mg/L 3compartmentss NA 95% Human Human +DTXSID3048493 Css NA 0.07543 mg/L PBTK NA 50% Human Human +DTXSID3048493 Css NA 0.5485 mg/L PBTK NA 95% Human Human +DTXSID3048493 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048493 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3048493 Vd NA 0.5923 L/kg 1compartment NA NA Rat Human +DTXSID3048493 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048493 TK.Half.Life NA 0.3894 hours 1compartment NA NA Rat Human +DTXSID3048493 Css NA 0.01067 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048493 Css NA 0.07373 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048493 Css NA 0.008126 mg/L PBTK NA 50% Rat Human +DTXSID3048493 Css NA 0.04571 mg/L PBTK NA 95% Rat Human +DTXSID3048495 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048495 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID3048495 Vd NA 0.656 L/kg 1compartment NA NA Human Human +DTXSID3048495 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048495 TK.Half.Life NA 1.632 hours 1compartment NA NA Human Human +DTXSID3048495 Css NA 0.1768 mg/L 3compartmentss NA 50% Human Human +DTXSID3048495 Css NA 1.179 mg/L 3compartmentss NA 95% Human Human +DTXSID3048495 Css NA 0.1378 mg/L PBTK NA 50% Human Human +DTXSID3048495 Css NA 0.81 mg/L PBTK NA 95% Human Human +DTXSID3048495 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048495 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID3048495 Vd NA 0.6526 L/kg 1compartment NA NA Rat Human +DTXSID3048495 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048495 TK.Half.Life NA 0.9359 hours 1compartment NA NA Rat Human +DTXSID3048495 Css NA 0.007635 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048495 Css NA 0.05993 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048495 Css NA 0.005975 mg/L PBTK NA 50% Rat Human +DTXSID3048495 Css NA 0.04061 mg/L PBTK NA 95% Rat Human DTXSID3048520 Clint 6.26 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID3048520 Fup 0.48 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID3048520 Vd NA 1.674 L/kg 1compartment NA NA Human Human +DTXSID3048520 Vd NA 1.592 L/kg 1compartment NA NA Human Human DTXSID3048520 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048520 TK.Half.Life NA 3.373 hours 1compartment NA NA Human Human -DTXSID3048520 Css NA 0.1414 mg/L 3compartmentss NA 50% Human Human -DTXSID3048520 Css NA 0.739 mg/L 3compartmentss NA 95% Human Human -DTXSID3048520 Css NA 0.1187 mg/L PBTK NA 50% Human Human -DTXSID3048520 Css NA 0.5568 mg/L PBTK NA 95% Human Human +DTXSID3048520 TK.Half.Life NA 3.135 hours 1compartment NA NA Human Human +DTXSID3048520 Css NA 0.12 mg/L 3compartmentss NA 50% Human Human +DTXSID3048520 Css NA 0.6339 mg/L 3compartmentss NA 95% Human Human +DTXSID3048520 Css NA 0.1005 mg/L PBTK NA 50% Human Human +DTXSID3048520 Css NA 0.4956 mg/L PBTK NA 95% Human Human DTXSID3048520 Clint 6.26 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID3048520 Fup 0.48 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID3048520 Vd NA 1.385 L/kg 1compartment NA NA Rat Human +DTXSID3048520 Vd NA 1.327 L/kg 1compartment NA NA Rat Human DTXSID3048520 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048520 TK.Half.Life NA 1.348 hours 1compartment NA NA Rat Human -DTXSID3048520 Css NA 0.07157 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048520 Css NA 0.253 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048520 Css NA 0.05864 mg/L PBTK NA 50% Rat Human -DTXSID3048520 Css NA 0.1925 mg/L PBTK NA 95% Rat Human -DTXSID3048522 Clint NA 294.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048522 Fup NA 0.0237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048522 Vd NA 5.76 L/kg 1compartment NA NA Human Human +DTXSID3048520 TK.Half.Life NA 1.285 hours 1compartment NA NA Rat Human +DTXSID3048520 Css NA 0.006438 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048520 Css NA 0.03151 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048520 Css NA 0.00551 mg/L PBTK NA 50% Rat Human +DTXSID3048520 Css NA 0.02396 mg/L PBTK NA 95% Rat Human +DTXSID3048522 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048522 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048522 Vd NA 0.2411 L/kg 1compartment NA NA Human Human DTXSID3048522 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048522 TK.Half.Life NA 16.17 hours 1compartment NA NA Human Human -DTXSID3048522 Css NA 0.2082 mg/L 3compartmentss NA 50% Human Human -DTXSID3048522 Css NA 1.164 mg/L 3compartmentss NA 95% Human Human -DTXSID3048522 Css NA 0.1805 mg/L PBTK NA 50% Human Human -DTXSID3048522 Css NA 0.9782 mg/L PBTK NA 95% Human Human -DTXSID3048522 Clint NA 294.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048522 Fup NA 0.0237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048522 Vd NA 4.426 L/kg 1compartment NA NA Rat Human +DTXSID3048522 TK.Half.Life NA 0.773 hours 1compartment NA NA Human Human +DTXSID3048522 Css NA 0.3866 mg/L 3compartmentss NA 50% Human Human +DTXSID3048522 Css NA 2.869 mg/L 3compartmentss NA 95% Human Human +DTXSID3048522 Css NA 0.2357 mg/L PBTK NA 50% Human Human +DTXSID3048522 Css NA 1.706 mg/L PBTK NA 95% Human Human +DTXSID3048522 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048522 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048522 Vd NA 0.2495 L/kg 1compartment NA NA Rat Human DTXSID3048522 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048522 TK.Half.Life NA 2.894 hours 1compartment NA NA Rat Human -DTXSID3048522 Css NA 0.1155 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048522 Css NA 0.4996 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048522 Css NA 0.0971 mg/L PBTK NA 50% Rat Human -DTXSID3048522 Css NA 0.4124 mg/L PBTK NA 95% Rat Human -DTXSID3048574 Clint NA 0.2424 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048574 Fup NA 0.5799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048574 Vd NA 2.421 L/kg 1compartment NA NA Human Human -DTXSID3048574 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID3048574 TK.Half.Life NA 40.39 hours 1compartment NA NA Human Human -DTXSID3048574 Css NA 1.689 mg/L 3compartmentss NA 50% Human Human -DTXSID3048574 Css NA 7.49 mg/L 3compartmentss NA 95% Human Human -DTXSID3048574 Css NA 1.414 mg/L PBTK NA 50% Human Human -DTXSID3048574 Css NA 5.07 mg/L PBTK NA 95% Human Human -DTXSID3048574 Clint NA 0.2424 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048574 Fup NA 0.5799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048574 Vd NA 1.921 L/kg 1compartment NA NA Rat Human -DTXSID3048574 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3048574 TK.Half.Life NA 7.666 hours 1compartment NA NA Rat Human -DTXSID3048574 Css NA 0.5478 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048574 Css NA 2.292 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048574 Css NA 0.4446 mg/L PBTK NA 50% Rat Human -DTXSID3048574 Css NA 1.434 mg/L PBTK NA 95% Rat Human -DTXSID3048576 Clint NA 1.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048576 Fup NA 0.1321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048576 Vd NA 0.3274 L/kg 1compartment NA NA Human Human +DTXSID3048522 TK.Half.Life NA 0.4797 hours 1compartment NA NA Rat Human +DTXSID3048522 Css NA 0.04909 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048522 Css NA 0.2833 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048522 Css NA 0.0292 mg/L PBTK NA 50% Rat Human +DTXSID3048522 Css NA 0.1642 mg/L PBTK NA 95% Rat Human +DTXSID3048574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048574 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048574 Vd NA 1.77 L/kg 1compartment NA NA Human Human +DTXSID3048574 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048574 TK.Half.Life NA 2.858 hours 1compartment NA NA Human Human +DTXSID3048574 Css NA 0.1033 mg/L 3compartmentss NA 50% Human Human +DTXSID3048574 Css NA 0.7035 mg/L 3compartmentss NA 95% Human Human +DTXSID3048574 Css NA 0.07656 mg/L PBTK NA 50% Human Human +DTXSID3048574 Css NA 0.4857 mg/L PBTK NA 95% Human Human +DTXSID3048574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048574 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048574 Vd NA 1.393 L/kg 1compartment NA NA Rat Human +DTXSID3048574 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048574 TK.Half.Life NA 1.054 hours 1compartment NA NA Rat Human +DTXSID3048574 Css NA 0.01294 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048574 Css NA 0.06805 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048574 Css NA 0.009612 mg/L PBTK NA 50% Rat Human +DTXSID3048574 Css NA 0.04738 mg/L PBTK NA 95% Rat Human +DTXSID3048576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048576 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048576 Vd NA 0.3974 L/kg 1compartment NA NA Human Human DTXSID3048576 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048576 TK.Half.Life NA 4.234 hours 1compartment NA NA Human Human -DTXSID3048576 Css NA 1.904 mg/L 3compartmentss NA 50% Human Human -DTXSID3048576 Css NA 10.76 mg/L 3compartmentss NA 95% Human Human -DTXSID3048576 Css NA 1.21 mg/L PBTK NA 50% Human Human -DTXSID3048576 Css NA 6.475 mg/L PBTK NA 95% Human Human -DTXSID3048576 Clint NA 1.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048576 Fup NA 0.1321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048576 Vd NA 0.3224 L/kg 1compartment NA NA Rat Human +DTXSID3048576 TK.Half.Life NA 0.6313 hours 1compartment NA NA Human Human +DTXSID3048576 Css NA 0.04749 mg/L 3compartmentss NA 50% Human Human +DTXSID3048576 Css NA 0.4105 mg/L 3compartmentss NA 95% Human Human +DTXSID3048576 Css NA 0.03202 mg/L PBTK NA 50% Human Human +DTXSID3048576 Css NA 0.2617 mg/L PBTK NA 95% Human Human +DTXSID3048576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048576 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048576 Vd NA 0.3932 L/kg 1compartment NA NA Rat Human DTXSID3048576 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048576 TK.Half.Life NA 2.261 hours 1compartment NA NA Rat Human -DTXSID3048576 Css NA 0.8688 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048576 Css NA 3.841 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048576 Css NA 0.5219 mg/L PBTK NA 50% Rat Human -DTXSID3048576 Css NA 2.143 mg/L PBTK NA 95% Rat Human -DTXSID3048578 Clint NA 1.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048578 Fup NA 0.2779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048578 Vd NA 0.344 L/kg 1compartment NA NA Human Human +DTXSID3048576 TK.Half.Life NA 0.344 hours 1compartment NA NA Rat Human +DTXSID3048576 Css NA 0.0004456 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048576 Css NA 0.003678 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048576 Css NA 0.0002907 mg/L PBTK NA 50% Rat Human +DTXSID3048576 Css NA 0.002244 mg/L PBTK NA 95% Rat Human +DTXSID3048578 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048578 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048578 Vd NA 0.2477 L/kg 1compartment NA NA Human Human DTXSID3048578 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048578 TK.Half.Life NA 2.91 hours 1compartment NA NA Human Human -DTXSID3048578 Css NA 1.012 mg/L 3compartmentss NA 50% Human Human -DTXSID3048578 Css NA 4.548 mg/L 3compartmentss NA 95% Human Human -DTXSID3048578 Css NA 0.6705 mg/L PBTK NA 50% Human Human -DTXSID3048578 Css NA 2.763 mg/L PBTK NA 95% Human Human -DTXSID3048578 Clint NA 1.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048578 Fup NA 0.2779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048578 Vd NA 0.3451 L/kg 1compartment NA NA Rat Human +DTXSID3048578 TK.Half.Life NA 9.003 hours 1compartment NA NA Human Human +DTXSID3048578 Css NA 2.513 mg/L 3compartmentss NA 50% Human Human +DTXSID3048578 Css NA 9.652 mg/L 3compartmentss NA 95% Human Human +DTXSID3048578 Css NA 1.562 mg/L PBTK NA 50% Human Human +DTXSID3048578 Css NA 5.73 mg/L PBTK NA 95% Human Human +DTXSID3048578 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048578 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048578 Vd NA 0.254 L/kg 1compartment NA NA Rat Human DTXSID3048578 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048578 TK.Half.Life NA 1.462 hours 1compartment NA NA Rat Human -DTXSID3048578 Css NA 0.424 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048578 Css NA 1.423 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048578 Css NA 0.2652 mg/L PBTK NA 50% Rat Human -DTXSID3048578 Css NA 0.8132 mg/L PBTK NA 95% Rat Human -DTXSID3048601 Clint NA 23.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3048578 TK.Half.Life NA 3.146 hours 1compartment NA NA Rat Human +DTXSID3048578 Css NA 0.01386 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048578 Css NA 0.05156 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048578 Css NA 0.008122 mg/L PBTK NA 50% Rat Human +DTXSID3048578 Css NA 0.02915 mg/L PBTK NA 95% Rat Human +DTXSID3048601 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3048601 Fup 0.042 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3048601 Vd NA 0.2123 L/kg 1compartment NA NA Human Human -DTXSID3048601 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048601 TK.Half.Life NA 0.9817 hours 1compartment NA NA Human Human -DTXSID3048601 Css NA 0.7211 mg/L 3compartmentss NA 50% Human Human -DTXSID3048601 Css NA 5.968 mg/L 3compartmentss NA 95% Human Human -DTXSID3048601 Css NA 0.4292 mg/L PBTK NA 50% Human Human -DTXSID3048601 Css NA 3.517 mg/L PBTK NA 95% Human Human -DTXSID3048601 Clint NA 23.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3048601 Vd NA 0.2121 L/kg 1compartment NA NA Human Human +DTXSID3048601 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID3048601 TK.Half.Life NA 32.66 hours 1compartment NA NA Human Human +DTXSID3048601 Css NA 23.54 mg/L 3compartmentss NA 50% Human Human +DTXSID3048601 Css NA 106.4 mg/L 3compartmentss NA 95% Human Human +DTXSID3048601 Css NA 13.99 mg/L PBTK NA 50% Human Human +DTXSID3048601 Css NA 62.51 mg/L PBTK NA 95% Human Human +DTXSID3048601 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3048601 Fup 0.042 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3048601 Vd NA 0.2125 L/kg 1compartment NA NA Rat Human -DTXSID3048601 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048601 TK.Half.Life NA 0.6205 hours 1compartment NA NA Rat Human -DTXSID3048601 Css NA 0.4094 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048601 Css NA 2.509 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048601 Css NA 0.227 mg/L PBTK NA 50% Rat Human -DTXSID3048601 Css NA 1.373 mg/L PBTK NA 95% Rat Human -DTXSID3048603 Clint NA 66.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048603 Fup NA 0.0756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048603 Vd NA 2.446 L/kg 1compartment NA NA Human Human +DTXSID3048601 Vd NA 0.2123 L/kg 1compartment NA NA Rat Human +DTXSID3048601 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3048601 TK.Half.Life NA 11.15 hours 1compartment NA NA Rat Human +DTXSID3048601 Css NA 0.5743 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048601 Css NA 3.505 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048601 Css NA 0.3258 mg/L PBTK NA 50% Rat Human +DTXSID3048601 Css NA 1.971 mg/L PBTK NA 95% Rat Human +DTXSID3048603 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048603 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048603 Vd NA 1.964 L/kg 1compartment NA NA Human Human DTXSID3048603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048603 TK.Half.Life NA 5.497 hours 1compartment NA NA Human Human -DTXSID3048603 Css NA 0.2058 mg/L 3compartmentss NA 50% Human Human -DTXSID3048603 Css NA 1.47 mg/L 3compartmentss NA 95% Human Human -DTXSID3048603 Css NA 0.1406 mg/L PBTK NA 50% Human Human -DTXSID3048603 Css NA 0.9613 mg/L PBTK NA 95% Human Human -DTXSID3048603 Clint NA 66.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048603 Fup NA 0.0756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048603 Vd NA 1.838 L/kg 1compartment NA NA Rat Human +DTXSID3048603 TK.Half.Life NA 7.665 hours 1compartment NA NA Human Human +DTXSID3048603 Css NA 0.4585 mg/L 3compartmentss NA 50% Human Human +DTXSID3048603 Css NA 3.149 mg/L 3compartmentss NA 95% Human Human +DTXSID3048603 Css NA 0.3068 mg/L PBTK NA 50% Human Human +DTXSID3048603 Css NA 2.005 mg/L PBTK NA 95% Human Human +DTXSID3048603 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048603 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048603 Vd NA 1.481 L/kg 1compartment NA NA Rat Human DTXSID3048603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048603 TK.Half.Life NA 1.559 hours 1compartment NA NA Rat Human -DTXSID3048603 Css NA 0.1167 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048603 Css NA 0.6702 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048603 Css NA 0.07533 mg/L PBTK NA 50% Rat Human -DTXSID3048603 Css NA 0.4194 mg/L PBTK NA 95% Rat Human -DTXSID3048605 Clint NA 135.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048605 Fup NA 0.5454 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048605 Vd NA 0.7881 L/kg 1compartment NA NA Human Human -DTXSID3048605 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048605 TK.Half.Life NA 0.5554 hours 1compartment NA NA Human Human -DTXSID3048605 Css NA 0.006226 mg/L 3compartmentss NA 50% Human Human -DTXSID3048605 Css NA 0.0655 mg/L 3compartmentss NA 95% Human Human -DTXSID3048605 Css NA 0.004967 mg/L PBTK NA 50% Human Human -DTXSID3048605 Css NA 0.04553 mg/L PBTK NA 95% Human Human -DTXSID3048605 Clint NA 135.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048605 Fup NA 0.5454 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048605 Vd NA 0.7845 L/kg 1compartment NA NA Rat Human +DTXSID3048603 TK.Half.Life NA 2.558 hours 1compartment NA NA Rat Human +DTXSID3048603 Css NA 0.05928 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048603 Css NA 0.3273 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048603 Css NA 0.0389 mg/L PBTK NA 50% Rat Human +DTXSID3048603 Css NA 0.2037 mg/L PBTK NA 95% Rat Human +DTXSID3048605 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048605 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048605 Vd NA 0.9267 L/kg 1compartment NA NA Human Human +DTXSID3048605 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3048605 TK.Half.Life NA 10.39 hours 1compartment NA NA Human Human +DTXSID3048605 Css NA 1.05 mg/L 3compartmentss NA 50% Human Human +DTXSID3048605 Css NA 7.177 mg/L 3compartmentss NA 95% Human Human +DTXSID3048605 Css NA 0.8736 mg/L PBTK NA 50% Human Human +DTXSID3048605 Css NA 4.57 mg/L PBTK NA 95% Human Human +DTXSID3048605 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048605 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048605 Vd NA 0.9045 L/kg 1compartment NA NA Rat Human DTXSID3048605 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048605 TK.Half.Life NA 0.2477 hours 1compartment NA NA Rat Human -DTXSID3048605 Css NA 0.003435 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048605 Css NA 0.03052 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048605 Css NA 0.00263 mg/L PBTK NA 50% Rat Human -DTXSID3048605 Css NA 0.01988 mg/L PBTK NA 95% Rat Human -DTXSID3048607 Clint NA 13.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048607 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048607 Vd NA 1.805 L/kg 1compartment NA NA Human Human -DTXSID3048607 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3048607 TK.Half.Life NA 17.7 hours 1compartment NA NA Human Human -DTXSID3048607 Css NA 1.516 mg/L 3compartmentss NA 50% Human Human -DTXSID3048607 Css NA 10.07 mg/L 3compartmentss NA 95% Human Human -DTXSID3048607 Css NA 0.9768 mg/L PBTK NA 50% Human Human -DTXSID3048607 Css NA 6.231 mg/L PBTK NA 95% Human Human -DTXSID3048607 Clint NA 13.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048607 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048607 Vd NA 1.348 L/kg 1compartment NA NA Rat Human -DTXSID3048607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048607 TK.Half.Life NA 6.134 hours 1compartment NA NA Rat Human -DTXSID3048607 Css NA 0.8408 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048607 Css NA 4.498 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048607 Css NA 0.507 mg/L PBTK NA 50% Rat Human -DTXSID3048607 Css NA 2.626 mg/L PBTK NA 95% Rat Human -DTXSID3048609 Clint NA 11.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048609 Fup NA 0.886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048609 Vd NA 1.746 L/kg 1compartment NA NA Human Human +DTXSID3048605 TK.Half.Life NA 3.411 hours 1compartment NA NA Rat Human +DTXSID3048605 Css NA 0.02686 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048605 Css NA 0.2269 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048605 Css NA 0.02212 mg/L PBTK NA 50% Rat Human +DTXSID3048605 Css NA 0.1442 mg/L PBTK NA 95% Rat Human +DTXSID3048607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048607 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048607 Vd NA 2.696 L/kg 1compartment NA NA Human Human +DTXSID3048607 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3048607 TK.Half.Life NA 34.18 hours 1compartment NA NA Human Human +DTXSID3048607 Css NA 1.675 mg/L 3compartmentss NA 50% Human Human +DTXSID3048607 Css NA 11.99 mg/L 3compartmentss NA 95% Human Human +DTXSID3048607 Css NA 1.126 mg/L PBTK NA 50% Human Human +DTXSID3048607 Css NA 7.689 mg/L PBTK NA 95% Human Human +DTXSID3048607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048607 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048607 Vd NA 2.016 L/kg 1compartment NA NA Rat Human +DTXSID3048607 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3048607 TK.Half.Life NA 7.37 hours 1compartment NA NA Rat Human +DTXSID3048607 Css NA 0.2172 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048607 Css NA 1.307 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048607 Css NA 0.1439 mg/L PBTK NA 50% Rat Human +DTXSID3048607 Css NA 0.8238 mg/L PBTK NA 95% Rat Human +DTXSID3048609 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048609 Fup 0.647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048609 Vd NA 0.5184 L/kg 1compartment NA NA Human Human DTXSID3048609 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048609 TK.Half.Life NA 1.282 hours 1compartment NA NA Human Human -DTXSID3048609 Css NA 0.03683 mg/L 3compartmentss NA 50% Human Human -DTXSID3048609 Css NA 0.3947 mg/L 3compartmentss NA 95% Human Human -DTXSID3048609 Css NA 0.03932 mg/L PBTK NA 50% Human Human -DTXSID3048609 Css NA 0.3135 mg/L PBTK NA 95% Human Human -DTXSID3048609 Clint NA 11.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048609 Fup NA 0.886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048609 Vd NA 1.763 L/kg 1compartment NA NA Rat Human +DTXSID3048609 TK.Half.Life NA 5.184 hours 1compartment NA NA Human Human +DTXSID3048609 Css NA 1.07 mg/L 3compartmentss NA 50% Human Human +DTXSID3048609 Css NA 6.638 mg/L 3compartmentss NA 95% Human Human +DTXSID3048609 Css NA 0.8 mg/L PBTK NA 50% Human Human +DTXSID3048609 Css NA 4.173 mg/L PBTK NA 95% Human Human +DTXSID3048609 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048609 Fup 0.647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048609 Vd NA 0.544 L/kg 1compartment NA NA Rat Human DTXSID3048609 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048609 TK.Half.Life NA 0.6782 hours 1compartment NA NA Rat Human -DTXSID3048609 Css NA 0.01781 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048609 Css NA 0.1483 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048609 Css NA 0.01939 mg/L PBTK NA 50% Rat Human -DTXSID3048609 Css NA 0.1151 mg/L PBTK NA 95% Rat Human -DTXSID3048653 Clint NA 102.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3048609 TK.Half.Life NA 1.854 hours 1compartment NA NA Rat Human +DTXSID3048609 Css NA 0.02794 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048609 Css NA 0.1931 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048609 Css NA 0.02042 mg/L PBTK NA 50% Rat Human +DTXSID3048609 Css NA 0.1196 mg/L PBTK NA 95% Rat Human +DTXSID3048653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3048653 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3048653 Vd NA 10.2 L/kg 1compartment NA NA Human Human -DTXSID3048653 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID3048653 TK.Half.Life NA 67.82 hours 1compartment NA NA Human Human -DTXSID3048653 Css NA 0.4326 mg/L 3compartmentss NA 50% Human Human -DTXSID3048653 Css NA 2.593 mg/L 3compartmentss NA 95% Human Human -DTXSID3048653 Css NA 0.5195 mg/L PBTK NA 50% Human Human -DTXSID3048653 Css NA 2.914 mg/L PBTK NA 95% Human Human -DTXSID3048653 Clint NA 102.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3048653 Vd NA 8.364 L/kg 1compartment NA NA Human Human +DTXSID3048653 Days.Css NA 50 Days PBTK NA NA Human Human +DTXSID3048653 TK.Half.Life NA 248.4 hours 1compartment NA NA Human Human +DTXSID3048653 Css NA 2.248 mg/L 3compartmentss NA 50% Human Human +DTXSID3048653 Css NA 14.07 mg/L 3compartmentss NA 95% Human Human +DTXSID3048653 Css NA 2.379 mg/L PBTK NA 50% Human Human +DTXSID3048653 Css NA 14.06 mg/L PBTK NA 95% Human Human +DTXSID3048653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3048653 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3048653 Vd NA 8.041 L/kg 1compartment NA NA Rat Human -DTXSID3048653 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID3048653 TK.Half.Life NA 10.14 hours 1compartment NA NA Rat Human -DTXSID3048653 Css NA 0.2346 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048653 Css NA 1.029 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048653 Css NA 0.2815 mg/L PBTK NA 50% Rat Human -DTXSID3048653 Css NA 1.195 mg/L PBTK NA 95% Rat Human -DTXSID3048655 Clint NA 1.755 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048655 Fup NA 0.9248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048655 Vd NA 7.897 L/kg 1compartment NA NA Human Human -DTXSID3048655 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3048655 TK.Half.Life NA 24.54 hours 1compartment NA NA Human Human -DTXSID3048655 Css NA 0.1354 mg/L 3compartmentss NA 50% Human Human -DTXSID3048655 Css NA 0.7527 mg/L 3compartmentss NA 95% Human Human -DTXSID3048655 Css NA 0.2616 mg/L PBTK NA 50% Human Human -DTXSID3048655 Css NA 1.095 mg/L PBTK NA 95% Human Human -DTXSID3048655 Clint NA 1.755 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048655 Fup NA 0.9248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048655 Vd NA 7.837 L/kg 1compartment NA NA Rat Human -DTXSID3048655 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3048655 TK.Half.Life NA 7.904 hours 1compartment NA NA Rat Human -DTXSID3048655 Css NA 0.05837 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048655 Css NA 0.2632 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048655 Css NA 0.1182 mg/L PBTK NA 50% Rat Human -DTXSID3048655 Css NA 0.3468 mg/L PBTK NA 95% Rat Human -DTXSID3048657 Clint NA 19.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048657 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048657 Vd NA 3.265 L/kg 1compartment NA NA Human Human -DTXSID3048657 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID3048657 TK.Half.Life NA 108.8 hours 1compartment NA NA Human Human -DTXSID3048657 Css NA 3.819 mg/L 3compartmentss NA 50% Human Human -DTXSID3048657 Css NA 22.53 mg/L 3compartmentss NA 95% Human Human -DTXSID3048657 Css NA 2.682 mg/L PBTK NA 50% Human Human -DTXSID3048657 Css NA 15.75 mg/L PBTK NA 95% Human Human -DTXSID3048657 Clint NA 19.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048657 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048657 Vd NA 2.45 L/kg 1compartment NA NA Rat Human -DTXSID3048657 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID3048657 TK.Half.Life NA 14.64 hours 1compartment NA NA Rat Human -DTXSID3048657 Css NA 2.185 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048657 Css NA 9.018 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048657 Css NA 1.47 mg/L PBTK NA 50% Rat Human -DTXSID3048657 Css NA 6.064 mg/L PBTK NA 95% Rat Human -DTXSID3048659 Clint NA 4.639 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048659 Fup NA 0.3718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048659 Vd NA 2.656 L/kg 1compartment NA NA Human Human +DTXSID3048653 Vd NA 6.533 L/kg 1compartment NA NA Rat Human +DTXSID3048653 Days.Css NA 30 Days PBTK NA NA Rat Human +DTXSID3048653 TK.Half.Life NA 34.13 hours 1compartment NA NA Rat Human +DTXSID3048653 Css NA 0.2858 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048653 Css NA 1.339 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048653 Css NA 0.3102 mg/L PBTK NA 50% Rat Human +DTXSID3048653 Css NA 1.494 mg/L PBTK NA 95% Rat Human +DTXSID3048655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048655 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048655 Vd NA 1.121 L/kg 1compartment NA NA Human Human +DTXSID3048655 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048655 TK.Half.Life NA 2.574 hours 1compartment NA NA Human Human +DTXSID3048655 Css NA 0.2278 mg/L 3compartmentss NA 50% Human Human +DTXSID3048655 Css NA 1.887 mg/L 3compartmentss NA 95% Human Human +DTXSID3048655 Css NA 0.1589 mg/L PBTK NA 50% Human Human +DTXSID3048655 Css NA 1.214 mg/L PBTK NA 95% Human Human +DTXSID3048655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048655 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048655 Vd NA 1.11 L/kg 1compartment NA NA Rat Human +DTXSID3048655 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048655 TK.Half.Life NA 1.517 hours 1compartment NA NA Rat Human +DTXSID3048655 Css NA 0.02905 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048655 Css NA 0.1942 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048655 Css NA 0.01992 mg/L PBTK NA 50% Rat Human +DTXSID3048655 Css NA 0.1221 mg/L PBTK NA 95% Rat Human +DTXSID3048657 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048657 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048657 Vd NA 0.3398 L/kg 1compartment NA NA Human Human +DTXSID3048657 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048657 TK.Half.Life NA 0.8448 hours 1compartment NA NA Human Human +DTXSID3048657 Css NA 0.267 mg/L 3compartmentss NA 50% Human Human +DTXSID3048657 Css NA 2.184 mg/L 3compartmentss NA 95% Human Human +DTXSID3048657 Css NA 0.1659 mg/L PBTK NA 50% Human Human +DTXSID3048657 Css NA 1.304 mg/L PBTK NA 95% Human Human +DTXSID3048657 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048657 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048657 Vd NA 0.3289 L/kg 1compartment NA NA Rat Human +DTXSID3048657 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048657 TK.Half.Life NA 0.4817 hours 1compartment NA NA Rat Human +DTXSID3048657 Css NA 0.03506 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048657 Css NA 0.2121 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048657 Css NA 0.02106 mg/L PBTK NA 50% Rat Human +DTXSID3048657 Css NA 0.1232 mg/L PBTK NA 95% Rat Human +DTXSID3048659 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048659 Fup 0.463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048659 Vd NA 2.594 L/kg 1compartment NA NA Human Human DTXSID3048659 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048659 TK.Half.Life NA 5.747 hours 1compartment NA NA Human Human -DTXSID3048659 Css NA 0.1387 mg/L 3compartmentss NA 50% Human Human -DTXSID3048659 Css NA 0.9804 mg/L 3compartmentss NA 95% Human Human -DTXSID3048659 Css NA 0.1571 mg/L PBTK NA 50% Human Human -DTXSID3048659 Css NA 0.8701 mg/L PBTK NA 95% Human Human -DTXSID3048659 Clint NA 4.639 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048659 Fup NA 0.3718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048659 Vd NA 2.638 L/kg 1compartment NA NA Rat Human +DTXSID3048659 TK.Half.Life NA 3.972 hours 1compartment NA NA Human Human +DTXSID3048659 Css NA 0.08752 mg/L 3compartmentss NA 50% Human Human +DTXSID3048659 Css NA 0.76 mg/L 3compartmentss NA 95% Human Human +DTXSID3048659 Css NA 0.1006 mg/L PBTK NA 50% Human Human +DTXSID3048659 Css NA 0.6347 mg/L PBTK NA 95% Human Human +DTXSID3048659 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048659 Fup 0.463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048659 Vd NA 2.577 L/kg 1compartment NA NA Rat Human DTXSID3048659 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048659 TK.Half.Life NA 3.334 hours 1compartment NA NA Rat Human -DTXSID3048659 Css NA 0.06578 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048659 Css NA 0.3889 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048659 Css NA 0.07485 mg/L PBTK NA 50% Rat Human -DTXSID3048659 Css NA 0.3081 mg/L PBTK NA 95% Rat Human -DTXSID3048730 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3048659 TK.Half.Life NA 2.273 hours 1compartment NA NA Rat Human +DTXSID3048659 Css NA 0.009805 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048659 Css NA 0.06939 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048659 Css NA 0.01155 mg/L PBTK NA 50% Rat Human +DTXSID3048659 Css NA 0.05532 mg/L PBTK NA 95% Rat Human +DTXSID3048730 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3048730 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3048730 Vd NA 2.925 L/kg 1compartment NA NA Human Human -DTXSID3048730 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID3048730 TK.Half.Life NA 66.2 hours 1compartment NA NA Human Human -DTXSID3048730 Css NA 2.786 mg/L 3compartmentss NA 50% Human Human -DTXSID3048730 Css NA 15.18 mg/L 3compartmentss NA 95% Human Human -DTXSID3048730 Css NA 1.971 mg/L PBTK NA 50% Human Human -DTXSID3048730 Css NA 10.2 mg/L PBTK NA 95% Human Human -DTXSID3048730 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3048730 Vd NA 0.5835 L/kg 1compartment NA NA Human Human +DTXSID3048730 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048730 TK.Half.Life NA 1.255 hours 1compartment NA NA Human Human +DTXSID3048730 Css NA 0.2041 mg/L 3compartmentss NA 50% Human Human +DTXSID3048730 Css NA 1.711 mg/L 3compartmentss NA 95% Human Human +DTXSID3048730 Css NA 0.1318 mg/L PBTK NA 50% Human Human +DTXSID3048730 Css NA 1.044 mg/L PBTK NA 95% Human Human +DTXSID3048730 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3048730 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3048730 Vd NA 2.214 L/kg 1compartment NA NA Rat Human -DTXSID3048730 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID3048730 TK.Half.Life NA 11.58 hours 1compartment NA NA Rat Human -DTXSID3048730 Css NA 1.475 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048730 Css NA 5.572 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048730 Css NA 0.9972 mg/L PBTK NA 50% Rat Human -DTXSID3048730 Css NA 3.644 mg/L PBTK NA 95% Rat Human -DTXSID3048732 Clint NA 0.6141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048732 Fup NA 0.1583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048732 Vd NA 0.3545 L/kg 1compartment NA NA Human Human -DTXSID3048732 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048732 TK.Half.Life NA 7.151 hours 1compartment NA NA Human Human -DTXSID3048732 Css NA 2.724 mg/L 3compartmentss NA 50% Human Human -DTXSID3048732 Css NA 12.65 mg/L 3compartmentss NA 95% Human Human -DTXSID3048732 Css NA 1.756 mg/L PBTK NA 50% Human Human -DTXSID3048732 Css NA 7.639 mg/L PBTK NA 95% Human Human -DTXSID3048732 Clint NA 0.6141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048732 Fup NA 0.1583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048732 Vd NA 0.3583 L/kg 1compartment NA NA Rat Human +DTXSID3048730 Vd NA 0.5322 L/kg 1compartment NA NA Rat Human +DTXSID3048730 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048730 TK.Half.Life NA 0.6583 hours 1compartment NA NA Rat Human +DTXSID3048730 Css NA 0.02644 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048730 Css NA 0.1708 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048730 Css NA 0.01669 mg/L PBTK NA 50% Rat Human +DTXSID3048730 Css NA 0.1011 mg/L PBTK NA 95% Rat Human +DTXSID3048732 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048732 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048732 Vd NA 0.4822 L/kg 1compartment NA NA Human Human +DTXSID3048732 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3048732 TK.Half.Life NA 10.03 hours 1compartment NA NA Human Human +DTXSID3048732 Css NA 1.276 mg/L 3compartmentss NA 50% Human Human +DTXSID3048732 Css NA 5.468 mg/L 3compartmentss NA 95% Human Human +DTXSID3048732 Css NA 0.9132 mg/L PBTK NA 50% Human Human +DTXSID3048732 Css NA 3.48 mg/L PBTK NA 95% Human Human +DTXSID3048732 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048732 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048732 Vd NA 0.4916 L/kg 1compartment NA NA Rat Human DTXSID3048732 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048732 TK.Half.Life NA 3.321 hours 1compartment NA NA Rat Human -DTXSID3048732 Css NA 1.055 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048732 Css NA 3.996 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048732 Css NA 0.6383 mg/L PBTK NA 50% Rat Human -DTXSID3048732 Css NA 2.231 mg/L PBTK NA 95% Rat Human -DTXSID3048734 Clint NA 381.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048734 Fup NA 0.0157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048734 Vd NA 3.071 L/kg 1compartment NA NA Human Human -DTXSID3048734 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048734 TK.Half.Life NA 6.665 hours 1compartment NA NA Human Human -DTXSID3048734 Css NA 0.1739 mg/L 3compartmentss NA 50% Human Human -DTXSID3048734 Css NA 1.112 mg/L 3compartmentss NA 95% Human Human -DTXSID3048734 Css NA 0.1207 mg/L PBTK NA 50% Human Human -DTXSID3048734 Css NA 0.7321 mg/L PBTK NA 95% Human Human -DTXSID3048734 Clint NA 381.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048734 Fup NA 0.0157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048734 Vd NA 2.305 L/kg 1compartment NA NA Rat Human -DTXSID3048734 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048734 TK.Half.Life NA 1.415 hours 1compartment NA NA Rat Human -DTXSID3048734 Css NA 0.09732 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048734 Css NA 0.525 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048734 Css NA 0.06456 mg/L PBTK NA 50% Rat Human -DTXSID3048734 Css NA 0.3316 mg/L PBTK NA 95% Rat Human -DTXSID3048736 Clint NA 41.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048736 Fup NA 0.0326 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048736 Vd NA 1.623 L/kg 1compartment NA NA Human Human +DTXSID3048732 TK.Half.Life NA 3.485 hours 1compartment NA NA Rat Human +DTXSID3048732 Css NA 0.006923 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048732 Css NA 0.02975 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048732 Css NA 0.004707 mg/L PBTK NA 50% Rat Human +DTXSID3048732 Css NA 0.01827 mg/L PBTK NA 95% Rat Human +DTXSID3048734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048734 Fup 0.0545 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048734 Vd NA 3.715 L/kg 1compartment NA NA Human Human +DTXSID3048734 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID3048734 TK.Half.Life NA 107.2 hours 1compartment NA NA Human Human +DTXSID3048734 Css NA 3.154 mg/L 3compartmentss NA 50% Human Human +DTXSID3048734 Css NA 19.49 mg/L 3compartmentss NA 95% Human Human +DTXSID3048734 Css NA 2.315 mg/L PBTK NA 50% Human Human +DTXSID3048734 Css NA 13.87 mg/L PBTK NA 95% Human Human +DTXSID3048734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048734 Fup 0.0545 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048734 Vd NA 2.805 L/kg 1compartment NA NA Rat Human +DTXSID3048734 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID3048734 TK.Half.Life NA 14.27 hours 1compartment NA NA Rat Human +DTXSID3048734 Css NA 0.4104 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048734 Css NA 2.199 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048734 Css NA 0.2995 mg/L PBTK NA 50% Rat Human +DTXSID3048734 Css NA 1.589 mg/L PBTK NA 95% Rat Human +DTXSID3048736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048736 Fup 0.0311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048736 Vd NA 1.592 L/kg 1compartment NA NA Human Human DTXSID3048736 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048736 TK.Half.Life NA 6.296 hours 1compartment NA NA Human Human -DTXSID3048736 Css NA 0.5185 mg/L 3compartmentss NA 50% Human Human -DTXSID3048736 Css NA 4.227 mg/L 3compartmentss NA 95% Human Human -DTXSID3048736 Css NA 0.33 mg/L PBTK NA 50% Human Human -DTXSID3048736 Css NA 2.611 mg/L PBTK NA 95% Human Human -DTXSID3048736 Clint NA 41.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048736 Fup NA 0.0326 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048736 Vd NA 1.211 L/kg 1compartment NA NA Rat Human +DTXSID3048736 TK.Half.Life NA 10.81 hours 1compartment NA NA Human Human +DTXSID3048736 Css NA 0.9997 mg/L 3compartmentss NA 50% Human Human +DTXSID3048736 Css NA 8.691 mg/L 3compartmentss NA 95% Human Human +DTXSID3048736 Css NA 0.6374 mg/L PBTK NA 50% Human Human +DTXSID3048736 Css NA 5.28 mg/L PBTK NA 95% Human Human +DTXSID3048736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048736 Fup 0.0311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048736 Vd NA 1.187 L/kg 1compartment NA NA Rat Human DTXSID3048736 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048736 TK.Half.Life NA 2.324 hours 1compartment NA NA Rat Human -DTXSID3048736 Css NA 0.2948 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048736 Css NA 2.023 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048736 Css NA 0.1761 mg/L PBTK NA 50% Rat Human -DTXSID3048736 Css NA 1.146 mg/L PBTK NA 95% Rat Human -DTXSID3048738 Clint NA 0.1594 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048738 Fup NA 0.882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048738 Vd NA 1.035 L/kg 1compartment NA NA Human Human -DTXSID3048738 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048738 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human -DTXSID3048738 Css NA 0.6991 mg/L 3compartmentss NA 50% Human Human -DTXSID3048738 Css NA 4.078 mg/L 3compartmentss NA 95% Human Human -DTXSID3048738 Css NA 0.6005 mg/L PBTK NA 50% Human Human -DTXSID3048738 Css NA 2.677 mg/L PBTK NA 95% Human Human -DTXSID3048738 Clint NA 0.1594 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048738 Fup NA 0.882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048738 Vd NA 1.039 L/kg 1compartment NA NA Rat Human -DTXSID3048738 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048738 TK.Half.Life NA 2.306 hours 1compartment NA NA Rat Human -DTXSID3048738 Css NA 0.2024 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048738 Css NA 1.184 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048738 Css NA 0.169 mg/L PBTK NA 50% Rat Human -DTXSID3048738 Css NA 0.7227 mg/L PBTK NA 95% Rat Human -DTXSID3048780 Clint NA 76.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3048736 TK.Half.Life NA 4.051 hours 1compartment NA NA Rat Human +DTXSID3048736 Css NA 0.132 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048736 Css NA 0.8565 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048736 Css NA 0.08133 mg/L PBTK NA 50% Rat Human +DTXSID3048736 Css NA 0.5057 mg/L PBTK NA 95% Rat Human +DTXSID3048780 Clint 22 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID3048780 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3048780 Vd NA 0.6976 L/kg 1compartment NA NA Human Human -DTXSID3048780 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048780 TK.Half.Life NA 3.603 hours 1compartment NA NA Human Human -DTXSID3048780 Css NA 0.7997 mg/L 3compartmentss NA 50% Human Human -DTXSID3048780 Css NA 8.264 mg/L 3compartmentss NA 95% Human Human -DTXSID3048780 Css NA 0.4739 mg/L PBTK NA 50% Human Human -DTXSID3048780 Css NA 4.792 mg/L PBTK NA 95% Human Human -DTXSID3048780 Clint NA 76.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3048780 Vd NA 2.411 L/kg 1compartment NA NA Human Human +DTXSID3048780 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID3048780 TK.Half.Life NA 40.85 hours 1compartment NA NA Human Human +DTXSID3048780 Css NA 2.431 mg/L 3compartmentss NA 50% Human Human +DTXSID3048780 Css NA 18.71 mg/L 3compartmentss NA 95% Human Human +DTXSID3048780 Css NA 1.592 mg/L PBTK NA 50% Human Human +DTXSID3048780 Css NA 11.82 mg/L PBTK NA 95% Human Human +DTXSID3048780 Clint 22 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID3048780 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3048780 Vd NA 0.5191 L/kg 1compartment NA NA Rat Human -DTXSID3048780 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048780 TK.Half.Life NA 1.647 hours 1compartment NA NA Rat Human -DTXSID3048780 Css NA 0.4655 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048780 Css NA 3.872 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048780 Css NA 0.2588 mg/L PBTK NA 50% Rat Human -DTXSID3048780 Css NA 2.133 mg/L PBTK NA 95% Rat Human +DTXSID3048780 Vd NA 1.794 L/kg 1compartment NA NA Rat Human +DTXSID3048780 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID3048780 TK.Half.Life NA 10.58 hours 1compartment NA NA Rat Human +DTXSID3048780 Css NA 0.3169 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048780 Css NA 2.087 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048780 Css NA 0.2041 mg/L PBTK NA 50% Rat Human +DTXSID3048780 Css NA 1.279 mg/L PBTK NA 95% Rat Human DTXSID3048782 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3048782 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048782 Vd NA 0.2132 L/kg 1compartment NA NA Human Human +DTXSID3048782 Vd NA 0.2204 L/kg 1compartment NA NA Human Human DTXSID3048782 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID3048782 TK.Half.Life NA 66.97 hours 1compartment NA NA Human Human -DTXSID3048782 Css NA 53.69 mg/L 3compartmentss NA 50% Human Human -DTXSID3048782 Css NA 310.9 mg/L 3compartmentss NA 95% Human Human -DTXSID3048782 Css NA 31.64 mg/L PBTK NA 50% Human Human -DTXSID3048782 Css NA 180.8 mg/L PBTK NA 95% Human Human +DTXSID3048782 TK.Half.Life NA 69.25 hours 1compartment NA NA Human Human +DTXSID3048782 Css NA 44.94 mg/L 3compartmentss NA 50% Human Human +DTXSID3048782 Css NA 279.1 mg/L 3compartmentss NA 95% Human Human +DTXSID3048782 Css NA 26.56 mg/L PBTK NA 50% Human Human +DTXSID3048782 Css NA 161.7 mg/L PBTK NA 95% Human Human DTXSID3048782 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3048782 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048782 Vd NA 0.2099 L/kg 1compartment NA NA Rat Human +DTXSID3048782 Vd NA 0.2164 L/kg 1compartment NA NA Rat Human DTXSID3048782 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3048782 TK.Half.Life NA 22.47 hours 1compartment NA NA Rat Human -DTXSID3048782 Css NA 15.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048782 Css NA 80.58 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048782 Css NA 8.456 mg/L PBTK NA 50% Rat Human -DTXSID3048782 Css NA 43.68 mg/L PBTK NA 95% Rat Human -DTXSID3048788 Clint NA 6.691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048788 Fup NA 0.389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048788 Vd NA 0.3339 L/kg 1compartment NA NA Human Human +DTXSID3048782 TK.Half.Life NA 23.16 hours 1compartment NA NA Rat Human +DTXSID3048782 Css NA 0.8738 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048782 Css NA 7.279 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048782 Css NA 0.4912 mg/L PBTK NA 50% Rat Human +DTXSID3048782 Css NA 4.037 mg/L PBTK NA 95% Rat Human +DTXSID3048786 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048786 Fup 0.0614 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048786 Vd NA 1.739 L/kg 1compartment NA NA Human Human +DTXSID3048786 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID3048786 TK.Half.Life NA 21.26 hours 1compartment NA NA Human Human +DTXSID3048786 Css NA 1.834 mg/L 3compartmentss NA 50% Human Human +DTXSID3048786 Css NA 11.58 mg/L 3compartmentss NA 95% Human Human +DTXSID3048786 Css NA 1.188 mg/L PBTK NA 50% Human Human +DTXSID3048786 Css NA 7.142 mg/L PBTK NA 95% Human Human +DTXSID3048786 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048786 Fup 0.0614 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048786 Vd NA 1.308 L/kg 1compartment NA NA Rat Human +DTXSID3048786 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3048786 TK.Half.Life NA 7.395 hours 1compartment NA NA Rat Human +DTXSID3048786 Css NA 0.2235 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048786 Css NA 1.065 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048786 Css NA 0.1426 mg/L PBTK NA 50% Rat Human +DTXSID3048786 Css NA 0.6409 mg/L PBTK NA 95% Rat Human +DTXSID3048788 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048788 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048788 Vd NA 0.3364 L/kg 1compartment NA NA Human Human DTXSID3048788 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048788 TK.Half.Life NA 0.6665 hours 1compartment NA NA Human Human -DTXSID3048788 Css NA 0.1706 mg/L 3compartmentss NA 50% Human Human -DTXSID3048788 Css NA 1.11 mg/L 3compartmentss NA 95% Human Human -DTXSID3048788 Css NA 0.1146 mg/L PBTK NA 50% Human Human -DTXSID3048788 Css NA 0.6939 mg/L PBTK NA 95% Human Human -DTXSID3048788 Clint NA 6.691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048788 Fup NA 0.389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048788 Vd NA 0.3449 L/kg 1compartment NA NA Rat Human +DTXSID3048788 TK.Half.Life NA 5.108 hours 1compartment NA NA Human Human +DTXSID3048788 Css NA 0.9932 mg/L 3compartmentss NA 50% Human Human +DTXSID3048788 Css NA 4.619 mg/L 3compartmentss NA 95% Human Human +DTXSID3048788 Css NA 0.6756 mg/L PBTK NA 50% Human Human +DTXSID3048788 Css NA 2.85 mg/L PBTK NA 95% Human Human +DTXSID3048788 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048788 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048788 Vd NA 0.3498 L/kg 1compartment NA NA Rat Human DTXSID3048788 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048788 TK.Half.Life NA 0.3804 hours 1compartment NA NA Rat Human -DTXSID3048788 Css NA 0.08778 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048788 Css NA 0.4137 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048788 Css NA 0.05602 mg/L PBTK NA 50% Rat Human -DTXSID3048788 Css NA 0.2433 mg/L PBTK NA 95% Rat Human -DTXSID3048811 Clint NA 84.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048811 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048811 Vd NA 3.008 L/kg 1compartment NA NA Human Human -DTXSID3048811 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3048811 TK.Half.Life NA 19.32 hours 1compartment NA NA Human Human -DTXSID3048811 Css NA 0.7436 mg/L 3compartmentss NA 50% Human Human -DTXSID3048811 Css NA 4.694 mg/L 3compartmentss NA 95% Human Human -DTXSID3048811 Css NA 0.5131 mg/L PBTK NA 50% Human Human -DTXSID3048811 Css NA 3.125 mg/L PBTK NA 95% Human Human -DTXSID3048811 Clint NA 84.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048811 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048811 Vd NA 2.252 L/kg 1compartment NA NA Rat Human -DTXSID3048811 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3048811 TK.Half.Life NA 3.358 hours 1compartment NA NA Rat Human -DTXSID3048811 Css NA 0.4204 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048811 Css NA 2.209 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048811 Css NA 0.2756 mg/L PBTK NA 50% Rat Human -DTXSID3048811 Css NA 1.411 mg/L PBTK NA 95% Rat Human -DTXSID3048813 Clint NA 231.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048813 Fup NA 0.2413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048813 Vd NA 0.7397 L/kg 1compartment NA NA Human Human +DTXSID3048788 TK.Half.Life NA 1.811 hours 1compartment NA NA Rat Human +DTXSID3048788 Css NA 0.005378 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048788 Css NA 0.0252 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048788 Css NA 0.003476 mg/L PBTK NA 50% Rat Human +DTXSID3048788 Css NA 0.01467 mg/L PBTK NA 95% Rat Human +DTXSID3048811 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048811 Fup 0.0173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048811 Vd NA 3.047 L/kg 1compartment NA NA Human Human +DTXSID3048811 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID3048811 TK.Half.Life NA 70.95 hours 1compartment NA NA Human Human +DTXSID3048811 Css NA 2.838 mg/L 3compartmentss NA 50% Human Human +DTXSID3048811 Css NA 19.15 mg/L 3compartmentss NA 95% Human Human +DTXSID3048811 Css NA 1.953 mg/L PBTK NA 50% Human Human +DTXSID3048811 Css NA 12.66 mg/L PBTK NA 95% Human Human +DTXSID3048811 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048811 Fup 0.0173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048811 Vd NA 2.282 L/kg 1compartment NA NA Rat Human +DTXSID3048811 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID3048811 TK.Half.Life NA 10.63 hours 1compartment NA NA Rat Human +DTXSID3048811 Css NA 0.37 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048811 Css NA 2.102 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048811 Css NA 0.252 mg/L PBTK NA 50% Rat Human +DTXSID3048811 Css NA 1.415 mg/L PBTK NA 95% Rat Human +DTXSID3048813 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048813 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048813 Vd NA 0.762 L/kg 1compartment NA NA Human Human DTXSID3048813 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048813 TK.Half.Life NA 0.6279 hours 1compartment NA NA Human Human -DTXSID3048813 Css NA 0.008806 mg/L 3compartmentss NA 50% Human Human -DTXSID3048813 Css NA 0.06917 mg/L 3compartmentss NA 95% Human Human -DTXSID3048813 Css NA 0.006207 mg/L PBTK NA 50% Human Human -DTXSID3048813 Css NA 0.04608 mg/L PBTK NA 95% Human Human -DTXSID3048813 Clint NA 231.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048813 Fup NA 0.2413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048813 Vd NA 0.6684 L/kg 1compartment NA NA Rat Human +DTXSID3048813 TK.Half.Life NA 2.481 hours 1compartment NA NA Human Human +DTXSID3048813 Css NA 0.3169 mg/L 3compartmentss NA 50% Human Human +DTXSID3048813 Css NA 1.788 mg/L 3compartmentss NA 95% Human Human +DTXSID3048813 Css NA 0.2205 mg/L PBTK NA 50% Human Human +DTXSID3048813 Css NA 1.167 mg/L PBTK NA 95% Human Human +DTXSID3048813 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048813 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048813 Vd NA 0.6778 L/kg 1compartment NA NA Rat Human DTXSID3048813 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048813 TK.Half.Life NA 0.2571 hours 1compartment NA NA Rat Human -DTXSID3048813 Css NA 0.004894 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048813 Css NA 0.02993 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048813 Css NA 0.003286 mg/L PBTK NA 50% Rat Human -DTXSID3048813 Css NA 0.01876 mg/L PBTK NA 95% Rat Human -DTXSID3048815 Clint NA 34.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048815 Fup NA 0.0567 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048815 Vd NA 0.3146 L/kg 1compartment NA NA Human Human +DTXSID3048813 TK.Half.Life NA 1.264 hours 1compartment NA NA Rat Human +DTXSID3048813 Css NA 0.03686 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048813 Css NA 0.1616 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048813 Css NA 0.02556 mg/L PBTK NA 50% Rat Human +DTXSID3048813 Css NA 0.1026 mg/L PBTK NA 95% Rat Human +DTXSID3048815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048815 Fup 0.0837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048815 Vd NA 0.3688 L/kg 1compartment NA NA Human Human DTXSID3048815 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048815 TK.Half.Life NA 0.8879 hours 1compartment NA NA Human Human -DTXSID3048815 Css NA 0.3513 mg/L 3compartmentss NA 50% Human Human -DTXSID3048815 Css NA 2.822 mg/L 3compartmentss NA 95% Human Human -DTXSID3048815 Css NA 0.2116 mg/L PBTK NA 50% Human Human -DTXSID3048815 Css NA 1.673 mg/L PBTK NA 95% Human Human -DTXSID3048815 Clint NA 34.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048815 Fup NA 0.0567 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048815 Vd NA 0.2843 L/kg 1compartment NA NA Rat Human +DTXSID3048815 TK.Half.Life NA 1.078 hours 1compartment NA NA Human Human +DTXSID3048815 Css NA 0.3037 mg/L 3compartmentss NA 50% Human Human +DTXSID3048815 Css NA 2.411 mg/L 3compartmentss NA 95% Human Human +DTXSID3048815 Css NA 0.1874 mg/L PBTK NA 50% Human Human +DTXSID3048815 Css NA 1.466 mg/L PBTK NA 95% Human Human +DTXSID3048815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048815 Fup 0.0837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048815 Vd NA 0.3318 L/kg 1compartment NA NA Rat Human DTXSID3048815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048815 TK.Half.Life NA 0.4834 hours 1compartment NA NA Rat Human -DTXSID3048815 Css NA 0.201 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048815 Css NA 1.282 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048815 Css NA 0.1137 mg/L PBTK NA 50% Rat Human -DTXSID3048815 Css NA 0.7125 mg/L PBTK NA 95% Rat Human -DTXSID3048817 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048817 Fup NA 0.828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048817 Vd NA 0.4328 L/kg 1compartment NA NA Human Human +DTXSID3048815 TK.Half.Life NA 0.5825 hours 1compartment NA NA Rat Human +DTXSID3048815 Css NA 0.0149 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048815 Css NA 0.1272 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048815 Css NA 0.008902 mg/L PBTK NA 50% Rat Human +DTXSID3048815 Css NA 0.07305 mg/L PBTK NA 95% Rat Human +DTXSID3048817 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048817 Fup 0.747 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048817 Vd NA 0.4108 L/kg 1compartment NA NA Human Human DTXSID3048817 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048817 TK.Half.Life NA 3.381 hours 1compartment NA NA Human Human -DTXSID3048817 Css NA 1.098 mg/L 3compartmentss NA 50% Human Human -DTXSID3048817 Css NA 6.026 mg/L 3compartmentss NA 95% Human Human -DTXSID3048817 Css NA 0.7988 mg/L PBTK NA 50% Human Human -DTXSID3048817 Css NA 3.729 mg/L PBTK NA 95% Human Human -DTXSID3048817 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048817 Fup NA 0.828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048817 Vd NA 0.4574 L/kg 1compartment NA NA Rat Human +DTXSID3048817 TK.Half.Life NA 3.558 hours 1compartment NA NA Human Human +DTXSID3048817 Css NA 1.011 mg/L 3compartmentss NA 50% Human Human +DTXSID3048817 Css NA 6.006 mg/L 3compartmentss NA 95% Human Human +DTXSID3048817 Css NA 0.733 mg/L PBTK NA 50% Human Human +DTXSID3048817 Css NA 3.676 mg/L PBTK NA 95% Human Human +DTXSID3048817 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048817 Fup 0.747 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048817 Vd NA 0.4336 L/kg 1compartment NA NA Rat Human DTXSID3048817 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048817 TK.Half.Life NA 1.218 hours 1compartment NA NA Rat Human -DTXSID3048817 Css NA 0.2848 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048817 Css NA 1.492 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048817 Css NA 0.1987 mg/L PBTK NA 50% Rat Human -DTXSID3048817 Css NA 0.8602 mg/L PBTK NA 95% Rat Human -DTXSID3048819 Clint NA 0.04978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048819 Fup NA 0.2876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048819 Vd NA 0.5099 L/kg 1compartment NA NA Human Human +DTXSID3048817 TK.Half.Life NA 1.28 hours 1compartment NA NA Rat Human +DTXSID3048817 Css NA 0.02634 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048817 Css NA 0.1807 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048817 Css NA 0.01814 mg/L PBTK NA 50% Rat Human +DTXSID3048817 Css NA 0.1086 mg/L PBTK NA 95% Rat Human +DTXSID3048819 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048819 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048819 Vd NA 0.427 L/kg 1compartment NA NA Human Human DTXSID3048819 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3048819 TK.Half.Life NA 10.71 hours 1compartment NA NA Human Human -DTXSID3048819 Css NA 2.475 mg/L 3compartmentss NA 50% Human Human -DTXSID3048819 Css NA 9.626 mg/L 3compartmentss NA 95% Human Human -DTXSID3048819 Css NA 1.711 mg/L PBTK NA 50% Human Human -DTXSID3048819 Css NA 6.005 mg/L PBTK NA 95% Human Human -DTXSID3048819 Clint NA 0.04978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048819 Fup NA 0.2876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048819 Vd NA 0.4796 L/kg 1compartment NA NA Rat Human +DTXSID3048819 TK.Half.Life NA 13.65 hours 1compartment NA NA Human Human +DTXSID3048819 Css NA 3.806 mg/L 3compartmentss NA 50% Human Human +DTXSID3048819 Css NA 13.8 mg/L 3compartmentss NA 95% Human Human +DTXSID3048819 Css NA 2.515 mg/L PBTK NA 50% Human Human +DTXSID3048819 Css NA 8.432 mg/L PBTK NA 95% Human Human +DTXSID3048819 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048819 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048819 Vd NA 0.4015 L/kg 1compartment NA NA Rat Human DTXSID3048819 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048819 TK.Half.Life NA 3.544 hours 1compartment NA NA Rat Human -DTXSID3048819 Css NA 0.7158 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048819 Css NA 2.373 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048819 Css NA 0.4676 mg/L PBTK NA 50% Rat Human -DTXSID3048819 Css NA 1.374 mg/L PBTK NA 95% Rat Human +DTXSID3048819 TK.Half.Life NA 4.348 hours 1compartment NA NA Rat Human +DTXSID3048819 Css NA 0.2476 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048819 Css NA 0.756 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048819 Css NA 0.159 mg/L PBTK NA 50% Rat Human +DTXSID3048819 Css NA 0.4452 mg/L PBTK NA 95% Rat Human DTXSID3048861 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3048861 Fup NA 0.5888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048861 Vd NA 0.3852 L/kg 1compartment NA NA Human Human +DTXSID3048861 Vd NA 0.3873 L/kg 1compartment NA NA Human Human DTXSID3048861 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048861 TK.Half.Life NA 4.232 hours 1compartment NA NA Human Human -DTXSID3048861 Css NA 1.388 mg/L 3compartmentss NA 50% Human Human -DTXSID3048861 Css NA 9.105 mg/L 3compartmentss NA 95% Human Human -DTXSID3048861 Css NA 0.9936 mg/L PBTK NA 50% Human Human -DTXSID3048861 Css NA 5.498 mg/L PBTK NA 95% Human Human +DTXSID3048861 TK.Half.Life NA 4.255 hours 1compartment NA NA Human Human +DTXSID3048861 Css NA 1.178 mg/L 3compartmentss NA 50% Human Human +DTXSID3048861 Css NA 7.599 mg/L 3compartmentss NA 95% Human Human +DTXSID3048861 Css NA 0.8458 mg/L PBTK NA 50% Human Human +DTXSID3048861 Css NA 4.662 mg/L PBTK NA 95% Human Human DTXSID3048861 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3048861 Fup NA 0.5888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048861 Vd NA 0.413 L/kg 1compartment NA NA Rat Human +DTXSID3048861 Vd NA 0.4147 L/kg 1compartment NA NA Rat Human DTXSID3048861 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048861 TK.Half.Life NA 1.547 hours 1compartment NA NA Rat Human -DTXSID3048861 Css NA 0.3734 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048861 Css NA 2.163 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048861 Css NA 0.2539 mg/L PBTK NA 50% Rat Human -DTXSID3048861 Css NA 1.231 mg/L PBTK NA 95% Rat Human -DTXSID3048863 Clint NA 10.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048863 Fup NA 0.084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048863 Vd NA 1.934 L/kg 1compartment NA NA Human Human -DTXSID3048863 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3048863 TK.Half.Life NA 12.91 hours 1compartment NA NA Human Human -DTXSID3048863 Css NA 0.9008 mg/L 3compartmentss NA 50% Human Human -DTXSID3048863 Css NA 5.918 mg/L 3compartmentss NA 95% Human Human -DTXSID3048863 Css NA 0.601 mg/L PBTK NA 50% Human Human -DTXSID3048863 Css NA 3.781 mg/L PBTK NA 95% Human Human -DTXSID3048863 Clint NA 10.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048863 Fup NA 0.084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048863 Vd NA 1.461 L/kg 1compartment NA NA Rat Human +DTXSID3048861 TK.Half.Life NA 1.553 hours 1compartment NA NA Rat Human +DTXSID3048861 Css NA 0.02306 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048861 Css NA 0.1735 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048861 Css NA 0.01593 mg/L PBTK NA 50% Rat Human +DTXSID3048861 Css NA 0.1046 mg/L PBTK NA 95% Rat Human +DTXSID3048863 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048863 Fup 0.0776 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048863 Vd NA 1.75 L/kg 1compartment NA NA Human Human +DTXSID3048863 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048863 TK.Half.Life NA 6.365 hours 1compartment NA NA Human Human +DTXSID3048863 Css NA 0.4295 mg/L 3compartmentss NA 50% Human Human +DTXSID3048863 Css NA 3.015 mg/L 3compartmentss NA 95% Human Human +DTXSID3048863 Css NA 0.2835 mg/L PBTK NA 50% Human Human +DTXSID3048863 Css NA 1.899 mg/L PBTK NA 95% Human Human +DTXSID3048863 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048863 Fup 0.0776 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048863 Vd NA 1.323 L/kg 1compartment NA NA Rat Human DTXSID3048863 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048863 TK.Half.Life NA 4.297 hours 1compartment NA NA Rat Human -DTXSID3048863 Css NA 0.4882 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048863 Css NA 2.342 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048863 Css NA 0.31 mg/L PBTK NA 50% Rat Human -DTXSID3048863 Css NA 1.404 mg/L PBTK NA 95% Rat Human -DTXSID3048865 Clint NA 14.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048865 Fup NA 0.6218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048865 Vd NA 3.583 L/kg 1compartment NA NA Human Human +DTXSID3048863 TK.Half.Life NA 2.288 hours 1compartment NA NA Rat Human +DTXSID3048863 Css NA 0.0554 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048863 Css NA 0.3122 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048863 Css NA 0.0359 mg/L PBTK NA 50% Rat Human +DTXSID3048863 Css NA 0.1938 mg/L PBTK NA 95% Rat Human +DTXSID3048865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048865 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048865 Vd NA 3.497 L/kg 1compartment NA NA Human Human DTXSID3048865 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048865 TK.Half.Life NA 2.636 hours 1compartment NA NA Human Human -DTXSID3048865 Css NA 0.03026 mg/L 3compartmentss NA 50% Human Human -DTXSID3048865 Css NA 0.372 mg/L 3compartmentss NA 95% Human Human -DTXSID3048865 Css NA 0.03996 mg/L PBTK NA 50% Human Human -DTXSID3048865 Css NA 0.3258 mg/L PBTK NA 95% Human Human -DTXSID3048865 Clint NA 14.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048865 Fup NA 0.6218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048865 Vd NA 3.6 L/kg 1compartment NA NA Rat Human +DTXSID3048865 TK.Half.Life NA 2.407 hours 1compartment NA NA Human Human +DTXSID3048865 Css NA 0.02053 mg/L 3compartmentss NA 50% Human Human +DTXSID3048865 Css NA 0.243 mg/L 3compartmentss NA 95% Human Human +DTXSID3048865 Css NA 0.02692 mg/L PBTK NA 50% Human Human +DTXSID3048865 Css NA 0.2252 mg/L PBTK NA 95% Human Human +DTXSID3048865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048865 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048865 Vd NA 3.511 L/kg 1compartment NA NA Rat Human DTXSID3048865 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048865 TK.Half.Life NA 1.449 hours 1compartment NA NA Rat Human -DTXSID3048865 Css NA 0.01476 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048865 Css NA 0.1662 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048865 Css NA 0.01995 mg/L PBTK NA 50% Rat Human -DTXSID3048865 Css NA 0.1352 mg/L PBTK NA 95% Rat Human -DTXSID3048867 Clint NA 2.757 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048867 Fup NA 0.9863 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048867 Vd NA 2.87 L/kg 1compartment NA NA Human Human +DTXSID3048865 TK.Half.Life NA 1.298 hours 1compartment NA NA Rat Human +DTXSID3048865 Css NA 0.002468 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048865 Css NA 0.02374 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048865 Css NA 0.0034 mg/L PBTK NA 50% Rat Human +DTXSID3048865 Css NA 0.02128 mg/L PBTK NA 95% Rat Human +DTXSID3048867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048867 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048867 Vd NA 2 L/kg 1compartment NA NA Human Human DTXSID3048867 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048867 TK.Half.Life NA 7.774 hours 1compartment NA NA Human Human -DTXSID3048867 Css NA 0.2195 mg/L 3compartmentss NA 50% Human Human -DTXSID3048867 Css NA 1.519 mg/L 3compartmentss NA 95% Human Human -DTXSID3048867 Css NA 0.2145 mg/L PBTK NA 50% Human Human -DTXSID3048867 Css NA 1.17 mg/L PBTK NA 95% Human Human -DTXSID3048867 Clint NA 2.757 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048867 Fup NA 0.9863 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048867 Vd NA 2.416 L/kg 1compartment NA NA Rat Human +DTXSID3048867 TK.Half.Life NA 2.759 hours 1compartment NA NA Human Human +DTXSID3048867 Css NA 0.07789 mg/L 3compartmentss NA 50% Human Human +DTXSID3048867 Css NA 0.5217 mg/L 3compartmentss NA 95% Human Human +DTXSID3048867 Css NA 0.06162 mg/L PBTK NA 50% Human Human +DTXSID3048867 Css NA 0.3816 mg/L PBTK NA 95% Human Human +DTXSID3048867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048867 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048867 Vd NA 1.641 L/kg 1compartment NA NA Rat Human DTXSID3048867 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048867 TK.Half.Life NA 2.279 hours 1compartment NA NA Rat Human -DTXSID3048867 Css NA 0.09918 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048867 Css NA 0.526 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048867 Css NA 0.09582 mg/L PBTK NA 50% Rat Human -DTXSID3048867 Css NA 0.3762 mg/L PBTK NA 95% Rat Human -DTXSID3048869 Clint NA 22.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048869 Fup NA 0.4021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048869 Vd NA 3.464 L/kg 1compartment NA NA Human Human +DTXSID3048867 TK.Half.Life NA 1.049 hours 1compartment NA NA Rat Human +DTXSID3048867 Css NA 0.009621 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048867 Css NA 0.05146 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048867 Css NA 0.007656 mg/L PBTK NA 50% Rat Human +DTXSID3048867 Css NA 0.03748 mg/L PBTK NA 95% Rat Human +DTXSID3048869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048869 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048869 Vd NA 1.849 L/kg 1compartment NA NA Human Human DTXSID3048869 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048869 TK.Half.Life NA 3.07 hours 1compartment NA NA Human Human -DTXSID3048869 Css NA 0.03525 mg/L 3compartmentss NA 50% Human Human -DTXSID3048869 Css NA 0.3026 mg/L 3compartmentss NA 95% Human Human -DTXSID3048869 Css NA 0.03996 mg/L PBTK NA 50% Human Human -DTXSID3048869 Css NA 0.2737 mg/L PBTK NA 95% Human Human -DTXSID3048869 Clint NA 22.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048869 Fup NA 0.4021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048869 Vd NA 3.412 L/kg 1compartment NA NA Rat Human +DTXSID3048869 TK.Half.Life NA 2.776 hours 1compartment NA NA Human Human +DTXSID3048869 Css NA 0.0911 mg/L 3compartmentss NA 50% Human Human +DTXSID3048869 Css NA 0.6162 mg/L 3compartmentss NA 95% Human Human +DTXSID3048869 Css NA 0.069 mg/L PBTK NA 50% Human Human +DTXSID3048869 Css NA 0.4451 mg/L PBTK NA 95% Human Human +DTXSID3048869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048869 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048869 Vd NA 1.46 L/kg 1compartment NA NA Rat Human DTXSID3048869 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048869 TK.Half.Life NA 1.549 hours 1compartment NA NA Rat Human -DTXSID3048869 Css NA 0.01818 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048869 Css NA 0.1284 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048869 Css NA 0.02049 mg/L PBTK NA 50% Rat Human -DTXSID3048869 Css NA 0.1104 mg/L PBTK NA 95% Rat Human -DTXSID3048940 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048940 Fup NA 0.5317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048940 Vd NA 0.3653 L/kg 1compartment NA NA Human Human +DTXSID3048869 TK.Half.Life NA 1.009 hours 1compartment NA NA Rat Human +DTXSID3048869 Css NA 0.01122 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048869 Css NA 0.06057 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048869 Css NA 0.008545 mg/L PBTK NA 50% Rat Human +DTXSID3048869 Css NA 0.04234 mg/L PBTK NA 95% Rat Human +DTXSID3048940 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048940 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048940 Vd NA 0.423 L/kg 1compartment NA NA Human Human DTXSID3048940 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048940 TK.Half.Life NA 4.443 hours 1compartment NA NA Human Human -DTXSID3048940 Css NA 1.537 mg/L 3compartmentss NA 50% Human Human -DTXSID3048940 Css NA 8.696 mg/L 3compartmentss NA 95% Human Human -DTXSID3048940 Css NA 1.07 mg/L PBTK NA 50% Human Human -DTXSID3048940 Css NA 5.276 mg/L PBTK NA 95% Human Human -DTXSID3048940 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048940 Fup NA 0.5317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048940 Vd NA 0.3814 L/kg 1compartment NA NA Rat Human +DTXSID3048940 TK.Half.Life NA 3.391 hours 1compartment NA NA Human Human +DTXSID3048940 Css NA 0.9506 mg/L 3compartmentss NA 50% Human Human +DTXSID3048940 Css NA 5.446 mg/L 3compartmentss NA 95% Human Human +DTXSID3048940 Css NA 0.6915 mg/L PBTK NA 50% Human Human +DTXSID3048940 Css NA 3.405 mg/L PBTK NA 95% Human Human +DTXSID3048940 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048940 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048940 Vd NA 0.4488 L/kg 1compartment NA NA Rat Human DTXSID3048940 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048940 TK.Half.Life NA 1.581 hours 1compartment NA NA Rat Human -DTXSID3048940 Css NA 0.4094 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048940 Css NA 1.999 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048940 Css NA 0.2713 mg/L PBTK NA 50% Rat Human -DTXSID3048940 Css NA 1.138 mg/L PBTK NA 95% Rat Human -DTXSID3048942 Clint NA 128.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048942 Fup NA 0.0435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048942 Vd NA 2.918 L/kg 1compartment NA NA Human Human -DTXSID3048942 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048942 TK.Half.Life NA 8.212 hours 1compartment NA NA Human Human -DTXSID3048942 Css NA 0.2697 mg/L 3compartmentss NA 50% Human Human -DTXSID3048942 Css NA 1.714 mg/L 3compartmentss NA 95% Human Human -DTXSID3048942 Css NA 0.1849 mg/L PBTK NA 50% Human Human -DTXSID3048942 Css NA 1.139 mg/L PBTK NA 95% Human Human -DTXSID3048942 Clint NA 128.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048942 Fup NA 0.0435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048942 Vd NA 2.187 L/kg 1compartment NA NA Rat Human -DTXSID3048942 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048942 TK.Half.Life NA 1.771 hours 1compartment NA NA Rat Human -DTXSID3048942 Css NA 0.1511 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048942 Css NA 0.8006 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048942 Css NA 0.09904 mg/L PBTK NA 50% Rat Human -DTXSID3048942 Css NA 0.5073 mg/L PBTK NA 95% Rat Human -DTXSID3048944 Clint NA 5.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048944 Fup NA 0.0259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048944 Vd NA 0.4096 L/kg 1compartment NA NA Human Human -DTXSID3048944 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3048944 TK.Half.Life NA 10.29 hours 1compartment NA NA Human Human -DTXSID3048944 Css NA 4.539 mg/L 3compartmentss NA 50% Human Human -DTXSID3048944 Css NA 37.61 mg/L 3compartmentss NA 95% Human Human -DTXSID3048944 Css NA 2.714 mg/L PBTK NA 50% Human Human -DTXSID3048944 Css NA 21.64 mg/L PBTK NA 95% Human Human -DTXSID3048944 Clint NA 5.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048944 Fup NA 0.0259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048944 Vd NA 0.3346 L/kg 1compartment NA NA Rat Human +DTXSID3048940 TK.Half.Life NA 1.226 hours 1compartment NA NA Rat Human +DTXSID3048940 Css NA 0.01808 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048940 Css NA 0.1259 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048940 Css NA 0.01258 mg/L PBTK NA 50% Rat Human +DTXSID3048940 Css NA 0.07664 mg/L PBTK NA 95% Rat Human +DTXSID3048942 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048942 Fup 0.0246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048942 Vd NA 2.883 L/kg 1compartment NA NA Human Human +DTXSID3048942 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID3048942 TK.Half.Life NA 44.83 hours 1compartment NA NA Human Human +DTXSID3048942 Css NA 1.97 mg/L 3compartmentss NA 50% Human Human +DTXSID3048942 Css NA 13.71 mg/L 3compartmentss NA 95% Human Human +DTXSID3048942 Css NA 1.335 mg/L PBTK NA 50% Human Human +DTXSID3048942 Css NA 8.951 mg/L PBTK NA 95% Human Human +DTXSID3048942 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048942 Fup 0.0246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048942 Vd NA 2.158 L/kg 1compartment NA NA Rat Human +DTXSID3048942 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3048942 TK.Half.Life NA 8.156 hours 1compartment NA NA Rat Human +DTXSID3048942 Css NA 0.2565 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048942 Css NA 1.41 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048942 Css NA 0.172 mg/L PBTK NA 50% Rat Human +DTXSID3048942 Css NA 0.9229 mg/L PBTK NA 95% Rat Human +DTXSID3048944 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048944 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048944 Vd NA 1.011 L/kg 1compartment NA NA Human Human +DTXSID3048944 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048944 TK.Half.Life NA 3.107 hours 1compartment NA NA Human Human +DTXSID3048944 Css NA 0.2407 mg/L 3compartmentss NA 50% Human Human +DTXSID3048944 Css NA 1.497 mg/L 3compartmentss NA 95% Human Human +DTXSID3048944 Css NA 0.1838 mg/L PBTK NA 50% Human Human +DTXSID3048944 Css NA 1.037 mg/L PBTK NA 95% Human Human +DTXSID3048944 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048944 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048944 Vd NA 0.857 L/kg 1compartment NA NA Rat Human DTXSID3048944 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048944 TK.Half.Life NA 5.208 hours 1compartment NA NA Rat Human -DTXSID3048944 Css NA 2.372 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048944 Css NA 15.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048944 Css NA 1.32 mg/L PBTK NA 50% Rat Human -DTXSID3048944 Css NA 8.422 mg/L PBTK NA 95% Rat Human -DTXSID3048946 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048946 Fup NA 0.3227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048946 Vd NA 3.138 L/kg 1compartment NA NA Human Human -DTXSID3048946 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID3048946 TK.Half.Life NA 99730 hours 1compartment NA NA Human Human -DTXSID3048946 Css NA 3578 mg/L 3compartmentss NA 50% Human Human -DTXSID3048946 Css NA 9262 mg/L 3compartmentss NA 95% Human Human -DTXSID3048946 Css NA 2499 mg/L PBTK NA 50% Human Human -DTXSID3048946 Css NA 5990 mg/L PBTK NA 95% Human Human -DTXSID3048946 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048946 Fup NA 0.3227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048946 Vd NA 2.351 L/kg 1compartment NA NA Rat Human -DTXSID3048946 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID3048946 TK.Half.Life NA 6080 hours 1compartment NA NA Rat Human -DTXSID3048946 Css NA 971.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048946 Css NA 2127 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048946 Css NA 649.1 mg/L PBTK NA 50% Rat Human -DTXSID3048946 Css NA 1286 mg/L PBTK NA 95% Rat Human -DTXSID3048948 Clint NA 11.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048948 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048948 Vd NA 2.779 L/kg 1compartment NA NA Human Human -DTXSID3048948 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3048948 TK.Half.Life NA 39.65 hours 1compartment NA NA Human Human -DTXSID3048948 Css NA 1.836 mg/L 3compartmentss NA 50% Human Human -DTXSID3048948 Css NA 10.94 mg/L 3compartmentss NA 95% Human Human -DTXSID3048948 Css NA 1.269 mg/L PBTK NA 50% Human Human -DTXSID3048948 Css NA 7.21 mg/L PBTK NA 95% Human Human -DTXSID3048948 Clint NA 11.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048948 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048948 Vd NA 2.085 L/kg 1compartment NA NA Rat Human -DTXSID3048948 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3048948 TK.Half.Life NA 7.941 hours 1compartment NA NA Rat Human -DTXSID3048948 Css NA 1.009 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048948 Css NA 4.657 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048948 Css NA 0.6601 mg/L PBTK NA 50% Rat Human -DTXSID3048948 Css NA 2.983 mg/L PBTK NA 95% Rat Human -DTXSID3048990 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048990 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048990 Vd NA 0.7342 L/kg 1compartment NA NA Human Human -DTXSID3048990 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048990 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human -DTXSID3048990 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human -DTXSID3048990 Css NA 6.515 mg/L 3compartmentss NA 95% Human Human -DTXSID3048990 Css NA 0.8344 mg/L PBTK NA 50% Human Human -DTXSID3048990 Css NA 4.14 mg/L PBTK NA 95% Human Human -DTXSID3048990 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048990 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048990 Vd NA 0.7548 L/kg 1compartment NA NA Rat Human -DTXSID3048990 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048990 TK.Half.Life NA 2.172 hours 1compartment NA NA Rat Human -DTXSID3048990 Css NA 0.2618 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048990 Css NA 1.629 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048990 Css NA 0.208 mg/L PBTK NA 50% Rat Human -DTXSID3048990 Css NA 0.9689 mg/L PBTK NA 95% Rat Human -DTXSID3048992 Clint NA 30.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048992 Fup NA 0.0828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048992 Vd NA 0.7583 L/kg 1compartment NA NA Human Human +DTXSID3048944 TK.Half.Life NA 1.455 hours 1compartment NA NA Rat Human +DTXSID3048944 Css NA 0.01041 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048944 Css NA 0.07413 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048944 Css NA 0.008077 mg/L PBTK NA 50% Rat Human +DTXSID3048944 Css NA 0.04984 mg/L PBTK NA 95% Rat Human +DTXSID3048948 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048948 Fup 0.0671 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048948 Vd NA 2.245 L/kg 1compartment NA NA Human Human +DTXSID3048948 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3048948 TK.Half.Life NA 11.08 hours 1compartment NA NA Human Human +DTXSID3048948 Css NA 0.605 mg/L 3compartmentss NA 50% Human Human +DTXSID3048948 Css NA 4.332 mg/L 3compartmentss NA 95% Human Human +DTXSID3048948 Css NA 0.4055 mg/L PBTK NA 50% Human Human +DTXSID3048948 Css NA 2.775 mg/L PBTK NA 95% Human Human +DTXSID3048948 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048948 Fup 0.0671 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048948 Vd NA 1.687 L/kg 1compartment NA NA Rat Human +DTXSID3048948 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3048948 TK.Half.Life NA 3.271 hours 1compartment NA NA Rat Human +DTXSID3048948 Css NA 0.07797 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048948 Css NA 0.438 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048948 Css NA 0.05111 mg/L PBTK NA 50% Rat Human +DTXSID3048948 Css NA 0.2743 mg/L PBTK NA 95% Rat Human +DTXSID3048992 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048992 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048992 Vd NA 0.8882 L/kg 1compartment NA NA Human Human DTXSID3048992 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3048992 TK.Half.Life NA 1.786 hours 1compartment NA NA Human Human -DTXSID3048992 Css NA 0.255 mg/L 3compartmentss NA 50% Human Human -DTXSID3048992 Css NA 2.054 mg/L 3compartmentss NA 95% Human Human -DTXSID3048992 Css NA 0.1616 mg/L PBTK NA 50% Human Human -DTXSID3048992 Css NA 1.249 mg/L PBTK NA 95% Human Human -DTXSID3048992 Clint NA 30.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048992 Fup NA 0.0828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048992 Vd NA 0.6078 L/kg 1compartment NA NA Rat Human +DTXSID3048992 TK.Half.Life NA 2.429 hours 1compartment NA NA Human Human +DTXSID3048992 Css NA 0.2118 mg/L 3compartmentss NA 50% Human Human +DTXSID3048992 Css NA 1.356 mg/L 3compartmentss NA 95% Human Human +DTXSID3048992 Css NA 0.1544 mg/L PBTK NA 50% Human Human +DTXSID3048992 Css NA 0.8958 mg/L PBTK NA 95% Human Human +DTXSID3048992 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048992 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048992 Vd NA 0.7728 L/kg 1compartment NA NA Rat Human DTXSID3048992 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048992 TK.Half.Life NA 0.813 hours 1compartment NA NA Rat Human -DTXSID3048992 Css NA 0.1447 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048992 Css NA 0.9237 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048992 Css NA 0.08572 mg/L PBTK NA 50% Rat Human -DTXSID3048992 Css NA 0.5253 mg/L PBTK NA 95% Rat Human -DTXSID3048996 Clint NA 126.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048996 Fup NA 0.0089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048996 Vd NA 7.412 L/kg 1compartment NA NA Human Human -DTXSID3048996 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3048996 TK.Half.Life NA 41.71 hours 1compartment NA NA Human Human -DTXSID3048996 Css NA 0.425 mg/L 3compartmentss NA 50% Human Human -DTXSID3048996 Css NA 2.587 mg/L 3compartmentss NA 95% Human Human -DTXSID3048996 Css NA 0.4176 mg/L PBTK NA 50% Human Human -DTXSID3048996 Css NA 2.445 mg/L PBTK NA 95% Human Human -DTXSID3048996 Clint NA 126.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048996 Fup NA 0.0089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048996 Vd NA 5.759 L/kg 1compartment NA NA Rat Human -DTXSID3048996 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3048996 TK.Half.Life NA 6.545 hours 1compartment NA NA Rat Human -DTXSID3048996 Css NA 0.2364 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048996 Css NA 1.045 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048996 Css NA 0.2288 mg/L PBTK NA 50% Rat Human -DTXSID3048996 Css NA 1.036 mg/L PBTK NA 95% Rat Human +DTXSID3048992 TK.Half.Life NA 1.177 hours 1compartment NA NA Rat Human +DTXSID3048992 Css NA 0.009248 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048992 Css NA 0.07052 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048992 Css NA 0.006638 mg/L PBTK NA 50% Rat Human +DTXSID3048992 Css NA 0.04579 mg/L PBTK NA 95% Rat Human +DTXSID3048996 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048996 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048996 Vd NA 3.115 L/kg 1compartment NA NA Human Human +DTXSID3048996 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID3048996 TK.Half.Life NA 92.79 hours 1compartment NA NA Human Human +DTXSID3048996 Css NA 3.464 mg/L 3compartmentss NA 50% Human Human +DTXSID3048996 Css NA 20.64 mg/L 3compartmentss NA 95% Human Human +DTXSID3048996 Css NA 2.396 mg/L PBTK NA 50% Human Human +DTXSID3048996 Css NA 14.3 mg/L PBTK NA 95% Human Human +DTXSID3048996 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048996 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048996 Vd NA 2.334 L/kg 1compartment NA NA Rat Human +DTXSID3048996 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID3048996 TK.Half.Life NA 12.55 hours 1compartment NA NA Rat Human +DTXSID3048996 Css NA 0.455 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048996 Css NA 2.175 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048996 Css NA 0.312 mg/L PBTK NA 50% Rat Human +DTXSID3048996 Css NA 1.491 mg/L PBTK NA 95% Rat Human DTXSID3048998 Clint 9.844 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID3048998 Fup NA 0.0252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3048998 Vd NA 0.874 L/kg 1compartment NA NA Human Human +DTXSID3048998 Fup 0.0488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3048998 Vd NA 1.648 L/kg 1compartment NA NA Human Human DTXSID3048998 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3048998 TK.Half.Life NA 12.86 hours 1compartment NA NA Human Human -DTXSID3048998 Css NA 2.547 mg/L 3compartmentss NA 50% Human Human -DTXSID3048998 Css NA 21.48 mg/L 3compartmentss NA 95% Human Human -DTXSID3048998 Css NA 1.557 mg/L PBTK NA 50% Human Human -DTXSID3048998 Css NA 12.79 mg/L PBTK NA 95% Human Human +DTXSID3048998 TK.Half.Life NA 15.89 hours 1compartment NA NA Human Human +DTXSID3048998 Css NA 1.412 mg/L 3compartmentss NA 50% Human Human +DTXSID3048998 Css NA 9.893 mg/L 3compartmentss NA 95% Human Human +DTXSID3048998 Css NA 0.9128 mg/L PBTK NA 50% Human Human +DTXSID3048998 Css NA 6.036 mg/L PBTK NA 95% Human Human DTXSID3048998 Clint 9.844 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID3048998 Fup NA 0.0252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3048998 Vd NA 0.6572 L/kg 1compartment NA NA Rat Human +DTXSID3048998 Fup 0.0488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3048998 Vd NA 1.237 L/kg 1compartment NA NA Rat Human DTXSID3048998 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3048998 TK.Half.Life NA 5.771 hours 1compartment NA NA Rat Human -DTXSID3048998 Css NA 1.392 mg/L 3compartmentss NA 50% Rat Human -DTXSID3048998 Css NA 9.198 mg/L 3compartmentss NA 95% Rat Human -DTXSID3048998 Css NA 0.7899 mg/L PBTK NA 50% Rat Human -DTXSID3048998 Css NA 5.043 mg/L PBTK NA 95% Rat Human -DTXSID3049041 Clint NA 60.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049041 Fup NA 0.2174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049041 Vd NA 1.447 L/kg 1compartment NA NA Human Human +DTXSID3048998 TK.Half.Life NA 5.815 hours 1compartment NA NA Rat Human +DTXSID3048998 Css NA 0.1776 mg/L 3compartmentss NA 50% Rat Human +DTXSID3048998 Css NA 0.9904 mg/L 3compartmentss NA 95% Rat Human +DTXSID3048998 Css NA 0.1117 mg/L PBTK NA 50% Rat Human +DTXSID3048998 Css NA 0.5861 mg/L PBTK NA 95% Rat Human +DTXSID3049041 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049041 Fup 0.422 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049041 Vd NA 2.238 L/kg 1compartment NA NA Human Human DTXSID3049041 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049041 TK.Half.Life NA 1.429 hours 1compartment NA NA Human Human -DTXSID3049041 Css NA 0.03366 mg/L 3compartmentss NA 50% Human Human -DTXSID3049041 Css NA 0.2532 mg/L 3compartmentss NA 95% Human Human -DTXSID3049041 Css NA 0.02626 mg/L PBTK NA 50% Human Human -DTXSID3049041 Css NA 0.1811 mg/L PBTK NA 95% Human Human -DTXSID3049041 Clint NA 60.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049041 Fup NA 0.2174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049041 Vd NA 1.385 L/kg 1compartment NA NA Rat Human +DTXSID3049041 TK.Half.Life NA 4.263 hours 1compartment NA NA Human Human +DTXSID3049041 Css NA 0.1278 mg/L 3compartmentss NA 50% Human Human +DTXSID3049041 Css NA 0.9417 mg/L 3compartmentss NA 95% Human Human +DTXSID3049041 Css NA 0.1221 mg/L PBTK NA 50% Human Human +DTXSID3049041 Css NA 0.7271 mg/L PBTK NA 95% Human Human +DTXSID3049041 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049041 Fup 0.422 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049041 Vd NA 2.16 L/kg 1compartment NA NA Rat Human DTXSID3049041 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049041 TK.Half.Life NA 0.6849 hours 1compartment NA NA Rat Human -DTXSID3049041 Css NA 0.01856 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049041 Css NA 0.1104 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049041 Css NA 0.01389 mg/L PBTK NA 50% Rat Human -DTXSID3049041 Css NA 0.07599 mg/L PBTK NA 95% Rat Human -DTXSID3049043 Clint NA 86.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049043 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049043 Vd NA 3.115 L/kg 1compartment NA NA Human Human -DTXSID3049043 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3049043 TK.Half.Life NA 25.22 hours 1compartment NA NA Human Human -DTXSID3049043 Css NA 0.8952 mg/L 3compartmentss NA 50% Human Human -DTXSID3049043 Css NA 4.968 mg/L 3compartmentss NA 95% Human Human -DTXSID3049043 Css NA 0.6204 mg/L PBTK NA 50% Human Human -DTXSID3049043 Css NA 3.393 mg/L PBTK NA 95% Human Human -DTXSID3049043 Clint NA 86.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049043 Fup NA 0.0146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049043 Vd NA 2.334 L/kg 1compartment NA NA Rat Human -DTXSID3049043 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3049043 TK.Half.Life NA 3.779 hours 1compartment NA NA Rat Human -DTXSID3049043 Css NA 0.5044 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049043 Css NA 2.169 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049043 Css NA 0.3346 mg/L PBTK NA 50% Rat Human -DTXSID3049043 Css NA 1.445 mg/L PBTK NA 95% Rat Human -DTXSID3049045 Clint NA 70.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049045 Fup NA 0.2202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049045 Vd NA 2.103 L/kg 1compartment NA NA Human Human +DTXSID3049041 TK.Half.Life NA 2.23 hours 1compartment NA NA Rat Human +DTXSID3049041 Css NA 0.01472 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049041 Css NA 0.08322 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049041 Css NA 0.01436 mg/L PBTK NA 50% Rat Human +DTXSID3049041 Css NA 0.06231 mg/L PBTK NA 95% Rat Human +DTXSID3049043 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049043 Fup 0.0147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049043 Vd NA 2.987 L/kg 1compartment NA NA Human Human +DTXSID3049043 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID3049043 TK.Half.Life NA 65.08 hours 1compartment NA NA Human Human +DTXSID3049043 Css NA 2.725 mg/L 3compartmentss NA 50% Human Human +DTXSID3049043 Css NA 18.03 mg/L 3compartmentss NA 95% Human Human +DTXSID3049043 Css NA 1.865 mg/L PBTK NA 50% Human Human +DTXSID3049043 Css NA 11.93 mg/L PBTK NA 95% Human Human +DTXSID3049043 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049043 Fup 0.0147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049043 Vd NA 2.235 L/kg 1compartment NA NA Rat Human +DTXSID3049043 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID3049043 TK.Half.Life NA 10.48 hours 1compartment NA NA Rat Human +DTXSID3049043 Css NA 0.3552 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049043 Css NA 2.073 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049043 Css NA 0.2401 mg/L PBTK NA 50% Rat Human +DTXSID3049043 Css NA 1.353 mg/L PBTK NA 95% Rat Human +DTXSID3049045 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049045 Fup 0.181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049045 Vd NA 1.415 L/kg 1compartment NA NA Human Human DTXSID3049045 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049045 TK.Half.Life NA 1.783 hours 1compartment NA NA Human Human -DTXSID3049045 Css NA 0.02434 mg/L 3compartmentss NA 50% Human Human -DTXSID3049045 Css NA 0.1877 mg/L 3compartmentss NA 95% Human Human -DTXSID3049045 Css NA 0.02134 mg/L PBTK NA 50% Human Human -DTXSID3049045 Css NA 0.1447 mg/L PBTK NA 95% Human Human -DTXSID3049045 Clint NA 70.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049045 Fup NA 0.2202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049045 Vd NA 2.083 L/kg 1compartment NA NA Rat Human +DTXSID3049045 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human +DTXSID3049045 Css NA 0.388 mg/L 3compartmentss NA 50% Human Human +DTXSID3049045 Css NA 2.26 mg/L 3compartmentss NA 95% Human Human +DTXSID3049045 Css NA 0.2732 mg/L PBTK NA 50% Human Human +DTXSID3049045 Css NA 1.517 mg/L PBTK NA 95% Human Human +DTXSID3049045 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049045 Fup 0.181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049045 Vd NA 1.111 L/kg 1compartment NA NA Rat Human DTXSID3049045 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049045 TK.Half.Life NA 0.881 hours 1compartment NA NA Rat Human -DTXSID3049045 Css NA 0.01306 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049045 Css NA 0.08457 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049045 Css NA 0.01128 mg/L PBTK NA 50% Rat Human -DTXSID3049045 Css NA 0.06314 mg/L PBTK NA 95% Rat Human -DTXSID3049047 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3049045 TK.Half.Life NA 2.469 hours 1compartment NA NA Rat Human +DTXSID3049045 Css NA 0.0175 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049045 Css NA 0.1155 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049045 Css NA 0.01214 mg/L PBTK NA 50% Rat Human +DTXSID3049045 Css NA 0.07454 mg/L PBTK NA 95% Rat Human +DTXSID3049047 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3049047 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3049047 Vd NA 0.1953 L/kg 1compartment NA NA Human Human +DTXSID3049047 Vd NA 2.186 L/kg 1compartment NA NA Human Human DTXSID3049047 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049047 TK.Half.Life NA 0.3759 hours 1compartment NA NA Human Human -DTXSID3049047 Css NA 0.1234 mg/L 3compartmentss NA 50% Human Human -DTXSID3049047 Css NA 1.095 mg/L 3compartmentss NA 95% Human Human -DTXSID3049047 Css NA 0.07508 mg/L PBTK NA 50% Human Human -DTXSID3049047 Css NA 0.6398 mg/L PBTK NA 95% Human Human -DTXSID3049047 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3049047 TK.Half.Life NA 13.11 hours 1compartment NA NA Human Human +DTXSID3049047 Css NA 0.8398 mg/L 3compartmentss NA 50% Human Human +DTXSID3049047 Css NA 5.881 mg/L 3compartmentss NA 95% Human Human +DTXSID3049047 Css NA 0.5036 mg/L PBTK NA 50% Human Human +DTXSID3049047 Css NA 3.528 mg/L PBTK NA 95% Human Human +DTXSID3049047 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3049047 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3049047 Vd NA 0.1947 L/kg 1compartment NA NA Rat Human +DTXSID3049047 Vd NA 1.636 L/kg 1compartment NA NA Rat Human DTXSID3049047 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049047 TK.Half.Life NA 0.214 hours 1compartment NA NA Rat Human -DTXSID3049047 Css NA 0.1064 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049047 Css NA 0.8055 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049047 Css NA 0.06083 mg/L PBTK NA 50% Rat Human -DTXSID3049047 Css NA 0.4468 mg/L PBTK NA 95% Rat Human -DTXSID3049049 Clint NA 54.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3049047 TK.Half.Life NA 3.921 hours 1compartment NA NA Rat Human +DTXSID3049047 Css NA 0.1031 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049047 Css NA 0.5559 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049047 Css NA 0.06407 mg/L PBTK NA 50% Rat Human +DTXSID3049047 Css NA 0.3448 mg/L PBTK NA 95% Rat Human +DTXSID3049049 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID3049049 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3049049 Vd NA 0.732 L/kg 1compartment NA NA Human Human -DTXSID3049049 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049049 TK.Half.Life NA 9.885 hours 1compartment NA NA Human Human -DTXSID3049049 Css NA 2.37 mg/L 3compartmentss NA 50% Human Human -DTXSID3049049 Css NA 17.76 mg/L 3compartmentss NA 95% Human Human -DTXSID3049049 Css NA 1.409 mg/L PBTK NA 50% Human Human -DTXSID3049049 Css NA 10.33 mg/L PBTK NA 95% Human Human -DTXSID3049049 Clint NA 54.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3049049 Vd NA 0.6485 L/kg 1compartment NA NA Human Human +DTXSID3049049 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID3049049 TK.Half.Life NA 49.44 hours 1compartment NA NA Human Human +DTXSID3049049 Css NA 13.79 mg/L 3compartmentss NA 50% Human Human +DTXSID3049049 Css NA 91.58 mg/L 3compartmentss NA 95% Human Human +DTXSID3049049 Css NA 8.14 mg/L PBTK NA 50% Human Human +DTXSID3049049 Css NA 54.3 mg/L PBTK NA 95% Human Human +DTXSID3049049 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID3049049 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3049049 Vd NA 0.5395 L/kg 1compartment NA NA Rat Human -DTXSID3049049 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049049 TK.Half.Life NA 4.618 hours 1compartment NA NA Rat Human -DTXSID3049049 Css NA 1.361 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049049 Css NA 8.025 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049049 Css NA 0.7527 mg/L PBTK NA 50% Rat Human -DTXSID3049049 Css NA 4.414 mg/L PBTK NA 95% Rat Human -DTXSID3049201 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049201 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049201 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID3049201 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049201 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID3049201 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID3049201 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID3049201 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID3049201 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID3049201 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049201 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049201 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human -DTXSID3049201 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049201 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID3049201 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049201 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049201 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID3049201 Css NA 1.296 mg/L PBTK NA 95% Rat Human -DTXSID3049209 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049209 Fup NA 0.0531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049209 Vd NA 2.894 L/kg 1compartment NA NA Human Human -DTXSID3049209 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3049209 TK.Half.Life NA 37.05 hours 1compartment NA NA Human Human -DTXSID3049209 Css NA 1.608 mg/L 3compartmentss NA 50% Human Human -DTXSID3049209 Css NA 10.03 mg/L 3compartmentss NA 95% Human Human -DTXSID3049209 Css NA 1.107 mg/L PBTK NA 50% Human Human -DTXSID3049209 Css NA 6.683 mg/L PBTK NA 95% Human Human -DTXSID3049209 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049209 Fup NA 0.0531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049209 Vd NA 2.17 L/kg 1compartment NA NA Rat Human -DTXSID3049209 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID3049209 TK.Half.Life NA 6.749 hours 1compartment NA NA Rat Human -DTXSID3049209 Css NA 0.8965 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049209 Css NA 4.656 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049209 Css NA 0.5862 mg/L PBTK NA 50% Rat Human -DTXSID3049209 Css NA 2.973 mg/L PBTK NA 95% Rat Human -DTXSID3049253 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049253 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049253 Vd NA 3.157 L/kg 1compartment NA NA Human Human -DTXSID3049253 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049253 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human -DTXSID3049253 Css NA 0.3557 mg/L 3compartmentss NA 50% Human Human -DTXSID3049253 Css NA 2.326 mg/L 3compartmentss NA 95% Human Human -DTXSID3049253 Css NA 0.2508 mg/L PBTK NA 50% Human Human -DTXSID3049253 Css NA 1.568 mg/L PBTK NA 95% Human Human -DTXSID3049253 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049253 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049253 Vd NA 2.375 L/kg 1compartment NA NA Rat Human -DTXSID3049253 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049253 TK.Half.Life NA 2.005 hours 1compartment NA NA Rat Human -DTXSID3049253 Css NA 0.199 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049253 Css NA 1.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049253 Css NA 0.1344 mg/L PBTK NA 50% Rat Human -DTXSID3049253 Css NA 0.7061 mg/L PBTK NA 95% Rat Human -DTXSID3049330 Clint NA 0.1014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049330 Fup NA 0.4283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049330 Vd NA 0.4182 L/kg 1compartment NA NA Human Human +DTXSID3049049 Vd NA 0.4803 L/kg 1compartment NA NA Rat Human +DTXSID3049049 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3049049 TK.Half.Life NA 23.17 hours 1compartment NA NA Rat Human +DTXSID3049049 Css NA 1.772 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049049 Css NA 8.885 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049049 Css NA 1.011 mg/L PBTK NA 50% Rat Human +DTXSID3049049 Css NA 5.036 mg/L PBTK NA 95% Rat Human +DTXSID30491982 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30491982 Fup 0.0151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30491982 Vd NA 3.753 L/kg 1compartment NA NA Human Human +DTXSID30491982 Days.Css NA 19 Days PBTK NA NA Human Human +DTXSID30491982 TK.Half.Life NA 113.3 hours 1compartment NA NA Human Human +DTXSID30491982 Css NA 3.235 mg/L 3compartmentss NA 50% Human Human +DTXSID30491982 Css NA 18.68 mg/L 3compartmentss NA 95% Human Human +DTXSID30491982 Css NA 2.366 mg/L PBTK NA 50% Human Human +DTXSID30491982 Css NA 13.75 mg/L PBTK NA 95% Human Human +DTXSID30491982 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30491982 Fup 0.0151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30491982 Vd NA 2.831 L/kg 1compartment NA NA Rat Human +DTXSID30491982 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID30491982 TK.Half.Life NA 15.28 hours 1compartment NA NA Rat Human +DTXSID30491982 Css NA 0.4266 mg/L 3compartmentss NA 50% Rat Human +DTXSID30491982 Css NA 2.134 mg/L 3compartmentss NA 95% Rat Human +DTXSID30491982 Css NA 0.31 mg/L PBTK NA 50% Rat Human +DTXSID30491982 Css NA 1.604 mg/L PBTK NA 95% Rat Human +DTXSID3049330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049330 Fup 0.661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049330 Vd NA 1.197 L/kg 1compartment NA NA Human Human DTXSID3049330 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049330 TK.Half.Life NA 5.419 hours 1compartment NA NA Human Human -DTXSID3049330 Css NA 1.489 mg/L 3compartmentss NA 50% Human Human -DTXSID3049330 Css NA 6.877 mg/L 3compartmentss NA 95% Human Human -DTXSID3049330 Css NA 1.054 mg/L PBTK NA 50% Human Human -DTXSID3049330 Css NA 4.262 mg/L PBTK NA 95% Human Human -DTXSID3049330 Clint NA 0.1014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049330 Fup NA 0.4283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049330 Vd NA 0.4219 L/kg 1compartment NA NA Rat Human +DTXSID3049330 TK.Half.Life NA 1.006 hours 1compartment NA NA Human Human +DTXSID3049330 Css NA 0.02964 mg/L 3compartmentss NA 50% Human Human +DTXSID3049330 Css NA 0.3254 mg/L 3compartmentss NA 95% Human Human +DTXSID3049330 Css NA 0.02534 mg/L PBTK NA 50% Human Human +DTXSID3049330 Css NA 0.2251 mg/L PBTK NA 95% Human Human +DTXSID3049330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049330 Fup 0.661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049330 Vd NA 1.091 L/kg 1compartment NA NA Rat Human DTXSID3049330 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049330 TK.Half.Life NA 2.009 hours 1compartment NA NA Rat Human -DTXSID3049330 Css NA 0.4456 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049330 Css NA 1.739 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049330 Css NA 0.3008 mg/L PBTK NA 50% Rat Human -DTXSID3049330 Css NA 1.01 mg/L PBTK NA 95% Rat Human -DTXSID3049334 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049334 Fup NA 0.839 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049334 Vd NA 0.6636 L/kg 1compartment NA NA Human Human +DTXSID3049330 TK.Half.Life NA 0.4463 hours 1compartment NA NA Rat Human +DTXSID3049330 Css NA 0.003508 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049330 Css NA 0.03281 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049330 Css NA 0.003078 mg/L PBTK NA 50% Rat Human +DTXSID3049330 Css NA 0.02316 mg/L PBTK NA 95% Rat Human +DTXSID3049332 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049332 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049332 Vd NA 0.38 L/kg 1compartment NA NA Human Human +DTXSID3049332 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3049332 TK.Half.Life NA 8.719 hours 1compartment NA NA Human Human +DTXSID3049332 Css NA 2.717 mg/L 3compartmentss NA 50% Human Human +DTXSID3049332 Css NA 10.03 mg/L 3compartmentss NA 95% Human Human +DTXSID3049332 Css NA 1.837 mg/L PBTK NA 50% Human Human +DTXSID3049332 Css NA 6.169 mg/L PBTK NA 95% Human Human +DTXSID3049332 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049332 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049332 Vd NA 0.3962 L/kg 1compartment NA NA Rat Human +DTXSID3049332 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3049332 TK.Half.Life NA 3.097 hours 1compartment NA NA Rat Human +DTXSID3049332 Css NA 0.1736 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049332 Css NA 0.5554 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049332 Css NA 0.1148 mg/L PBTK NA 50% Rat Human +DTXSID3049332 Css NA 0.3301 mg/L PBTK NA 95% Rat Human +DTXSID3049334 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049334 Fup 0.822 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049334 Vd NA 0.6885 L/kg 1compartment NA NA Human Human DTXSID3049334 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049334 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human -DTXSID3049334 Css NA 1.018 mg/L 3compartmentss NA 50% Human Human -DTXSID3049334 Css NA 5.866 mg/L 3compartmentss NA 95% Human Human -DTXSID3049334 Css NA 0.7987 mg/L PBTK NA 50% Human Human -DTXSID3049334 Css NA 3.732 mg/L PBTK NA 95% Human Human -DTXSID3049334 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049334 Fup NA 0.839 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049334 Vd NA 0.6677 L/kg 1compartment NA NA Rat Human +DTXSID3049334 TK.Half.Life NA 0.5523 hours 1compartment NA NA Human Human +DTXSID3049334 Css NA 0.02175 mg/L 3compartmentss NA 50% Human Human +DTXSID3049334 Css NA 0.2403 mg/L 3compartmentss NA 95% Human Human +DTXSID3049334 Css NA 0.0169 mg/L PBTK NA 50% Human Human +DTXSID3049334 Css NA 0.1666 mg/L PBTK NA 95% Human Human +DTXSID3049334 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049334 Fup 0.822 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049334 Vd NA 0.6866 L/kg 1compartment NA NA Rat Human DTXSID3049334 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049334 TK.Half.Life NA 1.757 hours 1compartment NA NA Rat Human -DTXSID3049334 Css NA 0.2598 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049334 Css NA 1.502 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049334 Css NA 0.1982 mg/L PBTK NA 50% Rat Human -DTXSID3049334 Css NA 0.8859 mg/L PBTK NA 95% Rat Human -DTXSID3049336 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049336 Fup NA 0.9905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049336 Vd NA 0.9188 L/kg 1compartment NA NA Human Human +DTXSID3049334 TK.Half.Life NA 0.2641 hours 1compartment NA NA Rat Human +DTXSID3049334 Css NA 0.0007548 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049334 Css NA 0.0101 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049334 Css NA 0.0005842 mg/L PBTK NA 50% Rat Human +DTXSID3049334 Css NA 0.006625 mg/L PBTK NA 95% Rat Human +DTXSID3049336 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049336 Fup 0.823 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049336 Vd NA 1.143 L/kg 1compartment NA NA Human Human DTXSID3049336 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049336 TK.Half.Life NA 6.001 hours 1compartment NA NA Human Human -DTXSID3049336 Css NA 0.8458 mg/L 3compartmentss NA 50% Human Human -DTXSID3049336 Css NA 5.035 mg/L 3compartmentss NA 95% Human Human -DTXSID3049336 Css NA 0.7222 mg/L PBTK NA 50% Human Human -DTXSID3049336 Css NA 3.256 mg/L PBTK NA 95% Human Human -DTXSID3049336 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049336 Fup NA 0.9905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049336 Vd NA 0.9534 L/kg 1compartment NA NA Rat Human +DTXSID3049336 TK.Half.Life NA 9.098 hours 1compartment NA NA Human Human +DTXSID3049336 Css NA 0.779 mg/L 3compartmentss NA 50% Human Human +DTXSID3049336 Css NA 4.916 mg/L 3compartmentss NA 95% Human Human +DTXSID3049336 Css NA 0.6872 mg/L PBTK NA 50% Human Human +DTXSID3049336 Css NA 3.303 mg/L PBTK NA 95% Human Human +DTXSID3049336 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049336 Fup 0.823 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049336 Vd NA 1.139 L/kg 1compartment NA NA Rat Human DTXSID3049336 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049336 TK.Half.Life NA 2.122 hours 1compartment NA NA Rat Human -DTXSID3049336 Css NA 0.215 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049336 Css NA 1.222 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049336 Css NA 0.1796 mg/L PBTK NA 50% Rat Human -DTXSID3049336 Css NA 0.7468 mg/L PBTK NA 95% Rat Human -DTXSID3049338 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049338 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049338 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID3049338 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3049338 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID3049338 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID3049338 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID3049338 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID3049338 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID3049338 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049338 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049338 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID3049338 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049338 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID3049338 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049338 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049338 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID3049338 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID3049382 Clint NA 29.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049382 Fup NA 0.1016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049382 Vd NA 3.122 L/kg 1compartment NA NA Human Human -DTXSID3049382 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID3049382 TK.Half.Life NA 49.12 hours 1compartment NA NA Human Human -DTXSID3049382 Css NA 1.845 mg/L 3compartmentss NA 50% Human Human -DTXSID3049382 Css NA 11.83 mg/L 3compartmentss NA 95% Human Human -DTXSID3049382 Css NA 1.288 mg/L PBTK NA 50% Human Human -DTXSID3049382 Css NA 7.913 mg/L PBTK NA 95% Human Human -DTXSID3049382 Clint NA 29.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049382 Fup NA 0.1016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049382 Vd NA 2.34 L/kg 1compartment NA NA Rat Human -DTXSID3049382 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID3049382 TK.Half.Life NA 6.856 hours 1compartment NA NA Rat Human -DTXSID3049382 Css NA 1.037 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049382 Css NA 5.553 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049382 Css NA 0.6896 mg/L PBTK NA 50% Rat Human -DTXSID3049382 Css NA 3.568 mg/L PBTK NA 95% Rat Human -DTXSID3049413 Clint NA 3.507 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049413 Fup NA 0.3861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049413 Vd NA 0.4178 L/kg 1compartment NA NA Human Human +DTXSID3049336 TK.Half.Life NA 3.062 hours 1compartment NA NA Rat Human +DTXSID3049336 Css NA 0.01448 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049336 Css NA 0.1152 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049336 Css NA 0.01237 mg/L PBTK NA 50% Rat Human +DTXSID3049336 Css NA 0.0774 mg/L PBTK NA 95% Rat Human +DTXSID3049413 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049413 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049413 Vd NA 0.3032 L/kg 1compartment NA NA Human Human DTXSID3049413 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049413 TK.Half.Life NA 1.266 hours 1compartment NA NA Human Human -DTXSID3049413 Css NA 0.3006 mg/L 3compartmentss NA 50% Human Human -DTXSID3049413 Css NA 1.772 mg/L 3compartmentss NA 95% Human Human -DTXSID3049413 Css NA 0.2122 mg/L PBTK NA 50% Human Human -DTXSID3049413 Css NA 1.133 mg/L PBTK NA 95% Human Human -DTXSID3049413 Clint NA 3.507 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049413 Fup NA 0.3861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049413 Vd NA 0.4189 L/kg 1compartment NA NA Rat Human +DTXSID3049413 TK.Half.Life NA 1.135 hours 1compartment NA NA Human Human +DTXSID3049413 Css NA 0.3902 mg/L 3compartmentss NA 50% Human Human +DTXSID3049413 Css NA 2.342 mg/L 3compartmentss NA 95% Human Human +DTXSID3049413 Css NA 0.2513 mg/L PBTK NA 50% Human Human +DTXSID3049413 Css NA 1.415 mg/L PBTK NA 95% Human Human +DTXSID3049413 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049413 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049413 Vd NA 0.3025 L/kg 1compartment NA NA Rat Human DTXSID3049413 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049413 TK.Half.Life NA 0.7041 hours 1compartment NA NA Rat Human -DTXSID3049413 Css NA 0.1451 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049413 Css NA 0.6388 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049413 Css NA 0.09696 mg/L PBTK NA 50% Rat Human -DTXSID3049413 Css NA 0.3767 mg/L PBTK NA 95% Rat Human -DTXSID3049415 Clint NA 2.418 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049415 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049415 Vd NA 1.862 L/kg 1compartment NA NA Human Human -DTXSID3049415 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049415 TK.Half.Life NA 2.947 hours 1compartment NA NA Human Human -DTXSID3049415 Css NA 0.1441 mg/L 3compartmentss NA 50% Human Human -DTXSID3049415 Css NA 1.236 mg/L 3compartmentss NA 95% Human Human -DTXSID3049415 Css NA 0.1442 mg/L PBTK NA 50% Human Human -DTXSID3049415 Css NA 0.9134 mg/L PBTK NA 95% Human Human -DTXSID3049415 Clint NA 2.418 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049415 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049415 Vd NA 1.906 L/kg 1compartment NA NA Rat Human +DTXSID3049413 TK.Half.Life NA 0.6665 hours 1compartment NA NA Rat Human +DTXSID3049413 Css NA 0.04727 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049413 Css NA 0.1964 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049413 Css NA 0.0296 mg/L PBTK NA 50% Rat Human +DTXSID3049413 Css NA 0.1171 mg/L PBTK NA 95% Rat Human +DTXSID3049415 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049415 Fup 0.773 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049415 Vd NA 1.647 L/kg 1compartment NA NA Human Human +DTXSID3049415 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3049415 TK.Half.Life NA 13.79 hours 1compartment NA NA Human Human +DTXSID3049415 Css NA 0.7476 mg/L 3compartmentss NA 50% Human Human +DTXSID3049415 Css NA 5.347 mg/L 3compartmentss NA 95% Human Human +DTXSID3049415 Css NA 0.7188 mg/L PBTK NA 50% Human Human +DTXSID3049415 Css NA 3.569 mg/L PBTK NA 95% Human Human +DTXSID3049415 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049415 Fup 0.773 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049415 Vd NA 1.68 L/kg 1compartment NA NA Rat Human DTXSID3049415 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049415 TK.Half.Life NA 1.591 hours 1compartment NA NA Rat Human -DTXSID3049415 Css NA 0.06024 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049415 Css NA 0.4404 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049415 Css NA 0.06139 mg/L PBTK NA 50% Rat Human -DTXSID3049415 Css NA 0.2931 mg/L PBTK NA 95% Rat Human +DTXSID3049415 TK.Half.Life NA 4.794 hours 1compartment NA NA Rat Human +DTXSID3049415 Css NA 0.0186 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049415 Css NA 0.1595 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049415 Css NA 0.01761 mg/L PBTK NA 50% Rat Human +DTXSID3049415 Css NA 0.1088 mg/L PBTK NA 95% Rat Human DTXSID3049417 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3049417 Fup NA 0.7735 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3049417 Vd NA 0.5885 L/kg 1compartment NA NA Human Human DTXSID3049417 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID3049417 TK.Half.Life NA 4.926 hours 1compartment NA NA Human Human -DTXSID3049417 Css NA 1.061 mg/L 3compartmentss NA 50% Human Human -DTXSID3049417 Css NA 6.459 mg/L 3compartmentss NA 95% Human Human -DTXSID3049417 Css NA 0.8224 mg/L PBTK NA 50% Human Human -DTXSID3049417 Css NA 4.028 mg/L PBTK NA 95% Human Human +DTXSID3049417 Css NA 0.917 mg/L 3compartmentss NA 50% Human Human +DTXSID3049417 Css NA 5.601 mg/L 3compartmentss NA 95% Human Human +DTXSID3049417 Css NA 0.7105 mg/L PBTK NA 50% Human Human +DTXSID3049417 Css NA 3.53 mg/L PBTK NA 95% Human Human DTXSID3049417 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3049417 Fup NA 0.7735 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3049417 Vd NA 0.6059 L/kg 1compartment NA NA Rat Human DTXSID3049417 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID3049417 TK.Half.Life NA 1.728 hours 1compartment NA NA Rat Human -DTXSID3049417 Css NA 0.2778 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049417 Css NA 1.641 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049417 Css NA 0.2066 mg/L PBTK NA 50% Rat Human -DTXSID3049417 Css NA 0.9584 mg/L PBTK NA 95% Rat Human -DTXSID3049419 Clint NA 19.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049419 Fup NA 0.4719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3049419 Vd NA 3.163 L/kg 1compartment NA NA Human Human +DTXSID3049417 Css NA 0.01732 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049417 Css NA 0.1311 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049417 Css NA 0.01283 mg/L PBTK NA 50% Rat Human +DTXSID3049417 Css NA 0.0805 mg/L PBTK NA 95% Rat Human +DTXSID3049419 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049419 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3049419 Vd NA 1.049 L/kg 1compartment NA NA Human Human DTXSID3049419 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3049419 TK.Half.Life NA 2.557 hours 1compartment NA NA Human Human -DTXSID3049419 Css NA 0.03046 mg/L 3compartmentss NA 50% Human Human -DTXSID3049419 Css NA 0.304 mg/L 3compartmentss NA 95% Human Human -DTXSID3049419 Css NA 0.03608 mg/L PBTK NA 50% Human Human -DTXSID3049419 Css NA 0.2651 mg/L PBTK NA 95% Human Human -DTXSID3049419 Clint NA 19.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049419 Fup NA 0.4719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3049419 Vd NA 3.205 L/kg 1compartment NA NA Rat Human +DTXSID3049419 TK.Half.Life NA 1.773 hours 1compartment NA NA Human Human +DTXSID3049419 Css NA 0.1214 mg/L 3compartmentss NA 50% Human Human +DTXSID3049419 Css NA 0.9218 mg/L 3compartmentss NA 95% Human Human +DTXSID3049419 Css NA 0.1008 mg/L PBTK NA 50% Human Human +DTXSID3049419 Css NA 0.6503 mg/L PBTK NA 95% Human Human +DTXSID3049419 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049419 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3049419 Vd NA 1.071 L/kg 1compartment NA NA Rat Human DTXSID3049419 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3049419 TK.Half.Life NA 1.402 hours 1compartment NA NA Rat Human -DTXSID3049419 Css NA 0.01558 mg/L 3compartmentss NA 50% Rat Human -DTXSID3049419 Css NA 0.1265 mg/L 3compartmentss NA 95% Rat Human -DTXSID3049419 Css NA 0.01835 mg/L PBTK NA 50% Rat Human -DTXSID3049419 Css NA 0.1065 mg/L PBTK NA 95% Rat Human +DTXSID3049419 TK.Half.Life NA 1.005 hours 1compartment NA NA Rat Human +DTXSID3049419 Css NA 0.01386 mg/L 3compartmentss NA 50% Rat Human +DTXSID3049419 Css NA 0.08638 mg/L 3compartmentss NA 95% Rat Human +DTXSID3049419 Css NA 0.01161 mg/L PBTK NA 50% Rat Human +DTXSID3049419 Css NA 0.05782 mg/L PBTK NA 95% Rat Human +DTXSID3051381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3051381 Fup 0.0932 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3051381 Vd NA 0.908 L/kg 1compartment NA NA Human Human +DTXSID3051381 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3051381 TK.Half.Life NA 2.497 hours 1compartment NA NA Human Human +DTXSID3051381 Css NA 0.3026 mg/L 3compartmentss NA 50% Human Human +DTXSID3051381 Css NA 2.542 mg/L 3compartmentss NA 95% Human Human +DTXSID3051381 Css NA 0.1934 mg/L PBTK NA 50% Human Human +DTXSID3051381 Css NA 1.563 mg/L PBTK NA 95% Human Human +DTXSID3051381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3051381 Fup 0.0932 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3051381 Vd NA 0.7101 L/kg 1compartment NA NA Rat Human +DTXSID3051381 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3051381 TK.Half.Life NA 1.099 hours 1compartment NA NA Rat Human +DTXSID3051381 Css NA 0.04003 mg/L 3compartmentss NA 50% Rat Human +DTXSID3051381 Css NA 0.2429 mg/L 3compartmentss NA 95% Rat Human +DTXSID3051381 Css NA 0.02484 mg/L PBTK NA 50% Rat Human +DTXSID3051381 Css NA 0.1432 mg/L PBTK NA 95% Rat Human DTXSID3051707 Clint NA 44.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID3051707 Fup NA 0.6353 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3051707 Vd NA 0.8159 L/kg 1compartment NA NA Human Human +DTXSID3051707 Vd NA 0.8076 L/kg 1compartment NA NA Human Human DTXSID3051707 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3051707 TK.Half.Life NA 0.6102 hours 1compartment NA NA Human Human -DTXSID3051707 Css NA 0.01684 mg/L 3compartmentss NA 50% Human Human -DTXSID3051707 Css NA 0.1829 mg/L 3compartmentss NA 95% Human Human -DTXSID3051707 Css NA 0.01364 mg/L PBTK NA 50% Human Human -DTXSID3051707 Css NA 0.1264 mg/L PBTK NA 95% Human Human +DTXSID3051707 TK.Half.Life NA 0.6048 hours 1compartment NA NA Human Human +DTXSID3051707 Css NA 0.0108 mg/L 3compartmentss NA 50% Human Human +DTXSID3051707 Css NA 0.1581 mg/L 3compartmentss NA 95% Human Human +DTXSID3051707 Css NA 0.008749 mg/L PBTK NA 50% Human Human +DTXSID3051707 Css NA 0.1088 mg/L PBTK NA 95% Human Human DTXSID3051707 Clint NA 44.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID3051707 Fup NA 0.6353 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3051707 Vd NA 0.8037 L/kg 1compartment NA NA Rat Human +DTXSID3051707 Vd NA 0.7971 L/kg 1compartment NA NA Rat Human DTXSID3051707 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3051707 TK.Half.Life NA 0.2817 hours 1compartment NA NA Rat Human -DTXSID3051707 Css NA 0.008562 mg/L 3compartmentss NA 50% Rat Human -DTXSID3051707 Css NA 0.08734 mg/L 3compartmentss NA 95% Rat Human -DTXSID3051707 Css NA 0.006835 mg/L PBTK NA 50% Rat Human -DTXSID3051707 Css NA 0.05731 mg/L PBTK NA 95% Rat Human -DTXSID3051834 Clint NA 95.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3051834 Fup NA 0.0395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3051834 Vd NA 3.056 L/kg 1compartment NA NA Human Human -DTXSID3051834 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3051834 TK.Half.Life NA 14.86 hours 1compartment NA NA Human Human -DTXSID3051834 Css NA 0.5209 mg/L 3compartmentss NA 50% Human Human -DTXSID3051834 Css NA 3.386 mg/L 3compartmentss NA 95% Human Human -DTXSID3051834 Css NA 0.3607 mg/L PBTK NA 50% Human Human -DTXSID3051834 Css NA 2.261 mg/L PBTK NA 95% Human Human -DTXSID3051834 Clint NA 95.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3051834 Fup NA 0.0395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3051834 Vd NA 2.29 L/kg 1compartment NA NA Rat Human -DTXSID3051834 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3051834 TK.Half.Life NA 2.58 hours 1compartment NA NA Rat Human -DTXSID3051834 Css NA 0.2924 mg/L 3compartmentss NA 50% Rat Human -DTXSID3051834 Css NA 1.571 mg/L 3compartmentss NA 95% Rat Human -DTXSID3051834 Css NA 0.1931 mg/L PBTK NA 50% Rat Human -DTXSID3051834 Css NA 0.9934 mg/L PBTK NA 95% Rat Human -DTXSID3051836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3051836 Fup NA 0.7836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3051836 Vd NA 0.8984 L/kg 1compartment NA NA Human Human +DTXSID3051707 TK.Half.Life NA 0.2796 hours 1compartment NA NA Rat Human +DTXSID3051707 Css NA 0.0003844 mg/L 3compartmentss NA 50% Rat Human +DTXSID3051707 Css NA 0.006051 mg/L 3compartmentss NA 95% Rat Human +DTXSID3051707 Css NA 0.0003085 mg/L PBTK NA 50% Rat Human +DTXSID3051707 Css NA 0.004028 mg/L PBTK NA 95% Rat Human +DTXSID3051834 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3051834 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3051834 Vd NA 3.098 L/kg 1compartment NA NA Human Human +DTXSID3051834 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID3051834 TK.Half.Life NA 81.06 hours 1compartment NA NA Human Human +DTXSID3051834 Css NA 3.138 mg/L 3compartmentss NA 50% Human Human +DTXSID3051834 Css NA 19.91 mg/L 3compartmentss NA 95% Human Human +DTXSID3051834 Css NA 2.171 mg/L PBTK NA 50% Human Human +DTXSID3051834 Css NA 13.49 mg/L PBTK NA 95% Human Human +DTXSID3051834 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3051834 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3051834 Vd NA 2.321 L/kg 1compartment NA NA Rat Human +DTXSID3051834 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID3051834 TK.Half.Life NA 11.29 hours 1compartment NA NA Rat Human +DTXSID3051834 Css NA 0.4048 mg/L 3compartmentss NA 50% Rat Human +DTXSID3051834 Css NA 2.201 mg/L 3compartmentss NA 95% Rat Human +DTXSID3051834 Css NA 0.2765 mg/L PBTK NA 50% Rat Human +DTXSID3051834 Css NA 1.453 mg/L PBTK NA 95% Rat Human +DTXSID3051836 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3051836 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3051836 Vd NA 0.6374 L/kg 1compartment NA NA Human Human DTXSID3051836 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3051836 TK.Half.Life NA 7.511 hours 1compartment NA NA Human Human -DTXSID3051836 Css NA 0.9734 mg/L 3compartmentss NA 50% Human Human -DTXSID3051836 Css NA 6.022 mg/L 3compartmentss NA 95% Human Human -DTXSID3051836 Css NA 0.8312 mg/L PBTK NA 50% Human Human -DTXSID3051836 Css NA 3.999 mg/L PBTK NA 95% Human Human -DTXSID3051836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3051836 Fup NA 0.7836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3051836 Vd NA 0.8921 L/kg 1compartment NA NA Rat Human +DTXSID3051836 TK.Half.Life NA 6.348 hours 1compartment NA NA Human Human +DTXSID3051836 Css NA 0.9938 mg/L 3compartmentss NA 50% Human Human +DTXSID3051836 Css NA 6.541 mg/L 3compartmentss NA 95% Human Human +DTXSID3051836 Css NA 0.7891 mg/L PBTK NA 50% Human Human +DTXSID3051836 Css NA 4.085 mg/L PBTK NA 95% Human Human +DTXSID3051836 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3051836 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3051836 Vd NA 0.6603 L/kg 1compartment NA NA Rat Human DTXSID3051836 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3051836 TK.Half.Life NA 2.518 hours 1compartment NA NA Rat Human -DTXSID3051836 Css NA 0.2473 mg/L 3compartmentss NA 50% Rat Human -DTXSID3051836 Css NA 1.576 mg/L 3compartmentss NA 95% Rat Human -DTXSID3051836 Css NA 0.2055 mg/L PBTK NA 50% Rat Human -DTXSID3051836 Css NA 0.9501 mg/L PBTK NA 95% Rat Human -DTXSID3052278 Clint NA 1.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3052278 Fup NA 0.5288 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3052278 Vd NA 0.7825 L/kg 1compartment NA NA Human Human +DTXSID3051836 TK.Half.Life NA 2.24 hours 1compartment NA NA Rat Human +DTXSID3051836 Css NA 0.01894 mg/L 3compartmentss NA 50% Rat Human +DTXSID3051836 Css NA 0.1519 mg/L 3compartmentss NA 95% Rat Human +DTXSID3051836 Css NA 0.01451 mg/L PBTK NA 50% Rat Human +DTXSID3051836 Css NA 0.09642 mg/L PBTK NA 95% Rat Human +DTXSID3051888 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3051888 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3051888 Vd NA 1.018 L/kg 1compartment NA NA Human Human +DTXSID3051888 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3051888 TK.Half.Life NA 9.87 hours 1compartment NA NA Human Human +DTXSID3051888 Css NA 0.8912 mg/L 3compartmentss NA 50% Human Human +DTXSID3051888 Css NA 6.297 mg/L 3compartmentss NA 95% Human Human +DTXSID3051888 Css NA 0.7685 mg/L PBTK NA 50% Human Human +DTXSID3051888 Css NA 4.073 mg/L PBTK NA 95% Human Human +DTXSID3051888 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3051888 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3051888 Vd NA 0.9666 L/kg 1compartment NA NA Rat Human +DTXSID3051888 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3051888 TK.Half.Life NA 3.111 hours 1compartment NA NA Rat Human +DTXSID3051888 Css NA 0.01692 mg/L 3compartmentss NA 50% Rat Human +DTXSID3051888 Css NA 0.1423 mg/L 3compartmentss NA 95% Rat Human +DTXSID3051888 Css NA 0.01402 mg/L PBTK NA 50% Rat Human +DTXSID3051888 Css NA 0.09286 mg/L PBTK NA 95% Rat Human +DTXSID3052060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052060 Fup 0.873 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052060 Vd NA 1.015 L/kg 1compartment NA NA Human Human +DTXSID3052060 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3052060 TK.Half.Life NA 0.7355 hours 1compartment NA NA Human Human +DTXSID3052060 Css NA 0.01876 mg/L 3compartmentss NA 50% Human Human +DTXSID3052060 Css NA 0.2252 mg/L 3compartmentss NA 95% Human Human +DTXSID3052060 Css NA 0.01622 mg/L PBTK NA 50% Human Human +DTXSID3052060 Css NA 0.1633 mg/L PBTK NA 95% Human Human +DTXSID3052060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052060 Fup 0.873 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052060 Vd NA 0.9969 L/kg 1compartment NA NA Rat Human +DTXSID3052060 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3052060 TK.Half.Life NA 0.348 hours 1compartment NA NA Rat Human +DTXSID3052060 Css NA 0.000662 mg/L 3compartmentss NA 50% Rat Human +DTXSID3052060 Css NA 0.008387 mg/L 3compartmentss NA 95% Rat Human +DTXSID3052060 Css NA 0.0005693 mg/L PBTK NA 50% Rat Human +DTXSID3052060 Css NA 0.00613 mg/L PBTK NA 95% Rat Human +DTXSID3052143 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052143 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052143 Vd NA 2.602 L/kg 1compartment NA NA Human Human +DTXSID3052143 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3052143 TK.Half.Life NA 6.601 hours 1compartment NA NA Human Human +DTXSID3052143 Css NA 0.2102 mg/L 3compartmentss NA 50% Human Human +DTXSID3052143 Css NA 1.333 mg/L 3compartmentss NA 95% Human Human +DTXSID3052143 Css NA 0.154 mg/L PBTK NA 50% Human Human +DTXSID3052143 Css NA 0.9334 mg/L PBTK NA 95% Human Human +DTXSID3052143 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052143 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052143 Vd NA 1.985 L/kg 1compartment NA NA Rat Human +DTXSID3052143 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3052143 TK.Half.Life NA 1.757 hours 1compartment NA NA Rat Human +DTXSID3052143 Css NA 0.02632 mg/L 3compartmentss NA 50% Rat Human +DTXSID3052143 Css NA 0.1295 mg/L 3compartmentss NA 95% Rat Human +DTXSID3052143 Css NA 0.01928 mg/L PBTK NA 50% Rat Human +DTXSID3052143 Css NA 0.09105 mg/L PBTK NA 95% Rat Human +DTXSID3052278 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052278 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052278 Vd NA 0.6185 L/kg 1compartment NA NA Human Human DTXSID3052278 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3052278 TK.Half.Life NA 3.202 hours 1compartment NA NA Human Human -DTXSID3052278 Css NA 0.4132 mg/L 3compartmentss NA 50% Human Human -DTXSID3052278 Css NA 2.712 mg/L 3compartmentss NA 95% Human Human -DTXSID3052278 Css NA 0.3316 mg/L PBTK NA 50% Human Human -DTXSID3052278 Css NA 1.741 mg/L PBTK NA 95% Human Human -DTXSID3052278 Clint NA 1.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3052278 Fup NA 0.5288 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3052278 Vd NA 0.7569 L/kg 1compartment NA NA Rat Human +DTXSID3052278 TK.Half.Life NA 1.393 hours 1compartment NA NA Human Human +DTXSID3052278 Css NA 0.1881 mg/L 3compartmentss NA 50% Human Human +DTXSID3052278 Css NA 1.204 mg/L 3compartmentss NA 95% Human Human +DTXSID3052278 Css NA 0.1363 mg/L PBTK NA 50% Human Human +DTXSID3052278 Css NA 0.7917 mg/L PBTK NA 95% Human Human +DTXSID3052278 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052278 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052278 Vd NA 0.5962 L/kg 1compartment NA NA Rat Human DTXSID3052278 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3052278 TK.Half.Life NA 1.558 hours 1compartment NA NA Rat Human -DTXSID3052278 Css NA 0.1745 mg/L 3compartmentss NA 50% Rat Human -DTXSID3052278 Css NA 0.9989 mg/L 3compartmentss NA 95% Rat Human -DTXSID3052278 Css NA 0.1345 mg/L PBTK NA 50% Rat Human -DTXSID3052278 Css NA 0.5981 mg/L PBTK NA 95% Rat Human -DTXSID3052301 Clint NA 10.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3052301 Fup NA 0.8504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3052301 Vd NA 1.291 L/kg 1compartment NA NA Human Human +DTXSID3052278 TK.Half.Life NA 0.7545 hours 1compartment NA NA Rat Human +DTXSID3052278 Css NA 0.02199 mg/L 3compartmentss NA 50% Rat Human +DTXSID3052278 Css NA 0.1077 mg/L 3compartmentss NA 95% Rat Human +DTXSID3052278 Css NA 0.01591 mg/L PBTK NA 50% Rat Human +DTXSID3052278 Css NA 0.06863 mg/L PBTK NA 95% Rat Human +DTXSID3052301 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052301 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052301 Vd NA 1.061 L/kg 1compartment NA NA Human Human DTXSID3052301 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3052301 TK.Half.Life NA 1.195 hours 1compartment NA NA Human Human -DTXSID3052301 Css NA 0.05185 mg/L 3compartmentss NA 50% Human Human -DTXSID3052301 Css NA 0.5014 mg/L 3compartmentss NA 95% Human Human -DTXSID3052301 Css NA 0.04675 mg/L PBTK NA 50% Human Human -DTXSID3052301 Css NA 0.3651 mg/L PBTK NA 95% Human Human -DTXSID3052301 Clint NA 10.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3052301 Fup NA 0.8504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3052301 Vd NA 1.199 L/kg 1compartment NA NA Rat Human +DTXSID3052301 TK.Half.Life NA 0.9887 hours 1compartment NA NA Human Human +DTXSID3052301 Css NA 0.02821 mg/L 3compartmentss NA 50% Human Human +DTXSID3052301 Css NA 0.3119 mg/L 3compartmentss NA 95% Human Human +DTXSID3052301 Css NA 0.02318 mg/L PBTK NA 50% Human Human +DTXSID3052301 Css NA 0.2209 mg/L PBTK NA 95% Human Human +DTXSID3052301 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052301 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052301 Vd NA 0.9684 L/kg 1compartment NA NA Rat Human DTXSID3052301 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3052301 TK.Half.Life NA 0.5576 hours 1compartment NA NA Rat Human -DTXSID3052301 Css NA 0.02566 mg/L 3compartmentss NA 50% Rat Human -DTXSID3052301 Css NA 0.1972 mg/L 3compartmentss NA 95% Rat Human -DTXSID3052301 Css NA 0.02276 mg/L PBTK NA 50% Rat Human -DTXSID3052301 Css NA 0.1341 mg/L PBTK NA 95% Rat Human -DTXSID3052511 Clint NA 7.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3052511 Fup NA 0.02 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3052511 Vd NA 3.064 L/kg 1compartment NA NA Human Human -DTXSID3052511 Days.Css NA 43 Days PBTK NA NA Human Human -DTXSID3052511 TK.Half.Life NA 212.4 hours 1compartment NA NA Human Human -DTXSID3052511 Css NA 8.799 mg/L 3compartmentss NA 50% Human Human -DTXSID3052511 Css NA 55.46 mg/L 3compartmentss NA 95% Human Human -DTXSID3052511 Css NA 6.098 mg/L PBTK NA 50% Human Human -DTXSID3052511 Css NA 37.02 mg/L PBTK NA 95% Human Human -DTXSID3052511 Clint NA 7.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3052511 Fup NA 0.02 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3052511 Vd NA 2.294 L/kg 1compartment NA NA Rat Human -DTXSID3052511 Days.Css NA 24 Days PBTK NA NA Rat Human -DTXSID3052511 TK.Half.Life NA 29.98 hours 1compartment NA NA Rat Human -DTXSID3052511 Css NA 4.913 mg/L 3compartmentss NA 50% Rat Human -DTXSID3052511 Css NA 25.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID3052511 Css NA 3.237 mg/L PBTK NA 50% Rat Human -DTXSID3052511 Css NA 16.12 mg/L PBTK NA 95% Rat Human -DTXSID3052567 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3052567 Fup NA 0.5936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3052567 Vd NA 2.781 L/kg 1compartment NA NA Human Human -DTXSID3052567 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID3052567 TK.Half.Life NA 30.56 hours 1compartment NA NA Human Human -DTXSID3052567 Css NA 0.9033 mg/L 3compartmentss NA 50% Human Human -DTXSID3052567 Css NA 7.726 mg/L 3compartmentss NA 95% Human Human -DTXSID3052567 Css NA 1.005 mg/L PBTK NA 50% Human Human -DTXSID3052567 Css NA 5.43 mg/L PBTK NA 95% Human Human -DTXSID3052567 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3052567 Fup NA 0.5936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3052567 Vd NA 2.823 L/kg 1compartment NA NA Rat Human +DTXSID3052301 TK.Half.Life NA 0.4472 hours 1compartment NA NA Rat Human +DTXSID3052301 Css NA 0.001 mg/L 3compartmentss NA 50% Rat Human +DTXSID3052301 Css NA 0.01307 mg/L 3compartmentss NA 95% Rat Human +DTXSID3052301 Css NA 0.0008144 mg/L PBTK NA 50% Rat Human +DTXSID3052301 Css NA 0.008847 mg/L PBTK NA 95% Rat Human +DTXSID3052309 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052309 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052309 Vd NA 1.016 L/kg 1compartment NA NA Human Human +DTXSID3052309 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3052309 TK.Half.Life NA 1.964 hours 1compartment NA NA Human Human +DTXSID3052309 Css NA 0.1256 mg/L 3compartmentss NA 50% Human Human +DTXSID3052309 Css NA 0.9044 mg/L 3compartmentss NA 95% Human Human +DTXSID3052309 Css NA 0.09944 mg/L PBTK NA 50% Human Human +DTXSID3052309 Css NA 0.6127 mg/L PBTK NA 95% Human Human +DTXSID3052309 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052309 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052309 Vd NA 0.9078 L/kg 1compartment NA NA Rat Human +DTXSID3052309 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3052309 TK.Half.Life NA 0.9477 hours 1compartment NA NA Rat Human +DTXSID3052309 Css NA 0.004158 mg/L 3compartmentss NA 50% Rat Human +DTXSID3052309 Css NA 0.03593 mg/L 3compartmentss NA 95% Rat Human +DTXSID3052309 Css NA 0.00322 mg/L PBTK NA 50% Rat Human +DTXSID3052309 Css NA 0.02398 mg/L PBTK NA 95% Rat Human +DTXSID3052511 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052511 Fup 0.00562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052511 Vd NA 2.886 L/kg 1compartment NA NA Human Human +DTXSID3052511 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID3052511 TK.Half.Life NA 74.17 hours 1compartment NA NA Human Human +DTXSID3052511 Css NA 3.341 mg/L 3compartmentss NA 50% Human Human +DTXSID3052511 Css NA 23.46 mg/L 3compartmentss NA 95% Human Human +DTXSID3052511 Css NA 2.258 mg/L PBTK NA 50% Human Human +DTXSID3052511 Css NA 15.13 mg/L PBTK NA 95% Human Human +DTXSID3052511 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052511 Fup 0.00562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052511 Vd NA 2.156 L/kg 1compartment NA NA Rat Human +DTXSID3052511 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID3052511 TK.Half.Life NA 13.19 hours 1compartment NA NA Rat Human +DTXSID3052511 Css NA 0.439 mg/L 3compartmentss NA 50% Rat Human +DTXSID3052511 Css NA 2.613 mg/L 3compartmentss NA 95% Rat Human +DTXSID3052511 Css NA 0.2922 mg/L PBTK NA 50% Rat Human +DTXSID3052511 Css NA 1.676 mg/L PBTK NA 95% Rat Human +DTXSID3052567 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052567 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052567 Vd NA 2.703 L/kg 1compartment NA NA Human Human +DTXSID3052567 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID3052567 TK.Half.Life NA 31.49 hours 1compartment NA NA Human Human +DTXSID3052567 Css NA 0.9178 mg/L 3compartmentss NA 50% Human Human +DTXSID3052567 Css NA 8.109 mg/L 3compartmentss NA 95% Human Human +DTXSID3052567 Css NA 1.007 mg/L PBTK NA 50% Human Human +DTXSID3052567 Css NA 5.625 mg/L PBTK NA 95% Human Human +DTXSID3052567 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052567 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052567 Vd NA 2.742 L/kg 1compartment NA NA Rat Human DTXSID3052567 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3052567 TK.Half.Life NA 10.51 hours 1compartment NA NA Rat Human -DTXSID3052567 Css NA 0.2302 mg/L 3compartmentss NA 50% Rat Human -DTXSID3052567 Css NA 1.81 mg/L 3compartmentss NA 95% Rat Human -DTXSID3052567 Css NA 0.2539 mg/L PBTK NA 50% Rat Human -DTXSID3052567 Css NA 1.194 mg/L PBTK NA 95% Rat Human -DTXSID3057640 Clint NA 296.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057640 Fup NA 0.0942 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057640 Vd NA 0.8535 L/kg 1compartment NA NA Human Human +DTXSID3052567 TK.Half.Life NA 10.82 hours 1compartment NA NA Rat Human +DTXSID3052567 Css NA 0.05427 mg/L 3compartmentss NA 50% Rat Human +DTXSID3052567 Css NA 0.459 mg/L 3compartmentss NA 95% Rat Human +DTXSID3052567 Css NA 0.0613 mg/L PBTK NA 50% Rat Human +DTXSID3052567 Css NA 0.3089 mg/L PBTK NA 95% Rat Human +DTXSID3052696 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052696 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3052696 Vd NA 0.4158 L/kg 1compartment NA NA Human Human +DTXSID3052696 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3052696 TK.Half.Life NA 0.5668 hours 1compartment NA NA Human Human +DTXSID3052696 Css NA 0.07291 mg/L 3compartmentss NA 50% Human Human +DTXSID3052696 Css NA 0.5363 mg/L 3compartmentss NA 95% Human Human +DTXSID3052696 Css NA 0.04984 mg/L PBTK NA 50% Human Human +DTXSID3052696 Css NA 0.3438 mg/L PBTK NA 95% Human Human +DTXSID3052696 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052696 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3052696 Vd NA 0.4094 L/kg 1compartment NA NA Rat Human +DTXSID3052696 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3052696 TK.Half.Life NA 0.2965 hours 1compartment NA NA Rat Human +DTXSID3052696 Css NA 0.00913 mg/L 3compartmentss NA 50% Rat Human +DTXSID3052696 Css NA 0.05236 mg/L 3compartmentss NA 95% Rat Human +DTXSID3052696 Css NA 0.00621 mg/L PBTK NA 50% Rat Human +DTXSID3052696 Css NA 0.03263 mg/L PBTK NA 95% Rat Human +DTXSID3057640 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057640 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057640 Vd NA 0.6989 L/kg 1compartment NA NA Human Human DTXSID3057640 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057640 TK.Half.Life NA 0.8505 hours 1compartment NA NA Human Human -DTXSID3057640 Css NA 0.02273 mg/L 3compartmentss NA 50% Human Human -DTXSID3057640 Css NA 0.2048 mg/L 3compartmentss NA 95% Human Human -DTXSID3057640 Css NA 0.01471 mg/L PBTK NA 50% Human Human -DTXSID3057640 Css NA 0.1253 mg/L PBTK NA 95% Human Human -DTXSID3057640 Clint NA 296.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057640 Fup NA 0.0942 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057640 Vd NA 0.7261 L/kg 1compartment NA NA Rat Human +DTXSID3057640 TK.Half.Life NA 1.925 hours 1compartment NA NA Human Human +DTXSID3057640 Css NA 0.2173 mg/L 3compartmentss NA 50% Human Human +DTXSID3057640 Css NA 1.363 mg/L 3compartmentss NA 95% Human Human +DTXSID3057640 Css NA 0.1546 mg/L PBTK NA 50% Human Human +DTXSID3057640 Css NA 0.8938 mg/L PBTK NA 95% Human Human +DTXSID3057640 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057640 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057640 Vd NA 0.6827 L/kg 1compartment NA NA Rat Human DTXSID3057640 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057640 TK.Half.Life NA 0.3385 hours 1compartment NA NA Rat Human -DTXSID3057640 Css NA 0.01324 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057640 Css NA 0.09175 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057640 Css NA 0.008027 mg/L PBTK NA 50% Rat Human -DTXSID3057640 Css NA 0.05266 mg/L PBTK NA 95% Rat Human -DTXSID3057642 Clint NA 50.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057642 Fup NA 0.1012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057642 Vd NA 1.268 L/kg 1compartment NA NA Human Human +DTXSID3057640 TK.Half.Life NA 1.082 hours 1compartment NA NA Rat Human +DTXSID3057640 Css NA 0.009355 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057640 Css NA 0.07262 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057640 Css NA 0.006585 mg/L PBTK NA 50% Rat Human +DTXSID3057640 Css NA 0.04572 mg/L PBTK NA 95% Rat Human +DTXSID3057642 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057642 Fup 0.0899 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057642 Vd NA 1.208 L/kg 1compartment NA NA Human Human DTXSID3057642 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057642 TK.Half.Life NA 2.092 hours 1compartment NA NA Human Human -DTXSID3057642 Css NA 0.1323 mg/L 3compartmentss NA 50% Human Human -DTXSID3057642 Css NA 1.038 mg/L 3compartmentss NA 95% Human Human -DTXSID3057642 Css NA 0.08744 mg/L PBTK NA 50% Human Human -DTXSID3057642 Css NA 0.6355 mg/L PBTK NA 95% Human Human -DTXSID3057642 Clint NA 50.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057642 Fup NA 0.1012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057642 Vd NA 0.9803 L/kg 1compartment NA NA Rat Human +DTXSID3057642 TK.Half.Life NA 3.511 hours 1compartment NA NA Human Human +DTXSID3057642 Css NA 0.3279 mg/L 3compartmentss NA 50% Human Human +DTXSID3057642 Css NA 2.576 mg/L 3compartmentss NA 95% Human Human +DTXSID3057642 Css NA 0.2134 mg/L PBTK NA 50% Human Human +DTXSID3057642 Css NA 1.583 mg/L PBTK NA 95% Human Human +DTXSID3057642 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057642 Fup 0.0899 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057642 Vd NA 0.9323 L/kg 1compartment NA NA Rat Human DTXSID3057642 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057642 TK.Half.Life NA 0.8208 hours 1compartment NA NA Rat Human -DTXSID3057642 Css NA 0.07309 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057642 Css NA 0.4694 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057642 Css NA 0.04546 mg/L PBTK NA 50% Rat Human -DTXSID3057642 Css NA 0.2731 mg/L PBTK NA 95% Rat Human -DTXSID3057644 Clint NA 33.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057644 Fup NA 0.0157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057644 Vd NA 0.9215 L/kg 1compartment NA NA Human Human +DTXSID3057642 TK.Half.Life NA 1.462 hours 1compartment NA NA Rat Human +DTXSID3057642 Css NA 0.04227 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057642 Css NA 0.2555 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057642 Css NA 0.02682 mg/L PBTK NA 50% Rat Human +DTXSID3057642 Css NA 0.1518 mg/L PBTK NA 95% Rat Human +DTXSID3057644 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057644 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057644 Vd NA 1.237 L/kg 1compartment NA NA Human Human DTXSID3057644 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057644 TK.Half.Life NA 6.776 hours 1compartment NA NA Human Human -DTXSID3057644 Css NA 1.201 mg/L 3compartmentss NA 50% Human Human -DTXSID3057644 Css NA 11.73 mg/L 3compartmentss NA 95% Human Human -DTXSID3057644 Css NA 0.7256 mg/L PBTK NA 50% Human Human -DTXSID3057644 Css NA 6.903 mg/L PBTK NA 95% Human Human -DTXSID3057644 Clint NA 33.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057644 Fup NA 0.0157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057644 Vd NA 0.6843 L/kg 1compartment NA NA Rat Human +DTXSID3057644 TK.Half.Life NA 7.398 hours 1compartment NA NA Human Human +DTXSID3057644 Css NA 0.8957 mg/L 3compartmentss NA 50% Human Human +DTXSID3057644 Css NA 6.854 mg/L 3compartmentss NA 95% Human Human +DTXSID3057644 Css NA 0.557 mg/L PBTK NA 50% Human Human +DTXSID3057644 Css NA 4.102 mg/L PBTK NA 95% Human Human +DTXSID3057644 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057644 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057644 Vd NA 0.9244 L/kg 1compartment NA NA Rat Human DTXSID3057644 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057644 TK.Half.Life NA 3.007 hours 1compartment NA NA Rat Human -DTXSID3057644 Css NA 0.675 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057644 Css NA 5.196 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057644 Css NA 0.3822 mg/L PBTK NA 50% Rat Human -DTXSID3057644 Css NA 2.868 mg/L PBTK NA 95% Rat Human -DTXSID3057646 Clint NA 0.5107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057646 Fup NA 0.5849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057646 Vd NA 1.042 L/kg 1compartment NA NA Human Human +DTXSID3057644 TK.Half.Life NA 3.049 hours 1compartment NA NA Rat Human +DTXSID3057644 Css NA 0.119 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057644 Css NA 0.6854 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057644 Css NA 0.07186 mg/L PBTK NA 50% Rat Human +DTXSID3057644 Css NA 0.4037 mg/L PBTK NA 95% Rat Human +DTXSID3057646 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057646 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057646 Vd NA 0.7369 L/kg 1compartment NA NA Human Human DTXSID3057646 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057646 TK.Half.Life NA 6.678 hours 1compartment NA NA Human Human -DTXSID3057646 Css NA 0.658 mg/L 3compartmentss NA 50% Human Human -DTXSID3057646 Css NA 4.609 mg/L 3compartmentss NA 95% Human Human -DTXSID3057646 Css NA 0.5522 mg/L PBTK NA 50% Human Human -DTXSID3057646 Css NA 2.916 mg/L PBTK NA 95% Human Human -DTXSID3057646 Clint NA 0.5107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057646 Fup NA 0.5849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057646 Vd NA 0.9565 L/kg 1compartment NA NA Rat Human +DTXSID3057646 TK.Half.Life NA 1.802 hours 1compartment NA NA Human Human +DTXSID3057646 Css NA 0.21 mg/L 3compartmentss NA 50% Human Human +DTXSID3057646 Css NA 1.347 mg/L 3compartmentss NA 95% Human Human +DTXSID3057646 Css NA 0.1527 mg/L PBTK NA 50% Human Human +DTXSID3057646 Css NA 0.8871 mg/L PBTK NA 95% Human Human +DTXSID3057646 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057646 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057646 Vd NA 0.6721 L/kg 1compartment NA NA Rat Human DTXSID3057646 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057646 TK.Half.Life NA 2.598 hours 1compartment NA NA Rat Human -DTXSID3057646 Css NA 0.2311 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057646 Css NA 1.573 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057646 Css NA 0.1874 mg/L PBTK NA 50% Rat Human -DTXSID3057646 Css NA 0.9298 mg/L PBTK NA 95% Rat Human -DTXSID3057648 Clint NA 42.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057648 Fup NA 0.0348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057648 Vd NA 1.212 L/kg 1compartment NA NA Human Human +DTXSID3057646 TK.Half.Life NA 0.9224 hours 1compartment NA NA Rat Human +DTXSID3057646 Css NA 0.02468 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057646 Css NA 0.1153 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057646 Css NA 0.01778 mg/L PBTK NA 50% Rat Human +DTXSID3057646 Css NA 0.07386 mg/L PBTK NA 95% Rat Human +DTXSID3057648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057648 Fup 0.0282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057648 Vd NA 1.134 L/kg 1compartment NA NA Human Human DTXSID3057648 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057648 TK.Half.Life NA 3.02 hours 1compartment NA NA Human Human -DTXSID3057648 Css NA 0.2926 mg/L 3compartmentss NA 50% Human Human -DTXSID3057648 Css NA 2.411 mg/L 3compartmentss NA 95% Human Human -DTXSID3057648 Css NA 0.1967 mg/L PBTK NA 50% Human Human -DTXSID3057648 Css NA 1.529 mg/L PBTK NA 95% Human Human -DTXSID3057648 Clint NA 42.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057648 Fup NA 0.0348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057648 Vd NA 1.178 L/kg 1compartment NA NA Rat Human +DTXSID3057648 TK.Half.Life NA 5.196 hours 1compartment NA NA Human Human +DTXSID3057648 Css NA 0.6265 mg/L 3compartmentss NA 50% Human Human +DTXSID3057648 Css NA 6.45 mg/L 3compartmentss NA 95% Human Human +DTXSID3057648 Css NA 0.4186 mg/L PBTK NA 50% Human Human +DTXSID3057648 Css NA 4.003 mg/L PBTK NA 95% Human Human +DTXSID3057648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057648 Fup 0.0282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057648 Vd NA 1.096 L/kg 1compartment NA NA Rat Human DTXSID3057648 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057648 TK.Half.Life NA 1.778 hours 1compartment NA NA Rat Human -DTXSID3057648 Css NA 0.1672 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057648 Css NA 1.168 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057648 Css NA 0.1062 mg/L PBTK NA 50% Rat Human -DTXSID3057648 Css NA 0.6893 mg/L PBTK NA 95% Rat Human -DTXSID3057690 Clint NA 16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057690 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057690 Vd NA 0.8285 L/kg 1compartment NA NA Human Human +DTXSID3057648 TK.Half.Life NA 3.194 hours 1compartment NA NA Rat Human +DTXSID3057648 Css NA 0.08298 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057648 Css NA 0.7398 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057648 Css NA 0.05378 mg/L PBTK NA 50% Rat Human +DTXSID3057648 Css NA 0.4373 mg/L PBTK NA 95% Rat Human +DTXSID3057690 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057690 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057690 Vd NA 1.296 L/kg 1compartment NA NA Human Human DTXSID3057690 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057690 TK.Half.Life NA 4.343 hours 1compartment NA NA Human Human -DTXSID3057690 Css NA 0.7676 mg/L 3compartmentss NA 50% Human Human -DTXSID3057690 Css NA 6.202 mg/L 3compartmentss NA 95% Human Human -DTXSID3057690 Css NA 0.4788 mg/L PBTK NA 50% Human Human -DTXSID3057690 Css NA 3.764 mg/L PBTK NA 95% Human Human -DTXSID3057690 Clint NA 16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057690 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057690 Vd NA 0.6353 L/kg 1compartment NA NA Rat Human +DTXSID3057690 TK.Half.Life NA 7.812 hours 1compartment NA NA Human Human +DTXSID3057690 Css NA 0.7788 mg/L 3compartmentss NA 50% Human Human +DTXSID3057690 Css NA 5.078 mg/L 3compartmentss NA 95% Human Human +DTXSID3057690 Css NA 0.521 mg/L PBTK NA 50% Human Human +DTXSID3057690 Css NA 3.202 mg/L PBTK NA 95% Human Human +DTXSID3057690 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057690 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057690 Vd NA 0.9967 L/kg 1compartment NA NA Rat Human DTXSID3057690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057690 TK.Half.Life NA 1.971 hours 1compartment NA NA Rat Human -DTXSID3057690 Css NA 0.4326 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057690 Css NA 2.589 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057690 Css NA 0.2522 mg/L PBTK NA 50% Rat Human -DTXSID3057690 Css NA 1.442 mg/L PBTK NA 95% Rat Human -DTXSID3057692 Clint NA 22.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057692 Fup NA 0.158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057692 Vd NA 2.091 L/kg 1compartment NA NA Human Human +DTXSID3057690 TK.Half.Life NA 3.138 hours 1compartment NA NA Rat Human +DTXSID3057690 Css NA 0.09474 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057690 Css NA 0.4671 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057690 Css NA 0.06238 mg/L PBTK NA 50% Rat Human +DTXSID3057690 Css NA 0.2806 mg/L PBTK NA 95% Rat Human +DTXSID3057692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057692 Fup 0.0755 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057692 Vd NA 1.89 L/kg 1compartment NA NA Human Human DTXSID3057692 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057692 TK.Half.Life NA 5.026 hours 1compartment NA NA Human Human -DTXSID3057692 Css NA 0.2228 mg/L 3compartmentss NA 50% Human Human -DTXSID3057692 Css NA 1.476 mg/L 3compartmentss NA 95% Human Human -DTXSID3057692 Css NA 0.157 mg/L PBTK NA 50% Human Human -DTXSID3057692 Css NA 0.9831 mg/L PBTK NA 95% Human Human -DTXSID3057692 Clint NA 22.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057692 Fup NA 0.158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057692 Vd NA 1.598 L/kg 1compartment NA NA Rat Human +DTXSID3057692 TK.Half.Life NA 7.335 hours 1compartment NA NA Human Human +DTXSID3057692 Css NA 0.4561 mg/L 3compartmentss NA 50% Human Human +DTXSID3057692 Css NA 3.35 mg/L 3compartmentss NA 95% Human Human +DTXSID3057692 Css NA 0.3022 mg/L PBTK NA 50% Human Human +DTXSID3057692 Css NA 2.125 mg/L PBTK NA 95% Human Human +DTXSID3057692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057692 Fup 0.0755 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057692 Vd NA 1.426 L/kg 1compartment NA NA Rat Human DTXSID3057692 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057692 TK.Half.Life NA 1.645 hours 1compartment NA NA Rat Human -DTXSID3057692 Css NA 0.1218 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057692 Css NA 0.6353 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057692 Css NA 0.08189 mg/L PBTK NA 50% Rat Human -DTXSID3057692 Css NA 0.4038 mg/L PBTK NA 95% Rat Human -DTXSID3057694 Clint NA 112.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057694 Fup NA 0.1417 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057694 Vd NA 0.3005 L/kg 1compartment NA NA Human Human +DTXSID3057692 TK.Half.Life NA 2.515 hours 1compartment NA NA Rat Human +DTXSID3057692 Css NA 0.0597 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057692 Css NA 0.3264 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057692 Css NA 0.03879 mg/L PBTK NA 50% Rat Human +DTXSID3057692 Css NA 0.2036 mg/L PBTK NA 95% Rat Human +DTXSID3057694 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057694 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057694 Vd NA 0.5382 L/kg 1compartment NA NA Human Human DTXSID3057694 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057694 TK.Half.Life NA 0.3401 hours 1compartment NA NA Human Human -DTXSID3057694 Css NA 0.03938 mg/L 3compartmentss NA 50% Human Human -DTXSID3057694 Css NA 0.3303 mg/L 3compartmentss NA 95% Human Human -DTXSID3057694 Css NA 0.02445 mg/L PBTK NA 50% Human Human -DTXSID3057694 Css NA 0.2001 mg/L PBTK NA 95% Human Human -DTXSID3057694 Clint NA 112.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057694 Fup NA 0.1417 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057694 Vd NA 0.2984 L/kg 1compartment NA NA Rat Human +DTXSID3057694 TK.Half.Life NA 1.358 hours 1compartment NA NA Human Human +DTXSID3057694 Css NA 0.2228 mg/L 3compartmentss NA 50% Human Human +DTXSID3057694 Css NA 1.413 mg/L 3compartmentss NA 95% Human Human +DTXSID3057694 Css NA 0.1554 mg/L PBTK NA 50% Human Human +DTXSID3057694 Css NA 0.91 mg/L PBTK NA 95% Human Human +DTXSID3057694 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057694 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057694 Vd NA 0.5106 L/kg 1compartment NA NA Rat Human DTXSID3057694 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057694 TK.Half.Life NA 0.1651 hours 1compartment NA NA Rat Human -DTXSID3057694 Css NA 0.02268 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057694 Css NA 0.1594 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057694 Css NA 0.0132 mg/L PBTK NA 50% Rat Human -DTXSID3057694 Css NA 0.09023 mg/L PBTK NA 95% Rat Human -DTXSID3057696 Clint NA 7.273 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057696 Fup NA 0.3388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057696 Vd NA 1.166 L/kg 1compartment NA NA Human Human +DTXSID3057694 TK.Half.Life NA 0.7299 hours 1compartment NA NA Rat Human +DTXSID3057694 Css NA 0.02647 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057694 Css NA 0.1208 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057694 Css NA 0.01818 mg/L PBTK NA 50% Rat Human +DTXSID3057694 Css NA 0.07528 mg/L PBTK NA 95% Rat Human +DTXSID3057696 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057696 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057696 Vd NA 1.204 L/kg 1compartment NA NA Human Human DTXSID3057696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057696 TK.Half.Life NA 2.556 hours 1compartment NA NA Human Human -DTXSID3057696 Css NA 0.1818 mg/L 3compartmentss NA 50% Human Human -DTXSID3057696 Css NA 1.14 mg/L 3compartmentss NA 95% Human Human -DTXSID3057696 Css NA 0.139 mg/L PBTK NA 50% Human Human -DTXSID3057696 Css NA 0.7856 mg/L PBTK NA 95% Human Human -DTXSID3057696 Clint NA 7.273 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057696 Fup NA 0.3388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057696 Vd NA 0.9878 L/kg 1compartment NA NA Rat Human +DTXSID3057696 TK.Half.Life NA 1.475 hours 1compartment NA NA Human Human +DTXSID3057696 Css NA 0.06049 mg/L 3compartmentss NA 50% Human Human +DTXSID3057696 Css NA 0.4638 mg/L 3compartmentss NA 95% Human Human +DTXSID3057696 Css NA 0.04638 mg/L PBTK NA 50% Human Human +DTXSID3057696 Css NA 0.3222 mg/L PBTK NA 95% Human Human +DTXSID3057696 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057696 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057696 Vd NA 1.016 L/kg 1compartment NA NA Rat Human DTXSID3057696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057696 TK.Half.Life NA 1.154 hours 1compartment NA NA Rat Human -DTXSID3057696 Css NA 0.09305 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057696 Css NA 0.4414 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057696 Css NA 0.06823 mg/L PBTK NA 50% Rat Human -DTXSID3057696 Css NA 0.2834 mg/L PBTK NA 95% Rat Human -DTXSID3057698 Clint NA 0.03265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057698 Fup NA 0.758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057698 Vd NA 1.626 L/kg 1compartment NA NA Human Human +DTXSID3057696 TK.Half.Life NA 0.6279 hours 1compartment NA NA Rat Human +DTXSID3057696 Css NA 0.007532 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057696 Css NA 0.04363 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057696 Css NA 0.005754 mg/L PBTK NA 50% Rat Human +DTXSID3057696 Css NA 0.03069 mg/L PBTK NA 95% Rat Human +DTXSID3057698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057698 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057698 Vd NA 1.512 L/kg 1compartment NA NA Human Human DTXSID3057698 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3057698 TK.Half.Life NA 13.17 hours 1compartment NA NA Human Human -DTXSID3057698 Css NA 0.8133 mg/L 3compartmentss NA 50% Human Human -DTXSID3057698 Css NA 5.399 mg/L 3compartmentss NA 95% Human Human -DTXSID3057698 Css NA 0.7912 mg/L PBTK NA 50% Human Human -DTXSID3057698 Css NA 3.664 mg/L PBTK NA 95% Human Human -DTXSID3057698 Clint NA 0.03265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057698 Fup NA 0.758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057698 Vd NA 1.612 L/kg 1compartment NA NA Rat Human +DTXSID3057698 TK.Half.Life NA 14.14 hours 1compartment NA NA Human Human +DTXSID3057698 Css NA 0.918 mg/L 3compartmentss NA 50% Human Human +DTXSID3057698 Css NA 6.557 mg/L 3compartmentss NA 95% Human Human +DTXSID3057698 Css NA 0.8705 mg/L PBTK NA 50% Human Human +DTXSID3057698 Css NA 4.423 mg/L PBTK NA 95% Human Human +DTXSID3057698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057698 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057698 Vd NA 1.497 L/kg 1compartment NA NA Rat Human DTXSID3057698 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057698 TK.Half.Life NA 4.569 hours 1compartment NA NA Rat Human -DTXSID3057698 Css NA 0.2134 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057698 Css NA 1.532 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057698 Css NA 0.2032 mg/L PBTK NA 50% Rat Human -DTXSID3057698 Css NA 0.9617 mg/L PBTK NA 95% Rat Human -DTXSID3057723 Clint NA 21.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID3057698 TK.Half.Life NA 4.767 hours 1compartment NA NA Rat Human +DTXSID3057698 Css NA 0.05384 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057698 Css NA 0.3833 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057698 Css NA 0.05168 mg/L PBTK NA 50% Rat Human +DTXSID3057698 Css NA 0.2466 mg/L PBTK NA 95% Rat Human +DTXSID3057721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057721 Fup 0.0945 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057721 Vd NA 1.238 L/kg 1compartment NA NA Human Human +DTXSID3057721 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3057721 TK.Half.Life NA 3.488 hours 1compartment NA NA Human Human +DTXSID3057721 Css NA 0.3058 mg/L 3compartmentss NA 50% Human Human +DTXSID3057721 Css NA 2.492 mg/L 3compartmentss NA 95% Human Human +DTXSID3057721 Css NA 0.2001 mg/L PBTK NA 50% Human Human +DTXSID3057721 Css NA 1.539 mg/L PBTK NA 95% Human Human +DTXSID3057721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057721 Fup 0.0945 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057721 Vd NA 0.9561 L/kg 1compartment NA NA Rat Human +DTXSID3057721 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3057721 TK.Half.Life NA 1.443 hours 1compartment NA NA Rat Human +DTXSID3057721 Css NA 0.04041 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057721 Css NA 0.2474 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057721 Css NA 0.02569 mg/L PBTK NA 50% Rat Human +DTXSID3057721 Css NA 0.1498 mg/L PBTK NA 95% Rat Human +DTXSID3057723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID3057723 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID3057723 Vd NA 0.5718 L/kg 1compartment NA NA Human Human +DTXSID3057723 Vd NA 0.7184 L/kg 1compartment NA NA Human Human DTXSID3057723 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057723 TK.Half.Life NA 2.168 hours 1compartment NA NA Human Human -DTXSID3057723 Css NA 0.5236 mg/L 3compartmentss NA 50% Human Human -DTXSID3057723 Css NA 4.022 mg/L 3compartmentss NA 95% Human Human -DTXSID3057723 Css NA 0.3218 mg/L PBTK NA 50% Human Human -DTXSID3057723 Css NA 2.384 mg/L PBTK NA 95% Human Human -DTXSID3057723 Clint NA 21.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID3057723 TK.Half.Life NA 2.673 hours 1compartment NA NA Human Human +DTXSID3057723 Css NA 0.4907 mg/L 3compartmentss NA 50% Human Human +DTXSID3057723 Css NA 3.904 mg/L 3compartmentss NA 95% Human Human +DTXSID3057723 Css NA 0.3047 mg/L PBTK NA 50% Human Human +DTXSID3057723 Css NA 2.311 mg/L PBTK NA 95% Human Human +DTXSID3057723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID3057723 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID3057723 Vd NA 0.4662 L/kg 1compartment NA NA Rat Human +DTXSID3057723 Vd NA 0.5687 L/kg 1compartment NA NA Rat Human DTXSID3057723 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057723 TK.Half.Life NA 1.071 hours 1compartment NA NA Rat Human -DTXSID3057723 Css NA 0.2944 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057723 Css NA 1.837 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057723 Css NA 0.1693 mg/L PBTK NA 50% Rat Human -DTXSID3057723 Css NA 1.021 mg/L PBTK NA 95% Rat Human -DTXSID3057725 Clint NA 0.002453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057725 Fup NA 0.4652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057725 Vd NA 0.4555 L/kg 1compartment NA NA Human Human +DTXSID3057723 TK.Half.Life NA 1.259 hours 1compartment NA NA Rat Human +DTXSID3057723 Css NA 0.06347 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057723 Css NA 0.4047 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057723 Css NA 0.0383 mg/L PBTK NA 50% Rat Human +DTXSID3057723 Css NA 0.2352 mg/L PBTK NA 95% Rat Human +DTXSID3057725 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057725 Fup 0.688 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057725 Vd NA 0.5857 L/kg 1compartment NA NA Human Human DTXSID3057725 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057725 TK.Half.Life NA 6.307 hours 1compartment NA NA Human Human -DTXSID3057725 Css NA 1.579 mg/L 3compartmentss NA 50% Human Human -DTXSID3057725 Css NA 7.722 mg/L 3compartmentss NA 95% Human Human -DTXSID3057725 Css NA 1.157 mg/L PBTK NA 50% Human Human -DTXSID3057725 Css NA 4.849 mg/L PBTK NA 95% Human Human -DTXSID3057725 Clint NA 0.002453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057725 Fup NA 0.4652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057725 Vd NA 0.4633 L/kg 1compartment NA NA Rat Human +DTXSID3057725 TK.Half.Life NA 5.51 hours 1compartment NA NA Human Human +DTXSID3057725 Css NA 0.9628 mg/L 3compartmentss NA 50% Human Human +DTXSID3057725 Css NA 6.214 mg/L 3compartmentss NA 95% Human Human +DTXSID3057725 Css NA 0.7637 mg/L PBTK NA 50% Human Human +DTXSID3057725 Css NA 3.896 mg/L PBTK NA 95% Human Human +DTXSID3057725 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057725 Fup 0.688 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057725 Vd NA 0.5952 L/kg 1compartment NA NA Rat Human DTXSID3057725 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057725 TK.Half.Life NA 2.192 hours 1compartment NA NA Rat Human -DTXSID3057725 Css NA 0.4372 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057725 Css NA 1.834 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057725 Css NA 0.3046 mg/L PBTK NA 50% Rat Human -DTXSID3057725 Css NA 1.072 mg/L PBTK NA 95% Rat Human -DTXSID3057727 Clint NA 6.649 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057727 Fup NA 0.0858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057727 Vd NA 2.365 L/kg 1compartment NA NA Human Human -DTXSID3057727 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID3057727 TK.Half.Life NA 23.28 hours 1compartment NA NA Human Human -DTXSID3057727 Css NA 1.292 mg/L 3compartmentss NA 50% Human Human -DTXSID3057727 Css NA 7.961 mg/L 3compartmentss NA 95% Human Human -DTXSID3057727 Css NA 0.9214 mg/L PBTK NA 50% Human Human -DTXSID3057727 Css NA 5.28 mg/L PBTK NA 95% Human Human -DTXSID3057727 Clint NA 6.649 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057727 Fup NA 0.0858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057727 Vd NA 1.899 L/kg 1compartment NA NA Rat Human -DTXSID3057727 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3057727 TK.Half.Life NA 7.779 hours 1compartment NA NA Rat Human -DTXSID3057727 Css NA 0.6833 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057727 Css NA 3.188 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057727 Css NA 0.4625 mg/L PBTK NA 50% Rat Human -DTXSID3057727 Css NA 1.958 mg/L PBTK NA 95% Rat Human -DTXSID3057729 Clint NA 12.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057729 Fup NA 0.135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057729 Vd NA 1.769 L/kg 1compartment NA NA Human Human +DTXSID3057725 TK.Half.Life NA 1.907 hours 1compartment NA NA Rat Human +DTXSID3057725 Css NA 0.01849 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057725 Css NA 0.1436 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057725 Css NA 0.01402 mg/L PBTK NA 50% Rat Human +DTXSID3057725 Css NA 0.09087 mg/L PBTK NA 95% Rat Human +DTXSID3057729 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057729 Fup 0.0831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057729 Vd NA 1.542 L/kg 1compartment NA NA Human Human DTXSID3057729 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057729 TK.Half.Life NA 6.4 hours 1compartment NA NA Human Human -DTXSID3057729 Css NA 0.4111 mg/L 3compartmentss NA 50% Human Human -DTXSID3057729 Css NA 2.912 mg/L 3compartmentss NA 95% Human Human -DTXSID3057729 Css NA 0.2831 mg/L PBTK NA 50% Human Human -DTXSID3057729 Css NA 1.843 mg/L PBTK NA 95% Human Human -DTXSID3057729 Clint NA 12.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057729 Fup NA 0.135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057729 Vd NA 1.357 L/kg 1compartment NA NA Rat Human +DTXSID3057729 TK.Half.Life NA 5.052 hours 1compartment NA NA Human Human +DTXSID3057729 Css NA 0.378 mg/L 3compartmentss NA 50% Human Human +DTXSID3057729 Css NA 2.849 mg/L 3compartmentss NA 95% Human Human +DTXSID3057729 Css NA 0.2481 mg/L PBTK NA 50% Human Human +DTXSID3057729 Css NA 1.777 mg/L PBTK NA 95% Human Human +DTXSID3057729 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057729 Fup 0.0831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057729 Vd NA 1.173 L/kg 1compartment NA NA Rat Human DTXSID3057729 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057729 TK.Half.Life NA 2.314 hours 1compartment NA NA Rat Human -DTXSID3057729 Css NA 0.2255 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057729 Css NA 1.174 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057729 Css NA 0.1472 mg/L PBTK NA 50% Rat Human -DTXSID3057729 Css NA 0.7255 mg/L PBTK NA 95% Rat Human -DTXSID3057771 Clint NA 15.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057771 Fup NA 0.0093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057771 Vd NA 0.179 L/kg 1compartment NA NA Human Human -DTXSID3057771 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057771 TK.Half.Life NA 4.926 hours 1compartment NA NA Human Human -DTXSID3057771 Css NA 5.065 mg/L 3compartmentss NA 50% Human Human -DTXSID3057771 Css NA 47.01 mg/L 3compartmentss NA 95% Human Human -DTXSID3057771 Css NA 2.958 mg/L PBTK NA 50% Human Human -DTXSID3057771 Css NA 27.35 mg/L PBTK NA 95% Human Human -DTXSID3057771 Clint NA 15.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057771 Fup NA 0.0093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057771 Vd NA 0.1762 L/kg 1compartment NA NA Rat Human +DTXSID3057729 TK.Half.Life NA 1.932 hours 1compartment NA NA Rat Human +DTXSID3057729 Css NA 0.04924 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057729 Css NA 0.2707 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057729 Css NA 0.03173 mg/L PBTK NA 50% Rat Human +DTXSID3057729 Css NA 0.164 mg/L PBTK NA 95% Rat Human +DTXSID3057771 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057771 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057771 Vd NA 1.796 L/kg 1compartment NA NA Human Human +DTXSID3057771 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID3057771 TK.Half.Life NA 14.09 hours 1compartment NA NA Human Human +DTXSID3057771 Css NA 1.044 mg/L 3compartmentss NA 50% Human Human +DTXSID3057771 Css NA 6.245 mg/L 3compartmentss NA 95% Human Human +DTXSID3057771 Css NA 0.7028 mg/L PBTK NA 50% Human Human +DTXSID3057771 Css NA 3.999 mg/L PBTK NA 95% Human Human +DTXSID3057771 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057771 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057771 Vd NA 1.367 L/kg 1compartment NA NA Rat Human DTXSID3057771 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057771 TK.Half.Life NA 3.231 hours 1compartment NA NA Rat Human -DTXSID3057771 Css NA 2.844 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057771 Css NA 22.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057771 Css NA 1.55 mg/L PBTK NA 50% Rat Human -DTXSID3057771 Css NA 12.09 mg/L PBTK NA 95% Rat Human -DTXSID3057773 Clint NA 7.286 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057773 Fup NA 0.1006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057773 Vd NA 1.183 L/kg 1compartment NA NA Human Human +DTXSID3057771 TK.Half.Life NA 4.878 hours 1compartment NA NA Rat Human +DTXSID3057771 Css NA 0.1254 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057771 Css NA 0.5924 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057771 Css NA 0.08287 mg/L PBTK NA 50% Rat Human +DTXSID3057771 Css NA 0.363 mg/L PBTK NA 95% Rat Human +DTXSID3057773 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057773 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057773 Vd NA 1.23 L/kg 1compartment NA NA Human Human DTXSID3057773 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057773 TK.Half.Life NA 7.149 hours 1compartment NA NA Human Human -DTXSID3057773 Css NA 0.8411 mg/L 3compartmentss NA 50% Human Human -DTXSID3057773 Css NA 5.572 mg/L 3compartmentss NA 95% Human Human -DTXSID3057773 Css NA 0.5523 mg/L PBTK NA 50% Human Human -DTXSID3057773 Css NA 3.478 mg/L PBTK NA 95% Human Human -DTXSID3057773 Clint NA 7.286 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057773 Fup NA 0.1006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057773 Vd NA 0.919 L/kg 1compartment NA NA Rat Human +DTXSID3057773 TK.Half.Life NA 7.8 hours 1compartment NA NA Human Human +DTXSID3057773 Css NA 0.8436 mg/L 3compartmentss NA 50% Human Human +DTXSID3057773 Css NA 5.78 mg/L 3compartmentss NA 95% Human Human +DTXSID3057773 Css NA 0.557 mg/L PBTK NA 50% Human Human +DTXSID3057773 Css NA 3.61 mg/L PBTK NA 95% Human Human +DTXSID3057773 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057773 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057773 Vd NA 0.9576 L/kg 1compartment NA NA Rat Human DTXSID3057773 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057773 TK.Half.Life NA 3.028 hours 1compartment NA NA Rat Human -DTXSID3057773 Css NA 0.4439 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057773 Css NA 2.248 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057773 Css NA 0.2734 mg/L PBTK NA 50% Rat Human -DTXSID3057773 Css NA 1.287 mg/L PBTK NA 95% Rat Human -DTXSID3057775 Clint NA 251.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057775 Fup NA 0.4529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057775 Vd NA 0.7311 L/kg 1compartment NA NA Human Human +DTXSID3057773 TK.Half.Life NA 3.253 hours 1compartment NA NA Rat Human +DTXSID3057773 Css NA 0.1018 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057773 Css NA 0.5247 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057773 Css NA 0.06578 mg/L PBTK NA 50% Rat Human +DTXSID3057773 Css NA 0.313 mg/L PBTK NA 95% Rat Human +DTXSID3057775 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057775 Fup 0.385 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057775 Vd NA 0.6462 L/kg 1compartment NA NA Human Human DTXSID3057775 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057775 TK.Half.Life NA 0.5411 hours 1compartment NA NA Human Human -DTXSID3057775 Css NA 0.004138 mg/L 3compartmentss NA 50% Human Human -DTXSID3057775 Css NA 0.0375 mg/L 3compartmentss NA 95% Human Human -DTXSID3057775 Css NA 0.00312 mg/L PBTK NA 50% Human Human -DTXSID3057775 Css NA 0.02537 mg/L PBTK NA 95% Human Human -DTXSID3057775 Clint NA 251.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057775 Fup NA 0.4529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057775 Vd NA 0.6786 L/kg 1compartment NA NA Rat Human +DTXSID3057775 TK.Half.Life NA 1.365 hours 1compartment NA NA Human Human +DTXSID3057775 Css NA 0.1728 mg/L 3compartmentss NA 50% Human Human +DTXSID3057775 Css NA 1.161 mg/L 3compartmentss NA 95% Human Human +DTXSID3057775 Css NA 0.1256 mg/L PBTK NA 50% Human Human +DTXSID3057775 Css NA 0.7598 mg/L PBTK NA 95% Human Human +DTXSID3057775 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057775 Fup 0.385 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057775 Vd NA 0.6032 L/kg 1compartment NA NA Rat Human DTXSID3057775 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057775 TK.Half.Life NA 0.2219 hours 1compartment NA NA Rat Human -DTXSID3057775 Css NA 0.002266 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057775 Css NA 0.01692 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057775 Css NA 0.001634 mg/L PBTK NA 50% Rat Human -DTXSID3057775 Css NA 0.01099 mg/L PBTK NA 95% Rat Human -DTXSID3057777 Clint NA 0.961 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057777 Fup NA 0.3043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057777 Vd NA 2.208 L/kg 1compartment NA NA Human Human -DTXSID3057777 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID3057777 TK.Half.Life NA 33.32 hours 1compartment NA NA Human Human -DTXSID3057777 Css NA 1.636 mg/L 3compartmentss NA 50% Human Human -DTXSID3057777 Css NA 5.928 mg/L 3compartmentss NA 95% Human Human -DTXSID3057777 Css NA 1.259 mg/L PBTK NA 50% Human Human -DTXSID3057777 Css NA 4.082 mg/L PBTK NA 95% Human Human -DTXSID3057777 Clint NA 0.961 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057777 Fup NA 0.3043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057777 Vd NA 1.717 L/kg 1compartment NA NA Rat Human -DTXSID3057777 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID3057777 TK.Half.Life NA 8.196 hours 1compartment NA NA Rat Human -DTXSID3057777 Css NA 0.6679 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057777 Css NA 1.95 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057777 Css NA 0.4924 mg/L PBTK NA 50% Rat Human -DTXSID3057777 Css NA 1.227 mg/L PBTK NA 95% Rat Human -DTXSID3057779 Clint NA 259.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057779 Fup NA 0.2371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057779 Vd NA 1.835 L/kg 1compartment NA NA Human Human +DTXSID3057775 TK.Half.Life NA 0.7065 hours 1compartment NA NA Rat Human +DTXSID3057775 Css NA 0.02019 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057775 Css NA 0.09642 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057775 Css NA 0.01464 mg/L PBTK NA 50% Rat Human +DTXSID3057775 Css NA 0.0624 mg/L PBTK NA 95% Rat Human +DTXSID3057777 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057777 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057777 Vd NA 2.41 L/kg 1compartment NA NA Human Human +DTXSID3057777 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3057777 TK.Half.Life NA 8.437 hours 1compartment NA NA Human Human +DTXSID3057777 Css NA 0.3655 mg/L 3compartmentss NA 50% Human Human +DTXSID3057777 Css NA 2.568 mg/L 3compartmentss NA 95% Human Human +DTXSID3057777 Css NA 0.2538 mg/L PBTK NA 50% Human Human +DTXSID3057777 Css NA 1.69 mg/L PBTK NA 95% Human Human +DTXSID3057777 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057777 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057777 Vd NA 1.823 L/kg 1compartment NA NA Rat Human +DTXSID3057777 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3057777 TK.Half.Life NA 2.364 hours 1compartment NA NA Rat Human +DTXSID3057777 Css NA 0.04666 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057777 Css NA 0.2482 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057777 Css NA 0.03196 mg/L PBTK NA 50% Rat Human +DTXSID3057777 Css NA 0.163 mg/L PBTK NA 95% Rat Human +DTXSID3057779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057779 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057779 Vd NA 1.716 L/kg 1compartment NA NA Human Human DTXSID3057779 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057779 TK.Half.Life NA 1.53 hours 1compartment NA NA Human Human -DTXSID3057779 Css NA 0.01031 mg/L 3compartmentss NA 50% Human Human -DTXSID3057779 Css NA 0.07369 mg/L 3compartmentss NA 95% Human Human -DTXSID3057779 Css NA 0.007612 mg/L PBTK NA 50% Human Human -DTXSID3057779 Css NA 0.05154 mg/L PBTK NA 95% Human Human -DTXSID3057779 Clint NA 259.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057779 Fup NA 0.2371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057779 Vd NA 1.435 L/kg 1compartment NA NA Rat Human +DTXSID3057779 TK.Half.Life NA 2.475 hours 1compartment NA NA Human Human +DTXSID3057779 Css NA 0.08438 mg/L 3compartmentss NA 50% Human Human +DTXSID3057779 Css NA 0.5966 mg/L 3compartmentss NA 95% Human Human +DTXSID3057779 Css NA 0.0638 mg/L PBTK NA 50% Human Human +DTXSID3057779 Css NA 0.419 mg/L PBTK NA 95% Human Human +DTXSID3057779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057779 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057779 Vd NA 1.367 L/kg 1compartment NA NA Rat Human DTXSID3057779 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057779 TK.Half.Life NA 0.5251 hours 1compartment NA NA Rat Human -DTXSID3057779 Css NA 0.005748 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057779 Css NA 0.03373 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057779 Css NA 0.004078 mg/L PBTK NA 50% Rat Human -DTXSID3057779 Css NA 0.02286 mg/L PBTK NA 95% Rat Human -DTXSID3057800 Clint NA 10.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057800 Fup NA 0.2291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057800 Vd NA 1.517 L/kg 1compartment NA NA Human Human +DTXSID3057779 TK.Half.Life NA 0.9316 hours 1compartment NA NA Rat Human +DTXSID3057779 Css NA 0.01046 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057779 Css NA 0.05599 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057779 Css NA 0.00796 mg/L PBTK NA 50% Rat Human +DTXSID3057779 Css NA 0.03974 mg/L PBTK NA 95% Rat Human +DTXSID3057800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057800 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057800 Vd NA 2.18 L/kg 1compartment NA NA Human Human DTXSID3057800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057800 TK.Half.Life NA 3.571 hours 1compartment NA NA Human Human -DTXSID3057800 Css NA 0.1988 mg/L 3compartmentss NA 50% Human Human -DTXSID3057800 Css NA 1.268 mg/L 3compartmentss NA 95% Human Human -DTXSID3057800 Css NA 0.1497 mg/L PBTK NA 50% Human Human -DTXSID3057800 Css NA 0.8594 mg/L PBTK NA 95% Human Human -DTXSID3057800 Clint NA 10.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057800 Fup NA 0.2291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057800 Vd NA 1.303 L/kg 1compartment NA NA Rat Human +DTXSID3057800 TK.Half.Life NA 4.513 hours 1compartment NA NA Human Human +DTXSID3057800 Css NA 0.1537 mg/L 3compartmentss NA 50% Human Human +DTXSID3057800 Css NA 1.021 mg/L 3compartmentss NA 95% Human Human +DTXSID3057800 Css NA 0.1358 mg/L PBTK NA 50% Human Human +DTXSID3057800 Css NA 0.7518 mg/L PBTK NA 95% Human Human +DTXSID3057800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057800 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057800 Vd NA 1.896 L/kg 1compartment NA NA Rat Human DTXSID3057800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057800 TK.Half.Life NA 1.631 hours 1compartment NA NA Rat Human -DTXSID3057800 Css NA 0.1044 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057800 Css NA 0.4811 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057800 Css NA 0.07597 mg/L PBTK NA 50% Rat Human -DTXSID3057800 Css NA 0.3151 mg/L PBTK NA 95% Rat Human -DTXSID3057802 Clint NA 9.471 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057802 Fup NA 0.1943 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057802 Vd NA 0.4895 L/kg 1compartment NA NA Human Human +DTXSID3057800 TK.Half.Life NA 1.865 hours 1compartment NA NA Rat Human +DTXSID3057800 Css NA 0.01756 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057800 Css NA 0.09345 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057800 Css NA 0.01579 mg/L PBTK NA 50% Rat Human +DTXSID3057800 Css NA 0.06643 mg/L PBTK NA 95% Rat Human +DTXSID3057802 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057802 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057802 Vd NA 0.5891 L/kg 1compartment NA NA Human Human DTXSID3057802 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057802 TK.Half.Life NA 1.336 hours 1compartment NA NA Human Human -DTXSID3057802 Css NA 0.2577 mg/L 3compartmentss NA 50% Human Human -DTXSID3057802 Css NA 1.565 mg/L 3compartmentss NA 95% Human Human -DTXSID3057802 Css NA 0.1732 mg/L PBTK NA 50% Human Human -DTXSID3057802 Css NA 0.987 mg/L PBTK NA 95% Human Human -DTXSID3057802 Clint NA 9.471 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057802 Fup NA 0.1943 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057802 Vd NA 0.4628 L/kg 1compartment NA NA Rat Human +DTXSID3057802 TK.Half.Life NA 1.781 hours 1compartment NA NA Human Human +DTXSID3057802 Css NA 0.2813 mg/L 3compartmentss NA 50% Human Human +DTXSID3057802 Css NA 1.729 mg/L 3compartmentss NA 95% Human Human +DTXSID3057802 Css NA 0.1955 mg/L PBTK NA 50% Human Human +DTXSID3057802 Css NA 1.112 mg/L PBTK NA 95% Human Human +DTXSID3057802 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057802 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057802 Vd NA 0.5487 L/kg 1compartment NA NA Rat Human DTXSID3057802 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057802 TK.Half.Life NA 0.7365 hours 1compartment NA NA Rat Human -DTXSID3057802 Css NA 0.1358 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057802 Css NA 0.6258 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057802 Css NA 0.08636 mg/L PBTK NA 50% Rat Human -DTXSID3057802 Css NA 0.37 mg/L PBTK NA 95% Rat Human -DTXSID3057804 Clint NA 0.2835 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057804 Fup NA 0.636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057804 Vd NA 1.034 L/kg 1compartment NA NA Human Human +DTXSID3057802 TK.Half.Life NA 0.9555 hours 1compartment NA NA Rat Human +DTXSID3057802 Css NA 0.03399 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057802 Css NA 0.1477 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057802 Css NA 0.02324 mg/L PBTK NA 50% Rat Human +DTXSID3057802 Css NA 0.09228 mg/L PBTK NA 95% Rat Human +DTXSID3057804 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057804 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057804 Vd NA 1.107 L/kg 1compartment NA NA Human Human DTXSID3057804 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057804 TK.Half.Life NA 7.481 hours 1compartment NA NA Human Human -DTXSID3057804 Css NA 0.7506 mg/L 3compartmentss NA 50% Human Human -DTXSID3057804 Css NA 5.14 mg/L 3compartmentss NA 95% Human Human -DTXSID3057804 Css NA 0.6406 mg/L PBTK NA 50% Human Human -DTXSID3057804 Css NA 3.347 mg/L PBTK NA 95% Human Human -DTXSID3057804 Clint NA 0.2835 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057804 Fup NA 0.636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057804 Vd NA 0.9727 L/kg 1compartment NA NA Rat Human +DTXSID3057804 TK.Half.Life NA 1.843 hours 1compartment NA NA Human Human +DTXSID3057804 Css NA 0.1216 mg/L 3compartmentss NA 50% Human Human +DTXSID3057804 Css NA 0.9611 mg/L 3compartmentss NA 95% Human Human +DTXSID3057804 Css NA 0.09948 mg/L PBTK NA 50% Human Human +DTXSID3057804 Css NA 0.6723 mg/L PBTK NA 95% Human Human +DTXSID3057804 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057804 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057804 Vd NA 1.001 L/kg 1compartment NA NA Rat Human DTXSID3057804 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057804 TK.Half.Life NA 2.775 hours 1compartment NA NA Rat Human -DTXSID3057804 Css NA 0.2399 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057804 Css NA 1.611 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057804 Css NA 0.1982 mg/L PBTK NA 50% Rat Human -DTXSID3057804 Css NA 0.9669 mg/L PBTK NA 95% Rat Human -DTXSID3057806 Clint NA 29.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057806 Fup NA 0.0917 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057806 Vd NA 1.708 L/kg 1compartment NA NA Human Human +DTXSID3057804 TK.Half.Life NA 0.8867 hours 1compartment NA NA Rat Human +DTXSID3057804 Css NA 0.01388 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057804 Css NA 0.091 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057804 Css NA 0.01156 mg/L PBTK NA 50% Rat Human +DTXSID3057804 Css NA 0.05955 mg/L PBTK NA 95% Rat Human +DTXSID3057806 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057806 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057806 Vd NA 2.372 L/kg 1compartment NA NA Human Human DTXSID3057806 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057806 TK.Half.Life NA 3.954 hours 1compartment NA NA Human Human -DTXSID3057806 Css NA 0.2338 mg/L 3compartmentss NA 50% Human Human -DTXSID3057806 Css NA 1.884 mg/L 3compartmentss NA 95% Human Human -DTXSID3057806 Css NA 0.1627 mg/L PBTK NA 50% Human Human -DTXSID3057806 Css NA 1.236 mg/L PBTK NA 95% Human Human -DTXSID3057806 Clint NA 29.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057806 Fup NA 0.0917 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057806 Vd NA 1.437 L/kg 1compartment NA NA Rat Human +DTXSID3057806 TK.Half.Life NA 11.04 hours 1compartment NA NA Human Human +DTXSID3057806 Css NA 0.4338 mg/L 3compartmentss NA 50% Human Human +DTXSID3057806 Css NA 2.541 mg/L 3compartmentss NA 95% Human Human +DTXSID3057806 Css NA 0.3444 mg/L PBTK NA 50% Human Human +DTXSID3057806 Css NA 1.844 mg/L PBTK NA 95% Human Human +DTXSID3057806 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057806 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057806 Vd NA 2.022 L/kg 1compartment NA NA Rat Human DTXSID3057806 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057806 TK.Half.Life NA 1.746 hours 1compartment NA NA Rat Human -DTXSID3057806 Css NA 0.1302 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057806 Css NA 0.8232 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057806 Css NA 0.08573 mg/L PBTK NA 50% Rat Human -DTXSID3057806 Css NA 0.5072 mg/L PBTK NA 95% Rat Human -DTXSID3057808 Clint NA 0.02971 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057808 Fup NA 0.8566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057808 Vd NA 1.11 L/kg 1compartment NA NA Human Human +DTXSID3057806 TK.Half.Life NA 4.348 hours 1compartment NA NA Rat Human +DTXSID3057806 Css NA 0.05136 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057806 Css NA 0.2146 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057806 Css NA 0.04125 mg/L PBTK NA 50% Rat Human +DTXSID3057806 Css NA 0.1502 mg/L PBTK NA 95% Rat Human +DTXSID3057808 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057808 Fup 0.658 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057808 Vd NA 0.728 L/kg 1compartment NA NA Human Human DTXSID3057808 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057808 TK.Half.Life NA 8.017 hours 1compartment NA NA Human Human -DTXSID3057808 Css NA 0.847 mg/L 3compartmentss NA 50% Human Human -DTXSID3057808 Css NA 5.46 mg/L 3compartmentss NA 95% Human Human -DTXSID3057808 Css NA 0.7419 mg/L PBTK NA 50% Human Human -DTXSID3057808 Css NA 3.571 mg/L PBTK NA 95% Human Human -DTXSID3057808 Clint NA 0.02971 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057808 Fup NA 0.8566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057808 Vd NA 1.128 L/kg 1compartment NA NA Rat Human +DTXSID3057808 TK.Half.Life NA 7.158 hours 1compartment NA NA Human Human +DTXSID3057808 Css NA 0.9758 mg/L 3compartmentss NA 50% Human Human +DTXSID3057808 Css NA 6.434 mg/L 3compartmentss NA 95% Human Human +DTXSID3057808 Css NA 0.78 mg/L PBTK NA 50% Human Human +DTXSID3057808 Css NA 4.097 mg/L PBTK NA 95% Human Human +DTXSID3057808 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057808 Fup 0.658 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057808 Vd NA 0.7583 L/kg 1compartment NA NA Rat Human DTXSID3057808 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057808 TK.Half.Life NA 2.838 hours 1compartment NA NA Rat Human -DTXSID3057808 Css NA 0.2228 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057808 Css NA 1.373 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057808 Css NA 0.1911 mg/L PBTK NA 50% Rat Human -DTXSID3057808 Css NA 0.8402 mg/L PBTK NA 95% Rat Human -DTXSID3057850 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057850 Fup NA 0.4795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057850 Vd NA 0.8868 L/kg 1compartment NA NA Human Human -DTXSID3057850 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID3057850 TK.Half.Life NA 12.62 hours 1compartment NA NA Human Human -DTXSID3057850 Css NA 1.535 mg/L 3compartmentss NA 50% Human Human -DTXSID3057850 Css NA 7.476 mg/L 3compartmentss NA 95% Human Human -DTXSID3057850 Css NA 1.201 mg/L PBTK NA 50% Human Human -DTXSID3057850 Css NA 4.81 mg/L PBTK NA 95% Human Human -DTXSID3057850 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057850 Fup NA 0.4795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057850 Vd NA 0.7916 L/kg 1compartment NA NA Rat Human +DTXSID3057808 TK.Half.Life NA 2.541 hours 1compartment NA NA Rat Human +DTXSID3057808 Css NA 0.01859 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057808 Css NA 0.1585 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057808 Css NA 0.01435 mg/L PBTK NA 50% Rat Human +DTXSID3057808 Css NA 0.1003 mg/L PBTK NA 95% Rat Human +DTXSID3057850 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057850 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057850 Vd NA 0.4265 L/kg 1compartment NA NA Human Human +DTXSID3057850 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3057850 TK.Half.Life NA 0.7922 hours 1compartment NA NA Human Human +DTXSID3057850 Css NA 0.07427 mg/L 3compartmentss NA 50% Human Human +DTXSID3057850 Css NA 0.5695 mg/L 3compartmentss NA 95% Human Human +DTXSID3057850 Css NA 0.05321 mg/L PBTK NA 50% Human Human +DTXSID3057850 Css NA 0.3687 mg/L PBTK NA 95% Human Human +DTXSID3057850 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057850 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057850 Vd NA 0.4325 L/kg 1compartment NA NA Rat Human DTXSID3057850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057850 TK.Half.Life NA 3.687 hours 1compartment NA NA Rat Human -DTXSID3057850 Css NA 0.4131 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057850 Css NA 1.722 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057850 Css NA 0.3092 mg/L PBTK NA 50% Rat Human -DTXSID3057850 Css NA 1.037 mg/L PBTK NA 95% Rat Human -DTXSID3057852 Clint NA 256.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057852 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057852 Vd NA 47.8 L/kg 1compartment NA NA Human Human -DTXSID3057852 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID3057852 TK.Half.Life NA 123.9 hours 1compartment NA NA Human Human -DTXSID3057852 Css NA 0.03913 mg/L 3compartmentss NA 50% Human Human -DTXSID3057852 Css NA 0.2364 mg/L 3compartmentss NA 95% Human Human -DTXSID3057852 Css NA 0.2072 mg/L PBTK NA 50% Human Human -DTXSID3057852 Css NA 1.126 mg/L PBTK NA 95% Human Human -DTXSID3057852 Clint NA 256.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057852 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057852 Vd NA 40.21 L/kg 1compartment NA NA Rat Human -DTXSID3057852 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID3057852 TK.Half.Life NA 19 hours 1compartment NA NA Rat Human -DTXSID3057852 Css NA 0.02024 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057852 Css NA 0.08757 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057852 Css NA 0.1119 mg/L PBTK NA 50% Rat Human -DTXSID3057852 Css NA 0.4679 mg/L PBTK NA 95% Rat Human -DTXSID3057854 Clint NA 15.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057854 Fup NA 0.0324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057854 Vd NA 3.082 L/kg 1compartment NA NA Human Human -DTXSID3057854 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID3057854 TK.Half.Life NA 92.2 hours 1compartment NA NA Human Human -DTXSID3057854 Css NA 3.736 mg/L 3compartmentss NA 50% Human Human -DTXSID3057854 Css NA 24.11 mg/L 3compartmentss NA 95% Human Human -DTXSID3057854 Css NA 2.57 mg/L PBTK NA 50% Human Human -DTXSID3057854 Css NA 16.14 mg/L PBTK NA 95% Human Human -DTXSID3057854 Clint NA 15.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057854 Fup NA 0.0324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057854 Vd NA 2.309 L/kg 1compartment NA NA Rat Human -DTXSID3057854 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID3057854 TK.Half.Life NA 13.07 hours 1compartment NA NA Rat Human -DTXSID3057854 Css NA 2.08 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057854 Css NA 10.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057854 Css NA 1.37 mg/L PBTK NA 50% Rat Human -DTXSID3057854 Css NA 6.993 mg/L PBTK NA 95% Rat Human -DTXSID3057856 Clint NA 3300 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057856 Fup NA 0.8261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057856 Vd NA 0.8151 L/kg 1compartment NA NA Human Human +DTXSID3057850 TK.Half.Life NA 0.4409 hours 1compartment NA NA Rat Human +DTXSID3057850 Css NA 0.0006841 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057850 Css NA 0.004805 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057850 Css NA 0.0004718 mg/L PBTK NA 50% Rat Human +DTXSID3057850 Css NA 0.002925 mg/L PBTK NA 95% Rat Human +DTXSID3057852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057852 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057852 Vd NA 10.73 L/kg 1compartment NA NA Human Human +DTXSID3057852 Days.Css NA 67 Days PBTK NA NA Human Human +DTXSID3057852 TK.Half.Life NA 319.7 hours 1compartment NA NA Human Human +DTXSID3057852 Css NA 1.872 mg/L 3compartmentss NA 50% Human Human +DTXSID3057852 Css NA 11.59 mg/L 3compartmentss NA 95% Human Human +DTXSID3057852 Css NA 2.343 mg/L PBTK NA 50% Human Human +DTXSID3057852 Css NA 14.04 mg/L PBTK NA 95% Human Human +DTXSID3057852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057852 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057852 Vd NA 8.476 L/kg 1compartment NA NA Rat Human +DTXSID3057852 Days.Css NA 40 Days PBTK NA NA Rat Human +DTXSID3057852 TK.Half.Life NA 44.21 hours 1compartment NA NA Rat Human +DTXSID3057852 Css NA 0.2368 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057852 Css NA 1.152 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057852 Css NA 0.3078 mg/L PBTK NA 50% Rat Human +DTXSID3057852 Css NA 1.576 mg/L PBTK NA 95% Rat Human +DTXSID3057854 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057854 Fup 0.0084 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057854 Vd NA 2.677 L/kg 1compartment NA NA Human Human +DTXSID3057854 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID3057854 TK.Half.Life NA 54.62 hours 1compartment NA NA Human Human +DTXSID3057854 Css NA 2.841 mg/L 3compartmentss NA 50% Human Human +DTXSID3057854 Css NA 20.28 mg/L 3compartmentss NA 95% Human Human +DTXSID3057854 Css NA 1.888 mg/L PBTK NA 50% Human Human +DTXSID3057854 Css NA 13.08 mg/L PBTK NA 95% Human Human +DTXSID3057854 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057854 Fup 0.0084 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057854 Vd NA 1.997 L/kg 1compartment NA NA Rat Human +DTXSID3057854 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID3057854 TK.Half.Life NA 11.76 hours 1compartment NA NA Rat Human +DTXSID3057854 Css NA 0.3669 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057854 Css NA 2.263 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057854 Css NA 0.2404 mg/L PBTK NA 50% Rat Human +DTXSID3057854 Css NA 1.425 mg/L PBTK NA 95% Rat Human +DTXSID3057856 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057856 Fup 0.651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057856 Vd NA 0.6732 L/kg 1compartment NA NA Human Human DTXSID3057856 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057856 TK.Half.Life NA 0.4751 hours 1compartment NA NA Human Human -DTXSID3057856 Css NA 0.0001948 mg/L 3compartmentss NA 50% Human Human -DTXSID3057856 Css NA 0.002001 mg/L 3compartmentss NA 95% Human Human -DTXSID3057856 Css NA 0.0001596 mg/L PBTK NA 50% Human Human -DTXSID3057856 Css NA 0.001384 mg/L PBTK NA 95% Human Human -DTXSID3057856 Clint NA 3300 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057856 Fup NA 0.8261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057856 Vd NA 0.8299 L/kg 1compartment NA NA Rat Human +DTXSID3057856 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human +DTXSID3057856 Css NA 1.122 mg/L 3compartmentss NA 50% Human Human +DTXSID3057856 Css NA 7.318 mg/L 3compartmentss NA 95% Human Human +DTXSID3057856 Css NA 0.9032 mg/L PBTK NA 50% Human Human +DTXSID3057856 Css NA 4.611 mg/L PBTK NA 95% Human Human +DTXSID3057856 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057856 Fup 0.651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057856 Vd NA 0.6908 L/kg 1compartment NA NA Rat Human DTXSID3057856 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057856 TK.Half.Life NA 0.2081 hours 1compartment NA NA Rat Human -DTXSID3057856 Css NA 9.881e-05 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057856 Css NA 0.001003 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057856 Css NA 8.088e-05 mg/L PBTK NA 50% Rat Human -DTXSID3057856 Css NA 0.0007075 mg/L PBTK NA 95% Rat Human -DTXSID3057858 Clint NA 17.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057858 Fup NA 0.1666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID3057858 Vd NA 0.7693 L/kg 1compartment NA NA Human Human +DTXSID3057856 TK.Half.Life NA 2.34 hours 1compartment NA NA Rat Human +DTXSID3057856 Css NA 0.06802 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057856 Css NA 0.4151 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057856 Css NA 0.05422 mg/L PBTK NA 50% Rat Human +DTXSID3057856 Css NA 0.2534 mg/L PBTK NA 95% Rat Human +DTXSID3057858 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057858 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3057858 Vd NA 1.253 L/kg 1compartment NA NA Human Human DTXSID3057858 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID3057858 TK.Half.Life NA 1.612 hours 1compartment NA NA Human Human -DTXSID3057858 Css NA 0.1762 mg/L 3compartmentss NA 50% Human Human -DTXSID3057858 Css NA 1.148 mg/L 3compartmentss NA 95% Human Human -DTXSID3057858 Css NA 0.1184 mg/L PBTK NA 50% Human Human -DTXSID3057858 Css NA 0.7374 mg/L PBTK NA 95% Human Human -DTXSID3057858 Clint NA 17.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057858 Fup NA 0.1666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID3057858 Vd NA 0.6547 L/kg 1compartment NA NA Rat Human +DTXSID3057858 TK.Half.Life NA 2.039 hours 1compartment NA NA Human Human +DTXSID3057858 Css NA 0.1048 mg/L 3compartmentss NA 50% Human Human +DTXSID3057858 Css NA 0.7374 mg/L 3compartmentss NA 95% Human Human +DTXSID3057858 Css NA 0.07534 mg/L PBTK NA 50% Human Human +DTXSID3057858 Css NA 0.4971 mg/L PBTK NA 95% Human Human +DTXSID3057858 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057858 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3057858 Vd NA 1.017 L/kg 1compartment NA NA Rat Human DTXSID3057858 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID3057858 TK.Half.Life NA 0.7706 hours 1compartment NA NA Rat Human -DTXSID3057858 Css NA 0.09704 mg/L 3compartmentss NA 50% Rat Human -DTXSID3057858 Css NA 0.5024 mg/L 3compartmentss NA 95% Rat Human -DTXSID3057858 Css NA 0.06208 mg/L PBTK NA 50% Rat Human -DTXSID3057858 Css NA 0.2977 mg/L PBTK NA 95% Rat Human +DTXSID3057858 TK.Half.Life NA 0.8535 hours 1compartment NA NA Rat Human +DTXSID3057858 Css NA 0.01325 mg/L 3compartmentss NA 50% Rat Human +DTXSID3057858 Css NA 0.07051 mg/L 3compartmentss NA 95% Rat Human +DTXSID3057858 Css NA 0.009407 mg/L PBTK NA 50% Rat Human +DTXSID3057858 Css NA 0.04747 mg/L PBTK NA 95% Rat Human +DTXSID3058749 Clint 12 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID3058749 Fup 0.016 NA NA Williamson 2020 NA Human Human +DTXSID3058749 Vd NA 2.698 L/kg 1compartment NA NA Human Human +DTXSID3058749 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID3058749 TK.Half.Life NA 74.65 hours 1compartment NA NA Human Human +DTXSID3058749 Css NA 3.322 mg/L 3compartmentss NA 50% Human Human +DTXSID3058749 Css NA 24.1 mg/L 3compartmentss NA 95% Human Human +DTXSID3058749 Css NA 2.215 mg/L PBTK NA 50% Human Human +DTXSID3058749 Css NA 15.4 mg/L PBTK NA 95% Human Human +DTXSID3058749 Clint 12 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID3058749 Fup 0.016 NA NA Williamson 2020 NA Rat Human +DTXSID3058749 Vd NA 2.015 L/kg 1compartment NA NA Rat Human +DTXSID3058749 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID3058749 TK.Half.Life NA 15.6 hours 1compartment NA NA Rat Human +DTXSID3058749 Css NA 0.1267 mg/L 3compartmentss NA 50% Rat Human +DTXSID3058749 Css NA 0.9481 mg/L 3compartmentss NA 95% Rat Human +DTXSID3058749 Css NA 0.08147 mg/L PBTK NA 50% Rat Human +DTXSID3058749 Css NA 0.5942 mg/L PBTK NA 95% Rat Human +DTXSID3059189 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3059189 Fup 0.45 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3059189 Vd NA 0.5806 L/kg 1compartment NA NA Human Human +DTXSID3059189 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3059189 TK.Half.Life NA 8.426 hours 1compartment NA NA Human Human +DTXSID3059189 Css NA 1.475 mg/L 3compartmentss NA 50% Human Human +DTXSID3059189 Css NA 7.052 mg/L 3compartmentss NA 95% Human Human +DTXSID3059189 Css NA 1.087 mg/L PBTK NA 50% Human Human +DTXSID3059189 Css NA 4.466 mg/L PBTK NA 95% Human Human +DTXSID3059189 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3059189 Fup 0.45 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3059189 Vd NA 0.562 L/kg 1compartment NA NA Rat Human +DTXSID3059189 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3059189 TK.Half.Life NA 2.759 hours 1compartment NA NA Rat Human +DTXSID3059189 Css NA 0.05086 mg/L 3compartmentss NA 50% Rat Human +DTXSID3059189 Css NA 0.2526 mg/L 3compartmentss NA 95% Rat Human +DTXSID3059189 Css NA 0.03835 mg/L PBTK NA 50% Rat Human +DTXSID3059189 Css NA 0.1572 mg/L PBTK NA 95% Rat Human +DTXSID3061635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3061635 Fup 0.027 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3061635 Vd NA 2.642 L/kg 1compartment NA NA Human Human +DTXSID3061635 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID3061635 TK.Half.Life NA 30.58 hours 1compartment NA NA Human Human +DTXSID3061635 Css NA 1.534 mg/L 3compartmentss NA 50% Human Human +DTXSID3061635 Css NA 11.72 mg/L 3compartmentss NA 95% Human Human +DTXSID3061635 Css NA 1.031 mg/L PBTK NA 50% Human Human +DTXSID3061635 Css NA 7.565 mg/L PBTK NA 95% Human Human +DTXSID3061635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3061635 Fup 0.027 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3061635 Vd NA 1.975 L/kg 1compartment NA NA Rat Human +DTXSID3061635 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID3061635 TK.Half.Life 0.5 6.883 hours 1compartment Zhu et al. (2016) NA Rat Human +DTXSID3061635 Css NA 0.1987 mg/L 3compartmentss NA 50% Rat Human +DTXSID3061635 Css NA 1.175 mg/L 3compartmentss NA 95% Rat Human +DTXSID3061635 Css NA 0.1309 mg/L PBTK NA 50% Rat Human +DTXSID3061635 Css NA 0.764 mg/L PBTK NA 95% Rat Human +DTXSID3063469 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3063469 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3063469 Vd NA 1.001 L/kg 1compartment NA NA Human Human +DTXSID3063469 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3063469 TK.Half.Life NA 9.224 hours 1compartment NA NA Human Human +DTXSID3063469 Css NA 0.867 mg/L 3compartmentss NA 50% Human Human +DTXSID3063469 Css NA 5.997 mg/L 3compartmentss NA 95% Human Human +DTXSID3063469 Css NA 0.7514 mg/L PBTK NA 50% Human Human +DTXSID3063469 Css NA 3.917 mg/L PBTK NA 95% Human Human +DTXSID3063469 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3063469 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3063469 Vd NA 0.9603 L/kg 1compartment NA NA Rat Human +DTXSID3063469 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3063469 TK.Half.Life NA 2.95 hours 1compartment NA NA Rat Human +DTXSID3063469 Css NA 0.01662 mg/L 3compartmentss NA 50% Rat Human +DTXSID3063469 Css NA 0.132 mg/L 3compartmentss NA 95% Rat Human +DTXSID3063469 Css NA 0.0137 mg/L PBTK NA 50% Rat Human +DTXSID3063469 Css NA 0.08763 mg/L PBTK NA 95% Rat Human +DTXSID3065089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3065089 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3065089 Vd NA 1.014 L/kg 1compartment NA NA Human Human +DTXSID3065089 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID3065089 TK.Half.Life NA 1.585 hours 1compartment NA NA Human Human +DTXSID3065089 Css NA 0.0979 mg/L 3compartmentss NA 50% Human Human +DTXSID3065089 Css NA 0.6668 mg/L 3compartmentss NA 95% Human Human +DTXSID3065089 Css NA 0.06972 mg/L PBTK NA 50% Human Human +DTXSID3065089 Css NA 0.4457 mg/L PBTK NA 95% Human Human +DTXSID3065089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3065089 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3065089 Vd NA 0.8437 L/kg 1compartment NA NA Rat Human +DTXSID3065089 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID3065089 TK.Half.Life NA 0.6966 hours 1compartment NA NA Rat Human +DTXSID3065089 Css NA 0.0123 mg/L 3compartmentss NA 50% Rat Human +DTXSID3065089 Css NA 0.06854 mg/L 3compartmentss NA 95% Rat Human +DTXSID3065089 Css NA 0.008672 mg/L PBTK NA 50% Rat Human +DTXSID3065089 Css NA 0.04533 mg/L PBTK NA 95% Rat Human +DTXSID30669861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30669861 Fup 0.0155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30669861 Vd NA 2.802 L/kg 1compartment NA NA Human Human +DTXSID30669861 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID30669861 TK.Half.Life NA 26.1 hours 1compartment NA NA Human Human +DTXSID30669861 Css NA 1.176 mg/L 3compartmentss NA 50% Human Human +DTXSID30669861 Css NA 8.8 mg/L 3compartmentss NA 95% Human Human +DTXSID30669861 Css NA 0.7998 mg/L PBTK NA 50% Human Human +DTXSID30669861 Css NA 5.731 mg/L PBTK NA 95% Human Human +DTXSID30669861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30669861 Fup 0.0155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30669861 Vd NA 2.128 L/kg 1compartment NA NA Rat Human +DTXSID30669861 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID30669861 TK.Half.Life NA 5.771 hours 1compartment NA NA Rat Human +DTXSID30669861 Css NA 0.1551 mg/L 3compartmentss NA 50% Rat Human +DTXSID30669861 Css NA 0.9272 mg/L 3compartmentss NA 95% Rat Human +DTXSID30669861 Css NA 0.1042 mg/L PBTK NA 50% Rat Human +DTXSID30669861 Css NA 0.5965 mg/L PBTK NA 95% Rat Human +DTXSID30720926 Clint 7.084 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30720926 Fup 0.0551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30720926 Vd NA 2.067 L/kg 1compartment NA NA Human Human +DTXSID30720926 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID30720926 TK.Half.Life NA 18.89 hours 1compartment NA NA Human Human +DTXSID30720926 Css NA 1.084 mg/L 3compartmentss NA 50% Human Human +DTXSID30720926 Css NA 7.617 mg/L 3compartmentss NA 95% Human Human +DTXSID30720926 Css NA 0.7665 mg/L PBTK NA 50% Human Human +DTXSID30720926 Css NA 5.089 mg/L PBTK NA 95% Human Human +DTXSID30720926 Clint 7.084 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30720926 Fup 0.0551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30720926 Vd NA 1.753 L/kg 1compartment NA NA Rat Human +DTXSID30720926 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID30720926 TK.Half.Life NA 8.199 hours 1compartment NA NA Rat Human +DTXSID30720926 Css NA 0.05098 mg/L 3compartmentss NA 50% Rat Human +DTXSID30720926 Css NA 0.4206 mg/L 3compartmentss NA 95% Rat Human +DTXSID30720926 Css NA 0.03542 mg/L PBTK NA 50% Rat Human +DTXSID30720926 Css NA 0.2646 mg/L PBTK NA 95% Rat Human +DTXSID3075044 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3075044 Fup 0.0277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3075044 Vd NA 2.953 L/kg 1compartment NA NA Human Human +DTXSID3075044 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID3075044 TK.Half.Life NA 48.68 hours 1compartment NA NA Human Human +DTXSID3075044 Css NA 2.072 mg/L 3compartmentss NA 50% Human Human +DTXSID3075044 Css NA 14.34 mg/L 3compartmentss NA 95% Human Human +DTXSID3075044 Css NA 1.411 mg/L PBTK NA 50% Human Human +DTXSID3075044 Css NA 9.519 mg/L PBTK NA 95% Human Human +DTXSID3075044 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3075044 Fup 0.0277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3075044 Vd NA 2.212 L/kg 1compartment NA NA Rat Human +DTXSID3075044 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID3075044 TK.Half.Life NA 8.239 hours 1compartment NA NA Rat Human +DTXSID3075044 Css NA 0.2662 mg/L 3compartmentss NA 50% Rat Human +DTXSID3075044 Css NA 1.501 mg/L 3compartmentss NA 95% Rat Human +DTXSID3075044 Css NA 0.1796 mg/L PBTK NA 50% Rat Human +DTXSID3075044 Css NA 0.9835 mg/L PBTK NA 95% Rat Human +DTXSID3075204 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3075204 Fup 0.0206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID3075204 Vd NA 3.046 L/kg 1compartment NA NA Human Human +DTXSID3075204 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID3075204 TK.Half.Life NA 67.76 hours 1compartment NA NA Human Human +DTXSID3075204 Css NA 2.721 mg/L 3compartmentss NA 50% Human Human +DTXSID3075204 Css NA 17.86 mg/L 3compartmentss NA 95% Human Human +DTXSID3075204 Css NA 1.876 mg/L PBTK NA 50% Human Human +DTXSID3075204 Css NA 11.97 mg/L PBTK NA 95% Human Human +DTXSID3075204 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3075204 Fup 0.0206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID3075204 Vd NA 2.281 L/kg 1compartment NA NA Rat Human +DTXSID3075204 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID3075204 TK.Half.Life NA 10.16 hours 1compartment NA NA Rat Human +DTXSID3075204 Css NA 0.3522 mg/L 3compartmentss NA 50% Rat Human +DTXSID3075204 Css NA 1.968 mg/L 3compartmentss NA 95% Rat Human +DTXSID3075204 Css NA 0.24 mg/L PBTK NA 50% Rat Human +DTXSID3075204 Css NA 1.29 mg/L PBTK NA 95% Rat Human +DTXSID30861722 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30861722 Fup 0.76 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30861722 Vd NA 0.9606 L/kg 1compartment NA NA Human Human +DTXSID30861722 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30861722 TK.Half.Life NA 8.185 hours 1compartment NA NA Human Human +DTXSID30861722 Css NA 0.8444 mg/L 3compartmentss NA 50% Human Human +DTXSID30861722 Css NA 5.326 mg/L 3compartmentss NA 95% Human Human +DTXSID30861722 Css NA 0.7172 mg/L PBTK NA 50% Human Human +DTXSID30861722 Css NA 3.5 mg/L PBTK NA 95% Human Human +DTXSID30861722 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30861722 Fup 0.76 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30861722 Vd NA 0.9829 L/kg 1compartment NA NA Rat Human +DTXSID30861722 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30861722 TK.Half.Life NA 2.851 hours 1compartment NA NA Rat Human +DTXSID30861722 Css NA 0.01592 mg/L 3compartmentss NA 50% Rat Human +DTXSID30861722 Css NA 0.1286 mg/L 3compartmentss NA 95% Rat Human +DTXSID30861722 Css NA 0.01308 mg/L PBTK NA 50% Rat Human +DTXSID30861722 Css NA 0.08403 mg/L PBTK NA 95% Rat Human +DTXSID30865361 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30865361 Fup 0.81 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30865361 Vd NA 0.5845 L/kg 1compartment NA NA Human Human +DTXSID30865361 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30865361 TK.Half.Life NA 4.674 hours 1compartment NA NA Human Human +DTXSID30865361 Css NA 1 mg/L 3compartmentss NA 50% Human Human +DTXSID30865361 Css NA 5.853 mg/L 3compartmentss NA 95% Human Human +DTXSID30865361 Css NA 0.7842 mg/L PBTK NA 50% Human Human +DTXSID30865361 Css NA 3.696 mg/L PBTK NA 95% Human Human +DTXSID30865361 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30865361 Fup 0.81 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30865361 Vd NA 0.5917 L/kg 1compartment NA NA Rat Human +DTXSID30865361 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30865361 TK.Half.Life NA 1.611 hours 1compartment NA NA Rat Human +DTXSID30865361 Css NA 0.0596 mg/L 3compartmentss NA 50% Rat Human +DTXSID30865361 Css NA 0.3401 mg/L 3compartmentss NA 95% Rat Human +DTXSID30865361 Css NA 0.0466 mg/L PBTK NA 50% Rat Human +DTXSID30865361 Css NA 0.2068 mg/L PBTK NA 95% Rat Human DTXSID30865801 Clint 173 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID30865801 Fup 0.0501 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID30865801 Vd NA 0.7332 L/kg 1compartment NA NA Human Human +DTXSID30865801 Vd NA 0.9056 L/kg 1compartment NA NA Human Human DTXSID30865801 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID30865801 TK.Half.Life NA 0.9864 hours 1compartment NA NA Human Human -DTXSID30865801 Css NA 0.06122 mg/L 3compartmentss NA 50% Human Human -DTXSID30865801 Css NA 0.5026 mg/L 3compartmentss NA 95% Human Human -DTXSID30865801 Css NA 0.03818 mg/L PBTK NA 50% Human Human -DTXSID30865801 Css NA 0.3017 mg/L PBTK NA 95% Human Human +DTXSID30865801 TK.Half.Life NA 1.215 hours 1compartment NA NA Human Human +DTXSID30865801 Css NA 0.0571 mg/L 3compartmentss NA 50% Human Human +DTXSID30865801 Css NA 0.4839 mg/L 3compartmentss NA 95% Human Human +DTXSID30865801 Css NA 0.03603 mg/L PBTK NA 50% Human Human +DTXSID30865801 Css NA 0.2962 mg/L PBTK NA 95% Human Human DTXSID30865801 Clint 173 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID30865801 Fup 0.0501 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID30865801 Vd NA 0.5735 L/kg 1compartment NA NA Rat Human +DTXSID30865801 Vd NA 0.6956 L/kg 1compartment NA NA Rat Human DTXSID30865801 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID30865801 TK.Half.Life NA 0.3921 hours 1compartment NA NA Rat Human -DTXSID30865801 Css NA 0.03534 mg/L 3compartmentss NA 50% Rat Human -DTXSID30865801 Css NA 0.2231 mg/L 3compartmentss NA 95% Rat Human -DTXSID30865801 Css NA 0.0207 mg/L PBTK NA 50% Rat Human -DTXSID30865801 Css NA 0.1288 mg/L PBTK NA 95% Rat Human +DTXSID30865801 TK.Half.Life NA 0.4687 hours 1compartment NA NA Rat Human +DTXSID30865801 Css NA 0.00778 mg/L 3compartmentss NA 50% Rat Human +DTXSID30865801 Css NA 0.05054 mg/L 3compartmentss NA 95% Rat Human +DTXSID30865801 Css NA 0.004792 mg/L PBTK NA 50% Rat Human +DTXSID30865801 Css NA 0.03019 mg/L PBTK NA 95% Rat Human DTXSID30866414 Clint 15.8 NA uL/min/million hepatocytes NA https://doi.org/10.3109/00498254.2012.669080 NA Human Human DTXSID30866414 Fup 0.176 NA NA https://doi.org/10.3109/00498254.2012.669080 NA Human Human -DTXSID30866414 Vd NA 3.26 L/kg 1compartment NA NA Human Human +DTXSID30866414 Vd NA 3.015 L/kg 1compartment NA NA Human Human DTXSID30866414 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID30866414 TK.Half.Life NA 5.127 hours 1compartment NA NA Human Human -DTXSID30866414 Css NA 0.1016 mg/L 3compartmentss NA 50% Human Human -DTXSID30866414 Css NA 0.7308 mg/L 3compartmentss NA 95% Human Human -DTXSID30866414 Css NA 0.08107 mg/L PBTK NA 50% Human Human -DTXSID30866414 Css NA 0.5319 mg/L PBTK NA 95% Human Human +DTXSID30866414 TK.Half.Life NA 8.544 hours 1compartment NA NA Human Human +DTXSID30866414 Css NA 0.2315 mg/L 3compartmentss NA 50% Human Human +DTXSID30866414 Css NA 1.349 mg/L 3compartmentss NA 95% Human Human +DTXSID30866414 Css NA 0.185 mg/L PBTK NA 50% Human Human +DTXSID30866414 Css NA 1.078 mg/L PBTK NA 95% Human Human DTXSID30866414 Clint 15.8 NA uL/min/million hepatocytes NA https://doi.org/10.3109/00498254.2012.669080 NA Rat Human DTXSID30866414 Fup 0.176 NA NA https://doi.org/10.3109/00498254.2012.669080 NA Rat Human -DTXSID30866414 Vd NA 3.275 L/kg 1compartment NA NA Rat Human +DTXSID30866414 Vd NA 2.536 L/kg 1compartment NA NA Rat Human DTXSID30866414 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID30866414 TK.Half.Life NA 2.898 hours 1compartment NA NA Rat Human -DTXSID30866414 Css NA 0.05502 mg/L 3compartmentss NA 50% Rat Human -DTXSID30866414 Css NA 0.309 mg/L 3compartmentss NA 95% Rat Human -DTXSID30866414 Css NA 0.04242 mg/L PBTK NA 50% Rat Human -DTXSID30866414 Css NA 0.2125 mg/L PBTK NA 95% Rat Human -DTXSID401009875 Clint NA 207.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID401009875 Fup NA 0.0539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID401009875 Vd NA 0.786 L/kg 1compartment NA NA Human Human -DTXSID401009875 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID401009875 TK.Half.Life NA 0.9786 hours 1compartment NA NA Human Human -DTXSID401009875 Css NA 0.0617 mg/L 3compartmentss NA 50% Human Human -DTXSID401009875 Css NA 0.5137 mg/L 3compartmentss NA 95% Human Human -DTXSID401009875 Css NA 0.03827 mg/L PBTK NA 50% Human Human -DTXSID401009875 Css NA 0.3072 mg/L PBTK NA 95% Human Human -DTXSID401009875 Clint NA 207.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID401009875 Fup NA 0.0539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID401009875 Vd NA 0.6131 L/kg 1compartment NA NA Rat Human -DTXSID401009875 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID401009875 TK.Half.Life NA 0.3781 hours 1compartment NA NA Rat Human -DTXSID401009875 Css NA 0.03489 mg/L 3compartmentss NA 50% Rat Human -DTXSID401009875 Css NA 0.2485 mg/L 3compartmentss NA 95% Rat Human -DTXSID401009875 Css NA 0.02026 mg/L PBTK NA 50% Rat Human -DTXSID401009875 Css NA 0.1402 mg/L PBTK NA 95% Rat Human -DTXSID401017163 Clint NA 93.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID401017163 Fup NA 0.0369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID401017163 Vd NA 2.834 L/kg 1compartment NA NA Human Human -DTXSID401017163 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID401017163 TK.Half.Life NA 9.602 hours 1compartment NA NA Human Human -DTXSID401017163 Css NA 0.355 mg/L 3compartmentss NA 50% Human Human -DTXSID401017163 Css NA 2.402 mg/L 3compartmentss NA 95% Human Human -DTXSID401017163 Css NA 0.2424 mg/L PBTK NA 50% Human Human -DTXSID401017163 Css NA 1.6 mg/L PBTK NA 95% Human Human -DTXSID401017163 Clint NA 93.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID401017163 Fup NA 0.0369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID401017163 Vd NA 2.125 L/kg 1compartment NA NA Rat Human -DTXSID401017163 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID401017163 TK.Half.Life NA 2.121 hours 1compartment NA NA Rat Human -DTXSID401017163 Css NA 0.2015 mg/L 3compartmentss NA 50% Rat Human -DTXSID401017163 Css NA 1.11 mg/L 3compartmentss NA 95% Rat Human -DTXSID401017163 Css NA 0.1315 mg/L PBTK NA 50% Rat Human -DTXSID401017163 Css NA 0.705 mg/L PBTK NA 95% Rat Human +DTXSID30866414 TK.Half.Life NA 2.822 hours 1compartment NA NA Rat Human +DTXSID30866414 Css NA 0.02806 mg/L 3compartmentss NA 50% Rat Human +DTXSID30866414 Css NA 0.1294 mg/L 3compartmentss NA 95% Rat Human +DTXSID30866414 Css NA 0.02325 mg/L PBTK NA 50% Rat Human +DTXSID30866414 Css NA 0.1072 mg/L PBTK NA 95% Rat Human +DTXSID30866550 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30866550 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30866550 Vd NA 2.25 L/kg 1compartment NA NA Human Human +DTXSID30866550 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30866550 TK.Half.Life NA 5.7 hours 1compartment NA NA Human Human +DTXSID30866550 Css NA 0.1614 mg/L 3compartmentss NA 50% Human Human +DTXSID30866550 Css NA 1.15 mg/L 3compartmentss NA 95% Human Human +DTXSID30866550 Css NA 0.1502 mg/L PBTK NA 50% Human Human +DTXSID30866550 Css NA 0.8825 mg/L PBTK NA 95% Human Human +DTXSID30866550 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30866550 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30866550 Vd NA 2.239 L/kg 1compartment NA NA Rat Human +DTXSID30866550 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30866550 TK.Half.Life NA 3.274 hours 1compartment NA NA Rat Human +DTXSID30866550 Css NA 0.006911 mg/L 3compartmentss NA 50% Rat Human +DTXSID30866550 Css NA 0.0562 mg/L 3compartmentss NA 95% Rat Human +DTXSID30866550 Css NA 0.006595 mg/L PBTK NA 50% Rat Human +DTXSID30866550 Css NA 0.04389 mg/L PBTK NA 95% Rat Human +DTXSID30868236 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30868236 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30868236 Vd NA 1.057 L/kg 1compartment NA NA Human Human +DTXSID30868236 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30868236 TK.Half.Life NA 1.183 hours 1compartment NA NA Human Human +DTXSID30868236 Css NA 0.0816 mg/L 3compartmentss NA 50% Human Human +DTXSID30868236 Css NA 0.7149 mg/L 3compartmentss NA 95% Human Human +DTXSID30868236 Css NA 0.0694 mg/L PBTK NA 50% Human Human +DTXSID30868236 Css NA 0.4981 mg/L PBTK NA 95% Human Human +DTXSID30868236 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30868236 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30868236 Vd NA 1.077 L/kg 1compartment NA NA Rat Human +DTXSID30868236 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30868236 TK.Half.Life NA 0.6342 hours 1compartment NA NA Rat Human +DTXSID30868236 Css NA 0.008846 mg/L 3compartmentss NA 50% Rat Human +DTXSID30868236 Css NA 0.06125 mg/L 3compartmentss NA 95% Rat Human +DTXSID30868236 Css NA 0.007813 mg/L PBTK NA 50% Rat Human +DTXSID30868236 Css NA 0.04064 mg/L PBTK NA 95% Rat Human +DTXSID30869521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30869521 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30869521 Vd NA 2.811 L/kg 1compartment NA NA Human Human +DTXSID30869521 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID30869521 TK.Half.Life NA 68.29 hours 1compartment NA NA Human Human +DTXSID30869521 Css NA 2.898 mg/L 3compartmentss NA 50% Human Human +DTXSID30869521 Css NA 20.13 mg/L 3compartmentss NA 95% Human Human +DTXSID30869521 Css NA 1.947 mg/L PBTK NA 50% Human Human +DTXSID30869521 Css NA 13.13 mg/L PBTK NA 95% Human Human +DTXSID30869521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30869521 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30869521 Vd NA 2.1 L/kg 1compartment NA NA Rat Human +DTXSID30869521 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID30869521 TK.Half.Life NA 13.08 hours 1compartment NA NA Rat Human +DTXSID30869521 Css NA 0.1487 mg/L 3compartmentss NA 50% Rat Human +DTXSID30869521 Css NA 1.06 mg/L 3compartmentss NA 95% Rat Human +DTXSID30869521 Css NA 0.09698 mg/L PBTK NA 50% Rat Human +DTXSID30869521 Css NA 0.6637 mg/L PBTK NA 95% Rat Human +DTXSID30870132 Clint 3.2 NA uL/min/million hepatocytes NA Yamagata 2017 NA Human Human +DTXSID30870132 Fup 0.28 NA NA Yamagata 2017 NA Human Human +DTXSID30870132 Vd NA 0.3127 L/kg 1compartment NA NA Human Human +DTXSID30870132 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30870132 TK.Half.Life NA 1.28 hours 1compartment NA NA Human Human +DTXSID30870132 Css NA 0.1805 mg/L 3compartmentss NA 50% Human Human +DTXSID30870132 Css NA 0.9873 mg/L 3compartmentss NA 95% Human Human +DTXSID30870132 Css NA 0.1619 mg/L PBTK NA 50% Human Human +DTXSID30870132 Css NA 0.8879 mg/L PBTK NA 95% Human Human +DTXSID30870132 Clint 3.2 NA uL/min/million hepatocytes NA Yamagata 2017 NA Rat Human +DTXSID30870132 Fup 0.28 NA NA Yamagata 2017 NA Rat Human +DTXSID30870132 Vd NA 0.3197 L/kg 1compartment NA NA Rat Human +DTXSID30870132 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30870132 TK.Half.Life NA 0.7481 hours 1compartment NA NA Rat Human +DTXSID30870132 Css NA 0.001577 mg/L 3compartmentss NA 50% Rat Human +DTXSID30870132 Css NA 0.007285 mg/L 3compartmentss NA 95% Rat Human +DTXSID30870132 Css NA 0.001423 mg/L PBTK NA 50% Rat Human +DTXSID30870132 Css NA 0.006577 mg/L PBTK NA 95% Rat Human +DTXSID30871200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30871200 Fup 0.0367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30871200 Vd NA 3.056 L/kg 1compartment NA NA Human Human +DTXSID30871200 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID30871200 TK.Half.Life NA 58.54 hours 1compartment NA NA Human Human +DTXSID30871200 Css NA 2.295 mg/L 3compartmentss NA 50% Human Human +DTXSID30871200 Css NA 14.81 mg/L 3compartmentss NA 95% Human Human +DTXSID30871200 Css NA 1.583 mg/L PBTK NA 50% Human Human +DTXSID30871200 Css NA 9.924 mg/L PBTK NA 95% Human Human +DTXSID30871200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30871200 Fup 0.0367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30871200 Vd NA 2.29 L/kg 1compartment NA NA Rat Human +DTXSID30871200 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID30871200 TK.Half.Life NA 8.745 hours 1compartment NA NA Rat Human +DTXSID30871200 Css NA 0.2961 mg/L 3compartmentss NA 50% Rat Human +DTXSID30871200 Css NA 1.722 mg/L 3compartmentss NA 95% Rat Human +DTXSID30871200 Css NA 0.2028 mg/L PBTK NA 50% Rat Human +DTXSID30871200 Css NA 1.141 mg/L PBTK NA 95% Rat Human +DTXSID30873365 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30873365 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30873365 Vd NA 19.99 L/kg 1compartment NA NA Human Human +DTXSID30873365 Days.Css NA 63 Days PBTK NA NA Human Human +DTXSID30873365 TK.Half.Life NA 290.1 hours 1compartment NA NA Human Human +DTXSID30873365 Css NA 0.1982 mg/L 3compartmentss NA 50% Human Human +DTXSID30873365 Css NA 2.036 mg/L 3compartmentss NA 95% Human Human +DTXSID30873365 Css NA 1.178 mg/L PBTK NA 50% Human Human +DTXSID30873365 Css NA 4.707 mg/L PBTK NA 95% Human Human +DTXSID30873365 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30873365 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30873365 Vd NA 1.706 L/kg 1compartment NA NA Rat Human +DTXSID30873365 Days.Css NA 53 Days PBTK NA NA Rat Human +DTXSID30873365 TK.Half.Life NA 221.3 hours 1compartment NA NA Rat Human +DTXSID30873365 Css NA 3.165 mg/L 3compartmentss NA 50% Rat Human +DTXSID30873365 Css NA 20.27 mg/L 3compartmentss NA 95% Rat Human +DTXSID30873365 Css NA 2.363 mg/L PBTK NA 50% Rat Human +DTXSID30873365 Css NA 12.09 mg/L PBTK NA 95% Rat Human +DTXSID30873385 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30873385 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30873385 Vd NA 0.4433 L/kg 1compartment NA NA Human Human +DTXSID30873385 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID30873385 TK.Half.Life NA 22.35 hours 1compartment NA NA Human Human +DTXSID30873385 Css NA 6.389 mg/L 3compartmentss NA 50% Human Human +DTXSID30873385 Css NA 30.72 mg/L 3compartmentss NA 95% Human Human +DTXSID30873385 Css NA 4.028 mg/L PBTK NA 50% Human Human +DTXSID30873385 Css NA 18.45 mg/L PBTK NA 95% Human Human +DTXSID30873385 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30873385 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30873385 Vd NA 0.3983 L/kg 1compartment NA NA Rat Human +DTXSID30873385 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30873385 TK.Half.Life NA 6.776 hours 1compartment NA NA Rat Human +DTXSID30873385 Css NA 0.1536 mg/L 3compartmentss NA 50% Rat Human +DTXSID30873385 Css NA 0.9887 mg/L 3compartmentss NA 95% Rat Human +DTXSID30873385 Css NA 0.09424 mg/L PBTK NA 50% Rat Human +DTXSID30873385 Css NA 0.571 mg/L PBTK NA 95% Rat Human +DTXSID30880630 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880630 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880630 Vd NA 0.7254 L/kg 1compartment NA NA Human Human +DTXSID30880630 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30880630 TK.Half.Life NA 0.7526 hours 1compartment NA NA Human Human +DTXSID30880630 Css NA 0.0417 mg/L 3compartmentss NA 50% Human Human +DTXSID30880630 Css NA 0.3446 mg/L 3compartmentss NA 95% Human Human +DTXSID30880630 Css NA 0.03166 mg/L PBTK NA 50% Human Human +DTXSID30880630 Css NA 0.2406 mg/L PBTK NA 95% Human Human +DTXSID30880630 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880630 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880630 Vd NA 0.7004 L/kg 1compartment NA NA Rat Human +DTXSID30880630 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30880630 TK.Half.Life NA 0.3687 hours 1compartment NA NA Rat Human +DTXSID30880630 Css NA 0.005098 mg/L 3compartmentss NA 50% Rat Human +DTXSID30880630 Css NA 0.03493 mg/L 3compartmentss NA 95% Rat Human +DTXSID30880630 Css NA 0.003923 mg/L PBTK NA 50% Rat Human +DTXSID30880630 Css NA 0.02401 mg/L PBTK NA 95% Rat Human +DTXSID30880635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880635 Fup 0.04 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880635 Vd NA 31.26 L/kg 1compartment NA NA Human Human +DTXSID30880635 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID30880635 TK.Half.Life NA 46.12 hours 1compartment NA NA Human Human +DTXSID30880635 Css NA 0.01765 mg/L 3compartmentss NA 50% Human Human +DTXSID30880635 Css NA 0.1738 mg/L 3compartmentss NA 95% Human Human +DTXSID30880635 Css NA 0.05761 mg/L PBTK NA 50% Human Human +DTXSID30880635 Css NA 0.4393 mg/L PBTK NA 95% Human Human +DTXSID30880635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880635 Fup 0.04 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880635 Vd NA 26.01 L/kg 1compartment NA NA Rat Human +DTXSID30880635 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID30880635 TK.Half.Life NA 8.907 hours 1compartment NA NA Rat Human +DTXSID30880635 Css NA 0.000164 mg/L 3compartmentss NA 50% Rat Human +DTXSID30880635 Css NA 0.001606 mg/L 3compartmentss NA 95% Rat Human +DTXSID30880635 Css NA 0.0005688 mg/L PBTK NA 50% Rat Human +DTXSID30880635 Css NA 0.004333 mg/L PBTK NA 95% Rat Human +DTXSID30880690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880690 Fup 0.023 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880690 Vd NA 2.024 L/kg 1compartment NA NA Human Human +DTXSID30880690 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID30880690 TK.Half.Life NA 18.63 hours 1compartment NA NA Human Human +DTXSID30880690 Css NA 1.321 mg/L 3compartmentss NA 50% Human Human +DTXSID30880690 Css NA 11.48 mg/L 3compartmentss NA 95% Human Human +DTXSID30880690 Css NA 0.8578 mg/L PBTK NA 50% Human Human +DTXSID30880690 Css NA 7.124 mg/L PBTK NA 95% Human Human +DTXSID30880690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880690 Fup 0.023 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880690 Vd NA 1.526 L/kg 1compartment NA NA Rat Human +DTXSID30880690 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30880690 TK.Half.Life NA 6.167 hours 1compartment NA NA Rat Human +DTXSID30880690 Css NA 0.1744 mg/L 3compartmentss NA 50% Rat Human +DTXSID30880690 Css NA 1.164 mg/L 3compartmentss NA 95% Rat Human +DTXSID30880690 Css NA 0.1105 mg/L PBTK NA 50% Rat Human +DTXSID30880690 Css NA 0.7014 mg/L PBTK NA 95% Rat Human +DTXSID30880711 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880711 Fup 0.0279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880711 Vd NA 2.952 L/kg 1compartment NA NA Human Human +DTXSID30880711 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID30880711 TK.Half.Life NA 48.3 hours 1compartment NA NA Human Human +DTXSID30880711 Css NA 2.037 mg/L 3compartmentss NA 50% Human Human +DTXSID30880711 Css NA 13.41 mg/L 3compartmentss NA 95% Human Human +DTXSID30880711 Css NA 1.396 mg/L PBTK NA 50% Human Human +DTXSID30880711 Css NA 8.862 mg/L PBTK NA 95% Human Human +DTXSID30880711 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880711 Fup 0.0279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880711 Vd NA 2.209 L/kg 1compartment NA NA Rat Human +DTXSID30880711 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID30880711 TK.Half.Life NA 8.188 hours 1compartment NA NA Rat Human +DTXSID30880711 Css NA 0.2635 mg/L 3compartmentss NA 50% Rat Human +DTXSID30880711 Css NA 1.521 mg/L 3compartmentss NA 95% Rat Human +DTXSID30880711 Css NA 0.1784 mg/L PBTK NA 50% Rat Human +DTXSID30880711 Css NA 0.9988 mg/L PBTK NA 95% Rat Human +DTXSID30880812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880812 Fup 0.00708 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880812 Vd NA 6.817 L/kg 1compartment NA NA Human Human +DTXSID30880812 Days.Css NA 40 Days PBTK NA NA Human Human +DTXSID30880812 TK.Half.Life NA 206.5 hours 1compartment NA NA Human Human +DTXSID30880812 Css NA 1.415 mg/L 3compartmentss NA 50% Human Human +DTXSID30880812 Css NA 8.94 mg/L 3compartmentss NA 95% Human Human +DTXSID30880812 Css NA 1.331 mg/L PBTK NA 50% Human Human +DTXSID30880812 Css NA 8.219 mg/L PBTK NA 95% Human Human +DTXSID30880812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880812 Fup 0.00708 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880812 Vd NA 5.277 L/kg 1compartment NA NA Rat Human +DTXSID30880812 Days.Css NA 24 Days PBTK NA NA Rat Human +DTXSID30880812 TK.Half.Life NA 29.17 hours 1compartment NA NA Rat Human +DTXSID30880812 Css NA 0.01518 mg/L 3compartmentss NA 50% Rat Human +DTXSID30880812 Css NA 0.08751 mg/L 3compartmentss NA 95% Rat Human +DTXSID30880812 Css NA 0.01408 mg/L PBTK NA 50% Rat Human +DTXSID30880812 Css NA 0.08124 mg/L PBTK NA 95% Rat Human +DTXSID30880892 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880892 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880892 Vd NA 2.146 L/kg 1compartment NA NA Human Human +DTXSID30880892 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30880892 TK.Half.Life NA 3.328 hours 1compartment NA NA Human Human +DTXSID30880892 Css NA 0.09586 mg/L 3compartmentss NA 50% Human Human +DTXSID30880892 Css NA 0.652 mg/L 3compartmentss NA 95% Human Human +DTXSID30880892 Css NA 0.074 mg/L PBTK NA 50% Human Human +DTXSID30880892 Css NA 0.4637 mg/L PBTK NA 95% Human Human +DTXSID30880892 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880892 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880892 Vd NA 1.678 L/kg 1compartment NA NA Rat Human +DTXSID30880892 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30880892 TK.Half.Life NA 1.114 hours 1compartment NA NA Rat Human +DTXSID30880892 Css NA 0.01198 mg/L 3compartmentss NA 50% Rat Human +DTXSID30880892 Css NA 0.06477 mg/L 3compartmentss NA 95% Rat Human +DTXSID30880892 Css NA 0.009246 mg/L PBTK NA 50% Rat Human +DTXSID30880892 Css NA 0.04639 mg/L PBTK NA 95% Rat Human +DTXSID30880918 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880918 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30880918 Vd NA 1.345 L/kg 1compartment NA NA Human Human +DTXSID30880918 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30880918 TK.Half.Life NA 3.253 hours 1compartment NA NA Human Human +DTXSID30880918 Css NA 0.2389 mg/L 3compartmentss NA 50% Human Human +DTXSID30880918 Css NA 1.799 mg/L 3compartmentss NA 95% Human Human +DTXSID30880918 Css NA 0.1598 mg/L PBTK NA 50% Human Human +DTXSID30880918 Css NA 1.158 mg/L PBTK NA 95% Human Human +DTXSID30880918 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880918 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30880918 Vd NA 1.044 L/kg 1compartment NA NA Rat Human +DTXSID30880918 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30880918 TK.Half.Life NA 1.313 hours 1compartment NA NA Rat Human +DTXSID30880918 Css NA 0.03089 mg/L 3compartmentss NA 50% Rat Human +DTXSID30880918 Css NA 0.1868 mg/L 3compartmentss NA 95% Rat Human +DTXSID30880918 Css NA 0.02028 mg/L PBTK NA 50% Rat Human +DTXSID30880918 Css NA 0.1133 mg/L PBTK NA 95% Rat Human +DTXSID30881203 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30881203 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30881203 Vd NA 2.292 L/kg 1compartment NA NA Human Human +DTXSID30881203 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30881203 TK.Half.Life NA 4.871 hours 1compartment NA NA Human Human +DTXSID30881203 Css NA 0.1615 mg/L 3compartmentss NA 50% Human Human +DTXSID30881203 Css NA 1.062 mg/L 3compartmentss NA 95% Human Human +DTXSID30881203 Css NA 0.1191 mg/L PBTK NA 50% Human Human +DTXSID30881203 Css NA 0.7393 mg/L PBTK NA 95% Human Human +DTXSID30881203 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30881203 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30881203 Vd NA 1.761 L/kg 1compartment NA NA Rat Human +DTXSID30881203 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30881203 TK.Half.Life NA 1.506 hours 1compartment NA NA Rat Human +DTXSID30881203 Css NA 0.02051 mg/L 3compartmentss NA 50% Rat Human +DTXSID30881203 Css NA 0.1024 mg/L 3compartmentss NA 95% Rat Human +DTXSID30881203 Css NA 0.01502 mg/L PBTK NA 50% Rat Human +DTXSID30881203 Css NA 0.07179 mg/L PBTK NA 95% Rat Human +DTXSID30881243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30881243 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30881243 Vd NA 3.072 L/kg 1compartment NA NA Human Human +DTXSID30881243 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID30881243 TK.Half.Life NA 29.8 hours 1compartment NA NA Human Human +DTXSID30881243 Css NA 1.057 mg/L 3compartmentss NA 50% Human Human +DTXSID30881243 Css NA 6.765 mg/L 3compartmentss NA 95% Human Human +DTXSID30881243 Css NA 0.7462 mg/L PBTK NA 50% Human Human +DTXSID30881243 Css NA 4.677 mg/L PBTK NA 95% Human Human +DTXSID30881243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30881243 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30881243 Vd NA 2.309 L/kg 1compartment NA NA Rat Human +DTXSID30881243 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID30881243 TK.Half.Life NA 4.649 hours 1compartment NA NA Rat Human +DTXSID30881243 Css NA 0.136 mg/L 3compartmentss NA 50% Rat Human +DTXSID30881243 Css NA 0.6994 mg/L 3compartmentss NA 95% Rat Human +DTXSID30881243 Css NA 0.09522 mg/L PBTK NA 50% Rat Human +DTXSID30881243 Css NA 0.4815 mg/L PBTK NA 95% Rat Human +DTXSID30892970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30892970 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30892970 Vd NA 0.9422 L/kg 1compartment NA NA Human Human +DTXSID30892970 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30892970 TK.Half.Life NA 1.798 hours 1compartment NA NA Human Human +DTXSID30892970 Css NA 0.1571 mg/L 3compartmentss NA 50% Human Human +DTXSID30892970 Css NA 1.309 mg/L 3compartmentss NA 95% Human Human +DTXSID30892970 Css NA 0.1089 mg/L PBTK NA 50% Human Human +DTXSID30892970 Css NA 0.8449 mg/L PBTK NA 95% Human Human +DTXSID30892970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30892970 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30892970 Vd NA 0.9253 L/kg 1compartment NA NA Rat Human +DTXSID30892970 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30892970 TK.Half.Life NA 1.015 hours 1compartment NA NA Rat Human +DTXSID30892970 Css NA 0.01938 mg/L 3compartmentss NA 50% Rat Human +DTXSID30892970 Css NA 0.1302 mg/L 3compartmentss NA 95% Rat Human +DTXSID30892970 Css NA 0.01323 mg/L PBTK NA 50% Rat Human +DTXSID30892970 Css NA 0.08131 mg/L PBTK NA 95% Rat Human +DTXSID30893700 Clint 1.121 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human +DTXSID30893700 Fup 0.674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30893700 Vd NA 0.5909 L/kg 1compartment NA NA Human Human +DTXSID30893700 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30893700 TK.Half.Life NA 2.142 hours 1compartment NA NA Human Human +DTXSID30893700 Css NA 0.3401 mg/L 3compartmentss NA 50% Human Human +DTXSID30893700 Css NA 2.441 mg/L 3compartmentss NA 95% Human Human +DTXSID30893700 Css NA 0.2697 mg/L PBTK NA 50% Human Human +DTXSID30893700 Css NA 1.554 mg/L PBTK NA 95% Human Human +DTXSID30893700 Clint 1.121 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human +DTXSID30893700 Fup 0.674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30893700 Vd NA 0.5981 L/kg 1compartment NA NA Rat Human +DTXSID30893700 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30893700 TK.Half.Life NA 1.065 hours 1compartment NA NA Rat Human +DTXSID30893700 Css NA 0.009588 mg/L 3compartmentss NA 50% Rat Human +DTXSID30893700 Css NA 0.08566 mg/L 3compartmentss NA 95% Rat Human +DTXSID30893700 Css NA 0.007399 mg/L PBTK NA 50% Rat Human +DTXSID30893700 Css NA 0.05423 mg/L PBTK NA 95% Rat Human +DTXSID30895042 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30895042 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30895042 Vd NA 2.295 L/kg 1compartment NA NA Human Human +DTXSID30895042 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30895042 TK.Half.Life NA 7.711 hours 1compartment NA NA Human Human +DTXSID30895042 Css NA 0.3502 mg/L 3compartmentss NA 50% Human Human +DTXSID30895042 Css NA 2.408 mg/L 3compartmentss NA 95% Human Human +DTXSID30895042 Css NA 0.2421 mg/L PBTK NA 50% Human Human +DTXSID30895042 Css NA 1.572 mg/L PBTK NA 95% Human Human +DTXSID30895042 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30895042 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30895042 Vd NA 1.738 L/kg 1compartment NA NA Rat Human +DTXSID30895042 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30895042 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human +DTXSID30895042 Css NA 0.04532 mg/L 3compartmentss NA 50% Rat Human +DTXSID30895042 Css NA 0.2466 mg/L 3compartmentss NA 95% Rat Human +DTXSID30895042 Css NA 0.03085 mg/L PBTK NA 50% Rat Human +DTXSID30895042 Css NA 0.1602 mg/L PBTK NA 95% Rat Human +DTXSID30960103 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30960103 Fup 0.367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30960103 Vd NA 0.6812 L/kg 1compartment NA NA Human Human +DTXSID30960103 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID30960103 TK.Half.Life NA 12.13 hours 1compartment NA NA Human Human +DTXSID30960103 Css NA 1.355 mg/L 3compartmentss NA 50% Human Human +DTXSID30960103 Css NA 6.02 mg/L 3compartmentss NA 95% Human Human +DTXSID30960103 Css NA 1.009 mg/L PBTK NA 50% Human Human +DTXSID30960103 Css NA 3.865 mg/L PBTK NA 95% Human Human +DTXSID30960103 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30960103 Fup 0.367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30960103 Vd NA 0.664 L/kg 1compartment NA NA Rat Human +DTXSID30960103 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30960103 TK.Half.Life NA 4 hours 1compartment NA NA Rat Human +DTXSID30960103 Css NA 0.01038 mg/L 3compartmentss NA 50% Rat Human +DTXSID30960103 Css NA 0.06647 mg/L 3compartmentss NA 95% Rat Human +DTXSID30960103 Css NA 0.007356 mg/L PBTK NA 50% Rat Human +DTXSID30960103 Css NA 0.04312 mg/L PBTK NA 95% Rat Human +DTXSID30974109 Clint 3.8 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30974109 Fup 0.0484 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30974109 Vd NA 1.402 L/kg 1compartment NA NA Human Human +DTXSID30974109 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID30974109 TK.Half.Life NA 29.14 hours 1compartment NA NA Human Human +DTXSID30974109 Css NA 3.23 mg/L 3compartmentss NA 50% Human Human +DTXSID30974109 Css NA 20.5 mg/L 3compartmentss NA 95% Human Human +DTXSID30974109 Css NA 2.063 mg/L PBTK NA 50% Human Human +DTXSID30974109 Css NA 12.38 mg/L PBTK NA 95% Human Human +DTXSID30974109 Clint 3.8 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30974109 Fup 0.0484 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30974109 Vd NA 1.055 L/kg 1compartment NA NA Rat Human +DTXSID30974109 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID30974109 TK.Half.Life NA 10.93 hours 1compartment NA NA Rat Human +DTXSID30974109 Css NA 0.3886 mg/L 3compartmentss NA 50% Rat Human +DTXSID30974109 Css NA 1.787 mg/L 3compartmentss NA 95% Rat Human +DTXSID30974109 Css NA 0.24 mg/L PBTK NA 50% Rat Human +DTXSID30974109 Css NA 1.049 mg/L PBTK NA 95% Rat Human +DTXSID30976289 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID30976289 Fup 0.32 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID30976289 Vd NA 0.758 L/kg 1compartment NA NA Human Human +DTXSID30976289 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID30976289 TK.Half.Life NA 1.838 hours 1compartment NA NA Human Human +DTXSID30976289 Css NA 0.1782 mg/L 3compartmentss NA 50% Human Human +DTXSID30976289 Css NA 1.202 mg/L 3compartmentss NA 95% Human Human +DTXSID30976289 Css NA 0.131 mg/L PBTK NA 50% Human Human +DTXSID30976289 Css NA 0.7921 mg/L PBTK NA 95% Human Human +DTXSID30976289 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID30976289 Fup 0.32 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID30976289 Vd NA 0.6935 L/kg 1compartment NA NA Rat Human +DTXSID30976289 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID30976289 TK.Half.Life NA 0.9431 hours 1compartment NA NA Rat Human +DTXSID30976289 Css NA 0.00776 mg/L 3compartmentss NA 50% Rat Human +DTXSID30976289 Css NA 0.05841 mg/L 3compartmentss NA 95% Rat Human +DTXSID30976289 Css NA 0.005636 mg/L PBTK NA 50% Rat Human +DTXSID30976289 Css NA 0.0381 mg/L PBTK NA 95% Rat Human +DTXSID401017163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401017163 Fup 0.0369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401017163 Vd NA 3.051 L/kg 1compartment NA NA Human Human +DTXSID401017163 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID401017163 TK.Half.Life NA 56.08 hours 1compartment NA NA Human Human +DTXSID401017163 Css NA 1.954 mg/L 3compartmentss NA 50% Human Human +DTXSID401017163 Css NA 12.71 mg/L 3compartmentss NA 95% Human Human +DTXSID401017163 Css NA 1.355 mg/L PBTK NA 50% Human Human +DTXSID401017163 Css NA 8.496 mg/L PBTK NA 95% Human Human +DTXSID401017163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401017163 Fup 0.0369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401017163 Vd NA 2.288 L/kg 1compartment NA NA Rat Human +DTXSID401017163 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID401017163 TK.Half.Life NA 8.522 hours 1compartment NA NA Rat Human +DTXSID401017163 Css NA 0.09758 mg/L 3compartmentss NA 50% Rat Human +DTXSID401017163 Css NA 0.6667 mg/L 3compartmentss NA 95% Rat Human +DTXSID401017163 Css NA 0.06596 mg/L PBTK NA 50% Rat Human +DTXSID401017163 Css NA 0.4273 mg/L PBTK NA 95% Rat Human +DTXSID401100653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401100653 Fup 0.0397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401100653 Vd NA 2.802 L/kg 1compartment NA NA Human Human +DTXSID401100653 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID401100653 TK.Half.Life NA 26.3 hours 1compartment NA NA Human Human +DTXSID401100653 Css NA 1.066 mg/L 3compartmentss NA 50% Human Human +DTXSID401100653 Css NA 7.856 mg/L 3compartmentss NA 95% Human Human +DTXSID401100653 Css NA 0.7326 mg/L PBTK NA 50% Human Human +DTXSID401100653 Css NA 5.143 mg/L PBTK NA 95% Human Human +DTXSID401100653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401100653 Fup 0.0397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401100653 Vd NA 2.146 L/kg 1compartment NA NA Rat Human +DTXSID401100653 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID401100653 TK.Half.Life NA 6.043 hours 1compartment NA NA Rat Human +DTXSID401100653 Css NA 0.05776 mg/L 3compartmentss NA 50% Rat Human +DTXSID401100653 Css NA 0.4167 mg/L 3compartmentss NA 95% Rat Human +DTXSID401100653 Css NA 0.03882 mg/L PBTK NA 50% Rat Human +DTXSID401100653 Css NA 0.261 mg/L PBTK NA 95% Rat Human +DTXSID40110071 Clint 3.91 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40110071 Fup 0.346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40110071 Vd NA 1.45 L/kg 1compartment NA NA Human Human +DTXSID40110071 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40110071 TK.Half.Life NA 4.316 hours 1compartment NA NA Human Human +DTXSID40110071 Css NA 0.216 mg/L 3compartmentss NA 50% Human Human +DTXSID40110071 Css NA 1.401 mg/L 3compartmentss NA 95% Human Human +DTXSID40110071 Css NA 0.1819 mg/L PBTK NA 50% Human Human +DTXSID40110071 Css NA 1.001 mg/L PBTK NA 95% Human Human +DTXSID40110071 Clint 3.91 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40110071 Fup 0.346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40110071 Vd NA 1.458 L/kg 1compartment NA NA Rat Human +DTXSID40110071 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40110071 TK.Half.Life NA 2.472 hours 1compartment NA NA Rat Human +DTXSID40110071 Css NA 0.008879 mg/L 3compartmentss NA 50% Rat Human +DTXSID40110071 Css NA 0.0666 mg/L 3compartmentss NA 95% Rat Human +DTXSID40110071 Css NA 0.007622 mg/L PBTK NA 50% Rat Human +DTXSID40110071 Css NA 0.04753 mg/L PBTK NA 95% Rat Human +DTXSID401105722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401105722 Fup 0.0885 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401105722 Vd NA 0.316 L/kg 1compartment NA NA Human Human +DTXSID401105722 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID401105722 TK.Half.Life NA 0.8925 hours 1compartment NA NA Human Human +DTXSID401105722 Css NA 0.1306 mg/L 3compartmentss NA 50% Human Human +DTXSID401105722 Css NA 1.226 mg/L 3compartmentss NA 95% Human Human +DTXSID401105722 Css NA 0.08076 mg/L PBTK NA 50% Human Human +DTXSID401105722 Css NA 0.7256 mg/L PBTK NA 95% Human Human +DTXSID401105722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401105722 Fup 0.0885 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401105722 Vd NA 0.299 L/kg 1compartment NA NA Rat Human +DTXSID401105722 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID401105722 TK.Half.Life NA 0.5067 hours 1compartment NA NA Rat Human +DTXSID401105722 Css NA 0.001201 mg/L 3compartmentss NA 50% Rat Human +DTXSID401105722 Css NA 0.009061 mg/L 3compartmentss NA 95% Rat Human +DTXSID401105722 Css NA 0.0006967 mg/L PBTK NA 50% Rat Human +DTXSID401105722 Css NA 0.005094 mg/L PBTK NA 95% Rat Human +DTXSID401108938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401108938 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401108938 Vd NA 1.171 L/kg 1compartment NA NA Human Human +DTXSID401108938 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID401108938 TK.Half.Life NA 3.096 hours 1compartment NA NA Human Human +DTXSID401108938 Css NA 0.2794 mg/L 3compartmentss NA 50% Human Human +DTXSID401108938 Css NA 2.241 mg/L 3compartmentss NA 95% Human Human +DTXSID401108938 Css NA 0.1834 mg/L PBTK NA 50% Human Human +DTXSID401108938 Css NA 1.372 mg/L PBTK NA 95% Human Human +DTXSID401108938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401108938 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401108938 Vd NA 0.9125 L/kg 1compartment NA NA Rat Human +DTXSID401108938 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID401108938 TK.Half.Life NA 1.305 hours 1compartment NA NA Rat Human +DTXSID401108938 Css NA 0.03367 mg/L 3compartmentss NA 50% Rat Human +DTXSID401108938 Css NA 0.2043 mg/L 3compartmentss NA 95% Rat Human +DTXSID401108938 Css NA 0.02159 mg/L PBTK NA 50% Rat Human +DTXSID401108938 Css NA 0.1249 mg/L PBTK NA 95% Rat Human +DTXSID401313244 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401313244 Fup 0.0473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID401313244 Vd NA 0.5535 L/kg 1compartment NA NA Human Human +DTXSID401313244 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID401313244 TK.Half.Life NA 2.461 hours 1compartment NA NA Human Human +DTXSID401313244 Css NA 0.5874 mg/L 3compartmentss NA 50% Human Human +DTXSID401313244 Css NA 5.093 mg/L 3compartmentss NA 95% Human Human +DTXSID401313244 Css NA 0.3608 mg/L PBTK NA 50% Human Human +DTXSID401313244 Css NA 2.996 mg/L PBTK NA 95% Human Human +DTXSID401313244 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401313244 Fup 0.0473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID401313244 Vd NA 0.4421 L/kg 1compartment NA NA Rat Human +DTXSID401313244 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID401313244 TK.Half.Life NA 1.207 hours 1compartment NA NA Rat Human +DTXSID401313244 Css NA 0.04443 mg/L 3compartmentss NA 50% Rat Human +DTXSID401313244 Css NA 0.3341 mg/L 3compartmentss NA 95% Rat Human +DTXSID401313244 Css NA 0.02633 mg/L PBTK NA 50% Rat Human +DTXSID401313244 Css NA 0.1918 mg/L PBTK NA 95% Rat Human DTXSID40143768 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.31.5.580 NA Human Human DTXSID40143768 Fup 0.0191 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Human Human -DTXSID40143768 Vd NA 0.1741 L/kg 1compartment NA NA Human Human -DTXSID40143768 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID40143768 TK.Half.Life NA 58.99 hours 1compartment NA NA Human Human -DTXSID40143768 Css NA 56.94 mg/L 3compartmentss NA 50% Human Human -DTXSID40143768 Css NA 359 mg/L 3compartmentss NA 95% Human Human -DTXSID40143768 Css NA 34.39 mg/L PBTK NA 50% Human Human -DTXSID40143768 Css NA 206.8 mg/L PBTK NA 95% Human Human +DTXSID40143768 Vd NA 0.188 L/kg 1compartment NA NA Human Human +DTXSID40143768 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID40143768 TK.Half.Life NA 63.71 hours 1compartment NA NA Human Human +DTXSID40143768 Css NA 49.64 mg/L 3compartmentss NA 50% Human Human +DTXSID40143768 Css NA 304.8 mg/L 3compartmentss NA 95% Human Human +DTXSID40143768 Css NA 29.28 mg/L PBTK NA 50% Human Human +DTXSID40143768 Css NA 179.8 mg/L PBTK NA 95% Human Human DTXSID40143768 Clint 12.08 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID40143768 Fup 0.33 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat -DTXSID40143768 Vd NA 0.3529 L/kg 1compartment NA NA Rat Rat +DTXSID40143768 Vd NA 0.4606 L/kg 1compartment NA NA Rat Rat DTXSID40143768 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID40143768 TK.Half.Life NA 0.3241 hours 1compartment NA NA Rat Rat -DTXSID40143768 Css NA 0 mg/L 3compartmentss NA 50% Rat Rat -DTXSID40143768 Css NA 0 mg/L 3compartmentss NA 95% Rat Rat -DTXSID40143768 Css NA 0 mg/L PBTK NA 50% Rat Rat -DTXSID40143768 Css NA 0 mg/L PBTK NA 95% Rat Rat +DTXSID40143768 TK.Half.Life NA 0.4224 hours 1compartment NA NA Rat Rat +DTXSID40143768 Css NA 0.005021 mg/L 3compartmentss NA 50% Rat Rat +DTXSID40143768 Css NA 0.03815 mg/L 3compartmentss NA 95% Rat Rat +DTXSID40143768 Css NA 0.00301 mg/L PBTK NA 50% Rat Rat +DTXSID40143768 Css NA 0.02318 mg/L PBTK NA 95% Rat Rat +DTXSID40146032 Clint 3.327 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40146032 Fup 0.062 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40146032 Vd NA 1.723 L/kg 1compartment NA NA Human Human +DTXSID40146032 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40146032 TK.Half.Life NA 11.12 hours 1compartment NA NA Human Human +DTXSID40146032 Css NA 0.8101 mg/L 3compartmentss NA 50% Human Human +DTXSID40146032 Css NA 6.79 mg/L 3compartmentss NA 95% Human Human +DTXSID40146032 Css NA 0.6504 mg/L PBTK NA 50% Human Human +DTXSID40146032 Css NA 4.596 mg/L PBTK NA 95% Human Human +DTXSID40146032 Clint 3.327 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40146032 Fup 0.062 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40146032 Vd NA 1.676 L/kg 1compartment NA NA Rat Human +DTXSID40146032 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40146032 TK.Half.Life NA 6.822 hours 1compartment NA NA Rat Human +DTXSID40146032 Css NA 0.1017 mg/L 3compartmentss NA 50% Rat Human +DTXSID40146032 Css NA 0.6693 mg/L 3compartmentss NA 95% Rat Human +DTXSID40146032 Css NA 0.07998 mg/L PBTK NA 50% Rat Human +DTXSID40146032 Css NA 0.4353 mg/L PBTK NA 95% Rat Human +DTXSID40151606 Clint 6 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40151606 Fup 0.0336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40151606 Vd NA 0.7173 L/kg 1compartment NA NA Human Human +DTXSID40151606 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40151606 TK.Half.Life NA 12.63 hours 1compartment NA NA Human Human +DTXSID40151606 Css NA 2.675 mg/L 3compartmentss NA 50% Human Human +DTXSID40151606 Css NA 18.8 mg/L 3compartmentss NA 95% Human Human +DTXSID40151606 Css NA 1.634 mg/L PBTK NA 50% Human Human +DTXSID40151606 Css NA 11.09 mg/L PBTK NA 95% Human Human +DTXSID40151606 Clint 6 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40151606 Fup 0.0336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40151606 Vd NA 0.5494 L/kg 1compartment NA NA Rat Human +DTXSID40151606 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40151606 TK.Half.Life NA 5.786 hours 1compartment NA NA Rat Human +DTXSID40151606 Css NA 0.1269 mg/L 3compartmentss NA 50% Rat Human +DTXSID40151606 Css NA 0.9579 mg/L 3compartmentss NA 95% Rat Human +DTXSID40151606 Css NA 0.07412 mg/L PBTK NA 50% Rat Human +DTXSID40151606 Css NA 0.5438 mg/L PBTK NA 95% Rat Human +DTXSID40153120 Clint 4.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40153120 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40153120 Vd NA 0.4634 L/kg 1compartment NA NA Human Human +DTXSID40153120 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40153120 TK.Half.Life NA 2.521 hours 1compartment NA NA Human Human +DTXSID40153120 Css NA 0.5792 mg/L 3compartmentss NA 50% Human Human +DTXSID40153120 Css NA 3.832 mg/L 3compartmentss NA 95% Human Human +DTXSID40153120 Css NA 0.3719 mg/L PBTK NA 50% Human Human +DTXSID40153120 Css NA 2.297 mg/L PBTK NA 95% Human Human +DTXSID40153120 Clint 4.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40153120 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40153120 Vd NA 0.4138 L/kg 1compartment NA NA Rat Human +DTXSID40153120 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40153120 TK.Half.Life NA 1.316 hours 1compartment NA NA Rat Human +DTXSID40153120 Css NA 0.02562 mg/L 3compartmentss NA 50% Rat Human +DTXSID40153120 Css NA 0.1865 mg/L 3compartmentss NA 95% Rat Human +DTXSID40153120 Css NA 0.01608 mg/L PBTK NA 50% Rat Human +DTXSID40153120 Css NA 0.1098 mg/L PBTK NA 95% Rat Human +DTXSID40153741 Clint 9.301 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40153741 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40153741 Vd NA 1.478 L/kg 1compartment NA NA Human Human +DTXSID40153741 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40153741 TK.Half.Life NA 3.312 hours 1compartment NA NA Human Human +DTXSID40153741 Css NA 0.1793 mg/L 3compartmentss NA 50% Human Human +DTXSID40153741 Css NA 1.176 mg/L 3compartmentss NA 95% Human Human +DTXSID40153741 Css NA 0.1349 mg/L PBTK NA 50% Human Human +DTXSID40153741 Css NA 0.8125 mg/L PBTK NA 95% Human Human +DTXSID40153741 Clint 9.301 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40153741 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40153741 Vd NA 1.206 L/kg 1compartment NA NA Rat Human +DTXSID40153741 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40153741 TK.Half.Life NA 1.375 hours 1compartment NA NA Rat Human +DTXSID40153741 Css NA 0.0214 mg/L 3compartmentss NA 50% Rat Human +DTXSID40153741 Css NA 0.1038 mg/L 3compartmentss NA 95% Rat Human +DTXSID40153741 Css NA 0.01617 mg/L PBTK NA 50% Rat Human +DTXSID40153741 Css NA 0.06993 mg/L PBTK NA 95% Rat Human +DTXSID40158594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40158594 Fup 0.011 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40158594 Vd NA 1.466 L/kg 1compartment NA NA Human Human +DTXSID40158594 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40158594 TK.Half.Life NA 10.32 hours 1compartment NA NA Human Human +DTXSID40158594 Css NA 1.242 mg/L 3compartmentss NA 50% Human Human +DTXSID40158594 Css NA 11.75 mg/L 3compartmentss NA 95% Human Human +DTXSID40158594 Css NA 0.6456 mg/L PBTK NA 50% Human Human +DTXSID40158594 Css NA 6.108 mg/L PBTK NA 95% Human Human DTXSID40158594 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID40158594 Fup 0.03 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID40158594 Vd NA 1.706 L/kg 1compartment NA NA Rat Rat -DTXSID40158594 Days.Css NA 38 Days PBTK NA NA Rat Rat -DTXSID40158594 TK.Half.Life NA 134.8 hours 1compartment NA NA Rat Rat -DTXSID40158594 Css NA 14.35 mg/L 3compartmentss NA 50% Rat Rat -DTXSID40158594 Css NA 57.37 mg/L 3compartmentss NA 95% Rat Rat -DTXSID40158594 Css NA 7.388 mg/L PBTK NA 50% Rat Rat -DTXSID40158594 Css NA 30.64 mg/L PBTK NA 95% Rat Rat +DTXSID40158594 Vd NA 1.967 L/kg 1compartment NA NA Rat Rat +DTXSID40158594 Days.Css NA 56 Days PBTK NA NA Rat Rat +DTXSID40158594 TK.Half.Life NA 165.8 hours 1compartment NA NA Rat Rat +DTXSID40158594 Css NA 3.818 mg/L 3compartmentss NA 50% Rat Rat +DTXSID40158594 Css NA 13.97 mg/L 3compartmentss NA 95% Rat Rat +DTXSID40158594 Css NA 2.056 mg/L PBTK NA 50% Rat Rat +DTXSID40158594 Css NA 7.523 mg/L PBTK NA 95% Rat Rat +DTXSID40164418 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40164418 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40164418 Vd NA 0.6806 L/kg 1compartment NA NA Human Human +DTXSID40164418 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40164418 TK.Half.Life NA 0.7156 hours 1compartment NA NA Human Human +DTXSID40164418 Css NA 0.04137 mg/L 3compartmentss NA 50% Human Human +DTXSID40164418 Css NA 0.3815 mg/L 3compartmentss NA 95% Human Human +DTXSID40164418 Css NA 0.03167 mg/L PBTK NA 50% Human Human +DTXSID40164418 Css NA 0.2566 mg/L PBTK NA 95% Human Human +DTXSID40164418 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40164418 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40164418 Vd NA 0.6729 L/kg 1compartment NA NA Rat Human +DTXSID40164418 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40164418 TK.Half.Life NA 0.3601 hours 1compartment NA NA Rat Human +DTXSID40164418 Css NA 0.004704 mg/L 3compartmentss NA 50% Rat Human +DTXSID40164418 Css NA 0.03528 mg/L 3compartmentss NA 95% Rat Human +DTXSID40164418 Css NA 0.003607 mg/L PBTK NA 50% Rat Human +DTXSID40164418 Css NA 0.02334 mg/L PBTK NA 95% Rat Human +DTXSID40164615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40164615 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40164615 Vd NA 2.184 L/kg 1compartment NA NA Human Human +DTXSID40164615 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40164615 TK.Half.Life NA 9.908 hours 1compartment NA NA Human Human +DTXSID40164615 Css NA 0.4348 mg/L 3compartmentss NA 50% Human Human +DTXSID40164615 Css NA 2.485 mg/L 3compartmentss NA 95% Human Human +DTXSID40164615 Css NA 0.3322 mg/L PBTK NA 50% Human Human +DTXSID40164615 Css NA 1.752 mg/L PBTK NA 95% Human Human +DTXSID40164615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40164615 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40164615 Vd NA 1.805 L/kg 1compartment NA NA Rat Human +DTXSID40164615 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40164615 TK.Half.Life NA 3.729 hours 1compartment NA NA Rat Human +DTXSID40164615 Css NA 0.05135 mg/L 3compartmentss NA 50% Rat Human +DTXSID40164615 Css NA 0.2085 mg/L 3compartmentss NA 95% Rat Human +DTXSID40164615 Css NA 0.03964 mg/L PBTK NA 50% Rat Human +DTXSID40164615 Css NA 0.1453 mg/L PBTK NA 95% Rat Human +DTXSID40165748 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40165748 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40165748 Vd NA 1.695 L/kg 1compartment NA NA Human Human +DTXSID40165748 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40165748 TK.Half.Life NA 18.2 hours 1compartment NA NA Human Human +DTXSID40165748 Css NA 1.656 mg/L 3compartmentss NA 50% Human Human +DTXSID40165748 Css NA 14.62 mg/L 3compartmentss NA 95% Human Human +DTXSID40165748 Css NA 1.038 mg/L PBTK NA 50% Human Human +DTXSID40165748 Css NA 8.906 mg/L PBTK NA 95% Human Human +DTXSID40165748 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40165748 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40165748 Vd NA 1.256 L/kg 1compartment NA NA Rat Human +DTXSID40165748 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40165748 TK.Half.Life NA 6.57 hours 1compartment NA NA Rat Human +DTXSID40165748 Css NA 0.2165 mg/L 3compartmentss NA 50% Rat Human +DTXSID40165748 Css NA 1.499 mg/L 3compartmentss NA 95% Rat Human +DTXSID40165748 Css NA 0.1324 mg/L PBTK NA 50% Rat Human +DTXSID40165748 Css NA 0.8969 mg/L PBTK NA 95% Rat Human +DTXSID40167045 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40167045 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40167045 Vd NA 1.986 L/kg 1compartment NA NA Human Human +DTXSID40167045 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40167045 TK.Half.Life NA 10.72 hours 1compartment NA NA Human Human +DTXSID40167045 Css NA 0.7058 mg/L 3compartmentss NA 50% Human Human +DTXSID40167045 Css NA 5.358 mg/L 3compartmentss NA 95% Human Human +DTXSID40167045 Css NA 0.4636 mg/L PBTK NA 50% Human Human +DTXSID40167045 Css NA 3.325 mg/L PBTK NA 95% Human Human +DTXSID40167045 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40167045 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40167045 Vd NA 1.488 L/kg 1compartment NA NA Rat Human +DTXSID40167045 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40167045 TK.Half.Life NA 3.517 hours 1compartment NA NA Rat Human +DTXSID40167045 Css NA 0.09074 mg/L 3compartmentss NA 50% Rat Human +DTXSID40167045 Css NA 0.5292 mg/L 3compartmentss NA 95% Rat Human +DTXSID40167045 Css NA 0.05845 mg/L PBTK NA 50% Rat Human +DTXSID40167045 Css NA 0.3258 mg/L PBTK NA 95% Rat Human +DTXSID40167161 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40167161 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40167161 Vd NA 1.8 L/kg 1compartment NA NA Human Human +DTXSID40167161 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID40167161 TK.Half.Life NA 27.86 hours 1compartment NA NA Human Human +DTXSID40167161 Css NA 1.346 mg/L 3compartmentss NA 50% Human Human +DTXSID40167161 Css NA 6.849 mg/L 3compartmentss NA 95% Human Human +DTXSID40167161 Css NA 1.243 mg/L PBTK NA 50% Human Human +DTXSID40167161 Css NA 4.777 mg/L PBTK NA 95% Human Human +DTXSID40167161 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40167161 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40167161 Vd NA 1.813 L/kg 1compartment NA NA Rat Human +DTXSID40167161 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID40167161 TK.Half.Life NA 9.528 hours 1compartment NA NA Rat Human +DTXSID40167161 Css NA 0.08444 mg/L 3compartmentss NA 50% Rat Human +DTXSID40167161 Css NA 0.3783 mg/L 3compartmentss NA 95% Rat Human +DTXSID40167161 Css NA 0.07842 mg/L PBTK NA 50% Rat Human +DTXSID40167161 Css NA 0.2548 mg/L PBTK NA 95% Rat Human +DTXSID40167363 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40167363 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40167363 Vd NA 0.2569 L/kg 1compartment NA NA Human Human +DTXSID40167363 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID40167363 TK.Half.Life NA 19.01 hours 1compartment NA NA Human Human +DTXSID40167363 Css NA 13.72 mg/L 3compartmentss NA 50% Human Human +DTXSID40167363 Css NA 130.8 mg/L 3compartmentss NA 95% Human Human +DTXSID40167363 Css NA 8.002 mg/L PBTK NA 50% Human Human +DTXSID40167363 Css NA 76.1 mg/L PBTK NA 95% Human Human +DTXSID40167363 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40167363 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40167363 Vd NA 0.2294 L/kg 1compartment NA NA Rat Human +DTXSID40167363 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID40167363 TK.Half.Life NA 11.56 hours 1compartment NA NA Rat Human +DTXSID40167363 Css NA 1.822 mg/L 3compartmentss NA 50% Rat Human +DTXSID40167363 Css NA 14.46 mg/L 3compartmentss NA 95% Rat Human +DTXSID40167363 Css NA 1.026 mg/L PBTK NA 50% Rat Human +DTXSID40167363 Css NA 8.086 mg/L PBTK NA 95% Rat Human +DTXSID40170938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40170938 Fup 0.0261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40170938 Vd NA 2.031 L/kg 1compartment NA NA Human Human +DTXSID40170938 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40170938 TK.Half.Life NA 17.53 hours 1compartment NA NA Human Human +DTXSID40170938 Css NA 1.252 mg/L 3compartmentss NA 50% Human Human +DTXSID40170938 Css NA 10.29 mg/L 3compartmentss NA 95% Human Human +DTXSID40170938 Css NA 0.8094 mg/L PBTK NA 50% Human Human +DTXSID40170938 Css NA 6.372 mg/L PBTK NA 95% Human Human +DTXSID40170938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40170938 Fup 0.0261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40170938 Vd NA 1.513 L/kg 1compartment NA NA Rat Human +DTXSID40170938 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40170938 TK.Half.Life NA 5.581 hours 1compartment NA NA Rat Human +DTXSID40170938 Css NA 0.1614 mg/L 3compartmentss NA 50% Rat Human +DTXSID40170938 Css NA 1.045 mg/L 3compartmentss NA 95% Rat Human +DTXSID40170938 Css NA 0.1019 mg/L PBTK NA 50% Rat Human +DTXSID40170938 Css NA 0.6326 mg/L PBTK NA 95% Rat Human +DTXSID40171081 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40171081 Fup 0.48 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40171081 Vd NA 1.576 L/kg 1compartment NA NA Human Human +DTXSID40171081 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40171081 TK.Half.Life NA 3.085 hours 1compartment NA NA Human Human +DTXSID40171081 Css NA 0.149 mg/L 3compartmentss NA 50% Human Human +DTXSID40171081 Css NA 1.017 mg/L 3compartmentss NA 95% Human Human +DTXSID40171081 Css NA 0.1233 mg/L PBTK NA 50% Human Human +DTXSID40171081 Css NA 0.7145 mg/L PBTK NA 95% Human Human +DTXSID40171081 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40171081 Fup 0.48 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40171081 Vd NA 1.319 L/kg 1compartment NA NA Rat Human +DTXSID40171081 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40171081 TK.Half.Life NA 1.277 hours 1compartment NA NA Rat Human +DTXSID40171081 Css NA 0.01703 mg/L 3compartmentss NA 50% Rat Human +DTXSID40171081 Css NA 0.09422 mg/L 3compartmentss NA 95% Rat Human +DTXSID40171081 Css NA 0.01431 mg/L PBTK NA 50% Rat Human +DTXSID40171081 Css NA 0.06349 mg/L PBTK NA 95% Rat Human +DTXSID40171389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40171389 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40171389 Vd NA 1.957 L/kg 1compartment NA NA Human Human +DTXSID40171389 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40171389 TK.Half.Life NA 3.495 hours 1compartment NA NA Human Human +DTXSID40171389 Css NA 0.1148 mg/L 3compartmentss NA 50% Human Human +DTXSID40171389 Css NA 0.7925 mg/L 3compartmentss NA 95% Human Human +DTXSID40171389 Css NA 0.08496 mg/L PBTK NA 50% Human Human +DTXSID40171389 Css NA 0.5516 mg/L PBTK NA 95% Human Human +DTXSID40171389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40171389 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40171389 Vd NA 1.52 L/kg 1compartment NA NA Rat Human +DTXSID40171389 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40171389 TK.Half.Life NA 1.215 hours 1compartment NA NA Rat Human +DTXSID40171389 Css NA 0.009572 mg/L 3compartmentss NA 50% Rat Human +DTXSID40171389 Css NA 0.05426 mg/L 3compartmentss NA 95% Rat Human +DTXSID40171389 Css NA 0.007093 mg/L PBTK NA 50% Rat Human +DTXSID40171389 Css NA 0.0369 mg/L PBTK NA 95% Rat Human +DTXSID40172316 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40172316 Fup 0.0231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40172316 Vd NA 3.035 L/kg 1compartment NA NA Human Human +DTXSID40172316 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID40172316 TK.Half.Life NA 63.19 hours 1compartment NA NA Human Human +DTXSID40172316 Css NA 2.561 mg/L 3compartmentss NA 50% Human Human +DTXSID40172316 Css NA 17.22 mg/L 3compartmentss NA 95% Human Human +DTXSID40172316 Css NA 1.767 mg/L PBTK NA 50% Human Human +DTXSID40172316 Css NA 11.59 mg/L PBTK NA 95% Human Human +DTXSID40172316 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40172316 Fup 0.0231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40172316 Vd NA 2.273 L/kg 1compartment NA NA Rat Human +DTXSID40172316 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID40172316 TK.Half.Life NA 9.659 hours 1compartment NA NA Rat Human +DTXSID40172316 Css NA 0.3306 mg/L 3compartmentss NA 50% Rat Human +DTXSID40172316 Css NA 1.917 mg/L 3compartmentss NA 95% Rat Human +DTXSID40172316 Css NA 0.2246 mg/L PBTK NA 50% Rat Human +DTXSID40172316 Css NA 1.267 mg/L PBTK NA 95% Rat Human +DTXSID40172331 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40172331 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40172331 Vd NA 0.3885 L/kg 1compartment NA NA Human Human +DTXSID40172331 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40172331 TK.Half.Life NA 1.642 hours 1compartment NA NA Human Human +DTXSID40172331 Css NA 0.4225 mg/L 3compartmentss NA 50% Human Human +DTXSID40172331 Css NA 2.997 mg/L 3compartmentss NA 95% Human Human +DTXSID40172331 Css NA 0.275 mg/L PBTK NA 50% Human Human +DTXSID40172331 Css NA 1.813 mg/L PBTK NA 95% Human Human +DTXSID40172331 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40172331 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40172331 Vd NA 0.3899 L/kg 1compartment NA NA Rat Human +DTXSID40172331 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40172331 TK.Half.Life NA 0.983 hours 1compartment NA NA Rat Human +DTXSID40172331 Css NA 0.01916 mg/L 3compartmentss NA 50% Rat Human +DTXSID40172331 Css NA 0.146 mg/L 3compartmentss NA 95% Rat Human +DTXSID40172331 Css NA 0.01225 mg/L PBTK NA 50% Rat Human +DTXSID40172331 Css NA 0.0866 mg/L PBTK NA 95% Rat Human +DTXSID40174158 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40174158 Fup 0.67 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40174158 Vd NA 1.281 L/kg 1compartment NA NA Human Human +DTXSID40174158 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40174158 TK.Half.Life NA 12.43 hours 1compartment NA NA Human Human +DTXSID40174158 Css NA 0.5594 mg/L 3compartmentss NA 50% Human Human +DTXSID40174158 Css NA 4.098 mg/L 3compartmentss NA 95% Human Human +DTXSID40174158 Css NA 0.5006 mg/L PBTK NA 50% Human Human +DTXSID40174158 Css NA 2.662 mg/L PBTK NA 95% Human Human +DTXSID40174158 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40174158 Fup 0.67 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40174158 Vd NA 1.29 L/kg 1compartment NA NA Rat Human +DTXSID40174158 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40174158 TK.Half.Life NA 4.25 hours 1compartment NA NA Rat Human +DTXSID40174158 Css NA 0.00286 mg/L 3compartmentss NA 50% Rat Human +DTXSID40174158 Css NA 0.0219 mg/L 3compartmentss NA 95% Rat Human +DTXSID40174158 Css NA 0.002493 mg/L PBTK NA 50% Rat Human +DTXSID40174158 Css NA 0.01396 mg/L PBTK NA 95% Rat Human +DTXSID40177109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40177109 Fup 0.0216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40177109 Vd NA 3.031 L/kg 1compartment NA NA Human Human +DTXSID40177109 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID40177109 TK.Half.Life NA 64.06 hours 1compartment NA NA Human Human +DTXSID40177109 Css NA 2.58 mg/L 3compartmentss NA 50% Human Human +DTXSID40177109 Css NA 17.1 mg/L 3compartmentss NA 95% Human Human +DTXSID40177109 Css NA 1.765 mg/L PBTK NA 50% Human Human +DTXSID40177109 Css NA 11.46 mg/L PBTK NA 95% Human Human +DTXSID40177109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40177109 Fup 0.0216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40177109 Vd NA 2.271 L/kg 1compartment NA NA Rat Human +DTXSID40177109 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID40177109 TK.Half.Life NA 9.819 hours 1compartment NA NA Rat Human +DTXSID40177109 Css NA 0.3347 mg/L 3compartmentss NA 50% Rat Human +DTXSID40177109 Css NA 1.922 mg/L 3compartmentss NA 95% Rat Human +DTXSID40177109 Css NA 0.2274 mg/L PBTK NA 50% Rat Human +DTXSID40177109 Css NA 1.252 mg/L PBTK NA 95% Rat Human +DTXSID40178252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40178252 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40178252 Vd NA 0.8025 L/kg 1compartment NA NA Human Human +DTXSID40178252 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40178252 TK.Half.Life NA 1.025 hours 1compartment NA NA Human Human +DTXSID40178252 Css NA 0.064 mg/L 3compartmentss NA 50% Human Human +DTXSID40178252 Css NA 0.4819 mg/L 3compartmentss NA 95% Human Human +DTXSID40178252 Css NA 0.04655 mg/L PBTK NA 50% Human Human +DTXSID40178252 Css NA 0.3227 mg/L PBTK NA 95% Human Human +DTXSID40178252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40178252 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40178252 Vd NA 0.7216 L/kg 1compartment NA NA Rat Human +DTXSID40178252 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40178252 TK.Half.Life NA 0.4827 hours 1compartment NA NA Rat Human +DTXSID40178252 Css NA 0.007168 mg/L 3compartmentss NA 50% Rat Human +DTXSID40178252 Css NA 0.04225 mg/L 3compartmentss NA 95% Rat Human +DTXSID40178252 Css NA 0.005262 mg/L PBTK NA 50% Rat Human +DTXSID40178252 Css NA 0.0279 mg/L PBTK NA 95% Rat Human +DTXSID40182293 Clint 6.75 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40182293 Fup 0.0286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40182293 Vd NA 1.233 L/kg 1compartment NA NA Human Human +DTXSID40182293 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID40182293 TK.Half.Life NA 23.48 hours 1compartment NA NA Human Human +DTXSID40182293 Css NA 2.717 mg/L 3compartmentss NA 50% Human Human +DTXSID40182293 Css NA 23.48 mg/L 3compartmentss NA 95% Human Human +DTXSID40182293 Css NA 1.695 mg/L PBTK NA 50% Human Human +DTXSID40182293 Css NA 14.15 mg/L PBTK NA 95% Human Human +DTXSID40182293 Clint 6.75 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40182293 Fup 0.0286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40182293 Vd NA 0.9274 L/kg 1compartment NA NA Rat Human +DTXSID40182293 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID40182293 TK.Half.Life NA 9.648 hours 1compartment NA NA Rat Human +DTXSID40182293 Css NA 0.132 mg/L 3compartmentss NA 50% Rat Human +DTXSID40182293 Css NA 1.199 mg/L 3compartmentss NA 95% Rat Human +DTXSID40182293 Css NA 0.07906 mg/L PBTK NA 50% Rat Human +DTXSID40182293 Css NA 0.6892 mg/L PBTK NA 95% Rat Human +DTXSID40190611 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID40190611 Fup 0.31 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40190611 Vd NA 3.574 L/kg 1compartment NA NA Human Human +DTXSID40190611 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID40190611 TK.Half.Life NA 65.15 hours 1compartment NA NA Human Human +DTXSID40190611 Css NA 1.836 mg/L 3compartmentss NA 50% Human Human +DTXSID40190611 Css NA 10.04 mg/L 3compartmentss NA 95% Human Human +DTXSID40190611 Css NA 1.466 mg/L PBTK NA 50% Human Human +DTXSID40190611 Css NA 7.585 mg/L PBTK NA 95% Human Human +DTXSID40190611 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID40190611 Fup 0.31 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40190611 Vd NA 2.882 L/kg 1compartment NA NA Rat Human +DTXSID40190611 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID40190611 TK.Half.Life NA 10.49 hours 1compartment NA NA Rat Human +DTXSID40190611 Css NA 0.2198 mg/L 3compartmentss NA 50% Rat Human +DTXSID40190611 Css NA 0.8681 mg/L 3compartmentss NA 95% Rat Human +DTXSID40190611 Css NA 0.1777 mg/L PBTK NA 50% Rat Human +DTXSID40190611 Css NA 0.6615 mg/L PBTK NA 95% Rat Human +DTXSID40192791 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40192791 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40192791 Vd NA 2.087 L/kg 1compartment NA NA Human Human +DTXSID40192791 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40192791 TK.Half.Life NA 4.731 hours 1compartment NA NA Human Human +DTXSID40192791 Css NA 0.1594 mg/L 3compartmentss NA 50% Human Human +DTXSID40192791 Css NA 1.124 mg/L 3compartmentss NA 95% Human Human +DTXSID40192791 Css NA 0.148 mg/L PBTK NA 50% Human Human +DTXSID40192791 Css NA 0.8635 mg/L PBTK NA 95% Human Human +DTXSID40192791 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40192791 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40192791 Vd NA 2.093 L/kg 1compartment NA NA Rat Human +DTXSID40192791 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40192791 TK.Half.Life NA 2.743 hours 1compartment NA NA Rat Human +DTXSID40192791 Css NA 0.01871 mg/L 3compartmentss NA 50% Rat Human +DTXSID40192791 Css NA 0.1003 mg/L 3compartmentss NA 95% Rat Human +DTXSID40192791 Css NA 0.01751 mg/L PBTK NA 50% Rat Human +DTXSID40192791 Css NA 0.07395 mg/L PBTK NA 95% Rat Human +DTXSID40193304 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40193304 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40193304 Vd NA 1.65 L/kg 1compartment NA NA Human Human +DTXSID40193304 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40193304 TK.Half.Life NA 3.677 hours 1compartment NA NA Human Human +DTXSID40193304 Css NA 0.193 mg/L 3compartmentss NA 50% Human Human +DTXSID40193304 Css NA 1.434 mg/L 3compartmentss NA 95% Human Human +DTXSID40193304 Css NA 0.1334 mg/L PBTK NA 50% Human Human +DTXSID40193304 Css NA 0.9394 mg/L PBTK NA 95% Human Human +DTXSID40193304 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40193304 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40193304 Vd NA 1.276 L/kg 1compartment NA NA Rat Human +DTXSID40193304 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40193304 TK.Half.Life NA 1.379 hours 1compartment NA NA Rat Human +DTXSID40193304 Css NA 0.02051 mg/L 3compartmentss NA 50% Rat Human +DTXSID40193304 Css NA 0.125 mg/L 3compartmentss NA 95% Rat Human +DTXSID40193304 Css NA 0.01403 mg/L PBTK NA 50% Rat Human +DTXSID40193304 Css NA 0.07963 mg/L PBTK NA 95% Rat Human +DTXSID40193506 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID40193506 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40193506 Vd NA 1.153 L/kg 1compartment NA NA Human Human +DTXSID40193506 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40193506 TK.Half.Life NA 9.455 hours 1compartment NA NA Human Human +DTXSID40193506 Css NA 1.152 mg/L 3compartmentss NA 50% Human Human +DTXSID40193506 Css NA 7.526 mg/L 3compartmentss NA 95% Human Human +DTXSID40193506 Css NA 0.7496 mg/L PBTK NA 50% Human Human +DTXSID40193506 Css NA 4.617 mg/L PBTK NA 95% Human Human +DTXSID40193506 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID40193506 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40193506 Vd NA 0.8951 L/kg 1compartment NA NA Rat Human +DTXSID40193506 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40193506 TK.Half.Life NA 3.954 hours 1compartment NA NA Rat Human +DTXSID40193506 Css NA 0.1377 mg/L 3compartmentss NA 50% Rat Human +DTXSID40193506 Css NA 0.6869 mg/L 3compartmentss NA 95% Rat Human +DTXSID40193506 Css NA 0.08763 mg/L PBTK NA 50% Rat Human +DTXSID40193506 Css NA 0.405 mg/L PBTK NA 95% Rat Human +DTXSID40195580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40195580 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40195580 Vd NA 1.248 L/kg 1compartment NA NA Human Human +DTXSID40195580 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40195580 TK.Half.Life NA 15.56 hours 1compartment NA NA Human Human +DTXSID40195580 Css NA 1.244 mg/L 3compartmentss NA 50% Human Human +DTXSID40195580 Css NA 8.527 mg/L 3compartmentss NA 95% Human Human +DTXSID40195580 Css NA 1.067 mg/L PBTK NA 50% Human Human +DTXSID40195580 Css NA 5.549 mg/L PBTK NA 95% Human Human +DTXSID40195580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40195580 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40195580 Vd NA 1.125 L/kg 1compartment NA NA Rat Human +DTXSID40195580 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40195580 TK.Half.Life NA 4.478 hours 1compartment NA NA Rat Human +DTXSID40195580 Css NA 0.07617 mg/L 3compartmentss NA 50% Rat Human +DTXSID40195580 Css NA 0.5039 mg/L 3compartmentss NA 95% Rat Human +DTXSID40195580 Css NA 0.06525 mg/L PBTK NA 50% Rat Human +DTXSID40195580 Css NA 0.3131 mg/L PBTK NA 95% Rat Human +DTXSID40195984 Clint 29.51 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40195984 Fup 0.0551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40195984 Vd NA 1.779 L/kg 1compartment NA NA Human Human +DTXSID40195984 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40195984 TK.Half.Life NA 6.601 hours 1compartment NA NA Human Human +DTXSID40195984 Css NA 0.4494 mg/L 3compartmentss NA 50% Human Human +DTXSID40195984 Css NA 3.244 mg/L 3compartmentss NA 95% Human Human +DTXSID40195984 Css NA 0.2927 mg/L PBTK NA 50% Human Human +DTXSID40195984 Css NA 2.025 mg/L PBTK NA 95% Human Human +DTXSID40195984 Clint 29.51 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40195984 Fup 0.0551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40195984 Vd NA 1.332 L/kg 1compartment NA NA Rat Human +DTXSID40195984 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40195984 TK.Half.Life NA 2.319 hours 1compartment NA NA Rat Human +DTXSID40195984 Css NA 0.05874 mg/L 3compartmentss NA 50% Rat Human +DTXSID40195984 Css NA 0.3591 mg/L 3compartmentss NA 95% Rat Human +DTXSID40195984 Css NA 0.03754 mg/L PBTK NA 50% Rat Human +DTXSID40195984 Css NA 0.2198 mg/L PBTK NA 95% Rat Human +DTXSID40196133 Clint 4.2 NA uL/min/million hepatocytes NA Yamagata 2017 NA Human Human +DTXSID40196133 Fup 0.051 NA NA Yamagata 2017 NA Human Human +DTXSID40196133 Vd NA 0.93 L/kg 1compartment NA NA Human Human +DTXSID40196133 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40196133 TK.Half.Life NA 15.44 hours 1compartment NA NA Human Human +DTXSID40196133 Css NA 2.098 mg/L 3compartmentss NA 50% Human Human +DTXSID40196133 Css NA 13.35 mg/L 3compartmentss NA 95% Human Human +DTXSID40196133 Css NA 1.467 mg/L PBTK NA 50% Human Human +DTXSID40196133 Css NA 9.342 mg/L PBTK NA 95% Human Human +DTXSID40196133 Clint 4.2 NA uL/min/million hepatocytes NA Yamagata 2017 NA Rat Human +DTXSID40196133 Fup 0.051 NA NA Yamagata 2017 NA Rat Human +DTXSID40196133 Vd NA 0.7138 L/kg 1compartment NA NA Rat Human +DTXSID40196133 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40196133 TK.Half.Life NA 6.665 hours 1compartment NA NA Rat Human +DTXSID40196133 Css NA 0.06746 mg/L 3compartmentss NA 50% Rat Human +DTXSID40196133 Css NA 0.504 mg/L 3compartmentss NA 95% Rat Human +DTXSID40196133 Css NA 0.04778 mg/L PBTK NA 50% Rat Human +DTXSID40196133 Css NA 0.3617 mg/L PBTK NA 95% Rat Human +DTXSID40196931 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40196931 Fup 0.533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40196931 Vd NA 0.6296 L/kg 1compartment NA NA Human Human +DTXSID40196931 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40196931 TK.Half.Life NA 7.664 hours 1compartment NA NA Human Human +DTXSID40196931 Css NA 1.346 mg/L 3compartmentss NA 50% Human Human +DTXSID40196931 Css NA 7.895 mg/L 3compartmentss NA 95% Human Human +DTXSID40196931 Css NA 1.043 mg/L PBTK NA 50% Human Human +DTXSID40196931 Css NA 4.961 mg/L PBTK NA 95% Human Human +DTXSID40196931 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40196931 Fup 0.533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40196931 Vd NA 0.6393 L/kg 1compartment NA NA Rat Human +DTXSID40196931 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40196931 TK.Half.Life NA 2.648 hours 1compartment NA NA Rat Human +DTXSID40196931 Css NA 0.08348 mg/L 3compartmentss NA 50% Rat Human +DTXSID40196931 Css NA 0.4429 mg/L 3compartmentss NA 95% Rat Human +DTXSID40196931 Css NA 0.06404 mg/L PBTK NA 50% Rat Human +DTXSID40196931 Css NA 0.2696 mg/L PBTK NA 95% Rat Human DTXSID4020032 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020032 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020032 Vd NA 0.7095 L/kg 1compartment NA NA Human Human +DTXSID4020032 Vd NA 0.6967 L/kg 1compartment NA NA Human Human DTXSID4020032 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020032 TK.Half.Life NA 4.59 hours 1compartment NA NA Human Human -DTXSID4020032 Css NA 0.8454 mg/L 3compartmentss NA 50% Human Human -DTXSID4020032 Css NA 5.538 mg/L 3compartmentss NA 95% Human Human -DTXSID4020032 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID4020032 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID4020032 TK.Half.Life NA 4.51 hours 1compartment NA NA Human Human +DTXSID4020032 Css NA 0.8146 mg/L 3compartmentss NA 50% Human Human +DTXSID4020032 Css NA 5.609 mg/L 3compartmentss NA 95% Human Human +DTXSID4020032 Css NA 0.6743 mg/L PBTK NA 50% Human Human +DTXSID4020032 Css NA 3.677 mg/L PBTK NA 95% Human Human DTXSID4020032 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020032 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020032 Vd NA 0.7568 L/kg 1compartment NA NA Rat Human +DTXSID4020032 Vd NA 0.7463 L/kg 1compartment NA NA Rat Human DTXSID4020032 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020032 TK.Half.Life NA 1.669 hours 1compartment NA NA Rat Human -DTXSID4020032 Css NA 0.2125 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020032 Css NA 1.315 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020032 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID4020032 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID4020038 Clint NA 3.143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020038 Fup NA 0.0401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020038 Vd NA 0.2339 L/kg 1compartment NA NA Human Human +DTXSID4020032 TK.Half.Life NA 1.645 hours 1compartment NA NA Rat Human +DTXSID4020032 Css NA 0.04779 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020032 Css NA 0.2905 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020032 Css NA 0.03996 mg/L PBTK NA 50% Rat Human +DTXSID4020032 Css NA 0.1803 mg/L PBTK NA 95% Rat Human +DTXSID4020038 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020038 Fup 0.0824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020038 Vd NA 0.2968 L/kg 1compartment NA NA Human Human DTXSID4020038 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020038 TK.Half.Life NA 6.239 hours 1compartment NA NA Human Human -DTXSID4020038 Css NA 4.866 mg/L 3compartmentss NA 50% Human Human -DTXSID4020038 Css NA 35.23 mg/L 3compartmentss NA 95% Human Human -DTXSID4020038 Css NA 2.902 mg/L PBTK NA 50% Human Human -DTXSID4020038 Css NA 20.53 mg/L PBTK NA 95% Human Human -DTXSID4020038 Clint NA 3.143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020038 Fup NA 0.0401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020038 Vd NA 0.2286 L/kg 1compartment NA NA Rat Human +DTXSID4020038 TK.Half.Life NA 0.8852 hours 1compartment NA NA Human Human +DTXSID4020038 Css NA 0.3552 mg/L 3compartmentss NA 50% Human Human +DTXSID4020038 Css NA 2.909 mg/L 3compartmentss NA 95% Human Human +DTXSID4020038 Css NA 0.2193 mg/L PBTK NA 50% Human Human +DTXSID4020038 Css NA 1.73 mg/L PBTK NA 95% Human Human +DTXSID4020038 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020038 Fup 0.0824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020038 Vd NA 0.2904 L/kg 1compartment NA NA Rat Human DTXSID4020038 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020038 TK.Half.Life NA 3.614 hours 1compartment NA NA Rat Human -DTXSID4020038 Css NA 2.404 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020038 Css NA 13.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020038 Css NA 1.342 mg/L PBTK NA 50% Rat Human -DTXSID4020038 Css NA 7.558 mg/L PBTK NA 95% Rat Human -DTXSID4020086 Clint NA 81.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020086 Fup NA 0.168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020086 Vd NA 2.279 L/kg 1compartment NA NA Human Human -DTXSID4020086 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020086 TK.Half.Life NA 2.925 hours 1compartment NA NA Human Human -DTXSID4020086 Css NA 0.06302 mg/L 3compartmentss NA 50% Human Human -DTXSID4020086 Css NA 0.4203 mg/L 3compartmentss NA 95% Human Human -DTXSID4020086 Css NA 0.04488 mg/L PBTK NA 50% Human Human -DTXSID4020086 Css NA 0.2873 mg/L PBTK NA 95% Human Human -DTXSID4020086 Clint NA 81.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020086 Fup NA 0.168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020086 Vd NA 1.737 L/kg 1compartment NA NA Rat Human -DTXSID4020086 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020086 TK.Half.Life NA 0.9298 hours 1compartment NA NA Rat Human -DTXSID4020086 Css NA 0.03502 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020086 Css NA 0.1932 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020086 Css NA 0.02399 mg/L PBTK NA 50% Rat Human -DTXSID4020086 Css NA 0.1286 mg/L PBTK NA 95% Rat Human -DTXSID4020088 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020088 Fup NA 0.3294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020088 Vd NA 0.7222 L/kg 1compartment NA NA Human Human +DTXSID4020038 TK.Half.Life NA 0.5243 hours 1compartment NA NA Rat Human +DTXSID4020038 Css NA 0.04692 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020038 Css NA 0.2863 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020038 Css NA 0.02816 mg/L PBTK NA 50% Rat Human +DTXSID4020038 Css NA 0.1649 mg/L PBTK NA 95% Rat Human +DTXSID4020088 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020088 Fup 0.506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020088 Vd NA 0.9253 L/kg 1compartment NA NA Human Human DTXSID4020088 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4020088 TK.Half.Life NA 14.54 hours 1compartment NA NA Human Human -DTXSID4020088 Css NA 2.232 mg/L 3compartmentss NA 50% Human Human -DTXSID4020088 Css NA 8.982 mg/L 3compartmentss NA 95% Human Human -DTXSID4020088 Css NA 1.648 mg/L PBTK NA 50% Human Human -DTXSID4020088 Css NA 5.779 mg/L PBTK NA 95% Human Human -DTXSID4020088 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020088 Fup NA 0.3294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020088 Vd NA 0.6693 L/kg 1compartment NA NA Rat Human +DTXSID4020088 TK.Half.Life NA 12.29 hours 1compartment NA NA Human Human +DTXSID4020088 Css NA 1.373 mg/L 3compartmentss NA 50% Human Human +DTXSID4020088 Css NA 7.537 mg/L 3compartmentss NA 95% Human Human +DTXSID4020088 Css NA 1.113 mg/L PBTK NA 50% Human Human +DTXSID4020088 Css NA 4.913 mg/L PBTK NA 95% Human Human +DTXSID4020088 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020088 Fup 0.506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020088 Vd NA 0.8606 L/kg 1compartment NA NA Rat Human DTXSID4020088 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020088 TK.Half.Life NA 4.51 hours 1compartment NA NA Rat Human -DTXSID4020088 Css NA 0.6146 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020088 Css NA 2.168 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020088 Css NA 0.432 mg/L PBTK NA 50% Rat Human -DTXSID4020088 Css NA 1.289 mg/L PBTK NA 95% Rat Human +DTXSID4020088 TK.Half.Life NA 3.786 hours 1compartment NA NA Rat Human +DTXSID4020088 Css NA 0.08466 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020088 Css NA 0.4201 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020088 Css NA 0.06834 mg/L PBTK NA 50% Rat Human +DTXSID4020088 Css NA 0.2624 mg/L PBTK NA 95% Rat Human DTXSID4020113 Clint 0.496 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID4020113 Fup 0.61 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4020113 Vd NA 3.805 L/kg 1compartment NA NA Human Human DTXSID4020113 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID4020113 TK.Half.Life NA 22 hours 1compartment NA NA Human Human -DTXSID4020113 Css NA 0.3882 mg/L 3compartmentss NA 50% Human Human -DTXSID4020113 Css NA 3.625 mg/L 3compartmentss NA 95% Human Human -DTXSID4020113 Css NA 0.5191 mg/L PBTK NA 50% Human Human -DTXSID4020113 Css NA 2.77 mg/L PBTK NA 95% Human Human +DTXSID4020113 Css NA 0.3768 mg/L 3compartmentss NA 50% Human Human +DTXSID4020113 Css NA 3.55 mg/L 3compartmentss NA 95% Human Human +DTXSID4020113 Css NA 0.4998 mg/L PBTK NA 50% Human Human +DTXSID4020113 Css NA 2.733 mg/L PBTK NA 95% Human Human DTXSID4020113 Clint 0.496 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID4020113 Fup 0.61 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4020113 Vd NA 3.871 L/kg 1compartment NA NA Rat Human DTXSID4020113 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID4020113 TK.Half.Life NA 9.905 hours 1compartment NA NA Rat Human -DTXSID4020113 Css NA 0.1308 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020113 Css NA 1.279 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020113 Css NA 0.1748 mg/L PBTK NA 50% Rat Human -DTXSID4020113 Css NA 0.8885 mg/L PBTK NA 95% Rat Human -DTXSID4020115 Clint NA 122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020115 Fup NA 0.087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020115 Vd NA 2.661 L/kg 1compartment NA NA Human Human -DTXSID4020115 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020115 TK.Half.Life NA 4.498 hours 1compartment NA NA Human Human -DTXSID4020115 Css NA 0.1213 mg/L 3compartmentss NA 50% Human Human -DTXSID4020115 Css NA 0.8282 mg/L 3compartmentss NA 95% Human Human -DTXSID4020115 Css NA 0.08397 mg/L PBTK NA 50% Human Human -DTXSID4020115 Css NA 0.5398 mg/L PBTK NA 95% Human Human -DTXSID4020115 Clint NA 122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020115 Fup NA 0.087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020115 Vd NA 2.002 L/kg 1compartment NA NA Rat Human -DTXSID4020115 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020115 TK.Half.Life NA 1.226 hours 1compartment NA NA Rat Human -DTXSID4020115 Css NA 0.06828 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020115 Css NA 0.3914 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020115 Css NA 0.04487 mg/L PBTK NA 50% Rat Human -DTXSID4020115 Css NA 0.2456 mg/L PBTK NA 95% Rat Human -DTXSID4020117 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020117 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020117 Vd NA 0.7276 L/kg 1compartment NA NA Human Human +DTXSID4020113 Css NA 0.0291 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020113 Css NA 0.2831 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020113 Css NA 0.04053 mg/L PBTK NA 50% Rat Human +DTXSID4020113 Css NA 0.2064 mg/L PBTK NA 95% Rat Human +DTXSID4020117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020117 Fup 0.894 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020117 Vd NA 0.6712 L/kg 1compartment NA NA Human Human DTXSID4020117 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020117 TK.Half.Life NA 4.709 hours 1compartment NA NA Human Human -DTXSID4020117 Css NA 0.8403 mg/L 3compartmentss NA 50% Human Human -DTXSID4020117 Css NA 5.533 mg/L 3compartmentss NA 95% Human Human -DTXSID4020117 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID4020117 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID4020117 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020117 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020117 Vd NA 0.7731 L/kg 1compartment NA NA Rat Human +DTXSID4020117 TK.Half.Life NA 0.5074 hours 1compartment NA NA Human Human +DTXSID4020117 Css NA 0.00943 mg/L 3compartmentss NA 50% Human Human +DTXSID4020117 Css NA 0.1384 mg/L 3compartmentss NA 95% Human Human +DTXSID4020117 Css NA 0.00752 mg/L PBTK NA 50% Human Human +DTXSID4020117 Css NA 0.09697 mg/L PBTK NA 95% Human Human +DTXSID4020117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020117 Fup 0.894 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020117 Vd NA 0.715 L/kg 1compartment NA NA Rat Human DTXSID4020117 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020117 TK.Half.Life NA 1.704 hours 1compartment NA NA Rat Human -DTXSID4020117 Css NA 0.2111 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020117 Css NA 1.313 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020117 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID4020117 Css NA 0.7874 mg/L PBTK NA 95% Rat Human +DTXSID4020117 TK.Half.Life NA 0.2579 hours 1compartment NA NA Rat Human +DTXSID4020117 Css NA 7.266e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020117 Css NA 0.001193 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020117 Css NA 5.696e-05 mg/L PBTK NA 50% Rat Human +DTXSID4020117 Css NA 0.0007915 mg/L PBTK NA 95% Rat Human DTXSID4020119 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020119 Fup 0.32 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020119 Vd NA 0.3218 L/kg 1compartment NA NA Human Human DTXSID4020119 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4020119 TK.Half.Life NA 6.508 hours 1compartment NA NA Human Human -DTXSID4020119 Css NA 2.086 mg/L 3compartmentss NA 50% Human Human -DTXSID4020119 Css NA 6.467 mg/L 3compartmentss NA 95% Human Human -DTXSID4020119 Css NA 1.392 mg/L PBTK NA 50% Human Human -DTXSID4020119 Css NA 4.062 mg/L PBTK NA 95% Human Human +DTXSID4020119 Css NA 1.155 mg/L 3compartmentss NA 50% Human Human +DTXSID4020119 Css NA 3.949 mg/L 3compartmentss NA 95% Human Human +DTXSID4020119 Css NA 0.7748 mg/L PBTK NA 50% Human Human +DTXSID4020119 Css NA 2.487 mg/L PBTK NA 95% Human Human DTXSID4020119 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020119 Fup 0.32 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020119 Vd NA 0.3283 L/kg 1compartment NA NA Rat Human DTXSID4020119 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4020119 TK.Half.Life NA 2.262 hours 1compartment NA NA Rat Human -DTXSID4020119 Css NA 0.6006 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020119 Css NA 1.413 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020119 Css NA 0.3818 mg/L PBTK NA 50% Rat Human -DTXSID4020119 Css NA 0.8258 mg/L PBTK NA 95% Rat Human +DTXSID4020119 Css NA 0.006526 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020119 Css NA 0.02326 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020119 Css NA 0.004145 mg/L PBTK NA 50% Rat Human +DTXSID4020119 Css NA 0.01407 mg/L PBTK NA 95% Rat Human DTXSID4020240 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020240 Fup 0.761 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4020240 Vd NA 0.6545 L/kg 1compartment NA NA Human Human +DTXSID4020240 Vd NA 0.7918 L/kg 1compartment NA NA Human Human DTXSID4020240 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020240 TK.Half.Life NA 5.567 hours 1compartment NA NA Human Human -DTXSID4020240 Css NA 0.939 mg/L 3compartmentss NA 50% Human Human -DTXSID4020240 Css NA 3.028 mg/L 3compartmentss NA 95% Human Human -DTXSID4020240 Css NA 0.7643 mg/L PBTK NA 50% Human Human -DTXSID4020240 Css NA 2.136 mg/L PBTK NA 95% Human Human +DTXSID4020240 TK.Half.Life NA 6.762 hours 1compartment NA NA Human Human +DTXSID4020240 Css NA 0.8772 mg/L 3compartmentss NA 50% Human Human +DTXSID4020240 Css NA 2.91 mg/L 3compartmentss NA 95% Human Human +DTXSID4020240 Css NA 0.7453 mg/L PBTK NA 50% Human Human +DTXSID4020240 Css NA 2.069 mg/L PBTK NA 95% Human Human DTXSID4020240 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020240 Fup 0.761 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4020240 Vd NA 0.6865 L/kg 1compartment NA NA Rat Human +DTXSID4020240 Vd NA 0.8028 L/kg 1compartment NA NA Rat Human DTXSID4020240 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020240 TK.Half.Life NA 1.99 hours 1compartment NA NA Rat Human -DTXSID4020240 Css NA 0.2485 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020240 Css NA 0.6786 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020240 Css NA 0.1964 mg/L PBTK NA 50% Rat Human -DTXSID4020240 Css NA 0.4419 mg/L PBTK NA 95% Rat Human +DTXSID4020240 TK.Half.Life NA 2.328 hours 1compartment NA NA Rat Human +DTXSID4020240 Css NA 0.05355 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020240 Css NA 0.1481 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020240 Css NA 0.0458 mg/L PBTK NA 50% Rat Human +DTXSID4020240 Css NA 0.1025 mg/L PBTK NA 95% Rat Human DTXSID4020242 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4020242 Fup NA 0.0586 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020242 Vd NA 2.59 L/kg 1compartment NA NA Human Human -DTXSID4020242 Days.Css NA 269 Days PBTK NA NA Human Human -DTXSID4020242 TK.Half.Life NA 1058 hours 1compartment NA NA Human Human -DTXSID4020242 Css NA 18.02 mg/L 3compartmentss NA 50% Human Human -DTXSID4020242 Css NA 127.5 mg/L 3compartmentss NA 95% Human Human -DTXSID4020242 Css NA 13.22 mg/L PBTK NA 50% Human Human -DTXSID4020242 Css NA 81.77 mg/L PBTK NA 95% Human Human +DTXSID4020242 Fup 0.0383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020242 Vd NA 2.374 L/kg 1compartment NA NA Human Human +DTXSID4020242 Days.Css NA 284 Days PBTK NA NA Human Human +DTXSID4020242 TK.Half.Life NA 1108 hours 1compartment NA NA Human Human +DTXSID4020242 Css NA 20.32 mg/L 3compartmentss NA 50% Human Human +DTXSID4020242 Css NA 174.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4020242 Css NA 14.77 mg/L PBTK NA 50% Human Human +DTXSID4020242 Css NA 107 mg/L PBTK NA 95% Human Human DTXSID4020242 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4020242 Fup NA 0.0586 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020242 Vd NA 1.943 L/kg 1compartment NA NA Rat Human -DTXSID4020242 Days.Css NA 66 Days PBTK NA NA Rat Human -DTXSID4020242 TK.Half.Life NA 120.2 hours 1compartment NA NA Rat Human -DTXSID4020242 Css NA 7.674 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020242 Css NA 29.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020242 Css NA 5.521 mg/L PBTK NA 50% Rat Human -DTXSID4020242 Css NA 17.72 mg/L PBTK NA 95% Rat Human +DTXSID4020242 Fup 0.0383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020242 Vd NA 1.775 L/kg 1compartment NA NA Rat Human +DTXSID4020242 Days.Css NA 69 Days PBTK NA NA Rat Human +DTXSID4020242 TK.Half.Life NA 145.2 hours 1compartment NA NA Rat Human +DTXSID4020242 Css NA 1.885 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020242 Css NA 9.463 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020242 Css NA 1.38 mg/L PBTK NA 50% Rat Human +DTXSID4020242 Css NA 5.693 mg/L PBTK NA 95% Rat Human DTXSID4020244 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020244 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020244 Vd NA 0.7401 L/kg 1compartment NA NA Human Human +DTXSID4020244 Vd NA 0.6894 L/kg 1compartment NA NA Human Human DTXSID4020244 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020244 TK.Half.Life NA 4.79 hours 1compartment NA NA Human Human -DTXSID4020244 Css NA 0.8374 mg/L 3compartmentss NA 50% Human Human -DTXSID4020244 Css NA 5.531 mg/L 3compartmentss NA 95% Human Human -DTXSID4020244 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID4020244 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID4020244 TK.Half.Life NA 4.46 hours 1compartment NA NA Human Human +DTXSID4020244 Css NA 0.7158 mg/L 3compartmentss NA 50% Human Human +DTXSID4020244 Css NA 5.073 mg/L 3compartmentss NA 95% Human Human +DTXSID4020244 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID4020244 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID4020244 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020244 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020244 Vd NA 0.7835 L/kg 1compartment NA NA Rat Human +DTXSID4020244 Vd NA 0.7414 L/kg 1compartment NA NA Rat Human DTXSID4020244 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020244 TK.Half.Life NA 1.727 hours 1compartment NA NA Rat Human -DTXSID4020244 Css NA 0.2104 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020244 Css NA 1.334 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020244 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID4020244 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID4020246 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020246 Fup NA 0.1858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020246 Vd NA 0.2713 L/kg 1compartment NA NA Human Human -DTXSID4020246 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020246 TK.Half.Life NA 9.445 hours 1compartment NA NA Human Human -DTXSID4020246 Css NA 4.466 mg/L 3compartmentss NA 50% Human Human -DTXSID4020246 Css NA 15.85 mg/L 3compartmentss NA 95% Human Human -DTXSID4020246 Css NA 2.833 mg/L PBTK NA 50% Human Human -DTXSID4020246 Css NA 9.494 mg/L PBTK NA 95% Human Human -DTXSID4020246 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020246 Fup NA 0.1858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020246 Vd NA 0.274 L/kg 1compartment NA NA Rat Human -DTXSID4020246 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020246 TK.Half.Life NA 3.251 hours 1compartment NA NA Rat Human -DTXSID4020246 Css NA 1.25 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020246 Css NA 3.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020246 Css NA 0.7421 mg/L PBTK NA 50% Rat Human -DTXSID4020246 Css NA 2.075 mg/L PBTK NA 95% Rat Human -DTXSID4020248 Clint NA 3.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020248 Fup NA 0.0536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020248 Vd NA 2.316 L/kg 1compartment NA NA Human Human -DTXSID4020248 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID4020248 TK.Half.Life NA 72.74 hours 1compartment NA NA Human Human -DTXSID4020248 Css NA 4.536 mg/L 3compartmentss NA 50% Human Human -DTXSID4020248 Css NA 24.25 mg/L 3compartmentss NA 95% Human Human -DTXSID4020248 Css NA 3.044 mg/L PBTK NA 50% Human Human -DTXSID4020248 Css NA 15.21 mg/L PBTK NA 95% Human Human -DTXSID4020248 Clint NA 3.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020248 Fup NA 0.0536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020248 Vd NA 1.737 L/kg 1compartment NA NA Rat Human -DTXSID4020248 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID4020248 TK.Half.Life NA 18.6 hours 1compartment NA NA Rat Human -DTXSID4020248 Css NA 2.334 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020248 Css NA 9.065 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020248 Css NA 1.478 mg/L PBTK NA 50% Rat Human -DTXSID4020248 Css NA 5.322 mg/L PBTK NA 95% Rat Human +DTXSID4020244 TK.Half.Life NA 1.634 hours 1compartment NA NA Rat Human +DTXSID4020244 Css NA 0.01314 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020244 Css NA 0.1003 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020244 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID4020244 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID4020248 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020248 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020248 Vd NA 1.535 L/kg 1compartment NA NA Human Human +DTXSID4020248 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4020248 TK.Half.Life NA 16.59 hours 1compartment NA NA Human Human +DTXSID4020248 Css NA 1.68 mg/L 3compartmentss NA 50% Human Human +DTXSID4020248 Css NA 15.58 mg/L 3compartmentss NA 95% Human Human +DTXSID4020248 Css NA 1.052 mg/L PBTK NA 50% Human Human +DTXSID4020248 Css NA 9.278 mg/L PBTK NA 95% Human Human +DTXSID4020248 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020248 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020248 Vd NA 1.136 L/kg 1compartment NA NA Rat Human +DTXSID4020248 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4020248 TK.Half.Life NA 6.313 hours 1compartment NA NA Rat Human +DTXSID4020248 Css NA 0.2213 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020248 Css NA 1.559 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020248 Css NA 0.1342 mg/L PBTK NA 50% Rat Human +DTXSID4020248 Css NA 0.9162 mg/L PBTK NA 95% Rat Human DTXSID4020290 Clint 7.51 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4020290 Fup 0.005454 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID4020290 Vd NA 0.1744 L/kg 1compartment NA NA Human Human +DTXSID4020290 Vd NA 0.1749 L/kg 1compartment NA NA Human Human DTXSID4020290 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4020290 TK.Half.Life NA 15.53 hours 1compartment NA NA Human Human -DTXSID4020290 Css NA 17.01 mg/L 3compartmentss NA 50% Human Human -DTXSID4020290 Css NA 145.8 mg/L 3compartmentss NA 95% Human Human -DTXSID4020290 Css NA 9.908 mg/L PBTK NA 50% Human Human -DTXSID4020290 Css NA 84.67 mg/L PBTK NA 95% Human Human +DTXSID4020290 TK.Half.Life NA 15.59 hours 1compartment NA NA Human Human +DTXSID4020290 Css NA 16.31 mg/L 3compartmentss NA 50% Human Human +DTXSID4020290 Css NA 137.9 mg/L 3compartmentss NA 95% Human Human +DTXSID4020290 Css NA 9.549 mg/L PBTK NA 50% Human Human +DTXSID4020290 Css NA 79.66 mg/L PBTK NA 95% Human Human DTXSID4020290 Clint 7.51 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4020290 Fup 0.005454 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID4020290 Vd NA 0.1718 L/kg 1compartment NA NA Rat Human +DTXSID4020290 Vd 0.099 0.1723 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID4020290 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4020290 TK.Half.Life NA 9.923 hours 1compartment NA NA Rat Human -DTXSID4020290 Css NA 9.214 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020290 Css NA 62.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020290 Css NA 5.006 mg/L PBTK NA 50% Rat Human -DTXSID4020290 Css NA 33.77 mg/L PBTK NA 95% Rat Human -DTXSID4020294 Clint NA 4.309 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020294 Fup NA 0.3113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020294 Vd NA 1.001 L/kg 1compartment NA NA Human Human +DTXSID4020290 TK.Half.Life 0.056 9.96 hours 1compartment National Toxicology Program NA Rat Human +DTXSID4020290 Css 0.034 1.706 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID4020290 Css 0.034 12.29 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID4020290 Css 0.034 0.9553 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID4020290 Css 0.034 6.834 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID4020292 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4020292 Fup NA 0.8675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4020292 Vd NA 1.012 L/kg 1compartment NA NA Human Human +DTXSID4020292 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4020292 TK.Half.Life NA 7.698 hours 1compartment NA NA Human Human +DTXSID4020292 Css NA 0.7578 mg/L 3compartmentss NA 50% Human Human +DTXSID4020292 Css NA 4.716 mg/L 3compartmentss NA 95% Human Human +DTXSID4020292 Css NA 0.667 mg/L PBTK NA 50% Human Human +DTXSID4020292 Css NA 3.107 mg/L PBTK NA 95% Human Human +DTXSID4020292 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4020292 Fup NA 0.8675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4020292 Vd NA 0.9931 L/kg 1compartment NA NA Rat Human +DTXSID4020292 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4020292 TK.Half.Life NA 2.536 hours 1compartment NA NA Rat Human +DTXSID4020292 Css NA 0.01419 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020292 Css NA 0.115 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020292 Css NA 0.012 mg/L PBTK NA 50% Rat Human +DTXSID4020292 Css NA 0.07626 mg/L PBTK NA 95% Rat Human +DTXSID4020294 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020294 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020294 Vd NA 0.8057 L/kg 1compartment NA NA Human Human DTXSID4020294 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020294 TK.Half.Life NA 3.248 hours 1compartment NA NA Human Human -DTXSID4020294 Css NA 0.3123 mg/L 3compartmentss NA 50% Human Human -DTXSID4020294 Css NA 1.838 mg/L 3compartmentss NA 95% Human Human -DTXSID4020294 Css NA 0.2328 mg/L PBTK NA 50% Human Human -DTXSID4020294 Css NA 1.211 mg/L PBTK NA 95% Human Human -DTXSID4020294 Clint NA 4.309 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020294 Fup NA 0.3113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020294 Vd NA 0.8632 L/kg 1compartment NA NA Rat Human +DTXSID4020294 TK.Half.Life NA 1.241 hours 1compartment NA NA Human Human +DTXSID4020294 Css NA 0.09488 mg/L 3compartmentss NA 50% Human Human +DTXSID4020294 Css NA 0.6607 mg/L 3compartmentss NA 95% Human Human +DTXSID4020294 Css NA 0.06637 mg/L PBTK NA 50% Human Human +DTXSID4020294 Css NA 0.4354 mg/L PBTK NA 95% Human Human +DTXSID4020294 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020294 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020294 Vd NA 0.6973 L/kg 1compartment NA NA Rat Human DTXSID4020294 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020294 TK.Half.Life NA 1.523 hours 1compartment NA NA Rat Human -DTXSID4020294 Css NA 0.1528 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020294 Css NA 0.6763 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020294 Css NA 0.1093 mg/L PBTK NA 50% Rat Human -DTXSID4020294 Css NA 0.4196 mg/L PBTK NA 95% Rat Human -DTXSID4020296 Clint NA 10.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020296 Fup NA 0.3806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020296 Vd NA 1.352 L/kg 1compartment NA NA Human Human +DTXSID4020294 TK.Half.Life NA 0.5771 hours 1compartment NA NA Rat Human +DTXSID4020294 Css NA 0.01202 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020294 Css NA 0.06451 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020294 Css NA 0.008348 mg/L PBTK NA 50% Rat Human +DTXSID4020294 Css NA 0.0423 mg/L PBTK NA 95% Rat Human +DTXSID4020296 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020296 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020296 Vd NA 1.23 L/kg 1compartment NA NA Human Human DTXSID4020296 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020296 TK.Half.Life NA 2.217 hours 1compartment NA NA Human Human -DTXSID4020296 Css NA 0.1151 mg/L 3compartmentss NA 50% Human Human -DTXSID4020296 Css NA 0.7639 mg/L 3compartmentss NA 95% Human Human -DTXSID4020296 Css NA 0.09019 mg/L PBTK NA 50% Human Human -DTXSID4020296 Css NA 0.54 mg/L PBTK NA 95% Human Human -DTXSID4020296 Clint NA 10.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020296 Fup NA 0.3806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020296 Vd NA 1.132 L/kg 1compartment NA NA Rat Human +DTXSID4020296 TK.Half.Life NA 2.007 hours 1compartment NA NA Human Human +DTXSID4020296 Css NA 0.1045 mg/L 3compartmentss NA 50% Human Human +DTXSID4020296 Css NA 0.7404 mg/L 3compartmentss NA 95% Human Human +DTXSID4020296 Css NA 0.0748 mg/L PBTK NA 50% Human Human +DTXSID4020296 Css NA 0.496 mg/L PBTK NA 95% Human Human +DTXSID4020296 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020296 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020296 Vd NA 0.9949 L/kg 1compartment NA NA Rat Human DTXSID4020296 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020296 TK.Half.Life NA 0.9504 hours 1compartment NA NA Rat Human -DTXSID4020296 Css NA 0.06006 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020296 Css NA 0.3116 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020296 Css NA 0.0458 mg/L PBTK NA 50% Rat Human -DTXSID4020296 Css NA 0.2092 mg/L PBTK NA 95% Rat Human -DTXSID4020321 Clint NA 5.254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020321 Fup NA 0.2005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020321 Vd NA 3.625 L/kg 1compartment NA NA Human Human +DTXSID4020296 TK.Half.Life NA 0.8382 hours 1compartment NA NA Rat Human +DTXSID4020296 Css NA 0.01326 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020296 Css NA 0.07065 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020296 Css NA 0.009395 mg/L PBTK NA 50% Rat Human +DTXSID4020296 Css NA 0.04731 mg/L PBTK NA 95% Rat Human +DTXSID4020321 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020321 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020321 Vd NA 1.453 L/kg 1compartment NA NA Human Human DTXSID4020321 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020321 TK.Half.Life NA 10.68 hours 1compartment NA NA Human Human -DTXSID4020321 Css NA 0.1942 mg/L 3compartmentss NA 50% Human Human -DTXSID4020321 Css NA 1.307 mg/L 3compartmentss NA 95% Human Human -DTXSID4020321 Css NA 0.224 mg/L PBTK NA 50% Human Human -DTXSID4020321 Css NA 1.197 mg/L PBTK NA 95% Human Human -DTXSID4020321 Clint NA 5.254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020321 Fup NA 0.2005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020321 Vd NA 3.64 L/kg 1compartment NA NA Rat Human +DTXSID4020321 TK.Half.Life NA 1.528 hours 1compartment NA NA Human Human +DTXSID4020321 Css NA 0.04456 mg/L 3compartmentss NA 50% Human Human +DTXSID4020321 Css NA 0.377 mg/L 3compartmentss NA 95% Human Human +DTXSID4020321 Css NA 0.03824 mg/L PBTK NA 50% Human Human +DTXSID4020321 Css NA 0.2771 mg/L PBTK NA 95% Human Human +DTXSID4020321 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020321 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020321 Vd NA 1.461 L/kg 1compartment NA NA Rat Human DTXSID4020321 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020321 TK.Half.Life NA 6.25 hours 1compartment NA NA Rat Human -DTXSID4020321 Css NA 0.09588 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020321 Css NA 0.5193 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020321 Css NA 0.1108 mg/L PBTK NA 50% Rat Human -DTXSID4020321 Css NA 0.4429 mg/L PBTK NA 95% Rat Human -DTXSID4020325 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020325 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020325 Vd NA 0.7342 L/kg 1compartment NA NA Human Human -DTXSID4020325 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020325 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human -DTXSID4020325 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human -DTXSID4020325 Css NA 6.515 mg/L 3compartmentss NA 95% Human Human -DTXSID4020325 Css NA 0.8344 mg/L PBTK NA 50% Human Human -DTXSID4020325 Css NA 4.14 mg/L PBTK NA 95% Human Human -DTXSID4020325 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020325 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020325 Vd NA 0.7548 L/kg 1compartment NA NA Rat Human -DTXSID4020325 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020325 TK.Half.Life NA 2.172 hours 1compartment NA NA Rat Human -DTXSID4020325 Css NA 0.2618 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020325 Css NA 1.629 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020325 Css NA 0.208 mg/L PBTK NA 50% Rat Human -DTXSID4020325 Css NA 0.9689 mg/L PBTK NA 95% Rat Human +DTXSID4020321 TK.Half.Life NA 0.8134 hours 1compartment NA NA Rat Human +DTXSID4020321 Css NA 0.005493 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020321 Css NA 0.03571 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020321 Css NA 0.004742 mg/L PBTK NA 50% Rat Human +DTXSID4020321 Css NA 0.0268 mg/L PBTK NA 95% Rat Human DTXSID4020327 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020327 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020327 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID4020327 Vd NA 0.3283 L/kg 1compartment NA NA Human Human DTXSID4020327 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020327 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID4020327 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID4020327 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID4020327 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID4020327 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID4020327 TK.Half.Life NA 6.57 hours 1compartment NA NA Human Human +DTXSID4020327 Css NA 2.056 mg/L 3compartmentss NA 50% Human Human +DTXSID4020327 Css NA 8.591 mg/L 3compartmentss NA 95% Human Human +DTXSID4020327 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID4020327 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID4020327 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020327 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020327 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID4020327 Vd NA 0.3459 L/kg 1compartment NA NA Rat Human DTXSID4020327 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020327 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID4020327 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020327 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020327 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID4020327 Css NA 1.313 mg/L PBTK NA 95% Rat Human +DTXSID4020327 TK.Half.Life NA 2.36 hours 1compartment NA NA Rat Human +DTXSID4020327 Css NA 0.03854 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020327 Css NA 0.2272 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020327 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID4020327 Css NA 0.1369 mg/L PBTK NA 95% Rat Human +DTXSID40203270 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40203270 Fup 0.0847 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40203270 Vd NA 0.4083 L/kg 1compartment NA NA Human Human +DTXSID40203270 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40203270 TK.Half.Life NA 1.185 hours 1compartment NA NA Human Human +DTXSID40203270 Css NA 0.1846 mg/L 3compartmentss NA 50% Human Human +DTXSID40203270 Css NA 1.65 mg/L 3compartmentss NA 95% Human Human +DTXSID40203270 Css NA 0.1141 mg/L PBTK NA 50% Human Human +DTXSID40203270 Css NA 0.988 mg/L PBTK NA 95% Human Human +DTXSID40203270 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40203270 Fup 0.0847 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40203270 Vd NA 0.3619 L/kg 1compartment NA NA Rat Human +DTXSID40203270 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40203270 TK.Half.Life NA 0.6284 hours 1compartment NA NA Rat Human +DTXSID40203270 Css NA 0.001995 mg/L 3compartmentss NA 50% Rat Human +DTXSID40203270 Css NA 0.01566 mg/L 3compartmentss NA 95% Rat Human +DTXSID40203270 Css NA 0.001155 mg/L PBTK NA 50% Rat Human +DTXSID40203270 Css NA 0.008811 mg/L PBTK NA 95% Rat Human DTXSID4020329 Clint 5.452 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4020329 Fup 0.78 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4020329 Vd NA 1.34 L/kg 1compartment NA NA Human Human DTXSID4020329 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4020329 TK.Half.Life NA 1.706 hours 1compartment NA NA Human Human -DTXSID4020329 Css NA 0.07025 mg/L 3compartmentss NA 50% Human Human -DTXSID4020329 Css NA 0.6153 mg/L 3compartmentss NA 95% Human Human -DTXSID4020329 Css NA 0.06266 mg/L PBTK NA 50% Human Human -DTXSID4020329 Css NA 0.4388 mg/L PBTK NA 95% Human Human +DTXSID4020329 Css NA 0.08268 mg/L 3compartmentss NA 50% Human Human +DTXSID4020329 Css NA 0.5918 mg/L 3compartmentss NA 95% Human Human +DTXSID4020329 Css NA 0.07961 mg/L PBTK NA 50% Human Human +DTXSID4020329 Css NA 0.5714 mg/L PBTK NA 95% Human Human DTXSID4020329 Clint 5.452 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID4020329 Fup 0.78 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4020329 Vd NA 1.34 L/kg 1compartment NA NA Rat Human DTXSID4020329 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4020329 TK.Half.Life NA 0.9132 hours 1compartment NA NA Rat Human -DTXSID4020329 Css NA 0.046 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020329 Css NA 0.3536 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020329 Css NA 0.04094 mg/L PBTK NA 50% Rat Human -DTXSID4020329 Css NA 0.2305 mg/L PBTK NA 95% Rat Human +DTXSID4020329 Css NA 0.006368 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020329 Css NA 0.03688 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020329 Css NA 0.006363 mg/L PBTK NA 50% Rat Human +DTXSID4020329 Css NA 0.03699 mg/L PBTK NA 95% Rat Human +DTXSID40203619 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40203619 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40203619 Vd NA 0.311 L/kg 1compartment NA NA Human Human +DTXSID40203619 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40203619 TK.Half.Life NA 8.828 hours 1compartment NA NA Human Human +DTXSID40203619 Css NA 2.302 mg/L 3compartmentss NA 50% Human Human +DTXSID40203619 Css NA 9.098 mg/L 3compartmentss NA 95% Human Human +DTXSID40203619 Css NA 1.492 mg/L PBTK NA 50% Human Human +DTXSID40203619 Css NA 5.53 mg/L PBTK NA 95% Human Human +DTXSID40203619 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40203619 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40203619 Vd NA 0.3117 L/kg 1compartment NA NA Rat Human +DTXSID40203619 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40203619 TK.Half.Life NA 3.014 hours 1compartment NA NA Rat Human +DTXSID40203619 Css NA 0.0156 mg/L 3compartmentss NA 50% Rat Human +DTXSID40203619 Css NA 0.0777 mg/L 3compartmentss NA 95% Rat Human +DTXSID40203619 Css NA 0.009562 mg/L PBTK NA 50% Rat Human +DTXSID40203619 Css NA 0.04545 mg/L PBTK NA 95% Rat Human DTXSID4020371 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020371 Fup 0.295 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020371 Vd NA 0.6604 L/kg 1compartment NA NA Human Human DTXSID4020371 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID4020371 TK.Half.Life NA 14.78 hours 1compartment NA NA Human Human -DTXSID4020371 Css NA 1.397 mg/L 3compartmentss NA 50% Human Human -DTXSID4020371 Css NA 5.805 mg/L 3compartmentss NA 95% Human Human -DTXSID4020371 Css NA 1.451 mg/L PBTK NA 50% Human Human -DTXSID4020371 Css NA 4.625 mg/L PBTK NA 95% Human Human +DTXSID4020371 Css NA 1.539 mg/L 3compartmentss NA 50% Human Human +DTXSID4020371 Css NA 4.974 mg/L 3compartmentss NA 95% Human Human +DTXSID4020371 Css NA 1.601 mg/L PBTK NA 50% Human Human +DTXSID4020371 Css NA 5.173 mg/L PBTK NA 95% Human Human DTXSID4020371 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020371 Fup 0.295 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020371 Vd NA 0.6149 L/kg 1compartment NA NA Rat Human DTXSID4020371 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020371 TK.Half.Life NA 4.618 hours 1compartment NA NA Rat Human -DTXSID4020371 Css NA 0.4332 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020371 Css NA 1.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020371 Css NA 0.4462 mg/L PBTK NA 50% Rat Human -DTXSID4020371 Css NA 1.112 mg/L PBTK NA 95% Rat Human +DTXSID4020371 TK.Half.Life NA 2.203 hours 1compartment NA NA Rat Human +DTXSID4020371 Css NA 0.04807 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020371 Css NA 0.1296 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020371 Css NA 0.05178 mg/L PBTK NA 50% Rat Human +DTXSID4020371 Css NA 0.1396 mg/L PBTK NA 95% Rat Human DTXSID4020373 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4020373 Fup 0.03115 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4020373 Vd NA 3.825 L/kg 1compartment NA NA Human Human -DTXSID4020373 Days.Css NA 8526 Days PBTK NA NA Human Human +DTXSID4020373 Days.Css NA 3276 Days PBTK NA NA Human Human DTXSID4020373 TK.Half.Life NA 181500 hours 1compartment NA NA Human Human -DTXSID4020373 Css NA 4890 mg/L 3compartmentss NA 50% Human Human -DTXSID4020373 Css NA 11190 mg/L 3compartmentss NA 95% Human Human -DTXSID4020373 Css NA 3620 mg/L PBTK NA 50% Human Human -DTXSID4020373 Css NA 7856 mg/L PBTK NA 95% Human Human +DTXSID4020373 Css NA 4794 mg/L 3compartmentss NA 50% Human Human +DTXSID4020373 Css NA 10790 mg/L 3compartmentss NA 95% Human Human +DTXSID4020373 Css NA 3545 mg/L PBTK NA 50% Human Human +DTXSID4020373 Css NA 7587 mg/L PBTK NA 95% Human Human DTXSID4020373 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4020373 Fup 0.03115 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4020373 Vd NA 2.888 L/kg 1compartment NA NA Rat Human -DTXSID4020373 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID4020373 Days.Css NA 8526 Days PBTK NA NA Rat Human DTXSID4020373 TK.Half.Life NA 11280 hours 1compartment NA NA Rat Human -DTXSID4020373 Css NA 1372 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020373 Css NA 1993 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020373 Css NA 974.5 mg/L PBTK NA 50% Rat Human -DTXSID4020373 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID4020373 Css NA 308.3 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020373 Css NA 451.6 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020373 Css NA 227 mg/L PBTK NA 50% Rat Human +DTXSID4020373 Css NA 311.1 mg/L PBTK NA 95% Rat Human DTXSID4020375 Clint 12.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020375 Fup 3.6e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020375 Vd NA 10.85 L/kg 1compartment NA NA Human Human -DTXSID4020375 Days.Css NA 182 Days PBTK NA NA Human Human +DTXSID4020375 Days.Css NA 180 Days PBTK NA NA Human Human DTXSID4020375 TK.Half.Life NA 756.5 hours 1compartment NA NA Human Human -DTXSID4020375 Css NA 3.927 mg/L 3compartmentss NA 50% Human Human -DTXSID4020375 Css NA 21.4 mg/L 3compartmentss NA 95% Human Human -DTXSID4020375 Css NA 5.237 mg/L PBTK NA 50% Human Human -DTXSID4020375 Css NA 28.2 mg/L PBTK NA 95% Human Human +DTXSID4020375 Css NA 3.835 mg/L 3compartmentss NA 50% Human Human +DTXSID4020375 Css NA 22.22 mg/L 3compartmentss NA 95% Human Human +DTXSID4020375 Css NA 5.057 mg/L PBTK NA 50% Human Human +DTXSID4020375 Css NA 29.16 mg/L PBTK NA 95% Human Human DTXSID4020375 Clint 12.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020375 Fup 3.6e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020375 Vd NA 8.575 L/kg 1compartment NA NA Rat Human DTXSID4020375 Days.Css NA 105 Days PBTK NA NA Rat Human DTXSID4020375 TK.Half.Life NA 418.3 hours 1compartment NA NA Rat Human -DTXSID4020375 Css NA 2.14 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020375 Css NA 9.016 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020375 Css NA 2.846 mg/L PBTK NA 50% Rat Human -DTXSID4020375 Css NA 13.37 mg/L PBTK NA 95% Rat Human -DTXSID4020379 Clint NA 8.954 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020379 Fup NA 0.0947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020379 Vd NA 2.176 L/kg 1compartment NA NA Human Human -DTXSID4020379 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4020379 TK.Half.Life NA 16.7 hours 1compartment NA NA Human Human -DTXSID4020379 Css NA 1.01 mg/L 3compartmentss NA 50% Human Human -DTXSID4020379 Css NA 6.25 mg/L 3compartmentss NA 95% Human Human -DTXSID4020379 Css NA 0.6863 mg/L PBTK NA 50% Human Human -DTXSID4020379 Css NA 4.034 mg/L PBTK NA 95% Human Human -DTXSID4020379 Clint NA 8.954 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020379 Fup NA 0.0947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020379 Vd NA 1.643 L/kg 1compartment NA NA Rat Human +DTXSID4020375 Css NA 0.4802 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020375 Css NA 2.333 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020375 Css NA 0.661 mg/L PBTK NA 50% Rat Human +DTXSID4020375 Css NA 3.397 mg/L PBTK NA 95% Rat Human +DTXSID4020379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020379 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020379 Vd NA 2.473 L/kg 1compartment NA NA Human Human +DTXSID4020379 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4020379 TK.Half.Life NA 7.856 hours 1compartment NA NA Human Human +DTXSID4020379 Css NA 0.3106 mg/L 3compartmentss NA 50% Human Human +DTXSID4020379 Css NA 2.12 mg/L 3compartmentss NA 95% Human Human +DTXSID4020379 Css NA 0.219 mg/L PBTK NA 50% Human Human +DTXSID4020379 Css NA 1.401 mg/L PBTK NA 95% Human Human +DTXSID4020379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020379 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020379 Vd NA 1.875 L/kg 1compartment NA NA Rat Human DTXSID4020379 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020379 TK.Half.Life NA 4.987 hours 1compartment NA NA Rat Human -DTXSID4020379 Css NA 0.5453 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020379 Css NA 2.486 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020379 Css NA 0.353 mg/L PBTK NA 50% Rat Human -DTXSID4020379 Css NA 1.51 mg/L PBTK NA 95% Rat Human -DTXSID4020400 Clint NA 4.396 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020400 Fup NA 0.2713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020400 Vd NA 1.655 L/kg 1compartment NA NA Human Human +DTXSID4020379 TK.Half.Life NA 2.159 hours 1compartment NA NA Rat Human +DTXSID4020379 Css NA 0.03943 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020379 Css NA 0.2062 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020379 Css NA 0.02769 mg/L PBTK NA 50% Rat Human +DTXSID4020379 Css NA 0.1376 mg/L PBTK NA 95% Rat Human +DTXSID4020400 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020400 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020400 Vd NA 0.8365 L/kg 1compartment NA NA Human Human DTXSID4020400 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020400 TK.Half.Life NA 7.033 hours 1compartment NA NA Human Human -DTXSID4020400 Css NA 0.4245 mg/L 3compartmentss NA 50% Human Human -DTXSID4020400 Css NA 2.354 mg/L 3compartmentss NA 95% Human Human -DTXSID4020400 Css NA 0.3191 mg/L PBTK NA 50% Human Human -DTXSID4020400 Css NA 1.603 mg/L PBTK NA 95% Human Human -DTXSID4020400 Clint NA 4.396 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020400 Fup NA 0.2713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020400 Vd NA 1.315 L/kg 1compartment NA NA Rat Human +DTXSID4020400 TK.Half.Life NA 3.134 hours 1compartment NA NA Human Human +DTXSID4020400 Css NA 0.3732 mg/L 3compartmentss NA 50% Human Human +DTXSID4020400 Css NA 2.255 mg/L 3compartmentss NA 95% Human Human +DTXSID4020400 Css NA 0.2576 mg/L PBTK NA 50% Human Human +DTXSID4020400 Css NA 1.465 mg/L PBTK NA 95% Human Human +DTXSID4020400 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020400 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020400 Vd NA 0.707 L/kg 1compartment NA NA Rat Human DTXSID4020400 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020400 TK.Half.Life NA 2.645 hours 1compartment NA NA Rat Human -DTXSID4020400 Css NA 0.2114 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020400 Css NA 0.8201 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020400 Css NA 0.1526 mg/L PBTK NA 50% Rat Human -DTXSID4020400 Css NA 0.5327 mg/L PBTK NA 95% Rat Human +DTXSID4020400 TK.Half.Life NA 1.505 hours 1compartment NA NA Rat Human +DTXSID4020400 Css NA 0.04422 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020400 Css NA 0.1921 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020400 Css NA 0.03022 mg/L PBTK NA 50% Rat Human +DTXSID4020400 Css NA 0.1191 mg/L PBTK NA 95% Rat Human DTXSID4020402 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4020402 Fup NA 0.9281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020402 Vd NA 0.9643 L/kg 1compartment NA NA Human Human +DTXSID4020402 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020402 Vd NA 0.6441 L/kg 1compartment NA NA Human Human DTXSID4020402 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020402 TK.Half.Life NA 6.782 hours 1compartment NA NA Human Human -DTXSID4020402 Css NA 0.8411 mg/L 3compartmentss NA 50% Human Human -DTXSID4020402 Css NA 5.408 mg/L 3compartmentss NA 95% Human Human -DTXSID4020402 Css NA 0.7392 mg/L PBTK NA 50% Human Human -DTXSID4020402 Css NA 3.606 mg/L PBTK NA 95% Human Human +DTXSID4020402 TK.Half.Life NA 8.832 hours 1compartment NA NA Human Human +DTXSID4020402 Css NA 1.389 mg/L 3compartmentss NA 50% Human Human +DTXSID4020402 Css NA 7.349 mg/L 3compartmentss NA 95% Human Human +DTXSID4020402 Css NA 1.081 mg/L PBTK NA 50% Human Human +DTXSID4020402 Css NA 4.687 mg/L PBTK NA 95% Human Human DTXSID4020402 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4020402 Fup NA 0.9281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020402 Vd NA 0.97 L/kg 1compartment NA NA Rat Human +DTXSID4020402 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020402 Vd NA 0.6452 L/kg 1compartment NA NA Rat Human DTXSID4020402 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020402 TK.Half.Life NA 2.31 hours 1compartment NA NA Rat Human -DTXSID4020402 Css NA 0.216 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020402 Css NA 1.317 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020402 Css NA 0.1846 mg/L PBTK NA 50% Rat Human -DTXSID4020402 Css NA 0.8064 mg/L PBTK NA 95% Rat Human +DTXSID4020402 TK.Half.Life NA 3.003 hours 1compartment NA NA Rat Human +DTXSID4020402 Css NA 0.08856 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020402 Css NA 0.4151 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020402 Css NA 0.06787 mg/L PBTK NA 50% Rat Human +DTXSID4020402 Css NA 0.2552 mg/L PBTK NA 95% Rat Human DTXSID4020406 Clint 2.181 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4020406 Fup 0.013 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID4020406 Vd NA 0.7375 L/kg 1compartment NA NA Human Human -DTXSID4020406 Days.Css NA 14 Days PBTK NA NA Human Human -DTXSID4020406 TK.Half.Life NA 72.46 hours 1compartment NA NA Human Human -DTXSID4020406 Css NA 14.37 mg/L 3compartmentss NA 50% Human Human -DTXSID4020406 Css NA 114.7 mg/L 3compartmentss NA 95% Human Human -DTXSID4020406 Css NA 10.67 mg/L PBTK NA 50% Human Human -DTXSID4020406 Css NA 72.66 mg/L PBTK NA 95% Human Human +DTXSID4020406 Vd NA 1.08 L/kg 1compartment NA NA Human Human +DTXSID4020406 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID4020406 TK.Half.Life NA 105.6 hours 1compartment NA NA Human Human +DTXSID4020406 Css NA 13.25 mg/L 3compartmentss NA 50% Human Human +DTXSID4020406 Css NA 90.72 mg/L 3compartmentss NA 95% Human Human +DTXSID4020406 Css NA 10.33 mg/L PBTK NA 50% Human Human +DTXSID4020406 Css NA 70.76 mg/L PBTK NA 95% Human Human DTXSID4020406 Clint 90 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4020406 Fup 0.15 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID4020406 Vd NA 1.896 L/kg 1compartment NA NA Rat Rat +DTXSID4020406 Vd NA 2.097 L/kg 1compartment NA NA Rat Rat DTXSID4020406 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4020406 TK.Half.Life NA 0.8028 hours 1compartment NA NA Rat Rat -DTXSID4020406 Css NA 0.03474 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4020406 Css NA 0.2151 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4020406 Css NA 0.02256 mg/L PBTK NA 50% Rat Rat -DTXSID4020406 Css NA 0.133 mg/L PBTK NA 95% Rat Rat +DTXSID4020406 TK.Half.Life NA 0.9359 hours 1compartment NA NA Rat Rat +DTXSID4020406 Css NA 0.009436 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4020406 Css NA 0.05355 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4020406 Css NA 0.00763 mg/L PBTK NA 50% Rat Rat +DTXSID4020406 Css NA 0.04327 mg/L PBTK NA 95% Rat Rat DTXSID4020450 Clint 27.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020450 Fup 1.57e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020450 Vd NA 0.6599 L/kg 1compartment NA NA Human Human DTXSID4020450 Days.Css NA 27 Days PBTK NA NA Human Human DTXSID4020450 TK.Half.Life NA 127.6 hours 1compartment NA NA Human Human -DTXSID4020450 Css NA 15.72 mg/L 3compartmentss NA 50% Human Human -DTXSID4020450 Css NA 112 mg/L 3compartmentss NA 95% Human Human -DTXSID4020450 Css NA 9.388 mg/L PBTK NA 50% Human Human -DTXSID4020450 Css NA 66.15 mg/L PBTK NA 95% Human Human +DTXSID4020450 Css NA 15.41 mg/L 3compartmentss NA 50% Human Human +DTXSID4020450 Css NA 113.9 mg/L 3compartmentss NA 95% Human Human +DTXSID4020450 Css NA 9.145 mg/L PBTK NA 50% Human Human +DTXSID4020450 Css NA 67.55 mg/L PBTK NA 95% Human Human DTXSID4020450 Clint 27.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020450 Fup 1.57e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020450 Vd NA 0.4823 L/kg 1compartment NA NA Rat Human DTXSID4020450 Days.Css NA 12 Days PBTK NA NA Rat Human DTXSID4020450 TK.Half.Life NA 65.21 hours 1compartment NA NA Rat Human -DTXSID4020450 Css NA 9.783 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020450 Css NA 49.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020450 Css NA 5.458 mg/L PBTK NA 50% Rat Human -DTXSID4020450 Css NA 27.66 mg/L PBTK NA 95% Rat Human +DTXSID4020450 Css NA 2.204 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020450 Css NA 11.32 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020450 Css NA 1.267 mg/L PBTK NA 50% Rat Human +DTXSID4020450 Css NA 6.492 mg/L PBTK NA 95% Rat Human +DTXSID4020452 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020452 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020452 Vd NA 1.544 L/kg 1compartment NA NA Human Human +DTXSID4020452 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4020452 TK.Half.Life NA 32.25 hours 1compartment NA NA Human Human +DTXSID4020452 Css NA 2.099 mg/L 3compartmentss NA 50% Human Human +DTXSID4020452 Css NA 8.577 mg/L 3compartmentss NA 95% Human Human +DTXSID4020452 Css NA 1.676 mg/L PBTK NA 50% Human Human +DTXSID4020452 Css NA 5.75 mg/L PBTK NA 95% Human Human +DTXSID4020452 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020452 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020452 Vd NA 1.271 L/kg 1compartment NA NA Rat Human +DTXSID4020452 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4020452 TK.Half.Life NA 7.562 hours 1compartment NA NA Rat Human +DTXSID4020452 Css NA 0.1323 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020452 Css NA 0.4618 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020452 Css NA 0.1057 mg/L PBTK NA 50% Rat Human +DTXSID4020452 Css NA 0.2977 mg/L PBTK NA 95% Rat Human DTXSID4020458 Clint 2.6 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID4020458 Fup 0.007932 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4020458 Vd NA 2.803 L/kg 1compartment NA NA Human Human DTXSID4020458 Days.Css NA 115 Days PBTK NA NA Human Human DTXSID4020458 TK.Half.Life NA 487.8 hours 1compartment NA NA Human Human -DTXSID4020458 Css NA 27.29 mg/L 3compartmentss NA 50% Human Human -DTXSID4020458 Css NA 160.7 mg/L 3compartmentss NA 95% Human Human -DTXSID4020458 Css NA 16.46 mg/L PBTK NA 50% Human Human -DTXSID4020458 Css NA 94.94 mg/L PBTK NA 95% Human Human +DTXSID4020458 Css NA 21.92 mg/L 3compartmentss NA 50% Human Human +DTXSID4020458 Css NA 135.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4020458 Css NA 16.08 mg/L PBTK NA 50% Human Human +DTXSID4020458 Css NA 99.12 mg/L PBTK NA 95% Human Human DTXSID4020458 Clint 184 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4020458 Fup 0.0179 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4020458 Vd NA 2.232 L/kg 1compartment NA NA Rat Rat DTXSID4020458 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4020458 TK.Half.Life NA 1.818 hours 1compartment NA NA Rat Rat -DTXSID4020458 Css NA 0.2036 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4020458 Css NA 1.134 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4020458 Css NA 0.1127 mg/L PBTK NA 50% Rat Rat -DTXSID4020458 Css NA 0.6224 mg/L PBTK NA 95% Rat Rat +DTXSID4020458 TK.Half.Life 6 1.818 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID4020458 Css NA 0.03492 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4020458 Css NA 0.1952 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4020458 Css NA 0.0265 mg/L PBTK NA 50% Rat Rat +DTXSID4020458 Css NA 0.1483 mg/L PBTK NA 95% Rat Rat DTXSID4020533 Clint 3.485 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID4020533 Fup 0.9398 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID4020533 Vd NA 0.8556 L/kg 1compartment NA NA Human Human DTXSID4020533 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4020533 TK.Half.Life NA 1.222 hours 1compartment NA NA Human Human -DTXSID4020533 Css NA 0.1392 mg/L 3compartmentss NA 50% Human Human -DTXSID4020533 Css NA 0.9715 mg/L 3compartmentss NA 95% Human Human -DTXSID4020533 Css NA 0.1158 mg/L PBTK NA 50% Human Human -DTXSID4020533 Css NA 0.6783 mg/L PBTK NA 95% Human Human +DTXSID4020533 Css NA 0.1126 mg/L 3compartmentss NA 50% Human Human +DTXSID4020533 Css NA 0.852 mg/L 3compartmentss NA 95% Human Human +DTXSID4020533 Css NA 0.09472 mg/L PBTK NA 50% Human Human +DTXSID4020533 Css NA 0.6062 mg/L PBTK NA 95% Human Human DTXSID4020533 Clint 18.9 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID4020533 Fup 0.8829 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat -DTXSID4020533 Vd NA 0.8436 L/kg 1compartment NA NA Rat Rat +DTXSID4020533 Vd 2.3 0.8436 L/kg 1compartment Young et al. (1978), Leung et al. (1990) NA Rat Rat DTXSID4020533 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4020533 TK.Half.Life NA 0.3127 hours 1compartment NA NA Rat Rat -DTXSID4020533 Css NA 0.0154 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4020533 Css NA 0.1199 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4020533 Css NA 0.01264 mg/L PBTK NA 50% Rat Rat -DTXSID4020533 Css NA 0.0823 mg/L PBTK NA 95% Rat Rat +DTXSID4020533 TK.Half.Life 6.1 0.3127 hours 1compartment Young et al. (1978), Leung et al. (1990) NA Rat Rat +DTXSID4020533 Css 0.16 0.0007997 mg/L 3compartmentss Young et al. (1978), Leung et al. (1990) 50% Rat Rat +DTXSID4020533 Css 0.16 0.009065 mg/L 3compartmentss Young et al. (1978), Leung et al. (1990) 95% Rat Rat +DTXSID4020533 Css 0.16 0.0006528 mg/L PBTK Young et al. (1978), Leung et al. (1990) 50% Rat Rat +DTXSID4020533 Css 0.16 0.006349 mg/L PBTK Young et al. (1978), Leung et al. (1990) 95% Rat Rat DTXSID4020535 Clint NA 76.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020535 Fup NA 0.0319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020535 Vd NA 2.869 L/kg 1compartment NA NA Human Human +DTXSID4020535 Vd NA 2.965 L/kg 1compartment NA NA Human Human DTXSID4020535 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020535 TK.Half.Life NA 12.31 hours 1compartment NA NA Human Human -DTXSID4020535 Css NA 0.4872 mg/L 3compartmentss NA 50% Human Human -DTXSID4020535 Css NA 3.266 mg/L 3compartmentss NA 95% Human Human -DTXSID4020535 Css NA 0.3314 mg/L PBTK NA 50% Human Human -DTXSID4020535 Css NA 2.142 mg/L PBTK NA 95% Human Human +DTXSID4020535 TK.Half.Life NA 14.56 hours 1compartment NA NA Human Human +DTXSID4020535 Css NA 0.4644 mg/L 3compartmentss NA 50% Human Human +DTXSID4020535 Css NA 3.207 mg/L 3compartmentss NA 95% Human Human +DTXSID4020535 Css NA 0.319 mg/L PBTK NA 50% Human Human +DTXSID4020535 Css NA 2.136 mg/L PBTK NA 95% Human Human DTXSID4020535 Clint NA 76.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020535 Fup NA 0.0319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020535 Vd NA 2.158 L/kg 1compartment NA NA Rat Human +DTXSID4020535 Vd NA 2.228 L/kg 1compartment NA NA Rat Human DTXSID4020535 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020535 TK.Half.Life NA 2.608 hours 1compartment NA NA Rat Human -DTXSID4020535 Css NA 0.2724 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020535 Css NA 1.503 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020535 Css NA 0.1773 mg/L PBTK NA 50% Rat Human -DTXSID4020535 Css NA 0.9144 mg/L PBTK NA 95% Rat Human +DTXSID4020535 TK.Half.Life NA 2.797 hours 1compartment NA NA Rat Human +DTXSID4020535 Css NA 0.01758 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020535 Css NA 0.1333 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020535 Css NA 0.01162 mg/L PBTK NA 50% Rat Human +DTXSID4020535 Css NA 0.08542 mg/L PBTK NA 95% Rat Human DTXSID4020537 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4020537 Fup 0.4131 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID4020537 Vd NA 5.501 L/kg 1compartment NA NA Human Human -DTXSID4020537 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID4020537 TK.Half.Life NA 106 hours 1compartment NA NA Human Human -DTXSID4020537 Css NA 1.041 mg/L 3compartmentss NA 50% Human Human -DTXSID4020537 Css NA 6.011 mg/L 3compartmentss NA 95% Human Human -DTXSID4020537 Css NA 1.613 mg/L PBTK NA 50% Human Human -DTXSID4020537 Css NA 5.676 mg/L PBTK NA 95% Human Human +DTXSID4020537 Vd NA 5.967 L/kg 1compartment NA NA Human Human +DTXSID4020537 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID4020537 TK.Half.Life NA 150 hours 1compartment NA NA Human Human +DTXSID4020537 Css NA 1.31 mg/L 3compartmentss NA 50% Human Human +DTXSID4020537 Css NA 6.516 mg/L 3compartmentss NA 95% Human Human +DTXSID4020537 Css NA 2.029 mg/L PBTK NA 50% Human Human +DTXSID4020537 Css NA 6.493 mg/L PBTK NA 95% Human Human DTXSID4020537 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4020537 Fup 0.4131 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID4020537 Vd NA 5.54 L/kg 1compartment NA NA Rat Human -DTXSID4020537 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID4020537 TK.Half.Life NA 31.19 hours 1compartment NA NA Rat Human -DTXSID4020537 Css NA 0.2636 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020537 Css NA 1.347 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020537 Css NA 0.4168 mg/L PBTK NA 50% Rat Human -DTXSID4020537 Css NA 1.21 mg/L PBTK NA 95% Rat Human +DTXSID4020537 Vd NA 5.899 L/kg 1compartment NA NA Rat Human +DTXSID4020537 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID4020537 TK.Half.Life NA 36.03 hours 1compartment NA NA Rat Human +DTXSID4020537 Css NA 0.07707 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020537 Css NA 0.3547 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020537 Css NA 0.1268 mg/L PBTK NA 50% Rat Human +DTXSID4020537 Css NA 0.3421 mg/L PBTK NA 95% Rat Human DTXSID4020581 Clint 1.3 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID4020581 Fup 0.5 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID4020581 Vd NA 0.9806 L/kg 1compartment NA NA Human Human DTXSID4020581 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4020581 TK.Half.Life NA 4.472 hours 1compartment NA NA Human Human -DTXSID4020581 Css NA 0.4514 mg/L 3compartmentss NA 50% Human Human -DTXSID4020581 Css NA 2.829 mg/L 3compartmentss NA 95% Human Human -DTXSID4020581 Css NA 0.3656 mg/L PBTK NA 50% Human Human -DTXSID4020581 Css NA 1.902 mg/L PBTK NA 95% Human Human +DTXSID4020581 Css NA 0.4435 mg/L 3compartmentss NA 50% Human Human +DTXSID4020581 Css NA 2.682 mg/L 3compartmentss NA 95% Human Human +DTXSID4020581 Css NA 0.3628 mg/L PBTK NA 50% Human Human +DTXSID4020581 Css NA 1.771 mg/L PBTK NA 95% Human Human DTXSID4020581 Clint 1.3 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID4020581 Fup 0.5 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID4020581 Vd NA 0.9914 L/kg 1compartment NA NA Rat Human DTXSID4020581 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4020581 TK.Half.Life NA 1.89 hours 1compartment NA NA Rat Human -DTXSID4020581 Css NA 0.1599 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020581 Css NA 1.11 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020581 Css NA 0.1318 mg/L PBTK NA 50% Rat Human -DTXSID4020581 Css NA 0.6657 mg/L PBTK NA 95% Rat Human -DTXSID4020587 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020587 Fup NA 0.797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020587 Vd NA 1.277 L/kg 1compartment NA NA Human Human -DTXSID4020587 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4020587 TK.Half.Life NA 11.16 hours 1compartment NA NA Human Human -DTXSID4020587 Css NA 0.932 mg/L 3compartmentss NA 50% Human Human -DTXSID4020587 Css NA 5.695 mg/L 3compartmentss NA 95% Human Human -DTXSID4020587 Css NA 0.8436 mg/L PBTK NA 50% Human Human -DTXSID4020587 Css NA 3.821 mg/L PBTK NA 95% Human Human -DTXSID4020587 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020587 Fup NA 0.797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020587 Vd NA 1.178 L/kg 1compartment NA NA Rat Human -DTXSID4020587 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020587 TK.Half.Life NA 3.318 hours 1compartment NA NA Rat Human -DTXSID4020587 Css NA 0.2405 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020587 Css NA 1.523 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020587 Css NA 0.2121 mg/L PBTK NA 50% Rat Human -DTXSID4020587 Css NA 0.94 mg/L PBTK NA 95% Rat Human -DTXSID4020589 Clint NA 12.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020589 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020589 Vd NA 3.583 L/kg 1compartment NA NA Human Human -DTXSID4020589 Days.Css NA 38 Days PBTK NA NA Human Human -DTXSID4020589 TK.Half.Life NA 192.2 hours 1compartment NA NA Human Human -DTXSID4020589 Css NA 6.029 mg/L 3compartmentss NA 50% Human Human -DTXSID4020589 Css NA 34.99 mg/L 3compartmentss NA 95% Human Human -DTXSID4020589 Css NA 4.377 mg/L PBTK NA 50% Human Human -DTXSID4020589 Css NA 24.92 mg/L PBTK NA 95% Human Human -DTXSID4020589 Clint NA 12.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020589 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020589 Vd NA 2.698 L/kg 1compartment NA NA Rat Human -DTXSID4020589 Days.Css NA 21 Days PBTK NA NA Rat Human -DTXSID4020589 TK.Half.Life NA 25.45 hours 1compartment NA NA Rat Human -DTXSID4020589 Css NA 3.412 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020589 Css NA 15.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020589 Css NA 2.359 mg/L PBTK NA 50% Rat Human -DTXSID4020589 Css NA 10.41 mg/L PBTK NA 95% Rat Human -DTXSID4020612 Clint NA 2.892 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020612 Fup NA 0.389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020612 Vd NA 0.8922 L/kg 1compartment NA NA Human Human +DTXSID4020581 Css NA 0.03596 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020581 Css NA 0.2542 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020581 Css NA 0.03056 mg/L PBTK NA 50% Rat Human +DTXSID4020581 Css NA 0.1597 mg/L PBTK NA 95% Rat Human +DTXSID4020589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020589 Fup 0.00846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020589 Vd NA 3.101 L/kg 1compartment NA NA Human Human +DTXSID4020589 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID4020589 TK.Half.Life NA 93.78 hours 1compartment NA NA Human Human +DTXSID4020589 Css NA 3.502 mg/L 3compartmentss NA 50% Human Human +DTXSID4020589 Css NA 21.34 mg/L 3compartmentss NA 95% Human Human +DTXSID4020589 Css NA 2.425 mg/L PBTK NA 50% Human Human +DTXSID4020589 Css NA 14.71 mg/L PBTK NA 95% Human Human +DTXSID4020589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020589 Fup 0.00846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020589 Vd NA 2.322 L/kg 1compartment NA NA Rat Human +DTXSID4020589 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID4020589 TK.Half.Life NA 12.9 hours 1compartment NA NA Rat Human +DTXSID4020589 Css NA 0.4591 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020589 Css NA 2.252 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020589 Css NA 0.3144 mg/L PBTK NA 50% Rat Human +DTXSID4020589 Css NA 1.564 mg/L PBTK NA 95% Rat Human +DTXSID4020612 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020612 Fup 0.353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020612 Vd NA 0.7949 L/kg 1compartment NA NA Human Human DTXSID4020612 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020612 TK.Half.Life NA 3.066 hours 1compartment NA NA Human Human -DTXSID4020612 Css NA 0.3359 mg/L 3compartmentss NA 50% Human Human -DTXSID4020612 Css NA 1.895 mg/L 3compartmentss NA 95% Human Human -DTXSID4020612 Css NA 0.2565 mg/L PBTK NA 50% Human Human -DTXSID4020612 Css NA 1.271 mg/L PBTK NA 95% Human Human -DTXSID4020612 Clint NA 2.892 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020612 Fup NA 0.389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020612 Vd NA 0.8069 L/kg 1compartment NA NA Rat Human +DTXSID4020612 TK.Half.Life NA 0.9472 hours 1compartment NA NA Human Human +DTXSID4020612 Css NA 0.05578 mg/L 3compartmentss NA 50% Human Human +DTXSID4020612 Css NA 0.4231 mg/L 3compartmentss NA 95% Human Human +DTXSID4020612 Css NA 0.04173 mg/L PBTK NA 50% Human Human +DTXSID4020612 Css NA 0.2882 mg/L PBTK NA 95% Human Human +DTXSID4020612 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020612 Fup 0.353 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020612 Vd NA 0.7275 L/kg 1compartment NA NA Rat Human DTXSID4020612 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020612 TK.Half.Life NA 1.491 hours 1compartment NA NA Rat Human -DTXSID4020612 Css NA 0.1551 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020612 Css NA 0.6773 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020612 Css NA 0.1153 mg/L PBTK NA 50% Rat Human -DTXSID4020612 Css NA 0.4169 mg/L PBTK NA 95% Rat Human -DTXSID4020614 Clint NA 120 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020614 Fup NA 0.0493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020614 Vd NA 2.731 L/kg 1compartment NA NA Human Human -DTXSID4020614 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020614 TK.Half.Life NA 6.284 hours 1compartment NA NA Human Human -DTXSID4020614 Css NA 0.2091 mg/L 3compartmentss NA 50% Human Human -DTXSID4020614 Css NA 1.361 mg/L 3compartmentss NA 95% Human Human -DTXSID4020614 Css NA 0.1419 mg/L PBTK NA 50% Human Human -DTXSID4020614 Css NA 0.9065 mg/L PBTK NA 95% Human Human -DTXSID4020614 Clint NA 120 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020614 Fup NA 0.0493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020614 Vd NA 2.047 L/kg 1compartment NA NA Rat Human -DTXSID4020614 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020614 TK.Half.Life NA 1.564 hours 1compartment NA NA Rat Human -DTXSID4020614 Css NA 0.1166 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020614 Css NA 0.6781 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020614 Css NA 0.07549 mg/L PBTK NA 50% Rat Human -DTXSID4020614 Css NA 0.4214 mg/L PBTK NA 95% Rat Human -DTXSID4020618 Clint NA 2.004 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020618 Fup NA 0.2053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020618 Vd NA 2.897 L/kg 1compartment NA NA Human Human -DTXSID4020618 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID4020618 TK.Half.Life NA 101.1 hours 1compartment NA NA Human Human -DTXSID4020618 Css NA 4.077 mg/L 3compartmentss NA 50% Human Human -DTXSID4020618 Css NA 17 mg/L 3compartmentss NA 95% Human Human -DTXSID4020618 Css NA 2.931 mg/L PBTK NA 50% Human Human -DTXSID4020618 Css NA 11.58 mg/L PBTK NA 95% Human Human -DTXSID4020618 Clint NA 2.004 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020618 Fup NA 0.2053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020618 Vd NA 2.189 L/kg 1compartment NA NA Rat Human -DTXSID4020618 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID4020618 TK.Half.Life NA 16.13 hours 1compartment NA NA Rat Human -DTXSID4020618 Css NA 1.945 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020618 Css NA 5.62 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020618 Css NA 1.341 mg/L PBTK NA 50% Rat Human -DTXSID4020618 Css NA 3.58 mg/L PBTK NA 95% Rat Human +DTXSID4020612 TK.Half.Life NA 0.4495 hours 1compartment NA NA Rat Human +DTXSID4020612 Css NA 0.006894 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020612 Css NA 0.04065 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020612 Css NA 0.005145 mg/L PBTK NA 50% Rat Human +DTXSID4020612 Css NA 0.0279 mg/L PBTK NA 95% Rat Human +DTXSID4020614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020614 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020614 Vd NA 2.982 L/kg 1compartment NA NA Human Human +DTXSID4020614 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID4020614 TK.Half.Life NA 62.33 hours 1compartment NA NA Human Human +DTXSID4020614 Css NA 2.617 mg/L 3compartmentss NA 50% Human Human +DTXSID4020614 Css NA 17.94 mg/L 3compartmentss NA 95% Human Human +DTXSID4020614 Css NA 1.788 mg/L PBTK NA 50% Human Human +DTXSID4020614 Css NA 11.75 mg/L PBTK NA 95% Human Human +DTXSID4020614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020614 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020614 Vd NA 2.232 L/kg 1compartment NA NA Rat Human +DTXSID4020614 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4020614 TK.Half.Life NA 10.11 hours 1compartment NA NA Rat Human +DTXSID4020614 Css NA 0.3372 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020614 Css NA 1.986 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020614 Css NA 0.2276 mg/L PBTK NA 50% Rat Human +DTXSID4020614 Css NA 1.312 mg/L PBTK NA 95% Rat Human +DTXSID4020618 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020618 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020618 Vd NA 2.607 L/kg 1compartment NA NA Human Human +DTXSID4020618 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4020618 TK.Half.Life NA 10.89 hours 1compartment NA NA Human Human +DTXSID4020618 Css NA 0.4472 mg/L 3compartmentss NA 50% Human Human +DTXSID4020618 Css NA 2.901 mg/L 3compartmentss NA 95% Human Human +DTXSID4020618 Css NA 0.3114 mg/L PBTK NA 50% Human Human +DTXSID4020618 Css NA 1.938 mg/L PBTK NA 95% Human Human +DTXSID4020618 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020618 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020618 Vd NA 1.968 L/kg 1compartment NA NA Rat Human +DTXSID4020618 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4020618 TK.Half.Life NA 2.712 hours 1compartment NA NA Rat Human +DTXSID4020618 Css NA 0.05782 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020618 Css NA 0.2934 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020618 Css NA 0.03962 mg/L PBTK NA 50% Rat Human +DTXSID4020618 Css NA 0.1928 mg/L PBTK NA 95% Rat Human DTXSID4020664 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020664 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020664 Vd NA 0.8791 L/kg 1compartment NA NA Human Human +DTXSID4020664 Vd NA 1.115 L/kg 1compartment NA NA Human Human DTXSID4020664 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020664 TK.Half.Life NA 5.705 hours 1compartment NA NA Human Human -DTXSID4020664 Css NA 0.8028 mg/L 3compartmentss NA 50% Human Human -DTXSID4020664 Css NA 5.427 mg/L 3compartmentss NA 95% Human Human -DTXSID4020664 Css NA 0.6972 mg/L PBTK NA 50% Human Human -DTXSID4020664 Css NA 3.601 mg/L PBTK NA 95% Human Human +DTXSID4020664 TK.Half.Life NA 7.382 hours 1compartment NA NA Human Human +DTXSID4020664 Css NA 0.6534 mg/L 3compartmentss NA 50% Human Human +DTXSID4020664 Css NA 4.859 mg/L 3compartmentss NA 95% Human Human +DTXSID4020664 Css NA 0.5936 mg/L PBTK NA 50% Human Human +DTXSID4020664 Css NA 3.23 mg/L PBTK NA 95% Human Human DTXSID4020664 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020664 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020664 Vd NA 0.9033 L/kg 1compartment NA NA Rat Human +DTXSID4020664 Vd NA 1.097 L/kg 1compartment NA NA Rat Human DTXSID4020664 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020664 TK.Half.Life NA 1.993 hours 1compartment NA NA Rat Human -DTXSID4020664 Css NA 0.2023 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020664 Css NA 1.248 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020664 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID4020664 Css NA 0.7616 mg/L PBTK NA 95% Rat Human +DTXSID4020664 TK.Half.Life NA 2.431 hours 1compartment NA NA Rat Human +DTXSID4020664 Css NA 0.01187 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020664 Css NA 0.09458 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020664 Css NA 0.01053 mg/L PBTK NA 50% Rat Human +DTXSID4020664 Css NA 0.06606 mg/L PBTK NA 95% Rat Human DTXSID4020666 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020666 Fup NA 0.7508 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020666 Vd NA 0.6681 L/kg 1compartment NA NA Human Human DTXSID4020666 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4020666 TK.Half.Life NA 5.762 hours 1compartment NA NA Human Human -DTXSID4020666 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human -DTXSID4020666 Css NA 6.501 mg/L 3compartmentss NA 95% Human Human -DTXSID4020666 Css NA 0.838 mg/L PBTK NA 50% Human Human -DTXSID4020666 Css NA 4.12 mg/L PBTK NA 95% Human Human +DTXSID4020666 Css NA 0.895 mg/L 3compartmentss NA 50% Human Human +DTXSID4020666 Css NA 5.577 mg/L 3compartmentss NA 95% Human Human +DTXSID4020666 Css NA 0.7204 mg/L PBTK NA 50% Human Human +DTXSID4020666 Css NA 3.563 mg/L PBTK NA 95% Human Human DTXSID4020666 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020666 Fup NA 0.7508 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020666 Vd NA 0.6972 L/kg 1compartment NA NA Rat Human DTXSID4020666 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4020666 TK.Half.Life NA 2.048 hours 1compartment NA NA Rat Human -DTXSID4020666 Css NA 0.2712 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020666 Css NA 1.672 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020666 Css NA 0.2109 mg/L PBTK NA 50% Rat Human -DTXSID4020666 Css NA 0.9876 mg/L PBTK NA 95% Rat Human +DTXSID4020666 Css NA 0.01646 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020666 Css NA 0.1375 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020666 Css NA 0.01284 mg/L PBTK NA 50% Rat Human +DTXSID4020666 Css NA 0.08641 mg/L PBTK NA 95% Rat Human DTXSID4020668 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020668 Fup NA 0.9312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020668 Vd NA 0.7662 L/kg 1compartment NA NA Human Human +DTXSID4020668 Vd NA 0.8014 L/kg 1compartment NA NA Human Human DTXSID4020668 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020668 TK.Half.Life NA 5.328 hours 1compartment NA NA Human Human -DTXSID4020668 Css NA 0.8615 mg/L 3compartmentss NA 50% Human Human -DTXSID4020668 Css NA 3.132 mg/L 3compartmentss NA 95% Human Human -DTXSID4020668 Css NA 0.7208 mg/L PBTK NA 50% Human Human -DTXSID4020668 Css NA 2.209 mg/L PBTK NA 95% Human Human +DTXSID4020668 TK.Half.Life NA 5.576 hours 1compartment NA NA Human Human +DTXSID4020668 Css NA 0.7293 mg/L 3compartmentss NA 50% Human Human +DTXSID4020668 Css NA 2.724 mg/L 3compartmentss NA 95% Human Human +DTXSID4020668 Css NA 0.6167 mg/L PBTK NA 50% Human Human +DTXSID4020668 Css NA 1.908 mg/L PBTK NA 95% Human Human DTXSID4020668 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020668 Fup NA 0.9312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020668 Vd NA 0.7993 L/kg 1compartment NA NA Rat Human +DTXSID4020668 Vd NA 0.8295 L/kg 1compartment NA NA Rat Human DTXSID4020668 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020668 TK.Half.Life NA 1.893 hours 1compartment NA NA Rat Human -DTXSID4020668 Css NA 0.2236 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020668 Css NA 0.7704 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020668 Css NA 0.1826 mg/L PBTK NA 50% Rat Human -DTXSID4020668 Css NA 0.4945 mg/L PBTK NA 95% Rat Human -DTXSID4020745 Clint NA 6.432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020745 Fup NA 0.1993 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020745 Vd NA 1.099 L/kg 1compartment NA NA Human Human +DTXSID4020668 TK.Half.Life NA 1.965 hours 1compartment NA NA Rat Human +DTXSID4020668 Css NA 0.0132 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020668 Css NA 0.06913 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020668 Css NA 0.0107 mg/L PBTK NA 50% Rat Human +DTXSID4020668 Css NA 0.05073 mg/L PBTK NA 95% Rat Human +DTXSID4020745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020745 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020745 Vd NA 2.223 L/kg 1compartment NA NA Human Human DTXSID4020745 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020745 TK.Half.Life NA 3.763 hours 1compartment NA NA Human Human -DTXSID4020745 Css NA 0.331 mg/L 3compartmentss NA 50% Human Human -DTXSID4020745 Css NA 2.013 mg/L 3compartmentss NA 95% Human Human -DTXSID4020745 Css NA 0.2449 mg/L PBTK NA 50% Human Human -DTXSID4020745 Css NA 1.346 mg/L PBTK NA 95% Human Human -DTXSID4020745 Clint NA 6.432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020745 Fup NA 0.1993 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020745 Vd NA 1.051 L/kg 1compartment NA NA Rat Human +DTXSID4020745 TK.Half.Life NA 2.282 hours 1compartment NA NA Human Human +DTXSID4020745 Css NA 0.04291 mg/L 3compartmentss NA 50% Human Human +DTXSID4020745 Css NA 0.3782 mg/L 3compartmentss NA 95% Human Human +DTXSID4020745 Css NA 0.03994 mg/L PBTK NA 50% Human Human +DTXSID4020745 Css NA 0.2895 mg/L PBTK NA 95% Human Human +DTXSID4020745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020745 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020745 Vd NA 2.095 L/kg 1compartment NA NA Rat Human DTXSID4020745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020745 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human -DTXSID4020745 Css NA 0.1697 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020745 Css NA 0.7405 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020745 Css NA 0.1193 mg/L PBTK NA 50% Rat Human -DTXSID4020745 Css NA 0.4648 mg/L PBTK NA 95% Rat Human -DTXSID4020749 Clint NA 198.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020749 Fup NA 0.1043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020749 Vd NA 1.708 L/kg 1compartment NA NA Human Human +DTXSID4020745 TK.Half.Life NA 1.088 hours 1compartment NA NA Rat Human +DTXSID4020745 Css NA 0.005322 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020745 Css NA 0.03521 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020745 Css NA 0.004982 mg/L PBTK NA 50% Rat Human +DTXSID4020745 Css NA 0.02736 mg/L PBTK NA 95% Rat Human +DTXSID4020749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020749 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020749 Vd NA 2.281 L/kg 1compartment NA NA Human Human DTXSID4020749 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020749 TK.Half.Life NA 1.818 hours 1compartment NA NA Human Human -DTXSID4020749 Css NA 0.03668 mg/L 3compartmentss NA 50% Human Human -DTXSID4020749 Css NA 0.2886 mg/L 3compartmentss NA 95% Human Human -DTXSID4020749 Css NA 0.02451 mg/L PBTK NA 50% Human Human -DTXSID4020749 Css NA 0.1852 mg/L PBTK NA 95% Human Human -DTXSID4020749 Clint NA 198.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020749 Fup NA 0.1043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020749 Vd NA 1.297 L/kg 1compartment NA NA Rat Human +DTXSID4020749 TK.Half.Life NA 8.598 hours 1compartment NA NA Human Human +DTXSID4020749 Css NA 0.4158 mg/L 3compartmentss NA 50% Human Human +DTXSID4020749 Css NA 2.94 mg/L 3compartmentss NA 95% Human Human +DTXSID4020749 Css NA 0.2829 mg/L PBTK NA 50% Human Human +DTXSID4020749 Css NA 1.925 mg/L PBTK NA 95% Human Human +DTXSID4020749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020749 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020749 Vd NA 1.72 L/kg 1compartment NA NA Rat Human DTXSID4020749 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020749 TK.Half.Life NA 0.6228 hours 1compartment NA NA Rat Human -DTXSID4020749 Css NA 0.0206 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020749 Css NA 0.131 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020749 Css NA 0.013 mg/L PBTK NA 50% Rat Human -DTXSID4020749 Css NA 0.08009 mg/L PBTK NA 95% Rat Human +DTXSID4020749 TK.Half.Life NA 2.525 hours 1compartment NA NA Rat Human +DTXSID4020749 Css NA 0.0536 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020749 Css NA 0.2866 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020749 Css NA 0.03608 mg/L PBTK NA 50% Rat Human +DTXSID4020749 Css NA 0.1843 mg/L PBTK NA 95% Rat Human DTXSID4020791 Clint 368 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020791 Fup 0.145 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020791 Vd NA 1.292 L/kg 1compartment NA NA Human Human DTXSID4020791 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4020791 TK.Half.Life NA 1.154 hours 1compartment NA NA Human Human -DTXSID4020791 Css NA 0.01034 mg/L 3compartmentss NA 50% Human Human -DTXSID4020791 Css NA 0.07897 mg/L 3compartmentss NA 95% Human Human -DTXSID4020791 Css NA 0.007074 mg/L PBTK NA 50% Human Human -DTXSID4020791 Css NA 0.05153 mg/L PBTK NA 95% Human Human +DTXSID4020791 Css NA 0.002006 mg/L 3compartmentss NA 50% Human Human +DTXSID4020791 Css NA 0.0365 mg/L 3compartmentss NA 95% Human Human +DTXSID4020791 Css NA 0.001378 mg/L PBTK NA 50% Human Human +DTXSID4020791 Css NA 0.02446 mg/L PBTK NA 95% Human Human DTXSID4020791 Clint 368 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020791 Fup 0.145 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020791 Vd NA 1.015 L/kg 1compartment NA NA Rat Human DTXSID4020791 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4020791 TK.Half.Life NA 0.407 hours 1compartment NA NA Rat Human -DTXSID4020791 Css NA 0.005903 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020791 Css NA 0.03465 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020791 Css NA 0.003872 mg/L PBTK NA 50% Rat Human -DTXSID4020791 Css NA 0.02214 mg/L PBTK NA 95% Rat Human +DTXSID4020791 Css NA 1.557e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020791 Css NA 0.0003229 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020791 Css NA 1.024e-05 mg/L PBTK NA 50% Rat Human +DTXSID4020791 Css NA 0.0002023 mg/L PBTK NA 95% Rat Human DTXSID4020820 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4020820 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020820 Vd NA 0.8765 L/kg 1compartment NA NA Human Human +DTXSID4020820 Fup 0.554 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020820 Vd NA 0.6157 L/kg 1compartment NA NA Human Human DTXSID4020820 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020820 TK.Half.Life NA 5.691 hours 1compartment NA NA Human Human -DTXSID4020820 Css NA 0.8007 mg/L 3compartmentss NA 50% Human Human -DTXSID4020820 Css NA 5.403 mg/L 3compartmentss NA 95% Human Human -DTXSID4020820 Css NA 0.6962 mg/L PBTK NA 50% Human Human -DTXSID4020820 Css NA 3.602 mg/L PBTK NA 95% Human Human +DTXSID4020820 TK.Half.Life NA 7.203 hours 1compartment NA NA Human Human +DTXSID4020820 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human +DTXSID4020820 Css NA 7.687 mg/L 3compartmentss NA 95% Human Human +DTXSID4020820 Css NA 0.8859 mg/L PBTK NA 50% Human Human +DTXSID4020820 Css NA 4.842 mg/L PBTK NA 95% Human Human DTXSID4020820 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4020820 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020820 Vd NA 0.9007 L/kg 1compartment NA NA Rat Human +DTXSID4020820 Fup 0.554 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020820 Vd NA 0.6305 L/kg 1compartment NA NA Rat Human DTXSID4020820 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020820 TK.Half.Life NA 1.988 hours 1compartment NA NA Rat Human -DTXSID4020820 Css NA 0.2024 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020820 Css NA 1.23 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020820 Css NA 0.1723 mg/L PBTK NA 50% Rat Human -DTXSID4020820 Css NA 0.7523 mg/L PBTK NA 95% Rat Human +DTXSID4020820 TK.Half.Life NA 2.51 hours 1compartment NA NA Rat Human +DTXSID4020820 Css NA 0.02166 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020820 Css NA 0.1865 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020820 Css NA 0.01604 mg/L PBTK NA 50% Rat Human +DTXSID4020820 Css NA 0.1158 mg/L PBTK NA 95% Rat Human DTXSID4020822 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020822 Fup 0.432 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020822 Vd NA 0.5056 L/kg 1compartment NA NA Human Human DTXSID4020822 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4020822 TK.Half.Life NA 7.573 hours 1compartment NA NA Human Human -DTXSID4020822 Css NA 1.129 mg/L 3compartmentss NA 50% Human Human -DTXSID4020822 Css NA 3.504 mg/L 3compartmentss NA 95% Human Human -DTXSID4020822 Css NA 0.8252 mg/L PBTK NA 50% Human Human -DTXSID4020822 Css NA 2.322 mg/L PBTK NA 95% Human Human +DTXSID4020822 Css NA 1.101 mg/L 3compartmentss NA 50% Human Human +DTXSID4020822 Css NA 3.294 mg/L 3compartmentss NA 95% Human Human +DTXSID4020822 Css NA 0.7818 mg/L PBTK NA 50% Human Human +DTXSID4020822 Css NA 2.339 mg/L PBTK NA 95% Human Human DTXSID4020822 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020822 Fup 0.432 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020822 Vd NA 0.5223 L/kg 1compartment NA NA Rat Human DTXSID4020822 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4020822 TK.Half.Life NA 2.666 hours 1compartment NA NA Rat Human -DTXSID4020822 Css NA 0.4312 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020822 Css NA 1.052 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020822 Css NA 0.3016 mg/L PBTK NA 50% Rat Human -DTXSID4020822 Css NA 0.6462 mg/L PBTK NA 95% Rat Human -DTXSID4020826 Clint NA 4.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020826 Fup NA 0.804 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020826 Vd NA 1.161 L/kg 1compartment NA NA Human Human +DTXSID4020822 Css NA 0.007576 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020822 Css NA 0.0373 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020822 Css NA 0.005396 mg/L PBTK NA 50% Rat Human +DTXSID4020822 Css NA 0.02685 mg/L PBTK NA 95% Rat Human +DTXSID4020826 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020826 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020826 Vd NA 0.8399 L/kg 1compartment NA NA Human Human DTXSID4020826 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020826 TK.Half.Life NA 1.723 hours 1compartment NA NA Human Human -DTXSID4020826 Css NA 0.1247 mg/L 3compartmentss NA 50% Human Human -DTXSID4020826 Css NA 0.9936 mg/L 3compartmentss NA 95% Human Human -DTXSID4020826 Css NA 0.1086 mg/L PBTK NA 50% Human Human -DTXSID4020826 Css NA 0.6891 mg/L PBTK NA 95% Human Human -DTXSID4020826 Clint NA 4.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020826 Fup NA 0.804 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020826 Vd NA 1.094 L/kg 1compartment NA NA Rat Human +DTXSID4020826 TK.Half.Life NA 0.8642 hours 1compartment NA NA Human Human +DTXSID4020826 Css NA 0.04146 mg/L 3compartmentss NA 50% Human Human +DTXSID4020826 Css NA 0.3549 mg/L 3compartmentss NA 95% Human Human +DTXSID4020826 Css NA 0.03233 mg/L PBTK NA 50% Human Human +DTXSID4020826 Css NA 0.2472 mg/L PBTK NA 95% Human Human +DTXSID4020826 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020826 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020826 Vd NA 0.7867 L/kg 1compartment NA NA Rat Human DTXSID4020826 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020826 TK.Half.Life NA 0.8483 hours 1compartment NA NA Rat Human -DTXSID4020826 Css NA 0.05683 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020826 Css NA 0.408 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020826 Css NA 0.04964 mg/L PBTK NA 50% Rat Human -DTXSID4020826 Css NA 0.258 mg/L PBTK NA 95% Rat Human +DTXSID4020826 TK.Half.Life NA 0.4097 hours 1compartment NA NA Rat Human +DTXSID4020826 Css NA 0.005023 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020826 Css NA 0.03528 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020826 Css NA 0.003945 mg/L PBTK NA 50% Rat Human +DTXSID4020826 Css NA 0.02402 mg/L PBTK NA 95% Rat Human DTXSID4020828 Clint 36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4020828 Fup NA 0.5811 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020828 Vd NA 1.414 L/kg 1compartment NA NA Human Human +DTXSID4020828 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020828 Vd NA 1.204 L/kg 1compartment NA NA Human Human DTXSID4020828 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020828 TK.Half.Life NA 1.127 hours 1compartment NA NA Human Human -DTXSID4020828 Css NA 0.02372 mg/L 3compartmentss NA 50% Human Human -DTXSID4020828 Css NA 0.2686 mg/L 3compartmentss NA 95% Human Human -DTXSID4020828 Css NA 0.02011 mg/L PBTK NA 50% Human Human -DTXSID4020828 Css NA 0.1925 mg/L PBTK NA 95% Human Human +DTXSID4020828 TK.Half.Life NA 1.1 hours 1compartment NA NA Human Human +DTXSID4020828 Css NA 0.02794 mg/L 3compartmentss NA 50% Human Human +DTXSID4020828 Css NA 0.2759 mg/L 3compartmentss NA 95% Human Human +DTXSID4020828 Css NA 0.02223 mg/L PBTK NA 50% Human Human +DTXSID4020828 Css NA 0.1983 mg/L PBTK NA 95% Human Human DTXSID4020828 Clint 36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4020828 Fup NA 0.5811 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020828 Vd NA 1.227 L/kg 1compartment NA NA Rat Human +DTXSID4020828 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020828 Vd NA 1.041 L/kg 1compartment NA NA Rat Human DTXSID4020828 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020828 TK.Half.Life NA 0.4575 hours 1compartment NA NA Rat Human -DTXSID4020828 Css NA 0.01257 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020828 Css NA 0.1267 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020828 Css NA 0.0105 mg/L PBTK NA 50% Rat Human -DTXSID4020828 Css NA 0.08638 mg/L PBTK NA 95% Rat Human +DTXSID4020828 TK.Half.Life NA 0.4569 hours 1compartment NA NA Rat Human +DTXSID4020828 Css NA 0.003486 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020828 Css NA 0.02909 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020828 Css NA 0.002846 mg/L PBTK NA 50% Rat Human +DTXSID4020828 Css NA 0.02041 mg/L PBTK NA 95% Rat Human DTXSID4020870 Clint 22.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020870 Fup 2.14e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4020870 Vd NA 3.735 L/kg 1compartment NA NA Human Human DTXSID4020870 Days.Css NA 27 Days PBTK NA NA Human Human DTXSID4020870 TK.Half.Life NA 147.4 hours 1compartment NA NA Human Human -DTXSID4020870 Css NA 4.054 mg/L 3compartmentss NA 50% Human Human -DTXSID4020870 Css NA 22.28 mg/L 3compartmentss NA 95% Human Human -DTXSID4020870 Css NA 2.995 mg/L PBTK NA 50% Human Human -DTXSID4020870 Css NA 16.61 mg/L PBTK NA 95% Human Human +DTXSID4020870 Css NA 3.94 mg/L 3compartmentss NA 50% Human Human +DTXSID4020870 Css NA 23.05 mg/L 3compartmentss NA 95% Human Human +DTXSID4020870 Css NA 2.917 mg/L PBTK NA 50% Human Human +DTXSID4020870 Css NA 16.87 mg/L PBTK NA 95% Human Human DTXSID4020870 Clint 22.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020870 Fup 2.14e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4020870 Vd NA 2.817 L/kg 1compartment NA NA Rat Human DTXSID4020870 Days.Css NA 15 Days PBTK NA NA Rat Human DTXSID4020870 TK.Half.Life NA 77.48 hours 1compartment NA NA Rat Human -DTXSID4020870 Css NA 2.289 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020870 Css NA 10.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020870 Css NA 1.63 mg/L PBTK NA 50% Rat Human -DTXSID4020870 Css NA 7.36 mg/L PBTK NA 95% Rat Human -DTXSID4020876 Clint NA 2.999 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020876 Fup NA 0.7071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020876 Vd NA 1.064 L/kg 1compartment NA NA Human Human +DTXSID4020870 Css NA 0.5154 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020870 Css NA 2.561 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020870 Css NA 0.3796 mg/L PBTK NA 50% Rat Human +DTXSID4020870 Css NA 1.905 mg/L PBTK NA 95% Rat Human +DTXSID4020876 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020876 Fup 0.507 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020876 Vd NA 0.873 L/kg 1compartment NA NA Human Human DTXSID4020876 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020876 TK.Half.Life NA 2.118 hours 1compartment NA NA Human Human -DTXSID4020876 Css NA 0.182 mg/L 3compartmentss NA 50% Human Human -DTXSID4020876 Css NA 1.423 mg/L 3compartmentss NA 95% Human Human -DTXSID4020876 Css NA 0.1562 mg/L PBTK NA 50% Human Human -DTXSID4020876 Css NA 0.9745 mg/L PBTK NA 95% Human Human -DTXSID4020876 Clint NA 2.999 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020876 Fup NA 0.7071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020876 Vd NA 1.004 L/kg 1compartment NA NA Rat Human +DTXSID4020876 TK.Half.Life NA 0.8532 hours 1compartment NA NA Human Human +DTXSID4020876 Css NA 0.03702 mg/L 3compartmentss NA 50% Human Human +DTXSID4020876 Css NA 0.3481 mg/L 3compartmentss NA 95% Human Human +DTXSID4020876 Css NA 0.02944 mg/L PBTK NA 50% Human Human +DTXSID4020876 Css NA 0.2455 mg/L PBTK NA 95% Human Human +DTXSID4020876 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020876 Fup 0.507 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020876 Vd NA 0.8215 L/kg 1compartment NA NA Rat Human DTXSID4020876 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020876 TK.Half.Life NA 1.048 hours 1compartment NA NA Rat Human -DTXSID4020876 Css NA 0.08033 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020876 Css NA 0.5874 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020876 Css NA 0.06767 mg/L PBTK NA 50% Rat Human -DTXSID4020876 Css NA 0.3613 mg/L PBTK NA 95% Rat Human +DTXSID4020876 TK.Half.Life NA 0.4032 hours 1compartment NA NA Rat Human +DTXSID4020876 Css NA 0.00464 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020876 Css NA 0.03577 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020876 Css NA 0.003718 mg/L PBTK NA 50% Rat Human +DTXSID4020876 Css NA 0.02385 mg/L PBTK NA 95% Rat Human DTXSID4020901 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020901 Fup NA 0.4809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4020901 Vd NA 0.5234 L/kg 1compartment NA NA Human Human DTXSID4020901 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4020901 TK.Half.Life NA 7.042 hours 1compartment NA NA Human Human -DTXSID4020901 Css NA 1.5 mg/L 3compartmentss NA 50% Human Human -DTXSID4020901 Css NA 7.256 mg/L 3compartmentss NA 95% Human Human -DTXSID4020901 Css NA 1.135 mg/L PBTK NA 50% Human Human -DTXSID4020901 Css NA 4.644 mg/L PBTK NA 95% Human Human +DTXSID4020901 Css NA 1.273 mg/L 3compartmentss NA 50% Human Human +DTXSID4020901 Css NA 6.518 mg/L 3compartmentss NA 95% Human Human +DTXSID4020901 Css NA 0.9597 mg/L PBTK NA 50% Human Human +DTXSID4020901 Css NA 4.145 mg/L PBTK NA 95% Human Human DTXSID4020901 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020901 Fup NA 0.4809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4020901 Vd NA 0.5373 L/kg 1compartment NA NA Rat Human DTXSID4020901 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4020901 TK.Half.Life NA 2.463 hours 1compartment NA NA Rat Human -DTXSID4020901 Css NA 0.4106 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020901 Css NA 1.788 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020901 Css NA 0.2959 mg/L PBTK NA 50% Rat Human -DTXSID4020901 Css NA 1.056 mg/L PBTK NA 95% Rat Human -DTXSID4020957 Clint NA 54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020957 Fup NA 0.7235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020957 Vd NA 0.915 L/kg 1compartment NA NA Human Human +DTXSID4020901 Css NA 0.02378 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020901 Css NA 0.1615 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020901 Css NA 0.01725 mg/L PBTK NA 50% Rat Human +DTXSID4020901 Css NA 0.1043 mg/L PBTK NA 95% Rat Human +DTXSID4020957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020957 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020957 Vd NA 0.6381 L/kg 1compartment NA NA Human Human DTXSID4020957 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020957 TK.Half.Life NA 0.6228 hours 1compartment NA NA Human Human -DTXSID4020957 Css NA 0.01233 mg/L 3compartmentss NA 50% Human Human -DTXSID4020957 Css NA 0.1354 mg/L 3compartmentss NA 95% Human Human -DTXSID4020957 Css NA 0.0103 mg/L PBTK NA 50% Human Human -DTXSID4020957 Css NA 0.09786 mg/L PBTK NA 95% Human Human -DTXSID4020957 Clint NA 54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020957 Fup NA 0.7235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4020957 Vd NA 0.8958 L/kg 1compartment NA NA Rat Human +DTXSID4020957 TK.Half.Life NA 0.7256 hours 1compartment NA NA Human Human +DTXSID4020957 Css NA 0.05034 mg/L 3compartmentss NA 50% Human Human +DTXSID4020957 Css NA 0.3959 mg/L 3compartmentss NA 95% Human Human +DTXSID4020957 Css NA 0.03706 mg/L PBTK NA 50% Human Human +DTXSID4020957 Css NA 0.2646 mg/L PBTK NA 95% Human Human +DTXSID4020957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020957 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4020957 Vd NA 0.6219 L/kg 1compartment NA NA Rat Human DTXSID4020957 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4020957 TK.Half.Life NA 0.2802 hours 1compartment NA NA Rat Human -DTXSID4020957 Css NA 0.00627 mg/L 3compartmentss NA 50% Rat Human -DTXSID4020957 Css NA 0.06311 mg/L 3compartmentss NA 95% Rat Human -DTXSID4020957 Css NA 0.005174 mg/L PBTK NA 50% Rat Human -DTXSID4020957 Css NA 0.0423 mg/L PBTK NA 95% Rat Human +DTXSID4020957 TK.Half.Life NA 0.3646 hours 1compartment NA NA Rat Human +DTXSID4020957 Css NA 0.006163 mg/L 3compartmentss NA 50% Rat Human +DTXSID4020957 Css NA 0.0389 mg/L 3compartmentss NA 95% Rat Human +DTXSID4020957 Css NA 0.004556 mg/L PBTK NA 50% Rat Human +DTXSID4020957 Css NA 0.02584 mg/L PBTK NA 95% Rat Human DTXSID4020959 Clint 22.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4020959 Fup NA 0.4087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4020959 Vd NA 1.446 L/kg 1compartment NA NA Human Human +DTXSID4020959 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4020959 Vd NA 1.025 L/kg 1compartment NA NA Human Human DTXSID4020959 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4020959 TK.Half.Life NA 1.62 hours 1compartment NA NA Human Human -DTXSID4020959 Css NA 0.05373 mg/L 3compartmentss NA 50% Human Human -DTXSID4020959 Css NA 0.3799 mg/L 3compartmentss NA 95% Human Human -DTXSID4020959 Css NA 0.04286 mg/L PBTK NA 50% Human Human -DTXSID4020959 Css NA 0.2701 mg/L PBTK NA 95% Human Human +DTXSID4020959 TK.Half.Life NA 1.604 hours 1compartment NA NA Human Human +DTXSID4020959 Css NA 0.09806 mg/L 3compartmentss NA 50% Human Human +DTXSID4020959 Css NA 0.6666 mg/L 3compartmentss NA 95% Human Human +DTXSID4020959 Css NA 0.06937 mg/L PBTK NA 50% Human Human +DTXSID4020959 Css NA 0.4448 mg/L PBTK NA 95% Human Human DTXSID4020959 Clint 14.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4020959 Fup 0.182 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID4020959 Vd NA 0.7772 L/kg 1compartment NA NA Rat Rat +DTXSID4020959 Vd NA 0.7714 L/kg 1compartment NA NA Rat Rat DTXSID4020959 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4020959 TK.Half.Life NA 0.9461 hours 1compartment NA NA Rat Rat -DTXSID4020959 Css NA 0.1018 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4020959 Css NA 0.5154 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4020959 Css NA 0.06703 mg/L PBTK NA 50% Rat Rat -DTXSID4020959 Css NA 0.315 mg/L PBTK NA 95% Rat Rat -DTXSID4021002 Clint NA 139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021002 Fup NA 0.5226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021002 Vd NA 0.5792 L/kg 1compartment NA NA Human Human +DTXSID4020959 TK.Half.Life NA 0.9392 hours 1compartment NA NA Rat Rat +DTXSID4020959 Css NA 0.02296 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4020959 Css NA 0.1186 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4020959 Css NA 0.01554 mg/L PBTK NA 50% Rat Rat +DTXSID4020959 Css NA 0.07439 mg/L PBTK NA 95% Rat Rat +DTXSID4021002 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021002 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021002 Vd NA 0.4252 L/kg 1compartment NA NA Human Human DTXSID4021002 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021002 TK.Half.Life NA 0.4365 hours 1compartment NA NA Human Human -DTXSID4021002 Css NA 0.006757 mg/L 3compartmentss NA 50% Human Human -DTXSID4021002 Css NA 0.06465 mg/L 3compartmentss NA 95% Human Human -DTXSID4021002 Css NA 0.005013 mg/L PBTK NA 50% Human Human -DTXSID4021002 Css NA 0.04336 mg/L PBTK NA 95% Human Human -DTXSID4021002 Clint NA 139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021002 Fup NA 0.5226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021002 Vd NA 0.5623 L/kg 1compartment NA NA Rat Human +DTXSID4021002 TK.Half.Life NA 0.952 hours 1compartment NA NA Human Human +DTXSID4021002 Css NA 0.1919 mg/L 3compartmentss NA 50% Human Human +DTXSID4021002 Css NA 1.261 mg/L 3compartmentss NA 95% Human Human +DTXSID4021002 Css NA 0.1322 mg/L PBTK NA 50% Human Human +DTXSID4021002 Css NA 0.7943 mg/L PBTK NA 95% Human Human +DTXSID4021002 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021002 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021002 Vd NA 0.4204 L/kg 1compartment NA NA Rat Human DTXSID4021002 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021002 TK.Half.Life NA 0.1893 hours 1compartment NA NA Rat Human -DTXSID4021002 Css NA 0.003624 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021002 Css NA 0.0318 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021002 Css NA 0.002599 mg/L PBTK NA 50% Rat Human -DTXSID4021002 Css NA 0.01976 mg/L PBTK NA 95% Rat Human +DTXSID4021002 TK.Half.Life NA 0.5271 hours 1compartment NA NA Rat Human +DTXSID4021002 Css NA 0.02258 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021002 Css NA 0.1073 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021002 Css NA 0.01537 mg/L PBTK NA 50% Rat Human +DTXSID4021002 Css NA 0.06647 mg/L PBTK NA 95% Rat Human DTXSID4021006 Clint NA 0.006949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021006 Fup NA 0.95 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021006 Vd NA 0.8412 L/kg 1compartment NA NA Human Human DTXSID4021006 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4021006 TK.Half.Life NA 5.696 hours 1compartment NA NA Human Human -DTXSID4021006 Css NA 0.8702 mg/L 3compartmentss NA 50% Human Human -DTXSID4021006 Css NA 4.876 mg/L 3compartmentss NA 95% Human Human -DTXSID4021006 Css NA 0.7307 mg/L PBTK NA 50% Human Human -DTXSID4021006 Css NA 3.232 mg/L PBTK NA 95% Human Human +DTXSID4021006 Css NA 0.7486 mg/L 3compartmentss NA 50% Human Human +DTXSID4021006 Css NA 4.192 mg/L 3compartmentss NA 95% Human Human +DTXSID4021006 Css NA 0.6285 mg/L PBTK NA 50% Human Human +DTXSID4021006 Css NA 2.809 mg/L PBTK NA 95% Human Human DTXSID4021006 Clint NA 0.006949 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021006 Fup NA 0.95 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021006 Vd NA 0.855 L/kg 1compartment NA NA Rat Human DTXSID4021006 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4021006 TK.Half.Life NA 1.975 hours 1compartment NA NA Rat Human -DTXSID4021006 Css NA 0.2223 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021006 Css NA 1.261 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021006 Css NA 0.1827 mg/L PBTK NA 50% Rat Human -DTXSID4021006 Css NA 0.7653 mg/L PBTK NA 95% Rat Human -DTXSID4021056 Clint NA 0.09244 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021056 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021056 Vd NA 0.8599 L/kg 1compartment NA NA Human Human +DTXSID4021006 Css NA 0.014 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021006 Css NA 0.1024 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021006 Css NA 0.01131 mg/L PBTK NA 50% Rat Human +DTXSID4021006 Css NA 0.06929 mg/L PBTK NA 95% Rat Human +DTXSID4021056 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021056 Fup 0.788 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021056 Vd NA 0.7438 L/kg 1compartment NA NA Human Human DTXSID4021056 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021056 TK.Half.Life NA 4.847 hours 1compartment NA NA Human Human -DTXSID4021056 Css NA 0.6822 mg/L 3compartmentss NA 50% Human Human -DTXSID4021056 Css NA 4.513 mg/L 3compartmentss NA 95% Human Human -DTXSID4021056 Css NA 0.5887 mg/L PBTK NA 50% Human Human -DTXSID4021056 Css NA 2.929 mg/L PBTK NA 95% Human Human -DTXSID4021056 Clint NA 0.09244 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021056 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021056 Vd NA 0.8866 L/kg 1compartment NA NA Rat Human +DTXSID4021056 TK.Half.Life NA 6.118 hours 1compartment NA NA Human Human +DTXSID4021056 Css NA 0.8482 mg/L 3compartmentss NA 50% Human Human +DTXSID4021056 Css NA 5.286 mg/L 3compartmentss NA 95% Human Human +DTXSID4021056 Css NA 0.6984 mg/L PBTK NA 50% Human Human +DTXSID4021056 Css NA 3.44 mg/L PBTK NA 95% Human Human +DTXSID4021056 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021056 Fup 0.788 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021056 Vd NA 0.7656 L/kg 1compartment NA NA Rat Human DTXSID4021056 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021056 TK.Half.Life NA 1.822 hours 1compartment NA NA Rat Human -DTXSID4021056 Css NA 0.1891 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021056 Css NA 1.192 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021056 Css NA 0.1601 mg/L PBTK NA 50% Rat Human -DTXSID4021056 Css NA 0.7241 mg/L PBTK NA 95% Rat Human -DTXSID4021131 Clint NA 39.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021131 Fup NA 0.0298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021131 Vd NA 2.799 L/kg 1compartment NA NA Human Human -DTXSID4021131 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4021131 TK.Half.Life NA 20.48 hours 1compartment NA NA Human Human -DTXSID4021131 Css NA 0.9218 mg/L 3compartmentss NA 50% Human Human -DTXSID4021131 Css NA 6.304 mg/L 3compartmentss NA 95% Human Human -DTXSID4021131 Css NA 0.6264 mg/L PBTK NA 50% Human Human -DTXSID4021131 Css NA 4.1 mg/L PBTK NA 95% Human Human -DTXSID4021131 Clint NA 39.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021131 Fup NA 0.0298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021131 Vd NA 2.1 L/kg 1compartment NA NA Rat Human -DTXSID4021131 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4021131 TK.Half.Life NA 4.273 hours 1compartment NA NA Rat Human -DTXSID4021131 Css NA 0.5139 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021131 Css NA 2.907 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021131 Css NA 0.3331 mg/L PBTK NA 50% Rat Human -DTXSID4021131 Css NA 1.811 mg/L PBTK NA 95% Rat Human -DTXSID4021133 Clint NA 1.917 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021133 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021133 Vd NA 1.915 L/kg 1compartment NA NA Human Human -DTXSID4021133 Days.Css NA 41 Days PBTK NA NA Human Human -DTXSID4021133 TK.Half.Life NA 198.7 hours 1compartment NA NA Human Human -DTXSID4021133 Css NA 16.99 mg/L 3compartmentss NA 50% Human Human -DTXSID4021133 Css NA 101.2 mg/L 3compartmentss NA 95% Human Human -DTXSID4021133 Css NA 10.92 mg/L PBTK NA 50% Human Human -DTXSID4021133 Css NA 60.9 mg/L PBTK NA 95% Human Human -DTXSID4021133 Clint NA 1.917 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021133 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021133 Vd NA 1.421 L/kg 1compartment NA NA Rat Human -DTXSID4021133 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID4021133 TK.Half.Life NA 58.49 hours 1compartment NA NA Rat Human -DTXSID4021133 Css NA 8.246 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021133 Css NA 38.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021133 Css NA 4.972 mg/L PBTK NA 50% Rat Human -DTXSID4021133 Css NA 21.43 mg/L PBTK NA 95% Rat Human +DTXSID4021056 TK.Half.Life NA 2.143 hours 1compartment NA NA Rat Human +DTXSID4021056 Css NA 0.01595 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021056 Css NA 0.1261 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021056 Css NA 0.01267 mg/L PBTK NA 50% Rat Human +DTXSID4021056 Css NA 0.08218 mg/L PBTK NA 95% Rat Human +DTXSID4021131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021131 Fup 0.0156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021131 Vd NA 2.747 L/kg 1compartment NA NA Human Human +DTXSID4021131 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4021131 TK.Half.Life NA 45.39 hours 1compartment NA NA Human Human +DTXSID4021131 Css NA 2.182 mg/L 3compartmentss NA 50% Human Human +DTXSID4021131 Css NA 15.76 mg/L 3compartmentss NA 95% Human Human +DTXSID4021131 Css NA 1.467 mg/L PBTK NA 50% Human Human +DTXSID4021131 Css NA 9.951 mg/L PBTK NA 95% Human Human +DTXSID4021131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021131 Fup 0.0156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021131 Vd NA 2.052 L/kg 1compartment NA NA Rat Human +DTXSID4021131 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4021131 TK.Half.Life NA 9.29 hours 1compartment NA NA Rat Human +DTXSID4021131 Css NA 0.2851 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021131 Css NA 1.699 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021131 Css NA 0.1888 mg/L PBTK NA 50% Rat Human +DTXSID4021131 Css NA 1.094 mg/L PBTK NA 95% Rat Human +DTXSID4021133 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021133 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021133 Vd NA 1.858 L/kg 1compartment NA NA Human Human +DTXSID4021133 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4021133 TK.Half.Life NA 21.05 hours 1compartment NA NA Human Human +DTXSID4021133 Css NA 1.716 mg/L 3compartmentss NA 50% Human Human +DTXSID4021133 Css NA 14.87 mg/L 3compartmentss NA 95% Human Human +DTXSID4021133 Css NA 1.088 mg/L PBTK NA 50% Human Human +DTXSID4021133 Css NA 9.072 mg/L PBTK NA 95% Human Human +DTXSID4021133 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021133 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021133 Vd NA 1.378 L/kg 1compartment NA NA Rat Human +DTXSID4021133 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4021133 TK.Half.Life NA 7.155 hours 1compartment NA NA Rat Human +DTXSID4021133 Css NA 0.2228 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021133 Css NA 1.509 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021133 Css NA 0.1381 mg/L PBTK NA 50% Rat Human +DTXSID4021133 Css NA 0.8931 mg/L PBTK NA 95% Rat Human DTXSID4021135 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4021135 Fup 0.00277 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4021135 Vd NA 0.8877 L/kg 1compartment NA NA Human Human -DTXSID4021135 Days.Css NA 644 Days PBTK NA NA Human Human -DTXSID4021135 TK.Half.Life NA 2380 hours 1compartment NA NA Human Human -DTXSID4021135 Css NA 339.3 mg/L 3compartmentss NA 50% Human Human -DTXSID4021135 Css NA 1623 mg/L 3compartmentss NA 95% Human Human -DTXSID4021135 Css NA 204.1 mg/L PBTK NA 50% Human Human -DTXSID4021135 Css NA 941.8 mg/L PBTK NA 95% Human Human +DTXSID4021135 Vd NA 2.118 L/kg 1compartment NA NA Human Human +DTXSID4021135 Days.Css NA 2967 Days PBTK NA NA Human Human +DTXSID4021135 TK.Half.Life NA 10890 hours 1compartment NA NA Human Human +DTXSID4021135 Css NA 621.9 mg/L 3compartmentss NA 50% Human Human +DTXSID4021135 Css NA 2172 mg/L 3compartmentss NA 95% Human Human +DTXSID4021135 Css NA 402.6 mg/L PBTK NA 50% Human Human +DTXSID4021135 Css NA 1331 mg/L PBTK NA 95% Human Human DTXSID4021135 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4021135 Fup 0.00277 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4021135 Vd NA 0.6499 L/kg 1compartment NA NA Rat Human -DTXSID4021135 Days.Css NA 154 Days PBTK NA NA Rat Human -DTXSID4021135 TK.Half.Life NA 535.2 hours 1compartment NA NA Rat Human -DTXSID4021135 Css NA 96.84 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021135 Css NA 377.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021135 Css NA 54.3 mg/L PBTK NA 50% Rat Human -DTXSID4021135 Css NA 205.9 mg/L PBTK NA 95% Rat Human +DTXSID4021135 Vd NA 1.567 L/kg 1compartment NA NA Rat Human +DTXSID4021135 Days.Css NA 751 Days PBTK NA NA Rat Human +DTXSID4021135 TK.Half.Life NA 1605 hours 1compartment NA NA Rat Human +DTXSID4021135 Css NA 39.72 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021135 Css NA 117 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021135 Css NA 25.14 mg/L PBTK NA 50% Rat Human +DTXSID4021135 Css NA 68.59 mg/L PBTK NA 95% Rat Human DTXSID4021137 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4021137 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021137 Vd NA 0.8969 L/kg 1compartment NA NA Human Human +DTXSID4021137 Fup 0.644 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021137 Vd NA 0.6863 L/kg 1compartment NA NA Human Human DTXSID4021137 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021137 TK.Half.Life NA 5.82 hours 1compartment NA NA Human Human -DTXSID4021137 Css NA 0.7885 mg/L 3compartmentss NA 50% Human Human -DTXSID4021137 Css NA 5.471 mg/L 3compartmentss NA 95% Human Human -DTXSID4021137 Css NA 0.6828 mg/L PBTK NA 50% Human Human -DTXSID4021137 Css NA 3.566 mg/L PBTK NA 95% Human Human +DTXSID4021137 TK.Half.Life NA 6.911 hours 1compartment NA NA Human Human +DTXSID4021137 Css NA 0.9654 mg/L 3compartmentss NA 50% Human Human +DTXSID4021137 Css NA 6.546 mg/L 3compartmentss NA 95% Human Human +DTXSID4021137 Css NA 0.7766 mg/L PBTK NA 50% Human Human +DTXSID4021137 Css NA 4.184 mg/L PBTK NA 95% Human Human DTXSID4021137 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4021137 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021137 Vd NA 0.9201 L/kg 1compartment NA NA Rat Human +DTXSID4021137 Fup 0.644 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021137 Vd NA 0.703 L/kg 1compartment NA NA Rat Human DTXSID4021137 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021137 TK.Half.Life NA 2.03 hours 1compartment NA NA Rat Human -DTXSID4021137 Css NA 0.199 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021137 Css NA 1.181 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021137 Css NA 0.1705 mg/L PBTK NA 50% Rat Human -DTXSID4021137 Css NA 0.7258 mg/L PBTK NA 95% Rat Human -DTXSID4021139 Clint NA 0.8081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021139 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021139 Vd NA 0.8969 L/kg 1compartment NA NA Human Human +DTXSID4021137 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human +DTXSID4021137 Css NA 0.01809 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021137 Css NA 0.1632 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021137 Css NA 0.01403 mg/L PBTK NA 50% Rat Human +DTXSID4021137 Css NA 0.1025 mg/L PBTK NA 95% Rat Human +DTXSID4021139 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021139 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021139 Vd NA 0.7366 L/kg 1compartment NA NA Human Human DTXSID4021139 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021139 TK.Half.Life NA 2.655 hours 1compartment NA NA Human Human -DTXSID4021139 Css NA 0.3441 mg/L 3compartmentss NA 50% Human Human -DTXSID4021139 Css NA 2.35 mg/L 3compartmentss NA 95% Human Human -DTXSID4021139 Css NA 0.297 mg/L PBTK NA 50% Human Human -DTXSID4021139 Css NA 1.601 mg/L PBTK NA 95% Human Human -DTXSID4021139 Clint NA 0.8081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021139 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021139 Vd NA 0.9201 L/kg 1compartment NA NA Rat Human +DTXSID4021139 TK.Half.Life NA 0.6515 hours 1compartment NA NA Human Human +DTXSID4021139 Css NA 0.02516 mg/L 3compartmentss NA 50% Human Human +DTXSID4021139 Css NA 0.3194 mg/L 3compartmentss NA 95% Human Human +DTXSID4021139 Css NA 0.02001 mg/L PBTK NA 50% Human Human +DTXSID4021139 Css NA 0.2156 mg/L PBTK NA 95% Human Human +DTXSID4021139 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021139 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021139 Vd NA 0.7431 L/kg 1compartment NA NA Rat Human DTXSID4021139 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021139 TK.Half.Life NA 1.266 hours 1compartment NA NA Rat Human -DTXSID4021139 Css NA 0.1244 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021139 Css NA 0.7906 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021139 Css NA 0.1064 mg/L PBTK NA 50% Rat Human -DTXSID4021139 Css NA 0.4852 mg/L PBTK NA 95% Rat Human -DTXSID4021181 Clint NA 14.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021181 Fup NA 0.0346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021181 Vd NA 2.224 L/kg 1compartment NA NA Human Human -DTXSID4021181 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4021181 TK.Half.Life NA 24.38 hours 1compartment NA NA Human Human -DTXSID4021181 Css NA 1.588 mg/L 3compartmentss NA 50% Human Human -DTXSID4021181 Css NA 10.76 mg/L 3compartmentss NA 95% Human Human -DTXSID4021181 Css NA 1.043 mg/L PBTK NA 50% Human Human -DTXSID4021181 Css NA 6.789 mg/L PBTK NA 95% Human Human -DTXSID4021181 Clint NA 14.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021181 Fup NA 0.0346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021181 Vd NA 1.661 L/kg 1compartment NA NA Rat Human -DTXSID4021181 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4021181 TK.Half.Life NA 7.055 hours 1compartment NA NA Rat Human -DTXSID4021181 Css NA 0.8832 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021181 Css NA 4.427 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021181 Css NA 0.5498 mg/L PBTK NA 50% Rat Human -DTXSID4021181 Css NA 2.669 mg/L PBTK NA 95% Rat Human +DTXSID4021139 TK.Half.Life NA 0.3245 hours 1compartment NA NA Rat Human +DTXSID4021139 Css NA 0.0009128 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021139 Css NA 0.01214 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021139 Css NA 0.0007226 mg/L PBTK NA 50% Rat Human +DTXSID4021139 Css NA 0.008181 mg/L PBTK NA 95% Rat Human +DTXSID4021181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021181 Fup 0.0163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021181 Vd NA 1.734 L/kg 1compartment NA NA Human Human +DTXSID4021181 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4021181 TK.Half.Life NA 19.12 hours 1compartment NA NA Human Human +DTXSID4021181 Css NA 1.684 mg/L 3compartmentss NA 50% Human Human +DTXSID4021181 Css NA 14.95 mg/L 3compartmentss NA 95% Human Human +DTXSID4021181 Css NA 1.065 mg/L PBTK NA 50% Human Human +DTXSID4021181 Css NA 9.024 mg/L PBTK NA 95% Human Human +DTXSID4021181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021181 Fup 0.0163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021181 Vd NA 1.285 L/kg 1compartment NA NA Rat Human +DTXSID4021181 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4021181 TK.Half.Life NA 6.816 hours 1compartment NA NA Rat Human +DTXSID4021181 Css NA 0.2204 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021181 Css NA 1.517 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021181 Css NA 0.1354 mg/L PBTK NA 50% Rat Human +DTXSID4021181 Css NA 0.8962 mg/L PBTK NA 95% Rat Human DTXSID4021185 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4021185 Fup 0.4818 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID4021185 Vd NA 1.162 L/kg 1compartment NA NA Human Human +DTXSID4021185 Vd NA 1.154 L/kg 1compartment NA NA Human Human DTXSID4021185 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4021185 TK.Half.Life NA 17.16 hours 1compartment NA NA Human Human -DTXSID4021185 Css NA 1.489 mg/L 3compartmentss NA 50% Human Human -DTXSID4021185 Css NA 7.274 mg/L 3compartmentss NA 95% Human Human -DTXSID4021185 Css NA 1.208 mg/L PBTK NA 50% Human Human -DTXSID4021185 Css NA 4.764 mg/L PBTK NA 95% Human Human +DTXSID4021185 TK.Half.Life NA 17.01 hours 1compartment NA NA Human Human +DTXSID4021185 Css NA 1.445 mg/L 3compartmentss NA 50% Human Human +DTXSID4021185 Css NA 5.668 mg/L 3compartmentss NA 95% Human Human +DTXSID4021185 Css NA 1.199 mg/L PBTK NA 50% Human Human +DTXSID4021185 Css NA 4.704 mg/L PBTK NA 95% Human Human DTXSID4021185 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID4021185 Fup 0.4818 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID4021185 Vd NA 1.021 L/kg 1compartment NA NA Rat Human +DTXSID4021185 Vd NA 1.016 L/kg 1compartment NA NA Rat Human DTXSID4021185 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021185 TK.Half.Life NA 4.784 hours 1compartment NA NA Rat Human -DTXSID4021185 Css NA 0.4111 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021185 Css NA 1.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021185 Css NA 0.3214 mg/L PBTK NA 50% Rat Human -DTXSID4021185 Css NA 1.088 mg/L PBTK NA 95% Rat Human -DTXSID4021189 Clint NA 48.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021189 Fup NA 0.6261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021189 Vd NA 1.179 L/kg 1compartment NA NA Human Human +DTXSID4021185 TK.Half.Life NA 4.757 hours 1compartment NA NA Rat Human +DTXSID4021185 Css NA 0.08696 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021185 Css NA 0.2963 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021185 Css NA 0.0747 mg/L PBTK NA 50% Rat Human +DTXSID4021185 Css NA 0.2546 mg/L PBTK NA 95% Rat Human +DTXSID4021189 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021189 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021189 Vd NA 1.256 L/kg 1compartment NA NA Human Human DTXSID4021189 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021189 TK.Half.Life NA 0.8341 hours 1compartment NA NA Human Human -DTXSID4021189 Css NA 0.015 mg/L 3compartmentss NA 50% Human Human -DTXSID4021189 Css NA 0.1674 mg/L 3compartmentss NA 95% Human Human -DTXSID4021189 Css NA 0.01264 mg/L PBTK NA 50% Human Human -DTXSID4021189 Css NA 0.1184 mg/L PBTK NA 95% Human Human -DTXSID4021189 Clint NA 48.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021189 Fup NA 0.6261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021189 Vd NA 1.188 L/kg 1compartment NA NA Rat Human +DTXSID4021189 TK.Half.Life NA 1.64 hours 1compartment NA NA Human Human +DTXSID4021189 Css NA 0.09176 mg/L 3compartmentss NA 50% Human Human +DTXSID4021189 Css NA 0.8615 mg/L 3compartmentss NA 95% Human Human +DTXSID4021189 Css NA 0.08048 mg/L PBTK NA 50% Human Human +DTXSID4021189 Css NA 0.5965 mg/L PBTK NA 95% Human Human +DTXSID4021189 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021189 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021189 Vd NA 1.268 L/kg 1compartment NA NA Rat Human DTXSID4021189 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021189 TK.Half.Life NA 0.3943 hours 1compartment NA NA Rat Human -DTXSID4021189 Css NA 0.007591 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021189 Css NA 0.07765 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021189 Css NA 0.006432 mg/L PBTK NA 50% Rat Human -DTXSID4021189 Css NA 0.052 mg/L PBTK NA 95% Rat Human -DTXSID4021212 Clint NA 0.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021212 Fup NA 0.2434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021212 Vd NA 0.3664 L/kg 1compartment NA NA Human Human +DTXSID4021189 TK.Half.Life NA 0.8924 hours 1compartment NA NA Rat Human +DTXSID4021189 Css NA 0.01004 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021189 Css NA 0.08626 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021189 Css NA 0.009065 mg/L PBTK NA 50% Rat Human +DTXSID4021189 Css NA 0.0567 mg/L PBTK NA 95% Rat Human +DTXSID4021210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021210 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4021210 Vd NA 1.232 L/kg 1compartment NA NA Human Human +DTXSID4021210 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4021210 TK.Half.Life NA 11.03 hours 1compartment NA NA Human Human +DTXSID4021210 Css NA 1.417 mg/L 3compartmentss NA 50% Human Human +DTXSID4021210 Css NA 13.03 mg/L 3compartmentss NA 95% Human Human +DTXSID4021210 Css NA 0.8713 mg/L PBTK NA 50% Human Human +DTXSID4021210 Css NA 7.691 mg/L PBTK NA 95% Human Human +DTXSID4021210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021210 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4021210 Vd NA 0.915 L/kg 1compartment NA NA Rat Human +DTXSID4021210 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4021210 TK.Half.Life NA 4.578 hours 1compartment NA NA Rat Human +DTXSID4021210 Css NA 0.1817 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021210 Css NA 1.398 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021210 Css NA 0.1089 mg/L PBTK NA 50% Rat Human +DTXSID4021210 Css NA 0.803 mg/L PBTK NA 95% Rat Human +DTXSID4021212 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021212 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021212 Vd NA 0.4738 L/kg 1compartment NA NA Human Human DTXSID4021212 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021212 TK.Half.Life NA 7.944 hours 1compartment NA NA Human Human -DTXSID4021212 Css NA 2.6 mg/L 3compartmentss NA 50% Human Human -DTXSID4021212 Css NA 9.562 mg/L 3compartmentss NA 95% Human Human -DTXSID4021212 Css NA 1.746 mg/L PBTK NA 50% Human Human -DTXSID4021212 Css NA 5.882 mg/L PBTK NA 95% Human Human -DTXSID4021212 Clint NA 0.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021212 Fup NA 0.2434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021212 Vd NA 0.3695 L/kg 1compartment NA NA Rat Human +DTXSID4021212 TK.Half.Life NA 7.514 hours 1compartment NA NA Human Human +DTXSID4021212 Css NA 0.9608 mg/L 3compartmentss NA 50% Human Human +DTXSID4021212 Css NA 4.507 mg/L 3compartmentss NA 95% Human Human +DTXSID4021212 Css NA 0.7088 mg/L PBTK NA 50% Human Human +DTXSID4021212 Css NA 2.901 mg/L PBTK NA 95% Human Human +DTXSID4021212 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021212 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021212 Vd NA 0.4795 L/kg 1compartment NA NA Rat Human DTXSID4021212 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021212 TK.Half.Life NA 3.015 hours 1compartment NA NA Rat Human -DTXSID4021212 Css NA 0.8054 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021212 Css NA 2.609 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021212 Css NA 0.512 mg/L PBTK NA 50% Rat Human -DTXSID4021212 Css NA 1.495 mg/L PBTK NA 95% Rat Human -DTXSID4021214 Clint NA 1.025 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021214 Fup NA 0.0299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021214 Vd NA 0.2621 L/kg 1compartment NA NA Human Human -DTXSID4021214 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4021214 TK.Half.Life NA 20.84 hours 1compartment NA NA Human Human -DTXSID4021214 Css NA 13.88 mg/L 3compartmentss NA 50% Human Human -DTXSID4021214 Css NA 91.89 mg/L 3compartmentss NA 95% Human Human -DTXSID4021214 Css NA 8.246 mg/L PBTK NA 50% Human Human -DTXSID4021214 Css NA 53.28 mg/L PBTK NA 95% Human Human -DTXSID4021214 Clint NA 1.025 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021214 Fup NA 0.0299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021214 Vd NA 0.236 L/kg 1compartment NA NA Rat Human -DTXSID4021214 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4021214 TK.Half.Life NA 9.45 hours 1compartment NA NA Rat Human -DTXSID4021214 Css NA 5.904 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021214 Css NA 32.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021214 Css NA 3.267 mg/L PBTK NA 50% Rat Human -DTXSID4021214 Css NA 17.57 mg/L PBTK NA 95% Rat Human -DTXSID4021216 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021216 Fup NA 0.2109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021216 Vd NA 3.481 L/kg 1compartment NA NA Human Human +DTXSID4021212 TK.Half.Life NA 2.59 hours 1compartment NA NA Rat Human +DTXSID4021212 Css NA 0.005194 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021212 Css NA 0.02536 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021212 Css NA 0.003642 mg/L PBTK NA 50% Rat Human +DTXSID4021212 Css NA 0.01537 mg/L PBTK NA 95% Rat Human +DTXSID4021214 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021214 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021214 Vd NA 0.3808 L/kg 1compartment NA NA Human Human +DTXSID4021214 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4021214 TK.Half.Life NA 2.165 hours 1compartment NA NA Human Human +DTXSID4021214 Css NA 0.8678 mg/L 3compartmentss NA 50% Human Human +DTXSID4021214 Css NA 6.838 mg/L 3compartmentss NA 95% Human Human +DTXSID4021214 Css NA 0.522 mg/L PBTK NA 50% Human Human +DTXSID4021214 Css NA 4.075 mg/L PBTK NA 95% Human Human +DTXSID4021214 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021214 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021214 Vd NA 0.3179 L/kg 1compartment NA NA Rat Human +DTXSID4021214 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4021214 TK.Half.Life NA 1.146 hours 1compartment NA NA Rat Human +DTXSID4021214 Css NA 0.1139 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021214 Css NA 0.6778 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021214 Css NA 0.06595 mg/L PBTK NA 50% Rat Human +DTXSID4021214 Css NA 0.3856 mg/L PBTK NA 95% Rat Human +DTXSID4021216 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021216 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021216 Vd NA 1.384 L/kg 1compartment NA NA Human Human DTXSID4021216 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021216 TK.Half.Life NA 6.118 hours 1compartment NA NA Human Human -DTXSID4021216 Css NA 0.1083 mg/L 3compartmentss NA 50% Human Human -DTXSID4021216 Css NA 0.7764 mg/L 3compartmentss NA 95% Human Human -DTXSID4021216 Css NA 0.1101 mg/L PBTK NA 50% Human Human -DTXSID4021216 Css NA 0.6954 mg/L PBTK NA 95% Human Human -DTXSID4021216 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021216 Fup NA 0.2109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021216 Vd NA 3.29 L/kg 1compartment NA NA Rat Human +DTXSID4021216 TK.Half.Life NA 2.483 hours 1compartment NA NA Human Human +DTXSID4021216 Css NA 0.1273 mg/L 3compartmentss NA 50% Human Human +DTXSID4021216 Css NA 0.9567 mg/L 3compartmentss NA 95% Human Human +DTXSID4021216 Css NA 0.1091 mg/L PBTK NA 50% Human Human +DTXSID4021216 Css NA 0.6723 mg/L PBTK NA 95% Human Human +DTXSID4021216 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021216 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021216 Vd NA 1.397 L/kg 1compartment NA NA Rat Human DTXSID4021216 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021216 TK.Half.Life NA 2.875 hours 1compartment NA NA Rat Human -DTXSID4021216 Css NA 0.05748 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021216 Css NA 0.3086 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021216 Css NA 0.05744 mg/L PBTK NA 50% Rat Human -DTXSID4021216 Css NA 0.2573 mg/L PBTK NA 95% Rat Human +DTXSID4021216 TK.Half.Life NA 1.409 hours 1compartment NA NA Rat Human +DTXSID4021216 Css NA 0.01471 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021216 Css NA 0.08335 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021216 Css NA 0.01276 mg/L PBTK NA 50% Rat Human +DTXSID4021216 Css NA 0.05695 mg/L PBTK NA 95% Rat Human DTXSID4021218 Clint 75.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4021218 Fup 0.0176 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4021218 Vd NA 0.2059 L/kg 1compartment NA NA Human Human +DTXSID4021218 Vd NA 0.2214 L/kg 1compartment NA NA Human Human DTXSID4021218 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021218 TK.Half.Life NA 0.7924 hours 1compartment NA NA Human Human -DTXSID4021218 Css NA 0.5544 mg/L 3compartmentss NA 50% Human Human -DTXSID4021218 Css NA 5.445 mg/L 3compartmentss NA 95% Human Human -DTXSID4021218 Css NA 0.3263 mg/L PBTK NA 50% Human Human -DTXSID4021218 Css NA 3.12 mg/L PBTK NA 95% Human Human +DTXSID4021218 TK.Half.Life NA 0.847 hours 1compartment NA NA Human Human +DTXSID4021218 Css NA 0.5192 mg/L 3compartmentss NA 50% Human Human +DTXSID4021218 Css NA 5.39 mg/L 3compartmentss NA 95% Human Human +DTXSID4021218 Css NA 0.3058 mg/L PBTK NA 50% Human Human +DTXSID4021218 Css NA 3.09 mg/L PBTK NA 95% Human Human DTXSID4021218 Clint 75.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4021218 Fup 0.0176 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4021218 Vd NA 0.1947 L/kg 1compartment NA NA Rat Human +DTXSID4021218 Vd NA 0.2043 L/kg 1compartment NA NA Rat Human DTXSID4021218 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021218 TK.Half.Life NA 0.4718 hours 1compartment NA NA Rat Human -DTXSID4021218 Css NA 0.3238 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021218 Css NA 2.441 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021218 Css NA 0.1768 mg/L PBTK NA 50% Rat Human -DTXSID4021218 Css NA 1.325 mg/L PBTK NA 95% Rat Human -DTXSID4021260 Clint NA 95.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021260 Fup NA 0.02 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021260 Vd NA 3.121 L/kg 1compartment NA NA Human Human -DTXSID4021260 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021260 TK.Half.Life NA 11.92 hours 1compartment NA NA Human Human -DTXSID4021260 Css NA 0.3754 mg/L 3compartmentss NA 50% Human Human -DTXSID4021260 Css NA 2.359 mg/L 3compartmentss NA 95% Human Human -DTXSID4021260 Css NA 0.2618 mg/L PBTK NA 50% Human Human -DTXSID4021260 Css NA 1.586 mg/L PBTK NA 95% Human Human -DTXSID4021260 Clint NA 95.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021260 Fup NA 0.02 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021260 Vd NA 2.345 L/kg 1compartment NA NA Rat Human -DTXSID4021260 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021260 TK.Half.Life NA 2.083 hours 1compartment NA NA Rat Human -DTXSID4021260 Css NA 0.2118 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021260 Css NA 1.063 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021260 Css NA 0.141 mg/L PBTK NA 50% Rat Human -DTXSID4021260 Css NA 0.684 mg/L PBTK NA 95% Rat Human -DTXSID4021264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021264 Fup NA 0.713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021264 Vd NA 2.684 L/kg 1compartment NA NA Human Human -DTXSID4021264 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID4021264 TK.Half.Life NA 70.39 hours 1compartment NA NA Human Human -DTXSID4021264 Css NA 2.684 mg/L 3compartmentss NA 50% Human Human -DTXSID4021264 Css NA 11.07 mg/L 3compartmentss NA 95% Human Human -DTXSID4021264 Css NA 2.251 mg/L PBTK NA 50% Human Human -DTXSID4021264 Css NA 7.611 mg/L PBTK NA 95% Human Human -DTXSID4021264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021264 Fup NA 0.713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021264 Vd NA 2.115 L/kg 1compartment NA NA Rat Human -DTXSID4021264 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4021264 TK.Half.Life NA 9.489 hours 1compartment NA NA Rat Human -DTXSID4021264 Css NA 0.7149 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021264 Css NA 2.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021264 Css NA 0.5846 mg/L PBTK NA 50% Rat Human -DTXSID4021264 Css NA 1.642 mg/L PBTK NA 95% Rat Human +DTXSID4021218 TK.Half.Life NA 0.4916 hours 1compartment NA NA Rat Human +DTXSID4021218 Css NA 0.05588 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021218 Css NA 0.4695 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021218 Css NA 0.03154 mg/L PBTK NA 50% Rat Human +DTXSID4021218 Css NA 0.2639 mg/L PBTK NA 95% Rat Human +DTXSID4021260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021260 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021260 Vd NA 3.065 L/kg 1compartment NA NA Human Human +DTXSID4021260 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4021260 TK.Half.Life NA 41.38 hours 1compartment NA NA Human Human +DTXSID4021260 Css NA 1.597 mg/L 3compartmentss NA 50% Human Human +DTXSID4021260 Css NA 10.88 mg/L 3compartmentss NA 95% Human Human +DTXSID4021260 Css NA 1.101 mg/L PBTK NA 50% Human Human +DTXSID4021260 Css NA 7.399 mg/L PBTK NA 95% Human Human +DTXSID4021260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021260 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021260 Vd NA 2.303 L/kg 1compartment NA NA Rat Human +DTXSID4021260 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4021260 TK.Half.Life NA 6.46 hours 1compartment NA NA Rat Human +DTXSID4021260 Css NA 0.207 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021260 Css NA 1.2 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021260 Css NA 0.142 mg/L PBTK NA 50% Rat Human +DTXSID4021260 Css NA 0.7804 mg/L PBTK NA 95% Rat Human DTXSID4021268 Clint 6.326 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4021268 Fup 0.2845 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4021268 Vd NA 1.539 L/kg 1compartment NA NA Human Human DTXSID4021268 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4021268 TK.Half.Life NA 4.475 hours 1compartment NA NA Human Human -DTXSID4021268 Css NA 0.2544 mg/L 3compartmentss NA 50% Human Human -DTXSID4021268 Css NA 1.533 mg/L 3compartmentss NA 95% Human Human -DTXSID4021268 Css NA 0.2104 mg/L PBTK NA 50% Human Human -DTXSID4021268 Css NA 1.132 mg/L PBTK NA 95% Human Human +DTXSID4021268 Css NA 0.2238 mg/L 3compartmentss NA 50% Human Human +DTXSID4021268 Css NA 1.231 mg/L 3compartmentss NA 95% Human Human +DTXSID4021268 Css NA 0.2032 mg/L PBTK NA 50% Human Human +DTXSID4021268 Css NA 1.12 mg/L PBTK NA 95% Human Human DTXSID4021268 Clint 4.832 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4021268 Fup 0.647 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID4021268 Vd NA 1.785 L/kg 1compartment NA NA Rat Rat +DTXSID4021268 Vd 3.4 1.785 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID4021268 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4021268 TK.Half.Life NA 1.655 hours 1compartment NA NA Rat Rat -DTXSID4021268 Css NA 0.1045 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4021268 Css NA 0.5798 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4021268 Css NA 0.07697 mg/L PBTK NA 50% Rat Rat -DTXSID4021268 Css NA 0.3595 mg/L PBTK NA 95% Rat Rat -DTXSID4021341 Clint NA 333.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021341 Fup NA 0.0082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021341 Vd NA 9.331 L/kg 1compartment NA NA Human Human -DTXSID4021341 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4021341 TK.Half.Life NA 22.53 hours 1compartment NA NA Human Human -DTXSID4021341 Css NA 0.1426 mg/L 3compartmentss NA 50% Human Human -DTXSID4021341 Css NA 0.8198 mg/L 3compartmentss NA 95% Human Human -DTXSID4021341 Css NA 0.1612 mg/L PBTK NA 50% Human Human -DTXSID4021341 Css NA 0.8872 mg/L PBTK NA 95% Human Human -DTXSID4021341 Clint NA 333.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021341 Fup NA 0.0082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021341 Vd NA 7.321 L/kg 1compartment NA NA Rat Human -DTXSID4021341 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4021341 TK.Half.Life NA 4.056 hours 1compartment NA NA Rat Human -DTXSID4021341 Css NA 0.07762 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021341 Css NA 0.342 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021341 Css NA 0.08708 mg/L PBTK NA 50% Rat Human -DTXSID4021341 Css NA 0.3694 mg/L PBTK NA 95% Rat Human -DTXSID4021343 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021343 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021343 Vd NA 0.3458 L/kg 1compartment NA NA Human Human -DTXSID4021343 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021343 TK.Half.Life NA 8.147 hours 1compartment NA NA Human Human -DTXSID4021343 Css NA 2.926 mg/L 3compartmentss NA 50% Human Human -DTXSID4021343 Css NA 11.09 mg/L 3compartmentss NA 95% Human Human -DTXSID4021343 Css NA 1.921 mg/L PBTK NA 50% Human Human -DTXSID4021343 Css NA 6.719 mg/L PBTK NA 95% Human Human -DTXSID4021343 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021343 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021343 Vd NA 0.3464 L/kg 1compartment NA NA Rat Human -DTXSID4021343 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021343 TK.Half.Life NA 2.779 hours 1compartment NA NA Rat Human -DTXSID4021343 Css NA 0.8088 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021343 Css NA 2.594 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021343 Css NA 0.5041 mg/L PBTK NA 50% Rat Human -DTXSID4021343 Css NA 1.474 mg/L PBTK NA 95% Rat Human -DTXSID4021347 Clint NA 0.06035 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021347 Fup NA 0.8232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021347 Vd NA 0.6683 L/kg 1compartment NA NA Human Human +DTXSID4021268 TK.Half.Life 0.31 1.655 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID4021268 Css 0.0055 0.01928 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID4021268 Css 0.0055 0.08973 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID4021268 Css 0.0055 0.01818 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID4021268 Css 0.0055 0.08462 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID4021341 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021341 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021341 Vd NA 3.062 L/kg 1compartment NA NA Human Human +DTXSID4021341 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID4021341 TK.Half.Life NA 80.85 hours 1compartment NA NA Human Human +DTXSID4021341 Css NA 3.214 mg/L 3compartmentss NA 50% Human Human +DTXSID4021341 Css NA 21.48 mg/L 3compartmentss NA 95% Human Human +DTXSID4021341 Css NA 2.205 mg/L PBTK NA 50% Human Human +DTXSID4021341 Css NA 14.43 mg/L PBTK NA 95% Human Human +DTXSID4021341 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021341 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021341 Vd NA 2.293 L/kg 1compartment NA NA Rat Human +DTXSID4021341 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID4021341 TK.Half.Life NA 11.79 hours 1compartment NA NA Rat Human +DTXSID4021341 Css NA 0.4187 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021341 Css NA 2.386 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021341 Css NA 0.2849 mg/L PBTK NA 50% Rat Human +DTXSID4021341 Css NA 1.595 mg/L PBTK NA 95% Rat Human +DTXSID4021347 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021347 Fup 0.492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021347 Vd NA 0.5818 L/kg 1compartment NA NA Human Human DTXSID4021347 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021347 TK.Half.Life NA 4.787 hours 1compartment NA NA Human Human -DTXSID4021347 Css NA 0.9078 mg/L 3compartmentss NA 50% Human Human -DTXSID4021347 Css NA 5.245 mg/L 3compartmentss NA 95% Human Human -DTXSID4021347 Css NA 0.7225 mg/L PBTK NA 50% Human Human -DTXSID4021347 Css NA 3.344 mg/L PBTK NA 95% Human Human -DTXSID4021347 Clint NA 0.06035 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021347 Fup NA 0.8232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021347 Vd NA 0.6867 L/kg 1compartment NA NA Rat Human +DTXSID4021347 TK.Half.Life NA 7.664 hours 1compartment NA NA Human Human +DTXSID4021347 Css NA 1.233 mg/L 3compartmentss NA 50% Human Human +DTXSID4021347 Css NA 6.462 mg/L 3compartmentss NA 95% Human Human +DTXSID4021347 Css NA 0.9398 mg/L PBTK NA 50% Human Human +DTXSID4021347 Css NA 4.111 mg/L PBTK NA 95% Human Human +DTXSID4021347 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021347 Fup 0.492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021347 Vd NA 0.5943 L/kg 1compartment NA NA Rat Human DTXSID4021347 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021347 TK.Half.Life NA 1.755 hours 1compartment NA NA Rat Human -DTXSID4021347 Css NA 0.246 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021347 Css NA 1.468 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021347 Css NA 0.1894 mg/L PBTK NA 50% Rat Human -DTXSID4021347 Css NA 0.866 mg/L PBTK NA 95% Rat Human -DTXSID4021391 Clint NA 74.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021391 Fup NA 0.0051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021391 Vd NA 2.985 L/kg 1compartment NA NA Human Human -DTXSID4021391 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4021391 TK.Half.Life NA 26.28 hours 1compartment NA NA Human Human -DTXSID4021391 Css NA 1.07 mg/L 3compartmentss NA 50% Human Human -DTXSID4021391 Css NA 6.763 mg/L 3compartmentss NA 95% Human Human -DTXSID4021391 Css NA 0.732 mg/L PBTK NA 50% Human Human -DTXSID4021391 Css NA 4.487 mg/L PBTK NA 95% Human Human -DTXSID4021391 Clint NA 74.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021391 Fup NA 0.0051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021391 Vd NA 2.232 L/kg 1compartment NA NA Rat Human -DTXSID4021391 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4021391 TK.Half.Life NA 4.486 hours 1compartment NA NA Rat Human -DTXSID4021391 Css NA 0.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021391 Css NA 3.003 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021391 Css NA 0.3919 mg/L PBTK NA 50% Rat Human -DTXSID4021391 Css NA 1.886 mg/L PBTK NA 95% Rat Human -DTXSID4021393 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021393 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021393 Vd NA 0.8514 L/kg 1compartment NA NA Human Human +DTXSID4021347 TK.Half.Life NA 2.665 hours 1compartment NA NA Rat Human +DTXSID4021347 Css NA 0.02336 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021347 Css NA 0.1585 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021347 Css NA 0.01702 mg/L PBTK NA 50% Rat Human +DTXSID4021347 Css NA 0.1015 mg/L PBTK NA 95% Rat Human +DTXSID4021393 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021393 Fup 0.66 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021393 Vd NA 0.6619 L/kg 1compartment NA NA Human Human DTXSID4021393 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021393 TK.Half.Life NA 5.51 hours 1compartment NA NA Human Human -DTXSID4021393 Css NA 0.822 mg/L 3compartmentss NA 50% Human Human -DTXSID4021393 Css NA 5.515 mg/L 3compartmentss NA 95% Human Human -DTXSID4021393 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID4021393 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID4021393 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021393 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021393 Vd NA 0.894 L/kg 1compartment NA NA Rat Human +DTXSID4021393 TK.Half.Life NA 6.49 hours 1compartment NA NA Human Human +DTXSID4021393 Css NA 0.9808 mg/L 3compartmentss NA 50% Human Human +DTXSID4021393 Css NA 6.328 mg/L 3compartmentss NA 95% Human Human +DTXSID4021393 Css NA 0.7804 mg/L PBTK NA 50% Human Human +DTXSID4021393 Css NA 4.041 mg/L PBTK NA 95% Human Human +DTXSID4021393 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021393 Fup 0.66 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021393 Vd NA 0.694 L/kg 1compartment NA NA Rat Human DTXSID4021393 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021393 TK.Half.Life NA 1.971 hours 1compartment NA NA Rat Human -DTXSID4021393 Css NA 0.2062 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021393 Css NA 1.304 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021393 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID4021393 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID4021397 Clint NA 1.087 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021397 Fup NA 0.0258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021397 Vd NA 0.4109 L/kg 1compartment NA NA Human Human -DTXSID4021397 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID4021397 TK.Half.Life NA 35.93 hours 1compartment NA NA Human Human -DTXSID4021397 Css NA 15.12 mg/L 3compartmentss NA 50% Human Human -DTXSID4021397 Css NA 100 mg/L 3compartmentss NA 95% Human Human -DTXSID4021397 Css NA 9.194 mg/L PBTK NA 50% Human Human -DTXSID4021397 Css NA 58.28 mg/L PBTK NA 95% Human Human -DTXSID4021397 Clint NA 1.087 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021397 Fup NA 0.0258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021397 Vd NA 0.3427 L/kg 1compartment NA NA Rat Human -DTXSID4021397 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4021397 TK.Half.Life NA 15.19 hours 1compartment NA NA Rat Human -DTXSID4021397 Css NA 6.402 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021397 Css NA 36.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021397 Css NA 3.612 mg/L PBTK NA 50% Rat Human -DTXSID4021397 Css NA 19.86 mg/L PBTK NA 95% Rat Human +DTXSID4021393 TK.Half.Life NA 2.318 hours 1compartment NA NA Rat Human +DTXSID4021393 Css NA 0.0189 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021393 Css NA 0.1545 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021393 Css NA 0.01435 mg/L PBTK NA 50% Rat Human +DTXSID4021393 Css NA 0.0964 mg/L PBTK NA 95% Rat Human +DTXSID4021397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021397 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021397 Vd NA 0.3316 L/kg 1compartment NA NA Human Human +DTXSID4021397 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4021397 TK.Half.Life NA 3.569 hours 1compartment NA NA Human Human +DTXSID4021397 Css NA 1.836 mg/L 3compartmentss NA 50% Human Human +DTXSID4021397 Css NA 18.41 mg/L 3compartmentss NA 95% Human Human +DTXSID4021397 Css NA 1.088 mg/L PBTK NA 50% Human Human +DTXSID4021397 Css NA 10.72 mg/L PBTK NA 95% Human Human +DTXSID4021397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021397 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021397 Vd NA 0.2814 L/kg 1compartment NA NA Rat Human +DTXSID4021397 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4021397 TK.Half.Life NA 1.987 hours 1compartment NA NA Rat Human +DTXSID4021397 Css NA 0.2415 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021397 Css NA 1.889 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021397 Css NA 0.1387 mg/L PBTK NA 50% Rat Human +DTXSID4021397 Css NA 1.064 mg/L PBTK NA 95% Rat Human DTXSID4021424 Clint NA 0.009568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021424 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021424 Vd NA 0.7979 L/kg 1compartment NA NA Human Human DTXSID4021424 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4021424 TK.Half.Life NA 5.082 hours 1compartment NA NA Human Human -DTXSID4021424 Css NA 0.8108 mg/L 3compartmentss NA 50% Human Human -DTXSID4021424 Css NA 5.473 mg/L 3compartmentss NA 95% Human Human -DTXSID4021424 Css NA 0.6822 mg/L PBTK NA 50% Human Human -DTXSID4021424 Css NA 3.613 mg/L PBTK NA 95% Human Human +DTXSID4021424 Css NA 0.6848 mg/L 3compartmentss NA 50% Human Human +DTXSID4021424 Css NA 4.444 mg/L 3compartmentss NA 95% Human Human +DTXSID4021424 Css NA 0.5788 mg/L PBTK NA 50% Human Human +DTXSID4021424 Css NA 2.98 mg/L PBTK NA 95% Human Human DTXSID4021424 Clint NA 0.009568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021424 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021424 Vd NA 0.8345 L/kg 1compartment NA NA Rat Human DTXSID4021424 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4021424 TK.Half.Life NA 1.826 hours 1compartment NA NA Rat Human -DTXSID4021424 Css NA 0.2065 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021424 Css NA 1.285 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021424 Css NA 0.171 mg/L PBTK NA 50% Rat Human -DTXSID4021424 Css NA 0.7757 mg/L PBTK NA 95% Rat Human +DTXSID4021424 Css NA 0.01249 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021424 Css NA 0.1011 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021424 Css NA 0.01028 mg/L PBTK NA 50% Rat Human +DTXSID4021424 Css NA 0.06738 mg/L PBTK NA 95% Rat Human DTXSID4021426 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021426 Fup NA 0.8439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021426 Vd NA 0.6546 L/kg 1compartment NA NA Human Human DTXSID4021426 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4021426 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human -DTXSID4021426 Css NA 0.9834 mg/L 3compartmentss NA 50% Human Human -DTXSID4021426 Css NA 5.652 mg/L 3compartmentss NA 95% Human Human -DTXSID4021426 Css NA 0.7907 mg/L PBTK NA 50% Human Human -DTXSID4021426 Css NA 3.624 mg/L PBTK NA 95% Human Human +DTXSID4021426 Css NA 0.9398 mg/L 3compartmentss NA 50% Human Human +DTXSID4021426 Css NA 5.514 mg/L 3compartmentss NA 95% Human Human +DTXSID4021426 Css NA 0.7578 mg/L PBTK NA 50% Human Human +DTXSID4021426 Css NA 3.498 mg/L PBTK NA 95% Human Human DTXSID4021426 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021426 Fup NA 0.8439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021426 Vd NA 0.6957 L/kg 1compartment NA NA Rat Human DTXSID4021426 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4021426 TK.Half.Life NA 1.818 hours 1compartment NA NA Rat Human -DTXSID4021426 Css NA 0.251 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021426 Css NA 1.443 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021426 Css NA 0.1958 mg/L PBTK NA 50% Rat Human -DTXSID4021426 Css NA 0.8585 mg/L PBTK NA 95% Rat Human +DTXSID4021426 Css NA 0.05084 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021426 Css NA 0.2865 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021426 Css NA 0.04162 mg/L PBTK NA 50% Rat Human +DTXSID4021426 Css NA 0.1783 mg/L PBTK NA 95% Rat Human DTXSID40214326 Clint 0.0066 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.105.0042595 NA Human Human DTXSID40214326 Fup 0.017 NA NA https://doi.org/10.1124/dmd.105.0042595 NA Human Human DTXSID40214326 Vd NA 0.2423 L/kg 1compartment NA NA Human Human DTXSID40214326 Days.Css NA 20 Days PBTK NA NA Human Human DTXSID40214326 TK.Half.Life NA 91.32 hours 1compartment NA NA Human Human -DTXSID40214326 Css NA 54.66 mg/L 3compartmentss NA 50% Human Human -DTXSID40214326 Css NA 385.6 mg/L 3compartmentss NA 95% Human Human -DTXSID40214326 Css NA 38.03 mg/L PBTK NA 50% Human Human -DTXSID40214326 Css NA 232.2 mg/L PBTK NA 95% Human Human +DTXSID40214326 Css NA 53.23 mg/L 3compartmentss NA 50% Human Human +DTXSID40214326 Css NA 325.5 mg/L 3compartmentss NA 95% Human Human +DTXSID40214326 Css NA 37.19 mg/L PBTK NA 50% Human Human +DTXSID40214326 Css NA 227.3 mg/L PBTK NA 95% Human Human DTXSID40214326 Clint 0.0066 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.105.0042595 NA Rat Human DTXSID40214326 Fup 0.017 NA NA https://doi.org/10.1124/dmd.105.0042595 NA Rat Human DTXSID40214326 Vd NA 0.2296 L/kg 1compartment NA NA Rat Human -DTXSID40214326 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID40214326 Days.Css NA 4 Days PBTK NA NA Rat Human DTXSID40214326 TK.Half.Life NA 29.63 hours 1compartment NA NA Rat Human -DTXSID40214326 Css NA 15.64 mg/L 3compartmentss NA 50% Rat Human -DTXSID40214326 Css NA 101.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID40214326 Css NA 10.17 mg/L PBTK NA 50% Rat Human -DTXSID40214326 Css NA 56.83 mg/L PBTK NA 95% Rat Human -DTXSID4021478 Clint NA 10.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021478 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021478 Vd NA 1.976 L/kg 1compartment NA NA Human Human -DTXSID4021478 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4021478 TK.Half.Life NA 27.69 hours 1compartment NA NA Human Human -DTXSID4021478 Css NA 2.16 mg/L 3compartmentss NA 50% Human Human -DTXSID4021478 Css NA 15.9 mg/L 3compartmentss NA 95% Human Human -DTXSID4021478 Css NA 1.394 mg/L PBTK NA 50% Human Human -DTXSID4021478 Css NA 9.879 mg/L PBTK NA 95% Human Human -DTXSID4021478 Clint NA 10.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021478 Fup NA 0.0312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021478 Vd NA 1.473 L/kg 1compartment NA NA Rat Human -DTXSID4021478 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4021478 TK.Half.Life NA 8.901 hours 1compartment NA NA Rat Human -DTXSID4021478 Css NA 1.191 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021478 Css NA 6.701 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021478 Css NA 0.7302 mg/L PBTK NA 50% Rat Human -DTXSID4021478 Css NA 3.883 mg/L PBTK NA 95% Rat Human -DTXSID4021559 Clint NA 4.522 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021559 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021559 Vd NA 2.412 L/kg 1compartment NA NA Human Human -DTXSID4021559 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID4021559 TK.Half.Life NA 97.37 hours 1compartment NA NA Human Human -DTXSID4021559 Css NA 6.04 mg/L 3compartmentss NA 50% Human Human -DTXSID4021559 Css NA 37.21 mg/L 3compartmentss NA 95% Human Human -DTXSID4021559 Css NA 4.011 mg/L PBTK NA 50% Human Human -DTXSID4021559 Css NA 23.47 mg/L PBTK NA 95% Human Human -DTXSID4021559 Clint NA 4.522 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021559 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021559 Vd NA 1.799 L/kg 1compartment NA NA Rat Human -DTXSID4021559 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID4021559 TK.Half.Life NA 23.89 hours 1compartment NA NA Rat Human -DTXSID4021559 Css NA 3.197 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021559 Css NA 15.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021559 Css NA 2.005 mg/L PBTK NA 50% Rat Human -DTXSID4021559 Css NA 8.834 mg/L PBTK NA 95% Rat Human +DTXSID40214326 Css NA 3.241 mg/L 3compartmentss NA 50% Rat Human +DTXSID40214326 Css NA 18.32 mg/L 3compartmentss NA 95% Rat Human +DTXSID40214326 Css NA 2.345 mg/L PBTK NA 50% Rat Human +DTXSID40214326 Css NA 13.25 mg/L PBTK NA 95% Rat Human +DTXSID4021472 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021472 Fup 0.756 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021472 Vd NA 0.7741 L/kg 1compartment NA NA Human Human +DTXSID4021472 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4021472 TK.Half.Life NA 6.652 hours 1compartment NA NA Human Human +DTXSID4021472 Css NA 0.8608 mg/L 3compartmentss NA 50% Human Human +DTXSID4021472 Css NA 5.619 mg/L 3compartmentss NA 95% Human Human +DTXSID4021472 Css NA 0.7176 mg/L PBTK NA 50% Human Human +DTXSID4021472 Css NA 3.616 mg/L PBTK NA 95% Human Human +DTXSID4021472 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021472 Fup 0.756 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021472 Vd NA 0.7878 L/kg 1compartment NA NA Rat Human +DTXSID4021472 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4021472 TK.Half.Life NA 2.301 hours 1compartment NA NA Rat Human +DTXSID4021472 Css NA 0.01647 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021472 Css NA 0.1278 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021472 Css NA 0.0132 mg/L PBTK NA 50% Rat Human +DTXSID4021472 Css NA 0.08348 mg/L PBTK NA 95% Rat Human +DTXSID4021478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021478 Fup 0.0186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021478 Vd NA 2.617 L/kg 1compartment NA NA Human Human +DTXSID4021478 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4021478 TK.Half.Life NA 36.27 hours 1compartment NA NA Human Human +DTXSID4021478 Css NA 1.88 mg/L 3compartmentss NA 50% Human Human +DTXSID4021478 Css NA 13.41 mg/L 3compartmentss NA 95% Human Human +DTXSID4021478 Css NA 1.254 mg/L PBTK NA 50% Human Human +DTXSID4021478 Css NA 8.595 mg/L PBTK NA 95% Human Human +DTXSID4021478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021478 Fup 0.0186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021478 Vd NA 1.954 L/kg 1compartment NA NA Rat Human +DTXSID4021478 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4021478 TK.Half.Life NA 8.259 hours 1compartment NA NA Rat Human +DTXSID4021478 Css NA 0.2442 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021478 Css NA 1.422 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021478 Css NA 0.1599 mg/L PBTK NA 50% Rat Human +DTXSID4021478 Css NA 0.8974 mg/L PBTK NA 95% Rat Human +DTXSID4021559 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021559 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021559 Vd NA 1.787 L/kg 1compartment NA NA Human Human +DTXSID4021559 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4021559 TK.Half.Life NA 26.3 hours 1compartment NA NA Human Human +DTXSID4021559 Css NA 2.329 mg/L 3compartmentss NA 50% Human Human +DTXSID4021559 Css NA 20.27 mg/L 3compartmentss NA 95% Human Human +DTXSID4021559 Css NA 1.469 mg/L PBTK NA 50% Human Human +DTXSID4021559 Css NA 12.26 mg/L PBTK NA 95% Human Human +DTXSID4021559 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021559 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021559 Vd NA 1.32 L/kg 1compartment NA NA Rat Human +DTXSID4021559 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4021559 TK.Half.Life NA 9.16 hours 1compartment NA NA Rat Human +DTXSID4021559 Css NA 0.2997 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021559 Css NA 2.169 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021559 Css NA 0.184 mg/L PBTK NA 50% Rat Human +DTXSID4021559 Css NA 1.272 mg/L PBTK NA 95% Rat Human DTXSID4021632 Clint NA 0.1703 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021632 Fup NA 0.5873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021632 Vd NA 0.572 L/kg 1compartment NA NA Human Human +DTXSID4021632 Vd NA 0.5805 L/kg 1compartment NA NA Human Human DTXSID4021632 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021632 TK.Half.Life NA 4.868 hours 1compartment NA NA Human Human -DTXSID4021632 Css NA 0.9667 mg/L 3compartmentss NA 50% Human Human -DTXSID4021632 Css NA 6.279 mg/L 3compartmentss NA 95% Human Human -DTXSID4021632 Css NA 0.75 mg/L PBTK NA 50% Human Human -DTXSID4021632 Css NA 3.942 mg/L PBTK NA 95% Human Human +DTXSID4021632 TK.Half.Life NA 4.948 hours 1compartment NA NA Human Human +DTXSID4021632 Css NA 0.812 mg/L 3compartmentss NA 50% Human Human +DTXSID4021632 Css NA 5.474 mg/L 3compartmentss NA 95% Human Human +DTXSID4021632 Css NA 0.6367 mg/L PBTK NA 50% Human Human +DTXSID4021632 Css NA 3.405 mg/L PBTK NA 95% Human Human DTXSID4021632 Clint NA 0.1703 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021632 Fup NA 0.5873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021632 Vd NA 0.5895 L/kg 1compartment NA NA Rat Human +DTXSID4021632 Vd NA 0.5968 L/kg 1compartment NA NA Rat Human DTXSID4021632 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021632 TK.Half.Life NA 1.935 hours 1compartment NA NA Rat Human -DTXSID4021632 Css NA 0.2954 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021632 Css NA 1.891 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021632 Css NA 0.2203 mg/L PBTK NA 50% Rat Human -DTXSID4021632 Css NA 1.1 mg/L PBTK NA 95% Rat Human +DTXSID4021632 TK.Half.Life NA 1.96 hours 1compartment NA NA Rat Human +DTXSID4021632 Css NA 0.01774 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021632 Css NA 0.154 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021632 Css NA 0.01346 mg/L PBTK NA 50% Rat Human +DTXSID4021632 Css NA 0.0971 mg/L PBTK NA 95% Rat Human DTXSID4021636 Clint NA 0.004202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021636 Fup NA 0.4431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021636 Vd NA 0.4259 L/kg 1compartment NA NA Human Human DTXSID4021636 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4021636 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human -DTXSID4021636 Css NA 1.676 mg/L 3compartmentss NA 50% Human Human -DTXSID4021636 Css NA 7.911 mg/L 3compartmentss NA 95% Human Human -DTXSID4021636 Css NA 1.203 mg/L PBTK NA 50% Human Human -DTXSID4021636 Css NA 4.889 mg/L PBTK NA 95% Human Human +DTXSID4021636 Css NA 1.427 mg/L 3compartmentss NA 50% Human Human +DTXSID4021636 Css NA 6.555 mg/L 3compartmentss NA 95% Human Human +DTXSID4021636 Css NA 1.024 mg/L PBTK NA 50% Human Human +DTXSID4021636 Css NA 4.133 mg/L PBTK NA 95% Human Human DTXSID4021636 Clint NA 0.004202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021636 Fup NA 0.4431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021636 Vd NA 0.4307 L/kg 1compartment NA NA Rat Human DTXSID4021636 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4021636 TK.Half.Life NA 2.135 hours 1compartment NA NA Rat Human -DTXSID4021636 Css NA 0.4637 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021636 Css NA 1.929 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021636 Css NA 0.316 mg/L PBTK NA 50% Rat Human -DTXSID4021636 Css NA 1.119 mg/L PBTK NA 95% Rat Human -DTXSID4021638 Clint NA 17.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021638 Fup NA 0.5735 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021638 Vd NA 0.8524 L/kg 1compartment NA NA Human Human -DTXSID4021638 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021638 TK.Half.Life NA 0.8427 hours 1compartment NA NA Human Human -DTXSID4021638 Css NA 0.0468 mg/L 3compartmentss NA 50% Human Human -DTXSID4021638 Css NA 0.4801 mg/L 3compartmentss NA 95% Human Human -DTXSID4021638 Css NA 0.03787 mg/L PBTK NA 50% Human Human -DTXSID4021638 Css NA 0.3283 mg/L PBTK NA 95% Human Human -DTXSID4021638 Clint NA 17.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021638 Fup NA 0.5735 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021638 Vd NA 0.8207 L/kg 1compartment NA NA Rat Human -DTXSID4021638 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021638 TK.Half.Life NA 0.4116 hours 1compartment NA NA Rat Human -DTXSID4021638 Css NA 0.02374 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021638 Css NA 0.216 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021638 Css NA 0.01874 mg/L PBTK NA 50% Rat Human -DTXSID4021638 Css NA 0.138 mg/L PBTK NA 95% Rat Human +DTXSID4021636 Css NA 0.02659 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021636 Css NA 0.1729 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021636 Css NA 0.01847 mg/L PBTK NA 50% Rat Human +DTXSID4021636 Css NA 0.107 mg/L PBTK NA 95% Rat Human DTXSID4021680 Clint NA 0.03749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021680 Fup NA 0.5426 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021680 Vd NA 1.336 L/kg 1compartment NA NA Human Human +DTXSID4021680 Vd NA 1.601 L/kg 1compartment NA NA Human Human DTXSID4021680 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4021680 TK.Half.Life NA 17.07 hours 1compartment NA NA Human Human -DTXSID4021680 Css NA 1.307 mg/L 3compartmentss NA 50% Human Human -DTXSID4021680 Css NA 7.617 mg/L 3compartmentss NA 95% Human Human -DTXSID4021680 Css NA 1.102 mg/L PBTK NA 50% Human Human -DTXSID4021680 Css NA 4.997 mg/L PBTK NA 95% Human Human +DTXSID4021680 TK.Half.Life NA 22.5 hours 1compartment NA NA Human Human +DTXSID4021680 Css NA 1.361 mg/L 3compartmentss NA 50% Human Human +DTXSID4021680 Css NA 7.673 mg/L 3compartmentss NA 95% Human Human +DTXSID4021680 Css NA 1.171 mg/L PBTK NA 50% Human Human +DTXSID4021680 Css NA 5.119 mg/L PBTK NA 95% Human Human DTXSID4021680 Clint NA 0.03749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021680 Fup NA 0.5426 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021680 Vd NA 1.163 L/kg 1compartment NA NA Rat Human +DTXSID4021680 Vd NA 1.349 L/kg 1compartment NA NA Rat Human DTXSID4021680 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021680 TK.Half.Life NA 4.738 hours 1compartment NA NA Rat Human -DTXSID4021680 Css NA 0.3604 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021680 Css NA 1.946 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021680 Css NA 0.2948 mg/L PBTK NA 50% Rat Human -DTXSID4021680 Css NA 1.186 mg/L PBTK NA 95% Rat Human -DTXSID4021684 Clint NA 3.232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021684 Fup NA 0.0236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021684 Vd NA 0.9076 L/kg 1compartment NA NA Human Human -DTXSID4021684 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID4021684 TK.Half.Life NA 37.67 hours 1compartment NA NA Human Human -DTXSID4021684 Css NA 7.018 mg/L 3compartmentss NA 50% Human Human -DTXSID4021684 Css NA 53.74 mg/L 3compartmentss NA 95% Human Human -DTXSID4021684 Css NA 4.424 mg/L PBTK NA 50% Human Human -DTXSID4021684 Css NA 31.57 mg/L PBTK NA 95% Human Human -DTXSID4021684 Clint NA 3.232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021684 Fup NA 0.0236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021684 Vd NA 0.6966 L/kg 1compartment NA NA Rat Human -DTXSID4021684 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4021684 TK.Half.Life NA 16.12 hours 1compartment NA NA Rat Human -DTXSID4021684 Css NA 3.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021684 Css NA 22.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021684 Css NA 2.119 mg/L PBTK NA 50% Rat Human -DTXSID4021684 Css NA 12.36 mg/L PBTK NA 95% Rat Human +DTXSID4021680 TK.Half.Life NA 5.635 hours 1compartment NA NA Rat Human +DTXSID4021680 Css NA 0.08738 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021680 Css NA 0.4646 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021680 Css NA 0.07489 mg/L PBTK NA 50% Rat Human +DTXSID4021680 Css NA 0.2949 mg/L PBTK NA 95% Rat Human +DTXSID4021684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021684 Fup 0.0331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021684 Vd NA 0.9721 L/kg 1compartment NA NA Human Human +DTXSID4021684 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4021684 TK.Half.Life NA 5.733 hours 1compartment NA NA Human Human +DTXSID4021684 Css NA 0.8674 mg/L 3compartmentss NA 50% Human Human +DTXSID4021684 Css NA 8.035 mg/L 3compartmentss NA 95% Human Human +DTXSID4021684 Css NA 0.5518 mg/L PBTK NA 50% Human Human +DTXSID4021684 Css NA 4.856 mg/L PBTK NA 95% Human Human +DTXSID4021684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021684 Fup 0.0331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021684 Vd NA 0.7519 L/kg 1compartment NA NA Rat Human +DTXSID4021684 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4021684 TK.Half.Life NA 2.618 hours 1compartment NA NA Rat Human +DTXSID4021684 Css NA 0.1136 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021684 Css NA 0.8007 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021684 Css NA 0.07093 mg/L PBTK NA 50% Rat Human +DTXSID4021684 Css NA 0.4697 mg/L PBTK NA 95% Rat Human +DTXSID4021715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021715 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021715 Vd NA 0.9477 L/kg 1compartment NA NA Human Human +DTXSID4021715 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4021715 TK.Half.Life NA 2.381 hours 1compartment NA NA Human Human +DTXSID4021715 Css NA 0.2642 mg/L 3compartmentss NA 50% Human Human +DTXSID4021715 Css NA 2.052 mg/L 3compartmentss NA 95% Human Human +DTXSID4021715 Css NA 0.1716 mg/L PBTK NA 50% Human Human +DTXSID4021715 Css NA 1.26 mg/L PBTK NA 95% Human Human +DTXSID4021715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021715 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021715 Vd NA 0.7529 L/kg 1compartment NA NA Rat Human +DTXSID4021715 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4021715 TK.Half.Life NA 1.056 hours 1compartment NA NA Rat Human +DTXSID4021715 Css NA 0.03422 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021715 Css NA 0.2153 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021715 Css NA 0.02159 mg/L PBTK NA 50% Rat Human +DTXSID4021715 Css NA 0.1293 mg/L PBTK NA 95% Rat Human DTXSID4021717 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4021717 Fup 0.0723 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4021717 Vd NA 1.796 L/kg 1compartment NA NA Human Human DTXSID4021717 Days.Css NA 59 Days PBTK NA NA Human Human DTXSID4021717 TK.Half.Life NA 264.3 hours 1compartment NA NA Human Human -DTXSID4021717 Css NA 17.8 mg/L 3compartmentss NA 50% Human Human -DTXSID4021717 Css NA 57.76 mg/L 3compartmentss NA 95% Human Human -DTXSID4021717 Css NA 11.9 mg/L PBTK NA 50% Human Human -DTXSID4021717 Css NA 35.82 mg/L PBTK NA 95% Human Human +DTXSID4021717 Css NA 17.23 mg/L 3compartmentss NA 50% Human Human +DTXSID4021717 Css NA 56.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4021717 Css NA 11.55 mg/L PBTK NA 50% Human Human +DTXSID4021717 Css NA 35.03 mg/L PBTK NA 95% Human Human DTXSID4021717 Clint 200.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4021717 Fup 0.151 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4021717 Vd NA 1.744 L/kg 1compartment NA NA Rat Rat DTXSID4021717 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID4021717 TK.Half.Life NA 0.7886 hours 1compartment NA NA Rat Rat -DTXSID4021717 Css NA 0.01765 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4021717 Css NA 0.1014 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4021717 Css NA 0.01186 mg/L PBTK NA 50% Rat Rat -DTXSID4021717 Css NA 0.06502 mg/L PBTK NA 95% Rat Rat +DTXSID4021717 Css NA 0.003734 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4021717 Css NA 0.02528 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4021717 Css NA 0.002604 mg/L PBTK NA 50% Rat Rat +DTXSID4021717 Css NA 0.01696 mg/L PBTK NA 95% Rat Rat DTXSID4021761 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4021761 Fup NA 0.8579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021761 Vd NA 1.306 L/kg 1compartment NA NA Human Human +DTXSID4021761 Vd NA 1.252 L/kg 1compartment NA NA Human Human DTXSID4021761 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021761 TK.Half.Life NA 9.849 hours 1compartment NA NA Human Human -DTXSID4021761 Css NA 0.833 mg/L 3compartmentss NA 50% Human Human -DTXSID4021761 Css NA 5.511 mg/L 3compartmentss NA 95% Human Human -DTXSID4021761 Css NA 0.7754 mg/L PBTK NA 50% Human Human -DTXSID4021761 Css NA 3.66 mg/L PBTK NA 95% Human Human +DTXSID4021761 TK.Half.Life NA 9.442 hours 1compartment NA NA Human Human +DTXSID4021761 Css NA 0.7282 mg/L 3compartmentss NA 50% Human Human +DTXSID4021761 Css NA 5.062 mg/L 3compartmentss NA 95% Human Human +DTXSID4021761 Css NA 0.6693 mg/L PBTK NA 50% Human Human +DTXSID4021761 Css NA 3.342 mg/L PBTK NA 95% Human Human DTXSID4021761 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4021761 Fup NA 0.8579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021761 Vd NA 1.334 L/kg 1compartment NA NA Rat Human +DTXSID4021761 Vd NA 1.283 L/kg 1compartment NA NA Rat Human DTXSID4021761 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021761 TK.Half.Life NA 3.428 hours 1compartment NA NA Rat Human -DTXSID4021761 Css NA 0.211 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021761 Css NA 1.392 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021761 Css NA 0.1931 mg/L PBTK NA 50% Rat Human -DTXSID4021761 Css NA 0.868 mg/L PBTK NA 95% Rat Human -DTXSID4021842 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021842 Fup NA 0.8156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021842 Vd NA 0.8004 L/kg 1compartment NA NA Human Human +DTXSID4021761 TK.Half.Life NA 3.298 hours 1compartment NA NA Rat Human +DTXSID4021761 Css NA 0.01346 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021761 Css NA 0.1062 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021761 Css NA 0.01194 mg/L PBTK NA 50% Rat Human +DTXSID4021761 Css NA 0.07455 mg/L PBTK NA 95% Rat Human +DTXSID4021769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021769 Fup 0.0329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021769 Vd NA 2.435 L/kg 1compartment NA NA Human Human +DTXSID4021769 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4021769 TK.Half.Life NA 21.67 hours 1compartment NA NA Human Human +DTXSID4021769 Css NA 1.206 mg/L 3compartmentss NA 50% Human Human +DTXSID4021769 Css NA 8.45 mg/L 3compartmentss NA 95% Human Human +DTXSID4021769 Css NA 0.8028 mg/L PBTK NA 50% Human Human +DTXSID4021769 Css NA 5.394 mg/L PBTK NA 95% Human Human +DTXSID4021769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021769 Fup 0.0329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021769 Vd NA 1.82 L/kg 1compartment NA NA Rat Human +DTXSID4021769 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4021769 TK.Half.Life NA 5.649 hours 1compartment NA NA Rat Human +DTXSID4021769 Css NA 0.1554 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021769 Css NA 0.9248 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021769 Css NA 0.1013 mg/L PBTK NA 50% Rat Human +DTXSID4021769 Css NA 0.582 mg/L PBTK NA 95% Rat Human +DTXSID4021842 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021842 Fup 0.635 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021842 Vd NA 0.6918 L/kg 1compartment NA NA Human Human DTXSID4021842 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021842 TK.Half.Life NA 6.448 hours 1compartment NA NA Human Human -DTXSID4021842 Css NA 0.9954 mg/L 3compartmentss NA 50% Human Human -DTXSID4021842 Css NA 5.855 mg/L 3compartmentss NA 95% Human Human -DTXSID4021842 Css NA 0.8104 mg/L PBTK NA 50% Human Human -DTXSID4021842 Css NA 3.775 mg/L PBTK NA 95% Human Human -DTXSID4021842 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021842 Fup NA 0.8156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021842 Vd NA 0.7807 L/kg 1compartment NA NA Rat Human +DTXSID4021842 TK.Half.Life NA 7.133 hours 1compartment NA NA Human Human +DTXSID4021842 Css NA 1.18 mg/L 3compartmentss NA 50% Human Human +DTXSID4021842 Css NA 7.637 mg/L 3compartmentss NA 95% Human Human +DTXSID4021842 Css NA 0.9292 mg/L PBTK NA 50% Human Human +DTXSID4021842 Css NA 4.738 mg/L PBTK NA 95% Human Human +DTXSID4021842 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021842 Fup 0.635 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021842 Vd NA 0.6727 L/kg 1compartment NA NA Rat Human DTXSID4021842 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021842 TK.Half.Life NA 2.118 hours 1compartment NA NA Rat Human -DTXSID4021842 Css NA 0.2556 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021842 Css NA 1.486 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021842 Css NA 0.2023 mg/L PBTK NA 50% Rat Human -DTXSID4021842 Css NA 0.8879 mg/L PBTK NA 95% Rat Human +DTXSID4021842 TK.Half.Life NA 2.342 hours 1compartment NA NA Rat Human +DTXSID4021842 Css NA 0.0718 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021842 Css NA 0.4149 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021842 Css NA 0.05592 mg/L PBTK NA 50% Rat Human +DTXSID4021842 Css NA 0.2519 mg/L PBTK NA 95% Rat Human +DTXSID40218445 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40218445 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40218445 Vd NA 3.069 L/kg 1compartment NA NA Human Human +DTXSID40218445 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID40218445 TK.Half.Life NA 27.26 hours 1compartment NA NA Human Human +DTXSID40218445 Css NA 0.956 mg/L 3compartmentss NA 50% Human Human +DTXSID40218445 Css NA 6.126 mg/L 3compartmentss NA 95% Human Human +DTXSID40218445 Css NA 0.6728 mg/L PBTK NA 50% Human Human +DTXSID40218445 Css NA 4.29 mg/L PBTK NA 95% Human Human +DTXSID40218445 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40218445 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40218445 Vd NA 2.309 L/kg 1compartment NA NA Rat Human +DTXSID40218445 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID40218445 TK.Half.Life NA 4.327 hours 1compartment NA NA Rat Human +DTXSID40218445 Css NA 0.123 mg/L 3compartmentss NA 50% Rat Human +DTXSID40218445 Css NA 0.6243 mg/L 3compartmentss NA 95% Rat Human +DTXSID40218445 Css NA 0.08622 mg/L PBTK NA 50% Rat Human +DTXSID40218445 Css NA 0.4258 mg/L PBTK NA 95% Rat Human DTXSID4021848 Clint 13.12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4021848 Fup 0.1414 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID4021848 Vd NA 1.358 L/kg 1compartment NA NA Human Human +DTXSID4021848 Vd NA 1.322 L/kg 1compartment NA NA Human Human DTXSID4021848 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021848 TK.Half.Life NA 4.111 hours 1compartment NA NA Human Human -DTXSID4021848 Css NA 0.3261 mg/L 3compartmentss NA 50% Human Human -DTXSID4021848 Css NA 2.413 mg/L 3compartmentss NA 95% Human Human -DTXSID4021848 Css NA 0.2224 mg/L PBTK NA 50% Human Human -DTXSID4021848 Css NA 1.524 mg/L PBTK NA 95% Human Human +DTXSID4021848 TK.Half.Life NA 3.974 hours 1compartment NA NA Human Human +DTXSID4021848 Css NA 0.3181 mg/L 3compartmentss NA 50% Human Human +DTXSID4021848 Css NA 2.383 mg/L 3compartmentss NA 95% Human Human +DTXSID4021848 Css NA 0.2167 mg/L PBTK NA 50% Human Human +DTXSID4021848 Css NA 1.519 mg/L PBTK NA 95% Human Human DTXSID4021848 Clint 13.12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4021848 Fup 0.1414 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID4021848 Vd NA 1.067 L/kg 1compartment NA NA Rat Human +DTXSID4021848 Vd NA 1.04 L/kg 1compartment NA NA Rat Human DTXSID4021848 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021848 TK.Half.Life NA 1.696 hours 1compartment NA NA Rat Human -DTXSID4021848 Css NA 0.1815 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021848 Css NA 1.012 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021848 Css NA 0.117 mg/L PBTK NA 50% Rat Human -DTXSID4021848 Css NA 0.6008 mg/L PBTK NA 95% Rat Human -DTXSID4021892 Clint NA 1.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021892 Fup NA 0.9401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021892 Vd NA 1.6 L/kg 1compartment NA NA Human Human +DTXSID4021848 TK.Half.Life NA 1.653 hours 1compartment NA NA Rat Human +DTXSID4021848 Css NA 0.04024 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021848 Css NA 0.2278 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021848 Css NA 0.02693 mg/L PBTK NA 50% Rat Human +DTXSID4021848 Css NA 0.1397 mg/L PBTK NA 95% Rat Human +DTXSID40218506 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40218506 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40218506 Vd NA 7.201 L/kg 1compartment NA NA Human Human +DTXSID40218506 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID40218506 TK.Half.Life NA 69.49 hours 1compartment NA NA Human Human +DTXSID40218506 Css NA 0.4358 mg/L 3compartmentss NA 50% Human Human +DTXSID40218506 Css NA 5.119 mg/L 3compartmentss NA 95% Human Human +DTXSID40218506 Css NA 0.8816 mg/L PBTK NA 50% Human Human +DTXSID40218506 Css NA 4.686 mg/L PBTK NA 95% Human Human +DTXSID40218506 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40218506 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40218506 Vd NA 5.937 L/kg 1compartment NA NA Rat Human +DTXSID40218506 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID40218506 TK.Half.Life NA 25.8 hours 1compartment NA NA Rat Human +DTXSID40218506 Css NA 0.03675 mg/L 3compartmentss NA 50% Rat Human +DTXSID40218506 Css NA 0.2967 mg/L 3compartmentss NA 95% Rat Human +DTXSID40218506 Css NA 0.0668 mg/L PBTK NA 50% Rat Human +DTXSID40218506 Css NA 0.2615 mg/L PBTK NA 95% Rat Human +DTXSID4021892 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021892 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021892 Vd NA 1.067 L/kg 1compartment NA NA Human Human DTXSID4021892 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021892 TK.Half.Life NA 4.569 hours 1compartment NA NA Human Human -DTXSID4021892 Css NA 0.2728 mg/L 3compartmentss NA 50% Human Human -DTXSID4021892 Css NA 1.174 mg/L 3compartmentss NA 95% Human Human -DTXSID4021892 Css NA 0.2591 mg/L PBTK NA 50% Human Human -DTXSID4021892 Css NA 0.9251 mg/L PBTK NA 95% Human Human -DTXSID4021892 Clint NA 1.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021892 Fup NA 0.9401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021892 Vd NA 1.48 L/kg 1compartment NA NA Rat Human +DTXSID4021892 TK.Half.Life NA 1.07 hours 1compartment NA NA Human Human +DTXSID4021892 Css NA 0.03122 mg/L 3compartmentss NA 50% Human Human +DTXSID4021892 Css NA 0.3186 mg/L 3compartmentss NA 95% Human Human +DTXSID4021892 Css NA 0.02526 mg/L PBTK NA 50% Human Human +DTXSID4021892 Css NA 0.226 mg/L PBTK NA 95% Human Human +DTXSID4021892 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021892 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021892 Vd NA 0.9794 L/kg 1compartment NA NA Rat Human DTXSID4021892 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021892 TK.Half.Life NA 1.93 hours 1compartment NA NA Rat Human -DTXSID4021892 Css NA 0.1047 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021892 Css NA 0.3933 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021892 Css NA 0.0999 mg/L PBTK NA 50% Rat Human -DTXSID4021892 Css NA 0.2793 mg/L PBTK NA 95% Rat Human -DTXSID4021894 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021894 Fup NA 0.7894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021894 Vd NA 1.35 L/kg 1compartment NA NA Human Human -DTXSID4021894 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4021894 TK.Half.Life NA 12.15 hours 1compartment NA NA Human Human -DTXSID4021894 Css NA 0.9446 mg/L 3compartmentss NA 50% Human Human -DTXSID4021894 Css NA 6.081 mg/L 3compartmentss NA 95% Human Human -DTXSID4021894 Css NA 0.8579 mg/L PBTK NA 50% Human Human -DTXSID4021894 Css NA 4.1 mg/L PBTK NA 95% Human Human -DTXSID4021894 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021894 Fup NA 0.7894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021894 Vd NA 1.229 L/kg 1compartment NA NA Rat Human +DTXSID4021892 TK.Half.Life NA 0.4944 hours 1compartment NA NA Rat Human +DTXSID4021892 Css NA 0.001117 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021892 Css NA 0.01186 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021892 Css NA 0.000894 mg/L PBTK NA 50% Rat Human +DTXSID4021892 Css NA 0.008164 mg/L PBTK NA 95% Rat Human +DTXSID4021894 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021894 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021894 Vd NA 1.146 L/kg 1compartment NA NA Human Human +DTXSID4021894 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4021894 TK.Half.Life NA 1.02 hours 1compartment NA NA Human Human +DTXSID4021894 Css NA 0.02624 mg/L 3compartmentss NA 50% Human Human +DTXSID4021894 Css NA 0.2964 mg/L 3compartmentss NA 95% Human Human +DTXSID4021894 Css NA 0.0221 mg/L PBTK NA 50% Human Human +DTXSID4021894 Css NA 0.2062 mg/L PBTK NA 95% Human Human +DTXSID4021894 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021894 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021894 Vd NA 1.04 L/kg 1compartment NA NA Rat Human DTXSID4021894 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021894 TK.Half.Life NA 3.513 hours 1compartment NA NA Rat Human -DTXSID4021894 Css NA 0.2454 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021894 Css NA 1.526 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021894 Css NA 0.2173 mg/L PBTK NA 50% Rat Human -DTXSID4021894 Css NA 0.9454 mg/L PBTK NA 95% Rat Human -DTXSID4021921 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021921 Fup NA 0.9956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021921 Vd NA 0.8366 L/kg 1compartment NA NA Human Human +DTXSID4021894 TK.Half.Life NA 0.4548 hours 1compartment NA NA Rat Human +DTXSID4021894 Css NA 0.0009338 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021894 Css NA 0.01214 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021894 Css NA 0.000779 mg/L PBTK NA 50% Rat Human +DTXSID4021894 Css NA 0.008509 mg/L PBTK NA 95% Rat Human +DTXSID4021921 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021921 Fup 0.751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021921 Vd NA 0.6831 L/kg 1compartment NA NA Human Human DTXSID4021921 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021921 TK.Half.Life NA 5.449 hours 1compartment NA NA Human Human -DTXSID4021921 Css NA 0.8403 mg/L 3compartmentss NA 50% Human Human -DTXSID4021921 Css NA 5.068 mg/L 3compartmentss NA 95% Human Human -DTXSID4021921 Css NA 0.7167 mg/L PBTK NA 50% Human Human -DTXSID4021921 Css NA 3.315 mg/L PBTK NA 95% Human Human -DTXSID4021921 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021921 Fup NA 0.9956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021921 Vd NA 0.8644 L/kg 1compartment NA NA Rat Human +DTXSID4021921 TK.Half.Life NA 5.889 hours 1compartment NA NA Human Human +DTXSID4021921 Css NA 0.8926 mg/L 3compartmentss NA 50% Human Human +DTXSID4021921 Css NA 5.596 mg/L 3compartmentss NA 95% Human Human +DTXSID4021921 Css NA 0.7244 mg/L PBTK NA 50% Human Human +DTXSID4021921 Css NA 3.579 mg/L PBTK NA 95% Human Human +DTXSID4021921 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021921 Fup 0.751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021921 Vd NA 0.7094 L/kg 1compartment NA NA Rat Human DTXSID4021921 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021921 TK.Half.Life NA 1.915 hours 1compartment NA NA Rat Human -DTXSID4021921 Css NA 0.2154 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021921 Css NA 1.228 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021921 Css NA 0.1788 mg/L PBTK NA 50% Rat Human -DTXSID4021921 Css NA 0.7485 mg/L PBTK NA 95% Rat Human -DTXSID4021971 Clint NA 6.878 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021971 Fup NA 0.2655 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021971 Vd NA 1.865 L/kg 1compartment NA NA Human Human +DTXSID4021921 TK.Half.Life NA 2.083 hours 1compartment NA NA Rat Human +DTXSID4021921 Css NA 0.01679 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021921 Css NA 0.1375 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021921 Css NA 0.01303 mg/L PBTK NA 50% Rat Human +DTXSID4021921 Css NA 0.08616 mg/L PBTK NA 95% Rat Human +DTXSID4021925 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4021925 Fup NA 0.7741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4021925 Vd NA 0.7366 L/kg 1compartment NA NA Human Human +DTXSID4021925 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4021925 TK.Half.Life NA 6.167 hours 1compartment NA NA Human Human +DTXSID4021925 Css NA 0.86 mg/L 3compartmentss NA 50% Human Human +DTXSID4021925 Css NA 5.44 mg/L 3compartmentss NA 95% Human Human +DTXSID4021925 Css NA 0.7097 mg/L PBTK NA 50% Human Human +DTXSID4021925 Css NA 3.457 mg/L PBTK NA 95% Human Human +DTXSID4021925 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4021925 Fup NA 0.7741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4021925 Vd NA 0.7583 L/kg 1compartment NA NA Rat Human +DTXSID4021925 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4021925 TK.Half.Life NA 2.161 hours 1compartment NA NA Rat Human +DTXSID4021925 Css NA 0.01598 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021925 Css NA 0.1304 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021925 Css NA 0.01272 mg/L PBTK NA 50% Rat Human +DTXSID4021925 Css NA 0.08185 mg/L PBTK NA 95% Rat Human +DTXSID4021971 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021971 Fup 0.0992 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021971 Vd NA 1.185 L/kg 1compartment NA NA Human Human DTXSID4021971 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021971 TK.Half.Life NA 6.307 hours 1compartment NA NA Human Human -DTXSID4021971 Css NA 0.3261 mg/L 3compartmentss NA 50% Human Human -DTXSID4021971 Css NA 1.861 mg/L 3compartmentss NA 95% Human Human -DTXSID4021971 Css NA 0.2429 mg/L PBTK NA 50% Human Human -DTXSID4021971 Css NA 1.301 mg/L PBTK NA 95% Human Human -DTXSID4021971 Clint NA 6.878 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021971 Fup NA 0.2655 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021971 Vd NA 1.464 L/kg 1compartment NA NA Rat Human +DTXSID4021971 TK.Half.Life NA 3.203 hours 1compartment NA NA Human Human +DTXSID4021971 Css NA 0.2504 mg/L 3compartmentss NA 50% Human Human +DTXSID4021971 Css NA 2.069 mg/L 3compartmentss NA 95% Human Human +DTXSID4021971 Css NA 0.1634 mg/L PBTK NA 50% Human Human +DTXSID4021971 Css NA 1.282 mg/L PBTK NA 95% Human Human +DTXSID4021971 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021971 Fup 0.0992 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021971 Vd NA 0.9203 L/kg 1compartment NA NA Rat Human DTXSID4021971 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021971 TK.Half.Life NA 2.247 hours 1compartment NA NA Rat Human -DTXSID4021971 Css NA 0.1672 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021971 Css NA 0.6877 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021971 Css NA 0.1206 mg/L PBTK NA 50% Rat Human -DTXSID4021971 Css NA 0.4619 mg/L PBTK NA 95% Rat Human -DTXSID4021973 Clint NA 24.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021973 Fup NA 0.3472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021973 Vd NA 1.638 L/kg 1compartment NA NA Human Human +DTXSID4021971 TK.Half.Life NA 1.343 hours 1compartment NA NA Rat Human +DTXSID4021971 Css NA 0.01242 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021971 Css NA 0.1128 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021971 Css NA 0.007908 mg/L PBTK NA 50% Rat Human +DTXSID4021971 Css NA 0.06763 mg/L PBTK NA 95% Rat Human +DTXSID4021973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021973 Fup 0.0879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021973 Vd NA 0.8118 L/kg 1compartment NA NA Human Human DTXSID4021973 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021973 TK.Half.Life NA 2.001 hours 1compartment NA NA Human Human -DTXSID4021973 Css NA 0.0633 mg/L 3compartmentss NA 50% Human Human -DTXSID4021973 Css NA 0.4622 mg/L 3compartmentss NA 95% Human Human -DTXSID4021973 Css NA 0.04928 mg/L PBTK NA 50% Human Human -DTXSID4021973 Css NA 0.3236 mg/L PBTK NA 95% Human Human -DTXSID4021973 Clint NA 24.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021973 Fup NA 0.3472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021973 Vd NA 1.325 L/kg 1compartment NA NA Rat Human +DTXSID4021973 TK.Half.Life NA 2.298 hours 1compartment NA NA Human Human +DTXSID4021973 Css NA 0.3216 mg/L 3compartmentss NA 50% Human Human +DTXSID4021973 Css NA 2.512 mg/L 3compartmentss NA 95% Human Human +DTXSID4021973 Css NA 0.2048 mg/L PBTK NA 50% Human Human +DTXSID4021973 Css NA 1.529 mg/L PBTK NA 95% Human Human +DTXSID4021973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021973 Fup 0.0879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021973 Vd NA 0.6484 L/kg 1compartment NA NA Rat Human DTXSID4021973 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021973 TK.Half.Life NA 0.7685 hours 1compartment NA NA Rat Human -DTXSID4021973 Css NA 0.03441 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021973 Css NA 0.1814 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021973 Css NA 0.02584 mg/L PBTK NA 50% Rat Human -DTXSID4021973 Css NA 0.12 mg/L PBTK NA 95% Rat Human +DTXSID4021973 TK.Half.Life NA 1.055 hours 1compartment NA NA Rat Human +DTXSID4021973 Css NA 0.04218 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021973 Css NA 0.2607 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021973 Css NA 0.02613 mg/L PBTK NA 50% Rat Human +DTXSID4021973 Css NA 0.1542 mg/L PBTK NA 95% Rat Human DTXSID4021975 Clint 64.57 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4021975 Fup 0.003875 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4021975 Vd NA 0.6974 L/kg 1compartment NA NA Human Human DTXSID4021975 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4021975 TK.Half.Life NA 8.254 hours 1compartment NA NA Human Human -DTXSID4021975 Css NA 2.019 mg/L 3compartmentss NA 50% Human Human -DTXSID4021975 Css NA 16.86 mg/L 3compartmentss NA 95% Human Human -DTXSID4021975 Css NA 1.29 mg/L PBTK NA 50% Human Human -DTXSID4021975 Css NA 10.17 mg/L PBTK NA 95% Human Human +DTXSID4021975 Css NA 1.984 mg/L 3compartmentss NA 50% Human Human +DTXSID4021975 Css NA 16.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4021975 Css NA 1.276 mg/L PBTK NA 50% Human Human +DTXSID4021975 Css NA 10.42 mg/L PBTK NA 95% Human Human DTXSID4021975 Clint 38.58 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4021975 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID4021975 Css NA 1.466 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4021975 Css NA 12.47 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4021977 Clint NA 7.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021977 Fup NA 0.3151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021977 Vd NA 2.139 L/kg 1compartment NA NA Human Human +DTXSID4021975 Css NA 0.3076 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4021975 Css NA 2.507 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4021977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021977 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021977 Vd NA 1.804 L/kg 1compartment NA NA Human Human DTXSID4021977 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021977 TK.Half.Life NA 6.424 hours 1compartment NA NA Human Human -DTXSID4021977 Css NA 0.2742 mg/L 3compartmentss NA 50% Human Human -DTXSID4021977 Css NA 1.582 mg/L 3compartmentss NA 95% Human Human -DTXSID4021977 Css NA 0.2094 mg/L PBTK NA 50% Human Human -DTXSID4021977 Css NA 1.135 mg/L PBTK NA 95% Human Human -DTXSID4021977 Clint NA 7.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021977 Fup NA 0.3151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021977 Vd NA 1.672 L/kg 1compartment NA NA Rat Human +DTXSID4021977 TK.Half.Life NA 3.445 hours 1compartment NA NA Human Human +DTXSID4021977 Css NA 0.1392 mg/L 3compartmentss NA 50% Human Human +DTXSID4021977 Css NA 0.8584 mg/L 3compartmentss NA 95% Human Human +DTXSID4021977 Css NA 0.1004 mg/L PBTK NA 50% Human Human +DTXSID4021977 Css NA 0.5896 mg/L PBTK NA 95% Human Human +DTXSID4021977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021977 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021977 Vd NA 1.402 L/kg 1compartment NA NA Rat Human DTXSID4021977 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021977 TK.Half.Life NA 2.088 hours 1compartment NA NA Rat Human -DTXSID4021977 Css NA 0.141 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021977 Css NA 0.6145 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021977 Css NA 0.1045 mg/L PBTK NA 50% Rat Human -DTXSID4021977 Css NA 0.4138 mg/L PBTK NA 95% Rat Human -DTXSID4021979 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021979 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4021979 Vd NA 1.064 L/kg 1compartment NA NA Human Human +DTXSID4021977 TK.Half.Life NA 1.248 hours 1compartment NA NA Rat Human +DTXSID4021977 Css NA 0.01744 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021977 Css NA 0.08641 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021977 Css NA 0.01258 mg/L PBTK NA 50% Rat Human +DTXSID4021977 Css NA 0.06027 mg/L PBTK NA 95% Rat Human +DTXSID4021979 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021979 Fup 0.813 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4021979 Vd NA 0.9373 L/kg 1compartment NA NA Human Human DTXSID4021979 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4021979 TK.Half.Life NA 7.011 hours 1compartment NA NA Human Human -DTXSID4021979 Css NA 0.7778 mg/L 3compartmentss NA 50% Human Human -DTXSID4021979 Css NA 5.326 mg/L 3compartmentss NA 95% Human Human -DTXSID4021979 Css NA 0.7008 mg/L PBTK NA 50% Human Human -DTXSID4021979 Css NA 3.524 mg/L PBTK NA 95% Human Human -DTXSID4021979 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021979 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4021979 Vd NA 1.054 L/kg 1compartment NA NA Rat Human +DTXSID4021979 TK.Half.Life NA 7.57 hours 1compartment NA NA Human Human +DTXSID4021979 Css NA 0.8086 mg/L 3compartmentss NA 50% Human Human +DTXSID4021979 Css NA 5.017 mg/L 3compartmentss NA 95% Human Human +DTXSID4021979 Css NA 0.6987 mg/L PBTK NA 50% Human Human +DTXSID4021979 Css NA 3.277 mg/L PBTK NA 95% Human Human +DTXSID4021979 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021979 Fup 0.813 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4021979 Vd NA 0.927 L/kg 1compartment NA NA Rat Human DTXSID4021979 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4021979 TK.Half.Life NA 2.334 hours 1compartment NA NA Rat Human -DTXSID4021979 Css NA 0.1951 mg/L 3compartmentss NA 50% Rat Human -DTXSID4021979 Css NA 1.286 mg/L 3compartmentss NA 95% Rat Human -DTXSID4021979 Css NA 0.1733 mg/L PBTK NA 50% Rat Human -DTXSID4021979 Css NA 0.7928 mg/L PBTK NA 95% Rat Human +DTXSID4021979 TK.Half.Life NA 2.522 hours 1compartment NA NA Rat Human +DTXSID4021979 Css NA 0.01472 mg/L 3compartmentss NA 50% Rat Human +DTXSID4021979 Css NA 0.1165 mg/L 3compartmentss NA 95% Rat Human +DTXSID4021979 Css NA 0.0123 mg/L PBTK NA 50% Rat Human +DTXSID4021979 Css NA 0.07655 mg/L PBTK NA 95% Rat Human DTXSID4022020 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4022020 Fup 0.0852 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4022020 Vd NA 0.7769 L/kg 1compartment NA NA Human Human DTXSID4022020 Days.Css NA 12 Days PBTK NA NA Human Human DTXSID4022020 TK.Half.Life NA 63.71 hours 1compartment NA NA Human Human -DTXSID4022020 Css NA 12.61 mg/L 3compartmentss NA 50% Human Human -DTXSID4022020 Css NA 56.21 mg/L 3compartmentss NA 95% Human Human -DTXSID4022020 Css NA 7.96 mg/L PBTK NA 50% Human Human -DTXSID4022020 Css NA 33.18 mg/L PBTK NA 95% Human Human +DTXSID4022020 Css NA 12.3 mg/L 3compartmentss NA 50% Human Human +DTXSID4022020 Css NA 54.18 mg/L 3compartmentss NA 95% Human Human +DTXSID4022020 Css NA 7.778 mg/L PBTK NA 50% Human Human +DTXSID4022020 Css NA 32.27 mg/L PBTK NA 95% Human Human DTXSID4022020 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4022020 Fup 0.0852 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4022020 Vd NA 0.6223 L/kg 1compartment NA NA Rat Human DTXSID4022020 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID4022020 TK.Half.Life NA 16.41 hours 1compartment NA NA Rat Human -DTXSID4022020 Css NA 3.518 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022020 Css NA 13.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022020 Css NA 2.09 mg/L PBTK NA 50% Rat Human -DTXSID4022020 Css NA 7.322 mg/L PBTK NA 95% Rat Human -DTXSID4022107 Clint NA 0.9737 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022107 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022107 Vd NA 1.973 L/kg 1compartment NA NA Human Human -DTXSID4022107 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022107 TK.Half.Life NA 5.267 hours 1compartment NA NA Human Human -DTXSID4022107 Css NA 0.2672 mg/L 3compartmentss NA 50% Human Human -DTXSID4022107 Css NA 2.112 mg/L 3compartmentss NA 95% Human Human -DTXSID4022107 Css NA 0.2695 mg/L PBTK NA 50% Human Human -DTXSID4022107 Css NA 1.526 mg/L PBTK NA 95% Human Human -DTXSID4022107 Clint NA 0.9737 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022107 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022107 Vd NA 1.999 L/kg 1compartment NA NA Rat Human +DTXSID4022020 Css NA 0.8001 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022020 Css NA 2.952 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022020 Css NA 0.4924 mg/L PBTK NA 50% Rat Human +DTXSID4022020 Css NA 1.699 mg/L PBTK NA 95% Rat Human +DTXSID4022107 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022107 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022107 Vd NA 1.431 L/kg 1compartment NA NA Human Human +DTXSID4022107 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4022107 TK.Half.Life NA 15 hours 1compartment NA NA Human Human +DTXSID4022107 Css NA 0.9069 mg/L 3compartmentss NA 50% Human Human +DTXSID4022107 Css NA 6.79 mg/L 3compartmentss NA 95% Human Human +DTXSID4022107 Css NA 0.818 mg/L PBTK NA 50% Human Human +DTXSID4022107 Css NA 4.415 mg/L PBTK NA 95% Human Human +DTXSID4022107 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022107 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022107 Vd 1.4 1.443 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID4022107 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022107 TK.Half.Life NA 2.556 hours 1compartment NA NA Rat Human -DTXSID4022107 Css NA 0.09723 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022107 Css NA 0.7471 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022107 Css NA 0.09887 mg/L PBTK NA 50% Rat Human -DTXSID4022107 Css NA 0.4774 mg/L PBTK NA 95% Rat Human -DTXSID4022109 Clint NA 0.09952 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022109 Fup NA 0.1984 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022109 Vd NA 1.992 L/kg 1compartment NA NA Human Human -DTXSID4022109 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID4022109 TK.Half.Life NA 95.69 hours 1compartment NA NA Human Human -DTXSID4022109 Css NA 5.345 mg/L 3compartmentss NA 50% Human Human -DTXSID4022109 Css NA 16.54 mg/L 3compartmentss NA 95% Human Human -DTXSID4022109 Css NA 3.892 mg/L PBTK NA 50% Human Human -DTXSID4022109 Css NA 10.73 mg/L PBTK NA 95% Human Human -DTXSID4022109 Clint NA 0.09952 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022109 Fup NA 0.1984 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022109 Vd NA 1.537 L/kg 1compartment NA NA Rat Human -DTXSID4022109 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID4022109 TK.Half.Life NA 18.42 hours 1compartment NA NA Rat Human -DTXSID4022109 Css NA 1.617 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022109 Css NA 4.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022109 Css NA 1.124 mg/L PBTK NA 50% Rat Human -DTXSID4022109 Css NA 2.611 mg/L PBTK NA 95% Rat Human -DTXSID4022153 Clint NA 310.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022153 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022153 Vd NA 9751 L/kg 1compartment NA NA Human Human -DTXSID4022153 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4022153 TK.Half.Life NA 20070 hours 1compartment NA NA Human Human -DTXSID4022153 Css NA 9.454e-05 mg/L 3compartmentss NA 50% Human Human -DTXSID4022153 Css NA 0.0005608 mg/L 3compartmentss NA 95% Human Human -DTXSID4022153 Css NA 0.1694 mg/L PBTK NA 50% Human Human -DTXSID4022153 Css NA 0.9556 mg/L PBTK NA 95% Human Human -DTXSID4022153 Clint NA 310.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022153 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022153 Vd NA 9171 L/kg 1compartment NA NA Rat Human -DTXSID4022153 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID4022153 TK.Half.Life NA 3270 hours 1compartment NA NA Rat Human -DTXSID4022153 Css NA 4.781e-05 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022153 Css NA 0.0002118 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022153 Css NA 0.09214 mg/L PBTK NA 50% Rat Human -DTXSID4022153 Css NA 0.3961 mg/L PBTK NA 95% Rat Human +DTXSID4022107 TK.Half.Life 17 5.138 hours 1compartment National Toxicology Program NA Rat Human +DTXSID4022107 Css 0.75 0.01736 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID4022107 Css 0.75 0.1641 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID4022107 Css 0.75 0.01507 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID4022107 Css 0.75 0.1067 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID4022109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022109 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022109 Vd NA 2.099 L/kg 1compartment NA NA Human Human +DTXSID4022109 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4022109 TK.Half.Life NA 4.053 hours 1compartment NA NA Human Human +DTXSID4022109 Css NA 0.1416 mg/L 3compartmentss NA 50% Human Human +DTXSID4022109 Css NA 0.9196 mg/L 3compartmentss NA 95% Human Human +DTXSID4022109 Css NA 0.1036 mg/L PBTK NA 50% Human Human +DTXSID4022109 Css NA 0.635 mg/L PBTK NA 95% Human Human +DTXSID4022109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022109 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022109 Vd NA 1.623 L/kg 1compartment NA NA Rat Human +DTXSID4022109 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4022109 TK.Half.Life NA 1.35 hours 1compartment NA NA Rat Human +DTXSID4022109 Css NA 0.01769 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022109 Css NA 0.08986 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022109 Css NA 0.01294 mg/L PBTK NA 50% Rat Human +DTXSID4022109 Css NA 0.0618 mg/L PBTK NA 95% Rat Human +DTXSID4022151 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022151 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022151 Vd NA 1.018 L/kg 1compartment NA NA Human Human +DTXSID4022151 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4022151 TK.Half.Life NA 10.87 hours 1compartment NA NA Human Human +DTXSID4022151 Css NA 1.734 mg/L 3compartmentss NA 50% Human Human +DTXSID4022151 Css NA 16.37 mg/L 3compartmentss NA 95% Human Human +DTXSID4022151 Css NA 1.054 mg/L PBTK NA 50% Human Human +DTXSID4022151 Css NA 9.831 mg/L PBTK NA 95% Human Human +DTXSID4022151 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022151 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022151 Vd NA 0.7545 L/kg 1compartment NA NA Rat Human +DTXSID4022151 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4022151 TK.Half.Life NA 4.751 hours 1compartment NA NA Rat Human +DTXSID4022151 Css NA 0.2296 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022151 Css NA 1.725 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022151 Css NA 0.136 mg/L PBTK NA 50% Rat Human +DTXSID4022151 Css NA 0.9821 mg/L PBTK NA 95% Rat Human DTXSID4022284 Clint NA 0.04913 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4022284 Fup NA 0.7641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4022284 Vd NA 1.855 L/kg 1compartment NA NA Human Human DTXSID4022284 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID4022284 TK.Half.Life NA 14.52 hours 1compartment NA NA Human Human -DTXSID4022284 Css NA 0.7533 mg/L 3compartmentss NA 50% Human Human -DTXSID4022284 Css NA 5.13 mg/L 3compartmentss NA 95% Human Human -DTXSID4022284 Css NA 0.7648 mg/L PBTK NA 50% Human Human -DTXSID4022284 Css NA 3.542 mg/L PBTK NA 95% Human Human +DTXSID4022284 Css NA 0.64 mg/L 3compartmentss NA 50% Human Human +DTXSID4022284 Css NA 4.476 mg/L 3compartmentss NA 95% Human Human +DTXSID4022284 Css NA 0.6498 mg/L PBTK NA 50% Human Human +DTXSID4022284 Css NA 3.048 mg/L PBTK NA 95% Human Human DTXSID4022284 Clint NA 0.04913 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4022284 Fup NA 0.7641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4022284 Vd NA 1.838 L/kg 1compartment NA NA Rat Human DTXSID4022284 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4022284 TK.Half.Life NA 5.1 hours 1compartment NA NA Rat Human -DTXSID4022284 Css NA 0.1995 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022284 Css NA 1.505 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022284 Css NA 0.2 mg/L PBTK NA 50% Rat Human -DTXSID4022284 Css NA 0.9582 mg/L PBTK NA 95% Rat Human +DTXSID4022284 Css NA 0.0126 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022284 Css NA 0.116 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022284 Css NA 0.01268 mg/L PBTK NA 50% Rat Human +DTXSID4022284 Css NA 0.08486 mg/L PBTK NA 95% Rat Human DTXSID4022288 Clint 79.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4022288 Fup 0.0252 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4022288 Vd NA 1.874 L/kg 1compartment NA NA Human Human DTXSID4022288 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4022288 TK.Half.Life NA 5.563 hours 1compartment NA NA Human Human -DTXSID4022288 Css NA 0.2844 mg/L 3compartmentss NA 50% Human Human -DTXSID4022288 Css NA 2.268 mg/L 3compartmentss NA 95% Human Human -DTXSID4022288 Css NA 0.1859 mg/L PBTK NA 50% Human Human -DTXSID4022288 Css NA 1.431 mg/L PBTK NA 95% Human Human +DTXSID4022288 Css NA 0.2707 mg/L 3compartmentss NA 50% Human Human +DTXSID4022288 Css NA 2.313 mg/L 3compartmentss NA 95% Human Human +DTXSID4022288 Css NA 0.1766 mg/L PBTK NA 50% Human Human +DTXSID4022288 Css NA 1.433 mg/L PBTK NA 95% Human Human DTXSID4022288 Clint 79.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4022288 Fup 0.0252 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4022288 Vd NA 1.395 L/kg 1compartment NA NA Rat Human DTXSID4022288 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4022288 TK.Half.Life NA 1.891 hours 1compartment NA NA Rat Human -DTXSID4022288 Css NA 0.1616 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022288 Css NA 1.068 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022288 Css NA 0.09999 mg/L PBTK NA 50% Rat Human -DTXSID4022288 Css NA 0.6292 mg/L PBTK NA 95% Rat Human -DTXSID4022311 Clint NA 28.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022311 Fup NA 0.0497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022311 Vd NA 1.261 L/kg 1compartment NA NA Human Human +DTXSID4022288 Css NA 0.03618 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022288 Css NA 0.2382 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022288 Css NA 0.02315 mg/L PBTK NA 50% Rat Human +DTXSID4022288 Css NA 0.1474 mg/L PBTK NA 95% Rat Human +DTXSID4022311 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022311 Fup 0.0916 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022311 Vd NA 0.5402 L/kg 1compartment NA NA Human Human DTXSID4022311 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022311 TK.Half.Life NA 4.636 hours 1compartment NA NA Human Human -DTXSID4022311 Css NA 0.4884 mg/L 3compartmentss NA 50% Human Human -DTXSID4022311 Css NA 4.003 mg/L 3compartmentss NA 95% Human Human -DTXSID4022311 Css NA 0.3084 mg/L PBTK NA 50% Human Human -DTXSID4022311 Css NA 2.438 mg/L PBTK NA 95% Human Human -DTXSID4022311 Clint NA 28.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022311 Fup NA 0.0497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022311 Vd NA 0.9509 L/kg 1compartment NA NA Rat Human +DTXSID4022311 TK.Half.Life NA 3.727 hours 1compartment NA NA Human Human +DTXSID4022311 Css NA 1.013 mg/L 3compartmentss NA 50% Human Human +DTXSID4022311 Css NA 6.867 mg/L 3compartmentss NA 95% Human Human +DTXSID4022311 Css NA 0.6337 mg/L PBTK NA 50% Human Human +DTXSID4022311 Css NA 4.076 mg/L PBTK NA 95% Human Human +DTXSID4022311 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022311 Fup 0.0916 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022311 Vd NA 0.4575 L/kg 1compartment NA NA Rat Human DTXSID4022311 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022311 TK.Half.Life NA 1.889 hours 1compartment NA NA Rat Human -DTXSID4022311 Css NA 0.2723 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022311 Css NA 1.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022311 Css NA 0.1615 mg/L PBTK NA 50% Rat Human -DTXSID4022311 Css NA 0.9777 mg/L PBTK NA 95% Rat Human -DTXSID4022315 Clint NA 15.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022315 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022315 Vd NA 0.9311 L/kg 1compartment NA NA Human Human +DTXSID4022311 TK.Half.Life NA 1.899 hours 1compartment NA NA Rat Human +DTXSID4022311 Css NA 0.1251 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022311 Css NA 0.6367 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022311 Css NA 0.07562 mg/L PBTK NA 50% Rat Human +DTXSID4022311 Css NA 0.3656 mg/L PBTK NA 95% Rat Human +DTXSID4022313 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022313 Fup 0.00135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022313 Vd NA 4.544 L/kg 1compartment NA NA Human Human +DTXSID4022313 Days.Css NA 27 Days PBTK NA NA Human Human +DTXSID4022313 TK.Half.Life NA 149.1 hours 1compartment NA NA Human Human +DTXSID4022313 Css NA 3.378 mg/L 3compartmentss NA 50% Human Human +DTXSID4022313 Css NA 19.7 mg/L 3compartmentss NA 95% Human Human +DTXSID4022313 Css NA 2.63 mg/L PBTK NA 50% Human Human +DTXSID4022313 Css NA 15.11 mg/L PBTK NA 95% Human Human +DTXSID4022313 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022313 Fup 0.00135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022313 Vd NA 3.455 L/kg 1compartment NA NA Rat Human +DTXSID4022313 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID4022313 TK.Half.Life NA 25.1 hours 1compartment NA NA Rat Human +DTXSID4022313 Css NA 0.4364 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022313 Css NA 2.074 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022313 Css NA 0.3399 mg/L PBTK NA 50% Rat Human +DTXSID4022313 Css NA 1.67 mg/L PBTK NA 95% Rat Human +DTXSID4022315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022315 Fup 0.0809 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022315 Vd NA 1.8 L/kg 1compartment NA NA Human Human DTXSID4022315 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022315 TK.Half.Life NA 6.942 hours 1compartment NA NA Human Human -DTXSID4022315 Css NA 1.17 mg/L 3compartmentss NA 50% Human Human -DTXSID4022315 Css NA 8.724 mg/L 3compartmentss NA 95% Human Human -DTXSID4022315 Css NA 0.7186 mg/L PBTK NA 50% Human Human -DTXSID4022315 Css NA 5.179 mg/L PBTK NA 95% Human Human -DTXSID4022315 Clint NA 15.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022315 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022315 Vd NA 0.701 L/kg 1compartment NA NA Rat Human +DTXSID4022315 TK.Half.Life NA 6.502 hours 1compartment NA NA Human Human +DTXSID4022315 Css NA 0.4222 mg/L 3compartmentss NA 50% Human Human +DTXSID4022315 Css NA 3.04 mg/L 3compartmentss NA 95% Human Human +DTXSID4022315 Css NA 0.2792 mg/L PBTK NA 50% Human Human +DTXSID4022315 Css NA 1.948 mg/L PBTK NA 95% Human Human +DTXSID4022315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022315 Fup 0.0809 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022315 Vd NA 1.355 L/kg 1compartment NA NA Rat Human DTXSID4022315 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022315 TK.Half.Life NA 3.079 hours 1compartment NA NA Rat Human -DTXSID4022315 Css NA 0.6662 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022315 Css NA 3.627 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022315 Css NA 0.3831 mg/L PBTK NA 50% Rat Human -DTXSID4022315 Css NA 2.039 mg/L PBTK NA 95% Rat Human +DTXSID4022315 TK.Half.Life NA 2.276 hours 1compartment NA NA Rat Human +DTXSID4022315 Css NA 0.05447 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022315 Css NA 0.3072 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022315 Css NA 0.03543 mg/L PBTK NA 50% Rat Human +DTXSID4022315 Css NA 0.1905 mg/L PBTK NA 95% Rat Human +DTXSID4022319 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022319 Fup 0.0818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022319 Vd NA 1.196 L/kg 1compartment NA NA Human Human +DTXSID4022319 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4022319 TK.Half.Life NA 9.826 hours 1compartment NA NA Human Human +DTXSID4022319 Css NA 1.168 mg/L 3compartmentss NA 50% Human Human +DTXSID4022319 Css NA 8.005 mg/L 3compartmentss NA 95% Human Human +DTXSID4022319 Css NA 0.7499 mg/L PBTK NA 50% Human Human +DTXSID4022319 Css NA 4.889 mg/L PBTK NA 95% Human Human +DTXSID4022319 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022319 Fup 0.0818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022319 Vd NA 0.9193 L/kg 1compartment NA NA Rat Human +DTXSID4022319 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4022319 TK.Half.Life NA 4.087 hours 1compartment NA NA Rat Human +DTXSID4022319 Css NA 0.1456 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022319 Css NA 0.7004 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022319 Css NA 0.09152 mg/L PBTK NA 50% Rat Human +DTXSID4022319 Css NA 0.4145 mg/L PBTK NA 95% Rat Human DTXSID4022361 Clint 18.34 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4022361 Fup 0.5936 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4022361 Vd NA 2.958 L/kg 1compartment NA NA Human Human DTXSID4022361 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4022361 TK.Half.Life NA 7.134 hours 1compartment NA NA Human Human -DTXSID4022361 Css NA 0.2032 mg/L 3compartmentss NA 50% Human Human -DTXSID4022361 Css NA 1.296 mg/L 3compartmentss NA 95% Human Human -DTXSID4022361 Css NA 0.1552 mg/L PBTK NA 50% Human Human -DTXSID4022361 Css NA 0.9403 mg/L PBTK NA 95% Human Human +DTXSID4022361 Css NA 0.1975 mg/L 3compartmentss NA 50% Human Human +DTXSID4022361 Css NA 1.321 mg/L 3compartmentss NA 95% Human Human +DTXSID4022361 Css NA 0.15 mg/L PBTK NA 50% Human Human +DTXSID4022361 Css NA 0.9415 mg/L PBTK NA 95% Human Human DTXSID4022361 Clint 18.34 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4022361 Fup 0.5936 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4022361 Vd NA 2.268 L/kg 1compartment NA NA Rat Human DTXSID4022361 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4022361 TK.Half.Life NA 1.588 hours 1compartment NA NA Rat Human -DTXSID4022361 Css NA 0.1109 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022361 Css NA 0.5376 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022361 Css NA 0.08161 mg/L PBTK NA 50% Rat Human -DTXSID4022361 Css NA 0.3748 mg/L PBTK NA 95% Rat Human +DTXSID4022361 Css NA 0.02475 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022361 Css NA 0.1273 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022361 Css NA 0.01895 mg/L PBTK NA 50% Rat Human +DTXSID4022361 Css NA 0.09249 mg/L PBTK NA 95% Rat Human DTXSID4022367 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4022367 Fup 0.0308 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4022367 Vd NA 2.883 L/kg 1compartment NA NA Human Human DTXSID4022367 Days.Css NA 203 Days PBTK NA NA Human Human DTXSID4022367 TK.Half.Life NA 789.2 hours 1compartment NA NA Human Human -DTXSID4022367 Css NA 11.22 mg/L 3compartmentss NA 50% Human Human -DTXSID4022367 Css NA 79.33 mg/L 3compartmentss NA 95% Human Human -DTXSID4022367 Css NA 17.9 mg/L PBTK NA 50% Human Human -DTXSID4022367 Css NA 74.13 mg/L PBTK NA 95% Human Human +DTXSID4022367 Css NA 11 mg/L 3compartmentss NA 50% Human Human +DTXSID4022367 Css NA 74.29 mg/L 3compartmentss NA 95% Human Human +DTXSID4022367 Css NA 17.56 mg/L PBTK NA 50% Human Human +DTXSID4022367 Css NA 70.55 mg/L PBTK NA 95% Human Human DTXSID4022367 Clint 61.6 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4022367 Fup 0.0442 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4022367 Vd NA 3.274 L/kg 1compartment NA NA Rat Rat DTXSID4022367 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID4022367 TK.Half.Life NA 3.119 hours 1compartment NA NA Rat Rat -DTXSID4022367 Css NA 0.05756 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4022367 Css NA 0.5594 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4022367 Css NA 0.0887 mg/L PBTK NA 50% Rat Rat -DTXSID4022367 Css NA 0.567 mg/L PBTK NA 95% Rat Rat -DTXSID4022369 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4022369 Fup 0.00264 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4022369 Vd NA 5540 L/kg 1compartment NA NA Human Human -DTXSID4022369 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID4022369 TK.Half.Life NA 2.31e+08 hours 1compartment NA NA Human Human -DTXSID4022369 Css NA 0.02192 mg/L 3compartmentss NA 50% Human Human -DTXSID4022369 Css NA 0.1239 mg/L 3compartmentss NA 95% Human Human -DTXSID4022369 Css NA 21.8 mg/L PBTK NA 50% Human Human -DTXSID4022369 Css NA 112.5 mg/L PBTK NA 95% Human Human -DTXSID4022369 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4022369 Fup 0.00264 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4022369 Vd NA 5188 L/kg 1compartment NA NA Rat Human -DTXSID4022369 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID4022369 TK.Half.Life NA 23900000 hours 1compartment NA NA Rat Human -DTXSID4022369 Css NA 0.01096 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022369 Css NA 0.04295 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022369 Css NA 11.69 mg/L PBTK NA 50% Rat Human -DTXSID4022369 Css NA 46.3 mg/L PBTK NA 95% Rat Human +DTXSID4022367 Css NA 0.01301 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4022367 Css NA 0.1345 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4022367 Css NA 0.02072 mg/L PBTK NA 50% Rat Rat +DTXSID4022367 Css NA 0.1403 mg/L PBTK NA 95% Rat Rat DTXSID4022442 Clint 35.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4022442 Fup 0.01823 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID4022442 Vd NA 1.863 L/kg 1compartment NA NA Human Human +DTXSID4022442 Vd NA 1.671 L/kg 1compartment NA NA Human Human DTXSID4022442 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022442 TK.Half.Life NA 12.6 hours 1compartment NA NA Human Human -DTXSID4022442 Css NA 0.9918 mg/L 3compartmentss NA 50% Human Human -DTXSID4022442 Css NA 8.785 mg/L 3compartmentss NA 95% Human Human -DTXSID4022442 Css NA 0.6324 mg/L PBTK NA 50% Human Human -DTXSID4022442 Css NA 5.38 mg/L PBTK NA 95% Human Human +DTXSID4022442 TK.Half.Life NA 10.92 hours 1compartment NA NA Human Human +DTXSID4022442 Css NA 0.949 mg/L 3compartmentss NA 50% Human Human +DTXSID4022442 Css NA 9.087 mg/L 3compartmentss NA 95% Human Human +DTXSID4022442 Css NA 0.5971 mg/L PBTK NA 50% Human Human +DTXSID4022442 Css NA 5.527 mg/L PBTK NA 95% Human Human DTXSID4022442 Clint 35.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4022442 Fup 0.01823 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID4022442 Vd NA 1.383 L/kg 1compartment NA NA Rat Human +DTXSID4022442 Vd NA 1.239 L/kg 1compartment NA NA Rat Human DTXSID4022442 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022442 TK.Half.Life NA 4.295 hours 1compartment NA NA Rat Human -DTXSID4022442 Css NA 0.5551 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022442 Css NA 4.017 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022442 Css NA 0.3317 mg/L PBTK NA 50% Rat Human -DTXSID4022442 Css NA 2.281 mg/L PBTK NA 95% Rat Human +DTXSID4022442 TK.Half.Life NA 3.979 hours 1compartment NA NA Rat Human +DTXSID4022442 Css NA 0.1237 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022442 Css NA 0.9228 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022442 Css NA 0.07599 mg/L PBTK NA 50% Rat Human +DTXSID4022442 Css NA 0.5409 mg/L PBTK NA 95% Rat Human DTXSID4022446 Clint 83.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4022446 Fup 0.041 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4022446 Vd NA 1.862 L/kg 1compartment NA NA Human Human +DTXSID4022446 Vd NA 1.458 L/kg 1compartment NA NA Human Human DTXSID4022446 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022446 TK.Half.Life NA 4.114 hours 1compartment NA NA Human Human -DTXSID4022446 Css NA 0.1787 mg/L 3compartmentss NA 50% Human Human -DTXSID4022446 Css NA 1.279 mg/L 3compartmentss NA 95% Human Human -DTXSID4022446 Css NA 0.1176 mg/L PBTK NA 50% Human Human -DTXSID4022446 Css NA 0.8108 mg/L PBTK NA 95% Human Human +DTXSID4022446 TK.Half.Life NA 3.026 hours 1compartment NA NA Human Human +DTXSID4022446 Css NA 0.1528 mg/L 3compartmentss NA 50% Human Human +DTXSID4022446 Css NA 1.223 mg/L 3compartmentss NA 95% Human Human +DTXSID4022446 Css NA 0.09878 mg/L PBTK NA 50% Human Human +DTXSID4022446 Css NA 0.756 mg/L PBTK NA 95% Human Human DTXSID4022446 Clint 89.7 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4022446 Fup 0.0378 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID4022446 Vd NA 1.35 L/kg 1compartment NA NA Rat Rat +DTXSID4022446 Vd NA 1.052 L/kg 1compartment NA NA Rat Rat DTXSID4022446 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4022446 TK.Half.Life NA 1.394 hours 1compartment NA NA Rat Rat -DTXSID4022446 Css NA 0.1266 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4022446 Css NA 0.8468 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4022446 Css NA 0.07674 mg/L PBTK NA 50% Rat Rat -DTXSID4022446 Css NA 0.4896 mg/L PBTK NA 95% Rat Rat +DTXSID4022446 TK.Half.Life NA 1.116 hours 1compartment NA NA Rat Rat +DTXSID4022446 Css NA 0.02699 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4022446 Css NA 0.209 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4022446 Css NA 0.01654 mg/L PBTK NA 50% Rat Rat +DTXSID4022446 Css NA 0.1229 mg/L PBTK NA 95% Rat Rat DTXSID4022448 Clint 35.37 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4022448 Fup 0.1773 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4022448 Vd NA 2.446 L/kg 1compartment NA NA Human Human DTXSID4022448 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4022448 TK.Half.Life NA 4.983 hours 1compartment NA NA Human Human -DTXSID4022448 Css NA 0.1589 mg/L 3compartmentss NA 50% Human Human -DTXSID4022448 Css NA 1.006 mg/L 3compartmentss NA 95% Human Human -DTXSID4022448 Css NA 0.1134 mg/L PBTK NA 50% Human Human -DTXSID4022448 Css NA 0.6856 mg/L PBTK NA 95% Human Human +DTXSID4022448 Css NA 0.1512 mg/L 3compartmentss NA 50% Human Human +DTXSID4022448 Css NA 0.9503 mg/L 3compartmentss NA 95% Human Human +DTXSID4022448 Css NA 0.1084 mg/L PBTK NA 50% Human Human +DTXSID4022448 Css NA 0.6548 mg/L PBTK NA 95% Human Human DTXSID4022448 Clint 35.37 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4022448 Fup 0.1773 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4022448 Vd NA 1.86 L/kg 1compartment NA NA Rat Human DTXSID4022448 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4022448 TK.Half.Life NA 1.446 hours 1compartment NA NA Rat Human -DTXSID4022448 Css NA 0.08637 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022448 Css NA 0.4431 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022448 Css NA 0.05959 mg/L PBTK NA 50% Rat Human -DTXSID4022448 Css NA 0.2933 mg/L PBTK NA 95% Rat Human -DTXSID4022521 Clint NA 137.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022521 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022521 Vd NA 510.6 L/kg 1compartment NA NA Human Human -DTXSID4022521 Days.Css NA 623 Days PBTK NA NA Human Human -DTXSID4022521 TK.Half.Life NA 2416 hours 1compartment NA NA Human Human -DTXSID4022521 Css NA 0.00524 mg/L 3compartmentss NA 50% Human Human -DTXSID4022521 Css NA 0.03227 mg/L 3compartmentss NA 95% Human Human -DTXSID4022521 Css NA 0.3962 mg/L PBTK NA 50% Human Human -DTXSID4022521 Css NA 2.174 mg/L PBTK NA 95% Human Human -DTXSID4022521 Clint NA 137.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022521 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022521 Vd NA 461.5 L/kg 1compartment NA NA Rat Human -DTXSID4022521 Days.Css NA 413 Days PBTK NA NA Rat Human -DTXSID4022521 TK.Half.Life NA 398.6 hours 1compartment NA NA Rat Human -DTXSID4022521 Css NA 0.002656 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022521 Css NA 0.01121 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022521 Css NA 0.2147 mg/L PBTK NA 50% Rat Human -DTXSID4022521 Css NA 0.9037 mg/L PBTK NA 95% Rat Human -DTXSID4022523 Clint NA 89.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022523 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022523 Vd NA 2.932 L/kg 1compartment NA NA Human Human -DTXSID4022523 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022523 TK.Half.Life NA 13.48 hours 1compartment NA NA Human Human -DTXSID4022523 Css NA 0.5121 mg/L 3compartmentss NA 50% Human Human -DTXSID4022523 Css NA 3.474 mg/L 3compartmentss NA 95% Human Human -DTXSID4022523 Css NA 0.3476 mg/L PBTK NA 50% Human Human -DTXSID4022523 Css NA 2.269 mg/L PBTK NA 95% Human Human -DTXSID4022523 Clint NA 89.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022523 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022523 Vd NA 2.195 L/kg 1compartment NA NA Rat Human +DTXSID4022448 Css NA 0.01922 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022448 Css NA 0.1027 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022448 Css NA 0.01375 mg/L PBTK NA 50% Rat Human +DTXSID4022448 Css NA 0.07136 mg/L PBTK NA 95% Rat Human +DTXSID4022523 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022523 Fup 0.032 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022523 Vd NA 2.966 L/kg 1compartment NA NA Human Human +DTXSID4022523 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4022523 TK.Half.Life NA 47.31 hours 1compartment NA NA Human Human +DTXSID4022523 Css NA 1.984 mg/L 3compartmentss NA 50% Human Human +DTXSID4022523 Css NA 12.75 mg/L 3compartmentss NA 95% Human Human +DTXSID4022523 Css NA 1.358 mg/L PBTK NA 50% Human Human +DTXSID4022523 Css NA 8.561 mg/L PBTK NA 95% Human Human +DTXSID4022523 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022523 Fup 0.032 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022523 Vd NA 2.221 L/kg 1compartment NA NA Rat Human DTXSID4022523 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022523 TK.Half.Life NA 1.317 hours 1compartment NA NA Rat Human -DTXSID4022523 Css NA 0.0831 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022523 Css NA 0.4563 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022523 Css NA 0.054 mg/L PBTK NA 50% Rat Human -DTXSID4022523 Css NA 0.289 mg/L PBTK NA 95% Rat Human -DTXSID4022525 Clint NA 34.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022525 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022525 Vd NA 2.358 L/kg 1compartment NA NA Human Human -DTXSID4022525 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4022525 TK.Half.Life NA 16.8 hours 1compartment NA NA Human Human -DTXSID4022525 Css NA 0.9767 mg/L 3compartmentss NA 50% Human Human -DTXSID4022525 Css NA 7.639 mg/L 3compartmentss NA 95% Human Human -DTXSID4022525 Css NA 0.6428 mg/L PBTK NA 50% Human Human -DTXSID4022525 Css NA 4.795 mg/L PBTK NA 95% Human Human -DTXSID4022525 Clint NA 34.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022525 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022525 Vd NA 1.757 L/kg 1compartment NA NA Rat Human +DTXSID4022523 TK.Half.Life NA 1.301 hours 1compartment NA NA Rat Human +DTXSID4022523 Css NA 0.01768 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022523 Css NA 0.108 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022523 Css NA 0.012 mg/L PBTK NA 50% Rat Human +DTXSID4022523 Css NA 0.07099 mg/L PBTK NA 95% Rat Human +DTXSID4022525 Clint 128 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID4022525 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022525 Vd NA 2.571 L/kg 1compartment NA NA Human Human +DTXSID4022525 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4022525 TK.Half.Life NA 5.924 hours 1compartment NA NA Human Human +DTXSID4022525 Css NA 0.2039 mg/L 3compartmentss NA 50% Human Human +DTXSID4022525 Css NA 1.419 mg/L 3compartmentss NA 95% Human Human +DTXSID4022525 Css NA 0.136 mg/L PBTK NA 50% Human Human +DTXSID4022525 Css NA 0.9138 mg/L PBTK NA 95% Human Human +DTXSID4022525 Clint 128 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human +DTXSID4022525 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022525 Vd NA 1.922 L/kg 1compartment NA NA Rat Human DTXSID4022525 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022525 TK.Half.Life NA 1.109 hours 1compartment NA NA Rat Human -DTXSID4022525 Css NA 0.0629 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022525 Css NA 0.4124 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022525 Css NA 0.0392 mg/L PBTK NA 50% Rat Human -DTXSID4022525 Css NA 0.2463 mg/L PBTK NA 95% Rat Human +DTXSID4022525 TK.Half.Life NA 1.078 hours 1compartment NA NA Rat Human +DTXSID4022525 Css NA 0.01137 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022525 Css NA 0.06889 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022525 Css NA 0.007514 mg/L PBTK NA 50% Rat Human +DTXSID4022525 Css NA 0.04453 mg/L PBTK NA 95% Rat Human DTXSID4022527 Clint 38 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4022527 Fup 0.07639 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID4022527 Vd NA 1.67 L/kg 1compartment NA NA Human Human +DTXSID4022527 Vd NA 1.657 L/kg 1compartment NA NA Human Human DTXSID4022527 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022527 TK.Half.Life NA 4.068 hours 1compartment NA NA Human Human -DTXSID4022527 Css NA 0.2552 mg/L 3compartmentss NA 50% Human Human -DTXSID4022527 Css NA 1.936 mg/L 3compartmentss NA 95% Human Human -DTXSID4022527 Css NA 0.1672 mg/L PBTK NA 50% Human Human -DTXSID4022527 Css NA 1.199 mg/L PBTK NA 95% Human Human +DTXSID4022527 TK.Half.Life NA 4.025 hours 1compartment NA NA Human Human +DTXSID4022527 Css NA 0.2446 mg/L 3compartmentss NA 50% Human Human +DTXSID4022527 Css NA 1.809 mg/L 3compartmentss NA 95% Human Human +DTXSID4022527 Css NA 0.1611 mg/L PBTK NA 50% Human Human +DTXSID4022527 Css NA 1.132 mg/L PBTK NA 95% Human Human DTXSID4022527 Clint 246 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4022527 Fup 0.0241 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID4022527 Vd NA 0.7305 L/kg 1compartment NA NA Rat Rat +DTXSID4022527 Vd NA 0.7234 L/kg 1compartment NA NA Rat Rat DTXSID4022527 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4022527 TK.Half.Life NA 0.5849 hours 1compartment NA NA Rat Rat -DTXSID4022527 Css NA 0.0641 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4022527 Css NA 0.5365 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4022527 Css NA 0.03668 mg/L PBTK NA 50% Rat Rat -DTXSID4022527 Css NA 0.2955 mg/L PBTK NA 95% Rat Rat +DTXSID4022527 TK.Half.Life 1 0.58 hours 1compartment Gazin et al. (2013) NA Rat Rat +DTXSID4022527 Css NA 0.01428 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4022527 Css NA 0.1269 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4022527 Css NA 0.008438 mg/L PBTK NA 50% Rat Rat +DTXSID4022527 Css NA 0.07337 mg/L PBTK NA 95% Rat Rat DTXSID4022529 Clint 107.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4022529 Fup 0.07056 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4022529 Vd NA 0.5923 L/kg 1compartment NA NA Human Human DTXSID4022529 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4022529 TK.Half.Life NA 0.8285 hours 1compartment NA NA Human Human -DTXSID4022529 Css NA 0.08658 mg/L 3compartmentss NA 50% Human Human -DTXSID4022529 Css NA 0.677 mg/L 3compartmentss NA 95% Human Human -DTXSID4022529 Css NA 0.05333 mg/L PBTK NA 50% Human Human -DTXSID4022529 Css NA 0.4058 mg/L PBTK NA 95% Human Human +DTXSID4022529 Css NA 0.08047 mg/L 3compartmentss NA 50% Human Human +DTXSID4022529 Css NA 0.6548 mg/L 3compartmentss NA 95% Human Human +DTXSID4022529 Css NA 0.04984 mg/L PBTK NA 50% Human Human +DTXSID4022529 Css NA 0.39 mg/L PBTK NA 95% Human Human DTXSID4022529 Clint 86.2 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4022529 Fup 0.174 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4022529 Vd NA 0.7805 L/kg 1compartment NA NA Rat Rat DTXSID4022529 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID4022529 TK.Half.Life NA 0.4101 hours 1compartment NA NA Rat Rat -DTXSID4022529 Css NA 0.01906 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4022529 Css NA 0.1112 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4022529 Css NA 0.01243 mg/L PBTK NA 50% Rat Rat -DTXSID4022529 Css NA 0.06855 mg/L PBTK NA 95% Rat Rat -DTXSID4022571 Clint NA 4.525 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4022529 Css NA 0.004062 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4022529 Css NA 0.02487 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4022529 Css NA 0.00276 mg/L PBTK NA 50% Rat Rat +DTXSID4022529 Css NA 0.01611 mg/L PBTK NA 95% Rat Rat +DTXSID4022571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4022571 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4022571 Vd NA 3.056 L/kg 1compartment NA NA Human Human DTXSID4022571 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022571 TK.Half.Life NA 9.332 hours 1compartment NA NA Human Human -DTXSID4022571 Css NA 0.2362 mg/L 3compartmentss NA 50% Human Human -DTXSID4022571 Css NA 1.435 mg/L 3compartmentss NA 95% Human Human -DTXSID4022571 Css NA 0.2312 mg/L PBTK NA 50% Human Human -DTXSID4022571 Css NA 1.164 mg/L PBTK NA 95% Human Human -DTXSID4022571 Clint NA 4.525 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4022571 TK.Half.Life NA 3.42 hours 1compartment NA NA Human Human +DTXSID4022571 Css NA 0.052 mg/L 3compartmentss NA 50% Human Human +DTXSID4022571 Css NA 0.412 mg/L 3compartmentss NA 95% Human Human +DTXSID4022571 Css NA 0.05076 mg/L PBTK NA 50% Human Human +DTXSID4022571 Css NA 0.3452 mg/L PBTK NA 95% Human Human +DTXSID4022571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4022571 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4022571 Vd NA 2.788 L/kg 1compartment NA NA Rat Human DTXSID4022571 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022571 TK.Half.Life NA 3.862 hours 1compartment NA NA Rat Human -DTXSID4022571 Css NA 0.1152 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022571 Css NA 0.5248 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022571 Css NA 0.1108 mg/L PBTK NA 50% Rat Human -DTXSID4022571 Css NA 0.3995 mg/L PBTK NA 95% Rat Human -DTXSID4022573 Clint NA 3.879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4022571 TK.Half.Life NA 1.45 hours 1compartment NA NA Rat Human +DTXSID4022571 Css NA 0.006354 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022571 Css NA 0.0381 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022571 Css NA 0.006307 mg/L PBTK NA 50% Rat Human +DTXSID4022571 Css NA 0.0326 mg/L PBTK NA 95% Rat Human +DTXSID4022573 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4022573 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4022573 Vd NA 3.245 L/kg 1compartment NA NA Human Human -DTXSID4022573 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022573 TK.Half.Life NA 4.089 hours 1compartment NA NA Human Human -DTXSID4022573 Css NA 0.1088 mg/L 3compartmentss NA 50% Human Human -DTXSID4022573 Css NA 0.8761 mg/L 3compartmentss NA 95% Human Human -DTXSID4022573 Css NA 0.1038 mg/L PBTK NA 50% Human Human -DTXSID4022573 Css NA 0.6589 mg/L PBTK NA 95% Human Human -DTXSID4022573 Clint NA 3.879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4022573 Vd NA 3.244 L/kg 1compartment NA NA Human Human +DTXSID4022573 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4022573 TK.Half.Life NA 21.68 hours 1compartment NA NA Human Human +DTXSID4022573 Css NA 0.655 mg/L 3compartmentss NA 50% Human Human +DTXSID4022573 Css NA 2.882 mg/L 3compartmentss NA 95% Human Human +DTXSID4022573 Css NA 0.714 mg/L PBTK NA 50% Human Human +DTXSID4022573 Css NA 3.142 mg/L PBTK NA 95% Human Human +DTXSID4022573 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4022573 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4022573 Vd NA 3.264 L/kg 1compartment NA NA Rat Human DTXSID4022573 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022573 TK.Half.Life NA 2.194 hours 1compartment NA NA Rat Human -DTXSID4022573 Css NA 0.04896 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022573 Css NA 0.3435 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022573 Css NA 0.04692 mg/L PBTK NA 50% Rat Human -DTXSID4022573 Css NA 0.2258 mg/L PBTK NA 95% Rat Human +DTXSID4022573 TK.Half.Life NA 7.423 hours 1compartment NA NA Rat Human +DTXSID4022573 Css NA 0.03779 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022573 Css NA 0.1552 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022573 Css NA 0.04266 mg/L PBTK NA 50% Rat Human +DTXSID4022573 Css NA 0.1752 mg/L PBTK NA 95% Rat Human DTXSID4022577 Clint 0.3894 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4022577 Fup 0.32 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID4022577 Vd NA 0.85 L/kg 1compartment NA NA Human Human +DTXSID4022577 Vd NA 0.8502 L/kg 1compartment NA NA Human Human DTXSID4022577 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4022577 TK.Half.Life NA 10.55 hours 1compartment NA NA Human Human -DTXSID4022577 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID4022577 Css NA 5.046 mg/L 3compartmentss NA 95% Human Human -DTXSID4022577 Css NA 0.9005 mg/L PBTK NA 50% Human Human -DTXSID4022577 Css NA 3.341 mg/L PBTK NA 95% Human Human +DTXSID4022577 TK.Half.Life NA 10.56 hours 1compartment NA NA Human Human +DTXSID4022577 Css NA 1.247 mg/L 3compartmentss NA 50% Human Human +DTXSID4022577 Css NA 4.594 mg/L 3compartmentss NA 95% Human Human +DTXSID4022577 Css NA 0.9708 mg/L PBTK NA 50% Human Human +DTXSID4022577 Css NA 3.581 mg/L PBTK NA 95% Human Human DTXSID4022577 Clint 31.04 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4022577 Fup 0.35 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID4022577 Vd NA 0.8862 L/kg 1compartment NA NA Rat Rat +DTXSID4022577 Vd 2.3 0.8862 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID4022577 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4022577 TK.Half.Life NA 0.4606 hours 1compartment NA NA Rat Rat -DTXSID4022577 Css NA 0.02136 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4022577 Css NA 0.1346 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4022577 Css NA 0.01625 mg/L PBTK NA 50% Rat Rat -DTXSID4022577 Css NA 0.0888 mg/L PBTK NA 95% Rat Rat -DTXSID4022579 Clint NA 21.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022579 Fup NA 0.211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022579 Vd NA 2.185 L/kg 1compartment NA NA Human Human -DTXSID4022579 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022579 TK.Half.Life NA 4.193 hours 1compartment NA NA Human Human -DTXSID4022579 Css NA 0.1419 mg/L 3compartmentss NA 50% Human Human -DTXSID4022579 Css NA 0.9461 mg/L 3compartmentss NA 95% Human Human -DTXSID4022579 Css NA 0.1074 mg/L PBTK NA 50% Human Human -DTXSID4022579 Css NA 0.6737 mg/L PBTK NA 95% Human Human -DTXSID4022579 Clint NA 21.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022579 Fup NA 0.211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022579 Vd NA 1.769 L/kg 1compartment NA NA Rat Human -DTXSID4022579 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022579 TK.Half.Life NA 1.531 hours 1compartment NA NA Rat Human -DTXSID4022579 Css NA 0.07693 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022579 Css NA 0.3798 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022579 Css NA 0.0562 mg/L PBTK NA 50% Rat Human -DTXSID4022579 Css NA 0.2555 mg/L PBTK NA 95% Rat Human +DTXSID4022577 TK.Half.Life 0.079 0.4606 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID4022577 Css 0.002 0.004505 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID4022577 Css 0.002 0.02573 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID4022577 Css 0.002 0.003644 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID4022577 Css 0.002 0.02078 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID4022579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022579 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022579 Vd NA 2.272 L/kg 1compartment NA NA Human Human +DTXSID4022579 Days.Css NA 20 Days PBTK NA NA Human Human +DTXSID4022579 TK.Half.Life NA 110.7 hours 1compartment NA NA Human Human +DTXSID4022579 Css NA 5.028 mg/L 3compartmentss NA 50% Human Human +DTXSID4022579 Css NA 16.48 mg/L 3compartmentss NA 95% Human Human +DTXSID4022579 Css NA 3.885 mg/L PBTK NA 50% Human Human +DTXSID4022579 Css NA 11.12 mg/L PBTK NA 95% Human Human +DTXSID4022579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022579 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022579 Vd NA 1.841 L/kg 1compartment NA NA Rat Human +DTXSID4022579 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID4022579 TK.Half.Life NA 20.5 hours 1compartment NA NA Rat Human +DTXSID4022579 Css NA 0.3157 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022579 Css NA 0.8887 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022579 Css NA 0.2439 mg/L PBTK NA 50% Rat Human +DTXSID4022579 Css NA 0.5774 mg/L PBTK NA 95% Rat Human DTXSID4022600 Clint 0.511 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID4022600 Fup 0.3282 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID4022600 Vd NA 2.047 L/kg 1compartment NA NA Human Human DTXSID4022600 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID4022600 TK.Half.Life NA 21.59 hours 1compartment NA NA Human Human -DTXSID4022600 Css NA 0.8732 mg/L 3compartmentss NA 50% Human Human -DTXSID4022600 Css NA 4.485 mg/L 3compartmentss NA 95% Human Human -DTXSID4022600 Css NA 0.849 mg/L PBTK NA 50% Human Human -DTXSID4022600 Css NA 3.297 mg/L PBTK NA 95% Human Human +DTXSID4022600 Css NA 0.8491 mg/L 3compartmentss NA 50% Human Human +DTXSID4022600 Css NA 4.39 mg/L 3compartmentss NA 95% Human Human +DTXSID4022600 Css NA 0.8247 mg/L PBTK NA 50% Human Human +DTXSID4022600 Css NA 3.208 mg/L PBTK NA 95% Human Human DTXSID4022600 Clint 0.511 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID4022600 Fup 0.3282 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID4022600 Vd NA 2.039 L/kg 1compartment NA NA Rat Human DTXSID4022600 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID4022600 TK.Half.Life NA 9.608 hours 1compartment NA NA Rat Human -DTXSID4022600 Css NA 0.3126 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022600 Css NA 1.353 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022600 Css NA 0.2987 mg/L PBTK NA 50% Rat Human -DTXSID4022600 Css NA 0.9264 mg/L PBTK NA 95% Rat Human -DTXSID4022602 Clint NA 2.256 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4022600 Css NA 0.07009 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022600 Css NA 0.3136 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022600 Css NA 0.06919 mg/L PBTK NA 50% Rat Human +DTXSID4022600 Css NA 0.2202 mg/L PBTK NA 95% Rat Human +DTXSID4022602 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4022602 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4022602 Vd NA 1.233 L/kg 1compartment NA NA Human Human -DTXSID4022602 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022602 TK.Half.Life NA 2.529 hours 1compartment NA NA Human Human -DTXSID4022602 Css NA 0.2003 mg/L 3compartmentss NA 50% Human Human -DTXSID4022602 Css NA 1.463 mg/L 3compartmentss NA 95% Human Human -DTXSID4022602 Css NA 0.1748 mg/L PBTK NA 50% Human Human -DTXSID4022602 Css NA 1.002 mg/L PBTK NA 95% Human Human -DTXSID4022602 Clint NA 2.256 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4022602 Vd NA 1.226 L/kg 1compartment NA NA Human Human +DTXSID4022602 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4022602 TK.Half.Life NA 9.985 hours 1compartment NA NA Human Human +DTXSID4022602 Css NA 0.3687 mg/L 3compartmentss NA 50% Human Human +DTXSID4022602 Css NA 2.313 mg/L 3compartmentss NA 95% Human Human +DTXSID4022602 Css NA 0.3242 mg/L PBTK NA 50% Human Human +DTXSID4022602 Css NA 1.577 mg/L PBTK NA 95% Human Human +DTXSID4022602 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4022602 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4022602 Vd NA 1.137 L/kg 1compartment NA NA Rat Human +DTXSID4022602 Vd NA 1.132 L/kg 1compartment NA NA Rat Human DTXSID4022602 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022602 TK.Half.Life NA 1.171 hours 1compartment NA NA Rat Human -DTXSID4022602 Css NA 0.08588 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022602 Css NA 0.5495 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022602 Css NA 0.07403 mg/L PBTK NA 50% Rat Human -DTXSID4022602 Css NA 0.3453 mg/L PBTK NA 95% Rat Human -DTXSID4022652 Clint NA 0.8161 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022652 Fup NA 0.003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022652 Vd NA 1.195 L/kg 1compartment NA NA Human Human -DTXSID4022652 Days.Css NA 204 Days PBTK NA NA Human Human -DTXSID4022652 TK.Half.Life NA 794.9 hours 1compartment NA NA Human Human -DTXSID4022652 Css NA 115.8 mg/L 3compartmentss NA 50% Human Human -DTXSID4022652 Css NA 612.4 mg/L 3compartmentss NA 95% Human Human -DTXSID4022652 Css NA 70.06 mg/L PBTK NA 50% Human Human -DTXSID4022652 Css NA 361.3 mg/L PBTK NA 95% Human Human -DTXSID4022652 Clint NA 0.8161 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022652 Fup NA 0.003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022652 Vd NA 0.8737 L/kg 1compartment NA NA Rat Human -DTXSID4022652 Days.Css NA 81 Days PBTK NA NA Rat Human -DTXSID4022652 TK.Half.Life NA 271.4 hours 1compartment NA NA Rat Human -DTXSID4022652 Css NA 53.48 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022652 Css NA 211.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022652 Css NA 30.26 mg/L PBTK NA 50% Rat Human -DTXSID4022652 Css NA 115.8 mg/L PBTK NA 95% Rat Human -DTXSID4022658 Clint NA 21.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022658 Fup NA 0.0293 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022658 Vd NA 0.2326 L/kg 1compartment NA NA Human Human +DTXSID4022602 TK.Half.Life NA 2.985 hours 1compartment NA NA Rat Human +DTXSID4022602 Css NA 0.001603 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022602 Css NA 0.009654 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022602 Css NA 0.001393 mg/L PBTK NA 50% Rat Human +DTXSID4022602 Css NA 0.006023 mg/L PBTK NA 95% Rat Human +DTXSID4022604 Clint 11 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID4022604 Fup 0.029 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4022604 Vd NA 2.539 L/kg 1compartment NA NA Human Human +DTXSID4022604 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4022604 TK.Half.Life NA 14.73 hours 1compartment NA NA Human Human +DTXSID4022604 Css NA 0.741 mg/L 3compartmentss NA 50% Human Human +DTXSID4022604 Css NA 6.603 mg/L 3compartmentss NA 95% Human Human +DTXSID4022604 Css NA 0.5343 mg/L PBTK NA 50% Human Human +DTXSID4022604 Css NA 4.317 mg/L PBTK NA 95% Human Human +DTXSID4022604 Clint 11 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID4022604 Fup 0.029 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4022604 Vd NA 2.105 L/kg 1compartment NA NA Rat Human +DTXSID4022604 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4022604 TK.Half.Life NA 5.466 hours 1compartment NA NA Rat Human +DTXSID4022604 Css NA 0.09392 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022604 Css NA 0.6747 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022604 Css NA 0.06637 mg/L PBTK NA 50% Rat Human +DTXSID4022604 Css NA 0.4459 mg/L PBTK NA 95% Rat Human +DTXSID4022652 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022652 Fup 0.00845 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022652 Vd NA 2.286 L/kg 1compartment NA NA Human Human +DTXSID4022652 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4022652 TK.Half.Life NA 41.26 hours 1compartment NA NA Human Human +DTXSID4022652 Css NA 2.708 mg/L 3compartmentss NA 50% Human Human +DTXSID4022652 Css NA 21.22 mg/L 3compartmentss NA 95% Human Human +DTXSID4022652 Css NA 1.748 mg/L PBTK NA 50% Human Human +DTXSID4022652 Css NA 13.44 mg/L PBTK NA 95% Human Human +DTXSID4022652 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022652 Fup 0.00845 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022652 Vd NA 1.697 L/kg 1compartment NA NA Rat Human +DTXSID4022652 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4022652 TK.Half.Life NA 11.45 hours 1compartment NA NA Rat Human +DTXSID4022652 Css NA 0.3518 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022652 Css NA 2.325 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022652 Css NA 0.2227 mg/L PBTK NA 50% Rat Human +DTXSID4022652 Css NA 1.414 mg/L PBTK NA 95% Rat Human +DTXSID4022658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022658 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022658 Vd NA 0.4075 L/kg 1compartment NA NA Human Human DTXSID4022658 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022658 TK.Half.Life NA 1.582 hours 1compartment NA NA Human Human -DTXSID4022658 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human -DTXSID4022658 Css NA 10.75 mg/L 3compartmentss NA 95% Human Human -DTXSID4022658 Css NA 0.6772 mg/L PBTK NA 50% Human Human -DTXSID4022658 Css NA 6.217 mg/L PBTK NA 95% Human Human -DTXSID4022658 Clint NA 21.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022658 Fup NA 0.0293 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022658 Vd NA 0.2152 L/kg 1compartment NA NA Rat Human +DTXSID4022658 TK.Half.Life NA 0.8585 hours 1compartment NA NA Human Human +DTXSID4022658 Css NA 0.09944 mg/L 3compartmentss NA 50% Human Human +DTXSID4022658 Css NA 0.9279 mg/L 3compartmentss NA 95% Human Human +DTXSID4022658 Css NA 0.06278 mg/L PBTK NA 50% Human Human +DTXSID4022658 Css NA 0.5544 mg/L PBTK NA 95% Human Human +DTXSID4022658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022658 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022658 Vd NA 0.3685 L/kg 1compartment NA NA Rat Human DTXSID4022658 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022658 TK.Half.Life NA 0.9452 hours 1compartment NA NA Rat Human -DTXSID4022658 Css NA 0.6378 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022658 Css NA 4.829 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022658 Css NA 0.3514 mg/L PBTK NA 50% Rat Human -DTXSID4022658 Css NA 2.62 mg/L PBTK NA 95% Rat Human +DTXSID4022658 TK.Half.Life NA 0.4443 hours 1compartment NA NA Rat Human +DTXSID4022658 Css NA 0.00101 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022658 Css NA 0.008648 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022658 Css NA 0.0006024 mg/L PBTK NA 50% Rat Human +DTXSID4022658 Css NA 0.004933 mg/L PBTK NA 95% Rat Human DTXSID40227299 Clint 3.037 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID40227299 Fup 0.19 NA NA https://doi.org/10.1124/dmd.117.077040 NA Human Human -DTXSID40227299 Vd NA 2.176 L/kg 1compartment NA NA Human Human -DTXSID40227299 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID40227299 TK.Half.Life NA 8.888 hours 1compartment NA NA Human Human -DTXSID40227299 Css NA 0.3123 mg/L 3compartmentss NA 50% Human Human -DTXSID40227299 Css NA 2.02 mg/L 3compartmentss NA 95% Human Human -DTXSID40227299 Css NA 0.3162 mg/L PBTK NA 50% Human Human -DTXSID40227299 Css NA 1.644 mg/L PBTK NA 95% Human Human +DTXSID40227299 Vd NA 2.922 L/kg 1compartment NA NA Human Human +DTXSID40227299 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40227299 TK.Half.Life NA 13.64 hours 1compartment NA NA Human Human +DTXSID40227299 Css NA 0.3328 mg/L 3compartmentss NA 50% Human Human +DTXSID40227299 Css NA 2.227 mg/L 3compartmentss NA 95% Human Human +DTXSID40227299 Css NA 0.3598 mg/L PBTK NA 50% Human Human +DTXSID40227299 Css NA 1.893 mg/L PBTK NA 95% Human Human DTXSID40227299 Clint 3.037 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID40227299 Fup 0.19 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human -DTXSID40227299 Vd NA 2.134 L/kg 1compartment NA NA Rat Human +DTXSID40227299 Vd NA 2.927 L/kg 1compartment NA NA Rat Human DTXSID40227299 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID40227299 TK.Half.Life NA 5.227 hours 1compartment NA NA Rat Human -DTXSID40227299 Css NA 0.1504 mg/L 3compartmentss NA 50% Rat Human -DTXSID40227299 Css NA 0.7404 mg/L 3compartmentss NA 95% Rat Human -DTXSID40227299 Css NA 0.1534 mg/L PBTK NA 50% Rat Human -DTXSID40227299 Css NA 0.5665 mg/L PBTK NA 95% Rat Human +DTXSID40227299 TK.Half.Life NA 8.086 hours 1compartment NA NA Rat Human +DTXSID40227299 Css NA 0.03629 mg/L 3compartmentss NA 50% Rat Human +DTXSID40227299 Css NA 0.1839 mg/L 3compartmentss NA 95% Rat Human +DTXSID40227299 Css NA 0.04073 mg/L PBTK NA 50% Rat Human +DTXSID40227299 Css NA 0.1508 mg/L PBTK NA 95% Rat Human DTXSID4022731 Clint 2.375 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4022731 Fup 0.5141 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID4022731 Vd NA 0.6982 L/kg 1compartment NA NA Human Human +DTXSID4022731 Vd NA 2.069 L/kg 1compartment NA NA Human Human DTXSID4022731 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022731 TK.Half.Life NA 2.015 hours 1compartment NA NA Human Human -DTXSID4022731 Css NA 0.1648 mg/L 3compartmentss NA 50% Human Human -DTXSID4022731 Css NA 1.244 mg/L 3compartmentss NA 95% Human Human -DTXSID4022731 Css NA 0.1694 mg/L PBTK NA 50% Human Human -DTXSID4022731 Css NA 0.9291 mg/L PBTK NA 95% Human Human +DTXSID4022731 TK.Half.Life NA 8.702 hours 1compartment NA NA Human Human +DTXSID4022731 Css NA 0.3167 mg/L 3compartmentss NA 50% Human Human +DTXSID4022731 Css NA 1.5 mg/L 3compartmentss NA 95% Human Human +DTXSID4022731 Css NA 0.3349 mg/L PBTK NA 50% Human Human +DTXSID4022731 Css NA 1.589 mg/L PBTK NA 95% Human Human DTXSID4022731 Clint 2.375 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID4022731 Fup 0.5141 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID4022731 Vd NA 0.5141 L/kg 1compartment NA NA Rat Human +DTXSID4022731 Vd NA 1.333 L/kg 1compartment NA NA Rat Human DTXSID4022731 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022731 TK.Half.Life NA 1.295 hours 1compartment NA NA Rat Human -DTXSID4022731 Css NA 0.1548 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022731 Css NA 0.7611 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022731 Css NA 0.1616 mg/L PBTK NA 50% Rat Human -DTXSID4022731 Css NA 0.5567 mg/L PBTK NA 95% Rat Human -DTXSID4022735 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022735 Fup NA 0.5171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022735 Vd NA 0.4658 L/kg 1compartment NA NA Human Human +DTXSID4022731 TK.Half.Life NA 3.447 hours 1compartment NA NA Rat Human +DTXSID4022731 Css NA 0.04502 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022731 Css NA 0.1416 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022731 Css NA 0.04942 mg/L PBTK NA 50% Rat Human +DTXSID4022731 Css NA 0.1554 mg/L PBTK NA 95% Rat Human +DTXSID4022735 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022735 Fup 0.708 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022735 Vd NA 0.4036 L/kg 1compartment NA NA Human Human DTXSID4022735 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022735 TK.Half.Life NA 5.83 hours 1compartment NA NA Human Human -DTXSID4022735 Css NA 1.506 mg/L 3compartmentss NA 50% Human Human -DTXSID4022735 Css NA 8.136 mg/L 3compartmentss NA 95% Human Human -DTXSID4022735 Css NA 1.091 mg/L PBTK NA 50% Human Human -DTXSID4022735 Css NA 4.979 mg/L PBTK NA 95% Human Human -DTXSID4022735 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022735 Fup NA 0.5171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022735 Vd NA 0.4869 L/kg 1compartment NA NA Rat Human +DTXSID4022735 TK.Half.Life NA 3.689 hours 1compartment NA NA Human Human +DTXSID4022735 Css NA 0.6688 mg/L 3compartmentss NA 50% Human Human +DTXSID4022735 Css NA 4.126 mg/L 3compartmentss NA 95% Human Human +DTXSID4022735 Css NA 0.4795 mg/L PBTK NA 50% Human Human +DTXSID4022735 Css NA 2.545 mg/L PBTK NA 95% Human Human +DTXSID4022735 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022735 Fup 0.708 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022735 Vd NA 0.4252 L/kg 1compartment NA NA Rat Human DTXSID4022735 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022735 TK.Half.Life NA 2.076 hours 1compartment NA NA Rat Human -DTXSID4022735 Css NA 0.4055 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022735 Css NA 1.929 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022735 Css NA 0.2794 mg/L PBTK NA 50% Rat Human -DTXSID4022735 Css NA 1.114 mg/L PBTK NA 95% Rat Human -DTXSID4022783 Clint NA 0.5851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4022735 TK.Half.Life NA 1.324 hours 1compartment NA NA Rat Human +DTXSID4022735 Css NA 0.003499 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022735 Css NA 0.0229 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022735 Css NA 0.0024 mg/L PBTK NA 50% Rat Human +DTXSID4022735 Css NA 0.01325 mg/L PBTK NA 95% Rat Human +DTXSID40227810 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40227810 Fup 0.529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40227810 Vd NA 1.053 L/kg 1compartment NA NA Human Human +DTXSID40227810 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40227810 TK.Half.Life NA 13.88 hours 1compartment NA NA Human Human +DTXSID40227810 Css NA 1.383 mg/L 3compartmentss NA 50% Human Human +DTXSID40227810 Css NA 7.694 mg/L 3compartmentss NA 95% Human Human +DTXSID40227810 Css NA 1.118 mg/L PBTK NA 50% Human Human +DTXSID40227810 Css NA 4.962 mg/L PBTK NA 95% Human Human +DTXSID40227810 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40227810 Fup 0.529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40227810 Vd NA 0.9351 L/kg 1compartment NA NA Rat Human +DTXSID40227810 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40227810 TK.Half.Life NA 3.97 hours 1compartment NA NA Rat Human +DTXSID40227810 Css NA 0.08442 mg/L 3compartmentss NA 50% Rat Human +DTXSID40227810 Css NA 0.4409 mg/L 3compartmentss NA 95% Rat Human +DTXSID40227810 Css NA 0.06834 mg/L PBTK NA 50% Rat Human +DTXSID40227810 Css NA 0.2737 mg/L PBTK NA 95% Rat Human +DTXSID4022783 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4022783 Fup 0.22 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4022783 Vd NA 0.2722 L/kg 1compartment NA NA Human Human DTXSID4022783 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022783 TK.Half.Life NA 3.995 hours 1compartment NA NA Human Human -DTXSID4022783 Css NA 1.845 mg/L 3compartmentss NA 50% Human Human -DTXSID4022783 Css NA 7.226 mg/L 3compartmentss NA 95% Human Human -DTXSID4022783 Css NA 1.172 mg/L PBTK NA 50% Human Human -DTXSID4022783 Css NA 4.321 mg/L PBTK NA 95% Human Human -DTXSID4022783 Clint NA 0.5851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4022783 TK.Half.Life NA 8.005 hours 1compartment NA NA Human Human +DTXSID4022783 Css NA 2.028 mg/L 3compartmentss NA 50% Human Human +DTXSID4022783 Css NA 7.853 mg/L 3compartmentss NA 95% Human Human +DTXSID4022783 Css NA 1.287 mg/L PBTK NA 50% Human Human +DTXSID4022783 Css NA 4.754 mg/L PBTK NA 95% Human Human +DTXSID4022783 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4022783 Fup 0.22 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4022783 Vd NA 0.279 L/kg 1compartment NA NA Rat Human DTXSID4022783 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022783 TK.Half.Life NA 1.874 hours 1compartment NA NA Rat Human -DTXSID4022783 Css NA 0.7016 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022783 Css NA 2.177 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022783 Css NA 0.42 mg/L PBTK NA 50% Rat Human -DTXSID4022783 Css NA 1.224 mg/L PBTK NA 95% Rat Human -DTXSID4022785 Clint NA 1.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4022783 TK.Half.Life NA 2.796 hours 1compartment NA NA Rat Human +DTXSID4022783 Css NA 0.01092 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022783 Css NA 0.04332 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022783 Css NA 0.006577 mg/L PBTK NA 50% Rat Human +DTXSID4022783 Css NA 0.02497 mg/L PBTK NA 95% Rat Human +DTXSID4022785 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4022785 Fup 0.95 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4022785 Vd NA 1.173 L/kg 1compartment NA NA Human Human +DTXSID4022785 Vd NA 0.6575 L/kg 1compartment NA NA Human Human DTXSID4022785 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022785 TK.Half.Life NA 2.453 hours 1compartment NA NA Human Human -DTXSID4022785 Css NA 0.2244 mg/L 3compartmentss NA 50% Human Human -DTXSID4022785 Css NA 1.501 mg/L 3compartmentss NA 95% Human Human -DTXSID4022785 Css NA 0.196 mg/L PBTK NA 50% Human Human -DTXSID4022785 Css NA 1.025 mg/L PBTK NA 95% Human Human -DTXSID4022785 Clint NA 1.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4022785 TK.Half.Life NA 4.478 hours 1compartment NA NA Human Human +DTXSID4022785 Css NA 0.5169 mg/L 3compartmentss NA 50% Human Human +DTXSID4022785 Css NA 2.874 mg/L 3compartmentss NA 95% Human Human +DTXSID4022785 Css NA 0.4095 mg/L PBTK NA 50% Human Human +DTXSID4022785 Css NA 1.861 mg/L PBTK NA 95% Human Human +DTXSID4022785 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4022785 Fup 0.95 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4022785 Vd NA 1.12 L/kg 1compartment NA NA Rat Human +DTXSID4022785 Vd NA 0.6926 L/kg 1compartment NA NA Rat Human DTXSID4022785 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022785 TK.Half.Life NA 1.168 hours 1compartment NA NA Rat Human -DTXSID4022785 Css NA 0.09184 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022785 Css NA 0.5394 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022785 Css NA 0.07958 mg/L PBTK NA 50% Rat Human -DTXSID4022785 Css NA 0.3375 mg/L PBTK NA 95% Rat Human +DTXSID4022785 TK.Half.Life NA 1.607 hours 1compartment NA NA Rat Human +DTXSID4022785 Css NA 0.00265 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022785 Css NA 0.01577 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022785 Css NA 0.00204 mg/L PBTK NA 50% Rat Human +DTXSID4022785 Css NA 0.009834 mg/L PBTK NA 95% Rat Human DTXSID4022787 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID4022787 Fup 0.01 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human DTXSID4022787 Vd NA 0.2203 L/kg 1compartment NA NA Human Human DTXSID4022787 Days.Css NA 38 Days PBTK NA NA Human Human DTXSID4022787 TK.Half.Life NA 142.9 hours 1compartment NA NA Human Human -DTXSID4022787 Css NA 61.86 mg/L 3compartmentss NA 50% Human Human -DTXSID4022787 Css NA 515.9 mg/L 3compartmentss NA 95% Human Human -DTXSID4022787 Css NA 56.9 mg/L PBTK NA 50% Human Human -DTXSID4022787 Css NA 335.1 mg/L PBTK NA 95% Human Human +DTXSID4022787 Css NA 64.09 mg/L 3compartmentss NA 50% Human Human +DTXSID4022787 Css NA 397.8 mg/L 3compartmentss NA 95% Human Human +DTXSID4022787 Css NA 64.09 mg/L PBTK NA 50% Human Human +DTXSID4022787 Css NA 397.8 mg/L PBTK NA 95% Human Human DTXSID4022787 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID4022787 Fup 0.01 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human DTXSID4022787 Vd NA 0.1997 L/kg 1compartment NA NA Rat Human DTXSID4022787 Days.Css NA 9 Days PBTK NA NA Rat Human DTXSID4022787 TK.Half.Life NA 44.07 hours 1compartment NA NA Rat Human -DTXSID4022787 Css NA 19.52 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022787 Css NA 153.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022787 Css NA 17.39 mg/L PBTK NA 50% Rat Human -DTXSID4022787 Css NA 92.75 mg/L PBTK NA 95% Rat Human -DTXSID4022789 Clint NA 4.898 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022789 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022789 Vd NA 2.201 L/kg 1compartment NA NA Human Human +DTXSID4022787 Css NA 3.882 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022787 Css NA 20.8 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022787 Css NA 4.019 mg/L PBTK NA 50% Rat Human +DTXSID4022787 Css NA 21.55 mg/L PBTK NA 95% Rat Human +DTXSID4022789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022789 Fup 0.184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022789 Vd NA 2.594 L/kg 1compartment NA NA Human Human DTXSID4022789 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022789 TK.Half.Life NA 12.05 hours 1compartment NA NA Human Human -DTXSID4022789 Css NA 0.6023 mg/L 3compartmentss NA 50% Human Human -DTXSID4022789 Css NA 4.562 mg/L 3compartmentss NA 95% Human Human -DTXSID4022789 Css NA 0.505 mg/L PBTK NA 50% Human Human -DTXSID4022789 Css NA 3.201 mg/L PBTK NA 95% Human Human -DTXSID4022789 Clint NA 4.898 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022789 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022789 Vd NA 2.171 L/kg 1compartment NA NA Rat Human +DTXSID4022789 TK.Half.Life NA 3.593 hours 1compartment NA NA Human Human +DTXSID4022789 Css NA 0.07367 mg/L 3compartmentss NA 50% Human Human +DTXSID4022789 Css NA 0.6075 mg/L 3compartmentss NA 95% Human Human +DTXSID4022789 Css NA 0.07022 mg/L PBTK NA 50% Human Human +DTXSID4022789 Css NA 0.4779 mg/L PBTK NA 95% Human Human +DTXSID4022789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022789 Fup 0.184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022789 Vd NA 2.588 L/kg 1compartment NA NA Rat Human DTXSID4022789 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022789 TK.Half.Life NA 7.055 hours 1compartment NA NA Rat Human -DTXSID4022789 Css NA 0.3147 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022789 Css NA 1.794 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022789 Css NA 0.2502 mg/L PBTK NA 50% Rat Human -DTXSID4022789 Css NA 1.147 mg/L PBTK NA 95% Rat Human +DTXSID4022789 TK.Half.Life NA 2.026 hours 1compartment NA NA Rat Human +DTXSID4022789 Css NA 0.009279 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022789 Css NA 0.05592 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022789 Css NA 0.008991 mg/L PBTK NA 50% Rat Human +DTXSID4022789 Css NA 0.04539 mg/L PBTK NA 95% Rat Human DTXSID4022810 Clint 14 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.30.12.1446 NA Human Human DTXSID4022810 Fup 0.01 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human -DTXSID4022810 Vd NA 1.214 L/kg 1compartment NA NA Human Human -DTXSID4022810 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022810 TK.Half.Life NA 4.321 hours 1compartment NA NA Human Human -DTXSID4022810 Css NA 0.423 mg/L 3compartmentss NA 50% Human Human -DTXSID4022810 Css NA 5.206 mg/L 3compartmentss NA 95% Human Human -DTXSID4022810 Css NA 0.324 mg/L PBTK NA 50% Human Human -DTXSID4022810 Css NA 3.348 mg/L PBTK NA 95% Human Human +DTXSID4022810 Vd NA 2.875 L/kg 1compartment NA NA Human Human +DTXSID4022810 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID4022810 TK.Half.Life NA 91.66 hours 1compartment NA NA Human Human +DTXSID4022810 Css NA 3.548 mg/L 3compartmentss NA 50% Human Human +DTXSID4022810 Css NA 23.09 mg/L 3compartmentss NA 95% Human Human +DTXSID4022810 Css NA 2.874 mg/L PBTK NA 50% Human Human +DTXSID4022810 Css NA 18.7 mg/L PBTK NA 95% Human Human DTXSID4022810 Clint 14 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.30.12.1446 NA Rat Human DTXSID4022810 Fup 0.01 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human -DTXSID4022810 Vd NA 1.1 L/kg 1compartment NA NA Rat Human -DTXSID4022810 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022810 TK.Half.Life NA 2.436 hours 1compartment NA NA Rat Human -DTXSID4022810 Css NA 0.244 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022810 Css NA 2.417 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022810 Css NA 0.1778 mg/L PBTK NA 50% Rat Human -DTXSID4022810 Css NA 1.505 mg/L PBTK NA 95% Rat Human -DTXSID4022812 Clint NA 23.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4022810 Vd NA 2.162 L/kg 1compartment NA NA Rat Human +DTXSID4022810 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID4022810 TK.Half.Life NA 17.04 hours 1compartment NA NA Rat Human +DTXSID4022810 Css NA 0.4361 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022810 Css NA 2.505 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022810 Css NA 0.3659 mg/L PBTK NA 50% Rat Human +DTXSID4022810 Css NA 2.101 mg/L PBTK NA 95% Rat Human +DTXSID4022812 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4022812 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4022812 Vd NA 0.4629 L/kg 1compartment NA NA Human Human DTXSID4022812 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022812 TK.Half.Life NA 0.6383 hours 1compartment NA NA Human Human -DTXSID4022812 Css NA 0.05053 mg/L 3compartmentss NA 50% Human Human -DTXSID4022812 Css NA 0.3729 mg/L 3compartmentss NA 95% Human Human -DTXSID4022812 Css NA 0.03728 mg/L PBTK NA 50% Human Human -DTXSID4022812 Css NA 0.2485 mg/L PBTK NA 95% Human Human -DTXSID4022812 Clint NA 23.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4022812 TK.Half.Life NA 1.386 hours 1compartment NA NA Human Human +DTXSID4022812 Css NA 0.27 mg/L 3compartmentss NA 50% Human Human +DTXSID4022812 Css NA 1.513 mg/L 3compartmentss NA 95% Human Human +DTXSID4022812 Css NA 0.1963 mg/L PBTK NA 50% Human Human +DTXSID4022812 Css NA 1.103 mg/L PBTK NA 95% Human Human +DTXSID4022812 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4022812 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4022812 Vd NA 0.4424 L/kg 1compartment NA NA Rat Human DTXSID4022812 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022812 TK.Half.Life NA 0.3316 hours 1compartment NA NA Rat Human -DTXSID4022812 Css NA 0.04298 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022812 Css NA 0.2337 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022812 Css NA 0.03035 mg/L PBTK NA 50% Rat Human -DTXSID4022812 Css NA 0.152 mg/L PBTK NA 95% Rat Human +DTXSID4022812 TK.Half.Life NA 0.7716 hours 1compartment NA NA Rat Human +DTXSID4022812 Css NA 0.0307 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022812 Css NA 0.1248 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022812 Css NA 0.0232 mg/L PBTK NA 50% Rat Human +DTXSID4022812 Css NA 0.09432 mg/L PBTK NA 95% Rat Human DTXSID4022814 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4022814 Fup NA 0.0022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022814 Vd NA 1.376 L/kg 1compartment NA NA Human Human -DTXSID4022814 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID4022814 TK.Half.Life NA 4111 hours 1compartment NA NA Human Human -DTXSID4022814 Css NA 469.8 mg/L 3compartmentss NA 50% Human Human -DTXSID4022814 Css NA 2774 mg/L 3compartmentss NA 95% Human Human -DTXSID4022814 Css NA 294.8 mg/L PBTK NA 50% Human Human -DTXSID4022814 Css NA 1615 mg/L PBTK NA 95% Human Human +DTXSID4022814 Vd NA 0.1768 L/kg 1compartment NA NA Human Human +DTXSID4022814 Days.Css NA 134 Days PBTK NA NA Human Human +DTXSID4022814 TK.Half.Life NA 520 hours 1compartment NA NA Human Human +DTXSID4022814 Css NA 424.5 mg/L 3compartmentss NA 50% Human Human +DTXSID4022814 Css NA 2377 mg/L 3compartmentss NA 95% Human Human +DTXSID4022814 Css NA 247 mg/L PBTK NA 50% Human Human +DTXSID4022814 Css NA 1359 mg/L PBTK NA 95% Human Human DTXSID4022814 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4022814 Fup NA 0.0022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022814 Vd NA 1.032 L/kg 1compartment NA NA Rat Human -DTXSID4022814 Days.Css NA 280 Days PBTK NA NA Rat Human -DTXSID4022814 TK.Half.Life NA 1038 hours 1compartment NA NA Rat Human -DTXSID4022814 Css NA 132.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022814 Css NA 678.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022814 Css NA 78.31 mg/L PBTK NA 50% Rat Human -DTXSID4022814 Css NA 373.2 mg/L PBTK NA 95% Rat Human +DTXSID4022814 Vd NA 0.171 L/kg 1compartment NA NA Rat Human +DTXSID4022814 Days.Css NA 40 Days PBTK NA NA Rat Human +DTXSID4022814 TK.Half.Life NA 171.4 hours 1compartment NA NA Rat Human +DTXSID4022814 Css NA 7.844 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022814 Css NA 59.97 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022814 Css NA 4.306 mg/L PBTK NA 50% Rat Human +DTXSID4022814 Css NA 33.29 mg/L PBTK NA 95% Rat Human DTXSID4022816 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4022816 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022816 Vd NA 0.1968 L/kg 1compartment NA NA Human Human -DTXSID4022816 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4022816 TK.Half.Life NA 15.6 hours 1compartment NA NA Human Human -DTXSID4022816 Css NA 15.07 mg/L 3compartmentss NA 50% Human Human -DTXSID4022816 Css NA 124.2 mg/L 3compartmentss NA 95% Human Human -DTXSID4022816 Css NA 8.852 mg/L PBTK NA 50% Human Human -DTXSID4022816 Css NA 71.82 mg/L PBTK NA 95% Human Human +DTXSID4022816 Vd NA 0.1663 L/kg 1compartment NA NA Human Human +DTXSID4022816 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4022816 TK.Half.Life NA 8.426 hours 1compartment NA NA Human Human +DTXSID4022816 Css NA 5.159 mg/L 3compartmentss NA 50% Human Human +DTXSID4022816 Css NA 48.91 mg/L 3compartmentss NA 95% Human Human +DTXSID4022816 Css NA 2.995 mg/L PBTK NA 50% Human Human +DTXSID4022816 Css NA 27.84 mg/L PBTK NA 95% Human Human DTXSID4022816 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4022816 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022816 Vd NA 0.1921 L/kg 1compartment NA NA Rat Human -DTXSID4022816 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4022816 TK.Half.Life NA 9.754 hours 1compartment NA NA Rat Human -DTXSID4022816 Css NA 7.944 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022816 Css NA 52.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022816 Css NA 4.342 mg/L PBTK NA 50% Rat Human -DTXSID4022816 Css NA 28.72 mg/L PBTK NA 95% Rat Human -DTXSID4022862 Clint NA 8.288 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022862 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022862 Vd NA 2.837 L/kg 1compartment NA NA Human Human -DTXSID4022862 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID4022862 TK.Half.Life NA 82.21 hours 1compartment NA NA Human Human -DTXSID4022862 Css NA 3.867 mg/L 3compartmentss NA 50% Human Human -DTXSID4022862 Css NA 24.31 mg/L 3compartmentss NA 95% Human Human -DTXSID4022862 Css NA 2.634 mg/L PBTK NA 50% Human Human -DTXSID4022862 Css NA 16.08 mg/L PBTK NA 95% Human Human -DTXSID4022862 Clint NA 8.288 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022862 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022862 Vd NA 2.125 L/kg 1compartment NA NA Rat Human -DTXSID4022862 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID4022862 TK.Half.Life NA 15.11 hours 1compartment NA NA Rat Human -DTXSID4022862 Css NA 2.16 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022862 Css NA 10.19 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022862 Css NA 1.398 mg/L PBTK NA 50% Rat Human -DTXSID4022862 Css NA 6.371 mg/L PBTK NA 95% Rat Human -DTXSID4022866 Clint NA 75.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022866 Fup NA 0.0117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022866 Vd NA 3.083 L/kg 1compartment NA NA Human Human -DTXSID4022866 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4022866 TK.Half.Life NA 26.35 hours 1compartment NA NA Human Human -DTXSID4022866 Css NA 0.9802 mg/L 3compartmentss NA 50% Human Human -DTXSID4022866 Css NA 6.19 mg/L 3compartmentss NA 95% Human Human -DTXSID4022866 Css NA 0.672 mg/L PBTK NA 50% Human Human -DTXSID4022866 Css NA 4.163 mg/L PBTK NA 95% Human Human -DTXSID4022866 Clint NA 75.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022866 Fup NA 0.0117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022866 Vd NA 2.309 L/kg 1compartment NA NA Rat Human -DTXSID4022866 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4022866 TK.Half.Life NA 4.065 hours 1compartment NA NA Rat Human -DTXSID4022866 Css NA 0.5529 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022866 Css NA 2.783 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022866 Css NA 0.3645 mg/L PBTK NA 50% Rat Human -DTXSID4022866 Css NA 1.767 mg/L PBTK NA 95% Rat Human -DTXSID4022868 Clint NA 2.908 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022868 Fup NA 0.1105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022868 Vd NA 0.3701 L/kg 1compartment NA NA Human Human +DTXSID4022816 Vd NA 0.1655 L/kg 1compartment NA NA Rat Human +DTXSID4022816 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4022816 TK.Half.Life NA 5.527 hours 1compartment NA NA Rat Human +DTXSID4022816 Css NA 0.05622 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022816 Css NA 0.4655 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022816 Css NA 0.03056 mg/L PBTK NA 50% Rat Human +DTXSID4022816 Css NA 0.2526 mg/L PBTK NA 95% Rat Human +DTXSID4022862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022862 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022862 Vd NA 2.9 L/kg 1compartment NA NA Human Human +DTXSID4022862 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4022862 TK.Half.Life NA 41.98 hours 1compartment NA NA Human Human +DTXSID4022862 Css NA 1.826 mg/L 3compartmentss NA 50% Human Human +DTXSID4022862 Css NA 12.33 mg/L 3compartmentss NA 95% Human Human +DTXSID4022862 Css NA 1.246 mg/L PBTK NA 50% Human Human +DTXSID4022862 Css NA 8.167 mg/L PBTK NA 95% Human Human +DTXSID4022862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022862 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022862 Vd NA 2.172 L/kg 1compartment NA NA Rat Human +DTXSID4022862 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4022862 TK.Half.Life NA 7.542 hours 1compartment NA NA Rat Human +DTXSID4022862 Css NA 0.2348 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022862 Css NA 1.329 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022862 Css NA 0.1582 mg/L PBTK NA 50% Rat Human +DTXSID4022862 Css NA 0.8583 mg/L PBTK NA 95% Rat Human +DTXSID4022864 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID4022864 Fup 0.339 NA NA Williamson 2020 NA Human Human +DTXSID4022864 Vd NA 3.067 L/kg 1compartment NA NA Human Human +DTXSID4022864 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID4022864 TK.Half.Life NA 65.27 hours 1compartment NA NA Human Human +DTXSID4022864 Css NA 2.084 mg/L 3compartmentss NA 50% Human Human +DTXSID4022864 Css NA 11.34 mg/L 3compartmentss NA 95% Human Human +DTXSID4022864 Css NA 1.494 mg/L PBTK NA 50% Human Human +DTXSID4022864 Css NA 7.8 mg/L PBTK NA 95% Human Human +DTXSID4022864 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID4022864 Fup 0.339 NA NA Williamson 2020 NA Rat Human +DTXSID4022864 Vd NA 2.314 L/kg 1compartment NA NA Rat Human +DTXSID4022864 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4022864 TK.Half.Life NA 9.446 hours 1compartment NA NA Rat Human +DTXSID4022864 Css NA 0.07314 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022864 Css NA 0.4353 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022864 Css NA 0.05072 mg/L PBTK NA 50% Rat Human +DTXSID4022864 Css NA 0.2946 mg/L PBTK NA 95% Rat Human +DTXSID4022866 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022866 Fup 0.00737 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022866 Vd NA 2.96 L/kg 1compartment NA NA Human Human +DTXSID4022866 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID4022866 TK.Half.Life NA 75.27 hours 1compartment NA NA Human Human +DTXSID4022866 Css NA 3.239 mg/L 3compartmentss NA 50% Human Human +DTXSID4022866 Css NA 21.89 mg/L 3compartmentss NA 95% Human Human +DTXSID4022866 Css NA 2.199 mg/L PBTK NA 50% Human Human +DTXSID4022866 Css NA 14.44 mg/L PBTK NA 95% Human Human +DTXSID4022866 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022866 Fup 0.00737 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022866 Vd NA 2.214 L/kg 1compartment NA NA Rat Human +DTXSID4022866 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID4022866 TK.Half.Life NA 12.37 hours 1compartment NA NA Rat Human +DTXSID4022866 Css NA 0.4222 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022866 Css NA 2.516 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022866 Css NA 0.2846 mg/L PBTK NA 50% Rat Human +DTXSID4022866 Css NA 1.647 mg/L PBTK NA 95% Rat Human +DTXSID4022868 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022868 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022868 Vd NA 0.52 L/kg 1compartment NA NA Human Human DTXSID4022868 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022868 TK.Half.Life NA 3.932 hours 1compartment NA NA Human Human -DTXSID4022868 Css NA 1.625 mg/L 3compartmentss NA 50% Human Human -DTXSID4022868 Css NA 10.09 mg/L 3compartmentss NA 95% Human Human -DTXSID4022868 Css NA 1.008 mg/L PBTK NA 50% Human Human -DTXSID4022868 Css NA 5.888 mg/L PBTK NA 95% Human Human -DTXSID4022868 Clint NA 2.908 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022868 Fup NA 0.1105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022868 Vd NA 0.3398 L/kg 1compartment NA NA Rat Human +DTXSID4022868 TK.Half.Life NA 1.682 hours 1compartment NA NA Human Human +DTXSID4022868 Css NA 0.167 mg/L 3compartmentss NA 50% Human Human +DTXSID4022868 Css NA 1.078 mg/L 3compartmentss NA 95% Human Human +DTXSID4022868 Css NA 0.1129 mg/L PBTK NA 50% Human Human +DTXSID4022868 Css NA 0.6815 mg/L PBTK NA 95% Human Human +DTXSID4022868 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022868 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022868 Vd NA 0.4773 L/kg 1compartment NA NA Rat Human DTXSID4022868 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022868 TK.Half.Life NA 2.079 hours 1compartment NA NA Rat Human -DTXSID4022868 Css NA 0.7993 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022868 Css NA 3.697 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022868 Css NA 0.4658 mg/L PBTK NA 50% Rat Human -DTXSID4022868 Css NA 2.044 mg/L PBTK NA 95% Rat Human -DTXSID4022941 Clint NA 10.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022941 Fup NA 0.054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022941 Vd NA 3.072 L/kg 1compartment NA NA Human Human -DTXSID4022941 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID4022941 TK.Half.Life NA 111.2 hours 1compartment NA NA Human Human -DTXSID4022941 Css NA 4.482 mg/L 3compartmentss NA 50% Human Human -DTXSID4022941 Css NA 27.43 mg/L 3compartmentss NA 95% Human Human -DTXSID4022941 Css NA 3.12 mg/L PBTK NA 50% Human Human -DTXSID4022941 Css NA 18.3 mg/L PBTK NA 95% Human Human -DTXSID4022941 Clint NA 10.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022941 Fup NA 0.054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022941 Vd NA 2.304 L/kg 1compartment NA NA Rat Human -DTXSID4022941 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID4022941 TK.Half.Life NA 15.78 hours 1compartment NA NA Rat Human -DTXSID4022941 Css NA 2.488 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022941 Css NA 12.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022941 Css NA 1.649 mg/L PBTK NA 50% Rat Human -DTXSID4022941 Css NA 8.086 mg/L PBTK NA 95% Rat Human -DTXSID4022947 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022947 Fup NA 0.0903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022947 Vd NA 0.3478 L/kg 1compartment NA NA Human Human -DTXSID4022947 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4022947 TK.Half.Life NA 24.94 hours 1compartment NA NA Human Human -DTXSID4022947 Css NA 11.09 mg/L 3compartmentss NA 50% Human Human -DTXSID4022947 Css NA 51.85 mg/L 3compartmentss NA 95% Human Human -DTXSID4022947 Css NA 7.021 mg/L PBTK NA 50% Human Human -DTXSID4022947 Css NA 30.97 mg/L PBTK NA 95% Human Human -DTXSID4022947 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022947 Fup NA 0.0903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022947 Vd NA 0.3391 L/kg 1compartment NA NA Rat Human +DTXSID4022868 TK.Half.Life NA 0.8924 hours 1compartment NA NA Rat Human +DTXSID4022868 Css NA 0.001608 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022868 Css NA 0.008984 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022868 Css NA 0.001028 mg/L PBTK NA 50% Rat Human +DTXSID4022868 Css NA 0.005405 mg/L PBTK NA 95% Rat Human +DTXSID4022941 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022941 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022941 Vd NA 3.398 L/kg 1compartment NA NA Human Human +DTXSID4022941 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4022941 TK.Half.Life NA 13.56 hours 1compartment NA NA Human Human +DTXSID4022941 Css NA 0.3586 mg/L 3compartmentss NA 50% Human Human +DTXSID4022941 Css NA 2.385 mg/L 3compartmentss NA 95% Human Human +DTXSID4022941 Css NA 0.2722 mg/L PBTK NA 50% Human Human +DTXSID4022941 Css NA 1.666 mg/L PBTK NA 95% Human Human +DTXSID4022941 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022941 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022941 Vd NA 2.666 L/kg 1compartment NA NA Rat Human +DTXSID4022941 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4022941 TK.Half.Life NA 2.489 hours 1compartment NA NA Rat Human +DTXSID4022941 Css NA 0.046 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022941 Css NA 0.2597 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022941 Css NA 0.03456 mg/L PBTK NA 50% Rat Human +DTXSID4022941 Css NA 0.1866 mg/L PBTK NA 95% Rat Human +DTXSID4022947 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022947 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022947 Vd NA 0.4348 L/kg 1compartment NA NA Human Human +DTXSID4022947 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4022947 TK.Half.Life NA 19.43 hours 1compartment NA NA Human Human +DTXSID4022947 Css NA 5.244 mg/L 3compartmentss NA 50% Human Human +DTXSID4022947 Css NA 24.78 mg/L 3compartmentss NA 95% Human Human +DTXSID4022947 Css NA 3.526 mg/L PBTK NA 50% Human Human +DTXSID4022947 Css NA 14.85 mg/L PBTK NA 95% Human Human +DTXSID4022947 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022947 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022947 Vd NA 0.4252 L/kg 1compartment NA NA Rat Human DTXSID4022947 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022947 TK.Half.Life NA 8.282 hours 1compartment NA NA Rat Human -DTXSID4022947 Css NA 3.128 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022947 Css NA 12.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022947 Css NA 1.861 mg/L PBTK NA 50% Rat Human -DTXSID4022947 Css NA 6.772 mg/L PBTK NA 95% Rat Human +DTXSID4022947 TK.Half.Life NA 6.466 hours 1compartment NA NA Rat Human +DTXSID4022947 Css NA 0.1241 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022947 Css NA 0.8582 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022947 Css NA 0.08284 mg/L PBTK NA 50% Rat Human +DTXSID4022947 Css NA 0.5108 mg/L PBTK NA 95% Rat Human DTXSID4022949 Clint 5.841 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4022949 Fup 0.22 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID4022949 Vd NA 3.715 L/kg 1compartment NA NA Human Human DTXSID4022949 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4022949 TK.Half.Life NA 11.18 hours 1compartment NA NA Human Human -DTXSID4022949 Css NA 0.3063 mg/L 3compartmentss NA 50% Human Human -DTXSID4022949 Css NA 1.77 mg/L 3compartmentss NA 95% Human Human -DTXSID4022949 Css NA 0.1997 mg/L PBTK NA 50% Human Human -DTXSID4022949 Css NA 1.114 mg/L PBTK NA 95% Human Human +DTXSID4022949 Css NA 0.2964 mg/L 3compartmentss NA 50% Human Human +DTXSID4022949 Css NA 1.72 mg/L 3compartmentss NA 95% Human Human +DTXSID4022949 Css NA 0.192 mg/L PBTK NA 50% Human Human +DTXSID4022949 Css NA 1.117 mg/L PBTK NA 95% Human Human DTXSID4022949 Clint 5.841 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID4022949 Fup 0.22 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human DTXSID4022949 Vd NA 3.705 L/kg 1compartment NA NA Rat Human DTXSID4022949 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4022949 TK.Half.Life NA 6.091 hours 1compartment NA NA Rat Human -DTXSID4022949 Css NA 0.159 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022949 Css NA 0.6951 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022949 Css NA 0.0993 mg/L PBTK NA 50% Rat Human -DTXSID4022949 Css NA 0.4082 mg/L PBTK NA 95% Rat Human +DTXSID4022949 Css NA 0.0342 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022949 Css NA 0.142 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022949 Css NA 0.02302 mg/L PBTK NA 50% Rat Human +DTXSID4022949 Css NA 0.09554 mg/L PBTK NA 95% Rat Human DTXSID4022991 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4022991 Fup 0.5653 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4022991 Vd NA 2.975 L/kg 1compartment NA NA Human Human DTXSID4022991 Days.Css NA 36 Days PBTK NA NA Human Human DTXSID4022991 TK.Half.Life NA 182.2 hours 1compartment NA NA Human Human -DTXSID4022991 Css NA 6.578 mg/L 3compartmentss NA 50% Human Human -DTXSID4022991 Css NA 22.32 mg/L 3compartmentss NA 95% Human Human -DTXSID4022991 Css NA 5.13 mg/L PBTK NA 50% Human Human -DTXSID4022991 Css NA 15.13 mg/L PBTK NA 95% Human Human +DTXSID4022991 Css NA 6.062 mg/L 3compartmentss NA 50% Human Human +DTXSID4022991 Css NA 20.62 mg/L 3compartmentss NA 95% Human Human +DTXSID4022991 Css NA 4.738 mg/L PBTK NA 50% Human Human +DTXSID4022991 Css NA 14.18 mg/L PBTK NA 95% Human Human DTXSID4022991 Clint 35.21 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4022991 Fup 0.78 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4022991 Vd NA 2.396 L/kg 1compartment NA NA Rat Rat DTXSID4022991 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID4022991 TK.Half.Life NA 1.154 hours 1compartment NA NA Rat Rat -DTXSID4022991 Css NA 0.0476 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4022991 Css NA 0.2815 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4022991 Css NA 0.03659 mg/L PBTK NA 50% Rat Rat -DTXSID4022991 Css NA 0.2013 mg/L PBTK NA 95% Rat Rat -DTXSID4022993 Clint NA 562.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022993 Fup NA 0.2169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022993 Vd NA 1.813 L/kg 1compartment NA NA Human Human -DTXSID4022993 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4022993 TK.Half.Life NA 1.453 hours 1compartment NA NA Human Human -DTXSID4022993 Css NA 0.005302 mg/L 3compartmentss NA 50% Human Human -DTXSID4022993 Css NA 0.0356 mg/L 3compartmentss NA 95% Human Human -DTXSID4022993 Css NA 0.003866 mg/L PBTK NA 50% Human Human -DTXSID4022993 Css NA 0.02469 mg/L PBTK NA 95% Human Human -DTXSID4022993 Clint NA 562.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022993 Fup NA 0.2169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022993 Vd NA 1.417 L/kg 1compartment NA NA Rat Human -DTXSID4022993 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4022993 TK.Half.Life NA 0.4962 hours 1compartment NA NA Rat Human -DTXSID4022993 Css NA 0.002902 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022993 Css NA 0.01725 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022993 Css NA 0.002031 mg/L PBTK NA 50% Rat Human -DTXSID4022993 Css NA 0.01152 mg/L PBTK NA 95% Rat Human -DTXSID4022999 Clint NA 49.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022999 Fup NA 0.0082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4022999 Vd NA 15.75 L/kg 1compartment NA NA Human Human -DTXSID4022999 Days.Css NA 40 Days PBTK NA NA Human Human -DTXSID4022999 TK.Half.Life NA 210 hours 1compartment NA NA Human Human -DTXSID4022999 Css NA 0.6386 mg/L 3compartmentss NA 50% Human Human -DTXSID4022999 Css NA 3.674 mg/L 3compartmentss NA 95% Human Human -DTXSID4022999 Css NA 1.086 mg/L PBTK NA 50% Human Human -DTXSID4022999 Css NA 5.911 mg/L PBTK NA 95% Human Human -DTXSID4022999 Clint NA 49.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022999 Fup NA 0.0082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4022999 Vd NA 12.65 L/kg 1compartment NA NA Rat Human -DTXSID4022999 Days.Css NA 25 Days PBTK NA NA Rat Human -DTXSID4022999 TK.Half.Life NA 30.75 hours 1compartment NA NA Rat Human -DTXSID4022999 Css NA 0.338 mg/L 3compartmentss NA 50% Rat Human -DTXSID4022999 Css NA 1.498 mg/L 3compartmentss NA 95% Rat Human -DTXSID4022999 Css NA 0.5854 mg/L PBTK NA 50% Rat Human -DTXSID4022999 Css NA 2.481 mg/L PBTK NA 95% Rat Human +DTXSID4022991 Css NA 0.006574 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4022991 Css NA 0.04087 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4022991 Css NA 0.005303 mg/L PBTK NA 50% Rat Rat +DTXSID4022991 Css NA 0.02897 mg/L PBTK NA 95% Rat Rat +DTXSID4022993 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022993 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022993 Vd NA 2.168 L/kg 1compartment NA NA Human Human +DTXSID4022993 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID4022993 TK.Half.Life NA 75.75 hours 1compartment NA NA Human Human +DTXSID4022993 Css NA 3.126 mg/L 3compartmentss NA 50% Human Human +DTXSID4022993 Css NA 10.85 mg/L 3compartmentss NA 95% Human Human +DTXSID4022993 Css NA 2.452 mg/L PBTK NA 50% Human Human +DTXSID4022993 Css NA 7.401 mg/L PBTK NA 95% Human Human +DTXSID4022993 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022993 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022993 Vd NA 1.703 L/kg 1compartment NA NA Rat Human +DTXSID4022993 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4022993 TK.Half.Life NA 13.07 hours 1compartment NA NA Rat Human +DTXSID4022993 Css NA 0.05536 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022993 Css NA 0.3035 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022993 Css NA 0.04178 mg/L PBTK NA 50% Rat Human +DTXSID4022993 Css NA 0.2082 mg/L PBTK NA 95% Rat Human +DTXSID4022995 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022995 Fup 0.59 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4022995 Vd NA 3.093 L/kg 1compartment NA NA Human Human +DTXSID4022995 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4022995 TK.Half.Life NA 3.943 hours 1compartment NA NA Human Human +DTXSID4022995 Css NA 0.07123 mg/L 3compartmentss NA 50% Human Human +DTXSID4022995 Css NA 0.8376 mg/L 3compartmentss NA 95% Human Human +DTXSID4022995 Css NA 0.08607 mg/L PBTK NA 50% Human Human +DTXSID4022995 Css NA 0.6717 mg/L PBTK NA 95% Human Human +DTXSID4022995 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022995 Fup 0.59 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4022995 Vd NA 3.112 L/kg 1compartment NA NA Rat Human +DTXSID4022995 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4022995 TK.Half.Life NA 2.254 hours 1compartment NA NA Rat Human +DTXSID4022995 Css NA 0.007921 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022995 Css NA 0.08113 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022995 Css NA 0.01001 mg/L PBTK NA 50% Rat Human +DTXSID4022995 Css NA 0.06153 mg/L PBTK NA 95% Rat Human +DTXSID4022999 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022999 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4022999 Vd NA 26.71 L/kg 1compartment NA NA Human Human +DTXSID4022999 Days.Css NA 188 Days PBTK NA NA Human Human +DTXSID4022999 TK.Half.Life NA 792.9 hours 1compartment NA NA Human Human +DTXSID4022999 Css NA 0.8462 mg/L 3compartmentss NA 50% Human Human +DTXSID4022999 Css NA 5.256 mg/L 3compartmentss NA 95% Human Human +DTXSID4022999 Css NA 2.386 mg/L PBTK NA 50% Human Human +DTXSID4022999 Css NA 14.24 mg/L PBTK NA 95% Human Human +DTXSID4022999 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022999 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4022999 Vd NA 21.96 L/kg 1compartment NA NA Rat Human +DTXSID4022999 Days.Css NA 115 Days PBTK NA NA Rat Human +DTXSID4022999 TK.Half.Life NA 114 hours 1compartment NA NA Rat Human +DTXSID4022999 Css NA 0.1011 mg/L 3compartmentss NA 50% Rat Human +DTXSID4022999 Css NA 0.4687 mg/L 3compartmentss NA 95% Rat Human +DTXSID4022999 Css NA 0.3082 mg/L PBTK NA 50% Rat Human +DTXSID4022999 Css NA 1.517 mg/L PBTK NA 95% Rat Human DTXSID4023042 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4023042 Fup 0.07 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID4023042 Vd NA 2.719 L/kg 1compartment NA NA Human Human -DTXSID4023042 Days.Css NA 301 Days PBTK NA NA Human Human -DTXSID4023042 TK.Half.Life NA 1171 hours 1compartment NA NA Human Human -DTXSID4023042 Css NA 61.3 mg/L 3compartmentss NA 50% Human Human -DTXSID4023042 Css NA 169.4 mg/L 3compartmentss NA 95% Human Human -DTXSID4023042 Css NA 37.21 mg/L PBTK NA 50% Human Human -DTXSID4023042 Css NA 100.3 mg/L PBTK NA 95% Human Human +DTXSID4023042 Vd NA 2.787 L/kg 1compartment NA NA Human Human +DTXSID4023042 Days.Css NA 370 Days PBTK NA NA Human Human +DTXSID4023042 TK.Half.Life NA 1422 hours 1compartment NA NA Human Human +DTXSID4023042 Css NA 59.82 mg/L 3compartmentss NA 50% Human Human +DTXSID4023042 Css NA 163.4 mg/L 3compartmentss NA 95% Human Human +DTXSID4023042 Css NA 41.88 mg/L PBTK NA 50% Human Human +DTXSID4023042 Css NA 114.4 mg/L PBTK NA 95% Human Human DTXSID4023042 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4023042 Fup 0.01 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID4023042 Vd NA 1.181 L/kg 1compartment NA NA Rat Rat -DTXSID4023042 Days.Css NA 101 Days PBTK NA NA Rat Rat -DTXSID4023042 TK.Half.Life NA 292.8 hours 1compartment NA NA Rat Rat -DTXSID4023042 Css NA 40.63 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4023042 Css NA 185 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4023042 Css NA 25.08 mg/L PBTK NA 50% Rat Rat -DTXSID4023042 Css NA 103.4 mg/L PBTK NA 95% Rat Rat -DTXSID4023044 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023044 Fup NA 0.2169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023044 Vd NA 3.709 L/kg 1compartment NA NA Human Human +DTXSID4023042 Vd NA 1.282 L/kg 1compartment NA NA Rat Rat +DTXSID4023042 Days.Css NA 120 Days PBTK NA NA Rat Rat +DTXSID4023042 TK.Half.Life NA 326.2 hours 1compartment NA NA Rat Rat +DTXSID4023042 Css NA 8.578 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4023042 Css NA 32.87 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4023042 Css NA 6.216 mg/L PBTK NA 50% Rat Rat +DTXSID4023042 Css NA 23.82 mg/L PBTK NA 95% Rat Rat +DTXSID4023044 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023044 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023044 Vd NA 2.931 L/kg 1compartment NA NA Human Human DTXSID4023044 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023044 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human -DTXSID4023044 Css NA 0.08586 mg/L 3compartmentss NA 50% Human Human -DTXSID4023044 Css NA 0.6371 mg/L 3compartmentss NA 95% Human Human -DTXSID4023044 Css NA 0.1026 mg/L PBTK NA 50% Human Human -DTXSID4023044 Css NA 0.6103 mg/L PBTK NA 95% Human Human -DTXSID4023044 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023044 Fup NA 0.2169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023044 Vd NA 3.741 L/kg 1compartment NA NA Rat Human +DTXSID4023044 TK.Half.Life NA 3.912 hours 1compartment NA NA Human Human +DTXSID4023044 Css NA 0.07808 mg/L 3compartmentss NA 50% Human Human +DTXSID4023044 Css NA 0.761 mg/L 3compartmentss NA 95% Human Human +DTXSID4023044 Css NA 0.07704 mg/L PBTK NA 50% Human Human +DTXSID4023044 Css NA 0.6159 mg/L PBTK NA 95% Human Human +DTXSID4023044 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023044 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023044 Vd NA 2.938 L/kg 1compartment NA NA Rat Human DTXSID4023044 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023044 TK.Half.Life NA 3.42 hours 1compartment NA NA Rat Human -DTXSID4023044 Css NA 0.04369 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023044 Css NA 0.2719 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023044 Css NA 0.0522 mg/L PBTK NA 50% Rat Human -DTXSID4023044 Css NA 0.2446 mg/L PBTK NA 95% Rat Human -DTXSID4023094 Clint NA 12.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023094 Fup NA 0.1032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023094 Vd NA 1.849 L/kg 1compartment NA NA Human Human +DTXSID4023044 TK.Half.Life NA 2.251 hours 1compartment NA NA Rat Human +DTXSID4023044 Css NA 0.009822 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023044 Css NA 0.07514 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023044 Css NA 0.00994 mg/L PBTK NA 50% Rat Human +DTXSID4023044 Css NA 0.05893 mg/L PBTK NA 95% Rat Human +DTXSID4023046 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023046 Fup 0.53 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4023046 Vd NA 4.215 L/kg 1compartment NA NA Human Human +DTXSID4023046 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023046 TK.Half.Life NA 5.714 hours 1compartment NA NA Human Human +DTXSID4023046 Css NA 0.0591 mg/L 3compartmentss NA 50% Human Human +DTXSID4023046 Css NA 0.6111 mg/L 3compartmentss NA 95% Human Human +DTXSID4023046 Css NA 0.08048 mg/L PBTK NA 50% Human Human +DTXSID4023046 Css NA 0.5535 mg/L PBTK NA 95% Human Human +DTXSID4023046 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023046 Fup 0.53 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4023046 Vd NA 4.291 L/kg 1compartment NA NA Rat Human +DTXSID4023046 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023046 TK.Half.Life NA 3.279 hours 1compartment NA NA Rat Human +DTXSID4023046 Css NA 0.002516 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023046 Css NA 0.0297 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023046 Css NA 0.003613 mg/L PBTK NA 50% Rat Human +DTXSID4023046 Css NA 0.02671 mg/L PBTK NA 95% Rat Human +DTXSID4023048 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023048 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023048 Vd NA 2.604 L/kg 1compartment NA NA Human Human +DTXSID4023048 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023048 TK.Half.Life NA 4.016 hours 1compartment NA NA Human Human +DTXSID4023048 Css NA 0.09312 mg/L 3compartmentss NA 50% Human Human +DTXSID4023048 Css NA 0.8299 mg/L 3compartmentss NA 95% Human Human +DTXSID4023048 Css NA 0.09893 mg/L PBTK NA 50% Human Human +DTXSID4023048 Css NA 0.6597 mg/L PBTK NA 95% Human Human +DTXSID4023048 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023048 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023048 Vd NA 2.637 L/kg 1compartment NA NA Rat Human +DTXSID4023048 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023048 TK.Half.Life NA 2.302 hours 1compartment NA NA Rat Human +DTXSID4023048 Css NA 0.01056 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023048 Css NA 0.07662 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023048 Css NA 0.01155 mg/L PBTK NA 50% Rat Human +DTXSID4023048 Css NA 0.05767 mg/L PBTK NA 95% Rat Human +DTXSID4023094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023094 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023094 Vd NA 1.681 L/kg 1compartment NA NA Human Human DTXSID4023094 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023094 TK.Half.Life NA 8.683 hours 1compartment NA NA Human Human -DTXSID4023094 Css NA 0.584 mg/L 3compartmentss NA 50% Human Human -DTXSID4023094 Css NA 4.008 mg/L 3compartmentss NA 95% Human Human -DTXSID4023094 Css NA 0.3925 mg/L PBTK NA 50% Human Human -DTXSID4023094 Css NA 2.565 mg/L PBTK NA 95% Human Human -DTXSID4023094 Clint NA 12.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023094 Fup NA 0.1032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023094 Vd NA 1.405 L/kg 1compartment NA NA Rat Human +DTXSID4023094 TK.Half.Life NA 4.738 hours 1compartment NA NA Human Human +DTXSID4023094 Css NA 0.2992 mg/L 3compartmentss NA 50% Human Human +DTXSID4023094 Css NA 2.132 mg/L 3compartmentss NA 95% Human Human +DTXSID4023094 Css NA 0.2005 mg/L PBTK NA 50% Human Human +DTXSID4023094 Css NA 1.343 mg/L PBTK NA 95% Human Human +DTXSID4023094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023094 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023094 Vd NA 1.283 L/kg 1compartment NA NA Rat Human DTXSID4023094 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023094 TK.Half.Life NA 3.022 hours 1compartment NA NA Rat Human -DTXSID4023094 Css NA 0.3242 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023094 Css NA 1.623 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023094 Css NA 0.2072 mg/L PBTK NA 50% Rat Human -DTXSID4023094 Css NA 0.9809 mg/L PBTK NA 95% Rat Human -DTXSID4023096 Clint NA 63.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023096 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023096 Vd NA 0.1813 L/kg 1compartment NA NA Human Human -DTXSID4023096 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023096 TK.Half.Life NA 0.7543 hours 1compartment NA NA Human Human -DTXSID4023096 Css NA 0.6281 mg/L 3compartmentss NA 50% Human Human -DTXSID4023096 Css NA 6.528 mg/L 3compartmentss NA 95% Human Human -DTXSID4023096 Css NA 0.3657 mg/L PBTK NA 50% Human Human -DTXSID4023096 Css NA 3.812 mg/L PBTK NA 95% Human Human -DTXSID4023096 Clint NA 63.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023096 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023096 Vd NA 0.1779 L/kg 1compartment NA NA Rat Human +DTXSID4023094 TK.Half.Life NA 1.749 hours 1compartment NA NA Rat Human +DTXSID4023094 Css NA 0.03824 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023094 Css NA 0.2245 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023094 Css NA 0.02522 mg/L PBTK NA 50% Rat Human +DTXSID4023094 Css NA 0.1428 mg/L PBTK NA 95% Rat Human +DTXSID4023096 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023096 Fup 0.0287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023096 Vd NA 1.787 L/kg 1compartment NA NA Human Human +DTXSID4023096 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4023096 TK.Half.Life NA 13.48 hours 1compartment NA NA Human Human +DTXSID4023096 Css NA 0.9663 mg/L 3compartmentss NA 50% Human Human +DTXSID4023096 Css NA 8.212 mg/L 3compartmentss NA 95% Human Human +DTXSID4023096 Css NA 0.6183 mg/L PBTK NA 50% Human Human +DTXSID4023096 Css NA 5.042 mg/L PBTK NA 95% Human Human +DTXSID4023096 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023096 Fup 0.0287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023096 Vd NA 1.33 L/kg 1compartment NA NA Rat Human DTXSID4023096 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023096 TK.Half.Life NA 0.469 hours 1compartment NA NA Rat Human -DTXSID4023096 Css NA 0.3587 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023096 Css NA 2.895 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023096 Css NA 0.1957 mg/L PBTK NA 50% Rat Human -DTXSID4023096 Css NA 1.567 mg/L PBTK NA 95% Rat Human -DTXSID4023123 Clint NA 0.7176 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023123 Fup NA 0.9174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023123 Vd NA 11.39 L/kg 1compartment NA NA Human Human -DTXSID4023123 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4023123 TK.Half.Life NA 22.97 hours 1compartment NA NA Human Human -DTXSID4023123 Css NA 0.05075 mg/L 3compartmentss NA 50% Human Human -DTXSID4023123 Css NA 0.3484 mg/L 3compartmentss NA 95% Human Human -DTXSID4023123 Css NA 0.1755 mg/L PBTK NA 50% Human Human -DTXSID4023123 Css NA 0.7684 mg/L PBTK NA 95% Human Human -DTXSID4023123 Clint NA 0.7176 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023123 Fup NA 0.9174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023123 Vd NA 11.42 L/kg 1compartment NA NA Rat Human -DTXSID4023123 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4023123 TK.Half.Life NA 9.327 hours 1compartment NA NA Rat Human -DTXSID4023123 Css NA 0.02158 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023123 Css NA 0.1186 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023123 Css NA 0.08 mg/L PBTK NA 50% Rat Human -DTXSID4023123 Css NA 0.2466 mg/L PBTK NA 95% Rat Human -DTXSID4023125 Clint NA 2.017 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023125 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023125 Vd NA 1.284 L/kg 1compartment NA NA Human Human +DTXSID4023096 TK.Half.Life NA 4.712 hours 1compartment NA NA Rat Human +DTXSID4023096 Css NA 0.04888 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023096 Css NA 0.4414 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023096 Css NA 0.03056 mg/L PBTK NA 50% Rat Human +DTXSID4023096 Css NA 0.2595 mg/L PBTK NA 95% Rat Human +DTXSID4023123 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023123 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023123 Vd NA 1.291 L/kg 1compartment NA NA Human Human +DTXSID4023123 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023123 TK.Half.Life NA 2.9 hours 1compartment NA NA Human Human +DTXSID4023123 Css NA 0.1702 mg/L 3compartmentss NA 50% Human Human +DTXSID4023123 Css NA 1.183 mg/L 3compartmentss NA 95% Human Human +DTXSID4023123 Css NA 0.143 mg/L PBTK NA 50% Human Human +DTXSID4023123 Css NA 0.8476 mg/L PBTK NA 95% Human Human +DTXSID4023123 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023123 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023123 Vd NA 1.273 L/kg 1compartment NA NA Rat Human +DTXSID4023123 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023123 TK.Half.Life NA 1.648 hours 1compartment NA NA Rat Human +DTXSID4023123 Css NA 0.02006 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023123 Css NA 0.09855 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023123 Css NA 0.01682 mg/L PBTK NA 50% Rat Human +DTXSID4023123 Css NA 0.06838 mg/L PBTK NA 95% Rat Human +DTXSID4023125 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023125 Fup 0.815 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023125 Vd NA 1.123 L/kg 1compartment NA NA Human Human DTXSID4023125 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023125 TK.Half.Life NA 2.307 hours 1compartment NA NA Human Human -DTXSID4023125 Css NA 0.1829 mg/L 3compartmentss NA 50% Human Human -DTXSID4023125 Css NA 1.403 mg/L 3compartmentss NA 95% Human Human -DTXSID4023125 Css NA 0.1654 mg/L PBTK NA 50% Human Human -DTXSID4023125 Css NA 1.013 mg/L PBTK NA 95% Human Human -DTXSID4023125 Clint NA 2.017 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023125 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023125 Vd NA 1.288 L/kg 1compartment NA NA Rat Human +DTXSID4023125 TK.Half.Life NA 8.914 hours 1compartment NA NA Human Human +DTXSID4023125 Css NA 0.8861 mg/L 3compartmentss NA 50% Human Human +DTXSID4023125 Css NA 5.723 mg/L 3compartmentss NA 95% Human Human +DTXSID4023125 Css NA 0.7812 mg/L PBTK NA 50% Human Human +DTXSID4023125 Css NA 3.831 mg/L PBTK NA 95% Human Human +DTXSID4023125 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023125 Fup 0.815 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023125 Vd NA 1.124 L/kg 1compartment NA NA Rat Human DTXSID4023125 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023125 TK.Half.Life NA 1.195 hours 1compartment NA NA Rat Human -DTXSID4023125 Css NA 0.07522 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023125 Css NA 0.5077 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023125 Css NA 0.06851 mg/L PBTK NA 50% Rat Human -DTXSID4023125 Css NA 0.3224 mg/L PBTK NA 95% Rat Human -DTXSID4023171 Clint NA 1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023171 Fup NA 0.2238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023171 Vd NA 0.7808 L/kg 1compartment NA NA Human Human +DTXSID4023125 TK.Half.Life NA 3.041 hours 1compartment NA NA Rat Human +DTXSID4023125 Css NA 0.05241 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023125 Css NA 0.3387 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023125 Css NA 0.04648 mg/L PBTK NA 50% Rat Human +DTXSID4023125 Css NA 0.213 mg/L PBTK NA 95% Rat Human +DTXSID4023129 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023129 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4023129 Vd NA 0.6447 L/kg 1compartment NA NA Human Human +DTXSID4023129 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023129 TK.Half.Life NA 3.504 hours 1compartment NA NA Human Human +DTXSID4023129 Css NA 0.7153 mg/L 3compartmentss NA 50% Human Human +DTXSID4023129 Css NA 5.042 mg/L 3compartmentss NA 95% Human Human +DTXSID4023129 Css NA 0.4629 mg/L PBTK NA 50% Human Human +DTXSID4023129 Css NA 3.078 mg/L PBTK NA 95% Human Human +DTXSID4023129 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023129 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4023129 Vd NA 0.6248 L/kg 1compartment NA NA Rat Human +DTXSID4023129 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023129 TK.Half.Life NA 2.053 hours 1compartment NA NA Rat Human +DTXSID4023129 Css NA 0.08507 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023129 Css NA 0.4481 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023129 Css NA 0.05397 mg/L PBTK NA 50% Rat Human +DTXSID4023129 Css NA 0.2646 mg/L PBTK NA 95% Rat Human +DTXSID4023171 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023171 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023171 Vd NA 0.9035 L/kg 1compartment NA NA Human Human DTXSID4023171 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023171 TK.Half.Life NA 8.97 hours 1compartment NA NA Human Human -DTXSID4023171 Css NA 1.322 mg/L 3compartmentss NA 50% Human Human -DTXSID4023171 Css NA 5.688 mg/L 3compartmentss NA 95% Human Human -DTXSID4023171 Css NA 0.931 mg/L PBTK NA 50% Human Human -DTXSID4023171 Css NA 3.596 mg/L PBTK NA 95% Human Human -DTXSID4023171 Clint NA 1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023171 Fup NA 0.2238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023171 Vd NA 0.6794 L/kg 1compartment NA NA Rat Human +DTXSID4023171 TK.Half.Life NA 2.389 hours 1compartment NA NA Human Human +DTXSID4023171 Css NA 0.2314 mg/L 3compartmentss NA 50% Human Human +DTXSID4023171 Css NA 1.445 mg/L 3compartmentss NA 95% Human Human +DTXSID4023171 Css NA 0.1685 mg/L PBTK NA 50% Human Human +DTXSID4023171 Css NA 0.9654 mg/L PBTK NA 95% Human Human +DTXSID4023171 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023171 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023171 Vd NA 0.7877 L/kg 1compartment NA NA Rat Human DTXSID4023171 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023171 TK.Half.Life NA 3.743 hours 1compartment NA NA Rat Human -DTXSID4023171 Css NA 0.5421 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023171 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023171 Css NA 0.3624 mg/L PBTK NA 50% Rat Human -DTXSID4023171 Css NA 1.085 mg/L PBTK NA 95% Rat Human -DTXSID4023175 Clint NA 0.2618 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4023171 TK.Half.Life NA 1.157 hours 1compartment NA NA Rat Human +DTXSID4023171 Css NA 0.02768 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023171 Css NA 0.1252 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023171 Css NA 0.02005 mg/L PBTK NA 50% Rat Human +DTXSID4023171 Css NA 0.08138 mg/L PBTK NA 95% Rat Human +DTXSID4023175 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4023175 Fup 0.71 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4023175 Vd NA 2.649 L/kg 1compartment NA NA Human Human -DTXSID4023175 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4023175 TK.Half.Life NA 16.91 hours 1compartment NA NA Human Human -DTXSID4023175 Css NA 0.533 mg/L 3compartmentss NA 50% Human Human -DTXSID4023175 Css NA 4.09 mg/L 3compartmentss NA 95% Human Human -DTXSID4023175 Css NA 0.5998 mg/L PBTK NA 50% Human Human -DTXSID4023175 Css NA 2.912 mg/L PBTK NA 95% Human Human -DTXSID4023175 Clint NA 0.2618 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4023175 Vd NA 2.959 L/kg 1compartment NA NA Human Human +DTXSID4023175 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4023175 TK.Half.Life NA 27 hours 1compartment NA NA Human Human +DTXSID4023175 Css NA 0.645 mg/L 3compartmentss NA 50% Human Human +DTXSID4023175 Css NA 5.354 mg/L 3compartmentss NA 95% Human Human +DTXSID4023175 Css NA 0.7572 mg/L PBTK NA 50% Human Human +DTXSID4023175 Css NA 3.879 mg/L PBTK NA 95% Human Human +DTXSID4023175 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4023175 Fup 0.71 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4023175 Vd NA 2.687 L/kg 1compartment NA NA Rat Human +DTXSID4023175 Vd NA 3.006 L/kg 1compartment NA NA Rat Human DTXSID4023175 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023175 TK.Half.Life NA 6.904 hours 1compartment NA NA Rat Human -DTXSID4023175 Css NA 0.1619 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023175 Css NA 1.347 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023175 Css NA 0.18 mg/L PBTK NA 50% Rat Human -DTXSID4023175 Css NA 0.8869 mg/L PBTK NA 95% Rat Human +DTXSID4023175 TK.Half.Life NA 9.339 hours 1compartment NA NA Rat Human +DTXSID4023175 Css NA 0.01634 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023175 Css NA 0.1552 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023175 Css NA 0.01872 mg/L PBTK NA 50% Rat Human +DTXSID4023175 Css NA 0.119 mg/L PBTK NA 95% Rat Human +DTXSID4023177 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023177 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023177 Vd NA 4.962 L/kg 1compartment NA NA Human Human +DTXSID4023177 Days.Css NA 23 Days PBTK NA NA Human Human +DTXSID4023177 TK.Half.Life NA 133.2 hours 1compartment NA NA Human Human +DTXSID4023177 Css NA 2.746 mg/L 3compartmentss NA 50% Human Human +DTXSID4023177 Css NA 18.52 mg/L 3compartmentss NA 95% Human Human +DTXSID4023177 Css NA 2.21 mg/L PBTK NA 50% Human Human +DTXSID4023177 Css NA 14.15 mg/L PBTK NA 95% Human Human +DTXSID4023177 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023177 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023177 Vd NA 3.787 L/kg 1compartment NA NA Rat Human +DTXSID4023177 Days.Css NA 14 Days PBTK NA NA Rat Human +DTXSID4023177 TK.Half.Life NA 18.47 hours 1compartment NA NA Rat Human +DTXSID4023177 Css NA 0.3538 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023177 Css NA 1.949 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023177 Css NA 0.2861 mg/L PBTK NA 50% Rat Human +DTXSID4023177 Css NA 1.499 mg/L PBTK NA 95% Rat Human DTXSID4023179 Clint 18 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID4023179 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4023179 Vd NA 2.832 L/kg 1compartment NA NA Human Human +DTXSID4023179 Vd NA 2.833 L/kg 1compartment NA NA Human Human DTXSID4023179 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4023179 TK.Half.Life NA 38.83 hours 1compartment NA NA Human Human -DTXSID4023179 Css NA 1.861 mg/L 3compartmentss NA 50% Human Human -DTXSID4023179 Css NA 11.55 mg/L 3compartmentss NA 95% Human Human -DTXSID4023179 Css NA 1.077 mg/L PBTK NA 50% Human Human -DTXSID4023179 Css NA 6.669 mg/L PBTK NA 95% Human Human +DTXSID4023179 TK.Half.Life NA 38.85 hours 1compartment NA NA Human Human +DTXSID4023179 Css NA 2.132 mg/L 3compartmentss NA 50% Human Human +DTXSID4023179 Css NA 13.94 mg/L 3compartmentss NA 95% Human Human +DTXSID4023179 Css NA 1.172 mg/L PBTK NA 50% Human Human +DTXSID4023179 Css NA 7.665 mg/L PBTK NA 95% Human Human DTXSID4023179 Clint 18 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID4023179 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4023179 Vd NA 2.122 L/kg 1compartment NA NA Rat Human DTXSID4023179 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID4023179 TK.Half.Life NA 7.543 hours 1compartment NA NA Rat Human -DTXSID4023179 Css NA 1.194 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023179 Css NA 5.985 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023179 Css NA 0.6428 mg/L PBTK NA 50% Rat Human -DTXSID4023179 Css NA 3.221 mg/L PBTK NA 95% Rat Human -DTXSID4023200 Clint NA 163.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4023179 Css NA 0.2633 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023179 Css NA 1.422 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023179 Css NA 0.1499 mg/L PBTK NA 50% Rat Human +DTXSID4023179 Css NA 0.8095 mg/L PBTK NA 95% Rat Human +DTXSID4023200 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4023200 Fup 0.021 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4023200 Vd NA 0.9126 L/kg 1compartment NA NA Human Human -DTXSID4023200 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023200 TK.Half.Life NA 1.839 hours 1compartment NA NA Human Human -DTXSID4023200 Css NA 0.2 mg/L 3compartmentss NA 50% Human Human -DTXSID4023200 Css NA 2.008 mg/L 3compartmentss NA 95% Human Human -DTXSID4023200 Css NA 0.1156 mg/L PBTK NA 50% Human Human -DTXSID4023200 Css NA 1.165 mg/L PBTK NA 95% Human Human -DTXSID4023200 Clint NA 163.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4023200 Vd NA 0.9528 L/kg 1compartment NA NA Human Human +DTXSID4023200 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4023200 TK.Half.Life NA 24.74 hours 1compartment NA NA Human Human +DTXSID4023200 Css NA 4.816 mg/L 3compartmentss NA 50% Human Human +DTXSID4023200 Css NA 39.48 mg/L 3compartmentss NA 95% Human Human +DTXSID4023200 Css NA 2.697 mg/L PBTK NA 50% Human Human +DTXSID4023200 Css NA 22.11 mg/L PBTK NA 95% Human Human +DTXSID4023200 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4023200 Fup 0.021 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4023200 Vd NA 0.6833 L/kg 1compartment NA NA Rat Human -DTXSID4023200 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023200 TK.Half.Life NA 0.7381 hours 1compartment NA NA Rat Human -DTXSID4023200 Css NA 0.1165 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023200 Css NA 0.8777 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023200 Css NA 0.0629 mg/L PBTK NA 50% Rat Human -DTXSID4023200 Css NA 0.4739 mg/L PBTK NA 95% Rat Human -DTXSID4023202 Clint NA 1.132 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4023200 Vd NA 0.7121 L/kg 1compartment NA NA Rat Human +DTXSID4023200 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4023200 TK.Half.Life NA 10.7 hours 1compartment NA NA Rat Human +DTXSID4023200 Css NA 0.5632 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023200 Css NA 3.49 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023200 Css NA 0.3265 mg/L PBTK NA 50% Rat Human +DTXSID4023200 Css NA 2.024 mg/L PBTK NA 95% Rat Human +DTXSID4023202 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4023202 Fup 0.41 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4023202 Vd NA 1.821 L/kg 1compartment NA NA Human Human -DTXSID4023202 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4023202 TK.Half.Life NA 14.17 hours 1compartment NA NA Human Human -DTXSID4023202 Css NA 0.7948 mg/L 3compartmentss NA 50% Human Human -DTXSID4023202 Css NA 3.519 mg/L 3compartmentss NA 95% Human Human -DTXSID4023202 Css NA 0.6486 mg/L PBTK NA 50% Human Human -DTXSID4023202 Css NA 2.424 mg/L PBTK NA 95% Human Human -DTXSID4023202 Clint NA 1.132 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4023202 Vd NA 2.235 L/kg 1compartment NA NA Human Human +DTXSID4023202 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID4023202 TK.Half.Life NA 68.63 hours 1compartment NA NA Human Human +DTXSID4023202 Css NA 2.682 mg/L 3compartmentss NA 50% Human Human +DTXSID4023202 Css NA 8.273 mg/L 3compartmentss NA 95% Human Human +DTXSID4023202 Css NA 2.468 mg/L PBTK NA 50% Human Human +DTXSID4023202 Css NA 7.611 mg/L PBTK NA 95% Human Human +DTXSID4023202 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4023202 Fup 0.41 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4023202 Vd NA 1.47 L/kg 1compartment NA NA Rat Human -DTXSID4023202 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023202 TK.Half.Life NA 4.486 hours 1compartment NA NA Rat Human -DTXSID4023202 Css NA 0.3252 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023202 Css NA 1.152 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023202 Css NA 0.2566 mg/L PBTK NA 50% Rat Human -DTXSID4023202 Css NA 0.7363 mg/L PBTK NA 95% Rat Human -DTXSID4023252 Clint NA 1.403 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023252 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023252 Vd NA 2.91 L/kg 1compartment NA NA Human Human -DTXSID4023252 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4023252 TK.Half.Life NA 23.66 hours 1compartment NA NA Human Human -DTXSID4023252 Css NA 0.8036 mg/L 3compartmentss NA 50% Human Human -DTXSID4023252 Css NA 4.326 mg/L 3compartmentss NA 95% Human Human -DTXSID4023252 Css NA 0.6788 mg/L PBTK NA 50% Human Human -DTXSID4023252 Css NA 3.072 mg/L PBTK NA 95% Human Human -DTXSID4023252 Clint NA 1.403 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023252 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023252 Vd NA 2.272 L/kg 1compartment NA NA Rat Human -DTXSID4023252 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4023252 TK.Half.Life NA 4.151 hours 1compartment NA NA Rat Human -DTXSID4023252 Css NA 0.3342 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023252 Css NA 1.314 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023252 Css NA 0.2758 mg/L PBTK NA 50% Rat Human -DTXSID4023252 Css NA 0.87 mg/L PBTK NA 95% Rat Human -DTXSID4023254 Clint NA 50.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023254 Fup NA 0.4364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023254 Vd NA 1.074 L/kg 1compartment NA NA Human Human +DTXSID4023202 Vd NA 1.76 L/kg 1compartment NA NA Rat Human +DTXSID4023202 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4023202 TK.Half.Life NA 11.6 hours 1compartment NA NA Rat Human +DTXSID4023202 Css NA 0.1622 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023202 Css NA 0.4076 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023202 Css NA 0.1545 mg/L PBTK NA 50% Rat Human +DTXSID4023202 Css NA 0.3883 mg/L PBTK NA 95% Rat Human +DTXSID4023252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023252 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023252 Vd NA 0.4409 L/kg 1compartment NA NA Human Human +DTXSID4023252 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023252 TK.Half.Life NA 0.7379 hours 1compartment NA NA Human Human +DTXSID4023252 Css NA 0.1106 mg/L 3compartmentss NA 50% Human Human +DTXSID4023252 Css NA 0.7743 mg/L 3compartmentss NA 95% Human Human +DTXSID4023252 Css NA 0.0727 mg/L PBTK NA 50% Human Human +DTXSID4023252 Css NA 0.485 mg/L PBTK NA 95% Human Human +DTXSID4023252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023252 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023252 Vd NA 0.4196 L/kg 1compartment NA NA Rat Human +DTXSID4023252 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023252 TK.Half.Life NA 0.3872 hours 1compartment NA NA Rat Human +DTXSID4023252 Css NA 0.014 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023252 Css NA 0.07488 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023252 Css NA 0.009082 mg/L PBTK NA 50% Rat Human +DTXSID4023252 Css NA 0.0463 mg/L PBTK NA 95% Rat Human +DTXSID4023254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023254 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023254 Vd NA 1.113 L/kg 1compartment NA NA Human Human DTXSID4023254 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023254 TK.Half.Life NA 0.9035 hours 1compartment NA NA Human Human -DTXSID4023254 Css NA 0.0209 mg/L 3compartmentss NA 50% Human Human -DTXSID4023254 Css NA 0.1638 mg/L 3compartmentss NA 95% Human Human -DTXSID4023254 Css NA 0.0165 mg/L PBTK NA 50% Human Human -DTXSID4023254 Css NA 0.116 mg/L PBTK NA 95% Human Human -DTXSID4023254 Clint NA 50.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023254 Fup NA 0.4364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023254 Vd NA 0.9498 L/kg 1compartment NA NA Rat Human +DTXSID4023254 TK.Half.Life NA 1.139 hours 1compartment NA NA Human Human +DTXSID4023254 Css NA 0.04176 mg/L 3compartmentss NA 50% Human Human +DTXSID4023254 Css NA 0.3643 mg/L 3compartmentss NA 95% Human Human +DTXSID4023254 Css NA 0.0337 mg/L PBTK NA 50% Human Human +DTXSID4023254 Css NA 0.2541 mg/L PBTK NA 95% Human Human +DTXSID4023254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023254 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023254 Vd NA 0.9855 L/kg 1compartment NA NA Rat Human DTXSID4023254 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023254 TK.Half.Life NA 0.3775 hours 1compartment NA NA Rat Human -DTXSID4023254 Css NA 0.01124 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023254 Css NA 0.07462 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023254 Css NA 0.008598 mg/L PBTK NA 50% Rat Human -DTXSID4023254 Css NA 0.05071 mg/L PBTK NA 95% Rat Human -DTXSID4023258 Clint NA 2.818 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023258 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023258 Vd NA 0.852 L/kg 1compartment NA NA Human Human +DTXSID4023254 TK.Half.Life NA 0.5041 hours 1compartment NA NA Rat Human +DTXSID4023254 Css NA 0.005048 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023254 Css NA 0.03575 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023254 Css NA 0.004112 mg/L PBTK NA 50% Rat Human +DTXSID4023254 Css NA 0.02487 mg/L PBTK NA 95% Rat Human +DTXSID4023258 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023258 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023258 Vd NA 1.113 L/kg 1compartment NA NA Human Human DTXSID4023258 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023258 TK.Half.Life NA 6.57 hours 1compartment NA NA Human Human -DTXSID4023258 Css NA 0.949 mg/L 3compartmentss NA 50% Human Human -DTXSID4023258 Css NA 5.055 mg/L 3compartmentss NA 95% Human Human -DTXSID4023258 Css NA 0.6444 mg/L PBTK NA 50% Human Human -DTXSID4023258 Css NA 3.186 mg/L PBTK NA 95% Human Human -DTXSID4023258 Clint NA 2.818 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023258 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023258 Vd NA 0.7075 L/kg 1compartment NA NA Rat Human +DTXSID4023258 TK.Half.Life NA 1.564 hours 1compartment NA NA Human Human +DTXSID4023258 Css NA 0.07942 mg/L 3compartmentss NA 50% Human Human +DTXSID4023258 Css NA 0.5691 mg/L 3compartmentss NA 95% Human Human +DTXSID4023258 Css NA 0.0578 mg/L PBTK NA 50% Human Human +DTXSID4023258 Css NA 0.3892 mg/L PBTK NA 95% Human Human +DTXSID4023258 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023258 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023258 Vd NA 0.928 L/kg 1compartment NA NA Rat Human DTXSID4023258 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023258 TK.Half.Life NA 2.969 hours 1compartment NA NA Rat Human -DTXSID4023258 Css NA 0.4572 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023258 Css NA 1.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023258 Css NA 0.2925 mg/L PBTK NA 50% Rat Human -DTXSID4023258 Css NA 1.036 mg/L PBTK NA 95% Rat Human -DTXSID4023333 Clint NA 14.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4023258 TK.Half.Life NA 0.673 hours 1compartment NA NA Rat Human +DTXSID4023258 Css NA 0.01002 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023258 Css NA 0.0551 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023258 Css NA 0.00731 mg/L PBTK NA 50% Rat Human +DTXSID4023258 Css NA 0.03659 mg/L PBTK NA 95% Rat Human +DTXSID4023333 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4023333 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4023333 Vd NA 1.638 L/kg 1compartment NA NA Human Human -DTXSID4023333 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4023333 TK.Half.Life NA 36.06 hours 1compartment NA NA Human Human -DTXSID4023333 Css NA 3.681 mg/L 3compartmentss NA 50% Human Human -DTXSID4023333 Css NA 31.4 mg/L 3compartmentss NA 95% Human Human -DTXSID4023333 Css NA 2.304 mg/L PBTK NA 50% Human Human -DTXSID4023333 Css NA 18.97 mg/L PBTK NA 95% Human Human -DTXSID4023333 Clint NA 14.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4023333 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4023333 TK.Half.Life NA 24.68 hours 1compartment NA NA Human Human +DTXSID4023333 Css NA 2.393 mg/L 3compartmentss NA 50% Human Human +DTXSID4023333 Css NA 21.48 mg/L 3compartmentss NA 95% Human Human +DTXSID4023333 Css NA 1.508 mg/L PBTK NA 50% Human Human +DTXSID4023333 Css NA 12.93 mg/L PBTK NA 95% Human Human +DTXSID4023333 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4023333 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4023333 Vd NA 1.213 L/kg 1compartment NA NA Rat Human -DTXSID4023333 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4023333 TK.Half.Life NA 13.31 hours 1compartment NA NA Rat Human -DTXSID4023333 Css NA 2.066 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023333 Css NA 14.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023333 Css NA 1.213 mg/L PBTK NA 50% Rat Human -DTXSID4023333 Css NA 7.932 mg/L PBTK NA 95% Rat Human -DTXSID4023381 Clint NA 39.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023381 Fup NA 0.0866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023381 Vd NA 2.397 L/kg 1compartment NA NA Human Human -DTXSID4023381 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023381 TK.Half.Life NA 6.856 hours 1compartment NA NA Human Human -DTXSID4023381 Css NA 0.2946 mg/L 3compartmentss NA 50% Human Human -DTXSID4023381 Css NA 2.078 mg/L 3compartmentss NA 95% Human Human -DTXSID4023381 Css NA 0.2007 mg/L PBTK NA 50% Human Human -DTXSID4023381 Css NA 1.343 mg/L PBTK NA 95% Human Human -DTXSID4023381 Clint NA 39.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023381 Fup NA 0.0866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023381 Vd NA 1.805 L/kg 1compartment NA NA Rat Human +DTXSID4023333 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4023333 TK.Half.Life NA 9.147 hours 1compartment NA NA Rat Human +DTXSID4023333 Css NA 0.313 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023333 Css NA 2.375 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023333 Css NA 0.1905 mg/L PBTK NA 50% Rat Human +DTXSID4023333 Css NA 1.375 mg/L PBTK NA 95% Rat Human +DTXSID4023381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023381 Fup 0.0269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023381 Vd NA 2.037 L/kg 1compartment NA NA Human Human +DTXSID4023381 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4023381 TK.Half.Life NA 17.26 hours 1compartment NA NA Human Human +DTXSID4023381 Css NA 1.213 mg/L 3compartmentss NA 50% Human Human +DTXSID4023381 Css NA 10.61 mg/L 3compartmentss NA 95% Human Human +DTXSID4023381 Css NA 0.7808 mg/L PBTK NA 50% Human Human +DTXSID4023381 Css NA 6.397 mg/L PBTK NA 95% Human Human +DTXSID4023381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023381 Fup 0.0269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023381 Vd NA 1.518 L/kg 1compartment NA NA Rat Human DTXSID4023381 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023381 TK.Half.Life NA 1.951 hours 1compartment NA NA Rat Human -DTXSID4023381 Css NA 0.1655 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023381 Css NA 0.9255 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023381 Css NA 0.1073 mg/L PBTK NA 50% Rat Human -DTXSID4023381 Css NA 0.58 mg/L PBTK NA 95% Rat Human -DTXSID4023385 Clint NA 16.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023385 Fup NA 0.066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023385 Vd NA 1.141 L/kg 1compartment NA NA Human Human +DTXSID4023381 TK.Half.Life NA 5.484 hours 1compartment NA NA Rat Human +DTXSID4023381 Css NA 0.1571 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023381 Css NA 1.027 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023381 Css NA 0.09902 mg/L PBTK NA 50% Rat Human +DTXSID4023381 Css NA 0.6154 mg/L PBTK NA 95% Rat Human +DTXSID4023385 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023385 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023385 Vd NA 1.911 L/kg 1compartment NA NA Human Human DTXSID4023385 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023385 TK.Half.Life NA 5.045 hours 1compartment NA NA Human Human -DTXSID4023385 Css NA 0.6166 mg/L 3compartmentss NA 50% Human Human -DTXSID4023385 Css NA 4.633 mg/L 3compartmentss NA 95% Human Human -DTXSID4023385 Css NA 0.3955 mg/L PBTK NA 50% Human Human -DTXSID4023385 Css NA 2.812 mg/L PBTK NA 95% Human Human -DTXSID4023385 Clint NA 16.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023385 Fup NA 0.066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023385 Vd NA 0.915 L/kg 1compartment NA NA Rat Human +DTXSID4023385 TK.Half.Life NA 8.535 hours 1compartment NA NA Human Human +DTXSID4023385 Css NA 0.4314 mg/L 3compartmentss NA 50% Human Human +DTXSID4023385 Css NA 2.485 mg/L 3compartmentss NA 95% Human Human +DTXSID4023385 Css NA 0.3206 mg/L PBTK NA 50% Human Human +DTXSID4023385 Css NA 1.748 mg/L PBTK NA 95% Human Human +DTXSID4023385 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023385 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023385 Vd NA 1.556 L/kg 1compartment NA NA Rat Human DTXSID4023385 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023385 TK.Half.Life NA 2.309 hours 1compartment NA NA Rat Human -DTXSID4023385 Css NA 0.343 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023385 Css NA 1.963 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023385 Css NA 0.2078 mg/L PBTK NA 50% Rat Human -DTXSID4023385 Css NA 1.111 mg/L PBTK NA 95% Rat Human -DTXSID4023387 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023387 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023387 Vd NA 2.892 L/kg 1compartment NA NA Human Human -DTXSID4023387 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023387 TK.Half.Life NA 5.497 hours 1compartment NA NA Human Human -DTXSID4023387 Css NA 0.1314 mg/L 3compartmentss NA 50% Human Human -DTXSID4023387 Css NA 1.053 mg/L 3compartmentss NA 95% Human Human -DTXSID4023387 Css NA 0.1297 mg/L PBTK NA 50% Human Human -DTXSID4023387 Css NA 0.862 mg/L PBTK NA 95% Human Human -DTXSID4023387 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023387 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023387 Vd NA 2.883 L/kg 1compartment NA NA Rat Human +DTXSID4023385 TK.Half.Life NA 3.304 hours 1compartment NA NA Rat Human +DTXSID4023385 Css NA 0.05221 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023385 Css NA 0.2089 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023385 Css NA 0.03883 mg/L PBTK NA 50% Rat Human +DTXSID4023385 Css NA 0.142 mg/L PBTK NA 95% Rat Human +DTXSID4023387 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023387 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023387 Vd NA 2.903 L/kg 1compartment NA NA Human Human +DTXSID4023387 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4023387 TK.Half.Life NA 18.83 hours 1compartment NA NA Human Human +DTXSID4023387 Css NA 0.7144 mg/L 3compartmentss NA 50% Human Human +DTXSID4023387 Css NA 4.503 mg/L 3compartmentss NA 95% Human Human +DTXSID4023387 Css NA 0.4996 mg/L PBTK NA 50% Human Human +DTXSID4023387 Css NA 3.034 mg/L PBTK NA 95% Human Human +DTXSID4023387 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023387 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023387 Vd NA 2.185 L/kg 1compartment NA NA Rat Human DTXSID4023387 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023387 TK.Half.Life NA 3.193 hours 1compartment NA NA Rat Human -DTXSID4023387 Css NA 0.06933 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023387 Css NA 0.4245 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023387 Css NA 0.06718 mg/L PBTK NA 50% Rat Human -DTXSID4023387 Css NA 0.3239 mg/L PBTK NA 95% Rat Human +DTXSID4023387 TK.Half.Life NA 3.633 hours 1compartment NA NA Rat Human +DTXSID4023387 Css NA 0.0925 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023387 Css NA 0.4732 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023387 Css NA 0.06398 mg/L PBTK NA 50% Rat Human +DTXSID4023387 Css NA 0.3224 mg/L PBTK NA 95% Rat Human +DTXSID4023389 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023389 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4023389 Vd NA 1.261 L/kg 1compartment NA NA Human Human +DTXSID4023389 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4023389 TK.Half.Life NA 23.3 hours 1compartment NA NA Human Human +DTXSID4023389 Css NA 1.645 mg/L 3compartmentss NA 50% Human Human +DTXSID4023389 Css NA 7.209 mg/L 3compartmentss NA 95% Human Human +DTXSID4023389 Css NA 1.311 mg/L PBTK NA 50% Human Human +DTXSID4023389 Css NA 4.862 mg/L PBTK NA 95% Human Human +DTXSID4023389 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023389 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4023389 Vd NA 1.077 L/kg 1compartment NA NA Rat Human +DTXSID4023389 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023389 TK.Half.Life NA 6.139 hours 1compartment NA NA Rat Human +DTXSID4023389 Css NA 0.03868 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023389 Css NA 0.2351 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023389 Css NA 0.03138 mg/L PBTK NA 50% Rat Human +DTXSID4023389 Css NA 0.1559 mg/L PBTK NA 95% Rat Human DTXSID4023412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4023412 Fup 0.3982 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID4023412 Vd NA 0.354 L/kg 1compartment NA NA Human Human -DTXSID4023412 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023412 TK.Half.Life NA 5.752 hours 1compartment NA NA Human Human -DTXSID4023412 Css NA 1.982 mg/L 3compartmentss NA 50% Human Human -DTXSID4023412 Css NA 8.253 mg/L 3compartmentss NA 95% Human Human -DTXSID4023412 Css NA 1.343 mg/L PBTK NA 50% Human Human -DTXSID4023412 Css NA 5.086 mg/L PBTK NA 95% Human Human +DTXSID4023412 Vd NA 0.7627 L/kg 1compartment NA NA Human Human +DTXSID4023412 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4023412 TK.Half.Life NA 12.4 hours 1compartment NA NA Human Human +DTXSID4023412 Css NA 1.515 mg/L 3compartmentss NA 50% Human Human +DTXSID4023412 Css NA 6.637 mg/L 3compartmentss NA 95% Human Human +DTXSID4023412 Css NA 1.148 mg/L PBTK NA 50% Human Human +DTXSID4023412 Css NA 4.288 mg/L PBTK NA 95% Human Human DTXSID4023412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4023412 Fup 0.3982 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID4023412 Vd NA 0.3673 L/kg 1compartment NA NA Rat Human +DTXSID4023412 Vd NA 0.776 L/kg 1compartment NA NA Rat Human DTXSID4023412 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023412 TK.Half.Life NA 2.033 hours 1compartment NA NA Rat Human -DTXSID4023412 Css NA 0.5493 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023412 Css NA 1.911 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023412 Css NA 0.3512 mg/L PBTK NA 50% Rat Human -DTXSID4023412 Css NA 1.093 mg/L PBTK NA 95% Rat Human +DTXSID4023412 TK.Half.Life NA 4.297 hours 1compartment NA NA Rat Human +DTXSID4023412 Css NA 0.02736 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023412 Css NA 0.1777 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023412 Css NA 0.02007 mg/L PBTK NA 50% Rat Human +DTXSID4023412 Css NA 0.1162 mg/L PBTK NA 95% Rat Human DTXSID4023414 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4023414 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4023414 Vd NA 0.6138 L/kg 1compartment NA NA Human Human +DTXSID4023414 Vd NA 0.5349 L/kg 1compartment NA NA Human Human DTXSID4023414 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023414 TK.Half.Life NA 5.672 hours 1compartment NA NA Human Human -DTXSID4023414 Css NA 1.12 mg/L 3compartmentss NA 50% Human Human -DTXSID4023414 Css NA 7.128 mg/L 3compartmentss NA 95% Human Human -DTXSID4023414 Css NA 0.8836 mg/L PBTK NA 50% Human Human -DTXSID4023414 Css NA 4.453 mg/L PBTK NA 95% Human Human +DTXSID4023414 TK.Half.Life NA 4.944 hours 1compartment NA NA Human Human +DTXSID4023414 Css NA 0.9704 mg/L 3compartmentss NA 50% Human Human +DTXSID4023414 Css NA 6.368 mg/L 3compartmentss NA 95% Human Human +DTXSID4023414 Css NA 0.7498 mg/L PBTK NA 50% Human Human +DTXSID4023414 Css NA 3.966 mg/L PBTK NA 95% Human Human DTXSID4023414 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4023414 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4023414 Vd NA 0.6458 L/kg 1compartment NA NA Rat Human +DTXSID4023414 Vd NA 0.5815 L/kg 1compartment NA NA Rat Human DTXSID4023414 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023414 TK.Half.Life NA 2.034 hours 1compartment NA NA Rat Human -DTXSID4023414 Css NA 0.2913 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023414 Css NA 1.839 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023414 Css NA 0.2212 mg/L PBTK NA 50% Rat Human -DTXSID4023414 Css NA 1.076 mg/L PBTK NA 95% Rat Human -DTXSID4023416 Clint NA 41.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4023414 TK.Half.Life NA 1.831 hours 1compartment NA NA Rat Human +DTXSID4023414 Css NA 0.01853 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023414 Css NA 0.1495 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023414 Css NA 0.01372 mg/L PBTK NA 50% Rat Human +DTXSID4023414 Css NA 0.09257 mg/L PBTK NA 95% Rat Human +DTXSID4023416 Clint 8 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID4023416 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4023416 Vd NA 0.2571 L/kg 1compartment NA NA Human Human +DTXSID4023416 Vd NA 0.2629 L/kg 1compartment NA NA Human Human DTXSID4023416 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023416 TK.Half.Life NA 1.405 hours 1compartment NA NA Human Human -DTXSID4023416 Css NA 0.8658 mg/L 3compartmentss NA 50% Human Human -DTXSID4023416 Css NA 8.733 mg/L 3compartmentss NA 95% Human Human -DTXSID4023416 Css NA 0.5127 mg/L PBTK NA 50% Human Human -DTXSID4023416 Css NA 5.11 mg/L PBTK NA 95% Human Human -DTXSID4023416 Clint NA 41.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4023416 TK.Half.Life NA 6.012 hours 1compartment NA NA Human Human +DTXSID4023416 Css NA 4.094 mg/L 3compartmentss NA 50% Human Human +DTXSID4023416 Css NA 35.99 mg/L 3compartmentss NA 95% Human Human +DTXSID4023416 Css NA 2.419 mg/L PBTK NA 50% Human Human +DTXSID4023416 Css NA 21.07 mg/L PBTK NA 95% Human Human +DTXSID4023416 Clint 8 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID4023416 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4023416 Vd NA 0.2309 L/kg 1compartment NA NA Rat Human +DTXSID4023416 Vd NA 0.2347 L/kg 1compartment NA NA Rat Human DTXSID4023416 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023416 TK.Half.Life NA 0.8124 hours 1compartment NA NA Rat Human -DTXSID4023416 Css NA 0.5011 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023416 Css NA 4.096 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023416 Css NA 0.2755 mg/L PBTK NA 50% Rat Human -DTXSID4023416 Css NA 2.24 mg/L PBTK NA 95% Rat Human -DTXSID4023460 Clint NA 107.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023460 Fup NA 0.6541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023460 Vd NA 1.018 L/kg 1compartment NA NA Human Human +DTXSID4023416 TK.Half.Life NA 3.452 hours 1compartment NA NA Rat Human +DTXSID4023416 Css NA 0.5048 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023416 Css NA 3.556 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023416 Css NA 0.2876 mg/L PBTK NA 50% Rat Human +DTXSID4023416 Css NA 1.998 mg/L PBTK NA 95% Rat Human +DTXSID4023418 Clint 35 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID4023418 Fup 0.073 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4023418 Vd NA 1.612 L/kg 1compartment NA NA Human Human +DTXSID4023418 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023418 TK.Half.Life NA 4.173 hours 1compartment NA NA Human Human +DTXSID4023418 Css NA 0.2659 mg/L 3compartmentss NA 50% Human Human +DTXSID4023418 Css NA 2.133 mg/L 3compartmentss NA 95% Human Human +DTXSID4023418 Css NA 0.1746 mg/L PBTK NA 50% Human Human +DTXSID4023418 Css NA 1.309 mg/L PBTK NA 95% Human Human +DTXSID4023418 Clint 35 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID4023418 Fup 0.073 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4023418 Vd NA 1.229 L/kg 1compartment NA NA Rat Human +DTXSID4023418 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023418 TK.Half.Life NA 1.571 hours 1compartment NA NA Rat Human +DTXSID4023418 Css NA 0.03532 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023418 Css NA 0.2205 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023418 Css NA 0.02258 mg/L PBTK NA 50% Rat Human +DTXSID4023418 Css NA 0.135 mg/L PBTK NA 95% Rat Human +DTXSID4023460 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023460 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023460 Vd NA 0.8682 L/kg 1compartment NA NA Human Human DTXSID4023460 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023460 TK.Half.Life NA 0.6652 hours 1compartment NA NA Human Human -DTXSID4023460 Css NA 0.006607 mg/L 3compartmentss NA 50% Human Human -DTXSID4023460 Css NA 0.07687 mg/L 3compartmentss NA 95% Human Human -DTXSID4023460 Css NA 0.005567 mg/L PBTK NA 50% Human Human -DTXSID4023460 Css NA 0.05397 mg/L PBTK NA 95% Human Human -DTXSID4023460 Clint NA 107.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023460 Fup NA 0.6541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023460 Vd NA 0.9648 L/kg 1compartment NA NA Rat Human +DTXSID4023460 TK.Half.Life NA 0.7936 hours 1compartment NA NA Human Human +DTXSID4023460 Css NA 0.03377 mg/L 3compartmentss NA 50% Human Human +DTXSID4023460 Css NA 0.3776 mg/L 3compartmentss NA 95% Human Human +DTXSID4023460 Css NA 0.02742 mg/L PBTK NA 50% Human Human +DTXSID4023460 Css NA 0.2584 mg/L PBTK NA 95% Human Human +DTXSID4023460 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023460 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023460 Vd NA 0.8365 L/kg 1compartment NA NA Rat Human DTXSID4023460 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023460 TK.Half.Life NA 0.282 hours 1compartment NA NA Rat Human -DTXSID4023460 Css NA 0.003485 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023460 Css NA 0.0349 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023460 Css NA 0.002878 mg/L PBTK NA 50% Rat Human -DTXSID4023460 Css NA 0.02364 mg/L PBTK NA 95% Rat Human -DTXSID4023462 Clint NA 14.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023462 Fup NA 0.1199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023462 Vd NA 2.838 L/kg 1compartment NA NA Human Human +DTXSID4023460 TK.Half.Life NA 0.3804 hours 1compartment NA NA Rat Human +DTXSID4023460 Css NA 0.004133 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023460 Css NA 0.03985 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023460 Css NA 0.00336 mg/L PBTK NA 50% Rat Human +DTXSID4023460 Css NA 0.02641 mg/L PBTK NA 95% Rat Human +DTXSID4023462 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023462 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023462 Vd NA 4.872 L/kg 1compartment NA NA Human Human DTXSID4023462 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023462 TK.Half.Life NA 6.017 hours 1compartment NA NA Human Human -DTXSID4023462 Css NA 0.1816 mg/L 3compartmentss NA 50% Human Human -DTXSID4023462 Css NA 1.623 mg/L 3compartmentss NA 95% Human Human -DTXSID4023462 Css NA 0.1628 mg/L PBTK NA 50% Human Human -DTXSID4023462 Css NA 1.177 mg/L PBTK NA 95% Human Human -DTXSID4023462 Clint NA 14.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023462 Fup NA 0.1199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023462 Vd NA 2.768 L/kg 1compartment NA NA Rat Human +DTXSID4023462 TK.Half.Life NA 8.983 hours 1compartment NA NA Human Human +DTXSID4023462 Css NA 0.09436 mg/L 3compartmentss NA 50% Human Human +DTXSID4023462 Css NA 0.7566 mg/L 3compartmentss NA 95% Human Human +DTXSID4023462 Css NA 0.1296 mg/L PBTK NA 50% Human Human +DTXSID4023462 Css NA 0.7631 mg/L PBTK NA 95% Human Human +DTXSID4023462 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023462 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023462 Vd NA 4.877 L/kg 1compartment NA NA Rat Human DTXSID4023462 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023462 TK.Half.Life NA 3.344 hours 1compartment NA NA Rat Human -DTXSID4023462 Css NA 0.09762 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023462 Css NA 0.7057 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023462 Css NA 0.08626 mg/L PBTK NA 50% Rat Human -DTXSID4023462 Css NA 0.4954 mg/L PBTK NA 95% Rat Human +DTXSID4023462 TK.Half.Life NA 4.804 hours 1compartment NA NA Rat Human +DTXSID4023462 Css NA 0.01066 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023462 Css NA 0.06358 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023462 Css NA 0.01547 mg/L PBTK NA 50% Rat Human +DTXSID4023462 Css NA 0.06382 mg/L PBTK NA 95% Rat Human DTXSID4023541 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4023541 Fup NA 0.9477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023541 Vd NA 0.7958 L/kg 1compartment NA NA Human Human +DTXSID4023541 Fup 0.892 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023541 Vd NA 0.7538 L/kg 1compartment NA NA Human Human DTXSID4023541 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023541 TK.Half.Life NA 5.441 hours 1compartment NA NA Human Human -DTXSID4023541 Css NA 0.8504 mg/L 3compartmentss NA 50% Human Human -DTXSID4023541 Css NA 3.082 mg/L 3compartmentss NA 95% Human Human -DTXSID4023541 Css NA 0.716 mg/L PBTK NA 50% Human Human -DTXSID4023541 Css NA 2.16 mg/L PBTK NA 95% Human Human +DTXSID4023541 TK.Half.Life NA 5.475 hours 1compartment NA NA Human Human +DTXSID4023541 Css NA 0.797 mg/L 3compartmentss NA 50% Human Human +DTXSID4023541 Css NA 4.503 mg/L 3compartmentss NA 95% Human Human +DTXSID4023541 Css NA 0.6617 mg/L PBTK NA 50% Human Human +DTXSID4023541 Css NA 2.919 mg/L PBTK NA 95% Human Human DTXSID4023541 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4023541 Fup NA 0.9477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023541 Vd NA 0.827 L/kg 1compartment NA NA Rat Human +DTXSID4023541 Fup 0.892 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023541 Vd NA 0.7837 L/kg 1compartment NA NA Rat Human DTXSID4023541 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023541 TK.Half.Life NA 1.925 hours 1compartment NA NA Rat Human -DTXSID4023541 Css NA 0.219 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023541 Css NA 0.7058 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023541 Css NA 0.1802 mg/L PBTK NA 50% Rat Human -DTXSID4023541 Css NA 0.4594 mg/L PBTK NA 95% Rat Human +DTXSID4023541 TK.Half.Life NA 1.938 hours 1compartment NA NA Rat Human +DTXSID4023541 Css NA 0.02055 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023541 Css NA 0.138 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023541 Css NA 0.0165 mg/L PBTK NA 50% Rat Human +DTXSID4023541 Css NA 0.08951 mg/L PBTK NA 95% Rat Human DTXSID4023545 Clint NA 67.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4023545 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023545 Vd NA 0.2521 L/kg 1compartment NA NA Human Human -DTXSID4023545 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023545 TK.Half.Life NA 6.4 hours 1compartment NA NA Human Human -DTXSID4023545 Css NA 4.777 mg/L 3compartmentss NA 50% Human Human -DTXSID4023545 Css NA 40.86 mg/L 3compartmentss NA 95% Human Human -DTXSID4023545 Css NA 2.805 mg/L PBTK NA 50% Human Human -DTXSID4023545 Css NA 24.12 mg/L PBTK NA 95% Human Human +DTXSID4023545 Vd NA 2.817 L/kg 1compartment NA NA Human Human +DTXSID4023545 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4023545 TK.Half.Life NA 29.65 hours 1compartment NA NA Human Human +DTXSID4023545 Css NA 1.309 mg/L 3compartmentss NA 50% Human Human +DTXSID4023545 Css NA 8.75 mg/L 3compartmentss NA 95% Human Human +DTXSID4023545 Css NA 0.8778 mg/L PBTK NA 50% Human Human +DTXSID4023545 Css NA 5.729 mg/L PBTK NA 95% Human Human DTXSID4023545 Clint NA 67.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4023545 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023545 Vd NA 0.226 L/kg 1compartment NA NA Rat Human -DTXSID4023545 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023545 TK.Half.Life NA 3.927 hours 1compartment NA NA Rat Human -DTXSID4023545 Css NA 2.775 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023545 Css NA 17.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023545 Css NA 1.517 mg/L PBTK NA 50% Rat Human -DTXSID4023545 Css NA 9.779 mg/L PBTK NA 95% Rat Human +DTXSID4023545 Vd NA 2.102 L/kg 1compartment NA NA Rat Human +DTXSID4023545 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4023545 TK.Half.Life NA 5.835 hours 1compartment NA NA Rat Human +DTXSID4023545 Css NA 0.1733 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023545 Css NA 0.9229 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023545 Css NA 0.1146 mg/L PBTK NA 50% Rat Human +DTXSID4023545 Css NA 0.6041 mg/L PBTK NA 95% Rat Human DTXSID4023549 Clint 6.62 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4023549 Fup 0.13 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID4023549 Vd NA 2.793 L/kg 1compartment NA NA Human Human DTXSID4023549 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4023549 TK.Half.Life NA 12.12 hours 1compartment NA NA Human Human -DTXSID4023549 Css NA 0.4583 mg/L 3compartmentss NA 50% Human Human -DTXSID4023549 Css NA 3.436 mg/L 3compartmentss NA 95% Human Human -DTXSID4023549 Css NA 0.3638 mg/L PBTK NA 50% Human Human -DTXSID4023549 Css NA 2.386 mg/L PBTK NA 95% Human Human +DTXSID4023549 Css NA 0.4091 mg/L 3compartmentss NA 50% Human Human +DTXSID4023549 Css NA 2.603 mg/L 3compartmentss NA 95% Human Human +DTXSID4023549 Css NA 0.3678 mg/L PBTK NA 50% Human Human +DTXSID4023549 Css NA 2.34 mg/L PBTK NA 95% Human Human DTXSID4023549 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4023549 Fup 0.33 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID4023549 Vd NA 4.018 L/kg 1compartment NA NA Rat Rat DTXSID4023549 Days.Css NA 9 Days PBTK NA NA Rat Rat DTXSID4023549 TK.Half.Life NA 32.15 hours 1compartment NA NA Rat Rat -DTXSID4023549 Css NA 1.065 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4023549 Css NA 2.982 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4023549 Css NA 0.7719 mg/L PBTK NA 50% Rat Rat -DTXSID4023549 Css NA 1.841 mg/L PBTK NA 95% Rat Rat -DTXSID4023591 Clint NA 3.989 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023591 Fup NA 0.3395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023591 Vd NA 1.663 L/kg 1compartment NA NA Human Human -DTXSID4023591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023591 TK.Half.Life NA 4.636 hours 1compartment NA NA Human Human -DTXSID4023591 Css NA 0.2193 mg/L 3compartmentss NA 50% Human Human -DTXSID4023591 Css NA 1.438 mg/L 3compartmentss NA 95% Human Human -DTXSID4023591 Css NA 0.2044 mg/L PBTK NA 50% Human Human -DTXSID4023591 Css NA 1.1 mg/L PBTK NA 95% Human Human -DTXSID4023591 Clint NA 3.989 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023591 Fup NA 0.3395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023591 Vd NA 1.63 L/kg 1compartment NA NA Rat Human -DTXSID4023591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023591 TK.Half.Life NA 2.62 hours 1compartment NA NA Rat Human -DTXSID4023591 Css NA 0.1046 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023591 Css NA 0.5455 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023591 Css NA 0.0959 mg/L PBTK NA 50% Rat Human -DTXSID4023591 Css NA 0.381 mg/L PBTK NA 95% Rat Human -DTXSID4023593 Clint NA 36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023593 Fup NA 0.0291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023593 Vd NA 2.657 L/kg 1compartment NA NA Human Human -DTXSID4023593 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4023593 TK.Half.Life NA 18.87 hours 1compartment NA NA Human Human -DTXSID4023593 Css NA 0.922 mg/L 3compartmentss NA 50% Human Human -DTXSID4023593 Css NA 6.331 mg/L 3compartmentss NA 95% Human Human -DTXSID4023593 Css NA 0.6182 mg/L PBTK NA 50% Human Human -DTXSID4023593 Css NA 4.074 mg/L PBTK NA 95% Human Human -DTXSID4023593 Clint NA 36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023593 Fup NA 0.0291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023593 Vd NA 1.988 L/kg 1compartment NA NA Rat Human -DTXSID4023593 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023593 TK.Half.Life NA 4.34 hours 1compartment NA NA Rat Human -DTXSID4023593 Css NA 0.5188 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023593 Css NA 2.989 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023593 Css NA 0.33 mg/L PBTK NA 50% Rat Human -DTXSID4023593 Css NA 1.853 mg/L PBTK NA 95% Rat Human -DTXSID4023595 Clint NA 517.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023595 Fup NA 0.3493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023595 Vd NA 3.254 L/kg 1compartment NA NA Human Human -DTXSID4023595 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023595 TK.Half.Life NA 2.389 hours 1compartment NA NA Human Human -DTXSID4023595 Css NA 0.00715 mg/L 3compartmentss NA 50% Human Human -DTXSID4023595 Css NA 0.04885 mg/L 3compartmentss NA 95% Human Human -DTXSID4023595 Css NA 0.0059 mg/L PBTK NA 50% Human Human -DTXSID4023595 Css NA 0.03784 mg/L PBTK NA 95% Human Human -DTXSID4023595 Clint NA 517.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023595 Fup NA 0.3493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023595 Vd NA 2.661 L/kg 1compartment NA NA Rat Human -DTXSID4023595 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023595 TK.Half.Life NA 0.8176 hours 1compartment NA NA Rat Human -DTXSID4023595 Css NA 0.003947 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023595 Css NA 0.02259 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023595 Css NA 0.00317 mg/L PBTK NA 50% Rat Human -DTXSID4023595 Css NA 0.01692 mg/L PBTK NA 95% Rat Human -DTXSID4023620 Clint NA 45.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023620 Fup NA 0.189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023620 Vd NA 0.464 L/kg 1compartment NA NA Human Human +DTXSID4023549 Css NA 0.1941 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4023549 Css NA 0.4669 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4023549 Css NA 0.181 mg/L PBTK NA 50% Rat Rat +DTXSID4023549 Css NA 0.4353 mg/L PBTK NA 95% Rat Rat +DTXSID4023591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023591 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023591 Vd NA 2.202 L/kg 1compartment NA NA Human Human +DTXSID4023591 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4023591 TK.Half.Life NA 41.11 hours 1compartment NA NA Human Human +DTXSID4023591 Css NA 1.4 mg/L 3compartmentss NA 50% Human Human +DTXSID4023591 Css NA 7.034 mg/L 3compartmentss NA 95% Human Human +DTXSID4023591 Css NA 1.494 mg/L PBTK NA 50% Human Human +DTXSID4023591 Css NA 5.368 mg/L PBTK NA 95% Human Human +DTXSID4023591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023591 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023591 Vd NA 2.166 L/kg 1compartment NA NA Rat Human +DTXSID4023591 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4023591 TK.Half.Life NA 13.76 hours 1compartment NA NA Rat Human +DTXSID4023591 Css NA 0.0862 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023591 Css NA 0.3873 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023591 Css NA 0.0941 mg/L PBTK NA 50% Rat Human +DTXSID4023591 Css NA 0.2848 mg/L PBTK NA 95% Rat Human +DTXSID4023593 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023593 Fup 0.0723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023593 Vd NA 2.826 L/kg 1compartment NA NA Human Human +DTXSID4023593 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4023593 TK.Half.Life NA 22.7 hours 1compartment NA NA Human Human +DTXSID4023593 Css NA 0.928 mg/L 3compartmentss NA 50% Human Human +DTXSID4023593 Css NA 6.026 mg/L 3compartmentss NA 95% Human Human +DTXSID4023593 Css NA 0.6387 mg/L PBTK NA 50% Human Human +DTXSID4023593 Css NA 4.026 mg/L PBTK NA 95% Human Human +DTXSID4023593 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023593 Fup 0.0723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023593 Vd NA 2.12 L/kg 1compartment NA NA Rat Human +DTXSID4023593 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4023593 TK.Half.Life NA 4.542 hours 1compartment NA NA Rat Human +DTXSID4023593 Css NA 0.1214 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023593 Css NA 0.6483 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023593 Css NA 0.08256 mg/L PBTK NA 50% Rat Human +DTXSID4023593 Css NA 0.4312 mg/L PBTK NA 95% Rat Human +DTXSID4023595 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023595 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023595 Vd NA 3.277 L/kg 1compartment NA NA Human Human +DTXSID4023595 Days.Css NA 49 Days PBTK NA NA Human Human +DTXSID4023595 TK.Half.Life NA 235.8 hours 1compartment NA NA Human Human +DTXSID4023595 Css NA 6.018 mg/L 3compartmentss NA 50% Human Human +DTXSID4023595 Css NA 18.57 mg/L 3compartmentss NA 95% Human Human +DTXSID4023595 Css NA 5.054 mg/L PBTK NA 50% Human Human +DTXSID4023595 Css NA 13.62 mg/L PBTK NA 95% Human Human +DTXSID4023595 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023595 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023595 Vd NA 2.682 L/kg 1compartment NA NA Rat Human +DTXSID4023595 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID4023595 TK.Half.Life NA 28.01 hours 1compartment NA NA Rat Human +DTXSID4023595 Css NA 0.1412 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023595 Css NA 0.6571 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023595 Css NA 0.1167 mg/L PBTK NA 50% Rat Human +DTXSID4023595 Css NA 0.4795 mg/L PBTK NA 95% Rat Human +DTXSID4023620 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023620 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023620 Vd NA 0.4353 L/kg 1compartment NA NA Human Human DTXSID4023620 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023620 TK.Half.Life NA 0.5869 hours 1compartment NA NA Human Human -DTXSID4023620 Css NA 0.05906 mg/L 3compartmentss NA 50% Human Human -DTXSID4023620 Css NA 0.4397 mg/L 3compartmentss NA 95% Human Human -DTXSID4023620 Css NA 0.03904 mg/L PBTK NA 50% Human Human -DTXSID4023620 Css NA 0.2752 mg/L PBTK NA 95% Human Human -DTXSID4023620 Clint NA 45.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023620 Fup NA 0.189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023620 Vd NA 0.4425 L/kg 1compartment NA NA Rat Human +DTXSID4023620 TK.Half.Life NA 1.81 hours 1compartment NA NA Human Human +DTXSID4023620 Css NA 0.4672 mg/L 3compartmentss NA 50% Human Human +DTXSID4023620 Css NA 2.791 mg/L 3compartmentss NA 95% Human Human +DTXSID4023620 Css NA 0.3048 mg/L PBTK NA 50% Human Human +DTXSID4023620 Css NA 1.739 mg/L PBTK NA 95% Human Human +DTXSID4023620 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023620 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023620 Vd NA 0.4145 L/kg 1compartment NA NA Rat Human DTXSID4023620 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023620 TK.Half.Life NA 0.2897 hours 1compartment NA NA Rat Human -DTXSID4023620 Css NA 0.03248 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023620 Css NA 0.1899 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023620 Css NA 0.02041 mg/L PBTK NA 50% Rat Human -DTXSID4023620 Css NA 0.1145 mg/L PBTK NA 95% Rat Human -DTXSID4023622 Clint NA 0.3265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023622 Fup NA 0.947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023622 Vd NA 0.8066 L/kg 1compartment NA NA Human Human +DTXSID4023620 TK.Half.Life NA 1.021 hours 1compartment NA NA Rat Human +DTXSID4023620 Css NA 0.05612 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023620 Css NA 0.252 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023620 Css NA 0.03597 mg/L PBTK NA 50% Rat Human +DTXSID4023620 Css NA 0.1518 mg/L PBTK NA 95% Rat Human +DTXSID4023622 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023622 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023622 Vd NA 0.5846 L/kg 1compartment NA NA Human Human DTXSID4023622 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023622 TK.Half.Life NA 3.642 hours 1compartment NA NA Human Human -DTXSID4023622 Css NA 0.539 mg/L 3compartmentss NA 50% Human Human -DTXSID4023622 Css NA 2.013 mg/L 3compartmentss NA 95% Human Human -DTXSID4023622 Css NA 0.4549 mg/L PBTK NA 50% Human Human -DTXSID4023622 Css NA 1.412 mg/L PBTK NA 95% Human Human -DTXSID4023622 Clint NA 0.3265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023622 Fup NA 0.947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023622 Vd NA 0.8355 L/kg 1compartment NA NA Rat Human +DTXSID4023622 TK.Half.Life NA 6.897 hours 1compartment NA NA Human Human +DTXSID4023622 Css NA 1.31 mg/L 3compartmentss NA 50% Human Human +DTXSID4023622 Css NA 8.474 mg/L 3compartmentss NA 95% Human Human +DTXSID4023622 Css NA 1.008 mg/L PBTK NA 50% Human Human +DTXSID4023622 Css NA 5.273 mg/L PBTK NA 95% Human Human +DTXSID4023622 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023622 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023622 Vd NA 0.6036 L/kg 1compartment NA NA Rat Human DTXSID4023622 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023622 TK.Half.Life NA 1.551 hours 1compartment NA NA Rat Human -DTXSID4023622 Css NA 0.1699 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023622 Css NA 0.5591 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023622 Css NA 0.1416 mg/L PBTK NA 50% Rat Human -DTXSID4023622 Css NA 0.3653 mg/L PBTK NA 95% Rat Human -DTXSID4023624 Clint NA 0.0779 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023624 Fup NA 0.0114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023624 Vd NA 0.3807 L/kg 1compartment NA NA Human Human -DTXSID4023624 Days.Css NA 45 Days PBTK NA NA Human Human -DTXSID4023624 TK.Half.Life NA 192.8 hours 1compartment NA NA Human Human -DTXSID4023624 Css NA 85.84 mg/L 3compartmentss NA 50% Human Human -DTXSID4023624 Css NA 536.5 mg/L 3compartmentss NA 95% Human Human -DTXSID4023624 Css NA 50.28 mg/L PBTK NA 50% Human Human -DTXSID4023624 Css NA 307.6 mg/L PBTK NA 95% Human Human -DTXSID4023624 Clint NA 0.0779 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023624 Fup NA 0.0114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023624 Vd NA 0.302 L/kg 1compartment NA NA Rat Human -DTXSID4023624 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID4023624 TK.Half.Life NA 54.84 hours 1compartment NA NA Rat Human -DTXSID4023624 Css NA 26.43 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023624 Css NA 147.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023624 Css NA 14.52 mg/L PBTK NA 50% Rat Human -DTXSID4023624 Css NA 80.09 mg/L PBTK NA 95% Rat Human -DTXSID4023626 Clint NA 3.837 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023626 Fup NA 0.3452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023626 Vd NA 0.3894 L/kg 1compartment NA NA Human Human +DTXSID4023622 TK.Half.Life NA 2.424 hours 1compartment NA NA Rat Human +DTXSID4023622 Css NA 0.0786 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023622 Css NA 0.4609 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023622 Css NA 0.06004 mg/L PBTK NA 50% Rat Human +DTXSID4023622 Css NA 0.2783 mg/L PBTK NA 95% Rat Human +DTXSID4023624 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023624 Fup 0.0445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023624 Vd NA 0.7211 L/kg 1compartment NA NA Human Human +DTXSID4023624 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023624 TK.Half.Life NA 9.538 hours 1compartment NA NA Human Human +DTXSID4023624 Css NA 2.124 mg/L 3compartmentss NA 50% Human Human +DTXSID4023624 Css NA 15.89 mg/L 3compartmentss NA 95% Human Human +DTXSID4023624 Css NA 1.305 mg/L PBTK NA 50% Human Human +DTXSID4023624 Css NA 9.416 mg/L PBTK NA 95% Human Human +DTXSID4023624 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023624 Fup 0.0445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023624 Vd NA 0.5569 L/kg 1compartment NA NA Rat Human +DTXSID4023624 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023624 TK.Half.Life NA 4.39 hours 1compartment NA NA Rat Human +DTXSID4023624 Css NA 0.2583 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023624 Css NA 1.45 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023624 Css NA 0.1532 mg/L PBTK NA 50% Rat Human +DTXSID4023624 Css NA 0.829 mg/L PBTK NA 95% Rat Human +DTXSID4023626 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023626 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023626 Vd NA 0.3989 L/kg 1compartment NA NA Human Human DTXSID4023626 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023626 TK.Half.Life NA 1.227 hours 1compartment NA NA Human Human -DTXSID4023626 Css NA 0.3249 mg/L 3compartmentss NA 50% Human Human -DTXSID4023626 Css NA 1.807 mg/L 3compartmentss NA 95% Human Human -DTXSID4023626 Css NA 0.2234 mg/L PBTK NA 50% Human Human -DTXSID4023626 Css NA 1.156 mg/L PBTK NA 95% Human Human -DTXSID4023626 Clint NA 3.837 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023626 Fup NA 0.3452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023626 Vd NA 0.3897 L/kg 1compartment NA NA Rat Human +DTXSID4023626 TK.Half.Life NA 0.8899 hours 1compartment NA NA Human Human +DTXSID4023626 Css NA 0.1936 mg/L 3compartmentss NA 50% Human Human +DTXSID4023626 Css NA 1.206 mg/L 3compartmentss NA 95% Human Human +DTXSID4023626 Css NA 0.1322 mg/L PBTK NA 50% Human Human +DTXSID4023626 Css NA 0.7641 mg/L PBTK NA 95% Human Human +DTXSID4023626 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023626 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023626 Vd NA 0.3992 L/kg 1compartment NA NA Rat Human DTXSID4023626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023626 TK.Half.Life NA 0.6876 hours 1compartment NA NA Rat Human -DTXSID4023626 Css NA 0.1569 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023626 Css NA 0.6576 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023626 Css NA 0.1024 mg/L PBTK NA 50% Rat Human -DTXSID4023626 Css NA 0.3879 mg/L PBTK NA 95% Rat Human +DTXSID4023626 TK.Half.Life NA 0.4987 hours 1compartment NA NA Rat Human +DTXSID4023626 Css NA 0.0225 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023626 Css NA 0.1075 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023626 Css NA 0.01528 mg/L PBTK NA 50% Rat Human +DTXSID4023626 Css NA 0.06593 mg/L PBTK NA 95% Rat Human DTXSID4023628 Clint 2.414 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4023628 Fup 0.83 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4023628 Vd NA 3.048 L/kg 1compartment NA NA Human Human DTXSID4023628 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4023628 TK.Half.Life NA 5.705 hours 1compartment NA NA Human Human -DTXSID4023628 Css NA 0.1481 mg/L 3compartmentss NA 50% Human Human -DTXSID4023628 Css NA 1.08 mg/L 3compartmentss NA 95% Human Human -DTXSID4023628 Css NA 0.1391 mg/L PBTK NA 50% Human Human -DTXSID4023628 Css NA 0.7658 mg/L PBTK NA 95% Human Human +DTXSID4023628 Css NA 0.1449 mg/L 3compartmentss NA 50% Human Human +DTXSID4023628 Css NA 0.8439 mg/L 3compartmentss NA 95% Human Human +DTXSID4023628 Css NA 0.1482 mg/L PBTK NA 50% Human Human +DTXSID4023628 Css NA 0.8671 mg/L PBTK NA 95% Human Human DTXSID4023628 Clint 2.414 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID4023628 Fup 0.83 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4023628 Vd NA 3.081 L/kg 1compartment NA NA Rat Human DTXSID4023628 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4023628 TK.Half.Life NA 3.06 hours 1compartment NA NA Rat Human -DTXSID4023628 Css NA 0.07424 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023628 Css NA 0.5465 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023628 Css NA 0.06987 mg/L PBTK NA 50% Rat Human -DTXSID4023628 Css NA 0.3495 mg/L PBTK NA 95% Rat Human -DTXSID4023670 Clint NA 0.459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023670 Fup NA 0.0106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023670 Vd NA 0.2452 L/kg 1compartment NA NA Human Human -DTXSID4023670 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID4023670 TK.Half.Life NA 84.43 hours 1compartment NA NA Human Human -DTXSID4023670 Css NA 58.53 mg/L 3compartmentss NA 50% Human Human -DTXSID4023670 Css NA 377.7 mg/L 3compartmentss NA 95% Human Human -DTXSID4023670 Css NA 34.64 mg/L PBTK NA 50% Human Human -DTXSID4023670 Css NA 221.3 mg/L PBTK NA 95% Human Human -DTXSID4023670 Clint NA 0.459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023670 Fup NA 0.0106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023670 Vd NA 0.2342 L/kg 1compartment NA NA Rat Human -DTXSID4023670 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID4023670 TK.Half.Life NA 35.4 hours 1compartment NA NA Rat Human -DTXSID4023670 Css NA 21.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023670 Css NA 128.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023670 Css NA 12.08 mg/L PBTK NA 50% Rat Human -DTXSID4023670 Css NA 69.45 mg/L PBTK NA 95% Rat Human -DTXSID4023672 Clint NA 6.216 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023672 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023672 Vd NA 3.133 L/kg 1compartment NA NA Human Human -DTXSID4023672 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4023672 TK.Half.Life NA 28.58 hours 1compartment NA NA Human Human -DTXSID4023672 Css NA 1.013 mg/L 3compartmentss NA 50% Human Human -DTXSID4023672 Css NA 6.368 mg/L 3compartmentss NA 95% Human Human -DTXSID4023672 Css NA 0.751 mg/L PBTK NA 50% Human Human -DTXSID4023672 Css NA 4.562 mg/L PBTK NA 95% Human Human -DTXSID4023672 Clint NA 6.216 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023672 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023672 Vd NA 2.382 L/kg 1compartment NA NA Rat Human -DTXSID4023672 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4023672 TK.Half.Life NA 4.242 hours 1compartment NA NA Rat Human -DTXSID4023672 Css NA 0.514 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023672 Css NA 2.394 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023672 Css NA 0.3696 mg/L PBTK NA 50% Rat Human -DTXSID4023672 Css NA 1.615 mg/L PBTK NA 95% Rat Human +DTXSID4023628 Css NA 0.008663 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023628 Css NA 0.04594 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023628 Css NA 0.009164 mg/L PBTK NA 50% Rat Human +DTXSID4023628 Css NA 0.0489 mg/L PBTK NA 95% Rat Human +DTXSID40236689 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40236689 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40236689 Vd NA 0.314 L/kg 1compartment NA NA Human Human +DTXSID40236689 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID40236689 TK.Half.Life NA 16.86 hours 1compartment NA NA Human Human +DTXSID40236689 Css NA 9.779 mg/L 3compartmentss NA 50% Human Human +DTXSID40236689 Css NA 85.83 mg/L 3compartmentss NA 95% Human Human +DTXSID40236689 Css NA 5.76 mg/L PBTK NA 50% Human Human +DTXSID40236689 Css NA 49.7 mg/L PBTK NA 95% Human Human +DTXSID40236689 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40236689 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40236689 Vd NA 0.2568 L/kg 1compartment NA NA Rat Human +DTXSID40236689 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40236689 TK.Half.Life NA 8.782 hours 1compartment NA NA Rat Human +DTXSID40236689 Css NA 1.217 mg/L 3compartmentss NA 50% Rat Human +DTXSID40236689 Css NA 8.493 mg/L 3compartmentss NA 95% Rat Human +DTXSID40236689 Css NA 0.6893 mg/L PBTK NA 50% Rat Human +DTXSID40236689 Css NA 4.762 mg/L PBTK NA 95% Rat Human +DTXSID4023670 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023670 Fup 0.0501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023670 Vd NA 0.6648 L/kg 1compartment NA NA Human Human +DTXSID4023670 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023670 TK.Half.Life NA 7.81 hours 1compartment NA NA Human Human +DTXSID4023670 Css NA 1.757 mg/L 3compartmentss NA 50% Human Human +DTXSID4023670 Css NA 13.45 mg/L 3compartmentss NA 95% Human Human +DTXSID4023670 Css NA 1.187 mg/L PBTK NA 50% Human Human +DTXSID4023670 Css NA 8.271 mg/L PBTK NA 95% Human Human +DTXSID4023670 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023670 Fup 0.0501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023670 Vd NA 0.6125 L/kg 1compartment NA NA Rat Human +DTXSID4023670 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023670 TK.Half.Life NA 4.458 hours 1compartment NA NA Rat Human +DTXSID4023670 Css NA 0.2138 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023670 Css NA 1.288 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023670 Css NA 0.142 mg/L PBTK NA 50% Rat Human +DTXSID4023670 Css NA 0.7654 mg/L PBTK NA 95% Rat Human DTXSID4023674 Clint 3.816 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4023674 Fup 0.4 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Human Human DTXSID4023674 Vd NA 1.64 L/kg 1compartment NA NA Human Human DTXSID4023674 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4023674 TK.Half.Life NA 4.247 hours 1compartment NA NA Human Human -DTXSID4023674 Css NA 0.2162 mg/L 3compartmentss NA 50% Human Human -DTXSID4023674 Css NA 1.412 mg/L 3compartmentss NA 95% Human Human -DTXSID4023674 Css NA 0.1826 mg/L PBTK NA 50% Human Human -DTXSID4023674 Css NA 0.9834 mg/L PBTK NA 95% Human Human +DTXSID4023674 Css NA 0.2041 mg/L 3compartmentss NA 50% Human Human +DTXSID4023674 Css NA 1.113 mg/L 3compartmentss NA 95% Human Human +DTXSID4023674 Css NA 0.1706 mg/L PBTK NA 50% Human Human +DTXSID4023674 Css NA 0.9326 mg/L PBTK NA 95% Human Human DTXSID4023674 Clint 3.816 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID4023674 Fup 0.4 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Rat Human DTXSID4023674 Vd NA 2.253 L/kg 1compartment NA NA Rat Human DTXSID4023674 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4023674 TK.Half.Life NA 2.217 hours 1compartment NA NA Rat Human -DTXSID4023674 Css NA 0.07354 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023674 Css NA 0.5745 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023674 Css NA 0.05879 mg/L PBTK NA 50% Rat Human -DTXSID4023674 Css NA 0.3463 mg/L PBTK NA 95% Rat Human -DTXSID4023676 Clint NA 0.2499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4023674 Css NA 0.01141 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023674 Css NA 0.06929 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023674 Css NA 0.009885 mg/L PBTK NA 50% Rat Human +DTXSID4023674 Css NA 0.06 mg/L PBTK NA 95% Rat Human +DTXSID4023676 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4023676 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4023676 Vd NA 0.763 L/kg 1compartment NA NA Human Human DTXSID4023676 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023676 TK.Half.Life NA 4.418 hours 1compartment NA NA Human Human -DTXSID4023676 Css NA 0.6854 mg/L 3compartmentss NA 50% Human Human -DTXSID4023676 Css NA 4.099 mg/L 3compartmentss NA 95% Human Human -DTXSID4023676 Css NA 0.5656 mg/L PBTK NA 50% Human Human -DTXSID4023676 Css NA 2.665 mg/L PBTK NA 95% Human Human -DTXSID4023676 Clint NA 0.2499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4023676 TK.Half.Life NA 6.189 hours 1compartment NA NA Human Human +DTXSID4023676 Css NA 0.9582 mg/L 3compartmentss NA 50% Human Human +DTXSID4023676 Css NA 5.902 mg/L 3compartmentss NA 95% Human Human +DTXSID4023676 Css NA 0.7902 mg/L PBTK NA 50% Human Human +DTXSID4023676 Css NA 3.793 mg/L PBTK NA 95% Human Human +DTXSID4023676 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4023676 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4023676 Vd NA 0.7837 L/kg 1compartment NA NA Rat Human DTXSID4023676 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023676 TK.Half.Life NA 1.806 hours 1compartment NA NA Rat Human -DTXSID4023676 Css NA 0.2089 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023676 Css NA 1.304 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023676 Css NA 0.1683 mg/L PBTK NA 50% Rat Human -DTXSID4023676 Css NA 0.7755 mg/L PBTK NA 95% Rat Human -DTXSID4023678 Clint NA 3.846 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4023676 TK.Half.Life NA 2.161 hours 1compartment NA NA Rat Human +DTXSID4023676 Css NA 0.05648 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023676 Css NA 0.3355 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023676 Css NA 0.04709 mg/L PBTK NA 50% Rat Human +DTXSID4023676 Css NA 0.2086 mg/L PBTK NA 95% Rat Human +DTXSID4023678 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4023678 Fup 0.45 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4023678 Vd NA 0.4568 L/kg 1compartment NA NA Human Human +DTXSID4023678 Vd NA 0.4946 L/kg 1compartment NA NA Human Human DTXSID4023678 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4023678 TK.Half.Life NA 0.8997 hours 1compartment NA NA Human Human -DTXSID4023678 Css NA 0.167 mg/L 3compartmentss NA 50% Human Human -DTXSID4023678 Css NA 1.159 mg/L 3compartmentss NA 95% Human Human -DTXSID4023678 Css NA 0.1202 mg/L PBTK NA 50% Human Human -DTXSID4023678 Css NA 0.7387 mg/L PBTK NA 95% Human Human -DTXSID4023678 Clint NA 3.846 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4023678 TK.Half.Life NA 7.111 hours 1compartment NA NA Human Human +DTXSID4023678 Css NA 1.382 mg/L 3compartmentss NA 50% Human Human +DTXSID4023678 Css NA 6.566 mg/L 3compartmentss NA 95% Human Human +DTXSID4023678 Css NA 1.02 mg/L PBTK NA 50% Human Human +DTXSID4023678 Css NA 4.159 mg/L PBTK NA 95% Human Human +DTXSID4023678 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4023678 Fup 0.45 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4023678 Vd NA 0.4814 L/kg 1compartment NA NA Rat Human +DTXSID4023678 Vd NA 0.5144 L/kg 1compartment NA NA Rat Human DTXSID4023678 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4023678 TK.Half.Life NA 0.5235 hours 1compartment NA NA Rat Human -DTXSID4023678 Css NA 0.08326 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023678 Css NA 0.4443 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023678 Css NA 0.0574 mg/L PBTK NA 50% Rat Human -DTXSID4023678 Css NA 0.2664 mg/L PBTK NA 95% Rat Human -DTXSID4023701 Clint NA 6.238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023701 Fup NA 0.7822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4023701 Vd NA 3.138 L/kg 1compartment NA NA Human Human -DTXSID4023701 Days.Css NA 60 Days PBTK NA NA Human Human -DTXSID4023701 TK.Half.Life NA 281 hours 1compartment NA NA Human Human -DTXSID4023701 Css NA 10.96 mg/L 3compartmentss NA 50% Human Human -DTXSID4023701 Css NA 67.45 mg/L 3compartmentss NA 95% Human Human -DTXSID4023701 Css NA 7.63 mg/L PBTK NA 50% Human Human -DTXSID4023701 Css NA 45.21 mg/L PBTK NA 95% Human Human -DTXSID4023701 Clint NA 6.238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023701 Fup NA 0.7822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4023701 Vd NA 2.352 L/kg 1compartment NA NA Rat Human -DTXSID4023701 Days.Css NA 33 Days PBTK NA NA Rat Human -DTXSID4023701 TK.Half.Life NA 35.62 hours 1compartment NA NA Rat Human -DTXSID4023701 Css NA 6.162 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023701 Css NA 30.19 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023701 Css NA 4.101 mg/L PBTK NA 50% Rat Human -DTXSID4023701 Css NA 19.54 mg/L PBTK NA 95% Rat Human -DTXSID4023753 Clint NA 14.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4023678 TK.Half.Life NA 2.52 hours 1compartment NA NA Rat Human +DTXSID4023678 Css NA 0.0255 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023678 Css NA 0.164 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023678 Css NA 0.0182 mg/L PBTK NA 50% Rat Human +DTXSID4023678 Css NA 0.1053 mg/L PBTK NA 95% Rat Human +DTXSID4023705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023705 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023705 Vd NA 2.896 L/kg 1compartment NA NA Human Human +DTXSID4023705 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023705 TK.Half.Life NA 3.997 hours 1compartment NA NA Human Human +DTXSID4023705 Css NA 0.08754 mg/L 3compartmentss NA 50% Human Human +DTXSID4023705 Css NA 0.7708 mg/L 3compartmentss NA 95% Human Human +DTXSID4023705 Css NA 0.07344 mg/L PBTK NA 50% Human Human +DTXSID4023705 Css NA 0.5736 mg/L PBTK NA 95% Human Human +DTXSID4023705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023705 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023705 Vd NA 2.608 L/kg 1compartment NA NA Rat Human +DTXSID4023705 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023705 TK.Half.Life NA 1.725 hours 1compartment NA NA Rat Human +DTXSID4023705 Css NA 0.01143 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023705 Css NA 0.07897 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023705 Css NA 0.009538 mg/L PBTK NA 50% Rat Human +DTXSID4023705 Css NA 0.05816 mg/L PBTK NA 95% Rat Human +DTXSID4023753 Clint 15 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID4023753 Fup 0.0012 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4023753 Vd NA 0.5204 L/kg 1compartment NA NA Human Human -DTXSID4023753 Days.Css NA 14 Days PBTK NA NA Human Human -DTXSID4023753 TK.Half.Life NA 68.29 hours 1compartment NA NA Human Human -DTXSID4023753 Css NA 19.35 mg/L 3compartmentss NA 50% Human Human -DTXSID4023753 Css NA 176.4 mg/L 3compartmentss NA 95% Human Human -DTXSID4023753 Css NA 14.79 mg/L PBTK NA 50% Human Human -DTXSID4023753 Css NA 117.5 mg/L PBTK NA 95% Human Human -DTXSID4023753 Clint NA 14.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4023753 Vd NA 0.543 L/kg 1compartment NA NA Human Human +DTXSID4023753 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID4023753 TK.Half.Life NA 67.04 hours 1compartment NA NA Human Human +DTXSID4023753 Css NA 16.65 mg/L 3compartmentss NA 50% Human Human +DTXSID4023753 Css NA 130.9 mg/L 3compartmentss NA 95% Human Human +DTXSID4023753 Css NA 13.49 mg/L PBTK NA 50% Human Human +DTXSID4023753 Css NA 106 mg/L PBTK NA 95% Human Human +DTXSID4023753 Clint 15 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID4023753 Fup 0.0012 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4023753 Vd NA 0.3875 L/kg 1compartment NA NA Rat Human -DTXSID4023753 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID4023753 TK.Half.Life NA 33.57 hours 1compartment NA NA Rat Human -DTXSID4023753 Css NA 10.73 mg/L 3compartmentss NA 50% Rat Human -DTXSID4023753 Css NA 74.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID4023753 Css NA 7.839 mg/L PBTK NA 50% Rat Human -DTXSID4023753 Css NA 46.94 mg/L PBTK NA 95% Rat Human +DTXSID4023753 Vd NA 0.4032 L/kg 1compartment NA NA Rat Human +DTXSID4023753 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4023753 TK.Half.Life NA 32.77 hours 1compartment NA NA Rat Human +DTXSID4023753 Css NA 1.984 mg/L 3compartmentss NA 50% Rat Human +DTXSID4023753 Css NA 12.25 mg/L 3compartmentss NA 95% Rat Human +DTXSID4023753 Css NA 1.661 mg/L PBTK NA 50% Rat Human +DTXSID4023753 Css NA 10.27 mg/L PBTK NA 95% Rat Human +DTXSID40238163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40238163 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40238163 Vd NA 1.62 L/kg 1compartment NA NA Human Human +DTXSID40238163 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40238163 TK.Half.Life NA 2.841 hours 1compartment NA NA Human Human +DTXSID40238163 Css NA 0.1348 mg/L 3compartmentss NA 50% Human Human +DTXSID40238163 Css NA 1.135 mg/L 3compartmentss NA 95% Human Human +DTXSID40238163 Css NA 0.1035 mg/L PBTK NA 50% Human Human +DTXSID40238163 Css NA 0.773 mg/L PBTK NA 95% Human Human +DTXSID40238163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40238163 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40238163 Vd NA 1.594 L/kg 1compartment NA NA Rat Human +DTXSID40238163 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40238163 TK.Half.Life NA 1.603 hours 1compartment NA NA Rat Human +DTXSID40238163 Css NA 0.01682 mg/L 3compartmentss NA 50% Rat Human +DTXSID40238163 Css NA 0.1152 mg/L 3compartmentss NA 95% Rat Human +DTXSID40238163 Css NA 0.01299 mg/L PBTK NA 50% Rat Human +DTXSID40238163 Css NA 0.07644 mg/L PBTK NA 95% Rat Human +DTXSID40238527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40238527 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40238527 Vd NA 2.64 L/kg 1compartment NA NA Human Human +DTXSID40238527 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID40238527 TK.Half.Life NA 81.91 hours 1compartment NA NA Human Human +DTXSID40238527 Css NA 4.332 mg/L 3compartmentss NA 50% Human Human +DTXSID40238527 Css NA 30.98 mg/L 3compartmentss NA 95% Human Human +DTXSID40238527 Css NA 2.868 mg/L PBTK NA 50% Human Human +DTXSID40238527 Css NA 19.46 mg/L PBTK NA 95% Human Human +DTXSID40238527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40238527 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40238527 Vd NA 1.967 L/kg 1compartment NA NA Rat Human +DTXSID40238527 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID40238527 TK.Half.Life NA 17.97 hours 1compartment NA NA Rat Human +DTXSID40238527 Css NA 0.5671 mg/L 3compartmentss NA 50% Rat Human +DTXSID40238527 Css NA 3.376 mg/L 3compartmentss NA 95% Rat Human +DTXSID40238527 Css NA 0.3689 mg/L PBTK NA 50% Rat Human +DTXSID40238527 Css NA 2.136 mg/L PBTK NA 95% Rat Human +DTXSID4023917 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023917 Fup 0.464 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4023917 Vd NA 1.268 L/kg 1compartment NA NA Human Human +DTXSID4023917 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4023917 TK.Half.Life NA 1.311 hours 1compartment NA NA Human Human +DTXSID4023917 Css NA 0.0431 mg/L 3compartmentss NA 50% Human Human +DTXSID4023917 Css NA 0.3449 mg/L 3compartmentss NA 95% Human Human +DTXSID4023917 Css NA 0.03492 mg/L PBTK NA 50% Human Human +DTXSID4023917 Css NA 0.2477 mg/L PBTK NA 95% Human Human +DTXSID4023917 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023917 Fup 0.464 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4023917 Vd 1.2 1.095 L/kg 1compartment National Toxicology Program NA Rat Human +DTXSID4023917 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4023917 TK.Half.Life 0.21 0.559 hours 1compartment National Toxicology Program NA Rat Human +DTXSID4023917 Css 0.011 0.005302 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID4023917 Css 0.011 0.03535 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID4023917 Css 0.011 0.004282 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID4023917 Css 0.011 0.02505 mg/L PBTK National Toxicology Program 95% Rat Human DTXSID4024018 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4024018 Fup 0.1802 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4024018 Vd NA 0.4976 L/kg 1compartment NA NA Human Human DTXSID4024018 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID4024018 TK.Half.Life NA 17.86 hours 1compartment NA NA Human Human -DTXSID4024018 Css NA 4.172 mg/L 3compartmentss NA 50% Human Human -DTXSID4024018 Css NA 15.52 mg/L 3compartmentss NA 95% Human Human -DTXSID4024018 Css NA 2.915 mg/L PBTK NA 50% Human Human -DTXSID4024018 Css NA 9.742 mg/L PBTK NA 95% Human Human +DTXSID4024018 Css NA 4.02 mg/L 3compartmentss NA 50% Human Human +DTXSID4024018 Css NA 14.97 mg/L 3compartmentss NA 95% Human Human +DTXSID4024018 Css NA 2.811 mg/L PBTK NA 50% Human Human +DTXSID4024018 Css NA 9.331 mg/L PBTK NA 95% Human Human DTXSID4024018 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4024018 Fup 0.1802 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4024018 Vd NA 0.4935 L/kg 1compartment NA NA Rat Human DTXSID4024018 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4024018 TK.Half.Life NA 6.038 hours 1compartment NA NA Rat Human -DTXSID4024018 Css NA 1.156 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024018 Css NA 3.558 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024018 Css NA 0.7683 mg/L PBTK NA 50% Rat Human -DTXSID4024018 Css NA 2.085 mg/L PBTK NA 95% Rat Human -DTXSID4024062 Clint NA 5.376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024062 Fup NA 0.3263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024062 Vd NA 1.705 L/kg 1compartment NA NA Human Human +DTXSID4024018 Css NA 0.2594 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024018 Css NA 0.8096 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024018 Css NA 0.1785 mg/L PBTK NA 50% Rat Human +DTXSID4024018 Css NA 0.4912 mg/L PBTK NA 95% Rat Human +DTXSID4024062 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024062 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024062 Vd NA 1.502 L/kg 1compartment NA NA Human Human DTXSID4024062 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024062 TK.Half.Life NA 5.394 hours 1compartment NA NA Human Human -DTXSID4024062 Css NA 0.2973 mg/L 3compartmentss NA 50% Human Human -DTXSID4024062 Css NA 1.67 mg/L 3compartmentss NA 95% Human Human -DTXSID4024062 Css NA 0.2278 mg/L PBTK NA 50% Human Human -DTXSID4024062 Css NA 1.15 mg/L PBTK NA 95% Human Human -DTXSID4024062 Clint NA 5.376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024062 Fup NA 0.3263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024062 Vd NA 1.366 L/kg 1compartment NA NA Rat Human +DTXSID4024062 TK.Half.Life NA 2.328 hours 1compartment NA NA Human Human +DTXSID4024062 Css NA 0.09482 mg/L 3compartmentss NA 50% Human Human +DTXSID4024062 Css NA 0.6868 mg/L 3compartmentss NA 95% Human Human +DTXSID4024062 Css NA 0.06982 mg/L PBTK NA 50% Human Human +DTXSID4024062 Css NA 0.4621 mg/L PBTK NA 95% Human Human +DTXSID4024062 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024062 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024062 Vd NA 1.2 L/kg 1compartment NA NA Rat Human DTXSID4024062 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024062 TK.Half.Life NA 2.046 hours 1compartment NA NA Rat Human -DTXSID4024062 Css NA 0.1474 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024062 Css NA 0.631 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024062 Css NA 0.1102 mg/L PBTK NA 50% Rat Human -DTXSID4024062 Css NA 0.4076 mg/L PBTK NA 95% Rat Human -DTXSID4024064 Clint NA 0.1147 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024064 Fup NA 0.0254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024064 Vd NA 0.3478 L/kg 1compartment NA NA Human Human -DTXSID4024064 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID4024064 TK.Half.Life NA 74.56 hours 1compartment NA NA Human Human -DTXSID4024064 Css NA 34.96 mg/L 3compartmentss NA 50% Human Human -DTXSID4024064 Css NA 221.3 mg/L 3compartmentss NA 95% Human Human -DTXSID4024064 Css NA 21.3 mg/L PBTK NA 50% Human Human -DTXSID4024064 Css NA 128.3 mg/L PBTK NA 95% Human Human -DTXSID4024064 Clint NA 0.1147 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024064 Fup NA 0.0254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024064 Vd NA 0.3077 L/kg 1compartment NA NA Rat Human -DTXSID4024064 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4024064 TK.Half.Life NA 24.42 hours 1compartment NA NA Rat Human -DTXSID4024064 Css NA 11.16 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024064 Css NA 61.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024064 Css NA 6.324 mg/L PBTK NA 50% Rat Human -DTXSID4024064 Css NA 33.57 mg/L PBTK NA 95% Rat Human +DTXSID4024062 TK.Half.Life NA 0.9171 hours 1compartment NA NA Rat Human +DTXSID4024062 Css NA 0.01205 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024062 Css NA 0.06433 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024062 Css NA 0.008878 mg/L PBTK NA 50% Rat Human +DTXSID4024062 Css NA 0.04377 mg/L PBTK NA 95% Rat Human +DTXSID4024064 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024064 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024064 Vd NA 0.2897 L/kg 1compartment NA NA Human Human +DTXSID4024064 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4024064 TK.Half.Life NA 3.362 hours 1compartment NA NA Human Human +DTXSID4024064 Css NA 1.962 mg/L 3compartmentss NA 50% Human Human +DTXSID4024064 Css NA 19.52 mg/L 3compartmentss NA 95% Human Human +DTXSID4024064 Css NA 1.164 mg/L PBTK NA 50% Human Human +DTXSID4024064 Css NA 11.44 mg/L PBTK NA 95% Human Human +DTXSID4024064 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024064 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024064 Vd NA 0.2586 L/kg 1compartment NA NA Rat Human +DTXSID4024064 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4024064 TK.Half.Life NA 1.979 hours 1compartment NA NA Rat Human +DTXSID4024064 Css NA 0.2622 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024064 Css NA 2.051 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024064 Css NA 0.1511 mg/L PBTK NA 50% Rat Human +DTXSID4024064 Css NA 1.158 mg/L PBTK NA 95% Rat Human DTXSID4024066 Clint 24.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4024066 Fup 0.06949 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4024066 Vd NA 0.4912 L/kg 1compartment NA NA Human Human DTXSID4024066 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4024066 TK.Half.Life NA 1.517 hours 1compartment NA NA Human Human -DTXSID4024066 Css NA 0.398 mg/L 3compartmentss NA 50% Human Human -DTXSID4024066 Css NA 3.219 mg/L 3compartmentss NA 95% Human Human -DTXSID4024066 Css NA 0.2463 mg/L PBTK NA 50% Human Human -DTXSID4024066 Css NA 1.895 mg/L PBTK NA 95% Human Human +DTXSID4024066 Css NA 0.3883 mg/L 3compartmentss NA 50% Human Human +DTXSID4024066 Css NA 3.119 mg/L 3compartmentss NA 95% Human Human +DTXSID4024066 Css NA 0.2382 mg/L PBTK NA 50% Human Human +DTXSID4024066 Css NA 1.822 mg/L PBTK NA 95% Human Human DTXSID4024066 Clint 24.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4024066 Fup 0.06949 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4024066 Vd NA 0.4157 L/kg 1compartment NA NA Rat Human DTXSID4024066 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4024066 TK.Half.Life NA 0.7708 hours 1compartment NA NA Rat Human -DTXSID4024066 Css NA 0.2285 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024066 Css NA 1.338 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024066 Css NA 0.1318 mg/L PBTK NA 50% Rat Human -DTXSID4024066 Css NA 0.7551 mg/L PBTK NA 95% Rat Human -DTXSID4024143 Clint NA 1.516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024143 Fup NA 0.8274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024143 Vd NA 0.8479 L/kg 1compartment NA NA Human Human +DTXSID4024066 Css NA 0.05042 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024066 Css NA 0.3142 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024066 Css NA 0.03 mg/L PBTK NA 50% Rat Human +DTXSID4024066 Css NA 0.1821 mg/L PBTK NA 95% Rat Human +DTXSID4024143 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024143 Fup 0.436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024143 Vd NA 0.5676 L/kg 1compartment NA NA Human Human DTXSID4024143 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024143 TK.Half.Life NA 2.157 hours 1compartment NA NA Human Human -DTXSID4024143 Css NA 0.2795 mg/L 3compartmentss NA 50% Human Human -DTXSID4024143 Css NA 1.858 mg/L 3compartmentss NA 95% Human Human -DTXSID4024143 Css NA 0.2341 mg/L PBTK NA 50% Human Human -DTXSID4024143 Css NA 1.255 mg/L PBTK NA 95% Human Human -DTXSID4024143 Clint NA 1.516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024143 Fup NA 0.8274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024143 Vd NA 0.8544 L/kg 1compartment NA NA Rat Human +DTXSID4024143 TK.Half.Life NA 8.45 hours 1compartment NA NA Human Human +DTXSID4024143 Css NA 1.608 mg/L 3compartmentss NA 50% Human Human +DTXSID4024143 Css NA 7.365 mg/L 3compartmentss NA 95% Human Human +DTXSID4024143 Css NA 1.2 mg/L PBTK NA 50% Human Human +DTXSID4024143 Css NA 4.694 mg/L PBTK NA 95% Human Human +DTXSID4024143 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024143 Fup 0.436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024143 Vd NA 0.572 L/kg 1compartment NA NA Rat Human DTXSID4024143 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024143 TK.Half.Life NA 1.094 hours 1compartment NA NA Rat Human -DTXSID4024143 Css NA 0.1119 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024143 Css NA 0.7262 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024143 Css NA 0.09215 mg/L PBTK NA 50% Rat Human -DTXSID4024143 Css NA 0.4434 mg/L PBTK NA 95% Rat Human +DTXSID4024143 TK.Half.Life NA 2.894 hours 1compartment NA NA Rat Human +DTXSID4024143 Css NA 0.1039 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024143 Css NA 0.4107 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024143 Css NA 0.07622 mg/L PBTK NA 50% Rat Human +DTXSID4024143 Css NA 0.251 mg/L PBTK NA 95% Rat Human DTXSID4024145 Clint 6.361 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4024145 Fup 0.613 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4024145 Vd NA 1.758 L/kg 1compartment NA NA Human Human DTXSID4024145 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4024145 TK.Half.Life NA 2.893 hours 1compartment NA NA Human Human -DTXSID4024145 Css NA 0.1248 mg/L 3compartmentss NA 50% Human Human -DTXSID4024145 Css NA 1.02 mg/L 3compartmentss NA 95% Human Human -DTXSID4024145 Css NA 0.1078 mg/L PBTK NA 50% Human Human -DTXSID4024145 Css NA 0.7201 mg/L PBTK NA 95% Human Human +DTXSID4024145 Css NA 0.1187 mg/L 3compartmentss NA 50% Human Human +DTXSID4024145 Css NA 1.033 mg/L 3compartmentss NA 95% Human Human +DTXSID4024145 Css NA 0.1038 mg/L PBTK NA 50% Human Human +DTXSID4024145 Css NA 0.723 mg/L PBTK NA 95% Human Human DTXSID4024145 Clint 6.361 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4024145 Fup 0.613 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4024145 Vd NA 1.481 L/kg 1compartment NA NA Rat Human DTXSID4024145 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4024145 TK.Half.Life NA 1.165 hours 1compartment NA NA Rat Human -DTXSID4024145 Css NA 0.06077 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024145 Css NA 0.4275 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024145 Css NA 0.05165 mg/L PBTK NA 50% Rat Human -DTXSID4024145 Css NA 0.2784 mg/L PBTK NA 95% Rat Human -DTXSID4024193 Clint NA 2.387 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024193 Fup NA 0.0297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024193 Vd NA 0.286 L/kg 1compartment NA NA Human Human -DTXSID4024193 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4024193 TK.Half.Life NA 12.72 hours 1compartment NA NA Human Human -DTXSID4024193 Css NA 7.838 mg/L 3compartmentss NA 50% Human Human -DTXSID4024193 Css NA 59.04 mg/L 3compartmentss NA 95% Human Human -DTXSID4024193 Css NA 4.785 mg/L PBTK NA 50% Human Human -DTXSID4024193 Css NA 34.17 mg/L PBTK NA 95% Human Human -DTXSID4024193 Clint NA 2.387 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024193 Fup NA 0.0297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024193 Vd NA 0.2772 L/kg 1compartment NA NA Rat Human +DTXSID4024145 Css NA 0.01353 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024145 Css NA 0.09778 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024145 Css NA 0.01186 mg/L PBTK NA 50% Rat Human +DTXSID4024145 Css NA 0.065 mg/L PBTK NA 95% Rat Human +DTXSID4024193 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024193 Fup 0.0655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024193 Vd NA 0.3445 L/kg 1compartment NA NA Human Human +DTXSID4024193 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4024193 TK.Half.Life NA 1.214 hours 1compartment NA NA Human Human +DTXSID4024193 Css NA 0.428 mg/L 3compartmentss NA 50% Human Human +DTXSID4024193 Css NA 3.155 mg/L 3compartmentss NA 95% Human Human +DTXSID4024193 Css NA 0.2704 mg/L PBTK NA 50% Human Human +DTXSID4024193 Css NA 1.913 mg/L PBTK NA 95% Human Human +DTXSID4024193 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024193 Fup 0.0655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024193 Vd NA 0.337 L/kg 1compartment NA NA Rat Human DTXSID4024193 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024193 TK.Half.Life NA 7.079 hours 1compartment NA NA Rat Human -DTXSID4024193 Css NA 3.743 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024193 Css NA 23.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024193 Css NA 2.122 mg/L PBTK NA 50% Rat Human -DTXSID4024193 Css NA 12.69 mg/L PBTK NA 95% Rat Human +DTXSID4024193 TK.Half.Life NA 0.7336 hours 1compartment NA NA Rat Human +DTXSID4024193 Css NA 0.0558 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024193 Css NA 0.3239 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024193 Css NA 0.03399 mg/L PBTK NA 50% Rat Human +DTXSID4024193 Css NA 0.1902 mg/L PBTK NA 95% Rat Human DTXSID4024195 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4024195 Fup 0.01797 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4024195 Vd NA 0.2386 L/kg 1compartment NA NA Human Human DTXSID4024195 Days.Css NA 22 Days PBTK NA NA Human Human DTXSID4024195 TK.Half.Life NA 85.96 hours 1compartment NA NA Human Human -DTXSID4024195 Css NA 32.39 mg/L 3compartmentss NA 50% Human Human -DTXSID4024195 Css NA 305.2 mg/L 3compartmentss NA 95% Human Human -DTXSID4024195 Css NA 36.54 mg/L PBTK NA 50% Human Human -DTXSID4024195 Css NA 218.4 mg/L PBTK NA 95% Human Human +DTXSID4024195 Css NA 27.51 mg/L 3compartmentss NA 50% Human Human +DTXSID4024195 Css NA 159 mg/L 3compartmentss NA 95% Human Human +DTXSID4024195 Css NA 35.76 mg/L PBTK NA 50% Human Human +DTXSID4024195 Css NA 206.7 mg/L PBTK NA 95% Human Human DTXSID4024195 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4024195 Fup 0.01714 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4024195 Vd NA 0.2283 L/kg 1compartment NA NA Rat Rat DTXSID4024195 Days.Css NA 5 Days PBTK NA NA Rat Rat DTXSID4024195 TK.Half.Life NA 29.37 hours 1compartment NA NA Rat Rat -DTXSID4024195 Css NA 9.054 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4024195 Css NA 80.01 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4024195 Css NA 10.2 mg/L PBTK NA 50% Rat Rat -DTXSID4024195 Css NA 52.35 mg/L PBTK NA 95% Rat Rat +DTXSID4024195 Css NA 1.754 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4024195 Css NA 9.364 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4024195 Css NA 2.36 mg/L PBTK NA 50% Rat Rat +DTXSID4024195 Css NA 12.61 mg/L PBTK NA 95% Rat Rat DTXSID4024222 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4024222 Fup NA 0.9675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024222 Vd NA 0.7952 L/kg 1compartment NA NA Human Human +DTXSID4024222 Vd NA 0.8008 L/kg 1compartment NA NA Human Human DTXSID4024222 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024222 TK.Half.Life NA 5.32 hours 1compartment NA NA Human Human -DTXSID4024222 Css NA 0.8817 mg/L 3compartmentss NA 50% Human Human -DTXSID4024222 Css NA 5.125 mg/L 3compartmentss NA 95% Human Human -DTXSID4024222 Css NA 0.7392 mg/L PBTK NA 50% Human Human -DTXSID4024222 Css NA 3.346 mg/L PBTK NA 95% Human Human +DTXSID4024222 TK.Half.Life NA 5.357 hours 1compartment NA NA Human Human +DTXSID4024222 Css NA 0.7468 mg/L 3compartmentss NA 50% Human Human +DTXSID4024222 Css NA 4.209 mg/L 3compartmentss NA 95% Human Human +DTXSID4024222 Css NA 0.627 mg/L PBTK NA 50% Human Human +DTXSID4024222 Css NA 2.786 mg/L PBTK NA 95% Human Human DTXSID4024222 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4024222 Fup NA 0.9675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024222 Vd NA 0.8285 L/kg 1compartment NA NA Rat Human +DTXSID4024222 Vd NA 0.8344 L/kg 1compartment NA NA Rat Human DTXSID4024222 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024222 TK.Half.Life NA 1.889 hours 1compartment NA NA Rat Human -DTXSID4024222 Css NA 0.2246 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024222 Css NA 1.244 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024222 Css NA 0.1831 mg/L PBTK NA 50% Rat Human -DTXSID4024222 Css NA 0.7549 mg/L PBTK NA 95% Rat Human +DTXSID4024222 TK.Half.Life NA 1.902 hours 1compartment NA NA Rat Human +DTXSID4024222 Css NA 0.01394 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024222 Css NA 0.1015 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024222 Css NA 0.01128 mg/L PBTK NA 50% Rat Human +DTXSID4024222 Css NA 0.06713 mg/L PBTK NA 95% Rat Human DTXSID4024270 Clint 16.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4024270 Fup 0.02237 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4024270 Vd NA 2.44 L/kg 1compartment NA NA Human Human DTXSID4024270 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID4024270 TK.Half.Life NA 35.67 hours 1compartment NA NA Human Human -DTXSID4024270 Css NA 2.101 mg/L 3compartmentss NA 50% Human Human -DTXSID4024270 Css NA 15.15 mg/L 3compartmentss NA 95% Human Human -DTXSID4024270 Css NA 1.392 mg/L PBTK NA 50% Human Human -DTXSID4024270 Css NA 9.554 mg/L PBTK NA 95% Human Human +DTXSID4024270 Css NA 2.072 mg/L 3compartmentss NA 50% Human Human +DTXSID4024270 Css NA 15.53 mg/L 3compartmentss NA 95% Human Human +DTXSID4024270 Css NA 1.366 mg/L PBTK NA 50% Human Human +DTXSID4024270 Css NA 9.864 mg/L PBTK NA 95% Human Human DTXSID4024270 Clint 16.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4024270 Fup 0.02237 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4024270 Vd NA 1.82 L/kg 1compartment NA NA Rat Human DTXSID4024270 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID4024270 TK.Half.Life NA 9.095 hours 1compartment NA NA Rat Human -DTXSID4024270 Css NA 1.174 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024270 Css NA 6.881 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024270 Css NA 0.7336 mg/L PBTK NA 50% Rat Human -DTXSID4024270 Css NA 4.171 mg/L PBTK NA 95% Rat Human +DTXSID4024270 Css NA 0.2674 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024270 Css NA 1.629 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024270 Css NA 0.1739 mg/L PBTK NA 50% Rat Human +DTXSID4024270 Css NA 1.024 mg/L PBTK NA 95% Rat Human DTXSID4024272 Clint 35.78 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID4024272 Fup NA 0.0888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024272 Vd NA 2.492 L/kg 1compartment NA NA Human Human +DTXSID4024272 Fup 0.026 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024272 Vd NA 1.719 L/kg 1compartment NA NA Human Human DTXSID4024272 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024272 TK.Half.Life NA 8.034 hours 1compartment NA NA Human Human -DTXSID4024272 Css NA 0.3422 mg/L 3compartmentss NA 50% Human Human -DTXSID4024272 Css NA 2.332 mg/L 3compartmentss NA 95% Human Human -DTXSID4024272 Css NA 0.2348 mg/L PBTK NA 50% Human Human -DTXSID4024272 Css NA 1.528 mg/L PBTK NA 95% Human Human +DTXSID4024272 TK.Half.Life NA 8.925 hours 1compartment NA NA Human Human +DTXSID4024272 Css NA 0.7134 mg/L 3compartmentss NA 50% Human Human +DTXSID4024272 Css NA 6.126 mg/L 3compartmentss NA 95% Human Human +DTXSID4024272 Css NA 0.4534 mg/L PBTK NA 50% Human Human +DTXSID4024272 Css NA 3.758 mg/L PBTK NA 95% Human Human DTXSID4024272 Clint 35.78 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID4024272 Fup NA 0.0888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024272 Vd NA 1.877 L/kg 1compartment NA NA Rat Human +DTXSID4024272 Fup 0.026 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024272 Vd NA 1.279 L/kg 1compartment NA NA Rat Human DTXSID4024272 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024272 TK.Half.Life NA 2.173 hours 1compartment NA NA Rat Human -DTXSID4024272 Css NA 0.1914 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024272 Css NA 1.059 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024272 Css NA 0.125 mg/L PBTK NA 50% Rat Human -DTXSID4024272 Css NA 0.6685 mg/L PBTK NA 95% Rat Human +DTXSID4024272 TK.Half.Life NA 3.208 hours 1compartment NA NA Rat Human +DTXSID4024272 Css NA 0.0941 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024272 Css NA 0.6828 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024272 Css NA 0.05836 mg/L PBTK NA 50% Rat Human +DTXSID4024272 Css NA 0.4005 mg/L PBTK NA 95% Rat Human DTXSID4024274 Clint 69.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4024274 Fup 0.345 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4024274 Vd NA 1.685 L/kg 1compartment NA NA Human Human DTXSID4024274 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4024274 TK.Half.Life NA 1.505 hours 1compartment NA NA Human Human -DTXSID4024274 Css NA 0.02201 mg/L 3compartmentss NA 50% Human Human -DTXSID4024274 Css NA 0.1415 mg/L 3compartmentss NA 95% Human Human -DTXSID4024274 Css NA 0.01713 mg/L PBTK NA 50% Human Human -DTXSID4024274 Css NA 0.105 mg/L PBTK NA 95% Human Human +DTXSID4024274 Css NA 0.01971 mg/L 3compartmentss NA 50% Human Human +DTXSID4024274 Css NA 0.1368 mg/L 3compartmentss NA 95% Human Human +DTXSID4024274 Css NA 0.01547 mg/L PBTK NA 50% Human Human +DTXSID4024274 Css NA 0.1016 mg/L PBTK NA 95% Human Human DTXSID4024274 Clint 69.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4024274 Fup 0.345 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4024274 Vd NA 1.357 L/kg 1compartment NA NA Rat Human DTXSID4024274 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4024274 TK.Half.Life NA 0.5492 hours 1compartment NA NA Rat Human -DTXSID4024274 Css NA 0.012 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024274 Css NA 0.0633 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024274 Css NA 0.00902 mg/L PBTK NA 50% Rat Human -DTXSID4024274 Css NA 0.04585 mg/L PBTK NA 95% Rat Human +DTXSID4024274 Css NA 0.002511 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024274 Css NA 0.01431 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024274 Css NA 0.001969 mg/L PBTK NA 50% Rat Human +DTXSID4024274 Css NA 0.01087 mg/L PBTK NA 95% Rat Human DTXSID4024276 Clint 24 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4024276 Fup 0.0133 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4024276 Vd NA 2.946 L/kg 1compartment NA NA Human Human DTXSID4024276 Days.Css NA 8 Days PBTK NA NA Human Human DTXSID4024276 TK.Half.Life NA 56.96 hours 1compartment NA NA Human Human -DTXSID4024276 Css NA 2.399 mg/L 3compartmentss NA 50% Human Human -DTXSID4024276 Css NA 15.75 mg/L 3compartmentss NA 95% Human Human -DTXSID4024276 Css NA 1.638 mg/L PBTK NA 50% Human Human -DTXSID4024276 Css NA 10.44 mg/L PBTK NA 95% Human Human +DTXSID4024276 Css NA 2.312 mg/L 3compartmentss NA 50% Human Human +DTXSID4024276 Css NA 15.03 mg/L 3compartmentss NA 95% Human Human +DTXSID4024276 Css NA 1.59 mg/L PBTK NA 50% Human Human +DTXSID4024276 Css NA 9.941 mg/L PBTK NA 95% Human Human DTXSID4024276 Clint 24 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4024276 Fup 0.0133 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4024276 Vd NA 2.204 L/kg 1compartment NA NA Rat Human DTXSID4024276 Days.Css NA 4 Days PBTK NA NA Rat Human DTXSID4024276 TK.Half.Life NA 9.62 hours 1compartment NA NA Rat Human -DTXSID4024276 Css NA 1.335 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024276 Css NA 7.116 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024276 Css NA 0.8722 mg/L PBTK NA 50% Rat Human -DTXSID4024276 Css NA 4.535 mg/L PBTK NA 95% Rat Human +DTXSID4024276 Css NA 0.3014 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024276 Css NA 1.716 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024276 Css NA 0.2041 mg/L PBTK NA 50% Rat Human +DTXSID4024276 Css NA 1.152 mg/L PBTK NA 95% Rat Human DTXSID4024303 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4024303 Fup NA 0.6936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024303 Vd NA 1.195 L/kg 1compartment NA NA Human Human +DTXSID4024303 Vd NA 1.456 L/kg 1compartment NA NA Human Human DTXSID4024303 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4024303 TK.Half.Life NA 11.18 hours 1compartment NA NA Human Human -DTXSID4024303 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human -DTXSID4024303 Css NA 7.102 mg/L 3compartmentss NA 95% Human Human -DTXSID4024303 Css NA 0.8886 mg/L PBTK NA 50% Human Human -DTXSID4024303 Css NA 4.622 mg/L PBTK NA 95% Human Human +DTXSID4024303 TK.Half.Life NA 13.74 hours 1compartment NA NA Human Human +DTXSID4024303 Css NA 0.8294 mg/L 3compartmentss NA 50% Human Human +DTXSID4024303 Css NA 6.174 mg/L 3compartmentss NA 95% Human Human +DTXSID4024303 Css NA 0.7602 mg/L PBTK NA 50% Human Human +DTXSID4024303 Css NA 4.113 mg/L PBTK NA 95% Human Human DTXSID4024303 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4024303 Fup NA 0.6936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024303 Vd NA 1.208 L/kg 1compartment NA NA Rat Human +DTXSID4024303 Vd NA 1.456 L/kg 1compartment NA NA Rat Human DTXSID4024303 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024303 TK.Half.Life NA 3.842 hours 1compartment NA NA Rat Human -DTXSID4024303 Css NA 0.2627 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024303 Css NA 1.712 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024303 Css NA 0.2234 mg/L PBTK NA 50% Rat Human -DTXSID4024303 Css NA 1.039 mg/L PBTK NA 95% Rat Human +DTXSID4024303 TK.Half.Life NA 4.64 hours 1compartment NA NA Rat Human +DTXSID4024303 Css NA 0.0157 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024303 Css NA 0.1409 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024303 Css NA 0.01393 mg/L PBTK NA 50% Rat Human +DTXSID4024303 Css NA 0.0947 mg/L PBTK NA 95% Rat Human DTXSID4024359 Clint 26.24 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4024359 Fup 0.005322 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4024359 Vd NA 1.513 L/kg 1compartment NA NA Human Human DTXSID4024359 Days.Css NA 5 Days PBTK NA NA Human Human DTXSID4024359 TK.Half.Life NA 32.8 hours 1compartment NA NA Human Human -DTXSID4024359 Css NA 2.46 mg/L 3compartmentss NA 50% Human Human -DTXSID4024359 Css NA 31.02 mg/L 3compartmentss NA 95% Human Human -DTXSID4024359 Css NA 2.356 mg/L PBTK NA 50% Human Human -DTXSID4024359 Css NA 22.85 mg/L PBTK NA 95% Human Human +DTXSID4024359 Css NA 2.423 mg/L 3compartmentss NA 50% Human Human +DTXSID4024359 Css NA 31.42 mg/L 3compartmentss NA 95% Human Human +DTXSID4024359 Css NA 2.314 mg/L PBTK NA 50% Human Human +DTXSID4024359 Css NA 22.97 mg/L PBTK NA 95% Human Human DTXSID4024359 Clint 60.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4024359 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID4024359 Css NA 0.5706 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4024359 Css NA 4.738 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4024359 Css NA 0.1498 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4024359 Css NA 1.678 mg/L 3compartmentss NA 95% Rat Rat DTXSID4024436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4024436 Fup 0.0137 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4024436 Vd NA 0.2032 L/kg 1compartment NA NA Human Human -DTXSID4024436 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID4024436 TK.Half.Life NA 95.95 hours 1compartment NA NA Human Human -DTXSID4024436 Css NA 55.26 mg/L 3compartmentss NA 50% Human Human -DTXSID4024436 Css NA 266.2 mg/L 3compartmentss NA 95% Human Human -DTXSID4024436 Css NA 32.89 mg/L PBTK NA 50% Human Human -DTXSID4024436 Css NA 153.6 mg/L PBTK NA 95% Human Human +DTXSID4024436 Vd NA 0.1738 L/kg 1compartment NA NA Human Human +DTXSID4024436 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID4024436 TK.Half.Life NA 82.07 hours 1compartment NA NA Human Human +DTXSID4024436 Css NA 29.86 mg/L 3compartmentss NA 50% Human Human +DTXSID4024436 Css NA 150.8 mg/L 3compartmentss NA 95% Human Human +DTXSID4024436 Css NA 17.45 mg/L PBTK NA 50% Human Human +DTXSID4024436 Css NA 87.12 mg/L PBTK NA 95% Human Human DTXSID4024436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4024436 Fup 0.0137 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4024436 Vd NA 0.1994 L/kg 1compartment NA NA Rat Human -DTXSID4024436 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID4024436 TK.Half.Life NA 32.09 hours 1compartment NA NA Rat Human -DTXSID4024436 Css NA 15.66 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024436 Css NA 62.99 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024436 Css NA 8.646 mg/L PBTK NA 50% Rat Human -DTXSID4024436 Css NA 34.2 mg/L PBTK NA 95% Rat Human -DTXSID4024484 Clint NA 51.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024484 Fup NA 0.2973 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024484 Vd NA 0.9843 L/kg 1compartment NA NA Human Human +DTXSID4024436 Vd NA 0.1727 L/kg 1compartment NA NA Rat Human +DTXSID4024436 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID4024436 TK.Half.Life NA 27.79 hours 1compartment NA NA Rat Human +DTXSID4024436 Css NA 0.1653 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024436 Css NA 0.8125 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024436 Css NA 0.09034 mg/L PBTK NA 50% Rat Human +DTXSID4024436 Css NA 0.4425 mg/L PBTK NA 95% Rat Human +DTXSID4024484 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024484 Fup 0.227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024484 Vd NA 0.9604 L/kg 1compartment NA NA Human Human DTXSID4024484 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024484 TK.Half.Life NA 0.9686 hours 1compartment NA NA Human Human -DTXSID4024484 Css NA 0.03126 mg/L 3compartmentss NA 50% Human Human -DTXSID4024484 Css NA 0.2419 mg/L 3compartmentss NA 95% Human Human -DTXSID4024484 Css NA 0.02293 mg/L PBTK NA 50% Human Human -DTXSID4024484 Css NA 0.1659 mg/L PBTK NA 95% Human Human -DTXSID4024484 Clint NA 51.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024484 Fup NA 0.2973 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024484 Vd NA 0.8473 L/kg 1compartment NA NA Rat Human +DTXSID4024484 TK.Half.Life NA 1.479 hours 1compartment NA NA Human Human +DTXSID4024484 Css NA 0.09364 mg/L 3compartmentss NA 50% Human Human +DTXSID4024484 Css NA 0.6586 mg/L 3compartmentss NA 95% Human Human +DTXSID4024484 Css NA 0.0663 mg/L PBTK NA 50% Human Human +DTXSID4024484 Css NA 0.4382 mg/L PBTK NA 95% Human Human +DTXSID4024484 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024484 Fup 0.227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024484 Vd NA 0.8077 L/kg 1compartment NA NA Rat Human DTXSID4024484 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024484 TK.Half.Life NA 0.4039 hours 1compartment NA NA Rat Human -DTXSID4024484 Css NA 0.01729 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024484 Css NA 0.1038 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024484 Css NA 0.01218 mg/L PBTK NA 50% Rat Human -DTXSID4024484 Css NA 0.06609 mg/L PBTK NA 95% Rat Human -DTXSID4024488 Clint NA 30.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024488 Fup NA 0.6358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024488 Vd NA 1.153 L/kg 1compartment NA NA Human Human +DTXSID4024484 TK.Half.Life NA 0.6601 hours 1compartment NA NA Rat Human +DTXSID4024484 Css NA 0.0121 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024484 Css NA 0.06866 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024484 Css NA 0.008478 mg/L PBTK NA 50% Rat Human +DTXSID4024484 Css NA 0.04393 mg/L PBTK NA 95% Rat Human +DTXSID4024488 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024488 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024488 Vd NA 0.9953 L/kg 1compartment NA NA Human Human DTXSID4024488 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024488 TK.Half.Life NA 0.9049 hours 1compartment NA NA Human Human -DTXSID4024488 Css NA 0.02367 mg/L 3compartmentss NA 50% Human Human -DTXSID4024488 Css NA 0.2754 mg/L 3compartmentss NA 95% Human Human -DTXSID4024488 Css NA 0.02033 mg/L PBTK NA 50% Human Human -DTXSID4024488 Css NA 0.192 mg/L PBTK NA 95% Human Human -DTXSID4024488 Clint NA 30.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024488 Fup NA 0.6358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024488 Vd NA 1.058 L/kg 1compartment NA NA Rat Human +DTXSID4024488 TK.Half.Life NA 0.9759 hours 1compartment NA NA Human Human +DTXSID4024488 Css NA 0.03789 mg/L 3compartmentss NA 50% Human Human +DTXSID4024488 Css NA 0.349 mg/L 3compartmentss NA 95% Human Human +DTXSID4024488 Css NA 0.03064 mg/L PBTK NA 50% Human Human +DTXSID4024488 Css NA 0.2373 mg/L PBTK NA 95% Human Human +DTXSID4024488 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024488 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024488 Vd NA 0.9125 L/kg 1compartment NA NA Rat Human DTXSID4024488 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024488 TK.Half.Life NA 0.3965 hours 1compartment NA NA Rat Human -DTXSID4024488 Css NA 0.01226 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024488 Css NA 0.1162 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024488 Css NA 0.01023 mg/L PBTK NA 50% Rat Human -DTXSID4024488 Css NA 0.07783 mg/L PBTK NA 95% Rat Human -DTXSID4024515 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024515 Fup NA 0.3934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024515 Vd NA 0.443 L/kg 1compartment NA NA Human Human -DTXSID4024515 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024515 TK.Half.Life NA 7.285 hours 1compartment NA NA Human Human -DTXSID4024515 Css NA 1.89 mg/L 3compartmentss NA 50% Human Human -DTXSID4024515 Css NA 8.172 mg/L 3compartmentss NA 95% Human Human -DTXSID4024515 Css NA 1.352 mg/L PBTK NA 50% Human Human -DTXSID4024515 Css NA 5.126 mg/L PBTK NA 95% Human Human -DTXSID4024515 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024515 Fup NA 0.3934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024515 Vd NA 0.4597 L/kg 1compartment NA NA Rat Human -DTXSID4024515 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024515 TK.Half.Life NA 2.576 hours 1compartment NA NA Rat Human -DTXSID4024515 Css NA 0.5226 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024515 Css NA 1.896 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024515 Css NA 0.3554 mg/L PBTK NA 50% Rat Human -DTXSID4024515 Css NA 1.109 mg/L PBTK NA 95% Rat Human +DTXSID4024488 TK.Half.Life NA 0.4481 hours 1compartment NA NA Rat Human +DTXSID4024488 Css NA 0.004636 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024488 Css NA 0.03541 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024488 Css NA 0.003777 mg/L PBTK NA 50% Rat Human +DTXSID4024488 Css NA 0.02419 mg/L PBTK NA 95% Rat Human DTXSID4024642 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4024642 Fup NA 0.5024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024642 Vd NA 0.7155 L/kg 1compartment NA NA Human Human +DTXSID4024642 Vd NA 0.7224 L/kg 1compartment NA NA Human Human DTXSID4024642 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024642 TK.Half.Life NA 9.215 hours 1compartment NA NA Human Human -DTXSID4024642 Css NA 1.353 mg/L 3compartmentss NA 50% Human Human -DTXSID4024642 Css NA 7.581 mg/L 3compartmentss NA 95% Human Human -DTXSID4024642 Css NA 1.103 mg/L PBTK NA 50% Human Human -DTXSID4024642 Css NA 4.914 mg/L PBTK NA 95% Human Human +DTXSID4024642 TK.Half.Life NA 9.304 hours 1compartment NA NA Human Human +DTXSID4024642 Css NA 1.148 mg/L 3compartmentss NA 50% Human Human +DTXSID4024642 Css NA 6.34 mg/L 3compartmentss NA 95% Human Human +DTXSID4024642 Css NA 0.9456 mg/L PBTK NA 50% Human Human +DTXSID4024642 Css NA 4.179 mg/L PBTK NA 95% Human Human DTXSID4024642 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4024642 Fup NA 0.5024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024642 Vd NA 0.7249 L/kg 1compartment NA NA Rat Human +DTXSID4024642 Vd 0.86 0.7315 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID4024642 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024642 TK.Half.Life NA 3.182 hours 1compartment NA NA Rat Human -DTXSID4024642 Css NA 0.3648 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024642 Css NA 1.735 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024642 Css NA 0.2866 mg/L PBTK NA 50% Rat Human -DTXSID4024642 Css NA 1.053 mg/L PBTK NA 95% Rat Human +DTXSID4024642 TK.Half.Life 0.21 3.211 hours 1compartment National Toxicology Program NA Rat Human +DTXSID4024642 Css 0.015 0.021 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID4024642 Css 0.015 0.1609 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID4024642 Css 0.015 0.01678 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID4024642 Css 0.015 0.1063 mg/L PBTK National Toxicology Program 95% Rat Human DTXSID4024644 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4024644 Fup NA 0.3224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4024644 Vd NA 0.5978 L/kg 1compartment NA NA Human Human DTXSID4024644 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID4024644 TK.Half.Life NA 12 hours 1compartment NA NA Human Human -DTXSID4024644 Css NA 2.205 mg/L 3compartmentss NA 50% Human Human -DTXSID4024644 Css NA 9.312 mg/L 3compartmentss NA 95% Human Human -DTXSID4024644 Css NA 1.648 mg/L PBTK NA 50% Human Human -DTXSID4024644 Css NA 5.924 mg/L PBTK NA 95% Human Human +DTXSID4024644 Css NA 1.852 mg/L 3compartmentss NA 50% Human Human +DTXSID4024644 Css NA 7.944 mg/L 3compartmentss NA 95% Human Human +DTXSID4024644 Css NA 1.402 mg/L PBTK NA 50% Human Human +DTXSID4024644 Css NA 5.164 mg/L PBTK NA 95% Human Human DTXSID4024644 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4024644 Fup NA 0.3224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4024644 Vd NA 0.6013 L/kg 1compartment NA NA Rat Human DTXSID4024644 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4024644 TK.Half.Life NA 4.111 hours 1compartment NA NA Rat Human -DTXSID4024644 Css NA 0.6037 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024644 Css NA 2.137 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024644 Css NA 0.4331 mg/L PBTK NA 50% Rat Human -DTXSID4024644 Css NA 1.282 mg/L PBTK NA 95% Rat Human -DTXSID4024646 Clint NA 2.407 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024646 Fup NA 0.2741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024646 Vd NA 1.116 L/kg 1compartment NA NA Human Human +DTXSID4024644 Css NA 0.03374 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024644 Css NA 0.2046 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024644 Css NA 0.02469 mg/L PBTK NA 50% Rat Human +DTXSID4024644 Css NA 0.1333 mg/L PBTK NA 95% Rat Human +DTXSID4024646 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024646 Fup 0.0736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024646 Vd NA 0.5546 L/kg 1compartment NA NA Human Human DTXSID4024646 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024646 TK.Half.Life NA 6.25 hours 1compartment NA NA Human Human -DTXSID4024646 Css NA 0.5954 mg/L 3compartmentss NA 50% Human Human -DTXSID4024646 Css NA 2.859 mg/L 3compartmentss NA 95% Human Human -DTXSID4024646 Css NA 0.4402 mg/L PBTK NA 50% Human Human -DTXSID4024646 Css NA 1.919 mg/L PBTK NA 95% Human Human -DTXSID4024646 Clint NA 2.407 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024646 Fup NA 0.2741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024646 Vd NA 0.9328 L/kg 1compartment NA NA Rat Human +DTXSID4024646 TK.Half.Life NA 4.643 hours 1compartment NA NA Human Human +DTXSID4024646 Css NA 1.27 mg/L 3compartmentss NA 50% Human Human +DTXSID4024646 Css NA 8.548 mg/L 3compartmentss NA 95% Human Human +DTXSID4024646 Css NA 0.7904 mg/L PBTK NA 50% Human Human +DTXSID4024646 Css NA 5.062 mg/L PBTK NA 95% Human Human +DTXSID4024646 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024646 Fup 0.0736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024646 Vd NA 0.4614 L/kg 1compartment NA NA Rat Human DTXSID4024646 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024646 TK.Half.Life NA 2.677 hours 1compartment NA NA Rat Human -DTXSID4024646 Css NA 0.277 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024646 Css NA 1.017 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024646 Css NA 0.1966 mg/L PBTK NA 50% Rat Human -DTXSID4024646 Css NA 0.6227 mg/L PBTK NA 95% Rat Human +DTXSID4024646 TK.Half.Life NA 2.338 hours 1compartment NA NA Rat Human +DTXSID4024646 Css NA 0.1563 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024646 Css NA 0.8052 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024646 Css NA 0.09408 mg/L PBTK NA 50% Rat Human +DTXSID4024646 Css NA 0.4621 mg/L PBTK NA 95% Rat Human +DTXSID4024692 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024692 Fup 0.634 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024692 Vd NA 1.455 L/kg 1compartment NA NA Human Human +DTXSID4024692 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4024692 TK.Half.Life NA 17.29 hours 1compartment NA NA Human Human +DTXSID4024692 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human +DTXSID4024692 Css NA 6.712 mg/L 3compartmentss NA 95% Human Human +DTXSID4024692 Css NA 0.8918 mg/L PBTK NA 50% Human Human +DTXSID4024692 Css NA 4.439 mg/L PBTK NA 95% Human Human +DTXSID4024692 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024692 Fup 0.634 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024692 Vd NA 1.269 L/kg 1compartment NA NA Rat Human +DTXSID4024692 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4024692 TK.Half.Life NA 4.587 hours 1compartment NA NA Rat Human +DTXSID4024692 Css NA 0.01879 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024692 Css NA 0.1638 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024692 Css NA 0.01602 mg/L PBTK NA 50% Rat Human +DTXSID4024692 Css NA 0.1084 mg/L PBTK NA 95% Rat Human +DTXSID4024721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024721 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024721 Vd NA 1.698 L/kg 1compartment NA NA Human Human +DTXSID4024721 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4024721 TK.Half.Life NA 2.769 hours 1compartment NA NA Human Human +DTXSID4024721 Css NA 0.1074 mg/L 3compartmentss NA 50% Human Human +DTXSID4024721 Css NA 0.7141 mg/L 3compartmentss NA 95% Human Human +DTXSID4024721 Css NA 0.07867 mg/L PBTK NA 50% Human Human +DTXSID4024721 Css NA 0.4953 mg/L PBTK NA 95% Human Human +DTXSID4024721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024721 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024721 Vd NA 1.338 L/kg 1compartment NA NA Rat Human +DTXSID4024721 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4024721 TK.Half.Life NA 1.039 hours 1compartment NA NA Rat Human +DTXSID4024721 Css NA 0.01321 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024721 Css NA 0.06809 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024721 Css NA 0.009702 mg/L PBTK NA 50% Rat Human +DTXSID4024721 Css NA 0.04741 mg/L PBTK NA 95% Rat Human DTXSID4024729 Clint 24 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4024729 Fup 0.4872 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4024729 Vd NA 1.23 L/kg 1compartment NA NA Human Human DTXSID4024729 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4024729 TK.Half.Life NA 1.118 hours 1compartment NA NA Human Human -DTXSID4024729 Css NA 0.0374 mg/L 3compartmentss NA 50% Human Human -DTXSID4024729 Css NA 0.3151 mg/L 3compartmentss NA 95% Human Human -DTXSID4024729 Css NA 0.03231 mg/L PBTK NA 50% Human Human -DTXSID4024729 Css NA 0.2331 mg/L PBTK NA 95% Human Human +DTXSID4024729 Css NA 0.03245 mg/L 3compartmentss NA 50% Human Human +DTXSID4024729 Css NA 0.2531 mg/L 3compartmentss NA 95% Human Human +DTXSID4024729 Css NA 0.02957 mg/L PBTK NA 50% Human Human +DTXSID4024729 Css NA 0.2314 mg/L PBTK NA 95% Human Human DTXSID4024729 Clint 31.7 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4024729 Fup 0.3805 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID4024729 Vd NA 0.9325 L/kg 1compartment NA NA Rat Rat DTXSID4024729 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4024729 TK.Half.Life NA 0.4224 hours 1compartment NA NA Rat Rat -DTXSID4024729 Css NA 0.01818 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4024729 Css NA 0.116 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4024729 Css NA 0.01556 mg/L PBTK NA 50% Rat Rat -DTXSID4024729 Css NA 0.08467 mg/L PBTK NA 95% Rat Rat -DTXSID4024771 Clint NA 0.2112 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024771 Fup NA 0.0744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024771 Vd NA 0.3209 L/kg 1compartment NA NA Human Human -DTXSID4024771 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4024771 TK.Half.Life NA 20.69 hours 1compartment NA NA Human Human -DTXSID4024771 Css NA 10 mg/L 3compartmentss NA 50% Human Human -DTXSID4024771 Css NA 46.55 mg/L 3compartmentss NA 95% Human Human -DTXSID4024771 Css NA 6.204 mg/L PBTK NA 50% Human Human -DTXSID4024771 Css NA 27.28 mg/L PBTK NA 95% Human Human -DTXSID4024771 Clint NA 0.2112 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024771 Fup NA 0.0744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024771 Vd NA 0.3168 L/kg 1compartment NA NA Rat Human +DTXSID4024729 TK.Half.Life 10 0.4224 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID4024729 Css NA 0.003688 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4024729 Css NA 0.02024 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4024729 Css NA 0.003508 mg/L PBTK NA 50% Rat Rat +DTXSID4024729 Css NA 0.01922 mg/L PBTK NA 95% Rat Rat +DTXSID4024771 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024771 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024771 Vd NA 0.4466 L/kg 1compartment NA NA Human Human +DTXSID4024771 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4024771 TK.Half.Life NA 0.8678 hours 1compartment NA NA Human Human +DTXSID4024771 Css NA 0.1648 mg/L 3compartmentss NA 50% Human Human +DTXSID4024771 Css NA 1.278 mg/L 3compartmentss NA 95% Human Human +DTXSID4024771 Css NA 0.1096 mg/L PBTK NA 50% Human Human +DTXSID4024771 Css NA 0.8082 mg/L PBTK NA 95% Human Human +DTXSID4024771 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024771 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024771 Vd NA 0.4433 L/kg 1compartment NA NA Rat Human DTXSID4024771 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024771 TK.Half.Life NA 8.029 hours 1compartment NA NA Rat Human -DTXSID4024771 Css NA 3.354 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024771 Css NA 13.23 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024771 Css NA 1.951 mg/L PBTK NA 50% Rat Human -DTXSID4024771 Css NA 7.289 mg/L PBTK NA 95% Rat Human -DTXSID4024800 Clint NA 14.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024800 Fup NA 0.2893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024800 Vd NA 1.949 L/kg 1compartment NA NA Human Human +DTXSID4024771 TK.Half.Life NA 0.494 hours 1compartment NA NA Rat Human +DTXSID4024771 Css NA 0.02139 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024771 Css NA 0.1339 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024771 Css NA 0.01391 mg/L PBTK NA 50% Rat Human +DTXSID4024771 Css NA 0.08198 mg/L PBTK NA 95% Rat Human +DTXSID4024800 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024800 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024800 Vd NA 1.587 L/kg 1compartment NA NA Human Human DTXSID4024800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024800 TK.Half.Life NA 3.796 hours 1compartment NA NA Human Human -DTXSID4024800 Css NA 0.1495 mg/L 3compartmentss NA 50% Human Human -DTXSID4024800 Css NA 0.9329 mg/L 3compartmentss NA 95% Human Human -DTXSID4024800 Css NA 0.1132 mg/L PBTK NA 50% Human Human -DTXSID4024800 Css NA 0.6614 mg/L PBTK NA 95% Human Human -DTXSID4024800 Clint NA 14.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024800 Fup NA 0.2893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024800 Vd NA 1.528 L/kg 1compartment NA NA Rat Human +DTXSID4024800 TK.Half.Life NA 3.111 hours 1compartment NA NA Human Human +DTXSID4024800 Css NA 0.1232 mg/L 3compartmentss NA 50% Human Human +DTXSID4024800 Css NA 0.8904 mg/L 3compartmentss NA 95% Human Human +DTXSID4024800 Css NA 0.08708 mg/L PBTK NA 50% Human Human +DTXSID4024800 Css NA 0.6042 mg/L PBTK NA 95% Human Human +DTXSID4024800 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024800 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024800 Vd NA 1.238 L/kg 1compartment NA NA Rat Human DTXSID4024800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024800 TK.Half.Life NA 1.339 hours 1compartment NA NA Rat Human -DTXSID4024800 Css NA 0.08026 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024800 Css NA 0.3817 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024800 Css NA 0.05842 mg/L PBTK NA 50% Rat Human -DTXSID4024800 Css NA 0.2613 mg/L PBTK NA 95% Rat Human -DTXSID4024931 Clint NA 25.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024931 Fup NA 0.2711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024931 Vd NA 3.693 L/kg 1compartment NA NA Human Human +DTXSID4024800 TK.Half.Life NA 1.188 hours 1compartment NA NA Rat Human +DTXSID4024800 Css NA 0.004409 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024800 Css NA 0.03418 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024800 Css NA 0.00303 mg/L PBTK NA 50% Rat Human +DTXSID4024800 Css NA 0.02212 mg/L PBTK NA 95% Rat Human +DTXSID4024931 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024931 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024931 Vd NA 3.031 L/kg 1compartment NA NA Human Human DTXSID4024931 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024931 TK.Half.Life NA 2.259 hours 1compartment NA NA Human Human -DTXSID4024931 Css NA 0.01562 mg/L 3compartmentss NA 50% Human Human -DTXSID4024931 Css NA 0.1469 mg/L 3compartmentss NA 95% Human Human -DTXSID4024931 Css NA 0.02255 mg/L PBTK NA 50% Human Human -DTXSID4024931 Css NA 0.1621 mg/L PBTK NA 95% Human Human -DTXSID4024931 Clint NA 25.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024931 Fup NA 0.2711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024931 Vd NA 3.651 L/kg 1compartment NA NA Rat Human +DTXSID4024931 TK.Half.Life NA 2.335 hours 1compartment NA NA Human Human +DTXSID4024931 Css NA 0.02428 mg/L 3compartmentss NA 50% Human Human +DTXSID4024931 Css NA 0.2298 mg/L 3compartmentss NA 95% Human Human +DTXSID4024931 Css NA 0.03077 mg/L PBTK NA 50% Human Human +DTXSID4024931 Css NA 0.2217 mg/L PBTK NA 95% Human Human +DTXSID4024931 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024931 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024931 Vd NA 2.994 L/kg 1compartment NA NA Rat Human DTXSID4024931 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024931 TK.Half.Life NA 1.184 hours 1compartment NA NA Rat Human -DTXSID4024931 Css NA 0.008104 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024931 Css NA 0.06139 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024931 Css NA 0.01181 mg/L PBTK NA 50% Rat Human -DTXSID4024931 Css NA 0.06684 mg/L PBTK NA 95% Rat Human -DTXSID4024937 Clint NA 18.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024937 Fup NA 0.0563 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024937 Vd NA 3.013 L/kg 1compartment NA NA Human Human -DTXSID4024937 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID4024937 TK.Half.Life NA 48.4 hours 1compartment NA NA Human Human -DTXSID4024937 Css NA 1.938 mg/L 3compartmentss NA 50% Human Human -DTXSID4024937 Css NA 12.08 mg/L 3compartmentss NA 95% Human Human -DTXSID4024937 Css NA 1.349 mg/L PBTK NA 50% Human Human -DTXSID4024937 Css NA 8.189 mg/L PBTK NA 95% Human Human -DTXSID4024937 Clint NA 18.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024937 Fup NA 0.0563 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024937 Vd NA 2.259 L/kg 1compartment NA NA Rat Human +DTXSID4024931 TK.Half.Life NA 1.261 hours 1compartment NA NA Rat Human +DTXSID4024931 Css NA 0.002908 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024931 Css NA 0.02242 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024931 Css NA 0.003856 mg/L PBTK NA 50% Rat Human +DTXSID4024931 Css NA 0.0216 mg/L PBTK NA 95% Rat Human +DTXSID4024937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024937 Fup 0.0379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024937 Vd NA 2.964 L/kg 1compartment NA NA Human Human +DTXSID4024937 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4024937 TK.Half.Life NA 43.43 hours 1compartment NA NA Human Human +DTXSID4024937 Css NA 1.796 mg/L 3compartmentss NA 50% Human Human +DTXSID4024937 Css NA 12 mg/L 3compartmentss NA 95% Human Human +DTXSID4024937 Css NA 1.232 mg/L PBTK NA 50% Human Human +DTXSID4024937 Css NA 7.915 mg/L PBTK NA 95% Human Human +DTXSID4024937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024937 Fup 0.0379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024937 Vd NA 2.22 L/kg 1compartment NA NA Rat Human DTXSID4024937 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4024937 TK.Half.Life NA 7.695 hours 1compartment NA NA Rat Human -DTXSID4024937 Css NA 1.098 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024937 Css NA 5.636 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024937 Css NA 0.7254 mg/L PBTK NA 50% Rat Human -DTXSID4024937 Css NA 3.641 mg/L PBTK NA 95% Rat Human -DTXSID4024981 Clint NA 1.539 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024981 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024981 Vd NA 0.2677 L/kg 1compartment NA NA Human Human -DTXSID4024981 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4024981 TK.Half.Life NA 18.21 hours 1compartment NA NA Human Human -DTXSID4024981 Css NA 11.78 mg/L 3compartmentss NA 50% Human Human -DTXSID4024981 Css NA 87.2 mg/L 3compartmentss NA 95% Human Human -DTXSID4024981 Css NA 7.078 mg/L PBTK NA 50% Human Human -DTXSID4024981 Css NA 50.69 mg/L PBTK NA 95% Human Human -DTXSID4024981 Clint NA 1.539 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024981 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024981 Vd NA 0.2607 L/kg 1compartment NA NA Rat Human +DTXSID4024937 TK.Half.Life NA 7.324 hours 1compartment NA NA Rat Human +DTXSID4024937 Css NA 0.231 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024937 Css NA 1.303 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024937 Css NA 0.1568 mg/L PBTK NA 50% Rat Human +DTXSID4024937 Css NA 0.8709 mg/L PBTK NA 95% Rat Human +DTXSID4024981 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024981 Fup 0.059 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024981 Vd NA 0.3665 L/kg 1compartment NA NA Human Human +DTXSID4024981 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID4024981 TK.Half.Life NA 40.21 hours 1compartment NA NA Human Human +DTXSID4024981 Css NA 16.95 mg/L 3compartmentss NA 50% Human Human +DTXSID4024981 Css NA 79.77 mg/L 3compartmentss NA 95% Human Human +DTXSID4024981 Css NA 10.62 mg/L PBTK NA 50% Human Human +DTXSID4024981 Css NA 47.53 mg/L PBTK NA 95% Human Human +DTXSID4024981 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024981 Fup 0.059 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024981 Vd NA 0.3582 L/kg 1compartment NA NA Rat Human DTXSID4024981 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4024981 TK.Half.Life NA 9.546 hours 1compartment NA NA Rat Human -DTXSID4024981 Css NA 5.362 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024981 Css NA 31.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024981 Css NA 3.016 mg/L PBTK NA 50% Rat Human -DTXSID4024981 Css NA 17.08 mg/L PBTK NA 95% Rat Human -DTXSID4024983 Clint NA 0.8016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024983 Fup NA 0.689 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4024983 Vd NA 1.456 L/kg 1compartment NA NA Human Human -DTXSID4024983 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4024983 TK.Half.Life NA 6.918 hours 1compartment NA NA Human Human -DTXSID4024983 Css NA 0.4692 mg/L 3compartmentss NA 50% Human Human -DTXSID4024983 Css NA 3.208 mg/L 3compartmentss NA 95% Human Human -DTXSID4024983 Css NA 0.4216 mg/L PBTK NA 50% Human Human -DTXSID4024983 Css NA 2.133 mg/L PBTK NA 95% Human Human -DTXSID4024983 Clint NA 0.8016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024983 Fup NA 0.689 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4024983 Vd NA 1.282 L/kg 1compartment NA NA Rat Human -DTXSID4024983 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4024983 TK.Half.Life NA 2.601 hours 1compartment NA NA Rat Human -DTXSID4024983 Css NA 0.173 mg/L 3compartmentss NA 50% Rat Human -DTXSID4024983 Css NA 1.157 mg/L 3compartmentss NA 95% Rat Human -DTXSID4024983 Css NA 0.1516 mg/L PBTK NA 50% Rat Human -DTXSID4024983 Css NA 0.7084 mg/L PBTK NA 95% Rat Human -DTXSID4025082 Clint NA 306 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025082 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025082 Vd NA 2580 L/kg 1compartment NA NA Human Human -DTXSID4025082 Days.Css NA 1471 Days PBTK NA NA Human Human -DTXSID4025082 TK.Half.Life NA 5514 hours 1compartment NA NA Human Human -DTXSID4025082 Css NA 0.0004004 mg/L 3compartmentss NA 50% Human Human -DTXSID4025082 Css NA 0.0025 mg/L 3compartmentss NA 95% Human Human -DTXSID4025082 Css NA 0.1774 mg/L PBTK NA 50% Human Human -DTXSID4025082 Css NA 0.9894 mg/L PBTK NA 95% Human Human -DTXSID4025082 Clint NA 306 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025082 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025082 Vd NA 2395 L/kg 1compartment NA NA Rat Human -DTXSID4025082 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID4025082 TK.Half.Life NA 947.1 hours 1compartment NA NA Rat Human -DTXSID4025082 Css NA 0.0002044 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025082 Css NA 0.0009001 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025082 Css NA 0.09651 mg/L PBTK NA 50% Rat Human -DTXSID4025082 Css NA 0.4243 mg/L PBTK NA 95% Rat Human +DTXSID4024981 TK.Half.Life NA 13.38 hours 1compartment NA NA Rat Human +DTXSID4024981 Css NA 1.101 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024981 Css NA 4.398 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024981 Css NA 0.6708 mg/L PBTK NA 50% Rat Human +DTXSID4024981 Css NA 2.519 mg/L PBTK NA 95% Rat Human +DTXSID4024985 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024985 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4024985 Vd NA 0.9106 L/kg 1compartment NA NA Human Human +DTXSID4024985 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4024985 TK.Half.Life NA 13.28 hours 1compartment NA NA Human Human +DTXSID4024985 Css NA 1.481 mg/L 3compartmentss NA 50% Human Human +DTXSID4024985 Css NA 7.176 mg/L 3compartmentss NA 95% Human Human +DTXSID4024985 Css NA 1.185 mg/L PBTK NA 50% Human Human +DTXSID4024985 Css NA 4.627 mg/L PBTK NA 95% Human Human +DTXSID4024985 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024985 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4024985 Vd NA 0.839 L/kg 1compartment NA NA Rat Human +DTXSID4024985 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4024985 TK.Half.Life NA 4.044 hours 1compartment NA NA Rat Human +DTXSID4024985 Css NA 0.09428 mg/L 3compartmentss NA 50% Rat Human +DTXSID4024985 Css NA 0.3993 mg/L 3compartmentss NA 95% Rat Human +DTXSID4024985 Css NA 0.07459 mg/L PBTK NA 50% Rat Human +DTXSID4024985 Css NA 0.2511 mg/L PBTK NA 95% Rat Human DTXSID4025113 Clint NA 23.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4025113 Fup NA 0.6929 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025113 Vd NA 2.621 L/kg 1compartment NA NA Human Human +DTXSID4025113 Vd NA 2.297 L/kg 1compartment NA NA Human Human DTXSID4025113 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025113 TK.Half.Life NA 1.652 hours 1compartment NA NA Human Human -DTXSID4025113 Css NA 0.02065 mg/L 3compartmentss NA 50% Human Human -DTXSID4025113 Css NA 0.2479 mg/L 3compartmentss NA 95% Human Human -DTXSID4025113 Css NA 0.02357 mg/L PBTK NA 50% Human Human -DTXSID4025113 Css NA 0.2052 mg/L PBTK NA 95% Human Human +DTXSID4025113 TK.Half.Life NA 1.515 hours 1compartment NA NA Human Human +DTXSID4025113 Css NA 0.01565 mg/L 3compartmentss NA 50% Human Human +DTXSID4025113 Css NA 0.2208 mg/L 3compartmentss NA 95% Human Human +DTXSID4025113 Css NA 0.01687 mg/L PBTK NA 50% Human Human +DTXSID4025113 Css NA 0.1769 mg/L PBTK NA 95% Human Human DTXSID4025113 Clint NA 23.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4025113 Fup NA 0.6929 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025113 Vd NA 2.608 L/kg 1compartment NA NA Rat Human +DTXSID4025113 Vd NA 2.283 L/kg 1compartment NA NA Rat Human DTXSID4025113 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025113 TK.Half.Life NA 0.838 hours 1compartment NA NA Rat Human -DTXSID4025113 Css NA 0.01023 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025113 Css NA 0.1117 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025113 Css NA 0.01193 mg/L PBTK NA 50% Rat Human -DTXSID4025113 Css NA 0.08667 mg/L PBTK NA 95% Rat Human -DTXSID4025165 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025165 Fup NA 0.1226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025165 Vd NA 1.455 L/kg 1compartment NA NA Human Human -DTXSID4025165 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID4025165 TK.Half.Life NA 102.9 hours 1compartment NA NA Human Human -DTXSID4025165 Css NA 9.695 mg/L 3compartmentss NA 50% Human Human -DTXSID4025165 Css NA 41.11 mg/L 3compartmentss NA 95% Human Human -DTXSID4025165 Css NA 6.54 mg/L PBTK NA 50% Human Human -DTXSID4025165 Css NA 25 mg/L PBTK NA 95% Human Human -DTXSID4025165 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025165 Fup NA 0.1226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025165 Vd NA 1.125 L/kg 1compartment NA NA Rat Human -DTXSID4025165 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID4025165 TK.Half.Life NA 21.87 hours 1compartment NA NA Rat Human -DTXSID4025165 Css NA 2.694 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025165 Css NA 9.53 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025165 Css NA 1.715 mg/L PBTK NA 50% Rat Human -DTXSID4025165 Css NA 5.436 mg/L PBTK NA 95% Rat Human -DTXSID4025167 Clint NA 3.943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025167 Fup NA 0.084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025167 Vd NA 0.4345 L/kg 1compartment NA NA Human Human +DTXSID4025113 TK.Half.Life NA 0.763 hours 1compartment NA NA Rat Human +DTXSID4025113 Css NA 0.0005494 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025113 Css NA 0.0086 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025113 Css NA 0.0006018 mg/L PBTK NA 50% Rat Human +DTXSID4025113 Css NA 0.006838 mg/L PBTK NA 95% Rat Human +DTXSID4025165 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025165 Fup 0.0985 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025165 Vd NA 1.312 L/kg 1compartment NA NA Human Human +DTXSID4025165 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4025165 TK.Half.Life NA 9.405 hours 1compartment NA NA Human Human +DTXSID4025165 Css NA 0.9826 mg/L 3compartmentss NA 50% Human Human +DTXSID4025165 Css NA 6.67 mg/L 3compartmentss NA 95% Human Human +DTXSID4025165 Css NA 0.6442 mg/L PBTK NA 50% Human Human +DTXSID4025165 Css NA 4.099 mg/L PBTK NA 95% Human Human +DTXSID4025165 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025165 Fup 0.0985 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025165 Vd NA 1.011 L/kg 1compartment NA NA Rat Human +DTXSID4025165 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4025165 TK.Half.Life NA 3.811 hours 1compartment NA NA Rat Human +DTXSID4025165 Css NA 0.1196 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025165 Css NA 0.5955 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025165 Css NA 0.07667 mg/L PBTK NA 50% Rat Human +DTXSID4025165 Css NA 0.3544 mg/L PBTK NA 95% Rat Human +DTXSID4025167 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025167 Fup 0.0541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025167 Vd NA 0.322 L/kg 1compartment NA NA Human Human DTXSID4025167 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025167 TK.Half.Life NA 4.725 hours 1compartment NA NA Human Human -DTXSID4025167 Css NA 1.664 mg/L 3compartmentss NA 50% Human Human -DTXSID4025167 Css NA 10.88 mg/L 3compartmentss NA 95% Human Human -DTXSID4025167 Css NA 1.084 mg/L PBTK NA 50% Human Human -DTXSID4025167 Css NA 6.446 mg/L PBTK NA 95% Human Human -DTXSID4025167 Clint NA 3.943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025167 Fup NA 0.084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025167 Vd NA 0.4265 L/kg 1compartment NA NA Rat Human +DTXSID4025167 TK.Half.Life NA 3.64 hours 1compartment NA NA Human Human +DTXSID4025167 Css NA 0.9798 mg/L 3compartmentss NA 50% Human Human +DTXSID4025167 Css NA 7.186 mg/L 3compartmentss NA 95% Human Human +DTXSID4025167 Css NA 0.6066 mg/L PBTK NA 50% Human Human +DTXSID4025167 Css NA 4.258 mg/L PBTK NA 95% Human Human +DTXSID4025167 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025167 Fup 0.0541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025167 Vd NA 0.3159 L/kg 1compartment NA NA Rat Human DTXSID4025167 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025167 TK.Half.Life NA 2.778 hours 1compartment NA NA Rat Human -DTXSID4025167 Css NA 0.8473 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025167 Css NA 4.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025167 Css NA 0.5155 mg/L PBTK NA 50% Rat Human -DTXSID4025167 Css NA 2.283 mg/L PBTK NA 95% Rat Human -DTXSID4025292 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025292 Fup NA 0.626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025292 Vd NA 1.38 L/kg 1compartment NA NA Human Human -DTXSID4025292 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4025292 TK.Half.Life NA 16.23 hours 1compartment NA NA Human Human -DTXSID4025292 Css NA 1.198 mg/L 3compartmentss NA 50% Human Human -DTXSID4025292 Css NA 8.094 mg/L 3compartmentss NA 95% Human Human -DTXSID4025292 Css NA 1.044 mg/L PBTK NA 50% Human Human -DTXSID4025292 Css NA 5.289 mg/L PBTK NA 95% Human Human -DTXSID4025292 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025292 Fup NA 0.626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025292 Vd NA 1.214 L/kg 1compartment NA NA Rat Human +DTXSID4025167 TK.Half.Life NA 2.227 hours 1compartment NA NA Rat Human +DTXSID4025167 Css NA 0.0103 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025167 Css NA 0.06424 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025167 Css NA 0.005956 mg/L PBTK NA 50% Rat Human +DTXSID4025167 Css NA 0.03598 mg/L PBTK NA 95% Rat Human +DTXSID4025292 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025292 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025292 Vd NA 2.945 L/kg 1compartment NA NA Human Human +DTXSID4025292 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4025292 TK.Half.Life NA 9.001 hours 1compartment NA NA Human Human +DTXSID4025292 Css NA 0.2682 mg/L 3compartmentss NA 50% Human Human +DTXSID4025292 Css NA 1.688 mg/L 3compartmentss NA 95% Human Human +DTXSID4025292 Css NA 0.1972 mg/L PBTK NA 50% Human Human +DTXSID4025292 Css NA 1.204 mg/L PBTK NA 95% Human Human +DTXSID4025292 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025292 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025292 Vd NA 2.24 L/kg 1compartment NA NA Rat Human DTXSID4025292 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025292 TK.Half.Life NA 4.418 hours 1compartment NA NA Rat Human -DTXSID4025292 Css NA 0.3138 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025292 Css NA 2.028 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025292 Css NA 0.2665 mg/L PBTK NA 50% Rat Human -DTXSID4025292 Css NA 1.231 mg/L PBTK NA 95% Rat Human -DTXSID4025404 Clint NA 28.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025404 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025404 Vd NA 2.515 L/kg 1compartment NA NA Human Human -DTXSID4025404 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4025404 TK.Half.Life NA 23.48 hours 1compartment NA NA Human Human -DTXSID4025404 Css NA 1.298 mg/L 3compartmentss NA 50% Human Human -DTXSID4025404 Css NA 9.171 mg/L 3compartmentss NA 95% Human Human -DTXSID4025404 Css NA 0.858 mg/L PBTK NA 50% Human Human -DTXSID4025404 Css NA 5.793 mg/L PBTK NA 95% Human Human -DTXSID4025404 Clint NA 28.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025404 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025404 Vd NA 1.877 L/kg 1compartment NA NA Rat Human -DTXSID4025404 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4025404 TK.Half.Life NA 5.81 hours 1compartment NA NA Rat Human -DTXSID4025404 Css NA 0.7183 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025404 Css NA 4.366 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025404 Css NA 0.4531 mg/L PBTK NA 50% Rat Human -DTXSID4025404 Css NA 2.646 mg/L PBTK NA 95% Rat Human -DTXSID4025454 Clint NA 67.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025454 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025454 Vd NA 2.452 L/kg 1compartment NA NA Human Human -DTXSID4025454 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025454 TK.Half.Life NA 7.905 hours 1compartment NA NA Human Human -DTXSID4025454 Css NA 0.3671 mg/L 3compartmentss NA 50% Human Human -DTXSID4025454 Css NA 2.609 mg/L 3compartmentss NA 95% Human Human -DTXSID4025454 Css NA 0.2448 mg/L PBTK NA 50% Human Human -DTXSID4025454 Css NA 1.674 mg/L PBTK NA 95% Human Human -DTXSID4025454 Clint NA 67.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025454 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025454 Vd NA 1.835 L/kg 1compartment NA NA Rat Human -DTXSID4025454 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025454 TK.Half.Life NA 2.155 hours 1compartment NA NA Rat Human -DTXSID4025454 Css NA 0.2058 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025454 Css NA 1.264 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025454 Css NA 0.13 mg/L PBTK NA 50% Rat Human -DTXSID4025454 Css NA 0.7571 mg/L PBTK NA 95% Rat Human -DTXSID4025581 Clint NA 193.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025581 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025581 Vd NA 0.9071 L/kg 1compartment NA NA Human Human +DTXSID4025292 TK.Half.Life NA 1.907 hours 1compartment NA NA Rat Human +DTXSID4025292 Css NA 0.0335 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025292 Css NA 0.1677 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025292 Css NA 0.02478 mg/L PBTK NA 50% Rat Human +DTXSID4025292 Css NA 0.1174 mg/L PBTK NA 95% Rat Human +DTXSID4025404 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025404 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025404 Vd NA 3.596 L/kg 1compartment NA NA Human Human +DTXSID4025404 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID4025404 TK.Half.Life NA 108 hours 1compartment NA NA Human Human +DTXSID4025404 Css NA 3.284 mg/L 3compartmentss NA 50% Human Human +DTXSID4025404 Css NA 18.7 mg/L 3compartmentss NA 95% Human Human +DTXSID4025404 Css NA 2.37 mg/L PBTK NA 50% Human Human +DTXSID4025404 Css NA 13.49 mg/L PBTK NA 95% Human Human +DTXSID4025404 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025404 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025404 Vd NA 2.709 L/kg 1compartment NA NA Rat Human +DTXSID4025404 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID4025404 TK.Half.Life NA 14.32 hours 1compartment NA NA Rat Human +DTXSID4025404 Css NA 0.4275 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025404 Css NA 2.093 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025404 Css NA 0.3068 mg/L PBTK NA 50% Rat Human +DTXSID4025404 Css NA 1.549 mg/L PBTK NA 95% Rat Human +DTXSID4025454 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025454 Fup 0.0208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025454 Vd NA 2.537 L/kg 1compartment NA NA Human Human +DTXSID4025454 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4025454 TK.Half.Life NA 31.55 hours 1compartment NA NA Human Human +DTXSID4025454 Css NA 1.712 mg/L 3compartmentss NA 50% Human Human +DTXSID4025454 Css NA 12.96 mg/L 3compartmentss NA 95% Human Human +DTXSID4025454 Css NA 1.133 mg/L PBTK NA 50% Human Human +DTXSID4025454 Css NA 8.259 mg/L PBTK NA 95% Human Human +DTXSID4025454 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025454 Fup 0.0208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025454 Vd NA 1.894 L/kg 1compartment NA NA Rat Human +DTXSID4025454 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4025454 TK.Half.Life NA 7.61 hours 1compartment NA NA Rat Human +DTXSID4025454 Css NA 0.2195 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025454 Css NA 1.32 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025454 Css NA 0.1429 mg/L PBTK NA 50% Rat Human +DTXSID4025454 Css NA 0.8222 mg/L PBTK NA 95% Rat Human +DTXSID4025581 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025581 Fup 0.0315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025581 Vd NA 1.232 L/kg 1compartment NA NA Human Human DTXSID4025581 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025581 TK.Half.Life NA 1.875 hours 1compartment NA NA Human Human -DTXSID4025581 Css NA 0.2116 mg/L 3compartmentss NA 50% Human Human -DTXSID4025581 Css NA 2.16 mg/L 3compartmentss NA 95% Human Human -DTXSID4025581 Css NA 0.1286 mg/L PBTK NA 50% Human Human -DTXSID4025581 Css NA 1.267 mg/L PBTK NA 95% Human Human -DTXSID4025581 Clint NA 193.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025581 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025581 Vd NA 0.6765 L/kg 1compartment NA NA Rat Human +DTXSID4025581 TK.Half.Life NA 7.771 hours 1compartment NA NA Human Human +DTXSID4025581 Css NA 0.9221 mg/L 3compartmentss NA 50% Human Human +DTXSID4025581 Css NA 8.588 mg/L 3compartmentss NA 95% Human Human +DTXSID4025581 Css NA 0.5918 mg/L PBTK NA 50% Human Human +DTXSID4025581 Css NA 5.251 mg/L PBTK NA 95% Human Human +DTXSID4025581 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025581 Fup 0.0315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025581 Vd NA 0.932 L/kg 1compartment NA NA Rat Human DTXSID4025581 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025581 TK.Half.Life NA 0.7604 hours 1compartment NA NA Rat Human -DTXSID4025581 Css NA 0.1211 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025581 Css NA 1.042 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025581 Css NA 0.06889 mg/L PBTK NA 50% Rat Human -DTXSID4025581 Css NA 0.5792 mg/L PBTK NA 95% Rat Human -DTXSID4025587 Clint NA 17.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025587 Fup NA 0.3414 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025587 Vd NA 1.728 L/kg 1compartment NA NA Human Human +DTXSID4025581 TK.Half.Life NA 3.27 hours 1compartment NA NA Rat Human +DTXSID4025581 Css NA 0.1206 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025581 Css NA 0.8906 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025581 Css NA 0.07514 mg/L PBTK NA 50% Rat Human +DTXSID4025581 Css NA 0.5199 mg/L PBTK NA 95% Rat Human +DTXSID4025587 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025587 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025587 Vd NA 1.339 L/kg 1compartment NA NA Human Human DTXSID4025587 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025587 TK.Half.Life NA 2.526 hours 1compartment NA NA Human Human -DTXSID4025587 Css NA 0.09165 mg/L 3compartmentss NA 50% Human Human -DTXSID4025587 Css NA 0.6234 mg/L 3compartmentss NA 95% Human Human -DTXSID4025587 Css NA 0.0714 mg/L PBTK NA 50% Human Human -DTXSID4025587 Css NA 0.44 mg/L PBTK NA 95% Human Human -DTXSID4025587 Clint NA 17.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025587 Fup NA 0.3414 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025587 Vd NA 1.386 L/kg 1compartment NA NA Rat Human +DTXSID4025587 TK.Half.Life NA 3.129 hours 1compartment NA NA Human Human +DTXSID4025587 Css NA 0.2247 mg/L 3compartmentss NA 50% Human Human +DTXSID4025587 Css NA 1.846 mg/L 3compartmentss NA 95% Human Human +DTXSID4025587 Css NA 0.1507 mg/L PBTK NA 50% Human Human +DTXSID4025587 Css NA 1.143 mg/L PBTK NA 95% Human Human +DTXSID4025587 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025587 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025587 Vd NA 1.041 L/kg 1compartment NA NA Rat Human DTXSID4025587 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025587 TK.Half.Life NA 0.9598 hours 1compartment NA NA Rat Human -DTXSID4025587 Css NA 0.04884 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025587 Css NA 0.2587 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025587 Css NA 0.03656 mg/L PBTK NA 50% Rat Human -DTXSID4025587 Css NA 0.1715 mg/L PBTK NA 95% Rat Human -DTXSID4025610 Clint NA 106.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025610 Fup NA 0.4468 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025610 Vd NA 0.9031 L/kg 1compartment NA NA Human Human +DTXSID4025587 TK.Half.Life NA 1.265 hours 1compartment NA NA Rat Human +DTXSID4025587 Css NA 0.02878 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025587 Css NA 0.1812 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025587 Css NA 0.01901 mg/L PBTK NA 50% Rat Human +DTXSID4025587 Css NA 0.1116 mg/L PBTK NA 95% Rat Human +DTXSID4025610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025610 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025610 Vd NA 0.7283 L/kg 1compartment NA NA Human Human DTXSID4025610 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025610 TK.Half.Life NA 0.6822 hours 1compartment NA NA Human Human -DTXSID4025610 Css NA 0.009706 mg/L 3compartmentss NA 50% Human Human -DTXSID4025610 Css NA 0.08414 mg/L 3compartmentss NA 95% Human Human -DTXSID4025610 Css NA 0.007637 mg/L PBTK NA 50% Human Human -DTXSID4025610 Css NA 0.05866 mg/L PBTK NA 95% Human Human -DTXSID4025610 Clint NA 106.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025610 Fup NA 0.4468 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025610 Vd NA 0.8297 L/kg 1compartment NA NA Rat Human +DTXSID4025610 TK.Half.Life NA 0.9334 hours 1compartment NA NA Human Human +DTXSID4025610 Css NA 0.06479 mg/L 3compartmentss NA 50% Human Human +DTXSID4025610 Css NA 0.5091 mg/L 3compartmentss NA 95% Human Human +DTXSID4025610 Css NA 0.04721 mg/L PBTK NA 50% Human Human +DTXSID4025610 Css NA 0.3315 mg/L PBTK NA 95% Human Human +DTXSID4025610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025610 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025610 Vd NA 0.6683 L/kg 1compartment NA NA Rat Human DTXSID4025610 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025610 TK.Half.Life NA 0.2852 hours 1compartment NA NA Rat Human -DTXSID4025610 Css NA 0.005158 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025610 Css NA 0.03716 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025610 Css NA 0.003919 mg/L PBTK NA 50% Rat Human -DTXSID4025610 Css NA 0.02488 mg/L PBTK NA 95% Rat Human -DTXSID4025612 Clint NA 1.515 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025612 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025612 Vd NA 0.8835 L/kg 1compartment NA NA Human Human +DTXSID4025610 TK.Half.Life NA 0.4501 hours 1compartment NA NA Rat Human +DTXSID4025610 Css NA 0.008216 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025610 Css NA 0.04751 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025610 Css NA 0.005928 mg/L PBTK NA 50% Rat Human +DTXSID4025610 Css NA 0.03099 mg/L PBTK NA 95% Rat Human +DTXSID4025612 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025612 Fup 0.703 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025612 Vd NA 0.713 L/kg 1compartment NA NA Human Human DTXSID4025612 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025612 TK.Half.Life NA 1.885 hours 1compartment NA NA Human Human -DTXSID4025612 Css NA 0.2346 mg/L 3compartmentss NA 50% Human Human -DTXSID4025612 Css NA 1.707 mg/L 3compartmentss NA 95% Human Human -DTXSID4025612 Css NA 0.2013 mg/L PBTK NA 50% Human Human -DTXSID4025612 Css NA 1.171 mg/L PBTK NA 95% Human Human -DTXSID4025612 Clint NA 1.515 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025612 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025612 Vd NA 0.9062 L/kg 1compartment NA NA Rat Human +DTXSID4025612 TK.Half.Life NA 6.576 hours 1compartment NA NA Human Human +DTXSID4025612 Css NA 1.053 mg/L 3compartmentss NA 50% Human Human +DTXSID4025612 Css NA 6.973 mg/L 3compartmentss NA 95% Human Human +DTXSID4025612 Css NA 0.8566 mg/L PBTK NA 50% Human Human +DTXSID4025612 Css NA 4.443 mg/L PBTK NA 95% Human Human +DTXSID4025612 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025612 Fup 0.703 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025612 Vd NA 0.7304 L/kg 1compartment NA NA Rat Human DTXSID4025612 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025612 TK.Half.Life NA 0.9684 hours 1compartment NA NA Rat Human -DTXSID4025612 Css NA 0.09387 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025612 Css NA 0.6068 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025612 Css NA 0.07994 mg/L PBTK NA 50% Rat Human -DTXSID4025612 Css NA 0.3748 mg/L PBTK NA 95% Rat Human -DTXSID4025662 Clint NA 4.324 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025662 Fup NA 0.375 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025662 Vd NA 1.612 L/kg 1compartment NA NA Human Human +DTXSID4025612 TK.Half.Life NA 2.292 hours 1compartment NA NA Rat Human +DTXSID4025612 Css NA 0.06293 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025612 Css NA 0.4124 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025612 Css NA 0.0512 mg/L PBTK NA 50% Rat Human +DTXSID4025612 Css NA 0.2516 mg/L PBTK NA 95% Rat Human +DTXSID4025660 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025660 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025660 Vd NA 2.977 L/kg 1compartment NA NA Human Human +DTXSID4025660 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4025660 TK.Half.Life NA 40.87 hours 1compartment NA NA Human Human +DTXSID4025660 Css NA 1.007 mg/L 3compartmentss NA 50% Human Human +DTXSID4025660 Css NA 6.206 mg/L 3compartmentss NA 95% Human Human +DTXSID4025660 Css NA 1.133 mg/L PBTK NA 50% Human Human +DTXSID4025660 Css NA 4.621 mg/L PBTK NA 95% Human Human +DTXSID4025660 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025660 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025660 Vd NA 2.995 L/kg 1compartment NA NA Rat Human +DTXSID4025660 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4025660 TK.Half.Life NA 13.54 hours 1compartment NA NA Rat Human +DTXSID4025660 Css NA 0.06144 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025660 Css NA 0.3497 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025660 Css NA 0.07071 mg/L PBTK NA 50% Rat Human +DTXSID4025660 Css NA 0.2536 mg/L PBTK NA 95% Rat Human +DTXSID4025662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025662 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025662 Vd NA 1.051 L/kg 1compartment NA NA Human Human DTXSID4025662 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025662 TK.Half.Life NA 5.078 hours 1compartment NA NA Human Human -DTXSID4025662 Css NA 0.2914 mg/L 3compartmentss NA 50% Human Human -DTXSID4025662 Css NA 1.664 mg/L 3compartmentss NA 95% Human Human -DTXSID4025662 Css NA 0.2296 mg/L PBTK NA 50% Human Human -DTXSID4025662 Css NA 1.157 mg/L PBTK NA 95% Human Human -DTXSID4025662 Clint NA 4.324 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025662 Fup NA 0.375 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025662 Vd NA 1.314 L/kg 1compartment NA NA Rat Human +DTXSID4025662 TK.Half.Life NA 2.013 hours 1compartment NA NA Human Human +DTXSID4025662 Css NA 0.1502 mg/L 3compartmentss NA 50% Human Human +DTXSID4025662 Css NA 1.134 mg/L 3compartmentss NA 95% Human Human +DTXSID4025662 Css NA 0.1024 mg/L PBTK NA 50% Human Human +DTXSID4025662 Css NA 0.7395 mg/L PBTK NA 95% Human Human +DTXSID4025662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025662 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025662 Vd NA 0.8488 L/kg 1compartment NA NA Rat Human DTXSID4025662 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025662 TK.Half.Life NA 1.994 hours 1compartment NA NA Rat Human -DTXSID4025662 Css NA 0.142 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025662 Css NA 0.6065 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025662 Css NA 0.1086 mg/L PBTK NA 50% Rat Human -DTXSID4025662 Css NA 0.395 mg/L PBTK NA 95% Rat Human -DTXSID4025668 Clint NA 123.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025668 Fup NA 0.2769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025668 Vd NA 2.205 L/kg 1compartment NA NA Human Human +DTXSID4025662 TK.Half.Life NA 0.8724 hours 1compartment NA NA Rat Human +DTXSID4025662 Css NA 0.01928 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025662 Css NA 0.115 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025662 Css NA 0.01297 mg/L PBTK NA 50% Rat Human +DTXSID4025662 Css NA 0.0715 mg/L PBTK NA 95% Rat Human +DTXSID4025668 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025668 Fup 0.0959 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025668 Vd NA 1.448 L/kg 1compartment NA NA Human Human DTXSID4025668 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025668 TK.Half.Life NA 2.036 hours 1compartment NA NA Human Human -DTXSID4025668 Css NA 0.02295 mg/L 3compartmentss NA 50% Human Human -DTXSID4025668 Css NA 0.1575 mg/L 3compartmentss NA 95% Human Human -DTXSID4025668 Css NA 0.01716 mg/L PBTK NA 50% Human Human -DTXSID4025668 Css NA 0.1125 mg/L PBTK NA 95% Human Human -DTXSID4025668 Clint NA 123.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025668 Fup NA 0.2769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025668 Vd NA 1.709 L/kg 1compartment NA NA Rat Human +DTXSID4025668 TK.Half.Life NA 4.198 hours 1compartment NA NA Human Human +DTXSID4025668 Css NA 0.3188 mg/L 3compartmentss NA 50% Human Human +DTXSID4025668 Css NA 2.446 mg/L 3compartmentss NA 95% Human Human +DTXSID4025668 Css NA 0.2094 mg/L PBTK NA 50% Human Human +DTXSID4025668 Css NA 1.529 mg/L PBTK NA 95% Human Human +DTXSID4025668 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025668 Fup 0.0959 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025668 Vd NA 1.109 L/kg 1compartment NA NA Rat Human DTXSID4025668 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025668 TK.Half.Life NA 0.6762 hours 1compartment NA NA Rat Human -DTXSID4025668 Css NA 0.01268 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025668 Css NA 0.07081 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025668 Css NA 0.009152 mg/L PBTK NA 50% Rat Human -DTXSID4025668 Css NA 0.04955 mg/L PBTK NA 95% Rat Human -DTXSID4025741 Clint NA 2.878 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025741 Fup NA 0.3362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025741 Vd NA 0.5781 L/kg 1compartment NA NA Human Human +DTXSID4025668 TK.Half.Life NA 1.648 hours 1compartment NA NA Rat Human +DTXSID4025668 Css NA 0.0412 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025668 Css NA 0.2451 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025668 Css NA 0.02663 mg/L PBTK NA 50% Rat Human +DTXSID4025668 Css NA 0.149 mg/L PBTK NA 95% Rat Human +DTXSID4025741 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025741 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025741 Vd NA 0.4396 L/kg 1compartment NA NA Human Human DTXSID4025741 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025741 TK.Half.Life NA 2.246 hours 1compartment NA NA Human Human -DTXSID4025741 Css NA 0.3999 mg/L 3compartmentss NA 50% Human Human -DTXSID4025741 Css NA 2.153 mg/L 3compartmentss NA 95% Human Human -DTXSID4025741 Css NA 0.2897 mg/L PBTK NA 50% Human Human -DTXSID4025741 Css NA 1.379 mg/L PBTK NA 95% Human Human -DTXSID4025741 Clint NA 2.878 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025741 Fup NA 0.3362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025741 Vd NA 0.5354 L/kg 1compartment NA NA Rat Human +DTXSID4025741 TK.Half.Life NA 1.044 hours 1compartment NA NA Human Human +DTXSID4025741 Css NA 0.2458 mg/L 3compartmentss NA 50% Human Human +DTXSID4025741 Css NA 2.017 mg/L 3compartmentss NA 95% Human Human +DTXSID4025741 Css NA 0.1535 mg/L PBTK NA 50% Human Human +DTXSID4025741 Css NA 1.222 mg/L PBTK NA 95% Human Human +DTXSID4025741 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025741 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025741 Vd NA 0.3856 L/kg 1compartment NA NA Rat Human DTXSID4025741 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025741 TK.Half.Life NA 1.142 hours 1compartment NA NA Rat Human -DTXSID4025741 Css NA 0.1878 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025741 Css NA 0.7906 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025741 Css NA 0.1287 mg/L PBTK NA 50% Rat Human -DTXSID4025741 Css NA 0.4732 mg/L PBTK NA 95% Rat Human -DTXSID4025743 Clint NA 3.152 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025743 Fup NA 0.2325 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025743 Vd NA 2.119 L/kg 1compartment NA NA Human Human -DTXSID4025743 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4025743 TK.Half.Life NA 16.81 hours 1compartment NA NA Human Human -DTXSID4025743 Css NA 0.8692 mg/L 3compartmentss NA 50% Human Human -DTXSID4025743 Css NA 3.968 mg/L 3compartmentss NA 95% Human Human -DTXSID4025743 Css NA 0.643 mg/L PBTK NA 50% Human Human -DTXSID4025743 Css NA 2.739 mg/L PBTK NA 95% Human Human -DTXSID4025743 Clint NA 3.152 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025743 Fup NA 0.2325 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025743 Vd NA 1.637 L/kg 1compartment NA NA Rat Human +DTXSID4025741 TK.Half.Life NA 0.5332 hours 1compartment NA NA Rat Human +DTXSID4025741 Css NA 0.03177 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025741 Css NA 0.2 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025741 Css NA 0.01941 mg/L PBTK NA 50% Rat Human +DTXSID4025741 Css NA 0.1168 mg/L PBTK NA 95% Rat Human +DTXSID4025743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025743 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025743 Vd NA 1.675 L/kg 1compartment NA NA Human Human +DTXSID4025743 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4025743 TK.Half.Life NA 4.807 hours 1compartment NA NA Human Human +DTXSID4025743 Css NA 0.308 mg/L 3compartmentss NA 50% Human Human +DTXSID4025743 Css NA 2.222 mg/L 3compartmentss NA 95% Human Human +DTXSID4025743 Css NA 0.2066 mg/L PBTK NA 50% Human Human +DTXSID4025743 Css NA 1.412 mg/L PBTK NA 95% Human Human +DTXSID4025743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025743 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025743 Vd NA 1.278 L/kg 1compartment NA NA Rat Human DTXSID4025743 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025743 TK.Half.Life NA 5.008 hours 1compartment NA NA Rat Human -DTXSID4025743 Css NA 0.4208 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025743 Css NA 1.425 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025743 Css NA 0.2989 mg/L PBTK NA 50% Rat Human -DTXSID4025743 Css NA 0.9248 mg/L PBTK NA 95% Rat Human -DTXSID4025745 Clint NA 3.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025745 Fup NA 0.2188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025745 Vd NA 2.05 L/kg 1compartment NA NA Human Human -DTXSID4025745 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4025745 TK.Half.Life NA 14.39 hours 1compartment NA NA Human Human -DTXSID4025745 Css NA 0.7714 mg/L 3compartmentss NA 50% Human Human -DTXSID4025745 Css NA 3.671 mg/L 3compartmentss NA 95% Human Human -DTXSID4025745 Css NA 0.5623 mg/L PBTK NA 50% Human Human -DTXSID4025745 Css NA 2.507 mg/L PBTK NA 95% Human Human -DTXSID4025745 Clint NA 3.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025745 Fup NA 0.2188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025745 Vd NA 1.584 L/kg 1compartment NA NA Rat Human +DTXSID4025743 TK.Half.Life NA 1.777 hours 1compartment NA NA Rat Human +DTXSID4025743 Css NA 0.03921 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025743 Css NA 0.2344 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025743 Css NA 0.02567 mg/L PBTK NA 50% Rat Human +DTXSID4025743 Css NA 0.1452 mg/L PBTK NA 95% Rat Human +DTXSID4025745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025745 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025745 Vd NA 1.621 L/kg 1compartment NA NA Human Human +DTXSID4025745 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4025745 TK.Half.Life NA 4.158 hours 1compartment NA NA Human Human +DTXSID4025745 Css NA 0.2565 mg/L 3compartmentss NA 50% Human Human +DTXSID4025745 Css NA 1.867 mg/L 3compartmentss NA 95% Human Human +DTXSID4025745 Css NA 0.1737 mg/L PBTK NA 50% Human Human +DTXSID4025745 Css NA 1.215 mg/L PBTK NA 95% Human Human +DTXSID4025745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025745 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025745 Vd NA 1.244 L/kg 1compartment NA NA Rat Human DTXSID4025745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025745 TK.Half.Life NA 4.495 hours 1compartment NA NA Rat Human -DTXSID4025745 Css NA 0.3762 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025745 Css NA 1.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025745 Css NA 0.2651 mg/L PBTK NA 50% Rat Human -DTXSID4025745 Css NA 0.8522 mg/L PBTK NA 95% Rat Human -DTXSID4025749 Clint NA 8.039 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025749 Fup NA 0.0557 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025749 Vd NA 2.411 L/kg 1compartment NA NA Human Human -DTXSID4025749 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4025749 TK.Half.Life NA 36.1 hours 1compartment NA NA Human Human -DTXSID4025749 Css NA 2.077 mg/L 3compartmentss NA 50% Human Human -DTXSID4025749 Css NA 12.75 mg/L 3compartmentss NA 95% Human Human -DTXSID4025749 Css NA 1.394 mg/L PBTK NA 50% Human Human -DTXSID4025749 Css NA 8.234 mg/L PBTK NA 95% Human Human -DTXSID4025749 Clint NA 8.039 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025749 Fup NA 0.0557 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025749 Vd NA 1.808 L/kg 1compartment NA NA Rat Human -DTXSID4025749 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4025749 TK.Half.Life NA 9.263 hours 1compartment NA NA Rat Human -DTXSID4025749 Css NA 1.131 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025749 Css NA 5.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025749 Css NA 0.721 mg/L PBTK NA 50% Rat Human -DTXSID4025749 Css NA 3.161 mg/L PBTK NA 95% Rat Human -DTXSID4025791 Clint NA 5.161 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025791 Fup NA 0.4417 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025791 Vd NA 2.037 L/kg 1compartment NA NA Human Human +DTXSID4025745 TK.Half.Life NA 1.563 hours 1compartment NA NA Rat Human +DTXSID4025745 Css NA 0.0332 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025745 Css NA 0.1934 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025745 Css NA 0.02205 mg/L PBTK NA 50% Rat Human +DTXSID4025745 Css NA 0.1204 mg/L PBTK NA 95% Rat Human +DTXSID4025749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025749 Fup 0.0369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025749 Vd NA 2.169 L/kg 1compartment NA NA Human Human +DTXSID4025749 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4025749 TK.Half.Life NA 15.61 hours 1compartment NA NA Human Human +DTXSID4025749 Css NA 0.987 mg/L 3compartmentss NA 50% Human Human +DTXSID4025749 Css NA 7.551 mg/L 3compartmentss NA 95% Human Human +DTXSID4025749 Css NA 0.6459 mg/L PBTK NA 50% Human Human +DTXSID4025749 Css NA 4.718 mg/L PBTK NA 95% Human Human +DTXSID4025749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025749 Fup 0.0369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025749 Vd NA 1.621 L/kg 1compartment NA NA Rat Human +DTXSID4025749 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4025749 TK.Half.Life NA 4.699 hours 1compartment NA NA Rat Human +DTXSID4025749 Css NA 0.1283 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025749 Css NA 0.7562 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025749 Css NA 0.08206 mg/L PBTK NA 50% Rat Human +DTXSID4025749 Css NA 0.4589 mg/L PBTK NA 95% Rat Human +DTXSID4025791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025791 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025791 Vd NA 1.232 L/kg 1compartment NA NA Human Human DTXSID4025791 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025791 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human -DTXSID4025791 Css NA 0.2532 mg/L 3compartmentss NA 50% Human Human -DTXSID4025791 Css NA 1.458 mg/L 3compartmentss NA 95% Human Human -DTXSID4025791 Css NA 0.2046 mg/L PBTK NA 50% Human Human -DTXSID4025791 Css NA 1.063 mg/L PBTK NA 95% Human Human -DTXSID4025791 Clint NA 5.161 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025791 Fup NA 0.4417 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025791 Vd NA 1.629 L/kg 1compartment NA NA Rat Human +DTXSID4025791 TK.Half.Life NA 2.566 hours 1compartment NA NA Human Human +DTXSID4025791 Css NA 0.1826 mg/L 3compartmentss NA 50% Human Human +DTXSID4025791 Css NA 1.42 mg/L 3compartmentss NA 95% Human Human +DTXSID4025791 Css NA 0.1231 mg/L PBTK NA 50% Human Human +DTXSID4025791 Css NA 0.8939 mg/L PBTK NA 95% Human Human +DTXSID4025791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025791 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025791 Vd NA 0.9722 L/kg 1compartment NA NA Rat Human DTXSID4025791 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025791 TK.Half.Life NA 1.992 hours 1compartment NA NA Rat Human -DTXSID4025791 Css NA 0.126 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025791 Css NA 0.5406 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025791 Css NA 0.09924 mg/L PBTK NA 50% Rat Human -DTXSID4025791 Css NA 0.3686 mg/L PBTK NA 95% Rat Human -DTXSID4025824 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025824 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025824 Vd NA 2.497 L/kg 1compartment NA NA Human Human -DTXSID4025824 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4025824 TK.Half.Life NA 31.69 hours 1compartment NA NA Human Human -DTXSID4025824 Css NA 1.081 mg/L 3compartmentss NA 50% Human Human -DTXSID4025824 Css NA 6.741 mg/L 3compartmentss NA 95% Human Human -DTXSID4025824 Css NA 1.06 mg/L PBTK NA 50% Human Human -DTXSID4025824 Css NA 4.764 mg/L PBTK NA 95% Human Human -DTXSID4025824 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025824 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025824 Vd NA 2.048 L/kg 1compartment NA NA Rat Human -DTXSID4025824 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025824 TK.Half.Life NA 5.55 hours 1compartment NA NA Rat Human -DTXSID4025824 Css NA 0.2851 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025824 Css NA 1.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025824 Css NA 0.2734 mg/L PBTK NA 50% Rat Human -DTXSID4025824 Css NA 0.9847 mg/L PBTK NA 95% Rat Human -DTXSID4025903 Clint NA 0.2958 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025903 Fup NA 0.5625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4025903 Vd NA 0.5249 L/kg 1compartment NA NA Human Human +DTXSID4025791 TK.Half.Life NA 1.065 hours 1compartment NA NA Rat Human +DTXSID4025791 Css NA 0.02358 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025791 Css NA 0.1421 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025791 Css NA 0.01574 mg/L PBTK NA 50% Rat Human +DTXSID4025791 Css NA 0.08805 mg/L PBTK NA 95% Rat Human +DTXSID4025903 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025903 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4025903 Vd NA 0.3478 L/kg 1compartment NA NA Human Human DTXSID4025903 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4025903 TK.Half.Life NA 4.109 hours 1compartment NA NA Human Human -DTXSID4025903 Css NA 0.9042 mg/L 3compartmentss NA 50% Human Human -DTXSID4025903 Css NA 6.068 mg/L 3compartmentss NA 95% Human Human -DTXSID4025903 Css NA 0.6729 mg/L PBTK NA 50% Human Human -DTXSID4025903 Css NA 3.76 mg/L PBTK NA 95% Human Human -DTXSID4025903 Clint NA 0.2958 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025903 Fup NA 0.5625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4025903 Vd NA 0.5234 L/kg 1compartment NA NA Rat Human +DTXSID4025903 TK.Half.Life NA 1.056 hours 1compartment NA NA Human Human +DTXSID4025903 Css NA 0.3033 mg/L 3compartmentss NA 50% Human Human +DTXSID4025903 Css NA 1.728 mg/L 3compartmentss NA 95% Human Human +DTXSID4025903 Css NA 0.1981 mg/L PBTK NA 50% Human Human +DTXSID4025903 Css NA 1.07 mg/L PBTK NA 95% Human Human +DTXSID4025903 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025903 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4025903 Vd NA 0.3449 L/kg 1compartment NA NA Rat Human DTXSID4025903 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4025903 TK.Half.Life NA 1.665 hours 1compartment NA NA Rat Human -DTXSID4025903 Css NA 0.2958 mg/L 3compartmentss NA 50% Rat Human -DTXSID4025903 Css NA 1.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID4025903 Css NA 0.2102 mg/L PBTK NA 50% Rat Human -DTXSID4025903 Css NA 1.051 mg/L PBTK NA 95% Rat Human -DTXSID4026000 Clint NA 4.015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026000 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026000 Vd NA 0.2334 L/kg 1compartment NA NA Human Human -DTXSID4026000 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026000 TK.Half.Life NA 8.721 hours 1compartment NA NA Human Human -DTXSID4026000 Css NA 6.698 mg/L 3compartmentss NA 50% Human Human -DTXSID4026000 Css NA 55.33 mg/L 3compartmentss NA 95% Human Human -DTXSID4026000 Css NA 4.013 mg/L PBTK NA 50% Human Human -DTXSID4026000 Css NA 32.06 mg/L PBTK NA 95% Human Human -DTXSID4026000 Clint NA 4.015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026000 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026000 Vd NA 0.2284 L/kg 1compartment NA NA Rat Human -DTXSID4026000 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026000 TK.Half.Life NA 5.216 hours 1compartment NA NA Rat Human -DTXSID4026000 Css NA 3.442 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026000 Css NA 22.14 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026000 Css NA 1.911 mg/L PBTK NA 50% Rat Human -DTXSID4026000 Css NA 12.04 mg/L PBTK NA 95% Rat Human -DTXSID4026054 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026054 Fup NA 0.9936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026054 Vd NA 0.8455 L/kg 1compartment NA NA Human Human -DTXSID4026054 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026054 TK.Half.Life NA 5.519 hours 1compartment NA NA Human Human -DTXSID4026054 Css NA 0.8446 mg/L 3compartmentss NA 50% Human Human -DTXSID4026054 Css NA 5.247 mg/L 3compartmentss NA 95% Human Human -DTXSID4026054 Css NA 0.7208 mg/L PBTK NA 50% Human Human -DTXSID4026054 Css NA 3.433 mg/L PBTK NA 95% Human Human -DTXSID4026054 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026054 Fup NA 0.9936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026054 Vd NA 0.8733 L/kg 1compartment NA NA Rat Human -DTXSID4026054 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026054 TK.Half.Life NA 1.939 hours 1compartment NA NA Rat Human -DTXSID4026054 Css NA 0.2144 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026054 Css NA 1.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026054 Css NA 0.1787 mg/L PBTK NA 50% Rat Human -DTXSID4026054 Css NA 0.7604 mg/L PBTK NA 95% Rat Human -DTXSID4026137 Clint NA 46.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026137 Fup NA 0.0052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026137 Vd NA 0.5728 L/kg 1compartment NA NA Human Human +DTXSID4025903 TK.Half.Life NA 0.6043 hours 1compartment NA NA Rat Human +DTXSID4025903 Css NA 0.03535 mg/L 3compartmentss NA 50% Rat Human +DTXSID4025903 Css NA 0.1552 mg/L 3compartmentss NA 95% Rat Human +DTXSID4025903 Css NA 0.02272 mg/L PBTK NA 50% Rat Human +DTXSID4025903 Css NA 0.09343 mg/L PBTK NA 95% Rat Human +DTXSID4026000 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026000 Fup 0.0314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026000 Vd NA 0.2857 L/kg 1compartment NA NA Human Human +DTXSID4026000 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID4026000 TK.Half.Life NA 58.89 hours 1compartment NA NA Human Human +DTXSID4026000 Css NA 33.83 mg/L 3compartmentss NA 50% Human Human +DTXSID4026000 Css NA 203.3 mg/L 3compartmentss NA 95% Human Human +DTXSID4026000 Css NA 20.44 mg/L PBTK NA 50% Human Human +DTXSID4026000 Css NA 117.3 mg/L PBTK NA 95% Human Human +DTXSID4026000 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026000 Fup 0.0314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026000 Vd NA 0.278 L/kg 1compartment NA NA Rat Human +DTXSID4026000 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4026000 TK.Half.Life NA 19.52 hours 1compartment NA NA Rat Human +DTXSID4026000 Css NA 2.233 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026000 Css NA 11.45 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026000 Css NA 1.308 mg/L PBTK NA 50% Rat Human +DTXSID4026000 Css NA 6.464 mg/L PBTK NA 95% Rat Human +DTXSID4026137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026137 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026137 Vd NA 0.7901 L/kg 1compartment NA NA Human Human DTXSID4026137 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026137 TK.Half.Life NA 7.782 hours 1compartment NA NA Human Human -DTXSID4026137 Css NA 2.454 mg/L 3compartmentss NA 50% Human Human -DTXSID4026137 Css NA 23.78 mg/L 3compartmentss NA 95% Human Human -DTXSID4026137 Css NA 1.442 mg/L PBTK NA 50% Human Human -DTXSID4026137 Css NA 13.88 mg/L PBTK NA 95% Human Human -DTXSID4026137 Clint NA 46.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026137 Fup NA 0.0052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026137 Vd NA 0.4275 L/kg 1compartment NA NA Rat Human +DTXSID4026137 TK.Half.Life NA 8.718 hours 1compartment NA NA Human Human +DTXSID4026137 Css NA 1.818 mg/L 3compartmentss NA 50% Human Human +DTXSID4026137 Css NA 17.92 mg/L 3compartmentss NA 95% Human Human +DTXSID4026137 Css NA 1.1 mg/L PBTK NA 50% Human Human +DTXSID4026137 Css NA 10.54 mg/L PBTK NA 95% Human Human +DTXSID4026137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026137 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026137 Vd NA 0.5888 L/kg 1compartment NA NA Rat Human DTXSID4026137 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026137 TK.Half.Life NA 3.769 hours 1compartment NA NA Rat Human -DTXSID4026137 Css NA 1.406 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026137 Css NA 11.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026137 Css NA 0.7748 mg/L PBTK NA 50% Rat Human -DTXSID4026137 Css NA 6.217 mg/L PBTK NA 95% Rat Human -DTXSID4026139 Clint NA 27.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026139 Fup NA 0.0984 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026139 Vd NA 2.633 L/kg 1compartment NA NA Human Human +DTXSID4026137 TK.Half.Life NA 4.002 hours 1compartment NA NA Rat Human +DTXSID4026137 Css NA 0.2392 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026137 Css NA 1.858 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026137 Css NA 0.1392 mg/L PBTK NA 50% Rat Human +DTXSID4026137 Css NA 1.057 mg/L PBTK NA 95% Rat Human +DTXSID4026139 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026139 Fup 0.0961 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026139 Vd NA 0.6104 L/kg 1compartment NA NA Human Human DTXSID4026139 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026139 TK.Half.Life NA 10.86 hours 1compartment NA NA Human Human -DTXSID4026139 Css NA 0.46 mg/L 3compartmentss NA 50% Human Human -DTXSID4026139 Css NA 2.963 mg/L 3compartmentss NA 95% Human Human -DTXSID4026139 Css NA 0.3176 mg/L PBTK NA 50% Human Human -DTXSID4026139 Css NA 1.998 mg/L PBTK NA 95% Human Human -DTXSID4026139 Clint NA 27.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026139 Fup NA 0.0984 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026139 Vd NA 1.983 L/kg 1compartment NA NA Rat Human +DTXSID4026139 TK.Half.Life NA 1.612 hours 1compartment NA NA Human Human +DTXSID4026139 Css NA 0.2901 mg/L 3compartmentss NA 50% Human Human +DTXSID4026139 Css NA 2.397 mg/L 3compartmentss NA 95% Human Human +DTXSID4026139 Css NA 0.1841 mg/L PBTK NA 50% Human Human +DTXSID4026139 Css NA 1.437 mg/L PBTK NA 95% Human Human +DTXSID4026139 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026139 Fup 0.0961 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026139 Vd NA 0.5108 L/kg 1compartment NA NA Rat Human DTXSID4026139 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026139 TK.Half.Life NA 2.659 hours 1compartment NA NA Rat Human -DTXSID4026139 Css NA 0.2573 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026139 Css NA 1.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026139 Css NA 0.1689 mg/L PBTK NA 50% Rat Human -DTXSID4026139 Css NA 0.8239 mg/L PBTK NA 95% Rat Human -DTXSID4026181 Clint NA 60.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026181 Fup NA 0.0031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026181 Vd NA 0.8682 L/kg 1compartment NA NA Human Human -DTXSID4026181 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4026181 TK.Half.Life NA 11.99 hours 1compartment NA NA Human Human -DTXSID4026181 Css NA 2.411 mg/L 3compartmentss NA 50% Human Human -DTXSID4026181 Css NA 20.91 mg/L 3compartmentss NA 95% Human Human -DTXSID4026181 Css NA 1.44 mg/L PBTK NA 50% Human Human -DTXSID4026181 Css NA 12.16 mg/L PBTK NA 95% Human Human -DTXSID4026181 Clint NA 60.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026181 Fup NA 0.0031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026181 Vd NA 0.6365 L/kg 1compartment NA NA Rat Human -DTXSID4026181 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026181 TK.Half.Life NA 5.436 hours 1compartment NA NA Rat Human -DTXSID4026181 Css NA 1.393 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026181 Css NA 9.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026181 Css NA 0.7756 mg/L PBTK NA 50% Rat Human -DTXSID4026181 Css NA 5.123 mg/L PBTK NA 95% Rat Human -DTXSID4026212 Clint NA 5.236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026212 Fup NA 0.0392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026212 Vd NA 2.367 L/kg 1compartment NA NA Human Human -DTXSID4026212 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID4026212 TK.Half.Life NA 65.95 hours 1compartment NA NA Human Human -DTXSID4026212 Css NA 4.197 mg/L 3compartmentss NA 50% Human Human -DTXSID4026212 Css NA 26.05 mg/L 3compartmentss NA 95% Human Human -DTXSID4026212 Css NA 2.794 mg/L PBTK NA 50% Human Human -DTXSID4026212 Css NA 16.49 mg/L PBTK NA 95% Human Human -DTXSID4026212 Clint NA 5.236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026212 Fup NA 0.0392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026212 Vd NA 1.77 L/kg 1compartment NA NA Rat Human -DTXSID4026212 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID4026212 TK.Half.Life NA 16.82 hours 1compartment NA NA Rat Human -DTXSID4026212 Css NA 2.237 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026212 Css NA 10.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026212 Css NA 1.404 mg/L PBTK NA 50% Rat Human -DTXSID4026212 Css NA 6.106 mg/L PBTK NA 95% Rat Human -DTXSID4026214 Clint NA 6.154 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026214 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026214 Vd NA 2.812 L/kg 1compartment NA NA Human Human -DTXSID4026214 Days.Css NA 31 Days PBTK NA NA Human Human -DTXSID4026214 TK.Half.Life NA 163.9 hours 1compartment NA NA Human Human -DTXSID4026214 Css NA 8.079 mg/L 3compartmentss NA 50% Human Human -DTXSID4026214 Css NA 51.03 mg/L 3compartmentss NA 95% Human Human -DTXSID4026214 Css NA 5.454 mg/L PBTK NA 50% Human Human -DTXSID4026214 Css NA 33.53 mg/L PBTK NA 95% Human Human -DTXSID4026214 Clint NA 6.154 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026214 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026214 Vd NA 2.102 L/kg 1compartment NA NA Rat Human -DTXSID4026214 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID4026214 TK.Half.Life NA 30.33 hours 1compartment NA NA Rat Human -DTXSID4026214 Css NA 4.46 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026214 Css NA 21.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026214 Css NA 2.871 mg/L PBTK NA 50% Rat Human -DTXSID4026214 Css NA 13.38 mg/L PBTK NA 95% Rat Human +DTXSID4026139 TK.Half.Life NA 0.7882 hours 1compartment NA NA Rat Human +DTXSID4026139 Css NA 0.03803 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026139 Css NA 0.2384 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026139 Css NA 0.02336 mg/L PBTK NA 50% Rat Human +DTXSID4026139 Css NA 0.1398 mg/L PBTK NA 95% Rat Human +DTXSID4026181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026181 Fup 0.00367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026181 Vd NA 2.44 L/kg 1compartment NA NA Human Human +DTXSID4026181 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID4026181 TK.Half.Life NA 63.65 hours 1compartment NA NA Human Human +DTXSID4026181 Css NA 3.739 mg/L 3compartmentss NA 50% Human Human +DTXSID4026181 Css NA 26.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4026181 Css NA 2.423 mg/L PBTK NA 50% Human Human +DTXSID4026181 Css NA 16.6 mg/L PBTK NA 95% Human Human +DTXSID4026181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026181 Fup 0.00367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026181 Vd NA 1.813 L/kg 1compartment NA NA Rat Human +DTXSID4026181 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4026181 TK.Half.Life NA 16.07 hours 1compartment NA NA Rat Human +DTXSID4026181 Css NA 0.4938 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026181 Css NA 2.883 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026181 Css NA 0.3154 mg/L PBTK NA 50% Rat Human +DTXSID4026181 Css NA 1.803 mg/L PBTK NA 95% Rat Human +DTXSID4026183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026183 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026183 Vd NA 2.432 L/kg 1compartment NA NA Human Human +DTXSID4026183 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4026183 TK.Half.Life NA 2.453 hours 1compartment NA NA Human Human +DTXSID4026183 Css NA 0.04072 mg/L 3compartmentss NA 50% Human Human +DTXSID4026183 Css NA 0.3522 mg/L 3compartmentss NA 95% Human Human +DTXSID4026183 Css NA 0.04394 mg/L PBTK NA 50% Human Human +DTXSID4026183 Css NA 0.3085 mg/L PBTK NA 95% Human Human +DTXSID4026183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026183 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026183 Vd NA 2.395 L/kg 1compartment NA NA Rat Human +DTXSID4026183 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4026183 TK.Half.Life NA 1.352 hours 1compartment NA NA Rat Human +DTXSID4026183 Css NA 0.005041 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026183 Css NA 0.03352 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026183 Css NA 0.005598 mg/L PBTK NA 50% Rat Human +DTXSID4026183 Css NA 0.02957 mg/L PBTK NA 95% Rat Human +DTXSID4026212 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026212 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026212 Vd NA 1.523 L/kg 1compartment NA NA Human Human +DTXSID4026212 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4026212 TK.Half.Life NA 22.25 hours 1compartment NA NA Human Human +DTXSID4026212 Css NA 2.342 mg/L 3compartmentss NA 50% Human Human +DTXSID4026212 Css NA 21.24 mg/L 3compartmentss NA 95% Human Human +DTXSID4026212 Css NA 1.466 mg/L PBTK NA 50% Human Human +DTXSID4026212 Css NA 12.76 mg/L PBTK NA 95% Human Human +DTXSID4026212 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026212 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026212 Vd NA 1.123 L/kg 1compartment NA NA Rat Human +DTXSID4026212 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4026212 TK.Half.Life NA 8.488 hours 1compartment NA NA Rat Human +DTXSID4026212 Css NA 0.3067 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026212 Css NA 2.347 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026212 Css NA 0.1858 mg/L PBTK NA 50% Rat Human +DTXSID4026212 Css NA 1.351 mg/L PBTK NA 95% Rat Human +DTXSID4026214 Clint 9.45 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID4026214 Fup 0.0049 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026214 Vd NA 1.85 L/kg 1compartment NA NA Human Human +DTXSID4026214 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID4026214 TK.Half.Life NA 94.29 hours 1compartment NA NA Human Human +DTXSID4026214 Css NA 8.292 mg/L 3compartmentss NA 50% Human Human +DTXSID4026214 Css NA 69.24 mg/L 3compartmentss NA 95% Human Human +DTXSID4026214 Css NA 5.23 mg/L PBTK NA 50% Human Human +DTXSID4026214 Css NA 42.57 mg/L PBTK NA 95% Human Human +DTXSID4026214 Clint 9.45 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human +DTXSID4026214 Fup 0.0049 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026214 Vd NA 1.365 L/kg 1compartment NA NA Rat Human +DTXSID4026214 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4026214 TK.Half.Life NA 8.478 hours 1compartment NA NA Rat Human +DTXSID4026214 Css NA 0.2773 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026214 Css NA 2.094 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026214 Css NA 0.1692 mg/L PBTK NA 50% Rat Human +DTXSID4026214 Css NA 1.247 mg/L PBTK NA 95% Rat Human DTXSID4026262 Clint 180 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4026262 Fup 0.402 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4026262 Vd NA 0.4997 L/kg 1compartment NA NA Human Human +DTXSID4026262 Vd NA 0.4723 L/kg 1compartment NA NA Human Human DTXSID4026262 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026262 TK.Half.Life NA 0.3995 hours 1compartment NA NA Human Human -DTXSID4026262 Css NA 0.006626 mg/L 3compartmentss NA 50% Human Human -DTXSID4026262 Css NA 0.05112 mg/L 3compartmentss NA 95% Human Human -DTXSID4026262 Css NA 0.004754 mg/L PBTK NA 50% Human Human -DTXSID4026262 Css NA 0.03382 mg/L PBTK NA 95% Human Human +DTXSID4026262 TK.Half.Life NA 0.3804 hours 1compartment NA NA Human Human +DTXSID4026262 Css NA 0.004682 mg/L 3compartmentss NA 50% Human Human +DTXSID4026262 Css NA 0.04675 mg/L 3compartmentss NA 95% Human Human +DTXSID4026262 Css NA 0.003318 mg/L PBTK NA 50% Human Human +DTXSID4026262 Css NA 0.0311 mg/L PBTK NA 95% Human Human DTXSID4026262 Clint 180 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4026262 Fup 0.402 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4026262 Vd NA 0.5084 L/kg 1compartment NA NA Rat Human +DTXSID4026262 Vd NA 0.4855 L/kg 1compartment NA NA Rat Human DTXSID4026262 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026262 TK.Half.Life NA 0.1822 hours 1compartment NA NA Rat Human -DTXSID4026262 Css NA 0.003601 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026262 Css NA 0.02336 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026262 Css NA 0.002472 mg/L PBTK NA 50% Rat Human -DTXSID4026262 Css NA 0.01484 mg/L PBTK NA 95% Rat Human -DTXSID4026266 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026266 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026266 Vd NA 0.8048 L/kg 1compartment NA NA Human Human +DTXSID4026262 TK.Half.Life NA 0.1753 hours 1compartment NA NA Rat Human +DTXSID4026262 Css NA 0.000577 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026262 Css NA 0.005083 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026262 Css NA 0.0004136 mg/L PBTK NA 50% Rat Human +DTXSID4026262 Css NA 0.003329 mg/L PBTK NA 95% Rat Human +DTXSID4026264 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026264 Fup 0.036 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026264 Vd NA 3.124 L/kg 1compartment NA NA Human Human +DTXSID4026264 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID4026264 TK.Half.Life NA 87.42 hours 1compartment NA NA Human Human +DTXSID4026264 Css NA 3.26 mg/L 3compartmentss NA 50% Human Human +DTXSID4026264 Css NA 20.31 mg/L 3compartmentss NA 95% Human Human +DTXSID4026264 Css NA 2.256 mg/L PBTK NA 50% Human Human +DTXSID4026264 Css NA 13.77 mg/L PBTK NA 95% Human Human +DTXSID4026264 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026264 Fup 0.036 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026264 Vd NA 2.341 L/kg 1compartment NA NA Rat Human +DTXSID4026264 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID4026264 TK.Half.Life NA 11.72 hours 1compartment NA NA Rat Human +DTXSID4026264 Css NA 0.4256 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026264 Css NA 2.241 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026264 Css NA 0.2937 mg/L PBTK NA 50% Rat Human +DTXSID4026264 Css NA 1.543 mg/L PBTK NA 95% Rat Human +DTXSID4026266 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026266 Fup 0.551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026266 Vd NA 0.5228 L/kg 1compartment NA NA Human Human DTXSID4026266 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026266 TK.Half.Life NA 5.212 hours 1compartment NA NA Human Human -DTXSID4026266 Css NA 0.8202 mg/L 3compartmentss NA 50% Human Human -DTXSID4026266 Css NA 5.488 mg/L 3compartmentss NA 95% Human Human -DTXSID4026266 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID4026266 Css NA 3.549 mg/L PBTK NA 95% Human Human -DTXSID4026266 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026266 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026266 Vd NA 0.839 L/kg 1compartment NA NA Rat Human +DTXSID4026266 TK.Half.Life NA 6.139 hours 1compartment NA NA Human Human +DTXSID4026266 Css NA 0.7428 mg/L 3compartmentss NA 50% Human Human +DTXSID4026266 Css NA 4.99 mg/L 3compartmentss NA 95% Human Human +DTXSID4026266 Css NA 0.5644 mg/L PBTK NA 50% Human Human +DTXSID4026266 Css NA 3.057 mg/L PBTK NA 95% Human Human +DTXSID4026266 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026266 Fup 0.551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026266 Vd NA 0.5519 L/kg 1compartment NA NA Rat Human DTXSID4026266 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026266 TK.Half.Life NA 1.85 hours 1compartment NA NA Rat Human -DTXSID4026266 Css NA 0.2063 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026266 Css NA 1.296 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026266 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID4026266 Css NA 0.7835 mg/L PBTK NA 95% Rat Human +DTXSID4026266 TK.Half.Life NA 2.209 hours 1compartment NA NA Rat Human +DTXSID4026266 Css NA 0.003912 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026266 Css NA 0.02669 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026266 Css NA 0.002838 mg/L PBTK NA 50% Rat Human +DTXSID4026266 Css NA 0.0159 mg/L PBTK NA 95% Rat Human DTXSID4026268 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4026268 Fup NA 0.0279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026268 Vd NA 1.95 L/kg 1compartment NA NA Human Human -DTXSID4026268 Days.Css NA 216 Days PBTK NA NA Human Human -DTXSID4026268 TK.Half.Life NA 851.7 hours 1compartment NA NA Human Human -DTXSID4026268 Css NA 64.85 mg/L 3compartmentss NA 50% Human Human -DTXSID4026268 Css NA 295.7 mg/L 3compartmentss NA 95% Human Human -DTXSID4026268 Css NA 41.83 mg/L PBTK NA 50% Human Human -DTXSID4026268 Css NA 174.6 mg/L PBTK NA 95% Human Human +DTXSID4026268 Vd NA 0.178 L/kg 1compartment NA NA Human Human +DTXSID4026268 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID4026268 TK.Half.Life NA 41.28 hours 1compartment NA NA Human Human +DTXSID4026268 Css NA 34.07 mg/L 3compartmentss NA 50% Human Human +DTXSID4026268 Css NA 213.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4026268 Css NA 20.02 mg/L PBTK NA 50% Human Human +DTXSID4026268 Css NA 121.6 mg/L PBTK NA 95% Human Human DTXSID4026268 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4026268 Fup NA 0.0279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026268 Vd NA 1.45 L/kg 1compartment NA NA Rat Human -DTXSID4026268 Days.Css NA 51 Days PBTK NA NA Rat Human -DTXSID4026268 TK.Half.Life NA 138.7 hours 1compartment NA NA Rat Human -DTXSID4026268 Css NA 17.83 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026268 Css NA 71.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026268 Css NA 10.82 mg/L PBTK NA 50% Rat Human -DTXSID4026268 Css NA 39.81 mg/L PBTK NA 95% Rat Human +DTXSID4026268 Vd NA 0.179 L/kg 1compartment NA NA Rat Human +DTXSID4026268 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4026268 TK.Half.Life NA 14.15 hours 1compartment NA NA Rat Human +DTXSID4026268 Css NA 0.6394 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026268 Css NA 5.153 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026268 Css NA 0.3536 mg/L PBTK NA 50% Rat Human +DTXSID4026268 Css NA 2.863 mg/L PBTK NA 95% Rat Human DTXSID4026422 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4026422 Fup NA 0.5428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026422 Vd NA 0.5657 L/kg 1compartment NA NA Human Human +DTXSID4026422 Vd NA 0.5063 L/kg 1compartment NA NA Human Human DTXSID4026422 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026422 TK.Half.Life NA 6.743 hours 1compartment NA NA Human Human -DTXSID4026422 Css NA 1.383 mg/L 3compartmentss NA 50% Human Human -DTXSID4026422 Css NA 8.515 mg/L 3compartmentss NA 95% Human Human -DTXSID4026422 Css NA 1.059 mg/L PBTK NA 50% Human Human -DTXSID4026422 Css NA 5.301 mg/L PBTK NA 95% Human Human +DTXSID4026422 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human +DTXSID4026422 Css NA 1.19 mg/L 3compartmentss NA 50% Human Human +DTXSID4026422 Css NA 7.328 mg/L 3compartmentss NA 95% Human Human +DTXSID4026422 Css NA 0.8937 mg/L PBTK NA 50% Human Human +DTXSID4026422 Css NA 4.606 mg/L PBTK NA 95% Human Human DTXSID4026422 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4026422 Fup NA 0.5428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026422 Vd NA 0.5882 L/kg 1compartment NA NA Rat Human +DTXSID4026422 Vd NA 0.5363 L/kg 1compartment NA NA Rat Human DTXSID4026422 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026422 TK.Half.Life NA 2.39 hours 1compartment NA NA Rat Human -DTXSID4026422 Css NA 0.3678 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026422 Css NA 2.039 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026422 Css NA 0.27 mg/L PBTK NA 50% Rat Human -DTXSID4026422 Css NA 1.191 mg/L PBTK NA 95% Rat Human +DTXSID4026422 TK.Half.Life NA 2.179 hours 1compartment NA NA Rat Human +DTXSID4026422 Css NA 0.02253 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026422 Css NA 0.1765 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026422 Css NA 0.01633 mg/L PBTK NA 50% Rat Human +DTXSID4026422 Css NA 0.1098 mg/L PBTK NA 95% Rat Human DTXSID4026472 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4026472 Fup NA 0.9155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026472 Vd NA 1.763 L/kg 1compartment NA NA Human Human +DTXSID4026472 Vd NA 1.784 L/kg 1compartment NA NA Human Human DTXSID4026472 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4026472 TK.Half.Life NA 15.35 hours 1compartment NA NA Human Human -DTXSID4026472 Css NA 0.8306 mg/L 3compartmentss NA 50% Human Human -DTXSID4026472 Css NA 3.254 mg/L 3compartmentss NA 95% Human Human -DTXSID4026472 Css NA 0.7974 mg/L PBTK NA 50% Human Human -DTXSID4026472 Css NA 2.476 mg/L PBTK NA 95% Human Human +DTXSID4026472 TK.Half.Life NA 15.67 hours 1compartment NA NA Human Human +DTXSID4026472 Css NA 0.7073 mg/L 3compartmentss NA 50% Human Human +DTXSID4026472 Css NA 2.785 mg/L 3compartmentss NA 95% Human Human +DTXSID4026472 Css NA 0.681 mg/L PBTK NA 50% Human Human +DTXSID4026472 Css NA 2.154 mg/L PBTK NA 95% Human Human DTXSID4026472 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4026472 Fup NA 0.9155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026472 Vd NA 1.546 L/kg 1compartment NA NA Rat Human +DTXSID4026472 Vd NA 1.56 L/kg 1compartment NA NA Rat Human DTXSID4026472 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026472 TK.Half.Life NA 3.927 hours 1compartment NA NA Rat Human -DTXSID4026472 Css NA 0.2135 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026472 Css NA 0.8385 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026472 Css NA 0.2037 mg/L PBTK NA 50% Rat Human -DTXSID4026472 Css NA 0.5757 mg/L PBTK NA 95% Rat Human -DTXSID4026505 Clint NA 10.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026505 Fup NA 0.2322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026505 Vd NA 0.5079 L/kg 1compartment NA NA Human Human -DTXSID4026505 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026505 TK.Half.Life NA 1.119 hours 1compartment NA NA Human Human -DTXSID4026505 Css NA 0.1883 mg/L 3compartmentss NA 50% Human Human -DTXSID4026505 Css NA 1.167 mg/L 3compartmentss NA 95% Human Human -DTXSID4026505 Css NA 0.1283 mg/L PBTK NA 50% Human Human -DTXSID4026505 Css NA 0.754 mg/L PBTK NA 95% Human Human -DTXSID4026505 Clint NA 10.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026505 Fup NA 0.2322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026505 Vd NA 0.4866 L/kg 1compartment NA NA Rat Human +DTXSID4026472 TK.Half.Life NA 3.974 hours 1compartment NA NA Rat Human +DTXSID4026472 Css NA 0.01264 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026472 Css NA 0.07447 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026472 Css NA 0.01187 mg/L PBTK NA 50% Rat Human +DTXSID4026472 Css NA 0.05893 mg/L PBTK NA 95% Rat Human +DTXSID4026505 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026505 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026505 Vd NA 0.3883 L/kg 1compartment NA NA Human Human +DTXSID4026505 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4026505 TK.Half.Life NA 12.71 hours 1compartment NA NA Human Human +DTXSID4026505 Css NA 3.917 mg/L 3compartmentss NA 50% Human Human +DTXSID4026505 Css NA 13.71 mg/L 3compartmentss NA 95% Human Human +DTXSID4026505 Css NA 2.584 mg/L PBTK NA 50% Human Human +DTXSID4026505 Css NA 8.378 mg/L PBTK NA 95% Human Human +DTXSID4026505 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026505 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026505 Vd NA 0.388 L/kg 1compartment NA NA Rat Human DTXSID4026505 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026505 TK.Half.Life NA 0.6129 hours 1compartment NA NA Rat Human -DTXSID4026505 Css NA 0.1011 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026505 Css NA 0.4865 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026505 Css NA 0.06526 mg/L PBTK NA 50% Rat Human -DTXSID4026505 Css NA 0.2894 mg/L PBTK NA 95% Rat Human -DTXSID4026557 Clint NA 25.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026557 Fup NA 0.2744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026557 Vd NA 0.9064 L/kg 1compartment NA NA Human Human +DTXSID4026505 TK.Half.Life NA 4.321 hours 1compartment NA NA Rat Human +DTXSID4026505 Css NA 0.2532 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026505 Css NA 0.7694 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026505 Css NA 0.163 mg/L PBTK NA 50% Rat Human +DTXSID4026505 Css NA 0.4531 mg/L PBTK NA 95% Rat Human +DTXSID4026557 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026557 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026557 Vd NA 1.23 L/kg 1compartment NA NA Human Human DTXSID4026557 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026557 TK.Half.Life NA 1.173 hours 1compartment NA NA Human Human -DTXSID4026557 Css NA 0.06919 mg/L 3compartmentss NA 50% Human Human -DTXSID4026557 Css NA 0.4991 mg/L 3compartmentss NA 95% Human Human -DTXSID4026557 Css NA 0.0506 mg/L PBTK NA 50% Human Human -DTXSID4026557 Css NA 0.3313 mg/L PBTK NA 95% Human Human -DTXSID4026557 Clint NA 25.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026557 Fup NA 0.2744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026557 Vd NA 0.7847 L/kg 1compartment NA NA Rat Human +DTXSID4026557 TK.Half.Life NA 2.557 hours 1compartment NA NA Human Human +DTXSID4026557 Css NA 0.1615 mg/L 3compartmentss NA 50% Human Human +DTXSID4026557 Css NA 1.031 mg/L 3compartmentss NA 95% Human Human +DTXSID4026557 Css NA 0.1274 mg/L PBTK NA 50% Human Human +DTXSID4026557 Css NA 0.7286 mg/L PBTK NA 95% Human Human +DTXSID4026557 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026557 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026557 Vd NA 1.054 L/kg 1compartment NA NA Rat Human DTXSID4026557 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026557 TK.Half.Life NA 0.5271 hours 1compartment NA NA Rat Human -DTXSID4026557 Css NA 0.03785 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026557 Css NA 0.2042 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026557 Css NA 0.02632 mg/L PBTK NA 50% Rat Human -DTXSID4026557 Css NA 0.1305 mg/L PBTK NA 95% Rat Human +DTXSID4026557 TK.Half.Life NA 1.152 hours 1compartment NA NA Rat Human +DTXSID4026557 Css NA 0.01888 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026557 Css NA 0.09252 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026557 Css NA 0.01503 mg/L PBTK NA 50% Rat Human +DTXSID4026557 Css NA 0.06303 mg/L PBTK NA 95% Rat Human DTXSID4026684 Clint 14.36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4026684 Fup 0.009805 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID4026684 Vd NA 2.283 L/kg 1compartment NA NA Human Human -DTXSID4026684 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID4026684 TK.Half.Life NA 56.45 hours 1compartment NA NA Human Human -DTXSID4026684 Css NA 3.83 mg/L 3compartmentss NA 50% Human Human -DTXSID4026684 Css NA 28.46 mg/L 3compartmentss NA 95% Human Human -DTXSID4026684 Css NA 2.496 mg/L PBTK NA 50% Human Human -DTXSID4026684 Css NA 17.68 mg/L PBTK NA 95% Human Human +DTXSID4026684 Vd NA 2.931 L/kg 1compartment NA NA Human Human +DTXSID4026684 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID4026684 TK.Half.Life NA 100.3 hours 1compartment NA NA Human Human +DTXSID4026684 Css NA 4.444 mg/L 3compartmentss NA 50% Human Human +DTXSID4026684 Css NA 29.04 mg/L 3compartmentss NA 95% Human Human +DTXSID4026684 Css NA 3.038 mg/L PBTK NA 50% Human Human +DTXSID4026684 Css NA 19.09 mg/L PBTK NA 95% Human Human DTXSID4026684 Clint 14.36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4026684 Fup 0.009805 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID4026684 Vd NA 1.697 L/kg 1compartment NA NA Rat Human -DTXSID4026684 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID4026684 TK.Half.Life NA 15.62 hours 1compartment NA NA Rat Human -DTXSID4026684 Css NA 2.124 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026684 Css NA 13.35 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026684 Css NA 1.31 mg/L PBTK NA 50% Rat Human -DTXSID4026684 Css NA 7.678 mg/L PBTK NA 95% Rat Human -DTXSID4026921 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026921 Fup NA 0.4016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026921 Vd NA 1.656 L/kg 1compartment NA NA Human Human -DTXSID4026921 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4026921 TK.Half.Life NA 29.74 hours 1compartment NA NA Human Human -DTXSID4026921 Css NA 1.756 mg/L 3compartmentss NA 50% Human Human -DTXSID4026921 Css NA 7.607 mg/L 3compartmentss NA 95% Human Human -DTXSID4026921 Css NA 1.503 mg/L PBTK NA 50% Human Human -DTXSID4026921 Css NA 5.275 mg/L PBTK NA 95% Human Human -DTXSID4026921 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026921 Fup NA 0.4016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026921 Vd NA 1.526 L/kg 1compartment NA NA Rat Human +DTXSID4026684 Vd NA 2.192 L/kg 1compartment NA NA Rat Human +DTXSID4026684 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID4026684 TK.Half.Life NA 16.86 hours 1compartment NA NA Rat Human +DTXSID4026684 Css NA 0.5721 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026684 Css NA 3.299 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026684 Css NA 0.3843 mg/L PBTK NA 50% Rat Human +DTXSID4026684 Css NA 2.174 mg/L PBTK NA 95% Rat Human +DTXSID4026713 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026713 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026713 Vd NA 4.487 L/kg 1compartment NA NA Human Human +DTXSID4026713 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4026713 TK.Half.Life NA 2.728 hours 1compartment NA NA Human Human +DTXSID4026713 Css NA 0.01765 mg/L 3compartmentss NA 50% Human Human +DTXSID4026713 Css NA 0.2573 mg/L 3compartmentss NA 95% Human Human +DTXSID4026713 Css NA 0.02499 mg/L PBTK NA 50% Human Human +DTXSID4026713 Css NA 0.2316 mg/L PBTK NA 95% Human Human +DTXSID4026713 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026713 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026713 Vd NA 4.587 L/kg 1compartment NA NA Rat Human +DTXSID4026713 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4026713 TK.Half.Life NA 1.473 hours 1compartment NA NA Rat Human +DTXSID4026713 Css NA 0.002098 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026713 Css NA 0.02779 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026713 Css NA 0.00313 mg/L PBTK NA 50% Rat Human +DTXSID4026713 Css NA 0.02348 mg/L PBTK NA 95% Rat Human +DTXSID4026921 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026921 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026921 Vd NA 1.916 L/kg 1compartment NA NA Human Human +DTXSID4026921 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4026921 TK.Half.Life NA 27.6 hours 1compartment NA NA Human Human +DTXSID4026921 Css NA 1.296 mg/L 3compartmentss NA 50% Human Human +DTXSID4026921 Css NA 7.291 mg/L 3compartmentss NA 95% Human Human +DTXSID4026921 Css NA 1.19 mg/L PBTK NA 50% Human Human +DTXSID4026921 Css NA 4.967 mg/L PBTK NA 95% Human Human +DTXSID4026921 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026921 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026921 Vd NA 1.772 L/kg 1compartment NA NA Rat Human DTXSID4026921 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026921 TK.Half.Life NA 8.606 hours 1compartment NA NA Rat Human -DTXSID4026921 Css NA 0.4671 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026921 Css NA 1.81 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026921 Css NA 0.3883 mg/L PBTK NA 50% Rat Human -DTXSID4026921 Css NA 1.154 mg/L PBTK NA 95% Rat Human -DTXSID4026927 Clint NA 47.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026927 Fup NA 0.0506 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026927 Vd NA 3.377 L/kg 1compartment NA NA Human Human -DTXSID4026927 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026927 TK.Half.Life NA 3.062 hours 1compartment NA NA Human Human -DTXSID4026927 Css NA 0.03481 mg/L 3compartmentss NA 50% Human Human -DTXSID4026927 Css NA 0.2929 mg/L 3compartmentss NA 95% Human Human -DTXSID4026927 Css NA 0.02978 mg/L PBTK NA 50% Human Human -DTXSID4026927 Css NA 0.2154 mg/L PBTK NA 95% Human Human -DTXSID4026927 Clint NA 47.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026927 Fup NA 0.0506 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026927 Vd NA 2.991 L/kg 1compartment NA NA Rat Human -DTXSID4026927 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026927 TK.Half.Life NA 1.186 hours 1compartment NA NA Rat Human -DTXSID4026927 Css NA 0.01952 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026927 Css NA 0.1314 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026927 Css NA 0.0162 mg/L PBTK NA 50% Rat Human -DTXSID4026927 Css NA 0.09522 mg/L PBTK NA 95% Rat Human -DTXSID4026975 Clint NA 0.2001 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026975 Fup NA 0.2311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026975 Vd NA 0.4455 L/kg 1compartment NA NA Human Human +DTXSID4026921 TK.Half.Life NA 7.853 hours 1compartment NA NA Rat Human +DTXSID4026921 Css NA 0.08122 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026921 Css NA 0.4166 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026921 Css NA 0.07498 mg/L PBTK NA 50% Rat Human +DTXSID4026921 Css NA 0.2745 mg/L PBTK NA 95% Rat Human +DTXSID4026975 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026975 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4026975 Vd NA 0.3916 L/kg 1compartment NA NA Human Human DTXSID4026975 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026975 TK.Half.Life NA 9.34 hours 1compartment NA NA Human Human -DTXSID4026975 Css NA 2.452 mg/L 3compartmentss NA 50% Human Human -DTXSID4026975 Css NA 9.258 mg/L 3compartmentss NA 95% Human Human -DTXSID4026975 Css NA 1.678 mg/L PBTK NA 50% Human Human -DTXSID4026975 Css NA 5.702 mg/L PBTK NA 95% Human Human -DTXSID4026975 Clint NA 0.2001 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026975 Fup NA 0.2311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026975 Vd NA 0.4501 L/kg 1compartment NA NA Rat Human +DTXSID4026975 TK.Half.Life NA 8.362 hours 1compartment NA NA Human Human +DTXSID4026975 Css NA 2.466 mg/L 3compartmentss NA 50% Human Human +DTXSID4026975 Css NA 9.76 mg/L 3compartmentss NA 95% Human Human +DTXSID4026975 Css NA 1.691 mg/L PBTK NA 50% Human Human +DTXSID4026975 Css NA 6.023 mg/L PBTK NA 95% Human Human +DTXSID4026975 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026975 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4026975 Vd NA 0.4094 L/kg 1compartment NA NA Rat Human DTXSID4026975 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026975 TK.Half.Life NA 3.691 hours 1compartment NA NA Rat Human -DTXSID4026975 Css NA 0.789 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026975 Css NA 2.571 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026975 Css NA 0.5142 mg/L PBTK NA 50% Rat Human -DTXSID4026975 Css NA 1.484 mg/L PBTK NA 95% Rat Human +DTXSID4026975 TK.Half.Life NA 2.979 hours 1compartment NA NA Rat Human +DTXSID4026975 Css NA 0.1605 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026975 Css NA 0.5258 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026975 Css NA 0.1075 mg/L PBTK NA 50% Rat Human +DTXSID4026975 Css NA 0.3141 mg/L PBTK NA 95% Rat Human DTXSID4026979 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4026979 Fup NA 0.79 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4026979 Vd NA 0.7812 L/kg 1compartment NA NA Human Human +DTXSID4026979 Vd NA 0.8002 L/kg 1compartment NA NA Human Human DTXSID4026979 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4026979 TK.Half.Life NA 6.418 hours 1compartment NA NA Human Human -DTXSID4026979 Css NA 1.002 mg/L 3compartmentss NA 50% Human Human -DTXSID4026979 Css NA 5.874 mg/L 3compartmentss NA 95% Human Human -DTXSID4026979 Css NA 0.8322 mg/L PBTK NA 50% Human Human -DTXSID4026979 Css NA 3.82 mg/L PBTK NA 95% Human Human +DTXSID4026979 TK.Half.Life NA 6.583 hours 1compartment NA NA Human Human +DTXSID4026979 Css NA 0.9666 mg/L 3compartmentss NA 50% Human Human +DTXSID4026979 Css NA 5.745 mg/L 3compartmentss NA 95% Human Human +DTXSID4026979 Css NA 0.8066 mg/L PBTK NA 50% Human Human +DTXSID4026979 Css NA 3.728 mg/L PBTK NA 95% Human Human DTXSID4026979 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4026979 Fup NA 0.79 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4026979 Vd NA 0.7974 L/kg 1compartment NA NA Rat Human +DTXSID4026979 Vd NA 0.8133 L/kg 1compartment NA NA Rat Human DTXSID4026979 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4026979 TK.Half.Life NA 2.228 hours 1compartment NA NA Rat Human -DTXSID4026979 Css NA 0.251 mg/L 3compartmentss NA 50% Rat Human -DTXSID4026979 Css NA 1.526 mg/L 3compartmentss NA 95% Rat Human -DTXSID4026979 Css NA 0.2031 mg/L PBTK NA 50% Rat Human -DTXSID4026979 Css NA 0.9153 mg/L PBTK NA 95% Rat Human -DTXSID4027026 Clint NA 92.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027026 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027026 Vd NA 2.909 L/kg 1compartment NA NA Human Human -DTXSID4027026 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027026 TK.Half.Life NA 2.576 hours 1compartment NA NA Human Human -DTXSID4027026 Css NA 0.02226 mg/L 3compartmentss NA 50% Human Human -DTXSID4027026 Css NA 0.1965 mg/L 3compartmentss NA 95% Human Human -DTXSID4027026 Css NA 0.01663 mg/L PBTK NA 50% Human Human -DTXSID4027026 Css NA 0.1339 mg/L PBTK NA 95% Human Human -DTXSID4027026 Clint NA 92.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027026 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027026 Vd NA 2.412 L/kg 1compartment NA NA Rat Human -DTXSID4027026 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027026 TK.Half.Life NA 0.9197 hours 1compartment NA NA Rat Human -DTXSID4027026 Css NA 0.01234 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027026 Css NA 0.089 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027026 Css NA 0.008883 mg/L PBTK NA 50% Rat Human -DTXSID4027026 Css NA 0.05848 mg/L PBTK NA 95% Rat Human -DTXSID4027072 Clint NA 5.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027072 Fup NA 0.7682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027072 Vd NA 1.525 L/kg 1compartment NA NA Human Human +DTXSID4026979 TK.Half.Life NA 2.272 hours 1compartment NA NA Rat Human +DTXSID4026979 Css NA 0.05584 mg/L 3compartmentss NA 50% Rat Human +DTXSID4026979 Css NA 0.3525 mg/L 3compartmentss NA 95% Rat Human +DTXSID4026979 Css NA 0.04714 mg/L PBTK NA 50% Rat Human +DTXSID4026979 Css NA 0.2186 mg/L PBTK NA 95% Rat Human +DTXSID4027072 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027072 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027072 Vd NA 0.9753 L/kg 1compartment NA NA Human Human DTXSID4027072 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027072 TK.Half.Life NA 2.12 hours 1compartment NA NA Human Human -DTXSID4027072 Css NA 0.1006 mg/L 3compartmentss NA 50% Human Human -DTXSID4027072 Css NA 0.8524 mg/L 3compartmentss NA 95% Human Human -DTXSID4027072 Css NA 0.09128 mg/L PBTK NA 50% Human Human -DTXSID4027072 Css NA 0.6134 mg/L PBTK NA 95% Human Human -DTXSID4027072 Clint NA 5.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027072 Fup NA 0.7682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027072 Vd NA 1.349 L/kg 1compartment NA NA Rat Human +DTXSID4027072 TK.Half.Life NA 1.732 hours 1compartment NA NA Human Human +DTXSID4027072 Css NA 0.111 mg/L 3compartmentss NA 50% Human Human +DTXSID4027072 Css NA 0.8676 mg/L 3compartmentss NA 95% Human Human +DTXSID4027072 Css NA 0.0894 mg/L PBTK NA 50% Human Human +DTXSID4027072 Css NA 0.5835 mg/L PBTK NA 95% Human Human +DTXSID4027072 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027072 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027072 Vd NA 0.89 L/kg 1compartment NA NA Rat Human DTXSID4027072 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027072 TK.Half.Life NA 0.9374 hours 1compartment NA NA Rat Human -DTXSID4027072 Css NA 0.04852 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027072 Css NA 0.3708 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027072 Css NA 0.04318 mg/L PBTK NA 50% Rat Human -DTXSID4027072 Css NA 0.2426 mg/L PBTK NA 95% Rat Human -DTXSID4027076 Clint NA 0.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027076 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027076 Vd NA 0.3401 L/kg 1compartment NA NA Human Human -DTXSID4027076 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4027076 TK.Half.Life NA 29.99 hours 1compartment NA NA Human Human -DTXSID4027076 Css NA 15.64 mg/L 3compartmentss NA 50% Human Human -DTXSID4027076 Css NA 74.8 mg/L 3compartmentss NA 95% Human Human -DTXSID4027076 Css NA 9.401 mg/L PBTK NA 50% Human Human -DTXSID4027076 Css NA 43.05 mg/L PBTK NA 95% Human Human -DTXSID4027076 Clint NA 0.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027076 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027076 Vd NA 0.2931 L/kg 1compartment NA NA Rat Human -DTXSID4027076 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4027076 TK.Half.Life NA 11.89 hours 1compartment NA NA Rat Human -DTXSID4027076 Css NA 6.076 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027076 Css NA 25.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027076 Css NA 3.407 mg/L PBTK NA 50% Rat Human -DTXSID4027076 Css NA 13.73 mg/L PBTK NA 95% Rat Human -DTXSID4027103 Clint NA 4.247 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027103 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027103 Vd NA 7.701 L/kg 1compartment NA NA Human Human -DTXSID4027103 Days.Css NA 290 Days PBTK NA NA Human Human -DTXSID4027103 TK.Half.Life NA 1158 hours 1compartment NA NA Human Human -DTXSID4027103 Css NA 12.3 mg/L 3compartmentss NA 50% Human Human -DTXSID4027103 Css NA 69.87 mg/L 3compartmentss NA 95% Human Human -DTXSID4027103 Css NA 12.38 mg/L PBTK NA 50% Human Human -DTXSID4027103 Css NA 66.74 mg/L PBTK NA 95% Human Human -DTXSID4027103 Clint NA 4.247 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027103 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027103 Vd NA 5.993 L/kg 1compartment NA NA Rat Human -DTXSID4027103 Days.Css NA 164 Days PBTK NA NA Rat Human -DTXSID4027103 TK.Half.Life NA 155.2 hours 1compartment NA NA Rat Human -DTXSID4027103 Css NA 6.74 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027103 Css NA 27.51 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027103 Css NA 6.668 mg/L PBTK NA 50% Rat Human -DTXSID4027103 Css NA 27.26 mg/L PBTK NA 95% Rat Human -DTXSID4027109 Clint NA 126.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027109 Fup NA 0.4715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027109 Vd NA 2.908 L/kg 1compartment NA NA Human Human -DTXSID4027109 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027109 TK.Half.Life NA 1.372 hours 1compartment NA NA Human Human -DTXSID4027109 Css NA 0.004257 mg/L 3compartmentss NA 50% Human Human -DTXSID4027109 Css NA 0.04695 mg/L 3compartmentss NA 95% Human Human -DTXSID4027109 Css NA 0.005256 mg/L PBTK NA 50% Human Human -DTXSID4027109 Css NA 0.04213 mg/L PBTK NA 95% Human Human -DTXSID4027109 Clint NA 126.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027109 Fup NA 0.4715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027109 Vd NA 2.881 L/kg 1compartment NA NA Rat Human +DTXSID4027072 TK.Half.Life NA 0.8528 hours 1compartment NA NA Rat Human +DTXSID4027072 Css NA 0.003735 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027072 Css NA 0.0331 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027072 Css NA 0.002952 mg/L PBTK NA 50% Rat Human +DTXSID4027072 Css NA 0.02255 mg/L PBTK NA 95% Rat Human +DTXSID4027076 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027076 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027076 Vd NA 0.4338 L/kg 1compartment NA NA Human Human +DTXSID4027076 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4027076 TK.Half.Life NA 0.7536 hours 1compartment NA NA Human Human +DTXSID4027076 Css NA 0.1185 mg/L 3compartmentss NA 50% Human Human +DTXSID4027076 Css NA 0.8338 mg/L 3compartmentss NA 95% Human Human +DTXSID4027076 Css NA 0.07794 mg/L PBTK NA 50% Human Human +DTXSID4027076 Css NA 0.5292 mg/L PBTK NA 95% Human Human +DTXSID4027076 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027076 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027076 Vd NA 0.4261 L/kg 1compartment NA NA Rat Human +DTXSID4027076 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4027076 TK.Half.Life NA 0.4123 hours 1compartment NA NA Rat Human +DTXSID4027076 Css NA 0.01514 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027076 Css NA 0.08125 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027076 Css NA 0.00976 mg/L PBTK NA 50% Rat Human +DTXSID4027076 Css NA 0.05031 mg/L PBTK NA 95% Rat Human +DTXSID4027109 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027109 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027109 Vd NA 1.635 L/kg 1compartment NA NA Human Human +DTXSID4027109 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4027109 TK.Half.Life NA 22.75 hours 1compartment NA NA Human Human +DTXSID4027109 Css NA 1.204 mg/L 3compartmentss NA 50% Human Human +DTXSID4027109 Css NA 6.572 mg/L 3compartmentss NA 95% Human Human +DTXSID4027109 Css NA 1.145 mg/L PBTK NA 50% Human Human +DTXSID4027109 Css NA 4.618 mg/L PBTK NA 95% Human Human +DTXSID4027109 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027109 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027109 Vd NA 1.611 L/kg 1compartment NA NA Rat Human DTXSID4027109 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027109 TK.Half.Life NA 0.6296 hours 1compartment NA NA Rat Human -DTXSID4027109 Css NA 0.002216 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027109 Css NA 0.02057 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027109 Css NA 0.002742 mg/L PBTK NA 50% Rat Human -DTXSID4027109 Css NA 0.01837 mg/L PBTK NA 95% Rat Human -DTXSID4027159 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027159 Fup NA 0.8879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027159 Vd NA 0.9607 L/kg 1compartment NA NA Human Human +DTXSID4027109 TK.Half.Life NA 7.638 hours 1compartment NA NA Rat Human +DTXSID4027109 Css NA 0.07364 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027109 Css NA 0.3588 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027109 Css NA 0.07066 mg/L PBTK NA 50% Rat Human +DTXSID4027109 Css NA 0.2429 mg/L PBTK NA 95% Rat Human +DTXSID4027159 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027159 Fup 0.687 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027159 Vd NA 0.8237 L/kg 1compartment NA NA Human Human DTXSID4027159 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027159 TK.Half.Life NA 7.092 hours 1compartment NA NA Human Human -DTXSID4027159 Css NA 0.8954 mg/L 3compartmentss NA 50% Human Human -DTXSID4027159 Css NA 5.002 mg/L 3compartmentss NA 95% Human Human -DTXSID4027159 Css NA 0.7806 mg/L PBTK NA 50% Human Human -DTXSID4027159 Css NA 3.348 mg/L PBTK NA 95% Human Human -DTXSID4027159 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027159 Fup NA 0.8879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027159 Vd NA 0.9565 L/kg 1compartment NA NA Rat Human +DTXSID4027159 TK.Half.Life NA 7.838 hours 1compartment NA NA Human Human +DTXSID4027159 Css NA 1.047 mg/L 3compartmentss NA 50% Human Human +DTXSID4027159 Css NA 6.662 mg/L 3compartmentss NA 95% Human Human +DTXSID4027159 Css NA 0.8674 mg/L PBTK NA 50% Human Human +DTXSID4027159 Css NA 4.319 mg/L PBTK NA 95% Human Human +DTXSID4027159 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027159 Fup 0.687 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027159 Vd NA 0.8186 L/kg 1compartment NA NA Rat Human DTXSID4027159 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027159 TK.Half.Life NA 2.382 hours 1compartment NA NA Rat Human -DTXSID4027159 Css NA 0.2273 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027159 Css NA 1.369 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027159 Css NA 0.1928 mg/L PBTK NA 50% Rat Human -DTXSID4027159 Css NA 0.8368 mg/L PBTK NA 95% Rat Human -DTXSID4027236 Clint NA 3.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4027159 TK.Half.Life NA 2.635 hours 1compartment NA NA Rat Human +DTXSID4027159 Css NA 0.06267 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027159 Css NA 0.4082 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027159 Css NA 0.05231 mg/L PBTK NA 50% Rat Human +DTXSID4027159 Css NA 0.2518 mg/L PBTK NA 95% Rat Human +DTXSID4027236 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4027236 Fup 0.337 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4027236 Vd NA 1.328 L/kg 1compartment NA NA Human Human +DTXSID4027236 Vd NA 1.318 L/kg 1compartment NA NA Human Human DTXSID4027236 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027236 TK.Half.Life NA 5.239 hours 1compartment NA NA Human Human -DTXSID4027236 Css NA 0.3762 mg/L 3compartmentss NA 50% Human Human -DTXSID4027236 Css NA 1.829 mg/L 3compartmentss NA 95% Human Human -DTXSID4027236 Css NA 0.2916 mg/L PBTK NA 50% Human Human -DTXSID4027236 Css NA 1.288 mg/L PBTK NA 95% Human Human -DTXSID4027236 Clint NA 3.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4027236 TK.Half.Life NA 1.652 hours 1compartment NA NA Human Human +DTXSID4027236 Css NA 0.06054 mg/L 3compartmentss NA 50% Human Human +DTXSID4027236 Css NA 0.4244 mg/L 3compartmentss NA 95% Human Human +DTXSID4027236 Css NA 0.04647 mg/L PBTK NA 50% Human Human +DTXSID4027236 Css NA 0.3011 mg/L PBTK NA 95% Human Human +DTXSID4027236 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4027236 Fup 0.337 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4027236 Vd NA 1.102 L/kg 1compartment NA NA Rat Human +DTXSID4027236 Vd NA 1.095 L/kg 1compartment NA NA Rat Human DTXSID4027236 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027236 TK.Half.Life NA 2.195 hours 1compartment NA NA Rat Human -DTXSID4027236 Css NA 0.1792 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027236 Css NA 0.6391 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027236 Css NA 0.1333 mg/L PBTK NA 50% Rat Human -DTXSID4027236 Css NA 0.4093 mg/L PBTK NA 95% Rat Human -DTXSID4027280 Clint NA 3.943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027280 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027280 Vd NA 94.12 L/kg 1compartment NA NA Human Human -DTXSID4027280 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4027280 TK.Half.Life NA 15160 hours 1compartment NA NA Human Human -DTXSID4027280 Css NA 1.159 mg/L 3compartmentss NA 50% Human Human -DTXSID4027280 Css NA 7.171 mg/L 3compartmentss NA 95% Human Human -DTXSID4027280 Css NA 13.25 mg/L PBTK NA 50% Human Human -DTXSID4027280 Css NA 75.11 mg/L PBTK NA 95% Human Human -DTXSID4027280 Clint NA 3.943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027280 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027280 Vd NA 81.18 L/kg 1compartment NA NA Rat Human -DTXSID4027280 Days.Css NA 2537 Days PBTK NA NA Rat Human -DTXSID4027280 TK.Half.Life NA 2227 hours 1compartment NA NA Rat Human -DTXSID4027280 Css NA 0.5972 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027280 Css NA 2.504 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027280 Css NA 7.198 mg/L PBTK NA 50% Rat Human -DTXSID4027280 Css NA 29.01 mg/L PBTK NA 95% Rat Human +DTXSID4027236 TK.Half.Life NA 0.6856 hours 1compartment NA NA Rat Human +DTXSID4027236 Css NA 0.007688 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027236 Css NA 0.03859 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027236 Css NA 0.005915 mg/L PBTK NA 50% Rat Human +DTXSID4027236 Css NA 0.02721 mg/L PBTK NA 95% Rat Human +DTXSID4027280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027280 Fup 0.0233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027280 Vd NA 3.126 L/kg 1compartment NA NA Human Human +DTXSID4027280 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID4027280 TK.Half.Life NA 94.2 hours 1compartment NA NA Human Human +DTXSID4027280 Css NA 1.874 mg/L 3compartmentss NA 50% Human Human +DTXSID4027280 Css NA 11.91 mg/L 3compartmentss NA 95% Human Human +DTXSID4027280 Css NA 1.297 mg/L PBTK NA 50% Human Human +DTXSID4027280 Css NA 8.206 mg/L PBTK NA 95% Human Human +DTXSID4027280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027280 Fup 0.0233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027280 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID4027280 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID4027280 TK.Half.Life NA 12.54 hours 1compartment NA NA Rat Human +DTXSID4027280 Css NA 0.02034 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027280 Css NA 0.1188 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027280 Css NA 0.01355 mg/L PBTK NA 50% Rat Human +DTXSID4027280 Css NA 0.07904 mg/L PBTK NA 95% Rat Human +DTXSID4027282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027282 Fup 0.0228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027282 Vd NA 1.972 L/kg 1compartment NA NA Human Human +DTXSID4027282 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4027282 TK.Half.Life NA 18.29 hours 1compartment NA NA Human Human +DTXSID4027282 Css NA 1.19 mg/L 3compartmentss NA 50% Human Human +DTXSID4027282 Css NA 9.643 mg/L 3compartmentss NA 95% Human Human +DTXSID4027282 Css NA 0.7649 mg/L PBTK NA 50% Human Human +DTXSID4027282 Css NA 5.865 mg/L PBTK NA 95% Human Human +DTXSID4027282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027282 Fup 0.0228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027282 Vd NA 1.467 L/kg 1compartment NA NA Rat Human +DTXSID4027282 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4027282 TK.Half.Life NA 5.96 hours 1compartment NA NA Rat Human +DTXSID4027282 Css NA 0.04566 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027282 Css NA 0.4137 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027282 Css NA 0.02819 mg/L PBTK NA 50% Rat Human +DTXSID4027282 Css NA 0.2428 mg/L PBTK NA 95% Rat Human DTXSID4027284 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4027284 Fup NA 0.7455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4027284 Vd NA 0.7282 L/kg 1compartment NA NA Human Human DTXSID4027284 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4027284 TK.Half.Life NA 6.336 hours 1compartment NA NA Human Human -DTXSID4027284 Css NA 1.044 mg/L 3compartmentss NA 50% Human Human -DTXSID4027284 Css NA 6.19 mg/L 3compartmentss NA 95% Human Human -DTXSID4027284 Css NA 0.8556 mg/L PBTK NA 50% Human Human -DTXSID4027284 Css NA 4.006 mg/L PBTK NA 95% Human Human +DTXSID4027284 Css NA 0.8825 mg/L 3compartmentss NA 50% Human Human +DTXSID4027284 Css NA 5.552 mg/L 3compartmentss NA 95% Human Human +DTXSID4027284 Css NA 0.7217 mg/L PBTK NA 50% Human Human +DTXSID4027284 Css NA 3.536 mg/L PBTK NA 95% Human Human DTXSID4027284 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4027284 Fup NA 0.7455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4027284 Vd NA 0.7482 L/kg 1compartment NA NA Rat Human DTXSID4027284 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4027284 TK.Half.Life NA 2.215 hours 1compartment NA NA Rat Human -DTXSID4027284 Css NA 0.2679 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027284 Css NA 1.718 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027284 Css NA 0.2121 mg/L PBTK NA 50% Rat Human -DTXSID4027284 Css NA 1.018 mg/L PBTK NA 95% Rat Human -DTXSID4027286 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027286 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027286 Vd NA 1527 L/kg 1compartment NA NA Human Human -DTXSID4027286 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID4027286 TK.Half.Life NA 77020000 hours 1compartment NA NA Human Human -DTXSID4027286 Css NA 14.93 mg/L 3compartmentss NA 50% Human Human -DTXSID4027286 Css NA 38.57 mg/L 3compartmentss NA 95% Human Human -DTXSID4027286 Css NA 3740 mg/L PBTK NA 50% Human Human -DTXSID4027286 Css NA 7979 mg/L PBTK NA 95% Human Human -DTXSID4027286 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027286 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027286 Vd NA 1407 L/kg 1compartment NA NA Rat Human -DTXSID4027286 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID4027286 TK.Half.Life NA 5874000 hours 1compartment NA NA Rat Human -DTXSID4027286 Css NA 3.623 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027286 Css NA 6.261 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027286 Css NA 1008 mg/L PBTK NA 50% Rat Human -DTXSID4027286 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID4027319 Clint NA 0.9309 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027319 Fup NA 0.9652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027319 Vd NA 0.9849 L/kg 1compartment NA NA Human Human +DTXSID4027284 Css NA 0.01698 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027284 Css NA 0.1325 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027284 Css NA 0.01335 mg/L PBTK NA 50% Rat Human +DTXSID4027284 Css NA 0.08454 mg/L PBTK NA 95% Rat Human +DTXSID4027286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027286 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027286 Vd NA 175.5 L/kg 1compartment NA NA Human Human +DTXSID4027286 Days.Css NA 1379 Days PBTK NA NA Human Human +DTXSID4027286 TK.Half.Life NA 5142 hours 1compartment NA NA Human Human +DTXSID4027286 Css NA 0.0555 mg/L 3compartmentss NA 50% Human Human +DTXSID4027286 Css NA 0.3742 mg/L 3compartmentss NA 95% Human Human +DTXSID4027286 Css NA 1.305 mg/L PBTK NA 50% Human Human +DTXSID4027286 Css NA 7.921 mg/L PBTK NA 95% Human Human +DTXSID4027286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027286 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027286 Vd NA 154.3 L/kg 1compartment NA NA Rat Human +DTXSID4027286 Days.Css NA 862 Days PBTK NA NA Rat Human +DTXSID4027286 TK.Half.Life NA 767.8 hours 1compartment NA NA Rat Human +DTXSID4027286 Css NA 0.0005463 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027286 Css NA 0.003399 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027286 Css NA 0.0136 mg/L PBTK NA 50% Rat Human +DTXSID4027286 Css NA 0.0835 mg/L PBTK NA 95% Rat Human +DTXSID4027319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027319 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027319 Vd NA 0.7691 L/kg 1compartment NA NA Human Human DTXSID4027319 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027319 TK.Half.Life NA 2.823 hours 1compartment NA NA Human Human -DTXSID4027319 Css NA 0.3174 mg/L 3compartmentss NA 50% Human Human -DTXSID4027319 Css NA 1.275 mg/L 3compartmentss NA 95% Human Human -DTXSID4027319 Css NA 0.2786 mg/L PBTK NA 50% Human Human -DTXSID4027319 Css NA 0.9415 mg/L PBTK NA 95% Human Human -DTXSID4027319 Clint NA 0.9309 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027319 Fup NA 0.9652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027319 Vd NA 0.9871 L/kg 1compartment NA NA Rat Human +DTXSID4027319 TK.Half.Life NA 0.6671 hours 1compartment NA NA Human Human +DTXSID4027319 Css NA 0.03024 mg/L 3compartmentss NA 50% Human Human +DTXSID4027319 Css NA 0.3507 mg/L 3compartmentss NA 95% Human Human +DTXSID4027319 Css NA 0.02419 mg/L PBTK NA 50% Human Human +DTXSID4027319 Css NA 0.2344 mg/L PBTK NA 95% Human Human +DTXSID4027319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027319 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027319 Vd NA 0.7698 L/kg 1compartment NA NA Rat Human DTXSID4027319 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027319 TK.Half.Life NA 1.336 hours 1compartment NA NA Rat Human -DTXSID4027319 Css NA 0.1184 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027319 Css NA 0.394 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027319 Css NA 0.1029 mg/L PBTK NA 50% Rat Human -DTXSID4027319 Css NA 0.2709 mg/L PBTK NA 95% Rat Human -DTXSID4027361 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027361 Fup NA 0.5005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027361 Vd NA 1.218 L/kg 1compartment NA NA Human Human -DTXSID4027361 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4027361 TK.Half.Life NA 17.3 hours 1compartment NA NA Human Human -DTXSID4027361 Css NA 1.436 mg/L 3compartmentss NA 50% Human Human -DTXSID4027361 Css NA 7.902 mg/L 3compartmentss NA 95% Human Human -DTXSID4027361 Css NA 1.194 mg/L PBTK NA 50% Human Human -DTXSID4027361 Css NA 5.251 mg/L PBTK NA 95% Human Human -DTXSID4027361 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027361 Fup NA 0.5005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027361 Vd NA 1.082 L/kg 1compartment NA NA Rat Human +DTXSID4027319 TK.Half.Life NA 0.329 hours 1compartment NA NA Rat Human +DTXSID4027319 Css NA 0.00368 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027319 Css NA 0.03416 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027319 Css NA 0.003024 mg/L PBTK NA 50% Rat Human +DTXSID4027319 Css NA 0.02244 mg/L PBTK NA 95% Rat Human +DTXSID4027361 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027361 Fup 0.816 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027361 Vd NA 1.176 L/kg 1compartment NA NA Human Human +DTXSID4027361 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4027361 TK.Half.Life NA 9.72 hours 1compartment NA NA Human Human +DTXSID4027361 Css NA 0.8944 mg/L 3compartmentss NA 50% Human Human +DTXSID4027361 Css NA 5.679 mg/L 3compartmentss NA 95% Human Human +DTXSID4027361 Css NA 0.8026 mg/L PBTK NA 50% Human Human +DTXSID4027361 Css NA 3.718 mg/L PBTK NA 95% Human Human +DTXSID4027361 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027361 Fup 0.816 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027361 Vd NA 1.121 L/kg 1compartment NA NA Rat Human DTXSID4027361 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027361 TK.Half.Life NA 4.878 hours 1compartment NA NA Rat Human -DTXSID4027361 Css NA 0.3904 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027361 Css NA 1.828 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027361 Css NA 0.3135 mg/L PBTK NA 50% Rat Human -DTXSID4027361 Css NA 1.121 mg/L PBTK NA 95% Rat Human -DTXSID4027494 Clint NA 16.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027494 Fup NA 0.7776 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027494 Vd NA 0.9003 L/kg 1compartment NA NA Human Human +DTXSID4027361 TK.Half.Life NA 3.059 hours 1compartment NA NA Rat Human +DTXSID4027361 Css NA 0.05266 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027361 Css NA 0.328 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027361 Css NA 0.04769 mg/L PBTK NA 50% Rat Human +DTXSID4027361 Css NA 0.2094 mg/L PBTK NA 95% Rat Human +DTXSID4027494 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027494 Fup 0.642 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027494 Vd NA 0.7992 L/kg 1compartment NA NA Human Human DTXSID4027494 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027494 TK.Half.Life NA 0.7611 hours 1compartment NA NA Human Human -DTXSID4027494 Css NA 0.03825 mg/L 3compartmentss NA 50% Human Human -DTXSID4027494 Css NA 0.3633 mg/L 3compartmentss NA 95% Human Human -DTXSID4027494 Css NA 0.03191 mg/L PBTK NA 50% Human Human -DTXSID4027494 Css NA 0.2579 mg/L PBTK NA 95% Human Human -DTXSID4027494 Clint NA 16.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027494 Fup NA 0.7776 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027494 Vd NA 0.8943 L/kg 1compartment NA NA Rat Human +DTXSID4027494 TK.Half.Life NA 0.6948 hours 1compartment NA NA Human Human +DTXSID4027494 Css NA 0.03082 mg/L 3compartmentss NA 50% Human Human +DTXSID4027494 Css NA 0.3478 mg/L 3compartmentss NA 95% Human Human +DTXSID4027494 Css NA 0.02496 mg/L PBTK NA 50% Human Human +DTXSID4027494 Css NA 0.2337 mg/L PBTK NA 95% Human Human +DTXSID4027494 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027494 Fup 0.642 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027494 Vd NA 0.7929 L/kg 1compartment NA NA Rat Human DTXSID4027494 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027494 TK.Half.Life NA 0.3757 hours 1compartment NA NA Rat Human -DTXSID4027494 Css NA 0.01923 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027494 Css NA 0.1687 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027494 Css NA 0.0159 mg/L PBTK NA 50% Rat Human -DTXSID4027494 Css NA 0.1094 mg/L PBTK NA 95% Rat Human -DTXSID4027496 Clint NA 5.043 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027496 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027496 Vd NA 0.2744 L/kg 1compartment NA NA Human Human -DTXSID4027496 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027496 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human -DTXSID4027496 Css NA 4.07 mg/L 3compartmentss NA 50% Human Human -DTXSID4027496 Css NA 31.11 mg/L 3compartmentss NA 95% Human Human -DTXSID4027496 Css NA 2.442 mg/L PBTK NA 50% Human Human -DTXSID4027496 Css NA 18.28 mg/L PBTK NA 95% Human Human -DTXSID4027496 Clint NA 5.043 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027496 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027496 Vd NA 0.268 L/kg 1compartment NA NA Rat Human -DTXSID4027496 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027496 TK.Half.Life NA 3.749 hours 1compartment NA NA Rat Human -DTXSID4027496 Css NA 2.121 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027496 Css NA 12.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027496 Css NA 1.202 mg/L PBTK NA 50% Rat Human -DTXSID4027496 Css NA 7.07 mg/L PBTK NA 95% Rat Human -DTXSID4027498 Clint NA 0.5518 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027498 Fup NA 0.093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027498 Vd NA 1.142 L/kg 1compartment NA NA Human Human -DTXSID4027498 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID4027498 TK.Half.Life NA 46.83 hours 1compartment NA NA Human Human -DTXSID4027498 Css NA 6.105 mg/L 3compartmentss NA 50% Human Human -DTXSID4027498 Css NA 28.12 mg/L 3compartmentss NA 95% Human Human -DTXSID4027498 Css NA 3.967 mg/L PBTK NA 50% Human Human -DTXSID4027498 Css NA 16.88 mg/L PBTK NA 95% Human Human -DTXSID4027498 Clint NA 0.5518 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027498 Fup NA 0.093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027498 Vd NA 0.8902 L/kg 1compartment NA NA Rat Human -DTXSID4027498 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4027498 TK.Half.Life NA 14.73 hours 1compartment NA NA Rat Human -DTXSID4027498 Css NA 2.31 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027498 Css NA 8.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027498 Css NA 1.415 mg/L PBTK NA 50% Rat Human -DTXSID4027498 Css NA 5.016 mg/L PBTK NA 95% Rat Human -DTXSID4027521 Clint NA 8.268 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027521 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027521 Vd NA 2.015 L/kg 1compartment NA NA Human Human +DTXSID4027494 TK.Half.Life NA 0.3401 hours 1compartment NA NA Rat Human +DTXSID4027494 Css NA 0.00369 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027494 Css NA 0.03471 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027494 Css NA 0.003052 mg/L PBTK NA 50% Rat Human +DTXSID4027494 Css NA 0.02322 mg/L PBTK NA 95% Rat Human +DTXSID4027496 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027496 Fup 0.0638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027496 Vd NA 0.3529 L/kg 1compartment NA NA Human Human +DTXSID4027496 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4027496 TK.Half.Life NA 35.78 hours 1compartment NA NA Human Human +DTXSID4027496 Css NA 15.65 mg/L 3compartmentss NA 50% Human Human +DTXSID4027496 Css NA 71.87 mg/L 3compartmentss NA 95% Human Human +DTXSID4027496 Css NA 9.788 mg/L PBTK NA 50% Human Human +DTXSID4027496 Css NA 42.27 mg/L PBTK NA 95% Human Human +DTXSID4027496 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027496 Fup 0.0638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027496 Vd NA 0.3462 L/kg 1compartment NA NA Rat Human +DTXSID4027496 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4027496 TK.Half.Life NA 11.97 hours 1compartment NA NA Rat Human +DTXSID4027496 Css NA 1.026 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027496 Css NA 3.922 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027496 Css NA 0.6216 mg/L PBTK NA 50% Rat Human +DTXSID4027496 Css NA 2.245 mg/L PBTK NA 95% Rat Human +DTXSID4027498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027498 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027498 Vd NA 1.432 L/kg 1compartment NA NA Human Human +DTXSID4027498 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4027498 TK.Half.Life NA 3.032 hours 1compartment NA NA Human Human +DTXSID4027498 Css NA 0.185 mg/L 3compartmentss NA 50% Human Human +DTXSID4027498 Css NA 1.376 mg/L 3compartmentss NA 95% Human Human +DTXSID4027498 Css NA 0.1269 mg/L PBTK NA 50% Human Human +DTXSID4027498 Css NA 0.8944 mg/L PBTK NA 95% Human Human +DTXSID4027498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027498 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027498 Vd NA 1.122 L/kg 1compartment NA NA Rat Human +DTXSID4027498 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4027498 TK.Half.Life NA 1.209 hours 1compartment NA NA Rat Human +DTXSID4027498 Css NA 0.02377 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027498 Css NA 0.1457 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027498 Css NA 0.01611 mg/L PBTK NA 50% Rat Human +DTXSID4027498 Css NA 0.09114 mg/L PBTK NA 95% Rat Human +DTXSID4027521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027521 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027521 Vd NA 1.553 L/kg 1compartment NA NA Human Human DTXSID4027521 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027521 TK.Half.Life NA 4.744 hours 1compartment NA NA Human Human -DTXSID4027521 Css NA 0.198 mg/L 3compartmentss NA 50% Human Human -DTXSID4027521 Css NA 1.188 mg/L 3compartmentss NA 95% Human Human -DTXSID4027521 Css NA 0.157 mg/L PBTK NA 50% Human Human -DTXSID4027521 Css NA 0.8498 mg/L PBTK NA 95% Human Human -DTXSID4027521 Clint NA 8.268 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027521 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027521 Vd NA 1.598 L/kg 1compartment NA NA Rat Human +DTXSID4027521 TK.Half.Life NA 3.616 hours 1compartment NA NA Human Human +DTXSID4027521 Css NA 0.2158 mg/L 3compartmentss NA 50% Human Human +DTXSID4027521 Css NA 1.721 mg/L 3compartmentss NA 95% Human Human +DTXSID4027521 Css NA 0.1483 mg/L PBTK NA 50% Human Human +DTXSID4027521 Css NA 1.106 mg/L PBTK NA 95% Human Human +DTXSID4027521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027521 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027521 Vd NA 1.2 L/kg 1compartment NA NA Rat Human DTXSID4027521 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027521 TK.Half.Life NA 1.652 hours 1compartment NA NA Rat Human -DTXSID4027521 Css NA 0.1015 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027521 Css NA 0.4586 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027521 Css NA 0.07703 mg/L PBTK NA 50% Rat Human -DTXSID4027521 Css NA 0.3146 mg/L PBTK NA 95% Rat Human -DTXSID4027525 Clint NA 0.1736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027525 Fup NA 0.1972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027525 Vd NA 0.4442 L/kg 1compartment NA NA Human Human -DTXSID4027525 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4027525 TK.Half.Life NA 11.36 hours 1compartment NA NA Human Human -DTXSID4027525 Css NA 2.971 mg/L 3compartmentss NA 50% Human Human -DTXSID4027525 Css NA 11.38 mg/L 3compartmentss NA 95% Human Human -DTXSID4027525 Css NA 2.052 mg/L PBTK NA 50% Human Human -DTXSID4027525 Css NA 7.104 mg/L PBTK NA 95% Human Human -DTXSID4027525 Clint NA 0.1736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027525 Fup NA 0.1972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027525 Vd NA 0.4322 L/kg 1compartment NA NA Rat Human +DTXSID4027521 TK.Half.Life NA 1.387 hours 1compartment NA NA Rat Human +DTXSID4027521 Css NA 0.02836 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027521 Css NA 0.163 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027521 Css NA 0.01902 mg/L PBTK NA 50% Rat Human +DTXSID4027521 Css NA 0.1031 mg/L PBTK NA 95% Rat Human +DTXSID4027525 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027525 Fup 0.456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027525 Vd NA 0.3993 L/kg 1compartment NA NA Human Human +DTXSID4027525 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4027525 TK.Half.Life NA 5.663 hours 1compartment NA NA Human Human +DTXSID4027525 Css NA 1.631 mg/L 3compartmentss NA 50% Human Human +DTXSID4027525 Css NA 7.384 mg/L 3compartmentss NA 95% Human Human +DTXSID4027525 Css NA 1.154 mg/L PBTK NA 50% Human Human +DTXSID4027525 Css NA 4.599 mg/L PBTK NA 95% Human Human +DTXSID4027525 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027525 Fup 0.456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027525 Vd NA 0.4078 L/kg 1compartment NA NA Rat Human DTXSID4027525 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027525 TK.Half.Life NA 4.242 hours 1compartment NA NA Rat Human -DTXSID4027525 Css NA 0.9512 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027525 Css NA 2.977 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027525 Css NA 0.623 mg/L PBTK NA 50% Rat Human -DTXSID4027525 Css NA 1.731 mg/L PBTK NA 95% Rat Human +DTXSID4027525 TK.Half.Life NA 1.971 hours 1compartment NA NA Rat Human +DTXSID4027525 Css NA 0.1042 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027525 Css NA 0.3985 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027525 Css NA 0.07245 mg/L PBTK NA 50% Rat Human +DTXSID4027525 Css NA 0.2393 mg/L PBTK NA 95% Rat Human +DTXSID4027527 Clint NA 0.4913 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4027527 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4027527 Vd NA 19.85 L/kg 1compartment NA NA Human Human +DTXSID4027527 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID4027527 TK.Half.Life NA 25100 hours 1compartment NA NA Human Human +DTXSID4027527 Css NA 41.86 mg/L 3compartmentss NA 50% Human Human +DTXSID4027527 Css NA 242.1 mg/L 3compartmentss NA 95% Human Human +DTXSID4027527 Css NA 88.86 mg/L PBTK NA 50% Human Human +DTXSID4027527 Css NA 476.7 mg/L PBTK NA 95% Human Human +DTXSID4027527 Clint NA 0.4913 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4027527 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4027527 Vd NA 16.11 L/kg 1compartment NA NA Rat Human +DTXSID4027527 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID4027527 TK.Half.Life NA 3403 hours 1compartment NA NA Rat Human +DTXSID4027527 Css NA 1.395 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027527 Css NA 8.936 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027527 Css NA 3.117 mg/L PBTK NA 50% Rat Human +DTXSID4027527 Css NA 18.28 mg/L PBTK NA 95% Rat Human DTXSID4027529 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4027529 Fup NA 0.7324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027529 Vd NA 1.459 L/kg 1compartment NA NA Human Human +DTXSID4027529 Vd NA 1.109 L/kg 1compartment NA NA Human Human DTXSID4027529 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4027529 TK.Half.Life NA 14.74 hours 1compartment NA NA Human Human -DTXSID4027529 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human -DTXSID4027529 Css NA 6.778 mg/L 3compartmentss NA 95% Human Human -DTXSID4027529 Css NA 0.9206 mg/L PBTK NA 50% Human Human -DTXSID4027529 Css NA 4.561 mg/L PBTK NA 95% Human Human +DTXSID4027529 TK.Half.Life NA 10.26 hours 1compartment NA NA Human Human +DTXSID4027529 Css NA 0.9698 mg/L 3compartmentss NA 50% Human Human +DTXSID4027529 Css NA 6.649 mg/L 3compartmentss NA 95% Human Human +DTXSID4027529 Css NA 0.8508 mg/L PBTK NA 50% Human Human +DTXSID4027529 Css NA 4.325 mg/L PBTK NA 95% Human Human DTXSID4027529 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4027529 Fup NA 0.7324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027529 Vd NA 1.294 L/kg 1compartment NA NA Rat Human +DTXSID4027529 Vd NA 1.043 L/kg 1compartment NA NA Rat Human DTXSID4027529 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027529 TK.Half.Life NA 4.03 hours 1compartment NA NA Rat Human -DTXSID4027529 Css NA 0.268 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027529 Css NA 1.655 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027529 Css NA 0.2363 mg/L PBTK NA 50% Rat Human -DTXSID4027529 Css NA 1.024 mg/L PBTK NA 95% Rat Human +DTXSID4027529 TK.Half.Life NA 3.175 hours 1compartment NA NA Rat Human +DTXSID4027529 Css NA 0.05854 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027529 Css NA 0.3693 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027529 Css NA 0.05164 mg/L PBTK NA 50% Rat Human +DTXSID4027529 Css NA 0.2327 mg/L PBTK NA 95% Rat Human DTXSID4027577 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4027577 Fup NA 0.6025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027577 Vd NA 0.396 L/kg 1compartment NA NA Human Human +DTXSID4027577 Vd NA 0.3882 L/kg 1compartment NA NA Human Human DTXSID4027577 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027577 TK.Half.Life NA 4.252 hours 1compartment NA NA Human Human -DTXSID4027577 Css NA 1.372 mg/L 3compartmentss NA 50% Human Human -DTXSID4027577 Css NA 8.785 mg/L 3compartmentss NA 95% Human Human -DTXSID4027577 Css NA 0.9798 mg/L PBTK NA 50% Human Human -DTXSID4027577 Css NA 5.359 mg/L PBTK NA 95% Human Human +DTXSID4027577 TK.Half.Life NA 4.168 hours 1compartment NA NA Human Human +DTXSID4027577 Css NA 1.154 mg/L 3compartmentss NA 50% Human Human +DTXSID4027577 Css NA 7.535 mg/L 3compartmentss NA 95% Human Human +DTXSID4027577 Css NA 0.823 mg/L PBTK NA 50% Human Human +DTXSID4027577 Css NA 4.565 mg/L PBTK NA 95% Human Human DTXSID4027577 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4027577 Fup NA 0.6025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027577 Vd NA 0.4137 L/kg 1compartment NA NA Rat Human +DTXSID4027577 Vd NA 0.4071 L/kg 1compartment NA NA Rat Human DTXSID4027577 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027577 TK.Half.Life NA 1.514 hours 1compartment NA NA Rat Human -DTXSID4027577 Css NA 0.368 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027577 Css NA 2.129 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027577 Css NA 0.2494 mg/L PBTK NA 50% Rat Human -DTXSID4027577 Css NA 1.21 mg/L PBTK NA 95% Rat Human -DTXSID4027579 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027579 Fup NA 0.8129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027579 Vd NA 0.9669 L/kg 1compartment NA NA Human Human +DTXSID4027577 TK.Half.Life NA 1.49 hours 1compartment NA NA Rat Human +DTXSID4027577 Css NA 0.02248 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027577 Css NA 0.1694 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027577 Css NA 0.01536 mg/L PBTK NA 50% Rat Human +DTXSID4027577 Css NA 0.1022 mg/L PBTK NA 95% Rat Human +DTXSID4027579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027579 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027579 Vd NA 0.7665 L/kg 1compartment NA NA Human Human DTXSID4027579 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027579 TK.Half.Life NA 7.708 hours 1compartment NA NA Human Human -DTXSID4027579 Css NA 0.9461 mg/L 3compartmentss NA 50% Human Human -DTXSID4027579 Css NA 5.77 mg/L 3compartmentss NA 95% Human Human -DTXSID4027579 Css NA 0.8064 mg/L PBTK NA 50% Human Human -DTXSID4027579 Css NA 3.761 mg/L PBTK NA 95% Human Human -DTXSID4027579 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027579 Fup NA 0.8129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027579 Vd NA 0.9881 L/kg 1compartment NA NA Rat Human +DTXSID4027579 TK.Half.Life NA 7.231 hours 1compartment NA NA Human Human +DTXSID4027579 Css NA 1.065 mg/L 3compartmentss NA 50% Human Human +DTXSID4027579 Css NA 6.893 mg/L 3compartmentss NA 95% Human Human +DTXSID4027579 Css NA 0.8645 mg/L PBTK NA 50% Human Human +DTXSID4027579 Css NA 4.406 mg/L PBTK NA 95% Human Human +DTXSID4027579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027579 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027579 Vd NA 0.7933 L/kg 1compartment NA NA Rat Human DTXSID4027579 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027579 TK.Half.Life NA 2.68 hours 1compartment NA NA Rat Human -DTXSID4027579 Css NA 0.2408 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027579 Css NA 1.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027579 Css NA 0.2002 mg/L PBTK NA 50% Rat Human -DTXSID4027579 Css NA 0.8956 mg/L PBTK NA 95% Rat Human -DTXSID4027600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027600 Fup NA 0.3181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027600 Vd NA 0.3732 L/kg 1compartment NA NA Human Human +DTXSID4027579 TK.Half.Life NA 2.55 hours 1compartment NA NA Rat Human +DTXSID4027579 Css NA 0.06402 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027579 Css NA 0.4067 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027579 Css NA 0.05193 mg/L PBTK NA 50% Rat Human +DTXSID4027579 Css NA 0.249 mg/L PBTK NA 95% Rat Human +DTXSID4027600 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027600 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027600 Vd NA 0.2755 L/kg 1compartment NA NA Human Human DTXSID4027600 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027600 TK.Half.Life NA 7.599 hours 1compartment NA NA Human Human -DTXSID4027600 Css NA 2.503 mg/L 3compartmentss NA 50% Human Human -DTXSID4027600 Css NA 9.584 mg/L 3compartmentss NA 95% Human Human -DTXSID4027600 Css NA 1.682 mg/L PBTK NA 50% Human Human -DTXSID4027600 Css NA 5.883 mg/L PBTK NA 95% Human Human -DTXSID4027600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027600 Fup NA 0.3181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027600 Vd NA 0.3733 L/kg 1compartment NA NA Rat Human +DTXSID4027600 TK.Half.Life NA 6.022 hours 1compartment NA NA Human Human +DTXSID4027600 Css NA 1.476 mg/L 3compartmentss NA 50% Human Human +DTXSID4027600 Css NA 6.031 mg/L 3compartmentss NA 95% Human Human +DTXSID4027600 Css NA 0.9536 mg/L PBTK NA 50% Human Human +DTXSID4027600 Css NA 3.611 mg/L PBTK NA 95% Human Human +DTXSID4027600 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027600 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027600 Vd NA 0.2886 L/kg 1compartment NA NA Rat Human DTXSID4027600 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027600 TK.Half.Life NA 2.588 hours 1compartment NA NA Rat Human -DTXSID4027600 Css NA 0.6894 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027600 Css NA 2.252 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027600 Css NA 0.4393 mg/L PBTK NA 50% Rat Human -DTXSID4027600 Css NA 1.291 mg/L PBTK NA 95% Rat Human +DTXSID4027600 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human +DTXSID4027600 Css NA 0.008144 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027600 Css NA 0.03295 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027600 Css NA 0.004954 mg/L PBTK NA 50% Rat Human +DTXSID4027600 Css NA 0.01896 mg/L PBTK NA 95% Rat Human DTXSID4027604 Clint 2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4027604 Fup 0.00517 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4027604 Vd NA 0.1798 L/kg 1compartment NA NA Human Human +DTXSID4027604 Vd NA 0.1807 L/kg 1compartment NA NA Human Human DTXSID4027604 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID4027604 TK.Half.Life NA 51.8 hours 1compartment NA NA Human Human -DTXSID4027604 Css NA 33.08 mg/L 3compartmentss NA 50% Human Human -DTXSID4027604 Css NA 162.9 mg/L 3compartmentss NA 95% Human Human -DTXSID4027604 Css NA 19.44 mg/L PBTK NA 50% Human Human -DTXSID4027604 Css NA 94.1 mg/L PBTK NA 95% Human Human +DTXSID4027604 TK.Half.Life NA 52 hours 1compartment NA NA Human Human +DTXSID4027604 Css NA 31.86 mg/L 3compartmentss NA 50% Human Human +DTXSID4027604 Css NA 155.9 mg/L 3compartmentss NA 95% Human Human +DTXSID4027604 Css NA 18.67 mg/L PBTK NA 50% Human Human +DTXSID4027604 Css NA 89.77 mg/L PBTK NA 95% Human Human DTXSID4027604 Clint 2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4027604 Fup 0.00517 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4027604 Vd NA 0.1745 L/kg 1compartment NA NA Rat Human +DTXSID4027604 Vd NA 0.1752 L/kg 1compartment NA NA Rat Human DTXSID4027604 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID4027604 TK.Half.Life NA 28.36 hours 1compartment NA NA Rat Human -DTXSID4027604 Css NA 15.45 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027604 Css NA 57.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027604 Css NA 8.433 mg/L PBTK NA 50% Rat Human -DTXSID4027604 Css NA 31.36 mg/L PBTK NA 95% Rat Human -DTXSID4027608 Clint NA 25.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027608 Fup NA 0.0875 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027608 Vd NA 2.104 L/kg 1compartment NA NA Human Human -DTXSID4027608 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027608 TK.Half.Life NA 7.052 hours 1compartment NA NA Human Human -DTXSID4027608 Css NA 0.3876 mg/L 3compartmentss NA 50% Human Human -DTXSID4027608 Css NA 2.707 mg/L 3compartmentss NA 95% Human Human -DTXSID4027608 Css NA 0.2606 mg/L PBTK NA 50% Human Human -DTXSID4027608 Css NA 1.734 mg/L PBTK NA 95% Human Human -DTXSID4027608 Clint NA 25.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027608 Fup NA 0.0875 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027608 Vd NA 1.589 L/kg 1compartment NA NA Rat Human +DTXSID4027604 TK.Half.Life NA 28.45 hours 1compartment NA NA Rat Human +DTXSID4027604 Css NA 3.51 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027604 Css NA 13.07 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027604 Css NA 1.983 mg/L PBTK NA 50% Rat Human +DTXSID4027604 Css NA 7.334 mg/L PBTK NA 95% Rat Human +DTXSID4027608 Clint 4.1 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID4027608 Fup 0.0851 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027608 Vd NA 2.085 L/kg 1compartment NA NA Human Human +DTXSID4027608 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4027608 TK.Half.Life NA 32.47 hours 1compartment NA NA Human Human +DTXSID4027608 Css NA 2.141 mg/L 3compartmentss NA 50% Human Human +DTXSID4027608 Css NA 11.9 mg/L 3compartmentss NA 95% Human Human +DTXSID4027608 Css NA 1.437 mg/L PBTK NA 50% Human Human +DTXSID4027608 Css NA 7.594 mg/L PBTK NA 95% Human Human +DTXSID4027608 Clint 4.1 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human +DTXSID4027608 Fup 0.0851 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027608 Vd NA 1.574 L/kg 1compartment NA NA Rat Human DTXSID4027608 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027608 TK.Half.Life NA 2.249 hours 1compartment NA NA Rat Human -DTXSID4027608 Css NA 0.212 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027608 Css NA 1.182 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027608 Css NA 0.1352 mg/L PBTK NA 50% Rat Human -DTXSID4027608 Css NA 0.7303 mg/L PBTK NA 95% Rat Human +DTXSID4027608 TK.Half.Life NA 3.842 hours 1compartment NA NA Rat Human +DTXSID4027608 Css NA 0.09336 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027608 Css NA 0.4845 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027608 Css NA 0.06134 mg/L PBTK NA 50% Rat Human +DTXSID4027608 Css NA 0.3065 mg/L PBTK NA 95% Rat Human DTXSID4027652 Clint NA 0.007305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4027652 Fup NA 0.3914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027652 Vd NA 0.4229 L/kg 1compartment NA NA Human Human +DTXSID4027652 Vd NA 0.4206 L/kg 1compartment NA NA Human Human DTXSID4027652 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027652 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human -DTXSID4027652 Css NA 1.879 mg/L 3compartmentss NA 50% Human Human -DTXSID4027652 Css NA 8.257 mg/L 3compartmentss NA 95% Human Human -DTXSID4027652 Css NA 1.346 mg/L PBTK NA 50% Human Human -DTXSID4027652 Css NA 5.212 mg/L PBTK NA 95% Human Human +DTXSID4027652 TK.Half.Life NA 6.863 hours 1compartment NA NA Human Human +DTXSID4027652 Css NA 1.588 mg/L 3compartmentss NA 50% Human Human +DTXSID4027652 Css NA 7.141 mg/L 3compartmentss NA 95% Human Human +DTXSID4027652 Css NA 1.13 mg/L PBTK NA 50% Human Human +DTXSID4027652 Css NA 4.453 mg/L PBTK NA 95% Human Human DTXSID4027652 Clint NA 0.007305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4027652 Fup NA 0.3914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027652 Vd NA 0.4323 L/kg 1compartment NA NA Rat Human +DTXSID4027652 Vd NA 0.4297 L/kg 1compartment NA NA Rat Human DTXSID4027652 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027652 TK.Half.Life NA 2.42 hours 1compartment NA NA Rat Human -DTXSID4027652 Css NA 0.5266 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027652 Css NA 1.908 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027652 Css NA 0.3558 mg/L PBTK NA 50% Rat Human -DTXSID4027652 Css NA 1.113 mg/L PBTK NA 95% Rat Human -DTXSID4027656 Clint NA 5.125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027656 Fup NA 0.1236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027656 Vd NA 2.615 L/kg 1compartment NA NA Human Human -DTXSID4027656 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4027656 TK.Half.Life NA 38.21 hours 1compartment NA NA Human Human -DTXSID4027656 Css NA 1.868 mg/L 3compartmentss NA 50% Human Human -DTXSID4027656 Css NA 10.01 mg/L 3compartmentss NA 95% Human Human -DTXSID4027656 Css NA 1.297 mg/L PBTK NA 50% Human Human -DTXSID4027656 Css NA 6.701 mg/L PBTK NA 95% Human Human -DTXSID4027656 Clint NA 5.125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027656 Fup NA 0.1236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027656 Vd NA 1.972 L/kg 1compartment NA NA Rat Human -DTXSID4027656 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4027656 TK.Half.Life NA 8.469 hours 1compartment NA NA Rat Human -DTXSID4027656 Css NA 0.977 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027656 Css NA 3.764 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027656 Css NA 0.65 mg/L PBTK NA 50% Rat Human -DTXSID4027656 Css NA 2.38 mg/L PBTK NA 95% Rat Human -DTXSID4027789 Clint NA 0.1238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027789 Fup NA 0.739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027789 Vd NA 1.832 L/kg 1compartment NA NA Human Human -DTXSID4027789 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4027789 TK.Half.Life NA 13.37 hours 1compartment NA NA Human Human -DTXSID4027789 Css NA 0.7173 mg/L 3compartmentss NA 50% Human Human -DTXSID4027789 Css NA 5.044 mg/L 3compartmentss NA 95% Human Human -DTXSID4027789 Css NA 0.7014 mg/L PBTK NA 50% Human Human -DTXSID4027789 Css NA 3.476 mg/L PBTK NA 95% Human Human -DTXSID4027789 Clint NA 0.1238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027789 Fup NA 0.739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027789 Vd NA 1.856 L/kg 1compartment NA NA Rat Human +DTXSID4027652 TK.Half.Life NA 2.406 hours 1compartment NA NA Rat Human +DTXSID4027652 Css NA 0.02932 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027652 Css NA 0.1853 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027652 Css NA 0.02005 mg/L PBTK NA 50% Rat Human +DTXSID4027652 Css NA 0.115 mg/L PBTK NA 95% Rat Human +DTXSID4027656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027656 Fup 0.0446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027656 Vd NA 2.999 L/kg 1compartment NA NA Human Human +DTXSID4027656 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4027656 TK.Half.Life NA 44.72 hours 1compartment NA NA Human Human +DTXSID4027656 Css NA 1.781 mg/L 3compartmentss NA 50% Human Human +DTXSID4027656 Css NA 11.91 mg/L 3compartmentss NA 95% Human Human +DTXSID4027656 Css NA 1.231 mg/L PBTK NA 50% Human Human +DTXSID4027656 Css NA 7.92 mg/L PBTK NA 95% Human Human +DTXSID4027656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027656 Fup 0.0446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027656 Vd NA 2.248 L/kg 1compartment NA NA Rat Human +DTXSID4027656 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4027656 TK.Half.Life NA 7.241 hours 1compartment NA NA Rat Human +DTXSID4027656 Css NA 0.2302 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027656 Css NA 1.243 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027656 Css NA 0.1572 mg/L PBTK NA 50% Rat Human +DTXSID4027656 Css NA 0.833 mg/L PBTK NA 95% Rat Human +DTXSID4027658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027658 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027658 Vd NA 2.864 L/kg 1compartment NA NA Human Human +DTXSID4027658 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4027658 TK.Half.Life NA 18.73 hours 1compartment NA NA Human Human +DTXSID4027658 Css NA 0.7322 mg/L 3compartmentss NA 50% Human Human +DTXSID4027658 Css NA 4.669 mg/L 3compartmentss NA 95% Human Human +DTXSID4027658 Css NA 0.5092 mg/L PBTK NA 50% Human Human +DTXSID4027658 Css NA 3.174 mg/L PBTK NA 95% Human Human +DTXSID4027658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027658 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027658 Vd NA 2.153 L/kg 1compartment NA NA Rat Human +DTXSID4027658 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4027658 TK.Half.Life NA 3.721 hours 1compartment NA NA Rat Human +DTXSID4027658 Css NA 0.09446 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027658 Css NA 0.5002 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027658 Css NA 0.06494 mg/L PBTK NA 50% Rat Human +DTXSID4027658 Css NA 0.3312 mg/L PBTK NA 95% Rat Human +DTXSID4027781 Clint 4.951 NA uL/min/million hepatocytes NA Pradeep 2020 NA Human Human +DTXSID4027781 Fup 0.01176 NA NA Pradeep 2020 NA Human Human +DTXSID4027781 Vd NA 0.169 L/kg 1compartment NA NA Human Human +DTXSID4027781 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4027781 TK.Half.Life NA 2.197 hours 1compartment NA NA Human Human +DTXSID4027781 Css NA 1.992 mg/L 3compartmentss NA 50% Human Human +DTXSID4027781 Css NA 20.71 mg/L 3compartmentss NA 95% Human Human +DTXSID4027781 Css NA 1.158 mg/L PBTK NA 50% Human Human +DTXSID4027781 Css NA 12.01 mg/L PBTK NA 95% Human Human +DTXSID4027781 Clint 4.951 NA uL/min/million hepatocytes NA Pradeep 2020 NA Rat Human +DTXSID4027781 Fup 0.01176 NA NA Pradeep 2020 NA Rat Human +DTXSID4027781 Vd NA 0.1687 L/kg 1compartment NA NA Rat Human +DTXSID4027781 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4027781 TK.Half.Life NA 1.462 hours 1compartment NA NA Rat Human +DTXSID4027781 Css NA 0.07686 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027781 Css NA 0.8839 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027781 Css NA 0.04218 mg/L PBTK NA 50% Rat Human +DTXSID4027781 Css NA 0.4889 mg/L PBTK NA 95% Rat Human +DTXSID4027789 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027789 Fup 0.628 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027789 Vd NA 0.7143 L/kg 1compartment NA NA Human Human +DTXSID4027789 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4027789 TK.Half.Life NA 7.4 hours 1compartment NA NA Human Human +DTXSID4027789 Css NA 1.152 mg/L 3compartmentss NA 50% Human Human +DTXSID4027789 Css NA 7.856 mg/L 3compartmentss NA 95% Human Human +DTXSID4027789 Css NA 0.9278 mg/L PBTK NA 50% Human Human +DTXSID4027789 Css NA 4.922 mg/L PBTK NA 95% Human Human +DTXSID4027789 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027789 Fup 0.628 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027789 Vd NA 0.7182 L/kg 1compartment NA NA Rat Human DTXSID4027789 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027789 TK.Half.Life NA 5.045 hours 1compartment NA NA Rat Human -DTXSID4027789 Css NA 0.2001 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027789 Css NA 1.451 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027789 Css NA 0.1925 mg/L PBTK NA 50% Rat Human -DTXSID4027789 Css NA 0.9174 mg/L PBTK NA 95% Rat Human -DTXSID4027866 Clint NA 1.489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027866 Fup NA 0.1104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027866 Vd NA 2.958 L/kg 1compartment NA NA Human Human -DTXSID4027866 Days.Css NA 58 Days PBTK NA NA Human Human -DTXSID4027866 TK.Half.Life NA 270.3 hours 1compartment NA NA Human Human -DTXSID4027866 Css NA 11.37 mg/L 3compartmentss NA 50% Human Human -DTXSID4027866 Css NA 48.74 mg/L 3compartmentss NA 95% Human Human -DTXSID4027866 Css NA 7.979 mg/L PBTK NA 50% Human Human -DTXSID4027866 Css NA 32.23 mg/L PBTK NA 95% Human Human -DTXSID4027866 Clint NA 1.489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027866 Fup NA 0.1104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027866 Vd NA 2.223 L/kg 1compartment NA NA Rat Human -DTXSID4027866 Days.Css NA 27 Days PBTK NA NA Rat Human -DTXSID4027866 TK.Half.Life NA 38.68 hours 1compartment NA NA Rat Human -DTXSID4027866 Css NA 5.531 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027866 Css NA 15.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027866 Css NA 3.696 mg/L PBTK NA 50% Rat Human -DTXSID4027866 Css NA 9.954 mg/L PBTK NA 95% Rat Human -DTXSID4027868 Clint NA 9.506 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027868 Fup NA 0.1134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027868 Vd NA 3.109 L/kg 1compartment NA NA Human Human -DTXSID4027868 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID4027868 TK.Half.Life NA 117.6 hours 1compartment NA NA Human Human -DTXSID4027868 Css NA 4.59 mg/L 3compartmentss NA 50% Human Human -DTXSID4027868 Css NA 28.32 mg/L 3compartmentss NA 95% Human Human -DTXSID4027868 Css NA 3.21 mg/L PBTK NA 50% Human Human -DTXSID4027868 Css NA 19.16 mg/L PBTK NA 95% Human Human -DTXSID4027868 Clint NA 9.506 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027868 Fup NA 0.1134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027868 Vd NA 2.332 L/kg 1compartment NA NA Rat Human -DTXSID4027868 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID4027868 TK.Half.Life NA 15.89 hours 1compartment NA NA Rat Human -DTXSID4027868 Css NA 2.548 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027868 Css NA 12.51 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027868 Css NA 1.705 mg/L PBTK NA 50% Rat Human -DTXSID4027868 Css NA 8.047 mg/L PBTK NA 95% Rat Human -DTXSID4027991 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027991 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027991 Vd NA 8.354 L/kg 1compartment NA NA Human Human -DTXSID4027991 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4027991 TK.Half.Life NA 398400 hours 1compartment NA NA Human Human -DTXSID4027991 Css NA 3457 mg/L 3compartmentss NA 50% Human Human -DTXSID4027991 Css NA 8217 mg/L 3compartmentss NA 95% Human Human -DTXSID4027991 Css NA 3674 mg/L PBTK NA 50% Human Human -DTXSID4027991 Css NA 7966 mg/L PBTK NA 95% Human Human -DTXSID4027991 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027991 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027991 Vd NA 6.523 L/kg 1compartment NA NA Rat Human -DTXSID4027991 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID4027991 TK.Half.Life NA 26000 hours 1compartment NA NA Rat Human -DTXSID4027991 Css NA 928.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027991 Css NA 1432 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027991 Css NA 983.6 mg/L PBTK NA 50% Rat Human -DTXSID4027991 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID4027997 Clint NA 2.531 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027997 Fup NA 0.3076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4027997 Vd NA 1.124 L/kg 1compartment NA NA Human Human +DTXSID4027789 TK.Half.Life NA 2.524 hours 1compartment NA NA Rat Human +DTXSID4027789 Css NA 0.06976 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027789 Css NA 0.4507 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027789 Css NA 0.05583 mg/L PBTK NA 50% Rat Human +DTXSID4027789 Css NA 0.2742 mg/L PBTK NA 95% Rat Human +DTXSID4027997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027997 Fup 0.393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4027997 Vd NA 1.284 L/kg 1compartment NA NA Human Human DTXSID4027997 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4027997 TK.Half.Life NA 5.458 hours 1compartment NA NA Human Human -DTXSID4027997 Css NA 0.5022 mg/L 3compartmentss NA 50% Human Human -DTXSID4027997 Css NA 2.529 mg/L 3compartmentss NA 95% Human Human -DTXSID4027997 Css NA 0.3775 mg/L PBTK NA 50% Human Human -DTXSID4027997 Css NA 1.688 mg/L PBTK NA 95% Human Human -DTXSID4027997 Clint NA 2.531 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027997 Fup NA 0.3076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4027997 Vd NA 0.9489 L/kg 1compartment NA NA Rat Human +DTXSID4027997 TK.Half.Life NA 1.464 hours 1compartment NA NA Human Human +DTXSID4027997 Css NA 0.05192 mg/L 3compartmentss NA 50% Human Human +DTXSID4027997 Css NA 0.4157 mg/L 3compartmentss NA 95% Human Human +DTXSID4027997 Css NA 0.04081 mg/L PBTK NA 50% Human Human +DTXSID4027997 Css NA 0.2956 mg/L PBTK NA 95% Human Human +DTXSID4027997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027997 Fup 0.393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4027997 Vd NA 1.087 L/kg 1compartment NA NA Rat Human DTXSID4027997 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4027997 TK.Half.Life NA 2.371 hours 1compartment NA NA Rat Human -DTXSID4027997 Css NA 0.2322 mg/L 3compartmentss NA 50% Rat Human -DTXSID4027997 Css NA 0.9108 mg/L 3compartmentss NA 95% Rat Human -DTXSID4027997 Css NA 0.1677 mg/L PBTK NA 50% Rat Human -DTXSID4027997 Css NA 0.5603 mg/L PBTK NA 95% Rat Human -DTXSID4028040 Clint NA 13.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4028040 Fup NA 0.0603 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4028040 Vd NA 2.42 L/kg 1compartment NA NA Human Human -DTXSID4028040 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4028040 TK.Half.Life NA 21.49 hours 1compartment NA NA Human Human -DTXSID4028040 Css NA 1.195 mg/L 3compartmentss NA 50% Human Human -DTXSID4028040 Css NA 7.271 mg/L 3compartmentss NA 95% Human Human -DTXSID4028040 Css NA 0.8054 mg/L PBTK NA 50% Human Human -DTXSID4028040 Css NA 4.677 mg/L PBTK NA 95% Human Human -DTXSID4028040 Clint NA 13.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4028040 Fup NA 0.0603 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4028040 Vd NA 1.818 L/kg 1compartment NA NA Rat Human -DTXSID4028040 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4028040 TK.Half.Life NA 5.668 hours 1compartment NA NA Rat Human -DTXSID4028040 Css NA 0.6522 mg/L 3compartmentss NA 50% Rat Human -DTXSID4028040 Css NA 3.356 mg/L 3compartmentss NA 95% Rat Human -DTXSID4028040 Css NA 0.417 mg/L PBTK NA 50% Rat Human -DTXSID4028040 Css NA 2.059 mg/L PBTK NA 95% Rat Human -DTXSID4028460 Clint NA 136.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4028460 Fup NA 0.3621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4028460 Vd NA 2.024 L/kg 1compartment NA NA Human Human -DTXSID4028460 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4028460 TK.Half.Life NA 1.639 hours 1compartment NA NA Human Human -DTXSID4028460 Css NA 0.01366 mg/L 3compartmentss NA 50% Human Human -DTXSID4028460 Css NA 0.1001 mg/L 3compartmentss NA 95% Human Human -DTXSID4028460 Css NA 0.0106 mg/L PBTK NA 50% Human Human -DTXSID4028460 Css NA 0.07033 mg/L PBTK NA 95% Human Human -DTXSID4028460 Clint NA 136.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4028460 Fup NA 0.3621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4028460 Vd NA 1.6 L/kg 1compartment NA NA Rat Human -DTXSID4028460 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4028460 TK.Half.Life NA 0.5635 hours 1compartment NA NA Rat Human -DTXSID4028460 Css NA 0.007377 mg/L 3compartmentss NA 50% Rat Human -DTXSID4028460 Css NA 0.04461 mg/L 3compartmentss NA 95% Rat Human -DTXSID4028460 Css NA 0.005572 mg/L PBTK NA 50% Rat Human -DTXSID4028460 Css NA 0.0319 mg/L PBTK NA 95% Rat Human -DTXSID4028880 Clint NA 558.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4028880 Fup NA 0.0025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4028880 Vd NA 70.76 L/kg 1compartment NA NA Human Human -DTXSID4028880 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID4028880 TK.Half.Life NA 89.08 hours 1compartment NA NA Human Human -DTXSID4028880 Css NA 0.01236 mg/L 3compartmentss NA 50% Human Human -DTXSID4028880 Css NA 0.07497 mg/L 3compartmentss NA 95% Human Human -DTXSID4028880 Css NA 0.1003 mg/L PBTK NA 50% Human Human -DTXSID4028880 Css NA 0.5582 mg/L PBTK NA 95% Human Human -DTXSID4028880 Clint NA 558.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4028880 Fup NA 0.0025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4028880 Vd NA 60.43 L/kg 1compartment NA NA Rat Human -DTXSID4028880 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID4028880 TK.Half.Life NA 15.8 hours 1compartment NA NA Rat Human -DTXSID4028880 Css NA 0.006346 mg/L 3compartmentss NA 50% Rat Human -DTXSID4028880 Css NA 0.02673 mg/L 3compartmentss NA 95% Rat Human -DTXSID4028880 Css NA 0.05405 mg/L PBTK NA 50% Rat Human -DTXSID4028880 Css NA 0.2341 mg/L PBTK NA 95% Rat Human -DTXSID4029062 Clint NA 381.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029062 Fup NA 0.495 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029062 Vd NA 1.11 L/kg 1compartment NA NA Human Human -DTXSID4029062 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4029062 TK.Half.Life NA 0.7434 hours 1compartment NA NA Human Human -DTXSID4029062 Css NA 0.002427 mg/L 3compartmentss NA 50% Human Human -DTXSID4029062 Css NA 0.02393 mg/L 3compartmentss NA 95% Human Human -DTXSID4029062 Css NA 0.001965 mg/L PBTK NA 50% Human Human -DTXSID4029062 Css NA 0.01703 mg/L PBTK NA 95% Human Human -DTXSID4029062 Clint NA 381.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029062 Fup NA 0.495 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029062 Vd NA 0.99 L/kg 1compartment NA NA Rat Human -DTXSID4029062 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4029062 TK.Half.Life NA 0.29 hours 1compartment NA NA Rat Human -DTXSID4029062 Css NA 0.001297 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029062 Css NA 0.01097 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029062 Css NA 0.001028 mg/L PBTK NA 50% Rat Human -DTXSID4029062 Css NA 0.007414 mg/L PBTK NA 95% Rat Human -DTXSID4029145 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029145 Fup NA 0.9784 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029145 Vd NA 0.9207 L/kg 1compartment NA NA Human Human +DTXSID4027997 TK.Half.Life NA 0.6167 hours 1compartment NA NA Rat Human +DTXSID4027997 Css NA 0.006454 mg/L 3compartmentss NA 50% Rat Human +DTXSID4027997 Css NA 0.03847 mg/L 3compartmentss NA 95% Rat Human +DTXSID4027997 Css NA 0.005098 mg/L PBTK NA 50% Rat Human +DTXSID4027997 Css NA 0.02703 mg/L PBTK NA 95% Rat Human +DTXSID4028040 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4028040 Fup 0.0555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4028040 Vd NA 2.554 L/kg 1compartment NA NA Human Human +DTXSID4028040 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4028040 TK.Half.Life NA 17.61 hours 1compartment NA NA Human Human +DTXSID4028040 Css NA 0.8513 mg/L 3compartmentss NA 50% Human Human +DTXSID4028040 Css NA 5.627 mg/L 3compartmentss NA 95% Human Human +DTXSID4028040 Css NA 0.575 mg/L PBTK NA 50% Human Human +DTXSID4028040 Css NA 3.659 mg/L PBTK NA 95% Human Human +DTXSID4028040 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4028040 Fup 0.0555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4028040 Vd NA 1.917 L/kg 1compartment NA NA Rat Human +DTXSID4028040 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4028040 TK.Half.Life NA 4.351 hours 1compartment NA NA Rat Human +DTXSID4028040 Css NA 0.1095 mg/L 3compartmentss NA 50% Rat Human +DTXSID4028040 Css NA 0.5934 mg/L 3compartmentss NA 95% Rat Human +DTXSID4028040 Css NA 0.07291 mg/L PBTK NA 50% Rat Human +DTXSID4028040 Css NA 0.3815 mg/L PBTK NA 95% Rat Human +DTXSID40284160 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40284160 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40284160 Vd NA 0.7122 L/kg 1compartment NA NA Human Human +DTXSID40284160 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40284160 TK.Half.Life NA 1.729 hours 1compartment NA NA Human Human +DTXSID40284160 Css NA 0.2053 mg/L 3compartmentss NA 50% Human Human +DTXSID40284160 Css NA 1.307 mg/L 3compartmentss NA 95% Human Human +DTXSID40284160 Css NA 0.1497 mg/L PBTK NA 50% Human Human +DTXSID40284160 Css NA 0.8627 mg/L PBTK NA 95% Human Human +DTXSID40284160 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40284160 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40284160 Vd NA 0.659 L/kg 1compartment NA NA Rat Human +DTXSID40284160 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40284160 TK.Half.Life NA 0.8998 hours 1compartment NA NA Rat Human +DTXSID40284160 Css NA 0.02449 mg/L 3compartmentss NA 50% Rat Human +DTXSID40284160 Css NA 0.1148 mg/L 3compartmentss NA 95% Rat Human +DTXSID40284160 Css NA 0.01771 mg/L PBTK NA 50% Rat Human +DTXSID40284160 Css NA 0.07352 mg/L PBTK NA 95% Rat Human +DTXSID4029145 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029145 Fup 0.819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029145 Vd NA 0.8264 L/kg 1compartment NA NA Human Human DTXSID4029145 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4029145 TK.Half.Life NA 6.123 hours 1compartment NA NA Human Human -DTXSID4029145 Css NA 0.8076 mg/L 3compartmentss NA 50% Human Human -DTXSID4029145 Css NA 2.752 mg/L 3compartmentss NA 95% Human Human -DTXSID4029145 Css NA 0.7029 mg/L PBTK NA 50% Human Human -DTXSID4029145 Css NA 1.989 mg/L PBTK NA 95% Human Human -DTXSID4029145 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029145 Fup NA 0.9784 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029145 Vd NA 0.935 L/kg 1compartment NA NA Rat Human +DTXSID4029145 TK.Half.Life NA 0.6336 hours 1compartment NA NA Human Human +DTXSID4029145 Css NA 0.02006 mg/L 3compartmentss NA 50% Human Human +DTXSID4029145 Css NA 0.242 mg/L 3compartmentss NA 95% Human Human +DTXSID4029145 Css NA 0.01657 mg/L PBTK NA 50% Human Human +DTXSID4029145 Css NA 0.168 mg/L PBTK NA 95% Human Human +DTXSID4029145 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029145 Fup 0.819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029145 Vd NA 0.8384 L/kg 1compartment NA NA Rat Human DTXSID4029145 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4029145 TK.Half.Life NA 2.111 hours 1compartment NA NA Rat Human -DTXSID4029145 Css NA 0.2051 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029145 Css NA 0.6295 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029145 Css NA 0.1758 mg/L PBTK NA 50% Rat Human -DTXSID4029145 Css NA 0.4229 mg/L PBTK NA 95% Rat Human -DTXSID4029149 Clint NA 0.501 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029149 Fup NA 0.012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029149 Vd NA 30.84 L/kg 1compartment NA NA Human Human -DTXSID4029149 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4029149 TK.Half.Life NA 38360 hours 1compartment NA NA Human Human -DTXSID4029149 Css NA 31.24 mg/L 3compartmentss NA 50% Human Human -DTXSID4029149 Css NA 168.8 mg/L 3compartmentss NA 95% Human Human -DTXSID4029149 Css NA 102.6 mg/L PBTK NA 50% Human Human -DTXSID4029149 Css NA 515.2 mg/L PBTK NA 95% Human Human -DTXSID4029149 Clint NA 0.501 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029149 Fup NA 0.012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029149 Vd NA 25.49 L/kg 1compartment NA NA Rat Human -DTXSID4029149 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID4029149 TK.Half.Life NA 5357 hours 1compartment NA NA Rat Human -DTXSID4029149 Css NA 15.92 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029149 Css NA 58.51 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029149 Css NA 54.54 mg/L PBTK NA 50% Rat Human -DTXSID4029149 Css NA 194.8 mg/L PBTK NA 95% Rat Human -DTXSID4029195 Clint NA 3.038 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029195 Fup NA 0.715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029195 Vd NA 2.144 L/kg 1compartment NA NA Human Human -DTXSID4029195 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4029195 TK.Half.Life NA 3.838 hours 1compartment NA NA Human Human -DTXSID4029195 Css NA 0.1404 mg/L 3compartmentss NA 50% Human Human -DTXSID4029195 Css NA 1.266 mg/L 3compartmentss NA 95% Human Human -DTXSID4029195 Css NA 0.1478 mg/L PBTK NA 50% Human Human -DTXSID4029195 Css NA 0.945 mg/L PBTK NA 95% Human Human -DTXSID4029195 Clint NA 3.038 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029195 Fup NA 0.715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029195 Vd NA 2.12 L/kg 1compartment NA NA Rat Human +DTXSID4029145 TK.Half.Life NA 0.311 hours 1compartment NA NA Rat Human +DTXSID4029145 Css NA 0.0007165 mg/L 3compartmentss NA 50% Rat Human +DTXSID4029145 Css NA 0.009293 mg/L 3compartmentss NA 95% Rat Human +DTXSID4029145 Css NA 0.0005902 mg/L PBTK NA 50% Rat Human +DTXSID4029145 Css NA 0.006414 mg/L PBTK NA 95% Rat Human +DTXSID4029195 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029195 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029195 Vd NA 1.692 L/kg 1compartment NA NA Human Human +DTXSID4029195 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4029195 TK.Half.Life NA 18.37 hours 1compartment NA NA Human Human +DTXSID4029195 Css NA 0.8534 mg/L 3compartmentss NA 50% Human Human +DTXSID4029195 Css NA 7.146 mg/L 3compartmentss NA 95% Human Human +DTXSID4029195 Css NA 0.8364 mg/L PBTK NA 50% Human Human +DTXSID4029195 Css NA 4.772 mg/L PBTK NA 95% Human Human +DTXSID4029195 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029195 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029195 Vd NA 1.669 L/kg 1compartment NA NA Rat Human DTXSID4029195 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4029195 TK.Half.Life NA 2.081 hours 1compartment NA NA Rat Human -DTXSID4029195 Css NA 0.06097 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029195 Css NA 0.5174 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029195 Css NA 0.06544 mg/L PBTK NA 50% Rat Human -DTXSID4029195 Css NA 0.3465 mg/L PBTK NA 95% Rat Human -DTXSID4029220 Clint NA 3.066 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029220 Fup NA 0.9489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029220 Vd NA 2.468 L/kg 1compartment NA NA Human Human +DTXSID4029195 TK.Half.Life NA 6.172 hours 1compartment NA NA Rat Human +DTXSID4029195 Css NA 0.01628 mg/L 3compartmentss NA 50% Rat Human +DTXSID4029195 Css NA 0.1508 mg/L 3compartmentss NA 95% Rat Human +DTXSID4029195 Css NA 0.01549 mg/L PBTK NA 50% Rat Human +DTXSID4029195 Css NA 0.1051 mg/L PBTK NA 95% Rat Human +DTXSID4029220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029220 Fup 0.732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029220 Vd NA 2.076 L/kg 1compartment NA NA Human Human DTXSID4029220 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4029220 TK.Half.Life NA 3.612 hours 1compartment NA NA Human Human -DTXSID4029220 Css NA 0.1146 mg/L 3compartmentss NA 50% Human Human -DTXSID4029220 Css NA 0.5925 mg/L 3compartmentss NA 95% Human Human -DTXSID4029220 Css NA 0.1215 mg/L PBTK NA 50% Human Human -DTXSID4029220 Css NA 0.5313 mg/L PBTK NA 95% Human Human -DTXSID4029220 Clint NA 3.066 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029220 Fup NA 0.9489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029220 Vd NA 2.466 L/kg 1compartment NA NA Rat Human +DTXSID4029220 TK.Half.Life NA 1.478 hours 1compartment NA NA Human Human +DTXSID4029220 Css NA 0.0186 mg/L 3compartmentss NA 50% Human Human +DTXSID4029220 Css NA 0.2449 mg/L 3compartmentss NA 95% Human Human +DTXSID4029220 Css NA 0.01842 mg/L PBTK NA 50% Human Human +DTXSID4029220 Css NA 0.1894 mg/L PBTK NA 95% Human Human +DTXSID4029220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029220 Fup 0.732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029220 Vd NA 2.068 L/kg 1compartment NA NA Rat Human DTXSID4029220 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4029220 TK.Half.Life NA 1.895 hours 1compartment NA NA Rat Human -DTXSID4029220 Css NA 0.05058 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029220 Css NA 0.2102 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029220 Css NA 0.05468 mg/L PBTK NA 50% Rat Human -DTXSID4029220 Css NA 0.17 mg/L PBTK NA 95% Rat Human +DTXSID4029220 TK.Half.Life NA 0.7321 hours 1compartment NA NA Rat Human +DTXSID4029220 Css NA 0.0006264 mg/L 3compartmentss NA 50% Rat Human +DTXSID4029220 Css NA 0.01002 mg/L 3compartmentss NA 95% Rat Human +DTXSID4029220 Css NA 0.000626 mg/L PBTK NA 50% Rat Human +DTXSID4029220 Css NA 0.00746 mg/L PBTK NA 95% Rat Human DTXSID4029224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4029224 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029224 Vd NA 0.8476 L/kg 1compartment NA NA Human Human +DTXSID4029224 Vd NA 0.8289 L/kg 1compartment NA NA Human Human DTXSID4029224 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4029224 TK.Half.Life NA 5.497 hours 1compartment NA NA Human Human -DTXSID4029224 Css NA 0.8099 mg/L 3compartmentss NA 50% Human Human -DTXSID4029224 Css NA 5.674 mg/L 3compartmentss NA 95% Human Human -DTXSID4029224 Css NA 0.6964 mg/L PBTK NA 50% Human Human -DTXSID4029224 Css NA 3.672 mg/L PBTK NA 95% Human Human +DTXSID4029224 TK.Half.Life NA 5.365 hours 1compartment NA NA Human Human +DTXSID4029224 Css NA 0.6823 mg/L 3compartmentss NA 50% Human Human +DTXSID4029224 Css NA 4.957 mg/L 3compartmentss NA 95% Human Human +DTXSID4029224 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID4029224 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID4029224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4029224 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029224 Vd NA 0.8755 L/kg 1compartment NA NA Rat Human +DTXSID4029224 Vd NA 0.8632 L/kg 1compartment NA NA Rat Human DTXSID4029224 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4029224 TK.Half.Life NA 1.931 hours 1compartment NA NA Rat Human -DTXSID4029224 Css NA 0.2039 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029224 Css NA 1.236 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029224 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID4029224 Css NA 0.7536 mg/L PBTK NA 95% Rat Human -DTXSID4029359 Clint NA 0.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029359 Fup NA 0.8075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029359 Vd NA 2.498 L/kg 1compartment NA NA Human Human -DTXSID4029359 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4029359 TK.Half.Life NA 12.67 hours 1compartment NA NA Human Human -DTXSID4029359 Css NA 0.4622 mg/L 3compartmentss NA 50% Human Human -DTXSID4029359 Css NA 3.266 mg/L 3compartmentss NA 95% Human Human -DTXSID4029359 Css NA 0.5072 mg/L PBTK NA 50% Human Human -DTXSID4029359 Css NA 2.341 mg/L PBTK NA 95% Human Human -DTXSID4029359 Clint NA 0.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029359 Fup NA 0.8075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029359 Vd NA 2.538 L/kg 1compartment NA NA Rat Human -DTXSID4029359 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4029359 TK.Half.Life NA 5.39 hours 1compartment NA NA Rat Human -DTXSID4029359 Css NA 0.1443 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029359 Css NA 1.108 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029359 Css NA 0.1572 mg/L PBTK NA 50% Rat Human -DTXSID4029359 Css NA 0.7313 mg/L PBTK NA 95% Rat Human -DTXSID4029565 Clint NA 184.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029565 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029565 Vd NA 19740 L/kg 1compartment NA NA Human Human -DTXSID4029565 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4029565 TK.Half.Life NA 70140 hours 1compartment NA NA Human Human -DTXSID4029565 Css NA 7.894e-05 mg/L 3compartmentss NA 50% Human Human -DTXSID4029565 Css NA 0.0004927 mg/L 3compartmentss NA 95% Human Human -DTXSID4029565 Css NA 0.2955 mg/L PBTK NA 50% Human Human -DTXSID4029565 Css NA 1.675 mg/L PBTK NA 95% Human Human -DTXSID4029565 Clint NA 184.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029565 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029565 Vd NA 18650 L/kg 1compartment NA NA Rat Human -DTXSID4029565 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID4029565 TK.Half.Life NA 12400 hours 1compartment NA NA Rat Human -DTXSID4029565 Css NA 4.022e-05 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029565 Css NA 0.000168 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029565 Css NA 0.161 mg/L PBTK NA 50% Rat Human -DTXSID4029565 Css NA 0.6776 mg/L PBTK NA 95% Rat Human -DTXSID4029690 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029690 Fup NA 0.7231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029690 Vd NA 0.5748 L/kg 1compartment NA NA Human Human -DTXSID4029690 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4029690 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human -DTXSID4029690 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human -DTXSID4029690 Css NA 6.84 mg/L 3compartmentss NA 95% Human Human -DTXSID4029690 Css NA 0.8676 mg/L PBTK NA 50% Human Human -DTXSID4029690 Css NA 4.217 mg/L PBTK NA 95% Human Human -DTXSID4029690 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029690 Fup NA 0.7231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029690 Vd NA 0.6163 L/kg 1compartment NA NA Rat Human -DTXSID4029690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4029690 TK.Half.Life NA 1.879 hours 1compartment NA NA Rat Human -DTXSID4029690 Css NA 0.2872 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029690 Css NA 1.754 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029690 Css NA 0.2162 mg/L PBTK NA 50% Rat Human -DTXSID4029690 Css NA 1.026 mg/L PBTK NA 95% Rat Human -DTXSID4029692 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029692 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029692 Vd NA 2.278 L/kg 1compartment NA NA Human Human -DTXSID4029692 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID4029692 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human -DTXSID4029692 Css NA 5.766 mg/L 3compartmentss NA 50% Human Human -DTXSID4029692 Css NA 18.35 mg/L 3compartmentss NA 95% Human Human -DTXSID4029692 Css NA 4.315 mg/L PBTK NA 50% Human Human -DTXSID4029692 Css NA 12.3 mg/L PBTK NA 95% Human Human -DTXSID4029692 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029692 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029692 Vd NA 1.758 L/kg 1compartment NA NA Rat Human -DTXSID4029692 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID4029692 TK.Half.Life NA 18.69 hours 1compartment NA NA Rat Human -DTXSID4029692 Css NA 1.568 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029692 Css NA 4.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029692 Css NA 1.13 mg/L PBTK NA 50% Rat Human -DTXSID4029692 Css NA 2.563 mg/L PBTK NA 95% Rat Human -DTXSID4029698 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029698 Fup NA 0.7231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029698 Vd NA 0.5748 L/kg 1compartment NA NA Human Human -DTXSID4029698 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4029698 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human -DTXSID4029698 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human -DTXSID4029698 Css NA 6.84 mg/L 3compartmentss NA 95% Human Human -DTXSID4029698 Css NA 0.8676 mg/L PBTK NA 50% Human Human -DTXSID4029698 Css NA 4.217 mg/L PBTK NA 95% Human Human -DTXSID4029698 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029698 Fup NA 0.7231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029698 Vd NA 0.6163 L/kg 1compartment NA NA Rat Human -DTXSID4029698 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4029698 TK.Half.Life NA 1.879 hours 1compartment NA NA Rat Human -DTXSID4029698 Css NA 0.2872 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029698 Css NA 1.754 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029698 Css NA 0.2162 mg/L PBTK NA 50% Rat Human -DTXSID4029698 Css NA 1.026 mg/L PBTK NA 95% Rat Human -DTXSID4029806 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029806 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4029806 Vd NA 0.5326 L/kg 1compartment NA NA Human Human -DTXSID4029806 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4029806 TK.Half.Life NA 9.524 hours 1compartment NA NA Human Human -DTXSID4029806 Css NA 3.125 mg/L 3compartmentss NA 50% Human Human -DTXSID4029806 Css NA 32.01 mg/L 3compartmentss NA 95% Human Human -DTXSID4029806 Css NA 1.898 mg/L PBTK NA 50% Human Human -DTXSID4029806 Css NA 18.94 mg/L PBTK NA 95% Human Human -DTXSID4029806 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029806 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4029806 Vd NA 0.4356 L/kg 1compartment NA NA Rat Human -DTXSID4029806 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4029806 TK.Half.Life NA 5.154 hours 1compartment NA NA Rat Human -DTXSID4029806 Css NA 1.819 mg/L 3compartmentss NA 50% Rat Human -DTXSID4029806 Css NA 15.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID4029806 Css NA 1.034 mg/L PBTK NA 50% Rat Human -DTXSID4029806 Css NA 8.561 mg/L PBTK NA 95% Rat Human -DTXSID4030384 Clint NA 6.316 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4030384 Fup NA 0.2564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4030384 Vd NA 2.164 L/kg 1compartment NA NA Human Human +DTXSID4029224 TK.Half.Life NA 1.903 hours 1compartment NA NA Rat Human +DTXSID4029224 Css NA 0.01245 mg/L 3compartmentss NA 50% Rat Human +DTXSID4029224 Css NA 0.0981 mg/L 3compartmentss NA 95% Rat Human +DTXSID4029224 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID4029224 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID4029270 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029270 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029270 Vd NA 2.915 L/kg 1compartment NA NA Human Human +DTXSID4029270 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4029270 TK.Half.Life NA 19.37 hours 1compartment NA NA Human Human +DTXSID4029270 Css NA 0.736 mg/L 3compartmentss NA 50% Human Human +DTXSID4029270 Css NA 4.867 mg/L 3compartmentss NA 95% Human Human +DTXSID4029270 Css NA 0.5156 mg/L PBTK NA 50% Human Human +DTXSID4029270 Css NA 3.293 mg/L PBTK NA 95% Human Human +DTXSID4029270 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029270 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029270 Vd NA 2.194 L/kg 1compartment NA NA Rat Human +DTXSID4029270 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4029270 TK.Half.Life NA 3.689 hours 1compartment NA NA Rat Human +DTXSID4029270 Css NA 0.09426 mg/L 3compartmentss NA 50% Rat Human +DTXSID4029270 Css NA 0.4846 mg/L 3compartmentss NA 95% Rat Human +DTXSID4029270 Css NA 0.06551 mg/L PBTK NA 50% Rat Human +DTXSID4029270 Css NA 0.3289 mg/L PBTK NA 95% Rat Human +DTXSID4029353 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029353 Fup 0.0393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029353 Vd NA 3.126 L/kg 1compartment NA NA Human Human +DTXSID4029353 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID4029353 TK.Half.Life NA 88.48 hours 1compartment NA NA Human Human +DTXSID4029353 Css NA 3.344 mg/L 3compartmentss NA 50% Human Human +DTXSID4029353 Css NA 20.99 mg/L 3compartmentss NA 95% Human Human +DTXSID4029353 Css NA 2.323 mg/L PBTK NA 50% Human Human +DTXSID4029353 Css NA 14.08 mg/L PBTK NA 95% Human Human +DTXSID4029353 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029353 Fup 0.0393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029353 Vd NA 2.341 L/kg 1compartment NA NA Rat Human +DTXSID4029353 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID4029353 TK.Half.Life NA 11.81 hours 1compartment NA NA Rat Human +DTXSID4029353 Css NA 0.4338 mg/L 3compartmentss NA 50% Rat Human +DTXSID4029353 Css NA 2.352 mg/L 3compartmentss NA 95% Rat Human +DTXSID4029353 Css NA 0.298 mg/L PBTK NA 50% Rat Human +DTXSID4029353 Css NA 1.572 mg/L PBTK NA 95% Rat Human +DTXSID4029359 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029359 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4029359 Vd NA 1.413 L/kg 1compartment NA NA Human Human +DTXSID4029359 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4029359 TK.Half.Life NA 30.68 hours 1compartment NA NA Human Human +DTXSID4029359 Css NA 1.802 mg/L 3compartmentss NA 50% Human Human +DTXSID4029359 Css NA 7.906 mg/L 3compartmentss NA 95% Human Human +DTXSID4029359 Css NA 1.495 mg/L PBTK NA 50% Human Human +DTXSID4029359 Css NA 5.369 mg/L PBTK NA 95% Human Human +DTXSID4029359 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029359 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4029359 Vd NA 1.418 L/kg 1compartment NA NA Rat Human +DTXSID4029359 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4029359 TK.Half.Life NA 10.49 hours 1compartment NA NA Rat Human +DTXSID4029359 Css NA 0.03268 mg/L 3compartmentss NA 50% Rat Human +DTXSID4029359 Css NA 0.2092 mg/L 3compartmentss NA 95% Rat Human +DTXSID4029359 Css NA 0.0262 mg/L PBTK NA 50% Rat Human +DTXSID4029359 Css NA 0.1448 mg/L PBTK NA 95% Rat Human +DTXSID4030047 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4030047 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4030047 Vd NA 80.71 L/kg 1compartment NA NA Human Human +DTXSID4030047 Days.Css NA 8526 Days PBTK NA NA Human Human +DTXSID4030047 TK.Half.Life NA 3851000 hours 1compartment NA NA Human Human +DTXSID4030047 Css NA 323 mg/L 3compartmentss NA 50% Human Human +DTXSID4030047 Css NA 889.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4030047 Css NA 3099 mg/L PBTK NA 50% Human Human +DTXSID4030047 Css NA 6949 mg/L PBTK NA 95% Human Human +DTXSID4030047 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4030047 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4030047 Vd NA 69.25 L/kg 1compartment NA NA Rat Human +DTXSID4030047 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID4030047 TK.Half.Life NA 274600 hours 1compartment NA NA Rat Human +DTXSID4030047 Css NA 4.87 mg/L 3compartmentss NA 50% Rat Human +DTXSID4030047 Css NA 24.92 mg/L 3compartmentss NA 95% Rat Human +DTXSID4030047 Css NA 50.38 mg/L PBTK NA 50% Rat Human +DTXSID4030047 Css NA 226.9 mg/L PBTK NA 95% Rat Human +DTXSID4030384 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4030384 Fup 0.0806 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4030384 Vd NA 1.348 L/kg 1compartment NA NA Human Human DTXSID4030384 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4030384 TK.Half.Life NA 9.369 hours 1compartment NA NA Human Human -DTXSID4030384 Css NA 0.4341 mg/L 3compartmentss NA 50% Human Human -DTXSID4030384 Css NA 2.423 mg/L 3compartmentss NA 95% Human Human -DTXSID4030384 Css NA 0.3231 mg/L PBTK NA 50% Human Human -DTXSID4030384 Css NA 1.673 mg/L PBTK NA 95% Human Human -DTXSID4030384 Clint NA 6.316 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4030384 Fup NA 0.2564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4030384 Vd NA 1.674 L/kg 1compartment NA NA Rat Human +DTXSID4030384 TK.Half.Life NA 4.335 hours 1compartment NA NA Human Human +DTXSID4030384 Css NA 0.3725 mg/L 3compartmentss NA 50% Human Human +DTXSID4030384 Css NA 2.873 mg/L 3compartmentss NA 95% Human Human +DTXSID4030384 Css NA 0.2422 mg/L PBTK NA 50% Human Human +DTXSID4030384 Css NA 1.785 mg/L PBTK NA 95% Human Human +DTXSID4030384 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4030384 Fup 0.0806 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4030384 Vd NA 1.03 L/kg 1compartment NA NA Rat Human DTXSID4030384 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4030384 TK.Half.Life NA 2.917 hours 1compartment NA NA Rat Human -DTXSID4030384 Css NA 0.2205 mg/L 3compartmentss NA 50% Rat Human -DTXSID4030384 Css NA 0.8974 mg/L 3compartmentss NA 95% Rat Human -DTXSID4030384 Css NA 0.1588 mg/L PBTK NA 50% Rat Human -DTXSID4030384 Css NA 0.5837 mg/L PBTK NA 95% Rat Human -DTXSID4031356 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4031356 Fup NA 0.9814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4031356 Vd NA 0.7556 L/kg 1compartment NA NA Human Human +DTXSID4030384 TK.Half.Life NA 1.745 hours 1compartment NA NA Rat Human +DTXSID4030384 Css NA 0.04872 mg/L 3compartmentss NA 50% Rat Human +DTXSID4030384 Css NA 0.2855 mg/L 3compartmentss NA 95% Rat Human +DTXSID4030384 Css NA 0.03089 mg/L PBTK NA 50% Rat Human +DTXSID4030384 Css NA 0.1736 mg/L PBTK NA 95% Rat Human +DTXSID4031356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4031356 Fup 0.835 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4031356 Vd NA 0.4432 L/kg 1compartment NA NA Human Human DTXSID4031356 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4031356 TK.Half.Life NA 4.983 hours 1compartment NA NA Human Human -DTXSID4031356 Css NA 0.8276 mg/L 3compartmentss NA 50% Human Human -DTXSID4031356 Css NA 6.404 mg/L 3compartmentss NA 95% Human Human -DTXSID4031356 Css NA 0.6858 mg/L PBTK NA 50% Human Human -DTXSID4031356 Css NA 3.958 mg/L PBTK NA 95% Human Human -DTXSID4031356 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4031356 Fup NA 0.9814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4031356 Vd NA 0.8006 L/kg 1compartment NA NA Rat Human +DTXSID4031356 TK.Half.Life NA 3.433 hours 1compartment NA NA Human Human +DTXSID4031356 Css NA 0.9385 mg/L 3compartmentss NA 50% Human Human +DTXSID4031356 Css NA 5.155 mg/L 3compartmentss NA 95% Human Human +DTXSID4031356 Css NA 0.6866 mg/L PBTK NA 50% Human Human +DTXSID4031356 Css NA 3.222 mg/L PBTK NA 95% Human Human +DTXSID4031356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4031356 Fup 0.835 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4031356 Vd NA 0.4712 L/kg 1compartment NA NA Rat Human DTXSID4031356 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4031356 TK.Half.Life NA 1.799 hours 1compartment NA NA Rat Human -DTXSID4031356 Css NA 0.2098 mg/L 3compartmentss NA 50% Rat Human -DTXSID4031356 Css NA 1.639 mg/L 3compartmentss NA 95% Rat Human -DTXSID4031356 Css NA 0.17 mg/L PBTK NA 50% Rat Human -DTXSID4031356 Css NA 0.9628 mg/L PBTK NA 95% Rat Human -DTXSID4031566 Clint NA 16.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4031566 Fup NA 0.1895 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4031566 Vd NA 1.473 L/kg 1compartment NA NA Human Human +DTXSID4031356 TK.Half.Life NA 1.244 hours 1compartment NA NA Rat Human +DTXSID4031356 Css NA 0.0246 mg/L 3compartmentss NA 50% Rat Human +DTXSID4031356 Css NA 0.1529 mg/L 3compartmentss NA 95% Rat Human +DTXSID4031356 Css NA 0.01722 mg/L PBTK NA 50% Rat Human +DTXSID4031356 Css NA 0.09359 mg/L PBTK NA 95% Rat Human +DTXSID4031566 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4031566 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4031566 Vd NA 3.04 L/kg 1compartment NA NA Human Human DTXSID4031566 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4031566 TK.Half.Life NA 2.799 hours 1compartment NA NA Human Human -DTXSID4031566 Css NA 0.1423 mg/L 3compartmentss NA 50% Human Human -DTXSID4031566 Css NA 1.024 mg/L 3compartmentss NA 95% Human Human -DTXSID4031566 Css NA 0.1092 mg/L PBTK NA 50% Human Human -DTXSID4031566 Css NA 0.7249 mg/L PBTK NA 95% Human Human -DTXSID4031566 Clint NA 16.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4031566 Fup NA 0.1895 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4031566 Vd NA 1.385 L/kg 1compartment NA NA Rat Human +DTXSID4031566 TK.Half.Life NA 3.549 hours 1compartment NA NA Human Human +DTXSID4031566 Css NA 0.0569 mg/L 3compartmentss NA 50% Human Human +DTXSID4031566 Css NA 0.4333 mg/L 3compartmentss NA 95% Human Human +DTXSID4031566 Css NA 0.05334 mg/L PBTK NA 50% Human Human +DTXSID4031566 Css NA 0.3604 mg/L PBTK NA 95% Human Human +DTXSID4031566 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4031566 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4031566 Vd NA 2.733 L/kg 1compartment NA NA Rat Human DTXSID4031566 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4031566 TK.Half.Life NA 1.478 hours 1compartment NA NA Rat Human -DTXSID4031566 Css NA 0.0772 mg/L 3compartmentss NA 50% Rat Human -DTXSID4031566 Css NA 0.412 mg/L 3compartmentss NA 95% Rat Human -DTXSID4031566 Css NA 0.05688 mg/L PBTK NA 50% Rat Human -DTXSID4031566 Css NA 0.2703 mg/L PBTK NA 95% Rat Human +DTXSID4031566 TK.Half.Life NA 1.448 hours 1compartment NA NA Rat Human +DTXSID4031566 Css NA 0.0069 mg/L 3compartmentss NA 50% Rat Human +DTXSID4031566 Css NA 0.03977 mg/L 3compartmentss NA 95% Rat Human +DTXSID4031566 Css NA 0.006724 mg/L PBTK NA 50% Rat Human +DTXSID4031566 Css NA 0.03312 mg/L PBTK NA 95% Rat Human DTXSID4031980 Clint 62.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4031980 Fup 5.86e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4031980 Vd NA 0.1862 L/kg 1compartment NA NA Human Human -DTXSID4031980 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID4031980 TK.Half.Life NA 81.79 hours 1compartment NA NA Human Human -DTXSID4031980 Css NA 0.8558 mg/L 3compartmentss NA 50% Human Human -DTXSID4031980 Css NA 12.12 mg/L 3compartmentss NA 95% Human Human -DTXSID4031980 Css NA 0.5195 mg/L PBTK NA 50% Human Human -DTXSID4031980 Css NA 7.085 mg/L PBTK NA 95% Human Human +DTXSID4031980 Vd NA 0.1776 L/kg 1compartment NA NA Human Human +DTXSID4031980 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID4031980 TK.Half.Life NA 83.74 hours 1compartment NA NA Human Human +DTXSID4031980 Css NA 0.855 mg/L 3compartmentss NA 50% Human Human +DTXSID4031980 Css NA 12.69 mg/L 3compartmentss NA 95% Human Human +DTXSID4031980 Css NA 0.5157 mg/L PBTK NA 50% Human Human +DTXSID4031980 Css NA 7.495 mg/L PBTK NA 95% Human Human DTXSID4031980 Clint 62.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4031980 Fup 5.86e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4031980 Vd NA 0.1712 L/kg 1compartment NA NA Rat Human -DTXSID4031980 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID4031980 TK.Half.Life NA 52.43 hours 1compartment NA NA Rat Human -DTXSID4031980 Css NA 0.4819 mg/L 3compartmentss NA 50% Rat Human -DTXSID4031980 Css NA 5.948 mg/L 3compartmentss NA 95% Rat Human -DTXSID4031980 Css NA 0.2732 mg/L PBTK NA 50% Rat Human -DTXSID4031980 Css NA 3.26 mg/L PBTK NA 95% Rat Human +DTXSID4031980 Vd NA 0.1669 L/kg 1compartment NA NA Rat Human +DTXSID4031980 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID4031980 TK.Half.Life NA 54.84 hours 1compartment NA NA Rat Human +DTXSID4031980 Css NA 0.1105 mg/L 3compartmentss NA 50% Rat Human +DTXSID4031980 Css NA 1.434 mg/L 3compartmentss NA 95% Rat Human +DTXSID4031980 Css NA 0.06392 mg/L PBTK NA 50% Rat Human +DTXSID4031980 Css NA 0.8107 mg/L PBTK NA 95% Rat Human DTXSID4032372 Clint 30.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4032372 Fup 0.0115 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4032372 Vd NA 2.278 L/kg 1compartment NA NA Human Human DTXSID4032372 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID4032372 TK.Half.Life NA 25.47 hours 1compartment NA NA Human Human -DTXSID4032372 Css NA 1.304 mg/L 3compartmentss NA 50% Human Human -DTXSID4032372 Css NA 7.968 mg/L 3compartmentss NA 95% Human Human -DTXSID4032372 Css NA 0.8615 mg/L PBTK NA 50% Human Human -DTXSID4032372 Css NA 5.1 mg/L PBTK NA 95% Human Human +DTXSID4032372 Css NA 1.261 mg/L 3compartmentss NA 50% Human Human +DTXSID4032372 Css NA 7.983 mg/L 3compartmentss NA 95% Human Human +DTXSID4032372 Css NA 0.8391 mg/L PBTK NA 50% Human Human +DTXSID4032372 Css NA 5.165 mg/L PBTK NA 95% Human Human DTXSID4032372 Clint 30.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4032372 Fup 0.0115 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4032372 Vd NA 1.694 L/kg 1compartment NA NA Rat Human DTXSID4032372 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID4032372 TK.Half.Life NA 7.177 hours 1compartment NA NA Rat Human -DTXSID4032372 Css NA 0.7272 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032372 Css NA 3.772 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032372 Css NA 0.4557 mg/L PBTK NA 50% Rat Human -DTXSID4032372 Css NA 2.3 mg/L PBTK NA 95% Rat Human -DTXSID4032374 Clint NA 10.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032374 Fup NA 0.0014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032374 Vd NA 10.18 L/kg 1compartment NA NA Human Human -DTXSID4032374 Days.Css NA 250 Days PBTK NA NA Human Human -DTXSID4032374 TK.Half.Life NA 1017 hours 1compartment NA NA Human Human -DTXSID4032374 Css NA 10.09 mg/L 3compartmentss NA 50% Human Human -DTXSID4032374 Css NA 89.02 mg/L 3compartmentss NA 95% Human Human -DTXSID4032374 Css NA 11.09 mg/L PBTK NA 50% Human Human -DTXSID4032374 Css NA 74.14 mg/L PBTK NA 95% Human Human -DTXSID4032374 Clint NA 10.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032374 Fup NA 0.0014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032374 Vd NA 8.028 L/kg 1compartment NA NA Rat Human -DTXSID4032374 Days.Css NA 142 Days PBTK NA NA Rat Human -DTXSID4032374 TK.Half.Life NA 448.3 hours 1compartment NA NA Rat Human -DTXSID4032374 Css NA 5.368 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032374 Css NA 39.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032374 Css NA 5.824 mg/L PBTK NA 50% Rat Human -DTXSID4032374 Css NA 31.86 mg/L PBTK NA 95% Rat Human +DTXSID4032372 Css NA 0.1613 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032372 Css NA 0.9383 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032372 Css NA 0.1049 mg/L PBTK NA 50% Rat Human +DTXSID4032372 Css NA 0.6079 mg/L PBTK NA 95% Rat Human +DTXSID4032374 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032374 Fup 0.00417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032374 Vd NA 3.028 L/kg 1compartment NA NA Human Human +DTXSID4032374 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID4032374 TK.Half.Life NA 90.43 hours 1compartment NA NA Human Human +DTXSID4032374 Css NA 3.229 mg/L 3compartmentss NA 50% Human Human +DTXSID4032374 Css NA 20.67 mg/L 3compartmentss NA 95% Human Human +DTXSID4032374 Css NA 2.216 mg/L PBTK NA 50% Human Human +DTXSID4032374 Css NA 13.75 mg/L PBTK NA 95% Human Human +DTXSID4032374 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032374 Fup 0.00417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032374 Vd NA 2.264 L/kg 1compartment NA NA Rat Human +DTXSID4032374 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID4032374 TK.Half.Life NA 13.67 hours 1compartment NA NA Rat Human +DTXSID4032374 Css NA 0.1627 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032374 Css NA 1.05 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032374 Css NA 0.109 mg/L PBTK NA 50% Rat Human +DTXSID4032374 Css NA 0.6839 mg/L PBTK NA 95% Rat Human DTXSID4032376 Clint 19.92 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4032376 Fup 0.2318 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4032376 Vd NA 1.357 L/kg 1compartment NA NA Human Human DTXSID4032376 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4032376 TK.Half.Life NA 2.054 hours 1compartment NA NA Human Human -DTXSID4032376 Css NA 0.1002 mg/L 3compartmentss NA 50% Human Human -DTXSID4032376 Css NA 0.6687 mg/L 3compartmentss NA 95% Human Human -DTXSID4032376 Css NA 0.0842 mg/L PBTK NA 50% Human Human -DTXSID4032376 Css NA 0.5047 mg/L PBTK NA 95% Human Human +DTXSID4032376 Css NA 0.08828 mg/L 3compartmentss NA 50% Human Human +DTXSID4032376 Css NA 0.5832 mg/L 3compartmentss NA 95% Human Human +DTXSID4032376 Css NA 0.07912 mg/L PBTK NA 50% Human Human +DTXSID4032376 Css NA 0.5231 mg/L PBTK NA 95% Human Human DTXSID4032376 Clint 101.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4032376 Fup 0.5372 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID4032376 Vd NA 1.628 L/kg 1compartment NA NA Rat Rat +DTXSID4032376 Vd 4.4 1.628 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID4032376 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4032376 TK.Half.Life NA 0.4937 hours 1compartment NA NA Rat Rat -DTXSID4032376 Css NA 0.006615 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4032376 Css NA 0.04984 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4032376 Css NA 0.004943 mg/L PBTK NA 50% Rat Rat -DTXSID4032376 Css NA 0.03367 mg/L PBTK NA 95% Rat Rat -DTXSID4032378 Clint NA 5.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032378 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032378 Vd NA 0.2447 L/kg 1compartment NA NA Human Human -DTXSID4032378 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4032378 TK.Half.Life NA 21.08 hours 1compartment NA NA Human Human -DTXSID4032378 Css NA 15.83 mg/L 3compartmentss NA 50% Human Human -DTXSID4032378 Css NA 137 mg/L 3compartmentss NA 95% Human Human -DTXSID4032378 Css NA 9.369 mg/L PBTK NA 50% Human Human -DTXSID4032378 Css NA 79.45 mg/L PBTK NA 95% Human Human -DTXSID4032378 Clint NA 5.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032378 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032378 Vd NA 0.2324 L/kg 1compartment NA NA Rat Human -DTXSID4032378 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4032378 TK.Half.Life NA 12.61 hours 1compartment NA NA Rat Human -DTXSID4032378 Css NA 8.336 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032378 Css NA 56.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032378 Css NA 4.608 mg/L PBTK NA 50% Rat Human -DTXSID4032378 Css NA 30.75 mg/L PBTK NA 95% Rat Human +DTXSID4032376 TK.Half.Life 0.11 0.4937 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID4032376 Css 0.0014 0.001102 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID4032376 Css 0.0014 0.008151 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID4032376 Css 0.0014 0.001031 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID4032376 Css 0.0014 0.007588 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID4032378 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032378 Fup 0.00641 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032378 Vd NA 1.922 L/kg 1compartment NA NA Human Human +DTXSID4032378 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4032378 TK.Half.Life NA 38.3 hours 1compartment NA NA Human Human +DTXSID4032378 Css NA 3.187 mg/L 3compartmentss NA 50% Human Human +DTXSID4032378 Css NA 26.33 mg/L 3compartmentss NA 95% Human Human +DTXSID4032378 Css NA 2.007 mg/L PBTK NA 50% Human Human +DTXSID4032378 Css NA 16.04 mg/L PBTK NA 95% Human Human +DTXSID4032378 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032378 Fup 0.00641 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032378 Vd NA 1.421 L/kg 1compartment NA NA Rat Human +DTXSID4032378 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4032378 TK.Half.Life NA 12.67 hours 1compartment NA NA Rat Human +DTXSID4032378 Css NA 0.4089 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032378 Css NA 2.915 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032378 Css NA 0.2516 mg/L PBTK NA 50% Rat Human +DTXSID4032378 Css NA 1.734 mg/L PBTK NA 95% Rat Human DTXSID4032405 Clint 13.72 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4032405 Fup 0.8853 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID4032405 Vd NA 4.232 L/kg 1compartment NA NA Human Human +DTXSID4032405 Vd NA 5.019 L/kg 1compartment NA NA Human Human DTXSID4032405 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4032405 TK.Half.Life NA 3.993 hours 1compartment NA NA Human Human -DTXSID4032405 Css NA 0.0475 mg/L 3compartmentss NA 50% Human Human -DTXSID4032405 Css NA 0.4121 mg/L 3compartmentss NA 95% Human Human -DTXSID4032405 Css NA 0.03324 mg/L PBTK NA 50% Human Human -DTXSID4032405 Css NA 0.2655 mg/L PBTK NA 95% Human Human +DTXSID4032405 TK.Half.Life NA 4.757 hours 1compartment NA NA Human Human +DTXSID4032405 Css NA 0.04283 mg/L 3compartmentss NA 50% Human Human +DTXSID4032405 Css NA 0.3457 mg/L 3compartmentss NA 95% Human Human +DTXSID4032405 Css NA 0.03104 mg/L PBTK NA 50% Human Human +DTXSID4032405 Css NA 0.2519 mg/L PBTK NA 95% Human Human DTXSID4032405 Clint 11.18 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4032405 Fup 0.7485 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID4032405 Vd NA 3.832 L/kg 1compartment NA NA Rat Rat +DTXSID4032405 Vd 44 4.556 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID4032405 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4032405 TK.Half.Life NA 2.05 hours 1compartment NA NA Rat Rat -DTXSID4032405 Css NA 0.03152 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4032405 Css NA 0.2403 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4032405 Css NA 0.02171 mg/L PBTK NA 50% Rat Rat -DTXSID4032405 Css NA 0.1411 mg/L PBTK NA 95% Rat Rat +DTXSID4032405 TK.Half.Life 36 2.42 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID4032405 Css 0.05 0.006454 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID4032405 Css 0.05 0.04181 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID4032405 Css 0.05 0.004893 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID4032405 Css 0.05 0.03164 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID4032459 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4032459 Fup 0.0129 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4032459 Vd NA 1.521 L/kg 1compartment NA NA Human Human -DTXSID4032459 Days.Css NA 292 Days PBTK NA NA Human Human +DTXSID4032459 Days.Css NA 288 Days PBTK NA NA Human Human DTXSID4032459 TK.Half.Life NA 1115 hours 1compartment NA NA Human Human -DTXSID4032459 Css NA 113.8 mg/L 3compartmentss NA 50% Human Human -DTXSID4032459 Css NA 596.8 mg/L 3compartmentss NA 95% Human Human -DTXSID4032459 Css NA 70.97 mg/L PBTK NA 50% Human Human -DTXSID4032459 Css NA 351.1 mg/L PBTK NA 95% Human Human +DTXSID4032459 Css NA 111.7 mg/L 3compartmentss NA 50% Human Human +DTXSID4032459 Css NA 570.4 mg/L 3compartmentss NA 95% Human Human +DTXSID4032459 Css NA 69.18 mg/L PBTK NA 50% Human Human +DTXSID4032459 Css NA 335 mg/L PBTK NA 95% Human Human DTXSID4032459 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4032459 Fup 0.0129 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4032459 Vd NA 1.124 L/kg 1compartment NA NA Rat Human DTXSID4032459 Days.Css NA 69 Days PBTK NA NA Rat Human DTXSID4032459 TK.Half.Life NA 213.3 hours 1compartment NA NA Rat Human -DTXSID4032459 Css NA 32.17 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032459 Css NA 143.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032459 Css NA 18.76 mg/L PBTK NA 50% Rat Human -DTXSID4032459 Css NA 78.89 mg/L PBTK NA 95% Rat Human +DTXSID4032459 Css NA 7.266 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032459 Css NA 30.87 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032459 Css NA 4.386 mg/L PBTK NA 50% Rat Human +DTXSID4032459 Css NA 17.57 mg/L PBTK NA 95% Rat Human DTXSID4032532 Clint 854 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4032532 Fup NA 0.0219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032532 Vd NA 0.8346 L/kg 1compartment NA NA Human Human +DTXSID4032532 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032532 Vd NA 1.771 L/kg 1compartment NA NA Human Human DTXSID4032532 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4032532 TK.Half.Life NA 0.9425 hours 1compartment NA NA Human Human -DTXSID4032532 Css NA 0.03635 mg/L 3compartmentss NA 50% Human Human -DTXSID4032532 Css NA 0.3526 mg/L 3compartmentss NA 95% Human Human -DTXSID4032532 Css NA 0.02189 mg/L PBTK NA 50% Human Human -DTXSID4032532 Css NA 0.2101 mg/L PBTK NA 95% Human Human +DTXSID4032532 TK.Half.Life NA 1.558 hours 1compartment NA NA Human Human +DTXSID4032532 Css NA 0.006042 mg/L 3compartmentss NA 50% Human Human +DTXSID4032532 Css NA 0.05902 mg/L 3compartmentss NA 95% Human Human +DTXSID4032532 Css NA 0.00406 mg/L PBTK NA 50% Human Human +DTXSID4032532 Css NA 0.03716 mg/L PBTK NA 95% Human Human DTXSID4032532 Clint 854 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4032532 Fup NA 0.0219 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032532 Vd NA 0.6244 L/kg 1compartment NA NA Rat Human +DTXSID4032532 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032532 Vd NA 1.341 L/kg 1compartment NA NA Rat Human DTXSID4032532 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4032532 TK.Half.Life NA 0.3329 hours 1compartment NA NA Rat Human -DTXSID4032532 Css NA 0.02021 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032532 Css NA 0.1769 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032532 Css NA 0.01142 mg/L PBTK NA 50% Rat Human -DTXSID4032532 Css NA 0.0989 mg/L PBTK NA 95% Rat Human -DTXSID4032536 Clint NA 73.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032536 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032536 Vd NA 3.108 L/kg 1compartment NA NA Human Human -DTXSID4032536 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4032536 TK.Half.Life NA 29.45 hours 1compartment NA NA Human Human -DTXSID4032536 Css NA 1.061 mg/L 3compartmentss NA 50% Human Human -DTXSID4032536 Css NA 6.068 mg/L 3compartmentss NA 95% Human Human -DTXSID4032536 Css NA 0.735 mg/L PBTK NA 50% Human Human -DTXSID4032536 Css NA 4.191 mg/L PBTK NA 95% Human Human -DTXSID4032536 Clint NA 73.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032536 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032536 Vd NA 2.327 L/kg 1compartment NA NA Rat Human -DTXSID4032536 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4032536 TK.Half.Life NA 4.368 hours 1compartment NA NA Rat Human -DTXSID4032536 Css NA 0.602 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032536 Css NA 2.602 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032536 Css NA 0.3981 mg/L PBTK NA 50% Rat Human -DTXSID4032536 Css NA 1.71 mg/L PBTK NA 95% Rat Human +DTXSID4032532 TK.Half.Life NA 0.5177 hours 1compartment NA NA Rat Human +DTXSID4032532 Css NA 0.0008534 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032532 Css NA 0.00685 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032532 Css NA 0.000567 mg/L PBTK NA 50% Rat Human +DTXSID4032532 Css NA 0.004353 mg/L PBTK NA 95% Rat Human +DTXSID4032536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032536 Fup 0.00547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032536 Vd NA 4.848 L/kg 1compartment NA NA Human Human +DTXSID4032536 Days.Css NA 27 Days PBTK NA NA Human Human +DTXSID4032536 TK.Half.Life NA 148.3 hours 1compartment NA NA Human Human +DTXSID4032536 Css NA 3.046 mg/L 3compartmentss NA 50% Human Human +DTXSID4032536 Css NA 17.29 mg/L 3compartmentss NA 95% Human Human +DTXSID4032536 Css NA 2.436 mg/L PBTK NA 50% Human Human +DTXSID4032536 Css NA 13.76 mg/L PBTK NA 95% Human Human +DTXSID4032536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032536 Fup 0.00547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032536 Vd NA 3.697 L/kg 1compartment NA NA Rat Human +DTXSID4032536 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID4032536 TK.Half.Life NA 21.04 hours 1compartment NA NA Rat Human +DTXSID4032536 Css NA 0.3945 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032536 Css NA 1.956 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032536 Css NA 0.3159 mg/L PBTK NA 50% Rat Human +DTXSID4032536 Css NA 1.603 mg/L PBTK NA 95% Rat Human DTXSID4032580 Clint 466 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4032580 Fup 0.0072 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4032580 Vd NA 0.9229 L/kg 1compartment NA NA Human Human +DTXSID4032580 Vd NA 2.309 L/kg 1compartment NA NA Human Human DTXSID4032580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4032580 TK.Half.Life NA 1.694 hours 1compartment NA NA Human Human -DTXSID4032580 Css NA 0.108 mg/L 3compartmentss NA 50% Human Human -DTXSID4032580 Css NA 1.021 mg/L 3compartmentss NA 95% Human Human -DTXSID4032580 Css NA 0.06568 mg/L PBTK NA 50% Human Human -DTXSID4032580 Css NA 0.6008 mg/L PBTK NA 95% Human Human +DTXSID4032580 TK.Half.Life NA 4.03 hours 1compartment NA NA Human Human +DTXSID4032580 Css NA 0.1061 mg/L 3compartmentss NA 50% Human Human +DTXSID4032580 Css NA 0.8887 mg/L 3compartmentss NA 95% Human Human +DTXSID4032580 Css NA 0.07033 mg/L PBTK NA 50% Human Human +DTXSID4032580 Css NA 0.5617 mg/L PBTK NA 95% Human Human DTXSID4032580 Clint 466 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4032580 Fup 0.0072 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4032580 Vd NA 0.6798 L/kg 1compartment NA NA Rat Human +DTXSID4032580 Vd NA 1.715 L/kg 1compartment NA NA Rat Human DTXSID4032580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4032580 TK.Half.Life NA 0.6614 hours 1compartment NA NA Rat Human -DTXSID4032580 Css NA 0.0628 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032580 Css NA 0.4767 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032580 Css NA 0.036 mg/L PBTK NA 50% Rat Human -DTXSID4032580 Css NA 0.2673 mg/L PBTK NA 95% Rat Human +DTXSID4032580 TK.Half.Life NA 1.209 hours 1compartment NA NA Rat Human +DTXSID4032580 Css NA 0.01431 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032580 Css NA 0.09717 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032580 Css NA 0.009336 mg/L PBTK NA 50% Rat Human +DTXSID4032580 Css NA 0.06085 mg/L PBTK NA 95% Rat Human DTXSID4032611 Clint 20.95 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4032611 Fup 0.09346 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4032611 Vd NA 2.599 L/kg 1compartment NA NA Human Human DTXSID4032611 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID4032611 TK.Half.Life NA 13.23 hours 1compartment NA NA Human Human -DTXSID4032611 Css NA 0.6564 mg/L 3compartmentss NA 50% Human Human -DTXSID4032611 Css NA 4.364 mg/L 3compartmentss NA 95% Human Human -DTXSID4032611 Css NA 0.4216 mg/L PBTK NA 50% Human Human -DTXSID4032611 Css NA 2.702 mg/L PBTK NA 95% Human Human +DTXSID4032611 Css NA 0.5018 mg/L 3compartmentss NA 50% Human Human +DTXSID4032611 Css NA 3.161 mg/L 3compartmentss NA 95% Human Human +DTXSID4032611 Css NA 0.4122 mg/L PBTK NA 50% Human Human +DTXSID4032611 Css NA 2.596 mg/L PBTK NA 95% Human Human DTXSID4032611 Clint 43.26 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4032611 Fup 0.1141 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4032611 Vd NA 2.025 L/kg 1compartment NA NA Rat Rat DTXSID4032611 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID4032611 TK.Half.Life NA 1.791 hours 1compartment NA NA Rat Rat -DTXSID4032611 Css NA 0.1735 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4032611 Css NA 0.883 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4032611 Css NA 0.1038 mg/L PBTK NA 50% Rat Rat -DTXSID4032611 Css NA 0.5219 mg/L PBTK NA 95% Rat Rat +DTXSID4032611 Css NA 0.02801 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4032611 Css NA 0.1574 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4032611 Css NA 0.02384 mg/L PBTK NA 50% Rat Rat +DTXSID4032611 Css NA 0.134 mg/L PBTK NA 95% Rat Rat DTXSID4032613 Clint 10.02 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID4032613 Fup NA 0.0459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032613 Vd NA 1.709 L/kg 1compartment NA NA Human Human +DTXSID4032613 Fup 0.0449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032613 Vd NA 1.694 L/kg 1compartment NA NA Human Human DTXSID4032613 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4032613 TK.Half.Life NA 17.38 hours 1compartment NA NA Human Human -DTXSID4032613 Css NA 1.538 mg/L 3compartmentss NA 50% Human Human -DTXSID4032613 Css NA 10.21 mg/L 3compartmentss NA 95% Human Human -DTXSID4032613 Css NA 0.989 mg/L PBTK NA 50% Human Human -DTXSID4032613 Css NA 6.299 mg/L PBTK NA 95% Human Human +DTXSID4032613 TK.Half.Life NA 17.44 hours 1compartment NA NA Human Human +DTXSID4032613 Css NA 1.534 mg/L 3compartmentss NA 50% Human Human +DTXSID4032613 Css NA 10.08 mg/L 3compartmentss NA 95% Human Human +DTXSID4032613 Css NA 0.9843 mg/L PBTK NA 50% Human Human +DTXSID4032613 Css NA 6.368 mg/L PBTK NA 95% Human Human DTXSID4032613 Clint 10.02 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID4032613 Fup NA 0.0459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032613 Vd NA 1.279 L/kg 1compartment NA NA Rat Human +DTXSID4032613 Fup 0.0449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032613 Vd NA 1.268 L/kg 1compartment NA NA Rat Human DTXSID4032613 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4032613 TK.Half.Life NA 6.194 hours 1compartment NA NA Rat Human -DTXSID4032613 Css NA 0.8366 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032613 Css NA 4.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032613 Css NA 0.5078 mg/L PBTK NA 50% Rat Human -DTXSID4032613 Css NA 2.386 mg/L PBTK NA 95% Rat Human +DTXSID4032613 TK.Half.Life NA 6.261 hours 1compartment NA NA Rat Human +DTXSID4032613 Css NA 0.191 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032613 Css NA 1.003 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032613 Css NA 0.1201 mg/L PBTK NA 50% Rat Human +DTXSID4032613 Css NA 0.5976 mg/L PBTK NA 95% Rat Human DTXSID4032615 Clint 7.521 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4032615 Fup 0.01727 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID4032615 Vd NA 0.1849 L/kg 1compartment NA NA Human Human +DTXSID4032615 Vd NA 0.189 L/kg 1compartment NA NA Human Human DTXSID4032615 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4032615 TK.Half.Life NA 5.291 hours 1compartment NA NA Human Human -DTXSID4032615 Css NA 5.305 mg/L 3compartmentss NA 50% Human Human -DTXSID4032615 Css NA 47.18 mg/L 3compartmentss NA 95% Human Human -DTXSID4032615 Css NA 3.117 mg/L PBTK NA 50% Human Human -DTXSID4032615 Css NA 27.2 mg/L PBTK NA 95% Human Human +DTXSID4032615 TK.Half.Life NA 5.407 hours 1compartment NA NA Human Human +DTXSID4032615 Css NA 3.22 mg/L 3compartmentss NA 50% Human Human +DTXSID4032615 Css NA 29.34 mg/L 3compartmentss NA 95% Human Human +DTXSID4032615 Css NA 1.888 mg/L PBTK NA 50% Human Human +DTXSID4032615 Css NA 17.26 mg/L PBTK NA 95% Human Human DTXSID4032615 Clint 7.521 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4032615 Fup 0.01727 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID4032615 Vd NA 0.1824 L/kg 1compartment NA NA Rat Human +DTXSID4032615 Vd NA 0.1859 L/kg 1compartment NA NA Rat Human DTXSID4032615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4032615 TK.Half.Life NA 3.355 hours 1compartment NA NA Rat Human -DTXSID4032615 Css NA 2.845 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032615 Css NA 19.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032615 Css NA 1.556 mg/L PBTK NA 50% Rat Human -DTXSID4032615 Css NA 10.6 mg/L PBTK NA 95% Rat Human -DTXSID4032619 Clint NA 3.879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032619 Fup NA 0.0506 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4032619 Vd NA 1.759 L/kg 1compartment NA NA Human Human -DTXSID4032619 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID4032619 TK.Half.Life NA 38.53 hours 1compartment NA NA Human Human -DTXSID4032619 Css NA 3.378 mg/L 3compartmentss NA 50% Human Human -DTXSID4032619 Css NA 20.14 mg/L 3compartmentss NA 95% Human Human -DTXSID4032619 Css NA 2.195 mg/L PBTK NA 50% Human Human -DTXSID4032619 Css NA 12.36 mg/L PBTK NA 95% Human Human -DTXSID4032619 Clint NA 3.879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032619 Fup NA 0.0506 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4032619 Vd NA 1.32 L/kg 1compartment NA NA Rat Human -DTXSID4032619 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4032619 TK.Half.Life NA 12.86 hours 1compartment NA NA Rat Human -DTXSID4032619 Css NA 1.762 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032619 Css NA 7.738 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032619 Css NA 1.074 mg/L PBTK NA 50% Rat Human -DTXSID4032619 Css NA 4.398 mg/L PBTK NA 95% Rat Human -DTXSID4032667 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4032667 Fup 3.58e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4032667 Vd NA 3.458 L/kg 1compartment NA NA Human Human -DTXSID4032667 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID4032667 TK.Half.Life NA 223800 hours 1compartment NA NA Human Human -DTXSID4032667 Css NA 6340 mg/L 3compartmentss NA 50% Human Human -DTXSID4032667 Css NA 12890 mg/L 3compartmentss NA 95% Human Human -DTXSID4032667 Css NA 4600 mg/L PBTK NA 50% Human Human -DTXSID4032667 Css NA 9145 mg/L PBTK NA 95% Human Human -DTXSID4032667 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4032667 Fup 3.58e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4032667 Vd NA 2.601 L/kg 1compartment NA NA Rat Human -DTXSID4032667 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID4032667 TK.Half.Life NA 57330 hours 1compartment NA NA Rat Human -DTXSID4032667 Css NA 1929 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032667 Css NA 1929 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032667 Css NA 1325 mg/L PBTK NA 50% Rat Human -DTXSID4032667 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID4032615 TK.Half.Life NA 3.42 hours 1compartment NA NA Rat Human +DTXSID4032615 Css NA 0.03865 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032615 Css NA 0.3505 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032615 Css NA 0.02119 mg/L PBTK NA 50% Rat Human +DTXSID4032615 Css NA 0.1902 mg/L PBTK NA 95% Rat Human +DTXSID4032619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032619 Fup 0.0289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4032619 Vd NA 1.389 L/kg 1compartment NA NA Human Human +DTXSID4032619 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4032619 TK.Half.Life NA 9.599 hours 1compartment NA NA Human Human +DTXSID4032619 Css NA 1.048 mg/L 3compartmentss NA 50% Human Human +DTXSID4032619 Css NA 9.273 mg/L 3compartmentss NA 95% Human Human +DTXSID4032619 Css NA 0.6612 mg/L PBTK NA 50% Human Human +DTXSID4032619 Css NA 5.589 mg/L PBTK NA 95% Human Human +DTXSID4032619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032619 Fup 0.0289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4032619 Vd NA 1.036 L/kg 1compartment NA NA Rat Human +DTXSID4032619 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4032619 TK.Half.Life NA 3.819 hours 1compartment NA NA Rat Human +DTXSID4032619 Css NA 0.1351 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032619 Css NA 1.003 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032619 Css NA 0.08219 mg/L PBTK NA 50% Rat Human +DTXSID4032619 Css NA 0.5879 mg/L PBTK NA 95% Rat Human DTXSID4032954 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4032954 Fup NA 0.5249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4032954 Vd NA 0.445 L/kg 1compartment NA NA Human Human DTXSID4032954 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4032954 TK.Half.Life NA 5.484 hours 1compartment NA NA Human Human -DTXSID4032954 Css NA 1.474 mg/L 3compartmentss NA 50% Human Human -DTXSID4032954 Css NA 8.184 mg/L 3compartmentss NA 95% Human Human -DTXSID4032954 Css NA 1.077 mg/L PBTK NA 50% Human Human -DTXSID4032954 Css NA 5.107 mg/L PBTK NA 95% Human Human +DTXSID4032954 Css NA 1.239 mg/L 3compartmentss NA 50% Human Human +DTXSID4032954 Css NA 6.843 mg/L 3compartmentss NA 95% Human Human +DTXSID4032954 Css NA 0.9088 mg/L PBTK NA 50% Human Human +DTXSID4032954 Css NA 4.238 mg/L PBTK NA 95% Human Human DTXSID4032954 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4032954 Fup NA 0.5249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4032954 Vd NA 0.4614 L/kg 1compartment NA NA Rat Human DTXSID4032954 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4032954 TK.Half.Life NA 1.938 hours 1compartment NA NA Rat Human -DTXSID4032954 Css NA 0.395 mg/L 3compartmentss NA 50% Rat Human -DTXSID4032954 Css NA 1.913 mg/L 3compartmentss NA 95% Rat Human -DTXSID4032954 Css NA 0.2757 mg/L PBTK NA 50% Rat Human -DTXSID4032954 Css NA 1.108 mg/L PBTK NA 95% Rat Human -DTXSID4033390 Clint NA 24.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4033390 Fup NA 0.0678 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4033390 Vd NA 1.434 L/kg 1compartment NA NA Human Human +DTXSID4032954 Css NA 0.0233 mg/L 3compartmentss NA 50% Rat Human +DTXSID4032954 Css NA 0.1746 mg/L 3compartmentss NA 95% Rat Human +DTXSID4032954 Css NA 0.01649 mg/L PBTK NA 50% Rat Human +DTXSID4032954 Css NA 0.1075 mg/L PBTK NA 95% Rat Human +DTXSID40332791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40332791 Fup 0.0635 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40332791 Vd NA 1.944 L/kg 1compartment NA NA Human Human +DTXSID40332791 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40332791 TK.Half.Life NA 8.716 hours 1compartment NA NA Human Human +DTXSID40332791 Css NA 0.5534 mg/L 3compartmentss NA 50% Human Human +DTXSID40332791 Css NA 3.832 mg/L 3compartmentss NA 95% Human Human +DTXSID40332791 Css NA 0.3667 mg/L PBTK NA 50% Human Human +DTXSID40332791 Css NA 2.437 mg/L PBTK NA 95% Human Human +DTXSID40332791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40332791 Fup 0.0635 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40332791 Vd NA 1.462 L/kg 1compartment NA NA Rat Human +DTXSID40332791 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40332791 TK.Half.Life NA 2.92 hours 1compartment NA NA Rat Human +DTXSID40332791 Css NA 0.07162 mg/L 3compartmentss NA 50% Rat Human +DTXSID40332791 Css NA 0.4071 mg/L 3compartmentss NA 95% Rat Human +DTXSID40332791 Css NA 0.0463 mg/L PBTK NA 50% Rat Human +DTXSID40332791 Css NA 0.2521 mg/L PBTK NA 95% Rat Human +DTXSID4033390 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4033390 Fup 0.097 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4033390 Vd NA 1.82 L/kg 1compartment NA NA Human Human DTXSID4033390 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4033390 TK.Half.Life NA 4.857 hours 1compartment NA NA Human Human -DTXSID4033390 Css NA 0.4334 mg/L 3compartmentss NA 50% Human Human -DTXSID4033390 Css NA 3.159 mg/L 3compartmentss NA 95% Human Human -DTXSID4033390 Css NA 0.2795 mg/L PBTK NA 50% Human Human -DTXSID4033390 Css NA 1.982 mg/L PBTK NA 95% Human Human -DTXSID4033390 Clint NA 24.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4033390 Fup NA 0.0678 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4033390 Vd NA 1.087 L/kg 1compartment NA NA Rat Human +DTXSID4033390 TK.Half.Life NA 5.767 hours 1compartment NA NA Human Human +DTXSID4033390 Css NA 0.35 mg/L 3compartmentss NA 50% Human Human +DTXSID4033390 Css NA 2.544 mg/L 3compartmentss NA 95% Human Human +DTXSID4033390 Css NA 0.2335 mg/L PBTK NA 50% Human Human +DTXSID4033390 Css NA 1.635 mg/L PBTK NA 95% Human Human +DTXSID4033390 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4033390 Fup 0.097 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4033390 Vd NA 1.381 L/kg 1compartment NA NA Rat Human DTXSID4033390 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4033390 TK.Half.Life NA 1.905 hours 1compartment NA NA Rat Human -DTXSID4033390 Css NA 0.2388 mg/L 3compartmentss NA 50% Rat Human -DTXSID4033390 Css NA 1.371 mg/L 3compartmentss NA 95% Rat Human -DTXSID4033390 Css NA 0.1454 mg/L PBTK NA 50% Rat Human -DTXSID4033390 Css NA 0.7986 mg/L PBTK NA 95% Rat Human -DTXSID4034102 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034102 Fup NA 0.064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034102 Vd NA 0.9028 L/kg 1compartment NA NA Human Human +DTXSID4033390 TK.Half.Life NA 2.036 hours 1compartment NA NA Rat Human +DTXSID4033390 Css NA 0.04508 mg/L 3compartmentss NA 50% Rat Human +DTXSID4033390 Css NA 0.2618 mg/L 3compartmentss NA 95% Rat Human +DTXSID4033390 Css NA 0.02965 mg/L PBTK NA 50% Rat Human +DTXSID4033390 Css NA 0.1641 mg/L PBTK NA 95% Rat Human +DTXSID40338233 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40338233 Fup 0.78 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40338233 Vd NA 0.9881 L/kg 1compartment NA NA Human Human +DTXSID40338233 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40338233 TK.Half.Life NA 0.7622 hours 1compartment NA NA Human Human +DTXSID40338233 Css NA 0.0202 mg/L 3compartmentss NA 50% Human Human +DTXSID40338233 Css NA 0.2386 mg/L 3compartmentss NA 95% Human Human +DTXSID40338233 Css NA 0.01697 mg/L PBTK NA 50% Human Human +DTXSID40338233 Css NA 0.169 mg/L PBTK NA 95% Human Human +DTXSID40338233 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40338233 Fup 0.78 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40338233 Vd NA 0.9613 L/kg 1compartment NA NA Rat Human +DTXSID40338233 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40338233 TK.Half.Life NA 0.3597 hours 1compartment NA NA Rat Human +DTXSID40338233 Css NA 0.0007132 mg/L 3compartmentss NA 50% Rat Human +DTXSID40338233 Css NA 0.009798 mg/L 3compartmentss NA 95% Rat Human +DTXSID40338233 Css NA 0.0006048 mg/L PBTK NA 50% Rat Human +DTXSID40338233 Css NA 0.006688 mg/L PBTK NA 95% Rat Human +DTXSID40340795 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40340795 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40340795 Vd NA 1.213 L/kg 1compartment NA NA Human Human +DTXSID40340795 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40340795 TK.Half.Life NA 2.395 hours 1compartment NA NA Human Human +DTXSID40340795 Css NA 0.1623 mg/L 3compartmentss NA 50% Human Human +DTXSID40340795 Css NA 1.209 mg/L 3compartmentss NA 95% Human Human +DTXSID40340795 Css NA 0.1114 mg/L PBTK NA 50% Human Human +DTXSID40340795 Css NA 0.7729 mg/L PBTK NA 95% Human Human +DTXSID40340795 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40340795 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40340795 Vd NA 0.9635 L/kg 1compartment NA NA Rat Human +DTXSID40340795 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40340795 TK.Half.Life NA 0.9996 hours 1compartment NA NA Rat Human +DTXSID40340795 Css NA 0.02082 mg/L 3compartmentss NA 50% Rat Human +DTXSID40340795 Css NA 0.1215 mg/L 3compartmentss NA 95% Rat Human +DTXSID40340795 Css NA 0.01408 mg/L PBTK NA 50% Rat Human +DTXSID40340795 Css NA 0.07673 mg/L PBTK NA 95% Rat Human +DTXSID4034102 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034102 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034102 Vd NA 1.983 L/kg 1compartment NA NA Human Human DTXSID4034102 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4034102 TK.Half.Life NA 1.51 hours 1compartment NA NA Human Human -DTXSID4034102 Css NA 0.1371 mg/L 3compartmentss NA 50% Human Human -DTXSID4034102 Css NA 1.127 mg/L 3compartmentss NA 95% Human Human -DTXSID4034102 Css NA 0.08616 mg/L PBTK NA 50% Human Human -DTXSID4034102 Css NA 0.6865 mg/L PBTK NA 95% Human Human -DTXSID4034102 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034102 Fup NA 0.064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034102 Vd NA 0.7011 L/kg 1compartment NA NA Rat Human +DTXSID4034102 TK.Half.Life NA 5.733 hours 1compartment NA NA Human Human +DTXSID4034102 Css NA 0.2958 mg/L 3compartmentss NA 50% Human Human +DTXSID4034102 Css NA 2.121 mg/L 3compartmentss NA 95% Human Human +DTXSID4034102 Css NA 0.202 mg/L PBTK NA 50% Human Human +DTXSID4034102 Css NA 1.357 mg/L PBTK NA 95% Human Human +DTXSID4034102 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034102 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034102 Vd NA 1.508 L/kg 1compartment NA NA Rat Human DTXSID4034102 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4034102 TK.Half.Life NA 0.6211 hours 1compartment NA NA Rat Human -DTXSID4034102 Css NA 0.07842 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034102 Css NA 0.5038 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034102 Css NA 0.04615 mg/L PBTK NA 50% Rat Human -DTXSID4034102 Css NA 0.2849 mg/L PBTK NA 95% Rat Human +DTXSID4034102 TK.Half.Life NA 1.927 hours 1compartment NA NA Rat Human +DTXSID4034102 Css NA 0.03821 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034102 Css NA 0.2149 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034102 Css NA 0.0258 mg/L PBTK NA 50% Rat Human +DTXSID4034102 Css NA 0.1376 mg/L PBTK NA 95% Rat Human DTXSID4034150 Clint 5.062 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4034150 Fup 0.1784 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4034150 Vd NA 21.65 L/kg 1compartment NA NA Human Human DTXSID4034150 Days.Css NA 11 Days PBTK NA NA Human Human DTXSID4034150 TK.Half.Life NA 73.74 hours 1compartment NA NA Human Human -DTXSID4034150 Css NA 0.0526 mg/L 3compartmentss NA 50% Human Human -DTXSID4034150 Css NA 0.4112 mg/L 3compartmentss NA 95% Human Human -DTXSID4034150 Css NA 0.2978 mg/L PBTK NA 50% Human Human -DTXSID4034150 Css NA 1.627 mg/L PBTK NA 95% Human Human +DTXSID4034150 Css NA 0.04967 mg/L 3compartmentss NA 50% Human Human +DTXSID4034150 Css NA 0.4093 mg/L 3compartmentss NA 95% Human Human +DTXSID4034150 Css NA 0.2817 mg/L PBTK NA 50% Human Human +DTXSID4034150 Css NA 1.635 mg/L PBTK NA 95% Human Human DTXSID4034150 Clint 5.062 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID4034150 Fup 0.1784 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4034150 Vd NA 24.8 L/kg 1compartment NA NA Rat Human DTXSID4034150 Days.Css NA 9 Days PBTK NA NA Rat Human DTXSID4034150 TK.Half.Life NA 27.22 hours 1compartment NA NA Rat Human -DTXSID4034150 Css NA 0.02028 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034150 Css NA 0.1204 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034150 Css NA 0.1365 mg/L PBTK NA 50% Rat Human -DTXSID4034150 Css NA 0.5623 mg/L PBTK NA 95% Rat Human +DTXSID4034150 Css NA 0.004322 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034150 Css NA 0.02663 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034150 Css NA 0.03034 mg/L PBTK NA 50% Rat Human +DTXSID4034150 Css NA 0.1274 mg/L PBTK NA 95% Rat Human DTXSID4034287 Clint 9.47 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4034287 Fup 0.069 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4034287 Vd NA 2.262 L/kg 1compartment NA NA Human Human -DTXSID4034287 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4034287 TK.Half.Life NA 22.42 hours 1compartment NA NA Human Human -DTXSID4034287 Css NA 1.148 mg/L 3compartmentss NA 50% Human Human -DTXSID4034287 Css NA 6.947 mg/L 3compartmentss NA 95% Human Human -DTXSID4034287 Css NA 0.7857 mg/L PBTK NA 50% Human Human -DTXSID4034287 Css NA 4.553 mg/L PBTK NA 95% Human Human +DTXSID4034287 Vd NA 2.446 L/kg 1compartment NA NA Human Human +DTXSID4034287 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4034287 TK.Half.Life NA 27.64 hours 1compartment NA NA Human Human +DTXSID4034287 Css NA 1.284 mg/L 3compartmentss NA 50% Human Human +DTXSID4034287 Css NA 7.533 mg/L 3compartmentss NA 95% Human Human +DTXSID4034287 Css NA 0.883 mg/L PBTK NA 50% Human Human +DTXSID4034287 Css NA 4.969 mg/L PBTK NA 95% Human Human DTXSID4034287 Clint 9.47 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4034287 Fup 0.069 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4034287 Vd NA 1.7 L/kg 1compartment NA NA Rat Human +DTXSID4034287 Vd NA 1.838 L/kg 1compartment NA NA Rat Human DTXSID4034287 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4034287 TK.Half.Life NA 6.359 hours 1compartment NA NA Rat Human -DTXSID4034287 Css NA 0.6258 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034287 Css NA 2.72 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034287 Css NA 0.4069 mg/L PBTK NA 50% Rat Human -DTXSID4034287 Css NA 1.711 mg/L PBTK NA 95% Rat Human +DTXSID4034287 TK.Half.Life NA 7.046 hours 1compartment NA NA Rat Human +DTXSID4034287 Css NA 0.1598 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034287 Css NA 0.728 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034287 Css NA 0.109 mg/L PBTK NA 50% Rat Human +DTXSID4034287 Css NA 0.4701 mg/L PBTK NA 95% Rat Human DTXSID4034364 Clint 3.107 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4034364 Fup 0.06084 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4034364 Vd NA 0.2472 L/kg 1compartment NA NA Human Human DTXSID4034364 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4034364 TK.Half.Life NA 4.384 hours 1compartment NA NA Human Human -DTXSID4034364 Css NA 3.158 mg/L 3compartmentss NA 50% Human Human -DTXSID4034364 Css NA 18.68 mg/L 3compartmentss NA 95% Human Human -DTXSID4034364 Css NA 1.904 mg/L PBTK NA 50% Human Human -DTXSID4034364 Css NA 10.97 mg/L PBTK NA 95% Human Human +DTXSID4034364 Css NA 2.73 mg/L 3compartmentss NA 50% Human Human +DTXSID4034364 Css NA 16.44 mg/L 3compartmentss NA 95% Human Human +DTXSID4034364 Css NA 1.634 mg/L PBTK NA 50% Human Human +DTXSID4034364 Css NA 9.696 mg/L PBTK NA 95% Human Human DTXSID4034364 Clint 3.107 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4034364 Fup 0.06084 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4034364 Vd NA 0.2461 L/kg 1compartment NA NA Rat Human DTXSID4034364 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4034364 TK.Half.Life NA 2.575 hours 1compartment NA NA Rat Human -DTXSID4034364 Css NA 1.567 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034364 Css NA 7.274 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034364 Css NA 0.8816 mg/L PBTK NA 50% Rat Human -DTXSID4034364 Css NA 3.985 mg/L PBTK NA 95% Rat Human -DTXSID4034497 Clint NA 13.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034497 Fup NA 0.0382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034497 Vd NA 2.43 L/kg 1compartment NA NA Human Human -DTXSID4034497 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4034497 TK.Half.Life NA 30.28 hours 1compartment NA NA Human Human -DTXSID4034497 Css NA 1.778 mg/L 3compartmentss NA 50% Human Human -DTXSID4034497 Css NA 12.04 mg/L 3compartmentss NA 95% Human Human -DTXSID4034497 Css NA 1.188 mg/L PBTK NA 50% Human Human -DTXSID4034497 Css NA 7.694 mg/L PBTK NA 95% Human Human -DTXSID4034497 Clint NA 13.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034497 Fup NA 0.0382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034497 Vd NA 1.818 L/kg 1compartment NA NA Rat Human +DTXSID4034364 Css NA 0.1153 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034364 Css NA 0.8426 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034364 Css NA 0.06648 mg/L PBTK NA 50% Rat Human +DTXSID4034364 Css NA 0.4782 mg/L PBTK NA 95% Rat Human +DTXSID4034497 Clint 16.7 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID4034497 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034497 Vd NA 2.281 L/kg 1compartment NA NA Human Human +DTXSID4034497 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4034497 TK.Half.Life NA 25.48 hours 1compartment NA NA Human Human +DTXSID4034497 Css NA 1.594 mg/L 3compartmentss NA 50% Human Human +DTXSID4034497 Css NA 12.05 mg/L 3compartmentss NA 95% Human Human +DTXSID4034497 Css NA 1.05 mg/L PBTK NA 50% Human Human +DTXSID4034497 Css NA 7.547 mg/L PBTK NA 95% Human Human +DTXSID4034497 Clint 16.7 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human +DTXSID4034497 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034497 Vd NA 1.702 L/kg 1compartment NA NA Rat Human DTXSID4034497 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4034497 TK.Half.Life NA 7.803 hours 1compartment NA NA Rat Human -DTXSID4034497 Css NA 0.9712 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034497 Css NA 5.418 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034497 Css NA 0.6148 mg/L PBTK NA 50% Rat Human -DTXSID4034497 Css NA 3.229 mg/L PBTK NA 95% Rat Human +DTXSID4034497 TK.Half.Life NA 7.163 hours 1compartment NA NA Rat Human +DTXSID4034497 Css NA 0.2025 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034497 Css NA 1.258 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034497 Css NA 0.1301 mg/L PBTK NA 50% Rat Human +DTXSID4034497 Css NA 0.78 mg/L PBTK NA 95% Rat Human DTXSID4034528 Clint 3.442 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4034528 Fup 0.00648 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID4034528 Vd NA 0.3329 L/kg 1compartment NA NA Human Human -DTXSID4034528 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID4034528 TK.Half.Life NA 45.19 hours 1compartment NA NA Human Human -DTXSID4034528 Css NA 25.12 mg/L 3compartmentss NA 50% Human Human -DTXSID4034528 Css NA 204.6 mg/L 3compartmentss NA 95% Human Human -DTXSID4034528 Css NA 14.72 mg/L PBTK NA 50% Human Human -DTXSID4034528 Css NA 119.6 mg/L PBTK NA 95% Human Human +DTXSID4034528 Vd NA 0.4518 L/kg 1compartment NA NA Human Human +DTXSID4034528 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID4034528 TK.Half.Life NA 58.79 hours 1compartment NA NA Human Human +DTXSID4034528 Css NA 22.85 mg/L 3compartmentss NA 50% Human Human +DTXSID4034528 Css NA 178.4 mg/L 3compartmentss NA 95% Human Human +DTXSID4034528 Css NA 13.5 mg/L PBTK NA 50% Human Human +DTXSID4034528 Css NA 103.1 mg/L PBTK NA 95% Human Human DTXSID4034528 Clint 3.442 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4034528 Fup 0.00648 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID4034528 Vd NA 0.2678 L/kg 1compartment NA NA Rat Human -DTXSID4034528 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4034528 TK.Half.Life NA 22.05 hours 1compartment NA NA Rat Human -DTXSID4034528 Css NA 12.89 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034528 Css NA 84.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034528 Css NA 7.044 mg/L PBTK NA 50% Rat Human -DTXSID4034528 Css NA 45.47 mg/L PBTK NA 95% Rat Human -DTXSID4034576 Clint NA 0.1749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034576 Fup NA 0.2383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034576 Vd NA 1.305 L/kg 1compartment NA NA Human Human -DTXSID4034576 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4034576 TK.Half.Life NA 33.45 hours 1compartment NA NA Human Human -DTXSID4034576 Css NA 2.851 mg/L 3compartmentss NA 50% Human Human -DTXSID4034576 Css NA 10.37 mg/L 3compartmentss NA 95% Human Human -DTXSID4034576 Css NA 2.056 mg/L PBTK NA 50% Human Human -DTXSID4034576 Css NA 6.716 mg/L PBTK NA 95% Human Human -DTXSID4034576 Clint NA 0.1749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034576 Fup NA 0.2383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034576 Vd NA 1.036 L/kg 1compartment NA NA Rat Human -DTXSID4034576 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4034576 TK.Half.Life NA 8.795 hours 1compartment NA NA Rat Human -DTXSID4034576 Css NA 0.9088 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034576 Css NA 2.775 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034576 Css NA 0.6256 mg/L PBTK NA 50% Rat Human -DTXSID4034576 Css NA 1.658 mg/L PBTK NA 95% Rat Human -DTXSID4034601 Clint NA 46.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034601 Fup NA 0.0667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034601 Vd NA 3.11 L/kg 1compartment NA NA Human Human -DTXSID4034601 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4034601 TK.Half.Life NA 25.28 hours 1compartment NA NA Human Human -DTXSID4034601 Css NA 0.902 mg/L 3compartmentss NA 50% Human Human -DTXSID4034601 Css NA 5.668 mg/L 3compartmentss NA 95% Human Human -DTXSID4034601 Css NA 0.6317 mg/L PBTK NA 50% Human Human -DTXSID4034601 Css NA 3.891 mg/L PBTK NA 95% Human Human -DTXSID4034601 Clint NA 46.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034601 Fup NA 0.0667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034601 Vd NA 2.344 L/kg 1compartment NA NA Rat Human -DTXSID4034601 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4034601 TK.Half.Life NA 4.004 hours 1compartment NA NA Rat Human -DTXSID4034601 Css NA 0.502 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034601 Css NA 2.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034601 Css NA 0.3378 mg/L PBTK NA 50% Rat Human -DTXSID4034601 Css NA 1.827 mg/L PBTK NA 95% Rat Human +DTXSID4034528 Vd NA 0.3467 L/kg 1compartment NA NA Rat Human +DTXSID4034528 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID4034528 TK.Half.Life NA 27.21 hours 1compartment NA NA Rat Human +DTXSID4034528 Css NA 2.054 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034528 Css NA 13.58 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034528 Css NA 1.162 mg/L PBTK NA 50% Rat Human +DTXSID4034528 Css NA 7.609 mg/L PBTK NA 95% Rat Human +DTXSID40345609 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40345609 Fup 0.0202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40345609 Vd NA 3.123 L/kg 1compartment NA NA Human Human +DTXSID40345609 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID40345609 TK.Half.Life NA 93.87 hours 1compartment NA NA Human Human +DTXSID40345609 Css NA 3.412 mg/L 3compartmentss NA 50% Human Human +DTXSID40345609 Css NA 20.04 mg/L 3compartmentss NA 95% Human Human +DTXSID40345609 Css NA 2.369 mg/L PBTK NA 50% Human Human +DTXSID40345609 Css NA 13.71 mg/L PBTK NA 95% Human Human +DTXSID40345609 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40345609 Fup 0.0202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40345609 Vd NA 2.339 L/kg 1compartment NA NA Rat Human +DTXSID40345609 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID40345609 TK.Half.Life NA 12.53 hours 1compartment NA NA Rat Human +DTXSID40345609 Css NA 0.4499 mg/L 3compartmentss NA 50% Rat Human +DTXSID40345609 Css NA 2.119 mg/L 3compartmentss NA 95% Rat Human +DTXSID40345609 Css NA 0.3094 mg/L PBTK NA 50% Rat Human +DTXSID40345609 Css NA 1.478 mg/L PBTK NA 95% Rat Human +DTXSID4034576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034576 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034576 Vd NA 0.9951 L/kg 1compartment NA NA Human Human +DTXSID4034576 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4034576 TK.Half.Life NA 2.287 hours 1compartment NA NA Human Human +DTXSID4034576 Css NA 0.2239 mg/L 3compartmentss NA 50% Human Human +DTXSID4034576 Css NA 1.795 mg/L 3compartmentss NA 95% Human Human +DTXSID4034576 Css NA 0.147 mg/L PBTK NA 50% Human Human +DTXSID4034576 Css NA 1.117 mg/L PBTK NA 95% Human Human +DTXSID4034576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034576 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034576 Vd NA 0.781 L/kg 1compartment NA NA Rat Human +DTXSID4034576 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4034576 TK.Half.Life NA 0.9807 hours 1compartment NA NA Rat Human +DTXSID4034576 Css NA 0.02909 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034576 Css NA 0.1758 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034576 Css NA 0.01857 mg/L PBTK NA 50% Rat Human +DTXSID4034576 Css NA 0.1068 mg/L PBTK NA 95% Rat Human +DTXSID4034601 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034601 Fup 0.0919 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034601 Vd NA 3.131 L/kg 1compartment NA NA Human Human +DTXSID4034601 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4034601 TK.Half.Life NA 51.34 hours 1compartment NA NA Human Human +DTXSID4034601 Css NA 1.872 mg/L 3compartmentss NA 50% Human Human +DTXSID4034601 Css NA 11.76 mg/L 3compartmentss NA 95% Human Human +DTXSID4034601 Css NA 1.326 mg/L PBTK NA 50% Human Human +DTXSID4034601 Css NA 8.027 mg/L PBTK NA 95% Human Human +DTXSID4034601 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034601 Fup 0.0919 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034601 Vd NA 2.36 L/kg 1compartment NA NA Rat Human +DTXSID4034601 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID4034601 TK.Half.Life NA 7.439 hours 1compartment NA NA Rat Human +DTXSID4034601 Css NA 0.244 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034601 Css NA 1.331 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034601 Css NA 0.1707 mg/L PBTK NA 50% Rat Human +DTXSID4034601 Css NA 0.909 mg/L PBTK NA 95% Rat Human DTXSID4034609 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4034609 Fup 0.0461 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID4034609 Vd NA 2.32 L/kg 1compartment NA NA Human Human -DTXSID4034609 Days.Css NA 213 Days PBTK NA NA Human Human +DTXSID4034609 Days.Css NA 214 Days PBTK NA NA Human Human DTXSID4034609 TK.Half.Life NA 849 hours 1compartment NA NA Human Human -DTXSID4034609 Css NA 49.76 mg/L 3compartmentss NA 50% Human Human -DTXSID4034609 Css NA 163 mg/L 3compartmentss NA 95% Human Human -DTXSID4034609 Css NA 33.11 mg/L PBTK NA 50% Human Human -DTXSID4034609 Css NA 99.53 mg/L PBTK NA 95% Human Human +DTXSID4034609 Css NA 48.36 mg/L 3compartmentss NA 50% Human Human +DTXSID4034609 Css NA 163.5 mg/L 3compartmentss NA 95% Human Human +DTXSID4034609 Css NA 32.11 mg/L PBTK NA 50% Human Human +DTXSID4034609 Css NA 101.3 mg/L PBTK NA 95% Human Human DTXSID4034609 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4034609 Fup 0.0461 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID4034609 Vd NA 1.733 L/kg 1compartment NA NA Rat Human -DTXSID4034609 Days.Css NA 51 Days PBTK NA NA Rat Human +DTXSID4034609 Days.Css NA 52 Days PBTK NA NA Rat Human DTXSID4034609 TK.Half.Life NA 114.6 hours 1compartment NA NA Rat Human -DTXSID4034609 Css NA 13.69 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034609 Css NA 37.62 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034609 Css NA 8.629 mg/L PBTK NA 50% Rat Human -DTXSID4034609 Css NA 21.67 mg/L PBTK NA 95% Rat Human +DTXSID4034609 Css NA 3.085 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034609 Css NA 8.355 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034609 Css NA 2.014 mg/L PBTK NA 50% Rat Human +DTXSID4034609 Css NA 4.989 mg/L PBTK NA 95% Rat Human DTXSID4034653 Clint 16.22 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4034653 Fup 0.041 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4034653 Vd NA 2.482 L/kg 1compartment NA NA Human Human DTXSID4034653 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID4034653 TK.Half.Life NA 25.5 hours 1compartment NA NA Human Human -DTXSID4034653 Css NA 1.536 mg/L 3compartmentss NA 50% Human Human -DTXSID4034653 Css NA 10.52 mg/L 3compartmentss NA 95% Human Human -DTXSID4034653 Css NA 0.9652 mg/L PBTK NA 50% Human Human -DTXSID4034653 Css NA 6.444 mg/L PBTK NA 95% Human Human +DTXSID4034653 Css NA 1.256 mg/L 3compartmentss NA 50% Human Human +DTXSID4034653 Css NA 8.363 mg/L 3compartmentss NA 95% Human Human +DTXSID4034653 Css NA 0.9485 mg/L PBTK NA 50% Human Human +DTXSID4034653 Css NA 6.316 mg/L PBTK NA 95% Human Human DTXSID4034653 Clint 46.16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4034653 Fup 0.06856 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID4034653 Vd NA 2.035 L/kg 1compartment NA NA Rat Rat DTXSID4034653 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID4034653 TK.Half.Life NA 2.334 hours 1compartment NA NA Rat Rat -DTXSID4034653 Css NA 0.2598 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4034653 Css NA 1.363 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4034653 Css NA 0.1506 mg/L PBTK NA 50% Rat Rat -DTXSID4034653 Css NA 0.7812 mg/L PBTK NA 95% Rat Rat -DTXSID4034788 Clint NA 57.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034788 Fup NA 0.0752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034788 Vd NA 0.2376 L/kg 1compartment NA NA Human Human +DTXSID4034653 Css NA 0.04504 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4034653 Css NA 0.2605 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4034653 Css NA 0.03523 mg/L PBTK NA 50% Rat Rat +DTXSID4034653 Css NA 0.2038 mg/L PBTK NA 95% Rat Rat +DTXSID4034788 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034788 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034788 Vd NA 0.2782 L/kg 1compartment NA NA Human Human DTXSID4034788 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4034788 TK.Half.Life NA 0.4292 hours 1compartment NA NA Human Human -DTXSID4034788 Css NA 0.1605 mg/L 3compartmentss NA 50% Human Human -DTXSID4034788 Css NA 1.318 mg/L 3compartmentss NA 95% Human Human -DTXSID4034788 Css NA 0.09685 mg/L PBTK NA 50% Human Human -DTXSID4034788 Css NA 0.7829 mg/L PBTK NA 95% Human Human -DTXSID4034788 Clint NA 57.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034788 Fup NA 0.0752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034788 Vd NA 0.2355 L/kg 1compartment NA NA Rat Human +DTXSID4034788 TK.Half.Life NA 1.612 hours 1compartment NA NA Human Human +DTXSID4034788 Css NA 0.4334 mg/L 3compartmentss NA 50% Human Human +DTXSID4034788 Css NA 3.401 mg/L 3compartmentss NA 95% Human Human +DTXSID4034788 Css NA 0.2712 mg/L PBTK NA 50% Human Human +DTXSID4034788 Css NA 2.049 mg/L PBTK NA 95% Human Human +DTXSID4034788 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034788 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034788 Vd NA 0.2757 L/kg 1compartment NA NA Rat Human DTXSID4034788 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4034788 TK.Half.Life NA 0.2381 hours 1compartment NA NA Rat Human -DTXSID4034788 Css NA 0.09385 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034788 Css NA 0.5853 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034788 Css NA 0.05293 mg/L PBTK NA 50% Rat Human -DTXSID4034788 Css NA 0.3283 mg/L PBTK NA 95% Rat Human -DTXSID4034869 Clint NA 4.433 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034869 Fup NA 0.0159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4034869 Vd NA 0.3533 L/kg 1compartment NA NA Human Human -DTXSID4034869 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4034869 TK.Half.Life NA 16.64 hours 1compartment NA NA Human Human -DTXSID4034869 Css NA 8.593 mg/L 3compartmentss NA 50% Human Human -DTXSID4034869 Css NA 70.36 mg/L 3compartmentss NA 95% Human Human -DTXSID4034869 Css NA 5.107 mg/L PBTK NA 50% Human Human -DTXSID4034869 Css NA 40.97 mg/L PBTK NA 95% Human Human -DTXSID4034869 Clint NA 4.433 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034869 Fup NA 0.0159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4034869 Vd NA 0.3025 L/kg 1compartment NA NA Rat Human +DTXSID4034788 TK.Half.Life NA 0.969 hours 1compartment NA NA Rat Human +DTXSID4034788 Css NA 0.004416 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034788 Css NA 0.02934 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034788 Css NA 0.002579 mg/L PBTK NA 50% Rat Human +DTXSID4034788 Css NA 0.01642 mg/L PBTK NA 95% Rat Human +DTXSID4034869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034869 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4034869 Vd NA 3.451 L/kg 1compartment NA NA Human Human +DTXSID4034869 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4034869 TK.Half.Life NA 7.761 hours 1compartment NA NA Human Human +DTXSID4034869 Css NA 0.1756 mg/L 3compartmentss NA 50% Human Human +DTXSID4034869 Css NA 1.354 mg/L 3compartmentss NA 95% Human Human +DTXSID4034869 Css NA 0.1476 mg/L PBTK NA 50% Human Human +DTXSID4034869 Css NA 1.024 mg/L PBTK NA 95% Human Human +DTXSID4034869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034869 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4034869 Vd NA 2.962 L/kg 1compartment NA NA Rat Human DTXSID4034869 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4034869 TK.Half.Life NA 8.803 hours 1compartment NA NA Rat Human -DTXSID4034869 Css NA 4.564 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034869 Css NA 27.82 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034869 Css NA 2.518 mg/L PBTK NA 50% Rat Human -DTXSID4034869 Css NA 15.12 mg/L PBTK NA 95% Rat Human +DTXSID4034869 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human +DTXSID4034869 Css NA 0.02241 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034869 Css NA 0.1292 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034869 Css NA 0.01919 mg/L PBTK NA 50% Rat Human +DTXSID4034869 Css NA 0.1015 mg/L PBTK NA 95% Rat Human DTXSID4034948 Clint 22.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4034948 Fup 0.03378 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4034948 Vd NA 2.758 L/kg 1compartment NA NA Human Human DTXSID4034948 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID4034948 TK.Half.Life NA 30.56 hours 1compartment NA NA Human Human -DTXSID4034948 Css NA 1.442 mg/L 3compartmentss NA 50% Human Human -DTXSID4034948 Css NA 9.497 mg/L 3compartmentss NA 95% Human Human -DTXSID4034948 Css NA 0.9784 mg/L PBTK NA 50% Human Human -DTXSID4034948 Css NA 6.136 mg/L PBTK NA 95% Human Human +DTXSID4034948 Css NA 1.408 mg/L 3compartmentss NA 50% Human Human +DTXSID4034948 Css NA 9.466 mg/L 3compartmentss NA 95% Human Human +DTXSID4034948 Css NA 0.9534 mg/L PBTK NA 50% Human Human +DTXSID4034948 Css NA 6.187 mg/L PBTK NA 95% Human Human DTXSID4034948 Clint 22.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4034948 Fup 0.03378 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4034948 Vd NA 2.065 L/kg 1compartment NA NA Rat Human DTXSID4034948 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID4034948 TK.Half.Life NA 6.324 hours 1compartment NA NA Rat Human -DTXSID4034948 Css NA 0.8079 mg/L 3compartmentss NA 50% Rat Human -DTXSID4034948 Css NA 4.238 mg/L 3compartmentss NA 95% Rat Human -DTXSID4034948 Css NA 0.519 mg/L PBTK NA 50% Rat Human -DTXSID4034948 Css NA 2.642 mg/L PBTK NA 95% Rat Human -DTXSID4035209 Clint NA 0.005042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4035209 Fup NA 0.9194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4035209 Vd NA 0.7074 L/kg 1compartment NA NA Human Human +DTXSID4034948 Css NA 0.1822 mg/L 3compartmentss NA 50% Rat Human +DTXSID4034948 Css NA 1.024 mg/L 3compartmentss NA 95% Rat Human +DTXSID4034948 Css NA 0.1214 mg/L PBTK NA 50% Rat Human +DTXSID4034948 Css NA 0.6657 mg/L PBTK NA 95% Rat Human +DTXSID40351068 Clint 77.62 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40351068 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40351068 Vd NA 1.426 L/kg 1compartment NA NA Human Human +DTXSID40351068 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40351068 TK.Half.Life NA 4.037 hours 1compartment NA NA Human Human +DTXSID40351068 Css NA 0.3334 mg/L 3compartmentss NA 50% Human Human +DTXSID40351068 Css NA 3.157 mg/L 3compartmentss NA 95% Human Human +DTXSID40351068 Css NA 0.2094 mg/L PBTK NA 50% Human Human +DTXSID40351068 Css NA 1.919 mg/L PBTK NA 95% Human Human +DTXSID40351068 Clint 77.62 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40351068 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40351068 Vd NA 1.061 L/kg 1compartment NA NA Rat Human +DTXSID40351068 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40351068 TK.Half.Life NA 1.541 hours 1compartment NA NA Rat Human +DTXSID40351068 Css NA 0.04384 mg/L 3compartmentss NA 50% Rat Human +DTXSID40351068 Css NA 0.3362 mg/L 3compartmentss NA 95% Rat Human +DTXSID40351068 Css NA 0.02662 mg/L PBTK NA 50% Rat Human +DTXSID40351068 Css NA 0.1971 mg/L PBTK NA 95% Rat Human +DTXSID4035209 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4035209 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4035209 Vd NA 0.5437 L/kg 1compartment NA NA Human Human DTXSID4035209 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4035209 TK.Half.Life NA 4.937 hours 1compartment NA NA Human Human -DTXSID4035209 Css NA 0.9169 mg/L 3compartmentss NA 50% Human Human -DTXSID4035209 Css NA 5.276 mg/L 3compartmentss NA 95% Human Human -DTXSID4035209 Css NA 0.7496 mg/L PBTK NA 50% Human Human -DTXSID4035209 Css NA 3.385 mg/L PBTK NA 95% Human Human -DTXSID4035209 Clint NA 0.005042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4035209 Fup NA 0.9194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4035209 Vd NA 0.7463 L/kg 1compartment NA NA Rat Human +DTXSID4035209 TK.Half.Life NA 5.786 hours 1compartment NA NA Human Human +DTXSID4035209 Css NA 1.228 mg/L 3compartmentss NA 50% Human Human +DTXSID4035209 Css NA 8.063 mg/L 3compartmentss NA 95% Human Human +DTXSID4035209 Css NA 0.9364 mg/L PBTK NA 50% Human Human +DTXSID4035209 Css NA 4.991 mg/L PBTK NA 95% Human Human +DTXSID4035209 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4035209 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4035209 Vd NA 0.5753 L/kg 1compartment NA NA Rat Human DTXSID4035209 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4035209 TK.Half.Life NA 1.782 hours 1compartment NA NA Rat Human -DTXSID4035209 Css NA 0.2352 mg/L 3compartmentss NA 50% Rat Human -DTXSID4035209 Css NA 1.266 mg/L 3compartmentss NA 95% Rat Human -DTXSID4035209 Css NA 0.1867 mg/L PBTK NA 50% Rat Human -DTXSID4035209 Css NA 0.7627 mg/L PBTK NA 95% Rat Human -DTXSID4035542 Clint NA 125.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4035542 Fup NA 0.273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4035542 Vd NA 3.14 L/kg 1compartment NA NA Human Human -DTXSID4035542 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4035542 TK.Half.Life NA 15.05 hours 1compartment NA NA Human Human -DTXSID4035542 Css NA 0.4928 mg/L 3compartmentss NA 50% Human Human -DTXSID4035542 Css NA 3.234 mg/L 3compartmentss NA 95% Human Human -DTXSID4035542 Css NA 0.3444 mg/L PBTK NA 50% Human Human -DTXSID4035542 Css NA 2.168 mg/L PBTK NA 95% Human Human -DTXSID4035542 Clint NA 125.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4035542 Fup NA 0.273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4035542 Vd NA 2.355 L/kg 1compartment NA NA Rat Human -DTXSID4035542 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4035542 TK.Half.Life NA 2.421 hours 1compartment NA NA Rat Human -DTXSID4035542 Css NA 0.2745 mg/L 3compartmentss NA 50% Rat Human -DTXSID4035542 Css NA 1.508 mg/L 3compartmentss NA 95% Rat Human -DTXSID4035542 Css NA 0.1832 mg/L PBTK NA 50% Rat Human -DTXSID4035542 Css NA 0.9711 mg/L PBTK NA 95% Rat Human -DTXSID4035592 Clint NA 6.028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4035592 Fup NA 0.0258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4035592 Vd NA 3.225 L/kg 1compartment NA NA Human Human -DTXSID4035592 Days.Css NA 75 Days PBTK NA NA Human Human -DTXSID4035592 TK.Half.Life NA 342.1 hours 1compartment NA NA Human Human -DTXSID4035592 Css NA 12.46 mg/L 3compartmentss NA 50% Human Human -DTXSID4035592 Css NA 69.1 mg/L 3compartmentss NA 95% Human Human -DTXSID4035592 Css NA 8.77 mg/L PBTK NA 50% Human Human -DTXSID4035592 Css NA 47.44 mg/L PBTK NA 95% Human Human -DTXSID4035592 Clint NA 6.028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4035592 Fup NA 0.0258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4035592 Vd NA 2.419 L/kg 1compartment NA NA Rat Human -DTXSID4035592 Days.Css NA 41 Days PBTK NA NA Rat Human -DTXSID4035592 TK.Half.Life NA 44.12 hours 1compartment NA NA Rat Human -DTXSID4035592 Css NA 7.054 mg/L 3compartmentss NA 50% Rat Human -DTXSID4035592 Css NA 29.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID4035592 Css NA 4.737 mg/L PBTK NA 50% Rat Human -DTXSID4035592 Css NA 19.63 mg/L PBTK NA 95% Rat Human -DTXSID4035708 Clint NA 20.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4035708 Fup NA 0.464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4035708 Vd NA 1.445 L/kg 1compartment NA NA Human Human -DTXSID4035708 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4035708 TK.Half.Life NA 1.548 hours 1compartment NA NA Human Human -DTXSID4035708 Css NA 0.05033 mg/L 3compartmentss NA 50% Human Human -DTXSID4035708 Css NA 0.4017 mg/L 3compartmentss NA 95% Human Human -DTXSID4035708 Css NA 0.04118 mg/L PBTK NA 50% Human Human -DTXSID4035708 Css NA 0.2888 mg/L PBTK NA 95% Human Human -DTXSID4035708 Clint NA 20.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4035708 Fup NA 0.464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4035708 Vd NA 1.219 L/kg 1compartment NA NA Rat Human -DTXSID4035708 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4035708 TK.Half.Life NA 0.6359 hours 1compartment NA NA Rat Human -DTXSID4035708 Css NA 0.02639 mg/L 3compartmentss NA 50% Rat Human -DTXSID4035708 Css NA 0.1644 mg/L 3compartmentss NA 95% Rat Human -DTXSID4035708 Css NA 0.02108 mg/L PBTK NA 50% Rat Human -DTXSID4035708 Css NA 0.1121 mg/L PBTK NA 95% Rat Human -DTXSID4036229 Clint NA 12.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4036229 Fup NA 0.0752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4036229 Vd NA 0.3127 L/kg 1compartment NA NA Human Human -DTXSID4036229 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4036229 TK.Half.Life NA 1.508 hours 1compartment NA NA Human Human -DTXSID4036229 Css NA 0.702 mg/L 3compartmentss NA 50% Human Human -DTXSID4036229 Css NA 5.188 mg/L 3compartmentss NA 95% Human Human -DTXSID4036229 Css NA 0.4284 mg/L PBTK NA 50% Human Human -DTXSID4036229 Css NA 3.076 mg/L PBTK NA 95% Human Human -DTXSID4036229 Clint NA 12.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4036229 Fup NA 0.0752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4036229 Vd NA 0.2898 L/kg 1compartment NA NA Rat Human +DTXSID4035209 TK.Half.Life NA 2.087 hours 1compartment NA NA Rat Human +DTXSID4035209 Css NA 0.07552 mg/L 3compartmentss NA 50% Rat Human +DTXSID4035209 Css NA 0.4659 mg/L 3compartmentss NA 95% Rat Human +DTXSID4035209 Css NA 0.05723 mg/L PBTK NA 50% Rat Human +DTXSID4035209 Css NA 0.2793 mg/L PBTK NA 95% Rat Human +DTXSID4035839 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4035839 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4035839 Vd NA 0.9858 L/kg 1compartment NA NA Human Human +DTXSID4035839 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4035839 TK.Half.Life NA 13.73 hours 1compartment NA NA Human Human +DTXSID4035839 Css NA 1.414 mg/L 3compartmentss NA 50% Human Human +DTXSID4035839 Css NA 7.158 mg/L 3compartmentss NA 95% Human Human +DTXSID4035839 Css NA 1.146 mg/L PBTK NA 50% Human Human +DTXSID4035839 Css NA 4.654 mg/L PBTK NA 95% Human Human +DTXSID4035839 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4035839 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4035839 Vd NA 0.8998 L/kg 1compartment NA NA Rat Human +DTXSID4035839 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4035839 TK.Half.Life NA 4.109 hours 1compartment NA NA Rat Human +DTXSID4035839 Css NA 0.08835 mg/L 3compartmentss NA 50% Rat Human +DTXSID4035839 Css NA 0.4059 mg/L 3compartmentss NA 95% Rat Human +DTXSID4035839 Css NA 0.07137 mg/L PBTK NA 50% Rat Human +DTXSID4035839 Css NA 0.2541 mg/L PBTK NA 95% Rat Human +DTXSID4036229 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4036229 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4036229 Vd NA 0.9489 L/kg 1compartment NA NA Human Human +DTXSID4036229 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4036229 TK.Half.Life NA 30.58 hours 1compartment NA NA Human Human +DTXSID4036229 Css NA 3.578 mg/L 3compartmentss NA 50% Human Human +DTXSID4036229 Css NA 12.86 mg/L 3compartmentss NA 95% Human Human +DTXSID4036229 Css NA 2.537 mg/L PBTK NA 50% Human Human +DTXSID4036229 Css NA 8.2 mg/L PBTK NA 95% Human Human +DTXSID4036229 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4036229 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4036229 Vd NA 0.811 L/kg 1compartment NA NA Rat Human DTXSID4036229 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4036229 TK.Half.Life NA 0.867 hours 1compartment NA NA Rat Human -DTXSID4036229 Css NA 0.3975 mg/L 3compartmentss NA 50% Rat Human -DTXSID4036229 Css NA 2.103 mg/L 3compartmentss NA 95% Rat Human -DTXSID4036229 Css NA 0.2268 mg/L PBTK NA 50% Rat Human -DTXSID4036229 Css NA 1.176 mg/L PBTK NA 95% Rat Human -DTXSID4036489 Clint NA 17.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4036489 Fup NA 0.0718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4036489 Vd NA 1.942 L/kg 1compartment NA NA Human Human +DTXSID4036229 TK.Half.Life NA 8.399 hours 1compartment NA NA Rat Human +DTXSID4036229 Css NA 0.2304 mg/L 3compartmentss NA 50% Rat Human +DTXSID4036229 Css NA 0.7073 mg/L 3compartmentss NA 95% Rat Human +DTXSID4036229 Css NA 0.1613 mg/L PBTK NA 50% Rat Human +DTXSID4036229 Css NA 0.4328 mg/L PBTK NA 95% Rat Human +DTXSID4036435 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4036435 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4036435 Vd NA 3.092 L/kg 1compartment NA NA Human Human +DTXSID4036435 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4036435 TK.Half.Life NA 22.11 hours 1compartment NA NA Human Human +DTXSID4036435 Css NA 0.7658 mg/L 3compartmentss NA 50% Human Human +DTXSID4036435 Css NA 4.618 mg/L 3compartmentss NA 95% Human Human +DTXSID4036435 Css NA 0.5466 mg/L PBTK NA 50% Human Human +DTXSID4036435 Css NA 3.238 mg/L PBTK NA 95% Human Human +DTXSID4036435 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4036435 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4036435 Vd NA 2.358 L/kg 1compartment NA NA Rat Human +DTXSID4036435 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4036435 TK.Half.Life NA 3.892 hours 1compartment NA NA Rat Human +DTXSID4036435 Css NA 0.09564 mg/L 3compartmentss NA 50% Rat Human +DTXSID4036435 Css NA 0.4888 mg/L 3compartmentss NA 95% Rat Human +DTXSID4036435 Css NA 0.06842 mg/L PBTK NA 50% Rat Human +DTXSID4036435 Css NA 0.3456 mg/L PBTK NA 95% Rat Human +DTXSID4036489 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4036489 Fup 0.0876 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4036489 Vd NA 2.077 L/kg 1compartment NA NA Human Human DTXSID4036489 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4036489 TK.Half.Life NA 9.406 hours 1compartment NA NA Human Human -DTXSID4036489 Css NA 0.6186 mg/L 3compartmentss NA 50% Human Human -DTXSID4036489 Css NA 4.05 mg/L 3compartmentss NA 95% Human Human -DTXSID4036489 Css NA 0.41 mg/L PBTK NA 50% Human Human -DTXSID4036489 Css NA 2.573 mg/L PBTK NA 95% Human Human -DTXSID4036489 Clint NA 17.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4036489 Fup NA 0.0718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4036489 Vd NA 1.463 L/kg 1compartment NA NA Rat Human +DTXSID4036489 TK.Half.Life NA 7.807 hours 1compartment NA NA Human Human +DTXSID4036489 Css NA 0.4268 mg/L 3compartmentss NA 50% Human Human +DTXSID4036489 Css NA 2.944 mg/L 3compartmentss NA 95% Human Human +DTXSID4036489 Css NA 0.2879 mg/L PBTK NA 50% Human Human +DTXSID4036489 Css NA 1.916 mg/L PBTK NA 95% Human Human +DTXSID4036489 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4036489 Fup 0.0876 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4036489 Vd NA 1.568 L/kg 1compartment NA NA Rat Human DTXSID4036489 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4036489 TK.Half.Life NA 3.152 hours 1compartment NA NA Rat Human -DTXSID4036489 Css NA 0.3373 mg/L 3compartmentss NA 50% Rat Human -DTXSID4036489 Css NA 1.772 mg/L 3compartmentss NA 95% Rat Human -DTXSID4036489 Css NA 0.2122 mg/L PBTK NA 50% Rat Human -DTXSID4036489 Css NA 1.05 mg/L PBTK NA 95% Rat Human -DTXSID4036514 Clint NA 34.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4036514 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4036514 Vd NA 2.998 L/kg 1compartment NA NA Human Human -DTXSID4036514 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4036514 TK.Half.Life NA 38.57 hours 1compartment NA NA Human Human -DTXSID4036514 Css NA 1.597 mg/L 3compartmentss NA 50% Human Human -DTXSID4036514 Css NA 10.5 mg/L 3compartmentss NA 95% Human Human -DTXSID4036514 Css NA 1.091 mg/L PBTK NA 50% Human Human -DTXSID4036514 Css NA 6.833 mg/L PBTK NA 95% Human Human -DTXSID4036514 Clint NA 34.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4036514 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4036514 Vd NA 2.244 L/kg 1compartment NA NA Rat Human -DTXSID4036514 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4036514 TK.Half.Life NA 6.307 hours 1compartment NA NA Rat Human -DTXSID4036514 Css NA 0.8962 mg/L 3compartmentss NA 50% Rat Human -DTXSID4036514 Css NA 4.718 mg/L 3compartmentss NA 95% Rat Human -DTXSID4036514 Css NA 0.589 mg/L PBTK NA 50% Rat Human -DTXSID4036514 Css NA 3.03 mg/L PBTK NA 95% Rat Human -DTXSID4037580 Clint NA 889.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037580 Fup NA 0.8242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037580 Vd NA 0.7269 L/kg 1compartment NA NA Human Human +DTXSID4036489 TK.Half.Life NA 2.506 hours 1compartment NA NA Rat Human +DTXSID4036489 Css NA 0.05526 mg/L 3compartmentss NA 50% Rat Human +DTXSID4036489 Css NA 0.3132 mg/L 3compartmentss NA 95% Rat Human +DTXSID4036489 Css NA 0.03636 mg/L PBTK NA 50% Rat Human +DTXSID4036489 Css NA 0.1964 mg/L PBTK NA 95% Rat Human +DTXSID4037168 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037168 Fup 0.02 NA NA https://doi.org/10.1002/bdd.711 NA Human Human +DTXSID4037168 Vd NA 2.755 L/kg 1compartment NA NA Human Human +DTXSID4037168 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4037168 TK.Half.Life NA 40.18 hours 1compartment NA NA Human Human +DTXSID4037168 Css NA 1.324 mg/L 3compartmentss NA 50% Human Human +DTXSID4037168 Css NA 9.174 mg/L 3compartmentss NA 95% Human Human +DTXSID4037168 Css NA 1.324 mg/L PBTK NA 50% Human Human +DTXSID4037168 Css NA 9.174 mg/L PBTK NA 95% Human Human +DTXSID4037168 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037168 Fup 0.02 NA NA https://doi.org/10.1002/bdd.711 NA Rat Human +DTXSID4037168 Vd NA 2.06 L/kg 1compartment NA NA Rat Human +DTXSID4037168 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4037168 TK.Half.Life NA 8.117 hours 1compartment NA NA Rat Human +DTXSID4037168 Css NA 0.1629 mg/L 3compartmentss NA 50% Rat Human +DTXSID4037168 Css NA 0.9346 mg/L 3compartmentss NA 95% Rat Human +DTXSID4037168 Css NA 0.1687 mg/L PBTK NA 50% Rat Human +DTXSID4037168 Css NA 0.9676 mg/L PBTK NA 95% Rat Human +DTXSID4037580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037580 Fup 0.85 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037580 Vd NA 0.7406 L/kg 1compartment NA NA Human Human DTXSID4037580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4037580 TK.Half.Life NA 0.437 hours 1compartment NA NA Human Human -DTXSID4037580 Css NA 0.0007276 mg/L 3compartmentss NA 50% Human Human -DTXSID4037580 Css NA 0.007955 mg/L 3compartmentss NA 95% Human Human -DTXSID4037580 Css NA 0.0005807 mg/L PBTK NA 50% Human Human -DTXSID4037580 Css NA 0.005454 mg/L PBTK NA 95% Human Human -DTXSID4037580 Clint NA 889.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037580 Fup NA 0.8242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037580 Vd NA 0.7551 L/kg 1compartment NA NA Rat Human +DTXSID4037580 TK.Half.Life NA 5.645 hours 1compartment NA NA Human Human +DTXSID4037580 Css NA 0.9322 mg/L 3compartmentss NA 50% Human Human +DTXSID4037580 Css NA 5.604 mg/L 3compartmentss NA 95% Human Human +DTXSID4037580 Css NA 0.7678 mg/L PBTK NA 50% Human Human +DTXSID4037580 Css NA 3.628 mg/L PBTK NA 95% Human Human +DTXSID4037580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037580 Fup 0.85 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037580 Vd NA 0.7696 L/kg 1compartment NA NA Rat Human DTXSID4037580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4037580 TK.Half.Life NA 0.1956 hours 1compartment NA NA Rat Human -DTXSID4037580 Css NA 0.0003802 mg/L 3compartmentss NA 50% Rat Human -DTXSID4037580 Css NA 0.003734 mg/L 3compartmentss NA 95% Rat Human -DTXSID4037580 Css NA 0.0003004 mg/L PBTK NA 50% Rat Human -DTXSID4037580 Css NA 0.002563 mg/L PBTK NA 95% Rat Human -DTXSID4037582 Clint NA 8.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037582 Fup NA 0.6432 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037582 Vd NA 0.9915 L/kg 1compartment NA NA Human Human +DTXSID4037580 TK.Half.Life NA 1.997 hours 1compartment NA NA Rat Human +DTXSID4037580 Css NA 0.05454 mg/L 3compartmentss NA 50% Rat Human +DTXSID4037580 Css NA 0.3229 mg/L 3compartmentss NA 95% Rat Human +DTXSID4037580 Css NA 0.04534 mg/L PBTK NA 50% Rat Human +DTXSID4037580 Css NA 0.2006 mg/L PBTK NA 95% Rat Human +DTXSID4037582 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037582 Fup 0.631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037582 Vd NA 0.9707 L/kg 1compartment NA NA Human Human DTXSID4037582 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4037582 TK.Half.Life NA 1.235 hours 1compartment NA NA Human Human -DTXSID4037582 Css NA 0.08301 mg/L 3compartmentss NA 50% Human Human -DTXSID4037582 Css NA 0.8318 mg/L 3compartmentss NA 95% Human Human -DTXSID4037582 Css NA 0.07008 mg/L PBTK NA 50% Human Human -DTXSID4037582 Css NA 0.5703 mg/L PBTK NA 95% Human Human -DTXSID4037582 Clint NA 8.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037582 Fup NA 0.6432 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037582 Vd NA 0.938 L/kg 1compartment NA NA Rat Human +DTXSID4037582 TK.Half.Life NA 0.8399 hours 1compartment NA NA Human Human +DTXSID4037582 Css NA 0.03064 mg/L 3compartmentss NA 50% Human Human +DTXSID4037582 Css NA 0.3528 mg/L 3compartmentss NA 95% Human Human +DTXSID4037582 Css NA 0.02561 mg/L PBTK NA 50% Human Human +DTXSID4037582 Css NA 0.2424 mg/L PBTK NA 95% Human Human +DTXSID4037582 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037582 Fup 0.631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037582 Vd NA 0.9201 L/kg 1compartment NA NA Rat Human DTXSID4037582 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4037582 TK.Half.Life NA 0.6145 hours 1compartment NA NA Rat Human -DTXSID4037582 Css NA 0.0409 mg/L 3compartmentss NA 50% Rat Human -DTXSID4037582 Css NA 0.3528 mg/L 3compartmentss NA 95% Rat Human -DTXSID4037582 Css NA 0.03383 mg/L PBTK NA 50% Rat Human -DTXSID4037582 Css NA 0.2147 mg/L PBTK NA 95% Rat Human -DTXSID4037584 Clint NA 6.545 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037584 Fup NA 0.0433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037584 Vd NA 3.05 L/kg 1compartment NA NA Human Human -DTXSID4037584 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID4037584 TK.Half.Life NA 170.5 hours 1compartment NA NA Human Human -DTXSID4037584 Css NA 7.05 mg/L 3compartmentss NA 50% Human Human -DTXSID4037584 Css NA 42.38 mg/L 3compartmentss NA 95% Human Human -DTXSID4037584 Css NA 4.875 mg/L PBTK NA 50% Human Human -DTXSID4037584 Css NA 28.5 mg/L PBTK NA 95% Human Human -DTXSID4037584 Clint NA 6.545 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037584 Fup NA 0.0433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037584 Vd NA 2.286 L/kg 1compartment NA NA Rat Human -DTXSID4037584 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID4037584 TK.Half.Life NA 24.51 hours 1compartment NA NA Rat Human -DTXSID4037584 Css NA 3.906 mg/L 3compartmentss NA 50% Rat Human -DTXSID4037584 Css NA 18.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID4037584 Css NA 2.575 mg/L PBTK NA 50% Rat Human -DTXSID4037584 Css NA 11.65 mg/L PBTK NA 95% Rat Human -DTXSID4037617 Clint NA 98.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037617 Fup NA 0.0956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037617 Vd NA 1.728 L/kg 1compartment NA NA Human Human +DTXSID4037582 TK.Half.Life NA 0.3923 hours 1compartment NA NA Rat Human +DTXSID4037582 Css NA 0.003666 mg/L 3compartmentss NA 50% Rat Human +DTXSID4037582 Css NA 0.03466 mg/L 3compartmentss NA 95% Rat Human +DTXSID4037582 Css NA 0.00311 mg/L PBTK NA 50% Rat Human +DTXSID4037582 Css NA 0.02394 mg/L PBTK NA 95% Rat Human +DTXSID4037584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037584 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037584 Vd NA 2.804 L/kg 1compartment NA NA Human Human +DTXSID4037584 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID4037584 TK.Half.Life NA 55.85 hours 1compartment NA NA Human Human +DTXSID4037584 Css NA 2.638 mg/L 3compartmentss NA 50% Human Human +DTXSID4037584 Css NA 17.96 mg/L 3compartmentss NA 95% Human Human +DTXSID4037584 Css NA 1.773 mg/L PBTK NA 50% Human Human +DTXSID4037584 Css NA 11.69 mg/L PBTK NA 95% Human Human +DTXSID4037584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037584 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037584 Vd NA 2.096 L/kg 1compartment NA NA Rat Human +DTXSID4037584 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID4037584 TK.Half.Life NA 10.83 hours 1compartment NA NA Rat Human +DTXSID4037584 Css NA 0.3423 mg/L 3compartmentss NA 50% Rat Human +DTXSID4037584 Css NA 2.137 mg/L 3compartmentss NA 95% Rat Human +DTXSID4037584 Css NA 0.2266 mg/L PBTK NA 50% Rat Human +DTXSID4037584 Css NA 1.362 mg/L PBTK NA 95% Rat Human +DTXSID4037611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037611 Fup 0.00117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037611 Vd NA 6.391 L/kg 1compartment NA NA Human Human +DTXSID4037611 Days.Css NA 41 Days PBTK NA NA Human Human +DTXSID4037611 TK.Half.Life NA 212 hours 1compartment NA NA Human Human +DTXSID4037611 Css NA 2.923 mg/L 3compartmentss NA 50% Human Human +DTXSID4037611 Css NA 16.84 mg/L 3compartmentss NA 95% Human Human +DTXSID4037611 Css NA 2.644 mg/L PBTK NA 50% Human Human +DTXSID4037611 Css NA 15.09 mg/L PBTK NA 95% Human Human +DTXSID4037611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037611 Fup 0.00117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037611 Vd NA 4.932 L/kg 1compartment NA NA Rat Human +DTXSID4037611 Days.Css NA 24 Days PBTK NA NA Rat Human +DTXSID4037611 TK.Half.Life NA 37.19 hours 1compartment NA NA Rat Human +DTXSID4037611 Css NA 0.3769 mg/L 3compartmentss NA 50% Rat Human +DTXSID4037611 Css NA 1.767 mg/L 3compartmentss NA 95% Rat Human +DTXSID4037611 Css NA 0.3426 mg/L PBTK NA 50% Rat Human +DTXSID4037611 Css NA 1.63 mg/L PBTK NA 95% Rat Human +DTXSID4037617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037617 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4037617 Vd NA 2.1 L/kg 1compartment NA NA Human Human DTXSID4037617 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4037617 TK.Half.Life NA 2.335 hours 1compartment NA NA Human Human -DTXSID4037617 Css NA 0.08074 mg/L 3compartmentss NA 50% Human Human -DTXSID4037617 Css NA 0.6223 mg/L 3compartmentss NA 95% Human Human -DTXSID4037617 Css NA 0.0537 mg/L PBTK NA 50% Human Human -DTXSID4037617 Css NA 0.3969 mg/L PBTK NA 95% Human Human -DTXSID4037617 Clint NA 98.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037617 Fup NA 0.0956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037617 Vd NA 1.309 L/kg 1compartment NA NA Rat Human +DTXSID4037617 TK.Half.Life NA 5.196 hours 1compartment NA NA Human Human +DTXSID4037617 Css NA 0.2165 mg/L 3compartmentss NA 50% Human Human +DTXSID4037617 Css NA 1.435 mg/L 3compartmentss NA 95% Human Human +DTXSID4037617 Css NA 0.152 mg/L PBTK NA 50% Human Human +DTXSID4037617 Css NA 0.9552 mg/L PBTK NA 95% Human Human +DTXSID4037617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037617 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4037617 Vd NA 1.6 L/kg 1compartment NA NA Rat Human DTXSID4037617 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4037617 TK.Half.Life NA 0.8145 hours 1compartment NA NA Rat Human -DTXSID4037617 Css NA 0.04649 mg/L 3compartmentss NA 50% Rat Human -DTXSID4037617 Css NA 0.2815 mg/L 3compartmentss NA 95% Rat Human -DTXSID4037617 Css NA 0.02916 mg/L PBTK NA 50% Rat Human -DTXSID4037617 Css NA 0.1694 mg/L PBTK NA 95% Rat Human -DTXSID4037748 Clint NA 1.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037748 Fup NA 0.4292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4037748 Vd NA 3.127 L/kg 1compartment NA NA Human Human -DTXSID4037748 Days.Css NA 133 Days PBTK NA NA Human Human -DTXSID4037748 TK.Half.Life NA 561.3 hours 1compartment NA NA Human Human -DTXSID4037748 Css NA 21.43 mg/L 3compartmentss NA 50% Human Human -DTXSID4037748 Css NA 86.28 mg/L 3compartmentss NA 95% Human Human -DTXSID4037748 Css NA 15.05 mg/L PBTK NA 50% Human Human -DTXSID4037748 Css NA 58.45 mg/L PBTK NA 95% Human Human -DTXSID4037748 Clint NA 1.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037748 Fup NA 0.4292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4037748 Vd NA 2.349 L/kg 1compartment NA NA Rat Human -DTXSID4037748 Days.Css NA 61 Days PBTK NA NA Rat Human -DTXSID4037748 TK.Half.Life NA 63.3 hours 1compartment NA NA Rat Human -DTXSID4037748 Css NA 10.26 mg/L 3compartmentss NA 50% Rat Human -DTXSID4037748 Css NA 28.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID4037748 Css NA 6.942 mg/L PBTK NA 50% Rat Human -DTXSID4037748 Css NA 18.3 mg/L PBTK NA 95% Rat Human -DTXSID4038762 Clint NA 2.993 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4038762 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4038762 Vd NA 1.779 L/kg 1compartment NA NA Human Human +DTXSID4037617 TK.Half.Life NA 1.679 hours 1compartment NA NA Rat Human +DTXSID4037617 Css NA 0.02786 mg/L 3compartmentss NA 50% Rat Human +DTXSID4037617 Css NA 0.144 mg/L 3compartmentss NA 95% Rat Human +DTXSID4037617 Css NA 0.0194 mg/L PBTK NA 50% Rat Human +DTXSID4037617 Css NA 0.09715 mg/L PBTK NA 95% Rat Human +DTXSID4038762 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038762 Fup 0.562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038762 Vd NA 0.5537 L/kg 1compartment NA NA Human Human DTXSID4038762 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4038762 TK.Half.Life NA 2.907 hours 1compartment NA NA Human Human -DTXSID4038762 Css NA 0.1276 mg/L 3compartmentss NA 50% Human Human -DTXSID4038762 Css NA 1.112 mg/L 3compartmentss NA 95% Human Human -DTXSID4038762 Css NA 0.1254 mg/L PBTK NA 50% Human Human -DTXSID4038762 Css NA 0.8576 mg/L PBTK NA 95% Human Human -DTXSID4038762 Clint NA 2.993 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4038762 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4038762 Vd NA 1.576 L/kg 1compartment NA NA Rat Human +DTXSID4038762 TK.Half.Life NA 6.377 hours 1compartment NA NA Human Human +DTXSID4038762 Css NA 1.301 mg/L 3compartmentss NA 50% Human Human +DTXSID4038762 Css NA 8.62 mg/L 3compartmentss NA 95% Human Human +DTXSID4038762 Css NA 0.997 mg/L PBTK NA 50% Human Human +DTXSID4038762 Css NA 5.385 mg/L PBTK NA 95% Human Human +DTXSID4038762 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038762 Fup 0.562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038762 Vd NA 0.5794 L/kg 1compartment NA NA Rat Human DTXSID4038762 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4038762 TK.Half.Life NA 1.221 hours 1compartment NA NA Rat Human -DTXSID4038762 Css NA 0.05569 mg/L 3compartmentss NA 50% Rat Human -DTXSID4038762 Css NA 0.4289 mg/L 3compartmentss NA 95% Rat Human -DTXSID4038762 Css NA 0.05473 mg/L PBTK NA 50% Rat Human -DTXSID4038762 Css NA 0.2807 mg/L PBTK NA 95% Rat Human -DTXSID4038847 Clint NA 30.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4038847 Fup NA 0.143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4038847 Vd NA 1.299 L/kg 1compartment NA NA Human Human -DTXSID4038847 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4038847 TK.Half.Life NA 2.055 hours 1compartment NA NA Human Human -DTXSID4038847 Css NA 0.1197 mg/L 3compartmentss NA 50% Human Human -DTXSID4038847 Css NA 1.008 mg/L 3compartmentss NA 95% Human Human -DTXSID4038847 Css NA 0.08722 mg/L PBTK NA 50% Human Human -DTXSID4038847 Css NA 0.6604 mg/L PBTK NA 95% Human Human -DTXSID4038847 Clint NA 30.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4038847 Fup NA 0.143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4038847 Vd NA 1.271 L/kg 1compartment NA NA Rat Human -DTXSID4038847 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4038847 TK.Half.Life NA 1.127 hours 1compartment NA NA Rat Human -DTXSID4038847 Css NA 0.06584 mg/L 3compartmentss NA 50% Rat Human -DTXSID4038847 Css NA 0.4624 mg/L 3compartmentss NA 95% Rat Human -DTXSID4038847 Css NA 0.04562 mg/L PBTK NA 50% Rat Human -DTXSID4038847 Css NA 0.2865 mg/L PBTK NA 95% Rat Human +DTXSID4038762 TK.Half.Life NA 2.274 hours 1compartment NA NA Rat Human +DTXSID4038762 Css NA 0.08138 mg/L 3compartmentss NA 50% Rat Human +DTXSID4038762 Css NA 0.5101 mg/L 3compartmentss NA 95% Rat Human +DTXSID4038762 Css NA 0.06136 mg/L PBTK NA 50% Rat Human +DTXSID4038762 Css NA 0.3051 mg/L PBTK NA 95% Rat Human +DTXSID4038845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038845 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038845 Vd NA 1.285 L/kg 1compartment NA NA Human Human +DTXSID4038845 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4038845 TK.Half.Life NA 1.352 hours 1compartment NA NA Human Human +DTXSID4038845 Css NA 0.0448 mg/L 3compartmentss NA 50% Human Human +DTXSID4038845 Css NA 0.3489 mg/L 3compartmentss NA 95% Human Human +DTXSID4038845 Css NA 0.03633 mg/L PBTK NA 50% Human Human +DTXSID4038845 Css NA 0.2471 mg/L PBTK NA 95% Human Human +DTXSID4038845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038845 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038845 Vd NA 1.103 L/kg 1compartment NA NA Rat Human +DTXSID4038845 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4038845 TK.Half.Life NA 0.5733 hours 1compartment NA NA Rat Human +DTXSID4038845 Css NA 0.005353 mg/L 3compartmentss NA 50% Rat Human +DTXSID4038845 Css NA 0.03691 mg/L 3compartmentss NA 95% Rat Human +DTXSID4038845 Css NA 0.004377 mg/L PBTK NA 50% Rat Human +DTXSID4038845 Css NA 0.02583 mg/L PBTK NA 95% Rat Human +DTXSID4038847 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038847 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038847 Vd NA 1.88 L/kg 1compartment NA NA Human Human +DTXSID4038847 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4038847 TK.Half.Life NA 36.27 hours 1compartment NA NA Human Human +DTXSID4038847 Css NA 1.704 mg/L 3compartmentss NA 50% Human Human +DTXSID4038847 Css NA 7.827 mg/L 3compartmentss NA 95% Human Human +DTXSID4038847 Css NA 1.54 mg/L PBTK NA 50% Human Human +DTXSID4038847 Css NA 5.595 mg/L PBTK NA 95% Human Human +DTXSID4038847 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038847 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038847 Vd NA 1.88 L/kg 1compartment NA NA Rat Human +DTXSID4038847 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4038847 TK.Half.Life NA 12.2 hours 1compartment NA NA Rat Human +DTXSID4038847 Css NA 0.1078 mg/L 3compartmentss NA 50% Rat Human +DTXSID4038847 Css NA 0.4116 mg/L 3compartmentss NA 95% Rat Human +DTXSID4038847 Css NA 0.09786 mg/L PBTK NA 50% Rat Human +DTXSID4038847 Css NA 0.2806 mg/L PBTK NA 95% Rat Human DTXSID4038899 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4038899 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4038899 Vd NA 384.1 L/kg 1compartment NA NA Human Human -DTXSID4038899 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4038899 TK.Half.Life NA 18730000 hours 1compartment NA NA Human Human -DTXSID4038899 Css NA 1.105 mg/L 3compartmentss NA 50% Human Human -DTXSID4038899 Css NA 7.793 mg/L 3compartmentss NA 95% Human Human -DTXSID4038899 Css NA 61.22 mg/L PBTK NA 50% Human Human -DTXSID4038899 Css NA 387.6 mg/L PBTK NA 95% Human Human +DTXSID4038899 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038899 Vd NA 13.54 L/kg 1compartment NA NA Human Human +DTXSID4038899 Days.Css NA 8526 Days PBTK NA NA Human Human +DTXSID4038899 TK.Half.Life NA 644200 hours 1compartment NA NA Human Human +DTXSID4038899 Css NA 39.62 mg/L 3compartmentss NA 50% Human Human +DTXSID4038899 Css NA 275.7 mg/L 3compartmentss NA 95% Human Human +DTXSID4038899 Css NA 60.59 mg/L PBTK NA 50% Human Human +DTXSID4038899 Css NA 386.2 mg/L PBTK NA 95% Human Human DTXSID4038899 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4038899 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4038899 Vd NA 344.9 L/kg 1compartment NA NA Rat Human -DTXSID4038899 Days.Css NA 13780 Days PBTK NA NA Rat Human -DTXSID4038899 TK.Half.Life NA 1459000 hours 1compartment NA NA Rat Human -DTXSID4038899 Css NA 0.549 mg/L 3compartmentss NA 50% Rat Human -DTXSID4038899 Css NA 2.523 mg/L 3compartmentss NA 95% Rat Human -DTXSID4038899 Css NA 34.17 mg/L PBTK NA 50% Rat Human -DTXSID4038899 Css NA 136.6 mg/L PBTK NA 95% Rat Human -DTXSID4038922 Clint NA 7.919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4038922 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4038922 Vd NA 3.075 L/kg 1compartment NA NA Human Human -DTXSID4038922 Days.Css NA 48 Days PBTK NA NA Human Human -DTXSID4038922 TK.Half.Life NA 234.5 hours 1compartment NA NA Human Human -DTXSID4038922 Css NA 9.708 mg/L 3compartmentss NA 50% Human Human -DTXSID4038922 Css NA 57.99 mg/L 3compartmentss NA 95% Human Human -DTXSID4038922 Css NA 6.718 mg/L PBTK NA 50% Human Human -DTXSID4038922 Css NA 38.72 mg/L PBTK NA 95% Human Human -DTXSID4038922 Clint NA 7.919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4038922 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4038922 Vd NA 2.303 L/kg 1compartment NA NA Rat Human -DTXSID4038922 Days.Css NA 27 Days PBTK NA NA Rat Human -DTXSID4038922 TK.Half.Life NA 32.62 hours 1compartment NA NA Rat Human -DTXSID4038922 Css NA 5.406 mg/L 3compartmentss NA 50% Rat Human -DTXSID4038922 Css NA 25.94 mg/L 3compartmentss NA 95% Rat Human -DTXSID4038922 Css NA 3.57 mg/L PBTK NA 50% Rat Human -DTXSID4038922 Css NA 16.67 mg/L PBTK NA 95% Rat Human +DTXSID4038899 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038899 Vd NA 10.81 L/kg 1compartment NA NA Rat Human +DTXSID4038899 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID4038899 TK.Half.Life NA 43430 hours 1compartment NA NA Rat Human +DTXSID4038899 Css NA 4.781 mg/L 3compartmentss NA 50% Rat Human +DTXSID4038899 Css NA 22.3 mg/L 3compartmentss NA 95% Rat Human +DTXSID4038899 Css NA 7.777 mg/L PBTK NA 50% Rat Human +DTXSID4038899 Css NA 33.32 mg/L PBTK NA 95% Rat Human +DTXSID4038922 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038922 Fup 0.00665 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038922 Vd NA 2.753 L/kg 1compartment NA NA Human Human +DTXSID4038922 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID4038922 TK.Half.Life NA 63.19 hours 1compartment NA NA Human Human +DTXSID4038922 Css NA 2.73 mg/L 3compartmentss NA 50% Human Human +DTXSID4038922 Css NA 20.16 mg/L 3compartmentss NA 95% Human Human +DTXSID4038922 Css NA 1.82 mg/L PBTK NA 50% Human Human +DTXSID4038922 Css NA 12.98 mg/L PBTK NA 95% Human Human +DTXSID4038922 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038922 Fup 0.00665 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038922 Vd NA 2.055 L/kg 1compartment NA NA Rat Human +DTXSID4038922 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4038922 TK.Half.Life NA 12.72 hours 1compartment NA NA Rat Human +DTXSID4038922 Css NA 0.1023 mg/L 3compartmentss NA 50% Rat Human +DTXSID4038922 Css NA 0.8261 mg/L 3compartmentss NA 95% Rat Human +DTXSID4038922 Css NA 0.06621 mg/L PBTK NA 50% Rat Human +DTXSID4038922 Css NA 0.5115 mg/L PBTK NA 95% Rat Human DTXSID4038924 Clint 191.4 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID4038924 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID4038924 Clint 191.4 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID4038924 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID4038926 Clint NA 43.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4038926 Fup NA 0.0366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4038926 Vd NA 0.6265 L/kg 1compartment NA NA Human Human +DTXSID4038926 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038926 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4038926 Vd NA 1.248 L/kg 1compartment NA NA Human Human DTXSID4038926 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4038926 TK.Half.Life NA 1.999 hours 1compartment NA NA Human Human -DTXSID4038926 Css NA 0.4422 mg/L 3compartmentss NA 50% Human Human -DTXSID4038926 Css NA 3.841 mg/L 3compartmentss NA 95% Human Human -DTXSID4038926 Css NA 0.2694 mg/L PBTK NA 50% Human Human -DTXSID4038926 Css NA 2.292 mg/L PBTK NA 95% Human Human -DTXSID4038926 Clint NA 43.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4038926 Fup NA 0.0366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4038926 Vd NA 0.4906 L/kg 1compartment NA NA Rat Human +DTXSID4038926 TK.Half.Life NA 5.154 hours 1compartment NA NA Human Human +DTXSID4038926 Css NA 0.5416 mg/L 3compartmentss NA 50% Human Human +DTXSID4038926 Css NA 4.202 mg/L 3compartmentss NA 95% Human Human +DTXSID4038926 Css NA 0.3434 mg/L PBTK NA 50% Human Human +DTXSID4038926 Css NA 2.55 mg/L PBTK NA 95% Human Human +DTXSID4038926 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038926 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4038926 Vd NA 0.9461 L/kg 1compartment NA NA Rat Human DTXSID4038926 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4038926 TK.Half.Life NA 0.9332 hours 1compartment NA NA Rat Human -DTXSID4038926 Css NA 0.2492 mg/L 3compartmentss NA 50% Rat Human -DTXSID4038926 Css NA 1.739 mg/L 3compartmentss NA 95% Rat Human -DTXSID4038926 Css NA 0.1414 mg/L PBTK NA 50% Rat Human -DTXSID4038926 Css NA 0.9698 mg/L PBTK NA 95% Rat Human -DTXSID4039235 Clint NA 2.188 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4039235 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4039235 Vd NA 1.975 L/kg 1compartment NA NA Human Human -DTXSID4039235 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID4039235 TK.Half.Life NA 108.8 hours 1compartment NA NA Human Human -DTXSID4039235 Css NA 8.767 mg/L 3compartmentss NA 50% Human Human -DTXSID4039235 Css NA 47.08 mg/L 3compartmentss NA 95% Human Human -DTXSID4039235 Css NA 5.701 mg/L PBTK NA 50% Human Human -DTXSID4039235 Css NA 28.77 mg/L PBTK NA 95% Human Human -DTXSID4039235 Clint NA 2.188 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4039235 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4039235 Vd NA 1.474 L/kg 1compartment NA NA Rat Human -DTXSID4039235 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID4039235 TK.Half.Life NA 31.45 hours 1compartment NA NA Rat Human -DTXSID4039235 Css NA 4.328 mg/L 3compartmentss NA 50% Rat Human -DTXSID4039235 Css NA 17.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID4039235 Css NA 2.641 mg/L PBTK NA 50% Rat Human -DTXSID4039235 Css NA 9.739 mg/L PBTK NA 95% Rat Human -DTXSID4039657 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4038926 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human +DTXSID4038926 Css NA 0.07043 mg/L 3compartmentss NA 50% Rat Human +DTXSID4038926 Css NA 0.4263 mg/L 3compartmentss NA 95% Rat Human +DTXSID4038926 Css NA 0.04348 mg/L PBTK NA 50% Rat Human +DTXSID4038926 Css NA 0.2528 mg/L PBTK NA 95% Rat Human +DTXSID4039235 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4039235 Fup 0.0562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4039235 Vd NA 1.392 L/kg 1compartment NA NA Human Human +DTXSID4039235 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4039235 TK.Half.Life NA 5.869 hours 1compartment NA NA Human Human +DTXSID4039235 Css NA 0.5464 mg/L 3compartmentss NA 50% Human Human +DTXSID4039235 Css NA 4.053 mg/L 3compartmentss NA 95% Human Human +DTXSID4039235 Css NA 0.3495 mg/L PBTK NA 50% Human Human +DTXSID4039235 Css NA 2.533 mg/L PBTK NA 95% Human Human +DTXSID4039235 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4039235 Fup 0.0562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4039235 Vd NA 1.052 L/kg 1compartment NA NA Rat Human +DTXSID4039235 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4039235 TK.Half.Life NA 2.335 hours 1compartment NA NA Rat Human +DTXSID4039235 Css NA 0.07066 mg/L 3compartmentss NA 50% Rat Human +DTXSID4039235 Css NA 0.4377 mg/L 3compartmentss NA 95% Rat Human +DTXSID4039235 Css NA 0.04414 mg/L PBTK NA 50% Rat Human +DTXSID4039235 Css NA 0.2606 mg/L PBTK NA 95% Rat Human +DTXSID4039657 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4039657 Fup 0.76 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4039657 Vd NA 0.6873 L/kg 1compartment NA NA Human Human DTXSID4039657 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4039657 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID4039657 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human -DTXSID4039657 Css NA 6.266 mg/L 3compartmentss NA 95% Human Human -DTXSID4039657 Css NA 0.8422 mg/L PBTK NA 50% Human Human -DTXSID4039657 Css NA 3.992 mg/L PBTK NA 95% Human Human -DTXSID4039657 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4039657 Css NA 0.5649 mg/L 3compartmentss NA 50% Human Human +DTXSID4039657 Css NA 3.583 mg/L 3compartmentss NA 95% Human Human +DTXSID4039657 Css NA 0.4596 mg/L PBTK NA 50% Human Human +DTXSID4039657 Css NA 2.291 mg/L PBTK NA 95% Human Human +DTXSID4039657 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4039657 Fup 0.76 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4039657 Vd NA 0.7146 L/kg 1compartment NA NA Rat Human DTXSID4039657 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4039657 TK.Half.Life NA 2.073 hours 1compartment NA NA Rat Human -DTXSID4039657 Css NA 0.2679 mg/L 3compartmentss NA 50% Rat Human -DTXSID4039657 Css NA 1.685 mg/L 3compartmentss NA 95% Rat Human -DTXSID4039657 Css NA 0.2097 mg/L PBTK NA 50% Rat Human -DTXSID4039657 Css NA 0.9959 mg/L PBTK NA 95% Rat Human +DTXSID4039657 Css NA 0.002914 mg/L 3compartmentss NA 50% Rat Human +DTXSID4039657 Css NA 0.02014 mg/L 3compartmentss NA 95% Rat Human +DTXSID4039657 Css NA 0.002294 mg/L PBTK NA 50% Rat Human +DTXSID4039657 Css NA 0.01233 mg/L PBTK NA 95% Rat Human DTXSID4040002 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID4040002 Fup 0.2077 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID4040002 Vd NA 0.4368 L/kg 1compartment NA NA Human Human -DTXSID4040002 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4040002 TK.Half.Life NA 13.69 hours 1compartment NA NA Human Human -DTXSID4040002 Css NA 3.743 mg/L 3compartmentss NA 50% Human Human -DTXSID4040002 Css NA 13.83 mg/L 3compartmentss NA 95% Human Human -DTXSID4040002 Css NA 2.544 mg/L PBTK NA 50% Human Human -DTXSID4040002 Css NA 8.617 mg/L PBTK NA 95% Human Human +DTXSID4040002 Vd NA 0.5528 L/kg 1compartment NA NA Human Human +DTXSID4040002 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4040002 TK.Half.Life NA 17.51 hours 1compartment NA NA Human Human +DTXSID4040002 Css NA 3.524 mg/L 3compartmentss NA 50% Human Human +DTXSID4040002 Css NA 13.31 mg/L 3compartmentss NA 95% Human Human +DTXSID4040002 Css NA 2.48 mg/L PBTK NA 50% Human Human +DTXSID4040002 Css NA 8.381 mg/L PBTK NA 95% Human Human DTXSID4040002 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID4040002 Fup 0.2077 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID4040002 Vd NA 0.4175 L/kg 1compartment NA NA Rat Human +DTXSID4040002 Vd NA 0.5084 L/kg 1compartment NA NA Rat Human DTXSID4040002 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040002 TK.Half.Life NA 4.438 hours 1compartment NA NA Rat Human -DTXSID4040002 Css NA 1.045 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040002 Css NA 3.149 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040002 Css NA 0.6721 mg/L PBTK NA 50% Rat Human -DTXSID4040002 Css NA 1.82 mg/L PBTK NA 95% Rat Human +DTXSID4040002 TK.Half.Life NA 5.419 hours 1compartment NA NA Rat Human +DTXSID4040002 Css NA 0.2218 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040002 Css NA 0.6871 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040002 Css NA 0.1533 mg/L PBTK NA 50% Rat Human +DTXSID4040002 Css NA 0.4181 mg/L PBTK NA 95% Rat Human +DTXSID4040137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040137 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040137 Vd NA 4.144 L/kg 1compartment NA NA Human Human +DTXSID4040137 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4040137 TK.Half.Life NA 2.792 hours 1compartment NA NA Human Human +DTXSID4040137 Css NA 0.02092 mg/L 3compartmentss NA 50% Human Human +DTXSID4040137 Css NA 0.2764 mg/L 3compartmentss NA 95% Human Human +DTXSID4040137 Css NA 0.0272 mg/L PBTK NA 50% Human Human +DTXSID4040137 Css NA 0.25 mg/L PBTK NA 95% Human Human +DTXSID4040137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040137 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040137 Vd NA 4.172 L/kg 1compartment NA NA Rat Human +DTXSID4040137 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4040137 TK.Half.Life NA 1.438 hours 1compartment NA NA Rat Human +DTXSID4040137 Css NA 0.002482 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040137 Css NA 0.02731 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040137 Css NA 0.003394 mg/L PBTK NA 50% Rat Human +DTXSID4040137 Css NA 0.02382 mg/L PBTK NA 95% Rat Human DTXSID4040187 Clint 15.49 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4040187 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4040187 Vd NA 1.431 L/kg 1compartment NA NA Human Human DTXSID4040187 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4040187 TK.Half.Life NA 7.187 hours 1compartment NA NA Human Human -DTXSID4040187 Css NA 0.693 mg/L 3compartmentss NA 50% Human Human -DTXSID4040187 Css NA 5.085 mg/L 3compartmentss NA 95% Human Human -DTXSID4040187 Css NA 0.4613 mg/L PBTK NA 50% Human Human -DTXSID4040187 Css NA 3.178 mg/L PBTK NA 95% Human Human +DTXSID4040187 Css NA 0.6498 mg/L 3compartmentss NA 50% Human Human +DTXSID4040187 Css NA 4.585 mg/L 3compartmentss NA 95% Human Human +DTXSID4040187 Css NA 0.448 mg/L PBTK NA 50% Human Human +DTXSID4040187 Css NA 3.163 mg/L PBTK NA 95% Human Human DTXSID4040187 Clint 15.49 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4040187 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4040187 Vd NA 1.146 L/kg 1compartment NA NA Rat Human DTXSID4040187 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4040187 TK.Half.Life NA 3.156 hours 1compartment NA NA Rat Human -DTXSID4040187 Css NA 0.3811 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040187 Css NA 2.256 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040187 Css NA 0.2386 mg/L PBTK NA 50% Rat Human -DTXSID4040187 Css NA 1.325 mg/L PBTK NA 95% Rat Human +DTXSID4040187 Css NA 0.07772 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040187 Css NA 0.4411 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040187 Css NA 0.05551 mg/L PBTK NA 50% Rat Human +DTXSID4040187 Css NA 0.3153 mg/L PBTK NA 95% Rat Human DTXSID4040264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4040264 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040264 Vd NA 2.055 L/kg 1compartment NA NA Human Human -DTXSID4040264 Days.Css NA 1762 Days PBTK NA NA Human Human -DTXSID4040264 TK.Half.Life NA 6454 hours 1compartment NA NA Human Human -DTXSID4040264 Css NA 463.6 mg/L 3compartmentss NA 50% Human Human -DTXSID4040264 Css NA 1933 mg/L 3compartmentss NA 95% Human Human -DTXSID4040264 Css NA 294.9 mg/L PBTK NA 50% Human Human -DTXSID4040264 Css NA 1140 mg/L PBTK NA 95% Human Human +DTXSID4040264 Vd NA 1.775 L/kg 1compartment NA NA Human Human +DTXSID4040264 Days.Css NA 1236 Days PBTK NA NA Human Human +DTXSID4040264 TK.Half.Life NA 4545 hours 1compartment NA NA Human Human +DTXSID4040264 Css NA 383.6 mg/L 3compartmentss NA 50% Human Human +DTXSID4040264 Css NA 1729 mg/L 3compartmentss NA 95% Human Human +DTXSID4040264 Css NA 240.1 mg/L PBTK NA 50% Human Human +DTXSID4040264 Css NA 1020 mg/L PBTK NA 95% Human Human DTXSID4040264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4040264 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040264 Vd NA 1.521 L/kg 1compartment NA NA Rat Human -DTXSID4040264 Days.Css NA 440 Days PBTK NA NA Rat Human -DTXSID4040264 TK.Half.Life NA 981.7 hours 1compartment NA NA Rat Human -DTXSID4040264 Css NA 128.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040264 Css NA 454.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040264 Css NA 77.24 mg/L PBTK NA 50% Rat Human -DTXSID4040264 Css NA 253.5 mg/L PBTK NA 95% Rat Human -DTXSID4040266 Clint NA 3.224 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040266 Fup NA 0.1177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040266 Vd NA 2.137 L/kg 1compartment NA NA Human Human -DTXSID4040266 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4040266 TK.Half.Life NA 31.61 hours 1compartment NA NA Human Human -DTXSID4040266 Css NA 2 mg/L 3compartmentss NA 50% Human Human -DTXSID4040266 Css NA 10.53 mg/L 3compartmentss NA 95% Human Human -DTXSID4040266 Css NA 1.378 mg/L PBTK NA 50% Human Human -DTXSID4040266 Css NA 6.736 mg/L PBTK NA 95% Human Human -DTXSID4040266 Clint NA 3.224 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040266 Fup NA 0.1177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040266 Vd NA 1.621 L/kg 1compartment NA NA Rat Human -DTXSID4040266 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4040266 TK.Half.Life NA 9.01 hours 1compartment NA NA Rat Human -DTXSID4040266 Css NA 0.9962 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040266 Css NA 3.787 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040266 Css NA 0.6523 mg/L PBTK NA 50% Rat Human -DTXSID4040266 Css NA 2.274 mg/L PBTK NA 95% Rat Human -DTXSID4040268 Clint NA 164.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040268 Fup NA 0.0654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040268 Vd NA 1.907 L/kg 1compartment NA NA Human Human +DTXSID4040264 Vd NA 1.307 L/kg 1compartment NA NA Rat Human +DTXSID4040264 Days.Css NA 305 Days PBTK NA NA Rat Human +DTXSID4040264 TK.Half.Life NA 782.3 hours 1compartment NA NA Rat Human +DTXSID4040264 Css NA 24.54 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040264 Css NA 94.26 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040264 Css NA 14.93 mg/L PBTK NA 50% Rat Human +DTXSID4040264 Css NA 54.01 mg/L PBTK NA 95% Rat Human +DTXSID4040266 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040266 Fup 0.0549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040266 Vd NA 2.393 L/kg 1compartment NA NA Human Human +DTXSID4040266 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4040266 TK.Half.Life NA 14.82 hours 1compartment NA NA Human Human +DTXSID4040266 Css NA 0.7756 mg/L 3compartmentss NA 50% Human Human +DTXSID4040266 Css NA 5.083 mg/L 3compartmentss NA 95% Human Human +DTXSID4040266 Css NA 0.519 mg/L PBTK NA 50% Human Human +DTXSID4040266 Css NA 3.249 mg/L PBTK NA 95% Human Human +DTXSID4040266 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040266 Fup 0.0549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040266 Vd NA 1.793 L/kg 1compartment NA NA Rat Human +DTXSID4040266 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4040266 TK.Half.Life NA 4.021 hours 1compartment NA NA Rat Human +DTXSID4040266 Css NA 0.1003 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040266 Css NA 0.5597 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040266 Css NA 0.06615 mg/L PBTK NA 50% Rat Human +DTXSID4040266 Css NA 0.3504 mg/L PBTK NA 95% Rat Human +DTXSID4040268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040268 Fup 0.048 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040268 Vd NA 1.359 L/kg 1compartment NA NA Human Human DTXSID4040268 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4040268 TK.Half.Life NA 2.504 hours 1compartment NA NA Human Human -DTXSID4040268 Css NA 0.07098 mg/L 3compartmentss NA 50% Human Human -DTXSID4040268 Css NA 0.5209 mg/L 3compartmentss NA 95% Human Human -DTXSID4040268 Css NA 0.04727 mg/L PBTK NA 50% Human Human -DTXSID4040268 Css NA 0.3307 mg/L PBTK NA 95% Human Human -DTXSID4040268 Clint NA 164.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040268 Fup NA 0.0654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040268 Vd NA 1.435 L/kg 1compartment NA NA Rat Human +DTXSID4040268 TK.Half.Life NA 6.394 hours 1compartment NA NA Human Human +DTXSID4040268 Css NA 0.6452 mg/L 3compartmentss NA 50% Human Human +DTXSID4040268 Css NA 5.087 mg/L 3compartmentss NA 95% Human Human +DTXSID4040268 Css NA 0.4095 mg/L PBTK NA 50% Human Human +DTXSID4040268 Css NA 3.089 mg/L PBTK NA 95% Human Human +DTXSID4040268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040268 Fup 0.048 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040268 Vd NA 1.024 L/kg 1compartment NA NA Rat Human DTXSID4040268 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040268 TK.Half.Life NA 0.8415 hours 1compartment NA NA Rat Human -DTXSID4040268 Css NA 0.04064 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040268 Css NA 0.2447 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040268 Css NA 0.02542 mg/L PBTK NA 50% Rat Human -DTXSID4040268 Css NA 0.1477 mg/L PBTK NA 95% Rat Human -DTXSID4040343 Clint NA 0.8223 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040343 Fup NA 0.1594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040343 Vd NA 1.517 L/kg 1compartment NA NA Human Human -DTXSID4040343 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4040343 TK.Half.Life NA 33.26 hours 1compartment NA NA Human Human -DTXSID4040343 Css NA 2.764 mg/L 3compartmentss NA 50% Human Human -DTXSID4040343 Css NA 11.48 mg/L 3compartmentss NA 95% Human Human -DTXSID4040343 Css NA 1.932 mg/L PBTK NA 50% Human Human -DTXSID4040343 Css NA 7.233 mg/L PBTK NA 95% Human Human -DTXSID4040343 Clint NA 0.8223 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040343 Fup NA 0.1594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040343 Vd NA 1.182 L/kg 1compartment NA NA Rat Human -DTXSID4040343 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4040343 TK.Half.Life NA 10.2 hours 1compartment NA NA Rat Human -DTXSID4040343 Css NA 1.115 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040343 Css NA 3.814 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040343 Css NA 0.7385 mg/L PBTK NA 50% Rat Human -DTXSID4040343 Css NA 2.219 mg/L PBTK NA 95% Rat Human -DTXSID4040395 Clint NA 37.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040395 Fup NA 0.5486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040395 Vd NA 1.941 L/kg 1compartment NA NA Human Human +DTXSID4040268 TK.Half.Life NA 2.568 hours 1compartment NA NA Rat Human +DTXSID4040268 Css NA 0.08228 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040268 Css NA 0.5177 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040268 Css NA 0.05101 mg/L PBTK NA 50% Rat Human +DTXSID4040268 Css NA 0.3077 mg/L PBTK NA 95% Rat Human +DTXSID4040343 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040343 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040343 Vd NA 1.357 L/kg 1compartment NA NA Human Human +DTXSID4040343 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4040343 TK.Half.Life NA 2.86 hours 1compartment NA NA Human Human +DTXSID4040343 Css NA 0.1864 mg/L 3compartmentss NA 50% Human Human +DTXSID4040343 Css NA 1.373 mg/L 3compartmentss NA 95% Human Human +DTXSID4040343 Css NA 0.127 mg/L PBTK NA 50% Human Human +DTXSID4040343 Css NA 0.8699 mg/L PBTK NA 95% Human Human +DTXSID4040343 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040343 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040343 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID4040343 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4040343 TK.Half.Life NA 1.152 hours 1compartment NA NA Rat Human +DTXSID4040343 Css NA 0.02387 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040343 Css NA 0.145 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040343 Css NA 0.01604 mg/L PBTK NA 50% Rat Human +DTXSID4040343 Css NA 0.09117 mg/L PBTK NA 95% Rat Human +DTXSID4040395 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040395 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040395 Vd NA 1.491 L/kg 1compartment NA NA Human Human DTXSID4040395 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4040395 TK.Half.Life NA 1.682 hours 1compartment NA NA Human Human -DTXSID4040395 Css NA 0.02849 mg/L 3compartmentss NA 50% Human Human -DTXSID4040395 Css NA 0.2507 mg/L 3compartmentss NA 95% Human Human -DTXSID4040395 Css NA 0.02427 mg/L PBTK NA 50% Human Human -DTXSID4040395 Css NA 0.1865 mg/L PBTK NA 95% Human Human -DTXSID4040395 Clint NA 37.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040395 Fup NA 0.5486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040395 Vd NA 1.586 L/kg 1compartment NA NA Rat Human +DTXSID4040395 TK.Half.Life NA 1.566 hours 1compartment NA NA Human Human +DTXSID4040395 Css NA 0.04479 mg/L 3compartmentss NA 50% Human Human +DTXSID4040395 Css NA 0.3683 mg/L 3compartmentss NA 95% Human Human +DTXSID4040395 Css NA 0.03632 mg/L PBTK NA 50% Human Human +DTXSID4040395 Css NA 0.2675 mg/L PBTK NA 95% Human Human +DTXSID4040395 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040395 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040395 Vd NA 1.253 L/kg 1compartment NA NA Rat Human DTXSID4040395 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040395 TK.Half.Life NA 0.6129 hours 1compartment NA NA Rat Human -DTXSID4040395 Css NA 0.01513 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040395 Css NA 0.119 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040395 Css NA 0.0125 mg/L PBTK NA 50% Rat Human -DTXSID4040395 Css NA 0.08174 mg/L PBTK NA 95% Rat Human -DTXSID4040476 Clint NA 62.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040476 Fup NA 0.0211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040476 Vd NA 3.099 L/kg 1compartment NA NA Human Human -DTXSID4040476 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4040476 TK.Half.Life NA 29.77 hours 1compartment NA NA Human Human -DTXSID4040476 Css NA 1.108 mg/L 3compartmentss NA 50% Human Human -DTXSID4040476 Css NA 7.155 mg/L 3compartmentss NA 95% Human Human -DTXSID4040476 Css NA 0.7685 mg/L PBTK NA 50% Human Human -DTXSID4040476 Css NA 4.682 mg/L PBTK NA 95% Human Human -DTXSID4040476 Clint NA 62.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040476 Fup NA 0.0211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040476 Vd NA 2.321 L/kg 1compartment NA NA Rat Human -DTXSID4040476 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4040476 TK.Half.Life NA 4.458 hours 1compartment NA NA Rat Human -DTXSID4040476 Css NA 0.6264 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040476 Css NA 3.104 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040476 Css NA 0.4144 mg/L PBTK NA 50% Rat Human -DTXSID4040476 Css NA 1.978 mg/L PBTK NA 95% Rat Human -DTXSID4040682 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4040395 TK.Half.Life NA 0.6353 hours 1compartment NA NA Rat Human +DTXSID4040395 Css NA 0.00549 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040395 Css NA 0.03613 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040395 Css NA 0.004531 mg/L PBTK NA 50% Rat Human +DTXSID4040395 Css NA 0.02546 mg/L PBTK NA 95% Rat Human +DTXSID4040476 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040476 Fup 0.0128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040476 Vd NA 3.072 L/kg 1compartment NA NA Human Human +DTXSID4040476 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID4040476 TK.Half.Life NA 81.74 hours 1compartment NA NA Human Human +DTXSID4040476 Css NA 3.204 mg/L 3compartmentss NA 50% Human Human +DTXSID4040476 Css NA 21.11 mg/L 3compartmentss NA 95% Human Human +DTXSID4040476 Css NA 2.219 mg/L PBTK NA 50% Human Human +DTXSID4040476 Css NA 13.84 mg/L PBTK NA 95% Human Human +DTXSID4040476 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040476 Fup 0.0128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040476 Vd NA 2.301 L/kg 1compartment NA NA Rat Human +DTXSID4040476 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID4040476 TK.Half.Life NA 11.75 hours 1compartment NA NA Rat Human +DTXSID4040476 Css NA 0.4176 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040476 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040476 Css NA 0.2861 mg/L PBTK NA 50% Rat Human +DTXSID4040476 Css NA 1.488 mg/L PBTK NA 95% Rat Human +DTXSID4040680 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040680 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040680 Vd NA 0.8369 L/kg 1compartment NA NA Human Human +DTXSID4040680 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4040680 TK.Half.Life NA 9.849 hours 1compartment NA NA Human Human +DTXSID4040680 Css NA 1.264 mg/L 3compartmentss NA 50% Human Human +DTXSID4040680 Css NA 8.935 mg/L 3compartmentss NA 95% Human Human +DTXSID4040680 Css NA 1.022 mg/L PBTK NA 50% Human Human +DTXSID4040680 Css NA 5.64 mg/L PBTK NA 95% Human Human +DTXSID4040680 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040680 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040680 Vd NA 0.9378 L/kg 1compartment NA NA Rat Human +DTXSID4040680 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4040680 TK.Half.Life NA 2.891 hours 1compartment NA NA Rat Human +DTXSID4040680 Css NA 0.05965 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040680 Css NA 0.3939 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040680 Css NA 0.05134 mg/L PBTK NA 50% Rat Human +DTXSID4040680 Css NA 0.2454 mg/L PBTK NA 95% Rat Human +DTXSID4040682 Clint 10 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID4040682 Fup 0.086 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4040682 Vd NA 1.551 L/kg 1compartment NA NA Human Human -DTXSID4040682 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4040682 TK.Half.Life NA 17.81 hours 1compartment NA NA Human Human -DTXSID4040682 Css NA 1.676 mg/L 3compartmentss NA 50% Human Human -DTXSID4040682 Css NA 10.22 mg/L 3compartmentss NA 95% Human Human -DTXSID4040682 Css NA 1.106 mg/L PBTK NA 50% Human Human -DTXSID4040682 Css NA 6.246 mg/L PBTK NA 95% Human Human -DTXSID4040682 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4040682 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4040682 TK.Half.Life NA 9.042 hours 1compartment NA NA Human Human +DTXSID4040682 Css NA 0.77 mg/L 3compartmentss NA 50% Human Human +DTXSID4040682 Css NA 5.292 mg/L 3compartmentss NA 95% Human Human +DTXSID4040682 Css NA 0.505 mg/L PBTK NA 50% Human Human +DTXSID4040682 Css NA 3.306 mg/L PBTK NA 95% Human Human +DTXSID4040682 Clint 10 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID4040682 Fup 0.086 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4040682 Vd NA 1.18 L/kg 1compartment NA NA Rat Human DTXSID4040682 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040682 TK.Half.Life NA 6.533 hours 1compartment NA NA Rat Human -DTXSID4040682 Css NA 0.8688 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040682 Css NA 3.871 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040682 Css NA 0.5402 mg/L PBTK NA 50% Rat Human -DTXSID4040682 Css NA 2.224 mg/L PBTK NA 95% Rat Human -DTXSID4040684 Clint NA 116.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040684 Fup NA 0.053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040684 Vd NA 2.32 L/kg 1compartment NA NA Human Human +DTXSID4040682 TK.Half.Life NA 3.448 hours 1compartment NA NA Rat Human +DTXSID4040682 Css NA 0.0974 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040682 Css NA 0.4996 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040682 Css NA 0.06284 mg/L PBTK NA 50% Rat Human +DTXSID4040682 Css NA 0.3035 mg/L PBTK NA 95% Rat Human +DTXSID4040684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040684 Fup 0.026 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040684 Vd NA 1.585 L/kg 1compartment NA NA Human Human DTXSID4040684 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4040684 TK.Half.Life NA 2.619 hours 1compartment NA NA Human Human -DTXSID4040684 Css NA 0.06016 mg/L 3compartmentss NA 50% Human Human -DTXSID4040684 Css NA 0.5037 mg/L 3compartmentss NA 95% Human Human -DTXSID4040684 Css NA 0.04505 mg/L PBTK NA 50% Human Human -DTXSID4040684 Css NA 0.3388 mg/L PBTK NA 95% Human Human -DTXSID4040684 Clint NA 116.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040684 Fup NA 0.053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040684 Vd NA 2.067 L/kg 1compartment NA NA Rat Human +DTXSID4040684 TK.Half.Life NA 7.403 hours 1compartment NA NA Human Human +DTXSID4040684 Css NA 0.6224 mg/L 3compartmentss NA 50% Human Human +DTXSID4040684 Css NA 6.22 mg/L 3compartmentss NA 95% Human Human +DTXSID4040684 Css NA 0.421 mg/L PBTK NA 50% Human Human +DTXSID4040684 Css NA 3.808 mg/L PBTK NA 95% Human Human +DTXSID4040684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040684 Fup 0.026 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040684 Vd NA 1.394 L/kg 1compartment NA NA Rat Human DTXSID4040684 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040684 TK.Half.Life NA 1.128 hours 1compartment NA NA Rat Human -DTXSID4040684 Css NA 0.03335 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040684 Css NA 0.2493 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040684 Css NA 0.02383 mg/L PBTK NA 50% Rat Human -DTXSID4040684 Css NA 0.1595 mg/L PBTK NA 95% Rat Human +DTXSID4040684 TK.Half.Life NA 3.817 hours 1compartment NA NA Rat Human +DTXSID4040684 Css NA 0.0818 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040684 Css NA 0.6921 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040684 Css NA 0.05387 mg/L PBTK NA 50% Rat Human +DTXSID4040684 Css NA 0.4166 mg/L PBTK NA 95% Rat Human DTXSID4040686 Clint 26.48 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4040686 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4040686 Vd NA 0.1674 L/kg 1compartment NA NA Human Human DTXSID4040686 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID4040686 TK.Half.Life NA 12 hours 1compartment NA NA Human Human -DTXSID4040686 Css NA 8.537 mg/L 3compartmentss NA 50% Human Human -DTXSID4040686 Css NA 109.1 mg/L 3compartmentss NA 95% Human Human -DTXSID4040686 Css NA 7.912 mg/L PBTK NA 50% Human Human -DTXSID4040686 Css NA 76.24 mg/L PBTK NA 95% Human Human +DTXSID4040686 Css NA 7.807 mg/L 3compartmentss NA 50% Human Human +DTXSID4040686 Css NA 74.74 mg/L 3compartmentss NA 95% Human Human +DTXSID4040686 Css NA 7.806 mg/L PBTK NA 50% Human Human +DTXSID4040686 Css NA 74.74 mg/L PBTK NA 95% Human Human DTXSID4040686 Clint 26.48 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID4040686 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4040686 Vd NA 0.164 L/kg 1compartment NA NA Rat Human DTXSID4040686 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4040686 TK.Half.Life NA 8.039 hours 1compartment NA NA Rat Human -DTXSID4040686 Css NA 4.79 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040686 Css NA 47.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040686 Css NA 4.286 mg/L PBTK NA 50% Rat Human -DTXSID4040686 Css NA 31.18 mg/L PBTK NA 95% Rat Human -DTXSID4040688 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040688 Fup NA 0.2752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040688 Vd NA 0.3576 L/kg 1compartment NA NA Human Human -DTXSID4040688 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4040688 TK.Half.Life NA 8.408 hours 1compartment NA NA Human Human -DTXSID4040688 Css NA 2.886 mg/L 3compartmentss NA 50% Human Human -DTXSID4040688 Css NA 11.02 mg/L 3compartmentss NA 95% Human Human -DTXSID4040688 Css NA 1.917 mg/L PBTK NA 50% Human Human -DTXSID4040688 Css NA 6.707 mg/L PBTK NA 95% Human Human -DTXSID4040688 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040688 Fup NA 0.2752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040688 Vd NA 0.3747 L/kg 1compartment NA NA Rat Human -DTXSID4040688 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040688 TK.Half.Life NA 3.002 hours 1compartment NA NA Rat Human -DTXSID4040688 Css NA 0.7968 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040688 Css NA 2.576 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040688 Css NA 0.5032 mg/L PBTK NA 50% Rat Human -DTXSID4040688 Css NA 1.472 mg/L PBTK NA 95% Rat Human -DTXSID4040711 Clint NA 38.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040711 Fup NA 0.1911 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040711 Vd NA 1.825 L/kg 1compartment NA NA Human Human +DTXSID4040686 Css NA 0.9744 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040686 Css NA 7.676 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040686 Css NA 1.008 mg/L PBTK NA 50% Rat Human +DTXSID4040686 Css NA 7.951 mg/L PBTK NA 95% Rat Human +DTXSID4040711 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040711 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040711 Vd NA 1.663 L/kg 1compartment NA NA Human Human DTXSID4040711 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4040711 TK.Half.Life NA 2.679 hours 1compartment NA NA Human Human -DTXSID4040711 Css NA 0.0881 mg/L 3compartmentss NA 50% Human Human -DTXSID4040711 Css NA 0.6097 mg/L 3compartmentss NA 95% Human Human -DTXSID4040711 Css NA 0.06363 mg/L PBTK NA 50% Human Human -DTXSID4040711 Css NA 0.4093 mg/L PBTK NA 95% Human Human -DTXSID4040711 Clint NA 38.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040711 Fup NA 0.1911 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040711 Vd NA 1.414 L/kg 1compartment NA NA Rat Human +DTXSID4040711 TK.Half.Life NA 4.08 hours 1compartment NA NA Human Human +DTXSID4040711 Css NA 0.2382 mg/L 3compartmentss NA 50% Human Human +DTXSID4040711 Css NA 1.832 mg/L 3compartmentss NA 95% Human Human +DTXSID4040711 Css NA 0.1618 mg/L PBTK NA 50% Human Human +DTXSID4040711 Css NA 1.17 mg/L PBTK NA 95% Human Human +DTXSID4040711 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040711 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040711 Vd NA 1.278 L/kg 1compartment NA NA Rat Human DTXSID4040711 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040711 TK.Half.Life NA 0.9534 hours 1compartment NA NA Rat Human -DTXSID4040711 Css NA 0.04834 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040711 Css NA 0.2577 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040711 Css NA 0.03338 mg/L PBTK NA 50% Rat Human -DTXSID4040711 Css NA 0.17 mg/L PBTK NA 95% Rat Human -DTXSID4040715 Clint NA 30.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040715 Fup NA 0.2357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040715 Vd NA 1.87 L/kg 1compartment NA NA Human Human +DTXSID4040711 TK.Half.Life NA 1.519 hours 1compartment NA NA Rat Human +DTXSID4040711 Css NA 0.03015 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040711 Css NA 0.1819 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040711 Css NA 0.02021 mg/L PBTK NA 50% Rat Human +DTXSID4040711 Css NA 0.1149 mg/L PBTK NA 95% Rat Human +DTXSID4040715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040715 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040715 Vd NA 1.722 L/kg 1compartment NA NA Human Human DTXSID4040715 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4040715 TK.Half.Life NA 2.758 hours 1compartment NA NA Human Human -DTXSID4040715 Css NA 0.09096 mg/L 3compartmentss NA 50% Human Human -DTXSID4040715 Css NA 0.5914 mg/L 3compartmentss NA 95% Human Human -DTXSID4040715 Css NA 0.06678 mg/L PBTK NA 50% Human Human -DTXSID4040715 Css NA 0.4113 mg/L PBTK NA 95% Human Human -DTXSID4040715 Clint NA 30.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040715 Fup NA 0.2357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040715 Vd NA 1.459 L/kg 1compartment NA NA Rat Human +DTXSID4040715 TK.Half.Life NA 3.471 hours 1compartment NA NA Human Human +DTXSID4040715 Css NA 0.1528 mg/L 3compartmentss NA 50% Human Human +DTXSID4040715 Css NA 1.003 mg/L 3compartmentss NA 95% Human Human +DTXSID4040715 Css NA 0.1088 mg/L PBTK NA 50% Human Human +DTXSID4040715 Css NA 0.6759 mg/L PBTK NA 95% Human Human +DTXSID4040715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040715 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040715 Vd NA 1.337 L/kg 1compartment NA NA Rat Human DTXSID4040715 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040715 TK.Half.Life NA 0.9818 hours 1compartment NA NA Rat Human -DTXSID4040715 Css NA 0.0497 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040715 Css NA 0.2556 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040715 Css NA 0.0352 mg/L PBTK NA 50% Rat Human -DTXSID4040715 Css NA 0.1703 mg/L PBTK NA 95% Rat Human -DTXSID4040719 Clint NA 3.628 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040719 Fup NA 0.345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040719 Vd NA 0.7404 L/kg 1compartment NA NA Human Human +DTXSID4040715 TK.Half.Life NA 1.282 hours 1compartment NA NA Rat Human +DTXSID4040715 Css NA 0.01921 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040715 Css NA 0.09689 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040715 Css NA 0.01357 mg/L PBTK NA 50% Rat Human +DTXSID4040715 Css NA 0.06596 mg/L PBTK NA 95% Rat Human +DTXSID4040719 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040719 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040719 Vd NA 0.8575 L/kg 1compartment NA NA Human Human DTXSID4040719 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4040719 TK.Half.Life NA 2.406 hours 1compartment NA NA Human Human -DTXSID4040719 Css NA 0.3148 mg/L 3compartmentss NA 50% Human Human -DTXSID4040719 Css NA 1.824 mg/L 3compartmentss NA 95% Human Human -DTXSID4040719 Css NA 0.2325 mg/L PBTK NA 50% Human Human -DTXSID4040719 Css NA 1.208 mg/L PBTK NA 95% Human Human -DTXSID4040719 Clint NA 3.628 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040719 Fup NA 0.345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040719 Vd NA 0.6863 L/kg 1compartment NA NA Rat Human +DTXSID4040719 TK.Half.Life NA 1.165 hours 1compartment NA NA Human Human +DTXSID4040719 Css NA 0.07242 mg/L 3compartmentss NA 50% Human Human +DTXSID4040719 Css NA 0.5375 mg/L 3compartmentss NA 95% Human Human +DTXSID4040719 Css NA 0.05237 mg/L PBTK NA 50% Human Human +DTXSID4040719 Css NA 0.3589 mg/L PBTK NA 95% Human Human +DTXSID4040719 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040719 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040719 Vd NA 0.7515 L/kg 1compartment NA NA Rat Human DTXSID4040719 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040719 TK.Half.Life NA 1.236 hours 1compartment NA NA Rat Human -DTXSID4040719 Css NA 0.1522 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040719 Css NA 0.6616 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040719 Css NA 0.1083 mg/L PBTK NA 50% Rat Human -DTXSID4040719 Css NA 0.4094 mg/L PBTK NA 95% Rat Human -DTXSID4040765 Clint NA 449.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040765 Fup NA 0.9018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040765 Vd NA 0.9435 L/kg 1compartment NA NA Human Human +DTXSID4040719 TK.Half.Life NA 0.5377 hours 1compartment NA NA Rat Human +DTXSID4040719 Css NA 0.00924 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040719 Css NA 0.05295 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040719 Css NA 0.006663 mg/L PBTK NA 50% Rat Human +DTXSID4040719 Css NA 0.03431 mg/L PBTK NA 95% Rat Human +DTXSID4040761 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040761 Fup 0.00426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040761 Vd NA 1.164 L/kg 1compartment NA NA Human Human +DTXSID4040761 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4040761 TK.Half.Life NA 31.58 hours 1compartment NA NA Human Human +DTXSID4040761 Css NA 4.676 mg/L 3compartmentss NA 50% Human Human +DTXSID4040761 Css NA 42.79 mg/L 3compartmentss NA 95% Human Human +DTXSID4040761 Css NA 2.844 mg/L PBTK NA 50% Human Human +DTXSID4040761 Css NA 25.39 mg/L PBTK NA 95% Human Human +DTXSID4040761 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040761 Fup 0.00426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040761 Vd NA 0.8535 L/kg 1compartment NA NA Rat Human +DTXSID4040761 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4040761 TK.Half.Life NA 13.4 hours 1compartment NA NA Rat Human +DTXSID4040761 Css NA 0.6202 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040761 Css NA 4.593 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040761 Css NA 0.3624 mg/L PBTK NA 50% Rat Human +DTXSID4040761 Css NA 2.623 mg/L PBTK NA 95% Rat Human +DTXSID4040763 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040763 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040763 Vd NA 0.5143 L/kg 1compartment NA NA Human Human +DTXSID4040763 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4040763 TK.Half.Life NA 6.436 hours 1compartment NA NA Human Human +DTXSID4040763 Css NA 1.408 mg/L 3compartmentss NA 50% Human Human +DTXSID4040763 Css NA 7.784 mg/L 3compartmentss NA 95% Human Human +DTXSID4040763 Css NA 1.057 mg/L PBTK NA 50% Human Human +DTXSID4040763 Css NA 4.864 mg/L PBTK NA 95% Human Human +DTXSID4040763 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040763 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040763 Vd NA 0.5403 L/kg 1compartment NA NA Rat Human +DTXSID4040763 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4040763 TK.Half.Life NA 2.304 hours 1compartment NA NA Rat Human +DTXSID4040763 Css NA 0.08843 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040763 Css NA 0.4196 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040763 Css NA 0.06533 mg/L PBTK NA 50% Rat Human +DTXSID4040763 Css NA 0.2539 mg/L PBTK NA 95% Rat Human +DTXSID4040765 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040765 Fup 0.772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040765 Vd NA 0.8574 L/kg 1compartment NA NA Human Human DTXSID4040765 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4040765 TK.Half.Life NA 0.5271 hours 1compartment NA NA Human Human -DTXSID4040765 Css NA 0.001208 mg/L 3compartmentss NA 50% Human Human -DTXSID4040765 Css NA 0.01012 mg/L 3compartmentss NA 95% Human Human -DTXSID4040765 Css NA 0.001021 mg/L PBTK NA 50% Human Human -DTXSID4040765 Css NA 0.007732 mg/L PBTK NA 95% Human Human -DTXSID4040765 Clint NA 449.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040765 Fup NA 0.9018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040765 Vd NA 0.9441 L/kg 1compartment NA NA Rat Human +DTXSID4040765 TK.Half.Life NA 0.6743 hours 1compartment NA NA Human Human +DTXSID4040765 Css NA 0.02623 mg/L 3compartmentss NA 50% Human Human +DTXSID4040765 Css NA 0.2925 mg/L 3compartmentss NA 95% Human Human +DTXSID4040765 Css NA 0.02179 mg/L PBTK NA 50% Human Human +DTXSID4040765 Css NA 0.2034 mg/L PBTK NA 95% Human Human +DTXSID4040765 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040765 Fup 0.772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040765 Vd NA 0.8575 L/kg 1compartment NA NA Rat Human DTXSID4040765 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040765 TK.Half.Life NA 0.2282 hours 1compartment NA NA Rat Human -DTXSID4040765 Css NA 0.000629 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040765 Css NA 0.004661 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040765 Css NA 0.0005324 mg/L PBTK NA 50% Rat Human -DTXSID4040765 Css NA 0.003569 mg/L PBTK NA 95% Rat Human +DTXSID4040765 TK.Half.Life NA 0.3277 hours 1compartment NA NA Rat Human +DTXSID4040765 Css NA 0.003136 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040765 Css NA 0.0291 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040765 Css NA 0.002672 mg/L PBTK NA 50% Rat Human +DTXSID4040765 Css NA 0.01986 mg/L PBTK NA 95% Rat Human DTXSID4040767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4040767 Fup 9.31e-09 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4040767 Vd NA 0.2109 L/kg 1compartment NA NA Human Human +DTXSID4040767 Vd NA 0.2048 L/kg 1compartment NA NA Human Human DTXSID4040767 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4040767 TK.Half.Life NA 13650 hours 1compartment NA NA Human Human -DTXSID4040767 Css NA 5541 mg/L 3compartmentss NA 50% Human Human -DTXSID4040767 Css NA 13950 mg/L 3compartmentss NA 95% Human Human -DTXSID4040767 Css NA 3240 mg/L PBTK NA 50% Human Human -DTXSID4040767 Css NA 7881 mg/L PBTK NA 95% Human Human +DTXSID4040767 TK.Half.Life NA 13260 hours 1compartment NA NA Human Human +DTXSID4040767 Css NA 5346 mg/L 3compartmentss NA 50% Human Human +DTXSID4040767 Css NA 13540 mg/L 3compartmentss NA 95% Human Human +DTXSID4040767 Css NA 3118 mg/L PBTK NA 50% Human Human +DTXSID4040767 Css NA 7681 mg/L PBTK NA 95% Human Human DTXSID4040767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4040767 Fup 9.31e-09 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4040767 Vd NA 0.1847 L/kg 1compartment NA NA Rat Human -DTXSID4040767 Days.Css NA 1124 Days PBTK NA NA Rat Human -DTXSID4040767 TK.Half.Life NA 4073 hours 1compartment NA NA Rat Human -DTXSID4040767 Css NA 1893 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040767 Css NA 2452 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040767 Css NA 1024 mg/L PBTK NA 50% Rat Human -DTXSID4040767 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID4040979 Clint NA 138.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040979 Fup NA 0.0459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4040979 Vd NA 1.268 L/kg 1compartment NA NA Human Human +DTXSID4040767 Vd NA 0.1814 L/kg 1compartment NA NA Rat Human +DTXSID4040767 Days.Css NA 1102 Days PBTK NA NA Rat Human +DTXSID4040767 TK.Half.Life NA 4000 hours 1compartment NA NA Rat Human +DTXSID4040767 Css NA 421 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040767 Css NA 555.8 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040767 Css NA 235.7 mg/L PBTK NA 50% Rat Human +DTXSID4040767 Css NA 311.2 mg/L PBTK NA 95% Rat Human +DTXSID4040979 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040979 Fup 0.0823 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4040979 Vd NA 1.442 L/kg 1compartment NA NA Human Human DTXSID4040979 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4040979 TK.Half.Life NA 1.707 hours 1compartment NA NA Human Human -DTXSID4040979 Css NA 0.08637 mg/L 3compartmentss NA 50% Human Human -DTXSID4040979 Css NA 0.7459 mg/L 3compartmentss NA 95% Human Human -DTXSID4040979 Css NA 0.05766 mg/L PBTK NA 50% Human Human -DTXSID4040979 Css NA 0.4632 mg/L PBTK NA 95% Human Human -DTXSID4040979 Clint NA 138.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040979 Fup NA 0.0459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4040979 Vd NA 1.15 L/kg 1compartment NA NA Rat Human +DTXSID4040979 TK.Half.Life NA 3.866 hours 1compartment NA NA Human Human +DTXSID4040979 Css NA 0.2484 mg/L 3compartmentss NA 50% Human Human +DTXSID4040979 Css NA 2.205 mg/L 3compartmentss NA 95% Human Human +DTXSID4040979 Css NA 0.1747 mg/L PBTK NA 50% Human Human +DTXSID4040979 Css NA 1.435 mg/L PBTK NA 95% Human Human +DTXSID4040979 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040979 Fup 0.0823 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4040979 Vd NA 1.359 L/kg 1compartment NA NA Rat Human DTXSID4040979 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4040979 TK.Half.Life NA 0.8092 hours 1compartment NA NA Rat Human -DTXSID4040979 Css NA 0.04972 mg/L 3compartmentss NA 50% Rat Human -DTXSID4040979 Css NA 0.3445 mg/L 3compartmentss NA 95% Rat Human -DTXSID4040979 Css NA 0.03118 mg/L PBTK NA 50% Rat Human -DTXSID4040979 Css NA 0.2039 mg/L PBTK NA 95% Rat Human +DTXSID4040979 TK.Half.Life NA 2.15 hours 1compartment NA NA Rat Human +DTXSID4040979 Css NA 0.0121 mg/L 3compartmentss NA 50% Rat Human +DTXSID4040979 Css NA 0.1116 mg/L 3compartmentss NA 95% Rat Human +DTXSID4040979 Css NA 0.008426 mg/L PBTK NA 50% Rat Human +DTXSID4040979 Css NA 0.06907 mg/L PBTK NA 95% Rat Human DTXSID4041070 Clint 14.79 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4041070 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4041070 Vd NA 1.133 L/kg 1compartment NA NA Human Human -DTXSID4041070 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4041070 TK.Half.Life NA 14.18 hours 1compartment NA NA Human Human -DTXSID4041070 Css NA 2.097 mg/L 3compartmentss NA 50% Human Human -DTXSID4041070 Css NA 18.72 mg/L 3compartmentss NA 95% Human Human -DTXSID4041070 Css NA 1.294 mg/L PBTK NA 50% Human Human -DTXSID4041070 Css NA 11.09 mg/L PBTK NA 95% Human Human +DTXSID4041070 Vd NA 0.3564 L/kg 1compartment NA NA Human Human +DTXSID4041070 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4041070 TK.Half.Life NA 4.596 hours 1compartment NA NA Human Human +DTXSID4041070 Css NA 2.239 mg/L 3compartmentss NA 50% Human Human +DTXSID4041070 Css NA 21.26 mg/L 3compartmentss NA 95% Human Human +DTXSID4041070 Css NA 1.322 mg/L PBTK NA 50% Human Human +DTXSID4041070 Css NA 12.3 mg/L PBTK NA 95% Human Human DTXSID4041070 Clint 14.79 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4041070 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4041070 Vd NA 0.8402 L/kg 1compartment NA NA Rat Human +DTXSID4041070 Vd NA 0.2922 L/kg 1compartment NA NA Rat Human DTXSID4041070 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041070 TK.Half.Life NA 6.006 hours 1compartment NA NA Rat Human -DTXSID4041070 Css NA 1.182 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041070 Css NA 8.161 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041070 Css NA 0.6776 mg/L PBTK NA 50% Rat Human -DTXSID4041070 Css NA 4.568 mg/L PBTK NA 95% Rat Human -DTXSID4041074 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041074 Fup NA 0.9926 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041074 Vd NA 0.6541 L/kg 1compartment NA NA Human Human -DTXSID4041074 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041074 TK.Half.Life NA 4.266 hours 1compartment NA NA Human Human -DTXSID4041074 Css NA 0.8966 mg/L 3compartmentss NA 50% Human Human -DTXSID4041074 Css NA 5.192 mg/L 3compartmentss NA 95% Human Human -DTXSID4041074 Css NA 0.7268 mg/L PBTK NA 50% Human Human -DTXSID4041074 Css NA 3.33 mg/L PBTK NA 95% Human Human -DTXSID4041074 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041074 Fup NA 0.9926 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041074 Vd NA 0.7127 L/kg 1compartment NA NA Rat Human -DTXSID4041074 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041074 TK.Half.Life NA 1.583 hours 1compartment NA NA Rat Human -DTXSID4041074 Css NA 0.2293 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041074 Css NA 1.241 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041074 Css NA 0.18 mg/L PBTK NA 50% Rat Human -DTXSID4041074 Css NA 0.7436 mg/L PBTK NA 95% Rat Human -DTXSID4041230 Clint NA 18.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041230 Fup NA 0.9791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041230 Vd NA 0.8837 L/kg 1compartment NA NA Human Human +DTXSID4041070 TK.Half.Life NA 2.448 hours 1compartment NA NA Rat Human +DTXSID4041070 Css NA 0.2847 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041070 Css NA 2.181 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041070 Css NA 0.1626 mg/L PBTK NA 50% Rat Human +DTXSID4041070 Css NA 1.232 mg/L PBTK NA 95% Rat Human +DTXSID4041155 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041155 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4041155 Vd NA 0.5733 L/kg 1compartment NA NA Human Human +DTXSID4041155 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4041155 TK.Half.Life NA 2.013 hours 1compartment NA NA Human Human +DTXSID4041155 Css NA 0.345 mg/L 3compartmentss NA 50% Human Human +DTXSID4041155 Css NA 2.05 mg/L 3compartmentss NA 95% Human Human +DTXSID4041155 Css NA 0.2386 mg/L PBTK NA 50% Human Human +DTXSID4041155 Css NA 1.319 mg/L PBTK NA 95% Human Human +DTXSID4041155 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041155 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4041155 Vd NA 0.5483 L/kg 1compartment NA NA Rat Human +DTXSID4041155 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4041155 TK.Half.Life NA 1.129 hours 1compartment NA NA Rat Human +DTXSID4041155 Css NA 0.04055 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041155 Css NA 0.1763 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041155 Css NA 0.02784 mg/L PBTK NA 50% Rat Human +DTXSID4041155 Css NA 0.1108 mg/L PBTK NA 95% Rat Human +DTXSID4041230 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041230 Fup 0.661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041230 Vd NA 0.6983 L/kg 1compartment NA NA Human Human DTXSID4041230 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041230 TK.Half.Life NA 0.6412 hours 1compartment NA NA Human Human -DTXSID4041230 Css NA 0.0294 mg/L 3compartmentss NA 50% Human Human -DTXSID4041230 Css NA 0.2849 mg/L 3compartmentss NA 95% Human Human -DTXSID4041230 Css NA 0.02463 mg/L PBTK NA 50% Human Human -DTXSID4041230 Css NA 0.2085 mg/L PBTK NA 95% Human Human -DTXSID4041230 Clint NA 18.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041230 Fup NA 0.9791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041230 Vd NA 0.8955 L/kg 1compartment NA NA Rat Human +DTXSID4041230 TK.Half.Life NA 6.863 hours 1compartment NA NA Human Human +DTXSID4041230 Css NA 1.104 mg/L 3compartmentss NA 50% Human Human +DTXSID4041230 Css NA 7.255 mg/L 3compartmentss NA 95% Human Human +DTXSID4041230 Css NA 0.8892 mg/L PBTK NA 50% Human Human +DTXSID4041230 Css NA 4.574 mg/L PBTK NA 95% Human Human +DTXSID4041230 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041230 Fup 0.661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041230 Vd NA 0.7063 L/kg 1compartment NA NA Rat Human DTXSID4041230 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041230 TK.Half.Life NA 0.3134 hours 1compartment NA NA Rat Human -DTXSID4041230 Css NA 0.01458 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041230 Css NA 0.1269 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041230 Css NA 0.0121 mg/L PBTK NA 50% Rat Human -DTXSID4041230 Css NA 0.08556 mg/L PBTK NA 95% Rat Human -DTXSID4041234 Clint NA 0.8365 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041234 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041234 Vd NA 1.038 L/kg 1compartment NA NA Human Human -DTXSID4041234 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041234 TK.Half.Life NA 3.043 hours 1compartment NA NA Human Human -DTXSID4041234 Css NA 0.3262 mg/L 3compartmentss NA 50% Human Human -DTXSID4041234 Css NA 2.352 mg/L 3compartmentss NA 95% Human Human -DTXSID4041234 Css NA 0.2928 mg/L PBTK NA 50% Human Human -DTXSID4041234 Css NA 1.597 mg/L PBTK NA 95% Human Human -DTXSID4041234 Clint NA 0.8365 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041234 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041234 Vd NA 1.033 L/kg 1compartment NA NA Rat Human +DTXSID4041230 TK.Half.Life NA 2.358 hours 1compartment NA NA Rat Human +DTXSID4041230 Css NA 0.0669 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041230 Css NA 0.4147 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041230 Css NA 0.0535 mg/L PBTK NA 50% Rat Human +DTXSID4041230 Css NA 0.2531 mg/L PBTK NA 95% Rat Human +DTXSID4041234 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041234 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041234 Vd NA 1.078 L/kg 1compartment NA NA Human Human +DTXSID4041234 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4041234 TK.Half.Life NA 15.59 hours 1compartment NA NA Human Human +DTXSID4041234 Css NA 1.446 mg/L 3compartmentss NA 50% Human Human +DTXSID4041234 Css NA 7.098 mg/L 3compartmentss NA 95% Human Human +DTXSID4041234 Css NA 1.176 mg/L PBTK NA 50% Human Human +DTXSID4041234 Css NA 4.649 mg/L PBTK NA 95% Human Human +DTXSID4041234 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041234 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041234 Vd NA 0.9636 L/kg 1compartment NA NA Rat Human DTXSID4041234 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041234 TK.Half.Life NA 1.405 hours 1compartment NA NA Rat Human -DTXSID4041234 Css NA 0.1184 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041234 Css NA 0.7995 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041234 Css NA 0.1049 mg/L PBTK NA 50% Rat Human -DTXSID4041234 Css NA 0.4899 mg/L PBTK NA 95% Rat Human +DTXSID4041234 TK.Half.Life NA 4.498 hours 1compartment NA NA Rat Human +DTXSID4041234 Css NA 0.0915 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041234 Css NA 0.3964 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041234 Css NA 0.07431 mg/L PBTK NA 50% Rat Human +DTXSID4041234 Css NA 0.2514 mg/L PBTK NA 95% Rat Human DTXSID4041238 Clint NA 25.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4041238 Fup NA 0.7031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041238 Vd NA 2.342 L/kg 1compartment NA NA Human Human +DTXSID4041238 Vd NA 2.146 L/kg 1compartment NA NA Human Human DTXSID4041238 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041238 TK.Half.Life NA 1.503 hours 1compartment NA NA Human Human -DTXSID4041238 Css NA 0.02022 mg/L 3compartmentss NA 50% Human Human -DTXSID4041238 Css NA 0.2348 mg/L 3compartmentss NA 95% Human Human -DTXSID4041238 Css NA 0.02187 mg/L PBTK NA 50% Human Human -DTXSID4041238 Css NA 0.189 mg/L PBTK NA 95% Human Human +DTXSID4041238 TK.Half.Life NA 1.414 hours 1compartment NA NA Human Human +DTXSID4041238 Css NA 0.01886 mg/L 3compartmentss NA 50% Human Human +DTXSID4041238 Css NA 0.2439 mg/L 3compartmentss NA 95% Human Human +DTXSID4041238 Css NA 0.01953 mg/L PBTK NA 50% Human Human +DTXSID4041238 Css NA 0.1939 mg/L PBTK NA 95% Human Human DTXSID4041238 Clint NA 25.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4041238 Fup NA 0.7031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041238 Vd NA 2.34 L/kg 1compartment NA NA Rat Human +DTXSID4041238 Vd NA 2.144 L/kg 1compartment NA NA Rat Human DTXSID4041238 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041238 TK.Half.Life NA 0.7537 hours 1compartment NA NA Rat Human -DTXSID4041238 Css NA 0.01 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041238 Css NA 0.1111 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041238 Css NA 0.01092 mg/L PBTK NA 50% Rat Human -DTXSID4041238 Css NA 0.07973 mg/L PBTK NA 95% Rat Human +DTXSID4041238 TK.Half.Life NA 0.7064 hours 1compartment NA NA Rat Human +DTXSID4041238 Css NA 0.002231 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041238 Css NA 0.02437 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041238 Css NA 0.002434 mg/L PBTK NA 50% Rat Human +DTXSID4041238 Css NA 0.01888 mg/L PBTK NA 95% Rat Human DTXSID4041280 Clint 10.4 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID4041280 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID4041280 Vd NA 1.527 L/kg 1compartment NA NA Human Human +DTXSID4041280 Vd NA 1.323 L/kg 1compartment NA NA Human Human DTXSID4041280 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041280 TK.Half.Life NA 1.233 hours 1compartment NA NA Human Human -DTXSID4041280 Css NA 0.03889 mg/L 3compartmentss NA 50% Human Human -DTXSID4041280 Css NA 0.2183 mg/L 3compartmentss NA 95% Human Human -DTXSID4041280 Css NA 0.03708 mg/L PBTK NA 50% Human Human -DTXSID4041280 Css NA 0.1917 mg/L PBTK NA 95% Human Human +DTXSID4041280 TK.Half.Life NA 1.072 hours 1compartment NA NA Human Human +DTXSID4041280 Css NA 0.03716 mg/L 3compartmentss NA 50% Human Human +DTXSID4041280 Css NA 0.2167 mg/L 3compartmentss NA 95% Human Human +DTXSID4041280 Css NA 0.03432 mg/L PBTK NA 50% Human Human +DTXSID4041280 Css NA 0.184 mg/L PBTK NA 95% Human Human DTXSID4041280 Clint 10.4 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID4041280 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID4041280 Vd NA 1.474 L/kg 1compartment NA NA Rat Human +DTXSID4041280 Vd NA 1.308 L/kg 1compartment NA NA Rat Human DTXSID4041280 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041280 TK.Half.Life NA 0.597 hours 1compartment NA NA Rat Human -DTXSID4041280 Css NA 0.01915 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041280 Css NA 0.08522 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041280 Css NA 0.01838 mg/L PBTK NA 50% Rat Human -DTXSID4041280 Css NA 0.07497 mg/L PBTK NA 95% Rat Human -DTXSID4041361 Clint NA 5.521 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041361 Fup NA 0.1256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041361 Vd NA 1.538 L/kg 1compartment NA NA Human Human +DTXSID4041280 TK.Half.Life NA 0.5344 hours 1compartment NA NA Rat Human +DTXSID4041280 Css NA 0.004292 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041280 Css NA 0.01881 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041280 Css NA 0.004127 mg/L PBTK NA 50% Rat Human +DTXSID4041280 Css NA 0.01676 mg/L PBTK NA 95% Rat Human +DTXSID4041317 Clint NA 0.1364 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4041317 Fup NA 0.0444 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4041317 Vd NA 0.3344 L/kg 1compartment NA NA Human Human +DTXSID4041317 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4041317 TK.Half.Life NA 39.77 hours 1compartment NA NA Human Human +DTXSID4041317 Css NA 16.14 mg/L 3compartmentss NA 50% Human Human +DTXSID4041317 Css NA 87.73 mg/L 3compartmentss NA 95% Human Human +DTXSID4041317 Css NA 9.944 mg/L PBTK NA 50% Human Human +DTXSID4041317 Css NA 51.15 mg/L PBTK NA 95% Human Human +DTXSID4041317 Clint NA 0.1364 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4041317 Fup NA 0.0444 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4041317 Vd NA 0.3261 L/kg 1compartment NA NA Rat Human +DTXSID4041317 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4041317 TK.Half.Life NA 14.59 hours 1compartment NA NA Rat Human +DTXSID4041317 Css NA 0.3393 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041317 Css NA 2.44 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041317 Css NA 0.1998 mg/L PBTK NA 50% Rat Human +DTXSID4041317 Css NA 1.39 mg/L PBTK NA 95% Rat Human +DTXSID4041361 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041361 Fup 0.0587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041361 Vd NA 1.078 L/kg 1compartment NA NA Human Human DTXSID4041361 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041361 TK.Half.Life NA 10.49 hours 1compartment NA NA Human Human -DTXSID4041361 Css NA 0.9116 mg/L 3compartmentss NA 50% Human Human -DTXSID4041361 Css NA 5.883 mg/L 3compartmentss NA 95% Human Human -DTXSID4041361 Css NA 0.6128 mg/L PBTK NA 50% Human Human -DTXSID4041361 Css NA 3.644 mg/L PBTK NA 95% Human Human -DTXSID4041361 Clint NA 5.521 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041361 Fup NA 0.1256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041361 Vd NA 1.185 L/kg 1compartment NA NA Rat Human +DTXSID4041361 TK.Half.Life NA 4.193 hours 1compartment NA NA Human Human +DTXSID4041361 Css NA 0.51 mg/L 3compartmentss NA 50% Human Human +DTXSID4041361 Css NA 3.884 mg/L 3compartmentss NA 95% Human Human +DTXSID4041361 Css NA 0.3215 mg/L PBTK NA 50% Human Human +DTXSID4041361 Css NA 2.362 mg/L PBTK NA 95% Human Human +DTXSID4041361 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041361 Fup 0.0587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041361 Vd NA 0.8243 L/kg 1compartment NA NA Rat Human DTXSID4041361 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041361 TK.Half.Life NA 3.977 hours 1compartment NA NA Rat Human -DTXSID4041361 Css NA 0.4753 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041361 Css NA 2.167 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041361 Css NA 0.3049 mg/L PBTK NA 50% Rat Human -DTXSID4041361 Css NA 1.274 mg/L PBTK NA 95% Rat Human +DTXSID4041361 TK.Half.Life NA 1.803 hours 1compartment NA NA Rat Human +DTXSID4041361 Css NA 0.06575 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041361 Css NA 0.409 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041361 Css NA 0.04036 mg/L PBTK NA 50% Rat Human +DTXSID4041361 Css NA 0.2398 mg/L PBTK NA 95% Rat Human DTXSID4041363 Clint NA 2.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4041363 Fup NA 0.0256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041363 Vd NA 0.2269 L/kg 1compartment NA NA Human Human -DTXSID4041363 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4041363 TK.Half.Life NA 9.854 hours 1compartment NA NA Human Human -DTXSID4041363 Css NA 7.828 mg/L 3compartmentss NA 50% Human Human -DTXSID4041363 Css NA 60.14 mg/L 3compartmentss NA 95% Human Human -DTXSID4041363 Css NA 4.659 mg/L PBTK NA 50% Human Human -DTXSID4041363 Css NA 34.92 mg/L PBTK NA 95% Human Human +DTXSID4041363 Vd NA 0.1926 L/kg 1compartment NA NA Human Human +DTXSID4041363 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4041363 TK.Half.Life NA 8.241 hours 1compartment NA NA Human Human +DTXSID4041363 Css NA 7.676 mg/L 3compartmentss NA 50% Human Human +DTXSID4041363 Css NA 56.56 mg/L 3compartmentss NA 95% Human Human +DTXSID4041363 Css NA 4.539 mg/L PBTK NA 50% Human Human +DTXSID4041363 Css NA 32.75 mg/L PBTK NA 95% Human Human DTXSID4041363 Clint NA 2.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4041363 Fup NA 0.0256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041363 Vd NA 0.2218 L/kg 1compartment NA NA Rat Human +DTXSID4041363 Vd NA 0.1911 L/kg 1compartment NA NA Rat Human DTXSID4041363 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041363 TK.Half.Life NA 5.696 hours 1compartment NA NA Rat Human -DTXSID4041363 Css NA 3.853 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041363 Css NA 23.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041363 Css NA 2.141 mg/L PBTK NA 50% Rat Human -DTXSID4041363 Css NA 12.73 mg/L PBTK NA 95% Rat Human +DTXSID4041363 TK.Half.Life NA 4.84 hours 1compartment NA NA Rat Human +DTXSID4041363 Css NA 0.876 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041363 Css NA 5.475 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041363 Css NA 0.4989 mg/L PBTK NA 50% Rat Human +DTXSID4041363 Css NA 3.074 mg/L PBTK NA 95% Rat Human DTXSID4041367 Clint NA 1.531 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4041367 Fup NA 0.2932 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041367 Vd NA 0.6116 L/kg 1compartment NA NA Human Human +DTXSID4041367 Vd NA 0.6417 L/kg 1compartment NA NA Human Human DTXSID4041367 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041367 TK.Half.Life NA 4.08 hours 1compartment NA NA Human Human -DTXSID4041367 Css NA 0.7403 mg/L 3compartmentss NA 50% Human Human -DTXSID4041367 Css NA 3.635 mg/L 3compartmentss NA 95% Human Human -DTXSID4041367 Css NA 0.5294 mg/L PBTK NA 50% Human Human -DTXSID4041367 Css NA 2.317 mg/L PBTK NA 95% Human Human +DTXSID4041367 TK.Half.Life NA 4.289 hours 1compartment NA NA Human Human +DTXSID4041367 Css NA 0.72 mg/L 3compartmentss NA 50% Human Human +DTXSID4041367 Css NA 3.445 mg/L 3compartmentss NA 95% Human Human +DTXSID4041367 Css NA 0.5168 mg/L PBTK NA 50% Human Human +DTXSID4041367 Css NA 2.213 mg/L PBTK NA 95% Human Human DTXSID4041367 Clint NA 1.531 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4041367 Fup NA 0.2932 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041367 Vd NA 0.5791 L/kg 1compartment NA NA Rat Human +DTXSID4041367 Vd NA 0.6008 L/kg 1compartment NA NA Rat Human DTXSID4041367 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041367 TK.Half.Life NA 2.006 hours 1compartment NA NA Rat Human -DTXSID4041367 Css NA 0.3226 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041367 Css NA 1.19 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041367 Css NA 0.2191 mg/L PBTK NA 50% Rat Human -DTXSID4041367 Css NA 0.7067 mg/L PBTK NA 95% Rat Human -DTXSID4041442 Clint NA 5.219 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041442 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041442 Vd NA 0.2487 L/kg 1compartment NA NA Human Human +DTXSID4041367 TK.Half.Life NA 2.08 hours 1compartment NA NA Rat Human +DTXSID4041367 Css NA 0.07228 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041367 Css NA 0.2719 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041367 Css NA 0.05118 mg/L PBTK NA 50% Rat Human +DTXSID4041367 Css NA 0.1668 mg/L PBTK NA 95% Rat Human +DTXSID4041442 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041442 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041442 Vd NA 0.335 L/kg 1compartment NA NA Human Human DTXSID4041442 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041442 TK.Half.Life NA 2.704 hours 1compartment NA NA Human Human -DTXSID4041442 Css NA 1.807 mg/L 3compartmentss NA 50% Human Human -DTXSID4041442 Css NA 11.45 mg/L 3compartmentss NA 95% Human Human -DTXSID4041442 Css NA 1.092 mg/L PBTK NA 50% Human Human -DTXSID4041442 Css NA 6.733 mg/L PBTK NA 95% Human Human -DTXSID4041442 Clint NA 5.219 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041442 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041442 Vd NA 0.2494 L/kg 1compartment NA NA Rat Human +DTXSID4041442 TK.Half.Life NA 1.042 hours 1compartment NA NA Human Human +DTXSID4041442 Css NA 0.3054 mg/L 3compartmentss NA 50% Human Human +DTXSID4041442 Css NA 1.819 mg/L 3compartmentss NA 95% Human Human +DTXSID4041442 Css NA 0.1988 mg/L PBTK NA 50% Human Human +DTXSID4041442 Css NA 1.133 mg/L PBTK NA 95% Human Human +DTXSID4041442 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041442 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041442 Vd NA 0.3466 L/kg 1compartment NA NA Rat Human DTXSID4041442 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041442 TK.Half.Life NA 1.669 hours 1compartment NA NA Rat Human -DTXSID4041442 Css NA 0.9448 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041442 Css NA 4.398 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041442 Css NA 0.5336 mg/L PBTK NA 50% Rat Human -DTXSID4041442 Css NA 2.407 mg/L PBTK NA 95% Rat Human -DTXSID4041446 Clint NA 8.792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041446 Fup NA 0.1674 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041446 Vd NA 2.062 L/kg 1compartment NA NA Human Human +DTXSID4041442 TK.Half.Life NA 0.6319 hours 1compartment NA NA Rat Human +DTXSID4041442 Css NA 0.03709 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041442 Css NA 0.1609 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041442 Css NA 0.02358 mg/L PBTK NA 50% Rat Human +DTXSID4041442 Css NA 0.09785 mg/L PBTK NA 95% Rat Human +DTXSID4041446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041446 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041446 Vd NA 1.911 L/kg 1compartment NA NA Human Human DTXSID4041446 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041446 TK.Half.Life NA 9.422 hours 1compartment NA NA Human Human -DTXSID4041446 Css NA 0.504 mg/L 3compartmentss NA 50% Human Human -DTXSID4041446 Css NA 3.005 mg/L 3compartmentss NA 95% Human Human -DTXSID4041446 Css NA 0.3594 mg/L PBTK NA 50% Human Human -DTXSID4041446 Css NA 2.005 mg/L PBTK NA 95% Human Human -DTXSID4041446 Clint NA 8.792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041446 Fup NA 0.1674 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041446 Vd NA 1.58 L/kg 1compartment NA NA Rat Human +DTXSID4041446 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human +DTXSID4041446 Css NA 0.3416 mg/L 3compartmentss NA 50% Human Human +DTXSID4041446 Css NA 2.532 mg/L 3compartmentss NA 95% Human Human +DTXSID4041446 Css NA 0.231 mg/L PBTK NA 50% Human Human +DTXSID4041446 Css NA 1.613 mg/L PBTK NA 95% Human Human +DTXSID4041446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041446 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041446 Vd NA 1.45 L/kg 1compartment NA NA Rat Human DTXSID4041446 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041446 TK.Half.Life NA 3.04 hours 1compartment NA NA Rat Human -DTXSID4041446 Css NA 0.2668 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041446 Css NA 1.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041446 Css NA 0.181 mg/L PBTK NA 50% Rat Human -DTXSID4041446 Css NA 0.7368 mg/L PBTK NA 95% Rat Human -DTXSID4041490 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041490 Fup NA 0.9007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041490 Vd NA 1.343 L/kg 1compartment NA NA Human Human -DTXSID4041490 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4041490 TK.Half.Life NA 10.41 hours 1compartment NA NA Human Human -DTXSID4041490 Css NA 0.8194 mg/L 3compartmentss NA 50% Human Human -DTXSID4041490 Css NA 3.341 mg/L 3compartmentss NA 95% Human Human -DTXSID4041490 Css NA 0.7601 mg/L PBTK NA 50% Human Human -DTXSID4041490 Css NA 2.441 mg/L PBTK NA 95% Human Human -DTXSID4041490 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041490 Fup NA 0.9007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041490 Vd NA 1.247 L/kg 1compartment NA NA Rat Human +DTXSID4041446 TK.Half.Life NA 2.069 hours 1compartment NA NA Rat Human +DTXSID4041446 Css NA 0.04429 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041446 Css NA 0.2478 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041446 Css NA 0.02939 mg/L PBTK NA 50% Rat Human +DTXSID4041446 Css NA 0.1575 mg/L PBTK NA 95% Rat Human +DTXSID4041448 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041448 Fup 0.706 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041448 Vd NA 1.218 L/kg 1compartment NA NA Human Human +DTXSID4041448 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4041448 TK.Half.Life NA 11.25 hours 1compartment NA NA Human Human +DTXSID4041448 Css NA 0.9722 mg/L 3compartmentss NA 50% Human Human +DTXSID4041448 Css NA 6.814 mg/L 3compartmentss NA 95% Human Human +DTXSID4041448 Css NA 0.8618 mg/L PBTK NA 50% Human Human +DTXSID4041448 Css NA 4.446 mg/L PBTK NA 95% Human Human +DTXSID4041448 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041448 Fup 0.706 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041448 Vd NA 1.221 L/kg 1compartment NA NA Rat Human +DTXSID4041448 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4041448 TK.Half.Life NA 3.821 hours 1compartment NA NA Rat Human +DTXSID4041448 Css NA 0.05758 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041448 Css NA 0.386 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041448 Css NA 0.05132 mg/L PBTK NA 50% Rat Human +DTXSID4041448 Css NA 0.2429 mg/L PBTK NA 95% Rat Human +DTXSID4041490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041490 Fup 0.599 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041490 Vd NA 1.246 L/kg 1compartment NA NA Human Human +DTXSID4041490 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4041490 TK.Half.Life NA 1.11 hours 1compartment NA NA Human Human +DTXSID4041490 Css NA 0.02562 mg/L 3compartmentss NA 50% Human Human +DTXSID4041490 Css NA 0.3138 mg/L 3compartmentss NA 95% Human Human +DTXSID4041490 Css NA 0.02167 mg/L PBTK NA 50% Human Human +DTXSID4041490 Css NA 0.2209 mg/L PBTK NA 95% Human Human +DTXSID4041490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041490 Fup 0.599 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041490 Vd NA 1.112 L/kg 1compartment NA NA Rat Human DTXSID4041490 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041490 TK.Half.Life NA 3.11 hours 1compartment NA NA Rat Human -DTXSID4041490 Css NA 0.2096 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041490 Css NA 0.7979 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041490 Css NA 0.1916 mg/L PBTK NA 50% Rat Human -DTXSID4041490 Css NA 0.5372 mg/L PBTK NA 95% Rat Human -DTXSID4041494 Clint NA 11.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041494 Fup NA 0.0074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041494 Vd NA 2.738 L/kg 1compartment NA NA Human Human -DTXSID4041494 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID4041494 TK.Half.Life NA 115.2 hours 1compartment NA NA Human Human -DTXSID4041494 Css NA 6.01 mg/L 3compartmentss NA 50% Human Human -DTXSID4041494 Css NA 39.08 mg/L 3compartmentss NA 95% Human Human -DTXSID4041494 Css NA 4.03 mg/L PBTK NA 50% Human Human -DTXSID4041494 Css NA 25.51 mg/L PBTK NA 95% Human Human -DTXSID4041494 Clint NA 11.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041494 Fup NA 0.0074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041494 Vd NA 2.043 L/kg 1compartment NA NA Rat Human -DTXSID4041494 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID4041494 TK.Half.Life NA 23.15 hours 1compartment NA NA Rat Human -DTXSID4041494 Css NA 3.336 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041494 Css NA 18.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041494 Css NA 2.119 mg/L PBTK NA 50% Rat Human -DTXSID4041494 Css NA 11.5 mg/L PBTK NA 95% Rat Human -DTXSID4041521 Clint NA 1.859 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041521 Fup NA 0.8093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041521 Vd NA 2.601 L/kg 1compartment NA NA Human Human -DTXSID4041521 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041521 TK.Half.Life NA 5.728 hours 1compartment NA NA Human Human -DTXSID4041521 Css NA 0.1858 mg/L 3compartmentss NA 50% Human Human -DTXSID4041521 Css NA 1.54 mg/L 3compartmentss NA 95% Human Human -DTXSID4041521 Css NA 0.2053 mg/L PBTK NA 50% Human Human -DTXSID4041521 Css NA 1.154 mg/L PBTK NA 95% Human Human -DTXSID4041521 Clint NA 1.859 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041521 Fup NA 0.8093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041521 Vd NA 2.639 L/kg 1compartment NA NA Rat Human +DTXSID4041490 TK.Half.Life NA 0.4834 hours 1compartment NA NA Rat Human +DTXSID4041490 Css NA 0.0009408 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041490 Css NA 0.01268 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041490 Css NA 0.0007968 mg/L PBTK NA 50% Rat Human +DTXSID4041490 Css NA 0.008871 mg/L PBTK NA 95% Rat Human +DTXSID4041494 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041494 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041494 Vd NA 2.967 L/kg 1compartment NA NA Human Human +DTXSID4041494 Days.Css NA 38 Days PBTK NA NA Human Human +DTXSID4041494 TK.Half.Life NA 193.1 hours 1compartment NA NA Human Human +DTXSID4041494 Css NA 8.322 mg/L 3compartmentss NA 50% Human Human +DTXSID4041494 Css NA 54.91 mg/L 3compartmentss NA 95% Human Human +DTXSID4041494 Css NA 5.712 mg/L PBTK NA 50% Human Human +DTXSID4041494 Css NA 36.56 mg/L PBTK NA 95% Human Human +DTXSID4041494 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041494 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041494 Vd NA 2.222 L/kg 1compartment NA NA Rat Human +DTXSID4041494 Days.Css NA 21 Days PBTK NA NA Rat Human +DTXSID4041494 TK.Half.Life NA 30.56 hours 1compartment NA NA Rat Human +DTXSID4041494 Css NA 1.08 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041494 Css NA 5.732 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041494 Css NA 0.7302 mg/L PBTK NA 50% Rat Human +DTXSID4041494 Css NA 3.71 mg/L PBTK NA 95% Rat Human +DTXSID4041521 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041521 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041521 Vd NA 1.474 L/kg 1compartment NA NA Human Human +DTXSID4041521 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4041521 TK.Half.Life NA 14.13 hours 1compartment NA NA Human Human +DTXSID4041521 Css NA 0.9367 mg/L 3compartmentss NA 50% Human Human +DTXSID4041521 Css NA 6.823 mg/L 3compartmentss NA 95% Human Human +DTXSID4041521 Css NA 0.881 mg/L PBTK NA 50% Human Human +DTXSID4041521 Css NA 4.508 mg/L PBTK NA 95% Human Human +DTXSID4041521 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041521 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041521 Vd NA 1.5 L/kg 1compartment NA NA Rat Human DTXSID4041521 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041521 TK.Half.Life NA 3.056 hours 1compartment NA NA Rat Human -DTXSID4041521 Css NA 0.07664 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041521 Css NA 0.566 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041521 Css NA 0.08448 mg/L PBTK NA 50% Rat Human -DTXSID4041521 Css NA 0.3868 mg/L PBTK NA 95% Rat Human -DTXSID4041527 Clint NA 2.473 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041527 Fup NA 0.696 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041527 Vd NA 2.07 L/kg 1compartment NA NA Human Human -DTXSID4041527 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041527 TK.Half.Life NA 4.463 hours 1compartment NA NA Human Human -DTXSID4041527 Css NA 0.183 mg/L 3compartmentss NA 50% Human Human -DTXSID4041527 Css NA 1.543 mg/L 3compartmentss NA 95% Human Human -DTXSID4041527 Css NA 0.1844 mg/L PBTK NA 50% Human Human -DTXSID4041527 Css NA 1.114 mg/L PBTK NA 95% Human Human -DTXSID4041527 Clint NA 2.473 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041527 Fup NA 0.696 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041527 Vd NA 2.088 L/kg 1compartment NA NA Rat Human +DTXSID4041521 TK.Half.Life NA 4.899 hours 1compartment NA NA Rat Human +DTXSID4041521 Css NA 0.05594 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041521 Css NA 0.3943 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041521 Css NA 0.0528 mg/L PBTK NA 50% Rat Human +DTXSID4041521 Css NA 0.252 mg/L PBTK NA 95% Rat Human +DTXSID4041527 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041527 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041527 Vd NA 2.218 L/kg 1compartment NA NA Human Human +DTXSID4041527 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4041527 TK.Half.Life NA 23.43 hours 1compartment NA NA Human Human +DTXSID4041527 Css NA 0.9232 mg/L 3compartmentss NA 50% Human Human +DTXSID4041527 Css NA 7.207 mg/L 3compartmentss NA 95% Human Human +DTXSID4041527 Css NA 0.9398 mg/L PBTK NA 50% Human Human +DTXSID4041527 Css NA 4.964 mg/L PBTK NA 95% Human Human +DTXSID4041527 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041527 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041527 Vd NA 2.226 L/kg 1compartment NA NA Rat Human DTXSID4041527 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041527 TK.Half.Life NA 2.409 hours 1compartment NA NA Rat Human -DTXSID4041527 Css NA 0.07803 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041527 Css NA 0.6198 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041527 Css NA 0.07803 mg/L PBTK NA 50% Rat Human -DTXSID4041527 Css NA 0.4005 mg/L PBTK NA 95% Rat Human -DTXSID4041529 Clint NA 6.633 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041529 Fup NA 0.6358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041529 Vd NA 0.7094 L/kg 1compartment NA NA Human Human +DTXSID4041527 TK.Half.Life NA 7.872 hours 1compartment NA NA Rat Human +DTXSID4041527 Css NA 0.0549 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041527 Css NA 0.4107 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041527 Css NA 0.05713 mg/L PBTK NA 50% Rat Human +DTXSID4041527 Css NA 0.2713 mg/L PBTK NA 95% Rat Human +DTXSID4041529 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041529 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041529 Vd NA 0.5563 L/kg 1compartment NA NA Human Human DTXSID4041529 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041529 TK.Half.Life NA 0.9889 hours 1compartment NA NA Human Human -DTXSID4041529 Css NA 0.1032 mg/L 3compartmentss NA 50% Human Human -DTXSID4041529 Css NA 1.012 mg/L 3compartmentss NA 95% Human Human -DTXSID4041529 Css NA 0.08264 mg/L PBTK NA 50% Human Human -DTXSID4041529 Css NA 0.6613 mg/L PBTK NA 95% Human Human -DTXSID4041529 Clint NA 6.633 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041529 Fup NA 0.6358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041529 Vd NA 0.7185 L/kg 1compartment NA NA Rat Human +DTXSID4041529 TK.Half.Life NA 8.675 hours 1compartment NA NA Human Human +DTXSID4041529 Css NA 1.714 mg/L 3compartmentss NA 50% Human Human +DTXSID4041529 Css NA 7.489 mg/L 3compartmentss NA 95% Human Human +DTXSID4041529 Css NA 1.262 mg/L PBTK NA 50% Human Human +DTXSID4041529 Css NA 4.708 mg/L PBTK NA 95% Human Human +DTXSID4041529 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041529 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041529 Vd NA 0.5617 L/kg 1compartment NA NA Rat Human DTXSID4041529 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041529 TK.Half.Life NA 0.5365 hours 1compartment NA NA Rat Human -DTXSID4041529 Css NA 0.05064 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041529 Css NA 0.4047 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041529 Css NA 0.03924 mg/L PBTK NA 50% Rat Human -DTXSID4041529 Css NA 0.2453 mg/L PBTK NA 95% Rat Human -DTXSID4041573 Clint NA 68.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041573 Fup NA 0.5651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041573 Vd NA 0.7833 L/kg 1compartment NA NA Human Human -DTXSID4041573 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041573 TK.Half.Life NA 0.5796 hours 1compartment NA NA Human Human -DTXSID4041573 Css NA 0.01212 mg/L 3compartmentss NA 50% Human Human -DTXSID4041573 Css NA 0.1414 mg/L 3compartmentss NA 95% Human Human -DTXSID4041573 Css NA 0.009587 mg/L PBTK NA 50% Human Human -DTXSID4041573 Css NA 0.09469 mg/L PBTK NA 95% Human Human -DTXSID4041573 Clint NA 68.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041573 Fup NA 0.5651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041573 Vd NA 0.7663 L/kg 1compartment NA NA Rat Human +DTXSID4041529 TK.Half.Life NA 2.979 hours 1compartment NA NA Rat Human +DTXSID4041529 Css NA 0.1086 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041529 Css NA 0.3986 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041529 Css NA 0.07921 mg/L PBTK NA 50% Rat Human +DTXSID4041529 Css NA 0.245 mg/L PBTK NA 95% Rat Human +DTXSID4041573 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041573 Fup 0.554 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041573 Vd NA 1.036 L/kg 1compartment NA NA Human Human +DTXSID4041573 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4041573 TK.Half.Life NA 12.76 hours 1compartment NA NA Human Human +DTXSID4041573 Css NA 1.267 mg/L 3compartmentss NA 50% Human Human +DTXSID4041573 Css NA 8.637 mg/L 3compartmentss NA 95% Human Human +DTXSID4041573 Css NA 1.054 mg/L PBTK NA 50% Human Human +DTXSID4041573 Css NA 5.54 mg/L PBTK NA 95% Human Human +DTXSID4041573 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041573 Fup 0.554 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041573 Vd NA 0.9514 L/kg 1compartment NA NA Rat Human DTXSID4041573 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041573 TK.Half.Life NA 0.2609 hours 1compartment NA NA Rat Human -DTXSID4041573 Css NA 0.006353 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041573 Css NA 0.06553 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041573 Css NA 0.004928 mg/L PBTK NA 50% Rat Human -DTXSID4041573 Css NA 0.04251 mg/L PBTK NA 95% Rat Human +DTXSID4041573 TK.Half.Life NA 3.836 hours 1compartment NA NA Rat Human +DTXSID4041573 Css NA 0.07797 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041573 Css NA 0.4946 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041573 Css NA 0.06479 mg/L PBTK NA 50% Rat Human +DTXSID4041573 Css NA 0.3045 mg/L PBTK NA 95% Rat Human DTXSID4041575 Clint NA 0.5915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4041575 Fup NA 0.6477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041575 Vd NA 0.6159 L/kg 1compartment NA NA Human Human +DTXSID4041575 Vd NA 0.6297 L/kg 1compartment NA NA Human Human DTXSID4041575 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041575 TK.Half.Life NA 2.975 hours 1compartment NA NA Human Human -DTXSID4041575 Css NA 0.5454 mg/L 3compartmentss NA 50% Human Human -DTXSID4041575 Css NA 3.868 mg/L 3compartmentss NA 95% Human Human -DTXSID4041575 Css NA 0.4307 mg/L PBTK NA 50% Human Human -DTXSID4041575 Css NA 2.445 mg/L PBTK NA 95% Human Human +DTXSID4041575 TK.Half.Life NA 3.086 hours 1compartment NA NA Human Human +DTXSID4041575 Css NA 0.461 mg/L 3compartmentss NA 50% Human Human +DTXSID4041575 Css NA 3.296 mg/L 3compartmentss NA 95% Human Human +DTXSID4041575 Css NA 0.3667 mg/L PBTK NA 50% Human Human +DTXSID4041575 Css NA 2.079 mg/L PBTK NA 95% Human Human DTXSID4041575 Clint NA 0.5915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4041575 Fup NA 0.6477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041575 Vd NA 0.644 L/kg 1compartment NA NA Rat Human +DTXSID4041575 Vd NA 0.6558 L/kg 1compartment NA NA Rat Human DTXSID4041575 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041575 TK.Half.Life NA 1.43 hours 1compartment NA NA Rat Human -DTXSID4041575 Css NA 0.1959 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041575 Css NA 1.272 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041575 Css NA 0.1497 mg/L PBTK NA 50% Rat Human -DTXSID4041575 Css NA 0.7418 mg/L PBTK NA 95% Rat Human -DTXSID4041600 Clint NA 144.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041600 Fup NA 0.045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041600 Vd NA 1.628 L/kg 1compartment NA NA Human Human +DTXSID4041575 TK.Half.Life NA 1.471 hours 1compartment NA NA Rat Human +DTXSID4041575 Css NA 0.01207 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041575 Css NA 0.1027 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041575 Css NA 0.009302 mg/L PBTK NA 50% Rat Human +DTXSID4041575 Css NA 0.06509 mg/L PBTK NA 95% Rat Human +DTXSID4041600 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041600 Fup 0.082 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041600 Vd NA 2.094 L/kg 1compartment NA NA Human Human DTXSID4041600 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041600 TK.Half.Life NA 2.43 hours 1compartment NA NA Human Human -DTXSID4041600 Css NA 0.1056 mg/L 3compartmentss NA 50% Human Human -DTXSID4041600 Css NA 0.838 mg/L 3compartmentss NA 95% Human Human -DTXSID4041600 Css NA 0.0692 mg/L PBTK NA 50% Human Human -DTXSID4041600 Css NA 0.5186 mg/L PBTK NA 95% Human Human -DTXSID4041600 Clint NA 144.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041600 Fup NA 0.045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041600 Vd NA 1.278 L/kg 1compartment NA NA Rat Human +DTXSID4041600 TK.Half.Life NA 7.54 hours 1compartment NA NA Human Human +DTXSID4041600 Css NA 0.4053 mg/L 3compartmentss NA 50% Human Human +DTXSID4041600 Css NA 2.978 mg/L 3compartmentss NA 95% Human Human +DTXSID4041600 Css NA 0.2784 mg/L PBTK NA 50% Human Human +DTXSID4041600 Css NA 1.941 mg/L PBTK NA 95% Human Human +DTXSID4041600 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041600 Fup 0.082 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041600 Vd NA 1.656 L/kg 1compartment NA NA Rat Human DTXSID4041600 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041600 TK.Half.Life NA 0.9236 hours 1compartment NA NA Rat Human -DTXSID4041600 Css NA 0.06081 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041600 Css NA 0.3853 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041600 Css NA 0.03734 mg/L PBTK NA 50% Rat Human -DTXSID4041600 Css NA 0.2296 mg/L PBTK NA 95% Rat Human -DTXSID4041654 Clint NA 22.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041654 Fup NA 0.0213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041654 Vd NA 2.672 L/kg 1compartment NA NA Human Human -DTXSID4041654 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4041654 TK.Half.Life NA 35.31 hours 1compartment NA NA Human Human -DTXSID4041654 Css NA 1.811 mg/L 3compartmentss NA 50% Human Human -DTXSID4041654 Css NA 12.71 mg/L 3compartmentss NA 95% Human Human -DTXSID4041654 Css NA 1.213 mg/L PBTK NA 50% Human Human -DTXSID4041654 Css NA 8.246 mg/L PBTK NA 95% Human Human -DTXSID4041654 Clint NA 22.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041654 Fup NA 0.0213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041654 Vd NA 1.996 L/kg 1compartment NA NA Rat Human -DTXSID4041654 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4041654 TK.Half.Life NA 7.729 hours 1compartment NA NA Rat Human -DTXSID4041654 Css NA 1.027 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041654 Css NA 5.641 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041654 Css NA 0.6524 mg/L PBTK NA 50% Rat Human -DTXSID4041654 Css NA 3.463 mg/L PBTK NA 95% Rat Human +DTXSID4041600 TK.Half.Life NA 2.731 hours 1compartment NA NA Rat Human +DTXSID4041600 Css NA 0.05228 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041600 Css NA 0.2992 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041600 Css NA 0.03566 mg/L PBTK NA 50% Rat Human +DTXSID4041600 Css NA 0.1897 mg/L PBTK NA 95% Rat Human +DTXSID4041654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041654 Fup 0.0219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041654 Vd NA 4.261 L/kg 1compartment NA NA Human Human +DTXSID4041654 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID4041654 TK.Half.Life NA 128.1 hours 1compartment NA NA Human Human +DTXSID4041654 Css NA 3.102 mg/L 3compartmentss NA 50% Human Human +DTXSID4041654 Css NA 18.01 mg/L 3compartmentss NA 95% Human Human +DTXSID4041654 Css NA 2.358 mg/L PBTK NA 50% Human Human +DTXSID4041654 Css NA 13.63 mg/L PBTK NA 95% Human Human +DTXSID4041654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041654 Fup 0.0219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041654 Vd NA 3.231 L/kg 1compartment NA NA Rat Human +DTXSID4041654 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID4041654 TK.Half.Life NA 17.21 hours 1compartment NA NA Rat Human +DTXSID4041654 Css NA 0.4019 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041654 Css NA 1.93 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041654 Css NA 0.3056 mg/L PBTK NA 50% Rat Human +DTXSID4041654 Css NA 1.482 mg/L PBTK NA 95% Rat Human DTXSID4041656 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4041656 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4041656 Vd NA 0.3131 L/kg 1compartment NA NA Human Human DTXSID4041656 Days.Css NA 9 Days PBTK NA NA Human Human DTXSID4041656 TK.Half.Life NA 52.23 hours 1compartment NA NA Human Human -DTXSID4041656 Css NA 28.28 mg/L 3compartmentss NA 50% Human Human -DTXSID4041656 Css NA 163 mg/L 3compartmentss NA 95% Human Human -DTXSID4041656 Css NA 17.26 mg/L PBTK NA 50% Human Human -DTXSID4041656 Css NA 94.01 mg/L PBTK NA 95% Human Human +DTXSID4041656 Css NA 27.78 mg/L 3compartmentss NA 50% Human Human +DTXSID4041656 Css NA 158.8 mg/L 3compartmentss NA 95% Human Human +DTXSID4041656 Css NA 16.94 mg/L PBTK NA 50% Human Human +DTXSID4041656 Css NA 93.1 mg/L PBTK NA 95% Human Human DTXSID4041656 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4041656 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4041656 Vd NA 0.3054 L/kg 1compartment NA NA Rat Human DTXSID4041656 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID4041656 TK.Half.Life NA 17.35 hours 1compartment NA NA Rat Human -DTXSID4041656 Css NA 8.027 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041656 Css NA 40.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041656 Css NA 4.584 mg/L PBTK NA 50% Rat Human -DTXSID4041656 Css NA 21.94 mg/L PBTK NA 95% Rat Human -DTXSID4041783 Clint NA 10.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041783 Fup NA 0.1946 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041783 Vd NA 0.9499 L/kg 1compartment NA NA Human Human +DTXSID4041656 Css NA 1.79 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041656 Css NA 8.778 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041656 Css NA 1.059 mg/L PBTK NA 50% Rat Human +DTXSID4041656 Css NA 4.971 mg/L PBTK NA 95% Rat Human +DTXSID4041783 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041783 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041783 Vd NA 0.7884 L/kg 1compartment NA NA Human Human DTXSID4041783 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041783 TK.Half.Life NA 2.535 hours 1compartment NA NA Human Human -DTXSID4041783 Css NA 0.2417 mg/L 3compartmentss NA 50% Human Human -DTXSID4041783 Css NA 1.544 mg/L 3compartmentss NA 95% Human Human -DTXSID4041783 Css NA 0.168 mg/L PBTK NA 50% Human Human -DTXSID4041783 Css NA 1.018 mg/L PBTK NA 95% Human Human -DTXSID4041783 Clint NA 10.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041783 Fup NA 0.1946 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041783 Vd NA 0.7888 L/kg 1compartment NA NA Rat Human +DTXSID4041783 TK.Half.Life NA 3.107 hours 1compartment NA NA Human Human +DTXSID4041783 Css NA 0.4024 mg/L 3compartmentss NA 50% Human Human +DTXSID4041783 Css NA 2.333 mg/L 3compartmentss NA 95% Human Human +DTXSID4041783 Css NA 0.2748 mg/L PBTK NA 50% Human Human +DTXSID4041783 Css NA 1.524 mg/L PBTK NA 95% Human Human +DTXSID4041783 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041783 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041783 Vd NA 0.6687 L/kg 1compartment NA NA Rat Human DTXSID4041783 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041783 TK.Half.Life NA 1.175 hours 1compartment NA NA Rat Human -DTXSID4041783 Css NA 0.1298 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041783 Css NA 0.5897 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041783 Css NA 0.08644 mg/L PBTK NA 50% Rat Human -DTXSID4041783 Css NA 0.3659 mg/L PBTK NA 95% Rat Human -DTXSID4041812 Clint NA 2.104 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041812 Fup NA 0.2136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041812 Vd NA 2.601 L/kg 1compartment NA NA Human Human -DTXSID4041812 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID4041812 TK.Half.Life NA 47.87 hours 1compartment NA NA Human Human -DTXSID4041812 Css NA 2.108 mg/L 3compartmentss NA 50% Human Human -DTXSID4041812 Css NA 8.723 mg/L 3compartmentss NA 95% Human Human -DTXSID4041812 Css NA 1.528 mg/L PBTK NA 50% Human Human -DTXSID4041812 Css NA 5.924 mg/L PBTK NA 95% Human Human -DTXSID4041812 Clint NA 2.104 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041812 Fup NA 0.2136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041812 Vd NA 1.979 L/kg 1compartment NA NA Rat Human -DTXSID4041812 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4041812 TK.Half.Life NA 10.06 hours 1compartment NA NA Rat Human -DTXSID4041812 Css NA 0.9922 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041812 Css NA 2.901 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041812 Css NA 0.6937 mg/L PBTK NA 50% Rat Human -DTXSID4041812 Css NA 1.861 mg/L PBTK NA 95% Rat Human -DTXSID4041995 Clint NA 2.945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041995 Fup NA 0.1065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041995 Vd NA 1.478 L/kg 1compartment NA NA Human Human -DTXSID4041995 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4041995 TK.Half.Life NA 19.06 hours 1compartment NA NA Human Human -DTXSID4041995 Css NA 1.862 mg/L 3compartmentss NA 50% Human Human -DTXSID4041995 Css NA 10.13 mg/L 3compartmentss NA 95% Human Human -DTXSID4041995 Css NA 1.243 mg/L PBTK NA 50% Human Human -DTXSID4041995 Css NA 6.303 mg/L PBTK NA 95% Human Human -DTXSID4041995 Clint NA 2.945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041995 Fup NA 0.1065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041995 Vd NA 1.135 L/kg 1compartment NA NA Rat Human +DTXSID4041783 TK.Half.Life NA 1.51 hours 1compartment NA NA Rat Human +DTXSID4041783 Css NA 0.04792 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041783 Css NA 0.2075 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041783 Css NA 0.03224 mg/L PBTK NA 50% Rat Human +DTXSID4041783 Css NA 0.129 mg/L PBTK NA 95% Rat Human +DTXSID4041991 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041991 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041991 Vd NA 1.036 L/kg 1compartment NA NA Human Human +DTXSID4041991 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4041991 TK.Half.Life NA 19.3 hours 1compartment NA NA Human Human +DTXSID4041991 Css NA 1.92 mg/L 3compartmentss NA 50% Human Human +DTXSID4041991 Css NA 8.211 mg/L 3compartmentss NA 95% Human Human +DTXSID4041991 Css NA 1.488 mg/L PBTK NA 50% Human Human +DTXSID4041991 Css NA 5.357 mg/L PBTK NA 95% Human Human +DTXSID4041991 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041991 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041991 Vd NA 0.9061 L/kg 1compartment NA NA Rat Human +DTXSID4041991 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4041991 TK.Half.Life NA 5.419 hours 1compartment NA NA Rat Human +DTXSID4041991 Css NA 0.1214 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041991 Css NA 0.4423 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041991 Css NA 0.0937 mg/L PBTK NA 50% Rat Human +DTXSID4041991 Css NA 0.279 mg/L PBTK NA 95% Rat Human +DTXSID4041995 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041995 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041995 Vd NA 1.489 L/kg 1compartment NA NA Human Human +DTXSID4041995 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4041995 TK.Half.Life NA 4.004 hours 1compartment NA NA Human Human +DTXSID4041995 Css NA 0.284 mg/L 3compartmentss NA 50% Human Human +DTXSID4041995 Css NA 2.073 mg/L 3compartmentss NA 95% Human Human +DTXSID4041995 Css NA 0.1882 mg/L PBTK NA 50% Human Human +DTXSID4041995 Css NA 1.306 mg/L PBTK NA 95% Human Human +DTXSID4041995 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041995 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041995 Vd NA 1.143 L/kg 1compartment NA NA Rat Human DTXSID4041995 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041995 TK.Half.Life NA 6.975 hours 1compartment NA NA Rat Human -DTXSID4041995 Css NA 0.9032 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041995 Css NA 3.831 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041995 Css NA 0.5719 mg/L PBTK NA 50% Rat Human -DTXSID4041995 Css NA 2.196 mg/L PBTK NA 95% Rat Human -DTXSID4041997 Clint NA 18.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041997 Fup NA 0.5187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4041997 Vd NA 0.9449 L/kg 1compartment NA NA Human Human +DTXSID4041995 TK.Half.Life NA 1.558 hours 1compartment NA NA Rat Human +DTXSID4041995 Css NA 0.03628 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041995 Css NA 0.2178 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041995 Css NA 0.02368 mg/L PBTK NA 50% Rat Human +DTXSID4041995 Css NA 0.1354 mg/L PBTK NA 95% Rat Human +DTXSID4041997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041997 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4041997 Vd NA 0.8636 L/kg 1compartment NA NA Human Human DTXSID4041997 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4041997 TK.Half.Life NA 0.9551 hours 1compartment NA NA Human Human -DTXSID4041997 Css NA 0.04572 mg/L 3compartmentss NA 50% Human Human -DTXSID4041997 Css NA 0.4124 mg/L 3compartmentss NA 95% Human Human -DTXSID4041997 Css NA 0.03674 mg/L PBTK NA 50% Human Human -DTXSID4041997 Css NA 0.2851 mg/L PBTK NA 95% Human Human -DTXSID4041997 Clint NA 18.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041997 Fup NA 0.5187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4041997 Vd NA 0.9521 L/kg 1compartment NA NA Rat Human +DTXSID4041997 TK.Half.Life NA 0.8963 hours 1compartment NA NA Human Human +DTXSID4041997 Css NA 0.04203 mg/L 3compartmentss NA 50% Human Human +DTXSID4041997 Css NA 0.3513 mg/L 3compartmentss NA 95% Human Human +DTXSID4041997 Css NA 0.03265 mg/L PBTK NA 50% Human Human +DTXSID4041997 Css NA 0.2442 mg/L PBTK NA 95% Human Human +DTXSID4041997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041997 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4041997 Vd NA 0.8692 L/kg 1compartment NA NA Rat Human DTXSID4041997 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4041997 TK.Half.Life NA 0.494 hours 1compartment NA NA Rat Human -DTXSID4041997 Css NA 0.02404 mg/L 3compartmentss NA 50% Rat Human -DTXSID4041997 Css NA 0.1828 mg/L 3compartmentss NA 95% Rat Human -DTXSID4041997 Css NA 0.01889 mg/L PBTK NA 50% Rat Human -DTXSID4041997 Css NA 0.1175 mg/L PBTK NA 95% Rat Human -DTXSID4042090 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042090 Fup NA 0.1871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042090 Vd NA 3.175 L/kg 1compartment NA NA Human Human -DTXSID4042090 Days.Css NA 51 Days PBTK NA NA Human Human -DTXSID4042090 TK.Half.Life NA 246.8 hours 1compartment NA NA Human Human -DTXSID4042090 Css NA 9.308 mg/L 3compartmentss NA 50% Human Human -DTXSID4042090 Css NA 51.63 mg/L 3compartmentss NA 95% Human Human -DTXSID4042090 Css NA 6.597 mg/L PBTK NA 50% Human Human -DTXSID4042090 Css NA 35.43 mg/L PBTK NA 95% Human Human -DTXSID4042090 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042090 Fup NA 0.1871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042090 Vd NA 2.401 L/kg 1compartment NA NA Rat Human -DTXSID4042090 Days.Css NA 28 Days PBTK NA NA Rat Human -DTXSID4042090 TK.Half.Life NA 32.02 hours 1compartment NA NA Rat Human -DTXSID4042090 Css NA 5.078 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042090 Css NA 22.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042090 Css NA 3.435 mg/L PBTK NA 50% Rat Human -DTXSID4042090 Css NA 14.6 mg/L PBTK NA 95% Rat Human -DTXSID4042094 Clint NA 22.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042094 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042094 Vd NA 3.035 L/kg 1compartment NA NA Human Human -DTXSID4042094 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID4042094 TK.Half.Life NA 48.37 hours 1compartment NA NA Human Human -DTXSID4042094 Css NA 1.936 mg/L 3compartmentss NA 50% Human Human -DTXSID4042094 Css NA 12.27 mg/L 3compartmentss NA 95% Human Human -DTXSID4042094 Css NA 1.342 mg/L PBTK NA 50% Human Human -DTXSID4042094 Css NA 8.19 mg/L PBTK NA 95% Human Human -DTXSID4042094 Clint NA 22.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042094 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042094 Vd NA 2.275 L/kg 1compartment NA NA Rat Human -DTXSID4042094 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4042094 TK.Half.Life NA 7.509 hours 1compartment NA NA Rat Human -DTXSID4042094 Css NA 1.081 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042094 Css NA 5.578 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042094 Css NA 0.7158 mg/L PBTK NA 50% Rat Human -DTXSID4042094 Css NA 3.585 mg/L PBTK NA 95% Rat Human +DTXSID4041997 TK.Half.Life NA 0.4621 hours 1compartment NA NA Rat Human +DTXSID4041997 Css NA 0.005171 mg/L 3compartmentss NA 50% Rat Human +DTXSID4041997 Css NA 0.03453 mg/L 3compartmentss NA 95% Rat Human +DTXSID4041997 Css NA 0.00407 mg/L PBTK NA 50% Rat Human +DTXSID4041997 Css NA 0.02333 mg/L PBTK NA 95% Rat Human +DTXSID4042090 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042090 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042090 Vd NA 2.969 L/kg 1compartment NA NA Human Human +DTXSID4042090 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4042090 TK.Half.Life NA 12.49 hours 1compartment NA NA Human Human +DTXSID4042090 Css NA 0.4258 mg/L 3compartmentss NA 50% Human Human +DTXSID4042090 Css NA 2.761 mg/L 3compartmentss NA 95% Human Human +DTXSID4042090 Css NA 0.3156 mg/L PBTK NA 50% Human Human +DTXSID4042090 Css NA 1.976 mg/L PBTK NA 95% Human Human +DTXSID4042090 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042090 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042090 Vd NA 2.35 L/kg 1compartment NA NA Rat Human +DTXSID4042090 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4042090 TK.Half.Life NA 3.162 hours 1compartment NA NA Rat Human +DTXSID4042090 Css NA 0.0546 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042090 Css NA 0.2844 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042090 Css NA 0.04022 mg/L PBTK NA 50% Rat Human +DTXSID4042090 Css NA 0.1976 mg/L PBTK NA 95% Rat Human +DTXSID4042094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042094 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042094 Vd NA 3.085 L/kg 1compartment NA NA Human Human +DTXSID4042094 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID4042094 TK.Half.Life NA 67.76 hours 1compartment NA NA Human Human +DTXSID4042094 Css NA 2.617 mg/L 3compartmentss NA 50% Human Human +DTXSID4042094 Css NA 16.1 mg/L 3compartmentss NA 95% Human Human +DTXSID4042094 Css NA 1.805 mg/L PBTK NA 50% Human Human +DTXSID4042094 Css NA 10.86 mg/L PBTK NA 95% Human Human +DTXSID4042094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042094 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042094 Vd NA 2.311 L/kg 1compartment NA NA Rat Human +DTXSID4042094 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4042094 TK.Half.Life NA 9.703 hours 1compartment NA NA Rat Human +DTXSID4042094 Css NA 0.3391 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042094 Css NA 1.93 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042094 Css NA 0.2319 mg/L PBTK NA 50% Rat Human +DTXSID4042094 Css NA 1.276 mg/L PBTK NA 95% Rat Human DTXSID4042096 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4042096 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042096 Vd NA 0.6978 L/kg 1compartment NA NA Human Human +DTXSID4042096 Vd NA 0.6753 L/kg 1compartment NA NA Human Human DTXSID4042096 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4042096 TK.Half.Life NA 4.516 hours 1compartment NA NA Human Human -DTXSID4042096 Css NA 0.8472 mg/L 3compartmentss NA 50% Human Human -DTXSID4042096 Css NA 5.575 mg/L 3compartmentss NA 95% Human Human -DTXSID4042096 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID4042096 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID4042096 TK.Half.Life NA 4.37 hours 1compartment NA NA Human Human +DTXSID4042096 Css NA 0.7226 mg/L 3compartmentss NA 50% Human Human +DTXSID4042096 Css NA 5.093 mg/L 3compartmentss NA 95% Human Human +DTXSID4042096 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID4042096 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID4042096 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4042096 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042096 Vd NA 0.7483 L/kg 1compartment NA NA Rat Human +DTXSID4042096 Vd NA 0.7232 L/kg 1compartment NA NA Rat Human DTXSID4042096 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4042096 TK.Half.Life NA 1.65 hours 1compartment NA NA Rat Human -DTXSID4042096 Css NA 0.2128 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042096 Css NA 1.339 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042096 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID4042096 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID4042096 TK.Half.Life NA 1.595 hours 1compartment NA NA Rat Human +DTXSID4042096 Css NA 0.01328 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042096 Css NA 0.1009 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042096 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID4042096 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID4042121 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4042121 Fup 0.03419 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID4042121 Vd NA 1.568 L/kg 1compartment NA NA Human Human DTXSID4042121 Days.Css NA 105 Days PBTK NA NA Human Human DTXSID4042121 TK.Half.Life NA 437.6 hours 1compartment NA NA Human Human -DTXSID4042121 Css NA 43.73 mg/L 3compartmentss NA 50% Human Human -DTXSID4042121 Css NA 172.1 mg/L 3compartmentss NA 95% Human Human -DTXSID4042121 Css NA 27.67 mg/L PBTK NA 50% Human Human -DTXSID4042121 Css NA 102.7 mg/L PBTK NA 95% Human Human +DTXSID4042121 Css NA 42.46 mg/L 3compartmentss NA 50% Human Human +DTXSID4042121 Css NA 167.8 mg/L 3compartmentss NA 95% Human Human +DTXSID4042121 Css NA 26.81 mg/L PBTK NA 50% Human Human +DTXSID4042121 Css NA 100.9 mg/L PBTK NA 95% Human Human DTXSID4042121 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4042121 Fup 0.03419 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID4042121 Vd NA 1.171 L/kg 1compartment NA NA Rat Human DTXSID4042121 Days.Css NA 24 Days PBTK NA NA Rat Human DTXSID4042121 TK.Half.Life NA 84.07 hours 1compartment NA NA Rat Human -DTXSID4042121 Css NA 12.21 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042121 Css NA 40.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042121 Css NA 7.262 mg/L PBTK NA 50% Rat Human -DTXSID4042121 Css NA 22.64 mg/L PBTK NA 95% Rat Human +DTXSID4042121 Css NA 2.808 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042121 Css NA 8.976 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042121 Css NA 1.728 mg/L PBTK NA 50% Rat Human +DTXSID4042121 Css NA 5.188 mg/L PBTK NA 95% Rat Human DTXSID4042123 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4042123 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042123 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID4042123 Vd NA 0.3574 L/kg 1compartment NA NA Human Human DTXSID4042123 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4042123 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID4042123 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID4042123 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID4042123 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID4042123 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID4042123 TK.Half.Life NA 7.158 hours 1compartment NA NA Human Human +DTXSID4042123 Css NA 2.029 mg/L 3compartmentss NA 50% Human Human +DTXSID4042123 Css NA 8.56 mg/L 3compartmentss NA 95% Human Human +DTXSID4042123 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID4042123 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID4042123 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4042123 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042123 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID4042123 Vd NA 0.3706 L/kg 1compartment NA NA Rat Human DTXSID4042123 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4042123 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID4042123 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042123 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042123 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID4042123 Css NA 1.313 mg/L PBTK NA 95% Rat Human -DTXSID4042129 Clint NA 12.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042129 Fup NA 0.0732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042129 Vd NA 2.978 L/kg 1compartment NA NA Human Human -DTXSID4042129 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID4042129 TK.Half.Life NA 56.08 hours 1compartment NA NA Human Human -DTXSID4042129 Css NA 2.347 mg/L 3compartmentss NA 50% Human Human -DTXSID4042129 Css NA 13.75 mg/L 3compartmentss NA 95% Human Human -DTXSID4042129 Css NA 1.622 mg/L PBTK NA 50% Human Human -DTXSID4042129 Css NA 9.371 mg/L PBTK NA 95% Human Human -DTXSID4042129 Clint NA 12.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042129 Fup NA 0.0732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042129 Vd NA 2.234 L/kg 1compartment NA NA Rat Human -DTXSID4042129 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID4042129 TK.Half.Life NA 9.18 hours 1compartment NA NA Rat Human -DTXSID4042129 Css NA 1.292 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042129 Css NA 6.094 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042129 Css NA 0.8549 mg/L PBTK NA 50% Rat Human -DTXSID4042129 Css NA 3.97 mg/L PBTK NA 95% Rat Human -DTXSID4042171 Clint NA 30.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042171 Fup NA 0.0745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042171 Vd NA 2.983 L/kg 1compartment NA NA Human Human -DTXSID4042171 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4042171 TK.Half.Life NA 12.45 hours 1compartment NA NA Human Human -DTXSID4042171 Css NA 0.4474 mg/L 3compartmentss NA 50% Human Human -DTXSID4042171 Css NA 2.973 mg/L 3compartmentss NA 95% Human Human -DTXSID4042171 Css NA 0.3194 mg/L PBTK NA 50% Human Human -DTXSID4042171 Css NA 2.009 mg/L PBTK NA 95% Human Human -DTXSID4042171 Clint NA 30.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042171 Fup NA 0.0745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042171 Vd NA 2.318 L/kg 1compartment NA NA Rat Human +DTXSID4042123 TK.Half.Life NA 2.528 hours 1compartment NA NA Rat Human +DTXSID4042123 Css NA 0.03806 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042123 Css NA 0.2257 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042123 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID4042123 Css NA 0.1369 mg/L PBTK NA 95% Rat Human +DTXSID4042171 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042171 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042171 Vd NA 3.166 L/kg 1compartment NA NA Human Human +DTXSID4042171 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4042171 TK.Half.Life NA 15.32 hours 1compartment NA NA Human Human +DTXSID4042171 Css NA 0.482 mg/L 3compartmentss NA 50% Human Human +DTXSID4042171 Css NA 3.274 mg/L 3compartmentss NA 95% Human Human +DTXSID4042171 Css NA 0.3548 mg/L PBTK NA 50% Human Human +DTXSID4042171 Css NA 2.285 mg/L PBTK NA 95% Human Human +DTXSID4042171 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042171 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042171 Vd NA 2.472 L/kg 1compartment NA NA Rat Human DTXSID4042171 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4042171 TK.Half.Life NA 2.888 hours 1compartment NA NA Rat Human -DTXSID4042171 Css NA 0.2495 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042171 Css NA 1.303 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042171 Css NA 0.1708 mg/L PBTK NA 50% Rat Human -DTXSID4042171 Css NA 0.8559 mg/L PBTK NA 95% Rat Human -DTXSID4042206 Clint 19.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4042206 Fup 0.0125 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4042206 Vd NA 2.19 L/kg 1compartment NA NA Human Human -DTXSID4042206 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4042206 TK.Half.Life NA 35.13 hours 1compartment NA NA Human Human -DTXSID4042206 Css NA 2.394 mg/L 3compartmentss NA 50% Human Human -DTXSID4042206 Css NA 17.4 mg/L 3compartmentss NA 95% Human Human -DTXSID4042206 Css NA 1.55 mg/L PBTK NA 50% Human Human -DTXSID4042206 Css NA 10.79 mg/L PBTK NA 95% Human Human -DTXSID4042206 Clint 19.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4042206 Fup 0.0125 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4042206 Vd NA 1.634 L/kg 1compartment NA NA Rat Human -DTXSID4042206 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4042206 TK.Half.Life NA 10.44 hours 1compartment NA NA Rat Human -DTXSID4042206 Css NA 1.365 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042206 Css NA 7.605 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042206 Css NA 0.8332 mg/L PBTK NA 50% Rat Human -DTXSID4042206 Css NA 4.538 mg/L PBTK NA 95% Rat Human -DTXSID4042208 Clint NA 16.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042208 Fup NA 0.1186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042208 Vd NA 0.8734 L/kg 1compartment NA NA Human Human +DTXSID4042171 TK.Half.Life NA 3.155 hours 1compartment NA NA Rat Human +DTXSID4042171 Css NA 0.06176 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042171 Css NA 0.3314 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042171 Css NA 0.04556 mg/L PBTK NA 50% Rat Human +DTXSID4042171 Css NA 0.2343 mg/L PBTK NA 95% Rat Human +DTXSID4042208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042208 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042208 Vd NA 1.144 L/kg 1compartment NA NA Human Human DTXSID4042208 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4042208 TK.Half.Life NA 2.399 hours 1compartment NA NA Human Human -DTXSID4042208 Css NA 0.3114 mg/L 3compartmentss NA 50% Human Human -DTXSID4042208 Css NA 2.398 mg/L 3compartmentss NA 95% Human Human -DTXSID4042208 Css NA 0.2034 mg/L PBTK NA 50% Human Human -DTXSID4042208 Css NA 1.486 mg/L PBTK NA 95% Human Human -DTXSID4042208 Clint NA 16.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042208 Fup NA 0.1186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042208 Vd NA 0.7053 L/kg 1compartment NA NA Rat Human +DTXSID4042208 TK.Half.Life NA 2.976 hours 1compartment NA NA Human Human +DTXSID4042208 Css NA 0.2766 mg/L 3compartmentss NA 50% Human Human +DTXSID4042208 Css NA 2.158 mg/L 3compartmentss NA 95% Human Human +DTXSID4042208 Css NA 0.1804 mg/L PBTK NA 50% Human Human +DTXSID4042208 Css NA 1.339 mg/L PBTK NA 95% Human Human +DTXSID4042208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042208 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042208 Vd NA 0.8922 L/kg 1compartment NA NA Rat Human DTXSID4042208 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4042208 TK.Half.Life NA 1.101 hours 1compartment NA NA Rat Human -DTXSID4042208 Css NA 0.1702 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042208 Css NA 1.003 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042208 Css NA 0.1045 mg/L PBTK NA 50% Rat Human -DTXSID4042208 Css NA 0.5833 mg/L PBTK NA 95% Rat Human -DTXSID4042252 Clint NA 17.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042252 Fup NA 0.3035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042252 Vd NA 1.637 L/kg 1compartment NA NA Human Human +DTXSID4042208 TK.Half.Life NA 1.259 hours 1compartment NA NA Rat Human +DTXSID4042208 Css NA 0.03546 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042208 Css NA 0.2168 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042208 Css NA 0.02266 mg/L PBTK NA 50% Rat Human +DTXSID4042208 Css NA 0.1304 mg/L PBTK NA 95% Rat Human +DTXSID4042252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042252 Fup 0.184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042252 Vd NA 1.687 L/kg 1compartment NA NA Human Human DTXSID4042252 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4042252 TK.Half.Life NA 2.584 hours 1compartment NA NA Human Human -DTXSID4042252 Css NA 0.1041 mg/L 3compartmentss NA 50% Human Human -DTXSID4042252 Css NA 0.7241 mg/L 3compartmentss NA 95% Human Human -DTXSID4042252 Css NA 0.07974 mg/L PBTK NA 50% Human Human -DTXSID4042252 Css NA 0.5037 mg/L PBTK NA 95% Human Human -DTXSID4042252 Clint NA 17.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042252 Fup NA 0.3035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4042252 TK.Half.Life NA 3.31 hours 1compartment NA NA Human Human +DTXSID4042252 Css NA 0.1446 mg/L 3compartmentss NA 50% Human Human +DTXSID4042252 Css NA 0.972 mg/L 3compartmentss NA 95% Human Human +DTXSID4042252 Css NA 0.1034 mg/L PBTK NA 50% Human Human +DTXSID4042252 Css NA 0.6487 mg/L PBTK NA 95% Human Human +DTXSID4042252 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042252 Fup 0.184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4042252 Vd NA 1.312 L/kg 1compartment NA NA Rat Human DTXSID4042252 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4042252 TK.Half.Life NA 1.001 hours 1compartment NA NA Rat Human -DTXSID4042252 Css NA 0.05642 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042252 Css NA 0.2904 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042252 Css NA 0.04144 mg/L PBTK NA 50% Rat Human -DTXSID4042252 Css NA 0.1961 mg/L PBTK NA 95% Rat Human -DTXSID4042254 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042254 Fup NA 0.0349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042254 Vd NA 2.935 L/kg 1compartment NA NA Human Human -DTXSID4042254 Days.Css NA 1454 Days PBTK NA NA Human Human -DTXSID4042254 TK.Half.Life NA 5352 hours 1compartment NA NA Human Human -DTXSID4042254 Css NA 222.7 mg/L 3compartmentss NA 50% Human Human -DTXSID4042254 Css NA 630.2 mg/L 3compartmentss NA 95% Human Human -DTXSID4042254 Css NA 152.9 mg/L PBTK NA 50% Human Human -DTXSID4042254 Css NA 403 mg/L PBTK NA 95% Human Human -DTXSID4042254 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042254 Fup NA 0.0349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042254 Vd NA 2.199 L/kg 1compartment NA NA Rat Human -DTXSID4042254 Days.Css NA 368 Days PBTK NA NA Rat Human -DTXSID4042254 TK.Half.Life NA 431.3 hours 1compartment NA NA Rat Human -DTXSID4042254 Css NA 60.34 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042254 Css NA 138 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042254 Css NA 39.56 mg/L PBTK NA 50% Rat Human -DTXSID4042254 Css NA 82.22 mg/L PBTK NA 95% Rat Human -DTXSID4042256 Clint NA 5.836 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042256 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042256 Vd NA 2.025 L/kg 1compartment NA NA Human Human -DTXSID4042256 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID4042256 TK.Half.Life NA 64.84 hours 1compartment NA NA Human Human -DTXSID4042256 Css NA 5.14 mg/L 3compartmentss NA 50% Human Human -DTXSID4042256 Css NA 36.14 mg/L 3compartmentss NA 95% Human Human -DTXSID4042256 Css NA 3.322 mg/L PBTK NA 50% Human Human -DTXSID4042256 Css NA 22.15 mg/L PBTK NA 95% Human Human -DTXSID4042256 Clint NA 5.836 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042256 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042256 Vd NA 1.508 L/kg 1compartment NA NA Rat Human -DTXSID4042256 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID4042256 TK.Half.Life NA 19.87 hours 1compartment NA NA Rat Human -DTXSID4042256 Css NA 2.7 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042256 Css NA 14.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042256 Css NA 1.642 mg/L PBTK NA 50% Rat Human -DTXSID4042256 Css NA 8.488 mg/L PBTK NA 95% Rat Human -DTXSID4042335 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042335 Fup NA 0.6982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042335 Vd NA 1.449 L/kg 1compartment NA NA Human Human -DTXSID4042335 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4042335 TK.Half.Life NA 15.71 hours 1compartment NA NA Human Human -DTXSID4042335 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human -DTXSID4042335 Css NA 7.282 mg/L 3compartmentss NA 95% Human Human -DTXSID4042335 Css NA 0.9791 mg/L PBTK NA 50% Human Human -DTXSID4042335 Css NA 4.755 mg/L PBTK NA 95% Human Human -DTXSID4042335 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042335 Fup NA 0.6982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042335 Vd NA 1.257 L/kg 1compartment NA NA Rat Human +DTXSID4042252 TK.Half.Life NA 1.234 hours 1compartment NA NA Rat Human +DTXSID4042252 Css NA 0.01856 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042252 Css NA 0.09372 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042252 Css NA 0.01316 mg/L PBTK NA 50% Rat Human +DTXSID4042252 Css NA 0.06155 mg/L PBTK NA 95% Rat Human +DTXSID4042254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042254 Fup 0.0128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042254 Vd NA 2.96 L/kg 1compartment NA NA Human Human +DTXSID4042254 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID4042254 TK.Half.Life NA 64.78 hours 1compartment NA NA Human Human +DTXSID4042254 Css NA 1.524 mg/L 3compartmentss NA 50% Human Human +DTXSID4042254 Css NA 10.8 mg/L 3compartmentss NA 95% Human Human +DTXSID4042254 Css NA 1.041 mg/L PBTK NA 50% Human Human +DTXSID4042254 Css NA 7.181 mg/L PBTK NA 95% Human Human +DTXSID4042254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042254 Fup 0.0128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042254 Vd NA 2.215 L/kg 1compartment NA NA Rat Human +DTXSID4042254 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4042254 TK.Half.Life NA 10.74 hours 1compartment NA NA Rat Human +DTXSID4042254 Css NA 0.01664 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042254 Css NA 0.1122 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042254 Css NA 0.01084 mg/L PBTK NA 50% Rat Human +DTXSID4042254 Css NA 0.07008 mg/L PBTK NA 95% Rat Human +DTXSID4042256 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042256 Fup 0.00716 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042256 Vd NA 2.203 L/kg 1compartment NA NA Human Human +DTXSID4042256 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4042256 TK.Half.Life NA 42.5 hours 1compartment NA NA Human Human +DTXSID4042256 Css NA 2.911 mg/L 3compartmentss NA 50% Human Human +DTXSID4042256 Css NA 24.3 mg/L 3compartmentss NA 95% Human Human +DTXSID4042256 Css NA 1.878 mg/L PBTK NA 50% Human Human +DTXSID4042256 Css NA 14.99 mg/L PBTK NA 95% Human Human +DTXSID4042256 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042256 Fup 0.00716 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042256 Vd NA 1.634 L/kg 1compartment NA NA Rat Human +DTXSID4042256 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4042256 TK.Half.Life NA 12.34 hours 1compartment NA NA Rat Human +DTXSID4042256 Css NA 0.3785 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042256 Css NA 2.487 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042256 Css NA 0.2386 mg/L PBTK NA 50% Rat Human +DTXSID4042256 Css NA 1.491 mg/L PBTK NA 95% Rat Human +DTXSID4042335 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042335 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042335 Vd NA 1.247 L/kg 1compartment NA NA Human Human +DTXSID4042335 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4042335 TK.Half.Life NA 1.054 hours 1compartment NA NA Human Human +DTXSID4042335 Css NA 0.02966 mg/L 3compartmentss NA 50% Human Human +DTXSID4042335 Css NA 0.321 mg/L 3compartmentss NA 95% Human Human +DTXSID4042335 Css NA 0.02532 mg/L PBTK NA 50% Human Human +DTXSID4042335 Css NA 0.2273 mg/L PBTK NA 95% Human Human +DTXSID4042335 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042335 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042335 Vd NA 1.11 L/kg 1compartment NA NA Rat Human DTXSID4042335 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4042335 TK.Half.Life NA 4.131 hours 1compartment NA NA Rat Human -DTXSID4042335 Css NA 0.2915 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042335 Css NA 1.868 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042335 Css NA 0.2493 mg/L PBTK NA 50% Rat Human -DTXSID4042335 Css NA 1.138 mg/L PBTK NA 95% Rat Human -DTXSID4042416 Clint NA 1.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042416 Fup NA 0.0186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042416 Vd NA 0.2749 L/kg 1compartment NA NA Human Human -DTXSID4042416 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID4042416 TK.Half.Life NA 32.53 hours 1compartment NA NA Human Human -DTXSID4042416 Css NA 21.03 mg/L 3compartmentss NA 50% Human Human -DTXSID4042416 Css NA 146.5 mg/L 3compartmentss NA 95% Human Human -DTXSID4042416 Css NA 12.42 mg/L PBTK NA 50% Human Human -DTXSID4042416 Css NA 85.23 mg/L PBTK NA 95% Human Human -DTXSID4042416 Clint NA 1.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042416 Fup NA 0.0186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042416 Vd NA 0.2401 L/kg 1compartment NA NA Rat Human -DTXSID4042416 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4042416 TK.Half.Life NA 14.6 hours 1compartment NA NA Rat Human -DTXSID4042416 Css NA 8.955 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042416 Css NA 53.35 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042416 Css NA 4.941 mg/L PBTK NA 50% Rat Human -DTXSID4042416 Css NA 28.93 mg/L PBTK NA 95% Rat Human +DTXSID4042335 TK.Half.Life NA 0.4519 hours 1compartment NA NA Rat Human +DTXSID4042335 Css NA 0.00352 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042335 Css NA 0.03314 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042335 Css NA 0.003083 mg/L PBTK NA 50% Rat Human +DTXSID4042335 Css NA 0.02282 mg/L PBTK NA 95% Rat Human +DTXSID4042416 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042416 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042416 Vd NA 0.5543 L/kg 1compartment NA NA Human Human +DTXSID4042416 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4042416 TK.Half.Life NA 1.395 hours 1compartment NA NA Human Human +DTXSID4042416 Css NA 0.274 mg/L 3compartmentss NA 50% Human Human +DTXSID4042416 Css NA 2.157 mg/L 3compartmentss NA 95% Human Human +DTXSID4042416 Css NA 0.173 mg/L PBTK NA 50% Human Human +DTXSID4042416 Css NA 1.322 mg/L PBTK NA 95% Human Human +DTXSID4042416 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042416 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042416 Vd NA 0.4843 L/kg 1compartment NA NA Rat Human +DTXSID4042416 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4042416 TK.Half.Life NA 0.7133 hours 1compartment NA NA Rat Human +DTXSID4042416 Css NA 0.03518 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042416 Css NA 0.2258 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042416 Css NA 0.02162 mg/L PBTK NA 50% Rat Human +DTXSID4042416 Css NA 0.1313 mg/L PBTK NA 95% Rat Human DTXSID4042418 Clint 43.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4042418 Fup NA 0.0255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042418 Vd NA 0.2937 L/kg 1compartment NA NA Human Human +DTXSID4042418 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042418 Vd NA 0.2843 L/kg 1compartment NA NA Human Human DTXSID4042418 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4042418 TK.Half.Life NA 1.269 hours 1compartment NA NA Human Human -DTXSID4042418 Css NA 0.6467 mg/L 3compartmentss NA 50% Human Human -DTXSID4042418 Css NA 6.389 mg/L 3compartmentss NA 95% Human Human -DTXSID4042418 Css NA 0.3832 mg/L PBTK NA 50% Human Human -DTXSID4042418 Css NA 3.728 mg/L PBTK NA 95% Human Human +DTXSID4042418 TK.Half.Life NA 0.4401 hours 1compartment NA NA Human Human +DTXSID4042418 Css NA 0.1054 mg/L 3compartmentss NA 50% Human Human +DTXSID4042418 Css NA 0.8819 mg/L 3compartmentss NA 95% Human Human +DTXSID4042418 Css NA 0.0653 mg/L PBTK NA 50% Human Human +DTXSID4042418 Css NA 0.5258 mg/L PBTK NA 95% Human Human DTXSID4042418 Clint 43.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4042418 Fup NA 0.0255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042418 Vd NA 0.2565 L/kg 1compartment NA NA Rat Human +DTXSID4042418 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042418 Vd NA 0.2792 L/kg 1compartment NA NA Rat Human DTXSID4042418 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4042418 TK.Half.Life NA 0.7005 hours 1compartment NA NA Rat Human -DTXSID4042418 Css NA 0.369 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042418 Css NA 2.94 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042418 Css NA 0.2047 mg/L PBTK NA 50% Rat Human -DTXSID4042418 Css NA 1.614 mg/L PBTK NA 95% Rat Human -DTXSID4042468 Clint NA 79.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042468 Fup NA 0.3203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042468 Vd NA 1.862 L/kg 1compartment NA NA Human Human +DTXSID4042418 TK.Half.Life NA 0.2335 hours 1compartment NA NA Rat Human +DTXSID4042418 Css NA 0.01393 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042418 Css NA 0.09187 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042418 Css NA 0.008386 mg/L PBTK NA 50% Rat Human +DTXSID4042418 Css NA 0.05411 mg/L PBTK NA 95% Rat Human +DTXSID4042462 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4042462 Fup NA 0.8345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4042462 Vd NA 1.637 L/kg 1compartment NA NA Human Human +DTXSID4042462 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4042462 TK.Half.Life NA 15.13 hours 1compartment NA NA Human Human +DTXSID4042462 Css NA 0.8022 mg/L 3compartmentss NA 50% Human Human +DTXSID4042462 Css NA 5.016 mg/L 3compartmentss NA 95% Human Human +DTXSID4042462 Css NA 0.7494 mg/L PBTK NA 50% Human Human +DTXSID4042462 Css NA 3.415 mg/L PBTK NA 95% Human Human +DTXSID4042462 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4042462 Fup NA 0.8345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4042462 Vd NA 1.441 L/kg 1compartment NA NA Rat Human +DTXSID4042462 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4042462 TK.Half.Life NA 3.984 hours 1compartment NA NA Rat Human +DTXSID4042462 Css NA 0.0146 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042462 Css NA 0.1171 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042462 Css NA 0.01333 mg/L PBTK NA 50% Rat Human +DTXSID4042462 Css NA 0.08199 mg/L PBTK NA 95% Rat Human +DTXSID4042468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042468 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042468 Vd NA 1.669 L/kg 1compartment NA NA Human Human DTXSID4042468 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4042468 TK.Half.Life NA 1.734 hours 1compartment NA NA Human Human -DTXSID4042468 Css NA 0.02555 mg/L 3compartmentss NA 50% Human Human -DTXSID4042468 Css NA 0.1817 mg/L 3compartmentss NA 95% Human Human -DTXSID4042468 Css NA 0.01936 mg/L PBTK NA 50% Human Human -DTXSID4042468 Css NA 0.1274 mg/L PBTK NA 95% Human Human -DTXSID4042468 Clint NA 79.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042468 Fup NA 0.3203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042468 Vd NA 1.458 L/kg 1compartment NA NA Rat Human +DTXSID4042468 TK.Half.Life NA 2.711 hours 1compartment NA NA Human Human +DTXSID4042468 Css NA 0.1049 mg/L 3compartmentss NA 50% Human Human +DTXSID4042468 Css NA 0.7242 mg/L 3compartmentss NA 95% Human Human +DTXSID4042468 Css NA 0.07648 mg/L PBTK NA 50% Human Human +DTXSID4042468 Css NA 0.4991 mg/L PBTK NA 95% Human Human +DTXSID4042468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042468 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042468 Vd NA 1.303 L/kg 1compartment NA NA Rat Human DTXSID4042468 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4042468 TK.Half.Life NA 0.6006 hours 1compartment NA NA Rat Human -DTXSID4042468 Css NA 0.01394 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042468 Css NA 0.08332 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042468 Css NA 0.01017 mg/L PBTK NA 50% Rat Human -DTXSID4042468 Css NA 0.05681 mg/L PBTK NA 95% Rat Human -DTXSID4042622 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042622 Fup NA 0.0671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4042622 Vd NA 0.5392 L/kg 1compartment NA NA Human Human -DTXSID4042622 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4042622 TK.Half.Life NA 3.32 hours 1compartment NA NA Human Human -DTXSID4042622 Css NA 0.9702 mg/L 3compartmentss NA 50% Human Human -DTXSID4042622 Css NA 6.793 mg/L 3compartmentss NA 95% Human Human -DTXSID4042622 Css NA 0.5946 mg/L PBTK NA 50% Human Human -DTXSID4042622 Css NA 3.981 mg/L PBTK NA 95% Human Human -DTXSID4042622 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042622 Fup NA 0.0671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4042622 Vd NA 0.4416 L/kg 1compartment NA NA Rat Human +DTXSID4042468 TK.Half.Life NA 1.002 hours 1compartment NA NA Rat Human +DTXSID4042468 Css NA 0.01308 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042468 Css NA 0.06641 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042468 Css NA 0.009548 mg/L PBTK NA 50% Rat Human +DTXSID4042468 Css NA 0.04603 mg/L PBTK NA 95% Rat Human +DTXSID4042622 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042622 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4042622 Vd NA 2.798 L/kg 1compartment NA NA Human Human +DTXSID4042622 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4042622 TK.Half.Life NA 19.5 hours 1compartment NA NA Human Human +DTXSID4042622 Css NA 0.709 mg/L 3compartmentss NA 50% Human Human +DTXSID4042622 Css NA 3.887 mg/L 3compartmentss NA 95% Human Human +DTXSID4042622 Css NA 0.5275 mg/L PBTK NA 50% Human Human +DTXSID4042622 Css NA 2.762 mg/L PBTK NA 95% Human Human +DTXSID4042622 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042622 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4042622 Vd NA 2.133 L/kg 1compartment NA NA Rat Human DTXSID4042622 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4042622 TK.Half.Life NA 1.666 hours 1compartment NA NA Rat Human -DTXSID4042622 Css NA 0.5295 mg/L 3compartmentss NA 50% Rat Human -DTXSID4042622 Css NA 2.773 mg/L 3compartmentss NA 95% Rat Human -DTXSID4042622 Css NA 0.3041 mg/L PBTK NA 50% Rat Human -DTXSID4042622 Css NA 1.558 mg/L PBTK NA 95% Rat Human -DTXSID4043777 Clint NA 9.739 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4043777 Fup NA 0.3617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4043777 Vd NA 2.702 L/kg 1compartment NA NA Human Human +DTXSID4042622 TK.Half.Life NA 4.068 hours 1compartment NA NA Rat Human +DTXSID4042622 Css NA 0.08656 mg/L 3compartmentss NA 50% Rat Human +DTXSID4042622 Css NA 0.3308 mg/L 3compartmentss NA 95% Rat Human +DTXSID4042622 Css NA 0.06429 mg/L PBTK NA 50% Rat Human +DTXSID4042622 Css NA 0.2331 mg/L PBTK NA 95% Rat Human +DTXSID40431319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40431319 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40431319 Vd NA 8.445 L/kg 1compartment NA NA Human Human +DTXSID40431319 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40431319 TK.Half.Life NA 3.216 hours 1compartment NA NA Human Human +DTXSID40431319 Css NA 0.005962 mg/L 3compartmentss NA 50% Human Human +DTXSID40431319 Css NA 0.0748 mg/L 3compartmentss NA 95% Human Human +DTXSID40431319 Css NA 0.01382 mg/L PBTK NA 50% Human Human +DTXSID40431319 Css NA 0.1124 mg/L PBTK NA 95% Human Human +DTXSID40431319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40431319 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40431319 Vd NA 8.51 L/kg 1compartment NA NA Rat Human +DTXSID40431319 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40431319 TK.Half.Life NA 1.533 hours 1compartment NA NA Rat Human +DTXSID40431319 Css NA 0.0007105 mg/L 3compartmentss NA 50% Rat Human +DTXSID40431319 Css NA 0.007951 mg/L 3compartmentss NA 95% Rat Human +DTXSID40431319 Css NA 0.001792 mg/L PBTK NA 50% Rat Human +DTXSID40431319 Css NA 0.01216 mg/L PBTK NA 95% Rat Human +DTXSID40432386 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40432386 Fup 0.0356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40432386 Vd NA 1.211 L/kg 1compartment NA NA Human Human +DTXSID40432386 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID40432386 TK.Half.Life NA 20.5 hours 1compartment NA NA Human Human +DTXSID40432386 Css NA 2.825 mg/L 3compartmentss NA 50% Human Human +DTXSID40432386 Css NA 18.21 mg/L 3compartmentss NA 95% Human Human +DTXSID40432386 Css NA 1.759 mg/L PBTK NA 50% Human Human +DTXSID40432386 Css NA 10.93 mg/L PBTK NA 95% Human Human +DTXSID40432386 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40432386 Fup 0.0356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40432386 Vd NA 0.9083 L/kg 1compartment NA NA Rat Human +DTXSID40432386 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID40432386 TK.Half.Life NA 8.357 hours 1compartment NA NA Rat Human +DTXSID40432386 Css NA 0.3446 mg/L 3compartmentss NA 50% Rat Human +DTXSID40432386 Css NA 1.73 mg/L 3compartmentss NA 95% Rat Human +DTXSID40432386 Css NA 0.2088 mg/L PBTK NA 50% Rat Human +DTXSID40432386 Css NA 1.004 mg/L PBTK NA 95% Rat Human +DTXSID4043777 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4043777 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4043777 Vd NA 1.909 L/kg 1compartment NA NA Human Human DTXSID4043777 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4043777 TK.Half.Life NA 3.936 hours 1compartment NA NA Human Human -DTXSID4043777 Css NA 0.0853 mg/L 3compartmentss NA 50% Human Human -DTXSID4043777 Css NA 0.6736 mg/L 3compartmentss NA 95% Human Human -DTXSID4043777 Css NA 0.0887 mg/L PBTK NA 50% Human Human -DTXSID4043777 Css NA 0.5591 mg/L PBTK NA 95% Human Human -DTXSID4043777 Clint NA 9.739 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4043777 Fup NA 0.3617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4043777 Vd NA 2.734 L/kg 1compartment NA NA Rat Human +DTXSID4043777 TK.Half.Life NA 5.382 hours 1compartment NA NA Human Human +DTXSID4043777 Css NA 0.219 mg/L 3compartmentss NA 50% Human Human +DTXSID4043777 Css NA 1.438 mg/L 3compartmentss NA 95% Human Human +DTXSID4043777 Css NA 0.1908 mg/L PBTK NA 50% Human Human +DTXSID4043777 Css NA 1.075 mg/L PBTK NA 95% Human Human +DTXSID4043777 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4043777 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4043777 Vd NA 1.918 L/kg 1compartment NA NA Rat Human DTXSID4043777 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4043777 TK.Half.Life NA 2.283 hours 1compartment NA NA Rat Human -DTXSID4043777 Css NA 0.04243 mg/L 3compartmentss NA 50% Rat Human -DTXSID4043777 Css NA 0.2751 mg/L 3compartmentss NA 95% Rat Human -DTXSID4043777 Css NA 0.04424 mg/L PBTK NA 50% Rat Human -DTXSID4043777 Css NA 0.2124 mg/L PBTK NA 95% Rat Human +DTXSID4043777 TK.Half.Life NA 3.196 hours 1compartment NA NA Rat Human +DTXSID4043777 Css NA 0.02565 mg/L 3compartmentss NA 50% Rat Human +DTXSID4043777 Css NA 0.1257 mg/L 3compartmentss NA 95% Rat Human +DTXSID4043777 Css NA 0.02255 mg/L PBTK NA 50% Rat Human +DTXSID4043777 Css NA 0.09126 mg/L PBTK NA 95% Rat Human DTXSID4043802 Clint 10.23 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4043802 Fup 0.3 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID4043802 Vd NA 2.896 L/kg 1compartment NA NA Human Human DTXSID4043802 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID4043802 TK.Half.Life NA 17.83 hours 1compartment NA NA Human Human -DTXSID4043802 Css NA 0.6554 mg/L 3compartmentss NA 50% Human Human -DTXSID4043802 Css NA 3.664 mg/L 3compartmentss NA 95% Human Human -DTXSID4043802 Css NA 0.4784 mg/L PBTK NA 50% Human Human -DTXSID4043802 Css NA 2.559 mg/L PBTK NA 95% Human Human +DTXSID4043802 Css NA 0.6245 mg/L 3compartmentss NA 50% Human Human +DTXSID4043802 Css NA 3.602 mg/L 3compartmentss NA 95% Human Human +DTXSID4043802 Css NA 0.4544 mg/L PBTK NA 50% Human Human +DTXSID4043802 Css NA 2.505 mg/L PBTK NA 95% Human Human DTXSID4043802 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4043802 Fup 0.4 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4043802 Vd NA 2.256 L/kg 1compartment NA NA Rat Rat DTXSID4043802 Days.Css NA 22 Days PBTK NA NA Rat Rat DTXSID4043802 TK.Half.Life NA 34.38 hours 1compartment NA NA Rat Rat -DTXSID4043802 Css NA 3.962 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4043802 Css NA 9.179 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4043802 Css NA 2.818 mg/L PBTK NA 50% Rat Rat -DTXSID4043802 Css NA 5.73 mg/L PBTK NA 95% Rat Rat -DTXSID4043850 Clint NA 2.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4043850 Fup NA 0.6019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4043850 Vd NA 2.82 L/kg 1compartment NA NA Human Human -DTXSID4043850 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4043850 TK.Half.Life NA 6.62 hours 1compartment NA NA Human Human -DTXSID4043850 Css NA 0.1773 mg/L 3compartmentss NA 50% Human Human -DTXSID4043850 Css NA 1.726 mg/L 3compartmentss NA 95% Human Human -DTXSID4043850 Css NA 0.198 mg/L PBTK NA 50% Human Human -DTXSID4043850 Css NA 1.272 mg/L PBTK NA 95% Human Human -DTXSID4043850 Clint NA 2.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4043850 Fup NA 0.6019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4043850 Vd NA 2.856 L/kg 1compartment NA NA Rat Human -DTXSID4043850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4043850 TK.Half.Life NA 3.639 hours 1compartment NA NA Rat Human -DTXSID4043850 Css NA 0.07672 mg/L 3compartmentss NA 50% Rat Human -DTXSID4043850 Css NA 0.6927 mg/L 3compartmentss NA 95% Rat Human -DTXSID4043850 Css NA 0.08582 mg/L PBTK NA 50% Rat Human -DTXSID4043850 Css NA 0.4604 mg/L PBTK NA 95% Rat Human -DTXSID4043937 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4043937 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4043937 Vd NA 0.7537 L/kg 1compartment NA NA Human Human -DTXSID4043937 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4043937 TK.Half.Life NA 4.878 hours 1compartment NA NA Human Human -DTXSID4043937 Css NA 0.8345 mg/L 3compartmentss NA 50% Human Human -DTXSID4043937 Css NA 5.559 mg/L 3compartmentss NA 95% Human Human -DTXSID4043937 Css NA 0.6989 mg/L PBTK NA 50% Human Human -DTXSID4043937 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID4043937 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4043937 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4043937 Vd NA 0.7952 L/kg 1compartment NA NA Rat Human -DTXSID4043937 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4043937 TK.Half.Life NA 1.754 hours 1compartment NA NA Rat Human -DTXSID4043937 Css NA 0.2095 mg/L 3compartmentss NA 50% Rat Human -DTXSID4043937 Css NA 1.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID4043937 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID4043937 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID4044161 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044161 Fup NA 0.4476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044161 Vd NA 2.592 L/kg 1compartment NA NA Human Human -DTXSID4044161 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID4044161 TK.Half.Life NA 107.9 hours 1compartment NA NA Human Human -DTXSID4044161 Css NA 4.372 mg/L 3compartmentss NA 50% Human Human -DTXSID4044161 Css NA 14.41 mg/L 3compartmentss NA 95% Human Human -DTXSID4044161 Css NA 3.463 mg/L PBTK NA 50% Human Human -DTXSID4044161 Css NA 9.92 mg/L PBTK NA 95% Human Human -DTXSID4044161 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044161 Fup NA 0.4476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044161 Vd NA 2.011 L/kg 1compartment NA NA Rat Human -DTXSID4044161 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID4044161 TK.Half.Life NA 14.34 hours 1compartment NA NA Rat Human -DTXSID4044161 Css NA 1.174 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044161 Css NA 3.206 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044161 Css NA 0.8952 mg/L PBTK NA 50% Rat Human -DTXSID4044161 Css NA 2.044 mg/L PBTK NA 95% Rat Human -DTXSID4044371 Clint NA 0.8469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044371 Fup NA 0.8669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044371 Vd NA 0.5638 L/kg 1compartment NA NA Human Human +DTXSID4043802 Css NA 0.8349 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4043802 Css NA 1.988 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4043802 Css NA 0.6178 mg/L PBTK NA 50% Rat Rat +DTXSID4043802 Css NA 1.29 mg/L PBTK NA 95% Rat Rat +DTXSID4044292 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044292 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4044292 Vd NA 0.5568 L/kg 1compartment NA NA Human Human +DTXSID4044292 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4044292 TK.Half.Life NA 10.48 hours 1compartment NA NA Human Human +DTXSID4044292 Css NA 3.26 mg/L 3compartmentss NA 50% Human Human +DTXSID4044292 Css NA 26.52 mg/L 3compartmentss NA 95% Human Human +DTXSID4044292 Css NA 1.963 mg/L PBTK NA 50% Human Human +DTXSID4044292 Css NA 15.79 mg/L PBTK NA 95% Human Human +DTXSID4044292 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044292 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4044292 Vd NA 0.4379 L/kg 1compartment NA NA Rat Human +DTXSID4044292 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044292 TK.Half.Life NA 5.071 hours 1compartment NA NA Rat Human +DTXSID4044292 Css NA 0.407 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044292 Css NA 2.62 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044292 Css NA 0.2368 mg/L PBTK NA 50% Rat Human +DTXSID4044292 Css NA 1.481 mg/L PBTK NA 95% Rat Human +DTXSID4044371 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044371 Fup 0.801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044371 Vd NA 0.8398 L/kg 1compartment NA NA Human Human DTXSID4044371 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044371 TK.Half.Life NA 1.876 hours 1compartment NA NA Human Human -DTXSID4044371 Css NA 0.4325 mg/L 3compartmentss NA 50% Human Human -DTXSID4044371 Css NA 2.574 mg/L 3compartmentss NA 95% Human Human -DTXSID4044371 Css NA 0.3289 mg/L PBTK NA 50% Human Human -DTXSID4044371 Css NA 1.638 mg/L PBTK NA 95% Human Human -DTXSID4044371 Clint NA 0.8469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044371 Fup NA 0.8669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044371 Vd NA 0.5872 L/kg 1compartment NA NA Rat Human +DTXSID4044371 TK.Half.Life NA 6.782 hours 1compartment NA NA Human Human +DTXSID4044371 Css NA 0.9455 mg/L 3compartmentss NA 50% Human Human +DTXSID4044371 Css NA 5.82 mg/L 3compartmentss NA 95% Human Human +DTXSID4044371 Css NA 0.7893 mg/L PBTK NA 50% Human Human +DTXSID4044371 Css NA 3.795 mg/L PBTK NA 95% Human Human +DTXSID4044371 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044371 Fup 0.801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044371 Vd NA 0.8885 L/kg 1compartment NA NA Rat Human DTXSID4044371 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044371 TK.Half.Life NA 0.9159 hours 1compartment NA NA Rat Human -DTXSID4044371 Css NA 0.1575 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044371 Css NA 0.8687 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044371 Css NA 0.1169 mg/L PBTK NA 50% Rat Human -DTXSID4044371 Css NA 0.5099 mg/L PBTK NA 95% Rat Human +DTXSID4044371 TK.Half.Life NA 2.446 hours 1compartment NA NA Rat Human +DTXSID4044371 Css NA 0.05617 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044371 Css NA 0.3343 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044371 Css NA 0.04712 mg/L PBTK NA 50% Rat Human +DTXSID4044371 Css NA 0.2077 mg/L PBTK NA 95% Rat Human DTXSID4044373 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4044373 Fup NA 0.9444 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044373 Vd NA 1.5 L/kg 1compartment NA NA Human Human -DTXSID4044373 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4044373 TK.Half.Life NA 10.27 hours 1compartment NA NA Human Human -DTXSID4044373 Css NA 0.736 mg/L 3compartmentss NA 50% Human Human -DTXSID4044373 Css NA 2.823 mg/L 3compartmentss NA 95% Human Human -DTXSID4044373 Css NA 0.7127 mg/L PBTK NA 50% Human Human -DTXSID4044373 Css NA 2.141 mg/L PBTK NA 95% Human Human +DTXSID4044373 Vd NA 1.26 L/kg 1compartment NA NA Human Human +DTXSID4044373 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044373 TK.Half.Life NA 8.63 hours 1compartment NA NA Human Human +DTXSID4044373 Css NA 0.648 mg/L 3compartmentss NA 50% Human Human +DTXSID4044373 Css NA 2.524 mg/L 3compartmentss NA 95% Human Human +DTXSID4044373 Css NA 0.6089 mg/L PBTK NA 50% Human Human +DTXSID4044373 Css NA 1.908 mg/L PBTK NA 95% Human Human DTXSID4044373 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4044373 Fup NA 0.9444 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044373 Vd NA 1.55 L/kg 1compartment NA NA Rat Human +DTXSID4044373 Vd NA 1.332 L/kg 1compartment NA NA Rat Human DTXSID4044373 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044373 TK.Half.Life NA 3.62 hours 1compartment NA NA Rat Human -DTXSID4044373 Css NA 0.1886 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044373 Css NA 0.672 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044373 Css NA 0.1807 mg/L PBTK NA 50% Rat Human -DTXSID4044373 Css NA 0.4707 mg/L PBTK NA 95% Rat Human -DTXSID4044375 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044375 Fup NA 0.9711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044375 Vd NA 0.9767 L/kg 1compartment NA NA Human Human +DTXSID4044373 TK.Half.Life NA 3.11 hours 1compartment NA NA Rat Human +DTXSID4044373 Css NA 0.01168 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044373 Css NA 0.06245 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044373 Css NA 0.01076 mg/L PBTK NA 50% Rat Human +DTXSID4044373 Css NA 0.04994 mg/L PBTK NA 95% Rat Human +DTXSID4044375 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044375 Fup 0.838 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044375 Vd NA 1.062 L/kg 1compartment NA NA Human Human DTXSID4044375 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044375 TK.Half.Life NA 6.521 hours 1compartment NA NA Human Human -DTXSID4044375 Css NA 0.8098 mg/L 3compartmentss NA 50% Human Human -DTXSID4044375 Css NA 2.822 mg/L 3compartmentss NA 95% Human Human -DTXSID4044375 Css NA 0.7078 mg/L PBTK NA 50% Human Human -DTXSID4044375 Css NA 2.083 mg/L PBTK NA 95% Human Human -DTXSID4044375 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044375 Fup NA 0.9711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044375 Vd NA 0.9993 L/kg 1compartment NA NA Rat Human +DTXSID4044375 TK.Half.Life NA 8.29 hours 1compartment NA NA Human Human +DTXSID4044375 Css NA 0.8808 mg/L 3compartmentss NA 50% Human Human +DTXSID4044375 Css NA 5.653 mg/L 3compartmentss NA 95% Human Human +DTXSID4044375 Css NA 0.7759 mg/L PBTK NA 50% Human Human +DTXSID4044375 Css NA 3.716 mg/L PBTK NA 95% Human Human +DTXSID4044375 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044375 Fup 0.838 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044375 Vd NA 1.061 L/kg 1compartment NA NA Rat Human DTXSID4044375 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044375 TK.Half.Life NA 2.27 hours 1compartment NA NA Rat Human -DTXSID4044375 Css NA 0.2058 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044375 Css NA 0.6394 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044375 Css NA 0.1764 mg/L PBTK NA 50% Rat Human -DTXSID4044375 Css NA 0.4288 mg/L PBTK NA 95% Rat Human -DTXSID4044379 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044379 Fup NA 0.3662 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044379 Vd NA 2.983 L/kg 1compartment NA NA Human Human -DTXSID4044379 Days.Css NA 109 Days PBTK NA NA Human Human -DTXSID4044379 TK.Half.Life NA 468.3 hours 1compartment NA NA Human Human -DTXSID4044379 Css NA 17.08 mg/L 3compartmentss NA 50% Human Human -DTXSID4044379 Css NA 48.87 mg/L 3compartmentss NA 95% Human Human -DTXSID4044379 Css NA 12.6 mg/L PBTK NA 50% Human Human -DTXSID4044379 Css NA 32.73 mg/L PBTK NA 95% Human Human -DTXSID4044379 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044379 Fup NA 0.3662 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044379 Vd NA 2.262 L/kg 1compartment NA NA Rat Human -DTXSID4044379 Days.Css NA 26 Days PBTK NA NA Rat Human -DTXSID4044379 TK.Half.Life NA 39.23 hours 1compartment NA NA Rat Human -DTXSID4044379 Css NA 4.627 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044379 Css NA 10.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044379 Css NA 3.269 mg/L PBTK NA 50% Rat Human -DTXSID4044379 Css NA 6.66 mg/L PBTK NA 95% Rat Human -DTXSID4044402 Clint NA 3.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044402 Fup NA 0.6839 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044402 Vd NA 1.468 L/kg 1compartment NA NA Human Human -DTXSID4044402 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044402 TK.Half.Life NA 3.122 hours 1compartment NA NA Human Human -DTXSID4044402 Css NA 0.1867 mg/L 3compartmentss NA 50% Human Human -DTXSID4044402 Css NA 1.53 mg/L 3compartmentss NA 95% Human Human -DTXSID4044402 Css NA 0.1651 mg/L PBTK NA 50% Human Human -DTXSID4044402 Css NA 1.037 mg/L PBTK NA 95% Human Human -DTXSID4044402 Clint NA 3.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044402 Fup NA 0.6839 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044402 Vd NA 1.29 L/kg 1compartment NA NA Rat Human +DTXSID4044375 TK.Half.Life NA 2.799 hours 1compartment NA NA Rat Human +DTXSID4044375 Css NA 0.05211 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044375 Css NA 0.3133 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044375 Css NA 0.0462 mg/L PBTK NA 50% Rat Human +DTXSID4044375 Css NA 0.1992 mg/L PBTK NA 95% Rat Human +DTXSID4044402 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044402 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044402 Vd NA 1.184 L/kg 1compartment NA NA Human Human +DTXSID4044402 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4044402 TK.Half.Life NA 12.54 hours 1compartment NA NA Human Human +DTXSID4044402 Css NA 1.074 mg/L 3compartmentss NA 50% Human Human +DTXSID4044402 Css NA 7.442 mg/L 3compartmentss NA 95% Human Human +DTXSID4044402 Css NA 0.9328 mg/L PBTK NA 50% Human Human +DTXSID4044402 Css NA 4.786 mg/L PBTK NA 95% Human Human +DTXSID4044402 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044402 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044402 Vd NA 1.082 L/kg 1compartment NA NA Rat Human DTXSID4044402 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044402 TK.Half.Life NA 1.363 hours 1compartment NA NA Rat Human -DTXSID4044402 Css NA 0.08302 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044402 Css NA 0.6291 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044402 Css NA 0.07241 mg/L PBTK NA 50% Rat Human -DTXSID4044402 Css NA 0.3914 mg/L PBTK NA 95% Rat Human -DTXSID4044404 Clint NA 3.394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044404 Fup NA 0.8933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044404 Vd NA 1.221 L/kg 1compartment NA NA Human Human +DTXSID4044402 TK.Half.Life NA 3.703 hours 1compartment NA NA Rat Human +DTXSID4044402 Css NA 0.06432 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044402 Css NA 0.4115 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044402 Css NA 0.05644 mg/L PBTK NA 50% Rat Human +DTXSID4044402 Css NA 0.2587 mg/L PBTK NA 95% Rat Human +DTXSID4044404 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044404 Fup 0.543 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044404 Vd NA 0.6128 L/kg 1compartment NA NA Human Human DTXSID4044404 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044404 TK.Half.Life NA 1.862 hours 1compartment NA NA Human Human -DTXSID4044404 Css NA 0.1372 mg/L 3compartmentss NA 50% Human Human -DTXSID4044404 Css NA 1.084 mg/L 3compartmentss NA 95% Human Human -DTXSID4044404 Css NA 0.1214 mg/L PBTK NA 50% Human Human -DTXSID4044404 Css NA 0.7654 mg/L PBTK NA 95% Human Human -DTXSID4044404 Clint NA 3.394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044404 Fup NA 0.8933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044404 Vd NA 1.155 L/kg 1compartment NA NA Rat Human +DTXSID4044404 TK.Half.Life NA 7.316 hours 1compartment NA NA Human Human +DTXSID4044404 Css NA 1.332 mg/L 3compartmentss NA 50% Human Human +DTXSID4044404 Css NA 8.332 mg/L 3compartmentss NA 95% Human Human +DTXSID4044404 Css NA 1.022 mg/L PBTK NA 50% Human Human +DTXSID4044404 Css NA 5.225 mg/L PBTK NA 95% Human Human +DTXSID4044404 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044404 Fup 0.543 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044404 Vd NA 0.6269 L/kg 1compartment NA NA Rat Human DTXSID4044404 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044404 TK.Half.Life NA 0.9112 hours 1compartment NA NA Rat Human -DTXSID4044404 Css NA 0.06112 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044404 Css NA 0.3894 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044404 Css NA 0.05437 mg/L PBTK NA 50% Rat Human -DTXSID4044404 Css NA 0.2519 mg/L PBTK NA 95% Rat Human -DTXSID4044408 Clint NA 0.1154 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044408 Fup NA 0.8381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044408 Vd NA 2.062 L/kg 1compartment NA NA Human Human +DTXSID4044404 TK.Half.Life NA 2.547 hours 1compartment NA NA Rat Human +DTXSID4044404 Css NA 0.08233 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044404 Css NA 0.4485 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044404 Css NA 0.06301 mg/L PBTK NA 50% Rat Human +DTXSID4044404 Css NA 0.2721 mg/L PBTK NA 95% Rat Human +DTXSID4044408 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044408 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044408 Vd NA 1.596 L/kg 1compartment NA NA Human Human DTXSID4044408 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4044408 TK.Half.Life NA 13.39 hours 1compartment NA NA Human Human -DTXSID4044408 Css NA 0.63 mg/L 3compartmentss NA 50% Human Human -DTXSID4044408 Css NA 4.283 mg/L 3compartmentss NA 95% Human Human -DTXSID4044408 Css NA 0.6505 mg/L PBTK NA 50% Human Human -DTXSID4044408 Css NA 3.011 mg/L PBTK NA 95% Human Human -DTXSID4044408 Clint NA 0.1154 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044408 Fup NA 0.8381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044408 Vd NA 2.092 L/kg 1compartment NA NA Rat Human +DTXSID4044408 TK.Half.Life NA 14.65 hours 1compartment NA NA Human Human +DTXSID4044408 Css NA 0.9003 mg/L 3compartmentss NA 50% Human Human +DTXSID4044408 Css NA 6.555 mg/L 3compartmentss NA 95% Human Human +DTXSID4044408 Css NA 0.8563 mg/L PBTK NA 50% Human Human +DTXSID4044408 Css NA 4.343 mg/L PBTK NA 95% Human Human +DTXSID4044408 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044408 Fup 0.705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044408 Vd NA 1.621 L/kg 1compartment NA NA Rat Human DTXSID4044408 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044408 TK.Half.Life NA 5.041 hours 1compartment NA NA Rat Human -DTXSID4044408 Css NA 0.1748 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044408 Css NA 1.246 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044408 Css NA 0.1792 mg/L PBTK NA 50% Rat Human -DTXSID4044408 Css NA 0.8083 mg/L PBTK NA 95% Rat Human -DTXSID4044454 Clint NA 0.2117 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044454 Fup NA 0.7361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044454 Vd NA 0.8176 L/kg 1compartment NA NA Human Human +DTXSID4044408 TK.Half.Life NA 5.071 hours 1compartment NA NA Rat Human +DTXSID4044408 Css NA 0.05282 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044408 Css NA 0.3621 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044408 Css NA 0.05122 mg/L PBTK NA 50% Rat Human +DTXSID4044408 Css NA 0.2351 mg/L PBTK NA 95% Rat Human +DTXSID4044450 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044450 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044450 Vd NA 1.694 L/kg 1compartment NA NA Human Human +DTXSID4044450 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044450 TK.Half.Life NA 2.25 hours 1compartment NA NA Human Human +DTXSID4044450 Css NA 0.07262 mg/L 3compartmentss NA 50% Human Human +DTXSID4044450 Css NA 0.5128 mg/L 3compartmentss NA 95% Human Human +DTXSID4044450 Css NA 0.05628 mg/L PBTK NA 50% Human Human +DTXSID4044450 Css NA 0.3639 mg/L PBTK NA 95% Human Human +DTXSID4044450 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044450 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044450 Vd NA 1.362 L/kg 1compartment NA NA Rat Human +DTXSID4044450 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044450 TK.Half.Life NA 0.8567 hours 1compartment NA NA Rat Human +DTXSID4044450 Css NA 0.008865 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044450 Css NA 0.0499 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044450 Css NA 0.006894 mg/L PBTK NA 50% Rat Human +DTXSID4044450 Css NA 0.0355 mg/L PBTK NA 95% Rat Human +DTXSID4044454 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044454 Fup 0.689 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044454 Vd NA 1.043 L/kg 1compartment NA NA Human Human DTXSID4044454 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044454 TK.Half.Life NA 5.398 hours 1compartment NA NA Human Human -DTXSID4044454 Css NA 0.7426 mg/L 3compartmentss NA 50% Human Human -DTXSID4044454 Css NA 4.777 mg/L 3compartmentss NA 95% Human Human -DTXSID4044454 Css NA 0.6228 mg/L PBTK NA 50% Human Human -DTXSID4044454 Css NA 3.054 mg/L PBTK NA 95% Human Human -DTXSID4044454 Clint NA 0.2117 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044454 Fup NA 0.7361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044454 Vd NA 0.8167 L/kg 1compartment NA NA Rat Human +DTXSID4044454 TK.Half.Life NA 0.8577 hours 1compartment NA NA Human Human +DTXSID4044454 Css NA 0.02855 mg/L 3compartmentss NA 50% Human Human +DTXSID4044454 Css NA 0.3196 mg/L 3compartmentss NA 95% Human Human +DTXSID4044454 Css NA 0.02407 mg/L PBTK NA 50% Human Human +DTXSID4044454 Css NA 0.2247 mg/L PBTK NA 95% Human Human +DTXSID4044454 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044454 Fup 0.689 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044454 Vd NA 0.9857 L/kg 1compartment NA NA Rat Human DTXSID4044454 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044454 TK.Half.Life NA 2.099 hours 1compartment NA NA Rat Human -DTXSID4044454 Css NA 0.2272 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044454 Css NA 1.424 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044454 Css NA 0.1833 mg/L PBTK NA 50% Rat Human -DTXSID4044454 Css NA 0.8521 mg/L PBTK NA 95% Rat Human +DTXSID4044454 TK.Half.Life NA 0.3961 hours 1compartment NA NA Rat Human +DTXSID4044454 Css NA 0.003375 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044454 Css NA 0.03401 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044454 Css NA 0.002952 mg/L PBTK NA 50% Rat Human +DTXSID4044454 Css NA 0.023 mg/L PBTK NA 95% Rat Human DTXSID4044456 Clint NA 0.032 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4044456 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4044456 Vd NA 1.153 L/kg 1compartment NA NA Human Human DTXSID4044456 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4044456 TK.Half.Life NA 7.079 hours 1compartment NA NA Human Human -DTXSID4044456 Css NA 0.7304 mg/L 3compartmentss NA 50% Human Human -DTXSID4044456 Css NA 5.076 mg/L 3compartmentss NA 95% Human Human -DTXSID4044456 Css NA 0.655 mg/L PBTK NA 50% Human Human -DTXSID4044456 Css NA 3.445 mg/L PBTK NA 95% Human Human +DTXSID4044456 Css NA 0.6202 mg/L 3compartmentss NA 50% Human Human +DTXSID4044456 Css NA 4.156 mg/L 3compartmentss NA 95% Human Human +DTXSID4044456 Css NA 0.556 mg/L PBTK NA 50% Human Human +DTXSID4044456 Css NA 2.808 mg/L PBTK NA 95% Human Human DTXSID4044456 Clint NA 0.032 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4044456 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4044456 Vd NA 1.195 L/kg 1compartment NA NA Rat Human DTXSID4044456 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4044456 TK.Half.Life NA 2.567 hours 1compartment NA NA Rat Human -DTXSID4044456 Css NA 0.1908 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044456 Css NA 1.256 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044456 Css NA 0.1685 mg/L PBTK NA 50% Rat Human -DTXSID4044456 Css NA 0.7719 mg/L PBTK NA 95% Rat Human -DTXSID4044458 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044458 Fup NA 0.9574 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044458 Vd NA 0.7523 L/kg 1compartment NA NA Human Human +DTXSID4044456 Css NA 0.01166 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044456 Css NA 0.1019 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044456 Css NA 0.01022 mg/L PBTK NA 50% Rat Human +DTXSID4044456 Css NA 0.06785 mg/L PBTK NA 95% Rat Human +DTXSID4044458 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044458 Fup 0.739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044458 Vd NA 0.5586 L/kg 1compartment NA NA Human Human DTXSID4044458 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044458 TK.Half.Life NA 5.089 hours 1compartment NA NA Human Human -DTXSID4044458 Css NA 0.9 mg/L 3compartmentss NA 50% Human Human -DTXSID4044458 Css NA 4.843 mg/L 3compartmentss NA 95% Human Human -DTXSID4044458 Css NA 0.7456 mg/L PBTK NA 50% Human Human -DTXSID4044458 Css NA 3.142 mg/L PBTK NA 95% Human Human -DTXSID4044458 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044458 Fup NA 0.9574 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044458 Vd NA 0.7841 L/kg 1compartment NA NA Rat Human +DTXSID4044458 TK.Half.Life NA 4.892 hours 1compartment NA NA Human Human +DTXSID4044458 Css NA 0.9434 mg/L 3compartmentss NA 50% Human Human +DTXSID4044458 Css NA 6.002 mg/L 3compartmentss NA 95% Human Human +DTXSID4044458 Css NA 0.7365 mg/L PBTK NA 50% Human Human +DTXSID4044458 Css NA 3.773 mg/L PBTK NA 95% Human Human +DTXSID4044458 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044458 Fup 0.739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044458 Vd NA 0.6053 L/kg 1compartment NA NA Rat Human DTXSID4044458 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4044458 TK.Half.Life NA 1.806 hours 1compartment NA NA Rat Human -DTXSID4044458 Css NA 0.2281 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044458 Css NA 1.259 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044458 Css NA 0.1834 mg/L PBTK NA 50% Rat Human -DTXSID4044458 Css NA 0.7601 mg/L PBTK NA 95% Rat Human -DTXSID4044535 Clint NA 0.4903 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044535 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044535 Vd NA 0.2717 L/kg 1compartment NA NA Human Human -DTXSID4044535 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4044535 TK.Half.Life NA 24.07 hours 1compartment NA NA Human Human -DTXSID4044535 Css NA 14.99 mg/L 3compartmentss NA 50% Human Human -DTXSID4044535 Css NA 90.69 mg/L 3compartmentss NA 95% Human Human -DTXSID4044535 Css NA 9.08 mg/L PBTK NA 50% Human Human -DTXSID4044535 Css NA 53.29 mg/L PBTK NA 95% Human Human -DTXSID4044535 Clint NA 0.4903 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044535 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044535 Vd NA 0.2669 L/kg 1compartment NA NA Rat Human -DTXSID4044535 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4044535 TK.Half.Life NA 10.46 hours 1compartment NA NA Rat Human -DTXSID4044535 Css NA 5.67 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044535 Css NA 28.65 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044535 Css NA 3.196 mg/L PBTK NA 50% Rat Human -DTXSID4044535 Css NA 15.61 mg/L PBTK NA 95% Rat Human -DTXSID4044537 Clint NA 7.143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044537 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044537 Vd NA 0.2506 L/kg 1compartment NA NA Human Human -DTXSID4044537 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4044537 TK.Half.Life NA 25.31 hours 1compartment NA NA Human Human -DTXSID4044537 Css NA 18.87 mg/L 3compartmentss NA 50% Human Human -DTXSID4044537 Css NA 165.2 mg/L 3compartmentss NA 95% Human Human -DTXSID4044537 Css NA 11.18 mg/L PBTK NA 50% Human Human -DTXSID4044537 Css NA 96.07 mg/L PBTK NA 95% Human Human -DTXSID4044537 Clint NA 7.143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044537 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044537 Vd NA 0.2332 L/kg 1compartment NA NA Rat Human -DTXSID4044537 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4044537 TK.Half.Life NA 15.25 hours 1compartment NA NA Rat Human -DTXSID4044537 Css NA 10.25 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044537 Css NA 68.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044537 Css NA 5.656 mg/L PBTK NA 50% Rat Human -DTXSID4044537 Css NA 36.95 mg/L PBTK NA 95% Rat Human +DTXSID4044458 Css NA 0.0249 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044458 Css NA 0.1791 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044458 Css NA 0.01875 mg/L PBTK NA 50% Rat Human +DTXSID4044458 Css NA 0.1119 mg/L PBTK NA 95% Rat Human +DTXSID4044535 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044535 Fup 0.079 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044535 Vd NA 0.3206 L/kg 1compartment NA NA Human Human +DTXSID4044535 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044535 TK.Half.Life NA 2.548 hours 1compartment NA NA Human Human +DTXSID4044535 Css NA 0.6495 mg/L 3compartmentss NA 50% Human Human +DTXSID4044535 Css NA 5.07 mg/L 3compartmentss NA 95% Human Human +DTXSID4044535 Css NA 0.4032 mg/L PBTK NA 50% Human Human +DTXSID4044535 Css NA 3.042 mg/L PBTK NA 95% Human Human +DTXSID4044535 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044535 Fup 0.079 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044535 Vd NA 0.3175 L/kg 1compartment NA NA Rat Human +DTXSID4044535 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044535 TK.Half.Life NA 1.555 hours 1compartment NA NA Rat Human +DTXSID4044535 Css NA 0.006674 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044535 Css NA 0.04245 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044535 Css NA 0.003888 mg/L PBTK NA 50% Rat Human +DTXSID4044535 Css NA 0.02392 mg/L PBTK NA 95% Rat Human DTXSID4044581 Clint 102 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4044581 Fup 0.0454 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4044581 Vd NA 2.476 L/kg 1compartment NA NA Human Human +DTXSID4044581 Vd NA 2.582 L/kg 1compartment NA NA Human Human DTXSID4044581 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044581 TK.Half.Life NA 5.594 hours 1compartment NA NA Human Human -DTXSID4044581 Css NA 0.1855 mg/L 3compartmentss NA 50% Human Human -DTXSID4044581 Css NA 1.277 mg/L 3compartmentss NA 95% Human Human -DTXSID4044581 Css NA 0.1254 mg/L PBTK NA 50% Human Human -DTXSID4044581 Css NA 0.8209 mg/L PBTK NA 95% Human Human +DTXSID4044581 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human +DTXSID4044581 Css NA 0.1946 mg/L 3compartmentss NA 50% Human Human +DTXSID4044581 Css NA 1.339 mg/L 3compartmentss NA 95% Human Human +DTXSID4044581 Css NA 0.1325 mg/L PBTK NA 50% Human Human +DTXSID4044581 Css NA 0.8847 mg/L PBTK NA 95% Human Human DTXSID4044581 Clint 102 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4044581 Fup 0.0454 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4044581 Vd NA 1.854 L/kg 1compartment NA NA Rat Human +DTXSID4044581 Vd NA 1.933 L/kg 1compartment NA NA Rat Human DTXSID4044581 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044581 TK.Half.Life NA 1.56 hours 1compartment NA NA Rat Human -DTXSID4044581 Css NA 0.1066 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044581 Css NA 0.5721 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044581 Css NA 0.06886 mg/L PBTK NA 50% Rat Human -DTXSID4044581 Css NA 0.3573 mg/L PBTK NA 95% Rat Human -DTXSID4044585 Clint NA 5.822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044585 Fup NA 0.0952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044585 Vd NA 0.2631 L/kg 1compartment NA NA Human Human +DTXSID4044581 TK.Half.Life NA 1.636 hours 1compartment NA NA Rat Human +DTXSID4044581 Css NA 0.02568 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044581 Css NA 0.1547 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044581 Css NA 0.01724 mg/L PBTK NA 50% Rat Human +DTXSID4044581 Css NA 0.102 mg/L PBTK NA 95% Rat Human +DTXSID4044585 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044585 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044585 Vd NA 0.2756 L/kg 1compartment NA NA Human Human DTXSID4044585 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044585 TK.Half.Life NA 1.878 hours 1compartment NA NA Human Human -DTXSID4044585 Css NA 1.102 mg/L 3compartmentss NA 50% Human Human -DTXSID4044585 Css NA 7.374 mg/L 3compartmentss NA 95% Human Human -DTXSID4044585 Css NA 0.6706 mg/L PBTK NA 50% Human Human -DTXSID4044585 Css NA 4.364 mg/L PBTK NA 95% Human Human -DTXSID4044585 Clint NA 5.822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044585 Fup NA 0.0952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044585 Vd NA 0.2569 L/kg 1compartment NA NA Rat Human +DTXSID4044585 TK.Half.Life NA 1.762 hours 1compartment NA NA Human Human +DTXSID4044585 Css NA 0.9399 mg/L 3compartmentss NA 50% Human Human +DTXSID4044585 Css NA 6.294 mg/L 3compartmentss NA 95% Human Human +DTXSID4044585 Css NA 0.5756 mg/L PBTK NA 50% Human Human +DTXSID4044585 Css NA 3.743 mg/L PBTK NA 95% Human Human +DTXSID4044585 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044585 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044585 Vd NA 0.2679 L/kg 1compartment NA NA Rat Human DTXSID4044585 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044585 TK.Half.Life NA 1.117 hours 1compartment NA NA Rat Human -DTXSID4044585 Css NA 0.5792 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044585 Css NA 2.888 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044585 Css NA 0.3312 mg/L PBTK NA 50% Rat Human -DTXSID4044585 Css NA 1.591 mg/L PBTK NA 95% Rat Human -DTXSID4044589 Clint NA 0.02062 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044589 Fup NA 0.5238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044589 Vd NA 0.4131 L/kg 1compartment NA NA Human Human +DTXSID4044585 TK.Half.Life NA 1.043 hours 1compartment NA NA Rat Human +DTXSID4044585 Css NA 0.1145 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044585 Css NA 0.5914 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044585 Css NA 0.06814 mg/L PBTK NA 50% Rat Human +DTXSID4044585 Css NA 0.3381 mg/L PBTK NA 95% Rat Human +DTXSID4044587 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044587 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044587 Vd NA 1.475 L/kg 1compartment NA NA Human Human +DTXSID4044587 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044587 TK.Half.Life NA 1.628 hours 1compartment NA NA Human Human +DTXSID4044587 Css NA 0.04964 mg/L 3compartmentss NA 50% Human Human +DTXSID4044587 Css NA 0.3937 mg/L 3compartmentss NA 95% Human Human +DTXSID4044587 Css NA 0.03989 mg/L PBTK NA 50% Human Human +DTXSID4044587 Css NA 0.2779 mg/L PBTK NA 95% Human Human +DTXSID4044587 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044587 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044587 Vd NA 1.232 L/kg 1compartment NA NA Rat Human +DTXSID4044587 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044587 TK.Half.Life NA 0.6601 hours 1compartment NA NA Rat Human +DTXSID4044587 Css NA 0.006012 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044587 Css NA 0.03698 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044587 Css NA 0.00488 mg/L PBTK NA 50% Rat Human +DTXSID4044587 Css NA 0.02636 mg/L PBTK NA 95% Rat Human +DTXSID4044589 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044589 Fup 0.887 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044589 Vd NA 0.5452 L/kg 1compartment NA NA Human Human DTXSID4044589 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044589 TK.Half.Life NA 4.933 hours 1compartment NA NA Human Human -DTXSID4044589 Css NA 1.437 mg/L 3compartmentss NA 50% Human Human -DTXSID4044589 Css NA 7.406 mg/L 3compartmentss NA 95% Human Human -DTXSID4044589 Css NA 1.036 mg/L PBTK NA 50% Human Human -DTXSID4044589 Css NA 4.571 mg/L PBTK NA 95% Human Human -DTXSID4044589 Clint NA 0.02062 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044589 Fup NA 0.5238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044589 Vd NA 0.4234 L/kg 1compartment NA NA Rat Human +DTXSID4044589 TK.Half.Life NA 3.977 hours 1compartment NA NA Human Human +DTXSID4044589 Css NA 0.9715 mg/L 3compartmentss NA 50% Human Human +DTXSID4044589 Css NA 5.368 mg/L 3compartmentss NA 95% Human Human +DTXSID4044589 Css NA 0.7503 mg/L PBTK NA 50% Human Human +DTXSID4044589 Css NA 3.397 mg/L PBTK NA 95% Human Human +DTXSID4044589 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044589 Fup 0.887 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044589 Vd NA 0.561 L/kg 1compartment NA NA Rat Human DTXSID4044589 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044589 TK.Half.Life NA 1.753 hours 1compartment NA NA Rat Human -DTXSID4044589 Css NA 0.3994 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044589 Css NA 1.938 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044589 Css NA 0.2717 mg/L PBTK NA 50% Rat Human -DTXSID4044589 Css NA 1.113 mg/L PBTK NA 95% Rat Human -DTXSID4044618 Clint NA 50.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044618 Fup NA 0.2427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044618 Vd NA 2.515 L/kg 1compartment NA NA Human Human -DTXSID4044618 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044618 TK.Half.Life NA 3.677 hours 1compartment NA NA Human Human -DTXSID4044618 Css NA 0.08671 mg/L 3compartmentss NA 50% Human Human -DTXSID4044618 Css NA 0.5588 mg/L 3compartmentss NA 95% Human Human -DTXSID4044618 Css NA 0.06386 mg/L PBTK NA 50% Human Human -DTXSID4044618 Css NA 0.3929 mg/L PBTK NA 95% Human Human -DTXSID4044618 Clint NA 50.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044618 Fup NA 0.2427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044618 Vd NA 1.923 L/kg 1compartment NA NA Rat Human -DTXSID4044618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044618 TK.Half.Life NA 1.087 hours 1compartment NA NA Rat Human -DTXSID4044618 Css NA 0.04758 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044618 Css NA 0.2574 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044618 Css NA 0.03377 mg/L PBTK NA 50% Rat Human -DTXSID4044618 Css NA 0.1718 mg/L PBTK NA 95% Rat Human +DTXSID4044589 TK.Half.Life NA 1.394 hours 1compartment NA NA Rat Human +DTXSID4044589 Css NA 0.05808 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044589 Css NA 0.303 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044589 Css NA 0.04467 mg/L PBTK NA 50% Rat Human +DTXSID4044589 Css NA 0.1848 mg/L PBTK NA 95% Rat Human DTXSID4044660 Clint NA 5.207 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4044660 Fup NA 0.6455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044660 Vd NA 2.372 L/kg 1compartment NA NA Human Human +DTXSID4044660 Vd NA 2.902 L/kg 1compartment NA NA Human Human DTXSID4044660 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044660 TK.Half.Life NA 4.313 hours 1compartment NA NA Human Human -DTXSID4044660 Css NA 0.136 mg/L 3compartmentss NA 50% Human Human -DTXSID4044660 Css NA 1.183 mg/L 3compartmentss NA 95% Human Human -DTXSID4044660 Css NA 0.1291 mg/L PBTK NA 50% Human Human -DTXSID4044660 Css NA 0.8696 mg/L PBTK NA 95% Human Human +DTXSID4044660 TK.Half.Life NA 7.657 hours 1compartment NA NA Human Human +DTXSID4044660 Css NA 0.2133 mg/L 3compartmentss NA 50% Human Human +DTXSID4044660 Css NA 1.535 mg/L 3compartmentss NA 95% Human Human +DTXSID4044660 Css NA 0.1905 mg/L PBTK NA 50% Human Human +DTXSID4044660 Css NA 1.173 mg/L PBTK NA 95% Human Human DTXSID4044660 Clint NA 5.207 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4044660 Fup NA 0.6455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044660 Vd NA 2.095 L/kg 1compartment NA NA Rat Human +DTXSID4044660 Vd NA 2.421 L/kg 1compartment NA NA Rat Human DTXSID4044660 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044660 TK.Half.Life NA 1.765 hours 1compartment NA NA Rat Human -DTXSID4044660 Css NA 0.06457 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044660 Css NA 0.4635 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044660 Css NA 0.06094 mg/L PBTK NA 50% Rat Human -DTXSID4044660 Css NA 0.3135 mg/L PBTK NA 95% Rat Human -DTXSID4044664 Clint NA 11.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044664 Fup NA 0.1849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044664 Vd NA 0.3759 L/kg 1compartment NA NA Human Human +DTXSID4044660 TK.Half.Life NA 2.31 hours 1compartment NA NA Rat Human +DTXSID4044660 Css NA 0.02438 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044660 Css NA 0.1292 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044660 Css NA 0.0223 mg/L PBTK NA 50% Rat Human +DTXSID4044660 Css NA 0.09212 mg/L PBTK NA 95% Rat Human +DTXSID4044664 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044664 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044664 Vd NA 0.435 L/kg 1compartment NA NA Human Human DTXSID4044664 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044664 TK.Half.Life NA 0.9269 hours 1compartment NA NA Human Human -DTXSID4044664 Css NA 0.2303 mg/L 3compartmentss NA 50% Human Human -DTXSID4044664 Css NA 1.458 mg/L 3compartmentss NA 95% Human Human -DTXSID4044664 Css NA 0.1501 mg/L PBTK NA 50% Human Human -DTXSID4044664 Css NA 0.9098 mg/L PBTK NA 95% Human Human -DTXSID4044664 Clint NA 11.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044664 Fup NA 0.1849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044664 Vd NA 0.3588 L/kg 1compartment NA NA Rat Human +DTXSID4044664 TK.Half.Life NA 1.244 hours 1compartment NA NA Human Human +DTXSID4044664 Css NA 0.2684 mg/L 3compartmentss NA 50% Human Human +DTXSID4044664 Css NA 1.617 mg/L 3compartmentss NA 95% Human Human +DTXSID4044664 Css NA 0.1812 mg/L PBTK NA 50% Human Human +DTXSID4044664 Css NA 1.028 mg/L PBTK NA 95% Human Human +DTXSID4044664 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044664 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044664 Vd NA 0.4169 L/kg 1compartment NA NA Rat Human DTXSID4044664 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044664 TK.Half.Life NA 0.5138 hours 1compartment NA NA Rat Human -DTXSID4044664 Css NA 0.1245 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044664 Css NA 0.5977 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044664 Css NA 0.07645 mg/L PBTK NA 50% Rat Human -DTXSID4044664 Css NA 0.3563 mg/L PBTK NA 95% Rat Human -DTXSID4044668 Clint NA 2.453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044668 Fup NA 0.0702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044668 Vd NA 2.695 L/kg 1compartment NA NA Human Human -DTXSID4044668 Days.Css NA 24 Days PBTK NA NA Human Human -DTXSID4044668 TK.Half.Life NA 130.2 hours 1compartment NA NA Human Human -DTXSID4044668 Css NA 6.416 mg/L 3compartmentss NA 50% Human Human -DTXSID4044668 Css NA 29.15 mg/L 3compartmentss NA 95% Human Human -DTXSID4044668 Css NA 4.386 mg/L PBTK NA 50% Human Human -DTXSID4044668 Css NA 19.31 mg/L PBTK NA 95% Human Human -DTXSID4044668 Clint NA 2.453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044668 Fup NA 0.0702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044668 Vd NA 2.023 L/kg 1compartment NA NA Rat Human -DTXSID4044668 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID4044668 TK.Half.Life NA 25.13 hours 1compartment NA NA Rat Human -DTXSID4044668 Css NA 3.219 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044668 Css NA 10.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044668 Css NA 2.109 mg/L PBTK NA 50% Rat Human -DTXSID4044668 Css NA 6.463 mg/L PBTK NA 95% Rat Human +DTXSID4044664 TK.Half.Life NA 0.6856 hours 1compartment NA NA Rat Human +DTXSID4044664 Css NA 0.03185 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044664 Css NA 0.1439 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044664 Css NA 0.02131 mg/L PBTK NA 50% Rat Human +DTXSID4044664 Css NA 0.08878 mg/L PBTK NA 95% Rat Human DTXSID4044743 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4044743 Fup NA 0.2072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044743 Vd NA 0.3101 L/kg 1compartment NA NA Human Human +DTXSID4044743 Vd NA 0.3268 L/kg 1compartment NA NA Human Human DTXSID4044743 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4044743 TK.Half.Life NA 9.682 hours 1compartment NA NA Human Human -DTXSID4044743 Css NA 3.905 mg/L 3compartmentss NA 50% Human Human -DTXSID4044743 Css NA 13.96 mg/L 3compartmentss NA 95% Human Human -DTXSID4044743 Css NA 2.537 mg/L PBTK NA 50% Human Human -DTXSID4044743 Css NA 8.512 mg/L PBTK NA 95% Human Human +DTXSID4044743 TK.Half.Life NA 10.2 hours 1compartment NA NA Human Human +DTXSID4044743 Css NA 3.786 mg/L 3compartmentss NA 50% Human Human +DTXSID4044743 Css NA 13.74 mg/L 3compartmentss NA 95% Human Human +DTXSID4044743 Css NA 2.472 mg/L PBTK NA 50% Human Human +DTXSID4044743 Css NA 8.302 mg/L PBTK NA 95% Human Human DTXSID4044743 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4044743 Fup NA 0.2072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044743 Vd NA 0.318 L/kg 1compartment NA NA Rat Human +DTXSID4044743 Vd NA 0.3328 L/kg 1compartment NA NA Rat Human DTXSID4044743 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044743 TK.Half.Life NA 3.385 hours 1compartment NA NA Rat Human -DTXSID4044743 Css NA 1.097 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044743 Css NA 3.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044743 Css NA 0.6701 mg/L PBTK NA 50% Rat Human -DTXSID4044743 Css NA 1.823 mg/L PBTK NA 95% Rat Human -DTXSID4044745 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044745 Fup NA 0.7699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044745 Vd NA 1.403 L/kg 1compartment NA NA Human Human -DTXSID4044745 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4044745 TK.Half.Life NA 13.17 hours 1compartment NA NA Human Human -DTXSID4044745 Css NA 0.9705 mg/L 3compartmentss NA 50% Human Human -DTXSID4044745 Css NA 6.239 mg/L 3compartmentss NA 95% Human Human -DTXSID4044745 Css NA 0.8844 mg/L PBTK NA 50% Human Human -DTXSID4044745 Css NA 4.197 mg/L PBTK NA 95% Human Human -DTXSID4044745 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044745 Fup NA 0.7699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044745 Vd NA 1.263 L/kg 1compartment NA NA Rat Human -DTXSID4044745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044745 TK.Half.Life NA 3.717 hours 1compartment NA NA Rat Human -DTXSID4044745 Css NA 0.2517 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044745 Css NA 1.581 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044745 Css NA 0.2233 mg/L PBTK NA 50% Rat Human -DTXSID4044745 Css NA 0.9788 mg/L PBTK NA 95% Rat Human -DTXSID4044747 Clint NA 1.396 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044747 Fup NA 0.7377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044747 Vd NA 3.351 L/kg 1compartment NA NA Human Human -DTXSID4044747 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044747 TK.Half.Life NA 11.18 hours 1compartment NA NA Human Human -DTXSID4044747 Css NA 0.2513 mg/L 3compartmentss NA 50% Human Human -DTXSID4044747 Css NA 1.962 mg/L 3compartmentss NA 95% Human Human -DTXSID4044747 Css NA 0.2936 mg/L PBTK NA 50% Human Human -DTXSID4044747 Css NA 1.523 mg/L PBTK NA 95% Human Human -DTXSID4044747 Clint NA 1.396 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044747 Fup NA 0.7377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044747 Vd NA 3.255 L/kg 1compartment NA NA Rat Human -DTXSID4044747 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044747 TK.Half.Life NA 4.888 hours 1compartment NA NA Rat Human -DTXSID4044747 Css NA 0.0979 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044747 Css NA 0.7741 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044747 Css NA 0.1168 mg/L PBTK NA 50% Rat Human -DTXSID4044747 Css NA 0.5406 mg/L PBTK NA 95% Rat Human +DTXSID4044743 TK.Half.Life NA 3.542 hours 1compartment NA NA Rat Human +DTXSID4044743 Css NA 0.2444 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044743 Css NA 0.7229 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044743 Css NA 0.156 mg/L PBTK NA 50% Rat Human +DTXSID4044743 Css NA 0.4253 mg/L PBTK NA 95% Rat Human +DTXSID4044747 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044747 Fup 0.533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044747 Vd NA 2.765 L/kg 1compartment NA NA Human Human +DTXSID4044747 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4044747 TK.Half.Life NA 38.74 hours 1compartment NA NA Human Human +DTXSID4044747 Css NA 1.11 mg/L 3compartmentss NA 50% Human Human +DTXSID4044747 Css NA 7.32 mg/L 3compartmentss NA 95% Human Human +DTXSID4044747 Css NA 1.175 mg/L PBTK NA 50% Human Human +DTXSID4044747 Css NA 5.24 mg/L PBTK NA 95% Human Human +DTXSID4044747 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044747 Fup 0.533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044747 Vd NA 2.671 L/kg 1compartment NA NA Rat Human +DTXSID4044747 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4044747 TK.Half.Life NA 11.46 hours 1compartment NA NA Rat Human +DTXSID4044747 Css NA 0.06823 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044747 Css NA 0.4156 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044747 Css NA 0.07314 mg/L PBTK NA 50% Rat Human +DTXSID4044747 Css NA 0.2868 mg/L PBTK NA 95% Rat Human +DTXSID4044791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044791 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044791 Vd NA 1.877 L/kg 1compartment NA NA Human Human +DTXSID4044791 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044791 TK.Half.Life NA 4.575 hours 1compartment NA NA Human Human +DTXSID4044791 Css NA 0.2251 mg/L 3compartmentss NA 50% Human Human +DTXSID4044791 Css NA 1.659 mg/L 3compartmentss NA 95% Human Human +DTXSID4044791 Css NA 0.1556 mg/L PBTK NA 50% Human Human +DTXSID4044791 Css NA 1.085 mg/L PBTK NA 95% Human Human +DTXSID4044791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044791 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044791 Vd NA 1.438 L/kg 1compartment NA NA Rat Human +DTXSID4044791 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044791 TK.Half.Life NA 1.603 hours 1compartment NA NA Rat Human +DTXSID4044791 Css NA 0.02919 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044791 Css NA 0.1634 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044791 Css NA 0.01993 mg/L PBTK NA 50% Rat Human +DTXSID4044791 Css NA 0.1059 mg/L PBTK NA 95% Rat Human DTXSID4044793 Clint NA 1.091 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4044793 Fup NA 0.628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044793 Vd NA 0.4239 L/kg 1compartment NA NA Human Human +DTXSID4044793 Vd NA 0.3562 L/kg 1compartment NA NA Human Human DTXSID4044793 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044793 TK.Half.Life NA 1.646 hours 1compartment NA NA Human Human -DTXSID4044793 Css NA 0.4712 mg/L 3compartmentss NA 50% Human Human -DTXSID4044793 Css NA 3.217 mg/L 3compartmentss NA 95% Human Human -DTXSID4044793 Css NA 0.3402 mg/L PBTK NA 50% Human Human -DTXSID4044793 Css NA 1.995 mg/L PBTK NA 95% Human Human +DTXSID4044793 TK.Half.Life NA 0.4612 hours 1compartment NA NA Human Human +DTXSID4044793 Css NA 0.0715 mg/L 3compartmentss NA 50% Human Human +DTXSID4044793 Css NA 0.6955 mg/L 3compartmentss NA 95% Human Human +DTXSID4044793 Css NA 0.04974 mg/L PBTK NA 50% Human Human +DTXSID4044793 Css NA 0.4421 mg/L PBTK NA 95% Human Human DTXSID4044793 Clint NA 1.091 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4044793 Fup NA 0.628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044793 Vd NA 0.4392 L/kg 1compartment NA NA Rat Human +DTXSID4044793 Vd NA 0.382 L/kg 1compartment NA NA Rat Human DTXSID4044793 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044793 TK.Half.Life NA 0.8377 hours 1compartment NA NA Rat Human -DTXSID4044793 Css NA 0.1839 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044793 Css NA 1.162 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044793 Css NA 0.1277 mg/L PBTK NA 50% Rat Human -DTXSID4044793 Css NA 0.6662 mg/L PBTK NA 95% Rat Human -DTXSID4044799 Clint NA 8.727 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044799 Fup NA 0.2139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044799 Vd NA 2.62 L/kg 1compartment NA NA Human Human -DTXSID4044799 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4044799 TK.Half.Life NA 15.2 hours 1compartment NA NA Human Human -DTXSID4044799 Css NA 0.6034 mg/L 3compartmentss NA 50% Human Human -DTXSID4044799 Css NA 3.565 mg/L 3compartmentss NA 95% Human Human -DTXSID4044799 Css NA 0.4392 mg/L PBTK NA 50% Human Human -DTXSID4044799 Css NA 2.447 mg/L PBTK NA 95% Human Human -DTXSID4044799 Clint NA 8.727 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044799 Fup NA 0.2139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044799 Vd NA 1.993 L/kg 1compartment NA NA Rat Human -DTXSID4044799 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044799 TK.Half.Life NA 3.654 hours 1compartment NA NA Rat Human -DTXSID4044799 Css NA 0.325 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044799 Css NA 1.342 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044799 Css NA 0.2265 mg/L PBTK NA 50% Rat Human -DTXSID4044799 Css NA 0.8956 mg/L PBTK NA 95% Rat Human -DTXSID4044820 Clint NA 5.333 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044820 Fup NA 0.5244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044820 Vd NA 0.4278 L/kg 1compartment NA NA Human Human +DTXSID4044793 TK.Half.Life NA 0.2563 hours 1compartment NA NA Rat Human +DTXSID4044793 Css NA 0.00249 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044793 Css NA 0.02738 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044793 Css NA 0.001686 mg/L PBTK NA 50% Rat Human +DTXSID4044793 Css NA 0.01661 mg/L PBTK NA 95% Rat Human +DTXSID4044820 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044820 Fup 0.651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044820 Vd NA 0.5427 L/kg 1compartment NA NA Human Human DTXSID4044820 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044820 TK.Half.Life NA 0.7706 hours 1compartment NA NA Human Human -DTXSID4044820 Css NA 0.1524 mg/L 3compartmentss NA 50% Human Human -DTXSID4044820 Css NA 1.133 mg/L 3compartmentss NA 95% Human Human -DTXSID4044820 Css NA 0.1099 mg/L PBTK NA 50% Human Human -DTXSID4044820 Css NA 0.7261 mg/L PBTK NA 95% Human Human -DTXSID4044820 Clint NA 5.333 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044820 Fup NA 0.5244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044820 Vd NA 0.4406 L/kg 1compartment NA NA Rat Human +DTXSID4044820 TK.Half.Life NA 5.394 hours 1compartment NA NA Human Human +DTXSID4044820 Css NA 1.159 mg/L 3compartmentss NA 50% Human Human +DTXSID4044820 Css NA 7.534 mg/L 3compartmentss NA 95% Human Human +DTXSID4044820 Css NA 0.9 mg/L PBTK NA 50% Human Human +DTXSID4044820 Css NA 4.646 mg/L PBTK NA 95% Human Human +DTXSID4044820 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044820 Fup 0.651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044820 Vd NA 0.5523 L/kg 1compartment NA NA Rat Human DTXSID4044820 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044820 TK.Half.Life NA 0.4313 hours 1compartment NA NA Rat Human -DTXSID4044820 Css NA 0.07595 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044820 Css NA 0.4519 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044820 Css NA 0.05232 mg/L PBTK NA 50% Rat Human -DTXSID4044820 Css NA 0.2684 mg/L PBTK NA 95% Rat Human -DTXSID4044822 Clint NA 18.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044822 Fup NA 0.1109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044822 Vd NA 2.957 L/kg 1compartment NA NA Human Human -DTXSID4044822 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4044822 TK.Half.Life NA 26.38 hours 1compartment NA NA Human Human -DTXSID4044822 Css NA 1.052 mg/L 3compartmentss NA 50% Human Human -DTXSID4044822 Css NA 6.544 mg/L 3compartmentss NA 95% Human Human -DTXSID4044822 Css NA 0.735 mg/L PBTK NA 50% Human Human -DTXSID4044822 Css NA 4.463 mg/L PBTK NA 95% Human Human -DTXSID4044822 Clint NA 18.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044822 Fup NA 0.1109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044822 Vd NA 2.224 L/kg 1compartment NA NA Rat Human -DTXSID4044822 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4044822 TK.Half.Life NA 4.702 hours 1compartment NA NA Rat Human -DTXSID4044822 Css NA 0.58 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044822 Css NA 2.818 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044822 Css NA 0.3877 mg/L PBTK NA 50% Rat Human -DTXSID4044822 Css NA 1.808 mg/L PBTK NA 95% Rat Human -DTXSID4044824 Clint NA 1.907 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044824 Fup NA 0.2736 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044824 Vd NA 2.781 L/kg 1compartment NA NA Human Human -DTXSID4044824 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID4044824 TK.Half.Life NA 58.05 hours 1compartment NA NA Human Human -DTXSID4044824 Css NA 2.387 mg/L 3compartmentss NA 50% Human Human -DTXSID4044824 Css NA 9.577 mg/L 3compartmentss NA 95% Human Human -DTXSID4044824 Css NA 1.752 mg/L PBTK NA 50% Human Human -DTXSID4044824 Css NA 6.733 mg/L PBTK NA 95% Human Human -DTXSID4044824 Clint NA 1.907 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044824 Fup NA 0.2736 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044824 Vd NA 2.115 L/kg 1compartment NA NA Rat Human -DTXSID4044824 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4044824 TK.Half.Life NA 10.5 hours 1compartment NA NA Rat Human -DTXSID4044824 Css NA 1.104 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044824 Css NA 3.085 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044824 Css NA 0.7806 mg/L PBTK NA 50% Rat Human -DTXSID4044824 Css NA 1.995 mg/L PBTK NA 95% Rat Human -DTXSID4044870 Clint NA 0.7819 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044870 Fup NA 0.2652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044870 Vd NA 1.717 L/kg 1compartment NA NA Human Human -DTXSID4044870 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4044870 TK.Half.Life NA 25.15 hours 1compartment NA NA Human Human -DTXSID4044870 Css NA 1.592 mg/L 3compartmentss NA 50% Human Human -DTXSID4044870 Css NA 6.168 mg/L 3compartmentss NA 95% Human Human -DTXSID4044870 Css NA 1.198 mg/L PBTK NA 50% Human Human -DTXSID4044870 Css NA 4.038 mg/L PBTK NA 95% Human Human -DTXSID4044870 Clint NA 0.7819 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044870 Fup NA 0.2652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044870 Vd NA 1.358 L/kg 1compartment NA NA Rat Human -DTXSID4044870 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4044870 TK.Half.Life NA 7.406 hours 1compartment NA NA Rat Human -DTXSID4044870 Css NA 0.6232 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044870 Css NA 1.919 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044870 Css NA 0.4512 mg/L PBTK NA 50% Rat Human -DTXSID4044870 Css NA 1.187 mg/L PBTK NA 95% Rat Human -DTXSID4044872 Clint NA 9.309 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044872 Fup NA 0.047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044872 Vd NA 1.929 L/kg 1compartment NA NA Human Human -DTXSID4044872 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4044872 TK.Half.Life NA 22.16 hours 1compartment NA NA Human Human -DTXSID4044872 Css NA 1.692 mg/L 3compartmentss NA 50% Human Human -DTXSID4044872 Css NA 11.37 mg/L 3compartmentss NA 95% Human Human -DTXSID4044872 Css NA 1.106 mg/L PBTK NA 50% Human Human -DTXSID4044872 Css NA 7.123 mg/L PBTK NA 95% Human Human -DTXSID4044872 Clint NA 9.309 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044872 Fup NA 0.047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044872 Vd NA 1.444 L/kg 1compartment NA NA Rat Human -DTXSID4044872 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4044872 TK.Half.Life NA 7.263 hours 1compartment NA NA Rat Human -DTXSID4044872 Css NA 0.9196 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044872 Css NA 4.565 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044872 Css NA 0.5682 mg/L PBTK NA 50% Rat Human -DTXSID4044872 Css NA 2.672 mg/L PBTK NA 95% Rat Human -DTXSID4044874 Clint NA 6306 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044874 Fup NA 0.0663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044874 Vd NA 1.988 L/kg 1compartment NA NA Human Human -DTXSID4044874 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044874 TK.Half.Life NA 1.701 hours 1compartment NA NA Human Human -DTXSID4044874 Css NA 0.001934 mg/L 3compartmentss NA 50% Human Human -DTXSID4044874 Css NA 0.01465 mg/L 3compartmentss NA 95% Human Human -DTXSID4044874 Css NA 0.001289 mg/L PBTK NA 50% Human Human -DTXSID4044874 Css NA 0.009238 mg/L PBTK NA 95% Human Human -DTXSID4044874 Clint NA 6306 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044874 Fup NA 0.0663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044874 Vd NA 1.496 L/kg 1compartment NA NA Rat Human -DTXSID4044874 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044874 TK.Half.Life NA 0.5594 hours 1compartment NA NA Rat Human -DTXSID4044874 Css NA 0.001119 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044874 Css NA 0.006653 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044874 Css NA 0.0007014 mg/L PBTK NA 50% Rat Human -DTXSID4044874 Css NA 0.004095 mg/L PBTK NA 95% Rat Human -DTXSID4044876 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044876 Fup NA 0.867 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044876 Vd NA 0.8514 L/kg 1compartment NA NA Human Human +DTXSID4044820 TK.Half.Life NA 1.87 hours 1compartment NA NA Rat Human +DTXSID4044820 Css NA 0.07023 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044820 Css NA 0.4061 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044820 Css NA 0.05418 mg/L PBTK NA 50% Rat Human +DTXSID4044820 Css NA 0.2455 mg/L PBTK NA 95% Rat Human +DTXSID4044822 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044822 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044822 Vd NA 1.665 L/kg 1compartment NA NA Human Human +DTXSID4044822 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044822 TK.Half.Life NA 4.089 hours 1compartment NA NA Human Human +DTXSID4044822 Css NA 0.2382 mg/L 3compartmentss NA 50% Human Human +DTXSID4044822 Css NA 1.805 mg/L 3compartmentss NA 95% Human Human +DTXSID4044822 Css NA 0.1626 mg/L PBTK NA 50% Human Human +DTXSID4044822 Css NA 1.164 mg/L PBTK NA 95% Human Human +DTXSID4044822 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044822 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044822 Vd NA 1.284 L/kg 1compartment NA NA Rat Human +DTXSID4044822 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044822 TK.Half.Life NA 1.533 hours 1compartment NA NA Rat Human +DTXSID4044822 Css NA 0.03048 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044822 Css NA 0.1802 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044822 Css NA 0.02044 mg/L PBTK NA 50% Rat Human +DTXSID4044822 Css NA 0.1123 mg/L PBTK NA 95% Rat Human +DTXSID4044870 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044870 Fup 0.334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044870 Vd NA 2.743 L/kg 1compartment NA NA Human Human +DTXSID4044870 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044870 TK.Half.Life NA 6.454 hours 1compartment NA NA Human Human +DTXSID4044870 Css NA 0.1856 mg/L 3compartmentss NA 50% Human Human +DTXSID4044870 Css NA 1.192 mg/L 3compartmentss NA 95% Human Human +DTXSID4044870 Css NA 0.1385 mg/L PBTK NA 50% Human Human +DTXSID4044870 Css NA 0.8473 mg/L PBTK NA 95% Human Human +DTXSID4044870 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044870 Fup 0.334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044870 Vd NA 2.097 L/kg 1compartment NA NA Rat Human +DTXSID4044870 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044870 TK.Half.Life NA 1.623 hours 1compartment NA NA Rat Human +DTXSID4044870 Css NA 0.02348 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044870 Css NA 0.1154 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044870 Css NA 0.01758 mg/L PBTK NA 50% Rat Human +DTXSID4044870 Css NA 0.08217 mg/L PBTK NA 95% Rat Human +DTXSID4044872 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044872 Fup 0.0513 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044872 Vd NA 1.653 L/kg 1compartment NA NA Human Human +DTXSID4044872 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044872 TK.Half.Life NA 7.896 hours 1compartment NA NA Human Human +DTXSID4044872 Css NA 0.6243 mg/L 3compartmentss NA 50% Human Human +DTXSID4044872 Css NA 4.865 mg/L 3compartmentss NA 95% Human Human +DTXSID4044872 Css NA 0.403 mg/L PBTK NA 50% Human Human +DTXSID4044872 Css NA 2.991 mg/L PBTK NA 95% Human Human +DTXSID4044872 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044872 Fup 0.0513 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044872 Vd NA 1.242 L/kg 1compartment NA NA Rat Human +DTXSID4044872 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044872 TK.Half.Life NA 2.914 hours 1compartment NA NA Rat Human +DTXSID4044872 Css NA 0.08164 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044872 Css NA 0.4935 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044872 Css NA 0.05137 mg/L PBTK NA 50% Rat Human +DTXSID4044872 Css NA 0.2968 mg/L PBTK NA 95% Rat Human +DTXSID4044874 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044874 Fup 0.0411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044874 Vd NA 3.113 L/kg 1compartment NA NA Human Human +DTXSID4044874 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID4044874 TK.Half.Life NA 77.39 hours 1compartment NA NA Human Human +DTXSID4044874 Css NA 2.907 mg/L 3compartmentss NA 50% Human Human +DTXSID4044874 Css NA 20.13 mg/L 3compartmentss NA 95% Human Human +DTXSID4044874 Css NA 2.028 mg/L PBTK NA 50% Human Human +DTXSID4044874 Css NA 13.67 mg/L PBTK NA 95% Human Human +DTXSID4044874 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044874 Fup 0.0411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044874 Vd NA 2.332 L/kg 1compartment NA NA Rat Human +DTXSID4044874 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID4044874 TK.Half.Life NA 10.59 hours 1compartment NA NA Rat Human +DTXSID4044874 Css NA 0.3764 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044874 Css NA 2.193 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044874 Css NA 0.2578 mg/L PBTK NA 50% Rat Human +DTXSID4044874 Css NA 1.441 mg/L PBTK NA 95% Rat Human +DTXSID4044876 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044876 Fup 0.658 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044876 Vd NA 0.6441 L/kg 1compartment NA NA Human Human DTXSID4044876 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044876 TK.Half.Life NA 6.388 hours 1compartment NA NA Human Human -DTXSID4044876 Css NA 0.9214 mg/L 3compartmentss NA 50% Human Human -DTXSID4044876 Css NA 5.48 mg/L 3compartmentss NA 95% Human Human -DTXSID4044876 Css NA 0.7808 mg/L PBTK NA 50% Human Human -DTXSID4044876 Css NA 3.606 mg/L PBTK NA 95% Human Human -DTXSID4044876 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044876 Fup NA 0.867 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044876 Vd NA 0.8647 L/kg 1compartment NA NA Rat Human +DTXSID4044876 TK.Half.Life NA 6.342 hours 1compartment NA NA Human Human +DTXSID4044876 Css NA 1.124 mg/L 3compartmentss NA 50% Human Human +DTXSID4044876 Css NA 7.335 mg/L 3compartmentss NA 95% Human Human +DTXSID4044876 Css NA 0.8942 mg/L PBTK NA 50% Human Human +DTXSID4044876 Css NA 4.579 mg/L PBTK NA 95% Human Human +DTXSID4044876 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044876 Fup 0.658 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044876 Vd NA 0.6669 L/kg 1compartment NA NA Rat Human DTXSID4044876 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044876 TK.Half.Life NA 2.202 hours 1compartment NA NA Rat Human -DTXSID4044876 Css NA 0.2351 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044876 Css NA 1.368 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044876 Css NA 0.1943 mg/L PBTK NA 50% Rat Human -DTXSID4044876 Css NA 0.8306 mg/L PBTK NA 95% Rat Human -DTXSID4044901 Clint NA 5.695 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044901 Fup NA 0.0714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044901 Vd NA 1.807 L/kg 1compartment NA NA Human Human -DTXSID4044901 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4044901 TK.Half.Life NA 21.6 hours 1compartment NA NA Human Human -DTXSID4044901 Css NA 1.608 mg/L 3compartmentss NA 50% Human Human -DTXSID4044901 Css NA 9.156 mg/L 3compartmentss NA 95% Human Human -DTXSID4044901 Css NA 1.068 mg/L PBTK NA 50% Human Human -DTXSID4044901 Css NA 5.848 mg/L PBTK NA 95% Human Human -DTXSID4044901 Clint NA 5.695 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044901 Fup NA 0.0714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044901 Vd NA 1.363 L/kg 1compartment NA NA Rat Human -DTXSID4044901 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4044901 TK.Half.Life NA 7.324 hours 1compartment NA NA Rat Human -DTXSID4044901 Css NA 0.8606 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044901 Css NA 3.421 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044901 Css NA 0.5396 mg/L PBTK NA 50% Rat Human -DTXSID4044901 Css NA 2.046 mg/L PBTK NA 95% Rat Human -DTXSID4044903 Clint NA 1535 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044903 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044903 Vd NA 3.041 L/kg 1compartment NA NA Human Human -DTXSID4044903 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044903 TK.Half.Life NA 3.408 hours 1compartment NA NA Human Human -DTXSID4044903 Css NA 0.0391 mg/L 3compartmentss NA 50% Human Human -DTXSID4044903 Css NA 0.2504 mg/L 3compartmentss NA 95% Human Human -DTXSID4044903 Css NA 0.02684 mg/L PBTK NA 50% Human Human -DTXSID4044903 Css NA 0.169 mg/L PBTK NA 95% Human Human -DTXSID4044903 Clint NA 1535 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044903 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044903 Vd NA 2.277 L/kg 1compartment NA NA Rat Human -DTXSID4044903 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044903 TK.Half.Life NA 0.9525 hours 1compartment NA NA Rat Human -DTXSID4044903 Css NA 0.02203 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044903 Css NA 0.1189 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044903 Css NA 0.01442 mg/L PBTK NA 50% Rat Human -DTXSID4044903 Css NA 0.07654 mg/L PBTK NA 95% Rat Human -DTXSID4044905 Clint NA 13.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044905 Fup NA 0.7369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044905 Vd NA 0.8164 L/kg 1compartment NA NA Human Human +DTXSID4044876 TK.Half.Life NA 2.235 hours 1compartment NA NA Rat Human +DTXSID4044876 Css NA 0.06796 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044876 Css NA 0.4196 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044876 Css NA 0.05375 mg/L PBTK NA 50% Rat Human +DTXSID4044876 Css NA 0.2553 mg/L PBTK NA 95% Rat Human +DTXSID4044878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044878 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044878 Vd NA 2.126 L/kg 1compartment NA NA Human Human +DTXSID4044878 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044878 TK.Half.Life NA 5.894 hours 1compartment NA NA Human Human +DTXSID4044878 Css NA 0.2736 mg/L 3compartmentss NA 50% Human Human +DTXSID4044878 Css NA 1.877 mg/L 3compartmentss NA 95% Human Human +DTXSID4044878 Css NA 0.1898 mg/L PBTK NA 50% Human Human +DTXSID4044878 Css NA 1.257 mg/L PBTK NA 95% Human Human +DTXSID4044878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044878 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044878 Vd NA 1.619 L/kg 1compartment NA NA Rat Human +DTXSID4044878 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044878 TK.Half.Life NA 1.891 hours 1compartment NA NA Rat Human +DTXSID4044878 Css NA 0.0345 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044878 Css NA 0.1927 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044878 Css NA 0.02374 mg/L PBTK NA 50% Rat Human +DTXSID4044878 Css NA 0.1259 mg/L PBTK NA 95% Rat Human +DTXSID4044901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044901 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044901 Vd NA 2.506 L/kg 1compartment NA NA Human Human +DTXSID4044901 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4044901 TK.Half.Life NA 8.854 hours 1compartment NA NA Human Human +DTXSID4044901 Css NA 0.3595 mg/L 3compartmentss NA 50% Human Human +DTXSID4044901 Css NA 2.466 mg/L 3compartmentss NA 95% Human Human +DTXSID4044901 Css NA 0.2526 mg/L PBTK NA 50% Human Human +DTXSID4044901 Css NA 1.634 mg/L PBTK NA 95% Human Human +DTXSID4044901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044901 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044901 Vd NA 1.897 L/kg 1compartment NA NA Rat Human +DTXSID4044901 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4044901 TK.Half.Life NA 2.367 hours 1compartment NA NA Rat Human +DTXSID4044901 Css NA 0.0458 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044901 Css NA 0.2476 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044901 Css NA 0.03189 mg/L PBTK NA 50% Rat Human +DTXSID4044901 Css NA 0.162 mg/L PBTK NA 95% Rat Human +DTXSID4044905 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044905 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044905 Vd NA 0.7054 L/kg 1compartment NA NA Human Human DTXSID4044905 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044905 TK.Half.Life NA 0.7527 hours 1compartment NA NA Human Human -DTXSID4044905 Css NA 0.04684 mg/L 3compartmentss NA 50% Human Human -DTXSID4044905 Css NA 0.4224 mg/L 3compartmentss NA 95% Human Human -DTXSID4044905 Css NA 0.03868 mg/L PBTK NA 50% Human Human -DTXSID4044905 Css NA 0.2952 mg/L PBTK NA 95% Human Human -DTXSID4044905 Clint NA 13.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044905 Fup NA 0.7369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044905 Vd NA 0.8209 L/kg 1compartment NA NA Rat Human +DTXSID4044905 TK.Half.Life NA 7.845 hours 1compartment NA NA Human Human +DTXSID4044905 Css NA 1.248 mg/L 3compartmentss NA 50% Human Human +DTXSID4044905 Css NA 8.389 mg/L 3compartmentss NA 95% Human Human +DTXSID4044905 Css NA 0.9896 mg/L PBTK NA 50% Human Human +DTXSID4044905 Css NA 5.287 mg/L PBTK NA 95% Human Human +DTXSID4044905 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044905 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044905 Vd NA 0.7085 L/kg 1compartment NA NA Rat Human DTXSID4044905 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044905 TK.Half.Life NA 0.3823 hours 1compartment NA NA Rat Human -DTXSID4044905 Css NA 0.02344 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044905 Css NA 0.1878 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044905 Css NA 0.01885 mg/L PBTK NA 50% Rat Human -DTXSID4044905 Css NA 0.122 mg/L PBTK NA 95% Rat Human -DTXSID4044951 Clint NA 0.02172 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044951 Fup NA 0.6643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044951 Vd NA 0.6094 L/kg 1compartment NA NA Human Human -DTXSID4044951 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044951 TK.Half.Life NA 5.682 hours 1compartment NA NA Human Human -DTXSID4044951 Css NA 1.084 mg/L 3compartmentss NA 50% Human Human -DTXSID4044951 Css NA 7.198 mg/L 3compartmentss NA 95% Human Human -DTXSID4044951 Css NA 0.8579 mg/L PBTK NA 50% Human Human -DTXSID4044951 Css NA 4.496 mg/L PBTK NA 95% Human Human -DTXSID4044951 Clint NA 0.02172 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044951 Fup NA 0.6643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044951 Vd NA 0.6391 L/kg 1compartment NA NA Rat Human -DTXSID4044951 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044951 TK.Half.Life NA 2.077 hours 1compartment NA NA Rat Human -DTXSID4044951 Css NA 0.2941 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044951 Css NA 1.908 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044951 Css NA 0.2236 mg/L PBTK NA 50% Rat Human -DTXSID4044951 Css NA 1.114 mg/L PBTK NA 95% Rat Human -DTXSID4044953 Clint NA 2.613 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044953 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044953 Vd NA 1.009 L/kg 1compartment NA NA Human Human +DTXSID4044905 TK.Half.Life NA 2.673 hours 1compartment NA NA Rat Human +DTXSID4044905 Css NA 0.07503 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044905 Css NA 0.4756 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044905 Css NA 0.0594 mg/L PBTK NA 50% Rat Human +DTXSID4044905 Css NA 0.2887 mg/L PBTK NA 95% Rat Human +DTXSID4044953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044953 Fup 0.581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044953 Vd NA 0.7244 L/kg 1compartment NA NA Human Human DTXSID4044953 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044953 TK.Half.Life NA 1.591 hours 1compartment NA NA Human Human -DTXSID4044953 Css NA 0.1546 mg/L 3compartmentss NA 50% Human Human -DTXSID4044953 Css NA 1.205 mg/L 3compartmentss NA 95% Human Human -DTXSID4044953 Css NA 0.1354 mg/L PBTK NA 50% Human Human -DTXSID4044953 Css NA 0.869 mg/L PBTK NA 95% Human Human -DTXSID4044953 Clint NA 2.613 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044953 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044953 Vd NA 1.017 L/kg 1compartment NA NA Rat Human +DTXSID4044953 TK.Half.Life NA 0.6691 hours 1compartment NA NA Human Human +DTXSID4044953 Css NA 0.03448 mg/L 3compartmentss NA 50% Human Human +DTXSID4044953 Css NA 0.3754 mg/L 3compartmentss NA 95% Human Human +DTXSID4044953 Css NA 0.02693 mg/L PBTK NA 50% Human Human +DTXSID4044953 Css NA 0.2507 mg/L PBTK NA 95% Human Human +DTXSID4044953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044953 Fup 0.581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044953 Vd NA 0.728 L/kg 1compartment NA NA Rat Human DTXSID4044953 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044953 TK.Half.Life NA 0.833 hours 1compartment NA NA Rat Human -DTXSID4044953 Css NA 0.06612 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044953 Css NA 0.4743 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044953 Css NA 0.05766 mg/L PBTK NA 50% Rat Human -DTXSID4044953 Css NA 0.2953 mg/L PBTK NA 95% Rat Human -DTXSID4044955 Clint NA 0.006756 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044955 Fup NA 0.416 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4044955 Vd NA 0.3906 L/kg 1compartment NA NA Human Human +DTXSID4044953 TK.Half.Life NA 0.3347 hours 1compartment NA NA Rat Human +DTXSID4044953 Css NA 0.004172 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044953 Css NA 0.03908 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044953 Css NA 0.003319 mg/L PBTK NA 50% Rat Human +DTXSID4044953 Css NA 0.02589 mg/L PBTK NA 95% Rat Human +DTXSID4044955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044955 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4044955 Vd NA 0.454 L/kg 1compartment NA NA Human Human DTXSID4044955 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4044955 TK.Half.Life NA 6.006 hours 1compartment NA NA Human Human -DTXSID4044955 Css NA 1.812 mg/L 3compartmentss NA 50% Human Human -DTXSID4044955 Css NA 7.909 mg/L 3compartmentss NA 95% Human Human -DTXSID4044955 Css NA 1.273 mg/L PBTK NA 50% Human Human -DTXSID4044955 Css NA 4.837 mg/L PBTK NA 95% Human Human -DTXSID4044955 Clint NA 0.006756 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044955 Fup NA 0.416 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4044955 Vd NA 0.3988 L/kg 1compartment NA NA Rat Human +DTXSID4044955 TK.Half.Life NA 0.4252 hours 1compartment NA NA Human Human +DTXSID4044955 Css NA 0.0337 mg/L 3compartmentss NA 50% Human Human +DTXSID4044955 Css NA 0.3519 mg/L 3compartmentss NA 95% Human Human +DTXSID4044955 Css NA 0.02466 mg/L PBTK NA 50% Human Human +DTXSID4044955 Css NA 0.2269 mg/L PBTK NA 95% Human Human +DTXSID4044955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044955 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4044955 Vd NA 0.4685 L/kg 1compartment NA NA Rat Human DTXSID4044955 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4044955 TK.Half.Life NA 2.102 hours 1compartment NA NA Rat Human -DTXSID4044955 Css NA 0.5066 mg/L 3compartmentss NA 50% Rat Human -DTXSID4044955 Css NA 1.915 mg/L 3compartmentss NA 95% Rat Human -DTXSID4044955 Css NA 0.3367 mg/L PBTK NA 50% Rat Human -DTXSID4044955 Css NA 1.107 mg/L PBTK NA 95% Rat Human -DTXSID4045002 Clint NA 54.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045002 Fup NA 0.1111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045002 Vd NA 1.665 L/kg 1compartment NA NA Human Human +DTXSID4044955 TK.Half.Life NA 0.2139 hours 1compartment NA NA Rat Human +DTXSID4044955 Css NA 0.003973 mg/L 3compartmentss NA 50% Rat Human +DTXSID4044955 Css NA 0.03554 mg/L 3compartmentss NA 95% Rat Human +DTXSID4044955 Css NA 0.002924 mg/L PBTK NA 50% Rat Human +DTXSID4044955 Css NA 0.02259 mg/L PBTK NA 95% Rat Human +DTXSID4045002 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045002 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045002 Vd NA 1.446 L/kg 1compartment NA NA Human Human DTXSID4045002 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045002 TK.Half.Life NA 2.658 hours 1compartment NA NA Human Human -DTXSID4045002 Css NA 0.1198 mg/L 3compartmentss NA 50% Human Human -DTXSID4045002 Css NA 0.9215 mg/L 3compartmentss NA 95% Human Human -DTXSID4045002 Css NA 0.08037 mg/L PBTK NA 50% Human Human -DTXSID4045002 Css NA 0.5853 mg/L PBTK NA 95% Human Human -DTXSID4045002 Clint NA 54.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045002 Fup NA 0.1111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045002 Vd NA 1.272 L/kg 1compartment NA NA Rat Human +DTXSID4045002 TK.Half.Life NA 5.94 hours 1compartment NA NA Human Human +DTXSID4045002 Css NA 0.4042 mg/L 3compartmentss NA 50% Human Human +DTXSID4045002 Css NA 2.335 mg/L 3compartmentss NA 95% Human Human +DTXSID4045002 Css NA 0.2908 mg/L PBTK NA 50% Human Human +DTXSID4045002 Css NA 1.569 mg/L PBTK NA 95% Human Human +DTXSID4045002 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045002 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045002 Vd NA 1.142 L/kg 1compartment NA NA Rat Human DTXSID4045002 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045002 TK.Half.Life NA 0.9612 hours 1compartment NA NA Rat Human -DTXSID4045002 Css NA 0.06668 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045002 Css NA 0.4084 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045002 Css NA 0.04273 mg/L PBTK NA 50% Rat Human -DTXSID4045002 Css NA 0.2504 mg/L PBTK NA 95% Rat Human -DTXSID4045131 Clint NA 122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045131 Fup NA 0.3894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045131 Vd NA 2.661 L/kg 1compartment NA NA Human Human +DTXSID4045002 TK.Half.Life NA 2.379 hours 1compartment NA NA Rat Human +DTXSID4045002 Css NA 0.0486 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045002 Css NA 0.1993 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045002 Css NA 0.03453 mg/L PBTK NA 50% Rat Human +DTXSID4045002 Css NA 0.1289 mg/L PBTK NA 95% Rat Human +DTXSID4045131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045131 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045131 Vd NA 2.429 L/kg 1compartment NA NA Human Human DTXSID4045131 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045131 TK.Half.Life NA 1.598 hours 1compartment NA NA Human Human -DTXSID4045131 Css NA 0.007326 mg/L 3compartmentss NA 50% Human Human -DTXSID4045131 Css NA 0.06531 mg/L 3compartmentss NA 95% Human Human -DTXSID4045131 Css NA 0.007444 mg/L PBTK NA 50% Human Human -DTXSID4045131 Css NA 0.05447 mg/L PBTK NA 95% Human Human -DTXSID4045131 Clint NA 122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045131 Fup NA 0.3894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045131 Vd NA 2.628 L/kg 1compartment NA NA Rat Human +DTXSID4045131 TK.Half.Life NA 2.371 hours 1compartment NA NA Human Human +DTXSID4045131 Css NA 0.03976 mg/L 3compartmentss NA 50% Human Human +DTXSID4045131 Css NA 0.3419 mg/L 3compartmentss NA 95% Human Human +DTXSID4045131 Css NA 0.03849 mg/L PBTK NA 50% Human Human +DTXSID4045131 Css NA 0.2727 mg/L PBTK NA 95% Human Human +DTXSID4045131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045131 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045131 Vd NA 2.41 L/kg 1compartment NA NA Rat Human DTXSID4045131 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045131 TK.Half.Life NA 0.7289 hours 1compartment NA NA Rat Human -DTXSID4045131 Css NA 0.003855 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045131 Css NA 0.02953 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045131 Css NA 0.003892 mg/L PBTK NA 50% Rat Human -DTXSID4045131 Css NA 0.02403 mg/L PBTK NA 95% Rat Human -DTXSID4045133 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045133 Fup NA 0.2617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045133 Vd NA 0.5076 L/kg 1compartment NA NA Human Human -DTXSID4045133 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4045133 TK.Half.Life NA 12.62 hours 1compartment NA NA Human Human -DTXSID4045133 Css NA 2.941 mg/L 3compartmentss NA 50% Human Human -DTXSID4045133 Css NA 11.48 mg/L 3compartmentss NA 95% Human Human -DTXSID4045133 Css NA 2.03 mg/L PBTK NA 50% Human Human -DTXSID4045133 Css NA 7.103 mg/L PBTK NA 95% Human Human -DTXSID4045133 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045133 Fup NA 0.2617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045133 Vd NA 0.4939 L/kg 1compartment NA NA Rat Human +DTXSID4045131 TK.Half.Life NA 1.242 hours 1compartment NA NA Rat Human +DTXSID4045131 Css NA 0.004792 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045131 Css NA 0.0316 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045131 Css NA 0.004835 mg/L PBTK NA 50% Rat Human +DTXSID4045131 Css NA 0.02594 mg/L PBTK NA 95% Rat Human +DTXSID4045133 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045133 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045133 Vd NA 0.4871 L/kg 1compartment NA NA Human Human +DTXSID4045133 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4045133 TK.Half.Life NA 1.476 hours 1compartment NA NA Human Human +DTXSID4045133 Css NA 0.285 mg/L 3compartmentss NA 50% Human Human +DTXSID4045133 Css NA 1.744 mg/L 3compartmentss NA 95% Human Human +DTXSID4045133 Css NA 0.195 mg/L PBTK NA 50% Human Human +DTXSID4045133 Css NA 1.111 mg/L PBTK NA 95% Human Human +DTXSID4045133 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045133 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045133 Vd NA 0.4739 L/kg 1compartment NA NA Rat Human DTXSID4045133 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045133 TK.Half.Life NA 4.168 hours 1compartment NA NA Rat Human -DTXSID4045133 Css NA 0.8157 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045133 Css NA 2.597 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045133 Css NA 0.5349 mg/L PBTK NA 50% Rat Human -DTXSID4045133 Css NA 1.509 mg/L PBTK NA 95% Rat Human -DTXSID4045139 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045139 Fup NA 0.8558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045139 Vd NA 0.7648 L/kg 1compartment NA NA Human Human +DTXSID4045133 TK.Half.Life NA 0.831 hours 1compartment NA NA Rat Human +DTXSID4045133 Css NA 0.03447 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045133 Css NA 0.1493 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045133 Css NA 0.02314 mg/L PBTK NA 50% Rat Human +DTXSID4045133 Css NA 0.09215 mg/L PBTK NA 95% Rat Human +DTXSID4045139 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045139 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045139 Vd NA 0.4322 L/kg 1compartment NA NA Human Human DTXSID4045139 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045139 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human -DTXSID4045139 Css NA 0.9448 mg/L 3compartmentss NA 50% Human Human -DTXSID4045139 Css NA 5.834 mg/L 3compartmentss NA 95% Human Human -DTXSID4045139 Css NA 0.7829 mg/L PBTK NA 50% Human Human -DTXSID4045139 Css NA 3.775 mg/L PBTK NA 95% Human Human -DTXSID4045139 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045139 Fup NA 0.8558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045139 Vd NA 0.7887 L/kg 1compartment NA NA Rat Human +DTXSID4045139 TK.Half.Life NA 6.691 hours 1compartment NA NA Human Human +DTXSID4045139 Css NA 1.732 mg/L 3compartmentss NA 50% Human Human +DTXSID4045139 Css NA 7.533 mg/L 3compartmentss NA 95% Human Human +DTXSID4045139 Css NA 1.246 mg/L PBTK NA 50% Human Human +DTXSID4045139 Css NA 4.722 mg/L PBTK NA 95% Human Human +DTXSID4045139 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045139 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045139 Vd NA 0.4488 L/kg 1compartment NA NA Rat Human DTXSID4045139 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045139 TK.Half.Life NA 2.033 hours 1compartment NA NA Rat Human -DTXSID4045139 Css NA 0.2424 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045139 Css NA 1.419 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045139 Css NA 0.1953 mg/L PBTK NA 50% Rat Human -DTXSID4045139 Css NA 0.8524 mg/L PBTK NA 95% Rat Human -DTXSID4045181 Clint NA 60.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045181 Fup NA 0.0295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045181 Vd NA 2.73 L/kg 1compartment NA NA Human Human -DTXSID4045181 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045181 TK.Half.Life NA 13.29 hours 1compartment NA NA Human Human -DTXSID4045181 Css NA 0.5843 mg/L 3compartmentss NA 50% Human Human -DTXSID4045181 Css NA 3.997 mg/L 3compartmentss NA 95% Human Human -DTXSID4045181 Css NA 0.3942 mg/L PBTK NA 50% Human Human -DTXSID4045181 Css NA 2.575 mg/L PBTK NA 95% Human Human -DTXSID4045181 Clint NA 60.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045181 Fup NA 0.0295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045181 Vd NA 2.042 L/kg 1compartment NA NA Rat Human -DTXSID4045181 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045181 TK.Half.Life NA 2.977 hours 1compartment NA NA Rat Human -DTXSID4045181 Css NA 0.326 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045181 Css NA 1.877 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045181 Css NA 0.2085 mg/L PBTK NA 50% Rat Human -DTXSID4045181 Css NA 1.148 mg/L PBTK NA 95% Rat Human -DTXSID4045183 Clint NA 3.339 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045183 Fup NA 0.1882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045183 Vd NA 1.016 L/kg 1compartment NA NA Human Human +DTXSID4045139 TK.Half.Life NA 2.367 hours 1compartment NA NA Rat Human +DTXSID4045139 Css NA 0.1116 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045139 Css NA 0.4152 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045139 Css NA 0.07863 mg/L PBTK NA 50% Rat Human +DTXSID4045139 Css NA 0.2512 mg/L PBTK NA 95% Rat Human +DTXSID4045181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045181 Fup 0.0286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045181 Vd NA 2.894 L/kg 1compartment NA NA Human Human +DTXSID4045181 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4045181 TK.Half.Life NA 42.79 hours 1compartment NA NA Human Human +DTXSID4045181 Css NA 1.862 mg/L 3compartmentss NA 50% Human Human +DTXSID4045181 Css NA 12.62 mg/L 3compartmentss NA 95% Human Human +DTXSID4045181 Css NA 1.267 mg/L PBTK NA 50% Human Human +DTXSID4045181 Css NA 8.285 mg/L PBTK NA 95% Human Human +DTXSID4045181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045181 Fup 0.0286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045181 Vd NA 2.167 L/kg 1compartment NA NA Rat Human +DTXSID4045181 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4045181 TK.Half.Life NA 7.714 hours 1compartment NA NA Rat Human +DTXSID4045181 Css NA 0.2408 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045181 Css NA 1.369 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045181 Css NA 0.1624 mg/L PBTK NA 50% Rat Human +DTXSID4045181 Css NA 0.8997 mg/L PBTK NA 95% Rat Human +DTXSID4045183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045183 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045183 Vd NA 1.444 L/kg 1compartment NA NA Human Human DTXSID4045183 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045183 TK.Half.Life NA 6.256 hours 1compartment NA NA Human Human -DTXSID4045183 Css NA 0.6828 mg/L 3compartmentss NA 50% Human Human -DTXSID4045183 Css NA 3.526 mg/L 3compartmentss NA 95% Human Human -DTXSID4045183 Css NA 0.4778 mg/L PBTK NA 50% Human Human -DTXSID4045183 Css NA 2.285 mg/L PBTK NA 95% Human Human -DTXSID4045183 Clint NA 3.339 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045183 Fup NA 0.1882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045183 Vd NA 0.8332 L/kg 1compartment NA NA Rat Human +DTXSID4045183 TK.Half.Life NA 2.439 hours 1compartment NA NA Human Human +DTXSID4045183 Css NA 0.1116 mg/L 3compartmentss NA 50% Human Human +DTXSID4045183 Css NA 0.7743 mg/L 3compartmentss NA 95% Human Human +DTXSID4045183 Css NA 0.08054 mg/L PBTK NA 50% Human Human +DTXSID4045183 Css NA 0.5204 mg/L PBTK NA 95% Human Human +DTXSID4045183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045183 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045183 Vd NA 1.148 L/kg 1compartment NA NA Rat Human DTXSID4045183 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045183 TK.Half.Life NA 2.757 hours 1compartment NA NA Rat Human -DTXSID4045183 Css NA 0.3333 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045183 Css NA 1.259 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045183 Css NA 0.2215 mg/L PBTK NA 50% Rat Human -DTXSID4045183 Css NA 0.7517 mg/L PBTK NA 95% Rat Human -DTXSID4045187 Clint NA 8.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045187 Fup NA 0.0727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045187 Vd NA 3.095 L/kg 1compartment NA NA Human Human -DTXSID4045187 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID4045187 TK.Half.Life NA 143.2 hours 1compartment NA NA Human Human -DTXSID4045187 Css NA 5.664 mg/L 3compartmentss NA 50% Human Human -DTXSID4045187 Css NA 36.01 mg/L 3compartmentss NA 95% Human Human -DTXSID4045187 Css NA 3.947 mg/L PBTK NA 50% Human Human -DTXSID4045187 Css NA 24.21 mg/L PBTK NA 95% Human Human -DTXSID4045187 Clint NA 8.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045187 Fup NA 0.0727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045187 Vd NA 2.32 L/kg 1compartment NA NA Rat Human -DTXSID4045187 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID4045187 TK.Half.Life NA 19.56 hours 1compartment NA NA Rat Human -DTXSID4045187 Css NA 3.176 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045187 Css NA 15.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045187 Css NA 2.114 mg/L PBTK NA 50% Rat Human -DTXSID4045187 Css NA 10.14 mg/L PBTK NA 95% Rat Human -DTXSID4045189 Clint NA 5.476 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045189 Fup NA 0.249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045189 Vd NA 0.6237 L/kg 1compartment NA NA Human Human +DTXSID4045183 TK.Half.Life NA 0.9701 hours 1compartment NA NA Rat Human +DTXSID4045183 Css NA 0.01408 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045183 Css NA 0.07466 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045183 Css NA 0.01012 mg/L PBTK NA 50% Rat Human +DTXSID4045183 Css NA 0.05088 mg/L PBTK NA 95% Rat Human +DTXSID4045187 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045187 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045187 Vd NA 2.382 L/kg 1compartment NA NA Human Human +DTXSID4045187 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4045187 TK.Half.Life NA 6.442 hours 1compartment NA NA Human Human +DTXSID4045187 Css NA 0.2311 mg/L 3compartmentss NA 50% Human Human +DTXSID4045187 Css NA 1.409 mg/L 3compartmentss NA 95% Human Human +DTXSID4045187 Css NA 0.1662 mg/L PBTK NA 50% Human Human +DTXSID4045187 Css NA 0.9887 mg/L PBTK NA 95% Human Human +DTXSID4045187 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045187 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045187 Vd NA 1.814 L/kg 1compartment NA NA Rat Human +DTXSID4045187 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4045187 TK.Half.Life NA 1.875 hours 1compartment NA NA Rat Human +DTXSID4045187 Css NA 0.0294 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045187 Css NA 0.145 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045187 Css NA 0.02093 mg/L PBTK NA 50% Rat Human +DTXSID4045187 Css NA 0.09951 mg/L PBTK NA 95% Rat Human +DTXSID4045189 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045189 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045189 Vd NA 1.083 L/kg 1compartment NA NA Human Human DTXSID4045189 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045189 TK.Half.Life NA 2.016 hours 1compartment NA NA Human Human -DTXSID4045189 Css NA 0.3208 mg/L 3compartmentss NA 50% Human Human -DTXSID4045189 Css NA 1.877 mg/L 3compartmentss NA 95% Human Human -DTXSID4045189 Css NA 0.2238 mg/L PBTK NA 50% Human Human -DTXSID4045189 Css NA 1.206 mg/L PBTK NA 95% Human Human -DTXSID4045189 Clint NA 5.476 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045189 Fup NA 0.249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045189 Vd NA 0.5757 L/kg 1compartment NA NA Rat Human +DTXSID4045189 TK.Half.Life NA 1.527 hours 1compartment NA NA Human Human +DTXSID4045189 Css NA 0.1007 mg/L 3compartmentss NA 50% Human Human +DTXSID4045189 Css NA 0.9134 mg/L 3compartmentss NA 95% Human Human +DTXSID4045189 Css NA 0.08443 mg/L PBTK NA 50% Human Human +DTXSID4045189 Css NA 0.6324 mg/L PBTK NA 95% Human Human +DTXSID4045189 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045189 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045189 Vd NA 1.007 L/kg 1compartment NA NA Rat Human DTXSID4045189 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045189 TK.Half.Life NA 1.067 hours 1compartment NA NA Rat Human -DTXSID4045189 Css NA 0.1643 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045189 Css NA 0.6847 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045189 Css NA 0.1091 mg/L PBTK NA 50% Rat Human -DTXSID4045189 Css NA 0.4113 mg/L PBTK NA 95% Rat Human -DTXSID4045210 Clint NA 25.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045210 Fup NA 0.621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045210 Vd NA 2.164 L/kg 1compartment NA NA Human Human +DTXSID4045189 TK.Half.Life NA 0.7496 hours 1compartment NA NA Rat Human +DTXSID4045189 Css NA 0.01123 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045189 Css NA 0.09015 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045189 Css NA 0.009732 mg/L PBTK NA 50% Rat Human +DTXSID4045189 Css NA 0.05844 mg/L PBTK NA 95% Rat Human +DTXSID4045210 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045210 Fup 0.787 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045210 Vd NA 2.343 L/kg 1compartment NA NA Human Human DTXSID4045210 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045210 TK.Half.Life NA 1.514 hours 1compartment NA NA Human Human -DTXSID4045210 Css NA 0.023 mg/L 3compartmentss NA 50% Human Human -DTXSID4045210 Css NA 0.277 mg/L 3compartmentss NA 95% Human Human -DTXSID4045210 Css NA 0.02395 mg/L PBTK NA 50% Human Human -DTXSID4045210 Css NA 0.2127 mg/L PBTK NA 95% Human Human -DTXSID4045210 Clint NA 25.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045210 Fup NA 0.621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045210 Vd NA 2.163 L/kg 1compartment NA NA Rat Human +DTXSID4045210 TK.Half.Life NA 2.546 hours 1compartment NA NA Human Human +DTXSID4045210 Css NA 0.03356 mg/L 3compartmentss NA 50% Human Human +DTXSID4045210 Css NA 0.3738 mg/L 3compartmentss NA 95% Human Human +DTXSID4045210 Css NA 0.0362 mg/L PBTK NA 50% Human Human +DTXSID4045210 Css NA 0.297 mg/L PBTK NA 95% Human Human +DTXSID4045210 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045210 Fup 0.787 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045210 Vd NA 2.347 L/kg 1compartment NA NA Rat Human DTXSID4045210 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045210 TK.Half.Life NA 0.7665 hours 1compartment NA NA Rat Human -DTXSID4045210 Css NA 0.01173 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045210 Css NA 0.123 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045210 Css NA 0.01223 mg/L PBTK NA 50% Rat Human -DTXSID4045210 Css NA 0.08952 mg/L PBTK NA 95% Rat Human -DTXSID4045216 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045216 Fup NA 0.173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045216 Vd NA 0.3096 L/kg 1compartment NA NA Human Human +DTXSID4045210 TK.Half.Life NA 1.397 hours 1compartment NA NA Rat Human +DTXSID4045210 Css NA 0.000279 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045210 Css NA 0.003284 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045210 Css NA 0.0003047 mg/L PBTK NA 50% Rat Human +DTXSID4045210 Css NA 0.002444 mg/L PBTK NA 95% Rat Human +DTXSID4045216 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045216 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045216 Vd NA 0.3739 L/kg 1compartment NA NA Human Human DTXSID4045216 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4045216 TK.Half.Life NA 11.58 hours 1compartment NA NA Human Human -DTXSID4045216 Css NA 4.743 mg/L 3compartmentss NA 50% Human Human -DTXSID4045216 Css NA 16.74 mg/L 3compartmentss NA 95% Human Human -DTXSID4045216 Css NA 3.04 mg/L PBTK NA 50% Human Human -DTXSID4045216 Css NA 10.06 mg/L PBTK NA 95% Human Human -DTXSID4045216 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045216 Fup NA 0.173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045216 Vd NA 0.319 L/kg 1compartment NA NA Rat Human +DTXSID4045216 TK.Half.Life NA 11.92 hours 1compartment NA NA Human Human +DTXSID4045216 Css NA 3.817 mg/L 3compartmentss NA 50% Human Human +DTXSID4045216 Css NA 13.82 mg/L 3compartmentss NA 95% Human Human +DTXSID4045216 Css NA 2.524 mg/L PBTK NA 50% Human Human +DTXSID4045216 Css NA 8.375 mg/L PBTK NA 95% Human Human +DTXSID4045216 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045216 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045216 Vd NA 0.3801 L/kg 1compartment NA NA Rat Human DTXSID4045216 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045216 TK.Half.Life NA 4.065 hours 1compartment NA NA Rat Human -DTXSID4045216 Css NA 1.327 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045216 Css NA 3.903 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045216 Css NA 0.8003 mg/L PBTK NA 50% Rat Human -DTXSID4045216 Css NA 2.198 mg/L PBTK NA 95% Rat Human -DTXSID4045262 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045262 Fup NA 0.8512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045262 Vd NA 1.318 L/kg 1compartment NA NA Human Human +DTXSID4045216 TK.Half.Life NA 4.128 hours 1compartment NA NA Rat Human +DTXSID4045216 Css NA 0.2452 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045216 Css NA 0.754 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045216 Css NA 0.1591 mg/L PBTK NA 50% Rat Human +DTXSID4045216 Css NA 0.4458 mg/L PBTK NA 95% Rat Human +DTXSID4045262 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045262 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045262 Vd NA 0.9624 L/kg 1compartment NA NA Human Human DTXSID4045262 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4045262 TK.Half.Life NA 10.82 hours 1compartment NA NA Human Human -DTXSID4045262 Css NA 0.8884 mg/L 3compartmentss NA 50% Human Human -DTXSID4045262 Css NA 5.624 mg/L 3compartmentss NA 95% Human Human -DTXSID4045262 Css NA 0.8112 mg/L PBTK NA 50% Human Human -DTXSID4045262 Css NA 3.826 mg/L PBTK NA 95% Human Human -DTXSID4045262 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045262 Fup NA 0.8512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045262 Vd NA 1.219 L/kg 1compartment NA NA Rat Human +DTXSID4045262 TK.Half.Life NA 13.06 hours 1compartment NA NA Human Human +DTXSID4045262 Css NA 1.359 mg/L 3compartmentss NA 50% Human Human +DTXSID4045262 Css NA 7.369 mg/L 3compartmentss NA 95% Human Human +DTXSID4045262 Css NA 1.114 mg/L PBTK NA 50% Human Human +DTXSID4045262 Css NA 4.823 mg/L PBTK NA 95% Human Human +DTXSID4045262 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045262 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045262 Vd NA 0.8852 L/kg 1compartment NA NA Rat Human DTXSID4045262 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045262 TK.Half.Life NA 3.218 hours 1compartment NA NA Rat Human -DTXSID4045262 Css NA 0.2274 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045262 Css NA 1.415 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045262 Css NA 0.2034 mg/L PBTK NA 50% Rat Human -DTXSID4045262 Css NA 0.8802 mg/L PBTK NA 95% Rat Human -DTXSID4045341 Clint NA 46.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045341 Fup NA 0.3019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045341 Vd NA 2.353 L/kg 1compartment NA NA Human Human +DTXSID4045262 TK.Half.Life NA 3.956 hours 1compartment NA NA Rat Human +DTXSID4045262 Css NA 0.08594 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045262 Css NA 0.4062 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045262 Css NA 0.06958 mg/L PBTK NA 50% Rat Human +DTXSID4045262 Css NA 0.2549 mg/L PBTK NA 95% Rat Human +DTXSID4045341 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045341 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045341 Vd NA 1.434 L/kg 1compartment NA NA Human Human DTXSID4045341 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045341 TK.Half.Life NA 2.484 hours 1compartment NA NA Human Human -DTXSID4045341 Css NA 0.04392 mg/L 3compartmentss NA 50% Human Human -DTXSID4045341 Css NA 0.3018 mg/L 3compartmentss NA 95% Human Human -DTXSID4045341 Css NA 0.03577 mg/L PBTK NA 50% Human Human -DTXSID4045341 Css NA 0.2247 mg/L PBTK NA 95% Human Human -DTXSID4045341 Clint NA 46.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045341 Fup NA 0.3019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045341 Vd NA 1.968 L/kg 1compartment NA NA Rat Human +DTXSID4045341 TK.Half.Life NA 1.49 hours 1compartment NA NA Human Human +DTXSID4045341 Css NA 0.04339 mg/L 3compartmentss NA 50% Human Human +DTXSID4045341 Css NA 0.359 mg/L 3compartmentss NA 95% Human Human +DTXSID4045341 Css NA 0.03628 mg/L PBTK NA 50% Human Human +DTXSID4045341 Css NA 0.2583 mg/L PBTK NA 95% Human Human +DTXSID4045341 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045341 Fup 0.416 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045341 Vd NA 1.355 L/kg 1compartment NA NA Rat Human DTXSID4045341 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045341 TK.Half.Life NA 0.9287 hours 1compartment NA NA Rat Human -DTXSID4045341 Css NA 0.02362 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045341 Css NA 0.1325 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045341 Css NA 0.01874 mg/L PBTK NA 50% Rat Human -DTXSID4045341 Css NA 0.09559 mg/L PBTK NA 95% Rat Human -DTXSID4045343 Clint NA 13.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045343 Fup NA 0.0358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045343 Vd NA 0.1912 L/kg 1compartment NA NA Human Human +DTXSID4045341 TK.Half.Life NA 0.7208 hours 1compartment NA NA Rat Human +DTXSID4045341 Css NA 0.005321 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045341 Css NA 0.0359 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045341 Css NA 0.004511 mg/L PBTK NA 50% Rat Human +DTXSID4045341 Css NA 0.02606 mg/L PBTK NA 95% Rat Human +DTXSID4045343 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045343 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045343 Vd NA 0.2543 L/kg 1compartment NA NA Human Human DTXSID4045343 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045343 TK.Half.Life NA 1.615 hours 1compartment NA NA Human Human -DTXSID4045343 Css NA 1.423 mg/L 3compartmentss NA 50% Human Human -DTXSID4045343 Css NA 9.688 mg/L 3compartmentss NA 95% Human Human -DTXSID4045343 Css NA 0.841 mg/L PBTK NA 50% Human Human -DTXSID4045343 Css NA 5.72 mg/L PBTK NA 95% Human Human -DTXSID4045343 Clint NA 13.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045343 Fup NA 0.0358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045343 Vd NA 0.1896 L/kg 1compartment NA NA Rat Human +DTXSID4045343 TK.Half.Life NA 1.378 hours 1compartment NA NA Human Human +DTXSID4045343 Css NA 0.7535 mg/L 3compartmentss NA 50% Human Human +DTXSID4045343 Css NA 5.064 mg/L 3compartmentss NA 95% Human Human +DTXSID4045343 Css NA 0.4616 mg/L PBTK NA 50% Human Human +DTXSID4045343 Css NA 3.002 mg/L PBTK NA 95% Human Human +DTXSID4045343 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045343 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045343 Vd NA 0.2541 L/kg 1compartment NA NA Rat Human DTXSID4045343 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045343 TK.Half.Life NA 1.031 hours 1compartment NA NA Rat Human -DTXSID4045343 Css NA 0.7886 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045343 Css NA 4.037 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045343 Css NA 0.4333 mg/L PBTK NA 50% Rat Human -DTXSID4045343 Css NA 2.192 mg/L PBTK NA 95% Rat Human -DTXSID4045345 Clint NA 0.863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045345 Fup NA 0.7885 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045345 Vd NA 3.309 L/kg 1compartment NA NA Human Human -DTXSID4045345 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045345 TK.Half.Life NA 11.57 hours 1compartment NA NA Human Human -DTXSID4045345 Css NA 0.2787 mg/L 3compartmentss NA 50% Human Human -DTXSID4045345 Css NA 2.302 mg/L 3compartmentss NA 95% Human Human -DTXSID4045345 Css NA 0.3402 mg/L PBTK NA 50% Human Human -DTXSID4045345 Css NA 1.748 mg/L PBTK NA 95% Human Human -DTXSID4045345 Clint NA 0.863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045345 Fup NA 0.7885 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045345 Vd NA 3.373 L/kg 1compartment NA NA Rat Human +DTXSID4045343 TK.Half.Life NA 0.8312 hours 1compartment NA NA Rat Human +DTXSID4045343 Css NA 0.0914 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045343 Css NA 0.4657 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045343 Css NA 0.0546 mg/L PBTK NA 50% Rat Human +DTXSID4045343 Css NA 0.2677 mg/L PBTK NA 95% Rat Human +DTXSID4045345 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045345 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045345 Vd NA 1.744 L/kg 1compartment NA NA Human Human +DTXSID4045345 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4045345 TK.Half.Life NA 22.76 hours 1compartment NA NA Human Human +DTXSID4045345 Css NA 1.146 mg/L 3compartmentss NA 50% Human Human +DTXSID4045345 Css NA 6.682 mg/L 3compartmentss NA 95% Human Human +DTXSID4045345 Css NA 1.075 mg/L PBTK NA 50% Human Human +DTXSID4045345 Css NA 4.575 mg/L PBTK NA 95% Human Human +DTXSID4045345 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045345 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045345 Vd NA 1.761 L/kg 1compartment NA NA Rat Human DTXSID4045345 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045345 TK.Half.Life NA 5.635 hours 1compartment NA NA Rat Human -DTXSID4045345 Css NA 0.09942 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045345 Css NA 0.8081 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045345 Css NA 0.1226 mg/L PBTK NA 50% Rat Human -DTXSID4045345 Css NA 0.5641 mg/L PBTK NA 95% Rat Human -DTXSID4045347 Clint NA 10.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045347 Fup NA 0.0702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045347 Vd NA 3.114 L/kg 1compartment NA NA Human Human -DTXSID4045347 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID4045347 TK.Half.Life NA 78.78 hours 1compartment NA NA Human Human -DTXSID4045347 Css NA 3.084 mg/L 3compartmentss NA 50% Human Human -DTXSID4045347 Css NA 18.59 mg/L 3compartmentss NA 95% Human Human -DTXSID4045347 Css NA 2.18 mg/L PBTK NA 50% Human Human -DTXSID4045347 Css NA 12.54 mg/L PBTK NA 95% Human Human -DTXSID4045347 Clint NA 10.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045347 Fup NA 0.0702 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045347 Vd NA 2.366 L/kg 1compartment NA NA Rat Human -DTXSID4045347 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID4045347 TK.Half.Life NA 12.16 hours 1compartment NA NA Rat Human -DTXSID4045347 Css NA 1.68 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045347 Css NA 8.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045347 Css NA 1.139 mg/L PBTK NA 50% Rat Human -DTXSID4045347 Css NA 5.565 mg/L PBTK NA 95% Rat Human -DTXSID4045391 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045391 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045391 Vd NA 3.729 L/kg 1compartment NA NA Human Human -DTXSID4045391 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4045391 TK.Half.Life NA 24.18 hours 1compartment NA NA Human Human -DTXSID4045391 Css NA 0.5367 mg/L 3compartmentss NA 50% Human Human -DTXSID4045391 Css NA 4.941 mg/L 3compartmentss NA 95% Human Human -DTXSID4045391 Css NA 0.6964 mg/L PBTK NA 50% Human Human -DTXSID4045391 Css NA 3.676 mg/L PBTK NA 95% Human Human -DTXSID4045391 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045391 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045391 Vd NA 3.809 L/kg 1compartment NA NA Rat Human +DTXSID4045345 TK.Half.Life NA 7.83 hours 1compartment NA NA Rat Human +DTXSID4045345 Css NA 0.07134 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045345 Css NA 0.3607 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045345 Css NA 0.06728 mg/L PBTK NA 50% Rat Human +DTXSID4045345 Css NA 0.2399 mg/L PBTK NA 95% Rat Human +DTXSID4045347 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045347 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045347 Vd NA 3.135 L/kg 1compartment NA NA Human Human +DTXSID4045347 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4045347 TK.Half.Life NA 27.68 hours 1compartment NA NA Human Human +DTXSID4045347 Css NA 0.9729 mg/L 3compartmentss NA 50% Human Human +DTXSID4045347 Css NA 6.24 mg/L 3compartmentss NA 95% Human Human +DTXSID4045347 Css NA 0.7021 mg/L PBTK NA 50% Human Human +DTXSID4045347 Css NA 4.33 mg/L PBTK NA 95% Human Human +DTXSID4045347 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045347 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045347 Vd NA 2.408 L/kg 1compartment NA NA Rat Human +DTXSID4045347 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4045347 TK.Half.Life NA 4.857 hours 1compartment NA NA Rat Human +DTXSID4045347 Css NA 0.125 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045347 Css NA 0.6727 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045347 Css NA 0.08908 mg/L PBTK NA 50% Rat Human +DTXSID4045347 Css NA 0.4662 mg/L PBTK NA 95% Rat Human +DTXSID4045391 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045391 Fup 0.742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045391 Vd NA 1.854 L/kg 1compartment NA NA Human Human +DTXSID4045391 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4045391 TK.Half.Life NA 16.17 hours 1compartment NA NA Human Human +DTXSID4045391 Css NA 0.7372 mg/L 3compartmentss NA 50% Human Human +DTXSID4045391 Css NA 5.4 mg/L 3compartmentss NA 95% Human Human +DTXSID4045391 Css NA 0.7366 mg/L PBTK NA 50% Human Human +DTXSID4045391 Css NA 3.674 mg/L PBTK NA 95% Human Human +DTXSID4045391 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045391 Fup 0.742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045391 Vd NA 1.882 L/kg 1compartment NA NA Rat Human DTXSID4045391 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045391 TK.Half.Life NA 8.403 hours 1compartment NA NA Rat Human -DTXSID4045391 Css NA 0.1303 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045391 Css NA 1.051 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045391 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID4045391 Css NA 0.7549 mg/L PBTK NA 95% Rat Human -DTXSID4045393 Clint NA 43.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045393 Fup NA 0.1865 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045393 Vd NA 2.31 L/kg 1compartment NA NA Human Human +DTXSID4045391 TK.Half.Life NA 5.59 hours 1compartment NA NA Rat Human +DTXSID4045391 Css NA 0.01865 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045391 Css NA 0.1565 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045391 Css NA 0.01841 mg/L PBTK NA 50% Rat Human +DTXSID4045391 Css NA 0.11 mg/L PBTK NA 95% Rat Human +DTXSID4045393 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045393 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045393 Vd NA 3.873 L/kg 1compartment NA NA Human Human DTXSID4045393 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045393 TK.Half.Life NA 2.355 hours 1compartment NA NA Human Human -DTXSID4045393 Css NA 0.04283 mg/L 3compartmentss NA 50% Human Human -DTXSID4045393 Css NA 0.3345 mg/L 3compartmentss NA 95% Human Human -DTXSID4045393 Css NA 0.03889 mg/L PBTK NA 50% Human Human -DTXSID4045393 Css NA 0.2663 mg/L PBTK NA 95% Human Human -DTXSID4045393 Clint NA 43.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045393 Fup NA 0.1865 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045393 Vd NA 2.308 L/kg 1compartment NA NA Rat Human +DTXSID4045393 TK.Half.Life NA 7.011 hours 1compartment NA NA Human Human +DTXSID4045393 Css NA 0.1005 mg/L 3compartmentss NA 50% Human Human +DTXSID4045393 Css NA 0.7656 mg/L 3compartmentss NA 95% Human Human +DTXSID4045393 Css NA 0.1232 mg/L PBTK NA 50% Human Human +DTXSID4045393 Css NA 0.7072 mg/L PBTK NA 95% Human Human +DTXSID4045393 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045393 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045393 Vd NA 3.908 L/kg 1compartment NA NA Rat Human DTXSID4045393 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045393 TK.Half.Life NA 1.254 hours 1compartment NA NA Rat Human -DTXSID4045393 Css NA 0.02285 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045393 Css NA 0.1439 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045393 Css NA 0.02031 mg/L PBTK NA 50% Rat Human -DTXSID4045393 Css NA 0.1086 mg/L PBTK NA 95% Rat Human -DTXSID4045399 Clint NA 17.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045399 Fup NA 0.0762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045399 Vd NA 3.073 L/kg 1compartment NA NA Human Human -DTXSID4045399 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID4045399 TK.Half.Life NA 58.64 hours 1compartment NA NA Human Human -DTXSID4045399 Css NA 2.303 mg/L 3compartmentss NA 50% Human Human -DTXSID4045399 Css NA 14.62 mg/L 3compartmentss NA 95% Human Human -DTXSID4045399 Css NA 1.611 mg/L PBTK NA 50% Human Human -DTXSID4045399 Css NA 9.733 mg/L PBTK NA 95% Human Human -DTXSID4045399 Clint NA 17.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045399 Fup NA 0.0762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045399 Vd NA 2.304 L/kg 1compartment NA NA Rat Human -DTXSID4045399 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID4045399 TK.Half.Life NA 8.596 hours 1compartment NA NA Rat Human -DTXSID4045399 Css NA 1.28 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045399 Css NA 6.506 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045399 Css NA 0.8528 mg/L PBTK NA 50% Rat Human -DTXSID4045399 Css NA 4.275 mg/L PBTK NA 95% Rat Human -DTXSID4045420 Clint NA 5.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4045393 TK.Half.Life NA 3.993 hours 1compartment NA NA Rat Human +DTXSID4045393 Css NA 0.01132 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045393 Css NA 0.06955 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045393 Css NA 0.01464 mg/L PBTK NA 50% Rat Human +DTXSID4045393 Css NA 0.06225 mg/L PBTK NA 95% Rat Human +DTXSID4045399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045399 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045399 Vd NA 0.63 L/kg 1compartment NA NA Human Human +DTXSID4045399 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4045399 TK.Half.Life NA 0.8509 hours 1compartment NA NA Human Human +DTXSID4045399 Css NA 0.07208 mg/L 3compartmentss NA 50% Human Human +DTXSID4045399 Css NA 0.5327 mg/L 3compartmentss NA 95% Human Human +DTXSID4045399 Css NA 0.05068 mg/L PBTK NA 50% Human Human +DTXSID4045399 Css NA 0.3552 mg/L PBTK NA 95% Human Human +DTXSID4045399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045399 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045399 Vd NA 0.5919 L/kg 1compartment NA NA Rat Human +DTXSID4045399 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4045399 TK.Half.Life NA 0.425 hours 1compartment NA NA Rat Human +DTXSID4045399 Css NA 0.009092 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045399 Css NA 0.05196 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045399 Css NA 0.006373 mg/L PBTK NA 50% Rat Human +DTXSID4045399 Css NA 0.0335 mg/L PBTK NA 95% Rat Human +DTXSID4045420 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4045420 Fup 0.88 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4045420 Vd NA 1.06 L/kg 1compartment NA NA Human Human DTXSID4045420 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045420 TK.Half.Life NA 1.262 hours 1compartment NA NA Human Human -DTXSID4045420 Css NA 0.09406 mg/L 3compartmentss NA 50% Human Human -DTXSID4045420 Css NA 0.7488 mg/L 3compartmentss NA 95% Human Human -DTXSID4045420 Css NA 0.08132 mg/L PBTK NA 50% Human Human -DTXSID4045420 Css NA 0.539 mg/L PBTK NA 95% Human Human -DTXSID4045420 Clint NA 5.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4045420 TK.Half.Life NA 7.991 hours 1compartment NA NA Human Human +DTXSID4045420 Css NA 0.8536 mg/L 3compartmentss NA 50% Human Human +DTXSID4045420 Css NA 5.069 mg/L 3compartmentss NA 95% Human Human +DTXSID4045420 Css NA 0.7566 mg/L PBTK NA 50% Human Human +DTXSID4045420 Css NA 3.321 mg/L PBTK NA 95% Human Human +DTXSID4045420 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4045420 Fup 0.88 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4045420 Vd NA 1.033 L/kg 1compartment NA NA Rat Human DTXSID4045420 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045420 TK.Half.Life NA 0.6436 hours 1compartment NA NA Rat Human -DTXSID4045420 Css NA 0.04374 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045420 Css NA 0.3058 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045420 Css NA 0.03791 mg/L PBTK NA 50% Rat Human -DTXSID4045420 Css NA 0.1999 mg/L PBTK NA 95% Rat Human -DTXSID4045422 Clint NA 178.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045422 Fup NA 0.2558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045422 Vd NA 0.5203 L/kg 1compartment NA NA Human Human +DTXSID4045420 TK.Half.Life NA 2.604 hours 1compartment NA NA Rat Human +DTXSID4045420 Css NA 0.05082 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045420 Css NA 0.2911 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045420 Css NA 0.04548 mg/L PBTK NA 50% Rat Human +DTXSID4045420 Css NA 0.1867 mg/L PBTK NA 95% Rat Human +DTXSID4045422 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045422 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045422 Vd NA 0.6698 L/kg 1compartment NA NA Human Human DTXSID4045422 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045422 TK.Half.Life NA 0.464 hours 1compartment NA NA Human Human -DTXSID4045422 Css NA 0.01105 mg/L 3compartmentss NA 50% Human Human -DTXSID4045422 Css NA 0.08712 mg/L 3compartmentss NA 95% Human Human -DTXSID4045422 Css NA 0.007501 mg/L PBTK NA 50% Human Human -DTXSID4045422 Css NA 0.0562 mg/L PBTK NA 95% Human Human -DTXSID4045422 Clint NA 178.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045422 Fup NA 0.2558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045422 Vd NA 0.4824 L/kg 1compartment NA NA Rat Human +DTXSID4045422 TK.Half.Life NA 1.354 hours 1compartment NA NA Human Human +DTXSID4045422 Css NA 0.1641 mg/L 3compartmentss NA 50% Human Human +DTXSID4045422 Css NA 1.079 mg/L 3compartmentss NA 95% Human Human +DTXSID4045422 Css NA 0.12 mg/L PBTK NA 50% Human Human +DTXSID4045422 Css NA 0.7194 mg/L PBTK NA 95% Human Human +DTXSID4045422 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045422 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045422 Vd NA 0.6224 L/kg 1compartment NA NA Rat Human DTXSID4045422 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045422 TK.Half.Life NA 0.1964 hours 1compartment NA NA Rat Human -DTXSID4045422 Css NA 0.006168 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045422 Css NA 0.03679 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045422 Css NA 0.003954 mg/L PBTK NA 50% Rat Human -DTXSID4045422 Css NA 0.02325 mg/L PBTK NA 95% Rat Human -DTXSID4045424 Clint NA 1.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045424 Fup NA 0.1315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045424 Vd NA 0.2392 L/kg 1compartment NA NA Human Human +DTXSID4045422 TK.Half.Life NA 0.694 hours 1compartment NA NA Rat Human +DTXSID4045422 Css NA 0.01874 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045422 Css NA 0.09607 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045422 Css NA 0.01373 mg/L PBTK NA 50% Rat Human +DTXSID4045422 Css NA 0.06127 mg/L PBTK NA 95% Rat Human +DTXSID4045424 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045424 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045424 Vd NA 0.6479 L/kg 1compartment NA NA Human Human DTXSID4045424 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045424 TK.Half.Life NA 3.519 hours 1compartment NA NA Human Human -DTXSID4045424 Css NA 2.271 mg/L 3compartmentss NA 50% Human Human -DTXSID4045424 Css NA 11.78 mg/L 3compartmentss NA 95% Human Human -DTXSID4045424 Css NA 1.382 mg/L PBTK NA 50% Human Human -DTXSID4045424 Css NA 6.921 mg/L PBTK NA 95% Human Human -DTXSID4045424 Clint NA 1.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045424 Fup NA 0.1315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045424 Vd NA 0.2414 L/kg 1compartment NA NA Rat Human +DTXSID4045424 TK.Half.Life NA 6.897 hours 1compartment NA NA Human Human +DTXSID4045424 Css NA 1.163 mg/L 3compartmentss NA 50% Human Human +DTXSID4045424 Css NA 7.955 mg/L 3compartmentss NA 95% Human Human +DTXSID4045424 Css NA 0.9362 mg/L PBTK NA 50% Human Human +DTXSID4045424 Css NA 4.991 mg/L PBTK NA 95% Human Human +DTXSID4045424 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045424 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045424 Vd NA 0.663 L/kg 1compartment NA NA Rat Human DTXSID4045424 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045424 TK.Half.Life NA 1.876 hours 1compartment NA NA Rat Human -DTXSID4045424 Css NA 0.9974 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045424 Css NA 4.277 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045424 Css NA 0.5692 mg/L PBTK NA 50% Rat Human -DTXSID4045424 Css NA 2.345 mg/L PBTK NA 95% Rat Human -DTXSID4045428 Clint NA 6.626 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045428 Fup NA 0.2237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045428 Vd NA 1.492 L/kg 1compartment NA NA Human Human -DTXSID4045428 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045428 TK.Half.Life NA 4.969 hours 1compartment NA NA Human Human -DTXSID4045428 Css NA 0.3194 mg/L 3compartmentss NA 50% Human Human -DTXSID4045428 Css NA 1.857 mg/L 3compartmentss NA 95% Human Human -DTXSID4045428 Css NA 0.2394 mg/L PBTK NA 50% Human Human -DTXSID4045428 Css NA 1.29 mg/L PBTK NA 95% Human Human -DTXSID4045428 Clint NA 6.626 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045428 Fup NA 0.2237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045428 Vd NA 1.262 L/kg 1compartment NA NA Rat Human +DTXSID4045424 TK.Half.Life NA 2.405 hours 1compartment NA NA Rat Human +DTXSID4045424 Css NA 0.07123 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045424 Css NA 0.4588 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045424 Css NA 0.05722 mg/L PBTK NA 50% Rat Human +DTXSID4045424 Css NA 0.2793 mg/L PBTK NA 95% Rat Human +DTXSID4045428 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045428 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045428 Vd NA 1.057 L/kg 1compartment NA NA Human Human +DTXSID4045428 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4045428 TK.Half.Life NA 22.61 hours 1compartment NA NA Human Human +DTXSID4045428 Css NA 1.968 mg/L 3compartmentss NA 50% Human Human +DTXSID4045428 Css NA 8.274 mg/L 3compartmentss NA 95% Human Human +DTXSID4045428 Css NA 1.503 mg/L PBTK NA 50% Human Human +DTXSID4045428 Css NA 5.365 mg/L PBTK NA 95% Human Human +DTXSID4045428 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045428 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045428 Vd NA 0.9803 L/kg 1compartment NA NA Rat Human DTXSID4045428 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045428 TK.Half.Life NA 2.221 hours 1compartment NA NA Rat Human -DTXSID4045428 Css NA 0.1629 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045428 Css NA 0.7139 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045428 Css NA 0.1169 mg/L PBTK NA 50% Rat Human -DTXSID4045428 Css NA 0.4568 mg/L PBTK NA 95% Rat Human -DTXSID4045472 Clint NA 73.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045472 Fup NA 0.0676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045472 Vd NA 1.74 L/kg 1compartment NA NA Human Human +DTXSID4045428 TK.Half.Life NA 6.911 hours 1compartment NA NA Rat Human +DTXSID4045428 Css NA 0.04676 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045428 Css NA 0.2768 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045428 Css NA 0.03566 mg/L PBTK NA 50% Rat Human +DTXSID4045428 Css NA 0.1807 mg/L PBTK NA 95% Rat Human +DTXSID4045472 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045472 Fup 0.0653 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045472 Vd NA 1.717 L/kg 1compartment NA NA Human Human DTXSID4045472 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045472 TK.Half.Life NA 3.127 hours 1compartment NA NA Human Human -DTXSID4045472 Css NA 0.1437 mg/L 3compartmentss NA 50% Human Human -DTXSID4045472 Css NA 1.006 mg/L 3compartmentss NA 95% Human Human -DTXSID4045472 Css NA 0.09429 mg/L PBTK NA 50% Human Human -DTXSID4045472 Css NA 0.6345 mg/L PBTK NA 95% Human Human -DTXSID4045472 Clint NA 73.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045472 Fup NA 0.0676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045472 Vd NA 1.312 L/kg 1compartment NA NA Rat Human +DTXSID4045472 TK.Half.Life NA 7.005 hours 1compartment NA NA Human Human +DTXSID4045472 Css NA 0.4911 mg/L 3compartmentss NA 50% Human Human +DTXSID4045472 Css NA 3.391 mg/L 3compartmentss NA 95% Human Human +DTXSID4045472 Css NA 0.3212 mg/L PBTK NA 50% Human Human +DTXSID4045472 Css NA 2.139 mg/L PBTK NA 95% Human Human +DTXSID4045472 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045472 Fup 0.0653 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045472 Vd NA 1.294 L/kg 1compartment NA NA Rat Human DTXSID4045472 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045472 TK.Half.Life NA 1.103 hours 1compartment NA NA Rat Human -DTXSID4045472 Css NA 0.0807 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045472 Css NA 0.4472 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045472 Css NA 0.05036 mg/L PBTK NA 50% Rat Human -DTXSID4045472 Css NA 0.2775 mg/L PBTK NA 95% Rat Human -DTXSID4045474 Clint NA 11.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045474 Fup NA 0.0638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045474 Vd NA 2.313 L/kg 1compartment NA NA Human Human -DTXSID4045474 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4045474 TK.Half.Life NA 20.14 hours 1compartment NA NA Human Human -DTXSID4045474 Css NA 1.173 mg/L 3compartmentss NA 50% Human Human -DTXSID4045474 Css NA 7.478 mg/L 3compartmentss NA 95% Human Human -DTXSID4045474 Css NA 0.7901 mg/L PBTK NA 50% Human Human -DTXSID4045474 Css NA 4.763 mg/L PBTK NA 95% Human Human -DTXSID4045474 Clint NA 11.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045474 Fup NA 0.0638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045474 Vd NA 1.749 L/kg 1compartment NA NA Rat Human +DTXSID4045472 TK.Half.Life NA 2.537 hours 1compartment NA NA Rat Human +DTXSID4045472 Css NA 0.06312 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045472 Css NA 0.3502 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045472 Css NA 0.04028 mg/L PBTK NA 50% Rat Human +DTXSID4045472 Css NA 0.2156 mg/L PBTK NA 95% Rat Human +DTXSID4045474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045474 Fup 0.0494 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045474 Vd NA 2.84 L/kg 1compartment NA NA Human Human +DTXSID4045474 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4045474 TK.Half.Life NA 28.45 hours 1compartment NA NA Human Human +DTXSID4045474 Css NA 1.213 mg/L 3compartmentss NA 50% Human Human +DTXSID4045474 Css NA 8.121 mg/L 3compartmentss NA 95% Human Human +DTXSID4045474 Css NA 0.8333 mg/L PBTK NA 50% Human Human +DTXSID4045474 Css NA 5.286 mg/L PBTK NA 95% Human Human +DTXSID4045474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045474 Fup 0.0494 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045474 Vd NA 2.135 L/kg 1compartment NA NA Rat Human DTXSID4045474 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4045474 TK.Half.Life NA 5.743 hours 1compartment NA NA Rat Human -DTXSID4045474 Css NA 0.6415 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045474 Css NA 3.087 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045474 Css NA 0.4115 mg/L PBTK NA 50% Rat Human -DTXSID4045474 Css NA 1.908 mg/L PBTK NA 95% Rat Human +DTXSID4045474 TK.Half.Life NA 5.631 hours 1compartment NA NA Rat Human +DTXSID4045474 Css NA 0.1584 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045474 Css NA 0.8586 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045474 Css NA 0.1072 mg/L PBTK NA 50% Rat Human +DTXSID4045474 Css NA 0.564 mg/L PBTK NA 95% Rat Human DTXSID4045476 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4045476 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045476 Vd NA 0.7831 L/kg 1compartment NA NA Human Human +DTXSID4045476 Vd NA 1.405 L/kg 1compartment NA NA Human Human DTXSID4045476 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045476 TK.Half.Life NA 5.067 hours 1compartment NA NA Human Human -DTXSID4045476 Css NA 0.8312 mg/L 3compartmentss NA 50% Human Human -DTXSID4045476 Css NA 5.524 mg/L 3compartmentss NA 95% Human Human -DTXSID4045476 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID4045476 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID4045476 TK.Half.Life NA 9.604 hours 1compartment NA NA Human Human +DTXSID4045476 Css NA 0.4034 mg/L 3compartmentss NA 50% Human Human +DTXSID4045476 Css NA 3.071 mg/L 3compartmentss NA 95% Human Human +DTXSID4045476 Css NA 0.3832 mg/L PBTK NA 50% Human Human +DTXSID4045476 Css NA 2.146 mg/L PBTK NA 95% Human Human DTXSID4045476 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4045476 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045476 Vd NA 0.8252 L/kg 1compartment NA NA Rat Human +DTXSID4045476 Vd NA 1.343 L/kg 1compartment NA NA Rat Human DTXSID4045476 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045476 TK.Half.Life NA 1.819 hours 1compartment NA NA Rat Human -DTXSID4045476 Css NA 0.2087 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045476 Css NA 1.331 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045476 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID4045476 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID4045478 Clint NA 136.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045478 Fup NA 0.5198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045478 Vd NA 1.127 L/kg 1compartment NA NA Human Human +DTXSID4045476 TK.Half.Life NA 3.001 hours 1compartment NA NA Rat Human +DTXSID4045476 Css NA 0.002013 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045476 Css NA 0.01526 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045476 Css NA 0.001898 mg/L PBTK NA 50% Rat Human +DTXSID4045476 Css NA 0.01064 mg/L PBTK NA 95% Rat Human +DTXSID4045478 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045478 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045478 Vd NA 1.5 L/kg 1compartment NA NA Human Human DTXSID4045478 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045478 TK.Half.Life NA 0.7758 hours 1compartment NA NA Human Human -DTXSID4045478 Css NA 0.006494 mg/L 3compartmentss NA 50% Human Human -DTXSID4045478 Css NA 0.06372 mg/L 3compartmentss NA 95% Human Human -DTXSID4045478 Css NA 0.005354 mg/L PBTK NA 50% Human Human -DTXSID4045478 Css NA 0.04468 mg/L PBTK NA 95% Human Human -DTXSID4045478 Clint NA 136.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045478 Fup NA 0.5198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045478 Vd NA 1.032 L/kg 1compartment NA NA Rat Human +DTXSID4045478 TK.Half.Life NA 2.281 hours 1compartment NA NA Human Human +DTXSID4045478 Css NA 0.1063 mg/L 3compartmentss NA 50% Human Human +DTXSID4045478 Css NA 0.9864 mg/L 3compartmentss NA 95% Human Human +DTXSID4045478 Css NA 0.09332 mg/L PBTK NA 50% Human Human +DTXSID4045478 Css NA 0.686 mg/L PBTK NA 95% Human Human +DTXSID4045478 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045478 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045478 Vd NA 1.327 L/kg 1compartment NA NA Rat Human DTXSID4045478 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045478 TK.Half.Life NA 0.318 hours 1compartment NA NA Rat Human -DTXSID4045478 Css NA 0.003478 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045478 Css NA 0.02882 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045478 Css NA 0.002786 mg/L PBTK NA 50% Rat Human -DTXSID4045478 Css NA 0.02003 mg/L PBTK NA 95% Rat Human -DTXSID4045551 Clint NA 2.665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045551 Fup NA 0.0378 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045551 Vd NA 0.2439 L/kg 1compartment NA NA Human Human +DTXSID4045478 TK.Half.Life NA 1.027 hours 1compartment NA NA Rat Human +DTXSID4045478 Css NA 0.01206 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045478 Css NA 0.09437 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045478 Css NA 0.01079 mg/L PBTK NA 50% Rat Human +DTXSID4045478 Css NA 0.06245 mg/L PBTK NA 95% Rat Human +DTXSID4045551 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045551 Fup 0.0608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045551 Vd NA 0.2884 L/kg 1compartment NA NA Human Human DTXSID4045551 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045551 TK.Half.Life NA 7.87 hours 1compartment NA NA Human Human -DTXSID4045551 Css NA 5.874 mg/L 3compartmentss NA 50% Human Human -DTXSID4045551 Css NA 39.69 mg/L 3compartmentss NA 95% Human Human -DTXSID4045551 Css NA 3.51 mg/L PBTK NA 50% Human Human -DTXSID4045551 Css NA 23.07 mg/L PBTK NA 95% Human Human -DTXSID4045551 Clint NA 2.665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045551 Fup NA 0.0378 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045551 Vd NA 0.2385 L/kg 1compartment NA NA Rat Human +DTXSID4045551 TK.Half.Life NA 2.926 hours 1compartment NA NA Human Human +DTXSID4045551 Css NA 1.418 mg/L 3compartmentss NA 50% Human Human +DTXSID4045551 Css NA 9.674 mg/L 3compartmentss NA 95% Human Human +DTXSID4045551 Css NA 0.874 mg/L PBTK NA 50% Human Human +DTXSID4045551 Css NA 5.777 mg/L PBTK NA 95% Human Human +DTXSID4045551 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045551 Fup 0.0608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045551 Vd NA 0.2822 L/kg 1compartment NA NA Rat Human DTXSID4045551 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045551 TK.Half.Life NA 4.478 hours 1compartment NA NA Rat Human -DTXSID4045551 Css NA 2.838 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045551 Css NA 15.11 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045551 Css NA 1.588 mg/L PBTK NA 50% Rat Human -DTXSID4045551 Css NA 8.252 mg/L PBTK NA 95% Rat Human -DTXSID4045555 Clint NA 3.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045555 Fup NA 0.6341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045555 Vd NA 0.9136 L/kg 1compartment NA NA Human Human +DTXSID4045551 TK.Half.Life NA 1.778 hours 1compartment NA NA Rat Human +DTXSID4045551 Css NA 0.06328 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045551 Css NA 0.5109 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045551 Css NA 0.03742 mg/L PBTK NA 50% Rat Human +DTXSID4045551 Css NA 0.2935 mg/L PBTK NA 95% Rat Human +DTXSID4045555 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045555 Fup 0.859 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045555 Vd NA 0.8592 L/kg 1compartment NA NA Human Human DTXSID4045555 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045555 TK.Half.Life NA 1.976 hours 1compartment NA NA Human Human -DTXSID4045555 Css NA 0.2008 mg/L 3compartmentss NA 50% Human Human -DTXSID4045555 Css NA 1.611 mg/L 3compartmentss NA 95% Human Human -DTXSID4045555 Css NA 0.1662 mg/L PBTK NA 50% Human Human -DTXSID4045555 Css NA 1.064 mg/L PBTK NA 95% Human Human -DTXSID4045555 Clint NA 3.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045555 Fup NA 0.6341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045555 Vd NA 0.8781 L/kg 1compartment NA NA Rat Human +DTXSID4045555 TK.Half.Life NA 6.508 hours 1compartment NA NA Human Human +DTXSID4045555 Css NA 0.9058 mg/L 3compartmentss NA 50% Human Human +DTXSID4045555 Css NA 5.416 mg/L 3compartmentss NA 95% Human Human +DTXSID4045555 Css NA 0.7704 mg/L PBTK NA 50% Human Human +DTXSID4045555 Css NA 3.509 mg/L PBTK NA 95% Human Human +DTXSID4045555 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045555 Fup 0.859 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045555 Vd NA 0.8711 L/kg 1compartment NA NA Rat Human DTXSID4045555 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045555 TK.Half.Life NA 1.011 hours 1compartment NA NA Rat Human -DTXSID4045555 Css NA 0.09076 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045555 Css NA 0.6726 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045555 Css NA 0.07336 mg/L PBTK NA 50% Rat Human -DTXSID4045555 Css NA 0.4078 mg/L PBTK NA 95% Rat Human -DTXSID4045557 Clint NA 10.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045557 Fup NA 0.0771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045557 Vd NA 2.523 L/kg 1compartment NA NA Human Human +DTXSID4045555 TK.Half.Life NA 2.24 hours 1compartment NA NA Rat Human +DTXSID4045555 Css NA 0.05301 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045555 Css NA 0.3131 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045555 Css NA 0.04546 mg/L PBTK NA 50% Rat Human +DTXSID4045555 Css NA 0.1967 mg/L PBTK NA 95% Rat Human +DTXSID4045557 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045557 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045557 Vd NA 0.8364 L/kg 1compartment NA NA Human Human DTXSID4045557 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045557 TK.Half.Life NA 7.173 hours 1compartment NA NA Human Human -DTXSID4045557 Css NA 0.2851 mg/L 3compartmentss NA 50% Human Human -DTXSID4045557 Css NA 2.574 mg/L 3compartmentss NA 95% Human Human -DTXSID4045557 Css NA 0.2457 mg/L PBTK NA 50% Human Human -DTXSID4045557 Css NA 1.859 mg/L PBTK NA 95% Human Human -DTXSID4045557 Clint NA 10.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045557 Fup NA 0.0771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045557 Vd NA 2.474 L/kg 1compartment NA NA Rat Human +DTXSID4045557 TK.Half.Life NA 1.492 hours 1compartment NA NA Human Human +DTXSID4045557 Css NA 0.1212 mg/L 3compartmentss NA 50% Human Human +DTXSID4045557 Css NA 0.8942 mg/L 3compartmentss NA 95% Human Human +DTXSID4045557 Css NA 0.0859 mg/L PBTK NA 50% Human Human +DTXSID4045557 Css NA 0.5874 mg/L PBTK NA 95% Human Human +DTXSID4045557 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045557 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045557 Vd NA 0.8302 L/kg 1compartment NA NA Rat Human DTXSID4045557 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045557 TK.Half.Life NA 4.224 hours 1compartment NA NA Rat Human -DTXSID4045557 Css NA 0.156 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045557 Css NA 1.094 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045557 Css NA 0.1293 mg/L PBTK NA 50% Rat Human -DTXSID4045557 Css NA 0.7561 mg/L PBTK NA 95% Rat Human -DTXSID4045559 Clint NA 4.477 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045559 Fup NA 0.3888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045559 Vd NA 0.3192 L/kg 1compartment NA NA Human Human +DTXSID4045557 TK.Half.Life NA 0.8426 hours 1compartment NA NA Rat Human +DTXSID4045557 Css NA 0.01554 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045557 Css NA 0.0843 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045557 Css NA 0.0108 mg/L PBTK NA 50% Rat Human +DTXSID4045557 Css NA 0.05462 mg/L PBTK NA 95% Rat Human +DTXSID4045559 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045559 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045559 Vd NA 0.3755 L/kg 1compartment NA NA Human Human DTXSID4045559 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045559 TK.Half.Life NA 0.8164 hours 1compartment NA NA Human Human -DTXSID4045559 Css NA 0.2509 mg/L 3compartmentss NA 50% Human Human -DTXSID4045559 Css NA 1.504 mg/L 3compartmentss NA 95% Human Human -DTXSID4045559 Css NA 0.167 mg/L PBTK NA 50% Human Human -DTXSID4045559 Css NA 0.9401 mg/L PBTK NA 95% Human Human -DTXSID4045559 Clint NA 4.477 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045559 Fup NA 0.3888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045559 Vd NA 0.331 L/kg 1compartment NA NA Rat Human +DTXSID4045559 TK.Half.Life NA 6.769 hours 1compartment NA NA Human Human +DTXSID4045559 Css NA 1.164 mg/L 3compartmentss NA 50% Human Human +DTXSID4045559 Css NA 5.03 mg/L 3compartmentss NA 95% Human Human +DTXSID4045559 Css NA 0.7965 mg/L PBTK NA 50% Human Human +DTXSID4045559 Css NA 3.104 mg/L PBTK NA 95% Human Human +DTXSID4045559 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045559 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045559 Vd NA 0.3789 L/kg 1compartment NA NA Rat Human DTXSID4045559 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045559 TK.Half.Life NA 0.4706 hours 1compartment NA NA Rat Human -DTXSID4045559 Css NA 0.1257 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045559 Css NA 0.5498 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045559 Css NA 0.07921 mg/L PBTK NA 50% Rat Human -DTXSID4045559 Css NA 0.3179 mg/L PBTK NA 95% Rat Human -DTXSID4045630 Clint NA 0.6529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045630 Fup NA 0.8889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045630 Vd NA 1.419 L/kg 1compartment NA NA Human Human -DTXSID4045630 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045630 TK.Half.Life NA 5.15 hours 1compartment NA NA Human Human -DTXSID4045630 Css NA 0.4018 mg/L 3compartmentss NA 50% Human Human -DTXSID4045630 Css NA 2.547 mg/L 3compartmentss NA 95% Human Human -DTXSID4045630 Css NA 0.3706 mg/L PBTK NA 50% Human Human -DTXSID4045630 Css NA 1.727 mg/L PBTK NA 95% Human Human -DTXSID4045630 Clint NA 0.6529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045630 Fup NA 0.8889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045630 Vd NA 1.458 L/kg 1compartment NA NA Rat Human +DTXSID4045559 TK.Half.Life NA 2.326 hours 1compartment NA NA Rat Human +DTXSID4045559 Css NA 0.006232 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045559 Css NA 0.0274 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045559 Css NA 0.004068 mg/L PBTK NA 50% Rat Human +DTXSID4045559 Css NA 0.01624 mg/L PBTK NA 95% Rat Human +DTXSID4045630 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045630 Fup 0.947 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045630 Vd NA 1.662 L/kg 1compartment NA NA Human Human +DTXSID4045630 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4045630 TK.Half.Life NA 11.36 hours 1compartment NA NA Human Human +DTXSID4045630 Css NA 0.7207 mg/L 3compartmentss NA 50% Human Human +DTXSID4045630 Css NA 2.771 mg/L 3compartmentss NA 95% Human Human +DTXSID4045630 Css NA 0.6952 mg/L PBTK NA 50% Human Human +DTXSID4045630 Css NA 2.102 mg/L PBTK NA 95% Human Human +DTXSID4045630 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045630 Fup 0.947 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045630 Vd NA 1.699 L/kg 1compartment NA NA Rat Human DTXSID4045630 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045630 TK.Half.Life NA 2.406 hours 1compartment NA NA Rat Human -DTXSID4045630 Css NA 0.1379 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045630 Css NA 0.8887 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045630 Css NA 0.1266 mg/L PBTK NA 50% Rat Human -DTXSID4045630 Css NA 0.556 mg/L PBTK NA 95% Rat Human -DTXSID4045632 Clint NA 17.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045632 Fup NA 0.8748 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045632 Vd NA 5.534 L/kg 1compartment NA NA Human Human +DTXSID4045630 TK.Half.Life NA 3.956 hours 1compartment NA NA Rat Human +DTXSID4045630 Css NA 0.04216 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045630 Css NA 0.1514 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045630 Css NA 0.04194 mg/L PBTK NA 50% Rat Human +DTXSID4045630 Css NA 0.1101 mg/L PBTK NA 95% Rat Human +DTXSID4045632 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045632 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045632 Vd NA 1.025 L/kg 1compartment NA NA Human Human DTXSID4045632 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045632 TK.Half.Life NA 5.161 hours 1compartment NA NA Human Human -DTXSID4045632 Css NA 0.03932 mg/L 3compartmentss NA 50% Human Human -DTXSID4045632 Css NA 0.3334 mg/L 3compartmentss NA 95% Human Human -DTXSID4045632 Css NA 0.05216 mg/L PBTK NA 50% Human Human -DTXSID4045632 Css NA 0.3456 mg/L PBTK NA 95% Human Human -DTXSID4045632 Clint NA 17.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045632 Fup NA 0.8748 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045632 Vd NA 5.208 L/kg 1compartment NA NA Rat Human +DTXSID4045632 TK.Half.Life NA 2.613 hours 1compartment NA NA Human Human +DTXSID4045632 Css NA 0.2126 mg/L 3compartmentss NA 50% Human Human +DTXSID4045632 Css NA 1.403 mg/L 3compartmentss NA 95% Human Human +DTXSID4045632 Css NA 0.1624 mg/L PBTK NA 50% Human Human +DTXSID4045632 Css NA 0.949 mg/L PBTK NA 95% Human Human +DTXSID4045632 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045632 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045632 Vd NA 1.03 L/kg 1compartment NA NA Rat Human DTXSID4045632 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045632 TK.Half.Life NA 1.743 hours 1compartment NA NA Rat Human -DTXSID4045632 Css NA 0.0203 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045632 Css NA 0.1426 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045632 Css NA 0.0273 mg/L PBTK NA 50% Rat Human -DTXSID4045632 Css NA 0.1503 mg/L PBTK NA 95% Rat Human -DTXSID4045636 Clint NA 4.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045636 Fup NA 0.0452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045636 Vd NA 0.3175 L/kg 1compartment NA NA Human Human +DTXSID4045632 TK.Half.Life NA 1.515 hours 1compartment NA NA Rat Human +DTXSID4045632 Css NA 0.02504 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045632 Css NA 0.1219 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045632 Css NA 0.01907 mg/L PBTK NA 50% Rat Human +DTXSID4045632 Css NA 0.08043 mg/L PBTK NA 95% Rat Human +DTXSID4045636 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045636 Fup 0.0441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045636 Vd NA 0.3217 L/kg 1compartment NA NA Human Human DTXSID4045636 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045636 TK.Half.Life NA 6.07 hours 1compartment NA NA Human Human -DTXSID4045636 Css NA 3.254 mg/L 3compartmentss NA 50% Human Human -DTXSID4045636 Css NA 20.34 mg/L 3compartmentss NA 95% Human Human -DTXSID4045636 Css NA 2.008 mg/L PBTK NA 50% Human Human -DTXSID4045636 Css NA 12.05 mg/L PBTK NA 95% Human Human -DTXSID4045636 Clint NA 4.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045636 Fup NA 0.0452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045636 Vd NA 0.3011 L/kg 1compartment NA NA Rat Human +DTXSID4045636 TK.Half.Life NA 1.541 hours 1compartment NA NA Human Human +DTXSID4045636 Css NA 0.6016 mg/L 3compartmentss NA 50% Human Human +DTXSID4045636 Css NA 5.562 mg/L 3compartmentss NA 95% Human Human +DTXSID4045636 Css NA 0.371 mg/L PBTK NA 50% Human Human +DTXSID4045636 Css NA 3.313 mg/L PBTK NA 95% Human Human +DTXSID4045636 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045636 Fup 0.0441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045636 Vd NA 0.3041 L/kg 1compartment NA NA Rat Human DTXSID4045636 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045636 TK.Half.Life NA 3.494 hours 1compartment NA NA Rat Human -DTXSID4045636 Css NA 1.659 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045636 Css NA 7.615 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045636 Css NA 0.9582 mg/L PBTK NA 50% Rat Human -DTXSID4045636 Css NA 4.211 mg/L PBTK NA 95% Rat Human -DTXSID4045638 Clint NA 281.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045638 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045638 Vd NA 2.586 L/kg 1compartment NA NA Human Human +DTXSID4045636 TK.Half.Life NA 0.9216 hours 1compartment NA NA Rat Human +DTXSID4045636 Css NA 0.02894 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045636 Css NA 0.2949 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045636 Css NA 0.01716 mg/L PBTK NA 50% Rat Human +DTXSID4045636 Css NA 0.1671 mg/L PBTK NA 95% Rat Human +DTXSID4045638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045638 Fup 0.0613 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045638 Vd NA 3.45 L/kg 1compartment NA NA Human Human DTXSID4045638 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045638 TK.Half.Life NA 2.089 hours 1compartment NA NA Human Human -DTXSID4045638 Css NA 0.0168 mg/L 3compartmentss NA 50% Human Human -DTXSID4045638 Css NA 0.1385 mg/L 3compartmentss NA 95% Human Human -DTXSID4045638 Css NA 0.0132 mg/L PBTK NA 50% Human Human -DTXSID4045638 Css NA 0.09608 mg/L PBTK NA 95% Human Human -DTXSID4045638 Clint NA 281.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045638 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045638 Vd NA 2.332 L/kg 1compartment NA NA Rat Human +DTXSID4045638 TK.Half.Life NA 6.284 hours 1compartment NA NA Human Human +DTXSID4045638 Css NA 0.129 mg/L 3compartmentss NA 50% Human Human +DTXSID4045638 Css NA 0.9187 mg/L 3compartmentss NA 95% Human Human +DTXSID4045638 Css NA 0.1013 mg/L PBTK NA 50% Human Human +DTXSID4045638 Css NA 0.678 mg/L PBTK NA 95% Human Human +DTXSID4045638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045638 Fup 0.0613 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045638 Vd NA 2.824 L/kg 1compartment NA NA Rat Human DTXSID4045638 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045638 TK.Half.Life NA 0.8575 hours 1compartment NA NA Rat Human -DTXSID4045638 Css NA 0.0096 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045638 Css NA 0.06665 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045638 Css NA 0.007164 mg/L PBTK NA 50% Rat Human -DTXSID4045638 Css NA 0.04539 mg/L PBTK NA 95% Rat Human -DTXSID4045680 Clint NA 1.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045680 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045680 Vd NA 0.1914 L/kg 1compartment NA NA Human Human -DTXSID4045680 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID4045680 TK.Half.Life NA 34.43 hours 1compartment NA NA Human Human -DTXSID4045680 Css NA 32.3 mg/L 3compartmentss NA 50% Human Human -DTXSID4045680 Css NA 229.7 mg/L 3compartmentss NA 95% Human Human -DTXSID4045680 Css NA 18.91 mg/L PBTK NA 50% Human Human -DTXSID4045680 Css NA 132.3 mg/L PBTK NA 95% Human Human -DTXSID4045680 Clint NA 1.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045680 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045680 Vd NA 0.1882 L/kg 1compartment NA NA Rat Human -DTXSID4045680 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4045680 TK.Half.Life NA 17.99 hours 1compartment NA NA Rat Human -DTXSID4045680 Css NA 14.24 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045680 Css NA 84.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045680 Css NA 7.769 mg/L PBTK NA 50% Rat Human -DTXSID4045680 Css NA 45.86 mg/L PBTK NA 95% Rat Human -DTXSID4045682 Clint NA 16.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045682 Fup NA 0.2386 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045682 Vd NA 1.623 L/kg 1compartment NA NA Human Human +DTXSID4045638 TK.Half.Life NA 1.698 hours 1compartment NA NA Rat Human +DTXSID4045638 Css NA 0.01661 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045638 Css NA 0.09881 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045638 Css NA 0.01309 mg/L PBTK NA 50% Rat Human +DTXSID4045638 Css NA 0.0754 mg/L PBTK NA 95% Rat Human +DTXSID4045680 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045680 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045680 Vd NA 0.4556 L/kg 1compartment NA NA Human Human +DTXSID4045680 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4045680 TK.Half.Life NA 2.465 hours 1compartment NA NA Human Human +DTXSID4045680 Css NA 0.7088 mg/L 3compartmentss NA 50% Human Human +DTXSID4045680 Css NA 4.934 mg/L 3compartmentss NA 95% Human Human +DTXSID4045680 Css NA 0.4678 mg/L PBTK NA 50% Human Human +DTXSID4045680 Css NA 3.041 mg/L PBTK NA 95% Human Human +DTXSID4045680 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045680 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045680 Vd NA 0.4502 L/kg 1compartment NA NA Rat Human +DTXSID4045680 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4045680 TK.Half.Life NA 1.478 hours 1compartment NA NA Rat Human +DTXSID4045680 Css NA 0.08546 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045680 Css NA 0.4551 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045680 Css NA 0.05533 mg/L PBTK NA 50% Rat Human +DTXSID4045680 Css NA 0.2709 mg/L PBTK NA 95% Rat Human +DTXSID4045682 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045682 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045682 Vd NA 2.112 L/kg 1compartment NA NA Human Human DTXSID4045682 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045682 TK.Half.Life NA 2.485 hours 1compartment NA NA Human Human -DTXSID4045682 Css NA 0.09535 mg/L 3compartmentss NA 50% Human Human -DTXSID4045682 Css NA 0.7205 mg/L 3compartmentss NA 95% Human Human -DTXSID4045682 Css NA 0.08161 mg/L PBTK NA 50% Human Human -DTXSID4045682 Css NA 0.5315 mg/L PBTK NA 95% Human Human -DTXSID4045682 Clint NA 16.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045682 Fup NA 0.2386 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045682 Vd NA 1.609 L/kg 1compartment NA NA Rat Human +DTXSID4045682 TK.Half.Life NA 3.847 hours 1compartment NA NA Human Human +DTXSID4045682 Css NA 0.112 mg/L 3compartmentss NA 50% Human Human +DTXSID4045682 Css NA 0.8399 mg/L 3compartmentss NA 95% Human Human +DTXSID4045682 Css NA 0.1172 mg/L PBTK NA 50% Human Human +DTXSID4045682 Css NA 0.7187 mg/L PBTK NA 95% Human Human +DTXSID4045682 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045682 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045682 Vd NA 2.075 L/kg 1compartment NA NA Rat Human DTXSID4045682 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045682 TK.Half.Life NA 1.41 hours 1compartment NA NA Rat Human -DTXSID4045682 Css NA 0.05111 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045682 Css NA 0.2846 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045682 Css NA 0.04242 mg/L PBTK NA 50% Rat Human -DTXSID4045682 Css NA 0.2039 mg/L PBTK NA 95% Rat Human -DTXSID4045686 Clint NA 43.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045686 Fup NA 0.3548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045686 Vd NA 1.58 L/kg 1compartment NA NA Human Human +DTXSID4045682 TK.Half.Life NA 2.203 hours 1compartment NA NA Rat Human +DTXSID4045682 Css NA 0.013 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045682 Css NA 0.07511 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045682 Css NA 0.01398 mg/L PBTK NA 50% Rat Human +DTXSID4045682 Css NA 0.05942 mg/L PBTK NA 95% Rat Human +DTXSID4045686 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045686 Fup 0.574 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045686 Vd NA 1.265 L/kg 1compartment NA NA Human Human DTXSID4045686 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045686 TK.Half.Life NA 1.301 hours 1compartment NA NA Human Human -DTXSID4045686 Css NA 0.0242 mg/L 3compartmentss NA 50% Human Human -DTXSID4045686 Css NA 0.2025 mg/L 3compartmentss NA 95% Human Human -DTXSID4045686 Css NA 0.02168 mg/L PBTK NA 50% Human Human -DTXSID4045686 Css NA 0.1547 mg/L PBTK NA 95% Human Human -DTXSID4045686 Clint NA 43.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045686 Fup NA 0.3548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045686 Vd NA 1.558 L/kg 1compartment NA NA Rat Human +DTXSID4045686 TK.Half.Life NA 1.874 hours 1compartment NA NA Human Human +DTXSID4045686 Css NA 0.09041 mg/L 3compartmentss NA 50% Human Human +DTXSID4045686 Css NA 0.8859 mg/L 3compartmentss NA 95% Human Human +DTXSID4045686 Css NA 0.07861 mg/L PBTK NA 50% Human Human +DTXSID4045686 Css NA 0.5951 mg/L PBTK NA 95% Human Human +DTXSID4045686 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045686 Fup 0.574 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045686 Vd NA 1.259 L/kg 1compartment NA NA Rat Human DTXSID4045686 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045686 TK.Half.Life NA 0.6442 hours 1compartment NA NA Rat Human -DTXSID4045686 Css NA 0.01267 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045686 Css NA 0.08655 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045686 Css NA 0.01113 mg/L PBTK NA 50% Rat Human -DTXSID4045686 Css NA 0.06356 mg/L PBTK NA 95% Rat Human -DTXSID4045688 Clint NA 17.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045688 Fup NA 0.1766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4045686 TK.Half.Life NA 1.027 hours 1compartment NA NA Rat Human +DTXSID4045686 Css NA 0.004017 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045686 Css NA 0.04436 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045686 Css NA 0.003612 mg/L PBTK NA 50% Rat Human +DTXSID4045686 Css NA 0.02991 mg/L PBTK NA 95% Rat Human +DTXSID4045688 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045688 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4045688 Vd NA 1.065 L/kg 1compartment NA NA Human Human DTXSID4045688 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045688 TK.Half.Life NA 2.215 hours 1compartment NA NA Human Human -DTXSID4045688 Css NA 0.1746 mg/L 3compartmentss NA 50% Human Human -DTXSID4045688 Css NA 1.166 mg/L 3compartmentss NA 95% Human Human -DTXSID4045688 Css NA 0.1209 mg/L PBTK NA 50% Human Human -DTXSID4045688 Css NA 0.7623 mg/L PBTK NA 95% Human Human -DTXSID4045688 Clint NA 17.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045688 Fup NA 0.1766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045688 Vd NA 0.8651 L/kg 1compartment NA NA Rat Human +DTXSID4045688 TK.Half.Life NA 2.921 hours 1compartment NA NA Human Human +DTXSID4045688 Css NA 0.2451 mg/L 3compartmentss NA 50% Human Human +DTXSID4045688 Css NA 1.468 mg/L 3compartmentss NA 95% Human Human +DTXSID4045688 Css NA 0.1805 mg/L PBTK NA 50% Human Human +DTXSID4045688 Css NA 1.003 mg/L PBTK NA 95% Human Human +DTXSID4045688 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045688 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045688 Vd NA 0.9021 L/kg 1compartment NA NA Rat Human DTXSID4045688 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045688 TK.Half.Life NA 0.9734 hours 1compartment NA NA Rat Human -DTXSID4045688 Css NA 0.09442 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045688 Css NA 0.4585 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045688 Css NA 0.06223 mg/L PBTK NA 50% Rat Human -DTXSID4045688 Css NA 0.2862 mg/L PBTK NA 95% Rat Human -DTXSID4045711 Clint NA 17.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045711 Fup NA 0.0774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045711 Vd NA 2.494 L/kg 1compartment NA NA Human Human -DTXSID4045711 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045711 TK.Half.Life NA 9.324 hours 1compartment NA NA Human Human -DTXSID4045711 Css NA 0.423 mg/L 3compartmentss NA 50% Human Human -DTXSID4045711 Css NA 3.12 mg/L 3compartmentss NA 95% Human Human -DTXSID4045711 Css NA 0.3102 mg/L PBTK NA 50% Human Human -DTXSID4045711 Css NA 2.088 mg/L PBTK NA 95% Human Human -DTXSID4045711 Clint NA 17.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045711 Fup NA 0.0774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045711 Vd NA 2.08 L/kg 1compartment NA NA Rat Human -DTXSID4045711 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045711 TK.Half.Life NA 3.519 hours 1compartment NA NA Rat Human -DTXSID4045711 Css NA 0.2318 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045711 Css NA 1.308 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045711 Css NA 0.1636 mg/L PBTK NA 50% Rat Human -DTXSID4045711 Css NA 0.8541 mg/L PBTK NA 95% Rat Human -DTXSID4045763 Clint NA 5.799 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045763 Fup NA 0.733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045763 Vd NA 1.656 L/kg 1compartment NA NA Human Human -DTXSID4045763 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045763 TK.Half.Life NA 2.095 hours 1compartment NA NA Human Human -DTXSID4045763 Css NA 0.09254 mg/L 3compartmentss NA 50% Human Human -DTXSID4045763 Css NA 0.8381 mg/L 3compartmentss NA 95% Human Human -DTXSID4045763 Css NA 0.08606 mg/L PBTK NA 50% Human Human -DTXSID4045763 Css NA 0.6078 mg/L PBTK NA 95% Human Human -DTXSID4045763 Clint NA 5.799 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045763 Fup NA 0.733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045763 Vd NA 1.679 L/kg 1compartment NA NA Rat Human +DTXSID4045688 TK.Half.Life NA 1.346 hours 1compartment NA NA Rat Human +DTXSID4045688 Css NA 0.02864 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045688 Css NA 0.1297 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045688 Css NA 0.02095 mg/L PBTK NA 50% Rat Human +DTXSID4045688 Css NA 0.08454 mg/L PBTK NA 95% Rat Human +DTXSID4045711 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045711 Fup 0.0913 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045711 Vd NA 2.649 L/kg 1compartment NA NA Human Human +DTXSID4045711 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4045711 TK.Half.Life NA 21.75 hours 1compartment NA NA Human Human +DTXSID4045711 Css NA 0.9833 mg/L 3compartmentss NA 50% Human Human +DTXSID4045711 Css NA 6.199 mg/L 3compartmentss NA 95% Human Human +DTXSID4045711 Css NA 0.7399 mg/L PBTK NA 50% Human Human +DTXSID4045711 Css NA 4.233 mg/L PBTK NA 95% Human Human +DTXSID4045711 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045711 Fup 0.0913 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045711 Vd NA 2.214 L/kg 1compartment NA NA Rat Human +DTXSID4045711 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4045711 TK.Half.Life NA 7.65 hours 1compartment NA NA Rat Human +DTXSID4045711 Css NA 0.1202 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045711 Css NA 0.5864 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045711 Css NA 0.09016 mg/L PBTK NA 50% Rat Human +DTXSID4045711 Css NA 0.3891 mg/L PBTK NA 95% Rat Human +DTXSID4045763 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045763 Fup 0.711 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045763 Vd NA 1.31 L/kg 1compartment NA NA Human Human +DTXSID4045763 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4045763 TK.Half.Life NA 11.92 hours 1compartment NA NA Human Human +DTXSID4045763 Css NA 0.9384 mg/L 3compartmentss NA 50% Human Human +DTXSID4045763 Css NA 6.632 mg/L 3compartmentss NA 95% Human Human +DTXSID4045763 Css NA 0.8465 mg/L PBTK NA 50% Human Human +DTXSID4045763 Css NA 4.375 mg/L PBTK NA 95% Human Human +DTXSID4045763 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045763 Fup 0.711 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045763 Vd NA 1.337 L/kg 1compartment NA NA Rat Human DTXSID4045763 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045763 TK.Half.Life NA 1.153 hours 1compartment NA NA Rat Human -DTXSID4045763 Css NA 0.04303 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045763 Css NA 0.3568 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045763 Css NA 0.04018 mg/L PBTK NA 50% Rat Human -DTXSID4045763 Css NA 0.2285 mg/L PBTK NA 95% Rat Human -DTXSID4045765 Clint NA 0.7725 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045765 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045765 Vd NA 1.185 L/kg 1compartment NA NA Human Human +DTXSID4045763 TK.Half.Life NA 4.146 hours 1compartment NA NA Rat Human +DTXSID4045763 Css NA 0.05558 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045763 Css NA 0.3949 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045763 Css NA 0.0506 mg/L PBTK NA 50% Rat Human +DTXSID4045763 Css NA 0.2491 mg/L PBTK NA 95% Rat Human +DTXSID4045765 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045765 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045765 Vd NA 0.67 L/kg 1compartment NA NA Human Human DTXSID4045765 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045765 TK.Half.Life NA 3.575 hours 1compartment NA NA Human Human -DTXSID4045765 Css NA 0.3396 mg/L 3compartmentss NA 50% Human Human -DTXSID4045765 Css NA 2.363 mg/L 3compartmentss NA 95% Human Human -DTXSID4045765 Css NA 0.3052 mg/L PBTK NA 50% Human Human -DTXSID4045765 Css NA 1.641 mg/L PBTK NA 95% Human Human -DTXSID4045765 Clint NA 0.7725 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045765 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045765 Vd NA 1.207 L/kg 1compartment NA NA Rat Human +DTXSID4045765 TK.Half.Life NA 6.273 hours 1compartment NA NA Human Human +DTXSID4045765 Css NA 0.934 mg/L 3compartmentss NA 50% Human Human +DTXSID4045765 Css NA 6.154 mg/L 3compartmentss NA 95% Human Human +DTXSID4045765 Css NA 0.7558 mg/L PBTK NA 50% Human Human +DTXSID4045765 Css NA 3.969 mg/L PBTK NA 95% Human Human +DTXSID4045765 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045765 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045765 Vd NA 0.6957 L/kg 1compartment NA NA Rat Human DTXSID4045765 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045765 TK.Half.Life NA 1.685 hours 1compartment NA NA Rat Human -DTXSID4045765 Css NA 0.1212 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045765 Css NA 0.7839 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045765 Css NA 0.1084 mg/L PBTK NA 50% Rat Human -DTXSID4045765 Css NA 0.4903 mg/L PBTK NA 95% Rat Human -DTXSID4045767 Clint NA 9.345 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045767 Fup NA 0.0885 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045767 Vd NA 1.845 L/kg 1compartment NA NA Human Human +DTXSID4045765 TK.Half.Life NA 2.22 hours 1compartment NA NA Rat Human +DTXSID4045765 Css NA 0.01804 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045765 Css NA 0.1477 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045765 Css NA 0.01414 mg/L PBTK NA 50% Rat Human +DTXSID4045765 Css NA 0.09235 mg/L PBTK NA 95% Rat Human +DTXSID4045767 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045767 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045767 Vd NA 2.727 L/kg 1compartment NA NA Human Human DTXSID4045767 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045767 TK.Half.Life NA 7.658 hours 1compartment NA NA Human Human -DTXSID4045767 Css NA 0.4862 mg/L 3compartmentss NA 50% Human Human -DTXSID4045767 Css NA 3.954 mg/L 3compartmentss NA 95% Human Human -DTXSID4045767 Css NA 0.3758 mg/L PBTK NA 50% Human Human -DTXSID4045767 Css NA 2.682 mg/L PBTK NA 95% Human Human -DTXSID4045767 Clint NA 9.345 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045767 Fup NA 0.0885 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045767 Vd NA 1.827 L/kg 1compartment NA NA Rat Human +DTXSID4045767 TK.Half.Life NA 9.404 hours 1compartment NA NA Human Human +DTXSID4045767 Css NA 0.2961 mg/L 3compartmentss NA 50% Human Human +DTXSID4045767 Css NA 2.391 mg/L 3compartmentss NA 95% Human Human +DTXSID4045767 Css NA 0.2773 mg/L PBTK NA 50% Human Human +DTXSID4045767 Css NA 1.802 mg/L PBTK NA 95% Human Human +DTXSID4045767 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045767 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045767 Vd NA 2.728 L/kg 1compartment NA NA Rat Human DTXSID4045767 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045767 TK.Half.Life NA 4.687 hours 1compartment NA NA Rat Human -DTXSID4045767 Css NA 0.2627 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045767 Css NA 1.732 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045767 Css NA 0.1931 mg/L PBTK NA 50% Rat Human -DTXSID4045767 Css NA 1.064 mg/L PBTK NA 95% Rat Human -DTXSID4045769 Clint NA 0.7919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045769 Fup NA 0.0678 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045769 Vd NA 1.207 L/kg 1compartment NA NA Human Human -DTXSID4045769 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID4045769 TK.Half.Life NA 53.82 hours 1compartment NA NA Human Human -DTXSID4045769 Css NA 6.956 mg/L 3compartmentss NA 50% Human Human -DTXSID4045769 Css NA 32.87 mg/L 3compartmentss NA 95% Human Human -DTXSID4045769 Css NA 4.549 mg/L PBTK NA 50% Human Human -DTXSID4045769 Css NA 19.8 mg/L PBTK NA 95% Human Human -DTXSID4045769 Clint NA 0.7919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045769 Fup NA 0.0678 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045769 Vd NA 0.9903 L/kg 1compartment NA NA Rat Human -DTXSID4045769 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4045769 TK.Half.Life NA 19.42 hours 1compartment NA NA Rat Human -DTXSID4045769 Css NA 2.806 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045769 Css NA 11 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045769 Css NA 1.72 mg/L PBTK NA 50% Rat Human -DTXSID4045769 Css NA 6.176 mg/L PBTK NA 95% Rat Human -DTXSID4045846 Clint NA 15.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045846 Fup NA 0.1231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045846 Vd NA 0.256 L/kg 1compartment NA NA Human Human -DTXSID4045846 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045846 TK.Half.Life NA 0.7237 hours 1compartment NA NA Human Human -DTXSID4045846 Css NA 0.3318 mg/L 3compartmentss NA 50% Human Human -DTXSID4045846 Css NA 2.546 mg/L 3compartmentss NA 95% Human Human -DTXSID4045846 Css NA 0.2038 mg/L PBTK NA 50% Human Human -DTXSID4045846 Css NA 1.512 mg/L PBTK NA 95% Human Human -DTXSID4045846 Clint NA 15.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045846 Fup NA 0.1231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045846 Vd NA 0.2554 L/kg 1compartment NA NA Rat Human -DTXSID4045846 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045846 TK.Half.Life NA 0.4289 hours 1compartment NA NA Rat Human -DTXSID4045846 Css NA 0.1879 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045846 Css NA 1.036 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045846 Css NA 0.108 mg/L PBTK NA 50% Rat Human -DTXSID4045846 Css NA 0.58 mg/L PBTK NA 95% Rat Human -DTXSID4045848 Clint NA 4.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045848 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045848 Vd NA 0.6909 L/kg 1compartment NA NA Human Human -DTXSID4045848 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045848 TK.Half.Life NA 0.8136 hours 1compartment NA NA Human Human -DTXSID4045848 Css NA 0.0995 mg/L 3compartmentss NA 50% Human Human -DTXSID4045848 Css NA 0.8882 mg/L 3compartmentss NA 95% Human Human -DTXSID4045848 Css NA 0.08038 mg/L PBTK NA 50% Human Human -DTXSID4045848 Css NA 0.619 mg/L PBTK NA 95% Human Human -DTXSID4045848 Clint NA 4.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045848 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045848 Vd NA 0.7426 L/kg 1compartment NA NA Rat Human -DTXSID4045848 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045848 TK.Half.Life NA 0.4539 hours 1compartment NA NA Rat Human -DTXSID4045848 Css NA 0.04608 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045848 Css NA 0.3236 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045848 Css NA 0.03703 mg/L PBTK NA 50% Rat Human -DTXSID4045848 Css NA 0.2044 mg/L PBTK NA 95% Rat Human -DTXSID4045890 Clint NA 13.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045890 Fup NA 0.7951 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045890 Vd NA 0.6339 L/kg 1compartment NA NA Human Human +DTXSID4045767 TK.Half.Life NA 5.626 hours 1compartment NA NA Rat Human +DTXSID4045767 Css NA 0.03535 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045767 Css NA 0.2125 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045767 Css NA 0.03368 mg/L PBTK NA 50% Rat Human +DTXSID4045767 Css NA 0.1581 mg/L PBTK NA 95% Rat Human +DTXSID4045769 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045769 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045769 Vd NA 2.226 L/kg 1compartment NA NA Human Human +DTXSID4045769 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4045769 TK.Half.Life NA 7.16 hours 1compartment NA NA Human Human +DTXSID4045769 Css NA 0.2756 mg/L 3compartmentss NA 50% Human Human +DTXSID4045769 Css NA 1.675 mg/L 3compartmentss NA 95% Human Human +DTXSID4045769 Css NA 0.225 mg/L PBTK NA 50% Human Human +DTXSID4045769 Css NA 1.236 mg/L PBTK NA 95% Human Human +DTXSID4045769 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045769 Fup 0.287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045769 Vd NA 1.893 L/kg 1compartment NA NA Rat Human +DTXSID4045769 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4045769 TK.Half.Life NA 2.845 hours 1compartment NA NA Rat Human +DTXSID4045769 Css NA 0.03271 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045769 Css NA 0.139 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045769 Css NA 0.02697 mg/L PBTK NA 50% Rat Human +DTXSID4045769 Css NA 0.09952 mg/L PBTK NA 95% Rat Human +DTXSID4045890 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045890 Fup 0.821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045890 Vd NA 0.6406 L/kg 1compartment NA NA Human Human DTXSID4045890 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045890 TK.Half.Life NA 0.5919 hours 1compartment NA NA Human Human -DTXSID4045890 Css NA 0.04889 mg/L 3compartmentss NA 50% Human Human -DTXSID4045890 Css NA 0.4231 mg/L 3compartmentss NA 95% Human Human -DTXSID4045890 Css NA 0.03824 mg/L PBTK NA 50% Human Human -DTXSID4045890 Css NA 0.2918 mg/L PBTK NA 95% Human Human -DTXSID4045890 Clint NA 13.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045890 Fup NA 0.7951 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045890 Vd NA 0.6588 L/kg 1compartment NA NA Rat Human +DTXSID4045890 TK.Half.Life NA 5.052 hours 1compartment NA NA Human Human +DTXSID4045890 Css NA 0.5574 mg/L 3compartmentss NA 50% Human Human +DTXSID4045890 Css NA 3.419 mg/L 3compartmentss NA 95% Human Human +DTXSID4045890 Css NA 0.4429 mg/L PBTK NA 50% Human Human +DTXSID4045890 Css NA 2.181 mg/L PBTK NA 95% Human Human +DTXSID4045890 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045890 Fup 0.821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045890 Vd NA 0.6668 L/kg 1compartment NA NA Rat Human DTXSID4045890 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045890 TK.Half.Life NA 0.3077 hours 1compartment NA NA Rat Human -DTXSID4045890 Css NA 0.02411 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045890 Css NA 0.1991 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045890 Css NA 0.01847 mg/L PBTK NA 50% Rat Human -DTXSID4045890 Css NA 0.1237 mg/L PBTK NA 95% Rat Human -DTXSID4045892 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045892 Fup NA 0.224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045892 Vd NA 0.9909 L/kg 1compartment NA NA Human Human +DTXSID4045890 TK.Half.Life NA 1.792 hours 1compartment NA NA Rat Human +DTXSID4045890 Css NA 0.002867 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045890 Css NA 0.01838 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045890 Css NA 0.002209 mg/L PBTK NA 50% Rat Human +DTXSID4045890 Css NA 0.01123 mg/L PBTK NA 95% Rat Human +DTXSID4045892 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045892 Fup 0.218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045892 Vd NA 0.9779 L/kg 1compartment NA NA Human Human DTXSID4045892 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4045892 TK.Half.Life NA 28.63 hours 1compartment NA NA Human Human -DTXSID4045892 Css NA 3.195 mg/L 3compartmentss NA 50% Human Human -DTXSID4045892 Css NA 12.38 mg/L 3compartmentss NA 95% Human Human -DTXSID4045892 Css NA 2.371 mg/L PBTK NA 50% Human Human -DTXSID4045892 Css NA 8.082 mg/L PBTK NA 95% Human Human -DTXSID4045892 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045892 Fup NA 0.224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045892 Vd NA 0.9911 L/kg 1compartment NA NA Rat Human +DTXSID4045892 TK.Half.Life NA 29.03 hours 1compartment NA NA Human Human +DTXSID4045892 Css NA 2.778 mg/L 3compartmentss NA 50% Human Human +DTXSID4045892 Css NA 11.31 mg/L 3compartmentss NA 95% Human Human +DTXSID4045892 Css NA 2.054 mg/L PBTK NA 50% Human Human +DTXSID4045892 Css NA 7.238 mg/L PBTK NA 95% Human Human +DTXSID4045892 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045892 Fup 0.218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045892 Vd NA 0.9777 L/kg 1compartment NA NA Rat Human DTXSID4045892 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4045892 TK.Half.Life NA 9.756 hours 1compartment NA NA Rat Human -DTXSID4045892 Css NA 0.8801 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045892 Css NA 2.898 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045892 Css NA 0.6214 mg/L PBTK NA 50% Rat Human -DTXSID4045892 Css NA 1.737 mg/L PBTK NA 95% Rat Human -DTXSID4045896 Clint NA 49.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045896 Fup NA 0.1056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045896 Vd NA 2.049 L/kg 1compartment NA NA Human Human +DTXSID4045892 TK.Half.Life NA 9.889 hours 1compartment NA NA Rat Human +DTXSID4045892 Css NA 0.06712 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045892 Css NA 0.3692 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045892 Css NA 0.04907 mg/L PBTK NA 50% Rat Human +DTXSID4045892 Css NA 0.2373 mg/L PBTK NA 95% Rat Human +DTXSID4045896 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045896 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045896 Vd NA 2.278 L/kg 1compartment NA NA Human Human DTXSID4045896 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045896 TK.Half.Life NA 3.881 hours 1compartment NA NA Human Human -DTXSID4045896 Css NA 0.1618 mg/L 3compartmentss NA 50% Human Human -DTXSID4045896 Css NA 1.213 mg/L 3compartmentss NA 95% Human Human -DTXSID4045896 Css NA 0.1101 mg/L PBTK NA 50% Human Human -DTXSID4045896 Css NA 0.7779 mg/L PBTK NA 95% Human Human -DTXSID4045896 Clint NA 49.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045896 Fup NA 0.1056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045896 Vd NA 1.551 L/kg 1compartment NA NA Rat Human +DTXSID4045896 TK.Half.Life NA 7.097 hours 1compartment NA NA Human Human +DTXSID4045896 Css NA 0.3152 mg/L 3compartmentss NA 50% Human Human +DTXSID4045896 Css NA 2.115 mg/L 3compartmentss NA 95% Human Human +DTXSID4045896 Css NA 0.2184 mg/L PBTK NA 50% Human Human +DTXSID4045896 Css NA 1.405 mg/L PBTK NA 95% Human Human +DTXSID4045896 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045896 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045896 Vd NA 1.727 L/kg 1compartment NA NA Rat Human DTXSID4045896 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045896 TK.Half.Life NA 1.277 hours 1compartment NA NA Rat Human -DTXSID4045896 Css NA 0.09005 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045896 Css NA 0.5252 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045896 Css NA 0.05816 mg/L PBTK NA 50% Rat Human -DTXSID4045896 Css NA 0.3239 mg/L PBTK NA 95% Rat Human -DTXSID4045898 Clint NA 16.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045898 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045898 Vd NA 0.3573 L/kg 1compartment NA NA Human Human +DTXSID4045896 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human +DTXSID4045896 Css NA 0.04076 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045896 Css NA 0.2141 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045896 Css NA 0.02796 mg/L PBTK NA 50% Rat Human +DTXSID4045896 Css NA 0.1427 mg/L PBTK NA 95% Rat Human +DTXSID4045898 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045898 Fup 0.0686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045898 Vd NA 0.55 L/kg 1compartment NA NA Human Human DTXSID4045898 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045898 TK.Half.Life NA 2.707 hours 1compartment NA NA Human Human -DTXSID4045898 Css NA 1.296 mg/L 3compartmentss NA 50% Human Human -DTXSID4045898 Css NA 10.76 mg/L 3compartmentss NA 95% Human Human -DTXSID4045898 Css NA 0.774 mg/L PBTK NA 50% Human Human -DTXSID4045898 Css NA 6.29 mg/L PBTK NA 95% Human Human -DTXSID4045898 Clint NA 16.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045898 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045898 Vd NA 0.303 L/kg 1compartment NA NA Rat Human +DTXSID4045898 TK.Half.Life NA 1.85 hours 1compartment NA NA Human Human +DTXSID4045898 Css NA 0.4338 mg/L 3compartmentss NA 50% Human Human +DTXSID4045898 Css NA 3.517 mg/L 3compartmentss NA 95% Human Human +DTXSID4045898 Css NA 0.268 mg/L PBTK NA 50% Human Human +DTXSID4045898 Css NA 2.131 mg/L PBTK NA 95% Human Human +DTXSID4045898 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045898 Fup 0.0686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045898 Vd NA 0.4526 L/kg 1compartment NA NA Rat Human DTXSID4045898 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045898 TK.Half.Life NA 1.47 hours 1compartment NA NA Rat Human -DTXSID4045898 Css NA 0.7372 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045898 Css NA 4.576 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045898 Css NA 0.4095 mg/L PBTK NA 50% Rat Human -DTXSID4045898 Css NA 2.499 mg/L PBTK NA 95% Rat Human -DTXSID4045921 Clint NA 5.366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045921 Fup NA 0.4262 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045921 Vd NA 2.377 L/kg 1compartment NA NA Human Human +DTXSID4045898 TK.Half.Life NA 0.9143 hours 1compartment NA NA Rat Human +DTXSID4045898 Css NA 0.05726 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045898 Css NA 0.3567 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045898 Css NA 0.0342 mg/L PBTK NA 50% Rat Human +DTXSID4045898 Css NA 0.2082 mg/L PBTK NA 95% Rat Human +DTXSID4045921 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045921 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045921 Vd NA 0.8092 L/kg 1compartment NA NA Human Human DTXSID4045921 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045921 TK.Half.Life NA 8.445 hours 1compartment NA NA Human Human -DTXSID4045921 Css NA 0.3364 mg/L 3compartmentss NA 50% Human Human -DTXSID4045921 Css NA 1.829 mg/L 3compartmentss NA 95% Human Human -DTXSID4045921 Css NA 0.2668 mg/L PBTK NA 50% Human Human -DTXSID4045921 Css NA 1.326 mg/L PBTK NA 95% Human Human -DTXSID4045921 Clint NA 5.366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045921 Fup NA 0.4262 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045921 Vd NA 1.86 L/kg 1compartment NA NA Rat Human +DTXSID4045921 TK.Half.Life NA 1.592 hours 1compartment NA NA Human Human +DTXSID4045921 Css NA 0.1256 mg/L 3compartmentss NA 50% Human Human +DTXSID4045921 Css NA 0.8883 mg/L 3compartmentss NA 95% Human Human +DTXSID4045921 Css NA 0.1052 mg/L PBTK NA 50% Human Human +DTXSID4045921 Css NA 0.6364 mg/L PBTK NA 95% Human Human +DTXSID4045921 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045921 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045921 Vd NA 0.8105 L/kg 1compartment NA NA Rat Human DTXSID4045921 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045921 TK.Half.Life NA 2.454 hours 1compartment NA NA Rat Human -DTXSID4045921 Css NA 0.1685 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045921 Css NA 0.6609 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045921 Css NA 0.1296 mg/L PBTK NA 50% Rat Human -DTXSID4045921 Css NA 0.454 mg/L PBTK NA 95% Rat Human -DTXSID4045925 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045925 Fup NA 0.7644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045925 Vd NA 0.4417 L/kg 1compartment NA NA Human Human +DTXSID4045921 TK.Half.Life NA 0.9034 hours 1compartment NA NA Rat Human +DTXSID4045921 Css NA 0.005413 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045921 Css NA 0.04611 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045921 Css NA 0.004626 mg/L PBTK NA 50% Rat Human +DTXSID4045921 Css NA 0.03226 mg/L PBTK NA 95% Rat Human +DTXSID4045925 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045925 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045925 Vd NA 0.2896 L/kg 1compartment NA NA Human Human DTXSID4045925 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045925 TK.Half.Life NA 3.739 hours 1compartment NA NA Human Human -DTXSID4045925 Css NA 1.148 mg/L 3compartmentss NA 50% Human Human -DTXSID4045925 Css NA 6.452 mg/L 3compartmentss NA 95% Human Human -DTXSID4045925 Css NA 0.839 mg/L PBTK NA 50% Human Human -DTXSID4045925 Css NA 3.994 mg/L PBTK NA 95% Human Human -DTXSID4045925 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045925 Fup NA 0.7644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045925 Vd NA 0.4617 L/kg 1compartment NA NA Rat Human +DTXSID4045925 TK.Half.Life NA 6.006 hours 1compartment NA NA Human Human +DTXSID4045925 Css NA 0.8826 mg/L 3compartmentss NA 50% Human Human +DTXSID4045925 Css NA 3.789 mg/L 3compartmentss NA 95% Human Human +DTXSID4045925 Css NA 0.579 mg/L PBTK NA 50% Human Human +DTXSID4045925 Css NA 2.309 mg/L PBTK NA 95% Human Human +DTXSID4045925 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045925 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045925 Vd NA 0.2999 L/kg 1compartment NA NA Rat Human DTXSID4045925 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045925 TK.Half.Life NA 1.332 hours 1compartment NA NA Rat Human -DTXSID4045925 Css NA 0.2988 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045925 Css NA 1.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045925 Css NA 0.2086 mg/L PBTK NA 50% Rat Human -DTXSID4045925 Css NA 0.9752 mg/L PBTK NA 95% Rat Human -DTXSID4045927 Clint NA 2.171 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045927 Fup NA 0.0711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045927 Vd NA 3.268 L/kg 1compartment NA NA Human Human -DTXSID4045927 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID4045927 TK.Half.Life NA 94.54 hours 1compartment NA NA Human Human -DTXSID4045927 Css NA 3.352 mg/L 3compartmentss NA 50% Human Human -DTXSID4045927 Css NA 21.22 mg/L 3compartmentss NA 95% Human Human -DTXSID4045927 Css NA 2.448 mg/L PBTK NA 50% Human Human -DTXSID4045927 Css NA 14.71 mg/L PBTK NA 95% Human Human -DTXSID4045927 Clint NA 2.171 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045927 Fup NA 0.0711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045927 Vd NA 2.525 L/kg 1compartment NA NA Rat Human -DTXSID4045927 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID4045927 TK.Half.Life NA 14.25 hours 1compartment NA NA Rat Human -DTXSID4045927 Css NA 1.854 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045927 Css NA 9.243 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045927 Css NA 1.298 mg/L PBTK NA 50% Rat Human -DTXSID4045927 Css NA 6.176 mg/L PBTK NA 95% Rat Human -DTXSID4045929 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045929 Fup NA 0.3567 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045929 Vd NA 0.7463 L/kg 1compartment NA NA Human Human +DTXSID4045925 TK.Half.Life NA 2.119 hours 1compartment NA NA Rat Human +DTXSID4045925 Css NA 0.003997 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045925 Css NA 0.01457 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045925 Css NA 0.002462 mg/L PBTK NA 50% Rat Human +DTXSID4045925 Css NA 0.008304 mg/L PBTK NA 95% Rat Human +DTXSID4045927 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045927 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045927 Vd NA 3.306 L/kg 1compartment NA NA Human Human +DTXSID4045927 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4045927 TK.Half.Life NA 11.81 hours 1compartment NA NA Human Human +DTXSID4045927 Css NA 0.3224 mg/L 3compartmentss NA 50% Human Human +DTXSID4045927 Css NA 2.17 mg/L 3compartmentss NA 95% Human Human +DTXSID4045927 Css NA 0.2363 mg/L PBTK NA 50% Human Human +DTXSID4045927 Css NA 1.517 mg/L PBTK NA 95% Human Human +DTXSID4045927 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045927 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045927 Vd NA 2.557 L/kg 1compartment NA NA Rat Human +DTXSID4045927 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4045927 TK.Half.Life NA 2.176 hours 1compartment NA NA Rat Human +DTXSID4045927 Css NA 0.0418 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045927 Css NA 0.2466 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045927 Css NA 0.03042 mg/L PBTK NA 50% Rat Human +DTXSID4045927 Css NA 0.1754 mg/L PBTK NA 95% Rat Human +DTXSID4045929 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045929 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045929 Vd NA 0.5449 L/kg 1compartment NA NA Human Human DTXSID4045929 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4045929 TK.Half.Life NA 13.62 hours 1compartment NA NA Human Human -DTXSID4045929 Css NA 2.015 mg/L 3compartmentss NA 50% Human Human -DTXSID4045929 Css NA 8.447 mg/L 3compartmentss NA 95% Human Human -DTXSID4045929 Css NA 1.502 mg/L PBTK NA 50% Human Human -DTXSID4045929 Css NA 5.39 mg/L PBTK NA 95% Human Human -DTXSID4045929 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045929 Fup NA 0.3567 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045929 Vd NA 0.7365 L/kg 1compartment NA NA Rat Human +DTXSID4045929 TK.Half.Life NA 12 hours 1compartment NA NA Human Human +DTXSID4045929 Css NA 2.195 mg/L 3compartmentss NA 50% Human Human +DTXSID4045929 Css NA 8.706 mg/L 3compartmentss NA 95% Human Human +DTXSID4045929 Css NA 1.545 mg/L PBTK NA 50% Human Human +DTXSID4045929 Css NA 5.455 mg/L PBTK NA 95% Human Human +DTXSID4045929 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045929 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045929 Vd NA 0.5503 L/kg 1compartment NA NA Rat Human DTXSID4045929 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045929 TK.Half.Life NA 4.557 hours 1compartment NA NA Rat Human -DTXSID4045929 Css NA 0.5508 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045929 Css NA 1.966 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045929 Css NA 0.3932 mg/L PBTK NA 50% Rat Human -DTXSID4045929 Css NA 1.176 mg/L PBTK NA 95% Rat Human -DTXSID4045973 Clint NA 10.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045973 Fup NA 0.0965 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045973 Vd NA 1.668 L/kg 1compartment NA NA Human Human +DTXSID4045929 TK.Half.Life NA 4.128 hours 1compartment NA NA Rat Human +DTXSID4045929 Css NA 0.03933 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045929 Css NA 0.2429 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045929 Css NA 0.02647 mg/L PBTK NA 50% Rat Human +DTXSID4045929 Css NA 0.1494 mg/L PBTK NA 95% Rat Human +DTXSID4045973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045973 Fup 0.0703 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045973 Vd NA 1.471 L/kg 1compartment NA NA Human Human DTXSID4045973 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045973 TK.Half.Life NA 8.576 hours 1compartment NA NA Human Human -DTXSID4045973 Css NA 0.674 mg/L 3compartmentss NA 50% Human Human -DTXSID4045973 Css NA 4.515 mg/L 3compartmentss NA 95% Human Human -DTXSID4045973 Css NA 0.4475 mg/L PBTK NA 50% Human Human -DTXSID4045973 Css NA 2.848 mg/L PBTK NA 95% Human Human -DTXSID4045973 Clint NA 10.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045973 Fup NA 0.0965 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045973 Vd NA 1.27 L/kg 1compartment NA NA Rat Human +DTXSID4045973 TK.Half.Life NA 5.348 hours 1compartment NA NA Human Human +DTXSID4045973 Css NA 0.4331 mg/L 3compartmentss NA 50% Human Human +DTXSID4045973 Css NA 3.208 mg/L 3compartmentss NA 95% Human Human +DTXSID4045973 Css NA 0.2812 mg/L PBTK NA 50% Human Human +DTXSID4045973 Css NA 2.031 mg/L PBTK NA 95% Human Human +DTXSID4045973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045973 Fup 0.0703 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045973 Vd NA 1.115 L/kg 1compartment NA NA Rat Human DTXSID4045973 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045973 TK.Half.Life NA 3.164 hours 1compartment NA NA Rat Human -DTXSID4045973 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045973 Css NA 1.829 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045973 Css NA 0.2302 mg/L PBTK NA 50% Rat Human -DTXSID4045973 Css NA 1.091 mg/L PBTK NA 95% Rat Human -DTXSID4045975 Clint NA 29.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045975 Fup NA 0.0194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045975 Vd NA 1.821 L/kg 1compartment NA NA Human Human -DTXSID4045975 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4045975 TK.Half.Life NA 13.93 hours 1compartment NA NA Human Human -DTXSID4045975 Css NA 1.162 mg/L 3compartmentss NA 50% Human Human -DTXSID4045975 Css NA 9.739 mg/L 3compartmentss NA 95% Human Human -DTXSID4045975 Css NA 0.7352 mg/L PBTK NA 50% Human Human -DTXSID4045975 Css NA 5.891 mg/L PBTK NA 95% Human Human -DTXSID4045975 Clint NA 29.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045975 Fup NA 0.0194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045975 Vd NA 1.352 L/kg 1compartment NA NA Rat Human -DTXSID4045975 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045975 TK.Half.Life NA 4.82 hours 1compartment NA NA Rat Human -DTXSID4045975 Css NA 0.6438 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045975 Css NA 4.439 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045975 Css NA 0.3869 mg/L PBTK NA 50% Rat Human -DTXSID4045975 Css NA 2.538 mg/L PBTK NA 95% Rat Human +DTXSID4045973 TK.Half.Life NA 2.083 hours 1compartment NA NA Rat Human +DTXSID4045973 Css NA 0.05636 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045973 Css NA 0.3242 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045973 Css NA 0.03574 mg/L PBTK NA 50% Rat Human +DTXSID4045973 Css NA 0.1981 mg/L PBTK NA 95% Rat Human +DTXSID4045975 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045975 Fup 0.0308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4045975 Vd NA 2.523 L/kg 1compartment NA NA Human Human +DTXSID4045975 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID4045975 TK.Half.Life NA 78.42 hours 1compartment NA NA Human Human +DTXSID4045975 Css NA 4.428 mg/L 3compartmentss NA 50% Human Human +DTXSID4045975 Css NA 28.27 mg/L 3compartmentss NA 95% Human Human +DTXSID4045975 Css NA 2.948 mg/L PBTK NA 50% Human Human +DTXSID4045975 Css NA 17.88 mg/L PBTK NA 95% Human Human +DTXSID4045975 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045975 Fup 0.0308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4045975 Vd NA 1.886 L/kg 1compartment NA NA Rat Human +DTXSID4045975 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID4045975 TK.Half.Life NA 18.33 hours 1compartment NA NA Rat Human +DTXSID4045975 Css NA 0.5539 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045975 Css NA 2.742 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045975 Css NA 0.3637 mg/L PBTK NA 50% Rat Human +DTXSID4045975 Css NA 1.713 mg/L PBTK NA 95% Rat Human DTXSID4045979 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4045979 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4045979 Vd NA 0.8126 L/kg 1compartment NA NA Human Human +DTXSID4045979 Vd NA 0.8053 L/kg 1compartment NA NA Human Human DTXSID4045979 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4045979 TK.Half.Life NA 5.259 hours 1compartment NA NA Human Human -DTXSID4045979 Css NA 0.8284 mg/L 3compartmentss NA 50% Human Human -DTXSID4045979 Css NA 5.553 mg/L 3compartmentss NA 95% Human Human -DTXSID4045979 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID4045979 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID4045979 TK.Half.Life NA 5.212 hours 1compartment NA NA Human Human +DTXSID4045979 Css NA 0.6996 mg/L 3compartmentss NA 50% Human Human +DTXSID4045979 Css NA 5.039 mg/L 3compartmentss NA 95% Human Human +DTXSID4045979 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID4045979 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID4045979 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4045979 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4045979 Vd NA 0.8621 L/kg 1compartment NA NA Rat Human +DTXSID4045979 Vd NA 0.8564 L/kg 1compartment NA NA Rat Human DTXSID4045979 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4045979 TK.Half.Life NA 1.901 hours 1compartment NA NA Rat Human -DTXSID4045979 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human -DTXSID4045979 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID4045979 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID4045979 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID4046020 Clint NA 13.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046020 Fup NA 0.706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046020 Vd NA 0.706 L/kg 1compartment NA NA Human Human +DTXSID4045979 TK.Half.Life NA 1.888 hours 1compartment NA NA Rat Human +DTXSID4045979 Css NA 0.01282 mg/L 3compartmentss NA 50% Rat Human +DTXSID4045979 Css NA 0.09947 mg/L 3compartmentss NA 95% Rat Human +DTXSID4045979 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID4045979 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID4046020 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046020 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046020 Vd NA 0.6479 L/kg 1compartment NA NA Human Human DTXSID4046020 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046020 TK.Half.Life NA 0.6802 hours 1compartment NA NA Human Human -DTXSID4046020 Css NA 0.04968 mg/L 3compartmentss NA 50% Human Human -DTXSID4046020 Css NA 0.4784 mg/L 3compartmentss NA 95% Human Human -DTXSID4046020 Css NA 0.03978 mg/L PBTK NA 50% Human Human -DTXSID4046020 Css NA 0.3226 mg/L PBTK NA 95% Human Human -DTXSID4046020 Clint NA 13.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046020 Fup NA 0.706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046020 Vd NA 0.7222 L/kg 1compartment NA NA Rat Human +DTXSID4046020 TK.Half.Life NA 6.911 hours 1compartment NA NA Human Human +DTXSID4046020 Css NA 1.201 mg/L 3compartmentss NA 50% Human Human +DTXSID4046020 Css NA 8.056 mg/L 3compartmentss NA 95% Human Human +DTXSID4046020 Css NA 0.945 mg/L PBTK NA 50% Human Human +DTXSID4046020 Css NA 5.126 mg/L PBTK NA 95% Human Human +DTXSID4046020 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046020 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046020 Vd NA 0.6622 L/kg 1compartment NA NA Rat Human DTXSID4046020 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046020 TK.Half.Life NA 0.352 hours 1compartment NA NA Rat Human -DTXSID4046020 Css NA 0.02471 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046020 Css NA 0.205 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046020 Css NA 0.0193 mg/L PBTK NA 50% Rat Human -DTXSID4046020 Css NA 0.1316 mg/L PBTK NA 95% Rat Human +DTXSID4046020 TK.Half.Life NA 2.403 hours 1compartment NA NA Rat Human +DTXSID4046020 Css NA 0.07289 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046020 Css NA 0.4647 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046020 Css NA 0.057 mg/L PBTK NA 50% Rat Human +DTXSID4046020 Css NA 0.281 mg/L PBTK NA 95% Rat Human DTXSID4046022 Clint 8 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID4046022 Fup 0.15 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID4046022 Vd NA 1.413 L/kg 1compartment NA NA Human Human DTXSID4046022 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4046022 TK.Half.Life NA 5.96 hours 1compartment NA NA Human Human -DTXSID4046022 Css NA 0.4981 mg/L 3compartmentss NA 50% Human Human -DTXSID4046022 Css NA 3.373 mg/L 3compartmentss NA 95% Human Human -DTXSID4046022 Css NA 0.3436 mg/L PBTK NA 50% Human Human -DTXSID4046022 Css NA 2.146 mg/L PBTK NA 95% Human Human +DTXSID4046022 Css NA 0.483 mg/L 3compartmentss NA 50% Human Human +DTXSID4046022 Css NA 3.214 mg/L 3compartmentss NA 95% Human Human +DTXSID4046022 Css NA 0.3296 mg/L PBTK NA 50% Human Human +DTXSID4046022 Css NA 2.051 mg/L PBTK NA 95% Human Human DTXSID4046022 Clint 10.21 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4046022 Fup 0.15 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID4046022 Vd NA 1.104 L/kg 1compartment NA NA Rat Rat DTXSID4046022 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID4046022 TK.Half.Life NA 2.018 hours 1compartment NA NA Rat Rat -DTXSID4046022 Css NA 0.2132 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4046022 Css NA 1.132 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4046022 Css NA 0.1386 mg/L PBTK NA 50% Rat Rat -DTXSID4046022 Css NA 0.6794 mg/L PBTK NA 95% Rat Rat -DTXSID4046024 Clint NA 16.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046024 Fup NA 0.031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046024 Vd NA 1.057 L/kg 1compartment NA NA Human Human +DTXSID4046022 Css NA 0.04782 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4046022 Css NA 0.2554 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4046022 Css NA 0.03239 mg/L PBTK NA 50% Rat Rat +DTXSID4046022 Css NA 0.1605 mg/L PBTK NA 95% Rat Rat +DTXSID4046024 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046024 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046024 Vd NA 0.3596 L/kg 1compartment NA NA Human Human DTXSID4046024 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046024 TK.Half.Life NA 8.606 hours 1compartment NA NA Human Human -DTXSID4046024 Css NA 1.308 mg/L 3compartmentss NA 50% Human Human -DTXSID4046024 Css NA 11.49 mg/L 3compartmentss NA 95% Human Human -DTXSID4046024 Css NA 0.8088 mg/L PBTK NA 50% Human Human -DTXSID4046024 Css NA 6.857 mg/L PBTK NA 95% Human Human -DTXSID4046024 Clint NA 16.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046024 Fup NA 0.031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046024 Vd NA 0.7941 L/kg 1compartment NA NA Rat Human +DTXSID4046024 TK.Half.Life NA 0.5115 hours 1compartment NA NA Human Human +DTXSID4046024 Css NA 0.0797 mg/L 3compartmentss NA 50% Human Human +DTXSID4046024 Css NA 0.5697 mg/L 3compartmentss NA 95% Human Human +DTXSID4046024 Css NA 0.0531 mg/L PBTK NA 50% Human Human +DTXSID4046024 Css NA 0.3639 mg/L PBTK NA 95% Human Human +DTXSID4046024 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046024 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046024 Vd NA 0.3775 L/kg 1compartment NA NA Rat Human DTXSID4046024 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046024 TK.Half.Life NA 3.735 hours 1compartment NA NA Rat Human -DTXSID4046024 Css NA 0.7344 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046024 Css NA 5.038 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046024 Css NA 0.4256 mg/L PBTK NA 50% Rat Human -DTXSID4046024 Css NA 2.811 mg/L PBTK NA 95% Rat Human -DTXSID4046076 Clint NA 13.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046076 Fup NA 0.1315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046076 Vd NA 2.068 L/kg 1compartment NA NA Human Human +DTXSID4046024 TK.Half.Life NA 0.2865 hours 1compartment NA NA Rat Human +DTXSID4046024 Css NA 0.01007 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046024 Css NA 0.05591 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046024 Css NA 0.006604 mg/L PBTK NA 50% Rat Human +DTXSID4046024 Css NA 0.03409 mg/L PBTK NA 95% Rat Human +DTXSID4046076 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046076 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046076 Vd NA 0.909 L/kg 1compartment NA NA Human Human DTXSID4046076 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046076 TK.Half.Life NA 5.082 hours 1compartment NA NA Human Human -DTXSID4046076 Css NA 0.2339 mg/L 3compartmentss NA 50% Human Human -DTXSID4046076 Css NA 1.956 mg/L 3compartmentss NA 95% Human Human -DTXSID4046076 Css NA 0.1935 mg/L PBTK NA 50% Human Human -DTXSID4046076 Css NA 1.372 mg/L PBTK NA 95% Human Human -DTXSID4046076 Clint NA 13.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046076 Fup NA 0.1315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046076 Vd NA 2.061 L/kg 1compartment NA NA Rat Human +DTXSID4046076 TK.Half.Life NA 2.259 hours 1compartment NA NA Human Human +DTXSID4046076 Css NA 0.1057 mg/L 3compartmentss NA 50% Human Human +DTXSID4046076 Css NA 0.7972 mg/L 3compartmentss NA 95% Human Human +DTXSID4046076 Css NA 0.08058 mg/L PBTK NA 50% Human Human +DTXSID4046076 Css NA 0.5384 mg/L PBTK NA 95% Human Human +DTXSID4046076 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046076 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046076 Vd NA 0.8911 L/kg 1compartment NA NA Rat Human DTXSID4046076 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046076 TK.Half.Life NA 3.043 hours 1compartment NA NA Rat Human -DTXSID4046076 Css NA 0.1243 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046076 Css NA 0.8577 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046076 Css NA 0.0986 mg/L PBTK NA 50% Rat Human -DTXSID4046076 Css NA 0.552 mg/L PBTK NA 95% Rat Human -DTXSID4046078 Clint NA 76.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046078 Fup NA 0.3891 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046078 Vd NA 3.975 L/kg 1compartment NA NA Human Human +DTXSID4046076 TK.Half.Life NA 1.275 hours 1compartment NA NA Rat Human +DTXSID4046076 Css NA 0.001015 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046076 Css NA 0.006286 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046076 Css NA 0.0007416 mg/L PBTK NA 50% Rat Human +DTXSID4046076 Css NA 0.004037 mg/L PBTK NA 95% Rat Human +DTXSID4046078 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046078 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046078 Vd NA 3.703 L/kg 1compartment NA NA Human Human DTXSID4046078 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046078 TK.Half.Life NA 2.21 hours 1compartment NA NA Human Human -DTXSID4046078 Css NA 0.009635 mg/L 3compartmentss NA 50% Human Human -DTXSID4046078 Css NA 0.09334 mg/L 3compartmentss NA 95% Human Human -DTXSID4046078 Css NA 0.0117 mg/L PBTK NA 50% Human Human -DTXSID4046078 Css NA 0.0898 mg/L PBTK NA 95% Human Human -DTXSID4046078 Clint NA 76.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046078 Fup NA 0.3891 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046078 Vd NA 3.95 L/kg 1compartment NA NA Rat Human +DTXSID4046078 TK.Half.Life NA 7.498 hours 1compartment NA NA Human Human +DTXSID4046078 Css NA 0.1201 mg/L 3compartmentss NA 50% Human Human +DTXSID4046078 Css NA 0.8629 mg/L 3compartmentss NA 95% Human Human +DTXSID4046078 Css NA 0.1393 mg/L PBTK NA 50% Human Human +DTXSID4046078 Css NA 0.8059 mg/L PBTK NA 95% Human Human +DTXSID4046078 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046078 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046078 Vd NA 3.673 L/kg 1compartment NA NA Rat Human DTXSID4046078 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046078 TK.Half.Life NA 1.039 hours 1compartment NA NA Rat Human -DTXSID4046078 Css NA 0.005074 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046078 Css NA 0.03807 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046078 Css NA 0.006222 mg/L PBTK NA 50% Rat Human -DTXSID4046078 Css NA 0.03624 mg/L PBTK NA 95% Rat Human -DTXSID4046101 Clint NA 19.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046101 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046101 Vd NA 0.53 L/kg 1compartment NA NA Human Human -DTXSID4046101 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4046101 TK.Half.Life NA 15.14 hours 1compartment NA NA Human Human -DTXSID4046101 Css NA 5.368 mg/L 3compartmentss NA 50% Human Human -DTXSID4046101 Css NA 49.01 mg/L 3compartmentss NA 95% Human Human -DTXSID4046101 Css NA 3.179 mg/L PBTK NA 50% Human Human -DTXSID4046101 Css NA 28.54 mg/L PBTK NA 95% Human Human -DTXSID4046101 Clint NA 19.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046101 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046101 Vd NA 0.3994 L/kg 1compartment NA NA Rat Human +DTXSID4046078 TK.Half.Life NA 4.042 hours 1compartment NA NA Rat Human +DTXSID4046078 Css NA 0.0136 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046078 Css NA 0.07587 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046078 Css NA 0.01645 mg/L PBTK NA 50% Rat Human +DTXSID4046078 Css NA 0.06684 mg/L PBTK NA 95% Rat Human +DTXSID4046101 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046101 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046101 Vd NA 0.5971 L/kg 1compartment NA NA Human Human +DTXSID4046101 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046101 TK.Half.Life NA 4.412 hours 1compartment NA NA Human Human +DTXSID4046101 Css NA 1.101 mg/L 3compartmentss NA 50% Human Human +DTXSID4046101 Css NA 7.72 mg/L 3compartmentss NA 95% Human Human +DTXSID4046101 Css NA 0.6844 mg/L PBTK NA 50% Human Human +DTXSID4046101 Css NA 4.522 mg/L PBTK NA 95% Human Human +DTXSID4046101 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046101 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046101 Vd NA 0.4941 L/kg 1compartment NA NA Rat Human DTXSID4046101 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046101 TK.Half.Life NA 7.45 hours 1compartment NA NA Rat Human -DTXSID4046101 Css NA 2.993 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046101 Css NA 24.23 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046101 Css NA 1.645 mg/L PBTK NA 50% Rat Human -DTXSID4046101 Css NA 13.11 mg/L PBTK NA 95% Rat Human -DTXSID4046103 Clint NA 1.179 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046103 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046103 Vd NA 0.374 L/kg 1compartment NA NA Human Human -DTXSID4046103 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4046103 TK.Half.Life NA 21.06 hours 1compartment NA NA Human Human -DTXSID4046103 Css NA 9.833 mg/L 3compartmentss NA 50% Human Human -DTXSID4046103 Css NA 65.46 mg/L 3compartmentss NA 95% Human Human -DTXSID4046103 Css NA 5.89 mg/L PBTK NA 50% Human Human -DTXSID4046103 Css NA 38.16 mg/L PBTK NA 95% Human Human -DTXSID4046103 Clint NA 1.179 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046103 Fup NA 0.0385 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046103 Vd NA 0.3134 L/kg 1compartment NA NA Rat Human +DTXSID4046101 TK.Half.Life NA 2.189 hours 1compartment NA NA Rat Human +DTXSID4046101 Css NA 0.1344 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046101 Css NA 0.6908 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046101 Css NA 0.08155 mg/L PBTK NA 50% Rat Human +DTXSID4046101 Css NA 0.3992 mg/L PBTK NA 95% Rat Human +DTXSID4046103 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046103 Fup 0.0735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046103 Vd NA 0.5656 L/kg 1compartment NA NA Human Human +DTXSID4046103 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046103 TK.Half.Life NA 1.806 hours 1compartment NA NA Human Human +DTXSID4046103 Css NA 0.3867 mg/L 3compartmentss NA 50% Human Human +DTXSID4046103 Css NA 3.186 mg/L 3compartmentss NA 95% Human Human +DTXSID4046103 Css NA 0.2393 mg/L PBTK NA 50% Human Human +DTXSID4046103 Css NA 1.909 mg/L PBTK NA 95% Human Human +DTXSID4046103 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046103 Fup 0.0735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046103 Vd NA 0.4603 L/kg 1compartment NA NA Rat Human DTXSID4046103 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046103 TK.Half.Life NA 9.048 hours 1compartment NA NA Rat Human -DTXSID4046103 Css NA 4.297 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046103 Css NA 22.03 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046103 Css NA 2.41 mg/L PBTK NA 50% Rat Human -DTXSID4046103 Css NA 11.99 mg/L PBTK NA 95% Rat Human -DTXSID4046107 Clint NA 14.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046107 Fup NA 0.2958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046107 Vd NA 0.6753 L/kg 1compartment NA NA Human Human -DTXSID4046107 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046107 TK.Half.Life NA 1.083 hours 1compartment NA NA Human Human -DTXSID4046107 Css NA 0.1101 mg/L 3compartmentss NA 50% Human Human -DTXSID4046107 Css NA 0.7727 mg/L 3compartmentss NA 95% Human Human -DTXSID4046107 Css NA 0.07906 mg/L PBTK NA 50% Human Human -DTXSID4046107 Css NA 0.5041 mg/L PBTK NA 95% Human Human -DTXSID4046107 Clint NA 14.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046107 Fup NA 0.2958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046107 Vd NA 0.6259 L/kg 1compartment NA NA Rat Human +DTXSID4046103 TK.Half.Life NA 0.8763 hours 1compartment NA NA Rat Human +DTXSID4046103 Css NA 0.0512 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046103 Css NA 0.3236 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046103 Css NA 0.03093 mg/L PBTK NA 50% Rat Human +DTXSID4046103 Css NA 0.1888 mg/L PBTK NA 95% Rat Human +DTXSID4046107 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046107 Fup 0.443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046107 Vd NA 0.925 L/kg 1compartment NA NA Human Human +DTXSID4046107 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4046107 TK.Half.Life NA 14.14 hours 1compartment NA NA Human Human +DTXSID4046107 Css NA 1.558 mg/L 3compartmentss NA 50% Human Human +DTXSID4046107 Css NA 7.345 mg/L 3compartmentss NA 95% Human Human +DTXSID4046107 Css NA 1.231 mg/L PBTK NA 50% Human Human +DTXSID4046107 Css NA 4.754 mg/L PBTK NA 95% Human Human +DTXSID4046107 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046107 Fup 0.443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046107 Vd NA 0.845 L/kg 1compartment NA NA Rat Human DTXSID4046107 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046107 TK.Half.Life NA 0.5497 hours 1compartment NA NA Rat Human -DTXSID4046107 Css NA 0.05891 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046107 Css NA 0.3074 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046107 Css NA 0.0405 mg/L PBTK NA 50% Rat Human -DTXSID4046107 Css NA 0.1934 mg/L PBTK NA 95% Rat Human -DTXSID4046109 Clint NA 18.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046109 Fup NA 0.0708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046109 Vd NA 2.251 L/kg 1compartment NA NA Human Human +DTXSID4046107 TK.Half.Life NA 4.252 hours 1compartment NA NA Rat Human +DTXSID4046107 Css NA 0.09956 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046107 Css NA 0.3975 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046107 Css NA 0.07818 mg/L PBTK NA 50% Rat Human +DTXSID4046107 Css NA 0.2506 mg/L PBTK NA 95% Rat Human +DTXSID4046109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046109 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046109 Vd NA 2.656 L/kg 1compartment NA NA Human Human DTXSID4046109 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046109 TK.Half.Life NA 12.17 hours 1compartment NA NA Human Human -DTXSID4046109 Css NA 0.6591 mg/L 3compartmentss NA 50% Human Human -DTXSID4046109 Css NA 4.43 mg/L 3compartmentss NA 95% Human Human -DTXSID4046109 Css NA 0.4456 mg/L PBTK NA 50% Human Human -DTXSID4046109 Css NA 2.848 mg/L PBTK NA 95% Human Human -DTXSID4046109 Clint NA 18.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046109 Fup NA 0.0708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046109 Vd NA 1.696 L/kg 1compartment NA NA Rat Human +DTXSID4046109 TK.Half.Life NA 10.02 hours 1compartment NA NA Human Human +DTXSID4046109 Css NA 0.3808 mg/L 3compartmentss NA 50% Human Human +DTXSID4046109 Css NA 2.483 mg/L 3compartmentss NA 95% Human Human +DTXSID4046109 Css NA 0.2688 mg/L PBTK NA 50% Human Human +DTXSID4046109 Css NA 1.649 mg/L PBTK NA 95% Human Human +DTXSID4046109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046109 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046109 Vd NA 2.012 L/kg 1compartment NA NA Rat Human DTXSID4046109 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046109 TK.Half.Life NA 3.591 hours 1compartment NA NA Rat Human -DTXSID4046109 Css NA 0.3676 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046109 Css NA 1.803 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046109 Css NA 0.2355 mg/L PBTK NA 50% Rat Human -DTXSID4046109 Css NA 1.11 mg/L PBTK NA 95% Rat Human -DTXSID4046151 Clint NA 0.1982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046151 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046151 Vd NA 0.1854 L/kg 1compartment NA NA Human Human -DTXSID4046151 Days.Css NA 39 Days PBTK NA NA Human Human -DTXSID4046151 TK.Half.Life NA 169.4 hours 1compartment NA NA Human Human -DTXSID4046151 Css NA 155.2 mg/L 3compartmentss NA 50% Human Human -DTXSID4046151 Css NA 1003 mg/L 3compartmentss NA 95% Human Human -DTXSID4046151 Css NA 91.1 mg/L PBTK NA 50% Human Human -DTXSID4046151 Css NA 584.8 mg/L PBTK NA 95% Human Human -DTXSID4046151 Clint NA 0.1982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046151 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046151 Vd NA 0.1763 L/kg 1compartment NA NA Rat Human -DTXSID4046151 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID4046151 TK.Half.Life NA 63.07 hours 1compartment NA NA Rat Human -DTXSID4046151 Css NA 52.09 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046151 Css NA 293 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046151 Css NA 28.28 mg/L PBTK NA 50% Rat Human -DTXSID4046151 Css NA 158.4 mg/L PBTK NA 95% Rat Human -DTXSID4046153 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046153 Fup NA 0.305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046153 Vd NA 0.4347 L/kg 1compartment NA NA Human Human -DTXSID4046153 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046153 TK.Half.Life NA 9.228 hours 1compartment NA NA Human Human -DTXSID4046153 Css NA 2.509 mg/L 3compartmentss NA 50% Human Human -DTXSID4046153 Css NA 10.05 mg/L 3compartmentss NA 95% Human Human -DTXSID4046153 Css NA 1.739 mg/L PBTK NA 50% Human Human -DTXSID4046153 Css NA 6.22 mg/L PBTK NA 95% Human Human -DTXSID4046153 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046153 Fup NA 0.305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046153 Vd NA 0.444 L/kg 1compartment NA NA Rat Human +DTXSID4046109 TK.Half.Life NA 2.475 hours 1compartment NA NA Rat Human +DTXSID4046109 Css NA 0.04825 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046109 Css NA 0.2597 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046109 Css NA 0.03384 mg/L PBTK NA 50% Rat Human +DTXSID4046109 Css NA 0.1754 mg/L PBTK NA 95% Rat Human +DTXSID4046151 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046151 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046151 Vd NA 0.2492 L/kg 1compartment NA NA Human Human +DTXSID4046151 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046151 TK.Half.Life NA 5.728 hours 1compartment NA NA Human Human +DTXSID4046151 Css NA 4.082 mg/L 3compartmentss NA 50% Human Human +DTXSID4046151 Css NA 34.1 mg/L 3compartmentss NA 95% Human Human +DTXSID4046151 Css NA 2.441 mg/L PBTK NA 50% Human Human +DTXSID4046151 Css NA 20.17 mg/L PBTK NA 95% Human Human +DTXSID4046151 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046151 Fup 0.0252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046151 Vd NA 0.2289 L/kg 1compartment NA NA Rat Human +DTXSID4046151 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046151 TK.Half.Life NA 3.328 hours 1compartment NA NA Rat Human +DTXSID4046151 Css NA 0.503 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046151 Css NA 3.347 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046151 Css NA 0.2884 mg/L PBTK NA 50% Rat Human +DTXSID4046151 Css NA 1.885 mg/L PBTK NA 95% Rat Human +DTXSID4046153 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046153 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046153 Vd NA 0.3961 L/kg 1compartment NA NA Human Human +DTXSID4046153 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4046153 TK.Half.Life NA 10.34 hours 1compartment NA NA Human Human +DTXSID4046153 Css NA 1.701 mg/L 3compartmentss NA 50% Human Human +DTXSID4046153 Css NA 7.026 mg/L 3compartmentss NA 95% Human Human +DTXSID4046153 Css NA 1.148 mg/L PBTK NA 50% Human Human +DTXSID4046153 Css NA 4.309 mg/L PBTK NA 95% Human Human +DTXSID4046153 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046153 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046153 Vd NA 0.403 L/kg 1compartment NA NA Rat Human DTXSID4046153 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046153 TK.Half.Life NA 3.211 hours 1compartment NA NA Rat Human -DTXSID4046153 Css NA 0.703 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046153 Css NA 2.273 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046153 Css NA 0.4597 mg/L PBTK NA 50% Rat Human -DTXSID4046153 Css NA 1.317 mg/L PBTK NA 95% Rat Human -DTXSID4046155 Clint NA 0.4254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046155 Fup NA 0.0411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046155 Vd NA 0.3354 L/kg 1compartment NA NA Human Human -DTXSID4046155 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID4046155 TK.Half.Life NA 30.83 hours 1compartment NA NA Human Human -DTXSID4046155 Css NA 15.75 mg/L 3compartmentss NA 50% Human Human -DTXSID4046155 Css NA 94.98 mg/L 3compartmentss NA 95% Human Human -DTXSID4046155 Css NA 9.415 mg/L PBTK NA 50% Human Human -DTXSID4046155 Css NA 55.69 mg/L PBTK NA 95% Human Human -DTXSID4046155 Clint NA 0.4254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046155 Fup NA 0.0411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046155 Vd NA 0.2947 L/kg 1compartment NA NA Rat Human -DTXSID4046155 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4046155 TK.Half.Life NA 11.71 hours 1compartment NA NA Rat Human -DTXSID4046155 Css NA 5.833 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046155 Css NA 28.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046155 Css NA 3.259 mg/L PBTK NA 50% Rat Human -DTXSID4046155 Css NA 15.46 mg/L PBTK NA 95% Rat Human -DTXSID4046157 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046157 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046157 Vd NA 0.2187 L/kg 1compartment NA NA Human Human -DTXSID4046157 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID4046157 TK.Half.Life NA 83.34 hours 1compartment NA NA Human Human -DTXSID4046157 Css NA 65.09 mg/L 3compartmentss NA 50% Human Human -DTXSID4046157 Css NA 393 mg/L 3compartmentss NA 95% Human Human -DTXSID4046157 Css NA 38.47 mg/L PBTK NA 50% Human Human -DTXSID4046157 Css NA 228.6 mg/L PBTK NA 95% Human Human -DTXSID4046157 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046157 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046157 Vd NA 0.2082 L/kg 1compartment NA NA Rat Human -DTXSID4046157 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID4046157 TK.Half.Life NA 27 hours 1compartment NA NA Rat Human -DTXSID4046157 Css NA 18.62 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046157 Css NA 99.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046157 Css NA 10.26 mg/L PBTK NA 50% Rat Human -DTXSID4046157 Css NA 53.81 mg/L PBTK NA 95% Rat Human -DTXSID4046159 Clint NA 2.547 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046159 Fup NA 0.8335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046159 Vd NA 0.9098 L/kg 1compartment NA NA Human Human +DTXSID4046153 TK.Half.Life NA 3.582 hours 1compartment NA NA Rat Human +DTXSID4046153 Css NA 0.009202 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046153 Css NA 0.03758 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046153 Css NA 0.005834 mg/L PBTK NA 50% Rat Human +DTXSID4046153 Css NA 0.02208 mg/L PBTK NA 95% Rat Human +DTXSID4046155 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046155 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046155 Vd NA 0.5552 L/kg 1compartment NA NA Human Human +DTXSID4046155 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046155 TK.Half.Life NA 2.981 hours 1compartment NA NA Human Human +DTXSID4046155 Css NA 0.7195 mg/L 3compartmentss NA 50% Human Human +DTXSID4046155 Css NA 4.923 mg/L 3compartmentss NA 95% Human Human +DTXSID4046155 Css NA 0.46 mg/L PBTK NA 50% Human Human +DTXSID4046155 Css NA 2.97 mg/L PBTK NA 95% Human Human +DTXSID4046155 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046155 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046155 Vd NA 0.4827 L/kg 1compartment NA NA Rat Human +DTXSID4046155 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046155 TK.Half.Life NA 1.545 hours 1compartment NA NA Rat Human +DTXSID4046155 Css NA 0.08727 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046155 Css NA 0.4534 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046155 Css NA 0.0544 mg/L PBTK NA 50% Rat Human +DTXSID4046155 Css NA 0.2652 mg/L PBTK NA 95% Rat Human +DTXSID4046157 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046157 Fup 0.0436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046157 Vd NA 0.3003 L/kg 1compartment NA NA Human Human +DTXSID4046157 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046157 TK.Half.Life NA 1.453 hours 1compartment NA NA Human Human +DTXSID4046157 Css NA 0.6981 mg/L 3compartmentss NA 50% Human Human +DTXSID4046157 Css NA 6.235 mg/L 3compartmentss NA 95% Human Human +DTXSID4046157 Css NA 0.427 mg/L PBTK NA 50% Human Human +DTXSID4046157 Css NA 3.696 mg/L PBTK NA 95% Human Human +DTXSID4046157 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046157 Fup 0.0436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046157 Vd NA 0.2814 L/kg 1compartment NA NA Rat Human +DTXSID4046157 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046157 TK.Half.Life NA 0.8619 hours 1compartment NA NA Rat Human +DTXSID4046157 Css NA 0.09179 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046157 Css NA 0.6707 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046157 Css NA 0.0544 mg/L PBTK NA 50% Rat Human +DTXSID4046157 Css NA 0.3866 mg/L PBTK NA 95% Rat Human +DTXSID4046159 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046159 Fup 0.774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046159 Vd NA 0.7913 L/kg 1compartment NA NA Human Human DTXSID4046159 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046159 TK.Half.Life NA 1.706 hours 1compartment NA NA Human Human -DTXSID4046159 Css NA 0.189 mg/L 3compartmentss NA 50% Human Human -DTXSID4046159 Css NA 1.355 mg/L 3compartmentss NA 95% Human Human -DTXSID4046159 Css NA 0.1592 mg/L PBTK NA 50% Human Human -DTXSID4046159 Css NA 0.934 mg/L PBTK NA 95% Human Human -DTXSID4046159 Clint NA 2.547 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046159 Fup NA 0.8335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046159 Vd NA 0.916 L/kg 1compartment NA NA Rat Human +DTXSID4046159 TK.Half.Life NA 6.646 hours 1compartment NA NA Human Human +DTXSID4046159 Css NA 0.9731 mg/L 3compartmentss NA 50% Human Human +DTXSID4046159 Css NA 6.239 mg/L 3compartmentss NA 95% Human Human +DTXSID4046159 Css NA 0.8128 mg/L PBTK NA 50% Human Human +DTXSID4046159 Css NA 3.991 mg/L PBTK NA 95% Human Human +DTXSID4046159 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046159 Fup 0.774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046159 Vd NA 0.8031 L/kg 1compartment NA NA Rat Human DTXSID4046159 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046159 TK.Half.Life NA 0.9004 hours 1compartment NA NA Rat Human -DTXSID4046159 Css NA 0.08138 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046159 Css NA 0.5367 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046159 Css NA 0.06795 mg/L PBTK NA 50% Rat Human -DTXSID4046159 Css NA 0.3282 mg/L PBTK NA 95% Rat Human -DTXSID4046230 Clint NA 23.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4046159 TK.Half.Life NA 2.291 hours 1compartment NA NA Rat Human +DTXSID4046159 Css NA 0.05793 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046159 Css NA 0.3548 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046159 Css NA 0.04843 mg/L PBTK NA 50% Rat Human +DTXSID4046159 Css NA 0.2202 mg/L PBTK NA 95% Rat Human +DTXSID4046230 Clint 8 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID4046230 Fup 0.089 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4046230 Vd NA 1.247 L/kg 1compartment NA NA Human Human DTXSID4046230 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046230 TK.Half.Life NA 2.979 hours 1compartment NA NA Human Human -DTXSID4046230 Css NA 0.2515 mg/L 3compartmentss NA 50% Human Human -DTXSID4046230 Css NA 2.145 mg/L 3compartmentss NA 95% Human Human -DTXSID4046230 Css NA 0.177 mg/L PBTK NA 50% Human Human -DTXSID4046230 Css NA 1.384 mg/L PBTK NA 95% Human Human -DTXSID4046230 Clint NA 23.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4046230 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human +DTXSID4046230 Css NA 0.68 mg/L 3compartmentss NA 50% Human Human +DTXSID4046230 Css NA 5.283 mg/L 3compartmentss NA 95% Human Human +DTXSID4046230 Css NA 0.4821 mg/L PBTK NA 50% Human Human +DTXSID4046230 Css NA 3.375 mg/L PBTK NA 95% Human Human +DTXSID4046230 Clint 8 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID4046230 Fup 0.089 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4046230 Vd NA 1.234 L/kg 1compartment NA NA Rat Human DTXSID4046230 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046230 TK.Half.Life NA 1.772 hours 1compartment NA NA Rat Human -DTXSID4046230 Css NA 0.1404 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046230 Css NA 0.9481 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046230 Css NA 0.09304 mg/L PBTK NA 50% Rat Human -DTXSID4046230 Css NA 0.5778 mg/L PBTK NA 95% Rat Human -DTXSID4046232 Clint NA 76.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046232 Fup NA 0.1744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046232 Vd NA 1.307 L/kg 1compartment NA NA Human Human +DTXSID4046230 TK.Half.Life NA 4.116 hours 1compartment NA NA Rat Human +DTXSID4046230 Css NA 0.08542 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046230 Css NA 0.4985 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046230 Css NA 0.05904 mg/L PBTK NA 50% Rat Human +DTXSID4046230 Css NA 0.3085 mg/L PBTK NA 95% Rat Human +DTXSID4046232 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046232 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046232 Vd NA 1.644 L/kg 1compartment NA NA Human Human DTXSID4046232 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046232 TK.Half.Life NA 1.448 hours 1compartment NA NA Human Human -DTXSID4046232 Css NA 0.04098 mg/L 3compartmentss NA 50% Human Human -DTXSID4046232 Css NA 0.2892 mg/L 3compartmentss NA 95% Human Human -DTXSID4046232 Css NA 0.02871 mg/L PBTK NA 50% Human Human -DTXSID4046232 Css NA 0.1951 mg/L PBTK NA 95% Human Human -DTXSID4046232 Clint NA 76.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046232 Fup NA 0.1744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046232 Vd NA 1.036 L/kg 1compartment NA NA Rat Human +DTXSID4046232 TK.Half.Life NA 5.536 hours 1compartment NA NA Human Human +DTXSID4046232 Css NA 0.313 mg/L 3compartmentss NA 50% Human Human +DTXSID4046232 Css NA 1.86 mg/L 3compartmentss NA 95% Human Human +DTXSID4046232 Css NA 0.2337 mg/L PBTK NA 50% Human Human +DTXSID4046232 Css NA 1.269 mg/L PBTK NA 95% Human Human +DTXSID4046232 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046232 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046232 Vd NA 1.306 L/kg 1compartment NA NA Rat Human DTXSID4046232 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046232 TK.Half.Life NA 0.5484 hours 1compartment NA NA Rat Human -DTXSID4046232 Css NA 0.02271 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046232 Css NA 0.1315 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046232 Css NA 0.01522 mg/L PBTK NA 50% Rat Human -DTXSID4046232 Css NA 0.0833 mg/L PBTK NA 95% Rat Human -DTXSID4046234 Clint NA 14.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046234 Fup NA 0.0523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046234 Vd NA 1.255 L/kg 1compartment NA NA Human Human +DTXSID4046232 TK.Half.Life NA 2.122 hours 1compartment NA NA Rat Human +DTXSID4046232 Css NA 0.03659 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046232 Css NA 0.158 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046232 Css NA 0.0272 mg/L PBTK NA 50% Rat Human +DTXSID4046232 Css NA 0.1053 mg/L PBTK NA 95% Rat Human +DTXSID4046234 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046234 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046234 Vd NA 1.232 L/kg 1compartment NA NA Human Human DTXSID4046234 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046234 TK.Half.Life NA 7.578 hours 1compartment NA NA Human Human -DTXSID4046234 Css NA 0.8955 mg/L 3compartmentss NA 50% Human Human -DTXSID4046234 Css NA 6.39 mg/L 3compartmentss NA 95% Human Human -DTXSID4046234 Css NA 0.5659 mg/L PBTK NA 50% Human Human -DTXSID4046234 Css NA 3.911 mg/L PBTK NA 95% Human Human -DTXSID4046234 Clint NA 14.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046234 Fup NA 0.0523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046234 Vd NA 0.9494 L/kg 1compartment NA NA Rat Human +DTXSID4046234 TK.Half.Life NA 2.894 hours 1compartment NA NA Human Human +DTXSID4046234 Css NA 0.2286 mg/L 3compartmentss NA 50% Human Human +DTXSID4046234 Css NA 1.811 mg/L 3compartmentss NA 95% Human Human +DTXSID4046234 Css NA 0.153 mg/L PBTK NA 50% Human Human +DTXSID4046234 Css NA 1.138 mg/L PBTK NA 95% Human Human +DTXSID4046234 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046234 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046234 Vd NA 0.9634 L/kg 1compartment NA NA Rat Human DTXSID4046234 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046234 TK.Half.Life NA 3.134 hours 1compartment NA NA Rat Human -DTXSID4046234 Css NA 0.4886 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046234 Css NA 2.842 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046234 Css NA 0.291 mg/L PBTK NA 50% Rat Human -DTXSID4046234 Css NA 1.624 mg/L PBTK NA 95% Rat Human -DTXSID4046236 Clint NA 41.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046236 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046236 Vd NA 1.943 L/kg 1compartment NA NA Human Human -DTXSID4046236 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046236 TK.Half.Life NA 5.255 hours 1compartment NA NA Human Human -DTXSID4046236 Css NA 0.279 mg/L 3compartmentss NA 50% Human Human -DTXSID4046236 Css NA 1.948 mg/L 3compartmentss NA 95% Human Human -DTXSID4046236 Css NA 0.1851 mg/L PBTK NA 50% Human Human -DTXSID4046236 Css NA 1.235 mg/L PBTK NA 95% Human Human -DTXSID4046236 Clint NA 41.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046236 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046236 Vd NA 1.462 L/kg 1compartment NA NA Rat Human -DTXSID4046236 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046236 TK.Half.Life NA 1.77 hours 1compartment NA NA Rat Human -DTXSID4046236 Css NA 0.1567 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046236 Css NA 0.8374 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046236 Css NA 0.09834 mg/L PBTK NA 50% Rat Human -DTXSID4046236 Css NA 0.5118 mg/L PBTK NA 95% Rat Human -DTXSID4046280 Clint NA 53.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046280 Fup NA 0.0853 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046280 Vd NA 3.125 L/kg 1compartment NA NA Human Human -DTXSID4046280 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4046280 TK.Half.Life NA 22.45 hours 1compartment NA NA Human Human -DTXSID4046280 Css NA 0.7931 mg/L 3compartmentss NA 50% Human Human -DTXSID4046280 Css NA 5.075 mg/L 3compartmentss NA 95% Human Human -DTXSID4046280 Css NA 0.5554 mg/L PBTK NA 50% Human Human -DTXSID4046280 Css NA 3.415 mg/L PBTK NA 95% Human Human -DTXSID4046280 Clint NA 53.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046280 Fup NA 0.0853 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046280 Vd NA 2.355 L/kg 1compartment NA NA Rat Human -DTXSID4046280 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4046280 TK.Half.Life NA 3.555 hours 1compartment NA NA Rat Human -DTXSID4046280 Css NA 0.4434 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046280 Css NA 2.373 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046280 Css NA 0.2964 mg/L PBTK NA 50% Rat Human -DTXSID4046280 Css NA 1.552 mg/L PBTK NA 95% Rat Human -DTXSID4046282 Clint NA 1.041 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046282 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046282 Vd NA 0.1717 L/kg 1compartment NA NA Human Human -DTXSID4046282 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4046282 TK.Half.Life NA 24.67 hours 1compartment NA NA Human Human -DTXSID4046282 Css NA 25.85 mg/L 3compartmentss NA 50% Human Human -DTXSID4046282 Css NA 170.8 mg/L 3compartmentss NA 95% Human Human -DTXSID4046282 Css NA 15.1 mg/L PBTK NA 50% Human Human -DTXSID4046282 Css NA 98.39 mg/L PBTK NA 95% Human Human -DTXSID4046282 Clint NA 1.041 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046282 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046282 Vd NA 0.1703 L/kg 1compartment NA NA Rat Human -DTXSID4046282 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4046282 TK.Half.Life NA 12.36 hours 1compartment NA NA Rat Human -DTXSID4046282 Css NA 10.72 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046282 Css NA 61.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046282 Css NA 5.834 mg/L PBTK NA 50% Rat Human -DTXSID4046282 Css NA 33.14 mg/L PBTK NA 95% Rat Human -DTXSID4046284 Clint NA 0.06982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046284 Fup NA 0.0785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046284 Vd NA 0.2583 L/kg 1compartment NA NA Human Human -DTXSID4046284 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4046284 TK.Half.Life NA 19.09 hours 1compartment NA NA Human Human -DTXSID4046284 Css NA 11.59 mg/L 3compartmentss NA 50% Human Human -DTXSID4046284 Css NA 54.77 mg/L 3compartmentss NA 95% Human Human -DTXSID4046284 Css NA 7.082 mg/L PBTK NA 50% Human Human -DTXSID4046284 Css NA 31.92 mg/L PBTK NA 95% Human Human -DTXSID4046284 Clint NA 0.06982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046284 Fup NA 0.0785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046284 Vd NA 0.2543 L/kg 1compartment NA NA Rat Human +DTXSID4046234 TK.Half.Life NA 1.199 hours 1compartment NA NA Rat Human +DTXSID4046234 Css NA 0.02944 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046234 Css NA 0.1779 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046234 Css NA 0.01928 mg/L PBTK NA 50% Rat Human +DTXSID4046234 Css NA 0.1093 mg/L PBTK NA 95% Rat Human +DTXSID4046236 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046236 Fup 0.025 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046236 Vd NA 1.812 L/kg 1compartment NA NA Human Human +DTXSID4046236 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4046236 TK.Half.Life NA 46.68 hours 1compartment NA NA Human Human +DTXSID4046236 Css NA 4.086 mg/L 3compartmentss NA 50% Human Human +DTXSID4046236 Css NA 30.45 mg/L 3compartmentss NA 95% Human Human +DTXSID4046236 Css NA 2.624 mg/L PBTK NA 50% Human Human +DTXSID4046236 Css NA 18.53 mg/L PBTK NA 95% Human Human +DTXSID4046236 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046236 Fup 0.025 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046236 Vd NA 1.348 L/kg 1compartment NA NA Rat Human +DTXSID4046236 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4046236 TK.Half.Life NA 15.66 hours 1compartment NA NA Rat Human +DTXSID4046236 Css NA 0.504 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046236 Css NA 2.814 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046236 Css NA 0.3142 mg/L PBTK NA 50% Rat Human +DTXSID4046236 Css NA 1.644 mg/L PBTK NA 95% Rat Human +DTXSID4046238 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046238 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046238 Vd NA 3.632 L/kg 1compartment NA NA Human Human +DTXSID4046238 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046238 TK.Half.Life NA 6.985 hours 1compartment NA NA Human Human +DTXSID4046238 Css NA 0.1274 mg/L 3compartmentss NA 50% Human Human +DTXSID4046238 Css NA 0.8565 mg/L 3compartmentss NA 95% Human Human +DTXSID4046238 Css NA 0.1129 mg/L PBTK NA 50% Human Human +DTXSID4046238 Css NA 0.6773 mg/L PBTK NA 95% Human Human +DTXSID4046238 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046238 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046238 Vd NA 3.098 L/kg 1compartment NA NA Rat Human +DTXSID4046238 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046238 TK.Half.Life NA 2.053 hours 1compartment NA NA Rat Human +DTXSID4046238 Css NA 0.01564 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046238 Css NA 0.08087 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046238 Css NA 0.01422 mg/L PBTK NA 50% Rat Human +DTXSID4046238 Css NA 0.06781 mg/L PBTK NA 95% Rat Human +DTXSID4046280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046280 Fup 0.0669 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046280 Vd NA 3.104 L/kg 1compartment NA NA Human Human +DTXSID4046280 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4046280 TK.Half.Life NA 49.23 hours 1compartment NA NA Human Human +DTXSID4046280 Css NA 1.847 mg/L 3compartmentss NA 50% Human Human +DTXSID4046280 Css NA 12.16 mg/L 3compartmentss NA 95% Human Human +DTXSID4046280 Css NA 1.298 mg/L PBTK NA 50% Human Human +DTXSID4046280 Css NA 8.186 mg/L PBTK NA 95% Human Human +DTXSID4046280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046280 Fup 0.0669 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046280 Vd NA 2.34 L/kg 1compartment NA NA Rat Human +DTXSID4046280 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4046280 TK.Half.Life NA 7.399 hours 1compartment NA NA Rat Human +DTXSID4046280 Css NA 0.2385 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046280 Css NA 1.305 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046280 Css NA 0.1653 mg/L PBTK NA 50% Rat Human +DTXSID4046280 Css NA 0.8976 mg/L PBTK NA 95% Rat Human +DTXSID4046282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046282 Fup 0.0497 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046282 Vd NA 0.2177 L/kg 1compartment NA NA Human Human +DTXSID4046282 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046282 TK.Half.Life NA 0.9642 hours 1compartment NA NA Human Human +DTXSID4046282 Css NA 0.6255 mg/L 3compartmentss NA 50% Human Human +DTXSID4046282 Css NA 5.439 mg/L 3compartmentss NA 95% Human Human +DTXSID4046282 Css NA 0.3735 mg/L PBTK NA 50% Human Human +DTXSID4046282 Css NA 3.187 mg/L PBTK NA 95% Human Human +DTXSID4046282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046282 Fup 0.0497 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046282 Vd NA 0.214 L/kg 1compartment NA NA Rat Human +DTXSID4046282 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046282 TK.Half.Life NA 0.595 hours 1compartment NA NA Rat Human +DTXSID4046282 Css NA 0.08397 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046282 Css NA 0.5362 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046282 Css NA 0.04837 mg/L PBTK NA 50% Rat Human +DTXSID4046282 Css NA 0.3071 mg/L PBTK NA 95% Rat Human +DTXSID4046284 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046284 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046284 Vd NA 0.4229 L/kg 1compartment NA NA Human Human +DTXSID4046284 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4046284 TK.Half.Life NA 9.894 hours 1compartment NA NA Human Human +DTXSID4046284 Css NA 2.738 mg/L 3compartmentss NA 50% Human Human +DTXSID4046284 Css NA 10.57 mg/L 3compartmentss NA 95% Human Human +DTXSID4046284 Css NA 1.857 mg/L PBTK NA 50% Human Human +DTXSID4046284 Css NA 6.559 mg/L PBTK NA 95% Human Human +DTXSID4046284 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046284 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046284 Vd NA 0.4081 L/kg 1compartment NA NA Rat Human DTXSID4046284 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046284 TK.Half.Life NA 6.762 hours 1compartment NA NA Rat Human -DTXSID4046284 Css NA 3.558 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046284 Css NA 14.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046284 Css NA 2.029 mg/L PBTK NA 50% Rat Human -DTXSID4046284 Css NA 7.791 mg/L PBTK NA 95% Rat Human -DTXSID4046286 Clint NA 4.745 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046286 Fup NA 0.0732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046286 Vd NA 0.2227 L/kg 1compartment NA NA Human Human +DTXSID4046284 TK.Half.Life NA 3.241 hours 1compartment NA NA Rat Human +DTXSID4046284 Css NA 0.1768 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046284 Css NA 0.5727 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046284 Css NA 0.1175 mg/L PBTK NA 50% Rat Human +DTXSID4046284 Css NA 0.3411 mg/L PBTK NA 95% Rat Human +DTXSID4046286 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046286 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046286 Vd NA 0.3297 L/kg 1compartment NA NA Human Human DTXSID4046286 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046286 TK.Half.Life NA 2.373 hours 1compartment NA NA Human Human -DTXSID4046286 Css NA 1.781 mg/L 3compartmentss NA 50% Human Human -DTXSID4046286 Css NA 11.39 mg/L 3compartmentss NA 95% Human Human -DTXSID4046286 Css NA 1.068 mg/L PBTK NA 50% Human Human -DTXSID4046286 Css NA 6.665 mg/L PBTK NA 95% Human Human -DTXSID4046286 Clint NA 4.745 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046286 Fup NA 0.0732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046286 Vd NA 0.2219 L/kg 1compartment NA NA Rat Human +DTXSID4046286 TK.Half.Life NA 1.041 hours 1compartment NA NA Human Human +DTXSID4046286 Css NA 0.2728 mg/L 3compartmentss NA 50% Human Human +DTXSID4046286 Css NA 1.698 mg/L 3compartmentss NA 95% Human Human +DTXSID4046286 Css NA 0.1787 mg/L PBTK NA 50% Human Human +DTXSID4046286 Css NA 1.063 mg/L PBTK NA 95% Human Human +DTXSID4046286 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046286 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046286 Vd NA 0.3314 L/kg 1compartment NA NA Rat Human DTXSID4046286 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046286 TK.Half.Life NA 1.439 hours 1compartment NA NA Rat Human -DTXSID4046286 Css NA 0.9163 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046286 Css NA 4.286 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046286 Css NA 0.5136 mg/L PBTK NA 50% Rat Human -DTXSID4046286 Css NA 2.352 mg/L PBTK NA 95% Rat Human -DTXSID4046288 Clint NA 2.308 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046288 Fup NA 0.4946 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046288 Vd NA 2.224 L/kg 1compartment NA NA Human Human -DTXSID4046288 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046288 TK.Half.Life NA 8.037 hours 1compartment NA NA Human Human -DTXSID4046288 Css NA 0.3107 mg/L 3compartmentss NA 50% Human Human -DTXSID4046288 Css NA 2.029 mg/L 3compartmentss NA 95% Human Human -DTXSID4046288 Css NA 0.2874 mg/L PBTK NA 50% Human Human -DTXSID4046288 Css NA 1.476 mg/L PBTK NA 95% Human Human -DTXSID4046288 Clint NA 2.308 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046288 Fup NA 0.4946 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046288 Vd NA 2.018 L/kg 1compartment NA NA Rat Human -DTXSID4046288 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046288 TK.Half.Life NA 3.437 hours 1compartment NA NA Rat Human -DTXSID4046288 Css NA 0.1387 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046288 Css NA 0.7126 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046288 Css NA 0.1266 mg/L PBTK NA 50% Rat Human -DTXSID4046288 Css NA 0.4782 mg/L PBTK NA 95% Rat Human +DTXSID4046286 TK.Half.Life NA 0.6075 hours 1compartment NA NA Rat Human +DTXSID4046286 Css NA 0.01216 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046286 Css NA 0.08507 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046286 Css NA 0.007778 mg/L PBTK NA 50% Rat Human +DTXSID4046286 Css NA 0.05127 mg/L PBTK NA 95% Rat Human +DTXSID4046288 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046288 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046288 Vd NA 2.389 L/kg 1compartment NA NA Human Human +DTXSID4046288 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4046288 TK.Half.Life NA 35.22 hours 1compartment NA NA Human Human +DTXSID4046288 Css NA 1.309 mg/L 3compartmentss NA 50% Human Human +DTXSID4046288 Css NA 8.504 mg/L 3compartmentss NA 95% Human Human +DTXSID4046288 Css NA 1.261 mg/L PBTK NA 50% Human Human +DTXSID4046288 Css NA 5.846 mg/L PBTK NA 95% Human Human +DTXSID4046288 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046288 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046288 Vd NA 2.172 L/kg 1compartment NA NA Rat Human +DTXSID4046288 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4046288 TK.Half.Life NA 9.048 hours 1compartment NA NA Rat Human +DTXSID4046288 Css NA 0.07972 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046288 Css NA 0.504 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046288 Css NA 0.07752 mg/L PBTK NA 50% Rat Human +DTXSID4046288 Css NA 0.3308 mg/L PBTK NA 95% Rat Human DTXSID4046313 Clint 17.91 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4046313 Fup 0.79 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID4046313 Vd NA 2.713 L/kg 1compartment NA NA Human Human DTXSID4046313 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4046313 TK.Half.Life NA 2.191 hours 1compartment NA NA Human Human -DTXSID4046313 Css NA 0.03295 mg/L 3compartmentss NA 50% Human Human -DTXSID4046313 Css NA 0.3248 mg/L 3compartmentss NA 95% Human Human -DTXSID4046313 Css NA 0.03393 mg/L PBTK NA 50% Human Human -DTXSID4046313 Css NA 0.2573 mg/L PBTK NA 95% Human Human +DTXSID4046313 Css NA 0.03094 mg/L 3compartmentss NA 50% Human Human +DTXSID4046313 Css NA 0.3208 mg/L 3compartmentss NA 95% Human Human +DTXSID4046313 Css NA 0.0316 mg/L PBTK NA 50% Human Human +DTXSID4046313 Css NA 0.2529 mg/L PBTK NA 95% Human Human DTXSID4046313 Clint 17.91 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID4046313 Fup 0.79 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID4046313 Vd NA 2.476 L/kg 1compartment NA NA Rat Human DTXSID4046313 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4046313 TK.Half.Life NA 0.9222 hours 1compartment NA NA Rat Human -DTXSID4046313 Css NA 0.01656 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046313 Css NA 0.1464 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046313 Css NA 0.01713 mg/L PBTK NA 50% Rat Human -DTXSID4046313 Css NA 0.1099 mg/L PBTK NA 95% Rat Human -DTXSID4046315 Clint NA 0.5104 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046315 Fup NA 0.5273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046315 Vd NA 3.632 L/kg 1compartment NA NA Human Human -DTXSID4046315 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4046315 TK.Half.Life NA 28.88 hours 1compartment NA NA Human Human -DTXSID4046315 Css NA 0.571 mg/L 3compartmentss NA 50% Human Human -DTXSID4046315 Css NA 3.81 mg/L 3compartmentss NA 95% Human Human -DTXSID4046315 Css NA 0.6726 mg/L PBTK NA 50% Human Human -DTXSID4046315 Css NA 2.913 mg/L PBTK NA 95% Human Human -DTXSID4046315 Clint NA 0.5104 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046315 Fup NA 0.5273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046315 Vd NA 3.541 L/kg 1compartment NA NA Rat Human -DTXSID4046315 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4046315 TK.Half.Life NA 10.83 hours 1compartment NA NA Rat Human -DTXSID4046315 Css NA 0.2002 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046315 Css NA 1.185 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046315 Css NA 0.2355 mg/L PBTK NA 50% Rat Human -DTXSID4046315 Css NA 0.8576 mg/L PBTK NA 95% Rat Human +DTXSID4046313 Css NA 0.003558 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046313 Css NA 0.03243 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046313 Css NA 0.00381 mg/L PBTK NA 50% Rat Human +DTXSID4046313 Css NA 0.02541 mg/L PBTK NA 95% Rat Human +DTXSID4046315 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046315 Fup 0.589 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046315 Vd NA 3.212 L/kg 1compartment NA NA Human Human +DTXSID4046315 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046315 TK.Half.Life NA 4.412 hours 1compartment NA NA Human Human +DTXSID4046315 Css NA 0.0805 mg/L 3compartmentss NA 50% Human Human +DTXSID4046315 Css NA 0.8693 mg/L 3compartmentss NA 95% Human Human +DTXSID4046315 Css NA 0.09246 mg/L PBTK NA 50% Human Human +DTXSID4046315 Css NA 0.6845 mg/L PBTK NA 95% Human Human +DTXSID4046315 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046315 Fup 0.589 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046315 Vd NA 3.204 L/kg 1compartment NA NA Rat Human +DTXSID4046315 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046315 TK.Half.Life NA 2.379 hours 1compartment NA NA Rat Human +DTXSID4046315 Css NA 0.008909 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046315 Css NA 0.08637 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046315 Css NA 0.01068 mg/L PBTK NA 50% Rat Human +DTXSID4046315 Css NA 0.06356 mg/L PBTK NA 95% Rat Human DTXSID4046319 Clint NA 180.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4046319 Fup NA 0.2935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046319 Vd NA 1.776 L/kg 1compartment NA NA Human Human +DTXSID4046319 Vd NA 1.046 L/kg 1compartment NA NA Human Human DTXSID4046319 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046319 TK.Half.Life NA 1.243 hours 1compartment NA NA Human Human -DTXSID4046319 Css NA 0.007498 mg/L 3compartmentss NA 50% Human Human -DTXSID4046319 Css NA 0.06309 mg/L 3compartmentss NA 95% Human Human -DTXSID4046319 Css NA 0.006442 mg/L PBTK NA 50% Human Human -DTXSID4046319 Css NA 0.04695 mg/L PBTK NA 95% Human Human +DTXSID4046319 TK.Half.Life NA 0.8483 hours 1compartment NA NA Human Human +DTXSID4046319 Css NA 0.0051 mg/L 3compartmentss NA 50% Human Human +DTXSID4046319 Css NA 0.05705 mg/L 3compartmentss NA 95% Human Human +DTXSID4046319 Css NA 0.003786 mg/L PBTK NA 50% Human Human +DTXSID4046319 Css NA 0.03977 mg/L PBTK NA 95% Human Human DTXSID4046319 Clint NA 180.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4046319 Fup NA 0.2935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046319 Vd NA 1.747 L/kg 1compartment NA NA Rat Human +DTXSID4046319 Vd NA 0.8889 L/kg 1compartment NA NA Rat Human DTXSID4046319 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046319 TK.Half.Life NA 0.5599 hours 1compartment NA NA Rat Human -DTXSID4046319 Css NA 0.004077 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046319 Css NA 0.02712 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046319 Css NA 0.003403 mg/L PBTK NA 50% Rat Human -DTXSID4046319 Css NA 0.02018 mg/L PBTK NA 95% Rat Human -DTXSID4046361 Clint NA 39.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046361 Fup NA 0.3778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046361 Vd NA 3.074 L/kg 1compartment NA NA Human Human -DTXSID4046361 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046361 TK.Half.Life NA 2.16 hours 1compartment NA NA Human Human -DTXSID4046361 Css NA 0.01953 mg/L 3compartmentss NA 50% Human Human -DTXSID4046361 Css NA 0.1688 mg/L 3compartmentss NA 95% Human Human -DTXSID4046361 Css NA 0.02191 mg/L PBTK NA 50% Human Human -DTXSID4046361 Css NA 0.1511 mg/L PBTK NA 95% Human Human -DTXSID4046361 Clint NA 39.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046361 Fup NA 0.3778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046361 Vd NA 3.118 L/kg 1compartment NA NA Rat Human -DTXSID4046361 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046361 TK.Half.Life NA 1.123 hours 1compartment NA NA Rat Human -DTXSID4046361 Css NA 0.01021 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046361 Css NA 0.07607 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046361 Css NA 0.01136 mg/L PBTK NA 50% Rat Human -DTXSID4046361 Css NA 0.06513 mg/L PBTK NA 95% Rat Human +DTXSID4046319 TK.Half.Life NA 0.3257 hours 1compartment NA NA Rat Human +DTXSID4046319 Css NA 0.0002343 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046319 Css NA 0.003265 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046319 Css NA 0.0001748 mg/L PBTK NA 50% Rat Human +DTXSID4046319 Css NA 0.002142 mg/L PBTK NA 95% Rat Human +DTXSID4046361 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046361 Fup 0.259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046361 Vd NA 2.213 L/kg 1compartment NA NA Human Human +DTXSID4046361 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID4046361 TK.Half.Life NA 61.34 hours 1compartment NA NA Human Human +DTXSID4046361 Css NA 2.152 mg/L 3compartmentss NA 50% Human Human +DTXSID4046361 Css NA 9.299 mg/L 3compartmentss NA 95% Human Human +DTXSID4046361 Css NA 1.928 mg/L PBTK NA 50% Human Human +DTXSID4046361 Css NA 6.578 mg/L PBTK NA 95% Human Human +DTXSID4046361 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046361 Fup 0.259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046361 Vd NA 2.122 L/kg 1compartment NA NA Rat Human +DTXSID4046361 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4046361 TK.Half.Life NA 18.54 hours 1compartment NA NA Rat Human +DTXSID4046361 Css NA 0.05068 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046361 Css NA 0.3006 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046361 Css NA 0.04625 mg/L PBTK NA 50% Rat Human +DTXSID4046361 Css NA 0.2226 mg/L PBTK NA 95% Rat Human DTXSID4046363 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4046363 Fup NA 0.0516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046363 Vd NA 0.2145 L/kg 1compartment NA NA Human Human +DTXSID4046363 Vd NA 0.2149 L/kg 1compartment NA NA Human Human DTXSID4046363 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4046363 TK.Half.Life NA 26.91 hours 1compartment NA NA Human Human -DTXSID4046363 Css NA 21.31 mg/L 3compartmentss NA 50% Human Human -DTXSID4046363 Css NA 99.6 mg/L 3compartmentss NA 95% Human Human -DTXSID4046363 Css NA 12.61 mg/L PBTK NA 50% Human Human -DTXSID4046363 Css NA 57.59 mg/L PBTK NA 95% Human Human +DTXSID4046363 TK.Half.Life NA 26.96 hours 1compartment NA NA Human Human +DTXSID4046363 Css NA 18.08 mg/L 3compartmentss NA 50% Human Human +DTXSID4046363 Css NA 85.93 mg/L 3compartmentss NA 95% Human Human +DTXSID4046363 Css NA 10.68 mg/L PBTK NA 50% Human Human +DTXSID4046363 Css NA 49.51 mg/L PBTK NA 95% Human Human DTXSID4046363 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4046363 Fup NA 0.0516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046363 Vd NA 0.21 L/kg 1compartment NA NA Rat Human +DTXSID4046363 Vd NA 0.2103 L/kg 1compartment NA NA Rat Human DTXSID4046363 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046363 TK.Half.Life NA 8.974 hours 1compartment NA NA Rat Human -DTXSID4046363 Css NA 6.039 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046363 Css NA 25.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046363 Css NA 3.344 mg/L PBTK NA 50% Rat Human -DTXSID4046363 Css NA 13.6 mg/L PBTK NA 95% Rat Human -DTXSID4046440 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046440 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046440 Vd NA 0.7754 L/kg 1compartment NA NA Human Human +DTXSID4046363 TK.Half.Life NA 8.987 hours 1compartment NA NA Rat Human +DTXSID4046363 Css NA 0.3322 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046363 Css NA 2.319 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046363 Css NA 0.1869 mg/L PBTK NA 50% Rat Human +DTXSID4046363 Css NA 1.299 mg/L PBTK NA 95% Rat Human +DTXSID4046440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046440 Fup 0.759 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046440 Vd NA 0.4163 L/kg 1compartment NA NA Human Human DTXSID4046440 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046440 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human -DTXSID4046440 Css NA 0.8314 mg/L 3compartmentss NA 50% Human Human -DTXSID4046440 Css NA 5.571 mg/L 3compartmentss NA 95% Human Human -DTXSID4046440 Css NA 0.6988 mg/L PBTK NA 50% Human Human -DTXSID4046440 Css NA 3.648 mg/L PBTK NA 95% Human Human -DTXSID4046440 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046440 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046440 Vd NA 0.8131 L/kg 1compartment NA NA Rat Human +DTXSID4046440 TK.Half.Life NA 3.549 hours 1compartment NA NA Human Human +DTXSID4046440 Css NA 1.122 mg/L 3compartmentss NA 50% Human Human +DTXSID4046440 Css NA 6.484 mg/L 3compartmentss NA 95% Human Human +DTXSID4046440 Css NA 0.8136 mg/L PBTK NA 50% Human Human +DTXSID4046440 Css NA 4.048 mg/L PBTK NA 95% Human Human +DTXSID4046440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046440 Fup 0.759 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046440 Vd NA 0.4405 L/kg 1compartment NA NA Rat Human DTXSID4046440 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046440 TK.Half.Life NA 1.793 hours 1compartment NA NA Rat Human -DTXSID4046440 Css NA 0.2087 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046440 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046440 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID4046440 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID4046442 Clint NA 26.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046442 Fup NA 0.0663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046442 Vd NA 1.819 L/kg 1compartment NA NA Human Human +DTXSID4046440 TK.Half.Life NA 1.28 hours 1compartment NA NA Rat Human +DTXSID4046440 Css NA 0.06742 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046440 Css NA 0.3852 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046440 Css NA 0.04846 mg/L PBTK NA 50% Rat Human +DTXSID4046440 Css NA 0.2285 mg/L PBTK NA 95% Rat Human +DTXSID4046442 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046442 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046442 Vd NA 2.662 L/kg 1compartment NA NA Human Human DTXSID4046442 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046442 TK.Half.Life NA 4.524 hours 1compartment NA NA Human Human -DTXSID4046442 Css NA 0.2606 mg/L 3compartmentss NA 50% Human Human -DTXSID4046442 Css NA 2.206 mg/L 3compartmentss NA 95% Human Human -DTXSID4046442 Css NA 0.1901 mg/L PBTK NA 50% Human Human -DTXSID4046442 Css NA 1.451 mg/L PBTK NA 95% Human Human -DTXSID4046442 Clint NA 26.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046442 Fup NA 0.0663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046442 Vd NA 1.688 L/kg 1compartment NA NA Rat Human +DTXSID4046442 TK.Half.Life NA 4.919 hours 1compartment NA NA Human Human +DTXSID4046442 Css NA 0.1441 mg/L 3compartmentss NA 50% Human Human +DTXSID4046442 Css NA 1.308 mg/L 3compartmentss NA 95% Human Human +DTXSID4046442 Css NA 0.122 mg/L PBTK NA 50% Human Human +DTXSID4046442 Css NA 0.9645 mg/L PBTK NA 95% Human Human +DTXSID4046442 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046442 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046442 Vd NA 2.496 L/kg 1compartment NA NA Rat Human DTXSID4046442 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046442 TK.Half.Life NA 2.404 hours 1compartment NA NA Rat Human -DTXSID4046442 Css NA 0.1484 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046442 Css NA 0.9394 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046442 Css NA 0.1023 mg/L PBTK NA 50% Rat Human -DTXSID4046442 Css NA 0.5897 mg/L PBTK NA 95% Rat Human -DTXSID4046444 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4046442 TK.Half.Life NA 2.453 hours 1compartment NA NA Rat Human +DTXSID4046442 Css NA 0.0183 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046442 Css NA 0.1285 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046442 Css NA 0.01547 mg/L PBTK NA 50% Rat Human +DTXSID4046442 Css NA 0.09107 mg/L PBTK NA 95% Rat Human +DTXSID4046444 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4046444 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4046444 Vd NA 1.242 L/kg 1compartment NA NA Human Human -DTXSID4046444 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4046444 TK.Half.Life NA 17.97 hours 1compartment NA NA Human Human -DTXSID4046444 Css NA 1.484 mg/L 3compartmentss NA 50% Human Human -DTXSID4046444 Css NA 7.333 mg/L 3compartmentss NA 95% Human Human -DTXSID4046444 Css NA 1.235 mg/L PBTK NA 50% Human Human -DTXSID4046444 Css NA 4.844 mg/L PBTK NA 95% Human Human -DTXSID4046444 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4046444 Vd NA 1.046 L/kg 1compartment NA NA Human Human +DTXSID4046444 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4046444 TK.Half.Life NA 14.35 hours 1compartment NA NA Human Human +DTXSID4046444 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human +DTXSID4046444 Css NA 7.083 mg/L 3compartmentss NA 95% Human Human +DTXSID4046444 Css NA 1.131 mg/L PBTK NA 50% Human Human +DTXSID4046444 Css NA 4.604 mg/L PBTK NA 95% Human Human +DTXSID4046444 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4046444 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4046444 Vd NA 1.085 L/kg 1compartment NA NA Rat Human +DTXSID4046444 Vd NA 0.9526 L/kg 1compartment NA NA Rat Human DTXSID4046444 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046444 TK.Half.Life NA 4.919 hours 1compartment NA NA Rat Human -DTXSID4046444 Css NA 0.395 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046444 Css NA 1.773 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046444 Css NA 0.3171 mg/L PBTK NA 50% Rat Human -DTXSID4046444 Css NA 1.093 mg/L PBTK NA 95% Rat Human -DTXSID4046446 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046446 Fup NA 0.8237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046446 Vd NA 1.318 L/kg 1compartment NA NA Human Human -DTXSID4046446 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4046446 TK.Half.Life NA 10.36 hours 1compartment NA NA Human Human -DTXSID4046446 Css NA 0.896 mg/L 3compartmentss NA 50% Human Human -DTXSID4046446 Css NA 5.641 mg/L 3compartmentss NA 95% Human Human -DTXSID4046446 Css NA 0.8071 mg/L PBTK NA 50% Human Human -DTXSID4046446 Css NA 3.765 mg/L PBTK NA 95% Human Human -DTXSID4046446 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046446 Fup NA 0.8237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046446 Vd NA 1.342 L/kg 1compartment NA NA Rat Human +DTXSID4046444 TK.Half.Life NA 4.26 hours 1compartment NA NA Rat Human +DTXSID4046444 Css NA 0.08585 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046444 Css NA 0.415 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046444 Css NA 0.0702 mg/L PBTK NA 50% Rat Human +DTXSID4046444 Css NA 0.2613 mg/L PBTK NA 95% Rat Human +DTXSID4046446 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046446 Fup 0.745 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046446 Vd NA 0.667 L/kg 1compartment NA NA Human Human +DTXSID4046446 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046446 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human +DTXSID4046446 Css NA 0.581 mg/L 3compartmentss NA 50% Human Human +DTXSID4046446 Css NA 3.639 mg/L 3compartmentss NA 95% Human Human +DTXSID4046446 Css NA 0.4664 mg/L PBTK NA 50% Human Human +DTXSID4046446 Css NA 2.331 mg/L PBTK NA 95% Human Human +DTXSID4046446 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046446 Fup 0.745 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046446 Vd NA 0.695 L/kg 1compartment NA NA Rat Human DTXSID4046446 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046446 TK.Half.Life NA 3.593 hours 1compartment NA NA Rat Human -DTXSID4046446 Css NA 0.2261 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046446 Css NA 1.459 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046446 Css NA 0.1996 mg/L PBTK NA 50% Rat Human -DTXSID4046446 Css NA 0.8992 mg/L PBTK NA 95% Rat Human -DTXSID4046448 Clint NA 5.495 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046448 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046448 Vd NA 2.362 L/kg 1compartment NA NA Human Human -DTXSID4046448 Days.Css NA 24 Days PBTK NA NA Human Human -DTXSID4046448 TK.Half.Life NA 131.4 hours 1compartment NA NA Human Human -DTXSID4046448 Css NA 8.627 mg/L 3compartmentss NA 50% Human Human -DTXSID4046448 Css NA 57.79 mg/L 3compartmentss NA 95% Human Human -DTXSID4046448 Css NA 5.662 mg/L PBTK NA 50% Human Human -DTXSID4046448 Css NA 35.9 mg/L PBTK NA 95% Human Human -DTXSID4046448 Clint NA 5.495 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046448 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046448 Vd NA 1.758 L/kg 1compartment NA NA Rat Human -DTXSID4046448 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID4046448 TK.Half.Life NA 33.85 hours 1compartment NA NA Rat Human -DTXSID4046448 Css NA 4.713 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046448 Css NA 23.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046448 Css NA 2.912 mg/L PBTK NA 50% Rat Human -DTXSID4046448 Css NA 14.02 mg/L PBTK NA 95% Rat Human -DTXSID4046490 Clint NA 28.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046490 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046490 Vd NA 0.7325 L/kg 1compartment NA NA Human Human +DTXSID4046446 TK.Half.Life NA 2.057 hours 1compartment NA NA Rat Human +DTXSID4046446 Css NA 0.00296 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046446 Css NA 0.02104 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046446 Css NA 0.002305 mg/L PBTK NA 50% Rat Human +DTXSID4046446 Css NA 0.01296 mg/L PBTK NA 95% Rat Human +DTXSID4046448 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046448 Fup 0.0173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046448 Vd NA 2.521 L/kg 1compartment NA NA Human Human +DTXSID4046448 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4046448 TK.Half.Life NA 34.3 hours 1compartment NA NA Human Human +DTXSID4046448 Css NA 1.646 mg/L 3compartmentss NA 50% Human Human +DTXSID4046448 Css NA 12.81 mg/L 3compartmentss NA 95% Human Human +DTXSID4046448 Css NA 1.089 mg/L PBTK NA 50% Human Human +DTXSID4046448 Css NA 8.125 mg/L PBTK NA 95% Human Human +DTXSID4046448 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046448 Fup 0.0173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046448 Vd NA 1.88 L/kg 1compartment NA NA Rat Human +DTXSID4046448 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4046448 TK.Half.Life NA 8.337 hours 1compartment NA NA Rat Human +DTXSID4046448 Css NA 0.08412 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046448 Css NA 0.6852 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046448 Css NA 0.05406 mg/L PBTK NA 50% Rat Human +DTXSID4046448 Css NA 0.4189 mg/L PBTK NA 95% Rat Human +DTXSID4046490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046490 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046490 Vd NA 0.8593 L/kg 1compartment NA NA Human Human DTXSID4046490 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046490 TK.Half.Life NA 0.8493 hours 1compartment NA NA Human Human -DTXSID4046490 Css NA 0.05356 mg/L 3compartmentss NA 50% Human Human -DTXSID4046490 Css NA 0.387 mg/L 3compartmentss NA 95% Human Human -DTXSID4046490 Css NA 0.03876 mg/L PBTK NA 50% Human Human -DTXSID4046490 Css NA 0.2604 mg/L PBTK NA 95% Human Human -DTXSID4046490 Clint NA 28.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046490 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046490 Vd NA 0.6696 L/kg 1compartment NA NA Rat Human +DTXSID4046490 TK.Half.Life NA 0.9447 hours 1compartment NA NA Human Human +DTXSID4046490 Css NA 0.04774 mg/L 3compartmentss NA 50% Human Human +DTXSID4046490 Css NA 0.3652 mg/L 3compartmentss NA 95% Human Human +DTXSID4046490 Css NA 0.03653 mg/L PBTK NA 50% Human Human +DTXSID4046490 Css NA 0.2554 mg/L PBTK NA 95% Human Human +DTXSID4046490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046490 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046490 Vd NA 0.7881 L/kg 1compartment NA NA Rat Human DTXSID4046490 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046490 TK.Half.Life NA 0.3984 hours 1compartment NA NA Rat Human -DTXSID4046490 Css NA 0.02891 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046490 Css NA 0.169 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046490 Css NA 0.02007 mg/L PBTK NA 50% Rat Human -DTXSID4046490 Css NA 0.1082 mg/L PBTK NA 95% Rat Human -DTXSID4046492 Clint NA 43.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046492 Fup NA 0.3858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046492 Vd NA 1.323 L/kg 1compartment NA NA Human Human +DTXSID4046490 TK.Half.Life NA 0.4426 hours 1compartment NA NA Rat Human +DTXSID4046490 Css NA 0.005781 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046490 Css NA 0.03672 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046490 Css NA 0.004478 mg/L PBTK NA 50% Rat Human +DTXSID4046490 Css NA 0.02465 mg/L PBTK NA 95% Rat Human +DTXSID4046492 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046492 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046492 Vd NA 1.253 L/kg 1compartment NA NA Human Human DTXSID4046492 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046492 TK.Half.Life NA 1.204 hours 1compartment NA NA Human Human -DTXSID4046492 Css NA 0.02784 mg/L 3compartmentss NA 50% Human Human -DTXSID4046492 Css NA 0.2262 mg/L 3compartmentss NA 95% Human Human -DTXSID4046492 Css NA 0.022 mg/L PBTK NA 50% Human Human -DTXSID4046492 Css NA 0.1621 mg/L PBTK NA 95% Human Human -DTXSID4046492 Clint NA 43.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046492 Fup NA 0.3858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046492 Vd NA 1.144 L/kg 1compartment NA NA Rat Human +DTXSID4046492 TK.Half.Life NA 4.279 hours 1compartment NA NA Human Human +DTXSID4046492 Css NA 0.3258 mg/L 3compartmentss NA 50% Human Human +DTXSID4046492 Css NA 1.913 mg/L 3compartmentss NA 95% Human Human +DTXSID4046492 Css NA 0.2354 mg/L PBTK NA 50% Human Human +DTXSID4046492 Css NA 1.296 mg/L PBTK NA 95% Human Human +DTXSID4046492 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046492 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046492 Vd NA 1.037 L/kg 1compartment NA NA Rat Human DTXSID4046492 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046492 TK.Half.Life NA 0.4969 hours 1compartment NA NA Rat Human -DTXSID4046492 Css NA 0.01518 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046492 Css NA 0.09101 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046492 Css NA 0.01162 mg/L PBTK NA 50% Rat Human -DTXSID4046492 Css NA 0.06372 mg/L PBTK NA 95% Rat Human +DTXSID4046492 TK.Half.Life NA 1.896 hours 1compartment NA NA Rat Human +DTXSID4046492 Css NA 0.03843 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046492 Css NA 0.1629 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046492 Css NA 0.02777 mg/L PBTK NA 50% Rat Human +DTXSID4046492 Css NA 0.1066 mg/L PBTK NA 95% Rat Human DTXSID4046494 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4046494 Fup NA 0.2742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046494 Vd NA 2.651 L/kg 1compartment NA NA Human Human -DTXSID4046494 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID4046494 TK.Half.Life NA 167.7 hours 1compartment NA NA Human Human -DTXSID4046494 Css NA 6.7 mg/L 3compartmentss NA 50% Human Human -DTXSID4046494 Css NA 20.69 mg/L 3compartmentss NA 95% Human Human -DTXSID4046494 Css NA 5.178 mg/L PBTK NA 50% Human Human -DTXSID4046494 Css NA 14.28 mg/L PBTK NA 95% Human Human +DTXSID4046494 Vd NA 2.322 L/kg 1compartment NA NA Human Human +DTXSID4046494 Days.Css NA 23 Days PBTK NA NA Human Human +DTXSID4046494 TK.Half.Life NA 123.5 hours 1compartment NA NA Human Human +DTXSID4046494 Css NA 4.878 mg/L 3compartmentss NA 50% Human Human +DTXSID4046494 Css NA 15.84 mg/L 3compartmentss NA 95% Human Human +DTXSID4046494 Css NA 3.702 mg/L PBTK NA 50% Human Human +DTXSID4046494 Css NA 10.59 mg/L PBTK NA 95% Human Human DTXSID4046494 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4046494 Fup NA 0.2742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046494 Vd NA 2.094 L/kg 1compartment NA NA Rat Human -DTXSID4046494 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID4046494 TK.Half.Life NA 23.58 hours 1compartment NA NA Rat Human -DTXSID4046494 Css NA 1.808 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046494 Css NA 4.632 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046494 Css NA 1.348 mg/L PBTK NA 50% Rat Human -DTXSID4046494 Css NA 2.939 mg/L PBTK NA 95% Rat Human -DTXSID4046498 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046498 Fup NA 0.1488 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046498 Vd NA 0.4237 L/kg 1compartment NA NA Human Human -DTXSID4046498 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4046498 TK.Half.Life NA 18.62 hours 1compartment NA NA Human Human -DTXSID4046498 Css NA 6.236 mg/L 3compartmentss NA 50% Human Human -DTXSID4046498 Css NA 28.18 mg/L 3compartmentss NA 95% Human Human -DTXSID4046498 Css NA 4.026 mg/L PBTK NA 50% Human Human -DTXSID4046498 Css NA 17.02 mg/L PBTK NA 95% Human Human -DTXSID4046498 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046498 Fup NA 0.1488 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046498 Vd NA 0.3877 L/kg 1compartment NA NA Rat Human +DTXSID4046494 Vd NA 1.791 L/kg 1compartment NA NA Rat Human +DTXSID4046494 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4046494 TK.Half.Life NA 18.7 hours 1compartment NA NA Rat Human +DTXSID4046494 Css NA 0.08656 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046494 Css NA 0.4443 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046494 Css NA 0.06297 mg/L PBTK NA 50% Rat Human +DTXSID4046494 Css NA 0.3023 mg/L PBTK NA 95% Rat Human +DTXSID4046498 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046498 Fup 0.0624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046498 Vd NA 0.3543 L/kg 1compartment NA NA Human Human +DTXSID4046498 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046498 TK.Half.Life NA 3.455 hours 1compartment NA NA Human Human +DTXSID4046498 Css NA 1.601 mg/L 3compartmentss NA 50% Human Human +DTXSID4046498 Css NA 10.74 mg/L 3compartmentss NA 95% Human Human +DTXSID4046498 Css NA 0.9748 mg/L PBTK NA 50% Human Human +DTXSID4046498 Css NA 6.265 mg/L PBTK NA 95% Human Human +DTXSID4046498 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046498 Fup 0.0624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046498 Vd NA 0.3128 L/kg 1compartment NA NA Rat Human DTXSID4046498 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046498 TK.Half.Life NA 5.762 hours 1compartment NA NA Rat Human -DTXSID4046498 Css NA 1.756 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046498 Css NA 6.755 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046498 Css NA 1.064 mg/L PBTK NA 50% Rat Human -DTXSID4046498 Css NA 3.773 mg/L PBTK NA 95% Rat Human -DTXSID4046521 Clint NA 0.01881 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046521 Fup NA 0.1465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046521 Vd NA 0.4883 L/kg 1compartment NA NA Human Human -DTXSID4046521 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4046521 TK.Half.Life NA 20.92 hours 1compartment NA NA Human Human -DTXSID4046521 Css NA 5.724 mg/L 3compartmentss NA 50% Human Human -DTXSID4046521 Css NA 28.21 mg/L 3compartmentss NA 95% Human Human -DTXSID4046521 Css NA 3.882 mg/L PBTK NA 50% Human Human -DTXSID4046521 Css NA 17.1 mg/L PBTK NA 95% Human Human -DTXSID4046521 Clint NA 0.01881 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046521 Fup NA 0.1465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046521 Vd NA 0.4835 L/kg 1compartment NA NA Rat Human +DTXSID4046498 TK.Half.Life NA 1.882 hours 1compartment NA NA Rat Human +DTXSID4046498 Css NA 0.1935 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046498 Css NA 0.9872 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046498 Css NA 0.1144 mg/L PBTK NA 50% Rat Human +DTXSID4046498 Css NA 0.5639 mg/L PBTK NA 95% Rat Human +DTXSID4046521 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046521 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046521 Vd NA 1.342 L/kg 1compartment NA NA Human Human +DTXSID4046521 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046521 TK.Half.Life NA 6.802 hours 1compartment NA NA Human Human +DTXSID4046521 Css NA 0.6066 mg/L 3compartmentss NA 50% Human Human +DTXSID4046521 Css NA 3.986 mg/L 3compartmentss NA 95% Human Human +DTXSID4046521 Css NA 0.415 mg/L PBTK NA 50% Human Human +DTXSID4046521 Css NA 2.552 mg/L PBTK NA 95% Human Human +DTXSID4046521 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046521 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046521 Vd NA 1.052 L/kg 1compartment NA NA Rat Human DTXSID4046521 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046521 TK.Half.Life NA 7.169 hours 1compartment NA NA Rat Human -DTXSID4046521 Css NA 1.654 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046521 Css NA 6.856 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046521 Css NA 1.056 mg/L PBTK NA 50% Rat Human -DTXSID4046521 Css NA 3.886 mg/L PBTK NA 95% Rat Human -DTXSID4046523 Clint NA 0.09632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046523 Fup NA 0.2341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046523 Vd NA 0.363 L/kg 1compartment NA NA Human Human +DTXSID4046521 TK.Half.Life NA 2.778 hours 1compartment NA NA Rat Human +DTXSID4046521 Css NA 0.0737 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046521 Css NA 0.3728 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046521 Css NA 0.0494 mg/L PBTK NA 50% Rat Human +DTXSID4046521 Css NA 0.2277 mg/L PBTK NA 95% Rat Human +DTXSID4046523 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046523 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046523 Vd NA 0.4774 L/kg 1compartment NA NA Human Human DTXSID4046523 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046523 TK.Half.Life NA 8.622 hours 1compartment NA NA Human Human -DTXSID4046523 Css NA 2.832 mg/L 3compartmentss NA 50% Human Human -DTXSID4046523 Css NA 10.94 mg/L 3compartmentss NA 95% Human Human -DTXSID4046523 Css NA 1.896 mg/L PBTK NA 50% Human Human -DTXSID4046523 Css NA 6.667 mg/L PBTK NA 95% Human Human -DTXSID4046523 Clint NA 0.09632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046523 Fup NA 0.2341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046523 Vd NA 0.3676 L/kg 1compartment NA NA Rat Human +DTXSID4046523 TK.Half.Life NA 7.607 hours 1compartment NA NA Human Human +DTXSID4046523 Css NA 1.753 mg/L 3compartmentss NA 50% Human Human +DTXSID4046523 Css NA 7.571 mg/L 3compartmentss NA 95% Human Human +DTXSID4046523 Css NA 1.288 mg/L PBTK NA 50% Human Human +DTXSID4046523 Css NA 4.743 mg/L PBTK NA 95% Human Human +DTXSID4046523 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046523 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046523 Vd NA 0.4858 L/kg 1compartment NA NA Rat Human DTXSID4046523 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046523 TK.Half.Life NA 3.208 hours 1compartment NA NA Rat Human -DTXSID4046523 Css NA 0.8658 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046523 Css NA 2.726 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046523 Css NA 0.5466 mg/L PBTK NA 50% Rat Human -DTXSID4046523 Css NA 1.561 mg/L PBTK NA 95% Rat Human -DTXSID4046525 Clint NA 13.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046525 Fup NA 0.6813 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046525 Vd NA 1.127 L/kg 1compartment NA NA Human Human +DTXSID4046523 TK.Half.Life NA 2.639 hours 1compartment NA NA Rat Human +DTXSID4046523 Css NA 0.112 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046523 Css NA 0.4283 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046523 Css NA 0.08082 mg/L PBTK NA 50% Rat Human +DTXSID4046523 Css NA 0.261 mg/L PBTK NA 95% Rat Human +DTXSID4046525 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046525 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046525 Vd NA 0.8714 L/kg 1compartment NA NA Human Human DTXSID4046525 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046525 TK.Half.Life NA 1.101 hours 1compartment NA NA Human Human -DTXSID4046525 Css NA 0.05073 mg/L 3compartmentss NA 50% Human Human -DTXSID4046525 Css NA 0.5022 mg/L 3compartmentss NA 95% Human Human -DTXSID4046525 Css NA 0.04328 mg/L PBTK NA 50% Human Human -DTXSID4046525 Css NA 0.3495 mg/L PBTK NA 95% Human Human -DTXSID4046525 Clint NA 13.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046525 Fup NA 0.6813 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046525 Vd NA 1.045 L/kg 1compartment NA NA Rat Human +DTXSID4046525 TK.Half.Life NA 0.8832 hours 1compartment NA NA Human Human +DTXSID4046525 Css NA 0.03979 mg/L 3compartmentss NA 50% Human Human +DTXSID4046525 Css NA 0.3746 mg/L 3compartmentss NA 95% Human Human +DTXSID4046525 Css NA 0.03157 mg/L PBTK NA 50% Human Human +DTXSID4046525 Css NA 0.2541 mg/L PBTK NA 95% Human Human +DTXSID4046525 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046525 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046525 Vd NA 0.8128 L/kg 1compartment NA NA Rat Human DTXSID4046525 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046525 TK.Half.Life NA 0.5165 hours 1compartment NA NA Rat Human -DTXSID4046525 Css NA 0.02542 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046525 Css NA 0.217 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046525 Css NA 0.02155 mg/L PBTK NA 50% Rat Human -DTXSID4046525 Css NA 0.1382 mg/L PBTK NA 95% Rat Human -DTXSID4046527 Clint NA 0.1118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046527 Fup NA 0.8425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046527 Vd NA 0.5902 L/kg 1compartment NA NA Human Human +DTXSID4046525 TK.Half.Life NA 0.4158 hours 1compartment NA NA Rat Human +DTXSID4046525 Css NA 0.004962 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046525 Css NA 0.03486 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046525 Css NA 0.003942 mg/L PBTK NA 50% Rat Human +DTXSID4046525 Css NA 0.02356 mg/L PBTK NA 95% Rat Human +DTXSID4046527 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046527 Fup 0.766 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046527 Vd NA 0.4398 L/kg 1compartment NA NA Human Human DTXSID4046527 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046527 TK.Half.Life NA 3.842 hours 1compartment NA NA Human Human -DTXSID4046527 Css NA 0.8464 mg/L 3compartmentss NA 50% Human Human -DTXSID4046527 Css NA 4.759 mg/L 3compartmentss NA 95% Human Human -DTXSID4046527 Css NA 0.6576 mg/L PBTK NA 50% Human Human -DTXSID4046527 Css NA 3.015 mg/L PBTK NA 95% Human Human -DTXSID4046527 Clint NA 0.1118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046527 Fup NA 0.8425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046527 Vd NA 0.6001 L/kg 1compartment NA NA Rat Human +DTXSID4046527 TK.Half.Life NA 3.715 hours 1compartment NA NA Human Human +DTXSID4046527 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human +DTXSID4046527 Css NA 6.689 mg/L 3compartmentss NA 95% Human Human +DTXSID4046527 Css NA 0.8117 mg/L PBTK NA 50% Human Human +DTXSID4046527 Css NA 4.137 mg/L PBTK NA 95% Human Human +DTXSID4046527 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046527 Fup 0.766 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046527 Vd NA 0.4628 L/kg 1compartment NA NA Rat Human DTXSID4046527 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046527 TK.Half.Life NA 1.443 hours 1compartment NA NA Rat Human -DTXSID4046527 Css NA 0.2414 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046527 Css NA 1.313 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046527 Css NA 0.1802 mg/L PBTK NA 50% Rat Human -DTXSID4046527 Css NA 0.7734 mg/L PBTK NA 95% Rat Human -DTXSID4046529 Clint NA 19.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046529 Fup NA 0.328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046529 Vd NA 3.502 L/kg 1compartment NA NA Human Human +DTXSID4046527 TK.Half.Life NA 1.332 hours 1compartment NA NA Rat Human +DTXSID4046527 Css NA 0.06661 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046527 Css NA 0.3861 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046527 Css NA 0.04805 mg/L PBTK NA 50% Rat Human +DTXSID4046527 Css NA 0.2292 mg/L PBTK NA 95% Rat Human +DTXSID4046529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046529 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046529 Vd NA 4.474 L/kg 1compartment NA NA Human Human DTXSID4046529 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046529 TK.Half.Life NA 2.984 hours 1compartment NA NA Human Human -DTXSID4046529 Css NA 0.03151 mg/L 3compartmentss NA 50% Human Human -DTXSID4046529 Css NA 0.286 mg/L 3compartmentss NA 95% Human Human -DTXSID4046529 Css NA 0.04077 mg/L PBTK NA 50% Human Human -DTXSID4046529 Css NA 0.2838 mg/L PBTK NA 95% Human Human -DTXSID4046529 Clint NA 19.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046529 Fup NA 0.328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046529 Vd NA 3.505 L/kg 1compartment NA NA Rat Human +DTXSID4046529 TK.Half.Life NA 2.827 hours 1compartment NA NA Human Human +DTXSID4046529 Css NA 0.01669 mg/L 3compartmentss NA 50% Human Human +DTXSID4046529 Css NA 0.1797 mg/L 3compartmentss NA 95% Human Human +DTXSID4046529 Css NA 0.0259 mg/L PBTK NA 50% Human Human +DTXSID4046529 Css NA 0.1976 mg/L PBTK NA 95% Human Human +DTXSID4046529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046529 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046529 Vd NA 4.498 L/kg 1compartment NA NA Rat Human DTXSID4046529 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046529 TK.Half.Life NA 1.672 hours 1compartment NA NA Rat Human -DTXSID4046529 Css NA 0.01662 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046529 Css NA 0.121 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046529 Css NA 0.02168 mg/L PBTK NA 50% Rat Human -DTXSID4046529 Css NA 0.1145 mg/L PBTK NA 95% Rat Human -DTXSID4046571 Clint NA 1.641 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046571 Fup NA 0.1752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046571 Vd NA 0.399 L/kg 1compartment NA NA Human Human +DTXSID4046529 TK.Half.Life NA 1.556 hours 1compartment NA NA Rat Human +DTXSID4046529 Css NA 0.002006 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046529 Css NA 0.0168 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046529 Css NA 0.003302 mg/L PBTK NA 50% Rat Human +DTXSID4046529 Css NA 0.01847 mg/L PBTK NA 95% Rat Human +DTXSID4046571 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046571 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046571 Vd NA 0.5108 L/kg 1compartment NA NA Human Human DTXSID4046571 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046571 TK.Half.Life NA 4.097 hours 1compartment NA NA Human Human -DTXSID4046571 Css NA 1.269 mg/L 3compartmentss NA 50% Human Human -DTXSID4046571 Css NA 6.157 mg/L 3compartmentss NA 95% Human Human -DTXSID4046571 Css NA 0.8338 mg/L PBTK NA 50% Human Human -DTXSID4046571 Css NA 3.808 mg/L PBTK NA 95% Human Human -DTXSID4046571 Clint NA 1.641 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046571 Fup NA 0.1752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046571 Vd NA 0.4012 L/kg 1compartment NA NA Rat Human +DTXSID4046571 TK.Half.Life NA 1.058 hours 1compartment NA NA Human Human +DTXSID4046571 Css NA 0.1698 mg/L 3compartmentss NA 50% Human Human +DTXSID4046571 Css NA 1.087 mg/L 3compartmentss NA 95% Human Human +DTXSID4046571 Css NA 0.123 mg/L PBTK NA 50% Human Human +DTXSID4046571 Css NA 0.7189 mg/L PBTK NA 95% Human Human +DTXSID4046571 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046571 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046571 Vd NA 0.5237 L/kg 1compartment NA NA Rat Human DTXSID4046571 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046571 TK.Half.Life NA 2.205 hours 1compartment NA NA Rat Human -DTXSID4046571 Css NA 0.5724 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046571 Css NA 1.981 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046571 Css NA 0.3576 mg/L PBTK NA 50% Rat Human -DTXSID4046571 Css NA 1.138 mg/L PBTK NA 95% Rat Human +DTXSID4046571 TK.Half.Life NA 0.6091 hours 1compartment NA NA Rat Human +DTXSID4046571 Css NA 0.01976 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046571 Css NA 0.09777 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046571 Css NA 0.01426 mg/L PBTK NA 50% Rat Human +DTXSID4046571 Css NA 0.06209 mg/L PBTK NA 95% Rat Human DTXSID4046573 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4046573 Fup NA 0.0624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046573 Vd NA 0.3773 L/kg 1compartment NA NA Human Human +DTXSID4046573 Vd NA 0.3566 L/kg 1compartment NA NA Human Human DTXSID4046573 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID4046573 TK.Half.Life NA 39.27 hours 1compartment NA NA Human Human -DTXSID4046573 Css NA 16.86 mg/L 3compartmentss NA 50% Human Human -DTXSID4046573 Css NA 75.69 mg/L 3compartmentss NA 95% Human Human -DTXSID4046573 Css NA 10.66 mg/L PBTK NA 50% Human Human -DTXSID4046573 Css NA 44.82 mg/L PBTK NA 95% Human Human +DTXSID4046573 TK.Half.Life NA 37.09 hours 1compartment NA NA Human Human +DTXSID4046573 Css NA 16.51 mg/L 3compartmentss NA 50% Human Human +DTXSID4046573 Css NA 73.03 mg/L 3compartmentss NA 95% Human Human +DTXSID4046573 Css NA 10.37 mg/L PBTK NA 50% Human Human +DTXSID4046573 Css NA 43.5 mg/L PBTK NA 95% Human Human DTXSID4046573 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4046573 Fup NA 0.0624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046573 Vd NA 0.3575 L/kg 1compartment NA NA Rat Human +DTXSID4046573 Vd NA 0.3401 L/kg 1compartment NA NA Rat Human DTXSID4046573 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4046573 TK.Half.Life NA 12.64 hours 1compartment NA NA Rat Human -DTXSID4046573 Css NA 4.712 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046573 Css NA 18.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046573 Css NA 2.79 mg/L PBTK NA 50% Rat Human -DTXSID4046573 Css NA 10.27 mg/L PBTK NA 95% Rat Human -DTXSID4046575 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046575 Fup NA 0.3294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046575 Vd NA 0.7222 L/kg 1compartment NA NA Human Human +DTXSID4046573 TK.Half.Life NA 12.03 hours 1compartment NA NA Rat Human +DTXSID4046573 Css NA 1.078 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046573 Css NA 4.026 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046573 Css NA 0.6564 mg/L PBTK NA 50% Rat Human +DTXSID4046573 Css NA 2.309 mg/L PBTK NA 95% Rat Human +DTXSID4046575 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046575 Fup 0.506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046575 Vd NA 0.9253 L/kg 1compartment NA NA Human Human DTXSID4046575 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4046575 TK.Half.Life NA 14.54 hours 1compartment NA NA Human Human -DTXSID4046575 Css NA 2.232 mg/L 3compartmentss NA 50% Human Human -DTXSID4046575 Css NA 8.982 mg/L 3compartmentss NA 95% Human Human -DTXSID4046575 Css NA 1.648 mg/L PBTK NA 50% Human Human -DTXSID4046575 Css NA 5.779 mg/L PBTK NA 95% Human Human -DTXSID4046575 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046575 Fup NA 0.3294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046575 Vd NA 0.6693 L/kg 1compartment NA NA Rat Human +DTXSID4046575 TK.Half.Life NA 12.29 hours 1compartment NA NA Human Human +DTXSID4046575 Css NA 1.373 mg/L 3compartmentss NA 50% Human Human +DTXSID4046575 Css NA 7.537 mg/L 3compartmentss NA 95% Human Human +DTXSID4046575 Css NA 1.113 mg/L PBTK NA 50% Human Human +DTXSID4046575 Css NA 4.913 mg/L PBTK NA 95% Human Human +DTXSID4046575 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046575 Fup 0.506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046575 Vd NA 0.8606 L/kg 1compartment NA NA Rat Human DTXSID4046575 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046575 TK.Half.Life NA 4.51 hours 1compartment NA NA Rat Human -DTXSID4046575 Css NA 0.6146 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046575 Css NA 2.168 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046575 Css NA 0.432 mg/L PBTK NA 50% Rat Human -DTXSID4046575 Css NA 1.289 mg/L PBTK NA 95% Rat Human -DTXSID4046577 Clint NA 0.4752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046577 Fup NA 0.0582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046577 Vd NA 0.7579 L/kg 1compartment NA NA Human Human -DTXSID4046577 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID4046577 TK.Half.Life NA 49.06 hours 1compartment NA NA Human Human -DTXSID4046577 Css NA 10.18 mg/L 3compartmentss NA 50% Human Human -DTXSID4046577 Css NA 49.04 mg/L 3compartmentss NA 95% Human Human -DTXSID4046577 Css NA 6.36 mg/L PBTK NA 50% Human Human -DTXSID4046577 Css NA 28.99 mg/L PBTK NA 95% Human Human -DTXSID4046577 Clint NA 0.4752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046577 Fup NA 0.0582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046577 Vd NA 0.5931 L/kg 1compartment NA NA Rat Human -DTXSID4046577 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4046577 TK.Half.Life NA 16.13 hours 1compartment NA NA Rat Human -DTXSID4046577 Css NA 3.79 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046577 Css NA 15.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046577 Css NA 2.233 mg/L PBTK NA 50% Rat Human -DTXSID4046577 Css NA 8.513 mg/L PBTK NA 95% Rat Human -DTXSID4046579 Clint NA 12.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046579 Fup NA 0.7181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046579 Vd NA 0.5238 L/kg 1compartment NA NA Human Human +DTXSID4046575 TK.Half.Life NA 3.786 hours 1compartment NA NA Rat Human +DTXSID4046575 Css NA 0.08466 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046575 Css NA 0.4201 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046575 Css NA 0.06834 mg/L PBTK NA 50% Rat Human +DTXSID4046575 Css NA 0.2624 mg/L PBTK NA 95% Rat Human +DTXSID4046577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046577 Fup 0.097 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046577 Vd NA 0.2272 L/kg 1compartment NA NA Human Human +DTXSID4046577 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046577 TK.Half.Life NA 0.6118 hours 1compartment NA NA Human Human +DTXSID4046577 Css NA 0.1603 mg/L 3compartmentss NA 50% Human Human +DTXSID4046577 Css NA 1.429 mg/L 3compartmentss NA 95% Human Human +DTXSID4046577 Css NA 0.09668 mg/L PBTK NA 50% Human Human +DTXSID4046577 Css NA 0.8412 mg/L PBTK NA 95% Human Human +DTXSID4046577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046577 Fup 0.097 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046577 Vd NA 0.227 L/kg 1compartment NA NA Rat Human +DTXSID4046577 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046577 TK.Half.Life NA 0.3629 hours 1compartment NA NA Rat Human +DTXSID4046577 Css NA 0.001684 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046577 Css NA 0.01364 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046577 Css NA 0.0009537 mg/L PBTK NA 50% Rat Human +DTXSID4046577 Css NA 0.007542 mg/L PBTK NA 95% Rat Human +DTXSID4046579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046579 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046579 Vd NA 0.5575 L/kg 1compartment NA NA Human Human DTXSID4046579 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046579 TK.Half.Life NA 0.539 hours 1compartment NA NA Human Human -DTXSID4046579 Css NA 0.0571 mg/L 3compartmentss NA 50% Human Human -DTXSID4046579 Css NA 0.5073 mg/L 3compartmentss NA 95% Human Human -DTXSID4046579 Css NA 0.04216 mg/L PBTK NA 50% Human Human -DTXSID4046579 Css NA 0.3325 mg/L PBTK NA 95% Human Human -DTXSID4046579 Clint NA 12.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046579 Fup NA 0.7181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046579 Vd NA 0.54 L/kg 1compartment NA NA Rat Human +DTXSID4046579 TK.Half.Life NA 4.495 hours 1compartment NA NA Human Human +DTXSID4046579 Css NA 0.9266 mg/L 3compartmentss NA 50% Human Human +DTXSID4046579 Css NA 5.096 mg/L 3compartmentss NA 95% Human Human +DTXSID4046579 Css NA 0.7036 mg/L PBTK NA 50% Human Human +DTXSID4046579 Css NA 3.239 mg/L PBTK NA 95% Human Human +DTXSID4046579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046579 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046579 Vd NA 0.5751 L/kg 1compartment NA NA Rat Human DTXSID4046579 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046579 TK.Half.Life NA 0.2797 hours 1compartment NA NA Rat Human -DTXSID4046579 Css NA 0.02809 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046579 Css NA 0.2241 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046579 Css NA 0.02037 mg/L PBTK NA 50% Rat Human -DTXSID4046579 Css NA 0.1369 mg/L PBTK NA 95% Rat Human -DTXSID4046600 Clint NA 9.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046600 Fup NA 0.5191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046600 Vd NA 0.4123 L/kg 1compartment NA NA Human Human +DTXSID4046579 TK.Half.Life NA 1.579 hours 1compartment NA NA Rat Human +DTXSID4046579 Css NA 0.02366 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046579 Css NA 0.1513 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046579 Css NA 0.01752 mg/L PBTK NA 50% Rat Human +DTXSID4046579 Css NA 0.09408 mg/L PBTK NA 95% Rat Human +DTXSID4046600 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046600 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046600 Vd NA 0.3957 L/kg 1compartment NA NA Human Human DTXSID4046600 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046600 TK.Half.Life NA 0.5645 hours 1compartment NA NA Human Human -DTXSID4046600 Css NA 0.09157 mg/L 3compartmentss NA 50% Human Human -DTXSID4046600 Css NA 0.6979 mg/L 3compartmentss NA 95% Human Human -DTXSID4046600 Css NA 0.06504 mg/L PBTK NA 50% Human Human -DTXSID4046600 Css NA 0.453 mg/L PBTK NA 95% Human Human -DTXSID4046600 Clint NA 9.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046600 Fup NA 0.5191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046600 Vd NA 0.4222 L/kg 1compartment NA NA Rat Human +DTXSID4046600 TK.Half.Life NA 5.377 hours 1compartment NA NA Human Human +DTXSID4046600 Css NA 1.585 mg/L 3compartmentss NA 50% Human Human +DTXSID4046600 Css NA 7.328 mg/L 3compartmentss NA 95% Human Human +DTXSID4046600 Css NA 1.118 mg/L PBTK NA 50% Human Human +DTXSID4046600 Css NA 4.54 mg/L PBTK NA 95% Human Human +DTXSID4046600 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046600 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046600 Vd NA 0.4047 L/kg 1compartment NA NA Rat Human DTXSID4046600 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046600 TK.Half.Life NA 0.3052 hours 1compartment NA NA Rat Human -DTXSID4046600 Css NA 0.04762 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046600 Css NA 0.3062 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046600 Css NA 0.03228 mg/L PBTK NA 50% Rat Human -DTXSID4046600 Css NA 0.1824 mg/L PBTK NA 95% Rat Human -DTXSID4046602 Clint NA 0.3174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046602 Fup NA 0.4475 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046602 Vd NA 0.439 L/kg 1compartment NA NA Human Human +DTXSID4046600 TK.Half.Life NA 1.875 hours 1compartment NA NA Rat Human +DTXSID4046600 Css NA 0.1011 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046600 Css NA 0.4046 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046600 Css NA 0.07014 mg/L PBTK NA 50% Rat Human +DTXSID4046600 Css NA 0.242 mg/L PBTK NA 95% Rat Human +DTXSID4046602 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046602 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046602 Vd NA 0.5557 L/kg 1compartment NA NA Human Human DTXSID4046602 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046602 TK.Half.Life NA 4.203 hours 1compartment NA NA Human Human -DTXSID4046602 Css NA 1.096 mg/L 3compartmentss NA 50% Human Human -DTXSID4046602 Css NA 5.183 mg/L 3compartmentss NA 95% Human Human -DTXSID4046602 Css NA 0.7795 mg/L PBTK NA 50% Human Human -DTXSID4046602 Css NA 3.202 mg/L PBTK NA 95% Human Human -DTXSID4046602 Clint NA 0.3174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046602 Fup NA 0.4475 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046602 Vd NA 0.4519 L/kg 1compartment NA NA Rat Human +DTXSID4046602 TK.Half.Life NA 5.184 hours 1compartment NA NA Human Human +DTXSID4046602 Css NA 0.996 mg/L 3compartmentss NA 50% Human Human +DTXSID4046602 Css NA 6.41 mg/L 3compartmentss NA 95% Human Human +DTXSID4046602 Css NA 0.7606 mg/L PBTK NA 50% Human Human +DTXSID4046602 Css NA 3.975 mg/L PBTK NA 95% Human Human +DTXSID4046602 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046602 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046602 Vd NA 0.5741 L/kg 1compartment NA NA Rat Human DTXSID4046602 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046602 TK.Half.Life NA 1.781 hours 1compartment NA NA Rat Human -DTXSID4046602 Css NA 0.3694 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046602 Css NA 1.497 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046602 Css NA 0.2496 mg/L PBTK NA 50% Rat Human -DTXSID4046602 Css NA 0.8685 mg/L PBTK NA 95% Rat Human -DTXSID4046604 Clint NA 1.477 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046604 Fup NA 0.1858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046604 Vd NA 1.544 L/kg 1compartment NA NA Human Human -DTXSID4046604 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4046604 TK.Half.Life NA 15.65 hours 1compartment NA NA Human Human -DTXSID4046604 Css NA 1.018 mg/L 3compartmentss NA 50% Human Human -DTXSID4046604 Css NA 5.011 mg/L 3compartmentss NA 95% Human Human -DTXSID4046604 Css NA 0.8252 mg/L PBTK NA 50% Human Human -DTXSID4046604 Css NA 3.474 mg/L PBTK NA 95% Human Human -DTXSID4046604 Clint NA 1.477 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046604 Fup NA 0.1858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046604 Vd NA 1.539 L/kg 1compartment NA NA Rat Human +DTXSID4046602 TK.Half.Life NA 1.825 hours 1compartment NA NA Rat Human +DTXSID4046602 Css NA 0.02626 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046602 Css NA 0.1881 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046602 Css NA 0.01927 mg/L PBTK NA 50% Rat Human +DTXSID4046602 Css NA 0.1161 mg/L PBTK NA 95% Rat Human +DTXSID4046604 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046604 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046604 Vd NA 0.9118 L/kg 1compartment NA NA Human Human +DTXSID4046604 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046604 TK.Half.Life NA 2.147 hours 1compartment NA NA Human Human +DTXSID4046604 Css NA 0.09751 mg/L 3compartmentss NA 50% Human Human +DTXSID4046604 Css NA 0.7275 mg/L 3compartmentss NA 95% Human Human +DTXSID4046604 Css NA 0.07496 mg/L PBTK NA 50% Human Human +DTXSID4046604 Css NA 0.4924 mg/L PBTK NA 95% Human Human +DTXSID4046604 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046604 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046604 Vd NA 0.9211 L/kg 1compartment NA NA Rat Human DTXSID4046604 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046604 TK.Half.Life NA 8.282 hours 1compartment NA NA Rat Human -DTXSID4046604 Css NA 0.4354 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046604 Css NA 1.701 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046604 Css NA 0.3428 mg/L PBTK NA 50% Rat Human -DTXSID4046604 Css NA 1.075 mg/L PBTK NA 95% Rat Human -DTXSID4046606 Clint NA 136.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046606 Fup NA 0.3621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046606 Vd NA 3.283 L/kg 1compartment NA NA Human Human -DTXSID4046606 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046606 TK.Half.Life NA 4.409 hours 1compartment NA NA Human Human -DTXSID4046606 Css NA 0.06612 mg/L 3compartmentss NA 50% Human Human -DTXSID4046606 Css NA 0.4263 mg/L 3compartmentss NA 95% Human Human -DTXSID4046606 Css NA 0.04801 mg/L PBTK NA 50% Human Human -DTXSID4046606 Css NA 0.2959 mg/L PBTK NA 95% Human Human -DTXSID4046606 Clint NA 136.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046606 Fup NA 0.3621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046606 Vd NA 2.516 L/kg 1compartment NA NA Rat Human -DTXSID4046606 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046606 TK.Half.Life NA 1.104 hours 1compartment NA NA Rat Human -DTXSID4046606 Css NA 0.037 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046606 Css NA 0.206 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046606 Css NA 0.02571 mg/L PBTK NA 50% Rat Human -DTXSID4046606 Css NA 0.1376 mg/L PBTK NA 95% Rat Human -DTXSID4046608 Clint NA 33.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046608 Fup NA 0.1352 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046608 Vd NA 3.433 L/kg 1compartment NA NA Human Human +DTXSID4046604 TK.Half.Life NA 1.242 hours 1compartment NA NA Rat Human +DTXSID4046604 Css NA 0.0009214 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046604 Css NA 0.005903 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046604 Css NA 0.0006838 mg/L PBTK NA 50% Rat Human +DTXSID4046604 Css NA 0.003819 mg/L PBTK NA 95% Rat Human +DTXSID4046608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046608 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046608 Vd NA 0.8359 L/kg 1compartment NA NA Human Human DTXSID4046608 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046608 TK.Half.Life NA 5.279 hours 1compartment NA NA Human Human -DTXSID4046608 Css NA 0.1051 mg/L 3compartmentss NA 50% Human Human -DTXSID4046608 Css NA 0.788 mg/L 3compartmentss NA 95% Human Human -DTXSID4046608 Css NA 0.09115 mg/L PBTK NA 50% Human Human -DTXSID4046608 Css NA 0.618 mg/L PBTK NA 95% Human Human -DTXSID4046608 Clint NA 33.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046608 Fup NA 0.1352 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046608 Vd NA 3.017 L/kg 1compartment NA NA Rat Human +DTXSID4046608 TK.Half.Life NA 3.239 hours 1compartment NA NA Human Human +DTXSID4046608 Css NA 0.3942 mg/L 3compartmentss NA 50% Human Human +DTXSID4046608 Css NA 2.529 mg/L 3compartmentss NA 95% Human Human +DTXSID4046608 Css NA 0.2755 mg/L PBTK NA 50% Human Human +DTXSID4046608 Css NA 1.624 mg/L PBTK NA 95% Human Human +DTXSID4046608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046608 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046608 Vd NA 0.8337 L/kg 1compartment NA NA Rat Human DTXSID4046608 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046608 TK.Half.Life NA 1.931 hours 1compartment NA NA Rat Human -DTXSID4046608 Css NA 0.0571 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046608 Css NA 0.3426 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046608 Css NA 0.04835 mg/L PBTK NA 50% Rat Human -DTXSID4046608 Css NA 0.26 mg/L PBTK NA 95% Rat Human +DTXSID4046608 TK.Half.Life NA 1.924 hours 1compartment NA NA Rat Human +DTXSID4046608 Css NA 0.0472 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046608 Css NA 0.2135 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046608 Css NA 0.03255 mg/L PBTK NA 50% Rat Human +DTXSID4046608 Css NA 0.134 mg/L PBTK NA 95% Rat Human DTXSID4046652 Clint NA 18.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4046652 Fup NA 0.827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046652 Vd NA 1.653 L/kg 1compartment NA NA Human Human +DTXSID4046652 Vd NA 0.6417 L/kg 1compartment NA NA Human Human DTXSID4046652 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046652 TK.Half.Life NA 1.175 hours 1compartment NA NA Human Human -DTXSID4046652 Css NA 0.02875 mg/L 3compartmentss NA 50% Human Human -DTXSID4046652 Css NA 0.2757 mg/L 3compartmentss NA 95% Human Human -DTXSID4046652 Css NA 0.02727 mg/L PBTK NA 50% Human Human -DTXSID4046652 Css NA 0.2089 mg/L PBTK NA 95% Human Human +DTXSID4046652 TK.Half.Life NA 0.5275 hours 1compartment NA NA Human Human +DTXSID4046652 Css NA 0.02509 mg/L 3compartmentss NA 50% Human Human +DTXSID4046652 Css NA 0.2819 mg/L 3compartmentss NA 95% Human Human +DTXSID4046652 Css NA 0.01969 mg/L PBTK NA 50% Human Human +DTXSID4046652 Css NA 0.1938 mg/L PBTK NA 95% Human Human DTXSID4046652 Clint NA 18.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4046652 Fup NA 0.827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046652 Vd NA 1.633 L/kg 1compartment NA NA Rat Human +DTXSID4046652 Vd NA 0.6808 L/kg 1compartment NA NA Rat Human DTXSID4046652 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046652 TK.Half.Life NA 0.5805 hours 1compartment NA NA Rat Human -DTXSID4046652 Css NA 0.014 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046652 Css NA 0.1299 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046652 Css NA 0.01333 mg/L PBTK NA 50% Rat Human -DTXSID4046652 Css NA 0.09348 mg/L PBTK NA 95% Rat Human -DTXSID4046654 Clint NA 1.981 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046654 Fup NA 0.5246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046654 Vd NA 0.3918 L/kg 1compartment NA NA Human Human +DTXSID4046652 TK.Half.Life NA 0.2718 hours 1compartment NA NA Rat Human +DTXSID4046652 Css NA 0.000863 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046652 Css NA 0.01144 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046652 Css NA 0.000669 mg/L PBTK NA 50% Rat Human +DTXSID4046652 Css NA 0.007478 mg/L PBTK NA 95% Rat Human +DTXSID4046654 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046654 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046654 Vd NA 0.3507 L/kg 1compartment NA NA Human Human DTXSID4046654 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046654 TK.Half.Life NA 1.291 hours 1compartment NA NA Human Human -DTXSID4046654 Css NA 0.361 mg/L 3compartmentss NA 50% Human Human -DTXSID4046654 Css NA 2.306 mg/L 3compartmentss NA 95% Human Human -DTXSID4046654 Css NA 0.2547 mg/L PBTK NA 50% Human Human -DTXSID4046654 Css NA 1.429 mg/L PBTK NA 95% Human Human -DTXSID4046654 Clint NA 1.981 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046654 Fup NA 0.5246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046654 Vd NA 0.4115 L/kg 1compartment NA NA Rat Human +DTXSID4046654 TK.Half.Life NA 5.523 hours 1compartment NA NA Human Human +DTXSID4046654 Css NA 1.032 mg/L 3compartmentss NA 50% Human Human +DTXSID4046654 Css NA 4.577 mg/L 3compartmentss NA 95% Human Human +DTXSID4046654 Css NA 0.702 mg/L PBTK NA 50% Human Human +DTXSID4046654 Css NA 2.814 mg/L PBTK NA 95% Human Human +DTXSID4046654 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046654 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046654 Vd NA 0.3668 L/kg 1compartment NA NA Rat Human DTXSID4046654 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046654 TK.Half.Life NA 0.7125 hours 1compartment NA NA Rat Human -DTXSID4046654 Css NA 0.1609 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046654 Css NA 0.8257 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046654 Css NA 0.1074 mg/L PBTK NA 50% Rat Human -DTXSID4046654 Css NA 0.4777 mg/L PBTK NA 95% Rat Human -DTXSID4046656 Clint NA 90.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046656 Fup NA 0.513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046656 Vd NA 0.524 L/kg 1compartment NA NA Human Human +DTXSID4046654 TK.Half.Life NA 1.968 hours 1compartment NA NA Rat Human +DTXSID4046654 Css NA 0.005606 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046654 Css NA 0.02535 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046654 Css NA 0.00363 mg/L PBTK NA 50% Rat Human +DTXSID4046654 Css NA 0.015 mg/L PBTK NA 95% Rat Human +DTXSID4046656 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046656 Fup 0.57 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046656 Vd NA 0.4952 L/kg 1compartment NA NA Human Human DTXSID4046656 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046656 TK.Half.Life NA 0.4166 hours 1compartment NA NA Human Human -DTXSID4046656 Css NA 0.01056 mg/L 3compartmentss NA 50% Human Human -DTXSID4046656 Css NA 0.09796 mg/L 3compartmentss NA 95% Human Human -DTXSID4046656 Css NA 0.00765 mg/L PBTK NA 50% Human Human -DTXSID4046656 Css NA 0.06565 mg/L PBTK NA 95% Human Human -DTXSID4046656 Clint NA 90.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046656 Fup NA 0.513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046656 Vd NA 0.5371 L/kg 1compartment NA NA Rat Human +DTXSID4046656 TK.Half.Life NA 5.622 hours 1compartment NA NA Human Human +DTXSID4046656 Css NA 0.7498 mg/L 3compartmentss NA 50% Human Human +DTXSID4046656 Css NA 5.189 mg/L 3compartmentss NA 95% Human Human +DTXSID4046656 Css NA 0.5546 mg/L PBTK NA 50% Human Human +DTXSID4046656 Css NA 3.21 mg/L PBTK NA 95% Human Human +DTXSID4046656 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046656 Fup 0.57 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046656 Vd NA 0.5181 L/kg 1compartment NA NA Rat Human DTXSID4046656 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046656 TK.Half.Life NA 0.1941 hours 1compartment NA NA Rat Human -DTXSID4046656 Css NA 0.005733 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046656 Css NA 0.04586 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046656 Css NA 0.004036 mg/L PBTK NA 50% Rat Human -DTXSID4046656 Css NA 0.02821 mg/L PBTK NA 95% Rat Human -DTXSID4046658 Clint NA 137.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046658 Fup NA 0.0545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046658 Vd NA 0.578 L/kg 1compartment NA NA Human Human +DTXSID4046656 TK.Half.Life NA 2.004 hours 1compartment NA NA Rat Human +DTXSID4046656 Css NA 0.004004 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046656 Css NA 0.02741 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046656 Css NA 0.002816 mg/L PBTK NA 50% Rat Human +DTXSID4046656 Css NA 0.01617 mg/L PBTK NA 95% Rat Human +DTXSID4046658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046658 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046658 Vd NA 1.191 L/kg 1compartment NA NA Human Human DTXSID4046658 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046658 TK.Half.Life NA 0.8196 hours 1compartment NA NA Human Human -DTXSID4046658 Css NA 0.09078 mg/L 3compartmentss NA 50% Human Human -DTXSID4046658 Css NA 0.8218 mg/L 3compartmentss NA 95% Human Human -DTXSID4046658 Css NA 0.05572 mg/L PBTK NA 50% Human Human -DTXSID4046658 Css NA 0.4867 mg/L PBTK NA 95% Human Human -DTXSID4046658 Clint NA 137.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046658 Fup NA 0.0545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046658 Vd NA 0.4588 L/kg 1compartment NA NA Rat Human +DTXSID4046658 TK.Half.Life NA 2.032 hours 1compartment NA NA Human Human +DTXSID4046658 Css NA 0.09768 mg/L 3compartmentss NA 50% Human Human +DTXSID4046658 Css NA 0.7052 mg/L 3compartmentss NA 95% Human Human +DTXSID4046658 Css NA 0.06886 mg/L PBTK NA 50% Human Human +DTXSID4046658 Css NA 0.4635 mg/L PBTK NA 95% Human Human +DTXSID4046658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046658 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046658 Vd NA 0.9428 L/kg 1compartment NA NA Rat Human DTXSID4046658 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046658 TK.Half.Life NA 0.3378 hours 1compartment NA NA Rat Human -DTXSID4046658 Css NA 0.05258 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046658 Css NA 0.3691 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046658 Css NA 0.03008 mg/L PBTK NA 50% Rat Human -DTXSID4046658 Css NA 0.2072 mg/L PBTK NA 95% Rat Human -DTXSID4046733 Clint NA 15.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046733 Fup NA 0.6882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046733 Vd NA 4.793 L/kg 1compartment NA NA Human Human +DTXSID4046658 TK.Half.Life NA 0.8295 hours 1compartment NA NA Rat Human +DTXSID4046658 Css NA 0.004748 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046658 Css NA 0.03721 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046658 Css NA 0.003311 mg/L PBTK NA 50% Rat Human +DTXSID4046658 Css NA 0.02369 mg/L PBTK NA 95% Rat Human +DTXSID4046733 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046733 Fup 0.606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046733 Vd NA 0.6873 L/kg 1compartment NA NA Human Human DTXSID4046733 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046733 TK.Half.Life NA 3.134 hours 1compartment NA NA Human Human -DTXSID4046733 Css NA 0.02426 mg/L 3compartmentss NA 50% Human Human -DTXSID4046733 Css NA 0.3359 mg/L 3compartmentss NA 95% Human Human -DTXSID4046733 Css NA 0.0358 mg/L PBTK NA 50% Human Human -DTXSID4046733 Css NA 0.3111 mg/L PBTK NA 95% Human Human -DTXSID4046733 Clint NA 15.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046733 Fup NA 0.6882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046733 Vd NA 4.908 L/kg 1compartment NA NA Rat Human +DTXSID4046733 TK.Half.Life NA 1.024 hours 1compartment NA NA Human Human +DTXSID4046733 Css NA 0.1117 mg/L 3compartmentss NA 50% Human Human +DTXSID4046733 Css NA 1 mg/L 3compartmentss NA 95% Human Human +DTXSID4046733 Css NA 0.08731 mg/L PBTK NA 50% Human Human +DTXSID4046733 Css NA 0.6593 mg/L PBTK NA 95% Human Human +DTXSID4046733 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046733 Fup 0.606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046733 Vd NA 0.6961 L/kg 1compartment NA NA Rat Human DTXSID4046733 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046733 TK.Half.Life NA 1.735 hours 1compartment NA NA Rat Human -DTXSID4046733 Css NA 0.01187 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046733 Css NA 0.1521 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046733 Css NA 0.01797 mg/L PBTK NA 50% Rat Human -DTXSID4046733 Css NA 0.1279 mg/L PBTK NA 95% Rat Human -DTXSID4046735 Clint NA 0.4638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046735 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046735 Vd NA 0.5071 L/kg 1compartment NA NA Human Human -DTXSID4046735 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID4046735 TK.Half.Life NA 76.58 hours 1compartment NA NA Human Human -DTXSID4046735 Css NA 25.25 mg/L 3compartmentss NA 50% Human Human -DTXSID4046735 Css NA 157.5 mg/L 3compartmentss NA 95% Human Human -DTXSID4046735 Css NA 15.17 mg/L PBTK NA 50% Human Human -DTXSID4046735 Css NA 91.4 mg/L PBTK NA 95% Human Human -DTXSID4046735 Clint NA 0.4638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046735 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046735 Vd NA 0.3991 L/kg 1compartment NA NA Rat Human -DTXSID4046735 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID4046735 TK.Half.Life NA 26.15 hours 1compartment NA NA Rat Human -DTXSID4046735 Css NA 9.471 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046735 Css NA 54.27 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046735 Css NA 5.308 mg/L PBTK NA 50% Rat Human -DTXSID4046735 Css NA 29.53 mg/L PBTK NA 95% Rat Human -DTXSID4046737 Clint NA 8.921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046737 Fup NA 0.0242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046737 Vd NA 1.534 L/kg 1compartment NA NA Human Human -DTXSID4046737 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4046737 TK.Half.Life NA 27.48 hours 1compartment NA NA Human Human -DTXSID4046737 Css NA 2.944 mg/L 3compartmentss NA 50% Human Human -DTXSID4046737 Css NA 22.67 mg/L 3compartmentss NA 95% Human Human -DTXSID4046737 Css NA 1.872 mg/L PBTK NA 50% Human Human -DTXSID4046737 Css NA 14.03 mg/L PBTK NA 95% Human Human -DTXSID4046737 Clint NA 8.921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046737 Fup NA 0.0242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046737 Vd NA 1.139 L/kg 1compartment NA NA Rat Human -DTXSID4046737 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4046737 TK.Half.Life NA 10.28 hours 1compartment NA NA Rat Human -DTXSID4046737 Css NA 1.598 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046737 Css NA 10.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046737 Css NA 0.948 mg/L PBTK NA 50% Rat Human -DTXSID4046737 Css NA 5.791 mg/L PBTK NA 95% Rat Human -DTXSID4046739 Clint NA 65.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046739 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046739 Vd NA 2.529 L/kg 1compartment NA NA Human Human +DTXSID4046733 TK.Half.Life NA 0.5585 hours 1compartment NA NA Rat Human +DTXSID4046733 Css NA 0.01273 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046733 Css NA 0.09649 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046733 Css NA 0.01012 mg/L PBTK NA 50% Rat Human +DTXSID4046733 Css NA 0.06067 mg/L PBTK NA 95% Rat Human +DTXSID4046737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046737 Fup 0.0846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046737 Vd NA 0.7759 L/kg 1compartment NA NA Human Human +DTXSID4046737 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046737 TK.Half.Life NA 2.128 hours 1compartment NA NA Human Human +DTXSID4046737 Css NA 0.254 mg/L 3compartmentss NA 50% Human Human +DTXSID4046737 Css NA 2.178 mg/L 3compartmentss NA 95% Human Human +DTXSID4046737 Css NA 0.185 mg/L PBTK NA 50% Human Human +DTXSID4046737 Css NA 1.442 mg/L PBTK NA 95% Human Human +DTXSID4046737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046737 Fup 0.0846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046737 Vd NA 0.7274 L/kg 1compartment NA NA Rat Human +DTXSID4046737 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046737 TK.Half.Life NA 1.209 hours 1compartment NA NA Rat Human +DTXSID4046737 Css NA 0.0119 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046737 Css NA 0.1145 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046737 Css NA 0.00856 mg/L PBTK NA 50% Rat Human +DTXSID4046737 Css NA 0.07265 mg/L PBTK NA 95% Rat Human +DTXSID4046739 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046739 Fup 0.622 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046739 Vd NA 0.7608 L/kg 1compartment NA NA Human Human DTXSID4046739 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046739 TK.Half.Life NA 1.166 hours 1compartment NA NA Human Human -DTXSID4046739 Css NA 0.006246 mg/L 3compartmentss NA 50% Human Human -DTXSID4046739 Css NA 0.09303 mg/L 3compartmentss NA 95% Human Human -DTXSID4046739 Css NA 0.006788 mg/L PBTK NA 50% Human Human -DTXSID4046739 Css NA 0.08301 mg/L PBTK NA 95% Human Human -DTXSID4046739 Clint NA 65.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046739 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046739 Vd NA 2.575 L/kg 1compartment NA NA Rat Human +DTXSID4046739 TK.Half.Life NA 0.6756 hours 1compartment NA NA Human Human +DTXSID4046739 Css NA 0.0323 mg/L 3compartmentss NA 50% Human Human +DTXSID4046739 Css NA 0.3521 mg/L 3compartmentss NA 95% Human Human +DTXSID4046739 Css NA 0.02599 mg/L PBTK NA 50% Human Human +DTXSID4046739 Css NA 0.237 mg/L PBTK NA 95% Human Human +DTXSID4046739 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046739 Fup 0.622 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046739 Vd NA 0.7578 L/kg 1compartment NA NA Rat Human DTXSID4046739 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046739 TK.Half.Life NA 0.5436 hours 1compartment NA NA Rat Human -DTXSID4046739 Css NA 0.003136 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046739 Css NA 0.03978 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046739 Css NA 0.003442 mg/L PBTK NA 50% Rat Human -DTXSID4046739 Css NA 0.03492 mg/L PBTK NA 95% Rat Human -DTXSID4046783 Clint NA 10.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046783 Fup NA 0.0682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046783 Vd NA 2.161 L/kg 1compartment NA NA Human Human -DTXSID4046783 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4046783 TK.Half.Life NA 17.91 hours 1compartment NA NA Human Human -DTXSID4046783 Css NA 1.099 mg/L 3compartmentss NA 50% Human Human -DTXSID4046783 Css NA 7.054 mg/L 3compartmentss NA 95% Human Human -DTXSID4046783 Css NA 0.7357 mg/L PBTK NA 50% Human Human -DTXSID4046783 Css NA 4.492 mg/L PBTK NA 95% Human Human -DTXSID4046783 Clint NA 10.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046783 Fup NA 0.0682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046783 Vd NA 1.629 L/kg 1compartment NA NA Rat Human +DTXSID4046739 TK.Half.Life NA 0.3326 hours 1compartment NA NA Rat Human +DTXSID4046739 Css NA 0.003924 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046739 Css NA 0.0354 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046739 Css NA 0.003167 mg/L PBTK NA 50% Rat Human +DTXSID4046739 Css NA 0.02301 mg/L PBTK NA 95% Rat Human +DTXSID4046783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046783 Fup 0.0621 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046783 Vd NA 2.058 L/kg 1compartment NA NA Human Human +DTXSID4046783 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046783 TK.Half.Life NA 9.75 hours 1compartment NA NA Human Human +DTXSID4046783 Css NA 0.5888 mg/L 3compartmentss NA 50% Human Human +DTXSID4046783 Css NA 4.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4046783 Css NA 0.3903 mg/L PBTK NA 50% Human Human +DTXSID4046783 Css NA 2.668 mg/L PBTK NA 95% Human Human +DTXSID4046783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046783 Fup 0.0621 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046783 Vd NA 1.55 L/kg 1compartment NA NA Rat Human DTXSID4046783 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046783 TK.Half.Life NA 5.419 hours 1compartment NA NA Rat Human -DTXSID4046783 Css NA 0.6009 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046783 Css NA 2.736 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046783 Css NA 0.3824 mg/L PBTK NA 50% Rat Human -DTXSID4046783 Css NA 1.67 mg/L PBTK NA 95% Rat Human -DTXSID4046785 Clint NA 19.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046785 Fup NA 0.5214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046785 Vd NA 3.542 L/kg 1compartment NA NA Human Human +DTXSID4046783 TK.Half.Life NA 3.145 hours 1compartment NA NA Rat Human +DTXSID4046783 Css NA 0.07452 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046783 Css NA 0.4189 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046783 Css NA 0.04873 mg/L PBTK NA 50% Rat Human +DTXSID4046783 Css NA 0.2617 mg/L PBTK NA 95% Rat Human +DTXSID4046785 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046785 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046785 Vd NA 1.768 L/kg 1compartment NA NA Human Human DTXSID4046785 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046785 TK.Half.Life NA 2.74 hours 1compartment NA NA Human Human -DTXSID4046785 Css NA 0.02853 mg/L 3compartmentss NA 50% Human Human -DTXSID4046785 Css NA 0.3003 mg/L 3compartmentss NA 95% Human Human -DTXSID4046785 Css NA 0.0342 mg/L PBTK NA 50% Human Human -DTXSID4046785 Css NA 0.2657 mg/L PBTK NA 95% Human Human -DTXSID4046785 Clint NA 19.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046785 Fup NA 0.5214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046785 Vd NA 3.556 L/kg 1compartment NA NA Rat Human +DTXSID4046785 TK.Half.Life NA 2.942 hours 1compartment NA NA Human Human +DTXSID4046785 Css NA 0.1129 mg/L 3compartmentss NA 50% Human Human +DTXSID4046785 Css NA 0.8927 mg/L 3compartmentss NA 95% Human Human +DTXSID4046785 Css NA 0.1035 mg/L PBTK NA 50% Human Human +DTXSID4046785 Css NA 0.6645 mg/L PBTK NA 95% Human Human +DTXSID4046785 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046785 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046785 Vd NA 1.784 L/kg 1compartment NA NA Rat Human DTXSID4046785 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046785 TK.Half.Life NA 1.431 hours 1compartment NA NA Rat Human -DTXSID4046785 Css NA 0.01468 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046785 Css NA 0.1283 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046785 Css NA 0.01774 mg/L PBTK NA 50% Rat Human -DTXSID4046785 Css NA 0.1068 mg/L PBTK NA 95% Rat Human -DTXSID4046787 Clint NA 3.321 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046787 Fup NA 0.0082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046787 Vd NA 0.7325 L/kg 1compartment NA NA Human Human -DTXSID4046787 Days.Css NA 14 Days PBTK NA NA Human Human -DTXSID4046787 TK.Half.Life NA 75.3 hours 1compartment NA NA Human Human -DTXSID4046787 Css NA 18.49 mg/L 3compartmentss NA 50% Human Human -DTXSID4046787 Css NA 148.9 mg/L 3compartmentss NA 95% Human Human -DTXSID4046787 Css NA 11.07 mg/L PBTK NA 50% Human Human -DTXSID4046787 Css NA 86.49 mg/L PBTK NA 95% Human Human -DTXSID4046787 Clint NA 3.321 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046787 Fup NA 0.0082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046787 Vd NA 0.5441 L/kg 1compartment NA NA Rat Human -DTXSID4046787 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID4046787 TK.Half.Life NA 32.48 hours 1compartment NA NA Rat Human -DTXSID4046787 Css NA 9.695 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046787 Css NA 59.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046787 Css NA 5.408 mg/L PBTK NA 50% Rat Human -DTXSID4046787 Css NA 32.27 mg/L PBTK NA 95% Rat Human -DTXSID4046810 Clint NA 5.667 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046810 Fup NA 0.0916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046810 Vd NA 0.6631 L/kg 1compartment NA NA Human Human +DTXSID4046785 TK.Half.Life NA 1.669 hours 1compartment NA NA Rat Human +DTXSID4046785 Css NA 0.01269 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046785 Css NA 0.08367 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046785 Css NA 0.01186 mg/L PBTK NA 50% Rat Human +DTXSID4046785 Css NA 0.05778 mg/L PBTK NA 95% Rat Human +DTXSID4046787 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046787 Fup 0.0413 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046787 Vd NA 1.574 L/kg 1compartment NA NA Human Human +DTXSID4046787 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046787 TK.Half.Life NA 8.652 hours 1compartment NA NA Human Human +DTXSID4046787 Css NA 0.7854 mg/L 3compartmentss NA 50% Human Human +DTXSID4046787 Css NA 6.625 mg/L 3compartmentss NA 95% Human Human +DTXSID4046787 Css NA 0.5001 mg/L PBTK NA 50% Human Human +DTXSID4046787 Css NA 4.007 mg/L PBTK NA 95% Human Human +DTXSID4046787 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046787 Fup 0.0413 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046787 Vd NA 1.178 L/kg 1compartment NA NA Rat Human +DTXSID4046787 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046787 TK.Half.Life NA 3.26 hours 1compartment NA NA Rat Human +DTXSID4046787 Css NA 0.1012 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046787 Css NA 0.6803 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046787 Css NA 0.06272 mg/L PBTK NA 50% Rat Human +DTXSID4046787 Css NA 0.4057 mg/L PBTK NA 95% Rat Human +DTXSID4046810 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046810 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046810 Vd NA 0.8736 L/kg 1compartment NA NA Human Human DTXSID4046810 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046810 TK.Half.Life NA 4.969 hours 1compartment NA NA Human Human -DTXSID4046810 Css NA 1.127 mg/L 3compartmentss NA 50% Human Human -DTXSID4046810 Css NA 7.449 mg/L 3compartmentss NA 95% Human Human -DTXSID4046810 Css NA 0.7074 mg/L PBTK NA 50% Human Human -DTXSID4046810 Css NA 4.51 mg/L PBTK NA 95% Human Human -DTXSID4046810 Clint NA 5.667 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046810 Fup NA 0.0916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046810 Vd NA 0.5454 L/kg 1compartment NA NA Rat Human +DTXSID4046810 TK.Half.Life NA 3.667 hours 1compartment NA NA Human Human +DTXSID4046810 Css NA 0.4666 mg/L 3compartmentss NA 50% Human Human +DTXSID4046810 Css NA 2.773 mg/L 3compartmentss NA 95% Human Human +DTXSID4046810 Css NA 0.3167 mg/L PBTK NA 50% Human Human +DTXSID4046810 Css NA 1.763 mg/L PBTK NA 95% Human Human +DTXSID4046810 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046810 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046810 Vd NA 0.7241 L/kg 1compartment NA NA Rat Human DTXSID4046810 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046810 TK.Half.Life NA 2.419 hours 1compartment NA NA Rat Human -DTXSID4046810 Css NA 0.59 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046810 Css NA 2.943 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046810 Css NA 0.351 mg/L PBTK NA 50% Rat Human -DTXSID4046810 Css NA 1.659 mg/L PBTK NA 95% Rat Human -DTXSID4046812 Clint NA 9.382 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046812 Fup NA 0.0144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046812 Vd NA 3.073 L/kg 1compartment NA NA Human Human -DTXSID4046812 Days.Css NA 35 Days PBTK NA NA Human Human -DTXSID4046812 TK.Half.Life NA 181.3 hours 1compartment NA NA Human Human -DTXSID4046812 Css NA 7.512 mg/L 3compartmentss NA 50% Human Human -DTXSID4046812 Css NA 45.32 mg/L 3compartmentss NA 95% Human Human -DTXSID4046812 Css NA 5.18 mg/L PBTK NA 50% Human Human -DTXSID4046812 Css NA 30.04 mg/L PBTK NA 95% Human Human -DTXSID4046812 Clint NA 9.382 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046812 Fup NA 0.0144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046812 Vd NA 2.302 L/kg 1compartment NA NA Rat Human -DTXSID4046812 Days.Css NA 20 Days PBTK NA NA Rat Human -DTXSID4046812 TK.Half.Life NA 25.41 hours 1compartment NA NA Rat Human -DTXSID4046812 Css NA 4.184 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046812 Css NA 21.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046812 Css NA 2.764 mg/L PBTK NA 50% Rat Human -DTXSID4046812 Css NA 13.47 mg/L PBTK NA 95% Rat Human -DTXSID4046814 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046814 Fup NA 0.5466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046814 Vd NA 0.614 L/kg 1compartment NA NA Human Human +DTXSID4046810 TK.Half.Life NA 1.726 hours 1compartment NA NA Rat Human +DTXSID4046810 Css NA 0.05594 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046810 Css NA 0.2462 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046810 Css NA 0.03738 mg/L PBTK NA 50% Rat Human +DTXSID4046810 Css NA 0.1521 mg/L PBTK NA 95% Rat Human +DTXSID4046812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046812 Fup 0.016 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046812 Vd NA 3.08 L/kg 1compartment NA NA Human Human +DTXSID4046812 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID4046812 TK.Half.Life NA 79.93 hours 1compartment NA NA Human Human +DTXSID4046812 Css NA 3.147 mg/L 3compartmentss NA 50% Human Human +DTXSID4046812 Css NA 20.27 mg/L 3compartmentss NA 95% Human Human +DTXSID4046812 Css NA 2.161 mg/L PBTK NA 50% Human Human +DTXSID4046812 Css NA 13.72 mg/L PBTK NA 95% Human Human +DTXSID4046812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046812 Fup 0.016 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046812 Vd NA 2.307 L/kg 1compartment NA NA Rat Human +DTXSID4046812 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID4046812 TK.Half.Life NA 11.4 hours 1compartment NA NA Rat Human +DTXSID4046812 Css NA 0.4062 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046812 Css NA 2.257 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046812 Css NA 0.2776 mg/L PBTK NA 50% Rat Human +DTXSID4046812 Css NA 1.517 mg/L PBTK NA 95% Rat Human +DTXSID4046814 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046814 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046814 Vd NA 0.3756 L/kg 1compartment NA NA Human Human DTXSID4046814 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046814 TK.Half.Life NA 7.285 hours 1compartment NA NA Human Human -DTXSID4046814 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human -DTXSID4046814 Css NA 8.313 mg/L 3compartmentss NA 95% Human Human -DTXSID4046814 Css NA 1.06 mg/L PBTK NA 50% Human Human -DTXSID4046814 Css NA 5.217 mg/L PBTK NA 95% Human Human -DTXSID4046814 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046814 Fup NA 0.5466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046814 Vd NA 0.6261 L/kg 1compartment NA NA Rat Human +DTXSID4046814 TK.Half.Life NA 9.002 hours 1compartment NA NA Human Human +DTXSID4046814 Css NA 1.565 mg/L 3compartmentss NA 50% Human Human +DTXSID4046814 Css NA 6.333 mg/L 3compartmentss NA 95% Human Human +DTXSID4046814 Css NA 1.053 mg/L PBTK NA 50% Human Human +DTXSID4046814 Css NA 3.899 mg/L PBTK NA 95% Human Human +DTXSID4046814 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046814 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046814 Vd NA 0.3895 L/kg 1compartment NA NA Rat Human DTXSID4046814 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046814 TK.Half.Life NA 2.528 hours 1compartment NA NA Rat Human -DTXSID4046814 Css NA 0.3622 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046814 Css NA 2.046 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046814 Css NA 0.2678 mg/L PBTK NA 50% Rat Human -DTXSID4046814 Css NA 1.196 mg/L PBTK NA 95% Rat Human +DTXSID4046814 TK.Half.Life NA 3.181 hours 1compartment NA NA Rat Human +DTXSID4046814 Css NA 0.00847 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046814 Css NA 0.03596 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046814 Css NA 0.005415 mg/L PBTK NA 50% Rat Human +DTXSID4046814 Css NA 0.02107 mg/L PBTK NA 95% Rat Human DTXSID4046816 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4046816 Fup NA 0.1416 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046816 Vd NA 35.25 L/kg 1compartment NA NA Human Human -DTXSID4046816 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4046816 TK.Half.Life NA 1643000 hours 1compartment NA NA Human Human -DTXSID4046816 Css NA 950.2 mg/L 3compartmentss NA 50% Human Human -DTXSID4046816 Css NA 2444 mg/L 3compartmentss NA 95% Human Human -DTXSID4046816 Css NA 3603 mg/L PBTK NA 50% Human Human -DTXSID4046816 Css NA 7671 mg/L PBTK NA 95% Human Human +DTXSID4046816 Vd NA 8.587 L/kg 1compartment NA NA Human Human +DTXSID4046816 Days.Css NA 1610 Days PBTK NA NA Human Human +DTXSID4046816 TK.Half.Life NA 5945 hours 1compartment NA NA Human Human +DTXSID4046816 Css NA 39.22 mg/L 3compartmentss NA 50% Human Human +DTXSID4046816 Css NA 132.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4046816 Css NA 48.48 mg/L PBTK NA 50% Human Human +DTXSID4046816 Css NA 129.2 mg/L PBTK NA 95% Human Human DTXSID4046816 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4046816 Fup NA 0.1416 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046816 Vd NA 29.31 L/kg 1compartment NA NA Rat Human -DTXSID4046816 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID4046816 TK.Half.Life NA 111300 hours 1compartment NA NA Rat Human -DTXSID4046816 Css NA 231.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046816 Css NA 427.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046816 Css NA 952.1 mg/L PBTK NA 50% Rat Human -DTXSID4046816 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID4046818 Clint NA 17.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046818 Fup NA 0.1572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046818 Vd NA 1.981 L/kg 1compartment NA NA Human Human +DTXSID4046816 Vd NA 6.992 L/kg 1compartment NA NA Rat Human +DTXSID4046816 Days.Css NA 446 Days PBTK NA NA Rat Human +DTXSID4046816 TK.Half.Life NA 476.1 hours 1compartment NA NA Rat Human +DTXSID4046816 Css NA 0.8938 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046816 Css NA 4.315 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046816 Css NA 1.106 mg/L PBTK NA 50% Rat Human +DTXSID4046816 Css NA 4.426 mg/L PBTK NA 95% Rat Human +DTXSID4046818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046818 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046818 Vd NA 2.003 L/kg 1compartment NA NA Human Human DTXSID4046818 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046818 TK.Half.Life NA 5.532 hours 1compartment NA NA Human Human -DTXSID4046818 Css NA 0.2782 mg/L 3compartmentss NA 50% Human Human -DTXSID4046818 Css NA 1.851 mg/L 3compartmentss NA 95% Human Human -DTXSID4046818 Css NA 0.1945 mg/L PBTK NA 50% Human Human -DTXSID4046818 Css NA 1.223 mg/L PBTK NA 95% Human Human -DTXSID4046818 Clint NA 17.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046818 Fup NA 0.1572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046818 Vd NA 1.522 L/kg 1compartment NA NA Rat Human +DTXSID4046818 TK.Half.Life NA 5.115 hours 1compartment NA NA Human Human +DTXSID4046818 Css NA 0.2402 mg/L 3compartmentss NA 50% Human Human +DTXSID4046818 Css NA 1.765 mg/L 3compartmentss NA 95% Human Human +DTXSID4046818 Css NA 0.1667 mg/L PBTK NA 50% Human Human +DTXSID4046818 Css NA 1.152 mg/L PBTK NA 95% Human Human +DTXSID4046818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046818 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046818 Vd NA 1.533 L/kg 1compartment NA NA Rat Human DTXSID4046818 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046818 TK.Half.Life NA 1.887 hours 1compartment NA NA Rat Human -DTXSID4046818 Css NA 0.1503 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046818 Css NA 0.7862 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046818 Css NA 0.1013 mg/L PBTK NA 50% Rat Human -DTXSID4046818 Css NA 0.4922 mg/L PBTK NA 95% Rat Human -DTXSID4046862 Clint NA 101.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4046818 TK.Half.Life NA 1.729 hours 1compartment NA NA Rat Human +DTXSID4046818 Css NA 0.03102 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046818 Css NA 0.172 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046818 Css NA 0.0213 mg/L PBTK NA 50% Rat Human +DTXSID4046818 Css NA 0.1108 mg/L PBTK NA 95% Rat Human +DTXSID4046862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4046862 Fup 0.22 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4046862 Vd NA 2.994 L/kg 1compartment NA NA Human Human +DTXSID4046862 Vd NA 2.705 L/kg 1compartment NA NA Human Human DTXSID4046862 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046862 TK.Half.Life NA 5.488 hours 1compartment NA NA Human Human -DTXSID4046862 Css NA 0.1267 mg/L 3compartmentss NA 50% Human Human -DTXSID4046862 Css NA 0.7889 mg/L 3compartmentss NA 95% Human Human -DTXSID4046862 Css NA 0.09067 mg/L PBTK NA 50% Human Human -DTXSID4046862 Css NA 0.5516 mg/L PBTK NA 95% Human Human -DTXSID4046862 Clint NA 101.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4046862 TK.Half.Life NA 8.318 hours 1compartment NA NA Human Human +DTXSID4046862 Css NA 0.2716 mg/L 3compartmentss NA 50% Human Human +DTXSID4046862 Css NA 1.739 mg/L 3compartmentss NA 95% Human Human +DTXSID4046862 Css NA 0.197 mg/L PBTK NA 50% Human Human +DTXSID4046862 Css NA 1.207 mg/L PBTK NA 95% Human Human +DTXSID4046862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4046862 Fup 0.22 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4046862 Vd NA 2.257 L/kg 1compartment NA NA Rat Human +DTXSID4046862 Vd NA 2.055 L/kg 1compartment NA NA Rat Human DTXSID4046862 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046862 TK.Half.Life NA 1.277 hours 1compartment NA NA Rat Human -DTXSID4046862 Css NA 0.0706 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046862 Css NA 0.3755 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046862 Css NA 0.04832 mg/L PBTK NA 50% Rat Human -DTXSID4046862 Css NA 0.2507 mg/L PBTK NA 95% Rat Human +DTXSID4046862 TK.Half.Life NA 2.039 hours 1compartment NA NA Rat Human +DTXSID4046862 Css NA 0.03448 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046862 Css NA 0.1788 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046862 Css NA 0.02484 mg/L PBTK NA 50% Rat Human +DTXSID4046862 Css NA 0.1261 mg/L PBTK NA 95% Rat Human DTXSID4046864 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4046864 Fup NA 0.5047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046864 Vd NA 0.8017 L/kg 1compartment NA NA Human Human -DTXSID4046864 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4046864 TK.Half.Life NA 10.28 hours 1compartment NA NA Human Human -DTXSID4046864 Css NA 1.39 mg/L 3compartmentss NA 50% Human Human -DTXSID4046864 Css NA 7.424 mg/L 3compartmentss NA 95% Human Human -DTXSID4046864 Css NA 1.107 mg/L PBTK NA 50% Human Human -DTXSID4046864 Css NA 4.836 mg/L PBTK NA 95% Human Human +DTXSID4046864 Vd NA 0.3515 L/kg 1compartment NA NA Human Human +DTXSID4046864 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046864 TK.Half.Life NA 4.507 hours 1compartment NA NA Human Human +DTXSID4046864 Css NA 1.356 mg/L 3compartmentss NA 50% Human Human +DTXSID4046864 Css NA 6.711 mg/L 3compartmentss NA 95% Human Human +DTXSID4046864 Css NA 0.9336 mg/L PBTK NA 50% Human Human +DTXSID4046864 Css NA 4.098 mg/L PBTK NA 95% Human Human DTXSID4046864 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4046864 Fup NA 0.5047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046864 Vd NA 0.8144 L/kg 1compartment NA NA Rat Human +DTXSID4046864 Vd NA 0.3705 L/kg 1compartment NA NA Rat Human DTXSID4046864 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046864 TK.Half.Life NA 3.556 hours 1compartment NA NA Rat Human -DTXSID4046864 Css NA 0.3696 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046864 Css NA 1.836 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046864 Css NA 0.2842 mg/L PBTK NA 50% Rat Human -DTXSID4046864 Css NA 1.1 mg/L PBTK NA 95% Rat Human -DTXSID4046866 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046866 Fup NA 0.2843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046866 Vd NA 0.5092 L/kg 1compartment NA NA Human Human +DTXSID4046864 TK.Half.Life NA 1.618 hours 1compartment NA NA Rat Human +DTXSID4046864 Css NA 0.02538 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046864 Css NA 0.1747 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046864 Css NA 0.0167 mg/L PBTK NA 50% Rat Human +DTXSID4046864 Css NA 0.1055 mg/L PBTK NA 95% Rat Human +DTXSID4046866 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046866 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046866 Vd NA 0.5121 L/kg 1compartment NA NA Human Human DTXSID4046866 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4046866 TK.Half.Life NA 11.63 hours 1compartment NA NA Human Human -DTXSID4046866 Css NA 2.706 mg/L 3compartmentss NA 50% Human Human -DTXSID4046866 Css NA 10.31 mg/L 3compartmentss NA 95% Human Human -DTXSID4046866 Css NA 1.877 mg/L PBTK NA 50% Human Human -DTXSID4046866 Css NA 6.468 mg/L PBTK NA 95% Human Human -DTXSID4046866 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046866 Fup NA 0.2843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046866 Vd NA 0.5065 L/kg 1compartment NA NA Rat Human +DTXSID4046866 TK.Half.Life NA 11.11 hours 1compartment NA NA Human Human +DTXSID4046866 Css NA 2.143 mg/L 3compartmentss NA 50% Human Human +DTXSID4046866 Css NA 8.582 mg/L 3compartmentss NA 95% Human Human +DTXSID4046866 Css NA 1.51 mg/L PBTK NA 50% Human Human +DTXSID4046866 Css NA 5.365 mg/L PBTK NA 95% Human Human +DTXSID4046866 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046866 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046866 Vd NA 0.5116 L/kg 1compartment NA NA Rat Human DTXSID4046866 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046866 TK.Half.Life NA 3.932 hours 1compartment NA NA Rat Human -DTXSID4046866 Css NA 0.7425 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046866 Css NA 2.453 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046866 Css NA 0.4911 mg/L PBTK NA 50% Rat Human -DTXSID4046866 Css NA 1.427 mg/L PBTK NA 95% Rat Human -DTXSID4046868 Clint NA 91.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046868 Fup NA 0.2304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046868 Vd NA 0.3397 L/kg 1compartment NA NA Human Human +DTXSID4046866 TK.Half.Life NA 3.775 hours 1compartment NA NA Rat Human +DTXSID4046866 Css NA 0.03895 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046866 Css NA 0.2351 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046866 Css NA 0.0262 mg/L PBTK NA 50% Rat Human +DTXSID4046866 Css NA 0.147 mg/L PBTK NA 95% Rat Human +DTXSID4046868 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046868 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046868 Vd NA 0.4054 L/kg 1compartment NA NA Human Human DTXSID4046868 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046868 TK.Half.Life NA 0.3462 hours 1compartment NA NA Human Human -DTXSID4046868 Css NA 0.02477 mg/L 3compartmentss NA 50% Human Human -DTXSID4046868 Css NA 0.1817 mg/L 3compartmentss NA 95% Human Human -DTXSID4046868 Css NA 0.01608 mg/L PBTK NA 50% Human Human -DTXSID4046868 Css NA 0.1161 mg/L PBTK NA 95% Human Human -DTXSID4046868 Clint NA 91.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046868 Fup NA 0.2304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046868 Vd NA 0.3528 L/kg 1compartment NA NA Rat Human +DTXSID4046868 TK.Half.Life NA 7.998 hours 1compartment NA NA Human Human +DTXSID4046868 Css NA 2.28 mg/L 3compartmentss NA 50% Human Human +DTXSID4046868 Css NA 9.052 mg/L 3compartmentss NA 95% Human Human +DTXSID4046868 Css NA 1.575 mg/L PBTK NA 50% Human Human +DTXSID4046868 Css NA 5.659 mg/L PBTK NA 95% Human Human +DTXSID4046868 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046868 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046868 Vd NA 0.4221 L/kg 1compartment NA NA Rat Human DTXSID4046868 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046868 TK.Half.Life NA 0.1717 hours 1compartment NA NA Rat Human -DTXSID4046868 Css NA 0.01382 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046868 Css NA 0.08077 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046868 Css NA 0.00852 mg/L PBTK NA 50% Rat Human -DTXSID4046868 Css NA 0.04838 mg/L PBTK NA 95% Rat Human -DTXSID4046949 Clint NA 9.337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046949 Fup NA 0.09 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046949 Vd NA 3.104 L/kg 1compartment NA NA Human Human -DTXSID4046949 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID4046949 TK.Half.Life NA 125.8 hours 1compartment NA NA Human Human -DTXSID4046949 Css NA 4.898 mg/L 3compartmentss NA 50% Human Human -DTXSID4046949 Css NA 30.7 mg/L 3compartmentss NA 95% Human Human -DTXSID4046949 Css NA 3.402 mg/L PBTK NA 50% Human Human -DTXSID4046949 Css NA 20.72 mg/L PBTK NA 95% Human Human -DTXSID4046949 Clint NA 9.337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046949 Fup NA 0.09 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046949 Vd NA 2.328 L/kg 1compartment NA NA Rat Human -DTXSID4046949 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID4046949 TK.Half.Life NA 17.07 hours 1compartment NA NA Rat Human -DTXSID4046949 Css NA 2.732 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046949 Css NA 13.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046949 Css NA 1.826 mg/L PBTK NA 50% Rat Human -DTXSID4046949 Css NA 8.826 mg/L PBTK NA 95% Rat Human -DTXSID4046991 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046991 Fup NA 0.5008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046991 Vd NA 0.4188 L/kg 1compartment NA NA Human Human +DTXSID4046868 TK.Half.Life NA 2.837 hours 1compartment NA NA Rat Human +DTXSID4046868 Css NA 0.1459 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046868 Css NA 0.4903 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046868 Css NA 0.09872 mg/L PBTK NA 50% Rat Human +DTXSID4046868 Css NA 0.2936 mg/L PBTK NA 95% Rat Human +DTXSID4046943 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046943 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046943 Vd NA 2.248 L/kg 1compartment NA NA Human Human +DTXSID4046943 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046943 TK.Half.Life NA 3.339 hours 1compartment NA NA Human Human +DTXSID4046943 Css NA 0.08903 mg/L 3compartmentss NA 50% Human Human +DTXSID4046943 Css NA 0.6149 mg/L 3compartmentss NA 95% Human Human +DTXSID4046943 Css NA 0.06851 mg/L PBTK NA 50% Human Human +DTXSID4046943 Css NA 0.4444 mg/L PBTK NA 95% Human Human +DTXSID4046943 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046943 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046943 Vd NA 1.748 L/kg 1compartment NA NA Rat Human +DTXSID4046943 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046943 TK.Half.Life NA 1.071 hours 1compartment NA NA Rat Human +DTXSID4046943 Css NA 0.01104 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046943 Css NA 0.05857 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046943 Css NA 0.008582 mg/L PBTK NA 50% Rat Human +DTXSID4046943 Css NA 0.04149 mg/L PBTK NA 95% Rat Human +DTXSID4046947 Clint 0.83 NA uL/min/million hepatocytes NA Yamagata 2017 NA Human Human +DTXSID4046947 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4046947 Vd NA 0.9268 L/kg 1compartment NA NA Human Human +DTXSID4046947 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4046947 TK.Half.Life NA 10.27 hours 1compartment NA NA Human Human +DTXSID4046947 Css NA 0.4734 mg/L 3compartmentss NA 50% Human Human +DTXSID4046947 Css NA 2.028 mg/L 3compartmentss NA 95% Human Human +DTXSID4046947 Css NA 0.4728 mg/L PBTK NA 50% Human Human +DTXSID4046947 Css NA 2.025 mg/L PBTK NA 95% Human Human +DTXSID4046947 Clint 0.83 NA uL/min/million hepatocytes NA Yamagata 2017 NA Rat Human +DTXSID4046947 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4046947 Vd NA 0.9295 L/kg 1compartment NA NA Rat Human +DTXSID4046947 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046947 TK.Half.Life NA 4.951 hours 1compartment NA NA Rat Human +DTXSID4046947 Css NA 0.003452 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046947 Css NA 0.01353 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046947 Css NA 0.003461 mg/L PBTK NA 50% Rat Human +DTXSID4046947 Css NA 0.01358 mg/L PBTK NA 95% Rat Human +DTXSID4046949 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046949 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046949 Vd NA 3.036 L/kg 1compartment NA NA Human Human +DTXSID4046949 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4046949 TK.Half.Life NA 12.42 hours 1compartment NA NA Human Human +DTXSID4046949 Css NA 0.3782 mg/L 3compartmentss NA 50% Human Human +DTXSID4046949 Css NA 2.428 mg/L 3compartmentss NA 95% Human Human +DTXSID4046949 Css NA 0.2811 mg/L PBTK NA 50% Human Human +DTXSID4046949 Css NA 1.717 mg/L PBTK NA 95% Human Human +DTXSID4046949 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046949 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046949 Vd NA 2.352 L/kg 1compartment NA NA Rat Human +DTXSID4046949 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4046949 TK.Half.Life NA 2.676 hours 1compartment NA NA Rat Human +DTXSID4046949 Css NA 0.04805 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046949 Css NA 0.246 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046949 Css NA 0.03574 mg/L PBTK NA 50% Rat Human +DTXSID4046949 Css NA 0.177 mg/L PBTK NA 95% Rat Human +DTXSID4046991 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046991 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046991 Vd NA 0.3616 L/kg 1compartment NA NA Human Human DTXSID4046991 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046991 TK.Half.Life NA 5.415 hours 1compartment NA NA Human Human -DTXSID4046991 Css NA 1.578 mg/L 3compartmentss NA 50% Human Human -DTXSID4046991 Css NA 7.897 mg/L 3compartmentss NA 95% Human Human -DTXSID4046991 Css NA 1.118 mg/L PBTK NA 50% Human Human -DTXSID4046991 Css NA 4.837 mg/L PBTK NA 95% Human Human -DTXSID4046991 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046991 Fup NA 0.5008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046991 Vd NA 0.4268 L/kg 1compartment NA NA Rat Human +DTXSID4046991 TK.Half.Life NA 6.161 hours 1compartment NA NA Human Human +DTXSID4046991 Css NA 1.108 mg/L 3compartmentss NA 50% Human Human +DTXSID4046991 Css NA 4.832 mg/L 3compartmentss NA 95% Human Human +DTXSID4046991 Css NA 0.7535 mg/L PBTK NA 50% Human Human +DTXSID4046991 Css NA 3.02 mg/L PBTK NA 95% Human Human +DTXSID4046991 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046991 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046991 Vd NA 0.3682 L/kg 1compartment NA NA Rat Human DTXSID4046991 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046991 TK.Half.Life NA 1.879 hours 1compartment NA NA Rat Human -DTXSID4046991 Css NA 0.4251 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046991 Css NA 1.825 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046991 Css NA 0.287 mg/L PBTK NA 50% Rat Human -DTXSID4046991 Css NA 1.053 mg/L PBTK NA 95% Rat Human -DTXSID4046999 Clint NA 0.6141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046999 Fup NA 0.1464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4046999 Vd NA 0.298 L/kg 1compartment NA NA Human Human +DTXSID4046991 TK.Half.Life NA 2.135 hours 1compartment NA NA Rat Human +DTXSID4046991 Css NA 0.00601 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046991 Css NA 0.02688 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046991 Css NA 0.003888 mg/L PBTK NA 50% Rat Human +DTXSID4046991 Css NA 0.01589 mg/L PBTK NA 95% Rat Human +DTXSID4046999 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046999 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4046999 Vd NA 0.4669 L/kg 1compartment NA NA Human Human DTXSID4046999 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4046999 TK.Half.Life NA 6.508 hours 1compartment NA NA Human Human -DTXSID4046999 Css NA 3.117 mg/L 3compartmentss NA 50% Human Human -DTXSID4046999 Css NA 15.18 mg/L 3compartmentss NA 95% Human Human -DTXSID4046999 Css NA 1.976 mg/L PBTK NA 50% Human Human -DTXSID4046999 Css NA 9.144 mg/L PBTK NA 95% Human Human -DTXSID4046999 Clint NA 0.6141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046999 Fup NA 0.1464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4046999 Vd NA 0.3001 L/kg 1compartment NA NA Rat Human +DTXSID4046999 TK.Half.Life NA 7.825 hours 1compartment NA NA Human Human +DTXSID4046999 Css NA 1.864 mg/L 3compartmentss NA 50% Human Human +DTXSID4046999 Css NA 7.978 mg/L 3compartmentss NA 95% Human Human +DTXSID4046999 Css NA 1.349 mg/L PBTK NA 50% Human Human +DTXSID4046999 Css NA 5.033 mg/L PBTK NA 95% Human Human +DTXSID4046999 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046999 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4046999 Vd NA 0.4743 L/kg 1compartment NA NA Rat Human DTXSID4046999 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4046999 TK.Half.Life NA 3.011 hours 1compartment NA NA Rat Human -DTXSID4046999 Css NA 1.212 mg/L 3compartmentss NA 50% Rat Human -DTXSID4046999 Css NA 4.882 mg/L 3compartmentss NA 95% Rat Human -DTXSID4046999 Css NA 0.7168 mg/L PBTK NA 50% Rat Human -DTXSID4046999 Css NA 2.71 mg/L PBTK NA 95% Rat Human -DTXSID4047040 Clint NA 0.5553 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047040 Fup NA 0.1003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047040 Vd NA 0.4972 L/kg 1compartment NA NA Human Human -DTXSID4047040 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4047040 TK.Half.Life NA 16.84 hours 1compartment NA NA Human Human -DTXSID4047040 Css NA 4.908 mg/L 3compartmentss NA 50% Human Human -DTXSID4047040 Css NA 26.06 mg/L 3compartmentss NA 95% Human Human -DTXSID4047040 Css NA 3.218 mg/L PBTK NA 50% Human Human -DTXSID4047040 Css NA 15.42 mg/L PBTK NA 95% Human Human -DTXSID4047040 Clint NA 0.5553 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047040 Fup NA 0.1003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047040 Vd NA 0.4466 L/kg 1compartment NA NA Rat Human -DTXSID4047040 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047040 TK.Half.Life NA 6.769 hours 1compartment NA NA Rat Human -DTXSID4047040 Css NA 1.888 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047040 Css NA 8.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047040 Css NA 1.158 mg/L PBTK NA 50% Rat Human -DTXSID4047040 Css NA 4.527 mg/L PBTK NA 95% Rat Human -DTXSID4047044 Clint NA 2.696 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047044 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047044 Vd NA 3.118 L/kg 1compartment NA NA Human Human -DTXSID4047044 Days.Css NA 165 Days PBTK NA NA Human Human -DTXSID4047044 TK.Half.Life NA 680.9 hours 1compartment NA NA Human Human -DTXSID4047044 Css NA 26.78 mg/L 3compartmentss NA 50% Human Human -DTXSID4047044 Css NA 164.4 mg/L 3compartmentss NA 95% Human Human -DTXSID4047044 Css NA 18.56 mg/L PBTK NA 50% Human Human -DTXSID4047044 Css NA 110.2 mg/L PBTK NA 95% Human Human -DTXSID4047044 Clint NA 2.696 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047044 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047044 Vd NA 2.337 L/kg 1compartment NA NA Rat Human -DTXSID4047044 Days.Css NA 89 Days PBTK NA NA Rat Human -DTXSID4047044 TK.Half.Life NA 87.8 hours 1compartment NA NA Rat Human -DTXSID4047044 Css NA 15.17 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047044 Css NA 68.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047044 Css NA 10.02 mg/L PBTK NA 50% Rat Human -DTXSID4047044 Css NA 43.7 mg/L PBTK NA 95% Rat Human -DTXSID4047090 Clint NA 1.528 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047090 Fup NA 0.3501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047090 Vd NA 1.523 L/kg 1compartment NA NA Human Human +DTXSID4046999 TK.Half.Life NA 2.708 hours 1compartment NA NA Rat Human +DTXSID4046999 Css NA 0.1184 mg/L 3compartmentss NA 50% Rat Human +DTXSID4046999 Css NA 0.4267 mg/L 3compartmentss NA 95% Rat Human +DTXSID4046999 Css NA 0.08474 mg/L PBTK NA 50% Rat Human +DTXSID4046999 Css NA 0.2603 mg/L PBTK NA 95% Rat Human +DTXSID4047042 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047042 Fup 0.0177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047042 Vd NA 2.851 L/kg 1compartment NA NA Human Human +DTXSID4047042 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4047042 TK.Half.Life NA 49.06 hours 1compartment NA NA Human Human +DTXSID4047042 Css NA 2.25 mg/L 3compartmentss NA 50% Human Human +DTXSID4047042 Css NA 15.27 mg/L 3compartmentss NA 95% Human Human +DTXSID4047042 Css NA 1.522 mg/L PBTK NA 50% Human Human +DTXSID4047042 Css NA 9.874 mg/L PBTK NA 95% Human Human +DTXSID4047042 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047042 Fup 0.0177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047042 Vd NA 2.132 L/kg 1compartment NA NA Rat Human +DTXSID4047042 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4047042 TK.Half.Life NA 9.15 hours 1compartment NA NA Rat Human +DTXSID4047042 Css NA 0.2895 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047042 Css NA 1.718 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047042 Css NA 0.1938 mg/L PBTK NA 50% Rat Human +DTXSID4047042 Css NA 1.09 mg/L PBTK NA 95% Rat Human +DTXSID4047090 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047090 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047090 Vd NA 1.374 L/kg 1compartment NA NA Human Human DTXSID4047090 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047090 TK.Half.Life NA 10.24 hours 1compartment NA NA Human Human -DTXSID4047090 Css NA 0.6929 mg/L 3compartmentss NA 50% Human Human -DTXSID4047090 Css NA 3.202 mg/L 3compartmentss NA 95% Human Human -DTXSID4047090 Css NA 0.54 mg/L PBTK NA 50% Human Human -DTXSID4047090 Css NA 2.17 mg/L PBTK NA 95% Human Human -DTXSID4047090 Clint NA 1.528 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047090 Fup NA 0.3501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047090 Vd NA 1.244 L/kg 1compartment NA NA Rat Human +DTXSID4047090 TK.Half.Life NA 3.997 hours 1compartment NA NA Human Human +DTXSID4047090 Css NA 0.2623 mg/L 3compartmentss NA 50% Human Human +DTXSID4047090 Css NA 1.548 mg/L 3compartmentss NA 95% Human Human +DTXSID4047090 Css NA 0.1955 mg/L PBTK NA 50% Human Human +DTXSID4047090 Css NA 1.067 mg/L PBTK NA 95% Human Human +DTXSID4047090 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047090 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047090 Vd NA 1.12 L/kg 1compartment NA NA Rat Human DTXSID4047090 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047090 TK.Half.Life NA 3.721 hours 1compartment NA NA Rat Human -DTXSID4047090 Css NA 0.299 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047090 Css NA 1.094 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047090 Css NA 0.2254 mg/L PBTK NA 50% Rat Human -DTXSID4047090 Css NA 0.6916 mg/L PBTK NA 95% Rat Human -DTXSID4047094 Clint NA 1.467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047094 Fup NA 0.319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047094 Vd NA 1.269 L/kg 1compartment NA NA Human Human +DTXSID4047090 TK.Half.Life NA 1.678 hours 1compartment NA NA Rat Human +DTXSID4047090 Css NA 0.03066 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047090 Css NA 0.1345 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047090 Css NA 0.02282 mg/L PBTK NA 50% Rat Human +DTXSID4047090 Css NA 0.08989 mg/L PBTK NA 95% Rat Human +DTXSID4047092 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047092 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047092 Vd NA 1.81 L/kg 1compartment NA NA Human Human +DTXSID4047092 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047092 TK.Half.Life NA 4.359 hours 1compartment NA NA Human Human +DTXSID4047092 Css NA 0.2258 mg/L 3compartmentss NA 50% Human Human +DTXSID4047092 Css NA 1.61 mg/L 3compartmentss NA 95% Human Human +DTXSID4047092 Css NA 0.1563 mg/L PBTK NA 50% Human Human +DTXSID4047092 Css NA 1.052 mg/L PBTK NA 95% Human Human +DTXSID4047092 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047092 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047092 Vd NA 1.389 L/kg 1compartment NA NA Rat Human +DTXSID4047092 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047092 TK.Half.Life NA 1.559 hours 1compartment NA NA Rat Human +DTXSID4047092 Css NA 0.02938 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047092 Css NA 0.1656 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047092 Css NA 0.01991 mg/L PBTK NA 50% Rat Human +DTXSID4047092 Css NA 0.1061 mg/L PBTK NA 95% Rat Human +DTXSID4047094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047094 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047094 Vd NA 1.183 L/kg 1compartment NA NA Human Human DTXSID4047094 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047094 TK.Half.Life NA 8.902 hours 1compartment NA NA Human Human -DTXSID4047094 Css NA 0.7346 mg/L 3compartmentss NA 50% Human Human -DTXSID4047094 Css NA 3.402 mg/L 3compartmentss NA 95% Human Human -DTXSID4047094 Css NA 0.5606 mg/L PBTK NA 50% Human Human -DTXSID4047094 Css NA 2.272 mg/L PBTK NA 95% Human Human -DTXSID4047094 Clint NA 1.467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047094 Fup NA 0.319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047094 Vd NA 1.055 L/kg 1compartment NA NA Rat Human +DTXSID4047094 TK.Half.Life NA 1.638 hours 1compartment NA NA Human Human +DTXSID4047094 Css NA 0.0755 mg/L 3compartmentss NA 50% Human Human +DTXSID4047094 Css NA 0.5582 mg/L 3compartmentss NA 95% Human Human +DTXSID4047094 Css NA 0.05598 mg/L PBTK NA 50% Human Human +DTXSID4047094 Css NA 0.3769 mg/L PBTK NA 95% Human Human +DTXSID4047094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047094 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047094 Vd NA 0.9818 L/kg 1compartment NA NA Rat Human DTXSID4047094 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047094 TK.Half.Life NA 3.474 hours 1compartment NA NA Rat Human -DTXSID4047094 Css NA 0.3185 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047094 Css NA 1.168 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047094 Css NA 0.2335 mg/L PBTK NA 50% Rat Human -DTXSID4047094 Css NA 0.7213 mg/L PBTK NA 95% Rat Human +DTXSID4047094 TK.Half.Life NA 0.6957 hours 1compartment NA NA Rat Human +DTXSID4047094 Css NA 0.009624 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047094 Css NA 0.05353 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047094 Css NA 0.007122 mg/L PBTK NA 50% Rat Human +DTXSID4047094 Css NA 0.03636 mg/L PBTK NA 95% Rat Human DTXSID4047096 Clint NA 2.327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4047096 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047096 Vd NA 1.211 L/kg 1compartment NA NA Human Human +DTXSID4047096 Vd NA 1.492 L/kg 1compartment NA NA Human Human DTXSID4047096 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047096 TK.Half.Life NA 2.375 hours 1compartment NA NA Human Human -DTXSID4047096 Css NA 0.1906 mg/L 3compartmentss NA 50% Human Human -DTXSID4047096 Css NA 1.415 mg/L 3compartmentss NA 95% Human Human -DTXSID4047096 Css NA 0.1723 mg/L PBTK NA 50% Human Human -DTXSID4047096 Css NA 0.9814 mg/L PBTK NA 95% Human Human +DTXSID4047096 TK.Half.Life NA 2.915 hours 1compartment NA NA Human Human +DTXSID4047096 Css NA 0.1548 mg/L 3compartmentss NA 50% Human Human +DTXSID4047096 Css NA 1.286 mg/L 3compartmentss NA 95% Human Human +DTXSID4047096 Css NA 0.1445 mg/L PBTK NA 50% Human Human +DTXSID4047096 Css NA 0.9011 mg/L PBTK NA 95% Human Human DTXSID4047096 Clint NA 2.327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4047096 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047096 Vd NA 1.234 L/kg 1compartment NA NA Rat Human +DTXSID4047096 Vd NA 1.503 L/kg 1compartment NA NA Rat Human DTXSID4047096 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047096 TK.Half.Life NA 1.278 hours 1compartment NA NA Rat Human -DTXSID4047096 Css NA 0.08055 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047096 Css NA 0.5821 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047096 Css NA 0.07222 mg/L PBTK NA 50% Rat Human -DTXSID4047096 Css NA 0.3653 mg/L PBTK NA 95% Rat Human -DTXSID4047121 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047121 Fup NA 0.3253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047121 Vd NA 1.538 L/kg 1compartment NA NA Human Human +DTXSID4047096 TK.Half.Life NA 1.555 hours 1compartment NA NA Rat Human +DTXSID4047096 Css NA 0.004679 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047096 Css NA 0.04309 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047096 Css NA 0.004334 mg/L PBTK NA 50% Rat Human +DTXSID4047096 Css NA 0.03064 mg/L PBTK NA 95% Rat Human +DTXSID4047098 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047098 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047098 Vd NA 1.088 L/kg 1compartment NA NA Human Human +DTXSID4047098 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047098 TK.Half.Life NA 1.687 hours 1compartment NA NA Human Human +DTXSID4047098 Css NA 0.09476 mg/L 3compartmentss NA 50% Human Human +DTXSID4047098 Css NA 0.6678 mg/L 3compartmentss NA 95% Human Human +DTXSID4047098 Css NA 0.06782 mg/L PBTK NA 50% Human Human +DTXSID4047098 Css NA 0.4455 mg/L PBTK NA 95% Human Human +DTXSID4047098 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047098 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047098 Vd NA 0.8984 L/kg 1compartment NA NA Rat Human +DTXSID4047098 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047098 TK.Half.Life NA 0.7292 hours 1compartment NA NA Rat Human +DTXSID4047098 Css NA 0.0122 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047098 Css NA 0.06677 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047098 Css NA 0.008615 mg/L PBTK NA 50% Rat Human +DTXSID4047098 Css NA 0.04382 mg/L PBTK NA 95% Rat Human +DTXSID4047121 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047121 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047121 Vd NA 0.7988 L/kg 1compartment NA NA Human Human DTXSID4047121 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047121 TK.Half.Life NA 2.999 hours 1compartment NA NA Human Human -DTXSID4047121 Css NA 0.1524 mg/L 3compartmentss NA 50% Human Human -DTXSID4047121 Css NA 0.9766 mg/L 3compartmentss NA 95% Human Human -DTXSID4047121 Css NA 0.1158 mg/L PBTK NA 50% Human Human -DTXSID4047121 Css NA 0.679 mg/L PBTK NA 95% Human Human -DTXSID4047121 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047121 Fup NA 0.3253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047121 Vd NA 1.233 L/kg 1compartment NA NA Rat Human +DTXSID4047121 TK.Half.Life NA 1.833 hours 1compartment NA NA Human Human +DTXSID4047121 Css NA 0.2288 mg/L 3compartmentss NA 50% Human Human +DTXSID4047121 Css NA 1.817 mg/L 3compartmentss NA 95% Human Human +DTXSID4047121 Css NA 0.1473 mg/L PBTK NA 50% Human Human +DTXSID4047121 Css NA 1.104 mg/L PBTK NA 95% Human Human +DTXSID4047121 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047121 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047121 Vd NA 0.6454 L/kg 1compartment NA NA Rat Human DTXSID4047121 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047121 TK.Half.Life NA 1.185 hours 1compartment NA NA Rat Human -DTXSID4047121 Css NA 0.07922 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047121 Css NA 0.3821 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047121 Css NA 0.05814 mg/L PBTK NA 50% Rat Human -DTXSID4047121 Css NA 0.2482 mg/L PBTK NA 95% Rat Human -DTXSID4047173 Clint NA 1.965 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047173 Fup NA 0.5992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047173 Vd NA 0.5575 L/kg 1compartment NA NA Human Human +DTXSID4047121 TK.Half.Life NA 0.8327 hours 1compartment NA NA Rat Human +DTXSID4047121 Css NA 0.0294 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047121 Css NA 0.186 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047121 Css NA 0.01862 mg/L PBTK NA 50% Rat Human +DTXSID4047121 Css NA 0.1095 mg/L PBTK NA 95% Rat Human +DTXSID4047129 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047129 Fup 0.0927 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047129 Vd NA 2.913 L/kg 1compartment NA NA Human Human +DTXSID4047129 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4047129 TK.Half.Life NA 23.4 hours 1compartment NA NA Human Human +DTXSID4047129 Css NA 0.916 mg/L 3compartmentss NA 50% Human Human +DTXSID4047129 Css NA 5.593 mg/L 3compartmentss NA 95% Human Human +DTXSID4047129 Css NA 0.6374 mg/L PBTK NA 50% Human Human +DTXSID4047129 Css NA 3.783 mg/L PBTK NA 95% Human Human +DTXSID4047129 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047129 Fup 0.0927 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047129 Vd NA 2.188 L/kg 1compartment NA NA Rat Human +DTXSID4047129 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4047129 TK.Half.Life NA 4.368 hours 1compartment NA NA Rat Human +DTXSID4047129 Css NA 0.1185 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047129 Css NA 0.6274 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047129 Css NA 0.0815 mg/L PBTK NA 50% Rat Human +DTXSID4047129 Css NA 0.4134 mg/L PBTK NA 95% Rat Human +DTXSID4047173 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047173 Fup 0.888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047173 Vd NA 0.7038 L/kg 1compartment NA NA Human Human DTXSID4047173 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047173 TK.Half.Life NA 1.634 hours 1compartment NA NA Human Human -DTXSID4047173 Css NA 0.3098 mg/L 3compartmentss NA 50% Human Human -DTXSID4047173 Css NA 2.315 mg/L 3compartmentss NA 95% Human Human -DTXSID4047173 Css NA 0.2364 mg/L PBTK NA 50% Human Human -DTXSID4047173 Css NA 1.481 mg/L PBTK NA 95% Human Human -DTXSID4047173 Clint NA 1.965 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047173 Fup NA 0.5992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047173 Vd NA 0.5865 L/kg 1compartment NA NA Rat Human +DTXSID4047173 TK.Half.Life NA 5.131 hours 1compartment NA NA Human Human +DTXSID4047173 Css NA 0.5165 mg/L 3compartmentss NA 50% Human Human +DTXSID4047173 Css NA 3.001 mg/L 3compartmentss NA 95% Human Human +DTXSID4047173 Css NA 0.4218 mg/L PBTK NA 50% Human Human +DTXSID4047173 Css NA 1.949 mg/L PBTK NA 95% Human Human +DTXSID4047173 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047173 Fup 0.888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047173 Vd NA 0.7415 L/kg 1compartment NA NA Rat Human DTXSID4047173 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047173 TK.Half.Life NA 0.9 hours 1compartment NA NA Rat Human -DTXSID4047173 Css NA 0.1337 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047173 Css NA 0.9332 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047173 Css NA 0.09862 mg/L PBTK NA 50% Rat Human -DTXSID4047173 Css NA 0.5386 mg/L PBTK NA 95% Rat Human -DTXSID4047179 Clint NA 1144 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047179 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047179 Vd NA 529000 L/kg 1compartment NA NA Human Human -DTXSID4047179 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4047179 TK.Half.Life NA 304800 hours 1compartment NA NA Human Human -DTXSID4047179 Css NA 4.5e-07 mg/L 3compartmentss NA 50% Human Human -DTXSID4047179 Css NA 2.766e-06 mg/L 3compartmentss NA 95% Human Human -DTXSID4047179 Css NA 0.04845 mg/L PBTK NA 50% Human Human -DTXSID4047179 Css NA 0.2706 mg/L PBTK NA 95% Human Human -DTXSID4047179 Clint NA 1144 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047179 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047179 Vd NA 504800 L/kg 1compartment NA NA Rat Human -DTXSID4047179 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID4047179 TK.Half.Life NA 54880 hours 1compartment NA NA Rat Human -DTXSID4047179 Css NA 2.28e-07 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047179 Css NA 9.74e-07 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047179 Css NA 0.02602 mg/L PBTK NA 50% Rat Human -DTXSID4047179 Css NA 0.1082 mg/L PBTK NA 95% Rat Human +DTXSID4047173 TK.Half.Life NA 1.842 hours 1compartment NA NA Rat Human +DTXSID4047173 Css NA 0.002634 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047173 Css NA 0.01648 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047173 Css NA 0.002097 mg/L PBTK NA 50% Rat Human +DTXSID4047173 Css NA 0.01038 mg/L PBTK NA 95% Rat Human +DTXSID4047200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047200 Fup 0.0538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047200 Vd NA 2.995 L/kg 1compartment NA NA Human Human +DTXSID4047200 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4047200 TK.Half.Life NA 40.25 hours 1compartment NA NA Human Human +DTXSID4047200 Css NA 1.599 mg/L 3compartmentss NA 50% Human Human +DTXSID4047200 Css NA 9.979 mg/L 3compartmentss NA 95% Human Human +DTXSID4047200 Css NA 1.099 mg/L PBTK NA 50% Human Human +DTXSID4047200 Css NA 6.616 mg/L PBTK NA 95% Human Human +DTXSID4047200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047200 Fup 0.0538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047200 Vd NA 2.246 L/kg 1compartment NA NA Rat Human +DTXSID4047200 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4047200 TK.Half.Life NA 6.614 hours 1compartment NA NA Rat Human +DTXSID4047200 Css NA 0.2049 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047200 Css NA 1.122 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047200 Css NA 0.1401 mg/L PBTK NA 50% Rat Human +DTXSID4047200 Css NA 0.7462 mg/L PBTK NA 95% Rat Human +DTXSID4047206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047206 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047206 Vd NA 1.17 L/kg 1compartment NA NA Human Human +DTXSID4047206 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047206 TK.Half.Life NA 1.89 hours 1compartment NA NA Human Human +DTXSID4047206 Css NA 0.1034 mg/L 3compartmentss NA 50% Human Human +DTXSID4047206 Css NA 0.7327 mg/L 3compartmentss NA 95% Human Human +DTXSID4047206 Css NA 0.07388 mg/L PBTK NA 50% Human Human +DTXSID4047206 Css NA 0.491 mg/L PBTK NA 95% Human Human +DTXSID4047206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047206 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047206 Vd NA 0.9529 L/kg 1compartment NA NA Rat Human +DTXSID4047206 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047206 TK.Half.Life NA 0.801 hours 1compartment NA NA Rat Human +DTXSID4047206 Css NA 0.01308 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047206 Css NA 0.07023 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047206 Css NA 0.009234 mg/L PBTK NA 50% Rat Human +DTXSID4047206 Css NA 0.04654 mg/L PBTK NA 95% Rat Human DTXSID4047252 Clint 2.09 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4047252 Fup 0.0234 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4047252 Vd NA 0.1846 L/kg 1compartment NA NA Human Human +DTXSID4047252 Vd NA 0.2002 L/kg 1compartment NA NA Human Human DTXSID4047252 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4047252 TK.Half.Life NA 11.55 hours 1compartment NA NA Human Human -DTXSID4047252 Css NA 7.756 mg/L 3compartmentss NA 50% Human Human -DTXSID4047252 Css NA 43.61 mg/L 3compartmentss NA 95% Human Human -DTXSID4047252 Css NA 4.574 mg/L PBTK NA 50% Human Human -DTXSID4047252 Css NA 25 mg/L PBTK NA 95% Human Human +DTXSID4047252 TK.Half.Life NA 12.46 hours 1compartment NA NA Human Human +DTXSID4047252 Css NA 5.382 mg/L 3compartmentss NA 50% Human Human +DTXSID4047252 Css NA 30.29 mg/L 3compartmentss NA 95% Human Human +DTXSID4047252 Css NA 3.157 mg/L PBTK NA 50% Human Human +DTXSID4047252 Css NA 17.53 mg/L PBTK NA 95% Human Human DTXSID4047252 Clint 2.09 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4047252 Fup 0.0234 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4047252 Vd NA 0.1821 L/kg 1compartment NA NA Rat Human +DTXSID4047252 Vd NA 0.1927 L/kg 1compartment NA NA Rat Human DTXSID4047252 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047252 TK.Half.Life NA 6.436 hours 1compartment NA NA Rat Human -DTXSID4047252 Css NA 3.692 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047252 Css NA 15.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047252 Css NA 2.025 mg/L PBTK NA 50% Rat Human -DTXSID4047252 Css NA 8.145 mg/L PBTK NA 95% Rat Human -DTXSID4047254 Clint NA 11.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047254 Fup NA 0.1394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047254 Vd NA 0.2782 L/kg 1compartment NA NA Human Human +DTXSID4047252 TK.Half.Life NA 6.776 hours 1compartment NA NA Rat Human +DTXSID4047252 Css NA 0.07364 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047252 Css NA 0.5145 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047252 Css NA 0.04076 mg/L PBTK NA 50% Rat Human +DTXSID4047252 Css NA 0.2839 mg/L PBTK NA 95% Rat Human +DTXSID4047254 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047254 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047254 Vd NA 0.326 L/kg 1compartment NA NA Human Human DTXSID4047254 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047254 TK.Half.Life NA 0.8944 hours 1compartment NA NA Human Human -DTXSID4047254 Css NA 0.3864 mg/L 3compartmentss NA 50% Human Human -DTXSID4047254 Css NA 2.937 mg/L 3compartmentss NA 95% Human Human -DTXSID4047254 Css NA 0.2392 mg/L PBTK NA 50% Human Human -DTXSID4047254 Css NA 1.766 mg/L PBTK NA 95% Human Human -DTXSID4047254 Clint NA 11.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047254 Fup NA 0.1394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047254 Vd NA 0.2747 L/kg 1compartment NA NA Rat Human +DTXSID4047254 TK.Half.Life NA 1.269 hours 1compartment NA NA Human Human +DTXSID4047254 Css NA 0.4228 mg/L 3compartmentss NA 50% Human Human +DTXSID4047254 Css NA 2.562 mg/L 3compartmentss NA 95% Human Human +DTXSID4047254 Css NA 0.2702 mg/L PBTK NA 50% Human Human +DTXSID4047254 Css NA 1.575 mg/L PBTK NA 95% Human Human +DTXSID4047254 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047254 Fup 0.18 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047254 Vd NA 0.3191 L/kg 1compartment NA NA Rat Human DTXSID4047254 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047254 TK.Half.Life NA 0.5267 hours 1compartment NA NA Rat Human -DTXSID4047254 Css NA 0.2152 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047254 Css NA 1.165 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047254 Css NA 0.1251 mg/L PBTK NA 50% Rat Human -DTXSID4047254 Css NA 0.6511 mg/L PBTK NA 95% Rat Human +DTXSID4047254 TK.Half.Life NA 0.7329 hours 1compartment NA NA Rat Human +DTXSID4047254 Css NA 0.05135 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047254 Css NA 0.2151 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047254 Css NA 0.03204 mg/L PBTK NA 50% Rat Human +DTXSID4047254 Css NA 0.1276 mg/L PBTK NA 95% Rat Human DTXSID4047258 Clint 3.36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4047258 Fup 0.263 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4047258 Vd NA 4.127 L/kg 1compartment NA NA Human Human -DTXSID4047258 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4047258 TK.Half.Life NA 13.79 hours 1compartment NA NA Human Human -DTXSID4047258 Css NA 0.1888 mg/L 3compartmentss NA 50% Human Human -DTXSID4047258 Css NA 1.125 mg/L 3compartmentss NA 95% Human Human -DTXSID4047258 Css NA 0.248 mg/L PBTK NA 50% Human Human -DTXSID4047258 Css NA 1.174 mg/L PBTK NA 95% Human Human +DTXSID4047258 Vd NA 3.134 L/kg 1compartment NA NA Human Human +DTXSID4047258 Days.Css NA 70 Days PBTK NA NA Human Human +DTXSID4047258 TK.Half.Life NA 319.4 hours 1compartment NA NA Human Human +DTXSID4047258 Css NA 12 mg/L 3compartmentss NA 50% Human Human +DTXSID4047258 Css NA 69.88 mg/L 3compartmentss NA 95% Human Human +DTXSID4047258 Css NA 8.387 mg/L PBTK NA 50% Human Human +DTXSID4047258 Css NA 48.12 mg/L PBTK NA 95% Human Human DTXSID4047258 Clint 3.36 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4047258 Fup 0.263 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4047258 Vd NA 4.172 L/kg 1compartment NA NA Rat Human -DTXSID4047258 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047258 TK.Half.Life NA 7.949 hours 1compartment NA NA Rat Human -DTXSID4047258 Css NA 0.09042 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047258 Css NA 0.3906 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047258 Css NA 0.1203 mg/L PBTK NA 50% Rat Human -DTXSID4047258 Css NA 0.3846 mg/L PBTK NA 95% Rat Human -DTXSID4047331 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047331 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047331 Vd NA 3.112 L/kg 1compartment NA NA Human Human -DTXSID4047331 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4047331 TK.Half.Life NA 79530 hours 1compartment NA NA Human Human -DTXSID4047331 Css NA 2926 mg/L 3compartmentss NA 50% Human Human -DTXSID4047331 Css NA 7780 mg/L 3compartmentss NA 95% Human Human -DTXSID4047331 Css NA 2032 mg/L PBTK NA 50% Human Human -DTXSID4047331 Css NA 5061 mg/L PBTK NA 95% Human Human -DTXSID4047331 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047331 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047331 Vd NA 2.332 L/kg 1compartment NA NA Rat Human -DTXSID4047331 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID4047331 TK.Half.Life NA 5034 hours 1compartment NA NA Rat Human -DTXSID4047331 Css NA 795.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047331 Css NA 1773 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047331 Css NA 528.7 mg/L PBTK NA 50% Rat Human -DTXSID4047331 Css NA 1067 mg/L PBTK NA 95% Rat Human -DTXSID4047333 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047333 Fup NA 0.0296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047333 Vd NA 1.335 L/kg 1compartment NA NA Human Human -DTXSID4047333 Days.Css NA 93 Days PBTK NA NA Human Human -DTXSID4047333 TK.Half.Life NA 389.2 hours 1compartment NA NA Human Human -DTXSID4047333 Css NA 46.02 mg/L 3compartmentss NA 50% Human Human -DTXSID4047333 Css NA 238.2 mg/L 3compartmentss NA 95% Human Human -DTXSID4047333 Css NA 28.87 mg/L PBTK NA 50% Human Human -DTXSID4047333 Css NA 140.4 mg/L PBTK NA 95% Human Human -DTXSID4047333 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047333 Fup NA 0.0296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047333 Vd NA 0.9936 L/kg 1compartment NA NA Rat Human -DTXSID4047333 Days.Css NA 21 Days PBTK NA NA Rat Human -DTXSID4047333 TK.Half.Life NA 79.89 hours 1compartment NA NA Rat Human -DTXSID4047333 Css NA 12.87 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047333 Css NA 58.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047333 Css NA 7.565 mg/L PBTK NA 50% Rat Human -DTXSID4047333 Css NA 31.98 mg/L PBTK NA 95% Rat Human -DTXSID4047335 Clint NA 44.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047335 Fup NA 0.1146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047335 Vd NA 3.038 L/kg 1compartment NA NA Human Human -DTXSID4047335 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4047335 TK.Half.Life NA 16.79 hours 1compartment NA NA Human Human -DTXSID4047335 Css NA 0.5994 mg/L 3compartmentss NA 50% Human Human -DTXSID4047335 Css NA 3.705 mg/L 3compartmentss NA 95% Human Human -DTXSID4047335 Css NA 0.4196 mg/L PBTK NA 50% Human Human -DTXSID4047335 Css NA 2.529 mg/L PBTK NA 95% Human Human -DTXSID4047335 Clint NA 44.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047335 Fup NA 0.1146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047335 Vd NA 2.282 L/kg 1compartment NA NA Rat Human +DTXSID4047258 Vd NA 2.351 L/kg 1compartment NA NA Rat Human +DTXSID4047258 Days.Css NA 37 Days PBTK NA NA Rat Human +DTXSID4047258 TK.Half.Life NA 40.18 hours 1compartment NA NA Rat Human +DTXSID4047258 Css NA 1.519 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047258 Css NA 6.63 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047258 Css NA 1.057 mg/L PBTK NA 50% Rat Human +DTXSID4047258 Css NA 4.424 mg/L PBTK NA 95% Rat Human +DTXSID4047331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047331 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047331 Vd NA 2.919 L/kg 1compartment NA NA Human Human +DTXSID4047331 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID4047331 TK.Half.Life NA 63.71 hours 1compartment NA NA Human Human +DTXSID4047331 Css NA 2.474 mg/L 3compartmentss NA 50% Human Human +DTXSID4047331 Css NA 17.91 mg/L 3compartmentss NA 95% Human Human +DTXSID4047331 Css NA 1.677 mg/L PBTK NA 50% Human Human +DTXSID4047331 Css NA 11.71 mg/L PBTK NA 95% Human Human +DTXSID4047331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047331 Fup 0.0112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047331 Vd NA 2.183 L/kg 1compartment NA NA Rat Human +DTXSID4047331 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4047331 TK.Half.Life NA 10.98 hours 1compartment NA NA Rat Human +DTXSID4047331 Css NA 0.1278 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047331 Css NA 0.9175 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047331 Css NA 0.08426 mg/L PBTK NA 50% Rat Human +DTXSID4047331 Css NA 0.5837 mg/L PBTK NA 95% Rat Human +DTXSID4047333 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047333 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047333 Vd NA 0.3029 L/kg 1compartment NA NA Human Human +DTXSID4047333 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047333 TK.Half.Life NA 4.563 hours 1compartment NA NA Human Human +DTXSID4047333 Css NA 2.574 mg/L 3compartmentss NA 50% Human Human +DTXSID4047333 Css NA 20.97 mg/L 3compartmentss NA 95% Human Human +DTXSID4047333 Css NA 1.574 mg/L PBTK NA 50% Human Human +DTXSID4047333 Css NA 12.37 mg/L PBTK NA 95% Human Human +DTXSID4047333 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047333 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047333 Vd NA 0.2889 L/kg 1compartment NA NA Rat Human +DTXSID4047333 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047333 TK.Half.Life NA 2.732 hours 1compartment NA NA Rat Human +DTXSID4047333 Css NA 0.3194 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047333 Css NA 2.044 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047333 Css NA 0.1891 mg/L PBTK NA 50% Rat Human +DTXSID4047333 Css NA 1.163 mg/L PBTK NA 95% Rat Human +DTXSID4047335 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047335 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047335 Vd NA 0.8511 L/kg 1compartment NA NA Human Human +DTXSID4047335 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047335 TK.Half.Life NA 2.245 hours 1compartment NA NA Human Human +DTXSID4047335 Css NA 0.2298 mg/L 3compartmentss NA 50% Human Human +DTXSID4047335 Css NA 1.453 mg/L 3compartmentss NA 95% Human Human +DTXSID4047335 Css NA 0.1672 mg/L PBTK NA 50% Human Human +DTXSID4047335 Css NA 0.9582 mg/L PBTK NA 95% Human Human +DTXSID4047335 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047335 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047335 Vd NA 0.7519 L/kg 1compartment NA NA Rat Human DTXSID4047335 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047335 TK.Half.Life NA 2.921 hours 1compartment NA NA Rat Human -DTXSID4047335 Css NA 0.3332 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047335 Css NA 1.768 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047335 Css NA 0.2236 mg/L PBTK NA 50% Rat Human -DTXSID4047335 Css NA 1.138 mg/L PBTK NA 95% Rat Human -DTXSID4047337 Clint NA 8.886 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047337 Fup NA 0.005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047337 Vd NA 1.739 L/kg 1compartment NA NA Human Human -DTXSID4047337 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID4047337 TK.Half.Life NA 93.29 hours 1compartment NA NA Human Human -DTXSID4047337 Css NA 9.188 mg/L 3compartmentss NA 50% Human Human -DTXSID4047337 Css NA 74.21 mg/L 3compartmentss NA 95% Human Human -DTXSID4047337 Css NA 5.746 mg/L PBTK NA 50% Human Human -DTXSID4047337 Css NA 44.79 mg/L PBTK NA 95% Human Human -DTXSID4047337 Clint NA 8.886 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047337 Fup NA 0.005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047337 Vd NA 1.281 L/kg 1compartment NA NA Rat Human -DTXSID4047337 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID4047337 TK.Half.Life NA 32.71 hours 1compartment NA NA Rat Human -DTXSID4047337 Css NA 5.126 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047337 Css NA 33.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047337 Css NA 3.008 mg/L PBTK NA 50% Rat Human -DTXSID4047337 Css NA 18.99 mg/L PBTK NA 95% Rat Human -DTXSID4047339 Clint NA 52.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047339 Fup NA 0.032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047339 Vd NA 2.555 L/kg 1compartment NA NA Human Human -DTXSID4047339 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047339 TK.Half.Life NA 7.634 hours 1compartment NA NA Human Human -DTXSID4047339 Css NA 0.3248 mg/L 3compartmentss NA 50% Human Human -DTXSID4047339 Css NA 2.595 mg/L 3compartmentss NA 95% Human Human -DTXSID4047339 Css NA 0.2256 mg/L PBTK NA 50% Human Human -DTXSID4047339 Css NA 1.681 mg/L PBTK NA 95% Human Human -DTXSID4047339 Clint NA 52.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047339 Fup NA 0.032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047339 Vd NA 1.996 L/kg 1compartment NA NA Rat Human -DTXSID4047339 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047339 TK.Half.Life NA 2.331 hours 1compartment NA NA Rat Human -DTXSID4047339 Css NA 0.1863 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047339 Css NA 1.148 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047339 Css NA 0.122 mg/L PBTK NA 50% Rat Human -DTXSID4047339 Css NA 0.7026 mg/L PBTK NA 95% Rat Human -DTXSID4047381 Clint NA 35.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047381 Fup NA 0.0446 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047381 Vd NA 1.705 L/kg 1compartment NA NA Human Human +DTXSID4047335 TK.Half.Life NA 1.109 hours 1compartment NA NA Rat Human +DTXSID4047335 Css NA 0.02707 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047335 Css NA 0.125 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047335 Css NA 0.01962 mg/L PBTK NA 50% Rat Human +DTXSID4047335 Css NA 0.08 mg/L PBTK NA 95% Rat Human +DTXSID4047337 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047337 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047337 Vd NA 2.228 L/kg 1compartment NA NA Human Human +DTXSID4047337 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4047337 TK.Half.Life NA 26.05 hours 1compartment NA NA Human Human +DTXSID4047337 Css NA 1.688 mg/L 3compartmentss NA 50% Human Human +DTXSID4047337 Css NA 13.55 mg/L 3compartmentss NA 95% Human Human +DTXSID4047337 Css NA 1.102 mg/L PBTK NA 50% Human Human +DTXSID4047337 Css NA 8.392 mg/L PBTK NA 95% Human Human +DTXSID4047337 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047337 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047337 Vd NA 1.656 L/kg 1compartment NA NA Rat Human +DTXSID4047337 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4047337 TK.Half.Life NA 7.493 hours 1compartment NA NA Rat Human +DTXSID4047337 Css NA 0.2174 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047337 Css NA 1.412 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047337 Css NA 0.1383 mg/L PBTK NA 50% Rat Human +DTXSID4047337 Css NA 0.865 mg/L PBTK NA 95% Rat Human +DTXSID4047339 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047339 Fup 0.0408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047339 Vd NA 2.837 L/kg 1compartment NA NA Human Human +DTXSID4047339 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4047339 TK.Half.Life NA 32.25 hours 1compartment NA NA Human Human +DTXSID4047339 Css NA 1.437 mg/L 3compartmentss NA 50% Human Human +DTXSID4047339 Css NA 9.745 mg/L 3compartmentss NA 95% Human Human +DTXSID4047339 Css NA 0.9731 mg/L PBTK NA 50% Human Human +DTXSID4047339 Css NA 6.463 mg/L PBTK NA 95% Human Human +DTXSID4047339 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047339 Fup 0.0408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047339 Vd NA 2.125 L/kg 1compartment NA NA Rat Human +DTXSID4047339 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4047339 TK.Half.Life NA 6.233 hours 1compartment NA NA Rat Human +DTXSID4047339 Css NA 0.1861 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047339 Css NA 1.037 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047339 Css NA 0.1248 mg/L PBTK NA 50% Rat Human +DTXSID4047339 Css NA 0.6715 mg/L PBTK NA 95% Rat Human +DTXSID4047381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047381 Fup 0.0879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047381 Vd NA 1.968 L/kg 1compartment NA NA Human Human DTXSID4047381 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047381 TK.Half.Life NA 6.118 hours 1compartment NA NA Human Human -DTXSID4047381 Css NA 0.4539 mg/L 3compartmentss NA 50% Human Human -DTXSID4047381 Css NA 3.419 mg/L 3compartmentss NA 95% Human Human -DTXSID4047381 Css NA 0.2943 mg/L PBTK NA 50% Human Human -DTXSID4047381 Css NA 2.15 mg/L PBTK NA 95% Human Human -DTXSID4047381 Clint NA 35.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047381 Fup NA 0.0446 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047381 Vd NA 1.297 L/kg 1compartment NA NA Rat Human +DTXSID4047381 TK.Half.Life NA 6.802 hours 1compartment NA NA Human Human +DTXSID4047381 Css NA 0.3866 mg/L 3compartmentss NA 50% Human Human +DTXSID4047381 Css NA 2.754 mg/L 3compartmentss NA 95% Human Human +DTXSID4047381 Css NA 0.2617 mg/L PBTK NA 50% Human Human +DTXSID4047381 Css NA 1.774 mg/L PBTK NA 95% Human Human +DTXSID4047381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047381 Fup 0.0879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047381 Vd NA 1.518 L/kg 1compartment NA NA Rat Human DTXSID4047381 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047381 TK.Half.Life NA 2.284 hours 1compartment NA NA Rat Human -DTXSID4047381 Css NA 0.2558 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047381 Css NA 1.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047381 Css NA 0.1564 mg/L PBTK NA 50% Rat Human -DTXSID4047381 Css NA 0.9383 mg/L PBTK NA 95% Rat Human -DTXSID4047385 Clint NA 29.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047385 Fup NA 0.1696 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047385 Vd NA 2.365 L/kg 1compartment NA NA Human Human +DTXSID4047381 TK.Half.Life NA 2.394 hours 1compartment NA NA Rat Human +DTXSID4047381 Css NA 0.05013 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047381 Css NA 0.2896 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047381 Css NA 0.03337 mg/L PBTK NA 50% Rat Human +DTXSID4047381 Css NA 0.1826 mg/L PBTK NA 95% Rat Human +DTXSID4047383 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047383 Fup 0.0791 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047383 Vd NA 0.3518 L/kg 1compartment NA NA Human Human +DTXSID4047383 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047383 TK.Half.Life NA 1.072 hours 1compartment NA NA Human Human +DTXSID4047383 Css NA 0.3182 mg/L 3compartmentss NA 50% Human Human +DTXSID4047383 Css NA 2.796 mg/L 3compartmentss NA 95% Human Human +DTXSID4047383 Css NA 0.2018 mg/L PBTK NA 50% Human Human +DTXSID4047383 Css NA 1.693 mg/L PBTK NA 95% Human Human +DTXSID4047383 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047383 Fup 0.0791 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047383 Vd NA 0.3425 L/kg 1compartment NA NA Rat Human +DTXSID4047383 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047383 TK.Half.Life NA 0.6353 hours 1compartment NA NA Rat Human +DTXSID4047383 Css NA 0.0157 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047383 Css NA 0.1361 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047383 Css NA 0.009625 mg/L PBTK NA 50% Rat Human +DTXSID4047383 Css NA 0.07886 mg/L PBTK NA 95% Rat Human +DTXSID4047385 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047385 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047385 Vd NA 0.7075 L/kg 1compartment NA NA Human Human DTXSID4047385 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047385 TK.Half.Life NA 4.874 hours 1compartment NA NA Human Human -DTXSID4047385 Css NA 0.1666 mg/L 3compartmentss NA 50% Human Human -DTXSID4047385 Css NA 1.028 mg/L 3compartmentss NA 95% Human Human -DTXSID4047385 Css NA 0.1214 mg/L PBTK NA 50% Human Human -DTXSID4047385 Css NA 0.7072 mg/L PBTK NA 95% Human Human -DTXSID4047385 Clint NA 29.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047385 Fup NA 0.1696 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047385 Vd NA 1.843 L/kg 1compartment NA NA Rat Human +DTXSID4047385 TK.Half.Life NA 2.048 hours 1compartment NA NA Human Human +DTXSID4047385 Css NA 0.2292 mg/L 3compartmentss NA 50% Human Human +DTXSID4047385 Css NA 1.423 mg/L 3compartmentss NA 95% Human Human +DTXSID4047385 Css NA 0.1622 mg/L PBTK NA 50% Human Human +DTXSID4047385 Css NA 0.9301 mg/L PBTK NA 95% Human Human +DTXSID4047385 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047385 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047385 Vd NA 0.6789 L/kg 1compartment NA NA Rat Human DTXSID4047385 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047385 TK.Half.Life NA 1.556 hours 1compartment NA NA Rat Human -DTXSID4047385 Css NA 0.09163 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047385 Css NA 0.4602 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047385 Css NA 0.06405 mg/L PBTK NA 50% Rat Human -DTXSID4047385 Css NA 0.2987 mg/L PBTK NA 95% Rat Human -DTXSID4047387 Clint NA 75.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047387 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047387 Vd NA 3.068 L/kg 1compartment NA NA Human Human -DTXSID4047387 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4047387 TK.Half.Life NA 24.04 hours 1compartment NA NA Human Human -DTXSID4047387 Css NA 0.8911 mg/L 3compartmentss NA 50% Human Human -DTXSID4047387 Css NA 5.838 mg/L 3compartmentss NA 95% Human Human -DTXSID4047387 Css NA 0.6178 mg/L PBTK NA 50% Human Human -DTXSID4047387 Css NA 3.906 mg/L PBTK NA 95% Human Human -DTXSID4047387 Clint NA 75.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047387 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047387 Vd NA 2.298 L/kg 1compartment NA NA Rat Human -DTXSID4047387 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4047387 TK.Half.Life NA 3.823 hours 1compartment NA NA Rat Human -DTXSID4047387 Css NA 0.5052 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047387 Css NA 2.695 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047387 Css NA 0.3324 mg/L PBTK NA 50% Rat Human -DTXSID4047387 Css NA 1.716 mg/L PBTK NA 95% Rat Human -DTXSID4047389 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047389 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047389 Vd NA 3.083 L/kg 1compartment NA NA Human Human -DTXSID4047389 Days.Css NA 714 Days PBTK NA NA Human Human -DTXSID4047389 TK.Half.Life NA 2683 hours 1compartment NA NA Human Human -DTXSID4047389 Css NA 98.04 mg/L 3compartmentss NA 50% Human Human -DTXSID4047389 Css NA 280.4 mg/L 3compartmentss NA 95% Human Human -DTXSID4047389 Css NA 69.6 mg/L PBTK NA 50% Human Human -DTXSID4047389 Css NA 181.8 mg/L PBTK NA 95% Human Human -DTXSID4047389 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047389 Fup NA 0.1647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047389 Vd NA 2.323 L/kg 1compartment NA NA Rat Human -DTXSID4047389 Days.Css NA 181 Days PBTK NA NA Rat Human -DTXSID4047389 TK.Half.Life NA 187.9 hours 1compartment NA NA Rat Human -DTXSID4047389 Css NA 26.45 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047389 Css NA 59.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047389 Css NA 17.94 mg/L PBTK NA 50% Rat Human -DTXSID4047389 Css NA 36.07 mg/L PBTK NA 95% Rat Human -DTXSID4047410 Clint NA 33.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047410 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047410 Vd NA 4.255 L/kg 1compartment NA NA Human Human -DTXSID4047410 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID4047410 TK.Half.Life NA 84.05 hours 1compartment NA NA Human Human -DTXSID4047410 Css NA 2.05 mg/L 3compartmentss NA 50% Human Human -DTXSID4047410 Css NA 11.46 mg/L 3compartmentss NA 95% Human Human -DTXSID4047410 Css NA 1.573 mg/L PBTK NA 50% Human Human -DTXSID4047410 Css NA 8.557 mg/L PBTK NA 95% Human Human -DTXSID4047410 Clint NA 33.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047410 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047410 Vd NA 3.226 L/kg 1compartment NA NA Rat Human -DTXSID4047410 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID4047410 TK.Half.Life NA 11.58 hours 1compartment NA NA Rat Human -DTXSID4047410 Css NA 1.159 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047410 Css NA 5.004 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047410 Css NA 0.8514 mg/L PBTK NA 50% Rat Human -DTXSID4047410 Css NA 3.72 mg/L PBTK NA 95% Rat Human -DTXSID4047412 Clint NA 47.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047412 Fup NA 0.1924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047412 Vd NA 1.693 L/kg 1compartment NA NA Human Human +DTXSID4047385 TK.Half.Life NA 1.132 hours 1compartment NA NA Rat Human +DTXSID4047385 Css NA 0.01025 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047385 Css NA 0.07413 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047385 Css NA 0.007226 mg/L PBTK NA 50% Rat Human +DTXSID4047385 Css NA 0.04704 mg/L PBTK NA 95% Rat Human +DTXSID4047387 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047387 Fup 0.0949 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047387 Vd NA 0.2808 L/kg 1compartment NA NA Human Human +DTXSID4047387 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047387 TK.Half.Life NA 0.763 hours 1compartment NA NA Human Human +DTXSID4047387 Css NA 0.2682 mg/L 3compartmentss NA 50% Human Human +DTXSID4047387 Css NA 2.191 mg/L 3compartmentss NA 95% Human Human +DTXSID4047387 Css NA 0.1636 mg/L PBTK NA 50% Human Human +DTXSID4047387 Css NA 1.308 mg/L PBTK NA 95% Human Human +DTXSID4047387 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047387 Fup 0.0949 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047387 Vd NA 0.2804 L/kg 1compartment NA NA Rat Human +DTXSID4047387 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047387 TK.Half.Life NA 0.4542 hours 1compartment NA NA Rat Human +DTXSID4047387 Css NA 0.01336 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047387 Css NA 0.1174 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047387 Css NA 0.007824 mg/L PBTK NA 50% Rat Human +DTXSID4047387 Css NA 0.06694 mg/L PBTK NA 95% Rat Human +DTXSID4047389 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047389 Fup 0.0539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047389 Vd NA 0.916 L/kg 1compartment NA NA Human Human +DTXSID4047389 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047389 TK.Half.Life NA 10.39 hours 1compartment NA NA Human Human +DTXSID4047389 Css NA 1.539 mg/L 3compartmentss NA 50% Human Human +DTXSID4047389 Css NA 11.21 mg/L 3compartmentss NA 95% Human Human +DTXSID4047389 Css NA 0.9668 mg/L PBTK NA 50% Human Human +DTXSID4047389 Css NA 6.712 mg/L PBTK NA 95% Human Human +DTXSID4047389 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047389 Fup 0.0539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047389 Vd NA 0.7019 L/kg 1compartment NA NA Rat Human +DTXSID4047389 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047389 TK.Half.Life NA 4.578 hours 1compartment NA NA Rat Human +DTXSID4047389 Css NA 0.07196 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047389 Css NA 0.5615 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047389 Css NA 0.04368 mg/L PBTK NA 50% Rat Human +DTXSID4047389 Css NA 0.3274 mg/L PBTK NA 95% Rat Human +DTXSID4047410 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047410 Fup 0.0107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047410 Vd NA 7.928 L/kg 1compartment NA NA Human Human +DTXSID4047410 Days.Css NA 47 Days PBTK NA NA Human Human +DTXSID4047410 TK.Half.Life NA 238.4 hours 1compartment NA NA Human Human +DTXSID4047410 Css NA 2.316 mg/L 3compartmentss NA 50% Human Human +DTXSID4047410 Css NA 14.46 mg/L 3compartmentss NA 95% Human Human +DTXSID4047410 Css NA 2.376 mg/L PBTK NA 50% Human Human +DTXSID4047410 Css NA 14.44 mg/L PBTK NA 95% Human Human +DTXSID4047410 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047410 Fup 0.0107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047410 Vd NA 6.179 L/kg 1compartment NA NA Rat Human +DTXSID4047410 Days.Css NA 28 Days PBTK NA NA Rat Human +DTXSID4047410 TK.Half.Life NA 33.2 hours 1compartment NA NA Rat Human +DTXSID4047410 Css NA 0.2964 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047410 Css NA 1.444 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047410 Css NA 0.3084 mg/L PBTK NA 50% Rat Human +DTXSID4047410 Css NA 1.553 mg/L PBTK NA 95% Rat Human +DTXSID4047412 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047412 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047412 Vd NA 1.346 L/kg 1compartment NA NA Human Human DTXSID4047412 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047412 TK.Half.Life NA 2.2 hours 1compartment NA NA Human Human -DTXSID4047412 Css NA 0.06701 mg/L 3compartmentss NA 50% Human Human -DTXSID4047412 Css NA 0.4695 mg/L 3compartmentss NA 95% Human Human -DTXSID4047412 Css NA 0.04816 mg/L PBTK NA 50% Human Human -DTXSID4047412 Css NA 0.3188 mg/L PBTK NA 95% Human Human -DTXSID4047412 Clint NA 47.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047412 Fup NA 0.1924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047412 Vd NA 1.318 L/kg 1compartment NA NA Rat Human +DTXSID4047412 TK.Half.Life NA 2.935 hours 1compartment NA NA Human Human +DTXSID4047412 Css NA 0.2006 mg/L 3compartmentss NA 50% Human Human +DTXSID4047412 Css NA 1.545 mg/L 3compartmentss NA 95% Human Human +DTXSID4047412 Css NA 0.1365 mg/L PBTK NA 50% Human Human +DTXSID4047412 Css NA 0.9808 mg/L PBTK NA 95% Human Human +DTXSID4047412 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047412 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047412 Vd NA 1.052 L/kg 1compartment NA NA Rat Human DTXSID4047412 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047412 TK.Half.Life NA 0.7999 hours 1compartment NA NA Rat Human -DTXSID4047412 Css NA 0.03696 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047412 Css NA 0.1938 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047412 Css NA 0.02539 mg/L PBTK NA 50% Rat Human -DTXSID4047412 Css NA 0.1277 mg/L PBTK NA 95% Rat Human -DTXSID4047464 Clint NA 0.4551 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047464 Fup NA 0.7679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047464 Vd NA 1.215 L/kg 1compartment NA NA Human Human -DTXSID4047464 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047464 TK.Half.Life NA 6.301 hours 1compartment NA NA Human Human -DTXSID4047464 Css NA 0.5452 mg/L 3compartmentss NA 50% Human Human -DTXSID4047464 Css NA 3.429 mg/L 3compartmentss NA 95% Human Human -DTXSID4047464 Css NA 0.4866 mg/L PBTK NA 50% Human Human -DTXSID4047464 Css NA 2.282 mg/L PBTK NA 95% Human Human -DTXSID4047464 Clint NA 0.4551 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047464 Fup NA 0.7679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047464 Vd NA 1.128 L/kg 1compartment NA NA Rat Human +DTXSID4047412 TK.Half.Life NA 1.185 hours 1compartment NA NA Rat Human +DTXSID4047412 Css NA 0.02578 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047412 Css NA 0.1529 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047412 Css NA 0.01714 mg/L PBTK NA 50% Rat Human +DTXSID4047412 Css NA 0.09518 mg/L PBTK NA 95% Rat Human +DTXSID4047418 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047418 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047418 Vd NA 2.573 L/kg 1compartment NA NA Human Human +DTXSID4047418 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047418 TK.Half.Life NA 5.059 hours 1compartment NA NA Human Human +DTXSID4047418 Css NA 0.1426 mg/L 3compartmentss NA 50% Human Human +DTXSID4047418 Css NA 0.9165 mg/L 3compartmentss NA 95% Human Human +DTXSID4047418 Css NA 0.1075 mg/L PBTK NA 50% Human Human +DTXSID4047418 Css NA 0.6618 mg/L PBTK NA 95% Human Human +DTXSID4047418 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047418 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047418 Vd NA 1.98 L/kg 1compartment NA NA Rat Human +DTXSID4047418 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047418 TK.Half.Life NA 1.418 hours 1compartment NA NA Rat Human +DTXSID4047418 Css NA 0.01783 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047418 Css NA 0.08855 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047418 Css NA 0.01352 mg/L PBTK NA 50% Rat Human +DTXSID4047418 Css NA 0.06419 mg/L PBTK NA 95% Rat Human +DTXSID4047464 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047464 Fup 0.638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047464 Vd NA 1.089 L/kg 1compartment NA NA Human Human +DTXSID4047464 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4047464 TK.Half.Life NA 11.65 hours 1compartment NA NA Human Human +DTXSID4047464 Css NA 1.1 mg/L 3compartmentss NA 50% Human Human +DTXSID4047464 Css NA 7.257 mg/L 3compartmentss NA 95% Human Human +DTXSID4047464 Css NA 0.9444 mg/L PBTK NA 50% Human Human +DTXSID4047464 Css NA 4.798 mg/L PBTK NA 95% Human Human +DTXSID4047464 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047464 Fup 0.638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047464 Vd NA 1.008 L/kg 1compartment NA NA Rat Human DTXSID4047464 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047464 TK.Half.Life NA 2.418 hours 1compartment NA NA Rat Human -DTXSID4047464 Css NA 0.1772 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047464 Css NA 1.219 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047464 Css NA 0.1557 mg/L PBTK NA 50% Rat Human -DTXSID4047464 Css NA 0.7433 mg/L PBTK NA 95% Rat Human -DTXSID4047466 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047466 Fup NA 0.9181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047466 Vd NA 0.9091 L/kg 1compartment NA NA Human Human +DTXSID4047464 TK.Half.Life NA 3.529 hours 1compartment NA NA Rat Human +DTXSID4047464 Css NA 0.0665 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047464 Css NA 0.4121 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047464 Css NA 0.05726 mg/L PBTK NA 50% Rat Human +DTXSID4047464 Css NA 0.2578 mg/L PBTK NA 95% Rat Human +DTXSID4047466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047466 Fup 0.744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047466 Vd NA 0.8009 L/kg 1compartment NA NA Human Human DTXSID4047466 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047466 TK.Half.Life NA 6.454 hours 1compartment NA NA Human Human -DTXSID4047466 Css NA 0.8394 mg/L 3compartmentss NA 50% Human Human -DTXSID4047466 Css NA 3.305 mg/L 3compartmentss NA 95% Human Human -DTXSID4047466 Css NA 0.7302 mg/L PBTK NA 50% Human Human -DTXSID4047466 Css NA 2.343 mg/L PBTK NA 95% Human Human -DTXSID4047466 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047466 Fup NA 0.9181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047466 Vd NA 0.9183 L/kg 1compartment NA NA Rat Human +DTXSID4047466 TK.Half.Life NA 7.008 hours 1compartment NA NA Human Human +DTXSID4047466 Css NA 0.8682 mg/L 3compartmentss NA 50% Human Human +DTXSID4047466 Css NA 5.45 mg/L 3compartmentss NA 95% Human Human +DTXSID4047466 Css NA 0.7233 mg/L PBTK NA 50% Human Human +DTXSID4047466 Css NA 3.517 mg/L PBTK NA 95% Human Human +DTXSID4047466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047466 Fup 0.744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047466 Vd NA 0.8087 L/kg 1compartment NA NA Rat Human DTXSID4047466 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047466 TK.Half.Life NA 2.21 hours 1compartment NA NA Rat Human -DTXSID4047466 Css NA 0.217 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047466 Css NA 0.7807 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047466 Css NA 0.1841 mg/L PBTK NA 50% Rat Human -DTXSID4047466 Css NA 0.5087 mg/L PBTK NA 95% Rat Human -DTXSID4047468 Clint NA 31.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047468 Fup NA 0.0879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047468 Vd NA 2.452 L/kg 1compartment NA NA Human Human -DTXSID4047468 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047468 TK.Half.Life NA 8.515 hours 1compartment NA NA Human Human -DTXSID4047468 Css NA 0.3872 mg/L 3compartmentss NA 50% Human Human -DTXSID4047468 Css NA 2.572 mg/L 3compartmentss NA 95% Human Human -DTXSID4047468 Css NA 0.2641 mg/L PBTK NA 50% Human Human -DTXSID4047468 Css NA 1.661 mg/L PBTK NA 95% Human Human -DTXSID4047468 Clint NA 31.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047468 Fup NA 0.0879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047468 Vd NA 1.846 L/kg 1compartment NA NA Rat Human -DTXSID4047468 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047468 TK.Half.Life NA 2.329 hours 1compartment NA NA Rat Human -DTXSID4047468 Css NA 0.2127 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047468 Css NA 1.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047468 Css NA 0.138 mg/L PBTK NA 50% Rat Human -DTXSID4047468 Css NA 0.7296 mg/L PBTK NA 95% Rat Human -DTXSID4047543 Clint NA 14.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047543 Fup NA 0.065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047543 Vd NA 1.101 L/kg 1compartment NA NA Human Human +DTXSID4047466 TK.Half.Life NA 2.399 hours 1compartment NA NA Rat Human +DTXSID4047466 Css NA 0.01641 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047466 Css NA 0.1397 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047466 Css NA 0.01324 mg/L PBTK NA 50% Rat Human +DTXSID4047466 Css NA 0.0884 mg/L PBTK NA 95% Rat Human +DTXSID4047468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047468 Fup 0.0296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047468 Vd NA 2.389 L/kg 1compartment NA NA Human Human +DTXSID4047468 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4047468 TK.Half.Life NA 22.14 hours 1compartment NA NA Human Human +DTXSID4047468 Css NA 1.273 mg/L 3compartmentss NA 50% Human Human +DTXSID4047468 Css NA 9.841 mg/L 3compartmentss NA 95% Human Human +DTXSID4047468 Css NA 0.8412 mg/L PBTK NA 50% Human Human +DTXSID4047468 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID4047468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047468 Fup 0.0296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047468 Vd NA 1.784 L/kg 1compartment NA NA Rat Human +DTXSID4047468 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4047468 TK.Half.Life NA 5.909 hours 1compartment NA NA Rat Human +DTXSID4047468 Css NA 0.1639 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047468 Css NA 0.9919 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047468 Css NA 0.1068 mg/L PBTK NA 50% Rat Human +DTXSID4047468 Css NA 0.6172 mg/L PBTK NA 95% Rat Human +DTXSID4047543 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047543 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047543 Vd NA 1.54 L/kg 1compartment NA NA Human Human DTXSID4047543 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047543 TK.Half.Life NA 5.415 hours 1compartment NA NA Human Human -DTXSID4047543 Css NA 0.6769 mg/L 3compartmentss NA 50% Human Human -DTXSID4047543 Css NA 4.655 mg/L 3compartmentss NA 95% Human Human -DTXSID4047543 Css NA 0.4288 mg/L PBTK NA 50% Human Human -DTXSID4047543 Css NA 2.882 mg/L PBTK NA 95% Human Human -DTXSID4047543 Clint NA 14.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047543 Fup NA 0.065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047543 Vd NA 0.8439 L/kg 1compartment NA NA Rat Human +DTXSID4047543 TK.Half.Life NA 3.667 hours 1compartment NA NA Human Human +DTXSID4047543 Css NA 0.2287 mg/L 3compartmentss NA 50% Human Human +DTXSID4047543 Css NA 1.784 mg/L 3compartmentss NA 95% Human Human +DTXSID4047543 Css NA 0.1554 mg/L PBTK NA 50% Human Human +DTXSID4047543 Css NA 1.131 mg/L PBTK NA 95% Human Human +DTXSID4047543 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047543 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047543 Vd NA 1.189 L/kg 1compartment NA NA Rat Human DTXSID4047543 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047543 TK.Half.Life NA 2.335 hours 1compartment NA NA Rat Human -DTXSID4047543 Css NA 0.3747 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047543 Css NA 1.97 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047543 Css NA 0.2238 mg/L PBTK NA 50% Rat Human -DTXSID4047543 Css NA 1.13 mg/L PBTK NA 95% Rat Human -DTXSID4047545 Clint NA 1.581 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047545 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047545 Vd NA 0.3978 L/kg 1compartment NA NA Human Human -DTXSID4047545 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID4047545 TK.Half.Life NA 33.73 hours 1compartment NA NA Human Human -DTXSID4047545 Css NA 14.36 mg/L 3compartmentss NA 50% Human Human -DTXSID4047545 Css NA 106.7 mg/L 3compartmentss NA 95% Human Human -DTXSID4047545 Css NA 8.954 mg/L PBTK NA 50% Human Human -DTXSID4047545 Css NA 62.71 mg/L PBTK NA 95% Human Human -DTXSID4047545 Clint NA 1.581 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047545 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047545 Vd NA 0.3622 L/kg 1compartment NA NA Rat Human -DTXSID4047545 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4047545 TK.Half.Life NA 16.66 hours 1compartment NA NA Rat Human -DTXSID4047545 Css NA 6.544 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047545 Css NA 40.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047545 Css NA 3.796 mg/L PBTK NA 50% Rat Human -DTXSID4047545 Css NA 22.01 mg/L PBTK NA 95% Rat Human -DTXSID4047547 Clint NA 7.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047547 Fup NA 0.2062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047547 Vd NA 2.434 L/kg 1compartment NA NA Human Human +DTXSID4047543 TK.Half.Life NA 1.411 hours 1compartment NA NA Rat Human +DTXSID4047543 Css NA 0.02909 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047543 Css NA 0.1767 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047543 Css NA 0.01942 mg/L PBTK NA 50% Rat Human +DTXSID4047543 Css NA 0.1117 mg/L PBTK NA 95% Rat Human +DTXSID4047545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047545 Fup 0.0438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047545 Vd NA 0.6098 L/kg 1compartment NA NA Human Human +DTXSID4047545 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047545 TK.Half.Life NA 2.837 hours 1compartment NA NA Human Human +DTXSID4047545 Css NA 0.6178 mg/L 3compartmentss NA 50% Human Human +DTXSID4047545 Css NA 5.981 mg/L 3compartmentss NA 95% Human Human +DTXSID4047545 Css NA 0.4116 mg/L PBTK NA 50% Human Human +DTXSID4047545 Css NA 3.744 mg/L PBTK NA 95% Human Human +DTXSID4047545 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047545 Fup 0.0438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047545 Vd NA 0.5527 L/kg 1compartment NA NA Rat Human +DTXSID4047545 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047545 TK.Half.Life NA 1.618 hours 1compartment NA NA Rat Human +DTXSID4047545 Css NA 0.08269 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047545 Css NA 0.5968 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047545 Css NA 0.05337 mg/L PBTK NA 50% Rat Human +DTXSID4047545 Css NA 0.354 mg/L PBTK NA 95% Rat Human +DTXSID4047547 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047547 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047547 Vd NA 3.432 L/kg 1compartment NA NA Human Human DTXSID4047547 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047547 TK.Half.Life NA 7.502 hours 1compartment NA NA Human Human -DTXSID4047547 Css NA 0.2546 mg/L 3compartmentss NA 50% Human Human -DTXSID4047547 Css NA 1.564 mg/L 3compartmentss NA 95% Human Human -DTXSID4047547 Css NA 0.2233 mg/L PBTK NA 50% Human Human -DTXSID4047547 Css NA 1.203 mg/L PBTK NA 95% Human Human -DTXSID4047547 Clint NA 7.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047547 Fup NA 0.2062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047547 Vd NA 2.264 L/kg 1compartment NA NA Rat Human +DTXSID4047547 TK.Half.Life NA 11.87 hours 1compartment NA NA Human Human +DTXSID4047547 Css NA 0.297 mg/L 3compartmentss NA 50% Human Human +DTXSID4047547 Css NA 1.93 mg/L 3compartmentss NA 95% Human Human +DTXSID4047547 Css NA 0.2349 mg/L PBTK NA 50% Human Human +DTXSID4047547 Css NA 1.443 mg/L PBTK NA 95% Human Human +DTXSID4047547 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047547 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047547 Vd NA 2.754 L/kg 1compartment NA NA Rat Human DTXSID4047547 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047547 TK.Half.Life NA 3.719 hours 1compartment NA NA Rat Human -DTXSID4047547 Css NA 0.1308 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047547 Css NA 0.6166 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047547 Css NA 0.1114 mg/L PBTK NA 50% Rat Human -DTXSID4047547 Css NA 0.4515 mg/L PBTK NA 95% Rat Human -DTXSID4047549 Clint NA 0.3685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047549 Fup NA 0.6068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047549 Vd NA 0.9395 L/kg 1compartment NA NA Human Human -DTXSID4047549 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047549 TK.Half.Life NA 6.466 hours 1compartment NA NA Human Human -DTXSID4047549 Css NA 0.7206 mg/L 3compartmentss NA 50% Human Human -DTXSID4047549 Css NA 5.087 mg/L 3compartmentss NA 95% Human Human -DTXSID4047549 Css NA 0.6018 mg/L PBTK NA 50% Human Human -DTXSID4047549 Css NA 3.219 mg/L PBTK NA 95% Human Human -DTXSID4047549 Clint NA 0.3685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047549 Fup NA 0.6068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047549 Vd NA 0.892 L/kg 1compartment NA NA Rat Human +DTXSID4047547 TK.Half.Life NA 2.508 hours 1compartment NA NA Rat Human +DTXSID4047547 Css NA 0.03714 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047547 Css NA 0.1969 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047547 Css NA 0.02947 mg/L PBTK NA 50% Rat Human +DTXSID4047547 Css NA 0.1477 mg/L PBTK NA 95% Rat Human +DTXSID4047549 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047549 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047549 Vd NA 1.492 L/kg 1compartment NA NA Human Human +DTXSID4047549 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4047549 TK.Half.Life NA 24.55 hours 1compartment NA NA Human Human +DTXSID4047549 Css NA 1.631 mg/L 3compartmentss NA 50% Human Human +DTXSID4047549 Css NA 7.476 mg/L 3compartmentss NA 95% Human Human +DTXSID4047549 Css NA 1.351 mg/L PBTK NA 50% Human Human +DTXSID4047549 Css NA 4.967 mg/L PBTK NA 95% Human Human +DTXSID4047549 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047549 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047549 Vd NA 1.257 L/kg 1compartment NA NA Rat Human DTXSID4047549 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047549 TK.Half.Life NA 2.524 hours 1compartment NA NA Rat Human -DTXSID4047549 Css NA 0.2412 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047549 Css NA 1.677 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047549 Css NA 0.1948 mg/L PBTK NA 50% Rat Human -DTXSID4047549 Css NA 0.9953 mg/L PBTK NA 95% Rat Human -DTXSID4047597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047597 Fup NA 0.9281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047597 Vd NA 0.7679 L/kg 1compartment NA NA Human Human -DTXSID4047597 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047597 TK.Half.Life NA 5.357 hours 1compartment NA NA Human Human -DTXSID4047597 Css NA 0.9064 mg/L 3compartmentss NA 50% Human Human -DTXSID4047597 Css NA 5.128 mg/L 3compartmentss NA 95% Human Human -DTXSID4047597 Css NA 0.7542 mg/L PBTK NA 50% Human Human -DTXSID4047597 Css NA 3.321 mg/L PBTK NA 95% Human Human -DTXSID4047597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047597 Fup NA 0.9281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047597 Vd NA 0.8009 L/kg 1compartment NA NA Rat Human -DTXSID4047597 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047597 TK.Half.Life NA 1.903 hours 1compartment NA NA Rat Human -DTXSID4047597 Css NA 0.2312 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047597 Css NA 1.264 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047597 Css NA 0.1873 mg/L PBTK NA 50% Rat Human -DTXSID4047597 Css NA 0.7661 mg/L PBTK NA 95% Rat Human -DTXSID4047620 Clint NA 1.663 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047620 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047620 Vd NA 1.003 L/kg 1compartment NA NA Human Human +DTXSID4047549 TK.Half.Life NA 6.075 hours 1compartment NA NA Rat Human +DTXSID4047549 Css NA 0.1011 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047549 Css NA 0.42 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047549 Css NA 0.08416 mg/L PBTK NA 50% Rat Human +DTXSID4047549 Css NA 0.2707 mg/L PBTK NA 95% Rat Human +DTXSID4047591 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047591 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047591 Vd NA 2.997 L/kg 1compartment NA NA Human Human +DTXSID4047591 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID4047591 TK.Half.Life NA 64.84 hours 1compartment NA NA Human Human +DTXSID4047591 Css NA 2.697 mg/L 3compartmentss NA 50% Human Human +DTXSID4047591 Css NA 18.44 mg/L 3compartmentss NA 95% Human Human +DTXSID4047591 Css NA 1.844 mg/L PBTK NA 50% Human Human +DTXSID4047591 Css NA 12.05 mg/L PBTK NA 95% Human Human +DTXSID4047591 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047591 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047591 Vd NA 2.244 L/kg 1compartment NA NA Rat Human +DTXSID4047591 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4047591 TK.Half.Life NA 10.3 hours 1compartment NA NA Rat Human +DTXSID4047591 Css NA 0.3484 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047591 Css NA 2.002 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047591 Css NA 0.2358 mg/L PBTK NA 50% Rat Human +DTXSID4047591 Css NA 1.341 mg/L PBTK NA 95% Rat Human +DTXSID4047620 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047620 Fup 0.72 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047620 Vd NA 0.8197 L/kg 1compartment NA NA Human Human DTXSID4047620 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047620 TK.Half.Life NA 2.036 hours 1compartment NA NA Human Human -DTXSID4047620 Css NA 0.2144 mg/L 3compartmentss NA 50% Human Human -DTXSID4047620 Css NA 1.655 mg/L 3compartmentss NA 95% Human Human -DTXSID4047620 Css NA 0.1891 mg/L PBTK NA 50% Human Human -DTXSID4047620 Css NA 1.126 mg/L PBTK NA 95% Human Human -DTXSID4047620 Clint NA 1.663 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047620 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047620 Vd NA 1.005 L/kg 1compartment NA NA Rat Human +DTXSID4047620 TK.Half.Life NA 7.428 hours 1compartment NA NA Human Human +DTXSID4047620 Css NA 0.8757 mg/L 3compartmentss NA 50% Human Human +DTXSID4047620 Css NA 5.873 mg/L 3compartmentss NA 95% Human Human +DTXSID4047620 Css NA 0.7376 mg/L PBTK NA 50% Human Human +DTXSID4047620 Css NA 3.759 mg/L PBTK NA 95% Human Human +DTXSID4047620 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047620 Fup 0.72 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047620 Vd NA 0.8197 L/kg 1compartment NA NA Rat Human DTXSID4047620 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047620 TK.Half.Life NA 1.027 hours 1compartment NA NA Rat Human -DTXSID4047620 Css NA 0.0866 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047620 Css NA 0.6154 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047620 Css NA 0.07602 mg/L PBTK NA 50% Rat Human -DTXSID4047620 Css NA 0.3766 mg/L PBTK NA 95% Rat Human -DTXSID4047622 Clint NA 26.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047622 Fup NA 0.0235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047622 Vd NA 3.126 L/kg 1compartment NA NA Human Human -DTXSID4047622 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID4047622 TK.Half.Life NA 78.77 hours 1compartment NA NA Human Human -DTXSID4047622 Css NA 2.875 mg/L 3compartmentss NA 50% Human Human -DTXSID4047622 Css NA 16.36 mg/L 3compartmentss NA 95% Human Human -DTXSID4047622 Css NA 2.016 mg/L PBTK NA 50% Human Human -DTXSID4047622 Css NA 11.19 mg/L PBTK NA 95% Human Human -DTXSID4047622 Clint NA 26.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047622 Fup NA 0.0235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047622 Vd NA 2.342 L/kg 1compartment NA NA Rat Human -DTXSID4047622 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID4047622 TK.Half.Life NA 10.57 hours 1compartment NA NA Rat Human -DTXSID4047622 Css NA 1.641 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047622 Css NA 6.879 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047622 Css NA 1.094 mg/L PBTK NA 50% Rat Human -DTXSID4047622 Css NA 4.611 mg/L PBTK NA 95% Rat Human -DTXSID4047624 Clint NA 4.764 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047624 Fup NA 0.0287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047624 Vd NA 3.122 L/kg 1compartment NA NA Human Human -DTXSID4047624 Days.Css NA 89 Days PBTK NA NA Human Human -DTXSID4047624 TK.Half.Life NA 395.2 hours 1compartment NA NA Human Human -DTXSID4047624 Css NA 15.6 mg/L 3compartmentss NA 50% Human Human -DTXSID4047624 Css NA 90.34 mg/L 3compartmentss NA 95% Human Human -DTXSID4047624 Css NA 10.83 mg/L PBTK NA 50% Human Human -DTXSID4047624 Css NA 62.01 mg/L PBTK NA 95% Human Human -DTXSID4047624 Clint NA 4.764 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047624 Fup NA 0.0287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047624 Vd NA 2.339 L/kg 1compartment NA NA Rat Human -DTXSID4047624 Days.Css NA 49 Days PBTK NA NA Rat Human -DTXSID4047624 TK.Half.Life NA 51.08 hours 1compartment NA NA Rat Human -DTXSID4047624 Css NA 8.752 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047624 Css NA 39.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047624 Css NA 5.813 mg/L PBTK NA 50% Rat Human -DTXSID4047624 Css NA 25.34 mg/L PBTK NA 95% Rat Human -DTXSID4047670 Clint NA 8.695 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047670 Fup NA 0.8731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047670 Vd NA 1.271 L/kg 1compartment NA NA Human Human -DTXSID4047670 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047670 TK.Half.Life NA 1.237 hours 1compartment NA NA Human Human -DTXSID4047670 Css NA 0.06042 mg/L 3compartmentss NA 50% Human Human -DTXSID4047670 Css NA 0.5592 mg/L 3compartmentss NA 95% Human Human -DTXSID4047670 Css NA 0.054 mg/L PBTK NA 50% Human Human -DTXSID4047670 Css NA 0.4066 mg/L PBTK NA 95% Human Human -DTXSID4047670 Clint NA 8.695 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047670 Fup NA 0.8731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047670 Vd NA 1.189 L/kg 1compartment NA NA Rat Human +DTXSID4047620 TK.Half.Life NA 2.515 hours 1compartment NA NA Rat Human +DTXSID4047620 Css NA 0.01709 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047620 Css NA 0.1369 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047620 Css NA 0.01363 mg/L PBTK NA 50% Rat Human +DTXSID4047620 Css NA 0.08733 mg/L PBTK NA 95% Rat Human +DTXSID4047622 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047622 Fup 0.0133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047622 Vd NA 26.27 L/kg 1compartment NA NA Human Human +DTXSID4047622 Days.Css NA 185 Days PBTK NA NA Human Human +DTXSID4047622 TK.Half.Life NA 779.2 hours 1compartment NA NA Human Human +DTXSID4047622 Css NA 0.8608 mg/L 3compartmentss NA 50% Human Human +DTXSID4047622 Css NA 5.386 mg/L 3compartmentss NA 95% Human Human +DTXSID4047622 Css NA 2.371 mg/L PBTK NA 50% Human Human +DTXSID4047622 Css NA 14.08 mg/L PBTK NA 95% Human Human +DTXSID4047622 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047622 Fup 0.0133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047622 Vd NA 21.58 L/kg 1compartment NA NA Rat Human +DTXSID4047622 Days.Css NA 113 Days PBTK NA NA Rat Human +DTXSID4047622 TK.Half.Life NA 111.5 hours 1compartment NA NA Rat Human +DTXSID4047622 Css NA 0.1031 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047622 Css NA 0.4997 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047622 Css NA 0.3099 mg/L PBTK NA 50% Rat Human +DTXSID4047622 Css NA 1.603 mg/L PBTK NA 95% Rat Human +DTXSID4047670 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047670 Fup 0.542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047670 Vd NA 1.047 L/kg 1compartment NA NA Human Human +DTXSID4047670 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4047670 TK.Half.Life NA 13.23 hours 1compartment NA NA Human Human +DTXSID4047670 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human +DTXSID4047670 Css NA 7.003 mg/L 3compartmentss NA 95% Human Human +DTXSID4047670 Css NA 0.9398 mg/L PBTK NA 50% Human Human +DTXSID4047670 Css NA 4.532 mg/L PBTK NA 95% Human Human +DTXSID4047670 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047670 Fup 0.542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047670 Vd NA 0.9562 L/kg 1compartment NA NA Rat Human DTXSID4047670 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047670 TK.Half.Life NA 0.5874 hours 1compartment NA NA Rat Human -DTXSID4047670 Css NA 0.02888 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047670 Css NA 0.2185 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047670 Css NA 0.0259 mg/L PBTK NA 50% Rat Human -DTXSID4047670 Css NA 0.1467 mg/L PBTK NA 95% Rat Human -DTXSID4047672 Clint NA 78.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047672 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047672 Vd NA 2.709 L/kg 1compartment NA NA Human Human -DTXSID4047672 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4047672 TK.Half.Life NA 20.85 hours 1compartment NA NA Human Human -DTXSID4047672 Css NA 1.002 mg/L 3compartmentss NA 50% Human Human -DTXSID4047672 Css NA 6.889 mg/L 3compartmentss NA 95% Human Human -DTXSID4047672 Css NA 0.6676 mg/L PBTK NA 50% Human Human -DTXSID4047672 Css NA 4.33 mg/L PBTK NA 95% Human Human -DTXSID4047672 Clint NA 78.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047672 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047672 Vd NA 2.02 L/kg 1compartment NA NA Rat Human -DTXSID4047672 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4047672 TK.Half.Life NA 4.483 hours 1compartment NA NA Rat Human -DTXSID4047672 Css NA 0.5694 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047672 Css NA 3.194 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047672 Css NA 0.3599 mg/L PBTK NA 50% Rat Human -DTXSID4047672 Css NA 1.957 mg/L PBTK NA 95% Rat Human -DTXSID4047674 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047674 Fup NA 0.7677 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047674 Vd NA 0.8116 L/kg 1compartment NA NA Human Human +DTXSID4047670 TK.Half.Life NA 3.945 hours 1compartment NA NA Rat Human +DTXSID4047670 Css NA 0.02102 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047670 Css NA 0.1711 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047670 Css NA 0.01707 mg/L PBTK NA 50% Rat Human +DTXSID4047670 Css NA 0.1124 mg/L PBTK NA 95% Rat Human +DTXSID4047672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047672 Fup 0.0163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047672 Vd NA 1.542 L/kg 1compartment NA NA Human Human +DTXSID4047672 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4047672 TK.Half.Life NA 16.19 hours 1compartment NA NA Human Human +DTXSID4047672 Css NA 1.664 mg/L 3compartmentss NA 50% Human Human +DTXSID4047672 Css NA 15.35 mg/L 3compartmentss NA 95% Human Human +DTXSID4047672 Css NA 1.044 mg/L PBTK NA 50% Human Human +DTXSID4047672 Css NA 9.172 mg/L PBTK NA 95% Human Human +DTXSID4047672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047672 Fup 0.0163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047672 Vd NA 1.14 L/kg 1compartment NA NA Rat Human +DTXSID4047672 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4047672 TK.Half.Life NA 6.15 hours 1compartment NA NA Rat Human +DTXSID4047672 Css NA 0.2191 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047672 Css NA 1.544 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047672 Css NA 0.133 mg/L PBTK NA 50% Rat Human +DTXSID4047672 Css NA 0.9037 mg/L PBTK NA 95% Rat Human +DTXSID4047674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047674 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047674 Vd NA 0.8909 L/kg 1compartment NA NA Human Human DTXSID4047674 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047674 TK.Half.Life NA 6.911 hours 1compartment NA NA Human Human -DTXSID4047674 Css NA 1.011 mg/L 3compartmentss NA 50% Human Human -DTXSID4047674 Css NA 6.269 mg/L 3compartmentss NA 95% Human Human -DTXSID4047674 Css NA 0.8378 mg/L PBTK NA 50% Human Human -DTXSID4047674 Css NA 4.022 mg/L PBTK NA 95% Human Human -DTXSID4047674 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047674 Fup NA 0.7677 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047674 Vd NA 0.8064 L/kg 1compartment NA NA Rat Human +DTXSID4047674 TK.Half.Life NA 0.7219 hours 1compartment NA NA Human Human +DTXSID4047674 Css NA 0.02816 mg/L 3compartmentss NA 50% Human Human +DTXSID4047674 Css NA 0.2958 mg/L 3compartmentss NA 95% Human Human +DTXSID4047674 Css NA 0.02352 mg/L PBTK NA 50% Human Human +DTXSID4047674 Css NA 0.2109 mg/L PBTK NA 95% Human Human +DTXSID4047674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047674 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047674 Vd NA 0.8765 L/kg 1compartment NA NA Rat Human DTXSID4047674 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047674 TK.Half.Life NA 2.321 hours 1compartment NA NA Rat Human -DTXSID4047674 Css NA 0.2629 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047674 Css NA 1.608 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047674 Css NA 0.2102 mg/L PBTK NA 50% Rat Human -DTXSID4047674 Css NA 0.9598 mg/L PBTK NA 95% Rat Human -DTXSID4047678 Clint NA 2.311 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047678 Fup NA 0.8381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047678 Vd NA 1.482 L/kg 1compartment NA NA Human Human +DTXSID4047674 TK.Half.Life NA 0.3469 hours 1compartment NA NA Rat Human +DTXSID4047674 Css NA 0.003284 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047674 Css NA 0.03056 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047674 Css NA 0.002793 mg/L PBTK NA 50% Rat Human +DTXSID4047674 Css NA 0.02104 mg/L PBTK NA 95% Rat Human +DTXSID4047678 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047678 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047678 Vd NA 1.097 L/kg 1compartment NA NA Human Human DTXSID4047678 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047678 TK.Half.Life NA 3.129 hours 1compartment NA NA Human Human -DTXSID4047678 Css NA 0.1928 mg/L 3compartmentss NA 50% Human Human -DTXSID4047678 Css NA 1.38 mg/L 3compartmentss NA 95% Human Human -DTXSID4047678 Css NA 0.1772 mg/L PBTK NA 50% Human Human -DTXSID4047678 Css NA 0.9852 mg/L PBTK NA 95% Human Human -DTXSID4047678 Clint NA 2.311 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047678 Fup NA 0.8381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047678 Vd NA 1.333 L/kg 1compartment NA NA Rat Human +DTXSID4047678 TK.Half.Life NA 1.083 hours 1compartment NA NA Human Human +DTXSID4047678 Css NA 0.03896 mg/L 3compartmentss NA 50% Human Human +DTXSID4047678 Css NA 0.3513 mg/L 3compartmentss NA 95% Human Human +DTXSID4047678 Css NA 0.03167 mg/L PBTK NA 50% Human Human +DTXSID4047678 Css NA 0.2467 mg/L PBTK NA 95% Human Human +DTXSID4047678 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047678 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047678 Vd NA 0.9812 L/kg 1compartment NA NA Rat Human DTXSID4047678 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047678 TK.Half.Life NA 1.377 hours 1compartment NA NA Rat Human -DTXSID4047678 Css NA 0.08402 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047678 Css NA 0.5728 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047678 Css NA 0.07585 mg/L PBTK NA 50% Rat Human -DTXSID4047678 Css NA 0.3622 mg/L PBTK NA 95% Rat Human -DTXSID4047703 Clint NA 4.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047703 Fup NA 0.545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047703 Vd NA 1.829 L/kg 1compartment NA NA Human Human +DTXSID4047678 TK.Half.Life NA 0.482 hours 1compartment NA NA Rat Human +DTXSID4047678 Css NA 0.004711 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047678 Css NA 0.03498 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047678 Css NA 0.003868 mg/L PBTK NA 50% Rat Human +DTXSID4047678 Css NA 0.02373 mg/L PBTK NA 95% Rat Human +DTXSID4047703 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047703 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047703 Vd NA 1.637 L/kg 1compartment NA NA Human Human DTXSID4047703 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047703 TK.Half.Life NA 4.393 hours 1compartment NA NA Human Human -DTXSID4047703 Css NA 0.2047 mg/L 3compartmentss NA 50% Human Human -DTXSID4047703 Css NA 1.475 mg/L 3compartmentss NA 95% Human Human -DTXSID4047703 Css NA 0.1741 mg/L PBTK NA 50% Human Human -DTXSID4047703 Css NA 1.019 mg/L PBTK NA 95% Human Human -DTXSID4047703 Clint NA 4.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047703 Fup NA 0.545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047703 Vd NA 1.508 L/kg 1compartment NA NA Rat Human +DTXSID4047703 TK.Half.Life NA 2.182 hours 1compartment NA NA Human Human +DTXSID4047703 Css NA 0.07052 mg/L 3compartmentss NA 50% Human Human +DTXSID4047703 Css NA 0.5472 mg/L 3compartmentss NA 95% Human Human +DTXSID4047703 Css NA 0.05442 mg/L PBTK NA 50% Human Human +DTXSID4047703 Css NA 0.3789 mg/L PBTK NA 95% Human Human +DTXSID4047703 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047703 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047703 Vd NA 1.319 L/kg 1compartment NA NA Rat Human DTXSID4047703 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047703 TK.Half.Life NA 1.666 hours 1compartment NA NA Rat Human -DTXSID4047703 Css NA 0.09957 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047703 Css NA 0.5906 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047703 Css NA 0.08207 mg/L PBTK NA 50% Rat Human -DTXSID4047703 Css NA 0.3772 mg/L PBTK NA 95% Rat Human -DTXSID4047705 Clint NA 20.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047705 Fup NA 0.0607 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047705 Vd NA 1.899 L/kg 1compartment NA NA Human Human -DTXSID4047705 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047705 TK.Half.Life NA 9.077 hours 1compartment NA NA Human Human -DTXSID4047705 Css NA 0.635 mg/L 3compartmentss NA 50% Human Human -DTXSID4047705 Css NA 4.17 mg/L 3compartmentss NA 95% Human Human -DTXSID4047705 Css NA 0.417 mg/L PBTK NA 50% Human Human -DTXSID4047705 Css NA 2.622 mg/L PBTK NA 95% Human Human -DTXSID4047705 Clint NA 20.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047705 Fup NA 0.0607 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047705 Vd NA 1.428 L/kg 1compartment NA NA Rat Human -DTXSID4047705 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047705 TK.Half.Life NA 3.088 hours 1compartment NA NA Rat Human -DTXSID4047705 Css NA 0.3494 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047705 Css NA 1.948 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047705 Css NA 0.2168 mg/L PBTK NA 50% Rat Human -DTXSID4047705 Css NA 1.145 mg/L PBTK NA 95% Rat Human -DTXSID4047707 Clint NA 2.297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047707 Fup NA 0.6671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047707 Vd NA 1.536 L/kg 1compartment NA NA Human Human -DTXSID4047707 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047707 TK.Half.Life NA 4.143 hours 1compartment NA NA Human Human -DTXSID4047707 Css NA 0.2458 mg/L 3compartmentss NA 50% Human Human -DTXSID4047707 Css NA 1.934 mg/L 3compartmentss NA 95% Human Human -DTXSID4047707 Css NA 0.2182 mg/L PBTK NA 50% Human Human -DTXSID4047707 Css NA 1.31 mg/L PBTK NA 95% Human Human -DTXSID4047707 Clint NA 2.297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047707 Fup NA 0.6671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047707 Vd NA 1.333 L/kg 1compartment NA NA Rat Human -DTXSID4047707 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047707 TK.Half.Life NA 1.722 hours 1compartment NA NA Rat Human -DTXSID4047707 Css NA 0.1078 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047707 Css NA 0.7263 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047707 Css NA 0.0935 mg/L PBTK NA 50% Rat Human -DTXSID4047707 Css NA 0.4585 mg/L PBTK NA 95% Rat Human -DTXSID4047709 Clint NA 0.0103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047709 Fup NA 0.8604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047709 Vd NA 0.613 L/kg 1compartment NA NA Human Human -DTXSID4047709 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047709 TK.Half.Life NA 4.533 hours 1compartment NA NA Human Human -DTXSID4047709 Css NA 0.9978 mg/L 3compartmentss NA 50% Human Human -DTXSID4047709 Css NA 5.398 mg/L 3compartmentss NA 95% Human Human -DTXSID4047709 Css NA 0.7774 mg/L PBTK NA 50% Human Human -DTXSID4047709 Css NA 3.459 mg/L PBTK NA 95% Human Human -DTXSID4047709 Clint NA 0.0103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047709 Fup NA 0.8604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047709 Vd NA 0.6392 L/kg 1compartment NA NA Rat Human -DTXSID4047709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047709 TK.Half.Life NA 1.625 hours 1compartment NA NA Rat Human -DTXSID4047709 Css NA 0.2546 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047709 Css NA 1.431 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047709 Css NA 0.1924 mg/L PBTK NA 50% Rat Human -DTXSID4047709 Css NA 0.843 mg/L PBTK NA 95% Rat Human -DTXSID4047838 Clint NA 7.905 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047838 Fup NA 0.4323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047838 Vd NA 3.189 L/kg 1compartment NA NA Human Human -DTXSID4047838 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4047838 TK.Half.Life NA 14.42 hours 1compartment NA NA Human Human -DTXSID4047838 Css NA 0.4286 mg/L 3compartmentss NA 50% Human Human -DTXSID4047838 Css NA 2.36 mg/L 3compartmentss NA 95% Human Human -DTXSID4047838 Css NA 0.3464 mg/L PBTK NA 50% Human Human -DTXSID4047838 Css NA 1.781 mg/L PBTK NA 95% Human Human -DTXSID4047838 Clint NA 7.905 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047838 Fup NA 0.4323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047838 Vd NA 2.561 L/kg 1compartment NA NA Rat Human +DTXSID4047703 TK.Half.Life NA 0.8411 hours 1compartment NA NA Rat Human +DTXSID4047703 Css NA 0.009025 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047703 Css NA 0.04942 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047703 Css NA 0.006955 mg/L PBTK NA 50% Rat Human +DTXSID4047703 Css NA 0.03449 mg/L PBTK NA 95% Rat Human +DTXSID4047705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047705 Fup 0.0366 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047705 Vd NA 2.572 L/kg 1compartment NA NA Human Human +DTXSID4047705 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4047705 TK.Half.Life NA 23.61 hours 1compartment NA NA Human Human +DTXSID4047705 Css NA 1.198 mg/L 3compartmentss NA 50% Human Human +DTXSID4047705 Css NA 8.529 mg/L 3compartmentss NA 95% Human Human +DTXSID4047705 Css NA 0.7993 mg/L PBTK NA 50% Human Human +DTXSID4047705 Css NA 5.467 mg/L PBTK NA 95% Human Human +DTXSID4047705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047705 Fup 0.0366 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047705 Vd NA 1.925 L/kg 1compartment NA NA Rat Human +DTXSID4047705 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4047705 TK.Half.Life NA 5.64 hours 1compartment NA NA Rat Human +DTXSID4047705 Css NA 0.1563 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047705 Css NA 0.8773 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047705 Css NA 0.103 mg/L PBTK NA 50% Rat Human +DTXSID4047705 Css NA 0.5546 mg/L PBTK NA 95% Rat Human +DTXSID4047838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047838 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047838 Vd NA 3.033 L/kg 1compartment NA NA Human Human +DTXSID4047838 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047838 TK.Half.Life NA 7.859 hours 1compartment NA NA Human Human +DTXSID4047838 Css NA 0.2075 mg/L 3compartmentss NA 50% Human Human +DTXSID4047838 Css NA 1.384 mg/L 3compartmentss NA 95% Human Human +DTXSID4047838 Css NA 0.1626 mg/L PBTK NA 50% Human Human +DTXSID4047838 Css NA 0.9963 mg/L PBTK NA 95% Human Human +DTXSID4047838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047838 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047838 Vd NA 2.41 L/kg 1compartment NA NA Rat Human DTXSID4047838 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047838 TK.Half.Life NA 3.257 hours 1compartment NA NA Rat Human -DTXSID4047838 Css NA 0.221 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047838 Css NA 0.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047838 Css NA 0.1745 mg/L PBTK NA 50% Rat Human -DTXSID4047838 Css NA 0.6578 mg/L PBTK NA 95% Rat Human -DTXSID4047880 Clint NA 20.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047880 Fup NA 0.0768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047880 Vd NA 1.91 L/kg 1compartment NA NA Human Human +DTXSID4047838 TK.Half.Life NA 2.016 hours 1compartment NA NA Rat Human +DTXSID4047838 Css NA 0.026 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047838 Css NA 0.13 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047838 Css NA 0.0203 mg/L PBTK NA 50% Rat Human +DTXSID4047838 Css NA 0.09434 mg/L PBTK NA 95% Rat Human +DTXSID4047880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047880 Fup 0.0362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047880 Vd NA 1.297 L/kg 1compartment NA NA Human Human DTXSID4047880 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047880 TK.Half.Life NA 7.574 hours 1compartment NA NA Human Human -DTXSID4047880 Css NA 0.4885 mg/L 3compartmentss NA 50% Human Human -DTXSID4047880 Css NA 3.476 mg/L 3compartmentss NA 95% Human Human -DTXSID4047880 Css NA 0.3239 mg/L PBTK NA 50% Human Human -DTXSID4047880 Css NA 2.174 mg/L PBTK NA 95% Human Human -DTXSID4047880 Clint NA 20.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047880 Fup NA 0.0768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047880 Vd NA 1.441 L/kg 1compartment NA NA Rat Human +DTXSID4047880 TK.Half.Life NA 7.473 hours 1compartment NA NA Human Human +DTXSID4047880 Css NA 0.8603 mg/L 3compartmentss NA 50% Human Human +DTXSID4047880 Css NA 6.647 mg/L 3compartmentss NA 95% Human Human +DTXSID4047880 Css NA 0.5372 mg/L PBTK NA 50% Human Human +DTXSID4047880 Css NA 4.066 mg/L PBTK NA 95% Human Human +DTXSID4047880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047880 Fup 0.0362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047880 Vd NA 0.9718 L/kg 1compartment NA NA Rat Human DTXSID4047880 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047880 TK.Half.Life NA 2.579 hours 1compartment NA NA Rat Human -DTXSID4047880 Css NA 0.2702 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047880 Css NA 1.476 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047880 Css NA 0.1707 mg/L PBTK NA 50% Rat Human -DTXSID4047880 Css NA 0.8893 mg/L PBTK NA 95% Rat Human +DTXSID4047880 TK.Half.Life NA 3.044 hours 1compartment NA NA Rat Human +DTXSID4047880 Css NA 0.1123 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047880 Css NA 0.6891 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047880 Css NA 0.06786 mg/L PBTK NA 50% Rat Human +DTXSID4047880 Css NA 0.4023 mg/L PBTK NA 95% Rat Human DTXSID4047882 Clint 865 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4047882 Fup 0.045 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4047882 Vd NA 1.716 L/kg 1compartment NA NA Human Human +DTXSID4047882 Vd NA 1.746 L/kg 1compartment NA NA Human Human DTXSID4047882 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047882 TK.Half.Life NA 1.691 hours 1compartment NA NA Human Human -DTXSID4047882 Css NA 0.01711 mg/L 3compartmentss NA 50% Human Human -DTXSID4047882 Css NA 0.1327 mg/L 3compartmentss NA 95% Human Human -DTXSID4047882 Css NA 0.0111 mg/L PBTK NA 50% Human Human -DTXSID4047882 Css NA 0.08253 mg/L PBTK NA 95% Human Human +DTXSID4047882 TK.Half.Life NA 1.72 hours 1compartment NA NA Human Human +DTXSID4047882 Css NA 0.0147 mg/L 3compartmentss NA 50% Human Human +DTXSID4047882 Css NA 0.1263 mg/L 3compartmentss NA 95% Human Human +DTXSID4047882 Css NA 0.009571 mg/L PBTK NA 50% Human Human +DTXSID4047882 Css NA 0.07991 mg/L PBTK NA 95% Human Human DTXSID4047882 Clint 865 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4047882 Fup 0.045 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4047882 Vd NA 1.285 L/kg 1compartment NA NA Rat Human +DTXSID4047882 Vd NA 1.307 L/kg 1compartment NA NA Rat Human DTXSID4047882 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047882 TK.Half.Life NA 0.5631 hours 1compartment NA NA Rat Human -DTXSID4047882 Css NA 0.009781 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047882 Css NA 0.06266 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047882 Css NA 0.006015 mg/L PBTK NA 50% Rat Human -DTXSID4047882 Css NA 0.03764 mg/L PBTK NA 95% Rat Human -DTXSID4047886 Clint NA 74.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047886 Fup NA 0.065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047886 Vd NA 1.266 L/kg 1compartment NA NA Human Human +DTXSID4047882 TK.Half.Life NA 0.5719 hours 1compartment NA NA Rat Human +DTXSID4047882 Css NA 0.002016 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047882 Css NA 0.01386 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047882 Css NA 0.001281 mg/L PBTK NA 50% Rat Human +DTXSID4047882 Css NA 0.00845 mg/L PBTK NA 95% Rat Human +DTXSID4047886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047886 Fup 0.0738 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047886 Vd NA 1.532 L/kg 1compartment NA NA Human Human DTXSID4047886 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047886 TK.Half.Life NA 2.176 hours 1compartment NA NA Human Human -DTXSID4047886 Css NA 0.1396 mg/L 3compartmentss NA 50% Human Human -DTXSID4047886 Css NA 1.059 mg/L 3compartmentss NA 95% Human Human -DTXSID4047886 Css NA 0.0899 mg/L PBTK NA 50% Human Human -DTXSID4047886 Css NA 0.6587 mg/L PBTK NA 95% Human Human -DTXSID4047886 Clint NA 74.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047886 Fup NA 0.065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047886 Vd NA 0.9628 L/kg 1compartment NA NA Rat Human +DTXSID4047886 TK.Half.Life NA 5.454 hours 1compartment NA NA Human Human +DTXSID4047886 Css NA 0.4252 mg/L 3compartmentss NA 50% Human Human +DTXSID4047886 Css NA 3.104 mg/L 3compartmentss NA 95% Human Human +DTXSID4047886 Css NA 0.278 mg/L PBTK NA 50% Human Human +DTXSID4047886 Css NA 1.944 mg/L PBTK NA 95% Human Human +DTXSID4047886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047886 Fup 0.0738 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047886 Vd NA 1.161 L/kg 1compartment NA NA Rat Human DTXSID4047886 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047886 TK.Half.Life NA 0.8398 hours 1compartment NA NA Rat Human -DTXSID4047886 Css NA 0.07966 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047886 Css NA 0.4884 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047886 Css NA 0.04812 mg/L PBTK NA 50% Rat Human -DTXSID4047886 Css NA 0.2821 mg/L PBTK NA 95% Rat Human -DTXSID4047888 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047888 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047888 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID4047888 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4047888 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID4047888 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID4047888 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID4047888 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID4047888 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID4047888 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047888 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047888 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID4047888 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047888 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID4047888 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047888 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047888 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID4047888 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID4047913 Clint NA 82.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047913 Fup NA 0.8462 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047913 Vd NA 0.9013 L/kg 1compartment NA NA Human Human -DTXSID4047913 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047913 TK.Half.Life NA 0.5536 hours 1compartment NA NA Human Human -DTXSID4047913 Css NA 0.007322 mg/L 3compartmentss NA 50% Human Human -DTXSID4047913 Css NA 0.08167 mg/L 3compartmentss NA 95% Human Human -DTXSID4047913 Css NA 0.006143 mg/L PBTK NA 50% Human Human -DTXSID4047913 Css NA 0.05764 mg/L PBTK NA 95% Human Human -DTXSID4047913 Clint NA 82.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047913 Fup NA 0.8462 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047913 Vd NA 0.9035 L/kg 1compartment NA NA Rat Human -DTXSID4047913 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047913 TK.Half.Life NA 0.2487 hours 1compartment NA NA Rat Human -DTXSID4047913 Css NA 0.003762 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047913 Css NA 0.03696 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047913 Css NA 0.003156 mg/L PBTK NA 50% Rat Human -DTXSID4047913 Css NA 0.02569 mg/L PBTK NA 95% Rat Human -DTXSID4047917 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047917 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047917 Vd NA 1.169 L/kg 1compartment NA NA Human Human -DTXSID4047917 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047917 TK.Half.Life NA 0.8031 hours 1compartment NA NA Human Human -DTXSID4047917 Css NA 0.00848 mg/L 3compartmentss NA 50% Human Human -DTXSID4047917 Css NA 0.09565 mg/L 3compartmentss NA 95% Human Human -DTXSID4047917 Css NA 0.007025 mg/L PBTK NA 50% Human Human -DTXSID4047917 Css NA 0.06697 mg/L PBTK NA 95% Human Human -DTXSID4047917 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047917 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047917 Vd NA 1.051 L/kg 1compartment NA NA Rat Human -DTXSID4047917 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047917 TK.Half.Life NA 0.3251 hours 1compartment NA NA Rat Human -DTXSID4047917 Css NA 0.004516 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047917 Css NA 0.04394 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047917 Css NA 0.003684 mg/L PBTK NA 50% Rat Human -DTXSID4047917 Css NA 0.0294 mg/L PBTK NA 95% Rat Human -DTXSID4047919 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047919 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047919 Vd NA 3.157 L/kg 1compartment NA NA Human Human -DTXSID4047919 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047919 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human -DTXSID4047919 Css NA 0.3557 mg/L 3compartmentss NA 50% Human Human -DTXSID4047919 Css NA 2.326 mg/L 3compartmentss NA 95% Human Human -DTXSID4047919 Css NA 0.2508 mg/L PBTK NA 50% Human Human -DTXSID4047919 Css NA 1.568 mg/L PBTK NA 95% Human Human -DTXSID4047919 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047919 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047919 Vd NA 2.375 L/kg 1compartment NA NA Rat Human -DTXSID4047919 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047919 TK.Half.Life NA 2.005 hours 1compartment NA NA Rat Human -DTXSID4047919 Css NA 0.199 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047919 Css NA 1.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047919 Css NA 0.1344 mg/L PBTK NA 50% Rat Human -DTXSID4047919 Css NA 0.7061 mg/L PBTK NA 95% Rat Human -DTXSID4047961 Clint NA 24.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047961 Fup NA 0.0245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047961 Vd NA 1.306 L/kg 1compartment NA NA Human Human -DTXSID4047961 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4047961 TK.Half.Life NA 8.981 hours 1compartment NA NA Human Human -DTXSID4047961 Css NA 1.071 mg/L 3compartmentss NA 50% Human Human -DTXSID4047961 Css NA 9.36 mg/L 3compartmentss NA 95% Human Human -DTXSID4047961 Css NA 0.668 mg/L PBTK NA 50% Human Human -DTXSID4047961 Css NA 5.738 mg/L PBTK NA 95% Human Human -DTXSID4047961 Clint NA 24.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047961 Fup NA 0.0245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047961 Vd NA 0.9704 L/kg 1compartment NA NA Rat Human -DTXSID4047961 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047961 TK.Half.Life NA 3.639 hours 1compartment NA NA Rat Human -DTXSID4047961 Css NA 0.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047961 Css NA 4.459 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047961 Css NA 0.3491 mg/L PBTK NA 50% Rat Human -DTXSID4047961 Css NA 2.474 mg/L PBTK NA 95% Rat Human -DTXSID4047963 Clint NA 2.631 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047963 Fup NA 0.0225 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047963 Vd NA 2.419 L/kg 1compartment NA NA Human Human -DTXSID4047963 Days.Css NA 39 Days PBTK NA NA Human Human -DTXSID4047963 TK.Half.Life NA 190.7 hours 1compartment NA NA Human Human -DTXSID4047963 Css NA 11.68 mg/L 3compartmentss NA 50% Human Human -DTXSID4047963 Css NA 68.67 mg/L 3compartmentss NA 95% Human Human -DTXSID4047963 Css NA 7.768 mg/L PBTK NA 50% Human Human -DTXSID4047963 Css NA 43.21 mg/L PBTK NA 95% Human Human -DTXSID4047963 Clint NA 2.631 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047963 Fup NA 0.0225 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047963 Vd NA 1.804 L/kg 1compartment NA NA Rat Human -DTXSID4047963 Days.Css NA 19 Days PBTK NA NA Rat Human -DTXSID4047963 TK.Half.Life NA 45.1 hours 1compartment NA NA Rat Human -DTXSID4047963 Css NA 6.058 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047963 Css NA 26.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047963 Css NA 3.802 mg/L PBTK NA 50% Rat Human -DTXSID4047963 Css NA 15.41 mg/L PBTK NA 95% Rat Human -DTXSID4047967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047967 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047967 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID4047967 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4047967 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID4047967 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID4047967 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID4047967 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID4047967 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID4047967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047967 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047967 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID4047967 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047967 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID4047967 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047967 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047967 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID4047967 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID4047969 Clint NA 0.3335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047969 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4047969 Vd NA 0.3994 L/kg 1compartment NA NA Human Human -DTXSID4047969 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4047969 TK.Half.Life NA 13.58 hours 1compartment NA NA Human Human -DTXSID4047969 Css NA 4.849 mg/L 3compartmentss NA 50% Human Human -DTXSID4047969 Css NA 24.16 mg/L 3compartmentss NA 95% Human Human -DTXSID4047969 Css NA 3.151 mg/L PBTK NA 50% Human Human -DTXSID4047969 Css NA 14.45 mg/L PBTK NA 95% Human Human -DTXSID4047969 Clint NA 0.3335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047969 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4047969 Vd NA 0.3942 L/kg 1compartment NA NA Rat Human +DTXSID4047886 TK.Half.Life NA 2.088 hours 1compartment NA NA Rat Human +DTXSID4047886 Css NA 0.0549 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047886 Css NA 0.3269 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047886 Css NA 0.03504 mg/L PBTK NA 50% Rat Human +DTXSID4047886 Css NA 0.1987 mg/L PBTK NA 95% Rat Human +DTXSID4047963 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047963 Fup 0.0089 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047963 Vd NA 2.355 L/kg 1compartment NA NA Human Human +DTXSID4047963 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID4047963 TK.Half.Life NA 42.11 hours 1compartment NA NA Human Human +DTXSID4047963 Css NA 2.624 mg/L 3compartmentss NA 50% Human Human +DTXSID4047963 Css NA 19.44 mg/L 3compartmentss NA 95% Human Human +DTXSID4047963 Css NA 1.711 mg/L PBTK NA 50% Human Human +DTXSID4047963 Css NA 12.15 mg/L PBTK NA 95% Human Human +DTXSID4047963 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047963 Fup 0.0089 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047963 Vd NA 1.751 L/kg 1compartment NA NA Rat Human +DTXSID4047963 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4047963 TK.Half.Life NA 11.26 hours 1compartment NA NA Rat Human +DTXSID4047963 Css NA 0.3435 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047963 Css NA 2.229 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047963 Css NA 0.2187 mg/L PBTK NA 50% Rat Human +DTXSID4047963 Css NA 1.367 mg/L PBTK NA 95% Rat Human +DTXSID4047969 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047969 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4047969 Vd NA 0.3502 L/kg 1compartment NA NA Human Human +DTXSID4047969 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4047969 TK.Half.Life NA 8.614 hours 1compartment NA NA Human Human +DTXSID4047969 Css NA 2.912 mg/L 3compartmentss NA 50% Human Human +DTXSID4047969 Css NA 11.1 mg/L 3compartmentss NA 95% Human Human +DTXSID4047969 Css NA 1.956 mg/L PBTK NA 50% Human Human +DTXSID4047969 Css NA 6.779 mg/L PBTK NA 95% Human Human +DTXSID4047969 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047969 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4047969 Vd NA 0.3627 L/kg 1compartment NA NA Rat Human DTXSID4047969 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4047969 TK.Half.Life NA 5.581 hours 1compartment NA NA Rat Human -DTXSID4047969 Css NA 1.724 mg/L 3compartmentss NA 50% Rat Human -DTXSID4047969 Css NA 7.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID4047969 Css NA 1.055 mg/L PBTK NA 50% Rat Human -DTXSID4047969 Css NA 3.957 mg/L PBTK NA 95% Rat Human +DTXSID4047969 TK.Half.Life NA 3.04 hours 1compartment NA NA Rat Human +DTXSID4047969 Css NA 0.1896 mg/L 3compartmentss NA 50% Rat Human +DTXSID4047969 Css NA 0.5883 mg/L 3compartmentss NA 95% Rat Human +DTXSID4047969 Css NA 0.1237 mg/L PBTK NA 50% Rat Human +DTXSID4047969 Css NA 0.3486 mg/L PBTK NA 95% Rat Human DTXSID4048191 Clint 8.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4048191 Fup 0.00874 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4048191 Vd NA 2.926 L/kg 1compartment NA NA Human Human -DTXSID4048191 Days.Css NA 35 Days PBTK NA NA Human Human -DTXSID4048191 TK.Half.Life NA 177.6 hours 1compartment NA NA Human Human -DTXSID4048191 Css NA 7.521 mg/L 3compartmentss NA 50% Human Human -DTXSID4048191 Css NA 46.32 mg/L 3compartmentss NA 95% Human Human -DTXSID4048191 Css NA 5.175 mg/L PBTK NA 50% Human Human -DTXSID4048191 Css NA 30.9 mg/L PBTK NA 95% Human Human +DTXSID4048191 Vd NA 2.295 L/kg 1compartment NA NA Human Human +DTXSID4048191 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID4048191 TK.Half.Life NA 103.2 hours 1compartment NA NA Human Human +DTXSID4048191 Css NA 5.652 mg/L 3compartmentss NA 50% Human Human +DTXSID4048191 Css NA 34.46 mg/L 3compartmentss NA 95% Human Human +DTXSID4048191 Css NA 3.726 mg/L PBTK NA 50% Human Human +DTXSID4048191 Css NA 21.79 mg/L PBTK NA 95% Human Human DTXSID4048191 Clint 8.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4048191 Fup 0.00874 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4048191 Vd NA 2.189 L/kg 1compartment NA NA Rat Human -DTXSID4048191 Days.Css NA 19 Days PBTK NA NA Rat Human -DTXSID4048191 TK.Half.Life NA 29.63 hours 1compartment NA NA Rat Human -DTXSID4048191 Css NA 4.196 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048191 Css NA 21.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048191 Css NA 2.752 mg/L PBTK NA 50% Rat Human -DTXSID4048191 Css NA 13.88 mg/L PBTK NA 95% Rat Human -DTXSID4048193 Clint NA 217.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048193 Fup NA 0.0167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048193 Vd NA 107.5 L/kg 1compartment NA NA Human Human -DTXSID4048193 Days.Css NA 64 Days PBTK NA NA Human Human -DTXSID4048193 TK.Half.Life NA 319.3 hours 1compartment NA NA Human Human -DTXSID4048193 Css NA 0.01863 mg/L 3compartmentss NA 50% Human Human -DTXSID4048193 Css NA 0.1183 mg/L 3compartmentss NA 95% Human Human -DTXSID4048193 Css NA 0.244 mg/L PBTK NA 50% Human Human -DTXSID4048193 Css NA 1.381 mg/L PBTK NA 95% Human Human -DTXSID4048193 Clint NA 217.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048193 Fup NA 0.0167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048193 Vd NA 93.15 L/kg 1compartment NA NA Rat Human -DTXSID4048193 Days.Css NA 44 Days PBTK NA NA Rat Human -DTXSID4048193 TK.Half.Life NA 48.51 hours 1compartment NA NA Rat Human -DTXSID4048193 Css NA 0.009314 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048193 Css NA 0.04031 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048193 Css NA 0.1316 mg/L PBTK NA 50% Rat Human -DTXSID4048193 Css NA 0.5525 mg/L PBTK NA 95% Rat Human +DTXSID4048191 Vd NA 1.705 L/kg 1compartment NA NA Rat Human +DTXSID4048191 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID4048191 TK.Half.Life NA 28.01 hours 1compartment NA NA Rat Human +DTXSID4048191 Css NA 0.722 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048191 Css NA 3.59 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048191 Css NA 0.4695 mg/L PBTK NA 50% Rat Human +DTXSID4048191 Css NA 2.281 mg/L PBTK NA 95% Rat Human DTXSID4048195 Clint 83.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4048195 Fup 0.00077 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4048195 Vd NA 0.3024 L/kg 1compartment NA NA Human Human +DTXSID4048195 Vd NA 0.4055 L/kg 1compartment NA NA Human Human DTXSID4048195 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4048195 TK.Half.Life NA 13.11 hours 1compartment NA NA Human Human -DTXSID4048195 Css NA 8.112 mg/L 3compartmentss NA 50% Human Human -DTXSID4048195 Css NA 110 mg/L 3compartmentss NA 95% Human Human -DTXSID4048195 Css NA 4.724 mg/L PBTK NA 50% Human Human -DTXSID4048195 Css NA 63.82 mg/L PBTK NA 95% Human Human +DTXSID4048195 TK.Half.Life NA 15.04 hours 1compartment NA NA Human Human +DTXSID4048195 Css NA 6.699 mg/L 3compartmentss NA 50% Human Human +DTXSID4048195 Css NA 90.72 mg/L 3compartmentss NA 95% Human Human +DTXSID4048195 Css NA 3.896 mg/L PBTK NA 50% Human Human +DTXSID4048195 Css NA 53.89 mg/L PBTK NA 95% Human Human DTXSID4048195 Clint 83.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4048195 Fup 0.00077 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4048195 Vd NA 0.241 L/kg 1compartment NA NA Rat Human +DTXSID4048195 Vd NA 0.3082 L/kg 1compartment NA NA Rat Human DTXSID4048195 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048195 TK.Half.Life NA 7.169 hours 1compartment NA NA Rat Human -DTXSID4048195 Css NA 4.767 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048195 Css NA 51.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048195 Css NA 2.586 mg/L PBTK NA 50% Rat Human -DTXSID4048195 Css NA 27.8 mg/L PBTK NA 95% Rat Human +DTXSID4048195 TK.Half.Life NA 7.749 hours 1compartment NA NA Rat Human +DTXSID4048195 Css NA 0.9254 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048195 Css NA 9.983 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048195 Css NA 0.5208 mg/L PBTK NA 50% Rat Human +DTXSID4048195 Css NA 5.619 mg/L PBTK NA 95% Rat Human DTXSID4048199 Clint 28.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID4048199 Fup 0.165 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID4048199 Vd NA 0.6557 L/kg 1compartment NA NA Human Human +DTXSID4048199 Vd NA 0.7308 L/kg 1compartment NA NA Human Human DTXSID4048199 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048199 TK.Half.Life NA 1.06 hours 1compartment NA NA Human Human -DTXSID4048199 Css NA 0.1041 mg/L 3compartmentss NA 50% Human Human -DTXSID4048199 Css NA 0.5994 mg/L 3compartmentss NA 95% Human Human -DTXSID4048199 Css NA 0.06953 mg/L PBTK NA 50% Human Human -DTXSID4048199 Css NA 0.3965 mg/L PBTK NA 95% Human Human +DTXSID4048199 TK.Half.Life NA 1.182 hours 1compartment NA NA Human Human +DTXSID4048199 Css NA 0.09809 mg/L 3compartmentss NA 50% Human Human +DTXSID4048199 Css NA 0.613 mg/L 3compartmentss NA 95% Human Human +DTXSID4048199 Css NA 0.06572 mg/L PBTK NA 50% Human Human +DTXSID4048199 Css NA 0.4036 mg/L PBTK NA 95% Human Human DTXSID4048199 Clint 28.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID4048199 Fup 0.165 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID4048199 Vd NA 0.5739 L/kg 1compartment NA NA Rat Human +DTXSID4048199 Vd NA 0.6268 L/kg 1compartment NA NA Rat Human DTXSID4048199 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048199 TK.Half.Life NA 0.5059 hours 1compartment NA NA Rat Human -DTXSID4048199 Css NA 0.05684 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048199 Css NA 0.2606 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048199 Css NA 0.03604 mg/L PBTK NA 50% Rat Human -DTXSID4048199 Css NA 0.1611 mg/L PBTK NA 95% Rat Human +DTXSID4048199 TK.Half.Life NA 0.5497 hours 1compartment NA NA Rat Human +DTXSID4048199 Css NA 0.01253 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048199 Css NA 0.06027 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048199 Css NA 0.008343 mg/L PBTK NA 50% Rat Human +DTXSID4048199 Css NA 0.0394 mg/L PBTK NA 95% Rat Human DTXSID4048270 Clint NA 1.886 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4048270 Fup NA 0.1214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048270 Vd NA 0.3063 L/kg 1compartment NA NA Human Human +DTXSID4048270 Vd NA 0.3331 L/kg 1compartment NA NA Human Human DTXSID4048270 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048270 TK.Half.Life NA 4.077 hours 1compartment NA NA Human Human -DTXSID4048270 Css NA 2.018 mg/L 3compartmentss NA 50% Human Human -DTXSID4048270 Css NA 11.45 mg/L 3compartmentss NA 95% Human Human -DTXSID4048270 Css NA 1.263 mg/L PBTK NA 50% Human Human -DTXSID4048270 Css NA 6.846 mg/L PBTK NA 95% Human Human +DTXSID4048270 TK.Half.Life NA 4.458 hours 1compartment NA NA Human Human +DTXSID4048270 Css NA 1.717 mg/L 3compartmentss NA 50% Human Human +DTXSID4048270 Css NA 9.888 mg/L 3compartmentss NA 95% Human Human +DTXSID4048270 Css NA 1.092 mg/L PBTK NA 50% Human Human +DTXSID4048270 Css NA 5.951 mg/L PBTK NA 95% Human Human DTXSID4048270 Clint NA 1.886 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4048270 Fup NA 0.1214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048270 Vd NA 0.3062 L/kg 1compartment NA NA Rat Human +DTXSID4048270 Vd NA 0.3308 L/kg 1compartment NA NA Rat Human DTXSID4048270 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048270 TK.Half.Life NA 2.237 hours 1compartment NA NA Rat Human -DTXSID4048270 Css NA 0.9314 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048270 Css NA 4.092 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048270 Css NA 0.5484 mg/L PBTK NA 50% Rat Human -DTXSID4048270 Css NA 2.264 mg/L PBTK NA 95% Rat Human -DTXSID4048511 Clint NA 58.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048511 Fup NA 0.15 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048511 Vd NA 2.106 L/kg 1compartment NA NA Human Human +DTXSID4048270 TK.Half.Life NA 2.428 hours 1compartment NA NA Rat Human +DTXSID4048270 Css NA 0.06746 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048270 Css NA 0.4931 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048270 Css NA 0.04141 mg/L PBTK NA 50% Rat Human +DTXSID4048270 Css NA 0.2851 mg/L PBTK NA 95% Rat Human +DTXSID4048276 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048276 Fup 0.49 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4048276 Vd NA 3.604 L/kg 1compartment NA NA Human Human +DTXSID4048276 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4048276 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human +DTXSID4048276 Css NA 0.07434 mg/L 3compartmentss NA 50% Human Human +DTXSID4048276 Css NA 0.7446 mg/L 3compartmentss NA 95% Human Human +DTXSID4048276 Css NA 0.09528 mg/L PBTK NA 50% Human Human +DTXSID4048276 Css NA 0.6355 mg/L PBTK NA 95% Human Human +DTXSID4048276 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048276 Fup 0.49 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4048276 Vd NA 3.657 L/kg 1compartment NA NA Rat Human +DTXSID4048276 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4048276 TK.Half.Life NA 3.016 hours 1compartment NA NA Rat Human +DTXSID4048276 Css NA 0.008342 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048276 Css NA 0.06636 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048276 Css NA 0.01124 mg/L PBTK NA 50% Rat Human +DTXSID4048276 Css NA 0.05436 mg/L PBTK NA 95% Rat Human +DTXSID4048436 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048436 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4048436 Vd NA 1.597 L/kg 1compartment NA NA Human Human +DTXSID4048436 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4048436 TK.Half.Life NA 6.736 hours 1compartment NA NA Human Human +DTXSID4048436 Css NA 0.4493 mg/L 3compartmentss NA 50% Human Human +DTXSID4048436 Css NA 3.286 mg/L 3compartmentss NA 95% Human Human +DTXSID4048436 Css NA 0.3445 mg/L PBTK NA 50% Human Human +DTXSID4048436 Css NA 2.213 mg/L PBTK NA 95% Human Human +DTXSID4048436 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048436 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4048436 Vd NA 1.574 L/kg 1compartment NA NA Rat Human +DTXSID4048436 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4048436 TK.Half.Life NA 3.963 hours 1compartment NA NA Rat Human +DTXSID4048436 Css NA 0.05354 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048436 Css NA 0.3116 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048436 Css NA 0.04078 mg/L PBTK NA 50% Rat Human +DTXSID4048436 Css NA 0.1988 mg/L PBTK NA 95% Rat Human +DTXSID4048511 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048511 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048511 Vd NA 1.915 L/kg 1compartment NA NA Human Human DTXSID4048511 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048511 TK.Half.Life NA 2.459 hours 1compartment NA NA Human Human -DTXSID4048511 Css NA 0.06094 mg/L 3compartmentss NA 50% Human Human -DTXSID4048511 Css NA 0.5124 mg/L 3compartmentss NA 95% Human Human -DTXSID4048511 Css NA 0.04709 mg/L PBTK NA 50% Human Human -DTXSID4048511 Css NA 0.3535 mg/L PBTK NA 95% Human Human -DTXSID4048511 Clint NA 58.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048511 Fup NA 0.15 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048511 Vd NA 1.865 L/kg 1compartment NA NA Rat Human +DTXSID4048511 TK.Half.Life NA 6.205 hours 1compartment NA NA Human Human +DTXSID4048511 Css NA 0.2374 mg/L 3compartmentss NA 50% Human Human +DTXSID4048511 Css NA 1.478 mg/L 3compartmentss NA 95% Human Human +DTXSID4048511 Css NA 0.198 mg/L PBTK NA 50% Human Human +DTXSID4048511 Css NA 1.08 mg/L PBTK NA 95% Human Human +DTXSID4048511 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048511 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048511 Vd NA 1.794 L/kg 1compartment NA NA Rat Human DTXSID4048511 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048511 TK.Half.Life NA 1.066 hours 1compartment NA NA Rat Human -DTXSID4048511 Css NA 0.03371 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048511 Css NA 0.2308 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048511 Css NA 0.025 mg/L PBTK NA 50% Rat Human -DTXSID4048511 Css NA 0.1548 mg/L PBTK NA 95% Rat Human -DTXSID4048513 Clint NA 84.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048513 Fup NA 0.0049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048513 Vd NA 3.066 L/kg 1compartment NA NA Human Human -DTXSID4048513 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4048513 TK.Half.Life NA 25.7 hours 1compartment NA NA Human Human -DTXSID4048513 Css NA 0.9568 mg/L 3compartmentss NA 50% Human Human -DTXSID4048513 Css NA 5.471 mg/L 3compartmentss NA 95% Human Human -DTXSID4048513 Css NA 0.6622 mg/L PBTK NA 50% Human Human -DTXSID4048513 Css NA 3.732 mg/L PBTK NA 95% Human Human -DTXSID4048513 Clint NA 84.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048513 Fup NA 0.0049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048513 Vd NA 2.296 L/kg 1compartment NA NA Rat Human -DTXSID4048513 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4048513 TK.Half.Life NA 4.051 hours 1compartment NA NA Rat Human -DTXSID4048513 Css NA 0.5436 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048513 Css NA 2.402 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048513 Css NA 0.358 mg/L PBTK NA 50% Rat Human -DTXSID4048513 Css NA 1.606 mg/L PBTK NA 95% Rat Human -DTXSID4048519 Clint NA 103.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048519 Fup NA 0.0306 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048519 Vd NA 0.9966 L/kg 1compartment NA NA Human Human +DTXSID4048511 TK.Half.Life NA 3.228 hours 1compartment NA NA Rat Human +DTXSID4048511 Css NA 0.01058 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048511 Css NA 0.07515 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048511 Css NA 0.008794 mg/L PBTK NA 50% Rat Human +DTXSID4048511 Css NA 0.05413 mg/L PBTK NA 95% Rat Human +DTXSID4048513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048513 Fup 0.00905 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048513 Vd NA 12.21 L/kg 1compartment NA NA Human Human +DTXSID4048513 Days.Css NA 78 Days PBTK NA NA Human Human +DTXSID4048513 TK.Half.Life NA 366.4 hours 1compartment NA NA Human Human +DTXSID4048513 Css NA 1.736 mg/L 3compartmentss NA 50% Human Human +DTXSID4048513 Css NA 11 mg/L 3compartmentss NA 95% Human Human +DTXSID4048513 Css NA 2.389 mg/L PBTK NA 50% Human Human +DTXSID4048513 Css NA 14.44 mg/L PBTK NA 95% Human Human +DTXSID4048513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048513 Fup 0.00905 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048513 Vd NA 9.694 L/kg 1compartment NA NA Rat Human +DTXSID4048513 Days.Css NA 47 Days PBTK NA NA Rat Human +DTXSID4048513 TK.Half.Life NA 51.92 hours 1compartment NA NA Rat Human +DTXSID4048513 Css NA 0.2178 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048513 Css NA 1.021 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048513 Css NA 0.3117 mg/L PBTK NA 50% Rat Human +DTXSID4048513 Css NA 1.551 mg/L PBTK NA 95% Rat Human +DTXSID4048519 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048519 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048519 Vd NA 0.5633 L/kg 1compartment NA NA Human Human DTXSID4048519 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048519 TK.Half.Life NA 2.068 hours 1compartment NA NA Human Human -DTXSID4048519 Css NA 0.2144 mg/L 3compartmentss NA 50% Human Human -DTXSID4048519 Css NA 2.011 mg/L 3compartmentss NA 95% Human Human -DTXSID4048519 Css NA 0.1315 mg/L PBTK NA 50% Human Human -DTXSID4048519 Css NA 1.207 mg/L PBTK NA 95% Human Human -DTXSID4048519 Clint NA 103.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048519 Fup NA 0.0306 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048519 Vd NA 0.7502 L/kg 1compartment NA NA Rat Human +DTXSID4048519 TK.Half.Life NA 1.28 hours 1compartment NA NA Human Human +DTXSID4048519 Css NA 0.1975 mg/L 3compartmentss NA 50% Human Human +DTXSID4048519 Css NA 1.656 mg/L 3compartmentss NA 95% Human Human +DTXSID4048519 Css NA 0.1255 mg/L PBTK NA 50% Human Human +DTXSID4048519 Css NA 1.006 mg/L PBTK NA 95% Human Human +DTXSID4048519 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048519 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048519 Vd NA 0.4884 L/kg 1compartment NA NA Rat Human DTXSID4048519 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048519 TK.Half.Life NA 0.8392 hours 1compartment NA NA Rat Human -DTXSID4048519 Css NA 0.1239 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048519 Css NA 0.9561 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048519 Css NA 0.07108 mg/L PBTK NA 50% Rat Human -DTXSID4048519 Css NA 0.5359 mg/L PBTK NA 95% Rat Human -DTXSID4048640 Clint NA 200.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4048519 TK.Half.Life NA 0.64 hours 1compartment NA NA Rat Human +DTXSID4048519 Css NA 0.00952 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048519 Css NA 0.08682 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048519 Css NA 0.005866 mg/L PBTK NA 50% Rat Human +DTXSID4048519 Css NA 0.05116 mg/L PBTK NA 95% Rat Human +DTXSID4048569 Clint 3.873 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048569 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048569 Vd NA 2.016 L/kg 1compartment NA NA Human Human +DTXSID4048569 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4048569 TK.Half.Life NA 7.712 hours 1compartment NA NA Human Human +DTXSID4048569 Css NA 0.2958 mg/L 3compartmentss NA 50% Human Human +DTXSID4048569 Css NA 1.887 mg/L 3compartmentss NA 95% Human Human +DTXSID4048569 Css NA 0.2819 mg/L PBTK NA 50% Human Human +DTXSID4048569 Css NA 1.463 mg/L PBTK NA 95% Human Human +DTXSID4048569 Clint 3.873 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048569 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048569 Vd NA 1.993 L/kg 1compartment NA NA Rat Human +DTXSID4048569 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4048569 TK.Half.Life NA 4.504 hours 1compartment NA NA Rat Human +DTXSID4048569 Css NA 0.03396 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048569 Css NA 0.1629 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048569 Css NA 0.03268 mg/L PBTK NA 50% Rat Human +DTXSID4048569 Css NA 0.1218 mg/L PBTK NA 95% Rat Human +DTXSID4048640 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4048640 Fup 0.0016 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4048640 Vd NA 2.117 L/kg 1compartment NA NA Human Human -DTXSID4048640 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048640 TK.Half.Life NA 4.507 hours 1compartment NA NA Human Human -DTXSID4048640 Css NA 0.203 mg/L 3compartmentss NA 50% Human Human -DTXSID4048640 Css NA 1.647 mg/L 3compartmentss NA 95% Human Human -DTXSID4048640 Css NA 0.1304 mg/L PBTK NA 50% Human Human -DTXSID4048640 Css NA 1.014 mg/L PBTK NA 95% Human Human -DTXSID4048640 Clint NA 200.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4048640 Vd NA 0.7482 L/kg 1compartment NA NA Human Human +DTXSID4048640 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4048640 TK.Half.Life NA 26.45 hours 1compartment NA NA Human Human +DTXSID4048640 Css NA 6.306 mg/L 3compartmentss NA 50% Human Human +DTXSID4048640 Css NA 62.97 mg/L 3compartmentss NA 95% Human Human +DTXSID4048640 Css NA 3.74 mg/L PBTK NA 50% Human Human +DTXSID4048640 Css NA 36.65 mg/L PBTK NA 95% Human Human +DTXSID4048640 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4048640 Fup 0.0016 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4048640 Vd NA 1.582 L/kg 1compartment NA NA Rat Human -DTXSID4048640 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048640 TK.Half.Life NA 1.443 hours 1compartment NA NA Rat Human -DTXSID4048640 Css NA 0.1166 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048640 Css NA 0.736 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048640 Css NA 0.07059 mg/L PBTK NA 50% Rat Human -DTXSID4048640 Css NA 0.4217 mg/L PBTK NA 95% Rat Human -DTXSID4048644 Clint NA 31.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048644 Fup NA 0.1362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048644 Vd NA 1.883 L/kg 1compartment NA NA Human Human +DTXSID4048640 Vd NA 0.5736 L/kg 1compartment NA NA Rat Human +DTXSID4048640 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4048640 TK.Half.Life NA 13.14 hours 1compartment NA NA Rat Human +DTXSID4048640 Css NA 0.8422 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048640 Css NA 6.574 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048640 Css NA 0.485 mg/L PBTK NA 50% Rat Human +DTXSID4048640 Css NA 3.719 mg/L PBTK NA 95% Rat Human +DTXSID4048644 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048644 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048644 Vd NA 0.3791 L/kg 1compartment NA NA Human Human DTXSID4048644 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048644 TK.Half.Life NA 3.79 hours 1compartment NA NA Human Human -DTXSID4048644 Css NA 0.1767 mg/L 3compartmentss NA 50% Human Human -DTXSID4048644 Css NA 1.306 mg/L 3compartmentss NA 95% Human Human -DTXSID4048644 Css NA 0.1237 mg/L PBTK NA 50% Human Human -DTXSID4048644 Css NA 0.8631 mg/L PBTK NA 95% Human Human -DTXSID4048644 Clint NA 31.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048644 Fup NA 0.1362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048644 Vd NA 1.438 L/kg 1compartment NA NA Rat Human +DTXSID4048644 TK.Half.Life NA 1.496 hours 1compartment NA NA Human Human +DTXSID4048644 Css NA 0.363 mg/L 3compartmentss NA 50% Human Human +DTXSID4048644 Css NA 2.156 mg/L 3compartmentss NA 95% Human Human +DTXSID4048644 Css NA 0.2342 mg/L PBTK NA 50% Human Human +DTXSID4048644 Css NA 1.321 mg/L PBTK NA 95% Human Human +DTXSID4048644 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048644 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048644 Vd NA 0.3589 L/kg 1compartment NA NA Rat Human DTXSID4048644 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048644 TK.Half.Life NA 1.313 hours 1compartment NA NA Rat Human -DTXSID4048644 Css NA 0.09739 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048644 Css NA 0.5563 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048644 Css NA 0.06507 mg/L PBTK NA 50% Rat Human -DTXSID4048644 Css NA 0.3512 mg/L PBTK NA 95% Rat Human -DTXSID4048646 Clint NA 4.836 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048646 Fup NA 0.1495 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048646 Vd NA 0.2674 L/kg 1compartment NA NA Human Human +DTXSID4048644 TK.Half.Life NA 0.8362 hours 1compartment NA NA Rat Human +DTXSID4048644 Css NA 0.01678 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048644 Css NA 0.1071 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048644 Css NA 0.01056 mg/L PBTK NA 50% Rat Human +DTXSID4048644 Css NA 0.06398 mg/L PBTK NA 95% Rat Human +DTXSID4048646 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048646 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048646 Vd NA 0.3212 L/kg 1compartment NA NA Human Human DTXSID4048646 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048646 TK.Half.Life NA 1.477 hours 1compartment NA NA Human Human -DTXSID4048646 Css NA 0.7669 mg/L 3compartmentss NA 50% Human Human -DTXSID4048646 Css NA 4.916 mg/L 3compartmentss NA 95% Human Human -DTXSID4048646 Css NA 0.4701 mg/L PBTK NA 50% Human Human -DTXSID4048646 Css NA 2.902 mg/L PBTK NA 95% Human Human -DTXSID4048646 Clint NA 4.836 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048646 Fup NA 0.1495 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048646 Vd NA 0.2699 L/kg 1compartment NA NA Rat Human +DTXSID4048646 TK.Half.Life NA 0.7524 hours 1compartment NA NA Human Human +DTXSID4048646 Css NA 0.2086 mg/L 3compartmentss NA 50% Human Human +DTXSID4048646 Css NA 1.267 mg/L 3compartmentss NA 95% Human Human +DTXSID4048646 Css NA 0.139 mg/L PBTK NA 50% Human Human +DTXSID4048646 Css NA 0.79 mg/L PBTK NA 95% Human Human +DTXSID4048646 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048646 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048646 Vd NA 0.3365 L/kg 1compartment NA NA Rat Human DTXSID4048646 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048646 TK.Half.Life NA 0.8824 hours 1compartment NA NA Rat Human -DTXSID4048646 Css NA 0.392 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048646 Css NA 1.806 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048646 Css NA 0.2277 mg/L PBTK NA 50% Rat Human -DTXSID4048646 Css NA 1.001 mg/L PBTK NA 95% Rat Human -DTXSID4048648 Clint NA 355.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048648 Fup NA 0.0346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048648 Vd NA 2.596 L/kg 1compartment NA NA Human Human -DTXSID4048648 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048648 TK.Half.Life NA 3.001 hours 1compartment NA NA Human Human -DTXSID4048648 Css NA 0.05114 mg/L 3compartmentss NA 50% Human Human -DTXSID4048648 Css NA 0.3744 mg/L 3compartmentss NA 95% Human Human -DTXSID4048648 Css NA 0.03503 mg/L PBTK NA 50% Human Human -DTXSID4048648 Css NA 0.2426 mg/L PBTK NA 95% Human Human -DTXSID4048648 Clint NA 355.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048648 Fup NA 0.0346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048648 Vd NA 2.014 L/kg 1compartment NA NA Rat Human +DTXSID4048646 TK.Half.Life NA 0.4426 hours 1compartment NA NA Rat Human +DTXSID4048646 Css NA 0.02468 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048646 Css NA 0.1155 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048646 Css NA 0.01603 mg/L PBTK NA 50% Rat Human +DTXSID4048646 Css NA 0.06955 mg/L PBTK NA 95% Rat Human +DTXSID4048648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048648 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048648 Vd NA 2.178 L/kg 1compartment NA NA Human Human +DTXSID4048648 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4048648 TK.Half.Life NA 15.13 hours 1compartment NA NA Human Human +DTXSID4048648 Css NA 0.9587 mg/L 3compartmentss NA 50% Human Human +DTXSID4048648 Css NA 8.176 mg/L 3compartmentss NA 95% Human Human +DTXSID4048648 Css NA 0.636 mg/L PBTK NA 50% Human Human +DTXSID4048648 Css NA 5.193 mg/L PBTK NA 95% Human Human +DTXSID4048648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048648 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048648 Vd NA 1.695 L/kg 1compartment NA NA Rat Human DTXSID4048648 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048648 TK.Half.Life NA 0.9614 hours 1compartment NA NA Rat Human -DTXSID4048648 Css NA 0.02895 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048648 Css NA 0.1695 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048648 Css NA 0.01897 mg/L PBTK NA 50% Rat Human -DTXSID4048648 Css NA 0.1029 mg/L PBTK NA 95% Rat Human -DTXSID4048690 Clint NA 837.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4048648 TK.Half.Life NA 5.192 hours 1compartment NA NA Rat Human +DTXSID4048648 Css NA 0.1231 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048648 Css NA 0.8501 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048648 Css NA 0.08066 mg/L PBTK NA 50% Rat Human +DTXSID4048648 Css NA 0.5316 mg/L PBTK NA 95% Rat Human +DTXSID4048690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4048690 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4048690 Vd NA 1.932 L/kg 1compartment NA NA Human Human -DTXSID4048690 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048690 TK.Half.Life NA 2.163 hours 1compartment NA NA Human Human -DTXSID4048690 Css NA 0.04039 mg/L 3compartmentss NA 50% Human Human -DTXSID4048690 Css NA 0.35 mg/L 3compartmentss NA 95% Human Human -DTXSID4048690 Css NA 0.02587 mg/L PBTK NA 50% Human Human -DTXSID4048690 Css NA 0.2164 mg/L PBTK NA 95% Human Human -DTXSID4048690 Clint NA 837.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4048690 Vd NA 1.774 L/kg 1compartment NA NA Human Human +DTXSID4048690 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4048690 TK.Half.Life NA 17.14 hours 1compartment NA NA Human Human +DTXSID4048690 Css NA 1.296 mg/L 3compartmentss NA 50% Human Human +DTXSID4048690 Css NA 10.91 mg/L 3compartmentss NA 95% Human Human +DTXSID4048690 Css NA 0.8276 mg/L PBTK NA 50% Human Human +DTXSID4048690 Css NA 6.632 mg/L PBTK NA 95% Human Human +DTXSID4048690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4048690 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4048690 Vd NA 1.436 L/kg 1compartment NA NA Rat Human +DTXSID4048690 Vd NA 1.317 L/kg 1compartment NA NA Rat Human DTXSID4048690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048690 TK.Half.Life NA 0.71 hours 1compartment NA NA Rat Human -DTXSID4048690 Css NA 0.023 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048690 Css NA 0.1658 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048690 Css NA 0.01389 mg/L PBTK NA 50% Rat Human -DTXSID4048690 Css NA 0.09606 mg/L PBTK NA 95% Rat Human -DTXSID4048692 Clint NA 0.4848 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048692 Fup NA 0.478 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048692 Vd NA 1.255 L/kg 1compartment NA NA Human Human +DTXSID4048690 TK.Half.Life NA 6.027 hours 1compartment NA NA Rat Human +DTXSID4048690 Css NA 0.06499 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048690 Css NA 0.6149 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048690 Css NA 0.03967 mg/L PBTK NA 50% Rat Human +DTXSID4048690 Css NA 0.3665 mg/L PBTK NA 95% Rat Human +DTXSID4048692 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048692 Fup 0.45 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048692 Vd NA 1.025 L/kg 1compartment NA NA Human Human DTXSID4048692 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4048692 TK.Half.Life NA 10.6 hours 1compartment NA NA Human Human -DTXSID4048692 Css NA 0.836 mg/L 3compartmentss NA 50% Human Human -DTXSID4048692 Css NA 4.302 mg/L 3compartmentss NA 95% Human Human -DTXSID4048692 Css NA 0.6886 mg/L PBTK NA 50% Human Human -DTXSID4048692 Css NA 2.84 mg/L PBTK NA 95% Human Human -DTXSID4048692 Clint NA 0.4848 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048692 Fup NA 0.478 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048692 Vd NA 1.09 L/kg 1compartment NA NA Rat Human +DTXSID4048692 TK.Half.Life NA 15.72 hours 1compartment NA NA Human Human +DTXSID4048692 Css NA 1.539 mg/L 3compartmentss NA 50% Human Human +DTXSID4048692 Css NA 7.366 mg/L 3compartmentss NA 95% Human Human +DTXSID4048692 Css NA 1.242 mg/L PBTK NA 50% Human Human +DTXSID4048692 Css NA 4.87 mg/L PBTK NA 95% Human Human +DTXSID4048692 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048692 Fup 0.45 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048692 Vd NA 0.9191 L/kg 1compartment NA NA Rat Human DTXSID4048692 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048692 TK.Half.Life NA 3.711 hours 1compartment NA NA Rat Human -DTXSID4048692 Css NA 0.2958 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048692 Css NA 1.414 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048692 Css NA 0.2355 mg/L PBTK NA 50% Rat Human -DTXSID4048692 Css NA 0.8684 mg/L PBTK NA 95% Rat Human -DTXSID4048694 Clint NA 1.162 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048694 Fup NA 0.7125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048694 Vd NA 0.967 L/kg 1compartment NA NA Human Human +DTXSID4048692 TK.Half.Life NA 4.575 hours 1compartment NA NA Rat Human +DTXSID4048692 Css NA 0.09866 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048692 Css NA 0.4006 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048692 Css NA 0.07855 mg/L PBTK NA 50% Rat Human +DTXSID4048692 Css NA 0.2537 mg/L PBTK NA 95% Rat Human +DTXSID4048694 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048694 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048694 Vd NA 0.679 L/kg 1compartment NA NA Human Human DTXSID4048694 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048694 TK.Half.Life NA 3.315 hours 1compartment NA NA Human Human -DTXSID4048694 Css NA 0.3581 mg/L 3compartmentss NA 50% Human Human -DTXSID4048694 Css NA 2.503 mg/L 3compartmentss NA 95% Human Human -DTXSID4048694 Css NA 0.3057 mg/L PBTK NA 50% Human Human -DTXSID4048694 Css NA 1.65 mg/L PBTK NA 95% Human Human -DTXSID4048694 Clint NA 1.162 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048694 Fup NA 0.7125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048694 Vd NA 0.9329 L/kg 1compartment NA NA Rat Human +DTXSID4048694 TK.Half.Life NA 1.405 hours 1compartment NA NA Human Human +DTXSID4048694 Css NA 0.1685 mg/L 3compartmentss NA 50% Human Human +DTXSID4048694 Css NA 1.082 mg/L 3compartmentss NA 95% Human Human +DTXSID4048694 Css NA 0.125 mg/L PBTK NA 50% Human Human +DTXSID4048694 Css NA 0.7398 mg/L PBTK NA 95% Human Human +DTXSID4048694 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048694 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048694 Vd NA 0.6522 L/kg 1compartment NA NA Rat Human DTXSID4048694 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048694 TK.Half.Life NA 1.553 hours 1compartment NA NA Rat Human -DTXSID4048694 Css NA 0.1373 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048694 Css NA 0.9908 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048694 Css NA 0.115 mg/L PBTK NA 50% Rat Human -DTXSID4048694 Css NA 0.5946 mg/L PBTK NA 95% Rat Human -DTXSID4048696 Clint NA 5.498 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048696 Fup NA 0.0904 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048696 Vd NA 0.2445 L/kg 1compartment NA NA Human Human +DTXSID4048694 TK.Half.Life NA 0.7512 hours 1compartment NA NA Rat Human +DTXSID4048694 Css NA 0.01917 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048694 Css NA 0.0977 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048694 Css NA 0.01431 mg/L PBTK NA 50% Rat Human +DTXSID4048694 Css NA 0.06287 mg/L PBTK NA 95% Rat Human +DTXSID4048696 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048696 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048696 Vd NA 0.3433 L/kg 1compartment NA NA Human Human DTXSID4048696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048696 TK.Half.Life NA 1.917 hours 1compartment NA NA Human Human -DTXSID4048696 Css NA 1.239 mg/L 3compartmentss NA 50% Human Human -DTXSID4048696 Css NA 8.1 mg/L 3compartmentss NA 95% Human Human -DTXSID4048696 Css NA 0.7477 mg/L PBTK NA 50% Human Human -DTXSID4048696 Css NA 4.776 mg/L PBTK NA 95% Human Human -DTXSID4048696 Clint NA 5.498 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048696 Fup NA 0.0904 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048696 Vd NA 0.2405 L/kg 1compartment NA NA Rat Human +DTXSID4048696 TK.Half.Life NA 1.096 hours 1compartment NA NA Human Human +DTXSID4048696 Css NA 0.3232 mg/L 3compartmentss NA 50% Human Human +DTXSID4048696 Css NA 1.882 mg/L 3compartmentss NA 95% Human Human +DTXSID4048696 Css NA 0.2098 mg/L PBTK NA 50% Human Human +DTXSID4048696 Css NA 1.152 mg/L PBTK NA 95% Human Human +DTXSID4048696 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048696 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048696 Vd NA 0.3397 L/kg 1compartment NA NA Rat Human DTXSID4048696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048696 TK.Half.Life NA 1.147 hours 1compartment NA NA Rat Human -DTXSID4048696 Css NA 0.6454 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048696 Css NA 3.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048696 Css NA 0.3652 mg/L PBTK NA 50% Rat Human -DTXSID4048696 Css NA 1.767 mg/L PBTK NA 95% Rat Human -DTXSID4048698 Clint NA 116.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048698 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048698 Vd NA 3.391 L/kg 1compartment NA NA Human Human -DTXSID4048698 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048698 TK.Half.Life NA 4.492 hours 1compartment NA NA Human Human -DTXSID4048698 Css NA 0.06567 mg/L 3compartmentss NA 50% Human Human -DTXSID4048698 Css NA 0.4261 mg/L 3compartmentss NA 95% Human Human -DTXSID4048698 Css NA 0.0488 mg/L PBTK NA 50% Human Human -DTXSID4048698 Css NA 0.3105 mg/L PBTK NA 95% Human Human -DTXSID4048698 Clint NA 116.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048698 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048698 Vd NA 2.637 L/kg 1compartment NA NA Rat Human -DTXSID4048698 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048698 TK.Half.Life NA 1.134 hours 1compartment NA NA Rat Human -DTXSID4048698 Css NA 0.03663 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048698 Css NA 0.1982 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048698 Css NA 0.02618 mg/L PBTK NA 50% Rat Human -DTXSID4048698 Css NA 0.1363 mg/L PBTK NA 95% Rat Human -DTXSID4048721 Clint NA 14.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048721 Fup NA 0.2734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048721 Vd NA 2.21 L/kg 1compartment NA NA Human Human +DTXSID4048696 TK.Half.Life NA 0.629 hours 1compartment NA NA Rat Human +DTXSID4048696 Css NA 0.03815 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048696 Css NA 0.1632 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048696 Css NA 0.0243 mg/L PBTK NA 50% Rat Human +DTXSID4048696 Css NA 0.09717 mg/L PBTK NA 95% Rat Human +DTXSID4048721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048721 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048721 Vd NA 2.047 L/kg 1compartment NA NA Human Human DTXSID4048721 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048721 TK.Half.Life NA 5.056 hours 1compartment NA NA Human Human -DTXSID4048721 Css NA 0.1904 mg/L 3compartmentss NA 50% Human Human -DTXSID4048721 Css NA 1.166 mg/L 3compartmentss NA 95% Human Human -DTXSID4048721 Css NA 0.1422 mg/L PBTK NA 50% Human Human -DTXSID4048721 Css NA 0.8347 mg/L PBTK NA 95% Human Human -DTXSID4048721 Clint NA 14.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048721 Fup NA 0.2734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048721 Vd NA 1.711 L/kg 1compartment NA NA Rat Human +DTXSID4048721 TK.Half.Life NA 4.119 hours 1compartment NA NA Human Human +DTXSID4048721 Css NA 0.1476 mg/L 3compartmentss NA 50% Human Human +DTXSID4048721 Css NA 1.015 mg/L 3compartmentss NA 95% Human Human +DTXSID4048721 Css NA 0.1074 mg/L PBTK NA 50% Human Human +DTXSID4048721 Css NA 0.7041 mg/L PBTK NA 95% Human Human +DTXSID4048721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048721 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048721 Vd NA 1.58 L/kg 1compartment NA NA Rat Human DTXSID4048721 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048721 TK.Half.Life NA 1.616 hours 1compartment NA NA Rat Human -DTXSID4048721 Css NA 0.101 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048721 Css NA 0.4718 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048721 Css NA 0.07292 mg/L PBTK NA 50% Rat Human -DTXSID4048721 Css NA 0.3157 mg/L PBTK NA 95% Rat Human -DTXSID4048725 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048725 Fup NA 0.3135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048725 Vd NA 0.3982 L/kg 1compartment NA NA Human Human +DTXSID4048721 TK.Half.Life NA 1.388 hours 1compartment NA NA Rat Human +DTXSID4048721 Css NA 0.01886 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048721 Css NA 0.09731 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048721 Css NA 0.01361 mg/L PBTK NA 50% Rat Human +DTXSID4048721 Css NA 0.06749 mg/L PBTK NA 95% Rat Human +DTXSID4048723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048723 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048723 Vd NA 0.9891 L/kg 1compartment NA NA Human Human +DTXSID4048723 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4048723 TK.Half.Life NA 1.185 hours 1compartment NA NA Human Human +DTXSID4048723 Css NA 0.05789 mg/L 3compartmentss NA 50% Human Human +DTXSID4048723 Css NA 0.4409 mg/L 3compartmentss NA 95% Human Human +DTXSID4048723 Css NA 0.04485 mg/L PBTK NA 50% Human Human +DTXSID4048723 Css NA 0.3105 mg/L PBTK NA 95% Human Human +DTXSID4048723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048723 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048723 Vd NA 0.9958 L/kg 1compartment NA NA Rat Human +DTXSID4048723 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4048723 TK.Half.Life NA 0.6353 hours 1compartment NA NA Rat Human +DTXSID4048723 Css NA 0.007069 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048723 Css NA 0.04422 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048723 Css NA 0.005488 mg/L PBTK NA 50% Rat Human +DTXSID4048723 Css NA 0.02986 mg/L PBTK NA 95% Rat Human +DTXSID4048725 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048725 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048725 Vd NA 0.5067 L/kg 1compartment NA NA Human Human DTXSID4048725 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048725 TK.Half.Life NA 8.218 hours 1compartment NA NA Human Human -DTXSID4048725 Css NA 2.439 mg/L 3compartmentss NA 50% Human Human -DTXSID4048725 Css NA 9.61 mg/L 3compartmentss NA 95% Human Human -DTXSID4048725 Css NA 1.694 mg/L PBTK NA 50% Human Human -DTXSID4048725 Css NA 6.028 mg/L PBTK NA 95% Human Human -DTXSID4048725 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048725 Fup NA 0.3135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048725 Vd NA 0.4011 L/kg 1compartment NA NA Rat Human +DTXSID4048725 TK.Half.Life NA 0.8665 hours 1compartment NA NA Human Human +DTXSID4048725 Css NA 0.1298 mg/L 3compartmentss NA 50% Human Human +DTXSID4048725 Css NA 0.9796 mg/L 3compartmentss NA 95% Human Human +DTXSID4048725 Css NA 0.09751 mg/L PBTK NA 50% Human Human +DTXSID4048725 Css NA 0.6529 mg/L PBTK NA 95% Human Human +DTXSID4048725 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048725 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048725 Vd NA 0.5123 L/kg 1compartment NA NA Rat Human DTXSID4048725 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048725 TK.Half.Life NA 2.821 hours 1compartment NA NA Rat Human -DTXSID4048725 Css NA 0.6784 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048725 Css NA 2.252 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048725 Css NA 0.4454 mg/L PBTK NA 50% Rat Human -DTXSID4048725 Css NA 1.306 mg/L PBTK NA 95% Rat Human -DTXSID4048727 Clint NA 20.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048727 Fup NA 0.1222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048727 Vd NA 0.5122 L/kg 1compartment NA NA Human Human +DTXSID4048725 TK.Half.Life NA 0.479 hours 1compartment NA NA Rat Human +DTXSID4048725 Css NA 0.01516 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048725 Css NA 0.08862 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048725 Css NA 0.01132 mg/L PBTK NA 50% Rat Human +DTXSID4048725 Css NA 0.05605 mg/L PBTK NA 95% Rat Human +DTXSID4048727 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048727 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048727 Vd NA 0.3896 L/kg 1compartment NA NA Human Human DTXSID4048727 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048727 TK.Half.Life NA 1.167 hours 1compartment NA NA Human Human -DTXSID4048727 Css NA 0.235 mg/L 3compartmentss NA 50% Human Human -DTXSID4048727 Css NA 1.903 mg/L 3compartmentss NA 95% Human Human -DTXSID4048727 Css NA 0.1522 mg/L PBTK NA 50% Human Human -DTXSID4048727 Css NA 1.172 mg/L PBTK NA 95% Human Human -DTXSID4048727 Clint NA 20.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048727 Fup NA 0.1222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048727 Vd NA 0.4503 L/kg 1compartment NA NA Rat Human +DTXSID4048727 TK.Half.Life NA 0.6762 hours 1compartment NA NA Human Human +DTXSID4048727 Css NA 0.1182 mg/L 3compartmentss NA 50% Human Human +DTXSID4048727 Css NA 0.8318 mg/L 3compartmentss NA 95% Human Human +DTXSID4048727 Css NA 0.07784 mg/L PBTK NA 50% Human Human +DTXSID4048727 Css NA 0.5286 mg/L PBTK NA 95% Human Human +DTXSID4048727 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048727 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048727 Vd NA 0.3737 L/kg 1compartment NA NA Rat Human DTXSID4048727 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048727 TK.Half.Life NA 0.594 hours 1compartment NA NA Rat Human -DTXSID4048727 Css NA 0.131 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048727 Css NA 0.7868 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048727 Css NA 0.08002 mg/L PBTK NA 50% Rat Human -DTXSID4048727 Css NA 0.4478 mg/L PBTK NA 95% Rat Human +DTXSID4048727 TK.Half.Life NA 0.361 hours 1compartment NA NA Rat Human +DTXSID4048727 Css NA 0.0151 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048727 Css NA 0.08108 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048727 Css NA 0.009754 mg/L PBTK NA 50% Rat Human +DTXSID4048727 Css NA 0.05028 mg/L PBTK NA 95% Rat Human DTXSID4048729 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4048729 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4048729 Vd NA 0.5386 L/kg 1compartment NA NA Human Human DTXSID4048729 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID4048729 TK.Half.Life NA 3.487 hours 1compartment NA NA Human Human -DTXSID4048729 Css NA 0.9116 mg/L 3compartmentss NA 50% Human Human -DTXSID4048729 Css NA 5.669 mg/L 3compartmentss NA 95% Human Human -DTXSID4048729 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID4048729 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID4048729 Css NA 0.7688 mg/L 3compartmentss NA 50% Human Human +DTXSID4048729 Css NA 5.209 mg/L 3compartmentss NA 95% Human Human +DTXSID4048729 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID4048729 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID4048729 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4048729 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4048729 Vd NA 0.5791 L/kg 1compartment NA NA Rat Human DTXSID4048729 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4048729 TK.Half.Life NA 1.277 hours 1compartment NA NA Rat Human -DTXSID4048729 Css NA 0.2312 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048729 Css NA 1.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048729 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID4048729 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID4048771 Clint NA 10.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048771 Fup NA 0.084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048771 Vd NA 3.131 L/kg 1compartment NA NA Human Human -DTXSID4048771 Days.Css NA 29 Days PBTK NA NA Human Human -DTXSID4048771 TK.Half.Life NA 156.8 hours 1compartment NA NA Human Human -DTXSID4048771 Css NA 6.212 mg/L 3compartmentss NA 50% Human Human -DTXSID4048771 Css NA 39.17 mg/L 3compartmentss NA 95% Human Human -DTXSID4048771 Css NA 4.32 mg/L PBTK NA 50% Human Human -DTXSID4048771 Css NA 26.25 mg/L PBTK NA 95% Human Human -DTXSID4048771 Clint NA 10.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048771 Fup NA 0.084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4048729 Css NA 0.0142 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048729 Css NA 0.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048729 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID4048729 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID4048771 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048771 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048771 Vd NA 3.124 L/kg 1compartment NA NA Human Human +DTXSID4048771 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4048771 TK.Half.Life NA 46.83 hours 1compartment NA NA Human Human +DTXSID4048771 Css NA 1.682 mg/L 3compartmentss NA 50% Human Human +DTXSID4048771 Css NA 10.75 mg/L 3compartmentss NA 95% Human Human +DTXSID4048771 Css NA 1.172 mg/L PBTK NA 50% Human Human +DTXSID4048771 Css NA 7.225 mg/L PBTK NA 95% Human Human +DTXSID4048771 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048771 Fup 0.182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4048771 Vd NA 2.347 L/kg 1compartment NA NA Rat Human -DTXSID4048771 Days.Css NA 16 Days PBTK NA NA Rat Human -DTXSID4048771 TK.Half.Life NA 20.44 hours 1compartment NA NA Rat Human -DTXSID4048771 Css NA 3.415 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048771 Css NA 17.54 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048771 Css NA 2.277 mg/L PBTK NA 50% Rat Human -DTXSID4048771 Css NA 11.22 mg/L PBTK NA 95% Rat Human -DTXSID4048773 Clint NA 22.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4048771 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4048771 TK.Half.Life NA 6.627 hours 1compartment NA NA Rat Human +DTXSID4048771 Css NA 0.2168 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048771 Css NA 1.164 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048771 Css NA 0.1514 mg/L PBTK NA 50% Rat Human +DTXSID4048771 Css NA 0.7761 mg/L PBTK NA 95% Rat Human +DTXSID4048773 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4048773 Fup 0.0011 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4048773 Vd NA 0.1626 L/kg 1compartment NA NA Human Human -DTXSID4048773 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4048773 TK.Half.Life NA 25.28 hours 1compartment NA NA Human Human -DTXSID4048773 Css NA 29.88 mg/L 3compartmentss NA 50% Human Human -DTXSID4048773 Css NA 261.8 mg/L 3compartmentss NA 95% Human Human -DTXSID4048773 Css NA 17.3 mg/L PBTK NA 50% Human Human -DTXSID4048773 Css NA 151.3 mg/L PBTK NA 95% Human Human -DTXSID4048773 Clint NA 22.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4048773 Vd NA 0.1674 L/kg 1compartment NA NA Human Human +DTXSID4048773 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID4048773 TK.Half.Life NA 86.2 hours 1compartment NA NA Human Human +DTXSID4048773 Css NA 83.07 mg/L 3compartmentss NA 50% Human Human +DTXSID4048773 Css NA 680.1 mg/L 3compartmentss NA 95% Human Human +DTXSID4048773 Css NA 48.21 mg/L PBTK NA 50% Human Human +DTXSID4048773 Css NA 388.1 mg/L PBTK NA 95% Human Human +DTXSID4048773 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4048773 Fup 0.0011 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4048773 Vd NA 0.1608 L/kg 1compartment NA NA Rat Human -DTXSID4048773 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4048773 TK.Half.Life NA 17.03 hours 1compartment NA NA Rat Human -DTXSID4048773 Css NA 17.03 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048773 Css NA 120.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048773 Css NA 9.207 mg/L PBTK NA 50% Rat Human -DTXSID4048773 Css NA 65.19 mg/L PBTK NA 95% Rat Human -DTXSID4048775 Clint NA 15.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048775 Fup NA 0.2251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048775 Vd NA 2.117 L/kg 1compartment NA NA Human Human +DTXSID4048773 Vd NA 0.1645 L/kg 1compartment NA NA Rat Human +DTXSID4048773 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID4048773 TK.Half.Life NA 54.41 hours 1compartment NA NA Rat Human +DTXSID4048773 Css NA 3.912 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048773 Css NA 36.16 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048773 Css NA 2.159 mg/L PBTK NA 50% Rat Human +DTXSID4048773 Css NA 20.13 mg/L PBTK NA 95% Rat Human +DTXSID4048775 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048775 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048775 Vd NA 1.663 L/kg 1compartment NA NA Human Human DTXSID4048775 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048775 TK.Half.Life NA 3.956 hours 1compartment NA NA Human Human -DTXSID4048775 Css NA 0.1347 mg/L 3compartmentss NA 50% Human Human -DTXSID4048775 Css NA 0.9069 mg/L 3compartmentss NA 95% Human Human -DTXSID4048775 Css NA 0.11 mg/L PBTK NA 50% Human Human -DTXSID4048775 Css NA 0.669 mg/L PBTK NA 95% Human Human -DTXSID4048775 Clint NA 15.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048775 Fup NA 0.2251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048775 Vd NA 1.869 L/kg 1compartment NA NA Rat Human +DTXSID4048775 TK.Half.Life NA 1.935 hours 1compartment NA NA Human Human +DTXSID4048775 Css NA 0.05563 mg/L 3compartmentss NA 50% Human Human +DTXSID4048775 Css NA 0.4194 mg/L 3compartmentss NA 95% Human Human +DTXSID4048775 Css NA 0.0466 mg/L PBTK NA 50% Human Human +DTXSID4048775 Css NA 0.31 mg/L PBTK NA 95% Human Human +DTXSID4048775 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048775 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048775 Vd NA 1.587 L/kg 1compartment NA NA Rat Human DTXSID4048775 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048775 TK.Half.Life NA 1.774 hours 1compartment NA NA Rat Human -DTXSID4048775 Css NA 0.0721 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048775 Css NA 0.3609 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048775 Css NA 0.05659 mg/L PBTK NA 50% Rat Human -DTXSID4048775 Css NA 0.2539 mg/L PBTK NA 95% Rat Human -DTXSID4048777 Clint NA 33.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048777 Fup NA 0.1376 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048777 Vd NA 2.452 L/kg 1compartment NA NA Human Human +DTXSID4048775 TK.Half.Life NA 0.97 hours 1compartment NA NA Rat Human +DTXSID4048775 Css NA 0.006788 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048775 Css NA 0.04195 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048775 Css NA 0.005776 mg/L PBTK NA 50% Rat Human +DTXSID4048775 Css NA 0.03081 mg/L PBTK NA 95% Rat Human +DTXSID4048777 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048777 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048777 Vd NA 2.533 L/kg 1compartment NA NA Human Human DTXSID4048777 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048777 TK.Half.Life NA 6.001 hours 1compartment NA NA Human Human -DTXSID4048777 Css NA 0.2274 mg/L 3compartmentss NA 50% Human Human -DTXSID4048777 Css NA 1.567 mg/L 3compartmentss NA 95% Human Human -DTXSID4048777 Css NA 0.1592 mg/L PBTK NA 50% Human Human -DTXSID4048777 Css NA 1.039 mg/L PBTK NA 95% Human Human -DTXSID4048777 Clint NA 33.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048777 Fup NA 0.1376 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048777 Vd NA 1.861 L/kg 1compartment NA NA Rat Human +DTXSID4048777 TK.Half.Life NA 5.271 hours 1compartment NA NA Human Human +DTXSID4048777 Css NA 0.1546 mg/L 3compartmentss NA 50% Human Human +DTXSID4048777 Css NA 1.013 mg/L 3compartmentss NA 95% Human Human +DTXSID4048777 Css NA 0.1158 mg/L PBTK NA 50% Human Human +DTXSID4048777 Css NA 0.7219 mg/L PBTK NA 95% Human Human +DTXSID4048777 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048777 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048777 Vd NA 1.95 L/kg 1compartment NA NA Rat Human DTXSID4048777 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048777 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human -DTXSID4048777 Css NA 0.1263 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048777 Css NA 0.705 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048777 Css NA 0.08472 mg/L PBTK NA 50% Rat Human -DTXSID4048777 Css NA 0.4475 mg/L PBTK NA 95% Rat Human -DTXSID4048779 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048779 Fup NA 0.2773 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048779 Vd NA 0.2818 L/kg 1compartment NA NA Human Human +DTXSID4048777 TK.Half.Life NA 1.503 hours 1compartment NA NA Rat Human +DTXSID4048777 Css NA 0.01929 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048777 Css NA 0.09986 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048777 Css NA 0.01449 mg/L PBTK NA 50% Rat Human +DTXSID4048777 Css NA 0.07199 mg/L PBTK NA 95% Rat Human +DTXSID4048779 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048779 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048779 Vd NA 0.341 L/kg 1compartment NA NA Human Human DTXSID4048779 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048779 TK.Half.Life NA 6.576 hours 1compartment NA NA Human Human -DTXSID4048779 Css NA 2.976 mg/L 3compartmentss NA 50% Human Human -DTXSID4048779 Css NA 11.27 mg/L 3compartmentss NA 95% Human Human -DTXSID4048779 Css NA 1.915 mg/L PBTK NA 50% Human Human -DTXSID4048779 Css NA 6.821 mg/L PBTK NA 95% Human Human -DTXSID4048779 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048779 Fup NA 0.2773 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048779 Vd NA 0.2903 L/kg 1compartment NA NA Rat Human +DTXSID4048779 TK.Half.Life NA 4.715 hours 1compartment NA NA Human Human +DTXSID4048779 Css NA 1.406 mg/L 3compartmentss NA 50% Human Human +DTXSID4048779 Css NA 6.74 mg/L 3compartmentss NA 95% Human Human +DTXSID4048779 Css NA 0.9746 mg/L PBTK NA 50% Human Human +DTXSID4048779 Css NA 4.094 mg/L PBTK NA 95% Human Human +DTXSID4048779 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048779 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048779 Vd NA 0.3622 L/kg 1compartment NA NA Rat Human DTXSID4048779 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048779 TK.Half.Life NA 2.308 hours 1compartment NA NA Rat Human -DTXSID4048779 Css NA 0.8288 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048779 Css NA 2.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048779 Css NA 0.503 mg/L PBTK NA 50% Rat Human -DTXSID4048779 Css NA 1.448 mg/L PBTK NA 95% Rat Human -DTXSID4048800 Clint NA 47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048800 Fup NA 0.0582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048800 Vd NA 2.287 L/kg 1compartment NA NA Human Human +DTXSID4048779 TK.Half.Life NA 1.707 hours 1compartment NA NA Rat Human +DTXSID4048779 Css NA 0.02667 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048779 Css NA 0.1696 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048779 Css NA 0.01768 mg/L PBTK NA 50% Rat Human +DTXSID4048779 Css NA 0.1028 mg/L PBTK NA 95% Rat Human +DTXSID4048800 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048800 Fup 0.0863 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048800 Vd NA 2.521 L/kg 1compartment NA NA Human Human DTXSID4048800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048800 TK.Half.Life NA 6.956 hours 1compartment NA NA Human Human -DTXSID4048800 Css NA 0.3332 mg/L 3compartmentss NA 50% Human Human -DTXSID4048800 Css NA 2.263 mg/L 3compartmentss NA 95% Human Human -DTXSID4048800 Css NA 0.2229 mg/L PBTK NA 50% Human Human -DTXSID4048800 Css NA 1.44 mg/L PBTK NA 95% Human Human -DTXSID4048800 Clint NA 47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048800 Fup NA 0.0582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048800 Vd NA 1.718 L/kg 1compartment NA NA Rat Human +DTXSID4048800 TK.Half.Life NA 12.5 hours 1compartment NA NA Human Human +DTXSID4048800 Css NA 0.5665 mg/L 3compartmentss NA 50% Human Human +DTXSID4048800 Css NA 3.825 mg/L 3compartmentss NA 95% Human Human +DTXSID4048800 Css NA 0.3892 mg/L PBTK NA 50% Human Human +DTXSID4048800 Css NA 2.537 mg/L PBTK NA 95% Human Human +DTXSID4048800 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048800 Fup 0.0863 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048800 Vd NA 1.899 L/kg 1compartment NA NA Rat Human DTXSID4048800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048800 TK.Half.Life NA 2.062 hours 1compartment NA NA Rat Human -DTXSID4048800 Css NA 0.1884 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048800 Css NA 1.059 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048800 Css NA 0.1195 mg/L PBTK NA 50% Rat Human -DTXSID4048800 Css NA 0.6336 mg/L PBTK NA 95% Rat Human -DTXSID4048802 Clint NA 10.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048802 Fup NA 0.5072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048802 Vd NA 1.512 L/kg 1compartment NA NA Human Human +DTXSID4048800 TK.Half.Life NA 3.228 hours 1compartment NA NA Rat Human +DTXSID4048800 Css NA 0.07286 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048800 Css NA 0.4057 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048800 Css NA 0.04912 mg/L PBTK NA 50% Rat Human +DTXSID4048800 Css NA 0.2611 mg/L PBTK NA 95% Rat Human +DTXSID4048802 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048802 Fup 0.514 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048802 Vd NA 1.562 L/kg 1compartment NA NA Human Human DTXSID4048802 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048802 TK.Half.Life NA 1.998 hours 1compartment NA NA Human Human -DTXSID4048802 Css NA 0.08135 mg/L 3compartmentss NA 50% Human Human -DTXSID4048802 Css NA 0.6379 mg/L 3compartmentss NA 95% Human Human -DTXSID4048802 Css NA 0.0689 mg/L PBTK NA 50% Human Human -DTXSID4048802 Css NA 0.4563 mg/L PBTK NA 95% Human Human -DTXSID4048802 Clint NA 10.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048802 Fup NA 0.5072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048802 Vd NA 1.345 L/kg 1compartment NA NA Rat Human +DTXSID4048802 TK.Half.Life NA 2.736 hours 1compartment NA NA Human Human +DTXSID4048802 Css NA 0.1094 mg/L 3compartmentss NA 50% Human Human +DTXSID4048802 Css NA 0.8342 mg/L 3compartmentss NA 95% Human Human +DTXSID4048802 Css NA 0.09316 mg/L PBTK NA 50% Human Human +DTXSID4048802 Css NA 0.595 mg/L PBTK NA 95% Human Human +DTXSID4048802 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048802 Fup 0.514 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048802 Vd NA 1.384 L/kg 1compartment NA NA Rat Human DTXSID4048802 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048802 TK.Half.Life NA 0.9095 hours 1compartment NA NA Rat Human -DTXSID4048802 Css NA 0.04222 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048802 Css NA 0.2585 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048802 Css NA 0.03514 mg/L PBTK NA 50% Rat Human -DTXSID4048802 Css NA 0.1742 mg/L PBTK NA 95% Rat Human -DTXSID4048804 Clint NA 16.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048804 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048804 Vd NA 2.69 L/kg 1compartment NA NA Human Human -DTXSID4048804 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID4048804 TK.Half.Life NA 71.72 hours 1compartment NA NA Human Human -DTXSID4048804 Css NA 3.793 mg/L 3compartmentss NA 50% Human Human -DTXSID4048804 Css NA 26.56 mg/L 3compartmentss NA 95% Human Human -DTXSID4048804 Css NA 2.528 mg/L PBTK NA 50% Human Human -DTXSID4048804 Css NA 16.93 mg/L PBTK NA 95% Human Human -DTXSID4048804 Clint NA 16.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048804 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048804 Vd NA 2.008 L/kg 1compartment NA NA Rat Human -DTXSID4048804 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID4048804 TK.Half.Life NA 15.14 hours 1compartment NA NA Rat Human -DTXSID4048804 Css NA 2.104 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048804 Css NA 12.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048804 Css NA 1.332 mg/L PBTK NA 50% Rat Human -DTXSID4048804 Css NA 7.569 mg/L PBTK NA 95% Rat Human -DTXSID4048806 Clint NA 53.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048806 Fup NA 0.2224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048806 Vd NA 3.043 L/kg 1compartment NA NA Human Human +DTXSID4048802 TK.Half.Life NA 1.247 hours 1compartment NA NA Rat Human +DTXSID4048802 Css NA 0.004723 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048802 Css NA 0.04239 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048802 Css NA 0.00412 mg/L PBTK NA 50% Rat Human +DTXSID4048802 Css NA 0.03003 mg/L PBTK NA 95% Rat Human +DTXSID4048804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048804 Fup 0.00731 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048804 Vd NA 2.812 L/kg 1compartment NA NA Human Human +DTXSID4048804 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID4048804 TK.Half.Life NA 64.48 hours 1compartment NA NA Human Human +DTXSID4048804 Css NA 3.056 mg/L 3compartmentss NA 50% Human Human +DTXSID4048804 Css NA 22.26 mg/L 3compartmentss NA 95% Human Human +DTXSID4048804 Css NA 2.052 mg/L PBTK NA 50% Human Human +DTXSID4048804 Css NA 14.33 mg/L PBTK NA 95% Human Human +DTXSID4048804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048804 Fup 0.00731 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048804 Vd NA 2.1 L/kg 1compartment NA NA Rat Human +DTXSID4048804 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID4048804 TK.Half.Life NA 12.32 hours 1compartment NA NA Rat Human +DTXSID4048804 Css NA 0.399 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048804 Css NA 2.422 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048804 Css NA 0.2645 mg/L PBTK NA 50% Rat Human +DTXSID4048804 Css NA 1.546 mg/L PBTK NA 95% Rat Human +DTXSID4048806 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048806 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048806 Vd NA 2.579 L/kg 1compartment NA NA Human Human DTXSID4048806 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048806 TK.Half.Life NA 2.428 hours 1compartment NA NA Human Human -DTXSID4048806 Css NA 0.02478 mg/L 3compartmentss NA 50% Human Human -DTXSID4048806 Css NA 0.1993 mg/L 3compartmentss NA 95% Human Human -DTXSID4048806 Css NA 0.02556 mg/L PBTK NA 50% Human Human -DTXSID4048806 Css NA 0.1699 mg/L PBTK NA 95% Human Human -DTXSID4048806 Clint NA 53.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048806 Fup NA 0.2224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048806 Vd NA 3.042 L/kg 1compartment NA NA Rat Human +DTXSID4048806 TK.Half.Life NA 4.432 hours 1compartment NA NA Human Human +DTXSID4048806 Css NA 0.1138 mg/L 3compartmentss NA 50% Human Human +DTXSID4048806 Css NA 0.7582 mg/L 3compartmentss NA 95% Human Human +DTXSID4048806 Css NA 0.08785 mg/L PBTK NA 50% Human Human +DTXSID4048806 Css NA 0.5479 mg/L PBTK NA 95% Human Human +DTXSID4048806 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048806 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048806 Vd NA 1.997 L/kg 1compartment NA NA Rat Human DTXSID4048806 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048806 TK.Half.Life NA 1.243 hours 1compartment NA NA Rat Human -DTXSID4048806 Css NA 0.01323 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048806 Css NA 0.08766 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048806 Css NA 0.01351 mg/L PBTK NA 50% Rat Human -DTXSID4048806 Css NA 0.07546 mg/L PBTK NA 95% Rat Human -DTXSID4048808 Clint NA 5.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048808 Fup NA 0.6431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048808 Vd NA 1.842 L/kg 1compartment NA NA Human Human -DTXSID4048808 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048808 TK.Half.Life NA 2.701 hours 1compartment NA NA Human Human -DTXSID4048808 Css NA 0.1088 mg/L 3compartmentss NA 50% Human Human -DTXSID4048808 Css NA 1.029 mg/L 3compartmentss NA 95% Human Human -DTXSID4048808 Css NA 0.1036 mg/L PBTK NA 50% Human Human -DTXSID4048808 Css NA 0.734 mg/L PBTK NA 95% Human Human -DTXSID4048808 Clint NA 5.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048808 Fup NA 0.6431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048808 Vd NA 1.842 L/kg 1compartment NA NA Rat Human +DTXSID4048806 TK.Half.Life NA 1.268 hours 1compartment NA NA Rat Human +DTXSID4048806 Css NA 0.01426 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048806 Css NA 0.07173 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048806 Css NA 0.01104 mg/L PBTK NA 50% Rat Human +DTXSID4048806 Css NA 0.05308 mg/L PBTK NA 95% Rat Human +DTXSID4048808 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048808 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048808 Vd NA 1.149 L/kg 1compartment NA NA Human Human +DTXSID4048808 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4048808 TK.Half.Life NA 12 hours 1compartment NA NA Human Human +DTXSID4048808 Css NA 1.089 mg/L 3compartmentss NA 50% Human Human +DTXSID4048808 Css NA 7.625 mg/L 3compartmentss NA 95% Human Human +DTXSID4048808 Css NA 0.9378 mg/L PBTK NA 50% Human Human +DTXSID4048808 Css NA 4.858 mg/L PBTK NA 95% Human Human +DTXSID4048808 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048808 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048808 Vd NA 1.166 L/kg 1compartment NA NA Rat Human DTXSID4048808 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048808 TK.Half.Life NA 1.475 hours 1compartment NA NA Rat Human -DTXSID4048808 Css NA 0.05036 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048808 Css NA 0.4281 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048808 Css NA 0.04761 mg/L PBTK NA 50% Rat Human -DTXSID4048808 Css NA 0.2749 mg/L PBTK NA 95% Rat Human -DTXSID4048850 Clint NA 13.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048850 Fup NA 0.1296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048850 Vd NA 1.733 L/kg 1compartment NA NA Human Human +DTXSID4048808 TK.Half.Life NA 4.146 hours 1compartment NA NA Rat Human +DTXSID4048808 Css NA 0.06503 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048808 Css NA 0.4582 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048808 Css NA 0.05606 mg/L PBTK NA 50% Rat Human +DTXSID4048808 Css NA 0.2839 mg/L PBTK NA 95% Rat Human +DTXSID4048850 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048850 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048850 Vd NA 3.362 L/kg 1compartment NA NA Human Human DTXSID4048850 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048850 TK.Half.Life NA 4.646 hours 1compartment NA NA Human Human -DTXSID4048850 Css NA 0.2692 mg/L 3compartmentss NA 50% Human Human -DTXSID4048850 Css NA 2.283 mg/L 3compartmentss NA 95% Human Human -DTXSID4048850 Css NA 0.2074 mg/L PBTK NA 50% Human Human -DTXSID4048850 Css NA 1.53 mg/L PBTK NA 95% Human Human -DTXSID4048850 Clint NA 13.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048850 Fup NA 0.1296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048850 Vd NA 1.694 L/kg 1compartment NA NA Rat Human +DTXSID4048850 TK.Half.Life NA 5.449 hours 1compartment NA NA Human Human +DTXSID4048850 Css NA 0.0914 mg/L 3compartmentss NA 50% Human Human +DTXSID4048850 Css NA 0.7749 mg/L 3compartmentss NA 95% Human Human +DTXSID4048850 Css NA 0.1066 mg/L PBTK NA 50% Human Human +DTXSID4048850 Css NA 0.6556 mg/L PBTK NA 95% Human Human +DTXSID4048850 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048850 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048850 Vd NA 3.386 L/kg 1compartment NA NA Rat Human DTXSID4048850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048850 TK.Half.Life NA 2.7 hours 1compartment NA NA Rat Human -DTXSID4048850 Css NA 0.1477 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048850 Css NA 0.9294 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048850 Css NA 0.1087 mg/L PBTK NA 50% Rat Human -DTXSID4048850 Css NA 0.579 mg/L PBTK NA 95% Rat Human -DTXSID4048852 Clint NA 13.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048852 Fup NA 0.0534 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048852 Vd NA 1.126 L/kg 1compartment NA NA Human Human +DTXSID4048850 TK.Half.Life NA 3.074 hours 1compartment NA NA Rat Human +DTXSID4048850 Css NA 0.01036 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048850 Css NA 0.07162 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048850 Css NA 0.01255 mg/L PBTK NA 50% Rat Human +DTXSID4048850 Css NA 0.05994 mg/L PBTK NA 95% Rat Human +DTXSID4048852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048852 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048852 Vd NA 1.437 L/kg 1compartment NA NA Human Human DTXSID4048852 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048852 TK.Half.Life NA 6.736 hours 1compartment NA NA Human Human -DTXSID4048852 Css NA 0.884 mg/L 3compartmentss NA 50% Human Human -DTXSID4048852 Css NA 6.555 mg/L 3compartmentss NA 95% Human Human -DTXSID4048852 Css NA 0.5582 mg/L PBTK NA 50% Human Human -DTXSID4048852 Css NA 4.015 mg/L PBTK NA 95% Human Human -DTXSID4048852 Clint NA 13.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048852 Fup NA 0.0534 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048852 Vd NA 0.8567 L/kg 1compartment NA NA Rat Human +DTXSID4048852 TK.Half.Life NA 4.035 hours 1compartment NA NA Human Human +DTXSID4048852 Css NA 0.3048 mg/L 3compartmentss NA 50% Human Human +DTXSID4048852 Css NA 2.343 mg/L 3compartmentss NA 95% Human Human +DTXSID4048852 Css NA 0.2008 mg/L PBTK NA 50% Human Human +DTXSID4048852 Css NA 1.478 mg/L PBTK NA 95% Human Human +DTXSID4048852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048852 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048852 Vd NA 1.103 L/kg 1compartment NA NA Rat Human DTXSID4048852 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048852 TK.Half.Life NA 2.882 hours 1compartment NA NA Rat Human -DTXSID4048852 Css NA 0.4936 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048852 Css NA 2.785 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048852 Css NA 0.2912 mg/L PBTK NA 50% Rat Human -DTXSID4048852 Css NA 1.57 mg/L PBTK NA 95% Rat Human -DTXSID4048854 Clint NA 0.6453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048854 Fup NA 0.1154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048854 Vd NA 1.303 L/kg 1compartment NA NA Human Human -DTXSID4048854 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID4048854 TK.Half.Life NA 42.01 hours 1compartment NA NA Human Human -DTXSID4048854 Css NA 4.533 mg/L 3compartmentss NA 50% Human Human -DTXSID4048854 Css NA 20.75 mg/L 3compartmentss NA 95% Human Human -DTXSID4048854 Css NA 3.028 mg/L PBTK NA 50% Human Human -DTXSID4048854 Css NA 12.56 mg/L PBTK NA 95% Human Human -DTXSID4048854 Clint NA 0.6453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048854 Fup NA 0.1154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048854 Vd NA 1.008 L/kg 1compartment NA NA Rat Human -DTXSID4048854 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4048854 TK.Half.Life NA 12.92 hours 1compartment NA NA Rat Human -DTXSID4048854 Css NA 1.791 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048854 Css NA 6.747 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048854 Css NA 1.12 mg/L PBTK NA 50% Rat Human -DTXSID4048854 Css NA 3.816 mg/L PBTK NA 95% Rat Human -DTXSID4048856 Clint NA 29.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048856 Fup NA 0.2021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048856 Vd NA 3.517 L/kg 1compartment NA NA Human Human +DTXSID4048852 TK.Half.Life NA 1.59 hours 1compartment NA NA Rat Human +DTXSID4048852 Css NA 0.03877 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048852 Css NA 0.2445 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048852 Css NA 0.0251 mg/L PBTK NA 50% Rat Human +DTXSID4048852 Css NA 0.1513 mg/L PBTK NA 95% Rat Human +DTXSID4048854 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048854 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048854 Vd NA 1.885 L/kg 1compartment NA NA Human Human +DTXSID4048854 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4048854 TK.Half.Life NA 3.105 hours 1compartment NA NA Human Human +DTXSID4048854 Css NA 0.1068 mg/L 3compartmentss NA 50% Human Human +DTXSID4048854 Css NA 0.7283 mg/L 3compartmentss NA 95% Human Human +DTXSID4048854 Css NA 0.07908 mg/L PBTK NA 50% Human Human +DTXSID4048854 Css NA 0.5075 mg/L PBTK NA 95% Human Human +DTXSID4048854 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048854 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048854 Vd NA 1.472 L/kg 1compartment NA NA Rat Human +DTXSID4048854 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4048854 TK.Half.Life NA 1.103 hours 1compartment NA NA Rat Human +DTXSID4048854 Css NA 0.01339 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048854 Css NA 0.06957 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048854 Css NA 0.00993 mg/L PBTK NA 50% Rat Human +DTXSID4048854 Css NA 0.04965 mg/L PBTK NA 95% Rat Human +DTXSID4048856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048856 Fup 0.25 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048856 Vd NA 2.621 L/kg 1compartment NA NA Human Human DTXSID4048856 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048856 TK.Half.Life NA 3.389 hours 1compartment NA NA Human Human -DTXSID4048856 Css NA 0.0395 mg/L 3compartmentss NA 50% Human Human -DTXSID4048856 Css NA 0.3289 mg/L 3compartmentss NA 95% Human Human -DTXSID4048856 Css NA 0.04462 mg/L PBTK NA 50% Human Human -DTXSID4048856 Css NA 0.305 mg/L PBTK NA 95% Human Human -DTXSID4048856 Clint NA 29.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048856 Fup NA 0.2021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048856 Vd NA 3.53 L/kg 1compartment NA NA Rat Human +DTXSID4048856 TK.Half.Life NA 6.377 hours 1compartment NA NA Human Human +DTXSID4048856 Css NA 0.194 mg/L 3compartmentss NA 50% Human Human +DTXSID4048856 Css NA 1.283 mg/L 3compartmentss NA 95% Human Human +DTXSID4048856 Css NA 0.1437 mg/L PBTK NA 50% Human Human +DTXSID4048856 Css NA 0.8956 mg/L PBTK NA 95% Human Human +DTXSID4048856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048856 Fup 0.25 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048856 Vd NA 2.017 L/kg 1compartment NA NA Rat Human DTXSID4048856 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048856 TK.Half.Life NA 1.849 hours 1compartment NA NA Rat Human -DTXSID4048856 Css NA 0.02088 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048856 Css NA 0.1382 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048856 Css NA 0.02349 mg/L PBTK NA 50% Rat Human -DTXSID4048856 Css NA 0.121 mg/L PBTK NA 95% Rat Human -DTXSID4048858 Clint NA 12.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048858 Fup NA 0.583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048858 Vd NA 2.515 L/kg 1compartment NA NA Human Human +DTXSID4048856 TK.Half.Life NA 1.739 hours 1compartment NA NA Rat Human +DTXSID4048856 Css NA 0.02477 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048856 Css NA 0.1194 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048856 Css NA 0.01832 mg/L PBTK NA 50% Rat Human +DTXSID4048856 Css NA 0.08596 mg/L PBTK NA 95% Rat Human +DTXSID4048858 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048858 Fup 0.439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048858 Vd NA 1.142 L/kg 1compartment NA NA Human Human DTXSID4048858 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048858 TK.Half.Life NA 2.177 hours 1compartment NA NA Human Human -DTXSID4048858 Css NA 0.03994 mg/L 3compartmentss NA 50% Human Human -DTXSID4048858 Css NA 0.459 mg/L 3compartmentss NA 95% Human Human -DTXSID4048858 Css NA 0.04592 mg/L PBTK NA 50% Human Human -DTXSID4048858 Css NA 0.3757 mg/L PBTK NA 95% Human Human -DTXSID4048858 Clint NA 12.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048858 Fup NA 0.583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048858 Vd NA 2.482 L/kg 1compartment NA NA Rat Human +DTXSID4048858 TK.Half.Life NA 2.101 hours 1compartment NA NA Human Human +DTXSID4048858 Css NA 0.1347 mg/L 3compartmentss NA 50% Human Human +DTXSID4048858 Css NA 0.9795 mg/L 3compartmentss NA 95% Human Human +DTXSID4048858 Css NA 0.1106 mg/L PBTK NA 50% Human Human +DTXSID4048858 Css NA 0.6741 mg/L PBTK NA 95% Human Human +DTXSID4048858 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048858 Fup 0.439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048858 Vd NA 1.157 L/kg 1compartment NA NA Rat Human DTXSID4048858 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048858 TK.Half.Life NA 1.172 hours 1compartment NA NA Rat Human -DTXSID4048858 Css NA 0.01982 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048858 Css NA 0.2146 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048858 Css NA 0.02297 mg/L PBTK NA 50% Rat Human -DTXSID4048858 Css NA 0.1561 mg/L PBTK NA 95% Rat Human -DTXSID4048931 Clint NA 14.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048931 Fup NA 0.0693 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048931 Vd NA 3.069 L/kg 1compartment NA NA Human Human -DTXSID4048931 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048931 TK.Half.Life NA 9.826 hours 1compartment NA NA Human Human -DTXSID4048931 Css NA 0.2825 mg/L 3compartmentss NA 50% Human Human -DTXSID4048931 Css NA 1.924 mg/L 3compartmentss NA 95% Human Human -DTXSID4048931 Css NA 0.2308 mg/L PBTK NA 50% Human Human -DTXSID4048931 Css NA 1.506 mg/L PBTK NA 95% Human Human -DTXSID4048931 Clint NA 14.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048931 Fup NA 0.0693 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048931 Vd NA 2.65 L/kg 1compartment NA NA Rat Human +DTXSID4048858 TK.Half.Life NA 1.193 hours 1compartment NA NA Rat Human +DTXSID4048858 Css NA 0.01564 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048858 Css NA 0.08587 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048858 Css NA 0.01286 mg/L PBTK NA 50% Rat Human +DTXSID4048858 Css NA 0.05765 mg/L PBTK NA 95% Rat Human +DTXSID4048931 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048931 Fup 0.0529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048931 Vd NA 2.595 L/kg 1compartment NA NA Human Human +DTXSID4048931 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4048931 TK.Half.Life NA 17.18 hours 1compartment NA NA Human Human +DTXSID4048931 Css NA 0.8134 mg/L 3compartmentss NA 50% Human Human +DTXSID4048931 Css NA 5.591 mg/L 3compartmentss NA 95% Human Human +DTXSID4048931 Css NA 0.5586 mg/L PBTK NA 50% Human Human +DTXSID4048931 Css NA 3.671 mg/L PBTK NA 95% Human Human +DTXSID4048931 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048931 Fup 0.0529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048931 Vd NA 1.991 L/kg 1compartment NA NA Rat Human DTXSID4048931 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048931 TK.Half.Life NA 3.612 hours 1compartment NA NA Rat Human -DTXSID4048931 Css NA 0.1554 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048931 Css NA 0.8506 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048931 Css NA 0.1226 mg/L PBTK NA 50% Rat Human -DTXSID4048931 Css NA 0.6162 mg/L PBTK NA 95% Rat Human -DTXSID4048933 Clint NA 11.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048933 Fup NA 0.0848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048933 Vd NA 2.669 L/kg 1compartment NA NA Human Human -DTXSID4048933 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4048933 TK.Half.Life NA 15.96 hours 1compartment NA NA Human Human -DTXSID4048933 Css NA 0.719 mg/L 3compartmentss NA 50% Human Human -DTXSID4048933 Css NA 4.859 mg/L 3compartmentss NA 95% Human Human -DTXSID4048933 Css NA 0.5231 mg/L PBTK NA 50% Human Human -DTXSID4048933 Css NA 3.306 mg/L PBTK NA 95% Human Human -DTXSID4048933 Clint NA 11.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048933 Fup NA 0.0848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048933 Vd NA 2.146 L/kg 1compartment NA NA Rat Human +DTXSID4048931 TK.Half.Life NA 4.581 hours 1compartment NA NA Rat Human +DTXSID4048931 Css NA 0.1054 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048931 Css NA 0.575 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048931 Css NA 0.07142 mg/L PBTK NA 50% Rat Human +DTXSID4048931 Css NA 0.3723 mg/L PBTK NA 95% Rat Human +DTXSID4048933 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048933 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048933 Vd NA 1.912 L/kg 1compartment NA NA Human Human +DTXSID4048933 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4048933 TK.Half.Life NA 4.092 hours 1compartment NA NA Human Human +DTXSID4048933 Css NA 0.1904 mg/L 3compartmentss NA 50% Human Human +DTXSID4048933 Css NA 1.62 mg/L 3compartmentss NA 95% Human Human +DTXSID4048933 Css NA 0.1414 mg/L PBTK NA 50% Human Human +DTXSID4048933 Css NA 1.101 mg/L PBTK NA 95% Human Human +DTXSID4048933 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048933 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048933 Vd NA 1.693 L/kg 1compartment NA NA Rat Human DTXSID4048933 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048933 TK.Half.Life NA 4.93 hours 1compartment NA NA Rat Human -DTXSID4048933 Css NA 0.3898 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048933 Css NA 2.039 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048933 Css NA 0.271 mg/L PBTK NA 50% Rat Human -DTXSID4048933 Css NA 1.308 mg/L PBTK NA 95% Rat Human -DTXSID4048935 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048935 Fup NA 0.0933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048935 Vd NA 3.012 L/kg 1compartment NA NA Human Human -DTXSID4048935 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4048935 TK.Half.Life NA 37.77 hours 1compartment NA NA Human Human -DTXSID4048935 Css NA 1.513 mg/L 3compartmentss NA 50% Human Human -DTXSID4048935 Css NA 9.238 mg/L 3compartmentss NA 95% Human Human -DTXSID4048935 Css NA 1.051 mg/L PBTK NA 50% Human Human -DTXSID4048935 Css NA 6.409 mg/L PBTK NA 95% Human Human -DTXSID4048935 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048935 Fup NA 0.0933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048935 Vd NA 2.261 L/kg 1compartment NA NA Rat Human -DTXSID4048935 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4048935 TK.Half.Life NA 6.139 hours 1compartment NA NA Rat Human -DTXSID4048935 Css NA 0.8342 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048935 Css NA 4.114 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048935 Css NA 0.556 mg/L PBTK NA 50% Rat Human -DTXSID4048935 Css NA 2.658 mg/L PBTK NA 95% Rat Human -DTXSID4048937 Clint NA 12.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048937 Fup NA 0.0797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048937 Vd NA 2.563 L/kg 1compartment NA NA Human Human -DTXSID4048937 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4048937 TK.Half.Life NA 23.19 hours 1compartment NA NA Human Human -DTXSID4048937 Css NA 1.158 mg/L 3compartmentss NA 50% Human Human -DTXSID4048937 Css NA 7.293 mg/L 3compartmentss NA 95% Human Human -DTXSID4048937 Css NA 0.7953 mg/L PBTK NA 50% Human Human -DTXSID4048937 Css NA 4.754 mg/L PBTK NA 95% Human Human -DTXSID4048937 Clint NA 12.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048937 Fup NA 0.0797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048937 Vd NA 1.928 L/kg 1compartment NA NA Rat Human -DTXSID4048937 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4048937 TK.Half.Life NA 5.581 hours 1compartment NA NA Rat Human -DTXSID4048937 Css NA 0.639 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048937 Css NA 2.954 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048937 Css NA 0.4158 mg/L PBTK NA 50% Rat Human -DTXSID4048937 Css NA 1.891 mg/L PBTK NA 95% Rat Human -DTXSID4048939 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048939 Fup NA 0.5138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048939 Vd NA 1.721 L/kg 1compartment NA NA Human Human +DTXSID4048933 TK.Half.Life NA 1.928 hours 1compartment NA NA Rat Human +DTXSID4048933 Css NA 0.02432 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048933 Css NA 0.1573 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048933 Css NA 0.01786 mg/L PBTK NA 50% Rat Human +DTXSID4048933 Css NA 0.1039 mg/L PBTK NA 95% Rat Human +DTXSID4048935 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048935 Fup 0.0785 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048935 Vd NA 2.198 L/kg 1compartment NA NA Human Human +DTXSID4048935 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4048935 TK.Half.Life NA 9.469 hours 1compartment NA NA Human Human +DTXSID4048935 Css NA 0.5044 mg/L 3compartmentss NA 50% Human Human +DTXSID4048935 Css NA 3.459 mg/L 3compartmentss NA 95% Human Human +DTXSID4048935 Css NA 0.3372 mg/L PBTK NA 50% Human Human +DTXSID4048935 Css NA 2.226 mg/L PBTK NA 95% Human Human +DTXSID4048935 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048935 Fup 0.0785 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048935 Vd NA 1.654 L/kg 1compartment NA NA Rat Human +DTXSID4048935 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4048935 TK.Half.Life NA 2.874 hours 1compartment NA NA Rat Human +DTXSID4048935 Css NA 0.06523 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048935 Css NA 0.3494 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048935 Css NA 0.04328 mg/L PBTK NA 50% Rat Human +DTXSID4048935 Css NA 0.2215 mg/L PBTK NA 95% Rat Human +DTXSID4048937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048937 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048937 Vd NA 2.419 L/kg 1compartment NA NA Human Human +DTXSID4048937 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4048937 TK.Half.Life NA 8.187 hours 1compartment NA NA Human Human +DTXSID4048937 Css NA 0.3492 mg/L 3compartmentss NA 50% Human Human +DTXSID4048937 Css NA 2.345 mg/L 3compartmentss NA 95% Human Human +DTXSID4048937 Css NA 0.2411 mg/L PBTK NA 50% Human Human +DTXSID4048937 Css NA 1.529 mg/L PBTK NA 95% Human Human +DTXSID4048937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048937 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048937 Vd NA 1.831 L/kg 1compartment NA NA Rat Human +DTXSID4048937 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4048937 TK.Half.Life NA 2.294 hours 1compartment NA NA Rat Human +DTXSID4048937 Css NA 0.04446 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048937 Css NA 0.2342 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048937 Css NA 0.03063 mg/L PBTK NA 50% Rat Human +DTXSID4048937 Css NA 0.1543 mg/L PBTK NA 95% Rat Human +DTXSID4048939 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048939 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048939 Vd NA 0.6662 L/kg 1compartment NA NA Human Human DTXSID4048939 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048939 TK.Half.Life NA 2.035 hours 1compartment NA NA Human Human -DTXSID4048939 Css NA 0.06545 mg/L 3compartmentss NA 50% Human Human -DTXSID4048939 Css NA 0.5071 mg/L 3compartmentss NA 95% Human Human -DTXSID4048939 Css NA 0.05446 mg/L PBTK NA 50% Human Human -DTXSID4048939 Css NA 0.368 mg/L PBTK NA 95% Human Human -DTXSID4048939 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048939 Fup NA 0.5138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048939 Vd NA 1.427 L/kg 1compartment NA NA Rat Human +DTXSID4048939 TK.Half.Life NA 1.17 hours 1compartment NA NA Human Human +DTXSID4048939 Css NA 0.1335 mg/L 3compartmentss NA 50% Human Human +DTXSID4048939 Css NA 0.9859 mg/L 3compartmentss NA 95% Human Human +DTXSID4048939 Css NA 0.1025 mg/L PBTK NA 50% Human Human +DTXSID4048939 Css NA 0.6551 mg/L PBTK NA 95% Human Human +DTXSID4048939 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048939 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048939 Vd NA 0.6614 L/kg 1compartment NA NA Rat Human DTXSID4048939 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048939 TK.Half.Life NA 0.7996 hours 1compartment NA NA Rat Human -DTXSID4048939 Css NA 0.03416 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048939 Css NA 0.212 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048939 Css NA 0.02784 mg/L PBTK NA 50% Rat Human -DTXSID4048939 Css NA 0.1452 mg/L PBTK NA 95% Rat Human +DTXSID4048939 TK.Half.Life NA 0.6377 hours 1compartment NA NA Rat Human +DTXSID4048939 Css NA 0.01527 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048939 Css NA 0.0911 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048939 Css NA 0.0118 mg/L PBTK NA 50% Rat Human +DTXSID4048939 Css NA 0.05843 mg/L PBTK NA 95% Rat Human DTXSID4048981 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4048981 Fup NA 0.3182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048981 Vd NA 0.3272 L/kg 1compartment NA NA Human Human +DTXSID4048981 Vd NA 0.3838 L/kg 1compartment NA NA Human Human DTXSID4048981 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048981 TK.Half.Life NA 6.652 hours 1compartment NA NA Human Human -DTXSID4048981 Css NA 2.508 mg/L 3compartmentss NA 50% Human Human -DTXSID4048981 Css NA 9.628 mg/L 3compartmentss NA 95% Human Human -DTXSID4048981 Css NA 1.677 mg/L PBTK NA 50% Human Human -DTXSID4048981 Css NA 5.872 mg/L PBTK NA 95% Human Human +DTXSID4048981 TK.Half.Life NA 7.804 hours 1compartment NA NA Human Human +DTXSID4048981 Css NA 1.294 mg/L 3compartmentss NA 50% Human Human +DTXSID4048981 Css NA 5.415 mg/L 3compartmentss NA 95% Human Human +DTXSID4048981 Css NA 0.8924 mg/L PBTK NA 50% Human Human +DTXSID4048981 Css NA 3.343 mg/L PBTK NA 95% Human Human DTXSID4048981 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4048981 Fup NA 0.3182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048981 Vd NA 0.342 L/kg 1compartment NA NA Rat Human +DTXSID4048981 Vd NA 0.3915 L/kg 1compartment NA NA Rat Human DTXSID4048981 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048981 TK.Half.Life NA 2.371 hours 1compartment NA NA Rat Human -DTXSID4048981 Css NA 0.693 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048981 Css NA 2.254 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048981 Css NA 0.4383 mg/L PBTK NA 50% Rat Human -DTXSID4048981 Css NA 1.288 mg/L PBTK NA 95% Rat Human -DTXSID4048983 Clint NA 318.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048983 Fup NA 0.0595 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048983 Vd NA 0.281 L/kg 1compartment NA NA Human Human +DTXSID4048981 TK.Half.Life NA 2.714 hours 1compartment NA NA Rat Human +DTXSID4048981 Css NA 0.007066 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048981 Css NA 0.03025 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048981 Css NA 0.004639 mg/L PBTK NA 50% Rat Human +DTXSID4048981 Css NA 0.01783 mg/L PBTK NA 95% Rat Human +DTXSID4048983 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048983 Fup 0.0897 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048983 Vd NA 0.4128 L/kg 1compartment NA NA Human Human DTXSID4048983 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048983 TK.Half.Life NA 0.3158 hours 1compartment NA NA Human Human -DTXSID4048983 Css NA 0.03706 mg/L 3compartmentss NA 50% Human Human -DTXSID4048983 Css NA 0.3243 mg/L 3compartmentss NA 95% Human Human -DTXSID4048983 Css NA 0.02268 mg/L PBTK NA 50% Human Human -DTXSID4048983 Css NA 0.1947 mg/L PBTK NA 95% Human Human -DTXSID4048983 Clint NA 318.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048983 Fup NA 0.0595 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048983 Vd NA 0.2719 L/kg 1compartment NA NA Rat Human +DTXSID4048983 TK.Half.Life NA 1.135 hours 1compartment NA NA Human Human +DTXSID4048983 Css NA 0.27 mg/L 3compartmentss NA 50% Human Human +DTXSID4048983 Css NA 2.33 mg/L 3compartmentss NA 95% Human Human +DTXSID4048983 Css NA 0.1749 mg/L PBTK NA 50% Human Human +DTXSID4048983 Css NA 1.424 mg/L PBTK NA 95% Human Human +DTXSID4048983 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048983 Fup 0.0897 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048983 Vd NA 0.3896 L/kg 1compartment NA NA Rat Human DTXSID4048983 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048983 TK.Half.Life NA 0.1479 hours 1compartment NA NA Rat Human -DTXSID4048983 Css NA 0.02146 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048983 Css NA 0.1545 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048983 Css NA 0.0123 mg/L PBTK NA 50% Rat Human -DTXSID4048983 Css NA 0.08636 mg/L PBTK NA 95% Rat Human -DTXSID4048985 Clint NA 3.171 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048985 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048985 Vd NA 2.972 L/kg 1compartment NA NA Human Human -DTXSID4048985 Days.Css NA 85 Days PBTK NA NA Human Human -DTXSID4048985 TK.Half.Life NA 375.7 hours 1compartment NA NA Human Human -DTXSID4048985 Css NA 16.72 mg/L 3compartmentss NA 50% Human Human -DTXSID4048985 Css NA 100.6 mg/L 3compartmentss NA 95% Human Human -DTXSID4048985 Css NA 11.4 mg/L PBTK NA 50% Human Human -DTXSID4048985 Css NA 66.83 mg/L PBTK NA 95% Human Human -DTXSID4048985 Clint NA 3.171 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048985 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048985 Vd NA 2.225 L/kg 1compartment NA NA Rat Human -DTXSID4048985 Days.Css NA 45 Days PBTK NA NA Rat Human -DTXSID4048985 TK.Half.Life NA 57.86 hours 1compartment NA NA Rat Human -DTXSID4048985 Css NA 9.106 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048985 Css NA 40.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048985 Css NA 5.956 mg/L PBTK NA 50% Rat Human -DTXSID4048985 Css NA 25.67 mg/L PBTK NA 95% Rat Human -DTXSID4048987 Clint NA 51.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048987 Fup NA 0.3829 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4048987 Vd NA 0.8739 L/kg 1compartment NA NA Human Human +DTXSID4048983 TK.Half.Life NA 0.6436 hours 1compartment NA NA Rat Human +DTXSID4048983 Css NA 0.013 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048983 Css NA 0.1241 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048983 Css NA 0.008115 mg/L PBTK NA 50% Rat Human +DTXSID4048983 Css NA 0.07345 mg/L PBTK NA 95% Rat Human +DTXSID4048985 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048985 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048985 Vd NA 2.529 L/kg 1compartment NA NA Human Human +DTXSID4048985 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID4048985 TK.Half.Life NA 37.71 hours 1compartment NA NA Human Human +DTXSID4048985 Css NA 2.069 mg/L 3compartmentss NA 50% Human Human +DTXSID4048985 Css NA 15.47 mg/L 3compartmentss NA 95% Human Human +DTXSID4048985 Css NA 1.366 mg/L PBTK NA 50% Human Human +DTXSID4048985 Css NA 9.821 mg/L PBTK NA 95% Human Human +DTXSID4048985 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048985 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048985 Vd NA 1.885 L/kg 1compartment NA NA Rat Human +DTXSID4048985 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4048985 TK.Half.Life NA 9.093 hours 1compartment NA NA Rat Human +DTXSID4048985 Css NA 0.2703 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048985 Css NA 1.64 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048985 Css NA 0.1749 mg/L PBTK NA 50% Rat Human +DTXSID4048985 Css NA 1.024 mg/L PBTK NA 95% Rat Human +DTXSID4048987 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048987 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4048987 Vd NA 0.8425 L/kg 1compartment NA NA Human Human DTXSID4048987 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4048987 TK.Half.Life NA 0.7813 hours 1compartment NA NA Human Human -DTXSID4048987 Css NA 0.02353 mg/L 3compartmentss NA 50% Human Human -DTXSID4048987 Css NA 0.1854 mg/L 3compartmentss NA 95% Human Human -DTXSID4048987 Css NA 0.01799 mg/L PBTK NA 50% Human Human -DTXSID4048987 Css NA 0.1277 mg/L PBTK NA 95% Human Human -DTXSID4048987 Clint NA 51.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048987 Fup NA 0.3829 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4048987 Vd NA 0.7893 L/kg 1compartment NA NA Rat Human +DTXSID4048987 TK.Half.Life NA 0.9345 hours 1compartment NA NA Human Human +DTXSID4048987 Css NA 0.04804 mg/L 3compartmentss NA 50% Human Human +DTXSID4048987 Css NA 0.3856 mg/L 3compartmentss NA 95% Human Human +DTXSID4048987 Css NA 0.03663 mg/L PBTK NA 50% Human Human +DTXSID4048987 Css NA 0.2634 mg/L PBTK NA 95% Human Human +DTXSID4048987 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048987 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4048987 Vd NA 0.7722 L/kg 1compartment NA NA Rat Human DTXSID4048987 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4048987 TK.Half.Life NA 0.3378 hours 1compartment NA NA Rat Human -DTXSID4048987 Css NA 0.01268 mg/L 3compartmentss NA 50% Rat Human -DTXSID4048987 Css NA 0.08439 mg/L 3compartmentss NA 95% Rat Human -DTXSID4048987 Css NA 0.009292 mg/L PBTK NA 50% Rat Human -DTXSID4048987 Css NA 0.05607 mg/L PBTK NA 95% Rat Human +DTXSID4048987 TK.Half.Life NA 0.4376 hours 1compartment NA NA Rat Human +DTXSID4048987 Css NA 0.005944 mg/L 3compartmentss NA 50% Rat Human +DTXSID4048987 Css NA 0.03798 mg/L 3compartmentss NA 95% Rat Human +DTXSID4048987 Css NA 0.004574 mg/L PBTK NA 50% Rat Human +DTXSID4048987 Css NA 0.02536 mg/L PBTK NA 95% Rat Human DTXSID4049030 Clint NA 0.01519 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4049030 Fup NA 0.5361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049030 Vd NA 0.3599 L/kg 1compartment NA NA Human Human +DTXSID4049030 Vd NA 0.332 L/kg 1compartment NA NA Human Human DTXSID4049030 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049030 TK.Half.Life NA 4.229 hours 1compartment NA NA Human Human -DTXSID4049030 Css NA 1.474 mg/L 3compartmentss NA 50% Human Human -DTXSID4049030 Css NA 7.782 mg/L 3compartmentss NA 95% Human Human -DTXSID4049030 Css NA 1.021 mg/L PBTK NA 50% Human Human -DTXSID4049030 Css NA 4.707 mg/L PBTK NA 95% Human Human +DTXSID4049030 TK.Half.Life NA 3.806 hours 1compartment NA NA Human Human +DTXSID4049030 Css NA 1.214 mg/L 3compartmentss NA 50% Human Human +DTXSID4049030 Css NA 6.596 mg/L 3compartmentss NA 95% Human Human +DTXSID4049030 Css NA 0.8356 mg/L PBTK NA 50% Human Human +DTXSID4049030 Css NA 3.919 mg/L PBTK NA 95% Human Human DTXSID4049030 Clint NA 0.01519 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4049030 Fup NA 0.5361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049030 Vd NA 0.3765 L/kg 1compartment NA NA Rat Human +DTXSID4049030 Vd NA 0.3533 L/kg 1compartment NA NA Rat Human DTXSID4049030 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049030 TK.Half.Life NA 1.528 hours 1compartment NA NA Rat Human -DTXSID4049030 Css NA 0.4066 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049030 Css NA 2.065 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049030 Css NA 0.268 mg/L PBTK NA 50% Rat Human -DTXSID4049030 Css NA 1.172 mg/L PBTK NA 95% Rat Human -DTXSID4049032 Clint NA 0.02321 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049032 Fup NA 0.1482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049032 Vd NA 0.4963 L/kg 1compartment NA NA Human Human -DTXSID4049032 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4049032 TK.Half.Life NA 20.86 hours 1compartment NA NA Human Human -DTXSID4049032 Css NA 5.566 mg/L 3compartmentss NA 50% Human Human -DTXSID4049032 Css NA 27.45 mg/L 3compartmentss NA 95% Human Human -DTXSID4049032 Css NA 3.776 mg/L PBTK NA 50% Human Human -DTXSID4049032 Css NA 16.71 mg/L PBTK NA 95% Human Human -DTXSID4049032 Clint NA 0.02321 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049032 Fup NA 0.1482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049032 Vd NA 0.4915 L/kg 1compartment NA NA Rat Human +DTXSID4049030 TK.Half.Life NA 1.416 hours 1compartment NA NA Rat Human +DTXSID4049030 Css NA 0.02429 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049030 Css NA 0.1752 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049030 Css NA 0.01588 mg/L PBTK NA 50% Rat Human +DTXSID4049030 Css NA 0.1044 mg/L PBTK NA 95% Rat Human +DTXSID4049032 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049032 Fup 0.0868 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049032 Vd NA 0.3791 L/kg 1compartment NA NA Human Human +DTXSID4049032 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4049032 TK.Half.Life NA 2.768 hours 1compartment NA NA Human Human +DTXSID4049032 Css NA 1.062 mg/L 3compartmentss NA 50% Human Human +DTXSID4049032 Css NA 7.399 mg/L 3compartmentss NA 95% Human Human +DTXSID4049032 Css NA 0.6736 mg/L PBTK NA 50% Human Human +DTXSID4049032 Css NA 4.441 mg/L PBTK NA 95% Human Human +DTXSID4049032 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049032 Fup 0.0868 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049032 Vd NA 0.3737 L/kg 1compartment NA NA Rat Human DTXSID4049032 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049032 TK.Half.Life NA 7.178 hours 1compartment NA NA Rat Human -DTXSID4049032 Css NA 1.616 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049032 Css NA 6.573 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049032 Css NA 1.036 mg/L PBTK NA 50% Rat Human -DTXSID4049032 Css NA 3.735 mg/L PBTK NA 95% Rat Human -DTXSID4049034 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049034 Fup NA 0.6036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049034 Vd NA 0.6027 L/kg 1compartment NA NA Human Human +DTXSID4049032 TK.Half.Life NA 1.677 hours 1compartment NA NA Rat Human +DTXSID4049032 Css NA 0.1308 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049032 Css NA 0.6844 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049032 Css NA 0.08062 mg/L PBTK NA 50% Rat Human +DTXSID4049032 Css NA 0.3986 mg/L PBTK NA 95% Rat Human +DTXSID4049034 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049034 Fup 0.651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049034 Vd NA 0.6304 L/kg 1compartment NA NA Human Human DTXSID4049034 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049034 TK.Half.Life NA 6.466 hours 1compartment NA NA Human Human -DTXSID4049034 Css NA 1.265 mg/L 3compartmentss NA 50% Human Human -DTXSID4049034 Css NA 8.424 mg/L 3compartmentss NA 95% Human Human -DTXSID4049034 Css NA 0.9794 mg/L PBTK NA 50% Human Human -DTXSID4049034 Css NA 5.281 mg/L PBTK NA 95% Human Human -DTXSID4049034 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049034 Fup NA 0.6036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049034 Vd NA 0.6239 L/kg 1compartment NA NA Rat Human +DTXSID4049034 TK.Half.Life NA 6.273 hours 1compartment NA NA Human Human +DTXSID4049034 Css NA 0.6365 mg/L 3compartmentss NA 50% Human Human +DTXSID4049034 Css NA 4.295 mg/L 3compartmentss NA 95% Human Human +DTXSID4049034 Css NA 0.506 mg/L PBTK NA 50% Human Human +DTXSID4049034 Css NA 2.707 mg/L PBTK NA 95% Human Human +DTXSID4049034 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049034 Fup 0.651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049034 Vd NA 0.6531 L/kg 1compartment NA NA Rat Human DTXSID4049034 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049034 TK.Half.Life NA 2.279 hours 1compartment NA NA Rat Human -DTXSID4049034 Css NA 0.334 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049034 Css NA 2.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049034 Css NA 0.2486 mg/L PBTK NA 50% Rat Human -DTXSID4049034 Css NA 1.194 mg/L PBTK NA 95% Rat Human -DTXSID4049036 Clint NA 5.254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049036 Fup NA 0.2005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049036 Vd NA 3.625 L/kg 1compartment NA NA Human Human +DTXSID4049034 TK.Half.Life NA 2.212 hours 1compartment NA NA Rat Human +DTXSID4049034 Css NA 0.003346 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049034 Css NA 0.02272 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049034 Css NA 0.00255 mg/L PBTK NA 50% Rat Human +DTXSID4049034 Css NA 0.01378 mg/L PBTK NA 95% Rat Human +DTXSID4049036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049036 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049036 Vd NA 5.596 L/kg 1compartment NA NA Human Human DTXSID4049036 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049036 TK.Half.Life NA 10.68 hours 1compartment NA NA Human Human -DTXSID4049036 Css NA 0.1942 mg/L 3compartmentss NA 50% Human Human -DTXSID4049036 Css NA 1.307 mg/L 3compartmentss NA 95% Human Human -DTXSID4049036 Css NA 0.224 mg/L PBTK NA 50% Human Human -DTXSID4049036 Css NA 1.197 mg/L PBTK NA 95% Human Human -DTXSID4049036 Clint NA 5.254 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049036 Fup NA 0.2005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049036 Vd NA 3.64 L/kg 1compartment NA NA Rat Human +DTXSID4049036 TK.Half.Life NA 3.691 hours 1compartment NA NA Human Human +DTXSID4049036 Css NA 0.01848 mg/L 3compartmentss NA 50% Human Human +DTXSID4049036 Css NA 0.1882 mg/L 3compartmentss NA 95% Human Human +DTXSID4049036 Css NA 0.02947 mg/L PBTK NA 50% Human Human +DTXSID4049036 Css NA 0.2163 mg/L PBTK NA 95% Human Human +DTXSID4049036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049036 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049036 Vd NA 5.689 L/kg 1compartment NA NA Rat Human DTXSID4049036 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049036 TK.Half.Life NA 6.25 hours 1compartment NA NA Rat Human -DTXSID4049036 Css NA 0.09588 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049036 Css NA 0.5193 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049036 Css NA 0.1108 mg/L PBTK NA 50% Rat Human -DTXSID4049036 Css NA 0.4429 mg/L PBTK NA 95% Rat Human +DTXSID4049036 TK.Half.Life NA 1.984 hours 1compartment NA NA Rat Human +DTXSID4049036 Css NA 0.002158 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049036 Css NA 0.01758 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049036 Css NA 0.003694 mg/L PBTK NA 50% Rat Human +DTXSID4049036 Css NA 0.0205 mg/L PBTK NA 95% Rat Human DTXSID4049038 Clint NA 1.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4049038 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049038 Vd NA 0.8348 L/kg 1compartment NA NA Human Human +DTXSID4049038 Vd NA 0.942 L/kg 1compartment NA NA Human Human DTXSID4049038 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049038 TK.Half.Life NA 2.15 hours 1compartment NA NA Human Human -DTXSID4049038 Css NA 0.3118 mg/L 3compartmentss NA 50% Human Human -DTXSID4049038 Css NA 2.094 mg/L 3compartmentss NA 95% Human Human -DTXSID4049038 Css NA 0.2539 mg/L PBTK NA 50% Human Human -DTXSID4049038 Css NA 1.365 mg/L PBTK NA 95% Human Human +DTXSID4049038 TK.Half.Life NA 2.428 hours 1compartment NA NA Human Human +DTXSID4049038 Css NA 0.253 mg/L 3compartmentss NA 50% Human Human +DTXSID4049038 Css NA 1.791 mg/L 3compartmentss NA 95% Human Human +DTXSID4049038 Css NA 0.2114 mg/L PBTK NA 50% Human Human +DTXSID4049038 Css NA 1.192 mg/L PBTK NA 95% Human Human DTXSID4049038 Clint NA 1.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4049038 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049038 Vd NA 0.8576 L/kg 1compartment NA NA Rat Human +DTXSID4049038 Vd NA 0.9562 L/kg 1compartment NA NA Rat Human DTXSID4049038 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049038 TK.Half.Life NA 1.064 hours 1compartment NA NA Rat Human -DTXSID4049038 Css NA 0.1173 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049038 Css NA 0.7504 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049038 Css NA 0.09462 mg/L PBTK NA 50% Rat Human -DTXSID4049038 Css NA 0.4445 mg/L PBTK NA 95% Rat Human -DTXSID4049080 Clint NA 7.312 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049080 Fup NA 0.4048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049080 Vd NA 2.156 L/kg 1compartment NA NA Human Human +DTXSID4049038 TK.Half.Life NA 1.186 hours 1compartment NA NA Rat Human +DTXSID4049038 Css NA 0.006777 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049038 Css NA 0.05452 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049038 Css NA 0.005536 mg/L PBTK NA 50% Rat Human +DTXSID4049038 Css NA 0.03721 mg/L PBTK NA 95% Rat Human +DTXSID4049080 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049080 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049080 Vd NA 1.286 L/kg 1compartment NA NA Human Human DTXSID4049080 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049080 TK.Half.Life NA 3.64 hours 1compartment NA NA Human Human -DTXSID4049080 Css NA 0.1108 mg/L 3compartmentss NA 50% Human Human -DTXSID4049080 Css NA 0.8599 mg/L 3compartmentss NA 95% Human Human -DTXSID4049080 Css NA 0.1065 mg/L PBTK NA 50% Human Human -DTXSID4049080 Css NA 0.6577 mg/L PBTK NA 95% Human Human -DTXSID4049080 Clint NA 7.312 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049080 Fup NA 0.4048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049080 Vd NA 2.158 L/kg 1compartment NA NA Rat Human +DTXSID4049080 TK.Half.Life NA 2.051 hours 1compartment NA NA Human Human +DTXSID4049080 Css NA 0.1144 mg/L 3compartmentss NA 50% Human Human +DTXSID4049080 Css NA 1.016 mg/L 3compartmentss NA 95% Human Human +DTXSID4049080 Css NA 0.09682 mg/L PBTK NA 50% Human Human +DTXSID4049080 Css NA 0.7036 mg/L PBTK NA 95% Human Human +DTXSID4049080 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049080 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049080 Vd NA 1.135 L/kg 1compartment NA NA Rat Human DTXSID4049080 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049080 TK.Half.Life NA 2.056 hours 1compartment NA NA Rat Human -DTXSID4049080 Css NA 0.05565 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049080 Css NA 0.3295 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049080 Css NA 0.0525 mg/L PBTK NA 50% Rat Human -DTXSID4049080 Css NA 0.2397 mg/L PBTK NA 95% Rat Human +DTXSID4049080 TK.Half.Life NA 0.9381 hours 1compartment NA NA Rat Human +DTXSID4049080 Css NA 0.01311 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049080 Css NA 0.09915 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049080 Css NA 0.01127 mg/L PBTK NA 50% Rat Human +DTXSID4049080 Css NA 0.06434 mg/L PBTK NA 95% Rat Human DTXSID4049082 Clint 3.349 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID4049082 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4049082 Vd NA 0.9572 L/kg 1compartment NA NA Human Human -DTXSID4049082 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4049082 TK.Half.Life NA 16.09 hours 1compartment NA NA Human Human -DTXSID4049082 Css NA 2.17 mg/L 3compartmentss NA 50% Human Human -DTXSID4049082 Css NA 13.84 mg/L 3compartmentss NA 95% Human Human -DTXSID4049082 Css NA 1.499 mg/L PBTK NA 50% Human Human -DTXSID4049082 Css NA 8.628 mg/L PBTK NA 95% Human Human +DTXSID4049082 Vd NA 0.5287 L/kg 1compartment NA NA Human Human +DTXSID4049082 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4049082 TK.Half.Life NA 8.912 hours 1compartment NA NA Human Human +DTXSID4049082 Css NA 2.428 mg/L 3compartmentss NA 50% Human Human +DTXSID4049082 Css NA 14.44 mg/L 3compartmentss NA 95% Human Human +DTXSID4049082 Css NA 1.698 mg/L PBTK NA 50% Human Human +DTXSID4049082 Css NA 10.11 mg/L PBTK NA 95% Human Human DTXSID4049082 Clint 8.542 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID4049082 Fup 0.33 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID4049082 Vd NA 2.286 L/kg 1compartment NA NA Rat Rat +DTXSID4049082 Vd NA 1.44 L/kg 1compartment NA NA Rat Rat DTXSID4049082 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID4049082 TK.Half.Life NA 2.536 hours 1compartment NA NA Rat Rat -DTXSID4049082 Css NA 0.1066 mg/L 3compartmentss NA 50% Rat Rat -DTXSID4049082 Css NA 0.4731 mg/L 3compartmentss NA 95% Rat Rat -DTXSID4049082 Css NA 0.0691 mg/L PBTK NA 50% Rat Rat -DTXSID4049082 Css NA 0.2897 mg/L PBTK NA 95% Rat Rat -DTXSID4049240 Clint NA 27.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049240 Fup NA 0.4934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049240 Vd NA 1.685 L/kg 1compartment NA NA Human Human +DTXSID4049082 TK.Half.Life NA 1.579 hours 1compartment NA NA Rat Rat +DTXSID4049082 Css NA 0.01828 mg/L 3compartmentss NA 50% Rat Rat +DTXSID4049082 Css NA 0.08245 mg/L 3compartmentss NA 95% Rat Rat +DTXSID4049082 Css NA 0.01325 mg/L PBTK NA 50% Rat Rat +DTXSID4049082 Css NA 0.05978 mg/L PBTK NA 95% Rat Rat +DTXSID4049240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049240 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049240 Vd NA 1.94 L/kg 1compartment NA NA Human Human DTXSID4049240 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049240 TK.Half.Life NA 1.62 hours 1compartment NA NA Human Human -DTXSID4049240 Css NA 0.03808 mg/L 3compartmentss NA 50% Human Human -DTXSID4049240 Css NA 0.3122 mg/L 3compartmentss NA 95% Human Human -DTXSID4049240 Css NA 0.03144 mg/L PBTK NA 50% Human Human -DTXSID4049240 Css NA 0.2286 mg/L PBTK NA 95% Human Human -DTXSID4049240 Clint NA 27.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049240 Fup NA 0.4934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049240 Vd NA 1.395 L/kg 1compartment NA NA Rat Human +DTXSID4049240 TK.Half.Life NA 2.442 hours 1compartment NA NA Human Human +DTXSID4049240 Css NA 0.06471 mg/L 3compartmentss NA 50% Human Human +DTXSID4049240 Css NA 0.4869 mg/L 3compartmentss NA 95% Human Human +DTXSID4049240 Css NA 0.05134 mg/L PBTK NA 50% Human Human +DTXSID4049240 Css NA 0.3582 mg/L PBTK NA 95% Human Human +DTXSID4049240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049240 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049240 Vd NA 1.553 L/kg 1compartment NA NA Rat Human DTXSID4049240 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049240 TK.Half.Life NA 0.6245 hours 1compartment NA NA Rat Human -DTXSID4049240 Css NA 0.02028 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049240 Css NA 0.1329 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049240 Css NA 0.01636 mg/L PBTK NA 50% Rat Human -DTXSID4049240 Css NA 0.09423 mg/L PBTK NA 95% Rat Human -DTXSID4049242 Clint NA 1.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049242 Fup NA 0.2961 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049242 Vd NA 0.4215 L/kg 1compartment NA NA Human Human +DTXSID4049240 TK.Half.Life NA 0.8831 hours 1compartment NA NA Rat Human +DTXSID4049240 Css NA 0.008014 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049240 Css NA 0.04558 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049240 Css NA 0.006471 mg/L PBTK NA 50% Rat Human +DTXSID4049240 Css NA 0.0332 mg/L PBTK NA 95% Rat Human +DTXSID4049242 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049242 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049242 Vd NA 0.6049 L/kg 1compartment NA NA Human Human DTXSID4049242 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049242 TK.Half.Life NA 2.497 hours 1compartment NA NA Human Human -DTXSID4049242 Css NA 0.6634 mg/L 3compartmentss NA 50% Human Human -DTXSID4049242 Css NA 3.292 mg/L 3compartmentss NA 95% Human Human -DTXSID4049242 Css NA 0.4592 mg/L PBTK NA 50% Human Human -DTXSID4049242 Css NA 2.07 mg/L PBTK NA 95% Human Human -DTXSID4049242 Clint NA 1.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049242 Fup NA 0.2961 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049242 Vd NA 0.4155 L/kg 1compartment NA NA Rat Human +DTXSID4049242 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human +DTXSID4049242 Css NA 1.161 mg/L 3compartmentss NA 50% Human Human +DTXSID4049242 Css NA 7.772 mg/L 3compartmentss NA 95% Human Human +DTXSID4049242 Css NA 0.916 mg/L PBTK NA 50% Human Human +DTXSID4049242 Css NA 4.902 mg/L PBTK NA 95% Human Human +DTXSID4049242 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049242 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049242 Vd NA 0.6027 L/kg 1compartment NA NA Rat Human DTXSID4049242 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049242 TK.Half.Life NA 1.312 hours 1compartment NA NA Rat Human -DTXSID4049242 Css NA 0.298 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049242 Css NA 1.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049242 Css NA 0.197 mg/L PBTK NA 50% Rat Human -DTXSID4049242 Css NA 0.6391 mg/L PBTK NA 95% Rat Human -DTXSID4049244 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049244 Fup NA 0.3572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049244 Vd NA 1.867 L/kg 1compartment NA NA Human Human -DTXSID4049244 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID4049244 TK.Half.Life NA 51.38 hours 1compartment NA NA Human Human -DTXSID4049244 Css NA 2.912 mg/L 3compartmentss NA 50% Human Human -DTXSID4049244 Css NA 10.59 mg/L 3compartmentss NA 95% Human Human -DTXSID4049244 Css NA 2.303 mg/L PBTK NA 50% Human Human -DTXSID4049244 Css NA 7.159 mg/L PBTK NA 95% Human Human -DTXSID4049244 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049244 Fup NA 0.3572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049244 Vd NA 1.489 L/kg 1compartment NA NA Rat Human -DTXSID4049244 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4049244 TK.Half.Life NA 10.33 hours 1compartment NA NA Rat Human -DTXSID4049244 Css NA 0.7823 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049244 Css NA 2.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049244 Css NA 0.5938 mg/L PBTK NA 50% Rat Human -DTXSID4049244 Css NA 1.526 mg/L PBTK NA 95% Rat Human -DTXSID4049248 Clint NA 168.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049248 Fup NA 0.342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049248 Vd NA 3.142 L/kg 1compartment NA NA Human Human -DTXSID4049248 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049248 TK.Half.Life NA 12.61 hours 1compartment NA NA Human Human -DTXSID4049248 Css NA 0.394 mg/L 3compartmentss NA 50% Human Human -DTXSID4049248 Css NA 2.582 mg/L 3compartmentss NA 95% Human Human -DTXSID4049248 Css NA 0.2758 mg/L PBTK NA 50% Human Human -DTXSID4049248 Css NA 1.728 mg/L PBTK NA 95% Human Human -DTXSID4049248 Clint NA 168.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049248 Fup NA 0.342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049248 Vd NA 2.357 L/kg 1compartment NA NA Rat Human -DTXSID4049248 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049248 TK.Half.Life NA 2.109 hours 1compartment NA NA Rat Human -DTXSID4049248 Css NA 0.2207 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049248 Css NA 1.176 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049248 Css NA 0.1469 mg/L PBTK NA 50% Rat Human -DTXSID4049248 Css NA 0.7692 mg/L PBTK NA 95% Rat Human -DTXSID4049290 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049290 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049290 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID4049290 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4049290 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID4049290 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID4049290 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID4049290 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID4049290 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID4049290 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049290 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049290 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID4049290 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049290 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID4049290 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049290 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049290 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID4049290 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID4049298 Clint NA 196.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049298 Fup NA 0.1852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049298 Vd NA 2.746 L/kg 1compartment NA NA Human Human -DTXSID4049298 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049298 TK.Half.Life NA 3.052 hours 1compartment NA NA Human Human -DTXSID4049298 Css NA 0.04088 mg/L 3compartmentss NA 50% Human Human -DTXSID4049298 Css NA 0.2654 mg/L 3compartmentss NA 95% Human Human -DTXSID4049298 Css NA 0.02922 mg/L PBTK NA 50% Human Human -DTXSID4049298 Css NA 0.1812 mg/L PBTK NA 95% Human Human -DTXSID4049298 Clint NA 196.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049298 Fup NA 0.1852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049298 Vd NA 2.079 L/kg 1compartment NA NA Rat Human -DTXSID4049298 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049298 TK.Half.Life NA 0.8973 hours 1compartment NA NA Rat Human -DTXSID4049298 Css NA 0.0226 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049298 Css NA 0.1181 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049298 Css NA 0.01558 mg/L PBTK NA 50% Rat Human -DTXSID4049298 Css NA 0.07725 mg/L PBTK NA 95% Rat Human -DTXSID4049327 Clint NA 5.537 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049327 Fup NA 0.0339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049327 Vd NA 1.131 L/kg 1compartment NA NA Human Human -DTXSID4049327 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4049327 TK.Half.Life NA 22 hours 1compartment NA NA Human Human -DTXSID4049327 Css NA 3.401 mg/L 3compartmentss NA 50% Human Human -DTXSID4049327 Css NA 21.83 mg/L 3compartmentss NA 95% Human Human -DTXSID4049327 Css NA 2.114 mg/L PBTK NA 50% Human Human -DTXSID4049327 Css NA 12.9 mg/L PBTK NA 95% Human Human -DTXSID4049327 Clint NA 5.537 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049327 Fup NA 0.0339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049327 Vd NA 0.8454 L/kg 1compartment NA NA Rat Human -DTXSID4049327 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4049327 TK.Half.Life NA 9.022 hours 1compartment NA NA Rat Human -DTXSID4049327 Css NA 1.814 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049327 Css NA 8.427 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049327 Css NA 1.051 mg/L PBTK NA 50% Rat Human -DTXSID4049327 Css NA 4.696 mg/L PBTK NA 95% Rat Human -DTXSID4049329 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049329 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049329 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID4049329 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4049329 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID4049329 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID4049329 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID4049329 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID4049329 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID4049329 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049329 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049329 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID4049329 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049329 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID4049329 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049329 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049329 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID4049329 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID4049373 Clint NA 134.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049373 Fup NA 0.1483 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049373 Vd NA 1.296 L/kg 1compartment NA NA Human Human +DTXSID4049242 TK.Half.Life NA 2.104 hours 1compartment NA NA Rat Human +DTXSID4049242 Css NA 0.07058 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049242 Css NA 0.4236 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049242 Css NA 0.0557 mg/L PBTK NA 50% Rat Human +DTXSID4049242 Css NA 0.258 mg/L PBTK NA 95% Rat Human +DTXSID4049327 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049327 Fup 0.038 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049327 Vd NA 0.8525 L/kg 1compartment NA NA Human Human +DTXSID4049327 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4049327 TK.Half.Life NA 4.536 hours 1compartment NA NA Human Human +DTXSID4049327 Css NA 0.8022 mg/L 3compartmentss NA 50% Human Human +DTXSID4049327 Css NA 7.436 mg/L 3compartmentss NA 95% Human Human +DTXSID4049327 Css NA 0.4898 mg/L PBTK NA 50% Human Human +DTXSID4049327 Css NA 4.416 mg/L PBTK NA 95% Human Human +DTXSID4049327 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049327 Fup 0.038 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049327 Vd NA 0.6457 L/kg 1compartment NA NA Rat Human +DTXSID4049327 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4049327 TK.Half.Life NA 2.038 hours 1compartment NA NA Rat Human +DTXSID4049327 Css NA 0.1043 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049327 Css NA 0.7402 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049327 Css NA 0.06179 mg/L PBTK NA 50% Rat Human +DTXSID4049327 Css NA 0.4253 mg/L PBTK NA 95% Rat Human +DTXSID4049371 Clint 8.969 NA uL/min/million hepatocytes NA Pradeep 2020 NA Human Human +DTXSID4049371 Fup 0.6642 NA NA Pradeep 2020 NA Human Human +DTXSID4049371 Vd NA 0.5834 L/kg 1compartment NA NA Human Human +DTXSID4049371 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4049371 TK.Half.Life NA 0.6946 hours 1compartment NA NA Human Human +DTXSID4049371 Css NA 0.0624 mg/L 3compartmentss NA 50% Human Human +DTXSID4049371 Css NA 0.6646 mg/L 3compartmentss NA 95% Human Human +DTXSID4049371 Css NA 0.04782 mg/L PBTK NA 50% Human Human +DTXSID4049371 Css NA 0.4375 mg/L PBTK NA 95% Human Human +DTXSID4049371 Clint 8.969 NA uL/min/million hepatocytes NA Pradeep 2020 NA Rat Human +DTXSID4049371 Fup 0.6642 NA NA Pradeep 2020 NA Rat Human +DTXSID4049371 Vd NA 0.6163 L/kg 1compartment NA NA Rat Human +DTXSID4049371 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4049371 TK.Half.Life NA 0.3838 hours 1compartment NA NA Rat Human +DTXSID4049371 Css NA 0.002172 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049371 Css NA 0.02521 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049371 Css NA 0.001636 mg/L PBTK NA 50% Rat Human +DTXSID4049371 Css NA 0.01611 mg/L PBTK NA 95% Rat Human +DTXSID4049373 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049373 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049373 Vd NA 1.305 L/kg 1compartment NA NA Human Human DTXSID4049373 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049373 TK.Half.Life NA 1.326 hours 1compartment NA NA Human Human -DTXSID4049373 Css NA 0.03134 mg/L 3compartmentss NA 50% Human Human -DTXSID4049373 Css NA 0.2635 mg/L 3compartmentss NA 95% Human Human -DTXSID4049373 Css NA 0.02126 mg/L PBTK NA 50% Human Human -DTXSID4049373 Css NA 0.1689 mg/L PBTK NA 95% Human Human -DTXSID4049373 Clint NA 134.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049373 Fup NA 0.1483 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049373 Vd NA 1.02 L/kg 1compartment NA NA Rat Human +DTXSID4049373 TK.Half.Life NA 3.344 hours 1compartment NA NA Human Human +DTXSID4049373 Css NA 0.2156 mg/L 3compartmentss NA 50% Human Human +DTXSID4049373 Css NA 1.348 mg/L 3compartmentss NA 95% Human Human +DTXSID4049373 Css NA 0.1658 mg/L PBTK NA 50% Human Human +DTXSID4049373 Css NA 0.9098 mg/L PBTK NA 95% Human Human +DTXSID4049373 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049373 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049373 Vd NA 1.083 L/kg 1compartment NA NA Rat Human DTXSID4049373 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049373 TK.Half.Life NA 0.4868 hours 1compartment NA NA Rat Human -DTXSID4049373 Css NA 0.01797 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049373 Css NA 0.115 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049373 Css NA 0.0116 mg/L PBTK NA 50% Rat Human -DTXSID4049373 Css NA 0.07088 mg/L PBTK NA 95% Rat Human -DTXSID4049377 Clint NA 0.08436 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049377 Fup NA 0.7594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049377 Vd NA 0.512 L/kg 1compartment NA NA Human Human +DTXSID4049373 TK.Half.Life NA 1.447 hours 1compartment NA NA Rat Human +DTXSID4049373 Css NA 0.02552 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049373 Css NA 0.1198 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049373 Css NA 0.01946 mg/L PBTK NA 50% Rat Human +DTXSID4049373 Css NA 0.07949 mg/L PBTK NA 95% Rat Human +DTXSID4049377 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049377 Fup 0.709 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049377 Vd NA 0.404 L/kg 1compartment NA NA Human Human DTXSID4049377 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049377 TK.Half.Life NA 3.83 hours 1compartment NA NA Human Human -DTXSID4049377 Css NA 0.9611 mg/L 3compartmentss NA 50% Human Human -DTXSID4049377 Css NA 5.694 mg/L 3compartmentss NA 95% Human Human -DTXSID4049377 Css NA 0.7208 mg/L PBTK NA 50% Human Human -DTXSID4049377 Css NA 3.578 mg/L PBTK NA 95% Human Human -DTXSID4049377 Clint NA 0.08436 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049377 Fup NA 0.7594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049377 Vd NA 0.535 L/kg 1compartment NA NA Rat Human +DTXSID4049377 TK.Half.Life NA 3.687 hours 1compartment NA NA Human Human +DTXSID4049377 Css NA 1.185 mg/L 3compartmentss NA 50% Human Human +DTXSID4049377 Css NA 7.385 mg/L 3compartmentss NA 95% Human Human +DTXSID4049377 Css NA 0.8494 mg/L PBTK NA 50% Human Human +DTXSID4049377 Css NA 4.508 mg/L PBTK NA 95% Human Human +DTXSID4049377 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049377 Fup 0.709 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049377 Vd NA 0.4254 L/kg 1compartment NA NA Rat Human DTXSID4049377 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049377 TK.Half.Life NA 1.455 hours 1compartment NA NA Rat Human -DTXSID4049377 Css NA 0.2716 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049377 Css NA 1.619 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049377 Css NA 0.195 mg/L PBTK NA 50% Rat Human -DTXSID4049377 Css NA 0.9358 mg/L PBTK NA 95% Rat Human -DTXSID4049379 Clint NA 2.478 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049379 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049379 Vd NA 0.2787 L/kg 1compartment NA NA Human Human +DTXSID4049377 TK.Half.Life NA 1.323 hours 1compartment NA NA Rat Human +DTXSID4049377 Css NA 0.07145 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049377 Css NA 0.4238 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049377 Css NA 0.0507 mg/L PBTK NA 50% Rat Human +DTXSID4049377 Css NA 0.2499 mg/L PBTK NA 95% Rat Human +DTXSID4049379 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049379 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049379 Vd NA 0.3246 L/kg 1compartment NA NA Human Human DTXSID4049379 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049379 TK.Half.Life NA 3.558 hours 1compartment NA NA Human Human -DTXSID4049379 Css NA 2.021 mg/L 3compartmentss NA 50% Human Human -DTXSID4049379 Css NA 11.74 mg/L 3compartmentss NA 95% Human Human -DTXSID4049379 Css NA 1.247 mg/L PBTK NA 50% Human Human -DTXSID4049379 Css NA 6.947 mg/L PBTK NA 95% Human Human -DTXSID4049379 Clint NA 2.478 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049379 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049379 Vd NA 0.2738 L/kg 1compartment NA NA Rat Human +DTXSID4049379 TK.Half.Life NA 1.429 hours 1compartment NA NA Human Human +DTXSID4049379 Css NA 0.5362 mg/L 3compartmentss NA 50% Human Human +DTXSID4049379 Css NA 3.704 mg/L 3compartmentss NA 95% Human Human +DTXSID4049379 Css NA 0.3427 mg/L PBTK NA 50% Human Human +DTXSID4049379 Css NA 2.21 mg/L PBTK NA 95% Human Human +DTXSID4049379 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049379 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049379 Vd NA 0.3197 L/kg 1compartment NA NA Rat Human DTXSID4049379 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049379 TK.Half.Life NA 1.985 hours 1compartment NA NA Rat Human -DTXSID4049379 Css NA 0.9596 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049379 Css NA 4.221 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049379 Css NA 0.5557 mg/L PBTK NA 50% Rat Human -DTXSID4049379 Css NA 2.336 mg/L PBTK NA 95% Rat Human -DTXSID4049400 Clint NA 5.911 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049400 Fup NA 0.0591 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049400 Vd NA 2.165 L/kg 1compartment NA NA Human Human -DTXSID4049400 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4049400 TK.Half.Life NA 34.73 hours 1compartment NA NA Human Human -DTXSID4049400 Css NA 2.302 mg/L 3compartmentss NA 50% Human Human -DTXSID4049400 Css NA 13.48 mg/L 3compartmentss NA 95% Human Human -DTXSID4049400 Css NA 1.535 mg/L PBTK NA 50% Human Human -DTXSID4049400 Css NA 8.517 mg/L PBTK NA 95% Human Human -DTXSID4049400 Clint NA 5.911 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049400 Fup NA 0.0591 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049400 Vd NA 1.625 L/kg 1compartment NA NA Rat Human -DTXSID4049400 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID4049400 TK.Half.Life NA 10.05 hours 1compartment NA NA Rat Human -DTXSID4049400 Css NA 1.232 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049400 Css NA 5.438 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049400 Css NA 0.7759 mg/L PBTK NA 50% Rat Human -DTXSID4049400 Css NA 3.245 mg/L PBTK NA 95% Rat Human -DTXSID4049402 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049402 Fup NA 0.7427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049402 Vd NA 0.6427 L/kg 1compartment NA NA Human Human -DTXSID4049402 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049402 TK.Half.Life NA 5.599 hours 1compartment NA NA Human Human -DTXSID4049402 Css NA 1.066 mg/L 3compartmentss NA 50% Human Human -DTXSID4049402 Css NA 6.54 mg/L 3compartmentss NA 95% Human Human -DTXSID4049402 Css NA 0.8514 mg/L PBTK NA 50% Human Human -DTXSID4049402 Css NA 4.154 mg/L PBTK NA 95% Human Human -DTXSID4049402 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049402 Fup NA 0.7427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049402 Vd NA 0.675 L/kg 1compartment NA NA Rat Human -DTXSID4049402 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049402 TK.Half.Life NA 2.004 hours 1compartment NA NA Rat Human -DTXSID4049402 Css NA 0.2738 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049402 Css NA 1.742 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049402 Css NA 0.2113 mg/L PBTK NA 50% Rat Human -DTXSID4049402 Css NA 1.024 mg/L PBTK NA 95% Rat Human +DTXSID4049379 TK.Half.Life NA 0.8401 hours 1compartment NA NA Rat Human +DTXSID4049379 Css NA 0.06528 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049379 Css NA 0.3265 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049379 Css NA 0.04073 mg/L PBTK NA 50% Rat Human +DTXSID4049379 Css NA 0.191 mg/L PBTK NA 95% Rat Human +DTXSID4049400 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049400 Fup 0.02 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049400 Vd NA 1.546 L/kg 1compartment NA NA Human Human +DTXSID4049400 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4049400 TK.Half.Life NA 14.34 hours 1compartment NA NA Human Human +DTXSID4049400 Css NA 1.423 mg/L 3compartmentss NA 50% Human Human +DTXSID4049400 Css NA 12.62 mg/L 3compartmentss NA 95% Human Human +DTXSID4049400 Css NA 0.8932 mg/L PBTK NA 50% Human Human +DTXSID4049400 Css NA 7.633 mg/L PBTK NA 95% Human Human +DTXSID4049400 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049400 Fup 0.02 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049400 Vd NA 1.147 L/kg 1compartment NA NA Rat Human +DTXSID4049400 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4049400 TK.Half.Life NA 5.441 hours 1compartment NA NA Rat Human +DTXSID4049400 Css NA 0.1838 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049400 Css NA 1.351 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049400 Css NA 0.112 mg/L PBTK NA 50% Rat Human +DTXSID4049400 Css NA 0.7918 mg/L PBTK NA 95% Rat Human DTXSID4049404 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4049404 Fup NA 0.7428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049404 Vd NA 0.6914 L/kg 1compartment NA NA Human Human +DTXSID4049404 Vd NA 0.6687 L/kg 1compartment NA NA Human Human DTXSID4049404 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049404 TK.Half.Life NA 6.027 hours 1compartment NA NA Human Human -DTXSID4049404 Css NA 1.047 mg/L 3compartmentss NA 50% Human Human -DTXSID4049404 Css NA 6.436 mg/L 3compartmentss NA 95% Human Human -DTXSID4049404 Css NA 0.8512 mg/L PBTK NA 50% Human Human -DTXSID4049404 Css NA 4.144 mg/L PBTK NA 95% Human Human +DTXSID4049404 TK.Half.Life NA 5.83 hours 1compartment NA NA Human Human +DTXSID4049404 Css NA 0.9036 mg/L 3compartmentss NA 50% Human Human +DTXSID4049404 Css NA 5.631 mg/L 3compartmentss NA 95% Human Human +DTXSID4049404 Css NA 0.7276 mg/L PBTK NA 50% Human Human +DTXSID4049404 Css NA 3.6 mg/L PBTK NA 95% Human Human DTXSID4049404 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4049404 Fup NA 0.7428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049404 Vd NA 0.7184 L/kg 1compartment NA NA Rat Human +DTXSID4049404 Vd NA 0.6985 L/kg 1compartment NA NA Rat Human DTXSID4049404 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049404 TK.Half.Life NA 2.133 hours 1compartment NA NA Rat Human -DTXSID4049404 Css NA 0.2728 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049404 Css NA 1.739 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049404 Css NA 0.213 mg/L PBTK NA 50% Rat Human -DTXSID4049404 Css NA 1.026 mg/L PBTK NA 95% Rat Human -DTXSID4049406 Clint NA 123.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049406 Fup NA 0.1154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049406 Vd NA 1.602 L/kg 1compartment NA NA Human Human +DTXSID4049404 TK.Half.Life NA 2.073 hours 1compartment NA NA Rat Human +DTXSID4049404 Css NA 0.01714 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049404 Css NA 0.1391 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049404 Css NA 0.01316 mg/L PBTK NA 50% Rat Human +DTXSID4049404 Css NA 0.08804 mg/L PBTK NA 95% Rat Human +DTXSID4049406 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049406 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4049406 Vd NA 1.672 L/kg 1compartment NA NA Human Human DTXSID4049406 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4049406 TK.Half.Life NA 1.84 hours 1compartment NA NA Human Human -DTXSID4049406 Css NA 0.05079 mg/L 3compartmentss NA 50% Human Human -DTXSID4049406 Css NA 0.384 mg/L 3compartmentss NA 95% Human Human -DTXSID4049406 Css NA 0.03425 mg/L PBTK NA 50% Human Human -DTXSID4049406 Css NA 0.242 mg/L PBTK NA 95% Human Human -DTXSID4049406 Clint NA 123.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049406 Fup NA 0.1154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049406 Vd NA 1.228 L/kg 1compartment NA NA Rat Human +DTXSID4049406 TK.Half.Life NA 4.133 hours 1compartment NA NA Human Human +DTXSID4049406 Css NA 0.2406 mg/L 3compartmentss NA 50% Human Human +DTXSID4049406 Css NA 1.807 mg/L 3compartmentss NA 95% Human Human +DTXSID4049406 Css NA 0.1639 mg/L PBTK NA 50% Human Human +DTXSID4049406 Css NA 1.172 mg/L PBTK NA 95% Human Human +DTXSID4049406 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049406 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4049406 Vd NA 1.284 L/kg 1compartment NA NA Rat Human DTXSID4049406 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4049406 TK.Half.Life NA 0.6515 hours 1compartment NA NA Rat Human -DTXSID4049406 Css NA 0.02871 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049406 Css NA 0.1758 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049406 Css NA 0.01825 mg/L PBTK NA 50% Rat Human -DTXSID4049406 Css NA 0.1069 mg/L PBTK NA 95% Rat Human -DTXSID4049408 Clint NA 31.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049408 Fup NA 0.0097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4049408 Vd NA 2.908 L/kg 1compartment NA NA Human Human -DTXSID4049408 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID4049408 TK.Half.Life NA 45.39 hours 1compartment NA NA Human Human -DTXSID4049408 Css NA 2.03 mg/L 3compartmentss NA 50% Human Human -DTXSID4049408 Css NA 13.52 mg/L 3compartmentss NA 95% Human Human -DTXSID4049408 Css NA 1.379 mg/L PBTK NA 50% Human Human -DTXSID4049408 Css NA 8.761 mg/L PBTK NA 95% Human Human -DTXSID4049408 Clint NA 31.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049408 Fup NA 0.0097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4049408 Vd NA 2.174 L/kg 1compartment NA NA Rat Human -DTXSID4049408 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4049408 TK.Half.Life NA 8.058 hours 1compartment NA NA Rat Human -DTXSID4049408 Css NA 1.15 mg/L 3compartmentss NA 50% Rat Human -DTXSID4049408 Css NA 6.275 mg/L 3compartmentss NA 95% Rat Human -DTXSID4049408 Css NA 0.7426 mg/L PBTK NA 50% Rat Human -DTXSID4049408 Css NA 3.954 mg/L PBTK NA 95% Rat Human -DTXSID4051536 Clint NA 0.01125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4051536 Fup NA 0.8395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4051536 Vd NA 1.06 L/kg 1compartment NA NA Human Human +DTXSID4049406 TK.Half.Life NA 1.535 hours 1compartment NA NA Rat Human +DTXSID4049406 Css NA 0.03076 mg/L 3compartmentss NA 50% Rat Human +DTXSID4049406 Css NA 0.1816 mg/L 3compartmentss NA 95% Rat Human +DTXSID4049406 Css NA 0.0206 mg/L PBTK NA 50% Rat Human +DTXSID4049406 Css NA 0.113 mg/L PBTK NA 95% Rat Human +DTXSID4051536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051536 Fup 0.574 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051536 Vd NA 0.8876 L/kg 1compartment NA NA Human Human DTXSID4051536 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4051536 TK.Half.Life NA 8.248 hours 1compartment NA NA Human Human -DTXSID4051536 Css NA 0.8975 mg/L 3compartmentss NA 50% Human Human -DTXSID4051536 Css NA 5.486 mg/L 3compartmentss NA 95% Human Human -DTXSID4051536 Css NA 0.79 mg/L PBTK NA 50% Human Human -DTXSID4051536 Css NA 3.651 mg/L PBTK NA 95% Human Human -DTXSID4051536 Clint NA 0.01125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4051536 Fup NA 0.8395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4051536 Vd NA 1.026 L/kg 1compartment NA NA Rat Human +DTXSID4051536 TK.Half.Life NA 0.8115 hours 1compartment NA NA Human Human +DTXSID4051536 Css NA 0.02732 mg/L 3compartmentss NA 50% Human Human +DTXSID4051536 Css NA 0.3195 mg/L 3compartmentss NA 95% Human Human +DTXSID4051536 Css NA 0.02212 mg/L PBTK NA 50% Human Human +DTXSID4051536 Css NA 0.2178 mg/L PBTK NA 95% Human Human +DTXSID4051536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051536 Fup 0.574 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051536 Vd NA 0.8467 L/kg 1compartment NA NA Rat Human DTXSID4051536 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4051536 TK.Half.Life NA 2.689 hours 1compartment NA NA Rat Human -DTXSID4051536 Css NA 0.2296 mg/L 3compartmentss NA 50% Rat Human -DTXSID4051536 Css NA 1.408 mg/L 3compartmentss NA 95% Rat Human -DTXSID4051536 Css NA 0.1977 mg/L PBTK NA 50% Rat Human -DTXSID4051536 Css NA 0.8641 mg/L PBTK NA 95% Rat Human -DTXSID4051580 Clint NA 7.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4051580 Fup NA 0.9439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4051580 Vd NA 0.9592 L/kg 1compartment NA NA Human Human +DTXSID4051536 TK.Half.Life NA 0.3849 hours 1compartment NA NA Rat Human +DTXSID4051536 Css NA 0.0009662 mg/L 3compartmentss NA 50% Rat Human +DTXSID4051536 Css NA 0.01324 mg/L 3compartmentss NA 95% Rat Human +DTXSID4051536 Css NA 0.0007803 mg/L PBTK NA 50% Rat Human +DTXSID4051536 Css NA 0.008942 mg/L PBTK NA 95% Rat Human +DTXSID4051580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051580 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051580 Vd NA 0.6615 L/kg 1compartment NA NA Human Human DTXSID4051580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4051580 TK.Half.Life NA 0.9238 hours 1compartment NA NA Human Human -DTXSID4051580 Css NA 0.0659 mg/L 3compartmentss NA 50% Human Human -DTXSID4051580 Css NA 0.5835 mg/L 3compartmentss NA 95% Human Human -DTXSID4051580 Css NA 0.05594 mg/L PBTK NA 50% Human Human -DTXSID4051580 Css NA 0.4134 mg/L PBTK NA 95% Human Human -DTXSID4051580 Clint NA 7.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4051580 Fup NA 0.9439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4051580 Vd NA 0.9668 L/kg 1compartment NA NA Rat Human +DTXSID4051580 TK.Half.Life NA 8.601 hours 1compartment NA NA Human Human +DTXSID4051580 Css NA 1.218 mg/L 3compartmentss NA 50% Human Human +DTXSID4051580 Css NA 6.386 mg/L 3compartmentss NA 95% Human Human +DTXSID4051580 Css NA 0.9462 mg/L PBTK NA 50% Human Human +DTXSID4051580 Css NA 4.08 mg/L PBTK NA 95% Human Human +DTXSID4051580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051580 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051580 Vd NA 0.6625 L/kg 1compartment NA NA Rat Human DTXSID4051580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4051580 TK.Half.Life NA 0.4787 hours 1compartment NA NA Rat Human -DTXSID4051580 Css NA 0.03127 mg/L 3compartmentss NA 50% Rat Human -DTXSID4051580 Css NA 0.2329 mg/L 3compartmentss NA 95% Rat Human -DTXSID4051580 Css NA 0.02641 mg/L PBTK NA 50% Rat Human -DTXSID4051580 Css NA 0.1504 mg/L PBTK NA 95% Rat Human +DTXSID4051580 TK.Half.Life NA 2.925 hours 1compartment NA NA Rat Human +DTXSID4051580 Css NA 0.02252 mg/L 3compartmentss NA 50% Rat Human +DTXSID4051580 Css NA 0.1605 mg/L 3compartmentss NA 95% Rat Human +DTXSID4051580 Css NA 0.01682 mg/L PBTK NA 50% Rat Human +DTXSID4051580 Css NA 0.1035 mg/L PBTK NA 95% Rat Human +DTXSID4051584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051584 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051584 Vd NA 2.114 L/kg 1compartment NA NA Human Human +DTXSID4051584 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4051584 TK.Half.Life NA 5.279 hours 1compartment NA NA Human Human +DTXSID4051584 Css NA 0.2208 mg/L 3compartmentss NA 50% Human Human +DTXSID4051584 Css NA 1.541 mg/L 3compartmentss NA 95% Human Human +DTXSID4051584 Css NA 0.1564 mg/L PBTK NA 50% Human Human +DTXSID4051584 Css NA 1.005 mg/L PBTK NA 95% Human Human +DTXSID4051584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051584 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051584 Vd NA 1.615 L/kg 1compartment NA NA Rat Human +DTXSID4051584 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4051584 TK.Half.Life NA 1.713 hours 1compartment NA NA Rat Human +DTXSID4051584 Css NA 0.02826 mg/L 3compartmentss NA 50% Rat Human +DTXSID4051584 Css NA 0.1507 mg/L 3compartmentss NA 95% Rat Human +DTXSID4051584 Css NA 0.01983 mg/L PBTK NA 50% Rat Human +DTXSID4051584 Css NA 0.09919 mg/L PBTK NA 95% Rat Human DTXSID4051619 Clint NA 3.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4051619 Fup NA 0.1569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4051619 Vd NA 2.208 L/kg 1compartment NA NA Human Human -DTXSID4051619 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4051619 TK.Half.Life NA 23.82 hours 1compartment NA NA Human Human -DTXSID4051619 Css NA 1.346 mg/L 3compartmentss NA 50% Human Human -DTXSID4051619 Css NA 6.851 mg/L 3compartmentss NA 95% Human Human -DTXSID4051619 Css NA 0.9486 mg/L PBTK NA 50% Human Human -DTXSID4051619 Css NA 4.506 mg/L PBTK NA 95% Human Human +DTXSID4051619 Vd NA 1.737 L/kg 1compartment NA NA Human Human +DTXSID4051619 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4051619 TK.Half.Life NA 14.52 hours 1compartment NA NA Human Human +DTXSID4051619 Css NA 1.022 mg/L 3compartmentss NA 50% Human Human +DTXSID4051619 Css NA 5.729 mg/L 3compartmentss NA 95% Human Human +DTXSID4051619 Css NA 0.7151 mg/L PBTK NA 50% Human Human +DTXSID4051619 Css NA 3.704 mg/L PBTK NA 95% Human Human DTXSID4051619 Clint NA 3.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4051619 Fup NA 0.1569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4051619 Vd NA 1.683 L/kg 1compartment NA NA Rat Human -DTXSID4051619 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4051619 TK.Half.Life NA 6.723 hours 1compartment NA NA Rat Human -DTXSID4051619 Css NA 0.6732 mg/L 3compartmentss NA 50% Rat Human -DTXSID4051619 Css NA 2.475 mg/L 3compartmentss NA 95% Rat Human -DTXSID4051619 Css NA 0.4526 mg/L PBTK NA 50% Rat Human -DTXSID4051619 Css NA 1.508 mg/L PBTK NA 95% Rat Human +DTXSID4051619 Vd NA 1.341 L/kg 1compartment NA NA Rat Human +DTXSID4051619 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4051619 TK.Half.Life NA 5.045 hours 1compartment NA NA Rat Human +DTXSID4051619 Css NA 0.1177 mg/L 3compartmentss NA 50% Rat Human +DTXSID4051619 Css NA 0.4642 mg/L 3compartmentss NA 95% Rat Human +DTXSID4051619 Css NA 0.08096 mg/L PBTK NA 50% Rat Human +DTXSID4051619 Css NA 0.2907 mg/L PBTK NA 95% Rat Human +DTXSID4051873 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051873 Fup 0.0345 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051873 Vd NA 2.765 L/kg 1compartment NA NA Human Human +DTXSID4051873 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4051873 TK.Half.Life NA 31.44 hours 1compartment NA NA Human Human +DTXSID4051873 Css NA 1.428 mg/L 3compartmentss NA 50% Human Human +DTXSID4051873 Css NA 9.154 mg/L 3compartmentss NA 95% Human Human +DTXSID4051873 Css NA 0.966 mg/L PBTK NA 50% Human Human +DTXSID4051873 Css NA 5.962 mg/L PBTK NA 95% Human Human +DTXSID4051873 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051873 Fup 0.0345 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051873 Vd NA 2.069 L/kg 1compartment NA NA Rat Human +DTXSID4051873 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID4051873 TK.Half.Life NA 6.454 hours 1compartment NA NA Rat Human +DTXSID4051873 Css NA 0.1856 mg/L 3compartmentss NA 50% Rat Human +DTXSID4051873 Css NA 1.041 mg/L 3compartmentss NA 95% Rat Human +DTXSID4051873 Css NA 0.1239 mg/L PBTK NA 50% Rat Human +DTXSID4051873 Css NA 0.6772 mg/L PBTK NA 95% Rat Human +DTXSID4051900 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051900 Fup 0.726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051900 Vd NA 3.121 L/kg 1compartment NA NA Human Human +DTXSID4051900 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4051900 TK.Half.Life NA 27.94 hours 1compartment NA NA Human Human +DTXSID4051900 Css NA 0.704 mg/L 3compartmentss NA 50% Human Human +DTXSID4051900 Css NA 5.856 mg/L 3compartmentss NA 95% Human Human +DTXSID4051900 Css NA 0.8397 mg/L PBTK NA 50% Human Human +DTXSID4051900 Css NA 4.272 mg/L PBTK NA 95% Human Human +DTXSID4051900 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051900 Fup 0.726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051900 Vd NA 3.178 L/kg 1compartment NA NA Rat Human +DTXSID4051900 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4051900 TK.Half.Life NA 9.662 hours 1compartment NA NA Rat Human +DTXSID4051900 Css NA 0.04097 mg/L 3compartmentss NA 50% Rat Human +DTXSID4051900 Css NA 0.3226 mg/L 3compartmentss NA 95% Rat Human +DTXSID4051900 Css NA 0.05032 mg/L PBTK NA 50% Rat Human +DTXSID4051900 Css NA 0.2282 mg/L PBTK NA 95% Rat Human +DTXSID4051904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051904 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4051904 Vd NA 2.701 L/kg 1compartment NA NA Human Human +DTXSID4051904 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4051904 TK.Half.Life NA 8.806 hours 1compartment NA NA Human Human +DTXSID4051904 Css NA 0.2967 mg/L 3compartmentss NA 50% Human Human +DTXSID4051904 Css NA 1.855 mg/L 3compartmentss NA 95% Human Human +DTXSID4051904 Css NA 0.2127 mg/L PBTK NA 50% Human Human +DTXSID4051904 Css NA 1.29 mg/L PBTK NA 95% Human Human +DTXSID4051904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051904 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4051904 Vd NA 2.049 L/kg 1compartment NA NA Rat Human +DTXSID4051904 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4051904 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human +DTXSID4051904 Css NA 0.03717 mg/L 3compartmentss NA 50% Rat Human +DTXSID4051904 Css NA 0.1852 mg/L 3compartmentss NA 95% Rat Human +DTXSID4051904 Css NA 0.02677 mg/L PBTK NA 50% Rat Human +DTXSID4051904 Css NA 0.1272 mg/L PBTK NA 95% Rat Human +DTXSID4052134 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052134 Fup 0.366 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052134 Vd NA 0.7381 L/kg 1compartment NA NA Human Human +DTXSID4052134 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4052134 TK.Half.Life NA 1.608 hours 1compartment NA NA Human Human +DTXSID4052134 Css NA 0.1774 mg/L 3compartmentss NA 50% Human Human +DTXSID4052134 Css NA 1.142 mg/L 3compartmentss NA 95% Human Human +DTXSID4052134 Css NA 0.1322 mg/L PBTK NA 50% Human Human +DTXSID4052134 Css NA 0.7633 mg/L PBTK NA 95% Human Human +DTXSID4052134 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052134 Fup 0.366 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052134 Vd NA 0.6901 L/kg 1compartment NA NA Rat Human +DTXSID4052134 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4052134 TK.Half.Life NA 0.8377 hours 1compartment NA NA Rat Human +DTXSID4052134 Css NA 0.02081 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052134 Css NA 0.1035 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052134 Css NA 0.01545 mg/L PBTK NA 50% Rat Human +DTXSID4052134 Css NA 0.0667 mg/L PBTK NA 95% Rat Human DTXSID4052186 Clint NA 3.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4052186 Fup NA 0.3814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4052186 Vd NA 2.641 L/kg 1compartment NA NA Human Human DTXSID4052186 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID4052186 TK.Half.Life NA 20.56 hours 1compartment NA NA Human Human -DTXSID4052186 Css NA 0.8352 mg/L 3compartmentss NA 50% Human Human -DTXSID4052186 Css NA 3.734 mg/L 3compartmentss NA 95% Human Human -DTXSID4052186 Css NA 0.6365 mg/L PBTK NA 50% Human Human -DTXSID4052186 Css NA 2.671 mg/L PBTK NA 95% Human Human +DTXSID4052186 Css NA 0.6859 mg/L 3compartmentss NA 50% Human Human +DTXSID4052186 Css NA 3.38 mg/L 3compartmentss NA 95% Human Human +DTXSID4052186 Css NA 0.5265 mg/L PBTK NA 50% Human Human +DTXSID4052186 Css NA 2.434 mg/L PBTK NA 95% Human Human DTXSID4052186 Clint NA 3.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4052186 Fup NA 0.3814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4052186 Vd NA 2.035 L/kg 1compartment NA NA Rat Human DTXSID4052186 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID4052186 TK.Half.Life NA 4.665 hours 1compartment NA NA Rat Human -DTXSID4052186 Css NA 0.3986 mg/L 3compartmentss NA 50% Rat Human -DTXSID4052186 Css NA 1.303 mg/L 3compartmentss NA 95% Rat Human -DTXSID4052186 Css NA 0.2954 mg/L PBTK NA 50% Rat Human -DTXSID4052186 Css NA 0.8763 mg/L PBTK NA 95% Rat Human -DTXSID4052213 Clint NA 1.173 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052213 Fup NA 0.5903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052213 Vd NA 1.477 L/kg 1compartment NA NA Human Human +DTXSID4052186 Css NA 0.02182 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052186 Css NA 0.1296 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052186 Css NA 0.01638 mg/L PBTK NA 50% Rat Human +DTXSID4052186 Css NA 0.09102 mg/L PBTK NA 95% Rat Human +DTXSID4052213 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052213 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052213 Vd NA 0.9349 L/kg 1compartment NA NA Human Human DTXSID4052213 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4052213 TK.Half.Life NA 6.73 hours 1compartment NA NA Human Human -DTXSID4052213 Css NA 0.4444 mg/L 3compartmentss NA 50% Human Human -DTXSID4052213 Css NA 3.172 mg/L 3compartmentss NA 95% Human Human -DTXSID4052213 Css NA 0.388 mg/L PBTK NA 50% Human Human -DTXSID4052213 Css NA 2.082 mg/L PBTK NA 95% Human Human -DTXSID4052213 Clint NA 1.173 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052213 Fup NA 0.5903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052213 Vd NA 1.274 L/kg 1compartment NA NA Rat Human +DTXSID4052213 TK.Half.Life NA 1.336 hours 1compartment NA NA Human Human +DTXSID4052213 Css NA 0.08192 mg/L 3compartmentss NA 50% Human Human +DTXSID4052213 Css NA 0.5973 mg/L 3compartmentss NA 95% Human Human +DTXSID4052213 Css NA 0.05886 mg/L PBTK NA 50% Human Human +DTXSID4052213 Css NA 0.3983 mg/L PBTK NA 95% Human Human +DTXSID4052213 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052213 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052213 Vd NA 0.7994 L/kg 1compartment NA NA Rat Human DTXSID4052213 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4052213 TK.Half.Life NA 2.585 hours 1compartment NA NA Rat Human -DTXSID4052213 Css NA 0.1807 mg/L 3compartmentss NA 50% Rat Human -DTXSID4052213 Css NA 1.122 mg/L 3compartmentss NA 95% Rat Human -DTXSID4052213 Css NA 0.1526 mg/L PBTK NA 50% Rat Human -DTXSID4052213 Css NA 0.6887 mg/L PBTK NA 95% Rat Human -DTXSID4052267 Clint NA 62.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052267 Fup NA 0.1502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052267 Vd NA 2.069 L/kg 1compartment NA NA Human Human +DTXSID4052213 TK.Half.Life NA 0.6017 hours 1compartment NA NA Rat Human +DTXSID4052213 Css NA 0.01023 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052213 Css NA 0.05758 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052213 Css NA 0.007344 mg/L PBTK NA 50% Rat Human +DTXSID4052213 Css NA 0.03817 mg/L PBTK NA 95% Rat Human +DTXSID4052267 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052267 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052267 Vd NA 1.81 L/kg 1compartment NA NA Human Human DTXSID4052267 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4052267 TK.Half.Life NA 2.926 hours 1compartment NA NA Human Human -DTXSID4052267 Css NA 0.08822 mg/L 3compartmentss NA 50% Human Human -DTXSID4052267 Css NA 0.6282 mg/L 3compartmentss NA 95% Human Human -DTXSID4052267 Css NA 0.06113 mg/L PBTK NA 50% Human Human -DTXSID4052267 Css NA 0.4164 mg/L PBTK NA 95% Human Human -DTXSID4052267 Clint NA 62.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052267 Fup NA 0.1502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052267 Vd NA 1.581 L/kg 1compartment NA NA Rat Human +DTXSID4052267 TK.Half.Life NA 3.29 hours 1compartment NA NA Human Human +DTXSID4052267 Css NA 0.1275 mg/L 3compartmentss NA 50% Human Human +DTXSID4052267 Css NA 0.8294 mg/L 3compartmentss NA 95% Human Human +DTXSID4052267 Css NA 0.09343 mg/L PBTK NA 50% Human Human +DTXSID4052267 Css NA 0.5814 mg/L PBTK NA 95% Human Human +DTXSID4052267 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052267 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052267 Vd NA 1.411 L/kg 1compartment NA NA Rat Human DTXSID4052267 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4052267 TK.Half.Life NA 0.9715 hours 1compartment NA NA Rat Human -DTXSID4052267 Css NA 0.0488 mg/L 3compartmentss NA 50% Rat Human -DTXSID4052267 Css NA 0.2906 mg/L 3compartmentss NA 95% Rat Human -DTXSID4052267 Css NA 0.03252 mg/L PBTK NA 50% Rat Human -DTXSID4052267 Css NA 0.1849 mg/L PBTK NA 95% Rat Human -DTXSID4052269 Clint NA 18.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052269 Fup NA 0.4635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052269 Vd NA 714.4 L/kg 1compartment NA NA Human Human -DTXSID4052269 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID4052269 TK.Half.Life NA 24960 hours 1compartment NA NA Human Human -DTXSID4052269 Css NA 0.02586 mg/L 3compartmentss NA 50% Human Human -DTXSID4052269 Css NA 0.1584 mg/L 3compartmentss NA 95% Human Human -DTXSID4052269 Css NA 2.867 mg/L PBTK NA 50% Human Human -DTXSID4052269 Css NA 16.47 mg/L PBTK NA 95% Human Human -DTXSID4052269 Clint NA 18.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052269 Fup NA 0.4635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052269 Vd NA 650.2 L/kg 1compartment NA NA Rat Human -DTXSID4052269 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID4052269 TK.Half.Life NA 3802 hours 1compartment NA NA Rat Human -DTXSID4052269 Css NA 0.0132 mg/L 3compartmentss NA 50% Rat Human -DTXSID4052269 Css NA 0.05877 mg/L 3compartmentss NA 95% Rat Human -DTXSID4052269 Css NA 1.558 mg/L PBTK NA 50% Rat Human -DTXSID4052269 Css NA 7.04 mg/L PBTK NA 95% Rat Human -DTXSID4052342 Clint NA 0.4923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052342 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052342 Vd NA 0.8311 L/kg 1compartment NA NA Human Human +DTXSID4052267 TK.Half.Life NA 1.193 hours 1compartment NA NA Rat Human +DTXSID4052267 Css NA 0.01594 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052267 Css NA 0.08266 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052267 Css NA 0.01159 mg/L PBTK NA 50% Rat Human +DTXSID4052267 Css NA 0.05744 mg/L PBTK NA 95% Rat Human +DTXSID4052342 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052342 Fup 0.813 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052342 Vd NA 0.7327 L/kg 1compartment NA NA Human Human DTXSID4052342 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4052342 TK.Half.Life NA 3.064 hours 1compartment NA NA Human Human -DTXSID4052342 Css NA 0.4474 mg/L 3compartmentss NA 50% Human Human -DTXSID4052342 Css NA 3.101 mg/L 3compartmentss NA 95% Human Human -DTXSID4052342 Css NA 0.381 mg/L PBTK NA 50% Human Human -DTXSID4052342 Css NA 2.042 mg/L PBTK NA 95% Human Human -DTXSID4052342 Clint NA 0.4923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052342 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052342 Vd NA 0.8611 L/kg 1compartment NA NA Rat Human +DTXSID4052342 TK.Half.Life NA 5.839 hours 1compartment NA NA Human Human +DTXSID4052342 Css NA 0.9491 mg/L 3compartmentss NA 50% Human Human +DTXSID4052342 Css NA 5.608 mg/L 3compartmentss NA 95% Human Human +DTXSID4052342 Css NA 0.7845 mg/L PBTK NA 50% Human Human +DTXSID4052342 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID4052342 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052342 Fup 0.813 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052342 Vd NA 0.7583 L/kg 1compartment NA NA Rat Human DTXSID4052342 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4052342 TK.Half.Life NA 1.379 hours 1compartment NA NA Rat Human -DTXSID4052342 Css NA 0.1479 mg/L 3compartmentss NA 50% Rat Human -DTXSID4052342 Css NA 0.9337 mg/L 3compartmentss NA 95% Rat Human -DTXSID4052342 Css NA 0.1246 mg/L PBTK NA 50% Rat Human -DTXSID4052342 Css NA 0.5669 mg/L PBTK NA 95% Rat Human -DTXSID4052502 Clint NA 3.013 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052502 Fup NA 0.0167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052502 Vd NA 3.081 L/kg 1compartment NA NA Human Human -DTXSID4052502 Days.Css NA 131 Days PBTK NA NA Human Human -DTXSID4052502 TK.Half.Life NA 551 hours 1compartment NA NA Human Human -DTXSID4052502 Css NA 22.86 mg/L 3compartmentss NA 50% Human Human -DTXSID4052502 Css NA 142.6 mg/L 3compartmentss NA 95% Human Human -DTXSID4052502 Css NA 15.83 mg/L PBTK NA 50% Human Human -DTXSID4052502 Css NA 94.1 mg/L PBTK NA 95% Human Human -DTXSID4052502 Clint NA 3.013 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052502 Fup NA 0.0167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052502 Vd NA 2.308 L/kg 1compartment NA NA Rat Human -DTXSID4052502 Days.Css NA 70 Days PBTK NA NA Rat Human -DTXSID4052502 TK.Half.Life NA 74.79 hours 1compartment NA NA Rat Human -DTXSID4052502 Css NA 12.59 mg/L 3compartmentss NA 50% Rat Human -DTXSID4052502 Css NA 59.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID4052502 Css NA 8.337 mg/L PBTK NA 50% Rat Human -DTXSID4052502 Css NA 37.98 mg/L PBTK NA 95% Rat Human -DTXSID4052506 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052506 Fup NA 0.8636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052506 Vd NA 1.201 L/kg 1compartment NA NA Human Human +DTXSID4052342 TK.Half.Life NA 2.057 hours 1compartment NA NA Rat Human +DTXSID4052342 Css NA 0.05664 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052342 Css NA 0.3323 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052342 Css NA 0.04681 mg/L PBTK NA 50% Rat Human +DTXSID4052342 Css NA 0.2061 mg/L PBTK NA 95% Rat Human +DTXSID4052502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052502 Fup 0.0441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052502 Vd NA 1.481 L/kg 1compartment NA NA Human Human +DTXSID4052502 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4052502 TK.Half.Life NA 7.599 hours 1compartment NA NA Human Human +DTXSID4052502 Css NA 0.6982 mg/L 3compartmentss NA 50% Human Human +DTXSID4052502 Css NA 6.048 mg/L 3compartmentss NA 95% Human Human +DTXSID4052502 Css NA 0.4446 mg/L PBTK NA 50% Human Human +DTXSID4052502 Css NA 3.616 mg/L PBTK NA 95% Human Human +DTXSID4052502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052502 Fup 0.0441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052502 Vd NA 1.111 L/kg 1compartment NA NA Rat Human +DTXSID4052502 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4052502 TK.Half.Life NA 2.947 hours 1compartment NA NA Rat Human +DTXSID4052502 Css NA 0.09132 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052502 Css NA 0.5984 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052502 Css NA 0.0564 mg/L PBTK NA 50% Rat Human +DTXSID4052502 Css NA 0.3544 mg/L PBTK NA 95% Rat Human +DTXSID4052506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052506 Fup 0.546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052506 Vd NA 0.904 L/kg 1compartment NA NA Human Human DTXSID4052506 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4052506 TK.Half.Life NA 9.459 hours 1compartment NA NA Human Human -DTXSID4052506 Css NA 0.8774 mg/L 3compartmentss NA 50% Human Human -DTXSID4052506 Css NA 5.547 mg/L 3compartmentss NA 95% Human Human -DTXSID4052506 Css NA 0.7914 mg/L PBTK NA 50% Human Human -DTXSID4052506 Css NA 3.771 mg/L PBTK NA 95% Human Human -DTXSID4052506 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052506 Fup NA 0.8636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052506 Vd NA 1.136 L/kg 1compartment NA NA Rat Human +DTXSID4052506 TK.Half.Life NA 0.8479 hours 1compartment NA NA Human Human +DTXSID4052506 Css NA 0.02833 mg/L 3compartmentss NA 50% Human Human +DTXSID4052506 Css NA 0.3087 mg/L 3compartmentss NA 95% Human Human +DTXSID4052506 Css NA 0.0229 mg/L PBTK NA 50% Human Human +DTXSID4052506 Css NA 0.21 mg/L PBTK NA 95% Human Human +DTXSID4052506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052506 Fup 0.546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052506 Vd NA 0.8534 L/kg 1compartment NA NA Rat Human DTXSID4052506 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4052506 TK.Half.Life NA 2.936 hours 1compartment NA NA Rat Human -DTXSID4052506 Css NA 0.225 mg/L 3compartmentss NA 50% Rat Human -DTXSID4052506 Css NA 1.383 mg/L 3compartmentss NA 95% Rat Human -DTXSID4052506 Css NA 0.1986 mg/L PBTK NA 50% Rat Human -DTXSID4052506 Css NA 0.8568 mg/L PBTK NA 95% Rat Human -DTXSID4052550 Clint NA 1.636 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052550 Fup NA 0.3667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052550 Vd NA 2.177 L/kg 1compartment NA NA Human Human -DTXSID4052550 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4052550 TK.Half.Life NA 18.54 hours 1compartment NA NA Human Human -DTXSID4052550 Css NA 0.8884 mg/L 3compartmentss NA 50% Human Human -DTXSID4052550 Css NA 3.869 mg/L 3compartmentss NA 95% Human Human -DTXSID4052550 Css NA 0.6978 mg/L PBTK NA 50% Human Human -DTXSID4052550 Css NA 2.715 mg/L PBTK NA 95% Human Human -DTXSID4052550 Clint NA 1.636 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052550 Fup NA 0.3667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052550 Vd NA 1.711 L/kg 1compartment NA NA Rat Human +DTXSID4052506 TK.Half.Life NA 0.3995 hours 1compartment NA NA Rat Human +DTXSID4052506 Css NA 0.0009964 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052506 Css NA 0.01236 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052506 Css NA 0.000808 mg/L PBTK NA 50% Rat Human +DTXSID4052506 Css NA 0.008449 mg/L PBTK NA 95% Rat Human +DTXSID4052550 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052550 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052550 Vd NA 1.06 L/kg 1compartment NA NA Human Human +DTXSID4052550 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4052550 TK.Half.Life NA 1.657 hours 1compartment NA NA Human Human +DTXSID4052550 Css NA 0.0976 mg/L 3compartmentss NA 50% Human Human +DTXSID4052550 Css NA 0.7103 mg/L 3compartmentss NA 95% Human Human +DTXSID4052550 Css NA 0.06913 mg/L PBTK NA 50% Human Human +DTXSID4052550 Css NA 0.4697 mg/L PBTK NA 95% Human Human +DTXSID4052550 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052550 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052550 Vd NA 0.8771 L/kg 1compartment NA NA Rat Human DTXSID4052550 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4052550 TK.Half.Life NA 5.165 hours 1compartment NA NA Rat Human -DTXSID4052550 Css NA 0.3902 mg/L 3compartmentss NA 50% Rat Human -DTXSID4052550 Css NA 1.253 mg/L 3compartmentss NA 95% Rat Human -DTXSID4052550 Css NA 0.2973 mg/L PBTK NA 50% Rat Human -DTXSID4052550 Css NA 0.813 mg/L PBTK NA 95% Rat Human -DTXSID4052554 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052554 Fup NA 0.1975 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4052554 Vd NA 0.8279 L/kg 1compartment NA NA Human Human -DTXSID4052554 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID4052554 TK.Half.Life NA 28.91 hours 1compartment NA NA Human Human -DTXSID4052554 Css NA 4.088 mg/L 3compartmentss NA 50% Human Human -DTXSID4052554 Css NA 14.65 mg/L 3compartmentss NA 95% Human Human -DTXSID4052554 Css NA 2.845 mg/L PBTK NA 50% Human Human -DTXSID4052554 Css NA 9.178 mg/L PBTK NA 95% Human Human -DTXSID4052554 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052554 Fup NA 0.1975 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4052554 Vd NA 0.7036 L/kg 1compartment NA NA Rat Human +DTXSID4052550 TK.Half.Life NA 0.7209 hours 1compartment NA NA Rat Human +DTXSID4052550 Css NA 0.0123 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052550 Css NA 0.06852 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052550 Css NA 0.008714 mg/L PBTK NA 50% Rat Human +DTXSID4052550 Css NA 0.04554 mg/L PBTK NA 95% Rat Human +DTXSID4052554 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052554 Fup 0.0938 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052554 Vd NA 0.2486 L/kg 1compartment NA NA Human Human +DTXSID4052554 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4052554 TK.Half.Life NA 1.699 hours 1compartment NA NA Human Human +DTXSID4052554 Css NA 1.018 mg/L 3compartmentss NA 50% Human Human +DTXSID4052554 Css NA 7.023 mg/L 3compartmentss NA 95% Human Human +DTXSID4052554 Css NA 0.6166 mg/L PBTK NA 50% Human Human +DTXSID4052554 Css NA 4.182 mg/L PBTK NA 95% Human Human +DTXSID4052554 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052554 Fup 0.0938 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052554 Vd NA 0.254 L/kg 1compartment NA NA Rat Human DTXSID4052554 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4052554 TK.Half.Life NA 7.979 hours 1compartment NA NA Rat Human -DTXSID4052554 Css NA 1.13 mg/L 3compartmentss NA 50% Rat Human -DTXSID4052554 Css NA 3.396 mg/L 3compartmentss NA 95% Rat Human -DTXSID4052554 Css NA 0.7448 mg/L PBTK NA 50% Rat Human -DTXSID4052554 Css NA 1.986 mg/L PBTK NA 95% Rat Human -DTXSID4057631 Clint NA 1.503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057631 Fup NA 0.0555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057631 Vd NA 2.151 L/kg 1compartment NA NA Human Human -DTXSID4057631 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID4057631 TK.Half.Life NA 114.9 hours 1compartment NA NA Human Human -DTXSID4057631 Css NA 7.864 mg/L 3compartmentss NA 50% Human Human -DTXSID4057631 Css NA 35.85 mg/L 3compartmentss NA 95% Human Human -DTXSID4057631 Css NA 5.24 mg/L PBTK NA 50% Human Human -DTXSID4057631 Css NA 22.17 mg/L PBTK NA 95% Human Human -DTXSID4057631 Clint NA 1.503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057631 Fup NA 0.0555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057631 Vd NA 1.615 L/kg 1compartment NA NA Rat Human -DTXSID4057631 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID4057631 TK.Half.Life NA 29.25 hours 1compartment NA NA Rat Human -DTXSID4057631 Css NA 3.606 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057631 Css NA 12.66 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057631 Css NA 2.265 mg/L PBTK NA 50% Rat Human -DTXSID4057631 Css NA 7.321 mg/L PBTK NA 95% Rat Human -DTXSID4057633 Clint NA 38.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057633 Fup NA 0.0294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057633 Vd NA 2.498 L/kg 1compartment NA NA Human Human -DTXSID4057633 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4057633 TK.Half.Life NA 14.75 hours 1compartment NA NA Human Human -DTXSID4057633 Css NA 0.7808 mg/L 3compartmentss NA 50% Human Human -DTXSID4057633 Css NA 5.663 mg/L 3compartmentss NA 95% Human Human -DTXSID4057633 Css NA 0.5187 mg/L PBTK NA 50% Human Human -DTXSID4057633 Css NA 3.639 mg/L PBTK NA 95% Human Human -DTXSID4057633 Clint NA 38.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057633 Fup NA 0.0294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057633 Vd NA 1.875 L/kg 1compartment NA NA Rat Human +DTXSID4052554 TK.Half.Life NA 1.061 hours 1compartment NA NA Rat Human +DTXSID4052554 Css NA 0.1264 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052554 Css NA 0.6374 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052554 Css NA 0.07444 mg/L PBTK NA 50% Rat Human +DTXSID4052554 Css NA 0.3633 mg/L PBTK NA 95% Rat Human +DTXSID4052635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052635 Fup 0.0409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052635 Vd NA 0.9752 L/kg 1compartment NA NA Human Human +DTXSID4052635 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4052635 TK.Half.Life NA 4.933 hours 1compartment NA NA Human Human +DTXSID4052635 Css NA 0.7432 mg/L 3compartmentss NA 50% Human Human +DTXSID4052635 Css NA 6.77 mg/L 3compartmentss NA 95% Human Human +DTXSID4052635 Css NA 0.4605 mg/L PBTK NA 50% Human Human +DTXSID4052635 Css NA 4.091 mg/L PBTK NA 95% Human Human +DTXSID4052635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052635 Fup 0.0409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052635 Vd NA 0.7409 L/kg 1compartment NA NA Rat Human +DTXSID4052635 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4052635 TK.Half.Life NA 2.177 hours 1compartment NA NA Rat Human +DTXSID4052635 Css NA 0.09787 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052635 Css NA 0.695 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052635 Css NA 0.05871 mg/L PBTK NA 50% Rat Human +DTXSID4052635 Css NA 0.4035 mg/L PBTK NA 95% Rat Human +DTXSID4052712 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052712 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052712 Vd NA 1.521 L/kg 1compartment NA NA Human Human +DTXSID4052712 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID4052712 TK.Half.Life NA 27.14 hours 1compartment NA NA Human Human +DTXSID4052712 Css NA 1.742 mg/L 3compartmentss NA 50% Human Human +DTXSID4052712 Css NA 7.9 mg/L 3compartmentss NA 95% Human Human +DTXSID4052712 Css NA 1.431 mg/L PBTK NA 50% Human Human +DTXSID4052712 Css NA 5.322 mg/L PBTK NA 95% Human Human +DTXSID4052712 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052712 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052712 Vd NA 1.27 L/kg 1compartment NA NA Rat Human +DTXSID4052712 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4052712 TK.Half.Life NA 6.57 hours 1compartment NA NA Rat Human +DTXSID4052712 Css NA 0.1112 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052712 Css NA 0.4246 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052712 Css NA 0.09126 mg/L PBTK NA 50% Rat Human +DTXSID4052712 Css NA 0.2738 mg/L PBTK NA 95% Rat Human +DTXSID4052714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052714 Fup 0.0573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052714 Vd NA 0.8854 L/kg 1compartment NA NA Human Human +DTXSID4052714 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4052714 TK.Half.Life NA 3.415 hours 1compartment NA NA Human Human +DTXSID4052714 Css NA 0.5034 mg/L 3compartmentss NA 50% Human Human +DTXSID4052714 Css NA 3.959 mg/L 3compartmentss NA 95% Human Human +DTXSID4052714 Css NA 0.3198 mg/L PBTK NA 50% Human Human +DTXSID4052714 Css NA 2.408 mg/L PBTK NA 95% Human Human +DTXSID4052714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052714 Fup 0.0573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052714 Vd NA 0.6939 L/kg 1compartment NA NA Rat Human +DTXSID4052714 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4052714 TK.Half.Life NA 1.561 hours 1compartment NA NA Rat Human +DTXSID4052714 Css NA 0.0651 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052714 Css NA 0.4051 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052714 Css NA 0.04043 mg/L PBTK NA 50% Rat Human +DTXSID4052714 Css NA 0.2373 mg/L PBTK NA 95% Rat Human +DTXSID4052845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052845 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4052845 Vd NA 0.7258 L/kg 1compartment NA NA Human Human +DTXSID4052845 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4052845 TK.Half.Life NA 0.9684 hours 1compartment NA NA Human Human +DTXSID4052845 Css NA 0.07125 mg/L 3compartmentss NA 50% Human Human +DTXSID4052845 Css NA 0.5461 mg/L 3compartmentss NA 95% Human Human +DTXSID4052845 Css NA 0.05572 mg/L PBTK NA 50% Human Human +DTXSID4052845 Css NA 0.3817 mg/L PBTK NA 95% Human Human +DTXSID4052845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052845 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4052845 Vd NA 0.7218 L/kg 1compartment NA NA Rat Human +DTXSID4052845 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4052845 TK.Half.Life NA 0.5283 hours 1compartment NA NA Rat Human +DTXSID4052845 Css NA 0.009001 mg/L 3compartmentss NA 50% Rat Human +DTXSID4052845 Css NA 0.05315 mg/L 3compartmentss NA 95% Rat Human +DTXSID4052845 Css NA 0.007074 mg/L PBTK NA 50% Rat Human +DTXSID4052845 Css NA 0.03725 mg/L PBTK NA 95% Rat Human +DTXSID4057631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057631 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057631 Vd NA 2.349 L/kg 1compartment NA NA Human Human +DTXSID4057631 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4057631 TK.Half.Life NA 7.542 hours 1compartment NA NA Human Human +DTXSID4057631 Css NA 0.3282 mg/L 3compartmentss NA 50% Human Human +DTXSID4057631 Css NA 2.248 mg/L 3compartmentss NA 95% Human Human +DTXSID4057631 Css NA 0.2267 mg/L PBTK NA 50% Human Human +DTXSID4057631 Css NA 1.467 mg/L PBTK NA 95% Human Human +DTXSID4057631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057631 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057631 Vd NA 1.784 L/kg 1compartment NA NA Rat Human +DTXSID4057631 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4057631 TK.Half.Life NA 2.203 hours 1compartment NA NA Rat Human +DTXSID4057631 Css NA 0.04168 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057631 Css NA 0.2226 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057631 Css NA 0.02883 mg/L PBTK NA 50% Rat Human +DTXSID4057631 Css NA 0.1461 mg/L PBTK NA 95% Rat Human +DTXSID4057633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057633 Fup 0.0757 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057633 Vd NA 2.067 L/kg 1compartment NA NA Human Human +DTXSID4057633 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4057633 TK.Half.Life NA 8.33 hours 1compartment NA NA Human Human +DTXSID4057633 Css NA 0.4726 mg/L 3compartmentss NA 50% Human Human +DTXSID4057633 Css NA 3.241 mg/L 3compartmentss NA 95% Human Human +DTXSID4057633 Css NA 0.3205 mg/L PBTK NA 50% Human Human +DTXSID4057633 Css NA 2.077 mg/L PBTK NA 95% Human Human +DTXSID4057633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057633 Fup 0.0757 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057633 Vd NA 1.58 L/kg 1compartment NA NA Rat Human DTXSID4057633 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057633 TK.Half.Life NA 3.84 hours 1compartment NA NA Rat Human -DTXSID4057633 Css NA 0.4302 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057633 Css NA 2.564 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057633 Css NA 0.2724 mg/L PBTK NA 50% Rat Human -DTXSID4057633 Css NA 1.544 mg/L PBTK NA 95% Rat Human -DTXSID4057635 Clint NA 75.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057635 Fup NA 0.1531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057635 Vd NA 0.554 L/kg 1compartment NA NA Human Human +DTXSID4057633 TK.Half.Life NA 2.783 hours 1compartment NA NA Rat Human +DTXSID4057633 Css NA 0.06123 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057633 Css NA 0.3313 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057633 Css NA 0.04057 mg/L PBTK NA 50% Rat Human +DTXSID4057633 Css NA 0.2108 mg/L PBTK NA 95% Rat Human +DTXSID4057635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057635 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057635 Vd NA 0.9926 L/kg 1compartment NA NA Human Human DTXSID4057635 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057635 TK.Half.Life NA 0.6527 hours 1compartment NA NA Human Human -DTXSID4057635 Css NA 0.05162 mg/L 3compartmentss NA 50% Human Human -DTXSID4057635 Css NA 0.4195 mg/L 3compartmentss NA 95% Human Human -DTXSID4057635 Css NA 0.03312 mg/L PBTK NA 50% Human Human -DTXSID4057635 Css NA 0.2565 mg/L PBTK NA 95% Human Human -DTXSID4057635 Clint NA 75.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057635 Fup NA 0.1531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057635 Vd NA 0.4756 L/kg 1compartment NA NA Rat Human +DTXSID4057635 TK.Half.Life NA 1.144 hours 1compartment NA NA Human Human +DTXSID4057635 Css NA 0.0532 mg/L 3compartmentss NA 50% Human Human +DTXSID4057635 Css NA 0.4127 mg/L 3compartmentss NA 95% Human Human +DTXSID4057635 Css NA 0.0401 mg/L PBTK NA 50% Human Human +DTXSID4057635 Css NA 0.2787 mg/L PBTK NA 95% Human Human +DTXSID4057635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057635 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057635 Vd NA 0.8433 L/kg 1compartment NA NA Rat Human DTXSID4057635 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057635 TK.Half.Life NA 0.2803 hours 1compartment NA NA Rat Human -DTXSID4057635 Css NA 0.02861 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057635 Css NA 0.1905 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057635 Css NA 0.01747 mg/L PBTK NA 50% Rat Human -DTXSID4057635 Css NA 0.1099 mg/L PBTK NA 95% Rat Human -DTXSID4057637 Clint NA 12.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057637 Fup NA 0.4937 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057637 Vd NA 0.9912 L/kg 1compartment NA NA Human Human +DTXSID4057635 TK.Half.Life NA 0.4899 hours 1compartment NA NA Rat Human +DTXSID4057635 Css NA 0.00646 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057635 Css NA 0.03817 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057635 Css NA 0.004946 mg/L PBTK NA 50% Rat Human +DTXSID4057635 Css NA 0.02583 mg/L PBTK NA 95% Rat Human +DTXSID4057637 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057637 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057637 Vd NA 0.8852 L/kg 1compartment NA NA Human Human DTXSID4057637 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057637 TK.Half.Life NA 1.192 hours 1compartment NA NA Human Human -DTXSID4057637 Css NA 0.06823 mg/L 3compartmentss NA 50% Human Human -DTXSID4057637 Css NA 0.576 mg/L 3compartmentss NA 95% Human Human -DTXSID4057637 Css NA 0.05538 mg/L PBTK NA 50% Human Human -DTXSID4057637 Css NA 0.4009 mg/L PBTK NA 95% Human Human -DTXSID4057637 Clint NA 12.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057637 Fup NA 0.4937 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057637 Vd NA 0.9047 L/kg 1compartment NA NA Rat Human +DTXSID4057637 TK.Half.Life NA 0.9533 hours 1compartment NA NA Human Human +DTXSID4057637 Css NA 0.04554 mg/L 3compartmentss NA 50% Human Human +DTXSID4057637 Css NA 0.368 mg/L 3compartmentss NA 95% Human Human +DTXSID4057637 Css NA 0.03528 mg/L PBTK NA 50% Human Human +DTXSID4057637 Css NA 0.2579 mg/L PBTK NA 95% Human Human +DTXSID4057637 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057637 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057637 Vd NA 0.811 L/kg 1compartment NA NA Rat Human DTXSID4057637 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057637 TK.Half.Life NA 0.5663 hours 1compartment NA NA Rat Human -DTXSID4057637 Css NA 0.03492 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057637 Css NA 0.2372 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057637 Css NA 0.02719 mg/L PBTK NA 50% Rat Human -DTXSID4057637 Css NA 0.1572 mg/L PBTK NA 95% Rat Human -DTXSID4057639 Clint NA 106.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057639 Fup NA 0.1927 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057639 Vd NA 0.344 L/kg 1compartment NA NA Human Human -DTXSID4057639 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057639 TK.Half.Life NA 0.3526 hours 1compartment NA NA Human Human -DTXSID4057639 Css NA 0.0243 mg/L 3compartmentss NA 50% Human Human -DTXSID4057639 Css NA 0.1806 mg/L 3compartmentss NA 95% Human Human -DTXSID4057639 Css NA 0.01583 mg/L PBTK NA 50% Human Human -DTXSID4057639 Css NA 0.1152 mg/L PBTK NA 95% Human Human -DTXSID4057639 Clint NA 106.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057639 Fup NA 0.1927 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057639 Vd NA 0.3499 L/kg 1compartment NA NA Rat Human +DTXSID4057637 TK.Half.Life NA 0.4443 hours 1compartment NA NA Rat Human +DTXSID4057637 Css NA 0.005584 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057637 Css NA 0.03607 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057637 Css NA 0.004353 mg/L PBTK NA 50% Rat Human +DTXSID4057637 Css NA 0.02485 mg/L PBTK NA 95% Rat Human +DTXSID4057639 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057639 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057639 Vd NA 0.4979 L/kg 1compartment NA NA Human Human +DTXSID4057639 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4057639 TK.Half.Life NA 9.912 hours 1compartment NA NA Human Human +DTXSID4057639 Css NA 1.2 mg/L 3compartmentss NA 50% Human Human +DTXSID4057639 Css NA 5.205 mg/L 3compartmentss NA 95% Human Human +DTXSID4057639 Css NA 0.8741 mg/L PBTK NA 50% Human Human +DTXSID4057639 Css NA 3.312 mg/L PBTK NA 95% Human Human +DTXSID4057639 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057639 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057639 Vd NA 0.5033 L/kg 1compartment NA NA Rat Human DTXSID4057639 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057639 TK.Half.Life NA 0.1714 hours 1compartment NA NA Rat Human -DTXSID4057639 Css NA 0.01349 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057639 Css NA 0.07738 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057639 Css NA 0.008331 mg/L PBTK NA 50% Rat Human -DTXSID4057639 Css NA 0.04694 mg/L PBTK NA 95% Rat Human -DTXSID4057681 Clint NA 640 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057681 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057681 Vd NA 1.666 L/kg 1compartment NA NA Human Human -DTXSID4057681 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057681 TK.Half.Life NA 2.478 hours 1compartment NA NA Human Human -DTXSID4057681 Css NA 0.1018 mg/L 3compartmentss NA 50% Human Human -DTXSID4057681 Css NA 0.9563 mg/L 3compartmentss NA 95% Human Human -DTXSID4057681 Css NA 0.0638 mg/L PBTK NA 50% Human Human -DTXSID4057681 Css NA 0.5851 mg/L PBTK NA 95% Human Human -DTXSID4057681 Clint NA 640 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057681 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057681 Vd NA 1.233 L/kg 1compartment NA NA Rat Human +DTXSID4057639 TK.Half.Life NA 3.413 hours 1compartment NA NA Rat Human +DTXSID4057639 Css NA 0.006443 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057639 Css NA 0.0289 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057639 Css NA 0.004467 mg/L PBTK NA 50% Rat Human +DTXSID4057639 Css NA 0.01755 mg/L PBTK NA 95% Rat Human +DTXSID4057681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057681 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057681 Vd NA 2.855 L/kg 1compartment NA NA Human Human +DTXSID4057681 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4057681 TK.Half.Life NA 16.77 hours 1compartment NA NA Human Human +DTXSID4057681 Css NA 0.5702 mg/L 3compartmentss NA 50% Human Human +DTXSID4057681 Css NA 3.756 mg/L 3compartmentss NA 95% Human Human +DTXSID4057681 Css NA 0.3988 mg/L PBTK NA 50% Human Human +DTXSID4057681 Css NA 2.498 mg/L PBTK NA 95% Human Human +DTXSID4057681 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057681 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057681 Vd NA 2.159 L/kg 1compartment NA NA Rat Human DTXSID4057681 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057681 TK.Half.Life NA 0.8521 hours 1compartment NA NA Rat Human -DTXSID4057681 Css NA 0.05872 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057681 Css NA 0.4453 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057681 Css NA 0.03442 mg/L PBTK NA 50% Rat Human -DTXSID4057681 Css NA 0.2515 mg/L PBTK NA 95% Rat Human -DTXSID4057683 Clint NA 19.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057683 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057683 Vd NA 0.7918 L/kg 1compartment NA NA Human Human +DTXSID4057681 TK.Half.Life NA 3.485 hours 1compartment NA NA Rat Human +DTXSID4057681 Css NA 0.02826 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057681 Css NA 0.1921 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057681 Css NA 0.01938 mg/L PBTK NA 50% Rat Human +DTXSID4057681 Css NA 0.126 mg/L PBTK NA 95% Rat Human +DTXSID4057683 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057683 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057683 Vd NA 1.362 L/kg 1compartment NA NA Human Human DTXSID4057683 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057683 TK.Half.Life NA 2.128 hours 1compartment NA NA Human Human -DTXSID4057683 Css NA 0.3076 mg/L 3compartmentss NA 50% Human Human -DTXSID4057683 Css NA 2.425 mg/L 3compartmentss NA 95% Human Human -DTXSID4057683 Css NA 0.1962 mg/L PBTK NA 50% Human Human -DTXSID4057683 Css NA 1.486 mg/L PBTK NA 95% Human Human -DTXSID4057683 Clint NA 19.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057683 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057683 Vd NA 0.6409 L/kg 1compartment NA NA Rat Human +DTXSID4057683 TK.Half.Life NA 5.311 hours 1compartment NA NA Human Human +DTXSID4057683 Css NA 0.3838 mg/L 3compartmentss NA 50% Human Human +DTXSID4057683 Css NA 2.222 mg/L 3compartmentss NA 95% Human Human +DTXSID4057683 Css NA 0.2744 mg/L PBTK NA 50% Human Human +DTXSID4057683 Css NA 1.452 mg/L PBTK NA 95% Human Human +DTXSID4057683 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057683 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057683 Vd NA 1.084 L/kg 1compartment NA NA Rat Human DTXSID4057683 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057683 TK.Half.Life NA 0.9872 hours 1compartment NA NA Rat Human -DTXSID4057683 Css NA 0.1698 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057683 Css NA 1.025 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057683 Css NA 0.1029 mg/L PBTK NA 50% Rat Human -DTXSID4057683 Css NA 0.5876 mg/L PBTK NA 95% Rat Human -DTXSID4057685 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057685 Fup NA 0.0972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057685 Vd NA 0.2748 L/kg 1compartment NA NA Human Human -DTXSID4057685 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4057685 TK.Half.Life NA 18.33 hours 1compartment NA NA Human Human -DTXSID4057685 Css NA 10.57 mg/L 3compartmentss NA 50% Human Human -DTXSID4057685 Css NA 48.95 mg/L 3compartmentss NA 95% Human Human -DTXSID4057685 Css NA 6.455 mg/L PBTK NA 50% Human Human -DTXSID4057685 Css NA 28.54 mg/L PBTK NA 95% Human Human -DTXSID4057685 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057685 Fup NA 0.0972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057685 Vd NA 0.264 L/kg 1compartment NA NA Rat Human -DTXSID4057685 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057685 TK.Half.Life NA 5.991 hours 1compartment NA NA Rat Human -DTXSID4057685 Css NA 3.008 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057685 Css NA 11.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057685 Css NA 1.713 mg/L PBTK NA 50% Rat Human -DTXSID4057685 Css NA 6.078 mg/L PBTK NA 95% Rat Human -DTXSID4057687 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057687 Fup NA 0.8828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057687 Vd NA 0.5235 L/kg 1compartment NA NA Human Human +DTXSID4057683 TK.Half.Life NA 2.186 hours 1compartment NA NA Rat Human +DTXSID4057683 Css NA 0.04564 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057683 Css NA 0.1885 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057683 Css NA 0.03223 mg/L PBTK NA 50% Rat Human +DTXSID4057683 Css NA 0.1231 mg/L PBTK NA 95% Rat Human +DTXSID4057685 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057685 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057685 Vd NA 1.464 L/kg 1compartment NA NA Human Human +DTXSID4057685 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID4057685 TK.Half.Life NA 87.93 hours 1compartment NA NA Human Human +DTXSID4057685 Css NA 7.652 mg/L 3compartmentss NA 50% Human Human +DTXSID4057685 Css NA 32.2 mg/L 3compartmentss NA 95% Human Human +DTXSID4057685 Css NA 5.238 mg/L PBTK NA 50% Human Human +DTXSID4057685 Css NA 19.78 mg/L PBTK NA 95% Human Human +DTXSID4057685 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057685 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057685 Vd NA 1.137 L/kg 1compartment NA NA Rat Human +DTXSID4057685 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4057685 TK.Half.Life NA 18.8 hours 1compartment NA NA Rat Human +DTXSID4057685 Css NA 0.4945 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057685 Css NA 1.734 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057685 Css NA 0.3317 mg/L PBTK NA 50% Rat Human +DTXSID4057685 Css NA 1.033 mg/L PBTK NA 95% Rat Human +DTXSID4057687 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057687 Fup 0.482 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057687 Vd NA 0.3774 L/kg 1compartment NA NA Human Human DTXSID4057687 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057687 TK.Half.Life NA 3.838 hours 1compartment NA NA Human Human -DTXSID4057687 Css NA 1.028 mg/L 3compartmentss NA 50% Human Human -DTXSID4057687 Css NA 5.663 mg/L 3compartmentss NA 95% Human Human -DTXSID4057687 Css NA 0.7758 mg/L PBTK NA 50% Human Human -DTXSID4057687 Css NA 3.549 mg/L PBTK NA 95% Human Human -DTXSID4057687 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057687 Fup NA 0.8828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057687 Vd NA 0.5432 L/kg 1compartment NA NA Rat Human +DTXSID4057687 TK.Half.Life NA 5.067 hours 1compartment NA NA Human Human +DTXSID4057687 Css NA 1.572 mg/L 3compartmentss NA 50% Human Human +DTXSID4057687 Css NA 7.378 mg/L 3compartmentss NA 95% Human Human +DTXSID4057687 Css NA 1.102 mg/L PBTK NA 50% Human Human +DTXSID4057687 Css NA 4.59 mg/L PBTK NA 95% Human Human +DTXSID4057687 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057687 Fup 0.482 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057687 Vd NA 0.3902 L/kg 1compartment NA NA Rat Human DTXSID4057687 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057687 TK.Half.Life NA 1.357 hours 1compartment NA NA Rat Human -DTXSID4057687 Css NA 0.2639 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057687 Css NA 1.394 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057687 Css NA 0.1917 mg/L PBTK NA 50% Rat Human -DTXSID4057687 Css NA 0.8141 mg/L PBTK NA 95% Rat Human -DTXSID4057689 Clint NA 46.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057689 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057689 Vd NA 2.828 L/kg 1compartment NA NA Human Human -DTXSID4057689 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID4057689 TK.Half.Life NA 23.01 hours 1compartment NA NA Human Human -DTXSID4057689 Css NA 1.028 mg/L 3compartmentss NA 50% Human Human -DTXSID4057689 Css NA 7.255 mg/L 3compartmentss NA 95% Human Human -DTXSID4057689 Css NA 0.6968 mg/L PBTK NA 50% Human Human -DTXSID4057689 Css NA 4.738 mg/L PBTK NA 95% Human Human -DTXSID4057689 Clint NA 46.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057689 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057689 Vd NA 2.115 L/kg 1compartment NA NA Rat Human -DTXSID4057689 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4057689 TK.Half.Life NA 4.581 hours 1compartment NA NA Rat Human -DTXSID4057689 Css NA 0.5759 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057689 Css NA 3.262 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057689 Css NA 0.3715 mg/L PBTK NA 50% Rat Human -DTXSID4057689 Css NA 2.002 mg/L PBTK NA 95% Rat Human +DTXSID4057687 TK.Half.Life NA 1.785 hours 1compartment NA NA Rat Human +DTXSID4057687 Css NA 0.1004 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057687 Css NA 0.4143 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057687 Css NA 0.06908 mg/L PBTK NA 50% Rat Human +DTXSID4057687 Css NA 0.2468 mg/L PBTK NA 95% Rat Human +DTXSID4057689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057689 Fup 0.00721 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057689 Vd NA 3.087 L/kg 1compartment NA NA Human Human +DTXSID4057689 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID4057689 TK.Half.Life NA 92.27 hours 1compartment NA NA Human Human +DTXSID4057689 Css NA 3.542 mg/L 3compartmentss NA 50% Human Human +DTXSID4057689 Css NA 21.79 mg/L 3compartmentss NA 95% Human Human +DTXSID4057689 Css NA 2.442 mg/L PBTK NA 50% Human Human +DTXSID4057689 Css NA 14.65 mg/L PBTK NA 95% Human Human +DTXSID4057689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057689 Fup 0.00721 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057689 Vd NA 2.311 L/kg 1compartment NA NA Rat Human +DTXSID4057689 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID4057689 TK.Half.Life NA 12.94 hours 1compartment NA NA Rat Human +DTXSID4057689 Css NA 0.4676 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057689 Css NA 2.355 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057689 Css NA 0.3196 mg/L PBTK NA 50% Rat Human +DTXSID4057689 Css NA 1.623 mg/L PBTK NA 95% Rat Human DTXSID4057710 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID4057710 Fup NA 0.0194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057710 Vd NA 0.2142 L/kg 1compartment NA NA Human Human -DTXSID4057710 Days.Css NA 14 Days PBTK NA NA Human Human -DTXSID4057710 TK.Half.Life NA 71.45 hours 1compartment NA NA Human Human -DTXSID4057710 Css NA 56.88 mg/L 3compartmentss NA 50% Human Human -DTXSID4057710 Css NA 352.8 mg/L 3compartmentss NA 95% Human Human -DTXSID4057710 Css NA 33.48 mg/L PBTK NA 50% Human Human -DTXSID4057710 Css NA 204.1 mg/L PBTK NA 95% Human Human +DTXSID4057710 Vd NA 0.1839 L/kg 1compartment NA NA Human Human +DTXSID4057710 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID4057710 TK.Half.Life NA 61.34 hours 1compartment NA NA Human Human +DTXSID4057710 Css NA 48.68 mg/L 3compartmentss NA 50% Human Human +DTXSID4057710 Css NA 297.9 mg/L 3compartmentss NA 95% Human Human +DTXSID4057710 Css NA 28.53 mg/L PBTK NA 50% Human Human +DTXSID4057710 Css NA 173.3 mg/L PBTK NA 95% Human Human DTXSID4057710 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID4057710 Fup NA 0.0194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057710 Vd NA 0.2104 L/kg 1compartment NA NA Rat Human +DTXSID4057710 Vd NA 0.1835 L/kg 1compartment NA NA Rat Human DTXSID4057710 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4057710 TK.Half.Life NA 23.91 hours 1compartment NA NA Rat Human -DTXSID4057710 Css NA 16.38 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057710 Css NA 86.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057710 Css NA 9.022 mg/L PBTK NA 50% Rat Human -DTXSID4057710 Css NA 46.7 mg/L PBTK NA 95% Rat Human -DTXSID4057712 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID4057710 TK.Half.Life NA 20.85 hours 1compartment NA NA Rat Human +DTXSID4057710 Css NA 0.92 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057710 Css NA 7.607 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057710 Css NA 0.5088 mg/L PBTK NA 50% Rat Human +DTXSID4057710 Css NA 4.231 mg/L PBTK NA 95% Rat Human +DTXSID4057712 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID4057712 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID4057712 Vd NA 0.6986 L/kg 1compartment NA NA Human Human +DTXSID4057712 Vd NA 0.5901 L/kg 1compartment NA NA Human Human DTXSID4057712 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057712 TK.Half.Life NA 6.472 hours 1compartment NA NA Human Human -DTXSID4057712 Css NA 1.093 mg/L 3compartmentss NA 50% Human Human -DTXSID4057712 Css NA 7.092 mg/L 3compartmentss NA 95% Human Human -DTXSID4057712 Css NA 0.8832 mg/L PBTK NA 50% Human Human -DTXSID4057712 Css NA 4.456 mg/L PBTK NA 95% Human Human -DTXSID4057712 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID4057712 TK.Half.Life NA 5.454 hours 1compartment NA NA Human Human +DTXSID4057712 Css NA 0.6088 mg/L 3compartmentss NA 50% Human Human +DTXSID4057712 Css NA 4.114 mg/L 3compartmentss NA 95% Human Human +DTXSID4057712 Css NA 0.477 mg/L PBTK NA 50% Human Human +DTXSID4057712 Css NA 2.595 mg/L PBTK NA 95% Human Human +DTXSID4057712 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID4057712 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID4057712 Vd NA 0.7179 L/kg 1compartment NA NA Rat Human +DTXSID4057712 Vd NA 0.6257 L/kg 1compartment NA NA Rat Human DTXSID4057712 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057712 TK.Half.Life NA 2.263 hours 1compartment NA NA Rat Human -DTXSID4057712 Css NA 0.2857 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057712 Css NA 1.776 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057712 Css NA 0.2226 mg/L PBTK NA 50% Rat Human -DTXSID4057712 Css NA 1.049 mg/L PBTK NA 95% Rat Human -DTXSID4057714 Clint NA 8.518 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057714 Fup NA 0.0645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057714 Vd NA 2.659 L/kg 1compartment NA NA Human Human -DTXSID4057714 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID4057714 TK.Half.Life NA 42.97 hours 1compartment NA NA Human Human -DTXSID4057714 Css NA 2.114 mg/L 3compartmentss NA 50% Human Human -DTXSID4057714 Css NA 12.52 mg/L 3compartmentss NA 95% Human Human -DTXSID4057714 Css NA 1.444 mg/L PBTK NA 50% Human Human -DTXSID4057714 Css NA 8.244 mg/L PBTK NA 95% Human Human -DTXSID4057714 Clint NA 8.518 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057714 Fup NA 0.0645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057714 Vd NA 1.993 L/kg 1compartment NA NA Rat Human -DTXSID4057714 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID4057714 TK.Half.Life NA 9.297 hours 1compartment NA NA Rat Human -DTXSID4057714 Css NA 1.152 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057714 Css NA 5.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057714 Css NA 0.7473 mg/L PBTK NA 50% Rat Human -DTXSID4057714 Css NA 3.142 mg/L PBTK NA 95% Rat Human -DTXSID4057716 Clint NA 24.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057716 Fup NA 0.1152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057716 Vd NA 0.4368 L/kg 1compartment NA NA Human Human -DTXSID4057716 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057716 TK.Half.Life NA 0.9273 hours 1compartment NA NA Human Human -DTXSID4057716 Css NA 0.2129 mg/L 3compartmentss NA 50% Human Human -DTXSID4057716 Css NA 1.724 mg/L 3compartmentss NA 95% Human Human -DTXSID4057716 Css NA 0.1391 mg/L PBTK NA 50% Human Human -DTXSID4057716 Css NA 1.055 mg/L PBTK NA 95% Human Human -DTXSID4057716 Clint NA 24.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057716 Fup NA 0.1152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057716 Vd NA 0.4102 L/kg 1compartment NA NA Rat Human +DTXSID4057712 TK.Half.Life NA 1.97 hours 1compartment NA NA Rat Human +DTXSID4057712 Css NA 0.003235 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057712 Css NA 0.02152 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057712 Css NA 0.002454 mg/L PBTK NA 50% Rat Human +DTXSID4057712 Css NA 0.01297 mg/L PBTK NA 95% Rat Human +DTXSID4057714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057714 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057714 Vd NA 1.699 L/kg 1compartment NA NA Human Human +DTXSID4057714 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4057714 TK.Half.Life NA 19.13 hours 1compartment NA NA Human Human +DTXSID4057714 Css NA 1.737 mg/L 3compartmentss NA 50% Human Human +DTXSID4057714 Css NA 14.91 mg/L 3compartmentss NA 95% Human Human +DTXSID4057714 Css NA 1.09 mg/L PBTK NA 50% Human Human +DTXSID4057714 Css NA 9.121 mg/L PBTK NA 95% Human Human +DTXSID4057714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057714 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057714 Vd NA 1.257 L/kg 1compartment NA NA Rat Human +DTXSID4057714 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4057714 TK.Half.Life NA 6.876 hours 1compartment NA NA Rat Human +DTXSID4057714 Css NA 0.2283 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057714 Css NA 1.553 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057714 Css NA 0.14 mg/L PBTK NA 50% Rat Human +DTXSID4057714 Css NA 0.9252 mg/L PBTK NA 95% Rat Human +DTXSID4057716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057716 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057716 Vd NA 0.4364 L/kg 1compartment NA NA Human Human +DTXSID4057716 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4057716 TK.Half.Life NA 10.43 hours 1compartment NA NA Human Human +DTXSID4057716 Css NA 2.687 mg/L 3compartmentss NA 50% Human Human +DTXSID4057716 Css NA 10.32 mg/L 3compartmentss NA 95% Human Human +DTXSID4057716 Css NA 1.888 mg/L PBTK NA 50% Human Human +DTXSID4057716 Css NA 6.491 mg/L PBTK NA 95% Human Human +DTXSID4057716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057716 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057716 Vd NA 0.431 L/kg 1compartment NA NA Rat Human DTXSID4057716 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057716 TK.Half.Life NA 0.5052 hours 1compartment NA NA Rat Human -DTXSID4057716 Css NA 0.1192 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057716 Css NA 0.7299 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057716 Css NA 0.07338 mg/L PBTK NA 50% Rat Human -DTXSID4057716 Css NA 0.4184 mg/L PBTK NA 95% Rat Human -DTXSID4057718 Clint NA 3.682 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057718 Fup NA 0.368 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057718 Vd NA 0.7175 L/kg 1compartment NA NA Human Human +DTXSID4057716 TK.Half.Life NA 3.508 hours 1compartment NA NA Rat Human +DTXSID4057716 Css NA 0.1746 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057716 Css NA 0.561 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057716 Css NA 0.1203 mg/L PBTK NA 50% Rat Human +DTXSID4057716 Css NA 0.3395 mg/L PBTK NA 95% Rat Human +DTXSID4057718 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057718 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057718 Vd NA 0.6901 L/kg 1compartment NA NA Human Human DTXSID4057718 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057718 TK.Half.Life NA 2.185 hours 1compartment NA NA Human Human -DTXSID4057718 Css NA 0.2934 mg/L 3compartmentss NA 50% Human Human -DTXSID4057718 Css NA 1.712 mg/L 3compartmentss NA 95% Human Human -DTXSID4057718 Css NA 0.2172 mg/L PBTK NA 50% Human Human -DTXSID4057718 Css NA 1.128 mg/L PBTK NA 95% Human Human -DTXSID4057718 Clint NA 3.682 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057718 Fup NA 0.368 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057718 Vd NA 0.6696 L/kg 1compartment NA NA Rat Human +DTXSID4057718 TK.Half.Life NA 0.8061 hours 1compartment NA NA Human Human +DTXSID4057718 Css NA 0.05294 mg/L 3compartmentss NA 50% Human Human +DTXSID4057718 Css NA 0.399 mg/L 3compartmentss NA 95% Human Human +DTXSID4057718 Css NA 0.03906 mg/L PBTK NA 50% Human Human +DTXSID4057718 Css NA 0.2724 mg/L PBTK NA 95% Human Human +DTXSID4057718 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057718 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057718 Vd NA 0.6504 L/kg 1compartment NA NA Rat Human DTXSID4057718 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057718 TK.Half.Life NA 1.128 hours 1compartment NA NA Rat Human -DTXSID4057718 Css NA 0.1404 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057718 Css NA 0.6367 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057718 Css NA 0.09998 mg/L PBTK NA 50% Rat Human -DTXSID4057718 Css NA 0.3885 mg/L PBTK NA 95% Rat Human -DTXSID4057760 Clint NA 46.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057760 Fup NA 0.0806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057760 Vd NA 1.113 L/kg 1compartment NA NA Human Human +DTXSID4057718 TK.Half.Life NA 0.3929 hours 1compartment NA NA Rat Human +DTXSID4057718 Css NA 0.006638 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057718 Css NA 0.04252 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057718 Css NA 0.004857 mg/L PBTK NA 50% Rat Human +DTXSID4057718 Css NA 0.02722 mg/L PBTK NA 95% Rat Human +DTXSID4057760 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057760 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057760 Vd NA 2.267 L/kg 1compartment NA NA Human Human DTXSID4057760 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057760 TK.Half.Life NA 2.081 hours 1compartment NA NA Human Human -DTXSID4057760 Css NA 0.171 mg/L 3compartmentss NA 50% Human Human -DTXSID4057760 Css NA 1.402 mg/L 3compartmentss NA 95% Human Human -DTXSID4057760 Css NA 0.1117 mg/L PBTK NA 50% Human Human -DTXSID4057760 Css NA 0.8756 mg/L PBTK NA 95% Human Human -DTXSID4057760 Clint NA 46.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057760 Fup NA 0.0806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057760 Vd NA 0.9335 L/kg 1compartment NA NA Rat Human +DTXSID4057760 TK.Half.Life NA 3.555 hours 1compartment NA NA Human Human +DTXSID4057760 Css NA 0.09784 mg/L 3compartmentss NA 50% Human Human +DTXSID4057760 Css NA 0.656 mg/L 3compartmentss NA 95% Human Human +DTXSID4057760 Css NA 0.07542 mg/L PBTK NA 50% Human Human +DTXSID4057760 Css NA 0.4673 mg/L PBTK NA 95% Human Human +DTXSID4057760 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057760 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057760 Vd NA 1.769 L/kg 1compartment NA NA Rat Human DTXSID4057760 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057760 TK.Half.Life NA 0.9502 hours 1compartment NA NA Rat Human -DTXSID4057760 Css NA 0.09703 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057760 Css NA 0.6396 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057760 Css NA 0.05979 mg/L PBTK NA 50% Rat Human -DTXSID4057760 Css NA 0.376 mg/L PBTK NA 95% Rat Human -DTXSID4057762 Clint NA 6.746 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057762 Fup NA 0.0348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057762 Vd NA 0.2138 L/kg 1compartment NA NA Human Human +DTXSID4057760 TK.Half.Life NA 1.148 hours 1compartment NA NA Rat Human +DTXSID4057760 Css NA 0.01221 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057760 Css NA 0.06221 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057760 Css NA 0.009465 mg/L PBTK NA 50% Rat Human +DTXSID4057760 Css NA 0.04492 mg/L PBTK NA 95% Rat Human +DTXSID4057762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057762 Fup 0.0905 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057762 Vd NA 0.3294 L/kg 1compartment NA NA Human Human DTXSID4057762 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057762 TK.Half.Life NA 3.44 hours 1compartment NA NA Human Human -DTXSID4057762 Css NA 2.941 mg/L 3compartmentss NA 50% Human Human -DTXSID4057762 Css NA 19.01 mg/L 3compartmentss NA 95% Human Human -DTXSID4057762 Css NA 1.744 mg/L PBTK NA 50% Human Human -DTXSID4057762 Css NA 11.13 mg/L PBTK NA 95% Human Human -DTXSID4057762 Clint NA 6.746 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057762 Fup NA 0.0348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057762 Vd NA 0.2098 L/kg 1compartment NA NA Rat Human +DTXSID4057762 TK.Half.Life NA 0.9132 hours 1compartment NA NA Human Human +DTXSID4057762 Css NA 0.3166 mg/L 3compartmentss NA 50% Human Human +DTXSID4057762 Css NA 2.496 mg/L 3compartmentss NA 95% Human Human +DTXSID4057762 Css NA 0.1986 mg/L PBTK NA 50% Human Human +DTXSID4057762 Css NA 1.515 mg/L PBTK NA 95% Human Human +DTXSID4057762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057762 Fup 0.0905 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057762 Vd NA 0.3199 L/kg 1compartment NA NA Rat Human DTXSID4057762 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057762 TK.Half.Life NA 2.134 hours 1compartment NA NA Rat Human -DTXSID4057762 Css NA 1.58 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057762 Css NA 7.908 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057762 Css NA 0.8768 mg/L PBTK NA 50% Rat Human -DTXSID4057762 Css NA 4.334 mg/L PBTK NA 95% Rat Human -DTXSID4057764 Clint NA 2.603 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057764 Fup NA 0.4127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057764 Vd NA 2.465 L/kg 1compartment NA NA Human Human +DTXSID4057762 TK.Half.Life NA 0.5328 hours 1compartment NA NA Rat Human +DTXSID4057762 Css NA 0.04135 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057762 Css NA 0.2586 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057762 Css NA 0.02529 mg/L PBTK NA 50% Rat Human +DTXSID4057762 Css NA 0.1506 mg/L PBTK NA 95% Rat Human +DTXSID4057764 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057764 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057764 Vd NA 0.4689 L/kg 1compartment NA NA Human Human DTXSID4057764 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057764 TK.Half.Life NA 9.332 hours 1compartment NA NA Human Human -DTXSID4057764 Css NA 0.3114 mg/L 3compartmentss NA 50% Human Human -DTXSID4057764 Css NA 1.85 mg/L 3compartmentss NA 95% Human Human -DTXSID4057764 Css NA 0.2974 mg/L PBTK NA 50% Human Human -DTXSID4057764 Css NA 1.422 mg/L PBTK NA 95% Human Human -DTXSID4057764 Clint NA 2.603 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057764 Fup NA 0.4127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057764 Vd NA 2.306 L/kg 1compartment NA NA Rat Human +DTXSID4057764 TK.Half.Life NA 0.8486 hours 1compartment NA NA Human Human +DTXSID4057764 Css NA 0.1428 mg/L 3compartmentss NA 50% Human Human +DTXSID4057764 Css NA 1.022 mg/L 3compartmentss NA 95% Human Human +DTXSID4057764 Css NA 0.1024 mg/L PBTK NA 50% Human Human +DTXSID4057764 Css NA 0.6576 mg/L PBTK NA 95% Human Human +DTXSID4057764 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057764 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057764 Vd NA 0.479 L/kg 1compartment NA NA Rat Human DTXSID4057764 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057764 TK.Half.Life NA 4.289 hours 1compartment NA NA Rat Human -DTXSID4057764 Css NA 0.1411 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057764 Css NA 0.6726 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057764 Css NA 0.1325 mg/L PBTK NA 50% Rat Human -DTXSID4057764 Css NA 0.4673 mg/L PBTK NA 95% Rat Human -DTXSID4057768 Clint NA 17.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057768 Fup NA 0.1879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057768 Vd NA 0.6121 L/kg 1compartment NA NA Human Human +DTXSID4057764 TK.Half.Life NA 0.4738 hours 1compartment NA NA Rat Human +DTXSID4057764 Css NA 0.01633 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057764 Css NA 0.09281 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057764 Css NA 0.01171 mg/L PBTK NA 50% Rat Human +DTXSID4057764 Css NA 0.05712 mg/L PBTK NA 95% Rat Human +DTXSID4057768 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057768 Fup 0.283 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057768 Vd NA 0.7664 L/kg 1compartment NA NA Human Human DTXSID4057768 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057768 TK.Half.Life NA 1.166 hours 1compartment NA NA Human Human -DTXSID4057768 Css NA 0.1499 mg/L 3compartmentss NA 50% Human Human -DTXSID4057768 Css NA 1.005 mg/L 3compartmentss NA 95% Human Human -DTXSID4057768 Css NA 0.1013 mg/L PBTK NA 50% Human Human -DTXSID4057768 Css NA 0.6509 mg/L PBTK NA 95% Human Human -DTXSID4057768 Clint NA 17.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057768 Fup NA 0.1879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057768 Vd NA 0.548 L/kg 1compartment NA NA Rat Human +DTXSID4057768 TK.Half.Life NA 2.053 hours 1compartment NA NA Human Human +DTXSID4057768 Css NA 0.2373 mg/L 3compartmentss NA 50% Human Human +DTXSID4057768 Css NA 1.498 mg/L 3compartmentss NA 95% Human Human +DTXSID4057768 Css NA 0.1696 mg/L PBTK NA 50% Human Human +DTXSID4057768 Css NA 0.9995 mg/L PBTK NA 95% Human Human +DTXSID4057768 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057768 Fup 0.283 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057768 Vd NA 0.6876 L/kg 1compartment NA NA Rat Human DTXSID4057768 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057768 TK.Half.Life NA 0.5859 hours 1compartment NA NA Rat Human -DTXSID4057768 Css NA 0.08198 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057768 Css NA 0.3986 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057768 Css NA 0.0525 mg/L PBTK NA 50% Rat Human -DTXSID4057768 Css NA 0.2441 mg/L PBTK NA 95% Rat Human -DTXSID4057841 Clint NA 11.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057841 Fup NA 0.3228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057841 Vd NA 1.144 L/kg 1compartment NA NA Human Human +DTXSID4057768 TK.Half.Life NA 1.038 hours 1compartment NA NA Rat Human +DTXSID4057768 Css NA 0.0282 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057768 Css NA 0.129 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057768 Css NA 0.0201 mg/L PBTK NA 50% Rat Human +DTXSID4057768 Css NA 0.08205 mg/L PBTK NA 95% Rat Human +DTXSID4057841 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057841 Fup 0.421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057841 Vd NA 1.107 L/kg 1compartment NA NA Human Human DTXSID4057841 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057841 TK.Half.Life NA 2.027 hours 1compartment NA NA Human Human -DTXSID4057841 Css NA 0.1309 mg/L 3compartmentss NA 50% Human Human -DTXSID4057841 Css NA 0.9116 mg/L 3compartmentss NA 95% Human Human -DTXSID4057841 Css NA 0.0977 mg/L PBTK NA 50% Human Human -DTXSID4057841 Css NA 0.6183 mg/L PBTK NA 95% Human Human -DTXSID4057841 Clint NA 11.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057841 Fup NA 0.3228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057841 Vd NA 0.9395 L/kg 1compartment NA NA Rat Human +DTXSID4057841 TK.Half.Life NA 2.267 hours 1compartment NA NA Human Human +DTXSID4057841 Css NA 0.1596 mg/L 3compartmentss NA 50% Human Human +DTXSID4057841 Css NA 1.078 mg/L 3compartmentss NA 95% Human Human +DTXSID4057841 Css NA 0.124 mg/L PBTK NA 50% Human Human +DTXSID4057841 Css NA 0.7374 mg/L PBTK NA 95% Human Human +DTXSID4057841 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057841 Fup 0.421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057841 Vd NA 0.9341 L/kg 1compartment NA NA Rat Human DTXSID4057841 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057841 TK.Half.Life NA 0.8694 hours 1compartment NA NA Rat Human -DTXSID4057841 Css NA 0.06928 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057841 Css NA 0.3445 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057841 Css NA 0.04966 mg/L PBTK NA 50% Rat Human -DTXSID4057841 Css NA 0.2235 mg/L PBTK NA 95% Rat Human -DTXSID4057843 Clint NA 3.658 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057843 Fup NA 0.3324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057843 Vd NA 1.353 L/kg 1compartment NA NA Human Human +DTXSID4057841 TK.Half.Life NA 1.006 hours 1compartment NA NA Rat Human +DTXSID4057841 Css NA 0.01844 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057841 Css NA 0.09564 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057841 Css NA 0.01434 mg/L PBTK NA 50% Rat Human +DTXSID4057841 Css NA 0.06326 mg/L PBTK NA 95% Rat Human +DTXSID4057843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057843 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057843 Vd NA 0.8408 L/kg 1compartment NA NA Human Human DTXSID4057843 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057843 TK.Half.Life NA 4.983 hours 1compartment NA NA Human Human -DTXSID4057843 Css NA 0.3606 mg/L 3compartmentss NA 50% Human Human -DTXSID4057843 Css NA 1.967 mg/L 3compartmentss NA 95% Human Human -DTXSID4057843 Css NA 0.2768 mg/L PBTK NA 50% Human Human -DTXSID4057843 Css NA 1.34 mg/L PBTK NA 95% Human Human -DTXSID4057843 Clint NA 3.658 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057843 Fup NA 0.3324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057843 Vd NA 1.115 L/kg 1compartment NA NA Rat Human +DTXSID4057843 TK.Half.Life NA 1.333 hours 1compartment NA NA Human Human +DTXSID4057843 Css NA 0.09886 mg/L 3compartmentss NA 50% Human Human +DTXSID4057843 Css NA 0.7105 mg/L 3compartmentss NA 95% Human Human +DTXSID4057843 Css NA 0.06909 mg/L PBTK NA 50% Human Human +DTXSID4057843 Css NA 0.4661 mg/L PBTK NA 95% Human Human +DTXSID4057843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057843 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057843 Vd NA 0.7158 L/kg 1compartment NA NA Rat Human DTXSID4057843 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057843 TK.Half.Life NA 2.074 hours 1compartment NA NA Rat Human -DTXSID4057843 Css NA 0.173 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057843 Css NA 0.7098 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057843 Css NA 0.1283 mg/L PBTK NA 50% Rat Human -DTXSID4057843 Css NA 0.4477 mg/L PBTK NA 95% Rat Human -DTXSID4057845 Clint NA 1.506 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057845 Fup NA 0.2594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057845 Vd NA 1.821 L/kg 1compartment NA NA Human Human -DTXSID4057845 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID4057845 TK.Half.Life NA 18.94 hours 1compartment NA NA Human Human -DTXSID4057845 Css NA 1.132 mg/L 3compartmentss NA 50% Human Human -DTXSID4057845 Css NA 4.794 mg/L 3compartmentss NA 95% Human Human -DTXSID4057845 Css NA 0.8478 mg/L PBTK NA 50% Human Human -DTXSID4057845 Css NA 3.267 mg/L PBTK NA 95% Human Human -DTXSID4057845 Clint NA 1.506 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057845 Fup NA 0.2594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057845 Vd NA 1.43 L/kg 1compartment NA NA Rat Human +DTXSID4057843 TK.Half.Life NA 0.6102 hours 1compartment NA NA Rat Human +DTXSID4057843 Css NA 0.01255 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057843 Css NA 0.06789 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057843 Css NA 0.008673 mg/L PBTK NA 50% Rat Human +DTXSID4057843 Css NA 0.04473 mg/L PBTK NA 95% Rat Human +DTXSID4057845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057845 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057845 Vd NA 1.201 L/kg 1compartment NA NA Human Human +DTXSID4057845 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4057845 TK.Half.Life NA 2.513 hours 1compartment NA NA Human Human +DTXSID4057845 Css NA 0.1838 mg/L 3compartmentss NA 50% Human Human +DTXSID4057845 Css NA 1.474 mg/L 3compartmentss NA 95% Human Human +DTXSID4057845 Css NA 0.1236 mg/L PBTK NA 50% Human Human +DTXSID4057845 Css NA 0.9357 mg/L PBTK NA 95% Human Human +DTXSID4057845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057845 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057845 Vd NA 0.9494 L/kg 1compartment NA NA Rat Human DTXSID4057845 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057845 TK.Half.Life NA 5.934 hours 1compartment NA NA Rat Human -DTXSID4057845 Css NA 0.4984 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057845 Css NA 1.602 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057845 Css NA 0.3592 mg/L PBTK NA 50% Rat Human -DTXSID4057845 Css NA 0.9877 mg/L PBTK NA 95% Rat Human -DTXSID4057847 Clint NA 2.457 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057847 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057847 Vd NA 0.2483 L/kg 1compartment NA NA Human Human +DTXSID4057845 TK.Half.Life NA 1.051 hours 1compartment NA NA Rat Human +DTXSID4057845 Css NA 0.02391 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057845 Css NA 0.1443 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057845 Css NA 0.01582 mg/L PBTK NA 50% Rat Human +DTXSID4057845 Css NA 0.09021 mg/L PBTK NA 95% Rat Human +DTXSID4057847 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057847 Fup 0.0684 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057847 Vd NA 0.3344 L/kg 1compartment NA NA Human Human DTXSID4057847 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID4057847 TK.Half.Life NA 9.369 hours 1compartment NA NA Human Human -DTXSID4057847 Css NA 6.994 mg/L 3compartmentss NA 50% Human Human -DTXSID4057847 Css NA 40.38 mg/L 3compartmentss NA 95% Human Human -DTXSID4057847 Css NA 4.209 mg/L PBTK NA 50% Human Human -DTXSID4057847 Css NA 23.42 mg/L PBTK NA 95% Human Human -DTXSID4057847 Clint NA 2.457 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057847 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057847 Vd NA 0.2434 L/kg 1compartment NA NA Rat Human +DTXSID4057847 TK.Half.Life NA 3.039 hours 1compartment NA NA Human Human +DTXSID4057847 Css NA 1.422 mg/L 3compartmentss NA 50% Human Human +DTXSID4057847 Css NA 9.951 mg/L 3compartmentss NA 95% Human Human +DTXSID4057847 Css NA 0.8818 mg/L PBTK NA 50% Human Human +DTXSID4057847 Css NA 5.873 mg/L PBTK NA 95% Human Human +DTXSID4057847 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057847 Fup 0.0684 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057847 Vd NA 0.328 L/kg 1compartment NA NA Rat Human DTXSID4057847 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID4057847 TK.Half.Life NA 5.291 hours 1compartment NA NA Rat Human -DTXSID4057847 Css NA 3.373 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057847 Css NA 14.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057847 Css NA 1.892 mg/L PBTK NA 50% Rat Human -DTXSID4057847 Css NA 7.843 mg/L PBTK NA 95% Rat Human -DTXSID4057849 Clint NA 3.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057849 Fup NA 0.0122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4057849 Vd NA 0.2969 L/kg 1compartment NA NA Human Human -DTXSID4057849 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID4057849 TK.Half.Life NA 22.08 hours 1compartment NA NA Human Human -DTXSID4057849 Css NA 13.58 mg/L 3compartmentss NA 50% Human Human -DTXSID4057849 Css NA 103 mg/L 3compartmentss NA 95% Human Human -DTXSID4057849 Css NA 8.12 mg/L PBTK NA 50% Human Human -DTXSID4057849 Css NA 60.06 mg/L PBTK NA 95% Human Human -DTXSID4057849 Clint NA 3.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057849 Fup NA 0.0122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4057849 Vd NA 0.2645 L/kg 1compartment NA NA Rat Human -DTXSID4057849 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID4057849 TK.Half.Life NA 11.94 hours 1compartment NA NA Rat Human -DTXSID4057849 Css NA 6.868 mg/L 3compartmentss NA 50% Rat Human -DTXSID4057849 Css NA 44.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID4057849 Css NA 3.835 mg/L PBTK NA 50% Rat Human -DTXSID4057849 Css NA 24.17 mg/L PBTK NA 95% Rat Human -DTXSID4058655 Clint NA 3.358 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4058655 Fup NA 0.0226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID4058655 Vd NA 1.651 L/kg 1compartment NA NA Human Human -DTXSID4058655 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID4058655 TK.Half.Life NA 77.22 hours 1compartment NA NA Human Human -DTXSID4058655 Css NA 7.682 mg/L 3compartmentss NA 50% Human Human -DTXSID4058655 Css NA 52.71 mg/L 3compartmentss NA 95% Human Human -DTXSID4058655 Css NA 4.849 mg/L PBTK NA 50% Human Human -DTXSID4058655 Css NA 31.91 mg/L PBTK NA 95% Human Human -DTXSID4058655 Clint NA 3.358 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4058655 Fup NA 0.0226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID4058655 Vd NA 1.224 L/kg 1compartment NA NA Rat Human -DTXSID4058655 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID4058655 TK.Half.Life NA 26.22 hours 1compartment NA NA Rat Human -DTXSID4058655 Css NA 3.973 mg/L 3compartmentss NA 50% Rat Human -DTXSID4058655 Css NA 21.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID4058655 Css NA 2.367 mg/L PBTK NA 50% Rat Human -DTXSID4058655 Css NA 11.89 mg/L PBTK NA 95% Rat Human -DTXSID40873078 Clint NA 4.568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID40873078 Fup NA 0.474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID40873078 Vd NA 2.854 L/kg 1compartment NA NA Human Human -DTXSID40873078 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID40873078 TK.Half.Life NA 5.479 hours 1compartment NA NA Human Human -DTXSID40873078 Css NA 0.1259 mg/L 3compartmentss NA 50% Human Human -DTXSID40873078 Css NA 1.015 mg/L 3compartmentss NA 95% Human Human -DTXSID40873078 Css NA 0.1406 mg/L PBTK NA 50% Human Human -DTXSID40873078 Css NA 0.8227 mg/L PBTK NA 95% Human Human -DTXSID40873078 Clint NA 4.568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID40873078 Fup NA 0.474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID40873078 Vd NA 2.894 L/kg 1compartment NA NA Rat Human -DTXSID40873078 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID40873078 TK.Half.Life NA 3.175 hours 1compartment NA NA Rat Human -DTXSID40873078 Css NA 0.05946 mg/L 3compartmentss NA 50% Rat Human -DTXSID40873078 Css NA 0.3968 mg/L 3compartmentss NA 95% Rat Human -DTXSID40873078 Css NA 0.06625 mg/L PBTK NA 50% Rat Human -DTXSID40873078 Css NA 0.2931 mg/L PBTK NA 95% Rat Human -DTXSID501018140 Clint NA 0.06807 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID501018140 Fup NA 0.2941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID501018140 Vd NA 0.5101 L/kg 1compartment NA NA Human Human +DTXSID4057847 TK.Half.Life NA 1.847 hours 1compartment NA NA Rat Human +DTXSID4057847 Css NA 0.1769 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057847 Css NA 0.8845 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057847 Css NA 0.1069 mg/L PBTK NA 50% Rat Human +DTXSID4057847 Css NA 0.5088 mg/L PBTK NA 95% Rat Human +DTXSID4057849 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057849 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057849 Vd NA 2.59 L/kg 1compartment NA NA Human Human +DTXSID4057849 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID4057849 TK.Half.Life NA 46.61 hours 1compartment NA NA Human Human +DTXSID4057849 Css NA 2.501 mg/L 3compartmentss NA 50% Human Human +DTXSID4057849 Css NA 18.44 mg/L 3compartmentss NA 95% Human Human +DTXSID4057849 Css NA 1.652 mg/L PBTK NA 50% Human Human +DTXSID4057849 Css NA 11.53 mg/L PBTK NA 95% Human Human +DTXSID4057849 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057849 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057849 Vd NA 1.93 L/kg 1compartment NA NA Rat Human +DTXSID4057849 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID4057849 TK.Half.Life NA 10.73 hours 1compartment NA NA Rat Human +DTXSID4057849 Css NA 0.3282 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057849 Css NA 2.044 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057849 Css NA 0.2135 mg/L PBTK NA 50% Rat Human +DTXSID4057849 Css NA 1.287 mg/L PBTK NA 95% Rat Human +DTXSID4057899 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4057899 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID4057899 Vd NA 0.6426 L/kg 1compartment NA NA Human Human +DTXSID4057899 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID4057899 TK.Half.Life NA 10.24 hours 1compartment NA NA Human Human +DTXSID4057899 Css NA 2.766 mg/L 3compartmentss NA 50% Human Human +DTXSID4057899 Css NA 27.5 mg/L 3compartmentss NA 95% Human Human +DTXSID4057899 Css NA 1.65 mg/L PBTK NA 50% Human Human +DTXSID4057899 Css NA 16.16 mg/L PBTK NA 95% Human Human +DTXSID4057899 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4057899 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID4057899 Vd NA 0.5018 L/kg 1compartment NA NA Rat Human +DTXSID4057899 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4057899 TK.Half.Life NA 5.142 hours 1compartment NA NA Rat Human +DTXSID4057899 Css NA 0.3646 mg/L 3compartmentss NA 50% Rat Human +DTXSID4057899 Css NA 3.013 mg/L 3compartmentss NA 95% Rat Human +DTXSID4057899 Css NA 0.2104 mg/L PBTK NA 50% Rat Human +DTXSID4057899 Css NA 1.698 mg/L PBTK NA 95% Rat Human +DTXSID4058655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4058655 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4058655 Vd NA 1.582 L/kg 1compartment NA NA Human Human +DTXSID4058655 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID4058655 TK.Half.Life NA 22.19 hours 1compartment NA NA Human Human +DTXSID4058655 Css NA 2.25 mg/L 3compartmentss NA 50% Human Human +DTXSID4058655 Css NA 19.36 mg/L 3compartmentss NA 95% Human Human +DTXSID4058655 Css NA 1.392 mg/L PBTK NA 50% Human Human +DTXSID4058655 Css NA 11.63 mg/L PBTK NA 95% Human Human +DTXSID4058655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4058655 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4058655 Vd NA 1.167 L/kg 1compartment NA NA Rat Human +DTXSID4058655 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID4058655 TK.Half.Life NA 8.305 hours 1compartment NA NA Rat Human +DTXSID4058655 Css NA 0.2932 mg/L 3compartmentss NA 50% Rat Human +DTXSID4058655 Css NA 2.17 mg/L 3compartmentss NA 95% Rat Human +DTXSID4058655 Css NA 0.1774 mg/L PBTK NA 50% Rat Human +DTXSID4058655 Css NA 1.28 mg/L PBTK NA 95% Rat Human +DTXSID4059702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4059702 Fup 0.0777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4059702 Vd NA 3.129 L/kg 1compartment NA NA Human Human +DTXSID4059702 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID4059702 TK.Half.Life NA 79.65 hours 1compartment NA NA Human Human +DTXSID4059702 Css NA 3.012 mg/L 3compartmentss NA 50% Human Human +DTXSID4059702 Css NA 19.19 mg/L 3compartmentss NA 95% Human Human +DTXSID4059702 Css NA 2.088 mg/L PBTK NA 50% Human Human +DTXSID4059702 Css NA 12.9 mg/L PBTK NA 95% Human Human +DTXSID4059702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4059702 Fup 0.0777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4059702 Vd NA 2.345 L/kg 1compartment NA NA Rat Human +DTXSID4059702 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID4059702 TK.Half.Life NA 10.67 hours 1compartment NA NA Rat Human +DTXSID4059702 Css NA 0.3868 mg/L 3compartmentss NA 50% Rat Human +DTXSID4059702 Css NA 2.143 mg/L 3compartmentss NA 95% Rat Human +DTXSID4059702 Css NA 0.2661 mg/L PBTK NA 50% Rat Human +DTXSID4059702 Css NA 1.415 mg/L PBTK NA 95% Rat Human +DTXSID4060442 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4060442 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4060442 Vd NA 0.6568 L/kg 1compartment NA NA Human Human +DTXSID4060442 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4060442 TK.Half.Life NA 7.005 hours 1compartment NA NA Human Human +DTXSID4060442 Css NA 1.051 mg/L 3compartmentss NA 50% Human Human +DTXSID4060442 Css NA 7.165 mg/L 3compartmentss NA 95% Human Human +DTXSID4060442 Css NA 0.835 mg/L PBTK NA 50% Human Human +DTXSID4060442 Css NA 4.503 mg/L PBTK NA 95% Human Human +DTXSID4060442 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4060442 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4060442 Vd NA 0.6717 L/kg 1compartment NA NA Rat Human +DTXSID4060442 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4060442 TK.Half.Life NA 2.437 hours 1compartment NA NA Rat Human +DTXSID4060442 Css NA 0.02028 mg/L 3compartmentss NA 50% Rat Human +DTXSID4060442 Css NA 0.1698 mg/L 3compartmentss NA 95% Rat Human +DTXSID4060442 Css NA 0.01554 mg/L PBTK NA 50% Rat Human +DTXSID4060442 Css NA 0.1063 mg/L PBTK NA 95% Rat Human +DTXSID4061098 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4061098 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4061098 Vd NA 6.882 L/kg 1compartment NA NA Human Human +DTXSID4061098 Days.Css NA 40 Days PBTK NA NA Human Human +DTXSID4061098 TK.Half.Life NA 205.8 hours 1compartment NA NA Human Human +DTXSID4061098 Css NA 1.393 mg/L 3compartmentss NA 50% Human Human +DTXSID4061098 Css NA 8.668 mg/L 3compartmentss NA 95% Human Human +DTXSID4061098 Css NA 1.319 mg/L PBTK NA 50% Human Human +DTXSID4061098 Css NA 8.042 mg/L PBTK NA 95% Human Human +DTXSID4061098 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4061098 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4061098 Vd NA 5.328 L/kg 1compartment NA NA Rat Human +DTXSID4061098 Days.Css NA 23 Days PBTK NA NA Rat Human +DTXSID4061098 TK.Half.Life NA 27.94 hours 1compartment NA NA Rat Human +DTXSID4061098 Css NA 0.01452 mg/L 3compartmentss NA 50% Rat Human +DTXSID4061098 Css NA 0.09072 mg/L 3compartmentss NA 95% Rat Human +DTXSID4061098 Css NA 0.01349 mg/L PBTK NA 50% Rat Human +DTXSID4061098 Css NA 0.08341 mg/L PBTK NA 95% Rat Human +DTXSID4063030 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4063030 Fup 0.0094 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4063030 Vd NA 2.813 L/kg 1compartment NA NA Human Human +DTXSID4063030 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID4063030 TK.Half.Life NA 59.5 hours 1compartment NA NA Human Human +DTXSID4063030 Css NA 2.793 mg/L 3compartmentss NA 50% Human Human +DTXSID4063030 Css NA 19.97 mg/L 3compartmentss NA 95% Human Human +DTXSID4063030 Css NA 1.886 mg/L PBTK NA 50% Human Human +DTXSID4063030 Css NA 12.71 mg/L PBTK NA 95% Human Human +DTXSID4063030 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4063030 Fup 0.0094 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4063030 Vd NA 2.102 L/kg 1compartment NA NA Rat Human +DTXSID4063030 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID4063030 TK.Half.Life NA 11.39 hours 1compartment NA NA Rat Human +DTXSID4063030 Css NA 0.363 mg/L 3compartmentss NA 50% Rat Human +DTXSID4063030 Css NA 2.239 mg/L 3compartmentss NA 95% Rat Human +DTXSID4063030 Css NA 0.2411 mg/L PBTK NA 50% Rat Human +DTXSID4063030 Css NA 1.438 mg/L PBTK NA 95% Rat Human +DTXSID40634520 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40634520 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40634520 Vd NA 1.137 L/kg 1compartment NA NA Human Human +DTXSID40634520 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40634520 TK.Half.Life NA 1.909 hours 1compartment NA NA Human Human +DTXSID40634520 Css NA 0.1144 mg/L 3compartmentss NA 50% Human Human +DTXSID40634520 Css NA 0.8956 mg/L 3compartmentss NA 95% Human Human +DTXSID40634520 Css NA 0.09498 mg/L PBTK NA 50% Human Human +DTXSID40634520 Css NA 0.6206 mg/L PBTK NA 95% Human Human +DTXSID40634520 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40634520 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40634520 Vd NA 1.126 L/kg 1compartment NA NA Rat Human +DTXSID40634520 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40634520 TK.Half.Life NA 1.041 hours 1compartment NA NA Rat Human +DTXSID40634520 Css NA 0.008346 mg/L 3compartmentss NA 50% Rat Human +DTXSID40634520 Css NA 0.06186 mg/L 3compartmentss NA 95% Rat Human +DTXSID40634520 Css NA 0.007212 mg/L PBTK NA 50% Rat Human +DTXSID40634520 Css NA 0.04142 mg/L PBTK NA 95% Rat Human +DTXSID40658943 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40658943 Fup 0.0466 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40658943 Vd NA 1.222 L/kg 1compartment NA NA Human Human +DTXSID40658943 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40658943 TK.Half.Life NA 16.45 hours 1compartment NA NA Human Human +DTXSID40658943 Css NA 1.888 mg/L 3compartmentss NA 50% Human Human +DTXSID40658943 Css NA 12.92 mg/L 3compartmentss NA 95% Human Human +DTXSID40658943 Css NA 1.191 mg/L PBTK NA 50% Human Human +DTXSID40658943 Css NA 7.73 mg/L PBTK NA 95% Human Human +DTXSID40658943 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40658943 Fup 0.0466 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40658943 Vd NA 0.9224 L/kg 1compartment NA NA Rat Human +DTXSID40658943 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40658943 TK.Half.Life NA 6.71 hours 1compartment NA NA Rat Human +DTXSID40658943 Css NA 0.09632 mg/L 3compartmentss NA 50% Rat Human +DTXSID40658943 Css NA 0.6878 mg/L 3compartmentss NA 95% Rat Human +DTXSID40658943 Css NA 0.05856 mg/L PBTK NA 50% Rat Human +DTXSID40658943 Css NA 0.4007 mg/L PBTK NA 95% Rat Human +DTXSID40678540 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40678540 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40678540 Vd NA 1.341 L/kg 1compartment NA NA Human Human +DTXSID40678540 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40678540 TK.Half.Life NA 12.28 hours 1compartment NA NA Human Human +DTXSID40678540 Css NA 1.17 mg/L 3compartmentss NA 50% Human Human +DTXSID40678540 Css NA 6.766 mg/L 3compartmentss NA 95% Human Human +DTXSID40678540 Css NA 0.7972 mg/L PBTK NA 50% Human Human +DTXSID40678540 Css NA 4.247 mg/L PBTK NA 95% Human Human +DTXSID40678540 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40678540 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40678540 Vd NA 1.049 L/kg 1compartment NA NA Rat Human +DTXSID40678540 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40678540 TK.Half.Life NA 4.767 hours 1compartment NA NA Rat Human +DTXSID40678540 Css NA 0.1342 mg/L 3compartmentss NA 50% Rat Human +DTXSID40678540 Css NA 0.5802 mg/L 3compartmentss NA 95% Rat Human +DTXSID40678540 Css NA 0.0895 mg/L PBTK NA 50% Rat Human +DTXSID40678540 Css NA 0.351 mg/L PBTK NA 95% Rat Human +DTXSID40678984 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40678984 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40678984 Vd NA 2.817 L/kg 1compartment NA NA Human Human +DTXSID40678984 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40678984 TK.Half.Life NA 17.54 hours 1compartment NA NA Human Human +DTXSID40678984 Css NA 0.6458 mg/L 3compartmentss NA 50% Human Human +DTXSID40678984 Css NA 4.51 mg/L 3compartmentss NA 95% Human Human +DTXSID40678984 Css NA 0.4514 mg/L PBTK NA 50% Human Human +DTXSID40678984 Css NA 3.016 mg/L PBTK NA 95% Human Human +DTXSID40678984 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40678984 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40678984 Vd NA 2.119 L/kg 1compartment NA NA Rat Human +DTXSID40678984 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40678984 TK.Half.Life NA 3.644 hours 1compartment NA NA Rat Human +DTXSID40678984 Css NA 0.04759 mg/L 3compartmentss NA 50% Rat Human +DTXSID40678984 Css NA 0.2699 mg/L 3compartmentss NA 95% Rat Human +DTXSID40678984 Css NA 0.03282 mg/L PBTK NA 50% Rat Human +DTXSID40678984 Css NA 0.1737 mg/L PBTK NA 95% Rat Human +DTXSID4073259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4073259 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4073259 Vd NA 0.9824 L/kg 1compartment NA NA Human Human +DTXSID4073259 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4073259 TK.Half.Life NA 1.144 hours 1compartment NA NA Human Human +DTXSID4073259 Css NA 0.05396 mg/L 3compartmentss NA 50% Human Human +DTXSID4073259 Css NA 0.4156 mg/L 3compartmentss NA 95% Human Human +DTXSID4073259 Css NA 0.04113 mg/L PBTK NA 50% Human Human +DTXSID4073259 Css NA 0.2896 mg/L PBTK NA 95% Human Human +DTXSID4073259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4073259 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4073259 Vd NA 0.8664 L/kg 1compartment NA NA Rat Human +DTXSID4073259 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4073259 TK.Half.Life NA 0.5161 hours 1compartment NA NA Rat Human +DTXSID4073259 Css NA 0.006698 mg/L 3compartmentss NA 50% Rat Human +DTXSID4073259 Css NA 0.04077 mg/L 3compartmentss NA 95% Rat Human +DTXSID4073259 Css NA 0.0051 mg/L PBTK NA 50% Rat Human +DTXSID4073259 Css NA 0.02758 mg/L PBTK NA 95% Rat Human +DTXSID4075328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4075328 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID4075328 Vd NA 2.486 L/kg 1compartment NA NA Human Human +DTXSID4075328 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID4075328 TK.Half.Life NA 4.409 hours 1compartment NA NA Human Human +DTXSID4075328 Css NA 0.1203 mg/L 3compartmentss NA 50% Human Human +DTXSID4075328 Css NA 0.7985 mg/L 3compartmentss NA 95% Human Human +DTXSID4075328 Css NA 0.09229 mg/L PBTK NA 50% Human Human +DTXSID4075328 Css NA 0.579 mg/L PBTK NA 95% Human Human +DTXSID4075328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4075328 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID4075328 Vd NA 1.922 L/kg 1compartment NA NA Rat Human +DTXSID4075328 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID4075328 TK.Half.Life NA 1.301 hours 1compartment NA NA Rat Human +DTXSID4075328 Css NA 0.01495 mg/L 3compartmentss NA 50% Rat Human +DTXSID4075328 Css NA 0.07978 mg/L 3compartmentss NA 95% Rat Human +DTXSID4075328 Css NA 0.01143 mg/L PBTK NA 50% Rat Human +DTXSID4075328 Css NA 0.05705 mg/L PBTK NA 95% Rat Human +DTXSID40861036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40861036 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40861036 Vd NA 2.064 L/kg 1compartment NA NA Human Human +DTXSID40861036 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40861036 TK.Half.Life NA 19.04 hours 1compartment NA NA Human Human +DTXSID40861036 Css NA 1.344 mg/L 3compartmentss NA 50% Human Human +DTXSID40861036 Css NA 10.7 mg/L 3compartmentss NA 95% Human Human +DTXSID40861036 Css NA 0.8725 mg/L PBTK NA 50% Human Human +DTXSID40861036 Css NA 6.694 mg/L PBTK NA 95% Human Human +DTXSID40861036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40861036 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40861036 Vd NA 1.536 L/kg 1compartment NA NA Rat Human +DTXSID40861036 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40861036 TK.Half.Life NA 5.97 hours 1compartment NA NA Rat Human +DTXSID40861036 Css NA 0.1718 mg/L 3compartmentss NA 50% Rat Human +DTXSID40861036 Css NA 1.153 mg/L 3compartmentss NA 95% Rat Human +DTXSID40861036 Css NA 0.1088 mg/L PBTK NA 50% Rat Human +DTXSID40861036 Css NA 0.6906 mg/L PBTK NA 95% Rat Human +DTXSID40861672 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40861672 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40861672 Vd NA 0.3128 L/kg 1compartment NA NA Human Human +DTXSID40861672 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40861672 TK.Half.Life NA 0.5767 hours 1compartment NA NA Human Human +DTXSID40861672 Css NA 0.05371 mg/L 3compartmentss NA 50% Human Human +DTXSID40861672 Css NA 0.4244 mg/L 3compartmentss NA 95% Human Human +DTXSID40861672 Css NA 0.03562 mg/L PBTK NA 50% Human Human +DTXSID40861672 Css NA 0.2672 mg/L PBTK NA 95% Human Human +DTXSID40861672 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40861672 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40861672 Vd NA 0.3283 L/kg 1compartment NA NA Rat Human +DTXSID40861672 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40861672 TK.Half.Life NA 0.3336 hours 1compartment NA NA Rat Human +DTXSID40861672 Css NA 0.0004238 mg/L 3compartmentss NA 50% Rat Human +DTXSID40861672 Css NA 0.002903 mg/L 3compartmentss NA 95% Rat Human +DTXSID40861672 Css NA 0.0002694 mg/L PBTK NA 50% Rat Human +DTXSID40861672 Css NA 0.001705 mg/L PBTK NA 95% Rat Human +DTXSID40862245 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40862245 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40862245 Vd NA 2.4 L/kg 1compartment NA NA Human Human +DTXSID40862245 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40862245 TK.Half.Life NA 5.532 hours 1compartment NA NA Human Human +DTXSID40862245 Css NA 0.1819 mg/L 3compartmentss NA 50% Human Human +DTXSID40862245 Css NA 1.207 mg/L 3compartmentss NA 95% Human Human +DTXSID40862245 Css NA 0.1335 mg/L PBTK NA 50% Human Human +DTXSID40862245 Css NA 0.8297 mg/L PBTK NA 95% Human Human +DTXSID40862245 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40862245 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40862245 Vd NA 1.837 L/kg 1compartment NA NA Rat Human +DTXSID40862245 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40862245 TK.Half.Life NA 1.626 hours 1compartment NA NA Rat Human +DTXSID40862245 Css NA 0.02291 mg/L 3compartmentss NA 50% Rat Human +DTXSID40862245 Css NA 0.1182 mg/L 3compartmentss NA 95% Rat Human +DTXSID40862245 Css NA 0.01672 mg/L PBTK NA 50% Rat Human +DTXSID40862245 Css NA 0.08032 mg/L PBTK NA 95% Rat Human +DTXSID40862442 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40862442 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40862442 Vd NA 2.464 L/kg 1compartment NA NA Human Human +DTXSID40862442 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40862442 TK.Half.Life NA 9.272 hours 1compartment NA NA Human Human +DTXSID40862442 Css NA 0.3956 mg/L 3compartmentss NA 50% Human Human +DTXSID40862442 Css NA 2.645 mg/L 3compartmentss NA 95% Human Human +DTXSID40862442 Css NA 0.2754 mg/L PBTK NA 50% Human Human +DTXSID40862442 Css NA 1.753 mg/L PBTK NA 95% Human Human +DTXSID40862442 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40862442 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40862442 Vd NA 1.863 L/kg 1compartment NA NA Rat Human +DTXSID40862442 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40862442 TK.Half.Life NA 2.521 hours 1compartment NA NA Rat Human +DTXSID40862442 Css NA 0.05134 mg/L 3compartmentss NA 50% Rat Human +DTXSID40862442 Css NA 0.2728 mg/L 3compartmentss NA 95% Rat Human +DTXSID40862442 Css NA 0.03513 mg/L PBTK NA 50% Rat Human +DTXSID40862442 Css NA 0.1791 mg/L PBTK NA 95% Rat Human +DTXSID40863297 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40863297 Fup 0.728 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40863297 Vd NA 0.9364 L/kg 1compartment NA NA Human Human +DTXSID40863297 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40863297 TK.Half.Life NA 0.7524 hours 1compartment NA NA Human Human +DTXSID40863297 Css NA 0.02157 mg/L 3compartmentss NA 50% Human Human +DTXSID40863297 Css NA 0.251 mg/L 3compartmentss NA 95% Human Human +DTXSID40863297 Css NA 0.01813 mg/L PBTK NA 50% Human Human +DTXSID40863297 Css NA 0.1827 mg/L PBTK NA 95% Human Human +DTXSID40863297 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40863297 Fup 0.728 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40863297 Vd NA 0.9126 L/kg 1compartment NA NA Rat Human +DTXSID40863297 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40863297 TK.Half.Life NA 0.3578 hours 1compartment NA NA Rat Human +DTXSID40863297 Css NA 0.000778 mg/L 3compartmentss NA 50% Rat Human +DTXSID40863297 Css NA 0.01091 mg/L 3compartmentss NA 95% Rat Human +DTXSID40863297 Css NA 0.0006468 mg/L PBTK NA 50% Rat Human +DTXSID40863297 Css NA 0.007265 mg/L PBTK NA 95% Rat Human +DTXSID40863959 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40863959 Fup 0.702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40863959 Vd NA 0.9159 L/kg 1compartment NA NA Human Human +DTXSID40863959 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40863959 TK.Half.Life NA 0.7514 hours 1compartment NA NA Human Human +DTXSID40863959 Css NA 0.022 mg/L 3compartmentss NA 50% Human Human +DTXSID40863959 Css NA 0.286 mg/L 3compartmentss NA 95% Human Human +DTXSID40863959 Css NA 0.01845 mg/L PBTK NA 50% Human Human +DTXSID40863959 Css NA 0.1965 mg/L PBTK NA 95% Human Human +DTXSID40863959 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40863959 Fup 0.702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40863959 Vd NA 0.8922 L/kg 1compartment NA NA Rat Human +DTXSID40863959 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40863959 TK.Half.Life NA 0.3582 hours 1compartment NA NA Rat Human +DTXSID40863959 Css NA 0.0007984 mg/L 3compartmentss NA 50% Rat Human +DTXSID40863959 Css NA 0.01086 mg/L 3compartmentss NA 95% Rat Human +DTXSID40863959 Css NA 0.0006616 mg/L PBTK NA 50% Rat Human +DTXSID40863959 Css NA 0.007472 mg/L PBTK NA 95% Rat Human +DTXSID40865110 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40865110 Fup 0.51 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40865110 Vd NA 3.887 L/kg 1compartment NA NA Human Human +DTXSID40865110 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40865110 TK.Half.Life NA 5.94 hours 1compartment NA NA Human Human +DTXSID40865110 Css NA 0.0827 mg/L 3compartmentss NA 50% Human Human +DTXSID40865110 Css NA 0.7779 mg/L 3compartmentss NA 95% Human Human +DTXSID40865110 Css NA 0.1035 mg/L PBTK NA 50% Human Human +DTXSID40865110 Css NA 0.6764 mg/L PBTK NA 95% Human Human +DTXSID40865110 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40865110 Fup 0.51 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40865110 Vd NA 3.868 L/kg 1compartment NA NA Rat Human +DTXSID40865110 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40865110 TK.Half.Life NA 3.146 hours 1compartment NA NA Rat Human +DTXSID40865110 Css NA 0.009458 mg/L 3compartmentss NA 50% Rat Human +DTXSID40865110 Css NA 0.06868 mg/L 3compartmentss NA 95% Rat Human +DTXSID40865110 Css NA 0.01216 mg/L PBTK NA 50% Rat Human +DTXSID40865110 Css NA 0.05721 mg/L PBTK NA 95% Rat Human +DTXSID40865478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40865478 Fup 0.49 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40865478 Vd NA 1.155 L/kg 1compartment NA NA Human Human +DTXSID40865478 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40865478 TK.Half.Life NA 1.15 hours 1compartment NA NA Human Human +DTXSID40865478 Css NA 0.03862 mg/L 3compartmentss NA 50% Human Human +DTXSID40865478 Css NA 0.3538 mg/L 3compartmentss NA 95% Human Human +DTXSID40865478 Css NA 0.0316 mg/L PBTK NA 50% Human Human +DTXSID40865478 Css NA 0.2447 mg/L PBTK NA 95% Human Human +DTXSID40865478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40865478 Fup 0.49 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40865478 Vd NA 1.021 L/kg 1compartment NA NA Rat Human +DTXSID40865478 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40865478 TK.Half.Life NA 0.5045 hours 1compartment NA NA Rat Human +DTXSID40865478 Css NA 0.004884 mg/L 3compartmentss NA 50% Rat Human +DTXSID40865478 Css NA 0.03481 mg/L 3compartmentss NA 95% Rat Human +DTXSID40865478 Css NA 0.004006 mg/L PBTK NA 50% Rat Human +DTXSID40865478 Css NA 0.02372 mg/L PBTK NA 95% Rat Human +DTXSID40868303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40868303 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40868303 Vd NA 2.962 L/kg 1compartment NA NA Human Human +DTXSID40868303 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40868303 TK.Half.Life NA 11.91 hours 1compartment NA NA Human Human +DTXSID40868303 Css NA 0.3842 mg/L 3compartmentss NA 50% Human Human +DTXSID40868303 Css NA 2.389 mg/L 3compartmentss NA 95% Human Human +DTXSID40868303 Css NA 0.2794 mg/L PBTK NA 50% Human Human +DTXSID40868303 Css NA 1.667 mg/L PBTK NA 95% Human Human +DTXSID40868303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40868303 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40868303 Vd NA 2.242 L/kg 1compartment NA NA Rat Human +DTXSID40868303 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40868303 TK.Half.Life NA 2.357 hours 1compartment NA NA Rat Human +DTXSID40868303 Css NA 0.04818 mg/L 3compartmentss NA 50% Rat Human +DTXSID40868303 Css NA 0.2404 mg/L 3compartmentss NA 95% Rat Human +DTXSID40868303 Css NA 0.03478 mg/L PBTK NA 50% Rat Human +DTXSID40868303 Css NA 0.1685 mg/L PBTK NA 95% Rat Human +DTXSID40868904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40868904 Fup 0.32 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40868904 Vd NA 0.7217 L/kg 1compartment NA NA Human Human +DTXSID40868904 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40868904 TK.Half.Life NA 0.8572 hours 1compartment NA NA Human Human +DTXSID40868904 Css NA 0.02509 mg/L 3compartmentss NA 50% Human Human +DTXSID40868904 Css NA 0.2587 mg/L 3compartmentss NA 95% Human Human +DTXSID40868904 Css NA 0.02 mg/L PBTK NA 50% Human Human +DTXSID40868904 Css NA 0.1813 mg/L PBTK NA 95% Human Human +DTXSID40868904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40868904 Fup 0.32 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40868904 Vd NA 0.7179 L/kg 1compartment NA NA Rat Human +DTXSID40868904 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40868904 TK.Half.Life NA 0.4572 hours 1compartment NA NA Rat Human +DTXSID40868904 Css NA 0.0002272 mg/L 3compartmentss NA 50% Rat Human +DTXSID40868904 Css NA 0.002176 mg/L 3compartmentss NA 95% Rat Human +DTXSID40868904 Css NA 0.0001779 mg/L PBTK NA 50% Rat Human +DTXSID40868904 Css NA 0.001505 mg/L PBTK NA 95% Rat Human +DTXSID40869032 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40869032 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40869032 Vd NA 0.47 L/kg 1compartment NA NA Human Human +DTXSID40869032 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40869032 TK.Half.Life NA 3.041 hours 1compartment NA NA Human Human +DTXSID40869032 Css NA 0.5144 mg/L 3compartmentss NA 50% Human Human +DTXSID40869032 Css NA 3.146 mg/L 3compartmentss NA 95% Human Human +DTXSID40869032 Css NA 0.3817 mg/L PBTK NA 50% Human Human +DTXSID40869032 Css NA 1.998 mg/L PBTK NA 95% Human Human +DTXSID40869032 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40869032 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40869032 Vd NA 0.5028 L/kg 1compartment NA NA Rat Human +DTXSID40869032 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40869032 TK.Half.Life NA 1.109 hours 1compartment NA NA Rat Human +DTXSID40869032 Css NA 0.002602 mg/L 3compartmentss NA 50% Rat Human +DTXSID40869032 Css NA 0.01791 mg/L 3compartmentss NA 95% Rat Human +DTXSID40869032 Css NA 0.001866 mg/L PBTK NA 50% Rat Human +DTXSID40869032 Css NA 0.01062 mg/L PBTK NA 95% Rat Human +DTXSID40869118 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40869118 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40869118 Vd NA 1.99 L/kg 1compartment NA NA Human Human +DTXSID40869118 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID40869118 TK.Half.Life NA 18.4 hours 1compartment NA NA Human Human +DTXSID40869118 Css NA 0.825 mg/L 3compartmentss NA 50% Human Human +DTXSID40869118 Css NA 6.541 mg/L 3compartmentss NA 95% Human Human +DTXSID40869118 Css NA 0.8558 mg/L PBTK NA 50% Human Human +DTXSID40869118 Css NA 4.508 mg/L PBTK NA 95% Human Human +DTXSID40869118 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40869118 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40869118 Vd NA 1.997 L/kg 1compartment NA NA Rat Human +DTXSID40869118 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40869118 TK.Half.Life NA 6.29 hours 1compartment NA NA Rat Human +DTXSID40869118 Css NA 0.04866 mg/L 3compartmentss NA 50% Rat Human +DTXSID40869118 Css NA 0.3889 mg/L 3compartmentss NA 95% Rat Human +DTXSID40869118 Css NA 0.05115 mg/L PBTK NA 50% Rat Human +DTXSID40869118 Css NA 0.2554 mg/L PBTK NA 95% Rat Human +DTXSID40869931 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40869931 Fup 0.0303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40869931 Vd NA 1.903 L/kg 1compartment NA NA Human Human +DTXSID40869931 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40869931 TK.Half.Life NA 14.24 hours 1compartment NA NA Human Human +DTXSID40869931 Css NA 1.073 mg/L 3compartmentss NA 50% Human Human +DTXSID40869931 Css NA 8.809 mg/L 3compartmentss NA 95% Human Human +DTXSID40869931 Css NA 0.6948 mg/L PBTK NA 50% Human Human +DTXSID40869931 Css NA 5.429 mg/L PBTK NA 95% Human Human +DTXSID40869931 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40869931 Fup 0.0303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40869931 Vd NA 1.417 L/kg 1compartment NA NA Rat Human +DTXSID40869931 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40869931 TK.Half.Life NA 4.78 hours 1compartment NA NA Rat Human +DTXSID40869931 Css NA 0.1374 mg/L 3compartmentss NA 50% Rat Human +DTXSID40869931 Css NA 0.928 mg/L 3compartmentss NA 95% Rat Human +DTXSID40869931 Css NA 0.08643 mg/L PBTK NA 50% Rat Human +DTXSID40869931 Css NA 0.5528 mg/L PBTK NA 95% Rat Human +DTXSID40869971 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40869971 Fup 0.0699 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40869971 Vd NA 2.785 L/kg 1compartment NA NA Human Human +DTXSID40869971 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID40869971 TK.Half.Life NA 66.46 hours 1compartment NA NA Human Human +DTXSID40869971 Css NA 2.661 mg/L 3compartmentss NA 50% Human Human +DTXSID40869971 Css NA 15.77 mg/L 3compartmentss NA 95% Human Human +DTXSID40869971 Css NA 1.822 mg/L PBTK NA 50% Human Human +DTXSID40869971 Css NA 10.51 mg/L PBTK NA 95% Human Human +DTXSID40869971 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40869971 Fup 0.0699 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40869971 Vd NA 2.091 L/kg 1compartment NA NA Rat Human +DTXSID40869971 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID40869971 TK.Half.Life NA 12.8 hours 1compartment NA NA Rat Human +DTXSID40869971 Css NA 0.1277 mg/L 3compartmentss NA 50% Rat Human +DTXSID40869971 Css NA 0.7883 mg/L 3compartmentss NA 95% Rat Human +DTXSID40869971 Css NA 0.08608 mg/L PBTK NA 50% Rat Human +DTXSID40869971 Css NA 0.5035 mg/L PBTK NA 95% Rat Human +DTXSID40870229 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40870229 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40870229 Vd NA 0.9683 L/kg 1compartment NA NA Human Human +DTXSID40870229 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40870229 TK.Half.Life NA 10.5 hours 1compartment NA NA Human Human +DTXSID40870229 Css NA 0.6344 mg/L 3compartmentss NA 50% Human Human +DTXSID40870229 Css NA 4.553 mg/L 3compartmentss NA 95% Human Human +DTXSID40870229 Css NA 0.5362 mg/L PBTK NA 50% Human Human +DTXSID40870229 Css NA 2.924 mg/L PBTK NA 95% Human Human +DTXSID40870229 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40870229 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40870229 Vd NA 0.9075 L/kg 1compartment NA NA Rat Human +DTXSID40870229 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40870229 TK.Half.Life NA 3.256 hours 1compartment NA NA Rat Human +DTXSID40870229 Css NA 0.003326 mg/L 3compartmentss NA 50% Rat Human +DTXSID40870229 Css NA 0.02584 mg/L 3compartmentss NA 95% Rat Human +DTXSID40870229 Css NA 0.002706 mg/L PBTK NA 50% Rat Human +DTXSID40870229 Css NA 0.01569 mg/L PBTK NA 95% Rat Human +DTXSID40873215 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40873215 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40873215 Vd NA 0.8739 L/kg 1compartment NA NA Human Human +DTXSID40873215 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40873215 TK.Half.Life NA 3.215 hours 1compartment NA NA Human Human +DTXSID40873215 Css NA 0.4772 mg/L 3compartmentss NA 50% Human Human +DTXSID40873215 Css NA 3.839 mg/L 3compartmentss NA 95% Human Human +DTXSID40873215 Css NA 0.3042 mg/L PBTK NA 50% Human Human +DTXSID40873215 Css NA 2.325 mg/L PBTK NA 95% Human Human +DTXSID40873215 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40873215 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40873215 Vd NA 0.7649 L/kg 1compartment NA NA Rat Human +DTXSID40873215 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40873215 TK.Half.Life NA 1.697 hours 1compartment NA NA Rat Human +DTXSID40873215 Css NA 0.06162 mg/L 3compartmentss NA 50% Rat Human +DTXSID40873215 Css NA 0.3965 mg/L 3compartmentss NA 95% Rat Human +DTXSID40873215 Css NA 0.03819 mg/L PBTK NA 50% Rat Human +DTXSID40873215 Css NA 0.2357 mg/L PBTK NA 95% Rat Human +DTXSID40874368 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40874368 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40874368 Vd NA 2.092 L/kg 1compartment NA NA Human Human +DTXSID40874368 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID40874368 TK.Half.Life NA 64.96 hours 1compartment NA NA Human Human +DTXSID40874368 Css NA 3.169 mg/L 3compartmentss NA 50% Human Human +DTXSID40874368 Css NA 11.39 mg/L 3compartmentss NA 95% Human Human +DTXSID40874368 Css NA 2.491 mg/L PBTK NA 50% Human Human +DTXSID40874368 Css NA 7.706 mg/L PBTK NA 95% Human Human +DTXSID40874368 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40874368 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40874368 Vd NA 1.658 L/kg 1compartment NA NA Rat Human +DTXSID40874368 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID40874368 TK.Half.Life NA 11.9 hours 1compartment NA NA Rat Human +DTXSID40874368 Css NA 0.1986 mg/L 3compartmentss NA 50% Rat Human +DTXSID40874368 Css NA 0.5919 mg/L 3compartmentss NA 95% Rat Human +DTXSID40874368 Css NA 0.1565 mg/L PBTK NA 50% Rat Human +DTXSID40874368 Css NA 0.3863 mg/L PBTK NA 95% Rat Human +DTXSID40880060 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880060 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880060 Vd NA 1.199 L/kg 1compartment NA NA Human Human +DTXSID40880060 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40880060 TK.Half.Life NA 4.857 hours 1compartment NA NA Human Human +DTXSID40880060 Css NA 0.4152 mg/L 3compartmentss NA 50% Human Human +DTXSID40880060 Css NA 2.368 mg/L 3compartmentss NA 95% Human Human +DTXSID40880060 Css NA 0.2898 mg/L PBTK NA 50% Human Human +DTXSID40880060 Css NA 1.579 mg/L PBTK NA 95% Human Human +DTXSID40880060 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880060 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880060 Vd NA 0.9628 L/kg 1compartment NA NA Rat Human +DTXSID40880060 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40880060 TK.Half.Life NA 2.091 hours 1compartment NA NA Rat Human +DTXSID40880060 Css NA 0.04938 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880060 Css NA 0.2078 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880060 Css NA 0.03432 mg/L PBTK NA 50% Rat Human +DTXSID40880060 Css NA 0.1313 mg/L PBTK NA 95% Rat Human +DTXSID40880686 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880686 Fup 0.0121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880686 Vd NA 3.311 L/kg 1compartment NA NA Human Human +DTXSID40880686 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID40880686 TK.Half.Life NA 100.3 hours 1compartment NA NA Human Human +DTXSID40880686 Css NA 3.376 mg/L 3compartmentss NA 50% Human Human +DTXSID40880686 Css NA 20.18 mg/L 3compartmentss NA 95% Human Human +DTXSID40880686 Css NA 2.386 mg/L PBTK NA 50% Human Human +DTXSID40880686 Css NA 14.23 mg/L PBTK NA 95% Human Human +DTXSID40880686 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880686 Fup 0.0121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880686 Vd NA 2.485 L/kg 1compartment NA NA Rat Human +DTXSID40880686 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID40880686 TK.Half.Life NA 13.56 hours 1compartment NA NA Rat Human +DTXSID40880686 Css NA 0.4414 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880686 Css NA 2.159 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880686 Css NA 0.3081 mg/L PBTK NA 50% Rat Human +DTXSID40880686 Css NA 1.515 mg/L PBTK NA 95% Rat Human +DTXSID40880707 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880707 Fup 0.091 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880707 Vd NA 3.047 L/kg 1compartment NA NA Human Human +DTXSID40880707 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID40880707 TK.Half.Life NA 37.9 hours 1compartment NA NA Human Human +DTXSID40880707 Css NA 1.413 mg/L 3compartmentss NA 50% Human Human +DTXSID40880707 Css NA 9.336 mg/L 3compartmentss NA 95% Human Human +DTXSID40880707 Css NA 0.9878 mg/L PBTK NA 50% Human Human +DTXSID40880707 Css NA 6.3 mg/L PBTK NA 95% Human Human +DTXSID40880707 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880707 Fup 0.091 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880707 Vd NA 2.287 L/kg 1compartment NA NA Rat Human +DTXSID40880707 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID40880707 TK.Half.Life NA 5.919 hours 1compartment NA NA Rat Human +DTXSID40880707 Css NA 0.1856 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880707 Css NA 1.038 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880707 Css NA 0.1283 mg/L PBTK NA 50% Rat Human +DTXSID40880707 Css NA 0.6949 mg/L PBTK NA 95% Rat Human +DTXSID40880722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880722 Fup 0.03 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880722 Vd NA 46.22 L/kg 1compartment NA NA Human Human +DTXSID40880722 Days.Css NA 338 Days PBTK NA NA Human Human +DTXSID40880722 TK.Half.Life NA 1358 hours 1compartment NA NA Human Human +DTXSID40880722 Css NA 0.2538 mg/L 3compartmentss NA 50% Human Human +DTXSID40880722 Css NA 1.769 mg/L 3compartmentss NA 95% Human Human +DTXSID40880722 Css NA 1.296 mg/L PBTK NA 50% Human Human +DTXSID40880722 Css NA 8.358 mg/L PBTK NA 95% Human Human +DTXSID40880722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880722 Fup 0.03 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880722 Vd NA 38.85 L/kg 1compartment NA NA Rat Human +DTXSID40880722 Days.Css NA 212 Days PBTK NA NA Rat Human +DTXSID40880722 TK.Half.Life NA 194.7 hours 1compartment NA NA Rat Human +DTXSID40880722 Css NA 0.002508 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880722 Css NA 0.01527 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880722 Css NA 0.01366 mg/L PBTK NA 50% Rat Human +DTXSID40880722 Css NA 0.0824 mg/L PBTK NA 95% Rat Human +DTXSID40880762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880762 Fup 0.821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880762 Vd NA 1.083 L/kg 1compartment NA NA Human Human +DTXSID40880762 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40880762 TK.Half.Life NA 0.8087 hours 1compartment NA NA Human Human +DTXSID40880762 Css NA 0.01931 mg/L 3compartmentss NA 50% Human Human +DTXSID40880762 Css NA 0.2355 mg/L 3compartmentss NA 95% Human Human +DTXSID40880762 Css NA 0.01656 mg/L PBTK NA 50% Human Human +DTXSID40880762 Css NA 0.1749 mg/L PBTK NA 95% Human Human +DTXSID40880762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880762 Fup 0.821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880762 Vd NA 1.039 L/kg 1compartment NA NA Rat Human +DTXSID40880762 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40880762 TK.Half.Life NA 0.3745 hours 1compartment NA NA Rat Human +DTXSID40880762 Css NA 0.0006811 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880762 Css NA 0.009503 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880762 Css NA 0.0005865 mg/L PBTK NA 50% Rat Human +DTXSID40880762 Css NA 0.006654 mg/L PBTK NA 95% Rat Human +DTXSID40880808 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880808 Fup 0.0193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880808 Vd NA 3.586 L/kg 1compartment NA NA Human Human +DTXSID40880808 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID40880808 TK.Half.Life NA 108.1 hours 1compartment NA NA Human Human +DTXSID40880808 Css NA 3.259 mg/L 3compartmentss NA 50% Human Human +DTXSID40880808 Css NA 19.17 mg/L 3compartmentss NA 95% Human Human +DTXSID40880808 Css NA 2.36 mg/L PBTK NA 50% Human Human +DTXSID40880808 Css NA 13.57 mg/L PBTK NA 95% Human Human +DTXSID40880808 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880808 Fup 0.0193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880808 Vd NA 2.702 L/kg 1compartment NA NA Rat Human +DTXSID40880808 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID40880808 TK.Half.Life NA 14.49 hours 1compartment NA NA Rat Human +DTXSID40880808 Css NA 0.4299 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880808 Css NA 2.131 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880808 Css NA 0.3075 mg/L PBTK NA 50% Rat Human +DTXSID40880808 Css NA 1.584 mg/L PBTK NA 95% Rat Human +DTXSID40880868 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880868 Fup 0.0489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880868 Vd NA 3.09 L/kg 1compartment NA NA Human Human +DTXSID40880868 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID40880868 TK.Half.Life NA 62.67 hours 1compartment NA NA Human Human +DTXSID40880868 Css NA 2.394 mg/L 3compartmentss NA 50% Human Human +DTXSID40880868 Css NA 16.01 mg/L 3compartmentss NA 95% Human Human +DTXSID40880868 Css NA 1.657 mg/L PBTK NA 50% Human Human +DTXSID40880868 Css NA 10.81 mg/L PBTK NA 95% Human Human +DTXSID40880868 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880868 Fup 0.0489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880868 Vd NA 2.316 L/kg 1compartment NA NA Rat Human +DTXSID40880868 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID40880868 TK.Half.Life NA 8.944 hours 1compartment NA NA Rat Human +DTXSID40880868 Css NA 0.3109 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880868 Css NA 1.719 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880868 Css NA 0.2135 mg/L PBTK NA 50% Rat Human +DTXSID40880868 Css NA 1.162 mg/L PBTK NA 95% Rat Human +DTXSID40880888 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880888 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880888 Vd NA 125.4 L/kg 1compartment NA NA Human Human +DTXSID40880888 Days.Css NA 978 Days PBTK NA NA Human Human +DTXSID40880888 TK.Half.Life NA 3691 hours 1compartment NA NA Human Human +DTXSID40880888 Css NA 0.1491 mg/L 3compartmentss NA 50% Human Human +DTXSID40880888 Css NA 0.9645 mg/L 3compartmentss NA 95% Human Human +DTXSID40880888 Css NA 2.36 mg/L PBTK NA 50% Human Human +DTXSID40880888 Css NA 13.61 mg/L PBTK NA 95% Human Human +DTXSID40880888 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880888 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880888 Vd NA 109.2 L/kg 1compartment NA NA Rat Human +DTXSID40880888 Days.Css NA 613 Days PBTK NA NA Rat Human +DTXSID40880888 TK.Half.Life NA 553.2 hours 1compartment NA NA Rat Human +DTXSID40880888 Css NA 0.0179 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880888 Css NA 0.08377 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880888 Css NA 0.3085 mg/L PBTK NA 50% Rat Human +DTXSID40880888 Css NA 1.554 mg/L PBTK NA 95% Rat Human +DTXSID40880904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880904 Fup 0.026 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880904 Vd NA 1.884 L/kg 1compartment NA NA Human Human +DTXSID40880904 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40880904 TK.Half.Life NA 15.59 hours 1compartment NA NA Human Human +DTXSID40880904 Css NA 1.199 mg/L 3compartmentss NA 50% Human Human +DTXSID40880904 Css NA 9.715 mg/L 3compartmentss NA 95% Human Human +DTXSID40880904 Css NA 0.7706 mg/L PBTK NA 50% Human Human +DTXSID40880904 Css NA 6.042 mg/L PBTK NA 95% Human Human +DTXSID40880904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880904 Fup 0.026 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880904 Vd NA 1.402 L/kg 1compartment NA NA Rat Human +DTXSID40880904 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40880904 TK.Half.Life NA 5.271 hours 1compartment NA NA Rat Human +DTXSID40880904 Css NA 0.156 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880904 Css NA 1.048 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880904 Css NA 0.09784 mg/L PBTK NA 50% Rat Human +DTXSID40880904 Css NA 0.6187 mg/L PBTK NA 95% Rat Human +DTXSID40880909 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880909 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880909 Vd NA 2.276 L/kg 1compartment NA NA Human Human +DTXSID40880909 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40880909 TK.Half.Life NA 6.064 hours 1compartment NA NA Human Human +DTXSID40880909 Css NA 0.2372 mg/L 3compartmentss NA 50% Human Human +DTXSID40880909 Css NA 1.618 mg/L 3compartmentss NA 95% Human Human +DTXSID40880909 Css NA 0.1688 mg/L PBTK NA 50% Human Human +DTXSID40880909 Css NA 1.092 mg/L PBTK NA 95% Human Human +DTXSID40880909 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880909 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880909 Vd NA 1.734 L/kg 1compartment NA NA Rat Human +DTXSID40880909 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40880909 TK.Half.Life NA 1.844 hours 1compartment NA NA Rat Human +DTXSID40880909 Css NA 0.03033 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880909 Css NA 0.1538 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880909 Css NA 0.02131 mg/L PBTK NA 50% Rat Human +DTXSID40880909 Css NA 0.1032 mg/L PBTK NA 95% Rat Human +DTXSID40880924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880924 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880924 Vd NA 2.919 L/kg 1compartment NA NA Human Human +DTXSID40880924 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40880924 TK.Half.Life NA 21.29 hours 1compartment NA NA Human Human +DTXSID40880924 Css NA 0.8195 mg/L 3compartmentss NA 50% Human Human +DTXSID40880924 Css NA 5.247 mg/L 3compartmentss NA 95% Human Human +DTXSID40880924 Css NA 0.5738 mg/L PBTK NA 50% Human Human +DTXSID40880924 Css NA 3.536 mg/L PBTK NA 95% Human Human +DTXSID40880924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880924 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880924 Vd NA 2.195 L/kg 1compartment NA NA Rat Human +DTXSID40880924 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID40880924 TK.Half.Life NA 3.997 hours 1compartment NA NA Rat Human +DTXSID40880924 Css NA 0.1057 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880924 Css NA 0.5602 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880924 Css NA 0.07265 mg/L PBTK NA 50% Rat Human +DTXSID40880924 Css NA 0.3718 mg/L PBTK NA 95% Rat Human +DTXSID40880929 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880929 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40880929 Vd NA 0.5996 L/kg 1compartment NA NA Human Human +DTXSID40880929 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40880929 TK.Half.Life NA 0.945 hours 1compartment NA NA Human Human +DTXSID40880929 Css NA 0.09796 mg/L 3compartmentss NA 50% Human Human +DTXSID40880929 Css NA 0.6903 mg/L 3compartmentss NA 95% Human Human +DTXSID40880929 Css NA 0.06995 mg/L PBTK NA 50% Human Human +DTXSID40880929 Css NA 0.4569 mg/L PBTK NA 95% Human Human +DTXSID40880929 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880929 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40880929 Vd NA 0.5498 L/kg 1compartment NA NA Rat Human +DTXSID40880929 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40880929 TK.Half.Life NA 0.4777 hours 1compartment NA NA Rat Human +DTXSID40880929 Css NA 0.01241 mg/L 3compartmentss NA 50% Rat Human +DTXSID40880929 Css NA 0.0666 mg/L 3compartmentss NA 95% Rat Human +DTXSID40880929 Css NA 0.008786 mg/L PBTK NA 50% Rat Human +DTXSID40880929 Css NA 0.0437 mg/L PBTK NA 95% Rat Human +DTXSID40881214 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40881214 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40881214 Vd NA 2.59 L/kg 1compartment NA NA Human Human +DTXSID40881214 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40881214 TK.Half.Life NA 6.342 hours 1compartment NA NA Human Human +DTXSID40881214 Css NA 0.1975 mg/L 3compartmentss NA 50% Human Human +DTXSID40881214 Css NA 1.268 mg/L 3compartmentss NA 95% Human Human +DTXSID40881214 Css NA 0.1458 mg/L PBTK NA 50% Human Human +DTXSID40881214 Css NA 0.8882 mg/L PBTK NA 95% Human Human +DTXSID40881214 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40881214 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40881214 Vd NA 1.978 L/kg 1compartment NA NA Rat Human +DTXSID40881214 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40881214 TK.Half.Life NA 1.706 hours 1compartment NA NA Rat Human +DTXSID40881214 Css NA 0.02522 mg/L 3compartmentss NA 50% Rat Human +DTXSID40881214 Css NA 0.1207 mg/L 3compartmentss NA 95% Rat Human +DTXSID40881214 Css NA 0.01847 mg/L PBTK NA 50% Rat Human +DTXSID40881214 Css NA 0.08384 mg/L PBTK NA 95% Rat Human +DTXSID40893458 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40893458 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40893458 Vd NA 0.5426 L/kg 1compartment NA NA Human Human +DTXSID40893458 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID40893458 TK.Half.Life NA 10.24 hours 1compartment NA NA Human Human +DTXSID40893458 Css NA 2.085 mg/L 3compartmentss NA 50% Human Human +DTXSID40893458 Css NA 8.626 mg/L 3compartmentss NA 95% Human Human +DTXSID40893458 Css NA 1.503 mg/L PBTK NA 50% Human Human +DTXSID40893458 Css NA 5.448 mg/L PBTK NA 95% Human Human +DTXSID40893458 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40893458 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40893458 Vd NA 0.5399 L/kg 1compartment NA NA Rat Human +DTXSID40893458 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40893458 TK.Half.Life NA 3.462 hours 1compartment NA NA Rat Human +DTXSID40893458 Css NA 0.1345 mg/L 3compartmentss NA 50% Rat Human +DTXSID40893458 Css NA 0.4658 mg/L 3compartmentss NA 95% Rat Human +DTXSID40893458 Css NA 0.09523 mg/L PBTK NA 50% Rat Human +DTXSID40893458 Css NA 0.2839 mg/L PBTK NA 95% Rat Human +DTXSID40909301 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40909301 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40909301 Vd NA 1.099 L/kg 1compartment NA NA Human Human +DTXSID40909301 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40909301 TK.Half.Life NA 2.84 hours 1compartment NA NA Human Human +DTXSID40909301 Css NA 0.234 mg/L 3compartmentss NA 50% Human Human +DTXSID40909301 Css NA 2.138 mg/L 3compartmentss NA 95% Human Human +DTXSID40909301 Css NA 0.1618 mg/L PBTK NA 50% Human Human +DTXSID40909301 Css NA 1.346 mg/L PBTK NA 95% Human Human +DTXSID40909301 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40909301 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40909301 Vd NA 1.087 L/kg 1compartment NA NA Rat Human +DTXSID40909301 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40909301 TK.Half.Life NA 1.698 hours 1compartment NA NA Rat Human +DTXSID40909301 Css NA 0.01136 mg/L 3compartmentss NA 50% Rat Human +DTXSID40909301 Css NA 0.114 mg/L 3compartmentss NA 95% Rat Human +DTXSID40909301 Css NA 0.00769 mg/L PBTK NA 50% Rat Human +DTXSID40909301 Css NA 0.06991 mg/L PBTK NA 95% Rat Human +DTXSID40938196 Clint 50.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40938196 Fup 0.0828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40938196 Vd NA 0.7177 L/kg 1compartment NA NA Human Human +DTXSID40938196 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID40938196 TK.Half.Life NA 1.285 hours 1compartment NA NA Human Human +DTXSID40938196 Css NA 0.1512 mg/L 3compartmentss NA 50% Human Human +DTXSID40938196 Css NA 1.31 mg/L 3compartmentss NA 95% Human Human +DTXSID40938196 Css NA 0.09516 mg/L PBTK NA 50% Human Human +DTXSID40938196 Css NA 0.7852 mg/L PBTK NA 95% Human Human +DTXSID40938196 Clint 50.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40938196 Fup 0.0828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40938196 Vd NA 0.5797 L/kg 1compartment NA NA Rat Human +DTXSID40938196 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID40938196 TK.Half.Life NA 0.5682 hours 1compartment NA NA Rat Human +DTXSID40938196 Css NA 0.01999 mg/L 3compartmentss NA 50% Rat Human +DTXSID40938196 Css NA 0.1329 mg/L 3compartmentss NA 95% Rat Human +DTXSID40938196 Css NA 0.0122 mg/L PBTK NA 50% Rat Human +DTXSID40938196 Css NA 0.07876 mg/L PBTK NA 95% Rat Human +DTXSID40961762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID40961762 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID40961762 Vd NA 3.144 L/kg 1compartment NA NA Human Human +DTXSID40961762 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID40961762 TK.Half.Life NA 36.12 hours 1compartment NA NA Human Human +DTXSID40961762 Css NA 1.129 mg/L 3compartmentss NA 50% Human Human +DTXSID40961762 Css NA 8.163 mg/L 3compartmentss NA 95% Human Human +DTXSID40961762 Css NA 0.7961 mg/L PBTK NA 50% Human Human +DTXSID40961762 Css NA 5.599 mg/L PBTK NA 95% Human Human +DTXSID40961762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID40961762 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID40961762 Vd NA 2.362 L/kg 1compartment NA NA Rat Human +DTXSID40961762 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID40961762 TK.Half.Life NA 5.063 hours 1compartment NA NA Rat Human +DTXSID40961762 Css NA 0.05846 mg/L 3compartmentss NA 50% Rat Human +DTXSID40961762 Css NA 0.3995 mg/L 3compartmentss NA 95% Rat Human +DTXSID40961762 Css NA 0.04024 mg/L PBTK NA 50% Rat Human +DTXSID40961762 Css NA 0.2606 mg/L PBTK NA 95% Rat Human +DTXSID501018140 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID501018140 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID501018140 Vd NA 0.4931 L/kg 1compartment NA NA Human Human DTXSID501018140 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID501018140 TK.Half.Life NA 10.07 hours 1compartment NA NA Human Human -DTXSID501018140 Css NA 2.234 mg/L 3compartmentss NA 50% Human Human -DTXSID501018140 Css NA 8.943 mg/L 3compartmentss NA 95% Human Human -DTXSID501018140 Css NA 1.603 mg/L PBTK NA 50% Human Human -DTXSID501018140 Css NA 5.656 mg/L PBTK NA 95% Human Human -DTXSID501018140 Clint NA 0.06807 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID501018140 Fup NA 0.2941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID501018140 Vd NA 0.5153 L/kg 1compartment NA NA Rat Human +DTXSID501018140 TK.Half.Life NA 13.18 hours 1compartment NA NA Human Human +DTXSID501018140 Css NA 1.642 mg/L 3compartmentss NA 50% Human Human +DTXSID501018140 Css NA 7.035 mg/L 3compartmentss NA 95% Human Human +DTXSID501018140 Css NA 1.163 mg/L PBTK NA 50% Human Human +DTXSID501018140 Css NA 4.431 mg/L PBTK NA 95% Human Human +DTXSID501018140 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID501018140 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID501018140 Vd NA 0.4952 L/kg 1compartment NA NA Rat Human DTXSID501018140 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID501018140 TK.Half.Life NA 3.66 hours 1compartment NA NA Rat Human -DTXSID501018140 Css NA 0.6537 mg/L 3compartmentss NA 50% Rat Human -DTXSID501018140 Css NA 2.263 mg/L 3compartmentss NA 95% Rat Human -DTXSID501018140 Css NA 0.4469 mg/L PBTK NA 50% Rat Human -DTXSID501018140 Css NA 1.332 mg/L PBTK NA 95% Rat Human -DTXSID5020021 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID501018140 TK.Half.Life NA 4.513 hours 1compartment NA NA Rat Human +DTXSID501018140 Css NA 0.008812 mg/L 3compartmentss NA 50% Rat Human +DTXSID501018140 Css NA 0.03731 mg/L 3compartmentss NA 95% Rat Human +DTXSID501018140 Css NA 0.005938 mg/L PBTK NA 50% Rat Human +DTXSID501018140 Css NA 0.02253 mg/L PBTK NA 95% Rat Human +DTXSID50110042 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50110042 Fup 0.0199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50110042 Vd NA 2.937 L/kg 1compartment NA NA Human Human +DTXSID50110042 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID50110042 TK.Half.Life NA 53.73 hours 1compartment NA NA Human Human +DTXSID50110042 Css NA 2.056 mg/L 3compartmentss NA 50% Human Human +DTXSID50110042 Css NA 13.36 mg/L 3compartmentss NA 95% Human Human +DTXSID50110042 Css NA 1.396 mg/L PBTK NA 50% Human Human +DTXSID50110042 Css NA 8.789 mg/L PBTK NA 95% Human Human +DTXSID50110042 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50110042 Fup 0.0199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50110042 Vd NA 2.199 L/kg 1compartment NA NA Rat Human +DTXSID50110042 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID50110042 TK.Half.Life NA 9.188 hours 1compartment NA NA Rat Human +DTXSID50110042 Css NA 0.104 mg/L 3compartmentss NA 50% Rat Human +DTXSID50110042 Css NA 0.7119 mg/L 3compartmentss NA 95% Rat Human +DTXSID50110042 Css NA 0.06925 mg/L PBTK NA 50% Rat Human +DTXSID50110042 Css NA 0.4553 mg/L PBTK NA 95% Rat Human +DTXSID501104846 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID501104846 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID501104846 Vd NA 0.7951 L/kg 1compartment NA NA Human Human +DTXSID501104846 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID501104846 TK.Half.Life NA 3.212 hours 1compartment NA NA Human Human +DTXSID501104846 Css NA 0.416 mg/L 3compartmentss NA 50% Human Human +DTXSID501104846 Css NA 2.366 mg/L 3compartmentss NA 95% Human Human +DTXSID501104846 Css NA 0.2834 mg/L PBTK NA 50% Human Human +DTXSID501104846 Css NA 1.522 mg/L PBTK NA 95% Human Human +DTXSID501104846 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID501104846 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID501104846 Vd NA 0.6716 L/kg 1compartment NA NA Rat Human +DTXSID501104846 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID501104846 TK.Half.Life NA 1.555 hours 1compartment NA NA Rat Human +DTXSID501104846 Css NA 0.04812 mg/L 3compartmentss NA 50% Rat Human +DTXSID501104846 Css NA 0.2044 mg/L 3compartmentss NA 95% Rat Human +DTXSID501104846 Css NA 0.03228 mg/L PBTK NA 50% Rat Human +DTXSID501104846 Css NA 0.1261 mg/L PBTK NA 95% Rat Human +DTXSID501123076 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID501123076 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID501123076 Vd NA 0.4781 L/kg 1compartment NA NA Human Human +DTXSID501123076 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID501123076 TK.Half.Life NA 2.544 hours 1compartment NA NA Human Human +DTXSID501123076 Css NA 0.1056 mg/L 3compartmentss NA 50% Human Human +DTXSID501123076 Css NA 0.9163 mg/L 3compartmentss NA 95% Human Human +DTXSID501123076 Css NA 0.07123 mg/L PBTK NA 50% Human Human +DTXSID501123076 Css NA 0.5651 mg/L PBTK NA 95% Human Human +DTXSID501123076 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID501123076 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID501123076 Vd NA 0.4705 L/kg 1compartment NA NA Rat Human +DTXSID501123076 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID501123076 TK.Half.Life NA 1.518 hours 1compartment NA NA Rat Human +DTXSID501123076 Css NA 0.0008478 mg/L 3compartmentss NA 50% Rat Human +DTXSID501123076 Css NA 0.005257 mg/L 3compartmentss NA 95% Rat Human +DTXSID501123076 Css NA 0.0005402 mg/L PBTK NA 50% Rat Human +DTXSID501123076 Css NA 0.00304 mg/L PBTK NA 95% Rat Human +DTXSID501123595 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID501123595 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID501123595 Vd NA 0.9196 L/kg 1compartment NA NA Human Human +DTXSID501123595 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID501123595 TK.Half.Life NA 1.957 hours 1compartment NA NA Human Human +DTXSID501123595 Css NA 0.1678 mg/L 3compartmentss NA 50% Human Human +DTXSID501123595 Css NA 1.151 mg/L 3compartmentss NA 95% Human Human +DTXSID501123595 Css NA 0.1284 mg/L PBTK NA 50% Human Human +DTXSID501123595 Css NA 0.7793 mg/L PBTK NA 95% Human Human +DTXSID501123595 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID501123595 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID501123595 Vd NA 0.8318 L/kg 1compartment NA NA Rat Human +DTXSID501123595 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID501123595 TK.Half.Life NA 0.973 hours 1compartment NA NA Rat Human +DTXSID501123595 Css NA 0.01946 mg/L 3compartmentss NA 50% Rat Human +DTXSID501123595 Css NA 0.09502 mg/L 3compartmentss NA 95% Rat Human +DTXSID501123595 Css NA 0.01507 mg/L PBTK NA 50% Rat Human +DTXSID501123595 Css NA 0.06234 mg/L PBTK NA 95% Rat Human +DTXSID50143299 Clint 2.221 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50143299 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50143299 Vd NA 0.2093 L/kg 1compartment NA NA Human Human +DTXSID50143299 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50143299 TK.Half.Life NA 2.783 hours 1compartment NA NA Human Human +DTXSID50143299 Css NA 1.143 mg/L 3compartmentss NA 50% Human Human +DTXSID50143299 Css NA 7.264 mg/L 3compartmentss NA 95% Human Human +DTXSID50143299 Css NA 0.6859 mg/L PBTK NA 50% Human Human +DTXSID50143299 Css NA 4.228 mg/L PBTK NA 95% Human Human +DTXSID50143299 Clint 2.221 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50143299 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50143299 Vd NA 0.2124 L/kg 1compartment NA NA Rat Human +DTXSID50143299 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50143299 TK.Half.Life NA 1.594 hours 1compartment NA NA Rat Human +DTXSID50143299 Css NA 0.01067 mg/L 3compartmentss NA 50% Rat Human +DTXSID50143299 Css NA 0.05779 mg/L 3compartmentss NA 95% Rat Human +DTXSID50143299 Css NA 0.005992 mg/L PBTK NA 50% Rat Human +DTXSID50143299 Css NA 0.03174 mg/L PBTK NA 95% Rat Human +DTXSID50146982 Clint 6.294 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50146982 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50146982 Vd NA 0.7847 L/kg 1compartment NA NA Human Human +DTXSID50146982 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50146982 TK.Half.Life NA 1.899 hours 1compartment NA NA Human Human +DTXSID50146982 Css NA 0.2016 mg/L 3compartmentss NA 50% Human Human +DTXSID50146982 Css NA 1.319 mg/L 3compartmentss NA 95% Human Human +DTXSID50146982 Css NA 0.1486 mg/L PBTK NA 50% Human Human +DTXSID50146982 Css NA 0.8713 mg/L PBTK NA 95% Human Human +DTXSID50146982 Clint 6.294 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50146982 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50146982 Vd NA 0.7158 L/kg 1compartment NA NA Rat Human +DTXSID50146982 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50146982 TK.Half.Life NA 0.9705 hours 1compartment NA NA Rat Human +DTXSID50146982 Css NA 0.02422 mg/L 3compartmentss NA 50% Rat Human +DTXSID50146982 Css NA 0.1139 mg/L 3compartmentss NA 95% Rat Human +DTXSID50146982 Css NA 0.0177 mg/L PBTK NA 50% Rat Human +DTXSID50146982 Css NA 0.07331 mg/L PBTK NA 95% Rat Human +DTXSID50147939 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50147939 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50147939 Vd NA 0.6015 L/kg 1compartment NA NA Human Human +DTXSID50147939 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50147939 TK.Half.Life NA 7.086 hours 1compartment NA NA Human Human +DTXSID50147939 Css NA 1.322 mg/L 3compartmentss NA 50% Human Human +DTXSID50147939 Css NA 8.307 mg/L 3compartmentss NA 95% Human Human +DTXSID50147939 Css NA 1.015 mg/L PBTK NA 50% Human Human +DTXSID50147939 Css NA 5.259 mg/L PBTK NA 95% Human Human +DTXSID50147939 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50147939 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50147939 Vd NA 0.6183 L/kg 1compartment NA NA Rat Human +DTXSID50147939 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50147939 TK.Half.Life NA 2.48 hours 1compartment NA NA Rat Human +DTXSID50147939 Css NA 0.08132 mg/L 3compartmentss NA 50% Rat Human +DTXSID50147939 Css NA 0.4849 mg/L 3compartmentss NA 95% Rat Human +DTXSID50147939 Css NA 0.06222 mg/L PBTK NA 50% Rat Human +DTXSID50147939 Css NA 0.2925 mg/L PBTK NA 95% Rat Human +DTXSID50148507 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50148507 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50148507 Vd NA 4.383 L/kg 1compartment NA NA Human Human +DTXSID50148507 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50148507 TK.Half.Life NA 5.559 hours 1compartment NA NA Human Human +DTXSID50148507 Css NA 0.06253 mg/L 3compartmentss NA 50% Human Human +DTXSID50148507 Css NA 0.4438 mg/L 3compartmentss NA 95% Human Human +DTXSID50148507 Css NA 0.0669 mg/L PBTK NA 50% Human Human +DTXSID50148507 Css NA 0.4159 mg/L PBTK NA 95% Human Human +DTXSID50148507 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50148507 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50148507 Vd NA 3.971 L/kg 1compartment NA NA Rat Human +DTXSID50148507 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50148507 TK.Half.Life NA 1.872 hours 1compartment NA NA Rat Human +DTXSID50148507 Css NA 0.007649 mg/L 3compartmentss NA 50% Rat Human +DTXSID50148507 Css NA 0.04295 mg/L 3compartmentss NA 95% Rat Human +DTXSID50148507 Css NA 0.008504 mg/L PBTK NA 50% Rat Human +DTXSID50148507 Css NA 0.04159 mg/L PBTK NA 95% Rat Human +DTXSID50149493 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50149493 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50149493 Vd NA 3.103 L/kg 1compartment NA NA Human Human +DTXSID50149493 Days.Css NA 50 Days PBTK NA NA Human Human +DTXSID50149493 TK.Half.Life NA 239.1 hours 1compartment NA NA Human Human +DTXSID50149493 Css NA 9.042 mg/L 3compartmentss NA 50% Human Human +DTXSID50149493 Css NA 48.61 mg/L 3compartmentss NA 95% Human Human +DTXSID50149493 Css NA 6.357 mg/L PBTK NA 50% Human Human +DTXSID50149493 Css NA 33.37 mg/L PBTK NA 95% Human Human +DTXSID50149493 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50149493 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50149493 Vd NA 2.335 L/kg 1compartment NA NA Rat Human +DTXSID50149493 Days.Css NA 25 Days PBTK NA NA Rat Human +DTXSID50149493 TK.Half.Life NA 31.69 hours 1compartment NA NA Rat Human +DTXSID50149493 Css NA 1.102 mg/L 3compartmentss NA 50% Rat Human +DTXSID50149493 Css NA 4.332 mg/L 3compartmentss NA 95% Rat Human +DTXSID50149493 Css NA 0.7708 mg/L PBTK NA 50% Rat Human +DTXSID50149493 Css NA 2.921 mg/L PBTK NA 95% Rat Human +DTXSID50152604 Clint 11 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID50152604 Fup 0.024 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50152604 Vd NA 0.2491 L/kg 1compartment NA NA Human Human +DTXSID50152604 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50152604 TK.Half.Life NA 3.711 hours 1compartment NA NA Human Human +DTXSID50152604 Css NA 1.396 mg/L 3compartmentss NA 50% Human Human +DTXSID50152604 Css NA 14.19 mg/L 3compartmentss NA 95% Human Human +DTXSID50152604 Css NA 0.8344 mg/L PBTK NA 50% Human Human +DTXSID50152604 Css NA 8.279 mg/L PBTK NA 95% Human Human +DTXSID50152604 Clint 11 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID50152604 Fup 0.024 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50152604 Vd NA 0.2434 L/kg 1compartment NA NA Rat Human +DTXSID50152604 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50152604 TK.Half.Life NA 2.355 hours 1compartment NA NA Rat Human +DTXSID50152604 Css NA 0.01499 mg/L 3compartmentss NA 50% Rat Human +DTXSID50152604 Css NA 0.1335 mg/L 3compartmentss NA 95% Rat Human +DTXSID50152604 Css NA 0.008368 mg/L PBTK NA 50% Rat Human +DTXSID50152604 Css NA 0.07331 mg/L PBTK NA 95% Rat Human +DTXSID50154840 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50154840 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50154840 Vd NA 2.618 L/kg 1compartment NA NA Human Human +DTXSID50154840 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID50154840 TK.Half.Life NA 73.56 hours 1compartment NA NA Human Human +DTXSID50154840 Css NA 3.941 mg/L 3compartmentss NA 50% Human Human +DTXSID50154840 Css NA 27.31 mg/L 3compartmentss NA 95% Human Human +DTXSID50154840 Css NA 2.606 mg/L PBTK NA 50% Human Human +DTXSID50154840 Css NA 17.65 mg/L PBTK NA 95% Human Human +DTXSID50154840 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50154840 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50154840 Vd NA 1.95 L/kg 1compartment NA NA Rat Human +DTXSID50154840 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID50154840 TK.Half.Life NA 16.41 hours 1compartment NA NA Rat Human +DTXSID50154840 Css NA 0.5154 mg/L 3compartmentss NA 50% Rat Human +DTXSID50154840 Css NA 3.015 mg/L 3compartmentss NA 95% Rat Human +DTXSID50154840 Css NA 0.3335 mg/L PBTK NA 50% Rat Human +DTXSID50154840 Css NA 1.909 mg/L PBTK NA 95% Rat Human +DTXSID50163295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50163295 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50163295 Vd NA 1.435 L/kg 1compartment NA NA Human Human +DTXSID50163295 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID50163295 TK.Half.Life NA 19.47 hours 1compartment NA NA Human Human +DTXSID50163295 Css NA 1.185 mg/L 3compartmentss NA 50% Human Human +DTXSID50163295 Css NA 8.1 mg/L 3compartmentss NA 95% Human Human +DTXSID50163295 Css NA 1.013 mg/L PBTK NA 50% Human Human +DTXSID50163295 Css NA 5.267 mg/L PBTK NA 95% Human Human +DTXSID50163295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50163295 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50163295 Vd NA 1.237 L/kg 1compartment NA NA Rat Human +DTXSID50163295 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50163295 TK.Half.Life NA 5.074 hours 1compartment NA NA Rat Human +DTXSID50163295 Css NA 0.02194 mg/L 3compartmentss NA 50% Rat Human +DTXSID50163295 Css NA 0.1969 mg/L 3compartmentss NA 95% Rat Human +DTXSID50163295 Css NA 0.01808 mg/L PBTK NA 50% Rat Human +DTXSID50163295 Css NA 0.128 mg/L PBTK NA 95% Rat Human +DTXSID50165456 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50165456 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50165456 Vd NA 0.231 L/kg 1compartment NA NA Human Human +DTXSID50165456 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50165456 TK.Half.Life NA 1.498 hours 1compartment NA NA Human Human +DTXSID50165456 Css NA 0.5224 mg/L 3compartmentss NA 50% Human Human +DTXSID50165456 Css NA 3.945 mg/L 3compartmentss NA 95% Human Human +DTXSID50165456 Css NA 0.3154 mg/L PBTK NA 50% Human Human +DTXSID50165456 Css NA 2.285 mg/L PBTK NA 95% Human Human +DTXSID50165456 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50165456 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50165456 Vd NA 0.231 L/kg 1compartment NA NA Rat Human +DTXSID50165456 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50165456 TK.Half.Life NA 0.9118 hours 1compartment NA NA Rat Human +DTXSID50165456 Css NA 0.005338 mg/L 3compartmentss NA 50% Rat Human +DTXSID50165456 Css NA 0.03274 mg/L 3compartmentss NA 95% Rat Human +DTXSID50165456 Css NA 0.003034 mg/L PBTK NA 50% Rat Human +DTXSID50165456 Css NA 0.0181 mg/L PBTK NA 95% Rat Human +DTXSID50165552 Clint 42.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50165552 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50165552 Vd NA 2.738 L/kg 1compartment NA NA Human Human +DTXSID50165552 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50165552 TK.Half.Life NA 5.173 hours 1compartment NA NA Human Human +DTXSID50165552 Css NA 0.1309 mg/L 3compartmentss NA 50% Human Human +DTXSID50165552 Css NA 0.8865 mg/L 3compartmentss NA 95% Human Human +DTXSID50165552 Css NA 0.09557 mg/L PBTK NA 50% Human Human +DTXSID50165552 Css NA 0.6187 mg/L PBTK NA 95% Human Human +DTXSID50165552 Clint 42.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50165552 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50165552 Vd NA 2.082 L/kg 1compartment NA NA Rat Human +DTXSID50165552 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50165552 TK.Half.Life NA 1.347 hours 1compartment NA NA Rat Human +DTXSID50165552 Css NA 0.01668 mg/L 3compartmentss NA 50% Rat Human +DTXSID50165552 Css NA 0.09213 mg/L 3compartmentss NA 95% Rat Human +DTXSID50165552 Css NA 0.01215 mg/L PBTK NA 50% Rat Human +DTXSID50165552 Css NA 0.06393 mg/L PBTK NA 95% Rat Human +DTXSID50165895 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50165895 Fup 0.76 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50165895 Vd NA 0.5486 L/kg 1compartment NA NA Human Human +DTXSID50165895 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50165895 TK.Half.Life NA 4.671 hours 1compartment NA NA Human Human +DTXSID50165895 Css NA 0.6518 mg/L 3compartmentss NA 50% Human Human +DTXSID50165895 Css NA 3.964 mg/L 3compartmentss NA 95% Human Human +DTXSID50165895 Css NA 0.5104 mg/L PBTK NA 50% Human Human +DTXSID50165895 Css NA 2.52 mg/L PBTK NA 95% Human Human +DTXSID50165895 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50165895 Fup 0.76 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50165895 Vd NA 0.5675 L/kg 1compartment NA NA Rat Human +DTXSID50165895 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50165895 TK.Half.Life NA 1.646 hours 1compartment NA NA Rat Human +DTXSID50165895 Css NA 0.003805 mg/L 3compartmentss NA 50% Rat Human +DTXSID50165895 Css NA 0.02764 mg/L 3compartmentss NA 95% Rat Human +DTXSID50165895 Css NA 0.002858 mg/L PBTK NA 50% Rat Human +DTXSID50165895 Css NA 0.01686 mg/L PBTK NA 95% Rat Human +DTXSID50166423 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50166423 Fup 0.358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50166423 Vd NA 0.5773 L/kg 1compartment NA NA Human Human +DTXSID50166423 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID50166423 TK.Half.Life NA 10.5 hours 1compartment NA NA Human Human +DTXSID50166423 Css NA 1.992 mg/L 3compartmentss NA 50% Human Human +DTXSID50166423 Css NA 8.164 mg/L 3compartmentss NA 95% Human Human +DTXSID50166423 Css NA 1.459 mg/L PBTK NA 50% Human Human +DTXSID50166423 Css NA 5.157 mg/L PBTK NA 95% Human Human +DTXSID50166423 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50166423 Fup 0.358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50166423 Vd NA 0.5682 L/kg 1compartment NA NA Rat Human +DTXSID50166423 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50166423 TK.Half.Life NA 3.504 hours 1compartment NA NA Rat Human +DTXSID50166423 Css NA 0.1284 mg/L 3compartmentss NA 50% Rat Human +DTXSID50166423 Css NA 0.4493 mg/L 3compartmentss NA 95% Rat Human +DTXSID50166423 Css NA 0.09204 mg/L PBTK NA 50% Rat Human +DTXSID50166423 Css NA 0.2751 mg/L PBTK NA 95% Rat Human +DTXSID50168008 Clint 12 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID50168008 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50168008 Vd NA 0.1664 L/kg 1compartment NA NA Human Human +DTXSID50168008 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID50168008 TK.Half.Life NA 50.01 hours 1compartment NA NA Human Human +DTXSID50168008 Css NA 30.1 mg/L 3compartmentss NA 50% Human Human +DTXSID50168008 Css NA 272.2 mg/L 3compartmentss NA 95% Human Human +DTXSID50168008 Css NA 17.57 mg/L PBTK NA 50% Human Human +DTXSID50168008 Css NA 156.2 mg/L PBTK NA 95% Human Human +DTXSID50168008 Clint 12 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID50168008 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50168008 Vd NA 0.1621 L/kg 1compartment NA NA Rat Human +DTXSID50168008 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID50168008 TK.Half.Life NA 32.57 hours 1compartment NA NA Rat Human +DTXSID50168008 Css NA 0.3387 mg/L 3compartmentss NA 50% Rat Human +DTXSID50168008 Css NA 2.617 mg/L 3compartmentss NA 95% Rat Human +DTXSID50168008 Css NA 0.1834 mg/L PBTK NA 50% Rat Human +DTXSID50168008 Css NA 1.42 mg/L PBTK NA 95% Rat Human +DTXSID50171375 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50171375 Fup 0.0229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50171375 Vd NA 3.057 L/kg 1compartment NA NA Human Human +DTXSID50171375 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID50171375 TK.Half.Life NA 68.09 hours 1compartment NA NA Human Human +DTXSID50171375 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human +DTXSID50171375 Css NA 10.55 mg/L 3compartmentss NA 95% Human Human +DTXSID50171375 Css NA 1.028 mg/L PBTK NA 50% Human Human +DTXSID50171375 Css NA 7.077 mg/L PBTK NA 95% Human Human +DTXSID50171375 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50171375 Fup 0.0229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50171375 Vd NA 2.29 L/kg 1compartment NA NA Rat Human +DTXSID50171375 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID50171375 TK.Half.Life NA 10.08 hours 1compartment NA NA Rat Human +DTXSID50171375 Css NA 0.01612 mg/L 3compartmentss NA 50% Rat Human +DTXSID50171375 Css NA 0.1039 mg/L 3compartmentss NA 95% Rat Human +DTXSID50171375 Css NA 0.01064 mg/L PBTK NA 50% Rat Human +DTXSID50171375 Css NA 0.06802 mg/L PBTK NA 95% Rat Human +DTXSID50171996 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50171996 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50171996 Vd NA 0.4924 L/kg 1compartment NA NA Human Human +DTXSID50171996 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50171996 TK.Half.Life NA 3.285 hours 1compartment NA NA Human Human +DTXSID50171996 Css NA 0.5349 mg/L 3compartmentss NA 50% Human Human +DTXSID50171996 Css NA 2.992 mg/L 3compartmentss NA 95% Human Human +DTXSID50171996 Css NA 0.4024 mg/L PBTK NA 50% Human Human +DTXSID50171996 Css NA 1.882 mg/L PBTK NA 95% Human Human +DTXSID50171996 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50171996 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50171996 Vd NA 0.5237 L/kg 1compartment NA NA Rat Human +DTXSID50171996 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50171996 TK.Half.Life NA 1.191 hours 1compartment NA NA Rat Human +DTXSID50171996 Css NA 0.00278 mg/L 3compartmentss NA 50% Rat Human +DTXSID50171996 Css NA 0.01576 mg/L 3compartmentss NA 95% Rat Human +DTXSID50171996 Css NA 0.002025 mg/L PBTK NA 50% Rat Human +DTXSID50171996 Css NA 0.009519 mg/L PBTK NA 95% Rat Human +DTXSID50175232 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50175232 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50175232 Vd NA 0.2954 L/kg 1compartment NA NA Human Human +DTXSID50175232 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50175232 TK.Half.Life NA 1.209 hours 1compartment NA NA Human Human +DTXSID50175232 Css NA 0.2336 mg/L 3compartmentss NA 50% Human Human +DTXSID50175232 Css NA 1.509 mg/L 3compartmentss NA 95% Human Human +DTXSID50175232 Css NA 0.1488 mg/L PBTK NA 50% Human Human +DTXSID50175232 Css NA 0.9162 mg/L PBTK NA 95% Human Human +DTXSID50175232 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50175232 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50175232 Vd NA 0.2978 L/kg 1compartment NA NA Rat Human +DTXSID50175232 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50175232 TK.Half.Life NA 0.7238 hours 1compartment NA NA Rat Human +DTXSID50175232 Css NA 0.0023 mg/L 3compartmentss NA 50% Rat Human +DTXSID50175232 Css NA 0.01252 mg/L 3compartmentss NA 95% Rat Human +DTXSID50175232 Css NA 0.001392 mg/L PBTK NA 50% Rat Human +DTXSID50175232 Css NA 0.00718 mg/L PBTK NA 95% Rat Human +DTXSID50175419 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50175419 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50175419 Vd NA 2.963 L/kg 1compartment NA NA Human Human +DTXSID50175419 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50175419 TK.Half.Life NA 11.49 hours 1compartment NA NA Human Human +DTXSID50175419 Css NA 0.3142 mg/L 3compartmentss NA 50% Human Human +DTXSID50175419 Css NA 1.932 mg/L 3compartmentss NA 95% Human Human +DTXSID50175419 Css NA 0.2532 mg/L PBTK NA 50% Human Human +DTXSID50175419 Css NA 1.404 mg/L PBTK NA 95% Human Human +DTXSID50175419 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50175419 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50175419 Vd NA 2.324 L/kg 1compartment NA NA Rat Human +DTXSID50175419 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50175419 TK.Half.Life NA 2.526 hours 1compartment NA NA Rat Human +DTXSID50175419 Css NA 0.01452 mg/L 3compartmentss NA 50% Rat Human +DTXSID50175419 Css NA 0.09473 mg/L 3compartmentss NA 95% Rat Human +DTXSID50175419 Css NA 0.01156 mg/L PBTK NA 50% Rat Human +DTXSID50175419 Css NA 0.06968 mg/L PBTK NA 95% Rat Human +DTXSID50175656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50175656 Fup 0.0429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50175656 Vd NA 1.663 L/kg 1compartment NA NA Human Human +DTXSID50175656 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50175656 TK.Half.Life NA 9.069 hours 1compartment NA NA Human Human +DTXSID50175656 Css NA 0.7432 mg/L 3compartmentss NA 50% Human Human +DTXSID50175656 Css NA 6.077 mg/L 3compartmentss NA 95% Human Human +DTXSID50175656 Css NA 0.4771 mg/L PBTK NA 50% Human Human +DTXSID50175656 Css NA 3.71 mg/L PBTK NA 95% Human Human +DTXSID50175656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50175656 Fup 0.0429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50175656 Vd NA 1.244 L/kg 1compartment NA NA Rat Human +DTXSID50175656 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50175656 TK.Half.Life NA 3.328 hours 1compartment NA NA Rat Human +DTXSID50175656 Css NA 0.09693 mg/L 3compartmentss NA 50% Rat Human +DTXSID50175656 Css NA 0.6162 mg/L 3compartmentss NA 95% Rat Human +DTXSID50175656 Css NA 0.06086 mg/L PBTK NA 50% Rat Human +DTXSID50175656 Css NA 0.3665 mg/L PBTK NA 95% Rat Human +DTXSID50176365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50176365 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50176365 Vd NA 1.303 L/kg 1compartment NA NA Human Human +DTXSID50176365 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50176365 TK.Half.Life NA 8.812 hours 1compartment NA NA Human Human +DTXSID50176365 Css NA 0.9814 mg/L 3compartmentss NA 50% Human Human +DTXSID50176365 Css NA 9.422 mg/L 3compartmentss NA 95% Human Human +DTXSID50176365 Css NA 0.6136 mg/L PBTK NA 50% Human Human +DTXSID50176365 Css NA 5.693 mg/L PBTK NA 95% Human Human +DTXSID50176365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50176365 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50176365 Vd NA 0.971 L/kg 1compartment NA NA Rat Human +DTXSID50176365 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50176365 TK.Half.Life NA 3.58 hours 1compartment NA NA Rat Human +DTXSID50176365 Css NA 0.1072 mg/L 3compartmentss NA 50% Rat Human +DTXSID50176365 Css NA 0.8133 mg/L 3compartmentss NA 95% Rat Human +DTXSID50176365 Css NA 0.06493 mg/L PBTK NA 50% Rat Human +DTXSID50176365 Css NA 0.4737 mg/L PBTK NA 95% Rat Human +DTXSID50183271 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50183271 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50183271 Vd NA 4.283 L/kg 1compartment NA NA Human Human +DTXSID50183271 Days.Css NA 24 Days PBTK NA NA Human Human +DTXSID50183271 TK.Half.Life NA 133.7 hours 1compartment NA NA Human Human +DTXSID50183271 Css NA 3.27 mg/L 3compartmentss NA 50% Human Human +DTXSID50183271 Css NA 19.5 mg/L 3compartmentss NA 95% Human Human +DTXSID50183271 Css NA 2.484 mg/L PBTK NA 50% Human Human +DTXSID50183271 Css NA 14.69 mg/L PBTK NA 95% Human Human +DTXSID50183271 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50183271 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50183271 Vd NA 3.251 L/kg 1compartment NA NA Rat Human +DTXSID50183271 Days.Css NA 14 Days PBTK NA NA Rat Human +DTXSID50183271 TK.Half.Life NA 19.94 hours 1compartment NA NA Rat Human +DTXSID50183271 Css NA 0.4234 mg/L 3compartmentss NA 50% Rat Human +DTXSID50183271 Css NA 2.157 mg/L 3compartmentss NA 95% Rat Human +DTXSID50183271 Css NA 0.3231 mg/L PBTK NA 50% Rat Human +DTXSID50183271 Css NA 1.648 mg/L PBTK NA 95% Rat Human +DTXSID50183615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50183615 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50183615 Vd NA 1.233 L/kg 1compartment NA NA Human Human +DTXSID50183615 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50183615 TK.Half.Life NA 1.963 hours 1compartment NA NA Human Human +DTXSID50183615 Css NA 0.101 mg/L 3compartmentss NA 50% Human Human +DTXSID50183615 Css NA 0.7163 mg/L 3compartmentss NA 95% Human Human +DTXSID50183615 Css NA 0.0724 mg/L PBTK NA 50% Human Human +DTXSID50183615 Css NA 0.4747 mg/L PBTK NA 95% Human Human +DTXSID50183615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50183615 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50183615 Vd NA 0.9995 L/kg 1compartment NA NA Rat Human +DTXSID50183615 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50183615 TK.Half.Life NA 0.8194 hours 1compartment NA NA Rat Human +DTXSID50183615 Css NA 0.01137 mg/L 3compartmentss NA 50% Rat Human +DTXSID50183615 Css NA 0.06405 mg/L 3compartmentss NA 95% Rat Human +DTXSID50183615 Css NA 0.0081 mg/L PBTK NA 50% Rat Human +DTXSID50183615 Css NA 0.04217 mg/L PBTK NA 95% Rat Human +DTXSID50187178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50187178 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50187178 Vd NA 3.02 L/kg 1compartment NA NA Human Human +DTXSID50187178 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID50187178 TK.Half.Life NA 74.98 hours 1compartment NA NA Human Human +DTXSID50187178 Css NA 3.069 mg/L 3compartmentss NA 50% Human Human +DTXSID50187178 Css NA 20.15 mg/L 3compartmentss NA 95% Human Human +DTXSID50187178 Css NA 2.111 mg/L PBTK NA 50% Human Human +DTXSID50187178 Css NA 13.64 mg/L PBTK NA 95% Human Human +DTXSID50187178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50187178 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50187178 Vd NA 2.26 L/kg 1compartment NA NA Rat Human +DTXSID50187178 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID50187178 TK.Half.Life NA 11.54 hours 1compartment NA NA Rat Human +DTXSID50187178 Css NA 0.3994 mg/L 3compartmentss NA 50% Rat Human +DTXSID50187178 Css NA 2.317 mg/L 3compartmentss NA 95% Rat Human +DTXSID50187178 Css NA 0.2704 mg/L PBTK NA 50% Rat Human +DTXSID50187178 Css NA 1.575 mg/L PBTK NA 95% Rat Human +DTXSID50188024 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50188024 Fup 0.0132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50188024 Vd NA 10.38 L/kg 1compartment NA NA Human Human +DTXSID50188024 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID50188024 TK.Half.Life NA 130.3 hours 1compartment NA NA Human Human +DTXSID50188024 Css NA 1.095 mg/L 3compartmentss NA 50% Human Human +DTXSID50188024 Css NA 12.1 mg/L 3compartmentss NA 95% Human Human +DTXSID50188024 Css NA 1.288 mg/L PBTK NA 50% Human Human +DTXSID50188024 Css NA 10.65 mg/L PBTK NA 95% Human Human +DTXSID50188024 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50188024 Fup 0.0132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50188024 Vd NA 8.204 L/kg 1compartment NA NA Rat Human +DTXSID50188024 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID50188024 TK.Half.Life NA 46.74 hours 1compartment NA NA Rat Human +DTXSID50188024 Css NA 0.1352 mg/L 3compartmentss NA 50% Rat Human +DTXSID50188024 Css NA 1.274 mg/L 3compartmentss NA 95% Rat Human +DTXSID50188024 Css NA 0.1609 mg/L PBTK NA 50% Rat Human +DTXSID50188024 Css NA 1.079 mg/L PBTK NA 95% Rat Human +DTXSID50189319 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50189319 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50189319 Vd NA 2.041 L/kg 1compartment NA NA Human Human +DTXSID50189319 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50189319 TK.Half.Life NA 4.281 hours 1compartment NA NA Human Human +DTXSID50189319 Css NA 0.126 mg/L 3compartmentss NA 50% Human Human +DTXSID50189319 Css NA 0.926 mg/L 3compartmentss NA 95% Human Human +DTXSID50189319 Css NA 0.1165 mg/L PBTK NA 50% Human Human +DTXSID50189319 Css NA 0.7187 mg/L PBTK NA 95% Human Human +DTXSID50189319 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50189319 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50189319 Vd NA 2.035 L/kg 1compartment NA NA Rat Human +DTXSID50189319 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50189319 TK.Half.Life NA 2.431 hours 1compartment NA NA Rat Human +DTXSID50189319 Css NA 0.005392 mg/L 3compartmentss NA 50% Rat Human +DTXSID50189319 Css NA 0.04573 mg/L 3compartmentss NA 95% Rat Human +DTXSID50189319 Css NA 0.005144 mg/L PBTK NA 50% Rat Human +DTXSID50189319 Css NA 0.03492 mg/L PBTK NA 95% Rat Human +DTXSID50196583 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50196583 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50196583 Vd NA 3.11 L/kg 1compartment NA NA Human Human +DTXSID50196583 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID50196583 TK.Half.Life NA 90.73 hours 1compartment NA NA Human Human +DTXSID50196583 Css NA 3.436 mg/L 3compartmentss NA 50% Human Human +DTXSID50196583 Css NA 20.75 mg/L 3compartmentss NA 95% Human Human +DTXSID50196583 Css NA 2.377 mg/L PBTK NA 50% Human Human +DTXSID50196583 Css NA 14.02 mg/L PBTK NA 95% Human Human +DTXSID50196583 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50196583 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50196583 Vd NA 2.33 L/kg 1compartment NA NA Rat Human +DTXSID50196583 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID50196583 TK.Half.Life NA 12.34 hours 1compartment NA NA Rat Human +DTXSID50196583 Css NA 0.4476 mg/L 3compartmentss NA 50% Rat Human +DTXSID50196583 Css NA 2.262 mg/L 3compartmentss NA 95% Rat Human +DTXSID50196583 Css NA 0.306 mg/L PBTK NA 50% Rat Human +DTXSID50196583 Css NA 1.547 mg/L PBTK NA 95% Rat Human +DTXSID50197398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50197398 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50197398 Vd NA 2.856 L/kg 1compartment NA NA Human Human +DTXSID50197398 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50197398 TK.Half.Life NA 3.391 hours 1compartment NA NA Human Human +DTXSID50197398 Css NA 0.05042 mg/L 3compartmentss NA 50% Human Human +DTXSID50197398 Css NA 0.4173 mg/L 3compartmentss NA 95% Human Human +DTXSID50197398 Css NA 0.04515 mg/L PBTK NA 50% Human Human +DTXSID50197398 Css NA 0.3224 mg/L PBTK NA 95% Human Human +DTXSID50197398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50197398 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50197398 Vd NA 2.428 L/kg 1compartment NA NA Rat Human +DTXSID50197398 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50197398 TK.Half.Life NA 1.203 hours 1compartment NA NA Rat Human +DTXSID50197398 Css NA 0.002401 mg/L 3compartmentss NA 50% Rat Human +DTXSID50197398 Css NA 0.02104 mg/L 3compartmentss NA 95% Rat Human +DTXSID50197398 Css NA 0.002156 mg/L PBTK NA 50% Rat Human +DTXSID50197398 Css NA 0.01611 mg/L PBTK NA 95% Rat Human +DTXSID50198249 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50198249 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50198249 Vd NA 0.7724 L/kg 1compartment NA NA Human Human +DTXSID50198249 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50198249 TK.Half.Life NA 3.169 hours 1compartment NA NA Human Human +DTXSID50198249 Css NA 0.3612 mg/L 3compartmentss NA 50% Human Human +DTXSID50198249 Css NA 2.344 mg/L 3compartmentss NA 95% Human Human +DTXSID50198249 Css NA 0.2488 mg/L PBTK NA 50% Human Human +DTXSID50198249 Css NA 1.514 mg/L PBTK NA 95% Human Human +DTXSID50198249 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50198249 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50198249 Vd NA 0.7699 L/kg 1compartment NA NA Rat Human +DTXSID50198249 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50198249 TK.Half.Life NA 1.886 hours 1compartment NA NA Rat Human +DTXSID50198249 Css NA 0.01294 mg/L 3compartmentss NA 50% Rat Human +DTXSID50198249 Css NA 0.09644 mg/L 3compartmentss NA 95% Rat Human +DTXSID50198249 Css NA 0.00866 mg/L PBTK NA 50% Rat Human +DTXSID50198249 Css NA 0.06089 mg/L PBTK NA 95% Rat Human +DTXSID5020021 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5020021 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5020021 Vd NA 0.2917 L/kg 1compartment NA NA Human Human +DTXSID5020021 Vd NA 0.3115 L/kg 1compartment NA NA Human Human DTXSID5020021 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5020021 TK.Half.Life NA 11.1 hours 1compartment NA NA Human Human -DTXSID5020021 Css NA 4.95 mg/L 3compartmentss NA 50% Human Human -DTXSID5020021 Css NA 18.4 mg/L 3compartmentss NA 95% Human Human -DTXSID5020021 Css NA 3.15 mg/L PBTK NA 50% Human Human -DTXSID5020021 Css NA 10.92 mg/L PBTK NA 95% Human Human -DTXSID5020021 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5020021 TK.Half.Life NA 11.86 hours 1compartment NA NA Human Human +DTXSID5020021 Css NA 4.171 mg/L 3compartmentss NA 50% Human Human +DTXSID5020021 Css NA 15.65 mg/L 3compartmentss NA 95% Human Human +DTXSID5020021 Css NA 2.673 mg/L PBTK NA 50% Human Human +DTXSID5020021 Css NA 9.359 mg/L PBTK NA 95% Human Human +DTXSID5020021 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5020021 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5020021 Vd NA 0.304 L/kg 1compartment NA NA Rat Human +DTXSID5020021 Vd NA 0.321 L/kg 1compartment NA NA Rat Human DTXSID5020021 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020021 TK.Half.Life NA 3.943 hours 1compartment NA NA Rat Human -DTXSID5020021 Css NA 1.388 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020021 Css NA 4.187 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020021 Css NA 0.8284 mg/L PBTK NA 50% Rat Human -DTXSID5020021 Css NA 2.345 mg/L PBTK NA 95% Rat Human +DTXSID5020021 TK.Half.Life NA 4.163 hours 1compartment NA NA Rat Human +DTXSID5020021 Css NA 0.07542 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020021 Css NA 0.4215 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020021 Css NA 0.0459 mg/L PBTK NA 50% Rat Human +DTXSID5020021 Css NA 0.2492 mg/L PBTK NA 95% Rat Human DTXSID5020027 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020027 Fup NA 0.8996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020027 Vd NA 0.7709 L/kg 1compartment NA NA Human Human DTXSID5020027 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5020027 TK.Half.Life NA 5.554 hours 1compartment NA NA Human Human -DTXSID5020027 Css NA 0.9395 mg/L 3compartmentss NA 50% Human Human -DTXSID5020027 Css NA 3.563 mg/L 3compartmentss NA 95% Human Human -DTXSID5020027 Css NA 0.7345 mg/L PBTK NA 50% Human Human -DTXSID5020027 Css NA 2.389 mg/L PBTK NA 95% Human Human +DTXSID5020027 Css NA 0.8738 mg/L 3compartmentss NA 50% Human Human +DTXSID5020027 Css NA 2.869 mg/L 3compartmentss NA 95% Human Human +DTXSID5020027 Css NA 0.7199 mg/L PBTK NA 50% Human Human +DTXSID5020027 Css NA 2.363 mg/L PBTK NA 95% Human Human DTXSID5020027 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020027 Fup NA 0.8996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020027 Vd NA 0.7995 L/kg 1compartment NA NA Rat Human DTXSID5020027 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020027 TK.Half.Life NA 1.96 hours 1compartment NA NA Rat Human -DTXSID5020027 Css NA 0.2446 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020027 Css NA 0.8708 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020027 Css NA 0.1856 mg/L PBTK NA 50% Rat Human -DTXSID5020027 Css NA 0.5361 mg/L PBTK NA 95% Rat Human -DTXSID5020071 Clint NA 10.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020071 Fup NA 0.0934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020071 Vd NA 1.651 L/kg 1compartment NA NA Human Human +DTXSID5020027 Css NA 0.05082 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020027 Css NA 0.1426 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020027 Css NA 0.04336 mg/L PBTK NA 50% Rat Human +DTXSID5020027 Css NA 0.1217 mg/L PBTK NA 95% Rat Human +DTXSID50200412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50200412 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50200412 Vd NA 0.6423 L/kg 1compartment NA NA Human Human +DTXSID50200412 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50200412 TK.Half.Life NA 7.119 hours 1compartment NA NA Human Human +DTXSID50200412 Css NA 1.264 mg/L 3compartmentss NA 50% Human Human +DTXSID50200412 Css NA 8.674 mg/L 3compartmentss NA 95% Human Human +DTXSID50200412 Css NA 0.9856 mg/L PBTK NA 50% Human Human +DTXSID50200412 Css NA 5.389 mg/L PBTK NA 95% Human Human +DTXSID50200412 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50200412 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50200412 Vd NA 0.6569 L/kg 1compartment NA NA Rat Human +DTXSID50200412 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50200412 TK.Half.Life NA 2.477 hours 1compartment NA NA Rat Human +DTXSID50200412 Css NA 0.07593 mg/L 3compartmentss NA 50% Rat Human +DTXSID50200412 Css NA 0.4829 mg/L 3compartmentss NA 95% Rat Human +DTXSID50200412 Css NA 0.05914 mg/L PBTK NA 50% Rat Human +DTXSID50200412 Css NA 0.2917 mg/L PBTK NA 95% Rat Human +DTXSID5020071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020071 Fup 0.0882 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020071 Vd NA 1.611 L/kg 1compartment NA NA Human Human DTXSID5020071 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020071 TK.Half.Life NA 8.933 hours 1compartment NA NA Human Human -DTXSID5020071 Css NA 0.7158 mg/L 3compartmentss NA 50% Human Human -DTXSID5020071 Css NA 4.993 mg/L 3compartmentss NA 95% Human Human -DTXSID5020071 Css NA 0.4742 mg/L PBTK NA 50% Human Human -DTXSID5020071 Css NA 3.133 mg/L PBTK NA 95% Human Human -DTXSID5020071 Clint NA 10.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020071 Fup NA 0.0934 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020071 Vd NA 1.256 L/kg 1compartment NA NA Rat Human +DTXSID5020071 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human +DTXSID5020071 Css NA 0.3591 mg/L 3compartmentss NA 50% Human Human +DTXSID5020071 Css NA 2.641 mg/L 3compartmentss NA 95% Human Human +DTXSID5020071 Css NA 0.2373 mg/L PBTK NA 50% Human Human +DTXSID5020071 Css NA 1.66 mg/L PBTK NA 95% Human Human +DTXSID5020071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020071 Fup 0.0882 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020071 Vd NA 1.225 L/kg 1compartment NA NA Rat Human DTXSID5020071 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020071 TK.Half.Life NA 3.309 hours 1compartment NA NA Rat Human -DTXSID5020071 Css NA 0.3887 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020071 Css NA 1.945 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020071 Css NA 0.2438 mg/L PBTK NA 50% Rat Human -DTXSID5020071 Css NA 1.161 mg/L PBTK NA 95% Rat Human +DTXSID5020071 TK.Half.Life NA 1.931 hours 1compartment NA NA Rat Human +DTXSID5020071 Css NA 0.04651 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020071 Css NA 0.2713 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020071 Css NA 0.0301 mg/L PBTK NA 50% Rat Human +DTXSID5020071 Css NA 0.1689 mg/L PBTK NA 95% Rat Human DTXSID5020079 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020079 Fup NA 0.8331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020079 Vd NA 0.6486 L/kg 1compartment NA NA Human Human +DTXSID5020079 Vd NA 0.6429 L/kg 1compartment NA NA Human Human DTXSID5020079 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020079 TK.Half.Life NA 5.037 hours 1compartment NA NA Human Human -DTXSID5020079 Css NA 0.9942 mg/L 3compartmentss NA 50% Human Human -DTXSID5020079 Css NA 5.842 mg/L 3compartmentss NA 95% Human Human -DTXSID5020079 Css NA 0.7968 mg/L PBTK NA 50% Human Human -DTXSID5020079 Css NA 3.742 mg/L PBTK NA 95% Human Human +DTXSID5020079 TK.Half.Life NA 4.994 hours 1compartment NA NA Human Human +DTXSID5020079 Css NA 0.8402 mg/L 3compartmentss NA 50% Human Human +DTXSID5020079 Css NA 5.166 mg/L 3compartmentss NA 95% Human Human +DTXSID5020079 Css NA 0.6801 mg/L PBTK NA 50% Human Human +DTXSID5020079 Css NA 3.317 mg/L PBTK NA 95% Human Human DTXSID5020079 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020079 Fup NA 0.8331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020079 Vd NA 0.6897 L/kg 1compartment NA NA Rat Human +DTXSID5020079 Vd NA 0.685 L/kg 1compartment NA NA Rat Human DTXSID5020079 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020079 TK.Half.Life NA 1.826 hours 1compartment NA NA Rat Human -DTXSID5020079 Css NA 0.2544 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020079 Css NA 1.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020079 Css NA 0.1983 mg/L PBTK NA 50% Rat Human -DTXSID5020079 Css NA 0.8685 mg/L PBTK NA 95% Rat Human -DTXSID5020106 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5020079 TK.Half.Life NA 1.813 hours 1compartment NA NA Rat Human +DTXSID5020079 Css NA 0.01568 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020079 Css NA 0.1216 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020079 Css NA 0.01214 mg/L PBTK NA 50% Rat Human +DTXSID5020079 Css NA 0.07766 mg/L PBTK NA 95% Rat Human +DTXSID5020106 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5020106 Fup 0.26 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5020106 Vd NA 0.2589 L/kg 1compartment NA NA Human Human DTXSID5020106 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020106 TK.Half.Life NA 6.442 hours 1compartment NA NA Human Human -DTXSID5020106 Css NA 2.452 mg/L 3compartmentss NA 50% Human Human -DTXSID5020106 Css NA 10.38 mg/L 3compartmentss NA 95% Human Human -DTXSID5020106 Css NA 2.038 mg/L PBTK NA 50% Human Human -DTXSID5020106 Css NA 6.935 mg/L PBTK NA 95% Human Human -DTXSID5020106 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5020106 TK.Half.Life NA 0.3068 hours 1compartment NA NA Human Human +DTXSID5020106 Css NA 0.0469 mg/L 3compartmentss NA 50% Human Human +DTXSID5020106 Css NA 0.3599 mg/L 3compartmentss NA 95% Human Human +DTXSID5020106 Css NA 0.03829 mg/L PBTK NA 50% Human Human +DTXSID5020106 Css NA 0.2945 mg/L PBTK NA 95% Human Human +DTXSID5020106 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5020106 Fup 0.26 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5020106 Vd NA 0.2694 L/kg 1compartment NA NA Rat Human DTXSID5020106 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020106 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human -DTXSID5020106 Css NA 0.6735 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020106 Css NA 2.422 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020106 Css NA 0.5374 mg/L PBTK NA 50% Rat Human -DTXSID5020106 Css NA 1.527 mg/L PBTK NA 95% Rat Human +DTXSID5020106 TK.Half.Life NA 0.1731 hours 1compartment NA NA Rat Human +DTXSID5020106 Css NA 0.002152 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020106 Css NA 0.0175 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020106 Css NA 0.001794 mg/L PBTK NA 50% Rat Human +DTXSID5020106 Css NA 0.01476 mg/L PBTK NA 95% Rat Human DTXSID5020108 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020108 Fup 0.532 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020108 Vd NA 1.245 L/kg 1compartment NA NA Human Human DTXSID5020108 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID5020108 TK.Half.Life NA 15.14 hours 1compartment NA NA Human Human -DTXSID5020108 Css NA 0.08003 mg/L 3compartmentss NA 50% Human Human -DTXSID5020108 Css NA 0.5535 mg/L 3compartmentss NA 95% Human Human -DTXSID5020108 Css NA 0.06465 mg/L PBTK NA 50% Human Human -DTXSID5020108 Css NA 0.3966 mg/L PBTK NA 95% Human Human +DTXSID5020108 Css NA 0.07632 mg/L 3compartmentss NA 50% Human Human +DTXSID5020108 Css NA 0.4716 mg/L 3compartmentss NA 95% Human Human +DTXSID5020108 Css NA 0.06172 mg/L PBTK NA 50% Human Human +DTXSID5020108 Css NA 0.3823 mg/L PBTK NA 95% Human Human DTXSID5020108 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020108 Fup 0.532 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020108 Vd NA 1.234 L/kg 1compartment NA NA Rat Human DTXSID5020108 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020108 TK.Half.Life NA 5.115 hours 1compartment NA NA Rat Human -DTXSID5020108 Css NA 0.04069 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020108 Css NA 0.2097 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020108 Css NA 0.03245 mg/L PBTK NA 50% Rat Human -DTXSID5020108 Css NA 0.1429 mg/L PBTK NA 95% Rat Human -DTXSID5020152 Clint NA 1.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020152 Fup NA 0.7253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020152 Vd NA 1.195 L/kg 1compartment NA NA Human Human +DTXSID5020108 Css NA 0.008553 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020108 Css NA 0.03866 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020108 Css NA 0.007212 mg/L PBTK NA 50% Rat Human +DTXSID5020108 Css NA 0.03257 mg/L PBTK NA 95% Rat Human +DTXSID5020152 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020152 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020152 Vd NA 0.8743 L/kg 1compartment NA NA Human Human DTXSID5020152 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020152 TK.Half.Life NA 3.506 hours 1compartment NA NA Human Human -DTXSID5020152 Css NA 0.2926 mg/L 3compartmentss NA 50% Human Human -DTXSID5020152 Css NA 1.98 mg/L 3compartmentss NA 95% Human Human -DTXSID5020152 Css NA 0.2582 mg/L PBTK NA 50% Human Human -DTXSID5020152 Css NA 1.351 mg/L PBTK NA 95% Human Human -DTXSID5020152 Clint NA 1.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020152 Fup NA 0.7253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020152 Vd NA 1.105 L/kg 1compartment NA NA Rat Human +DTXSID5020152 TK.Half.Life NA 0.9382 hours 1compartment NA NA Human Human +DTXSID5020152 Css NA 0.04462 mg/L 3compartmentss NA 50% Human Human +DTXSID5020152 Css NA 0.3679 mg/L 3compartmentss NA 95% Human Human +DTXSID5020152 Css NA 0.03438 mg/L PBTK NA 50% Human Human +DTXSID5020152 Css NA 0.2572 mg/L PBTK NA 95% Human Human +DTXSID5020152 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020152 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020152 Vd NA 0.804 L/kg 1compartment NA NA Rat Human DTXSID5020152 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020152 TK.Half.Life NA 1.591 hours 1compartment NA NA Rat Human -DTXSID5020152 Css NA 0.1185 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020152 Css NA 0.8078 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020152 Css NA 0.1021 mg/L PBTK NA 50% Rat Human -DTXSID5020152 Css NA 0.4961 mg/L PBTK NA 95% Rat Human -DTXSID5020156 Clint NA 2.209 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020156 Fup NA 0.4359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020156 Vd NA 1.633 L/kg 1compartment NA NA Human Human +DTXSID5020152 TK.Half.Life NA 0.4387 hours 1compartment NA NA Rat Human +DTXSID5020152 Css NA 0.00555 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020152 Css NA 0.03588 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020152 Css NA 0.00434 mg/L PBTK NA 50% Rat Human +DTXSID5020152 Css NA 0.02479 mg/L PBTK NA 95% Rat Human +DTXSID5020156 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020156 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020156 Vd NA 1.005 L/kg 1compartment NA NA Human Human DTXSID5020156 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020156 TK.Half.Life NA 7.141 hours 1compartment NA NA Human Human -DTXSID5020156 Css NA 0.4256 mg/L 3compartmentss NA 50% Human Human -DTXSID5020156 Css NA 2.257 mg/L 3compartmentss NA 95% Human Human -DTXSID5020156 Css NA 0.3462 mg/L PBTK NA 50% Human Human -DTXSID5020156 Css NA 1.571 mg/L PBTK NA 95% Human Human -DTXSID5020156 Clint NA 2.209 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020156 Fup NA 0.4359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020156 Vd NA 1.345 L/kg 1compartment NA NA Rat Human +DTXSID5020156 TK.Half.Life NA 1.858 hours 1compartment NA NA Human Human +DTXSID5020156 Css NA 0.1337 mg/L 3compartmentss NA 50% Human Human +DTXSID5020156 Css NA 0.9311 mg/L 3compartmentss NA 95% Human Human +DTXSID5020156 Css NA 0.09176 mg/L PBTK NA 50% Human Human +DTXSID5020156 Css NA 0.6102 mg/L PBTK NA 95% Human Human +DTXSID5020156 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020156 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020156 Vd NA 0.8186 L/kg 1compartment NA NA Rat Human DTXSID5020156 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020156 TK.Half.Life NA 2.682 hours 1compartment NA NA Rat Human -DTXSID5020156 Css NA 0.1896 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020156 Css NA 0.8092 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020156 Css NA 0.1508 mg/L PBTK NA 50% Rat Human -DTXSID5020156 Css NA 0.5178 mg/L PBTK NA 95% Rat Human -DTXSID5020231 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020231 Fup NA 0.1684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020231 Vd NA 0.3167 L/kg 1compartment NA NA Human Human -DTXSID5020231 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5020231 TK.Half.Life NA 12.17 hours 1compartment NA NA Human Human -DTXSID5020231 Css NA 4.784 mg/L 3compartmentss NA 50% Human Human -DTXSID5020231 Css NA 17.39 mg/L 3compartmentss NA 95% Human Human -DTXSID5020231 Css NA 3.1 mg/L PBTK NA 50% Human Human -DTXSID5020231 Css NA 10.48 mg/L PBTK NA 95% Human Human -DTXSID5020231 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020231 Fup NA 0.1684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020231 Vd NA 0.3171 L/kg 1compartment NA NA Rat Human +DTXSID5020156 TK.Half.Life NA 0.8145 hours 1compartment NA NA Rat Human +DTXSID5020156 Css NA 0.01724 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020156 Css NA 0.09171 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020156 Css NA 0.01168 mg/L PBTK NA 50% Rat Human +DTXSID5020156 Css NA 0.0589 mg/L PBTK NA 95% Rat Human +DTXSID5020231 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020231 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020231 Vd NA 0.4403 L/kg 1compartment NA NA Human Human +DTXSID5020231 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5020231 TK.Half.Life NA 8.329 hours 1compartment NA NA Human Human +DTXSID5020231 Css NA 1.16 mg/L 3compartmentss NA 50% Human Human +DTXSID5020231 Css NA 5.111 mg/L 3compartmentss NA 95% Human Human +DTXSID5020231 Css NA 0.8352 mg/L PBTK NA 50% Human Human +DTXSID5020231 Css NA 3.228 mg/L PBTK NA 95% Human Human +DTXSID5020231 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020231 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020231 Vd NA 0.4433 L/kg 1compartment NA NA Rat Human DTXSID5020231 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020231 TK.Half.Life NA 4.151 hours 1compartment NA NA Rat Human -DTXSID5020231 Css NA 1.344 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020231 Css NA 3.953 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020231 Css NA 0.8176 mg/L PBTK NA 50% Rat Human -DTXSID5020231 Css NA 2.234 mg/L PBTK NA 95% Rat Human -DTXSID5020233 Clint NA 127.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020233 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020233 Vd NA 203 L/kg 1compartment NA NA Human Human -DTXSID5020233 Days.Css NA 248 Days PBTK NA NA Human Human -DTXSID5020233 TK.Half.Life NA 1030 hours 1compartment NA NA Human Human -DTXSID5020233 Css NA 0.01557 mg/L 3compartmentss NA 50% Human Human -DTXSID5020233 Css NA 0.09173 mg/L 3compartmentss NA 95% Human Human -DTXSID5020233 Css NA 0.4194 mg/L PBTK NA 50% Human Human -DTXSID5020233 Css NA 2.28 mg/L PBTK NA 95% Human Human -DTXSID5020233 Clint NA 127.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020233 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020233 Vd NA 179.5 L/kg 1compartment NA NA Rat Human -DTXSID5020233 Days.Css NA 166 Days PBTK NA NA Rat Human -DTXSID5020233 TK.Half.Life NA 162.6 hours 1compartment NA NA Rat Human -DTXSID5020233 Css NA 0.007916 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020233 Css NA 0.03468 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020233 Css NA 0.2278 mg/L PBTK NA 50% Rat Human -DTXSID5020233 Css NA 0.992 mg/L PBTK NA 95% Rat Human -DTXSID5020235 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020235 Fup NA 0.2392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020235 Vd NA 0.3121 L/kg 1compartment NA NA Human Human -DTXSID5020235 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020235 TK.Half.Life NA 8.441 hours 1compartment NA NA Human Human -DTXSID5020235 Css NA 3.392 mg/L 3compartmentss NA 50% Human Human -DTXSID5020235 Css NA 12.21 mg/L 3compartmentss NA 95% Human Human -DTXSID5020235 Css NA 2.212 mg/L PBTK NA 50% Human Human -DTXSID5020235 Css NA 7.415 mg/L PBTK NA 95% Human Human -DTXSID5020235 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020235 Fup NA 0.2392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020235 Vd NA 0.3339 L/kg 1compartment NA NA Rat Human -DTXSID5020235 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020235 TK.Half.Life NA 3.078 hours 1compartment NA NA Rat Human -DTXSID5020235 Css NA 0.9422 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020235 Css NA 2.859 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020235 Css NA 0.58 mg/L PBTK NA 50% Rat Human -DTXSID5020235 Css NA 1.621 mg/L PBTK NA 95% Rat Human -DTXSID5020239 Clint NA 51.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020239 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020239 Vd NA 1.045 L/kg 1compartment NA NA Human Human -DTXSID5020239 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020239 TK.Half.Life NA 10.28 hours 1compartment NA NA Human Human -DTXSID5020239 Css NA 1.658 mg/L 3compartmentss NA 50% Human Human -DTXSID5020239 Css NA 16.23 mg/L 3compartmentss NA 95% Human Human -DTXSID5020239 Css NA 1.002 mg/L PBTK NA 50% Human Human -DTXSID5020239 Css NA 9.589 mg/L PBTK NA 95% Human Human -DTXSID5020239 Clint NA 51.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020239 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020239 Vd NA 0.7663 L/kg 1compartment NA NA Rat Human +DTXSID5020231 TK.Half.Life NA 2.858 hours 1compartment NA NA Rat Human +DTXSID5020231 Css NA 0.006282 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020231 Css NA 0.02763 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020231 Css NA 0.004292 mg/L PBTK NA 50% Rat Human +DTXSID5020231 Css NA 0.01681 mg/L PBTK NA 95% Rat Human +DTXSID5020233 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020233 Fup 0.0454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020233 Vd NA 15980 L/kg 1compartment NA NA Human Human +DTXSID5020233 Days.Css NA 8526 Days PBTK NA NA Human Human +DTXSID5020233 TK.Half.Life NA 467100 hours 1compartment NA NA Human Human +DTXSID5020233 Css NA 0.0004232 mg/L 3compartmentss NA 50% Human Human +DTXSID5020233 Css NA 0.002836 mg/L 3compartmentss NA 95% Human Human +DTXSID5020233 Css NA 1.286 mg/L PBTK NA 50% Human Human +DTXSID5020233 Css NA 7.592 mg/L PBTK NA 95% Human Human +DTXSID5020233 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020233 Fup 0.0454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020233 Vd NA 15090 L/kg 1compartment NA NA Rat Human +DTXSID5020233 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID5020233 TK.Half.Life NA 74500 hours 1compartment NA NA Rat Human +DTXSID5020233 Css NA 4.09e-06 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020233 Css NA 2.527e-05 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020233 Css NA 0.0135 mg/L PBTK NA 50% Rat Human +DTXSID5020233 Css NA 0.08094 mg/L PBTK NA 95% Rat Human +DTXSID5020239 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020239 Fup 0.027 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020239 Vd NA 1.856 L/kg 1compartment NA NA Human Human +DTXSID5020239 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5020239 TK.Half.Life NA 14.53 hours 1compartment NA NA Human Human +DTXSID5020239 Css NA 1.137 mg/L 3compartmentss NA 50% Human Human +DTXSID5020239 Css NA 10.4 mg/L 3compartmentss NA 95% Human Human +DTXSID5020239 Css NA 0.7323 mg/L PBTK NA 50% Human Human +DTXSID5020239 Css NA 6.33 mg/L PBTK NA 95% Human Human +DTXSID5020239 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020239 Fup 0.027 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020239 Vd NA 1.407 L/kg 1compartment NA NA Rat Human DTXSID5020239 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020239 TK.Half.Life NA 4.449 hours 1compartment NA NA Rat Human -DTXSID5020239 Css NA 0.9488 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020239 Css NA 7.781 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020239 Css NA 0.5344 mg/L PBTK NA 50% Rat Human -DTXSID5020239 Css NA 4.282 mg/L PBTK NA 95% Rat Human +DTXSID5020239 TK.Half.Life NA 5.204 hours 1compartment NA NA Rat Human +DTXSID5020239 Css NA 0.1476 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020239 Css NA 1.012 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020239 Css NA 0.09294 mg/L PBTK NA 50% Rat Human +DTXSID5020239 Css NA 0.6046 mg/L PBTK NA 95% Rat Human DTXSID5020281 Clint 400 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020281 Fup NA 0.251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020281 Vd NA 1.715 L/kg 1compartment NA NA Human Human DTXSID5020281 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5020281 TK.Half.Life NA 1.359 hours 1compartment NA NA Human Human -DTXSID5020281 Css NA 0.006224 mg/L 3compartmentss NA 50% Human Human -DTXSID5020281 Css NA 0.05458 mg/L 3compartmentss NA 95% Human Human -DTXSID5020281 Css NA 0.004576 mg/L PBTK NA 50% Human Human -DTXSID5020281 Css NA 0.03796 mg/L PBTK NA 95% Human Human +DTXSID5020281 Css NA 0.003686 mg/L 3compartmentss NA 50% Human Human +DTXSID5020281 Css NA 0.04776 mg/L 3compartmentss NA 95% Human Human +DTXSID5020281 Css NA 0.002716 mg/L PBTK NA 50% Human Human +DTXSID5020281 Css NA 0.03311 mg/L PBTK NA 95% Human Human DTXSID5020281 Clint 400 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020281 Fup NA 0.251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020281 Vd NA 0.9738 L/kg 1compartment NA NA Rat Human DTXSID5020281 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020281 TK.Half.Life NA 0.4101 hours 1compartment NA NA Rat Human -DTXSID5020281 Css NA 0.00756 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020281 Css NA 0.06122 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020281 Css NA 0.004818 mg/L PBTK NA 50% Rat Human -DTXSID5020281 Css NA 0.03656 mg/L PBTK NA 95% Rat Human +DTXSID5020281 Css NA 0.0008115 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020281 Css NA 0.01014 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020281 Css NA 0.0005324 mg/L PBTK NA 50% Rat Human +DTXSID5020281 Css NA 0.006204 mg/L PBTK NA 95% Rat Human DTXSID5020283 Clint 31.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020283 Fup 0.373 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5020283 Vd NA 0.9031 L/kg 1compartment NA NA Human Human +DTXSID5020283 Vd NA 0.8975 L/kg 1compartment NA NA Human Human DTXSID5020283 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020283 TK.Half.Life NA 0.9186 hours 1compartment NA NA Human Human -DTXSID5020283 Css NA 0.03615 mg/L 3compartmentss NA 50% Human Human -DTXSID5020283 Css NA 0.2353 mg/L 3compartmentss NA 95% Human Human -DTXSID5020283 Css NA 0.02758 mg/L PBTK NA 50% Human Human -DTXSID5020283 Css NA 0.167 mg/L PBTK NA 95% Human Human +DTXSID5020283 TK.Half.Life NA 0.913 hours 1compartment NA NA Human Human +DTXSID5020283 Css NA 0.03294 mg/L 3compartmentss NA 50% Human Human +DTXSID5020283 Css NA 0.2308 mg/L 3compartmentss NA 95% Human Human +DTXSID5020283 Css NA 0.02506 mg/L PBTK NA 50% Human Human +DTXSID5020283 Css NA 0.1648 mg/L PBTK NA 95% Human Human DTXSID5020283 Clint 31.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020283 Fup 0.373 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5020283 Vd NA 0.811 L/kg 1compartment NA NA Rat Human +DTXSID5020283 Vd NA 0.8073 L/kg 1compartment NA NA Rat Human DTXSID5020283 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020283 TK.Half.Life NA 0.4106 hours 1compartment NA NA Rat Human -DTXSID5020283 Css NA 0.01932 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020283 Css NA 0.09655 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020283 Css NA 0.0143 mg/L PBTK NA 50% Rat Human -DTXSID5020283 Css NA 0.06616 mg/L PBTK NA 95% Rat Human -DTXSID5020287 Clint NA 3.589 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020287 Fup NA 0.261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020287 Vd NA 1.314 L/kg 1compartment NA NA Human Human +DTXSID5020283 TK.Half.Life NA 0.4087 hours 1compartment NA NA Rat Human +DTXSID5020283 Css NA 0.004226 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020283 Css NA 0.0214 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020283 Css NA 0.003206 mg/L PBTK NA 50% Rat Human +DTXSID5020283 Css NA 0.01582 mg/L PBTK NA 95% Rat Human +DTXSID5020287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020287 Fup 0.0718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020287 Vd NA 0.8598 L/kg 1compartment NA NA Human Human DTXSID5020287 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020287 TK.Half.Life NA 6.054 hours 1compartment NA NA Human Human -DTXSID5020287 Css NA 0.474 mg/L 3compartmentss NA 50% Human Human -DTXSID5020287 Css NA 2.526 mg/L 3compartmentss NA 95% Human Human -DTXSID5020287 Css NA 0.35 mg/L PBTK NA 50% Human Human -DTXSID5020287 Css NA 1.682 mg/L PBTK NA 95% Human Human -DTXSID5020287 Clint NA 3.589 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020287 Fup NA 0.261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020287 Vd NA 1.07 L/kg 1compartment NA NA Rat Human +DTXSID5020287 TK.Half.Life NA 2.825 hours 1compartment NA NA Human Human +DTXSID5020287 Css NA 0.3948 mg/L 3compartmentss NA 50% Human Human +DTXSID5020287 Css NA 2.927 mg/L 3compartmentss NA 95% Human Human +DTXSID5020287 Css NA 0.2488 mg/L PBTK NA 50% Human Human +DTXSID5020287 Css NA 1.794 mg/L PBTK NA 95% Human Human +DTXSID5020287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020287 Fup 0.0718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020287 Vd NA 0.6749 L/kg 1compartment NA NA Rat Human DTXSID5020287 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020287 TK.Half.Life NA 2.508 hours 1compartment NA NA Rat Human -DTXSID5020287 Css NA 0.2327 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020287 Css NA 0.8945 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020287 Css NA 0.1643 mg/L PBTK NA 50% Rat Human -DTXSID5020287 Css NA 0.5573 mg/L PBTK NA 95% Rat Human -DTXSID5020312 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020312 Fup NA 0.0117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020312 Vd NA 6.638 L/kg 1compartment NA NA Human Human -DTXSID5020312 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID5020312 TK.Half.Life NA 74.24 hours 1compartment NA NA Human Human -DTXSID5020312 Css NA 0.9474 mg/L 3compartmentss NA 50% Human Human -DTXSID5020312 Css NA 5.589 mg/L 3compartmentss NA 95% Human Human -DTXSID5020312 Css NA 0.8788 mg/L PBTK NA 50% Human Human -DTXSID5020312 Css NA 5.028 mg/L PBTK NA 95% Human Human -DTXSID5020312 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020312 Fup NA 0.0117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020312 Vd NA 5.132 L/kg 1compartment NA NA Rat Human -DTXSID5020312 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID5020312 TK.Half.Life NA 10.79 hours 1compartment NA NA Rat Human -DTXSID5020312 Css NA 0.5266 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020312 Css NA 2.293 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020312 Css NA 0.4774 mg/L PBTK NA 50% Rat Human -DTXSID5020312 Css NA 2.107 mg/L PBTK NA 95% Rat Human -DTXSID5020360 Clint NA 17.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020360 Fup NA 0.0445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020360 Vd NA 1.371 L/kg 1compartment NA NA Human Human +DTXSID5020287 TK.Half.Life NA 1.281 hours 1compartment NA NA Rat Human +DTXSID5020287 Css NA 0.05137 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020287 Css NA 0.3033 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020287 Css NA 0.03146 mg/L PBTK NA 50% Rat Human +DTXSID5020287 Css NA 0.1801 mg/L PBTK NA 95% Rat Human +DTXSID5020310 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020310 Fup 0.00785 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020310 Vd NA 1.993 L/kg 1compartment NA NA Human Human +DTXSID5020310 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5020310 TK.Half.Life NA 35.75 hours 1compartment NA NA Human Human +DTXSID5020310 Css NA 2.764 mg/L 3compartmentss NA 50% Human Human +DTXSID5020310 Css NA 23.45 mg/L 3compartmentss NA 95% Human Human +DTXSID5020310 Css NA 1.764 mg/L PBTK NA 50% Human Human +DTXSID5020310 Css NA 14.36 mg/L PBTK NA 95% Human Human +DTXSID5020310 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020310 Fup 0.00785 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020310 Vd NA 1.476 L/kg 1compartment NA NA Rat Human +DTXSID5020310 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5020310 TK.Half.Life NA 11.47 hours 1compartment NA NA Rat Human +DTXSID5020310 Css NA 0.3613 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020310 Css NA 2.482 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020310 Css NA 0.2248 mg/L PBTK NA 50% Rat Human +DTXSID5020310 Css NA 1.468 mg/L PBTK NA 95% Rat Human +DTXSID5020312 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020312 Fup 0.00858 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020312 Vd NA 5.453 L/kg 1compartment NA NA Human Human +DTXSID5020312 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID5020312 TK.Half.Life NA 165.2 hours 1compartment NA NA Human Human +DTXSID5020312 Css NA 2.537 mg/L 3compartmentss NA 50% Human Human +DTXSID5020312 Css NA 14.53 mg/L 3compartmentss NA 95% Human Human +DTXSID5020312 Css NA 2.117 mg/L PBTK NA 50% Human Human +DTXSID5020312 Css NA 11.89 mg/L PBTK NA 95% Human Human +DTXSID5020312 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020312 Fup 0.00858 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020312 Vd NA 4.179 L/kg 1compartment NA NA Rat Human +DTXSID5020312 Days.Css NA 18 Days PBTK NA NA Rat Human +DTXSID5020312 TK.Half.Life NA 22.95 hours 1compartment NA NA Rat Human +DTXSID5020312 Css NA 0.1252 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020312 Css NA 0.7603 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020312 Css NA 0.1069 mg/L PBTK NA 50% Rat Human +DTXSID5020312 Css NA 0.6156 mg/L PBTK NA 95% Rat Human +DTXSID5020360 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020360 Fup 0.0288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020360 Vd NA 1.74 L/kg 1compartment NA NA Human Human DTXSID5020360 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020360 TK.Half.Life NA 4.234 hours 1compartment NA NA Human Human -DTXSID5020360 Css NA 0.3664 mg/L 3compartmentss NA 50% Human Human -DTXSID5020360 Css NA 3.417 mg/L 3compartmentss NA 95% Human Human -DTXSID5020360 Css NA 0.2664 mg/L PBTK NA 50% Human Human -DTXSID5020360 Css NA 2.192 mg/L PBTK NA 95% Human Human -DTXSID5020360 Clint NA 17.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020360 Fup NA 0.0445 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020360 Vd NA 1.336 L/kg 1compartment NA NA Rat Human +DTXSID5020360 TK.Half.Life NA 2.858 hours 1compartment NA NA Human Human +DTXSID5020360 Css NA 0.1333 mg/L 3compartmentss NA 50% Human Human +DTXSID5020360 Css NA 1.661 mg/L 3compartmentss NA 95% Human Human +DTXSID5020360 Css NA 0.1006 mg/L PBTK NA 50% Human Human +DTXSID5020360 Css NA 1.072 mg/L PBTK NA 95% Human Human +DTXSID5020360 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020360 Fup 0.0288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020360 Vd NA 1.652 L/kg 1compartment NA NA Rat Human DTXSID5020360 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020360 TK.Half.Life NA 2.575 hours 1compartment NA NA Rat Human -DTXSID5020360 Css NA 0.2071 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020360 Css NA 1.548 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020360 Css NA 0.1427 mg/L PBTK NA 50% Rat Human -DTXSID5020360 Css NA 0.9331 mg/L PBTK NA 95% Rat Human +DTXSID5020360 TK.Half.Life NA 1.541 hours 1compartment NA NA Rat Human +DTXSID5020360 Css NA 0.01786 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020360 Css NA 0.1826 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020360 Css NA 0.01332 mg/L PBTK NA 50% Rat Human +DTXSID5020360 Css NA 0.1171 mg/L PBTK NA 95% Rat Human +DTXSID5020364 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020364 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5020364 Vd NA 0.8821 L/kg 1compartment NA NA Human Human +DTXSID5020364 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5020364 TK.Half.Life NA 6.665 hours 1compartment NA NA Human Human +DTXSID5020364 Css NA 0.7162 mg/L 3compartmentss NA 50% Human Human +DTXSID5020364 Css NA 3.296 mg/L 3compartmentss NA 95% Human Human +DTXSID5020364 Css NA 0.7592 mg/L PBTK NA 50% Human Human +DTXSID5020364 Css NA 3.494 mg/L PBTK NA 95% Human Human +DTXSID5020364 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020364 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5020364 Vd NA 0.8649 L/kg 1compartment NA NA Rat Human +DTXSID5020364 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5020364 TK.Half.Life NA 2.201 hours 1compartment NA NA Rat Human +DTXSID5020364 Css NA 0.04154 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020364 Css NA 0.1731 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020364 Css NA 0.0456 mg/L PBTK NA 50% Rat Human +DTXSID5020364 Css NA 0.1898 mg/L PBTK NA 95% Rat Human DTXSID5020366 Clint 4.46 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020366 Fup 0.0584 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5020366 Vd NA 2.116 L/kg 1compartment NA NA Human Human -DTXSID5020366 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5020366 TK.Half.Life NA 42.76 hours 1compartment NA NA Human Human -DTXSID5020366 Css NA 2.464 mg/L 3compartmentss NA 50% Human Human -DTXSID5020366 Css NA 13.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5020366 Css NA 1.665 mg/L PBTK NA 50% Human Human -DTXSID5020366 Css NA 8.534 mg/L PBTK NA 95% Human Human +DTXSID5020366 Vd NA 2.291 L/kg 1compartment NA NA Human Human +DTXSID5020366 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID5020366 TK.Half.Life NA 51.5 hours 1compartment NA NA Human Human +DTXSID5020366 Css NA 2.689 mg/L 3compartmentss NA 50% Human Human +DTXSID5020366 Css NA 14.09 mg/L 3compartmentss NA 95% Human Human +DTXSID5020366 Css NA 1.817 mg/L PBTK NA 50% Human Human +DTXSID5020366 Css NA 9.135 mg/L PBTK NA 95% Human Human DTXSID5020366 Clint 4.46 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020366 Fup 0.0584 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5020366 Vd NA 1.588 L/kg 1compartment NA NA Rat Human -DTXSID5020366 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5020366 TK.Half.Life NA 12.43 hours 1compartment NA NA Rat Human -DTXSID5020366 Css NA 1.28 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020366 Css NA 4.685 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020366 Css NA 0.8234 mg/L PBTK NA 50% Rat Human -DTXSID5020366 Css NA 2.849 mg/L PBTK NA 95% Rat Human -DTXSID5020368 Clint NA 5.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020368 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020368 Vd NA 0.3538 L/kg 1compartment NA NA Human Human +DTXSID5020366 Vd NA 1.718 L/kg 1compartment NA NA Rat Human +DTXSID5020366 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5020366 TK.Half.Life NA 13.67 hours 1compartment NA NA Rat Human +DTXSID5020366 Css NA 0.3143 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020366 Css NA 1.157 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020366 Css NA 0.2112 mg/L PBTK NA 50% Rat Human +DTXSID5020366 Css NA 0.7512 mg/L PBTK NA 95% Rat Human +DTXSID5020368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020368 Fup 0.0935 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020368 Vd NA 0.3816 L/kg 1compartment NA NA Human Human DTXSID5020368 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020368 TK.Half.Life NA 3.577 hours 1compartment NA NA Human Human -DTXSID5020368 Css NA 1.621 mg/L 3compartmentss NA 50% Human Human -DTXSID5020368 Css NA 11.13 mg/L 3compartmentss NA 95% Human Human -DTXSID5020368 Css NA 1.011 mg/L PBTK NA 50% Human Human -DTXSID5020368 Css NA 6.682 mg/L PBTK NA 95% Human Human -DTXSID5020368 Clint NA 5.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020368 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020368 Vd NA 0.3471 L/kg 1compartment NA NA Rat Human +DTXSID5020368 TK.Half.Life NA 2.606 hours 1compartment NA NA Human Human +DTXSID5020368 Css NA 0.9739 mg/L 3compartmentss NA 50% Human Human +DTXSID5020368 Css NA 6.944 mg/L 3compartmentss NA 95% Human Human +DTXSID5020368 Css NA 0.6206 mg/L PBTK NA 50% Human Human +DTXSID5020368 Css NA 4.206 mg/L PBTK NA 95% Human Human +DTXSID5020368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020368 Fup 0.0935 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020368 Vd NA 0.3768 L/kg 1compartment NA NA Rat Human DTXSID5020368 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020368 TK.Half.Life NA 2.174 hours 1compartment NA NA Rat Human -DTXSID5020368 Css NA 0.856 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020368 Css NA 4.161 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020368 Css NA 0.5017 mg/L PBTK NA 50% Rat Human -DTXSID5020368 Css NA 2.324 mg/L PBTK NA 95% Rat Human -DTXSID5020441 Clint NA 3.924 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020441 Fup NA 0.0229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020441 Vd NA 0.2423 L/kg 1compartment NA NA Human Human +DTXSID5020368 TK.Half.Life NA 1.576 hours 1compartment NA NA Rat Human +DTXSID5020368 Css NA 0.1204 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020368 Css NA 0.623 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020368 Css NA 0.07458 mg/L PBTK NA 50% Rat Human +DTXSID5020368 Css NA 0.3626 mg/L PBTK NA 95% Rat Human +DTXSID5020441 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020441 Fup 0.0924 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020441 Vd NA 0.3292 L/kg 1compartment NA NA Human Human DTXSID5020441 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020441 TK.Half.Life NA 9.299 hours 1compartment NA NA Human Human -DTXSID5020441 Css NA 6.924 mg/L 3compartmentss NA 50% Human Human -DTXSID5020441 Css NA 54.13 mg/L 3compartmentss NA 95% Human Human -DTXSID5020441 Css NA 4.136 mg/L PBTK NA 50% Human Human -DTXSID5020441 Css NA 31.88 mg/L PBTK NA 95% Human Human -DTXSID5020441 Clint NA 3.924 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020441 Fup NA 0.0229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020441 Vd NA 0.2358 L/kg 1compartment NA NA Rat Human +DTXSID5020441 TK.Half.Life NA 2.273 hours 1compartment NA NA Human Human +DTXSID5020441 Css NA 1.014 mg/L 3compartmentss NA 50% Human Human +DTXSID5020441 Css NA 6.932 mg/L 3compartmentss NA 95% Human Human +DTXSID5020441 Css NA 0.6358 mg/L PBTK NA 50% Human Human +DTXSID5020441 Css NA 4.122 mg/L PBTK NA 95% Human Human +DTXSID5020441 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020441 Fup 0.0924 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020441 Vd NA 0.3251 L/kg 1compartment NA NA Rat Human DTXSID5020441 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020441 TK.Half.Life NA 5.519 hours 1compartment NA NA Rat Human -DTXSID5020441 Css NA 3.558 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020441 Css NA 22.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020441 Css NA 1.984 mg/L PBTK NA 50% Rat Human -DTXSID5020441 Css NA 12.17 mg/L PBTK NA 95% Rat Human -DTXSID5020443 Clint NA 82.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020443 Fup NA 0.0271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020443 Vd NA 2.436 L/kg 1compartment NA NA Human Human -DTXSID5020443 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020443 TK.Half.Life NA 8.025 hours 1compartment NA NA Human Human -DTXSID5020443 Css NA 0.3756 mg/L 3compartmentss NA 50% Human Human -DTXSID5020443 Css NA 2.936 mg/L 3compartmentss NA 95% Human Human -DTXSID5020443 Css NA 0.2485 mg/L PBTK NA 50% Human Human -DTXSID5020443 Css NA 1.851 mg/L PBTK NA 95% Human Human -DTXSID5020443 Clint NA 82.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020443 Fup NA 0.0271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020443 Vd NA 1.818 L/kg 1compartment NA NA Rat Human -DTXSID5020443 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020443 TK.Half.Life NA 2.196 hours 1compartment NA NA Rat Human -DTXSID5020443 Css NA 0.212 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020443 Css NA 1.385 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020443 Css NA 0.1331 mg/L PBTK NA 50% Rat Human -DTXSID5020443 Css NA 0.8379 mg/L PBTK NA 95% Rat Human -DTXSID5020445 Clint NA 85.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020445 Fup NA 0.0406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020445 Vd NA 2.581 L/kg 1compartment NA NA Human Human -DTXSID5020445 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020445 TK.Half.Life NA 7.302 hours 1compartment NA NA Human Human -DTXSID5020445 Css NA 0.3002 mg/L 3compartmentss NA 50% Human Human -DTXSID5020445 Css NA 2.149 mg/L 3compartmentss NA 95% Human Human -DTXSID5020445 Css NA 0.2016 mg/L PBTK NA 50% Human Human -DTXSID5020445 Css NA 1.405 mg/L PBTK NA 95% Human Human -DTXSID5020445 Clint NA 85.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020445 Fup NA 0.0406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020445 Vd NA 1.933 L/kg 1compartment NA NA Rat Human -DTXSID5020445 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020445 TK.Half.Life NA 1.899 hours 1compartment NA NA Rat Human -DTXSID5020445 Css NA 0.169 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020445 Css NA 0.9974 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020445 Css NA 0.1079 mg/L PBTK NA 50% Rat Human -DTXSID5020445 Css NA 0.6187 mg/L PBTK NA 95% Rat Human +DTXSID5020441 TK.Half.Life NA 1.376 hours 1compartment NA NA Rat Human +DTXSID5020441 Css NA 0.1227 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020441 Css NA 0.6486 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020441 Css NA 0.07484 mg/L PBTK NA 50% Rat Human +DTXSID5020441 Css NA 0.3734 mg/L PBTK NA 95% Rat Human +DTXSID5020443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020443 Fup 0.0208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020443 Vd NA 2.142 L/kg 1compartment NA NA Human Human +DTXSID5020443 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5020443 TK.Half.Life NA 22.26 hours 1compartment NA NA Human Human +DTXSID5020443 Css NA 1.509 mg/L 3compartmentss NA 50% Human Human +DTXSID5020443 Css NA 12.13 mg/L 3compartmentss NA 95% Human Human +DTXSID5020443 Css NA 0.979 mg/L PBTK NA 50% Human Human +DTXSID5020443 Css NA 7.622 mg/L PBTK NA 95% Human Human +DTXSID5020443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020443 Fup 0.0208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020443 Vd NA 1.594 L/kg 1compartment NA NA Rat Human +DTXSID5020443 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5020443 TK.Half.Life NA 6.717 hours 1compartment NA NA Rat Human +DTXSID5020443 Css NA 0.195 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020443 Css NA 1.308 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020443 Css NA 0.1235 mg/L PBTK NA 50% Rat Human +DTXSID5020443 Css NA 0.7864 mg/L PBTK NA 95% Rat Human +DTXSID5020445 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020445 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020445 Vd NA 2.138 L/kg 1compartment NA NA Human Human +DTXSID5020445 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5020445 TK.Half.Life NA 19.3 hours 1compartment NA NA Human Human +DTXSID5020445 Css NA 1.278 mg/L 3compartmentss NA 50% Human Human +DTXSID5020445 Css NA 9.995 mg/L 3compartmentss NA 95% Human Human +DTXSID5020445 Css NA 0.8292 mg/L PBTK NA 50% Human Human +DTXSID5020445 Css NA 6.218 mg/L PBTK NA 95% Human Human +DTXSID5020445 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020445 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020445 Vd NA 1.593 L/kg 1compartment NA NA Rat Human +DTXSID5020445 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5020445 TK.Half.Life NA 5.854 hours 1compartment NA NA Rat Human +DTXSID5020445 Css NA 0.1664 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020445 Css NA 1.084 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020445 Css NA 0.1053 mg/L PBTK NA 50% Rat Human +DTXSID5020445 Css NA 0.6508 mg/L PBTK NA 95% Rat Human +DTXSID5020447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020447 Fup 0.0067 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020447 Vd NA 1.89 L/kg 1compartment NA NA Human Human +DTXSID5020447 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5020447 TK.Half.Life NA 36.71 hours 1compartment NA NA Human Human +DTXSID5020447 Css NA 3.08 mg/L 3compartmentss NA 50% Human Human +DTXSID5020447 Css NA 26.86 mg/L 3compartmentss NA 95% Human Human +DTXSID5020447 Css NA 1.938 mg/L PBTK NA 50% Human Human +DTXSID5020447 Css NA 16.49 mg/L PBTK NA 95% Human Human +DTXSID5020447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020447 Fup 0.0067 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020447 Vd NA 1.397 L/kg 1compartment NA NA Rat Human +DTXSID5020447 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5020447 TK.Half.Life NA 12.3 hours 1compartment NA NA Rat Human +DTXSID5020447 Css NA 0.401 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020447 Css NA 2.824 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020447 Css NA 0.2464 mg/L PBTK NA 50% Rat Human +DTXSID5020447 Css NA 1.687 mg/L PBTK NA 95% Rat Human DTXSID5020449 Clint 86.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020449 Fup 1.18e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020449 Vd NA 0.1598 L/kg 1compartment NA NA Human Human DTXSID5020449 Days.Css NA 13 Days PBTK NA NA Human Human DTXSID5020449 TK.Half.Life NA 69.53 hours 1compartment NA NA Human Human -DTXSID5020449 Css NA 0.6852 mg/L 3compartmentss NA 50% Human Human -DTXSID5020449 Css NA 16.56 mg/L 3compartmentss NA 95% Human Human -DTXSID5020449 Css NA 0.3983 mg/L PBTK NA 50% Human Human -DTXSID5020449 Css NA 9.635 mg/L PBTK NA 95% Human Human +DTXSID5020449 Css NA 0.6707 mg/L 3compartmentss NA 50% Human Human +DTXSID5020449 Css NA 16.84 mg/L 3compartmentss NA 95% Human Human +DTXSID5020449 Css NA 0.3961 mg/L PBTK NA 50% Human Human +DTXSID5020449 Css NA 9.711 mg/L PBTK NA 95% Human Human DTXSID5020449 Clint 86.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020449 Fup 1.18e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020449 Vd NA 0.1581 L/kg 1compartment NA NA Rat Human DTXSID5020449 Days.Css NA 8 Days PBTK NA NA Rat Human DTXSID5020449 TK.Half.Life NA 47.94 hours 1compartment NA NA Rat Human -DTXSID5020449 Css NA 0.4003 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020449 Css NA 8.121 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020449 Css NA 0.2195 mg/L PBTK NA 50% Rat Human -DTXSID5020449 Css NA 4.41 mg/L PBTK NA 95% Rat Human -DTXSID5020491 Clint NA 27.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020491 Fup NA 0.0441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020491 Vd NA 2.993 L/kg 1compartment NA NA Human Human -DTXSID5020491 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5020491 TK.Half.Life NA 34.71 hours 1compartment NA NA Human Human -DTXSID5020491 Css NA 1.411 mg/L 3compartmentss NA 50% Human Human -DTXSID5020491 Css NA 9.18 mg/L 3compartmentss NA 95% Human Human -DTXSID5020491 Css NA 0.9686 mg/L PBTK NA 50% Human Human -DTXSID5020491 Css NA 6.163 mg/L PBTK NA 95% Human Human -DTXSID5020491 Clint NA 27.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020491 Fup NA 0.0441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020491 Vd NA 2.242 L/kg 1compartment NA NA Rat Human -DTXSID5020491 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5020491 TK.Half.Life NA 5.781 hours 1compartment NA NA Rat Human -DTXSID5020491 Css NA 0.7892 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020491 Css NA 4.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020491 Css NA 0.5198 mg/L PBTK NA 50% Rat Human -DTXSID5020491 Css NA 2.643 mg/L PBTK NA 95% Rat Human +DTXSID5020449 Css NA 0.0878 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020449 Css NA 1.755 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020449 Css NA 0.04994 mg/L PBTK NA 50% Rat Human +DTXSID5020449 Css NA 0.9893 mg/L PBTK NA 95% Rat Human +DTXSID5020491 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020491 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020491 Vd NA 2.867 L/kg 1compartment NA NA Human Human +DTXSID5020491 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5020491 TK.Half.Life NA 44.49 hours 1compartment NA NA Human Human +DTXSID5020491 Css NA 1.993 mg/L 3compartmentss NA 50% Human Human +DTXSID5020491 Css NA 13.55 mg/L 3compartmentss NA 95% Human Human +DTXSID5020491 Css NA 1.351 mg/L PBTK NA 50% Human Human +DTXSID5020491 Css NA 8.939 mg/L PBTK NA 95% Human Human +DTXSID5020491 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020491 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020491 Vd NA 2.146 L/kg 1compartment NA NA Rat Human +DTXSID5020491 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5020491 TK.Half.Life NA 8.214 hours 1compartment NA NA Rat Human +DTXSID5020491 Css NA 0.2571 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020491 Css NA 1.408 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020491 Css NA 0.1722 mg/L PBTK NA 50% Rat Human +DTXSID5020491 Css NA 0.9117 mg/L PBTK NA 95% Rat Human DTXSID5020493 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020493 Fup NA 0.7725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020493 Vd NA 0.7358 L/kg 1compartment NA NA Human Human +DTXSID5020493 Vd NA 0.7147 L/kg 1compartment NA NA Human Human DTXSID5020493 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020493 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human -DTXSID5020493 Css NA 1.009 mg/L 3compartmentss NA 50% Human Human -DTXSID5020493 Css NA 6.077 mg/L 3compartmentss NA 95% Human Human -DTXSID5020493 Css NA 0.8302 mg/L PBTK NA 50% Human Human -DTXSID5020493 Css NA 3.885 mg/L PBTK NA 95% Human Human +DTXSID5020493 TK.Half.Life NA 5.996 hours 1compartment NA NA Human Human +DTXSID5020493 Css NA 0.8762 mg/L 3compartmentss NA 50% Human Human +DTXSID5020493 Css NA 5.257 mg/L 3compartmentss NA 95% Human Human +DTXSID5020493 Css NA 0.7139 mg/L PBTK NA 50% Human Human +DTXSID5020493 Css NA 3.396 mg/L PBTK NA 95% Human Human DTXSID5020493 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020493 Fup NA 0.7725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020493 Vd NA 0.7574 L/kg 1compartment NA NA Rat Human +DTXSID5020493 Vd NA 0.7395 L/kg 1compartment NA NA Rat Human DTXSID5020493 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020493 TK.Half.Life NA 2.163 hours 1compartment NA NA Rat Human -DTXSID5020493 Css NA 0.2597 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020493 Css NA 1.615 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020493 Css NA 0.2068 mg/L PBTK NA 50% Rat Human -DTXSID5020493 Css NA 0.9613 mg/L PBTK NA 95% Rat Human -DTXSID5020497 Clint NA 0.5696 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020497 Fup NA 0.972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020497 Vd NA 1.016 L/kg 1compartment NA NA Human Human +DTXSID5020493 TK.Half.Life NA 2.111 hours 1compartment NA NA Rat Human +DTXSID5020493 Css NA 0.01638 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020493 Css NA 0.1289 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020493 Css NA 0.01281 mg/L PBTK NA 50% Rat Human +DTXSID5020493 Css NA 0.08279 mg/L PBTK NA 95% Rat Human +DTXSID5020497 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020497 Fup 0.73 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020497 Vd NA 0.8518 L/kg 1compartment NA NA Human Human DTXSID5020497 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020497 TK.Half.Life NA 3.656 hours 1compartment NA NA Human Human -DTXSID5020497 Css NA 0.4062 mg/L 3compartmentss NA 50% Human Human -DTXSID5020497 Css NA 1.466 mg/L 3compartmentss NA 95% Human Human -DTXSID5020497 Css NA 0.3584 mg/L PBTK NA 50% Human Human -DTXSID5020497 Css NA 1.098 mg/L PBTK NA 95% Human Human -DTXSID5020497 Clint NA 0.5696 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020497 Fup NA 0.972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020497 Vd NA 1.012 L/kg 1compartment NA NA Rat Human +DTXSID5020497 TK.Half.Life NA 7.632 hours 1compartment NA NA Human Human +DTXSID5020497 Css NA 0.9981 mg/L 3compartmentss NA 50% Human Human +DTXSID5020497 Css NA 6.44 mg/L 3compartmentss NA 95% Human Human +DTXSID5020497 Css NA 0.8426 mg/L PBTK NA 50% Human Human +DTXSID5020497 Css NA 4.16 mg/L PBTK NA 95% Human Human +DTXSID5020497 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020497 Fup 0.73 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020497 Vd NA 0.8471 L/kg 1compartment NA NA Rat Human DTXSID5020497 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020497 TK.Half.Life NA 1.603 hours 1compartment NA NA Rat Human -DTXSID5020497 Css NA 0.139 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020497 Css NA 0.4478 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020497 Css NA 0.1223 mg/L PBTK NA 50% Rat Human -DTXSID5020497 Css NA 0.3046 mg/L PBTK NA 95% Rat Human +DTXSID5020497 TK.Half.Life NA 2.565 hours 1compartment NA NA Rat Human +DTXSID5020497 Css NA 0.05965 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020497 Css NA 0.3744 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020497 Css NA 0.05039 mg/L PBTK NA 50% Rat Human +DTXSID5020497 Css NA 0.2326 mg/L PBTK NA 95% Rat Human DTXSID5020499 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020499 Fup NA 0.976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020499 Vd NA 0.807 L/kg 1compartment NA NA Human Human DTXSID5020499 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5020499 TK.Half.Life NA 5.357 hours 1compartment NA NA Human Human -DTXSID5020499 Css NA 0.8723 mg/L 3compartmentss NA 50% Human Human -DTXSID5020499 Css NA 4.912 mg/L 3compartmentss NA 95% Human Human -DTXSID5020499 Css NA 0.7348 mg/L PBTK NA 50% Human Human -DTXSID5020499 Css NA 3.269 mg/L PBTK NA 95% Human Human +DTXSID5020499 Css NA 0.7428 mg/L 3compartmentss NA 50% Human Human +DTXSID5020499 Css NA 4.366 mg/L 3compartmentss NA 95% Human Human +DTXSID5020499 Css NA 0.6252 mg/L PBTK NA 50% Human Human +DTXSID5020499 Css NA 2.874 mg/L PBTK NA 95% Human Human DTXSID5020499 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020499 Fup NA 0.976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020499 Vd NA 0.839 L/kg 1compartment NA NA Rat Human DTXSID5020499 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020499 TK.Half.Life NA 1.896 hours 1compartment NA NA Rat Human -DTXSID5020499 Css NA 0.2217 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020499 Css NA 1.244 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020499 Css NA 0.182 mg/L PBTK NA 50% Rat Human -DTXSID5020499 Css NA 0.7561 mg/L PBTK NA 95% Rat Human +DTXSID5020499 Css NA 0.01384 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020499 Css NA 0.1014 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020499 Css NA 0.01116 mg/L PBTK NA 50% Rat Human +DTXSID5020499 Css NA 0.06801 mg/L PBTK NA 95% Rat Human DTXSID5020528 Clint 34.64 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5020528 Fup 0.131 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5020528 Vd NA 0.9657 L/kg 1compartment NA NA Human Human DTXSID5020528 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5020528 TK.Half.Life NA 1.63 hours 1compartment NA NA Human Human -DTXSID5020528 Css NA 0.135 mg/L 3compartmentss NA 50% Human Human -DTXSID5020528 Css NA 1.124 mg/L 3compartmentss NA 95% Human Human -DTXSID5020528 Css NA 0.08934 mg/L PBTK NA 50% Human Human -DTXSID5020528 Css NA 0.6906 mg/L PBTK NA 95% Human Human +DTXSID5020528 Css NA 0.1288 mg/L 3compartmentss NA 50% Human Human +DTXSID5020528 Css NA 1.119 mg/L 3compartmentss NA 95% Human Human +DTXSID5020528 Css NA 0.08508 mg/L PBTK NA 50% Human Human +DTXSID5020528 Css NA 0.685 mg/L PBTK NA 95% Human Human DTXSID5020528 Clint 34.64 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5020528 Fup 0.131 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5020528 Vd NA 0.7759 L/kg 1compartment NA NA Rat Human DTXSID5020528 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020528 TK.Half.Life NA 0.6968 hours 1compartment NA NA Rat Human -DTXSID5020528 Css NA 0.07654 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020528 Css NA 0.4915 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020528 Css NA 0.04788 mg/L PBTK NA 50% Rat Human -DTXSID5020528 Css NA 0.2839 mg/L PBTK NA 95% Rat Human -DTXSID5020570 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020570 Fup NA 0.781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020570 Vd NA 0.412 L/kg 1compartment NA NA Human Human +DTXSID5020528 Css NA 0.01674 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020528 Css NA 0.1128 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020528 Css NA 0.01085 mg/L PBTK NA 50% Rat Human +DTXSID5020528 Css NA 0.06943 mg/L PBTK NA 95% Rat Human +DTXSID5020570 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020570 Fup 0.806 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020570 Vd NA 0.4432 L/kg 1compartment NA NA Human Human DTXSID5020570 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020570 TK.Half.Life NA 3.413 hours 1compartment NA NA Human Human -DTXSID5020570 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID5020570 Css NA 6.477 mg/L 3compartmentss NA 95% Human Human -DTXSID5020570 Css NA 0.8255 mg/L PBTK NA 50% Human Human -DTXSID5020570 Css NA 3.964 mg/L PBTK NA 95% Human Human -DTXSID5020570 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020570 Fup NA 0.781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020570 Vd NA 0.4371 L/kg 1compartment NA NA Rat Human +DTXSID5020570 TK.Half.Life NA 3.558 hours 1compartment NA NA Human Human +DTXSID5020570 Css NA 0.9552 mg/L 3compartmentss NA 50% Human Human +DTXSID5020570 Css NA 5.414 mg/L 3compartmentss NA 95% Human Human +DTXSID5020570 Css NA 0.701 mg/L PBTK NA 50% Human Human +DTXSID5020570 Css NA 3.373 mg/L PBTK NA 95% Human Human +DTXSID5020570 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020570 Fup 0.806 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020570 Vd NA 0.4652 L/kg 1compartment NA NA Rat Human DTXSID5020570 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020570 TK.Half.Life NA 1.234 hours 1compartment NA NA Rat Human -DTXSID5020570 Css NA 0.298 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020570 Css NA 1.658 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020570 Css NA 0.2056 mg/L PBTK NA 50% Rat Human -DTXSID5020570 Css NA 0.9495 mg/L PBTK NA 95% Rat Human -DTXSID5020572 Clint NA 3.852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020572 Fup NA 0.1086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020572 Vd NA 1.276 L/kg 1compartment NA NA Human Human -DTXSID5020572 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5020572 TK.Half.Life NA 12.31 hours 1compartment NA NA Human Human -DTXSID5020572 Css NA 1.375 mg/L 3compartmentss NA 50% Human Human -DTXSID5020572 Css NA 8.444 mg/L 3compartmentss NA 95% Human Human -DTXSID5020572 Css NA 0.9118 mg/L PBTK NA 50% Human Human -DTXSID5020572 Css NA 5.194 mg/L PBTK NA 95% Human Human -DTXSID5020572 Clint NA 3.852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020572 Fup NA 0.1086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020572 Vd NA 0.9893 L/kg 1compartment NA NA Rat Human -DTXSID5020572 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020572 TK.Half.Life NA 4.916 hours 1compartment NA NA Rat Human -DTXSID5020572 Css NA 0.6972 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020572 Css NA 3.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020572 Css NA 0.4366 mg/L PBTK NA 50% Rat Human -DTXSID5020572 Css NA 1.791 mg/L PBTK NA 95% Rat Human +DTXSID5020570 TK.Half.Life NA 1.273 hours 1compartment NA NA Rat Human +DTXSID5020570 Css NA 0.02509 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020570 Css NA 0.1567 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020570 Css NA 0.01766 mg/L PBTK NA 50% Rat Human +DTXSID5020570 Css NA 0.09591 mg/L PBTK NA 95% Rat Human +DTXSID5020572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020572 Fup 0.0271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020572 Vd NA 2.951 L/kg 1compartment NA NA Human Human +DTXSID5020572 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID5020572 TK.Half.Life NA 48.74 hours 1compartment NA NA Human Human +DTXSID5020572 Css NA 2.068 mg/L 3compartmentss NA 50% Human Human +DTXSID5020572 Css NA 14.22 mg/L 3compartmentss NA 95% Human Human +DTXSID5020572 Css NA 1.421 mg/L PBTK NA 50% Human Human +DTXSID5020572 Css NA 9.366 mg/L PBTK NA 95% Human Human +DTXSID5020572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020572 Fup 0.0271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020572 Vd NA 2.209 L/kg 1compartment NA NA Rat Human +DTXSID5020572 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5020572 TK.Half.Life NA 8.272 hours 1compartment NA NA Rat Human +DTXSID5020572 Css NA 0.2653 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020572 Css NA 1.496 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020572 Css NA 0.1793 mg/L PBTK NA 50% Rat Human +DTXSID5020572 Css NA 0.9852 mg/L PBTK NA 95% Rat Human DTXSID5020576 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020576 Fup 0.014 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5020576 Vd NA 2.765 L/kg 1compartment NA NA Human Human -DTXSID5020576 Days.Css NA 505 Days PBTK NA NA Human Human +DTXSID5020576 Days.Css NA 508 Days PBTK NA NA Human Human DTXSID5020576 TK.Half.Life NA 1888 hours 1compartment NA NA Human Human -DTXSID5020576 Css NA 50.83 mg/L 3compartmentss NA 50% Human Human -DTXSID5020576 Css NA 414 mg/L 3compartmentss NA 95% Human Human -DTXSID5020576 Css NA 60.94 mg/L PBTK NA 50% Human Human -DTXSID5020576 Css NA 312.1 mg/L PBTK NA 95% Human Human +DTXSID5020576 Css NA 50.58 mg/L 3compartmentss NA 50% Human Human +DTXSID5020576 Css NA 418 mg/L 3compartmentss NA 95% Human Human +DTXSID5020576 Css NA 59.66 mg/L PBTK NA 50% Human Human +DTXSID5020576 Css NA 307.7 mg/L PBTK NA 95% Human Human DTXSID5020576 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020576 Fup 0.014 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5020576 Vd NA 2.5 L/kg 1compartment NA NA Rat Human DTXSID5020576 Days.Css NA 151 Days PBTK NA NA Rat Human DTXSID5020576 TK.Half.Life NA 438.4 hours 1compartment NA NA Rat Human -DTXSID5020576 Css NA 14.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020576 Css NA 110.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020576 Css NA 16.6 mg/L PBTK NA 50% Rat Human -DTXSID5020576 Css NA 75.26 mg/L PBTK NA 95% Rat Human +DTXSID5020576 Css NA 3.178 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020576 Css NA 24.02 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020576 Css NA 3.86 mg/L PBTK NA 50% Rat Human +DTXSID5020576 Css NA 17.04 mg/L PBTK NA 95% Rat Human DTXSID5020601 Clint NA 0.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020601 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020601 Vd NA 0.8308 L/kg 1compartment NA NA Human Human +DTXSID5020601 Vd NA 0.8309 L/kg 1compartment NA NA Human Human DTXSID5020601 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5020601 TK.Half.Life NA 4.173 hours 1compartment NA NA Human Human -DTXSID5020601 Css NA 0.6128 mg/L 3compartmentss NA 50% Human Human -DTXSID5020601 Css NA 4.218 mg/L 3compartmentss NA 95% Human Human -DTXSID5020601 Css NA 0.5244 mg/L PBTK NA 50% Human Human -DTXSID5020601 Css NA 2.708 mg/L PBTK NA 95% Human Human +DTXSID5020601 Css NA 0.5218 mg/L 3compartmentss NA 50% Human Human +DTXSID5020601 Css NA 3.41 mg/L 3compartmentss NA 95% Human Human +DTXSID5020601 Css NA 0.4468 mg/L PBTK NA 50% Human Human +DTXSID5020601 Css NA 2.232 mg/L PBTK NA 95% Human Human DTXSID5020601 Clint NA 0.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020601 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020601 Vd NA 0.862 L/kg 1compartment NA NA Rat Human DTXSID5020601 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020601 TK.Half.Life NA 1.665 hours 1compartment NA NA Rat Human -DTXSID5020601 Css NA 0.179 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020601 Css NA 1.115 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020601 Css NA 0.1505 mg/L PBTK NA 50% Rat Human -DTXSID5020601 Css NA 0.6763 mg/L PBTK NA 95% Rat Human -DTXSID5020603 Clint NA 2.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020603 Fup NA 0.6137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020603 Vd NA 1.674 L/kg 1compartment NA NA Human Human +DTXSID5020601 Css NA 0.01094 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020601 Css NA 0.08656 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020601 Css NA 0.009053 mg/L PBTK NA 50% Rat Human +DTXSID5020601 Css NA 0.05743 mg/L PBTK NA 95% Rat Human +DTXSID5020603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020603 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020603 Vd NA 0.5143 L/kg 1compartment NA NA Human Human DTXSID5020603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020603 TK.Half.Life NA 4.643 hours 1compartment NA NA Human Human -DTXSID5020603 Css NA 0.2492 mg/L 3compartmentss NA 50% Human Human -DTXSID5020603 Css NA 2.105 mg/L 3compartmentss NA 95% Human Human -DTXSID5020603 Css NA 0.2312 mg/L PBTK NA 50% Human Human -DTXSID5020603 Css NA 1.433 mg/L PBTK NA 95% Human Human -DTXSID5020603 Clint NA 2.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020603 Fup NA 0.6137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020603 Vd NA 1.652 L/kg 1compartment NA NA Rat Human +DTXSID5020603 TK.Half.Life NA 7.265 hours 1compartment NA NA Human Human +DTXSID5020603 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human +DTXSID5020603 Css NA 6.468 mg/L 3compartmentss NA 95% Human Human +DTXSID5020603 Css NA 1.028 mg/L PBTK NA 50% Human Human +DTXSID5020603 Css NA 4.122 mg/L PBTK NA 95% Human Human +DTXSID5020603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020603 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020603 Vd NA 0.535 L/kg 1compartment NA NA Rat Human DTXSID5020603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020603 TK.Half.Life NA 2.392 hours 1compartment NA NA Rat Human -DTXSID5020603 Css NA 0.1056 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020603 Css NA 0.8671 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020603 Css NA 0.09698 mg/L PBTK NA 50% Rat Human -DTXSID5020603 Css NA 0.5338 mg/L PBTK NA 95% Rat Human -DTXSID5020605 Clint NA 5.786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020605 Fup NA 0.352 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020605 Vd NA 2.58 L/kg 1compartment NA NA Human Human +DTXSID5020603 TK.Half.Life NA 2.575 hours 1compartment NA NA Rat Human +DTXSID5020603 Css NA 0.03363 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020603 Css NA 0.2106 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020603 Css NA 0.0248 mg/L PBTK NA 50% Rat Human +DTXSID5020603 Css NA 0.1318 mg/L PBTK NA 95% Rat Human +DTXSID5020605 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020605 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020605 Vd NA 2.712 L/kg 1compartment NA NA Human Human DTXSID5020605 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020605 TK.Half.Life NA 12.66 hours 1compartment NA NA Human Human -DTXSID5020605 Css NA 0.4916 mg/L 3compartmentss NA 50% Human Human -DTXSID5020605 Css NA 2.603 mg/L 3compartmentss NA 95% Human Human -DTXSID5020605 Css NA 0.3736 mg/L PBTK NA 50% Human Human -DTXSID5020605 Css NA 1.862 mg/L PBTK NA 95% Human Human -DTXSID5020605 Clint NA 5.786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020605 Fup NA 0.352 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020605 Vd NA 1.988 L/kg 1compartment NA NA Rat Human +DTXSID5020605 TK.Half.Life NA 6.466 hours 1compartment NA NA Human Human +DTXSID5020605 Css NA 0.1884 mg/L 3compartmentss NA 50% Human Human +DTXSID5020605 Css NA 1.259 mg/L 3compartmentss NA 95% Human Human +DTXSID5020605 Css NA 0.1405 mg/L PBTK NA 50% Human Human +DTXSID5020605 Css NA 0.8826 mg/L PBTK NA 95% Human Human +DTXSID5020605 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020605 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020605 Vd NA 2.073 L/kg 1compartment NA NA Rat Human DTXSID5020605 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020605 TK.Half.Life NA 3.177 hours 1compartment NA NA Rat Human -DTXSID5020605 Css NA 0.2535 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020605 Css NA 0.9467 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020605 Css NA 0.1863 mg/L PBTK NA 50% Rat Human -DTXSID5020605 Css NA 0.6499 mg/L PBTK NA 95% Rat Human +DTXSID5020605 TK.Half.Life NA 1.648 hours 1compartment NA NA Rat Human +DTXSID5020605 Css NA 0.02388 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020605 Css NA 0.1205 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020605 Css NA 0.01779 mg/L PBTK NA 50% Rat Human +DTXSID5020605 Css NA 0.08412 mg/L PBTK NA 95% Rat Human DTXSID5020607 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID5020607 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020607 Vd NA 39.34 L/kg 1compartment NA NA Human Human -DTXSID5020607 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID5020607 TK.Half.Life NA 1899000 hours 1compartment NA NA Human Human -DTXSID5020607 Css NA 889.4 mg/L 3compartmentss NA 50% Human Human -DTXSID5020607 Css NA 2218 mg/L 3compartmentss NA 95% Human Human -DTXSID5020607 Css NA 3750 mg/L PBTK NA 50% Human Human -DTXSID5020607 Css NA 7999 mg/L PBTK NA 95% Human Human +DTXSID5020607 Fup 0.00693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020607 Vd NA 40.16 L/kg 1compartment NA NA Human Human +DTXSID5020607 Days.Css NA 19030 Days PBTK NA NA Human Human +DTXSID5020607 TK.Half.Life NA 1936000 hours 1compartment NA NA Human Human +DTXSID5020607 Css NA 831.4 mg/L 3compartmentss NA 50% Human Human +DTXSID5020607 Css NA 2128 mg/L 3compartmentss NA 95% Human Human +DTXSID5020607 Css NA 3613 mg/L PBTK NA 50% Human Human +DTXSID5020607 Css NA 7782 mg/L PBTK NA 95% Human Human DTXSID5020607 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5020607 Fup 0.2152 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID5020607 Vd NA 33.46 L/kg 1compartment NA NA Rat Rat -DTXSID5020607 Days.Css NA 3276 Days PBTK NA NA Rat Rat -DTXSID5020607 TK.Half.Life NA 128700 hours 1compartment NA NA Rat Rat -DTXSID5020607 Css NA 203.7 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5020607 Css NA 368.8 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5020607 Css NA 964.6 mg/L PBTK NA 50% Rat Rat -DTXSID5020607 Css NA 1325 mg/L PBTK NA 95% Rat Rat +DTXSID5020607 Vd NA 34.1 L/kg 1compartment NA NA Rat Rat +DTXSID5020607 Days.Css NA 8526 Days PBTK NA NA Rat Rat +DTXSID5020607 TK.Half.Life NA 131200 hours 1compartment NA NA Rat Rat +DTXSID5020607 Css NA 45.2 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5020607 Css NA 81.94 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5020607 Css NA 225.7 mg/L PBTK NA 50% Rat Rat +DTXSID5020607 Css NA 311.1 mg/L PBTK NA 95% Rat Rat DTXSID5020653 Clint 8.322 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5020653 Fup 0.01384 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5020653 Vd NA 2.038 L/kg 1compartment NA NA Human Human +DTXSID5020653 Vd NA 0.2925 L/kg 1compartment NA NA Human Human DTXSID5020653 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020653 TK.Half.Life NA 10.33 hours 1compartment NA NA Human Human -DTXSID5020653 Css NA 0.668 mg/L 3compartmentss NA 50% Human Human -DTXSID5020653 Css NA 7.221 mg/L 3compartmentss NA 95% Human Human -DTXSID5020653 Css NA 0.467 mg/L PBTK NA 50% Human Human -DTXSID5020653 Css NA 4.534 mg/L PBTK NA 95% Human Human +DTXSID5020653 TK.Half.Life NA 9.355 hours 1compartment NA NA Human Human +DTXSID5020653 Css NA 5.81 mg/L 3compartmentss NA 50% Human Human +DTXSID5020653 Css NA 50.28 mg/L 3compartmentss NA 95% Human Human +DTXSID5020653 Css NA 3.428 mg/L PBTK NA 50% Human Human +DTXSID5020653 Css NA 29.2 mg/L PBTK NA 95% Human Human DTXSID5020653 Clint 8.322 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5020653 Fup 0.01384 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5020653 Vd NA 1.731 L/kg 1compartment NA NA Rat Human +DTXSID5020653 Vd NA 0.2835 L/kg 1compartment NA NA Rat Human DTXSID5020653 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020653 TK.Half.Life NA 4.674 hours 1compartment NA NA Rat Human -DTXSID5020653 Css NA 0.3836 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020653 Css NA 3.145 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020653 Css NA 0.2514 mg/L PBTK NA 50% Rat Human -DTXSID5020653 Css NA 1.874 mg/L PBTK NA 95% Rat Human +DTXSID5020653 TK.Half.Life NA 5.884 hours 1compartment NA NA Rat Human +DTXSID5020653 Css NA 0.7272 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020653 Css NA 5.143 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020653 Css NA 0.4146 mg/L PBTK NA 50% Rat Human +DTXSID5020653 Css NA 2.888 mg/L PBTK NA 95% Rat Human DTXSID5020659 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020659 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5020659 Vd NA 0.6057 L/kg 1compartment NA NA Human Human DTXSID5020659 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5020659 TK.Half.Life NA 4.63 hours 1compartment NA NA Human Human -DTXSID5020659 Css NA 0.9964 mg/L 3compartmentss NA 50% Human Human -DTXSID5020659 Css NA 5.933 mg/L 3compartmentss NA 95% Human Human -DTXSID5020659 Css NA 0.7897 mg/L PBTK NA 50% Human Human -DTXSID5020659 Css NA 3.798 mg/L PBTK NA 95% Human Human +DTXSID5020659 Css NA 0.8449 mg/L 3compartmentss NA 50% Human Human +DTXSID5020659 Css NA 5.012 mg/L 3compartmentss NA 95% Human Human +DTXSID5020659 Css NA 0.6738 mg/L PBTK NA 50% Human Human +DTXSID5020659 Css NA 3.19 mg/L PBTK NA 95% Human Human DTXSID5020659 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020659 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5020659 Vd NA 0.6562 L/kg 1compartment NA NA Rat Human DTXSID5020659 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020659 TK.Half.Life NA 1.71 hours 1compartment NA NA Rat Human -DTXSID5020659 Css NA 0.2553 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020659 Css NA 1.448 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020659 Css NA 0.1961 mg/L PBTK NA 50% Rat Human -DTXSID5020659 Css NA 0.8574 mg/L PBTK NA 95% Rat Human +DTXSID5020659 Css NA 0.01587 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020659 Css NA 0.1173 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020659 Css NA 0.01204 mg/L PBTK NA 50% Rat Human +DTXSID5020659 Css NA 0.07397 mg/L PBTK NA 95% Rat Human +DTXSID50207128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50207128 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50207128 Vd NA 2.378 L/kg 1compartment NA NA Human Human +DTXSID50207128 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50207128 TK.Half.Life NA 3.815 hours 1compartment NA NA Human Human +DTXSID50207128 Css NA 0.102 mg/L 3compartmentss NA 50% Human Human +DTXSID50207128 Css NA 0.6799 mg/L 3compartmentss NA 95% Human Human +DTXSID50207128 Css NA 0.07891 mg/L PBTK NA 50% Human Human +DTXSID50207128 Css NA 0.4982 mg/L PBTK NA 95% Human Human +DTXSID50207128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50207128 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50207128 Vd NA 1.85 L/kg 1compartment NA NA Rat Human +DTXSID50207128 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50207128 TK.Half.Life NA 1.185 hours 1compartment NA NA Rat Human +DTXSID50207128 Css NA 0.0127 mg/L 3compartmentss NA 50% Rat Human +DTXSID50207128 Css NA 0.06322 mg/L 3compartmentss NA 95% Rat Human +DTXSID50207128 Css NA 0.009847 mg/L PBTK NA 50% Rat Human +DTXSID50207128 Css NA 0.04585 mg/L PBTK NA 95% Rat Human DTXSID5020730 Clint 69.68 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5020730 Fup 0.1184 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5020730 Vd NA 0.849 L/kg 1compartment NA NA Human Human DTXSID5020730 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5020730 TK.Half.Life NA 1.117 hours 1compartment NA NA Human Human -DTXSID5020730 Css NA 0.07678 mg/L 3compartmentss NA 50% Human Human -DTXSID5020730 Css NA 0.6378 mg/L 3compartmentss NA 95% Human Human -DTXSID5020730 Css NA 0.05004 mg/L PBTK NA 50% Human Human -DTXSID5020730 Css NA 0.3961 mg/L PBTK NA 95% Human Human +DTXSID5020730 Css NA 0.07193 mg/L 3compartmentss NA 50% Human Human +DTXSID5020730 Css NA 0.635 mg/L 3compartmentss NA 95% Human Human +DTXSID5020730 Css NA 0.04652 mg/L PBTK NA 50% Human Human +DTXSID5020730 Css NA 0.397 mg/L PBTK NA 95% Human Human DTXSID5020730 Clint 69.68 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5020730 Fup 0.1184 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5020730 Vd NA 0.6887 L/kg 1compartment NA NA Rat Human DTXSID5020730 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020730 TK.Half.Life NA 0.4621 hours 1compartment NA NA Rat Human -DTXSID5020730 Css NA 0.04292 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020730 Css NA 0.2945 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020730 Css NA 0.02636 mg/L PBTK NA 50% Rat Human -DTXSID5020730 Css NA 0.1713 mg/L PBTK NA 95% Rat Human +DTXSID5020730 Css NA 0.009512 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020730 Css NA 0.0667 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020730 Css NA 0.00606 mg/L PBTK NA 50% Rat Human +DTXSID5020730 Css NA 0.04011 mg/L PBTK NA 95% Rat Human DTXSID5020732 Clint 10.12 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5020732 Fup 0.01 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID5020732 Vd NA 0.6153 L/kg 1compartment NA NA Human Human +DTXSID5020732 Vd NA 0.6151 L/kg 1compartment NA NA Human Human DTXSID5020732 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID5020732 TK.Half.Life NA 22.37 hours 1compartment NA NA Human Human -DTXSID5020732 Css NA 5.946 mg/L 3compartmentss NA 50% Human Human -DTXSID5020732 Css NA 53.63 mg/L 3compartmentss NA 95% Human Human -DTXSID5020732 Css NA 3.382 mg/L PBTK NA 50% Human Human -DTXSID5020732 Css NA 31.11 mg/L PBTK NA 95% Human Human +DTXSID5020732 Css NA 7.082 mg/L 3compartmentss NA 50% Human Human +DTXSID5020732 Css NA 64.31 mg/L 3compartmentss NA 95% Human Human +DTXSID5020732 Css NA 3.894 mg/L PBTK NA 50% Human Human +DTXSID5020732 Css NA 35.37 mg/L PBTK NA 95% Human Human DTXSID5020732 Clint 5.9 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5020732 Fup 0.023 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID5020732 Vd NA 0.9978 L/kg 1compartment NA NA Rat Rat +DTXSID5020732 Vd 0.53 0.9972 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID5020732 Days.Css NA 2 Days PBTK NA NA Rat Rat -DTXSID5020732 TK.Half.Life NA 16.56 hours 1compartment NA NA Rat Rat -DTXSID5020732 Css NA 2.671 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5020732 Css NA 16.61 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5020732 Css NA 1.421 mg/L PBTK NA 50% Rat Rat -DTXSID5020732 Css NA 8.937 mg/L PBTK NA 95% Rat Rat -DTXSID5020738 Clint NA 0.9141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020738 Fup NA 0.072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020738 Vd NA 0.2269 L/kg 1compartment NA NA Human Human +DTXSID5020732 TK.Half.Life 0.84 16.55 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID5020732 Css 0.096 0.5858 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID5020732 Css 0.096 3.796 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID5020732 Css 0.096 0.3337 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID5020732 Css 0.096 2.162 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID5020738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020738 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020738 Vd NA 0.3702 L/kg 1compartment NA NA Human Human DTXSID5020738 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020738 TK.Half.Life NA 8.191 hours 1compartment NA NA Human Human -DTXSID5020738 Css NA 5.983 mg/L 3compartmentss NA 50% Human Human -DTXSID5020738 Css NA 28.72 mg/L 3compartmentss NA 95% Human Human -DTXSID5020738 Css NA 3.604 mg/L PBTK NA 50% Human Human -DTXSID5020738 Css NA 16.79 mg/L PBTK NA 95% Human Human -DTXSID5020738 Clint NA 0.9141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020738 Fup NA 0.072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020738 Vd NA 0.2249 L/kg 1compartment NA NA Rat Human +DTXSID5020738 TK.Half.Life NA 0.5208 hours 1compartment NA NA Human Human +DTXSID5020738 Css NA 0.07758 mg/L 3compartmentss NA 50% Human Human +DTXSID5020738 Css NA 0.5655 mg/L 3compartmentss NA 95% Human Human +DTXSID5020738 Css NA 0.05179 mg/L PBTK NA 50% Human Human +DTXSID5020738 Css NA 0.3608 mg/L PBTK NA 95% Human Human +DTXSID5020738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020738 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020738 Vd NA 0.3701 L/kg 1compartment NA NA Rat Human DTXSID5020738 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020738 TK.Half.Life NA 3.986 hours 1compartment NA NA Rat Human -DTXSID5020738 Css NA 2.47 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020738 Css NA 9.333 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020738 Css NA 1.387 mg/L PBTK NA 50% Rat Human -DTXSID5020738 Css NA 5.097 mg/L PBTK NA 95% Rat Human -DTXSID5020782 Clint NA 0.9299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020782 Fup NA 0.0029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020782 Vd NA 0.4711 L/kg 1compartment NA NA Human Human -DTXSID5020782 Days.Css NA 87 Days PBTK NA NA Human Human -DTXSID5020782 TK.Half.Life NA 348.1 hours 1compartment NA NA Human Human -DTXSID5020782 Css NA 134.5 mg/L 3compartmentss NA 50% Human Human -DTXSID5020782 Css NA 604.9 mg/L 3compartmentss NA 95% Human Human -DTXSID5020782 Css NA 79.19 mg/L PBTK NA 50% Human Human -DTXSID5020782 Css NA 351.2 mg/L PBTK NA 95% Human Human -DTXSID5020782 Clint NA 0.9299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020782 Fup NA 0.0029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020782 Vd NA 0.355 L/kg 1compartment NA NA Rat Human -DTXSID5020782 Days.Css NA 31 Days PBTK NA NA Rat Human -DTXSID5020782 TK.Half.Life NA 133.7 hours 1compartment NA NA Rat Human -DTXSID5020782 Css NA 59.64 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020782 Css NA 208.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020782 Css NA 32.57 mg/L PBTK NA 50% Rat Human -DTXSID5020782 Css NA 112.8 mg/L PBTK NA 95% Rat Human +DTXSID5020738 TK.Half.Life NA 0.2778 hours 1compartment NA NA Rat Human +DTXSID5020738 Css NA 0.009522 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020738 Css NA 0.05456 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020738 Css NA 0.006306 mg/L PBTK NA 50% Rat Human +DTXSID5020738 Css NA 0.03409 mg/L PBTK NA 95% Rat Human +DTXSID5020782 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020782 Fup 0.0266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020782 Vd NA 0.8957 L/kg 1compartment NA NA Human Human +DTXSID5020782 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5020782 TK.Half.Life NA 6.313 hours 1compartment NA NA Human Human +DTXSID5020782 Css NA 1.104 mg/L 3compartmentss NA 50% Human Human +DTXSID5020782 Css NA 10.58 mg/L 3compartmentss NA 95% Human Human +DTXSID5020782 Css NA 0.6762 mg/L PBTK NA 50% Human Human +DTXSID5020782 Css NA 6.336 mg/L PBTK NA 95% Human Human +DTXSID5020782 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020782 Fup 0.0266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020782 Vd NA 0.6721 L/kg 1compartment NA NA Rat Human +DTXSID5020782 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5020782 TK.Half.Life NA 2.825 hours 1compartment NA NA Rat Human +DTXSID5020782 Css NA 0.1447 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020782 Css NA 1.077 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020782 Css NA 0.08576 mg/L PBTK NA 50% Rat Human +DTXSID5020782 Css NA 0.6144 mg/L PBTK NA 95% Rat Human DTXSID5020784 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5020784 Fup 0.01429 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5020784 Vd NA 1.434 L/kg 1compartment NA NA Human Human DTXSID5020784 Days.Css NA 195 Days PBTK NA NA Human Human DTXSID5020784 TK.Half.Life NA 767.5 hours 1compartment NA NA Human Human -DTXSID5020784 Css NA 81.84 mg/L 3compartmentss NA 50% Human Human -DTXSID5020784 Css NA 486.4 mg/L 3compartmentss NA 95% Human Human -DTXSID5020784 Css NA 52.81 mg/L PBTK NA 50% Human Human -DTXSID5020784 Css NA 292.1 mg/L PBTK NA 95% Human Human +DTXSID5020784 Css NA 79.47 mg/L 3compartmentss NA 50% Human Human +DTXSID5020784 Css NA 468.5 mg/L 3compartmentss NA 95% Human Human +DTXSID5020784 Css NA 51.58 mg/L PBTK NA 50% Human Human +DTXSID5020784 Css NA 276.9 mg/L PBTK NA 95% Human Human DTXSID5020784 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID5020784 Fup 0.01429 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5020784 Vd NA 1.211 L/kg 1compartment NA NA Rat Human DTXSID5020784 Days.Css NA 53 Days PBTK NA NA Rat Human DTXSID5020784 TK.Half.Life NA 194.9 hours 1compartment NA NA Rat Human -DTXSID5020784 Css NA 23.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020784 Css NA 120.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020784 Css NA 14.07 mg/L PBTK NA 50% Rat Human -DTXSID5020784 Css NA 66.74 mg/L PBTK NA 95% Rat Human -DTXSID5020811 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020811 Fup NA 0.2346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020811 Vd NA 0.3099 L/kg 1compartment NA NA Human Human -DTXSID5020811 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020811 TK.Half.Life NA 8.548 hours 1compartment NA NA Human Human -DTXSID5020811 Css NA 3.481 mg/L 3compartmentss NA 50% Human Human -DTXSID5020811 Css NA 12.34 mg/L 3compartmentss NA 95% Human Human -DTXSID5020811 Css NA 2.272 mg/L PBTK NA 50% Human Human -DTXSID5020811 Css NA 7.52 mg/L PBTK NA 95% Human Human -DTXSID5020811 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020811 Fup NA 0.2346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020811 Vd NA 0.3311 L/kg 1compartment NA NA Rat Human -DTXSID5020811 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020811 TK.Half.Life NA 3.112 hours 1compartment NA NA Rat Human -DTXSID5020811 Css NA 0.9676 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020811 Css NA 2.962 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020811 Css NA 0.594 mg/L PBTK NA 50% Rat Human -DTXSID5020811 Css NA 1.677 mg/L PBTK NA 95% Rat Human -DTXSID5020813 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020813 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020813 Vd NA 3.013 L/kg 1compartment NA NA Human Human -DTXSID5020813 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID5020813 TK.Half.Life NA 115.7 hours 1compartment NA NA Human Human -DTXSID5020813 Css NA 3.779 mg/L 3compartmentss NA 50% Human Human -DTXSID5020813 Css NA 15.64 mg/L 3compartmentss NA 95% Human Human -DTXSID5020813 Css NA 3.146 mg/L PBTK NA 50% Human Human -DTXSID5020813 Css NA 10.96 mg/L PBTK NA 95% Human Human -DTXSID5020813 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020813 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020813 Vd NA 2.342 L/kg 1compartment NA NA Rat Human -DTXSID5020813 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5020813 TK.Half.Life NA 11.23 hours 1compartment NA NA Rat Human -DTXSID5020813 Css NA 1.015 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020813 Css NA 3.549 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020813 Css NA 0.8169 mg/L PBTK NA 50% Rat Human -DTXSID5020813 Css NA 2.256 mg/L PBTK NA 95% Rat Human +DTXSID5020784 Css NA 5.182 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020784 Css NA 26.65 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020784 Css NA 3.271 mg/L PBTK NA 50% Rat Human +DTXSID5020784 Css NA 15.32 mg/L PBTK NA 95% Rat Human +DTXSID5020815 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020815 Fup 0.662 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020815 Vd NA 1.147 L/kg 1compartment NA NA Human Human +DTXSID5020815 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5020815 TK.Half.Life NA 11.92 hours 1compartment NA NA Human Human +DTXSID5020815 Css NA 1.061 mg/L 3compartmentss NA 50% Human Human +DTXSID5020815 Css NA 7.361 mg/L 3compartmentss NA 95% Human Human +DTXSID5020815 Css NA 0.9217 mg/L PBTK NA 50% Human Human +DTXSID5020815 Css NA 4.788 mg/L PBTK NA 95% Human Human +DTXSID5020815 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020815 Fup 0.662 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020815 Vd NA 1.057 L/kg 1compartment NA NA Rat Human +DTXSID5020815 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5020815 TK.Half.Life NA 3.575 hours 1compartment NA NA Rat Human +DTXSID5020815 Css NA 0.06402 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020815 Css NA 0.4093 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020815 Css NA 0.05592 mg/L PBTK NA 50% Rat Human +DTXSID5020815 Css NA 0.2563 mg/L PBTK NA 95% Rat Human +DTXSID50208175 Clint 20 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID50208175 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50208175 Vd NA 0.6734 L/kg 1compartment NA NA Human Human +DTXSID50208175 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50208175 TK.Half.Life NA 1.835 hours 1compartment NA NA Human Human +DTXSID50208175 Css NA 0.3055 mg/L 3compartmentss NA 50% Human Human +DTXSID50208175 Css NA 2.478 mg/L 3compartmentss NA 95% Human Human +DTXSID50208175 Css NA 0.1916 mg/L PBTK NA 50% Human Human +DTXSID50208175 Css NA 1.502 mg/L PBTK NA 95% Human Human +DTXSID50208175 Clint 20 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID50208175 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50208175 Vd NA 0.5441 L/kg 1compartment NA NA Rat Human +DTXSID50208175 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50208175 TK.Half.Life NA 0.8585 hours 1compartment NA NA Rat Human +DTXSID50208175 Css NA 0.03951 mg/L 3compartmentss NA 50% Rat Human +DTXSID50208175 Css NA 0.2566 mg/L 3compartmentss NA 95% Rat Human +DTXSID50208175 Css NA 0.02418 mg/L PBTK NA 50% Rat Human +DTXSID50208175 Css NA 0.1499 mg/L PBTK NA 95% Rat Human DTXSID5020819 Clint 3.924 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5020819 Fup 0.2685 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5020819 Vd NA 1.52 L/kg 1compartment NA NA Human Human DTXSID5020819 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5020819 TK.Half.Life NA 6.769 hours 1compartment NA NA Human Human -DTXSID5020819 Css NA 0.4528 mg/L 3compartmentss NA 50% Human Human -DTXSID5020819 Css NA 2.436 mg/L 3compartmentss NA 95% Human Human -DTXSID5020819 Css NA 0.3388 mg/L PBTK NA 50% Human Human -DTXSID5020819 Css NA 1.645 mg/L PBTK NA 95% Human Human +DTXSID5020819 Css NA 0.4392 mg/L 3compartmentss NA 50% Human Human +DTXSID5020819 Css NA 2.424 mg/L 3compartmentss NA 95% Human Human +DTXSID5020819 Css NA 0.33 mg/L PBTK NA 50% Human Human +DTXSID5020819 Css NA 1.618 mg/L PBTK NA 95% Human Human DTXSID5020819 Clint 3.924 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID5020819 Fup 0.2685 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID5020819 Vd NA 1.219 L/kg 1compartment NA NA Rat Human DTXSID5020819 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020819 TK.Half.Life NA 2.648 hours 1compartment NA NA Rat Human -DTXSID5020819 Css NA 0.2245 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020819 Css NA 0.8424 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020819 Css NA 0.1607 mg/L PBTK NA 50% Rat Human -DTXSID5020819 Css NA 0.5316 mg/L PBTK NA 95% Rat Human -DTXSID5020861 Clint NA 12.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020861 Fup NA 0.671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020861 Vd NA 1.333 L/kg 1compartment NA NA Human Human +DTXSID5020819 Css NA 0.04958 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020819 Css NA 0.1976 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020819 Css NA 0.03708 mg/L PBTK NA 50% Rat Human +DTXSID5020819 Css NA 0.1286 mg/L PBTK NA 95% Rat Human +DTXSID5020861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020861 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020861 Vd NA 1.032 L/kg 1compartment NA NA Human Human DTXSID5020861 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020861 TK.Half.Life NA 1.363 hours 1compartment NA NA Human Human -DTXSID5020861 Css NA 0.05512 mg/L 3compartmentss NA 50% Human Human -DTXSID5020861 Css NA 0.5633 mg/L 3compartmentss NA 95% Human Human -DTXSID5020861 Css NA 0.04803 mg/L PBTK NA 50% Human Human -DTXSID5020861 Css NA 0.4022 mg/L PBTK NA 95% Human Human -DTXSID5020861 Clint NA 12.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020861 Fup NA 0.671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020861 Vd NA 1.191 L/kg 1compartment NA NA Rat Human +DTXSID5020861 TK.Half.Life NA 1.096 hours 1compartment NA NA Human Human +DTXSID5020861 Css NA 0.04472 mg/L 3compartmentss NA 50% Human Human +DTXSID5020861 Css NA 0.3604 mg/L 3compartmentss NA 95% Human Human +DTXSID5020861 Css NA 0.0354 mg/L PBTK NA 50% Human Human +DTXSID5020861 Css NA 0.2509 mg/L PBTK NA 95% Human Human +DTXSID5020861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020861 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020861 Vd NA 0.9192 L/kg 1compartment NA NA Rat Human DTXSID5020861 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020861 TK.Half.Life NA 0.6091 hours 1compartment NA NA Rat Human -DTXSID5020861 Css NA 0.02746 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020861 Css NA 0.2198 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020861 Css NA 0.02358 mg/L PBTK NA 50% Rat Human -DTXSID5020861 Css NA 0.1475 mg/L PBTK NA 95% Rat Human -DTXSID5020863 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020863 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020863 Vd NA 0.6632 L/kg 1compartment NA NA Human Human +DTXSID5020861 TK.Half.Life NA 0.4923 hours 1compartment NA NA Rat Human +DTXSID5020861 Css NA 0.005486 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020861 Css NA 0.03672 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020861 Css NA 0.004354 mg/L PBTK NA 50% Rat Human +DTXSID5020861 Css NA 0.02553 mg/L PBTK NA 95% Rat Human +DTXSID5020863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020863 Fup 0.69 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020863 Vd NA 0.5168 L/kg 1compartment NA NA Human Human DTXSID5020863 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020863 TK.Half.Life NA 4.292 hours 1compartment NA NA Human Human -DTXSID5020863 Css NA 0.8689 mg/L 3compartmentss NA 50% Human Human -DTXSID5020863 Css NA 5.576 mg/L 3compartmentss NA 95% Human Human -DTXSID5020863 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID5020863 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID5020863 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020863 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020863 Vd NA 0.7001 L/kg 1compartment NA NA Rat Human +DTXSID5020863 TK.Half.Life NA 4.844 hours 1compartment NA NA Human Human +DTXSID5020863 Css NA 0.6378 mg/L 3compartmentss NA 50% Human Human +DTXSID5020863 Css NA 4.183 mg/L 3compartmentss NA 95% Human Human +DTXSID5020863 Css NA 0.4845 mg/L PBTK NA 50% Human Human +DTXSID5020863 Css NA 2.625 mg/L PBTK NA 95% Human Human +DTXSID5020863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020863 Fup 0.69 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020863 Vd NA 0.5486 L/kg 1compartment NA NA Rat Human DTXSID5020863 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020863 TK.Half.Life NA 1.543 hours 1compartment NA NA Rat Human -DTXSID5020863 Css NA 0.219 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020863 Css NA 1.349 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020863 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID5020863 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5020865 Clint NA 144.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020865 Fup NA 0.043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020865 Vd NA 2.556 L/kg 1compartment NA NA Human Human -DTXSID5020865 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020865 TK.Half.Life NA 4.99 hours 1compartment NA NA Human Human -DTXSID5020865 Css NA 0.1625 mg/L 3compartmentss NA 50% Human Human -DTXSID5020865 Css NA 1.139 mg/L 3compartmentss NA 95% Human Human -DTXSID5020865 Css NA 0.1095 mg/L PBTK NA 50% Human Human -DTXSID5020865 Css NA 0.7373 mg/L PBTK NA 95% Human Human -DTXSID5020865 Clint NA 144.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020865 Fup NA 0.043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020865 Vd NA 1.913 L/kg 1compartment NA NA Rat Human -DTXSID5020865 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020865 TK.Half.Life NA 1.373 hours 1compartment NA NA Rat Human -DTXSID5020865 Css NA 0.092 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020865 Css NA 0.5176 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020865 Css NA 0.05868 mg/L PBTK NA 50% Rat Human -DTXSID5020865 Css NA 0.3215 mg/L PBTK NA 95% Rat Human +DTXSID5020863 TK.Half.Life NA 1.753 hours 1compartment NA NA Rat Human +DTXSID5020863 Css NA 0.003388 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020863 Css NA 0.02254 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020863 Css NA 0.00247 mg/L PBTK NA 50% Rat Human +DTXSID5020863 Css NA 0.01354 mg/L PBTK NA 95% Rat Human +DTXSID5020865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020865 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020865 Vd NA 2.03 L/kg 1compartment NA NA Human Human +DTXSID5020865 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5020865 TK.Half.Life NA 23.1 hours 1compartment NA NA Human Human +DTXSID5020865 Css NA 1.693 mg/L 3compartmentss NA 50% Human Human +DTXSID5020865 Css NA 14.13 mg/L 3compartmentss NA 95% Human Human +DTXSID5020865 Css NA 1.087 mg/L PBTK NA 50% Human Human +DTXSID5020865 Css NA 8.762 mg/L PBTK NA 95% Human Human +DTXSID5020865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020865 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020865 Vd NA 1.508 L/kg 1compartment NA NA Rat Human +DTXSID5020865 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5020865 TK.Half.Life NA 7.325 hours 1compartment NA NA Rat Human +DTXSID5020865 Css NA 0.2207 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020865 Css NA 1.516 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020865 Css NA 0.1386 mg/L PBTK NA 50% Rat Human +DTXSID5020865 Css NA 0.9231 mg/L PBTK NA 95% Rat Human DTXSID5020867 Clint 3.984 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5020867 Fup 0.2257 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5020867 Vd NA 1.387 L/kg 1compartment NA NA Human Human +DTXSID5020867 Vd NA 1.352 L/kg 1compartment NA NA Human Human DTXSID5020867 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020867 TK.Half.Life NA 6.849 hours 1compartment NA NA Human Human -DTXSID5020867 Css NA 0.5179 mg/L 3compartmentss NA 50% Human Human -DTXSID5020867 Css NA 2.756 mg/L 3compartmentss NA 95% Human Human -DTXSID5020867 Css NA 0.378 mg/L PBTK NA 50% Human Human -DTXSID5020867 Css NA 1.829 mg/L PBTK NA 95% Human Human +DTXSID5020867 TK.Half.Life NA 6.614 hours 1compartment NA NA Human Human +DTXSID5020867 Css NA 0.5015 mg/L 3compartmentss NA 50% Human Human +DTXSID5020867 Css NA 2.795 mg/L 3compartmentss NA 95% Human Human +DTXSID5020867 Css NA 0.3632 mg/L PBTK NA 50% Human Human +DTXSID5020867 Css NA 1.863 mg/L PBTK NA 95% Human Human DTXSID5020867 Clint 3.984 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5020867 Fup 0.2257 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5020867 Vd NA 1.117 L/kg 1compartment NA NA Rat Human +DTXSID5020867 Vd NA 1.092 L/kg 1compartment NA NA Rat Human DTXSID5020867 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020867 TK.Half.Life NA 2.792 hours 1compartment NA NA Rat Human -DTXSID5020867 Css NA 0.2583 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020867 Css NA 1.003 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020867 Css NA 0.1805 mg/L PBTK NA 50% Rat Human -DTXSID5020867 Css NA 0.6132 mg/L PBTK NA 95% Rat Human +DTXSID5020867 TK.Half.Life NA 2.726 hours 1compartment NA NA Rat Human +DTXSID5020867 Css NA 0.05746 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020867 Css NA 0.2217 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020867 Css NA 0.04162 mg/L PBTK NA 50% Rat Human +DTXSID5020867 Css NA 0.1438 mg/L PBTK NA 95% Rat Human DTXSID5020869 Clint 18.85 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5020869 Fup 0.001109 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5020869 Vd NA 0.5075 L/kg 1compartment NA NA Human Human -DTXSID5020869 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID5020869 TK.Half.Life NA 55.23 hours 1compartment NA NA Human Human -DTXSID5020869 Css NA 20.74 mg/L 3compartmentss NA 50% Human Human -DTXSID5020869 Css NA 187.4 mg/L 3compartmentss NA 95% Human Human -DTXSID5020869 Css NA 12.1 mg/L PBTK NA 50% Human Human -DTXSID5020869 Css NA 106.4 mg/L PBTK NA 95% Human Human +DTXSID5020869 Vd NA 0.397 L/kg 1compartment NA NA Human Human +DTXSID5020869 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID5020869 TK.Half.Life NA 48.71 hours 1compartment NA NA Human Human +DTXSID5020869 Css NA 22.76 mg/L 3compartmentss NA 50% Human Human +DTXSID5020869 Css NA 206.7 mg/L 3compartmentss NA 95% Human Human +DTXSID5020869 Css NA 13.23 mg/L PBTK NA 50% Human Human +DTXSID5020869 Css NA 120.2 mg/L PBTK NA 95% Human Human DTXSID5020869 Clint 18.85 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5020869 Fup 0.001109 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5020869 Vd NA 0.3799 L/kg 1compartment NA NA Rat Human -DTXSID5020869 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5020869 TK.Half.Life NA 27.45 hours 1compartment NA NA Rat Human -DTXSID5020869 Css NA 11.93 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020869 Css NA 82.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020869 Css NA 6.519 mg/L PBTK NA 50% Rat Human -DTXSID5020869 Css NA 44.67 mg/L PBTK NA 95% Rat Human +DTXSID5020869 Vd NA 0.3049 L/kg 1compartment NA NA Rat Human +DTXSID5020869 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5020869 TK.Half.Life NA 25.15 hours 1compartment NA NA Rat Human +DTXSID5020869 Css NA 3.004 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020869 Css NA 21.43 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020869 Css NA 1.69 mg/L PBTK NA 50% Rat Human +DTXSID5020869 Css NA 12.01 mg/L PBTK NA 95% Rat Human DTXSID5020944 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020944 Fup 0.856 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5020944 Vd NA 0.5425 L/kg 1compartment NA NA Human Human DTXSID5020944 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5020944 TK.Half.Life NA 4.104 hours 1compartment NA NA Human Human -DTXSID5020944 Css NA 0.9192 mg/L 3compartmentss NA 50% Human Human -DTXSID5020944 Css NA 2.721 mg/L 3compartmentss NA 95% Human Human -DTXSID5020944 Css NA 0.7124 mg/L PBTK NA 50% Human Human -DTXSID5020944 Css NA 1.869 mg/L PBTK NA 95% Human Human +DTXSID5020944 Css NA 0.8974 mg/L 3compartmentss NA 50% Human Human +DTXSID5020944 Css NA 2.636 mg/L 3compartmentss NA 95% Human Human +DTXSID5020944 Css NA 0.694 mg/L PBTK NA 50% Human Human +DTXSID5020944 Css NA 1.813 mg/L PBTK NA 95% Human Human DTXSID5020944 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020944 Fup 0.856 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5020944 Vd NA 0.5565 L/kg 1compartment NA NA Rat Human DTXSID5020944 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5020944 TK.Half.Life NA 1.434 hours 1compartment NA NA Rat Human -DTXSID5020944 Css NA 0.2425 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020944 Css NA 0.5872 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020944 Css NA 0.1817 mg/L PBTK NA 50% Rat Human -DTXSID5020944 Css NA 0.3763 mg/L PBTK NA 95% Rat Human -DTXSID5020946 Clint NA 8.615 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020946 Fup NA 0.3554 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020946 Vd NA 0.7698 L/kg 1compartment NA NA Human Human +DTXSID5020944 Css NA 0.05439 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020944 Css NA 0.1327 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020944 Css NA 0.04228 mg/L PBTK NA 50% Rat Human +DTXSID5020944 Css NA 0.08814 mg/L PBTK NA 95% Rat Human +DTXSID5020946 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020946 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020946 Vd NA 0.7937 L/kg 1compartment NA NA Human Human DTXSID5020946 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5020946 TK.Half.Life NA 1.42 hours 1compartment NA NA Human Human -DTXSID5020946 Css NA 0.1422 mg/L 3compartmentss NA 50% Human Human -DTXSID5020946 Css NA 0.9766 mg/L 3compartmentss NA 95% Human Human -DTXSID5020946 Css NA 0.1074 mg/L PBTK NA 50% Human Human -DTXSID5020946 Css NA 0.6543 mg/L PBTK NA 95% Human Human -DTXSID5020946 Clint NA 8.615 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020946 Fup NA 0.3554 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020946 Vd NA 0.7103 L/kg 1compartment NA NA Rat Human +DTXSID5020946 TK.Half.Life NA 0.9147 hours 1compartment NA NA Human Human +DTXSID5020946 Css NA 0.0519 mg/L 3compartmentss NA 50% Human Human +DTXSID5020946 Css NA 0.4089 mg/L 3compartmentss NA 95% Human Human +DTXSID5020946 Css NA 0.03894 mg/L PBTK NA 50% Human Human +DTXSID5020946 Css NA 0.2755 mg/L PBTK NA 95% Human Human +DTXSID5020946 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020946 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020946 Vd NA 0.7327 L/kg 1compartment NA NA Rat Human DTXSID5020946 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020946 TK.Half.Life NA 0.7235 hours 1compartment NA NA Rat Human -DTXSID5020946 Css NA 0.07278 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020946 Css NA 0.3779 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020946 Css NA 0.05204 mg/L PBTK NA 50% Rat Human -DTXSID5020946 Css NA 0.2383 mg/L PBTK NA 95% Rat Human -DTXSID5020948 Clint NA 0.007143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020948 Fup NA 0.2234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5020948 Vd NA 0.4365 L/kg 1compartment NA NA Human Human -DTXSID5020948 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5020948 TK.Half.Life NA 12.49 hours 1compartment NA NA Human Human -DTXSID5020948 Css NA 3.394 mg/L 3compartmentss NA 50% Human Human -DTXSID5020948 Css NA 13.23 mg/L 3compartmentss NA 95% Human Human -DTXSID5020948 Css NA 2.326 mg/L PBTK NA 50% Human Human -DTXSID5020948 Css NA 8.091 mg/L PBTK NA 95% Human Human -DTXSID5020948 Clint NA 0.007143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020948 Fup NA 0.2234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5020948 Vd NA 0.4404 L/kg 1compartment NA NA Rat Human +DTXSID5020946 TK.Half.Life NA 0.4357 hours 1compartment NA NA Rat Human +DTXSID5020946 Css NA 0.006403 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020946 Css NA 0.04059 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020946 Css NA 0.004841 mg/L PBTK NA 50% Rat Human +DTXSID5020946 Css NA 0.02736 mg/L PBTK NA 95% Rat Human +DTXSID5020948 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020948 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5020948 Vd NA 0.452 L/kg 1compartment NA NA Human Human +DTXSID5020948 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5020948 TK.Half.Life NA 0.6671 hours 1compartment NA NA Human Human +DTXSID5020948 Css NA 0.08529 mg/L 3compartmentss NA 50% Human Human +DTXSID5020948 Css NA 0.6209 mg/L 3compartmentss NA 95% Human Human +DTXSID5020948 Css NA 0.0586 mg/L PBTK NA 50% Human Human +DTXSID5020948 Css NA 0.4072 mg/L PBTK NA 95% Human Human +DTXSID5020948 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020948 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5020948 Vd NA 0.4566 L/kg 1compartment NA NA Rat Human DTXSID5020948 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5020948 TK.Half.Life NA 4.321 hours 1compartment NA NA Rat Human -DTXSID5020948 Css NA 0.9546 mg/L 3compartmentss NA 50% Rat Human -DTXSID5020948 Css NA 3.059 mg/L 3compartmentss NA 95% Rat Human -DTXSID5020948 Css NA 0.6181 mg/L PBTK NA 50% Rat Human -DTXSID5020948 Css NA 1.766 mg/L PBTK NA 95% Rat Human -DTXSID5021093 Clint NA 22.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021093 Fup NA 0.4569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021093 Vd NA 3.355 L/kg 1compartment NA NA Human Human +DTXSID5020948 TK.Half.Life NA 0.366 hours 1compartment NA NA Rat Human +DTXSID5020948 Css NA 0.01084 mg/L 3compartmentss NA 50% Rat Human +DTXSID5020948 Css NA 0.06008 mg/L 3compartmentss NA 95% Rat Human +DTXSID5020948 Css NA 0.007384 mg/L PBTK NA 50% Rat Human +DTXSID5020948 Css NA 0.03798 mg/L PBTK NA 95% Rat Human +DTXSID5021093 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021093 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021093 Vd NA 3.22 L/kg 1compartment NA NA Human Human DTXSID5021093 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021093 TK.Half.Life NA 2.51 hours 1compartment NA NA Human Human -DTXSID5021093 Css NA 0.02562 mg/L 3compartmentss NA 50% Human Human -DTXSID5021093 Css NA 0.2614 mg/L 3compartmentss NA 95% Human Human -DTXSID5021093 Css NA 0.03172 mg/L PBTK NA 50% Human Human -DTXSID5021093 Css NA 0.243 mg/L PBTK NA 95% Human Human -DTXSID5021093 Clint NA 22.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021093 Fup NA 0.4569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021093 Vd NA 3.394 L/kg 1compartment NA NA Rat Human +DTXSID5021093 TK.Half.Life NA 5.267 hours 1compartment NA NA Human Human +DTXSID5021093 Css NA 0.09066 mg/L 3compartmentss NA 50% Human Human +DTXSID5021093 Css NA 0.7652 mg/L 3compartmentss NA 95% Human Human +DTXSID5021093 Css NA 0.1076 mg/L PBTK NA 50% Human Human +DTXSID5021093 Css NA 0.6728 mg/L PBTK NA 95% Human Human +DTXSID5021093 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021093 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021093 Vd NA 3.254 L/kg 1compartment NA NA Rat Human DTXSID5021093 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021093 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Human -DTXSID5021093 Css NA 0.01336 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021093 Css NA 0.1068 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021093 Css NA 0.0163 mg/L PBTK NA 50% Rat Human -DTXSID5021093 Css NA 0.09119 mg/L PBTK NA 95% Rat Human +DTXSID5021093 TK.Half.Life NA 3.1 hours 1compartment NA NA Rat Human +DTXSID5021093 Css NA 0.01018 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021093 Css NA 0.06727 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021093 Css NA 0.01271 mg/L PBTK NA 50% Rat Human +DTXSID5021093 Css NA 0.05587 mg/L PBTK NA 95% Rat Human DTXSID5021097 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5021097 Fup 0.6283 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5021097 Vd NA 0.4689 L/kg 1compartment NA NA Human Human +DTXSID5021097 Vd NA 0.4664 L/kg 1compartment NA NA Human Human DTXSID5021097 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021097 TK.Half.Life NA 4.83 hours 1compartment NA NA Human Human -DTXSID5021097 Css NA 1.298 mg/L 3compartmentss NA 50% Human Human -DTXSID5021097 Css NA 8.196 mg/L 3compartmentss NA 95% Human Human -DTXSID5021097 Css NA 0.9577 mg/L PBTK NA 50% Human Human -DTXSID5021097 Css NA 4.993 mg/L PBTK NA 95% Human Human +DTXSID5021097 TK.Half.Life NA 4.804 hours 1compartment NA NA Human Human +DTXSID5021097 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human +DTXSID5021097 Css NA 6.87 mg/L 3compartmentss NA 95% Human Human +DTXSID5021097 Css NA 0.8148 mg/L PBTK NA 50% Human Human +DTXSID5021097 Css NA 4.265 mg/L PBTK NA 95% Human Human DTXSID5021097 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5021097 Fup 0.6283 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5021097 Vd NA 0.4892 L/kg 1compartment NA NA Rat Human +DTXSID5021097 Vd NA 0.4871 L/kg 1compartment NA NA Rat Human DTXSID5021097 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021097 TK.Half.Life NA 1.717 hours 1compartment NA NA Rat Human -DTXSID5021097 Css NA 0.3465 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021097 Css NA 1.997 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021097 Css NA 0.2416 mg/L PBTK NA 50% Rat Human -DTXSID5021097 Css NA 1.145 mg/L PBTK NA 95% Rat Human +DTXSID5021097 TK.Half.Life NA 1.709 hours 1compartment NA NA Rat Human +DTXSID5021097 Css NA 0.0212 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021097 Css NA 0.1704 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021097 Css NA 0.01481 mg/L PBTK NA 50% Rat Human +DTXSID5021097 Css NA 0.1037 mg/L PBTK NA 95% Rat Human +DTXSID5021120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021120 Fup 0.0682 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021120 Vd NA 2.29 L/kg 1compartment NA NA Human Human +DTXSID5021120 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5021120 TK.Half.Life NA 11.45 hours 1compartment NA NA Human Human +DTXSID5021120 Css NA 0.5932 mg/L 3compartmentss NA 50% Human Human +DTXSID5021120 Css NA 3.835 mg/L 3compartmentss NA 95% Human Human +DTXSID5021120 Css NA 0.3978 mg/L PBTK NA 50% Human Human +DTXSID5021120 Css NA 2.478 mg/L PBTK NA 95% Human Human +DTXSID5021120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021120 Fup 0.0682 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021120 Vd NA 1.72 L/kg 1compartment NA NA Rat Human +DTXSID5021120 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5021120 TK.Half.Life NA 3.31 hours 1compartment NA NA Rat Human +DTXSID5021120 Css NA 0.07521 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021120 Css NA 0.405 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021120 Css NA 0.04994 mg/L PBTK NA 50% Rat Human +DTXSID5021120 Css NA 0.2632 mg/L PBTK NA 95% Rat Human DTXSID5021122 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID5021122 Fup 0.49 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5021122 Vd NA 0.8143 L/kg 1compartment NA NA Human Human DTXSID5021122 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID5021122 TK.Half.Life NA 11.51 hours 1compartment NA NA Human Human -DTXSID5021122 Css NA 1.432 mg/L 3compartmentss NA 50% Human Human -DTXSID5021122 Css NA 7.339 mg/L 3compartmentss NA 95% Human Human -DTXSID5021122 Css NA 1.202 mg/L PBTK NA 50% Human Human -DTXSID5021122 Css NA 4.876 mg/L PBTK NA 95% Human Human +DTXSID5021122 Css NA 1.343 mg/L 3compartmentss NA 50% Human Human +DTXSID5021122 Css NA 5.553 mg/L 3compartmentss NA 95% Human Human +DTXSID5021122 Css NA 1.155 mg/L PBTK NA 50% Human Human +DTXSID5021122 Css NA 4.776 mg/L PBTK NA 95% Human Human DTXSID5021122 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID5021122 Fup 0.49 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5021122 Vd NA 0.7894 L/kg 1compartment NA NA Rat Human DTXSID5021122 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021122 TK.Half.Life NA 2.779 hours 1compartment NA NA Rat Human -DTXSID5021122 Css NA 0.3159 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021122 Css NA 1.875 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021122 Css NA 0.252 mg/L PBTK NA 50% Rat Human -DTXSID5021122 Css NA 1.121 mg/L PBTK NA 95% Rat Human +DTXSID5021122 Css NA 0.06617 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021122 Css NA 0.2904 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021122 Css NA 0.05894 mg/L PBTK NA 50% Rat Human +DTXSID5021122 Css NA 0.2587 mg/L PBTK NA 95% Rat Human DTXSID5021124 Clint 5.496 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5021124 Fup 0.6201 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5021124 Vd NA 1.527 L/kg 1compartment NA NA Human Human DTXSID5021124 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021124 TK.Half.Life NA 2.414 hours 1compartment NA NA Human Human -DTXSID5021124 Css NA 0.1166 mg/L 3compartmentss NA 50% Human Human -DTXSID5021124 Css NA 1.038 mg/L 3compartmentss NA 95% Human Human -DTXSID5021124 Css NA 0.1094 mg/L PBTK NA 50% Human Human -DTXSID5021124 Css NA 0.7436 mg/L PBTK NA 95% Human Human +DTXSID5021124 Css NA 0.09432 mg/L 3compartmentss NA 50% Human Human +DTXSID5021124 Css NA 0.9436 mg/L 3compartmentss NA 95% Human Human +DTXSID5021124 Css NA 0.08903 mg/L PBTK NA 50% Human Human +DTXSID5021124 Css NA 0.6751 mg/L PBTK NA 95% Human Human DTXSID5021124 Clint 5.496 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5021124 Fup 0.6201 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5021124 Vd NA 1.381 L/kg 1compartment NA NA Rat Human DTXSID5021124 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021124 TK.Half.Life NA 1.13 hours 1compartment NA NA Rat Human -DTXSID5021124 Css NA 0.05595 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021124 Css NA 0.4526 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021124 Css NA 0.05116 mg/L PBTK NA 50% Rat Human -DTXSID5021124 Css NA 0.2918 mg/L PBTK NA 95% Rat Human +DTXSID5021124 Css NA 0.003162 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021124 Css NA 0.03288 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021124 Css NA 0.002944 mg/L PBTK NA 50% Rat Human +DTXSID5021124 Css NA 0.02378 mg/L PBTK NA 95% Rat Human DTXSID5021126 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021126 Fup 0.0043 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021126 Vd NA 1.467 L/kg 1compartment NA NA Human Human -DTXSID5021126 Days.Css NA 855 Days PBTK NA NA Human Human +DTXSID5021126 Days.Css NA 856 Days PBTK NA NA Human Human DTXSID5021126 TK.Half.Life NA 3162 hours 1compartment NA NA Human Human -DTXSID5021126 Css NA 212.9 mg/L 3compartmentss NA 50% Human Human -DTXSID5021126 Css NA 737.4 mg/L 3compartmentss NA 95% Human Human -DTXSID5021126 Css NA 134.9 mg/L PBTK NA 50% Human Human -DTXSID5021126 Css NA 439.7 mg/L PBTK NA 95% Human Human +DTXSID5021126 Css NA 206.5 mg/L 3compartmentss NA 50% Human Human +DTXSID5021126 Css NA 709.9 mg/L 3compartmentss NA 95% Human Human +DTXSID5021126 Css NA 131 mg/L PBTK NA 50% Human Human +DTXSID5021126 Css NA 424.4 mg/L PBTK NA 95% Human Human DTXSID5021126 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5021126 Fup 0.0043 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5021126 Vd NA 1.078 L/kg 1compartment NA NA Rat Human -DTXSID5021126 Days.Css NA 208 Days PBTK NA NA Rat Human +DTXSID5021126 Days.Css NA 209 Days PBTK NA NA Rat Human DTXSID5021126 TK.Half.Life NA 610.2 hours 1compartment NA NA Rat Human -DTXSID5021126 Css NA 59.19 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021126 Css NA 171.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021126 Css NA 35.24 mg/L PBTK NA 50% Rat Human -DTXSID5021126 Css NA 96.26 mg/L PBTK NA 95% Rat Human -DTXSID5021170 Clint NA 0.7822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021170 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021170 Vd NA 0.2365 L/kg 1compartment NA NA Human Human -DTXSID5021170 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5021170 TK.Half.Life NA 18.54 hours 1compartment NA NA Human Human -DTXSID5021170 Css NA 14.02 mg/L 3compartmentss NA 50% Human Human -DTXSID5021170 Css NA 71.19 mg/L 3compartmentss NA 95% Human Human -DTXSID5021170 Css NA 8.413 mg/L PBTK NA 50% Human Human -DTXSID5021170 Css NA 41.38 mg/L PBTK NA 95% Human Human -DTXSID5021170 Clint NA 0.7822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021170 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021170 Vd NA 0.2311 L/kg 1compartment NA NA Rat Human +DTXSID5021126 Css NA 13.33 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021126 Css NA 37.51 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021126 Css NA 8.222 mg/L PBTK NA 50% Rat Human +DTXSID5021126 Css NA 21.79 mg/L PBTK NA 95% Rat Human +DTXSID5021128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021128 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021128 Vd NA 2.146 L/kg 1compartment NA NA Human Human +DTXSID5021128 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5021128 TK.Half.Life NA 3.448 hours 1compartment NA NA Human Human +DTXSID5021128 Css NA 0.1014 mg/L 3compartmentss NA 50% Human Human +DTXSID5021128 Css NA 0.7107 mg/L 3compartmentss NA 95% Human Human +DTXSID5021128 Css NA 0.07778 mg/L PBTK NA 50% Human Human +DTXSID5021128 Css NA 0.4931 mg/L PBTK NA 95% Human Human +DTXSID5021128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021128 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021128 Vd NA 1.674 L/kg 1compartment NA NA Rat Human +DTXSID5021128 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5021128 TK.Half.Life NA 1.15 hours 1compartment NA NA Rat Human +DTXSID5021128 Css NA 0.01285 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021128 Css NA 0.06855 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021128 Css NA 0.009802 mg/L PBTK NA 50% Rat Human +DTXSID5021128 Css NA 0.04817 mg/L PBTK NA 95% Rat Human +DTXSID5021170 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021170 Fup 0.0822 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021170 Vd NA 0.3142 L/kg 1compartment NA NA Human Human +DTXSID5021170 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5021170 TK.Half.Life NA 2.415 hours 1compartment NA NA Human Human +DTXSID5021170 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human +DTXSID5021170 Css NA 8.107 mg/L 3compartmentss NA 95% Human Human +DTXSID5021170 Css NA 0.7095 mg/L PBTK NA 50% Human Human +DTXSID5021170 Css NA 4.816 mg/L PBTK NA 95% Human Human +DTXSID5021170 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021170 Fup 0.0822 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021170 Vd NA 0.3076 L/kg 1compartment NA NA Rat Human DTXSID5021170 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021170 TK.Half.Life NA 8.682 hours 1compartment NA NA Rat Human -DTXSID5021170 Css NA 5.634 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021170 Css NA 23.98 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021170 Css NA 3.15 mg/L PBTK NA 50% Rat Human -DTXSID5021170 Css NA 13.05 mg/L PBTK NA 95% Rat Human -DTXSID5021174 Clint NA 0.266 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021174 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021174 Vd NA 49.61 L/kg 1compartment NA NA Human Human -DTXSID5021174 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID5021174 TK.Half.Life NA 113200 hours 1compartment NA NA Human Human -DTXSID5021174 Css NA 33.88 mg/L 3compartmentss NA 50% Human Human -DTXSID5021174 Css NA 181.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5021174 Css NA 185.2 mg/L PBTK NA 50% Human Human -DTXSID5021174 Css NA 901.4 mg/L PBTK NA 95% Human Human -DTXSID5021174 Clint NA 0.266 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021174 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021174 Vd NA 41.81 L/kg 1compartment NA NA Rat Human -DTXSID5021174 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID5021174 TK.Half.Life NA 15580 hours 1compartment NA NA Rat Human -DTXSID5021174 Css NA 16.69 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021174 Css NA 54.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021174 Css NA 96.4 mg/L PBTK NA 50% Rat Human -DTXSID5021174 Css NA 314.4 mg/L PBTK NA 95% Rat Human +DTXSID5021170 TK.Half.Life NA 1.455 hours 1compartment NA NA Rat Human +DTXSID5021170 Css NA 0.1412 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021170 Css NA 0.7066 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021170 Css NA 0.08555 mg/L PBTK NA 50% Rat Human +DTXSID5021170 Css NA 0.4104 mg/L PBTK NA 95% Rat Human DTXSID5021201 Clint 49.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021201 Fup 0.0258 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021201 Vd NA 0.2397 L/kg 1compartment NA NA Human Human DTXSID5021201 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021201 TK.Half.Life NA 0.9334 hours 1compartment NA NA Human Human -DTXSID5021201 Css NA 0.376 mg/L 3compartmentss NA 50% Human Human -DTXSID5021201 Css NA 2.327 mg/L 3compartmentss NA 95% Human Human -DTXSID5021201 Css NA 0.2224 mg/L PBTK NA 50% Human Human -DTXSID5021201 Css NA 1.37 mg/L PBTK NA 95% Human Human +DTXSID5021201 Css NA 0.3566 mg/L 3compartmentss NA 50% Human Human +DTXSID5021201 Css NA 2.421 mg/L 3compartmentss NA 95% Human Human +DTXSID5021201 Css NA 0.2108 mg/L PBTK NA 50% Human Human +DTXSID5021201 Css NA 1.447 mg/L PBTK NA 95% Human Human DTXSID5021201 Clint 49.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5021201 Fup 0.0258 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5021201 Vd NA 0.2184 L/kg 1compartment NA NA Rat Human DTXSID5021201 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021201 TK.Half.Life NA 0.534 hours 1compartment NA NA Rat Human -DTXSID5021201 Css NA 0.213 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021201 Css NA 1.095 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021201 Css NA 0.1179 mg/L PBTK NA 50% Rat Human -DTXSID5021201 Css NA 0.6005 mg/L PBTK NA 95% Rat Human +DTXSID5021201 Css NA 0.04187 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021201 Css NA 0.2206 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021201 Css NA 0.02398 mg/L PBTK NA 50% Rat Human +DTXSID5021201 Css NA 0.1249 mg/L PBTK NA 95% Rat Human DTXSID5021209 Clint 1.323 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5021209 Fup 0.4736 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5021209 Vd NA 0.5501 L/kg 1compartment NA NA Human Human +DTXSID5021209 Vd NA 0.6683 L/kg 1compartment NA NA Human Human DTXSID5021209 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021209 TK.Half.Life NA 2.547 hours 1compartment NA NA Human Human -DTXSID5021209 Css NA 0.4931 mg/L 3compartmentss NA 50% Human Human -DTXSID5021209 Css NA 2.767 mg/L 3compartmentss NA 95% Human Human -DTXSID5021209 Css NA 0.3685 mg/L PBTK NA 50% Human Human -DTXSID5021209 Css NA 1.758 mg/L PBTK NA 95% Human Human +DTXSID5021209 TK.Half.Life NA 3.099 hours 1compartment NA NA Human Human +DTXSID5021209 Css NA 0.4654 mg/L 3compartmentss NA 50% Human Human +DTXSID5021209 Css NA 2.708 mg/L 3compartmentss NA 95% Human Human +DTXSID5021209 Css NA 0.3576 mg/L PBTK NA 50% Human Human +DTXSID5021209 Css NA 1.765 mg/L PBTK NA 95% Human Human DTXSID5021209 Clint 1.323 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5021209 Fup 0.4736 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5021209 Vd NA 0.5637 L/kg 1compartment NA NA Rat Human +DTXSID5021209 Vd NA 0.659 L/kg 1compartment NA NA Rat Human DTXSID5021209 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021209 TK.Half.Life NA 1.32 hours 1compartment NA NA Rat Human -DTXSID5021209 Css NA 0.2056 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021209 Css NA 0.9594 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021209 Css NA 0.148 mg/L PBTK NA 50% Rat Human -DTXSID5021209 Css NA 0.5678 mg/L PBTK NA 95% Rat Human +DTXSID5021209 TK.Half.Life NA 1.541 hours 1compartment NA NA Rat Human +DTXSID5021209 Css NA 0.04464 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021209 Css NA 0.2144 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021209 Css NA 0.03415 mg/L PBTK NA 50% Rat Human +DTXSID5021209 Css NA 0.134 mg/L PBTK NA 95% Rat Human DTXSID5021251 Clint 1.917 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID5021251 Fup 0.2258 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID5021251 Vd NA 0.3082 L/kg 1compartment NA NA Human Human +DTXSID5021251 Vd NA 0.4246 L/kg 1compartment NA NA Human Human DTXSID5021251 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021251 TK.Half.Life NA 2.267 hours 1compartment NA NA Human Human -DTXSID5021251 Css NA 0.8844 mg/L 3compartmentss NA 50% Human Human -DTXSID5021251 Css NA 3.382 mg/L 3compartmentss NA 95% Human Human -DTXSID5021251 Css NA 0.57 mg/L PBTK NA 50% Human Human -DTXSID5021251 Css NA 2.107 mg/L PBTK NA 95% Human Human +DTXSID5021251 TK.Half.Life NA 3.056 hours 1compartment NA NA Human Human +DTXSID5021251 Css NA 0.8078 mg/L 3compartmentss NA 50% Human Human +DTXSID5021251 Css NA 3.211 mg/L 3compartmentss NA 95% Human Human +DTXSID5021251 Css NA 0.5484 mg/L PBTK NA 50% Human Human +DTXSID5021251 Css NA 2.069 mg/L PBTK NA 95% Human Human DTXSID5021251 Clint 1.917 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID5021251 Fup 0.2258 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID5021251 Vd NA 0.31 L/kg 1compartment NA NA Rat Human +DTXSID5021251 Vd NA 0.43 L/kg 1compartment NA NA Rat Human DTXSID5021251 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021251 TK.Half.Life NA 1.234 hours 1compartment NA NA Rat Human -DTXSID5021251 Css NA 0.4042 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021251 Css NA 1.083 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021251 Css NA 0.247 mg/L PBTK NA 50% Rat Human -DTXSID5021251 Css NA 0.6277 mg/L PBTK NA 95% Rat Human -DTXSID5021253 Clint NA 0.05249 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021253 Fup NA 0.2638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021253 Vd NA 0.3287 L/kg 1compartment NA NA Human Human +DTXSID5021251 TK.Half.Life NA 1.683 hours 1compartment NA NA Rat Human +DTXSID5021251 Css NA 0.08444 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021251 Css NA 0.2351 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021251 Css NA 0.05631 mg/L PBTK NA 50% Rat Human +DTXSID5021251 Css NA 0.1461 mg/L PBTK NA 95% Rat Human +DTXSID5021253 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021253 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021253 Vd NA 0.5825 L/kg 1compartment NA NA Human Human DTXSID5021253 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021253 TK.Half.Life NA 7.421 hours 1compartment NA NA Human Human -DTXSID5021253 Css NA 2.748 mg/L 3compartmentss NA 50% Human Human -DTXSID5021253 Css NA 10.61 mg/L 3compartmentss NA 95% Human Human -DTXSID5021253 Css NA 1.811 mg/L PBTK NA 50% Human Human -DTXSID5021253 Css NA 6.523 mg/L PBTK NA 95% Human Human -DTXSID5021253 Clint NA 0.05249 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021253 Fup NA 0.2638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021253 Vd NA 0.3311 L/kg 1compartment NA NA Rat Human +DTXSID5021253 TK.Half.Life NA 9.42 hours 1compartment NA NA Human Human +DTXSID5021253 Css NA 1.716 mg/L 3compartmentss NA 50% Human Human +DTXSID5021253 Css NA 7.592 mg/L 3compartmentss NA 95% Human Human +DTXSID5021253 Css NA 1.298 mg/L PBTK NA 50% Human Human +DTXSID5021253 Css NA 4.895 mg/L PBTK NA 95% Human Human +DTXSID5021253 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021253 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021253 Vd NA 0.5925 L/kg 1compartment NA NA Rat Human DTXSID5021253 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021253 TK.Half.Life NA 2.656 hours 1compartment NA NA Rat Human -DTXSID5021253 Css NA 0.8053 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021253 Css NA 2.599 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021253 Css NA 0.5017 mg/L PBTK NA 50% Rat Human -DTXSID5021253 Css NA 1.478 mg/L PBTK NA 95% Rat Human +DTXSID5021253 TK.Half.Life NA 3.265 hours 1compartment NA NA Rat Human +DTXSID5021253 Css NA 0.109 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021253 Css NA 0.4258 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021253 Css NA 0.0818 mg/L PBTK NA 50% Rat Human +DTXSID5021253 Css NA 0.2634 mg/L PBTK NA 95% Rat Human DTXSID5021255 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5021255 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5021255 Vd NA 3.67 L/kg 1compartment NA NA Human Human +DTXSID5021255 Vd NA 3.858 L/kg 1compartment NA NA Human Human DTXSID5021255 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5021255 TK.Half.Life NA 25.85 hours 1compartment NA NA Human Human -DTXSID5021255 Css NA 0.5914 mg/L 3compartmentss NA 50% Human Human -DTXSID5021255 Css NA 4.404 mg/L 3compartmentss NA 95% Human Human -DTXSID5021255 Css NA 0.7582 mg/L PBTK NA 50% Human Human -DTXSID5021255 Css NA 3.44 mg/L PBTK NA 95% Human Human +DTXSID5021255 TK.Half.Life NA 27.2 hours 1compartment NA NA Human Human +DTXSID5021255 Css NA 0.5024 mg/L 3compartmentss NA 50% Human Human +DTXSID5021255 Css NA 3.655 mg/L 3compartmentss NA 95% Human Human +DTXSID5021255 Css NA 0.6573 mg/L PBTK NA 50% Human Human +DTXSID5021255 Css NA 2.948 mg/L PBTK NA 95% Human Human DTXSID5021255 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID5021255 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5021255 Vd NA 3.742 L/kg 1compartment NA NA Rat Human +DTXSID5021255 Vd NA 3.938 L/kg 1compartment NA NA Rat Human DTXSID5021255 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021255 TK.Half.Life NA 8.972 hours 1compartment NA NA Rat Human -DTXSID5021255 Css NA 0.147 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021255 Css NA 1.065 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021255 Css NA 0.1888 mg/L PBTK NA 50% Rat Human -DTXSID5021255 Css NA 0.7698 mg/L PBTK NA 95% Rat Human +DTXSID5021255 TK.Half.Life NA 9.445 hours 1compartment NA NA Rat Human +DTXSID5021255 Css NA 0.01276 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021255 Css NA 0.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021255 Css NA 0.01674 mg/L PBTK NA 50% Rat Human +DTXSID5021255 Css NA 0.087 mg/L PBTK NA 95% Rat Human DTXSID5021330 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021330 Fup NA 0.9144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021330 Vd NA 0.7302 L/kg 1compartment NA NA Human Human +DTXSID5021330 Vd NA 1.18 L/kg 1compartment NA NA Human Human DTXSID5021330 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021330 TK.Half.Life NA 5.169 hours 1compartment NA NA Human Human -DTXSID5021330 Css NA 0.887 mg/L 3compartmentss NA 50% Human Human -DTXSID5021330 Css NA 3.217 mg/L 3compartmentss NA 95% Human Human -DTXSID5021330 Css NA 0.734 mg/L PBTK NA 50% Human Human -DTXSID5021330 Css NA 2.244 mg/L PBTK NA 95% Human Human +DTXSID5021330 TK.Half.Life NA 8.7 hours 1compartment NA NA Human Human +DTXSID5021330 Css NA 0.8004 mg/L 3compartmentss NA 50% Human Human +DTXSID5021330 Css NA 3.057 mg/L 3compartmentss NA 95% Human Human +DTXSID5021330 Css NA 0.7274 mg/L PBTK NA 50% Human Human +DTXSID5021330 Css NA 2.222 mg/L PBTK NA 95% Human Human DTXSID5021330 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021330 Fup NA 0.9144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021330 Vd NA 0.7667 L/kg 1compartment NA NA Rat Human +DTXSID5021330 Vd NA 1.13 L/kg 1compartment NA NA Rat Human DTXSID5021330 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021330 TK.Half.Life NA 1.849 hours 1compartment NA NA Rat Human -DTXSID5021330 Css NA 0.2296 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021330 Css NA 0.7961 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021330 Css NA 0.185 mg/L PBTK NA 50% Rat Human -DTXSID5021330 Css NA 0.507 mg/L PBTK NA 95% Rat Human +DTXSID5021330 TK.Half.Life NA 2.752 hours 1compartment NA NA Rat Human +DTXSID5021330 Css NA 0.04725 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021330 Css NA 0.1702 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021330 Css NA 0.04372 mg/L PBTK NA 50% Rat Human +DTXSID5021330 Css NA 0.1183 mg/L PBTK NA 95% Rat Human DTXSID5021332 Clint 816 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021332 Fup 3.86e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021332 Vd NA 0.1606 L/kg 1compartment NA NA Human Human DTXSID5021332 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021332 TK.Half.Life NA 7.516 hours 1compartment NA NA Human Human -DTXSID5021332 Css NA 2.956 mg/L 3compartmentss NA 50% Human Human -DTXSID5021332 Css NA 20.92 mg/L 3compartmentss NA 95% Human Human -DTXSID5021332 Css NA 1.72 mg/L PBTK NA 50% Human Human -DTXSID5021332 Css NA 12.03 mg/L PBTK NA 95% Human Human +DTXSID5021332 Css NA 2.896 mg/L 3compartmentss NA 50% Human Human +DTXSID5021332 Css NA 21.55 mg/L 3compartmentss NA 95% Human Human +DTXSID5021332 Css NA 1.695 mg/L PBTK NA 50% Human Human +DTXSID5021332 Css NA 12.32 mg/L PBTK NA 95% Human Human DTXSID5021332 Clint 816 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5021332 Fup 3.86e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5021332 Vd NA 0.1586 L/kg 1compartment NA NA Rat Human DTXSID5021332 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021332 TK.Half.Life NA 5.165 hours 1compartment NA NA Rat Human -DTXSID5021332 Css NA 2.176 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021332 Css NA 8.115 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021332 Css NA 1.176 mg/L PBTK NA 50% Rat Human -DTXSID5021332 Css NA 4.383 mg/L PBTK NA 95% Rat Human +DTXSID5021332 Css NA 0.488 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021332 Css NA 1.984 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021332 Css NA 0.2727 mg/L PBTK NA 50% Rat Human +DTXSID5021332 Css NA 1.11 mg/L PBTK NA 95% Rat Human DTXSID5021334 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021334 Fup NA 0.6319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021334 Vd NA 0.7365 L/kg 1compartment NA NA Human Human +DTXSID5021334 Vd NA 0.7121 L/kg 1compartment NA NA Human Human DTXSID5021334 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021334 TK.Half.Life NA 7.585 hours 1compartment NA NA Human Human -DTXSID5021334 Css NA 1.166 mg/L 3compartmentss NA 50% Human Human -DTXSID5021334 Css NA 7.29 mg/L 3compartmentss NA 95% Human Human -DTXSID5021334 Css NA 0.9454 mg/L PBTK NA 50% Human Human -DTXSID5021334 Css NA 4.656 mg/L PBTK NA 95% Human Human +DTXSID5021334 TK.Half.Life NA 7.323 hours 1compartment NA NA Human Human +DTXSID5021334 Css NA 0.9849 mg/L 3compartmentss NA 50% Human Human +DTXSID5021334 Css NA 6.532 mg/L 3compartmentss NA 95% Human Human +DTXSID5021334 Css NA 0.7997 mg/L PBTK NA 50% Human Human +DTXSID5021334 Css NA 4.062 mg/L PBTK NA 95% Human Human DTXSID5021334 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021334 Fup NA 0.6319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021334 Vd NA 0.7404 L/kg 1compartment NA NA Rat Human +DTXSID5021334 Vd NA 0.7203 L/kg 1compartment NA NA Rat Human DTXSID5021334 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021334 TK.Half.Life NA 2.586 hours 1compartment NA NA Rat Human -DTXSID5021334 Css NA 0.3123 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021334 Css NA 1.885 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021334 Css NA 0.2425 mg/L PBTK NA 50% Rat Human -DTXSID5021334 Css NA 1.115 mg/L PBTK NA 95% Rat Human +DTXSID5021334 TK.Half.Life NA 2.515 hours 1compartment NA NA Rat Human +DTXSID5021334 Css NA 0.01915 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021334 Css NA 0.1523 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021334 Css NA 0.01488 mg/L PBTK NA 50% Rat Human +DTXSID5021334 Css NA 0.0992 mg/L PBTK NA 95% Rat Human DTXSID5021336 Clint 0.7788 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5021336 Fup 0.61 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5021336 Vd NA 0.6268 L/kg 1compartment NA NA Human Human DTXSID5021336 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021336 TK.Half.Life NA 2.994 hours 1compartment NA NA Human Human -DTXSID5021336 Css NA 0.3339 mg/L 3compartmentss NA 50% Human Human -DTXSID5021336 Css NA 3.212 mg/L 3compartmentss NA 95% Human Human -DTXSID5021336 Css NA 0.4209 mg/L PBTK NA 50% Human Human -DTXSID5021336 Css NA 2.41 mg/L PBTK NA 95% Human Human +DTXSID5021336 Css NA 0.3116 mg/L 3compartmentss NA 50% Human Human +DTXSID5021336 Css NA 1.734 mg/L 3compartmentss NA 95% Human Human +DTXSID5021336 Css NA 0.4132 mg/L PBTK NA 50% Human Human +DTXSID5021336 Css NA 2.306 mg/L PBTK NA 95% Human Human DTXSID5021336 Clint 0.7788 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID5021336 Fup 0.61 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5021336 Vd NA 0.6356 L/kg 1compartment NA NA Rat Human DTXSID5021336 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021336 TK.Half.Life NA 1.431 hours 1compartment NA NA Rat Human -DTXSID5021336 Css NA 0.1226 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021336 Css NA 1.138 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021336 Css NA 0.1543 mg/L PBTK NA 50% Rat Human -DTXSID5021336 Css NA 0.7768 mg/L PBTK NA 95% Rat Human -DTXSID5021338 Clint NA 3.116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021338 Fup NA 0.2851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021338 Vd NA 0.4335 L/kg 1compartment NA NA Human Human +DTXSID5021336 Css NA 0.02598 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021336 Css NA 0.1329 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021336 Css NA 0.03578 mg/L PBTK NA 50% Rat Human +DTXSID5021336 Css NA 0.183 mg/L PBTK NA 95% Rat Human +DTXSID5021338 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021338 Fup 0.336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021338 Vd NA 0.472 L/kg 1compartment NA NA Human Human DTXSID5021338 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021338 TK.Half.Life NA 1.844 hours 1compartment NA NA Human Human -DTXSID5021338 Css NA 0.4607 mg/L 3compartmentss NA 50% Human Human -DTXSID5021338 Css NA 2.407 mg/L 3compartmentss NA 95% Human Human -DTXSID5021338 Css NA 0.3171 mg/L PBTK NA 50% Human Human -DTXSID5021338 Css NA 1.537 mg/L PBTK NA 95% Human Human -DTXSID5021338 Clint NA 3.116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021338 Fup NA 0.2851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021338 Vd NA 0.4406 L/kg 1compartment NA NA Rat Human +DTXSID5021338 TK.Half.Life NA 9.098 hours 1compartment NA NA Human Human +DTXSID5021338 Css NA 1.192 mg/L 3compartmentss NA 50% Human Human +DTXSID5021338 Css NA 5.296 mg/L 3compartmentss NA 95% Human Human +DTXSID5021338 Css NA 0.8448 mg/L PBTK NA 50% Human Human +DTXSID5021338 Css NA 3.334 mg/L PBTK NA 95% Human Human +DTXSID5021338 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021338 Fup 0.336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021338 Vd NA 0.4805 L/kg 1compartment NA NA Rat Human DTXSID5021338 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021338 TK.Half.Life NA 1.052 hours 1compartment NA NA Rat Human -DTXSID5021338 Css NA 0.2226 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021338 Css NA 0.865 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021338 Css NA 0.1451 mg/L PBTK NA 50% Rat Human -DTXSID5021338 Css NA 0.5099 mg/L PBTK NA 95% Rat Human +DTXSID5021338 TK.Half.Life NA 3.154 hours 1compartment NA NA Rat Human +DTXSID5021338 Css NA 0.006494 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021338 Css NA 0.02862 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021338 Css NA 0.004356 mg/L PBTK NA 50% Rat Human +DTXSID5021338 Css NA 0.01716 mg/L PBTK NA 95% Rat Human DTXSID5021386 Clint 18.76 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5021386 Fup 0.01512 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5021386 Vd NA 1.321 L/kg 1compartment NA NA Human Human DTXSID5021386 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID5021386 TK.Half.Life NA 16.33 hours 1compartment NA NA Human Human -DTXSID5021386 Css NA 1.74 mg/L 3compartmentss NA 50% Human Human -DTXSID5021386 Css NA 18.28 mg/L 3compartmentss NA 95% Human Human -DTXSID5021386 Css NA 1.289 mg/L PBTK NA 50% Human Human -DTXSID5021386 Css NA 11.81 mg/L PBTK NA 95% Human Human +DTXSID5021386 Css NA 1.699 mg/L 3compartmentss NA 50% Human Human +DTXSID5021386 Css NA 18.1 mg/L 3compartmentss NA 95% Human Human +DTXSID5021386 Css NA 1.261 mg/L PBTK NA 50% Human Human +DTXSID5021386 Css NA 11.52 mg/L PBTK NA 95% Human Human DTXSID5021386 Clint 18.76 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5021386 Fup 0.01512 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5021386 Vd NA 1.101 L/kg 1compartment NA NA Rat Human DTXSID5021386 Days.Css NA 45 Days PBTK NA NA Rat Human DTXSID5021386 TK.Half.Life NA 167.9 hours 1compartment NA NA Rat Human -DTXSID5021386 Css NA 19.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021386 Css NA 110.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021386 Css NA 13.38 mg/L PBTK NA 50% Rat Human -DTXSID5021386 Css NA 63.29 mg/L PBTK NA 95% Rat Human +DTXSID5021386 Css NA 4.235 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021386 Css NA 24.43 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021386 Css NA 3.083 mg/L PBTK NA 50% Rat Human +DTXSID5021386 Css NA 14.52 mg/L PBTK NA 95% Rat Human DTXSID5021388 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021388 Fup 0.0127 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021388 Vd NA 0.2284 L/kg 1compartment NA NA Human Human DTXSID5021388 Days.Css NA 25 Days PBTK NA NA Human Human DTXSID5021388 TK.Half.Life NA 116.3 hours 1compartment NA NA Human Human -DTXSID5021388 Css NA 55.94 mg/L 3compartmentss NA 50% Human Human -DTXSID5021388 Css NA 194.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5021388 Css NA 33.42 mg/L PBTK NA 50% Human Human -DTXSID5021388 Css NA 113.2 mg/L PBTK NA 95% Human Human +DTXSID5021388 Css NA 53.22 mg/L 3compartmentss NA 50% Human Human +DTXSID5021388 Css NA 183.3 mg/L 3compartmentss NA 95% Human Human +DTXSID5021388 Css NA 31.84 mg/L PBTK NA 50% Human Human +DTXSID5021388 Css NA 108.7 mg/L PBTK NA 95% Human Human DTXSID5021388 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5021388 Fup 0.0137 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5021388 Vd NA 0.2265 L/kg 1compartment NA NA Rat Rat DTXSID5021388 Days.Css NA 6 Days PBTK NA NA Rat Rat DTXSID5021388 TK.Half.Life NA 36.44 hours 1compartment NA NA Rat Rat -DTXSID5021388 Css NA 23.13 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5021388 Css NA 124.8 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5021388 Css NA 12.78 mg/L PBTK NA 50% Rat Rat -DTXSID5021388 Css NA 67.69 mg/L PBTK NA 95% Rat Rat +DTXSID5021388 Css NA 4.628 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5021388 Css NA 25.53 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5021388 Css NA 2.648 mg/L PBTK NA 50% Rat Rat +DTXSID5021388 Css NA 14.34 mg/L PBTK NA 95% Rat Rat DTXSID5021411 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021411 Fup 0.44 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5021411 Vd NA 1.101 L/kg 1compartment NA NA Human Human DTXSID5021411 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID5021411 TK.Half.Life NA 17.62 hours 1compartment NA NA Human Human -DTXSID5021411 Css NA 0.3209 mg/L 3compartmentss NA 50% Human Human -DTXSID5021411 Css NA 1.323 mg/L 3compartmentss NA 95% Human Human -DTXSID5021411 Css NA 0.2593 mg/L PBTK NA 50% Human Human -DTXSID5021411 Css NA 0.9777 mg/L PBTK NA 95% Human Human +DTXSID5021411 Css NA 0.3117 mg/L 3compartmentss NA 50% Human Human +DTXSID5021411 Css NA 1.284 mg/L 3compartmentss NA 95% Human Human +DTXSID5021411 Css NA 0.2508 mg/L PBTK NA 50% Human Human +DTXSID5021411 Css NA 0.9539 mg/L PBTK NA 95% Human Human DTXSID5021411 Clint 6.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5021411 Fup 0.397 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5021411 Vd NA 0.9144 L/kg 1compartment NA NA Rat Rat DTXSID5021411 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID5021411 TK.Half.Life NA 0.9781 hours 1compartment NA NA Rat Rat -DTXSID5021411 Css NA 0.0798 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5021411 Css NA 0.3837 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5021411 Css NA 0.05988 mg/L PBTK NA 50% Rat Rat -DTXSID5021411 Css NA 0.2488 mg/L PBTK NA 95% Rat Rat -DTXSID5021415 Clint NA 2.269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021415 Fup NA 0.7796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021415 Vd NA 2.386 L/kg 1compartment NA NA Human Human -DTXSID5021415 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021415 TK.Half.Life NA 4.834 hours 1compartment NA NA Human Human -DTXSID5021415 Css NA 0.1714 mg/L 3compartmentss NA 50% Human Human -DTXSID5021415 Css NA 1.476 mg/L 3compartmentss NA 95% Human Human -DTXSID5021415 Css NA 0.1817 mg/L PBTK NA 50% Human Human -DTXSID5021415 Css NA 1.088 mg/L PBTK NA 95% Human Human -DTXSID5021415 Clint NA 2.269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021415 Fup NA 0.7796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021415 Vd NA 2.42 L/kg 1compartment NA NA Rat Human +DTXSID5021411 Css NA 0.01782 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5021411 Css NA 0.09236 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5021411 Css NA 0.01391 mg/L PBTK NA 50% Rat Rat +DTXSID5021411 Css NA 0.05998 mg/L PBTK NA 95% Rat Rat +DTXSID5021413 Clint 177 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID5021413 Fup 0.00703 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID5021413 Vd NA 2.011 L/kg 1compartment NA NA Human Human +DTXSID5021413 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5021413 TK.Half.Life NA 6.307 hours 1compartment NA NA Human Human +DTXSID5021413 Css NA 0.2094 mg/L 3compartmentss NA 50% Human Human +DTXSID5021413 Css NA 2.238 mg/L 3compartmentss NA 95% Human Human +DTXSID5021413 Css NA 0.1376 mg/L PBTK NA 50% Human Human +DTXSID5021413 Css NA 1.439 mg/L PBTK NA 95% Human Human +DTXSID5021413 Clint 177 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID5021413 Fup 0.00703 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID5021413 Vd NA 1.488 L/kg 1compartment NA NA Rat Human +DTXSID5021413 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5021413 TK.Half.Life NA 2.03 hours 1compartment NA NA Rat Human +DTXSID5021413 Css NA 0.00789 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021413 Css NA 0.0999 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021413 Css NA 0.004983 mg/L PBTK NA 50% Rat Human +DTXSID5021413 Css NA 0.06263 mg/L PBTK NA 95% Rat Human +DTXSID5021415 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021415 Fup 0.74 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021415 Vd NA 2.169 L/kg 1compartment NA NA Human Human +DTXSID5021415 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5021415 TK.Half.Life NA 18.96 hours 1compartment NA NA Human Human +DTXSID5021415 Css NA 0.7887 mg/L 3compartmentss NA 50% Human Human +DTXSID5021415 Css NA 6.004 mg/L 3compartmentss NA 95% Human Human +DTXSID5021415 Css NA 0.8246 mg/L PBTK NA 50% Human Human +DTXSID5021415 Css NA 4.243 mg/L PBTK NA 95% Human Human +DTXSID5021415 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021415 Fup 0.74 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021415 Vd NA 2.2 L/kg 1compartment NA NA Rat Human DTXSID5021415 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021415 TK.Half.Life NA 2.622 hours 1compartment NA NA Rat Human -DTXSID5021415 Css NA 0.07167 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021415 Css NA 0.5852 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021415 Css NA 0.07634 mg/L PBTK NA 50% Rat Human -DTXSID5021415 Css NA 0.3909 mg/L PBTK NA 95% Rat Human -DTXSID5021419 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021419 Fup NA 0.9876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021419 Vd NA 0.771 L/kg 1compartment NA NA Human Human +DTXSID5021415 TK.Half.Life NA 6.558 hours 1compartment NA NA Rat Human +DTXSID5021415 Css NA 0.04597 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021415 Css NA 0.3562 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021415 Css NA 0.0492 mg/L PBTK NA 50% Rat Human +DTXSID5021415 Css NA 0.237 mg/L PBTK NA 95% Rat Human +DTXSID5021419 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021419 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021419 Vd NA 0.4046 L/kg 1compartment NA NA Human Human DTXSID5021419 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021419 TK.Half.Life NA 5.056 hours 1compartment NA NA Human Human -DTXSID5021419 Css NA 0.8635 mg/L 3compartmentss NA 50% Human Human -DTXSID5021419 Css NA 4.772 mg/L 3compartmentss NA 95% Human Human -DTXSID5021419 Css NA 0.7218 mg/L PBTK NA 50% Human Human -DTXSID5021419 Css NA 3.163 mg/L PBTK NA 95% Human Human -DTXSID5021419 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021419 Fup NA 0.9876 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021419 Vd NA 0.8074 L/kg 1compartment NA NA Rat Human +DTXSID5021419 TK.Half.Life NA 8.029 hours 1compartment NA NA Human Human +DTXSID5021419 Css NA 2.274 mg/L 3compartmentss NA 50% Human Human +DTXSID5021419 Css NA 8.991 mg/L 3compartmentss NA 95% Human Human +DTXSID5021419 Css NA 1.577 mg/L PBTK NA 50% Human Human +DTXSID5021419 Css NA 5.611 mg/L PBTK NA 95% Human Human +DTXSID5021419 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021419 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021419 Vd NA 0.4234 L/kg 1compartment NA NA Rat Human DTXSID5021419 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021419 TK.Half.Life NA 1.803 hours 1compartment NA NA Rat Human -DTXSID5021419 Css NA 0.2221 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021419 Css NA 1.192 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021419 Css NA 0.1805 mg/L PBTK NA 50% Rat Human -DTXSID5021419 Css NA 0.7247 mg/L PBTK NA 95% Rat Human +DTXSID5021419 TK.Half.Life NA 2.863 hours 1compartment NA NA Rat Human +DTXSID5021419 Css NA 0.1479 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021419 Css NA 0.4984 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021419 Css NA 0.1002 mg/L PBTK NA 50% Rat Human +DTXSID5021419 Css NA 0.2987 mg/L PBTK NA 95% Rat Human DTXSID5021461 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021461 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021461 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID5021461 Vd NA 0.33 L/kg 1compartment NA NA Human Human DTXSID5021461 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021461 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID5021461 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID5021461 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID5021461 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID5021461 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID5021461 TK.Half.Life NA 6.608 hours 1compartment NA NA Human Human +DTXSID5021461 Css NA 2.055 mg/L 3compartmentss NA 50% Human Human +DTXSID5021461 Css NA 8.59 mg/L 3compartmentss NA 95% Human Human +DTXSID5021461 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID5021461 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID5021461 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021461 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021461 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID5021461 Vd NA 0.3475 L/kg 1compartment NA NA Rat Human DTXSID5021461 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021461 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID5021461 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021461 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021461 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID5021461 Css NA 1.313 mg/L PBTK NA 95% Rat Human -DTXSID5021463 Clint NA 1.442 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021463 Fup NA 0.6502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021463 Vd NA 0.9587 L/kg 1compartment NA NA Human Human -DTXSID5021463 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021463 TK.Half.Life NA 3.216 hours 1compartment NA NA Human Human -DTXSID5021463 Css NA 0.346 mg/L 3compartmentss NA 50% Human Human -DTXSID5021463 Css NA 2.559 mg/L 3compartmentss NA 95% Human Human -DTXSID5021463 Css NA 0.285 mg/L PBTK NA 50% Human Human -DTXSID5021463 Css NA 1.675 mg/L PBTK NA 95% Human Human -DTXSID5021463 Clint NA 1.442 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021463 Fup NA 0.6502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021463 Vd NA 0.8845 L/kg 1compartment NA NA Rat Human +DTXSID5021461 TK.Half.Life NA 2.371 hours 1compartment NA NA Rat Human +DTXSID5021461 Css NA 0.03852 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021461 Css NA 0.2271 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021461 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID5021461 Css NA 0.1369 mg/L PBTK NA 95% Rat Human +DTXSID5021463 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021463 Fup 0.357 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021463 Vd NA 0.61 L/kg 1compartment NA NA Human Human +DTXSID5021463 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5021463 TK.Half.Life NA 11.06 hours 1compartment NA NA Human Human +DTXSID5021463 Css NA 1.889 mg/L 3compartmentss NA 50% Human Human +DTXSID5021463 Css NA 7.872 mg/L 3compartmentss NA 95% Human Human +DTXSID5021463 Css NA 1.457 mg/L PBTK NA 50% Human Human +DTXSID5021463 Css NA 5.148 mg/L PBTK NA 95% Human Human +DTXSID5021463 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021463 Fup 0.357 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021463 Vd NA 0.6096 L/kg 1compartment NA NA Rat Human DTXSID5021463 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021463 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human -DTXSID5021463 Css NA 0.1394 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021463 Css NA 0.9483 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021463 Css NA 0.1124 mg/L PBTK NA 50% Rat Human -DTXSID5021463 Css NA 0.5655 mg/L PBTK NA 95% Rat Human -DTXSID5021544 Clint NA 12.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021544 Fup NA 0.2449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021544 Vd NA 1.325 L/kg 1compartment NA NA Human Human +DTXSID5021463 TK.Half.Life NA 3.765 hours 1compartment NA NA Rat Human +DTXSID5021463 Css NA 0.119 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021463 Css NA 0.4415 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021463 Css NA 0.09145 mg/L PBTK NA 50% Rat Human +DTXSID5021463 Css NA 0.277 mg/L PBTK NA 95% Rat Human +DTXSID50214655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50214655 Fup 0.0101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50214655 Vd NA 2.821 L/kg 1compartment NA NA Human Human +DTXSID50214655 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID50214655 TK.Half.Life NA 58.49 hours 1compartment NA NA Human Human +DTXSID50214655 Css NA 2.405 mg/L 3compartmentss NA 50% Human Human +DTXSID50214655 Css NA 17.43 mg/L 3compartmentss NA 95% Human Human +DTXSID50214655 Css NA 1.618 mg/L PBTK NA 50% Human Human +DTXSID50214655 Css NA 11.55 mg/L PBTK NA 95% Human Human +DTXSID50214655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50214655 Fup 0.0101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50214655 Vd NA 2.107 L/kg 1compartment NA NA Rat Human +DTXSID50214655 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID50214655 TK.Half.Life NA 11.12 hours 1compartment NA NA Rat Human +DTXSID50214655 Css NA 0.1245 mg/L 3compartmentss NA 50% Rat Human +DTXSID50214655 Css NA 0.9168 mg/L 3compartmentss NA 95% Rat Human +DTXSID50214655 Css NA 0.08166 mg/L PBTK NA 50% Rat Human +DTXSID50214655 Css NA 0.5701 mg/L PBTK NA 95% Rat Human +DTXSID5021544 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021544 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021544 Vd NA 1.266 L/kg 1compartment NA NA Human Human DTXSID5021544 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021544 TK.Half.Life NA 2.801 hours 1compartment NA NA Human Human -DTXSID5021544 Css NA 0.1706 mg/L 3compartmentss NA 50% Human Human -DTXSID5021544 Css NA 1.107 mg/L 3compartmentss NA 95% Human Human -DTXSID5021544 Css NA 0.1242 mg/L PBTK NA 50% Human Human -DTXSID5021544 Css NA 0.7493 mg/L PBTK NA 95% Human Human -DTXSID5021544 Clint NA 12.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021544 Fup NA 0.2449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021544 Vd NA 1.068 L/kg 1compartment NA NA Rat Human +DTXSID5021544 TK.Half.Life NA 2.03 hours 1compartment NA NA Human Human +DTXSID5021544 Css NA 0.1021 mg/L 3compartmentss NA 50% Human Human +DTXSID5021544 Css NA 0.7365 mg/L 3compartmentss NA 95% Human Human +DTXSID5021544 Css NA 0.07293 mg/L PBTK NA 50% Human Human +DTXSID5021544 Css NA 0.4877 mg/L PBTK NA 95% Human Human +DTXSID5021544 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021544 Fup 0.224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021544 Vd NA 1.02 L/kg 1compartment NA NA Rat Human DTXSID5021544 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021544 TK.Half.Life NA 1.169 hours 1compartment NA NA Rat Human -DTXSID5021544 Css NA 0.09162 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021544 Css NA 0.4474 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021544 Css NA 0.064 mg/L PBTK NA 50% Rat Human -DTXSID5021544 Css NA 0.2848 mg/L PBTK NA 95% Rat Human +DTXSID5021544 TK.Half.Life NA 0.8368 hours 1compartment NA NA Rat Human +DTXSID5021544 Css NA 0.0129 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021544 Css NA 0.07093 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021544 Css NA 0.009206 mg/L PBTK NA 50% Rat Human +DTXSID5021544 Css NA 0.04746 mg/L PBTK NA 95% Rat Human DTXSID5021546 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021546 Fup NA 0.4897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021546 Vd NA 0.4436 L/kg 1compartment NA NA Human Human DTXSID5021546 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021546 TK.Half.Life NA 5.859 hours 1compartment NA NA Human Human -DTXSID5021546 Css NA 1.55 mg/L 3compartmentss NA 50% Human Human -DTXSID5021546 Css NA 7.41 mg/L 3compartmentss NA 95% Human Human -DTXSID5021546 Css NA 1.131 mg/L PBTK NA 50% Human Human -DTXSID5021546 Css NA 4.615 mg/L PBTK NA 95% Human Human +DTXSID5021546 Css NA 1.288 mg/L 3compartmentss NA 50% Human Human +DTXSID5021546 Css NA 6.612 mg/L 3compartmentss NA 95% Human Human +DTXSID5021546 Css NA 0.9406 mg/L PBTK NA 50% Human Human +DTXSID5021546 Css NA 4.156 mg/L PBTK NA 95% Human Human DTXSID5021546 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021546 Fup NA 0.4897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021546 Vd NA 0.4535 L/kg 1compartment NA NA Rat Human DTXSID5021546 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021546 TK.Half.Life NA 2.041 hours 1compartment NA NA Rat Human -DTXSID5021546 Css NA 0.4174 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021546 Css NA 1.808 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021546 Css NA 0.2901 mg/L PBTK NA 50% Rat Human -DTXSID5021546 Css NA 1.054 mg/L PBTK NA 95% Rat Human -DTXSID5021590 Clint NA 2.431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021590 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021590 Vd NA 0.6997 L/kg 1compartment NA NA Human Human -DTXSID5021590 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5021590 TK.Half.Life NA 25.98 hours 1compartment NA NA Human Human -DTXSID5021590 Css NA 6.368 mg/L 3compartmentss NA 50% Human Human -DTXSID5021590 Css NA 37.9 mg/L 3compartmentss NA 95% Human Human -DTXSID5021590 Css NA 4.01 mg/L PBTK NA 50% Human Human -DTXSID5021590 Css NA 22.46 mg/L PBTK NA 95% Human Human -DTXSID5021590 Clint NA 2.431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021590 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021590 Vd NA 0.557 L/kg 1compartment NA NA Rat Human -DTXSID5021590 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5021590 TK.Half.Life NA 11.5 hours 1compartment NA NA Rat Human -DTXSID5021590 Css NA 3.158 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021590 Css NA 14.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021590 Css NA 1.854 mg/L PBTK NA 50% Rat Human -DTXSID5021590 Css NA 7.936 mg/L PBTK NA 95% Rat Human +DTXSID5021546 Css NA 0.02425 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021546 Css NA 0.1651 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021546 Css NA 0.01698 mg/L PBTK NA 50% Rat Human +DTXSID5021546 Css NA 0.1033 mg/L PBTK NA 95% Rat Human +DTXSID5021590 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021590 Fup 0.0321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021590 Vd NA 0.6784 L/kg 1compartment NA NA Human Human +DTXSID5021590 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5021590 TK.Half.Life NA 4.077 hours 1compartment NA NA Human Human +DTXSID5021590 Css NA 0.9147 mg/L 3compartmentss NA 50% Human Human +DTXSID5021590 Css NA 9.019 mg/L 3compartmentss NA 95% Human Human +DTXSID5021590 Css NA 0.5728 mg/L PBTK NA 50% Human Human +DTXSID5021590 Css NA 5.363 mg/L PBTK NA 95% Human Human +DTXSID5021590 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021590 Fup 0.0321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021590 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human +DTXSID5021590 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5021590 TK.Half.Life NA 2.01 hours 1compartment NA NA Rat Human +DTXSID5021590 Css NA 0.1204 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021590 Css NA 0.8763 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021590 Css NA 0.07298 mg/L PBTK NA 50% Rat Human +DTXSID5021590 Css NA 0.5062 mg/L PBTK NA 95% Rat Human DTXSID5021598 Clint NA 0.8016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021598 Fup NA 0.5491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021598 Vd NA 0.62 L/kg 1compartment NA NA Human Human DTXSID5021598 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021598 TK.Half.Life NA 3.221 hours 1compartment NA NA Human Human -DTXSID5021598 Css NA 0.5588 mg/L 3compartmentss NA 50% Human Human -DTXSID5021598 Css NA 3.674 mg/L 3compartmentss NA 95% Human Human -DTXSID5021598 Css NA 0.4436 mg/L PBTK NA 50% Human Human -DTXSID5021598 Css NA 2.332 mg/L PBTK NA 95% Human Human +DTXSID5021598 Css NA 0.5382 mg/L 3compartmentss NA 50% Human Human +DTXSID5021598 Css NA 3.677 mg/L 3compartmentss NA 95% Human Human +DTXSID5021598 Css NA 0.4286 mg/L PBTK NA 50% Human Human +DTXSID5021598 Css NA 2.321 mg/L PBTK NA 95% Human Human DTXSID5021598 Clint NA 0.8016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021598 Fup NA 0.5491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021598 Vd NA 0.633 L/kg 1compartment NA NA Rat Human DTXSID5021598 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021598 TK.Half.Life NA 1.556 hours 1compartment NA NA Rat Human -DTXSID5021598 Css NA 0.2107 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021598 Css NA 1.314 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021598 Css NA 0.1612 mg/L PBTK NA 50% Rat Human -DTXSID5021598 Css NA 0.7751 mg/L PBTK NA 95% Rat Human -DTXSID5021621 Clint NA 0.001665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021621 Fup NA 0.4272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021621 Vd NA 0.4467 L/kg 1compartment NA NA Human Human +DTXSID5021598 Css NA 0.04706 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021598 Css NA 0.2916 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021598 Css NA 0.03727 mg/L PBTK NA 50% Rat Human +DTXSID5021598 Css NA 0.1777 mg/L PBTK NA 95% Rat Human +DTXSID5021621 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021621 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021621 Vd NA 0.5822 L/kg 1compartment NA NA Human Human DTXSID5021621 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021621 TK.Half.Life NA 6.749 hours 1compartment NA NA Human Human -DTXSID5021621 Css NA 1.734 mg/L 3compartmentss NA 50% Human Human -DTXSID5021621 Css NA 7.979 mg/L 3compartmentss NA 95% Human Human -DTXSID5021621 Css NA 1.255 mg/L PBTK NA 50% Human Human -DTXSID5021621 Css NA 5.009 mg/L PBTK NA 95% Human Human -DTXSID5021621 Clint NA 0.001665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021621 Fup NA 0.4272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021621 Vd NA 0.4501 L/kg 1compartment NA NA Rat Human +DTXSID5021621 TK.Half.Life NA 5.415 hours 1compartment NA NA Human Human +DTXSID5021621 Css NA 0.9472 mg/L 3compartmentss NA 50% Human Human +DTXSID5021621 Css NA 6.327 mg/L 3compartmentss NA 95% Human Human +DTXSID5021621 Css NA 0.7506 mg/L PBTK NA 50% Human Human +DTXSID5021621 Css NA 3.966 mg/L PBTK NA 95% Human Human +DTXSID5021621 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021621 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021621 Vd NA 0.5886 L/kg 1compartment NA NA Rat Human DTXSID5021621 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021621 TK.Half.Life NA 2.32 hours 1compartment NA NA Rat Human -DTXSID5021621 Css NA 0.4767 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021621 Css NA 1.859 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021621 Css NA 0.3286 mg/L PBTK NA 50% Rat Human -DTXSID5021621 Css NA 1.087 mg/L PBTK NA 95% Rat Human -DTXSID5021627 Clint NA 0.0159 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021627 Fup NA 0.2893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021627 Vd NA 0.5473 L/kg 1compartment NA NA Human Human +DTXSID5021621 TK.Half.Life NA 1.865 hours 1compartment NA NA Rat Human +DTXSID5021621 Css NA 0.0182 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021621 Css NA 0.1502 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021621 Css NA 0.0139 mg/L PBTK NA 50% Rat Human +DTXSID5021621 Css NA 0.09305 mg/L PBTK NA 95% Rat Human +DTXSID5021627 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021627 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021627 Vd NA 0.6927 L/kg 1compartment NA NA Human Human DTXSID5021627 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5021627 TK.Half.Life NA 11.93 hours 1compartment NA NA Human Human -DTXSID5021627 Css NA 2.417 mg/L 3compartmentss NA 50% Human Human -DTXSID5021627 Css NA 9.784 mg/L 3compartmentss NA 95% Human Human -DTXSID5021627 Css NA 1.773 mg/L PBTK NA 50% Human Human -DTXSID5021627 Css NA 6.265 mg/L PBTK NA 95% Human Human -DTXSID5021627 Clint NA 0.0159 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021627 Fup NA 0.2893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021627 Vd NA 0.5482 L/kg 1compartment NA NA Rat Human +DTXSID5021627 TK.Half.Life NA 10.42 hours 1compartment NA NA Human Human +DTXSID5021627 Css NA 1.31 mg/L 3compartmentss NA 50% Human Human +DTXSID5021627 Css NA 6.33 mg/L 3compartmentss NA 95% Human Human +DTXSID5021627 Css NA 1.061 mg/L PBTK NA 50% Human Human +DTXSID5021627 Css NA 4.204 mg/L PBTK NA 95% Human Human +DTXSID5021627 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021627 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021627 Vd NA 0.6956 L/kg 1compartment NA NA Rat Human DTXSID5021627 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021627 TK.Half.Life NA 4.126 hours 1compartment NA NA Rat Human -DTXSID5021627 Css NA 0.6823 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021627 Css NA 2.379 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021627 Css NA 0.4774 mg/L PBTK NA 50% Rat Human -DTXSID5021627 Css NA 1.413 mg/L PBTK NA 95% Rat Human +DTXSID5021627 TK.Half.Life NA 3.566 hours 1compartment NA NA Rat Human +DTXSID5021627 Css NA 0.02424 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021627 Css NA 0.1645 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021627 Css NA 0.01901 mg/L PBTK NA 50% Rat Human +DTXSID5021627 Css NA 0.1099 mg/L PBTK NA 95% Rat Human DTXSID5021671 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021671 Fup NA 0.6309 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021671 Vd NA 0.8705 L/kg 1compartment NA NA Human Human DTXSID5021671 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021671 TK.Half.Life NA 9.197 hours 1compartment NA NA Human Human -DTXSID5021671 Css NA 1.177 mg/L 3compartmentss NA 50% Human Human -DTXSID5021671 Css NA 8.178 mg/L 3compartmentss NA 95% Human Human -DTXSID5021671 Css NA 0.9584 mg/L PBTK NA 50% Human Human -DTXSID5021671 Css NA 5.178 mg/L PBTK NA 95% Human Human +DTXSID5021671 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human +DTXSID5021671 Css NA 7.614 mg/L 3compartmentss NA 95% Human Human +DTXSID5021671 Css NA 0.9318 mg/L PBTK NA 50% Human Human +DTXSID5021671 Css NA 4.881 mg/L PBTK NA 95% Human Human DTXSID5021671 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021671 Fup NA 0.6309 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021671 Vd NA 0.8202 L/kg 1compartment NA NA Rat Human DTXSID5021671 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021671 TK.Half.Life NA 2.887 hours 1compartment NA NA Rat Human -DTXSID5021671 Css NA 0.3114 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021671 Css NA 1.877 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021671 Css NA 0.2442 mg/L PBTK NA 50% Rat Human -DTXSID5021671 Css NA 1.114 mg/L PBTK NA 95% Rat Human +DTXSID5021671 Css NA 0.06999 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021671 Css NA 0.421 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021671 Css NA 0.05681 mg/L PBTK NA 50% Rat Human +DTXSID5021671 Css NA 0.2584 mg/L PBTK NA 95% Rat Human DTXSID5021679 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021679 Fup NA 0.4359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021679 Vd NA 1.419 L/kg 1compartment NA NA Human Human -DTXSID5021679 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5021679 TK.Half.Life NA 25.29 hours 1compartment NA NA Human Human -DTXSID5021679 Css NA 1.81 mg/L 3compartmentss NA 50% Human Human -DTXSID5021679 Css NA 8.196 mg/L 3compartmentss NA 95% Human Human -DTXSID5021679 Css NA 1.476 mg/L PBTK NA 50% Human Human -DTXSID5021679 Css NA 5.444 mg/L PBTK NA 95% Human Human +DTXSID5021679 Vd NA 1.208 L/kg 1compartment NA NA Human Human +DTXSID5021679 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5021679 TK.Half.Life NA 20.09 hours 1compartment NA NA Human Human +DTXSID5021679 Css NA 1.67 mg/L 3compartmentss NA 50% Human Human +DTXSID5021679 Css NA 7.534 mg/L 3compartmentss NA 95% Human Human +DTXSID5021679 Css NA 1.34 mg/L PBTK NA 50% Human Human +DTXSID5021679 Css NA 4.958 mg/L PBTK NA 95% Human Human DTXSID5021679 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021679 Fup NA 0.4359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021679 Vd NA 1.194 L/kg 1compartment NA NA Rat Human +DTXSID5021679 Vd NA 1.045 L/kg 1compartment NA NA Rat Human DTXSID5021679 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021679 TK.Half.Life NA 6.33 hours 1compartment NA NA Rat Human -DTXSID5021679 Css NA 0.4904 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021679 Css NA 1.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021679 Css NA 0.3857 mg/L PBTK NA 50% Rat Human -DTXSID5021679 Css NA 1.163 mg/L PBTK NA 95% Rat Human -DTXSID5021708 Clint NA 0.3335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021708 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021708 Vd NA 0.3994 L/kg 1compartment NA NA Human Human -DTXSID5021708 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5021708 TK.Half.Life NA 13.58 hours 1compartment NA NA Human Human -DTXSID5021708 Css NA 4.849 mg/L 3compartmentss NA 50% Human Human -DTXSID5021708 Css NA 24.16 mg/L 3compartmentss NA 95% Human Human -DTXSID5021708 Css NA 3.151 mg/L PBTK NA 50% Human Human -DTXSID5021708 Css NA 14.45 mg/L PBTK NA 95% Human Human -DTXSID5021708 Clint NA 0.3335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021708 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021708 Vd NA 0.3942 L/kg 1compartment NA NA Rat Human +DTXSID5021679 TK.Half.Life NA 5.436 hours 1compartment NA NA Rat Human +DTXSID5021679 Css NA 0.106 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021679 Css NA 0.4153 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021679 Css NA 0.08512 mg/L PBTK NA 50% Rat Human +DTXSID5021679 Css NA 0.2647 mg/L PBTK NA 95% Rat Human +DTXSID5021708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021708 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021708 Vd NA 0.3355 L/kg 1compartment NA NA Human Human +DTXSID5021708 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5021708 TK.Half.Life NA 0.4138 hours 1compartment NA NA Human Human +DTXSID5021708 Css NA 0.05324 mg/L 3compartmentss NA 50% Human Human +DTXSID5021708 Css NA 0.4011 mg/L 3compartmentss NA 95% Human Human +DTXSID5021708 Css NA 0.03516 mg/L PBTK NA 50% Human Human +DTXSID5021708 Css NA 0.2562 mg/L PBTK NA 95% Human Human +DTXSID5021708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021708 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021708 Vd NA 0.3512 L/kg 1compartment NA NA Rat Human DTXSID5021708 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021708 TK.Half.Life NA 5.581 hours 1compartment NA NA Rat Human -DTXSID5021708 Css NA 1.724 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021708 Css NA 7.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021708 Css NA 1.055 mg/L PBTK NA 50% Rat Human -DTXSID5021708 Css NA 3.957 mg/L PBTK NA 95% Rat Human -DTXSID5021754 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021754 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021754 Vd NA 0.8495 L/kg 1compartment NA NA Human Human +DTXSID5021708 TK.Half.Life NA 0.2223 hours 1compartment NA NA Rat Human +DTXSID5021708 Css NA 0.006892 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021708 Css NA 0.03999 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021708 Css NA 0.004486 mg/L PBTK NA 50% Rat Human +DTXSID5021708 Css NA 0.02465 mg/L PBTK NA 95% Rat Human +DTXSID5021754 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021754 Fup 0.859 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021754 Vd NA 0.7741 L/kg 1compartment NA NA Human Human DTXSID5021754 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021754 TK.Half.Life NA 5.51 hours 1compartment NA NA Human Human -DTXSID5021754 Css NA 0.8104 mg/L 3compartmentss NA 50% Human Human -DTXSID5021754 Css NA 5.687 mg/L 3compartmentss NA 95% Human Human -DTXSID5021754 Css NA 0.697 mg/L PBTK NA 50% Human Human -DTXSID5021754 Css NA 3.686 mg/L PBTK NA 95% Human Human -DTXSID5021754 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021754 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021754 Vd NA 0.8769 L/kg 1compartment NA NA Rat Human +DTXSID5021754 TK.Half.Life NA 5.839 hours 1compartment NA NA Human Human +DTXSID5021754 Css NA 0.8008 mg/L 3compartmentss NA 50% Human Human +DTXSID5021754 Css NA 4.934 mg/L 3compartmentss NA 95% Human Human +DTXSID5021754 Css NA 0.6669 mg/L PBTK NA 50% Human Human +DTXSID5021754 Css NA 3.192 mg/L PBTK NA 95% Human Human +DTXSID5021754 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021754 Fup 0.859 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021754 Vd NA 0.7979 L/kg 1compartment NA NA Rat Human DTXSID5021754 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021754 TK.Half.Life NA 1.935 hours 1compartment NA NA Rat Human -DTXSID5021754 Css NA 0.2038 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021754 Css NA 1.243 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021754 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID5021754 Css NA 0.7573 mg/L PBTK NA 95% Rat Human -DTXSID5021756 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021756 Fup NA 0.8626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021756 Vd NA 1.14 L/kg 1compartment NA NA Human Human +DTXSID5021754 TK.Half.Life NA 2.049 hours 1compartment NA NA Rat Human +DTXSID5021754 Css NA 0.01499 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021754 Css NA 0.1122 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021754 Css NA 0.01202 mg/L PBTK NA 50% Rat Human +DTXSID5021754 Css NA 0.07303 mg/L PBTK NA 95% Rat Human +DTXSID5021756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021756 Fup 0.645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021756 Vd NA 0.9225 L/kg 1compartment NA NA Human Human DTXSID5021756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021756 TK.Half.Life NA 8.891 hours 1compartment NA NA Human Human -DTXSID5021756 Css NA 0.8836 mg/L 3compartmentss NA 50% Human Human -DTXSID5021756 Css NA 5.503 mg/L 3compartmentss NA 95% Human Human -DTXSID5021756 Css NA 0.7935 mg/L PBTK NA 50% Human Human -DTXSID5021756 Css NA 3.628 mg/L PBTK NA 95% Human Human -DTXSID5021756 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021756 Fup NA 0.8626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021756 Vd NA 1.09 L/kg 1compartment NA NA Rat Human +DTXSID5021756 TK.Half.Life NA 0.7908 hours 1compartment NA NA Human Human +DTXSID5021756 Css NA 0.02348 mg/L 3compartmentss NA 50% Human Human +DTXSID5021756 Css NA 0.3212 mg/L 3compartmentss NA 95% Human Human +DTXSID5021756 Css NA 0.01951 mg/L PBTK NA 50% Human Human +DTXSID5021756 Css NA 0.2136 mg/L PBTK NA 95% Human Human +DTXSID5021756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021756 Fup 0.645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021756 Vd NA 0.8872 L/kg 1compartment NA NA Rat Human DTXSID5021756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021756 TK.Half.Life NA 2.813 hours 1compartment NA NA Rat Human -DTXSID5021756 Css NA 0.2252 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021756 Css NA 1.437 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021756 Css NA 0.1972 mg/L PBTK NA 50% Rat Human -DTXSID5021756 Css NA 0.8837 mg/L PBTK NA 95% Rat Human -DTXSID5021758 Clint NA 464.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021758 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021758 Vd NA 2.418 L/kg 1compartment NA NA Human Human -DTXSID5021758 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021758 TK.Half.Life NA 2.74 hours 1compartment NA NA Human Human -DTXSID5021758 Css NA 0.04398 mg/L 3compartmentss NA 50% Human Human -DTXSID5021758 Css NA 0.2979 mg/L 3compartmentss NA 95% Human Human -DTXSID5021758 Css NA 0.02948 mg/L PBTK NA 50% Human Human -DTXSID5021758 Css NA 0.189 mg/L PBTK NA 95% Human Human -DTXSID5021758 Clint NA 464.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021758 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021758 Vd NA 1.812 L/kg 1compartment NA NA Rat Human +DTXSID5021756 TK.Half.Life NA 0.3745 hours 1compartment NA NA Rat Human +DTXSID5021756 Css NA 0.000872 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021756 Css NA 0.01195 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021756 Css NA 0.0007151 mg/L PBTK NA 50% Rat Human +DTXSID5021756 Css NA 0.007972 mg/L PBTK NA 95% Rat Human +DTXSID5021758 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021758 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021758 Vd NA 2.872 L/kg 1compartment NA NA Human Human +DTXSID5021758 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5021758 TK.Half.Life NA 16.04 hours 1compartment NA NA Human Human +DTXSID5021758 Css NA 0.5992 mg/L 3compartmentss NA 50% Human Human +DTXSID5021758 Css NA 3.883 mg/L 3compartmentss NA 95% Human Human +DTXSID5021758 Css NA 0.4198 mg/L PBTK NA 50% Human Human +DTXSID5021758 Css NA 2.642 mg/L PBTK NA 95% Human Human +DTXSID5021758 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021758 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021758 Vd NA 2.163 L/kg 1compartment NA NA Rat Human DTXSID5021758 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021758 TK.Half.Life NA 0.8509 hours 1compartment NA NA Rat Human -DTXSID5021758 Css NA 0.02504 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021758 Css NA 0.144 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021758 Css NA 0.0159 mg/L PBTK NA 50% Rat Human -DTXSID5021758 Css NA 0.08858 mg/L PBTK NA 95% Rat Human +DTXSID5021758 TK.Half.Life NA 3.231 hours 1compartment NA NA Rat Human +DTXSID5021758 Css NA 0.0768 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021758 Css NA 0.3919 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021758 Css NA 0.05347 mg/L PBTK NA 50% Rat Human +DTXSID5021758 Css NA 0.2684 mg/L PBTK NA 95% Rat Human DTXSID5021831 Clint 16.82 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5021831 Fup 0.07728 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5021831 Vd NA 1.025 L/kg 1compartment NA NA Human Human DTXSID5021831 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021831 TK.Half.Life NA 3.901 hours 1compartment NA NA Human Human -DTXSID5021831 Css NA 0.5006 mg/L 3compartmentss NA 50% Human Human -DTXSID5021831 Css NA 3.749 mg/L 3compartmentss NA 95% Human Human -DTXSID5021831 Css NA 0.3198 mg/L PBTK NA 50% Human Human -DTXSID5021831 Css NA 2.294 mg/L PBTK NA 95% Human Human +DTXSID5021831 Css NA 0.4844 mg/L 3compartmentss NA 50% Human Human +DTXSID5021831 Css NA 3.538 mg/L 3compartmentss NA 95% Human Human +DTXSID5021831 Css NA 0.3078 mg/L PBTK NA 50% Human Human +DTXSID5021831 Css NA 2.164 mg/L PBTK NA 95% Human Human DTXSID5021831 Clint 16.82 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5021831 Fup 0.07728 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5021831 Vd NA 0.7946 L/kg 1compartment NA NA Rat Human DTXSID5021831 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021831 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human -DTXSID5021831 Css NA 0.2778 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021831 Css NA 1.612 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021831 Css NA 0.1667 mg/L PBTK NA 50% Rat Human -DTXSID5021831 Css NA 0.9265 mg/L PBTK NA 95% Rat Human -DTXSID5021835 Clint NA 23.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021835 Fup NA 0.4472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021835 Vd NA 1.448 L/kg 1compartment NA NA Human Human +DTXSID5021831 Css NA 0.06237 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021831 Css NA 0.3587 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021831 Css NA 0.03866 mg/L PBTK NA 50% Rat Human +DTXSID5021831 Css NA 0.2127 mg/L PBTK NA 95% Rat Human +DTXSID5021835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021835 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021835 Vd NA 1.33 L/kg 1compartment NA NA Human Human DTXSID5021835 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021835 TK.Half.Life NA 1.515 hours 1compartment NA NA Human Human -DTXSID5021835 Css NA 0.04652 mg/L 3compartmentss NA 50% Human Human -DTXSID5021835 Css NA 0.3667 mg/L 3compartmentss NA 95% Human Human -DTXSID5021835 Css NA 0.03738 mg/L PBTK NA 50% Human Human -DTXSID5021835 Css NA 0.2627 mg/L PBTK NA 95% Human Human -DTXSID5021835 Clint NA 23.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021835 Fup NA 0.4472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021835 Vd NA 1.218 L/kg 1compartment NA NA Rat Human +DTXSID5021835 TK.Half.Life NA 1.554 hours 1compartment NA NA Human Human +DTXSID5021835 Css NA 0.0549 mg/L 3compartmentss NA 50% Human Human +DTXSID5021835 Css NA 0.4289 mg/L 3compartmentss NA 95% Human Human +DTXSID5021835 Css NA 0.04294 mg/L PBTK NA 50% Human Human +DTXSID5021835 Css NA 0.3056 mg/L PBTK NA 95% Human Human +DTXSID5021835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021835 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021835 Vd NA 1.116 L/kg 1compartment NA NA Rat Human DTXSID5021835 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021835 TK.Half.Life NA 0.6167 hours 1compartment NA NA Rat Human -DTXSID5021835 Css NA 0.02464 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021835 Css NA 0.1559 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021835 Css NA 0.01943 mg/L PBTK NA 50% Rat Human -DTXSID5021835 Css NA 0.1071 mg/L PBTK NA 95% Rat Human -DTXSID5021837 Clint NA 0.09794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021837 Fup NA 0.8015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021837 Vd NA 2.248 L/kg 1compartment NA NA Human Human -DTXSID5021837 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5021837 TK.Half.Life NA 15.63 hours 1compartment NA NA Human Human -DTXSID5021837 Css NA 0.6486 mg/L 3compartmentss NA 50% Human Human -DTXSID5021837 Css NA 4.33 mg/L 3compartmentss NA 95% Human Human -DTXSID5021837 Css NA 0.6929 mg/L PBTK NA 50% Human Human -DTXSID5021837 Css NA 3.135 mg/L PBTK NA 95% Human Human -DTXSID5021837 Clint NA 0.09794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021837 Fup NA 0.8015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021837 Vd NA 2.262 L/kg 1compartment NA NA Rat Human +DTXSID5021835 TK.Half.Life NA 0.646 hours 1compartment NA NA Rat Human +DTXSID5021835 Css NA 0.006758 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021835 Css NA 0.04013 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021835 Css NA 0.005363 mg/L PBTK NA 50% Rat Human +DTXSID5021835 Css NA 0.02766 mg/L PBTK NA 95% Rat Human +DTXSID5021837 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021837 Fup 0.498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021837 Vd NA 1.544 L/kg 1compartment NA NA Human Human +DTXSID5021837 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5021837 TK.Half.Life NA 20.06 hours 1compartment NA NA Human Human +DTXSID5021837 Css NA 1.011 mg/L 3compartmentss NA 50% Human Human +DTXSID5021837 Css NA 5.807 mg/L 3compartmentss NA 95% Human Human +DTXSID5021837 Css NA 0.9313 mg/L PBTK NA 50% Human Human +DTXSID5021837 Css NA 4.032 mg/L PBTK NA 95% Human Human +DTXSID5021837 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021837 Fup 0.498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021837 Vd NA 1.545 L/kg 1compartment NA NA Rat Human DTXSID5021837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021837 TK.Half.Life NA 5.767 hours 1compartment NA NA Rat Human -DTXSID5021837 Css NA 0.175 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021837 Css NA 1.306 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021837 Css NA 0.1871 mg/L PBTK NA 50% Rat Human -DTXSID5021837 Css NA 0.8572 mg/L PBTK NA 95% Rat Human -DTXSID5021839 Clint NA 1.319 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021839 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021839 Vd NA 3.793 L/kg 1compartment NA NA Human Human +DTXSID5021837 TK.Half.Life NA 6.836 hours 1compartment NA NA Rat Human +DTXSID5021837 Css NA 0.01868 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021837 Css NA 0.1536 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021837 Css NA 0.01694 mg/L PBTK NA 50% Rat Human +DTXSID5021837 Css NA 0.1079 mg/L PBTK NA 95% Rat Human +DTXSID5021839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021839 Fup 0.528 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021839 Vd NA 2.403 L/kg 1compartment NA NA Human Human DTXSID5021839 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021839 TK.Half.Life NA 8.223 hours 1compartment NA NA Human Human -DTXSID5021839 Css NA 0.1707 mg/L 3compartmentss NA 50% Human Human -DTXSID5021839 Css NA 1.547 mg/L 3compartmentss NA 95% Human Human -DTXSID5021839 Css NA 0.2244 mg/L PBTK NA 50% Human Human -DTXSID5021839 Css NA 1.267 mg/L PBTK NA 95% Human Human -DTXSID5021839 Clint NA 1.319 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021839 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021839 Vd NA 3.853 L/kg 1compartment NA NA Rat Human +DTXSID5021839 TK.Half.Life NA 1.895 hours 1compartment NA NA Human Human +DTXSID5021839 Css NA 0.02694 mg/L 3compartmentss NA 50% Human Human +DTXSID5021839 Css NA 0.295 mg/L 3compartmentss NA 95% Human Human +DTXSID5021839 Css NA 0.0282 mg/L PBTK NA 50% Human Human +DTXSID5021839 Css NA 0.2365 mg/L PBTK NA 95% Human Human +DTXSID5021839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021839 Fup 0.528 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021839 Vd NA 2.419 L/kg 1compartment NA NA Rat Human DTXSID5021839 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021839 TK.Half.Life NA 4.237 hours 1compartment NA NA Rat Human -DTXSID5021839 Css NA 0.06344 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021839 Css NA 0.5643 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021839 Css NA 0.08648 mg/L PBTK NA 50% Rat Human -DTXSID5021839 Css NA 0.4099 mg/L PBTK NA 95% Rat Human +DTXSID5021839 TK.Half.Life NA 0.9981 hours 1compartment NA NA Rat Human +DTXSID5021839 Css NA 0.00325 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021839 Css NA 0.03047 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021839 Css NA 0.003528 mg/L PBTK NA 50% Rat Human +DTXSID5021839 Css NA 0.02381 mg/L PBTK NA 95% Rat Human DTXSID5021881 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021881 Fup NA 0.809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021881 Vd NA 1.22 L/kg 1compartment NA NA Human Human DTXSID5021881 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021881 TK.Half.Life NA 9.756 hours 1compartment NA NA Human Human -DTXSID5021881 Css NA 0.8888 mg/L 3compartmentss NA 50% Human Human -DTXSID5021881 Css NA 5.503 mg/L 3compartmentss NA 95% Human Human -DTXSID5021881 Css NA 0.8137 mg/L PBTK NA 50% Human Human -DTXSID5021881 Css NA 3.685 mg/L PBTK NA 95% Human Human +DTXSID5021881 Css NA 0.7541 mg/L 3compartmentss NA 50% Human Human +DTXSID5021881 Css NA 4.88 mg/L 3compartmentss NA 95% Human Human +DTXSID5021881 Css NA 0.6938 mg/L PBTK NA 50% Human Human +DTXSID5021881 Css NA 3.287 mg/L PBTK NA 95% Human Human DTXSID5021881 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021881 Fup NA 0.809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021881 Vd NA 1.256 L/kg 1compartment NA NA Rat Human DTXSID5021881 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021881 TK.Half.Life NA 3.423 hours 1compartment NA NA Rat Human -DTXSID5021881 Css NA 0.2228 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021881 Css NA 1.454 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021881 Css NA 0.2002 mg/L PBTK NA 50% Rat Human -DTXSID5021881 Css NA 0.901 mg/L PBTK NA 95% Rat Human +DTXSID5021881 Css NA 0.01406 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021881 Css NA 0.1169 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021881 Css NA 0.01257 mg/L PBTK NA 50% Rat Human +DTXSID5021881 Css NA 0.0792 mg/L PBTK NA 95% Rat Human DTXSID5021883 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021883 Fup NA 0.7388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021883 Vd NA 0.753 L/kg 1compartment NA NA Human Human DTXSID5021883 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021883 TK.Half.Life NA 6.608 hours 1compartment NA NA Human Human -DTXSID5021883 Css NA 1.034 mg/L 3compartmentss NA 50% Human Human -DTXSID5021883 Css NA 6.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5021883 Css NA 0.8546 mg/L PBTK NA 50% Human Human -DTXSID5021883 Css NA 4.284 mg/L PBTK NA 95% Human Human +DTXSID5021883 Css NA 0.8833 mg/L 3compartmentss NA 50% Human Human +DTXSID5021883 Css NA 5.798 mg/L 3compartmentss NA 95% Human Human +DTXSID5021883 Css NA 0.7276 mg/L PBTK NA 50% Human Human +DTXSID5021883 Css NA 3.671 mg/L PBTK NA 95% Human Human DTXSID5021883 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021883 Fup NA 0.7388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021883 Vd NA 0.7729 L/kg 1compartment NA NA Rat Human DTXSID5021883 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021883 TK.Half.Life NA 2.308 hours 1compartment NA NA Rat Human -DTXSID5021883 Css NA 0.2723 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021883 Css NA 1.678 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021883 Css NA 0.2155 mg/L PBTK NA 50% Rat Human -DTXSID5021883 Css NA 0.9973 mg/L PBTK NA 95% Rat Human -DTXSID5021885 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021885 Fup NA 0.8791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021885 Vd NA 1.277 L/kg 1compartment NA NA Human Human -DTXSID5021885 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5021885 TK.Half.Life NA 10.02 hours 1compartment NA NA Human Human -DTXSID5021885 Css NA 0.8708 mg/L 3compartmentss NA 50% Human Human -DTXSID5021885 Css NA 5.286 mg/L 3compartmentss NA 95% Human Human -DTXSID5021885 Css NA 0.7892 mg/L PBTK NA 50% Human Human -DTXSID5021885 Css NA 3.575 mg/L PBTK NA 95% Human Human -DTXSID5021885 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021885 Fup NA 0.8791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021885 Vd NA 1.194 L/kg 1compartment NA NA Rat Human +DTXSID5021883 Css NA 0.01661 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021883 Css NA 0.1387 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021883 Css NA 0.01317 mg/L PBTK NA 50% Rat Human +DTXSID5021883 Css NA 0.08969 mg/L PBTK NA 95% Rat Human +DTXSID5021885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021885 Fup 0.714 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021885 Vd NA 0.9253 L/kg 1compartment NA NA Human Human +DTXSID5021885 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5021885 TK.Half.Life NA 0.7519 hours 1compartment NA NA Human Human +DTXSID5021885 Css NA 0.02188 mg/L 3compartmentss NA 50% Human Human +DTXSID5021885 Css NA 0.2544 mg/L 3compartmentss NA 95% Human Human +DTXSID5021885 Css NA 0.01815 mg/L PBTK NA 50% Human Human +DTXSID5021885 Css NA 0.183 mg/L PBTK NA 95% Human Human +DTXSID5021885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021885 Fup 0.714 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021885 Vd NA 0.9016 L/kg 1compartment NA NA Rat Human DTXSID5021885 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021885 TK.Half.Life NA 3.041 hours 1compartment NA NA Rat Human -DTXSID5021885 Css NA 0.223 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021885 Css NA 1.322 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021885 Css NA 0.199 mg/L PBTK NA 50% Rat Human -DTXSID5021885 Css NA 0.8264 mg/L PBTK NA 95% Rat Human +DTXSID5021885 TK.Half.Life NA 0.3582 hours 1compartment NA NA Rat Human +DTXSID5021885 Css NA 0.0007742 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021885 Css NA 0.01084 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021885 Css NA 0.0006412 mg/L PBTK NA 50% Rat Human +DTXSID5021885 Css NA 0.007307 mg/L PBTK NA 95% Rat Human DTXSID5021910 Clint NA 0.5301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021910 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5021910 Vd NA 1.221 L/kg 1compartment NA NA Human Human DTXSID5021910 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5021910 TK.Half.Life NA 4.498 hours 1compartment NA NA Human Human -DTXSID5021910 Css NA 0.3999 mg/L 3compartmentss NA 50% Human Human -DTXSID5021910 Css NA 2.86 mg/L 3compartmentss NA 95% Human Human -DTXSID5021910 Css NA 0.3684 mg/L PBTK NA 50% Human Human -DTXSID5021910 Css NA 1.956 mg/L PBTK NA 95% Human Human +DTXSID5021910 Css NA 0.3374 mg/L 3compartmentss NA 50% Human Human +DTXSID5021910 Css NA 2.271 mg/L 3compartmentss NA 95% Human Human +DTXSID5021910 Css NA 0.3118 mg/L PBTK NA 50% Human Human +DTXSID5021910 Css NA 1.569 mg/L PBTK NA 95% Human Human DTXSID5021910 Clint NA 0.5301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021910 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5021910 Vd NA 1.175 L/kg 1compartment NA NA Rat Human DTXSID5021910 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5021910 TK.Half.Life NA 1.853 hours 1compartment NA NA Rat Human -DTXSID5021910 Css NA 0.1335 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021910 Css NA 0.9188 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021910 Css NA 0.1232 mg/L PBTK NA 50% Rat Human -DTXSID5021910 Css NA 0.5689 mg/L PBTK NA 95% Rat Human -DTXSID5021962 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021962 Fup NA 0.5476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021962 Vd NA 0.954 L/kg 1compartment NA NA Human Human -DTXSID5021962 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021962 TK.Half.Life NA 1.779 hours 1compartment NA NA Human Human -DTXSID5021962 Css NA 0.155 mg/L 3compartmentss NA 50% Human Human -DTXSID5021962 Css NA 1.239 mg/L 3compartmentss NA 95% Human Human -DTXSID5021962 Css NA 0.1259 mg/L PBTK NA 50% Human Human -DTXSID5021962 Css NA 0.8348 mg/L PBTK NA 95% Human Human -DTXSID5021962 Clint NA 4.784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021962 Fup NA 0.5476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021962 Vd NA 0.8909 L/kg 1compartment NA NA Rat Human +DTXSID5021910 Css NA 0.007815 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021910 Css NA 0.0719 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021910 Css NA 0.00709 mg/L PBTK NA 50% Rat Human +DTXSID5021910 Css NA 0.05062 mg/L PBTK NA 95% Rat Human +DTXSID5021962 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021962 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021962 Vd NA 1.046 L/kg 1compartment NA NA Human Human +DTXSID5021962 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5021962 TK.Half.Life NA 10.76 hours 1compartment NA NA Human Human +DTXSID5021962 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human +DTXSID5021962 Css NA 7.391 mg/L 3compartmentss NA 95% Human Human +DTXSID5021962 Css NA 0.9115 mg/L PBTK NA 50% Human Human +DTXSID5021962 Css NA 4.76 mg/L PBTK NA 95% Human Human +DTXSID5021962 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021962 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021962 Vd NA 0.9812 L/kg 1compartment NA NA Rat Human DTXSID5021962 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021962 TK.Half.Life NA 0.8953 hours 1compartment NA NA Rat Human -DTXSID5021962 Css NA 0.0752 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021962 Css NA 0.5051 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021962 Css NA 0.05984 mg/L PBTK NA 50% Rat Human -DTXSID5021962 Css NA 0.31 mg/L PBTK NA 95% Rat Human -DTXSID5021968 Clint NA 12.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021968 Fup NA 0.4136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5021968 Vd NA 1 L/kg 1compartment NA NA Human Human +DTXSID5021962 TK.Half.Life NA 3.332 hours 1compartment NA NA Rat Human +DTXSID5021962 Css NA 0.06451 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021962 Css NA 0.4278 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021962 Css NA 0.05551 mg/L PBTK NA 50% Rat Human +DTXSID5021962 Css NA 0.2663 mg/L PBTK NA 95% Rat Human +DTXSID5021968 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021968 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5021968 Vd NA 0.8433 L/kg 1compartment NA NA Human Human DTXSID5021968 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5021968 TK.Half.Life NA 1.401 hours 1compartment NA NA Human Human -DTXSID5021968 Css NA 0.08818 mg/L 3compartmentss NA 50% Human Human -DTXSID5021968 Css NA 0.6321 mg/L 3compartmentss NA 95% Human Human -DTXSID5021968 Css NA 0.06784 mg/L PBTK NA 50% Human Human -DTXSID5021968 Css NA 0.4345 mg/L PBTK NA 95% Human Human -DTXSID5021968 Clint NA 12.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021968 Fup NA 0.4136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5021968 Vd NA 0.8739 L/kg 1compartment NA NA Rat Human +DTXSID5021968 TK.Half.Life NA 1.1 hours 1compartment NA NA Human Human +DTXSID5021968 Css NA 0.0671 mg/L 3compartmentss NA 50% Human Human +DTXSID5021968 Css NA 0.5168 mg/L 3compartmentss NA 95% Human Human +DTXSID5021968 Css NA 0.04848 mg/L PBTK NA 50% Human Human +DTXSID5021968 Css NA 0.348 mg/L PBTK NA 95% Human Human +DTXSID5021968 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021968 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5021968 Vd NA 0.7349 L/kg 1compartment NA NA Rat Human DTXSID5021968 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5021968 TK.Half.Life NA 0.6424 hours 1compartment NA NA Rat Human -DTXSID5021968 Css NA 0.0461 mg/L 3compartmentss NA 50% Rat Human -DTXSID5021968 Css NA 0.2561 mg/L 3compartmentss NA 95% Rat Human -DTXSID5021968 Css NA 0.03398 mg/L PBTK NA 50% Rat Human -DTXSID5021968 Css NA 0.1623 mg/L PBTK NA 95% Rat Human -DTXSID5022061 Clint NA 1.986 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022061 Fup NA 0.5584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022061 Vd NA 1.061 L/kg 1compartment NA NA Human Human +DTXSID5021968 TK.Half.Life NA 0.4994 hours 1compartment NA NA Rat Human +DTXSID5021968 Css NA 0.008503 mg/L 3compartmentss NA 50% Rat Human +DTXSID5021968 Css NA 0.04823 mg/L 3compartmentss NA 95% Rat Human +DTXSID5021968 Css NA 0.006134 mg/L PBTK NA 50% Rat Human +DTXSID5021968 Css NA 0.03225 mg/L PBTK NA 95% Rat Human +DTXSID5022061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022061 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022061 Vd NA 0.5927 L/kg 1compartment NA NA Human Human DTXSID5022061 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022061 TK.Half.Life NA 3.445 hours 1compartment NA NA Human Human -DTXSID5022061 Css NA 0.318 mg/L 3compartmentss NA 50% Human Human -DTXSID5022061 Css NA 2.446 mg/L 3compartmentss NA 95% Human Human -DTXSID5022061 Css NA 0.2576 mg/L PBTK NA 50% Human Human -DTXSID5022061 Css NA 1.606 mg/L PBTK NA 95% Human Human -DTXSID5022061 Clint NA 1.986 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022061 Fup NA 0.5584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022061 Vd NA 0.9417 L/kg 1compartment NA NA Rat Human +DTXSID5022061 TK.Half.Life NA 1 hours 1compartment NA NA Human Human +DTXSID5022061 Css NA 0.1108 mg/L 3compartmentss NA 50% Human Human +DTXSID5022061 Css NA 0.7878 mg/L 3compartmentss NA 95% Human Human +DTXSID5022061 Css NA 0.07425 mg/L PBTK NA 50% Human Human +DTXSID5022061 Css NA 0.5025 mg/L PBTK NA 95% Human Human +DTXSID5022061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022061 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022061 Vd NA 0.5222 L/kg 1compartment NA NA Rat Human DTXSID5022061 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022061 TK.Half.Life NA 1.539 hours 1compartment NA NA Rat Human -DTXSID5022061 Css NA 0.1402 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022061 Css NA 0.9531 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022061 Css NA 0.1115 mg/L PBTK NA 50% Rat Human -DTXSID5022061 Css NA 0.5664 mg/L PBTK NA 95% Rat Human -DTXSID5022198 Clint NA 2.933 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022198 Fup NA 0.7725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022198 Vd NA 1.008 L/kg 1compartment NA NA Human Human +DTXSID5022061 TK.Half.Life NA 0.484 hours 1compartment NA NA Rat Human +DTXSID5022061 Css NA 0.01421 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022061 Css NA 0.07523 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022061 Css NA 0.009399 mg/L PBTK NA 50% Rat Human +DTXSID5022061 Css NA 0.0474 mg/L PBTK NA 95% Rat Human +DTXSID5022140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022140 Fup 0.0987 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022140 Vd NA 1.33 L/kg 1compartment NA NA Human Human +DTXSID5022140 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5022140 TK.Half.Life NA 3.685 hours 1compartment NA NA Human Human +DTXSID5022140 Css NA 0.301 mg/L 3compartmentss NA 50% Human Human +DTXSID5022140 Css NA 2.374 mg/L 3compartmentss NA 95% Human Human +DTXSID5022140 Css NA 0.1974 mg/L PBTK NA 50% Human Human +DTXSID5022140 Css NA 1.486 mg/L PBTK NA 95% Human Human +DTXSID5022140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022140 Fup 0.0987 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022140 Vd NA 1.028 L/kg 1compartment NA NA Rat Human +DTXSID5022140 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5022140 TK.Half.Life NA 1.499 hours 1compartment NA NA Rat Human +DTXSID5022140 Css NA 0.03859 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022140 Css NA 0.2311 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022140 Css NA 0.02486 mg/L PBTK NA 50% Rat Human +DTXSID5022140 Css NA 0.1407 mg/L PBTK NA 95% Rat Human +DTXSID5022146 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022146 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022146 Vd NA 1.857 L/kg 1compartment NA NA Human Human +DTXSID5022146 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5022146 TK.Half.Life NA 4.335 hours 1compartment NA NA Human Human +DTXSID5022146 Css NA 0.2119 mg/L 3compartmentss NA 50% Human Human +DTXSID5022146 Css NA 1.496 mg/L 3compartmentss NA 95% Human Human +DTXSID5022146 Css NA 0.1475 mg/L PBTK NA 50% Human Human +DTXSID5022146 Css NA 0.9842 mg/L PBTK NA 95% Human Human +DTXSID5022146 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022146 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022146 Vd NA 1.426 L/kg 1compartment NA NA Rat Human +DTXSID5022146 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5022146 TK.Half.Life NA 1.531 hours 1compartment NA NA Rat Human +DTXSID5022146 Css NA 0.02679 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022146 Css NA 0.1523 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022146 Css NA 0.01841 mg/L PBTK NA 50% Rat Human +DTXSID5022146 Css NA 0.09844 mg/L PBTK NA 95% Rat Human +DTXSID5022198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022198 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022198 Vd NA 0.857 L/kg 1compartment NA NA Human Human DTXSID5022198 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022198 TK.Half.Life NA 1.866 hours 1compartment NA NA Human Human -DTXSID5022198 Css NA 0.1763 mg/L 3compartmentss NA 50% Human Human -DTXSID5022198 Css NA 1.334 mg/L 3compartmentss NA 95% Human Human -DTXSID5022198 Css NA 0.1496 mg/L PBTK NA 50% Human Human -DTXSID5022198 Css NA 0.9046 mg/L PBTK NA 95% Human Human -DTXSID5022198 Clint NA 2.933 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022198 Fup NA 0.7725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022198 Vd NA 0.9826 L/kg 1compartment NA NA Rat Human +DTXSID5022198 TK.Half.Life NA 0.7727 hours 1compartment NA NA Human Human +DTXSID5022198 Css NA 0.03324 mg/L 3compartmentss NA 50% Human Human +DTXSID5022198 Css NA 0.3717 mg/L 3compartmentss NA 95% Human Human +DTXSID5022198 Css NA 0.02694 mg/L PBTK NA 50% Human Human +DTXSID5022198 Css NA 0.2528 mg/L PBTK NA 95% Human Human +DTXSID5022198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022198 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022198 Vd NA 0.8338 L/kg 1compartment NA NA Rat Human DTXSID5022198 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022198 TK.Half.Life NA 0.9579 hours 1compartment NA NA Rat Human -DTXSID5022198 Css NA 0.07745 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022198 Css NA 0.5529 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022198 Css NA 0.06524 mg/L PBTK NA 50% Rat Human -DTXSID5022198 Css NA 0.3416 mg/L PBTK NA 95% Rat Human -DTXSID5022227 Clint NA 1.351 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022227 Fup NA 0.6558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022227 Vd NA 3.235 L/kg 1compartment NA NA Human Human -DTXSID5022227 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022227 TK.Half.Life NA 10.4 hours 1compartment NA NA Human Human -DTXSID5022227 Css NA 0.2432 mg/L 3compartmentss NA 50% Human Human -DTXSID5022227 Css NA 2.229 mg/L 3compartmentss NA 95% Human Human -DTXSID5022227 Css NA 0.2891 mg/L PBTK NA 50% Human Human -DTXSID5022227 Css NA 1.678 mg/L PBTK NA 95% Human Human -DTXSID5022227 Clint NA 1.351 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022227 Fup NA 0.6558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022227 Vd NA 3.294 L/kg 1compartment NA NA Rat Human -DTXSID5022227 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022227 TK.Half.Life NA 5.411 hours 1compartment NA NA Rat Human -DTXSID5022227 Css NA 0.09238 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022227 Css NA 0.8766 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022227 Css NA 0.1134 mg/L PBTK NA 50% Rat Human -DTXSID5022227 Css NA 0.6066 mg/L PBTK NA 95% Rat Human -DTXSID5022271 Clint NA 4.759 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022271 Fup NA 0.2456 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022271 Vd NA 1.264 L/kg 1compartment NA NA Human Human +DTXSID5022198 TK.Half.Life NA 0.3733 hours 1compartment NA NA Rat Human +DTXSID5022198 Css NA 0.004006 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022198 Css NA 0.03868 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022198 Css NA 0.003292 mg/L PBTK NA 50% Rat Human +DTXSID5022198 Css NA 0.025 mg/L PBTK NA 95% Rat Human +DTXSID5022271 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022271 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022271 Vd NA 1.492 L/kg 1compartment NA NA Human Human DTXSID5022271 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022271 TK.Half.Life NA 4.951 hours 1compartment NA NA Human Human -DTXSID5022271 Css NA 0.3948 mg/L 3compartmentss NA 50% Human Human -DTXSID5022271 Css NA 2.147 mg/L 3compartmentss NA 95% Human Human -DTXSID5022271 Css NA 0.288 mg/L PBTK NA 50% Human Human -DTXSID5022271 Css NA 1.434 mg/L PBTK NA 95% Human Human -DTXSID5022271 Clint NA 4.759 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022271 Fup NA 0.2456 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022271 Vd NA 1.029 L/kg 1compartment NA NA Rat Human +DTXSID5022271 TK.Half.Life NA 3.497 hours 1compartment NA NA Human Human +DTXSID5022271 Css NA 0.1899 mg/L 3compartmentss NA 50% Human Human +DTXSID5022271 Css NA 1.235 mg/L 3compartmentss NA 95% Human Human +DTXSID5022271 Css NA 0.1498 mg/L PBTK NA 50% Human Human +DTXSID5022271 Css NA 0.8695 mg/L PBTK NA 95% Human Human +DTXSID5022271 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022271 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022271 Vd NA 1.23 L/kg 1compartment NA NA Rat Human DTXSID5022271 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022271 TK.Half.Life NA 2.107 hours 1compartment NA NA Rat Human -DTXSID5022271 Css NA 0.1983 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022271 Css NA 0.8093 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022271 Css NA 0.139 mg/L PBTK NA 50% Rat Human -DTXSID5022271 Css NA 0.5111 mg/L PBTK NA 95% Rat Human -DTXSID5022279 Clint NA 6.853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022279 Fup NA 0.1057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022279 Vd NA 2.188 L/kg 1compartment NA NA Human Human -DTXSID5022279 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5022279 TK.Half.Life NA 19.39 hours 1compartment NA NA Human Human -DTXSID5022279 Css NA 1.179 mg/L 3compartmentss NA 50% Human Human -DTXSID5022279 Css NA 6.97 mg/L 3compartmentss NA 95% Human Human -DTXSID5022279 Css NA 0.8046 mg/L PBTK NA 50% Human Human -DTXSID5022279 Css NA 4.541 mg/L PBTK NA 95% Human Human -DTXSID5022279 Clint NA 6.853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022279 Fup NA 0.1057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022279 Vd NA 1.655 L/kg 1compartment NA NA Rat Human +DTXSID5022271 TK.Half.Life NA 1.447 hours 1compartment NA NA Rat Human +DTXSID5022271 Css NA 0.0221 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022271 Css NA 0.1031 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022271 Css NA 0.0176 mg/L PBTK NA 50% Rat Human +DTXSID5022271 Css NA 0.0698 mg/L PBTK NA 95% Rat Human +DTXSID5022279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022279 Fup 0.0646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022279 Vd NA 1.869 L/kg 1compartment NA NA Human Human +DTXSID5022279 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5022279 TK.Half.Life NA 8.056 hours 1compartment NA NA Human Human +DTXSID5022279 Css NA 0.5197 mg/L 3compartmentss NA 50% Human Human +DTXSID5022279 Css NA 3.62 mg/L 3compartmentss NA 95% Human Human +DTXSID5022279 Css NA 0.3417 mg/L PBTK NA 50% Human Human +DTXSID5022279 Css NA 2.219 mg/L PBTK NA 95% Human Human +DTXSID5022279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022279 Fup 0.0646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022279 Vd NA 1.407 L/kg 1compartment NA NA Rat Human DTXSID5022279 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022279 TK.Half.Life NA 5.7 hours 1compartment NA NA Rat Human -DTXSID5022279 Css NA 0.6216 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022279 Css NA 2.732 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022279 Css NA 0.4031 mg/L PBTK NA 50% Rat Human -DTXSID5022279 Css NA 1.656 mg/L PBTK NA 95% Rat Human -DTXSID5022306 Clint NA 170.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022306 Fup NA 0.1989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022306 Vd NA 1.492 L/kg 1compartment NA NA Human Human -DTXSID5022306 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022306 TK.Half.Life NA 1.353 hours 1compartment NA NA Human Human -DTXSID5022306 Css NA 0.01683 mg/L 3compartmentss NA 50% Human Human -DTXSID5022306 Css NA 0.1246 mg/L 3compartmentss NA 95% Human Human -DTXSID5022306 Css NA 0.01211 mg/L PBTK NA 50% Human Human -DTXSID5022306 Css NA 0.08278 mg/L PBTK NA 95% Human Human -DTXSID5022306 Clint NA 170.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022306 Fup NA 0.1989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022306 Vd NA 1.177 L/kg 1compartment NA NA Rat Human -DTXSID5022306 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022306 TK.Half.Life NA 0.4824 hours 1compartment NA NA Rat Human -DTXSID5022306 Css NA 0.009438 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022306 Css NA 0.05622 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022306 Css NA 0.006463 mg/L PBTK NA 50% Rat Human -DTXSID5022306 Css NA 0.03659 mg/L PBTK NA 95% Rat Human +DTXSID5022279 TK.Half.Life NA 2.775 hours 1compartment NA NA Rat Human +DTXSID5022279 Css NA 0.06828 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022279 Css NA 0.3759 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022279 Css NA 0.04406 mg/L PBTK NA 50% Rat Human +DTXSID5022279 Css NA 0.2331 mg/L PBTK NA 95% Rat Human DTXSID5022308 Clint 18.69 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5022308 Fup 0.02426 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5022308 Vd NA 0.9604 L/kg 1compartment NA NA Human Human DTXSID5022308 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5022308 TK.Half.Life NA 8.204 hours 1compartment NA NA Human Human -DTXSID5022308 Css NA 1.313 mg/L 3compartmentss NA 50% Human Human -DTXSID5022308 Css NA 12.25 mg/L 3compartmentss NA 95% Human Human -DTXSID5022308 Css NA 0.8696 mg/L PBTK NA 50% Human Human -DTXSID5022308 Css NA 7.611 mg/L PBTK NA 95% Human Human +DTXSID5022308 Css NA 1.253 mg/L 3compartmentss NA 50% Human Human +DTXSID5022308 Css NA 11.39 mg/L 3compartmentss NA 95% Human Human +DTXSID5022308 Css NA 0.8419 mg/L PBTK NA 50% Human Human +DTXSID5022308 Css NA 7.651 mg/L PBTK NA 95% Human Human DTXSID5022308 Clint 68 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5022308 Fup 0.0085 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5022308 Vd NA 0.4295 L/kg 1compartment NA NA Rat Rat DTXSID5022308 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID5022308 TK.Half.Life NA 1.773 hours 1compartment NA NA Rat Rat -DTXSID5022308 Css NA 0.5419 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5022308 Css NA 5.291 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5022308 Css NA 0.3401 mg/L PBTK NA 50% Rat Rat -DTXSID5022308 Css NA 3.027 mg/L PBTK NA 95% Rat Rat +DTXSID5022308 Css NA 0.1168 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5022308 Css NA 0.9749 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5022308 Css NA 0.08125 mg/L PBTK NA 50% Rat Rat +DTXSID5022308 Css NA 0.6781 mg/L PBTK NA 95% Rat Rat DTXSID5022437 Clint 270 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5022437 Fup 7.14e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5022437 Vd NA 0.1774 L/kg 1compartment NA NA Human Human -DTXSID5022437 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5022437 TK.Half.Life NA 19.79 hours 1compartment NA NA Human Human -DTXSID5022437 Css NA 0.2149 mg/L 3compartmentss NA 50% Human Human -DTXSID5022437 Css NA 3.01 mg/L 3compartmentss NA 95% Human Human -DTXSID5022437 Css NA 0.1284 mg/L PBTK NA 50% Human Human -DTXSID5022437 Css NA 1.743 mg/L PBTK NA 95% Human Human +DTXSID5022437 Vd NA 1.893 L/kg 1compartment NA NA Human Human +DTXSID5022437 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5022437 TK.Half.Life NA 10.9 hours 1compartment NA NA Human Human +DTXSID5022437 Css NA 0.2832 mg/L 3compartmentss NA 50% Human Human +DTXSID5022437 Css NA 1.775 mg/L 3compartmentss NA 95% Human Human +DTXSID5022437 Css NA 0.1952 mg/L PBTK NA 50% Human Human +DTXSID5022437 Css NA 1.204 mg/L PBTK NA 95% Human Human DTXSID5022437 Clint 93.1 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5022437 Fup 0.1285 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID5022437 Vd NA 1.665 L/kg 1compartment NA NA Rat Rat -DTXSID5022437 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID5022437 TK.Half.Life NA 0.9715 hours 1compartment NA NA Rat Rat -DTXSID5022437 Css NA 0.04246 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5022437 Css NA 0.2512 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5022437 Css NA 0.02799 mg/L PBTK NA 50% Rat Rat -DTXSID5022437 Css NA 0.1596 mg/L PBTK NA 95% Rat Rat +DTXSID5022437 Vd NA 2.35 L/kg 1compartment NA NA Rat Rat +DTXSID5022437 Days.Css NA 1 Days PBTK NA NA Rat Rat +DTXSID5022437 TK.Half.Life NA 3.499 hours 1compartment NA NA Rat Rat +DTXSID5022437 Css NA 0.1006 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5022437 Css NA 0.514 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5022437 Css NA 0.06944 mg/L PBTK NA 50% Rat Rat +DTXSID5022437 Css NA 0.3563 mg/L PBTK NA 95% Rat Rat DTXSID5022439 Clint 1.85 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5022439 Fup 0.00918 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5022439 Vd NA 0.1919 L/kg 1compartment NA NA Human Human DTXSID5022439 Days.Css NA 5 Days PBTK NA NA Human Human DTXSID5022439 TK.Half.Life NA 33.39 hours 1compartment NA NA Human Human -DTXSID5022439 Css NA 22.24 mg/L 3compartmentss NA 50% Human Human -DTXSID5022439 Css NA 86.13 mg/L 3compartmentss NA 95% Human Human -DTXSID5022439 Css NA 13.14 mg/L PBTK NA 50% Human Human -DTXSID5022439 Css NA 49.73 mg/L PBTK NA 95% Human Human +DTXSID5022439 Css NA 13.2 mg/L 3compartmentss NA 50% Human Human +DTXSID5022439 Css NA 54.47 mg/L 3compartmentss NA 95% Human Human +DTXSID5022439 Css NA 7.76 mg/L PBTK NA 50% Human Human +DTXSID5022439 Css NA 31.52 mg/L PBTK NA 95% Human Human DTXSID5022439 Clint 1.85 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5022439 Fup 0.00918 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5022439 Vd NA 0.1881 L/kg 1compartment NA NA Rat Human DTXSID5022439 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID5022439 TK.Half.Life NA 18.2 hours 1compartment NA NA Rat Human -DTXSID5022439 Css NA 10.32 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022439 Css NA 28.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022439 Css NA 5.665 mg/L PBTK NA 50% Rat Human -DTXSID5022439 Css NA 15.27 mg/L PBTK NA 95% Rat Human -DTXSID5022481 Clint NA 142.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022481 Fup NA 0.0056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022481 Vd NA 479 L/kg 1compartment NA NA Human Human -DTXSID5022481 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID5022481 TK.Half.Life NA 85.95 hours 1compartment NA NA Human Human -DTXSID5022481 Css NA 0.00032 mg/L 3compartmentss NA 50% Human Human -DTXSID5022481 Css NA 0.008282 mg/L 3compartmentss NA 95% Human Human -DTXSID5022481 Css NA 0.01897 mg/L PBTK NA 50% Human Human -DTXSID5022481 Css NA 0.1726 mg/L PBTK NA 95% Human Human -DTXSID5022481 Clint NA 142.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022481 Fup NA 0.0056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022481 Vd NA 432.8 L/kg 1compartment NA NA Rat Human -DTXSID5022481 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID5022481 TK.Half.Life NA 38.98 hours 1compartment NA NA Rat Human -DTXSID5022481 Css NA 0.0001636 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022481 Css NA 0.003546 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022481 Css NA 0.0101 mg/L PBTK NA 50% Rat Human -DTXSID5022481 Css NA 0.07692 mg/L PBTK NA 95% Rat Human -DTXSID5022485 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022485 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022485 Vd NA 2.548 L/kg 1compartment NA NA Human Human -DTXSID5022485 Days.Css NA 709 Days PBTK NA NA Human Human -DTXSID5022485 TK.Half.Life NA 2667 hours 1compartment NA NA Human Human -DTXSID5022485 Css NA 142 mg/L 3compartmentss NA 50% Human Human -DTXSID5022485 Css NA 510.3 mg/L 3compartmentss NA 95% Human Human -DTXSID5022485 Css NA 94.44 mg/L PBTK NA 50% Human Human -DTXSID5022485 Css NA 312.2 mg/L PBTK NA 95% Human Human -DTXSID5022485 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022485 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022485 Vd NA 1.901 L/kg 1compartment NA NA Rat Human -DTXSID5022485 Days.Css NA 178 Days PBTK NA NA Rat Human -DTXSID5022485 TK.Half.Life NA 305.5 hours 1compartment NA NA Rat Human -DTXSID5022485 Css NA 38.89 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022485 Css NA 115.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022485 Css NA 24.52 mg/L PBTK NA 50% Rat Human -DTXSID5022485 Css NA 66.23 mg/L PBTK NA 95% Rat Human -DTXSID5022489 Clint NA 0.901 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5022439 Css NA 0.128 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022439 Css NA 0.5075 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022439 Css NA 0.0705 mg/L PBTK NA 50% Rat Human +DTXSID5022439 Css NA 0.2777 mg/L PBTK NA 95% Rat Human +DTXSID5022481 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022481 Fup 0.0345 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022481 Vd NA 49.52 L/kg 1compartment NA NA Human Human +DTXSID5022481 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5022481 TK.Half.Life NA 30.89 hours 1compartment NA NA Human Human +DTXSID5022481 Css NA 0.004169 mg/L 3compartmentss NA 50% Human Human +DTXSID5022481 Css NA 0.05008 mg/L 3compartmentss NA 95% Human Human +DTXSID5022481 Css NA 0.0217 mg/L PBTK NA 50% Human Human +DTXSID5022481 Css NA 0.1836 mg/L PBTK NA 95% Human Human +DTXSID5022481 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022481 Fup 0.0345 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022481 Vd NA 42.01 L/kg 1compartment NA NA Rat Human +DTXSID5022481 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5022481 TK.Half.Life NA 8.028 hours 1compartment NA NA Rat Human +DTXSID5022481 Css NA 3.601e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022481 Css NA 0.0004457 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022481 Css NA 0.0001962 mg/L PBTK NA 50% Rat Human +DTXSID5022481 Css NA 0.001807 mg/L PBTK NA 95% Rat Human +DTXSID5022485 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022485 Fup 0.00754 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022485 Vd NA 1.44 L/kg 1compartment NA NA Human Human +DTXSID5022485 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5022485 TK.Half.Life NA 26.04 hours 1compartment NA NA Human Human +DTXSID5022485 Css NA 2.974 mg/L 3compartmentss NA 50% Human Human +DTXSID5022485 Css NA 27.41 mg/L 3compartmentss NA 95% Human Human +DTXSID5022485 Css NA 1.838 mg/L PBTK NA 50% Human Human +DTXSID5022485 Css NA 16.55 mg/L PBTK NA 95% Human Human +DTXSID5022485 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022485 Fup 0.00754 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022485 Vd NA 1.059 L/kg 1compartment NA NA Rat Human +DTXSID5022485 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5022485 TK.Half.Life NA 10.19 hours 1compartment NA NA Rat Human +DTXSID5022485 Css NA 0.391 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022485 Css NA 2.875 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022485 Css NA 0.2342 mg/L PBTK NA 50% Rat Human +DTXSID5022485 Css NA 1.662 mg/L PBTK NA 95% Rat Human +DTXSID5022489 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5022489 Fup 0.0499 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5022489 Vd NA 0.2499 L/kg 1compartment NA NA Human Human -DTXSID5022489 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5022489 TK.Half.Life NA 13.08 hours 1compartment NA NA Human Human -DTXSID5022489 Css NA 6.694 mg/L 3compartmentss NA 50% Human Human -DTXSID5022489 Css NA 31.77 mg/L 3compartmentss NA 95% Human Human -DTXSID5022489 Css NA 4.1 mg/L PBTK NA 50% Human Human -DTXSID5022489 Css NA 18.78 mg/L PBTK NA 95% Human Human -DTXSID5022489 Clint NA 0.901 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5022489 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5022489 TK.Half.Life NA 1.1 hours 1compartment NA NA Human Human +DTXSID5022489 Css NA 0.4717 mg/L 3compartmentss NA 50% Human Human +DTXSID5022489 Css NA 3.663 mg/L 3compartmentss NA 95% Human Human +DTXSID5022489 Css NA 0.2883 mg/L PBTK NA 50% Human Human +DTXSID5022489 Css NA 2.171 mg/L PBTK NA 95% Human Human +DTXSID5022489 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5022489 Fup 0.0499 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5022489 Vd NA 0.2456 L/kg 1compartment NA NA Rat Human DTXSID5022489 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022489 TK.Half.Life NA 6.313 hours 1compartment NA NA Rat Human -DTXSID5022489 Css NA 2.757 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022489 Css NA 10.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022489 Css NA 1.576 mg/L PBTK NA 50% Rat Human -DTXSID5022489 Css NA 5.807 mg/L PBTK NA 95% Rat Human -DTXSID5022510 Clint NA 6.567 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022510 Fup NA 0.2009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022510 Vd NA 2.077 L/kg 1compartment NA NA Human Human +DTXSID5022489 TK.Half.Life NA 0.6789 hours 1compartment NA NA Rat Human +DTXSID5022489 Css NA 0.06179 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022489 Css NA 0.3626 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022489 Css NA 0.03666 mg/L PBTK NA 50% Rat Human +DTXSID5022489 Css NA 0.208 mg/L PBTK NA 95% Rat Human +DTXSID5022510 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022510 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022510 Vd NA 1.621 L/kg 1compartment NA NA Human Human DTXSID5022510 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022510 TK.Half.Life NA 10.3 hours 1compartment NA NA Human Human -DTXSID5022510 Css NA 0.5201 mg/L 3compartmentss NA 50% Human Human -DTXSID5022510 Css NA 2.717 mg/L 3compartmentss NA 95% Human Human -DTXSID5022510 Css NA 0.3776 mg/L PBTK NA 50% Human Human -DTXSID5022510 Css NA 1.88 mg/L PBTK NA 95% Human Human -DTXSID5022510 Clint NA 6.567 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022510 Fup NA 0.2009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022510 Vd NA 1.599 L/kg 1compartment NA NA Rat Human +DTXSID5022510 TK.Half.Life NA 4.557 hours 1compartment NA NA Human Human +DTXSID5022510 Css NA 0.3008 mg/L 3compartmentss NA 50% Human Human +DTXSID5022510 Css NA 2.21 mg/L 3compartmentss NA 95% Human Human +DTXSID5022510 Css NA 0.2005 mg/L PBTK NA 50% Human Human +DTXSID5022510 Css NA 1.393 mg/L PBTK NA 95% Human Human +DTXSID5022510 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022510 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022510 Vd NA 1.238 L/kg 1compartment NA NA Rat Human DTXSID5022510 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022510 TK.Half.Life NA 3.287 hours 1compartment NA NA Rat Human -DTXSID5022510 Css NA 0.2695 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022510 Css NA 1.042 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022510 Css NA 0.188 mg/L PBTK NA 50% Rat Human -DTXSID5022510 Css NA 0.6874 mg/L PBTK NA 95% Rat Human +DTXSID5022510 TK.Half.Life NA 1.709 hours 1compartment NA NA Rat Human +DTXSID5022510 Css NA 0.03819 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022510 Css NA 0.2292 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022510 Css NA 0.02503 mg/L PBTK NA 50% Rat Human +DTXSID5022510 Css NA 0.1426 mg/L PBTK NA 95% Rat Human DTXSID5022514 Clint 6.83e-05 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human -DTXSID5022514 Fup 0 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human +DTXSID5022514 Fup 0.0034 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022514 Vd NA 8.177 L/kg 1compartment NA NA Human Human +DTXSID5022514 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID5022514 TK.Half.Life NA 399700 hours 1compartment NA NA Human Human +DTXSID5022514 Css NA 3574 mg/L 3compartmentss NA 50% Human Human +DTXSID5022514 Css NA 8179 mg/L 3compartmentss NA 95% Human Human +DTXSID5022514 Css NA 3702 mg/L PBTK NA 50% Human Human +DTXSID5022514 Css NA 7901 mg/L PBTK NA 95% Human Human DTXSID5022514 Clint 6.83e-05 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human -DTXSID5022514 Fup 0 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human -DTXSID5022560 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022560 Fup NA 0.4472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022560 Vd NA 0.3132 L/kg 1compartment NA NA Human Human +DTXSID5022514 Fup 0.0034 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022514 Vd NA 6.38 L/kg 1compartment NA NA Rat Human +DTXSID5022514 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID5022514 TK.Half.Life NA 28550 hours 1compartment NA NA Rat Human +DTXSID5022514 Css NA 225.8 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022514 Css NA 324.4 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022514 Css NA 241.4 mg/L PBTK NA 50% Rat Human +DTXSID5022514 Css NA 310.9 mg/L PBTK NA 95% Rat Human +DTXSID5022560 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022560 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022560 Vd NA 0.5588 L/kg 1compartment NA NA Human Human DTXSID5022560 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022560 TK.Half.Life NA 4.53 hours 1compartment NA NA Human Human -DTXSID5022560 Css NA 1.765 mg/L 3compartmentss NA 50% Human Human -DTXSID5022560 Css NA 7.758 mg/L 3compartmentss NA 95% Human Human -DTXSID5022560 Css NA 1.2 mg/L PBTK NA 50% Human Human -DTXSID5022560 Css NA 4.768 mg/L PBTK NA 95% Human Human -DTXSID5022560 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022560 Fup NA 0.4472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022560 Vd NA 0.3294 L/kg 1compartment NA NA Rat Human +DTXSID5022560 TK.Half.Life NA 5.776 hours 1compartment NA NA Human Human +DTXSID5022560 Css NA 1.068 mg/L 3compartmentss NA 50% Human Human +DTXSID5022560 Css NA 6.941 mg/L 3compartmentss NA 95% Human Human +DTXSID5022560 Css NA 0.8236 mg/L PBTK NA 50% Human Human +DTXSID5022560 Css NA 4.334 mg/L PBTK NA 95% Human Human +DTXSID5022560 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022560 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022560 Vd NA 0.5915 L/kg 1compartment NA NA Rat Human DTXSID5022560 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022560 TK.Half.Life NA 1.624 hours 1compartment NA NA Rat Human -DTXSID5022560 Css NA 0.4863 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022560 Css NA 1.822 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022560 Css NA 0.3141 mg/L PBTK NA 50% Rat Human -DTXSID5022560 Css NA 1.042 mg/L PBTK NA 95% Rat Human -DTXSID5022562 Clint NA 18.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022562 Fup NA 0.1142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022562 Vd NA 1.513 L/kg 1compartment NA NA Human Human +DTXSID5022560 TK.Half.Life NA 2.083 hours 1compartment NA NA Rat Human +DTXSID5022560 Css NA 0.02794 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022560 Css NA 0.2222 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022560 Css NA 0.0208 mg/L PBTK NA 50% Rat Human +DTXSID5022560 Css NA 0.1369 mg/L PBTK NA 95% Rat Human +DTXSID5022562 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022562 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022562 Vd NA 1.572 L/kg 1compartment NA NA Human Human DTXSID5022562 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022562 TK.Half.Life NA 4.415 hours 1compartment NA NA Human Human -DTXSID5022562 Css NA 0.3303 mg/L 3compartmentss NA 50% Human Human -DTXSID5022562 Css NA 2.395 mg/L 3compartmentss NA 95% Human Human -DTXSID5022562 Css NA 0.2212 mg/L PBTK NA 50% Human Human -DTXSID5022562 Css NA 1.517 mg/L PBTK NA 95% Human Human -DTXSID5022562 Clint NA 18.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022562 Fup NA 0.1142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022562 Vd NA 1.164 L/kg 1compartment NA NA Rat Human +DTXSID5022562 TK.Half.Life NA 7.706 hours 1compartment NA NA Human Human +DTXSID5022562 Css NA 0.5107 mg/L 3compartmentss NA 50% Human Human +DTXSID5022562 Css NA 2.931 mg/L 3compartmentss NA 95% Human Human +DTXSID5022562 Css NA 0.3598 mg/L PBTK NA 50% Human Human +DTXSID5022562 Css NA 1.961 mg/L PBTK NA 95% Human Human +DTXSID5022562 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022562 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022562 Vd NA 1.224 L/kg 1compartment NA NA Rat Human DTXSID5022562 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022562 TK.Half.Life NA 1.716 hours 1compartment NA NA Rat Human -DTXSID5022562 Css NA 0.1794 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022562 Css NA 0.9947 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022562 Css NA 0.1139 mg/L PBTK NA 50% Rat Human -DTXSID5022562 Css NA 0.5917 mg/L PBTK NA 95% Rat Human -DTXSID5022641 Clint NA 1.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5022562 TK.Half.Life NA 2.943 hours 1compartment NA NA Rat Human +DTXSID5022562 Css NA 0.06142 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022562 Css NA 0.2506 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022562 Css NA 0.04296 mg/L PBTK NA 50% Rat Human +DTXSID5022562 Css NA 0.1621 mg/L PBTK NA 95% Rat Human +DTXSID5022641 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5022641 Fup 0.69 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5022641 Vd NA 0.6359 L/kg 1compartment NA NA Human Human +DTXSID5022641 Vd NA 0.489 L/kg 1compartment NA NA Human Human DTXSID5022641 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022641 TK.Half.Life NA 2.322 hours 1compartment NA NA Human Human -DTXSID5022641 Css NA 0.4169 mg/L 3compartmentss NA 50% Human Human -DTXSID5022641 Css NA 2.728 mg/L 3compartmentss NA 95% Human Human -DTXSID5022641 Css NA 0.33 mg/L PBTK NA 50% Human Human -DTXSID5022641 Css NA 1.767 mg/L PBTK NA 95% Human Human -DTXSID5022641 Clint NA 1.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5022641 TK.Half.Life NA 0.6205 hours 1compartment NA NA Human Human +DTXSID5022641 Css NA 0.09008 mg/L 3compartmentss NA 50% Human Human +DTXSID5022641 Css NA 0.7568 mg/L 3compartmentss NA 95% Human Human +DTXSID5022641 Css NA 0.06712 mg/L PBTK NA 50% Human Human +DTXSID5022641 Css NA 0.4999 mg/L PBTK NA 95% Human Human +DTXSID5022641 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5022641 Fup 0.69 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5022641 Vd NA 0.6633 L/kg 1compartment NA NA Rat Human +DTXSID5022641 Vd NA 0.5135 L/kg 1compartment NA NA Rat Human DTXSID5022641 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022641 TK.Half.Life NA 1.18 hours 1compartment NA NA Rat Human -DTXSID5022641 Css NA 0.1575 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022641 Css NA 1.067 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022641 Css NA 0.1217 mg/L PBTK NA 50% Rat Human -DTXSID5022641 Css NA 0.6253 mg/L PBTK NA 95% Rat Human -DTXSID5022643 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022643 Fup NA 0.7147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022643 Vd NA 0.6964 L/kg 1compartment NA NA Human Human +DTXSID5022641 TK.Half.Life NA 0.3413 hours 1compartment NA NA Rat Human +DTXSID5022641 Css NA 0.01009 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022641 Css NA 0.07757 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022641 Css NA 0.007582 mg/L PBTK NA 50% Rat Human +DTXSID5022641 Css NA 0.0476 mg/L PBTK NA 95% Rat Human +DTXSID5022643 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022643 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022643 Vd NA 0.7263 L/kg 1compartment NA NA Human Human DTXSID5022643 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022643 TK.Half.Life NA 6.436 hours 1compartment NA NA Human Human -DTXSID5022643 Css NA 1.145 mg/L 3compartmentss NA 50% Human Human -DTXSID5022643 Css NA 7.039 mg/L 3compartmentss NA 95% Human Human -DTXSID5022643 Css NA 0.8825 mg/L PBTK NA 50% Human Human -DTXSID5022643 Css NA 4.403 mg/L PBTK NA 95% Human Human -DTXSID5022643 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022643 Fup NA 0.7147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5022643 TK.Half.Life NA 6.25 hours 1compartment NA NA Human Human +DTXSID5022643 Css NA 1.05 mg/L 3compartmentss NA 50% Human Human +DTXSID5022643 Css NA 6.238 mg/L 3compartmentss NA 95% Human Human +DTXSID5022643 Css NA 0.822 mg/L PBTK NA 50% Human Human +DTXSID5022643 Css NA 3.956 mg/L PBTK NA 95% Human Human +DTXSID5022643 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022643 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5022643 Vd NA 0.7735 L/kg 1compartment NA NA Rat Human DTXSID5022643 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5022643 TK.Half.Life NA 1.845 hours 1compartment NA NA Rat Human -DTXSID5022643 Css NA 0.2356 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022643 Css NA 0.8009 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022643 Css NA 0.1838 mg/L PBTK NA 50% Rat Human -DTXSID5022643 Css NA 0.5028 mg/L PBTK NA 95% Rat Human -DTXSID5022647 Clint NA 100.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022647 Fup NA 0.044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022647 Vd NA 0.2502 L/kg 1compartment NA NA Human Human +DTXSID5022643 Css NA 0.05316 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022643 Css NA 0.1732 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022643 Css NA 0.04295 mg/L PBTK NA 50% Rat Human +DTXSID5022643 Css NA 0.1132 mg/L PBTK NA 95% Rat Human +DTXSID5022647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022647 Fup 0.0619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022647 Vd NA 0.2793 L/kg 1compartment NA NA Human Human DTXSID5022647 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022647 TK.Half.Life NA 0.4536 hours 1compartment NA NA Human Human -DTXSID5022647 Css NA 0.1622 mg/L 3compartmentss NA 50% Human Human -DTXSID5022647 Css NA 1.548 mg/L 3compartmentss NA 95% Human Human -DTXSID5022647 Css NA 0.09686 mg/L PBTK NA 50% Human Human -DTXSID5022647 Css NA 0.8958 mg/L PBTK NA 95% Human Human -DTXSID5022647 Clint NA 100.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022647 Fup NA 0.044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022647 Vd NA 0.2325 L/kg 1compartment NA NA Rat Human +DTXSID5022647 TK.Half.Life NA 1.031 hours 1compartment NA NA Human Human +DTXSID5022647 Css NA 0.4522 mg/L 3compartmentss NA 50% Human Human +DTXSID5022647 Css NA 3.636 mg/L 3compartmentss NA 95% Human Human +DTXSID5022647 Css NA 0.273 mg/L PBTK NA 50% Human Human +DTXSID5022647 Css NA 2.158 mg/L PBTK NA 95% Human Human +DTXSID5022647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022647 Fup 0.0619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022647 Vd NA 0.2581 L/kg 1compartment NA NA Rat Human DTXSID5022647 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022647 TK.Half.Life NA 0.2356 hours 1compartment NA NA Rat Human -DTXSID5022647 Css NA 0.09327 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022647 Css NA 0.7063 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022647 Css NA 0.05191 mg/L PBTK NA 50% Rat Human -DTXSID5022647 Css NA 0.3866 mg/L PBTK NA 95% Rat Human -DTXSID5022649 Clint NA 29.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022649 Fup NA 0.0618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022649 Vd NA 0.6827 L/kg 1compartment NA NA Human Human +DTXSID5022647 TK.Half.Life NA 0.5874 hours 1compartment NA NA Rat Human +DTXSID5022647 Css NA 0.02212 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022647 Css NA 0.1915 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022647 Css NA 0.01264 mg/L PBTK NA 50% Rat Human +DTXSID5022647 Css NA 0.1071 mg/L PBTK NA 95% Rat Human +DTXSID5022649 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022649 Fup 0.0666 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022649 Vd NA 0.7096 L/kg 1compartment NA NA Human Human DTXSID5022649 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022649 TK.Half.Life NA 2.021 hours 1compartment NA NA Human Human -DTXSID5022649 Css NA 0.383 mg/L 3compartmentss NA 50% Human Human -DTXSID5022649 Css NA 3.029 mg/L 3compartmentss NA 95% Human Human -DTXSID5022649 Css NA 0.2362 mg/L PBTK NA 50% Human Human -DTXSID5022649 Css NA 1.834 mg/L PBTK NA 95% Human Human -DTXSID5022649 Clint NA 29.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022649 Fup NA 0.0618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022649 Vd NA 0.5445 L/kg 1compartment NA NA Rat Human +DTXSID5022649 TK.Half.Life NA 6.539 hours 1compartment NA NA Human Human +DTXSID5022649 Css NA 1.392 mg/L 3compartmentss NA 50% Human Human +DTXSID5022649 Css NA 8.299 mg/L 3compartmentss NA 95% Human Human +DTXSID5022649 Css NA 0.8692 mg/L PBTK NA 50% Human Human +DTXSID5022649 Css NA 5.027 mg/L PBTK NA 95% Human Human +DTXSID5022649 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022649 Fup 0.0666 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022649 Vd NA 0.5657 L/kg 1compartment NA NA Rat Human DTXSID5022649 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022649 TK.Half.Life NA 0.9464 hours 1compartment NA NA Rat Human -DTXSID5022649 Css NA 0.2178 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022649 Css NA 1.398 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022649 Css NA 0.1257 mg/L PBTK NA 50% Rat Human -DTXSID5022649 Css NA 0.779 mg/L PBTK NA 95% Rat Human -DTXSID5022699 Clint NA 37.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5022649 TK.Half.Life NA 3.1 hours 1compartment NA NA Rat Human +DTXSID5022649 Css NA 0.1698 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022649 Css NA 0.8027 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022649 Css NA 0.1029 mg/L PBTK NA 50% Rat Human +DTXSID5022649 Css NA 0.4673 mg/L PBTK NA 95% Rat Human +DTXSID5022697 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022697 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5022697 Vd NA 4.493 L/kg 1compartment NA NA Human Human +DTXSID5022697 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5022697 TK.Half.Life NA 7.189 hours 1compartment NA NA Human Human +DTXSID5022697 Css NA 0.07912 mg/L 3compartmentss NA 50% Human Human +DTXSID5022697 Css NA 0.6785 mg/L 3compartmentss NA 95% Human Human +DTXSID5022697 Css NA 0.1095 mg/L PBTK NA 50% Human Human +DTXSID5022697 Css NA 0.6853 mg/L PBTK NA 95% Human Human +DTXSID5022697 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022697 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5022697 Vd NA 4.569 L/kg 1compartment NA NA Rat Human +DTXSID5022697 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5022697 TK.Half.Life NA 4.178 hours 1compartment NA NA Rat Human +DTXSID5022697 Css NA 0.008902 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022697 Css NA 0.06008 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022697 Css NA 0.01294 mg/L PBTK NA 50% Rat Human +DTXSID5022697 Css NA 0.05754 mg/L PBTK NA 95% Rat Human +DTXSID5022699 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5022699 Fup 0.031 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5022699 Vd NA 0.3998 L/kg 1compartment NA NA Human Human +DTXSID5022699 Vd NA 0.3387 L/kg 1compartment NA NA Human Human DTXSID5022699 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022699 TK.Half.Life NA 1.616 hours 1compartment NA NA Human Human -DTXSID5022699 Css NA 0.5901 mg/L 3compartmentss NA 50% Human Human -DTXSID5022699 Css NA 5.711 mg/L 3compartmentss NA 95% Human Human -DTXSID5022699 Css NA 0.354 mg/L PBTK NA 50% Human Human -DTXSID5022699 Css NA 3.35 mg/L PBTK NA 95% Human Human -DTXSID5022699 Clint NA 37.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5022699 TK.Half.Life NA 6.29 hours 1compartment NA NA Human Human +DTXSID5022699 Css NA 2.863 mg/L 3compartmentss NA 50% Human Human +DTXSID5022699 Css NA 24.61 mg/L 3compartmentss NA 95% Human Human +DTXSID5022699 Css NA 1.696 mg/L PBTK NA 50% Human Human +DTXSID5022699 Css NA 14.24 mg/L PBTK NA 95% Human Human +DTXSID5022699 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5022699 Fup 0.031 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5022699 Vd NA 0.3261 L/kg 1compartment NA NA Rat Human +DTXSID5022699 Vd NA 0.2853 L/kg 1compartment NA NA Rat Human DTXSID5022699 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022699 TK.Half.Life NA 0.8202 hours 1compartment NA NA Rat Human -DTXSID5022699 Css NA 0.3402 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022699 Css NA 2.652 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022699 Css NA 0.1901 mg/L PBTK NA 50% Rat Human -DTXSID5022699 Css NA 1.446 mg/L PBTK NA 95% Rat Human -DTXSID5022722 Clint NA 234.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022722 Fup NA 0.0176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022722 Vd NA 6.536 L/kg 1compartment NA NA Human Human -DTXSID5022722 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5022722 TK.Half.Life NA 23.63 hours 1compartment NA NA Human Human -DTXSID5022722 Css NA 0.244 mg/L 3compartmentss NA 50% Human Human -DTXSID5022722 Css NA 1.509 mg/L 3compartmentss NA 95% Human Human -DTXSID5022722 Css NA 0.1411 mg/L PBTK NA 50% Human Human -DTXSID5022722 Css NA 0.8466 mg/L PBTK NA 95% Human Human -DTXSID5022722 Clint NA 234.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022722 Fup NA 0.0176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022722 Vd NA 5.052 L/kg 1compartment NA NA Rat Human -DTXSID5022722 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5022722 TK.Half.Life NA 4.53 hours 1compartment NA NA Rat Human -DTXSID5022722 Css NA 0.223 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022722 Css NA 1.016 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022722 Css NA 0.1204 mg/L PBTK NA 50% Rat Human -DTXSID5022722 Css NA 0.5486 mg/L PBTK NA 95% Rat Human -DTXSID5022724 Clint NA 6.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022724 Fup NA 0.0546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022724 Vd NA 1.105 L/kg 1compartment NA NA Human Human -DTXSID5022724 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5022724 TK.Half.Life NA 11.01 hours 1compartment NA NA Human Human -DTXSID5022724 Css NA 1.535 mg/L 3compartmentss NA 50% Human Human -DTXSID5022724 Css NA 10.71 mg/L 3compartmentss NA 95% Human Human -DTXSID5022724 Css NA 1.039 mg/L PBTK NA 50% Human Human -DTXSID5022724 Css NA 6.7 mg/L PBTK NA 95% Human Human -DTXSID5022724 Clint NA 6.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022724 Fup NA 0.0546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022724 Vd NA 1.087 L/kg 1compartment NA NA Rat Human +DTXSID5022699 TK.Half.Life NA 3.32 hours 1compartment NA NA Rat Human +DTXSID5022699 Css NA 0.1329 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022699 Css NA 1.24 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022699 Css NA 0.07523 mg/L PBTK NA 50% Rat Human +DTXSID5022699 Css NA 0.6974 mg/L PBTK NA 95% Rat Human +DTXSID5022722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022722 Fup 0.0105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022722 Vd NA 3.063 L/kg 1compartment NA NA Human Human +DTXSID5022722 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID5022722 TK.Half.Life NA 81.4 hours 1compartment NA NA Human Human +DTXSID5022722 Css NA 4.049 mg/L 3compartmentss NA 50% Human Human +DTXSID5022722 Css NA 25.72 mg/L 3compartmentss NA 95% Human Human +DTXSID5022722 Css NA 2.226 mg/L PBTK NA 50% Human Human +DTXSID5022722 Css NA 14.14 mg/L PBTK NA 95% Human Human +DTXSID5022722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022722 Fup 0.0105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022722 Vd NA 2.298 L/kg 1compartment NA NA Rat Human +DTXSID5022722 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID5022722 TK.Half.Life NA 12.18 hours 1compartment NA NA Rat Human +DTXSID5022722 Css NA 0.5036 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022722 Css NA 2.748 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022722 Css NA 0.2867 mg/L PBTK NA 50% Rat Human +DTXSID5022722 Css NA 1.565 mg/L PBTK NA 95% Rat Human +DTXSID5022724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022724 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022724 Vd NA 2.384 L/kg 1compartment NA NA Human Human +DTXSID5022724 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5022724 TK.Half.Life NA 8.104 hours 1compartment NA NA Human Human +DTXSID5022724 Css NA 0.2632 mg/L 3compartmentss NA 50% Human Human +DTXSID5022724 Css NA 1.761 mg/L 3compartmentss NA 95% Human Human +DTXSID5022724 Css NA 0.2452 mg/L PBTK NA 50% Human Human +DTXSID5022724 Css NA 1.365 mg/L PBTK NA 95% Human Human +DTXSID5022724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022724 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022724 Vd NA 2.393 L/kg 1compartment NA NA Rat Human DTXSID5022724 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022724 TK.Half.Life NA 6.789 hours 1compartment NA NA Rat Human -DTXSID5022724 Css NA 0.7987 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022724 Css NA 4.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022724 Css NA 0.5096 mg/L PBTK NA 50% Rat Human -DTXSID5022724 Css NA 2.58 mg/L PBTK NA 95% Rat Human -DTXSID5022774 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022774 Fup NA 0.3274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022774 Vd NA 0.4596 L/kg 1compartment NA NA Human Human +DTXSID5022724 TK.Half.Life NA 4.892 hours 1compartment NA NA Rat Human +DTXSID5022724 Css NA 0.03075 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022724 Css NA 0.1541 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022724 Css NA 0.02914 mg/L PBTK NA 50% Rat Human +DTXSID5022724 Css NA 0.1181 mg/L PBTK NA 95% Rat Human +DTXSID5022770 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022770 Fup 0.79 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5022770 Vd NA 0.617 L/kg 1compartment NA NA Human Human +DTXSID5022770 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5022770 TK.Half.Life NA 5.067 hours 1compartment NA NA Human Human +DTXSID5022770 Css NA 0.582 mg/L 3compartmentss NA 50% Human Human +DTXSID5022770 Css NA 3.439 mg/L 3compartmentss NA 95% Human Human +DTXSID5022770 Css NA 0.4539 mg/L PBTK NA 50% Human Human +DTXSID5022770 Css NA 2.212 mg/L PBTK NA 95% Human Human +DTXSID5022770 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022770 Fup 0.79 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5022770 Vd NA 0.6851 L/kg 1compartment NA NA Rat Human +DTXSID5022770 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5022770 TK.Half.Life NA 1.68 hours 1compartment NA NA Rat Human +DTXSID5022770 Css NA 0.002602 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022770 Css NA 0.01095 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022770 Css NA 0.002007 mg/L PBTK NA 50% Rat Human +DTXSID5022770 Css NA 0.007291 mg/L PBTK NA 95% Rat Human +DTXSID50227700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50227700 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50227700 Vd NA 1.62 L/kg 1compartment NA NA Human Human +DTXSID50227700 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50227700 TK.Half.Life NA 4.709 hours 1compartment NA NA Human Human +DTXSID50227700 Css NA 0.3164 mg/L 3compartmentss NA 50% Human Human +DTXSID50227700 Css NA 2.318 mg/L 3compartmentss NA 95% Human Human +DTXSID50227700 Css NA 0.2114 mg/L PBTK NA 50% Human Human +DTXSID50227700 Css NA 1.465 mg/L PBTK NA 95% Human Human +DTXSID50227700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50227700 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50227700 Vd NA 1.237 L/kg 1compartment NA NA Rat Human +DTXSID50227700 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50227700 TK.Half.Life NA 1.768 hours 1compartment NA NA Rat Human +DTXSID50227700 Css NA 0.04071 mg/L 3compartmentss NA 50% Rat Human +DTXSID50227700 Css NA 0.2355 mg/L 3compartmentss NA 95% Rat Human +DTXSID50227700 Css NA 0.02652 mg/L PBTK NA 50% Rat Human +DTXSID50227700 Css NA 0.1478 mg/L PBTK NA 95% Rat Human +DTXSID5022772 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022772 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5022772 Vd NA 0.4918 L/kg 1compartment NA NA Human Human +DTXSID5022772 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5022772 TK.Half.Life NA 4.421 hours 1compartment NA NA Human Human +DTXSID5022772 Css NA 0.6338 mg/L 3compartmentss NA 50% Human Human +DTXSID5022772 Css NA 4.068 mg/L 3compartmentss NA 95% Human Human +DTXSID5022772 Css NA 0.473 mg/L PBTK NA 50% Human Human +DTXSID5022772 Css NA 2.539 mg/L PBTK NA 95% Human Human +DTXSID5022772 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022772 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5022772 Vd NA 0.5114 L/kg 1compartment NA NA Rat Human +DTXSID5022772 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5022772 TK.Half.Life NA 1.566 hours 1compartment NA NA Rat Human +DTXSID5022772 Css NA 0.003371 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022772 Css NA 0.0222 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022772 Css NA 0.002395 mg/L PBTK NA 50% Rat Human +DTXSID5022772 Css NA 0.01308 mg/L PBTK NA 95% Rat Human +DTXSID5022774 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022774 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022774 Vd NA 0.4562 L/kg 1compartment NA NA Human Human DTXSID5022774 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022774 TK.Half.Life NA 9.081 hours 1compartment NA NA Human Human -DTXSID5022774 Css NA 2.298 mg/L 3compartmentss NA 50% Human Human -DTXSID5022774 Css NA 9.089 mg/L 3compartmentss NA 95% Human Human -DTXSID5022774 Css NA 1.633 mg/L PBTK NA 50% Human Human -DTXSID5022774 Css NA 5.722 mg/L PBTK NA 95% Human Human -DTXSID5022774 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022774 Fup NA 0.3274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022774 Vd NA 0.4697 L/kg 1compartment NA NA Rat Human +DTXSID5022774 TK.Half.Life NA 6.945 hours 1compartment NA NA Human Human +DTXSID5022774 Css NA 0.9385 mg/L 3compartmentss NA 50% Human Human +DTXSID5022774 Css NA 4.364 mg/L 3compartmentss NA 95% Human Human +DTXSID5022774 Css NA 0.6819 mg/L PBTK NA 50% Human Human +DTXSID5022774 Css NA 2.802 mg/L PBTK NA 95% Human Human +DTXSID5022774 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022774 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022774 Vd NA 0.4709 L/kg 1compartment NA NA Rat Human DTXSID5022774 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022774 TK.Half.Life NA 3.164 hours 1compartment NA NA Rat Human -DTXSID5022774 Css NA 0.6332 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022774 Css NA 2.164 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022774 Css NA 0.4265 mg/L PBTK NA 50% Rat Human -DTXSID5022774 Css NA 1.266 mg/L PBTK NA 95% Rat Human +DTXSID5022774 TK.Half.Life NA 2.443 hours 1compartment NA NA Rat Human +DTXSID5022774 Css NA 0.00508 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022774 Css NA 0.02436 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022774 Css NA 0.003535 mg/L PBTK NA 50% Rat Human +DTXSID5022774 Css NA 0.01482 mg/L PBTK NA 95% Rat Human +DTXSID50227886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50227886 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50227886 Vd NA 0.3461 L/kg 1compartment NA NA Human Human +DTXSID50227886 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50227886 TK.Half.Life NA 0.6228 hours 1compartment NA NA Human Human +DTXSID50227886 Css NA 0.1287 mg/L 3compartmentss NA 50% Human Human +DTXSID50227886 Css NA 0.971 mg/L 3compartmentss NA 95% Human Human +DTXSID50227886 Css NA 0.08388 mg/L PBTK NA 50% Human Human +DTXSID50227886 Css NA 0.6026 mg/L PBTK NA 95% Human Human +DTXSID50227886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50227886 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50227886 Vd NA 0.341 L/kg 1compartment NA NA Rat Human +DTXSID50227886 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50227886 TK.Half.Life NA 0.3442 hours 1compartment NA NA Rat Human +DTXSID50227886 Css NA 0.0167 mg/L 3compartmentss NA 50% Rat Human +DTXSID50227886 Css NA 0.09126 mg/L 3compartmentss NA 95% Rat Human +DTXSID50227886 Css NA 0.01074 mg/L PBTK NA 50% Rat Human +DTXSID50227886 Css NA 0.05569 mg/L PBTK NA 95% Rat Human DTXSID5022801 Clint 5.798 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID5022801 Fup NA 0.0282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022801 Vd NA 0.4753 L/kg 1compartment NA NA Human Human +DTXSID5022801 Fup 0.0475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022801 Vd NA 1.02 L/kg 1compartment NA NA Human Human DTXSID5022801 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5022801 TK.Half.Life NA 10.15 hours 1compartment NA NA Human Human -DTXSID5022801 Css NA 3.924 mg/L 3compartmentss NA 50% Human Human -DTXSID5022801 Css NA 31.15 mg/L 3compartmentss NA 95% Human Human -DTXSID5022801 Css NA 2.343 mg/L PBTK NA 50% Human Human -DTXSID5022801 Css NA 18.22 mg/L PBTK NA 95% Human Human +DTXSID5022801 TK.Half.Life NA 13.98 hours 1compartment NA NA Human Human +DTXSID5022801 Css NA 2.161 mg/L 3compartmentss NA 50% Human Human +DTXSID5022801 Css NA 15.3 mg/L 3compartmentss NA 95% Human Human +DTXSID5022801 Css NA 1.354 mg/L PBTK NA 50% Human Human +DTXSID5022801 Css NA 9.101 mg/L PBTK NA 95% Human Human DTXSID5022801 Clint 5.798 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID5022801 Fup NA 0.0282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022801 Vd NA 0.3768 L/kg 1compartment NA NA Rat Human +DTXSID5022801 Fup 0.0475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022801 Vd NA 0.7716 L/kg 1compartment NA NA Rat Human DTXSID5022801 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022801 TK.Half.Life NA 4.969 hours 1compartment NA NA Rat Human -DTXSID5022801 Css NA 2.018 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022801 Css NA 12.64 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022801 Css NA 1.129 mg/L PBTK NA 50% Rat Human -DTXSID5022801 Css NA 6.878 mg/L PBTK NA 95% Rat Human -DTXSID5022803 Clint NA 87.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022803 Fup NA 0.2517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022803 Vd NA 0.4389 L/kg 1compartment NA NA Human Human +DTXSID5022801 TK.Half.Life NA 5.945 hours 1compartment NA NA Rat Human +DTXSID5022801 Css NA 0.2684 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022801 Css NA 1.417 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022801 Css NA 0.1625 mg/L PBTK NA 50% Rat Human +DTXSID5022801 Css NA 0.8129 mg/L PBTK NA 95% Rat Human +DTXSID5022803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022803 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022803 Vd NA 0.6047 L/kg 1compartment NA NA Human Human DTXSID5022803 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022803 TK.Half.Life NA 0.4343 hours 1compartment NA NA Human Human -DTXSID5022803 Css NA 0.02284 mg/L 3compartmentss NA 50% Human Human -DTXSID5022803 Css NA 0.1749 mg/L 3compartmentss NA 95% Human Human -DTXSID5022803 Css NA 0.01527 mg/L PBTK NA 50% Human Human -DTXSID5022803 Css NA 0.1107 mg/L PBTK NA 95% Human Human -DTXSID5022803 Clint NA 87.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022803 Fup NA 0.2517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022803 Vd NA 0.4204 L/kg 1compartment NA NA Rat Human +DTXSID5022803 TK.Half.Life NA 0.6671 hours 1compartment NA NA Human Human +DTXSID5022803 Css NA 0.04598 mg/L 3compartmentss NA 50% Human Human +DTXSID5022803 Css NA 0.3857 mg/L 3compartmentss NA 95% Human Human +DTXSID5022803 Css NA 0.0334 mg/L PBTK NA 50% Human Human +DTXSID5022803 Css NA 0.262 mg/L PBTK NA 95% Human Human +DTXSID5022803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022803 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022803 Vd NA 0.5761 L/kg 1compartment NA NA Rat Human DTXSID5022803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022803 TK.Half.Life NA 0.1978 hours 1compartment NA NA Rat Human -DTXSID5022803 Css NA 0.01286 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022803 Css NA 0.07572 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022803 Css NA 0.008121 mg/L PBTK NA 50% Rat Human -DTXSID5022803 Css NA 0.04571 mg/L PBTK NA 95% Rat Human -DTXSID5022851 Clint NA 7.971 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022851 Fup NA 0.0473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022851 Vd NA 0.608 L/kg 1compartment NA NA Human Human +DTXSID5022803 TK.Half.Life NA 0.3231 hours 1compartment NA NA Rat Human +DTXSID5022803 Css NA 0.005724 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022803 Css NA 0.03722 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022803 Css NA 0.00416 mg/L PBTK NA 50% Rat Human +DTXSID5022803 Css NA 0.02427 mg/L PBTK NA 95% Rat Human +DTXSID5022851 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022851 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022851 Vd NA 1.328 L/kg 1compartment NA NA Human Human DTXSID5022851 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022851 TK.Half.Life NA 5.506 hours 1compartment NA NA Human Human -DTXSID5022851 Css NA 1.448 mg/L 3compartmentss NA 50% Human Human -DTXSID5022851 Css NA 11.04 mg/L 3compartmentss NA 95% Human Human -DTXSID5022851 Css NA 0.9209 mg/L PBTK NA 50% Human Human -DTXSID5022851 Css NA 6.602 mg/L PBTK NA 95% Human Human -DTXSID5022851 Clint NA 7.971 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022851 Fup NA 0.0473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022851 Vd NA 0.5828 L/kg 1compartment NA NA Rat Human +DTXSID5022851 TK.Half.Life NA 4.888 hours 1compartment NA NA Human Human +DTXSID5022851 Css NA 0.3663 mg/L 3compartmentss NA 50% Human Human +DTXSID5022851 Css NA 2.75 mg/L 3compartmentss NA 95% Human Human +DTXSID5022851 Css NA 0.2896 mg/L PBTK NA 50% Human Human +DTXSID5022851 Css NA 1.89 mg/L PBTK NA 95% Human Human +DTXSID5022851 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022851 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022851 Vd NA 1.294 L/kg 1compartment NA NA Rat Human DTXSID5022851 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022851 TK.Half.Life NA 3.358 hours 1compartment NA NA Rat Human -DTXSID5022851 Css NA 0.7754 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022851 Css NA 4.511 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022851 Css NA 0.4638 mg/L PBTK NA 50% Rat Human -DTXSID5022851 Css NA 2.549 mg/L PBTK NA 95% Rat Human +DTXSID5022851 TK.Half.Life NA 2.889 hours 1compartment NA NA Rat Human +DTXSID5022851 Css NA 0.04444 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022851 Css NA 0.2453 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022851 Css NA 0.0349 mg/L PBTK NA 50% Rat Human +DTXSID5022851 Css NA 0.1643 mg/L PBTK NA 95% Rat Human DTXSID5022855 Clint 8.567 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5022855 Fup 0.05 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID5022855 Vd NA 3.222 L/kg 1compartment NA NA Human Human DTXSID5022855 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID5022855 TK.Half.Life NA 22.31 hours 1compartment NA NA Human Human -DTXSID5022855 Css NA 0.6496 mg/L 3compartmentss NA 50% Human Human -DTXSID5022855 Css NA 5.755 mg/L 3compartmentss NA 95% Human Human -DTXSID5022855 Css NA 0.5282 mg/L PBTK NA 50% Human Human -DTXSID5022855 Css NA 3.961 mg/L PBTK NA 95% Human Human +DTXSID5022855 Css NA 0.7852 mg/L 3compartmentss NA 50% Human Human +DTXSID5022855 Css NA 6.015 mg/L 3compartmentss NA 95% Human Human +DTXSID5022855 Css NA 0.6826 mg/L PBTK NA 50% Human Human +DTXSID5022855 Css NA 5.232 mg/L PBTK NA 95% Human Human DTXSID5022855 Clint 8.567 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID5022855 Fup 0.05 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human DTXSID5022855 Vd NA 3.235 L/kg 1compartment NA NA Rat Human DTXSID5022855 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID5022855 TK.Half.Life NA 14.42 hours 1compartment NA NA Rat Human -DTXSID5022855 Css NA 0.4612 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022855 Css NA 3.375 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022855 Css NA 0.3624 mg/L PBTK NA 50% Rat Human -DTXSID5022855 Css NA 2.166 mg/L PBTK NA 95% Rat Human +DTXSID5022855 Css NA 0.09401 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022855 Css NA 0.5538 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022855 Css NA 0.08464 mg/L PBTK NA 50% Rat Human +DTXSID5022855 Css NA 0.499 mg/L PBTK NA 95% Rat Human DTXSID5022857 Clint 17.38 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID5022857 Fup NA 0.2374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022857 Vd NA 0.7878 L/kg 1compartment NA NA Human Human +DTXSID5022857 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022857 Vd NA 0.9787 L/kg 1compartment NA NA Human Human DTXSID5022857 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022857 TK.Half.Life NA 1.31 hours 1compartment NA NA Human Human -DTXSID5022857 Css NA 0.1143 mg/L 3compartmentss NA 50% Human Human -DTXSID5022857 Css NA 0.8026 mg/L 3compartmentss NA 95% Human Human -DTXSID5022857 Css NA 0.08088 mg/L PBTK NA 50% Human Human -DTXSID5022857 Css NA 0.5218 mg/L PBTK NA 95% Human Human +DTXSID5022857 TK.Half.Life NA 1.287 hours 1compartment NA NA Human Human +DTXSID5022857 Css NA 0.0708 mg/L 3compartmentss NA 50% Human Human +DTXSID5022857 Css NA 0.5281 mg/L 3compartmentss NA 95% Human Human +DTXSID5022857 Css NA 0.05372 mg/L PBTK NA 50% Human Human +DTXSID5022857 Css NA 0.3595 mg/L PBTK NA 95% Human Human DTXSID5022857 Clint 17.38 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID5022857 Fup NA 0.2374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022857 Vd NA 0.6879 L/kg 1compartment NA NA Rat Human +DTXSID5022857 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022857 Vd NA 0.8573 L/kg 1compartment NA NA Rat Human DTXSID5022857 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022857 TK.Half.Life NA 0.6233 hours 1compartment NA NA Rat Human -DTXSID5022857 Css NA 0.06236 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022857 Css NA 0.3255 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022857 Css NA 0.04186 mg/L PBTK NA 50% Rat Human -DTXSID5022857 Css NA 0.2046 mg/L PBTK NA 95% Rat Human +DTXSID5022857 TK.Half.Life NA 0.5884 hours 1compartment NA NA Rat Human +DTXSID5022857 Css NA 0.008789 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022857 Css NA 0.04948 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022857 Css NA 0.006666 mg/L PBTK NA 50% Rat Human +DTXSID5022857 Css NA 0.03378 mg/L PBTK NA 95% Rat Human DTXSID5022932 Clint 3.037 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5022932 Fup 0.0016 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5022932 Vd NA 0.1843 L/kg 1compartment NA NA Human Human +DTXSID5022932 Vd NA 0.184 L/kg 1compartment NA NA Human Human DTXSID5022932 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID5022932 TK.Half.Life NA 120.3 hours 1compartment NA NA Human Human -DTXSID5022932 Css NA 122.5 mg/L 3compartmentss NA 50% Human Human -DTXSID5022932 Css NA 882.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5022932 Css NA 69.8 mg/L PBTK NA 50% Human Human -DTXSID5022932 Css NA 510.6 mg/L PBTK NA 95% Human Human +DTXSID5022932 TK.Half.Life NA 120.1 hours 1compartment NA NA Human Human +DTXSID5022932 Css NA 124.4 mg/L 3compartmentss NA 50% Human Human +DTXSID5022932 Css NA 941.4 mg/L 3compartmentss NA 95% Human Human +DTXSID5022932 Css NA 68.4 mg/L PBTK NA 50% Human Human +DTXSID5022932 Css NA 517.8 mg/L PBTK NA 95% Human Human DTXSID5022932 Clint 3.037 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID5022932 Fup 0.0016 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5022932 Vd NA 0.1775 L/kg 1compartment NA NA Rat Human +DTXSID5022932 Vd NA 0.1774 L/kg 1compartment NA NA Rat Human DTXSID5022932 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID5022932 TK.Half.Life NA 69.43 hours 1compartment NA NA Rat Human -DTXSID5022932 Css NA 61.09 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022932 Css NA 351 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022932 Css NA 32.47 mg/L PBTK NA 50% Rat Human -DTXSID5022932 Css NA 188.9 mg/L PBTK NA 95% Rat Human +DTXSID5022932 TK.Half.Life NA 69.39 hours 1compartment NA NA Rat Human +DTXSID5022932 Css NA 12.78 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022932 Css NA 74.93 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022932 Css NA 7.278 mg/L PBTK NA 50% Rat Human +DTXSID5022932 Css NA 42.67 mg/L PBTK NA 95% Rat Human DTXSID5022934 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID5022934 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5022934 Vd NA 1.22 L/kg 1compartment NA NA Human Human DTXSID5022934 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID5022934 TK.Half.Life NA 12.3 hours 1compartment NA NA Human Human -DTXSID5022934 Css NA 1.029 mg/L 3compartmentss NA 50% Human Human -DTXSID5022934 Css NA 6.856 mg/L 3compartmentss NA 95% Human Human -DTXSID5022934 Css NA 0.9256 mg/L PBTK NA 50% Human Human -DTXSID5022934 Css NA 4.556 mg/L PBTK NA 95% Human Human +DTXSID5022934 Css NA 0.8914 mg/L 3compartmentss NA 50% Human Human +DTXSID5022934 Css NA 4.445 mg/L 3compartmentss NA 95% Human Human +DTXSID5022934 Css NA 0.8558 mg/L PBTK NA 50% Human Human +DTXSID5022934 Css NA 4.267 mg/L PBTK NA 95% Human Human DTXSID5022934 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID5022934 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5022934 Vd NA 1.245 L/kg 1compartment NA NA Rat Human DTXSID5022934 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5022934 TK.Half.Life NA 3.239 hours 1compartment NA NA Rat Human -DTXSID5022934 Css NA 0.2393 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022934 Css NA 1.401 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022934 Css NA 0.204 mg/L PBTK NA 50% Rat Human -DTXSID5022934 Css NA 0.8602 mg/L PBTK NA 95% Rat Human -DTXSID5022938 Clint NA 160.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022938 Fup NA 0.0065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022938 Vd NA 187.3 L/kg 1compartment NA NA Human Human -DTXSID5022938 Days.Css NA 176 Days PBTK NA NA Human Human -DTXSID5022938 TK.Half.Life NA 759.7 hours 1compartment NA NA Human Human -DTXSID5022938 Css NA 0.0137 mg/L 3compartmentss NA 50% Human Human -DTXSID5022938 Css NA 0.0856 mg/L 3compartmentss NA 95% Human Human -DTXSID5022938 Css NA 0.3348 mg/L PBTK NA 50% Human Human -DTXSID5022938 Css NA 1.887 mg/L PBTK NA 95% Human Human -DTXSID5022938 Clint NA 160.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022938 Fup NA 0.0065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022938 Vd NA 165.1 L/kg 1compartment NA NA Rat Human -DTXSID5022938 Days.Css NA 119 Days PBTK NA NA Rat Human -DTXSID5022938 TK.Half.Life NA 120.4 hours 1compartment NA NA Rat Human -DTXSID5022938 Css NA 0.006944 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022938 Css NA 0.03115 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022938 Css NA 0.1832 mg/L PBTK NA 50% Rat Human -DTXSID5022938 Css NA 0.7996 mg/L PBTK NA 95% Rat Human -DTXSID5022980 Clint NA 61.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022980 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022980 Vd NA 1.717 L/kg 1compartment NA NA Human Human +DTXSID5022934 Css NA 0.03206 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022934 Css NA 0.1295 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022934 Css NA 0.03169 mg/L PBTK NA 50% Rat Human +DTXSID5022934 Css NA 0.128 mg/L PBTK NA 95% Rat Human +DTXSID5022938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022938 Fup 0.0314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022938 Vd NA 38.51 L/kg 1compartment NA NA Human Human +DTXSID5022938 Days.Css NA 279 Days PBTK NA NA Human Human +DTXSID5022938 TK.Half.Life NA 1132 hours 1compartment NA NA Human Human +DTXSID5022938 Css NA 0.3105 mg/L 3compartmentss NA 50% Human Human +DTXSID5022938 Css NA 2.091 mg/L 3compartmentss NA 95% Human Human +DTXSID5022938 Css NA 1.306 mg/L PBTK NA 50% Human Human +DTXSID5022938 Css NA 7.958 mg/L PBTK NA 95% Human Human +DTXSID5022938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022938 Fup 0.0314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022938 Vd NA 32.12 L/kg 1compartment NA NA Rat Human +DTXSID5022938 Days.Css NA 171 Days PBTK NA NA Rat Human +DTXSID5022938 TK.Half.Life NA 161.2 hours 1compartment NA NA Rat Human +DTXSID5022938 Css NA 0.003056 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022938 Css NA 0.01842 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022938 Css NA 0.01342 mg/L PBTK NA 50% Rat Human +DTXSID5022938 Css NA 0.07884 mg/L PBTK NA 95% Rat Human +DTXSID5022980 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022980 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022980 Vd NA 3.251 L/kg 1compartment NA NA Human Human DTXSID5022980 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022980 TK.Half.Life NA 2.115 hours 1compartment NA NA Human Human -DTXSID5022980 Css NA 0.07852 mg/L 3compartmentss NA 50% Human Human -DTXSID5022980 Css NA 0.8034 mg/L 3compartmentss NA 95% Human Human -DTXSID5022980 Css NA 0.06024 mg/L PBTK NA 50% Human Human -DTXSID5022980 Css NA 0.5417 mg/L PBTK NA 95% Human Human -DTXSID5022980 Clint NA 61.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022980 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022980 Vd NA 1.683 L/kg 1compartment NA NA Rat Human +DTXSID5022980 TK.Half.Life NA 3.511 hours 1compartment NA NA Human Human +DTXSID5022980 Css NA 0.05624 mg/L 3compartmentss NA 50% Human Human +DTXSID5022980 Css NA 0.5897 mg/L 3compartmentss NA 95% Human Human +DTXSID5022980 Css NA 0.06004 mg/L PBTK NA 50% Human Human +DTXSID5022980 Css NA 0.4819 mg/L PBTK NA 95% Human Human +DTXSID5022980 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022980 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022980 Vd NA 3.234 L/kg 1compartment NA NA Rat Human DTXSID5022980 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022980 TK.Half.Life NA 1.133 hours 1compartment NA NA Rat Human -DTXSID5022980 Css NA 0.0449 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022980 Css NA 0.3568 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022980 Css NA 0.03284 mg/L PBTK NA 50% Rat Human -DTXSID5022980 Css NA 0.229 mg/L PBTK NA 95% Rat Human -DTXSID5022982 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022982 Fup NA 0.2675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022982 Vd NA 0.3812 L/kg 1compartment NA NA Human Human +DTXSID5022980 TK.Half.Life NA 1.966 hours 1compartment NA NA Rat Human +DTXSID5022980 Css NA 0.007173 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022980 Css NA 0.06052 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022980 Css NA 0.007735 mg/L PBTK NA 50% Rat Human +DTXSID5022980 Css NA 0.04988 mg/L PBTK NA 95% Rat Human +DTXSID5022982 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022982 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022982 Vd NA 0.4429 L/kg 1compartment NA NA Human Human DTXSID5022982 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022982 TK.Half.Life NA 9.226 hours 1compartment NA NA Human Human -DTXSID5022982 Css NA 2.964 mg/L 3compartmentss NA 50% Human Human -DTXSID5022982 Css NA 11.38 mg/L 3compartmentss NA 95% Human Human -DTXSID5022982 Css NA 1.972 mg/L PBTK NA 50% Human Human -DTXSID5022982 Css NA 6.941 mg/L PBTK NA 95% Human Human -DTXSID5022982 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022982 Fup NA 0.2675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022982 Vd NA 0.384 L/kg 1compartment NA NA Rat Human +DTXSID5022982 TK.Half.Life NA 0.9061 hours 1compartment NA NA Human Human +DTXSID5022982 Css NA 0.0846 mg/L 3compartmentss NA 50% Human Human +DTXSID5022982 Css NA 0.6596 mg/L 3compartmentss NA 95% Human Human +DTXSID5022982 Css NA 0.05926 mg/L PBTK NA 50% Human Human +DTXSID5022982 Css NA 0.4251 mg/L PBTK NA 95% Human Human +DTXSID5022982 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022982 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022982 Vd NA 0.4481 L/kg 1compartment NA NA Rat Human DTXSID5022982 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022982 TK.Half.Life NA 3.167 hours 1compartment NA NA Rat Human -DTXSID5022982 Css NA 0.8318 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022982 Css NA 2.596 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022982 Css NA 0.5214 mg/L PBTK NA 50% Rat Human -DTXSID5022982 Css NA 1.482 mg/L PBTK NA 95% Rat Human -DTXSID5022984 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5022982 TK.Half.Life NA 0.5082 hours 1compartment NA NA Rat Human +DTXSID5022982 Css NA 0.0007892 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022982 Css NA 0.005275 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022982 Css NA 0.000529 mg/L PBTK NA 50% Rat Human +DTXSID5022982 Css NA 0.003187 mg/L PBTK NA 95% Rat Human +DTXSID5022984 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5022984 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5022984 Vd NA 0.4927 L/kg 1compartment NA NA Human Human DTXSID5022984 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022984 TK.Half.Life NA 0.6365 hours 1compartment NA NA Human Human -DTXSID5022984 Css NA 0.1064 mg/L 3compartmentss NA 50% Human Human -DTXSID5022984 Css NA 0.7973 mg/L 3compartmentss NA 95% Human Human -DTXSID5022984 Css NA 0.07892 mg/L PBTK NA 50% Human Human -DTXSID5022984 Css NA 0.5287 mg/L PBTK NA 95% Human Human -DTXSID5022984 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5022984 TK.Half.Life NA 0.6123 hours 1compartment NA NA Human Human +DTXSID5022984 Css NA 0.04534 mg/L 3compartmentss NA 50% Human Human +DTXSID5022984 Css NA 0.4229 mg/L 3compartmentss NA 95% Human Human +DTXSID5022984 Css NA 0.03378 mg/L PBTK NA 50% Human Human +DTXSID5022984 Css NA 0.2814 mg/L PBTK NA 95% Human Human +DTXSID5022984 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5022984 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5022984 Vd NA 0.4606 L/kg 1compartment NA NA Rat Human DTXSID5022984 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022984 TK.Half.Life NA 0.3631 hours 1compartment NA NA Rat Human -DTXSID5022984 Css NA 0.0593 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022984 Css NA 0.4335 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022984 Css NA 0.04175 mg/L PBTK NA 50% Rat Human -DTXSID5022984 Css NA 0.254 mg/L PBTK NA 95% Rat Human -DTXSID5022986 Clint NA 2.418 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022986 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5022986 Vd NA 1.862 L/kg 1compartment NA NA Human Human -DTXSID5022986 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5022986 TK.Half.Life NA 2.947 hours 1compartment NA NA Human Human -DTXSID5022986 Css NA 0.1441 mg/L 3compartmentss NA 50% Human Human -DTXSID5022986 Css NA 1.236 mg/L 3compartmentss NA 95% Human Human -DTXSID5022986 Css NA 0.1442 mg/L PBTK NA 50% Human Human -DTXSID5022986 Css NA 0.9134 mg/L PBTK NA 95% Human Human -DTXSID5022986 Clint NA 2.418 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022986 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5022986 Vd NA 1.906 L/kg 1compartment NA NA Rat Human +DTXSID5022984 TK.Half.Life NA 0.3469 hours 1compartment NA NA Rat Human +DTXSID5022984 Css NA 0.0004684 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022984 Css NA 0.004834 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022984 Css NA 0.0003288 mg/L PBTK NA 50% Rat Human +DTXSID5022984 Css NA 0.002917 mg/L PBTK NA 95% Rat Human +DTXSID5022986 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022986 Fup 0.772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5022986 Vd NA 1.568 L/kg 1compartment NA NA Human Human +DTXSID5022986 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5022986 TK.Half.Life NA 13.14 hours 1compartment NA NA Human Human +DTXSID5022986 Css NA 0.6768 mg/L 3compartmentss NA 50% Human Human +DTXSID5022986 Css NA 4.668 mg/L 3compartmentss NA 95% Human Human +DTXSID5022986 Css NA 0.6465 mg/L PBTK NA 50% Human Human +DTXSID5022986 Css NA 3.14 mg/L PBTK NA 95% Human Human +DTXSID5022986 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022986 Fup 0.772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5022986 Vd NA 1.602 L/kg 1compartment NA NA Rat Human DTXSID5022986 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5022986 TK.Half.Life NA 1.591 hours 1compartment NA NA Rat Human -DTXSID5022986 Css NA 0.06024 mg/L 3compartmentss NA 50% Rat Human -DTXSID5022986 Css NA 0.4404 mg/L 3compartmentss NA 95% Rat Human -DTXSID5022986 Css NA 0.06139 mg/L PBTK NA 50% Rat Human -DTXSID5022986 Css NA 0.2931 mg/L PBTK NA 95% Rat Human -DTXSID5023031 Clint NA 2.204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023031 Fup NA 0.7279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023031 Vd NA 0.6875 L/kg 1compartment NA NA Human Human +DTXSID5022986 TK.Half.Life NA 4.575 hours 1compartment NA NA Rat Human +DTXSID5022986 Css NA 0.006965 mg/L 3compartmentss NA 50% Rat Human +DTXSID5022986 Css NA 0.07166 mg/L 3compartmentss NA 95% Rat Human +DTXSID5022986 Css NA 0.006428 mg/L PBTK NA 50% Rat Human +DTXSID5022986 Css NA 0.05161 mg/L PBTK NA 95% Rat Human +DTXSID5023031 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023031 Fup 0.732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023031 Vd NA 0.667 L/kg 1compartment NA NA Human Human DTXSID5023031 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023031 TK.Half.Life NA 1.584 hours 1compartment NA NA Human Human -DTXSID5023031 Css NA 0.24 mg/L 3compartmentss NA 50% Human Human -DTXSID5023031 Css NA 1.724 mg/L 3compartmentss NA 95% Human Human -DTXSID5023031 Css NA 0.1921 mg/L PBTK NA 50% Human Human -DTXSID5023031 Css NA 1.13 mg/L PBTK NA 95% Human Human -DTXSID5023031 Clint NA 2.204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023031 Fup NA 0.7279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023031 Vd NA 0.7116 L/kg 1compartment NA NA Rat Human +DTXSID5023031 TK.Half.Life NA 5.899 hours 1compartment NA NA Human Human +DTXSID5023031 Css NA 1.035 mg/L 3compartmentss NA 50% Human Human +DTXSID5023031 Css NA 6.677 mg/L 3compartmentss NA 95% Human Human +DTXSID5023031 Css NA 0.8311 mg/L PBTK NA 50% Human Human +DTXSID5023031 Css NA 4.195 mg/L PBTK NA 95% Human Human +DTXSID5023031 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023031 Fup 0.732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023031 Vd NA 0.6941 L/kg 1compartment NA NA Rat Human DTXSID5023031 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023031 TK.Half.Life NA 0.8587 hours 1compartment NA NA Rat Human -DTXSID5023031 Css NA 0.1026 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023031 Css NA 0.6911 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023031 Css NA 0.08036 mg/L PBTK NA 50% Rat Human -DTXSID5023031 Css NA 0.4103 mg/L PBTK NA 95% Rat Human -DTXSID5023033 Clint NA 12.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5023031 TK.Half.Life NA 2.091 hours 1compartment NA NA Rat Human +DTXSID5023031 Css NA 0.06154 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023031 Css NA 0.3829 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023031 Css NA 0.04962 mg/L PBTK NA 50% Rat Human +DTXSID5023031 Css NA 0.2342 mg/L PBTK NA 95% Rat Human +DTXSID5023033 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5023033 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5023033 Vd NA 1.882 L/kg 1compartment NA NA Human Human +DTXSID5023033 Vd NA 2.508 L/kg 1compartment NA NA Human Human DTXSID5023033 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023033 TK.Half.Life NA 4.64 hours 1compartment NA NA Human Human -DTXSID5023033 Css NA 0.213 mg/L 3compartmentss NA 50% Human Human -DTXSID5023033 Css NA 1.31 mg/L 3compartmentss NA 95% Human Human -DTXSID5023033 Css NA 0.1561 mg/L PBTK NA 50% Human Human -DTXSID5023033 Css NA 0.9134 mg/L PBTK NA 95% Human Human -DTXSID5023033 Clint NA 12.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5023033 TK.Half.Life NA 6.123 hours 1compartment NA NA Human Human +DTXSID5023033 Css NA 0.2004 mg/L 3compartmentss NA 50% Human Human +DTXSID5023033 Css NA 1.263 mg/L 3compartmentss NA 95% Human Human +DTXSID5023033 Css NA 0.1456 mg/L PBTK NA 50% Human Human +DTXSID5023033 Css NA 0.8937 mg/L PBTK NA 95% Human Human +DTXSID5023033 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5023033 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5023033 Vd NA 1.467 L/kg 1compartment NA NA Rat Human +DTXSID5023033 Vd NA 1.915 L/kg 1compartment NA NA Rat Human DTXSID5023033 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023033 TK.Half.Life NA 1.653 hours 1compartment NA NA Rat Human -DTXSID5023033 Css NA 0.1141 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023033 Css NA 0.5133 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023033 Css NA 0.08057 mg/L PBTK NA 50% Rat Human -DTXSID5023033 Css NA 0.3415 mg/L PBTK NA 95% Rat Human -DTXSID5023035 Clint NA 14.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5023033 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human +DTXSID5023033 Css NA 0.02511 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023033 Css NA 0.1241 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023033 Css NA 0.01828 mg/L PBTK NA 50% Rat Human +DTXSID5023033 Css NA 0.08687 mg/L PBTK NA 95% Rat Human +DTXSID5023035 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5023035 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5023035 Vd NA 0.3197 L/kg 1compartment NA NA Human Human -DTXSID5023035 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023035 TK.Half.Life NA 0.9875 hours 1compartment NA NA Human Human -DTXSID5023035 Css NA 0.2161 mg/L 3compartmentss NA 50% Human Human -DTXSID5023035 Css NA 1.533 mg/L 3compartmentss NA 95% Human Human -DTXSID5023035 Css NA 0.1232 mg/L PBTK NA 50% Human Human -DTXSID5023035 Css NA 0.8743 mg/L PBTK NA 95% Human Human -DTXSID5023035 Clint NA 14.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5023035 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5023035 TK.Half.Life NA 17.29 hours 1compartment NA NA Human Human +DTXSID5023035 Css NA 8.006 mg/L 3compartmentss NA 50% Human Human +DTXSID5023035 Css NA 35.62 mg/L 3compartmentss NA 95% Human Human +DTXSID5023035 Css NA 4.403 mg/L PBTK NA 50% Human Human +DTXSID5023035 Css NA 19.59 mg/L PBTK NA 95% Human Human +DTXSID5023035 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5023035 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5023035 Vd NA 0.3101 L/kg 1compartment NA NA Rat Human DTXSID5023035 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023035 TK.Half.Life NA 0.5672 hours 1compartment NA NA Rat Human -DTXSID5023035 Css NA 0.2204 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023035 Css NA 1.243 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023035 Css NA 0.1172 mg/L PBTK NA 50% Rat Human -DTXSID5023035 Css NA 0.6633 mg/L PBTK NA 95% Rat Human +DTXSID5023035 TK.Half.Life NA 5.705 hours 1compartment NA NA Rat Human +DTXSID5023035 Css NA 0.1853 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023035 Css NA 1.088 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023035 Css NA 0.1033 mg/L PBTK NA 50% Rat Human +DTXSID5023035 Css NA 0.6149 mg/L PBTK NA 95% Rat Human +DTXSID5023037 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023037 Fup 0.0281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023037 Vd NA 2.051 L/kg 1compartment NA NA Human Human +DTXSID5023037 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5023037 TK.Half.Life NA 16.95 hours 1compartment NA NA Human Human +DTXSID5023037 Css NA 1.197 mg/L 3compartmentss NA 50% Human Human +DTXSID5023037 Css NA 9.404 mg/L 3compartmentss NA 95% Human Human +DTXSID5023037 Css NA 0.7737 mg/L PBTK NA 50% Human Human +DTXSID5023037 Css NA 5.787 mg/L PBTK NA 95% Human Human +DTXSID5023037 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023037 Fup 0.0281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023037 Vd NA 1.528 L/kg 1compartment NA NA Rat Human +DTXSID5023037 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5023037 TK.Half.Life NA 5.352 hours 1compartment NA NA Rat Human +DTXSID5023037 Css NA 0.1522 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023037 Css NA 0.9949 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023037 Css NA 0.09612 mg/L PBTK NA 50% Rat Human +DTXSID5023037 Css NA 0.6027 mg/L PBTK NA 95% Rat Human DTXSID5023039 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID5023039 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5023039 Vd NA 2.437 L/kg 1compartment NA NA Human Human DTXSID5023039 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID5023039 TK.Half.Life NA 18.79 hours 1compartment NA NA Human Human -DTXSID5023039 Css NA 0.4388 mg/L 3compartmentss NA 50% Human Human -DTXSID5023039 Css NA 2.88 mg/L 3compartmentss NA 95% Human Human -DTXSID5023039 Css NA 0.4058 mg/L PBTK NA 50% Human Human -DTXSID5023039 Css NA 1.907 mg/L PBTK NA 95% Human Human +DTXSID5023039 Css NA 0.6011 mg/L 3compartmentss NA 50% Human Human +DTXSID5023039 Css NA 2.872 mg/L 3compartmentss NA 95% Human Human +DTXSID5023039 Css NA 0.601 mg/L PBTK NA 50% Human Human +DTXSID5023039 Css NA 2.872 mg/L PBTK NA 95% Human Human DTXSID5023039 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID5023039 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5023039 Vd NA 2.451 L/kg 1compartment NA NA Rat Human DTXSID5023039 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5023039 TK.Half.Life NA 6.436 hours 1compartment NA NA Rat Human -DTXSID5023039 Css NA 0.2177 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023039 Css NA 1.383 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023039 Css NA 0.1975 mg/L PBTK NA 50% Rat Human -DTXSID5023039 Css NA 0.8629 mg/L PBTK NA 95% Rat Human +DTXSID5023039 Css NA 0.005682 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023039 Css NA 0.04265 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023039 Css NA 0.005706 mg/L PBTK NA 50% Rat Human +DTXSID5023039 Css NA 0.04336 mg/L PBTK NA 95% Rat Human DTXSID5023081 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5023081 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023081 Vd NA 0.5442 L/kg 1compartment NA NA Human Human +DTXSID5023081 Vd NA 0.5389 L/kg 1compartment NA NA Human Human DTXSID5023081 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023081 TK.Half.Life NA 3.522 hours 1compartment NA NA Human Human -DTXSID5023081 Css NA 0.91 mg/L 3compartmentss NA 50% Human Human -DTXSID5023081 Css NA 5.667 mg/L 3compartmentss NA 95% Human Human -DTXSID5023081 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID5023081 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID5023081 TK.Half.Life NA 3.488 hours 1compartment NA NA Human Human +DTXSID5023081 Css NA 0.7688 mg/L 3compartmentss NA 50% Human Human +DTXSID5023081 Css NA 5.209 mg/L 3compartmentss NA 95% Human Human +DTXSID5023081 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID5023081 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID5023081 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5023081 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023081 Vd NA 0.5836 L/kg 1compartment NA NA Rat Human +DTXSID5023081 Vd NA 0.5792 L/kg 1compartment NA NA Rat Human DTXSID5023081 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023081 TK.Half.Life NA 1.287 hours 1compartment NA NA Rat Human -DTXSID5023081 Css NA 0.2307 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023081 Css NA 1.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023081 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID5023081 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5023085 Clint NA 0.008081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023085 Fup NA 0.1146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023085 Vd NA 0.2814 L/kg 1compartment NA NA Human Human -DTXSID5023085 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5023085 TK.Half.Life NA 15.69 hours 1compartment NA NA Human Human -DTXSID5023085 Css NA 8.591 mg/L 3compartmentss NA 50% Human Human -DTXSID5023085 Css NA 39.93 mg/L 3compartmentss NA 95% Human Human -DTXSID5023085 Css NA 5.318 mg/L PBTK NA 50% Human Human -DTXSID5023085 Css NA 23.46 mg/L PBTK NA 95% Human Human -DTXSID5023085 Clint NA 0.008081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023085 Fup NA 0.1146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023085 Vd NA 0.2751 L/kg 1compartment NA NA Rat Human +DTXSID5023081 TK.Half.Life NA 1.277 hours 1compartment NA NA Rat Human +DTXSID5023081 Css NA 0.0142 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023081 Css NA 0.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023081 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID5023081 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID5023085 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023085 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023085 Vd NA 0.3984 L/kg 1compartment NA NA Human Human +DTXSID5023085 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5023085 TK.Half.Life NA 0.5263 hours 1compartment NA NA Human Human +DTXSID5023085 Css NA 0.06774 mg/L 3compartmentss NA 50% Human Human +DTXSID5023085 Css NA 0.5252 mg/L 3compartmentss NA 95% Human Human +DTXSID5023085 Css NA 0.04628 mg/L PBTK NA 50% Human Human +DTXSID5023085 Css NA 0.3372 mg/L PBTK NA 95% Human Human +DTXSID5023085 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023085 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023085 Vd NA 0.3956 L/kg 1compartment NA NA Rat Human DTXSID5023085 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023085 TK.Half.Life NA 5.259 hours 1compartment NA NA Rat Human -DTXSID5023085 Css NA 2.428 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023085 Css NA 9.815 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023085 Css NA 1.406 mg/L PBTK NA 50% Rat Human -DTXSID5023085 Css NA 5.4 mg/L PBTK NA 95% Rat Human -DTXSID5023089 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023089 Fup NA 0.6828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023089 Vd NA 3.17 L/kg 1compartment NA NA Human Human -DTXSID5023089 Days.Css NA 2635 Days PBTK NA NA Human Human -DTXSID5023089 TK.Half.Life NA 9607 hours 1compartment NA NA Human Human -DTXSID5023089 Css NA 339 mg/L 3compartmentss NA 50% Human Human -DTXSID5023089 Css NA 935.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5023089 Css NA 239.4 mg/L PBTK NA 50% Human Human -DTXSID5023089 Css NA 610.4 mg/L PBTK NA 95% Human Human -DTXSID5023089 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023089 Fup NA 0.6828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023089 Vd NA 2.39 L/kg 1compartment NA NA Rat Human -DTXSID5023089 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID5023089 TK.Half.Life NA 594 hours 1compartment NA NA Rat Human -DTXSID5023089 Css NA 91.86 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023089 Css NA 205 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023089 Css NA 62.18 mg/L PBTK NA 50% Rat Human -DTXSID5023089 Css NA 124.7 mg/L PBTK NA 95% Rat Human -DTXSID5023110 Clint NA 656.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5023085 TK.Half.Life NA 0.2752 hours 1compartment NA NA Rat Human +DTXSID5023085 Css NA 0.00863 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023085 Css NA 0.04779 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023085 Css NA 0.00582 mg/L PBTK NA 50% Rat Human +DTXSID5023085 Css NA 0.03053 mg/L PBTK NA 95% Rat Human +DTXSID5023089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023089 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023089 Vd NA 2.4 L/kg 1compartment NA NA Human Human +DTXSID5023089 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5023089 TK.Half.Life NA 6.966 hours 1compartment NA NA Human Human +DTXSID5023089 Css NA 0.2856 mg/L 3compartmentss NA 50% Human Human +DTXSID5023089 Css NA 2.133 mg/L 3compartmentss NA 95% Human Human +DTXSID5023089 Css NA 0.2071 mg/L PBTK NA 50% Human Human +DTXSID5023089 Css NA 1.448 mg/L PBTK NA 95% Human Human +DTXSID5023089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023089 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023089 Vd NA 1.92 L/kg 1compartment NA NA Rat Human +DTXSID5023089 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5023089 TK.Half.Life NA 2.358 hours 1compartment NA NA Rat Human +DTXSID5023089 Css NA 0.03626 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023089 Css NA 0.2021 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023089 Css NA 0.02615 mg/L PBTK NA 50% Rat Human +DTXSID5023089 Css NA 0.1345 mg/L PBTK NA 95% Rat Human +DTXSID5023110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5023110 Fup 0.01 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID5023110 Vd NA 1.987 L/kg 1compartment NA NA Human Human +DTXSID5023110 Vd NA 0.5087 L/kg 1compartment NA NA Human Human DTXSID5023110 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023110 TK.Half.Life NA 2.629 hours 1compartment NA NA Human Human -DTXSID5023110 Css NA 0.08396 mg/L 3compartmentss NA 50% Human Human -DTXSID5023110 Css NA 0.7256 mg/L 3compartmentss NA 95% Human Human -DTXSID5023110 Css NA 0.05275 mg/L PBTK NA 50% Human Human -DTXSID5023110 Css NA 0.4374 mg/L PBTK NA 95% Human Human -DTXSID5023110 Clint NA 656.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5023110 TK.Half.Life NA 8.166 hours 1compartment NA NA Human Human +DTXSID5023110 Css NA 2.197 mg/L 3compartmentss NA 50% Human Human +DTXSID5023110 Css NA 21.43 mg/L 3compartmentss NA 95% Human Human +DTXSID5023110 Css NA 1.476 mg/L PBTK NA 50% Human Human +DTXSID5023110 Css NA 14.39 mg/L PBTK NA 95% Human Human +DTXSID5023110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5023110 Fup 0.01 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID5023110 Vd NA 1.471 L/kg 1compartment NA NA Rat Human +DTXSID5023110 Vd NA 0.387 L/kg 1compartment NA NA Rat Human DTXSID5023110 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023110 TK.Half.Life NA 0.8532 hours 1compartment NA NA Rat Human -DTXSID5023110 Css NA 0.04804 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023110 Css NA 0.3516 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023110 Css NA 0.02828 mg/L PBTK NA 50% Rat Human -DTXSID5023110 Css NA 0.1974 mg/L PBTK NA 95% Rat Human -DTXSID5023114 Clint NA 772.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023114 Fup NA 0.5296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023114 Vd NA 1.18 L/kg 1compartment NA NA Human Human -DTXSID5023114 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023114 TK.Half.Life NA 0.7594 hours 1compartment NA NA Human Human -DTXSID5023114 Css NA 0.00114 mg/L 3compartmentss NA 50% Human Human -DTXSID5023114 Css NA 0.01194 mg/L 3compartmentss NA 95% Human Human -DTXSID5023114 Css NA 0.0009314 mg/L PBTK NA 50% Human Human -DTXSID5023114 Css NA 0.00843 mg/L PBTK NA 95% Human Human -DTXSID5023114 Clint NA 772.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023114 Fup NA 0.5296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023114 Vd NA 1.049 L/kg 1compartment NA NA Rat Human +DTXSID5023110 TK.Half.Life NA 4.049 hours 1compartment NA NA Rat Human +DTXSID5023110 Css NA 0.1016 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023110 Css NA 1.114 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023110 Css NA 0.06936 mg/L PBTK NA 50% Rat Human +DTXSID5023110 Css NA 0.764 mg/L PBTK NA 95% Rat Human +DTXSID5023114 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023114 Fup 0.509 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023114 Vd NA 1.154 L/kg 1compartment NA NA Human Human +DTXSID5023114 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5023114 TK.Half.Life NA 16 hours 1compartment NA NA Human Human +DTXSID5023114 Css NA 1.399 mg/L 3compartmentss NA 50% Human Human +DTXSID5023114 Css NA 7.669 mg/L 3compartmentss NA 95% Human Human +DTXSID5023114 Css NA 1.154 mg/L PBTK NA 50% Human Human +DTXSID5023114 Css NA 4.989 mg/L PBTK NA 95% Human Human +DTXSID5023114 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023114 Fup 0.509 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023114 Vd NA 1.025 L/kg 1compartment NA NA Rat Human DTXSID5023114 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023114 TK.Half.Life NA 0.2931 hours 1compartment NA NA Rat Human -DTXSID5023114 Css NA 0.0006205 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023114 Css NA 0.005281 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023114 Css NA 0.0004946 mg/L PBTK NA 50% Rat Human -DTXSID5023114 Css NA 0.003668 mg/L PBTK NA 95% Rat Human +DTXSID5023114 TK.Half.Life NA 4.533 hours 1compartment NA NA Rat Human +DTXSID5023114 Css NA 0.08676 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023114 Css NA 0.4389 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023114 Css NA 0.07174 mg/L PBTK NA 50% Rat Human +DTXSID5023114 Css NA 0.2761 mg/L PBTK NA 95% Rat Human DTXSID5023166 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5023166 Fup NA 0.1107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023166 Vd NA 0.2635 L/kg 1compartment NA NA Human Human +DTXSID5023166 Vd NA 0.2238 L/kg 1compartment NA NA Human Human DTXSID5023166 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5023166 TK.Half.Life NA 15.4 hours 1compartment NA NA Human Human -DTXSID5023166 Css NA 9.18 mg/L 3compartmentss NA 50% Human Human -DTXSID5023166 Css NA 41.52 mg/L 3compartmentss NA 95% Human Human -DTXSID5023166 Css NA 5.64 mg/L PBTK NA 50% Human Human -DTXSID5023166 Css NA 24.54 mg/L PBTK NA 95% Human Human +DTXSID5023166 TK.Half.Life NA 13.08 hours 1compartment NA NA Human Human +DTXSID5023166 Css NA 7.864 mg/L 3compartmentss NA 50% Human Human +DTXSID5023166 Css NA 37.05 mg/L 3compartmentss NA 95% Human Human +DTXSID5023166 Css NA 4.745 mg/L PBTK NA 50% Human Human +DTXSID5023166 Css NA 21.48 mg/L PBTK NA 95% Human Human DTXSID5023166 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5023166 Fup NA 0.1107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023166 Vd NA 0.2631 L/kg 1compartment NA NA Rat Human +DTXSID5023166 Vd NA 0.2279 L/kg 1compartment NA NA Rat Human DTXSID5023166 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023166 TK.Half.Life NA 5.239 hours 1compartment NA NA Rat Human -DTXSID5023166 Css NA 2.564 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023166 Css NA 9.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023166 Css NA 1.478 mg/L PBTK NA 50% Rat Human -DTXSID5023166 Css NA 5.454 mg/L PBTK NA 95% Rat Human -DTXSID5023243 Clint NA 55.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023243 Fup NA 0.0034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023243 Vd NA 0.4256 L/kg 1compartment NA NA Human Human +DTXSID5023166 TK.Half.Life NA 4.539 hours 1compartment NA NA Rat Human +DTXSID5023166 Css NA 0.1451 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023166 Css NA 0.9437 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023166 Css NA 0.08314 mg/L PBTK NA 50% Rat Human +DTXSID5023166 Css NA 0.5347 mg/L PBTK NA 95% Rat Human +DTXSID5023243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023243 Fup 0.0131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023243 Vd NA 0.8135 L/kg 1compartment NA NA Human Human DTXSID5023243 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023243 TK.Half.Life NA 7.273 hours 1compartment NA NA Human Human -DTXSID5023243 Css NA 3.056 mg/L 3compartmentss NA 50% Human Human -DTXSID5023243 Css NA 27.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5023243 Css NA 1.801 mg/L PBTK NA 50% Human Human -DTXSID5023243 Css NA 16.18 mg/L PBTK NA 95% Human Human -DTXSID5023243 Clint NA 55.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023243 Fup NA 0.0034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023243 Vd NA 0.3291 L/kg 1compartment NA NA Rat Human +DTXSID5023243 TK.Half.Life NA 10.1 hours 1compartment NA NA Human Human +DTXSID5023243 Css NA 2.078 mg/L 3compartmentss NA 50% Human Human +DTXSID5023243 Css NA 20.58 mg/L 3compartmentss NA 95% Human Human +DTXSID5023243 Css NA 1.268 mg/L PBTK NA 50% Human Human +DTXSID5023243 Css NA 11.99 mg/L PBTK NA 95% Human Human +DTXSID5023243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023243 Fup 0.0131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023243 Vd NA 0.6151 L/kg 1compartment NA NA Rat Human DTXSID5023243 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023243 TK.Half.Life NA 3.751 hours 1compartment NA NA Rat Human -DTXSID5023243 Css NA 1.822 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023243 Css NA 12.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023243 Css NA 0.9976 mg/L PBTK NA 50% Rat Human -DTXSID5023243 Css NA 6.659 mg/L PBTK NA 95% Rat Human -DTXSID5023247 Clint NA 1.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023247 Fup NA 0.1338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023247 Vd NA 1.204 L/kg 1compartment NA NA Human Human -DTXSID5023247 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5023247 TK.Half.Life NA 20.55 hours 1compartment NA NA Human Human -DTXSID5023247 Css NA 2.394 mg/L 3compartmentss NA 50% Human Human -DTXSID5023247 Css NA 12.35 mg/L 3compartmentss NA 95% Human Human -DTXSID5023247 Css NA 1.611 mg/L PBTK NA 50% Human Human -DTXSID5023247 Css NA 7.604 mg/L PBTK NA 95% Human Human -DTXSID5023247 Clint NA 1.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023247 Fup NA 0.1338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023247 Vd NA 0.9475 L/kg 1compartment NA NA Rat Human +DTXSID5023243 TK.Half.Life NA 4.722 hours 1compartment NA NA Rat Human +DTXSID5023243 Css NA 0.2682 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023243 Css NA 2.152 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023243 Css NA 0.159 mg/L PBTK NA 50% Rat Human +DTXSID5023243 Css NA 1.227 mg/L PBTK NA 95% Rat Human +DTXSID5023247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023247 Fup 0.0657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023247 Vd NA 1.269 L/kg 1compartment NA NA Human Human +DTXSID5023247 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5023247 TK.Half.Life NA 4.668 hours 1compartment NA NA Human Human +DTXSID5023247 Css NA 0.4293 mg/L 3compartmentss NA 50% Human Human +DTXSID5023247 Css NA 3.1 mg/L 3compartmentss NA 95% Human Human +DTXSID5023247 Css NA 0.2766 mg/L PBTK NA 50% Human Human +DTXSID5023247 Css NA 1.915 mg/L PBTK NA 95% Human Human +DTXSID5023247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023247 Fup 0.0657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023247 Vd NA 0.9655 L/kg 1compartment NA NA Rat Human DTXSID5023247 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023247 TK.Half.Life NA 7.489 hours 1compartment NA NA Rat Human -DTXSID5023247 Css NA 1.054 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023247 Css NA 4.173 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023247 Css NA 0.6686 mg/L PBTK NA 50% Rat Human -DTXSID5023247 Css NA 2.373 mg/L PBTK NA 95% Rat Human -DTXSID5023293 Clint NA 110.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023293 Fup NA 0.4373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023293 Vd NA 1.768 L/kg 1compartment NA NA Human Human +DTXSID5023247 TK.Half.Life NA 1.914 hours 1compartment NA NA Rat Human +DTXSID5023247 Css NA 0.05632 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023247 Css NA 0.3086 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023247 Css NA 0.0354 mg/L PBTK NA 50% Rat Human +DTXSID5023247 Css NA 0.1856 mg/L PBTK NA 95% Rat Human +DTXSID5023293 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023293 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023293 Vd NA 1.377 L/kg 1compartment NA NA Human Human DTXSID5023293 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023293 TK.Half.Life NA 1.336 hours 1compartment NA NA Human Human -DTXSID5023293 Css NA 0.0114 mg/L 3compartmentss NA 50% Human Human -DTXSID5023293 Css NA 0.08952 mg/L 3compartmentss NA 95% Human Human -DTXSID5023293 Css NA 0.009238 mg/L PBTK NA 50% Human Human -DTXSID5023293 Css NA 0.06558 mg/L PBTK NA 95% Human Human -DTXSID5023293 Clint NA 110.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023293 Fup NA 0.4373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023293 Vd NA 1.45 L/kg 1compartment NA NA Rat Human +DTXSID5023293 TK.Half.Life NA 4.163 hours 1compartment NA NA Human Human +DTXSID5023293 Css NA 0.2734 mg/L 3compartmentss NA 50% Human Human +DTXSID5023293 Css NA 1.577 mg/L 3compartmentss NA 95% Human Human +DTXSID5023293 Css NA 0.2047 mg/L PBTK NA 50% Human Human +DTXSID5023293 Css NA 1.075 mg/L PBTK NA 95% Human Human +DTXSID5023293 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023293 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023293 Vd NA 1.125 L/kg 1compartment NA NA Rat Human DTXSID5023293 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023293 TK.Half.Life NA 0.4851 hours 1compartment NA NA Rat Human -DTXSID5023293 Css NA 0.006143 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023293 Css NA 0.04071 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023293 Css NA 0.004883 mg/L PBTK NA 50% Rat Human -DTXSID5023293 Css NA 0.02848 mg/L PBTK NA 95% Rat Human -DTXSID5023295 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5023293 TK.Half.Life NA 1.759 hours 1compartment NA NA Rat Human +DTXSID5023293 Css NA 0.03254 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023293 Css NA 0.1397 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023293 Css NA 0.02422 mg/L PBTK NA 50% Rat Human +DTXSID5023293 Css NA 0.09216 mg/L PBTK NA 95% Rat Human +DTXSID5023295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5023295 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5023295 Vd NA 0.6031 L/kg 1compartment NA NA Human Human +DTXSID5023295 Vd NA 0.5857 L/kg 1compartment NA NA Human Human DTXSID5023295 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023295 TK.Half.Life NA 4.59 hours 1compartment NA NA Human Human -DTXSID5023295 Css NA 1.007 mg/L 3compartmentss NA 50% Human Human -DTXSID5023295 Css NA 5.798 mg/L 3compartmentss NA 95% Human Human -DTXSID5023295 Css NA 0.7902 mg/L PBTK NA 50% Human Human -DTXSID5023295 Css NA 3.691 mg/L PBTK NA 95% Human Human -DTXSID5023295 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5023295 TK.Half.Life NA 4.458 hours 1compartment NA NA Human Human +DTXSID5023295 Css NA 0.5601 mg/L 3compartmentss NA 50% Human Human +DTXSID5023295 Css NA 3.269 mg/L 3compartmentss NA 95% Human Human +DTXSID5023295 Css NA 0.4355 mg/L PBTK NA 50% Human Human +DTXSID5023295 Css NA 2.087 mg/L PBTK NA 95% Human Human +DTXSID5023295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5023295 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5023295 Vd NA 0.6362 L/kg 1compartment NA NA Rat Human +DTXSID5023295 Vd NA 0.6215 L/kg 1compartment NA NA Rat Human DTXSID5023295 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023295 TK.Half.Life NA 1.65 hours 1compartment NA NA Rat Human -DTXSID5023295 Css NA 0.2592 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023295 Css NA 1.487 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023295 Css NA 0.1958 mg/L PBTK NA 50% Rat Human -DTXSID5023295 Css NA 0.8749 mg/L PBTK NA 95% Rat Human +DTXSID5023295 TK.Half.Life NA 1.612 hours 1compartment NA NA Rat Human +DTXSID5023295 Css NA 0.002851 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023295 Css NA 0.01787 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023295 Css NA 0.002157 mg/L PBTK NA 50% Rat Human +DTXSID5023295 Css NA 0.01101 mg/L PBTK NA 95% Rat Human DTXSID5023299 Clint 2.51 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID5023299 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5023299 Vd NA 1.699 L/kg 1compartment NA NA Human Human DTXSID5023299 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5023299 TK.Half.Life NA 3.044 hours 1compartment NA NA Human Human -DTXSID5023299 Css NA 0.1647 mg/L 3compartmentss NA 50% Human Human -DTXSID5023299 Css NA 1.268 mg/L 3compartmentss NA 95% Human Human -DTXSID5023299 Css NA 0.1585 mg/L PBTK NA 50% Human Human -DTXSID5023299 Css NA 0.911 mg/L PBTK NA 95% Human Human +DTXSID5023299 Css NA 0.1596 mg/L 3compartmentss NA 50% Human Human +DTXSID5023299 Css NA 1.255 mg/L 3compartmentss NA 95% Human Human +DTXSID5023299 Css NA 0.1541 mg/L PBTK NA 50% Human Human +DTXSID5023299 Css NA 0.921 mg/L PBTK NA 95% Human Human DTXSID5023299 Clint 2.51 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID5023299 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5023299 Vd NA 1.69 L/kg 1compartment NA NA Rat Human DTXSID5023299 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5023299 TK.Half.Life NA 1.613 hours 1compartment NA NA Rat Human -DTXSID5023299 Css NA 0.07037 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023299 Css NA 0.4785 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023299 Css NA 0.06835 mg/L PBTK NA 50% Rat Human -DTXSID5023299 Css NA 0.3134 mg/L PBTK NA 95% Rat Human +DTXSID5023299 Css NA 0.01556 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023299 Css NA 0.1074 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023299 Css NA 0.01562 mg/L PBTK NA 50% Rat Human +DTXSID5023299 Css NA 0.07411 mg/L PBTK NA 95% Rat Human DTXSID5023320 Clint 12.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5023320 Fup 0.05 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID5023320 Vd NA 1.573 L/kg 1compartment NA NA Human Human +DTXSID5023320 Vd NA 1.642 L/kg 1compartment NA NA Human Human DTXSID5023320 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023320 TK.Half.Life NA 10.63 hours 1compartment NA NA Human Human -DTXSID5023320 Css NA 0.7368 mg/L 3compartmentss NA 50% Human Human -DTXSID5023320 Css NA 5.649 mg/L 3compartmentss NA 95% Human Human -DTXSID5023320 Css NA 0.484 mg/L PBTK NA 50% Human Human -DTXSID5023320 Css NA 3.51 mg/L PBTK NA 95% Human Human +DTXSID5023320 TK.Half.Life NA 11.19 hours 1compartment NA NA Human Human +DTXSID5023320 Css NA 0.9546 mg/L 3compartmentss NA 50% Human Human +DTXSID5023320 Css NA 7.029 mg/L 3compartmentss NA 95% Human Human +DTXSID5023320 Css NA 0.6394 mg/L PBTK NA 50% Human Human +DTXSID5023320 Css NA 4.709 mg/L PBTK NA 95% Human Human DTXSID5023320 Clint 95.83 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID5023320 Fup 0.07 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID5023320 Vd NA 1.81 L/kg 1compartment NA NA Rat Rat +DTXSID5023320 Vd 2.1 1.843 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID5023320 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID5023320 TK.Half.Life NA 1.448 hours 1compartment NA NA Rat Rat -DTXSID5023320 Css NA 0.05374 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5023320 Css NA 0.3516 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5023320 Css NA 0.03334 mg/L PBTK NA 50% Rat Rat -DTXSID5023320 Css NA 0.2063 mg/L PBTK NA 95% Rat Rat +DTXSID5023320 TK.Half.Life 0.087 1.469 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID5023320 Css 0.0025 0.0112 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID5023320 Css 0.0025 0.06956 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID5023320 Css 0.0025 0.007774 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID5023320 Css 0.0025 0.04826 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID5023322 Clint 33.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5023322 Fup 0.0167 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5023322 Vd NA 2.905 L/kg 1compartment NA NA Human Human +DTXSID5023322 Vd NA 2.938 L/kg 1compartment NA NA Human Human DTXSID5023322 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5023322 TK.Half.Life NA 36.48 hours 1compartment NA NA Human Human -DTXSID5023322 Css NA 1.476 mg/L 3compartmentss NA 50% Human Human -DTXSID5023322 Css NA 8.976 mg/L 3compartmentss NA 95% Human Human -DTXSID5023322 Css NA 1.012 mg/L PBTK NA 50% Human Human -DTXSID5023322 Css NA 5.985 mg/L PBTK NA 95% Human Human +DTXSID5023322 TK.Half.Life NA 38.36 hours 1compartment NA NA Human Human +DTXSID5023322 Css NA 1.493 mg/L 3compartmentss NA 50% Human Human +DTXSID5023322 Css NA 9.407 mg/L 3compartmentss NA 95% Human Human +DTXSID5023322 Css NA 1.028 mg/L PBTK NA 50% Human Human +DTXSID5023322 Css NA 6.274 mg/L PBTK NA 95% Human Human DTXSID5023322 Clint 33.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5023322 Fup 0.0167 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5023322 Vd NA 2.174 L/kg 1compartment NA NA Rat Human +DTXSID5023322 Vd NA 2.198 L/kg 1compartment NA NA Rat Human DTXSID5023322 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5023322 TK.Half.Life NA 6.57 hours 1compartment NA NA Rat Human -DTXSID5023322 Css NA 0.824 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023322 Css NA 4.347 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023322 Css NA 0.5404 mg/L PBTK NA 50% Rat Human -DTXSID5023322 Css NA 2.85 mg/L PBTK NA 95% Rat Human -DTXSID5023324 Clint NA 0.5266 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5023322 TK.Half.Life NA 6.678 hours 1compartment NA NA Rat Human +DTXSID5023322 Css NA 0.1939 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023322 Css NA 1.096 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023322 Css NA 0.1314 mg/L PBTK NA 50% Rat Human +DTXSID5023322 Css NA 0.7426 mg/L PBTK NA 95% Rat Human +DTXSID5023324 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5023324 Fup 0.035 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5023324 Vd NA 0.273 L/kg 1compartment NA NA Human Human -DTXSID5023324 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5023324 TK.Half.Life NA 26.81 hours 1compartment NA NA Human Human -DTXSID5023324 Css NA 17.42 mg/L 3compartmentss NA 50% Human Human -DTXSID5023324 Css NA 82.15 mg/L 3compartmentss NA 95% Human Human -DTXSID5023324 Css NA 10.32 mg/L PBTK NA 50% Human Human -DTXSID5023324 Css NA 48.25 mg/L PBTK NA 95% Human Human -DTXSID5023324 Clint NA 0.5266 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5023324 Vd NA 0.2217 L/kg 1compartment NA NA Human Human +DTXSID5023324 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5023324 TK.Half.Life NA 3.773 hours 1compartment NA NA Human Human +DTXSID5023324 Css NA 3.075 mg/L 3compartmentss NA 50% Human Human +DTXSID5023324 Css NA 19.95 mg/L 3compartmentss NA 95% Human Human +DTXSID5023324 Css NA 1.812 mg/L PBTK NA 50% Human Human +DTXSID5023324 Css NA 11.63 mg/L PBTK NA 95% Human Human +DTXSID5023324 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5023324 Fup 0.035 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5023324 Vd NA 0.2474 L/kg 1compartment NA NA Rat Human -DTXSID5023324 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5023324 TK.Half.Life NA 10.89 hours 1compartment NA NA Rat Human -DTXSID5023324 Css NA 6.576 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023324 Css NA 25.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023324 Css NA 3.641 mg/L PBTK NA 50% Rat Human -DTXSID5023324 Css NA 13.81 mg/L PBTK NA 95% Rat Human -DTXSID5023370 Clint NA 248.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5023324 Vd NA 0.2162 L/kg 1compartment NA NA Rat Human +DTXSID5023324 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5023324 TK.Half.Life NA 2.316 hours 1compartment NA NA Rat Human +DTXSID5023324 Css NA 0.3792 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023324 Css NA 1.798 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023324 Css NA 0.2168 mg/L PBTK NA 50% Rat Human +DTXSID5023324 Css NA 1.013 mg/L PBTK NA 95% Rat Human +DTXSID5023370 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5023370 Fup 0.016 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5023370 Vd NA 0.8581 L/kg 1compartment NA NA Human Human +DTXSID5023370 Vd NA 0.8582 L/kg 1compartment NA NA Human Human DTXSID5023370 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023370 TK.Half.Life NA 1.544 hours 1compartment NA NA Human Human -DTXSID5023370 Css NA 0.162 mg/L 3compartmentss NA 50% Human Human -DTXSID5023370 Css NA 1.605 mg/L 3compartmentss NA 95% Human Human -DTXSID5023370 Css NA 0.09846 mg/L PBTK NA 50% Human Human -DTXSID5023370 Css NA 0.946 mg/L PBTK NA 95% Human Human -DTXSID5023370 Clint NA 248.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5023370 TK.Half.Life NA 9.064 hours 1compartment NA NA Human Human +DTXSID5023370 Css NA 1.727 mg/L 3compartmentss NA 50% Human Human +DTXSID5023370 Css NA 17.11 mg/L 3compartmentss NA 95% Human Human +DTXSID5023370 Css NA 1.049 mg/L PBTK NA 50% Human Human +DTXSID5023370 Css NA 10.12 mg/L PBTK NA 95% Human Human +DTXSID5023370 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5023370 Fup 0.016 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5023370 Vd NA 0.6455 L/kg 1compartment NA NA Rat Human DTXSID5023370 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023370 TK.Half.Life NA 0.6205 hours 1compartment NA NA Rat Human -DTXSID5023370 Css NA 0.09356 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023370 Css NA 0.7738 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023370 Css NA 0.05264 mg/L PBTK NA 50% Rat Human -DTXSID5023370 Css NA 0.4289 mg/L PBTK NA 95% Rat Human -DTXSID5023372 Clint NA 4.745 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5023370 TK.Half.Life NA 4.163 hours 1compartment NA NA Rat Human +DTXSID5023370 Css NA 0.2288 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023370 Css NA 1.766 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023370 Css NA 0.1336 mg/L PBTK NA 50% Rat Human +DTXSID5023370 Css NA 1.007 mg/L PBTK NA 95% Rat Human +DTXSID5023372 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5023372 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5023372 Vd NA 1.032 L/kg 1compartment NA NA Human Human DTXSID5023372 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023372 TK.Half.Life NA 6.583 hours 1compartment NA NA Human Human -DTXSID5023372 Css NA 0.6586 mg/L 3compartmentss NA 50% Human Human -DTXSID5023372 Css NA 4.946 mg/L 3compartmentss NA 95% Human Human -DTXSID5023372 Css NA 0.5952 mg/L PBTK NA 50% Human Human -DTXSID5023372 Css NA 3.686 mg/L PBTK NA 95% Human Human -DTXSID5023372 Clint NA 4.745 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5023372 TK.Half.Life NA 5.247 hours 1compartment NA NA Human Human +DTXSID5023372 Css NA 0.4533 mg/L 3compartmentss NA 50% Human Human +DTXSID5023372 Css NA 2.919 mg/L 3compartmentss NA 95% Human Human +DTXSID5023372 Css NA 0.4528 mg/L PBTK NA 50% Human Human +DTXSID5023372 Css NA 2.918 mg/L PBTK NA 95% Human Human +DTXSID5023372 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5023372 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5023372 Vd NA 0.822 L/kg 1compartment NA NA Rat Human DTXSID5023372 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023372 TK.Half.Life NA 2.919 hours 1compartment NA NA Rat Human -DTXSID5023372 Css NA 0.3277 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023372 Css NA 1.876 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023372 Css NA 0.2892 mg/L PBTK NA 50% Rat Human -DTXSID5023372 Css NA 1.258 mg/L PBTK NA 95% Rat Human -DTXSID5023376 Clint NA 46.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5023372 TK.Half.Life NA 2.363 hours 1compartment NA NA Rat Human +DTXSID5023372 Css NA 0.05226 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023372 Css NA 0.2475 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023372 Css NA 0.05412 mg/L PBTK NA 50% Rat Human +DTXSID5023372 Css NA 0.2562 mg/L PBTK NA 95% Rat Human +DTXSID5023376 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5023376 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5023376 Vd NA 19 L/kg 1compartment NA NA Human Human -DTXSID5023376 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023376 TK.Half.Life NA 13.6 hours 1compartment NA NA Human Human -DTXSID5023376 Css NA 0.01549 mg/L 3compartmentss NA 50% Human Human -DTXSID5023376 Css NA 0.1762 mg/L 3compartmentss NA 95% Human Human -DTXSID5023376 Css NA 0.01288 mg/L PBTK NA 50% Human Human -DTXSID5023376 Css NA 0.1191 mg/L PBTK NA 95% Human Human -DTXSID5023376 Clint NA 46.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5023376 Vd NA 18.67 L/kg 1compartment NA NA Human Human +DTXSID5023376 Days.Css NA 33 Days PBTK NA NA Human Human +DTXSID5023376 TK.Half.Life NA 191.5 hours 1compartment NA NA Human Human +DTXSID5023376 Css NA 0.5883 mg/L 3compartmentss NA 50% Human Human +DTXSID5023376 Css NA 3.122 mg/L 3compartmentss NA 95% Human Human +DTXSID5023376 Css NA 0.5118 mg/L PBTK NA 50% Human Human +DTXSID5023376 Css NA 2.716 mg/L PBTK NA 95% Human Human +DTXSID5023376 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5023376 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5023376 Vd NA 25.19 L/kg 1compartment NA NA Rat Human -DTXSID5023376 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023376 TK.Half.Life NA 7.631 hours 1compartment NA NA Rat Human -DTXSID5023376 Css NA 0.006807 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023376 Css NA 0.06192 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023376 Css NA 0.005391 mg/L PBTK NA 50% Rat Human -DTXSID5023376 Css NA 0.04189 mg/L PBTK NA 95% Rat Human -DTXSID5023378 Clint NA 1.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023378 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023378 Vd NA 1.733 L/kg 1compartment NA NA Human Human -DTXSID5023378 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023378 TK.Half.Life NA 4.116 hours 1compartment NA NA Human Human -DTXSID5023378 Css NA 0.2429 mg/L 3compartmentss NA 50% Human Human -DTXSID5023378 Css NA 1.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5023378 Css NA 0.2388 mg/L PBTK NA 50% Human Human -DTXSID5023378 Css NA 1.285 mg/L PBTK NA 95% Human Human -DTXSID5023378 Clint NA 1.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023378 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023378 Vd NA 1.776 L/kg 1compartment NA NA Rat Human +DTXSID5023376 Vd NA 24.56 L/kg 1compartment NA NA Rat Human +DTXSID5023376 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID5023376 TK.Half.Life NA 63.59 hours 1compartment NA NA Rat Human +DTXSID5023376 Css NA 0.002493 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023376 Css NA 0.01292 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023376 Css NA 0.002174 mg/L PBTK NA 50% Rat Human +DTXSID5023376 Css NA 0.01127 mg/L PBTK NA 95% Rat Human +DTXSID5023378 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023378 Fup 0.777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023378 Vd NA 1.472 L/kg 1compartment NA NA Human Human +DTXSID5023378 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5023378 TK.Half.Life NA 12.26 hours 1compartment NA NA Human Human +DTXSID5023378 Css NA 0.7658 mg/L 3compartmentss NA 50% Human Human +DTXSID5023378 Css NA 5.004 mg/L 3compartmentss NA 95% Human Human +DTXSID5023378 Css NA 0.7176 mg/L PBTK NA 50% Human Human +DTXSID5023378 Css NA 3.354 mg/L PBTK NA 95% Human Human +DTXSID5023378 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023378 Fup 0.777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023378 Vd NA 1.506 L/kg 1compartment NA NA Rat Human DTXSID5023378 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023378 TK.Half.Life NA 2.082 hours 1compartment NA NA Rat Human -DTXSID5023378 Css NA 0.09174 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023378 Css NA 0.648 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023378 Css NA 0.0904 mg/L PBTK NA 50% Rat Human -DTXSID5023378 Css NA 0.4155 mg/L PBTK NA 95% Rat Human -DTXSID5023453 Clint NA 0.4121 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023453 Fup NA 0.0192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023453 Vd NA 0.2089 L/kg 1compartment NA NA Human Human -DTXSID5023453 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID5023453 TK.Half.Life NA 41.83 hours 1compartment NA NA Human Human -DTXSID5023453 Css NA 33.79 mg/L 3compartmentss NA 50% Human Human -DTXSID5023453 Css NA 218.3 mg/L 3compartmentss NA 95% Human Human -DTXSID5023453 Css NA 20.03 mg/L PBTK NA 50% Human Human -DTXSID5023453 Css NA 129 mg/L PBTK NA 95% Human Human -DTXSID5023453 Clint NA 0.4121 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023453 Fup NA 0.0192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023453 Vd NA 0.203 L/kg 1compartment NA NA Rat Human -DTXSID5023453 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5023453 TK.Half.Life NA 17.5 hours 1compartment NA NA Rat Human -DTXSID5023453 Css NA 12.32 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023453 Css NA 71.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023453 Css NA 6.796 mg/L PBTK NA 50% Rat Human -DTXSID5023453 Css NA 38.7 mg/L PBTK NA 95% Rat Human -DTXSID5023532 Clint NA 104.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023532 Fup NA 0.0901 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023532 Vd NA 0.5161 L/kg 1compartment NA NA Human Human -DTXSID5023532 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023532 TK.Half.Life NA 0.6691 hours 1compartment NA NA Human Human -DTXSID5023532 Css NA 0.07107 mg/L 3compartmentss NA 50% Human Human -DTXSID5023532 Css NA 0.5953 mg/L 3compartmentss NA 95% Human Human -DTXSID5023532 Css NA 0.04385 mg/L PBTK NA 50% Human Human -DTXSID5023532 Css NA 0.3611 mg/L PBTK NA 95% Human Human -DTXSID5023532 Clint NA 104.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023532 Fup NA 0.0901 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023532 Vd NA 0.4298 L/kg 1compartment NA NA Rat Human -DTXSID5023532 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023532 TK.Half.Life NA 0.2845 hours 1compartment NA NA Rat Human -DTXSID5023532 Css NA 0.04023 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023532 Css NA 0.2807 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023532 Css NA 0.0235 mg/L PBTK NA 50% Rat Human -DTXSID5023532 Css NA 0.1585 mg/L PBTK NA 95% Rat Human -DTXSID5023536 Clint NA 3.116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023536 Fup NA 0.59 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023536 Vd NA 0.5952 L/kg 1compartment NA NA Human Human +DTXSID5023378 TK.Half.Life NA 4.273 hours 1compartment NA NA Rat Human +DTXSID5023378 Css NA 0.01884 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023378 Css NA 0.1487 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023378 Css NA 0.01724 mg/L PBTK NA 50% Rat Human +DTXSID5023378 Css NA 0.1034 mg/L PBTK NA 95% Rat Human +DTXSID5023407 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023407 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5023407 Vd NA 1.793 L/kg 1compartment NA NA Human Human +DTXSID5023407 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5023407 TK.Half.Life NA 21.78 hours 1compartment NA NA Human Human +DTXSID5023407 Css NA 1.011 mg/L 3compartmentss NA 50% Human Human +DTXSID5023407 Css NA 4.977 mg/L 3compartmentss NA 95% Human Human +DTXSID5023407 Css NA 1.042 mg/L PBTK NA 50% Human Human +DTXSID5023407 Css NA 5.126 mg/L PBTK NA 95% Human Human +DTXSID5023407 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023407 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5023407 Vd NA 1.771 L/kg 1compartment NA NA Rat Human +DTXSID5023407 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5023407 TK.Half.Life NA 7.154 hours 1compartment NA NA Rat Human +DTXSID5023407 Css NA 0.06039 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023407 Css NA 0.2636 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023407 Css NA 0.06438 mg/L PBTK NA 50% Rat Human +DTXSID5023407 Css NA 0.2812 mg/L PBTK NA 95% Rat Human +DTXSID5023453 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023453 Fup 0.0363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023453 Vd NA 1.119 L/kg 1compartment NA NA Human Human +DTXSID5023453 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5023453 TK.Half.Life NA 6.284 hours 1compartment NA NA Human Human +DTXSID5023453 Css NA 0.8458 mg/L 3compartmentss NA 50% Human Human +DTXSID5023453 Css NA 6.641 mg/L 3compartmentss NA 95% Human Human +DTXSID5023453 Css NA 0.5234 mg/L PBTK NA 50% Human Human +DTXSID5023453 Css NA 4.013 mg/L PBTK NA 95% Human Human +DTXSID5023453 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023453 Fup 0.0363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023453 Vd NA 0.8424 L/kg 1compartment NA NA Rat Human +DTXSID5023453 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5023453 TK.Half.Life NA 2.681 hours 1compartment NA NA Rat Human +DTXSID5023453 Css NA 0.1118 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023453 Css NA 0.6844 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023453 Css NA 0.06712 mg/L PBTK NA 50% Rat Human +DTXSID5023453 Css NA 0.3957 mg/L PBTK NA 95% Rat Human +DTXSID5023459 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023459 Fup 0.57 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5023459 Vd NA 3.09 L/kg 1compartment NA NA Human Human +DTXSID5023459 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5023459 TK.Half.Life NA 13.04 hours 1compartment NA NA Human Human +DTXSID5023459 Css NA 0.4018 mg/L 3compartmentss NA 50% Human Human +DTXSID5023459 Css NA 2.659 mg/L 3compartmentss NA 95% Human Human +DTXSID5023459 Css NA 0.2919 mg/L PBTK NA 50% Human Human +DTXSID5023459 Css NA 1.862 mg/L PBTK NA 95% Human Human +DTXSID5023459 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023459 Fup 0.57 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5023459 Vd NA 2.34 L/kg 1compartment NA NA Rat Human +DTXSID5023459 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5023459 TK.Half.Life NA 2.3 hours 1compartment NA NA Rat Human +DTXSID5023459 Css NA 0.05181 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023459 Css NA 0.2571 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023459 Css NA 0.03755 mg/L PBTK NA 50% Rat Human +DTXSID5023459 Css NA 0.1806 mg/L PBTK NA 95% Rat Human +DTXSID5023532 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023532 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023532 Vd NA 0.5854 L/kg 1compartment NA NA Human Human +DTXSID5023532 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5023532 TK.Half.Life NA 33.96 hours 1compartment NA NA Human Human +DTXSID5023532 Css NA 7.382 mg/L 3compartmentss NA 50% Human Human +DTXSID5023532 Css NA 34.55 mg/L 3compartmentss NA 95% Human Human +DTXSID5023532 Css NA 4.719 mg/L PBTK NA 50% Human Human +DTXSID5023532 Css NA 20.75 mg/L PBTK NA 95% Human Human +DTXSID5023532 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023532 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023532 Vd NA 0.4868 L/kg 1compartment NA NA Rat Human +DTXSID5023532 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5023532 TK.Half.Life NA 9.342 hours 1compartment NA NA Rat Human +DTXSID5023532 Css NA 0.179 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023532 Css NA 1.14 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023532 Css NA 0.1107 mg/L PBTK NA 50% Rat Human +DTXSID5023532 Css NA 0.6627 mg/L PBTK NA 95% Rat Human +DTXSID5023536 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023536 Fup 0.818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023536 Vd NA 0.7205 L/kg 1compartment NA NA Human Human DTXSID5023536 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023536 TK.Half.Life NA 1.344 hours 1compartment NA NA Human Human -DTXSID5023536 Css NA 0.2198 mg/L 3compartmentss NA 50% Human Human -DTXSID5023536 Css NA 1.802 mg/L 3compartmentss NA 95% Human Human -DTXSID5023536 Css NA 0.1693 mg/L PBTK NA 50% Human Human -DTXSID5023536 Css NA 1.144 mg/L PBTK NA 95% Human Human -DTXSID5023536 Clint NA 3.116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023536 Fup NA 0.59 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023536 Vd NA 0.6174 L/kg 1compartment NA NA Rat Human +DTXSID5023536 TK.Half.Life NA 5.705 hours 1compartment NA NA Human Human +DTXSID5023536 Css NA 0.953 mg/L 3compartmentss NA 50% Human Human +DTXSID5023536 Css NA 5.661 mg/L 3compartmentss NA 95% Human Human +DTXSID5023536 Css NA 0.7837 mg/L PBTK NA 50% Human Human +DTXSID5023536 Css NA 3.662 mg/L PBTK NA 95% Human Human +DTXSID5023536 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023536 Fup 0.818 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023536 Vd NA 0.7491 L/kg 1compartment NA NA Rat Human DTXSID5023536 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023536 TK.Half.Life NA 0.7521 hours 1compartment NA NA Rat Human -DTXSID5023536 Css NA 0.1011 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023536 Css NA 0.7117 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023536 Css NA 0.07493 mg/L PBTK NA 50% Rat Human -DTXSID5023536 Css NA 0.4143 mg/L PBTK NA 95% Rat Human +DTXSID5023536 TK.Half.Life NA 2.02 hours 1compartment NA NA Rat Human +DTXSID5023536 Css NA 0.05628 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023536 Css NA 0.3421 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023536 Css NA 0.04645 mg/L PBTK NA 50% Rat Human +DTXSID5023536 Css NA 0.2103 mg/L PBTK NA 95% Rat Human DTXSID5023582 Clint 50.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID5023582 Fup NA 0.0407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023582 Vd NA 1.415 L/kg 1compartment NA NA Human Human -DTXSID5023582 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023582 TK.Half.Life NA 4.035 hours 1compartment NA NA Human Human -DTXSID5023582 Css NA 0.3475 mg/L 3compartmentss NA 50% Human Human -DTXSID5023582 Css NA 3.221 mg/L 3compartmentss NA 95% Human Human -DTXSID5023582 Css NA 0.2204 mg/L PBTK NA 50% Human Human -DTXSID5023582 Css NA 1.933 mg/L PBTK NA 95% Human Human +DTXSID5023582 Fup 0.0981 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023582 Vd NA 3.112 L/kg 1compartment NA NA Human Human +DTXSID5023582 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5023582 TK.Half.Life NA 26.38 hours 1compartment NA NA Human Human +DTXSID5023582 Css NA 0.9235 mg/L 3compartmentss NA 50% Human Human +DTXSID5023582 Css NA 5.765 mg/L 3compartmentss NA 95% Human Human +DTXSID5023582 Css NA 0.6438 mg/L PBTK NA 50% Human Human +DTXSID5023582 Css NA 3.903 mg/L PBTK NA 95% Human Human DTXSID5023582 Clint 50.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID5023582 Fup NA 0.0407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023582 Vd NA 1.063 L/kg 1compartment NA NA Rat Human -DTXSID5023582 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023582 TK.Half.Life NA 1.566 hours 1compartment NA NA Rat Human -DTXSID5023582 Css NA 0.1979 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023582 Css NA 1.403 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023582 Css NA 0.1178 mg/L PBTK NA 50% Rat Human -DTXSID5023582 Css NA 0.7957 mg/L PBTK NA 95% Rat Human -DTXSID5023584 Clint NA 96.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023584 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023584 Vd NA 384.4 L/kg 1compartment NA NA Human Human -DTXSID5023584 Days.Css NA 25 Days PBTK NA NA Human Human -DTXSID5023584 TK.Half.Life NA 155.2 hours 1compartment NA NA Human Human -DTXSID5023584 Css NA 0.0008646 mg/L 3compartmentss NA 50% Human Human -DTXSID5023584 Css NA 0.01495 mg/L 3compartmentss NA 95% Human Human -DTXSID5023584 Css NA 0.04104 mg/L PBTK NA 50% Human Human -DTXSID5023584 Css NA 0.3252 mg/L PBTK NA 95% Human Human -DTXSID5023584 Clint NA 96.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023584 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023584 Vd NA 344.7 L/kg 1compartment NA NA Rat Human -DTXSID5023584 Days.Css NA 20 Days PBTK NA NA Rat Human -DTXSID5023584 TK.Half.Life NA 54.24 hours 1compartment NA NA Rat Human -DTXSID5023584 Css NA 0.000431 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023584 Css NA 0.006508 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023584 Css NA 0.02218 mg/L PBTK NA 50% Rat Human -DTXSID5023584 Css NA 0.1479 mg/L PBTK NA 95% Rat Human -DTXSID5023586 Clint NA 462.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023586 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023586 Vd NA 3.749 L/kg 1compartment NA NA Human Human -DTXSID5023586 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023586 TK.Half.Life NA 6.054 hours 1compartment NA NA Human Human -DTXSID5023586 Css NA 0.1205 mg/L 3compartmentss NA 50% Human Human -DTXSID5023586 Css NA 0.9832 mg/L 3compartmentss NA 95% Human Human -DTXSID5023586 Css NA 0.08799 mg/L PBTK NA 50% Human Human -DTXSID5023586 Css NA 0.6632 mg/L PBTK NA 95% Human Human -DTXSID5023586 Clint NA 462.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023586 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023586 Vd NA 2.835 L/kg 1compartment NA NA Rat Human -DTXSID5023586 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023586 TK.Half.Life NA 1.821 hours 1compartment NA NA Rat Human -DTXSID5023586 Css NA 0.06818 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023586 Css NA 0.4654 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023586 Css NA 0.04722 mg/L PBTK NA 50% Rat Human -DTXSID5023586 Css NA 0.3001 mg/L PBTK NA 95% Rat Human +DTXSID5023582 Fup 0.0981 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023582 Vd NA 2.333 L/kg 1compartment NA NA Rat Human +DTXSID5023582 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5023582 TK.Half.Life NA 3.972 hours 1compartment NA NA Rat Human +DTXSID5023582 Css NA 0.1137 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023582 Css NA 0.6596 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023582 Css NA 0.07883 mg/L PBTK NA 50% Rat Human +DTXSID5023582 Css NA 0.4526 mg/L PBTK NA 95% Rat Human +DTXSID5023584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023584 Fup 0.037 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023584 Vd NA 53 L/kg 1compartment NA NA Human Human +DTXSID5023584 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID5023584 TK.Half.Life NA 64.84 hours 1compartment NA NA Human Human +DTXSID5023584 Css NA 0.008874 mg/L 3compartmentss NA 50% Human Human +DTXSID5023584 Css NA 0.08807 mg/L 3compartmentss NA 95% Human Human +DTXSID5023584 Css NA 0.051 mg/L PBTK NA 50% Human Human +DTXSID5023584 Css NA 0.3667 mg/L PBTK NA 95% Human Human +DTXSID5023584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023584 Fup 0.037 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023584 Vd NA 44.87 L/kg 1compartment NA NA Rat Human +DTXSID5023584 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID5023584 TK.Half.Life NA 12.83 hours 1compartment NA NA Rat Human +DTXSID5023584 Css NA 7.896e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023584 Css NA 0.0008067 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023584 Css NA 0.0004765 mg/L PBTK NA 50% Rat Human +DTXSID5023584 Css NA 0.003676 mg/L PBTK NA 95% Rat Human +DTXSID5023586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023586 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023586 Vd NA 4.452 L/kg 1compartment NA NA Human Human +DTXSID5023586 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID5023586 TK.Half.Life NA 68.36 hours 1compartment NA NA Human Human +DTXSID5023586 Css NA 1.819 mg/L 3compartmentss NA 50% Human Human +DTXSID5023586 Css NA 13.74 mg/L 3compartmentss NA 95% Human Human +DTXSID5023586 Css NA 1.403 mg/L PBTK NA 50% Human Human +DTXSID5023586 Css NA 9.846 mg/L PBTK NA 95% Human Human +DTXSID5023586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023586 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023586 Vd NA 3.389 L/kg 1compartment NA NA Rat Human +DTXSID5023586 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID5023586 TK.Half.Life NA 15.02 hours 1compartment NA NA Rat Human +DTXSID5023586 Css NA 0.2318 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023586 Css NA 1.442 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023586 Css NA 0.178 mg/L PBTK NA 50% Rat Human +DTXSID5023586 Css NA 1.041 mg/L PBTK NA 95% Rat Human DTXSID5023588 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5023588 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5023588 Vd NA 0.6753 L/kg 1compartment NA NA Human Human DTXSID5023588 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5023588 TK.Half.Life NA 4.37 hours 1compartment NA NA Human Human -DTXSID5023588 Css NA 0.8569 mg/L 3compartmentss NA 50% Human Human -DTXSID5023588 Css NA 5.588 mg/L 3compartmentss NA 95% Human Human -DTXSID5023588 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID5023588 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID5023588 Css NA 0.7226 mg/L 3compartmentss NA 50% Human Human +DTXSID5023588 Css NA 5.093 mg/L 3compartmentss NA 95% Human Human +DTXSID5023588 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID5023588 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID5023588 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5023588 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5023588 Vd NA 0.7232 L/kg 1compartment NA NA Rat Human DTXSID5023588 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5023588 TK.Half.Life NA 1.595 hours 1compartment NA NA Rat Human -DTXSID5023588 Css NA 0.2156 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023588 Css NA 1.344 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023588 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID5023588 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5023611 Clint NA 6.623 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023611 Fup NA 0.1207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023611 Vd NA 0.2436 L/kg 1compartment NA NA Human Human +DTXSID5023588 Css NA 0.01328 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023588 Css NA 0.1009 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023588 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID5023588 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID5023611 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023611 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023611 Vd NA 0.2901 L/kg 1compartment NA NA Human Human DTXSID5023611 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023611 TK.Half.Life NA 1.281 hours 1compartment NA NA Human Human -DTXSID5023611 Css NA 0.7556 mg/L 3compartmentss NA 50% Human Human -DTXSID5023611 Css NA 5.191 mg/L 3compartmentss NA 95% Human Human -DTXSID5023611 Css NA 0.4593 mg/L PBTK NA 50% Human Human -DTXSID5023611 Css NA 3.062 mg/L PBTK NA 95% Human Human -DTXSID5023611 Clint NA 6.623 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023611 Fup NA 0.1207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023611 Vd NA 0.2439 L/kg 1compartment NA NA Rat Human +DTXSID5023611 TK.Half.Life NA 1.036 hours 1compartment NA NA Human Human +DTXSID5023611 Css NA 0.3764 mg/L 3compartmentss NA 50% Human Human +DTXSID5023611 Css NA 2.015 mg/L 3compartmentss NA 95% Human Human +DTXSID5023611 Css NA 0.2388 mg/L PBTK NA 50% Human Human +DTXSID5023611 Css NA 1.227 mg/L PBTK NA 95% Human Human +DTXSID5023611 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023611 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023611 Vd NA 0.2918 L/kg 1compartment NA NA Rat Human DTXSID5023611 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023611 TK.Half.Life NA 0.7752 hours 1compartment NA NA Rat Human -DTXSID5023611 Css NA 0.3998 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023611 Css NA 2.035 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023611 Css NA 0.229 mg/L PBTK NA 50% Rat Human -DTXSID5023611 Css NA 1.127 mg/L PBTK NA 95% Rat Human -DTXSID5023613 Clint NA 8.029 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023613 Fup NA 0.1037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023613 Vd NA 0.2958 L/kg 1compartment NA NA Human Human +DTXSID5023611 TK.Half.Life NA 0.6096 hours 1compartment NA NA Rat Human +DTXSID5023611 Css NA 0.04499 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023611 Css NA 0.1824 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023611 Css NA 0.02788 mg/L PBTK NA 50% Rat Human +DTXSID5023611 Css NA 0.1081 mg/L PBTK NA 95% Rat Human +DTXSID5023613 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023613 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023613 Vd NA 0.389 L/kg 1compartment NA NA Human Human DTXSID5023613 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023613 TK.Half.Life NA 1.523 hours 1compartment NA NA Human Human -DTXSID5023613 Css NA 0.7499 mg/L 3compartmentss NA 50% Human Human -DTXSID5023613 Css NA 5.317 mg/L 3compartmentss NA 95% Human Human -DTXSID5023613 Css NA 0.458 mg/L PBTK NA 50% Human Human -DTXSID5023613 Css NA 3.173 mg/L PBTK NA 95% Human Human -DTXSID5023613 Clint NA 8.029 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023613 Fup NA 0.1037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023613 Vd NA 0.2896 L/kg 1compartment NA NA Rat Human +DTXSID5023613 TK.Half.Life NA 1.407 hours 1compartment NA NA Human Human +DTXSID5023613 Css NA 0.367 mg/L 3compartmentss NA 50% Human Human +DTXSID5023613 Css NA 2.236 mg/L 3compartmentss NA 95% Human Human +DTXSID5023613 Css NA 0.239 mg/L PBTK NA 50% Human Human +DTXSID5023613 Css NA 1.381 mg/L PBTK NA 95% Human Human +DTXSID5023613 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023613 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023613 Vd NA 0.3821 L/kg 1compartment NA NA Rat Human DTXSID5023613 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023613 TK.Half.Life NA 0.9108 hours 1compartment NA NA Rat Human -DTXSID5023613 Css NA 0.3977 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023613 Css NA 2.099 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023613 Css NA 0.2288 mg/L PBTK NA 50% Rat Human -DTXSID5023613 Css NA 1.17 mg/L PBTK NA 95% Rat Human -DTXSID5023615 Clint NA 4.112 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023615 Fup NA 0.0943 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023615 Vd NA 0.2218 L/kg 1compartment NA NA Human Human +DTXSID5023613 TK.Half.Life NA 0.8112 hours 1compartment NA NA Rat Human +DTXSID5023613 Css NA 0.04466 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023613 Css NA 0.1889 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023613 Css NA 0.02854 mg/L PBTK NA 50% Rat Human +DTXSID5023613 Css NA 0.114 mg/L PBTK NA 95% Rat Human +DTXSID5023615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023615 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023615 Vd NA 0.2544 L/kg 1compartment NA NA Human Human DTXSID5023615 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023615 TK.Half.Life NA 2.095 hours 1compartment NA NA Human Human -DTXSID5023615 Css NA 1.506 mg/L 3compartmentss NA 50% Human Human -DTXSID5023615 Css NA 9.836 mg/L 3compartmentss NA 95% Human Human -DTXSID5023615 Css NA 0.9056 mg/L PBTK NA 50% Human Human -DTXSID5023615 Css NA 5.713 mg/L PBTK NA 95% Human Human -DTXSID5023615 Clint NA 4.112 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023615 Fup NA 0.0943 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023615 Vd NA 0.2224 L/kg 1compartment NA NA Rat Human +DTXSID5023615 TK.Half.Life NA 1.14 hours 1compartment NA NA Human Human +DTXSID5023615 Css NA 0.451 mg/L 3compartmentss NA 50% Human Human +DTXSID5023615 Css NA 3.102 mg/L 3compartmentss NA 95% Human Human +DTXSID5023615 Css NA 0.2775 mg/L PBTK NA 50% Human Human +DTXSID5023615 Css NA 1.873 mg/L PBTK NA 95% Human Human +DTXSID5023615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023615 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023615 Vd NA 0.2564 L/kg 1compartment NA NA Rat Human DTXSID5023615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023615 TK.Half.Life NA 1.255 hours 1compartment NA NA Rat Human -DTXSID5023615 Css NA 0.7752 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023615 Css NA 3.613 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023615 Css NA 0.4369 mg/L PBTK NA 50% Rat Human -DTXSID5023615 Css NA 1.974 mg/L PBTK NA 95% Rat Human -DTXSID5023661 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023661 Fup NA 0.9068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023661 Vd NA 0.7447 L/kg 1compartment NA NA Human Human +DTXSID5023615 TK.Half.Life NA 0.6849 hours 1compartment NA NA Rat Human +DTXSID5023615 Css NA 0.009494 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023615 Css NA 0.08207 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023615 Css NA 0.005558 mg/L PBTK NA 50% Rat Human +DTXSID5023615 Css NA 0.04708 mg/L PBTK NA 95% Rat Human +DTXSID5023661 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023661 Fup 0.922 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023661 Vd NA 0.7351 L/kg 1compartment NA NA Human Human DTXSID5023661 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023661 TK.Half.Life NA 5.316 hours 1compartment NA NA Human Human -DTXSID5023661 Css NA 0.9238 mg/L 3compartmentss NA 50% Human Human -DTXSID5023661 Css NA 5.332 mg/L 3compartmentss NA 95% Human Human -DTXSID5023661 Css NA 0.761 mg/L PBTK NA 50% Human Human -DTXSID5023661 Css NA 3.452 mg/L PBTK NA 95% Human Human -DTXSID5023661 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023661 Fup NA 0.9068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023661 Vd NA 0.7801 L/kg 1compartment NA NA Rat Human +DTXSID5023661 TK.Half.Life NA 5.161 hours 1compartment NA NA Human Human +DTXSID5023661 Css NA 0.5043 mg/L 3compartmentss NA 50% Human Human +DTXSID5023661 Css NA 2.849 mg/L 3compartmentss NA 95% Human Human +DTXSID5023661 Css NA 0.4156 mg/L PBTK NA 50% Human Human +DTXSID5023661 Css NA 1.86 mg/L PBTK NA 95% Human Human +DTXSID5023661 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023661 Fup 0.922 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023661 Vd NA 0.7678 L/kg 1compartment NA NA Rat Human DTXSID5023661 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023661 TK.Half.Life NA 1.897 hours 1compartment NA NA Rat Human -DTXSID5023661 Css NA 0.238 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023661 Css NA 1.337 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023661 Css NA 0.1904 mg/L PBTK NA 50% Rat Human -DTXSID5023661 Css NA 0.8042 mg/L PBTK NA 95% Rat Human -DTXSID5023665 Clint NA 0.5851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5023661 TK.Half.Life NA 1.837 hours 1compartment NA NA Rat Human +DTXSID5023661 Css NA 0.00258 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023661 Css NA 0.01629 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023661 Css NA 0.00206 mg/L PBTK NA 50% Rat Human +DTXSID5023661 Css NA 0.01019 mg/L PBTK NA 95% Rat Human +DTXSID5023663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023663 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5023663 Vd NA 0.8735 L/kg 1compartment NA NA Human Human +DTXSID5023663 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5023663 TK.Half.Life NA 4.438 hours 1compartment NA NA Human Human +DTXSID5023663 Css NA 0.7516 mg/L 3compartmentss NA 50% Human Human +DTXSID5023663 Css NA 7.182 mg/L 3compartmentss NA 95% Human Human +DTXSID5023663 Css NA 0.4654 mg/L PBTK NA 50% Human Human +DTXSID5023663 Css NA 4.271 mg/L PBTK NA 95% Human Human +DTXSID5023663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023663 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5023663 Vd NA 0.6894 L/kg 1compartment NA NA Rat Human +DTXSID5023663 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5023663 TK.Half.Life NA 2.097 hours 1compartment NA NA Rat Human +DTXSID5023663 Css NA 0.0991 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023663 Css NA 0.7265 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023663 Css NA 0.05935 mg/L PBTK NA 50% Rat Human +DTXSID5023663 Css NA 0.4175 mg/L PBTK NA 95% Rat Human +DTXSID5023665 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5023665 Fup 0.015 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5023665 Vd NA 0.2169 L/kg 1compartment NA NA Human Human -DTXSID5023665 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID5023665 TK.Half.Life NA 47.38 hours 1compartment NA NA Human Human -DTXSID5023665 Css NA 37.4 mg/L 3compartmentss NA 50% Human Human -DTXSID5023665 Css NA 242.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5023665 Css NA 22.02 mg/L PBTK NA 50% Human Human -DTXSID5023665 Css NA 143.4 mg/L PBTK NA 95% Human Human -DTXSID5023665 Clint NA 0.5851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5023665 Vd NA 0.192 L/kg 1compartment NA NA Human Human +DTXSID5023665 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5023665 TK.Half.Life NA 2.42 hours 1compartment NA NA Human Human +DTXSID5023665 Css NA 2.198 mg/L 3compartmentss NA 50% Human Human +DTXSID5023665 Css NA 21.52 mg/L 3compartmentss NA 95% Human Human +DTXSID5023665 Css NA 1.292 mg/L PBTK NA 50% Human Human +DTXSID5023665 Css NA 12.63 mg/L PBTK NA 95% Human Human +DTXSID5023665 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5023665 Fup 0.015 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5023665 Vd NA 0.2088 L/kg 1compartment NA NA Rat Human -DTXSID5023665 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5023665 TK.Half.Life NA 20.82 hours 1compartment NA NA Rat Human -DTXSID5023665 Css NA 14.41 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023665 Css NA 85.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023665 Css NA 7.944 mg/L PBTK NA 50% Rat Human -DTXSID5023665 Css NA 46.31 mg/L PBTK NA 95% Rat Human -DTXSID5023667 Clint NA 32.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023667 Fup NA 0.0971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023667 Vd NA 1.973 L/kg 1compartment NA NA Human Human +DTXSID5023665 Vd NA 0.188 L/kg 1compartment NA NA Rat Human +DTXSID5023665 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5023665 TK.Half.Life NA 1.571 hours 1compartment NA NA Rat Human +DTXSID5023665 Css NA 0.295 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023665 Css NA 2.283 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023665 Css NA 0.167 mg/L PBTK NA 50% Rat Human +DTXSID5023665 Css NA 1.285 mg/L PBTK NA 95% Rat Human +DTXSID5023667 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023667 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023667 Vd NA 2.051 L/kg 1compartment NA NA Human Human DTXSID5023667 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023667 TK.Half.Life NA 4.958 hours 1compartment NA NA Human Human -DTXSID5023667 Css NA 0.2572 mg/L 3compartmentss NA 50% Human Human -DTXSID5023667 Css NA 1.848 mg/L 3compartmentss NA 95% Human Human -DTXSID5023667 Css NA 0.173 mg/L PBTK NA 50% Human Human -DTXSID5023667 Css NA 1.192 mg/L PBTK NA 95% Human Human -DTXSID5023667 Clint NA 32.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023667 Fup NA 0.0971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023667 Vd NA 1.495 L/kg 1compartment NA NA Rat Human +DTXSID5023667 TK.Half.Life NA 7.794 hours 1compartment NA NA Human Human +DTXSID5023667 Css NA 0.439 mg/L 3compartmentss NA 50% Human Human +DTXSID5023667 Css NA 3.076 mg/L 3compartmentss NA 95% Human Human +DTXSID5023667 Css NA 0.2944 mg/L PBTK NA 50% Human Human +DTXSID5023667 Css NA 1.969 mg/L PBTK NA 95% Human Human +DTXSID5023667 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023667 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023667 Vd NA 1.548 L/kg 1compartment NA NA Rat Human DTXSID5023667 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023667 TK.Half.Life NA 1.668 hours 1compartment NA NA Rat Human -DTXSID5023667 Css NA 0.1433 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023667 Css NA 0.8062 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023667 Css NA 0.09232 mg/L PBTK NA 50% Rat Human -DTXSID5023667 Css NA 0.4905 mg/L PBTK NA 95% Rat Human +DTXSID5023667 TK.Half.Life NA 2.525 hours 1compartment NA NA Rat Human +DTXSID5023667 Css NA 0.05638 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023667 Css NA 0.3201 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023667 Css NA 0.03696 mg/L PBTK NA 50% Rat Human +DTXSID5023667 Css NA 0.2007 mg/L PBTK NA 95% Rat Human DTXSID5023740 Clint 0.000936 NA uL/min/million hepatocytes NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human DTXSID5023740 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5023740 Vd NA 2.859 L/kg 1compartment NA NA Human Human -DTXSID5023740 Days.Css NA 1802 Days PBTK NA NA Human Human -DTXSID5023740 TK.Half.Life NA 6633 hours 1compartment NA NA Human Human -DTXSID5023740 Css NA 343.8 mg/L 3compartmentss NA 50% Human Human -DTXSID5023740 Css NA 997.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5023740 Css NA 198.9 mg/L PBTK NA 50% Human Human -DTXSID5023740 Css NA 573.9 mg/L PBTK NA 95% Human Human +DTXSID5023740 Vd NA 1.764 L/kg 1compartment NA NA Human Human +DTXSID5023740 Days.Css NA 239 Days PBTK NA NA Human Human +DTXSID5023740 TK.Half.Life NA 939.9 hours 1compartment NA NA Human Human +DTXSID5023740 Css NA 87.88 mg/L 3compartmentss NA 50% Human Human +DTXSID5023740 Css NA 397.7 mg/L 3compartmentss NA 95% Human Human +DTXSID5023740 Css NA 50.08 mg/L PBTK NA 50% Human Human +DTXSID5023740 Css NA 226.7 mg/L PBTK NA 95% Human Human DTXSID5023740 Clint 0.000936 NA uL/min/million hepatocytes NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human DTXSID5023740 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5023740 Vd NA 2.141 L/kg 1compartment NA NA Rat Human -DTXSID5023740 Days.Css NA 460 Days PBTK NA NA Rat Human -DTXSID5023740 TK.Half.Life NA 583.9 hours 1compartment NA NA Rat Human -DTXSID5023740 Css NA 96.34 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023740 Css NA 219.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023740 Css NA 52.14 mg/L PBTK NA 50% Rat Human -DTXSID5023740 Css NA 118.5 mg/L PBTK NA 95% Rat Human +DTXSID5023740 Vd NA 1.315 L/kg 1compartment NA NA Rat Human +DTXSID5023740 Days.Css NA 57 Days PBTK NA NA Rat Human +DTXSID5023740 TK.Half.Life NA 167.3 hours 1compartment NA NA Rat Human +DTXSID5023740 Css NA 5.281 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023740 Css NA 21.4 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023740 Css NA 3.118 mg/L PBTK NA 50% Rat Human +DTXSID5023740 Css NA 12.62 mg/L PBTK NA 95% Rat Human DTXSID5023742 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5023742 Fup 0.01327 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID5023742 Vd NA 0.4763 L/kg 1compartment NA NA Human Human DTXSID5023742 Days.Css NA 54 Days PBTK NA NA Human Human DTXSID5023742 TK.Half.Life NA 232.1 hours 1compartment NA NA Human Human -DTXSID5023742 Css NA 61.3 mg/L 3compartmentss NA 50% Human Human -DTXSID5023742 Css NA 291.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5023742 Css NA 34.88 mg/L PBTK NA 50% Human Human -DTXSID5023742 Css NA 168.3 mg/L PBTK NA 95% Human Human +DTXSID5023742 Css NA 65.34 mg/L 3compartmentss NA 50% Human Human +DTXSID5023742 Css NA 326.9 mg/L 3compartmentss NA 95% Human Human +DTXSID5023742 Css NA 35.94 mg/L PBTK NA 50% Human Human +DTXSID5023742 Css NA 179.8 mg/L PBTK NA 95% Human Human DTXSID5023742 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5023742 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID5023742 Css NA 65.71 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5023742 Css NA 339.2 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5023744 Clint NA 121.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023744 Fup NA 0.0103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023744 Vd NA 0.1776 L/kg 1compartment NA NA Human Human +DTXSID5023742 Css NA 14.31 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5023742 Css NA 74.91 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5023744 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023744 Fup 0.0606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023744 Vd NA 0.2475 L/kg 1compartment NA NA Human Human DTXSID5023744 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023744 TK.Half.Life NA 0.7233 hours 1compartment NA NA Human Human -DTXSID5023744 Css NA 0.6054 mg/L 3compartmentss NA 50% Human Human -DTXSID5023744 Css NA 6.446 mg/L 3compartmentss NA 95% Human Human -DTXSID5023744 Css NA 0.3516 mg/L PBTK NA 50% Human Human -DTXSID5023744 Css NA 3.694 mg/L PBTK NA 95% Human Human -DTXSID5023744 Clint NA 121.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023744 Fup NA 0.0103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023744 Vd NA 0.1738 L/kg 1compartment NA NA Rat Human +DTXSID5023744 TK.Half.Life NA 2.515 hours 1compartment NA NA Human Human +DTXSID5023744 Css NA 1.494 mg/L 3compartmentss NA 50% Human Human +DTXSID5023744 Css NA 10.06 mg/L 3compartmentss NA 95% Human Human +DTXSID5023744 Css NA 0.896 mg/L PBTK NA 50% Human Human +DTXSID5023744 Css NA 5.876 mg/L PBTK NA 95% Human Human +DTXSID5023744 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023744 Fup 0.0606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023744 Vd NA 0.2398 L/kg 1compartment NA NA Rat Human DTXSID5023744 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023744 TK.Half.Life NA 0.4495 hours 1compartment NA NA Rat Human -DTXSID5023744 Css NA 0.3524 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023744 Css NA 3.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023744 Css NA 0.1917 mg/L PBTK NA 50% Rat Human -DTXSID5023744 Css NA 1.697 mg/L PBTK NA 95% Rat Human -DTXSID5023746 Clint NA 59.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023746 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023746 Vd NA 1.443 L/kg 1compartment NA NA Human Human -DTXSID5023746 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5023746 TK.Half.Life NA 14.37 hours 1compartment NA NA Human Human -DTXSID5023746 Css NA 1.618 mg/L 3compartmentss NA 50% Human Human -DTXSID5023746 Css NA 13.91 mg/L 3compartmentss NA 95% Human Human -DTXSID5023746 Css NA 0.999 mg/L PBTK NA 50% Human Human -DTXSID5023746 Css NA 8.258 mg/L PBTK NA 95% Human Human -DTXSID5023746 Clint NA 59.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023746 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023746 Vd NA 1.059 L/kg 1compartment NA NA Rat Human -DTXSID5023746 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023746 TK.Half.Life NA 5.613 hours 1compartment NA NA Rat Human -DTXSID5023746 Css NA 0.919 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023746 Css NA 6.891 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023746 Css NA 0.5298 mg/L PBTK NA 50% Rat Human -DTXSID5023746 Css NA 3.859 mg/L PBTK NA 95% Rat Human +DTXSID5023744 TK.Half.Life NA 1.514 hours 1compartment NA NA Rat Human +DTXSID5023744 Css NA 0.06727 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023744 Css NA 0.5374 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023744 Css NA 0.03876 mg/L PBTK NA 50% Rat Human +DTXSID5023744 Css NA 0.3045 mg/L PBTK NA 95% Rat Human +DTXSID5023746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023746 Fup 0.0209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023746 Vd NA 3.085 L/kg 1compartment NA NA Human Human +DTXSID5023746 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID5023746 TK.Half.Life NA 76.78 hours 1compartment NA NA Human Human +DTXSID5023746 Css NA 2.664 mg/L 3compartmentss NA 50% Human Human +DTXSID5023746 Css NA 17.75 mg/L 3compartmentss NA 95% Human Human +DTXSID5023746 Css NA 1.841 mg/L PBTK NA 50% Human Human +DTXSID5023746 Css NA 11.87 mg/L PBTK NA 95% Human Human +DTXSID5023746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023746 Fup 0.0209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023746 Vd NA 2.311 L/kg 1compartment NA NA Rat Human +DTXSID5023746 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID5023746 TK.Half.Life NA 10.91 hours 1compartment NA NA Rat Human +DTXSID5023746 Css NA 0.1345 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023746 Css NA 0.8872 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023746 Css NA 0.09025 mg/L PBTK NA 50% Rat Human +DTXSID5023746 Css NA 0.5756 mg/L PBTK NA 95% Rat Human DTXSID5023748 Clint 2.843 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5023748 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5023748 Vd NA 0.9099 L/kg 1compartment NA NA Human Human DTXSID5023748 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5023748 TK.Half.Life NA 2.993 hours 1compartment NA NA Human Human -DTXSID5023748 Css NA 0.263 mg/L 3compartmentss NA 50% Human Human -DTXSID5023748 Css NA 1.624 mg/L 3compartmentss NA 95% Human Human -DTXSID5023748 Css NA 0.253 mg/L PBTK NA 50% Human Human -DTXSID5023748 Css NA 1.224 mg/L PBTK NA 95% Human Human +DTXSID5023748 Css NA 0.2489 mg/L 3compartmentss NA 50% Human Human +DTXSID5023748 Css NA 1.291 mg/L 3compartmentss NA 95% Human Human +DTXSID5023748 Css NA 0.2456 mg/L PBTK NA 50% Human Human +DTXSID5023748 Css NA 1.275 mg/L PBTK NA 95% Human Human DTXSID5023748 Clint 2.843 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID5023748 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5023748 Vd NA 0.8228 L/kg 1compartment NA NA Rat Human DTXSID5023748 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5023748 TK.Half.Life NA 1.469 hours 1compartment NA NA Rat Human -DTXSID5023748 Css NA 0.1202 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023748 Css NA 0.6038 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023748 Css NA 0.1145 mg/L PBTK NA 50% Rat Human -DTXSID5023748 Css NA 0.4194 mg/L PBTK NA 95% Rat Human +DTXSID5023748 Css NA 0.02578 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023748 Css NA 0.09699 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023748 Css NA 0.02643 mg/L PBTK NA 50% Rat Human +DTXSID5023748 Css NA 0.09947 mg/L PBTK NA 95% Rat Human DTXSID5023792 Clint 19.32 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5023792 Fup 0.2659 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5023792 Vd NA 1.733 L/kg 1compartment NA NA Human Human DTXSID5023792 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5023792 TK.Half.Life NA 2.874 hours 1compartment NA NA Human Human -DTXSID5023792 Css NA 0.1152 mg/L 3compartmentss NA 50% Human Human -DTXSID5023792 Css NA 0.7784 mg/L 3compartmentss NA 95% Human Human -DTXSID5023792 Css NA 0.08577 mg/L PBTK NA 50% Human Human -DTXSID5023792 Css NA 0.5322 mg/L PBTK NA 95% Human Human +DTXSID5023792 Css NA 0.1099 mg/L 3compartmentss NA 50% Human Human +DTXSID5023792 Css NA 0.7334 mg/L 3compartmentss NA 95% Human Human +DTXSID5023792 Css NA 0.08202 mg/L PBTK NA 50% Human Human +DTXSID5023792 Css NA 0.5114 mg/L PBTK NA 95% Human Human DTXSID5023792 Clint 19.32 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5023792 Fup 0.2659 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5023792 Vd NA 1.369 L/kg 1compartment NA NA Rat Human DTXSID5023792 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5023792 TK.Half.Life NA 1.075 hours 1compartment NA NA Rat Human -DTXSID5023792 Css NA 0.06166 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023792 Css NA 0.3116 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023792 Css NA 0.04422 mg/L PBTK NA 50% Rat Human -DTXSID5023792 Css NA 0.2084 mg/L PBTK NA 95% Rat Human -DTXSID5023794 Clint NA 3.491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023794 Fup NA 0.0604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023794 Vd NA 1.861 L/kg 1compartment NA NA Human Human -DTXSID5023794 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5023794 TK.Half.Life NA 39.95 hours 1compartment NA NA Human Human -DTXSID5023794 Css NA 3.228 mg/L 3compartmentss NA 50% Human Human -DTXSID5023794 Css NA 17.82 mg/L 3compartmentss NA 95% Human Human -DTXSID5023794 Css NA 2.108 mg/L PBTK NA 50% Human Human -DTXSID5023794 Css NA 10.83 mg/L PBTK NA 95% Human Human -DTXSID5023794 Clint NA 3.491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023794 Fup NA 0.0604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023794 Vd NA 1.399 L/kg 1compartment NA NA Rat Human -DTXSID5023794 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5023794 TK.Half.Life NA 12.73 hours 1compartment NA NA Rat Human -DTXSID5023794 Css NA 1.631 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023794 Css NA 6.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023794 Css NA 1.012 mg/L PBTK NA 50% Rat Human -DTXSID5023794 Css NA 3.806 mg/L PBTK NA 95% Rat Human -DTXSID5023796 Clint NA 21.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023796 Fup NA 0.1531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023796 Vd NA 1.404 L/kg 1compartment NA NA Human Human -DTXSID5023796 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023796 TK.Half.Life NA 2.559 hours 1compartment NA NA Human Human -DTXSID5023796 Css NA 0.1513 mg/L 3compartmentss NA 50% Human Human -DTXSID5023796 Css NA 1.207 mg/L 3compartmentss NA 95% Human Human -DTXSID5023796 Css NA 0.1112 mg/L PBTK NA 50% Human Human -DTXSID5023796 Css NA 0.8153 mg/L PBTK NA 95% Human Human -DTXSID5023796 Clint NA 21.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023796 Fup NA 0.1531 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023796 Vd NA 1.351 L/kg 1compartment NA NA Rat Human -DTXSID5023796 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023796 TK.Half.Life NA 1.4 hours 1compartment NA NA Rat Human -DTXSID5023796 Css NA 0.0817 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023796 Css NA 0.5334 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023796 Css NA 0.05772 mg/L PBTK NA 50% Rat Human -DTXSID5023796 Css NA 0.3297 mg/L PBTK NA 95% Rat Human -DTXSID5023825 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023825 Fup NA 0.6225 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023825 Vd NA 1.358 L/kg 1compartment NA NA Human Human -DTXSID5023825 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5023825 TK.Half.Life NA 15.96 hours 1compartment NA NA Human Human -DTXSID5023825 Css NA 1.203 mg/L 3compartmentss NA 50% Human Human -DTXSID5023825 Css NA 7.973 mg/L 3compartmentss NA 95% Human Human -DTXSID5023825 Css NA 1.05 mg/L PBTK NA 50% Human Human -DTXSID5023825 Css NA 5.217 mg/L PBTK NA 95% Human Human -DTXSID5023825 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023825 Fup NA 0.6225 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023825 Vd NA 1.198 L/kg 1compartment NA NA Rat Human -DTXSID5023825 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023825 TK.Half.Life NA 4.376 hours 1compartment NA NA Rat Human -DTXSID5023825 Css NA 0.317 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023825 Css NA 1.979 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023825 Css NA 0.2679 mg/L PBTK NA 50% Rat Human -DTXSID5023825 Css NA 1.203 mg/L PBTK NA 95% Rat Human +DTXSID5023792 Css NA 0.01356 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023792 Css NA 0.0711 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023792 Css NA 0.01011 mg/L PBTK NA 50% Rat Human +DTXSID5023792 Css NA 0.04991 mg/L PBTK NA 95% Rat Human +DTXSID5023794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023794 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023794 Vd NA 1.897 L/kg 1compartment NA NA Human Human +DTXSID5023794 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5023794 TK.Half.Life NA 5.762 hours 1compartment NA NA Human Human +DTXSID5023794 Css NA 0.3233 mg/L 3compartmentss NA 50% Human Human +DTXSID5023794 Css NA 2.359 mg/L 3compartmentss NA 95% Human Human +DTXSID5023794 Css NA 0.2174 mg/L PBTK NA 50% Human Human +DTXSID5023794 Css NA 1.524 mg/L PBTK NA 95% Human Human +DTXSID5023794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023794 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023794 Vd 1.4 1.441 L/kg 1compartment National Toxicology Program NA Rat Human +DTXSID5023794 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5023794 TK.Half.Life 0.073 1.987 hours 1compartment National Toxicology Program NA Rat Human +DTXSID5023794 Css 0.0033 0.04196 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID5023794 Css 0.0033 0.2317 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID5023794 Css 0.0033 0.0279 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID5023794 Css 0.0033 0.1458 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID5023796 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023796 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023796 Vd NA 3.061 L/kg 1compartment NA NA Human Human +DTXSID5023796 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5023796 TK.Half.Life NA 26.11 hours 1compartment NA NA Human Human +DTXSID5023796 Css NA 0.8284 mg/L 3compartmentss NA 50% Human Human +DTXSID5023796 Css NA 5.36 mg/L 3compartmentss NA 95% Human Human +DTXSID5023796 Css NA 0.6413 mg/L PBTK NA 50% Human Human +DTXSID5023796 Css NA 3.698 mg/L PBTK NA 95% Human Human +DTXSID5023796 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023796 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023796 Vd NA 2.502 L/kg 1compartment NA NA Rat Human +DTXSID5023796 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5023796 TK.Half.Life NA 7.007 hours 1compartment NA NA Rat Human +DTXSID5023796 Css NA 0.03906 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023796 Css NA 0.2526 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023796 Css NA 0.0299 mg/L PBTK NA 50% Rat Human +DTXSID5023796 Css NA 0.1758 mg/L PBTK NA 95% Rat Human DTXSID5023871 Clint 33.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5023871 Fup 3.02e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5023871 Vd NA 0.7524 L/kg 1compartment NA NA Human Human +DTXSID5023871 Vd NA 0.743 L/kg 1compartment NA NA Human Human DTXSID5023871 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID5023871 TK.Half.Life NA 53.57 hours 1compartment NA NA Human Human -DTXSID5023871 Css NA 5.38 mg/L 3compartmentss NA 50% Human Human -DTXSID5023871 Css NA 31.92 mg/L 3compartmentss NA 95% Human Human -DTXSID5023871 Css NA 3.24 mg/L PBTK NA 50% Human Human -DTXSID5023871 Css NA 18.77 mg/L PBTK NA 95% Human Human +DTXSID5023871 TK.Half.Life NA 53.86 hours 1compartment NA NA Human Human +DTXSID5023871 Css NA 5.451 mg/L 3compartmentss NA 50% Human Human +DTXSID5023871 Css NA 33.79 mg/L 3compartmentss NA 95% Human Human +DTXSID5023871 Css NA 3.286 mg/L PBTK NA 50% Human Human +DTXSID5023871 Css NA 19.83 mg/L PBTK NA 95% Human Human DTXSID5023871 Clint 33.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5023871 Fup 3.02e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5023871 Vd NA 0.5509 L/kg 1compartment NA NA Rat Human +DTXSID5023871 Vd NA 0.5443 L/kg 1compartment NA NA Rat Human DTXSID5023871 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5023871 TK.Half.Life NA 27.38 hours 1compartment NA NA Rat Human -DTXSID5023871 Css NA 3.915 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023871 Css NA 12.35 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023871 Css NA 2.177 mg/L PBTK NA 50% Rat Human -DTXSID5023871 Css NA 7.013 mg/L PBTK NA 95% Rat Human -DTXSID5023875 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023875 Fup NA 0.5476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023875 Vd NA 0.5135 L/kg 1compartment NA NA Human Human -DTXSID5023875 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5023875 TK.Half.Life NA 6.064 hours 1compartment NA NA Human Human -DTXSID5023875 Css NA 1.392 mg/L 3compartmentss NA 50% Human Human -DTXSID5023875 Css NA 8.572 mg/L 3compartmentss NA 95% Human Human -DTXSID5023875 Css NA 1.053 mg/L PBTK NA 50% Human Human -DTXSID5023875 Css NA 5.312 mg/L PBTK NA 95% Human Human -DTXSID5023875 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023875 Fup NA 0.5476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023875 Vd NA 0.5439 L/kg 1compartment NA NA Rat Human -DTXSID5023875 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023875 TK.Half.Life NA 2.189 hours 1compartment NA NA Rat Human -DTXSID5023875 Css NA 0.3712 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023875 Css NA 2.108 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023875 Css NA 0.2668 mg/L PBTK NA 50% Rat Human -DTXSID5023875 Css NA 1.22 mg/L PBTK NA 95% Rat Human +DTXSID5023871 TK.Half.Life NA 27.54 hours 1compartment NA NA Rat Human +DTXSID5023871 Css NA 0.9001 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023871 Css NA 2.912 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023871 Css NA 0.5178 mg/L PBTK NA 50% Rat Human +DTXSID5023871 Css NA 1.676 mg/L PBTK NA 95% Rat Human +DTXSID50238710 Clint 6.61 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50238710 Fup 0.0661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50238710 Vd NA 1.6 L/kg 1compartment NA NA Human Human +DTXSID50238710 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID50238710 TK.Half.Life NA 16.57 hours 1compartment NA NA Human Human +DTXSID50238710 Css NA 1.411 mg/L 3compartmentss NA 50% Human Human +DTXSID50238710 Css NA 8.557 mg/L 3compartmentss NA 95% Human Human +DTXSID50238710 Css NA 0.9227 mg/L PBTK NA 50% Human Human +DTXSID50238710 Css NA 5.316 mg/L PBTK NA 95% Human Human +DTXSID50238710 Clint 6.61 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50238710 Fup 0.0661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50238710 Vd NA 1.216 L/kg 1compartment NA NA Rat Human +DTXSID50238710 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50238710 TK.Half.Life NA 6.178 hours 1compartment NA NA Rat Human +DTXSID50238710 Css NA 0.1749 mg/L 3compartmentss NA 50% Rat Human +DTXSID50238710 Css NA 0.7463 mg/L 3compartmentss NA 95% Rat Human +DTXSID50238710 Css NA 0.1115 mg/L PBTK NA 50% Rat Human +DTXSID50238710 Css NA 0.4541 mg/L PBTK NA 95% Rat Human DTXSID5023877 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5023877 Fup 0.4532 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5023877 Vd NA 0.952 L/kg 1compartment NA NA Human Human DTXSID5023877 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID5023877 TK.Half.Life NA 14.27 hours 1compartment NA NA Human Human -DTXSID5023877 Css NA 1.569 mg/L 3compartmentss NA 50% Human Human -DTXSID5023877 Css NA 7.631 mg/L 3compartmentss NA 95% Human Human -DTXSID5023877 Css NA 1.252 mg/L PBTK NA 50% Human Human -DTXSID5023877 Css NA 4.989 mg/L PBTK NA 95% Human Human +DTXSID5023877 Css NA 1.531 mg/L 3compartmentss NA 50% Human Human +DTXSID5023877 Css NA 7.383 mg/L 3compartmentss NA 95% Human Human +DTXSID5023877 Css NA 1.217 mg/L PBTK NA 50% Human Human +DTXSID5023877 Css NA 4.845 mg/L PBTK NA 95% Human Human DTXSID5023877 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5023877 Fup 0.4532 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5023877 Vd NA 0.8679 L/kg 1compartment NA NA Rat Human DTXSID5023877 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5023877 TK.Half.Life NA 4.273 hours 1compartment NA NA Rat Human -DTXSID5023877 Css NA 0.4227 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023877 Css NA 1.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023877 Css NA 0.3246 mg/L PBTK NA 50% Rat Human -DTXSID5023877 Css NA 1.078 mg/L PBTK NA 95% Rat Human +DTXSID5023877 Css NA 0.09686 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023877 Css NA 0.3985 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023877 Css NA 0.07686 mg/L PBTK NA 50% Rat Human +DTXSID5023877 Css NA 0.2514 mg/L PBTK NA 95% Rat Human DTXSID5023902 Clint 18.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5023902 Fup 0.01121 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5023902 Vd NA 8.851 L/kg 1compartment NA NA Human Human DTXSID5023902 Days.Css NA 56 Days PBTK NA NA Human Human DTXSID5023902 TK.Half.Life NA 287.9 hours 1compartment NA NA Human Human -DTXSID5023902 Css NA 4.783 mg/L 3compartmentss NA 50% Human Human -DTXSID5023902 Css NA 29.28 mg/L 3compartmentss NA 95% Human Human -DTXSID5023902 Css NA 2.79 mg/L PBTK NA 50% Human Human -DTXSID5023902 Css NA 17.04 mg/L PBTK NA 95% Human Human +DTXSID5023902 Css NA 4.045 mg/L 3compartmentss NA 50% Human Human +DTXSID5023902 Css NA 25.95 mg/L 3compartmentss NA 95% Human Human +DTXSID5023902 Css NA 2.718 mg/L PBTK NA 50% Human Human +DTXSID5023902 Css NA 17.44 mg/L PBTK NA 95% Human Human DTXSID5023902 Clint 18.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5023902 Fup 0.01121 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5023902 Vd NA 8.574 L/kg 1compartment NA NA Rat Human DTXSID5023902 Days.Css NA 43 Days PBTK NA NA Rat Human DTXSID5023902 TK.Half.Life NA 52.83 hours 1compartment NA NA Rat Human -DTXSID5023902 Css NA 2.754 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023902 Css NA 13.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023902 Css NA 1.497 mg/L PBTK NA 50% Rat Human -DTXSID5023902 Css NA 7.147 mg/L PBTK NA 95% Rat Human +DTXSID5023902 Css NA 0.5018 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023902 Css NA 2.74 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023902 Css NA 0.3492 mg/L PBTK NA 50% Rat Human +DTXSID5023902 Css NA 1.907 mg/L PBTK NA 95% Rat Human DTXSID5023950 Clint 26.74 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5023950 Fup NA 0.0095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023950 Vd NA 2.768 L/kg 1compartment NA NA Human Human -DTXSID5023950 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID5023950 TK.Half.Life NA 46.43 hours 1compartment NA NA Human Human -DTXSID5023950 Css NA 2.28 mg/L 3compartmentss NA 50% Human Human -DTXSID5023950 Css NA 16.02 mg/L 3compartmentss NA 95% Human Human -DTXSID5023950 Css NA 1.532 mg/L PBTK NA 50% Human Human -DTXSID5023950 Css NA 10.3 mg/L PBTK NA 95% Human Human +DTXSID5023950 Fup 0.0333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5023950 Vd NA 3.432 L/kg 1compartment NA NA Human Human +DTXSID5023950 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID5023950 TK.Half.Life NA 84.21 hours 1compartment NA NA Human Human +DTXSID5023950 Css NA 2.682 mg/L 3compartmentss NA 50% Human Human +DTXSID5023950 Css NA 15.85 mg/L 3compartmentss NA 95% Human Human +DTXSID5023950 Css NA 1.912 mg/L PBTK NA 50% Human Human +DTXSID5023950 Css NA 11.22 mg/L PBTK NA 95% Human Human DTXSID5023950 Clint 26.74 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5023950 Fup NA 0.0095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023950 Vd NA 2.068 L/kg 1compartment NA NA Rat Human -DTXSID5023950 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5023950 TK.Half.Life NA 9.338 hours 1compartment NA NA Rat Human -DTXSID5023950 Css NA 1.294 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023950 Css NA 7.334 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023950 Css NA 0.8248 mg/L PBTK NA 50% Rat Human -DTXSID5023950 Css NA 4.536 mg/L PBTK NA 95% Rat Human -DTXSID5023954 Clint NA 156 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023954 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5023954 Vd NA 3.582 L/kg 1compartment NA NA Human Human -DTXSID5023954 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5023954 TK.Half.Life NA 17.49 hours 1compartment NA NA Human Human -DTXSID5023954 Css NA 0.4712 mg/L 3compartmentss NA 50% Human Human -DTXSID5023954 Css NA 2.577 mg/L 3compartmentss NA 95% Human Human -DTXSID5023954 Css NA 0.3421 mg/L PBTK NA 50% Human Human -DTXSID5023954 Css NA 1.832 mg/L PBTK NA 95% Human Human -DTXSID5023954 Clint NA 156 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023954 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5023954 Vd NA 2.697 L/kg 1compartment NA NA Rat Human -DTXSID5023954 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5023954 TK.Half.Life NA 2.834 hours 1compartment NA NA Rat Human -DTXSID5023954 Css NA 0.2665 mg/L 3compartmentss NA 50% Rat Human -DTXSID5023954 Css NA 1.135 mg/L 3compartmentss NA 95% Rat Human -DTXSID5023954 Css NA 0.1844 mg/L PBTK NA 50% Rat Human -DTXSID5023954 Css NA 0.7759 mg/L PBTK NA 95% Rat Human +DTXSID5023950 Fup 0.0333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5023950 Vd NA 2.581 L/kg 1compartment NA NA Rat Human +DTXSID5023950 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID5023950 TK.Half.Life NA 11.29 hours 1compartment NA NA Rat Human +DTXSID5023950 Css NA 0.3506 mg/L 3compartmentss NA 50% Rat Human +DTXSID5023950 Css NA 1.704 mg/L 3compartmentss NA 95% Rat Human +DTXSID5023950 Css NA 0.2482 mg/L PBTK NA 50% Rat Human +DTXSID5023950 Css NA 1.206 mg/L PBTK NA 95% Rat Human DTXSID5024001 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024001 Fup NA 0.3546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024001 Vd NA 0.5322 L/kg 1compartment NA NA Human Human -DTXSID5024001 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5024001 TK.Half.Life NA 9.711 hours 1compartment NA NA Human Human -DTXSID5024001 Css NA 2.066 mg/L 3compartmentss NA 50% Human Human -DTXSID5024001 Css NA 8.362 mg/L 3compartmentss NA 95% Human Human -DTXSID5024001 Css NA 1.513 mg/L PBTK NA 50% Human Human -DTXSID5024001 Css NA 5.372 mg/L PBTK NA 95% Human Human +DTXSID5024001 Vd NA 0.5014 L/kg 1compartment NA NA Human Human +DTXSID5024001 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5024001 TK.Half.Life NA 9.148 hours 1compartment NA NA Human Human +DTXSID5024001 Css NA 1.742 mg/L 3compartmentss NA 50% Human Human +DTXSID5024001 Css NA 7.303 mg/L 3compartmentss NA 95% Human Human +DTXSID5024001 Css NA 1.266 mg/L PBTK NA 50% Human Human +DTXSID5024001 Css NA 4.657 mg/L PBTK NA 95% Human Human DTXSID5024001 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024001 Fup NA 0.3546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024001 Vd NA 0.5408 L/kg 1compartment NA NA Rat Human +DTXSID5024001 Vd NA 0.5122 L/kg 1compartment NA NA Rat Human DTXSID5024001 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024001 TK.Half.Life NA 3.362 hours 1compartment NA NA Rat Human -DTXSID5024001 Css NA 0.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024001 Css NA 1.99 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024001 Css NA 0.3928 mg/L PBTK NA 50% Rat Human -DTXSID5024001 Css NA 1.181 mg/L PBTK NA 95% Rat Human -DTXSID5024051 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5024051 Fup 0.9727 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5024051 Vd NA 1.37 L/kg 1compartment NA NA Human Human -DTXSID5024051 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024051 TK.Half.Life NA 9.805 hours 1compartment NA NA Human Human -DTXSID5024051 Css NA 0.8066 mg/L 3compartmentss NA 50% Human Human -DTXSID5024051 Css NA 4.772 mg/L 3compartmentss NA 95% Human Human -DTXSID5024051 Css NA 0.7538 mg/L PBTK NA 50% Human Human -DTXSID5024051 Css NA 3.244 mg/L PBTK NA 95% Human Human -DTXSID5024051 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5024051 Fup 0.9727 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5024051 Vd NA 1.28 L/kg 1compartment NA NA Rat Human -DTXSID5024051 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024051 TK.Half.Life NA 2.953 hours 1compartment NA NA Rat Human -DTXSID5024051 Css NA 0.2033 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024051 Css NA 1.208 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024051 Css NA 0.1866 mg/L PBTK NA 50% Rat Human -DTXSID5024051 Css NA 0.764 mg/L PBTK NA 95% Rat Human +DTXSID5024001 TK.Half.Life NA 3.184 hours 1compartment NA NA Rat Human +DTXSID5024001 Css NA 0.03184 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024001 Css NA 0.1972 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024001 Css NA 0.02206 mg/L PBTK NA 50% Rat Human +DTXSID5024001 Css NA 0.1244 mg/L PBTK NA 95% Rat Human DTXSID5024055 Clint NA 0.02298 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024055 Fup NA 0.8741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024055 Vd NA 0.7567 L/kg 1compartment NA NA Human Human +DTXSID5024055 Vd NA 0.909 L/kg 1compartment NA NA Human Human DTXSID5024055 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024055 TK.Half.Life NA 5.403 hours 1compartment NA NA Human Human -DTXSID5024055 Css NA 0.905 mg/L 3compartmentss NA 50% Human Human -DTXSID5024055 Css NA 5.376 mg/L 3compartmentss NA 95% Human Human -DTXSID5024055 Css NA 0.7492 mg/L PBTK NA 50% Human Human -DTXSID5024055 Css NA 3.444 mg/L PBTK NA 95% Human Human +DTXSID5024055 TK.Half.Life NA 6.539 hours 1compartment NA NA Human Human +DTXSID5024055 Css NA 0.7362 mg/L 3compartmentss NA 50% Human Human +DTXSID5024055 Css NA 4.47 mg/L 3compartmentss NA 95% Human Human +DTXSID5024055 Css NA 0.6372 mg/L PBTK NA 50% Human Human +DTXSID5024055 Css NA 2.931 mg/L PBTK NA 95% Human Human DTXSID5024055 Clint NA 0.02298 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024055 Fup NA 0.8741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024055 Vd NA 0.7857 L/kg 1compartment NA NA Rat Human +DTXSID5024055 Vd NA 0.9131 L/kg 1compartment NA NA Rat Human DTXSID5024055 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024055 TK.Half.Life NA 1.946 hours 1compartment NA NA Rat Human -DTXSID5024055 Css NA 0.2334 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024055 Css NA 1.272 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024055 Css NA 0.1885 mg/L PBTK NA 50% Rat Human -DTXSID5024055 Css NA 0.7702 mg/L PBTK NA 95% Rat Human +DTXSID5024055 TK.Half.Life NA 2.266 hours 1compartment NA NA Rat Human +DTXSID5024055 Css NA 0.01434 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024055 Css NA 0.113 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024055 Css NA 0.01194 mg/L PBTK NA 50% Rat Human +DTXSID5024055 Css NA 0.07407 mg/L PBTK NA 95% Rat Human DTXSID5024057 Clint NA 0.1015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024057 Fup NA 0.5616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024057 Vd NA 1.547 L/kg 1compartment NA NA Human Human DTXSID5024057 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID5024057 TK.Half.Life NA 15.28 hours 1compartment NA NA Human Human -DTXSID5024057 Css NA 0.9324 mg/L 3compartmentss NA 50% Human Human -DTXSID5024057 Css NA 6.893 mg/L 3compartmentss NA 95% Human Human -DTXSID5024057 Css NA 0.8678 mg/L PBTK NA 50% Human Human -DTXSID5024057 Css NA 4.523 mg/L PBTK NA 95% Human Human +DTXSID5024057 Css NA 0.7884 mg/L 3compartmentss NA 50% Human Human +DTXSID5024057 Css NA 6.198 mg/L 3compartmentss NA 95% Human Human +DTXSID5024057 Css NA 0.7306 mg/L PBTK NA 50% Human Human +DTXSID5024057 Css NA 4.047 mg/L PBTK NA 95% Human Human DTXSID5024057 Clint NA 0.1015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024057 Fup NA 0.5616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024057 Vd NA 1.563 L/kg 1compartment NA NA Rat Human DTXSID5024057 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5024057 TK.Half.Life NA 5.677 hours 1compartment NA NA Rat Human -DTXSID5024057 Css NA 0.2694 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024057 Css NA 1.939 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024057 Css NA 0.2422 mg/L PBTK NA 50% Rat Human -DTXSID5024057 Css NA 1.192 mg/L PBTK NA 95% Rat Human +DTXSID5024057 Css NA 0.01656 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024057 Css NA 0.1553 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024057 Css NA 0.01494 mg/L PBTK NA 50% Rat Human +DTXSID5024057 Css NA 0.1048 mg/L PBTK NA 95% Rat Human DTXSID5024059 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5024059 Fup 0.1427 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5024059 Vd NA 1.259 L/kg 1compartment NA NA Human Human DTXSID5024059 Days.Css NA 12 Days PBTK NA NA Human Human DTXSID5024059 TK.Half.Life NA 70.09 hours 1compartment NA NA Human Human -DTXSID5024059 Css NA 7.504 mg/L 3compartmentss NA 50% Human Human -DTXSID5024059 Css NA 31.39 mg/L 3compartmentss NA 95% Human Human -DTXSID5024059 Css NA 5.095 mg/L PBTK NA 50% Human Human -DTXSID5024059 Css NA 19.36 mg/L PBTK NA 95% Human Human +DTXSID5024059 Css NA 7.274 mg/L 3compartmentss NA 50% Human Human +DTXSID5024059 Css NA 29.74 mg/L 3compartmentss NA 95% Human Human +DTXSID5024059 Css NA 4.926 mg/L PBTK NA 50% Human Human +DTXSID5024059 Css NA 18.23 mg/L PBTK NA 95% Human Human DTXSID5024059 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5024059 Fup 0.1427 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5024059 Vd NA 0.9903 L/kg 1compartment NA NA Rat Human DTXSID5024059 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID5024059 TK.Half.Life NA 16.12 hours 1compartment NA NA Rat Human -DTXSID5024059 Css NA 2.072 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024059 Css NA 7.721 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024059 Css NA 1.328 mg/L PBTK NA 50% Rat Human -DTXSID5024059 Css NA 4.405 mg/L PBTK NA 95% Rat Human +DTXSID5024059 Css NA 0.4705 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024059 Css NA 1.688 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024059 Css NA 0.3123 mg/L PBTK NA 50% Rat Human +DTXSID5024059 Css NA 0.9992 mg/L PBTK NA 95% Rat Human DTXSID5024134 Clint NA 0.1151 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024134 Fup NA 0.0566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024134 Vd NA 2.489 L/kg 1compartment NA NA Human Human -DTXSID5024134 Days.Css NA 166 Days PBTK NA NA Human Human +DTXSID5024134 Days.Css NA 167 Days PBTK NA NA Human Human DTXSID5024134 TK.Half.Life NA 676.9 hours 1compartment NA NA Human Human -DTXSID5024134 Css NA 35.6 mg/L 3compartmentss NA 50% Human Human -DTXSID5024134 Css NA 114.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5024134 Css NA 24.11 mg/L PBTK NA 50% Human Human -DTXSID5024134 Css NA 72.02 mg/L PBTK NA 95% Human Human +DTXSID5024134 Css NA 30.62 mg/L 3compartmentss NA 50% Human Human +DTXSID5024134 Css NA 102.2 mg/L 3compartmentss NA 95% Human Human +DTXSID5024134 Css NA 20.68 mg/L PBTK NA 50% Human Human +DTXSID5024134 Css NA 64.14 mg/L PBTK NA 95% Human Human DTXSID5024134 Clint NA 0.1151 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024134 Fup NA 0.0566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024134 Vd NA 1.866 L/kg 1compartment NA NA Rat Human DTXSID5024134 Days.Css NA 47 Days PBTK NA NA Rat Human DTXSID5024134 TK.Half.Life NA 94.96 hours 1compartment NA NA Rat Human -DTXSID5024134 Css NA 11.42 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024134 Css NA 29.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024134 Css NA 7.32 mg/L PBTK NA 50% Rat Human -DTXSID5024134 Css NA 17.49 mg/L PBTK NA 95% Rat Human +DTXSID5024134 Css NA 0.8712 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024134 Css NA 4.107 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024134 Css NA 0.5699 mg/L PBTK NA 50% Rat Human +DTXSID5024134 Css NA 2.526 mg/L PBTK NA 95% Rat Human +DTXSID50241486 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50241486 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50241486 Vd NA 1.45 L/kg 1compartment NA NA Human Human +DTXSID50241486 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID50241486 TK.Half.Life NA 12.47 hours 1compartment NA NA Human Human +DTXSID50241486 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human +DTXSID50241486 Css NA 5.667 mg/L 3compartmentss NA 95% Human Human +DTXSID50241486 Css NA 0.72 mg/L PBTK NA 50% Human Human +DTXSID50241486 Css NA 3.597 mg/L PBTK NA 95% Human Human +DTXSID50241486 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50241486 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50241486 Vd NA 1.139 L/kg 1compartment NA NA Rat Human +DTXSID50241486 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50241486 TK.Half.Life NA 4.744 hours 1compartment NA NA Rat Human +DTXSID50241486 Css NA 0.1163 mg/L 3compartmentss NA 50% Rat Human +DTXSID50241486 Css NA 0.4789 mg/L 3compartmentss NA 95% Rat Human +DTXSID50241486 Css NA 0.07964 mg/L PBTK NA 50% Rat Human +DTXSID50241486 Css NA 0.294 mg/L PBTK NA 95% Rat Human +DTXSID50241749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50241749 Fup 0.0063 NA NA https://doi.org/10.1002/bdd.711 NA Human Human +DTXSID50241749 Vd NA 1.008 L/kg 1compartment NA NA Human Human +DTXSID50241749 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID50241749 TK.Half.Life NA 13.37 hours 1compartment NA NA Human Human +DTXSID50241749 Css NA 1.867 mg/L 3compartmentss NA 50% Human Human +DTXSID50241749 Css NA 17.57 mg/L 3compartmentss NA 95% Human Human +DTXSID50241749 Css NA 1.382 mg/L PBTK NA 50% Human Human +DTXSID50241749 Css NA 13 mg/L PBTK NA 95% Human Human +DTXSID50241749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50241749 Fup 0.0063 NA NA https://doi.org/10.1002/bdd.711 NA Rat Human +DTXSID50241749 Vd NA 1.967 L/kg 1compartment NA NA Rat Human +DTXSID50241749 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50241749 TK.Half.Life NA 3.49 hours 1compartment NA NA Rat Human +DTXSID50241749 Css NA 0.0568 mg/L 3compartmentss NA 50% Rat Human +DTXSID50241749 Css NA 0.3566 mg/L 3compartmentss NA 95% Rat Human +DTXSID50241749 Css NA 0.04352 mg/L PBTK NA 50% Rat Human +DTXSID50241749 Css NA 0.2731 mg/L PBTK NA 95% Rat Human DTXSID5024182 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024182 Fup NA 0.821 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024182 Vd NA 0.7222 L/kg 1compartment NA NA Human Human DTXSID5024182 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5024182 TK.Half.Life NA 5.696 hours 1compartment NA NA Human Human -DTXSID5024182 Css NA 0.9838 mg/L 3compartmentss NA 50% Human Human -DTXSID5024182 Css NA 5.689 mg/L 3compartmentss NA 95% Human Human -DTXSID5024182 Css NA 0.8044 mg/L PBTK NA 50% Human Human -DTXSID5024182 Css NA 3.741 mg/L PBTK NA 95% Human Human +DTXSID5024182 Css NA 0.8318 mg/L 3compartmentss NA 50% Human Human +DTXSID5024182 Css NA 5.112 mg/L 3compartmentss NA 95% Human Human +DTXSID5024182 Css NA 0.6823 mg/L PBTK NA 50% Human Human +DTXSID5024182 Css NA 3.31 mg/L PBTK NA 95% Human Human DTXSID5024182 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024182 Fup NA 0.821 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024182 Vd NA 0.751 L/kg 1compartment NA NA Rat Human DTXSID5024182 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5024182 TK.Half.Life NA 2.018 hours 1compartment NA NA Rat Human -DTXSID5024182 Css NA 0.2505 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024182 Css NA 1.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024182 Css NA 0.1994 mg/L PBTK NA 50% Rat Human -DTXSID5024182 Css NA 0.8903 mg/L PBTK NA 95% Rat Human +DTXSID5024182 Css NA 0.01575 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024182 Css NA 0.1203 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024182 Css NA 0.01236 mg/L PBTK NA 50% Rat Human +DTXSID5024182 Css NA 0.07772 mg/L PBTK NA 95% Rat Human DTXSID5024211 Clint 15.15 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID5024211 Fup NA 0.0529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024211 Vd NA 1.977 L/kg 1compartment NA NA Human Human +DTXSID5024211 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024211 Vd NA 2.767 L/kg 1compartment NA NA Human Human DTXSID5024211 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5024211 TK.Half.Life NA 13.74 hours 1compartment NA NA Human Human -DTXSID5024211 Css NA 0.9801 mg/L 3compartmentss NA 50% Human Human -DTXSID5024211 Css NA 6.498 mg/L 3compartmentss NA 95% Human Human -DTXSID5024211 Css NA 0.6423 mg/L PBTK NA 50% Human Human -DTXSID5024211 Css NA 4.1 mg/L PBTK NA 95% Human Human +DTXSID5024211 TK.Half.Life NA 18.84 hours 1compartment NA NA Human Human +DTXSID5024211 Css NA 0.7752 mg/L 3compartmentss NA 50% Human Human +DTXSID5024211 Css NA 4.777 mg/L 3compartmentss NA 95% Human Human +DTXSID5024211 Css NA 0.5443 mg/L PBTK NA 50% Human Human +DTXSID5024211 Css NA 3.184 mg/L PBTK NA 95% Human Human DTXSID5024211 Clint 15.15 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID5024211 Fup NA 0.0529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024211 Vd NA 1.487 L/kg 1compartment NA NA Rat Human +DTXSID5024211 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024211 Vd NA 2.091 L/kg 1compartment NA NA Rat Human DTXSID5024211 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024211 TK.Half.Life NA 4.533 hours 1compartment NA NA Rat Human -DTXSID5024211 Css NA 0.5319 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024211 Css NA 2.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024211 Css NA 0.3317 mg/L PBTK NA 50% Rat Human -DTXSID5024211 Css NA 1.699 mg/L PBTK NA 95% Rat Human +DTXSID5024211 TK.Half.Life NA 4.085 hours 1compartment NA NA Rat Human +DTXSID5024211 Css NA 0.09941 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024211 Css NA 0.4958 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024211 Css NA 0.06875 mg/L PBTK NA 50% Rat Human +DTXSID5024211 Css NA 0.3352 mg/L PBTK NA 95% Rat Human DTXSID5024261 Clint 23.82 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5024261 Fup 0.0477 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5024261 Vd NA 1.121 L/kg 1compartment NA NA Human Human DTXSID5024261 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5024261 TK.Half.Life NA 4.761 hours 1compartment NA NA Human Human -DTXSID5024261 Css NA 0.5906 mg/L 3compartmentss NA 50% Human Human -DTXSID5024261 Css NA 4.839 mg/L 3compartmentss NA 95% Human Human -DTXSID5024261 Css NA 0.3698 mg/L PBTK NA 50% Human Human -DTXSID5024261 Css NA 2.924 mg/L PBTK NA 95% Human Human +DTXSID5024261 Css NA 0.5736 mg/L 3compartmentss NA 50% Human Human +DTXSID5024261 Css NA 4.796 mg/L 3compartmentss NA 95% Human Human +DTXSID5024261 Css NA 0.3604 mg/L PBTK NA 50% Human Human +DTXSID5024261 Css NA 2.891 mg/L PBTK NA 95% Human Human DTXSID5024261 Clint 23.82 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5024261 Fup 0.0477 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5024261 Vd NA 0.8494 L/kg 1compartment NA NA Rat Human DTXSID5024261 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5024261 TK.Half.Life NA 2.021 hours 1compartment NA NA Rat Human -DTXSID5024261 Css NA 0.3376 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024261 Css NA 2.084 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024261 Css NA 0.1984 mg/L PBTK NA 50% Rat Human -DTXSID5024261 Css NA 1.178 mg/L PBTK NA 95% Rat Human -DTXSID5024263 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024263 Fup NA 0.4796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024263 Vd NA 0.4566 L/kg 1compartment NA NA Human Human -DTXSID5024263 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024263 TK.Half.Life NA 6.161 hours 1compartment NA NA Human Human -DTXSID5024263 Css NA 1.576 mg/L 3compartmentss NA 50% Human Human -DTXSID5024263 Css NA 7.543 mg/L 3compartmentss NA 95% Human Human -DTXSID5024263 Css NA 1.147 mg/L PBTK NA 50% Human Human -DTXSID5024263 Css NA 4.727 mg/L PBTK NA 95% Human Human -DTXSID5024263 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024263 Fup NA 0.4796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024263 Vd NA 0.4883 L/kg 1compartment NA NA Rat Human -DTXSID5024263 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024263 TK.Half.Life NA 2.245 hours 1compartment NA NA Rat Human -DTXSID5024263 Css NA 0.4278 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024263 Css NA 1.808 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024263 Css NA 0.297 mg/L PBTK NA 50% Rat Human -DTXSID5024263 Css NA 1.055 mg/L PBTK NA 95% Rat Human -DTXSID5024392 Clint NA 0.8275 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024392 Fup NA 0.1568 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024392 Vd NA 0.4087 L/kg 1compartment NA NA Human Human +DTXSID5024261 Css NA 0.07425 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024261 Css NA 0.4803 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024261 Css NA 0.04524 mg/L PBTK NA 50% Rat Human +DTXSID5024261 Css NA 0.2861 mg/L PBTK NA 95% Rat Human +DTXSID5024344 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human +DTXSID5024344 Fup 0.00939 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024344 Vd NA 2.563 L/kg 1compartment NA NA Human Human +DTXSID5024344 Days.Css NA 1797 Days PBTK NA NA Human Human +DTXSID5024344 TK.Half.Life NA 6583 hours 1compartment NA NA Human Human +DTXSID5024344 Css NA 336.8 mg/L 3compartmentss NA 50% Human Human +DTXSID5024344 Css NA 1200 mg/L 3compartmentss NA 95% Human Human +DTXSID5024344 Css NA 223.6 mg/L PBTK NA 50% Human Human +DTXSID5024344 Css NA 739.2 mg/L PBTK NA 95% Human Human +DTXSID5024344 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human +DTXSID5024344 Fup 0.00939 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024344 Vd NA 1.911 L/kg 1compartment NA NA Rat Human +DTXSID5024344 Days.Css NA 454 Days PBTK NA NA Rat Human +DTXSID5024344 TK.Half.Life NA 740.4 hours 1compartment NA NA Rat Human +DTXSID5024344 Css NA 21.5 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024344 Css NA 64.05 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024344 Css NA 13.97 mg/L PBTK NA 50% Rat Human +DTXSID5024344 Css NA 37.97 mg/L PBTK NA 95% Rat Human +DTXSID5024392 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024392 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024392 Vd NA 0.5524 L/kg 1compartment NA NA Human Human DTXSID5024392 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024392 TK.Half.Life NA 7.24 hours 1compartment NA NA Human Human -DTXSID5024392 Css NA 2.448 mg/L 3compartmentss NA 50% Human Human -DTXSID5024392 Css NA 11.62 mg/L 3compartmentss NA 95% Human Human -DTXSID5024392 Css NA 1.568 mg/L PBTK NA 50% Human Human -DTXSID5024392 Css NA 6.911 mg/L PBTK NA 95% Human Human -DTXSID5024392 Clint NA 0.8275 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024392 Fup NA 0.1568 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024392 Vd NA 0.3774 L/kg 1compartment NA NA Rat Human +DTXSID5024392 TK.Half.Life NA 0.7551 hours 1compartment NA NA Human Human +DTXSID5024392 Css NA 0.07365 mg/L 3compartmentss NA 50% Human Human +DTXSID5024392 Css NA 0.5652 mg/L 3compartmentss NA 95% Human Human +DTXSID5024392 Css NA 0.05041 mg/L PBTK NA 50% Human Human +DTXSID5024392 Css NA 0.3632 mg/L PBTK NA 95% Human Human +DTXSID5024392 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024392 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024392 Vd NA 0.5107 L/kg 1compartment NA NA Rat Human DTXSID5024392 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024392 TK.Half.Life NA 3.199 hours 1compartment NA NA Rat Human -DTXSID5024392 Css NA 0.9918 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024392 Css NA 3.806 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024392 Css NA 0.5938 mg/L PBTK NA 50% Rat Human -DTXSID5024392 Css NA 2.126 mg/L PBTK NA 95% Rat Human +DTXSID5024392 TK.Half.Life NA 0.3697 hours 1compartment NA NA Rat Human +DTXSID5024392 Css NA 0.009382 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024392 Css NA 0.05385 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024392 Css NA 0.006368 mg/L PBTK NA 50% Rat Human +DTXSID5024392 Css NA 0.03378 mg/L PBTK NA 95% Rat Human DTXSID5024394 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024394 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024394 Vd NA 0.3755 L/kg 1compartment NA NA Human Human DTXSID5024394 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5024394 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID5024394 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID5024394 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID5024394 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID5024394 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID5024394 Css NA 2.011 mg/L 3compartmentss NA 50% Human Human +DTXSID5024394 Css NA 8.544 mg/L 3compartmentss NA 95% Human Human +DTXSID5024394 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID5024394 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID5024394 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024394 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024394 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human DTXSID5024394 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5024394 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID5024394 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024394 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024394 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID5024394 Css NA 1.313 mg/L PBTK NA 95% Rat Human -DTXSID5024471 Clint NA 29.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024471 Fup NA 0.3363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024471 Vd NA 1.306 L/kg 1compartment NA NA Human Human +DTXSID5024394 Css NA 0.03772 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024394 Css NA 0.2247 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024394 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID5024394 Css NA 0.1369 mg/L PBTK NA 95% Rat Human +DTXSID5024471 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024471 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024471 Vd NA 0.6916 L/kg 1compartment NA NA Human Human DTXSID5024471 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024471 TK.Half.Life NA 1.469 hours 1compartment NA NA Human Human -DTXSID5024471 Css NA 0.051 mg/L 3compartmentss NA 50% Human Human -DTXSID5024471 Css NA 0.3708 mg/L 3compartmentss NA 95% Human Human -DTXSID5024471 Css NA 0.03864 mg/L PBTK NA 50% Human Human -DTXSID5024471 Css NA 0.2624 mg/L PBTK NA 95% Human Human -DTXSID5024471 Clint NA 29.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024471 Fup NA 0.3363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024471 Vd NA 1.073 L/kg 1compartment NA NA Rat Human +DTXSID5024471 TK.Half.Life NA 1.749 hours 1compartment NA NA Human Human +DTXSID5024471 Css NA 0.2751 mg/L 3compartmentss NA 50% Human Human +DTXSID5024471 Css NA 2.138 mg/L 3compartmentss NA 95% Human Human +DTXSID5024471 Css NA 0.1744 mg/L PBTK NA 50% Human Human +DTXSID5024471 Css NA 1.304 mg/L PBTK NA 95% Human Human +DTXSID5024471 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024471 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024471 Vd NA 0.5643 L/kg 1compartment NA NA Rat Human DTXSID5024471 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024471 TK.Half.Life NA 0.5884 hours 1compartment NA NA Rat Human -DTXSID5024471 Css NA 0.02734 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024471 Css NA 0.1532 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024471 Css NA 0.02001 mg/L PBTK NA 50% Rat Human -DTXSID5024471 Css NA 0.1015 mg/L PBTK NA 95% Rat Human -DTXSID5024473 Clint NA 20.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024473 Fup NA 0.3892 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024473 Vd NA 1.349 L/kg 1compartment NA NA Human Human +DTXSID5024471 TK.Half.Life NA 0.8209 hours 1compartment NA NA Rat Human +DTXSID5024471 Css NA 0.03525 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024471 Css NA 0.223 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024471 Css NA 0.02172 mg/L PBTK NA 50% Rat Human +DTXSID5024471 Css NA 0.1315 mg/L PBTK NA 95% Rat Human +DTXSID5024473 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024473 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024473 Vd NA 1.135 L/kg 1compartment NA NA Human Human DTXSID5024473 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024473 TK.Half.Life NA 1.597 hours 1compartment NA NA Human Human -DTXSID5024473 Css NA 0.06028 mg/L 3compartmentss NA 50% Human Human -DTXSID5024473 Css NA 0.4695 mg/L 3compartmentss NA 95% Human Human -DTXSID5024473 Css NA 0.04752 mg/L PBTK NA 50% Human Human -DTXSID5024473 Css NA 0.3361 mg/L PBTK NA 95% Human Human -DTXSID5024473 Clint NA 20.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024473 Fup NA 0.3892 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024473 Vd NA 1.134 L/kg 1compartment NA NA Rat Human +DTXSID5024473 TK.Half.Life NA 1.557 hours 1compartment NA NA Human Human +DTXSID5024473 Css NA 0.07498 mg/L 3compartmentss NA 50% Human Human +DTXSID5024473 Css NA 0.5344 mg/L 3compartmentss NA 95% Human Human +DTXSID5024473 Css NA 0.05562 mg/L PBTK NA 50% Human Human +DTXSID5024473 Css NA 0.3668 mg/L PBTK NA 95% Human Human +DTXSID5024473 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024473 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024473 Vd NA 0.9498 L/kg 1compartment NA NA Rat Human DTXSID5024473 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024473 TK.Half.Life NA 0.6665 hours 1compartment NA NA Rat Human -DTXSID5024473 Css NA 0.03198 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024473 Css NA 0.185 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024473 Css NA 0.0245 mg/L PBTK NA 50% Rat Human -DTXSID5024473 Css NA 0.1261 mg/L PBTK NA 95% Rat Human -DTXSID5024479 Clint NA 0.1962 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024479 Fup NA 0.172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024479 Vd NA 0.2908 L/kg 1compartment NA NA Human Human -DTXSID5024479 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024479 TK.Half.Life NA 8.278 hours 1compartment NA NA Human Human -DTXSID5024479 Css NA 3.54 mg/L 3compartmentss NA 50% Human Human -DTXSID5024479 Css NA 12.83 mg/L 3compartmentss NA 95% Human Human -DTXSID5024479 Css NA 2.247 mg/L PBTK NA 50% Human Human -DTXSID5024479 Css NA 7.611 mg/L PBTK NA 95% Human Human -DTXSID5024479 Clint NA 0.1962 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024479 Fup NA 0.172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024479 Vd NA 0.2887 L/kg 1compartment NA NA Rat Human +DTXSID5024473 TK.Half.Life NA 0.6704 hours 1compartment NA NA Rat Human +DTXSID5024473 Css NA 0.009427 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024473 Css NA 0.05449 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024473 Css NA 0.006936 mg/L PBTK NA 50% Rat Human +DTXSID5024473 Css NA 0.03674 mg/L PBTK NA 95% Rat Human +DTXSID5024479 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024479 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024479 Vd NA 0.2717 L/kg 1compartment NA NA Human Human +DTXSID5024479 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5024479 TK.Half.Life NA 12.3 hours 1compartment NA NA Human Human +DTXSID5024479 Css NA 6.52 mg/L 3compartmentss NA 50% Human Human +DTXSID5024479 Css NA 28.09 mg/L 3compartmentss NA 95% Human Human +DTXSID5024479 Css NA 4.048 mg/L PBTK NA 50% Human Human +DTXSID5024479 Css NA 16.54 mg/L PBTK NA 95% Human Human +DTXSID5024479 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024479 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024479 Vd NA 0.2695 L/kg 1compartment NA NA Rat Human DTXSID5024479 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024479 TK.Half.Life NA 3.199 hours 1compartment NA NA Rat Human -DTXSID5024479 Css NA 1.174 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024479 Css NA 3.426 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024479 Css NA 0.6974 mg/L PBTK NA 50% Rat Human -DTXSID5024479 Css NA 1.916 mg/L PBTK NA 95% Rat Human +DTXSID5024479 TK.Half.Life NA 4.156 hours 1compartment NA NA Rat Human +DTXSID5024479 Css NA 0.427 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024479 Css NA 1.599 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024479 Css NA 0.2565 mg/L PBTK NA 50% Rat Human +DTXSID5024479 Css NA 0.9121 mg/L PBTK NA 95% Rat Human DTXSID5024500 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024500 Fup NA 0.5623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024500 Vd NA 0.3524 L/kg 1compartment NA NA Human Human +DTXSID5024500 Vd NA 0.435 L/kg 1compartment NA NA Human Human DTXSID5024500 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024500 TK.Half.Life NA 4.056 hours 1compartment NA NA Human Human -DTXSID5024500 Css NA 1.511 mg/L 3compartmentss NA 50% Human Human -DTXSID5024500 Css NA 9.214 mg/L 3compartmentss NA 95% Human Human -DTXSID5024500 Css NA 1.041 mg/L PBTK NA 50% Human Human -DTXSID5024500 Css NA 5.611 mg/L PBTK NA 95% Human Human +DTXSID5024500 TK.Half.Life NA 5.008 hours 1compartment NA NA Human Human +DTXSID5024500 Css NA 0.7756 mg/L 3compartmentss NA 50% Human Human +DTXSID5024500 Css NA 5.187 mg/L 3compartmentss NA 95% Human Human +DTXSID5024500 Css NA 0.5613 mg/L PBTK NA 50% Human Human +DTXSID5024500 Css NA 3.157 mg/L PBTK NA 95% Human Human DTXSID5024500 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024500 Fup NA 0.5623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024500 Vd NA 0.3738 L/kg 1compartment NA NA Rat Human +DTXSID5024500 Vd NA 0.4449 L/kg 1compartment NA NA Rat Human DTXSID5024500 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024500 TK.Half.Life NA 1.465 hours 1compartment NA NA Rat Human -DTXSID5024500 Css NA 0.3971 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024500 Css NA 2.342 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024500 Css NA 0.2609 mg/L PBTK NA 50% Rat Human -DTXSID5024500 Css NA 1.319 mg/L PBTK NA 95% Rat Human -DTXSID5024504 Clint NA 0.6562 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024504 Fup NA 0.211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024504 Vd NA 0.3652 L/kg 1compartment NA NA Human Human +DTXSID5024500 TK.Half.Life NA 1.745 hours 1compartment NA NA Rat Human +DTXSID5024500 Css NA 0.004139 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024500 Css NA 0.02829 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024500 Css NA 0.002854 mg/L PBTK NA 50% Rat Human +DTXSID5024500 Css NA 0.01645 mg/L PBTK NA 95% Rat Human +DTXSID5024504 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024504 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024504 Vd NA 0.5446 L/kg 1compartment NA NA Human Human DTXSID5024504 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024504 TK.Half.Life NA 5.382 hours 1compartment NA NA Human Human -DTXSID5024504 Css NA 1.77 mg/L 3compartmentss NA 50% Human Human -DTXSID5024504 Css NA 7.072 mg/L 3compartmentss NA 95% Human Human -DTXSID5024504 Css NA 1.172 mg/L PBTK NA 50% Human Human -DTXSID5024504 Css NA 4.349 mg/L PBTK NA 95% Human Human -DTXSID5024504 Clint NA 0.6562 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024504 Fup NA 0.211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024504 Vd NA 0.3685 L/kg 1compartment NA NA Rat Human +DTXSID5024504 TK.Half.Life NA 8.742 hours 1compartment NA NA Human Human +DTXSID5024504 Css NA 1.709 mg/L 3compartmentss NA 50% Human Human +DTXSID5024504 Css NA 7.445 mg/L 3compartmentss NA 95% Human Human +DTXSID5024504 Css NA 1.288 mg/L PBTK NA 50% Human Human +DTXSID5024504 Css NA 4.802 mg/L PBTK NA 95% Human Human +DTXSID5024504 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024504 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024504 Vd NA 0.5499 L/kg 1compartment NA NA Rat Human DTXSID5024504 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024504 TK.Half.Life NA 2.517 hours 1compartment NA NA Rat Human -DTXSID5024504 Css NA 0.6806 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024504 Css NA 2.172 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024504 Css NA 0.4282 mg/L PBTK NA 50% Rat Human -DTXSID5024504 Css NA 1.247 mg/L PBTK NA 95% Rat Human -DTXSID5024506 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5024504 TK.Half.Life NA 3.008 hours 1compartment NA NA Rat Human +DTXSID5024504 Css NA 0.1089 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024504 Css NA 0.424 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024504 Css NA 0.08133 mg/L PBTK NA 50% Rat Human +DTXSID5024504 Css NA 0.2621 mg/L PBTK NA 95% Rat Human +DTXSID5024506 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5024506 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5024506 Vd NA 0.3896 L/kg 1compartment NA NA Human Human DTXSID5024506 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5024506 TK.Half.Life NA 6.466 hours 1compartment NA NA Human Human -DTXSID5024506 Css NA 1.976 mg/L 3compartmentss NA 50% Human Human -DTXSID5024506 Css NA 8.154 mg/L 3compartmentss NA 95% Human Human -DTXSID5024506 Css NA 1.37 mg/L PBTK NA 50% Human Human -DTXSID5024506 Css NA 5.083 mg/L PBTK NA 95% Human Human -DTXSID5024506 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5024506 Css NA 1.154 mg/L 3compartmentss NA 50% Human Human +DTXSID5024506 Css NA 5.214 mg/L 3compartmentss NA 95% Human Human +DTXSID5024506 Css NA 0.8034 mg/L PBTK NA 50% Human Human +DTXSID5024506 Css NA 3.246 mg/L PBTK NA 95% Human Human +DTXSID5024506 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5024506 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5024506 Vd NA 0.3932 L/kg 1compartment NA NA Rat Human DTXSID5024506 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5024506 TK.Half.Life NA 2.223 hours 1compartment NA NA Rat Human -DTXSID5024506 Css NA 0.5488 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024506 Css NA 1.911 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024506 Css NA 0.3603 mg/L PBTK NA 50% Rat Human -DTXSID5024506 Css NA 1.104 mg/L PBTK NA 95% Rat Human +DTXSID5024506 Css NA 0.006864 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024506 Css NA 0.03379 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024506 Css NA 0.004547 mg/L PBTK NA 50% Rat Human +DTXSID5024506 Css NA 0.02048 mg/L PBTK NA 95% Rat Human DTXSID5024508 Clint NA 5.851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024508 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024508 Vd NA 1.083 L/kg 1compartment NA NA Human Human DTXSID5024508 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5024508 TK.Half.Life NA 1.129 hours 1compartment NA NA Human Human -DTXSID5024508 Css NA 0.07654 mg/L 3compartmentss NA 50% Human Human -DTXSID5024508 Css NA 0.7091 mg/L 3compartmentss NA 95% Human Human -DTXSID5024508 Css NA 0.06812 mg/L PBTK NA 50% Human Human -DTXSID5024508 Css NA 0.5417 mg/L PBTK NA 95% Human Human +DTXSID5024508 Css NA 0.06076 mg/L 3compartmentss NA 50% Human Human +DTXSID5024508 Css NA 0.6104 mg/L 3compartmentss NA 95% Human Human +DTXSID5024508 Css NA 0.05366 mg/L PBTK NA 50% Human Human +DTXSID5024508 Css NA 0.4485 mg/L PBTK NA 95% Human Human DTXSID5024508 Clint NA 5.851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024508 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024508 Vd NA 1.074 L/kg 1compartment NA NA Rat Human DTXSID5024508 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5024508 TK.Half.Life NA 0.5805 hours 1compartment NA NA Rat Human -DTXSID5024508 Css NA 0.03562 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024508 Css NA 0.2696 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024508 Css NA 0.0316 mg/L PBTK NA 50% Rat Human -DTXSID5024508 Css NA 0.1813 mg/L PBTK NA 95% Rat Human -DTXSID5024554 Clint NA 250.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024554 Fup NA 0.06 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024554 Vd NA 1.63 L/kg 1compartment NA NA Human Human +DTXSID5024508 Css NA 0.001992 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024508 Css NA 0.02219 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024508 Css NA 0.001762 mg/L PBTK NA 50% Rat Human +DTXSID5024508 Css NA 0.01652 mg/L PBTK NA 95% Rat Human +DTXSID5024554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024554 Fup 0.0638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024554 Vd NA 1.861 L/kg 1compartment NA NA Human Human DTXSID5024554 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024554 TK.Half.Life NA 1.891 hours 1compartment NA NA Human Human -DTXSID5024554 Css NA 0.04978 mg/L 3compartmentss NA 50% Human Human -DTXSID5024554 Css NA 0.385 mg/L 3compartmentss NA 95% Human Human -DTXSID5024554 Css NA 0.03219 mg/L PBTK NA 50% Human Human -DTXSID5024554 Css NA 0.2406 mg/L PBTK NA 95% Human Human -DTXSID5024554 Clint NA 250.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024554 Fup NA 0.06 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024554 Vd NA 1.228 L/kg 1compartment NA NA Rat Human +DTXSID5024554 TK.Half.Life NA 8.072 hours 1compartment NA NA Human Human +DTXSID5024554 Css NA 0.5317 mg/L 3compartmentss NA 50% Human Human +DTXSID5024554 Css NA 3.743 mg/L 3compartmentss NA 95% Human Human +DTXSID5024554 Css NA 0.3484 mg/L PBTK NA 50% Human Human +DTXSID5024554 Css NA 2.365 mg/L PBTK NA 95% Human Human +DTXSID5024554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024554 Fup 0.0638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024554 Vd NA 1.4 L/kg 1compartment NA NA Rat Human DTXSID5024554 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024554 TK.Half.Life NA 0.6521 hours 1compartment NA NA Rat Human -DTXSID5024554 Css NA 0.02801 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024554 Css NA 0.1852 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024554 Css NA 0.01715 mg/L PBTK NA 50% Rat Human -DTXSID5024554 Css NA 0.1087 mg/L PBTK NA 95% Rat Human +DTXSID5024554 TK.Half.Life NA 2.786 hours 1compartment NA NA Rat Human +DTXSID5024554 Css NA 0.06972 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024554 Css NA 0.3877 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024554 Css NA 0.04486 mg/L PBTK NA 50% Rat Human +DTXSID5024554 Css NA 0.2408 mg/L PBTK NA 95% Rat Human DTXSID5024681 Clint NA 9.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024681 Fup NA 0.7781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024681 Vd NA 1.668 L/kg 1compartment NA NA Human Human DTXSID5024681 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5024681 TK.Half.Life NA 1.588 hours 1compartment NA NA Human Human -DTXSID5024681 Css NA 0.05722 mg/L 3compartmentss NA 50% Human Human -DTXSID5024681 Css NA 0.5503 mg/L 3compartmentss NA 95% Human Human -DTXSID5024681 Css NA 0.05452 mg/L PBTK NA 50% Human Human -DTXSID5024681 Css NA 0.4081 mg/L PBTK NA 95% Human Human +DTXSID5024681 Css NA 0.04542 mg/L 3compartmentss NA 50% Human Human +DTXSID5024681 Css NA 0.4423 mg/L 3compartmentss NA 95% Human Human +DTXSID5024681 Css NA 0.0429 mg/L PBTK NA 50% Human Human +DTXSID5024681 Css NA 0.3324 mg/L PBTK NA 95% Human Human DTXSID5024681 Clint NA 9.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024681 Fup NA 0.7781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024681 Vd NA 1.656 L/kg 1compartment NA NA Rat Human DTXSID5024681 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5024681 TK.Half.Life NA 0.8366 hours 1compartment NA NA Rat Human -DTXSID5024681 Css NA 0.02712 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024681 Css NA 0.2405 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024681 Css NA 0.02622 mg/L PBTK NA 50% Rat Human -DTXSID5024681 Css NA 0.1587 mg/L PBTK NA 95% Rat Human -DTXSID5024683 Clint NA 36.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024683 Fup NA 0.102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024683 Vd NA 1.572 L/kg 1compartment NA NA Human Human -DTXSID5024683 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024683 TK.Half.Life NA 3.219 hours 1compartment NA NA Human Human -DTXSID5024683 Css NA 0.1929 mg/L 3compartmentss NA 50% Human Human -DTXSID5024683 Css NA 1.446 mg/L 3compartmentss NA 95% Human Human -DTXSID5024683 Css NA 0.1279 mg/L PBTK NA 50% Human Human -DTXSID5024683 Css NA 0.9231 mg/L PBTK NA 95% Human Human -DTXSID5024683 Clint NA 36.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024683 Fup NA 0.102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024683 Vd NA 1.202 L/kg 1compartment NA NA Rat Human +DTXSID5024681 Css NA 0.001555 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024681 Css NA 0.0179 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024681 Css NA 0.001505 mg/L PBTK NA 50% Rat Human +DTXSID5024681 Css NA 0.01336 mg/L PBTK NA 95% Rat Human +DTXSID5024683 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024683 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024683 Vd NA 2.778 L/kg 1compartment NA NA Human Human +DTXSID5024683 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5024683 TK.Half.Life NA 14.68 hours 1compartment NA NA Human Human +DTXSID5024683 Css NA 0.5743 mg/L 3compartmentss NA 50% Human Human +DTXSID5024683 Css NA 3.679 mg/L 3compartmentss NA 95% Human Human +DTXSID5024683 Css NA 0.4006 mg/L PBTK NA 50% Human Human +DTXSID5024683 Css NA 2.449 mg/L PBTK NA 95% Human Human +DTXSID5024683 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024683 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024683 Vd NA 2.092 L/kg 1compartment NA NA Rat Human DTXSID5024683 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024683 TK.Half.Life NA 1.208 hours 1compartment NA NA Rat Human -DTXSID5024683 Css NA 0.107 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024683 Css NA 0.654 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024683 Css NA 0.06751 mg/L PBTK NA 50% Rat Human -DTXSID5024683 Css NA 0.3909 mg/L PBTK NA 95% Rat Human -DTXSID5024687 Clint NA 3.329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024687 Fup NA 0.1906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024687 Vd NA 2.27 L/kg 1compartment NA NA Human Human -DTXSID5024687 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5024687 TK.Half.Life NA 23.12 hours 1compartment NA NA Human Human -DTXSID5024687 Css NA 1.172 mg/L 3compartmentss NA 50% Human Human -DTXSID5024687 Css NA 5.291 mg/L 3compartmentss NA 95% Human Human -DTXSID5024687 Css NA 0.844 mg/L PBTK NA 50% Human Human -DTXSID5024687 Css NA 3.629 mg/L PBTK NA 95% Human Human -DTXSID5024687 Clint NA 3.329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024687 Fup NA 0.1906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024687 Vd NA 1.736 L/kg 1compartment NA NA Rat Human -DTXSID5024687 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5024687 TK.Half.Life NA 6.319 hours 1compartment NA NA Rat Human -DTXSID5024687 Css NA 0.57 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024687 Css NA 1.853 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024687 Css NA 0.3952 mg/L PBTK NA 50% Rat Human -DTXSID5024687 Css NA 1.169 mg/L PBTK NA 95% Rat Human +DTXSID5024683 TK.Half.Life NA 3.191 hours 1compartment NA NA Rat Human +DTXSID5024683 Css NA 0.07413 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024683 Css NA 0.3925 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024683 Css NA 0.05123 mg/L PBTK NA 50% Rat Human +DTXSID5024683 Css NA 0.2611 mg/L PBTK NA 95% Rat Human +DTXSID5024687 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024687 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024687 Vd NA 1.801 L/kg 1compartment NA NA Human Human +DTXSID5024687 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5024687 TK.Half.Life NA 5.001 hours 1compartment NA NA Human Human +DTXSID5024687 Css NA 0.2854 mg/L 3compartmentss NA 50% Human Human +DTXSID5024687 Css NA 2.106 mg/L 3compartmentss NA 95% Human Human +DTXSID5024687 Css NA 0.1932 mg/L PBTK NA 50% Human Human +DTXSID5024687 Css NA 1.346 mg/L PBTK NA 95% Human Human +DTXSID5024687 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024687 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024687 Vd NA 1.374 L/kg 1compartment NA NA Rat Human +DTXSID5024687 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5024687 TK.Half.Life NA 1.785 hours 1compartment NA NA Rat Human +DTXSID5024687 Css NA 0.03661 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024687 Css NA 0.2138 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024687 Css NA 0.02437 mg/L PBTK NA 50% Rat Human +DTXSID5024687 Css NA 0.1349 mg/L PBTK NA 95% Rat Human DTXSID5024710 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024710 Fup NA 0.8574 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024710 Vd NA 1.031 L/kg 1compartment NA NA Human Human +DTXSID5024710 Vd NA 1.111 L/kg 1compartment NA NA Human Human DTXSID5024710 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024710 TK.Half.Life NA 7.961 hours 1compartment NA NA Human Human -DTXSID5024710 Css NA 0.9088 mg/L 3compartmentss NA 50% Human Human -DTXSID5024710 Css NA 5.592 mg/L 3compartmentss NA 95% Human Human -DTXSID5024710 Css NA 0.7986 mg/L PBTK NA 50% Human Human -DTXSID5024710 Css NA 3.714 mg/L PBTK NA 95% Human Human +DTXSID5024710 TK.Half.Life NA 8.68 hours 1compartment NA NA Human Human +DTXSID5024710 Css NA 0.756 mg/L 3compartmentss NA 50% Human Human +DTXSID5024710 Css NA 4.73 mg/L 3compartmentss NA 95% Human Human +DTXSID5024710 Css NA 0.6746 mg/L PBTK NA 50% Human Human +DTXSID5024710 Css NA 3.187 mg/L PBTK NA 95% Human Human DTXSID5024710 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024710 Fup NA 0.8574 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024710 Vd NA 1.007 L/kg 1compartment NA NA Rat Human +DTXSID5024710 Vd NA 1.067 L/kg 1compartment NA NA Rat Human DTXSID5024710 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024710 TK.Half.Life NA 2.604 hours 1compartment NA NA Rat Human -DTXSID5024710 Css NA 0.2304 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024710 Css NA 1.404 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024710 Css NA 0.1975 mg/L PBTK NA 50% Rat Human -DTXSID5024710 Css NA 0.8606 mg/L PBTK NA 95% Rat Human -DTXSID5024764 Clint NA 7.648 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024764 Fup NA 0.4011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024764 Vd NA 1.999 L/kg 1compartment NA NA Human Human +DTXSID5024710 TK.Half.Life NA 2.767 hours 1compartment NA NA Rat Human +DTXSID5024710 Css NA 0.0139 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024710 Css NA 0.1128 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024710 Css NA 0.01202 mg/L PBTK NA 50% Rat Human +DTXSID5024710 Css NA 0.07556 mg/L PBTK NA 95% Rat Human +DTXSID5024764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024764 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024764 Vd NA 1.266 L/kg 1compartment NA NA Human Human DTXSID5024764 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024764 TK.Half.Life NA 4.661 hours 1compartment NA NA Human Human -DTXSID5024764 Css NA 0.1933 mg/L 3compartmentss NA 50% Human Human -DTXSID5024764 Css NA 1.168 mg/L 3compartmentss NA 95% Human Human -DTXSID5024764 Css NA 0.1552 mg/L PBTK NA 50% Human Human -DTXSID5024764 Css NA 0.8458 mg/L PBTK NA 95% Human Human -DTXSID5024764 Clint NA 7.648 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024764 Fup NA 0.4011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024764 Vd NA 1.592 L/kg 1compartment NA NA Rat Human +DTXSID5024764 TK.Half.Life NA 2.651 hours 1compartment NA NA Human Human +DTXSID5024764 Css NA 0.1838 mg/L 3compartmentss NA 50% Human Human +DTXSID5024764 Css NA 1.423 mg/L 3compartmentss NA 95% Human Human +DTXSID5024764 Css NA 0.1243 mg/L PBTK NA 50% Human Human +DTXSID5024764 Css NA 0.902 mg/L PBTK NA 95% Human Human +DTXSID5024764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024764 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024764 Vd NA 0.9968 L/kg 1compartment NA NA Rat Human DTXSID5024764 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024764 TK.Half.Life NA 1.639 hours 1compartment NA NA Rat Human -DTXSID5024764 Css NA 0.0996 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024764 Css NA 0.4524 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024764 Css NA 0.07707 mg/L PBTK NA 50% Rat Human -DTXSID5024764 Css NA 0.3083 mg/L PBTK NA 95% Rat Human +DTXSID5024764 TK.Half.Life NA 1.092 hours 1compartment NA NA Rat Human +DTXSID5024764 Css NA 0.02373 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024764 Css NA 0.1422 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024764 Css NA 0.01587 mg/L PBTK NA 50% Rat Human +DTXSID5024764 Css NA 0.08838 mg/L PBTK NA 95% Rat Human DTXSID5024845 Clint 0.698 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID5024845 Fup 0.61 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5024845 Vd NA 2.033 L/kg 1compartment NA NA Human Human DTXSID5024845 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5024845 TK.Half.Life NA 10.76 hours 1compartment NA NA Human Human -DTXSID5024845 Css NA 0.4716 mg/L 3compartmentss NA 50% Human Human -DTXSID5024845 Css NA 3.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5024845 Css NA 0.4672 mg/L PBTK NA 50% Human Human -DTXSID5024845 Css NA 2.608 mg/L PBTK NA 95% Human Human +DTXSID5024845 Css NA 0.4586 mg/L 3compartmentss NA 50% Human Human +DTXSID5024845 Css NA 3.476 mg/L 3compartmentss NA 95% Human Human +DTXSID5024845 Css NA 0.4536 mg/L PBTK NA 50% Human Human +DTXSID5024845 Css NA 2.405 mg/L PBTK NA 95% Human Human DTXSID5024845 Clint 0.698 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID5024845 Fup 0.61 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5024845 Vd NA 1.993 L/kg 1compartment NA NA Rat Human DTXSID5024845 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5024845 TK.Half.Life NA 4.706 hours 1compartment NA NA Rat Human -DTXSID5024845 Css NA 0.1729 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024845 Css NA 1.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024845 Css NA 0.1668 mg/L PBTK NA 50% Rat Human -DTXSID5024845 Css NA 0.8228 mg/L PBTK NA 95% Rat Human +DTXSID5024845 Css NA 0.03774 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024845 Css NA 0.3019 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024845 Css NA 0.03796 mg/L PBTK NA 50% Rat Human +DTXSID5024845 Css NA 0.1953 mg/L PBTK NA 95% Rat Human DTXSID5024891 Clint 16.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5024891 Fup 0.96 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5024891 Vd NA 0.922 L/kg 1compartment NA NA Human Human +DTXSID5024891 Vd NA 0.9615 L/kg 1compartment NA NA Human Human DTXSID5024891 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024891 TK.Half.Life NA 0.6809 hours 1compartment NA NA Human Human -DTXSID5024891 Css NA 0.02627 mg/L 3compartmentss NA 50% Human Human -DTXSID5024891 Css NA 0.1666 mg/L 3compartmentss NA 95% Human Human -DTXSID5024891 Css NA 0.02246 mg/L PBTK NA 50% Human Human -DTXSID5024891 Css NA 0.1323 mg/L PBTK NA 95% Human Human +DTXSID5024891 TK.Half.Life NA 0.7106 hours 1compartment NA NA Human Human +DTXSID5024891 Css NA 0.009288 mg/L 3compartmentss NA 50% Human Human +DTXSID5024891 Css NA 0.08899 mg/L 3compartmentss NA 95% Human Human +DTXSID5024891 Css NA 0.007914 mg/L PBTK NA 50% Human Human +DTXSID5024891 Css NA 0.07039 mg/L PBTK NA 95% Human Human DTXSID5024891 Clint 16.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5024891 Fup 0.96 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5024891 Vd NA 0.9711 L/kg 1compartment NA NA Rat Human +DTXSID5024891 Vd NA 1.007 L/kg 1compartment NA NA Rat Human DTXSID5024891 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024891 TK.Half.Life NA 0.348 hours 1compartment NA NA Rat Human -DTXSID5024891 Css NA 0.01354 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024891 Css NA 0.06287 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024891 Css NA 0.0114 mg/L PBTK NA 50% Rat Human -DTXSID5024891 Css NA 0.04972 mg/L PBTK NA 95% Rat Human +DTXSID5024891 TK.Half.Life NA 0.362 hours 1compartment NA NA Rat Human +DTXSID5024891 Css NA 7.435e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024891 Css NA 0.0006705 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024891 Css NA 6.33e-05 mg/L PBTK NA 50% Rat Human +DTXSID5024891 Css NA 0.0005328 mg/L PBTK NA 95% Rat Human DTXSID5024922 Clint NA 10.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5024922 Fup NA 0.8167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024922 Vd NA 1.534 L/kg 1compartment NA NA Human Human +DTXSID5024922 Vd NA 1.498 L/kg 1compartment NA NA Human Human DTXSID5024922 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024922 TK.Half.Life NA 1.355 hours 1compartment NA NA Human Human -DTXSID5024922 Css NA 0.04963 mg/L 3compartmentss NA 50% Human Human -DTXSID5024922 Css NA 0.4836 mg/L 3compartmentss NA 95% Human Human -DTXSID5024922 Css NA 0.04623 mg/L PBTK NA 50% Human Human -DTXSID5024922 Css NA 0.3664 mg/L PBTK NA 95% Human Human +DTXSID5024922 TK.Half.Life NA 1.328 hours 1compartment NA NA Human Human +DTXSID5024922 Css NA 0.03997 mg/L 3compartmentss NA 50% Human Human +DTXSID5024922 Css NA 0.4005 mg/L 3compartmentss NA 95% Human Human +DTXSID5024922 Css NA 0.03721 mg/L PBTK NA 50% Human Human +DTXSID5024922 Css NA 0.3066 mg/L PBTK NA 95% Human Human DTXSID5024922 Clint NA 10.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5024922 Fup NA 0.8167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024922 Vd NA 1.524 L/kg 1compartment NA NA Rat Human +DTXSID5024922 Vd NA 1.489 L/kg 1compartment NA NA Rat Human DTXSID5024922 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024922 TK.Half.Life NA 0.7014 hours 1compartment NA NA Rat Human -DTXSID5024922 Css NA 0.0245 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024922 Css NA 0.1968 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024922 Css NA 0.02288 mg/L PBTK NA 50% Rat Human -DTXSID5024922 Css NA 0.1337 mg/L PBTK NA 95% Rat Human -DTXSID5024926 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024926 Fup NA 0.2371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024926 Vd NA 0.2762 L/kg 1compartment NA NA Human Human +DTXSID5024922 TK.Half.Life NA 0.6876 hours 1compartment NA NA Rat Human +DTXSID5024922 Css NA 0.00134 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024922 Css NA 0.01729 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024922 Css NA 0.001232 mg/L PBTK NA 50% Rat Human +DTXSID5024922 Css NA 0.01258 mg/L PBTK NA 95% Rat Human +DTXSID5024926 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024926 Fup 0.0973 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024926 Vd NA 0.2411 L/kg 1compartment NA NA Human Human DTXSID5024926 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5024926 TK.Half.Life NA 7.537 hours 1compartment NA NA Human Human -DTXSID5024926 Css NA 3.487 mg/L 3compartmentss NA 50% Human Human -DTXSID5024926 Css NA 12.92 mg/L 3compartmentss NA 95% Human Human -DTXSID5024926 Css NA 2.234 mg/L PBTK NA 50% Human Human -DTXSID5024926 Css NA 7.717 mg/L PBTK NA 95% Human Human -DTXSID5024926 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024926 Fup NA 0.2371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024926 Vd NA 0.2878 L/kg 1compartment NA NA Rat Human +DTXSID5024926 TK.Half.Life NA 1.018 hours 1compartment NA NA Human Human +DTXSID5024926 Css NA 0.3064 mg/L 3compartmentss NA 50% Human Human +DTXSID5024926 Css NA 2.454 mg/L 3compartmentss NA 95% Human Human +DTXSID5024926 Css NA 0.1861 mg/L PBTK NA 50% Human Human +DTXSID5024926 Css NA 1.452 mg/L PBTK NA 95% Human Human +DTXSID5024926 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024926 Fup 0.0973 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024926 Vd NA 0.2486 L/kg 1compartment NA NA Rat Human DTXSID5024926 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5024926 TK.Half.Life NA 2.676 hours 1compartment NA NA Rat Human -DTXSID5024926 Css NA 0.9709 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024926 Css NA 2.909 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024926 Css NA 0.5867 mg/L PBTK NA 50% Rat Human -DTXSID5024926 Css NA 1.638 mg/L PBTK NA 95% Rat Human -DTXSID5024976 Clint NA 0.5855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024976 Fup NA 0.031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024976 Vd NA 0.2745 L/kg 1compartment NA NA Human Human -DTXSID5024976 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5024976 TK.Half.Life NA 29.16 hours 1compartment NA NA Human Human -DTXSID5024976 Css NA 17.74 mg/L 3compartmentss NA 50% Human Human -DTXSID5024976 Css NA 113.3 mg/L 3compartmentss NA 95% Human Human -DTXSID5024976 Css NA 10.76 mg/L PBTK NA 50% Human Human -DTXSID5024976 Css NA 65.38 mg/L PBTK NA 95% Human Human -DTXSID5024976 Clint NA 0.5855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024976 Fup NA 0.031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024976 Vd NA 0.2678 L/kg 1compartment NA NA Rat Human -DTXSID5024976 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5024976 TK.Half.Life NA 12.96 hours 1compartment NA NA Rat Human -DTXSID5024976 Css NA 6.928 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024976 Css NA 37.03 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024976 Css NA 3.904 mg/L PBTK NA 50% Rat Human -DTXSID5024976 Css NA 20.15 mg/L PBTK NA 95% Rat Human -DTXSID5024978 Clint NA 0.9149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024978 Fup NA 0.029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5024978 Vd NA 0.2599 L/kg 1compartment NA NA Human Human -DTXSID5024978 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5024978 TK.Half.Life NA 23.15 hours 1compartment NA NA Human Human -DTXSID5024978 Css NA 15.38 mg/L 3compartmentss NA 50% Human Human -DTXSID5024978 Css NA 104 mg/L 3compartmentss NA 95% Human Human -DTXSID5024978 Css NA 9.326 mg/L PBTK NA 50% Human Human -DTXSID5024978 Css NA 59.65 mg/L PBTK NA 95% Human Human -DTXSID5024978 Clint NA 0.9149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024978 Fup NA 0.029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5024978 Vd NA 0.2536 L/kg 1compartment NA NA Rat Human -DTXSID5024978 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5024978 TK.Half.Life NA 11.13 hours 1compartment NA NA Rat Human -DTXSID5024978 Css NA 6.366 mg/L 3compartmentss NA 50% Rat Human -DTXSID5024978 Css NA 35.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID5024978 Css NA 3.581 mg/L PBTK NA 50% Rat Human -DTXSID5024978 Css NA 19.06 mg/L PBTK NA 95% Rat Human -DTXSID5025021 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025021 Fup NA 0.0155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025021 Vd NA 3.111 L/kg 1compartment NA NA Human Human -DTXSID5025021 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5025021 TK.Half.Life NA 34.23 hours 1compartment NA NA Human Human -DTXSID5025021 Css NA 1.27 mg/L 3compartmentss NA 50% Human Human -DTXSID5025021 Css NA 7.376 mg/L 3compartmentss NA 95% Human Human -DTXSID5025021 Css NA 0.8856 mg/L PBTK NA 50% Human Human -DTXSID5025021 Css NA 4.967 mg/L PBTK NA 95% Human Human -DTXSID5025021 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025021 Fup NA 0.0155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025021 Vd NA 2.331 L/kg 1compartment NA NA Rat Human -DTXSID5025021 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5025021 TK.Half.Life NA 4.972 hours 1compartment NA NA Rat Human -DTXSID5025021 Css NA 0.7189 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025021 Css NA 3.215 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025021 Css NA 0.4755 mg/L PBTK NA 50% Rat Human -DTXSID5025021 Css NA 2.119 mg/L PBTK NA 95% Rat Human -DTXSID5025071 Clint NA 1.629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025071 Fup NA 0.1108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025071 Vd NA 2.65 L/kg 1compartment NA NA Human Human -DTXSID5025071 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID5025071 TK.Half.Life NA 116.5 hours 1compartment NA NA Human Human -DTXSID5025071 Css NA 5.724 mg/L 3compartmentss NA 50% Human Human -DTXSID5025071 Css NA 23.82 mg/L 3compartmentss NA 95% Human Human -DTXSID5025071 Css NA 3.978 mg/L PBTK NA 50% Human Human -DTXSID5025071 Css NA 15.57 mg/L PBTK NA 95% Human Human -DTXSID5025071 Clint NA 1.629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025071 Fup NA 0.1108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025071 Vd NA 1.997 L/kg 1compartment NA NA Rat Human -DTXSID5025071 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID5025071 TK.Half.Life NA 22.24 hours 1compartment NA NA Rat Human -DTXSID5025071 Css NA 2.674 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025071 Css NA 7.996 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025071 Css NA 1.782 mg/L PBTK NA 50% Rat Human -DTXSID5025071 Css NA 4.84 mg/L PBTK NA 95% Rat Human -DTXSID5025100 Clint NA 0.7867 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025100 Fup NA 0.7906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025100 Vd NA 1.952 L/kg 1compartment NA NA Human Human -DTXSID5025100 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025100 TK.Half.Life NA 7.259 hours 1compartment NA NA Human Human -DTXSID5025100 Css NA 0.363 mg/L 3compartmentss NA 50% Human Human -DTXSID5025100 Css NA 2.636 mg/L 3compartmentss NA 95% Human Human -DTXSID5025100 Css NA 0.3617 mg/L PBTK NA 50% Human Human -DTXSID5025100 Css NA 1.841 mg/L PBTK NA 95% Human Human -DTXSID5025100 Clint NA 0.7867 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025100 Fup NA 0.7906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025100 Vd NA 1.981 L/kg 1compartment NA NA Rat Human +DTXSID5024926 TK.Half.Life NA 0.643 hours 1compartment NA NA Rat Human +DTXSID5024926 Css NA 0.003203 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024926 Css NA 0.02273 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024926 Css NA 0.001822 mg/L PBTK NA 50% Rat Human +DTXSID5024926 Css NA 0.01264 mg/L PBTK NA 95% Rat Human +DTXSID5024970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024970 Fup 0.0877 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024970 Vd NA 1.252 L/kg 1compartment NA NA Human Human +DTXSID5024970 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5024970 TK.Half.Life NA 3.729 hours 1compartment NA NA Human Human +DTXSID5024970 Css NA 0.3365 mg/L 3compartmentss NA 50% Human Human +DTXSID5024970 Css NA 2.573 mg/L 3compartmentss NA 95% Human Human +DTXSID5024970 Css NA 0.2182 mg/L PBTK NA 50% Human Human +DTXSID5024970 Css NA 1.582 mg/L PBTK NA 95% Human Human +DTXSID5024970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024970 Fup 0.0877 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024970 Vd NA 0.963 L/kg 1compartment NA NA Rat Human +DTXSID5024970 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5024970 TK.Half.Life NA 1.537 hours 1compartment NA NA Rat Human +DTXSID5024970 Css NA 0.04398 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024970 Css NA 0.2621 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024970 Css NA 0.02794 mg/L PBTK NA 50% Rat Human +DTXSID5024970 Css NA 0.1604 mg/L PBTK NA 95% Rat Human +DTXSID5024976 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024976 Fup 0.0748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024976 Vd NA 0.4068 L/kg 1compartment NA NA Human Human +DTXSID5024976 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5024976 TK.Half.Life NA 1.288 hours 1compartment NA NA Human Human +DTXSID5024976 Css NA 0.3837 mg/L 3compartmentss NA 50% Human Human +DTXSID5024976 Css NA 3.028 mg/L 3compartmentss NA 95% Human Human +DTXSID5024976 Css NA 0.2462 mg/L PBTK NA 50% Human Human +DTXSID5024976 Css NA 1.849 mg/L PBTK NA 95% Human Human +DTXSID5024976 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024976 Fup 0.0748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024976 Vd NA 0.3985 L/kg 1compartment NA NA Rat Human +DTXSID5024976 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5024976 TK.Half.Life NA 0.7727 hours 1compartment NA NA Rat Human +DTXSID5024976 Css NA 0.05026 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024976 Css NA 0.3026 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024976 Css NA 0.0313 mg/L PBTK NA 50% Rat Human +DTXSID5024976 Css NA 0.1792 mg/L PBTK NA 95% Rat Human +DTXSID5024978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024978 Fup 0.0746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5024978 Vd NA 0.3798 L/kg 1compartment NA NA Human Human +DTXSID5024978 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5024978 TK.Half.Life NA 1.209 hours 1compartment NA NA Human Human +DTXSID5024978 Css NA 0.3882 mg/L 3compartmentss NA 50% Human Human +DTXSID5024978 Css NA 3.045 mg/L 3compartmentss NA 95% Human Human +DTXSID5024978 Css NA 0.247 mg/L PBTK NA 50% Human Human +DTXSID5024978 Css NA 1.855 mg/L PBTK NA 95% Human Human +DTXSID5024978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024978 Fup 0.0746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5024978 Vd NA 0.372 L/kg 1compartment NA NA Rat Human +DTXSID5024978 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5024978 TK.Half.Life NA 0.7245 hours 1compartment NA NA Rat Human +DTXSID5024978 Css NA 0.05084 mg/L 3compartmentss NA 50% Rat Human +DTXSID5024978 Css NA 0.305 mg/L 3compartmentss NA 95% Rat Human +DTXSID5024978 Css NA 0.0314 mg/L PBTK NA 50% Rat Human +DTXSID5024978 Css NA 0.1798 mg/L PBTK NA 95% Rat Human +DTXSID5025021 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025021 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025021 Vd NA 2.999 L/kg 1compartment NA NA Human Human +DTXSID5025021 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID5025021 TK.Half.Life NA 71.22 hours 1compartment NA NA Human Human +DTXSID5025021 Css NA 2.948 mg/L 3compartmentss NA 50% Human Human +DTXSID5025021 Css NA 20.3 mg/L 3compartmentss NA 95% Human Human +DTXSID5025021 Css NA 2.032 mg/L PBTK NA 50% Human Human +DTXSID5025021 Css NA 13.2 mg/L PBTK NA 95% Human Human +DTXSID5025021 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025021 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025021 Vd NA 2.244 L/kg 1compartment NA NA Rat Human +DTXSID5025021 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID5025021 TK.Half.Life NA 11.25 hours 1compartment NA NA Rat Human +DTXSID5025021 Css NA 0.3858 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025021 Css NA 2.287 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025021 Css NA 0.2601 mg/L PBTK NA 50% Rat Human +DTXSID5025021 Css NA 1.517 mg/L PBTK NA 95% Rat Human +DTXSID5025079 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025079 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025079 Vd NA 2.992 L/kg 1compartment NA NA Human Human +DTXSID5025079 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5025079 TK.Half.Life NA 2.203 hours 1compartment NA NA Human Human +DTXSID5025079 Css NA 0.02268 mg/L 3compartmentss NA 50% Human Human +DTXSID5025079 Css NA 0.2434 mg/L 3compartmentss NA 95% Human Human +DTXSID5025079 Css NA 0.02852 mg/L PBTK NA 50% Human Human +DTXSID5025079 Css NA 0.2201 mg/L PBTK NA 95% Human Human +DTXSID5025079 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025079 Fup 0.447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025079 Vd NA 2.969 L/kg 1compartment NA NA Rat Human +DTXSID5025079 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5025079 TK.Half.Life NA 1.177 hours 1compartment NA NA Rat Human +DTXSID5025079 Css NA 0.002728 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025079 Css NA 0.02329 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025079 Css NA 0.00353 mg/L PBTK NA 50% Rat Human +DTXSID5025079 Css NA 0.0212 mg/L PBTK NA 95% Rat Human +DTXSID5025100 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025100 Fup 0.857 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025100 Vd NA 2.611 L/kg 1compartment NA NA Human Human +DTXSID5025100 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5025100 TK.Half.Life NA 19.9 hours 1compartment NA NA Human Human +DTXSID5025100 Css NA 0.6968 mg/L 3compartmentss NA 50% Human Human +DTXSID5025100 Css NA 5.003 mg/L 3compartmentss NA 95% Human Human +DTXSID5025100 Css NA 0.7642 mg/L PBTK NA 50% Human Human +DTXSID5025100 Css NA 3.638 mg/L PBTK NA 95% Human Human +DTXSID5025100 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025100 Fup 0.857 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025100 Vd NA 2.651 L/kg 1compartment NA NA Rat Human DTXSID5025100 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025100 TK.Half.Life NA 3.45 hours 1compartment NA NA Rat Human -DTXSID5025100 Css NA 0.1285 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025100 Css NA 0.9395 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025100 Css NA 0.1277 mg/L PBTK NA 50% Rat Human -DTXSID5025100 Css NA 0.6011 mg/L PBTK NA 95% Rat Human +DTXSID5025100 TK.Half.Life NA 6.836 hours 1compartment NA NA Rat Human +DTXSID5025100 Css NA 0.04012 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025100 Css NA 0.2826 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025100 Css NA 0.0456 mg/L PBTK NA 50% Rat Human +DTXSID5025100 Css NA 0.196 mg/L PBTK NA 95% Rat Human DTXSID5025102 Clint NA 0.8372 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5025102 Fup NA 0.8213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025102 Vd NA 1.521 L/kg 1compartment NA NA Human Human +DTXSID5025102 Vd NA 1.343 L/kg 1compartment NA NA Human Human DTXSID5025102 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025102 TK.Half.Life NA 5.283 hours 1compartment NA NA Human Human -DTXSID5025102 Css NA 0.3586 mg/L 3compartmentss NA 50% Human Human -DTXSID5025102 Css NA 2.471 mg/L 3compartmentss NA 95% Human Human -DTXSID5025102 Css NA 0.339 mg/L PBTK NA 50% Human Human -DTXSID5025102 Css NA 1.72 mg/L PBTK NA 95% Human Human +DTXSID5025102 TK.Half.Life NA 4.68 hours 1compartment NA NA Human Human +DTXSID5025102 Css NA 0.3164 mg/L 3compartmentss NA 50% Human Human +DTXSID5025102 Css NA 2.133 mg/L 3compartmentss NA 95% Human Human +DTXSID5025102 Css NA 0.2896 mg/L PBTK NA 50% Human Human +DTXSID5025102 Css NA 1.439 mg/L PBTK NA 95% Human Human DTXSID5025102 Clint NA 0.8372 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5025102 Fup NA 0.8213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025102 Vd NA 1.514 L/kg 1compartment NA NA Rat Human +DTXSID5025102 Vd NA 1.341 L/kg 1compartment NA NA Rat Human DTXSID5025102 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025102 TK.Half.Life NA 2.485 hours 1compartment NA NA Rat Human -DTXSID5025102 Css NA 0.1283 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025102 Css NA 0.8956 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025102 Css NA 0.1216 mg/L PBTK NA 50% Rat Human -DTXSID5025102 Css NA 0.5667 mg/L PBTK NA 95% Rat Human +DTXSID5025102 TK.Half.Life NA 2.204 hours 1compartment NA NA Rat Human +DTXSID5025102 Css NA 0.008126 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025102 Css NA 0.07408 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025102 Css NA 0.007314 mg/L PBTK NA 50% Rat Human +DTXSID5025102 Css NA 0.05047 mg/L PBTK NA 95% Rat Human DTXSID5025150 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5025150 Fup NA 0.5996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025150 Vd NA 0.448 L/kg 1compartment NA NA Human Human +DTXSID5025150 Vd NA 0.6538 L/kg 1compartment NA NA Human Human DTXSID5025150 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025150 TK.Half.Life NA 4.834 hours 1compartment NA NA Human Human -DTXSID5025150 Css NA 1.334 mg/L 3compartmentss NA 50% Human Human -DTXSID5025150 Css NA 8.248 mg/L 3compartmentss NA 95% Human Human -DTXSID5025150 Css NA 0.986 mg/L PBTK NA 50% Human Human -DTXSID5025150 Css NA 5.124 mg/L PBTK NA 95% Human Human +DTXSID5025150 TK.Half.Life NA 7.071 hours 1compartment NA NA Human Human +DTXSID5025150 Css NA 1.05 mg/L 3compartmentss NA 50% Human Human +DTXSID5025150 Css NA 7.333 mg/L 3compartmentss NA 95% Human Human +DTXSID5025150 Css NA 0.8349 mg/L PBTK NA 50% Human Human +DTXSID5025150 Css NA 4.579 mg/L PBTK NA 95% Human Human DTXSID5025150 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5025150 Fup NA 0.5996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025150 Vd NA 0.4692 L/kg 1compartment NA NA Rat Human +DTXSID5025150 Vd NA 0.6681 L/kg 1compartment NA NA Rat Human DTXSID5025150 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025150 TK.Half.Life NA 1.726 hours 1compartment NA NA Rat Human -DTXSID5025150 Css NA 0.3538 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025150 Css NA 2.151 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025150 Css NA 0.249 mg/L PBTK NA 50% Rat Human -DTXSID5025150 Css NA 1.233 mg/L PBTK NA 95% Rat Human +DTXSID5025150 TK.Half.Life NA 2.458 hours 1compartment NA NA Rat Human +DTXSID5025150 Css NA 0.02028 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025150 Css NA 0.1715 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025150 Css NA 0.01556 mg/L PBTK NA 50% Rat Human +DTXSID5025150 Css NA 0.1068 mg/L PBTK NA 95% Rat Human DTXSID5025152 Clint 364.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5025152 Fup 0.9999 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5025152 Vd NA 1.048 L/kg 1compartment NA NA Human Human DTXSID5025152 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5025152 TK.Half.Life NA 0.5563 hours 1compartment NA NA Human Human -DTXSID5025152 Css NA 0.001428 mg/L 3compartmentss NA 50% Human Human -DTXSID5025152 Css NA 0.01975 mg/L 3compartmentss NA 95% Human Human -DTXSID5025152 Css NA 0.001246 mg/L PBTK NA 50% Human Human -DTXSID5025152 Css NA 0.01479 mg/L PBTK NA 95% Human Human +DTXSID5025152 Css NA 0.000604 mg/L 3compartmentss NA 50% Human Human +DTXSID5025152 Css NA 0.01616 mg/L 3compartmentss NA 95% Human Human +DTXSID5025152 Css NA 0.0005291 mg/L PBTK NA 50% Human Human +DTXSID5025152 Css NA 0.01204 mg/L PBTK NA 95% Human Human DTXSID5025152 Clint 364.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5025152 Fup 0.9999 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5025152 Vd NA 1.041 L/kg 1compartment NA NA Rat Human DTXSID5025152 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5025152 TK.Half.Life NA 0.2389 hours 1compartment NA NA Rat Human -DTXSID5025152 Css NA 0.0007223 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025152 Css NA 0.008685 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025152 Css NA 0.0006294 mg/L PBTK NA 50% Rat Human -DTXSID5025152 Css NA 0.006369 mg/L PBTK NA 95% Rat Human -DTXSID5025156 Clint NA 0.0276 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025156 Fup NA 0.991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025156 Vd NA 0.8471 L/kg 1compartment NA NA Human Human +DTXSID5025152 Css NA 8.009e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025152 Css NA 0.001694 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025152 Css NA 7.418e-05 mg/L PBTK NA 50% Rat Human +DTXSID5025152 Css NA 0.00131 mg/L PBTK NA 95% Rat Human +DTXSID5025156 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025156 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025156 Vd NA 0.5349 L/kg 1compartment NA NA Human Human DTXSID5025156 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025156 TK.Half.Life NA 5.303 hours 1compartment NA NA Human Human -DTXSID5025156 Css NA 0.7615 mg/L 3compartmentss NA 50% Human Human -DTXSID5025156 Css NA 5.589 mg/L 3compartmentss NA 95% Human Human -DTXSID5025156 Css NA 0.6574 mg/L PBTK NA 50% Human Human -DTXSID5025156 Css NA 3.65 mg/L PBTK NA 95% Human Human -DTXSID5025156 Clint NA 0.0276 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025156 Fup NA 0.991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025156 Vd NA 0.8742 L/kg 1compartment NA NA Rat Human +DTXSID5025156 TK.Half.Life NA 7.63 hours 1compartment NA NA Human Human +DTXSID5025156 Css NA 1.361 mg/L 3compartmentss NA 50% Human Human +DTXSID5025156 Css NA 6.612 mg/L 3compartmentss NA 95% Human Human +DTXSID5025156 Css NA 1.014 mg/L PBTK NA 50% Human Human +DTXSID5025156 Css NA 4.141 mg/L PBTK NA 95% Human Human +DTXSID5025156 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025156 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025156 Vd NA 0.5498 L/kg 1compartment NA NA Rat Human DTXSID5025156 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025156 TK.Half.Life NA 1.904 hours 1compartment NA NA Rat Human -DTXSID5025156 Css NA 0.1981 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025156 Css NA 1.424 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025156 Css NA 0.1676 mg/L PBTK NA 50% Rat Human -DTXSID5025156 Css NA 0.8562 mg/L PBTK NA 95% Rat Human -DTXSID5025231 Clint NA 4.667 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025231 Fup NA 0.0191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025231 Vd NA 0.2434 L/kg 1compartment NA NA Human Human +DTXSID5025156 TK.Half.Life NA 2.671 hours 1compartment NA NA Rat Human +DTXSID5025156 Css NA 0.02525 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025156 Css NA 0.1691 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025156 Css NA 0.01824 mg/L PBTK NA 50% Rat Human +DTXSID5025156 Css NA 0.1064 mg/L PBTK NA 95% Rat Human +DTXSID5025231 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025231 Fup 0.0492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025231 Vd NA 0.4014 L/kg 1compartment NA NA Human Human DTXSID5025231 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025231 TK.Half.Life NA 9.383 hours 1compartment NA NA Human Human -DTXSID5025231 Css NA 7.137 mg/L 3compartmentss NA 50% Human Human -DTXSID5025231 Css NA 58.39 mg/L 3compartmentss NA 95% Human Human -DTXSID5025231 Css NA 4.2 mg/L PBTK NA 50% Human Human -DTXSID5025231 Css NA 33.81 mg/L PBTK NA 95% Human Human -DTXSID5025231 Clint NA 4.667 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025231 Fup NA 0.0191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025231 Vd NA 0.2183 L/kg 1compartment NA NA Rat Human +DTXSID5025231 TK.Half.Life NA 1.743 hours 1compartment NA NA Human Human +DTXSID5025231 Css NA 0.6146 mg/L 3compartmentss NA 50% Human Human +DTXSID5025231 Css NA 5.228 mg/L 3compartmentss NA 95% Human Human +DTXSID5025231 Css NA 0.3732 mg/L PBTK NA 50% Human Human +DTXSID5025231 Css NA 3.073 mg/L PBTK NA 95% Human Human +DTXSID5025231 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025231 Fup 0.0492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025231 Vd 0.62 0.3376 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID5025231 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025231 TK.Half.Life NA 5.227 hours 1compartment NA NA Rat Human -DTXSID5025231 Css NA 3.676 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025231 Css NA 23.72 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025231 Css NA 2.024 mg/L PBTK NA 50% Rat Human -DTXSID5025231 Css NA 12.84 mg/L PBTK NA 95% Rat Human +DTXSID5025231 TK.Half.Life 0.23 0.9108 hours 1compartment National Toxicology Program NA Rat Human +DTXSID5025231 Css 0.022 0.07942 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID5025231 Css 0.022 0.5299 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID5025231 Css 0.022 0.04664 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID5025231 Css 0.022 0.3029 mg/L PBTK National Toxicology Program 95% Rat Human DTXSID5025237 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5025237 Fup NA 0.8668 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5025237 Vd NA 1.17 L/kg 1compartment NA NA Human Human DTXSID5025237 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5025237 TK.Half.Life NA 9.124 hours 1compartment NA NA Human Human -DTXSID5025237 Css NA 0.8913 mg/L 3compartmentss NA 50% Human Human -DTXSID5025237 Css NA 5.067 mg/L 3compartmentss NA 95% Human Human -DTXSID5025237 Css NA 0.7989 mg/L PBTK NA 50% Human Human -DTXSID5025237 Css NA 3.426 mg/L PBTK NA 95% Human Human +DTXSID5025237 Css NA 0.7434 mg/L 3compartmentss NA 50% Human Human +DTXSID5025237 Css NA 4.615 mg/L 3compartmentss NA 95% Human Human +DTXSID5025237 Css NA 0.6716 mg/L PBTK NA 50% Human Human +DTXSID5025237 Css NA 3.067 mg/L PBTK NA 95% Human Human DTXSID5025237 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5025237 Fup NA 0.8668 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5025237 Vd NA 1.113 L/kg 1compartment NA NA Rat Human DTXSID5025237 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5025237 TK.Half.Life NA 2.862 hours 1compartment NA NA Rat Human -DTXSID5025237 Css NA 0.2253 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025237 Css NA 1.363 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025237 Css NA 0.198 mg/L PBTK NA 50% Rat Human -DTXSID5025237 Css NA 0.8444 mg/L PBTK NA 95% Rat Human -DTXSID5025310 Clint NA 3.426 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025310 Fup NA 0.253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025310 Vd NA 0.9122 L/kg 1compartment NA NA Human Human +DTXSID5025237 Css NA 0.01388 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025237 Css NA 0.1064 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025237 Css NA 0.0121 mg/L PBTK NA 50% Rat Human +DTXSID5025237 Css NA 0.07377 mg/L PBTK NA 95% Rat Human +DTXSID5025310 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025310 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025310 Vd NA 1.156 L/kg 1compartment NA NA Human Human DTXSID5025310 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025310 TK.Half.Life NA 4.136 hours 1compartment NA NA Human Human -DTXSID5025310 Css NA 0.4676 mg/L 3compartmentss NA 50% Human Human -DTXSID5025310 Css NA 2.61 mg/L 3compartmentss NA 95% Human Human -DTXSID5025310 Css NA 0.3374 mg/L PBTK NA 50% Human Human -DTXSID5025310 Css NA 1.722 mg/L PBTK NA 95% Human Human -DTXSID5025310 Clint NA 3.426 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025310 Fup NA 0.253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025310 Vd NA 0.7819 L/kg 1compartment NA NA Rat Human +DTXSID5025310 TK.Half.Life NA 2.922 hours 1compartment NA NA Human Human +DTXSID5025310 Css NA 0.2116 mg/L 3compartmentss NA 50% Human Human +DTXSID5025310 Css NA 1.343 mg/L 3compartmentss NA 95% Human Human +DTXSID5025310 Css NA 0.1592 mg/L PBTK NA 50% Human Human +DTXSID5025310 Css NA 0.9202 mg/L PBTK NA 95% Human Human +DTXSID5025310 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025310 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025310 Vd NA 0.9756 L/kg 1compartment NA NA Rat Human DTXSID5025310 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025310 TK.Half.Life NA 1.935 hours 1compartment NA NA Rat Human -DTXSID5025310 Css NA 0.2312 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025310 Css NA 0.9114 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025310 Css NA 0.1588 mg/L PBTK NA 50% Rat Human -DTXSID5025310 Css NA 0.5558 mg/L PBTK NA 95% Rat Human -DTXSID5025312 Clint NA 0.09406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025312 Fup NA 0.72 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025312 Vd NA 2.051 L/kg 1compartment NA NA Human Human -DTXSID5025312 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5025312 TK.Half.Life NA 15.97 hours 1compartment NA NA Human Human -DTXSID5025312 Css NA 0.7235 mg/L 3compartmentss NA 50% Human Human -DTXSID5025312 Css NA 5.202 mg/L 3compartmentss NA 95% Human Human -DTXSID5025312 Css NA 0.7376 mg/L PBTK NA 50% Human Human -DTXSID5025312 Css NA 3.581 mg/L PBTK NA 95% Human Human -DTXSID5025312 Clint NA 0.09406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025312 Fup NA 0.72 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025312 Vd NA 2.081 L/kg 1compartment NA NA Rat Human +DTXSID5025310 TK.Half.Life NA 1.319 hours 1compartment NA NA Rat Human +DTXSID5025310 Css NA 0.025 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025310 Css NA 0.1189 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025310 Css NA 0.01881 mg/L PBTK NA 50% Rat Human +DTXSID5025310 Css NA 0.07769 mg/L PBTK NA 95% Rat Human +DTXSID5025312 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025312 Fup 0.693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025312 Vd NA 2.038 L/kg 1compartment NA NA Human Human +DTXSID5025312 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5025312 TK.Half.Life NA 19.04 hours 1compartment NA NA Human Human +DTXSID5025312 Css NA 0.7488 mg/L 3compartmentss NA 50% Human Human +DTXSID5025312 Css NA 5.647 mg/L 3compartmentss NA 95% Human Human +DTXSID5025312 Css NA 0.76 mg/L PBTK NA 50% Human Human +DTXSID5025312 Css NA 3.856 mg/L PBTK NA 95% Human Human +DTXSID5025312 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025312 Fup 0.693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025312 Vd NA 2.067 L/kg 1compartment NA NA Rat Human DTXSID5025312 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025312 TK.Half.Life NA 5.924 hours 1compartment NA NA Rat Human -DTXSID5025312 Css NA 0.202 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025312 Css NA 1.517 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025312 Css NA 0.2015 mg/L PBTK NA 50% Rat Human -DTXSID5025312 Css NA 0.9636 mg/L PBTK NA 95% Rat Human +DTXSID5025312 TK.Half.Life NA 6.576 hours 1compartment NA NA Rat Human +DTXSID5025312 Css NA 0.01404 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025312 Css NA 0.1351 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025312 Css NA 0.01374 mg/L PBTK NA 50% Rat Human +DTXSID5025312 Css NA 0.09558 mg/L PBTK NA 95% Rat Human DTXSID5025364 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5025364 Fup NA 0.6065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025364 Vd NA 0.685 L/kg 1compartment NA NA Human Human +DTXSID5025364 Vd NA 0.5868 L/kg 1compartment NA NA Human Human DTXSID5025364 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025364 TK.Half.Life NA 7.334 hours 1compartment NA NA Human Human -DTXSID5025364 Css NA 1.216 mg/L 3compartmentss NA 50% Human Human -DTXSID5025364 Css NA 8.023 mg/L 3compartmentss NA 95% Human Human -DTXSID5025364 Css NA 0.9703 mg/L PBTK NA 50% Human Human -DTXSID5025364 Css NA 5.094 mg/L PBTK NA 95% Human Human +DTXSID5025364 TK.Half.Life NA 6.261 hours 1compartment NA NA Human Human +DTXSID5025364 Css NA 1.066 mg/L 3compartmentss NA 50% Human Human +DTXSID5025364 Css NA 7.071 mg/L 3compartmentss NA 95% Human Human +DTXSID5025364 Css NA 0.8325 mg/L PBTK NA 50% Human Human +DTXSID5025364 Css NA 4.486 mg/L PBTK NA 95% Human Human DTXSID5025364 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5025364 Fup NA 0.6065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025364 Vd NA 0.695 L/kg 1compartment NA NA Rat Human +DTXSID5025364 Vd NA 0.6122 L/kg 1compartment NA NA Rat Human DTXSID5025364 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025364 TK.Half.Life NA 2.529 hours 1compartment NA NA Rat Human -DTXSID5025364 Css NA 0.3219 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025364 Css NA 2.022 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025364 Css NA 0.2464 mg/L PBTK NA 50% Rat Human -DTXSID5025364 Css NA 1.187 mg/L PBTK NA 95% Rat Human -DTXSID5025449 Clint NA 2.403 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025449 Fup NA 0.3287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025449 Vd NA 2.593 L/kg 1compartment NA NA Human Human -DTXSID5025449 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5025449 TK.Half.Life NA 27.69 hours 1compartment NA NA Human Human -DTXSID5025449 Css NA 1.179 mg/L 3compartmentss NA 50% Human Human -DTXSID5025449 Css NA 4.907 mg/L 3compartmentss NA 95% Human Human -DTXSID5025449 Css NA 0.8948 mg/L PBTK NA 50% Human Human -DTXSID5025449 Css NA 3.452 mg/L PBTK NA 95% Human Human -DTXSID5025449 Clint NA 2.403 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025449 Fup NA 0.3287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025449 Vd NA 1.993 L/kg 1compartment NA NA Rat Human -DTXSID5025449 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5025449 TK.Half.Life NA 6.183 hours 1compartment NA NA Rat Human -DTXSID5025449 Css NA 0.5489 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025449 Css NA 1.707 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025449 Css NA 0.3998 mg/L PBTK NA 50% Rat Human -DTXSID5025449 Css NA 1.117 mg/L PBTK NA 95% Rat Human -DTXSID5025491 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025491 Fup NA 0.1362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025491 Vd NA 2.765 L/kg 1compartment NA NA Human Human -DTXSID5025491 Days.Css NA 159 Days PBTK NA NA Human Human -DTXSID5025491 TK.Half.Life NA 651.5 hours 1compartment NA NA Human Human -DTXSID5025491 Css NA 28.34 mg/L 3compartmentss NA 50% Human Human -DTXSID5025491 Css NA 84.4 mg/L 3compartmentss NA 95% Human Human -DTXSID5025491 Css NA 19.93 mg/L PBTK NA 50% Human Human -DTXSID5025491 Css NA 54.44 mg/L PBTK NA 95% Human Human -DTXSID5025491 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025491 Fup NA 0.1362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025491 Vd NA 2.085 L/kg 1compartment NA NA Rat Human -DTXSID5025491 Days.Css NA 39 Days PBTK NA NA Rat Human -DTXSID5025491 TK.Half.Life NA 65.58 hours 1compartment NA NA Rat Human -DTXSID5025491 Css NA 7.667 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025491 Css NA 18.85 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025491 Css NA 5.157 mg/L PBTK NA 50% Rat Human -DTXSID5025491 Css NA 11.32 mg/L PBTK NA 95% Rat Human -DTXSID5025570 Clint NA 20.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025570 Fup NA 0.6951 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025570 Vd NA 1.028 L/kg 1compartment NA NA Human Human +DTXSID5025364 TK.Half.Life NA 2.227 hours 1compartment NA NA Rat Human +DTXSID5025364 Css NA 0.02047 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025364 Css NA 0.1799 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025364 Css NA 0.01528 mg/L PBTK NA 50% Rat Human +DTXSID5025364 Css NA 0.1131 mg/L PBTK NA 95% Rat Human +DTXSID5025449 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025449 Fup 0.0662 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025449 Vd NA 1.527 L/kg 1compartment NA NA Human Human +DTXSID5025449 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5025449 TK.Half.Life NA 5.874 hours 1compartment NA NA Human Human +DTXSID5025449 Css NA 0.4216 mg/L 3compartmentss NA 50% Human Human +DTXSID5025449 Css NA 3.13 mg/L 3compartmentss NA 95% Human Human +DTXSID5025449 Css NA 0.2736 mg/L PBTK NA 50% Human Human +DTXSID5025449 Css NA 1.927 mg/L PBTK NA 95% Human Human +DTXSID5025449 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025449 Fup 0.0662 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025449 Vd NA 1.155 L/kg 1compartment NA NA Rat Human +DTXSID5025449 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5025449 TK.Half.Life NA 2.253 hours 1compartment NA NA Rat Human +DTXSID5025449 Css NA 0.02085 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025449 Css NA 0.1614 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025449 Css NA 0.01311 mg/L PBTK NA 50% Rat Human +DTXSID5025449 Css NA 0.09777 mg/L PBTK NA 95% Rat Human +DTXSID5025491 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025491 Fup 0.0975 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025491 Vd NA 2.357 L/kg 1compartment NA NA Human Human +DTXSID5025491 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5025491 TK.Half.Life NA 9.549 hours 1compartment NA NA Human Human +DTXSID5025491 Css NA 0.4537 mg/L 3compartmentss NA 50% Human Human +DTXSID5025491 Css NA 3.127 mg/L 3compartmentss NA 95% Human Human +DTXSID5025491 Css NA 0.3107 mg/L PBTK NA 50% Human Human +DTXSID5025491 Css NA 2.051 mg/L PBTK NA 95% Human Human +DTXSID5025491 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025491 Fup 0.0975 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025491 Vd NA 1.778 L/kg 1compartment NA NA Rat Human +DTXSID5025491 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5025491 TK.Half.Life NA 2.712 hours 1compartment NA NA Rat Human +DTXSID5025491 Css NA 0.05794 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025491 Css NA 0.3167 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025491 Css NA 0.03903 mg/L PBTK NA 50% Rat Human +DTXSID5025491 Css NA 0.2056 mg/L PBTK NA 95% Rat Human +DTXSID5025493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025493 Fup 0.0692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025493 Vd NA 2.662 L/kg 1compartment NA NA Human Human +DTXSID5025493 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5025493 TK.Half.Life NA 17.67 hours 1compartment NA NA Human Human +DTXSID5025493 Css NA 0.7936 mg/L 3compartmentss NA 50% Human Human +DTXSID5025493 Css NA 5.058 mg/L 3compartmentss NA 95% Human Human +DTXSID5025493 Css NA 0.539 mg/L PBTK NA 50% Human Human +DTXSID5025493 Css NA 3.393 mg/L PBTK NA 95% Human Human +DTXSID5025493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025493 Fup 0.0692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025493 Vd NA 1.998 L/kg 1compartment NA NA Rat Human +DTXSID5025493 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5025493 TK.Half.Life NA 4.065 hours 1compartment NA NA Rat Human +DTXSID5025493 Css NA 0.1019 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025493 Css NA 0.5401 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025493 Css NA 0.06857 mg/L PBTK NA 50% Rat Human +DTXSID5025493 Css NA 0.3554 mg/L PBTK NA 95% Rat Human +DTXSID5025570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025570 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025570 Vd NA 0.7989 L/kg 1compartment NA NA Human Human DTXSID5025570 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025570 TK.Half.Life NA 0.8562 hours 1compartment NA NA Human Human -DTXSID5025570 Css NA 0.0325 mg/L 3compartmentss NA 50% Human Human -DTXSID5025570 Css NA 0.3329 mg/L 3compartmentss NA 95% Human Human -DTXSID5025570 Css NA 0.0274 mg/L PBTK NA 50% Human Human -DTXSID5025570 Css NA 0.2365 mg/L PBTK NA 95% Human Human -DTXSID5025570 Clint NA 20.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025570 Fup NA 0.6951 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025570 Vd NA 0.9755 L/kg 1compartment NA NA Rat Human +DTXSID5025570 TK.Half.Life NA 0.831 hours 1compartment NA NA Human Human +DTXSID5025570 Css NA 0.04144 mg/L 3compartmentss NA 50% Human Human +DTXSID5025570 Css NA 0.3717 mg/L 3compartmentss NA 95% Human Human +DTXSID5025570 Css NA 0.03218 mg/L PBTK NA 50% Human Human +DTXSID5025570 Css NA 0.2535 mg/L PBTK NA 95% Human Human +DTXSID5025570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025570 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025570 Vd NA 0.7554 L/kg 1compartment NA NA Rat Human DTXSID5025570 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025570 TK.Half.Life NA 0.3986 hours 1compartment NA NA Rat Human -DTXSID5025570 Css NA 0.01646 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025570 Css NA 0.1508 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025570 Css NA 0.0138 mg/L PBTK NA 50% Rat Human -DTXSID5025570 Css NA 0.09817 mg/L PBTK NA 95% Rat Human -DTXSID5025572 Clint NA 97.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025572 Fup NA 0.4666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025572 Vd NA 1.849 L/kg 1compartment NA NA Human Human -DTXSID5025572 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025572 TK.Half.Life NA 1.404 hours 1compartment NA NA Human Human -DTXSID5025572 Css NA 0.01278 mg/L 3compartmentss NA 50% Human Human -DTXSID5025572 Css NA 0.1007 mg/L 3compartmentss NA 95% Human Human -DTXSID5025572 Css NA 0.01048 mg/L PBTK NA 50% Human Human -DTXSID5025572 Css NA 0.07156 mg/L PBTK NA 95% Human Human -DTXSID5025572 Clint NA 97.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025572 Fup NA 0.4666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025572 Vd NA 1.504 L/kg 1compartment NA NA Rat Human -DTXSID5025572 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025572 TK.Half.Life NA 0.503 hours 1compartment NA NA Rat Human -DTXSID5025572 Css NA 0.006835 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025572 Css NA 0.04476 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025572 Css NA 0.005444 mg/L PBTK NA 50% Rat Human -DTXSID5025572 Css NA 0.03268 mg/L PBTK NA 95% Rat Human -DTXSID5025574 Clint NA 6.257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025574 Fup NA 0.4851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025574 Vd NA 1.284 L/kg 1compartment NA NA Human Human +DTXSID5025570 TK.Half.Life NA 0.3988 hours 1compartment NA NA Rat Human +DTXSID5025570 Css NA 0.005122 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025570 Css NA 0.03608 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025570 Css NA 0.00399 mg/L PBTK NA 50% Rat Human +DTXSID5025570 Css NA 0.0244 mg/L PBTK NA 95% Rat Human +DTXSID5025574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025574 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025574 Vd NA 1.1 L/kg 1compartment NA NA Human Human DTXSID5025574 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025574 TK.Half.Life NA 2.345 hours 1compartment NA NA Human Human -DTXSID5025574 Css NA 0.1414 mg/L 3compartmentss NA 50% Human Human -DTXSID5025574 Css NA 0.9992 mg/L 3compartmentss NA 95% Human Human -DTXSID5025574 Css NA 0.1165 mg/L PBTK NA 50% Human Human -DTXSID5025574 Css NA 0.6922 mg/L PBTK NA 95% Human Human -DTXSID5025574 Clint NA 6.257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025574 Fup NA 0.4851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025574 Vd NA 1.112 L/kg 1compartment NA NA Rat Human +DTXSID5025574 TK.Half.Life NA 1.286 hours 1compartment NA NA Human Human +DTXSID5025574 Css NA 0.05436 mg/L 3compartmentss NA 50% Human Human +DTXSID5025574 Css NA 0.4259 mg/L 3compartmentss NA 95% Human Human +DTXSID5025574 Css NA 0.04207 mg/L PBTK NA 50% Human Human +DTXSID5025574 Css NA 0.2957 mg/L PBTK NA 95% Human Human +DTXSID5025574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025574 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025574 Vd NA 0.9506 L/kg 1compartment NA NA Rat Human DTXSID5025574 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025574 TK.Half.Life NA 1.056 hours 1compartment NA NA Rat Human -DTXSID5025574 Css NA 0.06968 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025574 Css NA 0.4106 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025574 Css NA 0.05544 mg/L PBTK NA 50% Rat Human -DTXSID5025574 Css NA 0.2661 mg/L PBTK NA 95% Rat Human +DTXSID5025574 TK.Half.Life NA 0.5635 hours 1compartment NA NA Rat Human +DTXSID5025574 Css NA 0.006811 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025574 Css NA 0.04102 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025574 Css NA 0.005222 mg/L PBTK NA 50% Rat Human +DTXSID5025574 Css NA 0.02774 mg/L PBTK NA 95% Rat Human DTXSID5025603 Clint NA 0.4105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5025603 Fup NA 0.7832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5025603 Vd NA 1.352 L/kg 1compartment NA NA Human Human DTXSID5025603 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5025603 TK.Half.Life NA 6.769 hours 1compartment NA NA Human Human -DTXSID5025603 Css NA 0.5189 mg/L 3compartmentss NA 50% Human Human -DTXSID5025603 Css NA 3.585 mg/L 3compartmentss NA 95% Human Human -DTXSID5025603 Css NA 0.4844 mg/L PBTK NA 50% Human Human -DTXSID5025603 Css NA 2.419 mg/L PBTK NA 95% Human Human +DTXSID5025603 Css NA 0.4414 mg/L 3compartmentss NA 50% Human Human +DTXSID5025603 Css NA 2.968 mg/L 3compartmentss NA 95% Human Human +DTXSID5025603 Css NA 0.4114 mg/L PBTK NA 50% Human Human +DTXSID5025603 Css NA 2 mg/L PBTK NA 95% Human Human DTXSID5025603 Clint NA 0.4105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5025603 Fup NA 0.7832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5025603 Vd NA 1.366 L/kg 1compartment NA NA Rat Human DTXSID5025603 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5025603 TK.Half.Life NA 2.911 hours 1compartment NA NA Rat Human -DTXSID5025603 Css NA 0.1696 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025603 Css NA 1.175 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025603 Css NA 0.1549 mg/L PBTK NA 50% Rat Human -DTXSID5025603 Css NA 0.7257 mg/L PBTK NA 95% Rat Human -DTXSID5025653 Clint NA 5.689 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025653 Fup NA 0.4669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025653 Vd NA 2.335 L/kg 1compartment NA NA Human Human +DTXSID5025603 Css NA 0.01032 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025603 Css NA 0.09631 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025603 Css NA 0.009365 mg/L PBTK NA 50% Rat Human +DTXSID5025603 Css NA 0.06577 mg/L PBTK NA 95% Rat Human +DTXSID5025607 Clint 26.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID5025607 Fup 0.1416 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID5025607 Vd NA 1.541 L/kg 1compartment NA NA Human Human +DTXSID5025607 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5025607 TK.Half.Life NA 3.081 hours 1compartment NA NA Human Human +DTXSID5025607 Css NA 0.169 mg/L 3compartmentss NA 50% Human Human +DTXSID5025607 Css NA 1.327 mg/L 3compartmentss NA 95% Human Human +DTXSID5025607 Css NA 0.1162 mg/L PBTK NA 50% Human Human +DTXSID5025607 Css NA 0.8407 mg/L PBTK NA 95% Human Human +DTXSID5025607 Clint 26.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID5025607 Fup 0.1416 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID5025607 Vd NA 1.193 L/kg 1compartment NA NA Rat Human +DTXSID5025607 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5025607 TK.Half.Life NA 1.179 hours 1compartment NA NA Rat Human +DTXSID5025607 Css NA 0.022 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025607 Css NA 0.1315 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025607 Css NA 0.01484 mg/L PBTK NA 50% Rat Human +DTXSID5025607 Css NA 0.08256 mg/L PBTK NA 95% Rat Human +DTXSID5025653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025653 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025653 Vd NA 1.799 L/kg 1compartment NA NA Human Human DTXSID5025653 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025653 TK.Half.Life NA 6.87 hours 1compartment NA NA Human Human -DTXSID5025653 Css NA 0.2632 mg/L 3compartmentss NA 50% Human Human -DTXSID5025653 Css NA 1.526 mg/L 3compartmentss NA 95% Human Human -DTXSID5025653 Css NA 0.2148 mg/L PBTK NA 50% Human Human -DTXSID5025653 Css NA 1.128 mg/L PBTK NA 95% Human Human -DTXSID5025653 Clint NA 5.689 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025653 Fup NA 0.4669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025653 Vd NA 1.853 L/kg 1compartment NA NA Rat Human +DTXSID5025653 TK.Half.Life NA 3.304 hours 1compartment NA NA Human Human +DTXSID5025653 Css NA 0.1279 mg/L 3compartmentss NA 50% Human Human +DTXSID5025653 Css NA 0.8884 mg/L 3compartmentss NA 95% Human Human +DTXSID5025653 Css NA 0.0931 mg/L PBTK NA 50% Human Human +DTXSID5025653 Css NA 0.6113 mg/L PBTK NA 95% Human Human +DTXSID5025653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025653 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025653 Vd NA 1.41 L/kg 1compartment NA NA Rat Human DTXSID5025653 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025653 TK.Half.Life NA 2.128 hours 1compartment NA NA Rat Human -DTXSID5025653 Css NA 0.1332 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025653 Css NA 0.5623 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025653 Css NA 0.1046 mg/L PBTK NA 50% Rat Human -DTXSID5025653 Css NA 0.3851 mg/L PBTK NA 95% Rat Human +DTXSID5025653 TK.Half.Life NA 1.215 hours 1compartment NA NA Rat Human +DTXSID5025653 Css NA 0.01625 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025653 Css NA 0.08607 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025653 Css NA 0.01178 mg/L PBTK NA 50% Rat Human +DTXSID5025653 Css NA 0.05873 mg/L PBTK NA 95% Rat Human DTXSID5025659 Clint 817 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5025659 Fup 0.107 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5025659 Vd NA 1.309 L/kg 1compartment NA NA Human Human +DTXSID5025659 Vd NA 1.297 L/kg 1compartment NA NA Human Human DTXSID5025659 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025659 TK.Half.Life NA 1.163 hours 1compartment NA NA Human Human -DTXSID5025659 Css NA 0.006462 mg/L 3compartmentss NA 50% Human Human -DTXSID5025659 Css NA 0.04555 mg/L 3compartmentss NA 95% Human Human -DTXSID5025659 Css NA 0.004327 mg/L PBTK NA 50% Human Human -DTXSID5025659 Css NA 0.02963 mg/L PBTK NA 95% Human Human +DTXSID5025659 TK.Half.Life NA 1.153 hours 1compartment NA NA Human Human +DTXSID5025659 Css NA 0.004445 mg/L 3compartmentss NA 50% Human Human +DTXSID5025659 Css NA 0.04054 mg/L 3compartmentss NA 95% Human Human +DTXSID5025659 Css NA 0.002966 mg/L PBTK NA 50% Human Human +DTXSID5025659 Css NA 0.02648 mg/L PBTK NA 95% Human Human DTXSID5025659 Clint 817 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5025659 Fup 0.107 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5025659 Vd NA 1.012 L/kg 1compartment NA NA Rat Human +DTXSID5025659 Vd NA 1.003 L/kg 1compartment NA NA Rat Human DTXSID5025659 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025659 TK.Half.Life NA 0.3993 hours 1compartment NA NA Rat Human -DTXSID5025659 Css NA 0.003618 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025659 Css NA 0.0202 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025659 Css NA 0.00231 mg/L PBTK NA 50% Rat Human -DTXSID5025659 Css NA 0.01252 mg/L PBTK NA 95% Rat Human -DTXSID5025730 Clint NA 13.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025730 Fup NA 0.0331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025730 Vd NA 3.011 L/kg 1compartment NA NA Human Human -DTXSID5025730 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID5025730 TK.Half.Life NA 81.27 hours 1compartment NA NA Human Human -DTXSID5025730 Css NA 3.471 mg/L 3compartmentss NA 50% Human Human -DTXSID5025730 Css NA 21.43 mg/L 3compartmentss NA 95% Human Human -DTXSID5025730 Css NA 2.395 mg/L PBTK NA 50% Human Human -DTXSID5025730 Css NA 14.15 mg/L PBTK NA 95% Human Human -DTXSID5025730 Clint NA 13.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025730 Fup NA 0.0331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025730 Vd NA 2.256 L/kg 1compartment NA NA Rat Human -DTXSID5025730 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID5025730 TK.Half.Life NA 12.6 hours 1compartment NA NA Rat Human -DTXSID5025730 Css NA 1.892 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025730 Css NA 9.594 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025730 Css NA 1.245 mg/L PBTK NA 50% Rat Human -DTXSID5025730 Css NA 6.19 mg/L PBTK NA 95% Rat Human -DTXSID5025732 Clint NA 0.1875 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025732 Fup NA 0.7178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025732 Vd NA 1.006 L/kg 1compartment NA NA Human Human +DTXSID5025659 TK.Half.Life NA 0.3959 hours 1compartment NA NA Rat Human +DTXSID5025659 Css NA 0.0006167 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025659 Css NA 0.00451 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025659 Css NA 0.000411 mg/L PBTK NA 50% Rat Human +DTXSID5025659 Css NA 0.002933 mg/L PBTK NA 95% Rat Human +DTXSID5025732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025732 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025732 Vd NA 0.7582 L/kg 1compartment NA NA Human Human DTXSID5025732 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025732 TK.Half.Life NA 7.148 hours 1compartment NA NA Human Human -DTXSID5025732 Css NA 0.7665 mg/L 3compartmentss NA 50% Human Human -DTXSID5025732 Css NA 4.964 mg/L 3compartmentss NA 95% Human Human -DTXSID5025732 Css NA 0.6612 mg/L PBTK NA 50% Human Human -DTXSID5025732 Css NA 3.271 mg/L PBTK NA 95% Human Human -DTXSID5025732 Clint NA 0.1875 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025732 Fup NA 0.7178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025732 Vd NA 0.9632 L/kg 1compartment NA NA Rat Human +DTXSID5025732 TK.Half.Life NA 0.7981 hours 1compartment NA NA Human Human +DTXSID5025732 Css NA 0.04268 mg/L 3compartmentss NA 50% Human Human +DTXSID5025732 Css NA 0.3565 mg/L 3compartmentss NA 95% Human Human +DTXSID5025732 Css NA 0.0326 mg/L PBTK NA 50% Human Human +DTXSID5025732 Css NA 0.245 mg/L PBTK NA 95% Human Human +DTXSID5025732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025732 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025732 Vd NA 0.7235 L/kg 1compartment NA NA Rat Human DTXSID5025732 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025732 TK.Half.Life NA 2.591 hours 1compartment NA NA Rat Human -DTXSID5025732 Css NA 0.2283 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025732 Css NA 1.524 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025732 Css NA 0.1912 mg/L PBTK NA 50% Rat Human -DTXSID5025732 Css NA 0.9169 mg/L PBTK NA 95% Rat Human -DTXSID5025738 Clint NA 0.6144 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025738 Fup NA 0.1822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025738 Vd NA 0.4344 L/kg 1compartment NA NA Human Human -DTXSID5025738 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025738 TK.Half.Life NA 7.707 hours 1compartment NA NA Human Human -DTXSID5025738 Css NA 2.18 mg/L 3compartmentss NA 50% Human Human -DTXSID5025738 Css NA 9.083 mg/L 3compartmentss NA 95% Human Human -DTXSID5025738 Css NA 1.474 mg/L PBTK NA 50% Human Human -DTXSID5025738 Css NA 5.624 mg/L PBTK NA 95% Human Human -DTXSID5025738 Clint NA 0.6144 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025738 Fup NA 0.1822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025738 Vd NA 0.4349 L/kg 1compartment NA NA Rat Human +DTXSID5025732 TK.Half.Life NA 0.3872 hours 1compartment NA NA Rat Human +DTXSID5025732 Css NA 0.00531 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025732 Css NA 0.03487 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025732 Css NA 0.00407 mg/L PBTK NA 50% Rat Human +DTXSID5025732 Css NA 0.02398 mg/L PBTK NA 95% Rat Human +DTXSID5025738 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025738 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025738 Vd NA 0.5209 L/kg 1compartment NA NA Human Human +DTXSID5025738 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5025738 TK.Half.Life NA 13.12 hours 1compartment NA NA Human Human +DTXSID5025738 Css NA 2.799 mg/L 3compartmentss NA 50% Human Human +DTXSID5025738 Css NA 10.73 mg/L 3compartmentss NA 95% Human Human +DTXSID5025738 Css NA 1.996 mg/L PBTK NA 50% Human Human +DTXSID5025738 Css NA 6.901 mg/L PBTK NA 95% Human Human +DTXSID5025738 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025738 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025738 Vd NA 0.523 L/kg 1compartment NA NA Rat Human DTXSID5025738 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025738 TK.Half.Life NA 3.531 hours 1compartment NA NA Rat Human -DTXSID5025738 Css NA 0.8329 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025738 Css NA 2.855 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025738 Css NA 0.532 mg/L PBTK NA 50% Rat Human -DTXSID5025738 Css NA 1.634 mg/L PBTK NA 95% Rat Human -DTXSID5025811 Clint NA 0.5786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025811 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025811 Vd NA 34.9 L/kg 1compartment NA NA Human Human -DTXSID5025811 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID5025811 TK.Half.Life NA 37840 hours 1compartment NA NA Human Human -DTXSID5025811 Css NA 23.9 mg/L 3compartmentss NA 50% Human Human -DTXSID5025811 Css NA 136.9 mg/L 3compartmentss NA 95% Human Human -DTXSID5025811 Css NA 88.65 mg/L PBTK NA 50% Human Human -DTXSID5025811 Css NA 471.1 mg/L PBTK NA 95% Human Human -DTXSID5025811 Clint NA 0.5786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025811 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025811 Vd NA 29 L/kg 1compartment NA NA Rat Human -DTXSID5025811 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID5025811 TK.Half.Life NA 5365 hours 1compartment NA NA Rat Human -DTXSID5025811 Css NA 12.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025811 Css NA 45.95 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025811 Css NA 47.6 mg/L PBTK NA 50% Rat Human -DTXSID5025811 Css NA 175.3 mg/L PBTK NA 95% Rat Human -DTXSID5025815 Clint NA 11.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025815 Fup NA 0.1075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025815 Vd NA 3.025 L/kg 1compartment NA NA Human Human +DTXSID5025738 TK.Half.Life NA 4.486 hours 1compartment NA NA Rat Human +DTXSID5025738 Css NA 0.1792 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025738 Css NA 0.5988 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025738 Css NA 0.1264 mg/L PBTK NA 50% Rat Human +DTXSID5025738 Css NA 0.3653 mg/L PBTK NA 95% Rat Human +DTXSID5025815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025815 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025815 Vd NA 3.133 L/kg 1compartment NA NA Human Human DTXSID5025815 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025815 TK.Half.Life NA 9.483 hours 1compartment NA NA Human Human -DTXSID5025815 Css NA 0.3066 mg/L 3compartmentss NA 50% Human Human -DTXSID5025815 Css NA 2.398 mg/L 3compartmentss NA 95% Human Human -DTXSID5025815 Css NA 0.2601 mg/L PBTK NA 50% Human Human -DTXSID5025815 Css NA 1.809 mg/L PBTK NA 95% Human Human -DTXSID5025815 Clint NA 11.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025815 Fup NA 0.1075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025815 Vd NA 2.76 L/kg 1compartment NA NA Rat Human +DTXSID5025815 TK.Half.Life NA 5.303 hours 1compartment NA NA Human Human +DTXSID5025815 Css NA 0.1186 mg/L 3compartmentss NA 50% Human Human +DTXSID5025815 Css NA 1.082 mg/L 3compartmentss NA 95% Human Human +DTXSID5025815 Css NA 0.1074 mg/L PBTK NA 50% Human Human +DTXSID5025815 Css NA 0.8226 mg/L PBTK NA 95% Human Human +DTXSID5025815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025815 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025815 Vd NA 2.925 L/kg 1compartment NA NA Rat Human DTXSID5025815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025815 TK.Half.Life NA 4.276 hours 1compartment NA NA Rat Human -DTXSID5025815 Css NA 0.1656 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025815 Css NA 0.9888 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025815 Css NA 0.137 mg/L PBTK NA 50% Rat Human -DTXSID5025815 Css NA 0.6895 mg/L PBTK NA 95% Rat Human -DTXSID5025861 Clint NA 22.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025861 Fup NA 0.04 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025861 Vd NA 0.6073 L/kg 1compartment NA NA Human Human +DTXSID5025815 TK.Half.Life NA 2.497 hours 1compartment NA NA Rat Human +DTXSID5025815 Css NA 0.01534 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025815 Css NA 0.1022 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025815 Css NA 0.01392 mg/L PBTK NA 50% Rat Human +DTXSID5025815 Css NA 0.0791 mg/L PBTK NA 95% Rat Human +DTXSID5025861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025861 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025861 Vd NA 1.192 L/kg 1compartment NA NA Human Human DTXSID5025861 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025861 TK.Half.Life NA 2.984 hours 1compartment NA NA Human Human -DTXSID5025861 Css NA 0.7476 mg/L 3compartmentss NA 50% Human Human -DTXSID5025861 Css NA 7.025 mg/L 3compartmentss NA 95% Human Human -DTXSID5025861 Css NA 0.4566 mg/L PBTK NA 50% Human Human -DTXSID5025861 Css NA 4.147 mg/L PBTK NA 95% Human Human -DTXSID5025861 Clint NA 22.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025861 Fup NA 0.04 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025861 Vd NA 0.4795 L/kg 1compartment NA NA Rat Human +DTXSID5025861 TK.Half.Life NA 2.613 hours 1compartment NA NA Human Human +DTXSID5025861 Css NA 0.205 mg/L 3compartmentss NA 50% Human Human +DTXSID5025861 Css NA 1.579 mg/L 3compartmentss NA 95% Human Human +DTXSID5025861 Css NA 0.1377 mg/L PBTK NA 50% Human Human +DTXSID5025861 Css NA 1.013 mg/L PBTK NA 95% Human Human +DTXSID5025861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025861 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025861 Vd NA 0.9397 L/kg 1compartment NA NA Rat Human DTXSID5025861 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025861 TK.Half.Life NA 1.449 hours 1compartment NA NA Rat Human -DTXSID5025861 Css NA 0.4258 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025861 Css NA 3.125 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025861 Css NA 0.2422 mg/L PBTK NA 50% Rat Human -DTXSID5025861 Css NA 1.718 mg/L PBTK NA 95% Rat Human -DTXSID5025863 Clint NA 25.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025863 Fup NA 0.498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025863 Vd NA 1.023 L/kg 1compartment NA NA Human Human +DTXSID5025861 TK.Half.Life NA 1.095 hours 1compartment NA NA Rat Human +DTXSID5025861 Css NA 0.0264 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025861 Css NA 0.1609 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025861 Css NA 0.01728 mg/L PBTK NA 50% Rat Human +DTXSID5025861 Css NA 0.09908 mg/L PBTK NA 95% Rat Human +DTXSID5025863 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025863 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025863 Vd NA 0.9889 L/kg 1compartment NA NA Human Human DTXSID5025863 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025863 TK.Half.Life NA 0.9583 hours 1compartment NA NA Human Human -DTXSID5025863 Css NA 0.03573 mg/L 3compartmentss NA 50% Human Human -DTXSID5025863 Css NA 0.3186 mg/L 3compartmentss NA 95% Human Human -DTXSID5025863 Css NA 0.02914 mg/L PBTK NA 50% Human Human -DTXSID5025863 Css NA 0.2223 mg/L PBTK NA 95% Human Human -DTXSID5025863 Clint NA 25.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025863 Fup NA 0.498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025863 Vd NA 0.9294 L/kg 1compartment NA NA Rat Human +DTXSID5025863 TK.Half.Life NA 1.01 hours 1compartment NA NA Human Human +DTXSID5025863 Css NA 0.0409 mg/L 3compartmentss NA 50% Human Human +DTXSID5025863 Css NA 0.3533 mg/L 3compartmentss NA 95% Human Human +DTXSID5025863 Css NA 0.03262 mg/L PBTK NA 50% Human Human +DTXSID5025863 Css NA 0.2479 mg/L PBTK NA 95% Human Human +DTXSID5025863 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025863 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025863 Vd NA 0.8971 L/kg 1compartment NA NA Rat Human DTXSID5025863 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025863 TK.Half.Life NA 0.43 hours 1compartment NA NA Rat Human -DTXSID5025863 Css NA 0.01845 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025863 Css NA 0.1338 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025863 Css NA 0.01462 mg/L PBTK NA 50% Rat Human -DTXSID5025863 Css NA 0.0872 mg/L PBTK NA 95% Rat Human -DTXSID5025948 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025948 Fup NA 0.6349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025948 Vd NA 0.59 L/kg 1compartment NA NA Human Human -DTXSID5025948 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5025948 TK.Half.Life NA 6.012 hours 1compartment NA NA Human Human -DTXSID5025948 Css NA 1.201 mg/L 3compartmentss NA 50% Human Human -DTXSID5025948 Css NA 7.815 mg/L 3compartmentss NA 95% Human Human -DTXSID5025948 Css NA 0.9425 mg/L PBTK NA 50% Human Human -DTXSID5025948 Css NA 4.887 mg/L PBTK NA 95% Human Human -DTXSID5025948 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025948 Fup NA 0.6349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025948 Vd NA 0.6188 L/kg 1compartment NA NA Rat Human -DTXSID5025948 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5025948 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human -DTXSID5025948 Css NA 0.3182 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025948 Css NA 1.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025948 Css NA 0.2388 mg/L PBTK NA 50% Rat Human -DTXSID5025948 Css NA 1.082 mg/L PBTK NA 95% Rat Human -DTXSID5025998 Clint NA 19.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025998 Fup NA 0.0327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5025998 Vd NA 8.247 L/kg 1compartment NA NA Human Human -DTXSID5025998 Days.Css NA 55 Days PBTK NA NA Human Human -DTXSID5025998 TK.Half.Life NA 270.8 hours 1compartment NA NA Human Human -DTXSID5025998 Css NA 2.52 mg/L 3compartmentss NA 50% Human Human -DTXSID5025998 Css NA 14.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5025998 Css NA 2.665 mg/L PBTK NA 50% Human Human -DTXSID5025998 Css NA 14.56 mg/L PBTK NA 95% Human Human -DTXSID5025998 Clint NA 19.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025998 Fup NA 0.0327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5025998 Vd NA 6.437 L/kg 1compartment NA NA Rat Human -DTXSID5025998 Days.Css NA 33 Days PBTK NA NA Rat Human -DTXSID5025998 TK.Half.Life NA 36.71 hours 1compartment NA NA Rat Human -DTXSID5025998 Css NA 1.394 mg/L 3compartmentss NA 50% Rat Human -DTXSID5025998 Css NA 5.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID5025998 Css NA 1.448 mg/L PBTK NA 50% Rat Human -DTXSID5025998 Css NA 6.23 mg/L PBTK NA 95% Rat Human -DTXSID5026120 Clint NA 107.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026120 Fup NA 0.0564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026120 Vd NA 2.395 L/kg 1compartment NA NA Human Human +DTXSID5025863 TK.Half.Life NA 0.4609 hours 1compartment NA NA Rat Human +DTXSID5025863 Css NA 0.004951 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025863 Css NA 0.03479 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025863 Css NA 0.004002 mg/L PBTK NA 50% Rat Human +DTXSID5025863 Css NA 0.0238 mg/L PBTK NA 95% Rat Human +DTXSID5025998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025998 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5025998 Vd NA 12.69 L/kg 1compartment NA NA Human Human +DTXSID5025998 Days.Css NA 81 Days PBTK NA NA Human Human +DTXSID5025998 TK.Half.Life NA 378.1 hours 1compartment NA NA Human Human +DTXSID5025998 Css NA 1.675 mg/L 3compartmentss NA 50% Human Human +DTXSID5025998 Css NA 10.11 mg/L 3compartmentss NA 95% Human Human +DTXSID5025998 Css NA 2.362 mg/L PBTK NA 50% Human Human +DTXSID5025998 Css NA 14.04 mg/L PBTK NA 95% Human Human +DTXSID5025998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025998 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5025998 Vd NA 10.09 L/kg 1compartment NA NA Rat Human +DTXSID5025998 Days.Css NA 49 Days PBTK NA NA Rat Human +DTXSID5025998 TK.Half.Life NA 52.83 hours 1compartment NA NA Rat Human +DTXSID5025998 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human +DTXSID5025998 Css NA 0.964 mg/L 3compartmentss NA 95% Rat Human +DTXSID5025998 Css NA 0.3096 mg/L PBTK NA 50% Rat Human +DTXSID5025998 Css NA 1.486 mg/L PBTK NA 95% Rat Human +DTXSID5026097 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5026097 Fup NA 0.0365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5026097 Vd NA 2.509 L/kg 1compartment NA NA Human Human +DTXSID5026097 Days.Css NA 381 Days PBTK NA NA Human Human +DTXSID5026097 TK.Half.Life NA 1478 hours 1compartment NA NA Human Human +DTXSID5026097 Css NA 77.85 mg/L 3compartmentss NA 50% Human Human +DTXSID5026097 Css NA 259.7 mg/L 3compartmentss NA 95% Human Human +DTXSID5026097 Css NA 52.09 mg/L PBTK NA 50% Human Human +DTXSID5026097 Css NA 160.8 mg/L PBTK NA 95% Human Human +DTXSID5026097 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5026097 Fup NA 0.0365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5026097 Vd NA 1.877 L/kg 1compartment NA NA Rat Human +DTXSID5026097 Days.Css NA 95 Days PBTK NA NA Rat Human +DTXSID5026097 TK.Half.Life NA 176.1 hours 1compartment NA NA Rat Human +DTXSID5026097 Css NA 4.98 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026097 Css NA 13.45 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026097 Css NA 3.263 mg/L PBTK NA 50% Rat Human +DTXSID5026097 Css NA 8.051 mg/L PBTK NA 95% Rat Human +DTXSID5026120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026120 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026120 Vd NA 1.673 L/kg 1compartment NA NA Human Human DTXSID5026120 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5026120 TK.Half.Life NA 4.569 hours 1compartment NA NA Human Human -DTXSID5026120 Css NA 0.159 mg/L 3compartmentss NA 50% Human Human -DTXSID5026120 Css NA 1.083 mg/L 3compartmentss NA 95% Human Human -DTXSID5026120 Css NA 0.107 mg/L PBTK NA 50% Human Human -DTXSID5026120 Css NA 0.7002 mg/L PBTK NA 95% Human Human -DTXSID5026120 Clint NA 107.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026120 Fup NA 0.0564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026120 Vd NA 1.796 L/kg 1compartment NA NA Rat Human +DTXSID5026120 TK.Half.Life NA 4.423 hours 1compartment NA NA Human Human +DTXSID5026120 Css NA 0.2704 mg/L 3compartmentss NA 50% Human Human +DTXSID5026120 Css NA 2.077 mg/L 3compartmentss NA 95% Human Human +DTXSID5026120 Css NA 0.1817 mg/L PBTK NA 50% Human Human +DTXSID5026120 Css NA 1.312 mg/L PBTK NA 95% Human Human +DTXSID5026120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026120 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026120 Vd NA 1.282 L/kg 1compartment NA NA Rat Human DTXSID5026120 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5026120 TK.Half.Life NA 1.338 hours 1compartment NA NA Rat Human -DTXSID5026120 Css NA 0.09026 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026120 Css NA 0.5261 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026120 Css NA 0.05762 mg/L PBTK NA 50% Rat Human -DTXSID5026120 Css NA 0.3238 mg/L PBTK NA 95% Rat Human -DTXSID5026124 Clint NA 54.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026124 Fup NA 0.257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026124 Vd NA 0.5547 L/kg 1compartment NA NA Human Human +DTXSID5026120 TK.Half.Life NA 1.641 hours 1compartment NA NA Rat Human +DTXSID5026120 Css NA 0.03464 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026120 Css NA 0.2035 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026120 Css NA 0.02298 mg/L PBTK NA 50% Rat Human +DTXSID5026120 Css NA 0.1269 mg/L PBTK NA 95% Rat Human +DTXSID5026124 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026124 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026124 Vd NA 0.827 L/kg 1compartment NA NA Human Human DTXSID5026124 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5026124 TK.Half.Life NA 0.5844 hours 1compartment NA NA Human Human -DTXSID5026124 Css NA 0.03503 mg/L 3compartmentss NA 50% Human Human -DTXSID5026124 Css NA 0.2698 mg/L 3compartmentss NA 95% Human Human -DTXSID5026124 Css NA 0.02439 mg/L PBTK NA 50% Human Human -DTXSID5026124 Css NA 0.1781 mg/L PBTK NA 95% Human Human -DTXSID5026124 Clint NA 54.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026124 Fup NA 0.257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026124 Vd NA 0.5342 L/kg 1compartment NA NA Rat Human +DTXSID5026124 TK.Half.Life NA 1.369 hours 1compartment NA NA Human Human +DTXSID5026124 Css NA 0.1238 mg/L 3compartmentss NA 50% Human Human +DTXSID5026124 Css NA 0.9534 mg/L 3compartmentss NA 95% Human Human +DTXSID5026124 Css NA 0.0979 mg/L PBTK NA 50% Human Human +DTXSID5026124 Css NA 0.6464 mg/L PBTK NA 95% Human Human +DTXSID5026124 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026124 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026124 Vd NA 0.8015 L/kg 1compartment NA NA Rat Human DTXSID5026124 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5026124 TK.Half.Life NA 0.2784 hours 1compartment NA NA Rat Human -DTXSID5026124 Css NA 0.01926 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026124 Css NA 0.1137 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026124 Css NA 0.01273 mg/L PBTK NA 50% Rat Human -DTXSID5026124 Css NA 0.06987 mg/L PBTK NA 95% Rat Human +DTXSID5026124 TK.Half.Life NA 0.7223 hours 1compartment NA NA Rat Human +DTXSID5026124 Css NA 0.01406 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026124 Css NA 0.09205 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026124 Css NA 0.01122 mg/L PBTK NA 50% Rat Human +DTXSID5026124 Css NA 0.05969 mg/L PBTK NA 95% Rat Human DTXSID5026178 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5026178 Fup NA 0.389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026178 Vd NA 0.3633 L/kg 1compartment NA NA Human Human +DTXSID5026178 Vd NA 0.3551 L/kg 1compartment NA NA Human Human DTXSID5026178 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5026178 TK.Half.Life NA 6.043 hours 1compartment NA NA Human Human -DTXSID5026178 Css NA 2.003 mg/L 3compartmentss NA 50% Human Human -DTXSID5026178 Css NA 8.329 mg/L 3compartmentss NA 95% Human Human -DTXSID5026178 Css NA 1.376 mg/L PBTK NA 50% Human Human -DTXSID5026178 Css NA 5.102 mg/L PBTK NA 95% Human Human +DTXSID5026178 TK.Half.Life NA 5.909 hours 1compartment NA NA Human Human +DTXSID5026178 Css NA 1.954 mg/L 3compartmentss NA 50% Human Human +DTXSID5026178 Css NA 8.209 mg/L 3compartmentss NA 95% Human Human +DTXSID5026178 Css NA 1.338 mg/L PBTK NA 50% Human Human +DTXSID5026178 Css NA 5.003 mg/L PBTK NA 95% Human Human DTXSID5026178 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5026178 Fup NA 0.389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026178 Vd NA 0.3698 L/kg 1compartment NA NA Rat Human +DTXSID5026178 Vd NA 0.3627 L/kg 1compartment NA NA Rat Human DTXSID5026178 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5026178 TK.Half.Life NA 2.096 hours 1compartment NA NA Rat Human -DTXSID5026178 Css NA 0.5546 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026178 Css NA 1.932 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026178 Css NA 0.3589 mg/L PBTK NA 50% Rat Human -DTXSID5026178 Css NA 1.11 mg/L PBTK NA 95% Rat Human +DTXSID5026178 TK.Half.Life NA 2.056 hours 1compartment NA NA Rat Human +DTXSID5026178 Css NA 0.1256 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026178 Css NA 0.4359 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026178 Css NA 0.0838 mg/L PBTK NA 50% Rat Human +DTXSID5026178 Css NA 0.259 mg/L PBTK NA 95% Rat Human DTXSID5026203 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5026203 Fup NA 0.0549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5026203 Vd NA 2.174 L/kg 1compartment NA NA Human Human -DTXSID5026203 Days.Css NA 137 Days PBTK NA NA Human Human +DTXSID5026203 Days.Css NA 138 Days PBTK NA NA Human Human DTXSID5026203 TK.Half.Life NA 566.3 hours 1compartment NA NA Human Human -DTXSID5026203 Css NA 36.36 mg/L 3compartmentss NA 50% Human Human -DTXSID5026203 Css NA 126.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5026203 Css NA 24.09 mg/L PBTK NA 50% Human Human -DTXSID5026203 Css NA 78.49 mg/L PBTK NA 95% Human Human +DTXSID5026203 Css NA 35.25 mg/L 3compartmentss NA 50% Human Human +DTXSID5026203 Css NA 125.3 mg/L 3compartmentss NA 95% Human Human +DTXSID5026203 Css NA 23.45 mg/L PBTK NA 50% Human Human +DTXSID5026203 Css NA 75.99 mg/L PBTK NA 95% Human Human DTXSID5026203 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5026203 Fup NA 0.0549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5026203 Vd NA 1.63 L/kg 1compartment NA NA Rat Human -DTXSID5026203 Days.Css NA 33 Days PBTK NA NA Rat Human +DTXSID5026203 Days.Css NA 32 Days PBTK NA NA Rat Human DTXSID5026203 TK.Half.Life NA 84.31 hours 1compartment NA NA Rat Human -DTXSID5026203 Css NA 9.934 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026203 Css NA 30.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026203 Css NA 6.246 mg/L PBTK NA 50% Rat Human -DTXSID5026203 Css NA 17.19 mg/L PBTK NA 95% Rat Human +DTXSID5026203 Css NA 2.242 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026203 Css NA 6.579 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026203 Css NA 1.459 mg/L PBTK NA 50% Rat Human +DTXSID5026203 Css NA 3.906 mg/L PBTK NA 95% Rat Human DTXSID5026205 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5026205 Fup NA 0.0543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026205 Vd NA 2.272 L/kg 1compartment NA NA Human Human -DTXSID5026205 Days.Css NA 162 Days PBTK NA NA Human Human -DTXSID5026205 TK.Half.Life NA 660.1 hours 1compartment NA NA Human Human -DTXSID5026205 Css NA 40.18 mg/L 3compartmentss NA 50% Human Human -DTXSID5026205 Css NA 138.4 mg/L 3compartmentss NA 95% Human Human -DTXSID5026205 Css NA 26.82 mg/L PBTK NA 50% Human Human -DTXSID5026205 Css NA 84.03 mg/L PBTK NA 95% Human Human +DTXSID5026205 Vd NA 2.206 L/kg 1compartment NA NA Human Human +DTXSID5026205 Days.Css NA 146 Days PBTK NA NA Human Human +DTXSID5026205 TK.Half.Life NA 600.1 hours 1compartment NA NA Human Human +DTXSID5026205 Css NA 36.64 mg/L 3compartmentss NA 50% Human Human +DTXSID5026205 Css NA 126.3 mg/L 3compartmentss NA 95% Human Human +DTXSID5026205 Css NA 24.46 mg/L PBTK NA 50% Human Human +DTXSID5026205 Css NA 78.18 mg/L PBTK NA 95% Human Human DTXSID5026205 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5026205 Fup NA 0.0543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026205 Vd NA 1.704 L/kg 1compartment NA NA Rat Human -DTXSID5026205 Days.Css NA 39 Days PBTK NA NA Rat Human -DTXSID5026205 TK.Half.Life NA 92.93 hours 1compartment NA NA Rat Human -DTXSID5026205 Css NA 10.94 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026205 Css NA 31.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026205 Css NA 6.914 mg/L PBTK NA 50% Rat Human -DTXSID5026205 Css NA 18.35 mg/L PBTK NA 95% Rat Human -DTXSID5026207 Clint NA 7.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026207 Fup NA 0.0141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026207 Vd NA 1.084 L/kg 1compartment NA NA Human Human -DTXSID5026207 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5026207 TK.Half.Life NA 33.88 hours 1compartment NA NA Human Human -DTXSID5026207 Css NA 5.451 mg/L 3compartmentss NA 50% Human Human -DTXSID5026207 Css NA 50 mg/L 3compartmentss NA 95% Human Human -DTXSID5026207 Css NA 3.308 mg/L PBTK NA 50% Human Human -DTXSID5026207 Css NA 28.85 mg/L PBTK NA 95% Human Human -DTXSID5026207 Clint NA 7.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026207 Fup NA 0.0141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026207 Vd NA 0.8003 L/kg 1compartment NA NA Rat Human -DTXSID5026207 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5026207 TK.Half.Life NA 14.22 hours 1compartment NA NA Rat Human -DTXSID5026207 Css NA 2.992 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026207 Css NA 20.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026207 Css NA 1.704 mg/L PBTK NA 50% Rat Human -DTXSID5026207 Css NA 11 mg/L PBTK NA 95% Rat Human -DTXSID5026209 Clint NA 1.487 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026209 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026209 Vd NA 0.5549 L/kg 1compartment NA NA Human Human -DTXSID5026209 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID5026209 TK.Half.Life NA 90.98 hours 1compartment NA NA Human Human -DTXSID5026209 Css NA 29.24 mg/L 3compartmentss NA 50% Human Human -DTXSID5026209 Css NA 208 mg/L 3compartmentss NA 95% Human Human -DTXSID5026209 Css NA 17.34 mg/L PBTK NA 50% Human Human -DTXSID5026209 Css NA 121.4 mg/L PBTK NA 95% Human Human -DTXSID5026209 Clint NA 1.487 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026209 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026209 Vd NA 0.4198 L/kg 1compartment NA NA Rat Human -DTXSID5026209 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID5026209 TK.Half.Life NA 36.69 hours 1compartment NA NA Rat Human -DTXSID5026209 Css NA 13.43 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026209 Css NA 80.11 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026209 Css NA 7.432 mg/L PBTK NA 50% Rat Human -DTXSID5026209 Css NA 43.41 mg/L PBTK NA 95% Rat Human -DTXSID5026251 Clint NA 11.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026251 Fup NA 0.4815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026251 Vd NA 3.138 L/kg 1compartment NA NA Human Human -DTXSID5026251 Days.Css NA 32 Days PBTK NA NA Human Human -DTXSID5026251 TK.Half.Life NA 166.9 hours 1compartment NA NA Human Human -DTXSID5026251 Css NA 6.434 mg/L 3compartmentss NA 50% Human Human -DTXSID5026251 Css NA 40.08 mg/L 3compartmentss NA 95% Human Human -DTXSID5026251 Css NA 4.48 mg/L PBTK NA 50% Human Human -DTXSID5026251 Css NA 27.41 mg/L PBTK NA 95% Human Human -DTXSID5026251 Clint NA 11.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026251 Fup NA 0.4815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026251 Vd NA 2.351 L/kg 1compartment NA NA Rat Human -DTXSID5026251 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID5026251 TK.Half.Life NA 21.42 hours 1compartment NA NA Rat Human -DTXSID5026251 Css NA 3.629 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026251 Css NA 17.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026251 Css NA 2.412 mg/L PBTK NA 50% Rat Human -DTXSID5026251 Css NA 11.42 mg/L PBTK NA 95% Rat Human -DTXSID5026259 Clint NA 622 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026259 Fup NA 0.0649 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026259 Vd NA 1.078 L/kg 1compartment NA NA Human Human +DTXSID5026205 Vd NA 1.654 L/kg 1compartment NA NA Rat Human +DTXSID5026205 Days.Css NA 35 Days PBTK NA NA Rat Human +DTXSID5026205 TK.Half.Life NA 87.72 hours 1compartment NA NA Rat Human +DTXSID5026205 Css NA 2.321 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026205 Css NA 6.815 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026205 Css NA 1.514 mg/L PBTK NA 50% Rat Human +DTXSID5026205 Css NA 4.043 mg/L PBTK NA 95% Rat Human +DTXSID5026207 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026207 Fup 0.0134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026207 Vd NA 1.058 L/kg 1compartment NA NA Human Human +DTXSID5026207 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5026207 TK.Half.Life NA 12.77 hours 1compartment NA NA Human Human +DTXSID5026207 Css NA 2.022 mg/L 3compartmentss NA 50% Human Human +DTXSID5026207 Css NA 19.26 mg/L 3compartmentss NA 95% Human Human +DTXSID5026207 Css NA 1.232 mg/L PBTK NA 50% Human Human +DTXSID5026207 Css NA 11.4 mg/L PBTK NA 95% Human Human +DTXSID5026207 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026207 Fup 0.0134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026207 Vd NA 0.7807 L/kg 1compartment NA NA Rat Human +DTXSID5026207 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5026207 TK.Half.Life NA 5.519 hours 1compartment NA NA Rat Human +DTXSID5026207 Css NA 0.2639 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026207 Css NA 1.993 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026207 Css NA 0.155 mg/L PBTK NA 50% Rat Human +DTXSID5026207 Css NA 1.142 mg/L PBTK NA 95% Rat Human +DTXSID5026209 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026209 Fup 0.0123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026209 Vd NA 0.6018 L/kg 1compartment NA NA Human Human +DTXSID5026209 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5026209 TK.Half.Life NA 8.04 hours 1compartment NA NA Human Human +DTXSID5026209 Css NA 2.317 mg/L 3compartmentss NA 50% Human Human +DTXSID5026209 Css NA 21.74 mg/L 3compartmentss NA 95% Human Human +DTXSID5026209 Css NA 1.376 mg/L PBTK NA 50% Human Human +DTXSID5026209 Css NA 12.81 mg/L PBTK NA 95% Human Human +DTXSID5026209 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026209 Fup 0.0123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026209 Vd NA 0.4541 L/kg 1compartment NA NA Rat Human +DTXSID5026209 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5026209 TK.Half.Life NA 3.874 hours 1compartment NA NA Rat Human +DTXSID5026209 Css NA 0.3005 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026209 Css NA 2.28 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026209 Css NA 0.1729 mg/L PBTK NA 50% Rat Human +DTXSID5026209 Css NA 1.288 mg/L PBTK NA 95% Rat Human +DTXSID5026251 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026251 Fup 0.0275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026251 Vd NA 3.118 L/kg 1compartment NA NA Human Human +DTXSID5026251 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID5026251 TK.Half.Life NA 86.87 hours 1compartment NA NA Human Human +DTXSID5026251 Css NA 3.262 mg/L 3compartmentss NA 50% Human Human +DTXSID5026251 Css NA 20.78 mg/L 3compartmentss NA 95% Human Human +DTXSID5026251 Css NA 2.271 mg/L PBTK NA 50% Human Human +DTXSID5026251 Css NA 13.99 mg/L PBTK NA 95% Human Human +DTXSID5026251 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026251 Fup 0.0275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026251 Vd NA 2.337 L/kg 1compartment NA NA Rat Human +DTXSID5026251 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID5026251 TK.Half.Life NA 11.74 hours 1compartment NA NA Rat Human +DTXSID5026251 Css NA 0.4267 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026251 Css NA 2.291 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026251 Css NA 0.2932 mg/L PBTK NA 50% Rat Human +DTXSID5026251 Css NA 1.551 mg/L PBTK NA 95% Rat Human +DTXSID5026259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026259 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026259 Vd NA 1.448 L/kg 1compartment NA NA Human Human DTXSID5026259 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5026259 TK.Half.Life NA 1.058 hours 1compartment NA NA Human Human -DTXSID5026259 Css NA 0.01671 mg/L 3compartmentss NA 50% Human Human -DTXSID5026259 Css NA 0.1305 mg/L 3compartmentss NA 95% Human Human -DTXSID5026259 Css NA 0.01052 mg/L PBTK NA 50% Human Human -DTXSID5026259 Css NA 0.07959 mg/L PBTK NA 95% Human Human -DTXSID5026259 Clint NA 622 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026259 Fup NA 0.0649 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026259 Vd NA 0.8272 L/kg 1compartment NA NA Rat Human +DTXSID5026259 TK.Half.Life NA 3.612 hours 1compartment NA NA Human Human +DTXSID5026259 Css NA 0.249 mg/L 3compartmentss NA 50% Human Human +DTXSID5026259 Css NA 1.901 mg/L 3compartmentss NA 95% Human Human +DTXSID5026259 Css NA 0.1672 mg/L PBTK NA 50% Human Human +DTXSID5026259 Css NA 1.205 mg/L PBTK NA 95% Human Human +DTXSID5026259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026259 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026259 Vd NA 1.118 L/kg 1compartment NA NA Rat Human DTXSID5026259 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5026259 TK.Half.Life NA 0.3693 hours 1compartment NA NA Rat Human -DTXSID5026259 Css NA 0.009497 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026259 Css NA 0.06287 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026259 Css NA 0.00568 mg/L PBTK NA 50% Rat Human -DTXSID5026259 Css NA 0.03642 mg/L PBTK NA 95% Rat Human -DTXSID5026544 Clint NA 0.2933 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026544 Fup NA 0.1722 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026544 Vd NA 0.4587 L/kg 1compartment NA NA Human Human -DTXSID5026544 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5026544 TK.Half.Life NA 11.69 hours 1compartment NA NA Human Human -DTXSID5026544 Css NA 3.046 mg/L 3compartmentss NA 50% Human Human -DTXSID5026544 Css NA 11.39 mg/L 3compartmentss NA 95% Human Human -DTXSID5026544 Css NA 2.015 mg/L PBTK NA 50% Human Human -DTXSID5026544 Css NA 6.859 mg/L PBTK NA 95% Human Human -DTXSID5026544 Clint NA 0.2933 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026544 Fup NA 0.1722 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026544 Vd NA 0.4329 L/kg 1compartment NA NA Rat Human +DTXSID5026259 TK.Half.Life NA 1.421 hours 1compartment NA NA Rat Human +DTXSID5026259 Css NA 0.03234 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026259 Css NA 0.1907 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026259 Css NA 0.0212 mg/L PBTK NA 50% Rat Human +DTXSID5026259 Css NA 0.117 mg/L PBTK NA 95% Rat Human +DTXSID5026544 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026544 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026544 Vd NA 0.6287 L/kg 1compartment NA NA Human Human +DTXSID5026544 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5026544 TK.Half.Life NA 0.8076 hours 1compartment NA NA Human Human +DTXSID5026544 Css NA 0.0649 mg/L 3compartmentss NA 50% Human Human +DTXSID5026544 Css NA 0.5179 mg/L 3compartmentss NA 95% Human Human +DTXSID5026544 Css NA 0.04658 mg/L PBTK NA 50% Human Human +DTXSID5026544 Css NA 0.3451 mg/L PBTK NA 95% Human Human +DTXSID5026544 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026544 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026544 Vd NA 0.5951 L/kg 1compartment NA NA Rat Human DTXSID5026544 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5026544 TK.Half.Life NA 4.489 hours 1compartment NA NA Rat Human -DTXSID5026544 Css NA 1.055 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026544 Css NA 3.171 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026544 Css NA 0.6562 mg/L PBTK NA 50% Rat Human -DTXSID5026544 Css NA 1.81 mg/L PBTK NA 95% Rat Human -DTXSID5026548 Clint NA 63.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026548 Fup NA 0.3 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026548 Vd NA 1.572 L/kg 1compartment NA NA Human Human -DTXSID5026548 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5026548 TK.Half.Life NA 1.304 hours 1compartment NA NA Human Human -DTXSID5026548 Css NA 0.02139 mg/L 3compartmentss NA 50% Human Human -DTXSID5026548 Css NA 0.1675 mg/L 3compartmentss NA 95% Human Human -DTXSID5026548 Css NA 0.018 mg/L PBTK NA 50% Human Human -DTXSID5026548 Css NA 0.1204 mg/L PBTK NA 95% Human Human -DTXSID5026548 Clint NA 63.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026548 Fup NA 0.3 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026548 Vd NA 1.578 L/kg 1compartment NA NA Rat Human +DTXSID5026544 TK.Half.Life NA 0.4028 hours 1compartment NA NA Rat Human +DTXSID5026544 Css NA 0.008232 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026544 Css NA 0.04776 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026544 Css NA 0.005835 mg/L PBTK NA 50% Rat Human +DTXSID5026544 Css NA 0.03104 mg/L PBTK NA 95% Rat Human +DTXSID5026548 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026548 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026548 Vd NA 1.736 L/kg 1compartment NA NA Human Human +DTXSID5026548 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5026548 TK.Half.Life NA 23.45 hours 1compartment NA NA Human Human +DTXSID5026548 Css NA 1.19 mg/L 3compartmentss NA 50% Human Human +DTXSID5026548 Css NA 6.479 mg/L 3compartmentss NA 95% Human Human +DTXSID5026548 Css NA 1.116 mg/L PBTK NA 50% Human Human +DTXSID5026548 Css NA 4.523 mg/L PBTK NA 95% Human Human +DTXSID5026548 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026548 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026548 Vd NA 1.752 L/kg 1compartment NA NA Rat Human DTXSID5026548 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5026548 TK.Half.Life NA 0.6436 hours 1compartment NA NA Rat Human -DTXSID5026548 Css NA 0.01132 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026548 Css NA 0.07264 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026548 Css NA 0.0093 mg/L PBTK NA 50% Rat Human -DTXSID5026548 Css NA 0.05249 mg/L PBTK NA 95% Rat Human -DTXSID5026623 Clint NA 0.4752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026623 Fup NA 0.215 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026623 Vd NA 2.651 L/kg 1compartment NA NA Human Human -DTXSID5026623 Days.Css NA 27 Days PBTK NA NA Human Human -DTXSID5026623 TK.Half.Life NA 141.1 hours 1compartment NA NA Human Human -DTXSID5026623 Css NA 5.907 mg/L 3compartmentss NA 50% Human Human -DTXSID5026623 Css NA 18.82 mg/L 3compartmentss NA 95% Human Human -DTXSID5026623 Css NA 4.306 mg/L PBTK NA 50% Human Human -DTXSID5026623 Css NA 12.75 mg/L PBTK NA 95% Human Human -DTXSID5026623 Clint NA 0.4752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026623 Fup NA 0.215 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026623 Vd NA 2.015 L/kg 1compartment NA NA Rat Human -DTXSID5026623 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID5026623 TK.Half.Life NA 22.25 hours 1compartment NA NA Rat Human -DTXSID5026623 Css NA 2.224 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026623 Css NA 5.339 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026623 Css NA 1.559 mg/L PBTK NA 50% Rat Human -DTXSID5026623 Css NA 3.316 mg/L PBTK NA 95% Rat Human -DTXSID5026625 Clint NA 3.588 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026625 Fup NA 0.2615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026625 Vd NA 2.502 L/kg 1compartment NA NA Human Human -DTXSID5026625 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5026625 TK.Half.Life NA 21.93 hours 1compartment NA NA Human Human -DTXSID5026625 Css NA 0.9572 mg/L 3compartmentss NA 50% Human Human -DTXSID5026625 Css NA 4.558 mg/L 3compartmentss NA 95% Human Human -DTXSID5026625 Css NA 0.7117 mg/L PBTK NA 50% Human Human -DTXSID5026625 Css NA 3.158 mg/L PBTK NA 95% Human Human -DTXSID5026625 Clint NA 3.588 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026625 Fup NA 0.2615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026625 Vd NA 1.917 L/kg 1compartment NA NA Rat Human -DTXSID5026625 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5026625 TK.Half.Life NA 5.369 hours 1compartment NA NA Rat Human -DTXSID5026625 Css NA 0.4756 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026625 Css NA 1.577 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026625 Css NA 0.3418 mg/L PBTK NA 50% Rat Human -DTXSID5026625 Css NA 1.04 mg/L PBTK NA 95% Rat Human -DTXSID5026702 Clint NA 303.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026702 Fup NA 0.5594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026702 Vd NA 0.9749 L/kg 1compartment NA NA Human Human -DTXSID5026702 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5026702 TK.Half.Life NA 0.64 hours 1compartment NA NA Human Human -DTXSID5026702 Css NA 0.00276 mg/L 3compartmentss NA 50% Human Human -DTXSID5026702 Css NA 0.03226 mg/L 3compartmentss NA 95% Human Human -DTXSID5026702 Css NA 0.002261 mg/L PBTK NA 50% Human Human -DTXSID5026702 Css NA 0.02201 mg/L PBTK NA 95% Human Human -DTXSID5026702 Clint NA 303.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026702 Fup NA 0.5594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026702 Vd NA 0.9081 L/kg 1compartment NA NA Rat Human +DTXSID5026548 TK.Half.Life NA 8.064 hours 1compartment NA NA Rat Human +DTXSID5026548 Css NA 0.07385 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026548 Css NA 0.368 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026548 Css NA 0.06938 mg/L PBTK NA 50% Rat Human +DTXSID5026548 Css NA 0.2454 mg/L PBTK NA 95% Rat Human +DTXSID5026625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026625 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026625 Vd NA 2.386 L/kg 1compartment NA NA Human Human +DTXSID5026625 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5026625 TK.Half.Life NA 5.594 hours 1compartment NA NA Human Human +DTXSID5026625 Css NA 0.1874 mg/L 3compartmentss NA 50% Human Human +DTXSID5026625 Css NA 1.197 mg/L 3compartmentss NA 95% Human Human +DTXSID5026625 Css NA 0.137 mg/L PBTK NA 50% Human Human +DTXSID5026625 Css NA 0.8301 mg/L PBTK NA 95% Human Human +DTXSID5026625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026625 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026625 Vd NA 1.826 L/kg 1compartment NA NA Rat Human +DTXSID5026625 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5026625 TK.Half.Life NA 1.651 hours 1compartment NA NA Rat Human +DTXSID5026625 Css NA 0.02362 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026625 Css NA 0.1186 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026625 Css NA 0.01716 mg/L PBTK NA 50% Rat Human +DTXSID5026625 Css NA 0.0834 mg/L PBTK NA 95% Rat Human +DTXSID5026702 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026702 Fup 0.45 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026702 Vd NA 0.6983 L/kg 1compartment NA NA Human Human +DTXSID5026702 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5026702 TK.Half.Life NA 10.16 hours 1compartment NA NA Human Human +DTXSID5026702 Css NA 1.519 mg/L 3compartmentss NA 50% Human Human +DTXSID5026702 Css NA 7.363 mg/L 3compartmentss NA 95% Human Human +DTXSID5026702 Css NA 1.172 mg/L PBTK NA 50% Human Human +DTXSID5026702 Css NA 4.761 mg/L PBTK NA 95% Human Human +DTXSID5026702 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026702 Fup 0.45 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026702 Vd NA 0.6794 L/kg 1compartment NA NA Rat Human DTXSID5026702 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5026702 TK.Half.Life NA 0.2614 hours 1compartment NA NA Rat Human -DTXSID5026702 Css NA 0.001475 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026702 Css NA 0.01498 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026702 Css NA 0.00117 mg/L PBTK NA 50% Rat Human -DTXSID5026702 Css NA 0.009928 mg/L PBTK NA 95% Rat Human +DTXSID5026702 TK.Half.Life NA 3.337 hours 1compartment NA NA Rat Human +DTXSID5026702 Css NA 0.09712 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026702 Css NA 0.3967 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026702 Css NA 0.07417 mg/L PBTK NA 50% Rat Human +DTXSID5026702 Css NA 0.246 mg/L PBTK NA 95% Rat Human DTXSID5026706 Clint 18.51 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID5026706 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID5026706 Clint 18.51 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID5026706 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID5026881 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026881 Fup NA 0.0126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026881 Vd NA 45.97 L/kg 1compartment NA NA Human Human -DTXSID5026881 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID5026881 TK.Half.Life NA 2159000 hours 1compartment NA NA Human Human -DTXSID5026881 Css NA 723.4 mg/L 3compartmentss NA 50% Human Human -DTXSID5026881 Css NA 1876 mg/L 3compartmentss NA 95% Human Human -DTXSID5026881 Css NA 3640 mg/L PBTK NA 50% Human Human -DTXSID5026881 Css NA 7840 mg/L PBTK NA 95% Human Human -DTXSID5026881 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026881 Fup NA 0.0126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026881 Vd NA 38.63 L/kg 1compartment NA NA Rat Human -DTXSID5026881 Days.Css NA 13780 Days PBTK NA NA Rat Human -DTXSID5026881 TK.Half.Life NA 152600 hours 1compartment NA NA Rat Human -DTXSID5026881 Css NA 178 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026881 Css NA 319.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026881 Css NA 972.4 mg/L PBTK NA 50% Rat Human -DTXSID5026881 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID5026912 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026912 Fup NA 0.8857 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026912 Vd NA 1.024 L/kg 1compartment NA NA Human Human +DTXSID5026881 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026881 Fup 0.0155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026881 Vd NA 7.093 L/kg 1compartment NA NA Human Human +DTXSID5026881 Days.Css NA 41 Days PBTK NA NA Human Human +DTXSID5026881 TK.Half.Life NA 212.6 hours 1compartment NA NA Human Human +DTXSID5026881 Css NA 1.359 mg/L 3compartmentss NA 50% Human Human +DTXSID5026881 Css NA 8.996 mg/L 3compartmentss NA 95% Human Human +DTXSID5026881 Css NA 1.312 mg/L PBTK NA 50% Human Human +DTXSID5026881 Css NA 8.284 mg/L PBTK NA 95% Human Human +DTXSID5026881 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026881 Fup 0.0155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026881 Vd NA 5.499 L/kg 1compartment NA NA Rat Human +DTXSID5026881 Days.Css NA 24 Days PBTK NA NA Rat Human +DTXSID5026881 TK.Half.Life NA 29.19 hours 1compartment NA NA Rat Human +DTXSID5026881 Css NA 0.01438 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026881 Css NA 0.08918 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026881 Css NA 0.01366 mg/L PBTK NA 50% Rat Human +DTXSID5026881 Css NA 0.08346 mg/L PBTK NA 95% Rat Human +DTXSID5026912 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026912 Fup 0.66 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026912 Vd NA 0.6803 L/kg 1compartment NA NA Human Human DTXSID5026912 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5026912 TK.Half.Life NA 7.518 hours 1compartment NA NA Human Human -DTXSID5026912 Css NA 0.8953 mg/L 3compartmentss NA 50% Human Human -DTXSID5026912 Css NA 5.03 mg/L 3compartmentss NA 95% Human Human -DTXSID5026912 Css NA 0.7784 mg/L PBTK NA 50% Human Human -DTXSID5026912 Css NA 3.351 mg/L PBTK NA 95% Human Human -DTXSID5026912 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026912 Fup NA 0.8857 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026912 Vd NA 1.038 L/kg 1compartment NA NA Rat Human +DTXSID5026912 TK.Half.Life NA 6.671 hours 1compartment NA NA Human Human +DTXSID5026912 Css NA 0.9754 mg/L 3compartmentss NA 50% Human Human +DTXSID5026912 Css NA 6.319 mg/L 3compartmentss NA 95% Human Human +DTXSID5026912 Css NA 0.7804 mg/L PBTK NA 50% Human Human +DTXSID5026912 Css NA 4.041 mg/L PBTK NA 95% Human Human +DTXSID5026912 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026912 Fup 0.66 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026912 Vd NA 0.7086 L/kg 1compartment NA NA Rat Human DTXSID5026912 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5026912 TK.Half.Life NA 2.587 hours 1compartment NA NA Rat Human -DTXSID5026912 Css NA 0.225 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026912 Css NA 1.354 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026912 Css NA 0.1914 mg/L PBTK NA 50% Rat Human -DTXSID5026912 Css NA 0.8284 mg/L PBTK NA 95% Rat Human -DTXSID5026918 Clint NA 30.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026918 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5026918 Vd NA 3.1 L/kg 1compartment NA NA Human Human -DTXSID5026918 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID5026918 TK.Half.Life NA 47.8 hours 1compartment NA NA Human Human -DTXSID5026918 Css NA 1.819 mg/L 3compartmentss NA 50% Human Human -DTXSID5026918 Css NA 12.11 mg/L 3compartmentss NA 95% Human Human -DTXSID5026918 Css NA 1.263 mg/L PBTK NA 50% Human Human -DTXSID5026918 Css NA 8.166 mg/L PBTK NA 95% Human Human -DTXSID5026918 Clint NA 30.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026918 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5026918 Vd NA 2.323 L/kg 1compartment NA NA Rat Human -DTXSID5026918 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5026918 TK.Half.Life NA 6.863 hours 1compartment NA NA Rat Human -DTXSID5026918 Css NA 1.033 mg/L 3compartmentss NA 50% Rat Human -DTXSID5026918 Css NA 5.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID5026918 Css NA 0.6849 mg/L PBTK NA 50% Rat Human -DTXSID5026918 Css NA 3.512 mg/L PBTK NA 95% Rat Human -DTXSID5027019 Clint NA 0.4105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027019 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027019 Vd NA 5.943 L/kg 1compartment NA NA Human Human -DTXSID5027019 Days.Css NA 2439 Days PBTK NA NA Human Human -DTXSID5027019 TK.Half.Life NA 8944 hours 1compartment NA NA Human Human -DTXSID5027019 Css NA 143 mg/L 3compartmentss NA 50% Human Human -DTXSID5027019 Css NA 716.9 mg/L 3compartmentss NA 95% Human Human -DTXSID5027019 Css NA 125 mg/L PBTK NA 50% Human Human -DTXSID5027019 Css NA 611.4 mg/L PBTK NA 95% Human Human -DTXSID5027019 Clint NA 0.4105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027019 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027019 Vd NA 4.572 L/kg 1compartment NA NA Rat Human -DTXSID5027019 Days.Css NA 1279 Days PBTK NA NA Rat Human -DTXSID5027019 TK.Half.Life NA 1140 hours 1compartment NA NA Rat Human -DTXSID5027019 Css NA 75.82 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027019 Css NA 266 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027019 Css NA 64.93 mg/L PBTK NA 50% Rat Human -DTXSID5027019 Css NA 224.6 mg/L PBTK NA 95% Rat Human +DTXSID5026912 TK.Half.Life NA 2.367 hours 1compartment NA NA Rat Human +DTXSID5026912 Css NA 0.0188 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026912 Css NA 0.1542 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026912 Css NA 0.01436 mg/L PBTK NA 50% Rat Human +DTXSID5026912 Css NA 0.09701 mg/L PBTK NA 95% Rat Human +DTXSID5026918 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026918 Fup 0.0275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5026918 Vd NA 3.068 L/kg 1compartment NA NA Human Human +DTXSID5026918 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID5026918 TK.Half.Life NA 67.1 hours 1compartment NA NA Human Human +DTXSID5026918 Css NA 2.619 mg/L 3compartmentss NA 50% Human Human +DTXSID5026918 Css NA 17.21 mg/L 3compartmentss NA 95% Human Human +DTXSID5026918 Css NA 1.808 mg/L PBTK NA 50% Human Human +DTXSID5026918 Css NA 11.62 mg/L PBTK NA 95% Human Human +DTXSID5026918 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026918 Fup 0.0275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5026918 Vd NA 2.298 L/kg 1compartment NA NA Rat Human +DTXSID5026918 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID5026918 TK.Half.Life NA 9.808 hours 1compartment NA NA Rat Human +DTXSID5026918 Css NA 0.3426 mg/L 3compartmentss NA 50% Rat Human +DTXSID5026918 Css NA 1.999 mg/L 3compartmentss NA 95% Rat Human +DTXSID5026918 Css NA 0.2334 mg/L PBTK NA 50% Rat Human +DTXSID5026918 Css NA 1.306 mg/L PBTK NA 95% Rat Human DTXSID5027061 Clint 119 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5027061 Fup 0.0513 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID5027061 Vd NA 0.8118 L/kg 1compartment NA NA Rat Rat DTXSID5027061 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID5027061 TK.Half.Life NA 0.6448 hours 1compartment NA NA Rat Rat -DTXSID5027061 Css NA 0.06437 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5027061 Css NA 0.4505 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5027061 Css NA 0.03788 mg/L PBTK NA 50% Rat Rat -DTXSID5027061 Css NA 0.2577 mg/L PBTK NA 95% Rat Rat -DTXSID5027063 Clint NA 0.1736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027063 Fup NA 0.1972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027063 Vd NA 0.4442 L/kg 1compartment NA NA Human Human -DTXSID5027063 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5027063 TK.Half.Life NA 11.36 hours 1compartment NA NA Human Human -DTXSID5027063 Css NA 2.971 mg/L 3compartmentss NA 50% Human Human -DTXSID5027063 Css NA 11.38 mg/L 3compartmentss NA 95% Human Human -DTXSID5027063 Css NA 2.052 mg/L PBTK NA 50% Human Human -DTXSID5027063 Css NA 7.104 mg/L PBTK NA 95% Human Human -DTXSID5027063 Clint NA 0.1736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027063 Fup NA 0.1972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027063 Vd NA 0.4322 L/kg 1compartment NA NA Rat Human +DTXSID5027061 Css NA 0.01417 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5027061 Css NA 0.1028 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5027061 Css NA 0.008644 mg/L PBTK NA 50% Rat Rat +DTXSID5027061 Css NA 0.06029 mg/L PBTK NA 95% Rat Rat +DTXSID5027063 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027063 Fup 0.456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027063 Vd NA 0.3993 L/kg 1compartment NA NA Human Human +DTXSID5027063 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5027063 TK.Half.Life NA 5.663 hours 1compartment NA NA Human Human +DTXSID5027063 Css NA 1.631 mg/L 3compartmentss NA 50% Human Human +DTXSID5027063 Css NA 7.384 mg/L 3compartmentss NA 95% Human Human +DTXSID5027063 Css NA 1.154 mg/L PBTK NA 50% Human Human +DTXSID5027063 Css NA 4.599 mg/L PBTK NA 95% Human Human +DTXSID5027063 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027063 Fup 0.456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027063 Vd NA 0.4078 L/kg 1compartment NA NA Rat Human DTXSID5027063 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027063 TK.Half.Life NA 4.242 hours 1compartment NA NA Rat Human -DTXSID5027063 Css NA 0.9512 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027063 Css NA 2.977 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027063 Css NA 0.623 mg/L PBTK NA 50% Rat Human -DTXSID5027063 Css NA 1.731 mg/L PBTK NA 95% Rat Human -DTXSID5027069 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027069 Fup NA 0.8246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027069 Vd NA 1.434 L/kg 1compartment NA NA Human Human -DTXSID5027069 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5027069 TK.Half.Life NA 12.57 hours 1compartment NA NA Human Human -DTXSID5027069 Css NA 0.9184 mg/L 3compartmentss NA 50% Human Human -DTXSID5027069 Css NA 5.639 mg/L 3compartmentss NA 95% Human Human -DTXSID5027069 Css NA 0.846 mg/L PBTK NA 50% Human Human -DTXSID5027069 Css NA 3.833 mg/L PBTK NA 95% Human Human -DTXSID5027069 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027069 Fup NA 0.8246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027069 Vd NA 1.296 L/kg 1compartment NA NA Rat Human +DTXSID5027063 TK.Half.Life NA 1.971 hours 1compartment NA NA Rat Human +DTXSID5027063 Css NA 0.1042 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027063 Css NA 0.3985 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027063 Css NA 0.07245 mg/L PBTK NA 50% Rat Human +DTXSID5027063 Css NA 0.2393 mg/L PBTK NA 95% Rat Human +DTXSID5027069 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027069 Fup 0.539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027069 Vd NA 1.122 L/kg 1compartment NA NA Human Human +DTXSID5027069 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5027069 TK.Half.Life NA 1.057 hours 1compartment NA NA Human Human +DTXSID5027069 Css NA 0.02898 mg/L 3compartmentss NA 50% Human Human +DTXSID5027069 Css NA 0.3081 mg/L 3compartmentss NA 95% Human Human +DTXSID5027069 Css NA 0.02382 mg/L PBTK NA 50% Human Human +DTXSID5027069 Css NA 0.2167 mg/L PBTK NA 95% Human Human +DTXSID5027069 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027069 Fup 0.539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027069 Vd NA 1.01 L/kg 1compartment NA NA Rat Human DTXSID5027069 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027069 TK.Half.Life NA 3.562 hours 1compartment NA NA Rat Human -DTXSID5027069 Css NA 0.2342 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027069 Css NA 1.429 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027069 Css NA 0.2114 mg/L PBTK NA 50% Rat Human -DTXSID5027069 Css NA 0.8943 mg/L PBTK NA 95% Rat Human -DTXSID5027198 Clint NA 139.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027198 Fup NA 0.6995 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027198 Vd NA 1.32 L/kg 1compartment NA NA Human Human +DTXSID5027069 TK.Half.Life NA 0.4709 hours 1compartment NA NA Rat Human +DTXSID5027069 Css NA 0.001013 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027069 Css NA 0.01272 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027069 Css NA 0.0008333 mg/L PBTK NA 50% Rat Human +DTXSID5027069 Css NA 0.008672 mg/L PBTK NA 95% Rat Human +DTXSID5027192 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027192 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027192 Vd NA 2.724 L/kg 1compartment NA NA Human Human +DTXSID5027192 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5027192 TK.Half.Life NA 10.76 hours 1compartment NA NA Human Human +DTXSID5027192 Css NA 0.3896 mg/L 3compartmentss NA 50% Human Human +DTXSID5027192 Css NA 2.635 mg/L 3compartmentss NA 95% Human Human +DTXSID5027192 Css NA 0.2762 mg/L PBTK NA 50% Human Human +DTXSID5027192 Css NA 1.801 mg/L PBTK NA 95% Human Human +DTXSID5027192 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027192 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027192 Vd NA 2.059 L/kg 1compartment NA NA Rat Human +DTXSID5027192 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5027192 TK.Half.Life NA 2.515 hours 1compartment NA NA Rat Human +DTXSID5027192 Css NA 0.04976 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027192 Css NA 0.2504 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027192 Css NA 0.03514 mg/L PBTK NA 50% Rat Human +DTXSID5027192 Css NA 0.1701 mg/L PBTK NA 95% Rat Human +DTXSID5027198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027198 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027198 Vd NA 0.7324 L/kg 1compartment NA NA Human Human DTXSID5027198 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027198 TK.Half.Life NA 0.8112 hours 1compartment NA NA Human Human -DTXSID5027198 Css NA 0.00483 mg/L 3compartmentss NA 50% Human Human -DTXSID5027198 Css NA 0.0548 mg/L 3compartmentss NA 95% Human Human -DTXSID5027198 Css NA 0.004244 mg/L PBTK NA 50% Human Human -DTXSID5027198 Css NA 0.03908 mg/L PBTK NA 95% Human Human -DTXSID5027198 Clint NA 139.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027198 Fup NA 0.6995 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027198 Vd NA 1.188 L/kg 1compartment NA NA Rat Human +DTXSID5027198 TK.Half.Life NA 1.062 hours 1compartment NA NA Human Human +DTXSID5027198 Css NA 0.08224 mg/L 3compartmentss NA 50% Human Human +DTXSID5027198 Css NA 0.6337 mg/L 3compartmentss NA 95% Human Human +DTXSID5027198 Css NA 0.05806 mg/L PBTK NA 50% Human Human +DTXSID5027198 Css NA 0.4109 mg/L PBTK NA 95% Human Human +DTXSID5027198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027198 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027198 Vd NA 0.6531 L/kg 1compartment NA NA Rat Human DTXSID5027198 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027198 TK.Half.Life NA 0.3221 hours 1compartment NA NA Rat Human -DTXSID5027198 Css NA 0.002528 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027198 Css NA 0.02558 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027198 Css NA 0.002184 mg/L PBTK NA 50% Rat Human -DTXSID5027198 Css NA 0.01778 mg/L PBTK NA 95% Rat Human +DTXSID5027198 TK.Half.Life NA 0.5071 hours 1compartment NA NA Rat Human +DTXSID5027198 Css NA 0.01063 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027198 Css NA 0.05861 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027198 Css NA 0.007402 mg/L PBTK NA 50% Rat Human +DTXSID5027198 Css NA 0.03798 mg/L PBTK NA 95% Rat Human DTXSID5027279 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5027279 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027279 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID5027279 Vd NA 0.328 L/kg 1compartment NA NA Human Human DTXSID5027279 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027279 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID5027279 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID5027279 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID5027279 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID5027279 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID5027279 TK.Half.Life NA 6.57 hours 1compartment NA NA Human Human +DTXSID5027279 Css NA 2.057 mg/L 3compartmentss NA 50% Human Human +DTXSID5027279 Css NA 8.591 mg/L 3compartmentss NA 95% Human Human +DTXSID5027279 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID5027279 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID5027279 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5027279 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027279 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID5027279 Vd NA 0.3456 L/kg 1compartment NA NA Rat Human DTXSID5027279 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027279 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID5027279 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027279 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027279 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID5027279 Css NA 1.313 mg/L PBTK NA 95% Rat Human +DTXSID5027279 TK.Half.Life NA 2.358 hours 1compartment NA NA Rat Human +DTXSID5027279 Css NA 0.03854 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027279 Css NA 0.2272 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027279 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID5027279 Css NA 0.1369 mg/L PBTK NA 95% Rat Human DTXSID5027300 Clint NA 3.269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5027300 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5027300 Vd NA 1.353 L/kg 1compartment NA NA Human Human DTXSID5027300 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5027300 TK.Half.Life NA 1.93 hours 1compartment NA NA Human Human -DTXSID5027300 Css NA 0.1212 mg/L 3compartmentss NA 50% Human Human -DTXSID5027300 Css NA 1.115 mg/L 3compartmentss NA 95% Human Human -DTXSID5027300 Css NA 0.1127 mg/L PBTK NA 50% Human Human -DTXSID5027300 Css NA 0.8217 mg/L PBTK NA 95% Human Human +DTXSID5027300 Css NA 0.09998 mg/L 3compartmentss NA 50% Human Human +DTXSID5027300 Css NA 0.9092 mg/L 3compartmentss NA 95% Human Human +DTXSID5027300 Css NA 0.09226 mg/L PBTK NA 50% Human Human +DTXSID5027300 Css NA 0.6648 mg/L PBTK NA 95% Human Human DTXSID5027300 Clint NA 3.269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5027300 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5027300 Vd NA 1.272 L/kg 1compartment NA NA Rat Human DTXSID5027300 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5027300 TK.Half.Life NA 0.9251 hours 1compartment NA NA Rat Human -DTXSID5027300 Css NA 0.05347 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027300 Css NA 0.4005 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027300 Css NA 0.04996 mg/L PBTK NA 50% Rat Human -DTXSID5027300 Css NA 0.2553 mg/L PBTK NA 95% Rat Human +DTXSID5027300 Css NA 0.003033 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027300 Css NA 0.03211 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027300 Css NA 0.002816 mg/L PBTK NA 50% Rat Human +DTXSID5027300 Css NA 0.02291 mg/L PBTK NA 95% Rat Human DTXSID5027302 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5027302 Fup NA 0.0307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027302 Vd NA 1.788 L/kg 1compartment NA NA Human Human -DTXSID5027302 Days.Css NA 157 Days PBTK NA NA Human Human -DTXSID5027302 TK.Half.Life NA 631.9 hours 1compartment NA NA Human Human -DTXSID5027302 Css NA 52.92 mg/L 3compartmentss NA 50% Human Human -DTXSID5027302 Css NA 246.3 mg/L 3compartmentss NA 95% Human Human -DTXSID5027302 Css NA 33.91 mg/L PBTK NA 50% Human Human -DTXSID5027302 Css NA 147.3 mg/L PBTK NA 95% Human Human +DTXSID5027302 Vd NA 1.877 L/kg 1compartment NA NA Human Human +DTXSID5027302 Days.Css NA 176 Days PBTK NA NA Human Human +DTXSID5027302 TK.Half.Life NA 703.3 hours 1compartment NA NA Human Human +DTXSID5027302 Css NA 54.27 mg/L 3compartmentss NA 50% Human Human +DTXSID5027302 Css NA 252.7 mg/L 3compartmentss NA 95% Human Human +DTXSID5027302 Css NA 34.95 mg/L PBTK NA 50% Human Human +DTXSID5027302 Css NA 152.8 mg/L PBTK NA 95% Human Human DTXSID5027302 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5027302 Fup NA 0.0307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027302 Vd NA 1.333 L/kg 1compartment NA NA Rat Human -DTXSID5027302 Days.Css NA 37 Days PBTK NA NA Rat Human -DTXSID5027302 TK.Half.Life NA 111.2 hours 1compartment NA NA Rat Human -DTXSID5027302 Css NA 14.83 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027302 Css NA 59.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027302 Css NA 8.931 mg/L PBTK NA 50% Rat Human -DTXSID5027302 Css NA 33.18 mg/L PBTK NA 95% Rat Human -DTXSID5027304 Clint NA 0.03329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027304 Fup NA 0.2308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027304 Vd NA 3.09 L/kg 1compartment NA NA Human Human -DTXSID5027304 Days.Css NA 578 Days PBTK NA NA Human Human -DTXSID5027304 TK.Half.Life NA 2195 hours 1compartment NA NA Human Human -DTXSID5027304 Css NA 78.34 mg/L 3compartmentss NA 50% Human Human -DTXSID5027304 Css NA 215.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5027304 Css NA 55.6 mg/L PBTK NA 50% Human Human -DTXSID5027304 Css NA 142 mg/L PBTK NA 95% Human Human -DTXSID5027304 Clint NA 0.03329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027304 Fup NA 0.2308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027304 Vd NA 2.323 L/kg 1compartment NA NA Rat Human -DTXSID5027304 Days.Css NA 157 Days PBTK NA NA Rat Human -DTXSID5027304 TK.Half.Life NA 159.1 hours 1compartment NA NA Rat Human -DTXSID5027304 Css NA 23.06 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027304 Css NA 50.11 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027304 Css NA 15.64 mg/L PBTK NA 50% Rat Human -DTXSID5027304 Css NA 30.6 mg/L PBTK NA 95% Rat Human -DTXSID5027356 Clint NA 77.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027356 Fup NA 0.1793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027356 Vd NA 0.3793 L/kg 1compartment NA NA Human Human -DTXSID5027356 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027356 TK.Half.Life NA 0.426 hours 1compartment NA NA Human Human -DTXSID5027356 Css NA 0.03766 mg/L 3compartmentss NA 50% Human Human -DTXSID5027356 Css NA 0.273 mg/L 3compartmentss NA 95% Human Human -DTXSID5027356 Css NA 0.02467 mg/L PBTK NA 50% Human Human -DTXSID5027356 Css NA 0.1701 mg/L PBTK NA 95% Human Human -DTXSID5027356 Clint NA 77.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027356 Fup NA 0.1793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027356 Vd NA 0.3766 L/kg 1compartment NA NA Rat Human +DTXSID5027302 Vd NA 1.398 L/kg 1compartment NA NA Rat Human +DTXSID5027302 Days.Css NA 41 Days PBTK NA NA Rat Human +DTXSID5027302 TK.Half.Life NA 119 hours 1compartment NA NA Rat Human +DTXSID5027302 Css NA 3.453 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027302 Css NA 13.46 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027302 Css NA 2.168 mg/L PBTK NA 50% Rat Human +DTXSID5027302 Css NA 7.788 mg/L PBTK NA 95% Rat Human +DTXSID5027308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027308 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027308 Vd NA 2.037 L/kg 1compartment NA NA Human Human +DTXSID5027308 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5027308 TK.Half.Life NA 5.169 hours 1compartment NA NA Human Human +DTXSID5027308 Css NA 0.2388 mg/L 3compartmentss NA 50% Human Human +DTXSID5027308 Css NA 1.599 mg/L 3compartmentss NA 95% Human Human +DTXSID5027308 Css NA 0.1664 mg/L PBTK NA 50% Human Human +DTXSID5027308 Css NA 1.062 mg/L PBTK NA 95% Human Human +DTXSID5027308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027308 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027308 Vd NA 1.556 L/kg 1compartment NA NA Rat Human +DTXSID5027308 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5027308 TK.Half.Life NA 1.719 hours 1compartment NA NA Rat Human +DTXSID5027308 Css NA 0.03042 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027308 Css NA 0.1692 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027308 Css NA 0.02095 mg/L PBTK NA 50% Rat Human +DTXSID5027308 Css NA 0.112 mg/L PBTK NA 95% Rat Human +DTXSID5027356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027356 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027356 Vd NA 0.9365 L/kg 1compartment NA NA Human Human +DTXSID5027356 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5027356 TK.Half.Life NA 16.24 hours 1compartment NA NA Human Human +DTXSID5027356 Css NA 1.794 mg/L 3compartmentss NA 50% Human Human +DTXSID5027356 Css NA 7.848 mg/L 3compartmentss NA 95% Human Human +DTXSID5027356 Css NA 1.396 mg/L PBTK NA 50% Human Human +DTXSID5027356 Css NA 5.128 mg/L PBTK NA 95% Human Human +DTXSID5027356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027356 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027356 Vd NA 0.8404 L/kg 1compartment NA NA Rat Human DTXSID5027356 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027356 TK.Half.Life NA 0.2095 hours 1compartment NA NA Rat Human -DTXSID5027356 Css NA 0.0209 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027356 Css NA 0.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027356 Css NA 0.01288 mg/L PBTK NA 50% Rat Human -DTXSID5027356 Css NA 0.0715 mg/L PBTK NA 95% Rat Human -DTXSID5027358 Clint NA 0.04196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027358 Fup NA 0.3132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027358 Vd NA 0.4814 L/kg 1compartment NA NA Human Human +DTXSID5027356 TK.Half.Life NA 4.767 hours 1compartment NA NA Rat Human +DTXSID5027356 Css NA 0.1144 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027356 Css NA 0.426 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027356 Css NA 0.08799 mg/L PBTK NA 50% Rat Human +DTXSID5027356 Css NA 0.2679 mg/L PBTK NA 95% Rat Human +DTXSID5027358 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027358 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027358 Vd NA 0.9559 L/kg 1compartment NA NA Human Human DTXSID5027358 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027358 TK.Half.Life NA 9.371 hours 1compartment NA NA Human Human -DTXSID5027358 Css NA 2.267 mg/L 3compartmentss NA 50% Human Human -DTXSID5027358 Css NA 9.237 mg/L 3compartmentss NA 95% Human Human -DTXSID5027358 Css NA 1.574 mg/L PBTK NA 50% Human Human -DTXSID5027358 Css NA 5.733 mg/L PBTK NA 95% Human Human -DTXSID5027358 Clint NA 0.04196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027358 Fup NA 0.3132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027358 Vd NA 0.4599 L/kg 1compartment NA NA Rat Human +DTXSID5027358 TK.Half.Life NA 1.207 hours 1compartment NA NA Human Human +DTXSID5027358 Css NA 0.06271 mg/L 3compartmentss NA 50% Human Human +DTXSID5027358 Css NA 0.483 mg/L 3compartmentss NA 95% Human Human +DTXSID5027358 Css NA 0.04617 mg/L PBTK NA 50% Human Human +DTXSID5027358 Css NA 0.328 mg/L PBTK NA 95% Human Human +DTXSID5027358 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027358 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027358 Vd NA 0.833 L/kg 1compartment NA NA Rat Human DTXSID5027358 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027358 TK.Half.Life NA 3.138 hours 1compartment NA NA Rat Human -DTXSID5027358 Css NA 0.6592 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027358 Css NA 2.222 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027358 Css NA 0.432 mg/L PBTK NA 50% Rat Human -DTXSID5027358 Css NA 1.286 mg/L PBTK NA 95% Rat Human -DTXSID5027433 Clint NA 348.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027433 Fup NA 0.7926 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027433 Vd NA 3.22 L/kg 1compartment NA NA Human Human -DTXSID5027433 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027433 TK.Half.Life NA 1.318 hours 1compartment NA NA Human Human -DTXSID5027433 Css NA 0.0013 mg/L 3compartmentss NA 50% Human Human -DTXSID5027433 Css NA 0.01662 mg/L 3compartmentss NA 95% Human Human -DTXSID5027433 Css NA 0.001518 mg/L PBTK NA 50% Human Human -DTXSID5027433 Css NA 0.01443 mg/L PBTK NA 95% Human Human -DTXSID5027433 Clint NA 348.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027433 Fup NA 0.7926 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027433 Vd NA 3.279 L/kg 1compartment NA NA Rat Human -DTXSID5027433 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027433 TK.Half.Life NA 0.5909 hours 1compartment NA NA Rat Human -DTXSID5027433 Css NA 0.0006536 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027433 Css NA 0.008028 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027433 Css NA 0.0007876 mg/L PBTK NA 50% Rat Human -DTXSID5027433 Css NA 0.006795 mg/L PBTK NA 95% Rat Human -DTXSID5027487 Clint NA 35.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027487 Fup NA 0.2835 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027487 Vd NA 0.9435 L/kg 1compartment NA NA Human Human -DTXSID5027487 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027487 TK.Half.Life NA 1.061 hours 1compartment NA NA Human Human -DTXSID5027487 Css NA 0.04756 mg/L 3compartmentss NA 50% Human Human -DTXSID5027487 Css NA 0.3625 mg/L 3compartmentss NA 95% Human Human -DTXSID5027487 Css NA 0.03474 mg/L PBTK NA 50% Human Human -DTXSID5027487 Css NA 0.2487 mg/L PBTK NA 95% Human Human -DTXSID5027487 Clint NA 35.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027487 Fup NA 0.2835 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027487 Vd NA 0.8137 L/kg 1compartment NA NA Rat Human +DTXSID5027358 TK.Half.Life NA 0.5441 hours 1compartment NA NA Rat Human +DTXSID5027358 Css NA 0.007946 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027358 Css NA 0.04575 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027358 Css NA 0.005888 mg/L PBTK NA 50% Rat Human +DTXSID5027358 Css NA 0.03046 mg/L PBTK NA 95% Rat Human +DTXSID5027433 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027433 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027433 Vd NA 2.647 L/kg 1compartment NA NA Human Human +DTXSID5027433 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5027433 TK.Half.Life NA 29.2 hours 1compartment NA NA Human Human +DTXSID5027433 Css NA 0.8898 mg/L 3compartmentss NA 50% Human Human +DTXSID5027433 Css NA 7.596 mg/L 3compartmentss NA 95% Human Human +DTXSID5027433 Css NA 0.9752 mg/L PBTK NA 50% Human Human +DTXSID5027433 Css NA 5.218 mg/L PBTK NA 95% Human Human +DTXSID5027433 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027433 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027433 Vd NA 2.686 L/kg 1compartment NA NA Rat Human +DTXSID5027433 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5027433 TK.Half.Life NA 10.07 hours 1compartment NA NA Rat Human +DTXSID5027433 Css NA 0.05268 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027433 Css NA 0.4199 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027433 Css NA 0.0592 mg/L PBTK NA 50% Rat Human +DTXSID5027433 Css NA 0.2845 mg/L PBTK NA 95% Rat Human +DTXSID5027487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027487 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027487 Vd NA 0.6857 L/kg 1compartment NA NA Human Human +DTXSID5027487 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5027487 TK.Half.Life NA 11.48 hours 1compartment NA NA Human Human +DTXSID5027487 Css NA 1.786 mg/L 3compartmentss NA 50% Human Human +DTXSID5027487 Css NA 7.666 mg/L 3compartmentss NA 95% Human Human +DTXSID5027487 Css NA 1.342 mg/L PBTK NA 50% Human Human +DTXSID5027487 Css NA 4.979 mg/L PBTK NA 95% Human Human +DTXSID5027487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027487 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027487 Vd NA 0.6574 L/kg 1compartment NA NA Rat Human DTXSID5027487 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027487 TK.Half.Life NA 0.4596 hours 1compartment NA NA Rat Human -DTXSID5027487 Css NA 0.02624 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027487 Css NA 0.1488 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027487 Css NA 0.01839 mg/L PBTK NA 50% Rat Human -DTXSID5027487 Css NA 0.09888 mg/L PBTK NA 95% Rat Human -DTXSID5027489 Clint NA 99.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027489 Fup NA 0.3155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027489 Vd NA 0.8527 L/kg 1compartment NA NA Human Human +DTXSID5027487 TK.Half.Life NA 3.711 hours 1compartment NA NA Rat Human +DTXSID5027487 Css NA 0.1134 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027487 Css NA 0.4143 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027487 Css NA 0.0844 mg/L PBTK NA 50% Rat Human +DTXSID5027487 Css NA 0.2571 mg/L PBTK NA 95% Rat Human +DTXSID5027489 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027489 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027489 Vd NA 1.544 L/kg 1compartment NA NA Human Human DTXSID5027489 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027489 TK.Half.Life NA 0.7299 hours 1compartment NA NA Human Human -DTXSID5027489 Css NA 0.01505 mg/L 3compartmentss NA 50% Human Human -DTXSID5027489 Css NA 0.119 mg/L 3compartmentss NA 95% Human Human -DTXSID5027489 Css NA 0.01108 mg/L PBTK NA 50% Human Human -DTXSID5027489 Css NA 0.08242 mg/L PBTK NA 95% Human Human -DTXSID5027489 Clint NA 99.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027489 Fup NA 0.3155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027489 Vd NA 0.7587 L/kg 1compartment NA NA Rat Human +DTXSID5027489 TK.Half.Life NA 1.865 hours 1compartment NA NA Human Human +DTXSID5027489 Css NA 0.0582 mg/L 3compartmentss NA 50% Human Human +DTXSID5027489 Css NA 0.4617 mg/L 3compartmentss NA 95% Human Human +DTXSID5027489 Css NA 0.04598 mg/L PBTK NA 50% Human Human +DTXSID5027489 Css NA 0.3286 mg/L PBTK NA 95% Human Human +DTXSID5027489 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027489 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027489 Vd NA 1.266 L/kg 1compartment NA NA Rat Human DTXSID5027489 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027489 TK.Half.Life NA 0.3018 hours 1compartment NA NA Rat Human -DTXSID5027489 Css NA 0.008325 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027489 Css NA 0.0523 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027489 Css NA 0.005884 mg/L PBTK NA 50% Rat Human -DTXSID5027489 Css NA 0.03367 mg/L PBTK NA 95% Rat Human -DTXSID5027512 Clint NA 4.897 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027512 Fup NA 0.6809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027512 Vd NA 2.178 L/kg 1compartment NA NA Human Human -DTXSID5027512 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027512 TK.Half.Life NA 3.103 hours 1compartment NA NA Human Human -DTXSID5027512 Css NA 0.1033 mg/L 3compartmentss NA 50% Human Human -DTXSID5027512 Css NA 1.003 mg/L 3compartmentss NA 95% Human Human -DTXSID5027512 Css NA 0.1055 mg/L PBTK NA 50% Human Human -DTXSID5027512 Css NA 0.7428 mg/L PBTK NA 95% Human Human -DTXSID5027512 Clint NA 4.897 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027512 Fup NA 0.6809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027512 Vd NA 2.203 L/kg 1compartment NA NA Rat Human +DTXSID5027489 TK.Half.Life NA 0.7386 hours 1compartment NA NA Rat Human +DTXSID5027489 Css NA 0.007274 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027489 Css NA 0.04285 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027489 Css NA 0.005784 mg/L PBTK NA 50% Rat Human +DTXSID5027489 Css NA 0.03056 mg/L PBTK NA 95% Rat Human +DTXSID5027512 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027512 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027512 Vd NA 1.418 L/kg 1compartment NA NA Human Human +DTXSID5027512 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5027512 TK.Half.Life NA 23.05 hours 1compartment NA NA Human Human +DTXSID5027512 Css NA 1.328 mg/L 3compartmentss NA 50% Human Human +DTXSID5027512 Css NA 6.269 mg/L 3compartmentss NA 95% Human Human +DTXSID5027512 Css NA 1.149 mg/L PBTK NA 50% Human Human +DTXSID5027512 Css NA 4.29 mg/L PBTK NA 95% Human Human +DTXSID5027512 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027512 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027512 Vd NA 1.425 L/kg 1compartment NA NA Rat Human DTXSID5027512 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027512 TK.Half.Life NA 1.738 hours 1compartment NA NA Rat Human -DTXSID5027512 Css NA 0.04656 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027512 Css NA 0.447 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027512 Css NA 0.0483 mg/L PBTK NA 50% Rat Human -DTXSID5027512 Css NA 0.2919 mg/L PBTK NA 95% Rat Human -DTXSID5027518 Clint NA 215.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027518 Fup NA 0.4787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027518 Vd NA 3.662 L/kg 1compartment NA NA Human Human -DTXSID5027518 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027518 TK.Half.Life NA 13.63 hours 1compartment NA NA Human Human -DTXSID5027518 Css NA 0.3318 mg/L 3compartmentss NA 50% Human Human -DTXSID5027518 Css NA 1.902 mg/L 3compartmentss NA 95% Human Human -DTXSID5027518 Css NA 0.2418 mg/L PBTK NA 50% Human Human -DTXSID5027518 Css NA 1.395 mg/L PBTK NA 95% Human Human -DTXSID5027518 Clint NA 215.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027518 Fup NA 0.4787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027518 Vd NA 2.761 L/kg 1compartment NA NA Rat Human -DTXSID5027518 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027518 TK.Half.Life NA 2.307 hours 1compartment NA NA Rat Human -DTXSID5027518 Css NA 0.1899 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027518 Css NA 0.8007 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027518 Css NA 0.1322 mg/L PBTK NA 50% Rat Human -DTXSID5027518 Css NA 0.5563 mg/L PBTK NA 95% Rat Human -DTXSID5027641 Clint NA 36.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027641 Fup NA 0.1968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027641 Vd NA 1.524 L/kg 1compartment NA NA Human Human +DTXSID5027512 TK.Half.Life NA 7.896 hours 1compartment NA NA Rat Human +DTXSID5027512 Css NA 0.02368 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027512 Css NA 0.1639 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027512 Css NA 0.02008 mg/L PBTK NA 50% Rat Human +DTXSID5027512 Css NA 0.1163 mg/L PBTK NA 95% Rat Human +DTXSID5027564 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027564 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027564 Vd NA 1.886 L/kg 1compartment NA NA Human Human +DTXSID5027564 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5027564 TK.Half.Life NA 2.358 hours 1compartment NA NA Human Human +DTXSID5027564 Css NA 0.06435 mg/L 3compartmentss NA 50% Human Human +DTXSID5027564 Css NA 0.4723 mg/L 3compartmentss NA 95% Human Human +DTXSID5027564 Css NA 0.05114 mg/L PBTK NA 50% Human Human +DTXSID5027564 Css NA 0.3476 mg/L PBTK NA 95% Human Human +DTXSID5027564 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027564 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027564 Vd NA 1.513 L/kg 1compartment NA NA Rat Human +DTXSID5027564 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5027564 TK.Half.Life NA 0.8632 hours 1compartment NA NA Rat Human +DTXSID5027564 Css NA 0.007934 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027564 Css NA 0.04507 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027564 Css NA 0.006341 mg/L PBTK NA 50% Rat Human +DTXSID5027564 Css NA 0.0328 mg/L PBTK NA 95% Rat Human +DTXSID5027641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027641 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027641 Vd NA 2.838 L/kg 1compartment NA NA Human Human DTXSID5027641 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027641 TK.Half.Life NA 2.123 hours 1compartment NA NA Human Human -DTXSID5027641 Css NA 0.07916 mg/L 3compartmentss NA 50% Human Human -DTXSID5027641 Css NA 0.535 mg/L 3compartmentss NA 95% Human Human -DTXSID5027641 Css NA 0.05658 mg/L PBTK NA 50% Human Human -DTXSID5027641 Css NA 0.363 mg/L PBTK NA 95% Human Human -DTXSID5027641 Clint NA 36.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027641 Fup NA 0.1968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027641 Vd NA 1.199 L/kg 1compartment NA NA Rat Human +DTXSID5027641 TK.Half.Life NA 9.619 hours 1compartment NA NA Human Human +DTXSID5027641 Css NA 0.3078 mg/L 3compartmentss NA 50% Human Human +DTXSID5027641 Css NA 1.95 mg/L 3compartmentss NA 95% Human Human +DTXSID5027641 Css NA 0.2238 mg/L PBTK NA 50% Human Human +DTXSID5027641 Css NA 1.351 mg/L PBTK NA 95% Human Human +DTXSID5027641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027641 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027641 Vd NA 2.152 L/kg 1compartment NA NA Rat Human DTXSID5027641 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027641 TK.Half.Life NA 0.8077 hours 1compartment NA NA Rat Human -DTXSID5027641 Css NA 0.04346 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027641 Css NA 0.2358 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027641 Css NA 0.02975 mg/L PBTK NA 50% Rat Human -DTXSID5027641 Css NA 0.1521 mg/L PBTK NA 95% Rat Human -DTXSID5027728 Clint NA 730.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027728 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027728 Vd NA 2354 L/kg 1compartment NA NA Human Human -DTXSID5027728 Days.Css NA 538 Days PBTK NA NA Human Human -DTXSID5027728 TK.Half.Life NA 2122 hours 1compartment NA NA Human Human -DTXSID5027728 Css NA 0.0001876 mg/L 3compartmentss NA 50% Human Human -DTXSID5027728 Css NA 0.001147 mg/L 3compartmentss NA 95% Human Human -DTXSID5027728 Css NA 0.07504 mg/L PBTK NA 50% Human Human -DTXSID5027728 Css NA 0.4389 mg/L PBTK NA 95% Human Human -DTXSID5027728 Clint NA 730.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027728 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027728 Vd NA 2183 L/kg 1compartment NA NA Rat Human -DTXSID5027728 Days.Css NA 371 Days PBTK NA NA Rat Human -DTXSID5027728 TK.Half.Life NA 369.9 hours 1compartment NA NA Rat Human -DTXSID5027728 Css NA 9.572e-05 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027728 Css NA 0.0004058 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027728 Css NA 0.04087 mg/L PBTK NA 50% Rat Human -DTXSID5027728 Css NA 0.1733 mg/L PBTK NA 95% Rat Human +DTXSID5027641 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human +DTXSID5027641 Css NA 0.03898 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027641 Css NA 0.1882 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027641 Css NA 0.02819 mg/L PBTK NA 50% Rat Human +DTXSID5027641 Css NA 0.1322 mg/L PBTK NA 95% Rat Human DTXSID5027770 Clint NA 5.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5027770 Fup NA 0.5491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027770 Vd NA 0.693 L/kg 1compartment NA NA Human Human +DTXSID5027770 Vd NA 0.3821 L/kg 1compartment NA NA Human Human DTXSID5027770 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027770 TK.Half.Life NA 1.113 hours 1compartment NA NA Human Human -DTXSID5027770 Css NA 0.1242 mg/L 3compartmentss NA 50% Human Human -DTXSID5027770 Css NA 1.066 mg/L 3compartmentss NA 95% Human Human -DTXSID5027770 Css NA 0.1028 mg/L PBTK NA 50% Human Human -DTXSID5027770 Css NA 0.7303 mg/L PBTK NA 95% Human Human +DTXSID5027770 TK.Half.Life NA 0.3044 hours 1compartment NA NA Human Human +DTXSID5027770 Css NA 0.004311 mg/L 3compartmentss NA 50% Human Human +DTXSID5027770 Css NA 0.07454 mg/L 3compartmentss NA 95% Human Human +DTXSID5027770 Css NA 0.003072 mg/L PBTK NA 50% Human Human +DTXSID5027770 Css NA 0.04734 mg/L PBTK NA 95% Human Human DTXSID5027770 Clint NA 5.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5027770 Fup NA 0.5491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027770 Vd NA 0.6937 L/kg 1compartment NA NA Rat Human +DTXSID5027770 Vd NA 0.4112 L/kg 1compartment NA NA Rat Human DTXSID5027770 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027770 TK.Half.Life NA 0.6123 hours 1compartment NA NA Rat Human -DTXSID5027770 Css NA 0.06006 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027770 Css NA 0.4483 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027770 Css NA 0.04828 mg/L PBTK NA 50% Rat Human -DTXSID5027770 Css NA 0.2791 mg/L PBTK NA 95% Rat Human +DTXSID5027770 TK.Half.Life NA 0.1468 hours 1compartment NA NA Rat Human +DTXSID5027770 Css NA 0.0001479 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027770 Css NA 0.002996 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027770 Css NA 0.0001028 mg/L PBTK NA 50% Rat Human +DTXSID5027770 Css NA 0.001855 mg/L PBTK NA 95% Rat Human DTXSID5027772 Clint NA 8.113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5027772 Fup NA 0.8233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027772 Vd NA 1.76 L/kg 1compartment NA NA Human Human +DTXSID5027772 Vd NA 1.588 L/kg 1compartment NA NA Human Human DTXSID5027772 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027772 TK.Half.Life NA 1.695 hours 1compartment NA NA Human Human -DTXSID5027772 Css NA 0.06076 mg/L 3compartmentss NA 50% Human Human -DTXSID5027772 Css NA 0.5559 mg/L 3compartmentss NA 95% Human Human -DTXSID5027772 Css NA 0.05932 mg/L PBTK NA 50% Human Human -DTXSID5027772 Css NA 0.4304 mg/L PBTK NA 95% Human Human +DTXSID5027772 TK.Half.Life NA 1.554 hours 1compartment NA NA Human Human +DTXSID5027772 Css NA 0.05012 mg/L 3compartmentss NA 50% Human Human +DTXSID5027772 Css NA 0.5071 mg/L 3compartmentss NA 95% Human Human +DTXSID5027772 Css NA 0.04732 mg/L PBTK NA 50% Human Human +DTXSID5027772 Css NA 0.3843 mg/L PBTK NA 95% Human Human DTXSID5027772 Clint NA 8.113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5027772 Fup NA 0.8233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027772 Vd NA 1.757 L/kg 1compartment NA NA Rat Human +DTXSID5027772 Vd NA 1.588 L/kg 1compartment NA NA Rat Human DTXSID5027772 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027772 TK.Half.Life NA 0.9021 hours 1compartment NA NA Rat Human -DTXSID5027772 Css NA 0.02898 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027772 Css NA 0.2439 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027772 Css NA 0.0285 mg/L PBTK NA 50% Rat Human -DTXSID5027772 Css NA 0.1692 mg/L PBTK NA 95% Rat Human +DTXSID5027772 TK.Half.Life NA 0.8251 hours 1compartment NA NA Rat Human +DTXSID5027772 Css NA 0.001697 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027772 Css NA 0.01927 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027772 Css NA 0.001596 mg/L PBTK NA 50% Rat Human +DTXSID5027772 Css NA 0.01398 mg/L PBTK NA 95% Rat Human DTXSID5027774 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5027774 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027774 Vd NA 0.9122 L/kg 1compartment NA NA Human Human +DTXSID5027774 Vd NA 0.6794 L/kg 1compartment NA NA Human Human DTXSID5027774 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027774 TK.Half.Life NA 5.904 hours 1compartment NA NA Human Human -DTXSID5027774 Css NA 0.8136 mg/L 3compartmentss NA 50% Human Human -DTXSID5027774 Css NA 5.506 mg/L 3compartmentss NA 95% Human Human -DTXSID5027774 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID5027774 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID5027774 TK.Half.Life NA 4.398 hours 1compartment NA NA Human Human +DTXSID5027774 Css NA 0.7171 mg/L 3compartmentss NA 50% Human Human +DTXSID5027774 Css NA 5.074 mg/L 3compartmentss NA 95% Human Human +DTXSID5027774 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID5027774 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID5027774 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5027774 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027774 Vd NA 0.9526 L/kg 1compartment NA NA Rat Human +DTXSID5027774 Vd NA 0.7336 L/kg 1compartment NA NA Rat Human DTXSID5027774 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027774 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human -DTXSID5027774 Css NA 0.2038 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027774 Css NA 1.321 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027774 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID5027774 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5027803 Clint NA 33.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027803 Fup NA 0.6228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027803 Vd NA 3.275 L/kg 1compartment NA NA Human Human +DTXSID5027774 TK.Half.Life NA 1.617 hours 1compartment NA NA Rat Human +DTXSID5027774 Css NA 0.01316 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027774 Css NA 0.1004 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027774 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID5027774 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID5027803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027803 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027803 Vd NA 2.95 L/kg 1compartment NA NA Human Human DTXSID5027803 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027803 TK.Half.Life NA 1.892 hours 1compartment NA NA Human Human -DTXSID5027803 Css NA 0.01552 mg/L 3compartmentss NA 50% Human Human -DTXSID5027803 Css NA 0.1871 mg/L 3compartmentss NA 95% Human Human -DTXSID5027803 Css NA 0.01851 mg/L PBTK NA 50% Human Human -DTXSID5027803 Css NA 0.1595 mg/L PBTK NA 95% Human Human -DTXSID5027803 Clint NA 33.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027803 Fup NA 0.6228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027803 Vd NA 3.328 L/kg 1compartment NA NA Rat Human +DTXSID5027803 TK.Half.Life NA 2.143 hours 1compartment NA NA Human Human +DTXSID5027803 Css NA 0.02446 mg/L 3compartmentss NA 50% Human Human +DTXSID5027803 Css NA 0.3115 mg/L 3compartmentss NA 95% Human Human +DTXSID5027803 Css NA 0.02764 mg/L PBTK NA 50% Human Human +DTXSID5027803 Css NA 0.2496 mg/L PBTK NA 95% Human Human +DTXSID5027803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027803 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027803 Vd NA 2.992 L/kg 1compartment NA NA Rat Human DTXSID5027803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027803 TK.Half.Life NA 0.9661 hours 1compartment NA NA Rat Human -DTXSID5027803 Css NA 0.007727 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027803 Css NA 0.08556 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027803 Css NA 0.009278 mg/L PBTK NA 50% Rat Human -DTXSID5027803 Css NA 0.06893 mg/L PBTK NA 95% Rat Human -DTXSID5027805 Clint NA 9.638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027805 Fup NA 0.5587 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027805 Vd NA 1.053 L/kg 1compartment NA NA Human Human +DTXSID5027803 TK.Half.Life NA 1.14 hours 1compartment NA NA Rat Human +DTXSID5027803 Css NA 0.002872 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027803 Css NA 0.0327 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027803 Css NA 0.003395 mg/L PBTK NA 50% Rat Human +DTXSID5027803 Css NA 0.0257 mg/L PBTK NA 95% Rat Human +DTXSID5027805 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027805 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5027805 Vd NA 0.4337 L/kg 1compartment NA NA Human Human DTXSID5027805 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027805 TK.Half.Life NA 1.336 hours 1compartment NA NA Human Human -DTXSID5027805 Css NA 0.07997 mg/L 3compartmentss NA 50% Human Human -DTXSID5027805 Css NA 0.7726 mg/L 3compartmentss NA 95% Human Human -DTXSID5027805 Css NA 0.06609 mg/L PBTK NA 50% Human Human -DTXSID5027805 Css NA 0.5333 mg/L PBTK NA 95% Human Human -DTXSID5027805 Clint NA 9.638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027805 Fup NA 0.5587 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027805 Vd NA 0.9647 L/kg 1compartment NA NA Rat Human +DTXSID5027805 TK.Half.Life NA 0.6985 hours 1compartment NA NA Human Human +DTXSID5027805 Css NA 0.1015 mg/L 3compartmentss NA 50% Human Human +DTXSID5027805 Css NA 0.7296 mg/L 3compartmentss NA 95% Human Human +DTXSID5027805 Css NA 0.06784 mg/L PBTK NA 50% Human Human +DTXSID5027805 Css NA 0.4631 mg/L PBTK NA 95% Human Human +DTXSID5027805 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027805 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5027805 Vd NA 0.4264 L/kg 1compartment NA NA Rat Human DTXSID5027805 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027805 TK.Half.Life NA 0.6412 hours 1compartment NA NA Rat Human -DTXSID5027805 Css NA 0.04123 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027805 Css NA 0.3369 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027805 Css NA 0.03306 mg/L PBTK NA 50% Rat Human -DTXSID5027805 Css NA 0.2081 mg/L PBTK NA 95% Rat Human -DTXSID5027851 Clint NA 0.2566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027851 Fup NA 0.2419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027851 Vd NA 3.105 L/kg 1compartment NA NA Human Human -DTXSID5027851 Days.Css NA 380 Days PBTK NA NA Human Human -DTXSID5027851 TK.Half.Life NA 1464 hours 1compartment NA NA Human Human -DTXSID5027851 Css NA 53.74 mg/L 3compartmentss NA 50% Human Human -DTXSID5027851 Css NA 166.6 mg/L 3compartmentss NA 95% Human Human -DTXSID5027851 Css NA 38.1 mg/L PBTK NA 50% Human Human -DTXSID5027851 Css NA 110.4 mg/L PBTK NA 95% Human Human -DTXSID5027851 Clint NA 0.2566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027851 Fup NA 0.2419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027851 Vd NA 2.333 L/kg 1compartment NA NA Rat Human -DTXSID5027851 Days.Css NA 135 Days PBTK NA NA Rat Human -DTXSID5027851 TK.Half.Life NA 135.3 hours 1compartment NA NA Rat Human -DTXSID5027851 Css NA 20.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027851 Css NA 46.97 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027851 Css NA 13.98 mg/L PBTK NA 50% Rat Human -DTXSID5027851 Css NA 28.8 mg/L PBTK NA 95% Rat Human -DTXSID5027857 Clint NA 170.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027857 Fup NA 0.1941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027857 Vd NA 2.086 L/kg 1compartment NA NA Human Human -DTXSID5027857 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027857 TK.Half.Life NA 1.984 hours 1compartment NA NA Human Human -DTXSID5027857 Css NA 0.02245 mg/L 3compartmentss NA 50% Human Human -DTXSID5027857 Css NA 0.1557 mg/L 3compartmentss NA 95% Human Human -DTXSID5027857 Css NA 0.01623 mg/L PBTK NA 50% Human Human -DTXSID5027857 Css NA 0.1061 mg/L PBTK NA 95% Human Human -DTXSID5027857 Clint NA 170.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027857 Fup NA 0.1941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027857 Vd NA 1.604 L/kg 1compartment NA NA Rat Human -DTXSID5027857 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027857 TK.Half.Life NA 0.6627 hours 1compartment NA NA Rat Human -DTXSID5027857 Css NA 0.01261 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027857 Css NA 0.07064 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027857 Css NA 0.008751 mg/L PBTK NA 50% Rat Human -DTXSID5027857 Css NA 0.04786 mg/L PBTK NA 95% Rat Human -DTXSID5027932 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027932 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027932 Vd NA 0.5326 L/kg 1compartment NA NA Human Human -DTXSID5027932 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027932 TK.Half.Life NA 9.524 hours 1compartment NA NA Human Human -DTXSID5027932 Css NA 3.125 mg/L 3compartmentss NA 50% Human Human -DTXSID5027932 Css NA 32.01 mg/L 3compartmentss NA 95% Human Human -DTXSID5027932 Css NA 1.898 mg/L PBTK NA 50% Human Human -DTXSID5027932 Css NA 18.94 mg/L PBTK NA 95% Human Human -DTXSID5027932 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027932 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027932 Vd NA 0.4356 L/kg 1compartment NA NA Rat Human -DTXSID5027932 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027932 TK.Half.Life NA 5.154 hours 1compartment NA NA Rat Human -DTXSID5027932 Css NA 1.819 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027932 Css NA 15.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027932 Css NA 1.034 mg/L PBTK NA 50% Rat Human -DTXSID5027932 Css NA 8.561 mg/L PBTK NA 95% Rat Human -DTXSID5027936 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027936 Fup NA 0.815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027936 Vd NA 1.023 L/kg 1compartment NA NA Human Human -DTXSID5027936 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5027936 TK.Half.Life NA 8.327 hours 1compartment NA NA Human Human -DTXSID5027936 Css NA 0.927 mg/L 3compartmentss NA 50% Human Human -DTXSID5027936 Css NA 5.825 mg/L 3compartmentss NA 95% Human Human -DTXSID5027936 Css NA 0.8149 mg/L PBTK NA 50% Human Human -DTXSID5027936 Css NA 3.882 mg/L PBTK NA 95% Human Human -DTXSID5027936 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027936 Fup NA 0.815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027936 Vd NA 0.994 L/kg 1compartment NA NA Rat Human -DTXSID5027936 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5027936 TK.Half.Life NA 2.705 hours 1compartment NA NA Rat Human -DTXSID5027936 Css NA 0.239 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027936 Css NA 1.481 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027936 Css NA 0.2036 mg/L PBTK NA 50% Rat Human -DTXSID5027936 Css NA 0.9041 mg/L PBTK NA 95% Rat Human -DTXSID5027982 Clint NA 218.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027982 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5027982 Vd NA 215.7 L/kg 1compartment NA NA Human Human -DTXSID5027982 Days.Css NA 144 Days PBTK NA NA Human Human -DTXSID5027982 TK.Half.Life NA 640.6 hours 1compartment NA NA Human Human -DTXSID5027982 Css NA 0.00844 mg/L 3compartmentss NA 50% Human Human -DTXSID5027982 Css NA 0.05255 mg/L 3compartmentss NA 95% Human Human -DTXSID5027982 Css NA 0.2458 mg/L PBTK NA 50% Human Human -DTXSID5027982 Css NA 1.398 mg/L PBTK NA 95% Human Human -DTXSID5027982 Clint NA 218.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027982 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5027982 Vd NA 190.9 L/kg 1compartment NA NA Rat Human -DTXSID5027982 Days.Css NA 99 Days PBTK NA NA Rat Human -DTXSID5027982 TK.Half.Life NA 101.1 hours 1compartment NA NA Rat Human -DTXSID5027982 Css NA 0.004296 mg/L 3compartmentss NA 50% Rat Human -DTXSID5027982 Css NA 0.01875 mg/L 3compartmentss NA 95% Rat Human -DTXSID5027982 Css NA 0.1328 mg/L PBTK NA 50% Rat Human -DTXSID5027982 Css NA 0.573 mg/L PBTK NA 95% Rat Human -DTXSID5028033 Clint NA 1125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5028033 Fup NA 0.003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5028033 Vd NA 41890 L/kg 1compartment NA NA Human Human -DTXSID5028033 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID5028033 TK.Half.Life NA 24650 hours 1compartment NA NA Human Human -DTXSID5028033 Css NA 6.074e-06 mg/L 3compartmentss NA 50% Human Human -DTXSID5028033 Css NA 3.745e-05 mg/L 3compartmentss NA 95% Human Human -DTXSID5028033 Css NA 0.04937 mg/L PBTK NA 50% Human Human -DTXSID5028033 Css NA 0.2772 mg/L PBTK NA 95% Human Human -DTXSID5028033 Clint NA 1125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5028033 Fup NA 0.003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5028033 Vd NA 39720 L/kg 1compartment NA NA Rat Human -DTXSID5028033 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID5028033 TK.Half.Life NA 4458 hours 1compartment NA NA Rat Human -DTXSID5028033 Css NA 3.079e-06 mg/L 3compartmentss NA 50% Rat Human -DTXSID5028033 Css NA 1.335e-05 mg/L 3compartmentss NA 95% Rat Human -DTXSID5028033 Css NA 0.02666 mg/L PBTK NA 50% Rat Human -DTXSID5028033 Css NA 0.1162 mg/L PBTK NA 95% Rat Human -DTXSID5028665 Clint NA 137.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5028665 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5028665 Vd NA 510.6 L/kg 1compartment NA NA Human Human -DTXSID5028665 Days.Css NA 623 Days PBTK NA NA Human Human -DTXSID5028665 TK.Half.Life NA 2416 hours 1compartment NA NA Human Human -DTXSID5028665 Css NA 0.00524 mg/L 3compartmentss NA 50% Human Human -DTXSID5028665 Css NA 0.03227 mg/L 3compartmentss NA 95% Human Human -DTXSID5028665 Css NA 0.3962 mg/L PBTK NA 50% Human Human -DTXSID5028665 Css NA 2.174 mg/L PBTK NA 95% Human Human -DTXSID5028665 Clint NA 137.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5028665 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5028665 Vd NA 461.5 L/kg 1compartment NA NA Rat Human -DTXSID5028665 Days.Css NA 413 Days PBTK NA NA Rat Human -DTXSID5028665 TK.Half.Life NA 398.6 hours 1compartment NA NA Rat Human -DTXSID5028665 Css NA 0.002656 mg/L 3compartmentss NA 50% Rat Human -DTXSID5028665 Css NA 0.01121 mg/L 3compartmentss NA 95% Rat Human -DTXSID5028665 Css NA 0.2147 mg/L PBTK NA 50% Rat Human -DTXSID5028665 Css NA 0.9037 mg/L PBTK NA 95% Rat Human -DTXSID5029055 Clint NA 131.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5027805 TK.Half.Life NA 0.3771 hours 1compartment NA NA Rat Human +DTXSID5027805 Css NA 0.01308 mg/L 3compartmentss NA 50% Rat Human +DTXSID5027805 Css NA 0.07057 mg/L 3compartmentss NA 95% Rat Human +DTXSID5027805 Css NA 0.008526 mg/L PBTK NA 50% Rat Human +DTXSID5027805 Css NA 0.04418 mg/L PBTK NA 95% Rat Human +DTXSID50279249 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50279249 Fup 0.0339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50279249 Vd NA 0.9747 L/kg 1compartment NA NA Human Human +DTXSID50279249 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50279249 TK.Half.Life NA 5.7 hours 1compartment NA NA Human Human +DTXSID50279249 Css NA 0.9004 mg/L 3compartmentss NA 50% Human Human +DTXSID50279249 Css NA 7.456 mg/L 3compartmentss NA 95% Human Human +DTXSID50279249 Css NA 0.552 mg/L PBTK NA 50% Human Human +DTXSID50279249 Css NA 4.431 mg/L PBTK NA 95% Human Human +DTXSID50279249 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50279249 Fup 0.0339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50279249 Vd NA 0.7362 L/kg 1compartment NA NA Rat Human +DTXSID50279249 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50279249 TK.Half.Life NA 2.515 hours 1compartment NA NA Rat Human +DTXSID50279249 Css NA 0.118 mg/L 3compartmentss NA 50% Rat Human +DTXSID50279249 Css NA 0.7556 mg/L 3compartmentss NA 95% Rat Human +DTXSID50279249 Css NA 0.0703 mg/L PBTK NA 50% Rat Human +DTXSID50279249 Css NA 0.4373 mg/L PBTK NA 95% Rat Human +DTXSID5028114 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5028114 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5028114 Vd NA 1.47 L/kg 1compartment NA NA Human Human +DTXSID5028114 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5028114 TK.Half.Life NA 1.731 hours 1compartment NA NA Human Human +DTXSID5028114 Css NA 0.05634 mg/L 3compartmentss NA 50% Human Human +DTXSID5028114 Css NA 0.4339 mg/L 3compartmentss NA 95% Human Human +DTXSID5028114 Css NA 0.04453 mg/L PBTK NA 50% Human Human +DTXSID5028114 Css NA 0.3121 mg/L PBTK NA 95% Human Human +DTXSID5028114 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5028114 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5028114 Vd NA 1.216 L/kg 1compartment NA NA Rat Human +DTXSID5028114 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5028114 TK.Half.Life NA 0.6978 hours 1compartment NA NA Rat Human +DTXSID5028114 Css NA 0.006876 mg/L 3compartmentss NA 50% Rat Human +DTXSID5028114 Css NA 0.04195 mg/L 3compartmentss NA 95% Rat Human +DTXSID5028114 Css NA 0.005457 mg/L PBTK NA 50% Rat Human +DTXSID5028114 Css NA 0.02929 mg/L PBTK NA 95% Rat Human +DTXSID5029055 Clint 104 NA uL/min/million hepatocytes NA Black 2021 NA Human Human DTXSID5029055 Fup 1.41e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5029055 Vd NA 0.6706 L/kg 1compartment NA NA Human Human -DTXSID5029055 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5029055 TK.Half.Life NA 27.42 hours 1compartment NA NA Human Human -DTXSID5029055 Css NA 0.4916 mg/L 3compartmentss NA 50% Human Human -DTXSID5029055 Css NA 3.403 mg/L 3compartmentss NA 95% Human Human -DTXSID5029055 Css NA 0.3349 mg/L PBTK NA 50% Human Human -DTXSID5029055 Css NA 2.226 mg/L PBTK NA 95% Human Human -DTXSID5029055 Clint NA 131.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5029055 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5029055 TK.Half.Life NA 34.48 hours 1compartment NA NA Human Human +DTXSID5029055 Css NA 0.5157 mg/L 3compartmentss NA 50% Human Human +DTXSID5029055 Css NA 3.738 mg/L 3compartmentss NA 95% Human Human +DTXSID5029055 Css NA 0.3514 mg/L PBTK NA 50% Human Human +DTXSID5029055 Css NA 2.461 mg/L PBTK NA 95% Human Human +DTXSID5029055 Clint 104 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human DTXSID5029055 Fup 1.41e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5029055 Vd NA 0.49 L/kg 1compartment NA NA Rat Human -DTXSID5029055 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5029055 TK.Half.Life NA 13.94 hours 1compartment NA NA Rat Human -DTXSID5029055 Css NA 0.2715 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029055 Css NA 1.803 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029055 Css NA 0.1758 mg/L PBTK NA 50% Rat Human -DTXSID5029055 Css NA 1.111 mg/L PBTK NA 95% Rat Human -DTXSID5029059 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029059 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029059 Vd NA 3.983 L/kg 1compartment NA NA Human Human -DTXSID5029059 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID5029059 TK.Half.Life NA 190500 hours 1compartment NA NA Human Human -DTXSID5029059 Css NA 4962 mg/L 3compartmentss NA 50% Human Human -DTXSID5029059 Css NA 11220 mg/L 3compartmentss NA 95% Human Human -DTXSID5029059 Css NA 3699 mg/L PBTK NA 50% Human Human -DTXSID5029059 Css NA 7983 mg/L PBTK NA 95% Human Human -DTXSID5029059 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029059 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029059 Vd NA 3.012 L/kg 1compartment NA NA Rat Human -DTXSID5029059 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID5029059 TK.Half.Life NA 12200 hours 1compartment NA NA Rat Human -DTXSID5029059 Css NA 1381 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029059 Css NA 1966 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029059 Css NA 992.8 mg/L PBTK NA 50% Rat Human -DTXSID5029059 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID5029136 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029136 Fup NA 0.0635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029136 Vd NA 0.3181 L/kg 1compartment NA NA Human Human -DTXSID5029136 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5029136 TK.Half.Life NA 17.42 hours 1compartment NA NA Human Human -DTXSID5029136 Css NA 8.723 mg/L 3compartmentss NA 50% Human Human -DTXSID5029136 Css NA 43.69 mg/L 3compartmentss NA 95% Human Human -DTXSID5029136 Css NA 5.43 mg/L PBTK NA 50% Human Human -DTXSID5029136 Css NA 25.81 mg/L PBTK NA 95% Human Human -DTXSID5029136 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029136 Fup NA 0.0635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029136 Vd NA 0.3088 L/kg 1compartment NA NA Rat Human +DTXSID5029055 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5029055 TK.Half.Life NA 17.55 hours 1compartment NA NA Rat Human +DTXSID5029055 Css NA 0.01945 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029055 Css NA 0.1658 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029055 Css NA 0.01281 mg/L PBTK NA 50% Rat Human +DTXSID5029055 Css NA 0.1037 mg/L PBTK NA 95% Rat Human +DTXSID5029136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029136 Fup 0.0904 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029136 Vd NA 0.4533 L/kg 1compartment NA NA Human Human +DTXSID5029136 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5029136 TK.Half.Life NA 1.242 hours 1compartment NA NA Human Human +DTXSID5029136 Css NA 0.306 mg/L 3compartmentss NA 50% Human Human +DTXSID5029136 Css NA 2.47 mg/L 3compartmentss NA 95% Human Human +DTXSID5029136 Css NA 0.1992 mg/L PBTK NA 50% Human Human +DTXSID5029136 Css NA 1.521 mg/L PBTK NA 95% Human Human +DTXSID5029136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029136 Fup 0.0904 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029136 Vd NA 0.4452 L/kg 1compartment NA NA Rat Human DTXSID5029136 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5029136 TK.Half.Life NA 7.553 hours 1compartment NA NA Rat Human -DTXSID5029136 Css NA 3.302 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029136 Css NA 13.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029136 Css NA 1.922 mg/L PBTK NA 50% Rat Human -DTXSID5029136 Css NA 7.462 mg/L PBTK NA 95% Rat Human +DTXSID5029136 TK.Half.Life NA 0.7365 hours 1compartment NA NA Rat Human +DTXSID5029136 Css NA 0.03997 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029136 Css NA 0.2556 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029136 Css NA 0.02539 mg/L PBTK NA 50% Rat Human +DTXSID5029136 Css NA 0.1511 mg/L PBTK NA 95% Rat Human DTXSID5029182 Clint NA 0.02237 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5029182 Fup NA 0.4183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5029182 Vd NA 0.4509 L/kg 1compartment NA NA Human Human DTXSID5029182 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5029182 TK.Half.Life NA 6.723 hours 1compartment NA NA Human Human -DTXSID5029182 Css NA 1.683 mg/L 3compartmentss NA 50% Human Human -DTXSID5029182 Css NA 7.742 mg/L 3compartmentss NA 95% Human Human -DTXSID5029182 Css NA 1.229 mg/L PBTK NA 50% Human Human -DTXSID5029182 Css NA 4.753 mg/L PBTK NA 95% Human Human +DTXSID5029182 Css NA 1.444 mg/L 3compartmentss NA 50% Human Human +DTXSID5029182 Css NA 6.586 mg/L 3compartmentss NA 95% Human Human +DTXSID5029182 Css NA 1.052 mg/L PBTK NA 50% Human Human +DTXSID5029182 Css NA 4.137 mg/L PBTK NA 95% Human Human DTXSID5029182 Clint NA 0.02237 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5029182 Fup NA 0.4183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5029182 Vd NA 0.4546 L/kg 1compartment NA NA Rat Human DTXSID5029182 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5029182 TK.Half.Life NA 2.354 hours 1compartment NA NA Rat Human -DTXSID5029182 Css NA 0.478 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029182 Css NA 1.826 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029182 Css NA 0.3301 mg/L PBTK NA 50% Rat Human -DTXSID5029182 Css NA 1.071 mg/L PBTK NA 95% Rat Human +DTXSID5029182 Css NA 0.02664 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029182 Css NA 0.1807 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029182 Css NA 0.01863 mg/L PBTK NA 50% Rat Human +DTXSID5029182 Css NA 0.1124 mg/L PBTK NA 95% Rat Human DTXSID5029184 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5029184 Fup NA 0.5319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029184 Vd NA 0.4797 L/kg 1compartment NA NA Human Human +DTXSID5029184 Vd NA 0.4837 L/kg 1compartment NA NA Human Human DTXSID5029184 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5029184 TK.Half.Life NA 5.835 hours 1compartment NA NA Human Human -DTXSID5029184 Css NA 1.441 mg/L 3compartmentss NA 50% Human Human -DTXSID5029184 Css NA 8.516 mg/L 3compartmentss NA 95% Human Human -DTXSID5029184 Css NA 1.069 mg/L PBTK NA 50% Human Human -DTXSID5029184 Css NA 5.271 mg/L PBTK NA 95% Human Human +DTXSID5029184 TK.Half.Life NA 5.884 hours 1compartment NA NA Human Human +DTXSID5029184 Css NA 1.405 mg/L 3compartmentss NA 50% Human Human +DTXSID5029184 Css NA 8.104 mg/L 3compartmentss NA 95% Human Human +DTXSID5029184 Css NA 1.046 mg/L PBTK NA 50% Human Human +DTXSID5029184 Css NA 4.982 mg/L PBTK NA 95% Human Human DTXSID5029184 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5029184 Fup NA 0.5319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029184 Vd NA 0.5121 L/kg 1compartment NA NA Rat Human +DTXSID5029184 Vd NA 0.5168 L/kg 1compartment NA NA Rat Human DTXSID5029184 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5029184 TK.Half.Life NA 2.123 hours 1compartment NA NA Rat Human -DTXSID5029184 Css NA 0.3826 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029184 Css NA 1.962 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029184 Css NA 0.2713 mg/L PBTK NA 50% Rat Human -DTXSID5029184 Css NA 1.139 mg/L PBTK NA 95% Rat Human +DTXSID5029184 TK.Half.Life NA 2.143 hours 1compartment NA NA Rat Human +DTXSID5029184 Css NA 0.0865 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029184 Css NA 0.4489 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029184 Css NA 0.06351 mg/L PBTK NA 50% Rat Human +DTXSID5029184 Css NA 0.2697 mg/L PBTK NA 95% Rat Human DTXSID5029186 Clint NA 0.148 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5029186 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029186 Vd NA 0.8951 L/kg 1compartment NA NA Human Human +DTXSID5029186 Vd NA 1.283 L/kg 1compartment NA NA Human Human DTXSID5029186 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5029186 TK.Half.Life NA 4.69 hours 1compartment NA NA Human Human -DTXSID5029186 Css NA 0.629 mg/L 3compartmentss NA 50% Human Human -DTXSID5029186 Css NA 4.225 mg/L 3compartmentss NA 95% Human Human -DTXSID5029186 Css NA 0.5473 mg/L PBTK NA 50% Human Human -DTXSID5029186 Css NA 2.697 mg/L PBTK NA 95% Human Human +DTXSID5029186 TK.Half.Life NA 7.019 hours 1compartment NA NA Human Human +DTXSID5029186 Css NA 0.5024 mg/L 3compartmentss NA 50% Human Human +DTXSID5029186 Css NA 3.303 mg/L 3compartmentss NA 95% Human Human +DTXSID5029186 Css NA 0.4704 mg/L PBTK NA 50% Human Human +DTXSID5029186 Css NA 2.283 mg/L PBTK NA 95% Human Human DTXSID5029186 Clint NA 0.148 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5029186 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029186 Vd NA 0.9164 L/kg 1compartment NA NA Rat Human +DTXSID5029186 Vd NA 1.223 L/kg 1compartment NA NA Rat Human DTXSID5029186 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5029186 TK.Half.Life NA 1.81 hours 1compartment NA NA Rat Human -DTXSID5029186 Css NA 0.1804 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029186 Css NA 1.153 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029186 Css NA 0.154 mg/L PBTK NA 50% Rat Human -DTXSID5029186 Css NA 0.7024 mg/L PBTK NA 95% Rat Human -DTXSID5029211 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029211 Fup NA 0.0239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029211 Vd NA 0.22 L/kg 1compartment NA NA Human Human -DTXSID5029211 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID5029211 TK.Half.Life NA 59.55 hours 1compartment NA NA Human Human -DTXSID5029211 Css NA 46.37 mg/L 3compartmentss NA 50% Human Human -DTXSID5029211 Css NA 279.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5029211 Css NA 27.46 mg/L PBTK NA 50% Human Human -DTXSID5029211 Css NA 162.9 mg/L PBTK NA 95% Human Human -DTXSID5029211 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029211 Fup NA 0.0239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029211 Vd NA 0.2162 L/kg 1compartment NA NA Rat Human -DTXSID5029211 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5029211 TK.Half.Life NA 19.95 hours 1compartment NA NA Rat Human -DTXSID5029211 Css NA 13.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029211 Css NA 68.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029211 Css NA 7.351 mg/L PBTK NA 50% Rat Human -DTXSID5029211 Css NA 36.96 mg/L PBTK NA 95% Rat Human -DTXSID5029217 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029217 Fup NA 0.8147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029217 Vd NA 1.004 L/kg 1compartment NA NA Human Human +DTXSID5029186 TK.Half.Life NA 2.44 hours 1compartment NA NA Rat Human +DTXSID5029186 Css NA 0.01 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029186 Css NA 0.09307 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029186 Css NA 0.009214 mg/L PBTK NA 50% Rat Human +DTXSID5029186 Css NA 0.06166 mg/L PBTK NA 95% Rat Human +DTXSID5029211 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029211 Fup 0.0737 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029211 Vd NA 0.319 L/kg 1compartment NA NA Human Human +DTXSID5029211 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5029211 TK.Half.Life NA 2.707 hours 1compartment NA NA Human Human +DTXSID5029211 Css NA 1.291 mg/L 3compartmentss NA 50% Human Human +DTXSID5029211 Css NA 8.816 mg/L 3compartmentss NA 95% Human Human +DTXSID5029211 Css NA 0.8076 mg/L PBTK NA 50% Human Human +DTXSID5029211 Css NA 5.165 mg/L PBTK NA 95% Human Human +DTXSID5029211 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029211 Fup 0.0737 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029211 Vd NA 0.3146 L/kg 1compartment NA NA Rat Human +DTXSID5029211 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5029211 TK.Half.Life NA 1.648 hours 1compartment NA NA Rat Human +DTXSID5029211 Css NA 0.1588 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029211 Css NA 0.8231 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029211 Css NA 0.09554 mg/L PBTK NA 50% Rat Human +DTXSID5029211 Css NA 0.4727 mg/L PBTK NA 95% Rat Human +DTXSID5029217 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029217 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029217 Vd NA 1.013 L/kg 1compartment NA NA Human Human DTXSID5029217 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5029217 TK.Half.Life NA 8.155 hours 1compartment NA NA Human Human -DTXSID5029217 Css NA 0.9344 mg/L 3compartmentss NA 50% Human Human -DTXSID5029217 Css NA 5.6 mg/L 3compartmentss NA 95% Human Human -DTXSID5029217 Css NA 0.8191 mg/L PBTK NA 50% Human Human -DTXSID5029217 Css NA 3.685 mg/L PBTK NA 95% Human Human -DTXSID5029217 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029217 Fup NA 0.8147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029217 Vd NA 0.9785 L/kg 1compartment NA NA Rat Human +DTXSID5029217 TK.Half.Life NA 9.409 hours 1compartment NA NA Human Human +DTXSID5029217 Css NA 0.865 mg/L 3compartmentss NA 50% Human Human +DTXSID5029217 Css NA 5.857 mg/L 3compartmentss NA 95% Human Human +DTXSID5029217 Css NA 0.7507 mg/L PBTK NA 50% Human Human +DTXSID5029217 Css NA 3.805 mg/L PBTK NA 95% Human Human +DTXSID5029217 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029217 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029217 Vd NA 0.9681 L/kg 1compartment NA NA Rat Human DTXSID5029217 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5029217 TK.Half.Life NA 2.663 hours 1compartment NA NA Rat Human -DTXSID5029217 Css NA 0.2389 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029217 Css NA 1.468 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029217 Css NA 0.203 mg/L PBTK NA 50% Rat Human -DTXSID5029217 Css NA 0.8955 mg/L PBTK NA 95% Rat Human -DTXSID5029263 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029263 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029263 Vd NA 0.7644 L/kg 1compartment NA NA Human Human +DTXSID5029217 TK.Half.Life NA 2.992 hours 1compartment NA NA Rat Human +DTXSID5029217 Css NA 0.01656 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029217 Css NA 0.1414 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029217 Css NA 0.01383 mg/L PBTK NA 50% Rat Human +DTXSID5029217 Css NA 0.09057 mg/L PBTK NA 95% Rat Human +DTXSID5029263 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029263 Fup 0.763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029263 Vd NA 0.6408 L/kg 1compartment NA NA Human Human DTXSID5029263 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5029263 TK.Half.Life NA 4.948 hours 1compartment NA NA Human Human -DTXSID5029263 Css NA 0.8339 mg/L 3compartmentss NA 50% Human Human -DTXSID5029263 Css NA 5.576 mg/L 3compartmentss NA 95% Human Human -DTXSID5029263 Css NA 0.6988 mg/L PBTK NA 50% Human Human -DTXSID5029263 Css NA 3.648 mg/L PBTK NA 95% Human Human -DTXSID5029263 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029263 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029263 Vd NA 0.8017 L/kg 1compartment NA NA Rat Human +DTXSID5029263 TK.Half.Life NA 5.432 hours 1compartment NA NA Human Human +DTXSID5029263 Css NA 0.8902 mg/L 3compartmentss NA 50% Human Human +DTXSID5029263 Css NA 5.704 mg/L 3compartmentss NA 95% Human Human +DTXSID5029263 Css NA 0.7129 mg/L PBTK NA 50% Human Human +DTXSID5029263 Css NA 3.613 mg/L PBTK NA 95% Human Human +DTXSID5029263 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029263 Fup 0.763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029263 Vd NA 0.6744 L/kg 1compartment NA NA Rat Human DTXSID5029263 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5029263 TK.Half.Life NA 1.768 hours 1compartment NA NA Rat Human -DTXSID5029263 Css NA 0.2094 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029263 Css NA 1.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029263 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID5029263 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5029265 Clint NA 21.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029265 Fup NA 0.2526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029265 Vd NA 1.119 L/kg 1compartment NA NA Human Human +DTXSID5029263 TK.Half.Life NA 1.949 hours 1compartment NA NA Rat Human +DTXSID5029263 Css NA 0.01704 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029263 Css NA 0.1291 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029263 Css NA 0.01312 mg/L PBTK NA 50% Rat Human +DTXSID5029263 Css NA 0.08273 mg/L PBTK NA 95% Rat Human +DTXSID5029265 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029265 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029265 Vd NA 0.9144 L/kg 1compartment NA NA Human Human DTXSID5029265 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5029265 TK.Half.Life NA 1.634 hours 1compartment NA NA Human Human -DTXSID5029265 Css NA 0.08857 mg/L 3compartmentss NA 50% Human Human -DTXSID5029265 Css NA 0.6386 mg/L 3compartmentss NA 95% Human Human -DTXSID5029265 Css NA 0.06478 mg/L PBTK NA 50% Human Human -DTXSID5029265 Css NA 0.4263 mg/L PBTK NA 95% Human Human -DTXSID5029265 Clint NA 21.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029265 Fup NA 0.2526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029265 Vd NA 0.9282 L/kg 1compartment NA NA Rat Human +DTXSID5029265 TK.Half.Life NA 3.164 hours 1compartment NA NA Human Human +DTXSID5029265 Css NA 0.3386 mg/L 3compartmentss NA 50% Human Human +DTXSID5029265 Css NA 1.944 mg/L 3compartmentss NA 95% Human Human +DTXSID5029265 Css NA 0.2362 mg/L PBTK NA 50% Human Human +DTXSID5029265 Css NA 1.267 mg/L PBTK NA 95% Human Human +DTXSID5029265 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029265 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029265 Vd NA 0.7694 L/kg 1compartment NA NA Rat Human DTXSID5029265 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5029265 TK.Half.Life NA 0.7023 hours 1compartment NA NA Rat Human -DTXSID5029265 Css NA 0.04888 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029265 Css NA 0.2643 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029265 Css NA 0.03409 mg/L PBTK NA 50% Rat Human -DTXSID5029265 Css NA 0.1677 mg/L PBTK NA 95% Rat Human -DTXSID5029267 Clint NA 39.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029267 Fup NA 0.0488 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029267 Vd NA 1.122 L/kg 1compartment NA NA Human Human -DTXSID5029267 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5029267 TK.Half.Life NA 3.25 hours 1compartment NA NA Human Human -DTXSID5029267 Css NA 0.3538 mg/L 3compartmentss NA 50% Human Human -DTXSID5029267 Css NA 3.063 mg/L 3compartmentss NA 95% Human Human -DTXSID5029267 Css NA 0.2228 mg/L PBTK NA 50% Human Human -DTXSID5029267 Css NA 1.836 mg/L PBTK NA 95% Human Human -DTXSID5029267 Clint NA 39.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029267 Fup NA 0.0488 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029267 Vd NA 0.8507 L/kg 1compartment NA NA Rat Human -DTXSID5029267 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5029267 TK.Half.Life NA 1.352 hours 1compartment NA NA Rat Human -DTXSID5029267 Css NA 0.1994 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029267 Css NA 1.315 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029267 Css NA 0.1172 mg/L PBTK NA 50% Rat Human -DTXSID5029267 Css NA 0.7469 mg/L PBTK NA 95% Rat Human -DTXSID5029683 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029683 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029683 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID5029683 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5029683 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID5029683 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID5029683 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID5029683 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID5029683 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID5029683 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029683 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029683 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human -DTXSID5029683 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5029683 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID5029683 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029683 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029683 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID5029683 Css NA 1.296 mg/L PBTK NA 95% Rat Human -DTXSID5029710 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029710 Fup NA 0.6271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029710 Vd NA 1.16 L/kg 1compartment NA NA Human Human -DTXSID5029710 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5029710 TK.Half.Life NA 12.84 hours 1compartment NA NA Human Human -DTXSID5029710 Css NA 1.156 mg/L 3compartmentss NA 50% Human Human -DTXSID5029710 Css NA 8.083 mg/L 3compartmentss NA 95% Human Human -DTXSID5029710 Css NA 0.989 mg/L PBTK NA 50% Human Human -DTXSID5029710 Css NA 5.287 mg/L PBTK NA 95% Human Human -DTXSID5029710 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029710 Fup NA 0.6271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029710 Vd NA 1.057 L/kg 1compartment NA NA Rat Human -DTXSID5029710 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5029710 TK.Half.Life NA 3.781 hours 1compartment NA NA Rat Human -DTXSID5029710 Css NA 0.3049 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029710 Css NA 1.948 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029710 Css NA 0.2539 mg/L PBTK NA 50% Rat Human -DTXSID5029710 Css NA 1.175 mg/L PBTK NA 95% Rat Human -DTXSID5029762 Clint NA 0.7337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029762 Fup NA 0.0093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5029762 Vd NA 0.2195 L/kg 1compartment NA NA Human Human -DTXSID5029762 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID5029762 TK.Half.Life NA 67.89 hours 1compartment NA NA Human Human -DTXSID5029762 Css NA 53.65 mg/L 3compartmentss NA 50% Human Human -DTXSID5029762 Css NA 367.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5029762 Css NA 31.54 mg/L PBTK NA 50% Human Human -DTXSID5029762 Css NA 210.9 mg/L PBTK NA 95% Human Human -DTXSID5029762 Clint NA 0.7337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029762 Fup NA 0.0093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5029762 Vd NA 0.2036 L/kg 1compartment NA NA Rat Human -DTXSID5029762 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5029762 TK.Half.Life NA 30.01 hours 1compartment NA NA Rat Human -DTXSID5029762 Css NA 21.53 mg/L 3compartmentss NA 50% Rat Human -DTXSID5029762 Css NA 127.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID5029762 Css NA 11.81 mg/L PBTK NA 50% Rat Human -DTXSID5029762 Css NA 68.98 mg/L PBTK NA 95% Rat Human -DTXSID5030030 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5030030 Fup 0.01933 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5030030 Vd NA 0.2492 L/kg 1compartment NA NA Human Human -DTXSID5030030 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID5030030 TK.Half.Life NA 83.4 hours 1compartment NA NA Human Human -DTXSID5030030 Css NA 56.45 mg/L 3compartmentss NA 50% Human Human -DTXSID5030030 Css NA 352.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5030030 Css NA 33.61 mg/L PBTK NA 50% Human Human -DTXSID5030030 Css NA 204.8 mg/L PBTK NA 95% Human Human -DTXSID5030030 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5030030 Fup 0.01933 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5030030 Vd NA 0.2424 L/kg 1compartment NA NA Rat Human -DTXSID5030030 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5030030 TK.Half.Life NA 27.65 hours 1compartment NA NA Rat Human -DTXSID5030030 Css NA 16.25 mg/L 3compartmentss NA 50% Rat Human -DTXSID5030030 Css NA 85.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID5030030 Css NA 9.041 mg/L PBTK NA 50% Rat Human -DTXSID5030030 Css NA 46.66 mg/L PBTK NA 95% Rat Human +DTXSID5029265 TK.Half.Life NA 1.492 hours 1compartment NA NA Rat Human +DTXSID5029265 Css NA 0.03959 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029265 Css NA 0.1721 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029265 Css NA 0.02756 mg/L PBTK NA 50% Rat Human +DTXSID5029265 Css NA 0.1084 mg/L PBTK NA 95% Rat Human +DTXSID5029762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029762 Fup 0.0445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5029762 Vd NA 0.4181 L/kg 1compartment NA NA Human Human +DTXSID5029762 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5029762 TK.Half.Life NA 1.957 hours 1compartment NA NA Human Human +DTXSID5029762 Css NA 0.6618 mg/L 3compartmentss NA 50% Human Human +DTXSID5029762 Css NA 5.744 mg/L 3compartmentss NA 95% Human Human +DTXSID5029762 Css NA 0.4102 mg/L PBTK NA 50% Human Human +DTXSID5029762 Css NA 3.439 mg/L PBTK NA 95% Human Human +DTXSID5029762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029762 Fup 0.0445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5029762 Vd NA 0.3682 L/kg 1compartment NA NA Rat Human +DTXSID5029762 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5029762 TK.Half.Life NA 1.082 hours 1compartment NA NA Rat Human +DTXSID5029762 Css NA 0.08678 mg/L 3compartmentss NA 50% Rat Human +DTXSID5029762 Css NA 0.5917 mg/L 3compartmentss NA 95% Rat Human +DTXSID5029762 Css NA 0.0523 mg/L PBTK NA 50% Rat Human +DTXSID5029762 Css NA 0.3417 mg/L PBTK NA 95% Rat Human +DTXSID5030955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5030955 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5030955 Vd NA 1.698 L/kg 1compartment NA NA Human Human +DTXSID5030955 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5030955 TK.Half.Life NA 2.769 hours 1compartment NA NA Human Human +DTXSID5030955 Css NA 0.1074 mg/L 3compartmentss NA 50% Human Human +DTXSID5030955 Css NA 0.7141 mg/L 3compartmentss NA 95% Human Human +DTXSID5030955 Css NA 0.07867 mg/L PBTK NA 50% Human Human +DTXSID5030955 Css NA 0.4953 mg/L PBTK NA 95% Human Human +DTXSID5030955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5030955 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5030955 Vd 3 1.338 L/kg 1compartment National Toxicology Program NA Rat Human +DTXSID5030955 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5030955 TK.Half.Life 0.18 1.039 hours 1compartment National Toxicology Program NA Rat Human +DTXSID5030955 Css 0.0036 0.01321 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID5030955 Css 0.0036 0.06809 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID5030955 Css 0.0036 0.009702 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID5030955 Css 0.0036 0.04741 mg/L PBTK National Toxicology Program 95% Rat Human DTXSID5031131 Clint 301 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5031131 Fup 0.0986 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5031131 Vd NA 3.133 L/kg 1compartment NA NA Human Human DTXSID5031131 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5031131 TK.Half.Life NA 8.486 hours 1compartment NA NA Human Human -DTXSID5031131 Css NA 0.2347 mg/L 3compartmentss NA 50% Human Human -DTXSID5031131 Css NA 1.725 mg/L 3compartmentss NA 95% Human Human -DTXSID5031131 Css NA 0.1632 mg/L PBTK NA 50% Human Human -DTXSID5031131 Css NA 1.184 mg/L PBTK NA 95% Human Human +DTXSID5031131 Css NA 0.2253 mg/L 3compartmentss NA 50% Human Human +DTXSID5031131 Css NA 1.751 mg/L 3compartmentss NA 95% Human Human +DTXSID5031131 Css NA 0.1567 mg/L PBTK NA 50% Human Human +DTXSID5031131 Css NA 1.187 mg/L PBTK NA 95% Human Human DTXSID5031131 Clint 301 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5031131 Fup 0.0986 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5031131 Vd NA 2.347 L/kg 1compartment NA NA Rat Human DTXSID5031131 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5031131 TK.Half.Life NA 1.592 hours 1compartment NA NA Rat Human -DTXSID5031131 Css NA 0.1358 mg/L 3compartmentss NA 50% Rat Human -DTXSID5031131 Css NA 0.7767 mg/L 3compartmentss NA 95% Rat Human -DTXSID5031131 Css NA 0.09069 mg/L PBTK NA 50% Rat Human -DTXSID5031131 Css NA 0.499 mg/L PBTK NA 95% Rat Human +DTXSID5031131 Css NA 0.03014 mg/L 3compartmentss NA 50% Rat Human +DTXSID5031131 Css NA 0.1814 mg/L 3compartmentss NA 95% Rat Human +DTXSID5031131 Css NA 0.02091 mg/L PBTK NA 50% Rat Human +DTXSID5031131 Css NA 0.12 mg/L PBTK NA 95% Rat Human DTXSID5031133 Clint 858 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5031133 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5031133 Vd NA 1.98 L/kg 1compartment NA NA Human Human +DTXSID5031133 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5031133 Vd NA 2.419 L/kg 1compartment NA NA Human Human DTXSID5031133 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5031133 TK.Half.Life NA 1.86 hours 1compartment NA NA Human Human -DTXSID5031133 Css NA 0.01488 mg/L 3compartmentss NA 50% Human Human -DTXSID5031133 Css NA 0.1115 mg/L 3compartmentss NA 95% Human Human -DTXSID5031133 Css NA 0.00982 mg/L PBTK NA 50% Human Human -DTXSID5031133 Css NA 0.07096 mg/L PBTK NA 95% Human Human +DTXSID5031133 TK.Half.Life NA 2.104 hours 1compartment NA NA Human Human +DTXSID5031133 Css NA 0.007536 mg/L 3compartmentss NA 50% Human Human +DTXSID5031133 Css NA 0.0662 mg/L 3compartmentss NA 95% Human Human +DTXSID5031133 Css NA 0.005239 mg/L PBTK NA 50% Human Human +DTXSID5031133 Css NA 0.04443 mg/L PBTK NA 95% Human Human DTXSID5031133 Clint 858 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5031133 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5031133 Vd NA 1.488 L/kg 1compartment NA NA Rat Human +DTXSID5031133 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5031133 Vd NA 1.831 L/kg 1compartment NA NA Rat Human DTXSID5031133 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5031133 TK.Half.Life NA 0.6123 hours 1compartment NA NA Rat Human -DTXSID5031133 Css NA 0.008422 mg/L 3compartmentss NA 50% Rat Human -DTXSID5031133 Css NA 0.05189 mg/L 3compartmentss NA 95% Rat Human -DTXSID5031133 Css NA 0.005258 mg/L PBTK NA 50% Rat Human -DTXSID5031133 Css NA 0.03145 mg/L PBTK NA 95% Rat Human -DTXSID5031210 Clint NA 1.522 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5031210 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5031210 Vd NA 2.148 L/kg 1compartment NA NA Human Human -DTXSID5031210 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5031210 TK.Half.Life NA 5.324 hours 1compartment NA NA Human Human -DTXSID5031210 Css NA 0.225 mg/L 3compartmentss NA 50% Human Human -DTXSID5031210 Css NA 1.692 mg/L 3compartmentss NA 95% Human Human -DTXSID5031210 Css NA 0.236 mg/L PBTK NA 50% Human Human -DTXSID5031210 Css NA 1.264 mg/L PBTK NA 95% Human Human -DTXSID5031210 Clint NA 1.522 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5031210 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5031210 Vd NA 2.161 L/kg 1compartment NA NA Rat Human +DTXSID5031133 TK.Half.Life NA 0.6829 hours 1compartment NA NA Rat Human +DTXSID5031133 Css NA 0.001024 mg/L 3compartmentss NA 50% Rat Human +DTXSID5031133 Css NA 0.007224 mg/L 3compartmentss NA 95% Rat Human +DTXSID5031133 Css NA 0.000709 mg/L PBTK NA 50% Rat Human +DTXSID5031133 Css NA 0.004911 mg/L PBTK NA 95% Rat Human +DTXSID5031210 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5031210 Fup 0.437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5031210 Vd NA 1.402 L/kg 1compartment NA NA Human Human +DTXSID5031210 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5031210 TK.Half.Life NA 20.75 hours 1compartment NA NA Human Human +DTXSID5031210 Css NA 1.202 mg/L 3compartmentss NA 50% Human Human +DTXSID5031210 Css NA 6.019 mg/L 3compartmentss NA 95% Human Human +DTXSID5031210 Css NA 1.053 mg/L PBTK NA 50% Human Human +DTXSID5031210 Css NA 4.12 mg/L PBTK NA 95% Human Human +DTXSID5031210 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5031210 Fup 0.437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5031210 Vd NA 1.4 L/kg 1compartment NA NA Rat Human DTXSID5031210 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5031210 TK.Half.Life NA 2.748 hours 1compartment NA NA Rat Human -DTXSID5031210 Css NA 0.08858 mg/L 3compartmentss NA 50% Rat Human -DTXSID5031210 Css NA 0.6797 mg/L 3compartmentss NA 95% Rat Human -DTXSID5031210 Css NA 0.09317 mg/L PBTK NA 50% Rat Human -DTXSID5031210 Css NA 0.4535 mg/L PBTK NA 95% Rat Human -DTXSID5031428 Clint NA 72.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5031428 Fup NA 0.2112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5031428 Vd NA 1.259 L/kg 1compartment NA NA Human Human -DTXSID5031428 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5031428 TK.Half.Life NA 1.226 hours 1compartment NA NA Human Human -DTXSID5031428 Css NA 0.02923 mg/L 3compartmentss NA 50% Human Human -DTXSID5031428 Css NA 0.2247 mg/L 3compartmentss NA 95% Human Human -DTXSID5031428 Css NA 0.0221 mg/L PBTK NA 50% Human Human -DTXSID5031428 Css NA 0.1579 mg/L PBTK NA 95% Human Human -DTXSID5031428 Clint NA 72.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5031428 Fup NA 0.2112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5031428 Vd NA 1.193 L/kg 1compartment NA NA Rat Human -DTXSID5031428 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5031428 TK.Half.Life NA 0.5724 hours 1compartment NA NA Rat Human -DTXSID5031428 Css NA 0.01635 mg/L 3compartmentss NA 50% Rat Human -DTXSID5031428 Css NA 0.0946 mg/L 3compartmentss NA 95% Rat Human -DTXSID5031428 Css NA 0.01187 mg/L PBTK NA 50% Rat Human -DTXSID5031428 Css NA 0.06291 mg/L PBTK NA 95% Rat Human -DTXSID5032020 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032020 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032020 Vd NA 0.6276 L/kg 1compartment NA NA Human Human +DTXSID5031210 TK.Half.Life NA 7.063 hours 1compartment NA NA Rat Human +DTXSID5031210 Css NA 0.02162 mg/L 3compartmentss NA 50% Rat Human +DTXSID5031210 Css NA 0.1568 mg/L 3compartmentss NA 95% Rat Human +DTXSID5031210 Css NA 0.01865 mg/L PBTK NA 50% Rat Human +DTXSID5031210 Css NA 0.1113 mg/L PBTK NA 95% Rat Human +DTXSID50313051 Clint 5.75 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50313051 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50313051 Vd NA 0.6422 L/kg 1compartment NA NA Human Human +DTXSID50313051 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50313051 TK.Half.Life NA 2.383 hours 1compartment NA NA Human Human +DTXSID50313051 Css NA 0.3744 mg/L 3compartmentss NA 50% Human Human +DTXSID50313051 Css NA 2.198 mg/L 3compartmentss NA 95% Human Human +DTXSID50313051 Css NA 0.2546 mg/L PBTK NA 50% Human Human +DTXSID50313051 Css NA 1.416 mg/L PBTK NA 95% Human Human +DTXSID50313051 Clint 5.75 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50313051 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50313051 Vd NA 0.5743 L/kg 1compartment NA NA Rat Human +DTXSID50313051 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50313051 TK.Half.Life NA 1.232 hours 1compartment NA NA Rat Human +DTXSID50313051 Css NA 0.04433 mg/L 3compartmentss NA 50% Rat Human +DTXSID50313051 Css NA 0.1843 mg/L 3compartmentss NA 95% Rat Human +DTXSID50313051 Css NA 0.02978 mg/L PBTK NA 50% Rat Human +DTXSID50313051 Css NA 0.1145 mg/L PBTK NA 95% Rat Human +DTXSID5032020 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5032020 Fup 0.598 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5032020 Vd NA 0.4776 L/kg 1compartment NA NA Human Human DTXSID5032020 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5032020 TK.Half.Life NA 4.065 hours 1compartment NA NA Human Human -DTXSID5032020 Css NA 0.8864 mg/L 3compartmentss NA 50% Human Human -DTXSID5032020 Css NA 5.609 mg/L 3compartmentss NA 95% Human Human -DTXSID5032020 Css NA 0.7004 mg/L PBTK NA 50% Human Human -DTXSID5032020 Css NA 3.55 mg/L PBTK NA 95% Human Human -DTXSID5032020 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032020 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032020 Vd NA 0.6441 L/kg 1compartment NA NA Rat Human +DTXSID5032020 TK.Half.Life NA 5.173 hours 1compartment NA NA Human Human +DTXSID5032020 Css NA 0.7275 mg/L 3compartmentss NA 50% Human Human +DTXSID5032020 Css NA 4.924 mg/L 3compartmentss NA 95% Human Human +DTXSID5032020 Css NA 0.5355 mg/L PBTK NA 50% Human Human +DTXSID5032020 Css NA 3.035 mg/L PBTK NA 95% Human Human +DTXSID5032020 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5032020 Fup 0.598 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5032020 Vd NA 0.4876 L/kg 1compartment NA NA Rat Human DTXSID5032020 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5032020 TK.Half.Life NA 1.42 hours 1compartment NA NA Rat Human -DTXSID5032020 Css NA 0.2245 mg/L 3compartmentss NA 50% Rat Human -DTXSID5032020 Css NA 1.346 mg/L 3compartmentss NA 95% Rat Human -DTXSID5032020 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID5032020 Css NA 0.7933 mg/L PBTK NA 95% Rat Human -DTXSID5032315 Clint NA 1.357 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032315 Fup NA 0.0241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032315 Vd NA 2.066 L/kg 1compartment NA NA Human Human -DTXSID5032315 Days.Css NA 48 Days PBTK NA NA Human Human -DTXSID5032315 TK.Half.Life NA 226.4 hours 1compartment NA NA Human Human -DTXSID5032315 Css NA 17.04 mg/L 3compartmentss NA 50% Human Human -DTXSID5032315 Css NA 90.15 mg/L 3compartmentss NA 95% Human Human -DTXSID5032315 Css NA 11.05 mg/L PBTK NA 50% Human Human -DTXSID5032315 Css NA 54.76 mg/L PBTK NA 95% Human Human -DTXSID5032315 Clint NA 1.357 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032315 Fup NA 0.0241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032315 Vd NA 1.538 L/kg 1compartment NA NA Rat Human -DTXSID5032315 Days.Css NA 20 Days PBTK NA NA Rat Human -DTXSID5032315 TK.Half.Life NA 59.45 hours 1compartment NA NA Rat Human -DTXSID5032315 Css NA 7.943 mg/L 3compartmentss NA 50% Rat Human -DTXSID5032315 Css NA 34.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID5032315 Css NA 4.857 mg/L PBTK NA 50% Rat Human -DTXSID5032315 Css NA 19.31 mg/L PBTK NA 95% Rat Human +DTXSID5032020 TK.Half.Life NA 1.798 hours 1compartment NA NA Rat Human +DTXSID5032020 Css NA 0.0039 mg/L 3compartmentss NA 50% Rat Human +DTXSID5032020 Css NA 0.026 mg/L 3compartmentss NA 95% Rat Human +DTXSID5032020 Css NA 0.002742 mg/L PBTK NA 50% Rat Human +DTXSID5032020 Css NA 0.01527 mg/L PBTK NA 95% Rat Human +DTXSID5032315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5032315 Fup 0.0487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5032315 Vd NA 2.98 L/kg 1compartment NA NA Human Human +DTXSID5032315 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5032315 TK.Half.Life NA 40.37 hours 1compartment NA NA Human Human +DTXSID5032315 Css NA 1.618 mg/L 3compartmentss NA 50% Human Human +DTXSID5032315 Css NA 10.62 mg/L 3compartmentss NA 95% Human Human +DTXSID5032315 Css NA 1.116 mg/L PBTK NA 50% Human Human +DTXSID5032315 Css NA 7.184 mg/L PBTK NA 95% Human Human +DTXSID5032315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5032315 Fup 0.0487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5032315 Vd NA 2.234 L/kg 1compartment NA NA Rat Human +DTXSID5032315 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5032315 TK.Half.Life NA 6.73 hours 1compartment NA NA Rat Human +DTXSID5032315 Css NA 0.2108 mg/L 3compartmentss NA 50% Rat Human +DTXSID5032315 Css NA 1.125 mg/L 3compartmentss NA 95% Rat Human +DTXSID5032315 Css NA 0.1434 mg/L PBTK NA 50% Rat Human +DTXSID5032315 Css NA 0.755 mg/L PBTK NA 95% Rat Human DTXSID5032361 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5032361 Fup NA 0.9465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5032361 Vd NA 1.218 L/kg 1compartment NA NA Human Human DTXSID5032361 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5032361 TK.Half.Life NA 8.707 hours 1compartment NA NA Human Human -DTXSID5032361 Css NA 0.7948 mg/L 3compartmentss NA 50% Human Human -DTXSID5032361 Css NA 2.834 mg/L 3compartmentss NA 95% Human Human -DTXSID5032361 Css NA 0.7294 mg/L PBTK NA 50% Human Human -DTXSID5032361 Css NA 2.087 mg/L PBTK NA 95% Human Human +DTXSID5032361 Css NA 0.773 mg/L 3compartmentss NA 50% Human Human +DTXSID5032361 Css NA 2.86 mg/L 3compartmentss NA 95% Human Human +DTXSID5032361 Css NA 0.7098 mg/L PBTK NA 50% Human Human +DTXSID5032361 Css NA 2.099 mg/L PBTK NA 95% Human Human DTXSID5032361 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5032361 Fup NA 0.9465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5032361 Vd NA 1.163 L/kg 1compartment NA NA Rat Human DTXSID5032361 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5032361 TK.Half.Life NA 2.739 hours 1compartment NA NA Rat Human -DTXSID5032361 Css NA 0.204 mg/L 3compartmentss NA 50% Rat Human -DTXSID5032361 Css NA 0.6788 mg/L 3compartmentss NA 95% Rat Human -DTXSID5032361 Css NA 0.184 mg/L PBTK NA 50% Rat Human -DTXSID5032361 Css NA 0.464 mg/L PBTK NA 95% Rat Human +DTXSID5032361 Css NA 0.04573 mg/L 3compartmentss NA 50% Rat Human +DTXSID5032361 Css NA 0.1532 mg/L 3compartmentss NA 95% Rat Human +DTXSID5032361 Css NA 0.04278 mg/L PBTK NA 50% Rat Human +DTXSID5032361 Css NA 0.1084 mg/L PBTK NA 95% Rat Human DTXSID5032365 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5032365 Fup 0.06222 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5032365 Vd NA 1.226 L/kg 1compartment NA NA Human Human DTXSID5032365 Days.Css NA 35 Days PBTK NA NA Human Human DTXSID5032365 TK.Half.Life NA 159.3 hours 1compartment NA NA Human Human -DTXSID5032365 Css NA 17.59 mg/L 3compartmentss NA 50% Human Human -DTXSID5032365 Css NA 77.69 mg/L 3compartmentss NA 95% Human Human -DTXSID5032365 Css NA 12.74 mg/L PBTK NA 50% Human Human -DTXSID5032365 Css NA 49.35 mg/L PBTK NA 95% Human Human +DTXSID5032365 Css NA 15.55 mg/L 3compartmentss NA 50% Human Human +DTXSID5032365 Css NA 62.11 mg/L 3compartmentss NA 95% Human Human +DTXSID5032365 Css NA 12.24 mg/L PBTK NA 50% Human Human +DTXSID5032365 Css NA 48.9 mg/L PBTK NA 95% Human Human DTXSID5032365 Clint 9.822 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5032365 Fup 0.08402 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5032365 Vd NA 1.079 L/kg 1compartment NA NA Rat Rat DTXSID5032365 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID5032365 TK.Half.Life NA 3.211 hours 1compartment NA NA Rat Rat -DTXSID5032365 Css NA 0.3956 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5032365 Css NA 2.068 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5032365 Css NA 0.2712 mg/L PBTK NA 50% Rat Rat -DTXSID5032365 Css NA 1.274 mg/L PBTK NA 95% Rat Rat +DTXSID5032365 Css NA 0.07736 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5032365 Css NA 0.3673 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5032365 Css NA 0.06307 mg/L PBTK NA 50% Rat Rat +DTXSID5032365 Css NA 0.2994 mg/L PBTK NA 95% Rat Rat DTXSID5032442 Clint 2.807 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5032442 Fup 0.6559 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5032442 Vd NA 0.8723 L/kg 1compartment NA NA Human Human DTXSID5032442 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5032442 TK.Half.Life NA 1.902 hours 1compartment NA NA Human Human -DTXSID5032442 Css NA 0.208 mg/L 3compartmentss NA 50% Human Human -DTXSID5032442 Css NA 1.689 mg/L 3compartmentss NA 95% Human Human -DTXSID5032442 Css NA 0.174 mg/L PBTK NA 50% Human Human -DTXSID5032442 Css NA 1.117 mg/L PBTK NA 95% Human Human +DTXSID5032442 Css NA 0.1931 mg/L 3compartmentss NA 50% Human Human +DTXSID5032442 Css NA 1.253 mg/L 3compartmentss NA 95% Human Human +DTXSID5032442 Css NA 0.1662 mg/L PBTK NA 50% Human Human +DTXSID5032442 Css NA 1.082 mg/L PBTK NA 95% Human Human DTXSID5032442 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5032442 Fup 0.8393 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID5032442 Vd NA 0.9894 L/kg 1compartment NA NA Rat Rat +DTXSID5032442 Vd 2.9 0.9894 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID5032442 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID5032442 TK.Half.Life NA 2.613 hours 1compartment NA NA Rat Rat -DTXSID5032442 Css NA 0.253 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5032442 Css NA 1.488 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5032442 Css NA 0.2004 mg/L PBTK NA 50% Rat Rat -DTXSID5032442 Css NA 0.8884 mg/L PBTK NA 95% Rat Rat +DTXSID5032442 TK.Half.Life 9.5 2.613 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID5032442 Css 0.2 0.05228 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID5032442 Css 0.2 0.2191 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID5032442 Css 0.2 0.04692 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID5032442 Css 0.2 0.1967 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID5032498 Clint 27.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5032498 Fup 0.00428 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5032498 Vd NA 2.325 L/kg 1compartment NA NA Human Human DTXSID5032498 Days.Css NA 6 Days PBTK NA NA Human Human DTXSID5032498 TK.Half.Life NA 44.95 hours 1compartment NA NA Human Human -DTXSID5032498 Css NA 2.585 mg/L 3compartmentss NA 50% Human Human -DTXSID5032498 Css NA 16.43 mg/L 3compartmentss NA 95% Human Human -DTXSID5032498 Css NA 1.585 mg/L PBTK NA 50% Human Human -DTXSID5032498 Css NA 9.794 mg/L PBTK NA 95% Human Human +DTXSID5032498 Css NA 2.344 mg/L 3compartmentss NA 50% Human Human +DTXSID5032498 Css NA 15.52 mg/L 3compartmentss NA 95% Human Human +DTXSID5032498 Css NA 1.508 mg/L PBTK NA 50% Human Human +DTXSID5032498 Css NA 9.988 mg/L PBTK NA 95% Human Human DTXSID5032498 Clint 34.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5032498 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID5032498 Css NA 1.353 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5032498 Css NA 8.426 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5032498 Css 0.004 0.2689 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID5032498 Css 0.004 1.738 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat DTXSID5032523 Clint 34.74 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID5032523 Fup NA 0.3368 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032523 Vd NA 0.3651 L/kg 1compartment NA NA Human Human +DTXSID5032523 Fup 0.0841 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5032523 Vd NA 0.2213 L/kg 1compartment NA NA Human Human DTXSID5032523 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5032523 TK.Half.Life NA 0.4023 hours 1compartment NA NA Human Human -DTXSID5032523 Css NA 0.0419 mg/L 3compartmentss NA 50% Human Human -DTXSID5032523 Css NA 0.3145 mg/L 3compartmentss NA 95% Human Human -DTXSID5032523 Css NA 0.02856 mg/L PBTK NA 50% Human Human -DTXSID5032523 Css NA 0.1998 mg/L PBTK NA 95% Human Human +DTXSID5032523 TK.Half.Life NA 0.4899 hours 1compartment NA NA Human Human +DTXSID5032523 Css NA 0.2265 mg/L 3compartmentss NA 50% Human Human +DTXSID5032523 Css NA 1.902 mg/L 3compartmentss NA 95% Human Human +DTXSID5032523 Css NA 0.136 mg/L PBTK NA 50% Human Human +DTXSID5032523 Css NA 1.133 mg/L PBTK NA 95% Human Human DTXSID5032523 Clint 34.74 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID5032523 Fup NA 0.3368 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032523 Vd NA 0.3694 L/kg 1compartment NA NA Rat Human +DTXSID5032523 Fup 0.0841 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5032523 Vd NA 0.2213 L/kg 1compartment NA NA Rat Human DTXSID5032523 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5032523 TK.Half.Life NA 0.203 hours 1compartment NA NA Rat Human -DTXSID5032523 Css NA 0.02286 mg/L 3compartmentss NA 50% Rat Human -DTXSID5032523 Css NA 0.1387 mg/L 3compartmentss NA 95% Rat Human -DTXSID5032523 Css NA 0.01474 mg/L PBTK NA 50% Rat Human -DTXSID5032523 Css NA 0.08303 mg/L PBTK NA 95% Rat Human +DTXSID5032523 TK.Half.Life NA 0.2841 hours 1compartment NA NA Rat Human +DTXSID5032523 Css NA 0.03009 mg/L 3compartmentss NA 50% Rat Human +DTXSID5032523 Css NA 0.1831 mg/L 3compartmentss NA 95% Rat Human +DTXSID5032523 Css NA 0.01756 mg/L PBTK NA 50% Rat Human +DTXSID5032523 Css NA 0.1038 mg/L PBTK NA 95% Rat Human DTXSID5032525 Clint 41.15 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5032525 Fup 0.836 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID5032525 Vd NA 3.066 L/kg 1compartment NA NA Human Human +DTXSID5032525 Vd NA 3.107 L/kg 1compartment NA NA Human Human DTXSID5032525 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5032525 TK.Half.Life NA 4.731 hours 1compartment NA NA Human Human -DTXSID5032525 Css NA 0.09726 mg/L 3compartmentss NA 50% Human Human -DTXSID5032525 Css NA 0.6742 mg/L 3compartmentss NA 95% Human Human -DTXSID5032525 Css NA 0.07445 mg/L PBTK NA 50% Human Human -DTXSID5032525 Css NA 0.4751 mg/L PBTK NA 95% Human Human +DTXSID5032525 TK.Half.Life NA 6.15 hours 1compartment NA NA Human Human +DTXSID5032525 Css NA 0.1414 mg/L 3compartmentss NA 50% Human Human +DTXSID5032525 Css NA 0.9519 mg/L 3compartmentss NA 95% Human Human +DTXSID5032525 Css NA 0.1058 mg/L PBTK NA 50% Human Human +DTXSID5032525 Css NA 0.6797 mg/L PBTK NA 95% Human Human DTXSID5032525 Clint 41.15 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID5032525 Fup 0.836 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID5032525 Vd NA 2.348 L/kg 1compartment NA NA Rat Human +DTXSID5032525 Vd NA 2.363 L/kg 1compartment NA NA Rat Human DTXSID5032525 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5032525 TK.Half.Life NA 1.122 hours 1compartment NA NA Rat Human -DTXSID5032525 Css NA 0.0536 mg/L 3compartmentss NA 50% Rat Human -DTXSID5032525 Css NA 0.3152 mg/L 3compartmentss NA 95% Rat Human -DTXSID5032525 Css NA 0.03976 mg/L PBTK NA 50% Rat Human -DTXSID5032525 Css NA 0.222 mg/L PBTK NA 95% Rat Human -DTXSID5032573 Clint 63.93 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID5032573 Fup NA 0.013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032573 Vd NA 5.56 L/kg 1compartment NA NA Human Human -DTXSID5032573 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID5032573 TK.Half.Life NA 59.34 hours 1compartment NA NA Human Human -DTXSID5032573 Css NA 0.971 mg/L 3compartmentss NA 50% Human Human -DTXSID5032573 Css NA 5.767 mg/L 3compartmentss NA 95% Human Human -DTXSID5032573 Css NA 0.8226 mg/L PBTK NA 50% Human Human -DTXSID5032573 Css NA 4.84 mg/L PBTK NA 95% Human Human -DTXSID5032573 Clint 63.93 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID5032573 Fup NA 0.013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032573 Vd NA 4.266 L/kg 1compartment NA NA Rat Human -DTXSID5032573 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID5032573 TK.Half.Life NA 8.618 hours 1compartment NA NA Rat Human -DTXSID5032573 Css NA 0.5453 mg/L 3compartmentss NA 50% Rat Human -DTXSID5032573 Css NA 2.272 mg/L 3compartmentss NA 95% Rat Human -DTXSID5032573 Css NA 0.4478 mg/L PBTK NA 50% Rat Human -DTXSID5032573 Css NA 1.839 mg/L PBTK NA 95% Rat Human +DTXSID5032525 TK.Half.Life NA 1.314 hours 1compartment NA NA Rat Human +DTXSID5032525 Css NA 0.01804 mg/L 3compartmentss NA 50% Rat Human +DTXSID5032525 Css NA 0.0955 mg/L 3compartmentss NA 95% Rat Human +DTXSID5032525 Css NA 0.0135 mg/L PBTK NA 50% Rat Human +DTXSID5032525 Css NA 0.06746 mg/L PBTK NA 95% Rat Human DTXSID5032577 Clint 24.81 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID5032577 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032577 Vd NA 6.798 L/kg 1compartment NA NA Human Human +DTXSID5032577 Fup 0.00811 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5032577 Vd NA 6.828 L/kg 1compartment NA NA Human Human DTXSID5032577 Days.Css NA 34 Days PBTK NA NA Human Human -DTXSID5032577 TK.Half.Life NA 181.5 hours 1compartment NA NA Human Human -DTXSID5032577 Css NA 2.314 mg/L 3compartmentss NA 50% Human Human -DTXSID5032577 Css NA 12.76 mg/L 3compartmentss NA 95% Human Human -DTXSID5032577 Css NA 2.168 mg/L PBTK NA 50% Human Human -DTXSID5032577 Css NA 11.75 mg/L PBTK NA 95% Human Human +DTXSID5032577 TK.Half.Life NA 181.2 hours 1compartment NA NA Human Human +DTXSID5032577 Css NA 2.245 mg/L 3compartmentss NA 50% Human Human +DTXSID5032577 Css NA 13.32 mg/L 3compartmentss NA 95% Human Human +DTXSID5032577 Css NA 2.096 mg/L PBTK NA 50% Human Human +DTXSID5032577 Css NA 12.43 mg/L PBTK NA 95% Human Human DTXSID5032577 Clint 24.81 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID5032577 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032577 Vd NA 5.261 L/kg 1compartment NA NA Rat Human +DTXSID5032577 Fup 0.00811 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5032577 Vd NA 5.285 L/kg 1compartment NA NA Rat Human DTXSID5032577 Days.Css NA 20 Days PBTK NA NA Rat Human -DTXSID5032577 TK.Half.Life NA 25.95 hours 1compartment NA NA Rat Human -DTXSID5032577 Css NA 1.284 mg/L 3compartmentss NA 50% Rat Human -DTXSID5032577 Css NA 5.659 mg/L 3compartmentss NA 95% Rat Human -DTXSID5032577 Css NA 1.184 mg/L PBTK NA 50% Rat Human -DTXSID5032577 Css NA 5.18 mg/L PBTK NA 95% Rat Human +DTXSID5032577 TK.Half.Life NA 25.51 hours 1compartment NA NA Rat Human +DTXSID5032577 Css NA 0.2862 mg/L 3compartmentss NA 50% Rat Human +DTXSID5032577 Css NA 1.407 mg/L 3compartmentss NA 95% Rat Human +DTXSID5032577 Css NA 0.2737 mg/L PBTK NA 50% Rat Human +DTXSID5032577 Css NA 1.367 mg/L PBTK NA 95% Rat Human DTXSID5032579 Clint 858 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5032579 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032579 Vd NA 1.228 L/kg 1compartment NA NA Human Human +DTXSID5032579 Fup 0.0272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5032579 Vd NA 1.677 L/kg 1compartment NA NA Human Human DTXSID5032579 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5032579 TK.Half.Life NA 1.336 hours 1compartment NA NA Human Human -DTXSID5032579 Css NA 0.03145 mg/L 3compartmentss NA 50% Human Human -DTXSID5032579 Css NA 0.2945 mg/L 3compartmentss NA 95% Human Human -DTXSID5032579 Css NA 0.01951 mg/L PBTK NA 50% Human Human -DTXSID5032579 Css NA 0.1774 mg/L PBTK NA 95% Human Human +DTXSID5032579 TK.Half.Life NA 1.779 hours 1compartment NA NA Human Human +DTXSID5032579 Css NA 0.02639 mg/L 3compartmentss NA 50% Human Human +DTXSID5032579 Css NA 0.2879 mg/L 3compartmentss NA 95% Human Human +DTXSID5032579 Css NA 0.01677 mg/L PBTK NA 50% Human Human +DTXSID5032579 Css NA 0.1727 mg/L PBTK NA 95% Human Human DTXSID5032579 Clint 858 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5032579 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032579 Vd NA 0.9152 L/kg 1compartment NA NA Rat Human +DTXSID5032579 Fup 0.0272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5032579 Vd NA 1.249 L/kg 1compartment NA NA Rat Human DTXSID5032579 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5032579 TK.Half.Life NA 0.4596 hours 1compartment NA NA Rat Human -DTXSID5032579 Css NA 0.01797 mg/L 3compartmentss NA 50% Rat Human -DTXSID5032579 Css NA 0.1483 mg/L 3compartmentss NA 95% Rat Human -DTXSID5032579 Css NA 0.01042 mg/L PBTK NA 50% Rat Human -DTXSID5032579 Css NA 0.08318 mg/L PBTK NA 95% Rat Human +DTXSID5032579 TK.Half.Life NA 0.5945 hours 1compartment NA NA Rat Human +DTXSID5032579 Css NA 0.003591 mg/L 3compartmentss NA 50% Rat Human +DTXSID5032579 Css NA 0.03015 mg/L 3compartmentss NA 95% Rat Human +DTXSID5032579 Css NA 0.002231 mg/L PBTK NA 50% Rat Human +DTXSID5032579 Css NA 0.01795 mg/L PBTK NA 95% Rat Human DTXSID5032600 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5032600 Fup 0.984 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID5032600 Vd NA 1.756 L/kg 1compartment NA NA Human Human -DTXSID5032600 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5032600 TK.Half.Life NA 11.58 hours 1compartment NA NA Human Human -DTXSID5032600 Css NA 1.184 mg/L 3compartmentss NA 50% Human Human -DTXSID5032600 Css NA 5.726 mg/L 3compartmentss NA 95% Human Human -DTXSID5032600 Css NA 0.7256 mg/L PBTK NA 50% Human Human -DTXSID5032600 Css NA 3.368 mg/L PBTK NA 95% Human Human +DTXSID5032600 Vd NA 2.206 L/kg 1compartment NA NA Human Human +DTXSID5032600 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5032600 TK.Half.Life NA 14.69 hours 1compartment NA NA Human Human +DTXSID5032600 Css NA 1.167 mg/L 3compartmentss NA 50% Human Human +DTXSID5032600 Css NA 5.488 mg/L 3compartmentss NA 95% Human Human +DTXSID5032600 Css NA 0.7073 mg/L PBTK NA 50% Human Human +DTXSID5032600 Css NA 3.325 mg/L PBTK NA 95% Human Human DTXSID5032600 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5032600 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID5032600 Css NA 60.65 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5032600 Css NA 333.9 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5032654 Clint NA 753.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032654 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5032654 Vd NA 0.4548 L/kg 1compartment NA NA Human Human -DTXSID5032654 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5032654 TK.Half.Life NA 0.4338 hours 1compartment NA NA Human Human -DTXSID5032654 Css NA 0.009132 mg/L 3compartmentss NA 50% Human Human -DTXSID5032654 Css NA 0.07849 mg/L 3compartmentss NA 95% Human Human -DTXSID5032654 Css NA 0.005656 mg/L PBTK NA 50% Human Human -DTXSID5032654 Css NA 0.04644 mg/L PBTK NA 95% Human Human -DTXSID5032654 Clint NA 753.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032654 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5032654 Vd NA 0.3892 L/kg 1compartment NA NA Rat Human +DTXSID5032600 Css 0.4 12.86 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID5032600 Css 0.4 67.65 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID5032654 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5032654 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5032654 Vd NA 0.7386 L/kg 1compartment NA NA Human Human +DTXSID5032654 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5032654 TK.Half.Life NA 20.22 hours 1compartment NA NA Human Human +DTXSID5032654 Css NA 3.082 mg/L 3compartmentss NA 50% Human Human +DTXSID5032654 Css NA 11.31 mg/L 3compartmentss NA 95% Human Human +DTXSID5032654 Css NA 2.151 mg/L PBTK NA 50% Human Human +DTXSID5032654 Css NA 7.158 mg/L PBTK NA 95% Human Human +DTXSID5032654 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5032654 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5032654 Vd NA 0.6311 L/kg 1compartment NA NA Rat Human DTXSID5032654 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5032654 TK.Half.Life NA 0.1673 hours 1compartment NA NA Rat Human -DTXSID5032654 Css NA 0.005277 mg/L 3compartmentss NA 50% Rat Human -DTXSID5032654 Css NA 0.03711 mg/L 3compartmentss NA 95% Rat Human -DTXSID5032654 Css NA 0.003079 mg/L PBTK NA 50% Rat Human -DTXSID5032654 Css NA 0.02124 mg/L PBTK NA 95% Rat Human -DTXSID5033096 Clint NA 0.4752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033096 Fup NA 0.5476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033096 Vd NA 0.4593 L/kg 1compartment NA NA Human Human +DTXSID5032654 TK.Half.Life NA 5.663 hours 1compartment NA NA Rat Human +DTXSID5032654 Css NA 0.1987 mg/L 3compartmentss NA 50% Rat Human +DTXSID5032654 Css NA 0.63 mg/L 3compartmentss NA 95% Rat Human +DTXSID5032654 Css NA 0.1369 mg/L PBTK NA 50% Rat Human +DTXSID5032654 Css NA 0.3818 mg/L PBTK NA 95% Rat Human +DTXSID5033096 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033096 Fup 0.7 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033096 Vd NA 0.4723 L/kg 1compartment NA NA Human Human DTXSID5033096 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5033096 TK.Half.Life NA 3.049 hours 1compartment NA NA Human Human -DTXSID5033096 Css NA 0.7708 mg/L 3compartmentss NA 50% Human Human -DTXSID5033096 Css NA 4.872 mg/L 3compartmentss NA 95% Human Human -DTXSID5033096 Css NA 0.5684 mg/L PBTK NA 50% Human Human -DTXSID5033096 Css NA 3.026 mg/L PBTK NA 95% Human Human -DTXSID5033096 Clint NA 0.4752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033096 Fup NA 0.5476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033096 Vd NA 0.4718 L/kg 1compartment NA NA Rat Human +DTXSID5033096 TK.Half.Life NA 4.365 hours 1compartment NA NA Human Human +DTXSID5033096 Css NA 0.6352 mg/L 3compartmentss NA 50% Human Human +DTXSID5033096 Css NA 4.184 mg/L 3compartmentss NA 95% Human Human +DTXSID5033096 Css NA 0.4768 mg/L PBTK NA 50% Human Human +DTXSID5033096 Css NA 2.595 mg/L PBTK NA 95% Human Human +DTXSID5033096 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033096 Fup 0.7 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033096 Vd NA 0.4932 L/kg 1compartment NA NA Rat Human DTXSID5033096 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5033096 TK.Half.Life NA 1.371 hours 1compartment NA NA Rat Human -DTXSID5033096 Css NA 0.27 mg/L 3compartmentss NA 50% Rat Human -DTXSID5033096 Css NA 1.56 mg/L 3compartmentss NA 95% Rat Human -DTXSID5033096 Css NA 0.1905 mg/L PBTK NA 50% Rat Human -DTXSID5033096 Css NA 0.8974 mg/L PBTK NA 95% Rat Human -DTXSID5033098 Clint NA 0.04402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033098 Fup NA 0.3802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033098 Vd NA 0.4048 L/kg 1compartment NA NA Human Human +DTXSID5033096 TK.Half.Life NA 1.553 hours 1compartment NA NA Rat Human +DTXSID5033096 Css NA 0.003393 mg/L 3compartmentss NA 50% Rat Human +DTXSID5033096 Css NA 0.0218 mg/L 3compartmentss NA 95% Rat Human +DTXSID5033096 Css NA 0.002454 mg/L PBTK NA 50% Rat Human +DTXSID5033096 Css NA 0.01297 mg/L PBTK NA 95% Rat Human +DTXSID5033098 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033098 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033098 Vd NA 0.5007 L/kg 1compartment NA NA Human Human DTXSID5033098 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5033098 TK.Half.Life NA 6.406 hours 1compartment NA NA Human Human -DTXSID5033098 Css NA 1.83 mg/L 3compartmentss NA 50% Human Human -DTXSID5033098 Css NA 7.727 mg/L 3compartmentss NA 95% Human Human -DTXSID5033098 Css NA 1.284 mg/L PBTK NA 50% Human Human -DTXSID5033098 Css NA 4.812 mg/L PBTK NA 95% Human Human -DTXSID5033098 Clint NA 0.04402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033098 Fup NA 0.3802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033098 Vd NA 0.4132 L/kg 1compartment NA NA Rat Human +DTXSID5033098 TK.Half.Life NA 6.145 hours 1compartment NA NA Human Human +DTXSID5033098 Css NA 1.387 mg/L 3compartmentss NA 50% Human Human +DTXSID5033098 Css NA 7.583 mg/L 3compartmentss NA 95% Human Human +DTXSID5033098 Css NA 1.045 mg/L PBTK NA 50% Human Human +DTXSID5033098 Css NA 4.754 mg/L PBTK NA 95% Human Human +DTXSID5033098 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033098 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033098 Vd NA 0.51 L/kg 1compartment NA NA Rat Human DTXSID5033098 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5033098 TK.Half.Life NA 2.311 hours 1compartment NA NA Rat Human -DTXSID5033098 Css NA 0.5247 mg/L 3compartmentss NA 50% Rat Human -DTXSID5033098 Css NA 1.94 mg/L 3compartmentss NA 95% Rat Human -DTXSID5033098 Css NA 0.3509 mg/L PBTK NA 50% Rat Human -DTXSID5033098 Css NA 1.128 mg/L PBTK NA 95% Rat Human +DTXSID5033098 TK.Half.Life NA 2.133 hours 1compartment NA NA Rat Human +DTXSID5033098 Css NA 0.08541 mg/L 3compartmentss NA 50% Rat Human +DTXSID5033098 Css NA 0.4572 mg/L 3compartmentss NA 95% Rat Human +DTXSID5033098 Css NA 0.06377 mg/L PBTK NA 50% Rat Human +DTXSID5033098 Css NA 0.2755 mg/L PBTK NA 95% Rat Human DTXSID5033179 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5033179 Fup NA 0.767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033179 Vd NA 0.6216 L/kg 1compartment NA NA Human Human +DTXSID5033179 Vd NA 0.6747 L/kg 1compartment NA NA Human Human DTXSID5033179 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5033179 TK.Half.Life NA 5.243 hours 1compartment NA NA Human Human -DTXSID5033179 Css NA 1.052 mg/L 3compartmentss NA 50% Human Human -DTXSID5033179 Css NA 6.233 mg/L 3compartmentss NA 95% Human Human -DTXSID5033179 Css NA 0.8422 mg/L PBTK NA 50% Human Human -DTXSID5033179 Css NA 3.958 mg/L PBTK NA 95% Human Human +DTXSID5033179 TK.Half.Life NA 5.691 hours 1compartment NA NA Human Human +DTXSID5033179 Css NA 0.8788 mg/L 3compartmentss NA 50% Human Human +DTXSID5033179 Css NA 5.459 mg/L 3compartmentss NA 95% Human Human +DTXSID5033179 Css NA 0.7174 mg/L PBTK NA 50% Human Human +DTXSID5033179 Css NA 3.516 mg/L PBTK NA 95% Human Human DTXSID5033179 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5033179 Fup NA 0.767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033179 Vd NA 0.6584 L/kg 1compartment NA NA Rat Human +DTXSID5033179 Vd NA 0.7051 L/kg 1compartment NA NA Rat Human DTXSID5033179 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5033179 TK.Half.Life NA 1.893 hours 1compartment NA NA Rat Human -DTXSID5033179 Css NA 0.2694 mg/L 3compartmentss NA 50% Rat Human -DTXSID5033179 Css NA 1.692 mg/L 3compartmentss NA 95% Rat Human -DTXSID5033179 Css NA 0.2076 mg/L PBTK NA 50% Rat Human -DTXSID5033179 Css NA 0.9951 mg/L PBTK NA 95% Rat Human -DTXSID5033389 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033389 Fup NA 0.0508 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033389 Vd NA 0.6978 L/kg 1compartment NA NA Human Human -DTXSID5033389 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID5033389 TK.Half.Life NA 95.55 hours 1compartment NA NA Human Human -DTXSID5033389 Css NA 22.04 mg/L 3compartmentss NA 50% Human Human -DTXSID5033389 Css NA 104.4 mg/L 3compartmentss NA 95% Human Human -DTXSID5033389 Css NA 13.6 mg/L PBTK NA 50% Human Human -DTXSID5033389 Css NA 61.7 mg/L PBTK NA 95% Human Human -DTXSID5033389 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033389 Fup NA 0.0508 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033389 Vd NA 0.5452 L/kg 1compartment NA NA Rat Human -DTXSID5033389 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5033389 TK.Half.Life NA 24.08 hours 1compartment NA NA Rat Human -DTXSID5033389 Css NA 6.23 mg/L 3compartmentss NA 50% Rat Human -DTXSID5033389 Css NA 25.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID5033389 Css NA 3.611 mg/L PBTK NA 50% Rat Human -DTXSID5033389 Css NA 14.02 mg/L PBTK NA 95% Rat Human -DTXSID5033468 Clint NA 127.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033468 Fup NA 0.4954 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033468 Vd NA 3.152 L/kg 1compartment NA NA Human Human -DTXSID5033468 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5033468 TK.Half.Life NA 16.09 hours 1compartment NA NA Human Human -DTXSID5033468 Css NA 0.5288 mg/L 3compartmentss NA 50% Human Human -DTXSID5033468 Css NA 3.294 mg/L 3compartmentss NA 95% Human Human -DTXSID5033468 Css NA 0.3715 mg/L PBTK NA 50% Human Human -DTXSID5033468 Css NA 2.254 mg/L PBTK NA 95% Human Human -DTXSID5033468 Clint NA 127.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033468 Fup NA 0.4954 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033468 Vd NA 2.368 L/kg 1compartment NA NA Rat Human +DTXSID5033179 TK.Half.Life NA 2.027 hours 1compartment NA NA Rat Human +DTXSID5033179 Css NA 0.01643 mg/L 3compartmentss NA 50% Rat Human +DTXSID5033179 Css NA 0.1296 mg/L 3compartmentss NA 95% Rat Human +DTXSID5033179 Css NA 0.01277 mg/L PBTK NA 50% Rat Human +DTXSID5033179 Css NA 0.08374 mg/L PBTK NA 95% Rat Human +DTXSID5033389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033389 Fup 0.0394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033389 Vd NA 0.5121 L/kg 1compartment NA NA Human Human +DTXSID5033389 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5033389 TK.Half.Life NA 2.634 hours 1compartment NA NA Human Human +DTXSID5033389 Css NA 0.7822 mg/L 3compartmentss NA 50% Human Human +DTXSID5033389 Css NA 7.52 mg/L 3compartmentss NA 95% Human Human +DTXSID5033389 Css NA 0.4734 mg/L PBTK NA 50% Human Human +DTXSID5033389 Css NA 4.445 mg/L PBTK NA 95% Human Human +DTXSID5033389 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033389 Fup 0.0394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033389 Vd NA 0.4095 L/kg 1compartment NA NA Rat Human +DTXSID5033389 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5033389 TK.Half.Life NA 1.31 hours 1compartment NA NA Rat Human +DTXSID5033389 Css NA 0.103 mg/L 3compartmentss NA 50% Rat Human +DTXSID5033389 Css NA 0.7632 mg/L 3compartmentss NA 95% Rat Human +DTXSID5033389 Css NA 0.06043 mg/L PBTK NA 50% Rat Human +DTXSID5033389 Css NA 0.435 mg/L PBTK NA 95% Rat Human +DTXSID5033468 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033468 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033468 Vd NA 1.124 L/kg 1compartment NA NA Human Human +DTXSID5033468 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5033468 TK.Half.Life NA 4.498 hours 1compartment NA NA Human Human +DTXSID5033468 Css NA 0.397 mg/L 3compartmentss NA 50% Human Human +DTXSID5033468 Css NA 2.384 mg/L 3compartmentss NA 95% Human Human +DTXSID5033468 Css NA 0.2864 mg/L PBTK NA 50% Human Human +DTXSID5033468 Css NA 1.566 mg/L PBTK NA 95% Human Human +DTXSID5033468 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033468 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033468 Vd NA 1.066 L/kg 1compartment NA NA Rat Human DTXSID5033468 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5033468 TK.Half.Life NA 2.549 hours 1compartment NA NA Rat Human -DTXSID5033468 Css NA 0.2958 mg/L 3compartmentss NA 50% Rat Human -DTXSID5033468 Css NA 1.523 mg/L 3compartmentss NA 95% Rat Human -DTXSID5033468 Css NA 0.1984 mg/L PBTK NA 50% Rat Human -DTXSID5033468 Css NA 0.986 mg/L PBTK NA 95% Rat Human -DTXSID5033595 Clint NA 49.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033595 Fup NA 0.1131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033595 Vd NA 0.9016 L/kg 1compartment NA NA Human Human +DTXSID5033468 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human +DTXSID5033468 Css NA 0.04782 mg/L 3compartmentss NA 50% Rat Human +DTXSID5033468 Css NA 0.2135 mg/L 3compartmentss NA 95% Rat Human +DTXSID5033468 Css NA 0.0341 mg/L PBTK NA 50% Rat Human +DTXSID5033468 Css NA 0.1368 mg/L PBTK NA 95% Rat Human +DTXSID5033595 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033595 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033595 Vd NA 1.28 L/kg 1compartment NA NA Human Human DTXSID5033595 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5033595 TK.Half.Life NA 1.392 hours 1compartment NA NA Human Human -DTXSID5033595 Css NA 0.1144 mg/L 3compartmentss NA 50% Human Human -DTXSID5033595 Css NA 0.9613 mg/L 3compartmentss NA 95% Human Human -DTXSID5033595 Css NA 0.07463 mg/L PBTK NA 50% Human Human -DTXSID5033595 Css NA 0.5874 mg/L PBTK NA 95% Human Human -DTXSID5033595 Clint NA 49.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033595 Fup NA 0.1131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033595 Vd NA 0.723 L/kg 1compartment NA NA Rat Human +DTXSID5033595 TK.Half.Life NA 2.616 hours 1compartment NA NA Human Human +DTXSID5033595 Css NA 0.1771 mg/L 3compartmentss NA 50% Human Human +DTXSID5033595 Css NA 1.341 mg/L 3compartmentss NA 95% Human Human +DTXSID5033595 Css NA 0.1204 mg/L PBTK NA 50% Human Human +DTXSID5033595 Css NA 0.8577 mg/L PBTK NA 95% Human Human +DTXSID5033595 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033595 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033595 Vd NA 1.009 L/kg 1compartment NA NA Rat Human DTXSID5033595 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5033595 TK.Half.Life NA 0.5869 hours 1compartment NA NA Rat Human -DTXSID5033595 Css NA 0.06456 mg/L 3compartmentss NA 50% Rat Human -DTXSID5033595 Css NA 0.4225 mg/L 3compartmentss NA 95% Rat Human -DTXSID5033595 Css NA 0.03964 mg/L PBTK NA 50% Rat Human -DTXSID5033595 Css NA 0.2452 mg/L PBTK NA 95% Rat Human -DTXSID5033674 Clint NA 560.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033674 Fup NA 0.1834 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033674 Vd NA 1.304 L/kg 1compartment NA NA Human Human +DTXSID5033595 TK.Half.Life NA 1.075 hours 1compartment NA NA Rat Human +DTXSID5033595 Css NA 0.02238 mg/L 3compartmentss NA 50% Rat Human +DTXSID5033595 Css NA 0.1347 mg/L 3compartmentss NA 95% Rat Human +DTXSID5033595 Css NA 0.01504 mg/L PBTK NA 50% Rat Human +DTXSID5033595 Css NA 0.08519 mg/L PBTK NA 95% Rat Human +DTXSID5033674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033674 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033674 Vd NA 1.369 L/kg 1compartment NA NA Human Human DTXSID5033674 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5033674 TK.Half.Life NA 1.083 hours 1compartment NA NA Human Human -DTXSID5033674 Css NA 0.005342 mg/L 3compartmentss NA 50% Human Human -DTXSID5033674 Css NA 0.04113 mg/L 3compartmentss NA 95% Human Human -DTXSID5033674 Css NA 0.003772 mg/L PBTK NA 50% Human Human -DTXSID5033674 Css NA 0.02729 mg/L PBTK NA 95% Human Human -DTXSID5033674 Clint NA 560.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033674 Fup NA 0.1834 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033674 Vd NA 1.037 L/kg 1compartment NA NA Rat Human +DTXSID5033674 TK.Half.Life NA 3.117 hours 1compartment NA NA Human Human +DTXSID5033674 Css NA 0.2146 mg/L 3compartmentss NA 50% Human Human +DTXSID5033674 Css NA 1.646 mg/L 3compartmentss NA 95% Human Human +DTXSID5033674 Css NA 0.1446 mg/L PBTK NA 50% Human Human +DTXSID5033674 Css NA 1.052 mg/L PBTK NA 95% Human Human +DTXSID5033674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033674 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033674 Vd NA 1.066 L/kg 1compartment NA NA Rat Human DTXSID5033674 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5033674 TK.Half.Life NA 0.3809 hours 1compartment NA NA Rat Human -DTXSID5033674 Css NA 0.003004 mg/L 3compartmentss NA 50% Rat Human -DTXSID5033674 Css NA 0.01796 mg/L 3compartmentss NA 95% Rat Human -DTXSID5033674 Css NA 0.002018 mg/L PBTK NA 50% Rat Human -DTXSID5033674 Css NA 0.01144 mg/L PBTK NA 95% Rat Human -DTXSID5033757 Clint NA 0.4752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033757 Fup NA 0.0423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033757 Vd NA 0.2799 L/kg 1compartment NA NA Human Human -DTXSID5033757 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5033757 TK.Half.Life NA 23.87 hours 1compartment NA NA Human Human -DTXSID5033757 Css NA 14.82 mg/L 3compartmentss NA 50% Human Human -DTXSID5033757 Css NA 86.32 mg/L 3compartmentss NA 95% Human Human -DTXSID5033757 Css NA 8.843 mg/L PBTK NA 50% Human Human -DTXSID5033757 Css NA 51.16 mg/L PBTK NA 95% Human Human -DTXSID5033757 Clint NA 0.4752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033757 Fup NA 0.0423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033757 Vd NA 0.2529 L/kg 1compartment NA NA Rat Human -DTXSID5033757 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5033757 TK.Half.Life NA 9.496 hours 1compartment NA NA Rat Human -DTXSID5033757 Css NA 5.565 mg/L 3compartmentss NA 50% Rat Human -DTXSID5033757 Css NA 26.85 mg/L 3compartmentss NA 95% Rat Human -DTXSID5033757 Css NA 3.088 mg/L PBTK NA 50% Rat Human -DTXSID5033757 Css NA 14.59 mg/L PBTK NA 95% Rat Human -DTXSID5033836 Clint NA 130.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033836 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5033836 Vd NA 3.112 L/kg 1compartment NA NA Human Human -DTXSID5033836 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5033836 TK.Half.Life NA 16.93 hours 1compartment NA NA Human Human -DTXSID5033836 Css NA 0.5736 mg/L 3compartmentss NA 50% Human Human -DTXSID5033836 Css NA 3.705 mg/L 3compartmentss NA 95% Human Human -DTXSID5033836 Css NA 0.398 mg/L PBTK NA 50% Human Human -DTXSID5033836 Css NA 2.485 mg/L PBTK NA 95% Human Human -DTXSID5033836 Clint NA 130.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033836 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5033836 Vd NA 2.33 L/kg 1compartment NA NA Rat Human -DTXSID5033836 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5033836 TK.Half.Life NA 2.719 hours 1compartment NA NA Rat Human -DTXSID5033836 Css NA 0.3254 mg/L 3compartmentss NA 50% Rat Human -DTXSID5033836 Css NA 1.545 mg/L 3compartmentss NA 95% Rat Human -DTXSID5033836 Css NA 0.216 mg/L PBTK NA 50% Rat Human -DTXSID5033836 Css NA 1.016 mg/L PBTK NA 95% Rat Human +DTXSID5033674 TK.Half.Life NA 1.252 hours 1compartment NA NA Rat Human +DTXSID5033674 Css NA 0.02782 mg/L 3compartmentss NA 50% Rat Human +DTXSID5033674 Css NA 0.1671 mg/L 3compartmentss NA 95% Rat Human +DTXSID5033674 Css NA 0.01839 mg/L PBTK NA 50% Rat Human +DTXSID5033674 Css NA 0.1036 mg/L PBTK NA 95% Rat Human +DTXSID5033757 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033757 Fup 0.0747 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033757 Vd NA 0.2931 L/kg 1compartment NA NA Human Human +DTXSID5033757 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5033757 TK.Half.Life NA 2.447 hours 1compartment NA NA Human Human +DTXSID5033757 Css NA 1.296 mg/L 3compartmentss NA 50% Human Human +DTXSID5033757 Css NA 8.755 mg/L 3compartmentss NA 95% Human Human +DTXSID5033757 Css NA 0.7896 mg/L PBTK NA 50% Human Human +DTXSID5033757 Css NA 5.07 mg/L PBTK NA 95% Human Human +DTXSID5033757 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033757 Fup 0.0747 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033757 Vd NA 0.2738 L/kg 1compartment NA NA Rat Human +DTXSID5033757 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5033757 TK.Half.Life NA 1.407 hours 1compartment NA NA Rat Human +DTXSID5033757 Css NA 0.1611 mg/L 3compartmentss NA 50% Rat Human +DTXSID5033757 Css NA 0.7806 mg/L 3compartmentss NA 95% Rat Human +DTXSID5033757 Css NA 0.0942 mg/L PBTK NA 50% Rat Human +DTXSID5033757 Css NA 0.4455 mg/L PBTK NA 95% Rat Human +DTXSID5033836 Clint 62.6 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID5033836 Fup 0.0166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5033836 Vd NA 3.108 L/kg 1compartment NA NA Human Human +DTXSID5033836 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5033836 TK.Half.Life NA 32.51 hours 1compartment NA NA Human Human +DTXSID5033836 Css NA 1.182 mg/L 3compartmentss NA 50% Human Human +DTXSID5033836 Css NA 7.502 mg/L 3compartmentss NA 95% Human Human +DTXSID5033836 Css NA 0.8162 mg/L PBTK NA 50% Human Human +DTXSID5033836 Css NA 5.051 mg/L PBTK NA 95% Human Human +DTXSID5033836 Clint 62.6 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human +DTXSID5033836 Fup 0.0166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5033836 Vd NA 2.329 L/kg 1compartment NA NA Rat Human +DTXSID5033836 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5033836 TK.Half.Life NA 3.072 hours 1compartment NA NA Rat Human +DTXSID5033836 Css NA 0.08676 mg/L 3compartmentss NA 50% Rat Human +DTXSID5033836 Css NA 0.4664 mg/L 3compartmentss NA 95% Rat Human +DTXSID5033836 Css NA 0.0597 mg/L PBTK NA 50% Rat Human +DTXSID5033836 Css NA 0.315 mg/L PBTK NA 95% Rat Human +DTXSID50338966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50338966 Fup 0.559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50338966 Vd NA 1.741 L/kg 1compartment NA NA Human Human +DTXSID50338966 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50338966 TK.Half.Life NA 1.706 hours 1compartment NA NA Human Human +DTXSID50338966 Css NA 0.03996 mg/L 3compartmentss NA 50% Human Human +DTXSID50338966 Css NA 0.4055 mg/L 3compartmentss NA 95% Human Human +DTXSID50338966 Css NA 0.03368 mg/L PBTK NA 50% Human Human +DTXSID50338966 Css NA 0.2926 mg/L PBTK NA 95% Human Human +DTXSID50338966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50338966 Fup 0.559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50338966 Vd NA 1.451 L/kg 1compartment NA NA Rat Human +DTXSID50338966 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50338966 TK.Half.Life NA 0.6627 hours 1compartment NA NA Rat Human +DTXSID50338966 Css NA 0.004936 mg/L 3compartmentss NA 50% Rat Human +DTXSID50338966 Css NA 0.04174 mg/L 3compartmentss NA 95% Rat Human +DTXSID50338966 Css NA 0.004261 mg/L PBTK NA 50% Rat Human +DTXSID50338966 Css NA 0.0292 mg/L PBTK NA 95% Rat Human +DTXSID5034141 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034141 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034141 Vd NA 2.617 L/kg 1compartment NA NA Human Human +DTXSID5034141 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5034141 TK.Half.Life NA 11.03 hours 1compartment NA NA Human Human +DTXSID5034141 Css NA 0.4521 mg/L 3compartmentss NA 50% Human Human +DTXSID5034141 Css NA 2.938 mg/L 3compartmentss NA 95% Human Human +DTXSID5034141 Css NA 0.315 mg/L PBTK NA 50% Human Human +DTXSID5034141 Css NA 1.957 mg/L PBTK NA 95% Human Human +DTXSID5034141 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034141 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034141 Vd NA 1.976 L/kg 1compartment NA NA Rat Human +DTXSID5034141 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5034141 TK.Half.Life NA 2.732 hours 1compartment NA NA Rat Human +DTXSID5034141 Css NA 0.05842 mg/L 3compartmentss NA 50% Rat Human +DTXSID5034141 Css NA 0.2968 mg/L 3compartmentss NA 95% Rat Human +DTXSID5034141 Css NA 0.04007 mg/L PBTK NA 50% Rat Human +DTXSID5034141 Css NA 0.195 mg/L PBTK NA 95% Rat Human DTXSID5034270 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5034270 Fup 0.5468 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID5034270 Vd NA 2.314 L/kg 1compartment NA NA Human Human +DTXSID5034270 Vd NA 2.327 L/kg 1compartment NA NA Human Human DTXSID5034270 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID5034270 TK.Half.Life NA 54.84 hours 1compartment NA NA Human Human -DTXSID5034270 Css NA 2.481 mg/L 3compartmentss NA 50% Human Human -DTXSID5034270 Css NA 10.96 mg/L 3compartmentss NA 95% Human Human -DTXSID5034270 Css NA 2.061 mg/L PBTK NA 50% Human Human -DTXSID5034270 Css NA 7.359 mg/L PBTK NA 95% Human Human +DTXSID5034270 TK.Half.Life NA 55.81 hours 1compartment NA NA Human Human +DTXSID5034270 Css NA 1.828 mg/L 3compartmentss NA 50% Human Human +DTXSID5034270 Css NA 8.4 mg/L 3compartmentss NA 95% Human Human +DTXSID5034270 Css NA 1.507 mg/L PBTK NA 50% Human Human +DTXSID5034270 Css NA 5.666 mg/L PBTK NA 95% Human Human DTXSID5034270 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID5034270 Fup 0.5468 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID5034270 Vd NA 1.836 L/kg 1compartment NA NA Rat Human +DTXSID5034270 Vd NA 1.844 L/kg 1compartment NA NA Rat Human DTXSID5034270 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5034270 TK.Half.Life NA 9.176 hours 1compartment NA NA Rat Human -DTXSID5034270 Css NA 0.6574 mg/L 3compartmentss NA 50% Rat Human -DTXSID5034270 Css NA 2.561 mg/L 3compartmentss NA 95% Rat Human -DTXSID5034270 Css NA 0.5272 mg/L PBTK NA 50% Rat Human -DTXSID5034270 Css NA 1.603 mg/L PBTK NA 95% Rat Human +DTXSID5034270 TK.Half.Life NA 9.256 hours 1compartment NA NA Rat Human +DTXSID5034270 Css NA 0.01566 mg/L 3compartmentss NA 50% Rat Human +DTXSID5034270 Css NA 0.1178 mg/L 3compartmentss NA 95% Rat Human +DTXSID5034270 Css NA 0.0125 mg/L PBTK NA 50% Rat Human +DTXSID5034270 Css NA 0.08436 mg/L PBTK NA 95% Rat Human DTXSID5034303 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID5034303 Fup NA 0.025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034303 Vd NA 2.854 L/kg 1compartment NA NA Human Human -DTXSID5034303 Days.Css NA 1419 Days PBTK NA NA Human Human -DTXSID5034303 TK.Half.Life NA 5255 hours 1compartment NA NA Human Human -DTXSID5034303 Css NA 232.5 mg/L 3compartmentss NA 50% Human Human -DTXSID5034303 Css NA 721.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5034303 Css NA 157.9 mg/L PBTK NA 50% Human Human -DTXSID5034303 Css NA 452.7 mg/L PBTK NA 95% Human Human +DTXSID5034303 Fup 0.0127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034303 Vd NA 2.623 L/kg 1compartment NA NA Human Human +DTXSID5034303 Days.Css NA 1490 Days PBTK NA NA Human Human +DTXSID5034303 TK.Half.Life NA 5488 hours 1compartment NA NA Human Human +DTXSID5034303 Css NA 271.9 mg/L 3compartmentss NA 50% Human Human +DTXSID5034303 Css NA 956.8 mg/L 3compartmentss NA 95% Human Human +DTXSID5034303 Css NA 181 mg/L PBTK NA 50% Human Human +DTXSID5034303 Css NA 592.6 mg/L PBTK NA 95% Human Human DTXSID5034303 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID5034303 Fup NA 0.025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034303 Vd NA 2.136 L/kg 1compartment NA NA Rat Human -DTXSID5034303 Days.Css NA 357 Days PBTK NA NA Rat Human -DTXSID5034303 TK.Half.Life NA 463 hours 1compartment NA NA Rat Human -DTXSID5034303 Css NA 63.23 mg/L 3compartmentss NA 50% Rat Human -DTXSID5034303 Css NA 161.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID5034303 Css NA 40.99 mg/L PBTK NA 50% Rat Human -DTXSID5034303 Css NA 94.67 mg/L PBTK NA 95% Rat Human -DTXSID5034355 Clint NA 5.152 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034355 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034355 Vd NA 2.837 L/kg 1compartment NA NA Human Human -DTXSID5034355 Days.Css NA 50 Days PBTK NA NA Human Human -DTXSID5034355 TK.Half.Life NA 240.3 hours 1compartment NA NA Human Human -DTXSID5034355 Css NA 11.88 mg/L 3compartmentss NA 50% Human Human -DTXSID5034355 Css NA 75.35 mg/L 3compartmentss NA 95% Human Human -DTXSID5034355 Css NA 8.031 mg/L PBTK NA 50% Human Human -DTXSID5034355 Css NA 49.43 mg/L PBTK NA 95% Human Human -DTXSID5034355 Clint NA 5.152 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034355 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034355 Vd NA 2.12 L/kg 1compartment NA NA Rat Human -DTXSID5034355 Days.Css NA 27 Days PBTK NA NA Rat Human -DTXSID5034355 TK.Half.Life NA 43.38 hours 1compartment NA NA Rat Human -DTXSID5034355 Css NA 6.538 mg/L 3compartmentss NA 50% Rat Human -DTXSID5034355 Css NA 32.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID5034355 Css NA 4.201 mg/L PBTK NA 50% Rat Human -DTXSID5034355 Css NA 20.02 mg/L PBTK NA 95% Rat Human -DTXSID5034357 Clint NA 46.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034357 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034357 Vd NA 2.723 L/kg 1compartment NA NA Human Human -DTXSID5034357 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5034357 TK.Half.Life NA 33.44 hours 1compartment NA NA Human Human -DTXSID5034357 Css NA 1.708 mg/L 3compartmentss NA 50% Human Human -DTXSID5034357 Css NA 10.94 mg/L 3compartmentss NA 95% Human Human -DTXSID5034357 Css NA 1.142 mg/L PBTK NA 50% Human Human -DTXSID5034357 Css NA 7.078 mg/L PBTK NA 95% Human Human -DTXSID5034357 Clint NA 46.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034357 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034357 Vd NA 2.031 L/kg 1compartment NA NA Rat Human -DTXSID5034357 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5034357 TK.Half.Life NA 6.98 hours 1compartment NA NA Rat Human -DTXSID5034357 Css NA 0.9452 mg/L 3compartmentss NA 50% Rat Human -DTXSID5034357 Css NA 5.645 mg/L 3compartmentss NA 95% Rat Human -DTXSID5034357 Css NA 0.599 mg/L PBTK NA 50% Rat Human -DTXSID5034357 Css NA 3.387 mg/L PBTK NA 95% Rat Human -DTXSID5034698 Clint NA 5.085 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034698 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034698 Vd NA 3.111 L/kg 1compartment NA NA Human Human -DTXSID5034698 Days.Css NA 86 Days PBTK NA NA Human Human -DTXSID5034698 TK.Half.Life NA 382.1 hours 1compartment NA NA Human Human -DTXSID5034698 Css NA 15.04 mg/L 3compartmentss NA 50% Human Human -DTXSID5034698 Css NA 89.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5034698 Css NA 10.42 mg/L PBTK NA 50% Human Human -DTXSID5034698 Css NA 61.84 mg/L PBTK NA 95% Human Human -DTXSID5034698 Clint NA 5.085 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034698 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034698 Vd NA 2.33 L/kg 1compartment NA NA Rat Human -DTXSID5034698 Days.Css NA 47 Days PBTK NA NA Rat Human -DTXSID5034698 TK.Half.Life NA 50.26 hours 1compartment NA NA Rat Human -DTXSID5034698 Css NA 8.584 mg/L 3compartmentss NA 50% Rat Human -DTXSID5034698 Css NA 37.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID5034698 Css NA 5.691 mg/L PBTK NA 50% Rat Human -DTXSID5034698 Css NA 24.09 mg/L PBTK NA 95% Rat Human +DTXSID5034303 Fup 0.0127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034303 Vd NA 1.957 L/kg 1compartment NA NA Rat Human +DTXSID5034303 Days.Css NA 376 Days PBTK NA NA Rat Human +DTXSID5034303 TK.Half.Life NA 591.4 hours 1compartment NA NA Rat Human +DTXSID5034303 Css NA 17.26 mg/L 3compartmentss NA 50% Rat Human +DTXSID5034303 Css NA 48.91 mg/L 3compartmentss NA 95% Rat Human +DTXSID5034303 Css NA 11.29 mg/L PBTK NA 50% Rat Human +DTXSID5034303 Css NA 29.16 mg/L PBTK NA 95% Rat Human +DTXSID5034355 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034355 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034355 Vd NA 2.953 L/kg 1compartment NA NA Human Human +DTXSID5034355 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID5034355 TK.Half.Life NA 58.59 hours 1compartment NA NA Human Human +DTXSID5034355 Css NA 2.499 mg/L 3compartmentss NA 50% Human Human +DTXSID5034355 Css NA 17.08 mg/L 3compartmentss NA 95% Human Human +DTXSID5034355 Css NA 1.704 mg/L PBTK NA 50% Human Human +DTXSID5034355 Css NA 11.17 mg/L PBTK NA 95% Human Human +DTXSID5034355 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034355 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034355 Vd NA 2.21 L/kg 1compartment NA NA Rat Human +DTXSID5034355 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID5034355 TK.Half.Life NA 9.819 hours 1compartment NA NA Rat Human +DTXSID5034355 Css NA 0.3228 mg/L 3compartmentss NA 50% Rat Human +DTXSID5034355 Css NA 1.938 mg/L 3compartmentss NA 95% Rat Human +DTXSID5034355 Css NA 0.2181 mg/L PBTK NA 50% Rat Human +DTXSID5034355 Css NA 1.271 mg/L PBTK NA 95% Rat Human +DTXSID5034357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034357 Fup 0.00767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034357 Vd NA 2.887 L/kg 1compartment NA NA Human Human +DTXSID5034357 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID5034357 TK.Half.Life NA 68.02 hours 1compartment NA NA Human Human +DTXSID5034357 Css NA 3.066 mg/L 3compartmentss NA 50% Human Human +DTXSID5034357 Css NA 21.62 mg/L 3compartmentss NA 95% Human Human +DTXSID5034357 Css NA 2.078 mg/L PBTK NA 50% Human Human +DTXSID5034357 Css NA 14 mg/L PBTK NA 95% Human Human +DTXSID5034357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034357 Fup 0.00767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034357 Vd NA 2.158 L/kg 1compartment NA NA Rat Human +DTXSID5034357 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID5034357 TK.Half.Life NA 12 hours 1compartment NA NA Rat Human +DTXSID5034357 Css NA 0.4036 mg/L 3compartmentss NA 50% Rat Human +DTXSID5034357 Css NA 2.435 mg/L 3compartmentss NA 95% Rat Human +DTXSID5034357 Css NA 0.2704 mg/L PBTK NA 50% Rat Human +DTXSID5034357 Css NA 1.6 mg/L PBTK NA 95% Rat Human +DTXSID5034698 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034698 Fup 0.0141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034698 Vd NA 3.106 L/kg 1compartment NA NA Human Human +DTXSID5034698 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID5034698 TK.Half.Life NA 89.82 hours 1compartment NA NA Human Human +DTXSID5034698 Css NA 3.417 mg/L 3compartmentss NA 50% Human Human +DTXSID5034698 Css NA 21.88 mg/L 3compartmentss NA 95% Human Human +DTXSID5034698 Css NA 2.383 mg/L PBTK NA 50% Human Human +DTXSID5034698 Css NA 14.72 mg/L PBTK NA 95% Human Human +DTXSID5034698 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034698 Fup 0.0141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034698 Vd NA 2.326 L/kg 1compartment NA NA Rat Human +DTXSID5034698 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID5034698 TK.Half.Life NA 12.3 hours 1compartment NA NA Rat Human +DTXSID5034698 Css NA 0.4483 mg/L 3compartmentss NA 50% Rat Human +DTXSID5034698 Css NA 2.279 mg/L 3compartmentss NA 95% Rat Human +DTXSID5034698 Css NA 0.3076 mg/L PBTK NA 50% Rat Human +DTXSID5034698 Css NA 1.571 mg/L PBTK NA 95% Rat Human DTXSID5034723 Clint 20.42 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5034723 Fup 0.01655 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5034723 Vd NA 0.1937 L/kg 1compartment NA NA Human Human DTXSID5034723 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5034723 TK.Half.Life NA 2.322 hours 1compartment NA NA Human Human -DTXSID5034723 Css NA 1.854 mg/L 3compartmentss NA 50% Human Human -DTXSID5034723 Css NA 19.49 mg/L 3compartmentss NA 95% Human Human -DTXSID5034723 Css NA 1.295 mg/L PBTK NA 50% Human Human -DTXSID5034723 Css NA 12.22 mg/L PBTK NA 95% Human Human +DTXSID5034723 Css NA 1.466 mg/L 3compartmentss NA 50% Human Human +DTXSID5034723 Css NA 14.6 mg/L 3compartmentss NA 95% Human Human +DTXSID5034723 Css NA 1.024 mg/L PBTK NA 50% Human Human +DTXSID5034723 Css NA 10.2 mg/L PBTK NA 95% Human Human DTXSID5034723 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5034723 Fup 0.06219 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5034723 Vd NA 0.2643 L/kg 1compartment NA NA Rat Rat DTXSID5034723 Days.Css NA 1 Days PBTK NA NA Rat Rat DTXSID5034723 TK.Half.Life NA 9.371 hours 1compartment NA NA Rat Rat -DTXSID5034723 Css NA 4.231 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5034723 Css NA 17.66 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5034723 Css NA 2.758 mg/L PBTK NA 50% Rat Rat -DTXSID5034723 Css NA 10.08 mg/L PBTK NA 95% Rat Rat -DTXSID5034729 Clint NA 42.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034729 Fup NA 0.0715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034729 Vd NA 0.8577 L/kg 1compartment NA NA Human Human +DTXSID5034723 Css NA 0.1522 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5034723 Css NA 1.079 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5034723 Css NA 0.107 mg/L PBTK NA 50% Rat Rat +DTXSID5034723 Css NA 0.7677 mg/L PBTK NA 95% Rat Rat +DTXSID50347235 Clint 32.36 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50347235 Fup 0.0204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50347235 Vd NA 1.646 L/kg 1compartment NA NA Human Human +DTXSID50347235 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50347235 TK.Half.Life NA 10.8 hours 1compartment NA NA Human Human +DTXSID50347235 Css NA 0.9686 mg/L 3compartmentss NA 50% Human Human +DTXSID50347235 Css NA 8.378 mg/L 3compartmentss NA 95% Human Human +DTXSID50347235 Css NA 0.6083 mg/L PBTK NA 50% Human Human +DTXSID50347235 Css NA 5.143 mg/L PBTK NA 95% Human Human +DTXSID50347235 Clint 32.36 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50347235 Fup 0.0204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50347235 Vd NA 1.222 L/kg 1compartment NA NA Rat Human +DTXSID50347235 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50347235 TK.Half.Life NA 3.972 hours 1compartment NA NA Rat Human +DTXSID50347235 Css NA 0.1243 mg/L 3compartmentss NA 50% Rat Human +DTXSID50347235 Css NA 0.9206 mg/L 3compartmentss NA 95% Rat Human +DTXSID50347235 Css NA 0.07644 mg/L PBTK NA 50% Rat Human +DTXSID50347235 Css NA 0.5467 mg/L PBTK NA 95% Rat Human +DTXSID5034729 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034729 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034729 Vd NA 0.531 L/kg 1compartment NA NA Human Human DTXSID5034729 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5034729 TK.Half.Life NA 1.831 hours 1compartment NA NA Human Human -DTXSID5034729 Css NA 0.2074 mg/L 3compartmentss NA 50% Human Human -DTXSID5034729 Css NA 1.624 mg/L 3compartmentss NA 95% Human Human -DTXSID5034729 Css NA 0.131 mg/L PBTK NA 50% Human Human -DTXSID5034729 Css NA 0.969 mg/L PBTK NA 95% Human Human -DTXSID5034729 Clint NA 42.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034729 Fup NA 0.0715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034729 Vd NA 0.6729 L/kg 1compartment NA NA Rat Human +DTXSID5034729 TK.Half.Life NA 1.218 hours 1compartment NA NA Human Human +DTXSID5034729 Css NA 0.23 mg/L 3compartmentss NA 50% Human Human +DTXSID5034729 Css NA 1.886 mg/L 3compartmentss NA 95% Human Human +DTXSID5034729 Css NA 0.1473 mg/L PBTK NA 50% Human Human +DTXSID5034729 Css NA 1.146 mg/L PBTK NA 95% Human Human +DTXSID5034729 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034729 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5034729 Vd NA 0.4555 L/kg 1compartment NA NA Rat Human DTXSID5034729 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5034729 TK.Half.Life NA 0.7959 hours 1compartment NA NA Rat Human -DTXSID5034729 Css NA 0.1191 mg/L 3compartmentss NA 50% Rat Human -DTXSID5034729 Css NA 0.6436 mg/L 3compartmentss NA 95% Rat Human -DTXSID5034729 Css NA 0.07036 mg/L PBTK NA 50% Rat Human -DTXSID5034729 Css NA 0.3709 mg/L PBTK NA 95% Rat Human +DTXSID5034729 TK.Half.Life NA 0.6033 hours 1compartment NA NA Rat Human +DTXSID5034729 Css NA 0.02984 mg/L 3compartmentss NA 50% Rat Human +DTXSID5034729 Css NA 0.1911 mg/L 3compartmentss NA 95% Rat Human +DTXSID5034729 Css NA 0.01865 mg/L PBTK NA 50% Rat Human +DTXSID5034729 Css NA 0.1132 mg/L PBTK NA 95% Rat Human DTXSID5034773 Clint 2.873 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID5034773 Fup NA 0.0056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034773 Vd NA 2.894 L/kg 1compartment NA NA Human Human -DTXSID5034773 Days.Css NA 128 Days PBTK NA NA Human Human -DTXSID5034773 TK.Half.Life NA 540.7 hours 1compartment NA NA Human Human -DTXSID5034773 Css NA 29.52 mg/L 3compartmentss NA 50% Human Human -DTXSID5034773 Css NA 182.2 mg/L 3compartmentss NA 95% Human Human -DTXSID5034773 Css NA 17.36 mg/L PBTK NA 50% Human Human -DTXSID5034773 Css NA 106.3 mg/L PBTK NA 95% Human Human +DTXSID5034773 Fup 0.00771 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5034773 Vd NA 2.957 L/kg 1compartment NA NA Human Human +DTXSID5034773 Days.Css NA 126 Days PBTK NA NA Human Human +DTXSID5034773 TK.Half.Life NA 535.2 hours 1compartment NA NA Human Human +DTXSID5034773 Css NA 24.94 mg/L 3compartmentss NA 50% Human Human +DTXSID5034773 Css NA 152.3 mg/L 3compartmentss NA 95% Human Human +DTXSID5034773 Css NA 16.05 mg/L PBTK NA 50% Human Human +DTXSID5034773 Css NA 98.06 mg/L PBTK NA 95% Human Human DTXSID5034773 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5034773 Fup 0.01396 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID5034773 Vd NA 2.273 L/kg 1compartment NA NA Rat Rat -DTXSID5034773 Days.Css NA 1973 Days PBTK NA NA Rat Rat -DTXSID5034773 TK.Half.Life NA 1982 hours 1compartment NA NA Rat Rat -DTXSID5034773 Css NA 363 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5034773 Css NA 760.1 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5034773 Css NA 197.5 mg/L PBTK NA 50% Rat Rat -DTXSID5034773 Css NA 412 mg/L PBTK NA 95% Rat Rat -DTXSID5034981 Clint NA 88.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034981 Fup NA 0.0049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5034981 Vd NA 55.62 L/kg 1compartment NA NA Human Human -DTXSID5034981 Days.Css NA 88 Days PBTK NA NA Human Human -DTXSID5034981 TK.Half.Life NA 413.3 hours 1compartment NA NA Human Human -DTXSID5034981 Css NA 0.1003 mg/L 3compartmentss NA 50% Human Human -DTXSID5034981 Css NA 0.584 mg/L 3compartmentss NA 95% Human Human -DTXSID5034981 Css NA 0.6175 mg/L PBTK NA 50% Human Human -DTXSID5034981 Css NA 3.318 mg/L PBTK NA 95% Human Human -DTXSID5034981 Clint NA 88.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034981 Fup NA 0.0049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5034981 Vd NA 47.08 L/kg 1compartment NA NA Rat Human -DTXSID5034981 Days.Css NA 58 Days PBTK NA NA Rat Human -DTXSID5034981 TK.Half.Life NA 64.66 hours 1compartment NA NA Rat Human -DTXSID5034981 Css NA 0.05124 mg/L 3compartmentss NA 50% Rat Human -DTXSID5034981 Css NA 0.2166 mg/L 3compartmentss NA 95% Rat Human -DTXSID5034981 Css NA 0.3342 mg/L PBTK NA 50% Rat Human -DTXSID5034981 Css NA 1.444 mg/L PBTK NA 95% Rat Human +DTXSID5034773 Vd 2.3 2.273 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID5034773 Days.Css NA 1975 Days PBTK NA NA Rat Rat +DTXSID5034773 TK.Half.Life 0.96 1982 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID5034773 Css 0.025 68.93 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID5034773 Css 0.025 141.1 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID5034773 Css 0.025 45.94 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID5034773 Css 0.025 94.04 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID5035080 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5035080 Fup 0.048 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5035080 Vd NA 3.128 L/kg 1compartment NA NA Human Human +DTXSID5035080 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID5035080 TK.Half.Life NA 87.56 hours 1compartment NA NA Human Human +DTXSID5035080 Css NA 2.955 mg/L 3compartmentss NA 50% Human Human +DTXSID5035080 Css NA 19.75 mg/L 3compartmentss NA 95% Human Human +DTXSID5035080 Css NA 2.054 mg/L PBTK NA 50% Human Human +DTXSID5035080 Css NA 13.31 mg/L PBTK NA 95% Human Human DTXSID5035080 Clint 8556 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID5035080 Fup 0.035 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID5035080 Vd NA 1.269 L/kg 1compartment NA NA Rat Rat +DTXSID5035080 Vd NA 2.34 L/kg 1compartment NA NA Rat Rat DTXSID5035080 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID5035080 TK.Half.Life NA 0.5271 hours 1compartment NA NA Rat Rat -DTXSID5035080 Css NA 0.001411 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5035080 Css NA 0.009156 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5035080 Css NA 0.0008466 mg/L PBTK NA 50% Rat Rat -DTXSID5035080 Css NA 0.005368 mg/L PBTK NA 95% Rat Rat -DTXSID5035163 Clint NA 999.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5035163 Fup NA 0.4279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5035163 Vd NA 1.583 L/kg 1compartment NA NA Human Human +DTXSID5035080 TK.Half.Life NA 0.962 hours 1compartment NA NA Rat Rat +DTXSID5035080 Css NA 0.0002507 mg/L 3compartmentss NA 50% Rat Rat +DTXSID5035080 Css NA 0.00235 mg/L 3compartmentss NA 95% Rat Rat +DTXSID5035080 Css NA 0.0001703 mg/L PBTK NA 50% Rat Rat +DTXSID5035080 Css NA 0.001536 mg/L PBTK NA 95% Rat Rat +DTXSID5035163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5035163 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5035163 Vd NA 1.345 L/kg 1compartment NA NA Human Human DTXSID5035163 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5035163 TK.Half.Life NA 1.07 hours 1compartment NA NA Human Human -DTXSID5035163 Css NA 0.001238 mg/L 3compartmentss NA 50% Human Human -DTXSID5035163 Css NA 0.01015 mg/L 3compartmentss NA 95% Human Human -DTXSID5035163 Css NA 0.0009926 mg/L PBTK NA 50% Human Human -DTXSID5035163 Css NA 0.007264 mg/L PBTK NA 95% Human Human -DTXSID5035163 Clint NA 999.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5035163 Fup NA 0.4279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5035163 Vd NA 1.307 L/kg 1compartment NA NA Rat Human +DTXSID5035163 TK.Half.Life NA 1.698 hours 1compartment NA NA Human Human +DTXSID5035163 Css NA 0.0641 mg/L 3compartmentss NA 50% Human Human +DTXSID5035163 Css NA 0.4846 mg/L 3compartmentss NA 95% Human Human +DTXSID5035163 Css NA 0.04929 mg/L PBTK NA 50% Human Human +DTXSID5035163 Css NA 0.3364 mg/L PBTK NA 95% Human Human +DTXSID5035163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5035163 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5035163 Vd NA 1.114 L/kg 1compartment NA NA Rat Human DTXSID5035163 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5035163 TK.Half.Life NA 0.3821 hours 1compartment NA NA Rat Human -DTXSID5035163 Css NA 0.0006712 mg/L 3compartmentss NA 50% Rat Human -DTXSID5035163 Css NA 0.004493 mg/L 3compartmentss NA 95% Rat Human -DTXSID5035163 Css NA 0.0005238 mg/L PBTK NA 50% Rat Human -DTXSID5035163 Css NA 0.003118 mg/L PBTK NA 95% Rat Human -DTXSID5035589 Clint NA 630 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5035589 Fup NA 0.222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5035589 Vd NA 3.141 L/kg 1compartment NA NA Human Human -DTXSID5035589 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5035589 TK.Half.Life NA 5.093 hours 1compartment NA NA Human Human -DTXSID5035589 Css NA 0.09997 mg/L 3compartmentss NA 50% Human Human -DTXSID5035589 Css NA 0.625 mg/L 3compartmentss NA 95% Human Human -DTXSID5035589 Css NA 0.06968 mg/L PBTK NA 50% Human Human -DTXSID5035589 Css NA 0.4285 mg/L PBTK NA 95% Human Human -DTXSID5035589 Clint NA 630 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5035589 Fup NA 0.222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5035589 Vd NA 2.357 L/kg 1compartment NA NA Rat Human -DTXSID5035589 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5035589 TK.Half.Life NA 1.164 hours 1compartment NA NA Rat Human -DTXSID5035589 Css NA 0.05562 mg/L 3compartmentss NA 50% Rat Human -DTXSID5035589 Css NA 0.307 mg/L 3compartmentss NA 95% Rat Human -DTXSID5035589 Css NA 0.037 mg/L PBTK NA 50% Rat Human -DTXSID5035589 Css NA 0.1989 mg/L PBTK NA 95% Rat Human -DTXSID5035616 Clint NA 0.01956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5035616 Fup NA 0.23 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5035616 Vd NA 0.6138 L/kg 1compartment NA NA Human Human -DTXSID5035616 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5035616 TK.Half.Life NA 17.23 hours 1compartment NA NA Human Human -DTXSID5035616 Css NA 3.336 mg/L 3compartmentss NA 50% Human Human -DTXSID5035616 Css NA 12.55 mg/L 3compartmentss NA 95% Human Human -DTXSID5035616 Css NA 2.279 mg/L PBTK NA 50% Human Human -DTXSID5035616 Css NA 7.871 mg/L PBTK NA 95% Human Human -DTXSID5035616 Clint NA 0.01956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5035616 Fup NA 0.23 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5035616 Vd NA 0.5395 L/kg 1compartment NA NA Rat Human +DTXSID5035163 TK.Half.Life NA 0.6994 hours 1compartment NA NA Rat Human +DTXSID5035163 Css NA 0.007927 mg/L 3compartmentss NA 50% Rat Human +DTXSID5035163 Css NA 0.04474 mg/L 3compartmentss NA 95% Rat Human +DTXSID5035163 Css NA 0.006128 mg/L PBTK NA 50% Rat Human +DTXSID5035163 Css NA 0.03086 mg/L PBTK NA 95% Rat Human +DTXSID5035616 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5035616 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5035616 Vd NA 0.7081 L/kg 1compartment NA NA Human Human +DTXSID5035616 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5035616 TK.Half.Life NA 1.224 hours 1compartment NA NA Human Human +DTXSID5035616 Css NA 0.1165 mg/L 3compartmentss NA 50% Human Human +DTXSID5035616 Css NA 0.8072 mg/L 3compartmentss NA 95% Human Human +DTXSID5035616 Css NA 0.07796 mg/L PBTK NA 50% Human Human +DTXSID5035616 Css NA 0.5229 mg/L PBTK NA 95% Human Human +DTXSID5035616 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5035616 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5035616 Vd NA 0.5951 L/kg 1compartment NA NA Rat Human DTXSID5035616 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5035616 TK.Half.Life NA 5.127 hours 1compartment NA NA Rat Human -DTXSID5035616 Css NA 0.9502 mg/L 3compartmentss NA 50% Rat Human -DTXSID5035616 Css NA 3.019 mg/L 3compartmentss NA 95% Rat Human -DTXSID5035616 Css NA 0.6138 mg/L PBTK NA 50% Rat Human -DTXSID5035616 Css NA 1.741 mg/L PBTK NA 95% Rat Human +DTXSID5035616 TK.Half.Life NA 0.5613 hours 1compartment NA NA Rat Human +DTXSID5035616 Css NA 0.01497 mg/L 3compartmentss NA 50% Rat Human +DTXSID5035616 Css NA 0.07777 mg/L 3compartmentss NA 95% Rat Human +DTXSID5035616 Css NA 0.009915 mg/L PBTK NA 50% Rat Human +DTXSID5035616 Css NA 0.04915 mg/L PBTK NA 95% Rat Human DTXSID5035957 Clint 23.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5035957 Fup 1.82e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5035957 Vd NA 2.365 L/kg 1compartment NA NA Human Human DTXSID5035957 Days.Css NA 17 Days PBTK NA NA Human Human DTXSID5035957 TK.Half.Life NA 97.75 hours 1compartment NA NA Human Human -DTXSID5035957 Css NA 4.527 mg/L 3compartmentss NA 50% Human Human -DTXSID5035957 Css NA 29.48 mg/L 3compartmentss NA 95% Human Human -DTXSID5035957 Css NA 3.01 mg/L PBTK NA 50% Human Human -DTXSID5035957 Css NA 19.55 mg/L PBTK NA 95% Human Human +DTXSID5035957 Css NA 4.469 mg/L 3compartmentss NA 50% Human Human +DTXSID5035957 Css NA 30.06 mg/L 3compartmentss NA 95% Human Human +DTXSID5035957 Css NA 2.967 mg/L PBTK NA 50% Human Human +DTXSID5035957 Css NA 19.81 mg/L PBTK NA 95% Human Human DTXSID5035957 Clint 23.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5035957 Fup 1.82e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5035957 Vd NA 1.753 L/kg 1compartment NA NA Rat Human DTXSID5035957 Days.Css NA 9 Days PBTK NA NA Rat Human DTXSID5035957 TK.Half.Life NA 50.45 hours 1compartment NA NA Rat Human -DTXSID5035957 Css NA 2.663 mg/L 3compartmentss NA 50% Rat Human -DTXSID5035957 Css NA 13.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID5035957 Css NA 1.685 mg/L PBTK NA 50% Rat Human -DTXSID5035957 Css NA 8.293 mg/L PBTK NA 95% Rat Human -DTXSID5036684 Clint NA 18.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5036684 Fup NA 0.0612 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5036684 Vd NA 1.543 L/kg 1compartment NA NA Human Human +DTXSID5035957 Css NA 0.5994 mg/L 3compartmentss NA 50% Rat Human +DTXSID5035957 Css NA 3.134 mg/L 3compartmentss NA 95% Rat Human +DTXSID5035957 Css NA 0.3914 mg/L PBTK NA 50% Rat Human +DTXSID5035957 Css NA 2.054 mg/L PBTK NA 95% Rat Human +DTXSID5036684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5036684 Fup 0.0295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5036684 Vd NA 1.099 L/kg 1compartment NA NA Human Human DTXSID5036684 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5036684 TK.Half.Life NA 7.135 hours 1compartment NA NA Human Human -DTXSID5036684 Css NA 0.6284 mg/L 3compartmentss NA 50% Human Human -DTXSID5036684 Css NA 4.407 mg/L 3compartmentss NA 95% Human Human -DTXSID5036684 Css NA 0.406 mg/L PBTK NA 50% Human Human -DTXSID5036684 Css NA 2.741 mg/L PBTK NA 95% Human Human -DTXSID5036684 Clint NA 18.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5036684 Fup NA 0.0612 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5036684 Vd NA 1.163 L/kg 1compartment NA NA Rat Human +DTXSID5036684 TK.Half.Life NA 7.227 hours 1compartment NA NA Human Human +DTXSID5036684 Css NA 1.004 mg/L 3compartmentss NA 50% Human Human +DTXSID5036684 Css NA 9.212 mg/L 3compartmentss NA 95% Human Human +DTXSID5036684 Css NA 0.6208 mg/L PBTK NA 50% Human Human +DTXSID5036684 Css NA 5.511 mg/L PBTK NA 95% Human Human +DTXSID5036684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5036684 Fup 0.0295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5036684 Vd NA 0.8222 L/kg 1compartment NA NA Rat Human DTXSID5036684 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5036684 TK.Half.Life NA 2.719 hours 1compartment NA NA Rat Human -DTXSID5036684 Css NA 0.351 mg/L 3compartmentss NA 50% Rat Human -DTXSID5036684 Css NA 1.919 mg/L 3compartmentss NA 95% Rat Human -DTXSID5036684 Css NA 0.2137 mg/L PBTK NA 50% Rat Human -DTXSID5036684 Css NA 1.123 mg/L PBTK NA 95% Rat Human -DTXSID5037028 Clint NA 69.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037028 Fup NA 0.4073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037028 Vd NA 4.105 L/kg 1compartment NA NA Human Human -DTXSID5037028 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5037028 TK.Half.Life NA 3.529 hours 1compartment NA NA Human Human -DTXSID5037028 Css NA 0.02305 mg/L 3compartmentss NA 50% Human Human -DTXSID5037028 Css NA 0.1503 mg/L 3compartmentss NA 95% Human Human -DTXSID5037028 Css NA 0.02059 mg/L PBTK NA 50% Human Human -DTXSID5037028 Css NA 0.1247 mg/L PBTK NA 95% Human Human -DTXSID5037028 Clint NA 69.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037028 Fup NA 0.4073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037028 Vd NA 3.455 L/kg 1compartment NA NA Rat Human -DTXSID5037028 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5037028 TK.Half.Life NA 1.093 hours 1compartment NA NA Rat Human -DTXSID5037028 Css NA 0.01269 mg/L 3compartmentss NA 50% Rat Human -DTXSID5037028 Css NA 0.06891 mg/L 3compartmentss NA 95% Rat Human -DTXSID5037028 Css NA 0.01114 mg/L PBTK NA 50% Rat Human -DTXSID5037028 Css NA 0.05768 mg/L PBTK NA 95% Rat Human -DTXSID5037072 Clint NA 0.09923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037072 Fup NA 0.215 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037072 Vd NA 0.494 L/kg 1compartment NA NA Human Human -DTXSID5037072 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5037072 TK.Half.Life NA 12.85 hours 1compartment NA NA Human Human -DTXSID5037072 Css NA 2.974 mg/L 3compartmentss NA 50% Human Human -DTXSID5037072 Css NA 11.19 mg/L 3compartmentss NA 95% Human Human -DTXSID5037072 Css NA 2.086 mg/L PBTK NA 50% Human Human -DTXSID5037072 Css NA 6.961 mg/L PBTK NA 95% Human Human -DTXSID5037072 Clint NA 0.09923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037072 Fup NA 0.215 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037072 Vd NA 0.4723 L/kg 1compartment NA NA Rat Human +DTXSID5036684 TK.Half.Life NA 3.092 hours 1compartment NA NA Rat Human +DTXSID5036684 Css NA 0.1312 mg/L 3compartmentss NA 50% Rat Human +DTXSID5036684 Css NA 0.9485 mg/L 3compartmentss NA 95% Rat Human +DTXSID5036684 Css NA 0.0785 mg/L PBTK NA 50% Rat Human +DTXSID5036684 Css NA 0.5472 mg/L PBTK NA 95% Rat Human +DTXSID5037072 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037072 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037072 Vd NA 0.47 L/kg 1compartment NA NA Human Human +DTXSID5037072 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5037072 TK.Half.Life NA 7.061 hours 1compartment NA NA Human Human +DTXSID5037072 Css NA 1.655 mg/L 3compartmentss NA 50% Human Human +DTXSID5037072 Css NA 7.44 mg/L 3compartmentss NA 95% Human Human +DTXSID5037072 Css NA 1.216 mg/L PBTK NA 50% Human Human +DTXSID5037072 Css NA 4.672 mg/L PBTK NA 95% Human Human +DTXSID5037072 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037072 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037072 Vd NA 0.4704 L/kg 1compartment NA NA Rat Human DTXSID5037072 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5037072 TK.Half.Life NA 4.492 hours 1compartment NA NA Rat Human -DTXSID5037072 Css NA 0.9029 mg/L 3compartmentss NA 50% Rat Human -DTXSID5037072 Css NA 2.901 mg/L 3compartmentss NA 95% Rat Human -DTXSID5037072 Css NA 0.6026 mg/L PBTK NA 50% Rat Human -DTXSID5037072 Css NA 1.695 mg/L PBTK NA 95% Rat Human +DTXSID5037072 TK.Half.Life NA 2.406 hours 1compartment NA NA Rat Human +DTXSID5037072 Css NA 0.1056 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037072 Css NA 0.4004 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037072 Css NA 0.07631 mg/L PBTK NA 50% Rat Human +DTXSID5037072 Css NA 0.2445 mg/L PBTK NA 95% Rat Human +DTXSID5037236 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037236 Fup 0.835 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037236 Vd NA 0.4432 L/kg 1compartment NA NA Human Human +DTXSID5037236 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5037236 TK.Half.Life NA 3.433 hours 1compartment NA NA Human Human +DTXSID5037236 Css NA 0.9385 mg/L 3compartmentss NA 50% Human Human +DTXSID5037236 Css NA 5.155 mg/L 3compartmentss NA 95% Human Human +DTXSID5037236 Css NA 0.6866 mg/L PBTK NA 50% Human Human +DTXSID5037236 Css NA 3.222 mg/L PBTK NA 95% Human Human +DTXSID5037236 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037236 Fup 0.835 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037236 Vd NA 0.4712 L/kg 1compartment NA NA Rat Human +DTXSID5037236 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5037236 TK.Half.Life NA 1.244 hours 1compartment NA NA Rat Human +DTXSID5037236 Css NA 0.0246 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037236 Css NA 0.1529 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037236 Css NA 0.01722 mg/L PBTK NA 50% Rat Human +DTXSID5037236 Css NA 0.09359 mg/L PBTK NA 95% Rat Human DTXSID5037494 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5037494 Fup 0.486 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5037494 Vd NA 0.6827 L/kg 1compartment NA NA Human Human DTXSID5037494 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5037494 TK.Half.Life NA 9.292 hours 1compartment NA NA Human Human -DTXSID5037494 Css NA 0.796 mg/L 3compartmentss NA 50% Human Human -DTXSID5037494 Css NA 3.279 mg/L 3compartmentss NA 95% Human Human -DTXSID5037494 Css NA 0.6482 mg/L PBTK NA 50% Human Human -DTXSID5037494 Css NA 2.315 mg/L PBTK NA 95% Human Human +DTXSID5037494 Css NA 0.7775 mg/L 3compartmentss NA 50% Human Human +DTXSID5037494 Css NA 3.194 mg/L 3compartmentss NA 95% Human Human +DTXSID5037494 Css NA 0.6322 mg/L PBTK NA 50% Human Human +DTXSID5037494 Css NA 2.23 mg/L PBTK NA 95% Human Human DTXSID5037494 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5037494 Fup 0.486 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5037494 Vd NA 0.6369 L/kg 1compartment NA NA Rat Human DTXSID5037494 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5037494 TK.Half.Life NA 2.904 hours 1compartment NA NA Rat Human -DTXSID5037494 Css NA 0.2602 mg/L 3compartmentss NA 50% Rat Human -DTXSID5037494 Css NA 0.7337 mg/L 3compartmentss NA 95% Rat Human -DTXSID5037494 Css NA 0.2097 mg/L PBTK NA 50% Rat Human -DTXSID5037494 Css NA 0.4812 mg/L PBTK NA 95% Rat Human -DTXSID5037498 Clint NA 56.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037498 Fup NA 0.0273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037498 Vd NA 1.592 L/kg 1compartment NA NA Human Human +DTXSID5037494 Css NA 0.05834 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037494 Css NA 0.1663 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037494 Css NA 0.04872 mg/L PBTK NA 50% Rat Human +DTXSID5037494 Css NA 0.1127 mg/L PBTK NA 95% Rat Human +DTXSID5037498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037498 Fup 0.0394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037498 Vd NA 1.839 L/kg 1compartment NA NA Human Human DTXSID5037498 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5037498 TK.Half.Life NA 5.484 hours 1compartment NA NA Human Human -DTXSID5037498 Css NA 0.4461 mg/L 3compartmentss NA 50% Human Human -DTXSID5037498 Css NA 4.065 mg/L 3compartmentss NA 95% Human Human -DTXSID5037498 Css NA 0.2812 mg/L PBTK NA 50% Human Human -DTXSID5037498 Css NA 2.495 mg/L PBTK NA 95% Human Human -DTXSID5037498 Clint NA 56.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037498 Fup NA 0.0273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037498 Vd NA 1.185 L/kg 1compartment NA NA Rat Human +DTXSID5037498 TK.Half.Life NA 11.2 hours 1compartment NA NA Human Human +DTXSID5037498 Css NA 0.8527 mg/L 3compartmentss NA 50% Human Human +DTXSID5037498 Css NA 7.148 mg/L 3compartmentss NA 95% Human Human +DTXSID5037498 Css NA 0.549 mg/L PBTK NA 50% Human Human +DTXSID5037498 Css NA 4.448 mg/L PBTK NA 95% Human Human +DTXSID5037498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037498 Fup 0.0394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037498 Vd NA 1.375 L/kg 1compartment NA NA Rat Human DTXSID5037498 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5037498 TK.Half.Life NA 2.029 hours 1compartment NA NA Rat Human -DTXSID5037498 Css NA 0.2508 mg/L 3compartmentss NA 50% Rat Human -DTXSID5037498 Css NA 1.901 mg/L 3compartmentss NA 95% Rat Human -DTXSID5037498 Css NA 0.1491 mg/L PBTK NA 50% Rat Human -DTXSID5037498 Css NA 1.08 mg/L PBTK NA 95% Rat Human +DTXSID5037498 TK.Half.Life NA 3.87 hours 1compartment NA NA Rat Human +DTXSID5037498 Css NA 0.1109 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037498 Css NA 0.7286 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037498 Css NA 0.06972 mg/L PBTK NA 50% Rat Human +DTXSID5037498 Css NA 0.434 mg/L PBTK NA 95% Rat Human DTXSID5037523 Clint 34.62 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5037523 Fup 0.3269 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID5037523 Vd NA 1.508 L/kg 1compartment NA NA Human Human DTXSID5037523 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5037523 TK.Half.Life NA 1.475 hours 1compartment NA NA Human Human -DTXSID5037523 Css NA 0.04332 mg/L 3compartmentss NA 50% Human Human -DTXSID5037523 Css NA 0.3176 mg/L 3compartmentss NA 95% Human Human -DTXSID5037523 Css NA 0.03601 mg/L PBTK NA 50% Human Human -DTXSID5037523 Css NA 0.2351 mg/L PBTK NA 95% Human Human +DTXSID5037523 Css NA 0.03678 mg/L 3compartmentss NA 50% Human Human +DTXSID5037523 Css NA 0.2435 mg/L 3compartmentss NA 95% Human Human +DTXSID5037523 Css NA 0.03358 mg/L PBTK NA 50% Human Human +DTXSID5037523 Css NA 0.2227 mg/L PBTK NA 95% Human Human DTXSID5037523 Clint 59.02 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID5037523 Fup 0.3279 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID5037523 Vd NA 1.229 L/kg 1compartment NA NA Rat Rat +DTXSID5037523 Vd 2.4 1.229 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID5037523 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID5037523 TK.Half.Life NA 0.4731 hours 1compartment NA NA Rat Rat -DTXSID5037523 Css NA 0.01375 mg/L 3compartmentss NA 50% Rat Rat -DTXSID5037523 Css NA 0.08535 mg/L 3compartmentss NA 95% Rat Rat -DTXSID5037523 Css NA 0.01119 mg/L PBTK NA 50% Rat Rat -DTXSID5037523 Css NA 0.05979 mg/L PBTK NA 95% Rat Rat -DTXSID5037527 Clint NA 114.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037527 Fup NA 0.0858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037527 Vd NA 1.662 L/kg 1compartment NA NA Human Human +DTXSID5037523 TK.Half.Life 2.9 0.4731 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID5037523 Css 0.072 0.002578 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID5037523 Css 0.072 0.01558 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID5037523 Css 0.072 0.002452 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID5037523 Css 0.072 0.0148 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID5037527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037527 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037527 Vd NA 1.903 L/kg 1compartment NA NA Human Human DTXSID5037527 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5037527 TK.Half.Life NA 2.189 hours 1compartment NA NA Human Human -DTXSID5037527 Css NA 0.07588 mg/L 3compartmentss NA 50% Human Human -DTXSID5037527 Css NA 0.6067 mg/L 3compartmentss NA 95% Human Human -DTXSID5037527 Css NA 0.05062 mg/L PBTK NA 50% Human Human -DTXSID5037527 Css NA 0.3842 mg/L PBTK NA 95% Human Human -DTXSID5037527 Clint NA 114.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037527 Fup NA 0.0858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037527 Vd NA 1.261 L/kg 1compartment NA NA Rat Human +DTXSID5037527 TK.Half.Life NA 5.311 hours 1compartment NA NA Human Human +DTXSID5037527 Css NA 0.2828 mg/L 3compartmentss NA 50% Human Human +DTXSID5037527 Css NA 2.01 mg/L 3compartmentss NA 95% Human Human +DTXSID5037527 Css NA 0.1936 mg/L PBTK NA 50% Human Human +DTXSID5037527 Css NA 1.31 mg/L PBTK NA 95% Human Human +DTXSID5037527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037527 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037527 Vd NA 1.451 L/kg 1compartment NA NA Rat Human DTXSID5037527 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5037527 TK.Half.Life NA 0.7714 hours 1compartment NA NA Rat Human -DTXSID5037527 Css NA 0.0431 mg/L 3compartmentss NA 50% Rat Human -DTXSID5037527 Css NA 0.2791 mg/L 3compartmentss NA 95% Rat Human -DTXSID5037527 Css NA 0.02685 mg/L PBTK NA 50% Rat Human -DTXSID5037527 Css NA 0.1662 mg/L PBTK NA 95% Rat Human -DTXSID5037577 Clint NA 694.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037577 Fup NA 0.0159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037577 Vd NA 3.111 L/kg 1compartment NA NA Human Human -DTXSID5037577 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5037577 TK.Half.Life NA 5.291 hours 1compartment NA NA Human Human -DTXSID5037577 Css NA 0.1095 mg/L 3compartmentss NA 50% Human Human -DTXSID5037577 Css NA 0.6596 mg/L 3compartmentss NA 95% Human Human -DTXSID5037577 Css NA 0.076 mg/L PBTK NA 50% Human Human -DTXSID5037577 Css NA 0.4458 mg/L PBTK NA 95% Human Human -DTXSID5037577 Clint NA 694.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037577 Fup NA 0.0159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037577 Vd NA 2.331 L/kg 1compartment NA NA Rat Human -DTXSID5037577 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5037577 TK.Half.Life NA 1.197 hours 1compartment NA NA Rat Human -DTXSID5037577 Css NA 0.06212 mg/L 3compartmentss NA 50% Rat Human -DTXSID5037577 Css NA 0.2759 mg/L 3compartmentss NA 95% Rat Human -DTXSID5037577 Css NA 0.04109 mg/L PBTK NA 50% Rat Human -DTXSID5037577 Css NA 0.1819 mg/L PBTK NA 95% Rat Human -DTXSID5037579 Clint NA 52.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037579 Fup NA 0.0836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5037579 Vd NA 0.6449 L/kg 1compartment NA NA Human Human +DTXSID5037527 TK.Half.Life NA 1.836 hours 1compartment NA NA Rat Human +DTXSID5037527 Css NA 0.03661 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037527 Css NA 0.2074 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037527 Css NA 0.02463 mg/L PBTK NA 50% Rat Human +DTXSID5037527 Css NA 0.1327 mg/L PBTK NA 95% Rat Human +DTXSID5037571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037571 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037571 Vd NA 0.557 L/kg 1compartment NA NA Human Human +DTXSID5037571 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5037571 TK.Half.Life NA 0.7273 hours 1compartment NA NA Human Human +DTXSID5037571 Css NA 0.06673 mg/L 3compartmentss NA 50% Human Human +DTXSID5037571 Css NA 0.5278 mg/L 3compartmentss NA 95% Human Human +DTXSID5037571 Css NA 0.04652 mg/L PBTK NA 50% Human Human +DTXSID5037571 Css NA 0.3451 mg/L PBTK NA 95% Human Human +DTXSID5037571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037571 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037571 Vd NA 0.5175 L/kg 1compartment NA NA Rat Human +DTXSID5037571 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5037571 TK.Half.Life NA 0.3544 hours 1compartment NA NA Rat Human +DTXSID5037571 Css NA 0.008475 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037571 Css NA 0.04906 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037571 Css NA 0.005827 mg/L PBTK NA 50% Rat Human +DTXSID5037571 Css NA 0.03103 mg/L PBTK NA 95% Rat Human +DTXSID5037577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037577 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037577 Vd NA 2.729 L/kg 1compartment NA NA Human Human +DTXSID5037577 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5037577 TK.Half.Life NA 35.67 hours 1compartment NA NA Human Human +DTXSID5037577 Css NA 1.501 mg/L 3compartmentss NA 50% Human Human +DTXSID5037577 Css NA 11.18 mg/L 3compartmentss NA 95% Human Human +DTXSID5037577 Css NA 1.01 mg/L PBTK NA 50% Human Human +DTXSID5037577 Css NA 7.253 mg/L PBTK NA 95% Human Human +DTXSID5037577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037577 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037577 Vd NA 2.039 L/kg 1compartment NA NA Rat Human +DTXSID5037577 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5037577 TK.Half.Life NA 7.466 hours 1compartment NA NA Rat Human +DTXSID5037577 Css NA 0.0766 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037577 Css NA 0.5688 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037577 Css NA 0.05018 mg/L PBTK NA 50% Rat Human +DTXSID5037577 Css NA 0.3544 mg/L PBTK NA 95% Rat Human +DTXSID5037579 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037579 Fup 0.0908 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5037579 Vd NA 0.6248 L/kg 1compartment NA NA Human Human DTXSID5037579 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5037579 TK.Half.Life NA 1.124 hours 1compartment NA NA Human Human -DTXSID5037579 Css NA 0.149 mg/L 3compartmentss NA 50% Human Human -DTXSID5037579 Css NA 1.233 mg/L 3compartmentss NA 95% Human Human -DTXSID5037579 Css NA 0.09364 mg/L PBTK NA 50% Human Human -DTXSID5037579 Css NA 0.7455 mg/L PBTK NA 95% Human Human -DTXSID5037579 Clint NA 52.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037579 Fup NA 0.0836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5037579 Vd NA 0.5174 L/kg 1compartment NA NA Rat Human +DTXSID5037579 TK.Half.Life NA 1.722 hours 1compartment NA NA Human Human +DTXSID5037579 Css NA 0.3117 mg/L 3compartmentss NA 50% Human Human +DTXSID5037579 Css NA 2.427 mg/L 3compartmentss NA 95% Human Human +DTXSID5037579 Css NA 0.1956 mg/L PBTK NA 50% Human Human +DTXSID5037579 Css NA 1.477 mg/L PBTK NA 95% Human Human +DTXSID5037579 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037579 Fup 0.0908 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5037579 Vd NA 0.506 L/kg 1compartment NA NA Rat Human DTXSID5037579 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5037579 TK.Half.Life NA 0.4923 hours 1compartment NA NA Rat Human -DTXSID5037579 Css NA 0.08595 mg/L 3compartmentss NA 50% Rat Human -DTXSID5037579 Css NA 0.5543 mg/L 3compartmentss NA 95% Rat Human -DTXSID5037579 Css NA 0.05043 mg/L PBTK NA 50% Rat Human -DTXSID5037579 Css NA 0.3123 mg/L PBTK NA 95% Rat Human +DTXSID5037579 TK.Half.Life NA 0.8134 hours 1compartment NA NA Rat Human +DTXSID5037579 Css NA 0.04109 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037579 Css NA 0.2525 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037579 Css NA 0.02507 mg/L PBTK NA 50% Rat Human +DTXSID5037579 Css NA 0.1467 mg/L PBTK NA 95% Rat Human DTXSID5037731 Clint 22.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5037731 Fup 1.24e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5037731 Vd NA 0.2121 L/kg 1compartment NA NA Human Human -DTXSID5037731 Days.Css NA 51 Days PBTK NA NA Human Human -DTXSID5037731 TK.Half.Life NA 215.6 hours 1compartment NA NA Human Human -DTXSID5037731 Css NA 79.85 mg/L 3compartmentss NA 50% Human Human -DTXSID5037731 Css NA 445.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5037731 Css NA 46.56 mg/L PBTK NA 50% Human Human -DTXSID5037731 Css NA 254.6 mg/L PBTK NA 95% Human Human +DTXSID5037731 Vd NA 0.2671 L/kg 1compartment NA NA Human Human +DTXSID5037731 Days.Css NA 47 Days PBTK NA NA Human Human +DTXSID5037731 TK.Half.Life NA 201.3 hours 1compartment NA NA Human Human +DTXSID5037731 Css NA 58.75 mg/L 3compartmentss NA 50% Human Human +DTXSID5037731 Css NA 345.9 mg/L 3compartmentss NA 95% Human Human +DTXSID5037731 Css NA 34.3 mg/L PBTK NA 50% Human Human +DTXSID5037731 Css NA 199.2 mg/L PBTK NA 95% Human Human DTXSID5037731 Clint 22.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5037731 Fup 1.24e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5037731 Vd NA 0.1853 L/kg 1compartment NA NA Rat Human -DTXSID5037731 Days.Css NA 29 Days PBTK NA NA Rat Human -DTXSID5037731 TK.Half.Life NA 130 hours 1compartment NA NA Rat Human -DTXSID5037731 Css NA 55.44 mg/L 3compartmentss NA 50% Rat Human -DTXSID5037731 Css NA 166.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID5037731 Css NA 29.99 mg/L PBTK NA 50% Rat Human -DTXSID5037731 Css NA 90.16 mg/L PBTK NA 95% Rat Human +DTXSID5037731 Vd NA 0.2176 L/kg 1compartment NA NA Rat Human +DTXSID5037731 Days.Css NA 25 Days PBTK NA NA Rat Human +DTXSID5037731 TK.Half.Life NA 113.7 hours 1compartment NA NA Rat Human +DTXSID5037731 Css NA 9.341 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037731 Css NA 29.65 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037731 Css NA 5.239 mg/L PBTK NA 50% Rat Human +DTXSID5037731 Css NA 16.63 mg/L PBTK NA 95% Rat Human DTXSID5037739 Clint 75.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5037739 Fup 0.0582 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5037739 Vd NA 1.283 L/kg 1compartment NA NA Human Human DTXSID5037739 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5037739 TK.Half.Life NA 2.314 hours 1compartment NA NA Human Human -DTXSID5037739 Css NA 0.1186 mg/L 3compartmentss NA 50% Human Human -DTXSID5037739 Css NA 0.8435 mg/L 3compartmentss NA 95% Human Human -DTXSID5037739 Css NA 0.07748 mg/L PBTK NA 50% Human Human -DTXSID5037739 Css NA 0.5284 mg/L PBTK NA 95% Human Human +DTXSID5037739 Css NA 0.1106 mg/L 3compartmentss NA 50% Human Human +DTXSID5037739 Css NA 0.8566 mg/L 3compartmentss NA 95% Human Human +DTXSID5037739 Css NA 0.07223 mg/L PBTK NA 50% Human Human +DTXSID5037739 Css NA 0.5317 mg/L PBTK NA 95% Human Human DTXSID5037739 Clint 75.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5037739 Fup 0.0582 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5037739 Vd NA 0.9726 L/kg 1compartment NA NA Rat Human DTXSID5037739 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5037739 TK.Half.Life NA 0.8933 hours 1compartment NA NA Rat Human -DTXSID5037739 Css NA 0.06687 mg/L 3compartmentss NA 50% Rat Human -DTXSID5037739 Css NA 0.3709 mg/L 3compartmentss NA 95% Rat Human -DTXSID5037739 Css NA 0.04102 mg/L PBTK NA 50% Rat Human -DTXSID5037739 Css NA 0.2236 mg/L PBTK NA 95% Rat Human +DTXSID5037739 Css NA 0.01498 mg/L 3compartmentss NA 50% Rat Human +DTXSID5037739 Css NA 0.08909 mg/L 3compartmentss NA 95% Rat Human +DTXSID5037739 Css NA 0.009545 mg/L PBTK NA 50% Rat Human +DTXSID5037739 Css NA 0.05411 mg/L PBTK NA 95% Rat Human +DTXSID5038830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5038830 Fup 0.0205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5038830 Vd NA 2.894 L/kg 1compartment NA NA Human Human +DTXSID5038830 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID5038830 TK.Half.Life NA 49.23 hours 1compartment NA NA Human Human +DTXSID5038830 Css NA 2.182 mg/L 3compartmentss NA 50% Human Human +DTXSID5038830 Css NA 14.77 mg/L 3compartmentss NA 95% Human Human +DTXSID5038830 Css NA 1.486 mg/L PBTK NA 50% Human Human +DTXSID5038830 Css NA 9.611 mg/L PBTK NA 95% Human Human +DTXSID5038830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5038830 Fup 0.0205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5038830 Vd NA 2.164 L/kg 1compartment NA NA Rat Human +DTXSID5038830 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5038830 TK.Half.Life NA 8.833 hours 1compartment NA NA Rat Human +DTXSID5038830 Css NA 0.2818 mg/L 3compartmentss NA 50% Rat Human +DTXSID5038830 Css NA 1.606 mg/L 3compartmentss NA 95% Rat Human +DTXSID5038830 Css NA 0.1899 mg/L PBTK NA 50% Rat Human +DTXSID5038830 Css NA 1.039 mg/L PBTK NA 95% Rat Human DTXSID5038888 Clint 3.21 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5038888 Fup 1.56e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5038888 Vd NA 0.3856 L/kg 1compartment NA NA Human Human -DTXSID5038888 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID5038888 TK.Half.Life NA 104.1 hours 1compartment NA NA Human Human -DTXSID5038888 Css NA 21.3 mg/L 3compartmentss NA 50% Human Human -DTXSID5038888 Css NA 126.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5038888 Css NA 12.6 mg/L PBTK NA 50% Human Human -DTXSID5038888 Css NA 72.89 mg/L PBTK NA 95% Human Human +DTXSID5038888 Vd NA 0.1812 L/kg 1compartment NA NA Human Human +DTXSID5038888 Days.Css NA 97 Days PBTK NA NA Human Human +DTXSID5038888 TK.Half.Life NA 385.1 hours 1compartment NA NA Human Human +DTXSID5038888 Css NA 43.58 mg/L 3compartmentss NA 50% Human Human +DTXSID5038888 Css NA 295.6 mg/L 3compartmentss NA 95% Human Human +DTXSID5038888 Css NA 25.39 mg/L PBTK NA 50% Human Human +DTXSID5038888 Css NA 170.4 mg/L PBTK NA 95% Human Human DTXSID5038888 Clint 3.21 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5038888 Fup 1.56e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5038888 Vd NA 0.3041 L/kg 1compartment NA NA Rat Human -DTXSID5038888 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID5038888 TK.Half.Life NA 57.33 hours 1compartment NA NA Rat Human -DTXSID5038888 Css NA 14.37 mg/L 3compartmentss NA 50% Rat Human -DTXSID5038888 Css NA 51.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID5038888 Css NA 7.857 mg/L PBTK NA 50% Rat Human -DTXSID5038888 Css NA 28.53 mg/L PBTK NA 95% Rat Human -DTXSID5038919 Clint NA 2.169 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5038919 Fup NA 0.4064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5038919 Vd NA 0.7296 L/kg 1compartment NA NA Human Human +DTXSID5038888 Vd NA 0.1733 L/kg 1compartment NA NA Rat Human +DTXSID5038888 Days.Css NA 61 Days PBTK NA NA Rat Human +DTXSID5038888 TK.Half.Life NA 250 hours 1compartment NA NA Rat Human +DTXSID5038888 Css NA 0.431 mg/L 3compartmentss NA 50% Rat Human +DTXSID5038888 Css NA 1.788 mg/L 3compartmentss NA 95% Rat Human +DTXSID5038888 Css NA 0.2336 mg/L PBTK NA 50% Rat Human +DTXSID5038888 Css NA 0.9694 mg/L PBTK NA 95% Rat Human +DTXSID5038919 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5038919 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5038919 Vd NA 0.6014 L/kg 1compartment NA NA Human Human DTXSID5038919 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5038919 TK.Half.Life NA 2.875 hours 1compartment NA NA Human Human -DTXSID5038919 Css NA 0.3998 mg/L 3compartmentss NA 50% Human Human -DTXSID5038919 Css NA 2.124 mg/L 3compartmentss NA 95% Human Human -DTXSID5038919 Css NA 0.304 mg/L PBTK NA 50% Human Human -DTXSID5038919 Css NA 1.398 mg/L PBTK NA 95% Human Human -DTXSID5038919 Clint NA 2.169 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5038919 Fup NA 0.4064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5038919 Vd NA 0.693 L/kg 1compartment NA NA Rat Human +DTXSID5038919 TK.Half.Life NA 0.7831 hours 1compartment NA NA Human Human +DTXSID5038919 Css NA 0.06616 mg/L 3compartmentss NA 50% Human Human +DTXSID5038919 Css NA 0.5175 mg/L 3compartmentss NA 95% Human Human +DTXSID5038919 Css NA 0.04708 mg/L PBTK NA 50% Human Human +DTXSID5038919 Css NA 0.337 mg/L PBTK NA 95% Human Human +DTXSID5038919 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5038919 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5038919 Vd NA 0.5741 L/kg 1compartment NA NA Rat Human DTXSID5038919 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5038919 TK.Half.Life NA 1.454 hours 1compartment NA NA Rat Human -DTXSID5038919 Css NA 0.1756 mg/L 3compartmentss NA 50% Rat Human -DTXSID5038919 Css NA 0.8251 mg/L 3compartmentss NA 95% Rat Human -DTXSID5038919 Css NA 0.129 mg/L PBTK NA 50% Rat Human -DTXSID5038919 Css NA 0.5002 mg/L PBTK NA 95% Rat Human +DTXSID5038919 TK.Half.Life NA 0.3952 hours 1compartment NA NA Rat Human +DTXSID5038919 Css NA 0.008462 mg/L 3compartmentss NA 50% Rat Human +DTXSID5038919 Css NA 0.04684 mg/L 3compartmentss NA 95% Rat Human +DTXSID5038919 Css NA 0.005968 mg/L PBTK NA 50% Rat Human +DTXSID5038919 Css NA 0.03068 mg/L PBTK NA 95% Rat Human DTXSID5039721 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5039721 Fup NA 0.0656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5039721 Vd NA 0.9994 L/kg 1compartment NA NA Human Human -DTXSID5039721 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID5039721 TK.Half.Life NA 113.9 hours 1compartment NA NA Human Human -DTXSID5039721 Css NA 16.63 mg/L 3compartmentss NA 50% Human Human -DTXSID5039721 Css NA 65.36 mg/L 3compartmentss NA 95% Human Human -DTXSID5039721 Css NA 10.56 mg/L PBTK NA 50% Human Human -DTXSID5039721 Css NA 38.57 mg/L PBTK NA 95% Human Human +DTXSID5039721 Vd NA 2.65 L/kg 1compartment NA NA Human Human +DTXSID5039721 Days.Css NA 274 Days PBTK NA NA Human Human +DTXSID5039721 TK.Half.Life NA 1075 hours 1compartment NA NA Human Human +DTXSID5039721 Css NA 43.2 mg/L 3compartmentss NA 50% Human Human +DTXSID5039721 Css NA 129.9 mg/L 3compartmentss NA 95% Human Human +DTXSID5039721 Css NA 29.78 mg/L PBTK NA 50% Human Human +DTXSID5039721 Css NA 82.71 mg/L PBTK NA 95% Human Human DTXSID5039721 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5039721 Fup NA 0.0656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5039721 Vd NA 0.7695 L/kg 1compartment NA NA Rat Human -DTXSID5039721 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5039721 TK.Half.Life NA 26.83 hours 1compartment NA NA Rat Human -DTXSID5039721 Css NA 4.678 mg/L 3compartmentss NA 50% Rat Human -DTXSID5039721 Css NA 14.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID5039721 Css NA 2.784 mg/L PBTK NA 50% Rat Human -DTXSID5039721 Css NA 8.33 mg/L PBTK NA 95% Rat Human +DTXSID5039721 Vd NA 1.988 L/kg 1compartment NA NA Rat Human +DTXSID5039721 Days.Css NA 67 Days PBTK NA NA Rat Human +DTXSID5039721 TK.Half.Life NA 116.4 hours 1compartment NA NA Rat Human +DTXSID5039721 Css NA 1.035 mg/L 3compartmentss NA 50% Rat Human +DTXSID5039721 Css NA 4.41 mg/L 3compartmentss NA 95% Rat Human +DTXSID5039721 Css NA 0.6877 mg/L PBTK NA 50% Rat Human +DTXSID5039721 Css NA 2.782 mg/L PBTK NA 95% Rat Human DTXSID5040413 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5040413 Fup NA 0.2253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040413 Vd NA 0.8149 L/kg 1compartment NA NA Human Human -DTXSID5040413 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5040413 TK.Half.Life NA 23.4 hours 1compartment NA NA Human Human -DTXSID5040413 Css NA 3.239 mg/L 3compartmentss NA 50% Human Human -DTXSID5040413 Css NA 12.52 mg/L 3compartmentss NA 95% Human Human -DTXSID5040413 Css NA 2.33 mg/L PBTK NA 50% Human Human -DTXSID5040413 Css NA 7.881 mg/L PBTK NA 95% Human Human +DTXSID5040413 Vd NA 0.555 L/kg 1compartment NA NA Human Human +DTXSID5040413 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5040413 TK.Half.Life NA 15.94 hours 1compartment NA NA Human Human +DTXSID5040413 Css NA 2.895 mg/L 3compartmentss NA 50% Human Human +DTXSID5040413 Css NA 11.18 mg/L 3compartmentss NA 95% Human Human +DTXSID5040413 Css NA 1.98 mg/L PBTK NA 50% Human Human +DTXSID5040413 Css NA 6.922 mg/L PBTK NA 95% Human Human DTXSID5040413 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5040413 Fup NA 0.2253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040413 Vd NA 0.8192 L/kg 1compartment NA NA Rat Human +DTXSID5040413 Vd NA 0.5597 L/kg 1compartment NA NA Rat Human DTXSID5040413 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5040413 TK.Half.Life NA 8.017 hours 1compartment NA NA Rat Human -DTXSID5040413 Css NA 0.8998 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040413 Css NA 2.901 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040413 Css NA 0.6167 mg/L PBTK NA 50% Rat Human -DTXSID5040413 Css NA 1.718 mg/L PBTK NA 95% Rat Human -DTXSID5040461 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040461 Fup NA 0.7691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040461 Vd NA 0.9937 L/kg 1compartment NA NA Human Human +DTXSID5040413 TK.Half.Life NA 5.479 hours 1compartment NA NA Rat Human +DTXSID5040413 Css NA 0.05288 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040413 Css NA 0.3045 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040413 Css NA 0.03466 mg/L PBTK NA 50% Rat Human +DTXSID5040413 Css NA 0.1875 mg/L PBTK NA 95% Rat Human +DTXSID5040461 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040461 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040461 Vd NA 0.8711 L/kg 1compartment NA NA Human Human DTXSID5040461 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5040461 TK.Half.Life NA 8.569 hours 1compartment NA NA Human Human -DTXSID5040461 Css NA 0.986 mg/L 3compartmentss NA 50% Human Human -DTXSID5040461 Css NA 6.25 mg/L 3compartmentss NA 95% Human Human -DTXSID5040461 Css NA 0.8481 mg/L PBTK NA 50% Human Human -DTXSID5040461 Css NA 4.044 mg/L PBTK NA 95% Human Human -DTXSID5040461 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040461 Fup NA 0.7691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040461 Vd NA 0.9623 L/kg 1compartment NA NA Rat Human +DTXSID5040461 TK.Half.Life NA 0.7968 hours 1compartment NA NA Human Human +DTXSID5040461 Css NA 0.027 mg/L 3compartmentss NA 50% Human Human +DTXSID5040461 Css NA 0.3311 mg/L 3compartmentss NA 95% Human Human +DTXSID5040461 Css NA 0.02195 mg/L PBTK NA 50% Human Human +DTXSID5040461 Css NA 0.2264 mg/L PBTK NA 95% Human Human +DTXSID5040461 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040461 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040461 Vd NA 0.8335 L/kg 1compartment NA NA Rat Human DTXSID5040461 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5040461 TK.Half.Life NA 2.776 hours 1compartment NA NA Rat Human -DTXSID5040461 Css NA 0.251 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040461 Css NA 1.601 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040461 Css NA 0.2111 mg/L PBTK NA 50% Rat Human -DTXSID5040461 Css NA 0.9696 mg/L PBTK NA 95% Rat Human -DTXSID5040465 Clint NA 83.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040465 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040465 Vd NA 21.42 L/kg 1compartment NA NA Human Human -DTXSID5040465 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID5040465 TK.Half.Life NA 84.6 hours 1compartment NA NA Human Human -DTXSID5040465 Css NA 0.2078 mg/L 3compartmentss NA 50% Human Human -DTXSID5040465 Css NA 3.864 mg/L 3compartmentss NA 95% Human Human -DTXSID5040465 Css NA 0.4171 mg/L PBTK NA 50% Human Human -DTXSID5040465 Css NA 4.084 mg/L PBTK NA 95% Human Human -DTXSID5040465 Clint NA 83.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040465 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040465 Vd NA 17.38 L/kg 1compartment NA NA Rat Human -DTXSID5040465 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID5040465 TK.Half.Life NA 41.76 hours 1compartment NA NA Rat Human -DTXSID5040465 Css NA 0.1086 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040465 Css NA 1.883 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040465 Css NA 0.2242 mg/L PBTK NA 50% Rat Human -DTXSID5040465 Css NA 1.899 mg/L PBTK NA 95% Rat Human -DTXSID5040540 Clint NA 30.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040540 Fup NA 0.8549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040540 Vd NA 0.7812 L/kg 1compartment NA NA Human Human +DTXSID5040461 TK.Half.Life NA 0.3788 hours 1compartment NA NA Rat Human +DTXSID5040461 Css NA 0.000969 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040461 Css NA 0.01379 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040461 Css NA 0.0007782 mg/L PBTK NA 50% Rat Human +DTXSID5040461 Css NA 0.009354 mg/L PBTK NA 95% Rat Human +DTXSID5040465 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040465 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040465 Vd NA 30.65 L/kg 1compartment NA NA Human Human +DTXSID5040465 Days.Css NA 53 Days PBTK NA NA Human Human +DTXSID5040465 TK.Half.Life NA 270.5 hours 1compartment NA NA Human Human +DTXSID5040465 Css NA 0.3218 mg/L 3compartmentss NA 50% Human Human +DTXSID5040465 Css NA 6.078 mg/L 3compartmentss NA 95% Human Human +DTXSID5040465 Css NA 0.936 mg/L PBTK NA 50% Human Human +DTXSID5040465 Css NA 8.398 mg/L PBTK NA 95% Human Human +DTXSID5040465 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040465 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040465 Vd NA 25.24 L/kg 1compartment NA NA Rat Human +DTXSID5040465 Days.Css NA 34 Days PBTK NA NA Rat Human +DTXSID5040465 TK.Half.Life NA 124.4 hours 1compartment NA NA Rat Human +DTXSID5040465 Css NA 0.03772 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040465 Css NA 0.6116 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040465 Css NA 0.1184 mg/L PBTK NA 50% Rat Human +DTXSID5040465 Css NA 0.8311 mg/L PBTK NA 95% Rat Human +DTXSID5040540 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040540 Fup 0.693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040540 Vd NA 0.6891 L/kg 1compartment NA NA Human Human DTXSID5040540 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5040540 TK.Half.Life NA 0.5554 hours 1compartment NA NA Human Human -DTXSID5040540 Css NA 0.01984 mg/L 3compartmentss NA 50% Human Human -DTXSID5040540 Css NA 0.2021 mg/L 3compartmentss NA 95% Human Human -DTXSID5040540 Css NA 0.0162 mg/L PBTK NA 50% Human Human -DTXSID5040540 Css NA 0.1395 mg/L PBTK NA 95% Human Human -DTXSID5040540 Clint NA 30.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040540 Fup NA 0.8549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040540 Vd NA 0.8136 L/kg 1compartment NA NA Rat Human +DTXSID5040540 TK.Half.Life NA 6.436 hours 1compartment NA NA Human Human +DTXSID5040540 Css NA 0.9604 mg/L 3compartmentss NA 50% Human Human +DTXSID5040540 Css NA 6.353 mg/L 3compartmentss NA 95% Human Human +DTXSID5040540 Css NA 0.7704 mg/L PBTK NA 50% Human Human +DTXSID5040540 Css NA 4.001 mg/L PBTK NA 95% Human Human +DTXSID5040540 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040540 Fup 0.693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040540 Vd NA 0.7161 L/kg 1compartment NA NA Rat Human DTXSID5040540 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5040540 TK.Half.Life NA 0.2716 hours 1compartment NA NA Rat Human -DTXSID5040540 Css NA 0.01005 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040540 Css NA 0.08771 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040540 Css NA 0.008105 mg/L PBTK NA 50% Rat Human -DTXSID5040540 Css NA 0.05869 mg/L PBTK NA 95% Rat Human +DTXSID5040540 TK.Half.Life NA 2.279 hours 1compartment NA NA Rat Human +DTXSID5040540 Css NA 0.02447 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040540 Css NA 0.1874 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040540 Css NA 0.01896 mg/L PBTK NA 50% Rat Human +DTXSID5040540 Css NA 0.118 mg/L PBTK NA 95% Rat Human DTXSID5040625 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5040625 Fup NA 0.1017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040625 Vd NA 0.5282 L/kg 1compartment NA NA Human Human -DTXSID5040625 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5040625 TK.Half.Life NA 34.25 hours 1compartment NA NA Human Human -DTXSID5040625 Css NA 9.898 mg/L 3compartmentss NA 50% Human Human -DTXSID5040625 Css NA 45.63 mg/L 3compartmentss NA 95% Human Human -DTXSID5040625 Css NA 6.247 mg/L PBTK NA 50% Human Human -DTXSID5040625 Css NA 27 mg/L PBTK NA 95% Human Human +DTXSID5040625 Vd NA 0.2458 L/kg 1compartment NA NA Human Human +DTXSID5040625 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5040625 TK.Half.Life NA 15.63 hours 1compartment NA NA Human Human +DTXSID5040625 Css NA 8.54 mg/L 3compartmentss NA 50% Human Human +DTXSID5040625 Css NA 40.58 mg/L 3compartmentss NA 95% Human Human +DTXSID5040625 Css NA 5.21 mg/L PBTK NA 50% Human Human +DTXSID5040625 Css NA 23.25 mg/L PBTK NA 95% Human Human DTXSID5040625 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5040625 Fup NA 0.1017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040625 Vd NA 0.4703 L/kg 1compartment NA NA Rat Human -DTXSID5040625 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5040625 TK.Half.Life NA 10.24 hours 1compartment NA NA Rat Human -DTXSID5040625 Css NA 2.767 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040625 Css NA 11.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040625 Css NA 1.638 mg/L PBTK NA 50% Rat Human -DTXSID5040625 Css NA 6.255 mg/L PBTK NA 95% Rat Human +DTXSID5040625 Vd NA 0.2533 L/kg 1compartment NA NA Rat Human +DTXSID5040625 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5040625 TK.Half.Life NA 5.492 hours 1compartment NA NA Rat Human +DTXSID5040625 Css NA 0.1575 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040625 Css NA 1.024 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040625 Css NA 0.0911 mg/L PBTK NA 50% Rat Human +DTXSID5040625 Css NA 0.578 mg/L PBTK NA 95% Rat Human DTXSID5040675 Clint 3.816 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5040675 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5040675 Vd NA 0.1763 L/kg 1compartment NA NA Human Human +DTXSID5040675 Vd NA 0.191 L/kg 1compartment NA NA Human Human DTXSID5040675 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5040675 TK.Half.Life NA 31.21 hours 1compartment NA NA Human Human -DTXSID5040675 Css NA 34.44 mg/L 3compartmentss NA 50% Human Human -DTXSID5040675 Css NA 263.2 mg/L 3compartmentss NA 95% Human Human -DTXSID5040675 Css NA 19.6 mg/L PBTK NA 50% Human Human -DTXSID5040675 Css NA 152.3 mg/L PBTK NA 95% Human Human +DTXSID5040675 TK.Half.Life NA 33.76 hours 1compartment NA NA Human Human +DTXSID5040675 Css NA 18.74 mg/L 3compartmentss NA 50% Human Human +DTXSID5040675 Css NA 156.8 mg/L 3compartmentss NA 95% Human Human +DTXSID5040675 Css NA 10.3 mg/L PBTK NA 50% Human Human +DTXSID5040675 Css NA 86.25 mg/L PBTK NA 95% Human Human DTXSID5040675 Clint 3.816 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID5040675 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5040675 Vd NA 0.1727 L/kg 1compartment NA NA Rat Human +DTXSID5040675 Vd NA 0.1862 L/kg 1compartment NA NA Rat Human DTXSID5040675 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5040675 TK.Half.Life NA 18.72 hours 1compartment NA NA Rat Human -DTXSID5040675 Css NA 17.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040675 Css NA 106.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040675 Css NA 9.228 mg/L PBTK NA 50% Rat Human -DTXSID5040675 Css NA 57.15 mg/L PBTK NA 95% Rat Human -DTXSID5040679 Clint NA 13.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040679 Fup NA 0.0313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040679 Vd NA 2.844 L/kg 1compartment NA NA Human Human -DTXSID5040679 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID5040679 TK.Half.Life NA 58.39 hours 1compartment NA NA Human Human -DTXSID5040679 Css NA 2.724 mg/L 3compartmentss NA 50% Human Human -DTXSID5040679 Css NA 18 mg/L 3compartmentss NA 95% Human Human -DTXSID5040679 Css NA 1.86 mg/L PBTK NA 50% Human Human -DTXSID5040679 Css NA 11.72 mg/L PBTK NA 95% Human Human -DTXSID5040679 Clint NA 13.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040679 Fup NA 0.0313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040679 Vd NA 2.129 L/kg 1compartment NA NA Rat Human -DTXSID5040679 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5040679 TK.Half.Life NA 10.88 hours 1compartment NA NA Rat Human -DTXSID5040679 Css NA 1.527 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040679 Css NA 7.875 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040679 Css NA 0.9908 mg/L PBTK NA 50% Rat Human -DTXSID5040679 Css NA 4.967 mg/L PBTK NA 95% Rat Human -DTXSID5040700 Clint NA 8.465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040700 Fup 0.7107 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID5040700 Vd NA 1.914 L/kg 1compartment NA NA Human Human -DTXSID5040700 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5040700 TK.Half.Life NA 2.497 hours 1compartment NA NA Human Human -DTXSID5040700 Css NA 0.0743 mg/L 3compartmentss NA 50% Human Human -DTXSID5040700 Css NA 0.4336 mg/L 3compartmentss NA 95% Human Human -DTXSID5040700 Css NA 0.06797 mg/L PBTK NA 50% Human Human -DTXSID5040700 Css NA 0.354 mg/L PBTK NA 95% Human Human -DTXSID5040700 Clint NA 8.465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040700 Fup 0.7107 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID5040700 Vd NA 1.605 L/kg 1compartment NA NA Rat Human -DTXSID5040700 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5040700 TK.Half.Life NA 0.9682 hours 1compartment NA NA Rat Human -DTXSID5040700 Css NA 0.03739 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040700 Css NA 0.159 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040700 Css NA 0.03373 mg/L PBTK NA 50% Rat Human -DTXSID5040700 Css NA 0.1263 mg/L PBTK NA 95% Rat Human -DTXSID5040704 Clint NA 1.251 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040704 Fup NA 0.522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040704 Vd NA 1.462 L/kg 1compartment NA NA Human Human -DTXSID5040704 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5040704 TK.Half.Life NA 7.254 hours 1compartment NA NA Human Human -DTXSID5040704 Css NA 0.4842 mg/L 3compartmentss NA 50% Human Human -DTXSID5040704 Css NA 2.9 mg/L 3compartmentss NA 95% Human Human -DTXSID5040704 Css NA 0.4076 mg/L PBTK NA 50% Human Human -DTXSID5040704 Css NA 1.944 mg/L PBTK NA 95% Human Human -DTXSID5040704 Clint NA 1.251 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040704 Fup NA 0.522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040704 Vd NA 1.247 L/kg 1compartment NA NA Rat Human -DTXSID5040704 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5040704 TK.Half.Life NA 2.773 hours 1compartment NA NA Rat Human -DTXSID5040704 Css NA 0.1975 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040704 Css NA 1.033 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040704 Css NA 0.1624 mg/L PBTK NA 50% Rat Human -DTXSID5040704 Css NA 0.6383 mg/L PBTK NA 95% Rat Human +DTXSID5040675 TK.Half.Life NA 20.16 hours 1compartment NA NA Rat Human +DTXSID5040675 Css NA 0.1747 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040675 Css NA 1.295 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040675 Css NA 0.09637 mg/L PBTK NA 50% Rat Human +DTXSID5040675 Css NA 0.7139 mg/L PBTK NA 95% Rat Human +DTXSID5040679 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040679 Fup 0.012 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040679 Vd NA 2.466 L/kg 1compartment NA NA Human Human +DTXSID5040679 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5040679 TK.Half.Life NA 39.45 hours 1compartment NA NA Human Human +DTXSID5040679 Css NA 2.255 mg/L 3compartmentss NA 50% Human Human +DTXSID5040679 Css NA 17.5 mg/L 3compartmentss NA 95% Human Human +DTXSID5040679 Css NA 1.484 mg/L PBTK NA 50% Human Human +DTXSID5040679 Css NA 11.01 mg/L PBTK NA 95% Human Human +DTXSID5040679 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040679 Fup 0.012 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040679 Vd NA 1.837 L/kg 1compartment NA NA Rat Human +DTXSID5040679 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5040679 TK.Half.Life NA 9.894 hours 1compartment NA NA Rat Human +DTXSID5040679 Css NA 0.294 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040679 Css NA 1.858 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040679 Css NA 0.1899 mg/L PBTK NA 50% Rat Human +DTXSID5040679 Css NA 1.158 mg/L PBTK NA 95% Rat Human +DTXSID5040704 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040704 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040704 Vd NA 1.444 L/kg 1compartment NA NA Human Human +DTXSID5040704 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5040704 TK.Half.Life NA 35.9 hours 1compartment NA NA Human Human +DTXSID5040704 Css NA 2.574 mg/L 3compartmentss NA 50% Human Human +DTXSID5040704 Css NA 9.909 mg/L 3compartmentss NA 95% Human Human +DTXSID5040704 Css NA 1.989 mg/L PBTK NA 50% Human Human +DTXSID5040704 Css NA 6.553 mg/L PBTK NA 95% Human Human +DTXSID5040704 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040704 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040704 Vd NA 1.182 L/kg 1compartment NA NA Rat Human +DTXSID5040704 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5040704 TK.Half.Life NA 8.494 hours 1compartment NA NA Rat Human +DTXSID5040704 Css NA 0.1626 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040704 Css NA 0.5265 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040704 Css NA 0.1248 mg/L PBTK NA 50% Rat Human +DTXSID5040704 Css NA 0.3348 mg/L PBTK NA 95% Rat Human DTXSID5040706 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5040706 Fup 2.63e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5040706 Vd NA 0.3526 L/kg 1compartment NA NA Human Human +DTXSID5040706 Vd NA 6.45 L/kg 1compartment NA NA Human Human DTXSID5040706 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID5040706 TK.Half.Life NA 22820 hours 1compartment NA NA Human Human -DTXSID5040706 Css NA 4795 mg/L 3compartmentss NA 50% Human Human -DTXSID5040706 Css NA 13710 mg/L 3compartmentss NA 95% Human Human -DTXSID5040706 Css NA 2876 mg/L PBTK NA 50% Human Human -DTXSID5040706 Css NA 7782 mg/L PBTK NA 95% Human Human +DTXSID5040706 TK.Half.Life NA 417600 hours 1compartment NA NA Human Human +DTXSID5040706 Css NA 4787 mg/L 3compartmentss NA 50% Human Human +DTXSID5040706 Css NA 9683 mg/L 3compartmentss NA 95% Human Human +DTXSID5040706 Css NA 4458 mg/L PBTK NA 50% Human Human +DTXSID5040706 Css NA 8853 mg/L PBTK NA 95% Human Human DTXSID5040706 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5040706 Fup 2.63e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5040706 Vd NA 0.2717 L/kg 1compartment NA NA Rat Human -DTXSID5040706 Days.Css NA 1655 Days PBTK NA NA Rat Human -DTXSID5040706 TK.Half.Life NA 5991 hours 1compartment NA NA Rat Human -DTXSID5040706 Css NA 1807 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040706 Css NA 2442 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040706 Css NA 982.5 mg/L PBTK NA 50% Rat Human -DTXSID5040706 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID5040706 Vd NA 4.979 L/kg 1compartment NA NA Rat Human +DTXSID5040706 Days.Css NA 11150 Days PBTK NA NA Rat Human +DTXSID5040706 TK.Half.Life NA 109800 hours 1compartment NA NA Rat Human +DTXSID5040706 Css NA 332 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040706 Css NA 332.7 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040706 Css NA 310.5 mg/L PBTK NA 50% Rat Human +DTXSID5040706 Css NA 311.2 mg/L PBTK NA 95% Rat Human DTXSID5040708 Clint 440 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5040708 Fup 0.00695 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5040708 Vd NA 1.883 L/kg 1compartment NA NA Human Human DTXSID5040708 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5040708 TK.Half.Life NA 3.388 hours 1compartment NA NA Human Human -DTXSID5040708 Css NA 0.1053 mg/L 3compartmentss NA 50% Human Human -DTXSID5040708 Css NA 0.8408 mg/L 3compartmentss NA 95% Human Human -DTXSID5040708 Css NA 0.06826 mg/L PBTK NA 50% Human Human -DTXSID5040708 Css NA 0.5329 mg/L PBTK NA 95% Human Human +DTXSID5040708 Css NA 0.0992 mg/L 3compartmentss NA 50% Human Human +DTXSID5040708 Css NA 0.8732 mg/L 3compartmentss NA 95% Human Human +DTXSID5040708 Css NA 0.06409 mg/L PBTK NA 50% Human Human +DTXSID5040708 Css NA 0.5567 mg/L PBTK NA 95% Human Human DTXSID5040708 Clint 440 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5040708 Fup 0.00695 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5040708 Vd NA 1.392 L/kg 1compartment NA NA Rat Human DTXSID5040708 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5040708 TK.Half.Life NA 1.126 hours 1compartment NA NA Rat Human -DTXSID5040708 Css NA 0.0613 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040708 Css NA 0.3995 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040708 Css NA 0.03793 mg/L PBTK NA 50% Rat Human -DTXSID5040708 Css NA 0.2365 mg/L PBTK NA 95% Rat Human -DTXSID5040750 Clint NA 2.899 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040750 Fup NA 0.1482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040750 Vd NA 1.011 L/kg 1compartment NA NA Human Human -DTXSID5040750 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5040750 TK.Half.Life NA 8.419 hours 1compartment NA NA Human Human -DTXSID5040750 Css NA 1.092 mg/L 3compartmentss NA 50% Human Human -DTXSID5040750 Css NA 6.688 mg/L 3compartmentss NA 95% Human Human -DTXSID5040750 Css NA 0.7366 mg/L PBTK NA 50% Human Human -DTXSID5040750 Css NA 4.13 mg/L PBTK NA 95% Human Human -DTXSID5040750 Clint NA 2.899 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040750 Fup NA 0.1482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040750 Vd NA 0.8657 L/kg 1compartment NA NA Rat Human -DTXSID5040750 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5040750 TK.Half.Life NA 3.932 hours 1compartment NA NA Rat Human -DTXSID5040750 Css NA 0.5423 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040750 Css NA 2.405 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040750 Css NA 0.3498 mg/L PBTK NA 50% Rat Human -DTXSID5040750 Css NA 1.39 mg/L PBTK NA 95% Rat Human -DTXSID5040758 Clint NA 12.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040758 Fup NA 0.0039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5040758 Vd NA 0.1818 L/kg 1compartment NA NA Human Human -DTXSID5040758 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5040758 TK.Half.Life NA 13.68 hours 1compartment NA NA Human Human -DTXSID5040758 Css NA 15.22 mg/L 3compartmentss NA 50% Human Human -DTXSID5040758 Css NA 108.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5040758 Css NA 8.905 mg/L PBTK NA 50% Human Human -DTXSID5040758 Css NA 62.5 mg/L PBTK NA 95% Human Human -DTXSID5040758 Clint NA 12.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040758 Fup NA 0.0039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5040758 Vd NA 0.1766 L/kg 1compartment NA NA Rat Human +DTXSID5040708 Css NA 0.01353 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040708 Css NA 0.09354 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040708 Css NA 0.008618 mg/L PBTK NA 50% Rat Human +DTXSID5040708 Css NA 0.05795 mg/L PBTK NA 95% Rat Human +DTXSID5040750 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040750 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040750 Vd NA 1.391 L/kg 1compartment NA NA Human Human +DTXSID5040750 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5040750 TK.Half.Life NA 34.28 hours 1compartment NA NA Human Human +DTXSID5040750 Css NA 2.516 mg/L 3compartmentss NA 50% Human Human +DTXSID5040750 Css NA 10.05 mg/L 3compartmentss NA 95% Human Human +DTXSID5040750 Css NA 1.961 mg/L PBTK NA 50% Human Human +DTXSID5040750 Css NA 6.585 mg/L PBTK NA 95% Human Human +DTXSID5040750 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040750 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040750 Vd NA 1.216 L/kg 1compartment NA NA Rat Human +DTXSID5040750 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5040750 TK.Half.Life NA 9.264 hours 1compartment NA NA Rat Human +DTXSID5040750 Css NA 0.1602 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040750 Css NA 0.5305 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040750 Css NA 0.1241 mg/L PBTK NA 50% Rat Human +DTXSID5040750 Css NA 0.3388 mg/L PBTK NA 95% Rat Human +DTXSID5040758 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040758 Fup 0.0219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5040758 Vd NA 0.5061 L/kg 1compartment NA NA Human Human +DTXSID5040758 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5040758 TK.Half.Life NA 4.216 hours 1compartment NA NA Human Human +DTXSID5040758 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human +DTXSID5040758 Css NA 13.36 mg/L 3compartmentss NA 95% Human Human +DTXSID5040758 Css NA 0.825 mg/L PBTK NA 50% Human Human +DTXSID5040758 Css NA 7.861 mg/L PBTK NA 95% Human Human +DTXSID5040758 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040758 Fup 0.0219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5040758 Vd NA 0.3936 L/kg 1compartment NA NA Rat Human DTXSID5040758 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5040758 TK.Half.Life NA 8.864 hours 1compartment NA NA Rat Human -DTXSID5040758 Css NA 8.479 mg/L 3compartmentss NA 50% Rat Human -DTXSID5040758 Css NA 45.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID5040758 Css NA 4.607 mg/L PBTK NA 50% Rat Human -DTXSID5040758 Css NA 24.51 mg/L PBTK NA 95% Rat Human -DTXSID5041148 Clint NA 0.3084 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041148 Fup NA 0.5036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041148 Vd NA 0.3935 L/kg 1compartment NA NA Human Human +DTXSID5040758 TK.Half.Life NA 2.089 hours 1compartment NA NA Rat Human +DTXSID5040758 Css NA 0.1777 mg/L 3compartmentss NA 50% Rat Human +DTXSID5040758 Css NA 1.398 mg/L 3compartmentss NA 95% Rat Human +DTXSID5040758 Css NA 0.1025 mg/L PBTK NA 50% Rat Human +DTXSID5040758 Css NA 0.7953 mg/L PBTK NA 95% Rat Human +DTXSID5041140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041140 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5041140 Vd NA 2.602 L/kg 1compartment NA NA Human Human +DTXSID5041140 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID5041140 TK.Half.Life NA 57.91 hours 1compartment NA NA Human Human +DTXSID5041140 Css NA 2.801 mg/L 3compartmentss NA 50% Human Human +DTXSID5041140 Css NA 20.17 mg/L 3compartmentss NA 95% Human Human +DTXSID5041140 Css NA 1.864 mg/L PBTK NA 50% Human Human +DTXSID5041140 Css NA 13.17 mg/L PBTK NA 95% Human Human +DTXSID5041140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041140 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5041140 Vd NA 1.954 L/kg 1compartment NA NA Rat Human +DTXSID5041140 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID5041140 TK.Half.Life NA 13.7 hours 1compartment NA NA Rat Human +DTXSID5041140 Css NA 0.1432 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041140 Css NA 1.124 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041140 Css NA 0.09285 mg/L PBTK NA 50% Rat Human +DTXSID5041140 Css NA 0.6878 mg/L PBTK NA 95% Rat Human +DTXSID5041148 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041148 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041148 Vd NA 0.4208 L/kg 1compartment NA NA Human Human DTXSID5041148 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041148 TK.Half.Life NA 3.378 hours 1compartment NA NA Human Human -DTXSID5041148 Css NA 1.015 mg/L 3compartmentss NA 50% Human Human -DTXSID5041148 Css NA 5.032 mg/L 3compartmentss NA 95% Human Human -DTXSID5041148 Css NA 0.7133 mg/L PBTK NA 50% Human Human -DTXSID5041148 Css NA 3.125 mg/L PBTK NA 95% Human Human -DTXSID5041148 Clint NA 0.3084 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041148 Fup NA 0.5036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041148 Vd NA 0.4043 L/kg 1compartment NA NA Rat Human +DTXSID5041148 TK.Half.Life NA 4.735 hours 1compartment NA NA Human Human +DTXSID5041148 Css NA 1.379 mg/L 3compartmentss NA 50% Human Human +DTXSID5041148 Css NA 8.88 mg/L 3compartmentss NA 95% Human Human +DTXSID5041148 Css NA 0.9876 mg/L PBTK NA 50% Human Human +DTXSID5041148 Css NA 5.479 mg/L PBTK NA 95% Human Human +DTXSID5041148 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041148 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041148 Vd NA 0.4327 L/kg 1compartment NA NA Rat Human DTXSID5041148 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041148 TK.Half.Life NA 1.422 hours 1compartment NA NA Rat Human -DTXSID5041148 Css NA 0.3418 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041148 Css NA 1.567 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041148 Css NA 0.2287 mg/L PBTK NA 50% Rat Human -DTXSID5041148 Css NA 0.8982 mg/L PBTK NA 95% Rat Human -DTXSID5041273 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041273 Fup NA 0.275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041273 Vd NA 0.4243 L/kg 1compartment NA NA Human Human +DTXSID5041148 TK.Half.Life NA 1.66 hours 1compartment NA NA Rat Human +DTXSID5041148 Css NA 0.08556 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041148 Css NA 0.4953 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041148 Css NA 0.06029 mg/L PBTK NA 50% Rat Human +DTXSID5041148 Css NA 0.2918 mg/L PBTK NA 95% Rat Human +DTXSID5041190 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041190 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041190 Vd NA 2.491 L/kg 1compartment NA NA Human Human +DTXSID5041190 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5041190 TK.Half.Life NA 6.849 hours 1compartment NA NA Human Human +DTXSID5041190 Css NA 0.2335 mg/L 3compartmentss NA 50% Human Human +DTXSID5041190 Css NA 1.515 mg/L 3compartmentss NA 95% Human Human +DTXSID5041190 Css NA 0.1684 mg/L PBTK NA 50% Human Human +DTXSID5041190 Css NA 1.047 mg/L PBTK NA 95% Human Human +DTXSID5041190 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041190 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041190 Vd NA 1.896 L/kg 1compartment NA NA Rat Human +DTXSID5041190 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5041190 TK.Half.Life NA 1.898 hours 1compartment NA NA Rat Human +DTXSID5041190 Css NA 0.02998 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041190 Css NA 0.1466 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041190 Css NA 0.02148 mg/L PBTK NA 50% Rat Human +DTXSID5041190 Css NA 0.1006 mg/L PBTK NA 95% Rat Human +DTXSID5041273 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041273 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041273 Vd NA 0.3544 L/kg 1compartment NA NA Human Human DTXSID5041273 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5041273 TK.Half.Life NA 9.983 hours 1compartment NA NA Human Human -DTXSID5041273 Css NA 2.798 mg/L 3compartmentss NA 50% Human Human -DTXSID5041273 Css NA 10.89 mg/L 3compartmentss NA 95% Human Human -DTXSID5041273 Css NA 1.919 mg/L PBTK NA 50% Human Human -DTXSID5041273 Css NA 6.711 mg/L PBTK NA 95% Human Human -DTXSID5041273 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041273 Fup NA 0.275 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041273 Vd NA 0.434 L/kg 1compartment NA NA Rat Human +DTXSID5041273 TK.Half.Life NA 10.42 hours 1compartment NA NA Human Human +DTXSID5041273 Css NA 1.956 mg/L 3compartmentss NA 50% Human Human +DTXSID5041273 Css NA 7.716 mg/L 3compartmentss NA 95% Human Human +DTXSID5041273 Css NA 1.287 mg/L PBTK NA 50% Human Human +DTXSID5041273 Css NA 4.754 mg/L PBTK NA 95% Human Human +DTXSID5041273 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041273 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041273 Vd NA 0.3652 L/kg 1compartment NA NA Rat Human DTXSID5041273 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041273 TK.Half.Life NA 3.48 hours 1compartment NA NA Rat Human -DTXSID5041273 Css NA 0.771 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041273 Css NA 2.545 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041273 Css NA 0.5036 mg/L PBTK NA 50% Rat Human -DTXSID5041273 Css NA 1.473 mg/L PBTK NA 95% Rat Human -DTXSID5041275 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041275 Fup NA 0.1014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041275 Vd NA 2.921 L/kg 1compartment NA NA Human Human -DTXSID5041275 Days.Css NA 408 Days PBTK NA NA Human Human -DTXSID5041275 TK.Half.Life NA 1551 hours 1compartment NA NA Human Human -DTXSID5041275 Css NA 63.14 mg/L 3compartmentss NA 50% Human Human -DTXSID5041275 Css NA 186 mg/L 3compartmentss NA 95% Human Human -DTXSID5041275 Css NA 44.03 mg/L PBTK NA 50% Human Human -DTXSID5041275 Css NA 120.6 mg/L PBTK NA 95% Human Human -DTXSID5041275 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041275 Fup NA 0.1014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041275 Vd NA 2.196 L/kg 1compartment NA NA Rat Human -DTXSID5041275 Days.Css NA 101 Days PBTK NA NA Rat Human -DTXSID5041275 TK.Half.Life NA 131.2 hours 1compartment NA NA Rat Human -DTXSID5041275 Css NA 17.14 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041275 Css NA 39.98 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041275 Css NA 11.45 mg/L PBTK NA 50% Rat Human -DTXSID5041275 Css NA 24.02 mg/L PBTK NA 95% Rat Human -DTXSID5041279 Clint NA 0.821 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041279 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041279 Vd NA 1.094 L/kg 1compartment NA NA Human Human +DTXSID5041273 TK.Half.Life NA 3.66 hours 1compartment NA NA Rat Human +DTXSID5041273 Css NA 0.0105 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041273 Css NA 0.0423 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041273 Css NA 0.006577 mg/L PBTK NA 50% Rat Human +DTXSID5041273 Css NA 0.02497 mg/L PBTK NA 95% Rat Human +DTXSID5041275 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041275 Fup 0.0604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041275 Vd NA 2.622 L/kg 1compartment NA NA Human Human +DTXSID5041275 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5041275 TK.Half.Life NA 18.21 hours 1compartment NA NA Human Human +DTXSID5041275 Css NA 0.8414 mg/L 3compartmentss NA 50% Human Human +DTXSID5041275 Css NA 5.418 mg/L 3compartmentss NA 95% Human Human +DTXSID5041275 Css NA 0.5732 mg/L PBTK NA 50% Human Human +DTXSID5041275 Css NA 3.562 mg/L PBTK NA 95% Human Human +DTXSID5041275 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041275 Fup 0.0604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041275 Vd NA 1.968 L/kg 1compartment NA NA Rat Human +DTXSID5041275 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5041275 TK.Half.Life NA 4.3 hours 1compartment NA NA Rat Human +DTXSID5041275 Css NA 0.1082 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041275 Css NA 0.5693 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041275 Css NA 0.07268 mg/L PBTK NA 50% Rat Human +DTXSID5041275 Css NA 0.3682 mg/L PBTK NA 95% Rat Human +DTXSID5041279 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041279 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041279 Vd NA 0.6561 L/kg 1compartment NA NA Human Human DTXSID5041279 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041279 TK.Half.Life NA 3.25 hours 1compartment NA NA Human Human -DTXSID5041279 Css NA 0.3298 mg/L 3compartmentss NA 50% Human Human -DTXSID5041279 Css NA 2.362 mg/L 3compartmentss NA 95% Human Human -DTXSID5041279 Css NA 0.2976 mg/L PBTK NA 50% Human Human -DTXSID5041279 Css NA 1.6 mg/L PBTK NA 95% Human Human -DTXSID5041279 Clint NA 0.821 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041279 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041279 Vd NA 1.076 L/kg 1compartment NA NA Rat Human +DTXSID5041279 TK.Half.Life NA 6.993 hours 1compartment NA NA Human Human +DTXSID5041279 Css NA 1.171 mg/L 3compartmentss NA 50% Human Human +DTXSID5041279 Css NA 8.099 mg/L 3compartmentss NA 95% Human Human +DTXSID5041279 Css NA 0.9406 mg/L PBTK NA 50% Human Human +DTXSID5041279 Css NA 5.107 mg/L PBTK NA 95% Human Human +DTXSID5041279 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041279 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041279 Vd NA 0.6768 L/kg 1compartment NA NA Rat Human DTXSID5041279 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041279 TK.Half.Life NA 1.474 hours 1compartment NA NA Rat Human -DTXSID5041279 Css NA 0.1183 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041279 Css NA 0.8213 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041279 Css NA 0.1059 mg/L PBTK NA 50% Rat Human -DTXSID5041279 Css NA 0.5095 mg/L PBTK NA 95% Rat Human +DTXSID5041279 TK.Half.Life NA 2.459 hours 1compartment NA NA Rat Human +DTXSID5041279 Css NA 0.07177 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041279 Css NA 0.4565 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041279 Css NA 0.05728 mg/L PBTK NA 50% Rat Human +DTXSID5041279 Css NA 0.2778 mg/L PBTK NA 95% Rat Human DTXSID5041306 Clint 19.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5041306 Fup 0.0354 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5041306 Vd NA 0.7107 L/kg 1compartment NA NA Human Human +DTXSID5041306 Vd NA 1.08 L/kg 1compartment NA NA Human Human DTXSID5041306 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041306 TK.Half.Life NA 4.395 hours 1compartment NA NA Human Human -DTXSID5041306 Css NA 0.7151 mg/L 3compartmentss NA 50% Human Human -DTXSID5041306 Css NA 5.578 mg/L 3compartmentss NA 95% Human Human -DTXSID5041306 Css NA 0.4403 mg/L PBTK NA 50% Human Human -DTXSID5041306 Css NA 3.295 mg/L PBTK NA 95% Human Human +DTXSID5041306 TK.Half.Life NA 6.822 hours 1compartment NA NA Human Human +DTXSID5041306 Css NA 0.7088 mg/L 3compartmentss NA 50% Human Human +DTXSID5041306 Css NA 5.408 mg/L 3compartmentss NA 95% Human Human +DTXSID5041306 Css NA 0.4471 mg/L PBTK NA 50% Human Human +DTXSID5041306 Css NA 3.273 mg/L PBTK NA 95% Human Human DTXSID5041306 Clint 19.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5041306 Fup 0.0354 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5041306 Vd NA 0.5467 L/kg 1compartment NA NA Rat Human +DTXSID5041306 Vd NA 0.8115 L/kg 1compartment NA NA Rat Human DTXSID5041306 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041306 TK.Half.Life NA 2.067 hours 1compartment NA NA Rat Human -DTXSID5041306 Css NA 0.412 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041306 Css NA 2.348 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041306 Css NA 0.2383 mg/L PBTK NA 50% Rat Human -DTXSID5041306 Css NA 1.312 mg/L PBTK NA 95% Rat Human -DTXSID5041308 Clint NA 15.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041308 Fup NA 0.0254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041308 Vd NA 2.617 L/kg 1compartment NA NA Human Human +DTXSID5041306 TK.Half.Life NA 0.831 hours 1compartment NA NA Rat Human +DTXSID5041306 Css NA 0.01792 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041306 Css NA 0.1232 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041306 Css NA 0.01102 mg/L PBTK NA 50% Rat Human +DTXSID5041306 Css NA 0.07312 mg/L PBTK NA 95% Rat Human +DTXSID5041308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041308 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041308 Vd NA 2.491 L/kg 1compartment NA NA Human Human DTXSID5041308 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5041308 TK.Half.Life NA 40.89 hours 1compartment NA NA Human Human -DTXSID5041308 Css NA 2.202 mg/L 3compartmentss NA 50% Human Human -DTXSID5041308 Css NA 14.76 mg/L 3compartmentss NA 95% Human Human -DTXSID5041308 Css NA 1.472 mg/L PBTK NA 50% Human Human -DTXSID5041308 Css NA 9.447 mg/L PBTK NA 95% Human Human -DTXSID5041308 Clint NA 15.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041308 Fup NA 0.0254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041308 Vd NA 1.955 L/kg 1compartment NA NA Rat Human -DTXSID5041308 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5041308 TK.Half.Life NA 9.249 hours 1compartment NA NA Rat Human -DTXSID5041308 Css NA 1.226 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041308 Css NA 6.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041308 Css NA 0.7803 mg/L PBTK NA 50% Rat Human -DTXSID5041308 Css NA 4.095 mg/L PBTK NA 95% Rat Human -DTXSID5041356 Clint NA 3.714 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041356 Fup NA 0.0201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041356 Vd NA 0.27 L/kg 1compartment NA NA Human Human -DTXSID5041356 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5041356 TK.Half.Life NA 12.27 hours 1compartment NA NA Human Human -DTXSID5041356 Css NA 8.084 mg/L 3compartmentss NA 50% Human Human -DTXSID5041356 Css NA 64.55 mg/L 3compartmentss NA 95% Human Human -DTXSID5041356 Css NA 4.876 mg/L PBTK NA 50% Human Human -DTXSID5041356 Css NA 37.95 mg/L PBTK NA 95% Human Human -DTXSID5041356 Clint NA 3.714 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041356 Fup NA 0.0201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041356 Vd NA 0.2608 L/kg 1compartment NA NA Rat Human -DTXSID5041356 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041356 TK.Half.Life NA 7.199 hours 1compartment NA NA Rat Human -DTXSID5041356 Css NA 4.146 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041356 Css NA 26.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041356 Css NA 2.327 mg/L PBTK NA 50% Rat Human -DTXSID5041356 Css NA 14.39 mg/L PBTK NA 95% Rat Human -DTXSID5041431 Clint NA 5.825 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041431 Fup NA 0.3241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041431 Vd NA 1.524 L/kg 1compartment NA NA Human Human +DTXSID5041308 TK.Half.Life NA 41.96 hours 1compartment NA NA Human Human +DTXSID5041308 Css NA 2.386 mg/L 3compartmentss NA 50% Human Human +DTXSID5041308 Css NA 17.28 mg/L 3compartmentss NA 95% Human Human +DTXSID5041308 Css NA 1.571 mg/L PBTK NA 50% Human Human +DTXSID5041308 Css NA 11.02 mg/L PBTK NA 95% Human Human +DTXSID5041308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041308 Fup 0.011 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041308 Vd NA 1.855 L/kg 1compartment NA NA Rat Human +DTXSID5041308 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5041308 TK.Half.Life NA 10.35 hours 1compartment NA NA Rat Human +DTXSID5041308 Css NA 0.3087 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041308 Css NA 2.003 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041308 Css NA 0.1997 mg/L PBTK NA 50% Rat Human +DTXSID5041308 Css NA 1.256 mg/L PBTK NA 95% Rat Human +DTXSID5041356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041356 Fup 0.032 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041356 Vd NA 0.2646 L/kg 1compartment NA NA Human Human +DTXSID5041356 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID5041356 TK.Half.Life NA 53.48 hours 1compartment NA NA Human Human +DTXSID5041356 Css NA 33.56 mg/L 3compartmentss NA 50% Human Human +DTXSID5041356 Css NA 194.2 mg/L 3compartmentss NA 95% Human Human +DTXSID5041356 Css NA 20.23 mg/L PBTK NA 50% Human Human +DTXSID5041356 Css NA 114.3 mg/L PBTK NA 95% Human Human +DTXSID5041356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041356 Fup 0.032 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041356 Vd NA 0.2585 L/kg 1compartment NA NA Rat Human +DTXSID5041356 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5041356 TK.Half.Life NA 17.81 hours 1compartment NA NA Rat Human +DTXSID5041356 Css NA 2.196 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041356 Css NA 10.94 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041356 Css NA 1.278 mg/L PBTK NA 50% Rat Human +DTXSID5041356 Css NA 6.173 mg/L PBTK NA 95% Rat Human +DTXSID5041431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041431 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041431 Vd NA 1.306 L/kg 1compartment NA NA Human Human DTXSID5041431 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041431 TK.Half.Life NA 4.332 hours 1compartment NA NA Human Human -DTXSID5041431 Css NA 0.256 mg/L 3compartmentss NA 50% Human Human -DTXSID5041431 Css NA 1.471 mg/L 3compartmentss NA 95% Human Human -DTXSID5041431 Css NA 0.1966 mg/L PBTK NA 50% Human Human -DTXSID5041431 Css NA 1.021 mg/L PBTK NA 95% Human Human -DTXSID5041431 Clint NA 5.825 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041431 Fup NA 0.3241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041431 Vd NA 1.237 L/kg 1compartment NA NA Rat Human +DTXSID5041431 TK.Half.Life NA 2.021 hours 1compartment NA NA Human Human +DTXSID5041431 Css NA 0.09563 mg/L 3compartmentss NA 50% Human Human +DTXSID5041431 Css NA 0.6943 mg/L 3compartmentss NA 95% Human Human +DTXSID5041431 Css NA 0.06986 mg/L PBTK NA 50% Human Human +DTXSID5041431 Css NA 0.466 mg/L PBTK NA 95% Human Human +DTXSID5041431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041431 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041431 Vd NA 1.056 L/kg 1compartment NA NA Rat Human DTXSID5041431 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041431 TK.Half.Life NA 1.749 hours 1compartment NA NA Rat Human -DTXSID5041431 Css NA 0.1294 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041431 Css NA 0.5717 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041431 Css NA 0.09596 mg/L PBTK NA 50% Rat Human -DTXSID5041431 Css NA 0.3769 mg/L PBTK NA 95% Rat Human +DTXSID5041431 TK.Half.Life NA 0.8305 hours 1compartment NA NA Rat Human +DTXSID5041431 Css NA 0.01198 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041431 Css NA 0.0677 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041431 Css NA 0.008671 mg/L PBTK NA 50% Rat Human +DTXSID5041431 Css NA 0.04497 mg/L PBTK NA 95% Rat Human DTXSID5041437 Clint NA 13.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5041437 Fup NA 0.9772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041437 Vd NA 0.7074 L/kg 1compartment NA NA Human Human +DTXSID5041437 Vd NA 0.7985 L/kg 1compartment NA NA Human Human DTXSID5041437 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041437 TK.Half.Life NA 0.5658 hours 1compartment NA NA Human Human -DTXSID5041437 Css NA 0.03656 mg/L 3compartmentss NA 50% Human Human -DTXSID5041437 Css NA 0.4344 mg/L 3compartmentss NA 95% Human Human -DTXSID5041437 Css NA 0.02973 mg/L PBTK NA 50% Human Human -DTXSID5041437 Css NA 0.3104 mg/L PBTK NA 95% Human Human +DTXSID5041437 TK.Half.Life NA 0.6301 hours 1compartment NA NA Human Human +DTXSID5041437 Css NA 0.02656 mg/L 3compartmentss NA 50% Human Human +DTXSID5041437 Css NA 0.3764 mg/L 3compartmentss NA 95% Human Human +DTXSID5041437 Css NA 0.02212 mg/L PBTK NA 50% Human Human +DTXSID5041437 Css NA 0.2755 mg/L PBTK NA 95% Human Human DTXSID5041437 Clint NA 13.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5041437 Fup NA 0.9772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041437 Vd NA 0.7525 L/kg 1compartment NA NA Rat Human +DTXSID5041437 Vd NA 0.8304 L/kg 1compartment NA NA Rat Human DTXSID5041437 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041437 TK.Half.Life NA 0.2947 hours 1compartment NA NA Rat Human -DTXSID5041437 Css NA 0.0179 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041437 Css NA 0.1842 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041437 Css NA 0.01447 mg/L PBTK NA 50% Rat Human -DTXSID5041437 Css NA 0.1201 mg/L PBTK NA 95% Rat Human -DTXSID5041439 Clint NA 4.395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041439 Fup NA 0.0671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041439 Vd NA 2.11 L/kg 1compartment NA NA Human Human -DTXSID5041439 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5041439 TK.Half.Life NA 38.36 hours 1compartment NA NA Human Human -DTXSID5041439 Css NA 2.696 mg/L 3compartmentss NA 50% Human Human -DTXSID5041439 Css NA 14.49 mg/L 3compartmentss NA 95% Human Human -DTXSID5041439 Css NA 1.798 mg/L PBTK NA 50% Human Human -DTXSID5041439 Css NA 9.282 mg/L PBTK NA 95% Human Human -DTXSID5041439 Clint NA 4.395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041439 Fup NA 0.0671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041439 Vd NA 1.586 L/kg 1compartment NA NA Rat Human -DTXSID5041439 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5041439 TK.Half.Life NA 11.21 hours 1compartment NA NA Rat Human -DTXSID5041439 Css NA 1.373 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041439 Css NA 5.529 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041439 Css NA 0.8704 mg/L PBTK NA 50% Rat Human -DTXSID5041439 Css NA 3.285 mg/L PBTK NA 95% Rat Human -DTXSID5041512 Clint NA 0.2919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041512 Fup NA 0.3023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041512 Vd NA 1.167 L/kg 1compartment NA NA Human Human -DTXSID5041512 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5041512 TK.Half.Life NA 18.93 hours 1compartment NA NA Human Human -DTXSID5041512 Css NA 1.738 mg/L 3compartmentss NA 50% Human Human -DTXSID5041512 Css NA 6.747 mg/L 3compartmentss NA 95% Human Human -DTXSID5041512 Css NA 1.31 mg/L PBTK NA 50% Human Human -DTXSID5041512 Css NA 4.393 mg/L PBTK NA 95% Human Human -DTXSID5041512 Clint NA 0.2919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041512 Fup NA 0.3023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041512 Vd NA 0.978 L/kg 1compartment NA NA Rat Human +DTXSID5041437 TK.Half.Life NA 0.3222 hours 1compartment NA NA Rat Human +DTXSID5041437 Css NA 0.0009065 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041437 Css NA 0.01344 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041437 Css NA 0.0007531 mg/L PBTK NA 50% Rat Human +DTXSID5041437 Css NA 0.009669 mg/L PBTK NA 95% Rat Human +DTXSID5041439 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041439 Fup 0.0349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041439 Vd NA 1.772 L/kg 1compartment NA NA Human Human +DTXSID5041439 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5041439 TK.Half.Life NA 11.54 hours 1compartment NA NA Human Human +DTXSID5041439 Css NA 0.9316 mg/L 3compartmentss NA 50% Human Human +DTXSID5041439 Css NA 6.529 mg/L 3compartmentss NA 95% Human Human +DTXSID5041439 Css NA 0.5925 mg/L PBTK NA 50% Human Human +DTXSID5041439 Css NA 4.038 mg/L PBTK NA 95% Human Human +DTXSID5041439 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041439 Fup 0.0349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041439 Vd NA 1.322 L/kg 1compartment NA NA Rat Human +DTXSID5041439 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5041439 TK.Half.Life NA 4.08 hours 1compartment NA NA Rat Human +DTXSID5041439 Css NA 0.1198 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041439 Css NA 0.6791 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041439 Css NA 0.07456 mg/L PBTK NA 50% Rat Human +DTXSID5041439 Css NA 0.4093 mg/L PBTK NA 95% Rat Human +DTXSID5041512 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041512 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041512 Vd NA 1.128 L/kg 1compartment NA NA Human Human +DTXSID5041512 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5041512 TK.Half.Life NA 1.538 hours 1compartment NA NA Human Human +DTXSID5041512 Css NA 0.07408 mg/L 3compartmentss NA 50% Human Human +DTXSID5041512 Css NA 0.5516 mg/L 3compartmentss NA 95% Human Human +DTXSID5041512 Css NA 0.05462 mg/L PBTK NA 50% Human Human +DTXSID5041512 Css NA 0.3762 mg/L PBTK NA 95% Human Human +DTXSID5041512 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041512 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041512 Vd NA 0.9447 L/kg 1compartment NA NA Rat Human DTXSID5041512 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041512 TK.Half.Life NA 5.914 hours 1compartment NA NA Rat Human -DTXSID5041512 Css NA 0.5825 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041512 Css NA 1.98 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041512 Css NA 0.4209 mg/L PBTK NA 50% Rat Human -DTXSID5041512 Css NA 1.199 mg/L PBTK NA 95% Rat Human +DTXSID5041512 TK.Half.Life NA 0.662 hours 1compartment NA NA Rat Human +DTXSID5041512 Css NA 0.009341 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041512 Css NA 0.05267 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041512 Css NA 0.006872 mg/L PBTK NA 50% Rat Human +DTXSID5041512 Css NA 0.03552 mg/L PBTK NA 95% Rat Human DTXSID5041516 Clint 81 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5041516 Fup 0.606 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5041516 Vd NA 0.5858 L/kg 1compartment NA NA Human Human DTXSID5041516 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5041516 TK.Half.Life NA 0.4426 hours 1compartment NA NA Human Human -DTXSID5041516 Css NA 0.009047 mg/L 3compartmentss NA 50% Human Human -DTXSID5041516 Css NA 0.06254 mg/L 3compartmentss NA 95% Human Human -DTXSID5041516 Css NA 0.006811 mg/L PBTK NA 50% Human Human -DTXSID5041516 Css NA 0.04454 mg/L PBTK NA 95% Human Human +DTXSID5041516 Css NA 0.007174 mg/L 3compartmentss NA 50% Human Human +DTXSID5041516 Css NA 0.05732 mg/L 3compartmentss NA 95% Human Human +DTXSID5041516 Css NA 0.005407 mg/L PBTK NA 50% Human Human +DTXSID5041516 Css NA 0.04107 mg/L PBTK NA 95% Human Human DTXSID5041516 Clint 81 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5041516 Fup 0.606 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5041516 Vd NA 0.5818 L/kg 1compartment NA NA Rat Human DTXSID5041516 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5041516 TK.Half.Life NA 0.1991 hours 1compartment NA NA Rat Human -DTXSID5041516 Css NA 0.00483 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041516 Css NA 0.02782 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041516 Css NA 0.003552 mg/L PBTK NA 50% Rat Human -DTXSID5041516 Css NA 0.01919 mg/L PBTK NA 95% Rat Human -DTXSID5041518 Clint NA 83.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041518 Fup NA 0.3743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041518 Vd NA 1.019 L/kg 1compartment NA NA Human Human +DTXSID5041516 Css NA 0.0009232 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041516 Css NA 0.005948 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041516 Css NA 0.0007128 mg/L PBTK NA 50% Rat Human +DTXSID5041516 Css NA 0.004157 mg/L PBTK NA 95% Rat Human +DTXSID5041518 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041518 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041518 Vd NA 1.124 L/kg 1compartment NA NA Human Human DTXSID5041518 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041518 TK.Half.Life NA 0.8377 hours 1compartment NA NA Human Human -DTXSID5041518 Css NA 0.01505 mg/L 3compartmentss NA 50% Human Human -DTXSID5041518 Css NA 0.1242 mg/L 3compartmentss NA 95% Human Human -DTXSID5041518 Css NA 0.01153 mg/L PBTK NA 50% Human Human -DTXSID5041518 Css NA 0.0838 mg/L PBTK NA 95% Human Human -DTXSID5041518 Clint NA 83.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041518 Fup NA 0.3743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041518 Vd NA 0.8938 L/kg 1compartment NA NA Rat Human +DTXSID5041518 TK.Half.Life NA 1.249 hours 1compartment NA NA Human Human +DTXSID5041518 Css NA 0.04866 mg/L 3compartmentss NA 50% Human Human +DTXSID5041518 Css NA 0.4031 mg/L 3compartmentss NA 95% Human Human +DTXSID5041518 Css NA 0.03829 mg/L PBTK NA 50% Human Human +DTXSID5041518 Css NA 0.2777 mg/L PBTK NA 95% Human Human +DTXSID5041518 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041518 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041518 Vd NA 0.976 L/kg 1compartment NA NA Rat Human DTXSID5041518 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041518 TK.Half.Life NA 0.3404 hours 1compartment NA NA Rat Human -DTXSID5041518 Css NA 0.008054 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041518 Css NA 0.05361 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041518 Css NA 0.006014 mg/L PBTK NA 50% Rat Human -DTXSID5041518 Css NA 0.03566 mg/L PBTK NA 95% Rat Human -DTXSID5041560 Clint NA 37.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041560 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041560 Vd NA 4.9 L/kg 1compartment NA NA Human Human -DTXSID5041560 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID5041560 TK.Half.Life NA 86.9 hours 1compartment NA NA Human Human -DTXSID5041560 Css NA 1.761 mg/L 3compartmentss NA 50% Human Human -DTXSID5041560 Css NA 9.597 mg/L 3compartmentss NA 95% Human Human -DTXSID5041560 Css NA 1.422 mg/L PBTK NA 50% Human Human -DTXSID5041560 Css NA 7.618 mg/L PBTK NA 95% Human Human -DTXSID5041560 Clint NA 37.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041560 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041560 Vd NA 3.739 L/kg 1compartment NA NA Rat Human -DTXSID5041560 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID5041560 TK.Half.Life NA 12.12 hours 1compartment NA NA Rat Human -DTXSID5041560 Css NA 0.9882 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041560 Css NA 4.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041560 Css NA 0.769 mg/L PBTK NA 50% Rat Human -DTXSID5041560 Css NA 3.147 mg/L PBTK NA 95% Rat Human -DTXSID5041641 Clint NA 0.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041641 Fup NA 0.1868 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041641 Vd NA 0.4104 L/kg 1compartment NA NA Human Human +DTXSID5041518 TK.Half.Life NA 0.5462 hours 1compartment NA NA Rat Human +DTXSID5041518 Css NA 0.00603 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041518 Css NA 0.03721 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041518 Css NA 0.004776 mg/L PBTK NA 50% Rat Human +DTXSID5041518 Css NA 0.02586 mg/L PBTK NA 95% Rat Human +DTXSID5041641 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041641 Fup 0.393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041641 Vd NA 0.5736 L/kg 1compartment NA NA Human Human DTXSID5041641 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041641 TK.Half.Life NA 6.876 hours 1compartment NA NA Human Human -DTXSID5041641 Css NA 1.988 mg/L 3compartmentss NA 50% Human Human -DTXSID5041641 Css NA 8.009 mg/L 3compartmentss NA 95% Human Human -DTXSID5041641 Css NA 1.336 mg/L PBTK NA 50% Human Human -DTXSID5041641 Css NA 4.873 mg/L PBTK NA 95% Human Human -DTXSID5041641 Clint NA 0.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041641 Fup NA 0.1868 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041641 Vd NA 0.4131 L/kg 1compartment NA NA Rat Human +DTXSID5041641 TK.Half.Life NA 1.157 hours 1compartment NA NA Human Human +DTXSID5041641 Css NA 0.1594 mg/L 3compartmentss NA 50% Human Human +DTXSID5041641 Css NA 1.126 mg/L 3compartmentss NA 95% Human Human +DTXSID5041641 Css NA 0.1198 mg/L PBTK NA 50% Human Human +DTXSID5041641 Css NA 0.746 mg/L PBTK NA 95% Human Human +DTXSID5041641 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041641 Fup 0.393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041641 Vd NA 0.5835 L/kg 1compartment NA NA Rat Human DTXSID5041641 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041641 TK.Half.Life NA 3.202 hours 1compartment NA NA Rat Human -DTXSID5041641 Css NA 0.767 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041641 Css NA 2.444 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041641 Css NA 0.486 mg/L PBTK NA 50% Rat Human -DTXSID5041641 Css NA 1.405 mg/L PBTK NA 95% Rat Human -DTXSID5041643 Clint NA 2.092 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041643 Fup NA 0.3353 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041643 Vd NA 0.5078 L/kg 1compartment NA NA Human Human +DTXSID5041641 TK.Half.Life NA 0.6595 hours 1compartment NA NA Rat Human +DTXSID5041641 Css NA 0.01833 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041641 Css NA 0.09503 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041641 Css NA 0.01374 mg/L PBTK NA 50% Rat Human +DTXSID5041641 Css NA 0.06172 mg/L PBTK NA 95% Rat Human +DTXSID5041643 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041643 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041643 Vd NA 0.425 L/kg 1compartment NA NA Human Human DTXSID5041643 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041643 TK.Half.Life NA 2.371 hours 1compartment NA NA Human Human -DTXSID5041643 Css NA 0.4927 mg/L 3compartmentss NA 50% Human Human -DTXSID5041643 Css NA 2.592 mg/L 3compartmentss NA 95% Human Human -DTXSID5041643 Css NA 0.3555 mg/L PBTK NA 50% Human Human -DTXSID5041643 Css NA 1.661 mg/L PBTK NA 95% Human Human -DTXSID5041643 Clint NA 2.092 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041643 Fup NA 0.3353 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041643 Vd NA 0.5177 L/kg 1compartment NA NA Rat Human +DTXSID5041643 TK.Half.Life NA 6.809 hours 1compartment NA NA Human Human +DTXSID5041643 Css NA 1.586 mg/L 3compartmentss NA 50% Human Human +DTXSID5041643 Css NA 7.089 mg/L 3compartmentss NA 95% Human Human +DTXSID5041643 Css NA 1.13 mg/L PBTK NA 50% Human Human +DTXSID5041643 Css NA 4.433 mg/L PBTK NA 95% Human Human +DTXSID5041643 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041643 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041643 Vd NA 0.4518 L/kg 1compartment NA NA Rat Human DTXSID5041643 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041643 TK.Half.Life NA 1.311 hours 1compartment NA NA Rat Human -DTXSID5041643 Css NA 0.2235 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041643 Css NA 0.8858 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041643 Css NA 0.1548 mg/L PBTK NA 50% Rat Human -DTXSID5041643 Css NA 0.5268 mg/L PBTK NA 95% Rat Human +DTXSID5041643 TK.Half.Life NA 2.466 hours 1compartment NA NA Rat Human +DTXSID5041643 Css NA 0.02921 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041643 Css NA 0.1795 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041643 Css NA 0.01978 mg/L PBTK NA 50% Rat Human +DTXSID5041643 Css NA 0.1119 mg/L PBTK NA 95% Rat Human DTXSID5041691 Clint 9.846 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5041691 Fup 0.2267 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID5041691 Vd NA 2.571 L/kg 1compartment NA NA Human Human DTXSID5041691 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5041691 TK.Half.Life NA 9.818 hours 1compartment NA NA Human Human -DTXSID5041691 Css NA 0.365 mg/L 3compartmentss NA 50% Human Human -DTXSID5041691 Css NA 2.186 mg/L 3compartmentss NA 95% Human Human -DTXSID5041691 Css NA 0.279 mg/L PBTK NA 50% Human Human -DTXSID5041691 Css NA 1.556 mg/L PBTK NA 95% Human Human +DTXSID5041691 Css NA 0.3525 mg/L 3compartmentss NA 50% Human Human +DTXSID5041691 Css NA 2.093 mg/L 3compartmentss NA 95% Human Human +DTXSID5041691 Css NA 0.2716 mg/L PBTK NA 50% Human Human +DTXSID5041691 Css NA 1.51 mg/L PBTK NA 95% Human Human DTXSID5041691 Clint 9.846 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5041691 Fup 0.2267 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID5041691 Vd NA 2.046 L/kg 1compartment NA NA Rat Human DTXSID5041691 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5041691 TK.Half.Life NA 2.961 hours 1compartment NA NA Rat Human -DTXSID5041691 Css NA 0.193 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041691 Css NA 0.8119 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041691 Css NA 0.1421 mg/L PBTK NA 50% Rat Human -DTXSID5041691 Css NA 0.5603 mg/L PBTK NA 95% Rat Human -DTXSID5041697 Clint NA 81.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041697 Fup NA 0.0779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041697 Vd NA 1.638 L/kg 1compartment NA NA Human Human +DTXSID5041691 Css NA 0.04346 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041691 Css NA 0.1881 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041691 Css NA 0.03323 mg/L PBTK NA 50% Rat Human +DTXSID5041691 Css NA 0.1352 mg/L PBTK NA 95% Rat Human +DTXSID5041697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041697 Fup 0.0988 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041697 Vd NA 1.495 L/kg 1compartment NA NA Human Human DTXSID5041697 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041697 TK.Half.Life NA 2.572 hours 1compartment NA NA Human Human -DTXSID5041697 Css NA 0.1167 mg/L 3compartmentss NA 50% Human Human -DTXSID5041697 Css NA 0.9125 mg/L 3compartmentss NA 95% Human Human -DTXSID5041697 Css NA 0.07651 mg/L PBTK NA 50% Human Human -DTXSID5041697 Css NA 0.5692 mg/L PBTK NA 95% Human Human -DTXSID5041697 Clint NA 81.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041697 Fup NA 0.0779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041697 Vd NA 1.241 L/kg 1compartment NA NA Rat Human +DTXSID5041697 TK.Half.Life NA 4.287 hours 1compartment NA NA Human Human +DTXSID5041697 Css NA 0.3114 mg/L 3compartmentss NA 50% Human Human +DTXSID5041697 Css NA 2.389 mg/L 3compartmentss NA 95% Human Human +DTXSID5041697 Css NA 0.2062 mg/L PBTK NA 50% Human Human +DTXSID5041697 Css NA 1.517 mg/L PBTK NA 95% Human Human +DTXSID5041697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041697 Fup 0.0988 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041697 Vd NA 1.144 L/kg 1compartment NA NA Rat Human DTXSID5041697 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041697 TK.Half.Life NA 0.9227 hours 1compartment NA NA Rat Human -DTXSID5041697 Css NA 0.06596 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041697 Css NA 0.4123 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041697 Css NA 0.04089 mg/L PBTK NA 50% Rat Human -DTXSID5041697 Css NA 0.2458 mg/L PBTK NA 95% Rat Human -DTXSID5041699 Clint NA 23.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041699 Fup NA 0.1148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041699 Vd NA 1.995 L/kg 1compartment NA NA Human Human +DTXSID5041697 TK.Half.Life NA 1.663 hours 1compartment NA NA Rat Human +DTXSID5041697 Css NA 0.03996 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041697 Css NA 0.2367 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041697 Css NA 0.02596 mg/L PBTK NA 50% Rat Human +DTXSID5041697 Css NA 0.1455 mg/L PBTK NA 95% Rat Human +DTXSID5041699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041699 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041699 Vd NA 1.925 L/kg 1compartment NA NA Human Human DTXSID5041699 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041699 TK.Half.Life NA 5.696 hours 1compartment NA NA Human Human -DTXSID5041699 Css NA 0.3078 mg/L 3compartmentss NA 50% Human Human -DTXSID5041699 Css NA 2.064 mg/L 3compartmentss NA 95% Human Human -DTXSID5041699 Css NA 0.2104 mg/L PBTK NA 50% Human Human -DTXSID5041699 Css NA 1.323 mg/L PBTK NA 95% Human Human -DTXSID5041699 Clint NA 23.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041699 Fup NA 0.1148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041699 Vd NA 1.515 L/kg 1compartment NA NA Rat Human +DTXSID5041699 TK.Half.Life NA 6.022 hours 1compartment NA NA Human Human +DTXSID5041699 Css NA 0.3372 mg/L 3compartmentss NA 50% Human Human +DTXSID5041699 Css NA 2.403 mg/L 3compartmentss NA 95% Human Human +DTXSID5041699 Css NA 0.2278 mg/L PBTK NA 50% Human Human +DTXSID5041699 Css NA 1.56 mg/L PBTK NA 95% Human Human +DTXSID5041699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041699 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041699 Vd NA 1.461 L/kg 1compartment NA NA Rat Human DTXSID5041699 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041699 TK.Half.Life NA 1.905 hours 1compartment NA NA Rat Human -DTXSID5041699 Css NA 0.1697 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041699 Css NA 0.8928 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041699 Css NA 0.1097 mg/L PBTK NA 50% Rat Human -DTXSID5041699 Css NA 0.5575 mg/L PBTK NA 95% Rat Human +DTXSID5041699 TK.Half.Life NA 2.057 hours 1compartment NA NA Rat Human +DTXSID5041699 Css NA 0.04327 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041699 Css NA 0.2452 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041699 Css NA 0.02885 mg/L PBTK NA 50% Rat Human +DTXSID5041699 Css NA 0.1547 mg/L PBTK NA 95% Rat Human DTXSID5041726 Clint 1.492 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID5041726 Fup 4.049e-05 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID5041726 Vd NA 0.1698 L/kg 1compartment NA NA Human Human -DTXSID5041726 Days.Css NA 750 Days PBTK NA NA Human Human -DTXSID5041726 TK.Half.Life NA 2746 hours 1compartment NA NA Human Human -DTXSID5041726 Css NA 1800 mg/L 3compartmentss NA 50% Human Human -DTXSID5041726 Css NA 5406 mg/L 3compartmentss NA 95% Human Human -DTXSID5041726 Css NA 1046 mg/L PBTK NA 50% Human Human -DTXSID5041726 Css NA 3124 mg/L PBTK NA 95% Human Human +DTXSID5041726 Vd NA 0.1591 L/kg 1compartment NA NA Human Human +DTXSID5041726 Days.Css NA 798 Days PBTK NA NA Human Human +DTXSID5041726 TK.Half.Life NA 2916 hours 1compartment NA NA Human Human +DTXSID5041726 Css NA 1092 mg/L 3compartmentss NA 50% Human Human +DTXSID5041726 Css NA 3544 mg/L 3compartmentss NA 95% Human Human +DTXSID5041726 Css NA 633 mg/L PBTK NA 50% Human Human +DTXSID5041726 Css NA 2029 mg/L PBTK NA 95% Human Human DTXSID5041726 Clint 1.492 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID5041726 Fup 4.049e-05 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID5041726 Vd NA 0.1629 L/kg 1compartment NA NA Rat Human -DTXSID5041726 Days.Css NA 397 Days PBTK NA NA Rat Human -DTXSID5041726 TK.Half.Life NA 1462 hours 1compartment NA NA Rat Human -DTXSID5041726 Css NA 859 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041726 Css NA 1524 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041726 Css NA 464.1 mg/L PBTK NA 50% Rat Human -DTXSID5041726 Css NA 823.5 mg/L PBTK NA 95% Rat Human -DTXSID5041728 Clint NA 5.527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041728 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041728 Vd NA 0.2325 L/kg 1compartment NA NA Human Human -DTXSID5041728 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5041728 TK.Half.Life NA 18.69 hours 1compartment NA NA Human Human -DTXSID5041728 Css NA 14.83 mg/L 3compartmentss NA 50% Human Human -DTXSID5041728 Css NA 129 mg/L 3compartmentss NA 95% Human Human -DTXSID5041728 Css NA 8.748 mg/L PBTK NA 50% Human Human -DTXSID5041728 Css NA 75.09 mg/L PBTK NA 95% Human Human -DTXSID5041728 Clint NA 5.527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041728 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041728 Vd NA 0.2195 L/kg 1compartment NA NA Rat Human -DTXSID5041728 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5041728 TK.Half.Life NA 11.2 hours 1compartment NA NA Rat Human -DTXSID5041728 Css NA 7.86 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041728 Css NA 53.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041728 Css NA 4.336 mg/L PBTK NA 50% Rat Human -DTXSID5041728 Css NA 28.89 mg/L PBTK NA 95% Rat Human -DTXSID5041772 Clint NA 32.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041772 Fup NA 0.0042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041772 Vd NA 2.992 L/kg 1compartment NA NA Human Human -DTXSID5041772 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID5041772 TK.Half.Life NA 59.45 hours 1compartment NA NA Human Human -DTXSID5041772 Css NA 2.508 mg/L 3compartmentss NA 50% Human Human -DTXSID5041772 Css NA 15.93 mg/L 3compartmentss NA 95% Human Human -DTXSID5041772 Css NA 1.719 mg/L PBTK NA 50% Human Human -DTXSID5041772 Css NA 10.63 mg/L PBTK NA 95% Human Human -DTXSID5041772 Clint NA 32.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041772 Fup NA 0.0042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041772 Vd NA 2.239 L/kg 1compartment NA NA Rat Human -DTXSID5041772 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5041772 TK.Half.Life NA 9.521 hours 1compartment NA NA Rat Human -DTXSID5041772 Css NA 1.414 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041772 Css NA 7.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041772 Css NA 0.9203 mg/L PBTK NA 50% Rat Human -DTXSID5041772 Css NA 4.475 mg/L PBTK NA 95% Rat Human -DTXSID5041774 Clint NA 6.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041774 Fup NA 0.1122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041774 Vd NA 1.64 L/kg 1compartment NA NA Human Human +DTXSID5041726 Vd NA 0.1578 L/kg 1compartment NA NA Rat Human +DTXSID5041726 Days.Css NA 426 Days PBTK NA NA Rat Human +DTXSID5041726 TK.Half.Life NA 1561 hours 1compartment NA NA Rat Human +DTXSID5041726 Css NA 9.43 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041726 Css NA 25.47 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041726 Css NA 5.105 mg/L PBTK NA 50% Rat Human +DTXSID5041726 Css NA 13.8 mg/L PBTK NA 95% Rat Human +DTXSID5041728 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041728 Fup 0.096 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041728 Vd NA 0.229 L/kg 1compartment NA NA Human Human +DTXSID5041728 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5041728 TK.Half.Life NA 1.324 hours 1compartment NA NA Human Human +DTXSID5041728 Css NA 0.4554 mg/L 3compartmentss NA 50% Human Human +DTXSID5041728 Css NA 3.416 mg/L 3compartmentss NA 95% Human Human +DTXSID5041728 Css NA 0.2758 mg/L PBTK NA 50% Human Human +DTXSID5041728 Css NA 2.019 mg/L PBTK NA 95% Human Human +DTXSID5041728 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041728 Fup 0.096 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041728 Vd NA 0.2336 L/kg 1compartment NA NA Rat Human +DTXSID5041728 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5041728 TK.Half.Life NA 0.8282 hours 1compartment NA NA Rat Human +DTXSID5041728 Css NA 0.004665 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041728 Css NA 0.03045 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041728 Css NA 0.002648 mg/L PBTK NA 50% Rat Human +DTXSID5041728 Css NA 0.0168 mg/L PBTK NA 95% Rat Human +DTXSID5041772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041772 Fup 0.0102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041772 Vd NA 3.077 L/kg 1compartment NA NA Human Human +DTXSID5041772 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID5041772 TK.Half.Life NA 85.97 hours 1compartment NA NA Human Human +DTXSID5041772 Css NA 2.97 mg/L 3compartmentss NA 50% Human Human +DTXSID5041772 Css NA 19.93 mg/L 3compartmentss NA 95% Human Human +DTXSID5041772 Css NA 2.047 mg/L PBTK NA 50% Human Human +DTXSID5041772 Css NA 13.19 mg/L PBTK NA 95% Human Human +DTXSID5041772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041772 Fup 0.0102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041772 Vd NA 2.304 L/kg 1compartment NA NA Rat Human +DTXSID5041772 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID5041772 TK.Half.Life NA 12.26 hours 1compartment NA NA Rat Human +DTXSID5041772 Css NA 0.1522 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041772 Css NA 1.033 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041772 Css NA 0.102 mg/L PBTK NA 50% Rat Human +DTXSID5041772 Css NA 0.6625 mg/L PBTK NA 95% Rat Human +DTXSID5041774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041774 Fup 0.0972 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041774 Vd NA 1.514 L/kg 1compartment NA NA Human Human DTXSID5041774 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041774 TK.Half.Life NA 10.82 hours 1compartment NA NA Human Human -DTXSID5041774 Css NA 0.8758 mg/L 3compartmentss NA 50% Human Human -DTXSID5041774 Css NA 5.593 mg/L 3compartmentss NA 95% Human Human -DTXSID5041774 Css NA 0.5894 mg/L PBTK NA 50% Human Human -DTXSID5041774 Css NA 3.543 mg/L PBTK NA 95% Human Human -DTXSID5041774 Clint NA 6.775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041774 Fup NA 0.1122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041774 Vd NA 1.255 L/kg 1compartment NA NA Rat Human +DTXSID5041774 TK.Half.Life NA 4.409 hours 1compartment NA NA Human Human +DTXSID5041774 Css NA 0.319 mg/L 3compartmentss NA 50% Human Human +DTXSID5041774 Css NA 2.436 mg/L 3compartmentss NA 95% Human Human +DTXSID5041774 Css NA 0.2104 mg/L PBTK NA 50% Human Human +DTXSID5041774 Css NA 1.528 mg/L PBTK NA 95% Human Human +DTXSID5041774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041774 Fup 0.0972 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041774 Vd NA 1.157 L/kg 1compartment NA NA Rat Human DTXSID5041774 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041774 TK.Half.Life NA 3.986 hours 1compartment NA NA Rat Human -DTXSID5041774 Css NA 0.4666 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041774 Css NA 2.209 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041774 Css NA 0.2968 mg/L PBTK NA 50% Rat Human -DTXSID5041774 Css NA 1.29 mg/L PBTK NA 95% Rat Human -DTXSID5041778 Clint NA 13.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041778 Fup NA 0.0149 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041778 Vd NA 2.902 L/kg 1compartment NA NA Human Human -DTXSID5041778 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID5041778 TK.Half.Life NA 90.65 hours 1compartment NA NA Human Human -DTXSID5041778 Css NA 4.144 mg/L 3compartmentss NA 50% Human Human -DTXSID5041778 Css NA 27.38 mg/L 3compartmentss NA 95% Human Human -DTXSID5041778 Css NA 2.824 mg/L PBTK NA 50% Human Human -DTXSID5041778 Css NA 17.96 mg/L PBTK NA 95% Human Human -DTXSID5041778 Clint NA 13.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041778 Fup NA 0.0149 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041778 Vd NA 2.171 L/kg 1compartment NA NA Rat Human -DTXSID5041778 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID5041778 TK.Half.Life NA 15.74 hours 1compartment NA NA Rat Human -DTXSID5041778 Css NA 2.367 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041778 Css NA 12.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041778 Css NA 1.528 mg/L PBTK NA 50% Rat Human -DTXSID5041778 Css NA 7.762 mg/L PBTK NA 95% Rat Human -DTXSID5041803 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041803 Fup NA 0.5471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041803 Vd NA 1.448 L/kg 1compartment NA NA Human Human -DTXSID5041803 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5041803 TK.Half.Life NA 20.25 hours 1compartment NA NA Human Human -DTXSID5041803 Css NA 1.435 mg/L 3compartmentss NA 50% Human Human -DTXSID5041803 Css NA 8.781 mg/L 3compartmentss NA 95% Human Human -DTXSID5041803 Css NA 1.226 mg/L PBTK NA 50% Human Human -DTXSID5041803 Css NA 5.816 mg/L PBTK NA 95% Human Human -DTXSID5041803 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041803 Fup NA 0.5471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041803 Vd NA 1.242 L/kg 1compartment NA NA Rat Human -DTXSID5041803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041803 TK.Half.Life NA 5.223 hours 1compartment NA NA Rat Human -DTXSID5041803 Css NA 0.379 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041803 Css NA 2.037 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041803 Css NA 0.3125 mg/L PBTK NA 50% Rat Human -DTXSID5041803 Css NA 1.246 mg/L PBTK NA 95% Rat Human -DTXSID5041809 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041809 Fup NA 0.3287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041809 Vd NA 0.3263 L/kg 1compartment NA NA Human Human +DTXSID5041774 TK.Half.Life NA 1.702 hours 1compartment NA NA Rat Human +DTXSID5041774 Css NA 0.0411 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041774 Css NA 0.2461 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041774 Css NA 0.02677 mg/L PBTK NA 50% Rat Human +DTXSID5041774 Css NA 0.1518 mg/L PBTK NA 95% Rat Human +DTXSID5041778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041778 Fup 0.00782 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041778 Vd NA 2.719 L/kg 1compartment NA NA Human Human +DTXSID5041778 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID5041778 TK.Half.Life NA 58.15 hours 1compartment NA NA Human Human +DTXSID5041778 Css NA 2.903 mg/L 3compartmentss NA 50% Human Human +DTXSID5041778 Css NA 21.02 mg/L 3compartmentss NA 95% Human Human +DTXSID5041778 Css NA 1.932 mg/L PBTK NA 50% Human Human +DTXSID5041778 Css NA 13.56 mg/L PBTK NA 95% Human Human +DTXSID5041778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041778 Fup 0.00782 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041778 Vd NA 2.028 L/kg 1compartment NA NA Rat Human +DTXSID5041778 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID5041778 TK.Half.Life NA 12.05 hours 1compartment NA NA Rat Human +DTXSID5041778 Css NA 0.3797 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041778 Css NA 2.302 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041778 Css NA 0.25 mg/L PBTK NA 50% Rat Human +DTXSID5041778 Css NA 1.434 mg/L PBTK NA 95% Rat Human +DTXSID5041809 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041809 Fup 0.77 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041809 Vd NA 0.5128 L/kg 1compartment NA NA Human Human DTXSID5041809 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5041809 TK.Half.Life NA 6.424 hours 1compartment NA NA Human Human -DTXSID5041809 Css NA 2.46 mg/L 3compartmentss NA 50% Human Human -DTXSID5041809 Css NA 9.421 mg/L 3compartmentss NA 95% Human Human -DTXSID5041809 Css NA 1.628 mg/L PBTK NA 50% Human Human -DTXSID5041809 Css NA 5.723 mg/L PBTK NA 95% Human Human -DTXSID5041809 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041809 Fup NA 0.3287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041809 Vd NA 0.3339 L/kg 1compartment NA NA Rat Human +DTXSID5041809 TK.Half.Life NA 4.308 hours 1compartment NA NA Human Human +DTXSID5041809 Css NA 1.068 mg/L 3compartmentss NA 50% Human Human +DTXSID5041809 Css NA 6.369 mg/L 3compartmentss NA 95% Human Human +DTXSID5041809 Css NA 0.8131 mg/L PBTK NA 50% Human Human +DTXSID5041809 Css NA 3.933 mg/L PBTK NA 95% Human Human +DTXSID5041809 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041809 Fup 0.77 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041809 Vd NA 0.5265 L/kg 1compartment NA NA Rat Human DTXSID5041809 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5041809 TK.Half.Life NA 2.24 hours 1compartment NA NA Rat Human -DTXSID5041809 Css NA 0.6691 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041809 Css NA 2.241 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041809 Css NA 0.4216 mg/L PBTK NA 50% Rat Human -DTXSID5041809 Css NA 1.277 mg/L PBTK NA 95% Rat Human -DTXSID5041851 Clint NA 12.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041851 Fup NA 0.0242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5041851 Vd NA 1.953 L/kg 1compartment NA NA Human Human -DTXSID5041851 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5041851 TK.Half.Life NA 28.28 hours 1compartment NA NA Human Human -DTXSID5041851 Css NA 2.264 mg/L 3compartmentss NA 50% Human Human -DTXSID5041851 Css NA 17.41 mg/L 3compartmentss NA 95% Human Human -DTXSID5041851 Css NA 1.459 mg/L PBTK NA 50% Human Human -DTXSID5041851 Css NA 10.77 mg/L PBTK NA 95% Human Human -DTXSID5041851 Clint NA 12.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041851 Fup NA 0.0242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5041851 Vd NA 1.453 L/kg 1compartment NA NA Rat Human -DTXSID5041851 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5041851 TK.Half.Life NA 9.198 hours 1compartment NA NA Rat Human -DTXSID5041851 Css NA 1.242 mg/L 3compartmentss NA 50% Rat Human -DTXSID5041851 Css NA 7.693 mg/L 3compartmentss NA 95% Rat Human -DTXSID5041851 Css NA 0.7546 mg/L PBTK NA 50% Rat Human -DTXSID5041851 Css NA 4.399 mg/L PBTK NA 95% Rat Human -DTXSID5042083 Clint NA 104.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042083 Fup NA 0.0155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042083 Vd NA 1.976 L/kg 1compartment NA NA Human Human -DTXSID5042083 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5042083 TK.Half.Life NA 6.296 hours 1compartment NA NA Human Human -DTXSID5042083 Css NA 0.3849 mg/L 3compartmentss NA 50% Human Human -DTXSID5042083 Css NA 3.303 mg/L 3compartmentss NA 95% Human Human -DTXSID5042083 Css NA 0.2471 mg/L PBTK NA 50% Human Human -DTXSID5042083 Css NA 2.006 mg/L PBTK NA 95% Human Human -DTXSID5042083 Clint NA 104.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042083 Fup NA 0.0155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042083 Vd NA 1.469 L/kg 1compartment NA NA Rat Human -DTXSID5042083 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5042083 TK.Half.Life NA 2.064 hours 1compartment NA NA Rat Human -DTXSID5042083 Css NA 0.2178 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042083 Css NA 1.578 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042083 Css NA 0.1324 mg/L PBTK NA 50% Rat Human -DTXSID5042083 Css NA 0.9091 mg/L PBTK NA 95% Rat Human -DTXSID5042089 Clint NA 7.605 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042089 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042089 Vd NA 2.847 L/kg 1compartment NA NA Human Human -DTXSID5042089 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID5042089 TK.Half.Life NA 93.88 hours 1compartment NA NA Human Human -DTXSID5042089 Css NA 4.428 mg/L 3compartmentss NA 50% Human Human -DTXSID5042089 Css NA 26.02 mg/L 3compartmentss NA 95% Human Human -DTXSID5042089 Css NA 3.018 mg/L PBTK NA 50% Human Human -DTXSID5042089 Css NA 17.11 mg/L PBTK NA 95% Human Human -DTXSID5042089 Clint NA 7.605 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042089 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042089 Vd NA 2.132 L/kg 1compartment NA NA Rat Human -DTXSID5042089 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID5042089 TK.Half.Life NA 17.07 hours 1compartment NA NA Rat Human -DTXSID5042089 Css NA 2.42 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042089 Css NA 11.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042089 Css NA 1.57 mg/L PBTK NA 50% Rat Human -DTXSID5042089 Css NA 7.099 mg/L PBTK NA 95% Rat Human +DTXSID5041809 TK.Half.Life NA 1.507 hours 1compartment NA NA Rat Human +DTXSID5041809 Css NA 0.0633 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041809 Css NA 0.378 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041809 Css NA 0.04803 mg/L PBTK NA 50% Rat Human +DTXSID5041809 Css NA 0.2274 mg/L PBTK NA 95% Rat Human +DTXSID5041851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041851 Fup 0.04 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5041851 Vd NA 2.272 L/kg 1compartment NA NA Human Human +DTXSID5041851 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5041851 TK.Half.Life NA 16.26 hours 1compartment NA NA Human Human +DTXSID5041851 Css NA 0.9624 mg/L 3compartmentss NA 50% Human Human +DTXSID5041851 Css NA 7.476 mg/L 3compartmentss NA 95% Human Human +DTXSID5041851 Css NA 0.6368 mg/L PBTK NA 50% Human Human +DTXSID5041851 Css NA 4.775 mg/L PBTK NA 95% Human Human +DTXSID5041851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041851 Fup 0.04 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5041851 Vd NA 1.699 L/kg 1compartment NA NA Rat Human +DTXSID5041851 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5041851 TK.Half.Life NA 4.661 hours 1compartment NA NA Rat Human +DTXSID5041851 Css NA 0.1255 mg/L 3compartmentss NA 50% Rat Human +DTXSID5041851 Css NA 0.7664 mg/L 3compartmentss NA 95% Rat Human +DTXSID5041851 Css NA 0.08121 mg/L PBTK NA 50% Rat Human +DTXSID5041851 Css NA 0.4754 mg/L PBTK NA 95% Rat Human +DTXSID5042035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042035 Fup 0.0229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042035 Vd NA 4.686 L/kg 1compartment NA NA Human Human +DTXSID5042035 Days.Css NA 25 Days PBTK NA NA Human Human +DTXSID5042035 TK.Half.Life NA 140.7 hours 1compartment NA NA Human Human +DTXSID5042035 Css NA 1.65 mg/L 3compartmentss NA 50% Human Human +DTXSID5042035 Css NA 10.4 mg/L 3compartmentss NA 95% Human Human +DTXSID5042035 Css NA 1.304 mg/L PBTK NA 50% Human Human +DTXSID5042035 Css NA 8.014 mg/L PBTK NA 95% Human Human +DTXSID5042035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042035 Fup 0.0229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042035 Vd NA 3.568 L/kg 1compartment NA NA Rat Human +DTXSID5042035 Days.Css NA 15 Days PBTK NA NA Rat Human +DTXSID5042035 TK.Half.Life NA 18.94 hours 1compartment NA NA Rat Human +DTXSID5042035 Css NA 0.0176 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042035 Css NA 0.1087 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042035 Css NA 0.01357 mg/L PBTK NA 50% Rat Human +DTXSID5042035 Css NA 0.08301 mg/L PBTK NA 95% Rat Human +DTXSID5042039 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042039 Fup 0.0177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042039 Vd NA 16.4 L/kg 1compartment NA NA Human Human +DTXSID5042039 Days.Css NA 109 Days PBTK NA NA Human Human +DTXSID5042039 TK.Half.Life NA 486.8 hours 1compartment NA NA Human Human +DTXSID5042039 Css NA 0.7326 mg/L 3compartmentss NA 50% Human Human +DTXSID5042039 Css NA 4.791 mg/L 3compartmentss NA 95% Human Human +DTXSID5042039 Css NA 1.301 mg/L PBTK NA 50% Human Human +DTXSID5042039 Css NA 8.062 mg/L PBTK NA 95% Human Human +DTXSID5042039 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042039 Fup 0.0177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042039 Vd NA 13.2 L/kg 1compartment NA NA Rat Human +DTXSID5042039 Days.Css NA 66 Days PBTK NA NA Rat Human +DTXSID5042039 TK.Half.Life NA 68.16 hours 1compartment NA NA Rat Human +DTXSID5042039 Css NA 0.007515 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042039 Css NA 0.04423 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042039 Css NA 0.01366 mg/L PBTK NA 50% Rat Human +DTXSID5042039 Css NA 0.0796 mg/L PBTK NA 95% Rat Human +DTXSID5042083 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042083 Fup 0.0143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042083 Vd NA 1.894 L/kg 1compartment NA NA Human Human +DTXSID5042083 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5042083 TK.Half.Life NA 23.41 hours 1compartment NA NA Human Human +DTXSID5042083 Css NA 1.853 mg/L 3compartmentss NA 50% Human Human +DTXSID5042083 Css NA 16.04 mg/L 3compartmentss NA 95% Human Human +DTXSID5042083 Css NA 1.186 mg/L PBTK NA 50% Human Human +DTXSID5042083 Css NA 9.566 mg/L PBTK NA 95% Human Human +DTXSID5042083 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042083 Fup 0.0143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042083 Vd NA 1.407 L/kg 1compartment NA NA Rat Human +DTXSID5042083 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5042083 TK.Half.Life NA 7.859 hours 1compartment NA NA Rat Human +DTXSID5042083 Css NA 0.2432 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042083 Css NA 1.672 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042083 Css NA 0.1522 mg/L PBTK NA 50% Rat Human +DTXSID5042083 Css NA 0.9934 mg/L PBTK NA 95% Rat Human +DTXSID5042089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042089 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042089 Vd NA 2.735 L/kg 1compartment NA NA Human Human +DTXSID5042089 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5042089 TK.Half.Life NA 35.17 hours 1compartment NA NA Human Human +DTXSID5042089 Css NA 1.675 mg/L 3compartmentss NA 50% Human Human +DTXSID5042089 Css NA 11.44 mg/L 3compartmentss NA 95% Human Human +DTXSID5042089 Css NA 1.125 mg/L PBTK NA 50% Human Human +DTXSID5042089 Css NA 7.409 mg/L PBTK NA 95% Human Human +DTXSID5042089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042089 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042089 Vd NA 2.046 L/kg 1compartment NA NA Rat Human +DTXSID5042089 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5042089 TK.Half.Life NA 7.348 hours 1compartment NA NA Rat Human +DTXSID5042089 Css NA 0.218 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042089 Css NA 1.271 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042089 Css NA 0.1442 mg/L PBTK NA 50% Rat Human +DTXSID5042089 Css NA 0.8156 mg/L PBTK NA 95% Rat Human DTXSID5042243 Clint 41.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5042243 Fup 3.54e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5042243 Vd NA 0.2235 L/kg 1compartment NA NA Human Human -DTXSID5042243 Days.Css NA 28 Days PBTK NA NA Human Human -DTXSID5042243 TK.Half.Life NA 126.4 hours 1compartment NA NA Human Human -DTXSID5042243 Css NA 37.64 mg/L 3compartmentss NA 50% Human Human -DTXSID5042243 Css NA 244.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5042243 Css NA 22.1 mg/L PBTK NA 50% Human Human -DTXSID5042243 Css NA 140.1 mg/L PBTK NA 95% Human Human +DTXSID5042243 Vd NA 0.1892 L/kg 1compartment NA NA Human Human +DTXSID5042243 Days.Css NA 27 Days PBTK NA NA Human Human +DTXSID5042243 TK.Half.Life NA 122.6 hours 1compartment NA NA Human Human +DTXSID5042243 Css NA 17.02 mg/L 3compartmentss NA 50% Human Human +DTXSID5042243 Css NA 130.5 mg/L 3compartmentss NA 95% Human Human +DTXSID5042243 Css NA 9.971 mg/L PBTK NA 50% Human Human +DTXSID5042243 Css NA 75.52 mg/L PBTK NA 95% Human Human DTXSID5042243 Clint 41.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5042243 Fup 3.54e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5042243 Vd NA 0.1923 L/kg 1compartment NA NA Rat Human -DTXSID5042243 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID5042243 TK.Half.Life NA 75.65 hours 1compartment NA NA Rat Human -DTXSID5042243 Css NA 28.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042243 Css NA 90.51 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042243 Css NA 15.33 mg/L PBTK NA 50% Rat Human -DTXSID5042243 Css NA 49.02 mg/L PBTK NA 95% Rat Human -DTXSID5042249 Clint NA 1.843 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042249 Fup NA 0.4123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042249 Vd NA 3.093 L/kg 1compartment NA NA Human Human -DTXSID5042249 Days.Css NA 32 Days PBTK NA NA Human Human -DTXSID5042249 TK.Half.Life NA 165.9 hours 1compartment NA NA Human Human -DTXSID5042249 Css NA 6.313 mg/L 3compartmentss NA 50% Human Human -DTXSID5042249 Css NA 26.14 mg/L 3compartmentss NA 95% Human Human -DTXSID5042249 Css NA 4.518 mg/L PBTK NA 50% Human Human -DTXSID5042249 Css NA 17.68 mg/L PBTK NA 95% Human Human -DTXSID5042249 Clint NA 1.843 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042249 Fup NA 0.4123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042249 Vd NA 2.333 L/kg 1compartment NA NA Rat Human -DTXSID5042249 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID5042249 TK.Half.Life NA 20.87 hours 1compartment NA NA Rat Human -DTXSID5042249 Css NA 3.03 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042249 Css NA 8.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042249 Css NA 2.09 mg/L PBTK NA 50% Rat Human -DTXSID5042249 Css NA 5.766 mg/L PBTK NA 95% Rat Human -DTXSID5042297 Clint NA 414.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042297 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042297 Vd NA 2.932 L/kg 1compartment NA NA Human Human -DTXSID5042297 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5042297 TK.Half.Life NA 5.247 hours 1compartment NA NA Human Human -DTXSID5042297 Css NA 0.13 mg/L 3compartmentss NA 50% Human Human -DTXSID5042297 Css NA 0.9161 mg/L 3compartmentss NA 95% Human Human -DTXSID5042297 Css NA 0.08854 mg/L PBTK NA 50% Human Human -DTXSID5042297 Css NA 0.6113 mg/L PBTK NA 95% Human Human -DTXSID5042297 Clint NA 414.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042297 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042297 Vd NA 2.193 L/kg 1compartment NA NA Rat Human -DTXSID5042297 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5042297 TK.Half.Life NA 1.261 hours 1compartment NA NA Rat Human -DTXSID5042297 Css NA 0.07357 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042297 Css NA 0.4261 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042297 Css NA 0.04774 mg/L PBTK NA 50% Rat Human -DTXSID5042297 Css NA 0.2669 mg/L PBTK NA 95% Rat Human -DTXSID5042299 Clint NA 8.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042299 Fup NA 0.2092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042299 Vd NA 2.266 L/kg 1compartment NA NA Human Human +DTXSID5042243 Vd NA 0.1732 L/kg 1compartment NA NA Rat Human +DTXSID5042243 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID5042243 TK.Half.Life NA 77.96 hours 1compartment NA NA Rat Human +DTXSID5042243 Css NA 0.2012 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042243 Css NA 0.8849 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042243 Css NA 0.109 mg/L PBTK NA 50% Rat Human +DTXSID5042243 Css NA 0.4798 mg/L PBTK NA 95% Rat Human +DTXSID5042297 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042297 Fup 0.0398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042297 Vd NA 3.049 L/kg 1compartment NA NA Human Human +DTXSID5042297 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID5042297 TK.Half.Life NA 55.1 hours 1compartment NA NA Human Human +DTXSID5042297 Css NA 2.18 mg/L 3compartmentss NA 50% Human Human +DTXSID5042297 Css NA 14.58 mg/L 3compartmentss NA 95% Human Human +DTXSID5042297 Css NA 1.497 mg/L PBTK NA 50% Human Human +DTXSID5042297 Css NA 9.724 mg/L PBTK NA 95% Human Human +DTXSID5042297 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042297 Fup 0.0398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042297 Vd NA 2.285 L/kg 1compartment NA NA Rat Human +DTXSID5042297 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID5042297 TK.Half.Life NA 8.349 hours 1compartment NA NA Rat Human +DTXSID5042297 Css NA 0.2819 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042297 Css NA 1.658 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042297 Css NA 0.193 mg/L PBTK NA 50% Rat Human +DTXSID5042297 Css NA 1.092 mg/L PBTK NA 95% Rat Human +DTXSID5042299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042299 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042299 Vd NA 1.818 L/kg 1compartment NA NA Human Human DTXSID5042299 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5042299 TK.Half.Life NA 10.32 hours 1compartment NA NA Human Human -DTXSID5042299 Css NA 0.4722 mg/L 3compartmentss NA 50% Human Human -DTXSID5042299 Css NA 2.65 mg/L 3compartmentss NA 95% Human Human -DTXSID5042299 Css NA 0.3431 mg/L PBTK NA 50% Human Human -DTXSID5042299 Css NA 1.823 mg/L PBTK NA 95% Human Human -DTXSID5042299 Clint NA 8.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042299 Fup NA 0.2092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042299 Vd NA 1.737 L/kg 1compartment NA NA Rat Human +DTXSID5042299 TK.Half.Life NA 5.271 hours 1compartment NA NA Human Human +DTXSID5042299 Css NA 0.3034 mg/L 3compartmentss NA 50% Human Human +DTXSID5042299 Css NA 2.197 mg/L 3compartmentss NA 95% Human Human +DTXSID5042299 Css NA 0.2054 mg/L PBTK NA 50% Human Human +DTXSID5042299 Css NA 1.419 mg/L PBTK NA 95% Human Human +DTXSID5042299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042299 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042299 Vd NA 1.384 L/kg 1compartment NA NA Rat Human DTXSID5042299 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5042299 TK.Half.Life NA 3.058 hours 1compartment NA NA Rat Human -DTXSID5042299 Css NA 0.245 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042299 Css NA 1.001 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042299 Css NA 0.1713 mg/L PBTK NA 50% Rat Human -DTXSID5042299 Css NA 0.6493 mg/L PBTK NA 95% Rat Human -DTXSID5042320 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042320 Fup NA 0.2751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042320 Vd NA 0.3843 L/kg 1compartment NA NA Human Human -DTXSID5042320 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5042320 TK.Half.Life NA 9.039 hours 1compartment NA NA Human Human -DTXSID5042320 Css NA 2.842 mg/L 3compartmentss NA 50% Human Human -DTXSID5042320 Css NA 10.97 mg/L 3compartmentss NA 95% Human Human -DTXSID5042320 Css NA 1.918 mg/L PBTK NA 50% Human Human -DTXSID5042320 Css NA 6.707 mg/L PBTK NA 95% Human Human -DTXSID5042320 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042320 Fup NA 0.2751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042320 Vd NA 0.3959 L/kg 1compartment NA NA Rat Human -DTXSID5042320 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5042320 TK.Half.Life NA 3.172 hours 1compartment NA NA Rat Human -DTXSID5042320 Css NA 0.7834 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042320 Css NA 2.561 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042320 Css NA 0.5034 mg/L PBTK NA 50% Rat Human -DTXSID5042320 Css NA 1.472 mg/L PBTK NA 95% Rat Human -DTXSID5042322 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042322 Fup NA 0.0164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042322 Vd NA 2.365 L/kg 1compartment NA NA Human Human -DTXSID5042322 Days.Css NA 637 Days PBTK NA NA Human Human -DTXSID5042322 TK.Half.Life NA 2407 hours 1compartment NA NA Human Human -DTXSID5042322 Css NA 140.6 mg/L 3compartmentss NA 50% Human Human -DTXSID5042322 Css NA 568 mg/L 3compartmentss NA 95% Human Human -DTXSID5042322 Css NA 93.84 mg/L PBTK NA 50% Human Human -DTXSID5042322 Css NA 347.5 mg/L PBTK NA 95% Human Human -DTXSID5042322 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042322 Fup NA 0.0164 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042322 Vd NA 1.766 L/kg 1compartment NA NA Rat Human -DTXSID5042322 Days.Css NA 160 Days PBTK NA NA Rat Human -DTXSID5042322 TK.Half.Life NA 327 hours 1compartment NA NA Rat Human -DTXSID5042322 Css NA 38.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042322 Css NA 132.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042322 Css NA 24.35 mg/L PBTK NA 50% Rat Human -DTXSID5042322 Css NA 75.43 mg/L PBTK NA 95% Rat Human -DTXSID5042324 Clint NA 1.698 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042324 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042324 Vd NA 0.1799 L/kg 1compartment NA NA Human Human -DTXSID5042324 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID5042324 TK.Half.Life NA 35.88 hours 1compartment NA NA Human Human -DTXSID5042324 Css NA 35.97 mg/L 3compartmentss NA 50% Human Human -DTXSID5042324 Css NA 257.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5042324 Css NA 20.94 mg/L PBTK NA 50% Human Human -DTXSID5042324 Css NA 150.3 mg/L PBTK NA 95% Human Human -DTXSID5042324 Clint NA 1.698 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042324 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042324 Vd NA 0.1756 L/kg 1compartment NA NA Rat Human -DTXSID5042324 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5042324 TK.Half.Life NA 19.23 hours 1compartment NA NA Rat Human -DTXSID5042324 Css NA 16.48 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042324 Css NA 100.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042324 Css NA 8.968 mg/L PBTK NA 50% Rat Human -DTXSID5042324 Css NA 54.53 mg/L PBTK NA 95% Rat Human -DTXSID5042459 Clint NA 148.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042459 Fup NA 0.4582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042459 Vd NA 19.97 L/kg 1compartment NA NA Human Human -DTXSID5042459 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID5042459 TK.Half.Life NA 89.94 hours 1compartment NA NA Human Human -DTXSID5042459 Css NA 0.1645 mg/L 3compartmentss NA 50% Human Human -DTXSID5042459 Css NA 0.9699 mg/L 3compartmentss NA 95% Human Human -DTXSID5042459 Css NA 0.3508 mg/L PBTK NA 50% Human Human -DTXSID5042459 Css NA 1.957 mg/L PBTK NA 95% Human Human -DTXSID5042459 Clint NA 148.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042459 Fup NA 0.4582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042459 Vd NA 16.21 L/kg 1compartment NA NA Rat Human -DTXSID5042459 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID5042459 TK.Half.Life NA 13.35 hours 1compartment NA NA Rat Human -DTXSID5042459 Css NA 0.08756 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042459 Css NA 0.3806 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042459 Css NA 0.1908 mg/L PBTK NA 50% Rat Human -DTXSID5042459 Css NA 0.839 mg/L PBTK NA 95% Rat Human -DTXSID5042584 Clint NA 28.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042584 Fup NA 0.0442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042584 Vd NA 1.051 L/kg 1compartment NA NA Human Human +DTXSID5042299 TK.Half.Life NA 1.867 hours 1compartment NA NA Rat Human +DTXSID5042299 Css NA 0.03928 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042299 Css NA 0.2249 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042299 Css NA 0.02614 mg/L PBTK NA 50% Rat Human +DTXSID5042299 Css NA 0.1418 mg/L PBTK NA 95% Rat Human +DTXSID5042322 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042322 Fup 0.0593 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042322 Vd NA 0.7162 L/kg 1compartment NA NA Human Human +DTXSID5042322 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5042322 TK.Half.Life NA 2.663 hours 1compartment NA NA Human Human +DTXSID5042322 Css NA 0.481 mg/L 3compartmentss NA 50% Human Human +DTXSID5042322 Css NA 3.941 mg/L 3compartmentss NA 95% Human Human +DTXSID5042322 Css NA 0.3078 mg/L PBTK NA 50% Human Human +DTXSID5042322 Css NA 2.376 mg/L PBTK NA 95% Human Human +DTXSID5042322 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042322 Fup 0.0593 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042322 Vd NA 0.5777 L/kg 1compartment NA NA Rat Human +DTXSID5042322 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5042322 TK.Half.Life NA 1.284 hours 1compartment NA NA Rat Human +DTXSID5042322 Css NA 0.062 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042322 Css NA 0.4085 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042322 Css NA 0.03865 mg/L PBTK NA 50% Rat Human +DTXSID5042322 Css NA 0.2391 mg/L PBTK NA 95% Rat Human +DTXSID5042324 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042324 Fup 0.0541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042324 Vd NA 0.4266 L/kg 1compartment NA NA Human Human +DTXSID5042324 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5042324 TK.Half.Life NA 4.718 hours 1compartment NA NA Human Human +DTXSID5042324 Css NA 1.804 mg/L 3compartmentss NA 50% Human Human +DTXSID5042324 Css NA 12.5 mg/L 3compartmentss NA 95% Human Human +DTXSID5042324 Css NA 1.096 mg/L PBTK NA 50% Human Human +DTXSID5042324 Css NA 7.326 mg/L PBTK NA 95% Human Human +DTXSID5042324 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042324 Fup 0.0541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042324 Vd NA 0.3559 L/kg 1compartment NA NA Rat Human +DTXSID5042324 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5042324 TK.Half.Life NA 2.424 hours 1compartment NA NA Rat Human +DTXSID5042324 Css NA 0.2213 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042324 Css NA 1.166 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042324 Css NA 0.1297 mg/L PBTK NA 50% Rat Human +DTXSID5042324 Css NA 0.6606 mg/L PBTK NA 95% Rat Human +DTXSID5042584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042584 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042584 Vd NA 1.574 L/kg 1compartment NA NA Human Human DTXSID5042584 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5042584 TK.Half.Life NA 3.584 hours 1compartment NA NA Human Human -DTXSID5042584 Css NA 0.4377 mg/L 3compartmentss NA 50% Human Human -DTXSID5042584 Css NA 4.031 mg/L 3compartmentss NA 95% Human Human -DTXSID5042584 Css NA 0.2898 mg/L PBTK NA 50% Human Human -DTXSID5042584 Css NA 2.488 mg/L PBTK NA 95% Human Human -DTXSID5042584 Clint NA 28.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042584 Fup NA 0.0442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042584 Vd NA 0.9931 L/kg 1compartment NA NA Rat Human +DTXSID5042584 TK.Half.Life NA 2.607 hours 1compartment NA NA Human Human +DTXSID5042584 Css NA 0.1044 mg/L 3compartmentss NA 50% Human Human +DTXSID5042584 Css NA 0.8238 mg/L 3compartmentss NA 95% Human Human +DTXSID5042584 Css NA 0.0821 mg/L PBTK NA 50% Human Human +DTXSID5042584 Css NA 0.5976 mg/L PBTK NA 95% Human Human +DTXSID5042584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042584 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042584 Vd NA 1.563 L/kg 1compartment NA NA Rat Human DTXSID5042584 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5042584 TK.Half.Life NA 2.081 hours 1compartment NA NA Rat Human -DTXSID5042584 Css NA 0.2489 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042584 Css NA 1.766 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042584 Css NA 0.1536 mg/L PBTK NA 50% Rat Human -DTXSID5042584 Css NA 1.025 mg/L PBTK NA 95% Rat Human -DTXSID5042613 Clint NA 18.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042613 Fup NA 0.5038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5042613 Vd NA 2.137 L/kg 1compartment NA NA Human Human +DTXSID5042584 TK.Half.Life NA 1.481 hours 1compartment NA NA Rat Human +DTXSID5042584 Css NA 0.01311 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042584 Css NA 0.07434 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042584 Css NA 0.01047 mg/L PBTK NA 50% Rat Human +DTXSID5042584 Css NA 0.0535 mg/L PBTK NA 95% Rat Human +DTXSID5042613 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042613 Fup 0.742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5042613 Vd NA 2.808 L/kg 1compartment NA NA Human Human DTXSID5042613 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5042613 TK.Half.Life NA 1.888 hours 1compartment NA NA Human Human -DTXSID5042613 Css NA 0.03709 mg/L 3compartmentss NA 50% Human Human -DTXSID5042613 Css NA 0.3574 mg/L 3compartmentss NA 95% Human Human -DTXSID5042613 Css NA 0.03738 mg/L PBTK NA 50% Human Human -DTXSID5042613 Css NA 0.2882 mg/L PBTK NA 95% Human Human -DTXSID5042613 Clint NA 18.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042613 Fup NA 0.5038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5042613 Vd NA 2.138 L/kg 1compartment NA NA Rat Human +DTXSID5042613 TK.Half.Life NA 3.093 hours 1compartment NA NA Human Human +DTXSID5042613 Css NA 0.05666 mg/L 3compartmentss NA 50% Human Human +DTXSID5042613 Css NA 0.562 mg/L 3compartmentss NA 95% Human Human +DTXSID5042613 Css NA 0.06558 mg/L PBTK NA 50% Human Human +DTXSID5042613 Css NA 0.4688 mg/L PBTK NA 95% Human Human +DTXSID5042613 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042613 Fup 0.742 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5042613 Vd NA 2.823 L/kg 1compartment NA NA Rat Human DTXSID5042613 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5042613 TK.Half.Life NA 1.005 hours 1compartment NA NA Rat Human -DTXSID5042613 Css NA 0.01913 mg/L 3compartmentss NA 50% Rat Human -DTXSID5042613 Css NA 0.1513 mg/L 3compartmentss NA 95% Rat Human -DTXSID5042613 Css NA 0.01932 mg/L PBTK NA 50% Rat Human -DTXSID5042613 Css NA 0.1116 mg/L PBTK NA 95% Rat Human -DTXSID5043714 Clint NA 0.1485 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5043714 Fup NA 0.8997 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5043714 Vd NA 0.5064 L/kg 1compartment NA NA Human Human +DTXSID5042613 TK.Half.Life NA 1.727 hours 1compartment NA NA Rat Human +DTXSID5042613 Css NA 0.002477 mg/L 3compartmentss NA 50% Rat Human +DTXSID5042613 Css NA 0.03129 mg/L 3compartmentss NA 95% Rat Human +DTXSID5042613 Css NA 0.002946 mg/L PBTK NA 50% Rat Human +DTXSID5042613 Css NA 0.02495 mg/L PBTK NA 95% Rat Human +DTXSID5043714 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5043714 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5043714 Vd NA 0.3871 L/kg 1compartment NA NA Human Human DTXSID5043714 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5043714 TK.Half.Life NA 2.932 hours 1compartment NA NA Human Human -DTXSID5043714 Css NA 0.7754 mg/L 3compartmentss NA 50% Human Human -DTXSID5043714 Css NA 2.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5043714 Css NA 0.58 mg/L PBTK NA 50% Human Human -DTXSID5043714 Css NA 1.833 mg/L PBTK NA 95% Human Human -DTXSID5043714 Clint NA 0.1485 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5043714 Fup NA 0.8997 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5043714 Vd NA 0.5281 L/kg 1compartment NA NA Rat Human +DTXSID5043714 TK.Half.Life NA 3.603 hours 1compartment NA NA Human Human +DTXSID5043714 Css NA 1.072 mg/L 3compartmentss NA 50% Human Human +DTXSID5043714 Css NA 6.61 mg/L 3compartmentss NA 95% Human Human +DTXSID5043714 Css NA 0.7627 mg/L PBTK NA 50% Human Human +DTXSID5043714 Css NA 4.083 mg/L PBTK NA 95% Human Human +DTXSID5043714 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5043714 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5043714 Vd NA 0.4136 L/kg 1compartment NA NA Rat Human DTXSID5043714 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5043714 TK.Half.Life NA 1.157 hours 1compartment NA NA Rat Human -DTXSID5043714 Css NA 0.2248 mg/L 3compartmentss NA 50% Rat Human -DTXSID5043714 Css NA 0.791 mg/L 3compartmentss NA 95% Rat Human -DTXSID5043714 Css NA 0.1635 mg/L PBTK NA 50% Rat Human -DTXSID5043714 Css NA 0.4778 mg/L PBTK NA 95% Rat Human -DTXSID5043895 Clint NA 34.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5043895 Fup NA 0.0354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5043895 Vd NA 2.157 L/kg 1compartment NA NA Human Human -DTXSID5043895 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5043895 TK.Half.Life NA 10.38 hours 1compartment NA NA Human Human -DTXSID5043895 Css NA 0.6268 mg/L 3compartmentss NA 50% Human Human -DTXSID5043895 Css NA 4.404 mg/L 3compartmentss NA 95% Human Human -DTXSID5043895 Css NA 0.4117 mg/L PBTK NA 50% Human Human -DTXSID5043895 Css NA 2.802 mg/L PBTK NA 95% Human Human -DTXSID5043895 Clint NA 34.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5043895 Fup NA 0.0354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5043895 Vd NA 1.642 L/kg 1compartment NA NA Rat Human -DTXSID5043895 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5043895 TK.Half.Life NA 3.362 hours 1compartment NA NA Rat Human -DTXSID5043895 Css NA 0.3469 mg/L 3compartmentss NA 50% Rat Human -DTXSID5043895 Css NA 1.909 mg/L 3compartmentss NA 95% Rat Human -DTXSID5043895 Css NA 0.2175 mg/L PBTK NA 50% Rat Human -DTXSID5043895 Css NA 1.141 mg/L PBTK NA 95% Rat Human -DTXSID5043897 Clint NA 10.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5043897 Fup NA 0.0688 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5043897 Vd NA 2.569 L/kg 1compartment NA NA Human Human +DTXSID5043714 TK.Half.Life NA 1.312 hours 1compartment NA NA Rat Human +DTXSID5043714 Css NA 0.02828 mg/L 3compartmentss NA 50% Rat Human +DTXSID5043714 Css NA 0.1974 mg/L 3compartmentss NA 95% Rat Human +DTXSID5043714 Css NA 0.01944 mg/L PBTK NA 50% Rat Human +DTXSID5043714 Css NA 0.117 mg/L PBTK NA 95% Rat Human +DTXSID5043895 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5043895 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5043895 Vd NA 2.871 L/kg 1compartment NA NA Human Human +DTXSID5043895 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5043895 TK.Half.Life NA 41.43 hours 1compartment NA NA Human Human +DTXSID5043895 Css NA 1.722 mg/L 3compartmentss NA 50% Human Human +DTXSID5043895 Css NA 10.19 mg/L 3compartmentss NA 95% Human Human +DTXSID5043895 Css NA 1.229 mg/L PBTK NA 50% Human Human +DTXSID5043895 Css NA 6.863 mg/L PBTK NA 95% Human Human +DTXSID5043895 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5043895 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5043895 Vd NA 2.206 L/kg 1compartment NA NA Rat Human +DTXSID5043895 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5043895 TK.Half.Life NA 8.6 hours 1compartment NA NA Rat Human +DTXSID5043895 Css NA 0.2112 mg/L 3compartmentss NA 50% Rat Human +DTXSID5043895 Css NA 0.8771 mg/L 3compartmentss NA 95% Rat Human +DTXSID5043895 Css NA 0.1499 mg/L PBTK NA 50% Rat Human +DTXSID5043895 Css NA 0.5936 mg/L PBTK NA 95% Rat Human +DTXSID5043897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5043897 Fup 0.0485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5043897 Vd NA 2.282 L/kg 1compartment NA NA Human Human DTXSID5043897 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5043897 TK.Half.Life NA 8.202 hours 1compartment NA NA Human Human -DTXSID5043897 Css NA 0.3454 mg/L 3compartmentss NA 50% Human Human -DTXSID5043897 Css NA 2.855 mg/L 3compartmentss NA 95% Human Human -DTXSID5043897 Css NA 0.2852 mg/L PBTK NA 50% Human Human -DTXSID5043897 Css NA 2.036 mg/L PBTK NA 95% Human Human -DTXSID5043897 Clint NA 10.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5043897 Fup NA 0.0688 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5043897 Vd NA 2.456 L/kg 1compartment NA NA Rat Human +DTXSID5043897 TK.Half.Life NA 5.212 hours 1compartment NA NA Human Human +DTXSID5043897 Css NA 0.22 mg/L 3compartmentss NA 50% Human Human +DTXSID5043897 Css NA 2.167 mg/L 3compartmentss NA 95% Human Human +DTXSID5043897 Css NA 0.1707 mg/L PBTK NA 50% Human Human +DTXSID5043897 Css NA 1.46 mg/L PBTK NA 95% Human Human +DTXSID5043897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5043897 Fup 0.0485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5043897 Vd NA 2.142 L/kg 1compartment NA NA Rat Human DTXSID5043897 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5043897 TK.Half.Life NA 4.524 hours 1compartment NA NA Rat Human -DTXSID5043897 Css NA 0.1888 mg/L 3compartmentss NA 50% Rat Human -DTXSID5043897 Css NA 1.178 mg/L 3compartmentss NA 95% Rat Human -DTXSID5043897 Css NA 0.1503 mg/L PBTK NA 50% Rat Human -DTXSID5043897 Css NA 0.7959 mg/L PBTK NA 95% Rat Human -DTXSID5044023 Clint NA 182 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044023 Fup NA 0.0094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044023 Vd NA 47.85 L/kg 1compartment NA NA Human Human +DTXSID5043897 TK.Half.Life NA 2.759 hours 1compartment NA NA Rat Human +DTXSID5043897 Css NA 0.02894 mg/L 3compartmentss NA 50% Rat Human +DTXSID5043897 Css NA 0.2217 mg/L 3compartmentss NA 95% Rat Human +DTXSID5043897 Css NA 0.02215 mg/L PBTK NA 50% Rat Human +DTXSID5043897 Css NA 0.1464 mg/L PBTK NA 95% Rat Human +DTXSID5044023 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044023 Fup 0.0288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044023 Vd NA 9.847 L/kg 1compartment NA NA Human Human DTXSID5044023 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044023 TK.Half.Life NA 9.319 hours 1compartment NA NA Human Human -DTXSID5044023 Css NA 0.002294 mg/L 3compartmentss NA 50% Human Human -DTXSID5044023 Css NA 0.03752 mg/L 3compartmentss NA 95% Human Human -DTXSID5044023 Css NA 0.01054 mg/L PBTK NA 50% Human Human -DTXSID5044023 Css NA 0.08957 mg/L PBTK NA 95% Human Human -DTXSID5044023 Clint NA 182 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044023 Fup NA 0.0094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044023 Vd NA 40.46 L/kg 1compartment NA NA Rat Human +DTXSID5044023 TK.Half.Life NA 9.377 hours 1compartment NA NA Human Human +DTXSID5044023 Css NA 0.0405 mg/L 3compartmentss NA 50% Human Human +DTXSID5044023 Css NA 0.3876 mg/L 3compartmentss NA 95% Human Human +DTXSID5044023 Css NA 0.04992 mg/L PBTK NA 50% Human Human +DTXSID5044023 Css NA 0.3799 mg/L PBTK NA 95% Human Human +DTXSID5044023 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044023 Fup 0.0288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044023 Vd NA 7.987 L/kg 1compartment NA NA Rat Human DTXSID5044023 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044023 TK.Half.Life NA 3.474 hours 1compartment NA NA Rat Human -DTXSID5044023 Css NA 0.001154 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044023 Css NA 0.01795 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044023 Css NA 0.005622 mg/L PBTK NA 50% Rat Human -DTXSID5044023 Css NA 0.03924 mg/L PBTK NA 95% Rat Human +DTXSID5044023 TK.Half.Life NA 2.762 hours 1compartment NA NA Rat Human +DTXSID5044023 Css NA 0.005052 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044023 Css NA 0.04125 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044023 Css NA 0.006528 mg/L PBTK NA 50% Rat Human +DTXSID5044023 Css NA 0.04226 mg/L PBTK NA 95% Rat Human DTXSID5044029 Clint 6 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID5044029 Fup NA 0.0121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044029 Vd NA 2.204 L/kg 1compartment NA NA Human Human -DTXSID5044029 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID5044029 TK.Half.Life NA 107.9 hours 1compartment NA NA Human Human -DTXSID5044029 Css NA 7.756 mg/L 3compartmentss NA 50% Human Human -DTXSID5044029 Css NA 53.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5044029 Css NA 5.036 mg/L PBTK NA 50% Human Human -DTXSID5044029 Css NA 33.41 mg/L PBTK NA 95% Human Human +DTXSID5044029 Fup 0.0381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044029 Vd NA 3.113 L/kg 1compartment NA NA Human Human +DTXSID5044029 Days.Css NA 59 Days PBTK NA NA Human Human +DTXSID5044029 TK.Half.Life NA 276.8 hours 1compartment NA NA Human Human +DTXSID5044029 Css NA 9.44 mg/L 3compartmentss NA 50% Human Human +DTXSID5044029 Css NA 60.91 mg/L 3compartmentss NA 95% Human Human +DTXSID5044029 Css NA 6.585 mg/L PBTK NA 50% Human Human +DTXSID5044029 Css NA 40.8 mg/L PBTK NA 95% Human Human DTXSID5044029 Clint 6 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID5044029 Fup NA 0.0121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044029 Vd NA 1.646 L/kg 1compartment NA NA Rat Human -DTXSID5044029 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID5044029 TK.Half.Life NA 30.96 hours 1compartment NA NA Rat Human -DTXSID5044029 Css NA 4.267 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044029 Css NA 22.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044029 Css NA 2.612 mg/L PBTK NA 50% Rat Human -DTXSID5044029 Css NA 13.08 mg/L PBTK NA 95% Rat Human +DTXSID5044029 Fup 0.0381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044029 Vd NA 2.333 L/kg 1compartment NA NA Rat Human +DTXSID5044029 Days.Css NA 32 Days PBTK NA NA Rat Human +DTXSID5044029 TK.Half.Life NA 36.4 hours 1compartment NA NA Rat Human +DTXSID5044029 Css NA 0.4768 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044029 Css NA 3.231 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044029 Css NA 0.323 mg/L PBTK NA 50% Rat Human +DTXSID5044029 Css NA 2.092 mg/L PBTK NA 95% Rat Human DTXSID5044154 Clint NA 0.0918 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5044154 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044154 Vd NA 0.9775 L/kg 1compartment NA NA Human Human +DTXSID5044154 Vd NA 0.9852 L/kg 1compartment NA NA Human Human DTXSID5044154 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044154 TK.Half.Life NA 5.55 hours 1compartment NA NA Human Human -DTXSID5044154 Css NA 0.6764 mg/L 3compartmentss NA 50% Human Human -DTXSID5044154 Css NA 4.494 mg/L 3compartmentss NA 95% Human Human -DTXSID5044154 Css NA 0.5976 mg/L PBTK NA 50% Human Human -DTXSID5044154 Css NA 3.018 mg/L PBTK NA 95% Human Human +DTXSID5044154 TK.Half.Life NA 5.599 hours 1compartment NA NA Human Human +DTXSID5044154 Css NA 0.647 mg/L 3compartmentss NA 50% Human Human +DTXSID5044154 Css NA 4.164 mg/L 3compartmentss NA 95% Human Human +DTXSID5044154 Css NA 0.5773 mg/L PBTK NA 50% Human Human +DTXSID5044154 Css NA 2.783 mg/L PBTK NA 95% Human Human DTXSID5044154 Clint NA 0.0918 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5044154 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044154 Vd NA 0.9839 L/kg 1compartment NA NA Rat Human +DTXSID5044154 Vd NA 0.9905 L/kg 1compartment NA NA Rat Human DTXSID5044154 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044154 TK.Half.Life NA 2.026 hours 1compartment NA NA Rat Human -DTXSID5044154 Css NA 0.1841 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044154 Css NA 1.271 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044154 Css NA 0.1606 mg/L PBTK NA 50% Rat Human -DTXSID5044154 Css NA 0.7739 mg/L PBTK NA 95% Rat Human -DTXSID5044233 Clint NA 2505 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044233 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044233 Vd NA 710.4 L/kg 1compartment NA NA Human Human -DTXSID5044233 Days.Css NA 32 Days PBTK NA NA Human Human -DTXSID5044233 TK.Half.Life NA 188.2 hours 1compartment NA NA Human Human -DTXSID5044233 Css NA 0.0001994 mg/L 3compartmentss NA 50% Human Human -DTXSID5044233 Css NA 0.001232 mg/L 3compartmentss NA 95% Human Human -DTXSID5044233 Css NA 0.02176 mg/L PBTK NA 50% Human Human -DTXSID5044233 Css NA 0.1232 mg/L PBTK NA 95% Human Human -DTXSID5044233 Clint NA 2505 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044233 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044233 Vd NA 646.5 L/kg 1compartment NA NA Rat Human -DTXSID5044233 Days.Css NA 25 Days PBTK NA NA Rat Human -DTXSID5044233 TK.Half.Life NA 32.11 hours 1compartment NA NA Rat Human -DTXSID5044233 Css NA 0.0001011 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044233 Css NA 0.000422 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044233 Css NA 0.01181 mg/L PBTK NA 50% Rat Human -DTXSID5044233 Css NA 0.05008 mg/L PBTK NA 95% Rat Human -DTXSID5044239 Clint NA 1.636 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044239 Fup NA 0.2752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044239 Vd NA 1.246 L/kg 1compartment NA NA Human Human +DTXSID5044154 TK.Half.Life NA 2.04 hours 1compartment NA NA Rat Human +DTXSID5044154 Css NA 0.04113 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044154 Css NA 0.2724 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044154 Css NA 0.03733 mg/L PBTK NA 50% Rat Human +DTXSID5044154 Css NA 0.1736 mg/L PBTK NA 95% Rat Human +DTXSID5044233 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044233 Fup 0.0246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044233 Vd NA 39.17 L/kg 1compartment NA NA Human Human +DTXSID5044233 Days.Css NA 286 Days PBTK NA NA Human Human +DTXSID5044233 TK.Half.Life NA 1153 hours 1compartment NA NA Human Human +DTXSID5044233 Css NA 0.5492 mg/L 3compartmentss NA 50% Human Human +DTXSID5044233 Css NA 3.663 mg/L 3compartmentss NA 95% Human Human +DTXSID5044233 Css NA 2.342 mg/L PBTK NA 50% Human Human +DTXSID5044233 Css NA 13.95 mg/L PBTK NA 95% Human Human +DTXSID5044233 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044233 Fup 0.0246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044233 Vd NA 32.7 L/kg 1compartment NA NA Rat Human +DTXSID5044233 Days.Css NA 175 Days PBTK NA NA Rat Human +DTXSID5044233 TK.Half.Life NA 164.8 hours 1compartment NA NA Rat Human +DTXSID5044233 Css NA 0.06648 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044233 Css NA 0.3069 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044233 Css NA 0.3065 mg/L PBTK NA 50% Rat Human +DTXSID5044233 Css NA 1.538 mg/L PBTK NA 95% Rat Human +DTXSID5044239 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044239 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044239 Vd NA 1.777 L/kg 1compartment NA NA Human Human DTXSID5044239 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044239 TK.Half.Life NA 8.336 hours 1compartment NA NA Human Human -DTXSID5044239 Css NA 0.6732 mg/L 3compartmentss NA 50% Human Human -DTXSID5044239 Css NA 3.343 mg/L 3compartmentss NA 95% Human Human -DTXSID5044239 Css NA 0.5314 mg/L PBTK NA 50% Human Human -DTXSID5044239 Css NA 2.274 mg/L PBTK NA 95% Human Human -DTXSID5044239 Clint NA 1.636 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044239 Fup NA 0.2752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044239 Vd NA 1.249 L/kg 1compartment NA NA Rat Human +DTXSID5044239 TK.Half.Life NA 3.809 hours 1compartment NA NA Human Human +DTXSID5044239 Css NA 0.1346 mg/L 3compartmentss NA 50% Human Human +DTXSID5044239 Css NA 0.9303 mg/L 3compartmentss NA 95% Human Human +DTXSID5044239 Css NA 0.1196 mg/L PBTK NA 50% Human Human +DTXSID5044239 Css NA 0.7056 mg/L PBTK NA 95% Human Human +DTXSID5044239 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044239 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044239 Vd NA 1.788 L/kg 1compartment NA NA Rat Human DTXSID5044239 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044239 TK.Half.Life NA 4.435 hours 1compartment NA NA Rat Human -DTXSID5044239 Css NA 0.2927 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044239 Css NA 1.174 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044239 Css NA 0.2242 mg/L PBTK NA 50% Rat Human -DTXSID5044239 Css NA 0.7332 mg/L PBTK NA 95% Rat Human -DTXSID5044289 Clint NA 9.505 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5044239 TK.Half.Life NA 2.209 hours 1compartment NA NA Rat Human +DTXSID5044239 Css NA 0.005666 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044239 Css NA 0.04853 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044239 Css NA 0.005184 mg/L PBTK NA 50% Rat Human +DTXSID5044239 Css NA 0.03537 mg/L PBTK NA 95% Rat Human +DTXSID5044281 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044281 Fup 0.28 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5044281 Vd NA 0.4795 L/kg 1compartment NA NA Human Human +DTXSID5044281 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5044281 TK.Half.Life NA 1.295 hours 1compartment NA NA Human Human +DTXSID5044281 Css NA 0.2451 mg/L 3compartmentss NA 50% Human Human +DTXSID5044281 Css NA 1.51 mg/L 3compartmentss NA 95% Human Human +DTXSID5044281 Css NA 0.1696 mg/L PBTK NA 50% Human Human +DTXSID5044281 Css NA 0.9807 mg/L PBTK NA 95% Human Human +DTXSID5044281 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044281 Fup 0.28 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5044281 Vd NA 0.4765 L/kg 1compartment NA NA Rat Human +DTXSID5044281 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5044281 TK.Half.Life NA 0.7374 hours 1compartment NA NA Rat Human +DTXSID5044281 Css NA 0.02921 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044281 Css NA 0.1336 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044281 Css NA 0.01992 mg/L PBTK NA 50% Rat Human +DTXSID5044281 Css NA 0.08317 mg/L PBTK NA 95% Rat Human +DTXSID5044289 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5044289 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5044289 Vd NA 3.948 L/kg 1compartment NA NA Human Human +DTXSID5044289 Vd NA 4.004 L/kg 1compartment NA NA Human Human DTXSID5044289 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044289 TK.Half.Life NA 3.662 hours 1compartment NA NA Human Human -DTXSID5044289 Css NA 0.04402 mg/L 3compartmentss NA 50% Human Human -DTXSID5044289 Css NA 0.5415 mg/L 3compartmentss NA 95% Human Human -DTXSID5044289 Css NA 0.06023 mg/L PBTK NA 50% Human Human -DTXSID5044289 Css NA 0.4663 mg/L PBTK NA 95% Human Human -DTXSID5044289 Clint NA 9.505 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5044289 TK.Half.Life NA 4.774 hours 1compartment NA NA Human Human +DTXSID5044289 Css NA 0.06126 mg/L 3compartmentss NA 50% Human Human +DTXSID5044289 Css NA 0.7458 mg/L 3compartmentss NA 95% Human Human +DTXSID5044289 Css NA 0.08362 mg/L PBTK NA 50% Human Human +DTXSID5044289 Css NA 0.6507 mg/L PBTK NA 95% Human Human +DTXSID5044289 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5044289 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5044289 Vd NA 4.004 L/kg 1compartment NA NA Rat Human +DTXSID5044289 Vd NA 4.06 L/kg 1compartment NA NA Rat Human DTXSID5044289 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044289 TK.Half.Life NA 2.099 hours 1compartment NA NA Rat Human -DTXSID5044289 Css NA 0.02131 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044289 Css NA 0.2383 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044289 Css NA 0.02958 mg/L PBTK NA 50% Rat Human -DTXSID5044289 Css NA 0.1875 mg/L PBTK NA 95% Rat Human -DTXSID5044314 Clint NA 91.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044314 Fup NA 0.2191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044314 Vd NA 1.927 L/kg 1compartment NA NA Human Human +DTXSID5044289 TK.Half.Life NA 2.775 hours 1compartment NA NA Rat Human +DTXSID5044289 Css NA 0.006682 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044289 Css NA 0.0736 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044289 Css NA 0.009677 mg/L PBTK NA 50% Rat Human +DTXSID5044289 Css NA 0.05928 mg/L PBTK NA 95% Rat Human +DTXSID5044314 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044314 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044314 Vd NA 1.477 L/kg 1compartment NA NA Human Human DTXSID5044314 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044314 TK.Half.Life NA 1.979 hours 1compartment NA NA Human Human -DTXSID5044314 Css NA 0.03407 mg/L 3compartmentss NA 50% Human Human -DTXSID5044314 Css NA 0.2216 mg/L 3compartmentss NA 95% Human Human -DTXSID5044314 Css NA 0.02482 mg/L PBTK NA 50% Human Human -DTXSID5044314 Css NA 0.1543 mg/L PBTK NA 95% Human Human -DTXSID5044314 Clint NA 91.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044314 Fup NA 0.2191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044314 Vd NA 1.495 L/kg 1compartment NA NA Rat Human +DTXSID5044314 TK.Half.Life NA 3.749 hours 1compartment NA NA Human Human +DTXSID5044314 Css NA 0.2581 mg/L 3compartmentss NA 50% Human Human +DTXSID5044314 Css NA 1.919 mg/L 3compartmentss NA 95% Human Human +DTXSID5044314 Css NA 0.1725 mg/L PBTK NA 50% Human Human +DTXSID5044314 Css NA 1.197 mg/L PBTK NA 95% Human Human +DTXSID5044314 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044314 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044314 Vd NA 1.138 L/kg 1compartment NA NA Rat Human DTXSID5044314 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044314 TK.Half.Life NA 0.6809 hours 1compartment NA NA Rat Human -DTXSID5044314 Css NA 0.01875 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044314 Css NA 0.1028 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044314 Css NA 0.01316 mg/L PBTK NA 50% Rat Human -DTXSID5044314 Css NA 0.06813 mg/L PBTK NA 95% Rat Human -DTXSID5044316 Clint NA 0.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044316 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044316 Vd NA 0.4776 L/kg 1compartment NA NA Human Human +DTXSID5044314 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human +DTXSID5044314 Css NA 0.03273 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044314 Css NA 0.2032 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044314 Css NA 0.0215 mg/L PBTK NA 50% Rat Human +DTXSID5044314 Css NA 0.1241 mg/L PBTK NA 95% Rat Human +DTXSID5044316 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044316 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044316 Vd NA 0.4049 L/kg 1compartment NA NA Human Human DTXSID5044316 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044316 TK.Half.Life NA 7.834 hours 1compartment NA NA Human Human -DTXSID5044316 Css NA 1.861 mg/L 3compartmentss NA 50% Human Human -DTXSID5044316 Css NA 7.666 mg/L 3compartmentss NA 95% Human Human -DTXSID5044316 Css NA 1.302 mg/L PBTK NA 50% Human Human -DTXSID5044316 Css NA 4.768 mg/L PBTK NA 95% Human Human -DTXSID5044316 Clint NA 0.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044316 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044316 Vd NA 0.4809 L/kg 1compartment NA NA Rat Human +DTXSID5044316 TK.Half.Life NA 0.4948 hours 1compartment NA NA Human Human +DTXSID5044316 Css NA 0.04763 mg/L 3compartmentss NA 50% Human Human +DTXSID5044316 Css NA 0.3861 mg/L 3compartmentss NA 95% Human Human +DTXSID5044316 Css NA 0.03293 mg/L PBTK NA 50% Human Human +DTXSID5044316 Css NA 0.2513 mg/L PBTK NA 95% Human Human +DTXSID5044316 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044316 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044316 Vd NA 0.431 L/kg 1compartment NA NA Rat Human DTXSID5044316 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044316 TK.Half.Life NA 3.371 hours 1compartment NA NA Rat Human -DTXSID5044316 Css NA 0.6588 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044316 Css NA 2.201 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044316 Css NA 0.4376 mg/L PBTK NA 50% Rat Human -DTXSID5044316 Css NA 1.283 mg/L PBTK NA 95% Rat Human -DTXSID5044318 Clint NA 0.803 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044318 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044318 Vd NA 0.229 L/kg 1compartment NA NA Human Human -DTXSID5044318 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5044318 TK.Half.Life NA 13.89 hours 1compartment NA NA Human Human -DTXSID5044318 Css NA 10.29 mg/L 3compartmentss NA 50% Human Human -DTXSID5044318 Css NA 50.74 mg/L 3compartmentss NA 95% Human Human -DTXSID5044318 Css NA 6.174 mg/L PBTK NA 50% Human Human -DTXSID5044318 Css NA 29.75 mg/L PBTK NA 95% Human Human -DTXSID5044318 Clint NA 0.803 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044318 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044318 Vd NA 0.2256 L/kg 1compartment NA NA Rat Human -DTXSID5044318 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044318 TK.Half.Life NA 6.583 hours 1compartment NA NA Rat Human -DTXSID5044318 Css NA 4.172 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044318 Css NA 16.65 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044318 Css NA 2.335 mg/L PBTK NA 50% Rat Human -DTXSID5044318 Css NA 9.072 mg/L PBTK NA 95% Rat Human -DTXSID5044360 Clint NA 21.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044360 Fup NA 0.1386 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044360 Vd NA 2.874 L/kg 1compartment NA NA Human Human -DTXSID5044360 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5044360 TK.Half.Life NA 16.24 hours 1compartment NA NA Human Human -DTXSID5044360 Css NA 0.627 mg/L 3compartmentss NA 50% Human Human -DTXSID5044360 Css NA 3.968 mg/L 3compartmentss NA 95% Human Human -DTXSID5044360 Css NA 0.4404 mg/L PBTK NA 50% Human Human -DTXSID5044360 Css NA 2.723 mg/L PBTK NA 95% Human Human -DTXSID5044360 Clint NA 21.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044360 Fup NA 0.1386 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044360 Vd NA 2.166 L/kg 1compartment NA NA Rat Human -DTXSID5044360 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044360 TK.Half.Life NA 3.263 hours 1compartment NA NA Rat Human -DTXSID5044360 Css NA 0.3525 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044360 Css NA 1.711 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044360 Css NA 0.2364 mg/L PBTK NA 50% Rat Human -DTXSID5044360 Css NA 1.113 mg/L PBTK NA 95% Rat Human -DTXSID5044362 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044362 Fup NA 0.9805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044362 Vd NA 0.8817 L/kg 1compartment NA NA Human Human +DTXSID5044316 TK.Half.Life NA 0.2726 hours 1compartment NA NA Rat Human +DTXSID5044316 Css NA 0.001665 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044316 Css NA 0.01576 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044316 Css NA 0.001127 mg/L PBTK NA 50% Rat Human +DTXSID5044316 Css NA 0.01005 mg/L PBTK NA 95% Rat Human +DTXSID5044362 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044362 Fup 0.697 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044362 Vd NA 0.6658 L/kg 1compartment NA NA Human Human DTXSID5044362 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044362 TK.Half.Life NA 5.844 hours 1compartment NA NA Human Human -DTXSID5044362 Css NA 0.7973 mg/L 3compartmentss NA 50% Human Human -DTXSID5044362 Css NA 5.786 mg/L 3compartmentss NA 95% Human Human -DTXSID5044362 Css NA 0.6955 mg/L PBTK NA 50% Human Human -DTXSID5044362 Css NA 3.844 mg/L PBTK NA 95% Human Human -DTXSID5044362 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044362 Fup NA 0.9805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044362 Vd NA 0.9031 L/kg 1compartment NA NA Rat Human +DTXSID5044362 TK.Half.Life NA 6.189 hours 1compartment NA NA Human Human +DTXSID5044362 Css NA 0.9395 mg/L 3compartmentss NA 50% Human Human +DTXSID5044362 Css NA 6.227 mg/L 3compartmentss NA 95% Human Human +DTXSID5044362 Css NA 0.7574 mg/L PBTK NA 50% Human Human +DTXSID5044362 Css NA 3.933 mg/L PBTK NA 95% Human Human +DTXSID5044362 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044362 Fup 0.697 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044362 Vd NA 0.6894 L/kg 1compartment NA NA Rat Human DTXSID5044362 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044362 TK.Half.Life NA 2.033 hours 1compartment NA NA Rat Human -DTXSID5044362 Css NA 0.201 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044362 Css NA 1.365 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044362 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID5044362 Css NA 0.8268 mg/L PBTK NA 95% Rat Human -DTXSID5044447 Clint NA 59.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044447 Fup NA 0.6096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044447 Vd NA 1.587 L/kg 1compartment NA NA Human Human +DTXSID5044362 TK.Half.Life NA 2.181 hours 1compartment NA NA Rat Human +DTXSID5044362 Css NA 0.01778 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044362 Css NA 0.1496 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044362 Css NA 0.01372 mg/L PBTK NA 50% Rat Human +DTXSID5044362 Css NA 0.09457 mg/L PBTK NA 95% Rat Human +DTXSID5044447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044447 Fup 0.301 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044447 Vd NA 1.085 L/kg 1compartment NA NA Human Human DTXSID5044447 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044447 TK.Half.Life NA 1.133 hours 1compartment NA NA Human Human -DTXSID5044447 Css NA 0.01394 mg/L 3compartmentss NA 50% Human Human -DTXSID5044447 Css NA 0.1465 mg/L 3compartmentss NA 95% Human Human -DTXSID5044447 Css NA 0.01205 mg/L PBTK NA 50% Human Human -DTXSID5044447 Css NA 0.1069 mg/L PBTK NA 95% Human Human -DTXSID5044447 Clint NA 59.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044447 Fup NA 0.6096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044447 Vd NA 1.355 L/kg 1compartment NA NA Rat Human +DTXSID5044447 TK.Half.Life NA 1.425 hours 1compartment NA NA Human Human +DTXSID5044447 Css NA 0.06925 mg/L 3compartmentss NA 50% Human Human +DTXSID5044447 Css NA 0.5236 mg/L 3compartmentss NA 95% Human Human +DTXSID5044447 Css NA 0.05134 mg/L PBTK NA 50% Human Human +DTXSID5044447 Css NA 0.3557 mg/L PBTK NA 95% Human Human +DTXSID5044447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044447 Fup 0.301 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044447 Vd NA 0.9192 L/kg 1compartment NA NA Rat Human DTXSID5044447 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044447 TK.Half.Life NA 0.4368 hours 1compartment NA NA Rat Human -DTXSID5044447 Css NA 0.007252 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044447 Css NA 0.06909 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044447 Css NA 0.006138 mg/L PBTK NA 50% Rat Human -DTXSID5044447 Css NA 0.04729 mg/L PBTK NA 95% Rat Human -DTXSID5044491 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044491 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044491 Vd NA 0.7085 L/kg 1compartment NA NA Human Human +DTXSID5044447 TK.Half.Life NA 0.6211 hours 1compartment NA NA Rat Human +DTXSID5044447 Css NA 0.008645 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044447 Css NA 0.05024 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044447 Css NA 0.006447 mg/L PBTK NA 50% Rat Human +DTXSID5044447 Css NA 0.03453 mg/L PBTK NA 95% Rat Human +DTXSID5044491 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044491 Fup 0.926 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044491 Vd NA 0.6767 L/kg 1compartment NA NA Human Human DTXSID5044491 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044491 TK.Half.Life NA 4.584 hours 1compartment NA NA Human Human -DTXSID5044491 Css NA 0.8506 mg/L 3compartmentss NA 50% Human Human -DTXSID5044491 Css NA 5.546 mg/L 3compartmentss NA 95% Human Human -DTXSID5044491 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID5044491 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID5044491 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044491 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044491 Vd NA 0.7494 L/kg 1compartment NA NA Rat Human +DTXSID5044491 TK.Half.Life NA 4.728 hours 1compartment NA NA Human Human +DTXSID5044491 Css NA 0.8734 mg/L 3compartmentss NA 50% Human Human +DTXSID5044491 Css NA 3.325 mg/L 3compartmentss NA 95% Human Human +DTXSID5044491 Css NA 0.7062 mg/L PBTK NA 50% Human Human +DTXSID5044491 Css NA 2.257 mg/L PBTK NA 95% Human Human +DTXSID5044491 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044491 Fup 0.926 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044491 Vd NA 0.7155 L/kg 1compartment NA NA Rat Human DTXSID5044491 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044491 TK.Half.Life NA 1.652 hours 1compartment NA NA Rat Human -DTXSID5044491 Css NA 0.2138 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044491 Css NA 1.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044491 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID5044491 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5044493 Clint NA 129.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044493 Fup NA 0.1774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044493 Vd NA 0.6105 L/kg 1compartment NA NA Human Human -DTXSID5044493 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044493 TK.Half.Life NA 0.6043 hours 1compartment NA NA Human Human -DTXSID5044493 Css NA 0.02195 mg/L 3compartmentss NA 50% Human Human -DTXSID5044493 Css NA 0.1687 mg/L 3compartmentss NA 95% Human Human -DTXSID5044493 Css NA 0.01481 mg/L PBTK NA 50% Human Human -DTXSID5044493 Css NA 0.1093 mg/L PBTK NA 95% Human Human -DTXSID5044493 Clint NA 129.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044493 Fup NA 0.1774 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044493 Vd NA 0.5629 L/kg 1compartment NA NA Rat Human +DTXSID5044491 TK.Half.Life NA 1.704 hours 1compartment NA NA Rat Human +DTXSID5044491 Css NA 0.05222 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044491 Css NA 0.1795 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044491 Css NA 0.04267 mg/L PBTK NA 50% Rat Human +DTXSID5044491 Css NA 0.1172 mg/L PBTK NA 95% Rat Human +DTXSID5044493 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044493 Fup 0.433 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044493 Vd NA 1.151 L/kg 1compartment NA NA Human Human +DTXSID5044493 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5044493 TK.Half.Life NA 18.4 hours 1compartment NA NA Human Human +DTXSID5044493 Css NA 1.597 mg/L 3compartmentss NA 50% Human Human +DTXSID5044493 Css NA 7.307 mg/L 3compartmentss NA 95% Human Human +DTXSID5044493 Css NA 1.289 mg/L PBTK NA 50% Human Human +DTXSID5044493 Css NA 4.86 mg/L PBTK NA 95% Human Human +DTXSID5044493 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044493 Fup 0.433 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044493 Vd NA 1.046 L/kg 1compartment NA NA Rat Human DTXSID5044493 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044493 TK.Half.Life NA 0.2651 hours 1compartment NA NA Rat Human -DTXSID5044493 Css NA 0.01244 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044493 Css NA 0.07681 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044493 Css NA 0.007979 mg/L PBTK NA 50% Rat Human -DTXSID5044493 Css NA 0.04735 mg/L PBTK NA 95% Rat Human +DTXSID5044493 TK.Half.Life NA 5.415 hours 1compartment NA NA Rat Human +DTXSID5044493 Css NA 0.1011 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044493 Css NA 0.3975 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044493 Css NA 0.08166 mg/L PBTK NA 50% Rat Human +DTXSID5044493 Css NA 0.254 mg/L PBTK NA 95% Rat Human DTXSID5044495 Clint 29.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5044495 Fup NA 0.396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044495 Vd NA 1.194 L/kg 1compartment NA NA Human Human +DTXSID5044495 Fup 0.352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044495 Vd NA 0.8925 L/kg 1compartment NA NA Human Human DTXSID5044495 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044495 TK.Half.Life NA 1.215 hours 1compartment NA NA Human Human -DTXSID5044495 Css NA 0.04072 mg/L 3compartmentss NA 50% Human Human -DTXSID5044495 Css NA 0.3074 mg/L 3compartmentss NA 95% Human Human -DTXSID5044495 Css NA 0.03188 mg/L PBTK NA 50% Human Human -DTXSID5044495 Css NA 0.215 mg/L PBTK NA 95% Human Human +DTXSID5044495 TK.Half.Life NA 0.9594 hours 1compartment NA NA Human Human +DTXSID5044495 Css NA 0.04112 mg/L 3compartmentss NA 50% Human Human +DTXSID5044495 Css NA 0.3254 mg/L 3compartmentss NA 95% Human Human +DTXSID5044495 Css NA 0.03072 mg/L PBTK NA 50% Human Human +DTXSID5044495 Css NA 0.2282 mg/L PBTK NA 95% Human Human DTXSID5044495 Clint 29.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5044495 Fup NA 0.396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044495 Vd NA 1.023 L/kg 1compartment NA NA Rat Human +DTXSID5044495 Fup 0.352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044495 Vd NA 0.7964 L/kg 1compartment NA NA Rat Human DTXSID5044495 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044495 TK.Half.Life NA 0.5108 hours 1compartment NA NA Rat Human -DTXSID5044495 Css NA 0.02147 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044495 Css NA 0.1366 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044495 Css NA 0.01628 mg/L PBTK NA 50% Rat Human -DTXSID5044495 Css NA 0.09084 mg/L PBTK NA 95% Rat Human +DTXSID5044495 TK.Half.Life NA 0.4311 hours 1compartment NA NA Rat Human +DTXSID5044495 Css NA 0.005156 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044495 Css NA 0.03237 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044495 Css NA 0.003882 mg/L PBTK NA 50% Rat Human +DTXSID5044495 Css NA 0.02257 mg/L PBTK NA 95% Rat Human DTXSID5044520 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5044520 Fup 0.0114 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5044520 Vd NA 3.091 L/kg 1compartment NA NA Human Human -DTXSID5044520 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID5044520 TK.Half.Life NA 75500 hours 1compartment NA NA Human Human -DTXSID5044520 Css NA 1776 mg/L 3compartmentss NA 50% Human Human -DTXSID5044520 Css NA 6356 mg/L 3compartmentss NA 95% Human Human -DTXSID5044520 Css NA 1271 mg/L PBTK NA 50% Human Human -DTXSID5044520 Css NA 4160 mg/L PBTK NA 95% Human Human +DTXSID5044520 Vd NA 2.244 L/kg 1compartment NA NA Human Human +DTXSID5044520 Days.Css NA 651 Days PBTK NA NA Human Human +DTXSID5044520 TK.Half.Life NA 3129 hours 1compartment NA NA Human Human +DTXSID5044520 Css NA 95.76 mg/L 3compartmentss NA 50% Human Human +DTXSID5044520 Css NA 365.9 mg/L 3compartmentss NA 95% Human Human +DTXSID5044520 Css NA 64.09 mg/L PBTK NA 50% Human Human +DTXSID5044520 Css NA 228.7 mg/L PBTK NA 95% Human Human DTXSID5044520 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5044520 Fup 0.0114 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5044520 Vd NA 2.313 L/kg 1compartment NA NA Rat Human -DTXSID5044520 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID5044520 TK.Half.Life NA 4926 hours 1compartment NA NA Rat Human -DTXSID5044520 Css NA 582.7 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044520 Css NA 1413 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044520 Css NA 404.6 mg/L PBTK NA 50% Rat Human -DTXSID5044520 Css NA 865.1 mg/L PBTK NA 95% Rat Human -DTXSID5044522 Clint NA 10.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044522 Fup NA 0.4719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044522 Vd NA 1.568 L/kg 1compartment NA NA Human Human -DTXSID5044522 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044522 TK.Half.Life NA 2.303 hours 1compartment NA NA Human Human -DTXSID5044522 Css NA 0.09576 mg/L 3compartmentss NA 50% Human Human -DTXSID5044522 Css NA 0.738 mg/L 3compartmentss NA 95% Human Human -DTXSID5044522 Css NA 0.07912 mg/L PBTK NA 50% Human Human -DTXSID5044522 Css NA 0.524 mg/L PBTK NA 95% Human Human -DTXSID5044522 Clint NA 10.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044522 Fup NA 0.4719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044522 Vd NA 1.309 L/kg 1compartment NA NA Rat Human +DTXSID5044520 Vd NA 1.667 L/kg 1compartment NA NA Rat Human +DTXSID5044520 Days.Css NA 210 Days PBTK NA NA Rat Human +DTXSID5044520 TK.Half.Life NA 434.3 hours 1compartment NA NA Rat Human +DTXSID5044520 Css NA 1.755 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044520 Css NA 10.47 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044520 Css NA 1.112 mg/L PBTK NA 50% Rat Human +DTXSID5044520 Css NA 6.477 mg/L PBTK NA 95% Rat Human +DTXSID5044522 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044522 Fup 0.599 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044522 Vd NA 1.551 L/kg 1compartment NA NA Human Human +DTXSID5044522 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5044522 TK.Half.Life NA 20.34 hours 1compartment NA NA Human Human +DTXSID5044522 Css NA 1.296 mg/L 3compartmentss NA 50% Human Human +DTXSID5044522 Css NA 8.415 mg/L 3compartmentss NA 95% Human Human +DTXSID5044522 Css NA 1.124 mg/L PBTK NA 50% Human Human +DTXSID5044522 Css NA 5.54 mg/L PBTK NA 95% Human Human +DTXSID5044522 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044522 Fup 0.599 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044522 Vd NA 1.328 L/kg 1compartment NA NA Rat Human DTXSID5044522 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044522 TK.Half.Life NA 0.9469 hours 1compartment NA NA Rat Human -DTXSID5044522 Css NA 0.05002 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044522 Css NA 0.2842 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044522 Css NA 0.03988 mg/L PBTK NA 50% Rat Human -DTXSID5044522 Css NA 0.1914 mg/L PBTK NA 95% Rat Human -DTXSID5044526 Clint NA 3.158 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044526 Fup NA 0.4151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044526 Vd NA 1.793 L/kg 1compartment NA NA Human Human +DTXSID5044522 TK.Half.Life NA 5.138 hours 1compartment NA NA Rat Human +DTXSID5044522 Css NA 0.07868 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044522 Css NA 0.4912 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044522 Css NA 0.06887 mg/L PBTK NA 50% Rat Human +DTXSID5044522 Css NA 0.3095 mg/L PBTK NA 95% Rat Human +DTXSID5044526 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044526 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044526 Vd NA 0.8726 L/kg 1compartment NA NA Human Human DTXSID5044526 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044526 TK.Half.Life NA 6.829 hours 1compartment NA NA Human Human -DTXSID5044526 Css NA 0.3628 mg/L 3compartmentss NA 50% Human Human -DTXSID5044526 Css NA 1.987 mg/L 3compartmentss NA 95% Human Human -DTXSID5044526 Css NA 0.2911 mg/L PBTK NA 50% Human Human -DTXSID5044526 Css NA 1.401 mg/L PBTK NA 95% Human Human -DTXSID5044526 Clint NA 3.158 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044526 Fup NA 0.4151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044526 Vd NA 1.451 L/kg 1compartment NA NA Rat Human +DTXSID5044526 TK.Half.Life NA 1.991 hours 1compartment NA NA Human Human +DTXSID5044526 Css NA 0.1857 mg/L 3compartmentss NA 50% Human Human +DTXSID5044526 Css NA 1.198 mg/L 3compartmentss NA 95% Human Human +DTXSID5044526 Css NA 0.1404 mg/L PBTK NA 50% Human Human +DTXSID5044526 Css NA 0.8036 mg/L PBTK NA 95% Human Human +DTXSID5044526 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044526 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044526 Vd NA 0.7821 L/kg 1compartment NA NA Rat Human DTXSID5044526 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044526 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human -DTXSID5044526 Css NA 0.1721 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044526 Css NA 0.7189 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044526 Css NA 0.1346 mg/L PBTK NA 50% Rat Human -DTXSID5044526 Css NA 0.4635 mg/L PBTK NA 95% Rat Human +DTXSID5044526 TK.Half.Life NA 0.9867 hours 1compartment NA NA Rat Human +DTXSID5044526 Css NA 0.02202 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044526 Css NA 0.1052 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044526 Css NA 0.01646 mg/L PBTK NA 50% Rat Human +DTXSID5044526 Css NA 0.06957 mg/L PBTK NA 95% Rat Human DTXSID5044528 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5044528 Fup 0.0266 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5044528 Vd NA 1.489 L/kg 1compartment NA NA Human Human -DTXSID5044528 Days.Css NA 127 Days PBTK NA NA Human Human -DTXSID5044528 TK.Half.Life NA 516.1 hours 1compartment NA NA Human Human -DTXSID5044528 Css NA 37.89 mg/L 3compartmentss NA 50% Human Human -DTXSID5044528 Css NA 162.6 mg/L 3compartmentss NA 95% Human Human -DTXSID5044528 Css NA 24.5 mg/L PBTK NA 50% Human Human -DTXSID5044528 Css NA 97.03 mg/L PBTK NA 95% Human Human +DTXSID5044528 Vd NA 1.884 L/kg 1compartment NA NA Human Human +DTXSID5044528 Days.Css NA 208 Days PBTK NA NA Human Human +DTXSID5044528 TK.Half.Life NA 820.8 hours 1compartment NA NA Human Human +DTXSID5044528 Css NA 45.12 mg/L 3compartmentss NA 50% Human Human +DTXSID5044528 Css NA 174.4 mg/L 3compartmentss NA 95% Human Human +DTXSID5044528 Css NA 29.69 mg/L PBTK NA 50% Human Human +DTXSID5044528 Css NA 106.8 mg/L PBTK NA 95% Human Human DTXSID5044528 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5044528 Fup 0.0266 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5044528 Vd NA 1.108 L/kg 1compartment NA NA Rat Human -DTXSID5044528 Days.Css NA 29 Days PBTK NA NA Rat Human -DTXSID5044528 TK.Half.Life NA 101.1 hours 1compartment NA NA Rat Human -DTXSID5044528 Css NA 10.98 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044528 Css NA 38.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044528 Css NA 6.657 mg/L PBTK NA 50% Rat Human -DTXSID5044528 Css NA 21.55 mg/L PBTK NA 95% Rat Human +DTXSID5044528 Vd NA 1.402 L/kg 1compartment NA NA Rat Human +DTXSID5044528 Days.Css NA 49 Days PBTK NA NA Rat Human +DTXSID5044528 TK.Half.Life NA 138.1 hours 1compartment NA NA Rat Human +DTXSID5044528 Css NA 2.104 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044528 Css NA 7.554 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044528 Css NA 1.37 mg/L PBTK NA 50% Rat Human +DTXSID5044528 Css NA 4.488 mg/L PBTK NA 95% Rat Human DTXSID5044570 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5044570 Fup NA 0.809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044570 Vd NA 1.22 L/kg 1compartment NA NA Human Human -DTXSID5044570 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044570 TK.Half.Life NA 9.756 hours 1compartment NA NA Human Human -DTXSID5044570 Css NA 0.8888 mg/L 3compartmentss NA 50% Human Human -DTXSID5044570 Css NA 5.503 mg/L 3compartmentss NA 95% Human Human -DTXSID5044570 Css NA 0.8137 mg/L PBTK NA 50% Human Human -DTXSID5044570 Css NA 3.685 mg/L PBTK NA 95% Human Human +DTXSID5044570 Vd NA 1.642 L/kg 1compartment NA NA Human Human +DTXSID5044570 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5044570 TK.Half.Life NA 13.13 hours 1compartment NA NA Human Human +DTXSID5044570 Css NA 0.7084 mg/L 3compartmentss NA 50% Human Human +DTXSID5044570 Css NA 4.777 mg/L 3compartmentss NA 95% Human Human +DTXSID5044570 Css NA 0.6938 mg/L PBTK NA 50% Human Human +DTXSID5044570 Css NA 3.287 mg/L PBTK NA 95% Human Human DTXSID5044570 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5044570 Fup NA 0.809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044570 Vd NA 1.256 L/kg 1compartment NA NA Rat Human +DTXSID5044570 Vd NA 1.661 L/kg 1compartment NA NA Rat Human DTXSID5044570 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044570 TK.Half.Life NA 3.423 hours 1compartment NA NA Rat Human -DTXSID5044570 Css NA 0.2228 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044570 Css NA 1.454 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044570 Css NA 0.2002 mg/L PBTK NA 50% Rat Human -DTXSID5044570 Css NA 0.901 mg/L PBTK NA 95% Rat Human -DTXSID5044572 Clint NA 0.05754 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044572 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044572 Vd NA 3.001 L/kg 1compartment NA NA Human Human -DTXSID5044572 Days.Css NA 1127 Days PBTK NA NA Human Human -DTXSID5044572 TK.Half.Life NA 4133 hours 1compartment NA NA Human Human -DTXSID5044572 Css NA 161.5 mg/L 3compartmentss NA 50% Human Human -DTXSID5044572 Css NA 464.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5044572 Css NA 112.3 mg/L PBTK NA 50% Human Human -DTXSID5044572 Css NA 296.9 mg/L PBTK NA 95% Human Human -DTXSID5044572 Clint NA 0.05754 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044572 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044572 Vd NA 2.249 L/kg 1compartment NA NA Rat Human -DTXSID5044572 Days.Css NA 331 Days PBTK NA NA Rat Human -DTXSID5044572 TK.Half.Life NA 358.6 hours 1compartment NA NA Rat Human -DTXSID5044572 Css NA 52.35 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044572 Css NA 118.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044572 Css NA 34.55 mg/L PBTK NA 50% Rat Human -DTXSID5044572 Css NA 70.88 mg/L PBTK NA 95% Rat Human -DTXSID5044576 Clint NA 65.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044576 Fup NA 0.3036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044576 Vd NA 1.033 L/kg 1compartment NA NA Human Human +DTXSID5044570 TK.Half.Life NA 4.527 hours 1compartment NA NA Rat Human +DTXSID5044570 Css NA 0.01317 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044570 Css NA 0.1125 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044570 Css NA 0.01257 mg/L PBTK NA 50% Rat Human +DTXSID5044570 Css NA 0.0792 mg/L PBTK NA 95% Rat Human +DTXSID5044574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044574 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044574 Vd NA 2.267 L/kg 1compartment NA NA Human Human +DTXSID5044574 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5044574 TK.Half.Life NA 5.432 hours 1compartment NA NA Human Human +DTXSID5044574 Css NA 0.1942 mg/L 3compartmentss NA 50% Human Human +DTXSID5044574 Css NA 1.32 mg/L 3compartmentss NA 95% Human Human +DTXSID5044574 Css NA 0.1404 mg/L PBTK NA 50% Human Human +DTXSID5044574 Css NA 0.9051 mg/L PBTK NA 95% Human Human +DTXSID5044574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044574 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044574 Vd NA 1.733 L/kg 1compartment NA NA Rat Human +DTXSID5044574 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5044574 TK.Half.Life NA 1.675 hours 1compartment NA NA Rat Human +DTXSID5044574 Css NA 0.02497 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044574 Css NA 0.1225 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044574 Css NA 0.01783 mg/L PBTK NA 50% Rat Human +DTXSID5044574 Css NA 0.08498 mg/L PBTK NA 95% Rat Human +DTXSID5044576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044576 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044576 Vd NA 0.9518 L/kg 1compartment NA NA Human Human DTXSID5044576 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044576 TK.Half.Life NA 0.955 hours 1compartment NA NA Human Human -DTXSID5044576 Css NA 0.02391 mg/L 3compartmentss NA 50% Human Human -DTXSID5044576 Css NA 0.1889 mg/L 3compartmentss NA 95% Human Human -DTXSID5044576 Css NA 0.01779 mg/L PBTK NA 50% Human Human -DTXSID5044576 Css NA 0.1282 mg/L PBTK NA 95% Human Human -DTXSID5044576 Clint NA 65.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044576 Fup NA 0.3036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044576 Vd NA 0.8831 L/kg 1compartment NA NA Rat Human +DTXSID5044576 TK.Half.Life NA 1.083 hours 1compartment NA NA Human Human +DTXSID5044576 Css NA 0.05073 mg/L 3compartmentss NA 50% Human Human +DTXSID5044576 Css NA 0.4003 mg/L 3compartmentss NA 95% Human Human +DTXSID5044576 Css NA 0.0388 mg/L PBTK NA 50% Human Human +DTXSID5044576 Css NA 0.274 mg/L PBTK NA 95% Human Human +DTXSID5044576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044576 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044576 Vd NA 0.8483 L/kg 1compartment NA NA Rat Human DTXSID5044576 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044576 TK.Half.Life NA 0.3879 hours 1compartment NA NA Rat Human -DTXSID5044576 Css NA 0.01336 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044576 Css NA 0.0811 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044576 Css NA 0.009548 mg/L PBTK NA 50% Rat Human -DTXSID5044576 Css NA 0.05265 mg/L PBTK NA 95% Rat Human -DTXSID5044578 Clint NA 0.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044578 Fup NA 0.1868 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044578 Vd NA 0.4104 L/kg 1compartment NA NA Human Human +DTXSID5044576 TK.Half.Life NA 0.493 hours 1compartment NA NA Rat Human +DTXSID5044576 Css NA 0.006282 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044576 Css NA 0.0394 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044576 Css NA 0.004832 mg/L PBTK NA 50% Rat Human +DTXSID5044576 Css NA 0.02691 mg/L PBTK NA 95% Rat Human +DTXSID5044578 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044578 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044578 Vd NA 0.436 L/kg 1compartment NA NA Human Human DTXSID5044578 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044578 TK.Half.Life NA 6.876 hours 1compartment NA NA Human Human -DTXSID5044578 Css NA 1.988 mg/L 3compartmentss NA 50% Human Human -DTXSID5044578 Css NA 8.009 mg/L 3compartmentss NA 95% Human Human -DTXSID5044578 Css NA 1.336 mg/L PBTK NA 50% Human Human -DTXSID5044578 Css NA 4.873 mg/L PBTK NA 95% Human Human -DTXSID5044578 Clint NA 0.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044578 Fup NA 0.1868 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044578 Vd NA 0.4131 L/kg 1compartment NA NA Rat Human +DTXSID5044578 TK.Half.Life NA 0.6442 hours 1compartment NA NA Human Human +DTXSID5044578 Css NA 0.09456 mg/L 3compartmentss NA 50% Human Human +DTXSID5044578 Css NA 0.6857 mg/L 3compartmentss NA 95% Human Human +DTXSID5044578 Css NA 0.0667 mg/L PBTK NA 50% Human Human +DTXSID5044578 Css NA 0.4443 mg/L PBTK NA 95% Human Human +DTXSID5044578 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044578 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044578 Vd NA 0.4614 L/kg 1compartment NA NA Rat Human DTXSID5044578 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044578 TK.Half.Life NA 3.202 hours 1compartment NA NA Rat Human -DTXSID5044578 Css NA 0.767 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044578 Css NA 2.444 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044578 Css NA 0.486 mg/L PBTK NA 50% Rat Human -DTXSID5044578 Css NA 1.405 mg/L PBTK NA 95% Rat Human -DTXSID5044603 Clint NA 2.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044603 Fup NA 0.9724 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044603 Vd NA 0.8649 L/kg 1compartment NA NA Human Human +DTXSID5044578 TK.Half.Life NA 0.3675 hours 1compartment NA NA Rat Human +DTXSID5044578 Css NA 0.01125 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044578 Css NA 0.06581 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044578 Css NA 0.007905 mg/L PBTK NA 50% Rat Human +DTXSID5044578 Css NA 0.04189 mg/L PBTK NA 95% Rat Human +DTXSID5044603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044603 Fup 0.749 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044603 Vd NA 0.7389 L/kg 1compartment NA NA Human Human DTXSID5044603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044603 TK.Half.Life NA 1.47 hours 1compartment NA NA Human Human -DTXSID5044603 Css NA 0.1824 mg/L 3compartmentss NA 50% Human Human -DTXSID5044603 Css NA 1.319 mg/L 3compartmentss NA 95% Human Human -DTXSID5044603 Css NA 0.1523 mg/L PBTK NA 50% Human Human -DTXSID5044603 Css NA 0.907 mg/L PBTK NA 95% Human Human -DTXSID5044603 Clint NA 2.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044603 Fup NA 0.9724 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044603 Vd NA 0.8959 L/kg 1compartment NA NA Rat Human +DTXSID5044603 TK.Half.Life NA 6.388 hours 1compartment NA NA Human Human +DTXSID5044603 Css NA 1.009 mg/L 3compartmentss NA 50% Human Human +DTXSID5044603 Css NA 6.402 mg/L 3compartmentss NA 95% Human Human +DTXSID5044603 Css NA 0.8258 mg/L PBTK NA 50% Human Human +DTXSID5044603 Css NA 4.08 mg/L PBTK NA 95% Human Human +DTXSID5044603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044603 Fup 0.749 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044603 Vd NA 0.7637 L/kg 1compartment NA NA Rat Human DTXSID5044603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044603 TK.Half.Life NA 0.7902 hours 1compartment NA NA Rat Human -DTXSID5044603 Css NA 0.07787 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044603 Css NA 0.4732 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044603 Css NA 0.06498 mg/L PBTK NA 50% Rat Human -DTXSID5044603 Css NA 0.2889 mg/L PBTK NA 95% Rat Human -DTXSID5044605 Clint NA 13.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044605 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044605 Vd NA 1.957 L/kg 1compartment NA NA Human Human -DTXSID5044605 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5044605 TK.Half.Life NA 34.92 hours 1compartment NA NA Human Human -DTXSID5044605 Css NA 2.892 mg/L 3compartmentss NA 50% Human Human -DTXSID5044605 Css NA 22.05 mg/L 3compartmentss NA 95% Human Human -DTXSID5044605 Css NA 1.852 mg/L PBTK NA 50% Human Human -DTXSID5044605 Css NA 13.57 mg/L PBTK NA 95% Human Human -DTXSID5044605 Clint NA 13.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044605 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044605 Vd NA 1.456 L/kg 1compartment NA NA Rat Human -DTXSID5044605 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5044605 TK.Half.Life NA 11.4 hours 1compartment NA NA Rat Human -DTXSID5044605 Css NA 1.576 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044605 Css NA 9.654 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044605 Css NA 0.9488 mg/L PBTK NA 50% Rat Human -DTXSID5044605 Css NA 5.604 mg/L PBTK NA 95% Rat Human -DTXSID5044607 Clint NA 62.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044607 Fup NA 0.1061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044607 Vd NA 1.786 L/kg 1compartment NA NA Human Human +DTXSID5044603 TK.Half.Life NA 2.249 hours 1compartment NA NA Rat Human +DTXSID5044603 Css NA 0.05999 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044603 Css NA 0.3691 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044603 Css NA 0.04905 mg/L PBTK NA 50% Rat Human +DTXSID5044603 Css NA 0.2271 mg/L PBTK NA 95% Rat Human +DTXSID5044605 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044605 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044605 Vd NA 1.863 L/kg 1compartment NA NA Human Human +DTXSID5044605 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5044605 TK.Half.Life NA 22.66 hours 1compartment NA NA Human Human +DTXSID5044605 Css NA 1.848 mg/L 3compartmentss NA 50% Human Human +DTXSID5044605 Css NA 16.01 mg/L 3compartmentss NA 95% Human Human +DTXSID5044605 Css NA 1.166 mg/L PBTK NA 50% Human Human +DTXSID5044605 Css NA 9.538 mg/L PBTK NA 95% Human Human +DTXSID5044605 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044605 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044605 Vd NA 1.384 L/kg 1compartment NA NA Rat Human +DTXSID5044605 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5044605 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human +DTXSID5044605 Css NA 0.2439 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044605 Css NA 1.658 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044605 Css NA 0.1505 mg/L PBTK NA 50% Rat Human +DTXSID5044605 Css NA 0.9932 mg/L PBTK NA 95% Rat Human +DTXSID5044607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044607 Fup 0.0949 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044607 Vd NA 1.666 L/kg 1compartment NA NA Human Human DTXSID5044607 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044607 TK.Half.Life NA 2.813 hours 1compartment NA NA Human Human -DTXSID5044607 Css NA 0.1166 mg/L 3compartmentss NA 50% Human Human -DTXSID5044607 Css NA 0.8867 mg/L 3compartmentss NA 95% Human Human -DTXSID5044607 Css NA 0.07863 mg/L PBTK NA 50% Human Human -DTXSID5044607 Css NA 0.5682 mg/L PBTK NA 95% Human Human -DTXSID5044607 Clint NA 62.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044607 Fup NA 0.1061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044607 Vd NA 1.357 L/kg 1compartment NA NA Rat Human +DTXSID5044607 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human +DTXSID5044607 Css NA 0.3388 mg/L 3compartmentss NA 50% Human Human +DTXSID5044607 Css NA 2.607 mg/L 3compartmentss NA 95% Human Human +DTXSID5044607 Css NA 0.2244 mg/L PBTK NA 50% Human Human +DTXSID5044607 Css NA 1.647 mg/L PBTK NA 95% Human Human +DTXSID5044607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044607 Fup 0.0949 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044607 Vd NA 1.264 L/kg 1compartment NA NA Rat Human DTXSID5044607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044607 TK.Half.Life NA 0.9844 hours 1compartment NA NA Rat Human -DTXSID5044607 Css NA 0.06484 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044607 Css NA 0.4195 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044607 Css NA 0.04123 mg/L PBTK NA 50% Rat Human -DTXSID5044607 Css NA 0.2513 mg/L PBTK NA 95% Rat Human -DTXSID5044655 Clint NA 15.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044655 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044655 Vd NA 3.053 L/kg 1compartment NA NA Human Human -DTXSID5044655 Days.Css NA 14 Days PBTK NA NA Human Human -DTXSID5044655 TK.Half.Life NA 87.52 hours 1compartment NA NA Human Human -DTXSID5044655 Css NA 3.582 mg/L 3compartmentss NA 50% Human Human -DTXSID5044655 Css NA 23.77 mg/L 3compartmentss NA 95% Human Human -DTXSID5044655 Css NA 2.475 mg/L PBTK NA 50% Human Human -DTXSID5044655 Css NA 15.85 mg/L PBTK NA 95% Human Human -DTXSID5044655 Clint NA 15.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044655 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044655 Vd NA 2.289 L/kg 1compartment NA NA Rat Human -DTXSID5044655 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID5044655 TK.Half.Life NA 12.95 hours 1compartment NA NA Rat Human -DTXSID5044655 Css NA 2.017 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044655 Css NA 10.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044655 Css NA 1.331 mg/L PBTK NA 50% Rat Human -DTXSID5044655 Css NA 6.616 mg/L PBTK NA 95% Rat Human -DTXSID5044734 Clint NA 0.6982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044734 Fup NA 0.7589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044734 Vd NA 2.108 L/kg 1compartment NA NA Human Human -DTXSID5044734 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044734 TK.Half.Life NA 8.631 hours 1compartment NA NA Human Human -DTXSID5044734 Css NA 0.379 mg/L 3compartmentss NA 50% Human Human -DTXSID5044734 Css NA 2.746 mg/L 3compartmentss NA 95% Human Human -DTXSID5044734 Css NA 0.3901 mg/L PBTK NA 50% Human Human -DTXSID5044734 Css NA 1.934 mg/L PBTK NA 95% Human Human -DTXSID5044734 Clint NA 0.6982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044734 Fup NA 0.7589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044734 Vd NA 2.139 L/kg 1compartment NA NA Rat Human +DTXSID5044607 TK.Half.Life NA 1.891 hours 1compartment NA NA Rat Human +DTXSID5044607 Css NA 0.04454 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044607 Css NA 0.2553 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044607 Css NA 0.029 mg/L PBTK NA 50% Rat Human +DTXSID5044607 Css NA 0.1586 mg/L PBTK NA 95% Rat Human +DTXSID5044732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044732 Fup 0.0929 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044732 Vd NA 2.089 L/kg 1compartment NA NA Human Human +DTXSID5044732 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5044732 TK.Half.Life NA 7.57 hours 1compartment NA NA Human Human +DTXSID5044732 Css NA 0.3547 mg/L 3compartmentss NA 50% Human Human +DTXSID5044732 Css NA 2.474 mg/L 3compartmentss NA 95% Human Human +DTXSID5044732 Css NA 0.239 mg/L PBTK NA 50% Human Human +DTXSID5044732 Css NA 1.584 mg/L PBTK NA 95% Human Human +DTXSID5044732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044732 Fup 0.0929 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044732 Vd NA 1.578 L/kg 1compartment NA NA Rat Human +DTXSID5044732 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5044732 TK.Half.Life NA 2.423 hours 1compartment NA NA Rat Human +DTXSID5044732 Css NA 0.01314 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044732 Css NA 0.1098 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044732 Css NA 0.008568 mg/L PBTK NA 50% Rat Human +DTXSID5044732 Css NA 0.06836 mg/L PBTK NA 95% Rat Human +DTXSID5044734 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044734 Fup 0.545 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044734 Vd NA 1.503 L/kg 1compartment NA NA Human Human +DTXSID5044734 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5044734 TK.Half.Life NA 17.85 hours 1compartment NA NA Human Human +DTXSID5044734 Css NA 1.11 mg/L 3compartmentss NA 50% Human Human +DTXSID5044734 Css NA 8.095 mg/L 3compartmentss NA 95% Human Human +DTXSID5044734 Css NA 1.014 mg/L PBTK NA 50% Human Human +DTXSID5044734 Css NA 5.313 mg/L PBTK NA 95% Human Human +DTXSID5044734 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044734 Fup 0.545 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044734 Vd NA 1.521 L/kg 1compartment NA NA Rat Human DTXSID5044734 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044734 TK.Half.Life NA 4.039 hours 1compartment NA NA Rat Human -DTXSID5044734 Css NA 0.1318 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044734 Css NA 1.042 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044734 Css NA 0.1361 mg/L PBTK NA 50% Rat Human -DTXSID5044734 Css NA 0.6713 mg/L PBTK NA 95% Rat Human -DTXSID5044738 Clint NA 20.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044738 Fup NA 0.251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044738 Vd NA 0.9157 L/kg 1compartment NA NA Human Human +DTXSID5044734 TK.Half.Life NA 6.156 hours 1compartment NA NA Rat Human +DTXSID5044734 Css NA 0.06802 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044734 Css NA 0.4384 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044734 Css NA 0.06246 mg/L PBTK NA 50% Rat Human +DTXSID5044734 Css NA 0.2804 mg/L PBTK NA 95% Rat Human +DTXSID5044738 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044738 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044738 Vd NA 1.238 L/kg 1compartment NA NA Human Human DTXSID5044738 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044738 TK.Half.Life NA 1.371 hours 1compartment NA NA Human Human -DTXSID5044738 Css NA 0.09612 mg/L 3compartmentss NA 50% Human Human -DTXSID5044738 Css NA 0.6823 mg/L 3compartmentss NA 95% Human Human -DTXSID5044738 Css NA 0.06906 mg/L PBTK NA 50% Human Human -DTXSID5044738 Css NA 0.4503 mg/L PBTK NA 95% Human Human -DTXSID5044738 Clint NA 20.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044738 Fup NA 0.251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044738 Vd NA 0.7837 L/kg 1compartment NA NA Rat Human +DTXSID5044738 TK.Half.Life NA 3.934 hours 1compartment NA NA Human Human +DTXSID5044738 Css NA 0.294 mg/L 3compartmentss NA 50% Human Human +DTXSID5044738 Css NA 1.727 mg/L 3compartmentss NA 95% Human Human +DTXSID5044738 Css NA 0.2144 mg/L PBTK NA 50% Human Human +DTXSID5044738 Css NA 1.153 mg/L PBTK NA 95% Human Human +DTXSID5044738 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044738 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044738 Vd NA 1.011 L/kg 1compartment NA NA Rat Human DTXSID5044738 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044738 TK.Half.Life NA 0.6239 hours 1compartment NA NA Rat Human -DTXSID5044738 Css NA 0.05107 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044738 Css NA 0.2756 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044738 Css NA 0.03505 mg/L PBTK NA 50% Rat Human -DTXSID5044738 Css NA 0.1755 mg/L PBTK NA 95% Rat Human -DTXSID5044782 Clint NA 1.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044782 Fup NA 0.0286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044782 Vd NA 0.1987 L/kg 1compartment NA NA Human Human -DTXSID5044782 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5044782 TK.Half.Life NA 11.82 hours 1compartment NA NA Human Human -DTXSID5044782 Css NA 10.71 mg/L 3compartmentss NA 50% Human Human -DTXSID5044782 Css NA 74.07 mg/L 3compartmentss NA 95% Human Human -DTXSID5044782 Css NA 6.295 mg/L PBTK NA 50% Human Human -DTXSID5044782 Css NA 42.97 mg/L PBTK NA 95% Human Human -DTXSID5044782 Clint NA 1.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044782 Fup NA 0.0286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044782 Vd NA 0.1962 L/kg 1compartment NA NA Rat Human +DTXSID5044738 TK.Half.Life NA 1.703 hours 1compartment NA NA Rat Human +DTXSID5044738 Css NA 0.0349 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044738 Css NA 0.1514 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044738 Css NA 0.0253 mg/L PBTK NA 50% Rat Human +DTXSID5044738 Css NA 0.09949 mg/L PBTK NA 95% Rat Human +DTXSID5044782 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044782 Fup 0.0802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044782 Vd NA 0.2193 L/kg 1compartment NA NA Human Human +DTXSID5044782 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5044782 TK.Half.Life NA 1.665 hours 1compartment NA NA Human Human +DTXSID5044782 Css NA 0.6373 mg/L 3compartmentss NA 50% Human Human +DTXSID5044782 Css NA 4.644 mg/L 3compartmentss NA 95% Human Human +DTXSID5044782 Css NA 0.382 mg/L PBTK NA 50% Human Human +DTXSID5044782 Css NA 2.752 mg/L PBTK NA 95% Human Human +DTXSID5044782 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044782 Fup 0.0802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044782 Vd NA 0.2207 L/kg 1compartment NA NA Rat Human DTXSID5044782 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044782 TK.Half.Life NA 6.388 hours 1compartment NA NA Rat Human -DTXSID5044782 Css NA 4.935 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044782 Css NA 28.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044782 Css NA 2.714 mg/L PBTK NA 50% Rat Human -DTXSID5044782 Css NA 15.17 mg/L PBTK NA 95% Rat Human -DTXSID5044784 Clint NA 1.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044784 Fup NA 0.2795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044784 Vd NA 1.677 L/kg 1compartment NA NA Human Human -DTXSID5044784 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5044784 TK.Half.Life NA 16.54 hours 1compartment NA NA Human Human -DTXSID5044784 Css NA 1.066 mg/L 3compartmentss NA 50% Human Human -DTXSID5044784 Css NA 4.659 mg/L 3compartmentss NA 95% Human Human -DTXSID5044784 Css NA 0.8048 mg/L PBTK NA 50% Human Human -DTXSID5044784 Css NA 3.152 mg/L PBTK NA 95% Human Human -DTXSID5044784 Clint NA 1.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044784 Fup NA 0.2795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044784 Vd NA 1.333 L/kg 1compartment NA NA Rat Human +DTXSID5044782 TK.Half.Life NA 1.032 hours 1compartment NA NA Rat Human +DTXSID5044782 Css NA 0.006532 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044782 Css NA 0.04122 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044782 Css NA 0.003679 mg/L PBTK NA 50% Rat Human +DTXSID5044782 Css NA 0.02289 mg/L PBTK NA 95% Rat Human +DTXSID5044784 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044784 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044784 Vd NA 2.501 L/kg 1compartment NA NA Human Human +DTXSID5044784 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5044784 TK.Half.Life NA 4.817 hours 1compartment NA NA Human Human +DTXSID5044784 Css NA 0.1376 mg/L 3compartmentss NA 50% Human Human +DTXSID5044784 Css NA 0.8893 mg/L 3compartmentss NA 95% Human Human +DTXSID5044784 Css NA 0.104 mg/L PBTK NA 50% Human Human +DTXSID5044784 Css NA 0.6413 mg/L PBTK NA 95% Human Human +DTXSID5044784 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044784 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044784 Vd NA 1.927 L/kg 1compartment NA NA Rat Human DTXSID5044784 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044784 TK.Half.Life NA 5.419 hours 1compartment NA NA Rat Human -DTXSID5044784 Css NA 0.4562 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044784 Css NA 1.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044784 Css NA 0.3318 mg/L PBTK NA 50% Rat Human -DTXSID5044784 Css NA 0.9237 mg/L PBTK NA 95% Rat Human -DTXSID5044786 Clint NA 17.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044786 Fup NA 0.0447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044786 Vd NA 2.711 L/kg 1compartment NA NA Human Human -DTXSID5044786 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5044786 TK.Half.Life NA 29.75 hours 1compartment NA NA Human Human -DTXSID5044786 Css NA 1.445 mg/L 3compartmentss NA 50% Human Human -DTXSID5044786 Css NA 8.834 mg/L 3compartmentss NA 95% Human Human -DTXSID5044786 Css NA 0.9833 mg/L PBTK NA 50% Human Human -DTXSID5044786 Css NA 5.86 mg/L PBTK NA 95% Human Human -DTXSID5044786 Clint NA 17.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044786 Fup NA 0.0447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044786 Vd NA 2.031 L/kg 1compartment NA NA Rat Human -DTXSID5044786 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5044786 TK.Half.Life NA 6.406 hours 1compartment NA NA Rat Human -DTXSID5044786 Css NA 0.7907 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044786 Css NA 4.093 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044786 Css NA 0.5104 mg/L PBTK NA 50% Rat Human -DTXSID5044786 Css NA 2.578 mg/L PBTK NA 95% Rat Human -DTXSID5044788 Clint NA 5.219 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044788 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044788 Vd NA 0.2487 L/kg 1compartment NA NA Human Human +DTXSID5044784 TK.Half.Life NA 1.395 hours 1compartment NA NA Rat Human +DTXSID5044784 Css NA 0.01717 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044784 Css NA 0.08755 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044784 Css NA 0.01302 mg/L PBTK NA 50% Rat Human +DTXSID5044784 Css NA 0.06291 mg/L PBTK NA 95% Rat Human +DTXSID5044786 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044786 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044786 Vd NA 1.871 L/kg 1compartment NA NA Human Human +DTXSID5044786 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5044786 TK.Half.Life NA 5.332 hours 1compartment NA NA Human Human +DTXSID5044786 Css NA 0.294 mg/L 3compartmentss NA 50% Human Human +DTXSID5044786 Css NA 2.186 mg/L 3compartmentss NA 95% Human Human +DTXSID5044786 Css NA 0.2005 mg/L PBTK NA 50% Human Human +DTXSID5044786 Css NA 1.401 mg/L PBTK NA 95% Human Human +DTXSID5044786 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044786 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044786 Vd NA 1.428 L/kg 1compartment NA NA Rat Human +DTXSID5044786 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5044786 TK.Half.Life NA 1.869 hours 1compartment NA NA Rat Human +DTXSID5044786 Css NA 0.03804 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044786 Css NA 0.2191 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044786 Css NA 0.02543 mg/L PBTK NA 50% Rat Human +DTXSID5044786 Css NA 0.139 mg/L PBTK NA 95% Rat Human +DTXSID5044788 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044788 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044788 Vd NA 0.3901 L/kg 1compartment NA NA Human Human DTXSID5044788 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044788 TK.Half.Life NA 2.704 hours 1compartment NA NA Human Human -DTXSID5044788 Css NA 1.807 mg/L 3compartmentss NA 50% Human Human -DTXSID5044788 Css NA 11.45 mg/L 3compartmentss NA 95% Human Human -DTXSID5044788 Css NA 1.092 mg/L PBTK NA 50% Human Human -DTXSID5044788 Css NA 6.733 mg/L PBTK NA 95% Human Human -DTXSID5044788 Clint NA 5.219 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044788 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044788 Vd NA 0.2494 L/kg 1compartment NA NA Rat Human +DTXSID5044788 TK.Half.Life NA 1.362 hours 1compartment NA NA Human Human +DTXSID5044788 Css NA 0.3504 mg/L 3compartmentss NA 50% Human Human +DTXSID5044788 Css NA 2.144 mg/L 3compartmentss NA 95% Human Human +DTXSID5044788 Css NA 0.233 mg/L PBTK NA 50% Human Human +DTXSID5044788 Css NA 1.34 mg/L PBTK NA 95% Human Human +DTXSID5044788 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044788 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044788 Vd NA 0.3955 L/kg 1compartment NA NA Rat Human DTXSID5044788 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044788 TK.Half.Life NA 1.669 hours 1compartment NA NA Rat Human -DTXSID5044788 Css NA 0.9448 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044788 Css NA 4.398 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044788 Css NA 0.5336 mg/L PBTK NA 50% Rat Human -DTXSID5044788 Css NA 2.407 mg/L PBTK NA 95% Rat Human -DTXSID5044811 Clint NA 50.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044811 Fup NA 0.3259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044811 Vd NA 3.814 L/kg 1compartment NA NA Human Human -DTXSID5044811 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044811 TK.Half.Life NA 2.835 hours 1compartment NA NA Human Human -DTXSID5044811 Css NA 0.02206 mg/L 3compartmentss NA 50% Human Human -DTXSID5044811 Css NA 0.173 mg/L 3compartmentss NA 95% Human Human -DTXSID5044811 Css NA 0.02407 mg/L PBTK NA 50% Human Human -DTXSID5044811 Css NA 0.1573 mg/L PBTK NA 95% Human Human -DTXSID5044811 Clint NA 50.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044811 Fup NA 0.3259 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044811 Vd NA 3.634 L/kg 1compartment NA NA Rat Human -DTXSID5044811 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044811 TK.Half.Life NA 1.254 hours 1compartment NA NA Rat Human -DTXSID5044811 Css NA 0.01153 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044811 Css NA 0.07304 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044811 Css NA 0.01268 mg/L PBTK NA 50% Rat Human -DTXSID5044811 Css NA 0.06632 mg/L PBTK NA 95% Rat Human -DTXSID5044815 Clint NA 12.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044815 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044815 Vd NA 3.061 L/kg 1compartment NA NA Human Human -DTXSID5044815 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID5044815 TK.Half.Life NA 112.4 hours 1compartment NA NA Human Human -DTXSID5044815 Css NA 4.598 mg/L 3compartmentss NA 50% Human Human -DTXSID5044815 Css NA 28.85 mg/L 3compartmentss NA 95% Human Human -DTXSID5044815 Css NA 3.174 mg/L PBTK NA 50% Human Human -DTXSID5044815 Css NA 19.45 mg/L PBTK NA 95% Human Human -DTXSID5044815 Clint NA 12.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044815 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044815 Vd NA 2.293 L/kg 1compartment NA NA Rat Human -DTXSID5044815 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID5044815 TK.Half.Life NA 16.23 hours 1compartment NA NA Rat Human -DTXSID5044815 Css NA 2.581 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044815 Css NA 12.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044815 Css NA 1.7 mg/L PBTK NA 50% Rat Human -DTXSID5044815 Css NA 8.243 mg/L PBTK NA 95% Rat Human -DTXSID5044817 Clint NA 3.265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044817 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044817 Vd NA 2.749 L/kg 1compartment NA NA Human Human -DTXSID5044817 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID5044817 TK.Half.Life NA 169.5 hours 1compartment NA NA Human Human -DTXSID5044817 Css NA 8.678 mg/L 3compartmentss NA 50% Human Human -DTXSID5044817 Css NA 46.62 mg/L 3compartmentss NA 95% Human Human -DTXSID5044817 Css NA 5.878 mg/L PBTK NA 50% Human Human -DTXSID5044817 Css NA 29.8 mg/L PBTK NA 95% Human Human -DTXSID5044817 Clint NA 3.265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044817 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044817 Vd NA 2.058 L/kg 1compartment NA NA Rat Human -DTXSID5044817 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID5044817 TK.Half.Life NA 32.13 hours 1compartment NA NA Rat Human -DTXSID5044817 Css NA 4.522 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044817 Css NA 17.98 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044817 Css NA 2.916 mg/L PBTK NA 50% Rat Human -DTXSID5044817 Css NA 11.05 mg/L PBTK NA 95% Rat Human +DTXSID5044788 TK.Half.Life NA 0.8128 hours 1compartment NA NA Rat Human +DTXSID5044788 Css NA 0.04248 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044788 Css NA 0.1748 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044788 Css NA 0.02769 mg/L PBTK NA 50% Rat Human +DTXSID5044788 Css NA 0.1064 mg/L PBTK NA 95% Rat Human +DTXSID5044815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044815 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044815 Vd NA 3.998 L/kg 1compartment NA NA Human Human +DTXSID5044815 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID5044815 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human +DTXSID5044815 Css NA 1.739 mg/L 3compartmentss NA 50% Human Human +DTXSID5044815 Css NA 11.05 mg/L 3compartmentss NA 95% Human Human +DTXSID5044815 Css NA 1.301 mg/L PBTK NA 50% Human Human +DTXSID5044815 Css NA 8.062 mg/L PBTK NA 95% Human Human +DTXSID5044815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044815 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044815 Vd NA 3.026 L/kg 1compartment NA NA Rat Human +DTXSID5044815 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID5044815 TK.Half.Life NA 16.22 hours 1compartment NA NA Rat Human +DTXSID5044815 Css NA 0.01896 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044815 Css NA 0.1173 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044815 Css NA 0.01367 mg/L PBTK NA 50% Rat Human +DTXSID5044815 Css NA 0.08385 mg/L PBTK NA 95% Rat Human +DTXSID5044817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044817 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044817 Vd NA 3.082 L/kg 1compartment NA NA Human Human +DTXSID5044817 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID5044817 TK.Half.Life NA 62.79 hours 1compartment NA NA Human Human +DTXSID5044817 Css NA 2.425 mg/L 3compartmentss NA 50% Human Human +DTXSID5044817 Css NA 15.7 mg/L 3compartmentss NA 95% Human Human +DTXSID5044817 Css NA 1.689 mg/L PBTK NA 50% Human Human +DTXSID5044817 Css NA 10.57 mg/L PBTK NA 95% Human Human +DTXSID5044817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044817 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044817 Vd NA 2.31 L/kg 1compartment NA NA Rat Human +DTXSID5044817 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID5044817 TK.Half.Life NA 9.087 hours 1compartment NA NA Rat Human +DTXSID5044817 Css NA 0.3119 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044817 Css NA 1.812 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044817 Css NA 0.2137 mg/L PBTK NA 50% Rat Human +DTXSID5044817 Css NA 1.234 mg/L PBTK NA 95% Rat Human DTXSID5044819 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5044819 Fup NA 0.3198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044819 Vd NA 0.4169 L/kg 1compartment NA NA Human Human +DTXSID5044819 Vd NA 0.4304 L/kg 1compartment NA NA Human Human DTXSID5044819 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044819 TK.Half.Life NA 8.434 hours 1compartment NA NA Human Human -DTXSID5044819 Css NA 2.376 mg/L 3compartmentss NA 50% Human Human -DTXSID5044819 Css NA 9.51 mg/L 3compartmentss NA 95% Human Human -DTXSID5044819 Css NA 1.659 mg/L PBTK NA 50% Human Human -DTXSID5044819 Css NA 5.882 mg/L PBTK NA 95% Human Human +DTXSID5044819 TK.Half.Life NA 8.708 hours 1compartment NA NA Human Human +DTXSID5044819 Css NA 2.009 mg/L 3compartmentss NA 50% Human Human +DTXSID5044819 Css NA 8.198 mg/L 3compartmentss NA 95% Human Human +DTXSID5044819 Css NA 1.404 mg/L PBTK NA 50% Human Human +DTXSID5044819 Css NA 5.11 mg/L PBTK NA 95% Human Human DTXSID5044819 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5044819 Fup NA 0.3198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044819 Vd NA 0.4337 L/kg 1compartment NA NA Rat Human +DTXSID5044819 Vd NA 0.4455 L/kg 1compartment NA NA Rat Human DTXSID5044819 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044819 TK.Half.Life NA 2.992 hours 1compartment NA NA Rat Human -DTXSID5044819 Css NA 0.6619 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044819 Css NA 2.245 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044819 Css NA 0.4351 mg/L PBTK NA 50% Rat Human -DTXSID5044819 Css NA 1.301 mg/L PBTK NA 95% Rat Human -DTXSID5044863 Clint NA 1.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044863 Fup NA 0.8171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044863 Vd NA 1.081 L/kg 1compartment NA NA Human Human +DTXSID5044819 TK.Half.Life NA 3.072 hours 1compartment NA NA Rat Human +DTXSID5044819 Css NA 0.03644 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044819 Css NA 0.2168 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044819 Css NA 0.0245 mg/L PBTK NA 50% Rat Human +DTXSID5044819 Css NA 0.1346 mg/L PBTK NA 95% Rat Human +DTXSID5044863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044863 Fup 0.636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044863 Vd NA 0.8955 L/kg 1compartment NA NA Human Human DTXSID5044863 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044863 TK.Half.Life NA 2.858 hours 1compartment NA NA Human Human -DTXSID5044863 Css NA 0.2777 mg/L 3compartmentss NA 50% Human Human -DTXSID5044863 Css NA 1.935 mg/L 3compartmentss NA 95% Human Human -DTXSID5044863 Css NA 0.2416 mg/L PBTK NA 50% Human Human -DTXSID5044863 Css NA 1.311 mg/L PBTK NA 95% Human Human -DTXSID5044863 Clint NA 1.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044863 Fup NA 0.8171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044863 Vd NA 1.035 L/kg 1compartment NA NA Rat Human +DTXSID5044863 TK.Half.Life NA 9.308 hours 1compartment NA NA Human Human +DTXSID5044863 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human +DTXSID5044863 Css NA 7.706 mg/L 3compartmentss NA 95% Human Human +DTXSID5044863 Css NA 0.921 mg/L PBTK NA 50% Human Human +DTXSID5044863 Css NA 4.923 mg/L PBTK NA 95% Human Human +DTXSID5044863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044863 Fup 0.636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044863 Vd NA 0.865 L/kg 1compartment NA NA Rat Human DTXSID5044863 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044863 TK.Half.Life NA 1.355 hours 1compartment NA NA Rat Human -DTXSID5044863 Css NA 0.1111 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044863 Css NA 0.752 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044863 Css NA 0.09542 mg/L PBTK NA 50% Rat Human -DTXSID5044863 Css NA 0.4596 mg/L PBTK NA 95% Rat Human -DTXSID5044865 Clint NA 6.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044865 Fup NA 0.1124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044865 Vd NA 3.154 L/kg 1compartment NA NA Human Human -DTXSID5044865 Days.Css NA 46 Days PBTK NA NA Human Human -DTXSID5044865 TK.Half.Life NA 223.1 hours 1compartment NA NA Human Human -DTXSID5044865 Css NA 8.614 mg/L 3compartmentss NA 50% Human Human -DTXSID5044865 Css NA 52.24 mg/L 3compartmentss NA 95% Human Human -DTXSID5044865 Css NA 6.033 mg/L PBTK NA 50% Human Human -DTXSID5044865 Css NA 35.22 mg/L PBTK NA 95% Human Human -DTXSID5044865 Clint NA 6.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044865 Fup NA 0.1124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044865 Vd NA 2.376 L/kg 1compartment NA NA Rat Human -DTXSID5044865 Days.Css NA 25 Days PBTK NA NA Rat Human -DTXSID5044865 TK.Half.Life NA 29.12 hours 1compartment NA NA Rat Human -DTXSID5044865 Css NA 4.767 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044865 Css NA 23.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044865 Css NA 3.206 mg/L PBTK NA 50% Rat Human -DTXSID5044865 Css NA 15.5 mg/L PBTK NA 95% Rat Human -DTXSID5044867 Clint NA 0.4315 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044867 Fup NA 0.1838 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044867 Vd NA 2.033 L/kg 1compartment NA NA Human Human -DTXSID5044867 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID5044867 TK.Half.Life NA 70.56 hours 1compartment NA NA Human Human -DTXSID5044867 Css NA 3.929 mg/L 3compartmentss NA 50% Human Human -DTXSID5044867 Css NA 13.44 mg/L 3compartmentss NA 95% Human Human -DTXSID5044867 Css NA 2.849 mg/L PBTK NA 50% Human Human -DTXSID5044867 Css NA 8.775 mg/L PBTK NA 95% Human Human -DTXSID5044867 Clint NA 0.4315 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044867 Fup NA 0.1838 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044867 Vd NA 1.563 L/kg 1compartment NA NA Rat Human -DTXSID5044867 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5044867 TK.Half.Life NA 15.88 hours 1compartment NA NA Rat Human -DTXSID5044867 Css NA 1.44 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044867 Css NA 3.808 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044867 Css NA 0.9923 mg/L PBTK NA 50% Rat Human -DTXSID5044867 Css NA 2.306 mg/L PBTK NA 95% Rat Human -DTXSID5044940 Clint NA 13.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044940 Fup NA 0.1223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044940 Vd NA 3.043 L/kg 1compartment NA NA Human Human -DTXSID5044940 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID5044940 TK.Half.Life NA 47.12 hours 1compartment NA NA Human Human -DTXSID5044940 Css NA 1.862 mg/L 3compartmentss NA 50% Human Human -DTXSID5044940 Css NA 11.38 mg/L 3compartmentss NA 95% Human Human -DTXSID5044940 Css NA 1.3 mg/L PBTK NA 50% Human Human -DTXSID5044940 Css NA 7.575 mg/L PBTK NA 95% Human Human -DTXSID5044940 Clint NA 13.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044940 Fup NA 0.1223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044940 Vd NA 2.285 L/kg 1compartment NA NA Rat Human +DTXSID5044863 TK.Half.Life NA 3.015 hours 1compartment NA NA Rat Human +DTXSID5044863 Css NA 0.06638 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044863 Css NA 0.4224 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044863 Css NA 0.05556 mg/L PBTK NA 50% Rat Human +DTXSID5044863 Css NA 0.2609 mg/L PBTK NA 95% Rat Human +DTXSID5044865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044865 Fup 0.0672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044865 Vd NA 3.143 L/kg 1compartment NA NA Human Human +DTXSID5044865 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID5044865 TK.Half.Life NA 76.55 hours 1compartment NA NA Human Human +DTXSID5044865 Css NA 1.562 mg/L 3compartmentss NA 50% Human Human +DTXSID5044865 Css NA 10.2 mg/L 3compartmentss NA 95% Human Human +DTXSID5044865 Css NA 1.091 mg/L PBTK NA 50% Human Human +DTXSID5044865 Css NA 6.877 mg/L PBTK NA 95% Human Human +DTXSID5044865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044865 Fup 0.0672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044865 Vd NA 2.362 L/kg 1compartment NA NA Rat Human +DTXSID5044865 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID5044865 TK.Half.Life NA 10.38 hours 1compartment NA NA Rat Human +DTXSID5044865 Css NA 0.01702 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044865 Css NA 0.1086 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044865 Css NA 0.01144 mg/L PBTK NA 50% Rat Human +DTXSID5044865 Css NA 0.07259 mg/L PBTK NA 95% Rat Human +DTXSID5044867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044867 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044867 Vd NA 2.325 L/kg 1compartment NA NA Human Human +DTXSID5044867 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5044867 TK.Half.Life NA 4.384 hours 1compartment NA NA Human Human +DTXSID5044867 Css NA 0.1331 mg/L 3compartmentss NA 50% Human Human +DTXSID5044867 Css NA 0.8731 mg/L 3compartmentss NA 95% Human Human +DTXSID5044867 Css NA 0.09976 mg/L PBTK NA 50% Human Human +DTXSID5044867 Css NA 0.6091 mg/L PBTK NA 95% Human Human +DTXSID5044867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044867 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044867 Vd NA 1.795 L/kg 1compartment NA NA Rat Human +DTXSID5044867 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5044867 TK.Half.Life NA 1.359 hours 1compartment NA NA Rat Human +DTXSID5044867 Css NA 0.01679 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044867 Css NA 0.0833 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044867 Css NA 0.01264 mg/L PBTK NA 50% Rat Human +DTXSID5044867 Css NA 0.06015 mg/L PBTK NA 95% Rat Human +DTXSID5044940 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044940 Fup 0.0384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044940 Vd NA 2.976 L/kg 1compartment NA NA Human Human +DTXSID5044940 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5044940 TK.Half.Life NA 44.63 hours 1compartment NA NA Human Human +DTXSID5044940 Css NA 1.811 mg/L 3compartmentss NA 50% Human Human +DTXSID5044940 Css NA 12.78 mg/L 3compartmentss NA 95% Human Human +DTXSID5044940 Css NA 1.244 mg/L PBTK NA 50% Human Human +DTXSID5044940 Css NA 8.499 mg/L PBTK NA 95% Human Human +DTXSID5044940 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044940 Fup 0.0384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044940 Vd NA 2.23 L/kg 1compartment NA NA Rat Human DTXSID5044940 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5044940 TK.Half.Life NA 7.272 hours 1compartment NA NA Rat Human -DTXSID5044940 Css NA 1.028 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044940 Css NA 5.004 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044940 Css NA 0.6898 mg/L PBTK NA 50% Rat Human -DTXSID5044940 Css NA 3.247 mg/L PBTK NA 95% Rat Human -DTXSID5044948 Clint NA 38.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044948 Fup NA 0.1897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044948 Vd NA 0.8251 L/kg 1compartment NA NA Human Human +DTXSID5044940 TK.Half.Life NA 7.42 hours 1compartment NA NA Rat Human +DTXSID5044940 Css NA 0.237 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044940 Css NA 1.336 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044940 Css NA 0.1609 mg/L PBTK NA 50% Rat Human +DTXSID5044940 Css NA 0.8897 mg/L PBTK NA 95% Rat Human +DTXSID5044948 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044948 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044948 Vd NA 0.6335 L/kg 1compartment NA NA Human Human DTXSID5044948 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044948 TK.Half.Life NA 1.107 hours 1compartment NA NA Human Human -DTXSID5044948 Css NA 0.07101 mg/L 3compartmentss NA 50% Human Human -DTXSID5044948 Css NA 0.4906 mg/L 3compartmentss NA 95% Human Human -DTXSID5044948 Css NA 0.04802 mg/L PBTK NA 50% Human Human -DTXSID5044948 Css NA 0.3148 mg/L PBTK NA 95% Human Human -DTXSID5044948 Clint NA 38.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044948 Fup NA 0.1897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044948 Vd NA 0.6802 L/kg 1compartment NA NA Rat Human +DTXSID5044948 TK.Half.Life NA 3.18 hours 1compartment NA NA Human Human +DTXSID5044948 Css NA 0.6516 mg/L 3compartmentss NA 50% Human Human +DTXSID5044948 Css NA 4.503 mg/L 3compartmentss NA 95% Human Human +DTXSID5044948 Css NA 0.42 mg/L PBTK NA 50% Human Human +DTXSID5044948 Css NA 2.723 mg/L PBTK NA 95% Human Human +DTXSID5044948 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044948 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044948 Vd NA 0.5277 L/kg 1compartment NA NA Rat Human DTXSID5044948 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044948 TK.Half.Life NA 0.4706 hours 1compartment NA NA Rat Human -DTXSID5044948 Css NA 0.03937 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044948 Css NA 0.2172 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044948 Css NA 0.02541 mg/L PBTK NA 50% Rat Human -DTXSID5044948 Css NA 0.134 mg/L PBTK NA 95% Rat Human +DTXSID5044948 TK.Half.Life NA 1.552 hours 1compartment NA NA Rat Human +DTXSID5044948 Css NA 0.07984 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044948 Css NA 0.4143 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044948 Css NA 0.04992 mg/L PBTK NA 50% Rat Human +DTXSID5044948 Css NA 0.2435 mg/L PBTK NA 95% Rat Human DTXSID5044992 Clint 11.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5044992 Fup 0.0166 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5044992 Vd NA 2.948 L/kg 1compartment NA NA Human Human -DTXSID5044992 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID5044992 TK.Half.Life NA 108.5 hours 1compartment NA NA Human Human -DTXSID5044992 Css NA 4.479 mg/L 3compartmentss NA 50% Human Human -DTXSID5044992 Css NA 28.47 mg/L 3compartmentss NA 95% Human Human -DTXSID5044992 Css NA 3.104 mg/L PBTK NA 50% Human Human -DTXSID5044992 Css NA 19.17 mg/L PBTK NA 95% Human Human +DTXSID5044992 Vd NA 1.155 L/kg 1compartment NA NA Human Human +DTXSID5044992 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5044992 TK.Half.Life NA 21.26 hours 1compartment NA NA Human Human +DTXSID5044992 Css NA 2.196 mg/L 3compartmentss NA 50% Human Human +DTXSID5044992 Css NA 13.09 mg/L 3compartmentss NA 95% Human Human +DTXSID5044992 Css NA 1.369 mg/L PBTK NA 50% Human Human +DTXSID5044992 Css NA 8.03 mg/L PBTK NA 95% Human Human DTXSID5044992 Clint 11.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5044992 Fup 0.0166 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5044992 Vd NA 2.205 L/kg 1compartment NA NA Rat Human -DTXSID5044992 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID5044992 TK.Half.Life NA 17.86 hours 1compartment NA NA Rat Human -DTXSID5044992 Css NA 2.49 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044992 Css NA 12.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044992 Css NA 1.639 mg/L PBTK NA 50% Rat Human -DTXSID5044992 Css NA 8.368 mg/L PBTK NA 95% Rat Human -DTXSID5044994 Clint NA 3.077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044994 Fup NA 0.0485 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044994 Vd NA 2.923 L/kg 1compartment NA NA Human Human -DTXSID5044994 Days.Css NA 45 Days PBTK NA NA Human Human -DTXSID5044994 TK.Half.Life NA 219.9 hours 1compartment NA NA Human Human -DTXSID5044994 Css NA 9.786 mg/L 3compartmentss NA 50% Human Human -DTXSID5044994 Css NA 53.56 mg/L 3compartmentss NA 95% Human Human -DTXSID5044994 Css NA 6.754 mg/L PBTK NA 50% Human Human -DTXSID5044994 Css NA 35.67 mg/L PBTK NA 95% Human Human -DTXSID5044994 Clint NA 3.077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044994 Fup NA 0.0485 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044994 Vd NA 2.191 L/kg 1compartment NA NA Rat Human -DTXSID5044994 Days.Css NA 23 Days PBTK NA NA Rat Human -DTXSID5044994 TK.Half.Life NA 35.29 hours 1compartment NA NA Rat Human -DTXSID5044994 Css NA 5.23 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044994 Css NA 19.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044994 Css NA 3.415 mg/L PBTK NA 50% Rat Human -DTXSID5044994 Css NA 12.63 mg/L PBTK NA 95% Rat Human -DTXSID5044998 Clint NA 38.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044998 Fup NA 0.0301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5044998 Vd NA 1.009 L/kg 1compartment NA NA Human Human +DTXSID5044992 Vd NA 0.8565 L/kg 1compartment NA NA Rat Human +DTXSID5044992 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5044992 TK.Half.Life NA 8.944 hours 1compartment NA NA Rat Human +DTXSID5044992 Css NA 0.2814 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044992 Css NA 1.333 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044992 Css NA 0.1706 mg/L PBTK NA 50% Rat Human +DTXSID5044992 Css NA 0.7919 mg/L PBTK NA 95% Rat Human +DTXSID5044994 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044994 Fup 0.0182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044994 Vd NA 2.618 L/kg 1compartment NA NA Human Human +DTXSID5044994 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5044994 TK.Half.Life NA 36.71 hours 1compartment NA NA Human Human +DTXSID5044994 Css NA 1.887 mg/L 3compartmentss NA 50% Human Human +DTXSID5044994 Css NA 14.27 mg/L 3compartmentss NA 95% Human Human +DTXSID5044994 Css NA 1.245 mg/L PBTK NA 50% Human Human +DTXSID5044994 Css NA 9.048 mg/L PBTK NA 95% Human Human +DTXSID5044994 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044994 Fup 0.0182 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044994 Vd NA 1.954 L/kg 1compartment NA NA Rat Human +DTXSID5044994 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5044994 TK.Half.Life NA 8.345 hours 1compartment NA NA Rat Human +DTXSID5044994 Css NA 0.2452 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044994 Css NA 1.509 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044994 Css NA 0.1606 mg/L PBTK NA 50% Rat Human +DTXSID5044994 Css NA 0.956 mg/L PBTK NA 95% Rat Human +DTXSID5044998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044998 Fup 0.0694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5044998 Vd NA 1.504 L/kg 1compartment NA NA Human Human DTXSID5044998 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5044998 TK.Half.Life NA 4.111 hours 1compartment NA NA Human Human -DTXSID5044998 Css NA 0.582 mg/L 3compartmentss NA 50% Human Human -DTXSID5044998 Css NA 5.481 mg/L 3compartmentss NA 95% Human Human -DTXSID5044998 Css NA 0.3584 mg/L PBTK NA 50% Human Human -DTXSID5044998 Css NA 3.244 mg/L PBTK NA 95% Human Human -DTXSID5044998 Clint NA 38.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044998 Fup NA 0.0301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5044998 Vd NA 0.7591 L/kg 1compartment NA NA Rat Human +DTXSID5044998 TK.Half.Life NA 5.559 hours 1compartment NA NA Human Human +DTXSID5044998 Css NA 0.4474 mg/L 3compartmentss NA 50% Human Human +DTXSID5044998 Css NA 3.355 mg/L 3compartmentss NA 95% Human Human +DTXSID5044998 Css NA 0.2899 mg/L PBTK NA 50% Human Human +DTXSID5044998 Css NA 2.131 mg/L PBTK NA 95% Human Human +DTXSID5044998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044998 Fup 0.0694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5044998 Vd NA 1.139 L/kg 1compartment NA NA Rat Human DTXSID5044998 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5044998 TK.Half.Life NA 1.773 hours 1compartment NA NA Rat Human -DTXSID5044998 Css NA 0.3342 mg/L 3compartmentss NA 50% Rat Human -DTXSID5044998 Css NA 2.499 mg/L 3compartmentss NA 95% Rat Human -DTXSID5044998 Css NA 0.1926 mg/L PBTK NA 50% Rat Human -DTXSID5044998 Css NA 1.397 mg/L PBTK NA 95% Rat Human +DTXSID5044998 TK.Half.Life NA 2.147 hours 1compartment NA NA Rat Human +DTXSID5044998 Css NA 0.05948 mg/L 3compartmentss NA 50% Rat Human +DTXSID5044998 Css NA 0.3317 mg/L 3compartmentss NA 95% Rat Human +DTXSID5044998 Css NA 0.03762 mg/L PBTK NA 50% Rat Human +DTXSID5044998 Css NA 0.2025 mg/L PBTK NA 95% Rat Human DTXSID5045043 Clint 7.399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5045043 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5045043 Vd NA 1.03 L/kg 1compartment NA NA Human Human -DTXSID5045043 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045043 TK.Half.Life NA 7.076 hours 1compartment NA NA Human Human -DTXSID5045043 Css NA 0.8168 mg/L 3compartmentss NA 50% Human Human -DTXSID5045043 Css NA 5.896 mg/L 3compartmentss NA 95% Human Human -DTXSID5045043 Css NA 0.618 mg/L PBTK NA 50% Human Human -DTXSID5045043 Css NA 3.925 mg/L PBTK NA 95% Human Human +DTXSID5045043 Vd NA 1.607 L/kg 1compartment NA NA Human Human +DTXSID5045043 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5045043 TK.Half.Life NA 12.63 hours 1compartment NA NA Human Human +DTXSID5045043 Css NA 0.8966 mg/L 3compartmentss NA 50% Human Human +DTXSID5045043 Css NA 5.568 mg/L 3compartmentss NA 95% Human Human +DTXSID5045043 Css NA 0.7257 mg/L PBTK NA 50% Human Human +DTXSID5045043 Css NA 4.508 mg/L PBTK NA 95% Human Human DTXSID5045043 Clint 7.399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID5045043 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5045043 Vd NA 0.8127 L/kg 1compartment NA NA Rat Human +DTXSID5045043 Vd NA 1.231 L/kg 1compartment NA NA Rat Human DTXSID5045043 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045043 TK.Half.Life NA 3.199 hours 1compartment NA NA Rat Human -DTXSID5045043 Css NA 0.465 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045043 Css NA 2.564 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045043 Css NA 0.3355 mg/L PBTK NA 50% Rat Human -DTXSID5045043 Css NA 1.6 mg/L PBTK NA 95% Rat Human -DTXSID5045091 Clint NA 77.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045091 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045091 Vd NA 3.067 L/kg 1compartment NA NA Human Human -DTXSID5045091 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045091 TK.Half.Life NA 12.14 hours 1compartment NA NA Human Human -DTXSID5045091 Css NA 0.4074 mg/L 3compartmentss NA 50% Human Human -DTXSID5045091 Css NA 2.604 mg/L 3compartmentss NA 95% Human Human -DTXSID5045091 Css NA 0.2814 mg/L PBTK NA 50% Human Human -DTXSID5045091 Css NA 1.748 mg/L PBTK NA 95% Human Human -DTXSID5045091 Clint NA 77.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045091 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045091 Vd NA 2.307 L/kg 1compartment NA NA Rat Human -DTXSID5045091 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045091 TK.Half.Life NA 2.231 hours 1compartment NA NA Rat Human -DTXSID5045091 Css NA 0.2281 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045091 Css NA 1.258 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045091 Css NA 0.1511 mg/L PBTK NA 50% Rat Human -DTXSID5045091 Css NA 0.805 mg/L PBTK NA 95% Rat Human -DTXSID5045093 Clint NA 0.6044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045093 Fup NA 0.2084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045093 Vd NA 0.6249 L/kg 1compartment NA NA Human Human -DTXSID5045093 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5045093 TK.Half.Life NA 9.946 hours 1compartment NA NA Human Human -DTXSID5045093 Css NA 1.876 mg/L 3compartmentss NA 50% Human Human -DTXSID5045093 Css NA 7.447 mg/L 3compartmentss NA 95% Human Human -DTXSID5045093 Css NA 1.277 mg/L PBTK NA 50% Human Human -DTXSID5045093 Css NA 4.65 mg/L PBTK NA 95% Human Human -DTXSID5045093 Clint NA 0.6044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045093 Fup NA 0.2084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045093 Vd NA 0.5626 L/kg 1compartment NA NA Rat Human +DTXSID5045043 TK.Half.Life NA 4.79 hours 1compartment NA NA Rat Human +DTXSID5045043 Css NA 0.1058 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045043 Css NA 0.4773 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045043 Css NA 0.08871 mg/L PBTK NA 50% Rat Human +DTXSID5045043 Css NA 0.4001 mg/L PBTK NA 95% Rat Human +DTXSID5045091 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045091 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045091 Vd NA 2.911 L/kg 1compartment NA NA Human Human +DTXSID5045091 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5045091 TK.Half.Life NA 27.3 hours 1compartment NA NA Human Human +DTXSID5045091 Css NA 1.15 mg/L 3compartmentss NA 50% Human Human +DTXSID5045091 Css NA 8.363 mg/L 3compartmentss NA 95% Human Human +DTXSID5045091 Css NA 0.7914 mg/L PBTK NA 50% Human Human +DTXSID5045091 Css NA 5.536 mg/L PBTK NA 95% Human Human +DTXSID5045091 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045091 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045091 Vd NA 2.209 L/kg 1compartment NA NA Rat Human +DTXSID5045091 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5045091 TK.Half.Life NA 5.488 hours 1compartment NA NA Rat Human +DTXSID5045091 Css NA 0.1502 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045091 Css NA 0.91 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045091 Css NA 0.1023 mg/L PBTK NA 50% Rat Human +DTXSID5045091 Css NA 0.6076 mg/L PBTK NA 95% Rat Human +DTXSID5045093 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045093 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045093 Vd NA 0.9778 L/kg 1compartment NA NA Human Human +DTXSID5045093 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5045093 TK.Half.Life NA 1.388 hours 1compartment NA NA Human Human +DTXSID5045093 Css NA 0.08056 mg/L 3compartmentss NA 50% Human Human +DTXSID5045093 Css NA 0.5939 mg/L 3compartmentss NA 95% Human Human +DTXSID5045093 Css NA 0.05794 mg/L PBTK NA 50% Human Human +DTXSID5045093 Css NA 0.3948 mg/L PBTK NA 95% Human Human +DTXSID5045093 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045093 Fup 0.263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045093 Vd NA 0.8343 L/kg 1compartment NA NA Rat Human DTXSID5045093 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045093 TK.Half.Life NA 4.021 hours 1compartment NA NA Rat Human -DTXSID5045093 Css NA 0.7173 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045093 Css NA 2.314 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045093 Css NA 0.4606 mg/L PBTK NA 50% Rat Human -DTXSID5045093 Css NA 1.339 mg/L PBTK NA 95% Rat Human -DTXSID5045099 Clint NA 2.104 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045099 Fup NA 0.5134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045099 Vd NA 3.068 L/kg 1compartment NA NA Human Human +DTXSID5045093 TK.Half.Life NA 0.6205 hours 1compartment NA NA Rat Human +DTXSID5045093 Css NA 0.01006 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045093 Css NA 0.0564 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045093 Css NA 0.007161 mg/L PBTK NA 50% Rat Human +DTXSID5045093 Css NA 0.03708 mg/L PBTK NA 95% Rat Human +DTXSID5045099 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045099 Fup 0.486 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045099 Vd NA 1.773 L/kg 1compartment NA NA Human Human DTXSID5045099 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045099 TK.Half.Life NA 9.233 hours 1compartment NA NA Human Human -DTXSID5045099 Css NA 0.2106 mg/L 3compartmentss NA 50% Human Human -DTXSID5045099 Css NA 1.673 mg/L 3compartmentss NA 95% Human Human -DTXSID5045099 Css NA 0.2448 mg/L PBTK NA 50% Human Human -DTXSID5045099 Css NA 1.325 mg/L PBTK NA 95% Human Human -DTXSID5045099 Clint NA 2.104 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045099 Fup NA 0.5134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045099 Vd NA 3.115 L/kg 1compartment NA NA Rat Human +DTXSID5045099 TK.Half.Life NA 2.906 hours 1compartment NA NA Human Human +DTXSID5045099 Css NA 0.1099 mg/L 3compartmentss NA 50% Human Human +DTXSID5045099 Css NA 0.8961 mg/L 3compartmentss NA 95% Human Human +DTXSID5045099 Css NA 0.1027 mg/L PBTK NA 50% Human Human +DTXSID5045099 Css NA 0.66 mg/L PBTK NA 95% Human Human +DTXSID5045099 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045099 Fup 0.486 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045099 Vd NA 1.788 L/kg 1compartment NA NA Rat Human DTXSID5045099 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045099 TK.Half.Life NA 5.1 hours 1compartment NA NA Rat Human -DTXSID5045099 Css NA 0.09012 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045099 Css NA 0.6512 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045099 Css NA 0.1056 mg/L PBTK NA 50% Rat Human -DTXSID5045099 Css NA 0.4622 mg/L PBTK NA 95% Rat Human -DTXSID5045120 Clint NA 0.1235 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045120 Fup NA 0.9505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045120 Vd NA 1.946 L/kg 1compartment NA NA Human Human +DTXSID5045099 TK.Half.Life NA 1.649 hours 1compartment NA NA Rat Human +DTXSID5045099 Css NA 0.01228 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045099 Css NA 0.0833 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045099 Css NA 0.01172 mg/L PBTK NA 50% Rat Human +DTXSID5045099 Css NA 0.05843 mg/L PBTK NA 95% Rat Human +DTXSID5045120 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045120 Fup 0.802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045120 Vd NA 1.82 L/kg 1compartment NA NA Human Human DTXSID5045120 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5045120 TK.Half.Life NA 11.03 hours 1compartment NA NA Human Human -DTXSID5045120 Css NA 0.6066 mg/L 3compartmentss NA 50% Human Human -DTXSID5045120 Css NA 3.702 mg/L 3compartmentss NA 95% Human Human -DTXSID5045120 Css NA 0.6063 mg/L PBTK NA 50% Human Human -DTXSID5045120 Css NA 2.596 mg/L PBTK NA 95% Human Human -DTXSID5045120 Clint NA 0.1235 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045120 Fup NA 0.9505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045120 Vd NA 1.984 L/kg 1compartment NA NA Rat Human +DTXSID5045120 TK.Half.Life NA 14.69 hours 1compartment NA NA Human Human +DTXSID5045120 Css NA 0.7173 mg/L 3compartmentss NA 50% Human Human +DTXSID5045120 Css NA 4.671 mg/L 3compartmentss NA 95% Human Human +DTXSID5045120 Css NA 0.7067 mg/L PBTK NA 50% Human Human +DTXSID5045120 Css NA 3.26 mg/L PBTK NA 95% Human Human +DTXSID5045120 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045120 Fup 0.802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045120 Vd NA 1.85 L/kg 1compartment NA NA Rat Human DTXSID5045120 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045120 TK.Half.Life NA 4.191 hours 1compartment NA NA Rat Human -DTXSID5045120 Css NA 0.1672 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045120 Css NA 1.074 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045120 Css NA 0.1669 mg/L PBTK NA 50% Rat Human -DTXSID5045120 Css NA 0.6965 mg/L PBTK NA 95% Rat Human -DTXSID5045122 Clint NA 56.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045122 Fup NA 0.1107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045122 Vd NA 1.146 L/kg 1compartment NA NA Human Human +DTXSID5045120 TK.Half.Life NA 5.085 hours 1compartment NA NA Rat Human +DTXSID5045120 Css NA 0.01774 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045120 Css NA 0.144 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045120 Css NA 0.01724 mg/L PBTK NA 50% Rat Human +DTXSID5045120 Css NA 0.1001 mg/L PBTK NA 95% Rat Human +DTXSID5045122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045122 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045122 Vd NA 2.363 L/kg 1compartment NA NA Human Human DTXSID5045122 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045122 TK.Half.Life NA 1.606 hours 1compartment NA NA Human Human -DTXSID5045122 Css NA 0.09426 mg/L 3compartmentss NA 50% Human Human -DTXSID5045122 Css NA 0.8121 mg/L 3compartmentss NA 95% Human Human -DTXSID5045122 Css NA 0.0646 mg/L PBTK NA 50% Human Human -DTXSID5045122 Css NA 0.5232 mg/L PBTK NA 95% Human Human -DTXSID5045122 Clint NA 56.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045122 Fup NA 0.1107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045122 Vd NA 1.067 L/kg 1compartment NA NA Rat Human +DTXSID5045122 TK.Half.Life NA 2.784 hours 1compartment NA NA Human Human +DTXSID5045122 Css NA 0.05616 mg/L 3compartmentss NA 50% Human Human +DTXSID5045122 Css NA 0.4432 mg/L 3compartmentss NA 95% Human Human +DTXSID5045122 Css NA 0.05046 mg/L PBTK NA 50% Human Human +DTXSID5045122 Css NA 0.353 mg/L PBTK NA 95% Human Human +DTXSID5045122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045122 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045122 Vd NA 2.214 L/kg 1compartment NA NA Rat Human DTXSID5045122 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045122 TK.Half.Life NA 0.8003 hours 1compartment NA NA Rat Human -DTXSID5045122 Css NA 0.05309 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045122 Css NA 0.3704 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045122 Css NA 0.03464 mg/L PBTK NA 50% Rat Human -DTXSID5045122 Css NA 0.219 mg/L PBTK NA 95% Rat Human -DTXSID5045124 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045124 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045124 Vd NA 0.7431 L/kg 1compartment NA NA Human Human -DTXSID5045124 Days.Css NA 54 Days PBTK NA NA Human Human -DTXSID5045124 TK.Half.Life NA 228.8 hours 1compartment NA NA Human Human -DTXSID5045124 Css NA 49.42 mg/L 3compartmentss NA 50% Human Human -DTXSID5045124 Css NA 297.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5045124 Css NA 30.97 mg/L PBTK NA 50% Human Human -DTXSID5045124 Css NA 175.9 mg/L PBTK NA 95% Human Human -DTXSID5045124 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045124 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045124 Vd NA 0.5821 L/kg 1compartment NA NA Rat Human -DTXSID5045124 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID5045124 TK.Half.Life NA 57.43 hours 1compartment NA NA Rat Human -DTXSID5045124 Css NA 14.08 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045124 Css NA 72.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045124 Css NA 8.222 mg/L PBTK NA 50% Rat Human -DTXSID5045124 Css NA 39.6 mg/L PBTK NA 95% Rat Human -DTXSID5045128 Clint NA 23.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045128 Fup NA 0.4043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045128 Vd NA 0.6472 L/kg 1compartment NA NA Human Human +DTXSID5045122 TK.Half.Life NA 1.331 hours 1compartment NA NA Rat Human +DTXSID5045122 Css NA 0.007012 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045122 Css NA 0.04268 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045122 Css NA 0.00648 mg/L PBTK NA 50% Rat Human +DTXSID5045122 Css NA 0.03379 mg/L PBTK NA 95% Rat Human +DTXSID5045124 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045124 Fup 0.0148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045124 Vd NA 1.039 L/kg 1compartment NA NA Human Human +DTXSID5045124 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5045124 TK.Half.Life NA 11.59 hours 1compartment NA NA Human Human +DTXSID5045124 Css NA 1.771 mg/L 3compartmentss NA 50% Human Human +DTXSID5045124 Css NA 17.59 mg/L 3compartmentss NA 95% Human Human +DTXSID5045124 Css NA 1.108 mg/L PBTK NA 50% Human Human +DTXSID5045124 Css NA 10.42 mg/L PBTK NA 95% Human Human +DTXSID5045124 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045124 Fup 0.0148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045124 Vd NA 0.7859 L/kg 1compartment NA NA Rat Human +DTXSID5045124 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5045124 TK.Half.Life NA 5.177 hours 1compartment NA NA Rat Human +DTXSID5045124 Css NA 0.2389 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045124 Css NA 1.825 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045124 Css NA 0.1448 mg/L PBTK NA 50% Rat Human +DTXSID5045124 Css NA 1.059 mg/L PBTK NA 95% Rat Human +DTXSID5045128 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045128 Fup 0.51 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045128 Vd NA 0.8069 L/kg 1compartment NA NA Human Human DTXSID5045128 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045128 TK.Half.Life NA 0.7096 hours 1compartment NA NA Human Human -DTXSID5045128 Css NA 0.04858 mg/L 3compartmentss NA 50% Human Human -DTXSID5045128 Css NA 0.3743 mg/L 3compartmentss NA 95% Human Human -DTXSID5045128 Css NA 0.03615 mg/L PBTK NA 50% Human Human -DTXSID5045128 Css NA 0.2556 mg/L PBTK NA 95% Human Human -DTXSID5045128 Clint NA 23.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045128 Fup NA 0.4043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045128 Vd NA 0.6384 L/kg 1compartment NA NA Rat Human +DTXSID5045128 TK.Half.Life NA 1.358 hours 1compartment NA NA Human Human +DTXSID5045128 Css NA 0.1247 mg/L 3compartmentss NA 50% Human Human +DTXSID5045128 Css NA 0.9684 mg/L 3compartmentss NA 95% Human Human +DTXSID5045128 Css NA 0.09816 mg/L PBTK NA 50% Human Human +DTXSID5045128 Css NA 0.6626 mg/L PBTK NA 95% Human Human +DTXSID5045128 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045128 Fup 0.51 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045128 Vd NA 0.7838 L/kg 1compartment NA NA Rat Human DTXSID5045128 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045128 TK.Half.Life NA 0.3582 hours 1compartment NA NA Rat Human -DTXSID5045128 Css NA 0.02626 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045128 Css NA 0.161 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045128 Css NA 0.01881 mg/L PBTK NA 50% Rat Human -DTXSID5045128 Css NA 0.1034 mg/L PBTK NA 95% Rat Human +DTXSID5045128 TK.Half.Life NA 0.7196 hours 1compartment NA NA Rat Human +DTXSID5045128 Css NA 0.01433 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045128 Css NA 0.08794 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045128 Css NA 0.01137 mg/L PBTK NA 50% Rat Human +DTXSID5045128 Css NA 0.05681 mg/L PBTK NA 95% Rat Human DTXSID5045170 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5045170 Fup 0.93 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5045170 Vd NA 1.087 L/kg 1compartment NA NA Human Human DTXSID5045170 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5045170 TK.Half.Life NA 1.686 hours 1compartment NA NA Human Human -DTXSID5045170 Css NA 0.1386 mg/L 3compartmentss NA 50% Human Human -DTXSID5045170 Css NA 0.7038 mg/L 3compartmentss NA 95% Human Human -DTXSID5045170 Css NA 0.1242 mg/L PBTK NA 50% Human Human -DTXSID5045170 Css NA 0.55 mg/L PBTK NA 95% Human Human +DTXSID5045170 Css NA 0.1338 mg/L 3compartmentss NA 50% Human Human +DTXSID5045170 Css NA 0.7136 mg/L 3compartmentss NA 95% Human Human +DTXSID5045170 Css NA 0.1187 mg/L PBTK NA 50% Human Human +DTXSID5045170 Css NA 0.5514 mg/L PBTK NA 95% Human Human DTXSID5045170 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5045170 Fup 0.93 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5045170 Vd NA 1.065 L/kg 1compartment NA NA Rat Human DTXSID5045170 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5045170 TK.Half.Life NA 0.864 hours 1compartment NA NA Rat Human -DTXSID5045170 Css NA 0.06124 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045170 Css NA 0.2505 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045170 Css NA 0.05491 mg/L PBTK NA 50% Rat Human -DTXSID5045170 Css NA 0.1797 mg/L PBTK NA 95% Rat Human -DTXSID5045174 Clint NA 27.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045174 Fup NA 0.2813 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045174 Vd NA 2.798 L/kg 1compartment NA NA Human Human +DTXSID5045170 Css NA 0.01387 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045170 Css NA 0.0575 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045170 Css NA 0.01282 mg/L PBTK NA 50% Rat Human +DTXSID5045170 Css NA 0.04205 mg/L PBTK NA 95% Rat Human +DTXSID5045172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045172 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5045172 Vd NA 2.221 L/kg 1compartment NA NA Human Human +DTXSID5045172 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5045172 TK.Half.Life NA 5.023 hours 1compartment NA NA Human Human +DTXSID5045172 Css NA 0.2126 mg/L 3compartmentss NA 50% Human Human +DTXSID5045172 Css NA 1.835 mg/L 3compartmentss NA 95% Human Human +DTXSID5045172 Css NA 0.1674 mg/L PBTK NA 50% Human Human +DTXSID5045172 Css NA 1.28 mg/L PBTK NA 95% Human Human +DTXSID5045172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045172 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5045172 Vd NA 2.134 L/kg 1compartment NA NA Rat Human +DTXSID5045172 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5045172 TK.Half.Life NA 2.794 hours 1compartment NA NA Rat Human +DTXSID5045172 Css NA 0.02724 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045172 Css NA 0.1812 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045172 Css NA 0.02133 mg/L PBTK NA 50% Rat Human +DTXSID5045172 Css NA 0.1247 mg/L PBTK NA 95% Rat Human +DTXSID5045174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045174 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045174 Vd NA 3.66 L/kg 1compartment NA NA Human Human DTXSID5045174 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045174 TK.Half.Life NA 2.245 hours 1compartment NA NA Human Human -DTXSID5045174 Css NA 0.02721 mg/L 3compartmentss NA 50% Human Human -DTXSID5045174 Css NA 0.2477 mg/L 3compartmentss NA 95% Human Human -DTXSID5045174 Css NA 0.03231 mg/L PBTK NA 50% Human Human -DTXSID5045174 Css NA 0.2252 mg/L PBTK NA 95% Human Human -DTXSID5045174 Clint NA 27.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045174 Fup NA 0.2813 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045174 Vd NA 2.767 L/kg 1compartment NA NA Rat Human +DTXSID5045174 TK.Half.Life NA 2.428 hours 1compartment NA NA Human Human +DTXSID5045174 Css NA 0.01826 mg/L 3compartmentss NA 50% Human Human +DTXSID5045174 Css NA 0.1875 mg/L 3compartmentss NA 95% Human Human +DTXSID5045174 Css NA 0.02603 mg/L PBTK NA 50% Human Human +DTXSID5045174 Css NA 0.1943 mg/L PBTK NA 95% Human Human +DTXSID5045174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045174 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045174 Vd NA 3.634 L/kg 1compartment NA NA Rat Human DTXSID5045174 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045174 TK.Half.Life NA 1.204 hours 1compartment NA NA Rat Human -DTXSID5045174 Css NA 0.01442 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045174 Css NA 0.1036 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045174 Css NA 0.0169 mg/L PBTK NA 50% Rat Human -DTXSID5045174 Css NA 0.0926 mg/L PBTK NA 95% Rat Human -DTXSID5045176 Clint NA 141.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5045174 TK.Half.Life NA 1.309 hours 1compartment NA NA Rat Human +DTXSID5045174 Css NA 0.002177 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045174 Css NA 0.01816 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045174 Css NA 0.003294 mg/L PBTK NA 50% Rat Human +DTXSID5045174 Css NA 0.01856 mg/L PBTK NA 95% Rat Human +DTXSID5045176 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5045176 Fup 0.008 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5045176 Vd NA 0.7203 L/kg 1compartment NA NA Human Human -DTXSID5045176 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045176 TK.Half.Life NA 2.165 hours 1compartment NA NA Human Human -DTXSID5045176 Css NA 0.3832 mg/L 3compartmentss NA 50% Human Human -DTXSID5045176 Css NA 4.088 mg/L 3compartmentss NA 95% Human Human -DTXSID5045176 Css NA 0.233 mg/L PBTK NA 50% Human Human -DTXSID5045176 Css NA 2.4 mg/L PBTK NA 95% Human Human -DTXSID5045176 Clint NA 141.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5045176 Vd NA 0.7421 L/kg 1compartment NA NA Human Human +DTXSID5045176 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5045176 TK.Half.Life NA 10.38 hours 1compartment NA NA Human Human +DTXSID5045176 Css NA 2.339 mg/L 3compartmentss NA 50% Human Human +DTXSID5045176 Css NA 25.07 mg/L 3compartmentss NA 95% Human Human +DTXSID5045176 Css NA 1.435 mg/L PBTK NA 50% Human Human +DTXSID5045176 Css NA 14.9 mg/L PBTK NA 95% Human Human +DTXSID5045176 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5045176 Fup 0.008 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5045176 Vd NA 0.6223 L/kg 1compartment NA NA Rat Human +DTXSID5045176 Vd NA 0.6389 L/kg 1compartment NA NA Rat Human DTXSID5045176 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045176 TK.Half.Life NA 1.131 hours 1compartment NA NA Rat Human -DTXSID5045176 Css NA 0.2235 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045176 Css NA 1.982 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045176 Css NA 0.127 mg/L PBTK NA 50% Rat Human -DTXSID5045176 Css NA 1.086 mg/L PBTK NA 95% Rat Human -DTXSID5045178 Clint NA 0.299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045178 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045178 Vd NA 1.212 L/kg 1compartment NA NA Human Human -DTXSID5045178 Days.Css NA 45 Days PBTK NA NA Human Human -DTXSID5045178 TK.Half.Life NA 205.9 hours 1compartment NA NA Human Human -DTXSID5045178 Css NA 26.98 mg/L 3compartmentss NA 50% Human Human -DTXSID5045178 Css NA 153.2 mg/L 3compartmentss NA 95% Human Human -DTXSID5045178 Css NA 16.81 mg/L PBTK NA 50% Human Human -DTXSID5045178 Css NA 88.69 mg/L PBTK NA 95% Human Human -DTXSID5045178 Clint NA 0.299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045178 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045178 Vd NA 0.9053 L/kg 1compartment NA NA Rat Human -DTXSID5045178 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID5045178 TK.Half.Life NA 55.27 hours 1compartment NA NA Rat Human -DTXSID5045178 Css NA 9.602 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045178 Css NA 46.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045178 Css NA 5.586 mg/L PBTK NA 50% Rat Human -DTXSID5045178 Css NA 25.64 mg/L PBTK NA 95% Rat Human -DTXSID5045201 Clint NA 7.761 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045201 Fup NA 0.6186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045201 Vd NA 1.303 L/kg 1compartment NA NA Human Human +DTXSID5045176 TK.Half.Life NA 5.839 hours 1compartment NA NA Rat Human +DTXSID5045176 Css NA 0.3142 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045176 Css NA 2.626 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045176 Css NA 0.1851 mg/L PBTK NA 50% Rat Human +DTXSID5045176 Css NA 1.505 mg/L PBTK NA 95% Rat Human +DTXSID5045178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045178 Fup 0.00358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045178 Vd NA 3.019 L/kg 1compartment NA NA Human Human +DTXSID5045178 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID5045178 TK.Half.Life NA 91.26 hours 1compartment NA NA Human Human +DTXSID5045178 Css NA 3.663 mg/L 3compartmentss NA 50% Human Human +DTXSID5045178 Css NA 24.1 mg/L 3compartmentss NA 95% Human Human +DTXSID5045178 Css NA 2.526 mg/L PBTK NA 50% Human Human +DTXSID5045178 Css NA 16.05 mg/L PBTK NA 95% Human Human +DTXSID5045178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045178 Fup 0.00358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045178 Vd NA 2.259 L/kg 1compartment NA NA Rat Human +DTXSID5045178 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID5045178 TK.Half.Life NA 13.97 hours 1compartment NA NA Rat Human +DTXSID5045178 Css NA 0.4818 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045178 Css NA 2.472 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045178 Css NA 0.327 mg/L PBTK NA 50% Rat Human +DTXSID5045178 Css NA 1.699 mg/L PBTK NA 95% Rat Human +DTXSID5045201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045201 Fup 0.522 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045201 Vd NA 1.175 L/kg 1compartment NA NA Human Human DTXSID5045201 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045201 TK.Half.Life NA 1.734 hours 1compartment NA NA Human Human -DTXSID5045201 Css NA 0.09076 mg/L 3compartmentss NA 50% Human Human -DTXSID5045201 Css NA 0.8619 mg/L 3compartmentss NA 95% Human Human -DTXSID5045201 Css NA 0.07805 mg/L PBTK NA 50% Human Human -DTXSID5045201 Css NA 0.5889 mg/L PBTK NA 95% Human Human -DTXSID5045201 Clint NA 7.761 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045201 Fup NA 0.6186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045201 Vd NA 1.168 L/kg 1compartment NA NA Rat Human +DTXSID5045201 TK.Half.Life NA 1.125 hours 1compartment NA NA Human Human +DTXSID5045201 Css NA 0.0372 mg/L 3compartmentss NA 50% Human Human +DTXSID5045201 Css NA 0.3419 mg/L 3compartmentss NA 95% Human Human +DTXSID5045201 Css NA 0.03056 mg/L PBTK NA 50% Human Human +DTXSID5045201 Css NA 0.2387 mg/L PBTK NA 95% Human Human +DTXSID5045201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045201 Fup 0.522 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045201 Vd NA 1.052 L/kg 1compartment NA NA Rat Human DTXSID5045201 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045201 TK.Half.Life NA 0.8016 hours 1compartment NA NA Rat Human -DTXSID5045201 Css NA 0.04467 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045201 Css NA 0.3631 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045201 Css NA 0.03782 mg/L PBTK NA 50% Rat Human -DTXSID5045201 Css NA 0.2273 mg/L PBTK NA 95% Rat Human -DTXSID5045203 Clint NA 721.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045203 Fup NA 0.4396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045203 Vd NA 0.5854 L/kg 1compartment NA NA Human Human +DTXSID5045201 TK.Half.Life NA 0.4983 hours 1compartment NA NA Rat Human +DTXSID5045201 Css NA 0.004455 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045201 Css NA 0.0359 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045201 Css NA 0.003723 mg/L PBTK NA 50% Rat Human +DTXSID5045201 Css NA 0.02461 mg/L PBTK NA 95% Rat Human +DTXSID5045203 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045203 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045203 Vd NA 0.4725 L/kg 1compartment NA NA Human Human DTXSID5045203 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045203 TK.Half.Life NA 0.4297 hours 1compartment NA NA Human Human -DTXSID5045203 Css NA 0.00151 mg/L 3compartmentss NA 50% Human Human -DTXSID5045203 Css NA 0.01323 mg/L 3compartmentss NA 95% Human Human -DTXSID5045203 Css NA 0.001123 mg/L PBTK NA 50% Human Human -DTXSID5045203 Css NA 0.008795 mg/L PBTK NA 95% Human Human -DTXSID5045203 Clint NA 721.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045203 Fup NA 0.4396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045203 Vd NA 0.5584 L/kg 1compartment NA NA Rat Human +DTXSID5045203 TK.Half.Life NA 0.5536 hours 1compartment NA NA Human Human +DTXSID5045203 Css NA 0.04359 mg/L 3compartmentss NA 50% Human Human +DTXSID5045203 Css NA 0.3561 mg/L 3compartmentss NA 95% Human Human +DTXSID5045203 Css NA 0.03084 mg/L PBTK NA 50% Human Human +DTXSID5045203 Css NA 0.2305 mg/L PBTK NA 95% Human Human +DTXSID5045203 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045203 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045203 Vd NA 0.4624 L/kg 1compartment NA NA Rat Human DTXSID5045203 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045203 TK.Half.Life NA 0.1788 hours 1compartment NA NA Rat Human -DTXSID5045203 Css NA 0.0008144 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045203 Css NA 0.006122 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045203 Css NA 0.0005786 mg/L PBTK NA 50% Rat Human -DTXSID5045203 Css NA 0.003895 mg/L PBTK NA 95% Rat Human -DTXSID5045205 Clint NA 29.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045205 Fup NA 0.1792 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045205 Vd NA 1.894 L/kg 1compartment NA NA Human Human +DTXSID5045203 TK.Half.Life NA 0.2779 hours 1compartment NA NA Rat Human +DTXSID5045203 Css NA 0.002064 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045203 Css NA 0.01868 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045203 Css NA 0.001442 mg/L PBTK NA 50% Rat Human +DTXSID5045203 Css NA 0.01182 mg/L PBTK NA 95% Rat Human +DTXSID5045205 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045205 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045205 Vd NA 1.497 L/kg 1compartment NA NA Human Human DTXSID5045205 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045205 TK.Half.Life NA 3.358 hours 1compartment NA NA Human Human -DTXSID5045205 Css NA 0.1261 mg/L 3compartmentss NA 50% Human Human -DTXSID5045205 Css NA 0.8327 mg/L 3compartmentss NA 95% Human Human -DTXSID5045205 Css NA 0.09016 mg/L PBTK NA 50% Human Human -DTXSID5045205 Css NA 0.5626 mg/L PBTK NA 95% Human Human -DTXSID5045205 Clint NA 29.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045205 Fup NA 0.1792 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045205 Vd NA 1.455 L/kg 1compartment NA NA Rat Human +DTXSID5045205 TK.Half.Life NA 10.99 hours 1compartment NA NA Human Human +DTXSID5045205 Css NA 0.9821 mg/L 3compartmentss NA 50% Human Human +DTXSID5045205 Css NA 6.475 mg/L 3compartmentss NA 95% Human Human +DTXSID5045205 Css NA 0.6517 mg/L PBTK NA 50% Human Human +DTXSID5045205 Css NA 4.027 mg/L PBTK NA 95% Human Human +DTXSID5045205 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045205 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045205 Vd NA 1.143 L/kg 1compartment NA NA Rat Human DTXSID5045205 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045205 TK.Half.Life NA 1.167 hours 1compartment NA NA Rat Human -DTXSID5045205 Css NA 0.06932 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045205 Css NA 0.3524 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045205 Css NA 0.04719 mg/L PBTK NA 50% Rat Human -DTXSID5045205 Css NA 0.2298 mg/L PBTK NA 95% Rat Human -DTXSID5045209 Clint NA 5.857 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045209 Fup NA 0.3565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045209 Vd NA 1.428 L/kg 1compartment NA NA Human Human +DTXSID5045205 TK.Half.Life NA 4.183 hours 1compartment NA NA Rat Human +DTXSID5045205 Css NA 0.1216 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045205 Css NA 0.5801 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045205 Css NA 0.07882 mg/L PBTK NA 50% Rat Human +DTXSID5045205 Css NA 0.3499 mg/L PBTK NA 95% Rat Human +DTXSID5045209 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045209 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045209 Vd NA 1.384 L/kg 1compartment NA NA Human Human DTXSID5045209 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045209 TK.Half.Life NA 3.635 hours 1compartment NA NA Human Human -DTXSID5045209 Css NA 0.2194 mg/L 3compartmentss NA 50% Human Human -DTXSID5045209 Css NA 1.39 mg/L 3compartmentss NA 95% Human Human -DTXSID5045209 Css NA 0.1699 mg/L PBTK NA 50% Human Human -DTXSID5045209 Css NA 0.9485 mg/L PBTK NA 95% Human Human -DTXSID5045209 Clint NA 5.857 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045209 Fup NA 0.3565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045209 Vd NA 1.178 L/kg 1compartment NA NA Rat Human +DTXSID5045209 TK.Half.Life NA 6.782 hours 1compartment NA NA Human Human +DTXSID5045209 Css NA 0.5692 mg/L 3compartmentss NA 50% Human Human +DTXSID5045209 Css NA 3.623 mg/L 3compartmentss NA 95% Human Human +DTXSID5045209 Css NA 0.3892 mg/L PBTK NA 50% Human Human +DTXSID5045209 Css NA 2.313 mg/L PBTK NA 95% Human Human +DTXSID5045209 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045209 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045209 Vd NA 1.084 L/kg 1compartment NA NA Rat Human DTXSID5045209 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045209 TK.Half.Life NA 1.522 hours 1compartment NA NA Rat Human -DTXSID5045209 Css NA 0.1114 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045209 Css NA 0.4977 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045209 Css NA 0.08385 mg/L PBTK NA 50% Rat Human -DTXSID5045209 Css NA 0.3309 mg/L PBTK NA 95% Rat Human -DTXSID5045330 Clint NA 53.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045330 Fup NA 0.3739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045330 Vd NA 1.053 L/kg 1compartment NA NA Human Human +DTXSID5045209 TK.Half.Life NA 2.738 hours 1compartment NA NA Rat Human +DTXSID5045209 Css NA 0.06879 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045209 Css NA 0.3191 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045209 Css NA 0.04654 mg/L PBTK NA 50% Rat Human +DTXSID5045209 Css NA 0.197 mg/L PBTK NA 95% Rat Human +DTXSID5045330 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045330 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045330 Vd NA 0.8592 L/kg 1compartment NA NA Human Human DTXSID5045330 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045330 TK.Half.Life NA 0.9372 hours 1compartment NA NA Human Human -DTXSID5045330 Css NA 0.02344 mg/L 3compartmentss NA 50% Human Human -DTXSID5045330 Css NA 0.1841 mg/L 3compartmentss NA 95% Human Human -DTXSID5045330 Css NA 0.01818 mg/L PBTK NA 50% Human Human -DTXSID5045330 Css NA 0.1278 mg/L PBTK NA 95% Human Human -DTXSID5045330 Clint NA 53.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045330 Fup NA 0.3739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045330 Vd NA 0.9179 L/kg 1compartment NA NA Rat Human +DTXSID5045330 TK.Half.Life NA 2.907 hours 1compartment NA NA Human Human +DTXSID5045330 Css NA 0.2859 mg/L 3compartmentss NA 50% Human Human +DTXSID5045330 Css NA 1.734 mg/L 3compartmentss NA 95% Human Human +DTXSID5045330 Css NA 0.1986 mg/L PBTK NA 50% Human Human +DTXSID5045330 Css NA 1.142 mg/L PBTK NA 95% Human Human +DTXSID5045330 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045330 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045330 Vd NA 0.7316 L/kg 1compartment NA NA Rat Human DTXSID5045330 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045330 TK.Half.Life NA 0.3888 hours 1compartment NA NA Rat Human -DTXSID5045330 Css NA 0.01265 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045330 Css NA 0.08401 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045330 Css NA 0.009382 mg/L PBTK NA 50% Rat Human -DTXSID5045330 Css NA 0.05639 mg/L PBTK NA 95% Rat Human -DTXSID5045332 Clint NA 54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045332 Fup NA 0.0451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045332 Vd NA 2.741 L/kg 1compartment NA NA Human Human +DTXSID5045330 TK.Half.Life NA 1.397 hours 1compartment NA NA Rat Human +DTXSID5045330 Css NA 0.01283 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045330 Css NA 0.09029 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045330 Css NA 0.008956 mg/L PBTK NA 50% Rat Human +DTXSID5045330 Css NA 0.05704 mg/L PBTK NA 95% Rat Human +DTXSID5045332 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045332 Fup 0.0763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045332 Vd NA 2.745 L/kg 1compartment NA NA Human Human DTXSID5045332 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045332 TK.Half.Life NA 10.07 hours 1compartment NA NA Human Human -DTXSID5045332 Css NA 0.4047 mg/L 3compartmentss NA 50% Human Human -DTXSID5045332 Css NA 2.636 mg/L 3compartmentss NA 95% Human Human -DTXSID5045332 Css NA 0.2804 mg/L PBTK NA 50% Human Human -DTXSID5045332 Css NA 1.745 mg/L PBTK NA 95% Human Human -DTXSID5045332 Clint NA 54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045332 Fup NA 0.0451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045332 Vd NA 2.116 L/kg 1compartment NA NA Rat Human +DTXSID5045332 TK.Half.Life NA 13.96 hours 1compartment NA NA Human Human +DTXSID5045332 Css NA 0.5752 mg/L 3compartmentss NA 50% Human Human +DTXSID5045332 Css NA 3.759 mg/L 3compartmentss NA 95% Human Human +DTXSID5045332 Css NA 0.4111 mg/L PBTK NA 50% Human Human +DTXSID5045332 Css NA 2.577 mg/L PBTK NA 95% Human Human +DTXSID5045332 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045332 Fup 0.0763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045332 Vd NA 2.165 L/kg 1compartment NA NA Rat Human DTXSID5045332 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045332 TK.Half.Life NA 2.66 hours 1compartment NA NA Rat Human -DTXSID5045332 Css NA 0.2273 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045332 Css NA 1.253 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045332 Css NA 0.1506 mg/L PBTK NA 50% Rat Human -DTXSID5045332 Css NA 0.788 mg/L PBTK NA 95% Rat Human -DTXSID5045380 Clint NA 90.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045380 Fup NA 0.365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045380 Vd NA 0.3347 L/kg 1compartment NA NA Human Human +DTXSID5045332 TK.Half.Life NA 3.898 hours 1compartment NA NA Rat Human +DTXSID5045332 Css NA 0.07364 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045332 Css NA 0.3957 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045332 Css NA 0.05227 mg/L PBTK NA 50% Rat Human +DTXSID5045332 Css NA 0.2656 mg/L PBTK NA 95% Rat Human +DTXSID5045380 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045380 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045380 Vd NA 0.6648 L/kg 1compartment NA NA Human Human DTXSID5045380 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045380 TK.Half.Life NA 0.307 hours 1compartment NA NA Human Human -DTXSID5045380 Css NA 0.01543 mg/L 3compartmentss NA 50% Human Human -DTXSID5045380 Css NA 0.1202 mg/L 3compartmentss NA 95% Human Human -DTXSID5045380 Css NA 0.01027 mg/L PBTK NA 50% Human Human -DTXSID5045380 Css NA 0.07658 mg/L PBTK NA 95% Human Human -DTXSID5045380 Clint NA 90.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045380 Fup NA 0.365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045380 Vd NA 0.3428 L/kg 1compartment NA NA Rat Human +DTXSID5045380 TK.Half.Life NA 6.856 hours 1compartment NA NA Human Human +DTXSID5045380 Css NA 1.158 mg/L 3compartmentss NA 50% Human Human +DTXSID5045380 Css NA 7.512 mg/L 3compartmentss NA 95% Human Human +DTXSID5045380 Css NA 0.9317 mg/L PBTK NA 50% Human Human +DTXSID5045380 Css NA 4.838 mg/L PBTK NA 95% Human Human +DTXSID5045380 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045380 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045380 Vd NA 0.6854 L/kg 1compartment NA NA Rat Human DTXSID5045380 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045380 TK.Half.Life NA 0.1452 hours 1compartment NA NA Rat Human -DTXSID5045380 Css NA 0.008433 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045380 Css NA 0.05269 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045380 Css NA 0.005364 mg/L PBTK NA 50% Rat Human -DTXSID5045380 Css NA 0.03172 mg/L PBTK NA 95% Rat Human -DTXSID5045382 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045382 Fup NA 0.3899 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045382 Vd NA 0.5006 L/kg 1compartment NA NA Human Human +DTXSID5045380 TK.Half.Life NA 2.41 hours 1compartment NA NA Rat Human +DTXSID5045380 Css NA 0.06991 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045380 Css NA 0.4514 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045380 Css NA 0.05612 mg/L PBTK NA 50% Rat Human +DTXSID5045380 Css NA 0.275 mg/L PBTK NA 95% Rat Human +DTXSID5045382 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045382 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045382 Vd NA 0.3053 L/kg 1compartment NA NA Human Human DTXSID5045382 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045382 TK.Half.Life NA 8.315 hours 1compartment NA NA Human Human -DTXSID5045382 Css NA 1.902 mg/L 3compartmentss NA 50% Human Human -DTXSID5045382 Css NA 8.032 mg/L 3compartmentss NA 95% Human Human -DTXSID5045382 Css NA 1.371 mg/L PBTK NA 50% Human Human -DTXSID5045382 Css NA 5.083 mg/L PBTK NA 95% Human Human -DTXSID5045382 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045382 Fup NA 0.3899 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045382 Vd NA 0.5136 L/kg 1compartment NA NA Rat Human +DTXSID5045382 TK.Half.Life NA 6.022 hours 1compartment NA NA Human Human +DTXSID5045382 Css NA 1.313 mg/L 3compartmentss NA 50% Human Human +DTXSID5045382 Css NA 5.48 mg/L 3compartmentss NA 95% Human Human +DTXSID5045382 Css NA 0.8653 mg/L PBTK NA 50% Human Human +DTXSID5045382 Css NA 3.325 mg/L PBTK NA 95% Human Human +DTXSID5045382 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045382 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045382 Vd NA 0.3145 L/kg 1compartment NA NA Rat Human DTXSID5045382 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045382 TK.Half.Life NA 2.906 hours 1compartment NA NA Rat Human -DTXSID5045382 Css NA 0.5258 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045382 Css NA 1.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045382 Css NA 0.3606 mg/L PBTK NA 50% Rat Human -DTXSID5045382 Css NA 1.104 mg/L PBTK NA 95% Rat Human -DTXSID5045384 Clint NA 10.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045384 Fup NA 0.4232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045384 Vd NA 2.465 L/kg 1compartment NA NA Human Human +DTXSID5045382 TK.Half.Life NA 2.115 hours 1compartment NA NA Rat Human +DTXSID5045382 Css NA 0.007092 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045382 Css NA 0.03073 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045382 Css NA 0.004436 mg/L PBTK NA 50% Rat Human +DTXSID5045382 Css NA 0.01776 mg/L PBTK NA 95% Rat Human +DTXSID5045384 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045384 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045384 Vd NA 2.174 L/kg 1compartment NA NA Human Human DTXSID5045384 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045384 TK.Half.Life NA 3.705 hours 1compartment NA NA Human Human -DTXSID5045384 Css NA 0.09464 mg/L 3compartmentss NA 50% Human Human -DTXSID5045384 Css NA 0.7196 mg/L 3compartmentss NA 95% Human Human -DTXSID5045384 Css NA 0.08745 mg/L PBTK NA 50% Human Human -DTXSID5045384 Css NA 0.5594 mg/L PBTK NA 95% Human Human -DTXSID5045384 Clint NA 10.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045384 Fup NA 0.4232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045384 Vd NA 2.243 L/kg 1compartment NA NA Rat Human +DTXSID5045384 TK.Half.Life NA 4.229 hours 1compartment NA NA Human Human +DTXSID5045384 Css NA 0.1344 mg/L 3compartmentss NA 50% Human Human +DTXSID5045384 Css NA 0.9544 mg/L 3compartmentss NA 95% Human Human +DTXSID5045384 Css NA 0.1248 mg/L PBTK NA 50% Human Human +DTXSID5045384 Css NA 0.7318 mg/L PBTK NA 95% Human Human +DTXSID5045384 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045384 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045384 Vd NA 2.032 L/kg 1compartment NA NA Rat Human DTXSID5045384 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045384 TK.Half.Life NA 1.665 hours 1compartment NA NA Rat Human -DTXSID5045384 Css NA 0.0488 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045384 Css NA 0.2765 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045384 Css NA 0.04441 mg/L PBTK NA 50% Rat Human -DTXSID5045384 Css NA 0.2063 mg/L PBTK NA 95% Rat Human -DTXSID5045386 Clint NA 15.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045386 Fup NA 0.6746 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045386 Vd NA 2.15 L/kg 1compartment NA NA Human Human -DTXSID5045386 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045386 TK.Half.Life NA 1.679 hours 1compartment NA NA Human Human -DTXSID5045386 Css NA 0.03383 mg/L 3compartmentss NA 50% Human Human -DTXSID5045386 Css NA 0.3715 mg/L 3compartmentss NA 95% Human Human -DTXSID5045386 Css NA 0.03615 mg/L PBTK NA 50% Human Human -DTXSID5045386 Css NA 0.291 mg/L PBTK NA 95% Human Human -DTXSID5045386 Clint NA 15.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045386 Fup NA 0.6746 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045386 Vd NA 2.123 L/kg 1compartment NA NA Rat Human +DTXSID5045384 TK.Half.Life NA 2.069 hours 1compartment NA NA Rat Human +DTXSID5045384 Css NA 0.0156 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045384 Css NA 0.08836 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045384 Css NA 0.01456 mg/L PBTK NA 50% Rat Human +DTXSID5045384 Css NA 0.06473 mg/L PBTK NA 95% Rat Human +DTXSID5045386 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045386 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045386 Vd NA 2.046 L/kg 1compartment NA NA Human Human +DTXSID5045386 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5045386 TK.Half.Life NA 22.82 hours 1compartment NA NA Human Human +DTXSID5045386 Css NA 0.8153 mg/L 3compartmentss NA 50% Human Human +DTXSID5045386 Css NA 6.915 mg/L 3compartmentss NA 95% Human Human +DTXSID5045386 Css NA 0.8597 mg/L PBTK NA 50% Human Human +DTXSID5045386 Css NA 4.817 mg/L PBTK NA 95% Human Human +DTXSID5045386 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045386 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045386 Vd NA 2.016 L/kg 1compartment NA NA Rat Human DTXSID5045386 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045386 TK.Half.Life NA 0.8708 hours 1compartment NA NA Rat Human -DTXSID5045386 Css NA 0.0167 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045386 Css NA 0.1776 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045386 Css NA 0.01787 mg/L PBTK NA 50% Rat Human -DTXSID5045386 Css NA 0.1267 mg/L PBTK NA 95% Rat Human -DTXSID5045388 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045388 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045388 Vd NA 0.6105 L/kg 1compartment NA NA Human Human +DTXSID5045386 TK.Half.Life NA 7.665 hours 1compartment NA NA Rat Human +DTXSID5045386 Css NA 0.015 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045386 Css NA 0.1675 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045386 Css NA 0.01571 mg/L PBTK NA 50% Rat Human +DTXSID5045386 Css NA 0.117 mg/L PBTK NA 95% Rat Human +DTXSID5045388 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045388 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045388 Vd NA 0.327 L/kg 1compartment NA NA Human Human DTXSID5045388 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045388 TK.Half.Life NA 3.952 hours 1compartment NA NA Human Human -DTXSID5045388 Css NA 0.8898 mg/L 3compartmentss NA 50% Human Human -DTXSID5045388 Css NA 5.653 mg/L 3compartmentss NA 95% Human Human -DTXSID5045388 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID5045388 Css NA 3.572 mg/L PBTK NA 95% Human Human -DTXSID5045388 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045388 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045388 Vd NA 0.6351 L/kg 1compartment NA NA Rat Human +DTXSID5045388 TK.Half.Life NA 7.4 hours 1compartment NA NA Human Human +DTXSID5045388 Css NA 1.49 mg/L 3compartmentss NA 50% Human Human +DTXSID5045388 Css NA 6.142 mg/L 3compartmentss NA 95% Human Human +DTXSID5045388 Css NA 0.982 mg/L PBTK NA 50% Human Human +DTXSID5045388 Css NA 3.719 mg/L PBTK NA 95% Human Human +DTXSID5045388 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045388 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045388 Vd NA 0.3355 L/kg 1compartment NA NA Rat Human DTXSID5045388 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045388 TK.Half.Life NA 1.401 hours 1compartment NA NA Rat Human -DTXSID5045388 Css NA 0.2257 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045388 Css NA 1.361 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045388 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID5045388 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5045413 Clint NA 32.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045413 Fup NA 0.0569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045413 Vd NA 2.731 L/kg 1compartment NA NA Human Human +DTXSID5045388 TK.Half.Life NA 2.586 hours 1compartment NA NA Rat Human +DTXSID5045388 Css NA 0.008192 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045388 Css NA 0.03411 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045388 Css NA 0.005119 mg/L PBTK NA 50% Rat Human +DTXSID5045388 Css NA 0.01963 mg/L PBTK NA 95% Rat Human +DTXSID5045413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045413 Fup 0.0491 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045413 Vd NA 2.897 L/kg 1compartment NA NA Human Human DTXSID5045413 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045413 TK.Half.Life NA 5.514 hours 1compartment NA NA Human Human -DTXSID5045413 Css NA 0.1798 mg/L 3compartmentss NA 50% Human Human -DTXSID5045413 Css NA 1.428 mg/L 3compartmentss NA 95% Human Human -DTXSID5045413 Css NA 0.139 mg/L PBTK NA 50% Human Human -DTXSID5045413 Css NA 0.9997 mg/L PBTK NA 95% Human Human -DTXSID5045413 Clint NA 32.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045413 Fup NA 0.0569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045413 Vd NA 2.376 L/kg 1compartment NA NA Rat Human +DTXSID5045413 TK.Half.Life NA 8.146 hours 1compartment NA NA Human Human +DTXSID5045413 Css NA 0.2738 mg/L 3compartmentss NA 50% Human Human +DTXSID5045413 Css NA 2.207 mg/L 3compartmentss NA 95% Human Human +DTXSID5045413 Css NA 0.208 mg/L PBTK NA 50% Human Human +DTXSID5045413 Css NA 1.558 mg/L PBTK NA 95% Human Human +DTXSID5045413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045413 Fup 0.0491 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045413 Vd NA 2.436 L/kg 1compartment NA NA Rat Human DTXSID5045413 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045413 TK.Half.Life NA 2.25 hours 1compartment NA NA Rat Human -DTXSID5045413 Css NA 0.1008 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045413 Css NA 0.6628 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045413 Css NA 0.07456 mg/L PBTK NA 50% Rat Human -DTXSID5045413 Css NA 0.4485 mg/L PBTK NA 95% Rat Human -DTXSID5045417 Clint NA 15.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045417 Fup NA 0.1734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045417 Vd NA 0.9005 L/kg 1compartment NA NA Human Human -DTXSID5045417 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045417 TK.Half.Life NA 2.016 hours 1compartment NA NA Human Human -DTXSID5045417 Css NA 0.195 mg/L 3compartmentss NA 50% Human Human -DTXSID5045417 Css NA 1.321 mg/L 3compartmentss NA 95% Human Human -DTXSID5045417 Css NA 0.1336 mg/L PBTK NA 50% Human Human -DTXSID5045417 Css NA 0.8547 mg/L PBTK NA 95% Human Human -DTXSID5045417 Clint NA 15.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045417 Fup NA 0.1734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045417 Vd NA 0.7465 L/kg 1compartment NA NA Rat Human -DTXSID5045417 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045417 TK.Half.Life NA 0.9292 hours 1compartment NA NA Rat Human -DTXSID5045417 Css NA 0.1048 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045417 Css NA 0.5373 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045417 Css NA 0.06837 mg/L PBTK NA 50% Rat Human -DTXSID5045417 Css NA 0.3257 mg/L PBTK NA 95% Rat Human -DTXSID5045419 Clint NA 2.631 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045419 Fup NA 0.4661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045419 Vd NA 3.605 L/kg 1compartment NA NA Human Human +DTXSID5045413 TK.Half.Life NA 2.864 hours 1compartment NA NA Rat Human +DTXSID5045413 Css NA 0.0356 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045413 Css NA 0.2252 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045413 Css NA 0.02681 mg/L PBTK NA 50% Rat Human +DTXSID5045413 Css NA 0.1595 mg/L PBTK NA 95% Rat Human +DTXSID5045417 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045417 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045417 Vd NA 1.746 L/kg 1compartment NA NA Human Human +DTXSID5045417 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5045417 TK.Half.Life NA 33.96 hours 1compartment NA NA Human Human +DTXSID5045417 Css NA 1.905 mg/L 3compartmentss NA 50% Human Human +DTXSID5045417 Css NA 8.218 mg/L 3compartmentss NA 95% Human Human +DTXSID5045417 Css NA 1.576 mg/L PBTK NA 50% Human Human +DTXSID5045417 Css NA 5.595 mg/L PBTK NA 95% Human Human +DTXSID5045417 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045417 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045417 Vd NA 1.43 L/kg 1compartment NA NA Rat Human +DTXSID5045417 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5045417 TK.Half.Life NA 7.515 hours 1compartment NA NA Rat Human +DTXSID5045417 Css NA 0.1215 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045417 Css NA 0.4398 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045417 Css NA 0.1001 mg/L PBTK NA 50% Rat Human +DTXSID5045417 Css NA 0.2867 mg/L PBTK NA 95% Rat Human +DTXSID5045419 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045419 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045419 Vd NA 1.673 L/kg 1compartment NA NA Human Human DTXSID5045419 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045419 TK.Half.Life NA 10.07 hours 1compartment NA NA Human Human -DTXSID5045419 Css NA 0.1829 mg/L 3compartmentss NA 50% Human Human -DTXSID5045419 Css NA 1.42 mg/L 3compartmentss NA 95% Human Human -DTXSID5045419 Css NA 0.226 mg/L PBTK NA 50% Human Human -DTXSID5045419 Css NA 1.189 mg/L PBTK NA 95% Human Human -DTXSID5045419 Clint NA 2.631 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045419 Fup NA 0.4661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045419 Vd NA 3.664 L/kg 1compartment NA NA Rat Human +DTXSID5045419 TK.Half.Life NA 3.056 hours 1compartment NA NA Human Human +DTXSID5045419 Css NA 0.1099 mg/L 3compartmentss NA 50% Human Human +DTXSID5045419 Css NA 0.819 mg/L 3compartmentss NA 95% Human Human +DTXSID5045419 Css NA 0.09907 mg/L PBTK NA 50% Human Human +DTXSID5045419 Css NA 0.6093 mg/L PBTK NA 95% Human Human +DTXSID5045419 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045419 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045419 Vd NA 1.687 L/kg 1compartment NA NA Rat Human DTXSID5045419 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045419 TK.Half.Life NA 5.64 hours 1compartment NA NA Rat Human -DTXSID5045419 Css NA 0.07987 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045419 Css NA 0.5119 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045419 Css NA 0.09938 mg/L PBTK NA 50% Rat Human -DTXSID5045419 Css NA 0.3959 mg/L PBTK NA 95% Rat Human -DTXSID5045461 Clint NA 0.543 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045461 Fup NA 0.5114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045461 Vd NA 1.481 L/kg 1compartment NA NA Human Human -DTXSID5045461 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5045461 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human -DTXSID5045461 Css NA 0.7758 mg/L 3compartmentss NA 50% Human Human -DTXSID5045461 Css NA 4.217 mg/L 3compartmentss NA 95% Human Human -DTXSID5045461 Css NA 0.6576 mg/L PBTK NA 50% Human Human -DTXSID5045461 Css NA 2.817 mg/L PBTK NA 95% Human Human -DTXSID5045461 Clint NA 0.543 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045461 Fup NA 0.5114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045461 Vd NA 1.272 L/kg 1compartment NA NA Rat Human +DTXSID5045419 TK.Half.Life NA 1.749 hours 1compartment NA NA Rat Human +DTXSID5045419 Css NA 0.004545 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045419 Css NA 0.04044 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045419 Css NA 0.004219 mg/L PBTK NA 50% Rat Human +DTXSID5045419 Css NA 0.02963 mg/L PBTK NA 95% Rat Human +DTXSID5045461 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045461 Fup 0.52 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045461 Vd NA 1.624 L/kg 1compartment NA NA Human Human +DTXSID5045461 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5045461 TK.Half.Life NA 2.974 hours 1compartment NA NA Human Human +DTXSID5045461 Css NA 0.1156 mg/L 3compartmentss NA 50% Human Human +DTXSID5045461 Css NA 0.9353 mg/L 3compartmentss NA 95% Human Human +DTXSID5045461 Css NA 0.098 mg/L PBTK NA 50% Human Human +DTXSID5045461 Css NA 0.6606 mg/L PBTK NA 95% Human Human +DTXSID5045461 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045461 Fup 0.52 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045461 Vd NA 1.375 L/kg 1compartment NA NA Rat Human DTXSID5045461 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045461 TK.Half.Life NA 3.965 hours 1compartment NA NA Rat Human -DTXSID5045461 Css NA 0.2794 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045461 Css NA 1.329 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045461 Css NA 0.229 mg/L PBTK NA 50% Rat Human -DTXSID5045461 Css NA 0.8279 mg/L PBTK NA 95% Rat Human -DTXSID5045463 Clint NA 1057 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045463 Fup NA 0.2055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045463 Vd NA 2.208 L/kg 1compartment NA NA Human Human +DTXSID5045461 TK.Half.Life NA 1.243 hours 1compartment NA NA Rat Human +DTXSID5045461 Css NA 0.005114 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045461 Css NA 0.04301 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045461 Css NA 0.004338 mg/L PBTK NA 50% Rat Human +DTXSID5045461 Css NA 0.03079 mg/L PBTK NA 95% Rat Human +DTXSID5045463 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045463 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045463 Vd NA 2.529 L/kg 1compartment NA NA Human Human DTXSID5045463 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045463 TK.Half.Life NA 1.748 hours 1compartment NA NA Human Human -DTXSID5045463 Css NA 0.003629 mg/L 3compartmentss NA 50% Human Human -DTXSID5045463 Css NA 0.02462 mg/L 3compartmentss NA 95% Human Human -DTXSID5045463 Css NA 0.002655 mg/L PBTK NA 50% Human Human -DTXSID5045463 Css NA 0.01684 mg/L PBTK NA 95% Human Human -DTXSID5045463 Clint NA 1057 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045463 Fup NA 0.2055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045463 Vd NA 1.705 L/kg 1compartment NA NA Rat Human +DTXSID5045463 TK.Half.Life NA 4.81 hours 1compartment NA NA Human Human +DTXSID5045463 Css NA 0.1153 mg/L 3compartmentss NA 50% Human Human +DTXSID5045463 Css NA 0.8004 mg/L 3compartmentss NA 95% Human Human +DTXSID5045463 Css NA 0.0871 mg/L PBTK NA 50% Human Human +DTXSID5045463 Css NA 0.5742 mg/L PBTK NA 95% Human Human +DTXSID5045463 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045463 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045463 Vd NA 1.959 L/kg 1compartment NA NA Rat Human DTXSID5045463 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045463 TK.Half.Life NA 0.5835 hours 1compartment NA NA Rat Human -DTXSID5045463 Css NA 0.002027 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045463 Css NA 0.01146 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045463 Css NA 0.001424 mg/L PBTK NA 50% Rat Human -DTXSID5045463 Css NA 0.007719 mg/L PBTK NA 95% Rat Human +DTXSID5045463 TK.Half.Life NA 1.405 hours 1compartment NA NA Rat Human +DTXSID5045463 Css NA 0.005623 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045463 Css NA 0.03939 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045463 Css NA 0.004225 mg/L PBTK NA 50% Rat Human +DTXSID5045463 Css NA 0.02741 mg/L PBTK NA 95% Rat Human DTXSID5045465 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5045465 Fup NA 0.9939 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045465 Vd NA 0.7405 L/kg 1compartment NA NA Human Human +DTXSID5045465 Vd NA 0.6659 L/kg 1compartment NA NA Human Human DTXSID5045465 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045465 TK.Half.Life NA 4.82 hours 1compartment NA NA Human Human -DTXSID5045465 Css NA 0.8758 mg/L 3compartmentss NA 50% Human Human -DTXSID5045465 Css NA 5.403 mg/L 3compartmentss NA 95% Human Human -DTXSID5045465 Css NA 0.7236 mg/L PBTK NA 50% Human Human -DTXSID5045465 Css NA 3.507 mg/L PBTK NA 95% Human Human +DTXSID5045465 TK.Half.Life NA 4.335 hours 1compartment NA NA Human Human +DTXSID5045465 Css NA 0.7583 mg/L 3compartmentss NA 50% Human Human +DTXSID5045465 Css NA 4.476 mg/L 3compartmentss NA 95% Human Human +DTXSID5045465 Css NA 0.6156 mg/L PBTK NA 50% Human Human +DTXSID5045465 Css NA 2.868 mg/L PBTK NA 95% Human Human DTXSID5045465 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5045465 Fup NA 0.9939 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045465 Vd NA 0.7855 L/kg 1compartment NA NA Rat Human +DTXSID5045465 Vd NA 0.7248 L/kg 1compartment NA NA Rat Human DTXSID5045465 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045465 TK.Half.Life NA 1.742 hours 1compartment NA NA Rat Human -DTXSID5045465 Css NA 0.2218 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045465 Css NA 1.245 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045465 Css NA 0.1788 mg/L PBTK NA 50% Rat Human -DTXSID5045465 Css NA 0.7513 mg/L PBTK NA 95% Rat Human -DTXSID5045467 Clint NA 215.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045467 Fup NA 0.1667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045467 Vd NA 3.701 L/kg 1compartment NA NA Human Human +DTXSID5045465 TK.Half.Life NA 1.607 hours 1compartment NA NA Rat Human +DTXSID5045465 Css NA 0.01396 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045465 Css NA 0.101 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045465 Css NA 0.01097 mg/L PBTK NA 50% Rat Human +DTXSID5045465 Css NA 0.06561 mg/L PBTK NA 95% Rat Human +DTXSID5045467 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045467 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045467 Vd NA 1.009 L/kg 1compartment NA NA Human Human DTXSID5045467 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045467 TK.Half.Life NA 2.823 hours 1compartment NA NA Human Human -DTXSID5045467 Css NA 0.0146 mg/L 3compartmentss NA 50% Human Human -DTXSID5045467 Css NA 0.09964 mg/L 3compartmentss NA 95% Human Human -DTXSID5045467 Css NA 0.01308 mg/L PBTK NA 50% Human Human -DTXSID5045467 Css NA 0.08151 mg/L PBTK NA 95% Human Human -DTXSID5045467 Clint NA 215.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045467 Fup NA 0.1667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045467 Vd NA 3.194 L/kg 1compartment NA NA Rat Human +DTXSID5045467 TK.Half.Life NA 1.146 hours 1compartment NA NA Human Human +DTXSID5045467 Css NA 0.05135 mg/L 3compartmentss NA 50% Human Human +DTXSID5045467 Css NA 0.4077 mg/L 3compartmentss NA 95% Human Human +DTXSID5045467 Css NA 0.04018 mg/L PBTK NA 50% Human Human +DTXSID5045467 Css NA 0.2856 mg/L PBTK NA 95% Human Human +DTXSID5045467 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045467 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045467 Vd NA 1.022 L/kg 1compartment NA NA Rat Human DTXSID5045467 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045467 TK.Half.Life NA 1.009 hours 1compartment NA NA Rat Human -DTXSID5045467 Css NA 0.007916 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045467 Css NA 0.04546 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045467 Css NA 0.006937 mg/L PBTK NA 50% Rat Human -DTXSID5045467 Css NA 0.03618 mg/L PBTK NA 95% Rat Human +DTXSID5045467 TK.Half.Life NA 0.6107 hours 1compartment NA NA Rat Human +DTXSID5045467 Css NA 0.006413 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045467 Css NA 0.03704 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045467 Css NA 0.00504 mg/L PBTK NA 50% Rat Human +DTXSID5045467 Css NA 0.02576 mg/L PBTK NA 95% Rat Human DTXSID5045469 Clint 9.77 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5045469 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5045469 Vd NA 0.185 L/kg 1compartment NA NA Human Human +DTXSID5045469 Vd NA 0.1701 L/kg 1compartment NA NA Human Human DTXSID5045469 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5045469 TK.Half.Life NA 11.63 hours 1compartment NA NA Human Human -DTXSID5045469 Css NA 12.09 mg/L 3compartmentss NA 50% Human Human -DTXSID5045469 Css NA 104.3 mg/L 3compartmentss NA 95% Human Human -DTXSID5045469 Css NA 7.09 mg/L PBTK NA 50% Human Human -DTXSID5045469 Css NA 60.28 mg/L PBTK NA 95% Human Human +DTXSID5045469 TK.Half.Life NA 10.84 hours 1compartment NA NA Human Human +DTXSID5045469 Css NA 11.84 mg/L 3compartmentss NA 50% Human Human +DTXSID5045469 Css NA 106.6 mg/L 3compartmentss NA 95% Human Human +DTXSID5045469 Css NA 6.853 mg/L PBTK NA 50% Human Human +DTXSID5045469 Css NA 61.98 mg/L PBTK NA 95% Human Human DTXSID5045469 Clint 9.77 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5045469 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5045469 Vd NA 0.179 L/kg 1compartment NA NA Rat Human +DTXSID5045469 Vd NA 0.1676 L/kg 1compartment NA NA Rat Human DTXSID5045469 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045469 TK.Half.Life NA 7.403 hours 1compartment NA NA Rat Human -DTXSID5045469 Css NA 6.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045469 Css NA 48.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045469 Css NA 3.572 mg/L PBTK NA 50% Rat Human -DTXSID5045469 Css NA 26.21 mg/L PBTK NA 95% Rat Human -DTXSID5045540 Clint NA 1.613 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045540 Fup NA 0.7466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045540 Vd NA 1.027 L/kg 1compartment NA NA Human Human +DTXSID5045469 TK.Half.Life NA 7.019 hours 1compartment NA NA Rat Human +DTXSID5045469 Css NA 1.51 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045469 Css NA 10.57 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045469 Css NA 0.8479 mg/L PBTK NA 50% Rat Human +DTXSID5045469 Css NA 5.919 mg/L PBTK NA 95% Rat Human +DTXSID5045540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045540 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045540 Vd NA 0.7957 L/kg 1compartment NA NA Human Human DTXSID5045540 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045540 TK.Half.Life NA 2.802 hours 1compartment NA NA Human Human -DTXSID5045540 Css NA 0.2826 mg/L 3compartmentss NA 50% Human Human -DTXSID5045540 Css NA 1.956 mg/L 3compartmentss NA 95% Human Human -DTXSID5045540 Css NA 0.2426 mg/L PBTK NA 50% Human Human -DTXSID5045540 Css NA 1.306 mg/L PBTK NA 95% Human Human -DTXSID5045540 Clint NA 1.613 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045540 Fup NA 0.7466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045540 Vd NA 0.9844 L/kg 1compartment NA NA Rat Human +DTXSID5045540 TK.Half.Life NA 0.6802 hours 1compartment NA NA Human Human +DTXSID5045540 Css NA 0.03012 mg/L 3compartmentss NA 50% Human Human +DTXSID5045540 Css NA 0.3463 mg/L 3compartmentss NA 95% Human Human +DTXSID5045540 Css NA 0.02423 mg/L PBTK NA 50% Human Human +DTXSID5045540 Css NA 0.237 mg/L PBTK NA 95% Human Human +DTXSID5045540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045540 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045540 Vd NA 0.7926 L/kg 1compartment NA NA Rat Human DTXSID5045540 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045540 TK.Half.Life NA 1.349 hours 1compartment NA NA Rat Human -DTXSID5045540 Css NA 0.1138 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045540 Css NA 0.7857 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045540 Css NA 0.09601 mg/L PBTK NA 50% Rat Human -DTXSID5045540 Css NA 0.4848 mg/L PBTK NA 95% Rat Human -DTXSID5045544 Clint NA 92.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045544 Fup NA 0.028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045544 Vd NA 2.81 L/kg 1compartment NA NA Human Human +DTXSID5045540 TK.Half.Life NA 0.3334 hours 1compartment NA NA Rat Human +DTXSID5045540 Css NA 0.00358 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045540 Css NA 0.03458 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045540 Css NA 0.002974 mg/L PBTK NA 50% Rat Human +DTXSID5045540 Css NA 0.02311 mg/L PBTK NA 95% Rat Human +DTXSID5045544 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045544 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045544 Vd NA 0.4174 L/kg 1compartment NA NA Human Human DTXSID5045544 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045544 TK.Half.Life NA 1.909 hours 1compartment NA NA Human Human -DTXSID5045544 Css NA 0.006625 mg/L 3compartmentss NA 50% Human Human -DTXSID5045544 Css NA 0.06913 mg/L 3compartmentss NA 95% Human Human -DTXSID5045544 Css NA 0.005554 mg/L PBTK NA 50% Human Human -DTXSID5045544 Css NA 0.05035 mg/L PBTK NA 95% Human Human -DTXSID5045544 Clint NA 92.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045544 Fup NA 0.028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045544 Vd NA 2.489 L/kg 1compartment NA NA Rat Human +DTXSID5045544 TK.Half.Life NA 2.358 hours 1compartment NA NA Human Human +DTXSID5045544 Css NA 0.7772 mg/L 3compartmentss NA 50% Human Human +DTXSID5045544 Css NA 5.487 mg/L 3compartmentss NA 95% Human Human +DTXSID5045544 Css NA 0.49 mg/L PBTK NA 50% Human Human +DTXSID5045544 Css NA 3.309 mg/L PBTK NA 95% Human Human +DTXSID5045544 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045544 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045544 Vd NA 0.4139 L/kg 1compartment NA NA Rat Human DTXSID5045544 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045544 TK.Half.Life NA 0.7511 hours 1compartment NA NA Rat Human -DTXSID5045544 Css NA 0.003698 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045544 Css NA 0.03137 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045544 Css NA 0.002986 mg/L PBTK NA 50% Rat Human -DTXSID5045544 Css NA 0.02174 mg/L PBTK NA 95% Rat Human -DTXSID5045546 Clint NA 1.247 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045546 Fup NA 0.121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045546 Vd NA 0.3601 L/kg 1compartment NA NA Human Human +DTXSID5045544 TK.Half.Life NA 1.417 hours 1compartment NA NA Rat Human +DTXSID5045544 Css NA 0.09468 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045544 Css NA 0.4985 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045544 Css NA 0.05834 mg/L PBTK NA 50% Rat Human +DTXSID5045544 Css NA 0.2867 mg/L PBTK NA 95% Rat Human +DTXSID5045546 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045546 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045546 Vd NA 0.4427 L/kg 1compartment NA NA Human Human DTXSID5045546 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045546 TK.Half.Life NA 6.412 hours 1compartment NA NA Human Human -DTXSID5045546 Css NA 2.696 mg/L 3compartmentss NA 50% Human Human -DTXSID5045546 Css NA 14.36 mg/L 3compartmentss NA 95% Human Human -DTXSID5045546 Css NA 1.688 mg/L PBTK NA 50% Human Human -DTXSID5045546 Css NA 8.577 mg/L PBTK NA 95% Human Human -DTXSID5045546 Clint NA 1.247 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045546 Fup NA 0.121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045546 Vd NA 0.3341 L/kg 1compartment NA NA Rat Human +DTXSID5045546 TK.Half.Life NA 1.958 hours 1compartment NA NA Human Human +DTXSID5045546 Css NA 0.4744 mg/L 3compartmentss NA 50% Human Human +DTXSID5045546 Css NA 3.343 mg/L 3compartmentss NA 95% Human Human +DTXSID5045546 Css NA 0.3082 mg/L PBTK NA 50% Human Human +DTXSID5045546 Css NA 2.02 mg/L PBTK NA 95% Human Human +DTXSID5045546 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045546 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045546 Vd NA 0.4024 L/kg 1compartment NA NA Rat Human DTXSID5045546 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045546 TK.Half.Life NA 3.058 hours 1compartment NA NA Rat Human -DTXSID5045546 Css NA 1.167 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045546 Css NA 4.991 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045546 Css NA 0.6879 mg/L PBTK NA 50% Rat Human -DTXSID5045546 Css NA 2.764 mg/L PBTK NA 95% Rat Human -DTXSID5045590 Clint NA 32.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045590 Fup NA 0.3253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045590 Vd NA 0.3029 L/kg 1compartment NA NA Human Human +DTXSID5045546 TK.Half.Life NA 1.056 hours 1compartment NA NA Rat Human +DTXSID5045546 Css NA 0.02132 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045546 Css NA 0.1692 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045546 Css NA 0.01339 mg/L PBTK NA 50% Rat Human +DTXSID5045546 Css NA 0.1001 mg/L PBTK NA 95% Rat Human +DTXSID5045590 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045590 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045590 Vd NA 0.2955 L/kg 1compartment NA NA Human Human DTXSID5045590 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045590 TK.Half.Life NA 0.3471 hours 1compartment NA NA Human Human -DTXSID5045590 Css NA 0.04548 mg/L 3compartmentss NA 50% Human Human -DTXSID5045590 Css NA 0.3338 mg/L 3compartmentss NA 95% Human Human -DTXSID5045590 Css NA 0.02985 mg/L PBTK NA 50% Human Human -DTXSID5045590 Css NA 0.212 mg/L PBTK NA 95% Human Human -DTXSID5045590 Clint NA 32.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045590 Fup NA 0.3253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045590 Vd NA 0.3127 L/kg 1compartment NA NA Rat Human +DTXSID5045590 TK.Half.Life NA 7.187 hours 1compartment NA NA Human Human +DTXSID5045590 Css NA 1.629 mg/L 3compartmentss NA 50% Human Human +DTXSID5045590 Css NA 6.526 mg/L 3compartmentss NA 95% Human Human +DTXSID5045590 Css NA 1.059 mg/L PBTK NA 50% Human Human +DTXSID5045590 Css NA 3.967 mg/L PBTK NA 95% Human Human +DTXSID5045590 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045590 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045590 Vd NA 0.3017 L/kg 1compartment NA NA Rat Human DTXSID5045590 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045590 TK.Half.Life NA 0.1788 hours 1compartment NA NA Rat Human -DTXSID5045590 Css NA 0.02512 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045590 Css NA 0.1461 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045590 Css NA 0.01555 mg/L PBTK NA 50% Rat Human -DTXSID5045590 Css NA 0.08709 mg/L PBTK NA 95% Rat Human -DTXSID5045594 Clint NA 0.2799 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045594 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045594 Vd NA 0.252 L/kg 1compartment NA NA Human Human -DTXSID5045594 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID5045594 TK.Half.Life NA 43.16 hours 1compartment NA NA Human Human -DTXSID5045594 Css NA 28.82 mg/L 3compartmentss NA 50% Human Human -DTXSID5045594 Css NA 179.3 mg/L 3compartmentss NA 95% Human Human -DTXSID5045594 Css NA 17.05 mg/L PBTK NA 50% Human Human -DTXSID5045594 Css NA 104.6 mg/L PBTK NA 95% Human Human -DTXSID5045594 Clint NA 0.2799 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045594 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045594 Vd NA 0.2292 L/kg 1compartment NA NA Rat Human -DTXSID5045594 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5045594 TK.Half.Life NA 15.99 hours 1compartment NA NA Rat Human -DTXSID5045594 Css NA 10.02 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045594 Css NA 54.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045594 Css NA 5.538 mg/L PBTK NA 50% Rat Human -DTXSID5045594 Css NA 29.66 mg/L PBTK NA 95% Rat Human -DTXSID5045596 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045596 Fup NA 0.2779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045596 Vd NA 0.3927 L/kg 1compartment NA NA Human Human -DTXSID5045596 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045596 TK.Half.Life NA 9.143 hours 1compartment NA NA Human Human -DTXSID5045596 Css NA 2.81 mg/L 3compartmentss NA 50% Human Human -DTXSID5045596 Css NA 10.69 mg/L 3compartmentss NA 95% Human Human -DTXSID5045596 Css NA 1.92 mg/L PBTK NA 50% Human Human -DTXSID5045596 Css NA 6.552 mg/L PBTK NA 95% Human Human -DTXSID5045596 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045596 Fup NA 0.2779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045596 Vd NA 0.4042 L/kg 1compartment NA NA Rat Human -DTXSID5045596 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045596 TK.Half.Life NA 3.206 hours 1compartment NA NA Rat Human -DTXSID5045596 Css NA 0.7724 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045596 Css NA 2.508 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045596 Css NA 0.4988 mg/L PBTK NA 50% Rat Human -DTXSID5045596 Css NA 1.446 mg/L PBTK NA 95% Rat Human -DTXSID5045598 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045598 Fup NA 0.1548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045598 Vd NA 2.575 L/kg 1compartment NA NA Human Human +DTXSID5045590 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human +DTXSID5045590 Css NA 0.008866 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045590 Css NA 0.0373 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045590 Css NA 0.005448 mg/L PBTK NA 50% Rat Human +DTXSID5045590 Css NA 0.0216 mg/L PBTK NA 95% Rat Human +DTXSID5045594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045594 Fup 0.0462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045594 Vd NA 0.3049 L/kg 1compartment NA NA Human Human +DTXSID5045594 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5045594 TK.Half.Life NA 1.406 hours 1compartment NA NA Human Human +DTXSID5045594 Css NA 0.6688 mg/L 3compartmentss NA 50% Human Human +DTXSID5045594 Css NA 5.18 mg/L 3compartmentss NA 95% Human Human +DTXSID5045594 Css NA 0.4014 mg/L PBTK NA 50% Human Human +DTXSID5045594 Css NA 3.018 mg/L PBTK NA 95% Human Human +DTXSID5045594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045594 Fup 0.0462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045594 Vd NA 0.274 L/kg 1compartment NA NA Rat Human +DTXSID5045594 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5045594 TK.Half.Life NA 0.794 hours 1compartment NA NA Rat Human +DTXSID5045594 Css NA 0.0876 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045594 Css NA 0.5369 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045594 Css NA 0.05104 mg/L PBTK NA 50% Rat Human +DTXSID5045594 Css NA 0.3073 mg/L PBTK NA 95% Rat Human +DTXSID5045598 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045598 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045598 Vd NA 0.4088 L/kg 1compartment NA NA Human Human DTXSID5045598 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045598 TK.Half.Life NA 11.7 hours 1compartment NA NA Human Human -DTXSID5045598 Css NA 0.4965 mg/L 3compartmentss NA 50% Human Human -DTXSID5045598 Css NA 3.096 mg/L 3compartmentss NA 95% Human Human -DTXSID5045598 Css NA 0.3508 mg/L PBTK NA 50% Human Human -DTXSID5045598 Css NA 2.143 mg/L PBTK NA 95% Human Human -DTXSID5045598 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045598 Fup NA 0.1548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045598 Vd NA 1.965 L/kg 1compartment NA NA Rat Human +DTXSID5045598 TK.Half.Life NA 1.42 hours 1compartment NA NA Human Human +DTXSID5045598 Css NA 0.3042 mg/L 3compartmentss NA 50% Human Human +DTXSID5045598 Css NA 1.785 mg/L 3compartmentss NA 95% Human Human +DTXSID5045598 Css NA 0.2006 mg/L PBTK NA 50% Human Human +DTXSID5045598 Css NA 1.116 mg/L PBTK NA 95% Human Human +DTXSID5045598 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045598 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045598 Vd NA 0.4122 L/kg 1compartment NA NA Rat Human DTXSID5045598 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045598 TK.Half.Life NA 3.047 hours 1compartment NA NA Rat Human -DTXSID5045598 Css NA 0.273 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045598 Css NA 1.269 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045598 Css NA 0.1854 mg/L PBTK NA 50% Rat Human -DTXSID5045598 Css NA 0.8375 mg/L PBTK NA 95% Rat Human -DTXSID5045623 Clint NA 1.089 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045623 Fup NA 0.0572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045623 Vd NA 0.2718 L/kg 1compartment NA NA Human Human -DTXSID5045623 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5045623 TK.Half.Life NA 11.02 hours 1compartment NA NA Human Human -DTXSID5045623 Css NA 6.803 mg/L 3compartmentss NA 50% Human Human -DTXSID5045623 Css NA 35.25 mg/L 3compartmentss NA 95% Human Human -DTXSID5045623 Css NA 4.146 mg/L PBTK NA 50% Human Human -DTXSID5045623 Css NA 20.53 mg/L PBTK NA 95% Human Human -DTXSID5045623 Clint NA 1.089 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045623 Fup NA 0.0572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045623 Vd NA 0.2694 L/kg 1compartment NA NA Rat Human +DTXSID5045598 TK.Half.Life NA 0.8383 hours 1compartment NA NA Rat Human +DTXSID5045598 Css NA 0.01368 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045598 Css NA 0.09368 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045598 Css NA 0.008806 mg/L PBTK NA 50% Rat Human +DTXSID5045598 Css NA 0.05693 mg/L PBTK NA 95% Rat Human +DTXSID5045623 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045623 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045623 Vd NA 0.5005 L/kg 1compartment NA NA Human Human +DTXSID5045623 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5045623 TK.Half.Life NA 1.613 hours 1compartment NA NA Human Human +DTXSID5045623 Css NA 0.3075 mg/L 3compartmentss NA 50% Human Human +DTXSID5045623 Css NA 1.84 mg/L 3compartmentss NA 95% Human Human +DTXSID5045623 Css NA 0.215 mg/L PBTK NA 50% Human Human +DTXSID5045623 Css NA 1.198 mg/L PBTK NA 95% Human Human +DTXSID5045623 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045623 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045623 Vd NA 0.5012 L/kg 1compartment NA NA Rat Human DTXSID5045623 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045623 TK.Half.Life NA 5.545 hours 1compartment NA NA Rat Human -DTXSID5045623 Css NA 2.87 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045623 Css NA 12.51 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045623 Css NA 1.625 mg/L PBTK NA 50% Rat Human -DTXSID5045623 Css NA 6.847 mg/L PBTK NA 95% Rat Human -DTXSID5045625 Clint NA 20.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045625 Fup NA 0.1049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045625 Vd NA 0.7778 L/kg 1compartment NA NA Human Human +DTXSID5045623 TK.Half.Life NA 0.9467 hours 1compartment NA NA Rat Human +DTXSID5045623 Css NA 0.03678 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045623 Css NA 0.1655 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045623 Css NA 0.02545 mg/L PBTK NA 50% Rat Human +DTXSID5045623 Css NA 0.1041 mg/L PBTK NA 95% Rat Human +DTXSID5045625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045625 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045625 Vd NA 1.483 L/kg 1compartment NA NA Human Human DTXSID5045625 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045625 TK.Half.Life NA 2.017 hours 1compartment NA NA Human Human -DTXSID5045625 Css NA 0.2864 mg/L 3compartmentss NA 50% Human Human -DTXSID5045625 Css NA 2.211 mg/L 3compartmentss NA 95% Human Human -DTXSID5045625 Css NA 0.1845 mg/L PBTK NA 50% Human Human -DTXSID5045625 Css NA 1.371 mg/L PBTK NA 95% Human Human -DTXSID5045625 Clint NA 20.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045625 Fup NA 0.1049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045625 Vd NA 0.6357 L/kg 1compartment NA NA Rat Human +DTXSID5045625 TK.Half.Life NA 1.846 hours 1compartment NA NA Human Human +DTXSID5045625 Css NA 0.0622 mg/L 3compartmentss NA 50% Human Human +DTXSID5045625 Css NA 0.4481 mg/L 3compartmentss NA 95% Human Human +DTXSID5045625 Css NA 0.04866 mg/L PBTK NA 50% Human Human +DTXSID5045625 Css NA 0.3165 mg/L PBTK NA 95% Human Human +DTXSID5045625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045625 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045625 Vd NA 1.224 L/kg 1compartment NA NA Rat Human DTXSID5045625 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045625 TK.Half.Life NA 0.9455 hours 1compartment NA NA Rat Human -DTXSID5045625 Css NA 0.1615 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045625 Css NA 0.9654 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045625 Css NA 0.0977 mg/L PBTK NA 50% Rat Human -DTXSID5045625 Css NA 0.5549 mg/L PBTK NA 95% Rat Human -DTXSID5045671 Clint NA 47.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045671 Fup NA 0.3264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045671 Vd NA 2.658 L/kg 1compartment NA NA Human Human +DTXSID5045625 TK.Half.Life NA 0.7468 hours 1compartment NA NA Rat Human +DTXSID5045625 Css NA 0.007836 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045625 Css NA 0.04418 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045625 Css NA 0.006097 mg/L PBTK NA 50% Rat Human +DTXSID5045625 Css NA 0.03183 mg/L PBTK NA 95% Rat Human +DTXSID5045671 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045671 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045671 Vd NA 2.442 L/kg 1compartment NA NA Human Human DTXSID5045671 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045671 TK.Half.Life NA 3.218 hours 1compartment NA NA Human Human -DTXSID5045671 Css NA 0.05952 mg/L 3compartmentss NA 50% Human Human -DTXSID5045671 Css NA 0.3942 mg/L 3compartmentss NA 95% Human Human -DTXSID5045671 Css NA 0.04701 mg/L PBTK NA 50% Human Human -DTXSID5045671 Css NA 0.2911 mg/L PBTK NA 95% Human Human -DTXSID5045671 Clint NA 47.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045671 Fup NA 0.3264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045671 Vd NA 2.114 L/kg 1compartment NA NA Rat Human +DTXSID5045671 TK.Half.Life NA 8.975 hours 1compartment NA NA Human Human +DTXSID5045671 Css NA 0.3252 mg/L 3compartmentss NA 50% Human Human +DTXSID5045671 Css NA 1.902 mg/L 3compartmentss NA 95% Human Human +DTXSID5045671 Css NA 0.2596 mg/L PBTK NA 50% Human Human +DTXSID5045671 Css NA 1.395 mg/L PBTK NA 95% Human Human +DTXSID5045671 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045671 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045671 Vd NA 1.97 L/kg 1compartment NA NA Rat Human DTXSID5045671 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045671 TK.Half.Life NA 1.022 hours 1compartment NA NA Rat Human -DTXSID5045671 Css NA 0.0324 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045671 Css NA 0.1717 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045671 Css NA 0.02477 mg/L PBTK NA 50% Rat Human -DTXSID5045671 Css NA 0.1214 mg/L PBTK NA 95% Rat Human -DTXSID5045673 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045673 Fup NA 0.7448 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045673 Vd NA 2.633 L/kg 1compartment NA NA Human Human +DTXSID5045671 TK.Half.Life NA 2.877 hours 1compartment NA NA Rat Human +DTXSID5045671 Css NA 0.03888 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045671 Css NA 0.1606 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045671 Css NA 0.03115 mg/L PBTK NA 50% Rat Human +DTXSID5045671 Css NA 0.1147 mg/L PBTK NA 95% Rat Human +DTXSID5045673 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045673 Fup 0.646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045673 Vd NA 0.5852 L/kg 1compartment NA NA Human Human DTXSID5045673 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045673 TK.Half.Life NA 3.79 hours 1compartment NA NA Human Human -DTXSID5045673 Css NA 0.1054 mg/L 3compartmentss NA 50% Human Human -DTXSID5045673 Css NA 0.9541 mg/L 3compartmentss NA 95% Human Human -DTXSID5045673 Css NA 0.1146 mg/L PBTK NA 50% Human Human -DTXSID5045673 Css NA 0.7399 mg/L PBTK NA 95% Human Human -DTXSID5045673 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045673 Fup NA 0.7448 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045673 Vd NA 2.674 L/kg 1compartment NA NA Rat Human +DTXSID5045673 TK.Half.Life NA 5.859 hours 1compartment NA NA Human Human +DTXSID5045673 Css NA 1.028 mg/L 3compartmentss NA 50% Human Human +DTXSID5045673 Css NA 6.693 mg/L 3compartmentss NA 95% Human Human +DTXSID5045673 Css NA 0.8022 mg/L PBTK NA 50% Human Human +DTXSID5045673 Css NA 4.188 mg/L PBTK NA 95% Human Human +DTXSID5045673 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045673 Fup 0.646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045673 Vd NA 0.616 L/kg 1compartment NA NA Rat Human DTXSID5045673 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045673 TK.Half.Life NA 2.128 hours 1compartment NA NA Rat Human -DTXSID5045673 Css NA 0.04714 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045673 Css NA 0.4012 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045673 Css NA 0.05224 mg/L PBTK NA 50% Rat Human -DTXSID5045673 Css NA 0.2746 mg/L PBTK NA 95% Rat Human -DTXSID5045675 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045675 Fup NA 0.8359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045675 Vd NA 0.9195 L/kg 1compartment NA NA Human Human -DTXSID5045675 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045675 TK.Half.Life NA 7.202 hours 1compartment NA NA Human Human -DTXSID5045675 Css NA 0.9259 mg/L 3compartmentss NA 50% Human Human -DTXSID5045675 Css NA 5.788 mg/L 3compartmentss NA 95% Human Human -DTXSID5045675 Css NA 0.7979 mg/L PBTK NA 50% Human Human -DTXSID5045675 Css NA 3.778 mg/L PBTK NA 95% Human Human -DTXSID5045675 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045675 Fup NA 0.8359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045675 Vd NA 0.9159 L/kg 1compartment NA NA Rat Human +DTXSID5045673 TK.Half.Life NA 2.102 hours 1compartment NA NA Rat Human +DTXSID5045673 Css NA 0.02685 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045673 Css NA 0.1928 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045673 Css NA 0.02019 mg/L PBTK NA 50% Rat Human +DTXSID5045673 Css NA 0.1203 mg/L PBTK NA 95% Rat Human +DTXSID5045675 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045675 Fup 0.682 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045675 Vd NA 1.402 L/kg 1compartment NA NA Human Human +DTXSID5045675 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5045675 TK.Half.Life NA 15.08 hours 1compartment NA NA Human Human +DTXSID5045675 Css NA 0.5912 mg/L 3compartmentss NA 50% Human Human +DTXSID5045675 Css NA 4.313 mg/L 3compartmentss NA 95% Human Human +DTXSID5045675 Css NA 0.5308 mg/L PBTK NA 50% Human Human +DTXSID5045675 Css NA 2.817 mg/L PBTK NA 95% Human Human +DTXSID5045675 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045675 Fup 0.682 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045675 Vd NA 1.242 L/kg 1compartment NA NA Rat Human DTXSID5045675 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045675 TK.Half.Life NA 2.422 hours 1compartment NA NA Rat Human -DTXSID5045675 Css NA 0.2392 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045675 Css NA 1.471 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045675 Css NA 0.1999 mg/L PBTK NA 50% Rat Human -DTXSID5045675 Css NA 0.8919 mg/L PBTK NA 95% Rat Human -DTXSID5045677 Clint NA 10.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045677 Fup NA 0.3447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045677 Vd NA 2.199 L/kg 1compartment NA NA Human Human +DTXSID5045675 TK.Half.Life NA 4.143 hours 1compartment NA NA Rat Human +DTXSID5045675 Css NA 0.003067 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045675 Css NA 0.02247 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045675 Css NA 0.002686 mg/L PBTK NA 50% Rat Human +DTXSID5045675 Css NA 0.0147 mg/L PBTK NA 95% Rat Human +DTXSID5045677 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045677 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045677 Vd NA 1.98 L/kg 1compartment NA NA Human Human DTXSID5045677 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045677 TK.Half.Life NA 4.128 hours 1compartment NA NA Human Human -DTXSID5045677 Css NA 0.1357 mg/L 3compartmentss NA 50% Human Human -DTXSID5045677 Css NA 0.8949 mg/L 3compartmentss NA 95% Human Human -DTXSID5045677 Css NA 0.1146 mg/L PBTK NA 50% Human Human -DTXSID5045677 Css NA 0.6778 mg/L PBTK NA 95% Human Human -DTXSID5045677 Clint NA 10.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045677 Fup NA 0.3447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045677 Vd NA 1.906 L/kg 1compartment NA NA Rat Human +DTXSID5045677 TK.Half.Life NA 6.054 hours 1compartment NA NA Human Human +DTXSID5045677 Css NA 0.2584 mg/L 3compartmentss NA 50% Human Human +DTXSID5045677 Css NA 1.597 mg/L 3compartmentss NA 95% Human Human +DTXSID5045677 Css NA 0.2093 mg/L PBTK NA 50% Human Human +DTXSID5045677 Css NA 1.159 mg/L PBTK NA 95% Human Human +DTXSID5045677 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045677 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045677 Vd NA 1.71 L/kg 1compartment NA NA Rat Human DTXSID5045677 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045677 TK.Half.Life NA 1.728 hours 1compartment NA NA Rat Human -DTXSID5045677 Css NA 0.07143 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045677 Css NA 0.3507 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045677 Css NA 0.05868 mg/L PBTK NA 50% Rat Human -DTXSID5045677 Css NA 0.2518 mg/L PBTK NA 95% Rat Human -DTXSID5045679 Clint NA 1.636 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045679 Fup NA 0.2752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045679 Vd NA 1.246 L/kg 1compartment NA NA Human Human +DTXSID5045677 TK.Half.Life NA 2.604 hours 1compartment NA NA Rat Human +DTXSID5045677 Css NA 0.03041 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045677 Css NA 0.1348 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045677 Css NA 0.02468 mg/L PBTK NA 50% Rat Human +DTXSID5045677 Css NA 0.09609 mg/L PBTK NA 95% Rat Human +DTXSID5045679 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045679 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045679 Vd NA 1.377 L/kg 1compartment NA NA Human Human DTXSID5045679 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045679 TK.Half.Life NA 8.336 hours 1compartment NA NA Human Human -DTXSID5045679 Css NA 0.6732 mg/L 3compartmentss NA 50% Human Human -DTXSID5045679 Css NA 3.343 mg/L 3compartmentss NA 95% Human Human -DTXSID5045679 Css NA 0.5314 mg/L PBTK NA 50% Human Human -DTXSID5045679 Css NA 2.274 mg/L PBTK NA 95% Human Human -DTXSID5045679 Clint NA 1.636 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045679 Fup NA 0.2752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045679 Vd NA 1.249 L/kg 1compartment NA NA Rat Human +DTXSID5045679 TK.Half.Life NA 2.997 hours 1compartment NA NA Human Human +DTXSID5045679 Css NA 0.1422 mg/L 3compartmentss NA 50% Human Human +DTXSID5045679 Css NA 0.9797 mg/L 3compartmentss NA 95% Human Human +DTXSID5045679 Css NA 0.118 mg/L PBTK NA 50% Human Human +DTXSID5045679 Css NA 0.7103 mg/L PBTK NA 95% Human Human +DTXSID5045679 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045679 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045679 Vd NA 1.385 L/kg 1compartment NA NA Rat Human DTXSID5045679 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045679 TK.Half.Life NA 4.435 hours 1compartment NA NA Rat Human -DTXSID5045679 Css NA 0.2927 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045679 Css NA 1.174 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045679 Css NA 0.2242 mg/L PBTK NA 50% Rat Human -DTXSID5045679 Css NA 0.7332 mg/L PBTK NA 95% Rat Human -DTXSID5045700 Clint NA 2.711 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045700 Fup NA 0.0449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045700 Vd NA 1.577 L/kg 1compartment NA NA Human Human -DTXSID5045700 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID5045700 TK.Half.Life NA 48.78 hours 1compartment NA NA Human Human -DTXSID5045700 Css NA 4.931 mg/L 3compartmentss NA 50% Human Human -DTXSID5045700 Css NA 26.23 mg/L 3compartmentss NA 95% Human Human -DTXSID5045700 Css NA 3.164 mg/L PBTK NA 50% Human Human -DTXSID5045700 Css NA 16.16 mg/L PBTK NA 95% Human Human -DTXSID5045700 Clint NA 2.711 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045700 Fup NA 0.0449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045700 Vd NA 1.183 L/kg 1compartment NA NA Rat Human -DTXSID5045700 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5045700 TK.Half.Life NA 16.77 hours 1compartment NA NA Rat Human -DTXSID5045700 Css NA 2.449 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045700 Css NA 10.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045700 Css NA 1.472 mg/L PBTK NA 50% Rat Human -DTXSID5045700 Css NA 5.662 mg/L PBTK NA 95% Rat Human -DTXSID5045702 Clint NA 17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045702 Fup NA 0.2424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045702 Vd NA 1.876 L/kg 1compartment NA NA Human Human +DTXSID5045679 TK.Half.Life NA 1.727 hours 1compartment NA NA Rat Human +DTXSID5045679 Css NA 0.006084 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045679 Css NA 0.0479 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045679 Css NA 0.005145 mg/L PBTK NA 50% Rat Human +DTXSID5045679 Css NA 0.0339 mg/L PBTK NA 95% Rat Human +DTXSID5045700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045700 Fup 0.0492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045700 Vd NA 1.639 L/kg 1compartment NA NA Human Human +DTXSID5045700 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5045700 TK.Half.Life NA 8.04 hours 1compartment NA NA Human Human +DTXSID5045700 Css NA 0.6529 mg/L 3compartmentss NA 50% Human Human +DTXSID5045700 Css NA 5.129 mg/L 3compartmentss NA 95% Human Human +DTXSID5045700 Css NA 0.4158 mg/L PBTK NA 50% Human Human +DTXSID5045700 Css NA 3.106 mg/L PBTK NA 95% Human Human +DTXSID5045700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045700 Fup 0.0492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045700 Vd NA 1.23 L/kg 1compartment NA NA Rat Human +DTXSID5045700 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5045700 TK.Half.Life NA 2.977 hours 1compartment NA NA Rat Human +DTXSID5045700 Css NA 0.08424 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045700 Css NA 0.5151 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045700 Css NA 0.05295 mg/L PBTK NA 50% Rat Human +DTXSID5045700 Css NA 0.3076 mg/L PBTK NA 95% Rat Human +DTXSID5045702 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045702 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045702 Vd NA 1.948 L/kg 1compartment NA NA Human Human DTXSID5045702 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045702 TK.Half.Life NA 3.408 hours 1compartment NA NA Human Human -DTXSID5045702 Css NA 0.1319 mg/L 3compartmentss NA 50% Human Human -DTXSID5045702 Css NA 0.8787 mg/L 3compartmentss NA 95% Human Human -DTXSID5045702 Css NA 0.1015 mg/L PBTK NA 50% Human Human -DTXSID5045702 Css NA 0.6279 mg/L PBTK NA 95% Human Human -DTXSID5045702 Clint NA 17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045702 Fup NA 0.2424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045702 Vd NA 1.555 L/kg 1compartment NA NA Rat Human +DTXSID5045702 TK.Half.Life NA 4.649 hours 1compartment NA NA Human Human +DTXSID5045702 Css NA 0.1889 mg/L 3compartmentss NA 50% Human Human +DTXSID5045702 Css NA 1.232 mg/L 3compartmentss NA 95% Human Human +DTXSID5045702 Css NA 0.1582 mg/L PBTK NA 50% Human Human +DTXSID5045702 Css NA 0.8971 mg/L PBTK NA 95% Human Human +DTXSID5045702 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045702 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045702 Vd NA 1.676 L/kg 1compartment NA NA Rat Human DTXSID5045702 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045702 TK.Half.Life NA 1.377 hours 1compartment NA NA Rat Human -DTXSID5045702 Css NA 0.07076 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045702 Css NA 0.3661 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045702 Css NA 0.05256 mg/L PBTK NA 50% Rat Human -DTXSID5045702 Css NA 0.247 mg/L PBTK NA 95% Rat Human -DTXSID5045704 Clint NA 8.773 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5045702 TK.Half.Life NA 1.96 hours 1compartment NA NA Rat Human +DTXSID5045702 Css NA 0.02171 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045702 Css NA 0.1051 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045702 Css NA 0.01829 mg/L PBTK NA 50% Rat Human +DTXSID5045702 Css NA 0.07401 mg/L PBTK NA 95% Rat Human +DTXSID5045704 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5045704 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5045704 Vd NA 1.121 L/kg 1compartment NA NA Human Human +DTXSID5045704 Vd NA 2.765 L/kg 1compartment NA NA Human Human DTXSID5045704 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045704 TK.Half.Life NA 1.154 hours 1compartment NA NA Human Human -DTXSID5045704 Css NA 0.06446 mg/L 3compartmentss NA 50% Human Human -DTXSID5045704 Css NA 0.5618 mg/L 3compartmentss NA 95% Human Human -DTXSID5045704 Css NA 0.05614 mg/L PBTK NA 50% Human Human -DTXSID5045704 Css NA 0.403 mg/L PBTK NA 95% Human Human -DTXSID5045704 Clint NA 8.773 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5045704 TK.Half.Life NA 7.051 hours 1compartment NA NA Human Human +DTXSID5045704 Css NA 0.212 mg/L 3compartmentss NA 50% Human Human +DTXSID5045704 Css NA 1.385 mg/L 3compartmentss NA 95% Human Human +DTXSID5045704 Css NA 0.1778 mg/L PBTK NA 50% Human Human +DTXSID5045704 Css NA 1.045 mg/L PBTK NA 95% Human Human +DTXSID5045704 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5045704 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5045704 Vd NA 1.061 L/kg 1compartment NA NA Rat Human +DTXSID5045704 Vd NA 2.176 L/kg 1compartment NA NA Rat Human DTXSID5045704 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045704 TK.Half.Life NA 0.5608 hours 1compartment NA NA Rat Human -DTXSID5045704 Css NA 0.03135 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045704 Css NA 0.2459 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045704 Css NA 0.02703 mg/L PBTK NA 50% Rat Human -DTXSID5045704 Css NA 0.1585 mg/L PBTK NA 95% Rat Human -DTXSID5045706 Clint NA 94.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045706 Fup NA 0.2833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045706 Vd NA 3.933 L/kg 1compartment NA NA Human Human +DTXSID5045704 TK.Half.Life NA 1.775 hours 1compartment NA NA Rat Human +DTXSID5045704 Css NA 0.02436 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045704 Css NA 0.117 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045704 Css NA 0.02082 mg/L PBTK NA 50% Rat Human +DTXSID5045704 Css NA 0.08453 mg/L PBTK NA 95% Rat Human +DTXSID5045706 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045706 Fup 0.324 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045706 Vd NA 3.047 L/kg 1compartment NA NA Human Human DTXSID5045706 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045706 TK.Half.Life NA 2.002 hours 1compartment NA NA Human Human -DTXSID5045706 Css NA 0.007344 mg/L 3compartmentss NA 50% Human Human -DTXSID5045706 Css NA 0.0699 mg/L 3compartmentss NA 95% Human Human -DTXSID5045706 Css NA 0.00958 mg/L PBTK NA 50% Human Human -DTXSID5045706 Css NA 0.07332 mg/L PBTK NA 95% Human Human -DTXSID5045706 Clint NA 94.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045706 Fup NA 0.2833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045706 Vd NA 3.973 L/kg 1compartment NA NA Rat Human +DTXSID5045706 TK.Half.Life NA 5.986 hours 1compartment NA NA Human Human +DTXSID5045706 Css NA 0.1162 mg/L 3compartmentss NA 50% Human Human +DTXSID5045706 Css NA 0.9056 mg/L 3compartmentss NA 95% Human Human +DTXSID5045706 Css NA 0.134 mg/L PBTK NA 50% Human Human +DTXSID5045706 Css NA 0.8072 mg/L PBTK NA 95% Human Human +DTXSID5045706 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045706 Fup 0.324 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045706 Vd NA 3.068 L/kg 1compartment NA NA Rat Human DTXSID5045706 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045706 TK.Half.Life NA 0.9828 hours 1compartment NA NA Rat Human -DTXSID5045706 Css NA 0.003913 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045706 Css NA 0.02952 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045706 Css NA 0.005138 mg/L PBTK NA 50% Rat Human -DTXSID5045706 Css NA 0.03007 mg/L PBTK NA 95% Rat Human -DTXSID5045708 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045708 Fup NA 0.5846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045708 Vd NA 0.4349 L/kg 1compartment NA NA Human Human +DTXSID5045706 TK.Half.Life NA 3.562 hours 1compartment NA NA Rat Human +DTXSID5045706 Css NA 0.01312 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045706 Css NA 0.08081 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045706 Css NA 0.01554 mg/L PBTK NA 50% Rat Human +DTXSID5045706 Css NA 0.06843 mg/L PBTK NA 95% Rat Human +DTXSID5045708 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045708 Fup 0.602 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045708 Vd NA 0.4414 L/kg 1compartment NA NA Human Human DTXSID5045708 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045708 TK.Half.Life NA 0.3567 hours 1compartment NA NA Human Human -DTXSID5045708 Css NA 0.01473 mg/L 3compartmentss NA 50% Human Human -DTXSID5045708 Css NA 0.1536 mg/L 3compartmentss NA 95% Human Human -DTXSID5045708 Css NA 0.01051 mg/L PBTK NA 50% Human Human -DTXSID5045708 Css NA 0.09827 mg/L PBTK NA 95% Human Human -DTXSID5045708 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045708 Fup NA 0.5846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045708 Vd NA 0.4454 L/kg 1compartment NA NA Rat Human +DTXSID5045708 TK.Half.Life NA 4.744 hours 1compartment NA NA Human Human +DTXSID5045708 Css NA 1.311 mg/L 3compartmentss NA 50% Human Human +DTXSID5045708 Css NA 8.387 mg/L 3compartmentss NA 95% Human Human +DTXSID5045708 Css NA 0.949 mg/L PBTK NA 50% Human Human +DTXSID5045708 Css NA 5.225 mg/L PBTK NA 95% Human Human +DTXSID5045708 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045708 Fup 0.602 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045708 Vd NA 0.4523 L/kg 1compartment NA NA Rat Human DTXSID5045708 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045708 TK.Half.Life NA 0.1675 hours 1compartment NA NA Rat Human -DTXSID5045708 Css NA 0.00786 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045708 Css NA 0.07247 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045708 Css NA 0.005434 mg/L PBTK NA 50% Rat Human -DTXSID5045708 Css NA 0.04483 mg/L PBTK NA 95% Rat Human -DTXSID5045750 Clint NA 52.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045750 Fup NA 0.0289 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045750 Vd NA 2.57 L/kg 1compartment NA NA Human Human -DTXSID5045750 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045750 TK.Half.Life NA 11.45 hours 1compartment NA NA Human Human -DTXSID5045750 Css NA 0.5485 mg/L 3compartmentss NA 50% Human Human -DTXSID5045750 Css NA 4.071 mg/L 3compartmentss NA 95% Human Human -DTXSID5045750 Css NA 0.3733 mg/L PBTK NA 50% Human Human -DTXSID5045750 Css NA 2.628 mg/L PBTK NA 95% Human Human -DTXSID5045750 Clint NA 52.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045750 Fup NA 0.0289 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045750 Vd NA 1.968 L/kg 1compartment NA NA Rat Human -DTXSID5045750 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045750 TK.Half.Life NA 3.155 hours 1compartment NA NA Rat Human -DTXSID5045750 Css NA 0.3091 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045750 Css NA 1.902 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045750 Css NA 0.1987 mg/L PBTK NA 50% Rat Human -DTXSID5045750 Css NA 1.155 mg/L PBTK NA 95% Rat Human -DTXSID5045752 Clint NA 23.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045752 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045752 Vd NA 2.2 L/kg 1compartment NA NA Human Human +DTXSID5045708 TK.Half.Life NA 1.657 hours 1compartment NA NA Rat Human +DTXSID5045708 Css NA 0.08069 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045708 Css NA 0.473 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045708 Css NA 0.05778 mg/L PBTK NA 50% Rat Human +DTXSID5045708 Css NA 0.2798 mg/L PBTK NA 95% Rat Human +DTXSID5045752 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045752 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045752 Vd NA 1.874 L/kg 1compartment NA NA Human Human DTXSID5045752 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045752 TK.Half.Life NA 8.764 hours 1compartment NA NA Human Human -DTXSID5045752 Css NA 0.4739 mg/L 3compartmentss NA 50% Human Human -DTXSID5045752 Css NA 3.156 mg/L 3compartmentss NA 95% Human Human -DTXSID5045752 Css NA 0.319 mg/L PBTK NA 50% Human Human -DTXSID5045752 Css NA 2.048 mg/L PBTK NA 95% Human Human -DTXSID5045752 Clint NA 23.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045752 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045752 Vd NA 1.66 L/kg 1compartment NA NA Rat Human +DTXSID5045752 TK.Half.Life NA 4.827 hours 1compartment NA NA Human Human +DTXSID5045752 Css NA 0.2554 mg/L 3compartmentss NA 50% Human Human +DTXSID5045752 Css NA 1.981 mg/L 3compartmentss NA 95% Human Human +DTXSID5045752 Css NA 0.1792 mg/L PBTK NA 50% Human Human +DTXSID5045752 Css NA 1.309 mg/L PBTK NA 95% Human Human +DTXSID5045752 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045752 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045752 Vd NA 1.515 L/kg 1compartment NA NA Rat Human DTXSID5045752 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045752 TK.Half.Life NA 2.683 hours 1compartment NA NA Rat Human -DTXSID5045752 Css NA 0.2633 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045752 Css NA 1.394 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045752 Css NA 0.1689 mg/L PBTK NA 50% Rat Human -DTXSID5045752 Css NA 0.8719 mg/L PBTK NA 95% Rat Human -DTXSID5045756 Clint NA 0.9041 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045756 Fup NA 0.9555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045756 Vd NA 1.338 L/kg 1compartment NA NA Human Human -DTXSID5045756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045756 TK.Half.Life NA 3.903 hours 1compartment NA NA Human Human -DTXSID5045756 Css NA 0.3286 mg/L 3compartmentss NA 50% Human Human -DTXSID5045756 Css NA 2 mg/L 3compartmentss NA 95% Human Human -DTXSID5045756 Css NA 0.2978 mg/L PBTK NA 50% Human Human -DTXSID5045756 Css NA 1.396 mg/L PBTK NA 95% Human Human -DTXSID5045756 Clint NA 0.9041 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045756 Fup NA 0.9555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045756 Vd NA 1.352 L/kg 1compartment NA NA Rat Human +DTXSID5045752 TK.Half.Life NA 1.916 hours 1compartment NA NA Rat Human +DTXSID5045752 Css NA 0.03269 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045752 Css NA 0.1963 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045752 Css NA 0.02259 mg/L PBTK NA 50% Rat Human +DTXSID5045752 Css NA 0.1254 mg/L PBTK NA 95% Rat Human +DTXSID5045756 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045756 Fup 0.672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045756 Vd NA 1.239 L/kg 1compartment NA NA Human Human +DTXSID5045756 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5045756 TK.Half.Life NA 12.08 hours 1compartment NA NA Human Human +DTXSID5045756 Css NA 1.009 mg/L 3compartmentss NA 50% Human Human +DTXSID5045756 Css NA 6.862 mg/L 3compartmentss NA 95% Human Human +DTXSID5045756 Css NA 0.8902 mg/L PBTK NA 50% Human Human +DTXSID5045756 Css NA 4.497 mg/L PBTK NA 95% Human Human +DTXSID5045756 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045756 Fup 0.672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045756 Vd NA 1.233 L/kg 1compartment NA NA Rat Human DTXSID5045756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045756 TK.Half.Life NA 1.865 hours 1compartment NA NA Rat Human -DTXSID5045756 Css NA 0.1198 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045756 Css NA 0.7384 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045756 Css NA 0.1079 mg/L PBTK NA 50% Rat Human -DTXSID5045756 Css NA 0.4688 mg/L PBTK NA 95% Rat Human -DTXSID5045758 Clint NA 20.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045758 Fup NA 0.3496 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045758 Vd NA 2.428 L/kg 1compartment NA NA Human Human +DTXSID5045756 TK.Half.Life NA 4.058 hours 1compartment NA NA Rat Human +DTXSID5045756 Css NA 0.0603 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045756 Css NA 0.3991 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045756 Css NA 0.05361 mg/L PBTK NA 50% Rat Human +DTXSID5045756 Css NA 0.2514 mg/L PBTK NA 95% Rat Human +DTXSID5045758 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045758 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045758 Vd NA 0.5754 L/kg 1compartment NA NA Human Human DTXSID5045758 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045758 TK.Half.Life NA 2.217 hours 1compartment NA NA Human Human -DTXSID5045758 Css NA 0.03717 mg/L 3compartmentss NA 50% Human Human -DTXSID5045758 Css NA 0.3067 mg/L 3compartmentss NA 95% Human Human -DTXSID5045758 Css NA 0.04062 mg/L PBTK NA 50% Human Human -DTXSID5045758 Css NA 0.2653 mg/L PBTK NA 95% Human Human -DTXSID5045758 Clint NA 20.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045758 Fup NA 0.3496 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045758 Vd NA 2.397 L/kg 1compartment NA NA Rat Human +DTXSID5045758 TK.Half.Life NA 1.325 hours 1compartment NA NA Human Human +DTXSID5045758 Css NA 0.1958 mg/L 3compartmentss NA 50% Human Human +DTXSID5045758 Css NA 1.246 mg/L 3compartmentss NA 95% Human Human +DTXSID5045758 Css NA 0.1403 mg/L PBTK NA 50% Human Human +DTXSID5045758 Css NA 0.7979 mg/L PBTK NA 95% Human Human +DTXSID5045758 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045758 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045758 Vd NA 0.5818 L/kg 1compartment NA NA Rat Human DTXSID5045758 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045758 TK.Half.Life NA 1.199 hours 1compartment NA NA Rat Human -DTXSID5045758 Css NA 0.01899 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045758 Css NA 0.1286 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045758 Css NA 0.02076 mg/L PBTK NA 50% Rat Human -DTXSID5045758 Css NA 0.1094 mg/L PBTK NA 95% Rat Human -DTXSID5045831 Clint NA 0.6442 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5045758 TK.Half.Life NA 0.7584 hours 1compartment NA NA Rat Human +DTXSID5045758 Css NA 0.02332 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045758 Css NA 0.107 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045758 Css NA 0.01652 mg/L PBTK NA 50% Rat Human +DTXSID5045758 Css NA 0.0677 mg/L PBTK NA 95% Rat Human +DTXSID5045831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5045831 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5045831 Vd NA 0.1929 L/kg 1compartment NA NA Human Human -DTXSID5045831 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID5045831 TK.Half.Life NA 59.86 hours 1compartment NA NA Human Human -DTXSID5045831 Css NA 53.82 mg/L 3compartmentss NA 50% Human Human -DTXSID5045831 Css NA 350.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5045831 Css NA 31.56 mg/L PBTK NA 50% Human Human -DTXSID5045831 Css NA 204 mg/L PBTK NA 95% Human Human -DTXSID5045831 Clint NA 0.6442 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5045831 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5045831 TK.Half.Life NA 3.501 hours 1compartment NA NA Human Human +DTXSID5045831 Css NA 3.24 mg/L 3compartmentss NA 50% Human Human +DTXSID5045831 Css NA 32.47 mg/L 3compartmentss NA 95% Human Human +DTXSID5045831 Css NA 1.899 mg/L PBTK NA 50% Human Human +DTXSID5045831 Css NA 18.77 mg/L PBTK NA 95% Human Human +DTXSID5045831 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5045831 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5045831 Vd NA 0.1837 L/kg 1compartment NA NA Rat Human -DTXSID5045831 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5045831 TK.Half.Life NA 26.54 hours 1compartment NA NA Rat Human -DTXSID5045831 Css NA 21.55 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045831 Css NA 121.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045831 Css NA 11.75 mg/L PBTK NA 50% Rat Human -DTXSID5045831 Css NA 65.66 mg/L PBTK NA 95% Rat Human +DTXSID5045831 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5045831 TK.Half.Life NA 2.23 hours 1compartment NA NA Rat Human +DTXSID5045831 Css NA 0.4288 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045831 Css NA 3.557 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045831 Css NA 0.2419 mg/L PBTK NA 50% Rat Human +DTXSID5045831 Css NA 1.991 mg/L PBTK NA 95% Rat Human DTXSID5045833 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5045833 Fup NA 0.9055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045833 Vd NA 0.6382 L/kg 1compartment NA NA Human Human +DTXSID5045833 Vd NA 0.6584 L/kg 1compartment NA NA Human Human DTXSID5045833 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045833 TK.Half.Life NA 4.56 hours 1compartment NA NA Human Human -DTXSID5045833 Css NA 0.9476 mg/L 3compartmentss NA 50% Human Human -DTXSID5045833 Css NA 5.262 mg/L 3compartmentss NA 95% Human Human -DTXSID5045833 Css NA 0.7605 mg/L PBTK NA 50% Human Human -DTXSID5045833 Css NA 3.402 mg/L PBTK NA 95% Human Human +DTXSID5045833 TK.Half.Life NA 4.706 hours 1compartment NA NA Human Human +DTXSID5045833 Css NA 0.8121 mg/L 3compartmentss NA 50% Human Human +DTXSID5045833 Css NA 4.383 mg/L 3compartmentss NA 95% Human Human +DTXSID5045833 Css NA 0.6558 mg/L PBTK NA 50% Human Human +DTXSID5045833 Css NA 2.813 mg/L PBTK NA 95% Human Human DTXSID5045833 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5045833 Fup NA 0.9055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045833 Vd NA 0.6899 L/kg 1compartment NA NA Rat Human +DTXSID5045833 Vd NA 0.7061 L/kg 1compartment NA NA Rat Human DTXSID5045833 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045833 TK.Half.Life NA 1.68 hours 1compartment NA NA Rat Human -DTXSID5045833 Css NA 0.246 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045833 Css NA 1.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045833 Css NA 0.1909 mg/L PBTK NA 50% Rat Human -DTXSID5045833 Css NA 0.7947 mg/L PBTK NA 95% Rat Human -DTXSID5045835 Clint NA 3.071 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045835 Fup NA 0.16 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045835 Vd NA 0.3568 L/kg 1compartment NA NA Human Human +DTXSID5045833 TK.Half.Life NA 1.719 hours 1compartment NA NA Rat Human +DTXSID5045833 Css NA 0.0154 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045833 Css NA 0.1065 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045833 Css NA 0.01194 mg/L PBTK NA 50% Rat Human +DTXSID5045833 Css NA 0.06993 mg/L PBTK NA 95% Rat Human +DTXSID5045835 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045835 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045835 Vd NA 0.6003 L/kg 1compartment NA NA Human Human DTXSID5045835 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045835 TK.Half.Life NA 2.587 hours 1compartment NA NA Human Human -DTXSID5045835 Css NA 0.9788 mg/L 3compartmentss NA 50% Human Human -DTXSID5045835 Css NA 5.533 mg/L 3compartmentss NA 95% Human Human -DTXSID5045835 Css NA 0.6219 mg/L PBTK NA 50% Human Human -DTXSID5045835 Css NA 3.325 mg/L PBTK NA 95% Human Human -DTXSID5045835 Clint NA 3.071 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045835 Fup NA 0.16 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045835 Vd NA 0.3383 L/kg 1compartment NA NA Rat Human +DTXSID5045835 TK.Half.Life NA 1.549 hours 1compartment NA NA Human Human +DTXSID5045835 Css NA 0.2 mg/L 3compartmentss NA 50% Human Human +DTXSID5045835 Css NA 1.254 mg/L 3compartmentss NA 95% Human Human +DTXSID5045835 Css NA 0.1395 mg/L PBTK NA 50% Human Human +DTXSID5045835 Css NA 0.8342 mg/L PBTK NA 95% Human Human +DTXSID5045835 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045835 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045835 Vd NA 0.5439 L/kg 1compartment NA NA Rat Human DTXSID5045835 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045835 TK.Half.Life NA 1.405 hours 1compartment NA NA Rat Human -DTXSID5045835 Css NA 0.4752 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045835 Css NA 1.927 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045835 Css NA 0.2846 mg/L PBTK NA 50% Rat Human -DTXSID5045835 Css NA 1.087 mg/L PBTK NA 95% Rat Human -DTXSID5045839 Clint NA 1118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045839 Fup NA 0.4083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045839 Vd NA 0.4301 L/kg 1compartment NA NA Human Human -DTXSID5045839 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045839 TK.Half.Life NA 0.3318 hours 1compartment NA NA Human Human -DTXSID5045839 Css NA 0.0008101 mg/L 3compartmentss NA 50% Human Human -DTXSID5045839 Css NA 0.006852 mg/L 3compartmentss NA 95% Human Human -DTXSID5045839 Css NA 0.0005683 mg/L PBTK NA 50% Human Human -DTXSID5045839 Css NA 0.004484 mg/L PBTK NA 95% Human Human -DTXSID5045839 Clint NA 1118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045839 Fup NA 0.4083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045839 Vd NA 0.4554 L/kg 1compartment NA NA Rat Human -DTXSID5045839 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045839 TK.Half.Life NA 0.1527 hours 1compartment NA NA Rat Human -DTXSID5045839 Css NA 0.0004458 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045839 Css NA 0.003137 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045839 Css NA 0.0002987 mg/L PBTK NA 50% Rat Human -DTXSID5045839 Css NA 0.001933 mg/L PBTK NA 95% Rat Human +DTXSID5045835 TK.Half.Life NA 0.792 hours 1compartment NA NA Rat Human +DTXSID5045835 Css NA 0.008718 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045835 Css NA 0.06576 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045835 Css NA 0.00602 mg/L PBTK NA 50% Rat Human +DTXSID5045835 Css NA 0.04093 mg/L PBTK NA 95% Rat Human DTXSID5045881 Clint NA 439.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5045881 Fup NA 0.1539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045881 Vd NA 1.437 L/kg 1compartment NA NA Human Human +DTXSID5045881 Vd NA 1.405 L/kg 1compartment NA NA Human Human DTXSID5045881 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045881 TK.Half.Life NA 1.006 hours 1compartment NA NA Human Human -DTXSID5045881 Css NA 0.005442 mg/L 3compartmentss NA 50% Human Human -DTXSID5045881 Css NA 0.05034 mg/L 3compartmentss NA 95% Human Human -DTXSID5045881 Css NA 0.004444 mg/L PBTK NA 50% Human Human -DTXSID5045881 Css NA 0.03521 mg/L PBTK NA 95% Human Human +DTXSID5045881 TK.Half.Life NA 0.9932 hours 1compartment NA NA Human Human +DTXSID5045881 Css NA 0.0007176 mg/L 3compartmentss NA 50% Human Human +DTXSID5045881 Css NA 0.02265 mg/L 3compartmentss NA 95% Human Human +DTXSID5045881 Css NA 0.0005775 mg/L PBTK NA 50% Human Human +DTXSID5045881 Css NA 0.01574 mg/L PBTK NA 95% Human Human DTXSID5045881 Clint NA 439.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5045881 Fup NA 0.1539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045881 Vd NA 1.4 L/kg 1compartment NA NA Rat Human +DTXSID5045881 Vd NA 1.368 L/kg 1compartment NA NA Rat Human DTXSID5045881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045881 TK.Half.Life NA 0.4438 hours 1compartment NA NA Rat Human -DTXSID5045881 Css NA 0.003054 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045881 Css NA 0.0225 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045881 Css NA 0.002408 mg/L PBTK NA 50% Rat Human -DTXSID5045881 Css NA 0.01533 mg/L PBTK NA 95% Rat Human -DTXSID5045883 Clint NA 7.554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045883 Fup NA 0.7088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045883 Vd NA 2.175 L/kg 1compartment NA NA Human Human -DTXSID5045883 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045883 TK.Half.Life NA 2.368 hours 1compartment NA NA Human Human -DTXSID5045883 Css NA 0.06908 mg/L 3compartmentss NA 50% Human Human -DTXSID5045883 Css NA 0.6666 mg/L 3compartmentss NA 95% Human Human -DTXSID5045883 Css NA 0.06982 mg/L PBTK NA 50% Human Human -DTXSID5045883 Css NA 0.5044 mg/L PBTK NA 95% Human Human -DTXSID5045883 Clint NA 7.554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045883 Fup NA 0.7088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045883 Vd NA 2.207 L/kg 1compartment NA NA Rat Human +DTXSID5045881 TK.Half.Life NA 0.4379 hours 1compartment NA NA Rat Human +DTXSID5045881 Css NA 5.174e-06 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045881 Css NA 0.0001696 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045881 Css NA 4.053e-06 mg/L PBTK NA 50% Rat Human +DTXSID5045881 Css NA 0.0001159 mg/L PBTK NA 95% Rat Human +DTXSID5045883 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045883 Fup 0.733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045883 Vd NA 2.672 L/kg 1compartment NA NA Human Human +DTXSID5045883 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5045883 TK.Half.Life NA 23.62 hours 1compartment NA NA Human Human +DTXSID5045883 Css NA 0.663 mg/L 3compartmentss NA 50% Human Human +DTXSID5045883 Css NA 5.345 mg/L 3compartmentss NA 95% Human Human +DTXSID5045883 Css NA 0.7413 mg/L PBTK NA 50% Human Human +DTXSID5045883 Css NA 3.78 mg/L PBTK NA 95% Human Human +DTXSID5045883 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045883 Fup 0.733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045883 Vd NA 2.716 L/kg 1compartment NA NA Rat Human DTXSID5045883 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045883 TK.Half.Life NA 1.311 hours 1compartment NA NA Rat Human -DTXSID5045883 Css NA 0.03244 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045883 Css NA 0.2986 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045883 Css NA 0.03356 mg/L PBTK NA 50% Rat Human -DTXSID5045883 Css NA 0.2002 mg/L PBTK NA 95% Rat Human -DTXSID5045885 Clint NA 1.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045885 Fup NA 0.2043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045885 Vd NA 0.3608 L/kg 1compartment NA NA Human Human +DTXSID5045883 TK.Half.Life NA 8.175 hours 1compartment NA NA Rat Human +DTXSID5045883 Css NA 0.01685 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045883 Css NA 0.1532 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045883 Css NA 0.0189 mg/L PBTK NA 50% Rat Human +DTXSID5045883 Css NA 0.1096 mg/L PBTK NA 95% Rat Human +DTXSID5045885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045885 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045885 Vd NA 0.3322 L/kg 1compartment NA NA Human Human DTXSID5045885 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045885 TK.Half.Life NA 3.794 hours 1compartment NA NA Human Human -DTXSID5045885 Css NA 1.264 mg/L 3compartmentss NA 50% Human Human -DTXSID5045885 Css NA 5.401 mg/L 3compartmentss NA 95% Human Human -DTXSID5045885 Css NA 0.838 mg/L PBTK NA 50% Human Human -DTXSID5045885 Css NA 3.325 mg/L PBTK NA 95% Human Human -DTXSID5045885 Clint NA 1.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045885 Fup NA 0.2043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045885 Vd NA 0.3608 L/kg 1compartment NA NA Rat Human +DTXSID5045885 TK.Half.Life NA 0.5771 hours 1compartment NA NA Human Human +DTXSID5045885 Css NA 0.1184 mg/L 3compartmentss NA 50% Human Human +DTXSID5045885 Css NA 0.8346 mg/L 3compartmentss NA 95% Human Human +DTXSID5045885 Css NA 0.07715 mg/L PBTK NA 50% Human Human +DTXSID5045885 Css NA 0.525 mg/L PBTK NA 95% Human Human +DTXSID5045885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045885 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045885 Vd NA 0.333 L/kg 1compartment NA NA Rat Human DTXSID5045885 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045885 TK.Half.Life NA 1.951 hours 1compartment NA NA Rat Human -DTXSID5045885 Css NA 0.5417 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045885 Css NA 1.826 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045885 Css NA 0.34 mg/L PBTK NA 50% Rat Human -DTXSID5045885 Css NA 1.047 mg/L PBTK NA 95% Rat Human -DTXSID5045887 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045887 Fup NA 0.3177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045887 Vd NA 0.4153 L/kg 1compartment NA NA Human Human +DTXSID5045885 TK.Half.Life NA 0.3219 hours 1compartment NA NA Rat Human +DTXSID5045885 Css NA 0.01516 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045885 Css NA 0.08159 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045885 Css NA 0.009662 mg/L PBTK NA 50% Rat Human +DTXSID5045885 Css NA 0.04988 mg/L PBTK NA 95% Rat Human +DTXSID5045887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045887 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045887 Vd NA 0.4145 L/kg 1compartment NA NA Human Human DTXSID5045887 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045887 TK.Half.Life NA 8.457 hours 1compartment NA NA Human Human -DTXSID5045887 Css NA 2.407 mg/L 3compartmentss NA 50% Human Human -DTXSID5045887 Css NA 9.442 mg/L 3compartmentss NA 95% Human Human -DTXSID5045887 Css NA 1.68 mg/L PBTK NA 50% Human Human -DTXSID5045887 Css NA 5.903 mg/L PBTK NA 95% Human Human -DTXSID5045887 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045887 Fup NA 0.3177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045887 Vd NA 0.4176 L/kg 1compartment NA NA Rat Human +DTXSID5045887 TK.Half.Life NA 0.534 hours 1compartment NA NA Human Human +DTXSID5045887 Css NA 0.0289 mg/L 3compartmentss NA 50% Human Human +DTXSID5045887 Css NA 0.2676 mg/L 3compartmentss NA 95% Human Human +DTXSID5045887 Css NA 0.02002 mg/L PBTK NA 50% Human Human +DTXSID5045887 Css NA 0.1738 mg/L PBTK NA 95% Human Human +DTXSID5045887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045887 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045887 Vd NA 0.4172 L/kg 1compartment NA NA Rat Human DTXSID5045887 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045887 TK.Half.Life NA 2.898 hours 1compartment NA NA Rat Human -DTXSID5045887 Css NA 0.6627 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045887 Css NA 2.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045887 Css NA 0.44 mg/L PBTK NA 50% Rat Human -DTXSID5045887 Css NA 1.308 mg/L PBTK NA 95% Rat Human -DTXSID5045889 Clint NA 372.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045889 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045889 Vd NA 15.49 L/kg 1compartment NA NA Human Human -DTXSID5045889 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5045889 TK.Half.Life NA 31.75 hours 1compartment NA NA Human Human -DTXSID5045889 Css NA 0.0863 mg/L 3compartmentss NA 50% Human Human -DTXSID5045889 Css NA 0.4942 mg/L 3compartmentss NA 95% Human Human -DTXSID5045889 Css NA 0.1442 mg/L PBTK NA 50% Human Human -DTXSID5045889 Css NA 0.7745 mg/L PBTK NA 95% Human Human -DTXSID5045889 Clint NA 372.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045889 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045889 Vd NA 12.44 L/kg 1compartment NA NA Rat Human -DTXSID5045889 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5045889 TK.Half.Life NA 5.536 hours 1compartment NA NA Rat Human -DTXSID5045889 Css NA 0.04556 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045889 Css NA 0.1983 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045889 Css NA 0.07776 mg/L PBTK NA 50% Rat Human -DTXSID5045889 Css NA 0.3524 mg/L PBTK NA 95% Rat Human -DTXSID5045910 Clint NA 17.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045910 Fup NA 0.1135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045910 Vd NA 2.8 L/kg 1compartment NA NA Human Human +DTXSID5045887 TK.Half.Life NA 0.2829 hours 1compartment NA NA Rat Human +DTXSID5045887 Css NA 0.0002603 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045887 Css NA 0.002561 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045887 Css NA 0.0001738 mg/L PBTK NA 50% Rat Human +DTXSID5045887 Css NA 0.001593 mg/L PBTK NA 95% Rat Human +DTXSID5045889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045889 Fup 0.0087 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045889 Vd NA 3.794 L/kg 1compartment NA NA Human Human +DTXSID5045889 Days.Css NA 20 Days PBTK NA NA Human Human +DTXSID5045889 TK.Half.Life NA 115.3 hours 1compartment NA NA Human Human +DTXSID5045889 Css NA 3.272 mg/L 3compartmentss NA 50% Human Human +DTXSID5045889 Css NA 19.78 mg/L 3compartmentss NA 95% Human Human +DTXSID5045889 Css NA 2.397 mg/L PBTK NA 50% Human Human +DTXSID5045889 Css NA 14.4 mg/L PBTK NA 95% Human Human +DTXSID5045889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045889 Fup 0.0087 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045889 Vd NA 2.864 L/kg 1compartment NA NA Rat Human +DTXSID5045889 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID5045889 TK.Half.Life NA 15.84 hours 1compartment NA NA Rat Human +DTXSID5045889 Css NA 0.4282 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045889 Css NA 2.088 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045889 Css NA 0.3116 mg/L PBTK NA 50% Rat Human +DTXSID5045889 Css NA 1.552 mg/L PBTK NA 95% Rat Human +DTXSID5045910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045910 Fup 0.095 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045910 Vd NA 2.517 L/kg 1compartment NA NA Human Human DTXSID5045910 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045910 TK.Half.Life NA 6.145 hours 1compartment NA NA Human Human -DTXSID5045910 Css NA 0.1966 mg/L 3compartmentss NA 50% Human Human -DTXSID5045910 Css NA 1.627 mg/L 3compartmentss NA 95% Human Human -DTXSID5045910 Css NA 0.1672 mg/L PBTK NA 50% Human Human -DTXSID5045910 Css NA 1.173 mg/L PBTK NA 95% Human Human -DTXSID5045910 Clint NA 17.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045910 Fup NA 0.1135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045910 Vd NA 2.601 L/kg 1compartment NA NA Rat Human +DTXSID5045910 TK.Half.Life NA 11.7 hours 1compartment NA NA Human Human +DTXSID5045910 Css NA 0.5284 mg/L 3compartmentss NA 50% Human Human +DTXSID5045910 Css NA 3.401 mg/L 3compartmentss NA 95% Human Human +DTXSID5045910 Css NA 0.3628 mg/L PBTK NA 50% Human Human +DTXSID5045910 Css NA 2.23 mg/L PBTK NA 95% Human Human +DTXSID5045910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045910 Fup 0.095 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045910 Vd NA 1.895 L/kg 1compartment NA NA Rat Human DTXSID5045910 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045910 TK.Half.Life NA 2.989 hours 1compartment NA NA Rat Human -DTXSID5045910 Css NA 0.1053 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045910 Css NA 0.6977 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045910 Css NA 0.08702 mg/L PBTK NA 50% Rat Human -DTXSID5045910 Css NA 0.4811 mg/L PBTK NA 95% Rat Human -DTXSID5045914 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045914 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045914 Vd NA 0.6719 L/kg 1compartment NA NA Human Human +DTXSID5045910 TK.Half.Life NA 3.029 hours 1compartment NA NA Rat Human +DTXSID5045910 Css NA 0.06787 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045910 Css NA 0.3602 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045910 Css NA 0.0459 mg/L PBTK NA 50% Rat Human +DTXSID5045910 Css NA 0.2357 mg/L PBTK NA 95% Rat Human +DTXSID5045914 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045914 Fup 0.926 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045914 Vd NA 0.7055 L/kg 1compartment NA NA Human Human DTXSID5045914 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045914 TK.Half.Life NA 4.348 hours 1compartment NA NA Human Human -DTXSID5045914 Css NA 0.8534 mg/L 3compartmentss NA 50% Human Human -DTXSID5045914 Css NA 5.583 mg/L 3compartmentss NA 95% Human Human -DTXSID5045914 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID5045914 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID5045914 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045914 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045914 Vd NA 0.7275 L/kg 1compartment NA NA Rat Human +DTXSID5045914 TK.Half.Life NA 4.93 hours 1compartment NA NA Human Human +DTXSID5045914 Css NA 0.755 mg/L 3compartmentss NA 50% Human Human +DTXSID5045914 Css NA 2.855 mg/L 3compartmentss NA 95% Human Human +DTXSID5045914 Css NA 0.6218 mg/L PBTK NA 50% Human Human +DTXSID5045914 Css NA 1.977 mg/L PBTK NA 95% Human Human +DTXSID5045914 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045914 Fup 0.926 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045914 Vd NA 0.7469 L/kg 1compartment NA NA Rat Human DTXSID5045914 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045914 TK.Half.Life NA 1.604 hours 1compartment NA NA Rat Human -DTXSID5045914 Css NA 0.2145 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045914 Css NA 1.342 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045914 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID5045914 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5045916 Clint NA 731.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045916 Fup NA 0.0316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045916 Vd NA 2.285 L/kg 1compartment NA NA Human Human +DTXSID5045914 TK.Half.Life NA 1.779 hours 1compartment NA NA Rat Human +DTXSID5045914 Css NA 0.01375 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045914 Css NA 0.07084 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045914 Css NA 0.01093 mg/L PBTK NA 50% Rat Human +DTXSID5045914 Css NA 0.05122 mg/L PBTK NA 95% Rat Human +DTXSID5045916 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045916 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045916 Vd NA 0.4278 L/kg 1compartment NA NA Human Human DTXSID5045916 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045916 TK.Half.Life NA 2.078 hours 1compartment NA NA Human Human -DTXSID5045916 Css NA 0.01795 mg/L 3compartmentss NA 50% Human Human -DTXSID5045916 Css NA 0.1635 mg/L 3compartmentss NA 95% Human Human -DTXSID5045916 Css NA 0.01236 mg/L PBTK NA 50% Human Human -DTXSID5045916 Css NA 0.1047 mg/L PBTK NA 95% Human Human -DTXSID5045916 Clint NA 731.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045916 Fup NA 0.0316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045916 Vd NA 1.864 L/kg 1compartment NA NA Rat Human +DTXSID5045916 TK.Half.Life NA 0.9372 hours 1compartment NA NA Human Human +DTXSID5045916 Css NA 0.2119 mg/L 3compartmentss NA 50% Human Human +DTXSID5045916 Css NA 1.694 mg/L 3compartmentss NA 95% Human Human +DTXSID5045916 Css NA 0.1345 mg/L PBTK NA 50% Human Human +DTXSID5045916 Css NA 1.026 mg/L PBTK NA 95% Human Human +DTXSID5045916 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045916 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045916 Vd NA 0.3961 L/kg 1compartment NA NA Rat Human DTXSID5045916 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045916 TK.Half.Life NA 0.7507 hours 1compartment NA NA Rat Human -DTXSID5045916 Css NA 0.01006 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045916 Css NA 0.07864 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045916 Css NA 0.006656 mg/L PBTK NA 50% Rat Human -DTXSID5045916 Css NA 0.04776 mg/L PBTK NA 95% Rat Human -DTXSID5045960 Clint NA 0.8601 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045960 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045960 Vd NA 0.3418 L/kg 1compartment NA NA Human Human -DTXSID5045960 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID5045960 TK.Half.Life NA 39.14 hours 1compartment NA NA Human Human -DTXSID5045960 Css NA 19.68 mg/L 3compartmentss NA 50% Human Human -DTXSID5045960 Css NA 133.2 mg/L 3compartmentss NA 95% Human Human -DTXSID5045960 Css NA 11.73 mg/L PBTK NA 50% Human Human -DTXSID5045960 Css NA 76.58 mg/L PBTK NA 95% Human Human -DTXSID5045960 Clint NA 0.8601 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045960 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045960 Vd NA 0.2842 L/kg 1compartment NA NA Rat Human -DTXSID5045960 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5045960 TK.Half.Life NA 15.9 hours 1compartment NA NA Rat Human -DTXSID5045960 Css NA 8.182 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045960 Css NA 47.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045960 Css NA 4.53 mg/L PBTK NA 50% Rat Human -DTXSID5045960 Css NA 25.75 mg/L PBTK NA 95% Rat Human -DTXSID5045962 Clint NA 6.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045962 Fup NA 0.1856 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045962 Vd NA 1.222 L/kg 1compartment NA NA Human Human -DTXSID5045962 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5045962 TK.Half.Life NA 5.104 hours 1compartment NA NA Human Human -DTXSID5045962 Css NA 0.4416 mg/L 3compartmentss NA 50% Human Human -DTXSID5045962 Css NA 2.501 mg/L 3compartmentss NA 95% Human Human -DTXSID5045962 Css NA 0.3097 mg/L PBTK NA 50% Human Human -DTXSID5045962 Css NA 1.648 mg/L PBTK NA 95% Human Human -DTXSID5045962 Clint NA 6.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045962 Fup NA 0.1856 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045962 Vd NA 0.9793 L/kg 1compartment NA NA Rat Human -DTXSID5045962 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5045962 TK.Half.Life NA 2.18 hours 1compartment NA NA Rat Human -DTXSID5045962 Css NA 0.2293 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045962 Css NA 0.9397 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045962 Css NA 0.1533 mg/L PBTK NA 50% Rat Human -DTXSID5045962 Css NA 0.5708 mg/L PBTK NA 95% Rat Human -DTXSID5045964 Clint NA 22.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045964 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5045964 Vd NA 3.035 L/kg 1compartment NA NA Human Human -DTXSID5045964 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID5045964 TK.Half.Life NA 48.37 hours 1compartment NA NA Human Human -DTXSID5045964 Css NA 1.936 mg/L 3compartmentss NA 50% Human Human -DTXSID5045964 Css NA 12.27 mg/L 3compartmentss NA 95% Human Human -DTXSID5045964 Css NA 1.342 mg/L PBTK NA 50% Human Human -DTXSID5045964 Css NA 8.19 mg/L PBTK NA 95% Human Human -DTXSID5045964 Clint NA 22.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045964 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5045964 Vd NA 2.275 L/kg 1compartment NA NA Rat Human -DTXSID5045964 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5045964 TK.Half.Life NA 7.509 hours 1compartment NA NA Rat Human -DTXSID5045964 Css NA 1.081 mg/L 3compartmentss NA 50% Rat Human -DTXSID5045964 Css NA 5.578 mg/L 3compartmentss NA 95% Rat Human -DTXSID5045964 Css NA 0.7158 mg/L PBTK NA 50% Rat Human -DTXSID5045964 Css NA 3.585 mg/L PBTK NA 95% Rat Human -DTXSID5046011 Clint NA 206.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046011 Fup NA 0.2451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046011 Vd NA 3.038 L/kg 1compartment NA NA Human Human -DTXSID5046011 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046011 TK.Half.Life NA 1.427 hours 1compartment NA NA Human Human -DTXSID5046011 Css NA 0.003059 mg/L 3compartmentss NA 50% Human Human -DTXSID5046011 Css NA 0.02826 mg/L 3compartmentss NA 95% Human Human -DTXSID5046011 Css NA 0.003776 mg/L PBTK NA 50% Human Human -DTXSID5046011 Css NA 0.02702 mg/L PBTK NA 95% Human Human -DTXSID5046011 Clint NA 206.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046011 Fup NA 0.2451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046011 Vd NA 3 L/kg 1compartment NA NA Rat Human -DTXSID5046011 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046011 TK.Half.Life NA 0.646 hours 1compartment NA NA Rat Human -DTXSID5046011 Css NA 0.001622 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046011 Css NA 0.01241 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046011 Css NA 0.002021 mg/L PBTK NA 50% Rat Human -DTXSID5046011 Css NA 0.01172 mg/L PBTK NA 95% Rat Human +DTXSID5045916 TK.Half.Life NA 0.5016 hours 1compartment NA NA Rat Human +DTXSID5045916 Css NA 0.02759 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045916 Css NA 0.1752 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045916 Css NA 0.01698 mg/L PBTK NA 50% Rat Human +DTXSID5045916 Css NA 0.1022 mg/L PBTK NA 95% Rat Human +DTXSID5045960 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045960 Fup 0.0419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045960 Vd NA 0.3989 L/kg 1compartment NA NA Human Human +DTXSID5045960 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5045960 TK.Half.Life NA 5.572 hours 1compartment NA NA Human Human +DTXSID5045960 Css NA 2.327 mg/L 3compartmentss NA 50% Human Human +DTXSID5045960 Css NA 15.98 mg/L 3compartmentss NA 95% Human Human +DTXSID5045960 Css NA 1.408 mg/L PBTK NA 50% Human Human +DTXSID5045960 Css NA 9.487 mg/L PBTK NA 95% Human Human +DTXSID5045960 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045960 Fup 0.0419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045960 Vd NA 0.3323 L/kg 1compartment NA NA Rat Human +DTXSID5045960 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5045960 TK.Half.Life NA 2.882 hours 1compartment NA NA Rat Human +DTXSID5045960 Css NA 0.2891 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045960 Css NA 1.377 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045960 Css NA 0.1687 mg/L PBTK NA 50% Rat Human +DTXSID5045960 Css NA 0.7826 mg/L PBTK NA 95% Rat Human +DTXSID5045962 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045962 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045962 Vd NA 1.771 L/kg 1compartment NA NA Human Human +DTXSID5045962 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID5045962 TK.Half.Life NA 45.78 hours 1compartment NA NA Human Human +DTXSID5045962 Css NA 2.604 mg/L 3compartmentss NA 50% Human Human +DTXSID5045962 Css NA 9.749 mg/L 3compartmentss NA 95% Human Human +DTXSID5045962 Css NA 2.064 mg/L PBTK NA 50% Human Human +DTXSID5045962 Css NA 6.6 mg/L PBTK NA 95% Human Human +DTXSID5045962 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045962 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045962 Vd NA 1.458 L/kg 1compartment NA NA Rat Human +DTXSID5045962 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5045962 TK.Half.Life NA 10.22 hours 1compartment NA NA Rat Human +DTXSID5045962 Css NA 0.1646 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045962 Css NA 0.5239 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045962 Css NA 0.1305 mg/L PBTK NA 50% Rat Human +DTXSID5045962 Css NA 0.3398 mg/L PBTK NA 95% Rat Human +DTXSID5045964 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045964 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5045964 Vd NA 3.085 L/kg 1compartment NA NA Human Human +DTXSID5045964 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID5045964 TK.Half.Life NA 67.76 hours 1compartment NA NA Human Human +DTXSID5045964 Css NA 2.617 mg/L 3compartmentss NA 50% Human Human +DTXSID5045964 Css NA 16.1 mg/L 3compartmentss NA 95% Human Human +DTXSID5045964 Css NA 1.805 mg/L PBTK NA 50% Human Human +DTXSID5045964 Css NA 10.86 mg/L PBTK NA 95% Human Human +DTXSID5045964 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045964 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5045964 Vd NA 2.311 L/kg 1compartment NA NA Rat Human +DTXSID5045964 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID5045964 TK.Half.Life NA 9.703 hours 1compartment NA NA Rat Human +DTXSID5045964 Css NA 0.3391 mg/L 3compartmentss NA 50% Rat Human +DTXSID5045964 Css NA 1.93 mg/L 3compartmentss NA 95% Rat Human +DTXSID5045964 Css NA 0.2319 mg/L PBTK NA 50% Rat Human +DTXSID5045964 Css NA 1.276 mg/L PBTK NA 95% Rat Human DTXSID5046013 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5046013 Fup NA 0.775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046013 Vd NA 0.7622 L/kg 1compartment NA NA Human Human +DTXSID5046013 Vd NA 0.4838 L/kg 1compartment NA NA Human Human DTXSID5046013 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046013 TK.Half.Life NA 6.383 hours 1compartment NA NA Human Human -DTXSID5046013 Css NA 1.003 mg/L 3compartmentss NA 50% Human Human -DTXSID5046013 Css NA 6.172 mg/L 3compartmentss NA 95% Human Human -DTXSID5046013 Css NA 0.8292 mg/L PBTK NA 50% Human Human -DTXSID5046013 Css NA 4.007 mg/L PBTK NA 95% Human Human +DTXSID5046013 TK.Half.Life NA 4.039 hours 1compartment NA NA Human Human +DTXSID5046013 Css NA 0.6132 mg/L 3compartmentss NA 50% Human Human +DTXSID5046013 Css NA 3.751 mg/L 3compartmentss NA 95% Human Human +DTXSID5046013 Css NA 0.4574 mg/L PBTK NA 50% Human Human +DTXSID5046013 Css NA 2.361 mg/L PBTK NA 95% Human Human DTXSID5046013 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5046013 Fup NA 0.775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046013 Vd NA 0.7793 L/kg 1compartment NA NA Rat Human +DTXSID5046013 Vd NA 0.5135 L/kg 1compartment NA NA Rat Human DTXSID5046013 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046013 TK.Half.Life NA 2.218 hours 1compartment NA NA Rat Human -DTXSID5046013 Css NA 0.257 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046013 Css NA 1.578 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046013 Css NA 0.2063 mg/L PBTK NA 50% Rat Human -DTXSID5046013 Css NA 0.9426 mg/L PBTK NA 95% Rat Human -DTXSID5046015 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046015 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046015 Vd NA 0.4778 L/kg 1compartment NA NA Human Human +DTXSID5046013 TK.Half.Life NA 1.461 hours 1compartment NA NA Rat Human +DTXSID5046013 Css NA 0.003156 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046013 Css NA 0.02006 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046013 Css NA 0.002261 mg/L PBTK NA 50% Rat Human +DTXSID5046013 Css NA 0.01191 mg/L PBTK NA 95% Rat Human +DTXSID5046015 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046015 Fup 0.877 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046015 Vd NA 0.4469 L/kg 1compartment NA NA Human Human DTXSID5046015 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046015 TK.Half.Life NA 3.092 hours 1compartment NA NA Human Human -DTXSID5046015 Css NA 0.9342 mg/L 3compartmentss NA 50% Human Human -DTXSID5046015 Css NA 5.733 mg/L 3compartmentss NA 95% Human Human -DTXSID5046015 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID5046015 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID5046015 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046015 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046015 Vd NA 0.5067 L/kg 1compartment NA NA Rat Human +DTXSID5046015 TK.Half.Life NA 3.298 hours 1compartment NA NA Human Human +DTXSID5046015 Css NA 0.5834 mg/L 3compartmentss NA 50% Human Human +DTXSID5046015 Css NA 3.183 mg/L 3compartmentss NA 95% Human Human +DTXSID5046015 Css NA 0.4275 mg/L PBTK NA 50% Human Human +DTXSID5046015 Css NA 1.961 mg/L PBTK NA 95% Human Human +DTXSID5046015 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046015 Fup 0.877 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046015 Vd NA 0.473 L/kg 1compartment NA NA Rat Human DTXSID5046015 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046015 TK.Half.Life NA 1.117 hours 1compartment NA NA Rat Human -DTXSID5046015 Css NA 0.2375 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046015 Css NA 1.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046015 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID5046015 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5046017 Clint NA 10.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046017 Fup NA 0.0663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046017 Vd NA 1.572 L/kg 1compartment NA NA Human Human +DTXSID5046015 TK.Half.Life NA 1.189 hours 1compartment NA NA Rat Human +DTXSID5046015 Css NA 0.002984 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046015 Css NA 0.01746 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046015 Css NA 0.002112 mg/L PBTK NA 50% Rat Human +DTXSID5046015 Css NA 0.01044 mg/L PBTK NA 95% Rat Human +DTXSID5046017 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046017 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046017 Vd NA 0.4162 L/kg 1compartment NA NA Human Human DTXSID5046017 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046017 TK.Half.Life NA 10.84 hours 1compartment NA NA Human Human -DTXSID5046017 Css NA 0.9688 mg/L 3compartmentss NA 50% Human Human -DTXSID5046017 Css NA 6.606 mg/L 3compartmentss NA 95% Human Human -DTXSID5046017 Css NA 0.6308 mg/L PBTK NA 50% Human Human -DTXSID5046017 Css NA 4.074 mg/L PBTK NA 95% Human Human -DTXSID5046017 Clint NA 10.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046017 Fup NA 0.0663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046017 Vd NA 1.193 L/kg 1compartment NA NA Rat Human +DTXSID5046017 TK.Half.Life NA 0.7974 hours 1compartment NA NA Human Human +DTXSID5046017 Css NA 0.1567 mg/L 3compartmentss NA 50% Human Human +DTXSID5046017 Css NA 1.201 mg/L 3compartmentss NA 95% Human Human +DTXSID5046017 Css NA 0.1014 mg/L PBTK NA 50% Human Human +DTXSID5046017 Css NA 0.7316 mg/L PBTK NA 95% Human Human +DTXSID5046017 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046017 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046017 Vd NA 0.4027 L/kg 1compartment NA NA Rat Human DTXSID5046017 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046017 TK.Half.Life NA 4.123 hours 1compartment NA NA Rat Human -DTXSID5046017 Css NA 0.5381 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046017 Css NA 2.662 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046017 Css NA 0.3303 mg/L PBTK NA 50% Rat Human -DTXSID5046017 Css NA 1.558 mg/L PBTK NA 95% Rat Human -DTXSID5046019 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046019 Fup NA 0.5797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046019 Vd NA 0.5289 L/kg 1compartment NA NA Human Human +DTXSID5046017 TK.Half.Life NA 0.437 hours 1compartment NA NA Rat Human +DTXSID5046017 Css NA 0.02036 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046017 Css NA 0.1207 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046017 Css NA 0.01282 mg/L PBTK NA 50% Rat Human +DTXSID5046017 Css NA 0.07262 mg/L PBTK NA 95% Rat Human +DTXSID5046019 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046019 Fup 0.796 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046019 Vd NA 0.5487 L/kg 1compartment NA NA Human Human DTXSID5046019 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046019 TK.Half.Life NA 5.904 hours 1compartment NA NA Human Human -DTXSID5046019 Css NA 1.345 mg/L 3compartmentss NA 50% Human Human -DTXSID5046019 Css NA 8.852 mg/L 3compartmentss NA 95% Human Human -DTXSID5046019 Css NA 1.015 mg/L PBTK NA 50% Human Human -DTXSID5046019 Css NA 5.488 mg/L PBTK NA 95% Human Human -DTXSID5046019 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046019 Fup NA 0.5797 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046019 Vd NA 0.5519 L/kg 1compartment NA NA Rat Human +DTXSID5046019 TK.Half.Life NA 4.463 hours 1compartment NA NA Human Human +DTXSID5046019 Css NA 0.5906 mg/L 3compartmentss NA 50% Human Human +DTXSID5046019 Css NA 3.421 mg/L 3compartmentss NA 95% Human Human +DTXSID5046019 Css NA 0.4496 mg/L PBTK NA 50% Human Human +DTXSID5046019 Css NA 2.149 mg/L PBTK NA 95% Human Human +DTXSID5046019 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046019 Fup 0.796 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046019 Vd NA 0.5647 L/kg 1compartment NA NA Rat Human DTXSID5046019 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046019 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human -DTXSID5046019 Css NA 0.3562 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046019 Css NA 2.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046019 Css NA 0.256 mg/L PBTK NA 50% Rat Human -DTXSID5046019 Css NA 1.267 mg/L PBTK NA 95% Rat Human -DTXSID5046061 Clint NA 55.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046061 Fup NA 0.0794 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046061 Vd NA 0.616 L/kg 1compartment NA NA Human Human +DTXSID5046019 TK.Half.Life NA 1.564 hours 1compartment NA NA Rat Human +DTXSID5046019 Css NA 0.003018 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046019 Css NA 0.01944 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046019 Css NA 0.002218 mg/L PBTK NA 50% Rat Human +DTXSID5046019 Css NA 0.01176 mg/L PBTK NA 95% Rat Human +DTXSID5046061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046061 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046061 Vd NA 0.3978 L/kg 1compartment NA NA Human Human DTXSID5046061 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046061 TK.Half.Life NA 1.075 hours 1compartment NA NA Human Human -DTXSID5046061 Css NA 0.1502 mg/L 3compartmentss NA 50% Human Human -DTXSID5046061 Css NA 1.27 mg/L 3compartmentss NA 95% Human Human -DTXSID5046061 Css NA 0.09372 mg/L PBTK NA 50% Human Human -DTXSID5046061 Css NA 0.7563 mg/L PBTK NA 95% Human Human -DTXSID5046061 Clint NA 55.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046061 Fup NA 0.0794 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046061 Vd NA 0.5068 L/kg 1compartment NA NA Rat Human +DTXSID5046061 TK.Half.Life NA 0.8429 hours 1compartment NA NA Human Human +DTXSID5046061 Css NA 0.1986 mg/L 3compartmentss NA 50% Human Human +DTXSID5046061 Css NA 1.592 mg/L 3compartmentss NA 95% Human Human +DTXSID5046061 Css NA 0.1252 mg/L PBTK NA 50% Human Human +DTXSID5046061 Css NA 0.9569 mg/L PBTK NA 95% Human Human +DTXSID5046061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046061 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046061 Vd NA 0.3627 L/kg 1compartment NA NA Rat Human DTXSID5046061 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046061 TK.Half.Life NA 0.4854 hours 1compartment NA NA Rat Human -DTXSID5046061 Css NA 0.0859 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046061 Css NA 0.5719 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046061 Css NA 0.05025 mg/L PBTK NA 50% Rat Human -DTXSID5046061 Css NA 0.3243 mg/L PBTK NA 95% Rat Human -DTXSID5046063 Clint NA 16.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046063 Fup NA 0.3861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046063 Vd NA 3.106 L/kg 1compartment NA NA Human Human +DTXSID5046061 TK.Half.Life NA 0.4401 hours 1compartment NA NA Rat Human +DTXSID5046061 Css NA 0.02569 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046061 Css NA 0.1555 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046061 Css NA 0.01569 mg/L PBTK NA 50% Rat Human +DTXSID5046061 Css NA 0.09157 mg/L PBTK NA 95% Rat Human +DTXSID5046063 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046063 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046063 Vd NA 3.165 L/kg 1compartment NA NA Human Human DTXSID5046063 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046063 TK.Half.Life NA 3.37 hours 1compartment NA NA Human Human -DTXSID5046063 Css NA 0.05248 mg/L 3compartmentss NA 50% Human Human -DTXSID5046063 Css NA 0.4085 mg/L 3compartmentss NA 95% Human Human -DTXSID5046063 Css NA 0.05564 mg/L PBTK NA 50% Human Human -DTXSID5046063 Css NA 0.3467 mg/L PBTK NA 95% Human Human -DTXSID5046063 Clint NA 16.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046063 Fup NA 0.3861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046063 Vd NA 3.027 L/kg 1compartment NA NA Rat Human +DTXSID5046063 TK.Half.Life NA 7.25 hours 1compartment NA NA Human Human +DTXSID5046063 Css NA 0.1539 mg/L 3compartmentss NA 50% Human Human +DTXSID5046063 Css NA 1.03 mg/L 3compartmentss NA 95% Human Human +DTXSID5046063 Css NA 0.1595 mg/L PBTK NA 50% Human Human +DTXSID5046063 Css NA 0.8846 mg/L PBTK NA 95% Human Human +DTXSID5046063 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046063 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046063 Vd NA 3.033 L/kg 1compartment NA NA Rat Human DTXSID5046063 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046063 TK.Half.Life NA 1.706 hours 1compartment NA NA Rat Human -DTXSID5046063 Css NA 0.02696 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046063 Css NA 0.168 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046063 Css NA 0.02831 mg/L PBTK NA 50% Rat Human -DTXSID5046063 Css NA 0.1397 mg/L PBTK NA 95% Rat Human -DTXSID5046067 Clint NA 1.943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046067 Fup NA 0.2619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046067 Vd NA 0.706 L/kg 1compartment NA NA Human Human -DTXSID5046067 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046067 TK.Half.Life NA 4.539 hours 1compartment NA NA Human Human -DTXSID5046067 Css NA 0.7129 mg/L 3compartmentss NA 50% Human Human -DTXSID5046067 Css NA 3.486 mg/L 3compartmentss NA 95% Human Human -DTXSID5046067 Css NA 0.502 mg/L PBTK NA 50% Human Human -DTXSID5046067 Css NA 2.237 mg/L PBTK NA 95% Human Human -DTXSID5046067 Clint NA 1.943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046067 Fup NA 0.2619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046067 Vd NA 0.6193 L/kg 1compartment NA NA Rat Human +DTXSID5046063 TK.Half.Life NA 3.588 hours 1compartment NA NA Rat Human +DTXSID5046063 Css NA 0.01766 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046063 Css NA 0.09202 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046063 Css NA 0.01876 mg/L PBTK NA 50% Rat Human +DTXSID5046063 Css NA 0.07556 mg/L PBTK NA 95% Rat Human +DTXSID5046067 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046067 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046067 Vd NA 0.7925 L/kg 1compartment NA NA Human Human +DTXSID5046067 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5046067 TK.Half.Life NA 15.42 hours 1compartment NA NA Human Human +DTXSID5046067 Css NA 2.098 mg/L 3compartmentss NA 50% Human Human +DTXSID5046067 Css NA 8.343 mg/L 3compartmentss NA 95% Human Human +DTXSID5046067 Css NA 1.544 mg/L PBTK NA 50% Human Human +DTXSID5046067 Css NA 5.385 mg/L PBTK NA 95% Human Human +DTXSID5046067 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046067 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046067 Vd NA 0.7018 L/kg 1compartment NA NA Rat Human DTXSID5046067 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046067 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human -DTXSID5046067 Css NA 0.3286 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046067 Css NA 1.211 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046067 Css NA 0.2193 mg/L PBTK NA 50% Rat Human -DTXSID5046067 Css NA 0.712 mg/L PBTK NA 95% Rat Human -DTXSID5046069 Clint NA 39.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046069 Fup NA 0.0364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046069 Vd NA 2.56 L/kg 1compartment NA NA Human Human -DTXSID5046069 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046069 TK.Half.Life NA 13.96 hours 1compartment NA NA Human Human -DTXSID5046069 Css NA 0.7004 mg/L 3compartmentss NA 50% Human Human -DTXSID5046069 Css NA 4.694 mg/L 3compartmentss NA 95% Human Human -DTXSID5046069 Css NA 0.4684 mg/L PBTK NA 50% Human Human -DTXSID5046069 Css NA 2.99 mg/L PBTK NA 95% Human Human -DTXSID5046069 Clint NA 39.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046069 Fup NA 0.0364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046069 Vd NA 1.915 L/kg 1compartment NA NA Rat Human -DTXSID5046069 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046069 TK.Half.Life NA 3.462 hours 1compartment NA NA Rat Human -DTXSID5046069 Css NA 0.3913 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046069 Css NA 2.137 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046069 Css NA 0.2494 mg/L PBTK NA 50% Rat Human -DTXSID5046069 Css NA 1.326 mg/L PBTK NA 95% Rat Human -DTXSID5046142 Clint NA 6.907 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046142 Fup NA 0.128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046142 Vd NA 1.884 L/kg 1compartment NA NA Human Human +DTXSID5046067 TK.Half.Life NA 4.495 hours 1compartment NA NA Rat Human +DTXSID5046067 Css NA 0.1339 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046067 Css NA 0.4769 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046067 Css NA 0.09734 mg/L PBTK NA 50% Rat Human +DTXSID5046067 Css NA 0.2928 mg/L PBTK NA 95% Rat Human +DTXSID5046069 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046069 Fup 0.0102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046069 Vd NA 1.944 L/kg 1compartment NA NA Human Human +DTXSID5046069 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5046069 TK.Half.Life NA 29.84 hours 1compartment NA NA Human Human +DTXSID5046069 Css NA 2.351 mg/L 3compartmentss NA 50% Human Human +DTXSID5046069 Css NA 20.22 mg/L 3compartmentss NA 95% Human Human +DTXSID5046069 Css NA 1.501 mg/L PBTK NA 50% Human Human +DTXSID5046069 Css NA 12.38 mg/L PBTK NA 95% Human Human +DTXSID5046069 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046069 Fup 0.0102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046069 Vd NA 1.439 L/kg 1compartment NA NA Rat Human +DTXSID5046069 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5046069 TK.Half.Life NA 9.789 hours 1compartment NA NA Rat Human +DTXSID5046069 Css NA 0.3074 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046069 Css NA 2.17 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046069 Css NA 0.1912 mg/L PBTK NA 50% Rat Human +DTXSID5046069 Css NA 1.292 mg/L PBTK NA 95% Rat Human +DTXSID5046140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046140 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046140 Vd NA 2.471 L/kg 1compartment NA NA Human Human +DTXSID5046140 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5046140 TK.Half.Life NA 30.08 hours 1compartment NA NA Human Human +DTXSID5046140 Css NA 1.707 mg/L 3compartmentss NA 50% Human Human +DTXSID5046140 Css NA 12.35 mg/L 3compartmentss NA 95% Human Human +DTXSID5046140 Css NA 1.127 mg/L PBTK NA 50% Human Human +DTXSID5046140 Css NA 7.861 mg/L PBTK NA 95% Human Human +DTXSID5046140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046140 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046140 Vd NA 1.845 L/kg 1compartment NA NA Rat Human +DTXSID5046140 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5046140 TK.Half.Life NA 7.603 hours 1compartment NA NA Rat Human +DTXSID5046140 Css NA 0.2181 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046140 Css NA 1.372 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046140 Css NA 0.1414 mg/L PBTK NA 50% Rat Human +DTXSID5046140 Css NA 0.8595 mg/L PBTK NA 95% Rat Human +DTXSID5046142 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046142 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046142 Vd NA 2.935 L/kg 1compartment NA NA Human Human DTXSID5046142 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046142 TK.Half.Life NA 10.06 hours 1compartment NA NA Human Human -DTXSID5046142 Css NA 0.6531 mg/L 3compartmentss NA 50% Human Human -DTXSID5046142 Css NA 4.561 mg/L 3compartmentss NA 95% Human Human -DTXSID5046142 Css NA 0.476 mg/L PBTK NA 50% Human Human -DTXSID5046142 Css NA 2.992 mg/L PBTK NA 95% Human Human -DTXSID5046142 Clint NA 6.907 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046142 Fup NA 0.128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046142 Vd NA 1.607 L/kg 1compartment NA NA Rat Human +DTXSID5046142 TK.Half.Life NA 4.035 hours 1compartment NA NA Human Human +DTXSID5046142 Css NA 0.07568 mg/L 3compartmentss NA 50% Human Human +DTXSID5046142 Css NA 0.5325 mg/L 3compartmentss NA 95% Human Human +DTXSID5046142 Css NA 0.06762 mg/L PBTK NA 50% Human Human +DTXSID5046142 Css NA 0.4241 mg/L PBTK NA 95% Human Human +DTXSID5046142 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046142 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046142 Vd NA 2.546 L/kg 1compartment NA NA Rat Human DTXSID5046142 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046142 TK.Half.Life NA 4.435 hours 1compartment NA NA Rat Human -DTXSID5046142 Css NA 0.3394 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046142 Css NA 1.691 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046142 Css NA 0.2357 mg/L PBTK NA 50% Rat Human -DTXSID5046142 Css NA 1.05 mg/L PBTK NA 95% Rat Human -DTXSID5046144 Clint NA 51.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046144 Fup NA 0.6785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046144 Vd NA 4.608 L/kg 1compartment NA NA Human Human +DTXSID5046142 TK.Half.Life NA 1.511 hours 1compartment NA NA Rat Human +DTXSID5046142 Css NA 0.009331 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046142 Css NA 0.05143 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046142 Css NA 0.00845 mg/L PBTK NA 50% Rat Human +DTXSID5046142 Css NA 0.0415 mg/L PBTK NA 95% Rat Human +DTXSID5046144 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046144 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046144 Vd NA 3.927 L/kg 1compartment NA NA Human Human DTXSID5046144 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046144 TK.Half.Life NA 1.99 hours 1compartment NA NA Human Human -DTXSID5046144 Css NA 0.007508 mg/L 3compartmentss NA 50% Human Human -DTXSID5046144 Css NA 0.1064 mg/L 3compartmentss NA 95% Human Human -DTXSID5046144 Css NA 0.01085 mg/L PBTK NA 50% Human Human -DTXSID5046144 Css NA 0.1018 mg/L PBTK NA 95% Human Human -DTXSID5046144 Clint NA 51.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046144 Fup NA 0.6785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046144 Vd NA 4.715 L/kg 1compartment NA NA Rat Human +DTXSID5046144 TK.Half.Life NA 5.617 hours 1compartment NA NA Human Human +DTXSID5046144 Css NA 0.07501 mg/L 3compartmentss NA 50% Human Human +DTXSID5046144 Css NA 0.6891 mg/L 3compartmentss NA 95% Human Human +DTXSID5046144 Css NA 0.0975 mg/L PBTK NA 50% Human Human +DTXSID5046144 Css NA 0.6303 mg/L PBTK NA 95% Human Human +DTXSID5046144 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046144 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046144 Vd NA 4.002 L/kg 1compartment NA NA Rat Human DTXSID5046144 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046144 TK.Half.Life NA 0.993 hours 1compartment NA NA Rat Human -DTXSID5046144 Css NA 0.00373 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046144 Css NA 0.05194 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046144 Css NA 0.005548 mg/L PBTK NA 50% Rat Human -DTXSID5046144 Css NA 0.0449 mg/L PBTK NA 95% Rat Human -DTXSID5046148 Clint NA 70.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046148 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046148 Vd NA 1.51 L/kg 1compartment NA NA Human Human +DTXSID5046144 TK.Half.Life NA 3.299 hours 1compartment NA NA Rat Human +DTXSID5046144 Css NA 0.008014 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046144 Css NA 0.06569 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046144 Css NA 0.0112 mg/L PBTK NA 50% Rat Human +DTXSID5046144 Css NA 0.05578 mg/L PBTK NA 95% Rat Human +DTXSID5046148 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046148 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046148 Vd NA 1.133 L/kg 1compartment NA NA Human Human DTXSID5046148 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046148 TK.Half.Life NA 3.685 hours 1compartment NA NA Human Human -DTXSID5046148 Css NA 0.2769 mg/L 3compartmentss NA 50% Human Human -DTXSID5046148 Css NA 2.082 mg/L 3compartmentss NA 95% Human Human -DTXSID5046148 Css NA 0.1758 mg/L PBTK NA 50% Human Human -DTXSID5046148 Css NA 1.28 mg/L PBTK NA 95% Human Human -DTXSID5046148 Clint NA 70.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046148 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046148 Vd NA 1.136 L/kg 1compartment NA NA Rat Human +DTXSID5046148 TK.Half.Life NA 6.472 hours 1compartment NA NA Human Human +DTXSID5046148 Css NA 0.739 mg/L 3compartmentss NA 50% Human Human +DTXSID5046148 Css NA 4.973 mg/L 3compartmentss NA 95% Human Human +DTXSID5046148 Css NA 0.4926 mg/L PBTK NA 50% Human Human +DTXSID5046148 Css NA 3.103 mg/L PBTK NA 95% Human Human +DTXSID5046148 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046148 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046148 Vd NA 0.9072 L/kg 1compartment NA NA Rat Human DTXSID5046148 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046148 TK.Half.Life NA 1.392 hours 1compartment NA NA Rat Human -DTXSID5046148 Css NA 0.1583 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046148 Css NA 1.009 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046148 Css NA 0.09396 mg/L PBTK NA 50% Rat Human -DTXSID5046148 Css NA 0.5819 mg/L PBTK NA 95% Rat Human -DTXSID5046190 Clint NA 2.276 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046190 Fup NA 0.2461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046190 Vd NA 0.9704 L/kg 1compartment NA NA Human Human +DTXSID5046148 TK.Half.Life NA 2.86 hours 1compartment NA NA Rat Human +DTXSID5046148 Css NA 0.08972 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046148 Css NA 0.4596 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046148 Css NA 0.05874 mg/L PBTK NA 50% Rat Human +DTXSID5046148 Css NA 0.2726 mg/L PBTK NA 95% Rat Human +DTXSID5046190 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046190 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046190 Vd NA 1.076 L/kg 1compartment NA NA Human Human DTXSID5046190 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046190 TK.Half.Life NA 6.091 hours 1compartment NA NA Human Human -DTXSID5046190 Css NA 0.6826 mg/L 3compartmentss NA 50% Human Human -DTXSID5046190 Css NA 3.425 mg/L 3compartmentss NA 95% Human Human -DTXSID5046190 Css NA 0.496 mg/L PBTK NA 50% Human Human -DTXSID5046190 Css NA 2.215 mg/L PBTK NA 95% Human Human -DTXSID5046190 Clint NA 2.276 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046190 Fup NA 0.2461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046190 Vd NA 0.8208 L/kg 1compartment NA NA Rat Human +DTXSID5046190 TK.Half.Life NA 3.391 hours 1compartment NA NA Human Human +DTXSID5046190 Css NA 0.2892 mg/L 3compartmentss NA 50% Human Human +DTXSID5046190 Css NA 1.77 mg/L 3compartmentss NA 95% Human Human +DTXSID5046190 Css NA 0.209 mg/L PBTK NA 50% Human Human +DTXSID5046190 Css NA 1.182 mg/L PBTK NA 95% Human Human +DTXSID5046190 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046190 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046190 Vd NA 0.8944 L/kg 1compartment NA NA Rat Human DTXSID5046190 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046190 TK.Half.Life NA 2.693 hours 1compartment NA NA Rat Human -DTXSID5046190 Css NA 0.3179 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046190 Css NA 1.17 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046190 Css NA 0.2194 mg/L PBTK NA 50% Rat Human -DTXSID5046190 Css NA 0.7122 mg/L PBTK NA 95% Rat Human -DTXSID5046192 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046192 Fup NA 0.0681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046192 Vd NA 2.061 L/kg 1compartment NA NA Human Human -DTXSID5046192 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5046192 TK.Half.Life NA 30.15 hours 1compartment NA NA Human Human -DTXSID5046192 Css NA 2.09 mg/L 3compartmentss NA 50% Human Human -DTXSID5046192 Css NA 11.98 mg/L 3compartmentss NA 95% Human Human -DTXSID5046192 Css NA 1.403 mg/L PBTK NA 50% Human Human -DTXSID5046192 Css NA 7.649 mg/L PBTK NA 95% Human Human -DTXSID5046192 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046192 Fup NA 0.0681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046192 Vd NA 1.59 L/kg 1compartment NA NA Rat Human -DTXSID5046192 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5046192 TK.Half.Life NA 9.832 hours 1compartment NA NA Rat Human -DTXSID5046192 Css NA 1.097 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046192 Css NA 4.533 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046192 Css NA 0.7018 mg/L PBTK NA 50% Rat Human -DTXSID5046192 Css NA 2.71 mg/L PBTK NA 95% Rat Human -DTXSID5046196 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046196 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046196 Vd NA 0.8737 L/kg 1compartment NA NA Human Human +DTXSID5046190 TK.Half.Life NA 1.537 hours 1compartment NA NA Rat Human +DTXSID5046190 Css NA 0.03465 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046190 Css NA 0.1494 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046190 Css NA 0.02493 mg/L PBTK NA 50% Rat Human +DTXSID5046190 Css NA 0.09528 mg/L PBTK NA 95% Rat Human +DTXSID5046192 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046192 Fup 0.0877 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046192 Vd NA 2.085 L/kg 1compartment NA NA Human Human +DTXSID5046192 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046192 TK.Half.Life NA 7.374 hours 1compartment NA NA Human Human +DTXSID5046192 Css NA 0.3938 mg/L 3compartmentss NA 50% Human Human +DTXSID5046192 Css NA 2.78 mg/L 3compartmentss NA 95% Human Human +DTXSID5046192 Css NA 0.2695 mg/L PBTK NA 50% Human Human +DTXSID5046192 Css NA 1.814 mg/L PBTK NA 95% Human Human +DTXSID5046192 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046192 Fup 0.0877 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046192 Vd NA 1.622 L/kg 1compartment NA NA Rat Human +DTXSID5046192 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5046192 TK.Half.Life NA 2.562 hours 1compartment NA NA Rat Human +DTXSID5046192 Css NA 0.05098 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046192 Css NA 0.2923 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046192 Css NA 0.03429 mg/L PBTK NA 50% Rat Human +DTXSID5046192 Css NA 0.1885 mg/L PBTK NA 95% Rat Human +DTXSID5046194 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046194 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046194 Vd NA 2.892 L/kg 1compartment NA NA Human Human +DTXSID5046194 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046194 TK.Half.Life NA 2.523 hours 1compartment NA NA Human Human +DTXSID5046194 Css NA 0.03288 mg/L 3compartmentss NA 50% Human Human +DTXSID5046194 Css NA 0.3255 mg/L 3compartmentss NA 95% Human Human +DTXSID5046194 Css NA 0.03409 mg/L PBTK NA 50% Human Human +DTXSID5046194 Css NA 0.2668 mg/L PBTK NA 95% Human Human +DTXSID5046194 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046194 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046194 Vd NA 2.731 L/kg 1compartment NA NA Rat Human +DTXSID5046194 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5046194 TK.Half.Life NA 1.154 hours 1compartment NA NA Rat Human +DTXSID5046194 Css NA 0.004006 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046194 Css NA 0.0328 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046194 Css NA 0.004269 mg/L PBTK NA 50% Rat Human +DTXSID5046194 Css NA 0.0261 mg/L PBTK NA 95% Rat Human +DTXSID5046196 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046196 Fup 0.873 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046196 Vd NA 0.9215 L/kg 1compartment NA NA Human Human DTXSID5046196 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046196 TK.Half.Life NA 5.654 hours 1compartment NA NA Human Human -DTXSID5046196 Css NA 0.8169 mg/L 3compartmentss NA 50% Human Human -DTXSID5046196 Css NA 5.537 mg/L 3compartmentss NA 95% Human Human -DTXSID5046196 Css NA 0.6988 mg/L PBTK NA 50% Human Human -DTXSID5046196 Css NA 3.648 mg/L PBTK NA 95% Human Human -DTXSID5046196 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046196 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046196 Vd NA 0.9095 L/kg 1compartment NA NA Rat Human +DTXSID5046196 TK.Half.Life NA 6.849 hours 1compartment NA NA Human Human +DTXSID5046196 Css NA 0.8778 mg/L 3compartmentss NA 50% Human Human +DTXSID5046196 Css NA 5.04 mg/L 3compartmentss NA 95% Human Human +DTXSID5046196 Css NA 0.7534 mg/L PBTK NA 50% Human Human +DTXSID5046196 Css NA 3.32 mg/L PBTK NA 95% Human Human +DTXSID5046196 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046196 Fup 0.873 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046196 Vd NA 0.9416 L/kg 1compartment NA NA Rat Human DTXSID5046196 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046196 TK.Half.Life NA 2.006 hours 1compartment NA NA Rat Human -DTXSID5046196 Css NA 0.2048 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046196 Css NA 1.323 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046196 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID5046196 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5046198 Clint NA 384.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046198 Fup NA 0.0074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046198 Vd NA 224.5 L/kg 1compartment NA NA Human Human -DTXSID5046198 Days.Css NA 78 Days PBTK NA NA Human Human -DTXSID5046198 TK.Half.Life NA 380.2 hours 1compartment NA NA Human Human -DTXSID5046198 Css NA 0.004608 mg/L 3compartmentss NA 50% Human Human -DTXSID5046198 Css NA 0.02715 mg/L 3compartmentss NA 95% Human Human -DTXSID5046198 Css NA 0.139 mg/L PBTK NA 50% Human Human -DTXSID5046198 Css NA 0.7561 mg/L PBTK NA 95% Human Human -DTXSID5046198 Clint NA 384.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046198 Fup NA 0.0074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046198 Vd NA 198.8 L/kg 1compartment NA NA Rat Human -DTXSID5046198 Days.Css NA 56 Days PBTK NA NA Rat Human -DTXSID5046198 TK.Half.Life NA 60.54 hours 1compartment NA NA Rat Human -DTXSID5046198 Css NA 0.00234 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046198 Css NA 0.0105 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046198 Css NA 0.07554 mg/L PBTK NA 50% Rat Human -DTXSID5046198 Css NA 0.3346 mg/L PBTK NA 95% Rat Human -DTXSID5046221 Clint NA 554.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046221 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046221 Vd NA 1.562 L/kg 1compartment NA NA Human Human +DTXSID5046196 TK.Half.Life NA 2.379 hours 1compartment NA NA Rat Human +DTXSID5046196 Css NA 0.0528 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046196 Css NA 0.3076 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046196 Css NA 0.04538 mg/L PBTK NA 50% Rat Human +DTXSID5046196 Css NA 0.1936 mg/L PBTK NA 95% Rat Human +DTXSID5046198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046198 Fup 0.025 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046198 Vd NA 11.69 L/kg 1compartment NA NA Human Human +DTXSID5046198 Days.Css NA 74 Days PBTK NA NA Human Human +DTXSID5046198 TK.Half.Life NA 347.4 hours 1compartment NA NA Human Human +DTXSID5046198 Css NA 1.753 mg/L 3compartmentss NA 50% Human Human +DTXSID5046198 Css NA 11.05 mg/L 3compartmentss NA 95% Human Human +DTXSID5046198 Css NA 2.342 mg/L PBTK NA 50% Human Human +DTXSID5046198 Css NA 13.94 mg/L PBTK NA 95% Human Human +DTXSID5046198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046198 Fup 0.025 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046198 Vd NA 9.264 L/kg 1compartment NA NA Rat Human +DTXSID5046198 Days.Css NA 44 Days PBTK NA NA Rat Human +DTXSID5046198 TK.Half.Life NA 47.84 hours 1compartment NA NA Rat Human +DTXSID5046198 Css NA 0.221 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046198 Css NA 1.022 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046198 Css NA 0.3074 mg/L PBTK NA 50% Rat Human +DTXSID5046198 Css NA 1.44 mg/L PBTK NA 95% Rat Human +DTXSID5046221 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046221 Fup 0.0527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046221 Vd NA 1.992 L/kg 1compartment NA NA Human Human DTXSID5046221 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046221 TK.Half.Life NA 2.067 hours 1compartment NA NA Human Human -DTXSID5046221 Css NA 0.07306 mg/L 3compartmentss NA 50% Human Human -DTXSID5046221 Css NA 0.6903 mg/L 3compartmentss NA 95% Human Human -DTXSID5046221 Css NA 0.04572 mg/L PBTK NA 50% Human Human -DTXSID5046221 Css NA 0.4124 mg/L PBTK NA 95% Human Human -DTXSID5046221 Clint NA 554.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046221 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046221 Vd NA 1.155 L/kg 1compartment NA NA Rat Human +DTXSID5046221 TK.Half.Life NA 10.39 hours 1compartment NA NA Human Human +DTXSID5046221 Css NA 0.6684 mg/L 3compartmentss NA 50% Human Human +DTXSID5046221 Css NA 4.831 mg/L 3compartmentss NA 95% Human Human +DTXSID5046221 Css NA 0.4394 mg/L PBTK NA 50% Human Human +DTXSID5046221 Css NA 3.024 mg/L PBTK NA 95% Human Human +DTXSID5046221 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046221 Fup 0.0527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046221 Vd NA 1.493 L/kg 1compartment NA NA Rat Human DTXSID5046221 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046221 TK.Half.Life NA 0.7122 hours 1compartment NA NA Rat Human -DTXSID5046221 Css NA 0.04228 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046221 Css NA 0.3253 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046221 Css NA 0.02475 mg/L PBTK NA 50% Rat Human -DTXSID5046221 Css NA 0.181 mg/L PBTK NA 95% Rat Human -DTXSID5046223 Clint NA 34.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046223 Fup NA 0.0655 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046223 Vd NA 1.295 L/kg 1compartment NA NA Human Human -DTXSID5046223 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046223 TK.Half.Life NA 3.473 hours 1compartment NA NA Human Human -DTXSID5046223 Css NA 0.2934 mg/L 3compartmentss NA 50% Human Human -DTXSID5046223 Css NA 2.097 mg/L 3compartmentss NA 95% Human Human -DTXSID5046223 Css NA 0.1886 mg/L PBTK NA 50% Human Human -DTXSID5046223 Css NA 1.317 mg/L PBTK NA 95% Human Human -DTXSID5046223 Clint NA 34.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046223 Fup NA 0.0655 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046223 Vd NA 0.9854 L/kg 1compartment NA NA Rat Human +DTXSID5046221 TK.Half.Life NA 3.401 hours 1compartment NA NA Rat Human +DTXSID5046221 Css NA 0.08704 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046221 Css NA 0.5185 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046221 Css NA 0.05622 mg/L PBTK NA 50% Rat Human +DTXSID5046221 Css NA 0.316 mg/L PBTK NA 95% Rat Human +DTXSID5046223 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046223 Fup 0.0994 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046223 Vd NA 1.694 L/kg 1compartment NA NA Human Human +DTXSID5046223 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5046223 TK.Half.Life NA 13.49 hours 1compartment NA NA Human Human +DTXSID5046223 Css NA 1.074 mg/L 3compartmentss NA 50% Human Human +DTXSID5046223 Css NA 6.667 mg/L 3compartmentss NA 95% Human Human +DTXSID5046223 Css NA 0.7138 mg/L PBTK NA 50% Human Human +DTXSID5046223 Css NA 4.193 mg/L PBTK NA 95% Human Human +DTXSID5046223 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046223 Fup 0.0994 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046223 Vd NA 1.291 L/kg 1compartment NA NA Rat Human DTXSID5046223 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046223 TK.Half.Life NA 1.395 hours 1compartment NA NA Rat Human -DTXSID5046223 Css NA 0.1648 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046223 Css NA 0.9181 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046223 Css NA 0.1001 mg/L PBTK NA 50% Rat Human -DTXSID5046223 Css NA 0.5424 mg/L PBTK NA 95% Rat Human -DTXSID5046225 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046225 Fup NA 0.0039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046225 Vd NA 0.1954 L/kg 1compartment NA NA Human Human -DTXSID5046225 Days.Css NA 81 Days PBTK NA NA Human Human -DTXSID5046225 TK.Half.Life NA 324.5 hours 1compartment NA NA Human Human -DTXSID5046225 Css NA 310.5 mg/L 3compartmentss NA 50% Human Human -DTXSID5046225 Css NA 1327 mg/L 3compartmentss NA 95% Human Human -DTXSID5046225 Css NA 179.9 mg/L PBTK NA 50% Human Human -DTXSID5046225 Css NA 771 mg/L PBTK NA 95% Human Human -DTXSID5046225 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046225 Fup NA 0.0039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046225 Vd NA 0.1822 L/kg 1compartment NA NA Rat Human -DTXSID5046225 Days.Css NA 22 Days PBTK NA NA Rat Human -DTXSID5046225 TK.Half.Life NA 103 hours 1compartment NA NA Rat Human -DTXSID5046225 Css NA 87.48 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046225 Css NA 323.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046225 Css NA 47.5 mg/L PBTK NA 50% Rat Human -DTXSID5046225 Css NA 174.8 mg/L PBTK NA 95% Rat Human +DTXSID5046223 TK.Half.Life NA 4.847 hours 1compartment NA NA Rat Human +DTXSID5046223 Css NA 0.1312 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046223 Css NA 0.6027 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046223 Css NA 0.08558 mg/L PBTK NA 50% Rat Human +DTXSID5046223 Css NA 0.3721 mg/L PBTK NA 95% Rat Human +DTXSID5046225 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046225 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046225 Vd NA 0.2399 L/kg 1compartment NA NA Human Human +DTXSID5046225 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046225 TK.Half.Life NA 3.546 hours 1compartment NA NA Human Human +DTXSID5046225 Css NA 2.607 mg/L 3compartmentss NA 50% Human Human +DTXSID5046225 Css NA 25.34 mg/L 3compartmentss NA 95% Human Human +DTXSID5046225 Css NA 1.525 mg/L PBTK NA 50% Human Human +DTXSID5046225 Css NA 14.94 mg/L PBTK NA 95% Human Human +DTXSID5046225 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046225 Fup 0.0122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046225 Vd NA 0.2178 L/kg 1compartment NA NA Rat Human +DTXSID5046225 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5046225 TK.Half.Life NA 2.141 hours 1compartment NA NA Rat Human +DTXSID5046225 Css NA 0.3396 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046225 Css NA 2.57 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046225 Css NA 0.1937 mg/L PBTK NA 50% Rat Human +DTXSID5046225 Css NA 1.449 mg/L PBTK NA 95% Rat Human DTXSID5046227 Clint NA 85.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5046227 Fup NA 0.0018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046227 Vd NA 1.136 L/kg 1compartment NA NA Human Human -DTXSID5046227 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5046227 TK.Half.Life NA 14.1 hours 1compartment NA NA Human Human -DTXSID5046227 Css NA 2.109 mg/L 3compartmentss NA 50% Human Human -DTXSID5046227 Css NA 19.9 mg/L 3compartmentss NA 95% Human Human -DTXSID5046227 Css NA 1.273 mg/L PBTK NA 50% Human Human -DTXSID5046227 Css NA 11.77 mg/L PBTK NA 95% Human Human +DTXSID5046227 Vd NA 0.17 L/kg 1compartment NA NA Human Human +DTXSID5046227 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046227 TK.Half.Life NA 4.311 hours 1compartment NA NA Human Human +DTXSID5046227 Css NA 4.63 mg/L 3compartmentss NA 50% Human Human +DTXSID5046227 Css NA 46.51 mg/L 3compartmentss NA 95% Human Human +DTXSID5046227 Css NA 2.71 mg/L PBTK NA 50% Human Human +DTXSID5046227 Css NA 27.34 mg/L PBTK NA 95% Human Human DTXSID5046227 Clint NA 85.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5046227 Fup NA 0.0018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046227 Vd NA 0.8292 L/kg 1compartment NA NA Rat Human +DTXSID5046227 Vd NA 0.1645 L/kg 1compartment NA NA Rat Human DTXSID5046227 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046227 TK.Half.Life NA 5.996 hours 1compartment NA NA Rat Human -DTXSID5046227 Css NA 1.22 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046227 Css NA 9.213 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046227 Css NA 0.6877 mg/L PBTK NA 50% Rat Human -DTXSID5046227 Css NA 5.043 mg/L PBTK NA 95% Rat Human -DTXSID5046229 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046229 Fup NA 0.108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046229 Vd NA 2.306 L/kg 1compartment NA NA Human Human -DTXSID5046229 Days.Css NA 76 Days PBTK NA NA Human Human -DTXSID5046229 TK.Half.Life NA 336.2 hours 1compartment NA NA Human Human -DTXSID5046229 Css NA 19.01 mg/L 3compartmentss NA 50% Human Human -DTXSID5046229 Css NA 64.48 mg/L 3compartmentss NA 95% Human Human -DTXSID5046229 Css NA 13.07 mg/L PBTK NA 50% Human Human -DTXSID5046229 Css NA 40.53 mg/L PBTK NA 95% Human Human -DTXSID5046229 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046229 Fup NA 0.108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046229 Vd NA 1.743 L/kg 1compartment NA NA Rat Human -DTXSID5046229 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID5046229 TK.Half.Life NA 47.74 hours 1compartment NA NA Rat Human -DTXSID5046229 Css NA 5.189 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046229 Css NA 14.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046229 Css NA 3.394 mg/L PBTK NA 50% Rat Human -DTXSID5046229 Css NA 8.591 mg/L PBTK NA 95% Rat Human -DTXSID5046271 Clint NA 10.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046271 Fup NA 0.2924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046271 Vd NA 2.551 L/kg 1compartment NA NA Human Human +DTXSID5046227 TK.Half.Life NA 2.864 hours 1compartment NA NA Rat Human +DTXSID5046227 Css NA 0.621 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046227 Css NA 5.258 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046227 Css NA 0.3478 mg/L PBTK NA 50% Rat Human +DTXSID5046227 Css NA 2.941 mg/L PBTK NA 95% Rat Human +DTXSID5046229 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046229 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046229 Vd NA 2.043 L/kg 1compartment NA NA Human Human +DTXSID5046229 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046229 TK.Half.Life NA 8.714 hours 1compartment NA NA Human Human +DTXSID5046229 Css NA 0.514 mg/L 3compartmentss NA 50% Human Human +DTXSID5046229 Css NA 3.394 mg/L 3compartmentss NA 95% Human Human +DTXSID5046229 Css NA 0.3419 mg/L PBTK NA 50% Human Human +DTXSID5046229 Css NA 2.144 mg/L PBTK NA 95% Human Human +DTXSID5046229 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046229 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046229 Vd NA 1.538 L/kg 1compartment NA NA Rat Human +DTXSID5046229 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5046229 TK.Half.Life NA 2.818 hours 1compartment NA NA Rat Human +DTXSID5046229 Css NA 0.06592 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046229 Css NA 0.3558 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046229 Css NA 0.04298 mg/L PBTK NA 50% Rat Human +DTXSID5046229 Css NA 0.2246 mg/L PBTK NA 95% Rat Human +DTXSID5046271 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046271 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046271 Vd NA 2.56 L/kg 1compartment NA NA Human Human DTXSID5046271 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046271 TK.Half.Life NA 4.198 hours 1compartment NA NA Human Human -DTXSID5046271 Css NA 0.1028 mg/L 3compartmentss NA 50% Human Human -DTXSID5046271 Css NA 0.7718 mg/L 3compartmentss NA 95% Human Human -DTXSID5046271 Css NA 0.1018 mg/L PBTK NA 50% Human Human -DTXSID5046271 Css NA 0.6268 mg/L PBTK NA 95% Human Human -DTXSID5046271 Clint NA 10.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046271 Fup NA 0.2924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046271 Vd NA 2.567 L/kg 1compartment NA NA Rat Human +DTXSID5046271 TK.Half.Life NA 4.289 hours 1compartment NA NA Human Human +DTXSID5046271 Css NA 0.1036 mg/L 3compartmentss NA 50% Human Human +DTXSID5046271 Css NA 0.8301 mg/L 3compartmentss NA 95% Human Human +DTXSID5046271 Css NA 0.1084 mg/L PBTK NA 50% Human Human +DTXSID5046271 Css NA 0.6694 mg/L PBTK NA 95% Human Human +DTXSID5046271 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046271 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046271 Vd NA 2.592 L/kg 1compartment NA NA Rat Human DTXSID5046271 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046271 TK.Half.Life NA 2.435 hours 1compartment NA NA Rat Human -DTXSID5046271 Css NA 0.05354 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046271 Css NA 0.3033 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046271 Css NA 0.052 mg/L PBTK NA 50% Rat Human -DTXSID5046271 Css NA 0.2354 mg/L PBTK NA 95% Rat Human -DTXSID5046273 Clint NA 6.019 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046273 Fup NA 0.0452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046273 Vd NA 0.3302 L/kg 1compartment NA NA Human Human +DTXSID5046271 TK.Half.Life NA 2.481 hours 1compartment NA NA Rat Human +DTXSID5046271 Css NA 0.01171 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046271 Css NA 0.07429 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046271 Css NA 0.01254 mg/L PBTK NA 50% Rat Human +DTXSID5046271 Css NA 0.0569 mg/L PBTK NA 95% Rat Human +DTXSID5046273 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046273 Fup 0.0876 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046273 Vd NA 0.4397 L/kg 1compartment NA NA Human Human DTXSID5046273 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046273 TK.Half.Life NA 4.475 hours 1compartment NA NA Human Human -DTXSID5046273 Css NA 2.322 mg/L 3compartmentss NA 50% Human Human -DTXSID5046273 Css NA 15.35 mg/L 3compartmentss NA 95% Human Human -DTXSID5046273 Css NA 1.407 mg/L PBTK NA 50% Human Human -DTXSID5046273 Css NA 8.893 mg/L PBTK NA 95% Human Human -DTXSID5046273 Clint NA 6.019 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046273 Fup NA 0.0452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046273 Vd NA 0.2905 L/kg 1compartment NA NA Rat Human +DTXSID5046273 TK.Half.Life NA 1.238 hours 1compartment NA NA Human Human +DTXSID5046273 Css NA 0.3246 mg/L 3compartmentss NA 50% Human Human +DTXSID5046273 Css NA 2.565 mg/L 3compartmentss NA 95% Human Human +DTXSID5046273 Css NA 0.2032 mg/L PBTK NA 50% Human Human +DTXSID5046273 Css NA 1.527 mg/L PBTK NA 95% Human Human +DTXSID5046273 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046273 Fup 0.0876 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046273 Vd NA 0.3833 L/kg 1compartment NA NA Rat Human DTXSID5046273 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046273 TK.Half.Life NA 2.448 hours 1compartment NA NA Rat Human -DTXSID5046273 Css NA 1.234 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046273 Css NA 5.972 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046273 Css NA 0.6931 mg/L PBTK NA 50% Rat Human -DTXSID5046273 Css NA 3.284 mg/L PBTK NA 95% Rat Human -DTXSID5046275 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046275 Fup NA 0.3191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046275 Vd NA 0.3199 L/kg 1compartment NA NA Human Human +DTXSID5046273 TK.Half.Life NA 0.6436 hours 1compartment NA NA Rat Human +DTXSID5046273 Css NA 0.04248 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046273 Css NA 0.2667 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046273 Css NA 0.02586 mg/L PBTK NA 50% Rat Human +DTXSID5046273 Css NA 0.1558 mg/L PBTK NA 95% Rat Human +DTXSID5046275 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046275 Fup 0.443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046275 Vd NA 0.3701 L/kg 1compartment NA NA Human Human DTXSID5046275 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046275 TK.Half.Life NA 6.484 hours 1compartment NA NA Human Human -DTXSID5046275 Css NA 2.533 mg/L 3compartmentss NA 50% Human Human -DTXSID5046275 Css NA 9.861 mg/L 3compartmentss NA 95% Human Human -DTXSID5046275 Css NA 1.664 mg/L PBTK NA 50% Human Human -DTXSID5046275 Css NA 5.974 mg/L PBTK NA 95% Human Human -DTXSID5046275 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046275 Fup NA 0.3191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046275 Vd NA 0.3272 L/kg 1compartment NA NA Rat Human +DTXSID5046275 TK.Half.Life NA 5.407 hours 1compartment NA NA Human Human +DTXSID5046275 Css NA 0.941 mg/L 3compartmentss NA 50% Human Human +DTXSID5046275 Css NA 4.489 mg/L 3compartmentss NA 95% Human Human +DTXSID5046275 Css NA 0.6544 mg/L PBTK NA 50% Human Human +DTXSID5046275 Css NA 2.775 mg/L PBTK NA 95% Human Human +DTXSID5046275 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046275 Fup 0.443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046275 Vd NA 0.3799 L/kg 1compartment NA NA Rat Human DTXSID5046275 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046275 TK.Half.Life NA 2.261 hours 1compartment NA NA Rat Human -DTXSID5046275 Css NA 0.7019 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046275 Css NA 2.272 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046275 Css NA 0.4373 mg/L PBTK NA 50% Rat Human -DTXSID5046275 Css NA 1.291 mg/L PBTK NA 95% Rat Human -DTXSID5046277 Clint NA 0.1177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046277 Fup NA 0.0673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046277 Vd NA 0.2968 L/kg 1compartment NA NA Human Human -DTXSID5046277 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5046277 TK.Half.Life NA 23.93 hours 1compartment NA NA Human Human -DTXSID5046277 Css NA 12.72 mg/L 3compartmentss NA 50% Human Human -DTXSID5046277 Css NA 51.03 mg/L 3compartmentss NA 95% Human Human -DTXSID5046277 Css NA 7.657 mg/L PBTK NA 50% Human Human -DTXSID5046277 Css NA 29.93 mg/L PBTK NA 95% Human Human -DTXSID5046277 Clint NA 0.1177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046277 Fup NA 0.0673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046277 Vd NA 0.2727 L/kg 1compartment NA NA Rat Human +DTXSID5046275 TK.Half.Life NA 1.89 hours 1compartment NA NA Rat Human +DTXSID5046275 Css NA 0.005156 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046275 Css NA 0.02451 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046275 Css NA 0.003392 mg/L PBTK NA 50% Rat Human +DTXSID5046275 Css NA 0.0146 mg/L PBTK NA 95% Rat Human +DTXSID5046277 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046277 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046277 Vd NA 0.5689 L/kg 1compartment NA NA Human Human +DTXSID5046277 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046277 TK.Half.Life NA 2.962 hours 1compartment NA NA Human Human +DTXSID5046277 Css NA 0.6896 mg/L 3compartmentss NA 50% Human Human +DTXSID5046277 Css NA 4.905 mg/L 3compartmentss NA 95% Human Human +DTXSID5046277 Css NA 0.4379 mg/L PBTK NA 50% Human Human +DTXSID5046277 Css NA 3.009 mg/L PBTK NA 95% Human Human +DTXSID5046277 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046277 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046277 Vd NA 0.4798 L/kg 1compartment NA NA Rat Human DTXSID5046277 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046277 TK.Half.Life NA 8.158 hours 1compartment NA NA Rat Human -DTXSID5046277 Css NA 4.003 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046277 Css NA 13.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046277 Css NA 2.259 mg/L PBTK NA 50% Rat Human -DTXSID5046277 Css NA 7.28 mg/L PBTK NA 95% Rat Human -DTXSID5046279 Clint NA 13.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046279 Fup NA 0.0285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046279 Vd NA 0.8832 L/kg 1compartment NA NA Human Human +DTXSID5046277 TK.Half.Life NA 1.476 hours 1compartment NA NA Rat Human +DTXSID5046277 Css NA 0.08372 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046277 Css NA 0.4476 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046277 Css NA 0.05201 mg/L PBTK NA 50% Rat Human +DTXSID5046277 Css NA 0.262 mg/L PBTK NA 95% Rat Human +DTXSID5046279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046279 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046279 Vd NA 1.014 L/kg 1compartment NA NA Human Human DTXSID5046279 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046279 TK.Half.Life NA 8.847 hours 1compartment NA NA Human Human -DTXSID5046279 Css NA 1.682 mg/L 3compartmentss NA 50% Human Human -DTXSID5046279 Css NA 15.23 mg/L 3compartmentss NA 95% Human Human -DTXSID5046279 Css NA 1.027 mg/L PBTK NA 50% Human Human -DTXSID5046279 Css NA 9.115 mg/L PBTK NA 95% Human Human -DTXSID5046279 Clint NA 13.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046279 Fup NA 0.0285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046279 Vd NA 0.6671 L/kg 1compartment NA NA Rat Human +DTXSID5046279 TK.Half.Life NA 5.776 hours 1compartment NA NA Human Human +DTXSID5046279 Css NA 0.833 mg/L 3compartmentss NA 50% Human Human +DTXSID5046279 Css NA 6.404 mg/L 3compartmentss NA 95% Human Human +DTXSID5046279 Css NA 0.5145 mg/L PBTK NA 50% Human Human +DTXSID5046279 Css NA 3.877 mg/L PBTK NA 95% Human Human +DTXSID5046279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046279 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046279 Vd NA 0.7654 L/kg 1compartment NA NA Rat Human DTXSID5046279 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046279 TK.Half.Life NA 4 hours 1compartment NA NA Rat Human -DTXSID5046279 Css NA 0.9432 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046279 Css NA 6.598 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046279 Css NA 0.5372 mg/L PBTK NA 50% Rat Human -DTXSID5046279 Css NA 3.65 mg/L PBTK NA 95% Rat Human -DTXSID5046300 Clint NA 55.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046300 Fup NA 0.0123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046300 Vd NA 0.1982 L/kg 1compartment NA NA Human Human +DTXSID5046279 TK.Half.Life NA 2.526 hours 1compartment NA NA Rat Human +DTXSID5046279 Css NA 0.1088 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046279 Css NA 0.6394 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046279 Css NA 0.0652 mg/L PBTK NA 50% Rat Human +DTXSID5046279 Css NA 0.374 mg/L PBTK NA 95% Rat Human +DTXSID5046300 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046300 Fup 0.025 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046300 Vd NA 0.2604 L/kg 1compartment NA NA Human Human DTXSID5046300 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046300 TK.Half.Life NA 1.306 hours 1compartment NA NA Human Human -DTXSID5046300 Css NA 1.098 mg/L 3compartmentss NA 50% Human Human -DTXSID5046300 Css NA 10.86 mg/L 3compartmentss NA 95% Human Human -DTXSID5046300 Css NA 0.6444 mg/L PBTK NA 50% Human Human -DTXSID5046300 Css NA 6.25 mg/L PBTK NA 95% Human Human -DTXSID5046300 Clint NA 55.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046300 Fup NA 0.0123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046300 Vd NA 0.1921 L/kg 1compartment NA NA Rat Human +DTXSID5046300 TK.Half.Life NA 2.031 hours 1compartment NA NA Human Human +DTXSID5046300 Css NA 1.274 mg/L 3compartmentss NA 50% Human Human +DTXSID5046300 Css NA 12.63 mg/L 3compartmentss NA 95% Human Human +DTXSID5046300 Css NA 0.7694 mg/L PBTK NA 50% Human Human +DTXSID5046300 Css NA 7.439 mg/L PBTK NA 95% Human Human +DTXSID5046300 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046300 Fup 0.025 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046300 Vd NA 0.2462 L/kg 1compartment NA NA Rat Human DTXSID5046300 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046300 TK.Half.Life NA 0.8301 hours 1compartment NA NA Rat Human -DTXSID5046300 Css NA 0.6354 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046300 Css NA 5.184 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046300 Css NA 0.3476 mg/L PBTK NA 50% Rat Human -DTXSID5046300 Css NA 2.821 mg/L PBTK NA 95% Rat Human -DTXSID5046306 Clint NA 42.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046306 Fup NA 0.5909 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046306 Vd NA 2.557 L/kg 1compartment NA NA Human Human +DTXSID5046300 TK.Half.Life NA 1.25 hours 1compartment NA NA Rat Human +DTXSID5046300 Css NA 0.1669 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046300 Css NA 1.27 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046300 Css NA 0.09713 mg/L PBTK NA 50% Rat Human +DTXSID5046300 Css NA 0.7249 mg/L PBTK NA 95% Rat Human +DTXSID5046306 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046306 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046306 Vd NA 1.59 L/kg 1compartment NA NA Human Human DTXSID5046306 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046306 TK.Half.Life NA 1.511 hours 1compartment NA NA Human Human -DTXSID5046306 Css NA 0.01367 mg/L 3compartmentss NA 50% Human Human -DTXSID5046306 Css NA 0.166 mg/L 3compartmentss NA 95% Human Human -DTXSID5046306 Css NA 0.01507 mg/L PBTK NA 50% Human Human -DTXSID5046306 Css NA 0.134 mg/L PBTK NA 95% Human Human -DTXSID5046306 Clint NA 42.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046306 Fup NA 0.5909 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046306 Vd NA 2.561 L/kg 1compartment NA NA Rat Human +DTXSID5046306 TK.Half.Life NA 2.755 hours 1compartment NA NA Human Human +DTXSID5046306 Css NA 0.1166 mg/L 3compartmentss NA 50% Human Human +DTXSID5046306 Css NA 0.9523 mg/L 3compartmentss NA 95% Human Human +DTXSID5046306 Css NA 0.1069 mg/L PBTK NA 50% Human Human +DTXSID5046306 Css NA 0.6934 mg/L PBTK NA 95% Human Human +DTXSID5046306 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046306 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046306 Vd NA 1.584 L/kg 1compartment NA NA Rat Human DTXSID5046306 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046306 TK.Half.Life NA 0.7415 hours 1compartment NA NA Rat Human -DTXSID5046306 Css NA 0.006877 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046306 Css NA 0.08131 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046306 Css NA 0.007582 mg/L PBTK NA 50% Rat Human -DTXSID5046306 Css NA 0.06015 mg/L PBTK NA 95% Rat Human -DTXSID5046308 Clint NA 5.488 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046308 Fup NA 0.2897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046308 Vd NA 1.849 L/kg 1compartment NA NA Human Human -DTXSID5046308 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046308 TK.Half.Life NA 6.789 hours 1compartment NA NA Human Human -DTXSID5046308 Css NA 0.3594 mg/L 3compartmentss NA 50% Human Human -DTXSID5046308 Css NA 1.935 mg/L 3compartmentss NA 95% Human Human -DTXSID5046308 Css NA 0.2708 mg/L PBTK NA 50% Human Human -DTXSID5046308 Css NA 1.352 mg/L PBTK NA 95% Human Human -DTXSID5046308 Clint NA 5.488 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046308 Fup NA 0.2897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046308 Vd NA 1.458 L/kg 1compartment NA NA Rat Human -DTXSID5046308 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046308 TK.Half.Life NA 2.42 hours 1compartment NA NA Rat Human -DTXSID5046308 Css NA 0.1807 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046308 Css NA 0.7325 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046308 Css NA 0.1327 mg/L PBTK NA 50% Rat Human -DTXSID5046308 Css NA 0.4709 mg/L PBTK NA 95% Rat Human -DTXSID5046352 Clint NA 12.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046352 Fup NA 0.1916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046352 Vd NA 0.7068 L/kg 1compartment NA NA Human Human -DTXSID5046352 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046352 TK.Half.Life NA 1.624 hours 1compartment NA NA Human Human -DTXSID5046352 Css NA 0.1968 mg/L 3compartmentss NA 50% Human Human -DTXSID5046352 Css NA 1.275 mg/L 3compartmentss NA 95% Human Human -DTXSID5046352 Css NA 0.1358 mg/L PBTK NA 50% Human Human -DTXSID5046352 Css NA 0.838 mg/L PBTK NA 95% Human Human -DTXSID5046352 Clint NA 12.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046352 Fup NA 0.1916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046352 Vd NA 0.701 L/kg 1compartment NA NA Rat Human -DTXSID5046352 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046352 TK.Half.Life NA 0.9369 hours 1compartment NA NA Rat Human -DTXSID5046352 Css NA 0.1056 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046352 Css NA 0.5174 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046352 Css NA 0.06926 mg/L PBTK NA 50% Rat Human -DTXSID5046352 Css NA 0.3182 mg/L PBTK NA 95% Rat Human +DTXSID5046306 TK.Half.Life NA 1.551 hours 1compartment NA NA Rat Human +DTXSID5046306 Css NA 0.01349 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046306 Css NA 0.084 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046306 Css NA 0.01243 mg/L PBTK NA 50% Rat Human +DTXSID5046306 Css NA 0.05901 mg/L PBTK NA 95% Rat Human +DTXSID5046352 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046352 Fup 0.275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046352 Vd NA 1.481 L/kg 1compartment NA NA Human Human +DTXSID5046352 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5046352 TK.Half.Life NA 36.46 hours 1compartment NA NA Human Human +DTXSID5046352 Css NA 2.142 mg/L 3compartmentss NA 50% Human Human +DTXSID5046352 Css NA 8.921 mg/L 3compartmentss NA 95% Human Human +DTXSID5046352 Css NA 1.725 mg/L PBTK NA 50% Human Human +DTXSID5046352 Css NA 5.99 mg/L PBTK NA 95% Human Human +DTXSID5046352 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046352 Fup 0.275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046352 Vd NA 1.422 L/kg 1compartment NA NA Rat Human +DTXSID5046352 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5046352 TK.Half.Life NA 11.53 hours 1compartment NA NA Rat Human +DTXSID5046352 Css NA 0.0497 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046352 Css NA 0.3034 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046352 Css NA 0.04036 mg/L PBTK NA 50% Rat Human +DTXSID5046352 Css NA 0.205 mg/L PBTK NA 95% Rat Human DTXSID5046354 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID5046354 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5046354 Vd NA 0.3764 L/kg 1compartment NA NA Human Human -DTXSID5046354 Days.Css NA 60 Days PBTK NA NA Human Human -DTXSID5046354 TK.Half.Life NA 248 hours 1compartment NA NA Human Human -DTXSID5046354 Css NA 113.7 mg/L 3compartmentss NA 50% Human Human -DTXSID5046354 Css NA 680.7 mg/L 3compartmentss NA 95% Human Human -DTXSID5046354 Css NA 67.07 mg/L PBTK NA 50% Human Human -DTXSID5046354 Css NA 390.9 mg/L PBTK NA 95% Human Human +DTXSID5046354 Vd NA 0.8739 L/kg 1compartment NA NA Human Human +DTXSID5046354 Days.Css NA 165 Days PBTK NA NA Human Human +DTXSID5046354 TK.Half.Life NA 641.2 hours 1compartment NA NA Human Human +DTXSID5046354 Css NA 103.7 mg/L 3compartmentss NA 50% Human Human +DTXSID5046354 Css NA 631.8 mg/L 3compartmentss NA 95% Human Human +DTXSID5046354 Css NA 62.06 mg/L PBTK NA 50% Human Human +DTXSID5046354 Css NA 364.6 mg/L PBTK NA 95% Human Human DTXSID5046354 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID5046354 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5046354 Vd NA 0.3042 L/kg 1compartment NA NA Rat Human -DTXSID5046354 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID5046354 TK.Half.Life NA 67.36 hours 1compartment NA NA Rat Human -DTXSID5046354 Css NA 32.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046354 Css NA 171.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046354 Css NA 17.62 mg/L PBTK NA 50% Rat Human -DTXSID5046354 Css NA 93.01 mg/L PBTK NA 95% Rat Human -DTXSID5046356 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046356 Fup NA 0.8758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046356 Vd NA 1.796 L/kg 1compartment NA NA Human Human +DTXSID5046354 Vd NA 0.6516 L/kg 1compartment NA NA Rat Human +DTXSID5046354 Days.Css NA 37 Days PBTK NA NA Rat Human +DTXSID5046354 TK.Half.Life NA 148.2 hours 1compartment NA NA Rat Human +DTXSID5046354 Css NA 2.582 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046354 Css NA 19.41 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046354 Css NA 1.488 mg/L PBTK NA 50% Rat Human +DTXSID5046354 Css NA 10.92 mg/L PBTK NA 95% Rat Human +DTXSID5046356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046356 Fup 0.793 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046356 Vd NA 1.618 L/kg 1compartment NA NA Human Human DTXSID5046356 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5046356 TK.Half.Life NA 13.27 hours 1compartment NA NA Human Human -DTXSID5046356 Css NA 0.7764 mg/L 3compartmentss NA 50% Human Human -DTXSID5046356 Css NA 4.95 mg/L 3compartmentss NA 95% Human Human -DTXSID5046356 Css NA 0.773 mg/L PBTK NA 50% Human Human -DTXSID5046356 Css NA 3.446 mg/L PBTK NA 95% Human Human -DTXSID5046356 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046356 Fup NA 0.8758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046356 Vd NA 1.832 L/kg 1compartment NA NA Rat Human +DTXSID5046356 TK.Half.Life NA 13.2 hours 1compartment NA NA Human Human +DTXSID5046356 Css NA 0.4624 mg/L 3compartmentss NA 50% Human Human +DTXSID5046356 Css NA 3.378 mg/L 3compartmentss NA 95% Human Human +DTXSID5046356 Css NA 0.4504 mg/L PBTK NA 50% Human Human +DTXSID5046356 Css NA 2.33 mg/L PBTK NA 95% Human Human +DTXSID5046356 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046356 Fup 0.793 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046356 Vd NA 1.652 L/kg 1compartment NA NA Rat Human DTXSID5046356 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046356 TK.Half.Life NA 4.612 hours 1compartment NA NA Rat Human -DTXSID5046356 Css NA 0.1959 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046356 Css NA 1.336 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046356 Css NA 0.1925 mg/L PBTK NA 50% Rat Human -DTXSID5046356 Css NA 0.8545 mg/L PBTK NA 95% Rat Human -DTXSID5046358 Clint NA 2.209 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046358 Fup NA 0.0051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046358 Vd NA 0.5561 L/kg 1compartment NA NA Human Human -DTXSID5046358 Days.Css NA 28 Days PBTK NA NA Human Human -DTXSID5046358 TK.Half.Life NA 128.6 hours 1compartment NA NA Human Human -DTXSID5046358 Css NA 41.61 mg/L 3compartmentss NA 50% Human Human -DTXSID5046358 Css NA 323.8 mg/L 3compartmentss NA 95% Human Human -DTXSID5046358 Css NA 25.08 mg/L PBTK NA 50% Human Human -DTXSID5046358 Css NA 188.2 mg/L PBTK NA 95% Human Human -DTXSID5046358 Clint NA 2.209 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046358 Fup NA 0.0051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046358 Vd NA 0.4415 L/kg 1compartment NA NA Rat Human -DTXSID5046358 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID5046358 TK.Half.Life NA 58.59 hours 1compartment NA NA Rat Human -DTXSID5046358 Css NA 20.28 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046358 Css NA 122.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046358 Css NA 11.47 mg/L PBTK NA 50% Rat Human -DTXSID5046358 Css NA 67.01 mg/L PBTK NA 95% Rat Human +DTXSID5046356 TK.Half.Life NA 4.593 hours 1compartment NA NA Rat Human +DTXSID5046356 Css NA 0.002329 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046356 Css NA 0.01724 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046356 Css NA 0.002219 mg/L PBTK NA 50% Rat Human +DTXSID5046356 Css NA 0.01154 mg/L PBTK NA 95% Rat Human +DTXSID5046358 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046358 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046358 Vd NA 0.6073 L/kg 1compartment NA NA Human Human +DTXSID5046358 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5046358 TK.Half.Life NA 26.71 hours 1compartment NA NA Human Human +DTXSID5046358 Css NA 7.588 mg/L 3compartmentss NA 50% Human Human +DTXSID5046358 Css NA 67.96 mg/L 3compartmentss NA 95% Human Human +DTXSID5046358 Css NA 4.73 mg/L PBTK NA 50% Human Human +DTXSID5046358 Css NA 39.89 mg/L PBTK NA 95% Human Human +DTXSID5046358 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046358 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046358 Vd NA 0.4993 L/kg 1compartment NA NA Rat Human +DTXSID5046358 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5046358 TK.Half.Life NA 13.72 hours 1compartment NA NA Rat Human +DTXSID5046358 Css NA 0.9272 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046358 Css NA 6.586 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046358 Css NA 0.5596 mg/L PBTK NA 50% Rat Human +DTXSID5046358 Css NA 3.78 mg/L PBTK NA 95% Rat Human DTXSID5046433 Clint 1.9 NA uL/min/million hepatocytes NA https://doi.org/10.1016/j.etap.2016.01.017 NA Human Human DTXSID5046433 Fup 0.47 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID5046433 Vd NA 2.768 L/kg 1compartment NA NA Human Human -DTXSID5046433 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5046433 TK.Half.Life NA 16.33 hours 1compartment NA NA Human Human -DTXSID5046433 Css NA 0.7261 mg/L 3compartmentss NA 50% Human Human -DTXSID5046433 Css NA 3.215 mg/L 3compartmentss NA 95% Human Human -DTXSID5046433 Css NA 0.4794 mg/L PBTK NA 50% Human Human -DTXSID5046433 Css NA 2.007 mg/L PBTK NA 95% Human Human +DTXSID5046433 Vd NA 2.33 L/kg 1compartment NA NA Human Human +DTXSID5046433 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046433 TK.Half.Life NA 10.73 hours 1compartment NA NA Human Human +DTXSID5046433 Css NA 0.4872 mg/L 3compartmentss NA 50% Human Human +DTXSID5046433 Css NA 2.292 mg/L 3compartmentss NA 95% Human Human +DTXSID5046433 Css NA 0.349 mg/L PBTK NA 50% Human Human +DTXSID5046433 Css NA 1.647 mg/L PBTK NA 95% Human Human DTXSID5046433 Clint 1.9 NA uL/min/million hepatocytes NA https://doi.org/10.1016/j.etap.2016.01.017 NA Rat Human DTXSID5046433 Fup 0.47 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human -DTXSID5046433 Vd NA 2.378 L/kg 1compartment NA NA Rat Human +DTXSID5046433 Vd NA 2.089 L/kg 1compartment NA NA Rat Human DTXSID5046433 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046433 TK.Half.Life NA 5.204 hours 1compartment NA NA Rat Human -DTXSID5046433 Css NA 0.3281 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046433 Css NA 1.088 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046433 Css NA 0.2059 mg/L PBTK NA 50% Rat Human -DTXSID5046433 Css NA 0.6313 mg/L PBTK NA 95% Rat Human -DTXSID5046435 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5046433 TK.Half.Life NA 4.263 hours 1compartment NA NA Rat Human +DTXSID5046433 Css NA 0.04778 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046433 Css NA 0.1655 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046433 Css NA 0.03562 mg/L PBTK NA 50% Rat Human +DTXSID5046433 Css NA 0.1234 mg/L PBTK NA 95% Rat Human +DTXSID5046435 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5046435 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5046435 Vd NA 0.7799 L/kg 1compartment NA NA Human Human +DTXSID5046435 Vd NA 0.7515 L/kg 1compartment NA NA Human Human DTXSID5046435 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046435 TK.Half.Life NA 5.484 hours 1compartment NA NA Human Human -DTXSID5046435 Css NA 0.8864 mg/L 3compartmentss NA 50% Human Human -DTXSID5046435 Css NA 5.098 mg/L 3compartmentss NA 95% Human Human -DTXSID5046435 Css NA 0.7547 mg/L PBTK NA 50% Human Human -DTXSID5046435 Css NA 3.4 mg/L PBTK NA 95% Human Human -DTXSID5046435 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5046435 TK.Half.Life NA 5.283 hours 1compartment NA NA Human Human +DTXSID5046435 Css NA 0.8794 mg/L 3compartmentss NA 50% Human Human +DTXSID5046435 Css NA 4.986 mg/L 3compartmentss NA 95% Human Human +DTXSID5046435 Css NA 0.737 mg/L PBTK NA 50% Human Human +DTXSID5046435 Css NA 3.227 mg/L PBTK NA 95% Human Human +DTXSID5046435 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5046435 Fup 0.92 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5046435 Vd NA 0.8032 L/kg 1compartment NA NA Rat Human +DTXSID5046435 Vd NA 0.7769 L/kg 1compartment NA NA Rat Human DTXSID5046435 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046435 TK.Half.Life NA 1.925 hours 1compartment NA NA Rat Human -DTXSID5046435 Css NA 0.2272 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046435 Css NA 1.265 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046435 Css NA 0.1883 mg/L PBTK NA 50% Rat Human -DTXSID5046435 Css NA 0.7724 mg/L PBTK NA 95% Rat Human -DTXSID5046437 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5046435 TK.Half.Life NA 1.862 hours 1compartment NA NA Rat Human +DTXSID5046435 Css NA 0.05189 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046435 Css NA 0.2893 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046435 Css NA 0.04398 mg/L PBTK NA 50% Rat Human +DTXSID5046435 Css NA 0.1821 mg/L PBTK NA 95% Rat Human +DTXSID5046437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5046437 Fup 0.53 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5046437 Vd NA 0.6014 L/kg 1compartment NA NA Human Human +DTXSID5046437 Vd NA 0.6005 L/kg 1compartment NA NA Human Human DTXSID5046437 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046437 TK.Half.Life NA 7.354 hours 1compartment NA NA Human Human -DTXSID5046437 Css NA 1.4 mg/L 3compartmentss NA 50% Human Human -DTXSID5046437 Css NA 8.064 mg/L 3compartmentss NA 95% Human Human -DTXSID5046437 Css NA 1.077 mg/L PBTK NA 50% Human Human -DTXSID5046437 Css NA 5.035 mg/L PBTK NA 95% Human Human -DTXSID5046437 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5046437 TK.Half.Life NA 7.343 hours 1compartment NA NA Human Human +DTXSID5046437 Css NA 1.192 mg/L 3compartmentss NA 50% Human Human +DTXSID5046437 Css NA 7.003 mg/L 3compartmentss NA 95% Human Human +DTXSID5046437 Css NA 0.9212 mg/L PBTK NA 50% Human Human +DTXSID5046437 Css NA 4.406 mg/L PBTK NA 95% Human Human +DTXSID5046437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5046437 Fup 0.53 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5046437 Vd NA 0.6156 L/kg 1compartment NA NA Rat Human +DTXSID5046437 Vd NA 0.6147 L/kg 1compartment NA NA Rat Human DTXSID5046437 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046437 TK.Half.Life NA 2.562 hours 1compartment NA NA Rat Human -DTXSID5046437 Css NA 0.3689 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046437 Css NA 1.983 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046437 Css NA 0.272 mg/L PBTK NA 50% Rat Human -DTXSID5046437 Css NA 1.163 mg/L PBTK NA 95% Rat Human -DTXSID5046439 Clint NA 5.805 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5046437 TK.Half.Life NA 2.558 hours 1compartment NA NA Rat Human +DTXSID5046437 Css NA 0.02965 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046437 Css NA 0.2217 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046437 Css NA 0.02243 mg/L PBTK NA 50% Rat Human +DTXSID5046437 Css NA 0.1379 mg/L PBTK NA 95% Rat Human +DTXSID5046439 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5046439 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5046439 Vd NA 0.2014 L/kg 1compartment NA NA Human Human +DTXSID5046439 Vd NA 0.1998 L/kg 1compartment NA NA Human Human DTXSID5046439 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046439 TK.Half.Life NA 6.245 hours 1compartment NA NA Human Human -DTXSID5046439 Css NA 5.858 mg/L 3compartmentss NA 50% Human Human -DTXSID5046439 Css NA 48.36 mg/L 3compartmentss NA 95% Human Human -DTXSID5046439 Css NA 3.368 mg/L PBTK NA 50% Human Human -DTXSID5046439 Css NA 27.46 mg/L PBTK NA 95% Human Human -DTXSID5046439 Clint NA 5.805 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5046439 TK.Half.Life NA 5.81 hours 1compartment NA NA Human Human +DTXSID5046439 Css NA 5.618 mg/L 3compartmentss NA 50% Human Human +DTXSID5046439 Css NA 46.99 mg/L 3compartmentss NA 95% Human Human +DTXSID5046439 Css NA 3.088 mg/L PBTK NA 50% Human Human +DTXSID5046439 Css NA 25.84 mg/L PBTK NA 95% Human Human +DTXSID5046439 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5046439 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5046439 Vd NA 0.192 L/kg 1compartment NA NA Rat Human +DTXSID5046439 Vd NA 0.1909 L/kg 1compartment NA NA Rat Human DTXSID5046439 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046439 TK.Half.Life NA 3.757 hours 1compartment NA NA Rat Human -DTXSID5046439 Css NA 3.122 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046439 Css NA 19.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046439 Css NA 1.662 mg/L PBTK NA 50% Rat Human -DTXSID5046439 Css NA 10.5 mg/L PBTK NA 95% Rat Human -DTXSID5046481 Clint NA 23.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046481 Fup NA 0.0018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046481 Vd NA 2.652 L/kg 1compartment NA NA Human Human -DTXSID5046481 Days.Css NA 25 Days PBTK NA NA Human Human -DTXSID5046481 TK.Half.Life NA 135.4 hours 1compartment NA NA Human Human -DTXSID5046481 Css NA 8.474 mg/L 3compartmentss NA 50% Human Human -DTXSID5046481 Css NA 85.24 mg/L 3compartmentss NA 95% Human Human -DTXSID5046481 Css NA 5.627 mg/L PBTK NA 50% Human Human -DTXSID5046481 Css NA 52.62 mg/L PBTK NA 95% Human Human -DTXSID5046481 Clint NA 23.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046481 Fup NA 0.0018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046481 Vd NA 1.982 L/kg 1compartment NA NA Rat Human -DTXSID5046481 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID5046481 TK.Half.Life NA 64.54 hours 1compartment NA NA Rat Human -DTXSID5046481 Css NA 4.811 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046481 Css NA 38.72 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046481 Css NA 3.007 mg/L PBTK NA 50% Rat Human -DTXSID5046481 Css NA 22.23 mg/L PBTK NA 95% Rat Human -DTXSID5046483 Clint NA 2.235 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046483 Fup NA 0.0631 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046483 Vd NA 0.3001 L/kg 1compartment NA NA Human Human +DTXSID5046439 TK.Half.Life NA 3.52 hours 1compartment NA NA Rat Human +DTXSID5046439 Css NA 0.6314 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046439 Css NA 4.241 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046439 Css NA 0.3596 mg/L PBTK NA 50% Rat Human +DTXSID5046439 Css NA 2.414 mg/L PBTK NA 95% Rat Human +DTXSID5046481 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046481 Fup 0.0105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046481 Vd NA 138.1 L/kg 1compartment NA NA Human Human +DTXSID5046481 Days.Css NA 487 Days PBTK NA NA Human Human +DTXSID5046481 TK.Half.Life NA 1912 hours 1compartment NA NA Human Human +DTXSID5046481 Css NA 0.09929 mg/L 3compartmentss NA 50% Human Human +DTXSID5046481 Css NA 2.197 mg/L 3compartmentss NA 95% Human Human +DTXSID5046481 Css NA 1.471 mg/L PBTK NA 50% Human Human +DTXSID5046481 Css NA 12.43 mg/L PBTK NA 95% Human Human +DTXSID5046481 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046481 Fup 0.0105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046481 Vd NA 120.7 L/kg 1compartment NA NA Rat Human +DTXSID5046481 Days.Css NA 309 Days PBTK NA NA Rat Human +DTXSID5046481 TK.Half.Life NA 817 hours 1compartment NA NA Rat Human +DTXSID5046481 Css NA 0.01139 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046481 Css NA 0.2223 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046481 Css NA 0.1848 mg/L PBTK NA 50% Rat Human +DTXSID5046481 Css NA 1.293 mg/L PBTK NA 95% Rat Human +DTXSID5046483 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046483 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046483 Vd NA 0.8967 L/kg 1compartment NA NA Human Human DTXSID5046483 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046483 TK.Half.Life NA 6.658 hours 1compartment NA NA Human Human -DTXSID5046483 Css NA 3.761 mg/L 3compartmentss NA 50% Human Human -DTXSID5046483 Css NA 22.22 mg/L 3compartmentss NA 95% Human Human -DTXSID5046483 Css NA 2.284 mg/L PBTK NA 50% Human Human -DTXSID5046483 Css NA 12.97 mg/L PBTK NA 95% Human Human -DTXSID5046483 Clint NA 2.235 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046483 Fup NA 0.0631 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046483 Vd NA 0.2748 L/kg 1compartment NA NA Rat Human +DTXSID5046483 TK.Half.Life NA 2.164 hours 1compartment NA NA Human Human +DTXSID5046483 Css NA 0.2062 mg/L 3compartmentss NA 50% Human Human +DTXSID5046483 Css NA 1.252 mg/L 3compartmentss NA 95% Human Human +DTXSID5046483 Css NA 0.1514 mg/L PBTK NA 50% Human Human +DTXSID5046483 Css NA 0.8283 mg/L PBTK NA 95% Human Human +DTXSID5046483 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046483 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046483 Vd NA 0.7695 L/kg 1compartment NA NA Rat Human DTXSID5046483 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046483 TK.Half.Life NA 3.445 hours 1compartment NA NA Rat Human -DTXSID5046483 Css NA 1.796 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046483 Css NA 7.596 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046483 Css NA 1.01 mg/L PBTK NA 50% Rat Human -DTXSID5046483 Css NA 4.166 mg/L PBTK NA 95% Rat Human -DTXSID5046485 Clint NA 7.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5046483 TK.Half.Life NA 1.016 hours 1compartment NA NA Rat Human +DTXSID5046483 Css NA 0.02424 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046483 Css NA 0.1117 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046483 Css NA 0.01766 mg/L PBTK NA 50% Rat Human +DTXSID5046483 Css NA 0.07184 mg/L PBTK NA 95% Rat Human +DTXSID5046485 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID5046485 Fup 0.42 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5046485 Vd NA 1.726 L/kg 1compartment NA NA Human Human +DTXSID5046485 Vd NA 1.867 L/kg 1compartment NA NA Human Human DTXSID5046485 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046485 TK.Half.Life NA 3.689 hours 1compartment NA NA Human Human -DTXSID5046485 Css NA 0.1729 mg/L 3compartmentss NA 50% Human Human -DTXSID5046485 Css NA 1.07 mg/L 3compartmentss NA 95% Human Human -DTXSID5046485 Css NA 0.1399 mg/L PBTK NA 50% Human Human -DTXSID5046485 Css NA 0.7804 mg/L PBTK NA 95% Human Human -DTXSID5046485 Clint NA 7.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5046485 TK.Half.Life NA 5.259 hours 1compartment NA NA Human Human +DTXSID5046485 Css NA 0.2422 mg/L 3compartmentss NA 50% Human Human +DTXSID5046485 Css NA 1.445 mg/L 3compartmentss NA 95% Human Human +DTXSID5046485 Css NA 0.1946 mg/L PBTK NA 50% Human Human +DTXSID5046485 Css NA 1.032 mg/L PBTK NA 95% Human Human +DTXSID5046485 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID5046485 Fup 0.42 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5046485 Vd NA 1.406 L/kg 1compartment NA NA Rat Human +DTXSID5046485 Vd NA 1.505 L/kg 1compartment NA NA Rat Human DTXSID5046485 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046485 TK.Half.Life NA 1.433 hours 1compartment NA NA Rat Human -DTXSID5046485 Css NA 0.08822 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046485 Css NA 0.4071 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046485 Css NA 0.06911 mg/L PBTK NA 50% Rat Human -DTXSID5046485 Css NA 0.2724 mg/L PBTK NA 95% Rat Human +DTXSID5046485 TK.Half.Life NA 1.922 hours 1compartment NA NA Rat Human +DTXSID5046485 Css NA 0.02738 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046485 Css NA 0.126 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046485 Css NA 0.02219 mg/L PBTK NA 50% Rat Human +DTXSID5046485 Css NA 0.08651 mg/L PBTK NA 95% Rat Human DTXSID5046487 Clint 6.3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID5046487 Fup NA 0.124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046487 Vd NA 0.383 L/kg 1compartment NA NA Human Human +DTXSID5046487 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046487 Vd NA 2.301 L/kg 1compartment NA NA Human Human DTXSID5046487 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046487 TK.Half.Life NA 2.016 hours 1compartment NA NA Human Human -DTXSID5046487 Css NA 0.7176 mg/L 3compartmentss NA 50% Human Human -DTXSID5046487 Css NA 4.988 mg/L 3compartmentss NA 95% Human Human -DTXSID5046487 Css NA 0.4624 mg/L PBTK NA 50% Human Human -DTXSID5046487 Css NA 3.003 mg/L PBTK NA 95% Human Human +DTXSID5046487 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human +DTXSID5046487 Css NA 0.1972 mg/L 3compartmentss NA 50% Human Human +DTXSID5046487 Css NA 1.224 mg/L 3compartmentss NA 95% Human Human +DTXSID5046487 Css NA 0.1597 mg/L PBTK NA 50% Human Human +DTXSID5046487 Css NA 0.8929 mg/L PBTK NA 95% Human Human DTXSID5046487 Clint 6.3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID5046487 Fup NA 0.124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046487 Vd NA 0.363 L/kg 1compartment NA NA Rat Human +DTXSID5046487 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046487 Vd NA 1.819 L/kg 1compartment NA NA Rat Human DTXSID5046487 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046487 TK.Half.Life NA 1.152 hours 1compartment NA NA Rat Human -DTXSID5046487 Css NA 0.3823 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046487 Css NA 1.953 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046487 Css NA 0.2298 mg/L PBTK NA 50% Rat Human -DTXSID5046487 Css NA 1.12 mg/L PBTK NA 95% Rat Human -DTXSID5046489 Clint NA 26.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5046487 TK.Half.Life NA 1.922 hours 1compartment NA NA Rat Human +DTXSID5046487 Css NA 0.008802 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046487 Css NA 0.05991 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046487 Css NA 0.007158 mg/L PBTK NA 50% Rat Human +DTXSID5046487 Css NA 0.04316 mg/L PBTK NA 95% Rat Human +DTXSID5046489 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5046489 Fup 0.69 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5046489 Vd NA 0.7819 L/kg 1compartment NA NA Human Human +DTXSID5046489 Vd NA 1.055 L/kg 1compartment NA NA Human Human DTXSID5046489 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046489 TK.Half.Life NA 0.6957 hours 1compartment NA NA Human Human -DTXSID5046489 Css NA 0.03053 mg/L 3compartmentss NA 50% Human Human -DTXSID5046489 Css NA 0.2958 mg/L 3compartmentss NA 95% Human Human -DTXSID5046489 Css NA 0.02178 mg/L PBTK NA 50% Human Human -DTXSID5046489 Css NA 0.1966 mg/L PBTK NA 95% Human Human -DTXSID5046489 Clint NA 26.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5046489 TK.Half.Life NA 1.521 hours 1compartment NA NA Human Human +DTXSID5046489 Css NA 0.1109 mg/L 3compartmentss NA 50% Human Human +DTXSID5046489 Css NA 0.8071 mg/L 3compartmentss NA 95% Human Human +DTXSID5046489 Css NA 0.08016 mg/L PBTK NA 50% Human Human +DTXSID5046489 Css NA 0.5874 mg/L PBTK NA 95% Human Human +DTXSID5046489 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5046489 Fup 0.69 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5046489 Vd NA 0.7872 L/kg 1compartment NA NA Rat Human +DTXSID5046489 Vd NA 0.9975 L/kg 1compartment NA NA Rat Human DTXSID5046489 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046489 TK.Half.Life NA 0.3331 hours 1compartment NA NA Rat Human -DTXSID5046489 Css NA 0.01568 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046489 Css NA 0.1331 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046489 Css NA 0.01088 mg/L PBTK NA 50% Rat Human -DTXSID5046489 Css NA 0.08316 mg/L PBTK NA 95% Rat Human -DTXSID5046510 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046510 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046510 Vd NA 0.8055 L/kg 1compartment NA NA Human Human +DTXSID5046489 TK.Half.Life NA 0.7428 hours 1compartment NA NA Rat Human +DTXSID5046489 Css NA 0.01197 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046489 Css NA 0.07621 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046489 Css NA 0.009053 mg/L PBTK NA 50% Rat Human +DTXSID5046489 Css NA 0.05762 mg/L PBTK NA 95% Rat Human +DTXSID5046510 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046510 Fup 0.889 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046510 Vd NA 0.6891 L/kg 1compartment NA NA Human Human DTXSID5046510 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046510 TK.Half.Life NA 5.219 hours 1compartment NA NA Human Human -DTXSID5046510 Css NA 0.8206 mg/L 3compartmentss NA 50% Human Human -DTXSID5046510 Css NA 5.489 mg/L 3compartmentss NA 95% Human Human -DTXSID5046510 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID5046510 Css NA 3.549 mg/L PBTK NA 95% Human Human -DTXSID5046510 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046510 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046510 Vd NA 0.839 L/kg 1compartment NA NA Rat Human +DTXSID5046510 TK.Half.Life NA 5.016 hours 1compartment NA NA Human Human +DTXSID5046510 Css NA 0.9167 mg/L 3compartmentss NA 50% Human Human +DTXSID5046510 Css NA 5.121 mg/L 3compartmentss NA 95% Human Human +DTXSID5046510 Css NA 0.7463 mg/L PBTK NA 50% Human Human +DTXSID5046510 Css NA 3.332 mg/L PBTK NA 95% Human Human +DTXSID5046510 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046510 Fup 0.889 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046510 Vd NA 0.7289 L/kg 1compartment NA NA Rat Human DTXSID5046510 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046510 TK.Half.Life NA 1.85 hours 1compartment NA NA Rat Human -DTXSID5046510 Css NA 0.2063 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046510 Css NA 1.282 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046510 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID5046510 Css NA 0.7759 mg/L PBTK NA 95% Rat Human -DTXSID5046512 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046512 Fup NA 0.8759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046512 Vd NA 0.6994 L/kg 1compartment NA NA Human Human +DTXSID5046510 TK.Half.Life NA 1.807 hours 1compartment NA NA Rat Human +DTXSID5046510 Css NA 0.05446 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046510 Css NA 0.3027 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046510 Css NA 0.04453 mg/L PBTK NA 50% Rat Human +DTXSID5046510 Css NA 0.1879 mg/L PBTK NA 95% Rat Human +DTXSID5046512 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046512 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046512 Vd NA 0.703 L/kg 1compartment NA NA Human Human DTXSID5046512 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046512 TK.Half.Life NA 5.169 hours 1compartment NA NA Human Human -DTXSID5046512 Css NA 0.9486 mg/L 3compartmentss NA 50% Human Human -DTXSID5046512 Css NA 5.263 mg/L 3compartmentss NA 95% Human Human -DTXSID5046512 Css NA 0.7746 mg/L PBTK NA 50% Human Human -DTXSID5046512 Css NA 3.436 mg/L PBTK NA 95% Human Human -DTXSID5046512 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046512 Fup NA 0.8759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046512 Vd NA 0.7358 L/kg 1compartment NA NA Rat Human +DTXSID5046512 TK.Half.Life NA 7.368 hours 1compartment NA NA Human Human +DTXSID5046512 Css NA 1.018 mg/L 3compartmentss NA 50% Human Human +DTXSID5046512 Css NA 7.064 mg/L 3compartmentss NA 95% Human Human +DTXSID5046512 Css NA 0.8173 mg/L PBTK NA 50% Human Human +DTXSID5046512 Css NA 4.396 mg/L PBTK NA 95% Human Human +DTXSID5046512 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046512 Fup 0.62 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046512 Vd NA 0.7108 L/kg 1compartment NA NA Rat Human DTXSID5046512 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046512 TK.Half.Life NA 1.852 hours 1compartment NA NA Rat Human -DTXSID5046512 Css NA 0.2432 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046512 Css NA 1.433 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046512 Css NA 0.1926 mg/L PBTK NA 50% Rat Human -DTXSID5046512 Css NA 0.8552 mg/L PBTK NA 95% Rat Human -DTXSID5046518 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046518 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046518 Vd NA 0.6449 L/kg 1compartment NA NA Human Human -DTXSID5046518 TK.Half.Life NA NA hours 1compartment NA NA Human Human -DTXSID5046518 Css NA NA mg/L 3compartmentss NA 50% Human Human -DTXSID5046518 Css NA NA mg/L 3compartmentss NA 95% Human Human -DTXSID5046518 Css NA NA mg/L PBTK NA 50% Human Human -DTXSID5046518 Css NA NA mg/L PBTK NA 95% Human Human -DTXSID5046518 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046518 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046518 Vd NA 0.7068 L/kg 1compartment NA NA Rat Human -DTXSID5046518 TK.Half.Life NA NA hours 1compartment NA NA Rat Human -DTXSID5046518 Css NA NA mg/L 3compartmentss NA 50% Rat Human -DTXSID5046518 Css NA NA mg/L 3compartmentss NA 95% Rat Human -DTXSID5046518 Css NA NA mg/L PBTK NA 50% Rat Human -DTXSID5046518 Css NA NA mg/L PBTK NA 95% Rat Human -DTXSID5046562 Clint NA 1.522 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046562 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046562 Vd NA 2.148 L/kg 1compartment NA NA Human Human -DTXSID5046562 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046562 TK.Half.Life NA 5.324 hours 1compartment NA NA Human Human -DTXSID5046562 Css NA 0.225 mg/L 3compartmentss NA 50% Human Human -DTXSID5046562 Css NA 1.692 mg/L 3compartmentss NA 95% Human Human -DTXSID5046562 Css NA 0.236 mg/L PBTK NA 50% Human Human -DTXSID5046562 Css NA 1.264 mg/L PBTK NA 95% Human Human -DTXSID5046562 Clint NA 1.522 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046562 Fup NA 0.8181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046562 Vd NA 2.161 L/kg 1compartment NA NA Rat Human +DTXSID5046512 TK.Half.Life NA 2.531 hours 1compartment NA NA Rat Human +DTXSID5046512 Css NA 0.01965 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046512 Css NA 0.1723 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046512 Css NA 0.01507 mg/L PBTK NA 50% Rat Human +DTXSID5046512 Css NA 0.1067 mg/L PBTK NA 95% Rat Human +DTXSID5046562 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046562 Fup 0.437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046562 Vd NA 1.402 L/kg 1compartment NA NA Human Human +DTXSID5046562 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5046562 TK.Half.Life NA 20.75 hours 1compartment NA NA Human Human +DTXSID5046562 Css NA 1.202 mg/L 3compartmentss NA 50% Human Human +DTXSID5046562 Css NA 6.019 mg/L 3compartmentss NA 95% Human Human +DTXSID5046562 Css NA 1.053 mg/L PBTK NA 50% Human Human +DTXSID5046562 Css NA 4.12 mg/L PBTK NA 95% Human Human +DTXSID5046562 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046562 Fup 0.437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046562 Vd NA 1.4 L/kg 1compartment NA NA Rat Human DTXSID5046562 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046562 TK.Half.Life NA 2.748 hours 1compartment NA NA Rat Human -DTXSID5046562 Css NA 0.08858 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046562 Css NA 0.6797 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046562 Css NA 0.09317 mg/L PBTK NA 50% Rat Human -DTXSID5046562 Css NA 0.4535 mg/L PBTK NA 95% Rat Human -DTXSID5046564 Clint NA 0.8216 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046564 Fup NA 0.0337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046564 Vd NA 0.2923 L/kg 1compartment NA NA Human Human -DTXSID5046564 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5046564 TK.Half.Life NA 23.79 hours 1compartment NA NA Human Human -DTXSID5046564 Css NA 14.44 mg/L 3compartmentss NA 50% Human Human -DTXSID5046564 Css NA 73.81 mg/L 3compartmentss NA 95% Human Human -DTXSID5046564 Css NA 8.79 mg/L PBTK NA 50% Human Human -DTXSID5046564 Css NA 43.25 mg/L PBTK NA 95% Human Human -DTXSID5046564 Clint NA 0.8216 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046564 Fup NA 0.0337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046564 Vd NA 0.282 L/kg 1compartment NA NA Rat Human -DTXSID5046564 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5046564 TK.Half.Life NA 11.11 hours 1compartment NA NA Rat Human -DTXSID5046564 Css NA 5.914 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046564 Css NA 24.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046564 Css NA 3.354 mg/L PBTK NA 50% Rat Human -DTXSID5046564 Css NA 13.34 mg/L PBTK NA 95% Rat Human +DTXSID5046562 TK.Half.Life NA 7.063 hours 1compartment NA NA Rat Human +DTXSID5046562 Css NA 0.02162 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046562 Css NA 0.1568 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046562 Css NA 0.01865 mg/L PBTK NA 50% Rat Human +DTXSID5046562 Css NA 0.1113 mg/L PBTK NA 95% Rat Human +DTXSID5046564 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046564 Fup 0.0697 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046564 Vd NA 0.399 L/kg 1compartment NA NA Human Human +DTXSID5046564 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046564 TK.Half.Life NA 1.326 hours 1compartment NA NA Human Human +DTXSID5046564 Css NA 0.4139 mg/L 3compartmentss NA 50% Human Human +DTXSID5046564 Css NA 3.324 mg/L 3compartmentss NA 95% Human Human +DTXSID5046564 Css NA 0.2629 mg/L PBTK NA 50% Human Human +DTXSID5046564 Css NA 2.021 mg/L PBTK NA 95% Human Human +DTXSID5046564 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046564 Fup 0.0697 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046564 Vd NA 0.3862 L/kg 1compartment NA NA Rat Human +DTXSID5046564 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5046564 TK.Half.Life NA 0.7901 hours 1compartment NA NA Rat Human +DTXSID5046564 Css NA 0.05378 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046564 Css NA 0.3354 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046564 Css NA 0.0336 mg/L PBTK NA 50% Rat Human +DTXSID5046564 Css NA 0.1984 mg/L PBTK NA 95% Rat Human DTXSID5046568 Clint NA 0.01461 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5046568 Fup NA 0.5521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046568 Vd NA 0.4911 L/kg 1compartment NA NA Human Human +DTXSID5046568 Vd NA 0.4825 L/kg 1compartment NA NA Human Human DTXSID5046568 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046568 TK.Half.Life NA 5.622 hours 1compartment NA NA Human Human -DTXSID5046568 Css NA 1.359 mg/L 3compartmentss NA 50% Human Human -DTXSID5046568 Css NA 8.43 mg/L 3compartmentss NA 95% Human Human -DTXSID5046568 Css NA 1.009 mg/L PBTK NA 50% Human Human -DTXSID5046568 Css NA 5.255 mg/L PBTK NA 95% Human Human +DTXSID5046568 TK.Half.Life NA 5.519 hours 1compartment NA NA Human Human +DTXSID5046568 Css NA 0.7338 mg/L 3compartmentss NA 50% Human Human +DTXSID5046568 Css NA 4.831 mg/L 3compartmentss NA 95% Human Human +DTXSID5046568 Css NA 0.5442 mg/L PBTK NA 50% Human Human +DTXSID5046568 Css NA 2.977 mg/L PBTK NA 95% Human Human DTXSID5046568 Clint NA 0.01461 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5046568 Fup NA 0.5521 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046568 Vd NA 0.5133 L/kg 1compartment NA NA Rat Human +DTXSID5046568 Vd NA 0.5061 L/kg 1compartment NA NA Rat Human DTXSID5046568 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046568 TK.Half.Life NA 2.026 hours 1compartment NA NA Rat Human -DTXSID5046568 Css NA 0.3678 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046568 Css NA 2.181 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046568 Css NA 0.2597 mg/L PBTK NA 50% Rat Human -DTXSID5046568 Css NA 1.252 mg/L PBTK NA 95% Rat Human -DTXSID5046641 Clint NA 1584 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046641 Fup NA 0.0623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046641 Vd NA 2.915 L/kg 1compartment NA NA Human Human +DTXSID5046568 TK.Half.Life NA 1.998 hours 1compartment NA NA Rat Human +DTXSID5046568 Css NA 0.004033 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046568 Css NA 0.0273 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046568 Css NA 0.002843 mg/L PBTK NA 50% Rat Human +DTXSID5046568 Css NA 0.01598 mg/L PBTK NA 95% Rat Human +DTXSID5046641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046641 Fup 0.0643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046641 Vd NA 2.196 L/kg 1compartment NA NA Human Human DTXSID5046641 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046641 TK.Half.Life NA 2.713 hours 1compartment NA NA Human Human -DTXSID5046641 Css NA 0.01558 mg/L 3compartmentss NA 50% Human Human -DTXSID5046641 Css NA 0.09906 mg/L 3compartmentss NA 95% Human Human -DTXSID5046641 Css NA 0.01077 mg/L PBTK NA 50% Human Human -DTXSID5046641 Css NA 0.06547 mg/L PBTK NA 95% Human Human -DTXSID5046641 Clint NA 1584 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046641 Fup NA 0.0623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046641 Vd NA 2.201 L/kg 1compartment NA NA Rat Human +DTXSID5046641 TK.Half.Life NA 10.35 hours 1compartment NA NA Human Human +DTXSID5046641 Css NA 0.4977 mg/L 3compartmentss NA 50% Human Human +DTXSID5046641 Css NA 3.471 mg/L 3compartmentss NA 95% Human Human +DTXSID5046641 Css NA 0.3369 mg/L PBTK NA 50% Human Human +DTXSID5046641 Css NA 2.244 mg/L PBTK NA 95% Human Human +DTXSID5046641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046641 Fup 0.0643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046641 Vd NA 1.684 L/kg 1compartment NA NA Rat Human DTXSID5046641 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046641 TK.Half.Life NA 0.8439 hours 1compartment NA NA Rat Human -DTXSID5046641 Css NA 0.008692 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046641 Css NA 0.04878 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046641 Css NA 0.005789 mg/L PBTK NA 50% Rat Human -DTXSID5046641 Css NA 0.03057 mg/L PBTK NA 95% Rat Human -DTXSID5046643 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046643 Fup NA 0.5242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046643 Vd NA 0.4571 L/kg 1compartment NA NA Human Human +DTXSID5046641 TK.Half.Life NA 3.329 hours 1compartment NA NA Rat Human +DTXSID5046641 Css NA 0.02442 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046641 Css NA 0.1862 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046641 Css NA 0.01617 mg/L PBTK NA 50% Rat Human +DTXSID5046641 Css NA 0.1148 mg/L PBTK NA 95% Rat Human +DTXSID5046643 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046643 Fup 0.384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046643 Vd NA 0.3588 L/kg 1compartment NA NA Human Human DTXSID5046643 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046643 TK.Half.Life NA 5.645 hours 1compartment NA NA Human Human -DTXSID5046643 Css NA 1.508 mg/L 3compartmentss NA 50% Human Human -DTXSID5046643 Css NA 8.075 mg/L 3compartmentss NA 95% Human Human -DTXSID5046643 Css NA 1.079 mg/L PBTK NA 50% Human Human -DTXSID5046643 Css NA 5.014 mg/L PBTK NA 95% Human Human -DTXSID5046643 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046643 Fup NA 0.5242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046643 Vd NA 0.4669 L/kg 1compartment NA NA Rat Human +DTXSID5046643 TK.Half.Life NA 6.043 hours 1compartment NA NA Human Human +DTXSID5046643 Css NA 1.103 mg/L 3compartmentss NA 50% Human Human +DTXSID5046643 Css NA 4.836 mg/L 3compartmentss NA 95% Human Human +DTXSID5046643 Css NA 0.75 mg/L PBTK NA 50% Human Human +DTXSID5046643 Css NA 2.946 mg/L PBTK NA 95% Human Human +DTXSID5046643 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046643 Fup 0.384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046643 Vd NA 0.3707 L/kg 1compartment NA NA Rat Human DTXSID5046643 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046643 TK.Half.Life NA 1.964 hours 1compartment NA NA Rat Human -DTXSID5046643 Css NA 0.4037 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046643 Css NA 1.943 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046643 Css NA 0.2761 mg/L PBTK NA 50% Rat Human -DTXSID5046643 Css NA 1.118 mg/L PBTK NA 95% Rat Human -DTXSID5046647 Clint NA 7.273 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046647 Fup NA 0.2254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046647 Vd NA 0.9625 L/kg 1compartment NA NA Human Human -DTXSID5046647 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046647 TK.Half.Life NA 2.775 hours 1compartment NA NA Human Human -DTXSID5046647 Css NA 0.2688 mg/L 3compartmentss NA 50% Human Human -DTXSID5046647 Css NA 1.65 mg/L 3compartmentss NA 95% Human Human -DTXSID5046647 Css NA 0.1937 mg/L PBTK NA 50% Human Human -DTXSID5046647 Css NA 1.084 mg/L PBTK NA 95% Human Human -DTXSID5046647 Clint NA 7.273 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046647 Fup NA 0.2254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046647 Vd NA 0.8799 L/kg 1compartment NA NA Rat Human +DTXSID5046643 TK.Half.Life NA 2.129 hours 1compartment NA NA Rat Human +DTXSID5046643 Css NA 0.005946 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046643 Css NA 0.02608 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046643 Css NA 0.003842 mg/L PBTK NA 50% Rat Human +DTXSID5046643 Css NA 0.01515 mg/L PBTK NA 95% Rat Human +DTXSID5046647 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046647 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046647 Vd NA 1.126 L/kg 1compartment NA NA Human Human +DTXSID5046647 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5046647 TK.Half.Life NA 17.79 hours 1compartment NA NA Human Human +DTXSID5046647 Css NA 0.867 mg/L 3compartmentss NA 50% Human Human +DTXSID5046647 Css NA 4.343 mg/L 3compartmentss NA 95% Human Human +DTXSID5046647 Css NA 0.71 mg/L PBTK NA 50% Human Human +DTXSID5046647 Css NA 2.883 mg/L PBTK NA 95% Human Human +DTXSID5046647 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046647 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046647 Vd NA 1.075 L/kg 1compartment NA NA Rat Human DTXSID5046647 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046647 TK.Half.Life NA 1.451 hours 1compartment NA NA Rat Human -DTXSID5046647 Css NA 0.1389 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046647 Css NA 0.6343 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046647 Css NA 0.09643 mg/L PBTK NA 50% Rat Human -DTXSID5046647 Css NA 0.3922 mg/L PBTK NA 95% Rat Human +DTXSID5046647 TK.Half.Life NA 5.649 hours 1compartment NA NA Rat Human +DTXSID5046647 Css NA 0.004623 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046647 Css NA 0.02349 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046647 Css NA 0.003636 mg/L PBTK NA 50% Rat Human +DTXSID5046647 Css NA 0.01498 mg/L PBTK NA 95% Rat Human DTXSID5046649 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5046649 Fup NA 0.4345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046649 Vd NA 2.858 L/kg 1compartment NA NA Human Human -DTXSID5046649 Days.Css NA 47 Days PBTK NA NA Human Human -DTXSID5046649 TK.Half.Life NA 223.5 hours 1compartment NA NA Human Human -DTXSID5046649 Css NA 8.038 mg/L 3compartmentss NA 50% Human Human -DTXSID5046649 Css NA 23.96 mg/L 3compartmentss NA 95% Human Human -DTXSID5046649 Css NA 6.386 mg/L PBTK NA 50% Human Human -DTXSID5046649 Css NA 17.01 mg/L PBTK NA 95% Human Human +DTXSID5046649 Vd NA 0.5323 L/kg 1compartment NA NA Human Human +DTXSID5046649 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046649 TK.Half.Life NA 7.975 hours 1compartment NA NA Human Human +DTXSID5046649 Css NA 1.44 mg/L 3compartmentss NA 50% Human Human +DTXSID5046649 Css NA 6.788 mg/L 3compartmentss NA 95% Human Human +DTXSID5046649 Css NA 1.071 mg/L PBTK NA 50% Human Human +DTXSID5046649 Css NA 4.316 mg/L PBTK NA 95% Human Human DTXSID5046649 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5046649 Fup NA 0.4345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046649 Vd NA 2.193 L/kg 1compartment NA NA Rat Human -DTXSID5046649 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID5046649 TK.Half.Life NA 22.41 hours 1compartment NA NA Rat Human -DTXSID5046649 Css NA 2.152 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046649 Css NA 5.271 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046649 Css NA 1.658 mg/L PBTK NA 50% Rat Human -DTXSID5046649 Css NA 3.433 mg/L PBTK NA 95% Rat Human -DTXSID5046691 Clint NA 29.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046691 Fup NA 0.0127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046691 Vd NA 2.314 L/kg 1compartment NA NA Human Human -DTXSID5046691 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5046691 TK.Half.Life NA 25.95 hours 1compartment NA NA Human Human -DTXSID5046691 Css NA 1.644 mg/L 3compartmentss NA 50% Human Human -DTXSID5046691 Css NA 12.94 mg/L 3compartmentss NA 95% Human Human -DTXSID5046691 Css NA 1.077 mg/L PBTK NA 50% Human Human -DTXSID5046691 Css NA 8.077 mg/L PBTK NA 95% Human Human -DTXSID5046691 Clint NA 29.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046691 Fup NA 0.0127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046691 Vd NA 1.721 L/kg 1compartment NA NA Rat Human -DTXSID5046691 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5046691 TK.Half.Life NA 7.164 hours 1compartment NA NA Rat Human -DTXSID5046691 Css NA 0.9176 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046691 Css NA 6.075 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046691 Css NA 0.5674 mg/L PBTK NA 50% Rat Human -DTXSID5046691 Css NA 3.58 mg/L PBTK NA 95% Rat Human -DTXSID5046693 Clint NA 47.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046693 Fup NA 0.1643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046693 Vd NA 1.656 L/kg 1compartment NA NA Human Human +DTXSID5046649 Vd NA 0.5191 L/kg 1compartment NA NA Rat Human +DTXSID5046649 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5046649 TK.Half.Life NA 2.638 hours 1compartment NA NA Rat Human +DTXSID5046649 Css NA 0.03494 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046649 Css NA 0.2106 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046649 Css NA 0.0258 mg/L PBTK NA 50% Rat Human +DTXSID5046649 Css NA 0.1344 mg/L PBTK NA 95% Rat Human +DTXSID5046691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046691 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046691 Vd NA 3.089 L/kg 1compartment NA NA Human Human +DTXSID5046691 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID5046691 TK.Half.Life NA 84.23 hours 1compartment NA NA Human Human +DTXSID5046691 Css NA 3.268 mg/L 3compartmentss NA 50% Human Human +DTXSID5046691 Css NA 21.6 mg/L 3compartmentss NA 95% Human Human +DTXSID5046691 Css NA 2.278 mg/L PBTK NA 50% Human Human +DTXSID5046691 Css NA 14.66 mg/L PBTK NA 95% Human Human +DTXSID5046691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046691 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046691 Vd NA 2.313 L/kg 1compartment NA NA Rat Human +DTXSID5046691 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID5046691 TK.Half.Life NA 11.86 hours 1compartment NA NA Rat Human +DTXSID5046691 Css NA 0.4262 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046691 Css NA 2.271 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046691 Css NA 0.2922 mg/L PBTK NA 50% Rat Human +DTXSID5046691 Css NA 1.534 mg/L PBTK NA 95% Rat Human +DTXSID5046693 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046693 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046693 Vd NA 2.231 L/kg 1compartment NA NA Human Human DTXSID5046693 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046693 TK.Half.Life NA 1.96 hours 1compartment NA NA Human Human -DTXSID5046693 Css NA 0.05996 mg/L 3compartmentss NA 50% Human Human -DTXSID5046693 Css NA 0.4705 mg/L 3compartmentss NA 95% Human Human -DTXSID5046693 Css NA 0.04612 mg/L PBTK NA 50% Human Human -DTXSID5046693 Css NA 0.3303 mg/L PBTK NA 95% Human Human -DTXSID5046693 Clint NA 47.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046693 Fup NA 0.1643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046693 Vd NA 1.564 L/kg 1compartment NA NA Rat Human +DTXSID5046693 TK.Half.Life NA 6.217 hours 1compartment NA NA Human Human +DTXSID5046693 Css NA 0.2188 mg/L 3compartmentss NA 50% Human Human +DTXSID5046693 Css NA 1.405 mg/L 3compartmentss NA 95% Human Human +DTXSID5046693 Css NA 0.1927 mg/L PBTK NA 50% Human Human +DTXSID5046693 Css NA 1.063 mg/L PBTK NA 95% Human Human +DTXSID5046693 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046693 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046693 Vd NA 2.119 L/kg 1compartment NA NA Rat Human DTXSID5046693 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046693 TK.Half.Life NA 0.9644 hours 1compartment NA NA Rat Human -DTXSID5046693 Css NA 0.03265 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046693 Css NA 0.1977 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046693 Css NA 0.0243 mg/L PBTK NA 50% Rat Human -DTXSID5046693 Css NA 0.1296 mg/L PBTK NA 95% Rat Human -DTXSID5046695 Clint NA 6.138 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046695 Fup NA 0.4708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046695 Vd NA 2.786 L/kg 1compartment NA NA Human Human +DTXSID5046693 TK.Half.Life NA 3.237 hours 1compartment NA NA Rat Human +DTXSID5046693 Css NA 0.02536 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046693 Css NA 0.1223 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046693 Css NA 0.02271 mg/L PBTK NA 50% Rat Human +DTXSID5046693 Css NA 0.09078 mg/L PBTK NA 95% Rat Human +DTXSID5046695 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046695 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046695 Vd NA 0.8823 L/kg 1compartment NA NA Human Human DTXSID5046695 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046695 TK.Half.Life NA 13.15 hours 1compartment NA NA Human Human -DTXSID5046695 Css NA 0.4744 mg/L 3compartmentss NA 50% Human Human -DTXSID5046695 Css NA 2.531 mg/L 3compartmentss NA 95% Human Human -DTXSID5046695 Css NA 0.3667 mg/L PBTK NA 50% Human Human -DTXSID5046695 Css NA 1.812 mg/L PBTK NA 95% Human Human -DTXSID5046695 Clint NA 6.138 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046695 Fup NA 0.4708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046695 Vd NA 2.145 L/kg 1compartment NA NA Rat Human +DTXSID5046695 TK.Half.Life NA 2.05 hours 1compartment NA NA Human Human +DTXSID5046695 Css NA 0.1541 mg/L 3compartmentss NA 50% Human Human +DTXSID5046695 Css NA 1.074 mg/L 3compartmentss NA 95% Human Human +DTXSID5046695 Css NA 0.1314 mg/L PBTK NA 50% Human Human +DTXSID5046695 Css NA 0.7833 mg/L PBTK NA 95% Human Human +DTXSID5046695 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046695 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046695 Vd NA 0.8784 L/kg 1compartment NA NA Rat Human DTXSID5046695 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046695 TK.Half.Life NA 2.92 hours 1compartment NA NA Rat Human -DTXSID5046695 Css NA 0.2419 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046695 Css NA 0.9377 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046695 Css NA 0.18 mg/L PBTK NA 50% Rat Human -DTXSID5046695 Css NA 0.6436 mg/L PBTK NA 95% Rat Human -DTXSID5046697 Clint NA 3.896 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5046695 TK.Half.Life NA 1.181 hours 1compartment NA NA Rat Human +DTXSID5046695 Css NA 0.006624 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046695 Css NA 0.05356 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046695 Css NA 0.005806 mg/L PBTK NA 50% Rat Human +DTXSID5046695 Css NA 0.03881 mg/L PBTK NA 95% Rat Human +DTXSID5046697 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5046697 Fup 0.79 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5046697 Vd NA 1.653 L/kg 1compartment NA NA Human Human +DTXSID5046697 Vd NA 1.144 L/kg 1compartment NA NA Human Human DTXSID5046697 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046697 TK.Half.Life NA 2.818 hours 1compartment NA NA Human Human -DTXSID5046697 Css NA 0.1394 mg/L 3compartmentss NA 50% Human Human -DTXSID5046697 Css NA 1.061 mg/L 3compartmentss NA 95% Human Human -DTXSID5046697 Css NA 0.1269 mg/L PBTK NA 50% Human Human -DTXSID5046697 Css NA 0.7744 mg/L PBTK NA 95% Human Human -DTXSID5046697 Clint NA 3.896 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5046697 TK.Half.Life NA 1.39 hours 1compartment NA NA Human Human +DTXSID5046697 Css NA 0.04106 mg/L 3compartmentss NA 50% Human Human +DTXSID5046697 Css NA 0.4104 mg/L 3compartmentss NA 95% Human Human +DTXSID5046697 Css NA 0.03558 mg/L PBTK NA 50% Human Human +DTXSID5046697 Css NA 0.2965 mg/L PBTK NA 95% Human Human +DTXSID5046697 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5046697 Fup 0.79 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5046697 Vd NA 1.442 L/kg 1compartment NA NA Rat Human +DTXSID5046697 Vd NA 1.079 L/kg 1compartment NA NA Rat Human DTXSID5046697 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046697 TK.Half.Life NA 1.194 hours 1compartment NA NA Rat Human -DTXSID5046697 Css NA 0.06306 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046697 Css NA 0.4561 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046697 Css NA 0.05717 mg/L PBTK NA 50% Rat Human -DTXSID5046697 Css NA 0.2948 mg/L PBTK NA 95% Rat Human -DTXSID5046699 Clint NA 44.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046699 Fup NA 0.4379 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046699 Vd NA 2.765 L/kg 1compartment NA NA Human Human +DTXSID5046697 TK.Half.Life NA 0.6829 hours 1compartment NA NA Rat Human +DTXSID5046697 Css NA 0.0003523 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046697 Css NA 0.003514 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046697 Css NA 0.0003068 mg/L PBTK NA 50% Rat Human +DTXSID5046697 Css NA 0.002363 mg/L PBTK NA 95% Rat Human +DTXSID5046699 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046699 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046699 Vd NA 1.405 L/kg 1compartment NA NA Human Human DTXSID5046699 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046699 TK.Half.Life NA 1.793 hours 1compartment NA NA Human Human -DTXSID5046699 Css NA 0.01551 mg/L 3compartmentss NA 50% Human Human -DTXSID5046699 Css NA 0.1456 mg/L 3compartmentss NA 95% Human Human -DTXSID5046699 Css NA 0.0173 mg/L PBTK NA 50% Human Human -DTXSID5046699 Css NA 0.128 mg/L PBTK NA 95% Human Human -DTXSID5046699 Clint NA 44.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046699 Fup NA 0.4379 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046699 Vd NA 2.785 L/kg 1compartment NA NA Rat Human +DTXSID5046699 TK.Half.Life NA 2.412 hours 1compartment NA NA Human Human +DTXSID5046699 Css NA 0.1216 mg/L 3compartmentss NA 50% Human Human +DTXSID5046699 Css NA 0.8994 mg/L 3compartmentss NA 95% Human Human +DTXSID5046699 Css NA 0.1066 mg/L PBTK NA 50% Human Human +DTXSID5046699 Css NA 0.6537 mg/L PBTK NA 95% Human Human +DTXSID5046699 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046699 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046699 Vd NA 1.411 L/kg 1compartment NA NA Rat Human DTXSID5046699 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046699 TK.Half.Life NA 0.9063 hours 1compartment NA NA Rat Human -DTXSID5046699 Css NA 0.008052 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046699 Css NA 0.06446 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046699 Css NA 0.008924 mg/L PBTK NA 50% Rat Human -DTXSID5046699 Css NA 0.05498 mg/L PBTK NA 95% Rat Human +DTXSID5046699 TK.Half.Life NA 1.359 hours 1compartment NA NA Rat Human +DTXSID5046699 Css NA 0.01355 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046699 Css NA 0.08299 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046699 Css NA 0.01212 mg/L PBTK NA 50% Rat Human +DTXSID5046699 Css NA 0.05707 mg/L PBTK NA 95% Rat Human DTXSID5046720 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5046720 Fup NA 0.0812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046720 Vd NA 28.91 L/kg 1compartment NA NA Human Human -DTXSID5046720 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID5046720 TK.Half.Life NA 1349000 hours 1compartment NA NA Human Human -DTXSID5046720 Css NA 1159 mg/L 3compartmentss NA 50% Human Human -DTXSID5046720 Css NA 3022 mg/L 3compartmentss NA 95% Human Human -DTXSID5046720 Css NA 3591 mg/L PBTK NA 50% Human Human -DTXSID5046720 Css NA 7754 mg/L PBTK NA 95% Human Human +DTXSID5046720 Vd NA 9.501 L/kg 1compartment NA NA Human Human +DTXSID5046720 Days.Css NA 1876 Days PBTK NA NA Human Human +DTXSID5046720 TK.Half.Life NA 6897 hours 1compartment NA NA Human Human +DTXSID5046720 Css NA 40.19 mg/L 3compartmentss NA 50% Human Human +DTXSID5046720 Css NA 141 mg/L 3compartmentss NA 95% Human Human +DTXSID5046720 Css NA 51.54 mg/L PBTK NA 50% Human Human +DTXSID5046720 Css NA 137.7 mg/L PBTK NA 95% Human Human DTXSID5046720 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5046720 Fup NA 0.0812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046720 Vd NA 23.85 L/kg 1compartment NA NA Rat Human -DTXSID5046720 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID5046720 TK.Half.Life NA 90790 hours 1compartment NA NA Rat Human -DTXSID5046720 Css NA 289.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046720 Css NA 524.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046720 Css NA 954.9 mg/L PBTK NA 50% Rat Human -DTXSID5046720 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID5046722 Clint NA 1.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046722 Fup NA 0.0638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046722 Vd NA 0.2217 L/kg 1compartment NA NA Human Human +DTXSID5046720 Vd NA 7.726 L/kg 1compartment NA NA Rat Human +DTXSID5046720 Days.Css NA 518 Days PBTK NA NA Rat Human +DTXSID5046720 TK.Half.Life NA 615.6 hours 1compartment NA NA Rat Human +DTXSID5046720 Css NA 0.9232 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046720 Css NA 4.592 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046720 Css NA 1.21 mg/L PBTK NA 50% Rat Human +DTXSID5046720 Css NA 4.849 mg/L PBTK NA 95% Rat Human +DTXSID5046722 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046722 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046722 Vd NA 0.3338 L/kg 1compartment NA NA Human Human DTXSID5046722 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046722 TK.Half.Life NA 8.231 hours 1compartment NA NA Human Human -DTXSID5046722 Css NA 6.314 mg/L 3compartmentss NA 50% Human Human -DTXSID5046722 Css NA 31.59 mg/L 3compartmentss NA 95% Human Human -DTXSID5046722 Css NA 3.757 mg/L PBTK NA 50% Human Human -DTXSID5046722 Css NA 18.47 mg/L PBTK NA 95% Human Human -DTXSID5046722 Clint NA 1.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046722 Fup NA 0.0638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046722 Vd NA 0.2199 L/kg 1compartment NA NA Rat Human +DTXSID5046722 TK.Half.Life NA 1.38 hours 1compartment NA NA Human Human +DTXSID5046722 Css NA 0.2484 mg/L 3compartmentss NA 50% Human Human +DTXSID5046722 Css NA 1.664 mg/L 3compartmentss NA 95% Human Human +DTXSID5046722 Css NA 0.1607 mg/L PBTK NA 50% Human Human +DTXSID5046722 Css NA 1.037 mg/L PBTK NA 95% Human Human +DTXSID5046722 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046722 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046722 Vd NA 0.3304 L/kg 1compartment NA NA Rat Human DTXSID5046722 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046722 TK.Half.Life NA 4.119 hours 1compartment NA NA Rat Human -DTXSID5046722 Css NA 2.651 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046722 Css NA 10.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046722 Css NA 1.484 mg/L PBTK NA 50% Rat Human -DTXSID5046722 Css NA 5.762 mg/L PBTK NA 95% Rat Human -DTXSID5046724 Clint NA 39.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046724 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046724 Vd NA 3.021 L/kg 1compartment NA NA Human Human -DTXSID5046724 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID5046724 TK.Half.Life NA 50.67 hours 1compartment NA NA Human Human -DTXSID5046724 Css NA 2.058 mg/L 3compartmentss NA 50% Human Human -DTXSID5046724 Css NA 12.44 mg/L 3compartmentss NA 95% Human Human -DTXSID5046724 Css NA 1.414 mg/L PBTK NA 50% Human Human -DTXSID5046724 Css NA 8.369 mg/L PBTK NA 95% Human Human -DTXSID5046724 Clint NA 39.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046724 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046724 Vd NA 2.265 L/kg 1compartment NA NA Rat Human -DTXSID5046724 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5046724 TK.Half.Life NA 8.035 hours 1compartment NA NA Rat Human -DTXSID5046724 Css NA 1.168 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046724 Css NA 5.676 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046724 Css NA 0.7646 mg/L PBTK NA 50% Rat Human -DTXSID5046724 Css NA 3.728 mg/L PBTK NA 95% Rat Human -DTXSID5046726 Clint NA 16.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046726 Fup NA 0.0548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046726 Vd NA 3.143 L/kg 1compartment NA NA Human Human +DTXSID5046722 TK.Half.Life NA 0.8113 hours 1compartment NA NA Rat Human +DTXSID5046722 Css NA 0.002456 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046722 Css NA 0.01409 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046722 Css NA 0.001494 mg/L PBTK NA 50% Rat Human +DTXSID5046722 Css NA 0.008184 mg/L PBTK NA 95% Rat Human +DTXSID5046724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046724 Fup 0.0186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046724 Vd NA 6.859 L/kg 1compartment NA NA Human Human +DTXSID5046724 Days.Css NA 37 Days PBTK NA NA Human Human +DTXSID5046724 TK.Half.Life NA 193.3 hours 1compartment NA NA Human Human +DTXSID5046724 Css NA 2.49 mg/L 3compartmentss NA 50% Human Human +DTXSID5046724 Css NA 16.19 mg/L 3compartmentss NA 95% Human Human +DTXSID5046724 Css NA 2.338 mg/L PBTK NA 50% Human Human +DTXSID5046724 Css NA 14.18 mg/L PBTK NA 95% Human Human +DTXSID5046724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046724 Fup 0.0186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046724 Vd NA 5.316 L/kg 1compartment NA NA Rat Human +DTXSID5046724 Days.Css NA 22 Days PBTK NA NA Rat Human +DTXSID5046724 TK.Half.Life NA 26.96 hours 1compartment NA NA Rat Human +DTXSID5046724 Css NA 0.3134 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046724 Css NA 1.637 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046724 Css NA 0.3005 mg/L PBTK NA 50% Rat Human +DTXSID5046724 Css NA 1.532 mg/L PBTK NA 95% Rat Human +DTXSID5046726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046726 Fup 0.0639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046726 Vd NA 3.208 L/kg 1compartment NA NA Human Human DTXSID5046726 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5046726 TK.Half.Life NA 17.8 hours 1compartment NA NA Human Human -DTXSID5046726 Css NA 0.6298 mg/L 3compartmentss NA 50% Human Human -DTXSID5046726 Css NA 4.156 mg/L 3compartmentss NA 95% Human Human -DTXSID5046726 Css NA 0.4593 mg/L PBTK NA 50% Human Human -DTXSID5046726 Css NA 2.883 mg/L PBTK NA 95% Human Human -DTXSID5046726 Clint NA 16.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046726 Fup NA 0.0548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046726 Vd NA 2.464 L/kg 1compartment NA NA Rat Human +DTXSID5046726 TK.Half.Life NA 16.4 hours 1compartment NA NA Human Human +DTXSID5046726 Css NA 0.5175 mg/L 3compartmentss NA 50% Human Human +DTXSID5046726 Css NA 3.459 mg/L 3compartmentss NA 95% Human Human +DTXSID5046726 Css NA 0.372 mg/L PBTK NA 50% Human Human +DTXSID5046726 Css NA 2.393 mg/L PBTK NA 95% Human Human +DTXSID5046726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046726 Fup 0.0639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046726 Vd NA 2.474 L/kg 1compartment NA NA Rat Human DTXSID5046726 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046726 TK.Half.Life NA 3.8 hours 1compartment NA NA Rat Human -DTXSID5046726 Css NA 0.3478 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046726 Css NA 1.953 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046726 Css NA 0.2424 mg/L PBTK NA 50% Rat Human -DTXSID5046726 Css NA 1.309 mg/L PBTK NA 95% Rat Human -DTXSID5046728 Clint NA 1.335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046728 Fup NA 0.0463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046728 Vd NA 0.2912 L/kg 1compartment NA NA Human Human -DTXSID5046728 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5046728 TK.Half.Life NA 12.7 hours 1compartment NA NA Human Human -DTXSID5046728 Css NA 7.424 mg/L 3compartmentss NA 50% Human Human -DTXSID5046728 Css NA 40.77 mg/L 3compartmentss NA 95% Human Human -DTXSID5046728 Css NA 4.505 mg/L PBTK NA 50% Human Human -DTXSID5046728 Css NA 23.99 mg/L PBTK NA 95% Human Human -DTXSID5046728 Clint NA 1.335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046728 Fup NA 0.0463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046728 Vd NA 0.2722 L/kg 1compartment NA NA Rat Human +DTXSID5046726 TK.Half.Life NA 3.007 hours 1compartment NA NA Rat Human +DTXSID5046726 Css NA 0.06672 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046726 Css NA 0.4009 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046726 Css NA 0.04795 mg/L PBTK NA 50% Rat Human +DTXSID5046726 Css NA 0.2778 mg/L PBTK NA 95% Rat Human +DTXSID5046728 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046728 Fup 0.088 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046728 Vd NA 0.3596 L/kg 1compartment NA NA Human Human +DTXSID5046728 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046728 TK.Half.Life NA 1.012 hours 1compartment NA NA Human Human +DTXSID5046728 Css NA 0.3236 mg/L 3compartmentss NA 50% Human Human +DTXSID5046728 Css NA 2.568 mg/L 3compartmentss NA 95% Human Human +DTXSID5046728 Css NA 0.2042 mg/L PBTK NA 50% Human Human +DTXSID5046728 Css NA 1.535 mg/L PBTK NA 95% Human Human +DTXSID5046728 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046728 Fup 0.088 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046728 Vd NA 0.3382 L/kg 1compartment NA NA Rat Human DTXSID5046728 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046728 TK.Half.Life NA 6.233 hours 1compartment NA NA Rat Human -DTXSID5046728 Css NA 3.291 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046728 Css NA 13.39 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046728 Css NA 1.87 mg/L PBTK NA 50% Rat Human -DTXSID5046728 Css NA 7.355 mg/L PBTK NA 95% Rat Human -DTXSID5046770 Clint NA 20.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046770 Fup NA 0.2302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046770 Vd NA 0.3665 L/kg 1compartment NA NA Human Human +DTXSID5046728 TK.Half.Life NA 0.5719 hours 1compartment NA NA Rat Human +DTXSID5046728 Css NA 0.0424 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046728 Css NA 0.267 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046728 Css NA 0.02595 mg/L PBTK NA 50% Rat Human +DTXSID5046728 Css NA 0.1565 mg/L PBTK NA 95% Rat Human +DTXSID5046770 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046770 Fup 0.44 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046770 Vd NA 0.5089 L/kg 1compartment NA NA Human Human DTXSID5046770 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046770 TK.Half.Life NA 0.5889 hours 1compartment NA NA Human Human -DTXSID5046770 Css NA 0.1083 mg/L 3compartmentss NA 50% Human Human -DTXSID5046770 Css NA 0.7273 mg/L 3compartmentss NA 95% Human Human -DTXSID5046770 Css NA 0.07059 mg/L PBTK NA 50% Human Human -DTXSID5046770 Css NA 0.4474 mg/L PBTK NA 95% Human Human -DTXSID5046770 Clint NA 20.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046770 Fup NA 0.2302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046770 Vd NA 0.3613 L/kg 1compartment NA NA Rat Human +DTXSID5046770 TK.Half.Life NA 0.9787 hours 1compartment NA NA Human Human +DTXSID5046770 Css NA 0.1559 mg/L 3compartmentss NA 50% Human Human +DTXSID5046770 Css NA 1.053 mg/L 3compartmentss NA 95% Human Human +DTXSID5046770 Css NA 0.111 mg/L PBTK NA 50% Human Human +DTXSID5046770 Css NA 0.6863 mg/L PBTK NA 95% Human Human +DTXSID5046770 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046770 Fup 0.44 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046770 Vd NA 0.5034 L/kg 1compartment NA NA Rat Human DTXSID5046770 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046770 TK.Half.Life NA 0.3169 hours 1compartment NA NA Rat Human -DTXSID5046770 Css NA 0.0594 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046770 Css NA 0.2983 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046770 Css NA 0.03674 mg/L PBTK NA 50% Rat Human -DTXSID5046770 Css NA 0.1777 mg/L PBTK NA 95% Rat Human -DTXSID5046772 Clint NA 40.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5046770 TK.Half.Life NA 0.5328 hours 1compartment NA NA Rat Human +DTXSID5046770 Css NA 0.01806 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046770 Css NA 0.09226 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046770 Css NA 0.01279 mg/L PBTK NA 50% Rat Human +DTXSID5046770 Css NA 0.05769 mg/L PBTK NA 95% Rat Human +DTXSID5046772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5046772 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID5046772 Vd NA 3.077 L/kg 1compartment NA NA Human Human -DTXSID5046772 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5046772 TK.Half.Life NA 26.81 hours 1compartment NA NA Human Human -DTXSID5046772 Css NA 0.994 mg/L 3compartmentss NA 50% Human Human -DTXSID5046772 Css NA 6.489 mg/L 3compartmentss NA 95% Human Human -DTXSID5046772 Css NA 0.6908 mg/L PBTK NA 50% Human Human -DTXSID5046772 Css NA 4.461 mg/L PBTK NA 95% Human Human -DTXSID5046772 Clint NA 40.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5046772 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID5046772 TK.Half.Life NA 47.54 hours 1compartment NA NA Human Human +DTXSID5046772 Css NA 1.797 mg/L 3compartmentss NA 50% Human Human +DTXSID5046772 Css NA 11.82 mg/L 3compartmentss NA 95% Human Human +DTXSID5046772 Css NA 1.248 mg/L PBTK NA 50% Human Human +DTXSID5046772 Css NA 7.932 mg/L PBTK NA 95% Human Human +DTXSID5046772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5046772 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID5046772 Vd NA 2.308 L/kg 1compartment NA NA Rat Human -DTXSID5046772 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5046772 TK.Half.Life NA 4.193 hours 1compartment NA NA Rat Human -DTXSID5046772 Css NA 0.5637 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046772 Css NA 3.006 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046772 Css NA 0.3752 mg/L PBTK NA 50% Rat Human -DTXSID5046772 Css NA 1.961 mg/L PBTK NA 95% Rat Human -DTXSID5046776 Clint NA 2.036 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046776 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046776 Vd NA 0.1835 L/kg 1compartment NA NA Human Human -DTXSID5046776 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5046776 TK.Half.Life NA 32.6 hours 1compartment NA NA Human Human -DTXSID5046776 Css NA 32.06 mg/L 3compartmentss NA 50% Human Human -DTXSID5046776 Css NA 236.2 mg/L 3compartmentss NA 95% Human Human -DTXSID5046776 Css NA 18.72 mg/L PBTK NA 50% Human Human -DTXSID5046776 Css NA 139.4 mg/L PBTK NA 95% Human Human -DTXSID5046776 Clint NA 2.036 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046776 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046776 Vd NA 0.1782 L/kg 1compartment NA NA Rat Human -DTXSID5046776 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5046776 TK.Half.Life NA 17.89 hours 1compartment NA NA Rat Human -DTXSID5046776 Css NA 15.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046776 Css NA 91.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046776 Css NA 8.369 mg/L PBTK NA 50% Rat Human -DTXSID5046776 Css NA 49.28 mg/L PBTK NA 95% Rat Human -DTXSID5046778 Clint NA 15.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046778 Fup NA 0.0263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046778 Vd NA 1.224 L/kg 1compartment NA NA Human Human -DTXSID5046778 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5046778 TK.Half.Life NA 11.94 hours 1compartment NA NA Human Human -DTXSID5046778 Css NA 1.57 mg/L 3compartmentss NA 50% Human Human -DTXSID5046778 Css NA 14.26 mg/L 3compartmentss NA 95% Human Human -DTXSID5046778 Css NA 0.9805 mg/L PBTK NA 50% Human Human -DTXSID5046778 Css NA 8.295 mg/L PBTK NA 95% Human Human -DTXSID5046778 Clint NA 15.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046778 Fup NA 0.0263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046778 Vd NA 0.9129 L/kg 1compartment NA NA Rat Human -DTXSID5046778 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046778 TK.Half.Life NA 4.958 hours 1compartment NA NA Rat Human -DTXSID5046778 Css NA 0.894 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046778 Css NA 6.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046778 Css NA 0.5198 mg/L PBTK NA 50% Rat Human -DTXSID5046778 Css NA 3.452 mg/L PBTK NA 95% Rat Human -DTXSID5046801 Clint NA 40.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046801 Fup NA 0.0238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046801 Vd NA 1.402 L/kg 1compartment NA NA Human Human -DTXSID5046801 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046801 TK.Half.Life NA 6.646 hours 1compartment NA NA Human Human -DTXSID5046801 Css NA 0.6895 mg/L 3compartmentss NA 50% Human Human -DTXSID5046801 Css NA 6.17 mg/L 3compartmentss NA 95% Human Human -DTXSID5046801 Css NA 0.4317 mg/L PBTK NA 50% Human Human -DTXSID5046801 Css NA 3.791 mg/L PBTK NA 95% Human Human -DTXSID5046801 Clint NA 40.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046801 Fup NA 0.0238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046801 Vd NA 1.043 L/kg 1compartment NA NA Rat Human +DTXSID5046772 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5046772 TK.Half.Life NA 7.044 hours 1compartment NA NA Rat Human +DTXSID5046772 Css NA 0.2322 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046772 Css NA 1.27 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046772 Css NA 0.1594 mg/L PBTK NA 50% Rat Human +DTXSID5046772 Css NA 0.8424 mg/L PBTK NA 95% Rat Human +DTXSID5046776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046776 Fup 0.0376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046776 Vd NA 0.2482 L/kg 1compartment NA NA Human Human +DTXSID5046776 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046776 TK.Half.Life NA 1.371 hours 1compartment NA NA Human Human +DTXSID5046776 Css NA 0.8524 mg/L 3compartmentss NA 50% Human Human +DTXSID5046776 Css NA 7.884 mg/L 3compartmentss NA 95% Human Human +DTXSID5046776 Css NA 0.5135 mg/L PBTK NA 50% Human Human +DTXSID5046776 Css NA 4.688 mg/L PBTK NA 95% Human Human +DTXSID5046776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046776 Fup 0.0376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046776 Vd NA 0.2378 L/kg 1compartment NA NA Rat Human +DTXSID5046776 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5046776 TK.Half.Life NA 0.8389 hours 1compartment NA NA Rat Human +DTXSID5046776 Css NA 0.1142 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046776 Css NA 0.818 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046776 Css NA 0.06611 mg/L PBTK NA 50% Rat Human +DTXSID5046776 Css NA 0.4655 mg/L PBTK NA 95% Rat Human +DTXSID5046778 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046778 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046778 Vd NA 2.833 L/kg 1compartment NA NA Human Human +DTXSID5046778 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID5046778 TK.Half.Life NA 46 hours 1compartment NA NA Human Human +DTXSID5046778 Css NA 1.744 mg/L 3compartmentss NA 50% Human Human +DTXSID5046778 Css NA 9.361 mg/L 3compartmentss NA 95% Human Human +DTXSID5046778 Css NA 1.217 mg/L PBTK NA 50% Human Human +DTXSID5046778 Css NA 6.373 mg/L PBTK NA 95% Human Human +DTXSID5046778 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046778 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046778 Vd NA 2.132 L/kg 1compartment NA NA Rat Human +DTXSID5046778 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5046778 TK.Half.Life NA 8.543 hours 1compartment NA NA Rat Human +DTXSID5046778 Css NA 0.08224 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046778 Css NA 0.4913 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046778 Css NA 0.05639 mg/L PBTK NA 50% Rat Human +DTXSID5046778 Css NA 0.3193 mg/L PBTK NA 95% Rat Human +DTXSID5046801 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID5046801 Fup 0.023 NA NA Williamson 2020 NA Human Human +DTXSID5046801 Vd NA 0.4121 L/kg 1compartment NA NA Human Human +DTXSID5046801 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5046801 TK.Half.Life NA 10.38 hours 1compartment NA NA Human Human +DTXSID5046801 Css NA 4.401 mg/L 3compartmentss NA 50% Human Human +DTXSID5046801 Css NA 38.02 mg/L 3compartmentss NA 95% Human Human +DTXSID5046801 Css NA 2.619 mg/L PBTK NA 50% Human Human +DTXSID5046801 Css NA 22.16 mg/L PBTK NA 95% Human Human +DTXSID5046801 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID5046801 Fup 0.023 NA NA Williamson 2020 NA Rat Human +DTXSID5046801 Vd NA 0.3343 L/kg 1compartment NA NA Rat Human DTXSID5046801 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046801 TK.Half.Life NA 2.614 hours 1compartment NA NA Rat Human -DTXSID5046801 Css NA 0.3845 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046801 Css NA 2.901 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046801 Css NA 0.2246 mg/L PBTK NA 50% Rat Human -DTXSID5046801 Css NA 1.617 mg/L PBTK NA 95% Rat Human -DTXSID5046803 Clint NA 2.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046803 Fup NA 0.2442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046803 Vd NA 0.3414 L/kg 1compartment NA NA Human Human +DTXSID5046801 TK.Half.Life NA 5.263 hours 1compartment NA NA Rat Human +DTXSID5046801 Css NA 0.5534 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046801 Css NA 3.659 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046801 Css NA 0.3174 mg/L PBTK NA 50% Rat Human +DTXSID5046801 Css NA 2.064 mg/L PBTK NA 95% Rat Human +DTXSID5046803 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046803 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046803 Vd NA 0.386 L/kg 1compartment NA NA Human Human DTXSID5046803 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046803 TK.Half.Life NA 2.063 hours 1compartment NA NA Human Human -DTXSID5046803 Css NA 0.7158 mg/L 3compartmentss NA 50% Human Human -DTXSID5046803 Css NA 3.476 mg/L 3compartmentss NA 95% Human Human -DTXSID5046803 Css NA 0.4665 mg/L PBTK NA 50% Human Human -DTXSID5046803 Css NA 2.142 mg/L PBTK NA 95% Human Human -DTXSID5046803 Clint NA 2.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046803 Fup NA 0.2442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046803 Vd NA 0.3419 L/kg 1compartment NA NA Rat Human +DTXSID5046803 TK.Half.Life NA 1.073 hours 1compartment NA NA Human Human +DTXSID5046803 Css NA 0.2624 mg/L 3compartmentss NA 50% Human Human +DTXSID5046803 Css NA 1.566 mg/L 3compartmentss NA 95% Human Human +DTXSID5046803 Css NA 0.1748 mg/L PBTK NA 50% Human Human +DTXSID5046803 Css NA 0.9819 mg/L PBTK NA 95% Human Human +DTXSID5046803 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046803 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046803 Vd NA 0.3815 L/kg 1compartment NA NA Rat Human DTXSID5046803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046803 TK.Half.Life NA 1.137 hours 1compartment NA NA Rat Human -DTXSID5046803 Css NA 0.3304 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046803 Css NA 1.197 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046803 Css NA 0.2042 mg/L PBTK NA 50% Rat Human -DTXSID5046803 Css NA 0.6885 mg/L PBTK NA 95% Rat Human -DTXSID5046805 Clint NA 18.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046805 Fup NA 0.1334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046805 Vd NA 1.938 L/kg 1compartment NA NA Human Human +DTXSID5046803 TK.Half.Life NA 0.6075 hours 1compartment NA NA Rat Human +DTXSID5046803 Css NA 0.03155 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046803 Css NA 0.1389 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046803 Css NA 0.02056 mg/L PBTK NA 50% Rat Human +DTXSID5046803 Css NA 0.08505 mg/L PBTK NA 95% Rat Human +DTXSID5046805 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046805 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046805 Vd NA 1.846 L/kg 1compartment NA NA Human Human DTXSID5046805 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046805 TK.Half.Life NA 3.864 hours 1compartment NA NA Human Human -DTXSID5046805 Css NA 0.1738 mg/L 3compartmentss NA 50% Human Human -DTXSID5046805 Css NA 1.554 mg/L 3compartmentss NA 95% Human Human -DTXSID5046805 Css NA 0.1388 mg/L PBTK NA 50% Human Human -DTXSID5046805 Css NA 1.054 mg/L PBTK NA 95% Human Human -DTXSID5046805 Clint NA 18.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046805 Fup NA 0.1334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046805 Vd NA 1.914 L/kg 1compartment NA NA Rat Human +DTXSID5046805 TK.Half.Life NA 3.761 hours 1compartment NA NA Human Human +DTXSID5046805 Css NA 0.1788 mg/L 3compartmentss NA 50% Human Human +DTXSID5046805 Css NA 1.61 mg/L 3compartmentss NA 95% Human Human +DTXSID5046805 Css NA 0.1395 mg/L PBTK NA 50% Human Human +DTXSID5046805 Css NA 1.098 mg/L PBTK NA 95% Human Human +DTXSID5046805 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046805 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046805 Vd NA 1.811 L/kg 1compartment NA NA Rat Human DTXSID5046805 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046805 TK.Half.Life NA 2.232 hours 1compartment NA NA Rat Human -DTXSID5046805 Css NA 0.09652 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046805 Css NA 0.6455 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046805 Css NA 0.07389 mg/L PBTK NA 50% Rat Human -DTXSID5046805 Css NA 0.4163 mg/L PBTK NA 95% Rat Human -DTXSID5046807 Clint NA 21.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046807 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046807 Vd NA 5895 L/kg 1compartment NA NA Human Human +DTXSID5046805 TK.Half.Life NA 2.159 hours 1compartment NA NA Rat Human +DTXSID5046805 Css NA 0.02298 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046805 Css NA 0.1683 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046805 Css NA 0.01758 mg/L PBTK NA 50% Rat Human +DTXSID5046805 Css NA 0.1076 mg/L PBTK NA 95% Rat Human +DTXSID5046807 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046807 Fup 0.0154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046807 Vd NA 73.37 L/kg 1compartment NA NA Human Human DTXSID5046807 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID5046807 TK.Half.Life NA 178400 hours 1compartment NA NA Human Human -DTXSID5046807 Css NA 0.002387 mg/L 3compartmentss NA 50% Human Human -DTXSID5046807 Css NA 0.01402 mg/L 3compartmentss NA 95% Human Human -DTXSID5046807 Css NA 2.54 mg/L PBTK NA 50% Human Human -DTXSID5046807 Css NA 13.98 mg/L PBTK NA 95% Human Human -DTXSID5046807 Clint NA 21.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046807 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046807 Vd NA 5523 L/kg 1compartment NA NA Rat Human -DTXSID5046807 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID5046807 TK.Half.Life NA 30720 hours 1compartment NA NA Rat Human -DTXSID5046807 Css NA 0.001208 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046807 Css NA 0.005132 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046807 Css NA 1.364 mg/L PBTK NA 50% Rat Human -DTXSID5046807 Css NA 5.901 mg/L PBTK NA 95% Rat Human -DTXSID5046851 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046851 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046851 Vd NA 0.4548 L/kg 1compartment NA NA Human Human -DTXSID5046851 Days.Css NA 231 Days PBTK NA NA Human Human -DTXSID5046851 TK.Half.Life NA 870.6 hours 1compartment NA NA Human Human -DTXSID5046851 Css NA 333.4 mg/L 3compartmentss NA 50% Human Human -DTXSID5046851 Css NA 1564 mg/L 3compartmentss NA 95% Human Human -DTXSID5046851 Css NA 195.8 mg/L PBTK NA 50% Human Human -DTXSID5046851 Css NA 901.2 mg/L PBTK NA 95% Human Human -DTXSID5046851 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046851 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046851 Vd NA 0.3465 L/kg 1compartment NA NA Rat Human -DTXSID5046851 Days.Css NA 54 Days PBTK NA NA Rat Human -DTXSID5046851 TK.Half.Life NA 220.1 hours 1compartment NA NA Rat Human -DTXSID5046851 Css NA 94.75 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046851 Css NA 377.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046851 Css NA 51.89 mg/L PBTK NA 50% Rat Human -DTXSID5046851 Css NA 204.8 mg/L PBTK NA 95% Rat Human -DTXSID5046853 Clint NA 13.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046853 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046853 Vd NA 0.5005 L/kg 1compartment NA NA Human Human -DTXSID5046853 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5046853 TK.Half.Life NA 30.45 hours 1compartment NA NA Human Human -DTXSID5046853 Css NA 11.63 mg/L 3compartmentss NA 50% Human Human -DTXSID5046853 Css NA 90.04 mg/L 3compartmentss NA 95% Human Human -DTXSID5046853 Css NA 6.792 mg/L PBTK NA 50% Human Human -DTXSID5046853 Css NA 52.27 mg/L PBTK NA 95% Human Human -DTXSID5046853 Clint NA 13.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046853 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046853 Vd NA 0.3756 L/kg 1compartment NA NA Rat Human -DTXSID5046853 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5046853 TK.Half.Life NA 14.94 hours 1compartment NA NA Rat Human -DTXSID5046853 Css NA 6.536 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046853 Css NA 38.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046853 Css NA 3.575 mg/L PBTK NA 50% Rat Human -DTXSID5046853 Css NA 21.05 mg/L PBTK NA 95% Rat Human -DTXSID5046855 Clint NA 3976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046855 Fup NA 0.2105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046855 Vd NA 2.154 L/kg 1compartment NA NA Human Human +DTXSID5046807 TK.Half.Life NA 3501000 hours 1compartment NA NA Human Human +DTXSID5046807 Css NA 419 mg/L 3compartmentss NA 50% Human Human +DTXSID5046807 Css NA 1099 mg/L 3compartmentss NA 95% Human Human +DTXSID5046807 Css NA 3589 mg/L PBTK NA 50% Human Human +DTXSID5046807 Css NA 7701 mg/L PBTK NA 95% Human Human +DTXSID5046807 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046807 Fup 0.0154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046807 Vd NA 62.74 L/kg 1compartment NA NA Rat Human +DTXSID5046807 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID5046807 TK.Half.Life NA 249600 hours 1compartment NA NA Rat Human +DTXSID5046807 Css NA 23.66 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046807 Css NA 42.5 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046807 Css NA 229.3 mg/L PBTK NA 50% Rat Human +DTXSID5046807 Css NA 311.1 mg/L PBTK NA 95% Rat Human +DTXSID5046851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046851 Fup 0.00973 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046851 Vd NA 1.501 L/kg 1compartment NA NA Human Human +DTXSID5046851 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5046851 TK.Half.Life NA 22.89 hours 1compartment NA NA Human Human +DTXSID5046851 Css NA 2.472 mg/L 3compartmentss NA 50% Human Human +DTXSID5046851 Css NA 22.05 mg/L 3compartmentss NA 95% Human Human +DTXSID5046851 Css NA 1.542 mg/L PBTK NA 50% Human Human +DTXSID5046851 Css NA 13.44 mg/L PBTK NA 95% Human Human +DTXSID5046851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046851 Fup 0.00973 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046851 Vd NA 1.109 L/kg 1compartment NA NA Rat Human +DTXSID5046851 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5046851 TK.Half.Life NA 8.828 hours 1compartment NA NA Rat Human +DTXSID5046851 Css NA 0.321 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046851 Css NA 2.354 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046851 Css NA 0.1946 mg/L PBTK NA 50% Rat Human +DTXSID5046851 Css NA 1.364 mg/L PBTK NA 95% Rat Human +DTXSID5046853 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046853 Fup 0.0147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046853 Vd NA 0.2719 L/kg 1compartment NA NA Human Human +DTXSID5046853 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046853 TK.Half.Life NA 3.352 hours 1compartment NA NA Human Human +DTXSID5046853 Css NA 2.11 mg/L 3compartmentss NA 50% Human Human +DTXSID5046853 Css NA 21.55 mg/L 3compartmentss NA 95% Human Human +DTXSID5046853 Css NA 1.243 mg/L PBTK NA 50% Human Human +DTXSID5046853 Css NA 12.45 mg/L PBTK NA 95% Human Human +DTXSID5046853 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046853 Fup 0.0147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046853 Vd NA 0.2396 L/kg 1compartment NA NA Rat Human +DTXSID5046853 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5046853 TK.Half.Life NA 1.952 hours 1compartment NA NA Rat Human +DTXSID5046853 Css NA 0.2811 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046853 Css NA 2.173 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046853 Css NA 0.161 mg/L PBTK NA 50% Rat Human +DTXSID5046853 Css NA 1.233 mg/L PBTK NA 95% Rat Human +DTXSID5046855 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046855 Fup 0.288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046855 Vd NA 2.116 L/kg 1compartment NA NA Human Human DTXSID5046855 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046855 TK.Half.Life NA 1.557 hours 1compartment NA NA Human Human -DTXSID5046855 Css NA 0.0007251 mg/L 3compartmentss NA 50% Human Human -DTXSID5046855 Css NA 0.005183 mg/L 3compartmentss NA 95% Human Human -DTXSID5046855 Css NA 0.0005592 mg/L PBTK NA 50% Human Human -DTXSID5046855 Css NA 0.003707 mg/L PBTK NA 95% Human Human -DTXSID5046855 Clint NA 3976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046855 Fup NA 0.2105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046855 Vd NA 1.786 L/kg 1compartment NA NA Rat Human +DTXSID5046855 TK.Half.Life NA 3.627 hours 1compartment NA NA Human Human +DTXSID5046855 Css NA 0.09912 mg/L 3compartmentss NA 50% Human Human +DTXSID5046855 Css NA 0.6781 mg/L 3compartmentss NA 95% Human Human +DTXSID5046855 Css NA 0.0732 mg/L PBTK NA 50% Human Human +DTXSID5046855 Css NA 0.4754 mg/L PBTK NA 95% Human Human +DTXSID5046855 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046855 Fup 0.288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046855 Vd NA 1.632 L/kg 1compartment NA NA Rat Human DTXSID5046855 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046855 TK.Half.Life NA 0.5608 hours 1compartment NA NA Rat Human -DTXSID5046855 Css NA 0.0004005 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046855 Css NA 0.002437 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046855 Css NA 0.0002978 mg/L PBTK NA 50% Rat Human -DTXSID5046855 Css NA 0.001681 mg/L PBTK NA 95% Rat Human -DTXSID5046857 Clint NA 14.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046857 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046857 Vd NA 0.2114 L/kg 1compartment NA NA Human Human +DTXSID5046855 TK.Half.Life NA 1.187 hours 1compartment NA NA Rat Human +DTXSID5046855 Css NA 0.00471 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046855 Css NA 0.03618 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046855 Css NA 0.003509 mg/L PBTK NA 50% Rat Human +DTXSID5046855 Css NA 0.02434 mg/L PBTK NA 95% Rat Human +DTXSID5046857 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046857 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046857 Vd NA 0.3385 L/kg 1compartment NA NA Human Human DTXSID5046857 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046857 TK.Half.Life NA 1.768 hours 1compartment NA NA Human Human -DTXSID5046857 Css NA 1.407 mg/L 3compartmentss NA 50% Human Human -DTXSID5046857 Css NA 10.33 mg/L 3compartmentss NA 95% Human Human -DTXSID5046857 Css NA 0.8299 mg/L PBTK NA 50% Human Human -DTXSID5046857 Css NA 6.019 mg/L PBTK NA 95% Human Human -DTXSID5046857 Clint NA 14.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046857 Fup NA 0.0355 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046857 Vd NA 0.2051 L/kg 1compartment NA NA Rat Human +DTXSID5046857 TK.Half.Life NA 1.492 hours 1compartment NA NA Human Human +DTXSID5046857 Css NA 0.5412 mg/L 3compartmentss NA 50% Human Human +DTXSID5046857 Css NA 3.705 mg/L 3compartmentss NA 95% Human Human +DTXSID5046857 Css NA 0.3415 mg/L PBTK NA 50% Human Human +DTXSID5046857 Css NA 2.206 mg/L PBTK NA 95% Human Human +DTXSID5046857 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046857 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046857 Vd NA 0.328 L/kg 1compartment NA NA Rat Human DTXSID5046857 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046857 TK.Half.Life NA 1.105 hours 1compartment NA NA Rat Human -DTXSID5046857 Css NA 0.797 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046857 Css NA 4.255 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046857 Css NA 0.4383 mg/L PBTK NA 50% Rat Human -DTXSID5046857 Css NA 2.328 mg/L PBTK NA 95% Rat Human -DTXSID5046859 Clint NA 56.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046859 Fup NA 0.2989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046859 Vd NA 3.177 L/kg 1compartment NA NA Human Human +DTXSID5046857 TK.Half.Life NA 0.8605 hours 1compartment NA NA Rat Human +DTXSID5046857 Css NA 0.06618 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046857 Css NA 0.3289 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046857 Css NA 0.04062 mg/L PBTK NA 50% Rat Human +DTXSID5046857 Css NA 0.1904 mg/L PBTK NA 95% Rat Human +DTXSID5046859 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046859 Fup 0.428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046859 Vd NA 1.582 L/kg 1compartment NA NA Human Human DTXSID5046859 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046859 TK.Half.Life NA 2.097 hours 1compartment NA NA Human Human -DTXSID5046859 Css NA 0.01602 mg/L 3compartmentss NA 50% Human Human -DTXSID5046859 Css NA 0.1478 mg/L 3compartmentss NA 95% Human Human -DTXSID5046859 Css NA 0.01829 mg/L PBTK NA 50% Human Human -DTXSID5046859 Css NA 0.1273 mg/L PBTK NA 95% Human Human -DTXSID5046859 Clint NA 56.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046859 Fup NA 0.2989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046859 Vd NA 3.212 L/kg 1compartment NA NA Rat Human +DTXSID5046859 TK.Half.Life NA 2.885 hours 1compartment NA NA Human Human +DTXSID5046859 Css NA 0.1274 mg/L 3compartmentss NA 50% Human Human +DTXSID5046859 Css NA 0.9277 mg/L 3compartmentss NA 95% Human Human +DTXSID5046859 Css NA 0.1131 mg/L PBTK NA 50% Human Human +DTXSID5046859 Css NA 0.6855 mg/L PBTK NA 95% Human Human +DTXSID5046859 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046859 Fup 0.428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046859 Vd NA 1.588 L/kg 1compartment NA NA Rat Human DTXSID5046859 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046859 TK.Half.Life NA 1.077 hours 1compartment NA NA Rat Human -DTXSID5046859 Css NA 0.008394 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046859 Css NA 0.05984 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046859 Css NA 0.009468 mg/L PBTK NA 50% Rat Human -DTXSID5046859 Css NA 0.05316 mg/L PBTK NA 95% Rat Human -DTXSID5046938 Clint NA 0.6645 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046938 Fup NA 0.7154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046938 Vd NA 0.7579 L/kg 1compartment NA NA Human Human +DTXSID5046859 TK.Half.Life NA 1.641 hours 1compartment NA NA Rat Human +DTXSID5046859 Css NA 0.01437 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046859 Css NA 0.08417 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046859 Css NA 0.01308 mg/L PBTK NA 50% Rat Human +DTXSID5046859 Css NA 0.0594 mg/L PBTK NA 95% Rat Human +DTXSID5046934 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046934 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5046934 Vd NA 0.3726 L/kg 1compartment NA NA Human Human +DTXSID5046934 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5046934 TK.Half.Life NA 0.784 hours 1compartment NA NA Human Human +DTXSID5046934 Css NA 0.156 mg/L 3compartmentss NA 50% Human Human +DTXSID5046934 Css NA 1.045 mg/L 3compartmentss NA 95% Human Human +DTXSID5046934 Css NA 0.104 mg/L PBTK NA 50% Human Human +DTXSID5046934 Css NA 0.659 mg/L PBTK NA 95% Human Human +DTXSID5046934 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046934 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5046934 Vd NA 0.247 L/kg 1compartment NA NA Rat Human +DTXSID5046934 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5046934 TK.Half.Life NA 0.673 hours 1compartment NA NA Rat Human +DTXSID5046934 Css NA 0.0223 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046934 Css NA 0.1694 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046934 Css NA 0.01299 mg/L PBTK NA 50% Rat Human +DTXSID5046934 Css NA 0.0966 mg/L PBTK NA 95% Rat Human +DTXSID5046938 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046938 Fup 0.628 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046938 Vd NA 0.7397 L/kg 1compartment NA NA Human Human DTXSID5046938 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046938 TK.Half.Life NA 3.409 hours 1compartment NA NA Human Human -DTXSID5046938 Css NA 0.5073 mg/L 3compartmentss NA 50% Human Human -DTXSID5046938 Css NA 3.257 mg/L 3compartmentss NA 95% Human Human -DTXSID5046938 Css NA 0.4137 mg/L PBTK NA 50% Human Human -DTXSID5046938 Css NA 2.13 mg/L PBTK NA 95% Human Human -DTXSID5046938 Clint NA 0.6645 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046938 Fup NA 0.7154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046938 Vd NA 0.769 L/kg 1compartment NA NA Rat Human +DTXSID5046938 TK.Half.Life NA 7.67 hours 1compartment NA NA Human Human +DTXSID5046938 Css NA 1.142 mg/L 3compartmentss NA 50% Human Human +DTXSID5046938 Css NA 7.824 mg/L 3compartmentss NA 95% Human Human +DTXSID5046938 Css NA 0.9283 mg/L PBTK NA 50% Human Human +DTXSID5046938 Css NA 4.919 mg/L PBTK NA 95% Human Human +DTXSID5046938 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046938 Fup 0.628 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046938 Vd NA 0.7423 L/kg 1compartment NA NA Rat Human DTXSID5046938 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046938 TK.Half.Life NA 1.572 hours 1compartment NA NA Rat Human -DTXSID5046938 Css NA 0.1802 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046938 Css NA 1.143 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046938 Css NA 0.1438 mg/L PBTK NA 50% Rat Human -DTXSID5046938 Css NA 0.6861 mg/L PBTK NA 95% Rat Human -DTXSID5046980 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046980 Fup NA 0.3181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046980 Vd NA 0.3732 L/kg 1compartment NA NA Human Human +DTXSID5046938 TK.Half.Life NA 2.611 hours 1compartment NA NA Rat Human +DTXSID5046938 Css NA 0.06918 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046938 Css NA 0.4529 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046938 Css NA 0.0559 mg/L PBTK NA 50% Rat Human +DTXSID5046938 Css NA 0.2763 mg/L PBTK NA 95% Rat Human +DTXSID5046980 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046980 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5046980 Vd NA 0.2781 L/kg 1compartment NA NA Human Human DTXSID5046980 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046980 TK.Half.Life NA 7.599 hours 1compartment NA NA Human Human -DTXSID5046980 Css NA 2.503 mg/L 3compartmentss NA 50% Human Human -DTXSID5046980 Css NA 9.584 mg/L 3compartmentss NA 95% Human Human -DTXSID5046980 Css NA 1.682 mg/L PBTK NA 50% Human Human -DTXSID5046980 Css NA 5.883 mg/L PBTK NA 95% Human Human -DTXSID5046980 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046980 Fup NA 0.3181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046980 Vd NA 0.3733 L/kg 1compartment NA NA Rat Human +DTXSID5046980 TK.Half.Life NA 6.08 hours 1compartment NA NA Human Human +DTXSID5046980 Css NA 1.474 mg/L 3compartmentss NA 50% Human Human +DTXSID5046980 Css NA 6.028 mg/L 3compartmentss NA 95% Human Human +DTXSID5046980 Css NA 0.9536 mg/L PBTK NA 50% Human Human +DTXSID5046980 Css NA 3.611 mg/L PBTK NA 95% Human Human +DTXSID5046980 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046980 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5046980 Vd NA 0.2908 L/kg 1compartment NA NA Rat Human DTXSID5046980 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046980 TK.Half.Life NA 2.588 hours 1compartment NA NA Rat Human -DTXSID5046980 Css NA 0.6894 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046980 Css NA 2.252 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046980 Css NA 0.4393 mg/L PBTK NA 50% Rat Human -DTXSID5046980 Css NA 1.291 mg/L PBTK NA 95% Rat Human +DTXSID5046980 TK.Half.Life NA 2.166 hours 1compartment NA NA Rat Human +DTXSID5046980 Css NA 0.008133 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046980 Css NA 0.03292 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046980 Css NA 0.004954 mg/L PBTK NA 50% Rat Human +DTXSID5046980 Css NA 0.01896 mg/L PBTK NA 95% Rat Human DTXSID5046986 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5046986 Fup NA 0.7133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046986 Vd NA 0.5883 L/kg 1compartment NA NA Human Human +DTXSID5046986 Vd NA 0.62 L/kg 1compartment NA NA Human Human DTXSID5046986 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5046986 TK.Half.Life NA 5.336 hours 1compartment NA NA Human Human -DTXSID5046986 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human -DTXSID5046986 Css NA 7.144 mg/L 3compartmentss NA 95% Human Human -DTXSID5046986 Css NA 0.8702 mg/L PBTK NA 50% Human Human -DTXSID5046986 Css NA 4.461 mg/L PBTK NA 95% Human Human +DTXSID5046986 TK.Half.Life NA 5.622 hours 1compartment NA NA Human Human +DTXSID5046986 Css NA 0.9252 mg/L 3compartmentss NA 50% Human Human +DTXSID5046986 Css NA 6.091 mg/L 3compartmentss NA 95% Human Human +DTXSID5046986 Css NA 0.7363 mg/L PBTK NA 50% Human Human +DTXSID5046986 Css NA 3.917 mg/L PBTK NA 95% Human Human DTXSID5046986 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5046986 Fup NA 0.7133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046986 Vd NA 0.6261 L/kg 1compartment NA NA Rat Human +DTXSID5046986 Vd NA 0.6532 L/kg 1compartment NA NA Rat Human DTXSID5046986 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046986 TK.Half.Life NA 1.936 hours 1compartment NA NA Rat Human -DTXSID5046986 Css NA 0.29 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046986 Css NA 1.767 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046986 Css NA 0.219 mg/L PBTK NA 50% Rat Human -DTXSID5046986 Css NA 1.035 mg/L PBTK NA 95% Rat Human +DTXSID5046986 TK.Half.Life NA 2.02 hours 1compartment NA NA Rat Human +DTXSID5046986 Css NA 0.01784 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046986 Css NA 0.1475 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046986 Css NA 0.01372 mg/L PBTK NA 50% Rat Human +DTXSID5046986 Css NA 0.09254 mg/L PBTK NA 95% Rat Human DTXSID5046988 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5046988 Fup NA 0.8393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5046988 Vd NA 0.62 L/kg 1compartment NA NA Human Human +DTXSID5046988 Vd NA 0.6202 L/kg 1compartment NA NA Human Human DTXSID5046988 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5046988 TK.Half.Life NA 4.78 hours 1compartment NA NA Human Human -DTXSID5046988 Css NA 0.9986 mg/L 3compartmentss NA 50% Human Human -DTXSID5046988 Css NA 5.742 mg/L 3compartmentss NA 95% Human Human -DTXSID5046988 Css NA 0.7934 mg/L PBTK NA 50% Human Human -DTXSID5046988 Css NA 3.705 mg/L PBTK NA 95% Human Human +DTXSID5046988 Css NA 0.8548 mg/L 3compartmentss NA 50% Human Human +DTXSID5046988 Css NA 5.04 mg/L 3compartmentss NA 95% Human Human +DTXSID5046988 Css NA 0.679 mg/L PBTK NA 50% Human Human +DTXSID5046988 Css NA 3.228 mg/L PBTK NA 95% Human Human DTXSID5046988 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5046988 Fup NA 0.8393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5046988 Vd NA 0.6642 L/kg 1compartment NA NA Rat Human +DTXSID5046988 Vd NA 0.6645 L/kg 1compartment NA NA Rat Human DTXSID5046988 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5046988 TK.Half.Life NA 1.745 hours 1compartment NA NA Rat Human -DTXSID5046988 Css NA 0.2574 mg/L 3compartmentss NA 50% Rat Human -DTXSID5046988 Css NA 1.477 mg/L 3compartmentss NA 95% Rat Human -DTXSID5046988 Css NA 0.1978 mg/L PBTK NA 50% Rat Human -DTXSID5046988 Css NA 0.8737 mg/L PBTK NA 95% Rat Human -DTXSID5047031 Clint NA 28.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047031 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047031 Vd NA 2.878 L/kg 1compartment NA NA Human Human -DTXSID5047031 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5047031 TK.Half.Life NA 30.36 hours 1compartment NA NA Human Human -DTXSID5047031 Css NA 1.362 mg/L 3compartmentss NA 50% Human Human -DTXSID5047031 Css NA 9.315 mg/L 3compartmentss NA 95% Human Human -DTXSID5047031 Css NA 0.9396 mg/L PBTK NA 50% Human Human -DTXSID5047031 Css NA 6.161 mg/L PBTK NA 95% Human Human -DTXSID5047031 Clint NA 28.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047031 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047031 Vd NA 2.183 L/kg 1compartment NA NA Rat Human -DTXSID5047031 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5047031 TK.Half.Life NA 6.2 hours 1compartment NA NA Rat Human -DTXSID5047031 Css NA 0.7576 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047031 Css NA 4.257 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047031 Css NA 0.4957 mg/L PBTK NA 50% Rat Human -DTXSID5047031 Css NA 2.664 mg/L PBTK NA 95% Rat Human +DTXSID5046988 TK.Half.Life NA 1.746 hours 1compartment NA NA Rat Human +DTXSID5046988 Css NA 0.01578 mg/L 3compartmentss NA 50% Rat Human +DTXSID5046988 Css NA 0.1177 mg/L 3compartmentss NA 95% Rat Human +DTXSID5046988 Css NA 0.01218 mg/L PBTK NA 50% Rat Human +DTXSID5046988 Css NA 0.0759 mg/L PBTK NA 95% Rat Human +DTXSID5047031 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047031 Fup 0.0737 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047031 Vd NA 3.139 L/kg 1compartment NA NA Human Human +DTXSID5047031 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID5047031 TK.Half.Life NA 54.28 hours 1compartment NA NA Human Human +DTXSID5047031 Css NA 1.998 mg/L 3compartmentss NA 50% Human Human +DTXSID5047031 Css NA 12.85 mg/L 3compartmentss NA 95% Human Human +DTXSID5047031 Css NA 1.411 mg/L PBTK NA 50% Human Human +DTXSID5047031 Css NA 8.745 mg/L PBTK NA 95% Human Human +DTXSID5047031 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047031 Fup 0.0737 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047031 Vd NA 2.37 L/kg 1compartment NA NA Rat Human +DTXSID5047031 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID5047031 TK.Half.Life NA 7.898 hours 1compartment NA NA Rat Human +DTXSID5047031 Css NA 0.2566 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047031 Css NA 1.418 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047031 Css NA 0.1794 mg/L PBTK NA 50% Rat Human +DTXSID5047031 Css NA 0.9741 mg/L PBTK NA 95% Rat Human DTXSID5047033 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5047033 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047033 Vd NA 0.6449 L/kg 1compartment NA NA Human Human -DTXSID5047033 TK.Half.Life NA NA hours 1compartment NA NA Human Human -DTXSID5047033 Css NA NA mg/L 3compartmentss NA 50% Human Human -DTXSID5047033 Css NA NA mg/L 3compartmentss NA 95% Human Human -DTXSID5047033 Css NA NA mg/L PBTK NA 50% Human Human -DTXSID5047033 Css NA NA mg/L PBTK NA 95% Human Human +DTXSID5047033 Vd NA 1.657 L/kg 1compartment NA NA Human Human +DTXSID5047033 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5047033 TK.Half.Life NA 12.47 hours 1compartment NA NA Human Human +DTXSID5047033 Css NA 0.6254 mg/L 3compartmentss NA 50% Human Human +DTXSID5047033 Css NA 4.769 mg/L 3compartmentss NA 95% Human Human +DTXSID5047033 Css NA 0.6166 mg/L PBTK NA 50% Human Human +DTXSID5047033 Css NA 3.232 mg/L PBTK NA 95% Human Human DTXSID5047033 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5047033 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047033 Vd NA 0.7069 L/kg 1compartment NA NA Rat Human -DTXSID5047033 TK.Half.Life NA NA hours 1compartment NA NA Rat Human -DTXSID5047033 Css NA NA mg/L 3compartmentss NA 50% Rat Human -DTXSID5047033 Css NA NA mg/L 3compartmentss NA 95% Rat Human -DTXSID5047033 Css NA NA mg/L PBTK NA 50% Rat Human -DTXSID5047033 Css NA NA mg/L PBTK NA 95% Rat Human +DTXSID5047033 Vd NA 1.49 L/kg 1compartment NA NA Rat Human +DTXSID5047033 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047033 TK.Half.Life NA 3.413 hours 1compartment NA NA Rat Human +DTXSID5047033 Css NA 0.01126 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047033 Css NA 0.1011 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047033 Css NA 0.01089 mg/L PBTK NA 50% Rat Human +DTXSID5047033 Css NA 0.07145 mg/L PBTK NA 95% Rat Human DTXSID5047037 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5047037 Fup 0.0919 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5047037 Vd NA 0.3481 L/kg 1compartment NA NA Human Human -DTXSID5047037 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5047037 TK.Half.Life NA 24.51 hours 1compartment NA NA Human Human -DTXSID5047037 Css NA 8.568 mg/L 3compartmentss NA 50% Human Human -DTXSID5047037 Css NA 30.32 mg/L 3compartmentss NA 95% Human Human -DTXSID5047037 Css NA 5.483 mg/L PBTK NA 50% Human Human -DTXSID5047037 Css NA 18.45 mg/L PBTK NA 95% Human Human +DTXSID5047037 Vd NA 316.1 L/kg 1compartment NA NA Human Human +DTXSID5047037 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID5047037 TK.Half.Life NA 37190 hours 1compartment NA NA Human Human +DTXSID5047037 Css NA 0.1948 mg/L 3compartmentss NA 50% Human Human +DTXSID5047037 Css NA 1.15 mg/L 3compartmentss NA 95% Human Human +DTXSID5047037 Css NA 9.108 mg/L PBTK NA 50% Human Human +DTXSID5047037 Css NA 26.12 mg/L PBTK NA 95% Human Human DTXSID5047037 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5047037 Fup 0.0919 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5047037 Vd NA 0.3448 L/kg 1compartment NA NA Rat Human -DTXSID5047037 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047037 TK.Half.Life NA 8.272 hours 1compartment NA NA Rat Human -DTXSID5047037 Css NA 2.396 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047037 Css NA 7.036 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047037 Css NA 1.442 mg/L PBTK NA 50% Rat Human -DTXSID5047037 Css NA 3.957 mg/L PBTK NA 95% Rat Human -DTXSID5047039 Clint NA 8.065 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047039 Fup NA 0.1615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047039 Vd NA 3.038 L/kg 1compartment NA NA Human Human -DTXSID5047039 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5047039 TK.Half.Life NA 40.42 hours 1compartment NA NA Human Human -DTXSID5047039 Css NA 1.534 mg/L 3compartmentss NA 50% Human Human -DTXSID5047039 Css NA 8.876 mg/L 3compartmentss NA 95% Human Human -DTXSID5047039 Css NA 1.109 mg/L PBTK NA 50% Human Human -DTXSID5047039 Css NA 6.164 mg/L PBTK NA 95% Human Human -DTXSID5047039 Clint NA 8.065 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047039 Fup NA 0.1615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047039 Vd NA 2.331 L/kg 1compartment NA NA Rat Human -DTXSID5047039 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5047039 TK.Half.Life NA 7.305 hours 1compartment NA NA Rat Human -DTXSID5047039 Css NA 0.8171 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047039 Css NA 3.484 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047039 Css NA 0.5688 mg/L PBTK NA 50% Rat Human -DTXSID5047039 Css NA 2.337 mg/L PBTK NA 95% Rat Human -DTXSID5047085 Clint NA 2.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047085 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047085 Vd NA 0.9998 L/kg 1compartment NA NA Human Human +DTXSID5047037 Vd NA 282.4 L/kg 1compartment NA NA Rat Human +DTXSID5047037 Days.Css NA 3176 Days PBTK NA NA Rat Human +DTXSID5047037 TK.Half.Life NA 7858 hours 1compartment NA NA Rat Human +DTXSID5047037 Css NA 0.01068 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047037 Css NA 0.05656 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047037 Css NA 0.5718 mg/L PBTK NA 50% Rat Human +DTXSID5047037 Css NA 1.327 mg/L PBTK NA 95% Rat Human +DTXSID5047039 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047039 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047039 Vd NA 2.297 L/kg 1compartment NA NA Human Human +DTXSID5047039 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047039 TK.Half.Life NA 4.99 hours 1compartment NA NA Human Human +DTXSID5047039 Css NA 0.1656 mg/L 3compartmentss NA 50% Human Human +DTXSID5047039 Css NA 1.225 mg/L 3compartmentss NA 95% Human Human +DTXSID5047039 Css NA 0.1246 mg/L PBTK NA 50% Human Human +DTXSID5047039 Css NA 0.8643 mg/L PBTK NA 95% Human Human +DTXSID5047039 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047039 Fup 0.175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047039 Vd NA 1.868 L/kg 1compartment NA NA Rat Human +DTXSID5047039 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047039 TK.Half.Life NA 1.809 hours 1compartment NA NA Rat Human +DTXSID5047039 Css NA 0.02133 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047039 Css NA 0.1124 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047039 Css NA 0.01601 mg/L PBTK NA 50% Rat Human +DTXSID5047039 Css NA 0.08024 mg/L PBTK NA 95% Rat Human +DTXSID5047085 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047085 Fup 0.727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047085 Vd NA 0.822 L/kg 1compartment NA NA Human Human DTXSID5047085 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047085 TK.Half.Life NA 1.667 hours 1compartment NA NA Human Human -DTXSID5047085 Css NA 0.1655 mg/L 3compartmentss NA 50% Human Human -DTXSID5047085 Css NA 1.327 mg/L 3compartmentss NA 95% Human Human -DTXSID5047085 Css NA 0.1454 mg/L PBTK NA 50% Human Human -DTXSID5047085 Css NA 0.9326 mg/L PBTK NA 95% Human Human -DTXSID5047085 Clint NA 2.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047085 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047085 Vd NA 1.002 L/kg 1compartment NA NA Rat Human +DTXSID5047085 TK.Half.Life NA 7.375 hours 1compartment NA NA Human Human +DTXSID5047085 Css NA 0.9996 mg/L 3compartmentss NA 50% Human Human +DTXSID5047085 Css NA 6.649 mg/L 3compartmentss NA 95% Human Human +DTXSID5047085 Css NA 0.8361 mg/L PBTK NA 50% Human Human +DTXSID5047085 Css NA 4.267 mg/L PBTK NA 95% Human Human +DTXSID5047085 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047085 Fup 0.727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047085 Vd NA 0.8229 L/kg 1compartment NA NA Rat Human DTXSID5047085 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047085 TK.Half.Life NA 0.8628 hours 1compartment NA NA Rat Human -DTXSID5047085 Css NA 0.07036 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047085 Css NA 0.5088 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047085 Css NA 0.0615 mg/L PBTK NA 50% Rat Human -DTXSID5047085 Css NA 0.3146 mg/L PBTK NA 95% Rat Human -DTXSID5047087 Clint NA 211.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047087 Fup NA 0.3905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047087 Vd NA 1.606 L/kg 1compartment NA NA Human Human +DTXSID5047085 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human +DTXSID5047085 Css NA 0.06006 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047085 Css NA 0.3803 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047085 Css NA 0.05034 mg/L PBTK NA 50% Rat Human +DTXSID5047085 Css NA 0.2354 mg/L PBTK NA 95% Rat Human +DTXSID5047087 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047087 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047087 Vd NA 1.316 L/kg 1compartment NA NA Human Human DTXSID5047087 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047087 TK.Half.Life NA 1.18 hours 1compartment NA NA Human Human -DTXSID5047087 Css NA 0.00649 mg/L 3compartmentss NA 50% Human Human -DTXSID5047087 Css NA 0.04888 mg/L 3compartmentss NA 95% Human Human -DTXSID5047087 Css NA 0.005122 mg/L PBTK NA 50% Human Human -DTXSID5047087 Css NA 0.0354 mg/L PBTK NA 95% Human Human -DTXSID5047087 Clint NA 211.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047087 Fup NA 0.3905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047087 Vd NA 1.314 L/kg 1compartment NA NA Rat Human +DTXSID5047087 TK.Half.Life NA 1.921 hours 1compartment NA NA Human Human +DTXSID5047087 Css NA 0.08598 mg/L 3compartmentss NA 50% Human Human +DTXSID5047087 Css NA 0.6047 mg/L 3compartmentss NA 95% Human Human +DTXSID5047087 Css NA 0.0634 mg/L PBTK NA 50% Human Human +DTXSID5047087 Css NA 0.4146 mg/L PBTK NA 95% Human Human +DTXSID5047087 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047087 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047087 Vd NA 1.071 L/kg 1compartment NA NA Rat Human DTXSID5047087 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047087 TK.Half.Life NA 0.4247 hours 1compartment NA NA Rat Human -DTXSID5047087 Css NA 0.003553 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047087 Css NA 0.02296 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047087 Css NA 0.002732 mg/L PBTK NA 50% Rat Human -DTXSID5047087 Css NA 0.01589 mg/L PBTK NA 95% Rat Human -DTXSID5047110 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047110 Fup NA 0.0255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047110 Vd NA 3.223 L/kg 1compartment NA NA Human Human -DTXSID5047110 Days.Css NA 24 Days PBTK NA NA Human Human -DTXSID5047110 TK.Half.Life NA 135.3 hours 1compartment NA NA Human Human -DTXSID5047110 Css NA 4.752 mg/L 3compartmentss NA 50% Human Human -DTXSID5047110 Css NA 27.93 mg/L 3compartmentss NA 95% Human Human -DTXSID5047110 Css NA 3.345 mg/L PBTK NA 50% Human Human -DTXSID5047110 Css NA 19.48 mg/L PBTK NA 95% Human Human -DTXSID5047110 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047110 Fup NA 0.0255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047110 Vd NA 2.418 L/kg 1compartment NA NA Rat Human -DTXSID5047110 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID5047110 TK.Half.Life NA 17.78 hours 1compartment NA NA Rat Human -DTXSID5047110 Css NA 2.765 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047110 Css NA 11.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047110 Css NA 1.854 mg/L PBTK NA 50% Rat Human -DTXSID5047110 Css NA 7.794 mg/L PBTK NA 95% Rat Human -DTXSID5047112 Clint NA 312.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047112 Fup NA 0.0915 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047112 Vd NA 4.007 L/kg 1compartment NA NA Human Human -DTXSID5047112 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047112 TK.Half.Life NA 2.455 hours 1compartment NA NA Human Human -DTXSID5047112 Css NA 0.003328 mg/L 3compartmentss NA 50% Human Human -DTXSID5047112 Css NA 0.02565 mg/L 3compartmentss NA 95% Human Human -DTXSID5047112 Css NA 0.003078 mg/L PBTK NA 50% Human Human -DTXSID5047112 Css NA 0.02138 mg/L PBTK NA 95% Human Human -DTXSID5047112 Clint NA 312.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047112 Fup NA 0.0915 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047112 Vd NA 3.501 L/kg 1compartment NA NA Rat Human -DTXSID5047112 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047112 TK.Half.Life NA 0.9235 hours 1compartment NA NA Rat Human -DTXSID5047112 Css NA 0.001819 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047112 Css NA 0.01152 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047112 Css NA 0.001644 mg/L PBTK NA 50% Rat Human -DTXSID5047112 Css NA 0.009257 mg/L PBTK NA 95% Rat Human -DTXSID5047116 Clint NA 2.395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047116 Fup NA 0.2989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047116 Vd NA 2.284 L/kg 1compartment NA NA Human Human -DTXSID5047116 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5047116 TK.Half.Life NA 19.71 hours 1compartment NA NA Human Human -DTXSID5047116 Css NA 0.9356 mg/L 3compartmentss NA 50% Human Human -DTXSID5047116 Css NA 4.167 mg/L 3compartmentss NA 95% Human Human -DTXSID5047116 Css NA 0.71 mg/L PBTK NA 50% Human Human -DTXSID5047116 Css NA 2.894 mg/L PBTK NA 95% Human Human -DTXSID5047116 Clint NA 2.395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047116 Fup NA 0.2989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047116 Vd NA 1.77 L/kg 1compartment NA NA Rat Human +DTXSID5047087 TK.Half.Life NA 0.7904 hours 1compartment NA NA Rat Human +DTXSID5047087 Css NA 0.01086 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047087 Css NA 0.05682 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047087 Css NA 0.007956 mg/L PBTK NA 50% Rat Human +DTXSID5047087 Css NA 0.03915 mg/L PBTK NA 95% Rat Human +DTXSID5047089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047089 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047089 Vd NA 1.201 L/kg 1compartment NA NA Human Human +DTXSID5047089 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047089 TK.Half.Life NA 1.473 hours 1compartment NA NA Human Human +DTXSID5047089 Css NA 0.06063 mg/L 3compartmentss NA 50% Human Human +DTXSID5047089 Css NA 0.4647 mg/L 3compartmentss NA 95% Human Human +DTXSID5047089 Css NA 0.04643 mg/L PBTK NA 50% Human Human +DTXSID5047089 Css NA 0.3222 mg/L PBTK NA 95% Human Human +DTXSID5047089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047089 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047089 Vd NA 1.012 L/kg 1compartment NA NA Rat Human +DTXSID5047089 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047089 TK.Half.Life NA 0.6261 hours 1compartment NA NA Rat Human +DTXSID5047089 Css NA 0.007552 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047089 Css NA 0.04368 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047089 Css NA 0.00576 mg/L PBTK NA 50% Rat Human +DTXSID5047089 Css NA 0.03072 mg/L PBTK NA 95% Rat Human +DTXSID5047110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047110 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047110 Vd NA 4.755 L/kg 1compartment NA NA Human Human +DTXSID5047110 Days.Css NA 26 Days PBTK NA NA Human Human +DTXSID5047110 TK.Half.Life NA 143 hours 1compartment NA NA Human Human +DTXSID5047110 Css NA 2.994 mg/L 3compartmentss NA 50% Human Human +DTXSID5047110 Css NA 17.42 mg/L 3compartmentss NA 95% Human Human +DTXSID5047110 Css NA 2.392 mg/L PBTK NA 50% Human Human +DTXSID5047110 Css NA 13.63 mg/L PBTK NA 95% Human Human +DTXSID5047110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047110 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047110 Vd NA 3.623 L/kg 1compartment NA NA Rat Human +DTXSID5047110 Days.Css NA 15 Days PBTK NA NA Rat Human +DTXSID5047110 TK.Half.Life NA 19.35 hours 1compartment NA NA Rat Human +DTXSID5047110 Css NA 0.3862 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047110 Css NA 1.95 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047110 Css NA 0.3078 mg/L PBTK NA 50% Rat Human +DTXSID5047110 Css NA 1.56 mg/L PBTK NA 95% Rat Human +DTXSID5047116 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047116 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047116 Vd NA 1.824 L/kg 1compartment NA NA Human Human +DTXSID5047116 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047116 TK.Half.Life NA 2.819 hours 1compartment NA NA Human Human +DTXSID5047116 Css NA 0.0934 mg/L 3compartmentss NA 50% Human Human +DTXSID5047116 Css NA 0.6891 mg/L 3compartmentss NA 95% Human Human +DTXSID5047116 Css NA 0.0707 mg/L PBTK NA 50% Human Human +DTXSID5047116 Css NA 0.4857 mg/L PBTK NA 95% Human Human +DTXSID5047116 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047116 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047116 Vd NA 1.439 L/kg 1compartment NA NA Rat Human DTXSID5047116 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047116 TK.Half.Life NA 5.328 hours 1compartment NA NA Rat Human -DTXSID5047116 Css NA 0.4374 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047116 Css NA 1.373 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047116 Css NA 0.3211 mg/L PBTK NA 50% Rat Human -DTXSID5047116 Css NA 0.8898 mg/L PBTK NA 95% Rat Human -DTXSID5047118 Clint NA 0.571 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047118 Fup NA 0.3968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047118 Vd NA 1.301 L/kg 1compartment NA NA Human Human -DTXSID5047118 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5047118 TK.Half.Life NA 12.7 hours 1compartment NA NA Human Human -DTXSID5047118 Css NA 0.9984 mg/L 3compartmentss NA 50% Human Human -DTXSID5047118 Css NA 4.467 mg/L 3compartmentss NA 95% Human Human -DTXSID5047118 Css NA 0.7917 mg/L PBTK NA 50% Human Human -DTXSID5047118 Css NA 2.961 mg/L PBTK NA 95% Human Human -DTXSID5047118 Clint NA 0.571 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047118 Fup NA 0.3968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047118 Vd NA 1.09 L/kg 1compartment NA NA Rat Human -DTXSID5047118 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047118 TK.Half.Life NA 4.287 hours 1compartment NA NA Rat Human -DTXSID5047118 Css NA 0.3694 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047118 Css NA 1.393 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047118 Css NA 0.28 mg/L PBTK NA 50% Rat Human -DTXSID5047118 Css NA 0.852 mg/L PBTK NA 95% Rat Human -DTXSID5047164 Clint NA 0.01361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047164 Fup NA 0.5295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047164 Vd NA 1.731 L/kg 1compartment NA NA Human Human -DTXSID5047164 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5047164 TK.Half.Life NA 27.6 hours 1compartment NA NA Human Human -DTXSID5047164 Css NA 1.598 mg/L 3compartmentss NA 50% Human Human -DTXSID5047164 Css NA 8.144 mg/L 3compartmentss NA 95% Human Human -DTXSID5047164 Css NA 1.364 mg/L PBTK NA 50% Human Human -DTXSID5047164 Css NA 5.452 mg/L PBTK NA 95% Human Human -DTXSID5047164 Clint NA 0.01361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047164 Fup NA 0.5295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047164 Vd NA 1.437 L/kg 1compartment NA NA Rat Human +DTXSID5047116 TK.Half.Life NA 1.03 hours 1compartment NA NA Rat Human +DTXSID5047116 Css NA 0.01189 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047116 Css NA 0.06301 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047116 Css NA 0.008964 mg/L PBTK NA 50% Rat Human +DTXSID5047116 Css NA 0.04451 mg/L PBTK NA 95% Rat Human +DTXSID5047164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047164 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047164 Vd NA 1.347 L/kg 1compartment NA NA Human Human +DTXSID5047164 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047164 TK.Half.Life NA 1.478 hours 1compartment NA NA Human Human +DTXSID5047164 Css NA 0.04774 mg/L 3compartmentss NA 50% Human Human +DTXSID5047164 Css NA 0.4209 mg/L 3compartmentss NA 95% Human Human +DTXSID5047164 Css NA 0.03853 mg/L PBTK NA 50% Human Human +DTXSID5047164 Css NA 0.2948 mg/L PBTK NA 95% Human Human +DTXSID5047164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047164 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047164 Vd NA 1.14 L/kg 1compartment NA NA Rat Human DTXSID5047164 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047164 TK.Half.Life NA 6.388 hours 1compartment NA NA Rat Human -DTXSID5047164 Css NA 0.4368 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047164 Css NA 2.053 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047164 Css NA 0.359 mg/L PBTK NA 50% Rat Human -DTXSID5047164 Css NA 1.272 mg/L PBTK NA 95% Rat Human -DTXSID5047166 Clint NA 31.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047166 Fup NA 0.2941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047166 Vd NA 2.336 L/kg 1compartment NA NA Human Human +DTXSID5047164 TK.Half.Life NA 0.6161 hours 1compartment NA NA Rat Human +DTXSID5047164 Css NA 0.005909 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047164 Css NA 0.03744 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047164 Css NA 0.004772 mg/L PBTK NA 50% Rat Human +DTXSID5047164 Css NA 0.02643 mg/L PBTK NA 95% Rat Human +DTXSID5047166 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047166 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047166 Vd NA 1.315 L/kg 1compartment NA NA Human Human DTXSID5047166 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047166 TK.Half.Life NA 3.474 hours 1compartment NA NA Human Human -DTXSID5047166 Css NA 0.09234 mg/L 3compartmentss NA 50% Human Human -DTXSID5047166 Css NA 0.6196 mg/L 3compartmentss NA 95% Human Human -DTXSID5047166 Css NA 0.0691 mg/L PBTK NA 50% Human Human -DTXSID5047166 Css NA 0.441 mg/L PBTK NA 95% Human Human -DTXSID5047166 Clint NA 31.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047166 Fup NA 0.2941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047166 Vd NA 1.806 L/kg 1compartment NA NA Rat Human +DTXSID5047166 TK.Half.Life NA 1.847 hours 1compartment NA NA Human Human +DTXSID5047166 Css NA 0.07813 mg/L 3compartmentss NA 50% Human Human +DTXSID5047166 Css NA 0.5703 mg/L 3compartmentss NA 95% Human Human +DTXSID5047166 Css NA 0.05826 mg/L PBTK NA 50% Human Human +DTXSID5047166 Css NA 0.3888 mg/L PBTK NA 95% Human Human +DTXSID5047166 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047166 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047166 Vd NA 1.076 L/kg 1compartment NA NA Rat Human DTXSID5047166 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047166 TK.Half.Life NA 1.092 hours 1compartment NA NA Rat Human -DTXSID5047166 Css NA 0.04978 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047166 Css NA 0.2543 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047166 Css NA 0.03628 mg/L PBTK NA 50% Rat Human -DTXSID5047166 Css NA 0.1737 mg/L PBTK NA 95% Rat Human -DTXSID5047168 Clint NA 7.294 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047168 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047168 Vd NA 3.008 L/kg 1compartment NA NA Human Human -DTXSID5047168 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID5047168 TK.Half.Life NA 85.1 hours 1compartment NA NA Human Human -DTXSID5047168 Css NA 3.536 mg/L 3compartmentss NA 50% Human Human -DTXSID5047168 Css NA 20.39 mg/L 3compartmentss NA 95% Human Human -DTXSID5047168 Css NA 2.458 mg/L PBTK NA 50% Human Human -DTXSID5047168 Css NA 13.6 mg/L PBTK NA 95% Human Human -DTXSID5047168 Clint NA 7.294 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047168 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047168 Vd NA 2.258 L/kg 1compartment NA NA Rat Human -DTXSID5047168 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID5047168 TK.Half.Life NA 13.13 hours 1compartment NA NA Rat Human -DTXSID5047168 Css NA 1.907 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047168 Css NA 8.425 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047168 Css NA 1.268 mg/L PBTK NA 50% Rat Human -DTXSID5047168 Css NA 5.412 mg/L PBTK NA 95% Rat Human +DTXSID5047166 TK.Half.Life NA 0.7616 hours 1compartment NA NA Rat Human +DTXSID5047166 Css NA 0.009918 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047166 Css NA 0.05479 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047166 Css NA 0.00738 mg/L PBTK NA 50% Rat Human +DTXSID5047166 Css NA 0.03742 mg/L PBTK NA 95% Rat Human +DTXSID5047168 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047168 Fup 0.0375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047168 Vd NA 3.053 L/kg 1compartment NA NA Human Human +DTXSID5047168 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID5047168 TK.Half.Life NA 57.28 hours 1compartment NA NA Human Human +DTXSID5047168 Css NA 2.216 mg/L 3compartmentss NA 50% Human Human +DTXSID5047168 Css NA 14.95 mg/L 3compartmentss NA 95% Human Human +DTXSID5047168 Css NA 1.528 mg/L PBTK NA 50% Human Human +DTXSID5047168 Css NA 10.11 mg/L PBTK NA 95% Human Human +DTXSID5047168 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047168 Fup 0.0375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047168 Vd NA 2.287 L/kg 1compartment NA NA Rat Human +DTXSID5047168 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID5047168 TK.Half.Life NA 8.606 hours 1compartment NA NA Rat Human +DTXSID5047168 Css NA 0.2921 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047168 Css NA 1.622 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047168 Css NA 0.1997 mg/L PBTK NA 50% Rat Human +DTXSID5047168 Css NA 1.073 mg/L PBTK NA 95% Rat Human DTXSID5047241 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5047241 Fup NA 0.8201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047241 Vd NA 0.4245 L/kg 1compartment NA NA Human Human +DTXSID5047241 Vd NA 0.4452 L/kg 1compartment NA NA Human Human DTXSID5047241 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047241 TK.Half.Life NA 3.349 hours 1compartment NA NA Human Human -DTXSID5047241 Css NA 1.102 mg/L 3compartmentss NA 50% Human Human -DTXSID5047241 Css NA 6.136 mg/L 3compartmentss NA 95% Human Human -DTXSID5047241 Css NA 0.7996 mg/L PBTK NA 50% Human Human -DTXSID5047241 Css NA 3.811 mg/L PBTK NA 95% Human Human +DTXSID5047241 TK.Half.Life NA 3.513 hours 1compartment NA NA Human Human +DTXSID5047241 Css NA 0.5994 mg/L 3compartmentss NA 50% Human Human +DTXSID5047241 Css NA 3.477 mg/L 3compartmentss NA 95% Human Human +DTXSID5047241 Css NA 0.4392 mg/L PBTK NA 50% Human Human +DTXSID5047241 Css NA 2.169 mg/L PBTK NA 95% Human Human DTXSID5047241 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5047241 Fup NA 0.8201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047241 Vd NA 0.4505 L/kg 1compartment NA NA Rat Human +DTXSID5047241 Vd NA 0.468 L/kg 1compartment NA NA Rat Human DTXSID5047241 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047241 TK.Half.Life NA 1.211 hours 1compartment NA NA Rat Human -DTXSID5047241 Css NA 0.2882 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047241 Css NA 1.574 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047241 Css NA 0.1998 mg/L PBTK NA 50% Rat Human -DTXSID5047241 Css NA 0.9037 mg/L PBTK NA 95% Rat Human -DTXSID5047243 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047243 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047243 Vd NA 0.45 L/kg 1compartment NA NA Human Human -DTXSID5047243 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID5047243 TK.Half.Life NA 58.2 hours 1compartment NA NA Human Human -DTXSID5047243 Css NA 21.18 mg/L 3compartmentss NA 50% Human Human -DTXSID5047243 Css NA 102.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5047243 Css NA 12.84 mg/L PBTK NA 50% Human Human -DTXSID5047243 Css NA 60.24 mg/L PBTK NA 95% Human Human -DTXSID5047243 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047243 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047243 Vd NA 0.3703 L/kg 1compartment NA NA Rat Human -DTXSID5047243 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5047243 TK.Half.Life NA 16.01 hours 1compartment NA NA Rat Human -DTXSID5047243 Css NA 6.035 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047243 Css NA 24.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047243 Css NA 3.426 mg/L PBTK NA 50% Rat Human -DTXSID5047243 Css NA 13.51 mg/L PBTK NA 95% Rat Human -DTXSID5047249 Clint NA 16.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047249 Fup NA 0.0029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047249 Vd NA 0.3936 L/kg 1compartment NA NA Human Human -DTXSID5047249 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5047249 TK.Half.Life NA 25.21 hours 1compartment NA NA Human Human -DTXSID5047249 Css NA 12.06 mg/L 3compartmentss NA 50% Human Human -DTXSID5047249 Css NA 87.28 mg/L 3compartmentss NA 95% Human Human -DTXSID5047249 Css NA 7.178 mg/L PBTK NA 50% Human Human -DTXSID5047249 Css NA 51.75 mg/L PBTK NA 95% Human Human -DTXSID5047249 Clint NA 16.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047249 Fup NA 0.0029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047249 Vd NA 0.3236 L/kg 1compartment NA NA Rat Human -DTXSID5047249 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5047249 TK.Half.Life NA 13.85 hours 1compartment NA NA Rat Human -DTXSID5047249 Css NA 6.967 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047249 Css NA 36.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047249 Css NA 3.856 mg/L PBTK NA 50% Rat Human -DTXSID5047249 Css NA 20 mg/L PBTK NA 95% Rat Human -DTXSID5047291 Clint NA 39.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5047241 TK.Half.Life NA 1.258 hours 1compartment NA NA Rat Human +DTXSID5047241 Css NA 0.003118 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047241 Css NA 0.01914 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047241 Css NA 0.002188 mg/L PBTK NA 50% Rat Human +DTXSID5047241 Css NA 0.01131 mg/L PBTK NA 95% Rat Human +DTXSID5047243 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047243 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047243 Vd NA 0.5777 L/kg 1compartment NA NA Human Human +DTXSID5047243 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5047243 TK.Half.Life NA 16.75 hours 1compartment NA NA Human Human +DTXSID5047243 Css NA 2.923 mg/L 3compartmentss NA 50% Human Human +DTXSID5047243 Css NA 10.96 mg/L 3compartmentss NA 95% Human Human +DTXSID5047243 Css NA 2.006 mg/L PBTK NA 50% Human Human +DTXSID5047243 Css NA 6.884 mg/L PBTK NA 95% Human Human +DTXSID5047243 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047243 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047243 Vd NA 0.5128 L/kg 1compartment NA NA Rat Human +DTXSID5047243 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047243 TK.Half.Life NA 4.969 hours 1compartment NA NA Rat Human +DTXSID5047243 Css NA 0.05312 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047243 Css NA 0.3059 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047243 Css NA 0.0348 mg/L PBTK NA 50% Rat Human +DTXSID5047243 Css NA 0.1874 mg/L PBTK NA 95% Rat Human +DTXSID5047249 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047249 Fup 0.0196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047249 Vd NA 1.217 L/kg 1compartment NA NA Human Human +DTXSID5047249 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047249 TK.Half.Life NA 10.79 hours 1compartment NA NA Human Human +DTXSID5047249 Css NA 1.13 mg/L 3compartmentss NA 50% Human Human +DTXSID5047249 Css NA 12.42 mg/L 3compartmentss NA 95% Human Human +DTXSID5047249 Css NA 0.7716 mg/L PBTK NA 50% Human Human +DTXSID5047249 Css NA 7.679 mg/L PBTK NA 95% Human Human +DTXSID5047249 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047249 Fup 0.0196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047249 Vd NA 0.9801 L/kg 1compartment NA NA Rat Human +DTXSID5047249 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047249 TK.Half.Life NA 5.2 hours 1compartment NA NA Rat Human +DTXSID5047249 Css NA 0.0556 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047249 Css NA 0.6346 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047249 Css NA 0.0372 mg/L PBTK NA 50% Rat Human +DTXSID5047249 Css NA 0.3797 mg/L PBTK NA 95% Rat Human +DTXSID5047291 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5047291 Fup 0.198 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5047291 Vd NA 1.39 L/kg 1compartment NA NA Human Human +DTXSID5047291 Vd NA 1.465 L/kg 1compartment NA NA Human Human DTXSID5047291 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047291 TK.Half.Life NA 1.837 hours 1compartment NA NA Human Human -DTXSID5047291 Css NA 0.06559 mg/L 3compartmentss NA 50% Human Human -DTXSID5047291 Css NA 0.4187 mg/L 3compartmentss NA 95% Human Human -DTXSID5047291 Css NA 0.04699 mg/L PBTK NA 50% Human Human -DTXSID5047291 Css NA 0.2872 mg/L PBTK NA 95% Human Human -DTXSID5047291 Clint NA 39.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5047291 TK.Half.Life NA 5.975 hours 1compartment NA NA Human Human +DTXSID5047291 Css NA 0.3788 mg/L 3compartmentss NA 50% Human Human +DTXSID5047291 Css NA 2.052 mg/L 3compartmentss NA 95% Human Human +DTXSID5047291 Css NA 0.2728 mg/L PBTK NA 50% Human Human +DTXSID5047291 Css NA 1.4 mg/L PBTK NA 95% Human Human +DTXSID5047291 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5047291 Fup 0.198 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5047291 Vd NA 1.101 L/kg 1compartment NA NA Rat Human +DTXSID5047291 Vd NA 1.155 L/kg 1compartment NA NA Rat Human DTXSID5047291 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047291 TK.Half.Life NA 0.7125 hours 1compartment NA NA Rat Human -DTXSID5047291 Css NA 0.03606 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047291 Css NA 0.182 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047291 Css NA 0.02473 mg/L PBTK NA 50% Rat Human -DTXSID5047291 Css NA 0.1177 mg/L PBTK NA 95% Rat Human -DTXSID5047295 Clint NA 7.722 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047295 Fup NA 0.105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047295 Vd NA 2.393 L/kg 1compartment NA NA Human Human +DTXSID5047291 TK.Half.Life NA 2.377 hours 1compartment NA NA Rat Human +DTXSID5047291 Css NA 0.04552 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047291 Css NA 0.1624 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047291 Css NA 0.03251 mg/L PBTK NA 50% Rat Human +DTXSID5047291 Css NA 0.1115 mg/L PBTK NA 95% Rat Human +DTXSID5047295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047295 Fup 0.0994 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047295 Vd NA 2.331 L/kg 1compartment NA NA Human Human DTXSID5047295 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047295 TK.Half.Life NA 9.803 hours 1compartment NA NA Human Human -DTXSID5047295 Css NA 0.4358 mg/L 3compartmentss NA 50% Human Human -DTXSID5047295 Css NA 3.6 mg/L 3compartmentss NA 95% Human Human -DTXSID5047295 Css NA 0.3645 mg/L PBTK NA 50% Human Human -DTXSID5047295 Css NA 2.501 mg/L PBTK NA 95% Human Human -DTXSID5047295 Clint NA 7.722 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047295 Fup NA 0.105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047295 Vd NA 2.325 L/kg 1compartment NA NA Rat Human +DTXSID5047295 TK.Half.Life NA 9.165 hours 1compartment NA NA Human Human +DTXSID5047295 Css NA 0.4359 mg/L 3compartmentss NA 50% Human Human +DTXSID5047295 Css NA 3.031 mg/L 3compartmentss NA 95% Human Human +DTXSID5047295 Css NA 0.297 mg/L PBTK NA 50% Human Human +DTXSID5047295 Css NA 2.003 mg/L PBTK NA 95% Human Human +DTXSID5047295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047295 Fup 0.0994 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047295 Vd NA 1.759 L/kg 1compartment NA NA Rat Human DTXSID5047295 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047295 TK.Half.Life NA 5.613 hours 1compartment NA NA Rat Human -DTXSID5047295 Css NA 0.2339 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047295 Css NA 1.501 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047295 Css NA 0.1888 mg/L PBTK NA 50% Rat Human -DTXSID5047295 Css NA 0.9619 mg/L PBTK NA 95% Rat Human -DTXSID5047297 Clint NA 17.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047297 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047297 Vd NA 1.708 L/kg 1compartment NA NA Human Human -DTXSID5047297 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID5047297 TK.Half.Life NA 51.27 hours 1compartment NA NA Human Human -DTXSID5047297 Css NA 5.062 mg/L 3compartmentss NA 50% Human Human -DTXSID5047297 Css NA 40.6 mg/L 3compartmentss NA 95% Human Human -DTXSID5047297 Css NA 3.16 mg/L PBTK NA 50% Human Human -DTXSID5047297 Css NA 24.24 mg/L PBTK NA 95% Human Human -DTXSID5047297 Clint NA 17.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047297 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047297 Vd NA 1.257 L/kg 1compartment NA NA Rat Human -DTXSID5047297 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5047297 TK.Half.Life NA 18.37 hours 1compartment NA NA Rat Human -DTXSID5047297 Css NA 2.821 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047297 Css NA 19.58 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047297 Css NA 1.648 mg/L PBTK NA 50% Rat Human -DTXSID5047297 Css NA 11.04 mg/L PBTK NA 95% Rat Human -DTXSID5047299 Clint NA 49.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047299 Fup NA 0.0174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047299 Vd NA 1.562 L/kg 1compartment NA NA Human Human +DTXSID5047295 TK.Half.Life NA 2.638 hours 1compartment NA NA Rat Human +DTXSID5047295 Css NA 0.05572 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047295 Css NA 0.3056 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047295 Css NA 0.03767 mg/L PBTK NA 50% Rat Human +DTXSID5047295 Css NA 0.1983 mg/L PBTK NA 95% Rat Human +DTXSID5047297 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047297 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047297 Vd NA 2.671 L/kg 1compartment NA NA Human Human +DTXSID5047297 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5047297 TK.Half.Life NA 40.77 hours 1compartment NA NA Human Human +DTXSID5047297 Css NA 1.818 mg/L 3compartmentss NA 50% Human Human +DTXSID5047297 Css NA 13.2 mg/L 3compartmentss NA 95% Human Human +DTXSID5047297 Css NA 1.211 mg/L PBTK NA 50% Human Human +DTXSID5047297 Css NA 8.469 mg/L PBTK NA 95% Human Human +DTXSID5047297 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047297 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047297 Vd NA 1.993 L/kg 1compartment NA NA Rat Human +DTXSID5047297 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5047297 TK.Half.Life NA 8.873 hours 1compartment NA NA Rat Human +DTXSID5047297 Css NA 0.09357 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047297 Css NA 0.7016 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047297 Css NA 0.06054 mg/L PBTK NA 50% Rat Human +DTXSID5047297 Css NA 0.427 mg/L PBTK NA 95% Rat Human +DTXSID5047299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047299 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047299 Vd NA 0.5969 L/kg 1compartment NA NA Human Human DTXSID5047299 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047299 TK.Half.Life NA 2.146 hours 1compartment NA NA Human Human -DTXSID5047299 Css NA 0.09629 mg/L 3compartmentss NA 50% Human Human -DTXSID5047299 Css NA 1.122 mg/L 3compartmentss NA 95% Human Human -DTXSID5047299 Css NA 0.06786 mg/L PBTK NA 50% Human Human -DTXSID5047299 Css NA 0.7019 mg/L PBTK NA 95% Human Human -DTXSID5047299 Clint NA 49.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047299 Fup NA 0.0174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047299 Vd NA 1.443 L/kg 1compartment NA NA Rat Human +DTXSID5047299 TK.Half.Life NA 1.085 hours 1compartment NA NA Human Human +DTXSID5047299 Css NA 0.1264 mg/L 3compartmentss NA 50% Human Human +DTXSID5047299 Css NA 0.9193 mg/L 3compartmentss NA 95% Human Human +DTXSID5047299 Css NA 0.08606 mg/L PBTK NA 50% Human Human +DTXSID5047299 Css NA 0.5887 mg/L PBTK NA 95% Human Human +DTXSID5047299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047299 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047299 Vd NA 0.5949 L/kg 1compartment NA NA Rat Human DTXSID5047299 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047299 TK.Half.Life NA 1.058 hours 1compartment NA NA Rat Human -DTXSID5047299 Css NA 0.05486 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047299 Css NA 0.5049 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047299 Css NA 0.03651 mg/L PBTK NA 50% Rat Human -DTXSID5047299 Css NA 0.2985 mg/L PBTK NA 95% Rat Human +DTXSID5047299 TK.Half.Life NA 0.6129 hours 1compartment NA NA Rat Human +DTXSID5047299 Css NA 0.01628 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047299 Css NA 0.0868 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047299 Css NA 0.01082 mg/L PBTK NA 50% Rat Human +DTXSID5047299 Css NA 0.05476 mg/L PBTK NA 95% Rat Human DTXSID5047320 Clint 4.65 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5047320 Fup 0.015 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5047320 Vd NA 3.062 L/kg 1compartment NA NA Human Human -DTXSID5047320 Days.Css NA 77 Days PBTK NA NA Human Human -DTXSID5047320 TK.Half.Life NA 344.7 hours 1compartment NA NA Human Human -DTXSID5047320 Css NA 13.94 mg/L 3compartmentss NA 50% Human Human -DTXSID5047320 Css NA 85.79 mg/L 3compartmentss NA 95% Human Human -DTXSID5047320 Css NA 9.631 mg/L PBTK NA 50% Human Human -DTXSID5047320 Css NA 58.01 mg/L PBTK NA 95% Human Human +DTXSID5047320 Vd NA 8.354 L/kg 1compartment NA NA Human Human +DTXSID5047320 Days.Css NA 284 Days PBTK NA NA Human Human +DTXSID5047320 TK.Half.Life NA 1146 hours 1compartment NA NA Human Human +DTXSID5047320 Css NA 9.23 mg/L 3compartmentss NA 50% Human Human +DTXSID5047320 Css NA 56.3 mg/L 3compartmentss NA 95% Human Human +DTXSID5047320 Css NA 9.826 mg/L PBTK NA 50% Human Human +DTXSID5047320 Css NA 57.67 mg/L PBTK NA 95% Human Human DTXSID5047320 Clint 4.65 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5047320 Fup 0.015 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5047320 Vd NA 2.295 L/kg 1compartment NA NA Rat Human -DTXSID5047320 Days.Css NA 41 Days PBTK NA NA Rat Human -DTXSID5047320 TK.Half.Life NA 48.51 hours 1compartment NA NA Rat Human -DTXSID5047320 Css NA 7.741 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047320 Css NA 39.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047320 Css NA 5.123 mg/L PBTK NA 50% Rat Human -DTXSID5047320 Css NA 24.9 mg/L PBTK NA 95% Rat Human -DTXSID5047322 Clint NA 50.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047322 Fup NA 0.0072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047322 Vd NA 1.262 L/kg 1compartment NA NA Human Human -DTXSID5047322 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047322 TK.Half.Life NA 10.98 hours 1compartment NA NA Human Human -DTXSID5047322 Css NA 1.433 mg/L 3compartmentss NA 50% Human Human -DTXSID5047322 Css NA 12.61 mg/L 3compartmentss NA 95% Human Human -DTXSID5047322 Css NA 0.879 mg/L PBTK NA 50% Human Human -DTXSID5047322 Css NA 7.54 mg/L PBTK NA 95% Human Human -DTXSID5047322 Clint NA 50.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047322 Fup NA 0.0072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047322 Vd NA 0.9278 L/kg 1compartment NA NA Rat Human -DTXSID5047322 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047322 TK.Half.Life NA 4.507 hours 1compartment NA NA Rat Human -DTXSID5047322 Css NA 0.8094 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047322 Css NA 6.538 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047322 Css NA 0.4624 mg/L PBTK NA 50% Rat Human -DTXSID5047322 Css NA 3.596 mg/L PBTK NA 95% Rat Human -DTXSID5047324 Clint NA 61.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047324 Fup NA 0.0336 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047324 Vd NA 0.4548 L/kg 1compartment NA NA Human Human +DTXSID5047320 Vd NA 6.525 L/kg 1compartment NA NA Rat Human +DTXSID5047320 Days.Css NA 163 Days PBTK NA NA Rat Human +DTXSID5047320 TK.Half.Life NA 154.7 hours 1compartment NA NA Rat Human +DTXSID5047320 Css NA 0.4396 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047320 Css NA 2.809 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047320 Css NA 0.4778 mg/L PBTK NA 50% Rat Human +DTXSID5047320 Css NA 2.868 mg/L PBTK NA 95% Rat Human +DTXSID5047322 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047322 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047322 Vd NA 2.952 L/kg 1compartment NA NA Human Human +DTXSID5047322 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID5047322 TK.Half.Life NA 51.8 hours 1compartment NA NA Human Human +DTXSID5047322 Css NA 2.199 mg/L 3compartmentss NA 50% Human Human +DTXSID5047322 Css NA 14.7 mg/L 3compartmentss NA 95% Human Human +DTXSID5047322 Css NA 1.504 mg/L PBTK NA 50% Human Human +DTXSID5047322 Css NA 9.693 mg/L PBTK NA 95% Human Human +DTXSID5047322 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047322 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047322 Vd NA 2.211 L/kg 1compartment NA NA Rat Human +DTXSID5047322 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID5047322 TK.Half.Life NA 8.742 hours 1compartment NA NA Rat Human +DTXSID5047322 Css NA 0.2845 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047322 Css NA 1.535 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047322 Css NA 0.1923 mg/L PBTK NA 50% Rat Human +DTXSID5047322 Css NA 1.015 mg/L PBTK NA 95% Rat Human +DTXSID5047324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047324 Fup 0.0626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047324 Vd NA 0.734 L/kg 1compartment NA NA Human Human DTXSID5047324 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047324 TK.Half.Life NA 1.232 hours 1compartment NA NA Human Human -DTXSID5047324 Css NA 0.3524 mg/L 3compartmentss NA 50% Human Human -DTXSID5047324 Css NA 2.923 mg/L 3compartmentss NA 95% Human Human -DTXSID5047324 Css NA 0.2114 mg/L PBTK NA 50% Human Human -DTXSID5047324 Css NA 1.695 mg/L PBTK NA 95% Human Human -DTXSID5047324 Clint NA 61.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047324 Fup NA 0.0336 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047324 Vd NA 0.3703 L/kg 1compartment NA NA Rat Human +DTXSID5047324 TK.Half.Life NA 2.649 hours 1compartment NA NA Human Human +DTXSID5047324 Css NA 0.4638 mg/L 3compartmentss NA 50% Human Human +DTXSID5047324 Css NA 3.633 mg/L 3compartmentss NA 95% Human Human +DTXSID5047324 Css NA 0.2865 mg/L PBTK NA 50% Human Human +DTXSID5047324 Css NA 2.206 mg/L PBTK NA 95% Human Human +DTXSID5047324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047324 Fup 0.0626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047324 Vd NA 0.5809 L/kg 1compartment NA NA Rat Human DTXSID5047324 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047324 TK.Half.Life NA 0.597 hours 1compartment NA NA Rat Human -DTXSID5047324 Css NA 0.2015 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047324 Css NA 1.326 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047324 Css NA 0.1129 mg/L PBTK NA 50% Rat Human -DTXSID5047324 Css NA 0.7378 mg/L PBTK NA 95% Rat Human -DTXSID5047328 Clint NA 0.03459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047328 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047328 Vd NA 0.4436 L/kg 1compartment NA NA Human Human -DTXSID5047328 Days.Css NA 168 Days PBTK NA NA Human Human -DTXSID5047328 TK.Half.Life NA 613.9 hours 1compartment NA NA Human Human -DTXSID5047328 Css NA 233 mg/L 3compartmentss NA 50% Human Human -DTXSID5047328 Css NA 1364 mg/L 3compartmentss NA 95% Human Human -DTXSID5047328 Css NA 137.4 mg/L PBTK NA 50% Human Human -DTXSID5047328 Css NA 801 mg/L PBTK NA 95% Human Human -DTXSID5047328 Clint NA 0.03459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047328 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047328 Vd NA 0.3387 L/kg 1compartment NA NA Rat Human -DTXSID5047328 Days.Css NA 40 Days PBTK NA NA Rat Human -DTXSID5047328 TK.Half.Life NA 161.6 hours 1compartment NA NA Rat Human -DTXSID5047328 Css NA 69.29 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047328 Css NA 374.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047328 Css NA 37.89 mg/L PBTK NA 50% Rat Human -DTXSID5047328 Css NA 202.8 mg/L PBTK NA 95% Rat Human -DTXSID5047372 Clint NA 50.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047372 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047372 Vd NA 0.7369 L/kg 1compartment NA NA Human Human -DTXSID5047372 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5047372 TK.Half.Life NA 11.01 hours 1compartment NA NA Human Human -DTXSID5047372 Css NA 2.694 mg/L 3compartmentss NA 50% Human Human -DTXSID5047372 Css NA 21.72 mg/L 3compartmentss NA 95% Human Human -DTXSID5047372 Css NA 1.596 mg/L PBTK NA 50% Human Human -DTXSID5047372 Css NA 12.75 mg/L PBTK NA 95% Human Human -DTXSID5047372 Clint NA 50.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047372 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047372 Vd NA 0.5436 L/kg 1compartment NA NA Rat Human +DTXSID5047324 TK.Half.Life NA 1.241 hours 1compartment NA NA Rat Human +DTXSID5047324 Css NA 0.06022 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047324 Css NA 0.3642 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047324 Css NA 0.03638 mg/L PBTK NA 50% Rat Human +DTXSID5047324 Css NA 0.212 mg/L PBTK NA 95% Rat Human +DTXSID5047328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047328 Fup 0.0367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047328 Vd NA 1.806 L/kg 1compartment NA NA Human Human +DTXSID5047328 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047328 TK.Half.Life NA 11.11 hours 1compartment NA NA Human Human +DTXSID5047328 Css NA 0.8993 mg/L 3compartmentss NA 50% Human Human +DTXSID5047328 Css NA 6.795 mg/L 3compartmentss NA 95% Human Human +DTXSID5047328 Css NA 0.5772 mg/L PBTK NA 50% Human Human +DTXSID5047328 Css NA 4.131 mg/L PBTK NA 95% Human Human +DTXSID5047328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047328 Fup 0.0367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047328 Vd NA 1.348 L/kg 1compartment NA NA Rat Human +DTXSID5047328 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047328 TK.Half.Life NA 3.883 hours 1compartment NA NA Rat Human +DTXSID5047328 Css NA 0.1182 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047328 Css NA 0.6807 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047328 Css NA 0.0737 mg/L PBTK NA 50% Rat Human +DTXSID5047328 Css NA 0.4124 mg/L PBTK NA 95% Rat Human +DTXSID5047372 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047372 Fup 0.0346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047372 Vd NA 0.3368 L/kg 1compartment NA NA Human Human +DTXSID5047372 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047372 TK.Half.Life NA 1.954 hours 1compartment NA NA Human Human +DTXSID5047372 Css NA 0.8148 mg/L 3compartmentss NA 50% Human Human +DTXSID5047372 Css NA 6.525 mg/L 3compartmentss NA 95% Human Human +DTXSID5047372 Css NA 0.4888 mg/L PBTK NA 50% Human Human +DTXSID5047372 Css NA 3.828 mg/L PBTK NA 95% Human Human +DTXSID5047372 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047372 Fup 0.0346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047372 Vd NA 0.289 L/kg 1compartment NA NA Rat Human DTXSID5047372 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047372 TK.Half.Life NA 5.15 hours 1compartment NA NA Rat Human -DTXSID5047372 Css NA 1.536 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047372 Css NA 10.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047372 Css NA 0.8511 mg/L PBTK NA 50% Rat Human -DTXSID5047372 Css NA 5.542 mg/L PBTK NA 95% Rat Human -DTXSID5047376 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047376 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047376 Vd NA 0.1913 L/kg 1compartment NA NA Human Human -DTXSID5047376 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID5047376 TK.Half.Life NA 84.19 hours 1compartment NA NA Human Human -DTXSID5047376 Css NA 75.54 mg/L 3compartmentss NA 50% Human Human -DTXSID5047376 Css NA 474 mg/L 3compartmentss NA 95% Human Human -DTXSID5047376 Css NA 44.4 mg/L PBTK NA 50% Human Human -DTXSID5047376 Css NA 275.7 mg/L PBTK NA 95% Human Human -DTXSID5047376 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047376 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047376 Vd NA 0.1885 L/kg 1compartment NA NA Rat Human -DTXSID5047376 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5047376 TK.Half.Life NA 28.28 hours 1compartment NA NA Rat Human -DTXSID5047376 Css NA 21.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047376 Css NA 115 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047376 Css NA 11.81 mg/L PBTK NA 50% Rat Human -DTXSID5047376 Css NA 62.25 mg/L PBTK NA 95% Rat Human -DTXSID5047451 Clint NA 3.349 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047451 Fup NA 0.03 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047451 Vd NA 0.2749 L/kg 1compartment NA NA Human Human +DTXSID5047372 TK.Half.Life NA 1.068 hours 1compartment NA NA Rat Human +DTXSID5047372 Css NA 0.04067 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047372 Css NA 0.3443 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047372 Css NA 0.02334 mg/L PBTK NA 50% Rat Human +DTXSID5047372 Css NA 0.196 mg/L PBTK NA 95% Rat Human +DTXSID5047374 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047374 Fup 0.0388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047374 Vd NA 1.293 L/kg 1compartment NA NA Human Human +DTXSID5047374 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047374 TK.Half.Life NA 7.063 hours 1compartment NA NA Human Human +DTXSID5047374 Css NA 0.7963 mg/L 3compartmentss NA 50% Human Human +DTXSID5047374 Css NA 6.849 mg/L 3compartmentss NA 95% Human Human +DTXSID5047374 Css NA 0.4996 mg/L PBTK NA 50% Human Human +DTXSID5047374 Css NA 4.156 mg/L PBTK NA 95% Human Human +DTXSID5047374 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047374 Fup 0.0388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047374 Vd NA 0.9704 L/kg 1compartment NA NA Rat Human +DTXSID5047374 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047374 TK.Half.Life NA 2.882 hours 1compartment NA NA Rat Human +DTXSID5047374 Css NA 0.1042 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047374 Css NA 0.7411 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047374 Css NA 0.06357 mg/L PBTK NA 50% Rat Human +DTXSID5047374 Css NA 0.4349 mg/L PBTK NA 95% Rat Human +DTXSID5047376 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047376 Fup 0.0757 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047376 Vd NA 0.3223 L/kg 1compartment NA NA Human Human +DTXSID5047376 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047376 TK.Half.Life NA 1.021 hours 1compartment NA NA Human Human +DTXSID5047376 Css NA 0.3414 mg/L 3compartmentss NA 50% Human Human +DTXSID5047376 Css NA 2.711 mg/L 3compartmentss NA 95% Human Human +DTXSID5047376 Css NA 0.212 mg/L PBTK NA 50% Human Human +DTXSID5047376 Css NA 1.624 mg/L PBTK NA 95% Human Human +DTXSID5047376 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047376 Fup 0.0757 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047376 Vd NA 0.3186 L/kg 1compartment NA NA Rat Human +DTXSID5047376 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047376 TK.Half.Life NA 0.6156 hours 1compartment NA NA Rat Human +DTXSID5047376 Css NA 0.01685 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047376 Css NA 0.1434 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047376 Css NA 0.01006 mg/L PBTK NA 50% Rat Human +DTXSID5047376 Css NA 0.08247 mg/L PBTK NA 95% Rat Human +DTXSID5047451 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047451 Fup 0.0886 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047451 Vd NA 0.294 L/kg 1compartment NA NA Human Human DTXSID5047451 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047451 TK.Half.Life NA 9.246 hours 1compartment NA NA Human Human -DTXSID5047451 Css NA 5.968 mg/L 3compartmentss NA 50% Human Human -DTXSID5047451 Css NA 45.13 mg/L 3compartmentss NA 95% Human Human -DTXSID5047451 Css NA 3.622 mg/L PBTK NA 50% Human Human -DTXSID5047451 Css NA 26.57 mg/L PBTK NA 95% Human Human -DTXSID5047451 Clint NA 3.349 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047451 Fup NA 0.03 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047451 Vd NA 0.2682 L/kg 1compartment NA NA Rat Human +DTXSID5047451 TK.Half.Life NA 0.8358 hours 1compartment NA NA Human Human +DTXSID5047451 Css NA 0.1738 mg/L 3compartmentss NA 50% Human Human +DTXSID5047451 Css NA 1.586 mg/L 3compartmentss NA 95% Human Human +DTXSID5047451 Css NA 0.1066 mg/L PBTK NA 50% Human Human +DTXSID5047451 Css NA 0.9324 mg/L PBTK NA 95% Human Human +DTXSID5047451 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047451 Fup 0.0886 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047451 Vd NA 0.2876 L/kg 1compartment NA NA Rat Human DTXSID5047451 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047451 TK.Half.Life NA 5.398 hours 1compartment NA NA Rat Human -DTXSID5047451 Css NA 3.016 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047451 Css NA 18.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047451 Css NA 1.704 mg/L PBTK NA 50% Rat Human -DTXSID5047451 Css NA 10.06 mg/L PBTK NA 95% Rat Human -DTXSID5047459 Clint NA 0.05249 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047459 Fup NA 0.2638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047459 Vd NA 0.3287 L/kg 1compartment NA NA Human Human +DTXSID5047451 TK.Half.Life NA 0.4906 hours 1compartment NA NA Rat Human +DTXSID5047451 Css NA 0.001874 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047451 Css NA 0.01426 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047451 Css NA 0.001079 mg/L PBTK NA 50% Rat Human +DTXSID5047451 Css NA 0.007964 mg/L PBTK NA 95% Rat Human +DTXSID5047453 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047453 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047453 Vd NA 1.57 L/kg 1compartment NA NA Human Human +DTXSID5047453 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047453 TK.Half.Life NA 1.704 hours 1compartment NA NA Human Human +DTXSID5047453 Css NA 0.04717 mg/L 3compartmentss NA 50% Human Human +DTXSID5047453 Css NA 0.3863 mg/L 3compartmentss NA 95% Human Human +DTXSID5047453 Css NA 0.03928 mg/L PBTK NA 50% Human Human +DTXSID5047453 Css NA 0.2792 mg/L PBTK NA 95% Human Human +DTXSID5047453 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047453 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047453 Vd NA 1.424 L/kg 1compartment NA NA Rat Human +DTXSID5047453 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047453 TK.Half.Life NA 0.7803 hours 1compartment NA NA Rat Human +DTXSID5047453 Css NA 0.00582 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047453 Css NA 0.03641 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047453 Css NA 0.004898 mg/L PBTK NA 50% Rat Human +DTXSID5047453 Css NA 0.02633 mg/L PBTK NA 95% Rat Human +DTXSID5047459 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047459 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047459 Vd NA 0.5825 L/kg 1compartment NA NA Human Human DTXSID5047459 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047459 TK.Half.Life NA 7.421 hours 1compartment NA NA Human Human -DTXSID5047459 Css NA 2.748 mg/L 3compartmentss NA 50% Human Human -DTXSID5047459 Css NA 10.61 mg/L 3compartmentss NA 95% Human Human -DTXSID5047459 Css NA 1.811 mg/L PBTK NA 50% Human Human -DTXSID5047459 Css NA 6.523 mg/L PBTK NA 95% Human Human -DTXSID5047459 Clint NA 0.05249 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047459 Fup NA 0.2638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047459 Vd NA 0.3311 L/kg 1compartment NA NA Rat Human +DTXSID5047459 TK.Half.Life NA 9.42 hours 1compartment NA NA Human Human +DTXSID5047459 Css NA 1.716 mg/L 3compartmentss NA 50% Human Human +DTXSID5047459 Css NA 7.592 mg/L 3compartmentss NA 95% Human Human +DTXSID5047459 Css NA 1.298 mg/L PBTK NA 50% Human Human +DTXSID5047459 Css NA 4.895 mg/L PBTK NA 95% Human Human +DTXSID5047459 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047459 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047459 Vd NA 0.5925 L/kg 1compartment NA NA Rat Human DTXSID5047459 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047459 TK.Half.Life NA 2.656 hours 1compartment NA NA Rat Human -DTXSID5047459 Css NA 0.8053 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047459 Css NA 2.599 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047459 Css NA 0.5017 mg/L PBTK NA 50% Rat Human -DTXSID5047459 Css NA 1.478 mg/L PBTK NA 95% Rat Human -DTXSID5047530 Clint NA 53.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047530 Fup NA 0.0586 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047530 Vd NA 1.523 L/kg 1compartment NA NA Human Human +DTXSID5047459 TK.Half.Life NA 3.265 hours 1compartment NA NA Rat Human +DTXSID5047459 Css NA 0.109 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047459 Css NA 0.4258 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047459 Css NA 0.0818 mg/L PBTK NA 50% Rat Human +DTXSID5047459 Css NA 0.2634 mg/L PBTK NA 95% Rat Human +DTXSID5047530 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047530 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047530 Vd NA 2.056 L/kg 1compartment NA NA Human Human DTXSID5047530 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047530 TK.Half.Life NA 3.32 hours 1compartment NA NA Human Human -DTXSID5047530 Css NA 0.2186 mg/L 3compartmentss NA 50% Human Human -DTXSID5047530 Css NA 1.675 mg/L 3compartmentss NA 95% Human Human -DTXSID5047530 Css NA 0.1422 mg/L PBTK NA 50% Human Human -DTXSID5047530 Css NA 1.046 mg/L PBTK NA 95% Human Human -DTXSID5047530 Clint NA 53.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047530 Fup NA 0.0586 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047530 Vd NA 1.182 L/kg 1compartment NA NA Rat Human +DTXSID5047530 TK.Half.Life NA 4.214 hours 1compartment NA NA Human Human +DTXSID5047530 Css NA 0.1533 mg/L 3compartmentss NA 50% Human Human +DTXSID5047530 Css NA 1.055 mg/L 3compartmentss NA 95% Human Human +DTXSID5047530 Css NA 0.1124 mg/L PBTK NA 50% Human Human +DTXSID5047530 Css NA 0.74 mg/L PBTK NA 95% Human Human +DTXSID5047530 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047530 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047530 Vd NA 1.646 L/kg 1compartment NA NA Rat Human DTXSID5047530 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047530 TK.Half.Life NA 1.305 hours 1compartment NA NA Rat Human -DTXSID5047530 Css NA 0.1258 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047530 Css NA 0.7904 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047530 Css NA 0.07711 mg/L PBTK NA 50% Rat Human -DTXSID5047530 Css NA 0.4644 mg/L PBTK NA 95% Rat Human -DTXSID5047538 Clint NA 65.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047538 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047538 Vd NA 2.309 L/kg 1compartment NA NA Human Human -DTXSID5047538 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047538 TK.Half.Life NA 10.39 hours 1compartment NA NA Human Human -DTXSID5047538 Css NA 0.5761 mg/L 3compartmentss NA 50% Human Human -DTXSID5047538 Css NA 4.616 mg/L 3compartmentss NA 95% Human Human -DTXSID5047538 Css NA 0.3783 mg/L PBTK NA 50% Human Human -DTXSID5047538 Css NA 2.851 mg/L PBTK NA 95% Human Human -DTXSID5047538 Clint NA 65.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047538 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047538 Vd NA 1.72 L/kg 1compartment NA NA Rat Human -DTXSID5047538 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047538 TK.Half.Life NA 2.962 hours 1compartment NA NA Rat Human -DTXSID5047538 Css NA 0.3238 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047538 Css NA 2.239 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047538 Css NA 0.2001 mg/L PBTK NA 50% Rat Human -DTXSID5047538 Css NA 1.313 mg/L PBTK NA 95% Rat Human -DTXSID5047584 Clint NA 40.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047584 Fup NA 0.039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047584 Vd NA 2.176 L/kg 1compartment NA NA Human Human -DTXSID5047584 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047584 TK.Half.Life NA 8.951 hours 1compartment NA NA Human Human -DTXSID5047584 Css NA 0.528 mg/L 3compartmentss NA 50% Human Human -DTXSID5047584 Css NA 4.038 mg/L 3compartmentss NA 95% Human Human -DTXSID5047584 Css NA 0.3466 mg/L PBTK NA 50% Human Human -DTXSID5047584 Css NA 2.53 mg/L PBTK NA 95% Human Human -DTXSID5047584 Clint NA 40.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047584 Fup NA 0.039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047584 Vd NA 1.627 L/kg 1compartment NA NA Rat Human -DTXSID5047584 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047584 TK.Half.Life NA 2.729 hours 1compartment NA NA Rat Human -DTXSID5047584 Css NA 0.2938 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047584 Css NA 1.877 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047584 Css NA 0.1816 mg/L PBTK NA 50% Rat Human -DTXSID5047584 Css NA 1.116 mg/L PBTK NA 95% Rat Human -DTXSID5047611 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047611 Fup NA 0.7039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047611 Vd NA 1.521 L/kg 1compartment NA NA Human Human -DTXSID5047611 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5047611 TK.Half.Life NA 16.41 hours 1compartment NA NA Human Human -DTXSID5047611 Css NA 1.088 mg/L 3compartmentss NA 50% Human Human -DTXSID5047611 Css NA 7.041 mg/L 3compartmentss NA 95% Human Human -DTXSID5047611 Css NA 0.9814 mg/L PBTK NA 50% Human Human -DTXSID5047611 Css NA 4.664 mg/L PBTK NA 95% Human Human -DTXSID5047611 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047611 Fup NA 0.7039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047611 Vd NA 1.331 L/kg 1compartment NA NA Rat Human +DTXSID5047530 TK.Half.Life NA 1.549 hours 1compartment NA NA Rat Human +DTXSID5047530 Css NA 0.01949 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047530 Css NA 0.1 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047530 Css NA 0.01444 mg/L PBTK NA 50% Rat Human +DTXSID5047530 Css NA 0.06843 mg/L PBTK NA 95% Rat Human +DTXSID5047538 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047538 Fup 0.00705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047538 Vd NA 1.954 L/kg 1compartment NA NA Human Human +DTXSID5047538 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5047538 TK.Half.Life NA 37.03 hours 1compartment NA NA Human Human +DTXSID5047538 Css NA 2.973 mg/L 3compartmentss NA 50% Human Human +DTXSID5047538 Css NA 25.6 mg/L 3compartmentss NA 95% Human Human +DTXSID5047538 Css NA 1.881 mg/L PBTK NA 50% Human Human +DTXSID5047538 Css NA 15.69 mg/L PBTK NA 95% Human Human +DTXSID5047538 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047538 Fup 0.00705 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047538 Vd NA 1.445 L/kg 1compartment NA NA Rat Human +DTXSID5047538 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5047538 TK.Half.Life NA 12.09 hours 1compartment NA NA Rat Human +DTXSID5047538 Css NA 0.3869 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047538 Css NA 2.651 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047538 Css NA 0.2387 mg/L PBTK NA 50% Rat Human +DTXSID5047538 Css NA 1.552 mg/L PBTK NA 95% Rat Human +DTXSID5047584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047584 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047584 Vd NA 2.589 L/kg 1compartment NA NA Human Human +DTXSID5047584 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5047584 TK.Half.Life NA 29.74 hours 1compartment NA NA Human Human +DTXSID5047584 Css NA 1.548 mg/L 3compartmentss NA 50% Human Human +DTXSID5047584 Css NA 11 mg/L 3compartmentss NA 95% Human Human +DTXSID5047584 Css NA 1.034 mg/L PBTK NA 50% Human Human +DTXSID5047584 Css NA 6.922 mg/L PBTK NA 95% Human Human +DTXSID5047584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047584 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047584 Vd NA 1.935 L/kg 1compartment NA NA Rat Human +DTXSID5047584 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5047584 TK.Half.Life NA 6.953 hours 1compartment NA NA Rat Human +DTXSID5047584 Css NA 0.1992 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047584 Css NA 1.181 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047584 Css NA 0.1313 mg/L PBTK NA 50% Rat Human +DTXSID5047584 Css NA 0.7384 mg/L PBTK NA 95% Rat Human +DTXSID5047611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047611 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047611 Vd NA 0.9704 L/kg 1compartment NA NA Human Human +DTXSID5047611 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047611 TK.Half.Life NA 0.8955 hours 1compartment NA NA Human Human +DTXSID5047611 Css NA 0.03463 mg/L 3compartmentss NA 50% Human Human +DTXSID5047611 Css NA 0.3739 mg/L 3compartmentss NA 95% Human Human +DTXSID5047611 Css NA 0.02828 mg/L PBTK NA 50% Human Human +DTXSID5047611 Css NA 0.2551 mg/L PBTK NA 95% Human Human +DTXSID5047611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047611 Fup 0.56 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047611 Vd NA 0.905 L/kg 1compartment NA NA Rat Human DTXSID5047611 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047611 TK.Half.Life NA 4.34 hours 1compartment NA NA Rat Human -DTXSID5047611 Css NA 0.2849 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047611 Css NA 1.783 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047611 Css NA 0.2497 mg/L PBTK NA 50% Rat Human -DTXSID5047611 Css NA 1.099 mg/L PBTK NA 95% Rat Human -DTXSID5047661 Clint NA 4.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047661 Fup NA 0.7403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047661 Vd NA 2.24 L/kg 1compartment NA NA Human Human +DTXSID5047611 TK.Half.Life NA 0.4151 hours 1compartment NA NA Rat Human +DTXSID5047611 Css NA 0.004222 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047611 Css NA 0.04013 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047611 Css NA 0.003476 mg/L PBTK NA 50% Rat Human +DTXSID5047611 Css NA 0.02678 mg/L PBTK NA 95% Rat Human +DTXSID5047661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047661 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047661 Vd NA 1.508 L/kg 1compartment NA NA Human Human DTXSID5047661 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047661 TK.Half.Life NA 4.646 hours 1compartment NA NA Human Human -DTXSID5047661 Css NA 0.1677 mg/L 3compartmentss NA 50% Human Human -DTXSID5047661 Css NA 1.191 mg/L 3compartmentss NA 95% Human Human -DTXSID5047661 Css NA 0.1496 mg/L PBTK NA 50% Human Human -DTXSID5047661 Css NA 0.8865 mg/L PBTK NA 95% Human Human -DTXSID5047661 Clint NA 4.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047661 Fup NA 0.7403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047661 Vd NA 1.832 L/kg 1compartment NA NA Rat Human +DTXSID5047661 TK.Half.Life NA 2.305 hours 1compartment NA NA Human Human +DTXSID5047661 Css NA 0.0944 mg/L 3compartmentss NA 50% Human Human +DTXSID5047661 Css NA 0.6489 mg/L 3compartmentss NA 95% Human Human +DTXSID5047661 Css NA 0.06959 mg/L PBTK NA 50% Human Human +DTXSID5047661 Css NA 0.4488 mg/L PBTK NA 95% Human Human +DTXSID5047661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047661 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047661 Vd NA 1.205 L/kg 1compartment NA NA Rat Human DTXSID5047661 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047661 TK.Half.Life NA 1.563 hours 1compartment NA NA Rat Human -DTXSID5047661 Css NA 0.0811 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047661 Css NA 0.4892 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047661 Css NA 0.07104 mg/L PBTK NA 50% Rat Human -DTXSID5047661 Css NA 0.3258 mg/L PBTK NA 95% Rat Human -DTXSID5047665 Clint NA 4.965 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047665 Fup NA 0.261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047665 Vd NA 3.061 L/kg 1compartment NA NA Human Human -DTXSID5047665 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID5047665 TK.Half.Life NA 79.76 hours 1compartment NA NA Human Human -DTXSID5047665 Css NA 3.068 mg/L 3compartmentss NA 50% Human Human -DTXSID5047665 Css NA 16.14 mg/L 3compartmentss NA 95% Human Human -DTXSID5047665 Css NA 2.17 mg/L PBTK NA 50% Human Human -DTXSID5047665 Css NA 11.06 mg/L PBTK NA 95% Human Human -DTXSID5047665 Clint NA 4.965 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047665 Fup NA 0.261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047665 Vd NA 2.306 L/kg 1compartment NA NA Rat Human -DTXSID5047665 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID5047665 TK.Half.Life NA 11.47 hours 1compartment NA NA Rat Human -DTXSID5047665 Css NA 1.614 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047665 Css NA 6.061 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047665 Css NA 1.099 mg/L PBTK NA 50% Rat Human -DTXSID5047665 Css NA 4.039 mg/L PBTK NA 95% Rat Human -DTXSID5047790 Clint NA 24.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047790 Fup NA 0.1127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047790 Vd NA 2.298 L/kg 1compartment NA NA Human Human +DTXSID5047661 TK.Half.Life NA 0.9064 hours 1compartment NA NA Rat Human +DTXSID5047661 Css NA 0.01174 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047661 Css NA 0.06152 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047661 Css NA 0.008657 mg/L PBTK NA 50% Rat Human +DTXSID5047661 Css NA 0.04296 mg/L PBTK NA 95% Rat Human +DTXSID5047790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047790 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047790 Vd NA 1.035 L/kg 1compartment NA NA Human Human DTXSID5047790 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047790 TK.Half.Life NA 3.767 hours 1compartment NA NA Human Human -DTXSID5047790 Css NA 0.1264 mg/L 3compartmentss NA 50% Human Human -DTXSID5047790 Css NA 1.179 mg/L 3compartmentss NA 95% Human Human -DTXSID5047790 Css NA 0.1096 mg/L PBTK NA 50% Human Human -DTXSID5047790 Css NA 0.8619 mg/L PBTK NA 95% Human Human -DTXSID5047790 Clint NA 24.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047790 Fup NA 0.1127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047790 Vd NA 2.29 L/kg 1compartment NA NA Rat Human +DTXSID5047790 TK.Half.Life NA 1.424 hours 1compartment NA NA Human Human +DTXSID5047790 Css NA 0.07478 mg/L 3compartmentss NA 50% Human Human +DTXSID5047790 Css NA 0.5676 mg/L 3compartmentss NA 95% Human Human +DTXSID5047790 Css NA 0.05666 mg/L PBTK NA 50% Human Human +DTXSID5047790 Css NA 0.3899 mg/L PBTK NA 95% Human Human +DTXSID5047790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047790 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047790 Vd NA 1.036 L/kg 1compartment NA NA Rat Human DTXSID5047790 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047790 TK.Half.Life NA 2.185 hours 1compartment NA NA Rat Human -DTXSID5047790 Css NA 0.07104 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047790 Css NA 0.5243 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047790 Css NA 0.05838 mg/L PBTK NA 50% Rat Human -DTXSID5047790 Css NA 0.3555 mg/L PBTK NA 95% Rat Human -DTXSID5047796 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047796 Fup NA 0.4888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047796 Vd NA 0.6135 L/kg 1compartment NA NA Human Human -DTXSID5047796 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047796 TK.Half.Life NA 8.148 hours 1compartment NA NA Human Human -DTXSID5047796 Css NA 1.464 mg/L 3compartmentss NA 50% Human Human -DTXSID5047796 Css NA 7.33 mg/L 3compartmentss NA 95% Human Human -DTXSID5047796 Css NA 1.122 mg/L PBTK NA 50% Human Human -DTXSID5047796 Css NA 4.636 mg/L PBTK NA 95% Human Human -DTXSID5047796 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047796 Fup NA 0.4888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047796 Vd NA 0.6196 L/kg 1compartment NA NA Rat Human -DTXSID5047796 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047796 TK.Half.Life NA 2.798 hours 1compartment NA NA Rat Human -DTXSID5047796 Css NA 0.3996 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047796 Css NA 1.753 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047796 Css NA 0.2924 mg/L PBTK NA 50% Rat Human -DTXSID5047796 Css NA 1.041 mg/L PBTK NA 95% Rat Human -DTXSID5047825 Clint NA 49.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047825 Fup NA 0.0406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047825 Vd NA 2.988 L/kg 1compartment NA NA Human Human -DTXSID5047825 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5047825 TK.Half.Life NA 16.93 hours 1compartment NA NA Human Human -DTXSID5047825 Css NA 0.6583 mg/L 3compartmentss NA 50% Human Human -DTXSID5047825 Css NA 4.405 mg/L 3compartmentss NA 95% Human Human -DTXSID5047825 Css NA 0.4595 mg/L PBTK NA 50% Human Human -DTXSID5047825 Css NA 2.984 mg/L PBTK NA 95% Human Human -DTXSID5047825 Clint NA 49.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047825 Fup NA 0.0406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047825 Vd NA 2.281 L/kg 1compartment NA NA Rat Human +DTXSID5047790 TK.Half.Life NA 0.7801 hours 1compartment NA NA Rat Human +DTXSID5047790 Css NA 0.009611 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047790 Css NA 0.05424 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047790 Css NA 0.007208 mg/L PBTK NA 50% Rat Human +DTXSID5047790 Css NA 0.03725 mg/L PBTK NA 95% Rat Human +DTXSID5047825 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047825 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047825 Vd NA 0.9598 L/kg 1compartment NA NA Human Human +DTXSID5047825 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5047825 TK.Half.Life NA 24.92 hours 1compartment NA NA Human Human +DTXSID5047825 Css NA 1.554 mg/L 3compartmentss NA 50% Human Human +DTXSID5047825 Css NA 6.382 mg/L 3compartmentss NA 95% Human Human +DTXSID5047825 Css NA 1.146 mg/L PBTK NA 50% Human Human +DTXSID5047825 Css NA 4.145 mg/L PBTK NA 95% Human Human +DTXSID5047825 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047825 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047825 Vd NA 0.821 L/kg 1compartment NA NA Rat Human DTXSID5047825 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047825 TK.Half.Life NA 3.448 hours 1compartment NA NA Rat Human -DTXSID5047825 Css NA 0.3718 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047825 Css NA 2.022 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047825 Css NA 0.247 mg/L PBTK NA 50% Rat Human -DTXSID5047825 Css NA 1.272 mg/L PBTK NA 95% Rat Human -DTXSID5047829 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047829 Fup NA 0.9947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047829 Vd NA 0.6757 L/kg 1compartment NA NA Human Human -DTXSID5047829 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047829 TK.Half.Life NA 4.393 hours 1compartment NA NA Human Human -DTXSID5047829 Css NA 0.879 mg/L 3compartmentss NA 50% Human Human -DTXSID5047829 Css NA 5.159 mg/L 3compartmentss NA 95% Human Human -DTXSID5047829 Css NA 0.7176 mg/L PBTK NA 50% Human Human -DTXSID5047829 Css NA 3.335 mg/L PBTK NA 95% Human Human -DTXSID5047829 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047829 Fup NA 0.9947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047829 Vd NA 0.7323 L/kg 1compartment NA NA Rat Human -DTXSID5047829 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047829 TK.Half.Life NA 1.623 hours 1compartment NA NA Rat Human -DTXSID5047829 Css NA 0.2252 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047829 Css NA 1.238 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047829 Css NA 0.1787 mg/L PBTK NA 50% Rat Human -DTXSID5047829 Css NA 0.7437 mg/L PBTK NA 95% Rat Human -DTXSID5047879 Clint NA 22.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047879 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047879 Vd NA 2.249 L/kg 1compartment NA NA Human Human -DTXSID5047879 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047879 TK.Half.Life NA 11.72 hours 1compartment NA NA Human Human -DTXSID5047879 Css NA 0.66 mg/L 3compartmentss NA 50% Human Human -DTXSID5047879 Css NA 4.432 mg/L 3compartmentss NA 95% Human Human -DTXSID5047879 Css NA 0.4403 mg/L PBTK NA 50% Human Human -DTXSID5047879 Css NA 2.839 mg/L PBTK NA 95% Human Human -DTXSID5047879 Clint NA 22.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047879 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047879 Vd NA 1.687 L/kg 1compartment NA NA Rat Human +DTXSID5047825 TK.Half.Life NA 6.836 hours 1compartment NA NA Rat Human +DTXSID5047825 Css NA 0.008381 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047825 Css NA 0.03436 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047825 Css NA 0.00587 mg/L PBTK NA 50% Rat Human +DTXSID5047825 Css NA 0.02123 mg/L PBTK NA 95% Rat Human +DTXSID5047879 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047879 Fup 0.0246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047879 Vd NA 1.673 L/kg 1compartment NA NA Human Human +DTXSID5047879 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5047879 TK.Half.Life NA 13.68 hours 1compartment NA NA Human Human +DTXSID5047879 Css NA 1.227 mg/L 3compartmentss NA 50% Human Human +DTXSID5047879 Css NA 10.68 mg/L 3compartmentss NA 95% Human Human +DTXSID5047879 Css NA 0.7807 mg/L PBTK NA 50% Human Human +DTXSID5047879 Css NA 6.575 mg/L PBTK NA 95% Human Human +DTXSID5047879 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047879 Fup 0.0246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047879 Vd NA 1.243 L/kg 1compartment NA NA Rat Human DTXSID5047879 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047879 TK.Half.Life NA 3.44 hours 1compartment NA NA Rat Human -DTXSID5047879 Css NA 0.3678 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047879 Css NA 1.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047879 Css NA 0.2327 mg/L PBTK NA 50% Rat Human -DTXSID5047879 Css NA 1.192 mg/L PBTK NA 95% Rat Human -DTXSID5047900 Clint NA 885.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047900 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047900 Vd NA 468.8 L/kg 1compartment NA NA Human Human -DTXSID5047900 Days.Css NA 70 Days PBTK NA NA Human Human -DTXSID5047900 TK.Half.Life NA 349.4 hours 1compartment NA NA Human Human -DTXSID5047900 Css NA 0.0008912 mg/L 3compartmentss NA 50% Human Human -DTXSID5047900 Css NA 0.00525 mg/L 3compartmentss NA 95% Human Human -DTXSID5047900 Css NA 0.06186 mg/L PBTK NA 50% Human Human -DTXSID5047900 Css NA 0.3418 mg/L PBTK NA 95% Human Human -DTXSID5047900 Clint NA 885.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047900 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047900 Vd NA 423 L/kg 1compartment NA NA Rat Human -DTXSID5047900 Days.Css NA 52 Days PBTK NA NA Rat Human -DTXSID5047900 TK.Half.Life NA 58.74 hours 1compartment NA NA Rat Human -DTXSID5047900 Css NA 0.0004522 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047900 Css NA 0.001926 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047900 Css NA 0.03323 mg/L PBTK NA 50% Rat Human -DTXSID5047900 Css NA 0.1442 mg/L PBTK NA 95% Rat Human +DTXSID5047879 TK.Half.Life NA 4.987 hours 1compartment NA NA Rat Human +DTXSID5047879 Css NA 0.1577 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047879 Css NA 1.075 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047879 Css NA 0.09708 mg/L PBTK NA 50% Rat Human +DTXSID5047879 Css NA 0.6321 mg/L PBTK NA 95% Rat Human DTXSID5047902 Clint NA 0.09277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5047902 Fup NA 0.723 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047902 Vd NA 1.369 L/kg 1compartment NA NA Human Human -DTXSID5047902 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5047902 TK.Half.Life NA 10.63 hours 1compartment NA NA Human Human -DTXSID5047902 Css NA 0.7904 mg/L 3compartmentss NA 50% Human Human -DTXSID5047902 Css NA 5.288 mg/L 3compartmentss NA 95% Human Human -DTXSID5047902 Css NA 0.7338 mg/L PBTK NA 50% Human Human -DTXSID5047902 Css NA 3.55 mg/L PBTK NA 95% Human Human +DTXSID5047902 Vd NA 1.293 L/kg 1compartment NA NA Human Human +DTXSID5047902 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047902 TK.Half.Life NA 10.03 hours 1compartment NA NA Human Human +DTXSID5047902 Css NA 0.6832 mg/L 3compartmentss NA 50% Human Human +DTXSID5047902 Css NA 4.689 mg/L 3compartmentss NA 95% Human Human +DTXSID5047902 Css NA 0.6285 mg/L PBTK NA 50% Human Human +DTXSID5047902 Css NA 3.109 mg/L PBTK NA 95% Human Human DTXSID5047902 Clint NA 0.09277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5047902 Fup NA 0.723 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047902 Vd NA 1.395 L/kg 1compartment NA NA Rat Human +DTXSID5047902 Vd NA 1.323 L/kg 1compartment NA NA Rat Human DTXSID5047902 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047902 TK.Half.Life NA 3.959 hours 1compartment NA NA Rat Human -DTXSID5047902 Css NA 0.22 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047902 Css NA 1.588 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047902 Css NA 0.1996 mg/L PBTK NA 50% Rat Human -DTXSID5047902 Css NA 0.9749 mg/L PBTK NA 95% Rat Human -DTXSID5047904 Clint NA 356.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047904 Fup NA 0.1157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047904 Vd NA 4.633 L/kg 1compartment NA NA Human Human -DTXSID5047904 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5047904 TK.Half.Life NA 2.134 hours 1compartment NA NA Human Human -DTXSID5047904 Css NA 0.001126 mg/L 3compartmentss NA 50% Human Human -DTXSID5047904 Css NA 0.01001 mg/L 3compartmentss NA 95% Human Human -DTXSID5047904 Css NA 0.00129 mg/L PBTK NA 50% Human Human -DTXSID5047904 Css NA 0.00938 mg/L PBTK NA 95% Human Human -DTXSID5047904 Clint NA 356.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047904 Fup NA 0.1157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047904 Vd NA 4.291 L/kg 1compartment NA NA Rat Human -DTXSID5047904 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047904 TK.Half.Life NA 0.8621 hours 1compartment NA NA Rat Human -DTXSID5047904 Css NA 0.0006076 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047904 Css NA 0.00417 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047904 Css NA 0.0006991 mg/L PBTK NA 50% Rat Human -DTXSID5047904 Css NA 0.003928 mg/L PBTK NA 95% Rat Human -DTXSID5047950 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047950 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047950 Vd NA 478.8 L/kg 1compartment NA NA Human Human -DTXSID5047950 Days.Css NA 96 Days PBTK NA NA Human Human -DTXSID5047950 TK.Half.Life NA 455.4 hours 1compartment NA NA Human Human -DTXSID5047950 Css NA 0.001119 mg/L 3compartmentss NA 50% Human Human -DTXSID5047950 Css NA 0.00673 mg/L 3compartmentss NA 95% Human Human -DTXSID5047950 Css NA 0.07869 mg/L PBTK NA 50% Human Human -DTXSID5047950 Css NA 0.4336 mg/L PBTK NA 95% Human Human -DTXSID5047950 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047950 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047950 Vd NA 432.2 L/kg 1compartment NA NA Rat Human -DTXSID5047950 Days.Css NA 70 Days PBTK NA NA Rat Human -DTXSID5047950 TK.Half.Life NA 76.25 hours 1compartment NA NA Rat Human -DTXSID5047950 Css NA 0.0005635 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047950 Css NA 0.002513 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047950 Css NA 0.04275 mg/L PBTK NA 50% Rat Human -DTXSID5047950 Css NA 0.1912 mg/L PBTK NA 95% Rat Human -DTXSID5047954 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047954 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047954 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID5047954 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5047954 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID5047954 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID5047954 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5047954 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID5047954 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID5047954 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047954 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047954 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID5047954 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5047954 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID5047954 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047954 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047954 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID5047954 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID5047956 Clint NA 0.5269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047956 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5047956 Vd NA 0.4308 L/kg 1compartment NA NA Human Human -DTXSID5047956 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID5047956 TK.Half.Life NA 59.65 hours 1compartment NA NA Human Human -DTXSID5047956 Css NA 23.44 mg/L 3compartmentss NA 50% Human Human -DTXSID5047956 Css NA 147.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5047956 Css NA 13.95 mg/L PBTK NA 50% Human Human -DTXSID5047956 Css NA 86.01 mg/L PBTK NA 95% Human Human -DTXSID5047956 Clint NA 0.5269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047956 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5047956 Vd NA 0.3453 L/kg 1compartment NA NA Rat Human -DTXSID5047956 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5047956 TK.Half.Life NA 21.31 hours 1compartment NA NA Rat Human -DTXSID5047956 Css NA 9.072 mg/L 3compartmentss NA 50% Rat Human -DTXSID5047956 Css NA 49.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID5047956 Css NA 5.039 mg/L PBTK NA 50% Rat Human -DTXSID5047956 Css NA 26.88 mg/L PBTK NA 95% Rat Human +DTXSID5047902 TK.Half.Life NA 3.753 hours 1compartment NA NA Rat Human +DTXSID5047902 Css NA 0.01409 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047902 Css NA 0.124 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047902 Css NA 0.01259 mg/L PBTK NA 50% Rat Human +DTXSID5047902 Css NA 0.08378 mg/L PBTK NA 95% Rat Human +DTXSID5047956 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047956 Fup 0.0403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5047956 Vd NA 0.5796 L/kg 1compartment NA NA Human Human +DTXSID5047956 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5047956 TK.Half.Life NA 2.928 hours 1compartment NA NA Human Human +DTXSID5047956 Css NA 0.753 mg/L 3compartmentss NA 50% Human Human +DTXSID5047956 Css NA 7.224 mg/L 3compartmentss NA 95% Human Human +DTXSID5047956 Css NA 0.4548 mg/L PBTK NA 50% Human Human +DTXSID5047956 Css NA 4.275 mg/L PBTK NA 95% Human Human +DTXSID5047956 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047956 Fup 0.0403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5047956 Vd NA 0.4565 L/kg 1compartment NA NA Rat Human +DTXSID5047956 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5047956 TK.Half.Life NA 1.422 hours 1compartment NA NA Rat Human +DTXSID5047956 Css NA 0.1008 mg/L 3compartmentss NA 50% Rat Human +DTXSID5047956 Css NA 0.7421 mg/L 3compartmentss NA 95% Rat Human +DTXSID5047956 Css NA 0.05903 mg/L PBTK NA 50% Rat Human +DTXSID5047956 Css NA 0.4228 mg/L PBTK NA 95% Rat Human DTXSID5048180 Clint 17.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5048180 Fup 0.136 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5048180 Vd NA 1.306 L/kg 1compartment NA NA Human Human DTXSID5048180 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID5048180 TK.Half.Life NA 3.339 hours 1compartment NA NA Human Human -DTXSID5048180 Css NA 0.2192 mg/L 3compartmentss NA 50% Human Human -DTXSID5048180 Css NA 1.379 mg/L 3compartmentss NA 95% Human Human -DTXSID5048180 Css NA 0.1513 mg/L PBTK NA 50% Human Human -DTXSID5048180 Css NA 0.9076 mg/L PBTK NA 95% Human Human +DTXSID5048180 Css NA 0.2104 mg/L 3compartmentss NA 50% Human Human +DTXSID5048180 Css NA 1.385 mg/L 3compartmentss NA 95% Human Human +DTXSID5048180 Css NA 0.1461 mg/L PBTK NA 50% Human Human +DTXSID5048180 Css NA 0.9095 mg/L PBTK NA 95% Human Human DTXSID5048180 Clint 17.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5048180 Fup 0.136 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5048180 Vd NA 1.027 L/kg 1compartment NA NA Rat Human DTXSID5048180 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID5048180 TK.Half.Life NA 1.384 hours 1compartment NA NA Rat Human -DTXSID5048180 Css NA 0.119 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048180 Css NA 0.5656 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048180 Css NA 0.07789 mg/L PBTK NA 50% Rat Human -DTXSID5048180 Css NA 0.3534 mg/L PBTK NA 95% Rat Human +DTXSID5048180 Css NA 0.02679 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048180 Css NA 0.1328 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048180 Css NA 0.0182 mg/L PBTK NA 50% Rat Human +DTXSID5048180 Css NA 0.08605 mg/L PBTK NA 95% Rat Human +DTXSID5048182 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048182 Fup 0.0227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048182 Vd NA 1.91 L/kg 1compartment NA NA Human Human +DTXSID5048182 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5048182 TK.Half.Life NA 17.47 hours 1compartment NA NA Human Human +DTXSID5048182 Css NA 1.336 mg/L 3compartmentss NA 50% Human Human +DTXSID5048182 Css NA 11.35 mg/L 3compartmentss NA 95% Human Human +DTXSID5048182 Css NA 0.858 mg/L PBTK NA 50% Human Human +DTXSID5048182 Css NA 6.973 mg/L PBTK NA 95% Human Human +DTXSID5048182 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048182 Fup 0.0227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048182 Vd NA 1.421 L/kg 1compartment NA NA Rat Human +DTXSID5048182 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048182 TK.Half.Life NA 5.839 hours 1compartment NA NA Rat Human +DTXSID5048182 Css NA 0.1736 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048182 Css NA 1.218 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048182 Css NA 0.1088 mg/L PBTK NA 50% Rat Human +DTXSID5048182 Css NA 0.7264 mg/L PBTK NA 95% Rat Human DTXSID5048184 Clint 41.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5048184 Fup 0.0232 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5048184 Vd NA 1.388 L/kg 1compartment NA NA Human Human +DTXSID5048184 Vd NA 1.615 L/kg 1compartment NA NA Human Human DTXSID5048184 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048184 TK.Half.Life NA 6.576 hours 1compartment NA NA Human Human -DTXSID5048184 Css NA 0.5316 mg/L 3compartmentss NA 50% Human Human -DTXSID5048184 Css NA 3.861 mg/L 3compartmentss NA 95% Human Human -DTXSID5048184 Css NA 0.3344 mg/L PBTK NA 50% Human Human -DTXSID5048184 Css NA 2.359 mg/L PBTK NA 95% Human Human +DTXSID5048184 TK.Half.Life NA 7.883 hours 1compartment NA NA Human Human +DTXSID5048184 Css NA 0.5296 mg/L 3compartmentss NA 50% Human Human +DTXSID5048184 Css NA 3.949 mg/L 3compartmentss NA 95% Human Human +DTXSID5048184 Css NA 0.3384 mg/L PBTK NA 50% Human Human +DTXSID5048184 Css NA 2.438 mg/L PBTK NA 95% Human Human DTXSID5048184 Clint 41.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5048184 Fup 0.0232 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5048184 Vd NA 1.032 L/kg 1compartment NA NA Rat Human +DTXSID5048184 Vd NA 1.2 L/kg 1compartment NA NA Rat Human DTXSID5048184 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048184 TK.Half.Life NA 2.593 hours 1compartment NA NA Rat Human -DTXSID5048184 Css NA 0.2961 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048184 Css NA 1.756 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048184 Css NA 0.1764 mg/L PBTK NA 50% Rat Human -DTXSID5048184 Css NA 1.012 mg/L PBTK NA 95% Rat Human +DTXSID5048184 TK.Half.Life NA 2.917 hours 1compartment NA NA Rat Human +DTXSID5048184 Css NA 0.06831 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048184 Css NA 0.4069 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048184 Css NA 0.04253 mg/L PBTK NA 50% Rat Human +DTXSID5048184 Css NA 0.2465 mg/L PBTK NA 95% Rat Human DTXSID5048186 Clint NA 23.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5048186 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048186 Vd NA 5.901 L/kg 1compartment NA NA Human Human -DTXSID5048186 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID5048186 TK.Half.Life NA 128.6 hours 1compartment NA NA Human Human -DTXSID5048186 Css NA 2.524 mg/L 3compartmentss NA 50% Human Human -DTXSID5048186 Css NA 21 mg/L 3compartmentss NA 95% Human Human -DTXSID5048186 Css NA 2.141 mg/L PBTK NA 50% Human Human -DTXSID5048186 Css NA 15.73 mg/L PBTK NA 95% Human Human +DTXSID5048186 Vd NA 0.9676 L/kg 1compartment NA NA Human Human +DTXSID5048186 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5048186 TK.Half.Life NA 23.87 hours 1compartment NA NA Human Human +DTXSID5048186 Css NA 3.742 mg/L 3compartmentss NA 50% Human Human +DTXSID5048186 Css NA 35.39 mg/L 3compartmentss NA 95% Human Human +DTXSID5048186 Css NA 2.238 mg/L PBTK NA 50% Human Human +DTXSID5048186 Css NA 20.61 mg/L PBTK NA 95% Human Human DTXSID5048186 Clint NA 23.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5048186 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048186 Vd NA 4.541 L/kg 1compartment NA NA Rat Human -DTXSID5048186 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID5048186 TK.Half.Life NA 33.68 hours 1compartment NA NA Rat Human -DTXSID5048186 Css NA 1.393 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048186 Css NA 9.462 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048186 Css NA 1.144 mg/L PBTK NA 50% Rat Human -DTXSID5048186 Css NA 6.966 mg/L PBTK NA 95% Rat Human -DTXSID5048421 Clint NA 5.569 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048421 Fup NA 0.19 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048421 Vd NA 1.7 L/kg 1compartment NA NA Human Human -DTXSID5048421 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048421 TK.Half.Life NA 8.223 hours 1compartment NA NA Human Human -DTXSID5048421 Css NA 0.5069 mg/L 3compartmentss NA 50% Human Human -DTXSID5048421 Css NA 2.74 mg/L 3compartmentss NA 95% Human Human -DTXSID5048421 Css NA 0.3684 mg/L PBTK NA 50% Human Human -DTXSID5048421 Css NA 1.83 mg/L PBTK NA 95% Human Human -DTXSID5048421 Clint NA 5.569 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048421 Fup NA 0.19 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048421 Vd NA 1.348 L/kg 1compartment NA NA Rat Human -DTXSID5048421 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048421 TK.Half.Life NA 3.139 hours 1compartment NA NA Rat Human -DTXSID5048421 Css NA 0.2586 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048421 Css NA 1.012 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048421 Css NA 0.1796 mg/L PBTK NA 50% Rat Human -DTXSID5048421 Css NA 0.6439 mg/L PBTK NA 95% Rat Human -DTXSID5048506 Clint NA 16.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048506 Fup NA 0.043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048506 Vd NA 2.597 L/kg 1compartment NA NA Human Human -DTXSID5048506 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5048506 TK.Half.Life NA 28.82 hours 1compartment NA NA Human Human -DTXSID5048506 Css NA 1.472 mg/L 3compartmentss NA 50% Human Human -DTXSID5048506 Css NA 9.559 mg/L 3compartmentss NA 95% Human Human -DTXSID5048506 Css NA 0.995 mg/L PBTK NA 50% Human Human -DTXSID5048506 Css NA 6.259 mg/L PBTK NA 95% Human Human -DTXSID5048506 Clint NA 16.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048506 Fup NA 0.043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048506 Vd NA 1.945 L/kg 1compartment NA NA Rat Human -DTXSID5048506 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5048506 TK.Half.Life NA 6.717 hours 1compartment NA NA Rat Human -DTXSID5048506 Css NA 0.8182 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048506 Css NA 4.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048506 Css NA 0.5258 mg/L PBTK NA 50% Rat Human -DTXSID5048506 Css NA 2.55 mg/L PBTK NA 95% Rat Human -DTXSID5048631 Clint NA 3426 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048631 Fup NA 0.0893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048631 Vd NA 1.056 L/kg 1compartment NA NA Human Human -DTXSID5048631 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048631 TK.Half.Life NA 0.8975 hours 1compartment NA NA Human Human -DTXSID5048631 Css NA 0.00206 mg/L 3compartmentss NA 50% Human Human -DTXSID5048631 Css NA 0.01822 mg/L 3compartmentss NA 95% Human Human -DTXSID5048631 Css NA 0.001359 mg/L PBTK NA 50% Human Human -DTXSID5048631 Css NA 0.01149 mg/L PBTK NA 95% Human Human -DTXSID5048631 Clint NA 3426 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048631 Fup NA 0.0893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048631 Vd NA 0.9298 L/kg 1compartment NA NA Rat Human -DTXSID5048631 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048631 TK.Half.Life NA 0.348 hours 1compartment NA NA Rat Human -DTXSID5048631 Css NA 0.001176 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048631 Css NA 0.008834 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048631 Css NA 0.0007315 mg/L PBTK NA 50% Rat Human -DTXSID5048631 Css NA 0.005198 mg/L PBTK NA 95% Rat Human -DTXSID5048633 Clint NA 962.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048633 Fup NA 0.1543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048633 Vd NA 2.6 L/kg 1compartment NA NA Human Human +DTXSID5048186 Vd NA 0.7102 L/kg 1compartment NA NA Rat Human +DTXSID5048186 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5048186 TK.Half.Life NA 10.61 hours 1compartment NA NA Rat Human +DTXSID5048186 Css NA 0.1446 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048186 Css NA 1.538 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048186 Css NA 0.08241 mg/L PBTK NA 50% Rat Human +DTXSID5048186 Css NA 0.8593 mg/L PBTK NA 95% Rat Human +DTXSID5048211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048211 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048211 Vd NA 1.53 L/kg 1compartment NA NA Human Human +DTXSID5048211 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048211 TK.Half.Life NA 3.44 hours 1compartment NA NA Human Human +DTXSID5048211 Css NA 0.2076 mg/L 3compartmentss NA 50% Human Human +DTXSID5048211 Css NA 1.598 mg/L 3compartmentss NA 95% Human Human +DTXSID5048211 Css NA 0.1422 mg/L PBTK NA 50% Human Human +DTXSID5048211 Css NA 1.037 mg/L PBTK NA 95% Human Human +DTXSID5048211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048211 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048211 Vd NA 1.185 L/kg 1compartment NA NA Rat Human +DTXSID5048211 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048211 TK.Half.Life NA 1.329 hours 1compartment NA NA Rat Human +DTXSID5048211 Css NA 0.02654 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048211 Css NA 0.1597 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048211 Css NA 0.01782 mg/L PBTK NA 50% Rat Human +DTXSID5048211 Css NA 0.1015 mg/L PBTK NA 95% Rat Human +DTXSID5048265 Clint 28 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID5048265 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5048265 Vd NA 2.648 L/kg 1compartment NA NA Human Human +DTXSID5048265 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048265 TK.Half.Life NA 4.146 hours 1compartment NA NA Human Human +DTXSID5048265 Css NA 0.1137 mg/L 3compartmentss NA 50% Human Human +DTXSID5048265 Css NA 1.083 mg/L 3compartmentss NA 95% Human Human +DTXSID5048265 Css NA 0.09779 mg/L PBTK NA 50% Human Human +DTXSID5048265 Css NA 0.7886 mg/L PBTK NA 95% Human Human +DTXSID5048265 Clint 28 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID5048265 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5048265 Vd NA 2.554 L/kg 1compartment NA NA Rat Human +DTXSID5048265 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048265 TK.Half.Life NA 2.2 hours 1compartment NA NA Rat Human +DTXSID5048265 Css NA 0.01455 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048265 Css NA 0.1154 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048265 Css NA 0.01248 mg/L PBTK NA 50% Rat Human +DTXSID5048265 Css NA 0.08253 mg/L PBTK NA 95% Rat Human +DTXSID5048340 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048340 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID5048340 Vd NA 0.2775 L/kg 1compartment NA NA Human Human +DTXSID5048340 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5048340 TK.Half.Life NA 11.97 hours 1compartment NA NA Human Human +DTXSID5048340 Css NA 5.318 mg/L 3compartmentss NA 50% Human Human +DTXSID5048340 Css NA 23.8 mg/L 3compartmentss NA 95% Human Human +DTXSID5048340 Css NA 3.316 mg/L PBTK NA 50% Human Human +DTXSID5048340 Css NA 13.97 mg/L PBTK NA 95% Human Human +DTXSID5048340 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048340 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID5048340 Vd NA 0.289 L/kg 1compartment NA NA Rat Human +DTXSID5048340 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048340 TK.Half.Life NA 4.247 hours 1compartment NA NA Rat Human +DTXSID5048340 Css NA 0.09857 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048340 Css NA 0.6335 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048340 Css NA 0.05868 mg/L PBTK NA 50% Rat Human +DTXSID5048340 Css NA 0.3631 mg/L PBTK NA 95% Rat Human +DTXSID5048342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048342 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048342 Vd NA 2.837 L/kg 1compartment NA NA Human Human +DTXSID5048342 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048342 TK.Half.Life NA 6.723 hours 1compartment NA NA Human Human +DTXSID5048342 Css NA 0.1833 mg/L 3compartmentss NA 50% Human Human +DTXSID5048342 Css NA 1.168 mg/L 3compartmentss NA 95% Human Human +DTXSID5048342 Css NA 0.141 mg/L PBTK NA 50% Human Human +DTXSID5048342 Css NA 0.8451 mg/L PBTK NA 95% Human Human +DTXSID5048342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048342 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048342 Vd NA 2.228 L/kg 1compartment NA NA Rat Human +DTXSID5048342 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048342 TK.Half.Life NA 1.806 hours 1compartment NA NA Rat Human +DTXSID5048342 Css NA 0.02319 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048342 Css NA 0.1162 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048342 Css NA 0.01787 mg/L PBTK NA 50% Rat Human +DTXSID5048342 Css NA 0.08449 mg/L PBTK NA 95% Rat Human +DTXSID5048390 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048390 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048390 Vd NA 0.5964 L/kg 1compartment NA NA Human Human +DTXSID5048390 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5048390 TK.Half.Life NA 26.29 hours 1compartment NA NA Human Human +DTXSID5048390 Css NA 7.613 mg/L 3compartmentss NA 50% Human Human +DTXSID5048390 Css NA 68.17 mg/L 3compartmentss NA 95% Human Human +DTXSID5048390 Css NA 4.74 mg/L PBTK NA 50% Human Human +DTXSID5048390 Css NA 40.01 mg/L PBTK NA 95% Human Human +DTXSID5048390 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048390 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048390 Vd NA 0.4916 L/kg 1compartment NA NA Rat Human +DTXSID5048390 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5048390 TK.Half.Life NA 13.54 hours 1compartment NA NA Rat Human +DTXSID5048390 Css NA 0.9296 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048390 Css NA 6.607 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048390 Css NA 0.5609 mg/L PBTK NA 50% Rat Human +DTXSID5048390 Css NA 3.791 mg/L PBTK NA 95% Rat Human +DTXSID5048421 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048421 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048421 Vd NA 2.991 L/kg 1compartment NA NA Human Human +DTXSID5048421 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5048421 TK.Half.Life NA 28.06 hours 1compartment NA NA Human Human +DTXSID5048421 Css NA 0.9992 mg/L 3compartmentss NA 50% Human Human +DTXSID5048421 Css NA 5.411 mg/L 3compartmentss NA 95% Human Human +DTXSID5048421 Css NA 0.7372 mg/L PBTK NA 50% Human Human +DTXSID5048421 Css NA 3.835 mg/L PBTK NA 95% Human Human +DTXSID5048421 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048421 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048421 Vd NA 2.271 L/kg 1compartment NA NA Rat Human +DTXSID5048421 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5048421 TK.Half.Life NA 4.81 hours 1compartment NA NA Rat Human +DTXSID5048421 Css NA 0.1206 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048421 Css NA 0.456 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048421 Css NA 0.08856 mg/L PBTK NA 50% Rat Human +DTXSID5048421 Css NA 0.3244 mg/L PBTK NA 95% Rat Human +DTXSID5048506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048506 Fup 0.0216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048506 Vd NA 2.834 L/kg 1compartment NA NA Human Human +DTXSID5048506 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID5048506 TK.Half.Life NA 43.9 hours 1compartment NA NA Human Human +DTXSID5048506 Css NA 2.006 mg/L 3compartmentss NA 50% Human Human +DTXSID5048506 Css NA 13.91 mg/L 3compartmentss NA 95% Human Human +DTXSID5048506 Css NA 1.353 mg/L PBTK NA 50% Human Human +DTXSID5048506 Css NA 9.068 mg/L PBTK NA 95% Human Human +DTXSID5048506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048506 Fup 0.0216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048506 Vd NA 2.119 L/kg 1compartment NA NA Rat Human +DTXSID5048506 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5048506 TK.Half.Life NA 8.359 hours 1compartment NA NA Rat Human +DTXSID5048506 Css NA 0.258 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048506 Css NA 1.529 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048506 Css NA 0.1723 mg/L PBTK NA 50% Rat Human +DTXSID5048506 Css NA 1.006 mg/L PBTK NA 95% Rat Human +DTXSID5048550 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048550 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048550 Vd NA 2.158 L/kg 1compartment NA NA Human Human +DTXSID5048550 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048550 TK.Half.Life NA 4.972 hours 1compartment NA NA Human Human +DTXSID5048550 Css NA 0.1487 mg/L 3compartmentss NA 50% Human Human +DTXSID5048550 Css NA 1.014 mg/L 3compartmentss NA 95% Human Human +DTXSID5048550 Css NA 0.1304 mg/L PBTK NA 50% Human Human +DTXSID5048550 Css NA 0.7607 mg/L PBTK NA 95% Human Human +DTXSID5048550 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048550 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048550 Vd NA 1.936 L/kg 1compartment NA NA Rat Human +DTXSID5048550 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048550 TK.Half.Life NA 2.243 hours 1compartment NA NA Rat Human +DTXSID5048550 Css NA 0.006598 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048550 Css NA 0.04849 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048550 Css NA 0.005884 mg/L PBTK NA 50% Rat Human +DTXSID5048550 Css NA 0.03658 mg/L PBTK NA 95% Rat Human +DTXSID5048633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048633 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048633 Vd NA 2.335 L/kg 1compartment NA NA Human Human DTXSID5048633 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048633 TK.Half.Life NA 1.56 hours 1compartment NA NA Human Human -DTXSID5048633 Css NA 0.002354 mg/L 3compartmentss NA 50% Human Human -DTXSID5048633 Css NA 0.02244 mg/L 3compartmentss NA 95% Human Human -DTXSID5048633 Css NA 0.002163 mg/L PBTK NA 50% Human Human -DTXSID5048633 Css NA 0.01691 mg/L PBTK NA 95% Human Human -DTXSID5048633 Clint NA 962.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048633 Fup NA 0.1543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048633 Vd NA 2.589 L/kg 1compartment NA NA Rat Human +DTXSID5048633 TK.Half.Life NA 6.472 hours 1compartment NA NA Human Human +DTXSID5048633 Css NA 0.2506 mg/L 3compartmentss NA 50% Human Human +DTXSID5048633 Css NA 1.62 mg/L 3compartmentss NA 95% Human Human +DTXSID5048633 Css NA 0.1776 mg/L PBTK NA 50% Human Human +DTXSID5048633 Css NA 1.108 mg/L PBTK NA 95% Human Human +DTXSID5048633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048633 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048633 Vd NA 1.777 L/kg 1compartment NA NA Rat Human DTXSID5048633 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048633 TK.Half.Life NA 0.6918 hours 1compartment NA NA Rat Human -DTXSID5048633 Css NA 0.001315 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048633 Css NA 0.01053 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048633 Css NA 0.00117 mg/L PBTK NA 50% Rat Human -DTXSID5048633 Css NA 0.007511 mg/L PBTK NA 95% Rat Human -DTXSID5048635 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048635 Fup NA 0.1738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048635 Vd NA 2.867 L/kg 1compartment NA NA Human Human -DTXSID5048635 Days.Css NA 167 Days PBTK NA NA Human Human -DTXSID5048635 TK.Half.Life NA 681.6 hours 1compartment NA NA Human Human -DTXSID5048635 Css NA 26.7 mg/L 3compartmentss NA 50% Human Human -DTXSID5048635 Css NA 76.01 mg/L 3compartmentss NA 95% Human Human -DTXSID5048635 Css NA 19.11 mg/L PBTK NA 50% Human Human -DTXSID5048635 Css NA 50.57 mg/L PBTK NA 95% Human Human -DTXSID5048635 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048635 Fup NA 0.1738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048635 Vd NA 2.164 L/kg 1compartment NA NA Rat Human -DTXSID5048635 Days.Css NA 41 Days PBTK NA NA Rat Human -DTXSID5048635 TK.Half.Life NA 62.67 hours 1compartment NA NA Rat Human -DTXSID5048635 Css NA 7.212 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048635 Css NA 16.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048635 Css NA 4.944 mg/L PBTK NA 50% Rat Human -DTXSID5048635 Css NA 10.04 mg/L PBTK NA 95% Rat Human -DTXSID5048637 Clint NA 11.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048637 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048637 Vd NA 2.618 L/kg 1compartment NA NA Human Human -DTXSID5048637 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5048637 TK.Half.Life NA 31.99 hours 1compartment NA NA Human Human -DTXSID5048637 Css NA 1.598 mg/L 3compartmentss NA 50% Human Human -DTXSID5048637 Css NA 10.14 mg/L 3compartmentss NA 95% Human Human -DTXSID5048637 Css NA 1.088 mg/L PBTK NA 50% Human Human -DTXSID5048637 Css NA 6.636 mg/L PBTK NA 95% Human Human -DTXSID5048637 Clint NA 11.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048637 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048637 Vd NA 1.971 L/kg 1compartment NA NA Rat Human -DTXSID5048637 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5048637 TK.Half.Life NA 7.425 hours 1compartment NA NA Rat Human -DTXSID5048637 Css NA 0.8838 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048637 Css NA 4.147 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048637 Css NA 0.5736 mg/L PBTK NA 50% Rat Human -DTXSID5048637 Css NA 2.586 mg/L PBTK NA 95% Rat Human -DTXSID5048639 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048639 Fup NA 0.0656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048639 Vd NA 0.5482 L/kg 1compartment NA NA Human Human -DTXSID5048639 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID5048639 TK.Half.Life NA 54.32 hours 1compartment NA NA Human Human -DTXSID5048639 Css NA 13.78 mg/L 3compartmentss NA 50% Human Human -DTXSID5048639 Css NA 60.06 mg/L 3compartmentss NA 95% Human Human -DTXSID5048639 Css NA 9.284 mg/L PBTK NA 50% Human Human -DTXSID5048639 Css NA 36.12 mg/L PBTK NA 95% Human Human -DTXSID5048639 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048639 Fup NA 0.0656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048639 Vd NA 0.5299 L/kg 1compartment NA NA Rat Human -DTXSID5048639 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5048639 TK.Half.Life NA 17.83 hours 1compartment NA NA Rat Human -DTXSID5048639 Css NA 3.872 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048639 Css NA 13.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048639 Css NA 2.459 mg/L PBTK NA 50% Rat Human -DTXSID5048639 Css NA 7.797 mg/L PBTK NA 95% Rat Human -DTXSID5048681 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048681 Fup NA 0.9469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048681 Vd NA 1.341 L/kg 1compartment NA NA Human Human -DTXSID5048681 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048681 TK.Half.Life NA 9.825 hours 1compartment NA NA Human Human -DTXSID5048681 Css NA 0.829 mg/L 3compartmentss NA 50% Human Human -DTXSID5048681 Css NA 4.759 mg/L 3compartmentss NA 95% Human Human -DTXSID5048681 Css NA 0.7654 mg/L PBTK NA 50% Human Human -DTXSID5048681 Css NA 3.244 mg/L PBTK NA 95% Human Human -DTXSID5048681 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048681 Fup NA 0.9469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048681 Vd NA 1.253 L/kg 1compartment NA NA Rat Human +DTXSID5048633 TK.Half.Life NA 1.915 hours 1compartment NA NA Rat Human +DTXSID5048633 Css NA 0.03226 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048633 Css NA 0.1663 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048633 Css NA 0.02269 mg/L PBTK NA 50% Rat Human +DTXSID5048633 Css NA 0.1131 mg/L PBTK NA 95% Rat Human +DTXSID5048635 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048635 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048635 Vd NA 0.4503 L/kg 1compartment NA NA Human Human +DTXSID5048635 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048635 TK.Half.Life NA 2.37 hours 1compartment NA NA Human Human +DTXSID5048635 Css NA 0.5798 mg/L 3compartmentss NA 50% Human Human +DTXSID5048635 Css NA 4.516 mg/L 3compartmentss NA 95% Human Human +DTXSID5048635 Css NA 0.3896 mg/L PBTK NA 50% Human Human +DTXSID5048635 Css NA 2.791 mg/L PBTK NA 95% Human Human +DTXSID5048635 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048635 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048635 Vd NA 0.4283 L/kg 1compartment NA NA Rat Human +DTXSID5048635 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048635 TK.Half.Life NA 1.362 hours 1compartment NA NA Rat Human +DTXSID5048635 Css NA 0.02677 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048635 Css NA 0.2145 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048635 Css NA 0.01745 mg/L PBTK NA 50% Rat Human +DTXSID5048635 Css NA 0.1289 mg/L PBTK NA 95% Rat Human +DTXSID5048637 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048637 Fup 0.181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048637 Vd NA 0.3359 L/kg 1compartment NA NA Human Human +DTXSID5048637 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048637 TK.Half.Life NA 0.6001 hours 1compartment NA NA Human Human +DTXSID5048637 Css NA 0.126 mg/L 3compartmentss NA 50% Human Human +DTXSID5048637 Css NA 0.8913 mg/L 3compartmentss NA 95% Human Human +DTXSID5048637 Css NA 0.081 mg/L PBTK NA 50% Human Human +DTXSID5048637 Css NA 0.5535 mg/L PBTK NA 95% Human Human +DTXSID5048637 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048637 Fup 0.181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048637 Vd NA 0.3461 L/kg 1compartment NA NA Rat Human +DTXSID5048637 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048637 TK.Half.Life NA 0.345 hours 1compartment NA NA Rat Human +DTXSID5048637 Css NA 0.01597 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048637 Css NA 0.08487 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048637 Css NA 0.01001 mg/L PBTK NA 50% Rat Human +DTXSID5048637 Css NA 0.05121 mg/L PBTK NA 95% Rat Human +DTXSID5048639 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048639 Fup 0.0384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048639 Vd NA 0.4696 L/kg 1compartment NA NA Human Human +DTXSID5048639 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID5048639 TK.Half.Life NA 79.56 hours 1compartment NA NA Human Human +DTXSID5048639 Css NA 23.53 mg/L 3compartmentss NA 50% Human Human +DTXSID5048639 Css NA 144.1 mg/L 3compartmentss NA 95% Human Human +DTXSID5048639 Css NA 15.12 mg/L PBTK NA 50% Human Human +DTXSID5048639 Css NA 84.52 mg/L PBTK NA 95% Human Human +DTXSID5048639 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048639 Fup 0.0384 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048639 Vd NA 0.4452 L/kg 1compartment NA NA Rat Human +DTXSID5048639 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID5048639 TK.Half.Life NA 25.59 hours 1compartment NA NA Rat Human +DTXSID5048639 Css NA 0.5628 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048639 Css NA 4.56 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048639 Css NA 0.3526 mg/L PBTK NA 50% Rat Human +DTXSID5048639 Css NA 2.63 mg/L PBTK NA 95% Rat Human +DTXSID5048681 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048681 Fup 0.693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048681 Vd NA 1.619 L/kg 1compartment NA NA Human Human +DTXSID5048681 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5048681 TK.Half.Life NA 18.45 hours 1compartment NA NA Human Human +DTXSID5048681 Css NA 1.091 mg/L 3compartmentss NA 50% Human Human +DTXSID5048681 Css NA 7.265 mg/L 3compartmentss NA 95% Human Human +DTXSID5048681 Css NA 0.9842 mg/L PBTK NA 50% Human Human +DTXSID5048681 Css NA 4.825 mg/L PBTK NA 95% Human Human +DTXSID5048681 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048681 Fup 0.693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048681 Vd NA 1.398 L/kg 1compartment NA NA Rat Human DTXSID5048681 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048681 TK.Half.Life NA 2.967 hours 1compartment NA NA Rat Human -DTXSID5048681 Css NA 0.2096 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048681 Css NA 1.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048681 Css NA 0.1906 mg/L PBTK NA 50% Rat Human -DTXSID5048681 Css NA 0.7481 mg/L PBTK NA 95% Rat Human -DTXSID5048683 Clint NA 1668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048683 Fup NA 0.037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048683 Vd NA 3.078 L/kg 1compartment NA NA Human Human -DTXSID5048683 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048683 TK.Half.Life NA 3.324 hours 1compartment NA NA Human Human -DTXSID5048683 Css NA 0.0331 mg/L 3compartmentss NA 50% Human Human -DTXSID5048683 Css NA 0.2191 mg/L 3compartmentss NA 95% Human Human -DTXSID5048683 Css NA 0.02293 mg/L PBTK NA 50% Human Human -DTXSID5048683 Css NA 0.1467 mg/L PBTK NA 95% Human Human -DTXSID5048683 Clint NA 1668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048683 Fup NA 0.037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048683 Vd NA 2.306 L/kg 1compartment NA NA Rat Human -DTXSID5048683 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048683 TK.Half.Life NA 0.9386 hours 1compartment NA NA Rat Human -DTXSID5048683 Css NA 0.01854 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048683 Css NA 0.1002 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048683 Css NA 0.01226 mg/L PBTK NA 50% Rat Human -DTXSID5048683 Css NA 0.06219 mg/L PBTK NA 95% Rat Human -DTXSID5048685 Clint NA 10.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048685 Fup NA 0.0712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048685 Vd NA 0.5445 L/kg 1compartment NA NA Human Human +DTXSID5048681 TK.Half.Life NA 4.68 hours 1compartment NA NA Rat Human +DTXSID5048681 Css NA 0.06637 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048681 Css NA 0.3952 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048681 Css NA 0.0605 mg/L PBTK NA 50% Rat Human +DTXSID5048681 Css NA 0.2537 mg/L PBTK NA 95% Rat Human +DTXSID5048685 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048685 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048685 Vd NA 2.457 L/kg 1compartment NA NA Human Human DTXSID5048685 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048685 TK.Half.Life NA 3.127 hours 1compartment NA NA Human Human -DTXSID5048685 Css NA 0.8256 mg/L 3compartmentss NA 50% Human Human -DTXSID5048685 Css NA 5.526 mg/L 3compartmentss NA 95% Human Human -DTXSID5048685 Css NA 0.5127 mg/L PBTK NA 50% Human Human -DTXSID5048685 Css NA 3.312 mg/L PBTK NA 95% Human Human -DTXSID5048685 Clint NA 10.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048685 Fup NA 0.0712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048685 Vd NA 0.4591 L/kg 1compartment NA NA Rat Human +DTXSID5048685 TK.Half.Life NA 8.46 hours 1compartment NA NA Human Human +DTXSID5048685 Css NA 0.3107 mg/L 3compartmentss NA 50% Human Human +DTXSID5048685 Css NA 1.774 mg/L 3compartmentss NA 95% Human Human +DTXSID5048685 Css NA 0.2443 mg/L PBTK NA 50% Human Human +DTXSID5048685 Css NA 1.303 mg/L PBTK NA 95% Human Human +DTXSID5048685 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048685 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048685 Vd NA 1.917 L/kg 1compartment NA NA Rat Human DTXSID5048685 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048685 TK.Half.Life NA 1.618 hours 1compartment NA NA Rat Human -DTXSID5048685 Css NA 0.448 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048685 Css NA 2.189 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048685 Css NA 0.26 mg/L PBTK NA 50% Rat Human -DTXSID5048685 Css NA 1.221 mg/L PBTK NA 95% Rat Human +DTXSID5048685 TK.Half.Life NA 2.381 hours 1compartment NA NA Rat Human +DTXSID5048685 Css NA 0.03678 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048685 Css NA 0.1499 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048685 Css NA 0.02901 mg/L PBTK NA 50% Rat Human +DTXSID5048685 Css NA 0.1063 mg/L PBTK NA 95% Rat Human DTXSID5048687 Clint NA 3265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5048687 Fup NA 0.4974 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048687 Vd NA 1.292 L/kg 1compartment NA NA Human Human +DTXSID5048687 Vd NA 1.463 L/kg 1compartment NA NA Human Human DTXSID5048687 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048687 TK.Half.Life NA 0.83 hours 1compartment NA NA Human Human -DTXSID5048687 Css NA 0.0002878 mg/L 3compartmentss NA 50% Human Human -DTXSID5048687 Css NA 0.002802 mg/L 3compartmentss NA 95% Human Human -DTXSID5048687 Css NA 0.000239 mg/L PBTK NA 50% Human Human -DTXSID5048687 Css NA 0.002 mg/L PBTK NA 95% Human Human +DTXSID5048687 TK.Half.Life NA 0.9347 hours 1compartment NA NA Human Human +DTXSID5048687 Css NA 1.678e-05 mg/L 3compartmentss NA 50% Human Human +DTXSID5048687 Css NA 0.0008908 mg/L 3compartmentss NA 95% Human Human +DTXSID5048687 Css NA 1.39e-05 mg/L PBTK NA 50% Human Human +DTXSID5048687 Css NA 0.0006453 mg/L PBTK NA 95% Human Human DTXSID5048687 Clint NA 3265 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5048687 Fup NA 0.4974 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048687 Vd NA 1.132 L/kg 1compartment NA NA Rat Human +DTXSID5048687 Vd NA 1.253 L/kg 1compartment NA NA Rat Human DTXSID5048687 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048687 TK.Half.Life NA 0.3139 hours 1compartment NA NA Rat Human -DTXSID5048687 Css NA 0.0001573 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048687 Css NA 0.001241 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048687 Css NA 0.000126 mg/L PBTK NA 50% Rat Human -DTXSID5048687 Css NA 0.0008756 mg/L PBTK NA 95% Rat Human -DTXSID5048689 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048689 Fup NA 0.1892 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048689 Vd NA 1.98 L/kg 1compartment NA NA Human Human +DTXSID5048687 TK.Half.Life NA 0.3452 hours 1compartment NA NA Rat Human +DTXSID5048687 Css NA 6.84e-07 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048687 Css NA 4.829e-05 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048687 Css NA 5.88e-07 mg/L PBTK NA 50% Rat Human +DTXSID5048687 Css NA 3.444e-05 mg/L PBTK NA 95% Rat Human +DTXSID5048689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048689 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048689 Vd NA 2.189 L/kg 1compartment NA NA Human Human DTXSID5048689 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048689 TK.Half.Life NA 2.199 hours 1compartment NA NA Human Human -DTXSID5048689 Css NA 0.0444 mg/L 3compartmentss NA 50% Human Human -DTXSID5048689 Css NA 0.3064 mg/L 3compartmentss NA 95% Human Human -DTXSID5048689 Css NA 0.03262 mg/L PBTK NA 50% Human Human -DTXSID5048689 Css NA 0.2146 mg/L PBTK NA 95% Human Human -DTXSID5048689 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048689 Fup NA 0.1892 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048689 Vd NA 1.577 L/kg 1compartment NA NA Rat Human +DTXSID5048689 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human +DTXSID5048689 Css NA 0.219 mg/L 3compartmentss NA 50% Human Human +DTXSID5048689 Css NA 1.569 mg/L 3compartmentss NA 95% Human Human +DTXSID5048689 Css NA 0.1551 mg/L PBTK NA 50% Human Human +DTXSID5048689 Css NA 1.05 mg/L PBTK NA 95% Human Human +DTXSID5048689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048689 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048689 Vd NA 1.704 L/kg 1compartment NA NA Rat Human DTXSID5048689 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048689 TK.Half.Life NA 0.7915 hours 1compartment NA NA Rat Human -DTXSID5048689 Css NA 0.02458 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048689 Css NA 0.1373 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048689 Css NA 0.01737 mg/L PBTK NA 50% Rat Human -DTXSID5048689 Css NA 0.0914 mg/L PBTK NA 95% Rat Human -DTXSID5048710 Clint NA 0.9083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048710 Fup NA 0.9382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048710 Vd NA 1.626 L/kg 1compartment NA NA Human Human -DTXSID5048710 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048710 TK.Half.Life NA 4.807 hours 1compartment NA NA Human Human -DTXSID5048710 Css NA 0.3056 mg/L 3compartmentss NA 50% Human Human -DTXSID5048710 Css NA 1.313 mg/L 3compartmentss NA 95% Human Human -DTXSID5048710 Css NA 0.2894 mg/L PBTK NA 50% Human Human -DTXSID5048710 Css NA 1.016 mg/L PBTK NA 95% Human Human -DTXSID5048710 Clint NA 0.9083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048710 Fup NA 0.9382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048710 Vd NA 1.641 L/kg 1compartment NA NA Rat Human +DTXSID5048689 TK.Half.Life NA 1.931 hours 1compartment NA NA Rat Human +DTXSID5048689 Css NA 0.01083 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048689 Css NA 0.08389 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048689 Css NA 0.007587 mg/L PBTK NA 50% Rat Human +DTXSID5048689 Css NA 0.05407 mg/L PBTK NA 95% Rat Human +DTXSID5048710 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048710 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048710 Vd NA 1.276 L/kg 1compartment NA NA Human Human +DTXSID5048710 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5048710 TK.Half.Life NA 14.22 hours 1compartment NA NA Human Human +DTXSID5048710 Css NA 1.148 mg/L 3compartmentss NA 50% Human Human +DTXSID5048710 Css NA 8.193 mg/L 3compartmentss NA 95% Human Human +DTXSID5048710 Css NA 0.9902 mg/L PBTK NA 50% Human Human +DTXSID5048710 Css NA 5.295 mg/L PBTK NA 95% Human Human +DTXSID5048710 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048710 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048710 Vd NA 1.276 L/kg 1compartment NA NA Rat Human DTXSID5048710 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048710 TK.Half.Life NA 2.297 hours 1compartment NA NA Rat Human -DTXSID5048710 Css NA 0.1116 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048710 Css NA 0.4212 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048710 Css NA 0.1061 mg/L PBTK NA 50% Rat Human -DTXSID5048710 Css NA 0.2948 mg/L PBTK NA 95% Rat Human -DTXSID5048712 Clint NA 106.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048712 Fup NA 0.0117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048712 Vd NA 23.6 L/kg 1compartment NA NA Human Human -DTXSID5048712 Days.Css NA 25 Days PBTK NA NA Human Human -DTXSID5048712 TK.Half.Life NA 146.7 hours 1compartment NA NA Human Human -DTXSID5048712 Css NA 0.1974 mg/L 3compartmentss NA 50% Human Human -DTXSID5048712 Css NA 1.204 mg/L 3compartmentss NA 95% Human Human -DTXSID5048712 Css NA 0.4976 mg/L PBTK NA 50% Human Human -DTXSID5048712 Css NA 2.848 mg/L PBTK NA 95% Human Human -DTXSID5048712 Clint NA 106.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048712 Fup NA 0.0117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048712 Vd NA 19.3 L/kg 1compartment NA NA Rat Human -DTXSID5048712 Days.Css NA 16 Days PBTK NA NA Rat Human -DTXSID5048712 TK.Half.Life NA 21.92 hours 1compartment NA NA Rat Human -DTXSID5048712 Css NA 0.1044 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048712 Css NA 0.469 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048712 Css NA 0.2703 mg/L PBTK NA 50% Rat Human -DTXSID5048712 Css NA 1.195 mg/L PBTK NA 95% Rat Human -DTXSID5048714 Clint NA 75.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048714 Fup NA 0.0401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048714 Vd NA 0.1853 L/kg 1compartment NA NA Human Human +DTXSID5048710 TK.Half.Life NA 4.817 hours 1compartment NA NA Rat Human +DTXSID5048710 Css NA 0.06773 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048710 Css NA 0.4606 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048710 Css NA 0.05922 mg/L PBTK NA 50% Rat Human +DTXSID5048710 Css NA 0.2878 mg/L PBTK NA 95% Rat Human +DTXSID5048712 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048712 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048712 Vd NA 4.048 L/kg 1compartment NA NA Human Human +DTXSID5048712 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID5048712 TK.Half.Life NA 122.5 hours 1compartment NA NA Human Human +DTXSID5048712 Css NA 3.159 mg/L 3compartmentss NA 50% Human Human +DTXSID5048712 Css NA 19.48 mg/L 3compartmentss NA 95% Human Human +DTXSID5048712 Css NA 2.374 mg/L PBTK NA 50% Human Human +DTXSID5048712 Css NA 14.42 mg/L PBTK NA 95% Human Human +DTXSID5048712 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048712 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048712 Vd NA 3.064 L/kg 1compartment NA NA Rat Human +DTXSID5048712 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID5048712 TK.Half.Life NA 16.71 hours 1compartment NA NA Rat Human +DTXSID5048712 Css NA 0.4141 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048712 Css NA 2.095 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048712 Css NA 0.309 mg/L PBTK NA 50% Rat Human +DTXSID5048712 Css NA 1.583 mg/L PBTK NA 95% Rat Human +DTXSID5048714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048714 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048714 Vd NA 1.996 L/kg 1compartment NA NA Human Human DTXSID5048714 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048714 TK.Half.Life NA 0.4114 hours 1compartment NA NA Human Human -DTXSID5048714 Css NA 0.2504 mg/L 3compartmentss NA 50% Human Human -DTXSID5048714 Css NA 2.375 mg/L 3compartmentss NA 95% Human Human -DTXSID5048714 Css NA 0.1468 mg/L PBTK NA 50% Human Human -DTXSID5048714 Css NA 1.386 mg/L PBTK NA 95% Human Human -DTXSID5048714 Clint NA 75.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048714 Fup NA 0.0401 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048714 Vd NA 0.1849 L/kg 1compartment NA NA Rat Human +DTXSID5048714 TK.Half.Life NA 2.159 hours 1compartment NA NA Human Human +DTXSID5048714 Css NA 0.0484 mg/L 3compartmentss NA 50% Human Human +DTXSID5048714 Css NA 0.3789 mg/L 3compartmentss NA 95% Human Human +DTXSID5048714 Css NA 0.04155 mg/L PBTK NA 50% Human Human +DTXSID5048714 Css NA 0.2842 mg/L PBTK NA 95% Human Human +DTXSID5048714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048714 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048714 Vd NA 1.716 L/kg 1compartment NA NA Rat Human DTXSID5048714 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048714 TK.Half.Life NA 0.239 hours 1compartment NA NA Rat Human -DTXSID5048714 Css NA 0.1429 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048714 Css NA 1.144 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048714 Css NA 0.07849 mg/L PBTK NA 50% Rat Human -DTXSID5048714 Css NA 0.6232 mg/L PBTK NA 95% Rat Human -DTXSID5048716 Clint NA 29.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048716 Fup NA 0.0249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048716 Vd NA 2.83 L/kg 1compartment NA NA Human Human -DTXSID5048716 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5048716 TK.Half.Life NA 30.75 hours 1compartment NA NA Human Human -DTXSID5048716 Css NA 1.415 mg/L 3compartmentss NA 50% Human Human -DTXSID5048716 Css NA 9.097 mg/L 3compartmentss NA 95% Human Human -DTXSID5048716 Css NA 0.9616 mg/L PBTK NA 50% Human Human -DTXSID5048716 Css NA 5.898 mg/L PBTK NA 95% Human Human -DTXSID5048716 Clint NA 29.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048716 Fup NA 0.0249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048716 Vd NA 2.117 L/kg 1compartment NA NA Rat Human -DTXSID5048716 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5048716 TK.Half.Life NA 5.991 hours 1compartment NA NA Rat Human -DTXSID5048716 Css NA 0.7955 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048716 Css NA 4.428 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048716 Css NA 0.5137 mg/L PBTK NA 50% Rat Human -DTXSID5048716 Css NA 2.769 mg/L PBTK NA 95% Rat Human -DTXSID5048718 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048718 Fup NA 0.5796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048718 Vd NA 0.6267 L/kg 1compartment NA NA Human Human +DTXSID5048714 TK.Half.Life NA 0.8778 hours 1compartment NA NA Rat Human +DTXSID5048714 Css NA 0.005916 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048714 Css NA 0.03876 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048714 Css NA 0.005117 mg/L PBTK NA 50% Rat Human +DTXSID5048714 Css NA 0.02862 mg/L PBTK NA 95% Rat Human +DTXSID5048716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048716 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048716 Vd NA 3.099 L/kg 1compartment NA NA Human Human +DTXSID5048716 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID5048716 TK.Half.Life NA 66.46 hours 1compartment NA NA Human Human +DTXSID5048716 Css NA 1.394 mg/L 3compartmentss NA 50% Human Human +DTXSID5048716 Css NA 9.467 mg/L 3compartmentss NA 95% Human Human +DTXSID5048716 Css NA 0.9671 mg/L PBTK NA 50% Human Human +DTXSID5048716 Css NA 6.357 mg/L PBTK NA 95% Human Human +DTXSID5048716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048716 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048716 Vd NA 2.322 L/kg 1compartment NA NA Rat Human +DTXSID5048716 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID5048716 TK.Half.Life NA 9.358 hours 1compartment NA NA Rat Human +DTXSID5048716 Css NA 0.01502 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048716 Css NA 0.09644 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048716 Css NA 0.01001 mg/L PBTK NA 50% Rat Human +DTXSID5048716 Css NA 0.06195 mg/L PBTK NA 95% Rat Human +DTXSID5048718 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048718 Fup 0.421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048718 Vd NA 0.4939 L/kg 1compartment NA NA Human Human DTXSID5048718 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048718 TK.Half.Life NA 3.872 hours 1compartment NA NA Human Human -DTXSID5048718 Css NA 0.7036 mg/L 3compartmentss NA 50% Human Human -DTXSID5048718 Css NA 4.577 mg/L 3compartmentss NA 95% Human Human -DTXSID5048718 Css NA 0.5364 mg/L PBTK NA 50% Human Human -DTXSID5048718 Css NA 2.894 mg/L PBTK NA 95% Human Human -DTXSID5048718 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048718 Fup NA 0.5796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048718 Vd NA 0.6119 L/kg 1compartment NA NA Rat Human +DTXSID5048718 TK.Half.Life NA 7.589 hours 1compartment NA NA Human Human +DTXSID5048718 Css NA 0.9039 mg/L 3compartmentss NA 50% Human Human +DTXSID5048718 Css NA 4.48 mg/L 3compartmentss NA 95% Human Human +DTXSID5048718 Css NA 0.6752 mg/L PBTK NA 50% Human Human +DTXSID5048718 Css NA 2.831 mg/L PBTK NA 95% Human Human +DTXSID5048718 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048718 Fup 0.421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048718 Vd NA 0.5034 L/kg 1compartment NA NA Rat Human DTXSID5048718 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048718 TK.Half.Life NA 1.657 hours 1compartment NA NA Rat Human -DTXSID5048718 Css NA 0.2482 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048718 Css NA 1.593 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048718 Css NA 0.182 mg/L PBTK NA 50% Rat Human -DTXSID5048718 Css NA 0.9245 mg/L PBTK NA 95% Rat Human -DTXSID5048760 Clint NA 13.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048760 Fup NA 0.1523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048760 Vd NA 3.045 L/kg 1compartment NA NA Human Human -DTXSID5048760 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5048760 TK.Half.Life NA 36.64 hours 1compartment NA NA Human Human -DTXSID5048760 Css NA 1.4 mg/L 3compartmentss NA 50% Human Human -DTXSID5048760 Css NA 8.605 mg/L 3compartmentss NA 95% Human Human -DTXSID5048760 Css NA 0.9898 mg/L PBTK NA 50% Human Human -DTXSID5048760 Css NA 5.854 mg/L PBTK NA 95% Human Human -DTXSID5048760 Clint NA 13.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048760 Fup NA 0.1523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048760 Vd NA 2.299 L/kg 1compartment NA NA Rat Human -DTXSID5048760 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5048760 TK.Half.Life NA 5.981 hours 1compartment NA NA Rat Human -DTXSID5048760 Css NA 0.7743 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048760 Css NA 3.598 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048760 Css NA 0.5241 mg/L PBTK NA 50% Rat Human -DTXSID5048760 Css NA 2.344 mg/L PBTK NA 95% Rat Human -DTXSID5048762 Clint NA 10.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048762 Fup NA 0.3184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048762 Vd NA 3.434 L/kg 1compartment NA NA Human Human +DTXSID5048718 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human +DTXSID5048718 Css NA 0.004948 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048718 Css NA 0.02447 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048718 Css NA 0.003515 mg/L PBTK NA 50% Rat Human +DTXSID5048718 Css NA 0.01477 mg/L PBTK NA 95% Rat Human +DTXSID5048760 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048760 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048760 Vd NA 0.5205 L/kg 1compartment NA NA Human Human +DTXSID5048760 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048760 TK.Half.Life NA 0.7551 hours 1compartment NA NA Human Human +DTXSID5048760 Css NA 0.08224 mg/L 3compartmentss NA 50% Human Human +DTXSID5048760 Css NA 0.604 mg/L 3compartmentss NA 95% Human Human +DTXSID5048760 Css NA 0.05662 mg/L PBTK NA 50% Human Human +DTXSID5048760 Css NA 0.3892 mg/L PBTK NA 95% Human Human +DTXSID5048760 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048760 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048760 Vd NA 0.52 L/kg 1compartment NA NA Rat Human +DTXSID5048760 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048760 TK.Half.Life NA 0.4073 hours 1compartment NA NA Rat Human +DTXSID5048760 Css NA 0.01067 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048760 Css NA 0.05824 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048760 Css NA 0.007198 mg/L PBTK NA 50% Rat Human +DTXSID5048760 Css NA 0.03726 mg/L PBTK NA 95% Rat Human +DTXSID5048762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048762 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048762 Vd NA 2.412 L/kg 1compartment NA NA Human Human DTXSID5048762 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048762 TK.Half.Life NA 6.897 hours 1compartment NA NA Human Human -DTXSID5048762 Css NA 0.1382 mg/L 3compartmentss NA 50% Human Human -DTXSID5048762 Css NA 0.8917 mg/L 3compartmentss NA 95% Human Human -DTXSID5048762 Css NA 0.1344 mg/L PBTK NA 50% Human Human -DTXSID5048762 Css NA 0.752 mg/L PBTK NA 95% Human Human -DTXSID5048762 Clint NA 10.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048762 Fup NA 0.3184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048762 Vd NA 3.111 L/kg 1compartment NA NA Rat Human +DTXSID5048762 TK.Half.Life NA 2.294 hours 1compartment NA NA Human Human +DTXSID5048762 Css NA 0.0375 mg/L 3compartmentss NA 50% Human Human +DTXSID5048762 Css NA 0.3427 mg/L 3compartmentss NA 95% Human Human +DTXSID5048762 Css NA 0.0367 mg/L PBTK NA 50% Human Human +DTXSID5048762 Css NA 0.2806 mg/L PBTK NA 95% Human Human +DTXSID5048762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048762 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048762 Vd NA 2.387 L/kg 1compartment NA NA Rat Human DTXSID5048762 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048762 TK.Half.Life NA 2.734 hours 1compartment NA NA Rat Human -DTXSID5048762 Css NA 0.07026 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048762 Css NA 0.3603 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048762 Css NA 0.06792 mg/L PBTK NA 50% Rat Human -DTXSID5048762 Css NA 0.2978 mg/L PBTK NA 95% Rat Human -DTXSID5048764 Clint NA 17.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048764 Fup NA 0.0274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048764 Vd NA 2.963 L/kg 1compartment NA NA Human Human -DTXSID5048764 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID5048764 TK.Half.Life NA 60.06 hours 1compartment NA NA Human Human -DTXSID5048764 Css NA 2.62 mg/L 3compartmentss NA 50% Human Human -DTXSID5048764 Css NA 17.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5048764 Css NA 1.791 mg/L PBTK NA 50% Human Human -DTXSID5048764 Css NA 11.38 mg/L PBTK NA 95% Human Human -DTXSID5048764 Clint NA 17.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048764 Fup NA 0.0274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048764 Vd NA 2.219 L/kg 1compartment NA NA Rat Human -DTXSID5048764 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5048764 TK.Half.Life NA 9.949 hours 1compartment NA NA Rat Human -DTXSID5048764 Css NA 1.453 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048764 Css NA 7.623 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048764 Css NA 0.9506 mg/L PBTK NA 50% Rat Human -DTXSID5048764 Css NA 4.979 mg/L PBTK NA 95% Rat Human -DTXSID5048766 Clint NA 5.382 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048766 Fup NA 0.2734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048766 Vd NA 2.707 L/kg 1compartment NA NA Human Human -DTXSID5048766 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5048766 TK.Half.Life NA 21.23 hours 1compartment NA NA Human Human -DTXSID5048766 Css NA 0.8555 mg/L 3compartmentss NA 50% Human Human -DTXSID5048766 Css NA 4.346 mg/L 3compartmentss NA 95% Human Human -DTXSID5048766 Css NA 0.6289 mg/L PBTK NA 50% Human Human -DTXSID5048766 Css NA 3.045 mg/L PBTK NA 95% Human Human -DTXSID5048766 Clint NA 5.382 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048766 Fup NA 0.2734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048766 Vd NA 2.064 L/kg 1compartment NA NA Rat Human -DTXSID5048766 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5048766 TK.Half.Life NA 4.655 hours 1compartment NA NA Rat Human -DTXSID5048766 Css NA 0.4374 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048766 Css NA 1.588 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048766 Css NA 0.3095 mg/L PBTK NA 50% Rat Human -DTXSID5048766 Css NA 1.054 mg/L PBTK NA 95% Rat Human -DTXSID5048768 Clint NA 6.706 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048768 Fup NA 0.5958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048768 Vd NA 2.116 L/kg 1compartment NA NA Human Human +DTXSID5048762 TK.Half.Life NA 1.19 hours 1compartment NA NA Rat Human +DTXSID5048762 Css NA 0.004558 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048762 Css NA 0.03171 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048762 Css NA 0.004589 mg/L PBTK NA 50% Rat Human +DTXSID5048762 Css NA 0.02522 mg/L PBTK NA 95% Rat Human +DTXSID5048764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048764 Fup 0.0131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048764 Vd NA 2.939 L/kg 1compartment NA NA Human Human +DTXSID5048764 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID5048764 TK.Half.Life NA 62.33 hours 1compartment NA NA Human Human +DTXSID5048764 Css NA 1.478 mg/L 3compartmentss NA 50% Human Human +DTXSID5048764 Css NA 10.39 mg/L 3compartmentss NA 95% Human Human +DTXSID5048764 Css NA 1.009 mg/L PBTK NA 50% Human Human +DTXSID5048764 Css NA 6.819 mg/L PBTK NA 95% Human Human +DTXSID5048764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048764 Fup 0.0131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048764 Vd NA 2.198 L/kg 1compartment NA NA Rat Human +DTXSID5048764 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID5048764 TK.Half.Life NA 10.56 hours 1compartment NA NA Rat Human +DTXSID5048764 Css NA 0.01622 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048764 Css NA 0.1099 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048764 Css NA 0.01057 mg/L PBTK NA 50% Rat Human +DTXSID5048764 Css NA 0.06969 mg/L PBTK NA 95% Rat Human +DTXSID5048766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048766 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048766 Vd NA 1.227 L/kg 1compartment NA NA Human Human +DTXSID5048766 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048766 TK.Half.Life NA 1.552 hours 1compartment NA NA Human Human +DTXSID5048766 Css NA 0.0647 mg/L 3compartmentss NA 50% Human Human +DTXSID5048766 Css NA 0.461 mg/L 3compartmentss NA 95% Human Human +DTXSID5048766 Css NA 0.04932 mg/L PBTK NA 50% Human Human +DTXSID5048766 Css NA 0.321 mg/L PBTK NA 95% Human Human +DTXSID5048766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048766 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048766 Vd NA 1.028 L/kg 1compartment NA NA Rat Human +DTXSID5048766 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048766 TK.Half.Life NA 0.657 hours 1compartment NA NA Rat Human +DTXSID5048766 Css NA 0.008001 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048766 Css NA 0.04501 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048766 Css NA 0.006092 mg/L PBTK NA 50% Rat Human +DTXSID5048766 Css NA 0.03088 mg/L PBTK NA 95% Rat Human +DTXSID5048768 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048768 Fup 0.647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048768 Vd NA 0.8854 L/kg 1compartment NA NA Human Human DTXSID5048768 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048768 TK.Half.Life NA 2.804 hours 1compartment NA NA Human Human -DTXSID5048768 Css NA 0.08929 mg/L 3compartmentss NA 50% Human Human -DTXSID5048768 Css NA 0.882 mg/L 3compartmentss NA 95% Human Human -DTXSID5048768 Css NA 0.08778 mg/L PBTK NA 50% Human Human -DTXSID5048768 Css NA 0.6459 mg/L PBTK NA 95% Human Human -DTXSID5048768 Clint NA 6.706 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048768 Fup NA 0.5958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048768 Vd NA 2.142 L/kg 1compartment NA NA Rat Human +DTXSID5048768 TK.Half.Life NA 1.246 hours 1compartment NA NA Human Human +DTXSID5048768 Css NA 0.1018 mg/L 3compartmentss NA 50% Human Human +DTXSID5048768 Css NA 0.9331 mg/L 3compartmentss NA 95% Human Human +DTXSID5048768 Css NA 0.08333 mg/L PBTK NA 50% Human Human +DTXSID5048768 Css NA 0.6294 mg/L PBTK NA 95% Human Human +DTXSID5048768 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048768 Fup 0.647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048768 Vd NA 0.8594 L/kg 1compartment NA NA Rat Human DTXSID5048768 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048768 TK.Half.Life NA 1.574 hours 1compartment NA NA Rat Human -DTXSID5048768 Css NA 0.04202 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048768 Css NA 0.3894 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048768 Css NA 0.04163 mg/L PBTK NA 50% Rat Human -DTXSID5048768 Css NA 0.257 mg/L PBTK NA 95% Rat Human -DTXSID5048841 Clint NA 1.468 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048841 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048841 Vd NA 0.5199 L/kg 1compartment NA NA Human Human -DTXSID5048841 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5048841 TK.Half.Life NA 17.01 hours 1compartment NA NA Human Human -DTXSID5048841 Css NA 5.292 mg/L 3compartmentss NA 50% Human Human -DTXSID5048841 Css NA 30.19 mg/L 3compartmentss NA 95% Human Human -DTXSID5048841 Css NA 3.343 mg/L PBTK NA 50% Human Human -DTXSID5048841 Css NA 17.78 mg/L PBTK NA 95% Human Human -DTXSID5048841 Clint NA 1.468 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048841 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048841 Vd NA 0.4413 L/kg 1compartment NA NA Rat Human +DTXSID5048768 TK.Half.Life NA 0.646 hours 1compartment NA NA Rat Human +DTXSID5048768 Css NA 0.0113 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048768 Css NA 0.08989 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048768 Css NA 0.009486 mg/L PBTK NA 50% Rat Human +DTXSID5048768 Css NA 0.05752 mg/L PBTK NA 95% Rat Human +DTXSID5048841 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048841 Fup 0.0626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048841 Vd NA 0.5328 L/kg 1compartment NA NA Human Human +DTXSID5048841 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048841 TK.Half.Life NA 1.899 hours 1compartment NA NA Human Human +DTXSID5048841 Css NA 0.4527 mg/L 3compartmentss NA 50% Human Human +DTXSID5048841 Css NA 3.634 mg/L 3compartmentss NA 95% Human Human +DTXSID5048841 Css NA 0.2864 mg/L PBTK NA 50% Human Human +DTXSID5048841 Css NA 2.218 mg/L PBTK NA 95% Human Human +DTXSID5048841 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048841 Fup 0.0626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048841 Vd NA 0.4532 L/kg 1compartment NA NA Rat Human DTXSID5048841 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048841 TK.Half.Life NA 7.598 hours 1compartment NA NA Rat Human -DTXSID5048841 Css NA 2.382 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048841 Css NA 10.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048841 Css NA 1.411 mg/L PBTK NA 50% Rat Human -DTXSID5048841 Css NA 5.858 mg/L PBTK NA 95% Rat Human -DTXSID5048843 Clint NA 1.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048843 Fup NA 0.168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048843 Vd NA 0.6758 L/kg 1compartment NA NA Human Human +DTXSID5048841 TK.Half.Life NA 0.9835 hours 1compartment NA NA Rat Human +DTXSID5048841 Css NA 0.0588 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048841 Css NA 0.3609 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048841 Css NA 0.03631 mg/L PBTK NA 50% Rat Human +DTXSID5048841 Css NA 0.2145 mg/L PBTK NA 95% Rat Human +DTXSID5048843 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048843 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048843 Vd NA 0.7291 L/kg 1compartment NA NA Human Human DTXSID5048843 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048843 TK.Half.Life NA 7.576 hours 1compartment NA NA Human Human -DTXSID5048843 Css NA 1.359 mg/L 3compartmentss NA 50% Human Human -DTXSID5048843 Css NA 6.002 mg/L 3compartmentss NA 95% Human Human -DTXSID5048843 Css NA 0.9092 mg/L PBTK NA 50% Human Human -DTXSID5048843 Css NA 3.731 mg/L PBTK NA 95% Human Human -DTXSID5048843 Clint NA 1.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048843 Fup NA 0.168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048843 Vd NA 0.5665 L/kg 1compartment NA NA Rat Human +DTXSID5048843 TK.Half.Life NA 2.682 hours 1compartment NA NA Human Human +DTXSID5048843 Css NA 0.366 mg/L 3compartmentss NA 50% Human Human +DTXSID5048843 Css NA 2.139 mg/L 3compartmentss NA 95% Human Human +DTXSID5048843 Css NA 0.2485 mg/L PBTK NA 50% Human Human +DTXSID5048843 Css NA 1.37 mg/L PBTK NA 95% Human Human +DTXSID5048843 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048843 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048843 Vd NA 0.6114 L/kg 1compartment NA NA Rat Human DTXSID5048843 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048843 TK.Half.Life NA 3.287 hours 1compartment NA NA Rat Human -DTXSID5048843 Css NA 0.6038 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048843 Css NA 2.001 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048843 Css NA 0.3804 mg/L PBTK NA 50% Rat Human -DTXSID5048843 Css NA 1.156 mg/L PBTK NA 95% Rat Human -DTXSID5048845 Clint NA 0.6723 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5048843 TK.Half.Life NA 1.283 hours 1compartment NA NA Rat Human +DTXSID5048843 Css NA 0.0442 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048843 Css NA 0.1824 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048843 Css NA 0.02946 mg/L PBTK NA 50% Rat Human +DTXSID5048843 Css NA 0.1136 mg/L PBTK NA 95% Rat Human +DTXSID5048845 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5048845 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5048845 Vd NA 0.614 L/kg 1compartment NA NA Human Human +DTXSID5048845 Vd NA 0.4107 L/kg 1compartment NA NA Human Human DTXSID5048845 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048845 TK.Half.Life NA 2.849 hours 1compartment NA NA Human Human -DTXSID5048845 Css NA 0.5151 mg/L 3compartmentss NA 50% Human Human -DTXSID5048845 Css NA 3.684 mg/L 3compartmentss NA 95% Human Human -DTXSID5048845 Css NA 0.4102 mg/L PBTK NA 50% Human Human -DTXSID5048845 Css NA 2.33 mg/L PBTK NA 95% Human Human -DTXSID5048845 Clint NA 0.6723 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5048845 TK.Half.Life NA 4.151 hours 1compartment NA NA Human Human +DTXSID5048845 Css NA 0.6988 mg/L 3compartmentss NA 50% Human Human +DTXSID5048845 Css NA 4.762 mg/L 3compartmentss NA 95% Human Human +DTXSID5048845 Css NA 0.5028 mg/L PBTK NA 50% Human Human +DTXSID5048845 Css NA 2.92 mg/L PBTK NA 95% Human Human +DTXSID5048845 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5048845 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5048845 Vd NA 0.6405 L/kg 1compartment NA NA Rat Human +DTXSID5048845 Vd NA 0.4318 L/kg 1compartment NA NA Rat Human DTXSID5048845 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048845 TK.Half.Life NA 1.388 hours 1compartment NA NA Rat Human -DTXSID5048845 Css NA 0.189 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048845 Css NA 1.262 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048845 Css NA 0.145 mg/L PBTK NA 50% Rat Human -DTXSID5048845 Css NA 0.7401 mg/L PBTK NA 95% Rat Human -DTXSID5048847 Clint NA 2.001 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5048845 TK.Half.Life NA 1.487 hours 1compartment NA NA Rat Human +DTXSID5048845 Css NA 0.003726 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048845 Css NA 0.02361 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048845 Css NA 0.002587 mg/L PBTK NA 50% Rat Human +DTXSID5048845 Css NA 0.0139 mg/L PBTK NA 95% Rat Human +DTXSID5048847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5048847 Fup 0.51 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5048847 Vd NA 0.7349 L/kg 1compartment NA NA Human Human +DTXSID5048847 Vd NA 2.125 L/kg 1compartment NA NA Human Human DTXSID5048847 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048847 TK.Half.Life NA 2.469 hours 1compartment NA NA Human Human -DTXSID5048847 Css NA 0.3344 mg/L 3compartmentss NA 50% Human Human -DTXSID5048847 Css NA 2.193 mg/L 3compartmentss NA 95% Human Human -DTXSID5048847 Css NA 0.2623 mg/L PBTK NA 50% Human Human -DTXSID5048847 Css NA 1.399 mg/L PBTK NA 95% Human Human -DTXSID5048847 Clint NA 2.001 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5048847 TK.Half.Life NA 2.506 hours 1compartment NA NA Human Human +DTXSID5048847 Css NA 0.05868 mg/L 3compartmentss NA 50% Human Human +DTXSID5048847 Css NA 0.4591 mg/L 3compartmentss NA 95% Human Human +DTXSID5048847 Css NA 0.04866 mg/L PBTK NA 50% Human Human +DTXSID5048847 Css NA 0.3429 mg/L PBTK NA 95% Human Human +DTXSID5048847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5048847 Fup 0.51 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5048847 Vd NA 0.7264 L/kg 1compartment NA NA Rat Human +DTXSID5048847 Vd NA 1.679 L/kg 1compartment NA NA Rat Human DTXSID5048847 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048847 TK.Half.Life NA 1.286 hours 1compartment NA NA Rat Human -DTXSID5048847 Css NA 0.1488 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048847 Css NA 0.787 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048847 Css NA 0.1126 mg/L PBTK NA 50% Rat Human -DTXSID5048847 Css NA 0.4731 mg/L PBTK NA 95% Rat Human -DTXSID5048849 Clint NA 20.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048849 Fup NA 0.0243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048849 Vd NA 2.252 L/kg 1compartment NA NA Human Human -DTXSID5048849 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5048849 TK.Half.Life NA 15.08 hours 1compartment NA NA Human Human -DTXSID5048849 Css NA 0.9326 mg/L 3compartmentss NA 50% Human Human -DTXSID5048849 Css NA 7.625 mg/L 3compartmentss NA 95% Human Human -DTXSID5048849 Css NA 0.6283 mg/L PBTK NA 50% Human Human -DTXSID5048849 Css NA 4.928 mg/L PBTK NA 95% Human Human -DTXSID5048849 Clint NA 20.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048849 Fup NA 0.0243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048849 Vd NA 1.768 L/kg 1compartment NA NA Rat Human +DTXSID5048847 TK.Half.Life NA 0.8452 hours 1compartment NA NA Rat Human +DTXSID5048847 Css NA 0.007236 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048847 Css NA 0.04548 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048847 Css NA 0.006099 mg/L PBTK NA 50% Rat Human +DTXSID5048847 Css NA 0.03337 mg/L PBTK NA 95% Rat Human +DTXSID5048849 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048849 Fup 0.0429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048849 Vd NA 2.67 L/kg 1compartment NA NA Human Human +DTXSID5048849 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048849 TK.Half.Life NA 13.75 hours 1compartment NA NA Human Human +DTXSID5048849 Css NA 0.6023 mg/L 3compartmentss NA 50% Human Human +DTXSID5048849 Css NA 4.608 mg/L 3compartmentss NA 95% Human Human +DTXSID5048849 Css NA 0.4235 mg/L PBTK NA 50% Human Human +DTXSID5048849 Css NA 3.096 mg/L PBTK NA 95% Human Human +DTXSID5048849 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048849 Fup 0.0429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048849 Vd NA 2.109 L/kg 1compartment NA NA Rat Human DTXSID5048849 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048849 TK.Half.Life NA 5.177 hours 1compartment NA NA Rat Human -DTXSID5048849 Css NA 0.517 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048849 Css NA 3.515 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048849 Css NA 0.331 mg/L PBTK NA 50% Rat Human -DTXSID5048849 Css NA 2.065 mg/L PBTK NA 95% Rat Human -DTXSID5048891 Clint NA 26.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048891 Fup NA 0.3855 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048891 Vd NA 1.212 L/kg 1compartment NA NA Human Human +DTXSID5048849 TK.Half.Life NA 4.039 hours 1compartment NA NA Rat Human +DTXSID5048849 Css NA 0.07955 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048849 Css NA 0.4794 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048849 Css NA 0.05525 mg/L PBTK NA 50% Rat Human +DTXSID5048849 Css NA 0.3145 mg/L PBTK NA 95% Rat Human +DTXSID5048891 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048891 Fup 0.503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048891 Vd NA 0.6411 L/kg 1compartment NA NA Human Human DTXSID5048891 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048891 TK.Half.Life NA 1.294 hours 1compartment NA NA Human Human -DTXSID5048891 Css NA 0.04585 mg/L 3compartmentss NA 50% Human Human -DTXSID5048891 Css NA 0.3422 mg/L 3compartmentss NA 95% Human Human -DTXSID5048891 Css NA 0.0357 mg/L PBTK NA 50% Human Human -DTXSID5048891 Css NA 0.2417 mg/L PBTK NA 95% Human Human -DTXSID5048891 Clint NA 26.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048891 Fup NA 0.3855 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048891 Vd NA 1.028 L/kg 1compartment NA NA Rat Human +DTXSID5048891 TK.Half.Life NA 1.1 hours 1compartment NA NA Human Human +DTXSID5048891 Css NA 0.1298 mg/L 3compartmentss NA 50% Human Human +DTXSID5048891 Css NA 0.9938 mg/L 3compartmentss NA 95% Human Human +DTXSID5048891 Css NA 0.09798 mg/L PBTK NA 50% Human Human +DTXSID5048891 Css NA 0.6583 mg/L PBTK NA 95% Human Human +DTXSID5048891 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048891 Fup 0.503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048891 Vd NA 0.6393 L/kg 1compartment NA NA Rat Human DTXSID5048891 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048891 TK.Half.Life NA 0.5411 hours 1compartment NA NA Rat Human -DTXSID5048891 Css NA 0.02488 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048891 Css NA 0.1452 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048891 Css NA 0.01861 mg/L PBTK NA 50% Rat Human -DTXSID5048891 Css NA 0.09644 mg/L PBTK NA 95% Rat Human -DTXSID5048893 Clint NA 135.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048893 Fup NA 0.6675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048893 Vd NA 3.932 L/kg 1compartment NA NA Human Human +DTXSID5048891 TK.Half.Life NA 0.5996 hours 1compartment NA NA Rat Human +DTXSID5048891 Css NA 0.01494 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048891 Css NA 0.09322 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048891 Css NA 0.01142 mg/L PBTK NA 50% Rat Human +DTXSID5048891 Css NA 0.05811 mg/L PBTK NA 95% Rat Human +DTXSID5048893 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048893 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048893 Vd NA 2.479 L/kg 1compartment NA NA Human Human DTXSID5048893 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048893 TK.Half.Life NA 1.507 hours 1compartment NA NA Human Human -DTXSID5048893 Css NA 0.002916 mg/L 3compartmentss NA 50% Human Human -DTXSID5048893 Css NA 0.04219 mg/L 3compartmentss NA 95% Human Human -DTXSID5048893 Css NA 0.004042 mg/L PBTK NA 50% Human Human -DTXSID5048893 Css NA 0.039 mg/L PBTK NA 95% Human Human -DTXSID5048893 Clint NA 135.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048893 Fup NA 0.6675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048893 Vd NA 3.957 L/kg 1compartment NA NA Rat Human +DTXSID5048893 TK.Half.Life NA 4.181 hours 1compartment NA NA Human Human +DTXSID5048893 Css NA 0.101 mg/L 3compartmentss NA 50% Human Human +DTXSID5048893 Css NA 0.8153 mg/L 3compartmentss NA 95% Human Human +DTXSID5048893 Css NA 0.1092 mg/L PBTK NA 50% Human Human +DTXSID5048893 Css NA 0.6799 mg/L PBTK NA 95% Human Human +DTXSID5048893 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048893 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048893 Vd NA 2.475 L/kg 1compartment NA NA Rat Human DTXSID5048893 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048893 TK.Half.Life NA 0.6945 hours 1compartment NA NA Rat Human -DTXSID5048893 Css NA 0.001454 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048893 Css NA 0.01934 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048893 Css NA 0.00211 mg/L PBTK NA 50% Rat Human -DTXSID5048893 Css NA 0.01737 mg/L PBTK NA 95% Rat Human -DTXSID5048895 Clint NA 10 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048895 Fup NA 0.2138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048895 Vd NA 3.901 L/kg 1compartment NA NA Human Human +DTXSID5048893 TK.Half.Life NA 2.412 hours 1compartment NA NA Rat Human +DTXSID5048893 Css NA 0.01131 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048893 Css NA 0.07343 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048893 Css NA 0.01268 mg/L PBTK NA 50% Rat Human +DTXSID5048893 Css NA 0.05827 mg/L PBTK NA 95% Rat Human +DTXSID5048895 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048895 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048895 Vd NA 1.77 L/kg 1compartment NA NA Human Human DTXSID5048895 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048895 TK.Half.Life NA 6.601 hours 1compartment NA NA Human Human -DTXSID5048895 Css NA 0.09329 mg/L 3compartmentss NA 50% Human Human -DTXSID5048895 Css NA 0.7505 mg/L 3compartmentss NA 95% Human Human -DTXSID5048895 Css NA 0.1131 mg/L PBTK NA 50% Human Human -DTXSID5048895 Css NA 0.7007 mg/L PBTK NA 95% Human Human -DTXSID5048895 Clint NA 10 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048895 Fup NA 0.2138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048895 Vd NA 3.915 L/kg 1compartment NA NA Rat Human +DTXSID5048895 TK.Half.Life NA 2.855 hours 1compartment NA NA Human Human +DTXSID5048895 Css NA 0.1074 mg/L 3compartmentss NA 50% Human Human +DTXSID5048895 Css NA 0.9074 mg/L 3compartmentss NA 95% Human Human +DTXSID5048895 Css NA 0.1011 mg/L PBTK NA 50% Human Human +DTXSID5048895 Css NA 0.6657 mg/L PBTK NA 95% Human Human +DTXSID5048895 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048895 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048895 Vd NA 1.785 L/kg 1compartment NA NA Rat Human DTXSID5048895 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048895 TK.Half.Life NA 3.806 hours 1compartment NA NA Rat Human -DTXSID5048895 Css NA 0.04849 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048895 Css NA 0.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048895 Css NA 0.05816 mg/L PBTK NA 50% Rat Human -DTXSID5048895 Css NA 0.2663 mg/L PBTK NA 95% Rat Human -DTXSID5048897 Clint NA 16.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048897 Fup NA 0.1224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048897 Vd NA 3.837 L/kg 1compartment NA NA Human Human +DTXSID5048895 TK.Half.Life NA 1.618 hours 1compartment NA NA Rat Human +DTXSID5048895 Css NA 0.0121 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048895 Css NA 0.08075 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048895 Css NA 0.0116 mg/L PBTK NA 50% Rat Human +DTXSID5048895 Css NA 0.05689 mg/L PBTK NA 95% Rat Human +DTXSID5048897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048897 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048897 Vd NA 4.725 L/kg 1compartment NA NA Human Human DTXSID5048897 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048897 TK.Half.Life NA 6.911 hours 1compartment NA NA Human Human -DTXSID5048897 Css NA 0.1301 mg/L 3compartmentss NA 50% Human Human -DTXSID5048897 Css NA 1.031 mg/L 3compartmentss NA 95% Human Human -DTXSID5048897 Css NA 0.1232 mg/L PBTK NA 50% Human Human -DTXSID5048897 Css NA 0.8411 mg/L PBTK NA 95% Human Human -DTXSID5048897 Clint NA 16.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048897 Fup NA 0.1224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048897 Vd NA 3.461 L/kg 1compartment NA NA Rat Human +DTXSID5048897 TK.Half.Life NA 5.165 hours 1compartment NA NA Human Human +DTXSID5048897 Css NA 0.0469 mg/L 3compartmentss NA 50% Human Human +DTXSID5048897 Css NA 0.3632 mg/L 3compartmentss NA 95% Human Human +DTXSID5048897 Css NA 0.05545 mg/L PBTK NA 50% Human Human +DTXSID5048897 Css NA 0.358 mg/L PBTK NA 95% Human Human +DTXSID5048897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048897 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048897 Vd NA 4.471 L/kg 1compartment NA NA Rat Human DTXSID5048897 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048897 TK.Half.Life NA 2.583 hours 1compartment NA NA Rat Human -DTXSID5048897 Css NA 0.07096 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048897 Css NA 0.4243 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048897 Css NA 0.06572 mg/L PBTK NA 50% Rat Human -DTXSID5048897 Css NA 0.3336 mg/L PBTK NA 95% Rat Human -DTXSID5048899 Clint NA 16.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048899 Fup NA 0.4527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048899 Vd NA 1.603 L/kg 1compartment NA NA Human Human -DTXSID5048899 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048899 TK.Half.Life NA 1.74 hours 1compartment NA NA Human Human -DTXSID5048899 Css NA 0.05338 mg/L 3compartmentss NA 50% Human Human -DTXSID5048899 Css NA 0.4542 mg/L 3compartmentss NA 95% Human Human -DTXSID5048899 Css NA 0.04691 mg/L PBTK NA 50% Human Human -DTXSID5048899 Css NA 0.3414 mg/L PBTK NA 95% Human Human -DTXSID5048899 Clint NA 16.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048899 Fup NA 0.4527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048899 Vd NA 1.562 L/kg 1compartment NA NA Rat Human +DTXSID5048897 TK.Half.Life NA 2.104 hours 1compartment NA NA Rat Human +DTXSID5048897 Css NA 0.005661 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048897 Css NA 0.03342 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048897 Css NA 0.007035 mg/L PBTK NA 50% Rat Human +DTXSID5048897 Css NA 0.03633 mg/L PBTK NA 95% Rat Human +DTXSID5048899 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048899 Fup 0.661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048899 Vd NA 1.157 L/kg 1compartment NA NA Human Human +DTXSID5048899 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5048899 TK.Half.Life NA 12.12 hours 1compartment NA NA Human Human +DTXSID5048899 Css NA 1.076 mg/L 3compartmentss NA 50% Human Human +DTXSID5048899 Css NA 7.011 mg/L 3compartmentss NA 95% Human Human +DTXSID5048899 Css NA 0.9321 mg/L PBTK NA 50% Human Human +DTXSID5048899 Css NA 4.624 mg/L PBTK NA 95% Human Human +DTXSID5048899 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048899 Fup 0.661 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048899 Vd NA 1.059 L/kg 1compartment NA NA Rat Human DTXSID5048899 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048899 TK.Half.Life NA 0.8912 hours 1compartment NA NA Rat Human -DTXSID5048899 Css NA 0.0278 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048899 Css NA 0.1934 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048899 Css NA 0.02389 mg/L PBTK NA 50% Rat Human -DTXSID5048899 Css NA 0.1342 mg/L PBTK NA 95% Rat Human -DTXSID5048920 Clint NA 51.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048920 Fup NA 0.0993 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048920 Vd NA 3.116 L/kg 1compartment NA NA Human Human -DTXSID5048920 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048920 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human -DTXSID5048920 Css NA 0.1418 mg/L 3compartmentss NA 50% Human Human -DTXSID5048920 Css NA 1.047 mg/L 3compartmentss NA 95% Human Human -DTXSID5048920 Css NA 0.1079 mg/L PBTK NA 50% Human Human -DTXSID5048920 Css NA 0.7382 mg/L PBTK NA 95% Human Human -DTXSID5048920 Clint NA 51.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048920 Fup NA 0.0993 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048920 Vd NA 2.536 L/kg 1compartment NA NA Rat Human +DTXSID5048899 TK.Half.Life NA 3.591 hours 1compartment NA NA Rat Human +DTXSID5048899 Css NA 0.06462 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048899 Css NA 0.4141 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048899 Css NA 0.05621 mg/L PBTK NA 50% Rat Human +DTXSID5048899 Css NA 0.2597 mg/L PBTK NA 95% Rat Human +DTXSID5048920 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048920 Fup 0.0472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048920 Vd NA 3.038 L/kg 1compartment NA NA Human Human +DTXSID5048920 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5048920 TK.Half.Life NA 17.04 hours 1compartment NA NA Human Human +DTXSID5048920 Css NA 0.6188 mg/L 3compartmentss NA 50% Human Human +DTXSID5048920 Css NA 4.175 mg/L 3compartmentss NA 95% Human Human +DTXSID5048920 Css NA 0.44 mg/L PBTK NA 50% Human Human +DTXSID5048920 Css NA 2.866 mg/L PBTK NA 95% Human Human +DTXSID5048920 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048920 Fup 0.0472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048920 Vd NA 2.36 L/kg 1compartment NA NA Rat Human DTXSID5048920 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048920 TK.Half.Life NA 1.71 hours 1compartment NA NA Rat Human -DTXSID5048920 Css NA 0.07911 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048920 Css NA 0.4574 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048920 Css NA 0.05864 mg/L PBTK NA 50% Rat Human -DTXSID5048920 Css NA 0.312 mg/L PBTK NA 95% Rat Human -DTXSID5048922 Clint NA 22.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048922 Fup NA 0.0944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048922 Vd NA 2.032 L/kg 1compartment NA NA Human Human +DTXSID5048920 TK.Half.Life NA 3.717 hours 1compartment NA NA Rat Human +DTXSID5048920 Css NA 0.0803 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048920 Css NA 0.4594 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048920 Css NA 0.05676 mg/L PBTK NA 50% Rat Human +DTXSID5048920 Css NA 0.3102 mg/L PBTK NA 95% Rat Human +DTXSID5048922 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048922 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048922 Vd NA 2.487 L/kg 1compartment NA NA Human Human DTXSID5048922 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048922 TK.Half.Life NA 3.986 hours 1compartment NA NA Human Human -DTXSID5048922 Css NA 0.1737 mg/L 3compartmentss NA 50% Human Human -DTXSID5048922 Css NA 1.597 mg/L 3compartmentss NA 95% Human Human -DTXSID5048922 Css NA 0.1426 mg/L PBTK NA 50% Human Human -DTXSID5048922 Css NA 1.11 mg/L PBTK NA 95% Human Human -DTXSID5048922 Clint NA 22.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048922 Fup NA 0.0944 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048922 Vd NA 2.02 L/kg 1compartment NA NA Rat Human +DTXSID5048922 TK.Half.Life NA 3.927 hours 1compartment NA NA Human Human +DTXSID5048922 Css NA 0.1102 mg/L 3compartmentss NA 50% Human Human +DTXSID5048922 Css NA 1.105 mg/L 3compartmentss NA 95% Human Human +DTXSID5048922 Css NA 0.09986 mg/L PBTK NA 50% Human Human +DTXSID5048922 Css NA 0.8306 mg/L PBTK NA 95% Human Human +DTXSID5048922 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048922 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048922 Vd NA 2.486 L/kg 1compartment NA NA Rat Human DTXSID5048922 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048922 TK.Half.Life NA 2.36 hours 1compartment NA NA Rat Human -DTXSID5048922 Css NA 0.09689 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048922 Css NA 0.7072 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048922 Css NA 0.07532 mg/L PBTK NA 50% Rat Human -DTXSID5048922 Css NA 0.4763 mg/L PBTK NA 95% Rat Human -DTXSID5048924 Clint NA 29.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048924 Fup NA 0.0918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048924 Vd NA 3.104 L/kg 1compartment NA NA Human Human -DTXSID5048924 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5048924 TK.Half.Life NA 30.19 hours 1compartment NA NA Human Human -DTXSID5048924 Css NA 1.118 mg/L 3compartmentss NA 50% Human Human -DTXSID5048924 Css NA 7.38 mg/L 3compartmentss NA 95% Human Human -DTXSID5048924 Css NA 0.7869 mg/L PBTK NA 50% Human Human -DTXSID5048924 Css NA 5.053 mg/L PBTK NA 95% Human Human -DTXSID5048924 Clint NA 29.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048924 Fup NA 0.0918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048924 Vd NA 2.345 L/kg 1compartment NA NA Rat Human -DTXSID5048924 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5048924 TK.Half.Life NA 4.8 hours 1compartment NA NA Rat Human -DTXSID5048924 Css NA 0.6236 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048924 Css NA 3.377 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048924 Css NA 0.4208 mg/L PBTK NA 50% Rat Human -DTXSID5048924 Css NA 2.183 mg/L PBTK NA 95% Rat Human -DTXSID5048926 Clint NA 27.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048926 Fup NA 0.0441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048926 Vd NA 2.802 L/kg 1compartment NA NA Human Human +DTXSID5048922 TK.Half.Life NA 2.292 hours 1compartment NA NA Rat Human +DTXSID5048922 Css NA 0.01423 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048922 Css NA 0.1129 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048922 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID5048922 Css NA 0.08218 mg/L PBTK NA 95% Rat Human +DTXSID5048924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048924 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048924 Vd NA 2.219 L/kg 1compartment NA NA Human Human +DTXSID5048924 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048924 TK.Half.Life NA 2.312 hours 1compartment NA NA Human Human +DTXSID5048924 Css NA 0.0442 mg/L 3compartmentss NA 50% Human Human +DTXSID5048924 Css NA 0.392 mg/L 3compartmentss NA 95% Human Human +DTXSID5048924 Css NA 0.04413 mg/L PBTK NA 50% Human Human +DTXSID5048924 Css NA 0.3169 mg/L PBTK NA 95% Human Human +DTXSID5048924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048924 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048924 Vd NA 2.204 L/kg 1compartment NA NA Rat Human +DTXSID5048924 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5048924 TK.Half.Life NA 1.268 hours 1compartment NA NA Rat Human +DTXSID5048924 Css NA 0.005428 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048924 Css NA 0.0361 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048924 Css NA 0.005537 mg/L PBTK NA 50% Rat Human +DTXSID5048924 Css NA 0.02995 mg/L PBTK NA 95% Rat Human +DTXSID5048926 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048926 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048926 Vd NA 1.851 L/kg 1compartment NA NA Human Human DTXSID5048926 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048926 TK.Half.Life NA 4.919 hours 1compartment NA NA Human Human -DTXSID5048926 Css NA 0.146 mg/L 3compartmentss NA 50% Human Human -DTXSID5048926 Css NA 1.347 mg/L 3compartmentss NA 95% Human Human -DTXSID5048926 Css NA 0.1144 mg/L PBTK NA 50% Human Human -DTXSID5048926 Css NA 0.9369 mg/L PBTK NA 95% Human Human -DTXSID5048926 Clint NA 27.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048926 Fup NA 0.0441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048926 Vd NA 2.48 L/kg 1compartment NA NA Rat Human +DTXSID5048926 TK.Half.Life NA 3.052 hours 1compartment NA NA Human Human +DTXSID5048926 Css NA 0.1176 mg/L 3compartmentss NA 50% Human Human +DTXSID5048926 Css NA 1.045 mg/L 3compartmentss NA 95% Human Human +DTXSID5048926 Css NA 0.09567 mg/L PBTK NA 50% Human Human +DTXSID5048926 Css NA 0.7227 mg/L PBTK NA 95% Human Human +DTXSID5048926 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048926 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048926 Vd NA 1.852 L/kg 1compartment NA NA Rat Human DTXSID5048926 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048926 TK.Half.Life NA 2.08 hours 1compartment NA NA Rat Human -DTXSID5048926 Css NA 0.08174 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048926 Css NA 0.6116 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048926 Css NA 0.06219 mg/L PBTK NA 50% Rat Human -DTXSID5048926 Css NA 0.393 mg/L PBTK NA 95% Rat Human -DTXSID5048928 Clint NA 52.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048928 Fup NA 0.0741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048928 Vd NA 2.805 L/kg 1compartment NA NA Human Human +DTXSID5048926 TK.Half.Life NA 1.772 hours 1compartment NA NA Rat Human +DTXSID5048926 Css NA 0.01501 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048926 Css NA 0.1005 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048926 Css NA 0.01216 mg/L PBTK NA 50% Rat Human +DTXSID5048926 Css NA 0.06946 mg/L PBTK NA 95% Rat Human +DTXSID5048928 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048928 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048928 Vd NA 0.4016 L/kg 1compartment NA NA Human Human DTXSID5048928 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048928 TK.Half.Life NA 10.18 hours 1compartment NA NA Human Human -DTXSID5048928 Css NA 0.3814 mg/L 3compartmentss NA 50% Human Human -DTXSID5048928 Css NA 2.509 mg/L 3compartmentss NA 95% Human Human -DTXSID5048928 Css NA 0.2628 mg/L PBTK NA 50% Human Human -DTXSID5048928 Css NA 1.654 mg/L PBTK NA 95% Human Human -DTXSID5048928 Clint NA 52.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048928 Fup NA 0.0741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048928 Vd NA 2.106 L/kg 1compartment NA NA Rat Human +DTXSID5048928 TK.Half.Life NA 0.6829 hours 1compartment NA NA Human Human +DTXSID5048928 Css NA 0.1125 mg/L 3compartmentss NA 50% Human Human +DTXSID5048928 Css NA 0.7997 mg/L 3compartmentss NA 95% Human Human +DTXSID5048928 Css NA 0.0739 mg/L PBTK NA 50% Human Human +DTXSID5048928 Css NA 0.5021 mg/L PBTK NA 95% Human Human +DTXSID5048928 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048928 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048928 Vd NA 0.3975 L/kg 1compartment NA NA Rat Human DTXSID5048928 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048928 TK.Half.Life NA 2.267 hours 1compartment NA NA Rat Human -DTXSID5048928 Css NA 0.2147 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048928 Css NA 1.123 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048928 Css NA 0.1409 mg/L PBTK NA 50% Rat Human -DTXSID5048928 Css NA 0.7122 mg/L PBTK NA 95% Rat Human -DTXSID5048970 Clint NA 163.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048970 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048970 Vd NA 73.72 L/kg 1compartment NA NA Human Human -DTXSID5048970 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID5048970 TK.Half.Life NA 59.04 hours 1compartment NA NA Human Human -DTXSID5048970 Css NA 0.008175 mg/L 3compartmentss NA 50% Human Human -DTXSID5048970 Css NA 0.06883 mg/L 3compartmentss NA 95% Human Human -DTXSID5048970 Css NA 0.06682 mg/L PBTK NA 50% Human Human -DTXSID5048970 Css NA 0.4045 mg/L PBTK NA 95% Human Human -DTXSID5048970 Clint NA 163.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048970 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048970 Vd NA 63.09 L/kg 1compartment NA NA Rat Human -DTXSID5048970 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID5048970 TK.Half.Life NA 10.73 hours 1compartment NA NA Rat Human -DTXSID5048970 Css NA 0.003996 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048970 Css NA 0.02981 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048970 Css NA 0.03554 mg/L PBTK NA 50% Rat Human -DTXSID5048970 Css NA 0.1856 mg/L PBTK NA 95% Rat Human +DTXSID5048928 TK.Half.Life NA 0.3745 hours 1compartment NA NA Rat Human +DTXSID5048928 Css NA 0.01445 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048928 Css NA 0.07612 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048928 Css NA 0.009368 mg/L PBTK NA 50% Rat Human +DTXSID5048928 Css NA 0.04714 mg/L PBTK NA 95% Rat Human +DTXSID5048970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048970 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048970 Vd NA 3.133 L/kg 1compartment NA NA Human Human +DTXSID5048970 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID5048970 TK.Half.Life NA 90.11 hours 1compartment NA NA Human Human +DTXSID5048970 Css NA 3.313 mg/L 3compartmentss NA 50% Human Human +DTXSID5048970 Css NA 20.15 mg/L 3compartmentss NA 95% Human Human +DTXSID5048970 Css NA 2.306 mg/L PBTK NA 50% Human Human +DTXSID5048970 Css NA 13.85 mg/L PBTK NA 95% Human Human +DTXSID5048970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048970 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048970 Vd NA 2.348 L/kg 1compartment NA NA Rat Human +DTXSID5048970 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID5048970 TK.Half.Life NA 11.87 hours 1compartment NA NA Rat Human +DTXSID5048970 Css NA 0.4322 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048970 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048970 Css NA 0.2988 mg/L PBTK NA 50% Rat Human +DTXSID5048970 Css NA 1.551 mg/L PBTK NA 95% Rat Human DTXSID5048972 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5048972 Fup NA 0.8094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048972 Vd NA 1.381 L/kg 1compartment NA NA Human Human -DTXSID5048972 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5048972 TK.Half.Life NA 11.04 hours 1compartment NA NA Human Human -DTXSID5048972 Css NA 0.8685 mg/L 3compartmentss NA 50% Human Human -DTXSID5048972 Css NA 5.486 mg/L 3compartmentss NA 95% Human Human -DTXSID5048972 Css NA 0.8122 mg/L PBTK NA 50% Human Human -DTXSID5048972 Css NA 3.696 mg/L PBTK NA 95% Human Human +DTXSID5048972 Vd NA 0.5815 L/kg 1compartment NA NA Human Human +DTXSID5048972 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5048972 TK.Half.Life NA 4.649 hours 1compartment NA NA Human Human +DTXSID5048972 Css NA 0.8717 mg/L 3compartmentss NA 50% Human Human +DTXSID5048972 Css NA 5.072 mg/L 3compartmentss NA 95% Human Human +DTXSID5048972 Css NA 0.6908 mg/L PBTK NA 50% Human Human +DTXSID5048972 Css NA 3.222 mg/L PBTK NA 95% Human Human DTXSID5048972 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5048972 Fup NA 0.8094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048972 Vd NA 1.425 L/kg 1compartment NA NA Rat Human +DTXSID5048972 Vd NA 0.6212 L/kg 1compartment NA NA Rat Human DTXSID5048972 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048972 TK.Half.Life NA 3.881 hours 1compartment NA NA Rat Human -DTXSID5048972 Css NA 0.218 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048972 Css NA 1.428 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048972 Css NA 0.2006 mg/L PBTK NA 50% Rat Human -DTXSID5048972 Css NA 0.8932 mg/L PBTK NA 95% Rat Human -DTXSID5048974 Clint NA 36.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048974 Fup NA 0.0617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048974 Vd NA 1.467 L/kg 1compartment NA NA Human Human -DTXSID5048974 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048974 TK.Half.Life NA 4.049 hours 1compartment NA NA Human Human -DTXSID5048974 Css NA 0.3136 mg/L 3compartmentss NA 50% Human Human -DTXSID5048974 Css NA 2.289 mg/L 3compartmentss NA 95% Human Human -DTXSID5048974 Css NA 0.2029 mg/L PBTK NA 50% Human Human -DTXSID5048974 Css NA 1.408 mg/L PBTK NA 95% Human Human -DTXSID5048974 Clint NA 36.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048974 Fup NA 0.0617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048974 Vd NA 1.108 L/kg 1compartment NA NA Rat Human -DTXSID5048974 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048974 TK.Half.Life NA 1.557 hours 1compartment NA NA Rat Human -DTXSID5048974 Css NA 0.177 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048974 Css NA 1.009 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048974 Css NA 0.1076 mg/L PBTK NA 50% Rat Human -DTXSID5048974 Css NA 0.59 mg/L PBTK NA 95% Rat Human +DTXSID5048972 TK.Half.Life NA 1.692 hours 1compartment NA NA Rat Human +DTXSID5048972 Css NA 0.01625 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048972 Css NA 0.1187 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048972 Css NA 0.01234 mg/L PBTK NA 50% Rat Human +DTXSID5048972 Css NA 0.0762 mg/L PBTK NA 95% Rat Human +DTXSID5048974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048974 Fup 0.0317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5048974 Vd NA 2.527 L/kg 1compartment NA NA Human Human +DTXSID5048974 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5048974 TK.Half.Life NA 24.44 hours 1compartment NA NA Human Human +DTXSID5048974 Css NA 1.145 mg/L 3compartmentss NA 50% Human Human +DTXSID5048974 Css NA 8.339 mg/L 3compartmentss NA 95% Human Human +DTXSID5048974 Css NA 0.7653 mg/L PBTK NA 50% Human Human +DTXSID5048974 Css NA 5.3 mg/L PBTK NA 95% Human Human +DTXSID5048974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048974 Fup 0.0317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5048974 Vd NA 1.889 L/kg 1compartment NA NA Rat Human +DTXSID5048974 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5048974 TK.Half.Life NA 6.001 hours 1compartment NA NA Rat Human +DTXSID5048974 Css NA 0.05816 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048974 Css NA 0.4246 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048974 Css NA 0.03765 mg/L PBTK NA 50% Rat Human +DTXSID5048974 Css NA 0.2639 mg/L PBTK NA 95% Rat Human DTXSID5048976 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5048976 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5048976 Vd NA 0.6942 L/kg 1compartment NA NA Human Human +DTXSID5048976 Vd NA 0.6909 L/kg 1compartment NA NA Human Human DTXSID5048976 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5048976 TK.Half.Life NA 4.492 hours 1compartment NA NA Human Human -DTXSID5048976 Css NA 0.8465 mg/L 3compartmentss NA 50% Human Human -DTXSID5048976 Css NA 5.575 mg/L 3compartmentss NA 95% Human Human -DTXSID5048976 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID5048976 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID5048976 TK.Half.Life NA 4.472 hours 1compartment NA NA Human Human +DTXSID5048976 Css NA 0.7143 mg/L 3compartmentss NA 50% Human Human +DTXSID5048976 Css NA 5.07 mg/L 3compartmentss NA 95% Human Human +DTXSID5048976 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID5048976 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID5048976 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5048976 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5048976 Vd NA 0.7452 L/kg 1compartment NA NA Rat Human +DTXSID5048976 Vd NA 0.7425 L/kg 1compartment NA NA Rat Human DTXSID5048976 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5048976 TK.Half.Life NA 1.643 hours 1compartment NA NA Rat Human -DTXSID5048976 Css NA 0.2127 mg/L 3compartmentss NA 50% Rat Human -DTXSID5048976 Css NA 1.338 mg/L 3compartmentss NA 95% Rat Human -DTXSID5048976 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID5048976 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5049021 Clint NA 23.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049021 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049021 Vd NA 3.597 L/kg 1compartment NA NA Human Human +DTXSID5048976 TK.Half.Life NA 1.637 hours 1compartment NA NA Rat Human +DTXSID5048976 Css NA 0.01311 mg/L 3compartmentss NA 50% Rat Human +DTXSID5048976 Css NA 0.1002 mg/L 3compartmentss NA 95% Rat Human +DTXSID5048976 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID5048976 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID5049021 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049021 Fup 0.0121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049021 Vd NA 2.999 L/kg 1compartment NA NA Human Human DTXSID5049021 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5049021 TK.Half.Life NA 12.21 hours 1compartment NA NA Human Human -DTXSID5049021 Css NA 0.3662 mg/L 3compartmentss NA 50% Human Human -DTXSID5049021 Css NA 2.899 mg/L 3compartmentss NA 95% Human Human -DTXSID5049021 Css NA 0.2652 mg/L PBTK NA 50% Human Human -DTXSID5049021 Css NA 1.951 mg/L PBTK NA 95% Human Human -DTXSID5049021 Clint NA 23.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049021 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049021 Vd NA 2.758 L/kg 1compartment NA NA Rat Human +DTXSID5049021 TK.Half.Life NA 9.264 hours 1compartment NA NA Human Human +DTXSID5049021 Css NA 0.298 mg/L 3compartmentss NA 50% Human Human +DTXSID5049021 Css NA 2.232 mg/L 3compartmentss NA 95% Human Human +DTXSID5049021 Css NA 0.2098 mg/L PBTK NA 50% Human Human +DTXSID5049021 Css NA 1.489 mg/L PBTK NA 95% Human Human +DTXSID5049021 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049021 Fup 0.0121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049021 Vd NA 2.301 L/kg 1compartment NA NA Rat Human DTXSID5049021 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049021 TK.Half.Life NA 3.331 hours 1compartment NA NA Rat Human -DTXSID5049021 Css NA 0.2058 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049021 Css NA 1.372 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049021 Css NA 0.1427 mg/L PBTK NA 50% Rat Human -DTXSID5049021 Css NA 0.8993 mg/L PBTK NA 95% Rat Human -DTXSID5049023 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049023 Fup NA 0.7133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049023 Vd NA 0.5883 L/kg 1compartment NA NA Human Human -DTXSID5049023 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5049023 TK.Half.Life NA 5.336 hours 1compartment NA NA Human Human -DTXSID5049023 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human -DTXSID5049023 Css NA 7.144 mg/L 3compartmentss NA 95% Human Human -DTXSID5049023 Css NA 0.8702 mg/L PBTK NA 50% Human Human -DTXSID5049023 Css NA 4.461 mg/L PBTK NA 95% Human Human -DTXSID5049023 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049023 Fup NA 0.7133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049023 Vd NA 0.6261 L/kg 1compartment NA NA Rat Human -DTXSID5049023 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049023 TK.Half.Life NA 1.936 hours 1compartment NA NA Rat Human -DTXSID5049023 Css NA 0.29 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049023 Css NA 1.767 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049023 Css NA 0.219 mg/L PBTK NA 50% Rat Human -DTXSID5049023 Css NA 1.035 mg/L PBTK NA 95% Rat Human -DTXSID5049025 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049025 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049025 Vd NA 0.45 L/kg 1compartment NA NA Human Human -DTXSID5049025 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID5049025 TK.Half.Life NA 58.2 hours 1compartment NA NA Human Human -DTXSID5049025 Css NA 21.18 mg/L 3compartmentss NA 50% Human Human -DTXSID5049025 Css NA 102.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5049025 Css NA 12.84 mg/L PBTK NA 50% Human Human -DTXSID5049025 Css NA 60.24 mg/L PBTK NA 95% Human Human -DTXSID5049025 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049025 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049025 Vd NA 0.3703 L/kg 1compartment NA NA Rat Human -DTXSID5049025 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5049025 TK.Half.Life NA 16.01 hours 1compartment NA NA Rat Human -DTXSID5049025 Css NA 6.035 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049025 Css NA 24.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049025 Css NA 3.426 mg/L PBTK NA 50% Rat Human -DTXSID5049025 Css NA 13.51 mg/L PBTK NA 95% Rat Human -DTXSID5049027 Clint NA 5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049027 Fup NA 0.9412 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049027 Vd NA 3.42 L/kg 1compartment NA NA Human Human -DTXSID5049027 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID5049027 TK.Half.Life NA 61.39 hours 1compartment NA NA Human Human -DTXSID5049027 Css NA 1.936 mg/L 3compartmentss NA 50% Human Human -DTXSID5049027 Css NA 11.99 mg/L 3compartmentss NA 95% Human Human -DTXSID5049027 Css NA 1.462 mg/L PBTK NA 50% Human Human -DTXSID5049027 Css NA 8.553 mg/L PBTK NA 95% Human Human -DTXSID5049027 Clint NA 5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049027 Fup NA 0.9412 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049027 Vd NA 2.673 L/kg 1compartment NA NA Rat Human -DTXSID5049027 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID5049027 TK.Half.Life NA 8.534 hours 1compartment NA NA Rat Human -DTXSID5049027 Css NA 1.043 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049027 Css NA 4.766 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049027 Css NA 0.7636 mg/L PBTK NA 50% Rat Human -DTXSID5049027 Css NA 3.342 mg/L PBTK NA 95% Rat Human -DTXSID5049029 Clint NA 3.685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049029 Fup NA 0.0824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049029 Vd NA 1.077 L/kg 1compartment NA NA Human Human -DTXSID5049029 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5049029 TK.Half.Life NA 13.28 hours 1compartment NA NA Human Human -DTXSID5049029 Css NA 1.896 mg/L 3compartmentss NA 50% Human Human -DTXSID5049029 Css NA 11.53 mg/L 3compartmentss NA 95% Human Human -DTXSID5049029 Css NA 1.218 mg/L PBTK NA 50% Human Human -DTXSID5049029 Css NA 6.958 mg/L PBTK NA 95% Human Human -DTXSID5049029 Clint NA 3.685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049029 Fup NA 0.0824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049029 Vd NA 0.8326 L/kg 1compartment NA NA Rat Human +DTXSID5049021 TK.Half.Life NA 2.103 hours 1compartment NA NA Rat Human +DTXSID5049021 Css NA 0.03917 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049021 Css NA 0.2436 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049021 Css NA 0.02706 mg/L PBTK NA 50% Rat Human +DTXSID5049021 Css NA 0.1622 mg/L PBTK NA 95% Rat Human +DTXSID5049025 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049025 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049025 Vd NA 0.5477 L/kg 1compartment NA NA Human Human +DTXSID5049025 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5049025 TK.Half.Life NA 15.07 hours 1compartment NA NA Human Human +DTXSID5049025 Css NA 2.741 mg/L 3compartmentss NA 50% Human Human +DTXSID5049025 Css NA 10.6 mg/L 3compartmentss NA 95% Human Human +DTXSID5049025 Css NA 1.882 mg/L PBTK NA 50% Human Human +DTXSID5049025 Css NA 6.549 mg/L PBTK NA 95% Human Human +DTXSID5049025 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049025 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049025 Vd NA 0.4934 L/kg 1compartment NA NA Rat Human +DTXSID5049025 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5049025 TK.Half.Life NA 4.557 hours 1compartment NA NA Rat Human +DTXSID5049025 Css NA 0.05002 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049025 Css NA 0.2906 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049025 Css NA 0.03294 mg/L PBTK NA 50% Rat Human +DTXSID5049025 Css NA 0.1787 mg/L PBTK NA 95% Rat Human +DTXSID5049029 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049029 Fup 0.0965 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049029 Vd NA 1.166 L/kg 1compartment NA NA Human Human +DTXSID5049029 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5049029 TK.Half.Life NA 8.255 hours 1compartment NA NA Human Human +DTXSID5049029 Css NA 0.8664 mg/L 3compartmentss NA 50% Human Human +DTXSID5049029 Css NA 5.909 mg/L 3compartmentss NA 95% Human Human +DTXSID5049029 Css NA 0.5601 mg/L PBTK NA 50% Human Human +DTXSID5049029 Css NA 3.705 mg/L PBTK NA 95% Human Human +DTXSID5049029 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049029 Fup 0.0965 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049029 Vd NA 0.9023 L/kg 1compartment NA NA Rat Human DTXSID5049029 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049029 TK.Half.Life NA 5.506 hours 1compartment NA NA Rat Human -DTXSID5049029 Css NA 0.9588 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049029 Css NA 4.328 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049029 Css NA 0.5786 mg/L PBTK NA 50% Rat Human -DTXSID5049029 Css NA 2.426 mg/L PBTK NA 95% Rat Human -DTXSID5049071 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049071 Fup NA 0.0302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049071 Vd NA 2.657 L/kg 1compartment NA NA Human Human -DTXSID5049071 Days.Css NA 390 Days PBTK NA NA Human Human -DTXSID5049071 TK.Half.Life NA 1497 hours 1compartment NA NA Human Human -DTXSID5049071 Css NA 74.78 mg/L 3compartmentss NA 50% Human Human -DTXSID5049071 Css NA 301.5 mg/L 3compartmentss NA 95% Human Human -DTXSID5049071 Css NA 52.44 mg/L PBTK NA 50% Human Human -DTXSID5049071 Css NA 186.2 mg/L PBTK NA 95% Human Human -DTXSID5049071 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049071 Fup NA 0.0302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049071 Vd NA 2.099 L/kg 1compartment NA NA Rat Human -DTXSID5049071 Days.Css NA 102 Days PBTK NA NA Rat Human -DTXSID5049071 TK.Half.Life NA 212.9 hours 1compartment NA NA Rat Human -DTXSID5049071 Css NA 20.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049071 Css NA 70.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049071 Css NA 13.59 mg/L PBTK NA 50% Rat Human -DTXSID5049071 Css NA 40.94 mg/L PBTK NA 95% Rat Human -DTXSID5049073 Clint NA 12.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049073 Fup NA 0.0303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049073 Vd NA 2.915 L/kg 1compartment NA NA Human Human -DTXSID5049073 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID5049073 TK.Half.Life NA 74.84 hours 1compartment NA NA Human Human -DTXSID5049073 Css NA 3.375 mg/L 3compartmentss NA 50% Human Human -DTXSID5049073 Css NA 21.49 mg/L 3compartmentss NA 95% Human Human -DTXSID5049073 Css NA 2.308 mg/L PBTK NA 50% Human Human -DTXSID5049073 Css NA 13.89 mg/L PBTK NA 95% Human Human -DTXSID5049073 Clint NA 12.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049073 Fup NA 0.0303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049073 Vd NA 2.183 L/kg 1compartment NA NA Rat Human -DTXSID5049073 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID5049073 TK.Half.Life NA 12.89 hours 1compartment NA NA Rat Human -DTXSID5049073 Css NA 1.877 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049073 Css NA 9.612 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049073 Css NA 1.22 mg/L PBTK NA 50% Rat Human -DTXSID5049073 Css NA 6.109 mg/L PBTK NA 95% Rat Human -DTXSID5049075 Clint NA 2.583 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049075 Fup NA 0.2558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049075 Vd NA 0.7312 L/kg 1compartment NA NA Human Human +DTXSID5049029 TK.Half.Life NA 3.471 hours 1compartment NA NA Rat Human +DTXSID5049029 Css NA 0.03979 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049029 Css NA 0.2924 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049029 Css NA 0.0252 mg/L PBTK NA 50% Rat Human +DTXSID5049029 Css NA 0.1761 mg/L PBTK NA 95% Rat Human +DTXSID5049071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049071 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049071 Vd NA 1.82 L/kg 1compartment NA NA Human Human +DTXSID5049071 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5049071 TK.Half.Life NA 13.56 hours 1compartment NA NA Human Human +DTXSID5049071 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human +DTXSID5049071 Css NA 9.636 mg/L 3compartmentss NA 95% Human Human +DTXSID5049071 Css NA 0.7051 mg/L PBTK NA 50% Human Human +DTXSID5049071 Css NA 5.955 mg/L PBTK NA 95% Human Human +DTXSID5049071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049071 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049071 Vd NA 1.442 L/kg 1compartment NA NA Rat Human +DTXSID5049071 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5049071 TK.Half.Life NA 5.514 hours 1compartment NA NA Rat Human +DTXSID5049071 Css NA 0.1422 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049071 Css NA 1.079 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049071 Css NA 0.09064 mg/L PBTK NA 50% Rat Human +DTXSID5049071 Css NA 0.65 mg/L PBTK NA 95% Rat Human +DTXSID5049073 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049073 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049073 Vd NA 0.3889 L/kg 1compartment NA NA Human Human +DTXSID5049073 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5049073 TK.Half.Life NA 3.97 hours 1compartment NA NA Human Human +DTXSID5049073 Css NA 1.699 mg/L 3compartmentss NA 50% Human Human +DTXSID5049073 Css NA 16.43 mg/L 3compartmentss NA 95% Human Human +DTXSID5049073 Css NA 1.015 mg/L PBTK NA 50% Human Human +DTXSID5049073 Css NA 9.702 mg/L PBTK NA 95% Human Human +DTXSID5049073 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049073 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049073 Vd NA 0.3149 L/kg 1compartment NA NA Rat Human +DTXSID5049073 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5049073 TK.Half.Life NA 2.093 hours 1compartment NA NA Rat Human +DTXSID5049073 Css NA 0.2308 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049073 Css NA 1.76 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049073 Css NA 0.1315 mg/L PBTK NA 50% Rat Human +DTXSID5049073 Css NA 0.9912 mg/L PBTK NA 95% Rat Human +DTXSID5049075 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049075 Fup 0.551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049075 Vd NA 1.114 L/kg 1compartment NA NA Human Human DTXSID5049075 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5049075 TK.Half.Life NA 3.881 hours 1compartment NA NA Human Human -DTXSID5049075 Css NA 0.5701 mg/L 3compartmentss NA 50% Human Human -DTXSID5049075 Css NA 2.988 mg/L 3compartmentss NA 95% Human Human -DTXSID5049075 Css NA 0.4058 mg/L PBTK NA 50% Human Human -DTXSID5049075 Css NA 1.918 mg/L PBTK NA 95% Human Human -DTXSID5049075 Clint NA 2.583 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049075 Fup NA 0.2558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049075 Vd NA 0.7357 L/kg 1compartment NA NA Rat Human +DTXSID5049075 TK.Half.Life NA 1.731 hours 1compartment NA NA Human Human +DTXSID5049075 Css NA 0.05588 mg/L 3compartmentss NA 50% Human Human +DTXSID5049075 Css NA 0.5761 mg/L 3compartmentss NA 95% Human Human +DTXSID5049075 Css NA 0.04698 mg/L PBTK NA 50% Human Human +DTXSID5049075 Css NA 0.3972 mg/L PBTK NA 95% Human Human +DTXSID5049075 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049075 Fup 0.551 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049075 Vd NA 1.132 L/kg 1compartment NA NA Rat Human DTXSID5049075 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049075 TK.Half.Life NA 2.176 hours 1compartment NA NA Rat Human -DTXSID5049075 Css NA 0.2678 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049075 Css NA 1.016 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049075 Css NA 0.1826 mg/L PBTK NA 50% Rat Human -DTXSID5049075 Css NA 0.6106 mg/L PBTK NA 95% Rat Human -DTXSID5049077 Clint NA 0.2917 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049077 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049077 Vd NA 0.2412 L/kg 1compartment NA NA Human Human -DTXSID5049077 Days.Css NA 52 Days PBTK NA NA Human Human -DTXSID5049077 TK.Half.Life NA 218.6 hours 1compartment NA NA Human Human -DTXSID5049077 Css NA 152.4 mg/L 3compartmentss NA 50% Human Human -DTXSID5049077 Css NA 940.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5049077 Css NA 89.34 mg/L PBTK NA 50% Human Human -DTXSID5049077 Css NA 550.9 mg/L PBTK NA 95% Human Human -DTXSID5049077 Clint NA 0.2917 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049077 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049077 Vd NA 0.2103 L/kg 1compartment NA NA Rat Human -DTXSID5049077 Days.Css NA 16 Days PBTK NA NA Rat Human -DTXSID5049077 TK.Half.Life NA 78.67 hours 1compartment NA NA Rat Human -DTXSID5049077 Css NA 53.88 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049077 Css NA 300.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049077 Css NA 29.35 mg/L PBTK NA 50% Rat Human -DTXSID5049077 Css NA 162.3 mg/L PBTK NA 95% Rat Human +DTXSID5049075 TK.Half.Life NA 0.9659 hours 1compartment NA NA Rat Human +DTXSID5049075 Css NA 0.0005072 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049075 Css NA 0.005131 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049075 Css NA 0.0004166 mg/L PBTK NA 50% Rat Human +DTXSID5049075 Css NA 0.003241 mg/L PBTK NA 95% Rat Human +DTXSID5049077 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049077 Fup 0.0206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049077 Vd NA 0.2954 L/kg 1compartment NA NA Human Human +DTXSID5049077 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5049077 TK.Half.Life NA 2.721 hours 1compartment NA NA Human Human +DTXSID5049077 Css NA 1.521 mg/L 3compartmentss NA 50% Human Human +DTXSID5049077 Css NA 14.64 mg/L 3compartmentss NA 95% Human Human +DTXSID5049077 Css NA 0.9277 mg/L PBTK NA 50% Human Human +DTXSID5049077 Css NA 8.728 mg/L PBTK NA 95% Human Human +DTXSID5049077 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049077 Fup 0.0206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049077 Vd NA 0.2778 L/kg 1compartment NA NA Rat Human +DTXSID5049077 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5049077 TK.Half.Life NA 1.679 hours 1compartment NA NA Rat Human +DTXSID5049077 Css NA 0.1972 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049077 Css NA 1.596 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049077 Css NA 0.1155 mg/L PBTK NA 50% Rat Human +DTXSID5049077 Css NA 0.9086 mg/L PBTK NA 95% Rat Human DTXSID5049079 Clint NA 1665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5049079 Fup NA 0.4165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049079 Vd NA 1.053 L/kg 1compartment NA NA Human Human +DTXSID5049079 Vd NA 0.6524 L/kg 1compartment NA NA Human Human DTXSID5049079 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5049079 TK.Half.Life NA 0.6998 hours 1compartment NA NA Human Human -DTXSID5049079 Css NA 0.0006205 mg/L 3compartmentss NA 50% Human Human -DTXSID5049079 Css NA 0.005464 mg/L 3compartmentss NA 95% Human Human -DTXSID5049079 Css NA 0.0004998 mg/L PBTK NA 50% Human Human -DTXSID5049079 Css NA 0.003831 mg/L PBTK NA 95% Human Human +DTXSID5049079 TK.Half.Life NA 0.4702 hours 1compartment NA NA Human Human +DTXSID5049079 Css NA 6.144e-05 mg/L 3compartmentss NA 50% Human Human +DTXSID5049079 Css NA 0.00246 mg/L 3compartmentss NA 95% Human Human +DTXSID5049079 Css NA 4.585e-05 mg/L PBTK NA 50% Human Human +DTXSID5049079 Css NA 0.001652 mg/L PBTK NA 95% Human Human DTXSID5049079 Clint NA 1665 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5049079 Fup NA 0.4165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049079 Vd NA 1.033 L/kg 1compartment NA NA Rat Human +DTXSID5049079 Vd NA 0.6373 L/kg 1compartment NA NA Rat Human DTXSID5049079 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049079 TK.Half.Life NA 0.2989 hours 1compartment NA NA Rat Human -DTXSID5049079 Css NA 0.0003352 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049079 Css NA 0.002561 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049079 Css NA 0.000263 mg/L PBTK NA 50% Rat Human -DTXSID5049079 Css NA 0.001776 mg/L PBTK NA 95% Rat Human -DTXSID5049235 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049235 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049235 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID5049235 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5049235 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID5049235 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID5049235 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID5049235 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID5049235 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID5049235 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049235 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049235 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID5049235 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049235 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID5049235 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049235 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049235 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID5049235 Css NA 5.483 mg/L PBTK NA 95% Rat Human +DTXSID5049079 TK.Half.Life NA 0.1997 hours 1compartment NA NA Rat Human +DTXSID5049079 Css NA 1.752e-06 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049079 Css NA 9.664e-05 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049079 Css NA 1.301e-06 mg/L PBTK NA 50% Rat Human +DTXSID5049079 Css NA 6.336e-05 mg/L PBTK NA 95% Rat Human DTXSID5049239 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5049239 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049239 Vd NA 0.6057 L/kg 1compartment NA NA Human Human +DTXSID5049239 Vd NA 0.6217 L/kg 1compartment NA NA Human Human DTXSID5049239 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5049239 TK.Half.Life NA 4.63 hours 1compartment NA NA Human Human -DTXSID5049239 Css NA 0.9964 mg/L 3compartmentss NA 50% Human Human -DTXSID5049239 Css NA 5.933 mg/L 3compartmentss NA 95% Human Human -DTXSID5049239 Css NA 0.7897 mg/L PBTK NA 50% Human Human -DTXSID5049239 Css NA 3.798 mg/L PBTK NA 95% Human Human +DTXSID5049239 TK.Half.Life NA 4.754 hours 1compartment NA NA Human Human +DTXSID5049239 Css NA 0.8411 mg/L 3compartmentss NA 50% Human Human +DTXSID5049239 Css NA 5.006 mg/L 3compartmentss NA 95% Human Human +DTXSID5049239 Css NA 0.6738 mg/L PBTK NA 50% Human Human +DTXSID5049239 Css NA 3.19 mg/L PBTK NA 95% Human Human DTXSID5049239 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5049239 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049239 Vd NA 0.6562 L/kg 1compartment NA NA Rat Human +DTXSID5049239 Vd NA 0.6689 L/kg 1compartment NA NA Rat Human DTXSID5049239 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049239 TK.Half.Life NA 1.71 hours 1compartment NA NA Rat Human -DTXSID5049239 Css NA 0.2553 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049239 Css NA 1.448 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049239 Css NA 0.1961 mg/L PBTK NA 50% Rat Human -DTXSID5049239 Css NA 0.8574 mg/L PBTK NA 95% Rat Human +DTXSID5049239 TK.Half.Life NA 1.743 hours 1compartment NA NA Rat Human +DTXSID5049239 Css NA 0.01579 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049239 Css NA 0.1171 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049239 Css NA 0.01204 mg/L PBTK NA 50% Rat Human +DTXSID5049239 Css NA 0.07397 mg/L PBTK NA 95% Rat Human DTXSID5049287 Clint NA 0.3103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID5049287 Fup NA 0.1789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049287 Vd NA 1.255 L/kg 1compartment NA NA Human Human -DTXSID5049287 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5049287 TK.Half.Life NA 35.31 hours 1compartment NA NA Human Human -DTXSID5049287 Css NA 3.258 mg/L 3compartmentss NA 50% Human Human -DTXSID5049287 Css NA 11.81 mg/L 3compartmentss NA 95% Human Human -DTXSID5049287 Css NA 2.29 mg/L PBTK NA 50% Human Human -DTXSID5049287 Css NA 7.494 mg/L PBTK NA 95% Human Human +DTXSID5049287 Vd NA 1.118 L/kg 1compartment NA NA Human Human +DTXSID5049287 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5049287 TK.Half.Life NA 30.18 hours 1compartment NA NA Human Human +DTXSID5049287 Css NA 2.655 mg/L 3compartmentss NA 50% Human Human +DTXSID5049287 Css NA 10.16 mg/L 3compartmentss NA 95% Human Human +DTXSID5049287 Css NA 1.856 mg/L PBTK NA 50% Human Human +DTXSID5049287 Css NA 6.475 mg/L PBTK NA 95% Human Human DTXSID5049287 Clint NA 0.3103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID5049287 Fup NA 0.1789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049287 Vd NA 1.001 L/kg 1compartment NA NA Rat Human +DTXSID5049287 Vd NA 0.9029 L/kg 1compartment NA NA Rat Human DTXSID5049287 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5049287 TK.Half.Life NA 10.19 hours 1compartment NA NA Rat Human -DTXSID5049287 Css NA 1.115 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049287 Css NA 3.365 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049287 Css NA 0.746 mg/L PBTK NA 50% Rat Human -DTXSID5049287 Css NA 1.982 mg/L PBTK NA 95% Rat Human -DTXSID5049316 Clint NA 1.792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049316 Fup NA 0.3354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049316 Vd NA 1.48 L/kg 1compartment NA NA Human Human +DTXSID5049287 TK.Half.Life NA 9.102 hours 1compartment NA NA Rat Human +DTXSID5049287 Css NA 0.05969 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049287 Css NA 0.3274 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049287 Css NA 0.04006 mg/L PBTK NA 50% Rat Human +DTXSID5049287 Css NA 0.2061 mg/L PBTK NA 95% Rat Human +DTXSID5049316 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049316 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049316 Vd NA 0.8652 L/kg 1compartment NA NA Human Human DTXSID5049316 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5049316 TK.Half.Life NA 9.2 hours 1compartment NA NA Human Human -DTXSID5049316 Css NA 0.6464 mg/L 3compartmentss NA 50% Human Human -DTXSID5049316 Css NA 3.071 mg/L 3compartmentss NA 95% Human Human -DTXSID5049316 Css NA 0.5028 mg/L PBTK NA 50% Human Human -DTXSID5049316 Css NA 2.083 mg/L PBTK NA 95% Human Human -DTXSID5049316 Clint NA 1.792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049316 Fup NA 0.3354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049316 Vd NA 1.209 L/kg 1compartment NA NA Rat Human +DTXSID5049316 TK.Half.Life NA 4.82 hours 1compartment NA NA Human Human +DTXSID5049316 Css NA 0.7375 mg/L 3compartmentss NA 50% Human Human +DTXSID5049316 Css NA 4.986 mg/L 3compartmentss NA 95% Human Human +DTXSID5049316 Css NA 0.482 mg/L PBTK NA 50% Human Human +DTXSID5049316 Css NA 3.02 mg/L PBTK NA 95% Human Human +DTXSID5049316 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049316 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049316 Vd NA 0.7002 L/kg 1compartment NA NA Rat Human DTXSID5049316 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049316 TK.Half.Life NA 3.448 hours 1compartment NA NA Rat Human -DTXSID5049316 Css NA 0.2852 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049316 Css NA 1.019 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049316 Css NA 0.2134 mg/L PBTK NA 50% Rat Human -DTXSID5049316 Css NA 0.6373 mg/L PBTK NA 95% Rat Human -DTXSID5049318 Clint NA 0.08242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049318 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049318 Vd NA 0.5464 L/kg 1compartment NA NA Human Human +DTXSID5049316 TK.Half.Life NA 2.237 hours 1compartment NA NA Rat Human +DTXSID5049316 Css NA 0.08919 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049316 Css NA 0.4609 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049316 Css NA 0.05705 mg/L PBTK NA 50% Rat Human +DTXSID5049316 Css NA 0.2723 mg/L PBTK NA 95% Rat Human +DTXSID5049318 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049318 Fup 0.637 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049318 Vd NA 0.5126 L/kg 1compartment NA NA Human Human DTXSID5049318 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5049318 TK.Half.Life NA 3.115 hours 1compartment NA NA Human Human -DTXSID5049318 Css NA 0.7884 mg/L 3compartmentss NA 50% Human Human -DTXSID5049318 Css NA 4.913 mg/L 3compartmentss NA 95% Human Human -DTXSID5049318 Css NA 0.6014 mg/L PBTK NA 50% Human Human -DTXSID5049318 Css NA 3.129 mg/L PBTK NA 95% Human Human -DTXSID5049318 Clint NA 0.08242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049318 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049318 Vd NA 0.5692 L/kg 1compartment NA NA Rat Human +DTXSID5049318 TK.Half.Life NA 5.212 hours 1compartment NA NA Human Human +DTXSID5049318 Css NA 1.22 mg/L 3compartmentss NA 50% Human Human +DTXSID5049318 Css NA 7.513 mg/L 3compartmentss NA 95% Human Human +DTXSID5049318 Css NA 0.909 mg/L PBTK NA 50% Human Human +DTXSID5049318 Css NA 4.666 mg/L PBTK NA 95% Human Human +DTXSID5049318 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049318 Fup 0.637 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049318 Vd NA 0.5255 L/kg 1compartment NA NA Rat Human DTXSID5049318 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049318 TK.Half.Life NA 1.177 hours 1compartment NA NA Rat Human -DTXSID5049318 Css NA 0.2179 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049318 Css NA 1.273 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049318 Css NA 0.1617 mg/L PBTK NA 50% Rat Human -DTXSID5049318 Css NA 0.7433 mg/L PBTK NA 95% Rat Human -DTXSID5049362 Clint NA 0.523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049362 Fup NA 0.6373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5049362 Vd NA 1.068 L/kg 1compartment NA NA Human Human +DTXSID5049318 TK.Half.Life NA 1.819 hours 1compartment NA NA Rat Human +DTXSID5049318 Css NA 0.07527 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049318 Css NA 0.4365 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049318 Css NA 0.0555 mg/L PBTK NA 50% Rat Human +DTXSID5049318 Css NA 0.2605 mg/L PBTK NA 95% Rat Human +DTXSID5049362 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049362 Fup 0.54 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049362 Vd NA 0.4939 L/kg 1compartment NA NA Human Human DTXSID5049362 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5049362 TK.Half.Life NA 6.172 hours 1compartment NA NA Human Human -DTXSID5049362 Css NA 0.5941 mg/L 3compartmentss NA 50% Human Human -DTXSID5049362 Css NA 4.203 mg/L 3compartmentss NA 95% Human Human -DTXSID5049362 Css NA 0.5128 mg/L PBTK NA 50% Human Human -DTXSID5049362 Css NA 2.698 mg/L PBTK NA 95% Human Human -DTXSID5049362 Clint NA 0.523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049362 Fup NA 0.6373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5049362 Vd NA 0.9992 L/kg 1compartment NA NA Rat Human +DTXSID5049362 TK.Half.Life NA 5.919 hours 1compartment NA NA Human Human +DTXSID5049362 Css NA 1.366 mg/L 3compartmentss NA 50% Human Human +DTXSID5049362 Css NA 8.121 mg/L 3compartmentss NA 95% Human Human +DTXSID5049362 Css NA 1.021 mg/L PBTK NA 50% Human Human +DTXSID5049362 Css NA 5.036 mg/L PBTK NA 95% Human Human +DTXSID5049362 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049362 Fup 0.54 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049362 Vd NA 0.5277 L/kg 1compartment NA NA Rat Human DTXSID5049362 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5049362 TK.Half.Life NA 2.473 hours 1compartment NA NA Rat Human -DTXSID5049362 Css NA 0.2048 mg/L 3compartmentss NA 50% Rat Human -DTXSID5049362 Css NA 1.412 mg/L 3compartmentss NA 95% Rat Human -DTXSID5049362 Css NA 0.1706 mg/L PBTK NA 50% Rat Human -DTXSID5049362 Css NA 0.8441 mg/L PBTK NA 95% Rat Human -DTXSID5050426 Clint NA 220.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5050426 Fup NA 0.2623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5050426 Vd NA 0.5126 L/kg 1compartment NA NA Human Human +DTXSID5049362 TK.Half.Life NA 2.154 hours 1compartment NA NA Rat Human +DTXSID5049362 Css NA 0.08631 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049362 Css NA 0.4446 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049362 Css NA 0.06344 mg/L PBTK NA 50% Rat Human +DTXSID5049362 Css NA 0.2671 mg/L PBTK NA 95% Rat Human +DTXSID5049655 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049655 Fup 0.776 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5049655 Vd NA 0.7044 L/kg 1compartment NA NA Human Human +DTXSID5049655 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5049655 TK.Half.Life NA 5.879 hours 1compartment NA NA Human Human +DTXSID5049655 Css NA 0.9935 mg/L 3compartmentss NA 50% Human Human +DTXSID5049655 Css NA 6.338 mg/L 3compartmentss NA 95% Human Human +DTXSID5049655 Css NA 0.8086 mg/L PBTK NA 50% Human Human +DTXSID5049655 Css NA 4.073 mg/L PBTK NA 95% Human Human +DTXSID5049655 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049655 Fup 0.776 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5049655 Vd NA 0.7309 L/kg 1compartment NA NA Rat Human +DTXSID5049655 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5049655 TK.Half.Life NA 2.077 hours 1compartment NA NA Rat Human +DTXSID5049655 Css NA 0.05835 mg/L 3compartmentss NA 50% Rat Human +DTXSID5049655 Css NA 0.3624 mg/L 3compartmentss NA 95% Rat Human +DTXSID5049655 Css NA 0.04774 mg/L PBTK NA 50% Rat Human +DTXSID5049655 Css NA 0.2229 mg/L PBTK NA 95% Rat Human +DTXSID5050426 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5050426 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5050426 Vd NA 0.4087 L/kg 1compartment NA NA Human Human DTXSID5050426 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5050426 TK.Half.Life NA 0.4409 hours 1compartment NA NA Human Human -DTXSID5050426 Css NA 0.008456 mg/L 3compartmentss NA 50% Human Human -DTXSID5050426 Css NA 0.06787 mg/L 3compartmentss NA 95% Human Human -DTXSID5050426 Css NA 0.00585 mg/L PBTK NA 50% Human Human -DTXSID5050426 Css NA 0.04412 mg/L PBTK NA 95% Human Human -DTXSID5050426 Clint NA 220.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5050426 Fup NA 0.2623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5050426 Vd NA 0.4979 L/kg 1compartment NA NA Rat Human +DTXSID5050426 TK.Half.Life NA 5.497 hours 1compartment NA NA Human Human +DTXSID5050426 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human +DTXSID5050426 Css NA 6.55 mg/L 3compartmentss NA 95% Human Human +DTXSID5050426 Css NA 0.975 mg/L PBTK NA 50% Human Human +DTXSID5050426 Css NA 4.038 mg/L PBTK NA 95% Human Human +DTXSID5050426 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5050426 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5050426 Vd NA 0.4162 L/kg 1compartment NA NA Rat Human DTXSID5050426 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5050426 TK.Half.Life NA 0.194 hours 1compartment NA NA Rat Human -DTXSID5050426 Css NA 0.004792 mg/L 3compartmentss NA 50% Rat Human -DTXSID5050426 Css NA 0.0295 mg/L 3compartmentss NA 95% Rat Human -DTXSID5050426 Css NA 0.003159 mg/L PBTK NA 50% Rat Human -DTXSID5050426 Css NA 0.01839 mg/L PBTK NA 95% Rat Human -DTXSID5051440 Clint NA 23.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5051440 Fup NA 0.7433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5051440 Vd NA 4.141 L/kg 1compartment NA NA Human Human -DTXSID5051440 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5051440 TK.Half.Life NA 2.235 hours 1compartment NA NA Human Human -DTXSID5051440 Css NA 0.0166 mg/L 3compartmentss NA 50% Human Human -DTXSID5051440 Css NA 0.1959 mg/L 3compartmentss NA 95% Human Human -DTXSID5051440 Css NA 0.02257 mg/L PBTK NA 50% Human Human -DTXSID5051440 Css NA 0.1922 mg/L PBTK NA 95% Human Human -DTXSID5051440 Clint NA 23.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5051440 Fup NA 0.7433 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5051440 Vd NA 4.225 L/kg 1compartment NA NA Rat Human -DTXSID5051440 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5051440 TK.Half.Life NA 1.179 hours 1compartment NA NA Rat Human -DTXSID5051440 Css NA 0.007995 mg/L 3compartmentss NA 50% Rat Human -DTXSID5051440 Css NA 0.09043 mg/L 3compartmentss NA 95% Rat Human -DTXSID5051440 Css NA 0.01117 mg/L PBTK NA 50% Rat Human -DTXSID5051440 Css NA 0.07899 mg/L PBTK NA 95% Rat Human -DTXSID5051444 Clint NA 33.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5051444 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5051444 Vd NA 1.798 L/kg 1compartment NA NA Human Human -DTXSID5051444 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5051444 TK.Half.Life NA 12.56 hours 1compartment NA NA Human Human -DTXSID5051444 Css NA 1.043 mg/L 3compartmentss NA 50% Human Human -DTXSID5051444 Css NA 9 mg/L 3compartmentss NA 95% Human Human -DTXSID5051444 Css NA 0.6626 mg/L PBTK NA 50% Human Human -DTXSID5051444 Css NA 5.506 mg/L PBTK NA 95% Human Human -DTXSID5051444 Clint NA 33.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5051444 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5051444 Vd NA 1.334 L/kg 1compartment NA NA Rat Human -DTXSID5051444 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5051444 TK.Half.Life NA 4.381 hours 1compartment NA NA Rat Human -DTXSID5051444 Css NA 0.5826 mg/L 3compartmentss NA 50% Rat Human -DTXSID5051444 Css NA 4.324 mg/L 3compartmentss NA 95% Rat Human -DTXSID5051444 Css NA 0.3484 mg/L PBTK NA 50% Rat Human -DTXSID5051444 Css NA 2.444 mg/L PBTK NA 95% Rat Human -DTXSID5051446 Clint NA 1.559 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5051446 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5051446 Vd NA 1.195 L/kg 1compartment NA NA Human Human +DTXSID5050426 TK.Half.Life NA 1.908 hours 1compartment NA NA Rat Human +DTXSID5050426 Css NA 0.0342 mg/L 3compartmentss NA 50% Rat Human +DTXSID5050426 Css NA 0.2173 mg/L 3compartmentss NA 95% Rat Human +DTXSID5050426 Css NA 0.0237 mg/L PBTK NA 50% Rat Human +DTXSID5050426 Css NA 0.1327 mg/L PBTK NA 95% Rat Human +DTXSID5051440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051440 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051440 Vd NA 3.35 L/kg 1compartment NA NA Human Human +DTXSID5051440 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5051440 TK.Half.Life NA 35.1 hours 1compartment NA NA Human Human +DTXSID5051440 Css NA 0.7575 mg/L 3compartmentss NA 50% Human Human +DTXSID5051440 Css NA 6.745 mg/L 3compartmentss NA 95% Human Human +DTXSID5051440 Css NA 0.9352 mg/L PBTK NA 50% Human Human +DTXSID5051440 Css NA 4.983 mg/L PBTK NA 95% Human Human +DTXSID5051440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051440 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051440 Vd NA 3.404 L/kg 1compartment NA NA Rat Human +DTXSID5051440 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5051440 TK.Half.Life NA 12.13 hours 1compartment NA NA Rat Human +DTXSID5051440 Css NA 0.04444 mg/L 3compartmentss NA 50% Rat Human +DTXSID5051440 Css NA 0.3876 mg/L 3compartmentss NA 95% Rat Human +DTXSID5051440 Css NA 0.05687 mg/L PBTK NA 50% Rat Human +DTXSID5051440 Css NA 0.2749 mg/L PBTK NA 95% Rat Human +DTXSID5051444 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051444 Fup 0.007 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051444 Vd NA 1.293 L/kg 1compartment NA NA Human Human +DTXSID5051444 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID5051444 TK.Half.Life NA 24.76 hours 1compartment NA NA Human Human +DTXSID5051444 Css NA 3.242 mg/L 3compartmentss NA 50% Human Human +DTXSID5051444 Css NA 30.45 mg/L 3compartmentss NA 95% Human Human +DTXSID5051444 Css NA 1.972 mg/L PBTK NA 50% Human Human +DTXSID5051444 Css NA 18.2 mg/L PBTK NA 95% Human Human +DTXSID5051444 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051444 Fup 0.007 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051444 Vd NA 0.9508 L/kg 1compartment NA NA Rat Human +DTXSID5051444 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5051444 TK.Half.Life NA 10.14 hours 1compartment NA NA Rat Human +DTXSID5051444 Css NA 0.4254 mg/L 3compartmentss NA 50% Rat Human +DTXSID5051444 Css NA 3.154 mg/L 3compartmentss NA 95% Rat Human +DTXSID5051444 Css NA 0.2516 mg/L PBTK NA 50% Rat Human +DTXSID5051444 Css NA 1.822 mg/L PBTK NA 95% Rat Human +DTXSID5051446 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051446 Fup 0.701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051446 Vd NA 0.9622 L/kg 1compartment NA NA Human Human DTXSID5051446 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5051446 TK.Half.Life NA 2.546 hours 1compartment NA NA Human Human -DTXSID5051446 Css NA 0.2156 mg/L 3compartmentss NA 50% Human Human -DTXSID5051446 Css NA 1.624 mg/L 3compartmentss NA 95% Human Human -DTXSID5051446 Css NA 0.1978 mg/L PBTK NA 50% Human Human -DTXSID5051446 Css NA 1.135 mg/L PBTK NA 95% Human Human -DTXSID5051446 Clint NA 1.559 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5051446 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5051446 Vd NA 1.155 L/kg 1compartment NA NA Rat Human +DTXSID5051446 TK.Half.Life NA 9.107 hours 1compartment NA NA Human Human +DTXSID5051446 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human +DTXSID5051446 Css NA 6.971 mg/L 3compartmentss NA 95% Human Human +DTXSID5051446 Css NA 0.876 mg/L PBTK NA 50% Human Human +DTXSID5051446 Css NA 4.44 mg/L PBTK NA 95% Human Human +DTXSID5051446 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051446 Fup 0.701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051446 Vd NA 0.9271 L/kg 1compartment NA NA Rat Human DTXSID5051446 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5051446 TK.Half.Life NA 1.216 hours 1compartment NA NA Rat Human -DTXSID5051446 Css NA 0.08666 mg/L 3compartmentss NA 50% Rat Human -DTXSID5051446 Css NA 0.5818 mg/L 3compartmentss NA 95% Rat Human -DTXSID5051446 Css NA 0.07934 mg/L PBTK NA 50% Rat Human -DTXSID5051446 Css NA 0.3682 mg/L PBTK NA 95% Rat Human +DTXSID5051446 TK.Half.Life NA 2.935 hours 1compartment NA NA Rat Human +DTXSID5051446 Css NA 0.06124 mg/L 3compartmentss NA 50% Rat Human +DTXSID5051446 Css NA 0.3859 mg/L 3compartmentss NA 95% Rat Human +DTXSID5051446 Css NA 0.05248 mg/L PBTK NA 50% Rat Human +DTXSID5051446 Css NA 0.2409 mg/L PBTK NA 95% Rat Human +DTXSID5051602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051602 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051602 Vd NA 0.7388 L/kg 1compartment NA NA Human Human +DTXSID5051602 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5051602 TK.Half.Life NA 2.165 hours 1compartment NA NA Human Human +DTXSID5051602 Css NA 0.2676 mg/L 3compartmentss NA 50% Human Human +DTXSID5051602 Css NA 1.682 mg/L 3compartmentss NA 95% Human Human +DTXSID5051602 Css NA 0.1901 mg/L PBTK NA 50% Human Human +DTXSID5051602 Css NA 1.08 mg/L PBTK NA 95% Human Human +DTXSID5051602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051602 Fup 0.253 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051602 Vd NA 0.6589 L/kg 1compartment NA NA Rat Human +DTXSID5051602 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5051602 TK.Half.Life NA 1.097 hours 1compartment NA NA Rat Human +DTXSID5051602 Css NA 0.03224 mg/L 3compartmentss NA 50% Rat Human +DTXSID5051602 Css NA 0.1408 mg/L 3compartmentss NA 95% Rat Human +DTXSID5051602 Css NA 0.02262 mg/L PBTK NA 50% Rat Human +DTXSID5051602 Css NA 0.08879 mg/L PBTK NA 95% Rat Human DTXSID5051650 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID5051650 Fup 2.48e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID5051650 Vd NA 4.344 L/kg 1compartment NA NA Human Human -DTXSID5051650 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID5051650 TK.Half.Life NA 281200 hours 1compartment NA NA Human Human -DTXSID5051650 Css NA 5907 mg/L 3compartmentss NA 50% Human Human -DTXSID5051650 Css NA 11980 mg/L 3compartmentss NA 95% Human Human -DTXSID5051650 Css NA 4618 mg/L PBTK NA 50% Human Human -DTXSID5051650 Css NA 9180 mg/L PBTK NA 95% Human Human +DTXSID5051650 Vd NA 1.197 L/kg 1compartment NA NA Human Human +DTXSID5051650 Days.Css NA 11150 Days PBTK NA NA Human Human +DTXSID5051650 TK.Half.Life NA 77470 hours 1compartment NA NA Human Human +DTXSID5051650 Css NA 5584 mg/L 3compartmentss NA 50% Human Human +DTXSID5051650 Css NA 13570 mg/L 3compartmentss NA 95% Human Human +DTXSID5051650 Css NA 3464 mg/L PBTK NA 50% Human Human +DTXSID5051650 Css NA 8112 mg/L PBTK NA 95% Human Human DTXSID5051650 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID5051650 Fup 2.48e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID5051650 Vd NA 3.297 L/kg 1compartment NA NA Rat Human -DTXSID5051650 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID5051650 TK.Half.Life NA 72690 hours 1compartment NA NA Rat Human -DTXSID5051650 Css NA 1778 mg/L 3compartmentss NA 50% Rat Human -DTXSID5051650 Css NA 1778 mg/L 3compartmentss NA 95% Rat Human -DTXSID5051650 Css NA 1325 mg/L PBTK NA 50% Rat Human -DTXSID5051650 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID5051999 Clint NA 5.565 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5051999 Fup NA 0.0295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5051999 Vd NA 1.444 L/kg 1compartment NA NA Human Human +DTXSID5051650 Vd NA 0.872 L/kg 1compartment NA NA Rat Human +DTXSID5051650 Days.Css NA 5309 Days PBTK NA NA Rat Human +DTXSID5051650 TK.Half.Life NA 19220 hours 1compartment NA NA Rat Human +DTXSID5051650 Css NA 471.8 mg/L 3compartmentss NA 50% Rat Human +DTXSID5051650 Css NA 528.9 mg/L 3compartmentss NA 95% Rat Human +DTXSID5051650 Css NA 279 mg/L PBTK NA 50% Rat Human +DTXSID5051650 Css NA 311.2 mg/L PBTK NA 95% Rat Human +DTXSID5051735 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051735 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051735 Vd NA 2.096 L/kg 1compartment NA NA Human Human +DTXSID5051735 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5051735 TK.Half.Life NA 4.384 hours 1compartment NA NA Human Human +DTXSID5051735 Css NA 0.1574 mg/L 3compartmentss NA 50% Human Human +DTXSID5051735 Css NA 1.049 mg/L 3compartmentss NA 95% Human Human +DTXSID5051735 Css NA 0.1149 mg/L PBTK NA 50% Human Human +DTXSID5051735 Css NA 0.7227 mg/L PBTK NA 95% Human Human +DTXSID5051735 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051735 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051735 Vd NA 1.614 L/kg 1compartment NA NA Rat Human +DTXSID5051735 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5051735 TK.Half.Life NA 1.452 hours 1compartment NA NA Rat Human +DTXSID5051735 Css NA 0.01994 mg/L 3compartmentss NA 50% Rat Human +DTXSID5051735 Css NA 0.1009 mg/L 3compartmentss NA 95% Rat Human +DTXSID5051735 Css NA 0.01444 mg/L PBTK NA 50% Rat Human +DTXSID5051735 Css NA 0.06867 mg/L PBTK NA 95% Rat Human +DTXSID5051999 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051999 Fup 0.0114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5051999 Vd NA 2.405 L/kg 1compartment NA NA Human Human DTXSID5051999 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5051999 TK.Half.Life NA 33.12 hours 1compartment NA NA Human Human -DTXSID5051999 Css NA 3.844 mg/L 3compartmentss NA 50% Human Human -DTXSID5051999 Css NA 28.41 mg/L 3compartmentss NA 95% Human Human -DTXSID5051999 Css NA 2.418 mg/L PBTK NA 50% Human Human -DTXSID5051999 Css NA 17.09 mg/L PBTK NA 95% Human Human -DTXSID5051999 Clint NA 5.565 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5051999 Fup NA 0.0295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5051999 Vd NA 1.076 L/kg 1compartment NA NA Rat Human +DTXSID5051999 TK.Half.Life NA 38.62 hours 1compartment NA NA Human Human +DTXSID5051999 Css NA 2.328 mg/L 3compartmentss NA 50% Human Human +DTXSID5051999 Css NA 17.46 mg/L 3compartmentss NA 95% Human Human +DTXSID5051999 Css NA 1.519 mg/L PBTK NA 50% Human Human +DTXSID5051999 Css NA 11.07 mg/L PBTK NA 95% Human Human +DTXSID5051999 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051999 Fup 0.0114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5051999 Vd NA 1.789 L/kg 1compartment NA NA Rat Human DTXSID5051999 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5051999 TK.Half.Life NA 12.53 hours 1compartment NA NA Rat Human -DTXSID5051999 Css NA 2.011 mg/L 3compartmentss NA 50% Rat Human -DTXSID5051999 Css NA 12.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID5051999 Css NA 1.189 mg/L PBTK NA 50% Rat Human -DTXSID5051999 Css NA 6.792 mg/L PBTK NA 95% Rat Human -DTXSID5052042 Clint NA 5.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052042 Fup NA 0.563 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052042 Vd NA 1.391 L/kg 1compartment NA NA Human Human +DTXSID5051999 TK.Half.Life NA 10.05 hours 1compartment NA NA Rat Human +DTXSID5051999 Css NA 0.298 mg/L 3compartmentss NA 50% Rat Human +DTXSID5051999 Css NA 1.964 mg/L 3compartmentss NA 95% Rat Human +DTXSID5051999 Css NA 0.1915 mg/L PBTK NA 50% Rat Human +DTXSID5051999 Css NA 1.222 mg/L PBTK NA 95% Rat Human +DTXSID5052042 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052042 Fup 0.226 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052042 Vd NA 0.8259 L/kg 1compartment NA NA Human Human DTXSID5052042 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5052042 TK.Half.Life NA 2.609 hours 1compartment NA NA Human Human -DTXSID5052042 Css NA 0.153 mg/L 3compartmentss NA 50% Human Human -DTXSID5052042 Css NA 1.289 mg/L 3compartmentss NA 95% Human Human -DTXSID5052042 Css NA 0.129 mg/L PBTK NA 50% Human Human -DTXSID5052042 Css NA 0.8784 mg/L PBTK NA 95% Human Human -DTXSID5052042 Clint NA 5.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052042 Fup NA 0.563 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052042 Vd NA 1.207 L/kg 1compartment NA NA Rat Human +DTXSID5052042 TK.Half.Life NA 1.269 hours 1compartment NA NA Human Human +DTXSID5052042 Css NA 0.0939 mg/L 3compartmentss NA 50% Human Human +DTXSID5052042 Css NA 0.7045 mg/L 3compartmentss NA 95% Human Human +DTXSID5052042 Css NA 0.06568 mg/L PBTK NA 50% Human Human +DTXSID5052042 Css NA 0.4647 mg/L PBTK NA 95% Human Human +DTXSID5052042 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052042 Fup 0.226 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052042 Vd NA 0.7119 L/kg 1compartment NA NA Rat Human DTXSID5052042 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5052042 TK.Half.Life NA 1.155 hours 1compartment NA NA Rat Human -DTXSID5052042 Css NA 0.07329 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052042 Css NA 0.5399 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052042 Css NA 0.06087 mg/L PBTK NA 50% Rat Human -DTXSID5052042 Css NA 0.3377 mg/L PBTK NA 95% Rat Human -DTXSID5052254 Clint NA 1.863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052254 Fup NA 0.6516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052254 Vd NA 1.835 L/kg 1compartment NA NA Human Human +DTXSID5052042 TK.Half.Life NA 0.5869 hours 1compartment NA NA Rat Human +DTXSID5052042 Css NA 0.01193 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052042 Css NA 0.06296 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052042 Css NA 0.008297 mg/L PBTK NA 50% Rat Human +DTXSID5052042 Css NA 0.04154 mg/L PBTK NA 95% Rat Human +DTXSID5052125 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052125 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052125 Vd NA 1.409 L/kg 1compartment NA NA Human Human +DTXSID5052125 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5052125 TK.Half.Life NA 3.266 hours 1compartment NA NA Human Human +DTXSID5052125 Css NA 0.221 mg/L 3compartmentss NA 50% Human Human +DTXSID5052125 Css NA 1.758 mg/L 3compartmentss NA 95% Human Human +DTXSID5052125 Css NA 0.1494 mg/L PBTK NA 50% Human Human +DTXSID5052125 Css NA 1.11 mg/L PBTK NA 95% Human Human +DTXSID5052125 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052125 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052125 Vd NA 1.094 L/kg 1compartment NA NA Rat Human +DTXSID5052125 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5052125 TK.Half.Life NA 1.299 hours 1compartment NA NA Rat Human +DTXSID5052125 Css NA 0.0282 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052125 Css NA 0.1725 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052125 Css NA 0.01872 mg/L PBTK NA 50% Rat Human +DTXSID5052125 Css NA 0.1079 mg/L PBTK NA 95% Rat Human +DTXSID5052254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052254 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052254 Vd NA 1.572 L/kg 1compartment NA NA Human Human DTXSID5052254 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5052254 TK.Half.Life NA 6.086 hours 1compartment NA NA Human Human -DTXSID5052254 Css NA 0.3028 mg/L 3compartmentss NA 50% Human Human -DTXSID5052254 Css NA 2.211 mg/L 3compartmentss NA 95% Human Human -DTXSID5052254 Css NA 0.2758 mg/L PBTK NA 50% Human Human -DTXSID5052254 Css NA 1.528 mg/L PBTK NA 95% Human Human -DTXSID5052254 Clint NA 1.863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052254 Fup NA 0.6516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052254 Vd NA 1.588 L/kg 1compartment NA NA Rat Human +DTXSID5052254 TK.Half.Life NA 1.595 hours 1compartment NA NA Human Human +DTXSID5052254 Css NA 0.03342 mg/L 3compartmentss NA 50% Human Human +DTXSID5052254 Css NA 0.3195 mg/L 3compartmentss NA 95% Human Human +DTXSID5052254 Css NA 0.02801 mg/L PBTK NA 50% Human Human +DTXSID5052254 Css NA 0.2327 mg/L PBTK NA 95% Human Human +DTXSID5052254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052254 Fup 0.485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052254 Vd NA 1.355 L/kg 1compartment NA NA Rat Human DTXSID5052254 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5052254 TK.Half.Life NA 2.371 hours 1compartment NA NA Rat Human -DTXSID5052254 Css NA 0.1283 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052254 Css NA 0.8675 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052254 Css NA 0.1147 mg/L PBTK NA 50% Rat Human -DTXSID5052254 Css NA 0.5438 mg/L PBTK NA 95% Rat Human -DTXSID5052460 Clint NA 4.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052460 Fup NA 0.0591 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052460 Vd NA 1.881 L/kg 1compartment NA NA Human Human -DTXSID5052460 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID5052460 TK.Half.Life NA 32.59 hours 1compartment NA NA Human Human -DTXSID5052460 Css NA 2.586 mg/L 3compartmentss NA 50% Human Human -DTXSID5052460 Css NA 14.91 mg/L 3compartmentss NA 95% Human Human -DTXSID5052460 Css NA 1.696 mg/L PBTK NA 50% Human Human -DTXSID5052460 Css NA 9.213 mg/L PBTK NA 95% Human Human -DTXSID5052460 Clint NA 4.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052460 Fup NA 0.0591 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052460 Vd NA 1.413 L/kg 1compartment NA NA Rat Human -DTXSID5052460 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5052460 TK.Half.Life NA 10.54 hours 1compartment NA NA Rat Human -DTXSID5052460 Css NA 1.348 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052460 Css NA 5.824 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052460 Css NA 0.8386 mg/L PBTK NA 50% Rat Human -DTXSID5052460 Css NA 3.395 mg/L PBTK NA 95% Rat Human -DTXSID5052591 Clint NA 53.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052591 Fup NA 0.399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052591 Vd NA 0.796 L/kg 1compartment NA NA Human Human +DTXSID5052254 TK.Half.Life NA 0.6665 hours 1compartment NA NA Rat Human +DTXSID5052254 Css NA 0.001208 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052254 Css NA 0.01221 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052254 Css NA 0.001001 mg/L PBTK NA 50% Rat Human +DTXSID5052254 Css NA 0.008779 mg/L PBTK NA 95% Rat Human +DTXSID5052460 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052460 Fup 0.0499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052460 Vd NA 1.765 L/kg 1compartment NA NA Human Human +DTXSID5052460 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5052460 TK.Half.Life NA 8.872 hours 1compartment NA NA Human Human +DTXSID5052460 Css NA 0.6647 mg/L 3compartmentss NA 50% Human Human +DTXSID5052460 Css NA 5.092 mg/L 3compartmentss NA 95% Human Human +DTXSID5052460 Css NA 0.4302 mg/L PBTK NA 50% Human Human +DTXSID5052460 Css NA 3.173 mg/L PBTK NA 95% Human Human +DTXSID5052460 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052460 Fup 0.0499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052460 Vd NA 1.324 L/kg 1compartment NA NA Rat Human +DTXSID5052460 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5052460 TK.Half.Life NA 3.155 hours 1compartment NA NA Rat Human +DTXSID5052460 Css NA 0.0858 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052460 Css NA 0.509 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052460 Css NA 0.05425 mg/L PBTK NA 50% Rat Human +DTXSID5052460 Css NA 0.3083 mg/L PBTK NA 95% Rat Human +DTXSID5052468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052468 Fup 0.0435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052468 Vd NA 0.8185 L/kg 1compartment NA NA Human Human +DTXSID5052468 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5052468 TK.Half.Life NA 3.907 hours 1compartment NA NA Human Human +DTXSID5052468 Css NA 0.665 mg/L 3compartmentss NA 50% Human Human +DTXSID5052468 Css NA 6.317 mg/L 3compartmentss NA 95% Human Human +DTXSID5052468 Css NA 0.4122 mg/L PBTK NA 50% Human Human +DTXSID5052468 Css NA 3.77 mg/L PBTK NA 95% Human Human +DTXSID5052468 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052468 Fup 0.0435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052468 Vd NA 0.6303 L/kg 1compartment NA NA Rat Human +DTXSID5052468 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5052468 TK.Half.Life NA 1.791 hours 1compartment NA NA Rat Human +DTXSID5052468 Css NA 0.08784 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052468 Css NA 0.6272 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052468 Css NA 0.05261 mg/L PBTK NA 50% Rat Human +DTXSID5052468 Css NA 0.3609 mg/L PBTK NA 95% Rat Human +DTXSID5052591 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052591 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052591 Vd NA 1.315 L/kg 1compartment NA NA Human Human DTXSID5052591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5052591 TK.Half.Life NA 0.6968 hours 1compartment NA NA Human Human -DTXSID5052591 Css NA 0.02144 mg/L 3compartmentss NA 50% Human Human -DTXSID5052591 Css NA 0.1788 mg/L 3compartmentss NA 95% Human Human -DTXSID5052591 Css NA 0.01643 mg/L PBTK NA 50% Human Human -DTXSID5052591 Css NA 0.1235 mg/L PBTK NA 95% Human Human -DTXSID5052591 Clint NA 53.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052591 Fup NA 0.399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052591 Vd NA 0.7406 L/kg 1compartment NA NA Rat Human +DTXSID5052591 TK.Half.Life NA 1.539 hours 1compartment NA NA Human Human +DTXSID5052591 Css NA 0.05512 mg/L 3compartmentss NA 50% Human Human +DTXSID5052591 Css NA 0.423 mg/L 3compartmentss NA 95% Human Human +DTXSID5052591 Css NA 0.04322 mg/L PBTK NA 50% Human Human +DTXSID5052591 Css NA 0.2981 mg/L PBTK NA 95% Human Human +DTXSID5052591 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052591 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052591 Vd NA 1.105 L/kg 1compartment NA NA Rat Human DTXSID5052591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5052591 TK.Half.Life NA 0.3093 hours 1compartment NA NA Rat Human -DTXSID5052591 Css NA 0.0116 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052591 Css NA 0.07738 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052591 Css NA 0.008447 mg/L PBTK NA 50% Rat Human -DTXSID5052591 Css NA 0.05052 mg/L PBTK NA 95% Rat Human -DTXSID5052593 Clint NA 3.141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052593 Fup NA 0.3916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052593 Vd NA 1.771 L/kg 1compartment NA NA Human Human +DTXSID5052591 TK.Half.Life NA 0.6424 hours 1compartment NA NA Rat Human +DTXSID5052591 Css NA 0.006892 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052591 Css NA 0.03856 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052591 Css NA 0.005361 mg/L PBTK NA 50% Rat Human +DTXSID5052591 Css NA 0.02728 mg/L PBTK NA 95% Rat Human +DTXSID5052593 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052593 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052593 Vd NA 0.9529 L/kg 1compartment NA NA Human Human DTXSID5052593 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5052593 TK.Half.Life NA 7.104 hours 1compartment NA NA Human Human -DTXSID5052593 Css NA 0.3866 mg/L 3compartmentss NA 50% Human Human -DTXSID5052593 Css NA 2.004 mg/L 3compartmentss NA 95% Human Human -DTXSID5052593 Css NA 0.3075 mg/L PBTK NA 50% Human Human -DTXSID5052593 Css NA 1.397 mg/L PBTK NA 95% Human Human -DTXSID5052593 Clint NA 3.141 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052593 Fup NA 0.3916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052593 Vd NA 1.43 L/kg 1compartment NA NA Rat Human +DTXSID5052593 TK.Half.Life NA 2.379 hours 1compartment NA NA Human Human +DTXSID5052593 Css NA 0.2609 mg/L 3compartmentss NA 50% Human Human +DTXSID5052593 Css NA 2.105 mg/L 3compartmentss NA 95% Human Human +DTXSID5052593 Css NA 0.1697 mg/L PBTK NA 50% Human Human +DTXSID5052593 Css NA 1.306 mg/L PBTK NA 95% Human Human +DTXSID5052593 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052593 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052593 Vd NA 0.7567 L/kg 1compartment NA NA Rat Human DTXSID5052593 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5052593 TK.Half.Life NA 2.587 hours 1compartment NA NA Rat Human -DTXSID5052593 Css NA 0.1834 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052593 Css NA 0.7407 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052593 Css NA 0.141 mg/L PBTK NA 50% Rat Human -DTXSID5052593 Css NA 0.4874 mg/L PBTK NA 95% Rat Human -DTXSID5052595 Clint NA 9.046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052595 Fup NA 0.2559 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052595 Vd NA 1.703 L/kg 1compartment NA NA Human Human +DTXSID5052593 TK.Half.Life NA 1.054 hours 1compartment NA NA Rat Human +DTXSID5052593 Css NA 0.03406 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052593 Css NA 0.2057 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052593 Css NA 0.02154 mg/L PBTK NA 50% Rat Human +DTXSID5052593 Css NA 0.1232 mg/L PBTK NA 95% Rat Human +DTXSID5052595 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052595 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052595 Vd NA 1.203 L/kg 1compartment NA NA Human Human DTXSID5052595 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5052595 TK.Half.Life NA 4.609 hours 1compartment NA NA Human Human -DTXSID5052595 Css NA 0.2444 mg/L 3compartmentss NA 50% Human Human -DTXSID5052595 Css NA 1.442 mg/L 3compartmentss NA 95% Human Human -DTXSID5052595 Css NA 0.1822 mg/L PBTK NA 50% Human Human -DTXSID5052595 Css NA 1.006 mg/L PBTK NA 95% Human Human -DTXSID5052595 Clint NA 9.046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052595 Fup NA 0.2559 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052595 Vd NA 1.345 L/kg 1compartment NA NA Rat Human +DTXSID5052595 TK.Half.Life NA 2.843 hours 1compartment NA NA Human Human +DTXSID5052595 Css NA 0.2322 mg/L 3compartmentss NA 50% Human Human +DTXSID5052595 Css NA 1.8 mg/L 3compartmentss NA 95% Human Human +DTXSID5052595 Css NA 0.1546 mg/L PBTK NA 50% Human Human +DTXSID5052595 Css NA 1.139 mg/L PBTK NA 95% Human Human +DTXSID5052595 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052595 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052595 Vd NA 0.9412 L/kg 1compartment NA NA Rat Human DTXSID5052595 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5052595 TK.Half.Life NA 1.745 hours 1compartment NA NA Rat Human -DTXSID5052595 Css NA 0.1276 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052595 Css NA 0.5551 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052595 Css NA 0.09151 mg/L PBTK NA 50% Rat Human -DTXSID5052595 Css NA 0.3627 mg/L PBTK NA 95% Rat Human -DTXSID5052597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052597 Fup NA 0.8745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052597 Vd NA 0.5015 L/kg 1compartment NA NA Human Human +DTXSID5052595 TK.Half.Life NA 1.186 hours 1compartment NA NA Rat Human +DTXSID5052595 Css NA 0.03016 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052595 Css NA 0.1845 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052595 Css NA 0.01965 mg/L PBTK NA 50% Rat Human +DTXSID5052595 Css NA 0.1106 mg/L PBTK NA 95% Rat Human +DTXSID5052597 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052597 Fup 0.666 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052597 Vd NA 0.4343 L/kg 1compartment NA NA Human Human DTXSID5052597 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5052597 TK.Half.Life NA 3.711 hours 1compartment NA NA Human Human -DTXSID5052597 Css NA 1.036 mg/L 3compartmentss NA 50% Human Human -DTXSID5052597 Css NA 5.494 mg/L 3compartmentss NA 95% Human Human -DTXSID5052597 Css NA 0.7798 mg/L PBTK NA 50% Human Human -DTXSID5052597 Css NA 3.466 mg/L PBTK NA 95% Human Human -DTXSID5052597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052597 Fup NA 0.8745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052597 Vd NA 0.521 L/kg 1compartment NA NA Rat Human +DTXSID5052597 TK.Half.Life NA 4.219 hours 1compartment NA NA Human Human +DTXSID5052597 Css NA 1.215 mg/L 3compartmentss NA 50% Human Human +DTXSID5052597 Css NA 7.42 mg/L 3compartmentss NA 95% Human Human +DTXSID5052597 Css NA 0.8844 mg/L PBTK NA 50% Human Human +DTXSID5052597 Css NA 4.594 mg/L PBTK NA 95% Human Human +DTXSID5052597 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052597 Fup 0.666 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052597 Vd NA 0.4501 L/kg 1compartment NA NA Rat Human DTXSID5052597 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5052597 TK.Half.Life NA 1.314 hours 1compartment NA NA Rat Human -DTXSID5052597 Css NA 0.2671 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052597 Css NA 1.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052597 Css NA 0.1935 mg/L PBTK NA 50% Rat Human -DTXSID5052597 Css NA 0.8336 mg/L PBTK NA 95% Rat Human -DTXSID5052620 Clint NA 193.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052620 Fup NA 0.5419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052620 Vd NA 1.715 L/kg 1compartment NA NA Human Human +DTXSID5052597 TK.Half.Life NA 1.49 hours 1compartment NA NA Rat Human +DTXSID5052597 Css NA 0.07381 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052597 Css NA 0.4217 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052597 Css NA 0.05326 mg/L PBTK NA 50% Rat Human +DTXSID5052597 Css NA 0.2504 mg/L PBTK NA 95% Rat Human +DTXSID5052620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052620 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052620 Vd NA 1.208 L/kg 1compartment NA NA Human Human DTXSID5052620 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5052620 TK.Half.Life NA 1.143 hours 1compartment NA NA Human Human -DTXSID5052620 Css NA 0.005048 mg/L 3compartmentss NA 50% Human Human -DTXSID5052620 Css NA 0.05223 mg/L 3compartmentss NA 95% Human Human -DTXSID5052620 Css NA 0.004295 mg/L PBTK NA 50% Human Human -DTXSID5052620 Css NA 0.03717 mg/L PBTK NA 95% Human Human -DTXSID5052620 Clint NA 193.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052620 Fup NA 0.5419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052620 Vd NA 1.429 L/kg 1compartment NA NA Rat Human +DTXSID5052620 TK.Half.Life NA 1.699 hours 1compartment NA NA Human Human +DTXSID5052620 Css NA 0.07984 mg/L 3compartmentss NA 50% Human Human +DTXSID5052620 Css NA 0.5733 mg/L 3compartmentss NA 95% Human Human +DTXSID5052620 Css NA 0.05876 mg/L PBTK NA 50% Human Human +DTXSID5052620 Css NA 0.3889 mg/L PBTK NA 95% Human Human +DTXSID5052620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052620 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052620 Vd NA 0.9975 L/kg 1compartment NA NA Rat Human DTXSID5052620 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5052620 TK.Half.Life NA 0.4156 hours 1compartment NA NA Rat Human -DTXSID5052620 Css NA 0.002737 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052620 Css NA 0.02364 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052620 Css NA 0.002242 mg/L PBTK NA 50% Rat Human -DTXSID5052620 Css NA 0.01626 mg/L PBTK NA 95% Rat Human -DTXSID5052672 Clint NA 3.588 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052672 Fup NA 0.2615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052672 Vd NA 2.502 L/kg 1compartment NA NA Human Human -DTXSID5052672 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5052672 TK.Half.Life NA 21.93 hours 1compartment NA NA Human Human -DTXSID5052672 Css NA 0.9572 mg/L 3compartmentss NA 50% Human Human -DTXSID5052672 Css NA 4.558 mg/L 3compartmentss NA 95% Human Human -DTXSID5052672 Css NA 0.7117 mg/L PBTK NA 50% Human Human -DTXSID5052672 Css NA 3.158 mg/L PBTK NA 95% Human Human -DTXSID5052672 Clint NA 3.588 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052672 Fup NA 0.2615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052672 Vd NA 1.917 L/kg 1compartment NA NA Rat Human -DTXSID5052672 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5052672 TK.Half.Life NA 5.369 hours 1compartment NA NA Rat Human -DTXSID5052672 Css NA 0.4756 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052672 Css NA 1.577 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052672 Css NA 0.3418 mg/L PBTK NA 50% Rat Human -DTXSID5052672 Css NA 1.04 mg/L PBTK NA 95% Rat Human -DTXSID5052832 Clint NA 2.607 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052832 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052832 Vd NA 15.88 L/kg 1compartment NA NA Human Human -DTXSID5052832 Days.Css NA 1032 Days PBTK NA NA Human Human -DTXSID5052832 TK.Half.Life NA 3862 hours 1compartment NA NA Human Human -DTXSID5052832 Css NA 11.76 mg/L 3compartmentss NA 50% Human Human -DTXSID5052832 Css NA 68.58 mg/L 3compartmentss NA 95% Human Human -DTXSID5052832 Css NA 20.15 mg/L PBTK NA 50% Human Human -DTXSID5052832 Css NA 110.2 mg/L PBTK NA 95% Human Human -DTXSID5052832 Clint NA 2.607 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052832 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052832 Vd NA 12.76 L/kg 1compartment NA NA Rat Human -DTXSID5052832 Days.Css NA 591 Days PBTK NA NA Rat Human -DTXSID5052832 TK.Half.Life NA 527.5 hours 1compartment NA NA Rat Human -DTXSID5052832 Css NA 6.126 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052832 Css NA 25.62 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052832 Css NA 10.8 mg/L PBTK NA 50% Rat Human -DTXSID5052832 Css NA 46.09 mg/L PBTK NA 95% Rat Human -DTXSID5052838 Clint NA 4.564 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052838 Fup NA 0.0485 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052838 Vd NA 0.2888 L/kg 1compartment NA NA Human Human +DTXSID5052620 TK.Half.Life NA 0.7169 hours 1compartment NA NA Rat Human +DTXSID5052620 Css NA 0.01011 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052620 Css NA 0.05479 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052620 Css NA 0.00743 mg/L PBTK NA 50% Rat Human +DTXSID5052620 Css NA 0.03767 mg/L PBTK NA 95% Rat Human +DTXSID5052626 Clint 49.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID5052626 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052626 Vd NA 0.3637 L/kg 1compartment NA NA Human Human +DTXSID5052626 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5052626 TK.Half.Life NA 0.4524 hours 1compartment NA NA Human Human +DTXSID5052626 Css NA 0.04965 mg/L 3compartmentss NA 50% Human Human +DTXSID5052626 Css NA 0.3808 mg/L 3compartmentss NA 95% Human Human +DTXSID5052626 Css NA 0.03211 mg/L PBTK NA 50% Human Human +DTXSID5052626 Css NA 0.2368 mg/L PBTK NA 95% Human Human +DTXSID5052626 Clint 49.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID5052626 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052626 Vd NA 0.3494 L/kg 1compartment NA NA Rat Human +DTXSID5052626 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5052626 TK.Half.Life NA 0.2224 hours 1compartment NA NA Rat Human +DTXSID5052626 Css NA 0.006606 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052626 Css NA 0.03739 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052626 Css NA 0.004189 mg/L PBTK NA 50% Rat Human +DTXSID5052626 Css NA 0.02271 mg/L PBTK NA 95% Rat Human +DTXSID5052672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052672 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052672 Vd NA 2.386 L/kg 1compartment NA NA Human Human +DTXSID5052672 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5052672 TK.Half.Life NA 5.594 hours 1compartment NA NA Human Human +DTXSID5052672 Css NA 0.1874 mg/L 3compartmentss NA 50% Human Human +DTXSID5052672 Css NA 1.197 mg/L 3compartmentss NA 95% Human Human +DTXSID5052672 Css NA 0.137 mg/L PBTK NA 50% Human Human +DTXSID5052672 Css NA 0.8301 mg/L PBTK NA 95% Human Human +DTXSID5052672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052672 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052672 Vd NA 1.826 L/kg 1compartment NA NA Rat Human +DTXSID5052672 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5052672 TK.Half.Life NA 1.651 hours 1compartment NA NA Rat Human +DTXSID5052672 Css NA 0.02362 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052672 Css NA 0.1186 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052672 Css NA 0.01716 mg/L PBTK NA 50% Rat Human +DTXSID5052672 Css NA 0.0834 mg/L PBTK NA 95% Rat Human +DTXSID5052676 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052676 Fup 0.00333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052676 Vd NA 2.968 L/kg 1compartment NA NA Human Human +DTXSID5052676 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID5052676 TK.Half.Life NA 88.33 hours 1compartment NA NA Human Human +DTXSID5052676 Css NA 3.303 mg/L 3compartmentss NA 50% Human Human +DTXSID5052676 Css NA 22.43 mg/L 3compartmentss NA 95% Human Human +DTXSID5052676 Css NA 2.249 mg/L PBTK NA 50% Human Human +DTXSID5052676 Css NA 14.45 mg/L PBTK NA 95% Human Human +DTXSID5052676 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052676 Fup 0.00333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052676 Vd NA 2.22 L/kg 1compartment NA NA Rat Human +DTXSID5052676 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID5052676 TK.Half.Life NA 14.32 hours 1compartment NA NA Rat Human +DTXSID5052676 Css NA 0.1632 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052676 Css NA 1.123 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052676 Css NA 0.1081 mg/L PBTK NA 50% Rat Human +DTXSID5052676 Css NA 0.7216 mg/L PBTK NA 95% Rat Human +DTXSID5052838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052838 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052838 Vd NA 0.4314 L/kg 1compartment NA NA Human Human DTXSID5052838 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5052838 TK.Half.Life NA 4.702 hours 1compartment NA NA Human Human -DTXSID5052838 Css NA 2.748 mg/L 3compartmentss NA 50% Human Human -DTXSID5052838 Css NA 19.72 mg/L 3compartmentss NA 95% Human Human -DTXSID5052838 Css NA 1.687 mg/L PBTK NA 50% Human Human -DTXSID5052838 Css NA 11.62 mg/L PBTK NA 95% Human Human -DTXSID5052838 Clint NA 4.564 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052838 Fup NA 0.0485 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052838 Vd NA 0.2803 L/kg 1compartment NA NA Rat Human +DTXSID5052838 TK.Half.Life NA 0.8929 hours 1compartment NA NA Human Human +DTXSID5052838 Css NA 0.1864 mg/L 3compartmentss NA 50% Human Human +DTXSID5052838 Css NA 1.629 mg/L 3compartmentss NA 95% Human Human +DTXSID5052838 Css NA 0.1244 mg/L PBTK NA 50% Human Human +DTXSID5052838 Css NA 1.017 mg/L PBTK NA 95% Human Human +DTXSID5052838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052838 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052838 Vd NA 0.4222 L/kg 1compartment NA NA Rat Human DTXSID5052838 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5052838 TK.Half.Life NA 2.794 hours 1compartment NA NA Rat Human -DTXSID5052838 Css NA 1.438 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052838 Css NA 7.583 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052838 Css NA 0.8236 mg/L PBTK NA 50% Rat Human -DTXSID5052838 Css NA 4.174 mg/L PBTK NA 95% Rat Human -DTXSID5052884 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052884 Fup NA 0.9622 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5052884 Vd NA 0.7924 L/kg 1compartment NA NA Human Human +DTXSID5052838 TK.Half.Life NA 0.5071 hours 1compartment NA NA Rat Human +DTXSID5052838 Css NA 0.0247 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052838 Css NA 0.1548 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052838 Css NA 0.01609 mg/L PBTK NA 50% Rat Human +DTXSID5052838 Css NA 0.09282 mg/L PBTK NA 95% Rat Human +DTXSID5052884 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052884 Fup 0.728 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5052884 Vd NA 0.6779 L/kg 1compartment NA NA Human Human DTXSID5052884 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5052884 TK.Half.Life NA 5.332 hours 1compartment NA NA Human Human -DTXSID5052884 Css NA 0.8868 mg/L 3compartmentss NA 50% Human Human -DTXSID5052884 Css NA 4.853 mg/L 3compartmentss NA 95% Human Human -DTXSID5052884 Css NA 0.7418 mg/L PBTK NA 50% Human Human -DTXSID5052884 Css NA 3.244 mg/L PBTK NA 95% Human Human -DTXSID5052884 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052884 Fup NA 0.9622 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5052884 Vd NA 0.8247 L/kg 1compartment NA NA Rat Human +DTXSID5052884 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human +DTXSID5052884 Css NA 0.9179 mg/L 3compartmentss NA 50% Human Human +DTXSID5052884 Css NA 5.699 mg/L 3compartmentss NA 95% Human Human +DTXSID5052884 Css NA 0.7426 mg/L PBTK NA 50% Human Human +DTXSID5052884 Css NA 3.719 mg/L PBTK NA 95% Human Human +DTXSID5052884 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052884 Fup 0.728 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5052884 Vd NA 0.7035 L/kg 1compartment NA NA Rat Human DTXSID5052884 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5052884 TK.Half.Life NA 1.89 hours 1compartment NA NA Rat Human -DTXSID5052884 Css NA 0.224 mg/L 3compartmentss NA 50% Rat Human -DTXSID5052884 Css NA 1.195 mg/L 3compartmentss NA 95% Rat Human -DTXSID5052884 Css NA 0.1832 mg/L PBTK NA 50% Rat Human -DTXSID5052884 Css NA 0.7288 mg/L PBTK NA 95% Rat Human -DTXSID5057620 Clint NA 12.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057620 Fup NA 0.1831 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057620 Vd NA 3.784 L/kg 1compartment NA NA Human Human +DTXSID5052884 TK.Half.Life NA 2.131 hours 1compartment NA NA Rat Human +DTXSID5052884 Css NA 0.01736 mg/L 3compartmentss NA 50% Rat Human +DTXSID5052884 Css NA 0.138 mg/L 3compartmentss NA 95% Rat Human +DTXSID5052884 Css NA 0.01358 mg/L PBTK NA 50% Rat Human +DTXSID5052884 Css NA 0.08945 mg/L PBTK NA 95% Rat Human +DTXSID5057620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057620 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057620 Vd NA 0.5164 L/kg 1compartment NA NA Human Human DTXSID5057620 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057620 TK.Half.Life NA 7.528 hours 1compartment NA NA Human Human -DTXSID5057620 Css NA 0.1269 mg/L 3compartmentss NA 50% Human Human -DTXSID5057620 Css NA 0.9452 mg/L 3compartmentss NA 95% Human Human -DTXSID5057620 Css NA 0.1339 mg/L PBTK NA 50% Human Human -DTXSID5057620 Css NA 0.8181 mg/L PBTK NA 95% Human Human -DTXSID5057620 Clint NA 12.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057620 Fup NA 0.1831 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057620 Vd NA 3.78 L/kg 1compartment NA NA Rat Human +DTXSID5057620 TK.Half.Life NA 1.08 hours 1compartment NA NA Human Human +DTXSID5057620 Css NA 0.1677 mg/L 3compartmentss NA 50% Human Human +DTXSID5057620 Css NA 1.396 mg/L 3compartmentss NA 95% Human Human +DTXSID5057620 Css NA 0.1069 mg/L PBTK NA 50% Human Human +DTXSID5057620 Css NA 0.8495 mg/L PBTK NA 95% Human Human +DTXSID5057620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057620 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057620 Vd NA 0.4596 L/kg 1compartment NA NA Rat Human DTXSID5057620 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057620 TK.Half.Life NA 4.138 hours 1compartment NA NA Rat Human -DTXSID5057620 Css NA 0.06684 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057620 Css NA 0.3725 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057620 Css NA 0.06913 mg/L PBTK NA 50% Rat Human -DTXSID5057620 Css NA 0.3119 mg/L PBTK NA 95% Rat Human -DTXSID5057622 Clint NA 26.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057622 Fup NA 0.1511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057622 Vd NA 3.306 L/kg 1compartment NA NA Human Human +DTXSID5057620 TK.Half.Life NA 0.5484 hours 1compartment NA NA Rat Human +DTXSID5057620 Css NA 0.008161 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057620 Css NA 0.07483 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057620 Css NA 0.00506 mg/L PBTK NA 50% Rat Human +DTXSID5057620 Css NA 0.04407 mg/L PBTK NA 95% Rat Human +DTXSID5057622 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057622 Fup 0.067 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057622 Vd NA 1.9 L/kg 1compartment NA NA Human Human DTXSID5057622 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057622 TK.Half.Life NA 3.538 hours 1compartment NA NA Human Human -DTXSID5057622 Css NA 0.05522 mg/L 3compartmentss NA 50% Human Human -DTXSID5057622 Css NA 0.5446 mg/L 3compartmentss NA 95% Human Human -DTXSID5057622 Css NA 0.05855 mg/L PBTK NA 50% Human Human -DTXSID5057622 Css NA 0.4552 mg/L PBTK NA 95% Human Human -DTXSID5057622 Clint NA 26.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057622 Fup NA 0.1511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057622 Vd NA 3.308 L/kg 1compartment NA NA Rat Human +DTXSID5057622 TK.Half.Life NA 11.21 hours 1compartment NA NA Human Human +DTXSID5057622 Css NA 0.7321 mg/L 3compartmentss NA 50% Human Human +DTXSID5057622 Css NA 6.018 mg/L 3compartmentss NA 95% Human Human +DTXSID5057622 Css NA 0.5694 mg/L PBTK NA 50% Human Human +DTXSID5057622 Css NA 4.04 mg/L PBTK NA 95% Human Human +DTXSID5057622 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057622 Fup 0.067 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057622 Vd NA 1.874 L/kg 1compartment NA NA Rat Human DTXSID5057622 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057622 TK.Half.Life NA 1.973 hours 1compartment NA NA Rat Human -DTXSID5057622 Css NA 0.0305 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057622 Css NA 0.2378 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057622 Css NA 0.03149 mg/L PBTK NA 50% Rat Human -DTXSID5057622 Css NA 0.1854 mg/L PBTK NA 95% Rat Human -DTXSID5057624 Clint NA 18.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057624 Fup NA 0.6979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057624 Vd NA 1.839 L/kg 1compartment NA NA Human Human +DTXSID5057622 TK.Half.Life NA 6.911 hours 1compartment NA NA Rat Human +DTXSID5057622 Css NA 0.0918 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057622 Css NA 0.569 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057622 Css NA 0.07088 mg/L PBTK NA 50% Rat Human +DTXSID5057622 Css NA 0.3676 mg/L PBTK NA 95% Rat Human +DTXSID5057624 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057624 Fup 0.475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057624 Vd NA 1.43 L/kg 1compartment NA NA Human Human DTXSID5057624 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057624 TK.Half.Life NA 1.447 hours 1compartment NA NA Human Human -DTXSID5057624 Css NA 0.03118 mg/L 3compartmentss NA 50% Human Human -DTXSID5057624 Css NA 0.3294 mg/L 3compartmentss NA 95% Human Human -DTXSID5057624 Css NA 0.0297 mg/L PBTK NA 50% Human Human -DTXSID5057624 Css NA 0.2539 mg/L PBTK NA 95% Human Human -DTXSID5057624 Clint NA 18.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057624 Fup NA 0.6979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057624 Vd NA 1.806 L/kg 1compartment NA NA Rat Human +DTXSID5057624 TK.Half.Life NA 1.364 hours 1compartment NA NA Human Human +DTXSID5057624 Css NA 0.03654 mg/L 3compartmentss NA 50% Human Human +DTXSID5057624 Css NA 0.3276 mg/L 3compartmentss NA 95% Human Human +DTXSID5057624 Css NA 0.03126 mg/L PBTK NA 50% Human Human +DTXSID5057624 Css NA 0.2446 mg/L PBTK NA 95% Human Human +DTXSID5057624 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057624 Fup 0.475 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057624 Vd NA 1.397 L/kg 1compartment NA NA Rat Human DTXSID5057624 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057624 TK.Half.Life NA 0.7117 hours 1compartment NA NA Rat Human -DTXSID5057624 Css NA 0.01554 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057624 Css NA 0.1533 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057624 Css NA 0.01489 mg/L PBTK NA 50% Rat Human -DTXSID5057624 Css NA 0.1076 mg/L PBTK NA 95% Rat Human -DTXSID5057626 Clint NA 20.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057626 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057626 Vd NA 3.316 L/kg 1compartment NA NA Human Human +DTXSID5057624 TK.Half.Life NA 0.6816 hours 1compartment NA NA Rat Human +DTXSID5057624 Css NA 0.004499 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057624 Css NA 0.03332 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057624 Css NA 0.003909 mg/L PBTK NA 50% Rat Human +DTXSID5057624 Css NA 0.02388 mg/L PBTK NA 95% Rat Human +DTXSID5057626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057626 Fup 0.0509 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057626 Vd NA 3.344 L/kg 1compartment NA NA Human Human DTXSID5057626 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057626 TK.Half.Life NA 6.527 hours 1compartment NA NA Human Human -DTXSID5057626 Css NA 0.158 mg/L 3compartmentss NA 50% Human Human -DTXSID5057626 Css NA 1.194 mg/L 3compartmentss NA 95% Human Human -DTXSID5057626 Css NA 0.1232 mg/L PBTK NA 50% Human Human -DTXSID5057626 Css NA 0.8678 mg/L PBTK NA 95% Human Human -DTXSID5057626 Clint NA 20.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057626 Fup NA 0.0486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057626 Vd NA 2.738 L/kg 1compartment NA NA Rat Human +DTXSID5057626 TK.Half.Life NA 6.301 hours 1compartment NA NA Human Human +DTXSID5057626 Css NA 0.1409 mg/L 3compartmentss NA 50% Human Human +DTXSID5057626 Css NA 1.057 mg/L 3compartmentss NA 95% Human Human +DTXSID5057626 Css NA 0.1101 mg/L PBTK NA 50% Human Human +DTXSID5057626 Css NA 0.7731 mg/L PBTK NA 95% Human Human +DTXSID5057626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057626 Fup 0.0509 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057626 Vd NA 2.762 L/kg 1compartment NA NA Rat Human DTXSID5057626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057626 TK.Half.Life NA 1.912 hours 1compartment NA NA Rat Human -DTXSID5057626 Css NA 0.08796 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057626 Css NA 0.5256 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057626 Css NA 0.06654 mg/L PBTK NA 50% Rat Human -DTXSID5057626 Css NA 0.373 mg/L PBTK NA 95% Rat Human -DTXSID5057628 Clint NA 197.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057628 Fup NA 0.1359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057628 Vd NA 1.809 L/kg 1compartment NA NA Human Human +DTXSID5057626 TK.Half.Life NA 1.839 hours 1compartment NA NA Rat Human +DTXSID5057626 Css NA 0.01822 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057626 Css NA 0.1173 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057626 Css NA 0.01427 mg/L PBTK NA 50% Rat Human +DTXSID5057626 Css NA 0.08409 mg/L PBTK NA 95% Rat Human +DTXSID5057628 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057628 Fup 0.275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057628 Vd NA 2.302 L/kg 1compartment NA NA Human Human DTXSID5057628 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057628 TK.Half.Life NA 1.793 hours 1compartment NA NA Human Human -DTXSID5057628 Css NA 0.02771 mg/L 3compartmentss NA 50% Human Human -DTXSID5057628 Css NA 0.2227 mg/L 3compartmentss NA 95% Human Human -DTXSID5057628 Css NA 0.01918 mg/L PBTK NA 50% Human Human -DTXSID5057628 Css NA 0.1462 mg/L PBTK NA 95% Human Human -DTXSID5057628 Clint NA 197.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057628 Fup NA 0.1359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057628 Vd NA 1.391 L/kg 1compartment NA NA Rat Human +DTXSID5057628 TK.Half.Life NA 4.281 hours 1compartment NA NA Human Human +DTXSID5057628 Css NA 0.1298 mg/L 3compartmentss NA 50% Human Human +DTXSID5057628 Css NA 0.8644 mg/L 3compartmentss NA 95% Human Human +DTXSID5057628 Css NA 0.09762 mg/L PBTK NA 50% Human Human +DTXSID5057628 Css NA 0.6054 mg/L PBTK NA 95% Human Human +DTXSID5057628 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057628 Fup 0.275 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057628 Vd NA 1.785 L/kg 1compartment NA NA Rat Human DTXSID5057628 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057628 TK.Half.Life NA 0.6156 hours 1compartment NA NA Rat Human -DTXSID5057628 Css NA 0.01562 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057628 Css NA 0.09931 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057628 Css NA 0.01021 mg/L PBTK NA 50% Rat Human -DTXSID5057628 Css NA 0.06117 mg/L PBTK NA 95% Rat Human -DTXSID5057670 Clint NA 65.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5057628 TK.Half.Life NA 1.352 hours 1compartment NA NA Rat Human +DTXSID5057628 Css NA 0.01628 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057628 Css NA 0.08236 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057628 Css NA 0.01225 mg/L PBTK NA 50% Rat Human +DTXSID5057628 Css NA 0.0582 mg/L PBTK NA 95% Rat Human +DTXSID5057670 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5057670 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5057670 Vd NA 2.634 L/kg 1compartment NA NA Human Human +DTXSID5057670 Vd NA 3.084 L/kg 1compartment NA NA Human Human DTXSID5057670 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057670 TK.Half.Life NA 1.295 hours 1compartment NA NA Human Human -DTXSID5057670 Css NA 0.007272 mg/L 3compartmentss NA 50% Human Human -DTXSID5057670 Css NA 0.09288 mg/L 3compartmentss NA 95% Human Human -DTXSID5057670 Css NA 0.008392 mg/L PBTK NA 50% Human Human -DTXSID5057670 Css NA 0.0772 mg/L PBTK NA 95% Human Human -DTXSID5057670 Clint NA 65.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5057670 TK.Half.Life NA 3.35 hours 1compartment NA NA Human Human +DTXSID5057670 Css NA 0.05987 mg/L 3compartmentss NA 50% Human Human +DTXSID5057670 Css NA 0.6659 mg/L 3compartmentss NA 95% Human Human +DTXSID5057670 Css NA 0.07598 mg/L PBTK NA 50% Human Human +DTXSID5057670 Css NA 0.5607 mg/L PBTK NA 95% Human Human +DTXSID5057670 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5057670 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5057670 Vd NA 2.642 L/kg 1compartment NA NA Rat Human +DTXSID5057670 Vd NA 3.098 L/kg 1compartment NA NA Rat Human DTXSID5057670 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057670 TK.Half.Life NA 0.5835 hours 1compartment NA NA Rat Human -DTXSID5057670 Css NA 0.003644 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057670 Css NA 0.04306 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057670 Css NA 0.00429 mg/L PBTK NA 50% Rat Human -DTXSID5057670 Css NA 0.03461 mg/L PBTK NA 95% Rat Human -DTXSID5057672 Clint NA 34.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057672 Fup NA 0.065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057672 Vd NA 1.589 L/kg 1compartment NA NA Human Human +DTXSID5057670 TK.Half.Life NA 1.849 hours 1compartment NA NA Rat Human +DTXSID5057670 Css NA 0.006338 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057670 Css NA 0.06455 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057670 Css NA 0.008526 mg/L PBTK NA 50% Rat Human +DTXSID5057670 Css NA 0.04977 mg/L PBTK NA 95% Rat Human +DTXSID5057672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057672 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057672 Vd NA 2.164 L/kg 1compartment NA NA Human Human DTXSID5057672 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057672 TK.Half.Life NA 3.461 hours 1compartment NA NA Human Human -DTXSID5057672 Css NA 0.214 mg/L 3compartmentss NA 50% Human Human -DTXSID5057672 Css NA 1.712 mg/L 3compartmentss NA 95% Human Human -DTXSID5057672 Css NA 0.1522 mg/L PBTK NA 50% Human Human -DTXSID5057672 Css NA 1.127 mg/L PBTK NA 95% Human Human -DTXSID5057672 Clint NA 34.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057672 Fup NA 0.065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057672 Vd NA 1.494 L/kg 1compartment NA NA Rat Human +DTXSID5057672 TK.Half.Life NA 4.061 hours 1compartment NA NA Human Human +DTXSID5057672 Css NA 0.1526 mg/L 3compartmentss NA 50% Human Human +DTXSID5057672 Css NA 1.394 mg/L 3compartmentss NA 95% Human Human +DTXSID5057672 Css NA 0.123 mg/L PBTK NA 50% Human Human +DTXSID5057672 Css NA 0.9966 mg/L PBTK NA 95% Human Human +DTXSID5057672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057672 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057672 Vd NA 2.084 L/kg 1compartment NA NA Rat Human DTXSID5057672 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057672 TK.Half.Life NA 1.877 hours 1compartment NA NA Rat Human -DTXSID5057672 Css NA 0.1208 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057672 Css NA 0.7701 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057672 Css NA 0.08154 mg/L PBTK NA 50% Rat Human -DTXSID5057672 Css NA 0.4788 mg/L PBTK NA 95% Rat Human -DTXSID5057674 Clint NA 15.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057674 Fup NA 0.0596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057674 Vd NA 1.448 L/kg 1compartment NA NA Human Human +DTXSID5057672 TK.Half.Life NA 2.211 hours 1compartment NA NA Rat Human +DTXSID5057672 Css NA 0.0194 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057672 Css NA 0.1389 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057672 Css NA 0.01553 mg/L PBTK NA 50% Rat Human +DTXSID5057672 Css NA 0.09318 mg/L PBTK NA 95% Rat Human +DTXSID5057674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057674 Fup 0.0773 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057674 Vd NA 1.539 L/kg 1compartment NA NA Human Human DTXSID5057674 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057674 TK.Half.Life NA 7.714 hours 1compartment NA NA Human Human -DTXSID5057674 Css NA 0.7468 mg/L 3compartmentss NA 50% Human Human -DTXSID5057674 Css NA 5.313 mg/L 3compartmentss NA 95% Human Human -DTXSID5057674 Css NA 0.4797 mg/L PBTK NA 50% Human Human -DTXSID5057674 Css NA 3.231 mg/L PBTK NA 95% Human Human -DTXSID5057674 Clint NA 15.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057674 Fup NA 0.0596 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057674 Vd NA 1.094 L/kg 1compartment NA NA Rat Human +DTXSID5057674 TK.Half.Life NA 5.307 hours 1compartment NA NA Human Human +DTXSID5057674 Css NA 0.4073 mg/L 3compartmentss NA 50% Human Human +DTXSID5057674 Css NA 2.927 mg/L 3compartmentss NA 95% Human Human +DTXSID5057674 Css NA 0.2663 mg/L PBTK NA 50% Human Human +DTXSID5057674 Css NA 1.835 mg/L PBTK NA 95% Human Human +DTXSID5057674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057674 Fup 0.0773 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057674 Vd NA 1.167 L/kg 1compartment NA NA Rat Human DTXSID5057674 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057674 TK.Half.Life NA 3.029 hours 1compartment NA NA Rat Human -DTXSID5057674 Css NA 0.4135 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057674 Css NA 2.335 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057674 Css NA 0.2505 mg/L PBTK NA 50% Rat Human -DTXSID5057674 Css NA 1.352 mg/L PBTK NA 95% Rat Human -DTXSID5057676 Clint NA 1.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057676 Fup NA 0.1476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057676 Vd NA 1.925 L/kg 1compartment NA NA Human Human -DTXSID5057676 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5057676 TK.Half.Life NA 39.18 hours 1compartment NA NA Human Human -DTXSID5057676 Css NA 2.539 mg/L 3compartmentss NA 50% Human Human -DTXSID5057676 Css NA 12.08 mg/L 3compartmentss NA 95% Human Human -DTXSID5057676 Css NA 1.855 mg/L PBTK NA 50% Human Human -DTXSID5057676 Css NA 7.786 mg/L PBTK NA 95% Human Human -DTXSID5057676 Clint NA 1.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057676 Fup NA 0.1476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057676 Vd NA 1.605 L/kg 1compartment NA NA Rat Human -DTXSID5057676 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID5057676 TK.Half.Life NA 13.28 hours 1compartment NA NA Rat Human -DTXSID5057676 Css NA 1.065 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057676 Css NA 4.142 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057676 Css NA 0.746 mg/L PBTK NA 50% Rat Human -DTXSID5057676 Css NA 2.469 mg/L PBTK NA 95% Rat Human -DTXSID5057678 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID5057674 TK.Half.Life NA 2.029 hours 1compartment NA NA Rat Human +DTXSID5057674 Css NA 0.0528 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057674 Css NA 0.3032 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057674 Css NA 0.03379 mg/L PBTK NA 50% Rat Human +DTXSID5057674 Css NA 0.1851 mg/L PBTK NA 95% Rat Human +DTXSID5057676 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057676 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057676 Vd NA 2.416 L/kg 1compartment NA NA Human Human +DTXSID5057676 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5057676 TK.Half.Life NA 4.03 hours 1compartment NA NA Human Human +DTXSID5057676 Css NA 0.1065 mg/L 3compartmentss NA 50% Human Human +DTXSID5057676 Css NA 0.7504 mg/L 3compartmentss NA 95% Human Human +DTXSID5057676 Css NA 0.08536 mg/L PBTK NA 50% Human Human +DTXSID5057676 Css NA 0.5432 mg/L PBTK NA 95% Human Human +DTXSID5057676 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057676 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057676 Vd NA 2.03 L/kg 1compartment NA NA Rat Human +DTXSID5057676 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5057676 TK.Half.Life NA 1.53 hours 1compartment NA NA Rat Human +DTXSID5057676 Css NA 0.01342 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057676 Css NA 0.06962 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057676 Css NA 0.01089 mg/L PBTK NA 50% Rat Human +DTXSID5057676 Css NA 0.05189 mg/L PBTK NA 95% Rat Human +DTXSID5057678 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID5057678 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID5057678 Vd NA 3.156 L/kg 1compartment NA NA Human Human -DTXSID5057678 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID5057678 TK.Half.Life NA 53.82 hours 1compartment NA NA Human Human -DTXSID5057678 Css NA 1.977 mg/L 3compartmentss NA 50% Human Human -DTXSID5057678 Css NA 12.74 mg/L 3compartmentss NA 95% Human Human -DTXSID5057678 Css NA 1.393 mg/L PBTK NA 50% Human Human -DTXSID5057678 Css NA 8.726 mg/L PBTK NA 95% Human Human -DTXSID5057678 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5057678 Vd NA 3.161 L/kg 1compartment NA NA Human Human +DTXSID5057678 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID5057678 TK.Half.Life NA 37.65 hours 1compartment NA NA Human Human +DTXSID5057678 Css NA 1.308 mg/L 3compartmentss NA 50% Human Human +DTXSID5057678 Css NA 8.541 mg/L 3compartmentss NA 95% Human Human +DTXSID5057678 Css NA 0.9182 mg/L PBTK NA 50% Human Human +DTXSID5057678 Css NA 5.693 mg/L PBTK NA 95% Human Human +DTXSID5057678 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5057678 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID5057678 Vd NA 2.374 L/kg 1compartment NA NA Rat Human -DTXSID5057678 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID5057678 TK.Half.Life NA 7.359 hours 1compartment NA NA Rat Human -DTXSID5057678 Css NA 1.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057678 Css NA 5.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057678 Css NA 0.7524 mg/L PBTK NA 50% Rat Human -DTXSID5057678 Css NA 3.868 mg/L PBTK NA 95% Rat Human -DTXSID5057701 Clint NA 69.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057701 Fup NA 0.6339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057701 Vd NA 1.785 L/kg 1compartment NA NA Human Human +DTXSID5057678 Vd NA 2.38 L/kg 1compartment NA NA Rat Human +DTXSID5057678 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID5057678 TK.Half.Life NA 5.332 hours 1compartment NA NA Rat Human +DTXSID5057678 Css NA 0.1734 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057678 Css NA 1.021 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057678 Css NA 0.1202 mg/L PBTK NA 50% Rat Human +DTXSID5057678 Css NA 0.687 mg/L PBTK NA 95% Rat Human +DTXSID5057701 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057701 Fup 0.502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057701 Vd NA 0.8696 L/kg 1compartment NA NA Human Human DTXSID5057701 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057701 TK.Half.Life NA 1.255 hours 1compartment NA NA Human Human -DTXSID5057701 Css NA 0.01234 mg/L 3compartmentss NA 50% Human Human -DTXSID5057701 Css NA 0.1288 mg/L 3compartmentss NA 95% Human Human -DTXSID5057701 Css NA 0.01068 mg/L PBTK NA 50% Human Human -DTXSID5057701 Css NA 0.09205 mg/L PBTK NA 95% Human Human -DTXSID5057701 Clint NA 69.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057701 Fup NA 0.6339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057701 Vd NA 1.491 L/kg 1compartment NA NA Rat Human +DTXSID5057701 TK.Half.Life NA 1.424 hours 1compartment NA NA Human Human +DTXSID5057701 Css NA 0.1154 mg/L 3compartmentss NA 50% Human Human +DTXSID5057701 Css NA 0.9033 mg/L 3compartmentss NA 95% Human Human +DTXSID5057701 Css NA 0.09988 mg/L PBTK NA 50% Human Human +DTXSID5057701 Css NA 0.6482 mg/L PBTK NA 95% Human Human +DTXSID5057701 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057701 Fup 0.502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057701 Vd NA 0.8738 L/kg 1compartment NA NA Rat Human DTXSID5057701 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057701 TK.Half.Life NA 0.4643 hours 1compartment NA NA Rat Human -DTXSID5057701 Css NA 0.006472 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057701 Css NA 0.0616 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057701 Css NA 0.005518 mg/L PBTK NA 50% Rat Human -DTXSID5057701 Css NA 0.04283 mg/L PBTK NA 95% Rat Human -DTXSID5057703 Clint NA 940.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057703 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057703 Vd NA 2.139 L/kg 1compartment NA NA Human Human +DTXSID5057701 TK.Half.Life NA 0.7965 hours 1compartment NA NA Rat Human +DTXSID5057701 Css NA 0.01324 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057701 Css NA 0.08517 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057701 Css NA 0.01161 mg/L PBTK NA 50% Rat Human +DTXSID5057701 Css NA 0.05777 mg/L PBTK NA 95% Rat Human +DTXSID5057703 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057703 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057703 Vd NA 0.3683 L/kg 1compartment NA NA Human Human DTXSID5057703 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057703 TK.Half.Life NA 2.45 hours 1compartment NA NA Human Human -DTXSID5057703 Css NA 0.04682 mg/L 3compartmentss NA 50% Human Human -DTXSID5057703 Css NA 0.3648 mg/L 3compartmentss NA 95% Human Human -DTXSID5057703 Css NA 0.03012 mg/L PBTK NA 50% Human Human -DTXSID5057703 Css NA 0.2265 mg/L PBTK NA 95% Human Human -DTXSID5057703 Clint NA 940.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057703 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057703 Vd NA 1.606 L/kg 1compartment NA NA Rat Human +DTXSID5057703 TK.Half.Life NA 1.778 hours 1compartment NA NA Human Human +DTXSID5057703 Css NA 0.5528 mg/L 3compartmentss NA 50% Human Human +DTXSID5057703 Css NA 3.902 mg/L 3compartmentss NA 95% Human Human +DTXSID5057703 Css NA 0.348 mg/L PBTK NA 50% Human Human +DTXSID5057703 Css NA 2.324 mg/L PBTK NA 95% Human Human +DTXSID5057703 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057703 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057703 Vd NA 0.3736 L/kg 1compartment NA NA Rat Human DTXSID5057703 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057703 TK.Half.Life NA 0.7975 hours 1compartment NA NA Rat Human -DTXSID5057703 Css NA 0.02571 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057703 Css NA 0.1885 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057703 Css NA 0.01579 mg/L PBTK NA 50% Rat Human -DTXSID5057703 Css NA 0.1093 mg/L PBTK NA 95% Rat Human -DTXSID5057705 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057705 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057705 Vd NA 0.7764 L/kg 1compartment NA NA Human Human +DTXSID5057703 TK.Half.Life NA 1.082 hours 1compartment NA NA Rat Human +DTXSID5057703 Css NA 0.02511 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057703 Css NA 0.2022 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057703 Css NA 0.01529 mg/L PBTK NA 50% Rat Human +DTXSID5057703 Css NA 0.118 mg/L PBTK NA 95% Rat Human +DTXSID5057705 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057705 Fup 0.836 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057705 Vd NA 0.6564 L/kg 1compartment NA NA Human Human DTXSID5057705 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057705 TK.Half.Life NA 5.026 hours 1compartment NA NA Human Human -DTXSID5057705 Css NA 0.8293 mg/L 3compartmentss NA 50% Human Human -DTXSID5057705 Css NA 5.565 mg/L 3compartmentss NA 95% Human Human -DTXSID5057705 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID5057705 Css NA 3.599 mg/L PBTK NA 95% Human Human -DTXSID5057705 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057705 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057705 Vd NA 0.8122 L/kg 1compartment NA NA Rat Human +DTXSID5057705 TK.Half.Life NA 5.082 hours 1compartment NA NA Human Human +DTXSID5057705 Css NA 0.9588 mg/L 3compartmentss NA 50% Human Human +DTXSID5057705 Css NA 5.629 mg/L 3compartmentss NA 95% Human Human +DTXSID5057705 Css NA 0.7707 mg/L PBTK NA 50% Human Human +DTXSID5057705 Css NA 3.617 mg/L PBTK NA 95% Human Human +DTXSID5057705 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057705 Fup 0.836 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057705 Vd NA 0.6942 L/kg 1compartment NA NA Rat Human DTXSID5057705 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057705 TK.Half.Life NA 1.791 hours 1compartment NA NA Rat Human -DTXSID5057705 Css NA 0.2086 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057705 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057705 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID5057705 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID5057709 Clint NA 0.1033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057709 Fup NA 0.1599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057709 Vd NA 0.3908 L/kg 1compartment NA NA Human Human +DTXSID5057705 TK.Half.Life NA 1.831 hours 1compartment NA NA Rat Human +DTXSID5057705 Css NA 0.05707 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057705 Css NA 0.3255 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057705 Css NA 0.04602 mg/L PBTK NA 50% Rat Human +DTXSID5057705 Css NA 0.2006 mg/L PBTK NA 95% Rat Human +DTXSID5057709 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057709 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057709 Vd NA 0.6368 L/kg 1compartment NA NA Human Human DTXSID5057709 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5057709 TK.Half.Life NA 13.49 hours 1compartment NA NA Human Human -DTXSID5057709 Css NA 4.548 mg/L 3compartmentss NA 50% Human Human -DTXSID5057709 Css NA 19.98 mg/L 3compartmentss NA 95% Human Human -DTXSID5057709 Css NA 2.979 mg/L PBTK NA 50% Human Human -DTXSID5057709 Css NA 11.95 mg/L PBTK NA 95% Human Human -DTXSID5057709 Clint NA 0.1033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057709 Fup NA 0.1599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057709 Vd NA 0.3911 L/kg 1compartment NA NA Rat Human +DTXSID5057709 TK.Half.Life NA 10.33 hours 1compartment NA NA Human Human +DTXSID5057709 Css NA 1.661 mg/L 3compartmentss NA 50% Human Human +DTXSID5057709 Css NA 7.556 mg/L 3compartmentss NA 95% Human Human +DTXSID5057709 Css NA 1.292 mg/L PBTK NA 50% Human Human +DTXSID5057709 Css NA 4.958 mg/L PBTK NA 95% Human Human +DTXSID5057709 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057709 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057709 Vd NA 0.6423 L/kg 1compartment NA NA Rat Human DTXSID5057709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057709 TK.Half.Life NA 4.976 hours 1compartment NA NA Rat Human -DTXSID5057709 Css NA 1.404 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057709 Css NA 5.118 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057709 Css NA 0.8664 mg/L PBTK NA 50% Rat Human -DTXSID5057709 Css NA 2.883 mg/L PBTK NA 95% Rat Human -DTXSID5057751 Clint NA 9.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057751 Fup NA 0.1182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057751 Vd NA 3.74 L/kg 1compartment NA NA Human Human +DTXSID5057709 TK.Half.Life NA 3.551 hours 1compartment NA NA Rat Human +DTXSID5057709 Css NA 0.1061 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057709 Css NA 0.4188 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057709 Css NA 0.08204 mg/L PBTK NA 50% Rat Human +DTXSID5057709 Css NA 0.2624 mg/L PBTK NA 95% Rat Human +DTXSID5057751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057751 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057751 Vd NA 5.206 L/kg 1compartment NA NA Human Human DTXSID5057751 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057751 TK.Half.Life NA 8.327 hours 1compartment NA NA Human Human -DTXSID5057751 Css NA 0.178 mg/L 3compartmentss NA 50% Human Human -DTXSID5057751 Css NA 1.54 mg/L 3compartmentss NA 95% Human Human -DTXSID5057751 Css NA 0.1785 mg/L PBTK NA 50% Human Human -DTXSID5057751 Css NA 1.244 mg/L PBTK NA 95% Human Human -DTXSID5057751 Clint NA 9.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057751 Fup NA 0.1182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057751 Vd NA 3.568 L/kg 1compartment NA NA Rat Human +DTXSID5057751 TK.Half.Life NA 4.6 hours 1compartment NA NA Human Human +DTXSID5057751 Css NA 0.03086 mg/L 3compartmentss NA 50% Human Human +DTXSID5057751 Css NA 0.2637 mg/L 3compartmentss NA 95% Human Human +DTXSID5057751 Css NA 0.04118 mg/L PBTK NA 50% Human Human +DTXSID5057751 Css NA 0.2812 mg/L PBTK NA 95% Human Human +DTXSID5057751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057751 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057751 Vd NA 5.05 L/kg 1compartment NA NA Rat Human DTXSID5057751 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057751 TK.Half.Life NA 4.051 hours 1compartment NA NA Rat Human -DTXSID5057751 Css NA 0.09474 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057751 Css NA 0.6385 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057751 Css NA 0.093 mg/L PBTK NA 50% Rat Human -DTXSID5057751 Css NA 0.4922 mg/L PBTK NA 95% Rat Human -DTXSID5057753 Clint NA 32.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057753 Fup NA 0.0037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057753 Vd NA 0.7123 L/kg 1compartment NA NA Human Human +DTXSID5057751 TK.Half.Life NA 2.026 hours 1compartment NA NA Rat Human +DTXSID5057751 Css NA 0.003734 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057751 Css NA 0.02542 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057751 Css NA 0.005275 mg/L PBTK NA 50% Rat Human +DTXSID5057751 Css NA 0.02909 mg/L PBTK NA 95% Rat Human +DTXSID5057753 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057753 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057753 Vd NA 1.922 L/kg 1compartment NA NA Human Human DTXSID5057753 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5057753 TK.Half.Life NA 16.62 hours 1compartment NA NA Human Human -DTXSID5057753 Css NA 4.261 mg/L 3compartmentss NA 50% Human Human -DTXSID5057753 Css NA 35.38 mg/L 3compartmentss NA 95% Human Human -DTXSID5057753 Css NA 2.51 mg/L PBTK NA 50% Human Human -DTXSID5057753 Css NA 20.62 mg/L PBTK NA 95% Human Human -DTXSID5057753 Clint NA 32.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057753 Fup NA 0.0037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057753 Vd NA 0.5244 L/kg 1compartment NA NA Rat Human -DTXSID5057753 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057753 TK.Half.Life NA 7.822 hours 1compartment NA NA Rat Human -DTXSID5057753 Css NA 2.47 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057753 Css NA 15.53 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057753 Css NA 1.364 mg/L PBTK NA 50% Rat Human -DTXSID5057753 Css NA 8.536 mg/L PBTK NA 95% Rat Human -DTXSID5057755 Clint NA 16.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057755 Fup NA 0.2669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057755 Vd NA 0.7657 L/kg 1compartment NA NA Human Human +DTXSID5057753 TK.Half.Life NA 22.08 hours 1compartment NA NA Human Human +DTXSID5057753 Css NA 1.542 mg/L 3compartmentss NA 50% Human Human +DTXSID5057753 Css NA 13.03 mg/L 3compartmentss NA 95% Human Human +DTXSID5057753 Css NA 0.9856 mg/L PBTK NA 50% Human Human +DTXSID5057753 Css NA 7.826 mg/L PBTK NA 95% Human Human +DTXSID5057753 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057753 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057753 Vd NA 1.425 L/kg 1compartment NA NA Rat Human +DTXSID5057753 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID5057753 TK.Half.Life NA 7.311 hours 1compartment NA NA Rat Human +DTXSID5057753 Css NA 0.0782 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057753 Css NA 0.7229 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057753 Css NA 0.04828 mg/L PBTK NA 50% Rat Human +DTXSID5057753 Css NA 0.4233 mg/L PBTK NA 95% Rat Human +DTXSID5057755 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057755 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057755 Vd NA 0.766 L/kg 1compartment NA NA Human Human DTXSID5057755 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057755 TK.Half.Life NA 1.216 hours 1compartment NA NA Human Human -DTXSID5057755 Css NA 0.106 mg/L 3compartmentss NA 50% Human Human -DTXSID5057755 Css NA 0.7482 mg/L 3compartmentss NA 95% Human Human -DTXSID5057755 Css NA 0.07586 mg/L PBTK NA 50% Human Human -DTXSID5057755 Css NA 0.489 mg/L PBTK NA 95% Human Human -DTXSID5057755 Clint NA 16.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057755 Fup NA 0.2669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID5057755 TK.Half.Life NA 1.067 hours 1compartment NA NA Human Human +DTXSID5057755 Css NA 0.07733 mg/L 3compartmentss NA 50% Human Human +DTXSID5057755 Css NA 0.573 mg/L 3compartmentss NA 95% Human Human +DTXSID5057755 Css NA 0.05478 mg/L PBTK NA 50% Human Human +DTXSID5057755 Css NA 0.383 mg/L PBTK NA 95% Human Human +DTXSID5057755 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057755 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID5057755 Vd NA 0.6824 L/kg 1compartment NA NA Rat Human DTXSID5057755 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057755 TK.Half.Life NA 0.5889 hours 1compartment NA NA Rat Human -DTXSID5057755 Css NA 0.05762 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057755 Css NA 0.3015 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057755 Css NA 0.03911 mg/L PBTK NA 50% Rat Human -DTXSID5057755 Css NA 0.1914 mg/L PBTK NA 95% Rat Human -DTXSID5057757 Clint NA 4.245 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057757 Fup NA 0.2139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057757 Vd NA 0.4717 L/kg 1compartment NA NA Human Human +DTXSID5057755 TK.Half.Life NA 0.5052 hours 1compartment NA NA Rat Human +DTXSID5057755 Css NA 0.009708 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057755 Css NA 0.0526 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057755 Css NA 0.006886 mg/L PBTK NA 50% Rat Human +DTXSID5057755 Css NA 0.03476 mg/L PBTK NA 95% Rat Human +DTXSID5057757 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057757 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057757 Vd NA 0.7435 L/kg 1compartment NA NA Human Human DTXSID5057757 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057757 TK.Half.Life NA 2.075 hours 1compartment NA NA Human Human -DTXSID5057757 Css NA 0.4766 mg/L 3compartmentss NA 50% Human Human -DTXSID5057757 Css NA 2.624 mg/L 3compartmentss NA 95% Human Human -DTXSID5057757 Css NA 0.3186 mg/L PBTK NA 50% Human Human -DTXSID5057757 Css NA 1.655 mg/L PBTK NA 95% Human Human -DTXSID5057757 Clint NA 4.245 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057757 Fup NA 0.2139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057757 Vd NA 0.4531 L/kg 1compartment NA NA Rat Human +DTXSID5057757 TK.Half.Life NA 1.757 hours 1compartment NA NA Human Human +DTXSID5057757 Css NA 0.1981 mg/L 3compartmentss NA 50% Human Human +DTXSID5057757 Css NA 1.239 mg/L 3compartmentss NA 95% Human Human +DTXSID5057757 Css NA 0.1459 mg/L PBTK NA 50% Human Human +DTXSID5057757 Css NA 0.8345 mg/L PBTK NA 95% Human Human +DTXSID5057757 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057757 Fup 0.331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057757 Vd NA 0.6819 L/kg 1compartment NA NA Rat Human DTXSID5057757 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057757 TK.Half.Life NA 1.152 hours 1compartment NA NA Rat Human -DTXSID5057757 Css NA 0.2421 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057757 Css NA 0.9425 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057757 Css NA 0.1536 mg/L PBTK NA 50% Rat Human -DTXSID5057757 Css NA 0.556 mg/L PBTK NA 95% Rat Human -DTXSID5057759 Clint NA 13.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057759 Fup NA 0.0553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057759 Vd NA 1.524 L/kg 1compartment NA NA Human Human +DTXSID5057757 TK.Half.Life NA 0.9015 hours 1compartment NA NA Rat Human +DTXSID5057757 Css NA 0.0235 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057757 Css NA 0.1094 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057757 Css NA 0.01704 mg/L PBTK NA 50% Rat Human +DTXSID5057757 Css NA 0.07069 mg/L PBTK NA 95% Rat Human +DTXSID5057759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057759 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057759 Vd NA 2.115 L/kg 1compartment NA NA Human Human DTXSID5057759 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057759 TK.Half.Life NA 6.822 hours 1compartment NA NA Human Human -DTXSID5057759 Css NA 0.5918 mg/L 3compartmentss NA 50% Human Human -DTXSID5057759 Css NA 4.668 mg/L 3compartmentss NA 95% Human Human -DTXSID5057759 Css NA 0.4204 mg/L PBTK NA 50% Human Human -DTXSID5057759 Css NA 3.052 mg/L PBTK NA 95% Human Human -DTXSID5057759 Clint NA 13.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057759 Fup NA 0.0553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057759 Vd NA 1.469 L/kg 1compartment NA NA Rat Human +DTXSID5057759 TK.Half.Life NA 4.211 hours 1compartment NA NA Human Human +DTXSID5057759 Css NA 0.1722 mg/L 3compartmentss NA 50% Human Human +DTXSID5057759 Css NA 1.508 mg/L 3compartmentss NA 95% Human Human +DTXSID5057759 Css NA 0.1386 mg/L PBTK NA 50% Human Human +DTXSID5057759 Css NA 1.049 mg/L PBTK NA 95% Human Human +DTXSID5057759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057759 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057759 Vd NA 2.076 L/kg 1compartment NA NA Rat Human DTXSID5057759 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057759 TK.Half.Life NA 4.073 hours 1compartment NA NA Rat Human -DTXSID5057759 Css NA 0.3211 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057759 Css NA 2.075 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057759 Css NA 0.2164 mg/L PBTK NA 50% Rat Human -DTXSID5057759 Css NA 1.251 mg/L PBTK NA 95% Rat Human -DTXSID5057830 Clint NA 3.158 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057830 Fup NA 0.296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057830 Vd NA 3.762 L/kg 1compartment NA NA Human Human -DTXSID5057830 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID5057830 TK.Half.Life NA 42.21 hours 1compartment NA NA Human Human -DTXSID5057830 Css NA 1.058 mg/L 3compartmentss NA 50% Human Human -DTXSID5057830 Css NA 5.511 mg/L 3compartmentss NA 95% Human Human -DTXSID5057830 Css NA 0.9268 mg/L PBTK NA 50% Human Human -DTXSID5057830 Css NA 4.39 mg/L PBTK NA 95% Human Human -DTXSID5057830 Clint NA 3.158 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057830 Fup NA 0.296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057830 Vd NA 3.159 L/kg 1compartment NA NA Rat Human -DTXSID5057830 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID5057830 TK.Half.Life NA 8.617 hours 1compartment NA NA Rat Human -DTXSID5057830 Css NA 0.5352 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057830 Css NA 1.951 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057830 Css NA 0.4585 mg/L PBTK NA 50% Rat Human -DTXSID5057830 Css NA 1.487 mg/L PBTK NA 95% Rat Human -DTXSID5057832 Clint NA 52.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057832 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057832 Vd NA 2.608 L/kg 1compartment NA NA Human Human +DTXSID5057759 TK.Half.Life NA 2.411 hours 1compartment NA NA Rat Human +DTXSID5057759 Css NA 0.02195 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057759 Css NA 0.1587 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057759 Css NA 0.01757 mg/L PBTK NA 50% Rat Human +DTXSID5057759 Css NA 0.109 mg/L PBTK NA 95% Rat Human +DTXSID5057830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057830 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057830 Vd NA 3.628 L/kg 1compartment NA NA Human Human +DTXSID5057830 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5057830 TK.Half.Life NA 8.439 hours 1compartment NA NA Human Human +DTXSID5057830 Css NA 0.1671 mg/L 3compartmentss NA 50% Human Human +DTXSID5057830 Css NA 1.1 mg/L 3compartmentss NA 95% Human Human +DTXSID5057830 Css NA 0.1441 mg/L PBTK NA 50% Human Human +DTXSID5057830 Css NA 0.8759 mg/L PBTK NA 95% Human Human +DTXSID5057830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057830 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057830 Vd NA 3.056 L/kg 1compartment NA NA Rat Human +DTXSID5057830 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5057830 TK.Half.Life NA 2.294 hours 1compartment NA NA Rat Human +DTXSID5057830 Css NA 0.02097 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057830 Css NA 0.1121 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057830 Css NA 0.01822 mg/L PBTK NA 50% Rat Human +DTXSID5057830 Css NA 0.08927 mg/L PBTK NA 95% Rat Human +DTXSID5057832 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057832 Fup 0.0314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057832 Vd NA 1.616 L/kg 1compartment NA NA Human Human DTXSID5057832 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID5057832 TK.Half.Life NA 10.21 hours 1compartment NA NA Human Human -DTXSID5057832 Css NA 0.444 mg/L 3compartmentss NA 50% Human Human -DTXSID5057832 Css NA 3.019 mg/L 3compartmentss NA 95% Human Human -DTXSID5057832 Css NA 0.2992 mg/L PBTK NA 50% Human Human -DTXSID5057832 Css NA 1.982 mg/L PBTK NA 95% Human Human -DTXSID5057832 Clint NA 52.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057832 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057832 Vd NA 1.953 L/kg 1compartment NA NA Rat Human +DTXSID5057832 TK.Half.Life NA 10.96 hours 1compartment NA NA Human Human +DTXSID5057832 Css NA 0.9894 mg/L 3compartmentss NA 50% Human Human +DTXSID5057832 Css NA 8.899 mg/L 3compartmentss NA 95% Human Human +DTXSID5057832 Css NA 0.6236 mg/L PBTK NA 50% Human Human +DTXSID5057832 Css NA 5.498 mg/L PBTK NA 95% Human Human +DTXSID5057832 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057832 Fup 0.0314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057832 Vd NA 1.205 L/kg 1compartment NA NA Rat Human DTXSID5057832 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057832 TK.Half.Life NA 2.53 hours 1compartment NA NA Rat Human -DTXSID5057832 Css NA 0.2516 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057832 Css NA 1.334 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057832 Css NA 0.1612 mg/L PBTK NA 50% Rat Human -DTXSID5057832 Css NA 0.8405 mg/L PBTK NA 95% Rat Human -DTXSID5057834 Clint NA 12.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057834 Fup NA 0.0418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057834 Vd NA 2.369 L/kg 1compartment NA NA Human Human -DTXSID5057834 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID5057834 TK.Half.Life NA 28.12 hours 1compartment NA NA Human Human -DTXSID5057834 Css NA 1.684 mg/L 3compartmentss NA 50% Human Human -DTXSID5057834 Css NA 10.96 mg/L 3compartmentss NA 95% Human Human -DTXSID5057834 Css NA 1.116 mg/L PBTK NA 50% Human Human -DTXSID5057834 Css NA 7.009 mg/L PBTK NA 95% Human Human -DTXSID5057834 Clint NA 12.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057834 Fup NA 0.0418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057834 Vd NA 1.772 L/kg 1compartment NA NA Rat Human -DTXSID5057834 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID5057834 TK.Half.Life NA 7.503 hours 1compartment NA NA Rat Human -DTXSID5057834 Css NA 0.9258 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057834 Css NA 4.72 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057834 Css NA 0.5835 mg/L PBTK NA 50% Rat Human -DTXSID5057834 Css NA 2.823 mg/L PBTK NA 95% Rat Human -DTXSID5057836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057836 Fup NA 0.3549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057836 Vd NA 1.148 L/kg 1compartment NA NA Human Human -DTXSID5057836 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID5057836 TK.Half.Life NA 20.93 hours 1compartment NA NA Human Human -DTXSID5057836 Css NA 1.891 mg/L 3compartmentss NA 50% Human Human -DTXSID5057836 Css NA 8.041 mg/L 3compartmentss NA 95% Human Human -DTXSID5057836 Css NA 1.512 mg/L PBTK NA 50% Human Human -DTXSID5057836 Css NA 5.349 mg/L PBTK NA 95% Human Human -DTXSID5057836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057836 Fup NA 0.3549 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057836 Vd NA 1.157 L/kg 1compartment NA NA Rat Human +DTXSID5057832 TK.Half.Life NA 4.073 hours 1compartment NA NA Rat Human +DTXSID5057832 Css NA 0.1286 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057832 Css NA 0.8762 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057832 Css NA 0.07941 mg/L PBTK NA 50% Rat Human +DTXSID5057832 Css NA 0.5205 mg/L PBTK NA 95% Rat Human +DTXSID5057834 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057834 Fup 0.0259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057834 Vd NA 1.803 L/kg 1compartment NA NA Human Human +DTXSID5057834 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5057834 TK.Half.Life NA 14.65 hours 1compartment NA NA Human Human +DTXSID5057834 Css NA 1.188 mg/L 3compartmentss NA 50% Human Human +DTXSID5057834 Css NA 9.689 mg/L 3compartmentss NA 95% Human Human +DTXSID5057834 Css NA 0.7595 mg/L PBTK NA 50% Human Human +DTXSID5057834 Css NA 5.937 mg/L PBTK NA 95% Human Human +DTXSID5057834 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057834 Fup 0.0259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057834 Vd NA 1.341 L/kg 1compartment NA NA Rat Human +DTXSID5057834 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5057834 TK.Half.Life NA 5.1 hours 1compartment NA NA Rat Human +DTXSID5057834 Css NA 0.154 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057834 Css NA 1.088 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057834 Css NA 0.09643 mg/L PBTK NA 50% Rat Human +DTXSID5057834 Css NA 0.6422 mg/L PBTK NA 95% Rat Human +DTXSID5057836 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057836 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057836 Vd NA 0.4581 L/kg 1compartment NA NA Human Human +DTXSID5057836 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5057836 TK.Half.Life NA 7.683 hours 1compartment NA NA Human Human +DTXSID5057836 Css NA 1.042 mg/L 3compartmentss NA 50% Human Human +DTXSID5057836 Css NA 4.764 mg/L 3compartmentss NA 95% Human Human +DTXSID5057836 Css NA 0.746 mg/L PBTK NA 50% Human Human +DTXSID5057836 Css NA 2.974 mg/L PBTK NA 95% Human Human +DTXSID5057836 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057836 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057836 Vd NA 0.4721 L/kg 1compartment NA NA Rat Human DTXSID5057836 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057836 TK.Half.Life NA 7.186 hours 1compartment NA NA Rat Human -DTXSID5057836 Css NA 0.5066 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057836 Css NA 1.906 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057836 Css NA 0.3926 mg/L PBTK NA 50% Rat Human -DTXSID5057836 Css NA 1.178 mg/L PBTK NA 95% Rat Human -DTXSID5057838 Clint NA 6.413 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057838 Fup NA 0.0887 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID5057838 Vd NA 1.912 L/kg 1compartment NA NA Human Human -DTXSID5057838 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID5057838 TK.Half.Life NA 16.95 hours 1compartment NA NA Human Human -DTXSID5057838 Css NA 1.218 mg/L 3compartmentss NA 50% Human Human -DTXSID5057838 Css NA 7.603 mg/L 3compartmentss NA 95% Human Human -DTXSID5057838 Css NA 0.8272 mg/L PBTK NA 50% Human Human -DTXSID5057838 Css NA 4.9 mg/L PBTK NA 95% Human Human -DTXSID5057838 Clint NA 6.413 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057838 Fup NA 0.0887 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID5057838 Vd NA 1.492 L/kg 1compartment NA NA Rat Human +DTXSID5057836 TK.Half.Life NA 2.696 hours 1compartment NA NA Rat Human +DTXSID5057836 Css NA 0.005629 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057836 Css NA 0.02455 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057836 Css NA 0.003819 mg/L PBTK NA 50% Rat Human +DTXSID5057836 Css NA 0.01481 mg/L PBTK NA 95% Rat Human +DTXSID5057838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057838 Fup 0.0748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057838 Vd NA 1.756 L/kg 1compartment NA NA Human Human +DTXSID5057838 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5057838 TK.Half.Life NA 6.307 hours 1compartment NA NA Human Human +DTXSID5057838 Css NA 0.4214 mg/L 3compartmentss NA 50% Human Human +DTXSID5057838 Css NA 3.082 mg/L 3compartmentss NA 95% Human Human +DTXSID5057838 Css NA 0.2828 mg/L PBTK NA 50% Human Human +DTXSID5057838 Css NA 1.966 mg/L PBTK NA 95% Human Human +DTXSID5057838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057838 Fup 0.0748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057838 Vd NA 1.369 L/kg 1compartment NA NA Rat Human DTXSID5057838 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID5057838 TK.Half.Life NA 6.059 hours 1compartment NA NA Rat Human -DTXSID5057838 Css NA 0.6438 mg/L 3compartmentss NA 50% Rat Human -DTXSID5057838 Css NA 3.045 mg/L 3compartmentss NA 95% Rat Human -DTXSID5057838 Css NA 0.4162 mg/L PBTK NA 50% Rat Human -DTXSID5057838 Css NA 1.813 mg/L PBTK NA 95% Rat Human +DTXSID5057838 TK.Half.Life NA 2.424 hours 1compartment NA NA Rat Human +DTXSID5057838 Css NA 0.05478 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057838 Css NA 0.3079 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057838 Css NA 0.03581 mg/L PBTK NA 50% Rat Human +DTXSID5057838 Css NA 0.1917 mg/L PBTK NA 95% Rat Human +DTXSID5057888 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057888 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5057888 Vd NA 0.7064 L/kg 1compartment NA NA Human Human +DTXSID5057888 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5057888 TK.Half.Life NA 1.239 hours 1compartment NA NA Human Human +DTXSID5057888 Css NA 0.06426 mg/L 3compartmentss NA 50% Human Human +DTXSID5057888 Css NA 0.5561 mg/L 3compartmentss NA 95% Human Human +DTXSID5057888 Css NA 0.05184 mg/L PBTK NA 50% Human Human +DTXSID5057888 Css NA 0.3784 mg/L PBTK NA 95% Human Human +DTXSID5057888 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057888 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5057888 Vd NA 0.7148 L/kg 1compartment NA NA Rat Human +DTXSID5057888 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5057888 TK.Half.Life NA 0.6963 hours 1compartment NA NA Rat Human +DTXSID5057888 Css NA 0.0005814 mg/L 3compartmentss NA 50% Rat Human +DTXSID5057888 Css NA 0.004553 mg/L 3compartmentss NA 95% Rat Human +DTXSID5057888 Css NA 0.0004579 mg/L PBTK NA 50% Rat Human +DTXSID5057888 Css NA 0.003005 mg/L PBTK NA 95% Rat Human +DTXSID5058692 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5058692 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5058692 Vd NA 0.6374 L/kg 1compartment NA NA Human Human +DTXSID5058692 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID5058692 TK.Half.Life NA 9.803 hours 1compartment NA NA Human Human +DTXSID5058692 Css NA 1.63 mg/L 3compartmentss NA 50% Human Human +DTXSID5058692 Css NA 7.564 mg/L 3compartmentss NA 95% Human Human +DTXSID5058692 Css NA 1.224 mg/L PBTK NA 50% Human Human +DTXSID5058692 Css NA 4.825 mg/L PBTK NA 95% Human Human +DTXSID5058692 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5058692 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5058692 Vd NA 0.6275 L/kg 1compartment NA NA Rat Human +DTXSID5058692 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5058692 TK.Half.Life NA 3.27 hours 1compartment NA NA Rat Human +DTXSID5058692 Css NA 0.1043 mg/L 3compartmentss NA 50% Rat Human +DTXSID5058692 Css NA 0.4176 mg/L 3compartmentss NA 95% Rat Human +DTXSID5058692 Css NA 0.07788 mg/L PBTK NA 50% Rat Human +DTXSID5058692 Css NA 0.2573 mg/L PBTK NA 95% Rat Human +DTXSID5058694 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5058694 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5058694 Vd NA 2.682 L/kg 1compartment NA NA Human Human +DTXSID5058694 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5058694 TK.Half.Life NA 7.336 hours 1compartment NA NA Human Human +DTXSID5058694 Css NA 0.233 mg/L 3compartmentss NA 50% Human Human +DTXSID5058694 Css NA 1.49 mg/L 3compartmentss NA 95% Human Human +DTXSID5058694 Css NA 0.1708 mg/L PBTK NA 50% Human Human +DTXSID5058694 Css NA 1.048 mg/L PBTK NA 95% Human Human +DTXSID5058694 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5058694 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5058694 Vd NA 2.043 L/kg 1compartment NA NA Rat Human +DTXSID5058694 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5058694 TK.Half.Life NA 1.855 hours 1compartment NA NA Rat Human +DTXSID5058694 Css NA 0.02938 mg/L 3compartmentss NA 50% Rat Human +DTXSID5058694 Css NA 0.1425 mg/L 3compartmentss NA 95% Rat Human +DTXSID5058694 Css NA 0.02134 mg/L PBTK NA 50% Rat Human +DTXSID5058694 Css NA 0.09888 mg/L PBTK NA 95% Rat Human +DTXSID50588686 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50588686 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50588686 Vd NA 0.7765 L/kg 1compartment NA NA Human Human +DTXSID50588686 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50588686 TK.Half.Life NA 1.856 hours 1compartment NA NA Human Human +DTXSID50588686 Css NA 0.2428 mg/L 3compartmentss NA 50% Human Human +DTXSID50588686 Css NA 1.924 mg/L 3compartmentss NA 95% Human Human +DTXSID50588686 Css NA 0.1556 mg/L PBTK NA 50% Human Human +DTXSID50588686 Css NA 1.176 mg/L PBTK NA 95% Human Human +DTXSID50588686 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50588686 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50588686 Vd NA 0.6343 L/kg 1compartment NA NA Rat Human +DTXSID50588686 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50588686 TK.Half.Life NA 0.8616 hours 1compartment NA NA Rat Human +DTXSID50588686 Css NA 0.03165 mg/L 3compartmentss NA 50% Rat Human +DTXSID50588686 Css NA 0.2021 mg/L 3compartmentss NA 95% Rat Human +DTXSID50588686 Css NA 0.01987 mg/L PBTK NA 50% Rat Human +DTXSID50588686 Css NA 0.1185 mg/L PBTK NA 95% Rat Human +DTXSID5059242 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5059242 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5059242 Vd NA 1.764 L/kg 1compartment NA NA Human Human +DTXSID5059242 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID5059242 TK.Half.Life NA 21.57 hours 1compartment NA NA Human Human +DTXSID5059242 Css NA 1.12 mg/L 3compartmentss NA 50% Human Human +DTXSID5059242 Css NA 7.71 mg/L 3compartmentss NA 95% Human Human +DTXSID5059242 Css NA 1.046 mg/L PBTK NA 50% Human Human +DTXSID5059242 Css NA 5.161 mg/L PBTK NA 95% Human Human +DTXSID5059242 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5059242 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5059242 Vd NA 1.734 L/kg 1compartment NA NA Rat Human +DTXSID5059242 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5059242 TK.Half.Life NA 7.025 hours 1compartment NA NA Rat Human +DTXSID5059242 Css NA 0.06809 mg/L 3compartmentss NA 50% Rat Human +DTXSID5059242 Css NA 0.4531 mg/L 3compartmentss NA 95% Rat Human +DTXSID5059242 Css NA 0.06415 mg/L PBTK NA 50% Rat Human +DTXSID5059242 Css NA 0.2919 mg/L PBTK NA 95% Rat Human +DTXSID5060934 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5060934 Fup 0.0212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5060934 Vd NA 3.053 L/kg 1compartment NA NA Human Human +DTXSID5060934 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID5060934 TK.Half.Life NA 68.83 hours 1compartment NA NA Human Human +DTXSID5060934 Css NA 2.752 mg/L 3compartmentss NA 50% Human Human +DTXSID5060934 Css NA 17.63 mg/L 3compartmentss NA 95% Human Human +DTXSID5060934 Css NA 1.894 mg/L PBTK NA 50% Human Human +DTXSID5060934 Css NA 11.83 mg/L PBTK NA 95% Human Human +DTXSID5060934 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5060934 Fup 0.0212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5060934 Vd NA 2.288 L/kg 1compartment NA NA Rat Human +DTXSID5060934 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID5060934 TK.Half.Life NA 10.22 hours 1compartment NA NA Rat Human +DTXSID5060934 Css NA 0.355 mg/L 3compartmentss NA 50% Rat Human +DTXSID5060934 Css NA 1.988 mg/L 3compartmentss NA 95% Rat Human +DTXSID5060934 Css NA 0.2422 mg/L PBTK NA 50% Rat Human +DTXSID5060934 Css NA 1.336 mg/L PBTK NA 95% Rat Human +DTXSID5061532 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5061532 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5061532 Vd NA 2.749 L/kg 1compartment NA NA Human Human +DTXSID5061532 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5061532 TK.Half.Life NA 5.005 hours 1compartment NA NA Human Human +DTXSID5061532 Css NA 0.1216 mg/L 3compartmentss NA 50% Human Human +DTXSID5061532 Css NA 0.8494 mg/L 3compartmentss NA 95% Human Human +DTXSID5061532 Css NA 0.101 mg/L PBTK NA 50% Human Human +DTXSID5061532 Css NA 0.6374 mg/L PBTK NA 95% Human Human +DTXSID5061532 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5061532 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5061532 Vd NA 2.343 L/kg 1compartment NA NA Rat Human +DTXSID5061532 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5061532 TK.Half.Life NA 1.862 hours 1compartment NA NA Rat Human +DTXSID5061532 Css NA 0.0152 mg/L 3compartmentss NA 50% Rat Human +DTXSID5061532 Css NA 0.07967 mg/L 3compartmentss NA 95% Rat Human +DTXSID5061532 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID5061532 Css NA 0.06066 mg/L PBTK NA 95% Rat Human +DTXSID5062184 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5062184 Fup 0.883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5062184 Vd NA 1.004 L/kg 1compartment NA NA Human Human +DTXSID5062184 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5062184 TK.Half.Life NA 0.7412 hours 1compartment NA NA Human Human +DTXSID5062184 Css NA 0.01908 mg/L 3compartmentss NA 50% Human Human +DTXSID5062184 Css NA 0.2253 mg/L 3compartmentss NA 95% Human Human +DTXSID5062184 Css NA 0.01606 mg/L PBTK NA 50% Human Human +DTXSID5062184 Css NA 0.1591 mg/L PBTK NA 95% Human Human +DTXSID5062184 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5062184 Fup 0.883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5062184 Vd NA 0.9585 L/kg 1compartment NA NA Rat Human +DTXSID5062184 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5062184 TK.Half.Life NA 0.3383 hours 1compartment NA NA Rat Human +DTXSID5062184 Css NA 0.0006744 mg/L 3compartmentss NA 50% Rat Human +DTXSID5062184 Css NA 0.008835 mg/L 3compartmentss NA 95% Rat Human +DTXSID5062184 Css NA 0.0005576 mg/L PBTK NA 50% Rat Human +DTXSID5062184 Css NA 0.006295 mg/L PBTK NA 95% Rat Human +DTXSID5062974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5062974 Fup 0.0867 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID5062974 Vd NA 1.319 L/kg 1compartment NA NA Human Human +DTXSID5062974 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID5062974 TK.Half.Life NA 4.007 hours 1compartment NA NA Human Human +DTXSID5062974 Css NA 0.3445 mg/L 3compartmentss NA 50% Human Human +DTXSID5062974 Css NA 2.62 mg/L 3compartmentss NA 95% Human Human +DTXSID5062974 Css NA 0.2247 mg/L PBTK NA 50% Human Human +DTXSID5062974 Css NA 1.623 mg/L PBTK NA 95% Human Human +DTXSID5062974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5062974 Fup 0.0867 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID5062974 Vd NA 1.011 L/kg 1compartment NA NA Rat Human +DTXSID5062974 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID5062974 TK.Half.Life NA 1.624 hours 1compartment NA NA Rat Human +DTXSID5062974 Css NA 0.0449 mg/L 3compartmentss NA 50% Rat Human +DTXSID5062974 Css NA 0.2684 mg/L 3compartmentss NA 95% Rat Human +DTXSID5062974 Css NA 0.02866 mg/L PBTK NA 50% Rat Human +DTXSID5062974 Css NA 0.1639 mg/L PBTK NA 95% Rat Human +DTXSID50648693 Clint 8.105 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50648693 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50648693 Vd NA 1.991 L/kg 1compartment NA NA Human Human +DTXSID50648693 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50648693 TK.Half.Life NA 12.66 hours 1compartment NA NA Human Human +DTXSID50648693 Css NA 0.7892 mg/L 3compartmentss NA 50% Human Human +DTXSID50648693 Css NA 5.053 mg/L 3compartmentss NA 95% Human Human +DTXSID50648693 Css NA 0.5387 mg/L PBTK NA 50% Human Human +DTXSID50648693 Css NA 3.263 mg/L PBTK NA 95% Human Human +DTXSID50648693 Clint 8.105 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50648693 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50648693 Vd NA 1.516 L/kg 1compartment NA NA Rat Human +DTXSID50648693 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50648693 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human +DTXSID50648693 Css NA 0.09773 mg/L 3compartmentss NA 50% Rat Human +DTXSID50648693 Css NA 0.4647 mg/L 3compartmentss NA 95% Rat Human +DTXSID50648693 Css NA 0.06577 mg/L PBTK NA 50% Rat Human +DTXSID50648693 Css NA 0.2926 mg/L PBTK NA 95% Rat Human +DTXSID50648931 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50648931 Fup 0.0197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50648931 Vd NA 1.075 L/kg 1compartment NA NA Human Human +DTXSID50648931 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID50648931 TK.Half.Life NA 18.2 hours 1compartment NA NA Human Human +DTXSID50648931 Css NA 2.7 mg/L 3compartmentss NA 50% Human Human +DTXSID50648931 Css NA 25.48 mg/L 3compartmentss NA 95% Human Human +DTXSID50648931 Css NA 1.764 mg/L PBTK NA 50% Human Human +DTXSID50648931 Css NA 15.31 mg/L PBTK NA 95% Human Human +DTXSID50648931 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50648931 Fup 0.0197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50648931 Vd NA 1.01 L/kg 1compartment NA NA Rat Human +DTXSID50648931 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID50648931 TK.Half.Life NA 10.97 hours 1compartment NA NA Rat Human +DTXSID50648931 Css NA 0.3462 mg/L 3compartmentss NA 50% Rat Human +DTXSID50648931 Css NA 2.667 mg/L 3compartmentss NA 95% Rat Human +DTXSID50648931 Css NA 0.2196 mg/L PBTK NA 50% Rat Human +DTXSID50648931 Css NA 1.544 mg/L PBTK NA 95% Rat Human +DTXSID50701313 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50701313 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50701313 Vd NA 0.9341 L/kg 1compartment NA NA Human Human +DTXSID50701313 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50701313 TK.Half.Life NA 4.469 hours 1compartment NA NA Human Human +DTXSID50701313 Css NA 0.6678 mg/L 3compartmentss NA 50% Human Human +DTXSID50701313 Css NA 6.105 mg/L 3compartmentss NA 95% Human Human +DTXSID50701313 Css NA 0.4142 mg/L PBTK NA 50% Human Human +DTXSID50701313 Css NA 3.634 mg/L PBTK NA 95% Human Human +DTXSID50701313 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50701313 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50701313 Vd NA 0.7073 L/kg 1compartment NA NA Rat Human +DTXSID50701313 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50701313 TK.Half.Life NA 1.967 hours 1compartment NA NA Rat Human +DTXSID50701313 Css NA 0.08686 mg/L 3compartmentss NA 50% Rat Human +DTXSID50701313 Css NA 0.61 mg/L 3compartmentss NA 95% Rat Human +DTXSID50701313 Css NA 0.05238 mg/L PBTK NA 50% Rat Human +DTXSID50701313 Css NA 0.3592 mg/L PBTK NA 95% Rat Human +DTXSID50859181 Clint NA 0.3084 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID50859181 Fup NA 0.5036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID50859181 Vd NA 0.6245 L/kg 1compartment NA NA Human Human +DTXSID50859181 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50859181 TK.Half.Life NA 5.377 hours 1compartment NA NA Human Human +DTXSID50859181 Css NA 0.7896 mg/L 3compartmentss NA 50% Human Human +DTXSID50859181 Css NA 4.194 mg/L 3compartmentss NA 95% Human Human +DTXSID50859181 Css NA 0.6068 mg/L PBTK NA 50% Human Human +DTXSID50859181 Css NA 2.674 mg/L PBTK NA 95% Human Human +DTXSID50859181 Clint NA 0.3084 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID50859181 Fup NA 0.5036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID50859181 Vd NA 0.6309 L/kg 1compartment NA NA Rat Human +DTXSID50859181 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50859181 TK.Half.Life NA 2.223 hours 1compartment NA NA Rat Human +DTXSID50859181 Css NA 0.01808 mg/L 3compartmentss NA 50% Rat Human +DTXSID50859181 Css NA 0.1307 mg/L 3compartmentss NA 95% Rat Human +DTXSID50859181 Css NA 0.01344 mg/L PBTK NA 50% Rat Human +DTXSID50859181 Css NA 0.08269 mg/L PBTK NA 95% Rat Human DTXSID50861300 Clint 2.558 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.31.5.580 NA Human Human DTXSID50861300 Fup 0.016 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Human Human DTXSID50861300 Vd NA 0.9817 L/kg 1compartment NA NA Human Human DTXSID50861300 Days.Css NA 13 Days PBTK NA NA Human Human DTXSID50861300 TK.Half.Life NA 70.07 hours 1compartment NA NA Human Human -DTXSID50861300 Css NA 10.55 mg/L 3compartmentss NA 50% Human Human -DTXSID50861300 Css NA 84.72 mg/L 3compartmentss NA 95% Human Human -DTXSID50861300 Css NA 7.764 mg/L PBTK NA 50% Human Human -DTXSID50861300 Css NA 52.91 mg/L PBTK NA 95% Human Human +DTXSID50861300 Css NA 9.538 mg/L 3compartmentss NA 50% Human Human +DTXSID50861300 Css NA 68.38 mg/L 3compartmentss NA 95% Human Human +DTXSID50861300 Css NA 7.438 mg/L PBTK NA 50% Human Human +DTXSID50861300 Css NA 53.33 mg/L PBTK NA 95% Human Human DTXSID50861300 Clint 132.3 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat DTXSID50861300 Fup 0.03 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat DTXSID50861300 Vd NA 1.007 L/kg 1compartment NA NA Rat Rat DTXSID50861300 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID50861300 TK.Half.Life NA 0.7575 hours 1compartment NA NA Rat Rat -DTXSID50861300 Css NA 0.08137 mg/L 3compartmentss NA 50% Rat Rat -DTXSID50861300 Css NA 0.6712 mg/L 3compartmentss NA 95% Rat Rat -DTXSID50861300 Css NA 0.05537 mg/L PBTK NA 50% Rat Rat -DTXSID50861300 Css NA 0.4064 mg/L PBTK NA 95% Rat Rat +DTXSID50861300 Css NA 0.01655 mg/L 3compartmentss NA 50% Rat Rat +DTXSID50861300 Css NA 0.1264 mg/L 3compartmentss NA 95% Rat Rat +DTXSID50861300 Css NA 0.01337 mg/L PBTK NA 50% Rat Rat +DTXSID50861300 Css NA 0.1021 mg/L PBTK NA 95% Rat Rat +DTXSID50862110 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50862110 Fup 0.22 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50862110 Vd NA 3.906 L/kg 1compartment NA NA Human Human +DTXSID50862110 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50862110 TK.Half.Life NA 10.57 hours 1compartment NA NA Human Human +DTXSID50862110 Css NA 0.1724 mg/L 3compartmentss NA 50% Human Human +DTXSID50862110 Css NA 1.233 mg/L 3compartmentss NA 95% Human Human +DTXSID50862110 Css NA 0.195 mg/L PBTK NA 50% Human Human +DTXSID50862110 Css NA 1.121 mg/L PBTK NA 95% Human Human +DTXSID50862110 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50862110 Fup 0.22 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50862110 Vd NA 3.816 L/kg 1compartment NA NA Rat Human +DTXSID50862110 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50862110 TK.Half.Life NA 5.436 hours 1compartment NA NA Rat Human +DTXSID50862110 Css NA 0.02012 mg/L 3compartmentss NA 50% Rat Human +DTXSID50862110 Css NA 0.1092 mg/L 3compartmentss NA 95% Rat Human +DTXSID50862110 Css NA 0.02356 mg/L PBTK NA 50% Rat Human +DTXSID50862110 Css NA 0.09845 mg/L PBTK NA 95% Rat Human +DTXSID50862695 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50862695 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50862695 Vd NA 2.631 L/kg 1compartment NA NA Human Human +DTXSID50862695 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50862695 TK.Half.Life NA 11.69 hours 1compartment NA NA Human Human +DTXSID50862695 Css NA 0.483 mg/L 3compartmentss NA 50% Human Human +DTXSID50862695 Css NA 3.238 mg/L 3compartmentss NA 95% Human Human +DTXSID50862695 Css NA 0.334 mg/L PBTK NA 50% Human Human +DTXSID50862695 Css NA 2.15 mg/L PBTK NA 95% Human Human +DTXSID50862695 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50862695 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50862695 Vd NA 1.984 L/kg 1compartment NA NA Rat Human +DTXSID50862695 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50862695 TK.Half.Life NA 2.849 hours 1compartment NA NA Rat Human +DTXSID50862695 Css NA 0.06137 mg/L 3compartmentss NA 50% Rat Human +DTXSID50862695 Css NA 0.3241 mg/L 3compartmentss NA 95% Rat Human +DTXSID50862695 Css NA 0.04238 mg/L PBTK NA 50% Rat Human +DTXSID50862695 Css NA 0.2153 mg/L PBTK NA 95% Rat Human +DTXSID50864917 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50864917 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50864917 Vd NA 2.01 L/kg 1compartment NA NA Human Human +DTXSID50864917 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50864917 TK.Half.Life NA 4.463 hours 1compartment NA NA Human Human +DTXSID50864917 Css NA 0.177 mg/L 3compartmentss NA 50% Human Human +DTXSID50864917 Css NA 1.201 mg/L 3compartmentss NA 95% Human Human +DTXSID50864917 Css NA 0.1257 mg/L PBTK NA 50% Human Human +DTXSID50864917 Css NA 0.8282 mg/L PBTK NA 95% Human Human +DTXSID50864917 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50864917 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50864917 Vd NA 1.544 L/kg 1compartment NA NA Rat Human +DTXSID50864917 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50864917 TK.Half.Life NA 1.51 hours 1compartment NA NA Rat Human +DTXSID50864917 Css NA 0.02218 mg/L 3compartmentss NA 50% Rat Human +DTXSID50864917 Css NA 0.1144 mg/L 3compartmentss NA 95% Rat Human +DTXSID50864917 Css NA 0.0158 mg/L PBTK NA 50% Rat Human +DTXSID50864917 Css NA 0.07835 mg/L PBTK NA 95% Rat Human +DTXSID50865484 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50865484 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50865484 Vd NA 2.045 L/kg 1compartment NA NA Human Human +DTXSID50865484 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50865484 TK.Half.Life NA 1.857 hours 1compartment NA NA Human Human +DTXSID50865484 Css NA 0.0352 mg/L 3compartmentss NA 50% Human Human +DTXSID50865484 Css NA 0.3458 mg/L 3compartmentss NA 95% Human Human +DTXSID50865484 Css NA 0.0314 mg/L PBTK NA 50% Human Human +DTXSID50865484 Css NA 0.2556 mg/L PBTK NA 95% Human Human +DTXSID50865484 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50865484 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50865484 Vd NA 1.692 L/kg 1compartment NA NA Rat Human +DTXSID50865484 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50865484 TK.Half.Life NA 0.6836 hours 1compartment NA NA Rat Human +DTXSID50865484 Css NA 0.004194 mg/L 3compartmentss NA 50% Rat Human +DTXSID50865484 Css NA 0.03554 mg/L 3compartmentss NA 95% Rat Human +DTXSID50865484 Css NA 0.003809 mg/L PBTK NA 50% Rat Human +DTXSID50865484 Css NA 0.02576 mg/L PBTK NA 95% Rat Human +DTXSID50868319 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50868319 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50868319 Vd NA 2.528 L/kg 1compartment NA NA Human Human +DTXSID50868319 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50868319 TK.Half.Life NA 4.289 hours 1compartment NA NA Human Human +DTXSID50868319 Css NA 0.12 mg/L 3compartmentss NA 50% Human Human +DTXSID50868319 Css NA 0.9176 mg/L 3compartmentss NA 95% Human Human +DTXSID50868319 Css NA 0.1096 mg/L PBTK NA 50% Human Human +DTXSID50868319 Css NA 0.7078 mg/L PBTK NA 95% Human Human +DTXSID50868319 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50868319 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50868319 Vd NA 2.073 L/kg 1compartment NA NA Rat Human +DTXSID50868319 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50868319 TK.Half.Life NA 1.37 hours 1compartment NA NA Rat Human +DTXSID50868319 Css NA 0.0136 mg/L 3compartmentss NA 50% Rat Human +DTXSID50868319 Css NA 0.07768 mg/L 3compartmentss NA 95% Rat Human +DTXSID50868319 Css NA 0.01271 mg/L PBTK NA 50% Rat Human +DTXSID50868319 Css NA 0.05623 mg/L PBTK NA 95% Rat Human +DTXSID50869063 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50869063 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human +DTXSID50869063 Vd NA 3.242 L/kg 1compartment NA NA Human Human +DTXSID50869063 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50869063 TK.Half.Life NA 12.42 hours 1compartment NA NA Human Human +DTXSID50869063 Css NA 0.3588 mg/L 3compartmentss NA 50% Human Human +DTXSID50869063 Css NA 2.547 mg/L 3compartmentss NA 95% Human Human +DTXSID50869063 Css NA 0.269 mg/L PBTK NA 50% Human Human +DTXSID50869063 Css NA 1.833 mg/L PBTK NA 95% Human Human DTXSID50869063 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID50869063 Fup 1 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID50869063 Vd NA 2.491 L/kg 1compartment NA NA Rat Rat -DTXSID50869063 Days.Css NA 33 Days PBTK NA NA Rat Rat -DTXSID50869063 TK.Half.Life NA 39.54 hours 1compartment NA NA Rat Rat -DTXSID50869063 Css NA 5.052 mg/L 3compartmentss NA 50% Rat Rat -DTXSID50869063 Css NA 13.31 mg/L 3compartmentss NA 95% Rat Rat -DTXSID50869063 Css NA 3.671 mg/L PBTK NA 50% Rat Rat -DTXSID50869063 Css NA 8.289 mg/L PBTK NA 95% Rat Rat +DTXSID50869063 Vd NA 2.492 L/kg 1compartment NA NA Rat Rat +DTXSID50869063 Days.Css NA 35 Days PBTK NA NA Rat Rat +DTXSID50869063 TK.Half.Life NA 40.94 hours 1compartment NA NA Rat Rat +DTXSID50869063 Css NA 1.178 mg/L 3compartmentss NA 50% Rat Rat +DTXSID50869063 Css NA 3.178 mg/L 3compartmentss NA 95% Rat Rat +DTXSID50869063 Css NA 0.8861 mg/L PBTK NA 50% Rat Rat +DTXSID50869063 Css NA 2.045 mg/L PBTK NA 95% Rat Rat DTXSID50870351 Clint 23.62 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID50870351 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID50870351 Vd NA 2.428 L/kg 1compartment NA NA Human Human +DTXSID50870351 Vd NA 2.77 L/kg 1compartment NA NA Human Human DTXSID50870351 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID50870351 TK.Half.Life NA 4.119 hours 1compartment NA NA Human Human -DTXSID50870351 Css NA 0.1148 mg/L 3compartmentss NA 50% Human Human -DTXSID50870351 Css NA 0.7692 mg/L 3compartmentss NA 95% Human Human -DTXSID50870351 Css NA 0.0917 mg/L PBTK NA 50% Human Human -DTXSID50870351 Css NA 0.5711 mg/L PBTK NA 95% Human Human +DTXSID50870351 TK.Half.Life NA 3.403 hours 1compartment NA NA Human Human +DTXSID50870351 Css NA 0.05142 mg/L 3compartmentss NA 50% Human Human +DTXSID50870351 Css NA 0.4195 mg/L 3compartmentss NA 95% Human Human +DTXSID50870351 Css NA 0.04898 mg/L PBTK NA 50% Human Human +DTXSID50870351 Css NA 0.3467 mg/L PBTK NA 95% Human Human DTXSID50870351 Clint 23.62 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID50870351 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID50870351 Vd NA 2.026 L/kg 1compartment NA NA Rat Human +DTXSID50870351 Vd NA 2.687 L/kg 1compartment NA NA Rat Human DTXSID50870351 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID50870351 TK.Half.Life NA 1.539 hours 1compartment NA NA Rat Human -DTXSID50870351 Css NA 0.06242 mg/L 3compartmentss NA 50% Rat Human -DTXSID50870351 Css NA 0.3128 mg/L 3compartmentss NA 95% Rat Human -DTXSID50870351 Css NA 0.04812 mg/L PBTK NA 50% Rat Human -DTXSID50870351 Css NA 0.2304 mg/L PBTK NA 95% Rat Human +DTXSID50870351 TK.Half.Life NA 1.754 hours 1compartment NA NA Rat Human +DTXSID50870351 Css NA 0.00235 mg/L 3compartmentss NA 50% Rat Human +DTXSID50870351 Css NA 0.02214 mg/L 3compartmentss NA 95% Rat Human +DTXSID50870351 Css NA 0.00235 mg/L PBTK NA 50% Rat Human +DTXSID50870351 Css NA 0.01807 mg/L PBTK NA 95% Rat Human +DTXSID50872532 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50872532 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50872532 Vd NA 0.5947 L/kg 1compartment NA NA Human Human +DTXSID50872532 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50872532 TK.Half.Life NA 8.446 hours 1compartment NA NA Human Human +DTXSID50872532 Css NA 1.53 mg/L 3compartmentss NA 50% Human Human +DTXSID50872532 Css NA 7.194 mg/L 3compartmentss NA 95% Human Human +DTXSID50872532 Css NA 1.161 mg/L PBTK NA 50% Human Human +DTXSID50872532 Css NA 4.642 mg/L PBTK NA 95% Human Human +DTXSID50872532 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50872532 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50872532 Vd NA 0.601 L/kg 1compartment NA NA Rat Human +DTXSID50872532 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50872532 TK.Half.Life NA 2.901 hours 1compartment NA NA Rat Human +DTXSID50872532 Css NA 0.09831 mg/L 3compartmentss NA 50% Rat Human +DTXSID50872532 Css NA 0.402 mg/L 3compartmentss NA 95% Rat Human +DTXSID50872532 Css NA 0.07331 mg/L PBTK NA 50% Rat Human +DTXSID50872532 Css NA 0.2471 mg/L PBTK NA 95% Rat Human +DTXSID50872976 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50872976 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50872976 Vd NA 2.334 L/kg 1compartment NA NA Human Human +DTXSID50872976 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50872976 TK.Half.Life NA 4.933 hours 1compartment NA NA Human Human +DTXSID50872976 Css NA 0.1617 mg/L 3compartmentss NA 50% Human Human +DTXSID50872976 Css NA 1.041 mg/L 3compartmentss NA 95% Human Human +DTXSID50872976 Css NA 0.119 mg/L PBTK NA 50% Human Human +DTXSID50872976 Css NA 0.7221 mg/L PBTK NA 95% Human Human +DTXSID50872976 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50872976 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50872976 Vd NA 1.093 L/kg 1compartment NA NA Rat Human +DTXSID50872976 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50872976 TK.Half.Life NA 2.16 hours 1compartment NA NA Rat Human +DTXSID50872976 Css NA 0.06218 mg/L 3compartmentss NA 50% Rat Human +DTXSID50872976 Css NA 0.3757 mg/L 3compartmentss NA 95% Rat Human +DTXSID50872976 Css NA 0.039 mg/L PBTK NA 50% Rat Human +DTXSID50872976 Css NA 0.226 mg/L PBTK NA 95% Rat Human +DTXSID50873206 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50873206 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50873206 Vd NA 3.464 L/kg 1compartment NA NA Human Human +DTXSID50873206 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID50873206 TK.Half.Life NA 70.46 hours 1compartment NA NA Human Human +DTXSID50873206 Css NA 1.259 mg/L 3compartmentss NA 50% Human Human +DTXSID50873206 Css NA 6.7 mg/L 3compartmentss NA 95% Human Human +DTXSID50873206 Css NA 1.606 mg/L PBTK NA 50% Human Human +DTXSID50873206 Css NA 5.663 mg/L PBTK NA 95% Human Human +DTXSID50873206 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50873206 Fup 0.32 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50873206 Vd NA 5.068 L/kg 1compartment NA NA Rat Human +DTXSID50873206 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID50873206 TK.Half.Life NA 21.14 hours 1compartment NA NA Rat Human +DTXSID50873206 Css NA 0.03638 mg/L 3compartmentss NA 50% Rat Human +DTXSID50873206 Css NA 0.3113 mg/L 3compartmentss NA 95% Rat Human +DTXSID50873206 Css NA 0.06462 mg/L PBTK NA 50% Rat Human +DTXSID50873206 Css NA 0.2663 mg/L PBTK NA 95% Rat Human +DTXSID50873362 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50873362 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50873362 Vd NA 5.628 L/kg 1compartment NA NA Human Human +DTXSID50873362 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50873362 TK.Half.Life NA 8.572 hours 1compartment NA NA Human Human +DTXSID50873362 Css NA 0.06329 mg/L 3compartmentss NA 50% Human Human +DTXSID50873362 Css NA 0.5987 mg/L 3compartmentss NA 95% Human Human +DTXSID50873362 Css NA 0.1089 mg/L PBTK NA 50% Human Human +DTXSID50873362 Css NA 0.6767 mg/L PBTK NA 95% Human Human +DTXSID50873362 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50873362 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50873362 Vd NA 3.785 L/kg 1compartment NA NA Rat Human +DTXSID50873362 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50873362 TK.Half.Life NA 5.869 hours 1compartment NA NA Rat Human +DTXSID50873362 Css NA 0.01679 mg/L 3compartmentss NA 50% Rat Human +DTXSID50873362 Css NA 0.09821 mg/L 3compartmentss NA 95% Rat Human +DTXSID50873362 Css NA 0.02203 mg/L PBTK NA 50% Rat Human +DTXSID50873362 Css NA 0.09028 mg/L PBTK NA 95% Rat Human +DTXSID50873367 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50873367 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50873367 Vd NA 19.99 L/kg 1compartment NA NA Human Human +DTXSID50873367 Days.Css NA 63 Days PBTK NA NA Human Human +DTXSID50873367 TK.Half.Life NA 290.1 hours 1compartment NA NA Human Human +DTXSID50873367 Css NA 0.1982 mg/L 3compartmentss NA 50% Human Human +DTXSID50873367 Css NA 2.036 mg/L 3compartmentss NA 95% Human Human +DTXSID50873367 Css NA 1.178 mg/L PBTK NA 50% Human Human +DTXSID50873367 Css NA 4.707 mg/L PBTK NA 95% Human Human +DTXSID50873367 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50873367 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50873367 Vd NA 7.619 L/kg 1compartment NA NA Rat Human +DTXSID50873367 Days.Css NA 29 Days PBTK NA NA Rat Human +DTXSID50873367 TK.Half.Life NA 132.3 hours 1compartment NA NA Rat Human +DTXSID50873367 Css NA 0.1412 mg/L 3compartmentss NA 50% Rat Human +DTXSID50873367 Css NA 1.112 mg/L 3compartmentss NA 95% Rat Human +DTXSID50873367 Css NA 0.2929 mg/L PBTK NA 50% Rat Human +DTXSID50873367 Css NA 1.081 mg/L PBTK NA 95% Rat Human DTXSID50873382 Clint 1.051 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID50873382 Fup 0.011 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID50873382 Vd NA 0.4972 L/kg 1compartment NA NA Human Human DTXSID50873382 Days.Css NA 21 Days PBTK NA NA Human Human DTXSID50873382 TK.Half.Life NA 99.69 hours 1compartment NA NA Human Human -DTXSID50873382 Css NA 35.32 mg/L 3compartmentss NA 50% Human Human -DTXSID50873382 Css NA 244.5 mg/L 3compartmentss NA 95% Human Human -DTXSID50873382 Css NA 20.9 mg/L PBTK NA 50% Human Human -DTXSID50873382 Css NA 140.5 mg/L PBTK NA 95% Human Human +DTXSID50873382 Css NA 34.16 mg/L 3compartmentss NA 50% Human Human +DTXSID50873382 Css NA 235.9 mg/L 3compartmentss NA 95% Human Human +DTXSID50873382 Css NA 20.3 mg/L PBTK NA 50% Human Human +DTXSID50873382 Css NA 137 mg/L PBTK NA 95% Human Human DTXSID50873382 Clint 0.1771 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID50873382 Fup 0.012 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID50873382 Vd NA 0.3974 L/kg 1compartment NA NA Rat Rat DTXSID50873382 Days.Css NA 12 Days PBTK NA NA Rat Rat DTXSID50873382 TK.Half.Life NA 63.13 hours 1compartment NA NA Rat Rat -DTXSID50873382 Css NA 23.4 mg/L 3compartmentss NA 50% Rat Rat -DTXSID50873382 Css NA 127.5 mg/L 3compartmentss NA 95% Rat Rat -DTXSID50873382 Css NA 12.94 mg/L PBTK NA 50% Rat Rat -DTXSID50873382 Css NA 69.15 mg/L PBTK NA 95% Rat Rat +DTXSID50873382 Css NA 5.219 mg/L 3compartmentss NA 50% Rat Rat +DTXSID50873382 Css NA 29.31 mg/L 3compartmentss NA 95% Rat Rat +DTXSID50873382 Css NA 2.986 mg/L PBTK NA 50% Rat Rat +DTXSID50873382 Css NA 16.44 mg/L PBTK NA 95% Rat Rat +DTXSID50873387 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50873387 Fup 0.26 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50873387 Vd NA 3.069 L/kg 1compartment NA NA Human Human +DTXSID50873387 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID50873387 TK.Half.Life NA 22.99 hours 1compartment NA NA Human Human +DTXSID50873387 Css NA 0.799 mg/L 3compartmentss NA 50% Human Human +DTXSID50873387 Css NA 5.097 mg/L 3compartmentss NA 95% Human Human +DTXSID50873387 Css NA 0.5637 mg/L PBTK NA 50% Human Human +DTXSID50873387 Css NA 3.467 mg/L PBTK NA 95% Human Human +DTXSID50873387 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50873387 Fup 0.26 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50873387 Vd NA 2.308 L/kg 1compartment NA NA Rat Human +DTXSID50873387 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID50873387 TK.Half.Life NA 3.701 hours 1compartment NA NA Rat Human +DTXSID50873387 Css NA 0.1016 mg/L 3compartmentss NA 50% Rat Human +DTXSID50873387 Css NA 0.5158 mg/L 3compartmentss NA 95% Rat Human +DTXSID50873387 Css NA 0.07134 mg/L PBTK NA 50% Rat Human +DTXSID50873387 Css NA 0.3476 mg/L PBTK NA 95% Rat Human +DTXSID50880657 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880657 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880657 Vd NA 1.016 L/kg 1compartment NA NA Human Human +DTXSID50880657 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50880657 TK.Half.Life NA 2.161 hours 1compartment NA NA Human Human +DTXSID50880657 Css NA 0.1943 mg/L 3compartmentss NA 50% Human Human +DTXSID50880657 Css NA 1.622 mg/L 3compartmentss NA 95% Human Human +DTXSID50880657 Css NA 0.1298 mg/L PBTK NA 50% Human Human +DTXSID50880657 Css NA 1.005 mg/L PBTK NA 95% Human Human +DTXSID50880657 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880657 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880657 Vd NA 0.8142 L/kg 1compartment NA NA Rat Human +DTXSID50880657 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50880657 TK.Half.Life NA 0.944 hours 1compartment NA NA Rat Human +DTXSID50880657 Css NA 0.02526 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880657 Css NA 0.1565 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880657 Css NA 0.01641 mg/L PBTK NA 50% Rat Human +DTXSID50880657 Css NA 0.09448 mg/L PBTK NA 95% Rat Human +DTXSID50880677 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880677 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880677 Vd NA 1.318 L/kg 1compartment NA NA Human Human +DTXSID50880677 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50880677 TK.Half.Life NA 2.151 hours 1compartment NA NA Human Human +DTXSID50880677 Css NA 0.105 mg/L 3compartmentss NA 50% Human Human +DTXSID50880677 Css NA 0.7193 mg/L 3compartmentss NA 95% Human Human +DTXSID50880677 Css NA 0.07517 mg/L PBTK NA 50% Human Human +DTXSID50880677 Css NA 0.4877 mg/L PBTK NA 95% Human Human +DTXSID50880677 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880677 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880677 Vd NA 1.059 L/kg 1compartment NA NA Rat Human +DTXSID50880677 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50880677 TK.Half.Life NA 0.8807 hours 1compartment NA NA Rat Human +DTXSID50880677 Css NA 0.01329 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880677 Css NA 0.0711 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880677 Css NA 0.009493 mg/L PBTK NA 50% Rat Human +DTXSID50880677 Css NA 0.04694 mg/L PBTK NA 95% Rat Human +DTXSID50880692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880692 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880692 Vd NA 2.865 L/kg 1compartment NA NA Human Human +DTXSID50880692 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50880692 TK.Half.Life NA 11.89 hours 1compartment NA NA Human Human +DTXSID50880692 Css NA 0.3965 mg/L 3compartmentss NA 50% Human Human +DTXSID50880692 Css NA 2.444 mg/L 3compartmentss NA 95% Human Human +DTXSID50880692 Css NA 0.2842 mg/L PBTK NA 50% Human Human +DTXSID50880692 Css NA 1.69 mg/L PBTK NA 95% Human Human +DTXSID50880692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880692 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880692 Vd NA 2.167 L/kg 1compartment NA NA Rat Human +DTXSID50880692 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50880692 TK.Half.Life NA 2.515 hours 1compartment NA NA Rat Human +DTXSID50880692 Css NA 0.05082 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880692 Css NA 0.2459 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880692 Css NA 0.03612 mg/L PBTK NA 50% Rat Human +DTXSID50880692 Css NA 0.1692 mg/L PBTK NA 95% Rat Human +DTXSID50880758 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880758 Fup 0.544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880758 Vd NA 2.203 L/kg 1compartment NA NA Human Human +DTXSID50880758 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50880758 TK.Half.Life NA 3.29 hours 1compartment NA NA Human Human +DTXSID50880758 Css NA 0.0971 mg/L 3compartmentss NA 50% Human Human +DTXSID50880758 Css NA 0.9069 mg/L 3compartmentss NA 95% Human Human +DTXSID50880758 Css NA 0.09515 mg/L PBTK NA 50% Human Human +DTXSID50880758 Css NA 0.6754 mg/L PBTK NA 95% Human Human +DTXSID50880758 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880758 Fup 0.544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880758 Vd NA 2.197 L/kg 1compartment NA NA Rat Human +DTXSID50880758 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50880758 TK.Half.Life NA 1.807 hours 1compartment NA NA Rat Human +DTXSID50880758 Css NA 0.01088 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880758 Css NA 0.08638 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880758 Css NA 0.01111 mg/L PBTK NA 50% Rat Human +DTXSID50880758 Css NA 0.06036 mg/L PBTK NA 95% Rat Human +DTXSID50880773 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880773 Fup 0.7 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880773 Vd NA 1.897 L/kg 1compartment NA NA Human Human +DTXSID50880773 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID50880773 TK.Half.Life NA 19.08 hours 1compartment NA NA Human Human +DTXSID50880773 Css NA 0.933 mg/L 3compartmentss NA 50% Human Human +DTXSID50880773 Css NA 6.772 mg/L 3compartmentss NA 95% Human Human +DTXSID50880773 Css NA 0.9048 mg/L PBTK NA 50% Human Human +DTXSID50880773 Css NA 4.507 mg/L PBTK NA 95% Human Human +DTXSID50880773 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880773 Fup 0.7 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880773 Vd NA 1.815 L/kg 1compartment NA NA Rat Human +DTXSID50880773 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50880773 TK.Half.Life NA 5.839 hours 1compartment NA NA Rat Human +DTXSID50880773 Css NA 0.0554 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880773 Css NA 0.3767 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880773 Css NA 0.0546 mg/L PBTK NA 50% Rat Human +DTXSID50880773 Css NA 0.2463 mg/L PBTK NA 95% Rat Human +DTXSID50880859 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880859 Fup 0.0144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880859 Vd NA 5.222 L/kg 1compartment NA NA Human Human +DTXSID50880859 Days.Css NA 29 Days PBTK NA NA Human Human +DTXSID50880859 TK.Half.Life NA 157.2 hours 1compartment NA NA Human Human +DTXSID50880859 Css NA 1.584 mg/L 3compartmentss NA 50% Human Human +DTXSID50880859 Css NA 10.03 mg/L 3compartmentss NA 95% Human Human +DTXSID50880859 Css NA 1.31 mg/L PBTK NA 50% Human Human +DTXSID50880859 Css NA 8.229 mg/L PBTK NA 95% Human Human +DTXSID50880859 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880859 Fup 0.0144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880859 Vd NA 3.996 L/kg 1compartment NA NA Rat Human +DTXSID50880859 Days.Css NA 17 Days PBTK NA NA Rat Human +DTXSID50880859 TK.Half.Life NA 21.45 hours 1compartment NA NA Rat Human +DTXSID50880859 Css NA 0.01704 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880859 Css NA 0.1035 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880859 Css NA 0.01368 mg/L PBTK NA 50% Rat Human +DTXSID50880859 Css NA 0.08452 mg/L PBTK NA 95% Rat Human +DTXSID50880879 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880879 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880879 Vd NA 2.817 L/kg 1compartment NA NA Human Human +DTXSID50880879 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50880879 TK.Half.Life NA 4 hours 1compartment NA NA Human Human +DTXSID50880879 Css NA 0.08025 mg/L 3compartmentss NA 50% Human Human +DTXSID50880879 Css NA 0.5778 mg/L 3compartmentss NA 95% Human Human +DTXSID50880879 Css NA 0.07145 mg/L PBTK NA 50% Human Human +DTXSID50880879 Css NA 0.4624 mg/L PBTK NA 95% Human Human +DTXSID50880879 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880879 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880879 Vd NA 2.521 L/kg 1compartment NA NA Rat Human +DTXSID50880879 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50880879 TK.Half.Life NA 1.682 hours 1compartment NA NA Rat Human +DTXSID50880879 Css NA 0.009732 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880879 Css NA 0.05451 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880879 Css NA 0.008885 mg/L PBTK NA 50% Rat Human +DTXSID50880879 Css NA 0.0438 mg/L PBTK NA 95% Rat Human +DTXSID50880899 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880899 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880899 Vd NA 0.3622 L/kg 1compartment NA NA Human Human +DTXSID50880899 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50880899 TK.Half.Life NA 8.402 hours 1compartment NA NA Human Human +DTXSID50880899 Css NA 2.729 mg/L 3compartmentss NA 50% Human Human +DTXSID50880899 Css NA 10.55 mg/L 3compartmentss NA 95% Human Human +DTXSID50880899 Css NA 1.841 mg/L PBTK NA 50% Human Human +DTXSID50880899 Css NA 6.523 mg/L PBTK NA 95% Human Human +DTXSID50880899 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880899 Fup 0.279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880899 Vd NA 0.3635 L/kg 1compartment NA NA Rat Human +DTXSID50880899 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50880899 TK.Half.Life NA 2.873 hours 1compartment NA NA Rat Human +DTXSID50880899 Css NA 0.1762 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880899 Css NA 0.5668 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880899 Css NA 0.1164 mg/L PBTK NA 50% Rat Human +DTXSID50880899 Css NA 0.337 mg/L PBTK NA 95% Rat Human +DTXSID50880910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880910 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880910 Vd NA 2.268 L/kg 1compartment NA NA Human Human +DTXSID50880910 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50880910 TK.Half.Life NA 6.796 hours 1compartment NA NA Human Human +DTXSID50880910 Css NA 0.2963 mg/L 3compartmentss NA 50% Human Human +DTXSID50880910 Css NA 2.088 mg/L 3compartmentss NA 95% Human Human +DTXSID50880910 Css NA 0.2072 mg/L PBTK NA 50% Human Human +DTXSID50880910 Css NA 1.401 mg/L PBTK NA 95% Human Human +DTXSID50880910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880910 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880910 Vd NA 1.722 L/kg 1compartment NA NA Rat Human +DTXSID50880910 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50880910 TK.Half.Life NA 2.053 hours 1compartment NA NA Rat Human +DTXSID50880910 Css NA 0.03781 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880910 Css NA 0.2118 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880910 Css NA 0.02608 mg/L PBTK NA 50% Rat Human +DTXSID50880910 Css NA 0.1392 mg/L PBTK NA 95% Rat Human +DTXSID50880915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880915 Fup 0.00908 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50880915 Vd NA 2.157 L/kg 1compartment NA NA Human Human +DTXSID50880915 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID50880915 TK.Half.Life NA 36.58 hours 1compartment NA NA Human Human +DTXSID50880915 Css NA 2.558 mg/L 3compartmentss NA 50% Human Human +DTXSID50880915 Css NA 20.68 mg/L 3compartmentss NA 95% Human Human +DTXSID50880915 Css NA 1.64 mg/L PBTK NA 50% Human Human +DTXSID50880915 Css NA 13.02 mg/L PBTK NA 95% Human Human +DTXSID50880915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880915 Fup 0.00908 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50880915 Vd NA 1.6 L/kg 1compartment NA NA Rat Human +DTXSID50880915 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID50880915 TK.Half.Life NA 10.87 hours 1compartment NA NA Rat Human +DTXSID50880915 Css NA 0.3355 mg/L 3compartmentss NA 50% Rat Human +DTXSID50880915 Css NA 2.209 mg/L 3compartmentss NA 95% Rat Human +DTXSID50880915 Css NA 0.2112 mg/L PBTK NA 50% Rat Human +DTXSID50880915 Css NA 1.36 mg/L PBTK NA 95% Rat Human +DTXSID50881205 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50881205 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50881205 Vd NA 1.995 L/kg 1compartment NA NA Human Human +DTXSID50881205 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50881205 TK.Half.Life NA 2.87 hours 1compartment NA NA Human Human +DTXSID50881205 Css NA 0.08444 mg/L 3compartmentss NA 50% Human Human +DTXSID50881205 Css NA 0.5759 mg/L 3compartmentss NA 95% Human Human +DTXSID50881205 Css NA 0.06557 mg/L PBTK NA 50% Human Human +DTXSID50881205 Css NA 0.413 mg/L PBTK NA 95% Human Human +DTXSID50881205 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50881205 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50881205 Vd NA 1.575 L/kg 1compartment NA NA Rat Human +DTXSID50881205 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50881205 TK.Half.Life NA 1.01 hours 1compartment NA NA Rat Human +DTXSID50881205 Css NA 0.01032 mg/L 3compartmentss NA 50% Rat Human +DTXSID50881205 Css NA 0.05599 mg/L 3compartmentss NA 95% Rat Human +DTXSID50881205 Css NA 0.00805 mg/L PBTK NA 50% Rat Human +DTXSID50881205 Css NA 0.03977 mg/L PBTK NA 95% Rat Human +DTXSID50881220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50881220 Fup 0.0233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50881220 Vd NA 2.959 L/kg 1compartment NA NA Human Human +DTXSID50881220 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID50881220 TK.Half.Life NA 52.71 hours 1compartment NA NA Human Human +DTXSID50881220 Css NA 2.216 mg/L 3compartmentss NA 50% Human Human +DTXSID50881220 Css NA 14.88 mg/L 3compartmentss NA 95% Human Human +DTXSID50881220 Css NA 1.516 mg/L PBTK NA 50% Human Human +DTXSID50881220 Css NA 9.785 mg/L PBTK NA 95% Human Human +DTXSID50881220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50881220 Fup 0.0233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50881220 Vd NA 2.214 L/kg 1compartment NA NA Rat Human +DTXSID50881220 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID50881220 TK.Half.Life NA 8.83 hours 1compartment NA NA Rat Human +DTXSID50881220 Css NA 0.2914 mg/L 3compartmentss NA 50% Rat Human +DTXSID50881220 Css NA 1.606 mg/L 3compartmentss NA 95% Rat Human +DTXSID50881220 Css NA 0.1967 mg/L PBTK NA 50% Rat Human +DTXSID50881220 Css NA 1.069 mg/L PBTK NA 95% Rat Human +DTXSID50895069 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50895069 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID50895069 Vd NA 0.5979 L/kg 1compartment NA NA Human Human +DTXSID50895069 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50895069 TK.Half.Life NA 6.448 hours 1compartment NA NA Human Human +DTXSID50895069 Css NA 0.6773 mg/L 3compartmentss NA 50% Human Human +DTXSID50895069 Css NA 4.812 mg/L 3compartmentss NA 95% Human Human +DTXSID50895069 Css NA 0.5338 mg/L PBTK NA 50% Human Human +DTXSID50895069 Css NA 3.019 mg/L PBTK NA 95% Human Human +DTXSID50895069 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50895069 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID50895069 Vd NA 0.6218 L/kg 1compartment NA NA Rat Human +DTXSID50895069 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50895069 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human +DTXSID50895069 Css NA 0.003546 mg/L 3compartmentss NA 50% Rat Human +DTXSID50895069 Css NA 0.02651 mg/L 3compartmentss NA 95% Rat Human +DTXSID50895069 Css NA 0.002702 mg/L PBTK NA 50% Rat Human +DTXSID50895069 Css NA 0.01586 mg/L PBTK NA 95% Rat Human +DTXSID50904761 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50904761 Fup 0.373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50904761 Vd NA 1.47 L/kg 1compartment NA NA Human Human +DTXSID50904761 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID50904761 TK.Half.Life NA 3.399 hours 1compartment NA NA Human Human +DTXSID50904761 Css NA 0.1862 mg/L 3compartmentss NA 50% Human Human +DTXSID50904761 Css NA 1.206 mg/L 3compartmentss NA 95% Human Human +DTXSID50904761 Css NA 0.1482 mg/L PBTK NA 50% Human Human +DTXSID50904761 Css NA 0.8401 mg/L PBTK NA 95% Human Human +DTXSID50904761 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50904761 Fup 0.373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50904761 Vd NA 1.245 L/kg 1compartment NA NA Rat Human +DTXSID50904761 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID50904761 TK.Half.Life NA 1.479 hours 1compartment NA NA Rat Human +DTXSID50904761 Css NA 0.02183 mg/L 3compartmentss NA 50% Rat Human +DTXSID50904761 Css NA 0.1015 mg/L 3compartmentss NA 95% Rat Human +DTXSID50904761 Css NA 0.01739 mg/L PBTK NA 50% Rat Human +DTXSID50904761 Css NA 0.06934 mg/L PBTK NA 95% Rat Human +DTXSID50957136 Clint 0.09545 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50957136 Fup 0.0966 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID50957136 Vd NA 1.676 L/kg 1compartment NA NA Human Human +DTXSID50957136 Days.Css NA 26 Days PBTK NA NA Human Human +DTXSID50957136 TK.Half.Life NA 132.6 hours 1compartment NA NA Human Human +DTXSID50957136 Css NA 10.44 mg/L 3compartmentss NA 50% Human Human +DTXSID50957136 Css NA 44.63 mg/L 3compartmentss NA 95% Human Human +DTXSID50957136 Css NA 7.094 mg/L PBTK NA 50% Human Human +DTXSID50957136 Css NA 26.91 mg/L PBTK NA 95% Human Human +DTXSID50957136 Clint 0.09545 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50957136 Fup 0.0966 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID50957136 Vd NA 1.326 L/kg 1compartment NA NA Rat Human +DTXSID50957136 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID50957136 TK.Half.Life NA 30.39 hours 1compartment NA NA Rat Human +DTXSID50957136 Css NA 0.729 mg/L 3compartmentss NA 50% Rat Human +DTXSID50957136 Css NA 2.662 mg/L 3compartmentss NA 95% Rat Human +DTXSID50957136 Css NA 0.4848 mg/L PBTK NA 50% Rat Human +DTXSID50957136 Css NA 1.578 mg/L PBTK NA 95% Rat Human +DTXSID50999410 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID50999410 Fup 0.053 NA NA Williamson 2020 NA Human Human +DTXSID50999410 Vd NA 2.348 L/kg 1compartment NA NA Human Human +DTXSID50999410 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID50999410 TK.Half.Life NA 65.27 hours 1compartment NA NA Human Human +DTXSID50999410 Css NA 3.386 mg/L 3compartmentss NA 50% Human Human +DTXSID50999410 Css NA 19.28 mg/L 3compartmentss NA 95% Human Human +DTXSID50999410 Css NA 2.257 mg/L PBTK NA 50% Human Human +DTXSID50999410 Css NA 12.31 mg/L PBTK NA 95% Human Human +DTXSID50999410 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID50999410 Fup 0.053 NA NA Williamson 2020 NA Rat Human +DTXSID50999410 Vd NA 1.76 L/kg 1compartment NA NA Rat Human +DTXSID50999410 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID50999410 TK.Half.Life NA 16.62 hours 1compartment NA NA Rat Human +DTXSID50999410 Css NA 0.1178 mg/L 3compartmentss NA 50% Rat Human +DTXSID50999410 Css NA 0.7571 mg/L 3compartmentss NA 95% Rat Human +DTXSID50999410 Css NA 0.07574 mg/L PBTK NA 50% Rat Human +DTXSID50999410 Css NA 0.4672 mg/L PBTK NA 95% Rat Human +DTXSID601003247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601003247 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601003247 Vd NA 2.29 L/kg 1compartment NA NA Human Human +DTXSID601003247 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID601003247 TK.Half.Life NA 6.129 hours 1compartment NA NA Human Human +DTXSID601003247 Css NA 0.2118 mg/L 3compartmentss NA 50% Human Human +DTXSID601003247 Css NA 1.612 mg/L 3compartmentss NA 95% Human Human +DTXSID601003247 Css NA 0.1775 mg/L PBTK NA 50% Human Human +DTXSID601003247 Css NA 1.21 mg/L PBTK NA 95% Human Human +DTXSID601003247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601003247 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601003247 Vd NA 1.821 L/kg 1compartment NA NA Rat Human +DTXSID601003247 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID601003247 TK.Half.Life NA 2.037 hours 1compartment NA NA Rat Human +DTXSID601003247 Css NA 0.014 mg/L 3compartmentss NA 50% Rat Human +DTXSID601003247 Css NA 0.09815 mg/L 3compartmentss NA 95% Rat Human +DTXSID601003247 Css NA 0.01197 mg/L PBTK NA 50% Rat Human +DTXSID601003247 Css NA 0.07186 mg/L PBTK NA 95% Rat Human +DTXSID601004469 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID601004469 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID601004469 Vd NA 0.4711 L/kg 1compartment NA NA Human Human +DTXSID601004469 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID601004469 TK.Half.Life NA 25.18 hours 1compartment NA NA Human Human +DTXSID601004469 Css NA 8.448 mg/L 3compartmentss NA 50% Human Human +DTXSID601004469 Css NA 75.09 mg/L 3compartmentss NA 95% Human Human +DTXSID601004469 Css NA 5.032 mg/L PBTK NA 50% Human Human +DTXSID601004469 Css NA 43.08 mg/L PBTK NA 95% Human Human +DTXSID601004469 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID601004469 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID601004469 Vd NA 0.3622 L/kg 1compartment NA NA Rat Human +DTXSID601004469 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID601004469 TK.Half.Life NA 12.13 hours 1compartment NA NA Rat Human +DTXSID601004469 Css NA 0.3944 mg/L 3compartmentss NA 50% Rat Human +DTXSID601004469 Css NA 3.894 mg/L 3compartmentss NA 95% Rat Human +DTXSID601004469 Css NA 0.221 mg/L PBTK NA 50% Rat Human +DTXSID601004469 Css NA 2.177 mg/L PBTK NA 95% Rat Human +DTXSID601006172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601006172 Fup 0.0759 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601006172 Vd NA 2.134 L/kg 1compartment NA NA Human Human +DTXSID601006172 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID601006172 TK.Half.Life NA 9.125 hours 1compartment NA NA Human Human +DTXSID601006172 Css NA 0.5029 mg/L 3compartmentss NA 50% Human Human +DTXSID601006172 Css NA 3.532 mg/L 3compartmentss NA 95% Human Human +DTXSID601006172 Css NA 0.3369 mg/L PBTK NA 50% Human Human +DTXSID601006172 Css NA 2.239 mg/L PBTK NA 95% Human Human +DTXSID601006172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601006172 Fup 0.0759 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601006172 Vd NA 1.607 L/kg 1compartment NA NA Rat Human +DTXSID601006172 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID601006172 TK.Half.Life NA 2.845 hours 1compartment NA NA Rat Human +DTXSID601006172 Css NA 0.06578 mg/L 3compartmentss NA 50% Rat Human +DTXSID601006172 Css NA 0.349 mg/L 3compartmentss NA 95% Rat Human +DTXSID601006172 Css NA 0.04324 mg/L PBTK NA 50% Rat Human +DTXSID601006172 Css NA 0.2259 mg/L PBTK NA 95% Rat Human +DTXSID601016509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601016509 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID601016509 Vd NA 0.2294 L/kg 1compartment NA NA Human Human +DTXSID601016509 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID601016509 TK.Half.Life NA 0.595 hours 1compartment NA NA Human Human +DTXSID601016509 Css NA 0.1517 mg/L 3compartmentss NA 50% Human Human +DTXSID601016509 Css NA 1.386 mg/L 3compartmentss NA 95% Human Human +DTXSID601016509 Css NA 0.09121 mg/L PBTK NA 50% Human Human +DTXSID601016509 Css NA 0.826 mg/L PBTK NA 95% Human Human +DTXSID601016509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601016509 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID601016509 Vd NA 0.2306 L/kg 1compartment NA NA Rat Human +DTXSID601016509 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID601016509 TK.Half.Life NA 0.3538 hours 1compartment NA NA Rat Human +DTXSID601016509 Css NA 0.001593 mg/L 3compartmentss NA 50% Rat Human +DTXSID601016509 Css NA 0.01229 mg/L 3compartmentss NA 95% Rat Human +DTXSID601016509 Css NA 0.0009062 mg/L PBTK NA 50% Rat Human +DTXSID601016509 Css NA 0.006812 mg/L PBTK NA 95% Rat Human +DTXSID601024792 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID601024792 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID601024792 Vd NA 1.866 L/kg 1compartment NA NA Human Human +DTXSID601024792 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID601024792 TK.Half.Life NA 4.851 hours 1compartment NA NA Human Human +DTXSID601024792 Css NA 0.1262 mg/L 3compartmentss NA 50% Human Human +DTXSID601024792 Css NA 0.8861 mg/L 3compartmentss NA 95% Human Human +DTXSID601024792 Css NA 0.1011 mg/L PBTK NA 50% Human Human +DTXSID601024792 Css NA 0.6371 mg/L PBTK NA 95% Human Human +DTXSID601024792 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID601024792 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID601024792 Vd NA 1.499 L/kg 1compartment NA NA Rat Human +DTXSID601024792 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID601024792 TK.Half.Life NA 1.778 hours 1compartment NA NA Rat Human +DTXSID601024792 Css NA 0.001354 mg/L 3compartmentss NA 50% Rat Human +DTXSID601024792 Css NA 0.008722 mg/L 3compartmentss NA 95% Rat Human +DTXSID601024792 Css NA 0.001052 mg/L PBTK NA 50% Rat Human +DTXSID601024792 Css NA 0.005933 mg/L PBTK NA 95% Rat Human +DTXSID601027922 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID601027922 Fup 0.022 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID601027922 Vd NA 2.56 L/kg 1compartment NA NA Human Human +DTXSID601027922 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID601027922 TK.Half.Life NA 69.92 hours 1compartment NA NA Human Human +DTXSID601027922 Css NA 3.884 mg/L 3compartmentss NA 50% Human Human +DTXSID601027922 Css NA 28.06 mg/L 3compartmentss NA 95% Human Human +DTXSID601027922 Css NA 2.637 mg/L PBTK NA 50% Human Human +DTXSID601027922 Css NA 17.79 mg/L PBTK NA 95% Human Human +DTXSID601027922 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID601027922 Fup 0.022 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID601027922 Vd NA 1.959 L/kg 1compartment NA NA Rat Human +DTXSID601027922 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID601027922 TK.Half.Life NA 18.13 hours 1compartment NA NA Rat Human +DTXSID601027922 Css NA 0.4892 mg/L 3compartmentss NA 50% Rat Human +DTXSID601027922 Css NA 2.649 mg/L 3compartmentss NA 95% Rat Human +DTXSID601027922 Css NA 0.3262 mg/L PBTK NA 50% Rat Human +DTXSID601027922 Css NA 1.696 mg/L PBTK NA 95% Rat Human +DTXSID601028120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601028120 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601028120 Vd NA 0.3447 L/kg 1compartment NA NA Human Human +DTXSID601028120 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID601028120 TK.Half.Life NA 0.8398 hours 1compartment NA NA Human Human +DTXSID601028120 Css NA 0.08011 mg/L 3compartmentss NA 50% Human Human +DTXSID601028120 Css NA 0.7534 mg/L 3compartmentss NA 95% Human Human +DTXSID601028120 Css NA 0.04942 mg/L PBTK NA 50% Human Human +DTXSID601028120 Css NA 0.462 mg/L PBTK NA 95% Human Human +DTXSID601028120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601028120 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601028120 Vd NA 0.3172 L/kg 1compartment NA NA Rat Human +DTXSID601028120 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID601028120 TK.Half.Life NA 0.453 hours 1compartment NA NA Rat Human +DTXSID601028120 Css NA 0.0006782 mg/L 3compartmentss NA 50% Rat Human +DTXSID601028120 Css NA 0.005117 mg/L 3compartmentss NA 95% Rat Human +DTXSID601028120 Css NA 0.000394 mg/L PBTK NA 50% Rat Human +DTXSID601028120 Css NA 0.002889 mg/L PBTK NA 95% Rat Human +DTXSID601029847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601029847 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601029847 Vd NA 0.9797 L/kg 1compartment NA NA Human Human +DTXSID601029847 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID601029847 TK.Half.Life NA 5.454 hours 1compartment NA NA Human Human +DTXSID601029847 Css NA 0.7758 mg/L 3compartmentss NA 50% Human Human +DTXSID601029847 Css NA 5.81 mg/L 3compartmentss NA 95% Human Human +DTXSID601029847 Css NA 0.5145 mg/L PBTK NA 50% Human Human +DTXSID601029847 Css NA 3.66 mg/L PBTK NA 95% Human Human +DTXSID601029847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601029847 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601029847 Vd NA 0.783 L/kg 1compartment NA NA Rat Human +DTXSID601029847 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID601029847 TK.Half.Life NA 2.594 hours 1compartment NA NA Rat Human +DTXSID601029847 Css NA 0.09646 mg/L 3compartmentss NA 50% Rat Human +DTXSID601029847 Css NA 0.5952 mg/L 3compartmentss NA 95% Rat Human +DTXSID601029847 Css NA 0.06236 mg/L PBTK NA 50% Rat Human +DTXSID601029847 Css NA 0.3611 mg/L PBTK NA 95% Rat Human +DTXSID601101988 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601101988 Fup 0.0981 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601101988 Vd NA 0.4387 L/kg 1compartment NA NA Human Human +DTXSID601101988 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID601101988 TK.Half.Life NA 1.136 hours 1compartment NA NA Human Human +DTXSID601101988 Css NA 0.07148 mg/L 3compartmentss NA 50% Human Human +DTXSID601101988 Css NA 0.7279 mg/L 3compartmentss NA 95% Human Human +DTXSID601101988 Css NA 0.04665 mg/L PBTK NA 50% Human Human +DTXSID601101988 Css NA 0.4553 mg/L PBTK NA 95% Human Human +DTXSID601101988 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601101988 Fup 0.0981 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601101988 Vd NA 0.4306 L/kg 1compartment NA NA Rat Human +DTXSID601101988 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID601101988 TK.Half.Life NA 0.6678 hours 1compartment NA NA Rat Human +DTXSID601101988 Css NA 0.000608 mg/L 3compartmentss NA 50% Rat Human +DTXSID601101988 Css NA 0.004503 mg/L 3compartmentss NA 95% Rat Human +DTXSID601101988 Css NA 0.0003752 mg/L PBTK NA 50% Rat Human +DTXSID601101988 Css NA 0.002624 mg/L PBTK NA 95% Rat Human +DTXSID601103615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601103615 Fup 0.0918 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601103615 Vd NA 0.4014 L/kg 1compartment NA NA Human Human +DTXSID601103615 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID601103615 TK.Half.Life NA 2.763 hours 1compartment NA NA Human Human +DTXSID601103615 Css NA 0.9913 mg/L 3compartmentss NA 50% Human Human +DTXSID601103615 Css NA 6.828 mg/L 3compartmentss NA 95% Human Human +DTXSID601103615 Css NA 0.6198 mg/L PBTK NA 50% Human Human +DTXSID601103615 Css NA 4.114 mg/L PBTK NA 95% Human Human +DTXSID601103615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601103615 Fup 0.0918 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601103615 Vd NA 0.3581 L/kg 1compartment NA NA Rat Human +DTXSID601103615 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID601103615 TK.Half.Life NA 1.499 hours 1compartment NA NA Rat Human +DTXSID601103615 Css NA 0.1237 mg/L 3compartmentss NA 50% Rat Human +DTXSID601103615 Css NA 0.6462 mg/L 3compartmentss NA 95% Rat Human +DTXSID601103615 Css NA 0.07535 mg/L PBTK NA 50% Rat Human +DTXSID601103615 Css NA 0.3726 mg/L PBTK NA 95% Rat Human +DTXSID601303401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601303401 Fup 0.0206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID601303401 Vd NA 2.209 L/kg 1compartment NA NA Human Human +DTXSID601303401 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID601303401 TK.Half.Life NA 11.32 hours 1compartment NA NA Human Human +DTXSID601303401 Css NA 0.6103 mg/L 3compartmentss NA 50% Human Human +DTXSID601303401 Css NA 5.616 mg/L 3compartmentss NA 95% Human Human +DTXSID601303401 Css NA 0.4178 mg/L PBTK NA 50% Human Human +DTXSID601303401 Css NA 3.489 mg/L PBTK NA 95% Human Human +DTXSID601303401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601303401 Fup 0.0206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID601303401 Vd NA 1.78 L/kg 1compartment NA NA Rat Human +DTXSID601303401 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID601303401 TK.Half.Life NA 4.271 hours 1compartment NA NA Rat Human +DTXSID601303401 Css NA 0.04166 mg/L 3compartmentss NA 50% Rat Human +DTXSID601303401 Css NA 0.3895 mg/L 3compartmentss NA 95% Rat Human +DTXSID601303401 Css NA 0.02793 mg/L PBTK NA 50% Rat Human +DTXSID601303401 Css NA 0.2409 mg/L PBTK NA 95% Rat Human +DTXSID60146711 Clint 7.08 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60146711 Fup 0.0662 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60146711 Vd NA 2.886 L/kg 1compartment NA NA Human Human +DTXSID60146711 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID60146711 TK.Half.Life NA 76.14 hours 1compartment NA NA Human Human +DTXSID60146711 Css NA 3.263 mg/L 3compartmentss NA 50% Human Human +DTXSID60146711 Css NA 18.83 mg/L 3compartmentss NA 95% Human Human +DTXSID60146711 Css NA 2.251 mg/L PBTK NA 50% Human Human +DTXSID60146711 Css NA 12.66 mg/L PBTK NA 95% Human Human +DTXSID60146711 Clint 7.08 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60146711 Fup 0.0662 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60146711 Vd NA 2.165 L/kg 1compartment NA NA Rat Human +DTXSID60146711 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID60146711 TK.Half.Life NA 13.38 hours 1compartment NA NA Rat Human +DTXSID60146711 Css NA 0.4132 mg/L 3compartmentss NA 50% Rat Human +DTXSID60146711 Css NA 1.895 mg/L 3compartmentss NA 95% Rat Human +DTXSID60146711 Css NA 0.282 mg/L PBTK NA 50% Rat Human +DTXSID60146711 Css NA 1.278 mg/L PBTK NA 95% Rat Human +DTXSID60147142 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60147142 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60147142 Vd NA 1.25 L/kg 1compartment NA NA Human Human +DTXSID60147142 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60147142 TK.Half.Life NA 1.431 hours 1compartment NA NA Human Human +DTXSID60147142 Css NA 0.05288 mg/L 3compartmentss NA 50% Human Human +DTXSID60147142 Css NA 0.3929 mg/L 3compartmentss NA 95% Human Human +DTXSID60147142 Css NA 0.04132 mg/L PBTK NA 50% Human Human +DTXSID60147142 Css NA 0.2814 mg/L PBTK NA 95% Human Human +DTXSID60147142 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60147142 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60147142 Vd NA 1.061 L/kg 1compartment NA NA Rat Human +DTXSID60147142 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60147142 TK.Half.Life NA 0.6064 hours 1compartment NA NA Rat Human +DTXSID60147142 Css NA 0.006526 mg/L 3compartmentss NA 50% Rat Human +DTXSID60147142 Css NA 0.03981 mg/L 3compartmentss NA 95% Rat Human +DTXSID60147142 Css NA 0.005094 mg/L PBTK NA 50% Rat Human +DTXSID60147142 Css NA 0.02726 mg/L PBTK NA 95% Rat Human +DTXSID60149803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60149803 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60149803 Vd NA 1.348 L/kg 1compartment NA NA Human Human +DTXSID60149803 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60149803 TK.Half.Life NA 1.488 hours 1compartment NA NA Human Human +DTXSID60149803 Css NA 0.04884 mg/L 3compartmentss NA 50% Human Human +DTXSID60149803 Css NA 0.3969 mg/L 3compartmentss NA 95% Human Human +DTXSID60149803 Css NA 0.03903 mg/L PBTK NA 50% Human Human +DTXSID60149803 Css NA 0.2807 mg/L PBTK NA 95% Human Human +DTXSID60149803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60149803 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60149803 Vd NA 1.139 L/kg 1compartment NA NA Rat Human +DTXSID60149803 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60149803 TK.Half.Life NA 0.6189 hours 1compartment NA NA Rat Human +DTXSID60149803 Css NA 0.005962 mg/L 3compartmentss NA 50% Rat Human +DTXSID60149803 Css NA 0.03797 mg/L 3compartmentss NA 95% Rat Human +DTXSID60149803 Css NA 0.00481 mg/L PBTK NA 50% Rat Human +DTXSID60149803 Css NA 0.0263 mg/L PBTK NA 95% Rat Human +DTXSID60154659 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60154659 Fup 0.027 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60154659 Vd NA 0.2982 L/kg 1compartment NA NA Human Human +DTXSID60154659 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60154659 TK.Half.Life NA 6.371 hours 1compartment NA NA Human Human +DTXSID60154659 Css NA 3.337 mg/L 3compartmentss NA 50% Human Human +DTXSID60154659 Css NA 29.23 mg/L 3compartmentss NA 95% Human Human +DTXSID60154659 Css NA 1.997 mg/L PBTK NA 50% Human Human +DTXSID60154659 Css NA 17.13 mg/L PBTK NA 95% Human Human +DTXSID60154659 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60154659 Fup 0.027 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60154659 Vd NA 0.2698 L/kg 1compartment NA NA Rat Human +DTXSID60154659 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60154659 TK.Half.Life NA 3.639 hours 1compartment NA NA Rat Human +DTXSID60154659 Css NA 0.1297 mg/L 3compartmentss NA 50% Rat Human +DTXSID60154659 Css NA 1.225 mg/L 3compartmentss NA 95% Rat Human +DTXSID60154659 Css NA 0.07422 mg/L PBTK NA 50% Rat Human +DTXSID60154659 Css NA 0.6917 mg/L PBTK NA 95% Rat Human +DTXSID60155121 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60155121 Fup 0.05581 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60155121 Vd NA 1.176 L/kg 1compartment NA NA Human Human +DTXSID60155121 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60155121 TK.Half.Life NA 4.804 hours 1compartment NA NA Human Human +DTXSID60155121 Css NA 0.4698 mg/L 3compartmentss NA 50% Human Human +DTXSID60155121 Css NA 3.775 mg/L 3compartmentss NA 95% Human Human +DTXSID60155121 Css NA 0.2968 mg/L PBTK NA 50% Human Human +DTXSID60155121 Css NA 2.318 mg/L PBTK NA 95% Human Human +DTXSID60155121 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60155121 Fup 0.05581 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60155121 Vd NA 0.8959 L/kg 1compartment NA NA Rat Human +DTXSID60155121 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60155121 TK.Half.Life NA 2.026 hours 1compartment NA NA Rat Human +DTXSID60155121 Css NA 0.02296 mg/L 3compartmentss NA 50% Rat Human +DTXSID60155121 Css NA 0.2038 mg/L 3compartmentss NA 95% Rat Human +DTXSID60155121 Css NA 0.01406 mg/L PBTK NA 50% Rat Human +DTXSID60155121 Css NA 0.1201 mg/L PBTK NA 95% Rat Human +DTXSID60155565 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60155565 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60155565 Vd NA 1.191 L/kg 1compartment NA NA Human Human +DTXSID60155565 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60155565 TK.Half.Life NA 7.984 hours 1compartment NA NA Human Human +DTXSID60155565 Css NA 0.4168 mg/L 3compartmentss NA 50% Human Human +DTXSID60155565 Css NA 2.992 mg/L 3compartmentss NA 95% Human Human +DTXSID60155565 Css NA 0.3827 mg/L PBTK NA 50% Human Human +DTXSID60155565 Css NA 2.014 mg/L PBTK NA 95% Human Human +DTXSID60155565 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60155565 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60155565 Vd NA 1.152 L/kg 1compartment NA NA Rat Human +DTXSID60155565 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60155565 TK.Half.Life NA 2.562 hours 1compartment NA NA Rat Human +DTXSID60155565 Css NA 0.002078 mg/L 3compartmentss NA 50% Rat Human +DTXSID60155565 Css NA 0.0152 mg/L 3compartmentss NA 95% Rat Human +DTXSID60155565 Css NA 0.001885 mg/L PBTK NA 50% Rat Human +DTXSID60155565 Css NA 0.01062 mg/L PBTK NA 95% Rat Human +DTXSID60161227 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60161227 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60161227 Vd NA 2.305 L/kg 1compartment NA NA Human Human +DTXSID60161227 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60161227 TK.Half.Life NA 10.17 hours 1compartment NA NA Human Human +DTXSID60161227 Css NA 0.4572 mg/L 3compartmentss NA 50% Human Human +DTXSID60161227 Css NA 3.581 mg/L 3compartmentss NA 95% Human Human +DTXSID60161227 Css NA 0.3882 mg/L PBTK NA 50% Human Human +DTXSID60161227 Css NA 2.563 mg/L PBTK NA 95% Human Human +DTXSID60161227 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60161227 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60161227 Vd NA 2.283 L/kg 1compartment NA NA Rat Human +DTXSID60161227 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60161227 TK.Half.Life NA 6.059 hours 1compartment NA NA Rat Human +DTXSID60161227 Css NA 0.05465 mg/L 3compartmentss NA 50% Rat Human +DTXSID60161227 Css NA 0.3449 mg/L 3compartmentss NA 95% Rat Human +DTXSID60161227 Css NA 0.04652 mg/L PBTK NA 50% Rat Human +DTXSID60161227 Css NA 0.2339 mg/L PBTK NA 95% Rat Human +DTXSID60162779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60162779 Fup 0.003 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60162779 Vd NA 0.4991 L/kg 1compartment NA NA Human Human +DTXSID60162779 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID60162779 TK.Half.Life NA 19.47 hours 1compartment NA NA Human Human +DTXSID60162779 Css NA 7.346 mg/L 3compartmentss NA 50% Human Human +DTXSID60162779 Css NA 62.39 mg/L 3compartmentss NA 95% Human Human +DTXSID60162779 Css NA 4.26 mg/L PBTK NA 50% Human Human +DTXSID60162779 Css NA 36.19 mg/L PBTK NA 95% Human Human DTXSID60162779 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID60162779 Fup 0.01 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID60162779 Vd NA 0.7893 L/kg 1compartment NA NA Rat Rat -DTXSID60162779 Days.Css NA 46 Days PBTK NA NA Rat Rat -DTXSID60162779 TK.Half.Life NA 179.1 hours 1compartment NA NA Rat Rat -DTXSID60162779 Css NA 34.52 mg/L 3compartmentss NA 50% Rat Rat -DTXSID60162779 Css NA 174.8 mg/L 3compartmentss NA 95% Rat Rat -DTXSID60162779 Css NA 19.14 mg/L PBTK NA 50% Rat Rat -DTXSID60162779 Css NA 94.87 mg/L PBTK NA 95% Rat Rat +DTXSID60162779 Vd NA 0.7439 L/kg 1compartment NA NA Rat Rat +DTXSID60162779 Days.Css NA 43 Days PBTK NA NA Rat Rat +DTXSID60162779 TK.Half.Life NA 168.1 hours 1compartment NA NA Rat Rat +DTXSID60162779 Css NA 7.296 mg/L 3compartmentss NA 50% Rat Rat +DTXSID60162779 Css NA 36.72 mg/L 3compartmentss NA 95% Rat Rat +DTXSID60162779 Css NA 4.382 mg/L PBTK NA 50% Rat Rat +DTXSID60162779 Css NA 22.05 mg/L PBTK NA 95% Rat Rat +DTXSID60165285 Clint 5.3 NA uL/min/million hepatocytes NA Yamagata 2017 NA Human Human +DTXSID60165285 Fup 0.08 NA NA Yamagata 2017 NA Human Human +DTXSID60165285 Vd NA 2.665 L/kg 1compartment NA NA Human Human +DTXSID60165285 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID60165285 TK.Half.Life NA 56.54 hours 1compartment NA NA Human Human +DTXSID60165285 Css NA 2.33 mg/L 3compartmentss NA 50% Human Human +DTXSID60165285 Css NA 12.53 mg/L 3compartmentss NA 95% Human Human +DTXSID60165285 Css NA 1.63 mg/L PBTK NA 50% Human Human +DTXSID60165285 Css NA 8.77 mg/L PBTK NA 95% Human Human +DTXSID60165285 Clint 5.3 NA uL/min/million hepatocytes NA Yamagata 2017 NA Rat Human +DTXSID60165285 Fup 0.08 NA NA Yamagata 2017 NA Rat Human +DTXSID60165285 Vd NA 2.004 L/kg 1compartment NA NA Rat Human +DTXSID60165285 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID60165285 TK.Half.Life NA 11.97 hours 1compartment NA NA Rat Human +DTXSID60165285 Css NA 0.07928 mg/L 3compartmentss NA 50% Rat Human +DTXSID60165285 Css NA 0.4818 mg/L 3compartmentss NA 95% Rat Human +DTXSID60165285 Css NA 0.05614 mg/L PBTK NA 50% Rat Human +DTXSID60165285 Css NA 0.3449 mg/L PBTK NA 95% Rat Human +DTXSID60166035 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60166035 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60166035 Vd NA 1.022 L/kg 1compartment NA NA Human Human +DTXSID60166035 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60166035 TK.Half.Life NA 3.666 hours 1compartment NA NA Human Human +DTXSID60166035 Css NA 0.2838 mg/L 3compartmentss NA 50% Human Human +DTXSID60166035 Css NA 1.713 mg/L 3compartmentss NA 95% Human Human +DTXSID60166035 Css NA 0.2192 mg/L PBTK NA 50% Human Human +DTXSID60166035 Css NA 1.19 mg/L PBTK NA 95% Human Human +DTXSID60166035 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60166035 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60166035 Vd NA 0.8672 L/kg 1compartment NA NA Rat Human +DTXSID60166035 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60166035 TK.Half.Life NA 1.74 hours 1compartment NA NA Rat Human +DTXSID60166035 Css NA 0.01262 mg/L 3compartmentss NA 50% Rat Human +DTXSID60166035 Css NA 0.09123 mg/L 3compartmentss NA 95% Rat Human +DTXSID60166035 Css NA 0.009804 mg/L PBTK NA 50% Rat Human +DTXSID60166035 Css NA 0.06199 mg/L PBTK NA 95% Rat Human +DTXSID60170955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60170955 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60170955 Vd NA 0.3943 L/kg 1compartment NA NA Human Human +DTXSID60170955 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60170955 TK.Half.Life NA 3.605 hours 1compartment NA NA Human Human +DTXSID60170955 Css NA 1.362 mg/L 3compartmentss NA 50% Human Human +DTXSID60170955 Css NA 13.25 mg/L 3compartmentss NA 95% Human Human +DTXSID60170955 Css NA 0.8022 mg/L PBTK NA 50% Human Human +DTXSID60170955 Css NA 7.665 mg/L PBTK NA 95% Human Human +DTXSID60170955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60170955 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60170955 Vd NA 0.3203 L/kg 1compartment NA NA Rat Human +DTXSID60170955 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60170955 TK.Half.Life NA 1.896 hours 1compartment NA NA Rat Human +DTXSID60170955 Css NA 0.06685 mg/L 3compartmentss NA 50% Rat Human +DTXSID60170955 Css NA 0.7199 mg/L 3compartmentss NA 95% Rat Human +DTXSID60170955 Css NA 0.03778 mg/L PBTK NA 50% Rat Human +DTXSID60170955 Css NA 0.4044 mg/L PBTK NA 95% Rat Human +DTXSID60177444 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60177444 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60177444 Vd NA 1.157 L/kg 1compartment NA NA Human Human +DTXSID60177444 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60177444 TK.Half.Life NA 9.361 hours 1compartment NA NA Human Human +DTXSID60177444 Css NA 0.4496 mg/L 3compartmentss NA 50% Human Human +DTXSID60177444 Css NA 3.08 mg/L 3compartmentss NA 95% Human Human +DTXSID60177444 Css NA 0.4476 mg/L PBTK NA 50% Human Human +DTXSID60177444 Css NA 2.131 mg/L PBTK NA 95% Human Human +DTXSID60177444 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60177444 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60177444 Vd NA 1.168 L/kg 1compartment NA NA Rat Human +DTXSID60177444 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60177444 TK.Half.Life NA 3.219 hours 1compartment NA NA Rat Human +DTXSID60177444 Css NA 0.002286 mg/L 3compartmentss NA 50% Rat Human +DTXSID60177444 Css NA 0.01672 mg/L 3compartmentss NA 95% Rat Human +DTXSID60177444 Css NA 0.002234 mg/L PBTK NA 50% Rat Human +DTXSID60177444 Css NA 0.01123 mg/L PBTK NA 95% Rat Human +DTXSID60180332 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60180332 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60180332 Vd NA 3.204 L/kg 1compartment NA NA Human Human +DTXSID60180332 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60180332 TK.Half.Life NA 8.716 hours 1compartment NA NA Human Human +DTXSID60180332 Css NA 0.174 mg/L 3compartmentss NA 50% Human Human +DTXSID60180332 Css NA 1.274 mg/L 3compartmentss NA 95% Human Human +DTXSID60180332 Css NA 0.1888 mg/L PBTK NA 50% Human Human +DTXSID60180332 Css NA 1.135 mg/L PBTK NA 95% Human Human +DTXSID60180332 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60180332 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60180332 Vd NA 3.226 L/kg 1compartment NA NA Rat Human +DTXSID60180332 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60180332 TK.Half.Life NA 5.2 hours 1compartment NA NA Rat Human +DTXSID60180332 Css NA 0.01816 mg/L 3compartmentss NA 50% Rat Human +DTXSID60180332 Css NA 0.0999 mg/L 3compartmentss NA 95% Rat Human +DTXSID60180332 Css NA 0.02054 mg/L PBTK NA 50% Rat Human +DTXSID60180332 Css NA 0.08557 mg/L PBTK NA 95% Rat Human +DTXSID60184390 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60184390 Fup 0.36 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60184390 Vd NA 3.802 L/kg 1compartment NA NA Human Human +DTXSID60184390 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60184390 TK.Half.Life NA 3.139 hours 1compartment NA NA Human Human +DTXSID60184390 Css NA 0.02849 mg/L 3compartmentss NA 50% Human Human +DTXSID60184390 Css NA 0.2766 mg/L 3compartmentss NA 95% Human Human +DTXSID60184390 Css NA 0.03584 mg/L PBTK NA 50% Human Human +DTXSID60184390 Css NA 0.2702 mg/L PBTK NA 95% Human Human +DTXSID60184390 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60184390 Fup 0.36 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60184390 Vd NA 3.865 L/kg 1compartment NA NA Rat Human +DTXSID60184390 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60184390 TK.Half.Life NA 1.753 hours 1compartment NA NA Rat Human +DTXSID60184390 Css NA 0.003397 mg/L 3compartmentss NA 50% Rat Human +DTXSID60184390 Css NA 0.02637 mg/L 3compartmentss NA 95% Rat Human +DTXSID60184390 Css NA 0.004451 mg/L PBTK NA 50% Rat Human +DTXSID60184390 Css NA 0.02419 mg/L PBTK NA 95% Rat Human +DTXSID60186273 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60186273 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60186273 Vd NA 3.049 L/kg 1compartment NA NA Human Human +DTXSID60186273 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60186273 TK.Half.Life NA 9.698 hours 1compartment NA NA Human Human +DTXSID60186273 Css NA 0.2015 mg/L 3compartmentss NA 50% Human Human +DTXSID60186273 Css NA 1.32 mg/L 3compartmentss NA 95% Human Human +DTXSID60186273 Css NA 0.2 mg/L PBTK NA 50% Human Human +DTXSID60186273 Css NA 1.111 mg/L PBTK NA 95% Human Human +DTXSID60186273 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60186273 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60186273 Vd NA 2.954 L/kg 1compartment NA NA Rat Human +DTXSID60186273 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60186273 TK.Half.Life NA 5.138 hours 1compartment NA NA Rat Human +DTXSID60186273 Css NA 0.008834 mg/L 3compartmentss NA 50% Rat Human +DTXSID60186273 Css NA 0.07011 mg/L 3compartmentss NA 95% Rat Human +DTXSID60186273 Css NA 0.009123 mg/L PBTK NA 50% Rat Human +DTXSID60186273 Css NA 0.05769 mg/L PBTK NA 95% Rat Human +DTXSID60190198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60190198 Fup 0.0163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60190198 Vd NA 3.059 L/kg 1compartment NA NA Human Human +DTXSID60190198 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID60190198 TK.Half.Life NA 74.93 hours 1compartment NA NA Human Human +DTXSID60190198 Css NA 2.992 mg/L 3compartmentss NA 50% Human Human +DTXSID60190198 Css NA 19.81 mg/L 3compartmentss NA 95% Human Human +DTXSID60190198 Css NA 2.054 mg/L PBTK NA 50% Human Human +DTXSID60190198 Css NA 13.12 mg/L PBTK NA 95% Human Human +DTXSID60190198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60190198 Fup 0.0163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60190198 Vd NA 2.291 L/kg 1compartment NA NA Rat Human +DTXSID60190198 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID60190198 TK.Half.Life NA 11 hours 1compartment NA NA Rat Human +DTXSID60190198 Css NA 0.3853 mg/L 3compartmentss NA 50% Rat Human +DTXSID60190198 Css NA 2.22 mg/L 3compartmentss NA 95% Rat Human +DTXSID60190198 Css NA 0.2623 mg/L PBTK NA 50% Rat Human +DTXSID60190198 Css NA 1.452 mg/L PBTK NA 95% Rat Human DTXSID60194378 Clint 0.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID60194378 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID60194378 Vd NA 0.2401 L/kg 1compartment NA NA Human Human +DTXSID60194378 Vd NA 0.2406 L/kg 1compartment NA NA Human Human DTXSID60194378 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID60194378 TK.Half.Life NA 12.04 hours 1compartment NA NA Human Human -DTXSID60194378 Css NA 8.304 mg/L 3compartmentss NA 50% Human Human -DTXSID60194378 Css NA 40.98 mg/L 3compartmentss NA 95% Human Human -DTXSID60194378 Css NA 5.01 mg/L PBTK NA 50% Human Human -DTXSID60194378 Css NA 23.86 mg/L PBTK NA 95% Human Human +DTXSID60194378 TK.Half.Life NA 12.07 hours 1compartment NA NA Human Human +DTXSID60194378 Css NA 7.15 mg/L 3compartmentss NA 50% Human Human +DTXSID60194378 Css NA 35.25 mg/L 3compartmentss NA 95% Human Human +DTXSID60194378 Css NA 4.302 mg/L PBTK NA 50% Human Human +DTXSID60194378 Css NA 20.44 mg/L PBTK NA 95% Human Human DTXSID60194378 Clint 0.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID60194378 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID60194378 Vd NA 0.233 L/kg 1compartment NA NA Rat Human +DTXSID60194378 Vd NA 0.2334 L/kg 1compartment NA NA Rat Human DTXSID60194378 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID60194378 TK.Half.Life NA 5.484 hours 1compartment NA NA Rat Human -DTXSID60194378 Css NA 3.314 mg/L 3compartmentss NA 50% Rat Human -DTXSID60194378 Css NA 13.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID60194378 Css NA 1.86 mg/L PBTK NA 50% Rat Human -DTXSID60194378 Css NA 7.189 mg/L PBTK NA 95% Rat Human -DTXSID6020014 Clint NA 0.007402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020014 Fup NA 0.6372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020014 Vd NA 0.7135 L/kg 1compartment NA NA Human Human -DTXSID6020014 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020014 TK.Half.Life NA 7.155 hours 1compartment NA NA Human Human -DTXSID6020014 Css NA 1.095 mg/L 3compartmentss NA 50% Human Human -DTXSID6020014 Css NA 7.696 mg/L 3compartmentss NA 95% Human Human -DTXSID6020014 Css NA 0.9193 mg/L PBTK NA 50% Human Human -DTXSID6020014 Css NA 4.941 mg/L PBTK NA 95% Human Human -DTXSID6020014 Clint NA 0.007402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020014 Fup NA 0.6372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020014 Vd NA 0.7251 L/kg 1compartment NA NA Rat Human +DTXSID60194378 TK.Half.Life NA 5.497 hours 1compartment NA NA Rat Human +DTXSID60194378 Css NA 0.2423 mg/L 3compartmentss NA 50% Rat Human +DTXSID60194378 Css NA 1.584 mg/L 3compartmentss NA 95% Rat Human +DTXSID60194378 Css NA 0.139 mg/L PBTK NA 50% Rat Human +DTXSID60194378 Css NA 0.8923 mg/L PBTK NA 95% Rat Human +DTXSID6020014 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020014 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020014 Vd NA 0.5061 L/kg 1compartment NA NA Human Human +DTXSID6020014 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6020014 TK.Half.Life NA 12.92 hours 1compartment NA NA Human Human +DTXSID6020014 Css NA 2.935 mg/L 3compartmentss NA 50% Human Human +DTXSID6020014 Css NA 11.13 mg/L 3compartmentss NA 95% Human Human +DTXSID6020014 Css NA 2.02 mg/L PBTK NA 50% Human Human +DTXSID6020014 Css NA 6.972 mg/L PBTK NA 95% Human Human +DTXSID6020014 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020014 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020014 Vd NA 0.4912 L/kg 1compartment NA NA Rat Human DTXSID6020014 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020014 TK.Half.Life NA 2.494 hours 1compartment NA NA Rat Human -DTXSID6020014 Css NA 0.294 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020014 Css NA 1.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020014 Css NA 0.2362 mg/L PBTK NA 50% Rat Human -DTXSID6020014 Css NA 1.13 mg/L PBTK NA 95% Rat Human -DTXSID6020062 Clint NA 0.4655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020062 Fup NA 0.6191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020062 Vd NA 1.163 L/kg 1compartment NA NA Human Human +DTXSID6020014 TK.Half.Life NA 4.255 hours 1compartment NA NA Rat Human +DTXSID6020014 Css NA 0.1905 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020014 Css NA 0.6115 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020014 Css NA 0.1288 mg/L PBTK NA 50% Rat Human +DTXSID6020014 Css NA 0.3671 mg/L PBTK NA 95% Rat Human +DTXSID6020062 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020062 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020062 Vd NA 0.684 L/kg 1compartment NA NA Human Human DTXSID6020062 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020062 TK.Half.Life NA 7.457 hours 1compartment NA NA Human Human -DTXSID6020062 Css NA 0.6515 mg/L 3compartmentss NA 50% Human Human -DTXSID6020062 Css NA 4.645 mg/L 3compartmentss NA 95% Human Human -DTXSID6020062 Css NA 0.5574 mg/L PBTK NA 50% Human Human -DTXSID6020062 Css NA 2.981 mg/L PBTK NA 95% Human Human -DTXSID6020062 Clint NA 0.4655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020062 Fup NA 0.6191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020062 Vd NA 1.055 L/kg 1compartment NA NA Rat Human +DTXSID6020062 TK.Half.Life NA 1.031 hours 1compartment NA NA Human Human +DTXSID6020062 Css NA 0.09098 mg/L 3compartmentss NA 50% Human Human +DTXSID6020062 Css NA 0.6377 mg/L 3compartmentss NA 95% Human Human +DTXSID6020062 Css NA 0.06346 mg/L PBTK NA 50% Human Human +DTXSID6020062 Css NA 0.4197 mg/L PBTK NA 95% Human Human +DTXSID6020062 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020062 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020062 Vd NA 0.6139 L/kg 1compartment NA NA Rat Human DTXSID6020062 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020062 TK.Half.Life NA 2.788 hours 1compartment NA NA Rat Human -DTXSID6020062 Css NA 0.2277 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020062 Css NA 1.509 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020062 Css NA 0.188 mg/L PBTK NA 50% Rat Human -DTXSID6020062 Css NA 0.9103 mg/L PBTK NA 95% Rat Human -DTXSID6020064 Clint NA 2.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020064 Fup NA 0.4003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020064 Vd NA 0.6719 L/kg 1compartment NA NA Human Human +DTXSID6020062 TK.Half.Life NA 0.4997 hours 1compartment NA NA Rat Human +DTXSID6020062 Css NA 0.01146 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020062 Css NA 0.06272 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020062 Css NA 0.007898 mg/L PBTK NA 50% Rat Human +DTXSID6020062 Css NA 0.04064 mg/L PBTK NA 95% Rat Human +DTXSID6020064 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020064 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020064 Vd NA 0.6835 L/kg 1compartment NA NA Human Human DTXSID6020064 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020064 TK.Half.Life NA 2.343 hours 1compartment NA NA Human Human -DTXSID6020064 Css NA 0.3489 mg/L 3compartmentss NA 50% Human Human -DTXSID6020064 Css NA 1.961 mg/L 3compartmentss NA 95% Human Human -DTXSID6020064 Css NA 0.2592 mg/L PBTK NA 50% Human Human -DTXSID6020064 Css NA 1.259 mg/L PBTK NA 95% Human Human -DTXSID6020064 Clint NA 2.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020064 Fup NA 0.4003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020064 Vd NA 0.6345 L/kg 1compartment NA NA Rat Human +DTXSID6020064 TK.Half.Life NA 0.8684 hours 1compartment NA NA Human Human +DTXSID6020064 Css NA 0.06299 mg/L 3compartmentss NA 50% Human Human +DTXSID6020064 Css NA 0.4968 mg/L 3compartmentss NA 95% Human Human +DTXSID6020064 Css NA 0.04558 mg/L PBTK NA 50% Human Human +DTXSID6020064 Css NA 0.3242 mg/L PBTK NA 95% Human Human +DTXSID6020064 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020064 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020064 Vd NA 0.6377 L/kg 1compartment NA NA Rat Human DTXSID6020064 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020064 TK.Half.Life NA 1.199 hours 1compartment NA NA Rat Human -DTXSID6020064 Css NA 0.1618 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020064 Css NA 0.7237 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020064 Css NA 0.1152 mg/L PBTK NA 50% Rat Human -DTXSID6020064 Css NA 0.4328 mg/L PBTK NA 95% Rat Human -DTXSID6020066 Clint NA 5.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020066 Fup NA 0.9416 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020066 Vd NA 1.219 L/kg 1compartment NA NA Human Human +DTXSID6020064 TK.Half.Life NA 0.4258 hours 1compartment NA NA Rat Human +DTXSID6020064 Css NA 0.008033 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020064 Css NA 0.04749 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020064 Css NA 0.005783 mg/L PBTK NA 50% Rat Human +DTXSID6020064 Css NA 0.03175 mg/L PBTK NA 95% Rat Human +DTXSID6020066 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020066 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020066 Vd NA 0.751 L/kg 1compartment NA NA Human Human DTXSID6020066 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020066 TK.Half.Life NA 1.443 hours 1compartment NA NA Human Human -DTXSID6020066 Css NA 0.08986 mg/L 3compartmentss NA 50% Human Human -DTXSID6020066 Css NA 0.5159 mg/L 3compartmentss NA 95% Human Human -DTXSID6020066 Css NA 0.08008 mg/L PBTK NA 50% Human Human -DTXSID6020066 Css NA 0.408 mg/L PBTK NA 95% Human Human -DTXSID6020066 Clint NA 5.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020066 Fup NA 0.9416 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020066 Vd NA 1.163 L/kg 1compartment NA NA Rat Human +DTXSID6020066 TK.Half.Life NA 0.8183 hours 1compartment NA NA Human Human +DTXSID6020066 Css NA 0.04578 mg/L 3compartmentss NA 50% Human Human +DTXSID6020066 Css NA 0.379 mg/L 3compartmentss NA 95% Human Human +DTXSID6020066 Css NA 0.03489 mg/L PBTK NA 50% Human Human +DTXSID6020066 Css NA 0.2597 mg/L PBTK NA 95% Human Human +DTXSID6020066 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020066 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020066 Vd NA 0.712 L/kg 1compartment NA NA Rat Human DTXSID6020066 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020066 TK.Half.Life NA 0.7127 hours 1compartment NA NA Rat Human -DTXSID6020066 Css NA 0.04148 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020066 Css NA 0.1835 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020066 Css NA 0.03754 mg/L PBTK NA 50% Rat Human -DTXSID6020066 Css NA 0.1376 mg/L PBTK NA 95% Rat Human +DTXSID6020066 TK.Half.Life NA 0.397 hours 1compartment NA NA Rat Human +DTXSID6020066 Css NA 0.005692 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020066 Css NA 0.03526 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020066 Css NA 0.004338 mg/L PBTK NA 50% Rat Human +DTXSID6020066 Css NA 0.02379 mg/L PBTK NA 95% Rat Human DTXSID6020068 Clint 30.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020068 Fup 0.0305 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020068 Vd NA 1.536 L/kg 1compartment NA NA Human Human DTXSID6020068 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6020068 TK.Half.Life NA 7.817 hours 1compartment NA NA Human Human -DTXSID6020068 Css NA 0.551 mg/L 3compartmentss NA 50% Human Human -DTXSID6020068 Css NA 3.962 mg/L 3compartmentss NA 95% Human Human -DTXSID6020068 Css NA 0.3563 mg/L PBTK NA 50% Human Human -DTXSID6020068 Css NA 2.445 mg/L PBTK NA 95% Human Human +DTXSID6020068 Css NA 0.532 mg/L 3compartmentss NA 50% Human Human +DTXSID6020068 Css NA 3.879 mg/L 3compartmentss NA 95% Human Human +DTXSID6020068 Css NA 0.3415 mg/L PBTK NA 50% Human Human +DTXSID6020068 Css NA 2.376 mg/L PBTK NA 95% Human Human DTXSID6020068 Clint 30.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6020068 Fup 0.0305 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6020068 Vd NA 1.145 L/kg 1compartment NA NA Rat Human DTXSID6020068 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6020068 TK.Half.Life NA 2.97 hours 1compartment NA NA Rat Human -DTXSID6020068 Css NA 0.3103 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020068 Css NA 1.755 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020068 Css NA 0.1882 mg/L PBTK NA 50% Rat Human -DTXSID6020068 Css NA 1.019 mg/L PBTK NA 95% Rat Human -DTXSID6020141 Clint NA 3.782 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020141 Fup NA 0.2739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020141 Vd NA 2.159 L/kg 1compartment NA NA Human Human -DTXSID6020141 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6020141 TK.Half.Life NA 13.02 hours 1compartment NA NA Human Human -DTXSID6020141 Css NA 0.636 mg/L 3compartmentss NA 50% Human Human -DTXSID6020141 Css NA 3.111 mg/L 3compartmentss NA 95% Human Human -DTXSID6020141 Css NA 0.4774 mg/L PBTK NA 50% Human Human -DTXSID6020141 Css NA 2.155 mg/L PBTK NA 95% Human Human -DTXSID6020141 Clint NA 3.782 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020141 Fup NA 0.2739 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020141 Vd NA 1.676 L/kg 1compartment NA NA Rat Human +DTXSID6020068 Css NA 0.06905 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020068 Css NA 0.4129 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020068 Css NA 0.0434 mg/L PBTK NA 50% Rat Human +DTXSID6020068 Css NA 0.2528 mg/L PBTK NA 95% Rat Human +DTXSID6020141 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020141 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020141 Vd NA 1.674 L/kg 1compartment NA NA Human Human +DTXSID6020141 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6020141 TK.Half.Life NA 3.918 hours 1compartment NA NA Human Human +DTXSID6020141 Css NA 0.2199 mg/L 3compartmentss NA 50% Human Human +DTXSID6020141 Css NA 1.619 mg/L 3compartmentss NA 95% Human Human +DTXSID6020141 Css NA 0.1507 mg/L PBTK NA 50% Human Human +DTXSID6020141 Css NA 1.034 mg/L PBTK NA 95% Human Human +DTXSID6020141 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020141 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020141 Vd NA 1.289 L/kg 1compartment NA NA Rat Human DTXSID6020141 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020141 TK.Half.Life NA 3.934 hours 1compartment NA NA Rat Human -DTXSID6020141 Css NA 0.3134 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020141 Css NA 1.074 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020141 Css NA 0.228 mg/L PBTK NA 50% Rat Human -DTXSID6020141 Css NA 0.7011 mg/L PBTK NA 95% Rat Human -DTXSID6020143 Clint NA 0.03393 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020143 Fup NA 0.1766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020143 Vd NA 0.3792 L/kg 1compartment NA NA Human Human -DTXSID6020143 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6020143 TK.Half.Life NA 13.16 hours 1compartment NA NA Human Human -DTXSID6020143 Css NA 4.26 mg/L 3compartmentss NA 50% Human Human -DTXSID6020143 Css NA 16.23 mg/L 3compartmentss NA 95% Human Human -DTXSID6020143 Css NA 2.838 mg/L PBTK NA 50% Human Human -DTXSID6020143 Css NA 9.924 mg/L PBTK NA 95% Human Human +DTXSID6020141 TK.Half.Life NA 1.455 hours 1compartment NA NA Rat Human +DTXSID6020141 Css NA 0.02822 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020141 Css NA 0.1604 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020141 Css NA 0.01904 mg/L PBTK NA 50% Rat Human +DTXSID6020141 Css NA 0.1026 mg/L PBTK NA 95% Rat Human +DTXSID6020143 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020143 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020143 Vd NA 0.4978 L/kg 1compartment NA NA Human Human +DTXSID6020143 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6020143 TK.Half.Life NA 0.6418 hours 1compartment NA NA Human Human +DTXSID6020143 Css NA 0.0657 mg/L 3compartmentss NA 50% Human Human +DTXSID6020143 Css NA 0.5004 mg/L 3compartmentss NA 95% Human Human +DTXSID6020143 Css NA 0.04757 mg/L PBTK NA 50% Human Human +DTXSID6020143 Css NA 0.3386 mg/L PBTK NA 95% Human Human DTXSID6020143 Clint 0.78 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID6020143 Fup 0.422 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID6020143 Vd NA 0.5971 L/kg 1compartment NA NA Rat Rat DTXSID6020143 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID6020143 TK.Half.Life NA 1.944 hours 1compartment NA NA Rat Rat -DTXSID6020143 Css NA 0.2716 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6020143 Css NA 1.169 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6020143 Css NA 0.2059 mg/L PBTK NA 50% Rat Rat -DTXSID6020143 Css NA 0.7047 mg/L PBTK NA 95% Rat Rat -DTXSID6020145 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020145 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020145 Vd NA 0.9998 L/kg 1compartment NA NA Human Human -DTXSID6020145 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020145 TK.Half.Life NA 6.545 hours 1compartment NA NA Human Human -DTXSID6020145 Css NA 0.7866 mg/L 3compartmentss NA 50% Human Human -DTXSID6020145 Css NA 5.739 mg/L 3compartmentss NA 95% Human Human -DTXSID6020145 Css NA 0.6994 mg/L PBTK NA 50% Human Human -DTXSID6020145 Css NA 3.81 mg/L PBTK NA 95% Human Human -DTXSID6020145 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020145 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020145 Vd NA 1.002 L/kg 1compartment NA NA Rat Human -DTXSID6020145 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020145 TK.Half.Life NA 2.215 hours 1compartment NA NA Rat Human -DTXSID6020145 Css NA 0.1968 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020145 Css NA 1.279 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020145 Css NA 0.1727 mg/L PBTK NA 50% Rat Human -DTXSID6020145 Css NA 0.7852 mg/L PBTK NA 95% Rat Human +DTXSID6020143 Css NA 0.06013 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6020143 Css NA 0.263 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6020143 Css NA 0.04734 mg/L PBTK NA 50% Rat Rat +DTXSID6020143 Css NA 0.1657 mg/L PBTK NA 95% Rat Rat DTXSID6020147 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020147 Fup 0.287 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020147 Vd NA 0.8213 L/kg 1compartment NA NA Human Human DTXSID6020147 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID6020147 TK.Half.Life NA 19.45 hours 1compartment NA NA Human Human -DTXSID6020147 Css NA 2.562 mg/L 3compartmentss NA 50% Human Human -DTXSID6020147 Css NA 8.241 mg/L 3compartmentss NA 95% Human Human -DTXSID6020147 Css NA 1.874 mg/L PBTK NA 50% Human Human -DTXSID6020147 Css NA 5.37 mg/L PBTK NA 95% Human Human +DTXSID6020147 Css NA 2.514 mg/L 3compartmentss NA 50% Human Human +DTXSID6020147 Css NA 8.091 mg/L 3compartmentss NA 95% Human Human +DTXSID6020147 Css NA 1.829 mg/L PBTK NA 50% Human Human +DTXSID6020147 Css NA 5.305 mg/L PBTK NA 95% Human Human DTXSID6020147 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6020147 Fup 0.287 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6020147 Vd NA 0.7232 L/kg 1compartment NA NA Rat Human DTXSID6020147 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6020147 TK.Half.Life NA 5.622 hours 1compartment NA NA Rat Human -DTXSID6020147 Css NA 0.701 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020147 Css NA 1.904 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020147 Css NA 0.4893 mg/L PBTK NA 50% Rat Human -DTXSID6020147 Css NA 1.156 mg/L PBTK NA 95% Rat Human -DTXSID6020149 Clint NA 14.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020149 Fup NA 0.9534 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020149 Vd NA 0.9676 L/kg 1compartment NA NA Human Human +DTXSID6020147 Css NA 0.1601 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020147 Css NA 0.4182 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020147 Css NA 0.1156 mg/L PBTK NA 50% Rat Human +DTXSID6020147 Css NA 0.2637 mg/L PBTK NA 95% Rat Human +DTXSID6020149 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020149 Fup 0.582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020149 Vd NA 0.7175 L/kg 1compartment NA NA Human Human DTXSID6020149 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020149 TK.Half.Life NA 0.7523 hours 1compartment NA NA Human Human -DTXSID6020149 Css NA 0.03485 mg/L 3compartmentss NA 50% Human Human -DTXSID6020149 Css NA 0.2452 mg/L 3compartmentss NA 95% Human Human -DTXSID6020149 Css NA 0.03012 mg/L PBTK NA 50% Human Human -DTXSID6020149 Css NA 0.1878 mg/L PBTK NA 95% Human Human -DTXSID6020149 Clint NA 14.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020149 Fup NA 0.9534 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020149 Vd NA 0.9705 L/kg 1compartment NA NA Rat Human +DTXSID6020149 TK.Half.Life NA 8.028 hours 1compartment NA NA Human Human +DTXSID6020149 Css NA 1.223 mg/L 3compartmentss NA 50% Human Human +DTXSID6020149 Css NA 8.726 mg/L 3compartmentss NA 95% Human Human +DTXSID6020149 Css NA 0.9794 mg/L PBTK NA 50% Human Human +DTXSID6020149 Css NA 5.441 mg/L PBTK NA 95% Human Human +DTXSID6020149 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020149 Fup 0.582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020149 Vd NA 0.7176 L/kg 1compartment NA NA Rat Human DTXSID6020149 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020149 TK.Half.Life NA 0.3727 hours 1compartment NA NA Rat Human -DTXSID6020149 Css NA 0.01765 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020149 Css NA 0.09261 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020149 Css NA 0.01508 mg/L PBTK NA 50% Rat Human -DTXSID6020149 Css NA 0.07258 mg/L PBTK NA 95% Rat Human -DTXSID6020193 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020193 Fup NA 0.4784 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020193 Vd NA 1.383 L/kg 1compartment NA NA Human Human +DTXSID6020149 TK.Half.Life NA 2.722 hours 1compartment NA NA Rat Human +DTXSID6020149 Css NA 0.07497 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020149 Css NA 0.4785 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020149 Css NA 0.05965 mg/L PBTK NA 50% Rat Human +DTXSID6020149 Css NA 0.2898 mg/L PBTK NA 95% Rat Human +DTXSID6020193 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020193 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020193 Vd NA 1.318 L/kg 1compartment NA NA Human Human DTXSID6020193 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6020193 TK.Half.Life NA 21.87 hours 1compartment NA NA Human Human -DTXSID6020193 Css NA 1.62 mg/L 3compartmentss NA 50% Human Human -DTXSID6020193 Css NA 7.61 mg/L 3compartmentss NA 95% Human Human -DTXSID6020193 Css NA 1.334 mg/L PBTK NA 50% Human Human -DTXSID6020193 Css NA 5.077 mg/L PBTK NA 95% Human Human -DTXSID6020193 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020193 Fup NA 0.4784 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020193 Vd NA 1.184 L/kg 1compartment NA NA Rat Human +DTXSID6020193 TK.Half.Life NA 22.15 hours 1compartment NA NA Human Human +DTXSID6020193 Css NA 1.662 mg/L 3compartmentss NA 50% Human Human +DTXSID6020193 Css NA 7.589 mg/L 3compartmentss NA 95% Human Human +DTXSID6020193 Css NA 1.357 mg/L PBTK NA 50% Human Human +DTXSID6020193 Css NA 5.012 mg/L PBTK NA 95% Human Human +DTXSID6020193 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020193 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020193 Vd NA 1.123 L/kg 1compartment NA NA Rat Human DTXSID6020193 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020193 TK.Half.Life NA 5.677 hours 1compartment NA NA Rat Human -DTXSID6020193 Css NA 0.433 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020193 Css NA 1.783 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020193 Css NA 0.3465 mg/L PBTK NA 50% Rat Human -DTXSID6020193 Css NA 1.108 mg/L PBTK NA 95% Rat Human +DTXSID6020193 TK.Half.Life NA 5.762 hours 1compartment NA NA Rat Human +DTXSID6020193 Css NA 0.1051 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020193 Css NA 0.4172 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020193 Css NA 0.08542 mg/L PBTK NA 50% Rat Human +DTXSID6020193 Css NA 0.2671 mg/L PBTK NA 95% Rat Human DTXSID6020197 Clint 178 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020197 Fup 0.00955 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6020197 Vd NA 0.4605 L/kg 1compartment NA NA Human Human +DTXSID6020197 Vd NA 0.185 L/kg 1compartment NA NA Human Human DTXSID6020197 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020197 TK.Half.Life NA 1.37 hours 1compartment NA NA Human Human -DTXSID6020197 Css NA 0.2376 mg/L 3compartmentss NA 50% Human Human -DTXSID6020197 Css NA 1.818 mg/L 3compartmentss NA 95% Human Human -DTXSID6020197 Css NA 0.1412 mg/L PBTK NA 50% Human Human -DTXSID6020197 Css NA 1.069 mg/L PBTK NA 95% Human Human +DTXSID6020197 TK.Half.Life NA 0.6001 hours 1compartment NA NA Human Human +DTXSID6020197 Css NA 0.2254 mg/L 3compartmentss NA 50% Human Human +DTXSID6020197 Css NA 1.825 mg/L 3compartmentss NA 95% Human Human +DTXSID6020197 Css NA 0.1317 mg/L PBTK NA 50% Human Human +DTXSID6020197 Css NA 1.061 mg/L PBTK NA 95% Human Human DTXSID6020197 Clint 178 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6020197 Fup 0.00955 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6020197 Vd NA 0.3561 L/kg 1compartment NA NA Rat Human +DTXSID6020197 Vd NA 0.1792 L/kg 1compartment NA NA Rat Human DTXSID6020197 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020197 TK.Half.Life NA 0.6383 hours 1compartment NA NA Rat Human -DTXSID6020197 Css NA 0.1377 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020197 Css NA 0.8982 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020197 Css NA 0.07638 mg/L PBTK NA 50% Rat Human -DTXSID6020197 Css NA 0.4941 mg/L PBTK NA 95% Rat Human -DTXSID6020220 Clint NA 11.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020220 Fup NA 0.2078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020220 Vd NA 2.697 L/kg 1compartment NA NA Human Human -DTXSID6020220 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6020220 TK.Half.Life NA 14.56 hours 1compartment NA NA Human Human -DTXSID6020220 Css NA 0.5696 mg/L 3compartmentss NA 50% Human Human -DTXSID6020220 Css NA 3.177 mg/L 3compartmentss NA 95% Human Human -DTXSID6020220 Css NA 0.4089 mg/L PBTK NA 50% Human Human -DTXSID6020220 Css NA 2.194 mg/L PBTK NA 95% Human Human -DTXSID6020220 Clint NA 11.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020220 Fup NA 0.2078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020220 Vd NA 2.047 L/kg 1compartment NA NA Rat Human +DTXSID6020197 TK.Half.Life NA 0.3605 hours 1compartment NA NA Rat Human +DTXSID6020197 Css NA 0.01168 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020197 Css NA 0.1061 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020197 Css NA 0.006465 mg/L PBTK NA 50% Rat Human +DTXSID6020197 Css NA 0.0593 mg/L PBTK NA 95% Rat Human +DTXSID6020220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020220 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020220 Vd NA 1.032 L/kg 1compartment NA NA Human Human +DTXSID6020220 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6020220 TK.Half.Life NA 1.449 hours 1compartment NA NA Human Human +DTXSID6020220 Css NA 0.07867 mg/L 3compartmentss NA 50% Human Human +DTXSID6020220 Css NA 0.5765 mg/L 3compartmentss NA 95% Human Human +DTXSID6020220 Css NA 0.05707 mg/L PBTK NA 50% Human Human +DTXSID6020220 Css NA 0.3917 mg/L PBTK NA 95% Human Human +DTXSID6020220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020220 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020220 Vd NA 0.871 L/kg 1compartment NA NA Rat Human DTXSID6020220 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020220 TK.Half.Life NA 3.357 hours 1compartment NA NA Rat Human -DTXSID6020220 Css NA 0.3021 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020220 Css NA 1.302 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020220 Css NA 0.2103 mg/L PBTK NA 50% Rat Human -DTXSID6020220 Css NA 0.8575 mg/L PBTK NA 95% Rat Human -DTXSID6020222 Clint NA 0.1926 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020222 Fup NA 0.9042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020222 Vd NA 1.012 L/kg 1compartment NA NA Human Human +DTXSID6020220 TK.Half.Life NA 0.6371 hours 1compartment NA NA Rat Human +DTXSID6020220 Css NA 0.009894 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020220 Css NA 0.05336 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020220 Css NA 0.007196 mg/L PBTK NA 50% Rat Human +DTXSID6020220 Css NA 0.03616 mg/L PBTK NA 95% Rat Human +DTXSID6020222 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020222 Fup 0.751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020222 Vd NA 0.9031 L/kg 1compartment NA NA Human Human DTXSID6020222 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020222 TK.Half.Life NA 5.613 hours 1compartment NA NA Human Human -DTXSID6020222 Css NA 0.624 mg/L 3compartmentss NA 50% Human Human -DTXSID6020222 Css NA 2.522 mg/L 3compartmentss NA 95% Human Human -DTXSID6020222 Css NA 0.5499 mg/L PBTK NA 50% Human Human -DTXSID6020222 Css NA 1.787 mg/L PBTK NA 95% Human Human -DTXSID6020222 Clint NA 0.1926 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020222 Fup NA 0.9042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020222 Vd NA 1.001 L/kg 1compartment NA NA Rat Human +DTXSID6020222 TK.Half.Life NA 7.889 hours 1compartment NA NA Human Human +DTXSID6020222 Css NA 0.8487 mg/L 3compartmentss NA 50% Human Human +DTXSID6020222 Css NA 5.49 mg/L 3compartmentss NA 95% Human Human +DTXSID6020222 Css NA 0.7235 mg/L PBTK NA 50% Human Human +DTXSID6020222 Css NA 3.517 mg/L PBTK NA 95% Human Human +DTXSID6020222 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020222 Fup 0.751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020222 Vd NA 0.8917 L/kg 1compartment NA NA Rat Human DTXSID6020222 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020222 TK.Half.Life NA 2.125 hours 1compartment NA NA Rat Human -DTXSID6020222 Css NA 0.1851 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020222 Css NA 0.6767 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020222 Css NA 0.1608 mg/L PBTK NA 50% Rat Human -DTXSID6020222 Css NA 0.4451 mg/L PBTK NA 95% Rat Human +DTXSID6020222 TK.Half.Life NA 2.627 hours 1compartment NA NA Rat Human +DTXSID6020222 Css NA 0.01603 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020222 Css NA 0.1345 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020222 Css NA 0.01311 mg/L PBTK NA 50% Rat Human +DTXSID6020222 Css NA 0.08777 mg/L PBTK NA 95% Rat Human DTXSID6020224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6020224 Fup NA 0.7972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6020224 Vd NA 0.7235 L/kg 1compartment NA NA Human Human DTXSID6020224 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6020224 TK.Half.Life NA 5.879 hours 1compartment NA NA Human Human -DTXSID6020224 Css NA 0.9986 mg/L 3compartmentss NA 50% Human Human -DTXSID6020224 Css NA 5.875 mg/L 3compartmentss NA 95% Human Human -DTXSID6020224 Css NA 0.8179 mg/L PBTK NA 50% Human Human -DTXSID6020224 Css NA 3.808 mg/L PBTK NA 95% Human Human +DTXSID6020224 Css NA 0.8492 mg/L 3compartmentss NA 50% Human Human +DTXSID6020224 Css NA 5.149 mg/L 3compartmentss NA 95% Human Human +DTXSID6020224 Css NA 0.701 mg/L PBTK NA 50% Human Human +DTXSID6020224 Css NA 3.33 mg/L PBTK NA 95% Human Human DTXSID6020224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6020224 Fup NA 0.7972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6020224 Vd NA 0.7494 L/kg 1compartment NA NA Rat Human DTXSID6020224 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6020224 TK.Half.Life NA 2.073 hours 1compartment NA NA Rat Human -DTXSID6020224 Css NA 0.2547 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020224 Css NA 1.532 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020224 Css NA 0.2026 mg/L PBTK NA 50% Rat Human -DTXSID6020224 Css NA 0.9141 mg/L PBTK NA 95% Rat Human -DTXSID6020226 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020226 Fup NA 0.2377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020226 Vd NA 0.3114 L/kg 1compartment NA NA Human Human -DTXSID6020226 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020226 TK.Half.Life NA 8.475 hours 1compartment NA NA Human Human -DTXSID6020226 Css NA 3.392 mg/L 3compartmentss NA 50% Human Human -DTXSID6020226 Css NA 12.7 mg/L 3compartmentss NA 95% Human Human -DTXSID6020226 Css NA 2.209 mg/L PBTK NA 50% Human Human -DTXSID6020226 Css NA 7.718 mg/L PBTK NA 95% Human Human -DTXSID6020226 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020226 Fup NA 0.2377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020226 Vd NA 0.3332 L/kg 1compartment NA NA Rat Human -DTXSID6020226 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020226 TK.Half.Life NA 3.09 hours 1compartment NA NA Rat Human -DTXSID6020226 Css NA 0.947 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020226 Css NA 2.929 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020226 Css NA 0.5826 mg/L PBTK NA 50% Rat Human -DTXSID6020226 Css NA 1.659 mg/L PBTK NA 95% Rat Human -DTXSID6020274 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020274 Fup NA 0.0741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020274 Vd NA 1.891 L/kg 1compartment NA NA Human Human +DTXSID6020224 Css NA 0.01578 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020224 Css NA 0.1225 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020224 Css NA 0.0125 mg/L PBTK NA 50% Rat Human +DTXSID6020224 Css NA 0.08006 mg/L PBTK NA 95% Rat Human +DTXSID6020274 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020274 Fup 0.0438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020274 Vd NA 1.983 L/kg 1compartment NA NA Human Human DTXSID6020274 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020274 TK.Half.Life NA 11.08 hours 1compartment NA NA Human Human -DTXSID6020274 Css NA 0.7834 mg/L 3compartmentss NA 50% Human Human -DTXSID6020274 Css NA 5.211 mg/L 3compartmentss NA 95% Human Human -DTXSID6020274 Css NA 0.5199 mg/L PBTK NA 50% Human Human -DTXSID6020274 Css NA 3.285 mg/L PBTK NA 95% Human Human -DTXSID6020274 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020274 Fup NA 0.0741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020274 Vd NA 1.426 L/kg 1compartment NA NA Rat Human +DTXSID6020274 TK.Half.Life NA 11.76 hours 1compartment NA NA Human Human +DTXSID6020274 Css NA 0.7842 mg/L 3compartmentss NA 50% Human Human +DTXSID6020274 Css NA 6.154 mg/L 3compartmentss NA 95% Human Human +DTXSID6020274 Css NA 0.5109 mg/L PBTK NA 50% Human Human +DTXSID6020274 Css NA 3.835 mg/L PBTK NA 95% Human Human +DTXSID6020274 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020274 Fup 0.0438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020274 Vd NA 1.484 L/kg 1compartment NA NA Rat Human DTXSID6020274 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020274 TK.Half.Life NA 3.765 hours 1compartment NA NA Rat Human -DTXSID6020274 Css NA 0.4328 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020274 Css NA 2.206 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020274 Css NA 0.2714 mg/L PBTK NA 50% Rat Human -DTXSID6020274 Css NA 1.312 mg/L PBTK NA 95% Rat Human -DTXSID6020276 Clint NA 16.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020276 Fup NA 0.4327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020276 Vd NA 0.4427 L/kg 1compartment NA NA Human Human +DTXSID6020274 TK.Half.Life NA 3.849 hours 1compartment NA NA Rat Human +DTXSID6020274 Css NA 0.1031 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020274 Css NA 0.6164 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020274 Css NA 0.06585 mg/L PBTK NA 50% Rat Human +DTXSID6020274 Css NA 0.3762 mg/L PBTK NA 95% Rat Human +DTXSID6020276 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020276 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020276 Vd NA 0.4138 L/kg 1compartment NA NA Human Human DTXSID6020276 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020276 TK.Half.Life NA 0.5445 hours 1compartment NA NA Human Human -DTXSID6020276 Css NA 0.06609 mg/L 3compartmentss NA 50% Human Human -DTXSID6020276 Css NA 0.4978 mg/L 3compartmentss NA 95% Human Human -DTXSID6020276 Css NA 0.04749 mg/L PBTK NA 50% Human Human -DTXSID6020276 Css NA 0.3278 mg/L PBTK NA 95% Human Human -DTXSID6020276 Clint NA 16.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020276 Fup NA 0.4327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020276 Vd NA 0.4466 L/kg 1compartment NA NA Rat Human +DTXSID6020276 TK.Half.Life NA 7.084 hours 1compartment NA NA Human Human +DTXSID6020276 Css NA 1.944 mg/L 3compartmentss NA 50% Human Human +DTXSID6020276 Css NA 8.124 mg/L 3compartmentss NA 95% Human Human +DTXSID6020276 Css NA 1.368 mg/L PBTK NA 50% Human Human +DTXSID6020276 Css NA 5.151 mg/L PBTK NA 95% Human Human +DTXSID6020276 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020276 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020276 Vd NA 0.4166 L/kg 1compartment NA NA Rat Human DTXSID6020276 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020276 TK.Half.Life NA 0.2863 hours 1compartment NA NA Rat Human -DTXSID6020276 Css NA 0.03482 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020276 Css NA 0.2155 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020276 Css NA 0.02397 mg/L PBTK NA 50% Rat Human -DTXSID6020276 Css NA 0.1325 mg/L PBTK NA 95% Rat Human -DTXSID6020278 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020278 Fup NA 0.2524 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020278 Vd NA 1.439 L/kg 1compartment NA NA Human Human -DTXSID6020278 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID6020278 TK.Half.Life NA 46.93 hours 1compartment NA NA Human Human -DTXSID6020278 Css NA 3.618 mg/L 3compartmentss NA 50% Human Human -DTXSID6020278 Css NA 12.88 mg/L 3compartmentss NA 95% Human Human -DTXSID6020278 Css NA 2.689 mg/L PBTK NA 50% Human Human -DTXSID6020278 Css NA 8.508 mg/L PBTK NA 95% Human Human -DTXSID6020278 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020278 Fup NA 0.2524 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020278 Vd NA 1.156 L/kg 1compartment NA NA Rat Human -DTXSID6020278 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6020278 TK.Half.Life NA 10.75 hours 1compartment NA NA Rat Human -DTXSID6020278 Css NA 0.9912 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020278 Css NA 2.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020278 Css NA 0.7024 mg/L PBTK NA 50% Rat Human -DTXSID6020278 Css NA 1.777 mg/L PBTK NA 95% Rat Human -DTXSID6020309 Clint NA 1.852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020309 Fup NA 0.6233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020309 Vd NA 1.236 L/kg 1compartment NA NA Human Human -DTXSID6020309 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020309 TK.Half.Life NA 3.809 hours 1compartment NA NA Human Human -DTXSID6020309 Css NA 0.2966 mg/L 3compartmentss NA 50% Human Human -DTXSID6020309 Css NA 2.299 mg/L 3compartmentss NA 95% Human Human -DTXSID6020309 Css NA 0.2554 mg/L PBTK NA 50% Human Human -DTXSID6020309 Css NA 1.516 mg/L PBTK NA 95% Human Human -DTXSID6020309 Clint NA 1.852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020309 Fup NA 0.6233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020309 Vd NA 1.112 L/kg 1compartment NA NA Rat Human -DTXSID6020309 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020309 TK.Half.Life NA 1.697 hours 1compartment NA NA Rat Human -DTXSID6020309 Css NA 0.1272 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020309 Css NA 0.8547 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020309 Css NA 0.1066 mg/L PBTK NA 50% Rat Human -DTXSID6020309 Css NA 0.5214 mg/L PBTK NA 95% Rat Human -DTXSID6020355 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020355 Fup NA 0.3287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020355 Vd NA 0.3263 L/kg 1compartment NA NA Human Human +DTXSID6020276 TK.Half.Life NA 2.43 hours 1compartment NA NA Rat Human +DTXSID6020276 Css NA 0.1238 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020276 Css NA 0.4429 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020276 Css NA 0.086 mg/L PBTK NA 50% Rat Human +DTXSID6020276 Css NA 0.267 mg/L PBTK NA 95% Rat Human +DTXSID6020278 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020278 Fup 0.0751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020278 Vd NA 0.7695 L/kg 1compartment NA NA Human Human +DTXSID6020278 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6020278 TK.Half.Life NA 2.433 hours 1compartment NA NA Human Human +DTXSID6020278 Css NA 0.3828 mg/L 3compartmentss NA 50% Human Human +DTXSID6020278 Css NA 2.979 mg/L 3compartmentss NA 95% Human Human +DTXSID6020278 Css NA 0.2414 mg/L PBTK NA 50% Human Human +DTXSID6020278 Css NA 1.778 mg/L PBTK NA 95% Human Human +DTXSID6020278 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020278 Fup 0.0751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020278 Vd NA 0.612 L/kg 1compartment NA NA Rat Human +DTXSID6020278 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6020278 TK.Half.Life NA 1.129 hours 1compartment NA NA Rat Human +DTXSID6020278 Css NA 0.05016 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020278 Css NA 0.2961 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020278 Css NA 0.03073 mg/L PBTK NA 50% Rat Human +DTXSID6020278 Css NA 0.173 mg/L PBTK NA 95% Rat Human +DTXSID6020355 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020355 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020355 Vd NA 0.4597 L/kg 1compartment NA NA Human Human DTXSID6020355 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020355 TK.Half.Life NA 6.424 hours 1compartment NA NA Human Human -DTXSID6020355 Css NA 2.46 mg/L 3compartmentss NA 50% Human Human -DTXSID6020355 Css NA 9.421 mg/L 3compartmentss NA 95% Human Human -DTXSID6020355 Css NA 1.628 mg/L PBTK NA 50% Human Human -DTXSID6020355 Css NA 5.723 mg/L PBTK NA 95% Human Human -DTXSID6020355 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020355 Fup NA 0.3287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020355 Vd NA 0.3339 L/kg 1compartment NA NA Rat Human +DTXSID6020355 TK.Half.Life NA 3.868 hours 1compartment NA NA Human Human +DTXSID6020355 Css NA 1.095 mg/L 3compartmentss NA 50% Human Human +DTXSID6020355 Css NA 6.373 mg/L 3compartmentss NA 95% Human Human +DTXSID6020355 Css NA 0.8119 mg/L PBTK NA 50% Human Human +DTXSID6020355 Css NA 3.944 mg/L PBTK NA 95% Human Human +DTXSID6020355 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020355 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020355 Vd NA 0.4788 L/kg 1compartment NA NA Rat Human DTXSID6020355 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020355 TK.Half.Life NA 2.24 hours 1compartment NA NA Rat Human -DTXSID6020355 Css NA 0.6691 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020355 Css NA 2.241 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020355 Css NA 0.4216 mg/L PBTK NA 50% Rat Human -DTXSID6020355 Css NA 1.277 mg/L PBTK NA 95% Rat Human -DTXSID6020357 Clint NA 78.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020357 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020357 Vd NA 0.7057 L/kg 1compartment NA NA Human Human +DTXSID6020355 TK.Half.Life NA 1.373 hours 1compartment NA NA Rat Human +DTXSID6020355 Css NA 0.06514 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020355 Css NA 0.3713 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020355 Css NA 0.04795 mg/L PBTK NA 50% Rat Human +DTXSID6020355 Css NA 0.222 mg/L PBTK NA 95% Rat Human +DTXSID6020357 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020357 Fup 0.791 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020357 Vd NA 0.4185 L/kg 1compartment NA NA Human Human DTXSID6020357 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020357 TK.Half.Life NA 0.4297 hours 1compartment NA NA Human Human -DTXSID6020357 Css NA 0.00662 mg/L 3compartmentss NA 50% Human Human -DTXSID6020357 Css NA 0.09476 mg/L 3compartmentss NA 95% Human Human -DTXSID6020357 Css NA 0.005378 mg/L PBTK NA 50% Human Human -DTXSID6020357 Css NA 0.06762 mg/L PBTK NA 95% Human Human -DTXSID6020357 Clint NA 78.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020357 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020357 Vd NA 0.7553 L/kg 1compartment NA NA Rat Human +DTXSID6020357 TK.Half.Life NA 3.423 hours 1compartment NA NA Human Human +DTXSID6020357 Css NA 0.9688 mg/L 3compartmentss NA 50% Human Human +DTXSID6020357 Css NA 5.738 mg/L 3compartmentss NA 95% Human Human +DTXSID6020357 Css NA 0.7083 mg/L PBTK NA 50% Human Human +DTXSID6020357 Css NA 3.533 mg/L PBTK NA 95% Human Human +DTXSID6020357 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020357 Fup 0.791 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020357 Vd NA 0.4468 L/kg 1compartment NA NA Rat Human DTXSID6020357 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020357 TK.Half.Life NA 0.2039 hours 1compartment NA NA Rat Human -DTXSID6020357 Css NA 0.003416 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020357 Css NA 0.03994 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020357 Css NA 0.002723 mg/L PBTK NA 50% Rat Human -DTXSID6020357 Css NA 0.02827 mg/L PBTK NA 95% Rat Human -DTXSID6020359 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020359 Fup NA 0.9327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020359 Vd NA 1.202 L/kg 1compartment NA NA Human Human +DTXSID6020357 TK.Half.Life NA 1.245 hours 1compartment NA NA Rat Human +DTXSID6020357 Css NA 0.02531 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020357 Css NA 0.17 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020357 Css NA 0.01764 mg/L PBTK NA 50% Rat Human +DTXSID6020357 Css NA 0.1029 mg/L PBTK NA 95% Rat Human +DTXSID6020359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020359 Fup 0.537 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020359 Vd NA 0.861 L/kg 1compartment NA NA Human Human DTXSID6020359 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020359 TK.Half.Life NA 8.705 hours 1compartment NA NA Human Human -DTXSID6020359 Css NA 0.8012 mg/L 3compartmentss NA 50% Human Human -DTXSID6020359 Css NA 2.97 mg/L 3compartmentss NA 95% Human Human -DTXSID6020359 Css NA 0.7329 mg/L PBTK NA 50% Human Human -DTXSID6020359 Css NA 2.183 mg/L PBTK NA 95% Human Human -DTXSID6020359 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020359 Fup NA 0.9327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020359 Vd NA 1.148 L/kg 1compartment NA NA Rat Human +DTXSID6020359 TK.Half.Life NA 0.8165 hours 1compartment NA NA Human Human +DTXSID6020359 Css NA 0.02872 mg/L 3compartmentss NA 50% Human Human +DTXSID6020359 Css NA 0.308 mg/L 3compartmentss NA 95% Human Human +DTXSID6020359 Css NA 0.02306 mg/L PBTK NA 50% Human Human +DTXSID6020359 Css NA 0.2112 mg/L PBTK NA 95% Human Human +DTXSID6020359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020359 Fup 0.537 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020359 Vd NA 0.8199 L/kg 1compartment NA NA Rat Human DTXSID6020359 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020359 TK.Half.Life NA 2.742 hours 1compartment NA NA Rat Human -DTXSID6020359 Css NA 0.2041 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020359 Css NA 0.7391 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020359 Css NA 0.1839 mg/L PBTK NA 50% Rat Human -DTXSID6020359 Css NA 0.4977 mg/L PBTK NA 95% Rat Human -DTXSID6020432 Clint NA 139.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020432 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020432 Vd NA 2.132 L/kg 1compartment NA NA Human Human -DTXSID6020432 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020432 TK.Half.Life NA 3.51 hours 1compartment NA NA Human Human -DTXSID6020432 Css NA 0.1246 mg/L 3compartmentss NA 50% Human Human -DTXSID6020432 Css NA 1.001 mg/L 3compartmentss NA 95% Human Human -DTXSID6020432 Css NA 0.08231 mg/L PBTK NA 50% Human Human -DTXSID6020432 Css NA 0.6292 mg/L PBTK NA 95% Human Human -DTXSID6020432 Clint NA 139.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020432 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020432 Vd NA 1.596 L/kg 1compartment NA NA Rat Human +DTXSID6020359 TK.Half.Life NA 0.3888 hours 1compartment NA NA Rat Human +DTXSID6020359 Css NA 0.001022 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020359 Css NA 0.01306 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020359 Css NA 0.0008168 mg/L PBTK NA 50% Rat Human +DTXSID6020359 Css NA 0.008682 mg/L PBTK NA 95% Rat Human +DTXSID6020432 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020432 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020432 Vd NA 1.582 L/kg 1compartment NA NA Human Human +DTXSID6020432 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6020432 TK.Half.Life NA 14.21 hours 1compartment NA NA Human Human +DTXSID6020432 Css NA 1.381 mg/L 3compartmentss NA 50% Human Human +DTXSID6020432 Css NA 11.89 mg/L 3compartmentss NA 95% Human Human +DTXSID6020432 Css NA 0.8696 mg/L PBTK NA 50% Human Human +DTXSID6020432 Css NA 7.343 mg/L PBTK NA 95% Human Human +DTXSID6020432 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020432 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020432 Vd NA 1.174 L/kg 1compartment NA NA Rat Human DTXSID6020432 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020432 TK.Half.Life NA 1.119 hours 1compartment NA NA Rat Human -DTXSID6020432 Css NA 0.07132 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020432 Css NA 0.4393 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020432 Css NA 0.04442 mg/L PBTK NA 50% Rat Human -DTXSID6020432 Css NA 0.2678 mg/L PBTK NA 95% Rat Human +DTXSID6020432 TK.Half.Life NA 5.332 hours 1compartment NA NA Rat Human +DTXSID6020432 Css NA 0.1789 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020432 Css NA 1.244 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020432 Css NA 0.1099 mg/L PBTK NA 50% Rat Human +DTXSID6020432 Css NA 0.7247 mg/L PBTK NA 95% Rat Human DTXSID6020480 Clint 863 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6020480 Fup NA 0.785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020480 Vd NA 1.403 L/kg 1compartment NA NA Human Human +DTXSID6020480 Fup 0.572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020480 Vd NA 1.702 L/kg 1compartment NA NA Human Human DTXSID6020480 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020480 TK.Half.Life NA 0.7811 hours 1compartment NA NA Human Human -DTXSID6020480 Css NA 0.0007167 mg/L 3compartmentss NA 50% Human Human -DTXSID6020480 Css NA 0.00843 mg/L 3compartmentss NA 95% Human Human -DTXSID6020480 Css NA 0.0006348 mg/L PBTK NA 50% Human Human -DTXSID6020480 Css NA 0.006042 mg/L PBTK NA 95% Human Human +DTXSID6020480 TK.Half.Life NA 1.06 hours 1compartment NA NA Human Human +DTXSID6020480 Css NA 0.0003768 mg/L 3compartmentss NA 50% Human Human +DTXSID6020480 Css NA 0.008863 mg/L 3compartmentss NA 95% Human Human +DTXSID6020480 Css NA 0.0003216 mg/L PBTK NA 50% Human Human +DTXSID6020480 Css NA 0.006416 mg/L PBTK NA 95% Human Human DTXSID6020480 Clint 863 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6020480 Fup NA 0.785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020480 Vd NA 1.265 L/kg 1compartment NA NA Rat Human +DTXSID6020480 Fup 0.572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020480 Vd NA 1.426 L/kg 1compartment NA NA Rat Human DTXSID6020480 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020480 TK.Half.Life NA 0.3031 hours 1compartment NA NA Rat Human -DTXSID6020480 Css NA 0.0003697 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020480 Css NA 0.003825 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020480 Css NA 0.0003304 mg/L PBTK NA 50% Rat Human -DTXSID6020480 Css NA 0.00272 mg/L PBTK NA 95% Rat Human -DTXSID6020484 Clint NA 41.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020484 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020484 Vd NA 0.8379 L/kg 1compartment NA NA Human Human +DTXSID6020480 TK.Half.Life NA 0.3821 hours 1compartment NA NA Rat Human +DTXSID6020480 Css NA 5.452e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020480 Css NA 0.001071 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020480 Css NA 4.808e-05 mg/L PBTK NA 50% Rat Human +DTXSID6020480 Css NA 0.0007812 mg/L PBTK NA 95% Rat Human +DTXSID6020484 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020484 Fup 0.0934 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020484 Vd NA 1.208 L/kg 1compartment NA NA Human Human DTXSID6020484 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020484 TK.Half.Life NA 2.394 hours 1compartment NA NA Human Human -DTXSID6020484 Css NA 0.3484 mg/L 3compartmentss NA 50% Human Human -DTXSID6020484 Css NA 2.645 mg/L 3compartmentss NA 95% Human Human -DTXSID6020484 Css NA 0.2148 mg/L PBTK NA 50% Human Human -DTXSID6020484 Css NA 1.629 mg/L PBTK NA 95% Human Human -DTXSID6020484 Clint NA 41.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020484 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020484 Vd NA 0.6455 L/kg 1compartment NA NA Rat Human +DTXSID6020484 TK.Half.Life NA 8.858 hours 1compartment NA NA Human Human +DTXSID6020484 Css NA 1.022 mg/L 3compartmentss NA 50% Human Human +DTXSID6020484 Css NA 6.824 mg/L 3compartmentss NA 95% Human Human +DTXSID6020484 Css NA 0.6626 mg/L PBTK NA 50% Human Human +DTXSID6020484 Css NA 4.223 mg/L PBTK NA 95% Human Human +DTXSID6020484 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020484 Fup 0.0934 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020484 Vd NA 0.9333 L/kg 1compartment NA NA Rat Human DTXSID6020484 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020484 TK.Half.Life NA 1.059 hours 1compartment NA NA Rat Human -DTXSID6020484 Css NA 0.202 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020484 Css NA 1.246 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020484 Css NA 0.1166 mg/L PBTK NA 50% Rat Human -DTXSID6020484 Css NA 0.6966 mg/L PBTK NA 95% Rat Human +DTXSID6020484 TK.Half.Life NA 3.691 hours 1compartment NA NA Rat Human +DTXSID6020484 Css NA 0.1252 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020484 Css NA 0.6115 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020484 Css NA 0.07973 mg/L PBTK NA 50% Rat Human +DTXSID6020484 Css NA 0.366 mg/L PBTK NA 95% Rat Human DTXSID6020511 Clint 25.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020511 Fup 0.115 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6020511 Vd NA 1.129 L/kg 1compartment NA NA Human Human +DTXSID6020511 Vd NA 0.7167 L/kg 1compartment NA NA Human Human DTXSID6020511 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020511 TK.Half.Life NA 2.481 hours 1compartment NA NA Human Human -DTXSID6020511 Css NA 0.1808 mg/L 3compartmentss NA 50% Human Human -DTXSID6020511 Css NA 1.154 mg/L 3compartmentss NA 95% Human Human -DTXSID6020511 Css NA 0.1212 mg/L PBTK NA 50% Human Human -DTXSID6020511 Css NA 0.7384 mg/L PBTK NA 95% Human Human +DTXSID6020511 TK.Half.Life NA 1.528 hours 1compartment NA NA Human Human +DTXSID6020511 Css NA 0.1678 mg/L 3compartmentss NA 50% Human Human +DTXSID6020511 Css NA 1.067 mg/L 3compartmentss NA 95% Human Human +DTXSID6020511 Css NA 0.1094 mg/L PBTK NA 50% Human Human +DTXSID6020511 Css NA 0.6649 mg/L PBTK NA 95% Human Human DTXSID6020511 Clint 25.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6020511 Fup 0.115 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6020511 Vd NA 0.8862 L/kg 1compartment NA NA Rat Human +DTXSID6020511 Vd NA 0.5936 L/kg 1compartment NA NA Rat Human DTXSID6020511 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020511 TK.Half.Life NA 1.045 hours 1compartment NA NA Rat Human -DTXSID6020511 Css NA 0.09911 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020511 Css NA 0.4774 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020511 Css NA 0.06269 mg/L PBTK NA 50% Rat Human -DTXSID6020511 Css NA 0.2916 mg/L PBTK NA 95% Rat Human -DTXSID6020513 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020513 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020513 Vd NA 0.4732 L/kg 1compartment NA NA Human Human +DTXSID6020511 TK.Half.Life NA 0.7143 hours 1compartment NA NA Rat Human +DTXSID6020511 Css NA 0.02154 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020511 Css NA 0.1063 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020511 Css NA 0.01373 mg/L PBTK NA 50% Rat Human +DTXSID6020511 Css NA 0.0662 mg/L PBTK NA 95% Rat Human +DTXSID6020513 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020513 Fup 0.49 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020513 Vd NA 0.3585 L/kg 1compartment NA NA Human Human DTXSID6020513 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020513 TK.Half.Life NA 5.986 hours 1compartment NA NA Human Human -DTXSID6020513 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human -DTXSID6020513 Css NA 7.282 mg/L 3compartmentss NA 95% Human Human -DTXSID6020513 Css NA 1.074 mg/L PBTK NA 50% Human Human -DTXSID6020513 Css NA 4.538 mg/L PBTK NA 95% Human Human -DTXSID6020513 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020513 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020513 Vd NA 0.4747 L/kg 1compartment NA NA Rat Human +DTXSID6020513 TK.Half.Life NA 4.735 hours 1compartment NA NA Human Human +DTXSID6020513 Css NA 1.352 mg/L 3compartmentss NA 50% Human Human +DTXSID6020513 Css NA 6.692 mg/L 3compartmentss NA 95% Human Human +DTXSID6020513 Css NA 0.948 mg/L PBTK NA 50% Human Human +DTXSID6020513 Css NA 4.149 mg/L PBTK NA 95% Human Human +DTXSID6020513 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020513 Fup 0.49 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020513 Vd NA 0.3763 L/kg 1compartment NA NA Rat Human DTXSID6020513 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020513 TK.Half.Life NA 2.095 hours 1compartment NA NA Rat Human -DTXSID6020513 Css NA 0.4147 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020513 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020513 Css NA 0.285 mg/L PBTK NA 50% Rat Human -DTXSID6020513 Css NA 1.07 mg/L PBTK NA 95% Rat Human +DTXSID6020513 TK.Half.Life NA 1.694 hours 1compartment NA NA Rat Human +DTXSID6020513 Css NA 0.02596 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020513 Css NA 0.174 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020513 Css NA 0.0173 mg/L PBTK NA 50% Rat Human +DTXSID6020513 Css NA 0.1069 mg/L PBTK NA 95% Rat Human DTXSID6020515 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6020515 Fup NA 0.8411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6020515 Vd NA 0.7102 L/kg 1compartment NA NA Human Human DTXSID6020515 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6020515 TK.Half.Life NA 5.466 hours 1compartment NA NA Human Human -DTXSID6020515 Css NA 0.9674 mg/L 3compartmentss NA 50% Human Human -DTXSID6020515 Css NA 5.564 mg/L 3compartmentss NA 95% Human Human -DTXSID6020515 Css NA 0.7886 mg/L PBTK NA 50% Human Human -DTXSID6020515 Css NA 3.66 mg/L PBTK NA 95% Human Human +DTXSID6020515 Css NA 0.823 mg/L 3compartmentss NA 50% Human Human +DTXSID6020515 Css NA 4.919 mg/L 3compartmentss NA 95% Human Human +DTXSID6020515 Css NA 0.6726 mg/L PBTK NA 50% Human Human +DTXSID6020515 Css NA 3.157 mg/L PBTK NA 95% Human Human DTXSID6020515 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6020515 Fup NA 0.8411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6020515 Vd NA 0.7428 L/kg 1compartment NA NA Rat Human DTXSID6020515 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6020515 TK.Half.Life NA 1.947 hours 1compartment NA NA Rat Human -DTXSID6020515 Css NA 0.2494 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020515 Css NA 1.435 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020515 Css NA 0.1976 mg/L PBTK NA 50% Rat Human -DTXSID6020515 Css NA 0.8584 mg/L PBTK NA 95% Rat Human +DTXSID6020515 Css NA 0.0154 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020515 Css NA 0.1166 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020515 Css NA 0.01211 mg/L PBTK NA 50% Rat Human +DTXSID6020515 Css NA 0.07586 mg/L PBTK NA 95% Rat Human DTXSID6020517 Clint NA 0.2062 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6020517 Fup NA 0.705 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020517 Vd NA 1.045 L/kg 1compartment NA NA Human Human +DTXSID6020517 Vd NA 1.055 L/kg 1compartment NA NA Human Human DTXSID6020517 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020517 TK.Half.Life NA 7.2 hours 1compartment NA NA Human Human -DTXSID6020517 Css NA 0.7538 mg/L 3compartmentss NA 50% Human Human -DTXSID6020517 Css NA 4.809 mg/L 3compartmentss NA 95% Human Human -DTXSID6020517 Css NA 0.6454 mg/L PBTK NA 50% Human Human -DTXSID6020517 Css NA 3.129 mg/L PBTK NA 95% Human Human +DTXSID6020517 TK.Half.Life NA 7.269 hours 1compartment NA NA Human Human +DTXSID6020517 Css NA 0.626 mg/L 3compartmentss NA 50% Human Human +DTXSID6020517 Css NA 4.26 mg/L 3compartmentss NA 95% Human Human +DTXSID6020517 Css NA 0.5402 mg/L PBTK NA 50% Human Human +DTXSID6020517 Css NA 2.774 mg/L PBTK NA 95% Human Human DTXSID6020517 Clint NA 0.2062 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6020517 Fup NA 0.705 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020517 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID6020517 Vd NA 1.073 L/kg 1compartment NA NA Rat Human DTXSID6020517 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020517 TK.Half.Life NA 2.86 hours 1compartment NA NA Rat Human -DTXSID6020517 Css NA 0.2264 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020517 Css NA 1.541 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020517 Css NA 0.1882 mg/L PBTK NA 50% Rat Human -DTXSID6020517 Css NA 0.9228 mg/L PBTK NA 95% Rat Human +DTXSID6020517 TK.Half.Life NA 2.886 hours 1compartment NA NA Rat Human +DTXSID6020517 Css NA 0.01398 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020517 Css NA 0.1222 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020517 Css NA 0.01164 mg/L PBTK NA 50% Rat Human +DTXSID6020517 Css NA 0.07908 mg/L PBTK NA 95% Rat Human DTXSID6020561 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID6020561 Fup 0.006423 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID6020561 Vd NA 2.845 L/kg 1compartment NA NA Human Human DTXSID6020561 Days.Css NA 3276 Days PBTK NA NA Human Human DTXSID6020561 TK.Half.Life NA 20570 hours 1compartment NA NA Human Human -DTXSID6020561 Css NA 924 mg/L 3compartmentss NA 50% Human Human -DTXSID6020561 Css NA 2791 mg/L 3compartmentss NA 95% Human Human -DTXSID6020561 Css NA 626 mg/L PBTK NA 50% Human Human -DTXSID6020561 Css NA 1782 mg/L PBTK NA 95% Human Human +DTXSID6020561 Css NA 895.1 mg/L 3compartmentss NA 50% Human Human +DTXSID6020561 Css NA 2753 mg/L 3compartmentss NA 95% Human Human +DTXSID6020561 Css NA 607.6 mg/L PBTK NA 50% Human Human +DTXSID6020561 Css NA 1737 mg/L PBTK NA 95% Human Human DTXSID6020561 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID6020561 Fup 0.006423 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID6020561 Vd NA 2.125 L/kg 1compartment NA NA Rat Human -DTXSID6020561 Days.Css NA 1447 Days PBTK NA NA Rat Human +DTXSID6020561 Days.Css NA 1441 Days PBTK NA NA Rat Human DTXSID6020561 TK.Half.Life NA 1804 hours 1compartment NA NA Rat Human -DTXSID6020561 Css NA 252.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020561 Css NA 653.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020561 Css NA 162.1 mg/L PBTK NA 50% Rat Human -DTXSID6020561 Css NA 381.2 mg/L PBTK NA 95% Rat Human +DTXSID6020561 Css NA 56.47 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020561 Css NA 142.9 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020561 Css NA 37.6 mg/L PBTK NA 50% Rat Human +DTXSID6020561 Css NA 86.52 mg/L PBTK NA 95% Rat Human +DTXSID60205756 Clint 13 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID60205756 Fup 0.004 NA NA Williamson 2020 NA Human Human +DTXSID60205756 Vd NA 3.054 L/kg 1compartment NA NA Human Human +DTXSID60205756 Days.Css NA 29 Days PBTK NA NA Human Human +DTXSID60205756 TK.Half.Life NA 154.3 hours 1compartment NA NA Human Human +DTXSID60205756 Css NA 5.223 mg/L 3compartmentss NA 50% Human Human +DTXSID60205756 Css NA 31.19 mg/L 3compartmentss NA 95% Human Human +DTXSID60205756 Css NA 3.6 mg/L PBTK NA 50% Human Human +DTXSID60205756 Css NA 21.38 mg/L PBTK NA 95% Human Human +DTXSID60205756 Clint 13 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID60205756 Fup 0.004 NA NA Williamson 2020 NA Rat Human +DTXSID60205756 Vd NA 2.286 L/kg 1compartment NA NA Rat Human +DTXSID60205756 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID60205756 TK.Half.Life NA 22.23 hours 1compartment NA NA Rat Human +DTXSID60205756 Css NA 0.1995 mg/L 3compartmentss NA 50% Rat Human +DTXSID60205756 Css NA 1.336 mg/L 3compartmentss NA 95% Rat Human +DTXSID60205756 Css NA 0.132 mg/L PBTK NA 50% Rat Human +DTXSID60205756 Css NA 0.883 mg/L PBTK NA 95% Rat Human DTXSID6020648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6020648 Fup 0.012 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6020648 Vd NA 0.1864 L/kg 1compartment NA NA Human Human DTXSID6020648 Days.Css NA 21 Days PBTK NA NA Human Human DTXSID6020648 TK.Half.Life NA 100.5 hours 1compartment NA NA Human Human -DTXSID6020648 Css NA 44.16 mg/L 3compartmentss NA 50% Human Human -DTXSID6020648 Css NA 263.7 mg/L 3compartmentss NA 95% Human Human -DTXSID6020648 Css NA 25.25 mg/L PBTK NA 50% Human Human -DTXSID6020648 Css NA 150 mg/L PBTK NA 95% Human Human +DTXSID6020648 Css NA 51.08 mg/L 3compartmentss NA 50% Human Human +DTXSID6020648 Css NA 328.9 mg/L 3compartmentss NA 95% Human Human +DTXSID6020648 Css NA 28.1 mg/L PBTK NA 50% Human Human +DTXSID6020648 Css NA 180.9 mg/L PBTK NA 95% Human Human DTXSID6020648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID6020648 Fup 0.012 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6020648 Vd NA 0.1835 L/kg 1compartment NA NA Rat Human DTXSID6020648 Days.Css NA 5 Days PBTK NA NA Rat Human DTXSID6020648 TK.Half.Life NA 33.71 hours 1compartment NA NA Rat Human -DTXSID6020648 Css NA 27.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020648 Css NA 139.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020648 Css NA 14.42 mg/L PBTK NA 50% Rat Human -DTXSID6020648 Css NA 75.13 mg/L PBTK NA 95% Rat Human +DTXSID6020648 Css NA 0.2582 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020648 Css NA 1.584 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020648 Css NA 0.1423 mg/L PBTK NA 50% Rat Human +DTXSID6020648 Css NA 0.8735 mg/L PBTK NA 95% Rat Human DTXSID6020690 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020690 Fup 8.62e-09 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020690 Vd NA 25.86 L/kg 1compartment NA NA Human Human -DTXSID6020690 Days.Css NA 8526 Days PBTK NA NA Human Human +DTXSID6020690 Days.Css NA 13780 Days PBTK NA NA Human Human DTXSID6020690 TK.Half.Life NA 1674000 hours 1compartment NA NA Human Human -DTXSID6020690 Css NA 5503 mg/L 3compartmentss NA 50% Human Human -DTXSID6020690 Css NA 11210 mg/L 3compartmentss NA 95% Human Human -DTXSID6020690 Css NA 4590 mg/L PBTK NA 50% Human Human -DTXSID6020690 Css NA 9151 mg/L PBTK NA 95% Human Human +DTXSID6020690 Css NA 5510 mg/L 3compartmentss NA 50% Human Human +DTXSID6020690 Css NA 10960 mg/L 3compartmentss NA 95% Human Human +DTXSID6020690 Css NA 4456 mg/L PBTK NA 50% Human Human +DTXSID6020690 Css NA 8864 mg/L PBTK NA 95% Human Human DTXSID6020690 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6020690 Fup 8.62e-09 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6020690 Vd NA 21.22 L/kg 1compartment NA NA Rat Human -DTXSID6020690 Days.Css NA 11150 Days PBTK NA NA Rat Human +DTXSID6020690 Days.Css NA 8526 Days PBTK NA NA Rat Human DTXSID6020690 TK.Half.Life NA 467700 hours 1compartment NA NA Rat Human -DTXSID6020690 Css NA 1657 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020690 Css NA 1657 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020690 Css NA 1325 mg/L PBTK NA 50% Rat Human -DTXSID6020690 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID6020690 Css NA 370.8 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020690 Css NA 371.6 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020690 Css NA 310.5 mg/L PBTK NA 50% Rat Human +DTXSID6020690 Css NA 311.2 mg/L PBTK NA 95% Rat Human DTXSID6020692 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020692 Fup 0.352 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6020692 Vd NA 0.4985 L/kg 1compartment NA NA Human Human +DTXSID6020692 Vd NA 0.4012 L/kg 1compartment NA NA Human Human DTXSID6020692 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020692 TK.Half.Life NA 9.177 hours 1compartment NA NA Human Human -DTXSID6020692 Css NA 2.112 mg/L 3compartmentss NA 50% Human Human -DTXSID6020692 Css NA 8.912 mg/L 3compartmentss NA 95% Human Human -DTXSID6020692 Css NA 1.503 mg/L PBTK NA 50% Human Human -DTXSID6020692 Css NA 5.554 mg/L PBTK NA 95% Human Human +DTXSID6020692 TK.Half.Life NA 7.375 hours 1compartment NA NA Human Human +DTXSID6020692 Css NA 2.099 mg/L 3compartmentss NA 50% Human Human +DTXSID6020692 Css NA 8.623 mg/L 3compartmentss NA 95% Human Human +DTXSID6020692 Css NA 1.453 mg/L PBTK NA 50% Human Human +DTXSID6020692 Css NA 5.337 mg/L PBTK NA 95% Human Human DTXSID6020692 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6020692 Fup 0.352 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6020692 Vd NA 0.5055 L/kg 1compartment NA NA Rat Human +DTXSID6020692 Vd NA 0.4245 L/kg 1compartment NA NA Rat Human DTXSID6020692 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020692 TK.Half.Life NA 3.168 hours 1compartment NA NA Rat Human -DTXSID6020692 Css NA 0.5806 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020692 Css NA 2.033 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020692 Css NA 0.3946 mg/L PBTK NA 50% Rat Human -DTXSID6020692 Css NA 1.192 mg/L PBTK NA 95% Rat Human -DTXSID6020696 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020696 Fup NA 0.8878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020696 Vd NA 0.6977 L/kg 1compartment NA NA Human Human +DTXSID6020692 TK.Half.Life NA 2.658 hours 1compartment NA NA Rat Human +DTXSID6020692 Css NA 0.1363 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020692 Css NA 0.4705 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020692 Css NA 0.09279 mg/L PBTK NA 50% Rat Human +DTXSID6020692 Css NA 0.2819 mg/L PBTK NA 95% Rat Human +DTXSID6020694 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020694 Fup 0.498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020694 Vd NA 0.6768 L/kg 1compartment NA NA Human Human +DTXSID6020694 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6020694 TK.Half.Life NA 8.854 hours 1compartment NA NA Human Human +DTXSID6020694 Css NA 1.356 mg/L 3compartmentss NA 50% Human Human +DTXSID6020694 Css NA 7.231 mg/L 3compartmentss NA 95% Human Human +DTXSID6020694 Css NA 1.062 mg/L PBTK NA 50% Human Human +DTXSID6020694 Css NA 4.654 mg/L PBTK NA 95% Human Human +DTXSID6020694 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat +DTXSID6020694 Fup 0.6935 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat +DTXSID6020694 Vd NA 0.82 L/kg 1compartment NA NA Rat Rat +DTXSID6020694 Days.Css NA 0 Days PBTK NA NA Rat Rat +DTXSID6020694 TK.Half.Life NA 2.614 hours 1compartment NA NA Rat Rat +DTXSID6020694 Css NA 0.06127 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6020694 Css NA 0.3929 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6020694 Css NA 0.0511 mg/L PBTK NA 50% Rat Rat +DTXSID6020694 Css NA 0.2426 mg/L PBTK NA 95% Rat Rat +DTXSID6020696 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020696 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020696 Vd NA 0.6039 L/kg 1compartment NA NA Human Human DTXSID6020696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020696 TK.Half.Life NA 5.085 hours 1compartment NA NA Human Human -DTXSID6020696 Css NA 0.949 mg/L 3compartmentss NA 50% Human Human -DTXSID6020696 Css NA 5.096 mg/L 3compartmentss NA 95% Human Human -DTXSID6020696 Css NA 0.7721 mg/L PBTK NA 50% Human Human -DTXSID6020696 Css NA 3.307 mg/L PBTK NA 95% Human Human -DTXSID6020696 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020696 Fup NA 0.8878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020696 Vd NA 0.7364 L/kg 1compartment NA NA Rat Human +DTXSID6020696 TK.Half.Life NA 5.645 hours 1compartment NA NA Human Human +DTXSID6020696 Css NA 0.9625 mg/L 3compartmentss NA 50% Human Human +DTXSID6020696 Css NA 6.237 mg/L 3compartmentss NA 95% Human Human +DTXSID6020696 Css NA 0.7578 mg/L PBTK NA 50% Human Human +DTXSID6020696 Css NA 3.922 mg/L PBTK NA 95% Human Human +DTXSID6020696 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020696 Fup 0.692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020696 Vd NA 0.6364 L/kg 1compartment NA NA Rat Human DTXSID6020696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020696 TK.Half.Life NA 1.829 hours 1compartment NA NA Rat Human -DTXSID6020696 Css NA 0.2425 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020696 Css NA 1.348 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020696 Css NA 0.1919 mg/L PBTK NA 50% Rat Human -DTXSID6020696 Css NA 0.8081 mg/L PBTK NA 95% Rat Human -DTXSID6020721 Clint NA 13.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020721 Fup NA 0.3503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020721 Vd NA 1.313 L/kg 1compartment NA NA Human Human +DTXSID6020696 TK.Half.Life NA 2.027 hours 1compartment NA NA Rat Human +DTXSID6020696 Css NA 0.01843 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020696 Css NA 0.1489 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020696 Css NA 0.01401 mg/L PBTK NA 50% Rat Human +DTXSID6020696 Css NA 0.09291 mg/L PBTK NA 95% Rat Human +DTXSID6020721 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020721 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020721 Vd NA 1.094 L/kg 1compartment NA NA Human Human DTXSID6020721 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020721 TK.Half.Life NA 2.027 hours 1compartment NA NA Human Human -DTXSID6020721 Css NA 0.1024 mg/L 3compartmentss NA 50% Human Human -DTXSID6020721 Css NA 0.708 mg/L 3compartmentss NA 95% Human Human -DTXSID6020721 Css NA 0.07916 mg/L PBTK NA 50% Human Human -DTXSID6020721 Css NA 0.4932 mg/L PBTK NA 95% Human Human -DTXSID6020721 Clint NA 13.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020721 Fup NA 0.3503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020721 Vd NA 1.096 L/kg 1compartment NA NA Rat Human +DTXSID6020721 TK.Half.Life NA 2.457 hours 1compartment NA NA Human Human +DTXSID6020721 Css NA 0.1822 mg/L 3compartmentss NA 50% Human Human +DTXSID6020721 Css NA 1.144 mg/L 3compartmentss NA 95% Human Human +DTXSID6020721 Css NA 0.1395 mg/L PBTK NA 50% Human Human +DTXSID6020721 Css NA 0.7823 mg/L PBTK NA 95% Human Human +DTXSID6020721 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020721 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020721 Vd NA 0.9446 L/kg 1compartment NA NA Rat Human DTXSID6020721 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020721 TK.Half.Life NA 0.8663 hours 1compartment NA NA Rat Human -DTXSID6020721 Css NA 0.05403 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020721 Css NA 0.2852 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020721 Css NA 0.04034 mg/L PBTK NA 50% Rat Human -DTXSID6020721 Css NA 0.1881 mg/L PBTK NA 95% Rat Human +DTXSID6020721 TK.Half.Life NA 1.141 hours 1compartment NA NA Rat Human +DTXSID6020721 Css NA 0.0209 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020721 Css NA 0.101 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020721 Css NA 0.01618 mg/L PBTK NA 50% Rat Human +DTXSID6020721 Css NA 0.06706 mg/L PBTK NA 95% Rat Human DTXSID6020771 Clint 4.673 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6020771 Fup 0.008 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6020771 Vd NA 0.1887 L/kg 1compartment NA NA Human Human DTXSID6020771 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID6020771 TK.Half.Life NA 17.49 hours 1compartment NA NA Human Human -DTXSID6020771 Css NA 10.84 mg/L 3compartmentss NA 50% Human Human -DTXSID6020771 Css NA 120.2 mg/L 3compartmentss NA 95% Human Human -DTXSID6020771 Css NA 10.06 mg/L PBTK NA 50% Human Human -DTXSID6020771 Css NA 80.14 mg/L PBTK NA 95% Human Human +DTXSID6020771 Css NA 9.961 mg/L 3compartmentss NA 50% Human Human +DTXSID6020771 Css NA 81.96 mg/L 3compartmentss NA 95% Human Human +DTXSID6020771 Css NA 9.961 mg/L PBTK NA 50% Human Human +DTXSID6020771 Css NA 81.95 mg/L PBTK NA 95% Human Human DTXSID6020771 Clint 4.673 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID6020771 Fup 0.008 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6020771 Vd NA 0.184 L/kg 1compartment NA NA Rat Human DTXSID6020771 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID6020771 TK.Half.Life NA 10.66 hours 1compartment NA NA Rat Human -DTXSID6020771 Css NA 5.526 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020771 Css NA 52.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020771 Css NA 4.91 mg/L PBTK NA 50% Rat Human -DTXSID6020771 Css NA 32.12 mg/L PBTK NA 95% Rat Human -DTXSID6020777 Clint NA 9.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020777 Fup NA 0.366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020777 Vd NA 3.467 L/kg 1compartment NA NA Human Human +DTXSID6020771 Css NA 1.116 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020771 Css NA 7.246 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020771 Css NA 1.154 mg/L PBTK NA 50% Rat Human +DTXSID6020771 Css NA 7.505 mg/L PBTK NA 95% Rat Human +DTXSID6020777 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020777 Fup 0.507 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020777 Vd NA 2.51 L/kg 1compartment NA NA Human Human DTXSID6020777 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020777 TK.Half.Life NA 4.854 hours 1compartment NA NA Human Human -DTXSID6020777 Css NA 0.07664 mg/L 3compartmentss NA 50% Human Human -DTXSID6020777 Css NA 0.5897 mg/L 3compartmentss NA 95% Human Human -DTXSID6020777 Css NA 0.08948 mg/L PBTK NA 50% Human Human -DTXSID6020777 Css NA 0.5329 mg/L PBTK NA 95% Human Human -DTXSID6020777 Clint NA 9.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020777 Fup NA 0.366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020777 Vd NA 3.482 L/kg 1compartment NA NA Rat Human +DTXSID6020777 TK.Half.Life NA 3.821 hours 1compartment NA NA Human Human +DTXSID6020777 Css NA 0.09256 mg/L 3compartmentss NA 50% Human Human +DTXSID6020777 Css NA 0.8288 mg/L 3compartmentss NA 95% Human Human +DTXSID6020777 Css NA 0.09786 mg/L PBTK NA 50% Human Human +DTXSID6020777 Css NA 0.653 mg/L PBTK NA 95% Human Human +DTXSID6020777 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020777 Fup 0.507 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020777 Vd NA 2.543 L/kg 1compartment NA NA Rat Human DTXSID6020777 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020777 TK.Half.Life NA 2.729 hours 1compartment NA NA Rat Human -DTXSID6020777 Css NA 0.0386 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020777 Css NA 0.2418 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020777 Css NA 0.04481 mg/L PBTK NA 50% Rat Human -DTXSID6020777 Css NA 0.2013 mg/L PBTK NA 95% Rat Human -DTXSID6020779 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020779 Fup NA 0.0212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020779 Vd NA 1.288 L/kg 1compartment NA NA Human Human -DTXSID6020779 Days.Css NA 128 Days PBTK NA NA Human Human -DTXSID6020779 TK.Half.Life NA 515.7 hours 1compartment NA NA Human Human -DTXSID6020779 Css NA 63.06 mg/L 3compartmentss NA 50% Human Human -DTXSID6020779 Css NA 336.9 mg/L 3compartmentss NA 95% Human Human -DTXSID6020779 Css NA 39.32 mg/L PBTK NA 50% Human Human -DTXSID6020779 Css NA 197.6 mg/L PBTK NA 95% Human Human -DTXSID6020779 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020779 Fup NA 0.0212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020779 Vd NA 0.9555 L/kg 1compartment NA NA Rat Human -DTXSID6020779 Days.Css NA 29 Days PBTK NA NA Rat Human -DTXSID6020779 TK.Half.Life NA 106.8 hours 1compartment NA NA Rat Human -DTXSID6020779 Css NA 17.64 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020779 Css NA 81.54 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020779 Css NA 10.27 mg/L PBTK NA 50% Rat Human -DTXSID6020779 Css NA 44.82 mg/L PBTK NA 95% Rat Human +DTXSID6020777 TK.Half.Life NA 2.19 hours 1compartment NA NA Rat Human +DTXSID6020777 Css NA 0.01045 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020777 Css NA 0.07639 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020777 Css NA 0.01129 mg/L PBTK NA 50% Rat Human +DTXSID6020777 Css NA 0.05638 mg/L PBTK NA 95% Rat Human +DTXSID6020779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020779 Fup 0.0265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020779 Vd NA 0.6519 L/kg 1compartment NA NA Human Human +DTXSID6020779 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6020779 TK.Half.Life NA 4.6 hours 1compartment NA NA Human Human +DTXSID6020779 Css NA 1.131 mg/L 3compartmentss NA 50% Human Human +DTXSID6020779 Css NA 10.67 mg/L 3compartmentss NA 95% Human Human +DTXSID6020779 Css NA 0.6862 mg/L PBTK NA 50% Human Human +DTXSID6020779 Css NA 6.315 mg/L PBTK NA 95% Human Human +DTXSID6020779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020779 Fup 0.0265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020779 Vd NA 0.4982 L/kg 1compartment NA NA Rat Human +DTXSID6020779 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6020779 TK.Half.Life NA 2.183 hours 1compartment NA NA Rat Human +DTXSID6020779 Css NA 0.1454 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020779 Css NA 1.142 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020779 Css NA 0.08528 mg/L PBTK NA 50% Rat Human +DTXSID6020779 Css NA 0.651 mg/L PBTK NA 95% Rat Human +DTXSID60207957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60207957 Fup 0.0726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60207957 Vd NA 3.032 L/kg 1compartment NA NA Human Human +DTXSID60207957 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID60207957 TK.Half.Life NA 39.63 hours 1compartment NA NA Human Human +DTXSID60207957 Css NA 1.526 mg/L 3compartmentss NA 50% Human Human +DTXSID60207957 Css NA 9.841 mg/L 3compartmentss NA 95% Human Human +DTXSID60207957 Css NA 1.057 mg/L PBTK NA 50% Human Human +DTXSID60207957 Css NA 6.702 mg/L PBTK NA 95% Human Human +DTXSID60207957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60207957 Fup 0.0726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60207957 Vd NA 2.274 L/kg 1compartment NA NA Rat Human +DTXSID60207957 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID60207957 TK.Half.Life NA 6.267 hours 1compartment NA NA Rat Human +DTXSID60207957 Css NA 0.1956 mg/L 3compartmentss NA 50% Rat Human +DTXSID60207957 Css NA 1.088 mg/L 3compartmentss NA 95% Rat Human +DTXSID60207957 Css NA 0.1347 mg/L PBTK NA 50% Rat Human +DTXSID60207957 Css NA 0.7334 mg/L PBTK NA 95% Rat Human DTXSID6020802 Clint NA 0.03653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6020802 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6020802 Vd NA 0.7882 L/kg 1compartment NA NA Human Human DTXSID6020802 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6020802 TK.Half.Life NA 4.81 hours 1compartment NA NA Human Human -DTXSID6020802 Css NA 0.7716 mg/L 3compartmentss NA 50% Human Human -DTXSID6020802 Css NA 5.08 mg/L 3compartmentss NA 95% Human Human -DTXSID6020802 Css NA 0.6502 mg/L PBTK NA 50% Human Human -DTXSID6020802 Css NA 3.418 mg/L PBTK NA 95% Human Human +DTXSID6020802 Css NA 0.654 mg/L 3compartmentss NA 50% Human Human +DTXSID6020802 Css NA 4.137 mg/L 3compartmentss NA 95% Human Human +DTXSID6020802 Css NA 0.5532 mg/L PBTK NA 50% Human Human +DTXSID6020802 Css NA 2.686 mg/L PBTK NA 95% Human Human DTXSID6020802 Clint NA 0.03653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6020802 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6020802 Vd NA 0.8284 L/kg 1compartment NA NA Rat Human DTXSID6020802 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6020802 TK.Half.Life NA 1.775 hours 1compartment NA NA Rat Human -DTXSID6020802 Css NA 0.2037 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020802 Css NA 1.278 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020802 Css NA 0.1679 mg/L PBTK NA 50% Rat Human -DTXSID6020802 Css NA 0.7694 mg/L PBTK NA 95% Rat Human -DTXSID6020804 Clint NA 0.9244 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6020802 Css NA 0.01228 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020802 Css NA 0.1032 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020802 Css NA 0.01009 mg/L PBTK NA 50% Rat Human +DTXSID6020802 Css NA 0.06756 mg/L PBTK NA 95% Rat Human +DTXSID6020804 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6020804 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6020804 Vd NA 0.3029 L/kg 1compartment NA NA Human Human DTXSID6020804 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020804 TK.Half.Life NA 5.599 hours 1compartment NA NA Human Human -DTXSID6020804 Css NA 1.39 mg/L 3compartmentss NA 50% Human Human -DTXSID6020804 Css NA 8.737 mg/L 3compartmentss NA 95% Human Human -DTXSID6020804 Css NA 1.279 mg/L PBTK NA 50% Human Human -DTXSID6020804 Css NA 6.001 mg/L PBTK NA 95% Human Human -DTXSID6020804 Clint NA 0.9244 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6020804 TK.Half.Life NA 1.379 hours 1compartment NA NA Human Human +DTXSID6020804 Css NA 0.4132 mg/L 3compartmentss NA 50% Human Human +DTXSID6020804 Css NA 2.785 mg/L 3compartmentss NA 95% Human Human +DTXSID6020804 Css NA 0.3962 mg/L PBTK NA 50% Human Human +DTXSID6020804 Css NA 2.672 mg/L PBTK NA 95% Human Human +DTXSID6020804 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6020804 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6020804 Vd NA 0.3076 L/kg 1compartment NA NA Rat Human DTXSID6020804 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020804 TK.Half.Life NA 2.795 hours 1compartment NA NA Rat Human -DTXSID6020804 Css NA 0.7397 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020804 Css NA 4.032 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020804 Css NA 0.6588 mg/L PBTK NA 50% Rat Human -DTXSID6020804 Css NA 2.558 mg/L PBTK NA 95% Rat Human +DTXSID6020804 TK.Half.Life NA 0.8587 hours 1compartment NA NA Rat Human +DTXSID6020804 Css NA 0.04713 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020804 Css NA 0.2218 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020804 Css NA 0.04684 mg/L PBTK NA 50% Rat Human +DTXSID6020804 Css NA 0.2204 mg/L PBTK NA 95% Rat Human DTXSID6020856 Clint 0.2081 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID6020856 Fup 0.888 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6020856 Vd NA 1.71 L/kg 1compartment NA NA Human Human DTXSID6020856 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6020856 TK.Half.Life NA 9.333 hours 1compartment NA NA Human Human -DTXSID6020856 Css NA 0.5102 mg/L 3compartmentss NA 50% Human Human -DTXSID6020856 Css NA 1.541 mg/L 3compartmentss NA 95% Human Human -DTXSID6020856 Css NA 0.5043 mg/L PBTK NA 50% Human Human -DTXSID6020856 Css NA 1.288 mg/L PBTK NA 95% Human Human +DTXSID6020856 Css NA 0.4318 mg/L 3compartmentss NA 50% Human Human +DTXSID6020856 Css NA 1.315 mg/L 3compartmentss NA 95% Human Human +DTXSID6020856 Css NA 0.4279 mg/L PBTK NA 50% Human Human +DTXSID6020856 Css NA 1.114 mg/L PBTK NA 95% Human Human DTXSID6020856 Clint 0.3239 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID6020856 Fup 0.7131 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID6020856 Vd NA 1.499 L/kg 1compartment NA NA Rat Rat DTXSID6020856 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID6020856 TK.Half.Life NA 3.693 hours 1compartment NA NA Rat Rat -DTXSID6020856 Css NA 0.1912 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6020856 Css NA 1.375 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6020856 Css NA 0.172 mg/L PBTK NA 50% Rat Rat -DTXSID6020856 Css NA 0.842 mg/L PBTK NA 95% Rat Rat -DTXSID6020933 Clint NA 11.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020933 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020933 Vd NA 0.8713 L/kg 1compartment NA NA Human Human +DTXSID6020856 Css NA 0.01201 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6020856 Css NA 0.1048 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6020856 Css NA 0.01068 mg/L PBTK NA 50% Rat Rat +DTXSID6020856 Css NA 0.07027 mg/L PBTK NA 95% Rat Rat +DTXSID6020933 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020933 Fup 0.768 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020933 Vd NA 0.7444 L/kg 1compartment NA NA Human Human DTXSID6020933 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020933 TK.Half.Life NA 0.7097 hours 1compartment NA NA Human Human -DTXSID6020933 Css NA 0.04273 mg/L 3compartmentss NA 50% Human Human -DTXSID6020933 Css NA 0.4693 mg/L 3compartmentss NA 95% Human Human -DTXSID6020933 Css NA 0.03643 mg/L PBTK NA 50% Human Human -DTXSID6020933 Css NA 0.3505 mg/L PBTK NA 95% Human Human -DTXSID6020933 Clint NA 11.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020933 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020933 Vd NA 0.896 L/kg 1compartment NA NA Rat Human +DTXSID6020933 TK.Half.Life NA 6.284 hours 1compartment NA NA Human Human +DTXSID6020933 Css NA 0.9948 mg/L 3compartmentss NA 50% Human Human +DTXSID6020933 Css NA 6.239 mg/L 3compartmentss NA 95% Human Human +DTXSID6020933 Css NA 0.8162 mg/L PBTK NA 50% Human Human +DTXSID6020933 Css NA 3.983 mg/L PBTK NA 95% Human Human +DTXSID6020933 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020933 Fup 0.768 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020933 Vd NA 0.7642 L/kg 1compartment NA NA Rat Human DTXSID6020933 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020933 TK.Half.Life NA 0.364 hours 1compartment NA NA Rat Human -DTXSID6020933 Css NA 0.0209 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020933 Css NA 0.1753 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020933 Css NA 0.01764 mg/L PBTK NA 50% Rat Human -DTXSID6020933 Css NA 0.1227 mg/L PBTK NA 95% Rat Human -DTXSID6020937 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020937 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020937 Vd NA 2.278 L/kg 1compartment NA NA Human Human -DTXSID6020937 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID6020937 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human -DTXSID6020937 Css NA 5.766 mg/L 3compartmentss NA 50% Human Human -DTXSID6020937 Css NA 18.35 mg/L 3compartmentss NA 95% Human Human -DTXSID6020937 Css NA 4.315 mg/L PBTK NA 50% Human Human -DTXSID6020937 Css NA 12.3 mg/L PBTK NA 95% Human Human -DTXSID6020937 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020937 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020937 Vd NA 1.758 L/kg 1compartment NA NA Rat Human -DTXSID6020937 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID6020937 TK.Half.Life NA 18.69 hours 1compartment NA NA Rat Human -DTXSID6020937 Css NA 1.568 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020937 Css NA 4.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020937 Css NA 1.13 mg/L PBTK NA 50% Rat Human -DTXSID6020937 Css NA 2.563 mg/L PBTK NA 95% Rat Human +DTXSID6020933 TK.Half.Life NA 2.195 hours 1compartment NA NA Rat Human +DTXSID6020933 Css NA 0.05789 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020933 Css NA 0.3705 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020933 Css NA 0.04797 mg/L PBTK NA 50% Rat Human +DTXSID6020933 Css NA 0.2282 mg/L PBTK NA 95% Rat Human DTXSID6020939 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6020939 Fup NA 0.9384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020939 Vd NA 0.7094 L/kg 1compartment NA NA Human Human +DTXSID6020939 Vd NA 0.6869 L/kg 1compartment NA NA Human Human DTXSID6020939 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020939 TK.Half.Life NA 4.892 hours 1compartment NA NA Human Human -DTXSID6020939 Css NA 0.9142 mg/L 3compartmentss NA 50% Human Human -DTXSID6020939 Css NA 5.124 mg/L 3compartmentss NA 95% Human Human -DTXSID6020939 Css NA 0.7502 mg/L PBTK NA 50% Human Human -DTXSID6020939 Css NA 3.361 mg/L PBTK NA 95% Human Human +DTXSID6020939 TK.Half.Life NA 4.738 hours 1compartment NA NA Human Human +DTXSID6020939 Css NA 0.7832 mg/L 3compartmentss NA 50% Human Human +DTXSID6020939 Css NA 4.374 mg/L 3compartmentss NA 95% Human Human +DTXSID6020939 Css NA 0.6373 mg/L PBTK NA 50% Human Human +DTXSID6020939 Css NA 2.865 mg/L PBTK NA 95% Human Human DTXSID6020939 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6020939 Fup NA 0.9384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020939 Vd NA 0.7511 L/kg 1compartment NA NA Rat Human +DTXSID6020939 Vd NA 0.7331 L/kg 1compartment NA NA Rat Human DTXSID6020939 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020939 TK.Half.Life NA 1.765 hours 1compartment NA NA Rat Human -DTXSID6020939 Css NA 0.2336 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020939 Css NA 1.294 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020939 Css NA 0.186 mg/L PBTK NA 50% Rat Human -DTXSID6020939 Css NA 0.7778 mg/L PBTK NA 95% Rat Human -DTXSID6020985 Clint NA 4.128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020985 Fup NA 0.2846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6020985 Vd NA 0.8375 L/kg 1compartment NA NA Human Human +DTXSID6020939 TK.Half.Life NA 1.723 hours 1compartment NA NA Rat Human +DTXSID6020939 Css NA 0.01458 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020939 Css NA 0.09868 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020939 Css NA 0.01147 mg/L PBTK NA 50% Rat Human +DTXSID6020939 Css NA 0.06598 mg/L PBTK NA 95% Rat Human +DTXSID6020983 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020983 Fup 0.00668 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020983 Vd NA 2.82 L/kg 1compartment NA NA Human Human +DTXSID6020983 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID6020983 TK.Half.Life NA 66.71 hours 1compartment NA NA Human Human +DTXSID6020983 Css NA 3.15 mg/L 3compartmentss NA 50% Human Human +DTXSID6020983 Css NA 22.77 mg/L 3compartmentss NA 95% Human Human +DTXSID6020983 Css NA 2.117 mg/L PBTK NA 50% Human Human +DTXSID6020983 Css NA 14.7 mg/L PBTK NA 95% Human Human +DTXSID6020983 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020983 Fup 0.00668 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020983 Vd NA 2.106 L/kg 1compartment NA NA Rat Human +DTXSID6020983 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID6020983 TK.Half.Life NA 12.66 hours 1compartment NA NA Rat Human +DTXSID6020983 Css NA 0.4106 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020983 Css NA 2.452 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020983 Css NA 0.2726 mg/L PBTK NA 50% Rat Human +DTXSID6020983 Css NA 1.599 mg/L PBTK NA 95% Rat Human +DTXSID6020985 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020985 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6020985 Vd NA 0.6489 L/kg 1compartment NA NA Human Human DTXSID6020985 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6020985 TK.Half.Life NA 2.971 hours 1compartment NA NA Human Human -DTXSID6020985 Css NA 0.3505 mg/L 3compartmentss NA 50% Human Human -DTXSID6020985 Css NA 2.006 mg/L 3compartmentss NA 95% Human Human -DTXSID6020985 Css NA 0.2556 mg/L PBTK NA 50% Human Human -DTXSID6020985 Css NA 1.333 mg/L PBTK NA 95% Human Human -DTXSID6020985 Clint NA 4.128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020985 Fup NA 0.2846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6020985 Vd NA 0.7389 L/kg 1compartment NA NA Rat Human +DTXSID6020985 TK.Half.Life NA 2.521 hours 1compartment NA NA Human Human +DTXSID6020985 Css NA 0.4004 mg/L 3compartmentss NA 50% Human Human +DTXSID6020985 Css NA 2.36 mg/L 3compartmentss NA 95% Human Human +DTXSID6020985 Css NA 0.269 mg/L PBTK NA 50% Human Human +DTXSID6020985 Css NA 1.501 mg/L PBTK NA 95% Human Human +DTXSID6020985 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020985 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6020985 Vd NA 0.5708 L/kg 1compartment NA NA Rat Human DTXSID6020985 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6020985 TK.Half.Life NA 1.456 hours 1compartment NA NA Rat Human -DTXSID6020985 Css NA 0.1731 mg/L 3compartmentss NA 50% Rat Human -DTXSID6020985 Css NA 0.7439 mg/L 3compartmentss NA 95% Rat Human -DTXSID6020985 Css NA 0.1205 mg/L PBTK NA 50% Rat Human -DTXSID6020985 Css NA 0.4518 mg/L PBTK NA 95% Rat Human -DTXSID6021030 Clint 8.288 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID6021030 Fup 0.04368 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID6021030 Vd NA 1.517 L/kg 1compartment NA NA Human Human -DTXSID6021030 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6021030 TK.Half.Life NA 17.96 hours 1compartment NA NA Human Human -DTXSID6021030 Css NA 1.849 mg/L 3compartmentss NA 50% Human Human -DTXSID6021030 Css NA 13.67 mg/L 3compartmentss NA 95% Human Human -DTXSID6021030 Css NA 1.176 mg/L PBTK NA 50% Human Human -DTXSID6021030 Css NA 8.287 mg/L PBTK NA 95% Human Human -DTXSID6021030 Clint 8.288 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID6021030 Fup 0.04368 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID6021030 Vd NA 1.137 L/kg 1compartment NA NA Rat Human -DTXSID6021030 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021030 TK.Half.Life NA 6.796 hours 1compartment NA NA Rat Human -DTXSID6021030 Css NA 0.9998 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021030 Css NA 5.563 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021030 Css NA 0.6016 mg/L PBTK NA 50% Rat Human -DTXSID6021030 Css NA 3.137 mg/L PBTK NA 95% Rat Human +DTXSID6020985 TK.Half.Life NA 1.291 hours 1compartment NA NA Rat Human +DTXSID6020985 Css NA 0.04788 mg/L 3compartmentss NA 50% Rat Human +DTXSID6020985 Css NA 0.2038 mg/L 3compartmentss NA 95% Rat Human +DTXSID6020985 Css NA 0.03178 mg/L PBTK NA 50% Rat Human +DTXSID6020985 Css NA 0.1254 mg/L PBTK NA 95% Rat Human +DTXSID6021032 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021032 Fup 0.628 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021032 Vd NA 1.3 L/kg 1compartment NA NA Human Human +DTXSID6021032 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6021032 TK.Half.Life NA 1.125 hours 1compartment NA NA Human Human +DTXSID6021032 Css NA 0.03116 mg/L 3compartmentss NA 50% Human Human +DTXSID6021032 Css NA 0.3547 mg/L 3compartmentss NA 95% Human Human +DTXSID6021032 Css NA 0.02674 mg/L PBTK NA 50% Human Human +DTXSID6021032 Css NA 0.246 mg/L PBTK NA 95% Human Human +DTXSID6021032 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021032 Fup 0.628 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021032 Vd NA 1.166 L/kg 1compartment NA NA Rat Human +DTXSID6021032 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6021032 TK.Half.Life NA 0.4906 hours 1compartment NA NA Rat Human +DTXSID6021032 Css NA 0.003756 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021032 Css NA 0.03462 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021032 Css NA 0.003292 mg/L PBTK NA 50% Rat Human +DTXSID6021032 Css NA 0.0239 mg/L PBTK NA 95% Rat Human +DTXSID6021036 Clint NA 0.02149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6021036 Fup NA 0.9927 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6021036 Vd NA 0.9655 L/kg 1compartment NA NA Human Human +DTXSID6021036 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6021036 TK.Half.Life NA 6.123 hours 1compartment NA NA Human Human +DTXSID6021036 Css NA 0.648 mg/L 3compartmentss NA 50% Human Human +DTXSID6021036 Css NA 4.618 mg/L 3compartmentss NA 95% Human Human +DTXSID6021036 Css NA 0.5735 mg/L PBTK NA 50% Human Human +DTXSID6021036 Css NA 3.031 mg/L PBTK NA 95% Human Human +DTXSID6021036 Clint NA 0.02149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6021036 Fup NA 0.9927 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6021036 Vd NA 0.9768 L/kg 1compartment NA NA Rat Human +DTXSID6021036 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6021036 TK.Half.Life NA 2.137 hours 1compartment NA NA Rat Human +DTXSID6021036 Css NA 0.01225 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021036 Css NA 0.09864 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021036 Css NA 0.01044 mg/L PBTK NA 50% Rat Human +DTXSID6021036 Css NA 0.06582 mg/L PBTK NA 95% Rat Human DTXSID6021080 Clint 3.271 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6021080 Fup 0.16 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID6021080 Vd NA 1.206 L/kg 1compartment NA NA Human Human DTXSID6021080 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6021080 TK.Half.Life NA 9.236 hours 1compartment NA NA Human Human -DTXSID6021080 Css NA 1.096 mg/L 3compartmentss NA 50% Human Human -DTXSID6021080 Css NA 5.736 mg/L 3compartmentss NA 95% Human Human -DTXSID6021080 Css NA 0.6482 mg/L PBTK NA 50% Human Human -DTXSID6021080 Css NA 3.375 mg/L PBTK NA 95% Human Human +DTXSID6021080 Css NA 1.082 mg/L 3compartmentss NA 50% Human Human +DTXSID6021080 Css NA 5.611 mg/L 3compartmentss NA 95% Human Human +DTXSID6021080 Css NA 0.6268 mg/L PBTK NA 50% Human Human +DTXSID6021080 Css NA 3.251 mg/L PBTK NA 95% Human Human DTXSID6021080 Clint 3.271 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID6021080 Fup 0.16 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID6021080 Vd NA 0.86 L/kg 1compartment NA NA Rat Human DTXSID6021080 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021080 TK.Half.Life NA 4.063 hours 1compartment NA NA Rat Human -DTXSID6021080 Css NA 0.6902 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021080 Css NA 2.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021080 Css NA 0.3833 mg/L PBTK NA 50% Rat Human -DTXSID6021080 Css NA 1.571 mg/L PBTK NA 95% Rat Human -DTXSID6021082 Clint NA 29.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021082 Fup NA 0.0198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021082 Vd NA 0.206 L/kg 1compartment NA NA Human Human +DTXSID6021080 Css NA 0.1494 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021080 Css NA 0.6263 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021080 Css NA 0.08971 mg/L PBTK NA 50% Rat Human +DTXSID6021080 Css NA 0.376 mg/L PBTK NA 95% Rat Human +DTXSID6021082 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021082 Fup 0.0569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021082 Vd NA 0.1886 L/kg 1compartment NA NA Human Human DTXSID6021082 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021082 TK.Half.Life NA 1.544 hours 1compartment NA NA Human Human -DTXSID6021082 Css NA 1.264 mg/L 3compartmentss NA 50% Human Human -DTXSID6021082 Css NA 12.74 mg/L 3compartmentss NA 95% Human Human -DTXSID6021082 Css NA 0.7424 mg/L PBTK NA 50% Human Human -DTXSID6021082 Css NA 7.41 mg/L PBTK NA 95% Human Human -DTXSID6021082 Clint NA 29.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021082 Fup NA 0.0198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021082 Vd NA 0.1945 L/kg 1compartment NA NA Rat Human +DTXSID6021082 TK.Half.Life NA 0.7407 hours 1compartment NA NA Human Human +DTXSID6021082 Css NA 0.2892 mg/L 3compartmentss NA 50% Human Human +DTXSID6021082 Css NA 2.544 mg/L 3compartmentss NA 95% Human Human +DTXSID6021082 Css NA 0.1708 mg/L PBTK NA 50% Human Human +DTXSID6021082 Css NA 1.479 mg/L PBTK NA 95% Human Human +DTXSID6021082 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021082 Fup 0.0569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021082 Vd NA 0.1899 L/kg 1compartment NA NA Rat Human DTXSID6021082 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021082 TK.Half.Life NA 0.9534 hours 1compartment NA NA Rat Human -DTXSID6021082 Css NA 0.7273 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021082 Css NA 5.775 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021082 Css NA 0.3983 mg/L PBTK NA 50% Rat Human -DTXSID6021082 Css NA 3.128 mg/L PBTK NA 95% Rat Human -DTXSID6021084 Clint NA 33.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021084 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021084 Vd NA 37600 L/kg 1compartment NA NA Human Human -DTXSID6021084 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6021084 TK.Half.Life NA 744500 hours 1compartment NA NA Human Human -DTXSID6021084 Css NA 0.0002292 mg/L 3compartmentss NA 50% Human Human -DTXSID6021084 Css NA 0.001405 mg/L 3compartmentss NA 95% Human Human -DTXSID6021084 Css NA 1.666 mg/L PBTK NA 50% Human Human -DTXSID6021084 Css NA 9.283 mg/L PBTK NA 95% Human Human -DTXSID6021084 Clint NA 33.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021084 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021084 Vd NA 35640 L/kg 1compartment NA NA Rat Human -DTXSID6021084 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6021084 TK.Half.Life NA 133100 hours 1compartment NA NA Rat Human -DTXSID6021084 Css NA 0.000116 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021084 Css NA 0.0004977 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021084 Css NA 0.8948 mg/L PBTK NA 50% Rat Human -DTXSID6021084 Css NA 3.724 mg/L PBTK NA 95% Rat Human +DTXSID6021082 TK.Half.Life NA 0.4627 hours 1compartment NA NA Rat Human +DTXSID6021082 Css NA 0.003152 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021082 Css NA 0.02323 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021082 Css NA 0.001743 mg/L PBTK NA 50% Rat Human +DTXSID6021082 Css NA 0.01268 mg/L PBTK NA 95% Rat Human DTXSID6021086 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6021086 Fup 0.7926 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6021086 Vd NA 0.4631 L/kg 1compartment NA NA Human Human DTXSID6021086 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6021086 TK.Half.Life NA 3.779 hours 1compartment NA NA Human Human -DTXSID6021086 Css NA 1.108 mg/L 3compartmentss NA 50% Human Human -DTXSID6021086 Css NA 6.186 mg/L 3compartmentss NA 95% Human Human -DTXSID6021086 Css NA 0.8188 mg/L PBTK NA 50% Human Human -DTXSID6021086 Css NA 3.862 mg/L PBTK NA 95% Human Human +DTXSID6021086 Css NA 1.08 mg/L 3compartmentss NA 50% Human Human +DTXSID6021086 Css NA 6.299 mg/L 3compartmentss NA 95% Human Human +DTXSID6021086 Css NA 0.7946 mg/L PBTK NA 50% Human Human +DTXSID6021086 Css NA 3.902 mg/L PBTK NA 95% Human Human DTXSID6021086 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6021086 Fup 0.7926 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6021086 Vd NA 0.482 L/kg 1compartment NA NA Rat Human DTXSID6021086 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021086 TK.Half.Life NA 1.341 hours 1compartment NA NA Rat Human -DTXSID6021086 Css NA 0.2873 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021086 Css NA 1.558 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021086 Css NA 0.2032 mg/L PBTK NA 50% Rat Human -DTXSID6021086 Css NA 0.9004 mg/L PBTK NA 95% Rat Human -DTXSID6021113 Clint NA 11.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021113 Fup NA 0.1245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021113 Vd NA 2.879 L/kg 1compartment NA NA Human Human -DTXSID6021113 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6021113 TK.Half.Life NA 31.32 hours 1compartment NA NA Human Human -DTXSID6021113 Css NA 1.326 mg/L 3compartmentss NA 50% Human Human -DTXSID6021113 Css NA 7.64 mg/L 3compartmentss NA 95% Human Human -DTXSID6021113 Css NA 0.9282 mg/L PBTK NA 50% Human Human -DTXSID6021113 Css NA 5.164 mg/L PBTK NA 95% Human Human -DTXSID6021113 Clint NA 11.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021113 Fup NA 0.1245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021113 Vd NA 2.167 L/kg 1compartment NA NA Rat Human -DTXSID6021113 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6021113 TK.Half.Life NA 5.869 hours 1compartment NA NA Rat Human -DTXSID6021113 Css NA 0.7192 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021113 Css NA 3.182 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021113 Css NA 0.4814 mg/L PBTK NA 50% Rat Human -DTXSID6021113 Css NA 2.077 mg/L PBTK NA 95% Rat Human +DTXSID6021086 Css NA 0.06421 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021086 Css NA 0.3478 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021086 Css NA 0.04712 mg/L PBTK NA 50% Rat Human +DTXSID6021086 Css NA 0.2083 mg/L PBTK NA 95% Rat Human DTXSID6021117 Clint 0.5062 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6021117 Fup 0.97 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Human Human DTXSID6021117 Vd NA 1.015 L/kg 1compartment NA NA Human Human DTXSID6021117 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6021117 TK.Half.Life NA 3.927 hours 1compartment NA NA Human Human -DTXSID6021117 Css NA 0.6855 mg/L 3compartmentss NA 50% Human Human -DTXSID6021117 Css NA 3.219 mg/L 3compartmentss NA 95% Human Human -DTXSID6021117 Css NA 0.3927 mg/L PBTK NA 50% Human Human -DTXSID6021117 Css NA 1.876 mg/L PBTK NA 95% Human Human +DTXSID6021117 Css NA 0.6805 mg/L 3compartmentss NA 50% Human Human +DTXSID6021117 Css NA 3.202 mg/L 3compartmentss NA 95% Human Human +DTXSID6021117 Css NA 0.3787 mg/L PBTK NA 50% Human Human +DTXSID6021117 Css NA 1.791 mg/L PBTK NA 95% Human Human DTXSID6021117 Clint 0.8958 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID6021117 Fup 0.596 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID6021117 Vd NA 0.7491 L/kg 1compartment NA NA Rat Rat +DTXSID6021117 Vd 2.5 0.7491 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID6021117 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID6021117 TK.Half.Life NA 1.667 hours 1compartment NA NA Rat Rat -DTXSID6021117 Css NA 0.2676 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6021117 Css NA 1.443 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6021117 Css NA 0.1448 mg/L PBTK NA 50% Rat Rat -DTXSID6021117 Css NA 0.7791 mg/L PBTK NA 95% Rat Rat -DTXSID6021163 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021163 Fup NA 0.475 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021163 Vd NA 0.8122 L/kg 1compartment NA NA Human Human +DTXSID6021117 TK.Half.Life 1.4 1.667 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID6021117 Css 0.033 0.05884 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID6021117 Css 0.033 0.3095 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID6021117 Css 0.033 0.03414 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID6021117 Css 0.033 0.1796 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID6021163 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021163 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021163 Vd NA 0.7104 L/kg 1compartment NA NA Human Human DTXSID6021163 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6021163 TK.Half.Life NA 11.41 hours 1compartment NA NA Human Human -DTXSID6021163 Css NA 1.51 mg/L 3compartmentss NA 50% Human Human -DTXSID6021163 Css NA 7.48 mg/L 3compartmentss NA 95% Human Human -DTXSID6021163 Css NA 1.178 mg/L PBTK NA 50% Human Human -DTXSID6021163 Css NA 4.825 mg/L PBTK NA 95% Human Human -DTXSID6021163 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021163 Fup NA 0.475 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021163 Vd NA 0.7544 L/kg 1compartment NA NA Rat Human +DTXSID6021163 TK.Half.Life NA 12.29 hours 1compartment NA NA Human Human +DTXSID6021163 Css NA 1.019 mg/L 3compartmentss NA 50% Human Human +DTXSID6021163 Css NA 4.626 mg/L 3compartmentss NA 95% Human Human +DTXSID6021163 Css NA 0.7597 mg/L PBTK NA 50% Human Human +DTXSID6021163 Css NA 2.962 mg/L PBTK NA 95% Human Human +DTXSID6021163 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021163 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021163 Vd NA 0.6604 L/kg 1compartment NA NA Rat Human DTXSID6021163 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021163 TK.Half.Life NA 3.529 hours 1compartment NA NA Rat Human -DTXSID6021163 Css NA 0.4094 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021163 Css NA 1.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021163 Css NA 0.3062 mg/L PBTK NA 50% Rat Human -DTXSID6021163 Css NA 1.062 mg/L PBTK NA 95% Rat Human +DTXSID6021163 TK.Half.Life NA 3.823 hours 1compartment NA NA Rat Human +DTXSID6021163 Css NA 0.005458 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021163 Css NA 0.02623 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021163 Css NA 0.003906 mg/L PBTK NA 50% Rat Human +DTXSID6021163 Css NA 0.01613 mg/L PBTK NA 95% Rat Human DTXSID6021165 Clint NA 2.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021165 Fup NA 0.7242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021165 Vd NA 1.692 L/kg 1compartment NA NA Human Human DTXSID6021165 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6021165 TK.Half.Life NA 3.191 hours 1compartment NA NA Human Human -DTXSID6021165 Css NA 0.1617 mg/L 3compartmentss NA 50% Human Human -DTXSID6021165 Css NA 1.334 mg/L 3compartmentss NA 95% Human Human -DTXSID6021165 Css NA 0.156 mg/L PBTK NA 50% Human Human -DTXSID6021165 Css NA 0.9543 mg/L PBTK NA 95% Human Human +DTXSID6021165 Css NA 0.1356 mg/L 3compartmentss NA 50% Human Human +DTXSID6021165 Css NA 1.104 mg/L 3compartmentss NA 95% Human Human +DTXSID6021165 Css NA 0.1312 mg/L PBTK NA 50% Human Human +DTXSID6021165 Css NA 0.7961 mg/L PBTK NA 95% Human Human DTXSID6021165 Clint NA 2.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021165 Fup NA 0.7242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021165 Vd NA 1.671 L/kg 1compartment NA NA Rat Human DTXSID6021165 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021165 TK.Half.Life NA 1.707 hours 1compartment NA NA Rat Human -DTXSID6021165 Css NA 0.06956 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021165 Css NA 0.5701 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021165 Css NA 0.06742 mg/L PBTK NA 50% Rat Human -DTXSID6021165 Css NA 0.3665 mg/L PBTK NA 95% Rat Human -DTXSID6021240 Clint NA 47.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021240 Fup NA 0.0131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021240 Vd NA 17.86 L/kg 1compartment NA NA Human Human -DTXSID6021240 Days.Css NA 48 Days PBTK NA NA Human Human -DTXSID6021240 TK.Half.Life NA 244.8 hours 1compartment NA NA Human Human -DTXSID6021240 Css NA 0.5815 mg/L 3compartmentss NA 50% Human Human -DTXSID6021240 Css NA 3.569 mg/L 3compartmentss NA 95% Human Human -DTXSID6021240 Css NA 1.104 mg/L PBTK NA 50% Human Human -DTXSID6021240 Css NA 6.498 mg/L PBTK NA 95% Human Human -DTXSID6021240 Clint NA 47.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021240 Fup NA 0.0131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021240 Vd NA 14.42 L/kg 1compartment NA NA Rat Human -DTXSID6021240 Days.Css NA 30 Days PBTK NA NA Rat Human -DTXSID6021240 TK.Half.Life NA 35.26 hours 1compartment NA NA Rat Human -DTXSID6021240 Css NA 0.3091 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021240 Css NA 1.308 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021240 Css NA 0.605 mg/L PBTK NA 50% Rat Human -DTXSID6021240 Css NA 2.595 mg/L PBTK NA 95% Rat Human +DTXSID6021165 Css NA 0.004164 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021165 Css NA 0.04181 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021165 Css NA 0.004018 mg/L PBTK NA 50% Rat Human +DTXSID6021165 Css NA 0.02989 mg/L PBTK NA 95% Rat Human +DTXSID6021240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021240 Fup 0.0204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021240 Vd NA 1650 L/kg 1compartment NA NA Human Human +DTXSID6021240 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID6021240 TK.Half.Life NA 48400 hours 1compartment NA NA Human Human +DTXSID6021240 Css NA 0.008542 mg/L 3compartmentss NA 50% Human Human +DTXSID6021240 Css NA 0.05461 mg/L 3compartmentss NA 95% Human Human +DTXSID6021240 Css NA 2.364 mg/L PBTK NA 50% Human Human +DTXSID6021240 Css NA 13.47 mg/L PBTK NA 95% Human Human +DTXSID6021240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021240 Fup 0.0204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021240 Vd NA 1523 L/kg 1compartment NA NA Rat Human +DTXSID6021240 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID6021240 TK.Half.Life NA 7633 hours 1compartment NA NA Rat Human +DTXSID6021240 Css NA 0.001007 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021240 Css NA 0.004692 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021240 Css NA 0.3074 mg/L PBTK NA 50% Rat Human +DTXSID6021240 Css NA 1.512 mg/L PBTK NA 95% Rat Human DTXSID6021244 Clint 0 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID6021244 Fup 0.04344 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID6021244 Vd NA 0.7189 L/kg 1compartment NA NA Human Human -DTXSID6021244 Days.Css NA 24 Days PBTK NA NA Human Human -DTXSID6021244 TK.Half.Life NA 115.9 hours 1compartment NA NA Human Human -DTXSID6021244 Css NA 20.77 mg/L 3compartmentss NA 50% Human Human -DTXSID6021244 Css NA 90.37 mg/L 3compartmentss NA 95% Human Human -DTXSID6021244 Css NA 12.81 mg/L PBTK NA 50% Human Human -DTXSID6021244 Css NA 53.15 mg/L PBTK NA 95% Human Human +DTXSID6021244 Vd NA 0.7572 L/kg 1compartment NA NA Human Human +DTXSID6021244 Days.Css NA 26 Days PBTK NA NA Human Human +DTXSID6021244 TK.Half.Life NA 123.2 hours 1compartment NA NA Human Human +DTXSID6021244 Css NA 15.76 mg/L 3compartmentss NA 50% Human Human +DTXSID6021244 Css NA 69.34 mg/L 3compartmentss NA 95% Human Human +DTXSID6021244 Css NA 9.792 mg/L PBTK NA 50% Human Human +DTXSID6021244 Css NA 40.71 mg/L PBTK NA 95% Human Human DTXSID6021244 Clint 0 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID6021244 Fup 0.04344 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID6021244 Vd NA 0.5543 L/kg 1compartment NA NA Rat Human -DTXSID6021244 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID6021244 TK.Half.Life NA 28.69 hours 1compartment NA NA Rat Human -DTXSID6021244 Css NA 5.857 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021244 Css NA 21.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021244 Css NA 3.396 mg/L PBTK NA 50% Rat Human -DTXSID6021244 Css NA 11.84 mg/L PBTK NA 95% Rat Human -DTXSID6021246 Clint NA 17.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021246 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021246 Vd NA 4.23 L/kg 1compartment NA NA Human Human +DTXSID6021244 Vd NA 0.5815 L/kg 1compartment NA NA Rat Human +DTXSID6021244 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID6021244 TK.Half.Life NA 30.16 hours 1compartment NA NA Rat Human +DTXSID6021244 Css NA 0.1602 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021244 Css NA 1.145 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021244 Css NA 0.09318 mg/L PBTK NA 50% Rat Human +DTXSID6021244 Css NA 0.6547 mg/L PBTK NA 95% Rat Human +DTXSID6021246 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021246 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021246 Vd NA 1.17 L/kg 1compartment NA NA Human Human DTXSID6021246 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021246 TK.Half.Life NA 3.324 hours 1compartment NA NA Human Human -DTXSID6021246 Css NA 0.02939 mg/L 3compartmentss NA 50% Human Human -DTXSID6021246 Css NA 0.2963 mg/L 3compartmentss NA 95% Human Human -DTXSID6021246 Css NA 0.03928 mg/L PBTK NA 50% Human Human -DTXSID6021246 Css NA 0.2835 mg/L PBTK NA 95% Human Human -DTXSID6021246 Clint NA 17.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021246 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021246 Vd NA 4.307 L/kg 1compartment NA NA Rat Human +DTXSID6021246 TK.Half.Life NA 5.382 hours 1compartment NA NA Human Human +DTXSID6021246 Css NA 0.5362 mg/L 3compartmentss NA 50% Human Human +DTXSID6021246 Css NA 4.11 mg/L 3compartmentss NA 95% Human Human +DTXSID6021246 Css NA 0.3843 mg/L PBTK NA 50% Human Human +DTXSID6021246 Css NA 2.618 mg/L PBTK NA 95% Human Human +DTXSID6021246 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021246 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021246 Vd NA 1.164 L/kg 1compartment NA NA Rat Human DTXSID6021246 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021246 TK.Half.Life NA 1.843 hours 1compartment NA NA Rat Human -DTXSID6021246 Css NA 0.01473 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021246 Css NA 0.1275 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021246 Css NA 0.02013 mg/L PBTK NA 50% Rat Human -DTXSID6021246 Css NA 0.1142 mg/L PBTK NA 95% Rat Human +DTXSID6021246 TK.Half.Life NA 3.239 hours 1compartment NA NA Rat Human +DTXSID6021246 Css NA 0.06468 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021246 Css NA 0.349 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021246 Css NA 0.04549 mg/L PBTK NA 50% Rat Human +DTXSID6021246 Css NA 0.2163 mg/L PBTK NA 95% Rat Human DTXSID6021248 Clint 28.31 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID6021248 Fup 0.003404 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID6021248 Vd NA 1.27 L/kg 1compartment NA NA Human Human DTXSID6021248 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID6021248 TK.Half.Life NA 30.02 hours 1compartment NA NA Human Human -DTXSID6021248 Css NA 3.536 mg/L 3compartmentss NA 50% Human Human -DTXSID6021248 Css NA 28.06 mg/L 3compartmentss NA 95% Human Human -DTXSID6021248 Css NA 2.159 mg/L PBTK NA 50% Human Human -DTXSID6021248 Css NA 17.19 mg/L PBTK NA 95% Human Human +DTXSID6021248 Css NA 3.382 mg/L 3compartmentss NA 50% Human Human +DTXSID6021248 Css NA 28.85 mg/L 3compartmentss NA 95% Human Human +DTXSID6021248 Css NA 2.066 mg/L PBTK NA 50% Human Human +DTXSID6021248 Css NA 17.06 mg/L PBTK NA 95% Human Human DTXSID6021248 Clint 28.31 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID6021248 Fup 0.003404 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID6021248 Vd NA 0.9305 L/kg 1compartment NA NA Rat Human DTXSID6021248 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID6021248 TK.Half.Life NA 12.4 hours 1compartment NA NA Rat Human -DTXSID6021248 Css NA 1.992 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021248 Css NA 13.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021248 Css NA 1.142 mg/L PBTK NA 50% Rat Human -DTXSID6021248 Css NA 7.596 mg/L PBTK NA 95% Rat Human +DTXSID6021248 Css NA 0.4492 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021248 Css NA 3.159 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021248 Css NA 0.266 mg/L PBTK NA 50% Rat Human +DTXSID6021248 Css NA 1.839 mg/L PBTK NA 95% Rat Human DTXSID6021290 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021290 Fup 0.175 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021290 Vd NA 0.3289 L/kg 1compartment NA NA Human Human DTXSID6021290 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID6021290 TK.Half.Life NA 12.17 hours 1compartment NA NA Human Human -DTXSID6021290 Css NA 4.613 mg/L 3compartmentss NA 50% Human Human -DTXSID6021290 Css NA 12.97 mg/L 3compartmentss NA 95% Human Human -DTXSID6021290 Css NA 2.946 mg/L PBTK NA 50% Human Human -DTXSID6021290 Css NA 7.933 mg/L PBTK NA 95% Human Human +DTXSID6021290 Css NA 4.436 mg/L 3compartmentss NA 50% Human Human +DTXSID6021290 Css NA 12.74 mg/L 3compartmentss NA 95% Human Human +DTXSID6021290 Css NA 2.838 mg/L PBTK NA 50% Human Human +DTXSID6021290 Css NA 7.765 mg/L PBTK NA 95% Human Human DTXSID6021290 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021290 Fup 0.175 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021290 Vd NA 0.3279 L/kg 1compartment NA NA Rat Human DTXSID6021290 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021290 TK.Half.Life NA 4.133 hours 1compartment NA NA Rat Human -DTXSID6021290 Css NA 1.281 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021290 Css NA 2.826 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021290 Css NA 0.7728 mg/L PBTK NA 50% Rat Human -DTXSID6021290 Css NA 1.612 mg/L PBTK NA 95% Rat Human -DTXSID6021292 Clint NA 6.975 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6021290 Css NA 0.2882 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021290 Css NA 0.6425 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021290 Css NA 0.18 mg/L PBTK NA 50% Rat Human +DTXSID6021290 Css NA 0.379 mg/L PBTK NA 95% Rat Human +DTXSID6021292 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6021292 Fup 0.079 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6021292 Vd NA 0.2388 L/kg 1compartment NA NA Human Human DTXSID6021292 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021292 TK.Half.Life NA 1.729 hours 1compartment NA NA Human Human -DTXSID6021292 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID6021292 Css NA 7.922 mg/L 3compartmentss NA 95% Human Human -DTXSID6021292 Css NA 0.6924 mg/L PBTK NA 50% Human Human -DTXSID6021292 Css NA 4.725 mg/L PBTK NA 95% Human Human -DTXSID6021292 Clint NA 6.975 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6021292 TK.Half.Life NA 1.889 hours 1compartment NA NA Human Human +DTXSID6021292 Css NA 1.209 mg/L 3compartmentss NA 50% Human Human +DTXSID6021292 Css NA 8.375 mg/L 3compartmentss NA 95% Human Human +DTXSID6021292 Css NA 0.7358 mg/L PBTK NA 50% Human Human +DTXSID6021292 Css NA 4.921 mg/L PBTK NA 95% Human Human +DTXSID6021292 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6021292 Fup 0.079 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6021292 Vd NA 0.2381 L/kg 1compartment NA NA Rat Human DTXSID6021292 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021292 TK.Half.Life NA 1.065 hours 1compartment NA NA Rat Human -DTXSID6021292 Css NA 0.6098 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021292 Css NA 3.062 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021292 Css NA 0.3461 mg/L PBTK NA 50% Rat Human -DTXSID6021292 Css NA 1.695 mg/L PBTK NA 95% Rat Human +DTXSID6021292 TK.Half.Life NA 1.16 hours 1compartment NA NA Rat Human +DTXSID6021292 Css NA 0.1511 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021292 Css NA 0.7395 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021292 Css NA 0.08833 mg/L PBTK NA 50% Rat Human +DTXSID6021292 Css NA 0.4218 mg/L PBTK NA 95% Rat Human DTXSID6021294 Clint NA 3.329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021294 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021294 Vd NA 0.8613 L/kg 1compartment NA NA Human Human +DTXSID6021294 Vd NA 1.373 L/kg 1compartment NA NA Human Human DTXSID6021294 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021294 TK.Half.Life NA 1.198 hours 1compartment NA NA Human Human -DTXSID6021294 Css NA 0.13 mg/L 3compartmentss NA 50% Human Human -DTXSID6021294 Css NA 1.048 mg/L 3compartmentss NA 95% Human Human -DTXSID6021294 Css NA 0.1105 mg/L PBTK NA 50% Human Human -DTXSID6021294 Css NA 0.7539 mg/L PBTK NA 95% Human Human +DTXSID6021294 TK.Half.Life NA 1.944 hours 1compartment NA NA Human Human +DTXSID6021294 Css NA 0.09844 mg/L 3compartmentss NA 50% Human Human +DTXSID6021294 Css NA 0.8528 mg/L 3compartmentss NA 95% Human Human +DTXSID6021294 Css NA 0.09188 mg/L PBTK NA 50% Human Human +DTXSID6021294 Css NA 0.6444 mg/L PBTK NA 95% Human Human DTXSID6021294 Clint NA 3.329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021294 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021294 Vd NA 0.8873 L/kg 1compartment NA NA Rat Human +DTXSID6021294 Vd NA 1.286 L/kg 1compartment NA NA Rat Human DTXSID6021294 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021294 TK.Half.Life NA 0.6454 hours 1compartment NA NA Rat Human -DTXSID6021294 Css NA 0.05773 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021294 Css NA 0.3844 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021294 Css NA 0.04888 mg/L PBTK NA 50% Rat Human -DTXSID6021294 Css NA 0.2425 mg/L PBTK NA 95% Rat Human -DTXSID6021296 Clint NA 5.317 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021296 Fup NA 0.041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021296 Vd NA 0.5812 L/kg 1compartment NA NA Human Human +DTXSID6021294 TK.Half.Life NA 0.9265 hours 1compartment NA NA Rat Human +DTXSID6021294 Css NA 0.002997 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021294 Css NA 0.03112 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021294 Css NA 0.002784 mg/L PBTK NA 50% Rat Human +DTXSID6021294 Css NA 0.02236 mg/L PBTK NA 95% Rat Human +DTXSID6021296 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021296 Fup 0.0531 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021296 Vd NA 0.721 L/kg 1compartment NA NA Human Human DTXSID6021296 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021296 TK.Half.Life NA 9.447 hours 1compartment NA NA Human Human -DTXSID6021296 Css NA 2.822 mg/L 3compartmentss NA 50% Human Human -DTXSID6021296 Css NA 21.97 mg/L 3compartmentss NA 95% Human Human -DTXSID6021296 Css NA 1.768 mg/L PBTK NA 50% Human Human -DTXSID6021296 Css NA 13.08 mg/L PBTK NA 95% Human Human -DTXSID6021296 Clint NA 5.317 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021296 Fup NA 0.041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021296 Vd NA 0.4738 L/kg 1compartment NA NA Rat Human +DTXSID6021296 TK.Half.Life NA 8.102 hours 1compartment NA NA Human Human +DTXSID6021296 Css NA 1.52 mg/L 3compartmentss NA 50% Human Human +DTXSID6021296 Css NA 10.96 mg/L 3compartmentss NA 95% Human Human +DTXSID6021296 Css NA 0.972 mg/L PBTK NA 50% Human Human +DTXSID6021296 Css NA 6.612 mg/L PBTK NA 95% Human Human +DTXSID6021296 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021296 Fup 0.0531 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021296 Vd NA 0.5814 L/kg 1compartment NA NA Rat Human DTXSID6021296 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021296 TK.Half.Life NA 4.671 hours 1compartment NA NA Rat Human -DTXSID6021296 Css NA 1.466 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021296 Css NA 8.908 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021296 Css NA 0.8561 mg/L PBTK NA 50% Rat Human -DTXSID6021296 Css NA 4.92 mg/L PBTK NA 95% Rat Human -DTXSID6021321 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021321 Fup NA 0.4256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021321 Vd NA 0.8725 L/kg 1compartment NA NA Human Human -DTXSID6021321 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6021321 TK.Half.Life NA 13.26 hours 1compartment NA NA Human Human -DTXSID6021321 Css NA 1.626 mg/L 3compartmentss NA 50% Human Human -DTXSID6021321 Css NA 7.63 mg/L 3compartmentss NA 95% Human Human -DTXSID6021321 Css NA 1.266 mg/L PBTK NA 50% Human Human -DTXSID6021321 Css NA 4.941 mg/L PBTK NA 95% Human Human -DTXSID6021321 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021321 Fup NA 0.4256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021321 Vd NA 0.891 L/kg 1compartment NA NA Rat Human +DTXSID6021296 TK.Half.Life NA 3.909 hours 1compartment NA NA Rat Human +DTXSID6021296 Css NA 0.0702 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021296 Css NA 0.584 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021296 Css NA 0.04334 mg/L PBTK NA 50% Rat Human +DTXSID6021296 Css NA 0.342 mg/L PBTK NA 95% Rat Human +DTXSID6021321 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021321 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021321 Vd NA 0.4396 L/kg 1compartment NA NA Human Human +DTXSID6021321 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6021321 TK.Half.Life NA 6.957 hours 1compartment NA NA Human Human +DTXSID6021321 Css NA 0.9902 mg/L 3compartmentss NA 50% Human Human +DTXSID6021321 Css NA 4.603 mg/L 3compartmentss NA 95% Human Human +DTXSID6021321 Css NA 0.7055 mg/L PBTK NA 50% Human Human +DTXSID6021321 Css NA 2.85 mg/L PBTK NA 95% Human Human +DTXSID6021321 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021321 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021321 Vd NA 0.4523 L/kg 1compartment NA NA Rat Human DTXSID6021321 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021321 TK.Half.Life NA 4.615 hours 1compartment NA NA Rat Human -DTXSID6021321 Css NA 0.4344 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021321 Css NA 1.756 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021321 Css NA 0.3275 mg/L PBTK NA 50% Rat Human -DTXSID6021321 Css NA 1.064 mg/L PBTK NA 95% Rat Human -DTXSID6021327 Clint NA 95.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6021321 TK.Half.Life NA 2.438 hours 1compartment NA NA Rat Human +DTXSID6021321 Css NA 0.0054 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021321 Css NA 0.02558 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021321 Css NA 0.00363 mg/L PBTK NA 50% Rat Human +DTXSID6021321 Css NA 0.01528 mg/L PBTK NA 95% Rat Human +DTXSID6021327 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6021327 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6021327 Vd NA 20.99 L/kg 1compartment NA NA Human Human -DTXSID6021327 Days.Css NA 28 Days PBTK NA NA Human Human -DTXSID6021327 TK.Half.Life NA 156.1 hours 1compartment NA NA Human Human -DTXSID6021327 Css NA 0.9537 mg/L 3compartmentss NA 50% Human Human -DTXSID6021327 Css NA 5.619 mg/L 3compartmentss NA 95% Human Human -DTXSID6021327 Css NA 0.5519 mg/L PBTK NA 50% Human Human -DTXSID6021327 Css NA 3.233 mg/L PBTK NA 95% Human Human -DTXSID6021327 Clint NA 95.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6021327 Days.Css NA 146 Days PBTK NA NA Human Human +DTXSID6021327 TK.Half.Life NA 614.5 hours 1compartment NA NA Human Human +DTXSID6021327 Css NA 4.256 mg/L 3compartmentss NA 50% Human Human +DTXSID6021327 Css NA 25.93 mg/L 3compartmentss NA 95% Human Human +DTXSID6021327 Css NA 2.34 mg/L PBTK NA 50% Human Human +DTXSID6021327 Css NA 14.26 mg/L PBTK NA 95% Human Human +DTXSID6021327 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6021327 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6021327 Vd NA 17.07 L/kg 1compartment NA NA Rat Human -DTXSID6021327 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID6021327 TK.Half.Life NA 26.17 hours 1compartment NA NA Rat Human -DTXSID6021327 Css NA 0.5492 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021327 Css NA 2.483 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021327 Css NA 0.2966 mg/L PBTK NA 50% Rat Human -DTXSID6021327 Css NA 1.341 mg/L PBTK NA 95% Rat Human -DTXSID6021371 Clint NA 29.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6021327 Days.Css NA 83 Days PBTK NA NA Rat Human +DTXSID6021327 TK.Half.Life NA 89.3 hours 1compartment NA NA Rat Human +DTXSID6021327 Css NA 0.5342 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021327 Css NA 2.811 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021327 Css NA 0.3041 mg/L PBTK NA 50% Rat Human +DTXSID6021327 Css NA 1.601 mg/L PBTK NA 95% Rat Human +DTXSID6021371 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID6021371 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6021371 Vd NA 0.6994 L/kg 1compartment NA NA Human Human +DTXSID6021371 Vd NA 0.6937 L/kg 1compartment NA NA Human Human DTXSID6021371 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021371 TK.Half.Life NA 1.001 hours 1compartment NA NA Human Human -DTXSID6021371 Css NA 0.08245 mg/L 3compartmentss NA 50% Human Human -DTXSID6021371 Css NA 0.5721 mg/L 3compartmentss NA 95% Human Human -DTXSID6021371 Css NA 0.05648 mg/L PBTK NA 50% Human Human -DTXSID6021371 Css NA 0.365 mg/L PBTK NA 95% Human Human -DTXSID6021371 Clint NA 29.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6021371 TK.Half.Life NA 1.926 hours 1compartment NA NA Human Human +DTXSID6021371 Css NA 0.2543 mg/L 3compartmentss NA 50% Human Human +DTXSID6021371 Css NA 1.583 mg/L 3compartmentss NA 95% Human Human +DTXSID6021371 Css NA 0.173 mg/L PBTK NA 50% Human Human +DTXSID6021371 Css NA 1.024 mg/L PBTK NA 95% Human Human +DTXSID6021371 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID6021371 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6021371 Vd NA 0.5929 L/kg 1compartment NA NA Rat Human +DTXSID6021371 Vd NA 0.5889 L/kg 1compartment NA NA Rat Human DTXSID6021371 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021371 TK.Half.Life NA 0.4489 hours 1compartment NA NA Rat Human -DTXSID6021371 Css NA 0.0457 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021371 Css NA 0.2463 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021371 Css NA 0.02984 mg/L PBTK NA 50% Rat Human -DTXSID6021371 Css NA 0.1512 mg/L PBTK NA 95% Rat Human +DTXSID6021371 TK.Half.Life NA 0.9339 hours 1compartment NA NA Rat Human +DTXSID6021371 Css NA 0.03076 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021371 Css NA 0.1419 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021371 Css NA 0.02078 mg/L PBTK NA 50% Rat Human +DTXSID6021371 Css NA 0.08918 mg/L PBTK NA 95% Rat Human DTXSID6021373 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021373 Fup 0.333 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021373 Vd NA 0.8436 L/kg 1compartment NA NA Human Human DTXSID6021373 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID6021373 TK.Half.Life NA 16.73 hours 1compartment NA NA Human Human -DTXSID6021373 Css NA 2.102 mg/L 3compartmentss NA 50% Human Human -DTXSID6021373 Css NA 6.63 mg/L 3compartmentss NA 95% Human Human -DTXSID6021373 Css NA 1.584 mg/L PBTK NA 50% Human Human -DTXSID6021373 Css NA 4.438 mg/L PBTK NA 95% Human Human +DTXSID6021373 Css NA 2.046 mg/L 3compartmentss NA 50% Human Human +DTXSID6021373 Css NA 6.525 mg/L 3compartmentss NA 95% Human Human +DTXSID6021373 Css NA 1.542 mg/L PBTK NA 50% Human Human +DTXSID6021373 Css NA 4.363 mg/L PBTK NA 95% Human Human DTXSID6021373 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021373 Fup 0.333 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021373 Vd NA 0.8021 L/kg 1compartment NA NA Rat Human DTXSID6021373 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021373 TK.Half.Life NA 5.336 hours 1compartment NA NA Rat Human -DTXSID6021373 Css NA 0.5752 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021373 Css NA 1.455 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021373 Css NA 0.4161 mg/L PBTK NA 50% Rat Human -DTXSID6021373 Css NA 0.9078 mg/L PBTK NA 95% Rat Human -DTXSID6021375 Clint NA 211.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021375 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021375 Vd NA 6.507 L/kg 1compartment NA NA Human Human -DTXSID6021375 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6021375 TK.Half.Life NA 23.73 hours 1compartment NA NA Human Human -DTXSID6021375 Css NA 0.2774 mg/L 3compartmentss NA 50% Human Human -DTXSID6021375 Css NA 1.564 mg/L 3compartmentss NA 95% Human Human -DTXSID6021375 Css NA 0.2531 mg/L PBTK NA 50% Human Human -DTXSID6021375 Css NA 1.379 mg/L PBTK NA 95% Human Human -DTXSID6021375 Clint NA 211.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021375 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021375 Vd NA 5.026 L/kg 1compartment NA NA Rat Human -DTXSID6021375 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6021375 TK.Half.Life NA 4.03 hours 1compartment NA NA Rat Human -DTXSID6021375 Css NA 0.1526 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021375 Css NA 0.6737 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021375 Css NA 0.1367 mg/L PBTK NA 50% Rat Human -DTXSID6021375 Css NA 0.6193 mg/L PBTK NA 95% Rat Human -DTXSID6021379 Clint NA 27.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021379 Fup NA 0.0932 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021379 Vd NA 2.527 L/kg 1compartment NA NA Human Human -DTXSID6021379 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021379 TK.Half.Life NA 9.94 hours 1compartment NA NA Human Human -DTXSID6021379 Css NA 0.4436 mg/L 3compartmentss NA 50% Human Human -DTXSID6021379 Css NA 2.899 mg/L 3compartmentss NA 95% Human Human -DTXSID6021379 Css NA 0.303 mg/L PBTK NA 50% Human Human -DTXSID6021379 Css NA 1.927 mg/L PBTK NA 95% Human Human -DTXSID6021379 Clint NA 27.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021379 Fup NA 0.0932 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021379 Vd NA 1.903 L/kg 1compartment NA NA Rat Human +DTXSID6021373 Css NA 0.1303 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021373 Css NA 0.3249 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021373 Css NA 0.09757 mg/L PBTK NA 50% Rat Human +DTXSID6021373 Css NA 0.2104 mg/L PBTK NA 95% Rat Human +DTXSID6021375 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021375 Fup 0.0533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021375 Vd NA 9.586 L/kg 1compartment NA NA Human Human +DTXSID6021375 Days.Css NA 58 Days PBTK NA NA Human Human +DTXSID6021375 TK.Half.Life NA 284.5 hours 1compartment NA NA Human Human +DTXSID6021375 Css NA 2.034 mg/L 3compartmentss NA 50% Human Human +DTXSID6021375 Css NA 11.97 mg/L 3compartmentss NA 95% Human Human +DTXSID6021375 Css NA 2.36 mg/L PBTK NA 50% Human Human +DTXSID6021375 Css NA 13.33 mg/L PBTK NA 95% Human Human +DTXSID6021375 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021375 Fup 0.0533 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021375 Vd NA 7.532 L/kg 1compartment NA NA Rat Human +DTXSID6021375 Days.Css NA 35 Days PBTK NA NA Rat Human +DTXSID6021375 TK.Half.Life NA 38.68 hours 1compartment NA NA Rat Human +DTXSID6021375 Css NA 0.2549 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021375 Css NA 1.212 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021375 Css NA 0.3061 mg/L PBTK NA 50% Rat Human +DTXSID6021375 Css NA 1.509 mg/L PBTK NA 95% Rat Human +DTXSID6021379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021379 Fup 0.0266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021379 Vd NA 1.751 L/kg 1compartment NA NA Human Human +DTXSID6021379 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6021379 TK.Half.Life NA 13.79 hours 1compartment NA NA Human Human +DTXSID6021379 Css NA 1.159 mg/L 3compartmentss NA 50% Human Human +DTXSID6021379 Css NA 10.23 mg/L 3compartmentss NA 95% Human Human +DTXSID6021379 Css NA 0.7406 mg/L PBTK NA 50% Human Human +DTXSID6021379 Css NA 6.25 mg/L PBTK NA 95% Human Human +DTXSID6021379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021379 Fup 0.0266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021379 Vd NA 1.303 L/kg 1compartment NA NA Rat Human DTXSID6021379 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021379 TK.Half.Life NA 2.594 hours 1compartment NA NA Rat Human -DTXSID6021379 Css NA 0.2452 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021379 Css NA 1.273 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021379 Css NA 0.16 mg/L PBTK NA 50% Rat Human -DTXSID6021379 Css NA 0.8025 mg/L PBTK NA 95% Rat Human -DTXSID6021404 Clint NA 10.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021404 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021404 Vd NA 0.9819 L/kg 1compartment NA NA Human Human +DTXSID6021379 TK.Half.Life NA 4.899 hours 1compartment NA NA Rat Human +DTXSID6021379 Css NA 0.1504 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021379 Css NA 0.9954 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021379 Css NA 0.09354 mg/L PBTK NA 50% Rat Human +DTXSID6021379 Css NA 0.5898 mg/L PBTK NA 95% Rat Human +DTXSID6021404 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021404 Fup 0.646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021404 Vd NA 0.752 L/kg 1compartment NA NA Human Human DTXSID6021404 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021404 TK.Half.Life NA 0.8047 hours 1compartment NA NA Human Human -DTXSID6021404 Css NA 0.04426 mg/L 3compartmentss NA 50% Human Human -DTXSID6021404 Css NA 0.496 mg/L 3compartmentss NA 95% Human Human -DTXSID6021404 Css NA 0.03846 mg/L PBTK NA 50% Human Human -DTXSID6021404 Css NA 0.3688 mg/L PBTK NA 95% Human Human -DTXSID6021404 Clint NA 10.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021404 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021404 Vd NA 0.9898 L/kg 1compartment NA NA Rat Human +DTXSID6021404 TK.Half.Life NA 7.576 hours 1compartment NA NA Human Human +DTXSID6021404 Css NA 0.9693 mg/L 3compartmentss NA 50% Human Human +DTXSID6021404 Css NA 6.201 mg/L 3compartmentss NA 95% Human Human +DTXSID6021404 Css NA 0.7934 mg/L PBTK NA 50% Human Human +DTXSID6021404 Css NA 3.957 mg/L PBTK NA 95% Human Human +DTXSID6021404 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021404 Fup 0.646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021404 Vd NA 0.7562 L/kg 1compartment NA NA Rat Human DTXSID6021404 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021404 TK.Half.Life NA 0.4068 hours 1compartment NA NA Rat Human -DTXSID6021404 Css NA 0.02139 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021404 Css NA 0.1849 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021404 Css NA 0.01862 mg/L PBTK NA 50% Rat Human -DTXSID6021404 Css NA 0.1279 mg/L PBTK NA 95% Rat Human -DTXSID6021408 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021408 Fup NA 0.0075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021408 Vd NA 3.047 L/kg 1compartment NA NA Human Human -DTXSID6021408 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6021408 TK.Half.Life NA 58590 hours 1compartment NA NA Human Human -DTXSID6021408 Css NA 2270 mg/L 3compartmentss NA 50% Human Human -DTXSID6021408 Css NA 6297 mg/L 3compartmentss NA 95% Human Human -DTXSID6021408 Css NA 1570 mg/L PBTK NA 50% Human Human -DTXSID6021408 Css NA 4037 mg/L PBTK NA 95% Human Human -DTXSID6021408 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021408 Fup NA 0.0075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021408 Vd NA 2.28 L/kg 1compartment NA NA Rat Human -DTXSID6021408 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6021408 TK.Half.Life NA 4075 hours 1compartment NA NA Rat Human -DTXSID6021408 Css NA 621.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021408 Css NA 1426 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021408 Css NA 408.7 mg/L PBTK NA 50% Rat Human -DTXSID6021408 Css NA 850.8 mg/L PBTK NA 95% Rat Human -DTXSID6021450 Clint NA 36.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021450 Fup NA 0.0296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021450 Vd NA 0.854 L/kg 1compartment NA NA Human Human +DTXSID6021404 TK.Half.Life NA 2.584 hours 1compartment NA NA Rat Human +DTXSID6021404 Css NA 0.01854 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021404 Css NA 0.1525 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021404 Css NA 0.01437 mg/L PBTK NA 50% Rat Human +DTXSID6021404 Css NA 0.09809 mg/L PBTK NA 95% Rat Human +DTXSID6021450 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021450 Fup 0.0318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021450 Vd NA 1.368 L/kg 1compartment NA NA Human Human DTXSID6021450 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021450 TK.Half.Life NA 3.597 hours 1compartment NA NA Human Human -DTXSID6021450 Css NA 0.6112 mg/L 3compartmentss NA 50% Human Human -DTXSID6021450 Css NA 5.827 mg/L 3compartmentss NA 95% Human Human -DTXSID6021450 Css NA 0.3748 mg/L PBTK NA 50% Human Human -DTXSID6021450 Css NA 3.402 mg/L PBTK NA 95% Human Human -DTXSID6021450 Clint NA 36.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021450 Fup NA 0.0296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021450 Vd NA 0.6468 L/kg 1compartment NA NA Rat Human +DTXSID6021450 TK.Half.Life NA 8.78 hours 1compartment NA NA Human Human +DTXSID6021450 Css NA 0.9544 mg/L 3compartmentss NA 50% Human Human +DTXSID6021450 Css NA 8.638 mg/L 3compartmentss NA 95% Human Human +DTXSID6021450 Css NA 0.6 mg/L PBTK NA 50% Human Human +DTXSID6021450 Css NA 5.187 mg/L PBTK NA 95% Human Human +DTXSID6021450 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021450 Fup 0.0318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021450 Vd NA 1.022 L/kg 1compartment NA NA Rat Human DTXSID6021450 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021450 TK.Half.Life NA 1.607 hours 1compartment NA NA Rat Human -DTXSID6021450 Css NA 0.3459 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021450 Css NA 2.824 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021450 Css NA 0.1972 mg/L PBTK NA 50% Rat Human -DTXSID6021450 Css NA 1.566 mg/L PBTK NA 95% Rat Human +DTXSID6021450 TK.Half.Life NA 3.511 hours 1compartment NA NA Rat Human +DTXSID6021450 Css NA 0.1238 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021450 Css NA 0.893 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021450 Css NA 0.07532 mg/L PBTK NA 50% Rat Human +DTXSID6021450 Css NA 0.5177 mg/L PBTK NA 95% Rat Human DTXSID6021456 Clint 18.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021456 Fup 1.38e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6021456 Vd NA 0.1592 L/kg 1compartment NA NA Human Human -DTXSID6021456 Days.Css NA 79 Days PBTK NA NA Human Human -DTXSID6021456 TK.Half.Life NA 318.4 hours 1compartment NA NA Human Human -DTXSID6021456 Css NA 1.878 mg/L 3compartmentss NA 50% Human Human -DTXSID6021456 Css NA 50.24 mg/L 3compartmentss NA 95% Human Human -DTXSID6021456 Css NA 1.107 mg/L PBTK NA 50% Human Human -DTXSID6021456 Css NA 29.15 mg/L PBTK NA 95% Human Human +DTXSID6021456 Vd NA 0.1591 L/kg 1compartment NA NA Human Human +DTXSID6021456 Days.Css NA 77 Days PBTK NA NA Human Human +DTXSID6021456 TK.Half.Life NA 313.8 hours 1compartment NA NA Human Human +DTXSID6021456 Css NA 0.9756 mg/L 3compartmentss NA 50% Human Human +DTXSID6021456 Css NA 28.63 mg/L 3compartmentss NA 95% Human Human +DTXSID6021456 Css NA 0.5701 mg/L PBTK NA 50% Human Human +DTXSID6021456 Css NA 16.41 mg/L PBTK NA 95% Human Human DTXSID6021456 Clint 18.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021456 Fup 1.38e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6021456 Vd NA 0.1578 L/kg 1compartment NA NA Rat Human +DTXSID6021456 Vd NA 0.1577 L/kg 1compartment NA NA Rat Human DTXSID6021456 Days.Css NA 51 Days PBTK NA NA Rat Human -DTXSID6021456 TK.Half.Life NA 214.5 hours 1compartment NA NA Rat Human -DTXSID6021456 Css NA 1.187 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021456 Css NA 22.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021456 Css NA 0.6471 mg/L PBTK NA 50% Rat Human -DTXSID6021456 Css NA 12.01 mg/L PBTK NA 95% Rat Human -DTXSID6021458 Clint NA 8.533 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021458 Fup NA 0.5235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021458 Vd NA 1.117 L/kg 1compartment NA NA Human Human -DTXSID6021458 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021458 TK.Half.Life NA 1.585 hours 1compartment NA NA Human Human -DTXSID6021458 Css NA 0.09562 mg/L 3compartmentss NA 50% Human Human -DTXSID6021458 Css NA 0.7719 mg/L 3compartmentss NA 95% Human Human -DTXSID6021458 Css NA 0.07854 mg/L PBTK NA 50% Human Human -DTXSID6021458 Css NA 0.5368 mg/L PBTK NA 95% Human Human -DTXSID6021458 Clint NA 8.533 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021458 Fup NA 0.5235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021458 Vd NA 1.002 L/kg 1compartment NA NA Rat Human +DTXSID6021456 TK.Half.Life NA 211.6 hours 1compartment NA NA Rat Human +DTXSID6021456 Css NA 0.01123 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021456 Css NA 0.262 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021456 Css NA 0.006119 mg/L PBTK NA 50% Rat Human +DTXSID6021456 Css NA 0.142 mg/L PBTK NA 95% Rat Human +DTXSID6021458 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021458 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021458 Vd NA 1.282 L/kg 1compartment NA NA Human Human +DTXSID6021458 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6021458 TK.Half.Life NA 24.84 hours 1compartment NA NA Human Human +DTXSID6021458 Css NA 1.986 mg/L 3compartmentss NA 50% Human Human +DTXSID6021458 Css NA 8.099 mg/L 3compartmentss NA 95% Human Human +DTXSID6021458 Css NA 1.572 mg/L PBTK NA 50% Human Human +DTXSID6021458 Css NA 5.376 mg/L PBTK NA 95% Human Human +DTXSID6021458 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021458 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021458 Vd NA 1.084 L/kg 1compartment NA NA Rat Human DTXSID6021458 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021458 TK.Half.Life NA 0.7472 hours 1compartment NA NA Rat Human -DTXSID6021458 Css NA 0.04762 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021458 Css NA 0.3403 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021458 Css NA 0.03825 mg/L PBTK NA 50% Rat Human -DTXSID6021458 Css NA 0.2174 mg/L PBTK NA 95% Rat Human -DTXSID6021581 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021581 Fup NA 0.5628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021581 Vd NA 0.5374 L/kg 1compartment NA NA Human Human +DTXSID6021458 TK.Half.Life NA 6.412 hours 1compartment NA NA Rat Human +DTXSID6021458 Css NA 0.124 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021458 Css NA 0.443 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021458 Css NA 0.09774 mg/L PBTK NA 50% Rat Human +DTXSID6021458 Css NA 0.2828 mg/L PBTK NA 95% Rat Human +DTXSID6021581 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021581 Fup 0.867 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021581 Vd NA 0.6972 L/kg 1compartment NA NA Human Human DTXSID6021581 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021581 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human -DTXSID6021581 Css NA 1.346 mg/L 3compartmentss NA 50% Human Human -DTXSID6021581 Css NA 9.114 mg/L 3compartmentss NA 95% Human Human -DTXSID6021581 Css NA 1.034 mg/L PBTK NA 50% Human Human -DTXSID6021581 Css NA 5.663 mg/L PBTK NA 95% Human Human -DTXSID6021581 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021581 Fup NA 0.5628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021581 Vd NA 0.5506 L/kg 1compartment NA NA Rat Human +DTXSID6021581 TK.Half.Life NA 5.204 hours 1compartment NA NA Human Human +DTXSID6021581 Css NA 0.8071 mg/L 3compartmentss NA 50% Human Human +DTXSID6021581 Css NA 4.574 mg/L 3compartmentss NA 95% Human Human +DTXSID6021581 Css NA 0.6686 mg/L PBTK NA 50% Human Human +DTXSID6021581 Css NA 3.003 mg/L PBTK NA 95% Human Human +DTXSID6021581 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021581 Fup 0.867 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021581 Vd NA 0.7153 L/kg 1compartment NA NA Rat Human DTXSID6021581 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021581 TK.Half.Life NA 2.157 hours 1compartment NA NA Rat Human -DTXSID6021581 Css NA 0.3538 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021581 Css NA 2.274 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021581 Css NA 0.2603 mg/L PBTK NA 50% Rat Human -DTXSID6021581 Css NA 1.316 mg/L PBTK NA 95% Rat Human +DTXSID6021581 TK.Half.Life NA 1.819 hours 1compartment NA NA Rat Human +DTXSID6021581 Css NA 0.01492 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021581 Css NA 0.11 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021581 Css NA 0.01195 mg/L PBTK NA 50% Rat Human +DTXSID6021581 Css NA 0.072 mg/L PBTK NA 95% Rat Human DTXSID6021583 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021583 Fup NA 0.9135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021583 Vd NA 0.7187 L/kg 1compartment NA NA Human Human DTXSID6021583 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6021583 TK.Half.Life NA 5.093 hours 1compartment NA NA Human Human -DTXSID6021583 Css NA 0.8934 mg/L 3compartmentss NA 50% Human Human -DTXSID6021583 Css NA 3.37 mg/L 3compartmentss NA 95% Human Human -DTXSID6021583 Css NA 0.7345 mg/L PBTK NA 50% Human Human -DTXSID6021583 Css NA 2.331 mg/L PBTK NA 95% Human Human +DTXSID6021583 Css NA 0.7548 mg/L 3compartmentss NA 50% Human Human +DTXSID6021583 Css NA 2.904 mg/L 3compartmentss NA 95% Human Human +DTXSID6021583 Css NA 0.6218 mg/L PBTK NA 50% Human Human +DTXSID6021583 Css NA 2.021 mg/L PBTK NA 95% Human Human DTXSID6021583 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021583 Fup NA 0.9135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021583 Vd NA 0.7568 L/kg 1compartment NA NA Rat Human DTXSID6021583 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021583 TK.Half.Life NA 1.826 hours 1compartment NA NA Rat Human -DTXSID6021583 Css NA 0.2294 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021583 Css NA 0.8083 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021583 Css NA 0.1844 mg/L PBTK NA 50% Rat Human -DTXSID6021583 Css NA 0.5131 mg/L PBTK NA 95% Rat Human +DTXSID6021583 Css NA 0.01346 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021583 Css NA 0.07511 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021583 Css NA 0.0107 mg/L PBTK NA 50% Rat Human +DTXSID6021583 Css NA 0.05332 mg/L PBTK NA 95% Rat Human DTXSID6021585 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021585 Fup NA 0.5118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021585 Vd NA 0.5362 L/kg 1compartment NA NA Human Human DTXSID6021585 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6021585 TK.Half.Life NA 6.776 hours 1compartment NA NA Human Human -DTXSID6021585 Css NA 1.444 mg/L 3compartmentss NA 50% Human Human -DTXSID6021585 Css NA 7.547 mg/L 3compartmentss NA 95% Human Human -DTXSID6021585 Css NA 1.104 mg/L PBTK NA 50% Human Human -DTXSID6021585 Css NA 4.783 mg/L PBTK NA 95% Human Human +DTXSID6021585 Css NA 1.204 mg/L 3compartmentss NA 50% Human Human +DTXSID6021585 Css NA 6.587 mg/L 3compartmentss NA 95% Human Human +DTXSID6021585 Css NA 0.923 mg/L PBTK NA 50% Human Human +DTXSID6021585 Css NA 4.211 mg/L PBTK NA 95% Human Human DTXSID6021585 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021585 Fup NA 0.5118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021585 Vd NA 0.5458 L/kg 1compartment NA NA Rat Human DTXSID6021585 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021585 TK.Half.Life NA 2.351 hours 1compartment NA NA Rat Human -DTXSID6021585 Css NA 0.3823 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021585 Css NA 1.82 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021585 Css NA 0.2801 mg/L PBTK NA 50% Rat Human -DTXSID6021585 Css NA 1.074 mg/L PBTK NA 95% Rat Human -DTXSID6021610 Clint NA 0.07489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021610 Fup NA 0.1793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021610 Vd NA 0.3432 L/kg 1compartment NA NA Human Human -DTXSID6021610 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6021610 TK.Half.Life NA 11.02 hours 1compartment NA NA Human Human -DTXSID6021610 Css NA 3.939 mg/L 3compartmentss NA 50% Human Human -DTXSID6021610 Css NA 14.19 mg/L 3compartmentss NA 95% Human Human -DTXSID6021610 Css NA 2.584 mg/L PBTK NA 50% Human Human -DTXSID6021610 Css NA 8.656 mg/L PBTK NA 95% Human Human -DTXSID6021610 Clint NA 0.07489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021610 Fup NA 0.1793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021610 Vd NA 0.3419 L/kg 1compartment NA NA Rat Human +DTXSID6021585 Css NA 0.02276 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021585 Css NA 0.1672 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021585 Css NA 0.01692 mg/L PBTK NA 50% Rat Human +DTXSID6021585 Css NA 0.1051 mg/L PBTK NA 95% Rat Human +DTXSID6021610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021610 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021610 Vd NA 0.5313 L/kg 1compartment NA NA Human Human +DTXSID6021610 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6021610 TK.Half.Life NA 0.5724 hours 1compartment NA NA Human Human +DTXSID6021610 Css NA 0.04414 mg/L 3compartmentss NA 50% Human Human +DTXSID6021610 Css NA 0.367 mg/L 3compartmentss NA 95% Human Human +DTXSID6021610 Css NA 0.03318 mg/L PBTK NA 50% Human Human +DTXSID6021610 Css NA 0.2539 mg/L PBTK NA 95% Human Human +DTXSID6021610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021610 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021610 Vd NA 0.5331 L/kg 1compartment NA NA Rat Human DTXSID6021610 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021610 TK.Half.Life NA 3.965 hours 1compartment NA NA Rat Human -DTXSID6021610 Css NA 1.169 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021610 Css NA 3.534 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021610 Css NA 0.724 mg/L PBTK NA 50% Rat Human -DTXSID6021610 Css NA 2.011 mg/L PBTK NA 95% Rat Human -DTXSID6021618 Clint NA 0.06822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021618 Fup NA 0.0986 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021618 Vd NA 0.3134 L/kg 1compartment NA NA Human Human -DTXSID6021618 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6021618 TK.Half.Life NA 18.49 hours 1compartment NA NA Human Human -DTXSID6021618 Css NA 8.912 mg/L 3compartmentss NA 50% Human Human -DTXSID6021618 Css NA 42.95 mg/L 3compartmentss NA 95% Human Human -DTXSID6021618 Css NA 5.614 mg/L PBTK NA 50% Human Human -DTXSID6021618 Css NA 25.49 mg/L PBTK NA 95% Human Human -DTXSID6021618 Clint NA 0.06822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021618 Fup NA 0.0986 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021618 Vd NA 0.308 L/kg 1compartment NA NA Rat Human +DTXSID6021610 TK.Half.Life NA 0.2945 hours 1compartment NA NA Rat Human +DTXSID6021610 Css NA 0.005533 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021610 Css NA 0.03585 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021610 Css NA 0.004164 mg/L PBTK NA 50% Rat Human +DTXSID6021610 Css NA 0.02418 mg/L PBTK NA 95% Rat Human +DTXSID6021616 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021616 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021616 Vd NA 1.098 L/kg 1compartment NA NA Human Human +DTXSID6021616 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6021616 TK.Half.Life NA 10.52 hours 1compartment NA NA Human Human +DTXSID6021616 Css NA 1.012 mg/L 3compartmentss NA 50% Human Human +DTXSID6021616 Css NA 6.735 mg/L 3compartmentss NA 95% Human Human +DTXSID6021616 Css NA 0.8807 mg/L PBTK NA 50% Human Human +DTXSID6021616 Css NA 4.467 mg/L PBTK NA 95% Human Human +DTXSID6021616 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021616 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021616 Vd NA 1.085 L/kg 1compartment NA NA Rat Human +DTXSID6021616 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6021616 TK.Half.Life NA 3.499 hours 1compartment NA NA Rat Human +DTXSID6021616 Css NA 0.06039 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021616 Css NA 0.3897 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021616 Css NA 0.05273 mg/L PBTK NA 50% Rat Human +DTXSID6021616 Css NA 0.2441 mg/L PBTK NA 95% Rat Human +DTXSID6021618 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021618 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021618 Vd NA 0.3705 L/kg 1compartment NA NA Human Human +DTXSID6021618 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6021618 TK.Half.Life NA 0.7464 hours 1compartment NA NA Human Human +DTXSID6021618 Css NA 0.176 mg/L 3compartmentss NA 50% Human Human +DTXSID6021618 Css NA 1.453 mg/L 3compartmentss NA 95% Human Human +DTXSID6021618 Css NA 0.1146 mg/L PBTK NA 50% Human Human +DTXSID6021618 Css NA 0.9078 mg/L PBTK NA 95% Human Human +DTXSID6021618 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021618 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021618 Vd NA 0.365 L/kg 1compartment NA NA Rat Human DTXSID6021618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021618 TK.Half.Life NA 6.533 hours 1compartment NA NA Rat Human -DTXSID6021618 Css NA 2.714 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021618 Css NA 11.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021618 Css NA 1.594 mg/L PBTK NA 50% Rat Human -DTXSID6021618 Css NA 6.177 mg/L PBTK NA 95% Rat Human -DTXSID6021666 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021666 Fup NA 0.0169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021666 Vd NA 2.298 L/kg 1compartment NA NA Human Human -DTXSID6021666 Days.Css NA 435 Days PBTK NA NA Human Human -DTXSID6021666 TK.Half.Life NA 1650 hours 1compartment NA NA Human Human -DTXSID6021666 Css NA 100.9 mg/L 3compartmentss NA 50% Human Human -DTXSID6021666 Css NA 466 mg/L 3compartmentss NA 95% Human Human -DTXSID6021666 Css NA 68 mg/L PBTK NA 50% Human Human -DTXSID6021666 Css NA 283.5 mg/L PBTK NA 95% Human Human -DTXSID6021666 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021666 Fup NA 0.0169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021666 Vd NA 1.723 L/kg 1compartment NA NA Rat Human -DTXSID6021666 Days.Css NA 107 Days PBTK NA NA Rat Human -DTXSID6021666 TK.Half.Life NA 271.7 hours 1compartment NA NA Rat Human -DTXSID6021666 Css NA 27.96 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021666 Css NA 115.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021666 Css NA 17.8 mg/L PBTK NA 50% Rat Human -DTXSID6021666 Css NA 65.26 mg/L PBTK NA 95% Rat Human +DTXSID6021618 TK.Half.Life NA 0.4224 hours 1compartment NA NA Rat Human +DTXSID6021618 Css NA 0.02315 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021618 Css NA 0.1427 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021618 Css NA 0.01466 mg/L PBTK NA 50% Rat Human +DTXSID6021618 Css NA 0.08575 mg/L PBTK NA 95% Rat Human +DTXSID6021666 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021666 Fup 0.0273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021666 Vd NA 2.664 L/kg 1compartment NA NA Human Human +DTXSID6021666 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6021666 TK.Half.Life NA 24.03 hours 1compartment NA NA Human Human +DTXSID6021666 Css NA 1.177 mg/L 3compartmentss NA 50% Human Human +DTXSID6021666 Css NA 10.19 mg/L 3compartmentss NA 95% Human Human +DTXSID6021666 Css NA 0.8244 mg/L PBTK NA 50% Human Human +DTXSID6021666 Css NA 6.711 mg/L PBTK NA 95% Human Human +DTXSID6021666 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021666 Fup 0.0273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021666 Vd NA 2.008 L/kg 1compartment NA NA Rat Human +DTXSID6021666 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6021666 TK.Half.Life NA 7.001 hours 1compartment NA NA Rat Human +DTXSID6021666 Css NA 0.1534 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021666 Css NA 1.01 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021666 Css NA 0.1055 mg/L PBTK NA 50% Rat Human +DTXSID6021666 Css NA 0.6424 mg/L PBTK NA 95% Rat Human DTXSID6021668 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021668 Fup NA 0.4059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021668 Vd NA 1.041 L/kg 1compartment NA NA Human Human -DTXSID6021668 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6021668 TK.Half.Life NA 16.63 hours 1compartment NA NA Human Human -DTXSID6021668 Css NA 1.418 mg/L 3compartmentss NA 50% Human Human -DTXSID6021668 Css NA 6.931 mg/L 3compartmentss NA 95% Human Human -DTXSID6021668 Css NA 1.321 mg/L PBTK NA 50% Human Human -DTXSID6021668 Css NA 4.952 mg/L PBTK NA 95% Human Human +DTXSID6021668 Vd NA 0.9172 L/kg 1compartment NA NA Human Human +DTXSID6021668 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6021668 TK.Half.Life NA 14.64 hours 1compartment NA NA Human Human +DTXSID6021668 Css NA 1.26 mg/L 3compartmentss NA 50% Human Human +DTXSID6021668 Css NA 6.215 mg/L 3compartmentss NA 95% Human Human +DTXSID6021668 Css NA 1.115 mg/L PBTK NA 50% Human Human +DTXSID6021668 Css NA 4.291 mg/L PBTK NA 95% Human Human DTXSID6021668 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021668 Fup NA 0.4059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021668 Vd NA 1.04 L/kg 1compartment NA NA Rat Human +DTXSID6021668 Vd NA 0.9169 L/kg 1compartment NA NA Rat Human DTXSID6021668 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021668 TK.Half.Life NA 5.654 hours 1compartment NA NA Rat Human -DTXSID6021668 Css NA 0.3815 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021668 Css NA 1.654 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021668 Css NA 0.348 mg/L PBTK NA 50% Rat Human -DTXSID6021668 Css NA 1.09 mg/L PBTK NA 95% Rat Human -DTXSID6021741 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021741 Fup NA 0.8023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021741 Vd NA 1.633 L/kg 1compartment NA NA Human Human -DTXSID6021741 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6021741 TK.Half.Life NA 15.78 hours 1compartment NA NA Human Human -DTXSID6021741 Css NA 0.961 mg/L 3compartmentss NA 50% Human Human -DTXSID6021741 Css NA 5.788 mg/L 3compartmentss NA 95% Human Human -DTXSID6021741 Css NA 0.899 mg/L PBTK NA 50% Human Human -DTXSID6021741 Css NA 3.981 mg/L PBTK NA 95% Human Human -DTXSID6021741 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021741 Fup NA 0.8023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021741 Vd NA 1.431 L/kg 1compartment NA NA Rat Human +DTXSID6021668 TK.Half.Life NA 4.98 hours 1compartment NA NA Rat Human +DTXSID6021668 Css NA 0.0228 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021668 Css NA 0.1617 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021668 Css NA 0.01967 mg/L PBTK NA 50% Rat Human +DTXSID6021668 Css NA 0.1151 mg/L PBTK NA 95% Rat Human +DTXSID6021741 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021741 Fup 0.531 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021741 Vd NA 1.302 L/kg 1compartment NA NA Human Human +DTXSID6021741 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6021741 TK.Half.Life NA 1.247 hours 1compartment NA NA Human Human +DTXSID6021741 Css NA 0.0297 mg/L 3compartmentss NA 50% Human Human +DTXSID6021741 Css NA 0.3006 mg/L 3compartmentss NA 95% Human Human +DTXSID6021741 Css NA 0.02482 mg/L PBTK NA 50% Human Human +DTXSID6021741 Css NA 0.2152 mg/L PBTK NA 95% Human Human +DTXSID6021741 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021741 Fup 0.531 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021741 Vd NA 1.136 L/kg 1compartment NA NA Rat Human DTXSID6021741 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021741 TK.Half.Life NA 4.119 hours 1compartment NA NA Rat Human -DTXSID6021741 Css NA 0.2504 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021741 Css NA 1.483 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021741 Css NA 0.2276 mg/L PBTK NA 50% Rat Human -DTXSID6021741 Css NA 0.934 mg/L PBTK NA 95% Rat Human +DTXSID6021741 TK.Half.Life NA 0.532 hours 1compartment NA NA Rat Human +DTXSID6021741 Css NA 0.001067 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021741 Css NA 0.01268 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021741 Css NA 0.0008871 mg/L PBTK NA 50% Rat Human +DTXSID6021741 Css NA 0.008751 mg/L PBTK NA 95% Rat Human DTXSID6021793 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021793 Fup 0.0682 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021793 Vd NA 1.42 L/kg 1compartment NA NA Human Human DTXSID6021793 Days.Css NA 39 Days PBTK NA NA Human Human DTXSID6021793 TK.Half.Life NA 181.9 hours 1compartment NA NA Human Human -DTXSID6021793 Css NA 14.54 mg/L 3compartmentss NA 50% Human Human -DTXSID6021793 Css NA 54.6 mg/L 3compartmentss NA 95% Human Human -DTXSID6021793 Css NA 9.632 mg/L PBTK NA 50% Human Human -DTXSID6021793 Css NA 33.34 mg/L PBTK NA 95% Human Human +DTXSID6021793 Css NA 14.39 mg/L 3compartmentss NA 50% Human Human +DTXSID6021793 Css NA 52.7 mg/L 3compartmentss NA 95% Human Human +DTXSID6021793 Css NA 9.462 mg/L PBTK NA 50% Human Human +DTXSID6021793 Css NA 32.26 mg/L PBTK NA 95% Human Human DTXSID6021793 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021793 Fup 0.0682 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021793 Vd NA 1.077 L/kg 1compartment NA NA Rat Human DTXSID6021793 Days.Css NA 8 Days PBTK NA NA Rat Human DTXSID6021793 TK.Half.Life NA 37.71 hours 1compartment NA NA Rat Human -DTXSID6021793 Css NA 4.17 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021793 Css NA 12.76 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021793 Css NA 2.602 mg/L PBTK NA 50% Rat Human -DTXSID6021793 Css NA 7.278 mg/L PBTK NA 95% Rat Human -DTXSID6021795 Clint NA 5.433 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021795 Fup NA 0.0758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021795 Vd NA 2.255 L/kg 1compartment NA NA Human Human -DTXSID6021795 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6021795 TK.Half.Life NA 33.66 hours 1compartment NA NA Human Human -DTXSID6021795 Css NA 2.074 mg/L 3compartmentss NA 50% Human Human -DTXSID6021795 Css NA 11.85 mg/L 3compartmentss NA 95% Human Human -DTXSID6021795 Css NA 1.4 mg/L PBTK NA 50% Human Human -DTXSID6021795 Css NA 7.595 mg/L PBTK NA 95% Human Human -DTXSID6021795 Clint NA 5.433 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021795 Fup NA 0.0758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021795 Vd NA 1.697 L/kg 1compartment NA NA Rat Human -DTXSID6021795 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6021795 TK.Half.Life NA 9.306 hours 1compartment NA NA Rat Human -DTXSID6021795 Css NA 1.103 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021795 Css NA 4.554 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021795 Css NA 0.7034 mg/L PBTK NA 50% Rat Human -DTXSID6021795 Css NA 2.718 mg/L PBTK NA 95% Rat Human -DTXSID6021822 Clint NA 0.02204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021822 Fup NA 0.7096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021822 Vd NA 3.043 L/kg 1compartment NA NA Human Human +DTXSID6021793 Css NA 0.9395 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021793 Css NA 2.982 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021793 Css NA 0.608 mg/L PBTK NA 50% Rat Human +DTXSID6021793 Css NA 1.758 mg/L PBTK NA 95% Rat Human +DTXSID6021795 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021795 Fup 0.0287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021795 Vd NA 1.611 L/kg 1compartment NA NA Human Human +DTXSID6021795 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6021795 TK.Half.Life NA 11.64 hours 1compartment NA NA Human Human +DTXSID6021795 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human +DTXSID6021795 Css NA 9.06 mg/L 3compartmentss NA 95% Human Human +DTXSID6021795 Css NA 0.6764 mg/L PBTK NA 50% Human Human +DTXSID6021795 Css NA 5.45 mg/L PBTK NA 95% Human Human +DTXSID6021795 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021795 Fup 0.0287 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021795 Vd NA 1.2 L/kg 1compartment NA NA Rat Human +DTXSID6021795 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6021795 TK.Half.Life NA 4.338 hours 1compartment NA NA Rat Human +DTXSID6021795 Css NA 0.139 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021795 Css NA 0.953 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021795 Css NA 0.08583 mg/L PBTK NA 50% Rat Human +DTXSID6021795 Css NA 0.5614 mg/L PBTK NA 95% Rat Human +DTXSID6021822 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021822 Fup 0.665 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021822 Vd NA 2.791 L/kg 1compartment NA NA Human Human DTXSID6021822 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6021822 TK.Half.Life NA 26.74 hours 1compartment NA NA Human Human -DTXSID6021822 Css NA 0.6695 mg/L 3compartmentss NA 50% Human Human -DTXSID6021822 Css NA 5.477 mg/L 3compartmentss NA 95% Human Human -DTXSID6021822 Css NA 0.8336 mg/L PBTK NA 50% Human Human -DTXSID6021822 Css NA 4.061 mg/L PBTK NA 95% Human Human -DTXSID6021822 Clint NA 0.02204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021822 Fup NA 0.7096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021822 Vd NA 3.04 L/kg 1compartment NA NA Rat Human +DTXSID6021822 TK.Half.Life NA 27.16 hours 1compartment NA NA Human Human +DTXSID6021822 Css NA 0.6424 mg/L 3compartmentss NA 50% Human Human +DTXSID6021822 Css NA 5.572 mg/L 3compartmentss NA 95% Human Human +DTXSID6021822 Css NA 0.7711 mg/L PBTK NA 50% Human Human +DTXSID6021822 Css NA 4.092 mg/L PBTK NA 95% Human Human +DTXSID6021822 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021822 Fup 0.665 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021822 Vd NA 2.785 L/kg 1compartment NA NA Rat Human DTXSID6021822 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021822 TK.Half.Life NA 9.274 hours 1compartment NA NA Rat Human -DTXSID6021822 Css NA 0.1698 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021822 Css NA 1.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021822 Css NA 0.2136 mg/L PBTK NA 50% Rat Human -DTXSID6021822 Css NA 1.025 mg/L PBTK NA 95% Rat Human +DTXSID6021822 TK.Half.Life NA 9.237 hours 1compartment NA NA Rat Human +DTXSID6021822 Css NA 0.01202 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021822 Css NA 0.1294 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021822 Css NA 0.01419 mg/L PBTK NA 50% Rat Human +DTXSID6021822 Css NA 0.09793 mg/L PBTK NA 95% Rat Human DTXSID6021824 Clint 13.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021824 Fup 0.0045 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021824 Vd NA 1.656 L/kg 1compartment NA NA Human Human DTXSID6021824 Days.Css NA 10 Days PBTK NA NA Human Human DTXSID6021824 TK.Half.Life NA 64.9 hours 1compartment NA NA Human Human -DTXSID6021824 Css NA 4.575 mg/L 3compartmentss NA 50% Human Human -DTXSID6021824 Css NA 33.62 mg/L 3compartmentss NA 95% Human Human -DTXSID6021824 Css NA 2.9 mg/L PBTK NA 50% Human Human -DTXSID6021824 Css NA 21.12 mg/L PBTK NA 95% Human Human +DTXSID6021824 Css NA 4.456 mg/L 3compartmentss NA 50% Human Human +DTXSID6021824 Css NA 33.63 mg/L 3compartmentss NA 95% Human Human +DTXSID6021824 Css NA 2.842 mg/L PBTK NA 50% Human Human +DTXSID6021824 Css NA 21.06 mg/L PBTK NA 95% Human Human DTXSID6021824 Clint 13.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021824 Fup 0.0045 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021824 Vd NA 1.219 L/kg 1compartment NA NA Rat Human DTXSID6021824 Days.Css NA 5 Days PBTK NA NA Rat Human DTXSID6021824 TK.Half.Life NA 23.63 hours 1compartment NA NA Rat Human -DTXSID6021824 Css NA 2.603 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021824 Css NA 14.58 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021824 Css NA 1.562 mg/L PBTK NA 50% Rat Human -DTXSID6021824 Css NA 8.526 mg/L PBTK NA 95% Rat Human +DTXSID6021824 Css NA 0.5919 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021824 Css NA 3.242 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021824 Css NA 0.3675 mg/L PBTK NA 50% Rat Human +DTXSID6021824 Css NA 1.988 mg/L PBTK NA 95% Rat Human DTXSID6021828 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021828 Fup 0.326 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021828 Vd NA 1.027 L/kg 1compartment NA NA Human Human DTXSID6021828 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID6021828 TK.Half.Life NA 22.23 hours 1compartment NA NA Human Human -DTXSID6021828 Css NA 2.238 mg/L 3compartmentss NA 50% Human Human -DTXSID6021828 Css NA 7.091 mg/L 3compartmentss NA 95% Human Human -DTXSID6021828 Css NA 1.706 mg/L PBTK NA 50% Human Human -DTXSID6021828 Css NA 4.756 mg/L PBTK NA 95% Human Human +DTXSID6021828 Css NA 2.184 mg/L 3compartmentss NA 50% Human Human +DTXSID6021828 Css NA 6.896 mg/L 3compartmentss NA 95% Human Human +DTXSID6021828 Css NA 1.664 mg/L PBTK NA 50% Human Human +DTXSID6021828 Css NA 4.67 mg/L PBTK NA 95% Human Human DTXSID6021828 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021828 Fup 0.326 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021828 Vd NA 0.8857 L/kg 1compartment NA NA Rat Human DTXSID6021828 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021828 TK.Half.Life NA 6.123 hours 1compartment NA NA Rat Human -DTXSID6021828 Css NA 0.6112 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021828 Css NA 1.534 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021828 Css NA 0.4473 mg/L PBTK NA 50% Rat Human -DTXSID6021828 Css NA 0.9647 mg/L PBTK NA 95% Rat Human -DTXSID6021872 Clint NA 5.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6021828 Css NA 0.1382 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021828 Css NA 0.3492 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021828 Css NA 0.1047 mg/L PBTK NA 50% Rat Human +DTXSID6021828 Css NA 0.2273 mg/L PBTK NA 95% Rat Human +DTXSID6021872 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6021872 Fup 0.422 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6021872 Vd NA 1.047 L/kg 1compartment NA NA Human Human DTXSID6021872 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021872 TK.Half.Life NA 2.294 hours 1compartment NA NA Human Human -DTXSID6021872 Css NA 0.1718 mg/L 3compartmentss NA 50% Human Human -DTXSID6021872 Css NA 0.8976 mg/L 3compartmentss NA 95% Human Human -DTXSID6021872 Css NA 0.1355 mg/L PBTK NA 50% Human Human -DTXSID6021872 Css NA 0.6559 mg/L PBTK NA 95% Human Human -DTXSID6021872 Clint NA 5.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6021872 TK.Half.Life NA 1.129 hours 1compartment NA NA Human Human +DTXSID6021872 Css NA 0.04346 mg/L 3compartmentss NA 50% Human Human +DTXSID6021872 Css NA 0.2987 mg/L 3compartmentss NA 95% Human Human +DTXSID6021872 Css NA 0.03402 mg/L PBTK NA 50% Human Human +DTXSID6021872 Css NA 0.2189 mg/L PBTK NA 95% Human Human +DTXSID6021872 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6021872 Fup 0.422 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6021872 Vd NA 0.9291 L/kg 1compartment NA NA Rat Human DTXSID6021872 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021872 TK.Half.Life NA 1.098 hours 1compartment NA NA Rat Human -DTXSID6021872 Css NA 0.0852 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021872 Css NA 0.3223 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021872 Css NA 0.06562 mg/L PBTK NA 50% Rat Human -DTXSID6021872 Css NA 0.2203 mg/L PBTK NA 95% Rat Human +DTXSID6021872 TK.Half.Life NA 0.5059 hours 1compartment NA NA Rat Human +DTXSID6021872 Css NA 0.005408 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021872 Css NA 0.0272 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021872 Css NA 0.004304 mg/L PBTK NA 50% Rat Human +DTXSID6021872 Css NA 0.01997 mg/L PBTK NA 95% Rat Human +DTXSID60218962 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60218962 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60218962 Vd NA 0.3358 L/kg 1compartment NA NA Human Human +DTXSID60218962 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60218962 TK.Half.Life NA 1.689 hours 1compartment NA NA Human Human +DTXSID60218962 Css NA 0.2952 mg/L 3compartmentss NA 50% Human Human +DTXSID60218962 Css NA 1.686 mg/L 3compartmentss NA 95% Human Human +DTXSID60218962 Css NA 0.1956 mg/L PBTK NA 50% Human Human +DTXSID60218962 Css NA 1.052 mg/L PBTK NA 95% Human Human +DTXSID60218962 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60218962 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60218962 Vd NA 0.3361 L/kg 1compartment NA NA Rat Human +DTXSID60218962 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60218962 TK.Half.Life NA 0.9524 hours 1compartment NA NA Rat Human +DTXSID60218962 Css NA 0.002724 mg/L 3compartmentss NA 50% Rat Human +DTXSID60218962 Css NA 0.01369 mg/L 3compartmentss NA 95% Rat Human +DTXSID60218962 Css NA 0.001709 mg/L PBTK NA 50% Rat Human +DTXSID60218962 Css NA 0.008055 mg/L PBTK NA 95% Rat Human DTXSID6021907 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021907 Fup NA 0.7546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021907 Vd NA 0.7048 L/kg 1compartment NA NA Human Human DTXSID6021907 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6021907 TK.Half.Life NA 6.054 hours 1compartment NA NA Human Human -DTXSID6021907 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human -DTXSID6021907 Css NA 6.429 mg/L 3compartmentss NA 95% Human Human -DTXSID6021907 Css NA 0.8434 mg/L PBTK NA 50% Human Human -DTXSID6021907 Css NA 4.087 mg/L PBTK NA 95% Human Human +DTXSID6021907 Css NA 0.8856 mg/L 3compartmentss NA 50% Human Human +DTXSID6021907 Css NA 5.461 mg/L 3compartmentss NA 95% Human Human +DTXSID6021907 Css NA 0.7184 mg/L PBTK NA 50% Human Human +DTXSID6021907 Css NA 3.53 mg/L PBTK NA 95% Human Human DTXSID6021907 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021907 Fup NA 0.7546 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021907 Vd NA 0.7292 L/kg 1compartment NA NA Rat Human DTXSID6021907 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021907 TK.Half.Life NA 2.131 hours 1compartment NA NA Rat Human -DTXSID6021907 Css NA 0.2649 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021907 Css NA 1.622 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021907 Css NA 0.2089 mg/L PBTK NA 50% Rat Human -DTXSID6021907 Css NA 0.9632 mg/L PBTK NA 95% Rat Human +DTXSID6021907 Css NA 0.01641 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021907 Css NA 0.1312 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021907 Css NA 0.01292 mg/L PBTK NA 50% Rat Human +DTXSID6021907 Css NA 0.08338 mg/L PBTK NA 95% Rat Human DTXSID6021909 Clint NA 0.3685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021909 Fup NA 0.7435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021909 Vd NA 1.687 L/kg 1compartment NA NA Human Human DTXSID6021909 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6021909 TK.Half.Life NA 9.215 hours 1compartment NA NA Human Human -DTXSID6021909 Css NA 0.5289 mg/L 3compartmentss NA 50% Human Human -DTXSID6021909 Css NA 3.764 mg/L 3compartmentss NA 95% Human Human -DTXSID6021909 Css NA 0.5178 mg/L PBTK NA 50% Human Human -DTXSID6021909 Css NA 2.581 mg/L PBTK NA 95% Human Human +DTXSID6021909 Css NA 0.4472 mg/L 3compartmentss NA 50% Human Human +DTXSID6021909 Css NA 3.085 mg/L 3compartmentss NA 95% Human Human +DTXSID6021909 Css NA 0.4386 mg/L PBTK NA 50% Human Human +DTXSID6021909 Css NA 2.139 mg/L PBTK NA 95% Human Human DTXSID6021909 Clint NA 0.3685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021909 Fup NA 0.7435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6021909 Vd NA 1.671 L/kg 1compartment NA NA Rat Human DTXSID6021909 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6021909 TK.Half.Life NA 3.836 hours 1compartment NA NA Rat Human -DTXSID6021909 Css NA 0.1683 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021909 Css NA 1.268 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021909 Css NA 0.1631 mg/L PBTK NA 50% Rat Human -DTXSID6021909 Css NA 0.7956 mg/L PBTK NA 95% Rat Human -DTXSID6021953 Clint NA 173.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021953 Fup NA 0.0547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021953 Vd NA 0.6913 L/kg 1compartment NA NA Human Human +DTXSID6021909 Css NA 0.01069 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021909 Css NA 0.09094 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021909 Css NA 0.01018 mg/L PBTK NA 50% Rat Human +DTXSID6021909 Css NA 0.06479 mg/L PBTK NA 95% Rat Human +DTXSID6021953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021953 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021953 Vd NA 1.319 L/kg 1compartment NA NA Human Human DTXSID6021953 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021953 TK.Half.Life NA 0.9036 hours 1compartment NA NA Human Human -DTXSID6021953 Css NA 0.07349 mg/L 3compartmentss NA 50% Human Human -DTXSID6021953 Css NA 0.5927 mg/L 3compartmentss NA 95% Human Human -DTXSID6021953 Css NA 0.04516 mg/L PBTK NA 50% Human Human -DTXSID6021953 Css NA 0.354 mg/L PBTK NA 95% Human Human -DTXSID6021953 Clint NA 173.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021953 Fup NA 0.0547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021953 Vd NA 0.5465 L/kg 1compartment NA NA Rat Human +DTXSID6021953 TK.Half.Life NA 2.349 hours 1compartment NA NA Human Human +DTXSID6021953 Css NA 0.1214 mg/L 3compartmentss NA 50% Human Human +DTXSID6021953 Css NA 0.8761 mg/L 3compartmentss NA 95% Human Human +DTXSID6021953 Css NA 0.0857 mg/L PBTK NA 50% Human Human +DTXSID6021953 Css NA 0.5889 mg/L PBTK NA 95% Human Human +DTXSID6021953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021953 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021953 Vd NA 1.05 L/kg 1compartment NA NA Rat Human DTXSID6021953 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021953 TK.Half.Life NA 0.3612 hours 1compartment NA NA Rat Human -DTXSID6021953 Css NA 0.0409 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021953 Css NA 0.2937 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021953 Css NA 0.02359 mg/L PBTK NA 50% Rat Human -DTXSID6021953 Css NA 0.1649 mg/L PBTK NA 95% Rat Human -DTXSID6021957 Clint NA 53.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021957 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6021957 Vd NA 1.908 L/kg 1compartment NA NA Human Human -DTXSID6021957 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6021957 TK.Half.Life NA 7.031 hours 1compartment NA NA Human Human -DTXSID6021957 Css NA 0.4728 mg/L 3compartmentss NA 50% Human Human -DTXSID6021957 Css NA 3.923 mg/L 3compartmentss NA 95% Human Human -DTXSID6021957 Css NA 0.3052 mg/L PBTK NA 50% Human Human -DTXSID6021957 Css NA 2.409 mg/L PBTK NA 95% Human Human -DTXSID6021957 Clint NA 53.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021957 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6021957 Vd NA 1.421 L/kg 1compartment NA NA Rat Human +DTXSID6021953 TK.Half.Life NA 0.9582 hours 1compartment NA NA Rat Human +DTXSID6021953 Css NA 0.01562 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021953 Css NA 0.07941 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021953 Css NA 0.01094 mg/L PBTK NA 50% Rat Human +DTXSID6021953 Css NA 0.05292 mg/L PBTK NA 95% Rat Human +DTXSID6021957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021957 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6021957 Vd NA 1.721 L/kg 1compartment NA NA Human Human +DTXSID6021957 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6021957 TK.Half.Life NA 17.1 hours 1compartment NA NA Human Human +DTXSID6021957 Css NA 1.504 mg/L 3compartmentss NA 50% Human Human +DTXSID6021957 Css NA 13.33 mg/L 3compartmentss NA 95% Human Human +DTXSID6021957 Css NA 0.952 mg/L PBTK NA 50% Human Human +DTXSID6021957 Css NA 8.107 mg/L PBTK NA 95% Human Human +DTXSID6021957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021957 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6021957 Vd NA 1.276 L/kg 1compartment NA NA Rat Human DTXSID6021957 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6021957 TK.Half.Life NA 2.366 hours 1compartment NA NA Rat Human -DTXSID6021957 Css NA 0.2653 mg/L 3compartmentss NA 50% Rat Human -DTXSID6021957 Css NA 1.873 mg/L 3compartmentss NA 95% Rat Human -DTXSID6021957 Css NA 0.1612 mg/L PBTK NA 50% Rat Human -DTXSID6021957 Css NA 1.064 mg/L PBTK NA 95% Rat Human +DTXSID6021957 TK.Half.Life NA 6.123 hours 1compartment NA NA Rat Human +DTXSID6021957 Css NA 0.1949 mg/L 3compartmentss NA 50% Rat Human +DTXSID6021957 Css NA 1.402 mg/L 3compartmentss NA 95% Rat Human +DTXSID6021957 Css NA 0.1204 mg/L PBTK NA 50% Rat Human +DTXSID6021957 Css NA 0.8231 mg/L PBTK NA 95% Rat Human DTXSID6021959 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021959 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6021959 Vd NA 1.879 L/kg 1compartment NA NA Human Human -DTXSID6021959 Days.Css NA 412 Days PBTK NA NA Human Human +DTXSID6021959 Days.Css NA 415 Days PBTK NA NA Human Human DTXSID6021959 TK.Half.Life NA 1570 hours 1compartment NA NA Human Human -DTXSID6021959 Css NA 124.5 mg/L 3compartmentss NA 50% Human Human -DTXSID6021959 Css NA 590.6 mg/L 3compartmentss NA 95% Human Human -DTXSID6021959 Css NA 79.21 mg/L PBTK NA 50% Human Human -DTXSID6021959 Css NA 349 mg/L PBTK NA 95% Human Human +DTXSID6021959 Css NA 122.2 mg/L 3compartmentss NA 50% Human Human +DTXSID6021959 Css NA 565.9 mg/L 3compartmentss NA 95% Human Human +DTXSID6021959 Css NA 77.6 mg/L PBTK NA 50% Human Human +DTXSID6021959 Css NA 332.5 mg/L PBTK NA 95% Human Human DTXSID6021959 Clint 21.5 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID6021959 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID6021959 Css NA 2.226 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6021959 Css NA 16.41 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6021959 Css NA 0.5387 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6021959 Css NA 4.172 mg/L 3compartmentss NA 95% Rat Rat DTXSID6022000 Clint NA 0.09277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6022000 Fup NA 0.723 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6022000 Vd NA 1.369 L/kg 1compartment NA NA Human Human DTXSID6022000 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID6022000 TK.Half.Life NA 10.63 hours 1compartment NA NA Human Human -DTXSID6022000 Css NA 0.7904 mg/L 3compartmentss NA 50% Human Human -DTXSID6022000 Css NA 5.288 mg/L 3compartmentss NA 95% Human Human -DTXSID6022000 Css NA 0.7338 mg/L PBTK NA 50% Human Human -DTXSID6022000 Css NA 3.55 mg/L PBTK NA 95% Human Human +DTXSID6022000 Css NA 0.6759 mg/L 3compartmentss NA 50% Human Human +DTXSID6022000 Css NA 4.671 mg/L 3compartmentss NA 95% Human Human +DTXSID6022000 Css NA 0.629 mg/L PBTK NA 50% Human Human +DTXSID6022000 Css NA 3.112 mg/L PBTK NA 95% Human Human DTXSID6022000 Clint NA 0.09277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6022000 Fup NA 0.723 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6022000 Vd NA 1.395 L/kg 1compartment NA NA Rat Human DTXSID6022000 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6022000 TK.Half.Life NA 3.959 hours 1compartment NA NA Rat Human -DTXSID6022000 Css NA 0.22 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022000 Css NA 1.588 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022000 Css NA 0.1996 mg/L PBTK NA 50% Rat Human -DTXSID6022000 Css NA 0.9749 mg/L PBTK NA 95% Rat Human -DTXSID6022002 Clint NA 2.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022002 Fup NA 0.7792 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022002 Vd NA 3.246 L/kg 1compartment NA NA Human Human -DTXSID6022002 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022002 TK.Half.Life NA 6.938 hours 1compartment NA NA Human Human -DTXSID6022002 Css NA 0.1711 mg/L 3compartmentss NA 50% Human Human -DTXSID6022002 Css NA 1.35 mg/L 3compartmentss NA 95% Human Human -DTXSID6022002 Css NA 0.2012 mg/L PBTK NA 50% Human Human -DTXSID6022002 Css NA 1.041 mg/L PBTK NA 95% Human Human -DTXSID6022002 Clint NA 2.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022002 Fup NA 0.7792 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022002 Vd NA 3.308 L/kg 1compartment NA NA Rat Human +DTXSID6022000 Css NA 0.01392 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022000 Css NA 0.1232 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022000 Css NA 0.0126 mg/L PBTK NA 50% Rat Human +DTXSID6022000 Css NA 0.08381 mg/L PBTK NA 95% Rat Human +DTXSID6022002 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022002 Fup 0.715 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022002 Vd NA 1.991 L/kg 1compartment NA NA Human Human +DTXSID6022002 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6022002 TK.Half.Life NA 18.02 hours 1compartment NA NA Human Human +DTXSID6022002 Css NA 0.7273 mg/L 3compartmentss NA 50% Human Human +DTXSID6022002 Css NA 5.453 mg/L 3compartmentss NA 95% Human Human +DTXSID6022002 Css NA 0.7378 mg/L PBTK NA 50% Human Human +DTXSID6022002 Css NA 3.755 mg/L PBTK NA 95% Human Human +DTXSID6022002 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022002 Fup 0.715 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022002 Vd NA 2.02 L/kg 1compartment NA NA Rat Human DTXSID6022002 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022002 TK.Half.Life NA 3.759 hours 1compartment NA NA Rat Human -DTXSID6022002 Css NA 0.06807 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022002 Css NA 0.5776 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022002 Css NA 0.08236 mg/L PBTK NA 50% Rat Human -DTXSID6022002 Css NA 0.4054 mg/L PBTK NA 95% Rat Human -DTXSID6022008 Clint NA 9.632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022008 Fup NA 0.1933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022008 Vd NA 2.94 L/kg 1compartment NA NA Human Human -DTXSID6022008 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6022008 TK.Half.Life NA 30.89 hours 1compartment NA NA Human Human -DTXSID6022008 Css NA 1.181 mg/L 3compartmentss NA 50% Human Human -DTXSID6022008 Css NA 6.675 mg/L 3compartmentss NA 95% Human Human -DTXSID6022008 Css NA 0.8403 mg/L PBTK NA 50% Human Human -DTXSID6022008 Css NA 4.6 mg/L PBTK NA 95% Human Human -DTXSID6022008 Clint NA 9.632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022008 Fup NA 0.1933 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022008 Vd NA 2.218 L/kg 1compartment NA NA Rat Human -DTXSID6022008 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6022008 TK.Half.Life NA 5.492 hours 1compartment NA NA Rat Human -DTXSID6022008 Css NA 0.638 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022008 Css NA 2.779 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022008 Css NA 0.4362 mg/L PBTK NA 50% Rat Human -DTXSID6022008 Css NA 1.834 mg/L PBTK NA 95% Rat Human -DTXSID6022133 Clint NA 33.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022133 Fup NA 0.3493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022133 Vd NA 1.312 L/kg 1compartment NA NA Human Human +DTXSID6022002 TK.Half.Life NA 6.228 hours 1compartment NA NA Rat Human +DTXSID6022002 Css NA 0.01396 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022002 Css NA 0.1246 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022002 Css NA 0.01376 mg/L PBTK NA 50% Rat Human +DTXSID6022002 Css NA 0.08789 mg/L PBTK NA 95% Rat Human +DTXSID6022050 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022050 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022050 Vd NA 1.35 L/kg 1compartment NA NA Human Human +DTXSID6022050 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6022050 TK.Half.Life NA 2.294 hours 1compartment NA NA Human Human +DTXSID6022050 Css NA 0.1138 mg/L 3compartmentss NA 50% Human Human +DTXSID6022050 Css NA 0.786 mg/L 3compartmentss NA 95% Human Human +DTXSID6022050 Css NA 0.0812 mg/L PBTK NA 50% Human Human +DTXSID6022050 Css NA 0.5265 mg/L PBTK NA 95% Human Human +DTXSID6022050 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022050 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022050 Vd NA 1.077 L/kg 1compartment NA NA Rat Human +DTXSID6022050 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022050 TK.Half.Life NA 0.9303 hours 1compartment NA NA Rat Human +DTXSID6022050 Css NA 0.01443 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022050 Css NA 0.07421 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022050 Css NA 0.0103 mg/L PBTK NA 50% Rat Human +DTXSID6022050 Css NA 0.04942 mg/L PBTK NA 95% Rat Human +DTXSID6022133 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022133 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022133 Vd NA 0.4974 L/kg 1compartment NA NA Human Human DTXSID6022133 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022133 TK.Half.Life NA 1.372 hours 1compartment NA NA Human Human -DTXSID6022133 Css NA 0.04178 mg/L 3compartmentss NA 50% Human Human -DTXSID6022133 Css NA 0.3264 mg/L 3compartmentss NA 95% Human Human -DTXSID6022133 Css NA 0.03219 mg/L PBTK NA 50% Human Human -DTXSID6022133 Css NA 0.2248 mg/L PBTK NA 95% Human Human -DTXSID6022133 Clint NA 33.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022133 Fup NA 0.3493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022133 Vd NA 1.095 L/kg 1compartment NA NA Rat Human +DTXSID6022133 TK.Half.Life NA 0.5879 hours 1compartment NA NA Human Human +DTXSID6022133 Css NA 0.05333 mg/L 3compartmentss NA 50% Human Human +DTXSID6022133 Css NA 0.4205 mg/L 3compartmentss NA 95% Human Human +DTXSID6022133 Css NA 0.03824 mg/L PBTK NA 50% Human Human +DTXSID6022133 Css NA 0.2746 mg/L PBTK NA 95% Human Human +DTXSID6022133 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022133 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022133 Vd NA 0.5076 L/kg 1compartment NA NA Rat Human DTXSID6022133 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022133 TK.Half.Life NA 0.5559 hours 1compartment NA NA Rat Human -DTXSID6022133 Css NA 0.02304 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022133 Css NA 0.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022133 Css NA 0.01713 mg/L PBTK NA 50% Rat Human -DTXSID6022133 Css NA 0.08995 mg/L PBTK NA 95% Rat Human -DTXSID6022137 Clint NA 0.2877 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022137 Fup NA 0.7473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022137 Vd NA 1.286 L/kg 1compartment NA NA Human Human +DTXSID6022133 TK.Half.Life NA 0.3103 hours 1compartment NA NA Rat Human +DTXSID6022133 Css NA 0.006738 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022133 Css NA 0.04002 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022133 Css NA 0.0048 mg/L PBTK NA 50% Rat Human +DTXSID6022133 Css NA 0.02594 mg/L PBTK NA 95% Rat Human +DTXSID6022137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022137 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022137 Vd NA 1.121 L/kg 1compartment NA NA Human Human DTXSID6022137 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022137 TK.Half.Life NA 8.208 hours 1compartment NA NA Human Human -DTXSID6022137 Css NA 0.6479 mg/L 3compartmentss NA 50% Human Human -DTXSID6022137 Css NA 4.313 mg/L 3compartmentss NA 95% Human Human -DTXSID6022137 Css NA 0.5834 mg/L PBTK NA 50% Human Human -DTXSID6022137 Css NA 2.845 mg/L PBTK NA 95% Human Human -DTXSID6022137 Clint NA 0.2877 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022137 Fup NA 0.7473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022137 Vd NA 1.174 L/kg 1compartment NA NA Rat Human +DTXSID6022137 TK.Half.Life NA 1.083 hours 1compartment NA NA Human Human +DTXSID6022137 Css NA 0.03032 mg/L 3compartmentss NA 50% Human Human +DTXSID6022137 Css NA 0.3001 mg/L 3compartmentss NA 95% Human Human +DTXSID6022137 Css NA 0.02482 mg/L PBTK NA 50% Human Human +DTXSID6022137 Css NA 0.2106 mg/L PBTK NA 95% Human Human +DTXSID6022137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022137 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022137 Vd NA 1.003 L/kg 1compartment NA NA Rat Human DTXSID6022137 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022137 TK.Half.Life NA 2.869 hours 1compartment NA NA Rat Human -DTXSID6022137 Css NA 0.203 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022137 Css NA 1.347 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022137 Css NA 0.1785 mg/L PBTK NA 50% Rat Human -DTXSID6022137 Css NA 0.8271 mg/L PBTK NA 95% Rat Human +DTXSID6022137 TK.Half.Life NA 0.4807 hours 1compartment NA NA Rat Human +DTXSID6022137 Css NA 0.001053 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022137 Css NA 0.01258 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022137 Css NA 0.0008489 mg/L PBTK NA 50% Rat Human +DTXSID6022137 Css NA 0.008718 mg/L PBTK NA 95% Rat Human +DTXSID60221794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60221794 Fup 0.0273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60221794 Vd NA 2.871 L/kg 1compartment NA NA Human Human +DTXSID60221794 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID60221794 TK.Half.Life NA 41.86 hours 1compartment NA NA Human Human +DTXSID60221794 Css NA 1.828 mg/L 3compartmentss NA 50% Human Human +DTXSID60221794 Css NA 13.03 mg/L 3compartmentss NA 95% Human Human +DTXSID60221794 Css NA 1.244 mg/L PBTK NA 50% Human Human +DTXSID60221794 Css NA 8.628 mg/L PBTK NA 95% Human Human +DTXSID60221794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60221794 Fup 0.0273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60221794 Vd NA 2.149 L/kg 1compartment NA NA Rat Human +DTXSID60221794 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID60221794 TK.Half.Life NA 7.734 hours 1compartment NA NA Rat Human +DTXSID60221794 Css NA 0.2386 mg/L 3compartmentss NA 50% Rat Human +DTXSID60221794 Css NA 1.366 mg/L 3compartmentss NA 95% Rat Human +DTXSID60221794 Css NA 0.1597 mg/L PBTK NA 50% Rat Human +DTXSID60221794 Css NA 0.873 mg/L PBTK NA 95% Rat Human DTXSID6022187 Clint 106 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022187 Fup 0.0908 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022187 Vd NA 1.373 L/kg 1compartment NA NA Human Human DTXSID6022187 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6022187 TK.Half.Life NA 1.773 hours 1compartment NA NA Human Human -DTXSID6022187 Css NA 0.05914 mg/L 3compartmentss NA 50% Human Human -DTXSID6022187 Css NA 0.4057 mg/L 3compartmentss NA 95% Human Human -DTXSID6022187 Css NA 0.03903 mg/L PBTK NA 50% Human Human -DTXSID6022187 Css NA 0.2626 mg/L PBTK NA 95% Human Human +DTXSID6022187 Css NA 0.05444 mg/L 3compartmentss NA 50% Human Human +DTXSID6022187 Css NA 0.3952 mg/L 3compartmentss NA 95% Human Human +DTXSID6022187 Css NA 0.03634 mg/L PBTK NA 50% Human Human +DTXSID6022187 Css NA 0.2544 mg/L PBTK NA 95% Human Human DTXSID6022187 Clint 106 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022187 Fup 0.0908 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022187 Vd NA 1.052 L/kg 1compartment NA NA Rat Human DTXSID6022187 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6022187 TK.Half.Life NA 0.6533 hours 1compartment NA NA Rat Human -DTXSID6022187 Css NA 0.03314 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022187 Css NA 0.1858 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022187 Css NA 0.02093 mg/L PBTK NA 50% Rat Human -DTXSID6022187 Css NA 0.1119 mg/L PBTK NA 95% Rat Human +DTXSID6022187 Css NA 0.007284 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022187 Css NA 0.0421 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022187 Css NA 0.004769 mg/L PBTK NA 50% Rat Human +DTXSID6022187 Css NA 0.02696 mg/L PBTK NA 95% Rat Human DTXSID6022341 Clint 8.17 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022341 Fup 0.0289 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022341 Vd NA 1.088 L/kg 1compartment NA NA Human Human DTXSID6022341 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID6022341 TK.Half.Life NA 17.06 hours 1compartment NA NA Human Human -DTXSID6022341 Css NA 1.969 mg/L 3compartmentss NA 50% Human Human -DTXSID6022341 Css NA 13.22 mg/L 3compartmentss NA 95% Human Human -DTXSID6022341 Css NA 1.231 mg/L PBTK NA 50% Human Human -DTXSID6022341 Css NA 7.856 mg/L PBTK NA 95% Human Human +DTXSID6022341 Css NA 1.933 mg/L 3compartmentss NA 50% Human Human +DTXSID6022341 Css NA 12.7 mg/L 3compartmentss NA 95% Human Human +DTXSID6022341 Css NA 1.209 mg/L PBTK NA 50% Human Human +DTXSID6022341 Css NA 7.703 mg/L PBTK NA 95% Human Human DTXSID6022341 Clint 8.17 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022341 Fup 0.0289 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022341 Vd NA 0.8149 L/kg 1compartment NA NA Rat Human DTXSID6022341 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6022341 TK.Half.Life NA 7.252 hours 1compartment NA NA Rat Human -DTXSID6022341 Css NA 1.07 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022341 Css NA 5.397 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022341 Css NA 0.6291 mg/L PBTK NA 50% Rat Human -DTXSID6022341 Css NA 3.041 mg/L PBTK NA 95% Rat Human +DTXSID6022341 Css NA 0.2443 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022341 Css NA 1.215 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022341 Css NA 0.1482 mg/L PBTK NA 50% Rat Human +DTXSID6022341 Css NA 0.7158 mg/L PBTK NA 95% Rat Human DTXSID6022345 Clint 15.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022345 Fup 1.59e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6022345 Vd NA 11.03 L/kg 1compartment NA NA Human Human -DTXSID6022345 Days.Css NA 147 Days PBTK NA NA Human Human -DTXSID6022345 TK.Half.Life NA 629 hours 1compartment NA NA Human Human -DTXSID6022345 Css NA 3.311 mg/L 3compartmentss NA 50% Human Human -DTXSID6022345 Css NA 17.53 mg/L 3compartmentss NA 95% Human Human -DTXSID6022345 Css NA 4.395 mg/L PBTK NA 50% Human Human -DTXSID6022345 Css NA 23.1 mg/L PBTK NA 95% Human Human +DTXSID6022345 Vd NA 8.888 L/kg 1compartment NA NA Human Human +DTXSID6022345 Days.Css NA 115 Days PBTK NA NA Human Human +DTXSID6022345 TK.Half.Life NA 507.8 hours 1compartment NA NA Human Human +DTXSID6022345 Css NA 3.755 mg/L 3compartmentss NA 50% Human Human +DTXSID6022345 Css NA 21.67 mg/L 3compartmentss NA 95% Human Human +DTXSID6022345 Css NA 4.256 mg/L PBTK NA 50% Human Human +DTXSID6022345 Css NA 24.38 mg/L PBTK NA 95% Human Human DTXSID6022345 Clint 15.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022345 Fup 1.59e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6022345 Vd NA 8.728 L/kg 1compartment NA NA Rat Human -DTXSID6022345 Days.Css NA 86 Days PBTK NA NA Rat Human -DTXSID6022345 TK.Half.Life NA 348.3 hours 1compartment NA NA Rat Human -DTXSID6022345 Css NA 1.772 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022345 Css NA 7.681 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022345 Css NA 2.367 mg/L PBTK NA 50% Rat Human -DTXSID6022345 Css NA 11.28 mg/L PBTK NA 95% Rat Human +DTXSID6022345 Vd NA 6.957 L/kg 1compartment NA NA Rat Human +DTXSID6022345 Days.Css NA 68 Days PBTK NA NA Rat Human +DTXSID6022345 TK.Half.Life NA 277.9 hours 1compartment NA NA Rat Human +DTXSID6022345 Css NA 0.4698 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022345 Css NA 2.329 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022345 Css NA 0.5504 mg/L PBTK NA 50% Rat Human +DTXSID6022345 Css NA 2.842 mg/L PBTK NA 95% Rat Human DTXSID6022391 Clint 138 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022391 Fup 9.57e-05 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022391 Vd NA 0.1749 L/kg 1compartment NA NA Human Human DTXSID6022391 Days.Css NA 6 Days PBTK NA NA Human Human DTXSID6022391 TK.Half.Life NA 38.79 hours 1compartment NA NA Human Human -DTXSID6022391 Css NA 0.4545 mg/L 3compartmentss NA 50% Human Human -DTXSID6022391 Css NA 5.877 mg/L 3compartmentss NA 95% Human Human -DTXSID6022391 Css NA 0.269 mg/L PBTK NA 50% Human Human -DTXSID6022391 Css NA 3.363 mg/L PBTK NA 95% Human Human +DTXSID6022391 Css NA 0.4296 mg/L 3compartmentss NA 50% Human Human +DTXSID6022391 Css NA 5.649 mg/L 3compartmentss NA 95% Human Human +DTXSID6022391 Css NA 0.2558 mg/L PBTK NA 50% Human Human +DTXSID6022391 Css NA 3.284 mg/L PBTK NA 95% Human Human DTXSID6022391 Clint 85.7 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID6022391 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID6022391 Css NA 0.8121 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6022391 Css NA 6.918 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6022393 Clint NA 66.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022393 Fup NA 0.0278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022393 Vd NA 0.8864 L/kg 1compartment NA NA Human Human +DTXSID6022391 Css NA 0.1804 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6022391 Css NA 1.578 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6022393 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022393 Fup 0.0538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022393 Vd NA 1.102 L/kg 1compartment NA NA Human Human DTXSID6022393 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022393 TK.Half.Life NA 2.547 hours 1compartment NA NA Human Human -DTXSID6022393 Css NA 0.3617 mg/L 3compartmentss NA 50% Human Human -DTXSID6022393 Css NA 3.774 mg/L 3compartmentss NA 95% Human Human -DTXSID6022393 Css NA 0.2214 mg/L PBTK NA 50% Human Human -DTXSID6022393 Css NA 2.235 mg/L PBTK NA 95% Human Human -DTXSID6022393 Clint NA 66.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022393 Fup NA 0.0278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022393 Vd NA 0.6684 L/kg 1compartment NA NA Rat Human +DTXSID6022393 TK.Half.Life NA 4.587 hours 1compartment NA NA Human Human +DTXSID6022393 Css NA 0.5608 mg/L 3compartmentss NA 50% Human Human +DTXSID6022393 Css NA 4.358 mg/L 3compartmentss NA 95% Human Human +DTXSID6022393 Css NA 0.3501 mg/L PBTK NA 50% Human Human +DTXSID6022393 Css NA 2.612 mg/L PBTK NA 95% Human Human +DTXSID6022393 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022393 Fup 0.0538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022393 Vd NA 0.8381 L/kg 1compartment NA NA Rat Human DTXSID6022393 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022393 TK.Half.Life NA 1.094 hours 1compartment NA NA Rat Human -DTXSID6022393 Css NA 0.2066 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022393 Css NA 1.712 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022393 Css NA 0.1177 mg/L PBTK NA 50% Rat Human -DTXSID6022393 Css NA 0.951 mg/L PBTK NA 95% Rat Human -DTXSID6022399 Clint NA 1.945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022399 Fup NA 0.0369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022399 Vd NA 1.746 L/kg 1compartment NA NA Human Human -DTXSID6022399 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID6022399 TK.Half.Life NA 89.12 hours 1compartment NA NA Human Human -DTXSID6022399 Css NA 8.31 mg/L 3compartmentss NA 50% Human Human -DTXSID6022399 Css NA 46.43 mg/L 3compartmentss NA 95% Human Human -DTXSID6022399 Css NA 5.316 mg/L PBTK NA 50% Human Human -DTXSID6022399 Css NA 27.96 mg/L PBTK NA 95% Human Human -DTXSID6022399 Clint NA 1.945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022399 Fup NA 0.0369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022399 Vd NA 1.303 L/kg 1compartment NA NA Rat Human -DTXSID6022399 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID6022399 TK.Half.Life NA 27.65 hours 1compartment NA NA Rat Human -DTXSID6022399 Css NA 3.984 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022399 Css NA 17.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022399 Css NA 2.409 mg/L PBTK NA 50% Rat Human -DTXSID6022399 Css NA 9.589 mg/L PBTK NA 95% Rat Human -DTXSID6022420 Clint NA 2.576 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6022393 TK.Half.Life NA 1.959 hours 1compartment NA NA Rat Human +DTXSID6022393 Css NA 0.07282 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022393 Css NA 0.4398 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022393 Css NA 0.04462 mg/L PBTK NA 50% Rat Human +DTXSID6022393 Css NA 0.258 mg/L PBTK NA 95% Rat Human +DTXSID6022399 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022399 Fup 0.0368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022399 Vd NA 0.9292 L/kg 1compartment NA NA Human Human +DTXSID6022399 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6022399 TK.Half.Life NA 14.76 hours 1compartment NA NA Human Human +DTXSID6022399 Css NA 2.612 mg/L 3compartmentss NA 50% Human Human +DTXSID6022399 Css NA 18.6 mg/L 3compartmentss NA 95% Human Human +DTXSID6022399 Css NA 1.606 mg/L PBTK NA 50% Human Human +DTXSID6022399 Css NA 11.05 mg/L PBTK NA 95% Human Human +DTXSID6022399 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022399 Fup 0.0368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022399 Vd NA 0.7037 L/kg 1compartment NA NA Rat Human +DTXSID6022399 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022399 TK.Half.Life NA 6.454 hours 1compartment NA NA Rat Human +DTXSID6022399 Css NA 0.3252 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022399 Css NA 1.765 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022399 Css NA 0.1943 mg/L PBTK NA 50% Rat Human +DTXSID6022399 Css NA 1.018 mg/L PBTK NA 95% Rat Human +DTXSID6022420 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6022420 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6022420 Vd NA 1.809 L/kg 1compartment NA NA Human Human -DTXSID6022420 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022420 TK.Half.Life NA 3.125 hours 1compartment NA NA Human Human -DTXSID6022420 Css NA 0.158 mg/L 3compartmentss NA 50% Human Human -DTXSID6022420 Css NA 1.285 mg/L 3compartmentss NA 95% Human Human -DTXSID6022420 Css NA 0.1542 mg/L PBTK NA 50% Human Human -DTXSID6022420 Css NA 0.9203 mg/L PBTK NA 95% Human Human -DTXSID6022420 Clint NA 2.576 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6022420 Vd NA 1.81 L/kg 1compartment NA NA Human Human +DTXSID6022420 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6022420 TK.Half.Life NA 13.46 hours 1compartment NA NA Human Human +DTXSID6022420 Css NA 0.761 mg/L 3compartmentss NA 50% Human Human +DTXSID6022420 Css NA 4.98 mg/L 3compartmentss NA 95% Human Human +DTXSID6022420 Css NA 0.7564 mg/L PBTK NA 50% Human Human +DTXSID6022420 Css NA 3.496 mg/L PBTK NA 95% Human Human +DTXSID6022420 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6022420 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6022420 Vd NA 1.846 L/kg 1compartment NA NA Rat Human +DTXSID6022420 Vd NA 1.847 L/kg 1compartment NA NA Rat Human DTXSID6022420 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022420 TK.Half.Life NA 1.699 hours 1compartment NA NA Rat Human -DTXSID6022420 Css NA 0.06708 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022420 Css NA 0.4554 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022420 Css NA 0.06623 mg/L PBTK NA 50% Rat Human -DTXSID6022420 Css NA 0.3009 mg/L PBTK NA 95% Rat Human +DTXSID6022420 TK.Half.Life NA 4.68 hours 1compartment NA NA Rat Human +DTXSID6022420 Css NA 0.04422 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022420 Css NA 0.2784 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022420 Css NA 0.04505 mg/L PBTK NA 50% Rat Human +DTXSID6022420 Css NA 0.1868 mg/L PBTK NA 95% Rat Human DTXSID6022422 Clint 3.37 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022422 Fup 0.261 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022422 Vd NA 0.9199 L/kg 1compartment NA NA Human Human DTXSID6022422 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6022422 TK.Half.Life NA 4.104 hours 1compartment NA NA Human Human -DTXSID6022422 Css NA 0.4442 mg/L 3compartmentss NA 50% Human Human -DTXSID6022422 Css NA 2.042 mg/L 3compartmentss NA 95% Human Human -DTXSID6022422 Css NA 0.3225 mg/L PBTK NA 50% Human Human -DTXSID6022422 Css NA 1.399 mg/L PBTK NA 95% Human Human +DTXSID6022422 Css NA 0.4424 mg/L 3compartmentss NA 50% Human Human +DTXSID6022422 Css NA 1.981 mg/L 3compartmentss NA 95% Human Human +DTXSID6022422 Css NA 0.3199 mg/L PBTK NA 50% Human Human +DTXSID6022422 Css NA 1.351 mg/L PBTK NA 95% Human Human DTXSID6022422 Clint 3.37 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022422 Fup 0.261 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022422 Vd NA 0.792 L/kg 1compartment NA NA Rat Human DTXSID6022422 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6022422 TK.Half.Life NA 1.924 hours 1compartment NA NA Rat Human -DTXSID6022422 Css NA 0.2178 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022422 Css NA 0.6887 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022422 Css NA 0.1511 mg/L PBTK NA 50% Rat Human -DTXSID6022422 Css NA 0.4391 mg/L PBTK NA 95% Rat Human +DTXSID6022422 Css NA 0.04903 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022422 Css NA 0.153 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022422 Css NA 0.0352 mg/L PBTK NA 50% Rat Human +DTXSID6022422 Css NA 0.1014 mg/L PBTK NA 95% Rat Human DTXSID6022474 Clint 12.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022474 Fup 0.137 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022474 Vd NA 0.8527 L/kg 1compartment NA NA Human Human DTXSID6022474 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6022474 TK.Half.Life NA 2.607 hours 1compartment NA NA Human Human -DTXSID6022474 Css NA 0.2905 mg/L 3compartmentss NA 50% Human Human -DTXSID6022474 Css NA 1.675 mg/L 3compartmentss NA 95% Human Human -DTXSID6022474 Css NA 0.1944 mg/L PBTK NA 50% Human Human -DTXSID6022474 Css NA 1.087 mg/L PBTK NA 95% Human Human +DTXSID6022474 Css NA 0.2791 mg/L 3compartmentss NA 50% Human Human +DTXSID6022474 Css NA 1.632 mg/L 3compartmentss NA 95% Human Human +DTXSID6022474 Css NA 0.1874 mg/L PBTK NA 50% Human Human +DTXSID6022474 Css NA 1.055 mg/L PBTK NA 95% Human Human DTXSID6022474 Clint 12.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022474 Fup 0.137 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022474 Vd NA 0.698 L/kg 1compartment NA NA Rat Human DTXSID6022474 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6022474 TK.Half.Life NA 1.22 hours 1compartment NA NA Rat Human -DTXSID6022474 Css NA 0.1572 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022474 Css NA 0.6386 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022474 Css NA 0.09976 mg/L PBTK NA 50% Rat Human -DTXSID6022474 Css NA 0.3967 mg/L PBTK NA 95% Rat Human -DTXSID6022553 Clint NA 178.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022553 Fup NA 0.0057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022553 Vd NA 4.526 L/kg 1compartment NA NA Human Human -DTXSID6022553 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022553 TK.Half.Life NA 15.07 hours 1compartment NA NA Human Human -DTXSID6022553 Css NA 0.3499 mg/L 3compartmentss NA 50% Human Human -DTXSID6022553 Css NA 2.848 mg/L 3compartmentss NA 95% Human Human -DTXSID6022553 Css NA 0.2659 mg/L PBTK NA 50% Human Human -DTXSID6022553 Css NA 1.967 mg/L PBTK NA 95% Human Human -DTXSID6022553 Clint NA 178.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022553 Fup NA 0.0057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022553 Vd NA 3.444 L/kg 1compartment NA NA Rat Human -DTXSID6022553 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022553 TK.Half.Life NA 4.106 hours 1compartment NA NA Rat Human -DTXSID6022553 Css NA 0.1942 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022553 Css NA 1.303 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022553 Css NA 0.1429 mg/L PBTK NA 50% Rat Human -DTXSID6022553 Css NA 0.8695 mg/L PBTK NA 95% Rat Human -DTXSID6022555 Clint NA 21.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022555 Fup NA 0.0768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022555 Vd NA 2.625 L/kg 1compartment NA NA Human Human +DTXSID6022474 Css NA 0.03496 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022474 Css NA 0.1498 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022474 Css NA 0.02292 mg/L PBTK NA 50% Rat Human +DTXSID6022474 Css NA 0.09471 mg/L PBTK NA 95% Rat Human +DTXSID6022553 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022553 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022553 Vd NA 5.324 L/kg 1compartment NA NA Human Human +DTXSID6022553 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID6022553 TK.Half.Life NA 93.35 hours 1compartment NA NA Human Human +DTXSID6022553 Css NA 1.897 mg/L 3compartmentss NA 50% Human Human +DTXSID6022553 Css NA 14.02 mg/L 3compartmentss NA 95% Human Human +DTXSID6022553 Css NA 1.554 mg/L PBTK NA 50% Human Human +DTXSID6022553 Css NA 10.33 mg/L PBTK NA 95% Human Human +DTXSID6022553 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022553 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022553 Vd NA 4.08 L/kg 1compartment NA NA Rat Human +DTXSID6022553 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID6022553 TK.Half.Life NA 17.57 hours 1compartment NA NA Rat Human +DTXSID6022553 Css NA 0.2405 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022553 Css NA 1.485 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022553 Css NA 0.1985 mg/L PBTK NA 50% Rat Human +DTXSID6022553 Css NA 1.162 mg/L PBTK NA 95% Rat Human +DTXSID6022555 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022555 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022555 Vd NA 2.978 L/kg 1compartment NA NA Human Human DTXSID6022555 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6022555 TK.Half.Life NA 15.46 hours 1compartment NA NA Human Human -DTXSID6022555 Css NA 0.711 mg/L 3compartmentss NA 50% Human Human -DTXSID6022555 Css NA 4.654 mg/L 3compartmentss NA 95% Human Human -DTXSID6022555 Css NA 0.4857 mg/L PBTK NA 50% Human Human -DTXSID6022555 Css NA 3.023 mg/L PBTK NA 95% Human Human -DTXSID6022555 Clint NA 21.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022555 Fup NA 0.0768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022555 Vd NA 1.972 L/kg 1compartment NA NA Rat Human +DTXSID6022555 TK.Half.Life NA 16.28 hours 1compartment NA NA Human Human +DTXSID6022555 Css NA 0.5485 mg/L 3compartmentss NA 50% Human Human +DTXSID6022555 Css NA 3.521 mg/L 3compartmentss NA 95% Human Human +DTXSID6022555 Css NA 0.3919 mg/L PBTK NA 50% Human Human +DTXSID6022555 Css NA 2.407 mg/L PBTK NA 95% Human Human +DTXSID6022555 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022555 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022555 Vd NA 2.246 L/kg 1compartment NA NA Rat Human DTXSID6022555 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022555 TK.Half.Life NA 3.681 hours 1compartment NA NA Rat Human -DTXSID6022555 Css NA 0.3953 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022555 Css NA 2.043 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022555 Css NA 0.2581 mg/L PBTK NA 50% Rat Human -DTXSID6022555 Css NA 1.308 mg/L PBTK NA 95% Rat Human -DTXSID6022557 Clint NA 0.6853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022557 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022557 Vd NA 0.9254 L/kg 1compartment NA NA Human Human +DTXSID6022555 TK.Half.Life NA 3.018 hours 1compartment NA NA Rat Human +DTXSID6022555 Css NA 0.07036 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022555 Css NA 0.3646 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022555 Css NA 0.04992 mg/L PBTK NA 50% Rat Human +DTXSID6022555 Css NA 0.2524 mg/L PBTK NA 95% Rat Human +DTXSID6022557 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022557 Fup 0.64 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022557 Vd NA 0.7045 L/kg 1compartment NA NA Human Human DTXSID6022557 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022557 TK.Half.Life NA 2.966 hours 1compartment NA NA Human Human -DTXSID6022557 Css NA 0.3722 mg/L 3compartmentss NA 50% Human Human -DTXSID6022557 Css NA 2.573 mg/L 3compartmentss NA 95% Human Human -DTXSID6022557 Css NA 0.324 mg/L PBTK NA 50% Human Human -DTXSID6022557 Css NA 1.748 mg/L PBTK NA 95% Human Human -DTXSID6022557 Clint NA 0.6853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022557 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022557 Vd NA 0.9417 L/kg 1compartment NA NA Rat Human +DTXSID6022557 TK.Half.Life NA 7.149 hours 1compartment NA NA Human Human +DTXSID6022557 Css NA 1.116 mg/L 3compartmentss NA 50% Human Human +DTXSID6022557 Css NA 7.588 mg/L 3compartmentss NA 95% Human Human +DTXSID6022557 Css NA 0.897 mg/L PBTK NA 50% Human Human +DTXSID6022557 Css NA 4.74 mg/L PBTK NA 95% Human Human +DTXSID6022557 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022557 Fup 0.64 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022557 Vd NA 0.7156 L/kg 1compartment NA NA Rat Human DTXSID6022557 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022557 TK.Half.Life NA 1.37 hours 1compartment NA NA Rat Human -DTXSID6022557 Css NA 0.1301 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022557 Css NA 0.8684 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022557 Css NA 0.1123 mg/L PBTK NA 50% Rat Human -DTXSID6022557 Css NA 0.5318 mg/L PBTK NA 95% Rat Human +DTXSID6022557 TK.Half.Life NA 2.468 hours 1compartment NA NA Rat Human +DTXSID6022557 Css NA 0.0684 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022557 Css NA 0.4105 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022557 Css NA 0.05495 mg/L PBTK NA 50% Rat Human +DTXSID6022557 Css NA 0.2514 mg/L PBTK NA 95% Rat Human DTXSID6022559 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6022559 Fup NA 0.4693 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022559 Vd NA 0.3327 L/kg 1compartment NA NA Human Human +DTXSID6022559 Vd NA 0.338 L/kg 1compartment NA NA Human Human DTXSID6022559 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022559 TK.Half.Life NA 4.587 hours 1compartment NA NA Human Human -DTXSID6022559 Css NA 1.715 mg/L 3compartmentss NA 50% Human Human -DTXSID6022559 Css NA 7.679 mg/L 3compartmentss NA 95% Human Human -DTXSID6022559 Css NA 1.171 mg/L PBTK NA 50% Human Human -DTXSID6022559 Css NA 4.657 mg/L PBTK NA 95% Human Human +DTXSID6022559 TK.Half.Life NA 4.658 hours 1compartment NA NA Human Human +DTXSID6022559 Css NA 1.426 mg/L 3compartmentss NA 50% Human Human +DTXSID6022559 Css NA 6.71 mg/L 3compartmentss NA 95% Human Human +DTXSID6022559 Css NA 0.98 mg/L PBTK NA 50% Human Human +DTXSID6022559 Css NA 4.06 mg/L PBTK NA 95% Human Human DTXSID6022559 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6022559 Fup NA 0.4693 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022559 Vd NA 0.3484 L/kg 1compartment NA NA Rat Human +DTXSID6022559 Vd NA 0.3529 L/kg 1compartment NA NA Rat Human DTXSID6022559 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022559 TK.Half.Life NA 1.637 hours 1compartment NA NA Rat Human -DTXSID6022559 Css NA 0.4676 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022559 Css NA 1.814 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022559 Css NA 0.3014 mg/L PBTK NA 50% Rat Human -DTXSID6022559 Css NA 1.035 mg/L PBTK NA 95% Rat Human +DTXSID6022559 TK.Half.Life NA 1.658 hours 1compartment NA NA Rat Human +DTXSID6022559 Css NA 0.02709 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022559 Css NA 0.1792 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022559 Css NA 0.01772 mg/L PBTK NA 50% Rat Human +DTXSID6022559 Css NA 0.1072 mg/L PBTK NA 95% Rat Human DTXSID6022630 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6022630 Fup NA 0.5335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022630 Vd NA 2.685 L/kg 1compartment NA NA Human Human -DTXSID6022630 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID6022630 TK.Half.Life NA 115.8 hours 1compartment NA NA Human Human -DTXSID6022630 Css NA 4.591 mg/L 3compartmentss NA 50% Human Human -DTXSID6022630 Css NA 16 mg/L 3compartmentss NA 95% Human Human -DTXSID6022630 Css NA 3.645 mg/L PBTK NA 50% Human Human -DTXSID6022630 Css NA 11.11 mg/L PBTK NA 95% Human Human +DTXSID6022630 Vd NA 0.5308 L/kg 1compartment NA NA Human Human +DTXSID6022630 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6022630 TK.Half.Life NA 6.466 hours 1compartment NA NA Human Human +DTXSID6022630 Css NA 1.222 mg/L 3compartmentss NA 50% Human Human +DTXSID6022630 Css NA 7.279 mg/L 3compartmentss NA 95% Human Human +DTXSID6022630 Css NA 0.9102 mg/L PBTK NA 50% Human Human +DTXSID6022630 Css NA 4.547 mg/L PBTK NA 95% Human Human DTXSID6022630 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6022630 Fup NA 0.5335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022630 Vd NA 2.069 L/kg 1compartment NA NA Rat Human -DTXSID6022630 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID6022630 TK.Half.Life NA 13.76 hours 1compartment NA NA Rat Human -DTXSID6022630 Css NA 1.21 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022630 Css NA 3.614 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022630 Css NA 0.934 mg/L PBTK NA 50% Rat Human -DTXSID6022630 Css NA 2.293 mg/L PBTK NA 95% Rat Human -DTXSID6022632 Clint NA 10.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022632 Fup NA 0.4232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022632 Vd NA 2.465 L/kg 1compartment NA NA Human Human +DTXSID6022630 Vd NA 0.5248 L/kg 1compartment NA NA Rat Human +DTXSID6022630 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022630 TK.Half.Life NA 2.172 hours 1compartment NA NA Rat Human +DTXSID6022630 Css NA 0.03102 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022630 Css NA 0.2175 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022630 Css NA 0.02254 mg/L PBTK NA 50% Rat Human +DTXSID6022630 Css NA 0.1337 mg/L PBTK NA 95% Rat Human +DTXSID6022632 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022632 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022632 Vd NA 2.174 L/kg 1compartment NA NA Human Human DTXSID6022632 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022632 TK.Half.Life NA 3.705 hours 1compartment NA NA Human Human -DTXSID6022632 Css NA 0.09464 mg/L 3compartmentss NA 50% Human Human -DTXSID6022632 Css NA 0.7196 mg/L 3compartmentss NA 95% Human Human -DTXSID6022632 Css NA 0.08745 mg/L PBTK NA 50% Human Human -DTXSID6022632 Css NA 0.5594 mg/L PBTK NA 95% Human Human -DTXSID6022632 Clint NA 10.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022632 Fup NA 0.4232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022632 Vd NA 2.243 L/kg 1compartment NA NA Rat Human +DTXSID6022632 TK.Half.Life NA 4.229 hours 1compartment NA NA Human Human +DTXSID6022632 Css NA 0.1344 mg/L 3compartmentss NA 50% Human Human +DTXSID6022632 Css NA 0.9544 mg/L 3compartmentss NA 95% Human Human +DTXSID6022632 Css NA 0.1248 mg/L PBTK NA 50% Human Human +DTXSID6022632 Css NA 0.7318 mg/L PBTK NA 95% Human Human +DTXSID6022632 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022632 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022632 Vd NA 2.032 L/kg 1compartment NA NA Rat Human DTXSID6022632 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022632 TK.Half.Life NA 1.665 hours 1compartment NA NA Rat Human -DTXSID6022632 Css NA 0.0488 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022632 Css NA 0.2765 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022632 Css NA 0.04441 mg/L PBTK NA 50% Rat Human -DTXSID6022632 Css NA 0.2063 mg/L PBTK NA 95% Rat Human -DTXSID6022636 Clint NA 5.993 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022636 Fup NA 0.138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022636 Vd NA 3.077 L/kg 1compartment NA NA Human Human +DTXSID6022632 TK.Half.Life NA 2.069 hours 1compartment NA NA Rat Human +DTXSID6022632 Css NA 0.0156 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022632 Css NA 0.08836 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022632 Css NA 0.01456 mg/L PBTK NA 50% Rat Human +DTXSID6022632 Css NA 0.06473 mg/L PBTK NA 95% Rat Human +DTXSID6022636 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022636 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022636 Vd NA 4.174 L/kg 1compartment NA NA Human Human DTXSID6022636 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6022636 TK.Half.Life NA 18.55 hours 1compartment NA NA Human Human -DTXSID6022636 Css NA 0.6354 mg/L 3compartmentss NA 50% Human Human -DTXSID6022636 Css NA 4.273 mg/L 3compartmentss NA 95% Human Human -DTXSID6022636 Css NA 0.5265 mg/L PBTK NA 50% Human Human -DTXSID6022636 Css NA 3.126 mg/L PBTK NA 95% Human Human -DTXSID6022636 Clint NA 5.993 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022636 Fup NA 0.138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022636 Vd NA 2.668 L/kg 1compartment NA NA Rat Human -DTXSID6022636 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6022636 TK.Half.Life NA 6.589 hours 1compartment NA NA Rat Human -DTXSID6022636 Css NA 0.334 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022636 Css NA 1.59 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022636 Css NA 0.269 mg/L PBTK NA 50% Rat Human -DTXSID6022636 Css NA 1.114 mg/L PBTK NA 95% Rat Human +DTXSID6022636 TK.Half.Life NA 16.09 hours 1compartment NA NA Human Human +DTXSID6022636 Css NA 0.2943 mg/L 3compartmentss NA 50% Human Human +DTXSID6022636 Css NA 1.765 mg/L 3compartmentss NA 95% Human Human +DTXSID6022636 Css NA 0.2892 mg/L PBTK NA 50% Human Human +DTXSID6022636 Css NA 1.505 mg/L PBTK NA 95% Human Human +DTXSID6022636 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022636 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022636 Vd NA 3.658 L/kg 1compartment NA NA Rat Human +DTXSID6022636 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022636 TK.Half.Life NA 4.07 hours 1compartment NA NA Rat Human +DTXSID6022636 Css NA 0.03477 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022636 Css NA 0.1503 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022636 Css NA 0.03523 mg/L PBTK NA 50% Rat Human +DTXSID6022636 Css NA 0.1327 mg/L PBTK NA 95% Rat Human +DTXSID6022638 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID6022638 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6022638 Vd NA 5.013 L/kg 1compartment NA NA Human Human +DTXSID6022638 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6022638 TK.Half.Life NA 9.731 hours 1compartment NA NA Human Human +DTXSID6022638 Css NA 0.09468 mg/L 3compartmentss NA 50% Human Human +DTXSID6022638 Css NA 0.7462 mg/L 3compartmentss NA 95% Human Human +DTXSID6022638 Css NA 0.1396 mg/L PBTK NA 50% Human Human +DTXSID6022638 Css NA 0.8687 mg/L PBTK NA 95% Human Human +DTXSID6022638 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID6022638 Fup 0.17 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6022638 Vd NA 4.911 L/kg 1compartment NA NA Rat Human +DTXSID6022638 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022638 TK.Half.Life NA 5.056 hours 1compartment NA NA Rat Human +DTXSID6022638 Css NA 0.01123 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022638 Css NA 0.07041 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022638 Css NA 0.01756 mg/L PBTK NA 50% Rat Human +DTXSID6022638 Css NA 0.08185 mg/L PBTK NA 95% Rat Human +DTXSID6022680 Clint 7 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID6022680 Fup 0.097 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6022680 Vd NA 3.266 L/kg 1compartment NA NA Human Human +DTXSID6022680 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6022680 TK.Half.Life NA 9.584 hours 1compartment NA NA Human Human +DTXSID6022680 Css NA 0.2539 mg/L 3compartmentss NA 50% Human Human +DTXSID6022680 Css NA 2.34 mg/L 3compartmentss NA 95% Human Human +DTXSID6022680 Css NA 0.2476 mg/L PBTK NA 50% Human Human +DTXSID6022680 Css NA 1.819 mg/L PBTK NA 95% Human Human +DTXSID6022680 Clint 7 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID6022680 Fup 0.097 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6022680 Vd NA 4.465 L/kg 1compartment NA NA Rat Human +DTXSID6022680 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022680 TK.Half.Life NA 4.542 hours 1compartment NA NA Rat Human +DTXSID6022680 Css NA 0.01274 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022680 Css NA 0.07711 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022680 Css NA 0.01676 mg/L PBTK NA 50% Rat Human +DTXSID6022680 Css NA 0.07885 mg/L PBTK NA 95% Rat Human DTXSID6022682 Clint 1.6 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID6022682 Fup 0.66 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6022682 Vd NA 4.004 L/kg 1compartment NA NA Human Human DTXSID6022682 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6022682 TK.Half.Life NA 11.5 hours 1compartment NA NA Human Human -DTXSID6022682 Css NA 0.2592 mg/L 3compartmentss NA 50% Human Human -DTXSID6022682 Css NA 2.038 mg/L 3compartmentss NA 95% Human Human -DTXSID6022682 Css NA 0.2469 mg/L PBTK NA 50% Human Human +DTXSID6022682 Css NA 0.2431 mg/L 3compartmentss NA 50% Human Human +DTXSID6022682 Css NA 1.409 mg/L 3compartmentss NA 95% Human Human +DTXSID6022682 Css NA 0.242 mg/L PBTK NA 50% Human Human DTXSID6022682 Css NA 1.408 mg/L PBTK NA 95% Human Human DTXSID6022682 Clint 1.6 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID6022682 Fup 0.66 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6022682 Vd NA 4.917 L/kg 1compartment NA NA Rat Human DTXSID6022682 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6022682 TK.Half.Life NA 6.027 hours 1compartment NA NA Rat Human -DTXSID6022682 Css NA 0.09383 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022682 Css NA 0.6371 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022682 Css NA 0.08529 mg/L PBTK NA 50% Rat Human -DTXSID6022682 Css NA 0.4017 mg/L PBTK NA 95% Rat Human -DTXSID6022684 Clint NA 41.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022684 Fup NA 0.0413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022684 Vd NA 2.678 L/kg 1compartment NA NA Human Human -DTXSID6022684 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022684 TK.Half.Life NA 13.01 hours 1compartment NA NA Human Human -DTXSID6022684 Css NA 0.5937 mg/L 3compartmentss NA 50% Human Human -DTXSID6022684 Css NA 4.24 mg/L 3compartmentss NA 95% Human Human -DTXSID6022684 Css NA 0.405 mg/L PBTK NA 50% Human Human -DTXSID6022684 Css NA 2.758 mg/L PBTK NA 95% Human Human -DTXSID6022684 Clint NA 41.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022684 Fup NA 0.0413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022684 Vd NA 2.037 L/kg 1compartment NA NA Rat Human -DTXSID6022684 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022684 TK.Half.Life NA 3.256 hours 1compartment NA NA Rat Human -DTXSID6022684 Css NA 0.3313 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022684 Css NA 1.901 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022684 Css NA 0.2151 mg/L PBTK NA 50% Rat Human -DTXSID6022684 Css NA 1.197 mg/L PBTK NA 95% Rat Human -DTXSID6022688 Clint NA 10.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022688 Fup NA 0.0745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022688 Vd NA 2.427 L/kg 1compartment NA NA Human Human +DTXSID6022682 Css NA 0.01924 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022682 Css NA 0.08663 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022682 Css NA 0.01994 mg/L PBTK NA 50% Rat Human +DTXSID6022682 Css NA 0.08974 mg/L PBTK NA 95% Rat Human +DTXSID6022684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022684 Fup 0.0702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022684 Vd NA 2.942 L/kg 1compartment NA NA Human Human +DTXSID6022684 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6022684 TK.Half.Life NA 24.81 hours 1compartment NA NA Human Human +DTXSID6022684 Css NA 0.9682 mg/L 3compartmentss NA 50% Human Human +DTXSID6022684 Css NA 6.076 mg/L 3compartmentss NA 95% Human Human +DTXSID6022684 Css NA 0.6818 mg/L PBTK NA 50% Human Human +DTXSID6022684 Css NA 4.11 mg/L PBTK NA 95% Human Human +DTXSID6022684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022684 Fup 0.0702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022684 Vd NA 2.24 L/kg 1compartment NA NA Rat Human +DTXSID6022684 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6022684 TK.Half.Life NA 4.93 hours 1compartment NA NA Rat Human +DTXSID6022684 Css NA 0.1239 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022684 Css NA 0.671 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022684 Css NA 0.08568 mg/L PBTK NA 50% Rat Human +DTXSID6022684 Css NA 0.4532 mg/L PBTK NA 95% Rat Human +DTXSID6022688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022688 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022688 Vd NA 4.224 L/kg 1compartment NA NA Human Human DTXSID6022688 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022688 TK.Half.Life NA 9.064 hours 1compartment NA NA Human Human -DTXSID6022688 Css NA 0.4102 mg/L 3compartmentss NA 50% Human Human -DTXSID6022688 Css NA 3.415 mg/L 3compartmentss NA 95% Human Human -DTXSID6022688 Css NA 0.335 mg/L PBTK NA 50% Human Human -DTXSID6022688 Css NA 2.363 mg/L PBTK NA 95% Human Human -DTXSID6022688 Clint NA 10.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022688 Fup NA 0.0745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022688 Vd NA 2.312 L/kg 1compartment NA NA Rat Human +DTXSID6022688 TK.Half.Life NA 4.735 hours 1compartment NA NA Human Human +DTXSID6022688 Css NA 0.04882 mg/L 3compartmentss NA 50% Human Human +DTXSID6022688 Css NA 0.4011 mg/L 3compartmentss NA 95% Human Human +DTXSID6022688 Css NA 0.05716 mg/L PBTK NA 50% Human Human +DTXSID6022688 Css NA 0.375 mg/L PBTK NA 95% Human Human +DTXSID6022688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022688 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022688 Vd NA 4.101 L/kg 1compartment NA NA Rat Human DTXSID6022688 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022688 TK.Half.Life NA 4.997 hours 1compartment NA NA Rat Human -DTXSID6022688 Css NA 0.2251 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022688 Css NA 1.426 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022688 Css NA 0.176 mg/L PBTK NA 50% Rat Human -DTXSID6022688 Css NA 0.9606 mg/L PBTK NA 95% Rat Human -DTXSID6022715 Clint NA 9.053 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022715 Fup NA 0.052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022715 Vd NA 3.345 L/kg 1compartment NA NA Human Human +DTXSID6022688 TK.Half.Life NA 2.282 hours 1compartment NA NA Rat Human +DTXSID6022688 Css NA 0.005991 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022688 Css NA 0.03718 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022688 Css NA 0.007291 mg/L PBTK NA 50% Rat Human +DTXSID6022688 Css NA 0.03714 mg/L PBTK NA 95% Rat Human +DTXSID6022715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022715 Fup 0.0444 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022715 Vd NA 3.292 L/kg 1compartment NA NA Human Human DTXSID6022715 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022715 TK.Half.Life NA 13.24 hours 1compartment NA NA Human Human -DTXSID6022715 Css NA 0.3987 mg/L 3compartmentss NA 50% Human Human -DTXSID6022715 Css NA 2.627 mg/L 3compartmentss NA 95% Human Human -DTXSID6022715 Css NA 0.304 mg/L PBTK NA 50% Human Human -DTXSID6022715 Css NA 1.893 mg/L PBTK NA 95% Human Human -DTXSID6022715 Clint NA 9.053 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022715 Fup NA 0.052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022715 Vd NA 2.704 L/kg 1compartment NA NA Rat Human +DTXSID6022715 TK.Half.Life NA 7.064 hours 1compartment NA NA Human Human +DTXSID6022715 Css NA 0.1693 mg/L 3compartmentss NA 50% Human Human +DTXSID6022715 Css NA 1.175 mg/L 3compartmentss NA 95% Human Human +DTXSID6022715 Css NA 0.1269 mg/L PBTK NA 50% Human Human +DTXSID6022715 Css NA 0.836 mg/L PBTK NA 95% Human Human +DTXSID6022715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022715 Fup 0.0444 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022715 Vd NA 2.627 L/kg 1compartment NA NA Rat Human DTXSID6022715 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022715 TK.Half.Life NA 3.127 hours 1compartment NA NA Rat Human -DTXSID6022715 Css NA 0.2218 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022715 Css NA 1.216 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022715 Css NA 0.1644 mg/L PBTK NA 50% Rat Human -DTXSID6022715 Css NA 0.8697 mg/L PBTK NA 95% Rat Human -DTXSID6022719 Clint NA 31.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022719 Fup NA 0.238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022719 Vd NA 4.016 L/kg 1compartment NA NA Human Human +DTXSID6022715 TK.Half.Life NA 1.763 hours 1compartment NA NA Rat Human +DTXSID6022715 Css NA 0.02187 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022715 Css NA 0.1296 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022715 Css NA 0.01633 mg/L PBTK NA 50% Rat Human +DTXSID6022715 Css NA 0.09131 mg/L PBTK NA 95% Rat Human +DTXSID6022719 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022719 Fup 0.304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022719 Vd NA 2.1 L/kg 1compartment NA NA Human Human DTXSID6022719 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022719 TK.Half.Life NA 3.584 hours 1compartment NA NA Human Human -DTXSID6022719 Css NA 0.03395 mg/L 3compartmentss NA 50% Human Human -DTXSID6022719 Css NA 0.2899 mg/L 3compartmentss NA 95% Human Human -DTXSID6022719 Css NA 0.03908 mg/L PBTK NA 50% Human Human -DTXSID6022719 Css NA 0.2663 mg/L PBTK NA 95% Human Human -DTXSID6022719 Clint NA 31.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022719 Fup NA 0.238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022719 Vd NA 4.077 L/kg 1compartment NA NA Rat Human +DTXSID6022719 TK.Half.Life NA 3.375 hours 1compartment NA NA Human Human +DTXSID6022719 Css NA 0.0875 mg/L 3compartmentss NA 50% Human Human +DTXSID6022719 Css NA 0.6149 mg/L 3compartmentss NA 95% Human Human +DTXSID6022719 Css NA 0.06615 mg/L PBTK NA 50% Human Human +DTXSID6022719 Css NA 0.432 mg/L PBTK NA 95% Human Human +DTXSID6022719 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022719 Fup 0.304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022719 Vd NA 1.638 L/kg 1compartment NA NA Rat Human DTXSID6022719 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022719 TK.Half.Life NA 1.937 hours 1compartment NA NA Rat Human -DTXSID6022719 Css NA 0.01803 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022719 Css NA 0.1188 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022719 Css NA 0.02076 mg/L PBTK NA 50% Rat Human -DTXSID6022719 Css NA 0.1099 mg/L PBTK NA 95% Rat Human -DTXSID6022844 Clint NA 11.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6022719 TK.Half.Life NA 1.138 hours 1compartment NA NA Rat Human +DTXSID6022719 Css NA 0.004168 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022719 Css NA 0.03141 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022719 Css NA 0.003166 mg/L PBTK NA 50% Rat Human +DTXSID6022719 Css NA 0.02142 mg/L PBTK NA 95% Rat Human +DTXSID6022761 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022761 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6022761 Vd NA 0.4516 L/kg 1compartment NA NA Human Human +DTXSID6022761 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6022761 TK.Half.Life NA 4.871 hours 1compartment NA NA Human Human +DTXSID6022761 Css NA 0.7302 mg/L 3compartmentss NA 50% Human Human +DTXSID6022761 Css NA 4.905 mg/L 3compartmentss NA 95% Human Human +DTXSID6022761 Css NA 0.5334 mg/L PBTK NA 50% Human Human +DTXSID6022761 Css NA 3.016 mg/L PBTK NA 95% Human Human +DTXSID6022761 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022761 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6022761 Vd NA 0.4621 L/kg 1compartment NA NA Rat Human +DTXSID6022761 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022761 TK.Half.Life NA 1.698 hours 1compartment NA NA Rat Human +DTXSID6022761 Css NA 0.003855 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022761 Css NA 0.02736 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022761 Css NA 0.0027 mg/L PBTK NA 50% Rat Human +DTXSID6022761 Css NA 0.01588 mg/L PBTK NA 95% Rat Human +DTXSID6022763 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022763 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6022763 Vd NA 0.6208 L/kg 1compartment NA NA Human Human +DTXSID6022763 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6022763 TK.Half.Life NA 1.078 hours 1compartment NA NA Human Human +DTXSID6022763 Css NA 0.06722 mg/L 3compartmentss NA 50% Human Human +DTXSID6022763 Css NA 0.5752 mg/L 3compartmentss NA 95% Human Human +DTXSID6022763 Css NA 0.05009 mg/L PBTK NA 50% Human Human +DTXSID6022763 Css NA 0.3818 mg/L PBTK NA 95% Human Human +DTXSID6022763 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022763 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6022763 Vd NA 0.5926 L/kg 1compartment NA NA Rat Human +DTXSID6022763 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022763 TK.Half.Life NA 0.5594 hours 1compartment NA NA Rat Human +DTXSID6022763 Css NA 0.0006012 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022763 Css NA 0.004896 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022763 Css NA 0.0004368 mg/L PBTK NA 50% Rat Human +DTXSID6022763 Css NA 0.00303 mg/L PBTK NA 95% Rat Human +DTXSID6022767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022767 Fup 0.59 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6022767 Vd NA 1.451 L/kg 1compartment NA NA Human Human +DTXSID6022767 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6022767 TK.Half.Life NA 16.07 hours 1compartment NA NA Human Human +DTXSID6022767 Css NA 0.6015 mg/L 3compartmentss NA 50% Human Human +DTXSID6022767 Css NA 4.553 mg/L 3compartmentss NA 95% Human Human +DTXSID6022767 Css NA 0.544 mg/L PBTK NA 50% Human Human +DTXSID6022767 Css NA 3.01 mg/L PBTK NA 95% Human Human +DTXSID6022767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022767 Fup 0.59 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6022767 Vd NA 1.452 L/kg 1compartment NA NA Rat Human +DTXSID6022767 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022767 TK.Half.Life NA 5.441 hours 1compartment NA NA Rat Human +DTXSID6022767 Css NA 0.003139 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022767 Css NA 0.02469 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022767 Css NA 0.002749 mg/L PBTK NA 50% Rat Human +DTXSID6022767 Css NA 0.01556 mg/L PBTK NA 95% Rat Human +DTXSID6022844 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID6022844 Fup 0.029 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6022844 Vd NA 3.145 L/kg 1compartment NA NA Human Human -DTXSID6022844 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID6022844 TK.Half.Life NA 69.36 hours 1compartment NA NA Human Human -DTXSID6022844 Css NA 2.689 mg/L 3compartmentss NA 50% Human Human -DTXSID6022844 Css NA 17.24 mg/L 3compartmentss NA 95% Human Human -DTXSID6022844 Css NA 1.902 mg/L PBTK NA 50% Human Human -DTXSID6022844 Css NA 11.74 mg/L PBTK NA 95% Human Human -DTXSID6022844 Clint NA 11.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6022844 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID6022844 TK.Half.Life NA 85.26 hours 1compartment NA NA Human Human +DTXSID6022844 Css NA 3.252 mg/L 3compartmentss NA 50% Human Human +DTXSID6022844 Css NA 21.69 mg/L 3compartmentss NA 95% Human Human +DTXSID6022844 Css NA 2.314 mg/L PBTK NA 50% Human Human +DTXSID6022844 Css NA 14.85 mg/L PBTK NA 95% Human Human +DTXSID6022844 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID6022844 Fup 0.029 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6022844 Vd NA 2.399 L/kg 1compartment NA NA Rat Human -DTXSID6022844 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID6022844 TK.Half.Life NA 10.9 hours 1compartment NA NA Rat Human -DTXSID6022844 Css NA 1.51 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022844 Css NA 7.863 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022844 Css NA 1.021 mg/L PBTK NA 50% Rat Human -DTXSID6022844 Css NA 5.111 mg/L PBTK NA 95% Rat Human -DTXSID6022846 Clint NA 17.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6022844 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID6022844 TK.Half.Life NA 13.27 hours 1compartment NA NA Rat Human +DTXSID6022844 Css NA 0.4196 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022844 Css NA 2.295 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022844 Css NA 0.2948 mg/L PBTK NA 50% Rat Human +DTXSID6022844 Css NA 1.598 mg/L PBTK NA 95% Rat Human +DTXSID6022846 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6022846 Fup 0.56 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6022846 Vd NA 3.331 L/kg 1compartment NA NA Human Human -DTXSID6022846 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022846 TK.Half.Life NA 2.814 hours 1compartment NA NA Human Human -DTXSID6022846 Css NA 0.0283 mg/L 3compartmentss NA 50% Human Human -DTXSID6022846 Css NA 0.3114 mg/L 3compartmentss NA 95% Human Human -DTXSID6022846 Css NA 0.02808 mg/L PBTK NA 50% Human Human -DTXSID6022846 Css NA 0.2337 mg/L PBTK NA 95% Human Human -DTXSID6022846 Clint NA 17.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6022846 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID6022846 TK.Half.Life NA 38.68 hours 1compartment NA NA Human Human +DTXSID6022846 Css NA 0.9642 mg/L 3compartmentss NA 50% Human Human +DTXSID6022846 Css NA 5.38 mg/L 3compartmentss NA 95% Human Human +DTXSID6022846 Css NA 1.003 mg/L PBTK NA 50% Human Human +DTXSID6022846 Css NA 5.596 mg/L PBTK NA 95% Human Human +DTXSID6022846 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6022846 Fup 0.56 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6022846 Vd NA 3.388 L/kg 1compartment NA NA Rat Human -DTXSID6022846 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022846 TK.Half.Life NA 1.497 hours 1compartment NA NA Rat Human -DTXSID6022846 Css NA 0.01791 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022846 Css NA 0.181 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022846 Css NA 0.01774 mg/L PBTK NA 50% Rat Human -DTXSID6022846 Css NA 0.125 mg/L PBTK NA 95% Rat Human -DTXSID6022892 Clint NA 41.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022892 Fup NA 0.0582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022892 Vd NA 1.098 L/kg 1compartment NA NA Human Human +DTXSID6022846 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6022846 TK.Half.Life NA 13.36 hours 1compartment NA NA Rat Human +DTXSID6022846 Css NA 0.05742 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022846 Css NA 0.2783 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022846 Css NA 0.06185 mg/L PBTK NA 50% Rat Human +DTXSID6022846 Css NA 0.2995 mg/L PBTK NA 95% Rat Human +DTXSID6022848 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022848 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6022848 Vd NA 1.145 L/kg 1compartment NA NA Human Human +DTXSID6022848 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6022848 TK.Half.Life NA 10.19 hours 1compartment NA NA Human Human +DTXSID6022848 Css NA 1.418 mg/L 3compartmentss NA 50% Human Human +DTXSID6022848 Css NA 13.18 mg/L 3compartmentss NA 95% Human Human +DTXSID6022848 Css NA 0.8704 mg/L PBTK NA 50% Human Human +DTXSID6022848 Css NA 7.733 mg/L PBTK NA 95% Human Human +DTXSID6022848 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022848 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6022848 Vd NA 0.8514 L/kg 1compartment NA NA Rat Human +DTXSID6022848 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022848 TK.Half.Life NA 4.324 hours 1compartment NA NA Rat Human +DTXSID6022848 Css NA 0.1816 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022848 Css NA 1.413 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022848 Css NA 0.1087 mg/L PBTK NA 50% Rat Human +DTXSID6022848 Css NA 0.811 mg/L PBTK NA 95% Rat Human +DTXSID6022892 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022892 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022892 Vd NA 1.961 L/kg 1compartment NA NA Human Human DTXSID6022892 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022892 TK.Half.Life NA 2.655 hours 1compartment NA NA Human Human -DTXSID6022892 Css NA 0.2663 mg/L 3compartmentss NA 50% Human Human -DTXSID6022892 Css NA 2.17 mg/L 3compartmentss NA 95% Human Human -DTXSID6022892 Css NA 0.1704 mg/L PBTK NA 50% Human Human -DTXSID6022892 Css NA 1.333 mg/L PBTK NA 95% Human Human -DTXSID6022892 Clint NA 41.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022892 Fup NA 0.0582 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022892 Vd NA 0.9102 L/kg 1compartment NA NA Rat Human +DTXSID6022892 TK.Half.Life NA 11.6 hours 1compartment NA NA Human Human +DTXSID6022892 Css NA 0.6204 mg/L 3compartmentss NA 50% Human Human +DTXSID6022892 Css NA 4.121 mg/L 3compartmentss NA 95% Human Human +DTXSID6022892 Css NA 0.447 mg/L PBTK NA 50% Human Human +DTXSID6022892 Css NA 2.75 mg/L PBTK NA 95% Human Human +DTXSID6022892 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022892 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022892 Vd NA 1.618 L/kg 1compartment NA NA Rat Human DTXSID6022892 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022892 TK.Half.Life NA 1.237 hours 1compartment NA NA Rat Human -DTXSID6022892 Css NA 0.1533 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022892 Css NA 0.9489 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022892 Css NA 0.09299 mg/L PBTK NA 50% Rat Human -DTXSID6022892 Css NA 0.5572 mg/L PBTK NA 95% Rat Human -DTXSID6022894 Clint NA 40.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022894 Fup NA 0.0893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022894 Vd NA 1.934 L/kg 1compartment NA NA Human Human +DTXSID6022892 TK.Half.Life NA 4.633 hours 1compartment NA NA Rat Human +DTXSID6022892 Css NA 0.02796 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022892 Css NA 0.208 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022892 Css NA 0.01996 mg/L PBTK NA 50% Rat Human +DTXSID6022892 Css NA 0.1345 mg/L PBTK NA 95% Rat Human +DTXSID6022894 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022894 Fup 0.0506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022894 Vd NA 1.544 L/kg 1compartment NA NA Human Human DTXSID6022894 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022894 TK.Half.Life NA 4.381 hours 1compartment NA NA Human Human -DTXSID6022894 Css NA 0.2208 mg/L 3compartmentss NA 50% Human Human -DTXSID6022894 Css NA 1.644 mg/L 3compartmentss NA 95% Human Human -DTXSID6022894 Css NA 0.1479 mg/L PBTK NA 50% Human Human -DTXSID6022894 Css NA 1.06 mg/L PBTK NA 95% Human Human -DTXSID6022894 Clint NA 40.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022894 Fup NA 0.0893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022894 Vd NA 1.463 L/kg 1compartment NA NA Rat Human +DTXSID6022894 TK.Half.Life NA 7.256 hours 1compartment NA NA Human Human +DTXSID6022894 Css NA 0.6253 mg/L 3compartmentss NA 50% Human Human +DTXSID6022894 Css NA 4.881 mg/L 3compartmentss NA 95% Human Human +DTXSID6022894 Css NA 0.4018 mg/L PBTK NA 50% Human Human +DTXSID6022894 Css NA 2.957 mg/L PBTK NA 95% Human Human +DTXSID6022894 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022894 Fup 0.0506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022894 Vd NA 1.16 L/kg 1compartment NA NA Rat Human DTXSID6022894 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022894 TK.Half.Life NA 1.488 hours 1compartment NA NA Rat Human -DTXSID6022894 Css NA 0.1239 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022894 Css NA 0.7468 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022894 Css NA 0.07895 mg/L PBTK NA 50% Rat Human -DTXSID6022894 Css NA 0.4542 mg/L PBTK NA 95% Rat Human +DTXSID6022894 TK.Half.Life NA 2.763 hours 1compartment NA NA Rat Human +DTXSID6022894 Css NA 0.08152 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022894 Css NA 0.5046 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022894 Css NA 0.05103 mg/L PBTK NA 50% Rat Human +DTXSID6022894 Css NA 0.3015 mg/L PBTK NA 95% Rat Human DTXSID6022896 Clint 29.98 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6022896 Fup 0.18 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID6022896 Vd NA 3.155 L/kg 1compartment NA NA Human Human -DTXSID6022896 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6022896 TK.Half.Life NA 36.35 hours 1compartment NA NA Human Human -DTXSID6022896 Css NA 1.268 mg/L 3compartmentss NA 50% Human Human -DTXSID6022896 Css NA 7.836 mg/L 3compartmentss NA 95% Human Human -DTXSID6022896 Css NA 0.7441 mg/L PBTK NA 50% Human Human -DTXSID6022896 Css NA 4.515 mg/L PBTK NA 95% Human Human +DTXSID6022896 Vd NA 4.211 L/kg 1compartment NA NA Human Human +DTXSID6022896 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6022896 TK.Half.Life NA 4.273 hours 1compartment NA NA Human Human +DTXSID6022896 Css NA 0.0399 mg/L 3compartmentss NA 50% Human Human +DTXSID6022896 Css NA 0.2929 mg/L 3compartmentss NA 95% Human Human +DTXSID6022896 Css NA 0.03824 mg/L PBTK NA 50% Human Human +DTXSID6022896 Css NA 0.2808 mg/L PBTK NA 95% Human Human DTXSID6022896 Clint 29.98 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID6022896 Fup 0.18 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human -DTXSID6022896 Vd NA 2.379 L/kg 1compartment NA NA Rat Human -DTXSID6022896 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6022896 TK.Half.Life NA 5.127 hours 1compartment NA NA Rat Human -DTXSID6022896 Css NA 0.9183 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022896 Css NA 4.898 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022896 Css NA 0.5011 mg/L PBTK NA 50% Rat Human -DTXSID6022896 Css NA 2.664 mg/L PBTK NA 95% Rat Human -DTXSID6022898 Clint NA 23.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022898 Fup NA 0.0256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022898 Vd NA 3.041 L/kg 1compartment NA NA Human Human -DTXSID6022898 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID6022898 TK.Half.Life NA 57.71 hours 1compartment NA NA Human Human -DTXSID6022898 Css NA 2.35 mg/L 3compartmentss NA 50% Human Human -DTXSID6022898 Css NA 15.38 mg/L 3compartmentss NA 95% Human Human -DTXSID6022898 Css NA 1.628 mg/L PBTK NA 50% Human Human -DTXSID6022898 Css NA 10.42 mg/L PBTK NA 95% Human Human -DTXSID6022898 Clint NA 23.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022898 Fup NA 0.0256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022898 Vd NA 2.278 L/kg 1compartment NA NA Rat Human -DTXSID6022898 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID6022898 TK.Half.Life NA 8.782 hours 1compartment NA NA Rat Human -DTXSID6022898 Css NA 1.325 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022898 Css NA 6.882 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022898 Css NA 0.8722 mg/L PBTK NA 50% Rat Human -DTXSID6022898 Css NA 4.322 mg/L PBTK NA 95% Rat Human +DTXSID6022896 Vd NA 4.145 L/kg 1compartment NA NA Rat Human +DTXSID6022896 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6022896 TK.Half.Life NA 2.097 hours 1compartment NA NA Rat Human +DTXSID6022896 Css NA 0.004952 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022896 Css NA 0.02798 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022896 Css NA 0.004928 mg/L PBTK NA 50% Rat Human +DTXSID6022896 Css NA 0.02783 mg/L PBTK NA 95% Rat Human +DTXSID6022898 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022898 Fup 0.0163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022898 Vd NA 2.129 L/kg 1compartment NA NA Human Human +DTXSID6022898 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6022898 TK.Half.Life NA 25.65 hours 1compartment NA NA Human Human +DTXSID6022898 Css NA 1.768 mg/L 3compartmentss NA 50% Human Human +DTXSID6022898 Css NA 14.56 mg/L 3compartmentss NA 95% Human Human +DTXSID6022898 Css NA 1.144 mg/L PBTK NA 50% Human Human +DTXSID6022898 Css NA 9 mg/L PBTK NA 95% Human Human +DTXSID6022898 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022898 Fup 0.0163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022898 Vd NA 1.583 L/kg 1compartment NA NA Rat Human +DTXSID6022898 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6022898 TK.Half.Life NA 7.771 hours 1compartment NA NA Rat Human +DTXSID6022898 Css NA 0.2289 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022898 Css NA 1.478 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022898 Css NA 0.1447 mg/L PBTK NA 50% Rat Human +DTXSID6022898 Css NA 0.8994 mg/L PBTK NA 95% Rat Human DTXSID6022923 Clint 65.42 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6022923 Fup 0.005 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID6022923 Vd NA 1.224 L/kg 1compartment NA NA Human Human DTXSID6022923 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID6022923 TK.Half.Life NA 15.05 hours 1compartment NA NA Human Human -DTXSID6022923 Css NA 2.272 mg/L 3compartmentss NA 50% Human Human -DTXSID6022923 Css NA 23.17 mg/L 3compartmentss NA 95% Human Human -DTXSID6022923 Css NA 1.297 mg/L PBTK NA 50% Human Human -DTXSID6022923 Css NA 13.26 mg/L PBTK NA 95% Human Human +DTXSID6022923 Css NA 2.268 mg/L 3compartmentss NA 50% Human Human +DTXSID6022923 Css NA 24.24 mg/L 3compartmentss NA 95% Human Human +DTXSID6022923 Css NA 1.247 mg/L PBTK NA 50% Human Human +DTXSID6022923 Css NA 13.33 mg/L PBTK NA 95% Human Human DTXSID6022923 Clint 76.88 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID6022923 Fup 0.022 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID6022923 Vd NA 3.412 L/kg 1compartment NA NA Rat Rat +DTXSID6022923 Vd 0.87 3.412 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID6022923 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID6022923 TK.Half.Life NA 6.665 hours 1compartment NA NA Rat Rat -DTXSID6022923 Css NA 0.2532 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6022923 Css NA 2.109 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6022923 Css NA 0.135 mg/L PBTK NA 50% Rat Rat -DTXSID6022923 Css NA 1.129 mg/L PBTK NA 95% Rat Rat +DTXSID6022923 TK.Half.Life 0.2 6.665 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID6022923 Css 0.014 0.05546 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID6022923 Css 0.014 0.4646 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID6022923 Css 0.014 0.0316 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID6022923 Css 0.014 0.2646 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID6022927 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6022927 Fup 0.951 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6022927 Vd NA 1.804 L/kg 1compartment NA NA Human Human -DTXSID6022927 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6022927 TK.Half.Life NA 12.27 hours 1compartment NA NA Human Human -DTXSID6022927 Css NA 0.4936 mg/L 3compartmentss NA 50% Human Human -DTXSID6022927 Css NA 1.445 mg/L 3compartmentss NA 95% Human Human -DTXSID6022927 Css NA 0.4868 mg/L PBTK NA 50% Human Human -DTXSID6022927 Css NA 1.203 mg/L PBTK NA 95% Human Human +DTXSID6022927 Vd NA 0.7877 L/kg 1compartment NA NA Human Human +DTXSID6022927 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6022927 TK.Half.Life NA 5.365 hours 1compartment NA NA Human Human +DTXSID6022927 Css NA 0.5372 mg/L 3compartmentss NA 50% Human Human +DTXSID6022927 Css NA 1.382 mg/L 3compartmentss NA 95% Human Human +DTXSID6022927 Css NA 0.5802 mg/L PBTK NA 50% Human Human +DTXSID6022927 Css NA 1.493 mg/L PBTK NA 95% Human Human DTXSID6022927 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6022927 Fup 0.951 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6022927 Vd NA 1.871 L/kg 1compartment NA NA Rat Human +DTXSID6022927 Vd NA 0.8283 L/kg 1compartment NA NA Rat Human DTXSID6022927 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022927 TK.Half.Life NA 4.252 hours 1compartment NA NA Rat Human -DTXSID6022927 Css NA 0.1914 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022927 Css NA 1.132 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022927 Css NA 0.1816 mg/L PBTK NA 50% Rat Human -DTXSID6022927 Css NA 0.727 mg/L PBTK NA 95% Rat Human -DTXSID6022973 Clint NA 38.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022973 Fup NA 0.0767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022973 Vd NA 2.246 L/kg 1compartment NA NA Human Human -DTXSID6022973 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022973 TK.Half.Life NA 5.874 hours 1compartment NA NA Human Human -DTXSID6022973 Css NA 0.2695 mg/L 3compartmentss NA 50% Human Human -DTXSID6022973 Css NA 1.987 mg/L 3compartmentss NA 95% Human Human -DTXSID6022973 Css NA 0.1872 mg/L PBTK NA 50% Human Human -DTXSID6022973 Css NA 1.302 mg/L PBTK NA 95% Human Human -DTXSID6022973 Clint NA 38.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022973 Fup NA 0.0767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022973 Vd NA 1.776 L/kg 1compartment NA NA Rat Human +DTXSID6022927 TK.Half.Life NA 1.883 hours 1compartment NA NA Rat Human +DTXSID6022927 Css NA 0.01462 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022927 Css NA 0.07397 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022927 Css NA 0.016 mg/L PBTK NA 50% Rat Human +DTXSID6022927 Css NA 0.08114 mg/L PBTK NA 95% Rat Human +DTXSID60229659 Clint 6.46 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60229659 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60229659 Vd NA 2.997 L/kg 1compartment NA NA Human Human +DTXSID60229659 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID60229659 TK.Half.Life NA 40.11 hours 1compartment NA NA Human Human +DTXSID60229659 Css NA 1.475 mg/L 3compartmentss NA 50% Human Human +DTXSID60229659 Css NA 7.986 mg/L 3compartmentss NA 95% Human Human +DTXSID60229659 Css NA 1.062 mg/L PBTK NA 50% Human Human +DTXSID60229659 Css NA 5.52 mg/L PBTK NA 95% Human Human +DTXSID60229659 Clint 6.46 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60229659 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60229659 Vd NA 2.269 L/kg 1compartment NA NA Rat Human +DTXSID60229659 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID60229659 TK.Half.Life NA 6.627 hours 1compartment NA NA Rat Human +DTXSID60229659 Css NA 0.1801 mg/L 3compartmentss NA 50% Rat Human +DTXSID60229659 Css NA 0.7189 mg/L 3compartmentss NA 95% Rat Human +DTXSID60229659 Css NA 0.129 mg/L PBTK NA 50% Rat Human +DTXSID60229659 Css NA 0.4964 mg/L PBTK NA 95% Rat Human +DTXSID6022973 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022973 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022973 Vd NA 2.095 L/kg 1compartment NA NA Human Human +DTXSID6022973 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6022973 TK.Half.Life NA 17.44 hours 1compartment NA NA Human Human +DTXSID6022973 Css NA 1.056 mg/L 3compartmentss NA 50% Human Human +DTXSID6022973 Css NA 6.477 mg/L 3compartmentss NA 95% Human Human +DTXSID6022973 Css NA 0.7242 mg/L PBTK NA 50% Human Human +DTXSID6022973 Css NA 4.118 mg/L PBTK NA 95% Human Human +DTXSID6022973 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022973 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022973 Vd NA 1.583 L/kg 1compartment NA NA Rat Human DTXSID6022973 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022973 TK.Half.Life NA 2.043 hours 1compartment NA NA Rat Human -DTXSID6022973 Css NA 0.1501 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022973 Css NA 0.8721 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022973 Css NA 0.09989 mg/L PBTK NA 50% Rat Human -DTXSID6022973 Css NA 0.5507 mg/L PBTK NA 95% Rat Human -DTXSID6022975 Clint NA 6.562 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022975 Fup NA 0.7617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022975 Vd NA 0.6618 L/kg 1compartment NA NA Human Human +DTXSID6022973 TK.Half.Life NA 5.271 hours 1compartment NA NA Rat Human +DTXSID6022973 Css NA 0.1296 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022973 Css NA 0.5563 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022973 Css NA 0.0872 mg/L PBTK NA 50% Rat Human +DTXSID6022973 Css NA 0.3476 mg/L PBTK NA 95% Rat Human +DTXSID6022975 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022975 Fup 0.819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6022975 Vd NA 0.6423 L/kg 1compartment NA NA Human Human DTXSID6022975 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022975 TK.Half.Life NA 0.8199 hours 1compartment NA NA Human Human -DTXSID6022975 Css NA 0.0944 mg/L 3compartmentss NA 50% Human Human -DTXSID6022975 Css NA 0.7901 mg/L 3compartmentss NA 95% Human Human -DTXSID6022975 Css NA 0.0749 mg/L PBTK NA 50% Human Human -DTXSID6022975 Css NA 0.5351 mg/L PBTK NA 95% Human Human -DTXSID6022975 Clint NA 6.562 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022975 Fup NA 0.7617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022975 Vd NA 0.6934 L/kg 1compartment NA NA Rat Human +DTXSID6022975 TK.Half.Life NA 5.074 hours 1compartment NA NA Human Human +DTXSID6022975 Css NA 0.8665 mg/L 3compartmentss NA 50% Human Human +DTXSID6022975 Css NA 5.183 mg/L 3compartmentss NA 95% Human Human +DTXSID6022975 Css NA 0.6974 mg/L PBTK NA 50% Human Human +DTXSID6022975 Css NA 3.373 mg/L PBTK NA 95% Human Human +DTXSID6022975 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022975 Fup 0.819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6022975 Vd NA 0.6827 L/kg 1compartment NA NA Rat Human DTXSID6022975 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022975 TK.Half.Life NA 0.4522 hours 1compartment NA NA Rat Human -DTXSID6022975 Css NA 0.04503 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022975 Css NA 0.3437 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022975 Css NA 0.03518 mg/L PBTK NA 50% Rat Human -DTXSID6022975 Css NA 0.2118 mg/L PBTK NA 95% Rat Human +DTXSID6022975 TK.Half.Life NA 1.838 hours 1compartment NA NA Rat Human +DTXSID6022975 Css NA 0.02238 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022975 Css NA 0.1547 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022975 Css NA 0.01743 mg/L PBTK NA 50% Rat Human +DTXSID6022975 Css NA 0.09869 mg/L PBTK NA 95% Rat Human DTXSID6022977 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6022977 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6022977 Vd NA 0.9122 L/kg 1compartment NA NA Human Human +DTXSID6022977 Vd NA 0.8883 L/kg 1compartment NA NA Human Human DTXSID6022977 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6022977 TK.Half.Life NA 5.904 hours 1compartment NA NA Human Human -DTXSID6022977 Css NA 0.8136 mg/L 3compartmentss NA 50% Human Human -DTXSID6022977 Css NA 5.506 mg/L 3compartmentss NA 95% Human Human -DTXSID6022977 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID6022977 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID6022977 TK.Half.Life NA 5.747 hours 1compartment NA NA Human Human +DTXSID6022977 Css NA 0.6675 mg/L 3compartmentss NA 50% Human Human +DTXSID6022977 Css NA 4.898 mg/L 3compartmentss NA 95% Human Human +DTXSID6022977 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID6022977 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID6022977 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6022977 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6022977 Vd NA 0.9526 L/kg 1compartment NA NA Rat Human +DTXSID6022977 Vd NA 0.9187 L/kg 1compartment NA NA Rat Human DTXSID6022977 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6022977 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human -DTXSID6022977 Css NA 0.2038 mg/L 3compartmentss NA 50% Rat Human -DTXSID6022977 Css NA 1.321 mg/L 3compartmentss NA 95% Rat Human -DTXSID6022977 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID6022977 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID6023020 Clint NA 6.425 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023020 Fup NA 0.4646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023020 Vd NA 0.7619 L/kg 1compartment NA NA Human Human +DTXSID6022977 TK.Half.Life NA 2.026 hours 1compartment NA NA Rat Human +DTXSID6022977 Css NA 0.01216 mg/L 3compartmentss NA 50% Rat Human +DTXSID6022977 Css NA 0.09681 mg/L 3compartmentss NA 95% Rat Human +DTXSID6022977 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID6022977 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID6023020 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023020 Fup 0.415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023020 Vd NA 0.7144 L/kg 1compartment NA NA Human Human DTXSID6023020 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023020 TK.Half.Life NA 1.369 hours 1compartment NA NA Human Human -DTXSID6023020 Css NA 0.1431 mg/L 3compartmentss NA 50% Human Human -DTXSID6023020 Css NA 0.9838 mg/L 3compartmentss NA 95% Human Human -DTXSID6023020 Css NA 0.1092 mg/L PBTK NA 50% Human Human -DTXSID6023020 Css NA 0.6582 mg/L PBTK NA 95% Human Human -DTXSID6023020 Clint NA 6.425 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023020 Fup NA 0.4646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023020 Vd NA 0.7134 L/kg 1compartment NA NA Rat Human +DTXSID6023020 TK.Half.Life NA 1.42 hours 1compartment NA NA Human Human +DTXSID6023020 Css NA 0.1554 mg/L 3compartmentss NA 50% Human Human +DTXSID6023020 Css NA 1.081 mg/L 3compartmentss NA 95% Human Human +DTXSID6023020 Css NA 0.1168 mg/L PBTK NA 50% Human Human +DTXSID6023020 Css NA 0.7262 mg/L PBTK NA 95% Human Human +DTXSID6023020 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023020 Fup 0.415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023020 Vd NA 0.6682 L/kg 1compartment NA NA Rat Human DTXSID6023020 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023020 TK.Half.Life NA 0.6989 hours 1compartment NA NA Rat Human -DTXSID6023020 Css NA 0.07001 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023020 Css NA 0.3771 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023020 Css NA 0.05192 mg/L PBTK NA 50% Rat Human -DTXSID6023020 Css NA 0.2356 mg/L PBTK NA 95% Rat Human -DTXSID6023024 Clint NA 11.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023024 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023024 Vd NA 2.971 L/kg 1compartment NA NA Human Human -DTXSID6023024 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID6023024 TK.Half.Life NA 106.4 hours 1compartment NA NA Human Human -DTXSID6023024 Css NA 4.71 mg/L 3compartmentss NA 50% Human Human -DTXSID6023024 Css NA 28.96 mg/L 3compartmentss NA 95% Human Human -DTXSID6023024 Css NA 3.24 mg/L PBTK NA 50% Human Human -DTXSID6023024 Css NA 19.2 mg/L PBTK NA 95% Human Human -DTXSID6023024 Clint NA 11.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023024 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023024 Vd NA 2.224 L/kg 1compartment NA NA Rat Human -DTXSID6023024 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID6023024 TK.Half.Life NA 17.08 hours 1compartment NA NA Rat Human -DTXSID6023024 Css NA 2.598 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023024 Css NA 13.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023024 Css NA 1.699 mg/L PBTK NA 50% Rat Human -DTXSID6023024 Css NA 8.311 mg/L PBTK NA 95% Rat Human +DTXSID6023020 TK.Half.Life NA 0.7322 hours 1compartment NA NA Rat Human +DTXSID6023020 Css NA 0.018 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023020 Css NA 0.09094 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023020 Css NA 0.01346 mg/L PBTK NA 50% Rat Human +DTXSID6023020 Css NA 0.05938 mg/L PBTK NA 95% Rat Human +DTXSID6023024 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023024 Fup 0.0299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023024 Vd NA 3.006 L/kg 1compartment NA NA Human Human +DTXSID6023024 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID6023024 TK.Half.Life NA 53.61 hours 1compartment NA NA Human Human +DTXSID6023024 Css NA 2.186 mg/L 3compartmentss NA 50% Human Human +DTXSID6023024 Css NA 15.07 mg/L 3compartmentss NA 95% Human Human +DTXSID6023024 Css NA 1.494 mg/L PBTK NA 50% Human Human +DTXSID6023024 Css NA 9.874 mg/L PBTK NA 95% Human Human +DTXSID6023024 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023024 Fup 0.0299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023024 Vd NA 2.252 L/kg 1compartment NA NA Rat Human +DTXSID6023024 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID6023024 TK.Half.Life NA 8.525 hours 1compartment NA NA Rat Human +DTXSID6023024 Css NA 0.2838 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023024 Css NA 1.536 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023024 Css NA 0.1933 mg/L PBTK NA 50% Rat Human +DTXSID6023024 Css NA 1.021 mg/L PBTK NA 95% Rat Human DTXSID6023028 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023028 Fup NA 0.6977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023028 Vd NA 0.4444 L/kg 1compartment NA NA Human Human +DTXSID6023028 Vd NA 0.376 L/kg 1compartment NA NA Human Human DTXSID6023028 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023028 TK.Half.Life NA 4.121 hours 1compartment NA NA Human Human -DTXSID6023028 Css NA 1.208 mg/L 3compartmentss NA 50% Human Human -DTXSID6023028 Css NA 7.415 mg/L 3compartmentss NA 95% Human Human -DTXSID6023028 Css NA 0.8864 mg/L PBTK NA 50% Human Human -DTXSID6023028 Css NA 4.511 mg/L PBTK NA 95% Human Human +DTXSID6023028 TK.Half.Life NA 3.487 hours 1compartment NA NA Human Human +DTXSID6023028 Css NA 1.055 mg/L 3compartmentss NA 50% Human Human +DTXSID6023028 Css NA 6.377 mg/L 3compartmentss NA 95% Human Human +DTXSID6023028 Css NA 0.7514 mg/L PBTK NA 50% Human Human +DTXSID6023028 Css NA 3.899 mg/L PBTK NA 95% Human Human DTXSID6023028 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023028 Fup NA 0.6977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023028 Vd NA 0.4614 L/kg 1compartment NA NA Rat Human +DTXSID6023028 Vd NA 0.4035 L/kg 1compartment NA NA Rat Human DTXSID6023028 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023028 TK.Half.Life NA 1.458 hours 1compartment NA NA Rat Human -DTXSID6023028 Css NA 0.3187 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023028 Css NA 1.896 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023028 Css NA 0.2232 mg/L PBTK NA 50% Rat Human -DTXSID6023028 Css NA 1.086 mg/L PBTK NA 95% Rat Human -DTXSID6023076 Clint NA 3.873 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023076 Fup NA 0.1446 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023076 Vd NA 2.48 L/kg 1compartment NA NA Human Human -DTXSID6023076 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6023076 TK.Half.Life NA 34.5 hours 1compartment NA NA Human Human -DTXSID6023076 Css NA 1.758 mg/L 3compartmentss NA 50% Human Human -DTXSID6023076 Css NA 9.023 mg/L 3compartmentss NA 95% Human Human -DTXSID6023076 Css NA 1.237 mg/L PBTK NA 50% Human Human -DTXSID6023076 Css NA 6.068 mg/L PBTK NA 95% Human Human -DTXSID6023076 Clint NA 3.873 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023076 Fup NA 0.1446 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023076 Vd NA 1.878 L/kg 1compartment NA NA Rat Human -DTXSID6023076 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6023076 TK.Half.Life NA 8.291 hours 1compartment NA NA Rat Human -DTXSID6023076 Css NA 0.8942 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023076 Css NA 3.317 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023076 Css NA 0.6007 mg/L PBTK NA 50% Rat Human -DTXSID6023076 Css NA 2.057 mg/L PBTK NA 95% Rat Human +DTXSID6023028 TK.Half.Life NA 1.275 hours 1compartment NA NA Rat Human +DTXSID6023028 Css NA 0.02066 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023028 Css NA 0.1564 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023028 Css NA 0.0139 mg/L PBTK NA 50% Rat Human +DTXSID6023028 Css NA 0.09442 mg/L PBTK NA 95% Rat Human +DTXSID6023076 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023076 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023076 Vd NA 2.612 L/kg 1compartment NA NA Human Human +DTXSID6023076 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6023076 TK.Half.Life NA 11.69 hours 1compartment NA NA Human Human +DTXSID6023076 Css NA 0.4888 mg/L 3compartmentss NA 50% Human Human +DTXSID6023076 Css NA 3.299 mg/L 3compartmentss NA 95% Human Human +DTXSID6023076 Css NA 0.3372 mg/L PBTK NA 50% Human Human +DTXSID6023076 Css NA 2.193 mg/L PBTK NA 95% Human Human +DTXSID6023076 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023076 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023076 Vd NA 1.971 L/kg 1compartment NA NA Rat Human +DTXSID6023076 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6023076 TK.Half.Life NA 2.887 hours 1compartment NA NA Rat Human +DTXSID6023076 Css NA 0.06263 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023076 Css NA 0.3259 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023076 Css NA 0.0428 mg/L PBTK NA 50% Rat Human +DTXSID6023076 Css NA 0.2191 mg/L PBTK NA 95% Rat Human DTXSID6023078 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023078 Fup NA 0.5921 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023078 Vd NA 0.5809 L/kg 1compartment NA NA Human Human +DTXSID6023078 Vd NA 0.5678 L/kg 1compartment NA NA Human Human DTXSID6023078 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023078 TK.Half.Life NA 6.348 hours 1compartment NA NA Human Human -DTXSID6023078 Css NA 1.284 mg/L 3compartmentss NA 50% Human Human -DTXSID6023078 Css NA 8.563 mg/L 3compartmentss NA 95% Human Human -DTXSID6023078 Css NA 0.994 mg/L PBTK NA 50% Human Human -DTXSID6023078 Css NA 5.309 mg/L PBTK NA 95% Human Human +DTXSID6023078 TK.Half.Life NA 6.205 hours 1compartment NA NA Human Human +DTXSID6023078 Css NA 1.088 mg/L 3compartmentss NA 50% Human Human +DTXSID6023078 Css NA 7.425 mg/L 3compartmentss NA 95% Human Human +DTXSID6023078 Css NA 0.8448 mg/L PBTK NA 50% Human Human +DTXSID6023078 Css NA 4.664 mg/L PBTK NA 95% Human Human DTXSID6023078 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023078 Fup NA 0.5921 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023078 Vd NA 0.6075 L/kg 1compartment NA NA Rat Human +DTXSID6023078 Vd NA 0.5958 L/kg 1compartment NA NA Rat Human DTXSID6023078 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023078 TK.Half.Life NA 2.263 hours 1compartment NA NA Rat Human -DTXSID6023078 Css NA 0.3362 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023078 Css NA 2.108 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023078 Css NA 0.2503 mg/L PBTK NA 50% Rat Human -DTXSID6023078 Css NA 1.226 mg/L PBTK NA 95% Rat Human -DTXSID6023101 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023101 Fup NA 0.9431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023101 Vd NA 0.6182 L/kg 1compartment NA NA Human Human +DTXSID6023078 TK.Half.Life NA 2.219 hours 1compartment NA NA Rat Human +DTXSID6023078 Css NA 0.02053 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023078 Css NA 0.1825 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023078 Css NA 0.01526 mg/L PBTK NA 50% Rat Human +DTXSID6023078 Css NA 0.1114 mg/L PBTK NA 95% Rat Human +DTXSID60230861 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60230861 Fup 0.553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60230861 Vd NA 1.557 L/kg 1compartment NA NA Human Human +DTXSID60230861 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60230861 TK.Half.Life NA 2.247 hours 1compartment NA NA Human Human +DTXSID60230861 Css NA 0.0964 mg/L 3compartmentss NA 50% Human Human +DTXSID60230861 Css NA 0.9353 mg/L 3compartmentss NA 95% Human Human +DTXSID60230861 Css NA 0.08942 mg/L PBTK NA 50% Human Human +DTXSID60230861 Css NA 0.6684 mg/L PBTK NA 95% Human Human +DTXSID60230861 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60230861 Fup 0.553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60230861 Vd NA 2.012 L/kg 1compartment NA NA Rat Human +DTXSID60230861 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60230861 TK.Half.Life NA 1.142 hours 1compartment NA NA Rat Human +DTXSID60230861 Css NA 0.00732 mg/L 3compartmentss NA 50% Rat Human +DTXSID60230861 Css NA 0.06176 mg/L 3compartmentss NA 95% Rat Human +DTXSID60230861 Css NA 0.007814 mg/L PBTK NA 50% Rat Human +DTXSID60230861 Css NA 0.04487 mg/L PBTK NA 95% Rat Human +DTXSID6023101 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023101 Fup 0.711 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023101 Vd NA 0.4986 L/kg 1compartment NA NA Human Human DTXSID6023101 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023101 TK.Half.Life NA 4.242 hours 1compartment NA NA Human Human -DTXSID6023101 Css NA 0.9385 mg/L 3compartmentss NA 50% Human Human -DTXSID6023101 Css NA 5.162 mg/L 3compartmentss NA 95% Human Human -DTXSID6023101 Css NA 0.751 mg/L PBTK NA 50% Human Human -DTXSID6023101 Css NA 3.369 mg/L PBTK NA 95% Human Human -DTXSID6023101 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023101 Fup NA 0.9431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023101 Vd NA 0.6587 L/kg 1compartment NA NA Rat Human +DTXSID6023101 TK.Half.Life NA 4.536 hours 1compartment NA NA Human Human +DTXSID6023101 Css NA 0.6192 mg/L 3compartmentss NA 50% Human Human +DTXSID6023101 Css NA 3.903 mg/L 3compartmentss NA 95% Human Human +DTXSID6023101 Css NA 0.4734 mg/L PBTK NA 50% Human Human +DTXSID6023101 Css NA 2.414 mg/L PBTK NA 95% Human Human +DTXSID6023101 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023101 Fup 0.711 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023101 Vd NA 0.5371 L/kg 1compartment NA NA Rat Human DTXSID6023101 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023101 TK.Half.Life NA 1.54 hours 1compartment NA NA Rat Human -DTXSID6023101 Css NA 0.2389 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023101 Css NA 1.274 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023101 Css NA 0.1855 mg/L PBTK NA 50% Rat Human -DTXSID6023101 Css NA 0.7613 mg/L PBTK NA 95% Rat Human -DTXSID6023103 Clint NA 1.535 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023103 Fup NA 0.0181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023103 Vd NA 0.2009 L/kg 1compartment NA NA Human Human -DTXSID6023103 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6023103 TK.Half.Life NA 20.36 hours 1compartment NA NA Human Human -DTXSID6023103 Css NA 18.08 mg/L 3compartmentss NA 50% Human Human -DTXSID6023103 Css NA 124.5 mg/L 3compartmentss NA 95% Human Human -DTXSID6023103 Css NA 10.7 mg/L PBTK NA 50% Human Human -DTXSID6023103 Css NA 71.95 mg/L PBTK NA 95% Human Human -DTXSID6023103 Clint NA 1.535 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023103 Fup NA 0.0181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023103 Vd NA 0.1962 L/kg 1compartment NA NA Rat Human -DTXSID6023103 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6023103 TK.Half.Life NA 10.72 hours 1compartment NA NA Rat Human -DTXSID6023103 Css NA 8.163 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023103 Css NA 48.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023103 Css NA 4.487 mg/L PBTK NA 50% Rat Human -DTXSID6023103 Css NA 26.45 mg/L PBTK NA 95% Rat Human -DTXSID6023109 Clint NA 20.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023109 Fup NA 0.9722 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023109 Vd NA 5.459 L/kg 1compartment NA NA Human Human +DTXSID6023101 TK.Half.Life NA 1.666 hours 1compartment NA NA Rat Human +DTXSID6023101 Css NA 0.003256 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023101 Css NA 0.02152 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023101 Css NA 0.002394 mg/L PBTK NA 50% Rat Human +DTXSID6023101 Css NA 0.01297 mg/L PBTK NA 95% Rat Human +DTXSID6023103 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023103 Fup 0.0565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023103 Vd NA 0.2746 L/kg 1compartment NA NA Human Human +DTXSID6023103 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6023103 TK.Half.Life NA 1.091 hours 1compartment NA NA Human Human +DTXSID6023103 Css NA 0.5431 mg/L 3compartmentss NA 50% Human Human +DTXSID6023103 Css NA 4.432 mg/L 3compartmentss NA 95% Human Human +DTXSID6023103 Css NA 0.3308 mg/L PBTK NA 50% Human Human +DTXSID6023103 Css NA 2.63 mg/L PBTK NA 95% Human Human +DTXSID6023103 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023103 Fup 0.0565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023103 Vd NA 0.2673 L/kg 1compartment NA NA Rat Human +DTXSID6023103 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6023103 TK.Half.Life NA 0.662 hours 1compartment NA NA Rat Human +DTXSID6023103 Css NA 0.07087 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023103 Css NA 0.4507 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023103 Css NA 0.04207 mg/L PBTK NA 50% Rat Human +DTXSID6023103 Css NA 0.2609 mg/L PBTK NA 95% Rat Human +DTXSID6023109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023109 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023109 Vd NA 2.397 L/kg 1compartment NA NA Human Human DTXSID6023109 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023109 TK.Half.Life NA 3.49 hours 1compartment NA NA Human Human -DTXSID6023109 Css NA 0.02083 mg/L 3compartmentss NA 50% Human Human -DTXSID6023109 Css NA 0.2212 mg/L 3compartmentss NA 95% Human Human -DTXSID6023109 Css NA 0.03006 mg/L PBTK NA 50% Human Human -DTXSID6023109 Css NA 0.2343 mg/L PBTK NA 95% Human Human -DTXSID6023109 Clint NA 20.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023109 Fup NA 0.9722 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023109 Vd NA 5.28 L/kg 1compartment NA NA Rat Human +DTXSID6023109 TK.Half.Life NA 2.51 hours 1compartment NA NA Human Human +DTXSID6023109 Css NA 0.04475 mg/L 3compartmentss NA 50% Human Human +DTXSID6023109 Css NA 0.3765 mg/L 3compartmentss NA 95% Human Human +DTXSID6023109 Css NA 0.04304 mg/L PBTK NA 50% Human Human +DTXSID6023109 Css NA 0.3036 mg/L PBTK NA 95% Human Human +DTXSID6023109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023109 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023109 Vd NA 2.375 L/kg 1compartment NA NA Rat Human DTXSID6023109 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023109 TK.Half.Life NA 1.424 hours 1compartment NA NA Rat Human -DTXSID6023109 Css NA 0.0104 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023109 Css NA 0.09608 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023109 Css NA 0.01533 mg/L PBTK NA 50% Rat Human -DTXSID6023109 Css NA 0.09704 mg/L PBTK NA 95% Rat Human +DTXSID6023109 TK.Half.Life NA 1.327 hours 1compartment NA NA Rat Human +DTXSID6023109 Css NA 0.005446 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023109 Css NA 0.0366 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023109 Css NA 0.005362 mg/L PBTK NA 50% Rat Human +DTXSID6023109 Css NA 0.02903 mg/L PBTK NA 95% Rat Human DTXSID6023153 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023153 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023153 Vd NA 0.2095 L/kg 1compartment NA NA Human Human -DTXSID6023153 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID6023153 TK.Half.Life NA 101.1 hours 1compartment NA NA Human Human -DTXSID6023153 Css NA 82.31 mg/L 3compartmentss NA 50% Human Human -DTXSID6023153 Css NA 523.5 mg/L 3compartmentss NA 95% Human Human -DTXSID6023153 Css NA 48.74 mg/L PBTK NA 50% Human Human -DTXSID6023153 Css NA 299.3 mg/L PBTK NA 95% Human Human +DTXSID6023153 Vd NA 0.2745 L/kg 1compartment NA NA Human Human +DTXSID6023153 Days.Css NA 29 Days PBTK NA NA Human Human +DTXSID6023153 TK.Half.Life NA 132.7 hours 1compartment NA NA Human Human +DTXSID6023153 Css NA 69.37 mg/L 3compartmentss NA 50% Human Human +DTXSID6023153 Css NA 441.1 mg/L 3compartmentss NA 95% Human Human +DTXSID6023153 Css NA 41.4 mg/L PBTK NA 50% Human Human +DTXSID6023153 Css NA 254.9 mg/L PBTK NA 95% Human Human DTXSID6023153 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023153 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023153 Vd NA 0.2043 L/kg 1compartment NA NA Rat Human -DTXSID6023153 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID6023153 TK.Half.Life NA 33.62 hours 1compartment NA NA Rat Human -DTXSID6023153 Css NA 23.55 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023153 Css NA 130.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023153 Css NA 12.94 mg/L PBTK NA 50% Rat Human -DTXSID6023153 Css NA 70.58 mg/L PBTK NA 95% Rat Human +DTXSID6023153 Vd NA 0.2598 L/kg 1compartment NA NA Rat Human +DTXSID6023153 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID6023153 TK.Half.Life NA 42.79 hours 1compartment NA NA Rat Human +DTXSID6023153 Css NA 1.311 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023153 Css NA 11.08 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023153 Css NA 0.7474 mg/L PBTK NA 50% Rat Human +DTXSID6023153 Css NA 6.183 mg/L PBTK NA 95% Rat Human DTXSID6023155 Clint NA 0.8614 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023155 Fup NA 0.0363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023155 Vd NA 1.809 L/kg 1compartment NA NA Human Human -DTXSID6023155 Days.Css NA 36 Days PBTK NA NA Human Human -DTXSID6023155 TK.Half.Life NA 176.4 hours 1compartment NA NA Human Human -DTXSID6023155 Css NA 15.42 mg/L 3compartmentss NA 50% Human Human -DTXSID6023155 Css NA 70.46 mg/L 3compartmentss NA 95% Human Human -DTXSID6023155 Css NA 9.909 mg/L PBTK NA 50% Human Human -DTXSID6023155 Css NA 42.4 mg/L PBTK NA 95% Human Human +DTXSID6023155 Vd NA 2.437 L/kg 1compartment NA NA Human Human +DTXSID6023155 Days.Css NA 79 Days PBTK NA NA Human Human +DTXSID6023155 TK.Half.Life NA 348.1 hours 1compartment NA NA Human Human +DTXSID6023155 Css NA 20.07 mg/L 3compartmentss NA 50% Human Human +DTXSID6023155 Css NA 82.11 mg/L 3compartmentss NA 95% Human Human +DTXSID6023155 Css NA 13.27 mg/L PBTK NA 50% Human Human +DTXSID6023155 Css NA 51.02 mg/L PBTK NA 95% Human Human DTXSID6023155 Clint NA 0.8614 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023155 Fup NA 0.0363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023155 Vd NA 1.349 L/kg 1compartment NA NA Rat Human -DTXSID6023155 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID6023155 TK.Half.Life NA 47.28 hours 1compartment NA NA Rat Human -DTXSID6023155 Css NA 6.701 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023155 Css NA 23.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023155 Css NA 4.04 mg/L PBTK NA 50% Rat Human -DTXSID6023155 Css NA 13.2 mg/L PBTK NA 95% Rat Human +DTXSID6023155 Vd NA 1.821 L/kg 1compartment NA NA Rat Human +DTXSID6023155 Days.Css NA 32 Days PBTK NA NA Rat Human +DTXSID6023155 TK.Half.Life NA 70.01 hours 1compartment NA NA Rat Human +DTXSID6023155 Css NA 2.05 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023155 Css NA 6.34 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023155 Css NA 1.34 mg/L PBTK NA 50% Rat Human +DTXSID6023155 Css NA 3.837 mg/L PBTK NA 95% Rat Human DTXSID6023157 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023157 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6023157 Vd NA 0.4876 L/kg 1compartment NA NA Human Human DTXSID6023157 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023157 TK.Half.Life NA 3.156 hours 1compartment NA NA Human Human -DTXSID6023157 Css NA 0.9331 mg/L 3compartmentss NA 50% Human Human -DTXSID6023157 Css NA 5.729 mg/L 3compartmentss NA 95% Human Human -DTXSID6023157 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID6023157 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID6023157 Css NA 0.5104 mg/L 3compartmentss NA 50% Human Human +DTXSID6023157 Css NA 3.14 mg/L 3compartmentss NA 95% Human Human +DTXSID6023157 Css NA 0.3817 mg/L PBTK NA 50% Human Human +DTXSID6023157 Css NA 1.998 mg/L PBTK NA 95% Human Human DTXSID6023157 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023157 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6023157 Vd NA 0.5246 L/kg 1compartment NA NA Rat Human DTXSID6023157 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023157 TK.Half.Life NA 1.157 hours 1compartment NA NA Rat Human -DTXSID6023157 Css NA 0.2372 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023157 Css NA 1.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023157 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID6023157 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID6023157 Css NA 0.002579 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023157 Css NA 0.01785 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023157 Css NA 0.001866 mg/L PBTK NA 50% Rat Human +DTXSID6023157 Css NA 0.01062 mg/L PBTK NA 95% Rat Human DTXSID6023159 Clint NA 0.3846 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023159 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023159 Vd NA 0.2501 L/kg 1compartment NA NA Human Human -DTXSID6023159 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID6023159 TK.Half.Life NA 67.1 hours 1compartment NA NA Human Human -DTXSID6023159 Css NA 45.11 mg/L 3compartmentss NA 50% Human Human -DTXSID6023159 Css NA 299.7 mg/L 3compartmentss NA 95% Human Human -DTXSID6023159 Css NA 26.98 mg/L PBTK NA 50% Human Human -DTXSID6023159 Css NA 174.3 mg/L PBTK NA 95% Human Human +DTXSID6023159 Vd NA 0.2318 L/kg 1compartment NA NA Human Human +DTXSID6023159 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID6023159 TK.Half.Life NA 62.28 hours 1compartment NA NA Human Human +DTXSID6023159 Css NA 38.7 mg/L 3compartmentss NA 50% Human Human +DTXSID6023159 Css NA 259.2 mg/L 3compartmentss NA 95% Human Human +DTXSID6023159 Css NA 22.97 mg/L PBTK NA 50% Human Human +DTXSID6023159 Css NA 151 mg/L PBTK NA 95% Human Human DTXSID6023159 Clint NA 0.3846 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023159 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023159 Vd NA 0.2414 L/kg 1compartment NA NA Rat Human +DTXSID6023159 Vd NA 0.2253 L/kg 1compartment NA NA Rat Human DTXSID6023159 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID6023159 TK.Half.Life NA 27.62 hours 1compartment NA NA Rat Human -DTXSID6023159 Css NA 16.25 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023159 Css NA 95.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023159 Css NA 9.048 mg/L PBTK NA 50% Rat Human -DTXSID6023159 Css NA 51.93 mg/L PBTK NA 95% Rat Human +DTXSID6023159 TK.Half.Life NA 25.81 hours 1compartment NA NA Rat Human +DTXSID6023159 Css NA 1.232 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023159 Css NA 10.17 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023159 Css NA 0.6984 mg/L PBTK NA 50% Rat Human +DTXSID6023159 Css NA 5.679 mg/L PBTK NA 95% Rat Human DTXSID6023232 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023232 Fup NA 0.9713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023232 Vd NA 1.336 L/kg 1compartment NA NA Human Human +DTXSID6023232 Vd NA 0.6602 L/kg 1compartment NA NA Human Human DTXSID6023232 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023232 TK.Half.Life NA 8.896 hours 1compartment NA NA Human Human -DTXSID6023232 Css NA 0.7768 mg/L 3compartmentss NA 50% Human Human -DTXSID6023232 Css NA 4.814 mg/L 3compartmentss NA 95% Human Human -DTXSID6023232 Css NA 0.7362 mg/L PBTK NA 50% Human Human -DTXSID6023232 Css NA 3.303 mg/L PBTK NA 95% Human Human +DTXSID6023232 TK.Half.Life NA 4.395 hours 1compartment NA NA Human Human +DTXSID6023232 Css NA 0.777 mg/L 3compartmentss NA 50% Human Human +DTXSID6023232 Css NA 4.324 mg/L 3compartmentss NA 95% Human Human +DTXSID6023232 Css NA 0.6286 mg/L PBTK NA 50% Human Human +DTXSID6023232 Css NA 2.801 mg/L PBTK NA 95% Human Human DTXSID6023232 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023232 Fup NA 0.9713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023232 Vd NA 1.4 L/kg 1compartment NA NA Rat Human +DTXSID6023232 Vd NA 0.7136 L/kg 1compartment NA NA Rat Human DTXSID6023232 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023232 TK.Half.Life NA 3.178 hours 1compartment NA NA Rat Human -DTXSID6023232 Css NA 0.1952 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023232 Css NA 1.178 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023232 Css NA 0.1821 mg/L PBTK NA 50% Rat Human -DTXSID6023232 Css NA 0.7488 mg/L PBTK NA 95% Rat Human -DTXSID6023280 Clint NA 1.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023280 Fup NA 0.6295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023280 Vd NA 1.129 L/kg 1compartment NA NA Human Human -DTXSID6023280 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023280 TK.Half.Life NA 4.188 hours 1compartment NA NA Human Human -DTXSID6023280 Css NA 0.3727 mg/L 3compartmentss NA 50% Human Human -DTXSID6023280 Css NA 2.791 mg/L 3compartmentss NA 95% Human Human -DTXSID6023280 Css NA 0.3167 mg/L PBTK NA 50% Human Human -DTXSID6023280 Css NA 1.829 mg/L PBTK NA 95% Human Human -DTXSID6023280 Clint NA 1.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023280 Fup NA 0.6295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023280 Vd NA 1.036 L/kg 1compartment NA NA Rat Human +DTXSID6023232 TK.Half.Life NA 1.62 hours 1compartment NA NA Rat Human +DTXSID6023232 Css NA 0.01422 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023232 Css NA 0.1029 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023232 Css NA 0.01107 mg/L PBTK NA 50% Rat Human +DTXSID6023232 Css NA 0.06833 mg/L PBTK NA 95% Rat Human +DTXSID6023280 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023280 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023280 Vd NA 1.188 L/kg 1compartment NA NA Human Human +DTXSID6023280 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6023280 TK.Half.Life NA 12 hours 1compartment NA NA Human Human +DTXSID6023280 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human +DTXSID6023280 Css NA 7.059 mg/L 3compartmentss NA 95% Human Human +DTXSID6023280 Css NA 0.9085 mg/L PBTK NA 50% Human Human +DTXSID6023280 Css NA 4.532 mg/L PBTK NA 95% Human Human +DTXSID6023280 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023280 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023280 Vd NA 1.09 L/kg 1compartment NA NA Rat Human DTXSID6023280 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023280 TK.Half.Life NA 1.855 hours 1compartment NA NA Rat Human -DTXSID6023280 Css NA 0.149 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023280 Css NA 1.042 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023280 Css NA 0.125 mg/L PBTK NA 50% Rat Human -DTXSID6023280 Css NA 0.634 mg/L PBTK NA 95% Rat Human -DTXSID6023286 Clint NA 199.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023286 Fup NA 0.4787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023286 Vd NA 0.4838 L/kg 1compartment NA NA Human Human +DTXSID6023280 TK.Half.Life NA 3.562 hours 1compartment NA NA Rat Human +DTXSID6023280 Css NA 0.06137 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023280 Css NA 0.3998 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023280 Css NA 0.05426 mg/L PBTK NA 50% Rat Human +DTXSID6023280 Css NA 0.2514 mg/L PBTK NA 95% Rat Human +DTXSID6023284 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023284 Fup 0.43 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6023284 Vd NA 0.5827 L/kg 1compartment NA NA Human Human +DTXSID6023284 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6023284 TK.Half.Life NA 1.135 hours 1compartment NA NA Human Human +DTXSID6023284 Css NA 0.1327 mg/L 3compartmentss NA 50% Human Human +DTXSID6023284 Css NA 0.999 mg/L 3compartmentss NA 95% Human Human +DTXSID6023284 Css NA 0.09637 mg/L PBTK NA 50% Human Human +DTXSID6023284 Css NA 0.6504 mg/L PBTK NA 95% Human Human +DTXSID6023284 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023284 Fup 0.43 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6023284 Vd NA 0.5549 L/kg 1compartment NA NA Rat Human +DTXSID6023284 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6023284 TK.Half.Life NA 0.595 hours 1compartment NA NA Rat Human +DTXSID6023284 Css NA 0.005856 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023284 Css NA 0.04876 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023284 Css NA 0.004269 mg/L PBTK NA 50% Rat Human +DTXSID6023284 Css NA 0.03165 mg/L PBTK NA 95% Rat Human +DTXSID6023286 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023286 Fup 0.676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023286 Vd NA 0.5838 L/kg 1compartment NA NA Human Human DTXSID6023286 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023286 TK.Half.Life NA 0.3759 hours 1compartment NA NA Human Human -DTXSID6023286 Css NA 0.005166 mg/L 3compartmentss NA 50% Human Human -DTXSID6023286 Css NA 0.0466 mg/L 3compartmentss NA 95% Human Human -DTXSID6023286 Css NA 0.003698 mg/L PBTK NA 50% Human Human -DTXSID6023286 Css NA 0.03024 mg/L PBTK NA 95% Human Human -DTXSID6023286 Clint NA 199.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023286 Fup NA 0.4787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023286 Vd NA 0.4829 L/kg 1compartment NA NA Rat Human +DTXSID6023286 TK.Half.Life NA 5.608 hours 1compartment NA NA Human Human +DTXSID6023286 Css NA 1.149 mg/L 3compartmentss NA 50% Human Human +DTXSID6023286 Css NA 7.068 mg/L 3compartmentss NA 95% Human Human +DTXSID6023286 Css NA 0.8832 mg/L PBTK NA 50% Human Human +DTXSID6023286 Css NA 4.417 mg/L PBTK NA 95% Human Human +DTXSID6023286 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023286 Fup 0.676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023286 Vd NA 0.5842 L/kg 1compartment NA NA Rat Human DTXSID6023286 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023286 TK.Half.Life NA 0.1665 hours 1compartment NA NA Rat Human -DTXSID6023286 Css NA 0.002804 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023286 Css NA 0.02143 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023286 Css NA 0.001936 mg/L PBTK NA 50% Rat Human -DTXSID6023286 Css NA 0.01344 mg/L PBTK NA 95% Rat Human -DTXSID6023313 Clint NA 7.823 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023313 Fup NA 0.1616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023313 Vd NA 0.6212 L/kg 1compartment NA NA Human Human +DTXSID6023286 TK.Half.Life NA 1.907 hours 1compartment NA NA Rat Human +DTXSID6023286 Css NA 0.06923 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023286 Css NA 0.4248 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023286 Css NA 0.0527 mg/L PBTK NA 50% Rat Human +DTXSID6023286 Css NA 0.2554 mg/L PBTK NA 95% Rat Human +DTXSID6023313 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023313 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023313 Vd NA 0.7396 L/kg 1compartment NA NA Human Human DTXSID6023313 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023313 TK.Half.Life NA 2.233 hours 1compartment NA NA Human Human -DTXSID6023313 Css NA 0.4049 mg/L 3compartmentss NA 50% Human Human -DTXSID6023313 Css NA 2.673 mg/L 3compartmentss NA 95% Human Human -DTXSID6023313 Css NA 0.2665 mg/L PBTK NA 50% Human Human -DTXSID6023313 Css NA 1.63 mg/L PBTK NA 95% Human Human -DTXSID6023313 Clint NA 7.823 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023313 Fup NA 0.1616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023313 Vd NA 0.545 L/kg 1compartment NA NA Rat Human +DTXSID6023313 TK.Half.Life NA 2.413 hours 1compartment NA NA Human Human +DTXSID6023313 Css NA 0.3189 mg/L 3compartmentss NA 50% Human Human +DTXSID6023313 Css NA 1.796 mg/L 3compartmentss NA 95% Human Human +DTXSID6023313 Css NA 0.221 mg/L PBTK NA 50% Human Human +DTXSID6023313 Css NA 1.17 mg/L PBTK NA 95% Human Human +DTXSID6023313 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023313 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023313 Vd NA 0.6497 L/kg 1compartment NA NA Rat Human DTXSID6023313 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023313 TK.Half.Life NA 1.149 hours 1compartment NA NA Rat Human -DTXSID6023313 Css NA 0.2158 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023313 Css NA 1.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023313 Css NA 0.1352 mg/L PBTK NA 50% Rat Human -DTXSID6023313 Css NA 0.6113 mg/L PBTK NA 95% Rat Human -DTXSID6023315 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023315 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023315 Vd NA 0.7165 L/kg 1compartment NA NA Human Human +DTXSID6023313 TK.Half.Life NA 1.211 hours 1compartment NA NA Rat Human +DTXSID6023313 Css NA 0.0371 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023313 Css NA 0.1625 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023313 Css NA 0.02562 mg/L PBTK NA 50% Rat Human +DTXSID6023313 Css NA 0.1028 mg/L PBTK NA 95% Rat Human +DTXSID6023315 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023315 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023315 Vd NA 0.4457 L/kg 1compartment NA NA Human Human DTXSID6023315 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023315 TK.Half.Life NA 4.636 hours 1compartment NA NA Human Human -DTXSID6023315 Css NA 0.8441 mg/L 3compartmentss NA 50% Human Human -DTXSID6023315 Css NA 5.537 mg/L 3compartmentss NA 95% Human Human -DTXSID6023315 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID6023315 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID6023315 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023315 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023315 Vd NA 0.762 L/kg 1compartment NA NA Rat Human +DTXSID6023315 TK.Half.Life NA 5.501 hours 1compartment NA NA Human Human +DTXSID6023315 Css NA 1.417 mg/L 3compartmentss NA 50% Human Human +DTXSID6023315 Css NA 7.684 mg/L 3compartmentss NA 95% Human Human +DTXSID6023315 Css NA 1.045 mg/L PBTK NA 50% Human Human +DTXSID6023315 Css NA 4.76 mg/L PBTK NA 95% Human Human +DTXSID6023315 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023315 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023315 Vd NA 0.4738 L/kg 1compartment NA NA Rat Human DTXSID6023315 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023315 TK.Half.Life NA 1.68 hours 1compartment NA NA Rat Human -DTXSID6023315 Css NA 0.2121 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023315 Css NA 1.315 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023315 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID6023315 Css NA 0.7874 mg/L PBTK NA 95% Rat Human +DTXSID6023315 TK.Half.Life NA 1.994 hours 1compartment NA NA Rat Human +DTXSID6023315 Css NA 0.08896 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023315 Css NA 0.4368 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023315 Css NA 0.06435 mg/L PBTK NA 50% Rat Human +DTXSID6023315 Css NA 0.2618 mg/L PBTK NA 95% Rat Human DTXSID6023317 Clint 5.841 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6023317 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6023317 Vd NA 2.732 L/kg 1compartment NA NA Human Human -DTXSID6023317 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6023317 TK.Half.Life NA 31.52 hours 1compartment NA NA Human Human -DTXSID6023317 Css NA 1.517 mg/L 3compartmentss NA 50% Human Human -DTXSID6023317 Css NA 10.09 mg/L 3compartmentss NA 95% Human Human -DTXSID6023317 Css NA 1.11 mg/L PBTK NA 50% Human Human -DTXSID6023317 Css NA 6.921 mg/L PBTK NA 95% Human Human +DTXSID6023317 Vd NA 2.848 L/kg 1compartment NA NA Human Human +DTXSID6023317 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID6023317 TK.Half.Life NA 35.31 hours 1compartment NA NA Human Human +DTXSID6023317 Css NA 1.546 mg/L 3compartmentss NA 50% Human Human +DTXSID6023317 Css NA 10.77 mg/L 3compartmentss NA 95% Human Human +DTXSID6023317 Css NA 1.132 mg/L PBTK NA 50% Human Human +DTXSID6023317 Css NA 7.267 mg/L PBTK NA 95% Human Human DTXSID6023317 Clint 5.841 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID6023317 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6023317 Vd NA 2.239 L/kg 1compartment NA NA Rat Human +DTXSID6023317 Vd NA 2.3 L/kg 1compartment NA NA Rat Human DTXSID6023317 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6023317 TK.Half.Life NA 10.13 hours 1compartment NA NA Rat Human -DTXSID6023317 Css NA 0.8102 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023317 Css NA 4.347 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023317 Css NA 0.5699 mg/L PBTK NA 50% Rat Human -DTXSID6023317 Css NA 2.759 mg/L PBTK NA 95% Rat Human -DTXSID6023319 Clint NA 23.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6023317 TK.Half.Life NA 10.12 hours 1compartment NA NA Rat Human +DTXSID6023317 Css NA 0.1948 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023317 Css NA 0.9952 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023317 Css NA 0.1412 mg/L PBTK NA 50% Rat Human +DTXSID6023317 Css NA 0.6672 mg/L PBTK NA 95% Rat Human +DTXSID6023319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6023319 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6023319 Vd NA 3.444 L/kg 1compartment NA NA Human Human -DTXSID6023319 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6023319 TK.Half.Life NA 32.19 hours 1compartment NA NA Human Human -DTXSID6023319 Css NA 0.9082 mg/L 3compartmentss NA 50% Human Human -DTXSID6023319 Css NA 6.058 mg/L 3compartmentss NA 95% Human Human -DTXSID6023319 Css NA 0.7822 mg/L PBTK NA 50% Human Human -DTXSID6023319 Css NA 4.933 mg/L PBTK NA 95% Human Human -DTXSID6023319 Clint NA 23.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6023319 Vd NA 3.666 L/kg 1compartment NA NA Human Human +DTXSID6023319 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID6023319 TK.Half.Life NA 109 hours 1compartment NA NA Human Human +DTXSID6023319 Css NA 3.224 mg/L 3compartmentss NA 50% Human Human +DTXSID6023319 Css NA 18.99 mg/L 3compartmentss NA 95% Human Human +DTXSID6023319 Css NA 2.343 mg/L PBTK NA 50% Human Human +DTXSID6023319 Css NA 13.61 mg/L PBTK NA 95% Human Human +DTXSID6023319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6023319 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6023319 Vd NA 2.763 L/kg 1compartment NA NA Rat Human -DTXSID6023319 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6023319 TK.Half.Life NA 5.884 hours 1compartment NA NA Rat Human -DTXSID6023319 Css NA 0.4986 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023319 Css NA 2.655 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023319 Css NA 0.4204 mg/L PBTK NA 50% Rat Human -DTXSID6023319 Css NA 2.091 mg/L PBTK NA 95% Rat Human +DTXSID6023319 Vd NA 2.767 L/kg 1compartment NA NA Rat Human +DTXSID6023319 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID6023319 TK.Half.Life NA 14.42 hours 1compartment NA NA Rat Human +DTXSID6023319 Css NA 0.4254 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023319 Css NA 2.119 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023319 Css NA 0.307 mg/L PBTK NA 50% Rat Human +DTXSID6023319 Css NA 1.532 mg/L PBTK NA 95% Rat Human DTXSID6023363 Clint 402 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.105.0042595 NA Human Human DTXSID6023363 Fup 0.084 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID6023363 Vd NA 2.78 L/kg 1compartment NA NA Human Human DTXSID6023363 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023363 TK.Half.Life NA 2.854 hours 1compartment NA NA Human Human -DTXSID6023363 Css NA 0.03832 mg/L 3compartmentss NA 50% Human Human -DTXSID6023363 Css NA 0.2705 mg/L 3compartmentss NA 95% Human Human -DTXSID6023363 Css NA 0.02368 mg/L PBTK NA 50% Human Human -DTXSID6023363 Css NA 0.1645 mg/L PBTK NA 95% Human Human +DTXSID6023363 Css NA 0.03001 mg/L 3compartmentss NA 50% Human Human +DTXSID6023363 Css NA 0.22 mg/L 3compartmentss NA 95% Human Human +DTXSID6023363 Css NA 0.0213 mg/L PBTK NA 50% Human Human +DTXSID6023363 Css NA 0.1562 mg/L PBTK NA 95% Human Human DTXSID6023363 Clint 402 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.105.0042595 NA Rat Human DTXSID6023363 Fup 0.084 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID6023363 Vd NA 2.167 L/kg 1compartment NA NA Rat Human DTXSID6023363 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023363 TK.Half.Life NA 0.9087 hours 1compartment NA NA Rat Human -DTXSID6023363 Css NA 0.022 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023363 Css NA 0.1214 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023363 Css NA 0.01278 mg/L PBTK NA 50% Rat Human -DTXSID6023363 Css NA 0.0693 mg/L PBTK NA 95% Rat Human -DTXSID6023365 Clint NA 885.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023365 Fup NA 0.0557 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023365 Vd NA 0.3848 L/kg 1compartment NA NA Human Human +DTXSID6023363 Css NA 0.00385 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023363 Css NA 0.02188 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023363 Css NA 0.002837 mg/L PBTK NA 50% Rat Human +DTXSID6023363 Css NA 0.01609 mg/L PBTK NA 95% Rat Human +DTXSID6023365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023365 Fup 0.0827 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023365 Vd NA 0.7633 L/kg 1compartment NA NA Human Human DTXSID6023365 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023365 TK.Half.Life NA 0.3709 hours 1compartment NA NA Human Human -DTXSID6023365 Css NA 0.01364 mg/L 3compartmentss NA 50% Human Human -DTXSID6023365 Css NA 0.1246 mg/L 3compartmentss NA 95% Human Human -DTXSID6023365 Css NA 0.008712 mg/L PBTK NA 50% Human Human -DTXSID6023365 Css NA 0.07608 mg/L PBTK NA 95% Human Human -DTXSID6023365 Clint NA 885.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023365 Fup NA 0.0557 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023365 Vd NA 0.3739 L/kg 1compartment NA NA Rat Human +DTXSID6023365 TK.Half.Life NA 2.135 hours 1compartment NA NA Human Human +DTXSID6023365 Css NA 0.2626 mg/L 3compartmentss NA 50% Human Human +DTXSID6023365 Css NA 2.241 mg/L 3compartmentss NA 95% Human Human +DTXSID6023365 Css NA 0.1896 mg/L PBTK NA 50% Human Human +DTXSID6023365 Css NA 1.481 mg/L PBTK NA 95% Human Human +DTXSID6023365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023365 Fup 0.0827 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023365 Vd NA 0.7312 L/kg 1compartment NA NA Rat Human DTXSID6023365 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023365 TK.Half.Life NA 0.1653 hours 1compartment NA NA Rat Human -DTXSID6023365 Css NA 0.008037 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023365 Css NA 0.05715 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023365 Css NA 0.004766 mg/L PBTK NA 50% Rat Human -DTXSID6023365 Css NA 0.03205 mg/L PBTK NA 95% Rat Human -DTXSID6023367 Clint NA 0.9691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023367 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023367 Vd NA 0.9538 L/kg 1compartment NA NA Human Human +DTXSID6023365 TK.Half.Life NA 1.246 hours 1compartment NA NA Rat Human +DTXSID6023365 Css NA 0.01258 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023365 Css NA 0.1187 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023365 Css NA 0.009053 mg/L PBTK NA 50% Rat Human +DTXSID6023365 Css NA 0.07414 mg/L PBTK NA 95% Rat Human +DTXSID6023367 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023367 Fup 0.565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023367 Vd NA 0.6747 L/kg 1compartment NA NA Human Human DTXSID6023367 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023367 TK.Half.Life NA 2.583 hours 1compartment NA NA Human Human -DTXSID6023367 Css NA 0.3082 mg/L 3compartmentss NA 50% Human Human -DTXSID6023367 Css NA 2.247 mg/L 3compartmentss NA 95% Human Human -DTXSID6023367 Css NA 0.2695 mg/L PBTK NA 50% Human Human -DTXSID6023367 Css NA 1.516 mg/L PBTK NA 95% Human Human -DTXSID6023367 Clint NA 0.9691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023367 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023367 Vd NA 0.9667 L/kg 1compartment NA NA Rat Human +DTXSID6023367 TK.Half.Life NA 7.756 hours 1compartment NA NA Human Human +DTXSID6023367 Css NA 1.276 mg/L 3compartmentss NA 50% Human Human +DTXSID6023367 Css NA 8.467 mg/L 3compartmentss NA 95% Human Human +DTXSID6023367 Css NA 1.006 mg/L PBTK NA 50% Human Human +DTXSID6023367 Css NA 5.252 mg/L PBTK NA 95% Human Human +DTXSID6023367 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023367 Fup 0.565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023367 Vd NA 0.6821 L/kg 1compartment NA NA Rat Human DTXSID6023367 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023367 TK.Half.Life NA 1.245 hours 1compartment NA NA Rat Human -DTXSID6023367 Css NA 0.1132 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023367 Css NA 0.7831 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023367 Css NA 0.09846 mg/L PBTK NA 50% Rat Human -DTXSID6023367 Css NA 0.4839 mg/L PBTK NA 95% Rat Human -DTXSID6023369 Clint NA 4.071 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023369 Fup NA 0.1404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023369 Vd NA 1.059 L/kg 1compartment NA NA Human Human +DTXSID6023367 TK.Half.Life NA 2.664 hours 1compartment NA NA Rat Human +DTXSID6023367 Css NA 0.07803 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023367 Css NA 0.4997 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023367 Css NA 0.06104 mg/L PBTK NA 50% Rat Human +DTXSID6023367 Css NA 0.3022 mg/L PBTK NA 95% Rat Human +DTXSID6023369 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023369 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023369 Vd NA 0.9491 L/kg 1compartment NA NA Human Human DTXSID6023369 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023369 TK.Half.Life NA 7.383 hours 1compartment NA NA Human Human -DTXSID6023369 Css NA 0.9398 mg/L 3compartmentss NA 50% Human Human -DTXSID6023369 Css NA 5.671 mg/L 3compartmentss NA 95% Human Human -DTXSID6023369 Css NA 0.6284 mg/L PBTK NA 50% Human Human -DTXSID6023369 Css NA 3.51 mg/L PBTK NA 95% Human Human -DTXSID6023369 Clint NA 4.071 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023369 Fup NA 0.1404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023369 Vd NA 0.8461 L/kg 1compartment NA NA Rat Human +DTXSID6023369 TK.Half.Life NA 5.59 hours 1compartment NA NA Human Human +DTXSID6023369 Css NA 0.7896 mg/L 3compartmentss NA 50% Human Human +DTXSID6023369 Css NA 5.487 mg/L 3compartmentss NA 95% Human Human +DTXSID6023369 Css NA 0.5155 mg/L PBTK NA 50% Human Human +DTXSID6023369 Css NA 3.358 mg/L PBTK NA 95% Human Human +DTXSID6023369 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023369 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023369 Vd NA 0.7575 L/kg 1compartment NA NA Rat Human DTXSID6023369 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023369 TK.Half.Life NA 3.197 hours 1compartment NA NA Rat Human -DTXSID6023369 Css NA 0.47 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023369 Css NA 2.19 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023369 Css NA 0.2972 mg/L PBTK NA 50% Rat Human -DTXSID6023369 Css NA 1.262 mg/L PBTK NA 95% Rat Human -DTXSID6023440 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023440 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023440 Vd NA 0.7236 L/kg 1compartment NA NA Human Human +DTXSID6023369 TK.Half.Life NA 2.528 hours 1compartment NA NA Rat Human +DTXSID6023369 Css NA 0.09637 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023369 Css NA 0.4979 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023369 Css NA 0.06152 mg/L PBTK NA 50% Rat Human +DTXSID6023369 Css NA 0.2946 mg/L PBTK NA 95% Rat Human +DTXSID60233938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60233938 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60233938 Vd NA 2.453 L/kg 1compartment NA NA Human Human +DTXSID60233938 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60233938 TK.Half.Life NA 10.11 hours 1compartment NA NA Human Human +DTXSID60233938 Css NA 0.4572 mg/L 3compartmentss NA 50% Human Human +DTXSID60233938 Css NA 2.993 mg/L 3compartmentss NA 95% Human Human +DTXSID60233938 Css NA 0.3121 mg/L PBTK NA 50% Human Human +DTXSID60233938 Css NA 1.983 mg/L PBTK NA 95% Human Human +DTXSID60233938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60233938 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60233938 Vd NA 0.5019 L/kg 1compartment NA NA Rat Human +DTXSID60233938 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID60233938 TK.Half.Life NA 9.425 hours 1compartment NA NA Rat Human +DTXSID60233938 Css NA 0.6874 mg/L 3compartmentss NA 50% Rat Human +DTXSID60233938 Css NA 5.534 mg/L 3compartmentss NA 95% Rat Human +DTXSID60233938 Css NA 0.3932 mg/L PBTK NA 50% Rat Human +DTXSID60233938 Css NA 3.119 mg/L PBTK NA 95% Rat Human +DTXSID6023440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023440 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023440 Vd NA 0.7104 L/kg 1compartment NA NA Human Human DTXSID6023440 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6023440 TK.Half.Life NA 14.28 hours 1compartment NA NA Human Human -DTXSID6023440 Css NA 2.232 mg/L 3compartmentss NA 50% Human Human -DTXSID6023440 Css NA 9.34 mg/L 3compartmentss NA 95% Human Human -DTXSID6023440 Css NA 1.619 mg/L PBTK NA 50% Human Human -DTXSID6023440 Css NA 5.891 mg/L PBTK NA 95% Human Human -DTXSID6023440 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023440 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023440 Vd NA 0.7279 L/kg 1compartment NA NA Rat Human +DTXSID6023440 TK.Half.Life NA 11.52 hours 1compartment NA NA Human Human +DTXSID6023440 Css NA 0.9716 mg/L 3compartmentss NA 50% Human Human +DTXSID6023440 Css NA 4.634 mg/L 3compartmentss NA 95% Human Human +DTXSID6023440 Css NA 0.7221 mg/L PBTK NA 50% Human Human +DTXSID6023440 Css NA 2.947 mg/L PBTK NA 95% Human Human +DTXSID6023440 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023440 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023440 Vd NA 0.722 L/kg 1compartment NA NA Rat Human DTXSID6023440 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023440 TK.Half.Life NA 4.895 hours 1compartment NA NA Rat Human -DTXSID6023440 Css NA 0.6201 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023440 Css NA 2.151 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023440 Css NA 0.4274 mg/L PBTK NA 50% Rat Human -DTXSID6023440 Css NA 1.27 mg/L PBTK NA 95% Rat Human -DTXSID6023442 Clint NA 0.8255 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023442 Fup NA 0.6357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023442 Vd NA 0.978 L/kg 1compartment NA NA Human Human +DTXSID6023440 TK.Half.Life NA 3.99 hours 1compartment NA NA Rat Human +DTXSID6023440 Css NA 0.00516 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023440 Css NA 0.02485 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023440 Css NA 0.003685 mg/L PBTK NA 50% Rat Human +DTXSID6023440 Css NA 0.01519 mg/L PBTK NA 95% Rat Human +DTXSID6023442 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023442 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023442 Vd NA 0.7537 L/kg 1compartment NA NA Human Human DTXSID6023442 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023442 TK.Half.Life NA 4.519 hours 1compartment NA NA Human Human -DTXSID6023442 Css NA 0.4786 mg/L 3compartmentss NA 50% Human Human -DTXSID6023442 Css NA 3.547 mg/L 3compartmentss NA 95% Human Human -DTXSID6023442 Css NA 0.4048 mg/L PBTK NA 50% Human Human -DTXSID6023442 Css NA 2.316 mg/L PBTK NA 95% Human Human -DTXSID6023442 Clint NA 0.8255 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023442 Fup NA 0.6357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023442 Vd NA 0.9266 L/kg 1compartment NA NA Rat Human +DTXSID6023442 TK.Half.Life NA 0.8319 hours 1compartment NA NA Human Human +DTXSID6023442 Css NA 0.04819 mg/L 3compartmentss NA 50% Human Human +DTXSID6023442 Css NA 0.3826 mg/L 3compartmentss NA 95% Human Human +DTXSID6023442 Css NA 0.03624 mg/L PBTK NA 50% Human Human +DTXSID6023442 Css NA 0.2593 mg/L PBTK NA 95% Human Human +DTXSID6023442 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023442 Fup 0.408 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023442 Vd NA 0.7115 L/kg 1compartment NA NA Rat Human DTXSID6023442 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023442 TK.Half.Life NA 1.979 hours 1compartment NA NA Rat Human -DTXSID6023442 Css NA 0.1792 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023442 Css NA 1.172 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023442 Css NA 0.1467 mg/L PBTK NA 50% Rat Human -DTXSID6023442 Css NA 0.7043 mg/L PBTK NA 95% Rat Human -DTXSID6023490 Clint NA 7.134 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023490 Fup NA 0.0834 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023490 Vd NA 3.089 L/kg 1compartment NA NA Human Human -DTXSID6023490 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID6023490 TK.Half.Life NA 42.97 hours 1compartment NA NA Human Human -DTXSID6023490 Css NA 1.688 mg/L 3compartmentss NA 50% Human Human -DTXSID6023490 Css NA 10.44 mg/L 3compartmentss NA 95% Human Human -DTXSID6023490 Css NA 1.226 mg/L PBTK NA 50% Human Human -DTXSID6023490 Css NA 7.232 mg/L PBTK NA 95% Human Human -DTXSID6023490 Clint NA 7.134 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023490 Fup NA 0.0834 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023490 Vd NA 2.41 L/kg 1compartment NA NA Rat Human -DTXSID6023490 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6023490 TK.Half.Life NA 8.553 hours 1compartment NA NA Rat Human -DTXSID6023490 Css NA 0.911 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023490 Css NA 4.179 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023490 Css NA 0.635 mg/L PBTK NA 50% Rat Human -DTXSID6023490 Css NA 2.804 mg/L PBTK NA 95% Rat Human +DTXSID6023442 TK.Half.Life NA 0.4025 hours 1compartment NA NA Rat Human +DTXSID6023442 Css NA 0.00582 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023442 Css NA 0.03798 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023442 Css NA 0.004428 mg/L PBTK NA 50% Rat Human +DTXSID6023442 Css NA 0.02518 mg/L PBTK NA 95% Rat Human +DTXSID6023446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023446 Fup 0.35 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6023446 Vd NA 3.133 L/kg 1compartment NA NA Human Human +DTXSID6023446 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID6023446 TK.Half.Life NA 47.41 hours 1compartment NA NA Human Human +DTXSID6023446 Css NA 1.716 mg/L 3compartmentss NA 50% Human Human +DTXSID6023446 Css NA 11.01 mg/L 3compartmentss NA 95% Human Human +DTXSID6023446 Css NA 1.199 mg/L PBTK NA 50% Human Human +DTXSID6023446 Css NA 7.545 mg/L PBTK NA 95% Human Human +DTXSID6023446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023446 Fup 0.35 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6023446 Vd NA 2.355 L/kg 1compartment NA NA Rat Human +DTXSID6023446 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6023446 TK.Half.Life NA 6.614 hours 1compartment NA NA Rat Human +DTXSID6023446 Css NA 0.2212 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023446 Css NA 1.146 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023446 Css NA 0.1537 mg/L PBTK NA 50% Rat Human +DTXSID6023446 Css NA 0.7695 mg/L PBTK NA 95% Rat Human +DTXSID6023448 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023448 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6023448 Vd NA 0.509 L/kg 1compartment NA NA Human Human +DTXSID6023448 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6023448 TK.Half.Life NA 1.501 hours 1compartment NA NA Human Human +DTXSID6023448 Css NA 0.2405 mg/L 3compartmentss NA 50% Human Human +DTXSID6023448 Css NA 1.47 mg/L 3compartmentss NA 95% Human Human +DTXSID6023448 Css NA 0.1653 mg/L PBTK NA 50% Human Human +DTXSID6023448 Css NA 0.9373 mg/L PBTK NA 95% Human Human +DTXSID6023448 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023448 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6023448 Vd NA 0.4725 L/kg 1compartment NA NA Rat Human +DTXSID6023448 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6023448 TK.Half.Life NA 0.8017 hours 1compartment NA NA Rat Human +DTXSID6023448 Css NA 0.01073 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023448 Css NA 0.07703 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023448 Css NA 0.007277 mg/L PBTK NA 50% Rat Human +DTXSID6023448 Css NA 0.04861 mg/L PBTK NA 95% Rat Human +DTXSID6023490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023490 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023490 Vd NA 3.06 L/kg 1compartment NA NA Human Human +DTXSID6023490 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6023490 TK.Half.Life NA 34.69 hours 1compartment NA NA Human Human +DTXSID6023490 Css NA 1.28 mg/L 3compartmentss NA 50% Human Human +DTXSID6023490 Css NA 8.721 mg/L 3compartmentss NA 95% Human Human +DTXSID6023490 Css NA 0.8926 mg/L PBTK NA 50% Human Human +DTXSID6023490 Css NA 5.781 mg/L PBTK NA 95% Human Human +DTXSID6023490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023490 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023490 Vd NA 2.297 L/kg 1compartment NA NA Rat Human +DTXSID6023490 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6023490 TK.Half.Life NA 5.369 hours 1compartment NA NA Rat Human +DTXSID6023490 Css NA 0.1652 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023490 Css NA 0.8828 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023490 Css NA 0.1144 mg/L PBTK NA 50% Rat Human +DTXSID6023490 Css NA 0.5986 mg/L PBTK NA 95% Rat Human DTXSID6023492 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023492 Fup NA 0.0727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023492 Vd NA 0.2245 L/kg 1compartment NA NA Human Human -DTXSID6023492 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6023492 TK.Half.Life NA 19.98 hours 1compartment NA NA Human Human -DTXSID6023492 Css NA 14.56 mg/L 3compartmentss NA 50% Human Human -DTXSID6023492 Css NA 64.09 mg/L 3compartmentss NA 95% Human Human -DTXSID6023492 Css NA 8.766 mg/L PBTK NA 50% Human Human -DTXSID6023492 Css NA 37.47 mg/L PBTK NA 95% Human Human +DTXSID6023492 Vd NA 0.2781 L/kg 1compartment NA NA Human Human +DTXSID6023492 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6023492 TK.Half.Life NA 24.78 hours 1compartment NA NA Human Human +DTXSID6023492 Css NA 12.28 mg/L 3compartmentss NA 50% Human Human +DTXSID6023492 Css NA 54.15 mg/L 3compartmentss NA 95% Human Human +DTXSID6023492 Css NA 7.416 mg/L PBTK NA 50% Human Human +DTXSID6023492 Css NA 31.65 mg/L PBTK NA 95% Human Human DTXSID6023492 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023492 Fup NA 0.0727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023492 Vd NA 0.2224 L/kg 1compartment NA NA Rat Human +DTXSID6023492 Vd NA 0.2708 L/kg 1compartment NA NA Rat Human DTXSID6023492 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023492 TK.Half.Life NA 6.749 hours 1compartment NA NA Rat Human -DTXSID6023492 Css NA 4.139 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023492 Css NA 15.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023492 Css NA 2.312 mg/L PBTK NA 50% Rat Human -DTXSID6023492 Css NA 8.248 mg/L PBTK NA 95% Rat Human -DTXSID6023496 Clint NA 6.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6023492 TK.Half.Life NA 8.215 hours 1compartment NA NA Rat Human +DTXSID6023492 Css NA 0.2269 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023492 Css NA 1.444 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023492 Css NA 0.1306 mg/L PBTK NA 50% Rat Human +DTXSID6023492 Css NA 0.8156 mg/L PBTK NA 95% Rat Human +DTXSID6023496 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6023496 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6023496 Vd NA 5.439 L/kg 1compartment NA NA Human Human -DTXSID6023496 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023496 TK.Half.Life NA 4.8 hours 1compartment NA NA Human Human -DTXSID6023496 Css NA 0.0456 mg/L 3compartmentss NA 50% Human Human -DTXSID6023496 Css NA 0.5101 mg/L 3compartmentss NA 95% Human Human -DTXSID6023496 Css NA 0.07138 mg/L PBTK NA 50% Human Human -DTXSID6023496 Css NA 0.4969 mg/L PBTK NA 95% Human Human -DTXSID6023496 Clint NA 6.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6023496 Vd NA 2.713 L/kg 1compartment NA NA Human Human +DTXSID6023496 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6023496 TK.Half.Life NA 20.65 hours 1compartment NA NA Human Human +DTXSID6023496 Css NA 0.6828 mg/L 3compartmentss NA 50% Human Human +DTXSID6023496 Css NA 5.159 mg/L 3compartmentss NA 95% Human Human +DTXSID6023496 Css NA 0.7677 mg/L PBTK NA 50% Human Human +DTXSID6023496 Css NA 3.73 mg/L PBTK NA 95% Human Human +DTXSID6023496 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6023496 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6023496 Vd NA 5.58 L/kg 1compartment NA NA Rat Human +DTXSID6023496 Vd NA 2.753 L/kg 1compartment NA NA Rat Human DTXSID6023496 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023496 TK.Half.Life NA 2.78 hours 1compartment NA NA Rat Human -DTXSID6023496 Css NA 0.0207 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023496 Css NA 0.2151 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023496 Css NA 0.03389 mg/L PBTK NA 50% Rat Human -DTXSID6023496 Css NA 0.1823 mg/L PBTK NA 95% Rat Human +DTXSID6023496 TK.Half.Life NA 7.141 hours 1compartment NA NA Rat Human +DTXSID6023496 Css NA 0.03862 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023496 Css NA 0.2837 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023496 Css NA 0.04531 mg/L PBTK NA 50% Rat Human +DTXSID6023496 Css NA 0.198 mg/L PBTK NA 95% Rat Human DTXSID6023498 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6023498 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6023498 Vd NA 1.942 L/kg 1compartment NA NA Human Human DTXSID6023498 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023498 TK.Half.Life NA 7.3 hours 1compartment NA NA Human Human -DTXSID6023498 Css NA 0.2426 mg/L 3compartmentss NA 50% Human Human -DTXSID6023498 Css NA 1.231 mg/L 3compartmentss NA 95% Human Human -DTXSID6023498 Css NA 0.1386 mg/L PBTK NA 50% Human Human -DTXSID6023498 Css NA 0.7018 mg/L PBTK NA 95% Human Human +DTXSID6023498 Css NA 0.4522 mg/L 3compartmentss NA 50% Human Human +DTXSID6023498 Css NA 2.263 mg/L 3compartmentss NA 95% Human Human +DTXSID6023498 Css NA 0.2474 mg/L PBTK NA 50% Human Human +DTXSID6023498 Css NA 1.243 mg/L PBTK NA 95% Human Human DTXSID6023498 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6023498 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6023498 Vd NA 1.573 L/kg 1compartment NA NA Rat Human DTXSID6023498 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023498 TK.Half.Life NA 2.493 hours 1compartment NA NA Rat Human -DTXSID6023498 Css NA 0.2307 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023498 Css NA 0.8653 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023498 Css NA 0.1232 mg/L PBTK NA 50% Rat Human -DTXSID6023498 Css NA 0.4648 mg/L PBTK NA 95% Rat Human +DTXSID6023498 Css NA 0.0291 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023498 Css NA 0.1336 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023498 Css NA 0.01641 mg/L PBTK NA 50% Rat Human +DTXSID6023498 Css NA 0.07552 mg/L PBTK NA 95% Rat Human DTXSID6023523 Clint 107 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID6023523 Fup 0.016 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6023523 Vd NA 1.811 L/kg 1compartment NA NA Human Human DTXSID6023523 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023523 TK.Half.Life NA 4.687 hours 1compartment NA NA Human Human -DTXSID6023523 Css NA 0.2607 mg/L 3compartmentss NA 50% Human Human -DTXSID6023523 Css NA 2.59 mg/L 3compartmentss NA 95% Human Human -DTXSID6023523 Css NA 0.2368 mg/L PBTK NA 50% Human Human -DTXSID6023523 Css NA 1.919 mg/L PBTK NA 95% Human Human +DTXSID6023523 Css NA 0.1784 mg/L 3compartmentss NA 50% Human Human +DTXSID6023523 Css NA 1.621 mg/L 3compartmentss NA 95% Human Human +DTXSID6023523 Css NA 0.223 mg/L PBTK NA 50% Human Human +DTXSID6023523 Css NA 2.026 mg/L PBTK NA 95% Human Human DTXSID6023523 Clint 107 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID6023523 Fup 0.016 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6023523 Vd NA 1.654 L/kg 1compartment NA NA Rat Human DTXSID6023523 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023523 TK.Half.Life NA 1.337 hours 1compartment NA NA Rat Human -DTXSID6023523 Css NA 0.1102 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023523 Css NA 0.7895 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023523 Css NA 0.08805 mg/L PBTK NA 50% Rat Human -DTXSID6023523 Css NA 0.5494 mg/L PBTK NA 95% Rat Human +DTXSID6023523 Css NA 0.0155 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023523 Css NA 0.1037 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023523 Css NA 0.02008 mg/L PBTK NA 50% Rat Human +DTXSID6023523 Css NA 0.1342 mg/L PBTK NA 95% Rat Human DTXSID6023525 Clint 14.67 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID6023525 Fup 0.282 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6023525 Vd NA 13.31 L/kg 1compartment NA NA Human Human +DTXSID6023525 Vd NA 13.53 L/kg 1compartment NA NA Human Human DTXSID6023525 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023525 TK.Half.Life NA 17.74 hours 1compartment NA NA Human Human -DTXSID6023525 Css NA 0.07735 mg/L 3compartmentss NA 50% Human Human -DTXSID6023525 Css NA 0.4662 mg/L 3compartmentss NA 95% Human Human -DTXSID6023525 Css NA 0.06262 mg/L PBTK NA 50% Human Human -DTXSID6023525 Css NA 0.3531 mg/L PBTK NA 95% Human Human +DTXSID6023525 TK.Half.Life NA 17.09 hours 1compartment NA NA Human Human +DTXSID6023525 Css NA 0.06155 mg/L 3compartmentss NA 50% Human Human +DTXSID6023525 Css NA 0.375 mg/L 3compartmentss NA 95% Human Human +DTXSID6023525 Css NA 0.05271 mg/L PBTK NA 50% Human Human +DTXSID6023525 Css NA 0.3215 mg/L PBTK NA 95% Human Human DTXSID6023525 Clint 363.8 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID6023525 Fup 0.1 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID6023525 Vd NA 6.762 L/kg 1compartment NA NA Rat Rat +DTXSID6023525 Vd NA 6.297 L/kg 1compartment NA NA Rat Rat DTXSID6023525 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID6023525 TK.Half.Life NA 2.422 hours 1compartment NA NA Rat Rat -DTXSID6023525 Css NA 0.005656 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6023525 Css NA 0.04276 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6023525 Css NA 0.004356 mg/L PBTK NA 50% Rat Rat -DTXSID6023525 Css NA 0.02858 mg/L PBTK NA 95% Rat Rat -DTXSID6023529 Clint NA 8.352 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023529 Fup NA 0.1532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023529 Vd NA 0.9098 L/kg 1compartment NA NA Human Human +DTXSID6023525 TK.Half.Life NA 2.272 hours 1compartment NA NA Rat Rat +DTXSID6023525 Css NA 0.0009968 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6023525 Css NA 0.008542 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6023525 Css NA 0.0008933 mg/L PBTK NA 50% Rat Rat +DTXSID6023525 Css NA 0.007614 mg/L PBTK NA 95% Rat Rat +DTXSID6023529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023529 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023529 Vd NA 1.788 L/kg 1compartment NA NA Human Human DTXSID6023529 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023529 TK.Half.Life NA 3.331 hours 1compartment NA NA Human Human -DTXSID6023529 Css NA 0.4322 mg/L 3compartmentss NA 50% Human Human -DTXSID6023529 Css NA 2.927 mg/L 3compartmentss NA 95% Human Human -DTXSID6023529 Css NA 0.2878 mg/L PBTK NA 50% Human Human -DTXSID6023529 Css NA 1.848 mg/L PBTK NA 95% Human Human -DTXSID6023529 Clint NA 8.352 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023529 Fup NA 0.1532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023529 Vd NA 0.745 L/kg 1compartment NA NA Rat Human +DTXSID6023529 TK.Half.Life NA 1.754 hours 1compartment NA NA Human Human +DTXSID6023529 Css NA 0.04071 mg/L 3compartmentss NA 50% Human Human +DTXSID6023529 Css NA 0.4137 mg/L 3compartmentss NA 95% Human Human +DTXSID6023529 Css NA 0.03452 mg/L PBTK NA 50% Human Human +DTXSID6023529 Css NA 0.2985 mg/L PBTK NA 95% Human Human +DTXSID6023529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023529 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023529 Vd NA 1.485 L/kg 1compartment NA NA Rat Human DTXSID6023529 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023529 TK.Half.Life NA 1.549 hours 1compartment NA NA Rat Human -DTXSID6023529 Css NA 0.2274 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023529 Css NA 1.162 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023529 Css NA 0.1439 mg/L PBTK NA 50% Rat Human -DTXSID6023529 Css NA 0.678 mg/L PBTK NA 95% Rat Human -DTXSID6023571 Clint NA 28.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023571 Fup NA 0.1069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023571 Vd NA 2.525 L/kg 1compartment NA NA Human Human +DTXSID6023529 TK.Half.Life NA 0.6743 hours 1compartment NA NA Rat Human +DTXSID6023529 Css NA 0.00492 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023529 Css NA 0.04181 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023529 Css NA 0.004264 mg/L PBTK NA 50% Rat Human +DTXSID6023529 Css NA 0.02897 mg/L PBTK NA 95% Rat Human +DTXSID6023571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023571 Fup 0.0536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023571 Vd NA 2.348 L/kg 1compartment NA NA Human Human DTXSID6023571 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023571 TK.Half.Life NA 3.666 hours 1compartment NA NA Human Human -DTXSID6023571 Css NA 0.1054 mg/L 3compartmentss NA 50% Human Human -DTXSID6023571 Css NA 0.9974 mg/L 3compartmentss NA 95% Human Human -DTXSID6023571 Css NA 0.09221 mg/L PBTK NA 50% Human Human -DTXSID6023571 Css NA 0.7287 mg/L PBTK NA 95% Human Human -DTXSID6023571 Clint NA 28.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023571 Fup NA 0.1069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023571 Vd NA 2.499 L/kg 1compartment NA NA Rat Human +DTXSID6023571 TK.Half.Life NA 5.063 hours 1compartment NA NA Human Human +DTXSID6023571 Css NA 0.173 mg/L 3compartmentss NA 50% Human Human +DTXSID6023571 Css NA 1.627 mg/L 3compartmentss NA 95% Human Human +DTXSID6023571 Css NA 0.1396 mg/L PBTK NA 50% Human Human +DTXSID6023571 Css NA 1.142 mg/L PBTK NA 95% Human Human +DTXSID6023571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023571 Fup 0.0536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023571 Vd NA 2.223 L/kg 1compartment NA NA Rat Human DTXSID6023571 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023571 TK.Half.Life NA 2.059 hours 1compartment NA NA Rat Human -DTXSID6023571 Css NA 0.05904 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023571 Css NA 0.4536 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023571 Css NA 0.04955 mg/L PBTK NA 50% Rat Human -DTXSID6023571 Css NA 0.3106 mg/L PBTK NA 95% Rat Human +DTXSID6023571 TK.Half.Life NA 2.709 hours 1compartment NA NA Rat Human +DTXSID6023571 Css NA 0.008415 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023571 Css NA 0.09321 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023571 Css NA 0.006674 mg/L PBTK NA 50% Rat Human +DTXSID6023571 Css NA 0.0611 mg/L PBTK NA 95% Rat Human DTXSID6023573 Clint 7.399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6023573 Fup 0.9 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human DTXSID6023573 Vd NA 1.629 L/kg 1compartment NA NA Human Human DTXSID6023573 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023573 TK.Half.Life NA 1.648 hours 1compartment NA NA Human Human -DTXSID6023573 Css NA 0.06524 mg/L 3compartmentss NA 50% Human Human -DTXSID6023573 Css NA 0.4202 mg/L 3compartmentss NA 95% Human Human -DTXSID6023573 Css NA 0.0583 mg/L PBTK NA 50% Human Human -DTXSID6023573 Css NA 0.3298 mg/L PBTK NA 95% Human Human +DTXSID6023573 Css NA 0.05596 mg/L 3compartmentss NA 50% Human Human +DTXSID6023573 Css NA 0.3193 mg/L 3compartmentss NA 95% Human Human +DTXSID6023573 Css NA 0.05558 mg/L PBTK NA 50% Human Human +DTXSID6023573 Css NA 0.3183 mg/L PBTK NA 95% Human Human DTXSID6023573 Clint 7.399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID6023573 Fup 0.9 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human DTXSID6023573 Vd NA 1.575 L/kg 1compartment NA NA Rat Human DTXSID6023573 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023573 TK.Half.Life NA 0.8171 hours 1compartment NA NA Rat Human -DTXSID6023573 Css NA 0.03132 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023573 Css NA 0.161 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023573 Css NA 0.0281 mg/L PBTK NA 50% Rat Human -DTXSID6023573 Css NA 0.1198 mg/L PBTK NA 95% Rat Human +DTXSID6023573 Css NA 0.00624 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023573 Css NA 0.027 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023573 Css NA 0.006466 mg/L PBTK NA 50% Rat Human +DTXSID6023573 Css NA 0.02797 mg/L PBTK NA 95% Rat Human +DTXSID6023577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023577 Fup 0.01 NA NA https://doi.org/10.1002/bdd.711 NA Human Human +DTXSID6023577 Vd NA 2.028 L/kg 1compartment NA NA Human Human +DTXSID6023577 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6023577 TK.Half.Life NA 13.31 hours 1compartment NA NA Human Human +DTXSID6023577 Css NA 0.8682 mg/L 3compartmentss NA 50% Human Human +DTXSID6023577 Css NA 7.635 mg/L 3compartmentss NA 95% Human Human +DTXSID6023577 Css NA 0.6076 mg/L PBTK NA 50% Human Human +DTXSID6023577 Css NA 5.344 mg/L PBTK NA 95% Human Human +DTXSID6023577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023577 Fup 0.01 NA NA https://doi.org/10.1002/bdd.711 NA Rat Human +DTXSID6023577 Vd NA 1.59 L/kg 1compartment NA NA Rat Human +DTXSID6023577 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6023577 TK.Half.Life NA 4.965 hours 1compartment NA NA Rat Human +DTXSID6023577 Css NA 0.1071 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023577 Css NA 0.8014 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023577 Css NA 0.07762 mg/L PBTK NA 50% Rat Human +DTXSID6023577 Css NA 0.5811 mg/L PBTK NA 95% Rat Human DTXSID6023579 Clint 9.346 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6023579 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6023579 Vd NA 0.5984 L/kg 1compartment NA NA Human Human DTXSID6023579 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023579 TK.Half.Life NA 5.263 hours 1compartment NA NA Human Human -DTXSID6023579 Css NA 0.584 mg/L 3compartmentss NA 50% Human Human -DTXSID6023579 Css NA 6.62 mg/L 3compartmentss NA 95% Human Human -DTXSID6023579 Css NA 0.5324 mg/L PBTK NA 50% Human Human -DTXSID6023579 Css NA 4.626 mg/L PBTK NA 95% Human Human +DTXSID6023579 Css NA 0.8034 mg/L 3compartmentss NA 50% Human Human +DTXSID6023579 Css NA 7.39 mg/L 3compartmentss NA 95% Human Human +DTXSID6023579 Css NA 0.7951 mg/L PBTK NA 50% Human Human +DTXSID6023579 Css NA 7.316 mg/L PBTK NA 95% Human Human DTXSID6023579 Clint 9.346 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID6023579 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6023579 Vd NA 0.5736 L/kg 1compartment NA NA Rat Human DTXSID6023579 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023579 TK.Half.Life NA 3.28 hours 1compartment NA NA Rat Human -DTXSID6023579 Css NA 0.5607 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023579 Css NA 5.007 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023579 Css NA 0.4878 mg/L PBTK NA 50% Rat Human -DTXSID6023579 Css NA 3.154 mg/L PBTK NA 95% Rat Human +DTXSID6023579 Css NA 0.03709 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023579 Css NA 0.3526 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023579 Css NA 0.03734 mg/L PBTK NA 50% Rat Human +DTXSID6023579 Css NA 0.3584 mg/L PBTK NA 95% Rat Human DTXSID6023600 Clint 2 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID6023600 Fup 0.457 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human -DTXSID6023600 Vd NA 2.921 L/kg 1compartment NA NA Human Human +DTXSID6023600 Vd NA 2.774 L/kg 1compartment NA NA Human Human DTXSID6023600 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023600 TK.Half.Life NA 9.93 hours 1compartment NA NA Human Human -DTXSID6023600 Css NA 0.2318 mg/L 3compartmentss NA 50% Human Human -DTXSID6023600 Css NA 1.702 mg/L 3compartmentss NA 95% Human Human -DTXSID6023600 Css NA 0.2726 mg/L PBTK NA 50% Human Human -DTXSID6023600 Css NA 1.36 mg/L PBTK NA 95% Human Human +DTXSID6023600 TK.Half.Life NA 9.911 hours 1compartment NA NA Human Human +DTXSID6023600 Css NA 0.2563 mg/L 3compartmentss NA 50% Human Human +DTXSID6023600 Css NA 1.776 mg/L 3compartmentss NA 95% Human Human +DTXSID6023600 Css NA 0.278 mg/L PBTK NA 50% Human Human +DTXSID6023600 Css NA 1.383 mg/L PBTK NA 95% Human Human DTXSID6023600 Clint 2 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID6023600 Fup 0.457 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human -DTXSID6023600 Vd NA 2.937 L/kg 1compartment NA NA Rat Human +DTXSID6023600 Vd NA 2.791 L/kg 1compartment NA NA Rat Human DTXSID6023600 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023600 TK.Half.Life NA 5.449 hours 1compartment NA NA Rat Human -DTXSID6023600 Css NA 0.1005 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023600 Css NA 0.6314 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023600 Css NA 0.1184 mg/L PBTK NA 50% Rat Human -DTXSID6023600 Css NA 0.4632 mg/L PBTK NA 95% Rat Human +DTXSID6023600 TK.Half.Life NA 5.291 hours 1compartment NA NA Rat Human +DTXSID6023600 Css NA 0.02357 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023600 Css NA 0.1481 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023600 Css NA 0.02666 mg/L PBTK NA 50% Rat Human +DTXSID6023600 Css NA 0.1081 mg/L PBTK NA 95% Rat Human DTXSID6023602 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023602 Fup NA 0.6033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6023602 Vd NA 0.5606 L/kg 1compartment NA NA Human Human DTXSID6023602 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023602 TK.Half.Life NA 6.012 hours 1compartment NA NA Human Human -DTXSID6023602 Css NA 1.266 mg/L 3compartmentss NA 50% Human Human -DTXSID6023602 Css NA 8.723 mg/L 3compartmentss NA 95% Human Human -DTXSID6023602 Css NA 0.9738 mg/L PBTK NA 50% Human Human -DTXSID6023602 Css NA 5.504 mg/L PBTK NA 95% Human Human +DTXSID6023602 Css NA 1.08 mg/L 3compartmentss NA 50% Human Human +DTXSID6023602 Css NA 7.245 mg/L 3compartmentss NA 95% Human Human +DTXSID6023602 Css NA 0.8306 mg/L PBTK NA 50% Human Human +DTXSID6023602 Css NA 4.566 mg/L PBTK NA 95% Human Human DTXSID6023602 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023602 Fup NA 0.6033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6023602 Vd NA 0.5851 L/kg 1compartment NA NA Rat Human DTXSID6023602 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023602 TK.Half.Life NA 2.138 hours 1compartment NA NA Rat Human -DTXSID6023602 Css NA 0.3358 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023602 Css NA 2.037 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023602 Css NA 0.2486 mg/L PBTK NA 50% Rat Human -DTXSID6023602 Css NA 1.185 mg/L PBTK NA 95% Rat Human -DTXSID6023606 Clint NA 4.354 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023606 Fup NA 0.1451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023606 Vd NA 0.4455 L/kg 1compartment NA NA Human Human +DTXSID6023602 Css NA 0.02089 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023602 Css NA 0.1712 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023602 Css NA 0.01557 mg/L PBTK NA 50% Rat Human +DTXSID6023602 Css NA 0.1052 mg/L PBTK NA 95% Rat Human +DTXSID6023604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023604 Fup 0.075 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6023604 Vd NA 2.809 L/kg 1compartment NA NA Human Human +DTXSID6023604 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6023604 TK.Half.Life NA 21.14 hours 1compartment NA NA Human Human +DTXSID6023604 Css NA 0.8303 mg/L 3compartmentss NA 50% Human Human +DTXSID6023604 Css NA 5.008 mg/L 3compartmentss NA 95% Human Human +DTXSID6023604 Css NA 0.6143 mg/L PBTK NA 50% Human Human +DTXSID6023604 Css NA 3.706 mg/L PBTK NA 95% Human Human +DTXSID6023604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023604 Fup 0.075 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6023604 Vd NA 2.092 L/kg 1compartment NA NA Rat Human +DTXSID6023604 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6023604 TK.Half.Life NA 4.393 hours 1compartment NA NA Rat Human +DTXSID6023604 Css NA 0.1032 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023604 Css NA 0.5194 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023604 Css NA 0.07909 mg/L PBTK NA 50% Rat Human +DTXSID6023604 Css NA 0.3981 mg/L PBTK NA 95% Rat Human +DTXSID6023606 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023606 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023606 Vd NA 0.6696 L/kg 1compartment NA NA Human Human DTXSID6023606 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023606 TK.Half.Life NA 2.709 hours 1compartment NA NA Human Human -DTXSID6023606 Css NA 0.8364 mg/L 3compartmentss NA 50% Human Human -DTXSID6023606 Css NA 5.32 mg/L 3compartmentss NA 95% Human Human -DTXSID6023606 Css NA 0.5317 mg/L PBTK NA 50% Human Human -DTXSID6023606 Css NA 3.192 mg/L PBTK NA 95% Human Human -DTXSID6023606 Clint NA 4.354 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023606 Fup NA 0.1451 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023606 Vd NA 0.4032 L/kg 1compartment NA NA Rat Human +DTXSID6023606 TK.Half.Life NA 1.669 hours 1compartment NA NA Human Human +DTXSID6023606 Css NA 0.2172 mg/L 3compartmentss NA 50% Human Human +DTXSID6023606 Css NA 1.381 mg/L 3compartmentss NA 95% Human Human +DTXSID6023606 Css NA 0.1539 mg/L PBTK NA 50% Human Human +DTXSID6023606 Css NA 0.9085 mg/L PBTK NA 95% Human Human +DTXSID6023606 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023606 Fup 0.311 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023606 Vd NA 0.6059 L/kg 1compartment NA NA Rat Human DTXSID6023606 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023606 TK.Half.Life NA 1.438 hours 1compartment NA NA Rat Human -DTXSID6023606 Css NA 0.4247 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023606 Css NA 2.058 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023606 Css NA 0.2546 mg/L PBTK NA 50% Rat Human -DTXSID6023606 Css NA 1.165 mg/L PBTK NA 95% Rat Human -DTXSID6023608 Clint NA 10.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023608 Fup NA 0.0961 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023608 Vd NA 0.2258 L/kg 1compartment NA NA Human Human +DTXSID6023606 TK.Half.Life NA 0.8484 hours 1compartment NA NA Rat Human +DTXSID6023606 Css NA 0.02576 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023606 Css NA 0.1171 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023606 Css NA 0.01818 mg/L PBTK NA 50% Rat Human +DTXSID6023606 Css NA 0.07372 mg/L PBTK NA 95% Rat Human +DTXSID6023608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023608 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023608 Vd NA 0.2813 L/kg 1compartment NA NA Human Human DTXSID6023608 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023608 TK.Half.Life NA 1.022 hours 1compartment NA NA Human Human -DTXSID6023608 Css NA 0.6482 mg/L 3compartmentss NA 50% Human Human -DTXSID6023608 Css NA 4.634 mg/L 3compartmentss NA 95% Human Human -DTXSID6023608 Css NA 0.3908 mg/L PBTK NA 50% Human Human -DTXSID6023608 Css NA 2.738 mg/L PBTK NA 95% Human Human -DTXSID6023608 Clint NA 10.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023608 Fup NA 0.0961 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023608 Vd NA 0.226 L/kg 1compartment NA NA Rat Human +DTXSID6023608 TK.Half.Life NA 1.034 hours 1compartment NA NA Human Human +DTXSID6023608 Css NA 0.3373 mg/L 3compartmentss NA 50% Human Human +DTXSID6023608 Css NA 1.966 mg/L 3compartmentss NA 95% Human Human +DTXSID6023608 Css NA 0.2135 mg/L PBTK NA 50% Human Human +DTXSID6023608 Css NA 1.199 mg/L PBTK NA 95% Human Human +DTXSID6023608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023608 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023608 Vd NA 0.2834 L/kg 1compartment NA NA Rat Human DTXSID6023608 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023608 TK.Half.Life NA 0.6273 hours 1compartment NA NA Rat Human -DTXSID6023608 Css NA 0.3566 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023608 Css NA 1.864 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023608 Css NA 0.2008 mg/L PBTK NA 50% Rat Human -DTXSID6023608 Css NA 1.029 mg/L PBTK NA 95% Rat Human -DTXSID6023650 Clint NA 88.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023650 Fup NA 0.5286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023650 Vd NA 0.6652 L/kg 1compartment NA NA Human Human -DTXSID6023650 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023650 TK.Half.Life NA 0.5005 hours 1compartment NA NA Human Human -DTXSID6023650 Css NA 0.01017 mg/L 3compartmentss NA 50% Human Human -DTXSID6023650 Css NA 0.09629 mg/L 3compartmentss NA 95% Human Human -DTXSID6023650 Css NA 0.007812 mg/L PBTK NA 50% Human Human -DTXSID6023650 Css NA 0.06415 mg/L PBTK NA 95% Human Human -DTXSID6023650 Clint NA 88.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023650 Fup NA 0.5286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023650 Vd NA 0.6687 L/kg 1compartment NA NA Rat Human +DTXSID6023608 TK.Half.Life NA 0.6118 hours 1compartment NA NA Rat Human +DTXSID6023608 Css NA 0.0153 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023608 Css NA 0.1005 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023608 Css NA 0.009389 mg/L PBTK NA 50% Rat Human +DTXSID6023608 Css NA 0.05915 mg/L PBTK NA 95% Rat Human +DTXSID6023650 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023650 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023650 Vd NA 0.5499 L/kg 1compartment NA NA Human Human +DTXSID6023650 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6023650 TK.Half.Life NA 9.679 hours 1compartment NA NA Human Human +DTXSID6023650 Css NA 1.692 mg/L 3compartmentss NA 50% Human Human +DTXSID6023650 Css NA 7.31 mg/L 3compartmentss NA 95% Human Human +DTXSID6023650 Css NA 1.237 mg/L PBTK NA 50% Human Human +DTXSID6023650 Css NA 4.652 mg/L PBTK NA 95% Human Human +DTXSID6023650 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023650 Fup 0.369 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023650 Vd NA 0.55 L/kg 1compartment NA NA Rat Human DTXSID6023650 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023650 TK.Half.Life NA 0.2292 hours 1compartment NA NA Rat Human -DTXSID6023650 Css NA 0.00544 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023650 Css NA 0.04601 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023650 Css NA 0.004077 mg/L PBTK NA 50% Rat Human -DTXSID6023650 Css NA 0.02929 mg/L PBTK NA 95% Rat Human +DTXSID6023650 TK.Half.Life NA 3.29 hours 1compartment NA NA Rat Human +DTXSID6023650 Css NA 0.04205 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023650 Css NA 0.2429 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023650 Css NA 0.03024 mg/L PBTK NA 50% Rat Human +DTXSID6023650 Css NA 0.1526 mg/L PBTK NA 95% Rat Human DTXSID6023652 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6023652 Fup 0.804 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6023652 Vd NA 0.5532 L/kg 1compartment NA NA Human Human DTXSID6023652 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023652 TK.Half.Life NA 4.458 hours 1compartment NA NA Human Human -DTXSID6023652 Css NA 0.1221 mg/L 3compartmentss NA 50% Human Human -DTXSID6023652 Css NA 0.613 mg/L 3compartmentss NA 95% Human Human -DTXSID6023652 Css NA 0.09252 mg/L PBTK NA 50% Human Human -DTXSID6023652 Css NA 0.4304 mg/L PBTK NA 95% Human Human +DTXSID6023652 Css NA 0.0519 mg/L 3compartmentss NA 50% Human Human +DTXSID6023652 Css NA 0.3197 mg/L 3compartmentss NA 95% Human Human +DTXSID6023652 Css NA 0.03962 mg/L PBTK NA 50% Human Human +DTXSID6023652 Css NA 0.2297 mg/L PBTK NA 95% Human Human DTXSID6023652 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6023652 Fup 0.804 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6023652 Vd NA 0.5683 L/kg 1compartment NA NA Rat Human DTXSID6023652 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023652 TK.Half.Life NA 1.559 hours 1compartment NA NA Rat Human -DTXSID6023652 Css NA 0.05679 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023652 Css NA 0.2067 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023652 Css NA 0.04264 mg/L PBTK NA 50% Rat Human -DTXSID6023652 Css NA 0.1412 mg/L PBTK NA 95% Rat Human +DTXSID6023652 Css NA 0.0004082 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023652 Css NA 0.001974 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023652 Css NA 0.0003079 mg/L PBTK NA 50% Rat Human +DTXSID6023652 Css NA 0.001387 mg/L PBTK NA 95% Rat Human DTXSID6023656 Clint 0.915 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID6023656 Fup 0.0217 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human -DTXSID6023656 Vd NA 3.13 L/kg 1compartment NA NA Human Human -DTXSID6023656 Days.Css NA 555 Days PBTK NA NA Human Human -DTXSID6023656 TK.Half.Life NA 2094 hours 1compartment NA NA Human Human -DTXSID6023656 Css NA 81.6 mg/L 3compartmentss NA 50% Human Human -DTXSID6023656 Css NA 450.2 mg/L 3compartmentss NA 95% Human Human -DTXSID6023656 Css NA 57.18 mg/L PBTK NA 50% Human Human -DTXSID6023656 Css NA 307 mg/L PBTK NA 95% Human Human +DTXSID6023656 Vd NA 3.222 L/kg 1compartment NA NA Human Human +DTXSID6023656 Days.Css NA 431 Days PBTK NA NA Human Human +DTXSID6023656 TK.Half.Life NA 1653 hours 1compartment NA NA Human Human +DTXSID6023656 Css NA 60.62 mg/L 3compartmentss NA 50% Human Human +DTXSID6023656 Css NA 325.9 mg/L 3compartmentss NA 95% Human Human +DTXSID6023656 Css NA 43.5 mg/L PBTK NA 50% Human Human +DTXSID6023656 Css NA 223.7 mg/L PBTK NA 95% Human Human DTXSID6023656 Clint 0.915 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID6023656 Fup 0.0217 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human -DTXSID6023656 Vd NA 2.333 L/kg 1compartment NA NA Rat Human -DTXSID6023656 Days.Css NA 290 Days PBTK NA NA Rat Human -DTXSID6023656 TK.Half.Life NA 273.6 hours 1compartment NA NA Rat Human -DTXSID6023656 Css NA 46.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023656 Css NA 183.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023656 Css NA 30.8 mg/L PBTK NA 50% Rat Human -DTXSID6023656 Css NA 121 mg/L PBTK NA 95% Rat Human -DTXSID6023658 Clint NA 19.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023658 Fup NA 0.085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023658 Vd NA 2.74 L/kg 1compartment NA NA Human Human +DTXSID6023656 Vd NA 2.404 L/kg 1compartment NA NA Rat Human +DTXSID6023656 Days.Css NA 225 Days PBTK NA NA Rat Human +DTXSID6023656 TK.Half.Life NA 247.2 hours 1compartment NA NA Rat Human +DTXSID6023656 Css NA 7.964 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023656 Css NA 32.07 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023656 Css NA 5.65 mg/L PBTK NA 50% Rat Human +DTXSID6023656 Css NA 21.69 mg/L PBTK NA 95% Rat Human +DTXSID6023658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023658 Fup 0.0753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023658 Vd NA 2.595 L/kg 1compartment NA NA Human Human DTXSID6023658 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023658 TK.Half.Life NA 7.211 hours 1compartment NA NA Human Human -DTXSID6023658 Css NA 0.2576 mg/L 3compartmentss NA 50% Human Human -DTXSID6023658 Css NA 2.041 mg/L 3compartmentss NA 95% Human Human -DTXSID6023658 Css NA 0.2045 mg/L PBTK NA 50% Human Human -DTXSID6023658 Css NA 1.462 mg/L PBTK NA 95% Human Human -DTXSID6023658 Clint NA 19.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023658 Fup NA 0.085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023658 Vd NA 2.427 L/kg 1compartment NA NA Rat Human +DTXSID6023658 TK.Half.Life NA 6.717 hours 1compartment NA NA Human Human +DTXSID6023658 Css NA 0.2513 mg/L 3compartmentss NA 50% Human Human +DTXSID6023658 Css NA 1.954 mg/L 3compartmentss NA 95% Human Human +DTXSID6023658 Css NA 0.1949 mg/L PBTK NA 50% Human Human +DTXSID6023658 Css NA 1.364 mg/L PBTK NA 95% Human Human +DTXSID6023658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023658 Fup 0.0753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023658 Vd NA 2.294 L/kg 1compartment NA NA Rat Human DTXSID6023658 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023658 TK.Half.Life NA 3.1 hours 1compartment NA NA Rat Human -DTXSID6023658 Css NA 0.1428 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023658 Css NA 0.9076 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023658 Css NA 0.1083 mg/L PBTK NA 50% Rat Human -DTXSID6023658 Css NA 0.6145 mg/L PBTK NA 95% Rat Human +DTXSID6023658 TK.Half.Life NA 2.947 hours 1compartment NA NA Rat Human +DTXSID6023658 Css NA 0.03197 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023658 Css NA 0.2049 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023658 Css NA 0.02467 mg/L PBTK NA 50% Rat Human +DTXSID6023658 Css NA 0.1422 mg/L PBTK NA 95% Rat Human +DTXSID60236686 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60236686 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60236686 Vd NA 0.826 L/kg 1compartment NA NA Human Human +DTXSID60236686 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60236686 TK.Half.Life NA 0.9264 hours 1compartment NA NA Human Human +DTXSID60236686 Css NA 0.04954 mg/L 3compartmentss NA 50% Human Human +DTXSID60236686 Css NA 0.3926 mg/L 3compartmentss NA 95% Human Human +DTXSID60236686 Css NA 0.03764 mg/L PBTK NA 50% Human Human +DTXSID60236686 Css NA 0.2701 mg/L PBTK NA 95% Human Human +DTXSID60236686 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60236686 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60236686 Vd NA 0.7999 L/kg 1compartment NA NA Rat Human +DTXSID60236686 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60236686 TK.Half.Life NA 0.464 hours 1compartment NA NA Rat Human +DTXSID60236686 Css NA 0.006016 mg/L 3compartmentss NA 50% Rat Human +DTXSID60236686 Css NA 0.03915 mg/L 3compartmentss NA 95% Rat Human +DTXSID60236686 Css NA 0.00461 mg/L PBTK NA 50% Rat Human +DTXSID60236686 Css NA 0.02673 mg/L PBTK NA 95% Rat Human DTXSID6023733 Clint 0.4366 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID6023733 Fup 0.214 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID6023733 Vd NA 0.3316 L/kg 1compartment NA NA Human Human DTXSID6023733 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023733 TK.Half.Life NA 5.879 hours 1compartment NA NA Human Human -DTXSID6023733 Css NA 1.911 mg/L 3compartmentss NA 50% Human Human -DTXSID6023733 Css NA 6.33 mg/L 3compartmentss NA 95% Human Human -DTXSID6023733 Css NA 1.433 mg/L PBTK NA 50% Human Human -DTXSID6023733 Css NA 4.233 mg/L PBTK NA 95% Human Human +DTXSID6023733 Css NA 1.903 mg/L 3compartmentss NA 50% Human Human +DTXSID6023733 Css NA 5.584 mg/L 3compartmentss NA 95% Human Human +DTXSID6023733 Css NA 1.406 mg/L PBTK NA 50% Human Human +DTXSID6023733 Css NA 4.131 mg/L PBTK NA 95% Human Human DTXSID6023733 Clint 4.6 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID6023733 Fup 0.37 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID6023733 Vd NA 0.3857 L/kg 1compartment NA NA Rat Rat +DTXSID6023733 Vd 0.22 0.3857 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID6023733 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID6023733 TK.Half.Life NA 0.5635 hours 1compartment NA NA Rat Rat -DTXSID6023733 Css NA 0.1165 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6023733 Css NA 0.5542 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6023733 Css NA 0.08335 mg/L PBTK NA 50% Rat Rat -DTXSID6023733 Css NA 0.3418 mg/L PBTK NA 95% Rat Rat -DTXSID6023735 Clint NA 1.787 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6023733 TK.Half.Life 0.3 0.5635 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID6023733 Css 0.083 0.02524 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID6023733 Css 0.083 0.1015 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID6023733 Css 0.083 0.01935 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID6023733 Css 0.083 0.07778 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID6023735 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6023735 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6023735 Vd NA 0.3676 L/kg 1compartment NA NA Human Human -DTXSID6023735 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6023735 TK.Half.Life NA 15.16 hours 1compartment NA NA Human Human -DTXSID6023735 Css NA 1.833 mg/L 3compartmentss NA 50% Human Human -DTXSID6023735 Css NA 12.33 mg/L 3compartmentss NA 95% Human Human -DTXSID6023735 Css NA 1.047 mg/L PBTK NA 50% Human Human -DTXSID6023735 Css NA 7.132 mg/L PBTK NA 95% Human Human -DTXSID6023735 Clint NA 1.787 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6023735 Vd NA 0.2521 L/kg 1compartment NA NA Human Human +DTXSID6023735 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6023735 TK.Half.Life NA 1.343 hours 1compartment NA NA Human Human +DTXSID6023735 Css NA 0.7628 mg/L 3compartmentss NA 50% Human Human +DTXSID6023735 Css NA 7.578 mg/L 3compartmentss NA 95% Human Human +DTXSID6023735 Css NA 0.4194 mg/L PBTK NA 50% Human Human +DTXSID6023735 Css NA 4.167 mg/L PBTK NA 95% Human Human +DTXSID6023735 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6023735 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6023735 Vd NA 0.3564 L/kg 1compartment NA NA Rat Human +DTXSID6023735 Vd NA 0.2484 L/kg 1compartment NA NA Rat Human DTXSID6023735 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023735 TK.Half.Life NA 8.086 hours 1compartment NA NA Rat Human -DTXSID6023735 Css NA 3.588 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023735 Css NA 18.84 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023735 Css NA 1.91 mg/L PBTK NA 50% Rat Human -DTXSID6023735 Css NA 10.15 mg/L PBTK NA 95% Rat Human -DTXSID6023737 Clint NA 21.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6023735 TK.Half.Life NA 0.8395 hours 1compartment NA NA Rat Human +DTXSID6023735 Css NA 0.0362 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023735 Css NA 0.3673 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023735 Css NA 0.02026 mg/L PBTK NA 50% Rat Human +DTXSID6023735 Css NA 0.2073 mg/L PBTK NA 95% Rat Human +DTXSID6023737 Clint 1 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID6023737 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6023737 Vd NA 7.695 L/kg 1compartment NA NA Human Human -DTXSID6023737 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023737 TK.Half.Life NA 3.149 hours 1compartment NA NA Human Human -DTXSID6023737 Css NA 0.009772 mg/L 3compartmentss NA 50% Human Human -DTXSID6023737 Css NA 0.144 mg/L 3compartmentss NA 95% Human Human -DTXSID6023737 Css NA 0.02061 mg/L PBTK NA 50% Human Human -DTXSID6023737 Css NA 0.1687 mg/L PBTK NA 95% Human Human -DTXSID6023737 Clint NA 21.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6023737 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6023737 TK.Half.Life NA 23.84 hours 1compartment NA NA Human Human +DTXSID6023737 Css NA 0.1332 mg/L 3compartmentss NA 50% Human Human +DTXSID6023737 Css NA 1.431 mg/L 3compartmentss NA 95% Human Human +DTXSID6023737 Css NA 0.2847 mg/L PBTK NA 50% Human Human +DTXSID6023737 Css NA 1.483 mg/L PBTK NA 95% Human Human +DTXSID6023737 Clint 1 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID6023737 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6023737 Vd NA 7.898 L/kg 1compartment NA NA Rat Human -DTXSID6023737 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023737 TK.Half.Life NA 1.706 hours 1compartment NA NA Rat Human -DTXSID6023737 Css NA 0.004691 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023737 Css NA 0.06416 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023737 Css NA 0.01046 mg/L PBTK NA 50% Rat Human -DTXSID6023737 Css NA 0.07229 mg/L PBTK NA 95% Rat Human -DTXSID6023810 Clint NA 28.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023810 Fup NA 0.5359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023810 Vd NA 3.233 L/kg 1compartment NA NA Human Human -DTXSID6023810 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023810 TK.Half.Life NA 12.05 hours 1compartment NA NA Human Human -DTXSID6023810 Css NA 0.3541 mg/L 3compartmentss NA 50% Human Human -DTXSID6023810 Css NA 2.258 mg/L 3compartmentss NA 95% Human Human -DTXSID6023810 Css NA 0.2519 mg/L PBTK NA 50% Human Human -DTXSID6023810 Css NA 1.563 mg/L PBTK NA 95% Human Human -DTXSID6023810 Clint NA 28.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023810 Fup NA 0.5359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023810 Vd NA 2.457 L/kg 1compartment NA NA Rat Human -DTXSID6023810 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023810 TK.Half.Life NA 2.07 hours 1compartment NA NA Rat Human -DTXSID6023810 Css NA 0.1982 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023810 Css NA 1.063 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023810 Css NA 0.1354 mg/L PBTK NA 50% Rat Human -DTXSID6023810 Css NA 0.6934 mg/L PBTK NA 95% Rat Human +DTXSID6023737 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6023737 TK.Half.Life NA 11.98 hours 1compartment NA NA Rat Human +DTXSID6023737 Css NA 0.01114 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023737 Css NA 0.1412 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023737 Css NA 0.02646 mg/L PBTK NA 50% Rat Human +DTXSID6023737 Css NA 0.1313 mg/L PBTK NA 95% Rat Human +DTXSID6023739 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023739 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023739 Vd NA 3.127 L/kg 1compartment NA NA Human Human +DTXSID6023739 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6023739 TK.Half.Life NA 23.14 hours 1compartment NA NA Human Human +DTXSID6023739 Css NA 0.4142 mg/L 3compartmentss NA 50% Human Human +DTXSID6023739 Css NA 2.803 mg/L 3compartmentss NA 95% Human Human +DTXSID6023739 Css NA 0.2984 mg/L PBTK NA 50% Human Human +DTXSID6023739 Css NA 1.932 mg/L PBTK NA 95% Human Human +DTXSID6023739 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023739 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023739 Vd NA 2.378 L/kg 1compartment NA NA Rat Human +DTXSID6023739 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6023739 TK.Half.Life NA 3.827 hours 1compartment NA NA Rat Human +DTXSID6023739 Css NA 0.004422 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023739 Css NA 0.02658 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023739 Css NA 0.003067 mg/L PBTK NA 50% Rat Human +DTXSID6023739 Css NA 0.0176 mg/L PBTK NA 95% Rat Human +DTXSID60237739 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60237739 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60237739 Vd NA 1.087 L/kg 1compartment NA NA Human Human +DTXSID60237739 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID60237739 TK.Half.Life NA 18.61 hours 1compartment NA NA Human Human +DTXSID60237739 Css NA 2.786 mg/L 3compartmentss NA 50% Human Human +DTXSID60237739 Css NA 23.56 mg/L 3compartmentss NA 95% Human Human +DTXSID60237739 Css NA 1.778 mg/L PBTK NA 50% Human Human +DTXSID60237739 Css NA 14.36 mg/L PBTK NA 95% Human Human +DTXSID60237739 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60237739 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60237739 Vd NA 0.9336 L/kg 1compartment NA NA Rat Human +DTXSID60237739 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID60237739 TK.Half.Life NA 9.615 hours 1compartment NA NA Rat Human +DTXSID60237739 Css NA 0.3497 mg/L 3compartmentss NA 50% Rat Human +DTXSID60237739 Css NA 2.344 mg/L 3compartmentss NA 95% Rat Human +DTXSID60237739 Css NA 0.216 mg/L PBTK NA 50% Rat Human +DTXSID60237739 Css NA 1.362 mg/L PBTK NA 95% Rat Human +DTXSID60238246 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60238246 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60238246 Vd NA 1.568 L/kg 1compartment NA NA Human Human +DTXSID60238246 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60238246 TK.Half.Life NA 6.71 hours 1compartment NA NA Human Human +DTXSID60238246 Css NA 0.4928 mg/L 3compartmentss NA 50% Human Human +DTXSID60238246 Css NA 4.444 mg/L 3compartmentss NA 95% Human Human +DTXSID60238246 Css NA 0.381 mg/L PBTK NA 50% Human Human +DTXSID60238246 Css NA 3.053 mg/L PBTK NA 95% Human Human +DTXSID60238246 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60238246 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60238246 Vd NA 1.305 L/kg 1compartment NA NA Rat Human +DTXSID60238246 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60238246 TK.Half.Life NA 3.103 hours 1compartment NA NA Rat Human +DTXSID60238246 Css NA 0.06368 mg/L 3compartmentss NA 50% Rat Human +DTXSID60238246 Css NA 0.4445 mg/L 3compartmentss NA 95% Rat Human +DTXSID60238246 Css NA 0.04829 mg/L PBTK NA 50% Rat Human +DTXSID60238246 Css NA 0.291 mg/L PBTK NA 95% Rat Human DTXSID6023862 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6023862 Fup 0.948 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6023862 Vd NA 0.5012 L/kg 1compartment NA NA Human Human DTXSID6023862 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023862 TK.Half.Life NA 3.42 hours 1compartment NA NA Human Human -DTXSID6023862 Css NA 0.8902 mg/L 3compartmentss NA 50% Human Human -DTXSID6023862 Css NA 2.432 mg/L 3compartmentss NA 95% Human Human -DTXSID6023862 Css NA 0.6767 mg/L PBTK NA 50% Human Human -DTXSID6023862 Css NA 1.681 mg/L PBTK NA 95% Human Human +DTXSID6023862 Css NA 0.8621 mg/L 3compartmentss NA 50% Human Human +DTXSID6023862 Css NA 2.354 mg/L 3compartmentss NA 95% Human Human +DTXSID6023862 Css NA 0.6527 mg/L PBTK NA 50% Human Human +DTXSID6023862 Css NA 1.647 mg/L PBTK NA 95% Human Human DTXSID6023862 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6023862 Fup 0.948 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6023862 Vd NA 0.5233 L/kg 1compartment NA NA Rat Human DTXSID6023862 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023862 TK.Half.Life NA 1.217 hours 1compartment NA NA Rat Human -DTXSID6023862 Css NA 0.2319 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023862 Css NA 0.5265 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023862 Css NA 0.171 mg/L PBTK NA 50% Rat Human -DTXSID6023862 Css NA 0.3371 mg/L PBTK NA 95% Rat Human +DTXSID6023862 Css NA 0.05202 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023862 Css NA 0.116 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023862 Css NA 0.03977 mg/L PBTK NA 50% Rat Human +DTXSID6023862 Css NA 0.07715 mg/L PBTK NA 95% Rat Human DTXSID6023864 Clint 2.319 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6023864 Fup 0.08599 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6023864 Vd NA 0.3371 L/kg 1compartment NA NA Human Human DTXSID6023864 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6023864 TK.Half.Life NA 5.432 hours 1compartment NA NA Human Human -DTXSID6023864 Css NA 2.545 mg/L 3compartmentss NA 50% Human Human -DTXSID6023864 Css NA 15.23 mg/L 3compartmentss NA 95% Human Human -DTXSID6023864 Css NA 1.608 mg/L PBTK NA 50% Human Human -DTXSID6023864 Css NA 9.1 mg/L PBTK NA 95% Human Human +DTXSID6023864 Css NA 2.167 mg/L 3compartmentss NA 50% Human Human +DTXSID6023864 Css NA 13.23 mg/L 3compartmentss NA 95% Human Human +DTXSID6023864 Css NA 1.369 mg/L PBTK NA 50% Human Human +DTXSID6023864 Css NA 7.929 mg/L PBTK NA 95% Human Human DTXSID6023864 Clint 2.319 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6023864 Fup 0.08599 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6023864 Vd NA 0.3321 L/kg 1compartment NA NA Rat Human DTXSID6023864 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6023864 TK.Half.Life NA 3.029 hours 1compartment NA NA Rat Human -DTXSID6023864 Css NA 1.208 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023864 Css NA 5.554 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023864 Css NA 0.7126 mg/L PBTK NA 50% Rat Human -DTXSID6023864 Css NA 3.09 mg/L PBTK NA 95% Rat Human +DTXSID6023864 Css NA 0.08706 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023864 Css NA 0.6254 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023864 Css NA 0.0529 mg/L PBTK NA 50% Rat Human +DTXSID6023864 Css NA 0.3628 mg/L PBTK NA 95% Rat Human DTXSID6023868 Clint 4.38 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6023868 Fup 1.37e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6023868 Vd NA 0.1629 L/kg 1compartment NA NA Human Human -DTXSID6023868 Days.Css NA 317 Days PBTK NA NA Human Human -DTXSID6023868 TK.Half.Life NA 1183 hours 1compartment NA NA Human Human -DTXSID6023868 Css NA 551.1 mg/L 3compartmentss NA 50% Human Human -DTXSID6023868 Css NA 2670 mg/L 3compartmentss NA 95% Human Human -DTXSID6023868 Css NA 319.8 mg/L PBTK NA 50% Human Human -DTXSID6023868 Css NA 1537 mg/L PBTK NA 95% Human Human +DTXSID6023868 Vd NA 0.1795 L/kg 1compartment NA NA Human Human +DTXSID6023868 Days.Css NA 293 Days PBTK NA NA Human Human +DTXSID6023868 TK.Half.Life NA 1095 hours 1compartment NA NA Human Human +DTXSID6023868 Css NA 32.9 mg/L 3compartmentss NA 50% Human Human +DTXSID6023868 Css NA 201 mg/L 3compartmentss NA 95% Human Human +DTXSID6023868 Css NA 19.19 mg/L PBTK NA 50% Human Human +DTXSID6023868 Css NA 116.3 mg/L PBTK NA 95% Human Human DTXSID6023868 Clint 4.38 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6023868 Fup 1.37e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6023868 Vd NA 0.1599 L/kg 1compartment NA NA Rat Human -DTXSID6023868 Days.Css NA 192 Days PBTK NA NA Rat Human -DTXSID6023868 TK.Half.Life NA 729.2 hours 1compartment NA NA Rat Human -DTXSID6023868 Css NA 345 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023868 Css NA 886.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023868 Css NA 186.3 mg/L PBTK NA 50% Rat Human -DTXSID6023868 Css NA 479 mg/L PBTK NA 95% Rat Human -DTXSID6023997 Clint NA 91.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023997 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6023997 Vd NA 11.11 L/kg 1compartment NA NA Human Human -DTXSID6023997 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID6023997 TK.Half.Life NA 84.15 hours 1compartment NA NA Human Human -DTXSID6023997 Css NA 0.4648 mg/L 3compartmentss NA 50% Human Human -DTXSID6023997 Css NA 2.766 mg/L 3compartmentss NA 95% Human Human -DTXSID6023997 Css NA 0.5972 mg/L PBTK NA 50% Human Human -DTXSID6023997 Css NA 3.38 mg/L PBTK NA 95% Human Human -DTXSID6023997 Clint NA 91.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023997 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6023997 Vd NA 8.79 L/kg 1compartment NA NA Rat Human -DTXSID6023997 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID6023997 TK.Half.Life NA 13.11 hours 1compartment NA NA Rat Human -DTXSID6023997 Css NA 0.2526 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023997 Css NA 1.057 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023997 Css NA 0.324 mg/L PBTK NA 50% Rat Human -DTXSID6023997 Css NA 1.378 mg/L PBTK NA 95% Rat Human +DTXSID6023868 Vd NA 0.168 L/kg 1compartment NA NA Rat Human +DTXSID6023868 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6023868 TK.Half.Life NA 653.9 hours 1compartment NA NA Rat Human +DTXSID6023868 Css NA 0.299 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023868 Css NA 1.097 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023868 Css NA 0.1619 mg/L PBTK NA 50% Rat Human +DTXSID6023868 Css NA 0.5937 mg/L PBTK NA 95% Rat Human +DTXSID60239435 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60239435 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60239435 Vd NA 1.775 L/kg 1compartment NA NA Human Human +DTXSID60239435 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60239435 TK.Half.Life NA 8.169 hours 1compartment NA NA Human Human +DTXSID60239435 Css NA 0.5918 mg/L 3compartmentss NA 50% Human Human +DTXSID60239435 Css NA 4.863 mg/L 3compartmentss NA 95% Human Human +DTXSID60239435 Css NA 0.3966 mg/L PBTK NA 50% Human Human +DTXSID60239435 Css NA 3.1 mg/L PBTK NA 95% Human Human +DTXSID60239435 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60239435 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60239435 Vd NA 1.441 L/kg 1compartment NA NA Rat Human +DTXSID60239435 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60239435 TK.Half.Life NA 3.45 hours 1compartment NA NA Rat Human +DTXSID60239435 Css NA 0.07639 mg/L 3compartmentss NA 50% Rat Human +DTXSID60239435 Css NA 0.4836 mg/L 3compartmentss NA 95% Rat Human +DTXSID60239435 Css NA 0.05024 mg/L PBTK NA 50% Rat Human +DTXSID60239435 Css NA 0.294 mg/L PBTK NA 95% Rat Human +DTXSID6023997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023997 Fup 0.00837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6023997 Vd NA 11.22 L/kg 1compartment NA NA Human Human +DTXSID6023997 Days.Css NA 71 Days PBTK NA NA Human Human +DTXSID6023997 TK.Half.Life NA 337.1 hours 1compartment NA NA Human Human +DTXSID6023997 Css NA 1.862 mg/L 3compartmentss NA 50% Human Human +DTXSID6023997 Css NA 11.5 mg/L 3compartmentss NA 95% Human Human +DTXSID6023997 Css NA 2.4 mg/L PBTK NA 50% Human Human +DTXSID6023997 Css NA 14.4 mg/L PBTK NA 95% Human Human +DTXSID6023997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023997 Fup 0.00837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6023997 Vd NA 8.875 L/kg 1compartment NA NA Rat Human +DTXSID6023997 Days.Css NA 43 Days PBTK NA NA Rat Human +DTXSID6023997 TK.Half.Life NA 47.87 hours 1compartment NA NA Rat Human +DTXSID6023997 Css NA 0.2317 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023997 Css NA 1.119 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023997 Css NA 0.3115 mg/L PBTK NA 50% Rat Human +DTXSID6023997 Css NA 1.605 mg/L PBTK NA 95% Rat Human DTXSID6023999 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6023999 Fup 0.9352 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID6023999 Vd NA 1.209 L/kg 1compartment NA NA Human Human -DTXSID6023999 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6023999 TK.Half.Life NA 8.723 hours 1compartment NA NA Human Human -DTXSID6023999 Css NA 0.847 mg/L 3compartmentss NA 50% Human Human -DTXSID6023999 Css NA 4.791 mg/L 3compartmentss NA 95% Human Human -DTXSID6023999 Css NA 0.7661 mg/L PBTK NA 50% Human Human -DTXSID6023999 Css NA 3.18 mg/L PBTK NA 95% Human Human +DTXSID6023999 Vd NA 15.68 L/kg 1compartment NA NA Human Human +DTXSID6023999 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID6023999 TK.Half.Life NA 738200 hours 1compartment NA NA Human Human +DTXSID6023999 Css NA 2046 mg/L 3compartmentss NA 50% Human Human +DTXSID6023999 Css NA 5116 mg/L 3compartmentss NA 95% Human Human +DTXSID6023999 Css NA 3496 mg/L PBTK NA 50% Human Human +DTXSID6023999 Css NA 7600 mg/L PBTK NA 95% Human Human DTXSID6023999 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6023999 Fup 0.9352 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID6023999 Vd NA 1.158 L/kg 1compartment NA NA Rat Human -DTXSID6023999 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6023999 TK.Half.Life NA 2.757 hours 1compartment NA NA Rat Human -DTXSID6023999 Css NA 0.2122 mg/L 3compartmentss NA 50% Rat Human -DTXSID6023999 Css NA 1.264 mg/L 3compartmentss NA 95% Rat Human -DTXSID6023999 Css NA 0.1891 mg/L PBTK NA 50% Rat Human -DTXSID6023999 Css NA 0.7889 mg/L PBTK NA 95% Rat Human +DTXSID6023999 Vd NA 12.59 L/kg 1compartment NA NA Rat Human +DTXSID6023999 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID6023999 TK.Half.Life NA 48170 hours 1compartment NA NA Rat Human +DTXSID6023999 Css NA 122.9 mg/L 3compartmentss NA 50% Rat Human +DTXSID6023999 Css NA 208.7 mg/L 3compartmentss NA 95% Rat Human +DTXSID6023999 Css NA 225.2 mg/L PBTK NA 50% Rat Human +DTXSID6023999 Css NA 311.1 mg/L PBTK NA 95% Rat Human DTXSID6024046 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024046 Fup 0.46 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024046 Vd NA 0.6509 L/kg 1compartment NA NA Human Human DTXSID6024046 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6024046 TK.Half.Life NA 9.316 hours 1compartment NA NA Human Human -DTXSID6024046 Css NA 1.472 mg/L 3compartmentss NA 50% Human Human -DTXSID6024046 Css NA 4.34 mg/L 3compartmentss NA 95% Human Human -DTXSID6024046 Css NA 1.135 mg/L PBTK NA 50% Human Human -DTXSID6024046 Css NA 2.978 mg/L PBTK NA 95% Human Human +DTXSID6024046 Css NA 1.418 mg/L 3compartmentss NA 50% Human Human +DTXSID6024046 Css NA 4.196 mg/L 3compartmentss NA 95% Human Human +DTXSID6024046 Css NA 1.093 mg/L PBTK NA 50% Human Human +DTXSID6024046 Css NA 2.926 mg/L PBTK NA 95% Human Human DTXSID6024046 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024046 Fup 0.46 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024046 Vd NA 0.6135 L/kg 1compartment NA NA Rat Human DTXSID6024046 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6024046 TK.Half.Life NA 2.953 hours 1compartment NA NA Rat Human -DTXSID6024046 Css NA 0.3986 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024046 Css NA 0.945 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024046 Css NA 0.2964 mg/L PBTK NA 50% Rat Human -DTXSID6024046 Css NA 0.6047 mg/L PBTK NA 95% Rat Human +DTXSID6024046 Css NA 0.0894 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024046 Css NA 0.2109 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024046 Css NA 0.06888 mg/L PBTK NA 50% Rat Human +DTXSID6024046 Css NA 0.14 mg/L PBTK NA 95% Rat Human +DTXSID6024048 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human +DTXSID6024048 Fup 0.8513 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human +DTXSID6024048 Vd NA 1.06 L/kg 1compartment NA NA Human Human +DTXSID6024048 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6024048 TK.Half.Life NA 8.279 hours 1compartment NA NA Human Human +DTXSID6024048 Css NA 0.8748 mg/L 3compartmentss NA 50% Human Human +DTXSID6024048 Css NA 5.513 mg/L 3compartmentss NA 95% Human Human +DTXSID6024048 Css NA 0.7764 mg/L PBTK NA 50% Human Human +DTXSID6024048 Css NA 3.707 mg/L PBTK NA 95% Human Human +DTXSID6024048 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human +DTXSID6024048 Fup 0.8513 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human +DTXSID6024048 Vd NA 1.027 L/kg 1compartment NA NA Rat Human +DTXSID6024048 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6024048 TK.Half.Life NA 2.677 hours 1compartment NA NA Rat Human +DTXSID6024048 Css NA 0.05142 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024048 Css NA 0.3099 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024048 Css NA 0.04598 mg/L PBTK NA 50% Rat Human +DTXSID6024048 Css NA 0.1976 mg/L PBTK NA 95% Rat Human +DTXSID60240824 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60240824 Fup 0.529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60240824 Vd NA 0.7005 L/kg 1compartment NA NA Human Human +DTXSID60240824 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60240824 TK.Half.Life NA 8.632 hours 1compartment NA NA Human Human +DTXSID60240824 Css NA 1.328 mg/L 3compartmentss NA 50% Human Human +DTXSID60240824 Css NA 7.552 mg/L 3compartmentss NA 95% Human Human +DTXSID60240824 Css NA 1.048 mg/L PBTK NA 50% Human Human +DTXSID60240824 Css NA 4.802 mg/L PBTK NA 95% Human Human +DTXSID60240824 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60240824 Fup 0.529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60240824 Vd NA 0.6952 L/kg 1compartment NA NA Rat Human +DTXSID60240824 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60240824 TK.Half.Life NA 2.903 hours 1compartment NA NA Rat Human +DTXSID60240824 Css NA 0.08275 mg/L 3compartmentss NA 50% Rat Human +DTXSID60240824 Css NA 0.4414 mg/L 3compartmentss NA 95% Rat Human +DTXSID60240824 Css NA 0.06467 mg/L PBTK NA 50% Rat Human +DTXSID60240824 Css NA 0.2702 mg/L PBTK NA 95% Rat Human DTXSID6024123 Clint 467 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024123 Fup 0.00819 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024123 Vd NA 1.785 L/kg 1compartment NA NA Human Human DTXSID6024123 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6024123 TK.Half.Life NA 2.977 hours 1compartment NA NA Human Human -DTXSID6024123 Css NA 0.09564 mg/L 3compartmentss NA 50% Human Human -DTXSID6024123 Css NA 0.6779 mg/L 3compartmentss NA 95% Human Human -DTXSID6024123 Css NA 0.06128 mg/L PBTK NA 50% Human Human -DTXSID6024123 Css NA 0.4233 mg/L PBTK NA 95% Human Human +DTXSID6024123 Css NA 0.0908 mg/L 3compartmentss NA 50% Human Human +DTXSID6024123 Css NA 0.6696 mg/L 3compartmentss NA 95% Human Human +DTXSID6024123 Css NA 0.05848 mg/L PBTK NA 50% Human Human +DTXSID6024123 Css NA 0.4156 mg/L PBTK NA 95% Human Human DTXSID6024123 Clint 467 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024123 Fup 0.00819 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024123 Vd NA 1.318 L/kg 1compartment NA NA Rat Human DTXSID6024123 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6024123 TK.Half.Life NA 1.007 hours 1compartment NA NA Rat Human -DTXSID6024123 Css NA 0.05498 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024123 Css NA 0.3328 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024123 Css NA 0.03324 mg/L PBTK NA 50% Rat Human -DTXSID6024123 Css NA 0.198 mg/L PBTK NA 95% Rat Human +DTXSID6024123 Css NA 0.01217 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024123 Css NA 0.07501 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024123 Css NA 0.007656 mg/L PBTK NA 50% Rat Human +DTXSID6024123 Css NA 0.04698 mg/L PBTK NA 95% Rat Human DTXSID6024175 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6024175 Fup 0.7306 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6024175 Vd NA 1.676 L/kg 1compartment NA NA Human Human DTXSID6024175 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID6024175 TK.Half.Life NA 18.38 hours 1compartment NA NA Human Human -DTXSID6024175 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human -DTXSID6024175 Css NA 7.007 mg/L 3compartmentss NA 95% Human Human -DTXSID6024175 Css NA 0.9877 mg/L PBTK NA 50% Human Human -DTXSID6024175 Css NA 4.68 mg/L PBTK NA 95% Human Human +DTXSID6024175 Css NA 1.052 mg/L 3compartmentss NA 50% Human Human +DTXSID6024175 Css NA 6.844 mg/L 3compartmentss NA 95% Human Human +DTXSID6024175 Css NA 0.9627 mg/L PBTK NA 50% Human Human +DTXSID6024175 Css NA 4.571 mg/L PBTK NA 95% Human Human DTXSID6024175 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6024175 Fup 0.7306 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6024175 Vd NA 1.446 L/kg 1compartment NA NA Rat Human DTXSID6024175 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6024175 TK.Half.Life NA 4.612 hours 1compartment NA NA Rat Human -DTXSID6024175 Css NA 0.2818 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024175 Css NA 1.722 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024175 Css NA 0.2514 mg/L PBTK NA 50% Rat Human -DTXSID6024175 Css NA 1.072 mg/L PBTK NA 95% Rat Human -DTXSID6024200 Clint NA 9.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6024175 Css NA 0.06338 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024175 Css NA 0.3896 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024175 Css NA 0.05858 mg/L PBTK NA 50% Rat Human +DTXSID6024175 Css NA 0.2513 mg/L PBTK NA 95% Rat Human +DTXSID6024200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6024200 Fup 0.363 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024200 Vd NA 1.457 L/kg 1compartment NA NA Human Human DTXSID6024200 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024200 TK.Half.Life NA 2.792 hours 1compartment NA NA Human Human -DTXSID6024200 Css NA 0.1348 mg/L 3compartmentss NA 50% Human Human -DTXSID6024200 Css NA 0.7526 mg/L 3compartmentss NA 95% Human Human -DTXSID6024200 Css NA 0.1066 mg/L PBTK NA 50% Human Human -DTXSID6024200 Css NA 0.56 mg/L PBTK NA 95% Human Human -DTXSID6024200 Clint NA 9.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6024200 TK.Half.Life NA 1.778 hours 1compartment NA NA Human Human +DTXSID6024200 Css NA 0.04434 mg/L 3compartmentss NA 50% Human Human +DTXSID6024200 Css NA 0.3145 mg/L 3compartmentss NA 95% Human Human +DTXSID6024200 Css NA 0.03533 mg/L PBTK NA 50% Human Human +DTXSID6024200 Css NA 0.232 mg/L PBTK NA 95% Human Human +DTXSID6024200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6024200 Fup 0.363 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024200 Vd NA 1.201 L/kg 1compartment NA NA Rat Human DTXSID6024200 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024200 TK.Half.Life NA 1.163 hours 1compartment NA NA Rat Human -DTXSID6024200 Css NA 0.06976 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024200 Css NA 0.2719 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024200 Css NA 0.0537 mg/L PBTK NA 50% Rat Human -DTXSID6024200 Css NA 0.1938 mg/L PBTK NA 95% Rat Human +DTXSID6024200 TK.Half.Life NA 0.717 hours 1compartment NA NA Rat Human +DTXSID6024200 Css NA 0.001582 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024200 Css NA 0.01188 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024200 Css NA 0.001224 mg/L PBTK NA 50% Rat Human +DTXSID6024200 Css NA 0.008669 mg/L PBTK NA 95% Rat Human DTXSID6024204 Clint 1.067 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6024204 Fup 0.4787 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6024204 Vd NA 1.386 L/kg 1compartment NA NA Human Human DTXSID6024204 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6024204 TK.Half.Life NA 8.094 hours 1compartment NA NA Human Human -DTXSID6024204 Css NA 0.5668 mg/L 3compartmentss NA 50% Human Human -DTXSID6024204 Css NA 3.156 mg/L 3compartmentss NA 95% Human Human -DTXSID6024204 Css NA 0.471 mg/L PBTK NA 50% Human Human -DTXSID6024204 Css NA 2.139 mg/L PBTK NA 95% Human Human +DTXSID6024204 Css NA 0.564 mg/L 3compartmentss NA 50% Human Human +DTXSID6024204 Css NA 2.973 mg/L 3compartmentss NA 95% Human Human +DTXSID6024204 Css NA 0.4663 mg/L PBTK NA 50% Human Human +DTXSID6024204 Css NA 2.014 mg/L PBTK NA 95% Human Human DTXSID6024204 Clint 1.067 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6024204 Fup 0.4787 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6024204 Vd NA 1.182 L/kg 1compartment NA NA Rat Human DTXSID6024204 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6024204 TK.Half.Life NA 3.06 hours 1compartment NA NA Rat Human -DTXSID6024204 Css NA 0.2291 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024204 Css NA 1.071 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024204 Css NA 0.1844 mg/L PBTK NA 50% Rat Human -DTXSID6024204 Css NA 0.6702 mg/L PBTK NA 95% Rat Human +DTXSID6024204 Css NA 0.05213 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024204 Css NA 0.2421 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024204 Css NA 0.04368 mg/L PBTK NA 50% Rat Human +DTXSID6024204 Css NA 0.1542 mg/L PBTK NA 95% Rat Human DTXSID6024206 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6024206 Fup 0.09714 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6024206 Vd NA 2.173 L/kg 1compartment NA NA Human Human DTXSID6024206 Days.Css NA 70 Days PBTK NA NA Human Human DTXSID6024206 TK.Half.Life NA 311.1 hours 1compartment NA NA Human Human -DTXSID6024206 Css NA 18.95 mg/L 3compartmentss NA 50% Human Human -DTXSID6024206 Css NA 67.24 mg/L 3compartmentss NA 95% Human Human -DTXSID6024206 Css NA 12.95 mg/L PBTK NA 50% Human Human -DTXSID6024206 Css NA 42.13 mg/L PBTK NA 95% Human Human +DTXSID6024206 Css NA 18.52 mg/L 3compartmentss NA 50% Human Human +DTXSID6024206 Css NA 64.83 mg/L 3compartmentss NA 95% Human Human +DTXSID6024206 Css NA 12.6 mg/L PBTK NA 50% Human Human +DTXSID6024206 Css NA 40.36 mg/L PBTK NA 95% Human Human DTXSID6024206 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6024206 Fup 0.09714 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6024206 Vd NA 1.642 L/kg 1compartment NA NA Rat Human DTXSID6024206 Days.Css NA 16 Days PBTK NA NA Rat Human DTXSID6024206 TK.Half.Life NA 47.48 hours 1compartment NA NA Rat Human -DTXSID6024206 Css NA 5.254 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024206 Css NA 14.94 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024206 Css NA 3.392 mg/L PBTK NA 50% Rat Human -DTXSID6024206 Css NA 8.685 mg/L PBTK NA 95% Rat Human +DTXSID6024206 Css NA 1.186 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024206 Css NA 3.439 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024206 Css NA 0.7933 mg/L PBTK NA 50% Rat Human +DTXSID6024206 Css NA 2.068 mg/L PBTK NA 95% Rat Human DTXSID6024331 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6024331 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024331 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID6024331 Vd NA 0.3579 L/kg 1compartment NA NA Human Human DTXSID6024331 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024331 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID6024331 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID6024331 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID6024331 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID6024331 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID6024331 TK.Half.Life NA 7.168 hours 1compartment NA NA Human Human +DTXSID6024331 Css NA 2.029 mg/L 3compartmentss NA 50% Human Human +DTXSID6024331 Css NA 8.56 mg/L 3compartmentss NA 95% Human Human +DTXSID6024331 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID6024331 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID6024331 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6024331 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024331 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID6024331 Vd NA 0.3709 L/kg 1compartment NA NA Rat Human DTXSID6024331 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024331 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID6024331 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024331 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024331 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID6024331 Css NA 1.313 mg/L PBTK NA 95% Rat Human +DTXSID6024331 TK.Half.Life NA 2.531 hours 1compartment NA NA Rat Human +DTXSID6024331 Css NA 0.03806 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024331 Css NA 0.2256 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024331 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID6024331 Css NA 0.1369 mg/L PBTK NA 95% Rat Human DTXSID6024337 Clint 233 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024337 Fup 1.88e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024337 Vd NA 0.1918 L/kg 1compartment NA NA Human Human DTXSID6024337 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID6024337 TK.Half.Life NA 22.04 hours 1compartment NA NA Human Human -DTXSID6024337 Css NA 7.873 mg/L 3compartmentss NA 50% Human Human -DTXSID6024337 Css NA 52.86 mg/L 3compartmentss NA 95% Human Human -DTXSID6024337 Css NA 4.608 mg/L PBTK NA 50% Human Human -DTXSID6024337 Css NA 30.3 mg/L PBTK NA 95% Human Human +DTXSID6024337 Css NA 7.766 mg/L 3compartmentss NA 50% Human Human +DTXSID6024337 Css NA 53.61 mg/L 3compartmentss NA 95% Human Human +DTXSID6024337 Css NA 4.563 mg/L PBTK NA 50% Human Human +DTXSID6024337 Css NA 30.7 mg/L PBTK NA 95% Human Human DTXSID6024337 Clint 233 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024337 Fup 1.88e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024337 Vd NA 0.1742 L/kg 1compartment NA NA Rat Human DTXSID6024337 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID6024337 TK.Half.Life NA 13.98 hours 1compartment NA NA Rat Human -DTXSID6024337 Css NA 5.626 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024337 Css NA 20.62 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024337 Css NA 3.042 mg/L PBTK NA 50% Rat Human -DTXSID6024337 Css NA 11.14 mg/L PBTK NA 95% Rat Human -DTXSID6024412 Clint NA 2.182 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024412 Fup NA 0.4754 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024412 Vd NA 1.351 L/kg 1compartment NA NA Human Human +DTXSID6024337 Css NA 1.27 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024337 Css NA 4.976 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024337 Css NA 0.7108 mg/L PBTK NA 50% Rat Human +DTXSID6024337 Css NA 2.791 mg/L PBTK NA 95% Rat Human +DTXSID6024412 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024412 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024412 Vd NA 1.042 L/kg 1compartment NA NA Human Human DTXSID6024412 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024412 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human -DTXSID6024412 Css NA 0.3515 mg/L 3compartmentss NA 50% Human Human -DTXSID6024412 Css NA 2.122 mg/L 3compartmentss NA 95% Human Human -DTXSID6024412 Css NA 0.289 mg/L PBTK NA 50% Human Human -DTXSID6024412 Css NA 1.449 mg/L PBTK NA 95% Human Human -DTXSID6024412 Clint NA 2.182 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024412 Fup NA 0.4754 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024412 Vd NA 1.156 L/kg 1compartment NA NA Rat Human +DTXSID6024412 TK.Half.Life NA 1.378 hours 1compartment NA NA Human Human +DTXSID6024412 Css NA 0.07092 mg/L 3compartmentss NA 50% Human Human +DTXSID6024412 Css NA 0.5054 mg/L 3compartmentss NA 95% Human Human +DTXSID6024412 Css NA 0.0522 mg/L PBTK NA 50% Human Human +DTXSID6024412 Css NA 0.3503 mg/L PBTK NA 95% Human Human +DTXSID6024412 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024412 Fup 0.296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024412 Vd NA 0.8873 L/kg 1compartment NA NA Rat Human DTXSID6024412 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024412 TK.Half.Life NA 2.101 hours 1compartment NA NA Rat Human -DTXSID6024412 Css NA 0.1566 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024412 Css NA 0.7593 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024412 Css NA 0.1253 mg/L PBTK NA 50% Rat Human -DTXSID6024412 Css NA 0.4779 mg/L PBTK NA 95% Rat Human -DTXSID6024414 Clint NA 1.708 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024414 Fup NA 0.4429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024414 Vd NA 1.329 L/kg 1compartment NA NA Human Human +DTXSID6024412 TK.Half.Life NA 0.6064 hours 1compartment NA NA Rat Human +DTXSID6024412 Css NA 0.008716 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024412 Css NA 0.05093 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024412 Css NA 0.00645 mg/L PBTK NA 50% Rat Human +DTXSID6024412 Css NA 0.03394 mg/L PBTK NA 95% Rat Human +DTXSID6024414 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024414 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024414 Vd NA 1.062 L/kg 1compartment NA NA Human Human DTXSID6024414 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024414 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human -DTXSID6024414 Css NA 0.454 mg/L 3compartmentss NA 50% Human Human -DTXSID6024414 Css NA 2.465 mg/L 3compartmentss NA 95% Human Human -DTXSID6024414 Css NA 0.369 mg/L PBTK NA 50% Human Human -DTXSID6024414 Css NA 1.703 mg/L PBTK NA 95% Human Human -DTXSID6024414 Clint NA 1.708 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024414 Fup NA 0.4429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024414 Vd NA 1.132 L/kg 1compartment NA NA Rat Human +DTXSID6024414 TK.Half.Life NA 1.401 hours 1compartment NA NA Human Human +DTXSID6024414 Css NA 0.06973 mg/L 3compartmentss NA 50% Human Human +DTXSID6024414 Css NA 0.5332 mg/L 3compartmentss NA 95% Human Human +DTXSID6024414 Css NA 0.05146 mg/L PBTK NA 50% Human Human +DTXSID6024414 Css NA 0.367 mg/L PBTK NA 95% Human Human +DTXSID6024414 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024414 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024414 Vd NA 0.9024 L/kg 1compartment NA NA Rat Human DTXSID6024414 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024414 TK.Half.Life NA 2.512 hours 1compartment NA NA Rat Human -DTXSID6024414 Css NA 0.1974 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024414 Css NA 0.8712 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024414 Css NA 0.1559 mg/L PBTK NA 50% Rat Human -DTXSID6024414 Css NA 0.54 mg/L PBTK NA 95% Rat Human +DTXSID6024414 TK.Half.Life NA 0.6139 hours 1compartment NA NA Rat Human +DTXSID6024414 Css NA 0.008694 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024414 Css NA 0.04929 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024414 Css NA 0.006434 mg/L PBTK NA 50% Rat Human +DTXSID6024414 Css NA 0.03294 mg/L PBTK NA 95% Rat Human DTXSID6024460 Clint 15.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID6024460 Fup 0.0171 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID6024460 Vd NA 1.309 L/kg 1compartment NA NA Human Human DTXSID6024460 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID6024460 TK.Half.Life NA 17.75 hours 1compartment NA NA Human Human -DTXSID6024460 Css NA 2.27 mg/L 3compartmentss NA 50% Human Human -DTXSID6024460 Css NA 20.52 mg/L 3compartmentss NA 95% Human Human -DTXSID6024460 Css NA 1.398 mg/L PBTK NA 50% Human Human -DTXSID6024460 Css NA 12.18 mg/L PBTK NA 95% Human Human +DTXSID6024460 Css NA 2.212 mg/L 3compartmentss NA 50% Human Human +DTXSID6024460 Css NA 20.02 mg/L 3compartmentss NA 95% Human Human +DTXSID6024460 Css NA 1.368 mg/L PBTK NA 50% Human Human +DTXSID6024460 Css NA 11.93 mg/L PBTK NA 95% Human Human DTXSID6024460 Clint 15.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID6024460 Fup 0.0171 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID6024460 Vd NA 0.9696 L/kg 1compartment NA NA Rat Human DTXSID6024460 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6024460 TK.Half.Life NA 7.206 hours 1compartment NA NA Rat Human -DTXSID6024460 Css NA 1.26 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024460 Css NA 8.679 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024460 Css NA 0.7293 mg/L PBTK NA 50% Rat Human -DTXSID6024460 Css NA 4.855 mg/L PBTK NA 95% Rat Human -DTXSID6024462 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024462 Fup NA 0.5184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024462 Vd NA 0.4092 L/kg 1compartment NA NA Human Human +DTXSID6024460 Css NA 0.2894 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024460 Css NA 2.12 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024460 Css NA 0.1731 mg/L PBTK NA 50% Rat Human +DTXSID6024460 Css NA 1.218 mg/L PBTK NA 95% Rat Human +DTXSID6024462 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024462 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024462 Vd NA 0.371 L/kg 1compartment NA NA Human Human DTXSID6024462 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024462 TK.Half.Life NA 5.108 hours 1compartment NA NA Human Human -DTXSID6024462 Css NA 1.51 mg/L 3compartmentss NA 50% Human Human -DTXSID6024462 Css NA 8.024 mg/L 3compartmentss NA 95% Human Human -DTXSID6024462 Css NA 1.088 mg/L PBTK NA 50% Human Human -DTXSID6024462 Css NA 4.922 mg/L PBTK NA 95% Human Human -DTXSID6024462 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024462 Fup NA 0.5184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024462 Vd NA 0.4348 L/kg 1compartment NA NA Rat Human +DTXSID6024462 TK.Half.Life NA 6.918 hours 1compartment NA NA Human Human +DTXSID6024462 Css NA 2.16 mg/L 3compartmentss NA 50% Human Human +DTXSID6024462 Css NA 8.711 mg/L 3compartmentss NA 95% Human Human +DTXSID6024462 Css NA 1.493 mg/L PBTK NA 50% Human Human +DTXSID6024462 Css NA 5.368 mg/L PBTK NA 95% Human Human +DTXSID6024462 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024462 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024462 Vd NA 0.3875 L/kg 1compartment NA NA Rat Human DTXSID6024462 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024462 TK.Half.Life NA 1.849 hours 1compartment NA NA Rat Human -DTXSID6024462 Css NA 0.4074 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024462 Css NA 1.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024462 Css NA 0.2793 mg/L PBTK NA 50% Rat Human -DTXSID6024462 Css NA 1.085 mg/L PBTK NA 95% Rat Human +DTXSID6024462 TK.Half.Life NA 2.462 hours 1compartment NA NA Rat Human +DTXSID6024462 Css NA 0.1395 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024462 Css NA 0.4765 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024462 Css NA 0.09394 mg/L PBTK NA 50% Rat Human +DTXSID6024462 Css NA 0.2846 mg/L PBTK NA 95% Rat Human DTXSID6024466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024466 Fup 0.766 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024466 Vd NA 0.5824 L/kg 1compartment NA NA Human Human DTXSID6024466 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6024466 TK.Half.Life NA 4.919 hours 1compartment NA NA Human Human -DTXSID6024466 Css NA 0.8609 mg/L 3compartmentss NA 50% Human Human -DTXSID6024466 Css NA 2.544 mg/L 3compartmentss NA 95% Human Human -DTXSID6024466 Css NA 0.7009 mg/L PBTK NA 50% Human Human -DTXSID6024466 Css NA 1.817 mg/L PBTK NA 95% Human Human +DTXSID6024466 Css NA 0.8309 mg/L 3compartmentss NA 50% Human Human +DTXSID6024466 Css NA 2.494 mg/L 3compartmentss NA 95% Human Human +DTXSID6024466 Css NA 0.6751 mg/L PBTK NA 50% Human Human +DTXSID6024466 Css NA 1.787 mg/L PBTK NA 95% Human Human DTXSID6024466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024466 Fup 0.766 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024466 Vd NA 0.5927 L/kg 1compartment NA NA Rat Human DTXSID6024466 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6024466 TK.Half.Life NA 1.706 hours 1compartment NA NA Rat Human -DTXSID6024466 Css NA 0.2278 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024466 Css NA 0.5615 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024466 Css NA 0.181 mg/L PBTK NA 50% Rat Human -DTXSID6024466 Css NA 0.3726 mg/L PBTK NA 95% Rat Human -DTXSID6024591 Clint NA 64.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024591 Fup NA 0.1274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024591 Vd NA 2.619 L/kg 1compartment NA NA Human Human -DTXSID6024591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024591 TK.Half.Life NA 5.089 hours 1compartment NA NA Human Human -DTXSID6024591 Css NA 0.1561 mg/L 3compartmentss NA 50% Human Human -DTXSID6024591 Css NA 1.047 mg/L 3compartmentss NA 95% Human Human -DTXSID6024591 Css NA 0.1095 mg/L PBTK NA 50% Human Human -DTXSID6024591 Css NA 0.7085 mg/L PBTK NA 95% Human Human -DTXSID6024591 Clint NA 64.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024591 Fup NA 0.1274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024591 Vd NA 1.977 L/kg 1compartment NA NA Rat Human +DTXSID6024466 Css NA 0.04924 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024466 Css NA 0.121 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024466 Css NA 0.04074 mg/L PBTK NA 50% Rat Human +DTXSID6024466 Css NA 0.08354 mg/L PBTK NA 95% Rat Human +DTXSID6024591 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024591 Fup 0.0259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024591 Vd NA 1.644 L/kg 1compartment NA NA Human Human +DTXSID6024591 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6024591 TK.Half.Life NA 12.89 hours 1compartment NA NA Human Human +DTXSID6024591 Css NA 1.16 mg/L 3compartmentss NA 50% Human Human +DTXSID6024591 Css NA 9.829 mg/L 3compartmentss NA 95% Human Human +DTXSID6024591 Css NA 0.7341 mg/L PBTK NA 50% Human Human +DTXSID6024591 Css NA 5.929 mg/L PBTK NA 95% Human Human +DTXSID6024591 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024591 Fup 0.0259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024591 Vd NA 1.223 L/kg 1compartment NA NA Rat Human DTXSID6024591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024591 TK.Half.Life NA 1.379 hours 1compartment NA NA Rat Human -DTXSID6024591 Css NA 0.08752 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024591 Css NA 0.4671 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024591 Css NA 0.05826 mg/L PBTK NA 50% Rat Human -DTXSID6024591 Css NA 0.2998 mg/L PBTK NA 95% Rat Human -DTXSID6024597 Clint NA 14.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024597 Fup NA 0.0455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024597 Vd NA 2.359 L/kg 1compartment NA NA Human Human -DTXSID6024597 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6024597 TK.Half.Life NA 23.82 hours 1compartment NA NA Human Human -DTXSID6024597 Css NA 1.41 mg/L 3compartmentss NA 50% Human Human -DTXSID6024597 Css NA 9.189 mg/L 3compartmentss NA 95% Human Human -DTXSID6024597 Css NA 0.9394 mg/L PBTK NA 50% Human Human -DTXSID6024597 Css NA 5.852 mg/L PBTK NA 95% Human Human -DTXSID6024597 Clint NA 14.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024597 Fup NA 0.0455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024597 Vd NA 1.767 L/kg 1compartment NA NA Rat Human -DTXSID6024597 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6024597 TK.Half.Life NA 6.436 hours 1compartment NA NA Rat Human -DTXSID6024597 Css NA 0.7746 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024597 Css NA 3.795 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024597 Css NA 0.4898 mg/L PBTK NA 50% Rat Human -DTXSID6024597 Css NA 2.329 mg/L PBTK NA 95% Rat Human -DTXSID6024622 Clint NA 1.546 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024622 Fup NA 0.3324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024622 Vd NA 1.339 L/kg 1compartment NA NA Human Human -DTXSID6024622 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024622 TK.Half.Life NA 8.873 hours 1compartment NA NA Human Human -DTXSID6024622 Css NA 0.6936 mg/L 3compartmentss NA 50% Human Human -DTXSID6024622 Css NA 3.245 mg/L 3compartmentss NA 95% Human Human -DTXSID6024622 Css NA 0.535 mg/L PBTK NA 50% Human Human -DTXSID6024622 Css NA 2.192 mg/L PBTK NA 95% Human Human -DTXSID6024622 Clint NA 1.546 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024622 Fup NA 0.3324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024622 Vd NA 1.109 L/kg 1compartment NA NA Rat Human -DTXSID6024622 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024622 TK.Half.Life NA 3.426 hours 1compartment NA NA Rat Human -DTXSID6024622 Css NA 0.2984 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024622 Css NA 1.095 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024622 Css NA 0.2217 mg/L PBTK NA 50% Rat Human -DTXSID6024622 Css NA 0.6785 mg/L PBTK NA 95% Rat Human -DTXSID6024624 Clint NA 17.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024624 Fup NA 0.0301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024624 Vd NA 1.599 L/kg 1compartment NA NA Human Human -DTXSID6024624 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6024624 TK.Half.Life NA 13.62 hours 1compartment NA NA Human Human -DTXSID6024624 Css NA 1.317 mg/L 3compartmentss NA 50% Human Human -DTXSID6024624 Css NA 10.88 mg/L 3compartmentss NA 95% Human Human -DTXSID6024624 Css NA 0.8376 mg/L PBTK NA 50% Human Human -DTXSID6024624 Css NA 6.657 mg/L PBTK NA 95% Human Human -DTXSID6024624 Clint NA 17.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024624 Fup NA 0.0301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024624 Vd NA 1.192 L/kg 1compartment NA NA Rat Human +DTXSID6024591 TK.Half.Life NA 4.744 hours 1compartment NA NA Rat Human +DTXSID6024591 Css NA 0.1507 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024591 Css NA 1.102 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024591 Css NA 0.09306 mg/L PBTK NA 50% Rat Human +DTXSID6024591 Css NA 0.644 mg/L PBTK NA 95% Rat Human +DTXSID6024597 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024597 Fup 0.0192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024597 Vd NA 1.477 L/kg 1compartment NA NA Human Human +DTXSID6024597 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6024597 TK.Half.Life NA 13.98 hours 1compartment NA NA Human Human +DTXSID6024597 Css NA 1.492 mg/L 3compartmentss NA 50% Human Human +DTXSID6024597 Css NA 12.85 mg/L 3compartmentss NA 95% Human Human +DTXSID6024597 Css NA 0.925 mg/L PBTK NA 50% Human Human +DTXSID6024597 Css NA 7.69 mg/L PBTK NA 95% Human Human +DTXSID6024597 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024597 Fup 0.0192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024597 Vd NA 1.095 L/kg 1compartment NA NA Rat Human +DTXSID6024597 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6024597 TK.Half.Life NA 5.419 hours 1compartment NA NA Rat Human +DTXSID6024597 Css NA 0.1904 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024597 Css NA 1.414 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024597 Css NA 0.1155 mg/L PBTK NA 50% Rat Human +DTXSID6024597 Css NA 0.8224 mg/L PBTK NA 95% Rat Human +DTXSID6024624 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024624 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024624 Vd NA 1.693 L/kg 1compartment NA NA Human Human +DTXSID6024624 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6024624 TK.Half.Life NA 8.59 hours 1compartment NA NA Human Human +DTXSID6024624 Css NA 0.678 mg/L 3compartmentss NA 50% Human Human +DTXSID6024624 Css NA 5.178 mg/L 3compartmentss NA 95% Human Human +DTXSID6024624 Css NA 0.4353 mg/L PBTK NA 50% Human Human +DTXSID6024624 Css NA 3.213 mg/L PBTK NA 95% Human Human +DTXSID6024624 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024624 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024624 Vd NA 1.27 L/kg 1compartment NA NA Rat Human DTXSID6024624 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024624 TK.Half.Life NA 5.085 hours 1compartment NA NA Rat Human -DTXSID6024624 Css NA 0.7437 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024624 Css NA 4.877 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024624 Css NA 0.4418 mg/L PBTK NA 50% Rat Human -DTXSID6024624 Css NA 2.742 mg/L PBTK NA 95% Rat Human +DTXSID6024624 TK.Half.Life NA 3.127 hours 1compartment NA NA Rat Human +DTXSID6024624 Css NA 0.0883 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024624 Css NA 0.546 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024624 Css NA 0.05566 mg/L PBTK NA 50% Rat Human +DTXSID6024624 Css NA 0.3306 mg/L PBTK NA 95% Rat Human DTXSID6024628 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6024628 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024628 Vd NA 0.5002 L/kg 1compartment NA NA Human Human +DTXSID6024628 Vd NA 0.467 L/kg 1compartment NA NA Human Human DTXSID6024628 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024628 TK.Half.Life NA 3.237 hours 1compartment NA NA Human Human -DTXSID6024628 Css NA 0.9273 mg/L 3compartmentss NA 50% Human Human -DTXSID6024628 Css NA 5.712 mg/L 3compartmentss NA 95% Human Human -DTXSID6024628 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID6024628 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID6024628 TK.Half.Life NA 3.023 hours 1compartment NA NA Human Human +DTXSID6024628 Css NA 0.7946 mg/L 3compartmentss NA 50% Human Human +DTXSID6024628 Css NA 5.235 mg/L 3compartmentss NA 95% Human Human +DTXSID6024628 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID6024628 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID6024628 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6024628 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024628 Vd NA 0.525 L/kg 1compartment NA NA Rat Human +DTXSID6024628 Vd NA 0.4967 L/kg 1compartment NA NA Rat Human DTXSID6024628 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024628 TK.Half.Life NA 1.157 hours 1compartment NA NA Rat Human -DTXSID6024628 Css NA 0.2355 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024628 Css NA 1.377 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024628 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID6024628 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID6024670 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024670 Fup NA 0.8665 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024670 Vd NA 0.7276 L/kg 1compartment NA NA Human Human +DTXSID6024628 TK.Half.Life NA 1.095 hours 1compartment NA NA Rat Human +DTXSID6024628 Css NA 0.0147 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024628 Css NA 0.1057 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024628 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID6024628 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID6024670 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024670 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024670 Vd NA 0.5866 L/kg 1compartment NA NA Human Human DTXSID6024670 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024670 TK.Half.Life NA 5.432 hours 1compartment NA NA Human Human -DTXSID6024670 Css NA 0.9372 mg/L 3compartmentss NA 50% Human Human -DTXSID6024670 Css NA 5.438 mg/L 3compartmentss NA 95% Human Human -DTXSID6024670 Css NA 0.7812 mg/L PBTK NA 50% Human Human -DTXSID6024670 Css NA 3.528 mg/L PBTK NA 95% Human Human -DTXSID6024670 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024670 Fup NA 0.8665 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024670 Vd NA 0.7586 L/kg 1compartment NA NA Rat Human +DTXSID6024670 TK.Half.Life NA 6.424 hours 1compartment NA NA Human Human +DTXSID6024670 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human +DTXSID6024670 Css NA 7.444 mg/L 3compartmentss NA 95% Human Human +DTXSID6024670 Css NA 0.8474 mg/L PBTK NA 50% Human Human +DTXSID6024670 Css NA 4.627 mg/L PBTK NA 95% Human Human +DTXSID6024670 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024670 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024670 Vd NA 0.6091 L/kg 1compartment NA NA Rat Human DTXSID6024670 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024670 TK.Half.Life NA 1.93 hours 1compartment NA NA Rat Human -DTXSID6024670 Css NA 0.2418 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024670 Css NA 1.441 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024670 Css NA 0.1948 mg/L PBTK NA 50% Rat Human -DTXSID6024670 Css NA 0.8647 mg/L PBTK NA 95% Rat Human -DTXSID6024674 Clint NA 90.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024674 Fup NA 0.4077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024674 Vd NA 1.252 L/kg 1compartment NA NA Human Human +DTXSID6024670 TK.Half.Life NA 2.273 hours 1compartment NA NA Rat Human +DTXSID6024670 Css NA 0.0206 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024670 Css NA 0.1809 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024670 Css NA 0.0155 mg/L PBTK NA 50% Rat Human +DTXSID6024670 Css NA 0.1105 mg/L PBTK NA 95% Rat Human +DTXSID6024674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024674 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024674 Vd NA 1.249 L/kg 1compartment NA NA Human Human DTXSID6024674 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024674 TK.Half.Life NA 0.9825 hours 1compartment NA NA Human Human -DTXSID6024674 Css NA 0.01298 mg/L 3compartmentss NA 50% Human Human -DTXSID6024674 Css NA 0.1022 mg/L 3compartmentss NA 95% Human Human -DTXSID6024674 Css NA 0.01021 mg/L PBTK NA 50% Human Human -DTXSID6024674 Css NA 0.07281 mg/L PBTK NA 95% Human Human -DTXSID6024674 Clint NA 90.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024674 Fup NA 0.4077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024674 Vd NA 1.068 L/kg 1compartment NA NA Rat Human +DTXSID6024674 TK.Half.Life NA 1.394 hours 1compartment NA NA Human Human +DTXSID6024674 Css NA 0.0493 mg/L 3compartmentss NA 50% Human Human +DTXSID6024674 Css NA 0.3912 mg/L 3compartmentss NA 95% Human Human +DTXSID6024674 Css NA 0.03902 mg/L PBTK NA 50% Human Human +DTXSID6024674 Css NA 0.2786 mg/L PBTK NA 95% Human Human +DTXSID6024674 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024674 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024674 Vd NA 1.066 L/kg 1compartment NA NA Rat Human DTXSID6024674 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024674 TK.Half.Life NA 0.3823 hours 1compartment NA NA Rat Human -DTXSID6024674 Css NA 0.006976 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024674 Css NA 0.04905 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024674 Css NA 0.005342 mg/L PBTK NA 50% Rat Human -DTXSID6024674 Css NA 0.03228 mg/L PBTK NA 95% Rat Human -DTXSID6024701 Clint NA 225.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024701 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024701 Vd NA 3.026 L/kg 1compartment NA NA Human Human -DTXSID6024701 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024701 TK.Half.Life NA 10.8 hours 1compartment NA NA Human Human -DTXSID6024701 Css NA 0.3576 mg/L 3compartmentss NA 50% Human Human -DTXSID6024701 Css NA 2.22 mg/L 3compartmentss NA 95% Human Human -DTXSID6024701 Css NA 0.2456 mg/L PBTK NA 50% Human Human -DTXSID6024701 Css NA 1.479 mg/L PBTK NA 95% Human Human -DTXSID6024701 Clint NA 225.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024701 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024701 Vd NA 2.263 L/kg 1compartment NA NA Rat Human -DTXSID6024701 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024701 TK.Half.Life NA 2.036 hours 1compartment NA NA Rat Human -DTXSID6024701 Css NA 0.2019 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024701 Css NA 0.971 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024701 Css NA 0.1319 mg/L PBTK NA 50% Rat Human -DTXSID6024701 Css NA 0.6177 mg/L PBTK NA 95% Rat Human -DTXSID6024832 Clint NA 3.575 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024832 Fup NA 0.0272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024832 Vd NA 0.2887 L/kg 1compartment NA NA Human Human -DTXSID6024832 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6024832 TK.Half.Life NA 9.867 hours 1compartment NA NA Human Human -DTXSID6024832 Css NA 6.236 mg/L 3compartmentss NA 50% Human Human -DTXSID6024832 Css NA 47.92 mg/L 3compartmentss NA 95% Human Human -DTXSID6024832 Css NA 3.708 mg/L PBTK NA 50% Human Human -DTXSID6024832 Css NA 27.87 mg/L PBTK NA 95% Human Human -DTXSID6024832 Clint NA 3.575 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024832 Fup NA 0.0272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024832 Vd NA 0.2531 L/kg 1compartment NA NA Rat Human +DTXSID6024674 TK.Half.Life NA 0.5924 hours 1compartment NA NA Rat Human +DTXSID6024674 Css NA 0.00612 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024674 Css NA 0.0384 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024674 Css NA 0.004865 mg/L PBTK NA 50% Rat Human +DTXSID6024674 Css NA 0.02656 mg/L PBTK NA 95% Rat Human +DTXSID6024832 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024832 Fup 0.0503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024832 Vd NA 0.4752 L/kg 1compartment NA NA Human Human +DTXSID6024832 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6024832 TK.Half.Life NA 5.599 hours 1compartment NA NA Human Human +DTXSID6024832 Css NA 1.91 mg/L 3compartmentss NA 50% Human Human +DTXSID6024832 Css NA 13.51 mg/L 3compartmentss NA 95% Human Human +DTXSID6024832 Css NA 1.176 mg/L PBTK NA 50% Human Human +DTXSID6024832 Css NA 8.126 mg/L PBTK NA 95% Human Human +DTXSID6024832 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024832 Fup 0.0503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024832 Vd NA 0.3915 L/kg 1compartment NA NA Rat Human DTXSID6024832 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024832 TK.Half.Life NA 5.212 hours 1compartment NA NA Rat Human -DTXSID6024832 Css NA 3.139 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024832 Css NA 19.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024832 Css NA 1.743 mg/L PBTK NA 50% Rat Human -DTXSID6024832 Css NA 10.53 mg/L PBTK NA 95% Rat Human -DTXSID6024838 Clint NA 193.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024838 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024838 Vd NA 2.2 L/kg 1compartment NA NA Human Human -DTXSID6024838 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024838 TK.Half.Life NA 6.849 hours 1compartment NA NA Human Human -DTXSID6024838 Css NA 0.3674 mg/L 3compartmentss NA 50% Human Human -DTXSID6024838 Css NA 2.918 mg/L 3compartmentss NA 95% Human Human -DTXSID6024838 Css NA 0.2368 mg/L PBTK NA 50% Human Human -DTXSID6024838 Css NA 1.803 mg/L PBTK NA 95% Human Human -DTXSID6024838 Clint NA 193.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024838 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024838 Vd NA 1.632 L/kg 1compartment NA NA Rat Human -DTXSID6024838 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024838 TK.Half.Life NA 2.061 hours 1compartment NA NA Rat Human -DTXSID6024838 Css NA 0.2061 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024838 Css NA 1.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024838 Css NA 0.1252 mg/L PBTK NA 50% Rat Human -DTXSID6024838 Css NA 0.8502 mg/L PBTK NA 95% Rat Human +DTXSID6024832 TK.Half.Life NA 2.835 hours 1compartment NA NA Rat Human +DTXSID6024832 Css NA 0.2364 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024832 Css NA 1.26 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024832 Css NA 0.1403 mg/L PBTK NA 50% Rat Human +DTXSID6024832 Css NA 0.7231 mg/L PBTK NA 95% Rat Human +DTXSID6024834 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024834 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024834 Vd NA 1.033 L/kg 1compartment NA NA Human Human +DTXSID6024834 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6024834 TK.Half.Life NA 1.692 hours 1compartment NA NA Human Human +DTXSID6024834 Css NA 0.1064 mg/L 3compartmentss NA 50% Human Human +DTXSID6024834 Css NA 0.7411 mg/L 3compartmentss NA 95% Human Human +DTXSID6024834 Css NA 0.07484 mg/L PBTK NA 50% Human Human +DTXSID6024834 Css NA 0.4968 mg/L PBTK NA 95% Human Human +DTXSID6024834 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024834 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024834 Vd NA 0.852 L/kg 1compartment NA NA Rat Human +DTXSID6024834 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6024834 TK.Half.Life NA 0.7393 hours 1compartment NA NA Rat Human +DTXSID6024834 Css NA 0.0136 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024834 Css NA 0.07067 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024834 Css NA 0.00946 mg/L PBTK NA 50% Rat Human +DTXSID6024834 Css NA 0.04659 mg/L PBTK NA 95% Rat Human +DTXSID6024838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024838 Fup 0.0179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024838 Vd NA 2.441 L/kg 1compartment NA NA Human Human +DTXSID6024838 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6024838 TK.Half.Life NA 31.29 hours 1compartment NA NA Human Human +DTXSID6024838 Css NA 1.803 mg/L 3compartmentss NA 50% Human Human +DTXSID6024838 Css NA 13.48 mg/L 3compartmentss NA 95% Human Human +DTXSID6024838 Css NA 1.191 mg/L PBTK NA 50% Human Human +DTXSID6024838 Css NA 8.524 mg/L PBTK NA 95% Human Human +DTXSID6024838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024838 Fup 0.0179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024838 Vd NA 1.819 L/kg 1compartment NA NA Rat Human +DTXSID6024838 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6024838 TK.Half.Life NA 8.015 hours 1compartment NA NA Rat Human +DTXSID6024838 Css NA 0.2334 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024838 Css NA 1.427 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024838 Css NA 0.151 mg/L PBTK NA 50% Rat Human +DTXSID6024838 Css NA 0.8882 mg/L PBTK NA 95% Rat Human DTXSID6024882 Clint 1.74 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID6024882 Fup 0.629 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID6024882 Vd NA 0.7443 L/kg 1compartment NA NA Human Human DTXSID6024882 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6024882 TK.Half.Life NA 2.258 hours 1compartment NA NA Human Human -DTXSID6024882 Css NA 0.3213 mg/L 3compartmentss NA 50% Human Human -DTXSID6024882 Css NA 2.453 mg/L 3compartmentss NA 95% Human Human -DTXSID6024882 Css NA 0.256 mg/L PBTK NA 50% Human Human -DTXSID6024882 Css NA 1.547 mg/L PBTK NA 95% Human Human +DTXSID6024882 Css NA 0.3102 mg/L 3compartmentss NA 50% Human Human +DTXSID6024882 Css NA 2.329 mg/L 3compartmentss NA 95% Human Human +DTXSID6024882 Css NA 0.2446 mg/L PBTK NA 50% Human Human +DTXSID6024882 Css NA 1.507 mg/L PBTK NA 95% Human Human DTXSID6024882 Clint 1.74 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID6024882 Fup 0.629 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID6024882 Vd NA 0.7308 L/kg 1compartment NA NA Rat Human DTXSID6024882 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6024882 TK.Half.Life NA 1.14 hours 1compartment NA NA Rat Human -DTXSID6024882 Css NA 0.1349 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024882 Css NA 0.9121 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024882 Css NA 0.1036 mg/L PBTK NA 50% Rat Human -DTXSID6024882 Css NA 0.5416 mg/L PBTK NA 95% Rat Human +DTXSID6024882 Css NA 0.0298 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024882 Css NA 0.1996 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024882 Css NA 0.02397 mg/L PBTK NA 50% Rat Human +DTXSID6024882 Css NA 0.1228 mg/L PBTK NA 95% Rat Human DTXSID6024888 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6024888 Fup 0.772 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6024888 Vd NA 0.8211 L/kg 1compartment NA NA Human Human +DTXSID6024888 Vd NA 1.018 L/kg 1compartment NA NA Human Human DTXSID6024888 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6024888 TK.Half.Life NA 6.981 hours 1compartment NA NA Human Human -DTXSID6024888 Css NA 0.8774 mg/L 3compartmentss NA 50% Human Human -DTXSID6024888 Css NA 2.626 mg/L 3compartmentss NA 95% Human Human -DTXSID6024888 Css NA 0.74 mg/L PBTK NA 50% Human Human -DTXSID6024888 Css NA 1.937 mg/L PBTK NA 95% Human Human +DTXSID6024888 TK.Half.Life NA 8.906 hours 1compartment NA NA Human Human +DTXSID6024888 Css NA 0.841 mg/L 3compartmentss NA 50% Human Human +DTXSID6024888 Css NA 2.519 mg/L 3compartmentss NA 95% Human Human +DTXSID6024888 Css NA 0.7332 mg/L PBTK NA 50% Human Human +DTXSID6024888 Css NA 1.879 mg/L PBTK NA 95% Human Human DTXSID6024888 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6024888 Fup 0.772 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6024888 Vd NA 0.8048 L/kg 1compartment NA NA Rat Human +DTXSID6024888 Vd NA 0.9529 L/kg 1compartment NA NA Rat Human DTXSID6024888 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024888 TK.Half.Life NA 2.306 hours 1compartment NA NA Rat Human -DTXSID6024888 Css NA 0.2308 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024888 Css NA 0.5768 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024888 Css NA 0.19 mg/L PBTK NA 50% Rat Human -DTXSID6024888 Css NA 0.3907 mg/L PBTK NA 95% Rat Human +DTXSID6024888 TK.Half.Life NA 2.749 hours 1compartment NA NA Rat Human +DTXSID6024888 Css NA 0.05047 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024888 Css NA 0.1283 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024888 Css NA 0.04477 mg/L PBTK NA 50% Rat Human +DTXSID6024888 Css NA 0.09234 mg/L PBTK NA 95% Rat Human DTXSID6024917 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6024917 Fup NA 0.9258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024917 Vd NA 1.377 L/kg 1compartment NA NA Human Human -DTXSID6024917 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6024917 TK.Half.Life NA 10.44 hours 1compartment NA NA Human Human -DTXSID6024917 Css NA 0.8075 mg/L 3compartmentss NA 50% Human Human -DTXSID6024917 Css NA 3.076 mg/L 3compartmentss NA 95% Human Human -DTXSID6024917 Css NA 0.7507 mg/L PBTK NA 50% Human Human -DTXSID6024917 Css NA 2.303 mg/L PBTK NA 95% Human Human +DTXSID6024917 Vd NA 0.8706 L/kg 1compartment NA NA Human Human +DTXSID6024917 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6024917 TK.Half.Life NA 6.112 hours 1compartment NA NA Human Human +DTXSID6024917 Css NA 0.7204 mg/L 3compartmentss NA 50% Human Human +DTXSID6024917 Css NA 2.77 mg/L 3compartmentss NA 95% Human Human +DTXSID6024917 Css NA 0.62 mg/L PBTK NA 50% Human Human +DTXSID6024917 Css NA 1.974 mg/L PBTK NA 95% Human Human DTXSID6024917 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6024917 Fup NA 0.9258 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024917 Vd NA 1.275 L/kg 1compartment NA NA Rat Human +DTXSID6024917 Vd NA 0.8875 L/kg 1compartment NA NA Rat Human DTXSID6024917 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6024917 TK.Half.Life NA 3.097 hours 1compartment NA NA Rat Human -DTXSID6024917 Css NA 0.2026 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024917 Css NA 0.7714 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024917 Css NA 0.1871 mg/L PBTK NA 50% Rat Human -DTXSID6024917 Css NA 0.5226 mg/L PBTK NA 95% Rat Human -DTXSID6024961 Clint NA 895.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024961 Fup NA 0.0034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024961 Vd NA 65970 L/kg 1compartment NA NA Human Human -DTXSID6024961 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID6024961 TK.Half.Life NA 48510 hours 1compartment NA NA Human Human -DTXSID6024961 Css NA 4.702e-06 mg/L 3compartmentss NA 50% Human Human -DTXSID6024961 Css NA 2.888e-05 mg/L 3compartmentss NA 95% Human Human -DTXSID6024961 Css NA 0.06124 mg/L PBTK NA 50% Human Human -DTXSID6024961 Css NA 0.3528 mg/L PBTK NA 95% Human Human -DTXSID6024961 Clint NA 895.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024961 Fup NA 0.0034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024961 Vd NA 62660 L/kg 1compartment NA NA Rat Human -DTXSID6024961 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID6024961 TK.Half.Life NA 8668 hours 1compartment NA NA Rat Human -DTXSID6024961 Css NA 2.414e-06 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024961 Css NA 1e-05 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024961 Css NA 0.03329 mg/L PBTK NA 50% Rat Human -DTXSID6024961 Css NA 0.1381 mg/L PBTK NA 95% Rat Human -DTXSID6024967 Clint NA 1.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024967 Fup NA 0.1686 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6024967 Vd NA 1.915 L/kg 1compartment NA NA Human Human -DTXSID6024967 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID6024967 TK.Half.Life NA 42.06 hours 1compartment NA NA Human Human -DTXSID6024967 Css NA 2.541 mg/L 3compartmentss NA 50% Human Human -DTXSID6024967 Css NA 9.492 mg/L 3compartmentss NA 95% Human Human -DTXSID6024967 Css NA 1.82 mg/L PBTK NA 50% Human Human -DTXSID6024967 Css NA 6.259 mg/L PBTK NA 95% Human Human -DTXSID6024967 Clint NA 1.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024967 Fup NA 0.1686 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6024967 Vd NA 1.473 L/kg 1compartment NA NA Rat Human -DTXSID6024967 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6024967 TK.Half.Life NA 11.5 hours 1compartment NA NA Rat Human -DTXSID6024967 Css NA 1.067 mg/L 3compartmentss NA 50% Rat Human -DTXSID6024967 Css NA 2.984 mg/L 3compartmentss NA 95% Rat Human -DTXSID6024967 Css NA 0.7283 mg/L PBTK NA 50% Rat Human -DTXSID6024967 Css NA 1.81 mg/L PBTK NA 95% Rat Human +DTXSID6024917 TK.Half.Life NA 2.116 hours 1compartment NA NA Rat Human +DTXSID6024917 Css NA 0.01316 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024917 Css NA 0.07132 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024917 Css NA 0.0109 mg/L PBTK NA 50% Rat Human +DTXSID6024917 Css NA 0.05223 mg/L PBTK NA 95% Rat Human +DTXSID6024967 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024967 Fup 0.087 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6024967 Vd NA 1.451 L/kg 1compartment NA NA Human Human +DTXSID6024967 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6024967 TK.Half.Life NA 4.507 hours 1compartment NA NA Human Human +DTXSID6024967 Css NA 0.3524 mg/L 3compartmentss NA 50% Human Human +DTXSID6024967 Css NA 2.621 mg/L 3compartmentss NA 95% Human Human +DTXSID6024967 Css NA 0.2318 mg/L PBTK NA 50% Human Human +DTXSID6024967 Css NA 1.641 mg/L PBTK NA 95% Human Human +DTXSID6024967 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024967 Fup 0.087 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6024967 Vd NA 1.107 L/kg 1compartment NA NA Rat Human +DTXSID6024967 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6024967 TK.Half.Life NA 1.767 hours 1compartment NA NA Rat Human +DTXSID6024967 Css NA 0.04584 mg/L 3compartmentss NA 50% Rat Human +DTXSID6024967 Css NA 0.2724 mg/L 3compartmentss NA 95% Rat Human +DTXSID6024967 Css NA 0.02945 mg/L PBTK NA 50% Rat Human +DTXSID6024967 Css NA 0.1665 mg/L PBTK NA 95% Rat Human DTXSID6025010 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6025010 Fup NA 0.782 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025010 Vd NA 1.059 L/kg 1compartment NA NA Human Human +DTXSID6025010 Vd NA 0.9189 L/kg 1compartment NA NA Human Human DTXSID6025010 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025010 TK.Half.Life NA 9.056 hours 1compartment NA NA Human Human -DTXSID6025010 Css NA 0.948 mg/L 3compartmentss NA 50% Human Human -DTXSID6025010 Css NA 6.115 mg/L 3compartmentss NA 95% Human Human -DTXSID6025010 Css NA 0.8332 mg/L PBTK NA 50% Human Human -DTXSID6025010 Css NA 4.041 mg/L PBTK NA 95% Human Human +DTXSID6025010 TK.Half.Life NA 7.714 hours 1compartment NA NA Human Human +DTXSID6025010 Css NA 0.8294 mg/L 3compartmentss NA 50% Human Human +DTXSID6025010 Css NA 5.065 mg/L 3compartmentss NA 95% Human Human +DTXSID6025010 Css NA 0.71 mg/L PBTK NA 50% Human Human +DTXSID6025010 Css NA 3.34 mg/L PBTK NA 95% Human Human DTXSID6025010 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6025010 Fup NA 0.782 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025010 Vd NA 1.015 L/kg 1compartment NA NA Rat Human +DTXSID6025010 Vd NA 0.9074 L/kg 1compartment NA NA Rat Human DTXSID6025010 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025010 TK.Half.Life NA 2.885 hours 1compartment NA NA Rat Human -DTXSID6025010 Css NA 0.2432 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025010 Css NA 1.553 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025010 Css NA 0.2081 mg/L PBTK NA 50% Rat Human -DTXSID6025010 Css NA 0.9467 mg/L PBTK NA 95% Rat Human -DTXSID6025018 Clint NA 15.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025018 Fup NA 0.2369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025018 Vd NA 3.057 L/kg 1compartment NA NA Human Human +DTXSID6025010 TK.Half.Life NA 2.567 hours 1compartment NA NA Rat Human +DTXSID6025010 Css NA 0.0154 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025010 Css NA 0.1235 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025010 Css NA 0.01278 mg/L PBTK NA 50% Rat Human +DTXSID6025010 Css NA 0.0809 mg/L PBTK NA 95% Rat Human +DTXSID6025018 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025018 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025018 Vd NA 2.791 L/kg 1compartment NA NA Human Human DTXSID6025018 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025018 TK.Half.Life NA 3.11 hours 1compartment NA NA Human Human -DTXSID6025018 Css NA 0.04314 mg/L 3compartmentss NA 50% Human Human -DTXSID6025018 Css NA 0.3776 mg/L 3compartmentss NA 95% Human Human -DTXSID6025018 Css NA 0.05318 mg/L PBTK NA 50% Human Human -DTXSID6025018 Css NA 0.3567 mg/L PBTK NA 95% Human Human -DTXSID6025018 Clint NA 15.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025018 Fup NA 0.2369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025018 Vd NA 3.022 L/kg 1compartment NA NA Rat Human +DTXSID6025018 TK.Half.Life NA 2.515 hours 1compartment NA NA Human Human +DTXSID6025018 Css NA 0.03298 mg/L 3compartmentss NA 50% Human Human +DTXSID6025018 Css NA 0.2961 mg/L 3compartmentss NA 95% Human Human +DTXSID6025018 Css NA 0.03827 mg/L PBTK NA 50% Human Human +DTXSID6025018 Css NA 0.2745 mg/L PBTK NA 95% Human Human +DTXSID6025018 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025018 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025018 Vd NA 2.757 L/kg 1compartment NA NA Rat Human DTXSID6025018 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025018 TK.Half.Life NA 1.76 hours 1compartment NA NA Rat Human -DTXSID6025018 Css NA 0.02256 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025018 Css NA 0.1516 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025018 Css NA 0.02808 mg/L PBTK NA 50% Rat Human -DTXSID6025018 Css NA 0.142 mg/L PBTK NA 95% Rat Human -DTXSID6025064 Clint NA 4.816 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025064 Fup NA 0.7913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025064 Vd NA 1.631 L/kg 1compartment NA NA Human Human +DTXSID6025018 TK.Half.Life NA 1.381 hours 1compartment NA NA Rat Human +DTXSID6025018 Css NA 0.004004 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025018 Css NA 0.02819 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025018 Css NA 0.004838 mg/L PBTK NA 50% Rat Human +DTXSID6025018 Css NA 0.02548 mg/L PBTK NA 95% Rat Human +DTXSID6025064 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025064 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025064 Vd NA 0.9403 L/kg 1compartment NA NA Human Human DTXSID6025064 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025064 TK.Half.Life NA 2.438 hours 1compartment NA NA Human Human -DTXSID6025064 Css NA 0.1144 mg/L 3compartmentss NA 50% Human Human -DTXSID6025064 Css NA 0.9393 mg/L 3compartmentss NA 95% Human Human -DTXSID6025064 Css NA 0.1046 mg/L PBTK NA 50% Human Human -DTXSID6025064 Css NA 0.6651 mg/L PBTK NA 95% Human Human -DTXSID6025064 Clint NA 4.816 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025064 Fup NA 0.7913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025064 Vd NA 1.428 L/kg 1compartment NA NA Rat Human +DTXSID6025064 TK.Half.Life NA 1.245 hours 1compartment NA NA Human Human +DTXSID6025064 Css NA 0.07014 mg/L 3compartmentss NA 50% Human Human +DTXSID6025064 Css NA 0.5238 mg/L 3compartmentss NA 95% Human Human +DTXSID6025064 Css NA 0.05192 mg/L PBTK NA 50% Human Human +DTXSID6025064 Css NA 0.3593 mg/L PBTK NA 95% Human Human +DTXSID6025064 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025064 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025064 Vd NA 0.8145 L/kg 1compartment NA NA Rat Human DTXSID6025064 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025064 TK.Half.Life NA 1.048 hours 1compartment NA NA Rat Human -DTXSID6025064 Css NA 0.05348 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025064 Css NA 0.4008 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025064 Css NA 0.04835 mg/L PBTK NA 50% Rat Human -DTXSID6025064 Css NA 0.2594 mg/L PBTK NA 95% Rat Human +DTXSID6025064 TK.Half.Life NA 0.5622 hours 1compartment NA NA Rat Human +DTXSID6025064 Css NA 0.008789 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025064 Css NA 0.05081 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025064 Css NA 0.006393 mg/L PBTK NA 50% Rat Human +DTXSID6025064 Css NA 0.03373 mg/L PBTK NA 95% Rat Human DTXSID6025141 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6025141 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025141 Vd NA 0.7697 L/kg 1compartment NA NA Human Human +DTXSID6025141 Vd NA 1.029 L/kg 1compartment NA NA Human Human DTXSID6025141 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025141 TK.Half.Life NA 4.983 hours 1compartment NA NA Human Human -DTXSID6025141 Css NA 0.8311 mg/L 3compartmentss NA 50% Human Human -DTXSID6025141 Css NA 5.569 mg/L 3compartmentss NA 95% Human Human -DTXSID6025141 Css NA 0.6988 mg/L PBTK NA 50% Human Human -DTXSID6025141 Css NA 3.648 mg/L PBTK NA 95% Human Human +DTXSID6025141 TK.Half.Life NA 6.756 hours 1compartment NA NA Human Human +DTXSID6025141 Css NA 0.6668 mg/L 3compartmentss NA 50% Human Human +DTXSID6025141 Css NA 4.571 mg/L 3compartmentss NA 95% Human Human +DTXSID6025141 Css NA 0.5968 mg/L PBTK NA 50% Human Human +DTXSID6025141 Css NA 3.01 mg/L PBTK NA 95% Human Human DTXSID6025141 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6025141 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025141 Vd NA 0.8084 L/kg 1compartment NA NA Rat Human +DTXSID6025141 Vd NA 1.025 L/kg 1compartment NA NA Rat Human DTXSID6025141 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025141 TK.Half.Life NA 1.783 hours 1compartment NA NA Rat Human -DTXSID6025141 Css NA 0.2086 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025141 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025141 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID6025141 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID6025141 TK.Half.Life NA 2.267 hours 1compartment NA NA Rat Human +DTXSID6025141 Css NA 0.01189 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025141 Css NA 0.09251 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025141 Css NA 0.01038 mg/L PBTK NA 50% Rat Human +DTXSID6025141 Css NA 0.06404 mg/L PBTK NA 95% Rat Human DTXSID6025143 Clint 40.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6025143 Fup NA 0.3564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025143 Vd NA 2.104 L/kg 1compartment NA NA Human Human +DTXSID6025143 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025143 Vd NA 1.648 L/kg 1compartment NA NA Human Human DTXSID6025143 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025143 TK.Half.Life NA 2.317 hours 1compartment NA NA Human Human -DTXSID6025143 Css NA 0.04737 mg/L 3compartmentss NA 50% Human Human -DTXSID6025143 Css NA 0.3458 mg/L 3compartmentss NA 95% Human Human -DTXSID6025143 Css NA 0.03706 mg/L PBTK NA 50% Human Human -DTXSID6025143 Css NA 0.2498 mg/L PBTK NA 95% Human Human +DTXSID6025143 TK.Half.Life NA 2.25 hours 1compartment NA NA Human Human +DTXSID6025143 Css NA 0.07067 mg/L 3compartmentss NA 50% Human Human +DTXSID6025143 Css NA 0.5239 mg/L 3compartmentss NA 95% Human Human +DTXSID6025143 Css NA 0.05086 mg/L PBTK NA 50% Human Human +DTXSID6025143 Css NA 0.3519 mg/L PBTK NA 95% Human Human DTXSID6025143 Clint 40.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6025143 Fup NA 0.3564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025143 Vd NA 1.655 L/kg 1compartment NA NA Rat Human +DTXSID6025143 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025143 Vd NA 1.288 L/kg 1compartment NA NA Rat Human DTXSID6025143 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025143 TK.Half.Life NA 0.7928 hours 1compartment NA NA Rat Human -DTXSID6025143 Css NA 0.02608 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025143 Css NA 0.1433 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025143 Css NA 0.01971 mg/L PBTK NA 50% Rat Human -DTXSID6025143 Css NA 0.09916 mg/L PBTK NA 95% Rat Human +DTXSID6025143 TK.Half.Life NA 0.8305 hours 1compartment NA NA Rat Human +DTXSID6025143 Css NA 0.009213 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025143 Css NA 0.05091 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025143 Css NA 0.006596 mg/L PBTK NA 50% Rat Human +DTXSID6025143 Css NA 0.035 mg/L PBTK NA 95% Rat Human DTXSID6025145 Clint 33.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6025145 Fup NA 0.326 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025145 Vd NA 1.835 L/kg 1compartment NA NA Human Human +DTXSID6025145 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025145 Vd NA 1.605 L/kg 1compartment NA NA Human Human DTXSID6025145 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025145 TK.Half.Life NA 2.128 hours 1compartment NA NA Human Human -DTXSID6025145 Css NA 0.05522 mg/L 3compartmentss NA 50% Human Human -DTXSID6025145 Css NA 0.3791 mg/L 3compartmentss NA 95% Human Human -DTXSID6025145 Css NA 0.0424 mg/L PBTK NA 50% Human Human -DTXSID6025145 Css NA 0.2707 mg/L PBTK NA 95% Human Human +DTXSID6025145 TK.Half.Life NA 2.102 hours 1compartment NA NA Human Human +DTXSID6025145 Css NA 0.06689 mg/L 3compartmentss NA 50% Human Human +DTXSID6025145 Css NA 0.4855 mg/L 3compartmentss NA 95% Human Human +DTXSID6025145 Css NA 0.04888 mg/L PBTK NA 50% Human Human +DTXSID6025145 Css NA 0.3273 mg/L PBTK NA 95% Human Human DTXSID6025145 Clint 33.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6025145 Fup NA 0.326 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025145 Vd NA 1.458 L/kg 1compartment NA NA Rat Human +DTXSID6025145 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025145 Vd NA 1.271 L/kg 1compartment NA NA Rat Human DTXSID6025145 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025145 TK.Half.Life NA 0.7727 hours 1compartment NA NA Rat Human -DTXSID6025145 Css NA 0.02969 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025145 Css NA 0.1615 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025145 Css NA 0.02213 mg/L PBTK NA 50% Rat Human -DTXSID6025145 Css NA 0.11 mg/L PBTK NA 95% Rat Human -DTXSID6025149 Clint NA 27.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025149 Fup NA 0.5453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025149 Vd NA 1.38 L/kg 1compartment NA NA Human Human -DTXSID6025149 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025149 TK.Half.Life NA 1.183 hours 1compartment NA NA Human Human -DTXSID6025149 Css NA 0.02963 mg/L 3compartmentss NA 50% Human Human -DTXSID6025149 Css NA 0.2927 mg/L 3compartmentss NA 95% Human Human -DTXSID6025149 Css NA 0.02534 mg/L PBTK NA 50% Human Human -DTXSID6025149 Css NA 0.2092 mg/L PBTK NA 95% Human Human -DTXSID6025149 Clint NA 27.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025149 Fup NA 0.5453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025149 Vd NA 1.257 L/kg 1compartment NA NA Rat Human +DTXSID6025145 TK.Half.Life NA 0.7923 hours 1compartment NA NA Rat Human +DTXSID6025145 Css NA 0.008482 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025145 Css NA 0.04753 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025145 Css NA 0.00624 mg/L PBTK NA 50% Rat Human +DTXSID6025145 Css NA 0.03243 mg/L PBTK NA 95% Rat Human +DTXSID6025149 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025149 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025149 Vd NA 1.494 L/kg 1compartment NA NA Human Human +DTXSID6025149 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6025149 TK.Half.Life NA 17.15 hours 1compartment NA NA Human Human +DTXSID6025149 Css NA 1.105 mg/L 3compartmentss NA 50% Human Human +DTXSID6025149 Css NA 7.856 mg/L 3compartmentss NA 95% Human Human +DTXSID6025149 Css NA 0.9944 mg/L PBTK NA 50% Human Human +DTXSID6025149 Css NA 5.169 mg/L PBTK NA 95% Human Human +DTXSID6025149 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025149 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025149 Vd NA 1.364 L/kg 1compartment NA NA Rat Human DTXSID6025149 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025149 TK.Half.Life NA 0.5227 hours 1compartment NA NA Rat Human -DTXSID6025149 Css NA 0.01557 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025149 Css NA 0.1317 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025149 Css NA 0.01302 mg/L PBTK NA 50% Rat Human -DTXSID6025149 Css NA 0.08914 mg/L PBTK NA 95% Rat Human +DTXSID6025149 TK.Half.Life NA 4.937 hours 1compartment NA NA Rat Human +DTXSID6025149 Css NA 0.06729 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025149 Css NA 0.4653 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025149 Css NA 0.06076 mg/L PBTK NA 50% Rat Human +DTXSID6025149 Css NA 0.2935 mg/L PBTK NA 95% Rat Human DTXSID6025226 Clint 6.02 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6025226 Fup 0.00553 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6025226 Vd NA 1.687 L/kg 1compartment NA NA Human Human -DTXSID6025226 Days.Css NA 24 Days PBTK NA NA Human Human -DTXSID6025226 TK.Half.Life NA 124.1 hours 1compartment NA NA Human Human -DTXSID6025226 Css NA 8.403 mg/L 3compartmentss NA 50% Human Human -DTXSID6025226 Css NA 59.76 mg/L 3compartmentss NA 95% Human Human -DTXSID6025226 Css NA 5.388 mg/L PBTK NA 50% Human Human -DTXSID6025226 Css NA 36.99 mg/L PBTK NA 95% Human Human +DTXSID6025226 Vd NA 0.1691 L/kg 1compartment NA NA Human Human +DTXSID6025226 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6025226 TK.Half.Life NA 18.19 hours 1compartment NA NA Human Human +DTXSID6025226 Css NA 11.06 mg/L 3compartmentss NA 50% Human Human +DTXSID6025226 Css NA 72.64 mg/L 3compartmentss NA 95% Human Human +DTXSID6025226 Css NA 6.479 mg/L PBTK NA 50% Human Human +DTXSID6025226 Css NA 42.61 mg/L PBTK NA 95% Human Human DTXSID6025226 Clint 6.02 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6025226 Fup 0.00553 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6025226 Vd NA 1.245 L/kg 1compartment NA NA Rat Human -DTXSID6025226 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID6025226 TK.Half.Life NA 44.07 hours 1compartment NA NA Rat Human -DTXSID6025226 Css NA 4.74 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025226 Css NA 23.76 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025226 Css NA 2.878 mg/L PBTK NA 50% Rat Human -DTXSID6025226 Css NA 13.82 mg/L PBTK NA 95% Rat Human -DTXSID6025272 Clint NA 16.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025272 Fup NA 0.2742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025272 Vd NA 2.026 L/kg 1compartment NA NA Human Human +DTXSID6025226 Vd NA 0.1673 L/kg 1compartment NA NA Rat Human +DTXSID6025226 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6025226 TK.Half.Life NA 11.48 hours 1compartment NA NA Rat Human +DTXSID6025226 Css NA 1.385 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025226 Css NA 6.652 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025226 Css NA 0.7796 mg/L PBTK NA 50% Rat Human +DTXSID6025226 Css NA 3.732 mg/L PBTK NA 95% Rat Human +DTXSID6025272 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025272 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025272 Vd NA 1.627 L/kg 1compartment NA NA Human Human DTXSID6025272 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025272 TK.Half.Life NA 3.97 hours 1compartment NA NA Human Human -DTXSID6025272 Css NA 0.1508 mg/L 3compartmentss NA 50% Human Human -DTXSID6025272 Css NA 0.9242 mg/L 3compartmentss NA 95% Human Human -DTXSID6025272 Css NA 0.1128 mg/L PBTK NA 50% Human Human -DTXSID6025272 Css NA 0.6482 mg/L PBTK NA 95% Human Human -DTXSID6025272 Clint NA 16.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025272 Fup NA 0.2742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025272 Vd NA 1.581 L/kg 1compartment NA NA Rat Human +DTXSID6025272 TK.Half.Life NA 3.411 hours 1compartment NA NA Human Human +DTXSID6025272 Css NA 0.1709 mg/L 3compartmentss NA 50% Human Human +DTXSID6025272 Css NA 1.181 mg/L 3compartmentss NA 95% Human Human +DTXSID6025272 Css NA 0.1194 mg/L PBTK NA 50% Human Human +DTXSID6025272 Css NA 0.7755 mg/L PBTK NA 95% Human Human +DTXSID6025272 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025272 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025272 Vd NA 1.262 L/kg 1compartment NA NA Rat Human DTXSID6025272 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025272 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Human -DTXSID6025272 Css NA 0.08092 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025272 Css NA 0.3761 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025272 Css NA 0.05839 mg/L PBTK NA 50% Rat Human -DTXSID6025272 Css NA 0.2592 mg/L PBTK NA 95% Rat Human +DTXSID6025272 TK.Half.Life NA 1.287 hours 1compartment NA NA Rat Human +DTXSID6025272 Css NA 0.02212 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025272 Css NA 0.1193 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025272 Css NA 0.01522 mg/L PBTK NA 50% Rat Human +DTXSID6025272 Css NA 0.07751 mg/L PBTK NA 95% Rat Human +DTXSID6025276 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025276 Fup 0.466 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025276 Vd NA 1.242 L/kg 1compartment NA NA Human Human +DTXSID6025276 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6025276 TK.Half.Life NA 17.24 hours 1compartment NA NA Human Human +DTXSID6025276 Css NA 1.143 mg/L 3compartmentss NA 50% Human Human +DTXSID6025276 Css NA 6.141 mg/L 3compartmentss NA 95% Human Human +DTXSID6025276 Css NA 0.9932 mg/L PBTK NA 50% Human Human +DTXSID6025276 Css NA 4.143 mg/L PBTK NA 95% Human Human +DTXSID6025276 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025276 Fup 0.466 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025276 Vd NA 1.221 L/kg 1compartment NA NA Rat Human +DTXSID6025276 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6025276 TK.Half.Life NA 5.776 hours 1compartment NA NA Rat Human +DTXSID6025276 Css NA 0.02099 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025276 Css NA 0.1533 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025276 Css NA 0.01782 mg/L PBTK NA 50% Rat Human +DTXSID6025276 Css NA 0.1066 mg/L PBTK NA 95% Rat Human DTXSID6025278 Clint NA 14.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6025278 Fup NA 0.7935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025278 Vd NA 1.331 L/kg 1compartment NA NA Human Human +DTXSID6025278 Vd NA 1.069 L/kg 1compartment NA NA Human Human DTXSID6025278 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025278 TK.Half.Life NA 1.136 hours 1compartment NA NA Human Human -DTXSID6025278 Css NA 0.03984 mg/L 3compartmentss NA 50% Human Human -DTXSID6025278 Css NA 0.3853 mg/L 3compartmentss NA 95% Human Human -DTXSID6025278 Css NA 0.03521 mg/L PBTK NA 50% Human Human -DTXSID6025278 Css NA 0.2807 mg/L PBTK NA 95% Human Human +DTXSID6025278 TK.Half.Life NA 0.9092 hours 1compartment NA NA Human Human +DTXSID6025278 Css NA 0.03044 mg/L 3compartmentss NA 50% Human Human +DTXSID6025278 Css NA 0.3314 mg/L 3compartmentss NA 95% Human Human +DTXSID6025278 Css NA 0.02636 mg/L PBTK NA 50% Human Human +DTXSID6025278 Css NA 0.2388 mg/L PBTK NA 95% Human Human DTXSID6025278 Clint NA 14.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6025278 Fup NA 0.7935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025278 Vd NA 1.217 L/kg 1compartment NA NA Rat Human +DTXSID6025278 Vd NA 1.024 L/kg 1compartment NA NA Rat Human DTXSID6025278 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025278 TK.Half.Life NA 0.5104 hours 1compartment NA NA Rat Human -DTXSID6025278 Css NA 0.01995 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025278 Css NA 0.1594 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025278 Css NA 0.01754 mg/L PBTK NA 50% Rat Human -DTXSID6025278 Css NA 0.1088 mg/L PBTK NA 95% Rat Human -DTXSID6025305 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025305 Fup NA 0.8822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025305 Vd NA 0.9614 L/kg 1compartment NA NA Human Human +DTXSID6025278 TK.Half.Life NA 0.4338 hours 1compartment NA NA Rat Human +DTXSID6025278 Css NA 0.001056 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025278 Css NA 0.0136 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025278 Css NA 0.0009036 mg/L PBTK NA 50% Rat Human +DTXSID6025278 Css NA 0.009364 mg/L PBTK NA 95% Rat Human +DTXSID6025301 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025301 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human +DTXSID6025301 Vd NA 3.145 L/kg 1compartment NA NA Human Human +DTXSID6025301 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6025301 TK.Half.Life NA 17.39 hours 1compartment NA NA Human Human +DTXSID6025301 Css NA 0.5484 mg/L 3compartmentss NA 50% Human Human +DTXSID6025301 Css NA 3.48 mg/L 3compartmentss NA 95% Human Human +DTXSID6025301 Css NA 0.3981 mg/L PBTK NA 50% Human Human +DTXSID6025301 Css NA 2.374 mg/L PBTK NA 95% Human Human +DTXSID6025301 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025301 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human +DTXSID6025301 Vd NA 2.376 L/kg 1compartment NA NA Rat Human +DTXSID6025301 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6025301 TK.Half.Life NA 2.746 hours 1compartment NA NA Rat Human +DTXSID6025301 Css NA 0.06958 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025301 Css NA 0.3463 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025301 Css NA 0.05014 mg/L PBTK NA 50% Rat Human +DTXSID6025301 Css NA 0.2428 mg/L PBTK NA 95% Rat Human +DTXSID6025303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025303 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025303 Vd NA 2.747 L/kg 1compartment NA NA Human Human +DTXSID6025303 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6025303 TK.Half.Life NA 7.62 hours 1compartment NA NA Human Human +DTXSID6025303 Css NA 0.236 mg/L 3compartmentss NA 50% Human Human +DTXSID6025303 Css NA 1.47 mg/L 3compartmentss NA 95% Human Human +DTXSID6025303 Css NA 0.1735 mg/L PBTK NA 50% Human Human +DTXSID6025303 Css NA 1.038 mg/L PBTK NA 95% Human Human +DTXSID6025303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025303 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025303 Vd NA 2.091 L/kg 1compartment NA NA Rat Human +DTXSID6025303 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6025303 TK.Half.Life NA 1.856 hours 1compartment NA NA Rat Human +DTXSID6025303 Css NA 0.02974 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025303 Css NA 0.146 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025303 Css NA 0.02182 mg/L PBTK NA 50% Rat Human +DTXSID6025303 Css NA 0.1023 mg/L PBTK NA 95% Rat Human +DTXSID6025305 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025305 Fup 0.872 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025305 Vd NA 1.029 L/kg 1compartment NA NA Human Human DTXSID6025305 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025305 TK.Half.Life NA 7.149 hours 1compartment NA NA Human Human -DTXSID6025305 Css NA 0.8986 mg/L 3compartmentss NA 50% Human Human -DTXSID6025305 Css NA 5.38 mg/L 3compartmentss NA 95% Human Human -DTXSID6025305 Css NA 0.7758 mg/L PBTK NA 50% Human Human -DTXSID6025305 Css NA 3.546 mg/L PBTK NA 95% Human Human -DTXSID6025305 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025305 Fup NA 0.8822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025305 Vd NA 0.9556 L/kg 1compartment NA NA Rat Human +DTXSID6025305 TK.Half.Life NA 0.7457 hours 1compartment NA NA Human Human +DTXSID6025305 Css NA 0.01865 mg/L 3compartmentss NA 50% Human Human +DTXSID6025305 Css NA 0.2335 mg/L 3compartmentss NA 95% Human Human +DTXSID6025305 Css NA 0.0161 mg/L PBTK NA 50% Human Human +DTXSID6025305 Css NA 0.1666 mg/L PBTK NA 95% Human Human +DTXSID6025305 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025305 Fup 0.872 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025305 Vd NA 1.006 L/kg 1compartment NA NA Rat Human DTXSID6025305 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025305 TK.Half.Life NA 2.397 hours 1compartment NA NA Rat Human -DTXSID6025305 Css NA 0.2276 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025305 Css NA 1.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025305 Css NA 0.193 mg/L PBTK NA 50% Rat Human -DTXSID6025305 Css NA 0.8161 mg/L PBTK NA 95% Rat Human -DTXSID6025307 Clint NA 56.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025307 Fup NA 0.0119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025307 Vd NA 16.08 L/kg 1compartment NA NA Human Human -DTXSID6025307 Days.Css NA 34 Days PBTK NA NA Human Human -DTXSID6025307 TK.Half.Life NA 188.5 hours 1compartment NA NA Human Human -DTXSID6025307 Css NA 0.5422 mg/L 3compartmentss NA 50% Human Human -DTXSID6025307 Css NA 3.153 mg/L 3compartmentss NA 95% Human Human -DTXSID6025307 Css NA 0.9426 mg/L PBTK NA 50% Human Human -DTXSID6025307 Css NA 5.244 mg/L PBTK NA 95% Human Human -DTXSID6025307 Clint NA 56.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025307 Fup NA 0.0119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025307 Vd NA 12.93 L/kg 1compartment NA NA Rat Human -DTXSID6025307 Days.Css NA 22 Days PBTK NA NA Rat Human -DTXSID6025307 TK.Half.Life NA 27.35 hours 1compartment NA NA Rat Human -DTXSID6025307 Css NA 0.2912 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025307 Css NA 1.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025307 Css NA 0.5148 mg/L PBTK NA 50% Rat Human -DTXSID6025307 Css NA 2.143 mg/L PBTK NA 95% Rat Human -DTXSID6025355 Clint NA 5.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025355 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025355 Vd NA 0.9151 L/kg 1compartment NA NA Human Human +DTXSID6025305 TK.Half.Life NA 0.351 hours 1compartment NA NA Rat Human +DTXSID6025305 Css NA 0.0006685 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025305 Css NA 0.008333 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025305 Css NA 0.0005731 mg/L PBTK NA 50% Rat Human +DTXSID6025305 Css NA 0.005896 mg/L PBTK NA 95% Rat Human +DTXSID6025309 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025309 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025309 Vd NA 0.9259 L/kg 1compartment NA NA Human Human +DTXSID6025309 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6025309 TK.Half.Life NA 7.915 hours 1compartment NA NA Human Human +DTXSID6025309 Css NA 0.839 mg/L 3compartmentss NA 50% Human Human +DTXSID6025309 Css NA 5.689 mg/L 3compartmentss NA 95% Human Human +DTXSID6025309 Css NA 0.7188 mg/L PBTK NA 50% Human Human +DTXSID6025309 Css NA 3.708 mg/L PBTK NA 95% Human Human +DTXSID6025309 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025309 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025309 Vd NA 0.9113 L/kg 1compartment NA NA Rat Human +DTXSID6025309 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6025309 TK.Half.Life NA 2.624 hours 1compartment NA NA Rat Human +DTXSID6025309 Css NA 0.01554 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025309 Css NA 0.131 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025309 Css NA 0.01291 mg/L PBTK NA 50% Rat Human +DTXSID6025309 Css NA 0.08386 mg/L PBTK NA 95% Rat Human +DTXSID6025355 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025355 Fup 0.734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025355 Vd NA 0.7231 L/kg 1compartment NA NA Human Human DTXSID6025355 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025355 TK.Half.Life NA 0.9533 hours 1compartment NA NA Human Human -DTXSID6025355 Css NA 0.07675 mg/L 3compartmentss NA 50% Human Human -DTXSID6025355 Css NA 0.7756 mg/L 3compartmentss NA 95% Human Human -DTXSID6025355 Css NA 0.06607 mg/L PBTK NA 50% Human Human -DTXSID6025355 Css NA 0.5562 mg/L PBTK NA 95% Human Human -DTXSID6025355 Clint NA 5.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025355 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025355 Vd NA 0.9325 L/kg 1compartment NA NA Rat Human +DTXSID6025355 TK.Half.Life NA 6.388 hours 1compartment NA NA Human Human +DTXSID6025355 Css NA 0.9053 mg/L 3compartmentss NA 50% Human Human +DTXSID6025355 Css NA 5.856 mg/L 3compartmentss NA 95% Human Human +DTXSID6025355 Css NA 0.7358 mg/L PBTK NA 50% Human Human +DTXSID6025355 Css NA 3.734 mg/L PBTK NA 95% Human Human +DTXSID6025355 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025355 Fup 0.734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025355 Vd NA 0.7424 L/kg 1compartment NA NA Rat Human DTXSID6025355 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025355 TK.Half.Life NA 0.5037 hours 1compartment NA NA Rat Human -DTXSID6025355 Css NA 0.03612 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025355 Css NA 0.2794 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025355 Css NA 0.03095 mg/L PBTK NA 50% Rat Human -DTXSID6025355 Css NA 0.1823 mg/L PBTK NA 95% Rat Human +DTXSID6025355 TK.Half.Life NA 2.232 hours 1compartment NA NA Rat Human +DTXSID6025355 Css NA 0.01696 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025355 Css NA 0.1368 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025355 Css NA 0.01348 mg/L PBTK NA 50% Rat Human +DTXSID6025355 Css NA 0.08714 mg/L PBTK NA 95% Rat Human DTXSID6025432 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6025432 Fup NA 0.7738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6025432 Vd NA 0.6753 L/kg 1compartment NA NA Human Human DTXSID6025432 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6025432 TK.Half.Life NA 5.649 hours 1compartment NA NA Human Human -DTXSID6025432 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human -DTXSID6025432 Css NA 6.151 mg/L 3compartmentss NA 95% Human Human -DTXSID6025432 Css NA 0.8295 mg/L PBTK NA 50% Human Human -DTXSID6025432 Css NA 3.966 mg/L PBTK NA 95% Human Human +DTXSID6025432 Css NA 0.8748 mg/L 3compartmentss NA 50% Human Human +DTXSID6025432 Css NA 5.494 mg/L 3compartmentss NA 95% Human Human +DTXSID6025432 Css NA 0.7062 mg/L PBTK NA 50% Human Human +DTXSID6025432 Css NA 3.546 mg/L PBTK NA 95% Human Human DTXSID6025432 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6025432 Fup NA 0.7738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6025432 Vd NA 0.7051 L/kg 1compartment NA NA Rat Human DTXSID6025432 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6025432 TK.Half.Life NA 2.01 hours 1compartment NA NA Rat Human -DTXSID6025432 Css NA 0.263 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025432 Css NA 1.616 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025432 Css NA 0.2056 mg/L PBTK NA 50% Rat Human -DTXSID6025432 Css NA 0.9569 mg/L PBTK NA 95% Rat Human -DTXSID6025436 Clint NA 7.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025436 Fup NA 0.2366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025436 Vd NA 1.225 L/kg 1compartment NA NA Human Human +DTXSID6025432 Css NA 0.01617 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025432 Css NA 0.1328 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025432 Css NA 0.01268 mg/L PBTK NA 50% Rat Human +DTXSID6025432 Css NA 0.08428 mg/L PBTK NA 95% Rat Human +DTXSID6025436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025436 Fup 0.417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025436 Vd NA 0.5142 L/kg 1compartment NA NA Human Human DTXSID6025436 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025436 TK.Half.Life NA 3.595 hours 1compartment NA NA Human Human -DTXSID6025436 Css NA 0.2716 mg/L 3compartmentss NA 50% Human Human -DTXSID6025436 Css NA 1.631 mg/L 3compartmentss NA 95% Human Human -DTXSID6025436 Css NA 0.198 mg/L PBTK NA 50% Human Human -DTXSID6025436 Css NA 1.11 mg/L PBTK NA 95% Human Human -DTXSID6025436 Clint NA 7.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025436 Fup NA 0.2366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025436 Vd NA 0.9998 L/kg 1compartment NA NA Rat Human +DTXSID6025436 TK.Half.Life NA 7.986 hours 1compartment NA NA Human Human +DTXSID6025436 Css NA 1.731 mg/L 3compartmentss NA 50% Human Human +DTXSID6025436 Css NA 7.457 mg/L 3compartmentss NA 95% Human Human +DTXSID6025436 Css NA 1.264 mg/L PBTK NA 50% Human Human +DTXSID6025436 Css NA 4.69 mg/L PBTK NA 95% Human Human +DTXSID6025436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025436 Fup 0.417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025436 Vd NA 0.5277 L/kg 1compartment NA NA Rat Human DTXSID6025436 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025436 TK.Half.Life NA 1.564 hours 1compartment NA NA Rat Human -DTXSID6025436 Css NA 0.1441 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025436 Css NA 0.6192 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025436 Css NA 0.09996 mg/L PBTK NA 50% Rat Human -DTXSID6025436 Css NA 0.396 mg/L PBTK NA 95% Rat Human +DTXSID6025436 TK.Half.Life NA 2.79 hours 1compartment NA NA Rat Human +DTXSID6025436 Css NA 0.1097 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025436 Css NA 0.4007 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025436 Css NA 0.07896 mg/L PBTK NA 50% Rat Human +DTXSID6025436 Css NA 0.245 mg/L PBTK NA 95% Rat Human DTXSID6025438 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6025438 Fup 1.05e-05 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6025438 Vd NA 0.1592 L/kg 1compartment NA NA Human Human DTXSID6025438 Days.Css NA 2835 Days PBTK NA NA Human Human DTXSID6025438 TK.Half.Life NA 10300 hours 1compartment NA NA Human Human -DTXSID6025438 Css NA 77.18 mg/L 3compartmentss NA 50% Human Human -DTXSID6025438 Css NA 933 mg/L 3compartmentss NA 95% Human Human -DTXSID6025438 Css NA 45.44 mg/L PBTK NA 50% Human Human -DTXSID6025438 Css NA 544.6 mg/L PBTK NA 95% Human Human +DTXSID6025438 Css NA 64.91 mg/L 3compartmentss NA 50% Human Human +DTXSID6025438 Css NA 802.7 mg/L 3compartmentss NA 95% Human Human +DTXSID6025438 Css NA 37.83 mg/L PBTK NA 50% Human Human +DTXSID6025438 Css NA 468.5 mg/L PBTK NA 95% Human Human DTXSID6025438 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6025438 Fup 1.05e-05 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6025438 Vd NA 0.1578 L/kg 1compartment NA NA Rat Human -DTXSID6025438 Days.Css NA 651 Days PBTK NA NA Rat Human +DTXSID6025438 Days.Css NA 959 Days PBTK NA NA Rat Human DTXSID6025438 TK.Half.Life NA 3480 hours 1compartment NA NA Rat Human -DTXSID6025438 Css NA 23.86 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025438 Css NA 265.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025438 Css NA 12.97 mg/L PBTK NA 50% Rat Human -DTXSID6025438 Css NA 143.4 mg/L PBTK NA 95% Rat Human +DTXSID6025438 Css NA 1.168 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025438 Css NA 19.62 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025438 Css NA 0.6438 mg/L PBTK NA 50% Rat Human +DTXSID6025438 Css NA 10.84 mg/L PBTK NA 95% Rat Human DTXSID6025486 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6025486 Fup 0.609 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6025486 Vd NA 2.379 L/kg 1compartment NA NA Human Human -DTXSID6025486 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6025486 TK.Half.Life NA 25.29 hours 1compartment NA NA Human Human -DTXSID6025486 Css NA 0.8334 mg/L 3compartmentss NA 50% Human Human -DTXSID6025486 Css NA 3.523 mg/L 3compartmentss NA 95% Human Human -DTXSID6025486 Css NA 0.8986 mg/L PBTK NA 50% Human Human -DTXSID6025486 Css NA 2.855 mg/L PBTK NA 95% Human Human +DTXSID6025486 Vd NA 1.033 L/kg 1compartment NA NA Human Human +DTXSID6025486 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6025486 TK.Half.Life NA 10.97 hours 1compartment NA NA Human Human +DTXSID6025486 Css NA 0.7114 mg/L 3compartmentss NA 50% Human Human +DTXSID6025486 Css NA 2.819 mg/L 3compartmentss NA 95% Human Human +DTXSID6025486 Css NA 0.6284 mg/L PBTK NA 50% Human Human +DTXSID6025486 Css NA 2.047 mg/L PBTK NA 95% Human Human DTXSID6025486 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6025486 Fup 0.609 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6025486 Vd NA 2.407 L/kg 1compartment NA NA Rat Human +DTXSID6025486 Vd NA 1.076 L/kg 1compartment NA NA Rat Human DTXSID6025486 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025486 TK.Half.Life NA 8.717 hours 1compartment NA NA Rat Human -DTXSID6025486 Css NA 0.218 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025486 Css NA 0.8181 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025486 Css NA 0.2338 mg/L PBTK NA 50% Rat Human -DTXSID6025486 Css NA 0.6091 mg/L PBTK NA 95% Rat Human -DTXSID6025513 Clint NA 9.304 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025513 Fup NA 0.5663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025513 Vd NA 5.546 L/kg 1compartment NA NA Human Human +DTXSID6025486 TK.Half.Life NA 3.894 hours 1compartment NA NA Rat Human +DTXSID6025486 Css NA 0.00532 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025486 Css NA 0.03136 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025486 Css NA 0.004523 mg/L PBTK NA 50% Rat Human +DTXSID6025486 Css NA 0.02382 mg/L PBTK NA 95% Rat Human +DTXSID6025513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025513 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025513 Vd NA 0.6067 L/kg 1compartment NA NA Human Human DTXSID6025513 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025513 TK.Half.Life NA 6.194 hours 1compartment NA NA Human Human -DTXSID6025513 Css NA 0.0502 mg/L 3compartmentss NA 50% Human Human -DTXSID6025513 Css NA 0.3761 mg/L 3compartmentss NA 95% Human Human -DTXSID6025513 Css NA 0.06226 mg/L PBTK NA 50% Human Human -DTXSID6025513 Css NA 0.3965 mg/L PBTK NA 95% Human Human -DTXSID6025513 Clint NA 9.304 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025513 Fup NA 0.5663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025513 Vd NA 5.075 L/kg 1compartment NA NA Rat Human +DTXSID6025513 TK.Half.Life NA 1.243 hours 1compartment NA NA Human Human +DTXSID6025513 Css NA 0.1862 mg/L 3compartmentss NA 50% Human Human +DTXSID6025513 Css NA 1.604 mg/L 3compartmentss NA 95% Human Human +DTXSID6025513 Css NA 0.1214 mg/L PBTK NA 50% Human Human +DTXSID6025513 Css NA 0.9887 mg/L PBTK NA 95% Human Human +DTXSID6025513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025513 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025513 Vd NA 0.6044 L/kg 1compartment NA NA Rat Human DTXSID6025513 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025513 TK.Half.Life NA 1.703 hours 1compartment NA NA Rat Human -DTXSID6025513 Css NA 0.02638 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025513 Css NA 0.1633 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025513 Css NA 0.03336 mg/L PBTK NA 50% Rat Human -DTXSID6025513 Css NA 0.175 mg/L PBTK NA 95% Rat Human -DTXSID6025565 Clint NA 8.673 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025565 Fup NA 0.6808 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025565 Vd NA 1.476 L/kg 1compartment NA NA Human Human +DTXSID6025513 TK.Half.Life NA 0.7152 hours 1compartment NA NA Rat Human +DTXSID6025513 Css NA 0.02376 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025513 Css NA 0.147 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025513 Css NA 0.01527 mg/L PBTK NA 50% Rat Human +DTXSID6025513 Css NA 0.09004 mg/L PBTK NA 95% Rat Human +DTXSID6025565 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025565 Fup 0.538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025565 Vd NA 0.9164 L/kg 1compartment NA NA Human Human DTXSID6025565 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025565 TK.Half.Life NA 1.742 hours 1compartment NA NA Human Human -DTXSID6025565 Css NA 0.07437 mg/L 3compartmentss NA 50% Human Human -DTXSID6025565 Css NA 0.6917 mg/L 3compartmentss NA 95% Human Human -DTXSID6025565 Css NA 0.06601 mg/L PBTK NA 50% Human Human -DTXSID6025565 Css NA 0.4987 mg/L PBTK NA 95% Human Human -DTXSID6025565 Clint NA 8.673 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025565 Fup NA 0.6808 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025565 Vd NA 1.328 L/kg 1compartment NA NA Rat Human +DTXSID6025565 TK.Half.Life NA 0.8631 hours 1compartment NA NA Human Human +DTXSID6025565 Css NA 0.03516 mg/L 3compartmentss NA 50% Human Human +DTXSID6025565 Css NA 0.3567 mg/L 3compartmentss NA 95% Human Human +DTXSID6025565 Css NA 0.02849 mg/L PBTK NA 50% Human Human +DTXSID6025565 Css NA 0.2531 mg/L PBTK NA 95% Human Human +DTXSID6025565 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025565 Fup 0.538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025565 Vd NA 0.88 L/kg 1compartment NA NA Rat Human DTXSID6025565 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025565 TK.Half.Life NA 0.7943 hours 1compartment NA NA Rat Human -DTXSID6025565 Css NA 0.03632 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025565 Css NA 0.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025565 Css NA 0.03188 mg/L PBTK NA 50% Rat Human -DTXSID6025565 Css NA 0.1916 mg/L PBTK NA 95% Rat Human +DTXSID6025565 TK.Half.Life NA 0.4151 hours 1compartment NA NA Rat Human +DTXSID6025565 Css NA 0.004389 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025565 Css NA 0.03483 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025565 Css NA 0.003574 mg/L PBTK NA 50% Rat Human +DTXSID6025565 Css NA 0.02335 mg/L PBTK NA 95% Rat Human DTXSID6025567 Clint 246 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6025567 Fup 0.224 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6025567 Vd NA 1.06 L/kg 1compartment NA NA Human Human DTXSID6025567 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6025567 TK.Half.Life NA 0.8967 hours 1compartment NA NA Human Human -DTXSID6025567 Css NA 0.008867 mg/L 3compartmentss NA 50% Human Human -DTXSID6025567 Css NA 0.05779 mg/L 3compartmentss NA 95% Human Human -DTXSID6025567 Css NA 0.00635 mg/L PBTK NA 50% Human Human -DTXSID6025567 Css NA 0.03857 mg/L PBTK NA 95% Human Human +DTXSID6025567 Css NA 0.006771 mg/L 3compartmentss NA 50% Human Human +DTXSID6025567 Css NA 0.05463 mg/L 3compartmentss NA 95% Human Human +DTXSID6025567 Css NA 0.00483 mg/L PBTK NA 50% Human Human +DTXSID6025567 Css NA 0.03656 mg/L PBTK NA 95% Human Human DTXSID6025567 Clint 246 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6025567 Fup 0.224 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6025567 Vd NA 0.8771 L/kg 1compartment NA NA Rat Human DTXSID6025567 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6025567 TK.Half.Life NA 0.3345 hours 1compartment NA NA Rat Human -DTXSID6025567 Css NA 0.004932 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025567 Css NA 0.02723 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025567 Css NA 0.003369 mg/L PBTK NA 50% Rat Human -DTXSID6025567 Css NA 0.01815 mg/L PBTK NA 95% Rat Human -DTXSID6025569 Clint NA 0.6258 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025569 Fup NA 0.7715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025569 Vd NA 1.045 L/kg 1compartment NA NA Human Human +DTXSID6025567 Css NA 0.0009196 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025567 Css NA 0.005907 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025567 Css NA 0.0006552 mg/L PBTK NA 50% Rat Human +DTXSID6025567 Css NA 0.004081 mg/L PBTK NA 95% Rat Human +DTXSID6025569 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025569 Fup 0.308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025569 Vd NA 0.6115 L/kg 1compartment NA NA Human Human DTXSID6025569 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025569 TK.Half.Life NA 4.578 hours 1compartment NA NA Human Human -DTXSID6025569 Css NA 0.4736 mg/L 3compartmentss NA 50% Human Human -DTXSID6025569 Css NA 3.077 mg/L 3compartmentss NA 95% Human Human -DTXSID6025569 Css NA 0.4114 mg/L PBTK NA 50% Human Human -DTXSID6025569 Css NA 2.032 mg/L PBTK NA 95% Human Human -DTXSID6025569 Clint NA 0.6258 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025569 Fup NA 0.7715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025569 Vd NA 1.003 L/kg 1compartment NA NA Rat Human +DTXSID6025569 TK.Half.Life NA 1.525 hours 1compartment NA NA Human Human +DTXSID6025569 Css NA 0.2156 mg/L 3compartmentss NA 50% Human Human +DTXSID6025569 Css NA 1.414 mg/L 3compartmentss NA 95% Human Human +DTXSID6025569 Css NA 0.1544 mg/L PBTK NA 50% Human Human +DTXSID6025569 Css NA 0.9065 mg/L PBTK NA 95% Human Human +DTXSID6025569 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025569 Fup 0.308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025569 Vd NA 0.5824 L/kg 1compartment NA NA Rat Human DTXSID6025569 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025569 TK.Half.Life NA 1.944 hours 1compartment NA NA Rat Human -DTXSID6025569 Css NA 0.1649 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025569 Css NA 1.098 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025569 Css NA 0.1413 mg/L PBTK NA 50% Rat Human -DTXSID6025569 Css NA 0.6717 mg/L PBTK NA 95% Rat Human -DTXSID6025640 Clint NA 0.9199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025640 Fup NA 0.1427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025640 Vd NA 0.4139 L/kg 1compartment NA NA Human Human -DTXSID6025640 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025640 TK.Half.Life NA 7.551 hours 1compartment NA NA Human Human -DTXSID6025640 Css NA 2.559 mg/L 3compartmentss NA 50% Human Human -DTXSID6025640 Css NA 13.13 mg/L 3compartmentss NA 95% Human Human -DTXSID6025640 Css NA 1.682 mg/L PBTK NA 50% Human Human -DTXSID6025640 Css NA 7.91 mg/L PBTK NA 95% Human Human -DTXSID6025640 Clint NA 0.9199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025640 Fup NA 0.1427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025640 Vd NA 0.4113 L/kg 1compartment NA NA Rat Human +DTXSID6025569 TK.Half.Life NA 0.8237 hours 1compartment NA NA Rat Human +DTXSID6025569 Css NA 0.02558 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025569 Css NA 0.121 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025569 Css NA 0.01809 mg/L PBTK NA 50% Rat Human +DTXSID6025569 Css NA 0.07586 mg/L PBTK NA 95% Rat Human +DTXSID6025640 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025640 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025640 Vd NA 0.5248 L/kg 1compartment NA NA Human Human +DTXSID6025640 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6025640 TK.Half.Life NA 15.09 hours 1compartment NA NA Human Human +DTXSID6025640 Css NA 3.182 mg/L 3compartmentss NA 50% Human Human +DTXSID6025640 Css NA 12.38 mg/L 3compartmentss NA 95% Human Human +DTXSID6025640 Css NA 2.274 mg/L PBTK NA 50% Human Human +DTXSID6025640 Css NA 7.816 mg/L PBTK NA 95% Human Human +DTXSID6025640 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025640 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025640 Vd NA 0.5237 L/kg 1compartment NA NA Rat Human DTXSID6025640 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025640 TK.Half.Life NA 3.677 hours 1compartment NA NA Rat Human -DTXSID6025640 Css NA 1.042 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025640 Css NA 4.574 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025640 Css NA 0.6472 mg/L PBTK NA 50% Rat Human -DTXSID6025640 Css NA 2.563 mg/L PBTK NA 95% Rat Human -DTXSID6025642 Clint NA 1.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025642 Fup NA 0.1111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025642 Vd NA 0.3899 L/kg 1compartment NA NA Human Human +DTXSID6025640 TK.Half.Life NA 5.131 hours 1compartment NA NA Rat Human +DTXSID6025640 Css NA 0.2042 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025640 Css NA 0.6689 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025640 Css NA 0.1434 mg/L PBTK NA 50% Rat Human +DTXSID6025640 Css NA 0.4078 mg/L PBTK NA 95% Rat Human +DTXSID6025642 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025642 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025642 Vd NA 0.3779 L/kg 1compartment NA NA Human Human DTXSID6025642 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025642 TK.Half.Life NA 6.4 hours 1compartment NA NA Human Human -DTXSID6025642 Css NA 2.454 mg/L 3compartmentss NA 50% Human Human -DTXSID6025642 Css NA 14.05 mg/L 3compartmentss NA 95% Human Human -DTXSID6025642 Css NA 1.592 mg/L PBTK NA 50% Human Human -DTXSID6025642 Css NA 8.418 mg/L PBTK NA 95% Human Human -DTXSID6025642 Clint NA 1.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025642 Fup NA 0.1111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025642 Vd NA 0.3842 L/kg 1compartment NA NA Rat Human +DTXSID6025642 TK.Half.Life NA 0.9473 hours 1compartment NA NA Human Human +DTXSID6025642 Css NA 0.2697 mg/L 3compartmentss NA 50% Human Human +DTXSID6025642 Css NA 2.189 mg/L 3compartmentss NA 95% Human Human +DTXSID6025642 Css NA 0.1726 mg/L PBTK NA 50% Human Human +DTXSID6025642 Css NA 1.345 mg/L PBTK NA 95% Human Human +DTXSID6025642 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025642 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025642 Vd NA 0.3721 L/kg 1compartment NA NA Rat Human DTXSID6025642 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025642 TK.Half.Life NA 3.383 hours 1compartment NA NA Rat Human -DTXSID6025642 Css NA 1.089 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025642 Css NA 4.906 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025642 Css NA 0.6617 mg/L PBTK NA 50% Rat Human -DTXSID6025642 Css NA 2.736 mg/L PBTK NA 95% Rat Human -DTXSID6025690 Clint NA 20.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025690 Fup NA 0.0856 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025690 Vd NA 2.835 L/kg 1compartment NA NA Human Human +DTXSID6025642 TK.Half.Life NA 0.5545 hours 1compartment NA NA Rat Human +DTXSID6025642 Css NA 0.03476 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025642 Css NA 0.217 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025642 Css NA 0.02164 mg/L PBTK NA 50% Rat Human +DTXSID6025642 Css NA 0.1285 mg/L PBTK NA 95% Rat Human +DTXSID6025690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025690 Fup 0.0128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025690 Vd NA 1.882 L/kg 1compartment NA NA Human Human DTXSID6025690 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6025690 TK.Half.Life NA 21.98 hours 1compartment NA NA Human Human -DTXSID6025690 Css NA 0.9247 mg/L 3compartmentss NA 50% Human Human -DTXSID6025690 Css NA 5.942 mg/L 3compartmentss NA 95% Human Human -DTXSID6025690 Css NA 0.6422 mg/L PBTK NA 50% Human Human -DTXSID6025690 Css NA 3.955 mg/L PBTK NA 95% Human Human -DTXSID6025690 Clint NA 20.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025690 Fup NA 0.0856 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025690 Vd NA 2.128 L/kg 1compartment NA NA Rat Human +DTXSID6025690 TK.Half.Life NA 24.94 hours 1compartment NA NA Human Human +DTXSID6025690 Css NA 2.042 mg/L 3compartmentss NA 50% Human Human +DTXSID6025690 Css NA 17.38 mg/L 3compartmentss NA 95% Human Human +DTXSID6025690 Css NA 1.293 mg/L PBTK NA 50% Human Human +DTXSID6025690 Css NA 10.66 mg/L PBTK NA 95% Human Human +DTXSID6025690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025690 Fup 0.0128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025690 Vd NA 1.393 L/kg 1compartment NA NA Rat Human DTXSID6025690 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6025690 TK.Half.Life NA 4.368 hours 1compartment NA NA Rat Human -DTXSID6025690 Css NA 0.5127 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025690 Css NA 2.599 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025690 Css NA 0.3392 mg/L PBTK NA 50% Rat Human -DTXSID6025690 Css NA 1.654 mg/L PBTK NA 95% Rat Human -DTXSID6025696 Clint NA 3.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025696 Fup NA 0.2787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025696 Vd NA 0.7865 L/kg 1compartment NA NA Human Human +DTXSID6025690 TK.Half.Life NA 8.367 hours 1compartment NA NA Rat Human +DTXSID6025690 Css NA 0.2662 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025690 Css NA 1.857 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025690 Css NA 0.1646 mg/L PBTK NA 50% Rat Human +DTXSID6025690 Css NA 1.093 mg/L PBTK NA 95% Rat Human +DTXSID6025696 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025696 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025696 Vd NA 0.868 L/kg 1compartment NA NA Human Human DTXSID6025696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025696 TK.Half.Life NA 3.455 hours 1compartment NA NA Human Human -DTXSID6025696 Css NA 0.4644 mg/L 3compartmentss NA 50% Human Human -DTXSID6025696 Css NA 2.479 mg/L 3compartmentss NA 95% Human Human -DTXSID6025696 Css NA 0.3337 mg/L PBTK NA 50% Human Human -DTXSID6025696 Css NA 1.609 mg/L PBTK NA 95% Human Human -DTXSID6025696 Clint NA 3.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025696 Fup NA 0.2787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025696 Vd NA 0.7015 L/kg 1compartment NA NA Rat Human +DTXSID6025696 TK.Half.Life NA 1.069 hours 1compartment NA NA Human Human +DTXSID6025696 Css NA 0.0602 mg/L 3compartmentss NA 50% Human Human +DTXSID6025696 Css NA 0.4711 mg/L 3compartmentss NA 95% Human Human +DTXSID6025696 Css NA 0.0447 mg/L PBTK NA 50% Human Human +DTXSID6025696 Css NA 0.3205 mg/L PBTK NA 95% Human Human +DTXSID6025696 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025696 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025696 Vd NA 0.7751 L/kg 1compartment NA NA Rat Human DTXSID6025696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025696 TK.Half.Life NA 1.694 hours 1compartment NA NA Rat Human -DTXSID6025696 Css NA 0.2168 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025696 Css NA 0.8882 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025696 Css NA 0.1497 mg/L PBTK NA 50% Rat Human -DTXSID6025696 Css NA 0.54 mg/L PBTK NA 95% Rat Human -DTXSID6025723 Clint NA 1.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025723 Fup NA 0.4823 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025723 Vd NA 1.004 L/kg 1compartment NA NA Human Human +DTXSID6025696 TK.Half.Life NA 0.4955 hours 1compartment NA NA Rat Human +DTXSID6025696 Css NA 0.007562 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025696 Css NA 0.04566 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025696 Css NA 0.005572 mg/L PBTK NA 50% Rat Human +DTXSID6025696 Css NA 0.03032 mg/L PBTK NA 95% Rat Human +DTXSID6025723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025723 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025723 Vd NA 0.6795 L/kg 1compartment NA NA Human Human DTXSID6025723 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025723 TK.Half.Life NA 4.542 hours 1compartment NA NA Human Human -DTXSID6025723 Css NA 0.4532 mg/L 3compartmentss NA 50% Human Human -DTXSID6025723 Css NA 2.704 mg/L 3compartmentss NA 95% Human Human -DTXSID6025723 Css NA 0.3633 mg/L PBTK NA 50% Human Human -DTXSID6025723 Css NA 1.79 mg/L PBTK NA 95% Human Human -DTXSID6025723 Clint NA 1.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025723 Fup NA 0.4823 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025723 Vd NA 0.9062 L/kg 1compartment NA NA Rat Human +DTXSID6025723 TK.Half.Life NA 1.004 hours 1compartment NA NA Human Human +DTXSID6025723 Css NA 0.0852 mg/L 3compartmentss NA 50% Human Human +DTXSID6025723 Css NA 0.6311 mg/L 3compartmentss NA 95% Human Human +DTXSID6025723 Css NA 0.05959 mg/L PBTK NA 50% Human Human +DTXSID6025723 Css NA 0.4147 mg/L PBTK NA 95% Human Human +DTXSID6025723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025723 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025723 Vd NA 0.6101 L/kg 1compartment NA NA Rat Human DTXSID6025723 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025723 TK.Half.Life NA 2.02 hours 1compartment NA NA Rat Human -DTXSID6025723 Css NA 0.1892 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025723 Css NA 0.9346 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025723 Css NA 0.1475 mg/L PBTK NA 50% Rat Human -DTXSID6025723 Css NA 0.5695 mg/L PBTK NA 95% Rat Human -DTXSID6025725 Clint NA 3.297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025725 Fup NA 0.5806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025725 Vd NA 1.231 L/kg 1compartment NA NA Human Human +DTXSID6025723 TK.Half.Life NA 0.4851 hours 1compartment NA NA Rat Human +DTXSID6025723 Css NA 0.01102 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025723 Css NA 0.05936 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025723 Css NA 0.007598 mg/L PBTK NA 50% Rat Human +DTXSID6025723 Css NA 0.0391 mg/L PBTK NA 95% Rat Human +DTXSID6025725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025725 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025725 Vd NA 0.7008 L/kg 1compartment NA NA Human Human DTXSID6025725 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025725 TK.Half.Life NA 2.825 hours 1compartment NA NA Human Human -DTXSID6025725 Css NA 0.2017 mg/L 3compartmentss NA 50% Human Human -DTXSID6025725 Css NA 1.664 mg/L 3compartmentss NA 95% Human Human -DTXSID6025725 Css NA 0.1709 mg/L PBTK NA 50% Human Human -DTXSID6025725 Css NA 1.106 mg/L PBTK NA 95% Human Human -DTXSID6025725 Clint NA 3.297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025725 Fup NA 0.5806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025725 Vd NA 1.098 L/kg 1compartment NA NA Rat Human +DTXSID6025725 TK.Half.Life NA 1.11 hours 1compartment NA NA Human Human +DTXSID6025725 Css NA 0.0983 mg/L 3compartmentss NA 50% Human Human +DTXSID6025725 Css NA 0.71 mg/L 3compartmentss NA 95% Human Human +DTXSID6025725 Css NA 0.06816 mg/L PBTK NA 50% Human Human +DTXSID6025725 Css NA 0.4609 mg/L PBTK NA 95% Human Human +DTXSID6025725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025725 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025725 Vd NA 0.6194 L/kg 1compartment NA NA Rat Human DTXSID6025725 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025725 TK.Half.Life NA 1.302 hours 1compartment NA NA Rat Human -DTXSID6025725 Css NA 0.09501 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025725 Css NA 0.6631 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025725 Css NA 0.07864 mg/L PBTK NA 50% Rat Human -DTXSID6025725 Css NA 0.4039 mg/L PBTK NA 95% Rat Human -DTXSID6025775 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025775 Fup NA 0.5836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025775 Vd NA 0.3589 L/kg 1compartment NA NA Human Human +DTXSID6025725 TK.Half.Life NA 0.5336 hours 1compartment NA NA Rat Human +DTXSID6025725 Css NA 0.01257 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025725 Css NA 0.06828 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025725 Css NA 0.008591 mg/L PBTK NA 50% Rat Human +DTXSID6025725 Css NA 0.04418 mg/L PBTK NA 95% Rat Human +DTXSID6025775 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025775 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025775 Vd NA 0.2441 L/kg 1compartment NA NA Human Human DTXSID6025775 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025775 TK.Half.Life NA 3.979 hours 1compartment NA NA Human Human -DTXSID6025775 Css NA 1.444 mg/L 3compartmentss NA 50% Human Human -DTXSID6025775 Css NA 8.928 mg/L 3compartmentss NA 95% Human Human -DTXSID6025775 Css NA 1.01 mg/L PBTK NA 50% Human Human -DTXSID6025775 Css NA 5.332 mg/L PBTK NA 95% Human Human -DTXSID6025775 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025775 Fup NA 0.5836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025775 Vd NA 0.3789 L/kg 1compartment NA NA Rat Human +DTXSID6025775 TK.Half.Life NA 8.924 hours 1compartment NA NA Human Human +DTXSID6025775 Css NA 4.696 mg/L 3compartmentss NA 50% Human Human +DTXSID6025775 Css NA 17.51 mg/L 3compartmentss NA 95% Human Human +DTXSID6025775 Css NA 2.921 mg/L PBTK NA 50% Human Human +DTXSID6025775 Css NA 10.55 mg/L PBTK NA 95% Human Human +DTXSID6025775 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025775 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025775 Vd NA 0.2492 L/kg 1compartment NA NA Rat Human DTXSID6025775 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025775 TK.Half.Life NA 1.431 hours 1compartment NA NA Rat Human -DTXSID6025775 Css NA 0.3884 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025775 Css NA 2.151 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025775 Css NA 0.2564 mg/L PBTK NA 50% Rat Human -DTXSID6025775 Css NA 1.216 mg/L PBTK NA 95% Rat Human -DTXSID6025850 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025850 Fup NA 0.9236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025850 Vd NA 1.264 L/kg 1compartment NA NA Human Human -DTXSID6025850 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025850 TK.Half.Life NA 9.363 hours 1compartment NA NA Human Human -DTXSID6025850 Css NA 0.84 mg/L 3compartmentss NA 50% Human Human -DTXSID6025850 Css NA 4.866 mg/L 3compartmentss NA 95% Human Human -DTXSID6025850 Css NA 0.768 mg/L PBTK NA 50% Human Human -DTXSID6025850 Css NA 3.308 mg/L PBTK NA 95% Human Human -DTXSID6025850 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025850 Fup NA 0.9236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025850 Vd NA 1.193 L/kg 1compartment NA NA Rat Human -DTXSID6025850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025850 TK.Half.Life NA 2.887 hours 1compartment NA NA Rat Human -DTXSID6025850 Css NA 0.2138 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025850 Css NA 1.318 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025850 Css NA 0.1918 mg/L PBTK NA 50% Rat Human -DTXSID6025850 Css NA 0.8217 mg/L PBTK NA 95% Rat Human -DTXSID6025939 Clint NA 24.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025939 Fup NA 0.0467 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025939 Vd NA 0.4478 L/kg 1compartment NA NA Human Human +DTXSID6025775 TK.Half.Life NA 3.104 hours 1compartment NA NA Rat Human +DTXSID6025775 Css NA 0.3128 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025775 Css NA 0.937 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025775 Css NA 0.1886 mg/L PBTK NA 50% Rat Human +DTXSID6025775 Css NA 0.5384 mg/L PBTK NA 95% Rat Human +DTXSID6025939 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025939 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025939 Vd NA 0.8033 L/kg 1compartment NA NA Human Human DTXSID6025939 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025939 TK.Half.Life NA 1.82 hours 1compartment NA NA Human Human -DTXSID6025939 Css NA 0.5821 mg/L 3compartmentss NA 50% Human Human -DTXSID6025939 Css NA 4.525 mg/L 3compartmentss NA 95% Human Human -DTXSID6025939 Css NA 0.3508 mg/L PBTK NA 50% Human Human -DTXSID6025939 Css NA 2.713 mg/L PBTK NA 95% Human Human -DTXSID6025939 Clint NA 24.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025939 Fup NA 0.0467 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025939 Vd NA 0.3719 L/kg 1compartment NA NA Rat Human +DTXSID6025939 TK.Half.Life NA 3.715 hours 1compartment NA NA Human Human +DTXSID6025939 Css NA 0.2961 mg/L 3compartmentss NA 50% Human Human +DTXSID6025939 Css NA 2.329 mg/L 3compartmentss NA 95% Human Human +DTXSID6025939 Css NA 0.1962 mg/L PBTK NA 50% Human Human +DTXSID6025939 Css NA 1.444 mg/L PBTK NA 95% Human Human +DTXSID6025939 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025939 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025939 Vd NA 0.6639 L/kg 1compartment NA NA Rat Human DTXSID6025939 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025939 TK.Half.Life NA 0.9337 hours 1compartment NA NA Rat Human -DTXSID6025939 Css NA 0.333 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025939 Css NA 1.978 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025939 Css NA 0.1879 mg/L PBTK NA 50% Rat Human -DTXSID6025939 Css NA 1.086 mg/L PBTK NA 95% Rat Human -DTXSID6025983 Clint NA 0.2767 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025983 Fup NA 0.8325 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6025983 Vd NA 1.117 L/kg 1compartment NA NA Human Human +DTXSID6025939 TK.Half.Life NA 1.765 hours 1compartment NA NA Rat Human +DTXSID6025939 Css NA 0.003023 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025939 Css NA 0.01953 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025939 Css NA 0.001908 mg/L PBTK NA 50% Rat Human +DTXSID6025939 Css NA 0.0113 mg/L PBTK NA 95% Rat Human +DTXSID6025983 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025983 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6025983 Vd NA 0.8788 L/kg 1compartment NA NA Human Human DTXSID6025983 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6025983 TK.Half.Life NA 6.239 hours 1compartment NA NA Human Human -DTXSID6025983 Css NA 0.619 mg/L 3compartmentss NA 50% Human Human -DTXSID6025983 Css NA 3.883 mg/L 3compartmentss NA 95% Human Human -DTXSID6025983 Css NA 0.5456 mg/L PBTK NA 50% Human Human -DTXSID6025983 Css NA 2.577 mg/L PBTK NA 95% Human Human -DTXSID6025983 Clint NA 0.2767 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025983 Fup NA 0.8325 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6025983 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID6025983 TK.Half.Life NA 0.8672 hours 1compartment NA NA Human Human +DTXSID6025983 Css NA 0.03778 mg/L 3compartmentss NA 50% Human Human +DTXSID6025983 Css NA 0.3607 mg/L 3compartmentss NA 95% Human Human +DTXSID6025983 Css NA 0.03008 mg/L PBTK NA 50% Human Human +DTXSID6025983 Css NA 0.2465 mg/L PBTK NA 95% Human Human +DTXSID6025983 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025983 Fup 0.5 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6025983 Vd NA 0.8212 L/kg 1compartment NA NA Rat Human DTXSID6025983 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6025983 TK.Half.Life NA 2.329 hours 1compartment NA NA Rat Human -DTXSID6025983 Css NA 0.19 mg/L 3compartmentss NA 50% Rat Human -DTXSID6025983 Css NA 1.178 mg/L 3compartmentss NA 95% Rat Human -DTXSID6025983 Css NA 0.1643 mg/L PBTK NA 50% Rat Human -DTXSID6025983 Css NA 0.7254 mg/L PBTK NA 95% Rat Human +DTXSID6025983 TK.Half.Life NA 0.4068 hours 1compartment NA NA Rat Human +DTXSID6025983 Css NA 0.004677 mg/L 3compartmentss NA 50% Rat Human +DTXSID6025983 Css NA 0.0351 mg/L 3compartmentss NA 95% Rat Human +DTXSID6025983 Css NA 0.003716 mg/L PBTK NA 50% Rat Human +DTXSID6025983 Css NA 0.02366 mg/L PBTK NA 95% Rat Human DTXSID6026080 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6026080 Fup NA 0.1585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6026080 Vd NA 0.4374 L/kg 1compartment NA NA Human Human DTXSID6026080 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID6026080 TK.Half.Life NA 17.86 hours 1compartment NA NA Human Human -DTXSID6026080 Css NA 5.474 mg/L 3compartmentss NA 50% Human Human -DTXSID6026080 Css NA 23.67 mg/L 3compartmentss NA 95% Human Human -DTXSID6026080 Css NA 3.67 mg/L PBTK NA 50% Human Human -DTXSID6026080 Css NA 14.35 mg/L PBTK NA 95% Human Human +DTXSID6026080 Css NA 5.274 mg/L 3compartmentss NA 50% Human Human +DTXSID6026080 Css NA 22.69 mg/L 3compartmentss NA 95% Human Human +DTXSID6026080 Css NA 3.528 mg/L PBTK NA 50% Human Human +DTXSID6026080 Css NA 13.65 mg/L PBTK NA 95% Human Human DTXSID6026080 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6026080 Fup NA 0.1585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6026080 Vd NA 0.4341 L/kg 1compartment NA NA Rat Human DTXSID6026080 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6026080 TK.Half.Life NA 6.038 hours 1compartment NA NA Rat Human -DTXSID6026080 Css NA 1.504 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026080 Css NA 5.488 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026080 Css NA 0.9508 mg/L PBTK NA 50% Rat Human -DTXSID6026080 Css NA 3.118 mg/L PBTK NA 95% Rat Human -DTXSID6026115 Clint NA 5.291 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026115 Fup NA 0.9418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026115 Vd NA 5.364 L/kg 1compartment NA NA Human Human +DTXSID6026080 Css NA 0.3376 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026080 Css NA 1.234 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026080 Css NA 0.2211 mg/L PBTK NA 50% Rat Human +DTXSID6026080 Css NA 0.7264 mg/L PBTK NA 95% Rat Human +DTXSID6026084 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6026084 Fup NA 0.054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6026084 Vd NA 0.8874 L/kg 1compartment NA NA Human Human +DTXSID6026084 Days.Css NA 25 Days PBTK NA NA Human Human +DTXSID6026084 TK.Half.Life NA 119.3 hours 1compartment NA NA Human Human +DTXSID6026084 Css NA 17.77 mg/L 3compartmentss NA 50% Human Human +DTXSID6026084 Css NA 85.12 mg/L 3compartmentss NA 95% Human Human +DTXSID6026084 Css NA 11.06 mg/L PBTK NA 50% Human Human +DTXSID6026084 Css NA 50.29 mg/L PBTK NA 95% Human Human +DTXSID6026084 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6026084 Fup NA 0.054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6026084 Vd NA 0.6849 L/kg 1compartment NA NA Rat Human +DTXSID6026084 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID6026084 TK.Half.Life NA 28.77 hours 1compartment NA NA Rat Human +DTXSID6026084 Css NA 0.3351 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026084 Css NA 2.201 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026084 Css NA 0.1996 mg/L PBTK NA 50% Rat Human +DTXSID6026084 Css NA 1.263 mg/L PBTK NA 95% Rat Human +DTXSID6026115 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026115 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026115 Vd NA 2.734 L/kg 1compartment NA NA Human Human DTXSID6026115 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6026115 TK.Half.Life NA 4.8 hours 1compartment NA NA Human Human -DTXSID6026115 Css NA 0.04682 mg/L 3compartmentss NA 50% Human Human -DTXSID6026115 Css NA 0.3119 mg/L 3compartmentss NA 95% Human Human -DTXSID6026115 Css NA 0.07356 mg/L PBTK NA 50% Human Human -DTXSID6026115 Css NA 0.3858 mg/L PBTK NA 95% Human Human -DTXSID6026115 Clint NA 5.291 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026115 Fup NA 0.9418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026115 Vd NA 5.485 L/kg 1compartment NA NA Rat Human +DTXSID6026115 TK.Half.Life NA 2.51 hours 1compartment NA NA Human Human +DTXSID6026115 Css NA 0.03531 mg/L 3compartmentss NA 50% Human Human +DTXSID6026115 Css NA 0.3117 mg/L 3compartmentss NA 95% Human Human +DTXSID6026115 Css NA 0.03764 mg/L PBTK NA 50% Human Human +DTXSID6026115 Css NA 0.2694 mg/L PBTK NA 95% Human Human +DTXSID6026115 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026115 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026115 Vd NA 2.758 L/kg 1compartment NA NA Rat Human DTXSID6026115 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026115 TK.Half.Life NA 2.767 hours 1compartment NA NA Rat Human -DTXSID6026115 Css NA 0.02091 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026115 Css NA 0.1143 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026115 Css NA 0.03474 mg/L PBTK NA 50% Rat Human -DTXSID6026115 Css NA 0.1288 mg/L PBTK NA 95% Rat Human -DTXSID6026161 Clint NA 0.1893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026161 Fup NA 0.1232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026161 Vd NA 0.3939 L/kg 1compartment NA NA Human Human -DTXSID6026161 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6026161 TK.Half.Life NA 15.77 hours 1compartment NA NA Human Human -DTXSID6026161 Css NA 5.652 mg/L 3compartmentss NA 50% Human Human -DTXSID6026161 Css NA 27.88 mg/L 3compartmentss NA 95% Human Human -DTXSID6026161 Css NA 3.689 mg/L PBTK NA 50% Human Human -DTXSID6026161 Css NA 16.85 mg/L PBTK NA 95% Human Human -DTXSID6026161 Clint NA 0.1893 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026161 Fup NA 0.1232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026161 Vd NA 0.3873 L/kg 1compartment NA NA Rat Human +DTXSID6026115 TK.Half.Life NA 1.38 hours 1compartment NA NA Rat Human +DTXSID6026115 Css NA 0.004218 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026115 Css NA 0.03025 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026115 Css NA 0.004708 mg/L PBTK NA 50% Rat Human +DTXSID6026115 Css NA 0.02538 mg/L PBTK NA 95% Rat Human +DTXSID6026161 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026161 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026161 Vd NA 0.3981 L/kg 1compartment NA NA Human Human +DTXSID6026161 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6026161 TK.Half.Life NA 0.8732 hours 1compartment NA NA Human Human +DTXSID6026161 Css NA 0.2107 mg/L 3compartmentss NA 50% Human Human +DTXSID6026161 Css NA 1.787 mg/L 3compartmentss NA 95% Human Human +DTXSID6026161 Css NA 0.1372 mg/L PBTK NA 50% Human Human +DTXSID6026161 Css NA 1.129 mg/L PBTK NA 95% Human Human +DTXSID6026161 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026161 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026161 Vd NA 0.3916 L/kg 1compartment NA NA Rat Human DTXSID6026161 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026161 TK.Half.Life NA 6.017 hours 1compartment NA NA Rat Human -DTXSID6026161 Css NA 1.876 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026161 Css NA 7.817 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026161 Css NA 1.151 mg/L PBTK NA 50% Rat Human -DTXSID6026161 Css NA 4.366 mg/L PBTK NA 95% Rat Human -DTXSID6026292 Clint NA 3.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026292 Fup NA 0.2171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026292 Vd NA 2.699 L/kg 1compartment NA NA Human Human -DTXSID6026292 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6026292 TK.Half.Life NA 36.83 hours 1compartment NA NA Human Human -DTXSID6026292 Css NA 1.568 mg/L 3compartmentss NA 50% Human Human -DTXSID6026292 Css NA 7.302 mg/L 3compartmentss NA 95% Human Human -DTXSID6026292 Css NA 1.142 mg/L PBTK NA 50% Human Human -DTXSID6026292 Css NA 5.006 mg/L PBTK NA 95% Human Human -DTXSID6026292 Clint NA 3.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026292 Fup NA 0.2171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026292 Vd NA 2.05 L/kg 1compartment NA NA Rat Human -DTXSID6026292 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6026292 TK.Half.Life NA 7.635 hours 1compartment NA NA Rat Human -DTXSID6026292 Css NA 0.776 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026292 Css NA 2.544 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026292 Css NA 0.5415 mg/L PBTK NA 50% Rat Human -DTXSID6026292 Css NA 1.641 mg/L PBTK NA 95% Rat Human -DTXSID6026294 Clint NA 182.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026294 Fup NA 0.0068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026294 Vd NA 198.9 L/kg 1compartment NA NA Human Human -DTXSID6026294 Days.Css NA 161 Days PBTK NA NA Human Human -DTXSID6026294 TK.Half.Life NA 705.9 hours 1compartment NA NA Human Human -DTXSID6026294 Css NA 0.01114 mg/L 3compartmentss NA 50% Human Human -DTXSID6026294 Css NA 0.06558 mg/L 3compartmentss NA 95% Human Human -DTXSID6026294 Css NA 0.2931 mg/L PBTK NA 50% Human Human -DTXSID6026294 Css NA 1.594 mg/L PBTK NA 95% Human Human -DTXSID6026294 Clint NA 182.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026294 Fup NA 0.0068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026294 Vd NA 175.6 L/kg 1compartment NA NA Rat Human -DTXSID6026294 Days.Css NA 110 Days PBTK NA NA Rat Human -DTXSID6026294 TK.Half.Life NA 111.9 hours 1compartment NA NA Rat Human -DTXSID6026294 Css NA 0.005664 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026294 Css NA 0.02476 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026294 Css NA 0.1592 mg/L PBTK NA 50% Rat Human -DTXSID6026294 Css NA 0.6928 mg/L PBTK NA 95% Rat Human -DTXSID6026325 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026325 Fup NA 0.5544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026325 Vd NA 0.9806 L/kg 1compartment NA NA Human Human +DTXSID6026161 TK.Half.Life NA 0.5016 hours 1compartment NA NA Rat Human +DTXSID6026161 Css NA 0.02732 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026161 Css NA 0.1766 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026161 Css NA 0.01738 mg/L PBTK NA 50% Rat Human +DTXSID6026161 Css NA 0.1056 mg/L PBTK NA 95% Rat Human +DTXSID6026167 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026167 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026167 Vd NA 1.021 L/kg 1compartment NA NA Human Human +DTXSID6026167 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6026167 TK.Half.Life NA 1.463 hours 1compartment NA NA Human Human +DTXSID6026167 Css NA 0.08244 mg/L 3compartmentss NA 50% Human Human +DTXSID6026167 Css NA 0.589 mg/L 3compartmentss NA 95% Human Human +DTXSID6026167 Css NA 0.05981 mg/L PBTK NA 50% Human Human +DTXSID6026167 Css NA 0.395 mg/L PBTK NA 95% Human Human +DTXSID6026167 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026167 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026167 Vd NA 0.8603 L/kg 1compartment NA NA Rat Human +DTXSID6026167 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6026167 TK.Half.Life NA 0.6442 hours 1compartment NA NA Rat Human +DTXSID6026167 Css NA 0.01046 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026167 Css NA 0.05703 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026167 Css NA 0.007496 mg/L PBTK NA 50% Rat Human +DTXSID6026167 Css NA 0.03803 mg/L PBTK NA 95% Rat Human +DTXSID6026169 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026169 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026169 Vd NA 1.079 L/kg 1compartment NA NA Human Human +DTXSID6026169 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6026169 TK.Half.Life NA 1.436 hours 1compartment NA NA Human Human +DTXSID6026169 Css NA 0.07089 mg/L 3compartmentss NA 50% Human Human +DTXSID6026169 Css NA 0.5452 mg/L 3compartmentss NA 95% Human Human +DTXSID6026169 Css NA 0.05193 mg/L PBTK NA 50% Human Human +DTXSID6026169 Css NA 0.3697 mg/L PBTK NA 95% Human Human +DTXSID6026169 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026169 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026169 Vd NA 0.913 L/kg 1compartment NA NA Rat Human +DTXSID6026169 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6026169 TK.Half.Life NA 0.6267 hours 1compartment NA NA Rat Human +DTXSID6026169 Css NA 0.00882 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026169 Css NA 0.05313 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026169 Css NA 0.006531 mg/L PBTK NA 50% Rat Human +DTXSID6026169 Css NA 0.03569 mg/L PBTK NA 95% Rat Human +DTXSID6026240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026240 Fup 0.0127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026240 Vd NA 2.341 L/kg 1compartment NA NA Human Human +DTXSID6026240 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID6026240 TK.Half.Life NA 34.78 hours 1compartment NA NA Human Human +DTXSID6026240 Css NA 2.154 mg/L 3compartmentss NA 50% Human Human +DTXSID6026240 Css NA 16.77 mg/L 3compartmentss NA 95% Human Human +DTXSID6026240 Css NA 1.404 mg/L PBTK NA 50% Human Human +DTXSID6026240 Css NA 10.5 mg/L PBTK NA 95% Human Human +DTXSID6026240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026240 Fup 0.0127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026240 Vd NA 1.742 L/kg 1compartment NA NA Rat Human +DTXSID6026240 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6026240 TK.Half.Life NA 9.411 hours 1compartment NA NA Rat Human +DTXSID6026240 Css NA 0.2792 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026240 Css NA 1.831 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026240 Css NA 0.1792 mg/L PBTK NA 50% Rat Human +DTXSID6026240 Css NA 1.134 mg/L PBTK NA 95% Rat Human +DTXSID6026294 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026294 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026294 Vd NA 361.6 L/kg 1compartment NA NA Human Human +DTXSID6026294 Days.Css NA 2870 Days PBTK NA NA Human Human +DTXSID6026294 TK.Half.Life NA 10560 hours 1compartment NA NA Human Human +DTXSID6026294 Css NA 0.02462 mg/L 3compartmentss NA 50% Human Human +DTXSID6026294 Css NA 0.1634 mg/L 3compartmentss NA 95% Human Human +DTXSID6026294 Css NA 1.308 mg/L PBTK NA 50% Human Human +DTXSID6026294 Css NA 7.913 mg/L PBTK NA 95% Human Human +DTXSID6026294 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026294 Fup 0.0559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026294 Vd NA 324.4 L/kg 1compartment NA NA Rat Human +DTXSID6026294 Days.Css NA 1832 Days PBTK NA NA Rat Human +DTXSID6026294 TK.Half.Life NA 1598 hours 1compartment NA NA Rat Human +DTXSID6026294 Css NA 0.0002394 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026294 Css NA 0.001516 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026294 Css NA 0.01344 mg/L PBTK NA 50% Rat Human +DTXSID6026294 Css NA 0.08358 mg/L PBTK NA 95% Rat Human +DTXSID6026325 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026325 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026325 Vd NA 0.9108 L/kg 1compartment NA NA Human Human DTXSID6026325 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6026325 TK.Half.Life NA 1.222 hours 1compartment NA NA Human Human -DTXSID6026325 Css NA 0.07814 mg/L 3compartmentss NA 50% Human Human -DTXSID6026325 Css NA 0.6909 mg/L 3compartmentss NA 95% Human Human -DTXSID6026325 Css NA 0.06412 mg/L PBTK NA 50% Human Human -DTXSID6026325 Css NA 0.4704 mg/L PBTK NA 95% Human Human -DTXSID6026325 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026325 Fup NA 0.5544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026325 Vd NA 0.9109 L/kg 1compartment NA NA Rat Human +DTXSID6026325 TK.Half.Life NA 0.9061 hours 1compartment NA NA Human Human +DTXSID6026325 Css NA 0.03964 mg/L 3compartmentss NA 50% Human Human +DTXSID6026325 Css NA 0.3415 mg/L 3compartmentss NA 95% Human Human +DTXSID6026325 Css NA 0.03123 mg/L PBTK NA 50% Human Human +DTXSID6026325 Css NA 0.2384 mg/L PBTK NA 95% Human Human +DTXSID6026325 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026325 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026325 Vd NA 0.8455 L/kg 1compartment NA NA Rat Human DTXSID6026325 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026325 TK.Half.Life NA 0.596 hours 1compartment NA NA Rat Human -DTXSID6026325 Css NA 0.0398 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026325 Css NA 0.3026 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026325 Css NA 0.03163 mg/L PBTK NA 50% Rat Human -DTXSID6026325 Css NA 0.1903 mg/L PBTK NA 95% Rat Human +DTXSID6026325 TK.Half.Life NA 0.4232 hours 1compartment NA NA Rat Human +DTXSID6026325 Css NA 0.004774 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026325 Css NA 0.03449 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026325 Css NA 0.003832 mg/L PBTK NA 50% Rat Human +DTXSID6026325 Css NA 0.02387 mg/L PBTK NA 95% Rat Human DTXSID6026373 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6026373 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026373 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID6026373 Vd NA 0.3278 L/kg 1compartment NA NA Human Human DTXSID6026373 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6026373 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID6026373 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID6026373 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID6026373 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID6026373 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID6026373 TK.Half.Life NA 6.564 hours 1compartment NA NA Human Human +DTXSID6026373 Css NA 2.057 mg/L 3compartmentss NA 50% Human Human +DTXSID6026373 Css NA 8.591 mg/L 3compartmentss NA 95% Human Human +DTXSID6026373 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID6026373 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID6026373 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6026373 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026373 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID6026373 Vd NA 0.3456 L/kg 1compartment NA NA Rat Human DTXSID6026373 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026373 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID6026373 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026373 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026373 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID6026373 Css NA 1.313 mg/L PBTK NA 95% Rat Human -DTXSID6026450 Clint NA 116.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026450 Fup NA 0.1481 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026450 Vd NA 0.6377 L/kg 1compartment NA NA Human Human -DTXSID6026450 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6026450 TK.Half.Life NA 0.6776 hours 1compartment NA NA Human Human -DTXSID6026450 Css NA 0.03389 mg/L 3compartmentss NA 50% Human Human -DTXSID6026450 Css NA 0.2991 mg/L 3compartmentss NA 95% Human Human -DTXSID6026450 Css NA 0.02211 mg/L PBTK NA 50% Human Human -DTXSID6026450 Css NA 0.1834 mg/L PBTK NA 95% Human Human -DTXSID6026450 Clint NA 116.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026450 Fup NA 0.1481 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026450 Vd NA 0.5516 L/kg 1compartment NA NA Rat Human -DTXSID6026450 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026450 TK.Half.Life NA 0.2838 hours 1compartment NA NA Rat Human -DTXSID6026450 Css NA 0.01985 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026450 Css NA 0.1328 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026450 Css NA 0.01218 mg/L PBTK NA 50% Rat Human -DTXSID6026450 Css NA 0.07918 mg/L PBTK NA 95% Rat Human +DTXSID6026373 TK.Half.Life NA 2.358 hours 1compartment NA NA Rat Human +DTXSID6026373 Css NA 0.03855 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026373 Css NA 0.2273 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026373 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID6026373 Css NA 0.1369 mg/L PBTK NA 95% Rat Human DTXSID6026535 Clint NA 0.09729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6026535 Fup NA 0.296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026535 Vd NA 0.4013 L/kg 1compartment NA NA Human Human +DTXSID6026535 Vd NA 0.4201 L/kg 1compartment NA NA Human Human DTXSID6026535 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6026535 TK.Half.Life NA 7.361 hours 1compartment NA NA Human Human -DTXSID6026535 Css NA 2.14 mg/L 3compartmentss NA 50% Human Human -DTXSID6026535 Css NA 8.639 mg/L 3compartmentss NA 95% Human Human -DTXSID6026535 Css NA 1.461 mg/L PBTK NA 50% Human Human -DTXSID6026535 Css NA 5.328 mg/L PBTK NA 95% Human Human +DTXSID6026535 TK.Half.Life NA 7.794 hours 1compartment NA NA Human Human +DTXSID6026535 Css NA 1.835 mg/L 3compartmentss NA 50% Human Human +DTXSID6026535 Css NA 7.419 mg/L 3compartmentss NA 95% Human Human +DTXSID6026535 Css NA 1.261 mg/L PBTK NA 50% Human Human +DTXSID6026535 Css NA 4.571 mg/L PBTK NA 95% Human Human DTXSID6026535 Clint NA 0.09729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6026535 Fup NA 0.296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026535 Vd NA 0.4171 L/kg 1compartment NA NA Rat Human +DTXSID6026535 Vd NA 0.4336 L/kg 1compartment NA NA Rat Human DTXSID6026535 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026535 TK.Half.Life NA 2.843 hours 1compartment NA NA Rat Human -DTXSID6026535 Css NA 0.6642 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026535 Css NA 2.183 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026535 Css NA 0.4312 mg/L PBTK NA 50% Rat Human -DTXSID6026535 Css NA 1.26 mg/L PBTK NA 95% Rat Human -DTXSID6026537 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026537 Fup NA 0.781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026537 Vd NA 0.412 L/kg 1compartment NA NA Human Human +DTXSID6026535 TK.Half.Life NA 2.972 hours 1compartment NA NA Rat Human +DTXSID6026535 Css NA 0.03708 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026535 Css NA 0.2234 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026535 Css NA 0.02441 mg/L PBTK NA 50% Rat Human +DTXSID6026535 Css NA 0.1368 mg/L PBTK NA 95% Rat Human +DTXSID6026537 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026537 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026537 Vd NA 0.4189 L/kg 1compartment NA NA Human Human DTXSID6026537 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6026537 TK.Half.Life NA 3.413 hours 1compartment NA NA Human Human -DTXSID6026537 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID6026537 Css NA 6.477 mg/L 3compartmentss NA 95% Human Human -DTXSID6026537 Css NA 0.8255 mg/L PBTK NA 50% Human Human -DTXSID6026537 Css NA 3.964 mg/L PBTK NA 95% Human Human -DTXSID6026537 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026537 Fup NA 0.781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026537 Vd NA 0.4371 L/kg 1compartment NA NA Rat Human +DTXSID6026537 TK.Half.Life NA 3.358 hours 1compartment NA NA Human Human +DTXSID6026537 Css NA 0.9714 mg/L 3compartmentss NA 50% Human Human +DTXSID6026537 Css NA 5.255 mg/L 3compartmentss NA 95% Human Human +DTXSID6026537 Css NA 0.703 mg/L PBTK NA 50% Human Human +DTXSID6026537 Css NA 3.257 mg/L PBTK NA 95% Human Human +DTXSID6026537 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026537 Fup 0.807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026537 Vd NA 0.4446 L/kg 1compartment NA NA Rat Human DTXSID6026537 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026537 TK.Half.Life NA 1.234 hours 1compartment NA NA Rat Human -DTXSID6026537 Css NA 0.298 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026537 Css NA 1.658 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026537 Css NA 0.2056 mg/L PBTK NA 50% Rat Human -DTXSID6026537 Css NA 0.9495 mg/L PBTK NA 95% Rat Human +DTXSID6026537 TK.Half.Life NA 1.215 hours 1compartment NA NA Rat Human +DTXSID6026537 Css NA 0.02475 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026537 Css NA 0.1581 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026537 Css NA 0.01722 mg/L PBTK NA 50% Rat Human +DTXSID6026537 Css NA 0.09647 mg/L PBTK NA 95% Rat Human DTXSID6026799 Clint NA 0.3769 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6026799 Fup NA 0.3087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026799 Vd NA 0.9272 L/kg 1compartment NA NA Human Human +DTXSID6026799 Vd NA 1.051 L/kg 1compartment NA NA Human Human DTXSID6026799 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6026799 TK.Half.Life NA 12.71 hours 1compartment NA NA Human Human -DTXSID6026799 Css NA 1.49 mg/L 3compartmentss NA 50% Human Human -DTXSID6026799 Css NA 6.029 mg/L 3compartmentss NA 95% Human Human -DTXSID6026799 Css NA 1.109 mg/L PBTK NA 50% Human Human -DTXSID6026799 Css NA 3.902 mg/L PBTK NA 95% Human Human +DTXSID6026799 TK.Half.Life NA 14.79 hours 1compartment NA NA Human Human +DTXSID6026799 Css NA 1.286 mg/L 3compartmentss NA 50% Human Human +DTXSID6026799 Css NA 5.159 mg/L 3compartmentss NA 95% Human Human +DTXSID6026799 Css NA 0.9654 mg/L PBTK NA 50% Human Human +DTXSID6026799 Css NA 3.326 mg/L PBTK NA 95% Human Human DTXSID6026799 Clint NA 0.3769 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6026799 Fup NA 0.3087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026799 Vd NA 0.8101 L/kg 1compartment NA NA Rat Human +DTXSID6026799 Vd NA 0.8977 L/kg 1compartment NA NA Rat Human DTXSID6026799 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026799 TK.Half.Life NA 4.489 hours 1compartment NA NA Rat Human -DTXSID6026799 Css NA 0.5138 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026799 Css NA 1.819 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026799 Css NA 0.3658 mg/L PBTK NA 50% Rat Human -DTXSID6026799 Css NA 1.085 mg/L PBTK NA 95% Rat Human +DTXSID6026799 TK.Half.Life NA 5.001 hours 1compartment NA NA Rat Human +DTXSID6026799 Css NA 0.02938 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026799 Css NA 0.1792 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026799 Css NA 0.0214 mg/L PBTK NA 50% Rat Human +DTXSID6026799 Css NA 0.1174 mg/L PBTK NA 95% Rat Human DTXSID6026878 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6026878 Fup NA 0.9492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6026878 Vd NA 0.8059 L/kg 1compartment NA NA Human Human DTXSID6026878 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6026878 TK.Half.Life NA 1.048 hours 1compartment NA NA Human Human -DTXSID6026878 Css NA 0.1198 mg/L 3compartmentss NA 50% Human Human -DTXSID6026878 Css NA 0.8473 mg/L 3compartmentss NA 95% Human Human -DTXSID6026878 Css NA 0.09927 mg/L PBTK NA 50% Human Human -DTXSID6026878 Css NA 0.5974 mg/L PBTK NA 95% Human Human +DTXSID6026878 Css NA 0.09846 mg/L 3compartmentss NA 50% Human Human +DTXSID6026878 Css NA 0.7543 mg/L 3compartmentss NA 95% Human Human +DTXSID6026878 Css NA 0.0816 mg/L PBTK NA 50% Human Human +DTXSID6026878 Css NA 0.5103 mg/L PBTK NA 95% Human Human DTXSID6026878 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6026878 Fup NA 0.9492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6026878 Vd NA 0.8351 L/kg 1compartment NA NA Rat Human DTXSID6026878 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6026878 TK.Half.Life NA 0.5705 hours 1compartment NA NA Rat Human -DTXSID6026878 Css NA 0.05431 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026878 Css NA 0.3462 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026878 Css NA 0.04456 mg/L PBTK NA 50% Rat Human -DTXSID6026878 Css NA 0.2175 mg/L PBTK NA 95% Rat Human -DTXSID6026901 Clint NA 69.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026901 Fup NA 0.4073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026901 Vd NA 4.105 L/kg 1compartment NA NA Human Human -DTXSID6026901 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6026901 TK.Half.Life NA 3.529 hours 1compartment NA NA Human Human -DTXSID6026901 Css NA 0.02305 mg/L 3compartmentss NA 50% Human Human -DTXSID6026901 Css NA 0.1503 mg/L 3compartmentss NA 95% Human Human -DTXSID6026901 Css NA 0.02059 mg/L PBTK NA 50% Human Human -DTXSID6026901 Css NA 0.1247 mg/L PBTK NA 95% Human Human -DTXSID6026901 Clint NA 69.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026901 Fup NA 0.4073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026901 Vd NA 3.455 L/kg 1compartment NA NA Rat Human -DTXSID6026901 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026901 TK.Half.Life NA 1.093 hours 1compartment NA NA Rat Human -DTXSID6026901 Css NA 0.01269 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026901 Css NA 0.06891 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026901 Css NA 0.01114 mg/L PBTK NA 50% Rat Human -DTXSID6026901 Css NA 0.05768 mg/L PBTK NA 95% Rat Human -DTXSID6026955 Clint NA 0.06432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026955 Fup NA 0.5032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6026955 Vd NA 0.4319 L/kg 1compartment NA NA Human Human -DTXSID6026955 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6026955 TK.Half.Life NA 4.99 hours 1compartment NA NA Human Human -DTXSID6026955 Css NA 1.346 mg/L 3compartmentss NA 50% Human Human -DTXSID6026955 Css NA 6.802 mg/L 3compartmentss NA 95% Human Human -DTXSID6026955 Css NA 0.9702 mg/L PBTK NA 50% Human Human -DTXSID6026955 Css NA 4.23 mg/L PBTK NA 95% Human Human -DTXSID6026955 Clint NA 0.06432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026955 Fup NA 0.5032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6026955 Vd NA 0.4452 L/kg 1compartment NA NA Rat Human +DTXSID6026878 Css NA 0.003226 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026878 Css NA 0.02968 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026878 Css NA 0.002618 mg/L PBTK NA 50% Rat Human +DTXSID6026878 Css NA 0.02034 mg/L PBTK NA 95% Rat Human +DTXSID6026905 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026905 Fup 0.734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026905 Vd NA 0.8014 L/kg 1compartment NA NA Human Human +DTXSID6026905 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6026905 TK.Half.Life NA 7.11 hours 1compartment NA NA Human Human +DTXSID6026905 Css NA 1.004 mg/L 3compartmentss NA 50% Human Human +DTXSID6026905 Css NA 6.248 mg/L 3compartmentss NA 95% Human Human +DTXSID6026905 Css NA 0.8392 mg/L PBTK NA 50% Human Human +DTXSID6026905 Css NA 4.069 mg/L PBTK NA 95% Human Human +DTXSID6026905 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026905 Fup 0.734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026905 Vd NA 0.8069 L/kg 1compartment NA NA Rat Human +DTXSID6026905 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6026905 TK.Half.Life NA 2.428 hours 1compartment NA NA Rat Human +DTXSID6026905 Css NA 0.05977 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026905 Css NA 0.3779 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026905 Css NA 0.04988 mg/L PBTK NA 50% Rat Human +DTXSID6026905 Css NA 0.2338 mg/L PBTK NA 95% Rat Human +DTXSID6026955 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026955 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6026955 Vd NA 0.7306 L/kg 1compartment NA NA Human Human +DTXSID6026955 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6026955 TK.Half.Life NA 13.06 hours 1compartment NA NA Human Human +DTXSID6026955 Css NA 1.929 mg/L 3compartmentss NA 50% Human Human +DTXSID6026955 Css NA 8.174 mg/L 3compartmentss NA 95% Human Human +DTXSID6026955 Css NA 1.436 mg/L PBTK NA 50% Human Human +DTXSID6026955 Css NA 5.215 mg/L PBTK NA 95% Human Human +DTXSID6026955 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026955 Fup 0.371 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6026955 Vd NA 0.6789 L/kg 1compartment NA NA Rat Human DTXSID6026955 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6026955 TK.Half.Life NA 1.85 hours 1compartment NA NA Rat Human -DTXSID6026955 Css NA 0.3932 mg/L 3compartmentss NA 50% Rat Human -DTXSID6026955 Css NA 1.797 mg/L 3compartmentss NA 95% Rat Human -DTXSID6026955 Css NA 0.2711 mg/L PBTK NA 50% Rat Human -DTXSID6026955 Css NA 1.042 mg/L PBTK NA 95% Rat Human +DTXSID6026955 TK.Half.Life NA 4.061 hours 1compartment NA NA Rat Human +DTXSID6026955 Css NA 0.1222 mg/L 3compartmentss NA 50% Rat Human +DTXSID6026955 Css NA 0.4379 mg/L 3compartmentss NA 95% Rat Human +DTXSID6026955 Css NA 0.09002 mg/L PBTK NA 50% Rat Human +DTXSID6026955 Css NA 0.2708 mg/L PBTK NA 95% Rat Human DTXSID6027050 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6027050 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027050 Vd NA 0.4732 L/kg 1compartment NA NA Human Human +DTXSID6027050 Vd NA 0.3414 L/kg 1compartment NA NA Human Human DTXSID6027050 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027050 TK.Half.Life NA 5.986 hours 1compartment NA NA Human Human -DTXSID6027050 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human -DTXSID6027050 Css NA 7.282 mg/L 3compartmentss NA 95% Human Human -DTXSID6027050 Css NA 1.074 mg/L PBTK NA 50% Human Human -DTXSID6027050 Css NA 4.538 mg/L PBTK NA 95% Human Human +DTXSID6027050 TK.Half.Life NA 4.121 hours 1compartment NA NA Human Human +DTXSID6027050 Css NA 1.239 mg/L 3compartmentss NA 50% Human Human +DTXSID6027050 Css NA 6.118 mg/L 3compartmentss NA 95% Human Human +DTXSID6027050 Css NA 0.8586 mg/L PBTK NA 50% Human Human +DTXSID6027050 Css NA 3.749 mg/L PBTK NA 95% Human Human DTXSID6027050 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6027050 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027050 Vd NA 0.4747 L/kg 1compartment NA NA Rat Human +DTXSID6027050 Vd NA 0.362 L/kg 1compartment NA NA Rat Human DTXSID6027050 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027050 TK.Half.Life NA 2.095 hours 1compartment NA NA Rat Human -DTXSID6027050 Css NA 0.4147 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027050 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027050 Css NA 0.285 mg/L PBTK NA 50% Rat Human -DTXSID6027050 Css NA 1.07 mg/L PBTK NA 95% Rat Human -DTXSID6027052 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID6027052 Fup 0.01953 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID6027052 Vd NA 2.98 L/kg 1compartment NA NA Human Human -DTXSID6027052 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6027052 TK.Half.Life NA 12700 hours 1compartment NA NA Human Human -DTXSID6027052 Css NA 517.4 mg/L 3compartmentss NA 50% Human Human -DTXSID6027052 Css NA 1498 mg/L 3compartmentss NA 95% Human Human -DTXSID6027052 Css NA 354.8 mg/L PBTK NA 50% Human Human -DTXSID6027052 Css NA 962 mg/L PBTK NA 95% Human Human -DTXSID6027052 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID6027052 Fup 0.01953 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID6027052 Vd NA 2.232 L/kg 1compartment NA NA Rat Human -DTXSID6027052 Days.Css NA 885 Days PBTK NA NA Rat Human -DTXSID6027052 TK.Half.Life NA 964.6 hours 1compartment NA NA Rat Human -DTXSID6027052 Css NA 140.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027052 Css NA 331.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027052 Css NA 92.23 mg/L PBTK NA 50% Rat Human -DTXSID6027052 Css NA 196.8 mg/L PBTK NA 95% Rat Human +DTXSID6027050 TK.Half.Life NA 1.56 hours 1compartment NA NA Rat Human +DTXSID6027050 Css NA 0.0245 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027050 Css NA 0.1678 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027050 Css NA 0.0164 mg/L PBTK NA 50% Rat Human +DTXSID6027050 Css NA 0.1014 mg/L PBTK NA 95% Rat Human DTXSID6027131 Clint NA 0.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6027131 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027131 Vd NA 0.8377 L/kg 1compartment NA NA Human Human +DTXSID6027131 Vd NA 0.8391 L/kg 1compartment NA NA Human Human DTXSID6027131 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027131 TK.Half.Life NA 2.276 hours 1compartment NA NA Human Human -DTXSID6027131 Css NA 0.3204 mg/L 3compartmentss NA 50% Human Human -DTXSID6027131 Css NA 2.342 mg/L 3compartmentss NA 95% Human Human -DTXSID6027131 Css NA 0.2726 mg/L PBTK NA 50% Human Human -DTXSID6027131 Css NA 1.521 mg/L PBTK NA 95% Human Human +DTXSID6027131 TK.Half.Life NA 2.28 hours 1compartment NA NA Human Human +DTXSID6027131 Css NA 0.2684 mg/L 3compartmentss NA 50% Human Human +DTXSID6027131 Css NA 1.779 mg/L 3compartmentss NA 95% Human Human +DTXSID6027131 Css NA 0.2282 mg/L PBTK NA 50% Human Human +DTXSID6027131 Css NA 1.229 mg/L PBTK NA 95% Human Human DTXSID6027131 Clint NA 0.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6027131 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027131 Vd NA 0.8667 L/kg 1compartment NA NA Rat Human +DTXSID6027131 Vd NA 0.8684 L/kg 1compartment NA NA Rat Human DTXSID6027131 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027131 TK.Half.Life NA 1.121 hours 1compartment NA NA Rat Human -DTXSID6027131 Css NA 0.1178 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027131 Css NA 0.7471 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027131 Css NA 0.09908 mg/L PBTK NA 50% Rat Human -DTXSID6027131 Css NA 0.4565 mg/L PBTK NA 95% Rat Human -DTXSID6027133 Clint NA 22.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027133 Fup NA 0.2507 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027133 Vd NA 0.687 L/kg 1compartment NA NA Human Human +DTXSID6027131 TK.Half.Life NA 1.123 hours 1compartment NA NA Rat Human +DTXSID6027131 Css NA 0.006856 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027131 Css NA 0.0568 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027131 Css NA 0.005735 mg/L PBTK NA 50% Rat Human +DTXSID6027131 Css NA 0.03956 mg/L PBTK NA 95% Rat Human +DTXSID6027133 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027133 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027133 Vd NA 0.4751 L/kg 1compartment NA NA Human Human DTXSID6027133 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027133 TK.Half.Life NA 0.97 hours 1compartment NA NA Human Human -DTXSID6027133 Css NA 0.08326 mg/L 3compartmentss NA 50% Human Human -DTXSID6027133 Css NA 0.5852 mg/L 3compartmentss NA 95% Human Human -DTXSID6027133 Css NA 0.05848 mg/L PBTK NA 50% Human Human -DTXSID6027133 Css NA 0.3854 mg/L PBTK NA 95% Human Human -DTXSID6027133 Clint NA 22.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027133 Fup NA 0.2507 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027133 Vd NA 0.6194 L/kg 1compartment NA NA Rat Human +DTXSID6027133 TK.Half.Life NA 7.593 hours 1compartment NA NA Human Human +DTXSID6027133 Css NA 1.562 mg/L 3compartmentss NA 50% Human Human +DTXSID6027133 Css NA 6.706 mg/L 3compartmentss NA 95% Human Human +DTXSID6027133 Css NA 1.127 mg/L PBTK NA 50% Human Human +DTXSID6027133 Css NA 4.193 mg/L PBTK NA 95% Human Human +DTXSID6027133 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027133 Fup 0.405 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027133 Vd NA 0.4917 L/kg 1compartment NA NA Rat Human DTXSID6027133 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027133 TK.Half.Life NA 0.4668 hours 1compartment NA NA Rat Human -DTXSID6027133 Css NA 0.04522 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027133 Css NA 0.2507 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027133 Css NA 0.03033 mg/L PBTK NA 50% Rat Human -DTXSID6027133 Css NA 0.1562 mg/L PBTK NA 95% Rat Human -DTXSID6027137 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027137 Fup NA 0.023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027137 Vd NA 22.88 L/kg 1compartment NA NA Human Human -DTXSID6027137 Days.Css NA 11150 Days PBTK NA NA Human Human -DTXSID6027137 TK.Half.Life NA 1080000 hours 1compartment NA NA Human Human -DTXSID6027137 Css NA 1506 mg/L 3compartmentss NA 50% Human Human -DTXSID6027137 Css NA 3788 mg/L 3compartmentss NA 95% Human Human -DTXSID6027137 Css NA 3635 mg/L PBTK NA 50% Human Human -DTXSID6027137 Css NA 7831 mg/L PBTK NA 95% Human Human -DTXSID6027137 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027137 Fup NA 0.023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027137 Vd NA 18.68 L/kg 1compartment NA NA Rat Human -DTXSID6027137 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID6027137 TK.Half.Life NA 73030 hours 1compartment NA NA Rat Human -DTXSID6027137 Css NA 378.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027137 Css NA 653.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027137 Css NA 971.7 mg/L PBTK NA 50% Rat Human -DTXSID6027137 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID6027133 TK.Half.Life NA 2.677 hours 1compartment NA NA Rat Human +DTXSID6027133 Css NA 0.02819 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027133 Css NA 0.1794 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027133 Css NA 0.01947 mg/L PBTK NA 50% Rat Human +DTXSID6027133 Css NA 0.1124 mg/L PBTK NA 95% Rat Human +DTXSID6027137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027137 Fup 0.0132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027137 Vd NA 14.53 L/kg 1compartment NA NA Human Human +DTXSID6027137 Days.Css NA 95 Days PBTK NA NA Human Human +DTXSID6027137 TK.Half.Life NA 432.7 hours 1compartment NA NA Human Human +DTXSID6027137 Css NA 0.819 mg/L 3compartmentss NA 50% Human Human +DTXSID6027137 Css NA 5.346 mg/L 3compartmentss NA 95% Human Human +DTXSID6027137 Css NA 1.311 mg/L PBTK NA 50% Human Human +DTXSID6027137 Css NA 8.012 mg/L PBTK NA 95% Human Human +DTXSID6027137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027137 Fup 0.0132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027137 Vd NA 11.62 L/kg 1compartment NA NA Rat Human +DTXSID6027137 Days.Css NA 57 Days PBTK NA NA Rat Human +DTXSID6027137 TK.Half.Life NA 60.86 hours 1compartment NA NA Rat Human +DTXSID6027137 Css NA 0.008491 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027137 Css NA 0.05014 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027137 Css NA 0.01379 mg/L PBTK NA 50% Rat Human +DTXSID6027137 Css NA 0.08103 mg/L PBTK NA 95% Rat Human DTXSID6027214 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6027214 Fup NA 0.5019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027214 Vd NA 0.5199 L/kg 1compartment NA NA Human Human +DTXSID6027214 Vd NA 0.4513 L/kg 1compartment NA NA Human Human DTXSID6027214 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027214 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human -DTXSID6027214 Css NA 1.512 mg/L 3compartmentss NA 50% Human Human -DTXSID6027214 Css NA 7.701 mg/L 3compartmentss NA 95% Human Human -DTXSID6027214 Css NA 1.128 mg/L PBTK NA 50% Human Human -DTXSID6027214 Css NA 4.79 mg/L PBTK NA 95% Human Human +DTXSID6027214 TK.Half.Life NA 5.82 hours 1compartment NA NA Human Human +DTXSID6027214 Css NA 1.286 mg/L 3compartmentss NA 50% Human Human +DTXSID6027214 Css NA 6.532 mg/L 3compartmentss NA 95% Human Human +DTXSID6027214 Css NA 0.9465 mg/L PBTK NA 50% Human Human +DTXSID6027214 Css NA 4.12 mg/L PBTK NA 95% Human Human DTXSID6027214 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6027214 Fup NA 0.5019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027214 Vd NA 0.5445 L/kg 1compartment NA NA Rat Human +DTXSID6027214 Vd NA 0.4871 L/kg 1compartment NA NA Rat Human DTXSID6027214 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027214 TK.Half.Life NA 2.392 hours 1compartment NA NA Rat Human -DTXSID6027214 Css NA 0.3992 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027214 Css NA 1.832 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027214 Css NA 0.2858 mg/L PBTK NA 50% Rat Human -DTXSID6027214 Css NA 1.075 mg/L PBTK NA 95% Rat Human +DTXSID6027214 TK.Half.Life NA 2.139 hours 1compartment NA NA Rat Human +DTXSID6027214 Css NA 0.02419 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027214 Css NA 0.1617 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027214 Css NA 0.01698 mg/L PBTK NA 50% Rat Human +DTXSID6027214 Css NA 0.1013 mg/L PBTK NA 95% Rat Human DTXSID6027218 Clint 16.13 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID6027218 Fup 0.08962 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID6027218 Vd NA 1.457 L/kg 1compartment NA NA Human Human +DTXSID6027218 Vd NA 0.3608 L/kg 1compartment NA NA Human Human DTXSID6027218 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027218 TK.Half.Life NA 5.51 hours 1compartment NA NA Human Human -DTXSID6027218 Css NA 0.4729 mg/L 3compartmentss NA 50% Human Human -DTXSID6027218 Css NA 3.454 mg/L 3compartmentss NA 95% Human Human -DTXSID6027218 Css NA 0.3104 mg/L PBTK NA 50% Human Human -DTXSID6027218 Css NA 2.175 mg/L PBTK NA 95% Human Human +DTXSID6027218 TK.Half.Life NA 1.237 hours 1compartment NA NA Human Human +DTXSID6027218 Css NA 0.429 mg/L 3compartmentss NA 50% Human Human +DTXSID6027218 Css NA 3.371 mg/L 3compartmentss NA 95% Human Human +DTXSID6027218 Css NA 0.2663 mg/L PBTK NA 50% Human Human +DTXSID6027218 Css NA 2.004 mg/L PBTK NA 95% Human Human DTXSID6027218 Clint 16.13 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID6027218 Fup 0.08962 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID6027218 Vd NA 1.113 L/kg 1compartment NA NA Rat Human +DTXSID6027218 Vd NA 0.3355 L/kg 1compartment NA NA Rat Human DTXSID6027218 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027218 TK.Half.Life NA 2.169 hours 1compartment NA NA Rat Human -DTXSID6027218 Css NA 0.2608 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027218 Css NA 1.479 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027218 Css NA 0.1623 mg/L PBTK NA 50% Rat Human -DTXSID6027218 Css NA 0.8778 mg/L PBTK NA 95% Rat Human +DTXSID6027218 TK.Half.Life NA 0.6985 hours 1compartment NA NA Rat Human +DTXSID6027218 Css NA 0.0564 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027218 Css NA 0.3367 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027218 Css NA 0.03376 mg/L PBTK NA 50% Rat Human +DTXSID6027218 Css NA 0.1948 mg/L PBTK NA 95% Rat Human DTXSID6027262 Clint NA 2.414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6027262 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027262 Vd NA 1.174 L/kg 1compartment NA NA Human Human +DTXSID6027262 Vd NA 1.336 L/kg 1compartment NA NA Human Human DTXSID6027262 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027262 TK.Half.Life NA 1.949 hours 1compartment NA NA Human Human -DTXSID6027262 Css NA 0.1593 mg/L 3compartmentss NA 50% Human Human -DTXSID6027262 Css NA 1.233 mg/L 3compartmentss NA 95% Human Human -DTXSID6027262 Css NA 0.144 mg/L PBTK NA 50% Human Human -DTXSID6027262 Css NA 0.9122 mg/L PBTK NA 95% Human Human +DTXSID6027262 TK.Half.Life NA 2.256 hours 1compartment NA NA Human Human +DTXSID6027262 Css NA 0.1283 mg/L 3compartmentss NA 50% Human Human +DTXSID6027262 Css NA 1.094 mg/L 3compartmentss NA 95% Human Human +DTXSID6027262 Css NA 0.1196 mg/L PBTK NA 50% Human Human +DTXSID6027262 Css NA 0.7916 mg/L PBTK NA 95% Human Human DTXSID6027262 Clint NA 2.414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6027262 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027262 Vd NA 1.14 L/kg 1compartment NA NA Rat Human +DTXSID6027262 Vd NA 1.262 L/kg 1compartment NA NA Rat Human DTXSID6027262 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027262 TK.Half.Life NA 0.9694 hours 1compartment NA NA Rat Human -DTXSID6027262 Css NA 0.06734 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027262 Css NA 0.4615 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027262 Css NA 0.06128 mg/L PBTK NA 50% Rat Human -DTXSID6027262 Css NA 0.2948 mg/L PBTK NA 95% Rat Human +DTXSID6027262 TK.Half.Life NA 1.074 hours 1compartment NA NA Rat Human +DTXSID6027262 Css NA 0.003744 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027262 Css NA 0.03871 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027262 Css NA 0.00347 mg/L PBTK NA 50% Rat Human +DTXSID6027262 Css NA 0.02788 mg/L PBTK NA 95% Rat Human DTXSID6027341 Clint NA 0.9244 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6027341 Fup NA 0.8884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027341 Vd NA 1.696 L/kg 1compartment NA NA Human Human +DTXSID6027341 Vd NA 1.795 L/kg 1compartment NA NA Human Human DTXSID6027341 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027341 TK.Half.Life NA 5.18 hours 1compartment NA NA Human Human -DTXSID6027341 Css NA 0.3164 mg/L 3compartmentss NA 50% Human Human -DTXSID6027341 Css NA 2.101 mg/L 3compartmentss NA 95% Human Human -DTXSID6027341 Css NA 0.309 mg/L PBTK NA 50% Human Human -DTXSID6027341 Css NA 1.474 mg/L PBTK NA 95% Human Human +DTXSID6027341 TK.Half.Life NA 5.479 hours 1compartment NA NA Human Human +DTXSID6027341 Css NA 0.265 mg/L 3compartmentss NA 50% Human Human +DTXSID6027341 Css NA 1.834 mg/L 3compartmentss NA 95% Human Human +DTXSID6027341 Css NA 0.2614 mg/L PBTK NA 50% Human Human +DTXSID6027341 Css NA 1.3 mg/L PBTK NA 95% Human Human DTXSID6027341 Clint NA 0.9244 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6027341 Fup NA 0.8884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027341 Vd NA 1.728 L/kg 1compartment NA NA Rat Human +DTXSID6027341 Vd NA 1.826 L/kg 1compartment NA NA Rat Human DTXSID6027341 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027341 TK.Half.Life NA 2.526 hours 1compartment NA NA Rat Human -DTXSID6027341 Css NA 0.1143 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027341 Css NA 0.782 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027341 Css NA 0.1115 mg/L PBTK NA 50% Rat Human -DTXSID6027341 Css NA 0.5004 mg/L PBTK NA 95% Rat Human +DTXSID6027341 TK.Half.Life NA 2.67 hours 1compartment NA NA Rat Human +DTXSID6027341 Css NA 0.007034 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027341 Css NA 0.06057 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027341 Css NA 0.00685 mg/L PBTK NA 50% Rat Human +DTXSID6027341 Css NA 0.04364 mg/L PBTK NA 95% Rat Human +DTXSID6027343 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027343 Fup 0.0819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027343 Vd NA 1.903 L/kg 1compartment NA NA Human Human +DTXSID6027343 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6027343 TK.Half.Life NA 7.005 hours 1compartment NA NA Human Human +DTXSID6027343 Css NA 0.4258 mg/L 3compartmentss NA 50% Human Human +DTXSID6027343 Css NA 3.083 mg/L 3compartmentss NA 95% Human Human +DTXSID6027343 Css NA 0.2828 mg/L PBTK NA 50% Human Human +DTXSID6027343 Css NA 1.957 mg/L PBTK NA 95% Human Human +DTXSID6027343 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027343 Fup 0.0819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027343 Vd NA 1.437 L/kg 1compartment NA NA Rat Human +DTXSID6027343 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6027343 TK.Half.Life NA 2.393 hours 1compartment NA NA Rat Human +DTXSID6027343 Css NA 0.05512 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027343 Css NA 0.3094 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027343 Css NA 0.03611 mg/L PBTK NA 50% Rat Human +DTXSID6027343 Css NA 0.1922 mg/L PBTK NA 95% Rat Human DTXSID6027345 Clint NA 17.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6027345 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027345 Vd NA 2.938 L/kg 1compartment NA NA Human Human -DTXSID6027345 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID6027345 TK.Half.Life NA 58.54 hours 1compartment NA NA Human Human -DTXSID6027345 Css NA 2.604 mg/L 3compartmentss NA 50% Human Human -DTXSID6027345 Css NA 16.21 mg/L 3compartmentss NA 95% Human Human -DTXSID6027345 Css NA 1.784 mg/L PBTK NA 50% Human Human -DTXSID6027345 Css NA 10.77 mg/L PBTK NA 95% Human Human +DTXSID6027345 Vd NA 0.3618 L/kg 1compartment NA NA Human Human +DTXSID6027345 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6027345 TK.Half.Life NA 3.222 hours 1compartment NA NA Human Human +DTXSID6027345 Css NA 1.491 mg/L 3compartmentss NA 50% Human Human +DTXSID6027345 Css NA 14.24 mg/L 3compartmentss NA 95% Human Human +DTXSID6027345 Css NA 0.8911 mg/L PBTK NA 50% Human Human +DTXSID6027345 Css NA 8.368 mg/L PBTK NA 95% Human Human DTXSID6027345 Clint NA 17.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6027345 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027345 Vd NA 2.199 L/kg 1compartment NA NA Rat Human -DTXSID6027345 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID6027345 TK.Half.Life NA 9.988 hours 1compartment NA NA Rat Human -DTXSID6027345 Css NA 1.457 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027345 Css NA 7.755 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027345 Css NA 0.9512 mg/L PBTK NA 50% Rat Human -DTXSID6027345 Css NA 4.923 mg/L PBTK NA 95% Rat Human -DTXSID6027395 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027395 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027395 Vd NA 1.916 L/kg 1compartment NA NA Human Human -DTXSID6027395 Days.Css NA 37 Days PBTK NA NA Human Human -DTXSID6027395 TK.Half.Life NA 177.9 hours 1compartment NA NA Human Human -DTXSID6027395 Css NA 12.45 mg/L 3compartmentss NA 50% Human Human -DTXSID6027395 Css NA 46.77 mg/L 3compartmentss NA 95% Human Human -DTXSID6027395 Css NA 8.472 mg/L PBTK NA 50% Human Human -DTXSID6027395 Css NA 29.05 mg/L PBTK NA 95% Human Human -DTXSID6027395 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027395 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027395 Vd NA 1.46 L/kg 1compartment NA NA Rat Human -DTXSID6027395 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID6027395 TK.Half.Life NA 31.31 hours 1compartment NA NA Rat Human -DTXSID6027395 Css NA 3.382 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027395 Css NA 10.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027395 Css NA 2.197 mg/L PBTK NA 50% Rat Human -DTXSID6027395 Css NA 6.314 mg/L PBTK NA 95% Rat Human -DTXSID6027397 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027397 Fup NA 0.0301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027397 Vd NA 2.992 L/kg 1compartment NA NA Human Human -DTXSID6027397 Days.Css NA 2371 Days PBTK NA NA Human Human -DTXSID6027397 TK.Half.Life NA 8670 hours 1compartment NA NA Human Human -DTXSID6027397 Css NA 350.9 mg/L 3compartmentss NA 50% Human Human -DTXSID6027397 Css NA 1013 mg/L 3compartmentss NA 95% Human Human -DTXSID6027397 Css NA 242 mg/L PBTK NA 50% Human Human -DTXSID6027397 Css NA 648.4 mg/L PBTK NA 95% Human Human -DTXSID6027397 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027397 Fup NA 0.0301 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027397 Vd NA 2.241 L/kg 1compartment NA NA Rat Human -DTXSID6027397 Days.Css NA 608 Days PBTK NA NA Rat Human -DTXSID6027397 TK.Half.Life NA 652.7 hours 1compartment NA NA Rat Human -DTXSID6027397 Css NA 95.04 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027397 Css NA 225.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027397 Css NA 62.49 mg/L PBTK NA 50% Rat Human -DTXSID6027397 Css NA 134.2 mg/L PBTK NA 95% Rat Human -DTXSID6027503 Clint NA 4.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027503 Fup NA 0.5173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027503 Vd NA 2.186 L/kg 1compartment NA NA Human Human -DTXSID6027503 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027503 TK.Half.Life NA 3.784 hours 1compartment NA NA Human Human -DTXSID6027503 Css NA 0.1159 mg/L 3compartmentss NA 50% Human Human -DTXSID6027503 Css NA 0.971 mg/L 3compartmentss NA 95% Human Human -DTXSID6027503 Css NA 0.1256 mg/L PBTK NA 50% Human Human -DTXSID6027503 Css NA 0.7728 mg/L PBTK NA 95% Human Human -DTXSID6027503 Clint NA 4.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027503 Fup NA 0.5173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027503 Vd NA 2.154 L/kg 1compartment NA NA Rat Human +DTXSID6027345 Vd NA 0.3023 L/kg 1compartment NA NA Rat Human +DTXSID6027345 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6027345 TK.Half.Life NA 1.74 hours 1compartment NA NA Rat Human +DTXSID6027345 Css NA 0.1945 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027345 Css NA 1.431 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027345 Css NA 0.1119 mg/L PBTK NA 50% Rat Human +DTXSID6027345 Css NA 0.8076 mg/L PBTK NA 95% Rat Human +DTXSID6027397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027397 Fup 0.012 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027397 Vd NA 2.739 L/kg 1compartment NA NA Human Human +DTXSID6027397 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID6027397 TK.Half.Life NA 50.23 hours 1compartment NA NA Human Human +DTXSID6027397 Css NA 2.171 mg/L 3compartmentss NA 50% Human Human +DTXSID6027397 Css NA 16.37 mg/L 3compartmentss NA 95% Human Human +DTXSID6027397 Css NA 1.453 mg/L PBTK NA 50% Human Human +DTXSID6027397 Css NA 10.37 mg/L PBTK NA 95% Human Human +DTXSID6027397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027397 Fup 0.012 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027397 Vd NA 2.045 L/kg 1compartment NA NA Rat Human +DTXSID6027397 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6027397 TK.Half.Life NA 10.32 hours 1compartment NA NA Rat Human +DTXSID6027397 Css NA 0.1104 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027397 Css NA 0.8651 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027397 Css NA 0.07151 mg/L PBTK NA 50% Rat Human +DTXSID6027397 Css NA 0.5402 mg/L PBTK NA 95% Rat Human +DTXSID6027503 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027503 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027503 Vd NA 1.648 L/kg 1compartment NA NA Human Human +DTXSID6027503 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6027503 TK.Half.Life NA 15.75 hours 1compartment NA NA Human Human +DTXSID6027503 Css NA 0.8972 mg/L 3compartmentss NA 50% Human Human +DTXSID6027503 Css NA 6.747 mg/L 3compartmentss NA 95% Human Human +DTXSID6027503 Css NA 0.8708 mg/L PBTK NA 50% Human Human +DTXSID6027503 Css NA 4.524 mg/L PBTK NA 95% Human Human +DTXSID6027503 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027503 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027503 Vd NA 1.626 L/kg 1compartment NA NA Rat Human DTXSID6027503 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027503 TK.Half.Life NA 2.118 hours 1compartment NA NA Rat Human -DTXSID6027503 Css NA 0.05456 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027503 Css NA 0.4074 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027503 Css NA 0.0586 mg/L PBTK NA 50% Rat Human -DTXSID6027503 Css NA 0.2883 mg/L PBTK NA 95% Rat Human -DTXSID6027507 Clint NA 120.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027507 Fup NA 0.192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027507 Vd NA 2.146 L/kg 1compartment NA NA Human Human +DTXSID6027503 TK.Half.Life NA 5.295 hours 1compartment NA NA Rat Human +DTXSID6027503 Css NA 0.05358 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027503 Css NA 0.3812 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027503 Css NA 0.0529 mg/L PBTK NA 50% Rat Human +DTXSID6027503 Css NA 0.2473 mg/L PBTK NA 95% Rat Human +DTXSID6027507 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027507 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027507 Vd NA 1.83 L/kg 1compartment NA NA Human Human DTXSID6027507 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027507 TK.Half.Life NA 2.232 hours 1compartment NA NA Human Human -DTXSID6027507 Css NA 0.03388 mg/L 3compartmentss NA 50% Human Human -DTXSID6027507 Css NA 0.2322 mg/L 3compartmentss NA 95% Human Human -DTXSID6027507 Css NA 0.02446 mg/L PBTK NA 50% Human Human -DTXSID6027507 Css NA 0.1598 mg/L PBTK NA 95% Human Human -DTXSID6027507 Clint NA 120.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027507 Fup NA 0.192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027507 Vd NA 1.647 L/kg 1compartment NA NA Rat Human +DTXSID6027507 TK.Half.Life NA 4.923 hours 1compartment NA NA Human Human +DTXSID6027507 Css NA 0.2688 mg/L 3compartmentss NA 50% Human Human +DTXSID6027507 Css NA 1.992 mg/L 3compartmentss NA 95% Human Human +DTXSID6027507 Css NA 0.1836 mg/L PBTK NA 50% Human Human +DTXSID6027507 Css NA 1.272 mg/L PBTK NA 95% Human Human +DTXSID6027507 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027507 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027507 Vd NA 1.397 L/kg 1compartment NA NA Rat Human DTXSID6027507 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027507 TK.Half.Life NA 0.7379 hours 1compartment NA NA Rat Human -DTXSID6027507 Css NA 0.0187 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027507 Css NA 0.1061 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027507 Css NA 0.013 mg/L PBTK NA 50% Rat Human -DTXSID6027507 Css NA 0.07073 mg/L PBTK NA 95% Rat Human -DTXSID6027509 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027509 Fup NA 0.837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027509 Vd NA 0.8819 L/kg 1compartment NA NA Human Human +DTXSID6027507 TK.Half.Life NA 1.742 hours 1compartment NA NA Rat Human +DTXSID6027507 Css NA 0.03466 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027507 Css NA 0.198 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027507 Css NA 0.02325 mg/L PBTK NA 50% Rat Human +DTXSID6027507 Css NA 0.127 mg/L PBTK NA 95% Rat Human +DTXSID6027509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027509 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6027509 Vd NA 0.9186 L/kg 1compartment NA NA Human Human DTXSID6027509 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027509 TK.Half.Life NA 6.897 hours 1compartment NA NA Human Human -DTXSID6027509 Css NA 0.9552 mg/L 3compartmentss NA 50% Human Human -DTXSID6027509 Css NA 5.697 mg/L 3compartmentss NA 95% Human Human -DTXSID6027509 Css NA 0.8054 mg/L PBTK NA 50% Human Human -DTXSID6027509 Css NA 3.775 mg/L PBTK NA 95% Human Human -DTXSID6027509 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027509 Fup NA 0.837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027509 Vd NA 0.8771 L/kg 1compartment NA NA Rat Human +DTXSID6027509 TK.Half.Life NA 0.8065 hours 1compartment NA NA Human Human +DTXSID6027509 Css NA 0.03138 mg/L 3compartmentss NA 50% Human Human +DTXSID6027509 Css NA 0.3417 mg/L 3compartmentss NA 95% Human Human +DTXSID6027509 Css NA 0.02583 mg/L PBTK NA 50% Human Human +DTXSID6027509 Css NA 0.2386 mg/L PBTK NA 95% Human Human +DTXSID6027509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027509 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6027509 Vd NA 0.8707 L/kg 1compartment NA NA Rat Human DTXSID6027509 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027509 TK.Half.Life NA 2.317 hours 1compartment NA NA Rat Human -DTXSID6027509 Css NA 0.2428 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027509 Css NA 1.488 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027509 Css NA 0.1997 mg/L PBTK NA 50% Rat Human -DTXSID6027509 Css NA 0.8967 mg/L PBTK NA 95% Rat Human +DTXSID6027509 TK.Half.Life NA 0.3765 hours 1compartment NA NA Rat Human +DTXSID6027509 Css NA 0.003816 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027509 Css NA 0.0352 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027509 Css NA 0.003175 mg/L PBTK NA 50% Rat Human +DTXSID6027509 Css NA 0.02345 mg/L PBTK NA 95% Rat Human DTXSID6027551 Clint NA 0.4801 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6027551 Fup NA 0.2239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027551 Vd NA 0.4288 L/kg 1compartment NA NA Human Human +DTXSID6027551 Vd NA 0.3149 L/kg 1compartment NA NA Human Human DTXSID6027551 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027551 TK.Half.Life NA 6.897 hours 1compartment NA NA Human Human -DTXSID6027551 Css NA 1.894 mg/L 3compartmentss NA 50% Human Human -DTXSID6027551 Css NA 7.621 mg/L 3compartmentss NA 95% Human Human -DTXSID6027551 Css NA 1.285 mg/L PBTK NA 50% Human Human -DTXSID6027551 Css NA 4.761 mg/L PBTK NA 95% Human Human +DTXSID6027551 TK.Half.Life NA 1.714 hours 1compartment NA NA Human Human +DTXSID6027551 Css NA 0.3338 mg/L 3compartmentss NA 50% Human Human +DTXSID6027551 Css NA 1.849 mg/L 3compartmentss NA 95% Human Human +DTXSID6027551 Css NA 0.2172 mg/L PBTK NA 50% Human Human +DTXSID6027551 Css NA 1.121 mg/L PBTK NA 95% Human Human DTXSID6027551 Clint NA 0.4801 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6027551 Fup NA 0.2239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027551 Vd NA 0.4339 L/kg 1compartment NA NA Rat Human +DTXSID6027551 Vd NA 0.3333 L/kg 1compartment NA NA Rat Human DTXSID6027551 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027551 TK.Half.Life NA 3.074 hours 1compartment NA NA Rat Human -DTXSID6027551 Css NA 0.6956 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027551 Css NA 2.254 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027551 Css NA 0.4486 mg/L PBTK NA 50% Rat Human -DTXSID6027551 Css NA 1.3 mg/L PBTK NA 95% Rat Human -DTXSID6027713 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027713 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027713 Vd NA 7.825 L/kg 1compartment NA NA Human Human -DTXSID6027713 Days.Css NA 11150 Days PBTK NA NA Human Human -DTXSID6027713 TK.Half.Life NA 372900 hours 1compartment NA NA Human Human -DTXSID6027713 Css NA 3592 mg/L 3compartmentss NA 50% Human Human -DTXSID6027713 Css NA 8395 mg/L 3compartmentss NA 95% Human Human -DTXSID6027713 Css NA 3657 mg/L PBTK NA 50% Human Human -DTXSID6027713 Css NA 7848 mg/L PBTK NA 95% Human Human -DTXSID6027713 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027713 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027713 Vd NA 6.093 L/kg 1compartment NA NA Rat Human -DTXSID6027713 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6027713 TK.Half.Life NA 24260 hours 1compartment NA NA Rat Human -DTXSID6027713 Css NA 971.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027713 Css NA 1487 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027713 Css NA 984.3 mg/L PBTK NA 50% Rat Human -DTXSID6027713 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID6027921 Clint NA 434.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027921 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027921 Vd NA 2.352 L/kg 1compartment NA NA Human Human -DTXSID6027921 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027921 TK.Half.Life NA 3.274 hours 1compartment NA NA Human Human -DTXSID6027921 Css NA 0.08374 mg/L 3compartmentss NA 50% Human Human -DTXSID6027921 Css NA 0.6651 mg/L 3compartmentss NA 95% Human Human -DTXSID6027921 Css NA 0.05508 mg/L PBTK NA 50% Human Human -DTXSID6027921 Css NA 0.421 mg/L PBTK NA 95% Human Human -DTXSID6027921 Clint NA 434.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027921 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027921 Vd NA 1.753 L/kg 1compartment NA NA Rat Human -DTXSID6027921 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027921 TK.Half.Life NA 0.996 hours 1compartment NA NA Rat Human -DTXSID6027921 Css NA 0.04762 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027921 Css NA 0.3108 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027921 Css NA 0.02944 mg/L PBTK NA 50% Rat Human -DTXSID6027921 Css NA 0.1855 mg/L PBTK NA 95% Rat Human -DTXSID6027923 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027923 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027923 Vd NA 0.5326 L/kg 1compartment NA NA Human Human -DTXSID6027923 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6027923 TK.Half.Life NA 9.524 hours 1compartment NA NA Human Human -DTXSID6027923 Css NA 3.125 mg/L 3compartmentss NA 50% Human Human -DTXSID6027923 Css NA 32.01 mg/L 3compartmentss NA 95% Human Human -DTXSID6027923 Css NA 1.898 mg/L PBTK NA 50% Human Human -DTXSID6027923 Css NA 18.94 mg/L PBTK NA 95% Human Human -DTXSID6027923 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027923 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027923 Vd NA 0.4356 L/kg 1compartment NA NA Rat Human -DTXSID6027923 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6027923 TK.Half.Life NA 5.154 hours 1compartment NA NA Rat Human -DTXSID6027923 Css NA 1.819 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027923 Css NA 15.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027923 Css NA 1.034 mg/L PBTK NA 50% Rat Human -DTXSID6027923 Css NA 8.561 mg/L PBTK NA 95% Rat Human -DTXSID6027925 Clint NA 74.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027925 Fup NA 0.0285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027925 Vd NA 3.058 L/kg 1compartment NA NA Human Human -DTXSID6027925 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6027925 TK.Half.Life NA 20.52 hours 1compartment NA NA Human Human -DTXSID6027925 Css NA 0.761 mg/L 3compartmentss NA 50% Human Human -DTXSID6027925 Css NA 4.959 mg/L 3compartmentss NA 95% Human Human -DTXSID6027925 Css NA 0.5272 mg/L PBTK NA 50% Human Human -DTXSID6027925 Css NA 3.306 mg/L PBTK NA 95% Human Human -DTXSID6027925 Clint NA 74.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027925 Fup NA 0.0285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027925 Vd NA 2.29 L/kg 1compartment NA NA Rat Human -DTXSID6027925 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6027925 TK.Half.Life NA 3.373 hours 1compartment NA NA Rat Human -DTXSID6027925 Css NA 0.4244 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027925 Css NA 2.272 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027925 Css NA 0.2806 mg/L PBTK NA 50% Rat Human -DTXSID6027925 Css NA 1.457 mg/L PBTK NA 95% Rat Human -DTXSID6027975 Clint NA 25.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027975 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6027975 Vd NA 1020 L/kg 1compartment NA NA Human Human -DTXSID6027975 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6027975 TK.Half.Life NA 26080 hours 1compartment NA NA Human Human -DTXSID6027975 Css NA 0.01311 mg/L 3compartmentss NA 50% Human Human -DTXSID6027975 Css NA 0.07704 mg/L 3compartmentss NA 95% Human Human -DTXSID6027975 Css NA 2.125 mg/L PBTK NA 50% Human Human -DTXSID6027975 Css NA 11.51 mg/L PBTK NA 95% Human Human -DTXSID6027975 Clint NA 25.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027975 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6027975 Vd NA 934.1 L/kg 1compartment NA NA Rat Human -DTXSID6027975 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6027975 TK.Half.Life NA 4279 hours 1compartment NA NA Rat Human -DTXSID6027975 Css NA 0.006644 mg/L 3compartmentss NA 50% Rat Human -DTXSID6027975 Css NA 0.02955 mg/L 3compartmentss NA 95% Rat Human -DTXSID6027975 Css NA 1.161 mg/L PBTK NA 50% Rat Human -DTXSID6027975 Css NA 5.078 mg/L PBTK NA 95% Rat Human -DTXSID6028028 Clint NA 3.071 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6028028 Fup NA 0.5428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6028028 Vd NA 0.411 L/kg 1compartment NA NA Human Human +DTXSID6027551 TK.Half.Life NA 1.026 hours 1compartment NA NA Rat Human +DTXSID6027551 Css NA 0.003046 mg/L 3compartmentss NA 50% Rat Human +DTXSID6027551 Css NA 0.0146 mg/L 3compartmentss NA 95% Rat Human +DTXSID6027551 Css NA 0.001872 mg/L PBTK NA 50% Rat Human +DTXSID6027551 Css NA 0.008434 mg/L PBTK NA 95% Rat Human +DTXSID60278061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60278061 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60278061 Vd NA 1.409 L/kg 1compartment NA NA Human Human +DTXSID60278061 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60278061 TK.Half.Life NA 1.638 hours 1compartment NA NA Human Human +DTXSID60278061 Css NA 0.05507 mg/L 3compartmentss NA 50% Human Human +DTXSID60278061 Css NA 0.4127 mg/L 3compartmentss NA 95% Human Human +DTXSID60278061 Css NA 0.04316 mg/L PBTK NA 50% Human Human +DTXSID60278061 Css NA 0.2957 mg/L PBTK NA 95% Human Human +DTXSID60278061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60278061 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60278061 Vd NA 1.174 L/kg 1compartment NA NA Rat Human +DTXSID60278061 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60278061 TK.Half.Life NA 0.6704 hours 1compartment NA NA Rat Human +DTXSID60278061 Css NA 0.006701 mg/L 3compartmentss NA 50% Rat Human +DTXSID60278061 Css NA 0.04088 mg/L 3compartmentss NA 95% Rat Human +DTXSID60278061 Css NA 0.005314 mg/L PBTK NA 50% Rat Human +DTXSID60278061 Css NA 0.02797 mg/L PBTK NA 95% Rat Human +DTXSID60278268 Clint 30.9 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60278268 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60278268 Vd NA 0.7589 L/kg 1compartment NA NA Human Human +DTXSID60278268 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60278268 TK.Half.Life NA 0.783 hours 1compartment NA NA Human Human +DTXSID60278268 Css NA 0.0365 mg/L 3compartmentss NA 50% Human Human +DTXSID60278268 Css NA 0.2948 mg/L 3compartmentss NA 95% Human Human +DTXSID60278268 Css NA 0.02735 mg/L PBTK NA 50% Human Human +DTXSID60278268 Css NA 0.2004 mg/L PBTK NA 95% Human Human +DTXSID60278268 Clint 30.9 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60278268 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60278268 Vd NA 0.7057 L/kg 1compartment NA NA Rat Human +DTXSID60278268 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60278268 TK.Half.Life NA 0.3648 hours 1compartment NA NA Rat Human +DTXSID60278268 Css NA 0.004575 mg/L 3compartmentss NA 50% Rat Human +DTXSID60278268 Css NA 0.02945 mg/L 3compartmentss NA 95% Rat Human +DTXSID60278268 Css NA 0.003446 mg/L PBTK NA 50% Rat Human +DTXSID60278268 Css NA 0.01974 mg/L PBTK NA 95% Rat Human +DTXSID6028028 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6028028 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6028028 Vd NA 0.4523 L/kg 1compartment NA NA Human Human DTXSID6028028 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6028028 TK.Half.Life NA 0.98 hours 1compartment NA NA Human Human -DTXSID6028028 Css NA 0.2383 mg/L 3compartmentss NA 50% Human Human -DTXSID6028028 Css NA 1.662 mg/L 3compartmentss NA 95% Human Human -DTXSID6028028 Css NA 0.1704 mg/L PBTK NA 50% Human Human -DTXSID6028028 Css NA 1.041 mg/L PBTK NA 95% Human Human -DTXSID6028028 Clint NA 3.071 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6028028 Fup NA 0.5428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6028028 Vd NA 0.4255 L/kg 1compartment NA NA Rat Human +DTXSID6028028 TK.Half.Life NA 3.644 hours 1compartment NA NA Human Human +DTXSID6028028 Css NA 1.068 mg/L 3compartmentss NA 50% Human Human +DTXSID6028028 Css NA 5.763 mg/L 3compartmentss NA 95% Human Human +DTXSID6028028 Css NA 0.7918 mg/L PBTK NA 50% Human Human +DTXSID6028028 Css NA 3.586 mg/L PBTK NA 95% Human Human +DTXSID6028028 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6028028 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6028028 Vd NA 0.4787 L/kg 1compartment NA NA Rat Human DTXSID6028028 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6028028 TK.Half.Life NA 0.5484 hours 1compartment NA NA Rat Human -DTXSID6028028 Css NA 0.1125 mg/L 3compartmentss NA 50% Rat Human -DTXSID6028028 Css NA 0.6825 mg/L 3compartmentss NA 95% Rat Human -DTXSID6028028 Css NA 0.07677 mg/L PBTK NA 50% Rat Human -DTXSID6028028 Css NA 0.3923 mg/L PBTK NA 95% Rat Human -DTXSID6028492 Clint NA 136.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6028492 Fup NA 0.3621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6028492 Vd NA 2.024 L/kg 1compartment NA NA Human Human -DTXSID6028492 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6028492 TK.Half.Life NA 1.639 hours 1compartment NA NA Human Human -DTXSID6028492 Css NA 0.01366 mg/L 3compartmentss NA 50% Human Human -DTXSID6028492 Css NA 0.1001 mg/L 3compartmentss NA 95% Human Human -DTXSID6028492 Css NA 0.0106 mg/L PBTK NA 50% Human Human -DTXSID6028492 Css NA 0.07033 mg/L PBTK NA 95% Human Human -DTXSID6028492 Clint NA 136.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6028492 Fup NA 0.3621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6028492 Vd NA 1.6 L/kg 1compartment NA NA Rat Human -DTXSID6028492 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6028492 TK.Half.Life NA 0.5635 hours 1compartment NA NA Rat Human -DTXSID6028492 Css NA 0.007377 mg/L 3compartmentss NA 50% Rat Human -DTXSID6028492 Css NA 0.04461 mg/L 3compartmentss NA 95% Rat Human -DTXSID6028492 Css NA 0.005572 mg/L PBTK NA 50% Rat Human -DTXSID6028492 Css NA 0.0319 mg/L PBTK NA 95% Rat Human -DTXSID6029121 Clint NA 50.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029121 Fup NA 0.0241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029121 Vd NA 3.274 L/kg 1compartment NA NA Human Human -DTXSID6029121 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID6029121 TK.Half.Life NA 43.62 hours 1compartment NA NA Human Human -DTXSID6029121 Css NA 1.461 mg/L 3compartmentss NA 50% Human Human -DTXSID6029121 Css NA 8.089 mg/L 3compartmentss NA 95% Human Human -DTXSID6029121 Css NA 1.033 mg/L PBTK NA 50% Human Human -DTXSID6029121 Css NA 5.728 mg/L PBTK NA 95% Human Human -DTXSID6029121 Clint NA 50.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029121 Fup NA 0.0241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029121 Vd NA 2.457 L/kg 1compartment NA NA Rat Human -DTXSID6029121 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6029121 TK.Half.Life NA 6.107 hours 1compartment NA NA Rat Human -DTXSID6029121 Css NA 0.8302 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029121 Css NA 3.508 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029121 Css NA 0.5585 mg/L PBTK NA 50% Rat Human -DTXSID6029121 Css NA 2.337 mg/L PBTK NA 95% Rat Human -DTXSID6029127 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029127 Fup NA 0.9168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029127 Vd NA 0.6184 L/kg 1compartment NA NA Human Human +DTXSID6028028 TK.Half.Life NA 1.315 hours 1compartment NA NA Rat Human +DTXSID6028028 Css NA 0.06364 mg/L 3compartmentss NA 50% Rat Human +DTXSID6028028 Css NA 0.3379 mg/L 3compartmentss NA 95% Rat Human +DTXSID6028028 Css NA 0.04692 mg/L PBTK NA 50% Rat Human +DTXSID6028028 Css NA 0.203 mg/L PBTK NA 95% Rat Human +DTXSID60281151 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60281151 Fup 0.235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60281151 Vd NA 2.006 L/kg 1compartment NA NA Human Human +DTXSID60281151 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60281151 TK.Half.Life NA 3.683 hours 1compartment NA NA Human Human +DTXSID60281151 Css NA 0.1279 mg/L 3compartmentss NA 50% Human Human +DTXSID60281151 Css NA 0.8747 mg/L 3compartmentss NA 95% Human Human +DTXSID60281151 Css NA 0.09426 mg/L PBTK NA 50% Human Human +DTXSID60281151 Css NA 0.6121 mg/L PBTK NA 95% Human Human +DTXSID60281151 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60281151 Fup 0.235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60281151 Vd NA 1.557 L/kg 1compartment NA NA Rat Human +DTXSID60281151 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60281151 TK.Half.Life NA 1.265 hours 1compartment NA NA Rat Human +DTXSID60281151 Css NA 0.01633 mg/L 3compartmentss NA 50% Rat Human +DTXSID60281151 Css NA 0.08291 mg/L 3compartmentss NA 95% Rat Human +DTXSID60281151 Css NA 0.012 mg/L PBTK NA 50% Rat Human +DTXSID60281151 Css NA 0.05805 mg/L PBTK NA 95% Rat Human +DTXSID6029121 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029121 Fup 0.00553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029121 Vd NA 3.234 L/kg 1compartment NA NA Human Human +DTXSID6029121 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID6029121 TK.Half.Life NA 99.19 hours 1compartment NA NA Human Human +DTXSID6029121 Css NA 3.457 mg/L 3compartmentss NA 50% Human Human +DTXSID6029121 Css NA 20.49 mg/L 3compartmentss NA 95% Human Human +DTXSID6029121 Css NA 2.418 mg/L PBTK NA 50% Human Human +DTXSID6029121 Css NA 14.4 mg/L PBTK NA 95% Human Human +DTXSID6029121 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029121 Fup 0.00553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029121 Vd NA 2.426 L/kg 1compartment NA NA Rat Human +DTXSID6029121 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID6029121 TK.Half.Life NA 13.91 hours 1compartment NA NA Rat Human +DTXSID6029121 Css NA 0.4568 mg/L 3compartmentss NA 50% Rat Human +DTXSID6029121 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human +DTXSID6029121 Css NA 0.317 mg/L PBTK NA 50% Rat Human +DTXSID6029121 Css NA 1.548 mg/L PBTK NA 95% Rat Human +DTXSID6029123 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029123 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029123 Vd NA 0.6258 L/kg 1compartment NA NA Human Human +DTXSID6029123 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6029123 TK.Half.Life NA 8.901 hours 1compartment NA NA Human Human +DTXSID6029123 Css NA 1.522 mg/L 3compartmentss NA 50% Human Human +DTXSID6029123 Css NA 7.333 mg/L 3compartmentss NA 95% Human Human +DTXSID6029123 Css NA 1.158 mg/L PBTK NA 50% Human Human +DTXSID6029123 Css NA 4.688 mg/L PBTK NA 95% Human Human +DTXSID6029123 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029123 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029123 Vd NA 0.6259 L/kg 1compartment NA NA Rat Human +DTXSID6029123 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6029123 TK.Half.Life NA 3.023 hours 1compartment NA NA Rat Human +DTXSID6029123 Css NA 0.09725 mg/L 3compartmentss NA 50% Rat Human +DTXSID6029123 Css NA 0.3944 mg/L 3compartmentss NA 95% Rat Human +DTXSID6029123 Css NA 0.07301 mg/L PBTK NA 50% Rat Human +DTXSID6029123 Css NA 0.2434 mg/L PBTK NA 95% Rat Human +DTXSID6029127 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029127 Fup 0.848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029127 Vd NA 0.6963 L/kg 1compartment NA NA Human Human DTXSID6029127 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6029127 TK.Half.Life NA 4.37 hours 1compartment NA NA Human Human -DTXSID6029127 Css NA 0.9377 mg/L 3compartmentss NA 50% Human Human -DTXSID6029127 Css NA 3.361 mg/L 3compartmentss NA 95% Human Human -DTXSID6029127 Css NA 0.737 mg/L PBTK NA 50% Human Human -DTXSID6029127 Css NA 2.257 mg/L PBTK NA 95% Human Human -DTXSID6029127 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029127 Fup NA 0.9168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029127 Vd NA 0.6333 L/kg 1compartment NA NA Rat Human +DTXSID6029127 TK.Half.Life NA 0.5497 hours 1compartment NA NA Human Human +DTXSID6029127 Css NA 0.02112 mg/L 3compartmentss NA 50% Human Human +DTXSID6029127 Css NA 0.2318 mg/L 3compartmentss NA 95% Human Human +DTXSID6029127 Css NA 0.01653 mg/L PBTK NA 50% Human Human +DTXSID6029127 Css NA 0.158 mg/L PBTK NA 95% Human Human +DTXSID6029127 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029127 Fup 0.848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029127 Vd NA 0.6931 L/kg 1compartment NA NA Rat Human DTXSID6029127 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6029127 TK.Half.Life NA 1.524 hours 1compartment NA NA Rat Human -DTXSID6029127 Css NA 0.2415 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029127 Css NA 0.8172 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029127 Css NA 0.1835 mg/L PBTK NA 50% Rat Human -DTXSID6029127 Css NA 0.5063 mg/L PBTK NA 95% Rat Human -DTXSID6029202 Clint NA 987.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029202 Fup NA 0.0612 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029202 Vd NA 0.995 L/kg 1compartment NA NA Human Human -DTXSID6029202 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6029202 TK.Half.Life NA 0.9507 hours 1compartment NA NA Human Human -DTXSID6029202 Css NA 0.0114 mg/L 3compartmentss NA 50% Human Human -DTXSID6029202 Css NA 0.09138 mg/L 3compartmentss NA 95% Human Human -DTXSID6029202 Css NA 0.007184 mg/L PBTK NA 50% Human Human -DTXSID6029202 Css NA 0.05643 mg/L PBTK NA 95% Human Human -DTXSID6029202 Clint NA 987.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029202 Fup NA 0.0612 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029202 Vd NA 0.7658 L/kg 1compartment NA NA Rat Human -DTXSID6029202 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6029202 TK.Half.Life NA 0.3293 hours 1compartment NA NA Rat Human -DTXSID6029202 Css NA 0.00657 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029202 Css NA 0.04424 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029202 Css NA 0.003886 mg/L PBTK NA 50% Rat Human -DTXSID6029202 Css NA 0.02515 mg/L PBTK NA 95% Rat Human -DTXSID6029254 Clint NA 0.7518 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029254 Fup NA 0.1379 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029254 Vd NA 0.5166 L/kg 1compartment NA NA Human Human -DTXSID6029254 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6029254 TK.Half.Life NA 10.94 hours 1compartment NA NA Human Human -DTXSID6029254 Css NA 2.87 mg/L 3compartmentss NA 50% Human Human -DTXSID6029254 Css NA 15.2 mg/L 3compartmentss NA 95% Human Human -DTXSID6029254 Css NA 1.958 mg/L PBTK NA 50% Human Human -DTXSID6029254 Css NA 9.097 mg/L PBTK NA 95% Human Human -DTXSID6029254 Clint NA 0.7518 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029254 Fup NA 0.1379 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029254 Vd NA 0.4777 L/kg 1compartment NA NA Rat Human +DTXSID6029127 TK.Half.Life NA 0.2617 hours 1compartment NA NA Rat Human +DTXSID6029127 Css NA 0.0007355 mg/L 3compartmentss NA 50% Rat Human +DTXSID6029127 Css NA 0.009057 mg/L 3compartmentss NA 95% Rat Human +DTXSID6029127 Css NA 0.0005639 mg/L PBTK NA 50% Rat Human +DTXSID6029127 Css NA 0.005996 mg/L PBTK NA 95% Rat Human +DTXSID6029202 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029202 Fup 0.055 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029202 Vd NA 2.202 L/kg 1compartment NA NA Human Human +DTXSID6029202 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID6029202 TK.Half.Life NA 36.33 hours 1compartment NA NA Human Human +DTXSID6029202 Css NA 2.32 mg/L 3compartmentss NA 50% Human Human +DTXSID6029202 Css NA 13.64 mg/L 3compartmentss NA 95% Human Human +DTXSID6029202 Css NA 1.545 mg/L PBTK NA 50% Human Human +DTXSID6029202 Css NA 8.55 mg/L PBTK NA 95% Human Human +DTXSID6029202 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029202 Fup 0.055 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029202 Vd NA 1.65 L/kg 1compartment NA NA Rat Human +DTXSID6029202 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6029202 TK.Half.Life NA 10.34 hours 1compartment NA NA Rat Human +DTXSID6029202 Css NA 0.2882 mg/L 3compartmentss NA 50% Rat Human +DTXSID6029202 Css NA 1.291 mg/L 3compartmentss NA 95% Rat Human +DTXSID6029202 Css NA 0.1876 mg/L PBTK NA 50% Rat Human +DTXSID6029202 Css NA 0.8052 mg/L PBTK NA 95% Rat Human +DTXSID6029254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029254 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029254 Vd NA 0.6125 L/kg 1compartment NA NA Human Human +DTXSID6029254 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6029254 TK.Half.Life NA 0.9176 hours 1compartment NA NA Human Human +DTXSID6029254 Css NA 0.09046 mg/L 3compartmentss NA 50% Human Human +DTXSID6029254 Css NA 0.6252 mg/L 3compartmentss NA 95% Human Human +DTXSID6029254 Css NA 0.06648 mg/L PBTK NA 50% Human Human +DTXSID6029254 Css NA 0.4319 mg/L PBTK NA 95% Human Human +DTXSID6029254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029254 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029254 Vd NA 0.575 L/kg 1compartment NA NA Rat Human DTXSID6029254 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6029254 TK.Half.Life NA 4.761 hours 1compartment NA NA Rat Human -DTXSID6029254 Css NA 1.15 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029254 Css NA 4.872 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029254 Css NA 0.7346 mg/L PBTK NA 50% Rat Human -DTXSID6029254 Css NA 2.759 mg/L PBTK NA 95% Rat Human -DTXSID6029335 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029335 Fup NA 0.039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029335 Vd NA 3.059 L/kg 1compartment NA NA Human Human -DTXSID6029335 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6029335 TK.Half.Life NA 12530 hours 1compartment NA NA Human Human -DTXSID6029335 Css NA 477.5 mg/L 3compartmentss NA 50% Human Human -DTXSID6029335 Css NA 1324 mg/L 3compartmentss NA 95% Human Human -DTXSID6029335 Css NA 331.6 mg/L PBTK NA 50% Human Human -DTXSID6029335 Css NA 865.9 mg/L PBTK NA 95% Human Human -DTXSID6029335 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029335 Fup NA 0.039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029335 Vd NA 2.293 L/kg 1compartment NA NA Rat Human -DTXSID6029335 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID6029335 TK.Half.Life NA 861.5 hours 1compartment NA NA Rat Human -DTXSID6029335 Css NA 130.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029335 Css NA 296.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029335 Css NA 86.68 mg/L PBTK NA 50% Rat Human -DTXSID6029335 Css NA 177.6 mg/L PBTK NA 95% Rat Human +DTXSID6029254 TK.Half.Life NA 0.4741 hours 1compartment NA NA Rat Human +DTXSID6029254 Css NA 0.01122 mg/L 3compartmentss NA 50% Rat Human +DTXSID6029254 Css NA 0.06361 mg/L 3compartmentss NA 95% Rat Human +DTXSID6029254 Css NA 0.008204 mg/L PBTK NA 50% Rat Human +DTXSID6029254 Css NA 0.04229 mg/L PBTK NA 95% Rat Human DTXSID6029626 Clint NA 0.001034 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6029626 Fup NA 0.2682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029626 Vd NA 0.3421 L/kg 1compartment NA NA Human Human +DTXSID6029626 Vd NA 0.3389 L/kg 1compartment NA NA Human Human DTXSID6029626 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6029626 TK.Half.Life NA 8.236 hours 1compartment NA NA Human Human -DTXSID6029626 Css NA 2.95 mg/L 3compartmentss NA 50% Human Human -DTXSID6029626 Css NA 11.04 mg/L 3compartmentss NA 95% Human Human -DTXSID6029626 Css NA 1.969 mg/L PBTK NA 50% Human Human -DTXSID6029626 Css NA 6.81 mg/L PBTK NA 95% Human Human +DTXSID6029626 TK.Half.Life NA 8.159 hours 1compartment NA NA Human Human +DTXSID6029626 Css NA 2.516 mg/L 3compartmentss NA 50% Human Human +DTXSID6029626 Css NA 9.766 mg/L 3compartmentss NA 95% Human Human +DTXSID6029626 Css NA 1.672 mg/L PBTK NA 50% Human Human +DTXSID6029626 Css NA 6.017 mg/L PBTK NA 95% Human Human DTXSID6029626 Clint NA 0.001034 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6029626 Fup NA 0.2682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029626 Vd NA 0.3534 L/kg 1compartment NA NA Rat Human +DTXSID6029626 Vd NA 0.3507 L/kg 1compartment NA NA Rat Human DTXSID6029626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6029626 TK.Half.Life NA 2.903 hours 1compartment NA NA Rat Human -DTXSID6029626 Css NA 0.8222 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029626 Css NA 2.62 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029626 Css NA 0.5178 mg/L PBTK NA 50% Rat Human -DTXSID6029626 Css NA 1.496 mg/L PBTK NA 95% Rat Human -DTXSID6029670 Clint NA 11.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029670 Fup NA 0.2379 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029670 Vd NA 4.409 L/kg 1compartment NA NA Human Human +DTXSID6029626 TK.Half.Life NA 2.88 hours 1compartment NA NA Rat Human +DTXSID6029626 Css NA 0.04546 mg/L 3compartmentss NA 50% Rat Human +DTXSID6029626 Css NA 0.2712 mg/L 3compartmentss NA 95% Rat Human +DTXSID6029626 Css NA 0.02916 mg/L PBTK NA 50% Rat Human +DTXSID6029626 Css NA 0.164 mg/L PBTK NA 95% Rat Human +DTXSID6029670 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029670 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6029670 Vd NA 3.351 L/kg 1compartment NA NA Human Human DTXSID6029670 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6029670 TK.Half.Life NA 5.208 hours 1compartment NA NA Human Human -DTXSID6029670 Css NA 0.05202 mg/L 3compartmentss NA 50% Human Human -DTXSID6029670 Css NA 0.4554 mg/L 3compartmentss NA 95% Human Human -DTXSID6029670 Css NA 0.07261 mg/L PBTK NA 50% Human Human -DTXSID6029670 Css NA 0.4701 mg/L PBTK NA 95% Human Human -DTXSID6029670 Clint NA 11.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029670 Fup NA 0.2379 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029670 Vd NA 4.439 L/kg 1compartment NA NA Rat Human +DTXSID6029670 TK.Half.Life NA 2.736 hours 1compartment NA NA Human Human +DTXSID6029670 Css NA 0.02852 mg/L 3compartmentss NA 50% Human Human +DTXSID6029670 Css NA 0.2679 mg/L 3compartmentss NA 95% Human Human +DTXSID6029670 Css NA 0.03414 mg/L PBTK NA 50% Human Human +DTXSID6029670 Css NA 0.2485 mg/L PBTK NA 95% Human Human +DTXSID6029670 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029670 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6029670 Vd NA 3.377 L/kg 1compartment NA NA Rat Human DTXSID6029670 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6029670 TK.Half.Life NA 3.031 hours 1compartment NA NA Rat Human -DTXSID6029670 Css NA 0.02702 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029670 Css NA 0.1813 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029670 Css NA 0.038 mg/L PBTK NA 50% Rat Human -DTXSID6029670 Css NA 0.1861 mg/L PBTK NA 95% Rat Human -DTXSID6029703 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029703 Fup NA 0.4914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029703 Vd NA 0.5114 L/kg 1compartment NA NA Human Human -DTXSID6029703 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6029703 TK.Half.Life NA 6.73 hours 1compartment NA NA Human Human -DTXSID6029703 Css NA 1.495 mg/L 3compartmentss NA 50% Human Human -DTXSID6029703 Css NA 7.56 mg/L 3compartmentss NA 95% Human Human -DTXSID6029703 Css NA 1.118 mg/L PBTK NA 50% Human Human -DTXSID6029703 Css NA 4.727 mg/L PBTK NA 95% Human Human -DTXSID6029703 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029703 Fup NA 0.4914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029703 Vd NA 0.5361 L/kg 1compartment NA NA Rat Human -DTXSID6029703 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6029703 TK.Half.Life NA 2.405 hours 1compartment NA NA Rat Human -DTXSID6029703 Css NA 0.4074 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029703 Css NA 1.782 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029703 Css NA 0.2902 mg/L PBTK NA 50% Rat Human -DTXSID6029703 Css NA 1.048 mg/L PBTK NA 95% Rat Human -DTXSID6029707 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029707 Fup NA 0.7706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029707 Vd NA 1.09 L/kg 1compartment NA NA Human Human -DTXSID6029707 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6029707 TK.Half.Life NA 9.516 hours 1compartment NA NA Human Human -DTXSID6029707 Css NA 0.9649 mg/L 3compartmentss NA 50% Human Human -DTXSID6029707 Css NA 6.299 mg/L 3compartmentss NA 95% Human Human -DTXSID6029707 Css NA 0.8514 mg/L PBTK NA 50% Human Human -DTXSID6029707 Css NA 4.19 mg/L PBTK NA 95% Human Human -DTXSID6029707 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029707 Fup NA 0.7706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029707 Vd NA 1.036 L/kg 1compartment NA NA Rat Human -DTXSID6029707 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6029707 TK.Half.Life NA 2.992 hours 1compartment NA NA Rat Human -DTXSID6029707 Css NA 0.2478 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029707 Css NA 1.629 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029707 Css NA 0.2121 mg/L PBTK NA 50% Rat Human -DTXSID6029707 Css NA 0.9898 mg/L PBTK NA 95% Rat Human -DTXSID6029755 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029755 Fup NA 0.6808 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6029755 Vd NA 1.19 L/kg 1compartment NA NA Human Human -DTXSID6029755 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6029755 TK.Half.Life NA 12.12 hours 1compartment NA NA Human Human -DTXSID6029755 Css NA 1.067 mg/L 3compartmentss NA 50% Human Human -DTXSID6029755 Css NA 7.131 mg/L 3compartmentss NA 95% Human Human -DTXSID6029755 Css NA 0.9354 mg/L PBTK NA 50% Human Human -DTXSID6029755 Css NA 4.667 mg/L PBTK NA 95% Human Human -DTXSID6029755 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029755 Fup NA 0.6808 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6029755 Vd NA 1.09 L/kg 1compartment NA NA Rat Human -DTXSID6029755 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6029755 TK.Half.Life NA 3.591 hours 1compartment NA NA Rat Human -DTXSID6029755 Css NA 0.278 mg/L 3compartmentss NA 50% Rat Human -DTXSID6029755 Css NA 1.85 mg/L 3compartmentss NA 95% Rat Human -DTXSID6029755 Css NA 0.2364 mg/L PBTK NA 50% Rat Human -DTXSID6029755 Css NA 1.12 mg/L PBTK NA 95% Rat Human -DTXSID6031209 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6031209 Fup NA 0.8232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6031209 Vd NA 0.9444 L/kg 1compartment NA NA Human Human -DTXSID6031209 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6031209 TK.Half.Life NA 7.535 hours 1compartment NA NA Human Human -DTXSID6031209 Css NA 0.9348 mg/L 3compartmentss NA 50% Human Human -DTXSID6031209 Css NA 5.74 mg/L 3compartmentss NA 95% Human Human -DTXSID6031209 Css NA 0.8084 mg/L PBTK NA 50% Human Human -DTXSID6031209 Css NA 3.769 mg/L PBTK NA 95% Human Human -DTXSID6031209 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6031209 Fup NA 0.8232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6031209 Vd NA 0.9341 L/kg 1compartment NA NA Rat Human -DTXSID6031209 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6031209 TK.Half.Life NA 2.51 hours 1compartment NA NA Rat Human -DTXSID6031209 Css NA 0.2376 mg/L 3compartmentss NA 50% Rat Human -DTXSID6031209 Css NA 1.435 mg/L 3compartmentss NA 95% Rat Human -DTXSID6031209 Css NA 0.2001 mg/L PBTK NA 50% Rat Human -DTXSID6031209 Css NA 0.8742 mg/L PBTK NA 95% Rat Human +DTXSID6029670 TK.Half.Life NA 1.513 hours 1compartment NA NA Rat Human +DTXSID6029670 Css NA 0.003326 mg/L 3compartmentss NA 50% Rat Human +DTXSID6029670 Css NA 0.02512 mg/L 3compartmentss NA 95% Rat Human +DTXSID6029670 Css NA 0.004288 mg/L PBTK NA 50% Rat Human +DTXSID6029670 Css NA 0.02311 mg/L PBTK NA 95% Rat Human +DTXSID60310238 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60310238 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60310238 Vd NA 1.648 L/kg 1compartment NA NA Human Human +DTXSID60310238 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60310238 TK.Half.Life NA 2.036 hours 1compartment NA NA Human Human +DTXSID60310238 Css NA 0.06054 mg/L 3compartmentss NA 50% Human Human +DTXSID60310238 Css NA 0.4767 mg/L 3compartmentss NA 95% Human Human +DTXSID60310238 Css NA 0.0485 mg/L PBTK NA 50% Human Human +DTXSID60310238 Css NA 0.3369 mg/L PBTK NA 95% Human Human +DTXSID60310238 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60310238 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60310238 Vd NA 1.392 L/kg 1compartment NA NA Rat Human +DTXSID60310238 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60310238 TK.Half.Life NA 0.8426 hours 1compartment NA NA Rat Human +DTXSID60310238 Css NA 0.007015 mg/L 3compartmentss NA 50% Rat Human +DTXSID60310238 Css NA 0.04115 mg/L 3compartmentss NA 95% Rat Human +DTXSID60310238 Css NA 0.005649 mg/L PBTK NA 50% Rat Human +DTXSID60310238 Css NA 0.02865 mg/L PBTK NA 95% Rat Human +DTXSID60311265 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60311265 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60311265 Vd NA 1.495 L/kg 1compartment NA NA Human Human +DTXSID60311265 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60311265 TK.Half.Life NA 2.35 hours 1compartment NA NA Human Human +DTXSID60311265 Css NA 0.09715 mg/L 3compartmentss NA 50% Human Human +DTXSID60311265 Css NA 0.6851 mg/L 3compartmentss NA 95% Human Human +DTXSID60311265 Css NA 0.07136 mg/L PBTK NA 50% Human Human +DTXSID60311265 Css NA 0.4634 mg/L PBTK NA 95% Human Human +DTXSID60311265 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60311265 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60311265 Vd NA 1.2 L/kg 1compartment NA NA Rat Human +DTXSID60311265 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60311265 TK.Half.Life NA 0.9352 hours 1compartment NA NA Rat Human +DTXSID60311265 Css NA 0.01088 mg/L 3compartmentss NA 50% Rat Human +DTXSID60311265 Css NA 0.05679 mg/L 3compartmentss NA 95% Rat Human +DTXSID60311265 Css NA 0.008034 mg/L PBTK NA 50% Rat Human +DTXSID60311265 Css NA 0.03802 mg/L PBTK NA 95% Rat Human DTXSID6031380 Clint NA 1.085 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6031380 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6031380 Vd NA 0.4926 L/kg 1compartment NA NA Human Human +DTXSID6031380 Vd NA 0.4853 L/kg 1compartment NA NA Human Human DTXSID6031380 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6031380 TK.Half.Life NA 1.247 hours 1compartment NA NA Human Human -DTXSID6031380 Css NA 0.3296 mg/L 3compartmentss NA 50% Human Human -DTXSID6031380 Css NA 2.119 mg/L 3compartmentss NA 95% Human Human -DTXSID6031380 Css NA 0.2449 mg/L PBTK NA 50% Human Human -DTXSID6031380 Css NA 1.332 mg/L PBTK NA 95% Human Human +DTXSID6031380 TK.Half.Life NA 1.22 hours 1compartment NA NA Human Human +DTXSID6031380 Css NA 0.169 mg/L 3compartmentss NA 50% Human Human +DTXSID6031380 Css NA 1.167 mg/L 3compartmentss NA 95% Human Human +DTXSID6031380 Css NA 0.1252 mg/L PBTK NA 50% Human Human +DTXSID6031380 Css NA 0.7505 mg/L PBTK NA 95% Human Human DTXSID6031380 Clint NA 1.085 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6031380 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6031380 Vd NA 0.5204 L/kg 1compartment NA NA Rat Human +DTXSID6031380 Vd NA 0.5141 L/kg 1compartment NA NA Rat Human DTXSID6031380 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6031380 TK.Half.Life NA 0.6353 hours 1compartment NA NA Rat Human -DTXSID6031380 Css NA 0.1262 mg/L 3compartmentss NA 50% Rat Human -DTXSID6031380 Css NA 0.714 mg/L 3compartmentss NA 95% Rat Human -DTXSID6031380 Css NA 0.09165 mg/L PBTK NA 50% Rat Human -DTXSID6031380 Css NA 0.4208 mg/L PBTK NA 95% Rat Human -DTXSID6032061 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032061 Fup NA 0.6349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032061 Vd NA 0.59 L/kg 1compartment NA NA Human Human -DTXSID6032061 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6032061 TK.Half.Life NA 6.012 hours 1compartment NA NA Human Human -DTXSID6032061 Css NA 1.201 mg/L 3compartmentss NA 50% Human Human -DTXSID6032061 Css NA 7.815 mg/L 3compartmentss NA 95% Human Human -DTXSID6032061 Css NA 0.9425 mg/L PBTK NA 50% Human Human -DTXSID6032061 Css NA 4.887 mg/L PBTK NA 95% Human Human -DTXSID6032061 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032061 Fup NA 0.6349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032061 Vd NA 0.6188 L/kg 1compartment NA NA Rat Human -DTXSID6032061 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6032061 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human -DTXSID6032061 Css NA 0.3182 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032061 Css NA 1.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032061 Css NA 0.2388 mg/L PBTK NA 50% Rat Human -DTXSID6032061 Css NA 1.082 mg/L PBTK NA 95% Rat Human -DTXSID6032192 Clint NA 93.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032192 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032192 Vd NA 2.823 L/kg 1compartment NA NA Human Human -DTXSID6032192 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6032192 TK.Half.Life NA 18.24 hours 1compartment NA NA Human Human -DTXSID6032192 Css NA 0.7966 mg/L 3compartmentss NA 50% Human Human -DTXSID6032192 Css NA 5.454 mg/L 3compartmentss NA 95% Human Human -DTXSID6032192 Css NA 0.536 mg/L PBTK NA 50% Human Human -DTXSID6032192 Css NA 3.52 mg/L PBTK NA 95% Human Human -DTXSID6032192 Clint NA 93.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032192 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032192 Vd NA 2.108 L/kg 1compartment NA NA Rat Human -DTXSID6032192 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6032192 TK.Half.Life NA 3.705 hours 1compartment NA NA Rat Human -DTXSID6032192 Css NA 0.4494 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032192 Css NA 2.596 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032192 Css NA 0.2861 mg/L PBTK NA 50% Rat Human -DTXSID6032192 Css NA 1.599 mg/L PBTK NA 95% Rat Human +DTXSID6031380 TK.Half.Life NA 0.6239 hours 1compartment NA NA Rat Human +DTXSID6031380 Css NA 0.001254 mg/L 3compartmentss NA 50% Rat Human +DTXSID6031380 Css NA 0.009513 mg/L 3compartmentss NA 95% Rat Human +DTXSID6031380 Css NA 0.0009067 mg/L PBTK NA 50% Rat Human +DTXSID6031380 Css NA 0.005777 mg/L PBTK NA 95% Rat Human +DTXSID6032192 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032192 Fup 0.00455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032192 Vd NA 4.909 L/kg 1compartment NA NA Human Human +DTXSID6032192 Days.Css NA 27 Days PBTK NA NA Human Human +DTXSID6032192 TK.Half.Life NA 150.7 hours 1compartment NA NA Human Human +DTXSID6032192 Css NA 2.663 mg/L 3compartmentss NA 50% Human Human +DTXSID6032192 Css NA 16.1 mg/L 3compartmentss NA 95% Human Human +DTXSID6032192 Css NA 2.129 mg/L PBTK NA 50% Human Human +DTXSID6032192 Css NA 12.67 mg/L PBTK NA 95% Human Human +DTXSID6032192 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032192 Fup 0.00455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032192 Vd NA 3.746 L/kg 1compartment NA NA Rat Human +DTXSID6032192 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID6032192 TK.Half.Life NA 21.71 hours 1compartment NA NA Rat Human +DTXSID6032192 Css NA 0.1334 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032192 Css NA 0.7824 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032192 Css NA 0.107 mg/L PBTK NA 50% Rat Human +DTXSID6032192 Css NA 0.616 mg/L PBTK NA 95% Rat Human DTXSID6032352 Clint 24.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6032352 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032352 Vd NA 2.545 L/kg 1compartment NA NA Human Human +DTXSID6032352 Fup 0.0222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032352 Vd NA 2.654 L/kg 1compartment NA NA Human Human DTXSID6032352 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6032352 TK.Half.Life NA 31.82 hours 1compartment NA NA Human Human -DTXSID6032352 Css NA 1.757 mg/L 3compartmentss NA 50% Human Human -DTXSID6032352 Css NA 12.92 mg/L 3compartmentss NA 95% Human Human -DTXSID6032352 Css NA 1.163 mg/L PBTK NA 50% Human Human -DTXSID6032352 Css NA 8.418 mg/L PBTK NA 95% Human Human +DTXSID6032352 TK.Half.Life NA 31.25 hours 1compartment NA NA Human Human +DTXSID6032352 Css NA 1.584 mg/L 3compartmentss NA 50% Human Human +DTXSID6032352 Css NA 11.37 mg/L 3compartmentss NA 95% Human Human +DTXSID6032352 Css NA 1.056 mg/L PBTK NA 50% Human Human +DTXSID6032352 Css NA 7.281 mg/L PBTK NA 95% Human Human DTXSID6032352 Clint 24.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6032352 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032352 Vd NA 1.899 L/kg 1compartment NA NA Rat Human +DTXSID6032352 Fup 0.0222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032352 Vd NA 1.982 L/kg 1compartment NA NA Rat Human DTXSID6032352 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6032352 TK.Half.Life NA 7.64 hours 1compartment NA NA Rat Human -DTXSID6032352 Css NA 0.9796 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032352 Css NA 5.738 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032352 Css NA 0.6173 mg/L PBTK NA 50% Rat Human -DTXSID6032352 Css NA 3.459 mg/L PBTK NA 95% Rat Human +DTXSID6032352 TK.Half.Life NA 6.974 hours 1compartment NA NA Rat Human +DTXSID6032352 Css NA 0.2025 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032352 Css NA 1.184 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032352 Css NA 0.1333 mg/L PBTK NA 50% Rat Human +DTXSID6032352 Css NA 0.7547 mg/L PBTK NA 95% Rat Human DTXSID6032354 Clint 1010 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6032354 Fup 0.0148 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6032354 Vd NA 0.2645 L/kg 1compartment NA NA Human Human DTXSID6032354 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6032354 TK.Half.Life NA 0.3203 hours 1compartment NA NA Human Human -DTXSID6032354 Css NA 0.0339 mg/L 3compartmentss NA 50% Human Human -DTXSID6032354 Css NA 0.2734 mg/L 3compartmentss NA 95% Human Human -DTXSID6032354 Css NA 0.02044 mg/L PBTK NA 50% Human Human -DTXSID6032354 Css NA 0.1644 mg/L PBTK NA 95% Human Human +DTXSID6032354 Css NA 0.03027 mg/L 3compartmentss NA 50% Human Human +DTXSID6032354 Css NA 0.275 mg/L 3compartmentss NA 95% Human Human +DTXSID6032354 Css NA 0.01835 mg/L PBTK NA 50% Human Human +DTXSID6032354 Css NA 0.1624 mg/L PBTK NA 95% Human Human DTXSID6032354 Clint 1010 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6032354 Fup 0.0148 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6032354 Vd NA 0.2531 L/kg 1compartment NA NA Rat Human DTXSID6032354 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6032354 TK.Half.Life NA 0.1715 hours 1compartment NA NA Rat Human -DTXSID6032354 Css NA 0.02854 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032354 Css NA 0.1885 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032354 Css NA 0.01616 mg/L PBTK NA 50% Rat Human -DTXSID6032354 Css NA 0.105 mg/L PBTK NA 95% Rat Human +DTXSID6032354 Css NA 0.006173 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032354 Css NA 0.04488 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032354 Css NA 0.003616 mg/L PBTK NA 50% Rat Human +DTXSID6032354 Css NA 0.02569 mg/L PBTK NA 95% Rat Human DTXSID6032356 Clint 34.48 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID6032356 Fup NA 0.1493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032356 Vd NA 2.968 L/kg 1compartment NA NA Human Human -DTXSID6032356 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6032356 TK.Half.Life NA 13.52 hours 1compartment NA NA Human Human -DTXSID6032356 Css NA 0.4826 mg/L 3compartmentss NA 50% Human Human -DTXSID6032356 Css NA 3.022 mg/L 3compartmentss NA 95% Human Human -DTXSID6032356 Css NA 0.3402 mg/L PBTK NA 50% Human Human -DTXSID6032356 Css NA 2.061 mg/L PBTK NA 95% Human Human +DTXSID6032356 Fup 0.0261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032356 Vd NA 2.303 L/kg 1compartment NA NA Human Human +DTXSID6032356 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6032356 TK.Half.Life NA 14.71 hours 1compartment NA NA Human Human +DTXSID6032356 Css NA 0.862 mg/L 3compartmentss NA 50% Human Human +DTXSID6032356 Css NA 6.777 mg/L 3compartmentss NA 95% Human Human +DTXSID6032356 Css NA 0.5643 mg/L PBTK NA 50% Human Human +DTXSID6032356 Css NA 4.238 mg/L PBTK NA 95% Human Human DTXSID6032356 Clint 34.48 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID6032356 Fup NA 0.1493 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032356 Vd NA 2.235 L/kg 1compartment NA NA Rat Human +DTXSID6032356 Fup 0.0261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032356 Vd NA 1.719 L/kg 1compartment NA NA Rat Human DTXSID6032356 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6032356 TK.Half.Life NA 2.597 hours 1compartment NA NA Rat Human -DTXSID6032356 Css NA 0.2645 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032356 Css NA 1.356 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032356 Css NA 0.179 mg/L PBTK NA 50% Rat Human -DTXSID6032356 Css NA 0.8824 mg/L PBTK NA 95% Rat Human +DTXSID6032356 TK.Half.Life NA 4.166 hours 1compartment NA NA Rat Human +DTXSID6032356 Css NA 0.1114 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032356 Css NA 0.7189 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032356 Css NA 0.07187 mg/L PBTK NA 50% Rat Human +DTXSID6032356 Css NA 0.4456 mg/L PBTK NA 95% Rat Human DTXSID6032358 Clint 32.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6032358 Fup 0.437 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6032358 Vd NA 0.4346 L/kg 1compartment NA NA Human Human DTXSID6032358 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6032358 TK.Half.Life NA 0.4365 hours 1compartment NA NA Human Human -DTXSID6032358 Css NA 0.03177 mg/L 3compartmentss NA 50% Human Human -DTXSID6032358 Css NA 0.408 mg/L 3compartmentss NA 95% Human Human -DTXSID6032358 Css NA 0.02244 mg/L PBTK NA 50% Human Human -DTXSID6032358 Css NA 0.2861 mg/L PBTK NA 95% Human Human +DTXSID6032358 Css NA 0.02864 mg/L 3compartmentss NA 50% Human Human +DTXSID6032358 Css NA 0.3966 mg/L 3compartmentss NA 95% Human Human +DTXSID6032358 Css NA 0.02012 mg/L PBTK NA 50% Human Human +DTXSID6032358 Css NA 0.2747 mg/L PBTK NA 95% Human Human DTXSID6032358 Clint 32.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6032358 Fup 0.437 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6032358 Vd NA 0.4364 L/kg 1compartment NA NA Rat Human DTXSID6032358 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6032358 TK.Half.Life NA 0.2145 hours 1compartment NA NA Rat Human -DTXSID6032358 Css NA 0.01702 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032358 Css NA 0.1691 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032358 Css NA 0.01167 mg/L PBTK NA 50% Rat Human -DTXSID6032358 Css NA 0.1131 mg/L PBTK NA 95% Rat Human -DTXSID6032431 Clint NA 14.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032431 Fup NA 0.0614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032431 Vd NA 1.747 L/kg 1compartment NA NA Human Human +DTXSID6032358 Css NA 0.003672 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032358 Css NA 0.03802 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032358 Css NA 0.00259 mg/L PBTK NA 50% Rat Human +DTXSID6032358 Css NA 0.02614 mg/L PBTK NA 95% Rat Human +DTXSID6032431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032431 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032431 Vd NA 2.403 L/kg 1compartment NA NA Human Human DTXSID6032431 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6032431 TK.Half.Life NA 10.28 hours 1compartment NA NA Human Human -DTXSID6032431 Css NA 0.8262 mg/L 3compartmentss NA 50% Human Human -DTXSID6032431 Css NA 5.979 mg/L 3compartmentss NA 95% Human Human -DTXSID6032431 Css NA 0.5376 mg/L PBTK NA 50% Human Human -DTXSID6032431 Css NA 3.753 mg/L PBTK NA 95% Human Human -DTXSID6032431 Clint NA 14.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032431 Fup NA 0.0614 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032431 Vd NA 1.315 L/kg 1compartment NA NA Rat Human +DTXSID6032431 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human +DTXSID6032431 Css NA 0.2636 mg/L 3compartmentss NA 50% Human Human +DTXSID6032431 Css NA 1.614 mg/L 3compartmentss NA 95% Human Human +DTXSID6032431 Css NA 0.1881 mg/L PBTK NA 50% Human Human +DTXSID6032431 Css NA 1.116 mg/L PBTK NA 95% Human Human +DTXSID6032431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032431 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032431 Vd NA 1.827 L/kg 1compartment NA NA Rat Human DTXSID6032431 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6032431 TK.Half.Life NA 3.673 hours 1compartment NA NA Rat Human -DTXSID6032431 Css NA 0.4596 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032431 Css NA 2.422 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032431 Css NA 0.2822 mg/L PBTK NA 50% Rat Human -DTXSID6032431 Css NA 1.431 mg/L PBTK NA 95% Rat Human -DTXSID6032437 Clint NA 48.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032437 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032437 Vd NA 0.177 L/kg 1compartment NA NA Human Human -DTXSID6032437 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6032437 TK.Half.Life NA 2.748 hours 1compartment NA NA Human Human -DTXSID6032437 Css NA 2.806 mg/L 3compartmentss NA 50% Human Human -DTXSID6032437 Css NA 28.59 mg/L 3compartmentss NA 95% Human Human -DTXSID6032437 Css NA 1.636 mg/L PBTK NA 50% Human Human -DTXSID6032437 Css NA 16.65 mg/L PBTK NA 95% Human Human -DTXSID6032437 Clint NA 48.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032437 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032437 Vd NA 0.1727 L/kg 1compartment NA NA Rat Human -DTXSID6032437 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6032437 TK.Half.Life NA 1.815 hours 1compartment NA NA Rat Human -DTXSID6032437 Css NA 1.654 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032437 Css NA 13.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032437 Css NA 0.8984 mg/L PBTK NA 50% Rat Human -DTXSID6032437 Css NA 7.207 mg/L PBTK NA 95% Rat Human -DTXSID6032514 Clint NA 3.976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032514 Fup NA 0.7733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032514 Vd NA 1.158 L/kg 1compartment NA NA Human Human +DTXSID6032431 TK.Half.Life NA 1.979 hours 1compartment NA NA Rat Human +DTXSID6032431 Css NA 0.03319 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032431 Css NA 0.1626 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032431 Css NA 0.02348 mg/L PBTK NA 50% Rat Human +DTXSID6032431 Css NA 0.1129 mg/L PBTK NA 95% Rat Human +DTXSID6032514 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032514 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032514 Vd NA 0.5949 L/kg 1compartment NA NA Human Human DTXSID6032514 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6032514 TK.Half.Life NA 1.823 hours 1compartment NA NA Human Human -DTXSID6032514 Css NA 0.1335 mg/L 3compartmentss NA 50% Human Human -DTXSID6032514 Css NA 1.09 mg/L 3compartmentss NA 95% Human Human -DTXSID6032514 Css NA 0.1173 mg/L PBTK NA 50% Human Human -DTXSID6032514 Css NA 0.7638 mg/L PBTK NA 95% Human Human -DTXSID6032514 Clint NA 3.976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032514 Fup NA 0.7733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032514 Vd NA 1.087 L/kg 1compartment NA NA Rat Human +DTXSID6032514 TK.Half.Life NA 0.7889 hours 1compartment NA NA Human Human +DTXSID6032514 Css NA 0.06996 mg/L 3compartmentss NA 50% Human Human +DTXSID6032514 Css NA 0.5103 mg/L 3compartmentss NA 95% Human Human +DTXSID6032514 Css NA 0.04943 mg/L PBTK NA 50% Human Human +DTXSID6032514 Css NA 0.3325 mg/L PBTK NA 95% Human Human +DTXSID6032514 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032514 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032514 Vd NA 0.5673 L/kg 1compartment NA NA Rat Human DTXSID6032514 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6032514 TK.Half.Life NA 0.8953 hours 1compartment NA NA Rat Human -DTXSID6032514 Css NA 0.06132 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032514 Css NA 0.4452 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032514 Css NA 0.05297 mg/L PBTK NA 50% Rat Human -DTXSID6032514 Css NA 0.2813 mg/L PBTK NA 95% Rat Human -DTXSID6032516 Clint NA 51.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032516 Fup NA 0.1373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032516 Vd NA 2.798 L/kg 1compartment NA NA Human Human +DTXSID6032514 TK.Half.Life NA 0.3988 hours 1compartment NA NA Rat Human +DTXSID6032514 Css NA 0.008744 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032514 Css NA 0.04921 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032514 Css NA 0.006146 mg/L PBTK NA 50% Rat Human +DTXSID6032514 Css NA 0.03246 mg/L PBTK NA 95% Rat Human +DTXSID6032516 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032516 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032516 Vd NA 2.768 L/kg 1compartment NA NA Human Human DTXSID6032516 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6032516 TK.Half.Life NA 7.21 hours 1compartment NA NA Human Human -DTXSID6032516 Css NA 0.2346 mg/L 3compartmentss NA 50% Human Human -DTXSID6032516 Css NA 1.591 mg/L 3compartmentss NA 95% Human Human -DTXSID6032516 Css NA 0.1648 mg/L PBTK NA 50% Human Human -DTXSID6032516 Css NA 1.065 mg/L PBTK NA 95% Human Human -DTXSID6032516 Clint NA 51.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032516 Fup NA 0.1373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032516 Vd NA 2.108 L/kg 1compartment NA NA Rat Human +DTXSID6032516 TK.Half.Life NA 13.86 hours 1compartment NA NA Human Human +DTXSID6032516 Css NA 0.541 mg/L 3compartmentss NA 50% Human Human +DTXSID6032516 Css NA 3.545 mg/L 3compartmentss NA 95% Human Human +DTXSID6032516 Css NA 0.3777 mg/L PBTK NA 50% Human Human +DTXSID6032516 Css NA 2.353 mg/L PBTK NA 95% Human Human +DTXSID6032516 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032516 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032516 Vd NA 2.087 L/kg 1compartment NA NA Rat Human DTXSID6032516 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6032516 TK.Half.Life NA 1.712 hours 1compartment NA NA Rat Human -DTXSID6032516 Css NA 0.1312 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032516 Css NA 0.7083 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032516 Css NA 0.08774 mg/L PBTK NA 50% Rat Human -DTXSID6032516 Css NA 0.4633 mg/L PBTK NA 95% Rat Human +DTXSID6032516 TK.Half.Life NA 3.056 hours 1compartment NA NA Rat Human +DTXSID6032516 Css NA 0.06959 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032516 Css NA 0.3632 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032516 Css NA 0.04803 mg/L PBTK NA 50% Rat Human +DTXSID6032516 Css NA 0.2443 mg/L PBTK NA 95% Rat Human +DTXSID6032518 Clint NA 0.2045 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6032518 Fup NA 0.3269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6032518 Vd NA 2.56 L/kg 1compartment NA NA Human Human +DTXSID6032518 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID6032518 TK.Half.Life NA 105 hours 1compartment NA NA Human Human +DTXSID6032518 Css NA 3.755 mg/L 3compartmentss NA 50% Human Human +DTXSID6032518 Css NA 11.88 mg/L 3compartmentss NA 95% Human Human +DTXSID6032518 Css NA 2.836 mg/L PBTK NA 50% Human Human +DTXSID6032518 Css NA 8.048 mg/L PBTK NA 95% Human Human +DTXSID6032518 Clint NA 0.2045 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6032518 Fup NA 0.3269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6032518 Vd NA 1.97 L/kg 1compartment NA NA Rat Human +DTXSID6032518 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID6032518 TK.Half.Life NA 16.16 hours 1compartment NA NA Rat Human +DTXSID6032518 Css NA 0.07797 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032518 Css NA 0.3896 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032518 Css NA 0.05746 mg/L PBTK NA 50% Rat Human +DTXSID6032518 Css NA 0.2693 mg/L PBTK NA 95% Rat Human DTXSID6032562 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID6032562 Fup NA 0.0777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032562 Vd NA 2.624 L/kg 1compartment NA NA Human Human -DTXSID6032562 Days.Css NA 188 Days PBTK NA NA Human Human -DTXSID6032562 TK.Half.Life NA 756.3 hours 1compartment NA NA Human Human -DTXSID6032562 Css NA 36.55 mg/L 3compartmentss NA 50% Human Human -DTXSID6032562 Css NA 113.1 mg/L 3compartmentss NA 95% Human Human -DTXSID6032562 Css NA 25.36 mg/L PBTK NA 50% Human Human -DTXSID6032562 Css NA 71.97 mg/L PBTK NA 95% Human Human +DTXSID6032562 Fup 0.0378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032562 Vd NA 2.207 L/kg 1compartment NA NA Human Human +DTXSID6032562 Days.Css NA 209 Days PBTK NA NA Human Human +DTXSID6032562 TK.Half.Life NA 830 hours 1compartment NA NA Human Human +DTXSID6032562 Css NA 52.58 mg/L 3compartmentss NA 50% Human Human +DTXSID6032562 Css NA 212.2 mg/L 3compartmentss NA 95% Human Human +DTXSID6032562 Css NA 34.8 mg/L PBTK NA 50% Human Human +DTXSID6032562 Css NA 130.2 mg/L PBTK NA 95% Human Human DTXSID6032562 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID6032562 Fup NA 0.0777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032562 Vd NA 1.995 L/kg 1compartment NA NA Rat Human -DTXSID6032562 Days.Css NA 46 Days PBTK NA NA Rat Human -DTXSID6032562 TK.Half.Life NA 89.8 hours 1compartment NA NA Rat Human -DTXSID6032562 Css NA 9.955 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032562 Css NA 25.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032562 Css NA 6.57 mg/L PBTK NA 50% Rat Human -DTXSID6032562 Css NA 15.27 mg/L PBTK NA 95% Rat Human +DTXSID6032562 Fup 0.0378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032562 Vd NA 1.667 L/kg 1compartment NA NA Rat Human +DTXSID6032562 Days.Css NA 51 Days PBTK NA NA Rat Human +DTXSID6032562 TK.Half.Life NA 125 hours 1compartment NA NA Rat Human +DTXSID6032562 Css NA 3.33 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032562 Css NA 11.24 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032562 Css NA 2.157 mg/L PBTK NA 50% Rat Human +DTXSID6032562 Css NA 6.61 mg/L PBTK NA 95% Rat Human DTXSID6032641 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6032641 Fup 0.02799 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID6032641 Vd NA 0.2247 L/kg 1compartment NA NA Human Human -DTXSID6032641 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID6032641 TK.Half.Life NA 51.96 hours 1compartment NA NA Human Human -DTXSID6032641 Css NA 39.37 mg/L 3compartmentss NA 50% Human Human -DTXSID6032641 Css NA 242 mg/L 3compartmentss NA 95% Human Human -DTXSID6032641 Css NA 23.54 mg/L PBTK NA 50% Human Human -DTXSID6032641 Css NA 139.8 mg/L PBTK NA 95% Human Human +DTXSID6032641 Vd NA 0.2507 L/kg 1compartment NA NA Human Human +DTXSID6032641 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID6032641 TK.Half.Life NA 57.96 hours 1compartment NA NA Human Human +DTXSID6032641 Css NA 35.22 mg/L 3compartmentss NA 50% Human Human +DTXSID6032641 Css NA 222.1 mg/L 3compartmentss NA 95% Human Human +DTXSID6032641 Css NA 21.16 mg/L PBTK NA 50% Human Human +DTXSID6032641 Css NA 127.8 mg/L PBTK NA 95% Human Human DTXSID6032641 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6032641 Fup 0.02799 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID6032641 Vd NA 0.2187 L/kg 1compartment NA NA Rat Human +DTXSID6032641 Vd NA 0.2453 L/kg 1compartment NA NA Rat Human DTXSID6032641 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6032641 TK.Half.Life NA 17.23 hours 1compartment NA NA Rat Human -DTXSID6032641 Css NA 11.28 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032641 Css NA 59.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032641 Css NA 6.266 mg/L PBTK NA 50% Rat Human -DTXSID6032641 Css NA 32.22 mg/L PBTK NA 95% Rat Human +DTXSID6032641 TK.Half.Life NA 19.32 hours 1compartment NA NA Rat Human +DTXSID6032641 Css NA 1.092 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032641 Css NA 7.347 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032641 Css NA 0.629 mg/L PBTK NA 50% Rat Human +DTXSID6032641 Css NA 4.122 mg/L PBTK NA 95% Rat Human DTXSID6032645 Clint 5.715 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6032645 Fup 0.9933 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6032645 Vd NA 0.6798 L/kg 1compartment NA NA Human Human DTXSID6032645 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6032645 TK.Half.Life NA 0.7417 hours 1compartment NA NA Human Human -DTXSID6032645 Css NA 0.08764 mg/L 3compartmentss NA 50% Human Human -DTXSID6032645 Css NA 0.6994 mg/L 3compartmentss NA 95% Human Human -DTXSID6032645 Css NA 0.07073 mg/L PBTK NA 50% Human Human -DTXSID6032645 Css NA 0.4978 mg/L PBTK NA 95% Human Human +DTXSID6032645 Css NA 0.0852 mg/L 3compartmentss NA 50% Human Human +DTXSID6032645 Css NA 0.6872 mg/L 3compartmentss NA 95% Human Human +DTXSID6032645 Css NA 0.06876 mg/L PBTK NA 50% Human Human +DTXSID6032645 Css NA 0.483 mg/L PBTK NA 95% Human Human DTXSID6032645 Clint 5.715 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6032645 Fup 0.9933 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID6032645 Vd NA 0.6907 L/kg 1compartment NA NA Rat Human DTXSID6032645 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6032645 TK.Half.Life NA 0.3892 hours 1compartment NA NA Rat Human -DTXSID6032645 Css NA 0.04191 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032645 Css NA 0.2855 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032645 Css NA 0.0334 mg/L PBTK NA 50% Rat Human -DTXSID6032645 Css NA 0.1776 mg/L PBTK NA 95% Rat Human +DTXSID6032645 Css NA 0.009341 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032645 Css NA 0.06649 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032645 Css NA 0.007698 mg/L PBTK NA 50% Rat Human +DTXSID6032645 Css NA 0.04307 mg/L PBTK NA 95% Rat Human DTXSID6032647 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6032647 Fup 0.331 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6032647 Vd NA 2.875 L/kg 1compartment NA NA Human Human DTXSID6032647 Days.Css NA 73 Days PBTK NA NA Human Human DTXSID6032647 TK.Half.Life NA 327.1 hours 1compartment NA NA Human Human -DTXSID6032647 Css NA 0.07213 mg/L 3compartmentss NA 50% Human Human -DTXSID6032647 Css NA 0.8044 mg/L 3compartmentss NA 95% Human Human -DTXSID6032647 Css NA 0.05357 mg/L PBTK NA 50% Human Human -DTXSID6032647 Css NA 0.5838 mg/L PBTK NA 95% Human Human +DTXSID6032647 Css NA 0.06894 mg/L 3compartmentss NA 50% Human Human +DTXSID6032647 Css NA 0.8038 mg/L 3compartmentss NA 95% Human Human +DTXSID6032647 Css NA 0.05172 mg/L PBTK NA 50% Human Human +DTXSID6032647 Css NA 0.5716 mg/L PBTK NA 95% Human Human DTXSID6032647 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6032647 Fup 0.331 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6032647 Vd NA 2.187 L/kg 1compartment NA NA Rat Human DTXSID6032647 Days.Css NA 17 Days PBTK NA NA Rat Human DTXSID6032647 TK.Half.Life NA 31.31 hours 1compartment NA NA Rat Human -DTXSID6032647 Css NA 0.04108 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032647 Css NA 0.3322 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032647 Css NA 0.02924 mg/L PBTK NA 50% Rat Human -DTXSID6032647 Css NA 0.2288 mg/L PBTK NA 95% Rat Human +DTXSID6032647 Css NA 0.009404 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032647 Css NA 0.07372 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032647 Css NA 0.006952 mg/L PBTK NA 50% Rat Human +DTXSID6032647 Css NA 0.05082 mg/L PBTK NA 95% Rat Human DTXSID6032649 Clint 37.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID6032649 Fup NA 0.057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032649 Vd NA 3.057 L/kg 1compartment NA NA Human Human +DTXSID6032649 Fup 0.0166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6032649 Vd NA 2.864 L/kg 1compartment NA NA Human Human DTXSID6032649 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6032649 TK.Half.Life NA 29.72 hours 1compartment NA NA Human Human -DTXSID6032649 Css NA 1.133 mg/L 3compartmentss NA 50% Human Human -DTXSID6032649 Css NA 7.201 mg/L 3compartmentss NA 95% Human Human -DTXSID6032649 Css NA 0.7863 mg/L PBTK NA 50% Human Human -DTXSID6032649 Css NA 4.814 mg/L PBTK NA 95% Human Human +DTXSID6032649 TK.Half.Life NA 30.56 hours 1compartment NA NA Human Human +DTXSID6032649 Css NA 1.344 mg/L 3compartmentss NA 50% Human Human +DTXSID6032649 Css NA 9.624 mg/L 3compartmentss NA 95% Human Human +DTXSID6032649 Css NA 0.9055 mg/L PBTK NA 50% Human Human +DTXSID6032649 Css NA 6.262 mg/L PBTK NA 95% Human Human DTXSID6032649 Clint 37.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID6032649 Fup NA 0.057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032649 Vd NA 2.292 L/kg 1compartment NA NA Rat Human +DTXSID6032649 Fup 0.0166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6032649 Vd NA 2.14 L/kg 1compartment NA NA Rat Human DTXSID6032649 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6032649 TK.Half.Life NA 4.687 hours 1compartment NA NA Rat Human -DTXSID6032649 Css NA 0.6359 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032649 Css NA 3.378 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032649 Css NA 0.4218 mg/L PBTK NA 50% Rat Human -DTXSID6032649 Css NA 2.195 mg/L PBTK NA 95% Rat Human +DTXSID6032649 TK.Half.Life NA 5.791 hours 1compartment NA NA Rat Human +DTXSID6032649 Css NA 0.1735 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032649 Css NA 1.068 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032649 Css NA 0.1163 mg/L PBTK NA 50% Rat Human +DTXSID6032649 Css NA 0.6843 mg/L PBTK NA 95% Rat Human DTXSID6032722 Clint NA 0.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6032722 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6032722 Vd NA 0.8377 L/kg 1compartment NA NA Human Human +DTXSID6032722 Vd NA 0.8837 L/kg 1compartment NA NA Human Human DTXSID6032722 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6032722 TK.Half.Life NA 2.276 hours 1compartment NA NA Human Human -DTXSID6032722 Css NA 0.3204 mg/L 3compartmentss NA 50% Human Human -DTXSID6032722 Css NA 2.342 mg/L 3compartmentss NA 95% Human Human -DTXSID6032722 Css NA 0.2726 mg/L PBTK NA 50% Human Human -DTXSID6032722 Css NA 1.521 mg/L PBTK NA 95% Human Human +DTXSID6032722 TK.Half.Life NA 2.401 hours 1compartment NA NA Human Human +DTXSID6032722 Css NA 0.2621 mg/L 3compartmentss NA 50% Human Human +DTXSID6032722 Css NA 1.868 mg/L 3compartmentss NA 95% Human Human +DTXSID6032722 Css NA 0.2266 mg/L PBTK NA 50% Human Human +DTXSID6032722 Css NA 1.251 mg/L PBTK NA 95% Human Human DTXSID6032722 Clint NA 0.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6032722 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6032722 Vd NA 0.8667 L/kg 1compartment NA NA Rat Human +DTXSID6032722 Vd NA 0.907 L/kg 1compartment NA NA Rat Human DTXSID6032722 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6032722 TK.Half.Life NA 1.121 hours 1compartment NA NA Rat Human -DTXSID6032722 Css NA 0.1178 mg/L 3compartmentss NA 50% Rat Human -DTXSID6032722 Css NA 0.7471 mg/L 3compartmentss NA 95% Rat Human -DTXSID6032722 Css NA 0.09908 mg/L PBTK NA 50% Rat Human -DTXSID6032722 Css NA 0.4565 mg/L PBTK NA 95% Rat Human -DTXSID6033247 Clint NA 2.625 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033247 Fup NA 0.3849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033247 Vd NA 1.681 L/kg 1compartment NA NA Human Human +DTXSID6032722 TK.Half.Life NA 1.172 hours 1compartment NA NA Rat Human +DTXSID6032722 Css NA 0.006785 mg/L 3compartmentss NA 50% Rat Human +DTXSID6032722 Css NA 0.06139 mg/L 3compartmentss NA 95% Rat Human +DTXSID6032722 Css NA 0.005744 mg/L PBTK NA 50% Rat Human +DTXSID6032722 Css NA 0.03934 mg/L PBTK NA 95% Rat Human +DTXSID6033241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033241 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033241 Vd NA 1.17 L/kg 1compartment NA NA Human Human +DTXSID6033241 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6033241 TK.Half.Life NA 1.854 hours 1compartment NA NA Human Human +DTXSID6033241 Css NA 0.1008 mg/L 3compartmentss NA 50% Human Human +DTXSID6033241 Css NA 0.6789 mg/L 3compartmentss NA 95% Human Human +DTXSID6033241 Css NA 0.0724 mg/L PBTK NA 50% Human Human +DTXSID6033241 Css NA 0.456 mg/L PBTK NA 95% Human Human +DTXSID6033241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033241 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033241 Vd NA 0.955 L/kg 1compartment NA NA Rat Human +DTXSID6033241 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6033241 TK.Half.Life NA 0.7856 hours 1compartment NA NA Rat Human +DTXSID6033241 Css NA 0.01261 mg/L 3compartmentss NA 50% Rat Human +DTXSID6033241 Css NA 0.07004 mg/L 3compartmentss NA 95% Rat Human +DTXSID6033241 Css NA 0.008997 mg/L PBTK NA 50% Rat Human +DTXSID6033241 Css NA 0.04664 mg/L PBTK NA 95% Rat Human +DTXSID6033247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033247 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033247 Vd NA 1.086 L/kg 1compartment NA NA Human Human DTXSID6033247 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6033247 TK.Half.Life NA 7.512 hours 1compartment NA NA Human Human -DTXSID6033247 Css NA 0.4392 mg/L 3compartmentss NA 50% Human Human -DTXSID6033247 Css NA 2.299 mg/L 3compartmentss NA 95% Human Human -DTXSID6033247 Css NA 0.3508 mg/L PBTK NA 50% Human Human -DTXSID6033247 Css NA 1.604 mg/L PBTK NA 95% Human Human -DTXSID6033247 Clint NA 2.625 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033247 Fup NA 0.3849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033247 Vd NA 1.365 L/kg 1compartment NA NA Rat Human +DTXSID6033247 TK.Half.Life NA 2.095 hours 1compartment NA NA Human Human +DTXSID6033247 Css NA 0.1545 mg/L 3compartmentss NA 50% Human Human +DTXSID6033247 Css NA 1.148 mg/L 3compartmentss NA 95% Human Human +DTXSID6033247 Css NA 0.1052 mg/L PBTK NA 50% Human Human +DTXSID6033247 Css NA 0.7366 mg/L PBTK NA 95% Human Human +DTXSID6033247 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033247 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033247 Vd NA 0.8731 L/kg 1compartment NA NA Rat Human DTXSID6033247 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6033247 TK.Half.Life NA 2.778 hours 1compartment NA NA Rat Human -DTXSID6033247 Css NA 0.2048 mg/L 3compartmentss NA 50% Rat Human -DTXSID6033247 Css NA 0.7905 mg/L 3compartmentss NA 95% Rat Human -DTXSID6033247 Css NA 0.1568 mg/L PBTK NA 50% Rat Human -DTXSID6033247 Css NA 0.5109 mg/L PBTK NA 95% Rat Human -DTXSID6033326 Clint NA 28.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033326 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033326 Vd NA 3.107 L/kg 1compartment NA NA Human Human -DTXSID6033326 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID6033326 TK.Half.Life NA 64.6 hours 1compartment NA NA Human Human -DTXSID6033326 Css NA 2.496 mg/L 3compartmentss NA 50% Human Human -DTXSID6033326 Css NA 15.36 mg/L 3compartmentss NA 95% Human Human -DTXSID6033326 Css NA 1.734 mg/L PBTK NA 50% Human Human -DTXSID6033326 Css NA 10.23 mg/L PBTK NA 95% Human Human -DTXSID6033326 Clint NA 28.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033326 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033326 Vd NA 2.328 L/kg 1compartment NA NA Rat Human -DTXSID6033326 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID6033326 TK.Half.Life NA 8.984 hours 1compartment NA NA Rat Human -DTXSID6033326 Css NA 1.404 mg/L 3compartmentss NA 50% Rat Human -DTXSID6033326 Css NA 6.831 mg/L 3compartmentss NA 95% Rat Human -DTXSID6033326 Css NA 0.9302 mg/L PBTK NA 50% Rat Human -DTXSID6033326 Css NA 4.368 mg/L PBTK NA 95% Rat Human -DTXSID6033401 Clint NA 7.434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033401 Fup NA 0.0431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033401 Vd NA 0.2273 L/kg 1compartment NA NA Human Human +DTXSID6033247 TK.Half.Life NA 0.9003 hours 1compartment NA NA Rat Human +DTXSID6033247 Css NA 0.01963 mg/L 3compartmentss NA 50% Rat Human +DTXSID6033247 Css NA 0.1165 mg/L 3compartmentss NA 95% Rat Human +DTXSID6033247 Css NA 0.01316 mg/L PBTK NA 50% Rat Human +DTXSID6033247 Css NA 0.07289 mg/L PBTK NA 95% Rat Human +DTXSID6033401 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033401 Fup 0.0948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033401 Vd NA 0.2329 L/kg 1compartment NA NA Human Human DTXSID6033401 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6033401 TK.Half.Life NA 2.743 hours 1compartment NA NA Human Human -DTXSID6033401 Css NA 2.088 mg/L 3compartmentss NA 50% Human Human -DTXSID6033401 Css NA 13.87 mg/L 3compartmentss NA 95% Human Human -DTXSID6033401 Css NA 1.243 mg/L PBTK NA 50% Human Human -DTXSID6033401 Css NA 8.19 mg/L PBTK NA 95% Human Human -DTXSID6033401 Clint NA 7.434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033401 Fup NA 0.0431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033401 Vd NA 0.2208 L/kg 1compartment NA NA Rat Human +DTXSID6033401 TK.Half.Life NA 1.58 hours 1compartment NA NA Human Human +DTXSID6033401 Css NA 0.5484 mg/L 3compartmentss NA 50% Human Human +DTXSID6033401 Css NA 3.929 mg/L 3compartmentss NA 95% Human Human +DTXSID6033401 Css NA 0.3306 mg/L PBTK NA 50% Human Human +DTXSID6033401 Css NA 2.293 mg/L PBTK NA 95% Human Human +DTXSID6033401 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033401 Fup 0.0948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033401 Vd NA 0.2323 L/kg 1compartment NA NA Rat Human DTXSID6033401 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6033401 TK.Half.Life NA 1.683 hours 1compartment NA NA Rat Human -DTXSID6033401 Css NA 1.133 mg/L 3compartmentss NA 50% Rat Human -DTXSID6033401 Css NA 5.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID6033401 Css NA 0.6318 mg/L PBTK NA 50% Rat Human -DTXSID6033401 Css NA 3.123 mg/L PBTK NA 95% Rat Human -DTXSID6033538 Clint NA 5.157 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033538 Fup NA 0.0901 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033538 Vd NA 2.602 L/kg 1compartment NA NA Human Human -DTXSID6033538 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID6033538 TK.Half.Life NA 47.84 hours 1compartment NA NA Human Human -DTXSID6033538 Css NA 2.447 mg/L 3compartmentss NA 50% Human Human -DTXSID6033538 Css NA 13.42 mg/L 3compartmentss NA 95% Human Human -DTXSID6033538 Css NA 1.679 mg/L PBTK NA 50% Human Human -DTXSID6033538 Css NA 8.841 mg/L PBTK NA 95% Human Human -DTXSID6033538 Clint NA 5.157 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033538 Fup NA 0.0901 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033538 Vd NA 1.958 L/kg 1compartment NA NA Rat Human -DTXSID6033538 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6033538 TK.Half.Life NA 10.64 hours 1compartment NA NA Rat Human -DTXSID6033538 Css NA 1.272 mg/L 3compartmentss NA 50% Rat Human -DTXSID6033538 Css NA 5.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID6033538 Css NA 0.8337 mg/L PBTK NA 50% Rat Human -DTXSID6033538 Css NA 3.13 mg/L PBTK NA 95% Rat Human -DTXSID6033825 Clint NA 12.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033825 Fup NA 0.3659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6033825 Vd NA 1.494 L/kg 1compartment NA NA Human Human -DTXSID6033825 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6033825 TK.Half.Life NA 2.053 hours 1compartment NA NA Human Human -DTXSID6033825 Css NA 0.08392 mg/L 3compartmentss NA 50% Human Human -DTXSID6033825 Css NA 0.6154 mg/L 3compartmentss NA 95% Human Human -DTXSID6033825 Css NA 0.07098 mg/L PBTK NA 50% Human Human -DTXSID6033825 Css NA 0.4559 mg/L PBTK NA 95% Human Human -DTXSID6033825 Clint NA 12.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033825 Fup NA 0.3659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6033825 Vd NA 1.503 L/kg 1compartment NA NA Rat Human +DTXSID6033401 TK.Half.Life NA 0.9619 hours 1compartment NA NA Rat Human +DTXSID6033401 Css NA 0.005652 mg/L 3compartmentss NA 50% Rat Human +DTXSID6033401 Css NA 0.03469 mg/L 3compartmentss NA 95% Rat Human +DTXSID6033401 Css NA 0.003212 mg/L PBTK NA 50% Rat Human +DTXSID6033401 Css NA 0.01933 mg/L PBTK NA 95% Rat Human +DTXSID6033538 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033538 Fup 0.0555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033538 Vd NA 1.823 L/kg 1compartment NA NA Human Human +DTXSID6033538 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6033538 TK.Half.Life NA 8.637 hours 1compartment NA NA Human Human +DTXSID6033538 Css NA 0.6108 mg/L 3compartmentss NA 50% Human Human +DTXSID6033538 Css NA 4.288 mg/L 3compartmentss NA 95% Human Human +DTXSID6033538 Css NA 0.3966 mg/L PBTK NA 50% Human Human +DTXSID6033538 Css NA 2.708 mg/L PBTK NA 95% Human Human +DTXSID6033538 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033538 Fup 0.0555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033538 Vd NA 1.369 L/kg 1compartment NA NA Rat Human +DTXSID6033538 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6033538 TK.Half.Life NA 3.014 hours 1compartment NA NA Rat Human +DTXSID6033538 Css NA 0.07856 mg/L 3compartmentss NA 50% Rat Human +DTXSID6033538 Css NA 0.4428 mg/L 3compartmentss NA 95% Rat Human +DTXSID6033538 Css NA 0.04998 mg/L PBTK NA 50% Rat Human +DTXSID6033538 Css NA 0.2704 mg/L PBTK NA 95% Rat Human +DTXSID60337884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60337884 Fup 0.0539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60337884 Vd NA 2.243 L/kg 1compartment NA NA Human Human +DTXSID60337884 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60337884 TK.Half.Life NA 12.89 hours 1compartment NA NA Human Human +DTXSID60337884 Css NA 0.7275 mg/L 3compartmentss NA 50% Human Human +DTXSID60337884 Css NA 5.274 mg/L 3compartmentss NA 95% Human Human +DTXSID60337884 Css NA 0.4832 mg/L PBTK NA 50% Human Human +DTXSID60337884 Css NA 3.385 mg/L PBTK NA 95% Human Human +DTXSID60337884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60337884 Fup 0.0539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60337884 Vd NA 1.681 L/kg 1compartment NA NA Rat Human +DTXSID60337884 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60337884 TK.Half.Life NA 3.781 hours 1compartment NA NA Rat Human +DTXSID60337884 Css NA 0.0939 mg/L 3compartmentss NA 50% Rat Human +DTXSID60337884 Css NA 0.5166 mg/L 3compartmentss NA 95% Rat Human +DTXSID60337884 Css NA 0.06138 mg/L PBTK NA 50% Rat Human +DTXSID60337884 Css NA 0.3307 mg/L PBTK NA 95% Rat Human +DTXSID6033825 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033825 Fup 0.435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6033825 Vd NA 1.678 L/kg 1compartment NA NA Human Human +DTXSID6033825 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6033825 TK.Half.Life NA 24.96 hours 1compartment NA NA Human Human +DTXSID6033825 Css NA 1.327 mg/L 3compartmentss NA 50% Human Human +DTXSID6033825 Css NA 6.792 mg/L 3compartmentss NA 95% Human Human +DTXSID6033825 Css NA 1.21 mg/L PBTK NA 50% Human Human +DTXSID6033825 Css NA 4.723 mg/L PBTK NA 95% Human Human +DTXSID6033825 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033825 Fup 0.435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6033825 Vd NA 1.692 L/kg 1compartment NA NA Rat Human DTXSID6033825 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6033825 TK.Half.Life NA 1.148 hours 1compartment NA NA Rat Human -DTXSID6033825 Css NA 0.04294 mg/L 3compartmentss NA 50% Rat Human -DTXSID6033825 Css NA 0.2538 mg/L 3compartmentss NA 95% Rat Human -DTXSID6033825 Css NA 0.03564 mg/L PBTK NA 50% Rat Human -DTXSID6033825 Css NA 0.1714 mg/L PBTK NA 95% Rat Human -DTXSID6034005 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034005 Fup NA 0.5476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034005 Vd NA 0.5135 L/kg 1compartment NA NA Human Human -DTXSID6034005 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6034005 TK.Half.Life NA 6.064 hours 1compartment NA NA Human Human -DTXSID6034005 Css NA 1.392 mg/L 3compartmentss NA 50% Human Human -DTXSID6034005 Css NA 8.572 mg/L 3compartmentss NA 95% Human Human -DTXSID6034005 Css NA 1.053 mg/L PBTK NA 50% Human Human -DTXSID6034005 Css NA 5.312 mg/L PBTK NA 95% Human Human -DTXSID6034005 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034005 Fup NA 0.5476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034005 Vd NA 0.5439 L/kg 1compartment NA NA Rat Human -DTXSID6034005 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6034005 TK.Half.Life NA 2.189 hours 1compartment NA NA Rat Human -DTXSID6034005 Css NA 0.3712 mg/L 3compartmentss NA 50% Rat Human -DTXSID6034005 Css NA 2.108 mg/L 3compartmentss NA 95% Rat Human -DTXSID6034005 Css NA 0.2668 mg/L PBTK NA 50% Rat Human -DTXSID6034005 Css NA 1.22 mg/L PBTK NA 95% Rat Human -DTXSID6034186 Clint NA 30.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034186 Fup NA 0.0927 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034186 Vd NA 1.533 L/kg 1compartment NA NA Human Human -DTXSID6034186 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6034186 TK.Half.Life NA 3.725 hours 1compartment NA NA Human Human -DTXSID6034186 Css NA 0.2528 mg/L 3compartmentss NA 50% Human Human -DTXSID6034186 Css NA 1.964 mg/L 3compartmentss NA 95% Human Human -DTXSID6034186 Css NA 0.1676 mg/L PBTK NA 50% Human Human -DTXSID6034186 Css NA 1.235 mg/L PBTK NA 95% Human Human -DTXSID6034186 Clint NA 30.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034186 Fup NA 0.0927 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034186 Vd NA 1.17 L/kg 1compartment NA NA Rat Human +DTXSID6033825 TK.Half.Life NA 8.573 hours 1compartment NA NA Rat Human +DTXSID6033825 Css NA 0.08338 mg/L 3compartmentss NA 50% Rat Human +DTXSID6033825 Css NA 0.3738 mg/L 3compartmentss NA 95% Rat Human +DTXSID6033825 Css NA 0.0762 mg/L PBTK NA 50% Rat Human +DTXSID6033825 Css NA 0.2498 mg/L PBTK NA 95% Rat Human +DTXSID6034186 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6034186 Fup 0.0564 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6034186 Vd NA 1.216 L/kg 1compartment NA NA Human Human +DTXSID6034186 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6034186 TK.Half.Life NA 13.86 hours 1compartment NA NA Human Human +DTXSID6034186 Css NA 1.72 mg/L 3compartmentss NA 50% Human Human +DTXSID6034186 Css NA 11.3 mg/L 3compartmentss NA 95% Human Human +DTXSID6034186 Css NA 1.096 mg/L PBTK NA 50% Human Human +DTXSID6034186 Css NA 6.907 mg/L PBTK NA 95% Human Human +DTXSID6034186 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6034186 Fup 0.0564 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6034186 Vd NA 0.9235 L/kg 1compartment NA NA Rat Human DTXSID6034186 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6034186 TK.Half.Life NA 1.419 hours 1compartment NA NA Rat Human -DTXSID6034186 Css NA 0.1414 mg/L 3compartmentss NA 50% Rat Human -DTXSID6034186 Css NA 0.8732 mg/L 3compartmentss NA 95% Rat Human -DTXSID6034186 Css NA 0.08808 mg/L PBTK NA 50% Rat Human -DTXSID6034186 Css NA 0.5172 mg/L PBTK NA 95% Rat Human +DTXSID6034186 TK.Half.Life NA 5.691 hours 1compartment NA NA Rat Human +DTXSID6034186 Css NA 0.2138 mg/L 3compartmentss NA 50% Rat Human +DTXSID6034186 Css NA 1.075 mg/L 3compartmentss NA 95% Rat Human +DTXSID6034186 Css NA 0.1324 mg/L PBTK NA 50% Rat Human +DTXSID6034186 Css NA 0.6294 mg/L PBTK NA 95% Rat Human DTXSID6034265 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6034265 Fup 0.464 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6034265 Vd NA 0.6703 L/kg 1compartment NA NA Human Human +DTXSID6034265 Vd NA 0.5576 L/kg 1compartment NA NA Human Human DTXSID6034265 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6034265 TK.Half.Life NA 9.347 hours 1compartment NA NA Human Human -DTXSID6034265 Css NA 1.39 mg/L 3compartmentss NA 50% Human Human -DTXSID6034265 Css NA 4.258 mg/L 3compartmentss NA 95% Human Human -DTXSID6034265 Css NA 1.113 mg/L PBTK NA 50% Human Human -DTXSID6034265 Css NA 3.006 mg/L PBTK NA 95% Human Human +DTXSID6034265 TK.Half.Life NA 7.775 hours 1compartment NA NA Human Human +DTXSID6034265 Css NA 1.41 mg/L 3compartmentss NA 50% Human Human +DTXSID6034265 Css NA 4.212 mg/L 3compartmentss NA 95% Human Human +DTXSID6034265 Css NA 1.079 mg/L PBTK NA 50% Human Human +DTXSID6034265 Css NA 2.885 mg/L PBTK NA 95% Human Human DTXSID6034265 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6034265 Fup 0.464 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6034265 Vd NA 0.6798 L/kg 1compartment NA NA Rat Human +DTXSID6034265 Vd NA 0.5745 L/kg 1compartment NA NA Rat Human DTXSID6034265 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6034265 TK.Half.Life NA 3.23 hours 1compartment NA NA Rat Human -DTXSID6034265 Css NA 0.3757 mg/L 3compartmentss NA 50% Rat Human -DTXSID6034265 Css NA 0.9299 mg/L 3compartmentss NA 95% Rat Human -DTXSID6034265 Css NA 0.2913 mg/L PBTK NA 50% Rat Human -DTXSID6034265 Css NA 0.6071 mg/L PBTK NA 95% Rat Human +DTXSID6034265 TK.Half.Life NA 2.729 hours 1compartment NA NA Rat Human +DTXSID6034265 Css NA 0.08937 mg/L 3compartmentss NA 50% Rat Human +DTXSID6034265 Css NA 0.2172 mg/L 3compartmentss NA 95% Rat Human +DTXSID6034265 Css NA 0.06789 mg/L PBTK NA 50% Rat Human +DTXSID6034265 Css NA 0.1422 mg/L PBTK NA 95% Rat Human DTXSID6034392 Clint 17.28 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6034392 Fup 0.03201 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6034392 Vd NA 1.108 L/kg 1compartment NA NA Human Human DTXSID6034392 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6034392 TK.Half.Life NA 8.133 hours 1compartment NA NA Human Human -DTXSID6034392 Css NA 1.058 mg/L 3compartmentss NA 50% Human Human -DTXSID6034392 Css NA 10.12 mg/L 3compartmentss NA 95% Human Human -DTXSID6034392 Css NA 0.7368 mg/L PBTK NA 50% Human Human -DTXSID6034392 Css NA 6.416 mg/L PBTK NA 95% Human Human +DTXSID6034392 Css NA 0.983 mg/L 3compartmentss NA 50% Human Human +DTXSID6034392 Css NA 8.192 mg/L 3compartmentss NA 95% Human Human +DTXSID6034392 Css NA 0.7248 mg/L PBTK NA 50% Human Human +DTXSID6034392 Css NA 6.043 mg/L PBTK NA 95% Human Human DTXSID6034392 Clint 12.04 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID6034392 Fup 0.04664 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID6034392 Vd NA 0.9996 L/kg 1compartment NA NA Rat Rat +DTXSID6034392 Vd 2 0.9996 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID6034392 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID6034392 TK.Half.Life NA 4.133 hours 1compartment NA NA Rat Rat -DTXSID6034392 Css NA 0.5964 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6034392 Css NA 3.254 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6034392 Css NA 0.3902 mg/L PBTK NA 50% Rat Rat -DTXSID6034392 Css NA 1.937 mg/L PBTK NA 95% Rat Rat +DTXSID6034392 TK.Half.Life 0.25 4.133 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID6034392 Css 0.0078 0.12 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID6034392 Css 0.0078 0.6227 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID6034392 Css 0.0078 0.09164 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID6034392 Css 0.0078 0.4756 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID6034554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6034554 Fup 0.59 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human +DTXSID6034554 Vd NA 1.455 L/kg 1compartment NA NA Human Human +DTXSID6034554 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6034554 TK.Half.Life NA 1.312 hours 1compartment NA NA Human Human +DTXSID6034554 Css NA 0.03312 mg/L 3compartmentss NA 50% Human Human +DTXSID6034554 Css NA 0.2995 mg/L 3compartmentss NA 95% Human Human +DTXSID6034554 Css NA 0.02926 mg/L PBTK NA 50% Human Human +DTXSID6034554 Css NA 0.2652 mg/L PBTK NA 95% Human Human +DTXSID6034554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6034554 Fup 0.59 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human +DTXSID6034554 Vd NA 1.261 L/kg 1compartment NA NA Rat Human +DTXSID6034554 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6034554 TK.Half.Life NA 0.5479 hours 1compartment NA NA Rat Human +DTXSID6034554 Css NA 0.003924 mg/L 3compartmentss NA 50% Rat Human +DTXSID6034554 Css NA 0.02957 mg/L 3compartmentss NA 95% Rat Human +DTXSID6034554 Css NA 0.003617 mg/L PBTK NA 50% Rat Human +DTXSID6034554 Css NA 0.02721 mg/L PBTK NA 95% Rat Human DTXSID6034712 Clint 5.452 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID6034712 Fup 0 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human +DTXSID6034712 Fup 0.0888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6034712 Vd NA 435.6 L/kg 1compartment NA NA Human Human +DTXSID6034712 Days.Css NA 1450 Days PBTK NA NA Human Human +DTXSID6034712 TK.Half.Life NA 5419 hours 1compartment NA NA Human Human +DTXSID6034712 Css NA 0.01137 mg/L 3compartmentss NA 50% Human Human +DTXSID6034712 Css NA 0.1292 mg/L 3compartmentss NA 95% Human Human +DTXSID6034712 Css NA 0.6505 mg/L PBTK NA 50% Human Human +DTXSID6034712 Css NA 3.88 mg/L PBTK NA 95% Human Human DTXSID6034712 Clint 5.452 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID6034712 Fup 0 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID6034762 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034762 Fup NA 0.0492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034762 Vd NA 1.22 L/kg 1compartment NA NA Human Human -DTXSID6034762 Days.Css NA 44 Days PBTK NA NA Human Human -DTXSID6034762 TK.Half.Life NA 201.1 hours 1compartment NA NA Human Human -DTXSID6034762 Css NA 25.49 mg/L 3compartmentss NA 50% Human Human -DTXSID6034762 Css NA 118.2 mg/L 3compartmentss NA 95% Human Human -DTXSID6034762 Css NA 16.03 mg/L PBTK NA 50% Human Human -DTXSID6034762 Css NA 70.39 mg/L PBTK NA 95% Human Human -DTXSID6034762 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034762 Fup NA 0.0492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034762 Vd NA 0.9222 L/kg 1compartment NA NA Rat Human -DTXSID6034762 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID6034762 TK.Half.Life NA 43.81 hours 1compartment NA NA Rat Human -DTXSID6034762 Css NA 7.14 mg/L 3compartmentss NA 50% Rat Human -DTXSID6034762 Css NA 27.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID6034762 Css NA 4.228 mg/L PBTK NA 50% Rat Human -DTXSID6034762 Css NA 15.47 mg/L PBTK NA 95% Rat Human -DTXSID6034764 Clint NA 7.475 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034764 Fup NA 0.0957 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034764 Vd NA 0.2137 L/kg 1compartment NA NA Human Human -DTXSID6034764 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6034764 TK.Half.Life NA 1.24 hours 1compartment NA NA Human Human -DTXSID6034764 Css NA 0.8786 mg/L 3compartmentss NA 50% Human Human -DTXSID6034764 Css NA 6.059 mg/L 3compartmentss NA 95% Human Human -DTXSID6034764 Css NA 0.5268 mg/L PBTK NA 50% Human Human -DTXSID6034764 Css NA 3.566 mg/L PBTK NA 95% Human Human +DTXSID6034712 Fup 0.0888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6034712 Vd NA 394.6 L/kg 1compartment NA NA Rat Human +DTXSID6034712 Days.Css NA 874 Days PBTK NA NA Rat Human +DTXSID6034712 TK.Half.Life NA 1796 hours 1compartment NA NA Rat Human +DTXSID6034712 Css NA 0.0001028 mg/L 3compartmentss NA 50% Rat Human +DTXSID6034712 Css NA 0.0009215 mg/L 3compartmentss NA 95% Rat Human +DTXSID6034712 Css NA 0.00637 mg/L PBTK NA 50% Rat Human +DTXSID6034712 Css NA 0.03012 mg/L PBTK NA 95% Rat Human +DTXSID6034764 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6034764 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6034764 Vd NA 0.4558 L/kg 1compartment NA NA Human Human +DTXSID6034764 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6034764 TK.Half.Life NA 11.32 hours 1compartment NA NA Human Human +DTXSID6034764 Css NA 2.534 mg/L 3compartmentss NA 50% Human Human +DTXSID6034764 Css NA 9.93 mg/L 3compartmentss NA 95% Human Human +DTXSID6034764 Css NA 1.736 mg/L PBTK NA 50% Human Human +DTXSID6034764 Css NA 6.169 mg/L PBTK NA 95% Human Human DTXSID6034764 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID6034764 Fup 0.0947 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID6034764 Vd NA 0.2148 L/kg 1compartment NA NA Rat Rat +DTXSID6034764 Vd NA 0.2871 L/kg 1compartment NA NA Rat Rat DTXSID6034764 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID6034764 TK.Half.Life NA 5.001 hours 1compartment NA NA Rat Rat -DTXSID6034764 Css NA 3.122 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6034764 Css NA 12.01 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6034764 Css NA 1.751 mg/L PBTK NA 50% Rat Rat -DTXSID6034764 Css NA 6.551 mg/L PBTK NA 95% Rat Rat +DTXSID6034764 TK.Half.Life NA 6.684 hours 1compartment NA NA Rat Rat +DTXSID6034764 Css NA 0.2247 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6034764 Css NA 1.406 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6034764 Css NA 0.1331 mg/L PBTK NA 50% Rat Rat +DTXSID6034764 Css NA 0.8022 mg/L PBTK NA 95% Rat Rat DTXSID6034849 Clint 5.815 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID6034849 Fup 0.8435 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID6034849 Vd NA 3.618 L/kg 1compartment NA NA Human Human +DTXSID6034849 Vd NA 4.379 L/kg 1compartment NA NA Human Human DTXSID6034849 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6034849 TK.Half.Life NA 4.566 hours 1compartment NA NA Human Human -DTXSID6034849 Css NA 0.1046 mg/L 3compartmentss NA 50% Human Human -DTXSID6034849 Css NA 0.8238 mg/L 3compartmentss NA 95% Human Human -DTXSID6034849 Css NA 0.07644 mg/L PBTK NA 50% Human Human -DTXSID6034849 Css NA 0.5373 mg/L PBTK NA 95% Human Human +DTXSID6034849 TK.Half.Life NA 5.497 hours 1compartment NA NA Human Human +DTXSID6034849 Css NA 0.0948 mg/L 3compartmentss NA 50% Human Human +DTXSID6034849 Css NA 0.6925 mg/L 3compartmentss NA 95% Human Human +DTXSID6034849 Css NA 0.07184 mg/L PBTK NA 50% Human Human +DTXSID6034849 Css NA 0.528 mg/L PBTK NA 95% Human Human DTXSID6034849 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID6034849 Fup 0.7745 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID6034849 Vd NA 3.463 L/kg 1compartment NA NA Rat Rat +DTXSID6034849 Vd 6.7 4.202 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID6034849 Days.Css NA 1 Days PBTK NA NA Rat Rat -DTXSID6034849 TK.Half.Life NA 9.861 hours 1compartment NA NA Rat Rat -DTXSID6034849 Css NA 0.2872 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6034849 Css NA 1.655 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6034849 Css NA 0.2062 mg/L PBTK NA 50% Rat Rat -DTXSID6034849 Css NA 0.9569 mg/L PBTK NA 95% Rat Rat +DTXSID6034849 TK.Half.Life 0.21 11.98 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID6034849 Css 0.0019 0.06079 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID6034849 Css 0.0019 0.2848 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID6034849 Css 0.0019 0.04815 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID6034849 Css 0.0019 0.2256 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID6034924 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6034924 Fup NA 0.2836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034924 Vd NA 0.538 L/kg 1compartment NA NA Human Human +DTXSID6034924 Vd NA 0.5668 L/kg 1compartment NA NA Human Human DTXSID6034924 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6034924 TK.Half.Life NA 12.27 hours 1compartment NA NA Human Human -DTXSID6034924 Css NA 2.61 mg/L 3compartmentss NA 50% Human Human -DTXSID6034924 Css NA 10.35 mg/L 3compartmentss NA 95% Human Human -DTXSID6034924 Css NA 1.878 mg/L PBTK NA 50% Human Human -DTXSID6034924 Css NA 6.599 mg/L PBTK NA 95% Human Human +DTXSID6034924 TK.Half.Life NA 12.93 hours 1compartment NA NA Human Human +DTXSID6034924 Css NA 2.166 mg/L 3compartmentss NA 50% Human Human +DTXSID6034924 Css NA 8.693 mg/L 3compartmentss NA 95% Human Human +DTXSID6034924 Css NA 1.596 mg/L PBTK NA 50% Human Human +DTXSID6034924 Css NA 5.544 mg/L PBTK NA 95% Human Human DTXSID6034924 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6034924 Fup NA 0.2836 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034924 Vd NA 0.5416 L/kg 1compartment NA NA Rat Human +DTXSID6034924 Vd NA 0.5689 L/kg 1compartment NA NA Rat Human DTXSID6034924 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6034924 TK.Half.Life NA 4.211 hours 1compartment NA NA Rat Human -DTXSID6034924 Css NA 0.7121 mg/L 3compartmentss NA 50% Rat Human -DTXSID6034924 Css NA 2.385 mg/L 3compartmentss NA 95% Rat Human -DTXSID6034924 Css NA 0.4913 mg/L PBTK NA 50% Rat Human -DTXSID6034924 Css NA 1.413 mg/L PBTK NA 95% Rat Human +DTXSID6034924 TK.Half.Life NA 4.423 hours 1compartment NA NA Rat Human +DTXSID6034924 Css NA 0.03853 mg/L 3compartmentss NA 50% Rat Human +DTXSID6034924 Css NA 0.2387 mg/L 3compartmentss NA 95% Rat Human +DTXSID6034924 Css NA 0.02746 mg/L PBTK NA 50% Rat Human +DTXSID6034924 Css NA 0.1552 mg/L PBTK NA 95% Rat Human DTXSID6034928 Clint 44.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6034928 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034928 Vd NA 2.581 L/kg 1compartment NA NA Human Human -DTXSID6034928 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6034928 TK.Half.Life NA 25.52 hours 1compartment NA NA Human Human -DTXSID6034928 Css NA 1.361 mg/L 3compartmentss NA 50% Human Human -DTXSID6034928 Css NA 9.542 mg/L 3compartmentss NA 95% Human Human -DTXSID6034928 Css NA 0.9005 mg/L PBTK NA 50% Human Human -DTXSID6034928 Css NA 6.085 mg/L PBTK NA 95% Human Human +DTXSID6034928 Fup 0.00718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6034928 Vd NA 15.72 L/kg 1compartment NA NA Human Human +DTXSID6034928 Days.Css NA 45 Days PBTK NA NA Human Human +DTXSID6034928 TK.Half.Life NA 232.4 hours 1compartment NA NA Human Human +DTXSID6034928 Css NA 0.6844 mg/L 3compartmentss NA 50% Human Human +DTXSID6034928 Css NA 4.087 mg/L 3compartmentss NA 95% Human Human +DTXSID6034928 Css NA 1.166 mg/L PBTK NA 50% Human Human +DTXSID6034928 Css NA 6.639 mg/L PBTK NA 95% Human Human DTXSID6034928 Clint 44.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6034928 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034928 Vd NA 1.922 L/kg 1compartment NA NA Rat Human -DTXSID6034928 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6034928 TK.Half.Life NA 2.897 hours 1compartment NA NA Rat Human -DTXSID6034928 Css NA 0.313 mg/L 3compartmentss NA 50% Rat Human -DTXSID6034928 Css NA 2.004 mg/L 3compartmentss NA 95% Rat Human -DTXSID6034928 Css NA 0.1962 mg/L PBTK NA 50% Rat Human -DTXSID6034928 Css NA 1.211 mg/L PBTK NA 95% Rat Human -DTXSID6034972 Clint NA 15.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034972 Fup NA 0.1318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6034972 Vd NA 2.469 L/kg 1compartment NA NA Human Human +DTXSID6034928 Fup 0.00718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6034928 Vd NA 12.62 L/kg 1compartment NA NA Rat Human +DTXSID6034928 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID6034928 TK.Half.Life NA 15.01 hours 1compartment NA NA Rat Human +DTXSID6034928 Css NA 0.0347 mg/L 3compartmentss NA 50% Rat Human +DTXSID6034928 Css NA 0.1686 mg/L 3compartmentss NA 95% Rat Human +DTXSID6034928 Css NA 0.06252 mg/L PBTK NA 50% Rat Human +DTXSID6034928 Css NA 0.3215 mg/L PBTK NA 95% Rat Human +DTXSID6034972 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6034972 Fup 0.0778 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6034972 Vd NA 2.151 L/kg 1compartment NA NA Human Human DTXSID6034972 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6034972 TK.Half.Life NA 11.17 hours 1compartment NA NA Human Human -DTXSID6034972 Css NA 0.5188 mg/L 3compartmentss NA 50% Human Human -DTXSID6034972 Css NA 3.26 mg/L 3compartmentss NA 95% Human Human -DTXSID6034972 Css NA 0.361 mg/L PBTK NA 50% Human Human -DTXSID6034972 Css NA 2.172 mg/L PBTK NA 95% Human Human -DTXSID6034972 Clint NA 15.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034972 Fup NA 0.1318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6034972 Vd NA 1.868 L/kg 1compartment NA NA Rat Human +DTXSID6034972 TK.Half.Life NA 9.108 hours 1compartment NA NA Human Human +DTXSID6034972 Css NA 0.4978 mg/L 3compartmentss NA 50% Human Human +DTXSID6034972 Css NA 3.337 mg/L 3compartmentss NA 95% Human Human +DTXSID6034972 Css NA 0.3352 mg/L PBTK NA 50% Human Human +DTXSID6034972 Css NA 2.142 mg/L PBTK NA 95% Human Human +DTXSID6034972 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6034972 Fup 0.0778 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6034972 Vd NA 1.619 L/kg 1compartment NA NA Rat Human DTXSID6034972 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6034972 TK.Half.Life NA 2.984 hours 1compartment NA NA Rat Human -DTXSID6034972 Css NA 0.2814 mg/L 3compartmentss NA 50% Rat Human -DTXSID6034972 Css NA 1.389 mg/L 3compartmentss NA 95% Rat Human -DTXSID6034972 Css NA 0.1874 mg/L PBTK NA 50% Rat Human -DTXSID6034972 Css NA 0.8914 mg/L PBTK NA 95% Rat Human +DTXSID6034972 TK.Half.Life NA 2.821 hours 1compartment NA NA Rat Human +DTXSID6034972 Css NA 0.06437 mg/L 3compartmentss NA 50% Rat Human +DTXSID6034972 Css NA 0.3451 mg/L 3compartmentss NA 95% Rat Human +DTXSID6034972 Css NA 0.04264 mg/L PBTK NA 50% Rat Human +DTXSID6034972 Css NA 0.2192 mg/L PBTK NA 95% Rat Human DTXSID6035106 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6035106 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6035106 Vd NA 0.6785 L/kg 1compartment NA NA Human Human DTXSID6035106 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6035106 TK.Half.Life NA 4.393 hours 1compartment NA NA Human Human -DTXSID6035106 Css NA 0.8521 mg/L 3compartmentss NA 50% Human Human -DTXSID6035106 Css NA 5.581 mg/L 3compartmentss NA 95% Human Human -DTXSID6035106 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID6035106 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID6035106 Css NA 0.718 mg/L 3compartmentss NA 50% Human Human +DTXSID6035106 Css NA 5.077 mg/L 3compartmentss NA 95% Human Human +DTXSID6035106 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID6035106 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID6035106 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6035106 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6035106 Vd NA 0.7328 L/kg 1compartment NA NA Rat Human DTXSID6035106 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6035106 TK.Half.Life NA 1.616 hours 1compartment NA NA Rat Human -DTXSID6035106 Css NA 0.2141 mg/L 3compartmentss NA 50% Rat Human -DTXSID6035106 Css NA 1.341 mg/L 3compartmentss NA 95% Rat Human -DTXSID6035106 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID6035106 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID6035784 Clint NA 49.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6035784 Fup NA 0.0168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6035784 Vd NA 5.144 L/kg 1compartment NA NA Human Human -DTXSID6035784 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID6035784 TK.Half.Life NA 69.87 hours 1compartment NA NA Human Human -DTXSID6035784 Css NA 1.285 mg/L 3compartmentss NA 50% Human Human -DTXSID6035784 Css NA 7.682 mg/L 3compartmentss NA 95% Human Human -DTXSID6035784 Css NA 1.053 mg/L PBTK NA 50% Human Human -DTXSID6035784 Css NA 6.115 mg/L PBTK NA 95% Human Human -DTXSID6035784 Clint NA 49.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6035784 Fup NA 0.0168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6035784 Vd NA 3.933 L/kg 1compartment NA NA Rat Human -DTXSID6035784 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID6035784 TK.Half.Life NA 9.892 hours 1compartment NA NA Rat Human -DTXSID6035784 Css NA 0.7235 mg/L 3compartmentss NA 50% Rat Human -DTXSID6035784 Css NA 3.083 mg/L 3compartmentss NA 95% Rat Human -DTXSID6035784 Css NA 0.579 mg/L PBTK NA 50% Rat Human -DTXSID6035784 Css NA 2.426 mg/L PBTK NA 95% Rat Human +DTXSID6035106 Css NA 0.01318 mg/L 3compartmentss NA 50% Rat Human +DTXSID6035106 Css NA 0.1005 mg/L 3compartmentss NA 95% Rat Human +DTXSID6035106 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID6035106 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID6035156 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6035156 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6035156 Vd NA 2.175 L/kg 1compartment NA NA Human Human +DTXSID6035156 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6035156 TK.Half.Life NA 6.205 hours 1compartment NA NA Human Human +DTXSID6035156 Css NA 0.2788 mg/L 3compartmentss NA 50% Human Human +DTXSID6035156 Css NA 1.988 mg/L 3compartmentss NA 95% Human Human +DTXSID6035156 Css NA 0.1948 mg/L PBTK NA 50% Human Human +DTXSID6035156 Css NA 1.328 mg/L PBTK NA 95% Human Human +DTXSID6035156 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6035156 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6035156 Vd NA 1.655 L/kg 1compartment NA NA Rat Human +DTXSID6035156 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6035156 TK.Half.Life NA 1.95 hours 1compartment NA NA Rat Human +DTXSID6035156 Css NA 0.03569 mg/L 3compartmentss NA 50% Rat Human +DTXSID6035156 Css NA 0.2028 mg/L 3compartmentss NA 95% Rat Human +DTXSID6035156 Css NA 0.0245 mg/L PBTK NA 50% Rat Human +DTXSID6035156 Css NA 0.1317 mg/L PBTK NA 95% Rat Human DTXSID6036467 Clint NA 292.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6036467 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6036467 Vd NA 0.2787 L/kg 1compartment NA NA Human Human +DTXSID6036467 Vd NA 0.1611 L/kg 1compartment NA NA Human Human DTXSID6036467 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6036467 TK.Half.Life NA 1.807 hours 1compartment NA NA Human Human -DTXSID6036467 Css NA 1.077 mg/L 3compartmentss NA 50% Human Human -DTXSID6036467 Css NA 9.529 mg/L 3compartmentss NA 95% Human Human -DTXSID6036467 Css NA 0.6329 mg/L PBTK NA 50% Human Human -DTXSID6036467 Css NA 5.629 mg/L PBTK NA 95% Human Human +DTXSID6036467 TK.Half.Life NA 0.494 hours 1compartment NA NA Human Human +DTXSID6036467 Css NA 0.2067 mg/L 3compartmentss NA 50% Human Human +DTXSID6036467 Css NA 2.059 mg/L 3compartmentss NA 95% Human Human +DTXSID6036467 Css NA 0.12 mg/L PBTK NA 50% Human Human +DTXSID6036467 Css NA 1.197 mg/L PBTK NA 95% Human Human DTXSID6036467 Clint NA 292.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6036467 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6036467 Vd NA 0.2437 L/kg 1compartment NA NA Rat Human +DTXSID6036467 Vd NA 0.1599 L/kg 1compartment NA NA Rat Human DTXSID6036467 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6036467 TK.Half.Life NA 1.04 hours 1compartment NA NA Rat Human -DTXSID6036467 Css NA 0.6285 mg/L 3compartmentss NA 50% Rat Human -DTXSID6036467 Css NA 4.292 mg/L 3compartmentss NA 95% Rat Human -DTXSID6036467 Css NA 0.3451 mg/L PBTK NA 50% Rat Human -DTXSID6036467 Css NA 2.328 mg/L PBTK NA 95% Rat Human -DTXSID6037015 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037015 Fup NA 0.3474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037015 Vd NA 3.285 L/kg 1compartment NA NA Human Human -DTXSID6037015 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID6037015 TK.Half.Life NA 155200 hours 1compartment NA NA Human Human -DTXSID6037015 Css NA 5138 mg/L 3compartmentss NA 50% Human Human -DTXSID6037015 Css NA 11530 mg/L 3compartmentss NA 95% Human Human -DTXSID6037015 Css NA 3625 mg/L PBTK NA 50% Human Human -DTXSID6037015 Css NA 7848 mg/L PBTK NA 95% Human Human -DTXSID6037015 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037015 Fup NA 0.3474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037015 Vd NA 2.466 L/kg 1compartment NA NA Rat Human -DTXSID6037015 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID6037015 TK.Half.Life NA 9476 hours 1compartment NA NA Rat Human -DTXSID6037015 Css NA 1425 mg/L 3compartmentss NA 50% Rat Human -DTXSID6037015 Css NA 2072 mg/L 3compartmentss NA 95% Rat Human -DTXSID6037015 Css NA 964.6 mg/L PBTK NA 50% Rat Human -DTXSID6037015 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID6037069 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6036467 TK.Half.Life NA 0.3023 hours 1compartment NA NA Rat Human +DTXSID6036467 Css NA 0.002338 mg/L 3compartmentss NA 50% Rat Human +DTXSID6036467 Css NA 0.02064 mg/L 3compartmentss NA 95% Rat Human +DTXSID6036467 Css NA 0.001267 mg/L PBTK NA 50% Rat Human +DTXSID6036467 Css NA 0.01117 mg/L PBTK NA 95% Rat Human +DTXSID6037069 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6037069 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6037069 Vd NA 0.2572 L/kg 1compartment NA NA Human Human DTXSID6037069 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID6037069 TK.Half.Life NA 13.86 hours 1compartment NA NA Human Human -DTXSID6037069 Css NA 8.468 mg/L 3compartmentss NA 50% Human Human -DTXSID6037069 Css NA 37.6 mg/L 3compartmentss NA 95% Human Human -DTXSID6037069 Css NA 5.176 mg/L PBTK NA 50% Human Human -DTXSID6037069 Css NA 22.2 mg/L PBTK NA 95% Human Human -DTXSID6037069 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6037069 Css NA 7.04 mg/L 3compartmentss NA 50% Human Human +DTXSID6037069 Css NA 32.39 mg/L 3compartmentss NA 95% Human Human +DTXSID6037069 Css NA 4.33 mg/L PBTK NA 50% Human Human +DTXSID6037069 Css NA 19.01 mg/L PBTK NA 95% Human Human +DTXSID6037069 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6037069 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6037069 Vd NA 0.2664 L/kg 1compartment NA NA Rat Human DTXSID6037069 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6037069 TK.Half.Life NA 4.895 hours 1compartment NA NA Rat Human -DTXSID6037069 Css NA 2.366 mg/L 3compartmentss NA 50% Rat Human -DTXSID6037069 Css NA 8.951 mg/L 3compartmentss NA 95% Rat Human -DTXSID6037069 Css NA 1.36 mg/L PBTK NA 50% Rat Human -DTXSID6037069 Css NA 4.92 mg/L PBTK NA 95% Rat Human -DTXSID6037483 Clint NA 22.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037483 Fup NA 0.1396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037483 Vd NA 0.3544 L/kg 1compartment NA NA Human Human +DTXSID6037069 Css NA 0.131 mg/L 3compartmentss NA 50% Rat Human +DTXSID6037069 Css NA 0.8562 mg/L 3compartmentss NA 95% Rat Human +DTXSID6037069 Css NA 0.07664 mg/L PBTK NA 50% Rat Human +DTXSID6037069 Css NA 0.4856 mg/L PBTK NA 95% Rat Human +DTXSID6037483 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037483 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037483 Vd NA 0.4036 L/kg 1compartment NA NA Human Human DTXSID6037483 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6037483 TK.Half.Life NA 0.7155 hours 1compartment NA NA Human Human -DTXSID6037483 Css NA 0.1914 mg/L 3compartmentss NA 50% Human Human -DTXSID6037483 Css NA 1.504 mg/L 3compartmentss NA 95% Human Human -DTXSID6037483 Css NA 0.1236 mg/L PBTK NA 50% Human Human -DTXSID6037483 Css NA 0.9157 mg/L PBTK NA 95% Human Human -DTXSID6037483 Clint NA 22.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037483 Fup NA 0.1396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037483 Vd NA 0.3475 L/kg 1compartment NA NA Rat Human +DTXSID6037483 TK.Half.Life NA 1.057 hours 1compartment NA NA Human Human +DTXSID6037483 Css NA 0.1214 mg/L 3compartmentss NA 50% Human Human +DTXSID6037483 Css NA 0.8766 mg/L 3compartmentss NA 95% Human Human +DTXSID6037483 Css NA 0.08372 mg/L PBTK NA 50% Human Human +DTXSID6037483 Css NA 0.5602 mg/L PBTK NA 95% Human Human +DTXSID6037483 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037483 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037483 Vd NA 0.4032 L/kg 1compartment NA NA Rat Human DTXSID6037483 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6037483 TK.Half.Life NA 0.4028 hours 1compartment NA NA Rat Human -DTXSID6037483 Css NA 0.1051 mg/L 3compartmentss NA 50% Rat Human -DTXSID6037483 Css NA 0.642 mg/L 3compartmentss NA 95% Rat Human -DTXSID6037483 Css NA 0.06387 mg/L PBTK NA 50% Rat Human -DTXSID6037483 Css NA 0.3671 mg/L PBTK NA 95% Rat Human -DTXSID6037564 Clint NA 22.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037564 Fup NA 0.0271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037564 Vd NA 2.209 L/kg 1compartment NA NA Human Human +DTXSID6037483 TK.Half.Life NA 0.6043 hours 1compartment NA NA Rat Human +DTXSID6037483 Css NA 0.001158 mg/L 3compartmentss NA 50% Rat Human +DTXSID6037483 Css NA 0.00725 mg/L 3compartmentss NA 95% Rat Human +DTXSID6037483 Css NA 0.0007631 mg/L PBTK NA 50% Rat Human +DTXSID6037483 Css NA 0.004381 mg/L PBTK NA 95% Rat Human +DTXSID6037564 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037564 Fup 0.0229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037564 Vd NA 2.105 L/kg 1compartment NA NA Human Human DTXSID6037564 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6037564 TK.Half.Life NA 19.2 hours 1compartment NA NA Human Human -DTXSID6037564 Css NA 1.248 mg/L 3compartmentss NA 50% Human Human -DTXSID6037564 Css NA 9.748 mg/L 3compartmentss NA 95% Human Human -DTXSID6037564 Css NA 0.8166 mg/L PBTK NA 50% Human Human -DTXSID6037564 Css NA 6.111 mg/L PBTK NA 95% Human Human -DTXSID6037564 Clint NA 22.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037564 Fup NA 0.0271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037564 Vd NA 1.647 L/kg 1compartment NA NA Rat Human -DTXSID6037564 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6037564 TK.Half.Life NA 5.631 hours 1compartment NA NA Rat Human -DTXSID6037564 Css NA 0.6988 mg/L 3compartmentss NA 50% Rat Human -DTXSID6037564 Css NA 4.394 mg/L 3compartmentss NA 95% Rat Human -DTXSID6037564 Css NA 0.4304 mg/L PBTK NA 50% Rat Human -DTXSID6037564 Css NA 2.594 mg/L PBTK NA 95% Rat Human -DTXSID6037568 Clint NA 2.651 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037568 Fup NA 0.0532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037568 Vd NA 0.3183 L/kg 1compartment NA NA Human Human +DTXSID6037564 TK.Half.Life NA 20.3 hours 1compartment NA NA Human Human +DTXSID6037564 Css NA 1.379 mg/L 3compartmentss NA 50% Human Human +DTXSID6037564 Css NA 11.6 mg/L 3compartmentss NA 95% Human Human +DTXSID6037564 Css NA 0.8905 mg/L PBTK NA 50% Human Human +DTXSID6037564 Css NA 7.219 mg/L PBTK NA 95% Human Human +DTXSID6037564 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037564 Fup 0.0229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037564 Vd NA 1.566 L/kg 1compartment NA NA Rat Human +DTXSID6037564 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6037564 TK.Half.Life NA 6.239 hours 1compartment NA NA Rat Human +DTXSID6037564 Css NA 0.1816 mg/L 3compartmentss NA 50% Rat Human +DTXSID6037564 Css NA 1.191 mg/L 3compartmentss NA 95% Rat Human +DTXSID6037564 Css NA 0.1151 mg/L PBTK NA 50% Rat Human +DTXSID6037564 Css NA 0.7118 mg/L PBTK NA 95% Rat Human +DTXSID6037568 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037568 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037568 Vd NA 0.7518 L/kg 1compartment NA NA Human Human DTXSID6037568 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6037568 TK.Half.Life NA 7.379 hours 1compartment NA NA Human Human -DTXSID6037568 Css NA 3.907 mg/L 3compartmentss NA 50% Human Human -DTXSID6037568 Css NA 23.57 mg/L 3compartmentss NA 95% Human Human -DTXSID6037568 Css NA 2.403 mg/L PBTK NA 50% Human Human -DTXSID6037568 Css NA 13.83 mg/L PBTK NA 95% Human Human -DTXSID6037568 Clint NA 2.651 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037568 Fup NA 0.0532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037568 Vd NA 0.3121 L/kg 1compartment NA NA Rat Human +DTXSID6037568 TK.Half.Life NA 0.9563 hours 1compartment NA NA Human Human +DTXSID6037568 Css NA 0.06476 mg/L 3compartmentss NA 50% Human Human +DTXSID6037568 Css NA 0.5065 mg/L 3compartmentss NA 95% Human Human +DTXSID6037568 Css NA 0.05166 mg/L PBTK NA 50% Human Human +DTXSID6037568 Css NA 0.3659 mg/L PBTK NA 95% Human Human +DTXSID6037568 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037568 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037568 Vd NA 0.7481 L/kg 1compartment NA NA Rat Human DTXSID6037568 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6037568 TK.Half.Life NA 4.191 hours 1compartment NA NA Rat Human -DTXSID6037568 Css NA 1.89 mg/L 3compartmentss NA 50% Rat Human -DTXSID6037568 Css NA 9.128 mg/L 3compartmentss NA 95% Rat Human -DTXSID6037568 Css NA 1.092 mg/L PBTK NA 50% Rat Human -DTXSID6037568 Css NA 5.011 mg/L PBTK NA 95% Rat Human -DTXSID6037649 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037649 Fup NA 0.5519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037649 Vd NA 0.6299 L/kg 1compartment NA NA Human Human +DTXSID6037568 TK.Half.Life NA 0.5184 hours 1compartment NA NA Rat Human +DTXSID6037568 Css NA 0.008113 mg/L 3compartmentss NA 50% Rat Human +DTXSID6037568 Css NA 0.04831 mg/L 3compartmentss NA 95% Rat Human +DTXSID6037568 Css NA 0.006487 mg/L PBTK NA 50% Rat Human +DTXSID6037568 Css NA 0.03374 mg/L PBTK NA 95% Rat Human +DTXSID6037649 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037649 Fup 0.655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037649 Vd NA 0.6933 L/kg 1compartment NA NA Human Human DTXSID6037649 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6037649 TK.Half.Life NA 7.408 hours 1compartment NA NA Human Human -DTXSID6037649 Css NA 1.352 mg/L 3compartmentss NA 50% Human Human -DTXSID6037649 Css NA 8.97 mg/L 3compartmentss NA 95% Human Human -DTXSID6037649 Css NA 1.043 mg/L PBTK NA 50% Human Human -DTXSID6037649 Css NA 5.618 mg/L PBTK NA 95% Human Human -DTXSID6037649 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037649 Fup NA 0.5519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037649 Vd NA 0.638 L/kg 1compartment NA NA Rat Human +DTXSID6037649 TK.Half.Life NA 6.863 hours 1compartment NA NA Human Human +DTXSID6037649 Css NA 0.6238 mg/L 3compartmentss NA 50% Human Human +DTXSID6037649 Css NA 4.177 mg/L 3compartmentss NA 95% Human Human +DTXSID6037649 Css NA 0.5046 mg/L PBTK NA 50% Human Human +DTXSID6037649 Css NA 2.665 mg/L PBTK NA 95% Human Human +DTXSID6037649 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037649 Fup 0.655 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037649 Vd NA 0.709 L/kg 1compartment NA NA Rat Human DTXSID6037649 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6037649 TK.Half.Life NA 2.55 hours 1compartment NA NA Rat Human -DTXSID6037649 Css NA 0.3593 mg/L 3compartmentss NA 50% Rat Human -DTXSID6037649 Css NA 2.091 mg/L 3compartmentss NA 95% Rat Human -DTXSID6037649 Css NA 0.2661 mg/L PBTK NA 50% Rat Human -DTXSID6037649 Css NA 1.22 mg/L PBTK NA 95% Rat Human -DTXSID6037697 Clint NA 3.822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037697 Fup NA 0.4348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6037697 Vd NA 1.117 L/kg 1compartment NA NA Human Human +DTXSID6037649 TK.Half.Life NA 2.388 hours 1compartment NA NA Rat Human +DTXSID6037649 Css NA 0.003256 mg/L 3compartmentss NA 50% Rat Human +DTXSID6037649 Css NA 0.0225 mg/L 3compartmentss NA 95% Rat Human +DTXSID6037649 Css NA 0.002555 mg/L PBTK NA 50% Rat Human +DTXSID6037649 Css NA 0.01395 mg/L PBTK NA 95% Rat Human +DTXSID6037697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037697 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6037697 Vd NA 0.9227 L/kg 1compartment NA NA Human Human DTXSID6037697 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6037697 TK.Half.Life NA 2.972 hours 1compartment NA NA Human Human -DTXSID6037697 Css NA 0.2356 mg/L 3compartmentss NA 50% Human Human -DTXSID6037697 Css NA 1.534 mg/L 3compartmentss NA 95% Human Human -DTXSID6037697 Css NA 0.1888 mg/L PBTK NA 50% Human Human -DTXSID6037697 Css NA 1.047 mg/L PBTK NA 95% Human Human -DTXSID6037697 Clint NA 3.822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037697 Fup NA 0.4348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6037697 Vd NA 0.9797 L/kg 1compartment NA NA Rat Human +DTXSID6037697 TK.Half.Life NA 1.174 hours 1compartment NA NA Human Human +DTXSID6037697 Css NA 0.06415 mg/L 3compartmentss NA 50% Human Human +DTXSID6037697 Css NA 0.4722 mg/L 3compartmentss NA 95% Human Human +DTXSID6037697 Css NA 0.04744 mg/L PBTK NA 50% Human Human +DTXSID6037697 Css NA 0.3211 mg/L PBTK NA 95% Human Human +DTXSID6037697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037697 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6037697 Vd NA 0.808 L/kg 1compartment NA NA Rat Human DTXSID6037697 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6037697 TK.Half.Life NA 1.381 hours 1compartment NA NA Rat Human -DTXSID6037697 Css NA 0.114 mg/L 3compartmentss NA 50% Rat Human -DTXSID6037697 Css NA 0.5542 mg/L 3compartmentss NA 95% Rat Human -DTXSID6037697 Css NA 0.08792 mg/L PBTK NA 50% Rat Human -DTXSID6037697 Css NA 0.349 mg/L PBTK NA 95% Rat Human +DTXSID6037697 TK.Half.Life NA 0.534 hours 1compartment NA NA Rat Human +DTXSID6037697 Css NA 0.007984 mg/L 3compartmentss NA 50% Rat Human +DTXSID6037697 Css NA 0.04947 mg/L 3compartmentss NA 95% Rat Human +DTXSID6037697 Css NA 0.005888 mg/L PBTK NA 50% Rat Human +DTXSID6037697 Css NA 0.03257 mg/L PBTK NA 95% Rat Human DTXSID6037728 Clint 94.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6037728 Fup 0.0185 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6037728 Vd NA 0.4918 L/kg 1compartment NA NA Human Human +DTXSID6037728 Vd NA 0.4779 L/kg 1compartment NA NA Human Human DTXSID6037728 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6037728 TK.Half.Life NA 1.474 hours 1compartment NA NA Human Human -DTXSID6037728 Css NA 0.2784 mg/L 3compartmentss NA 50% Human Human -DTXSID6037728 Css NA 1.901 mg/L 3compartmentss NA 95% Human Human -DTXSID6037728 Css NA 0.1681 mg/L PBTK NA 50% Human Human -DTXSID6037728 Css NA 1.126 mg/L PBTK NA 95% Human Human +DTXSID6037728 TK.Half.Life NA 1.434 hours 1compartment NA NA Human Human +DTXSID6037728 Css NA 0.2662 mg/L 3compartmentss NA 50% Human Human +DTXSID6037728 Css NA 1.942 mg/L 3compartmentss NA 95% Human Human +DTXSID6037728 Css NA 0.1597 mg/L PBTK NA 50% Human Human +DTXSID6037728 Css NA 1.157 mg/L PBTK NA 95% Human Human DTXSID6037728 Clint 94.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6037728 Fup 0.0185 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6037728 Vd NA 0.3815 L/kg 1compartment NA NA Rat Human +DTXSID6037728 Vd NA 0.3721 L/kg 1compartment NA NA Rat Human DTXSID6037728 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6037728 TK.Half.Life NA 0.687 hours 1compartment NA NA Rat Human -DTXSID6037728 Css NA 0.1612 mg/L 3compartmentss NA 50% Rat Human -DTXSID6037728 Css NA 0.9201 mg/L 3compartmentss NA 95% Rat Human -DTXSID6037728 Css NA 0.09022 mg/L PBTK NA 50% Rat Human -DTXSID6037728 Css NA 0.5101 mg/L PBTK NA 95% Rat Human -DTXSID6038827 Clint NA 7.661 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6038827 Fup NA 0.2625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6038827 Vd NA 1.541 L/kg 1compartment NA NA Human Human +DTXSID6037728 TK.Half.Life NA 0.6717 hours 1compartment NA NA Rat Human +DTXSID6037728 Css NA 0.03654 mg/L 3compartmentss NA 50% Rat Human +DTXSID6037728 Css NA 0.2145 mg/L 3compartmentss NA 95% Rat Human +DTXSID6037728 Css NA 0.02112 mg/L PBTK NA 50% Rat Human +DTXSID6037728 Css NA 0.1232 mg/L PBTK NA 95% Rat Human +DTXSID6038798 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6038798 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6038798 Vd NA 1.626 L/kg 1compartment NA NA Human Human +DTXSID6038798 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6038798 TK.Half.Life NA 2.873 hours 1compartment NA NA Human Human +DTXSID6038798 Css NA 0.1221 mg/L 3compartmentss NA 50% Human Human +DTXSID6038798 Css NA 0.8149 mg/L 3compartmentss NA 95% Human Human +DTXSID6038798 Css NA 0.0879 mg/L PBTK NA 50% Human Human +DTXSID6038798 Css NA 0.5504 mg/L PBTK NA 95% Human Human +DTXSID6038798 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6038798 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6038798 Vd NA 1.277 L/kg 1compartment NA NA Rat Human +DTXSID6038798 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6038798 TK.Half.Life NA 1.093 hours 1compartment NA NA Rat Human +DTXSID6038798 Css NA 0.01518 mg/L 3compartmentss NA 50% Rat Human +DTXSID6038798 Css NA 0.07913 mg/L 3compartmentss NA 95% Rat Human +DTXSID6038798 Css NA 0.01092 mg/L PBTK NA 50% Rat Human +DTXSID6038798 Css NA 0.0538 mg/L PBTK NA 95% Rat Human +DTXSID6038827 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6038827 Fup 0.0921 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6038827 Vd NA 0.9063 L/kg 1compartment NA NA Human Human DTXSID6038827 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6038827 TK.Half.Life NA 4.359 hours 1compartment NA NA Human Human -DTXSID6038827 Css NA 0.259 mg/L 3compartmentss NA 50% Human Human -DTXSID6038827 Css NA 1.56 mg/L 3compartmentss NA 95% Human Human -DTXSID6038827 Css NA 0.1918 mg/L PBTK NA 50% Human Human -DTXSID6038827 Css NA 1.07 mg/L PBTK NA 95% Human Human -DTXSID6038827 Clint NA 7.661 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6038827 Fup NA 0.2625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6038827 Vd NA 1.232 L/kg 1compartment NA NA Rat Human +DTXSID6038827 TK.Half.Life NA 2.5 hours 1compartment NA NA Human Human +DTXSID6038827 Css NA 0.3107 mg/L 3compartmentss NA 50% Human Human +DTXSID6038827 Css NA 2.377 mg/L 3compartmentss NA 95% Human Human +DTXSID6038827 Css NA 0.1986 mg/L PBTK NA 50% Human Human +DTXSID6038827 Css NA 1.454 mg/L PBTK NA 95% Human Human +DTXSID6038827 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6038827 Fup 0.0921 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6038827 Vd NA 0.7171 L/kg 1compartment NA NA Rat Human DTXSID6038827 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6038827 TK.Half.Life NA 1.735 hours 1compartment NA NA Rat Human -DTXSID6038827 Css NA 0.1343 mg/L 3compartmentss NA 50% Rat Human -DTXSID6038827 Css NA 0.5853 mg/L 3compartmentss NA 95% Rat Human -DTXSID6038827 Css NA 0.09601 mg/L PBTK NA 50% Rat Human -DTXSID6038827 Css NA 0.3778 mg/L PBTK NA 95% Rat Human -DTXSID6038875 Clint NA 55.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6038875 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6038875 Vd NA 1.74 L/kg 1compartment NA NA Human Human +DTXSID6038827 TK.Half.Life NA 1.12 hours 1compartment NA NA Rat Human +DTXSID6038827 Css NA 0.03994 mg/L 3compartmentss NA 50% Rat Human +DTXSID6038827 Css NA 0.2587 mg/L 3compartmentss NA 95% Rat Human +DTXSID6038827 Css NA 0.025 mg/L PBTK NA 50% Rat Human +DTXSID6038827 Css NA 0.1552 mg/L PBTK NA 95% Rat Human +DTXSID6038875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6038875 Fup 0.0627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6038875 Vd NA 1.667 L/kg 1compartment NA NA Human Human DTXSID6038875 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6038875 TK.Half.Life NA 3.775 hours 1compartment NA NA Human Human -DTXSID6038875 Css NA 0.2131 mg/L 3compartmentss NA 50% Human Human -DTXSID6038875 Css NA 1.62 mg/L 3compartmentss NA 95% Human Human -DTXSID6038875 Css NA 0.139 mg/L PBTK NA 50% Human Human -DTXSID6038875 Css NA 1.02 mg/L PBTK NA 95% Human Human -DTXSID6038875 Clint NA 55.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6038875 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6038875 Vd NA 1.311 L/kg 1compartment NA NA Rat Human +DTXSID6038875 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human +DTXSID6038875 Css NA 0.519 mg/L 3compartmentss NA 50% Human Human +DTXSID6038875 Css NA 3.604 mg/L 3compartmentss NA 95% Human Human +DTXSID6038875 Css NA 0.3357 mg/L PBTK NA 50% Human Human +DTXSID6038875 Css NA 2.255 mg/L PBTK NA 95% Human Human +DTXSID6038875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6038875 Fup 0.0627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6038875 Vd NA 1.256 L/kg 1compartment NA NA Rat Human DTXSID6038875 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6038875 TK.Half.Life NA 1.341 hours 1compartment NA NA Rat Human -DTXSID6038875 Css NA 0.1196 mg/L 3compartmentss NA 50% Rat Human -DTXSID6038875 Css NA 0.713 mg/L 3compartmentss NA 95% Rat Human -DTXSID6038875 Css NA 0.07385 mg/L PBTK NA 50% Rat Human -DTXSID6038875 Css NA 0.4204 mg/L PBTK NA 95% Rat Human -DTXSID6038877 Clint NA 48.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6038877 Fup NA 0.0184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6038877 Vd NA 2.158 L/kg 1compartment NA NA Human Human +DTXSID6038875 TK.Half.Life NA 2.54 hours 1compartment NA NA Rat Human +DTXSID6038875 Css NA 0.06672 mg/L 3compartmentss NA 50% Rat Human +DTXSID6038875 Css NA 0.3783 mg/L 3compartmentss NA 95% Rat Human +DTXSID6038875 Css NA 0.04259 mg/L PBTK NA 50% Rat Human +DTXSID6038875 Css NA 0.2314 mg/L PBTK NA 95% Rat Human +DTXSID6038877 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6038877 Fup 0.028 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6038877 Vd NA 0.9701 L/kg 1compartment NA NA Human Human DTXSID6038877 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6038877 TK.Half.Life NA 12 hours 1compartment NA NA Human Human -DTXSID6038877 Css NA 0.764 mg/L 3compartmentss NA 50% Human Human -DTXSID6038877 Css NA 6.368 mg/L 3compartmentss NA 95% Human Human -DTXSID6038877 Css NA 0.4932 mg/L PBTK NA 50% Human Human -DTXSID6038877 Css NA 3.957 mg/L PBTK NA 95% Human Human -DTXSID6038877 Clint NA 48.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6038877 Fup NA 0.0184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6038877 Vd NA 1.606 L/kg 1compartment NA NA Rat Human +DTXSID6038877 TK.Half.Life NA 6.589 hours 1compartment NA NA Human Human +DTXSID6038877 Css NA 1.049 mg/L 3compartmentss NA 50% Human Human +DTXSID6038877 Css NA 9.91 mg/L 3compartmentss NA 95% Human Human +DTXSID6038877 Css NA 0.6458 mg/L PBTK NA 50% Human Human +DTXSID6038877 Css NA 5.983 mg/L PBTK NA 95% Human Human +DTXSID6038877 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6038877 Fup 0.028 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6038877 Vd NA 0.7293 L/kg 1compartment NA NA Rat Human DTXSID6038877 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6038877 TK.Half.Life NA 3.642 hours 1compartment NA NA Rat Human -DTXSID6038877 Css NA 0.4274 mg/L 3compartmentss NA 50% Rat Human -DTXSID6038877 Css NA 3.041 mg/L 3compartmentss NA 95% Rat Human -DTXSID6038877 Css NA 0.2621 mg/L PBTK NA 50% Rat Human -DTXSID6038877 Css NA 1.772 mg/L PBTK NA 95% Rat Human +DTXSID6038877 TK.Half.Life NA 2.912 hours 1compartment NA NA Rat Human +DTXSID6038877 Css NA 0.1378 mg/L 3compartmentss NA 50% Rat Human +DTXSID6038877 Css NA 0.9951 mg/L 3compartmentss NA 95% Rat Human +DTXSID6038877 Css NA 0.08168 mg/L PBTK NA 50% Rat Human +DTXSID6038877 Css NA 0.575 mg/L PBTK NA 95% Rat Human DTXSID6040115 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6040115 Fup NA 0.545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040115 Vd NA 1.087 L/kg 1compartment NA NA Human Human -DTXSID6040115 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6040115 TK.Half.Life NA 14.23 hours 1compartment NA NA Human Human -DTXSID6040115 Css NA 1.388 mg/L 3compartmentss NA 50% Human Human -DTXSID6040115 Css NA 8.738 mg/L 3compartmentss NA 95% Human Human -DTXSID6040115 Css NA 1.137 mg/L PBTK NA 50% Human Human -DTXSID6040115 Css NA 5.681 mg/L PBTK NA 95% Human Human +DTXSID6040115 Vd NA 0.734 L/kg 1compartment NA NA Human Human +DTXSID6040115 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6040115 TK.Half.Life NA 8.938 hours 1compartment NA NA Human Human +DTXSID6040115 Css NA 1.17 mg/L 3compartmentss NA 50% Human Human +DTXSID6040115 Css NA 7.23 mg/L 3compartmentss NA 95% Human Human +DTXSID6040115 Css NA 0.9122 mg/L PBTK NA 50% Human Human +DTXSID6040115 Css NA 4.616 mg/L PBTK NA 95% Human Human DTXSID6040115 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6040115 Fup NA 0.545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040115 Vd NA 0.9417 L/kg 1compartment NA NA Rat Human +DTXSID6040115 Vd NA 0.6843 L/kg 1compartment NA NA Rat Human DTXSID6040115 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040115 TK.Half.Life NA 3.903 hours 1compartment NA NA Rat Human -DTXSID6040115 Css NA 0.3715 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040115 Css NA 1.974 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040115 Css NA 0.292 mg/L PBTK NA 50% Rat Human -DTXSID6040115 Css NA 1.185 mg/L PBTK NA 95% Rat Human -DTXSID6040246 Clint NA 1.063 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040246 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040246 Vd NA 0.2966 L/kg 1compartment NA NA Human Human -DTXSID6040246 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID6040246 TK.Half.Life NA 54.07 hours 1compartment NA NA Human Human -DTXSID6040246 Css NA 32.24 mg/L 3compartmentss NA 50% Human Human -DTXSID6040246 Css NA 221.4 mg/L 3compartmentss NA 95% Human Human -DTXSID6040246 Css NA 18.98 mg/L PBTK NA 50% Human Human -DTXSID6040246 Css NA 127.6 mg/L PBTK NA 95% Human Human -DTXSID6040246 Clint NA 1.063 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040246 Fup NA 0.0124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040246 Vd NA 0.2489 L/kg 1compartment NA NA Rat Human -DTXSID6040246 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6040246 TK.Half.Life NA 23.12 hours 1compartment NA NA Rat Human -DTXSID6040246 Css NA 13.72 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040246 Css NA 78.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040246 Css NA 7.523 mg/L PBTK NA 50% Rat Human -DTXSID6040246 Css NA 42.72 mg/L PBTK NA 95% Rat Human -DTXSID6040290 Clint NA 97.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040290 Fup NA 0.0719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040290 Vd NA 1.798 L/kg 1compartment NA NA Human Human +DTXSID6040115 TK.Half.Life NA 2.785 hours 1compartment NA NA Rat Human +DTXSID6040115 Css NA 0.022 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040115 Css NA 0.18 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040115 Css NA 0.01658 mg/L PBTK NA 50% Rat Human +DTXSID6040115 Css NA 0.1134 mg/L PBTK NA 95% Rat Human +DTXSID6040246 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040246 Fup 0.0364 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040246 Vd NA 0.4592 L/kg 1compartment NA NA Human Human +DTXSID6040246 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6040246 TK.Half.Life NA 7.272 hours 1compartment NA NA Human Human +DTXSID6040246 Css NA 2.821 mg/L 3compartmentss NA 50% Human Human +DTXSID6040246 Css NA 20.52 mg/L 3compartmentss NA 95% Human Human +DTXSID6040246 Css NA 1.691 mg/L PBTK NA 50% Human Human +DTXSID6040246 Css NA 12.14 mg/L PBTK NA 95% Human Human +DTXSID6040246 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040246 Fup 0.0364 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040246 Vd NA 0.3723 L/kg 1compartment NA NA Rat Human +DTXSID6040246 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6040246 TK.Half.Life NA 3.65 hours 1compartment NA NA Rat Human +DTXSID6040246 Css NA 0.3552 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040246 Css NA 1.894 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040246 Css NA 0.2076 mg/L PBTK NA 50% Rat Human +DTXSID6040246 Css NA 1.078 mg/L PBTK NA 95% Rat Human +DTXSID6040290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040290 Fup 0.0972 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040290 Vd NA 2.007 L/kg 1compartment NA NA Human Human DTXSID6040290 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6040290 TK.Half.Life NA 2.759 hours 1compartment NA NA Human Human -DTXSID6040290 Css NA 0.1089 mg/L 3compartmentss NA 50% Human Human -DTXSID6040290 Css NA 0.8497 mg/L 3compartmentss NA 95% Human Human -DTXSID6040290 Css NA 0.07158 mg/L PBTK NA 50% Human Human -DTXSID6040290 Css NA 0.5401 mg/L PBTK NA 95% Human Human -DTXSID6040290 Clint NA 97.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040290 Fup NA 0.0719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040290 Vd NA 1.356 L/kg 1compartment NA NA Rat Human +DTXSID6040290 TK.Half.Life NA 6.802 hours 1compartment NA NA Human Human +DTXSID6040290 Css NA 0.3755 mg/L 3compartmentss NA 50% Human Human +DTXSID6040290 Css NA 2.697 mg/L 3compartmentss NA 95% Human Human +DTXSID6040290 Css NA 0.2523 mg/L PBTK NA 50% Human Human +DTXSID6040290 Css NA 1.745 mg/L PBTK NA 95% Human Human +DTXSID6040290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040290 Fup 0.0972 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040290 Vd NA 1.519 L/kg 1compartment NA NA Rat Human DTXSID6040290 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040290 TK.Half.Life NA 0.9541 hours 1compartment NA NA Rat Human -DTXSID6040290 Css NA 0.06163 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040290 Css NA 0.3692 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040290 Css NA 0.03857 mg/L PBTK NA 50% Rat Human -DTXSID6040290 Css NA 0.2215 mg/L PBTK NA 95% Rat Human -DTXSID6040296 Clint NA 2.108 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040296 Fup NA 0.0159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040296 Vd NA 0.2556 L/kg 1compartment NA NA Human Human -DTXSID6040296 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6040296 TK.Half.Life NA 23.2 hours 1compartment NA NA Human Human -DTXSID6040296 Css NA 16.11 mg/L 3compartmentss NA 50% Human Human -DTXSID6040296 Css NA 118.6 mg/L 3compartmentss NA 95% Human Human -DTXSID6040296 Css NA 9.631 mg/L PBTK NA 50% Human Human -DTXSID6040296 Css NA 69.88 mg/L PBTK NA 95% Human Human -DTXSID6040296 Clint NA 2.108 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040296 Fup NA 0.0159 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040296 Vd NA 0.2472 L/kg 1compartment NA NA Rat Human -DTXSID6040296 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6040296 TK.Half.Life NA 12.71 hours 1compartment NA NA Rat Human -DTXSID6040296 Css NA 7.734 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040296 Css NA 45.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040296 Css NA 4.315 mg/L PBTK NA 50% Rat Human -DTXSID6040296 Css NA 24.75 mg/L PBTK NA 95% Rat Human -DTXSID6040371 Clint NA 0.05624 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040371 Fup NA 0.2011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040371 Vd NA 0.3138 L/kg 1compartment NA NA Human Human +DTXSID6040290 TK.Half.Life NA 2.25 hours 1compartment NA NA Rat Human +DTXSID6040290 Css NA 0.04829 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040290 Css NA 0.2749 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040290 Css NA 0.03205 mg/L PBTK NA 50% Rat Human +DTXSID6040290 Css NA 0.1747 mg/L PBTK NA 95% Rat Human +DTXSID6040296 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040296 Fup 0.0584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040296 Vd NA 0.4242 L/kg 1compartment NA NA Human Human +DTXSID6040296 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID6040296 TK.Half.Life NA 47.06 hours 1compartment NA NA Human Human +DTXSID6040296 Css NA 16.95 mg/L 3compartmentss NA 50% Human Human +DTXSID6040296 Css NA 80.31 mg/L 3compartmentss NA 95% Human Human +DTXSID6040296 Css NA 10.82 mg/L PBTK NA 50% Human Human +DTXSID6040296 Css NA 47.8 mg/L PBTK NA 95% Human Human +DTXSID6040296 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040296 Fup 0.0584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040296 Vd NA 0.4133 L/kg 1compartment NA NA Rat Human +DTXSID6040296 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6040296 TK.Half.Life NA 15.61 hours 1compartment NA NA Rat Human +DTXSID6040296 Css NA 1.103 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040296 Css NA 4.353 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040296 Css NA 0.6849 mg/L PBTK NA 50% Rat Human +DTXSID6040296 Css NA 2.507 mg/L PBTK NA 95% Rat Human +DTXSID6040371 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040371 Fup 0.555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040371 Vd NA 0.4705 L/kg 1compartment NA NA Human Human DTXSID6040371 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6040371 TK.Half.Life NA 9.232 hours 1compartment NA NA Human Human -DTXSID6040371 Css NA 3.612 mg/L 3compartmentss NA 50% Human Human -DTXSID6040371 Css NA 12.85 mg/L 3compartmentss NA 95% Human Human -DTXSID6040371 Css NA 2.359 mg/L PBTK NA 50% Human Human -DTXSID6040371 Css NA 7.825 mg/L PBTK NA 95% Human Human -DTXSID6040371 Clint NA 0.05624 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040371 Fup NA 0.2011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040371 Vd NA 0.3146 L/kg 1compartment NA NA Rat Human +DTXSID6040371 TK.Half.Life NA 0.7575 hours 1compartment NA NA Human Human +DTXSID6040371 Css NA 0.125 mg/L 3compartmentss NA 50% Human Human +DTXSID6040371 Css NA 1.113 mg/L 3compartmentss NA 95% Human Human +DTXSID6040371 Css NA 0.09166 mg/L PBTK NA 50% Human Human +DTXSID6040371 Css NA 0.7165 mg/L PBTK NA 95% Human Human +DTXSID6040371 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040371 Fup 0.555 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040371 Vd NA 0.4789 L/kg 1compartment NA NA Rat Human DTXSID6040371 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040371 TK.Half.Life NA 3.299 hours 1compartment NA NA Rat Human -DTXSID6040371 Css NA 1.078 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040371 Css NA 3.276 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040371 Css NA 0.6585 mg/L PBTK NA 50% Rat Human -DTXSID6040371 Css NA 1.853 mg/L PBTK NA 95% Rat Human -DTXSID6040373 Clint NA 25.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040373 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040373 Vd NA 4.389 L/kg 1compartment NA NA Human Human -DTXSID6040373 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID6040373 TK.Half.Life NA 113.8 hours 1compartment NA NA Human Human -DTXSID6040373 Css NA 2.746 mg/L 3compartmentss NA 50% Human Human -DTXSID6040373 Css NA 15.23 mg/L 3compartmentss NA 95% Human Human -DTXSID6040373 Css NA 2.115 mg/L PBTK NA 50% Human Human -DTXSID6040373 Css NA 11.66 mg/L PBTK NA 95% Human Human -DTXSID6040373 Clint NA 25.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040373 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040373 Vd NA 3.333 L/kg 1compartment NA NA Rat Human -DTXSID6040373 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID6040373 TK.Half.Life NA 16.49 hours 1compartment NA NA Rat Human -DTXSID6040373 Css NA 1.534 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040373 Css NA 6.508 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040373 Css NA 1.136 mg/L PBTK NA 50% Rat Human -DTXSID6040373 Css NA 4.932 mg/L PBTK NA 95% Rat Human -DTXSID6040375 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040375 Fup NA 0.9528 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040375 Vd NA 0.8358 L/kg 1compartment NA NA Human Human +DTXSID6040371 TK.Half.Life NA 0.4163 hours 1compartment NA NA Rat Human +DTXSID6040371 Css NA 0.01432 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040371 Css NA 0.1054 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040371 Css NA 0.01049 mg/L PBTK NA 50% Rat Human +DTXSID6040371 Css NA 0.06462 mg/L PBTK NA 95% Rat Human +DTXSID6040373 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040373 Fup 0.0085 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040373 Vd NA 3.029 L/kg 1compartment NA NA Human Human +DTXSID6040373 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID6040373 TK.Half.Life NA 80.57 hours 1compartment NA NA Human Human +DTXSID6040373 Css NA 3.292 mg/L 3compartmentss NA 50% Human Human +DTXSID6040373 Css NA 21.88 mg/L 3compartmentss NA 95% Human Human +DTXSID6040373 Css NA 2.27 mg/L PBTK NA 50% Human Human +DTXSID6040373 Css NA 14.84 mg/L PBTK NA 95% Human Human +DTXSID6040373 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040373 Fup 0.0085 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040373 Vd NA 2.267 L/kg 1compartment NA NA Rat Human +DTXSID6040373 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID6040373 TK.Half.Life NA 12.23 hours 1compartment NA NA Rat Human +DTXSID6040373 Css NA 0.4286 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040373 Css NA 2.381 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040373 Css NA 0.2906 mg/L PBTK NA 50% Rat Human +DTXSID6040373 Css NA 1.564 mg/L PBTK NA 95% Rat Human +DTXSID6040375 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040375 Fup 0.586 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040375 Vd NA 0.6811 L/kg 1compartment NA NA Human Human DTXSID6040375 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6040375 TK.Half.Life NA 5.691 hours 1compartment NA NA Human Human -DTXSID6040375 Css NA 0.8758 mg/L 3compartmentss NA 50% Human Human -DTXSID6040375 Css NA 4.867 mg/L 3compartmentss NA 95% Human Human -DTXSID6040375 Css NA 0.744 mg/L PBTK NA 50% Human Human -DTXSID6040375 Css NA 3.216 mg/L PBTK NA 95% Human Human -DTXSID6040375 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040375 Fup NA 0.9528 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040375 Vd NA 0.8607 L/kg 1compartment NA NA Rat Human +DTXSID6040375 TK.Half.Life NA 7.55 hours 1compartment NA NA Human Human +DTXSID6040375 Css NA 1.069 mg/L 3compartmentss NA 50% Human Human +DTXSID6040375 Css NA 7.331 mg/L 3compartmentss NA 95% Human Human +DTXSID6040375 Css NA 0.8531 mg/L PBTK NA 50% Human Human +DTXSID6040375 Css NA 4.641 mg/L PBTK NA 95% Human Human +DTXSID6040375 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040375 Fup 0.586 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040375 Vd NA 0.6888 L/kg 1compartment NA NA Rat Human DTXSID6040375 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040375 TK.Half.Life NA 1.992 hours 1compartment NA NA Rat Human -DTXSID6040375 Css NA 0.2231 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040375 Css NA 1.263 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040375 Css NA 0.1845 mg/L PBTK NA 50% Rat Human -DTXSID6040375 Css NA 0.7692 mg/L PBTK NA 95% Rat Human -DTXSID6040583 Clint NA 9.166 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040583 Fup NA 0.0717 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040583 Vd NA 2.973 L/kg 1compartment NA NA Human Human -DTXSID6040583 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6040583 TK.Half.Life NA 16.89 hours 1compartment NA NA Human Human -DTXSID6040583 Css NA 0.5822 mg/L 3compartmentss NA 50% Human Human -DTXSID6040583 Css NA 3.625 mg/L 3compartmentss NA 95% Human Human -DTXSID6040583 Css NA 0.4613 mg/L PBTK NA 50% Human Human -DTXSID6040583 Css NA 2.685 mg/L PBTK NA 95% Human Human -DTXSID6040583 Clint NA 9.166 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040583 Fup NA 0.0717 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040583 Vd NA 2.512 L/kg 1compartment NA NA Rat Human +DTXSID6040375 TK.Half.Life NA 2.595 hours 1compartment NA NA Rat Human +DTXSID6040375 Css NA 0.02039 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040375 Css NA 0.1825 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040375 Css NA 0.01564 mg/L PBTK NA 50% Rat Human +DTXSID6040375 Css NA 0.1141 mg/L PBTK NA 95% Rat Human +DTXSID6040404 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040404 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040404 Vd NA 4.962 L/kg 1compartment NA NA Human Human +DTXSID6040404 Days.Css NA 23 Days PBTK NA NA Human Human +DTXSID6040404 TK.Half.Life NA 133.2 hours 1compartment NA NA Human Human +DTXSID6040404 Css NA 2.746 mg/L 3compartmentss NA 50% Human Human +DTXSID6040404 Css NA 18.52 mg/L 3compartmentss NA 95% Human Human +DTXSID6040404 Css NA 2.21 mg/L PBTK NA 50% Human Human +DTXSID6040404 Css NA 14.15 mg/L PBTK NA 95% Human Human +DTXSID6040404 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040404 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040404 Vd NA 3.787 L/kg 1compartment NA NA Rat Human +DTXSID6040404 Days.Css NA 14 Days PBTK NA NA Rat Human +DTXSID6040404 TK.Half.Life NA 18.47 hours 1compartment NA NA Rat Human +DTXSID6040404 Css NA 0.3538 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040404 Css NA 1.949 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040404 Css NA 0.2861 mg/L PBTK NA 50% Rat Human +DTXSID6040404 Css NA 1.499 mg/L PBTK NA 95% Rat Human +DTXSID6040531 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040531 Fup 0.0717 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040531 Vd NA 0.3738 L/kg 1compartment NA NA Human Human +DTXSID6040531 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6040531 TK.Half.Life NA 3.245 hours 1compartment NA NA Human Human +DTXSID6040531 Css NA 1.038 mg/L 3compartmentss NA 50% Human Human +DTXSID6040531 Css NA 6.272 mg/L 3compartmentss NA 95% Human Human +DTXSID6040531 Css NA 0.6684 mg/L PBTK NA 50% Human Human +DTXSID6040531 Css NA 3.837 mg/L PBTK NA 95% Human Human +DTXSID6040531 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040531 Fup 0.0717 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040531 Vd NA 0.365 L/kg 1compartment NA NA Rat Human +DTXSID6040531 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6040531 TK.Half.Life NA 1.961 hours 1compartment NA NA Rat Human +DTXSID6040531 Css NA 0.07808 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040531 Css NA 0.405 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040531 Css NA 0.0493 mg/L PBTK NA 50% Rat Human +DTXSID6040531 Css NA 0.2399 mg/L PBTK NA 95% Rat Human +DTXSID6040537 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040537 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6040537 Vd NA 0.7615 L/kg 1compartment NA NA Human Human +DTXSID6040537 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6040537 TK.Half.Life NA 0.7902 hours 1compartment NA NA Human Human +DTXSID6040537 Css NA 0.03471 mg/L 3compartmentss NA 50% Human Human +DTXSID6040537 Css NA 0.4105 mg/L 3compartmentss NA 95% Human Human +DTXSID6040537 Css NA 0.02874 mg/L PBTK NA 50% Human Human +DTXSID6040537 Css NA 0.2937 mg/L PBTK NA 95% Human Human +DTXSID6040537 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040537 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6040537 Vd NA 0.8003 L/kg 1compartment NA NA Rat Human +DTXSID6040537 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6040537 TK.Half.Life NA 0.4281 hours 1compartment NA NA Rat Human +DTXSID6040537 Css NA 0.0002867 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040537 Css NA 0.003143 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040537 Css NA 0.000234 mg/L PBTK NA 50% Rat Human +DTXSID6040537 Css NA 0.00219 mg/L PBTK NA 95% Rat Human +DTXSID6040583 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040583 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040583 Vd NA 1.032 L/kg 1compartment NA NA Human Human +DTXSID6040583 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6040583 TK.Half.Life NA 1.399 hours 1compartment NA NA Human Human +DTXSID6040583 Css NA 0.0732 mg/L 3compartmentss NA 50% Human Human +DTXSID6040583 Css NA 0.5532 mg/L 3compartmentss NA 95% Human Human +DTXSID6040583 Css NA 0.0551 mg/L PBTK NA 50% Human Human +DTXSID6040583 Css NA 0.3781 mg/L PBTK NA 95% Human Human +DTXSID6040583 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040583 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040583 Vd NA 1.035 L/kg 1compartment NA NA Rat Human DTXSID6040583 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040583 TK.Half.Life NA 5.752 hours 1compartment NA NA Rat Human -DTXSID6040583 Css NA 0.3162 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040583 Css NA 1.512 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040583 Css NA 0.241 mg/L PBTK NA 50% Rat Human -DTXSID6040583 Css NA 1.064 mg/L PBTK NA 95% Rat Human +DTXSID6040583 TK.Half.Life NA 0.7649 hours 1compartment NA NA Rat Human +DTXSID6040583 Css NA 0.009316 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040583 Css NA 0.05282 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040583 Css NA 0.006951 mg/L PBTK NA 50% Rat Human +DTXSID6040583 Css NA 0.03495 mg/L PBTK NA 95% Rat Human DTXSID6040614 Clint NA 0.0001303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6040614 Fup NA 0.5033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040614 Vd NA 0.5449 L/kg 1compartment NA NA Human Human +DTXSID6040614 Vd NA 0.5762 L/kg 1compartment NA NA Human Human DTXSID6040614 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6040614 TK.Half.Life NA 7.002 hours 1compartment NA NA Human Human -DTXSID6040614 Css NA 1.458 mg/L 3compartmentss NA 50% Human Human -DTXSID6040614 Css NA 7.522 mg/L 3compartmentss NA 95% Human Human -DTXSID6040614 Css NA 1.102 mg/L PBTK NA 50% Human Human -DTXSID6040614 Css NA 4.719 mg/L PBTK NA 95% Human Human +DTXSID6040614 TK.Half.Life NA 7.405 hours 1compartment NA NA Human Human +DTXSID6040614 Css NA 1.212 mg/L 3compartmentss NA 50% Human Human +DTXSID6040614 Css NA 6.418 mg/L 3compartmentss NA 95% Human Human +DTXSID6040614 Css NA 0.9382 mg/L PBTK NA 50% Human Human +DTXSID6040614 Css NA 4.055 mg/L PBTK NA 95% Human Human DTXSID6040614 Clint NA 0.0001303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6040614 Fup NA 0.5033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040614 Vd NA 0.5644 L/kg 1compartment NA NA Rat Human +DTXSID6040614 Vd NA 0.5927 L/kg 1compartment NA NA Rat Human DTXSID6040614 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040614 TK.Half.Life NA 2.473 hours 1compartment NA NA Rat Human -DTXSID6040614 Css NA 0.3968 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040614 Css NA 1.883 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040614 Css NA 0.2875 mg/L PBTK NA 50% Rat Human -DTXSID6040614 Css NA 1.107 mg/L PBTK NA 95% Rat Human -DTXSID6040662 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040662 Fup NA 0.0019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040662 Vd NA 1.783 L/kg 1compartment NA NA Human Human -DTXSID6040662 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6040662 TK.Half.Life NA 19.4 hours 1compartment NA NA Human Human -DTXSID6040662 Css NA 1.735 mg/L 3compartmentss NA 50% Human Human -DTXSID6040662 Css NA 14.61 mg/L 3compartmentss NA 95% Human Human -DTXSID6040662 Css NA 1.077 mg/L PBTK NA 50% Human Human -DTXSID6040662 Css NA 8.998 mg/L PBTK NA 95% Human Human -DTXSID6040662 Clint NA 76.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040662 Fup NA 0.0019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040662 Vd NA 1.312 L/kg 1compartment NA NA Rat Human -DTXSID6040662 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6040662 TK.Half.Life NA 6.789 hours 1compartment NA NA Rat Human -DTXSID6040662 Css NA 0.9784 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040662 Css NA 6.614 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040662 Css NA 0.5742 mg/L PBTK NA 50% Rat Human -DTXSID6040662 Css NA 3.76 mg/L PBTK NA 95% Rat Human -DTXSID6040664 Clint NA 13.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040664 Fup NA 0.1635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040664 Vd NA 2.129 L/kg 1compartment NA NA Human Human +DTXSID6040614 TK.Half.Life NA 2.597 hours 1compartment NA NA Rat Human +DTXSID6040614 Css NA 0.02268 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040614 Css NA 0.1585 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040614 Css NA 0.01695 mg/L PBTK NA 50% Rat Human +DTXSID6040614 Css NA 0.1009 mg/L PBTK NA 95% Rat Human +DTXSID6040618 Clint 5.37 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040618 Fup 0.013 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040618 Vd NA 2.978 L/kg 1compartment NA NA Human Human +DTXSID6040618 Days.Css NA 56 Days PBTK NA NA Human Human +DTXSID6040618 TK.Half.Life NA 258.6 hours 1compartment NA NA Human Human +DTXSID6040618 Css NA 11.18 mg/L 3compartmentss NA 50% Human Human +DTXSID6040618 Css NA 71.63 mg/L 3compartmentss NA 95% Human Human +DTXSID6040618 Css NA 7.645 mg/L PBTK NA 50% Human Human +DTXSID6040618 Css NA 47.51 mg/L PBTK NA 95% Human Human +DTXSID6040618 Clint 5.37 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040618 Fup 0.013 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040618 Vd NA 2.228 L/kg 1compartment NA NA Rat Human +DTXSID6040618 Days.Css NA 30 Days PBTK NA NA Rat Human +DTXSID6040618 TK.Half.Life NA 40.18 hours 1compartment NA NA Rat Human +DTXSID6040618 Css NA 1.446 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040618 Css NA 7.47 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040618 Css NA 0.9762 mg/L PBTK NA 50% Rat Human +DTXSID6040618 Css NA 4.857 mg/L PBTK NA 95% Rat Human +DTXSID6040662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040662 Fup 0.0636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040662 Vd NA 0.4746 L/kg 1compartment NA NA Human Human +DTXSID6040662 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6040662 TK.Half.Life NA 1.69 hours 1compartment NA NA Human Human +DTXSID6040662 Css NA 0.466 mg/L 3compartmentss NA 50% Human Human +DTXSID6040662 Css NA 3.894 mg/L 3compartmentss NA 95% Human Human +DTXSID6040662 Css NA 0.284 mg/L PBTK NA 50% Human Human +DTXSID6040662 Css NA 2.322 mg/L PBTK NA 95% Human Human +DTXSID6040662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040662 Fup 0.0636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040662 Vd NA 0.3999 L/kg 1compartment NA NA Rat Human +DTXSID6040662 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6040662 TK.Half.Life NA 0.8662 hours 1compartment NA NA Rat Human +DTXSID6040662 Css NA 0.06094 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040662 Css NA 0.378 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040662 Css NA 0.03616 mg/L PBTK NA 50% Rat Human +DTXSID6040662 Css NA 0.2194 mg/L PBTK NA 95% Rat Human +DTXSID6040664 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040664 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040664 Vd NA 2.121 L/kg 1compartment NA NA Human Human DTXSID6040664 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6040664 TK.Half.Life NA 7.548 hours 1compartment NA NA Human Human -DTXSID6040664 Css NA 0.3609 mg/L 3compartmentss NA 50% Human Human -DTXSID6040664 Css NA 2.353 mg/L 3compartmentss NA 95% Human Human -DTXSID6040664 Css NA 0.257 mg/L PBTK NA 50% Human Human -DTXSID6040664 Css NA 1.586 mg/L PBTK NA 95% Human Human -DTXSID6040664 Clint NA 13.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040664 Fup NA 0.1635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040664 Vd NA 1.627 L/kg 1compartment NA NA Rat Human +DTXSID6040664 TK.Half.Life NA 5.134 hours 1compartment NA NA Human Human +DTXSID6040664 Css NA 0.197 mg/L 3compartmentss NA 50% Human Human +DTXSID6040664 Css NA 1.372 mg/L 3compartmentss NA 95% Human Human +DTXSID6040664 Css NA 0.1408 mg/L PBTK NA 50% Human Human +DTXSID6040664 Css NA 0.9336 mg/L PBTK NA 95% Human Human +DTXSID6040664 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040664 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040664 Vd NA 1.622 L/kg 1compartment NA NA Rat Human DTXSID6040664 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040664 TK.Half.Life NA 2.403 hours 1compartment NA NA Rat Human -DTXSID6040664 Css NA 0.1974 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040664 Css NA 0.9047 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040664 Css NA 0.1342 mg/L PBTK NA 50% Rat Human -DTXSID6040664 Css NA 0.5762 mg/L PBTK NA 95% Rat Human -DTXSID6040666 Clint NA 0.5947 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040666 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040666 Vd NA 0.8193 L/kg 1compartment NA NA Human Human +DTXSID6040664 TK.Half.Life NA 1.666 hours 1compartment NA NA Rat Human +DTXSID6040664 Css NA 0.02513 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040664 Css NA 0.1264 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040664 Css NA 0.01781 mg/L PBTK NA 50% Rat Human +DTXSID6040664 Css NA 0.08603 mg/L PBTK NA 95% Rat Human +DTXSID6040666 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040666 Fup 0.753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040666 Vd NA 0.6934 L/kg 1compartment NA NA Human Human DTXSID6040666 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6040666 TK.Half.Life NA 2.789 hours 1compartment NA NA Human Human -DTXSID6040666 Css NA 0.4146 mg/L 3compartmentss NA 50% Human Human -DTXSID6040666 Css NA 2.838 mg/L 3compartmentss NA 95% Human Human -DTXSID6040666 Css NA 0.3508 mg/L PBTK NA 50% Human Human -DTXSID6040666 Css NA 1.875 mg/L PBTK NA 95% Human Human -DTXSID6040666 Clint NA 0.5947 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040666 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040666 Vd NA 0.8518 L/kg 1compartment NA NA Rat Human +DTXSID6040666 TK.Half.Life NA 5.965 hours 1compartment NA NA Human Human +DTXSID6040666 Css NA 1.013 mg/L 3compartmentss NA 50% Human Human +DTXSID6040666 Css NA 6.158 mg/L 3compartmentss NA 95% Human Human +DTXSID6040666 Css NA 0.82 mg/L PBTK NA 50% Human Human +DTXSID6040666 Css NA 3.888 mg/L PBTK NA 95% Human Human +DTXSID6040666 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040666 Fup 0.753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040666 Vd NA 0.7205 L/kg 1compartment NA NA Rat Human DTXSID6040666 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040666 TK.Half.Life NA 1.294 hours 1compartment NA NA Rat Human -DTXSID6040666 Css NA 0.1405 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040666 Css NA 0.9167 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040666 Css NA 0.1179 mg/L PBTK NA 50% Rat Human -DTXSID6040666 Css NA 0.555 mg/L PBTK NA 95% Rat Human -DTXSID6040668 Clint NA 226.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6040666 TK.Half.Life NA 2.11 hours 1compartment NA NA Rat Human +DTXSID6040666 Css NA 0.06001 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040666 Css NA 0.3766 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040666 Css NA 0.04878 mg/L PBTK NA 50% Rat Human +DTXSID6040666 Css NA 0.2308 mg/L PBTK NA 95% Rat Human +DTXSID6040668 Clint 28 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID6040668 Fup 0.009 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6040668 Vd NA 0.256 L/kg 1compartment NA NA Human Human +DTXSID6040668 Vd NA 0.2188 L/kg 1compartment NA NA Human Human DTXSID6040668 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6040668 TK.Half.Life NA 0.7135 hours 1compartment NA NA Human Human -DTXSID6040668 Css NA 0.3472 mg/L 3compartmentss NA 50% Human Human -DTXSID6040668 Css NA 3.594 mg/L 3compartmentss NA 95% Human Human -DTXSID6040668 Css NA 0.203 mg/L PBTK NA 50% Human Human -DTXSID6040668 Css NA 2.098 mg/L PBTK NA 95% Human Human -DTXSID6040668 Clint NA 226.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6040668 TK.Half.Life NA 3.418 hours 1compartment NA NA Human Human +DTXSID6040668 Css NA 2.415 mg/L 3compartmentss NA 50% Human Human +DTXSID6040668 Css NA 25.66 mg/L 3compartmentss NA 95% Human Human +DTXSID6040668 Css NA 1.414 mg/L PBTK NA 50% Human Human +DTXSID6040668 Css NA 15.09 mg/L PBTK NA 95% Human Human +DTXSID6040668 Clint 28 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID6040668 Fup 0.009 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6040668 Vd NA 0.2248 L/kg 1compartment NA NA Rat Human +DTXSID6040668 Vd NA 0.2015 L/kg 1compartment NA NA Rat Human DTXSID6040668 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040668 TK.Half.Life NA 0.3798 hours 1compartment NA NA Rat Human -DTXSID6040668 Css NA 0.2027 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040668 Css NA 1.912 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040668 Css NA 0.1105 mg/L PBTK NA 50% Rat Human -DTXSID6040668 Css NA 1.035 mg/L PBTK NA 95% Rat Human -DTXSID6040743 Clint NA 13.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040743 Fup NA 0.0018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040743 Vd NA 3.529 L/kg 1compartment NA NA Human Human -DTXSID6040743 Days.Css NA 41 Days PBTK NA NA Human Human -DTXSID6040743 TK.Half.Life NA 204.2 hours 1compartment NA NA Human Human -DTXSID6040743 Css NA 8.782 mg/L 3compartmentss NA 50% Human Human -DTXSID6040743 Css NA 77.59 mg/L 3compartmentss NA 95% Human Human -DTXSID6040743 Css NA 6.152 mg/L PBTK NA 50% Human Human -DTXSID6040743 Css NA 49.98 mg/L PBTK NA 95% Human Human -DTXSID6040743 Clint NA 13.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040743 Fup NA 0.0018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040743 Vd NA 2.658 L/kg 1compartment NA NA Rat Human -DTXSID6040743 Days.Css NA 22 Days PBTK NA NA Rat Human -DTXSID6040743 TK.Half.Life NA 75.42 hours 1compartment NA NA Rat Human -DTXSID6040743 Css NA 4.897 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040743 Css NA 34.66 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040743 Css NA 3.285 mg/L PBTK NA 50% Rat Human -DTXSID6040743 Css NA 21.06 mg/L PBTK NA 95% Rat Human -DTXSID6040745 Clint NA 139.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040745 Fup NA 0.018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040745 Vd NA 0.3184 L/kg 1compartment NA NA Human Human -DTXSID6040745 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6040745 TK.Half.Life NA 0.7725 hours 1compartment NA NA Human Human -DTXSID6040745 Css NA 0.283 mg/L 3compartmentss NA 50% Human Human -DTXSID6040745 Css NA 2.969 mg/L 3compartmentss NA 95% Human Human -DTXSID6040745 Css NA 0.1702 mg/L PBTK NA 50% Human Human -DTXSID6040745 Css NA 1.761 mg/L PBTK NA 95% Human Human -DTXSID6040745 Clint NA 139.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040745 Fup NA 0.018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040745 Vd NA 0.2885 L/kg 1compartment NA NA Rat Human +DTXSID6040668 TK.Half.Life NA 2.11 hours 1compartment NA NA Rat Human +DTXSID6040668 Css NA 0.1248 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040668 Css NA 1.364 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040668 Css NA 0.06946 mg/L PBTK NA 50% Rat Human +DTXSID6040668 Css NA 0.7594 mg/L PBTK NA 95% Rat Human +DTXSID60406887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60406887 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60406887 Vd NA 0.4924 L/kg 1compartment NA NA Human Human +DTXSID60406887 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60406887 TK.Half.Life NA 0.6564 hours 1compartment NA NA Human Human +DTXSID60406887 Css NA 0.07061 mg/L 3compartmentss NA 50% Human Human +DTXSID60406887 Css NA 0.5264 mg/L 3compartmentss NA 95% Human Human +DTXSID60406887 Css NA 0.04975 mg/L PBTK NA 50% Human Human +DTXSID60406887 Css NA 0.3411 mg/L PBTK NA 95% Human Human +DTXSID60406887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60406887 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60406887 Vd NA 0.4984 L/kg 1compartment NA NA Rat Human +DTXSID60406887 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60406887 TK.Half.Life NA 0.3546 hours 1compartment NA NA Rat Human +DTXSID60406887 Css NA 0.00895 mg/L 3compartmentss NA 50% Rat Human +DTXSID60406887 Css NA 0.05152 mg/L 3compartmentss NA 95% Rat Human +DTXSID60406887 Css NA 0.006261 mg/L PBTK NA 50% Rat Human +DTXSID60406887 Css NA 0.03284 mg/L PBTK NA 95% Rat Human +DTXSID6040743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040743 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040743 Vd NA 6.739 L/kg 1compartment NA NA Human Human +DTXSID6040743 Days.Css NA 20 Days PBTK NA NA Human Human +DTXSID6040743 TK.Half.Life NA 122.3 hours 1compartment NA NA Human Human +DTXSID6040743 Css NA 1.828 mg/L 3compartmentss NA 50% Human Human +DTXSID6040743 Css NA 14.2 mg/L 3compartmentss NA 95% Human Human +DTXSID6040743 Css NA 1.664 mg/L PBTK NA 50% Human Human +DTXSID6040743 Css NA 11.47 mg/L PBTK NA 95% Human Human +DTXSID6040743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040743 Fup 0.0116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040743 Vd NA 5.217 L/kg 1compartment NA NA Rat Human +DTXSID6040743 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID6040743 TK.Half.Life NA 26.23 hours 1compartment NA NA Rat Human +DTXSID6040743 Css NA 0.229 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040743 Css NA 1.538 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040743 Css NA 0.2114 mg/L PBTK NA 50% Rat Human +DTXSID6040743 Css NA 1.291 mg/L PBTK NA 95% Rat Human +DTXSID6040745 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040745 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040745 Vd NA 0.3555 L/kg 1compartment NA NA Human Human +DTXSID6040745 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6040745 TK.Half.Life NA 13.97 hours 1compartment NA NA Human Human +DTXSID6040745 Css NA 6.975 mg/L 3compartmentss NA 50% Human Human +DTXSID6040745 Css NA 59.61 mg/L 3compartmentss NA 95% Human Human +DTXSID6040745 Css NA 4.218 mg/L PBTK NA 50% Human Human +DTXSID6040745 Css NA 34.43 mg/L PBTK NA 95% Human Human +DTXSID6040745 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040745 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040745 Vd NA 0.3105 L/kg 1compartment NA NA Rat Human DTXSID6040745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040745 TK.Half.Life NA 0.4171 hours 1compartment NA NA Rat Human -DTXSID6040745 Css NA 0.1625 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040745 Css NA 1.433 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040745 Css NA 0.09185 mg/L PBTK NA 50% Rat Human -DTXSID6040745 Css NA 0.7852 mg/L PBTK NA 95% Rat Human -DTXSID6040747 Clint NA 7.758 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6040745 TK.Half.Life NA 7.747 hours 1compartment NA NA Rat Human +DTXSID6040745 Css NA 0.8602 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040745 Css NA 5.922 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040745 Css NA 0.5031 mg/L PBTK NA 50% Rat Human +DTXSID6040745 Css NA 3.339 mg/L PBTK NA 95% Rat Human +DTXSID6040747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6040747 Fup 0.0828 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6040747 Vd NA 2.006 L/kg 1compartment NA NA Human Human -DTXSID6040747 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6040747 TK.Half.Life NA 17.72 hours 1compartment NA NA Human Human -DTXSID6040747 Css NA 1.032 mg/L 3compartmentss NA 50% Human Human -DTXSID6040747 Css NA 5.779 mg/L 3compartmentss NA 95% Human Human -DTXSID6040747 Css NA 0.7002 mg/L PBTK NA 50% Human Human -DTXSID6040747 Css NA 3.828 mg/L PBTK NA 95% Human Human -DTXSID6040747 Clint NA 7.758 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6040747 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6040747 TK.Half.Life NA 7.619 hours 1compartment NA NA Human Human +DTXSID6040747 Css NA 0.3729 mg/L 3compartmentss NA 50% Human Human +DTXSID6040747 Css NA 2.413 mg/L 3compartmentss NA 95% Human Human +DTXSID6040747 Css NA 0.255 mg/L PBTK NA 50% Human Human +DTXSID6040747 Css NA 1.568 mg/L PBTK NA 95% Human Human +DTXSID6040747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6040747 Fup 0.0828 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6040747 Vd NA 1.514 L/kg 1compartment NA NA Rat Human DTXSID6040747 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040747 TK.Half.Life NA 5.658 hours 1compartment NA NA Rat Human -DTXSID6040747 Css NA 0.5544 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040747 Css NA 2.299 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040747 Css NA 0.3594 mg/L PBTK NA 50% Rat Human -DTXSID6040747 Css NA 1.423 mg/L PBTK NA 95% Rat Human -DTXSID6040795 Clint NA 0.803 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040795 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6040795 Vd NA 0.3584 L/kg 1compartment NA NA Human Human -DTXSID6040795 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6040795 TK.Half.Life NA 21.51 hours 1compartment NA NA Human Human -DTXSID6040795 Css NA 10.15 mg/L 3compartmentss NA 50% Human Human -DTXSID6040795 Css NA 49.88 mg/L 3compartmentss NA 95% Human Human -DTXSID6040795 Css NA 6.104 mg/L PBTK NA 50% Human Human -DTXSID6040795 Css NA 29.34 mg/L PBTK NA 95% Human Human -DTXSID6040795 Clint NA 0.803 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040795 Fup NA 0.046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6040795 Vd NA 0.3098 L/kg 1compartment NA NA Rat Human +DTXSID6040747 TK.Half.Life NA 2.51 hours 1compartment NA NA Rat Human +DTXSID6040747 Css NA 0.04771 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040747 Css NA 0.242 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040747 Css NA 0.032 mg/L PBTK NA 50% Rat Human +DTXSID6040747 Css NA 0.1604 mg/L PBTK NA 95% Rat Human +DTXSID6040795 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040795 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040795 Vd NA 0.3581 L/kg 1compartment NA NA Human Human +DTXSID6040795 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6040795 TK.Half.Life NA 1.113 hours 1compartment NA NA Human Human +DTXSID6040795 Css NA 0.3032 mg/L 3compartmentss NA 50% Human Human +DTXSID6040795 Css NA 1.775 mg/L 3compartmentss NA 95% Human Human +DTXSID6040795 Css NA 0.1985 mg/L PBTK NA 50% Human Human +DTXSID6040795 Css NA 1.116 mg/L PBTK NA 95% Human Human +DTXSID6040795 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040795 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040795 Vd NA 0.365 L/kg 1compartment NA NA Rat Human DTXSID6040795 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6040795 TK.Half.Life NA 8.932 hours 1compartment NA NA Rat Human -DTXSID6040795 Css NA 4.14 mg/L 3compartmentss NA 50% Rat Human -DTXSID6040795 Css NA 16.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID6040795 Css NA 2.325 mg/L PBTK NA 50% Rat Human -DTXSID6040795 Css NA 8.943 mg/L PBTK NA 95% Rat Human +DTXSID6040795 TK.Half.Life NA 0.6576 hours 1compartment NA NA Rat Human +DTXSID6040795 Css NA 0.03638 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040795 Css NA 0.1572 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040795 Css NA 0.02351 mg/L PBTK NA 50% Rat Human +DTXSID6040795 Css NA 0.09522 mg/L PBTK NA 95% Rat Human +DTXSID6040799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040799 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6040799 Vd NA 3.126 L/kg 1compartment NA NA Human Human +DTXSID6040799 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID6040799 TK.Half.Life NA 93.8 hours 1compartment NA NA Human Human +DTXSID6040799 Css NA 3.406 mg/L 3compartmentss NA 50% Human Human +DTXSID6040799 Css NA 19.84 mg/L 3compartmentss NA 95% Human Human +DTXSID6040799 Css NA 2.375 mg/L PBTK NA 50% Human Human +DTXSID6040799 Css NA 13.78 mg/L PBTK NA 95% Human Human +DTXSID6040799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040799 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6040799 Vd NA 2.341 L/kg 1compartment NA NA Rat Human +DTXSID6040799 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID6040799 TK.Half.Life NA 12.49 hours 1compartment NA NA Rat Human +DTXSID6040799 Css NA 0.4466 mg/L 3compartmentss NA 50% Rat Human +DTXSID6040799 Css NA 2.159 mg/L 3compartmentss NA 95% Rat Human +DTXSID6040799 Css NA 0.3066 mg/L PBTK NA 50% Rat Human +DTXSID6040799 Css NA 1.472 mg/L PBTK NA 95% Rat Human DTXSID6041056 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6041056 Fup NA 0.9945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6041056 Vd NA 0.6594 L/kg 1compartment NA NA Human Human DTXSID6041056 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6041056 TK.Half.Life NA 4.292 hours 1compartment NA NA Human Human -DTXSID6041056 Css NA 0.8862 mg/L 3compartmentss NA 50% Human Human -DTXSID6041056 Css NA 5.182 mg/L 3compartmentss NA 95% Human Human -DTXSID6041056 Css NA 0.7224 mg/L PBTK NA 50% Human Human -DTXSID6041056 Css NA 3.403 mg/L PBTK NA 95% Human Human +DTXSID6041056 Css NA 0.7589 mg/L 3compartmentss NA 50% Human Human +DTXSID6041056 Css NA 4.835 mg/L 3compartmentss NA 95% Human Human +DTXSID6041056 Css NA 0.6156 mg/L PBTK NA 50% Human Human +DTXSID6041056 Css NA 3.147 mg/L PBTK NA 95% Human Human DTXSID6041056 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6041056 Fup NA 0.9945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6041056 Vd NA 0.7171 L/kg 1compartment NA NA Rat Human DTXSID6041056 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6041056 TK.Half.Life NA 1.589 hours 1compartment NA NA Rat Human -DTXSID6041056 Css NA 0.2264 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041056 Css NA 1.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041056 Css NA 0.1786 mg/L PBTK NA 50% Rat Human -DTXSID6041056 Css NA 0.7543 mg/L PBTK NA 95% Rat Human -DTXSID6041133 Clint NA 0.1652 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6041056 Css NA 0.01424 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041056 Css NA 0.1017 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041056 Css NA 0.01113 mg/L PBTK NA 50% Rat Human +DTXSID6041056 Css NA 0.06709 mg/L PBTK NA 95% Rat Human +DTXSID6041133 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6041133 Fup 0.29 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6041133 Vd NA 2.852 L/kg 1compartment NA NA Human Human -DTXSID6041133 Days.Css NA 54 Days PBTK NA NA Human Human -DTXSID6041133 TK.Half.Life NA 255.4 hours 1compartment NA NA Human Human -DTXSID6041133 Css NA 9.774 mg/L 3compartmentss NA 50% Human Human -DTXSID6041133 Css NA 28.06 mg/L 3compartmentss NA 95% Human Human -DTXSID6041133 Css NA 7.171 mg/L PBTK NA 50% Human Human -DTXSID6041133 Css NA 18.96 mg/L PBTK NA 95% Human Human -DTXSID6041133 Clint NA 0.1652 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6041133 Vd NA 2.845 L/kg 1compartment NA NA Human Human +DTXSID6041133 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6041133 TK.Half.Life NA 8.761 hours 1compartment NA NA Human Human +DTXSID6041133 Css NA 0.2624 mg/L 3compartmentss NA 50% Human Human +DTXSID6041133 Css NA 1.661 mg/L 3compartmentss NA 95% Human Human +DTXSID6041133 Css NA 0.1918 mg/L PBTK NA 50% Human Human +DTXSID6041133 Css NA 1.157 mg/L PBTK NA 95% Human Human +DTXSID6041133 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6041133 Fup 0.29 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6041133 Vd NA 2.166 L/kg 1compartment NA NA Rat Human -DTXSID6041133 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID6041133 TK.Half.Life NA 28.98 hours 1compartment NA NA Rat Human -DTXSID6041133 Css NA 3.136 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041133 Css NA 7.234 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041133 Css NA 2.218 mg/L PBTK NA 50% Rat Human -DTXSID6041133 Css NA 4.507 mg/L PBTK NA 95% Rat Human -DTXSID6041347 Clint NA 167.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041347 Fup NA 0.03 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041347 Vd NA 2.443 L/kg 1compartment NA NA Human Human -DTXSID6041347 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041347 TK.Half.Life NA 4.83 hours 1compartment NA NA Human Human -DTXSID6041347 Css NA 0.1747 mg/L 3compartmentss NA 50% Human Human -DTXSID6041347 Css NA 1.314 mg/L 3compartmentss NA 95% Human Human -DTXSID6041347 Css NA 0.1154 mg/L PBTK NA 50% Human Human -DTXSID6041347 Css NA 0.8195 mg/L PBTK NA 95% Human Human -DTXSID6041347 Clint NA 167.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041347 Fup NA 0.03 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041347 Vd NA 1.825 L/kg 1compartment NA NA Rat Human -DTXSID6041347 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041347 TK.Half.Life NA 1.38 hours 1compartment NA NA Rat Human -DTXSID6041347 Css NA 0.099 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041347 Css NA 0.6099 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041347 Css NA 0.06222 mg/L PBTK NA 50% Rat Human -DTXSID6041347 Css NA 0.3633 mg/L PBTK NA 95% Rat Human -DTXSID6041349 Clint NA 186.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041349 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041349 Vd NA 1.956 L/kg 1compartment NA NA Human Human +DTXSID6041133 Vd NA 2.161 L/kg 1compartment NA NA Rat Human +DTXSID6041133 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6041133 TK.Half.Life NA 1.977 hours 1compartment NA NA Rat Human +DTXSID6041133 Css NA 0.0254 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041133 Css NA 0.1312 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041133 Css NA 0.01867 mg/L PBTK NA 50% Rat Human +DTXSID6041133 Css NA 0.08836 mg/L PBTK NA 95% Rat Human +DTXSID6041268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041268 Fup 0.0301 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041268 Vd NA 1.401 L/kg 1compartment NA NA Human Human +DTXSID6041268 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6041268 TK.Half.Life NA 9.41 hours 1compartment NA NA Human Human +DTXSID6041268 Css NA 1.002 mg/L 3compartmentss NA 50% Human Human +DTXSID6041268 Css NA 8.779 mg/L 3compartmentss NA 95% Human Human +DTXSID6041268 Css NA 0.6284 mg/L PBTK NA 50% Human Human +DTXSID6041268 Css NA 5.353 mg/L PBTK NA 95% Human Human +DTXSID6041268 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041268 Fup 0.0301 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041268 Vd NA 1.045 L/kg 1compartment NA NA Rat Human +DTXSID6041268 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6041268 TK.Half.Life NA 3.733 hours 1compartment NA NA Rat Human +DTXSID6041268 Css NA 0.131 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041268 Css NA 0.9268 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041268 Css NA 0.0797 mg/L PBTK NA 50% Rat Human +DTXSID6041268 Css NA 0.5423 mg/L PBTK NA 95% Rat Human +DTXSID6041347 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041347 Fup 0.0261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041347 Vd NA 2.241 L/kg 1compartment NA NA Human Human +DTXSID6041347 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6041347 TK.Half.Life NA 20.92 hours 1compartment NA NA Human Human +DTXSID6041347 Css NA 1.331 mg/L 3compartmentss NA 50% Human Human +DTXSID6041347 Css NA 10.45 mg/L 3compartmentss NA 95% Human Human +DTXSID6041347 Css NA 0.8687 mg/L PBTK NA 50% Human Human +DTXSID6041347 Css NA 6.476 mg/L PBTK NA 95% Human Human +DTXSID6041347 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041347 Fup 0.0261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041347 Vd NA 1.671 L/kg 1compartment NA NA Rat Human +DTXSID6041347 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6041347 TK.Half.Life NA 6.038 hours 1compartment NA NA Rat Human +DTXSID6041347 Css NA 0.1707 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041347 Css NA 1.068 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041347 Css NA 0.1091 mg/L PBTK NA 50% Rat Human +DTXSID6041347 Css NA 0.656 mg/L PBTK NA 95% Rat Human +DTXSID6041349 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041349 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041349 Vd NA 2.187 L/kg 1compartment NA NA Human Human DTXSID6041349 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041349 TK.Half.Life NA 2.34 hours 1compartment NA NA Human Human -DTXSID6041349 Css NA 0.05596 mg/L 3compartmentss NA 50% Human Human -DTXSID6041349 Css NA 0.4286 mg/L 3compartmentss NA 95% Human Human -DTXSID6041349 Css NA 0.03726 mg/L PBTK NA 50% Human Human -DTXSID6041349 Css NA 0.2746 mg/L PBTK NA 95% Human Human -DTXSID6041349 Clint NA 186.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041349 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041349 Vd NA 1.476 L/kg 1compartment NA NA Rat Human +DTXSID6041349 TK.Half.Life NA 7.366 hours 1compartment NA NA Human Human +DTXSID6041349 Css NA 0.3602 mg/L 3compartmentss NA 50% Human Human +DTXSID6041349 Css NA 2.498 mg/L 3compartmentss NA 95% Human Human +DTXSID6041349 Css NA 0.2472 mg/L PBTK NA 50% Human Human +DTXSID6041349 Css NA 1.645 mg/L PBTK NA 95% Human Human +DTXSID6041349 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041349 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041349 Vd NA 1.655 L/kg 1compartment NA NA Rat Human DTXSID6041349 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041349 TK.Half.Life NA 0.7804 hours 1compartment NA NA Rat Human -DTXSID6041349 Css NA 0.03174 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041349 Css NA 0.1972 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041349 Css NA 0.02006 mg/L PBTK NA 50% Rat Human -DTXSID6041349 Css NA 0.12 mg/L PBTK NA 95% Rat Human -DTXSID6041420 Clint NA 0.0116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041420 Fup NA 0.3943 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041420 Vd NA 0.5268 L/kg 1compartment NA NA Human Human +DTXSID6041349 TK.Half.Life NA 2.28 hours 1compartment NA NA Rat Human +DTXSID6041349 Css NA 0.04648 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041349 Css NA 0.255 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041349 Css NA 0.0312 mg/L PBTK NA 50% Rat Human +DTXSID6041349 Css NA 0.1657 mg/L PBTK NA 95% Rat Human +DTXSID6041397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041397 Fup 0.0456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041397 Vd NA 1.938 L/kg 1compartment NA NA Human Human +DTXSID6041397 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6041397 TK.Half.Life NA 10.98 hours 1compartment NA NA Human Human +DTXSID6041397 Css NA 0.7321 mg/L 3compartmentss NA 50% Human Human +DTXSID6041397 Css NA 4.919 mg/L 3compartmentss NA 95% Human Human +DTXSID6041397 Css NA 0.4784 mg/L PBTK NA 50% Human Human +DTXSID6041397 Css NA 3.08 mg/L PBTK NA 95% Human Human +DTXSID6041397 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041397 Fup 0.0456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041397 Vd NA 1.451 L/kg 1compartment NA NA Rat Human +DTXSID6041397 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6041397 TK.Half.Life NA 3.666 hours 1compartment NA NA Rat Human +DTXSID6041397 Css NA 0.0957 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041397 Css NA 0.5194 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041397 Css NA 0.0611 mg/L PBTK NA 50% Rat Human +DTXSID6041397 Css NA 0.3236 mg/L PBTK NA 95% Rat Human +DTXSID6041420 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041420 Fup 0.487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041420 Vd NA 0.5934 L/kg 1compartment NA NA Human Human DTXSID6041420 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041420 TK.Half.Life NA 8.476 hours 1compartment NA NA Human Human -DTXSID6041420 Css NA 1.782 mg/L 3compartmentss NA 50% Human Human -DTXSID6041420 Css NA 7.983 mg/L 3compartmentss NA 95% Human Human -DTXSID6041420 Css NA 1.324 mg/L PBTK NA 50% Human Human -DTXSID6041420 Css NA 5.063 mg/L PBTK NA 95% Human Human -DTXSID6041420 Clint NA 0.0116 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041420 Fup NA 0.3943 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041420 Vd NA 0.5367 L/kg 1compartment NA NA Rat Human +DTXSID6041420 TK.Half.Life NA 0.594 hours 1compartment NA NA Human Human +DTXSID6041420 Css NA 0.03079 mg/L 3compartmentss NA 50% Human Human +DTXSID6041420 Css NA 0.3034 mg/L 3compartmentss NA 95% Human Human +DTXSID6041420 Css NA 0.0235 mg/L PBTK NA 50% Human Human +DTXSID6041420 Css NA 0.2087 mg/L PBTK NA 95% Human Human +DTXSID6041420 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041420 Fup 0.487 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041420 Vd NA 0.6051 L/kg 1compartment NA NA Rat Human DTXSID6041420 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041420 TK.Half.Life NA 2.971 hours 1compartment NA NA Rat Human -DTXSID6041420 Css NA 0.4982 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041420 Css NA 1.879 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041420 Css NA 0.3527 mg/L PBTK NA 50% Rat Human -DTXSID6041420 Css NA 1.115 mg/L PBTK NA 95% Rat Human -DTXSID6041422 Clint NA 13.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041422 Fup NA 0.102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041422 Vd NA 1.211 L/kg 1compartment NA NA Human Human -DTXSID6041422 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041422 TK.Half.Life NA 3.914 hours 1compartment NA NA Human Human -DTXSID6041422 Css NA 0.3814 mg/L 3compartmentss NA 50% Human Human -DTXSID6041422 Css NA 3.087 mg/L 3compartmentss NA 95% Human Human -DTXSID6041422 Css NA 0.269 mg/L PBTK NA 50% Human Human -DTXSID6041422 Css NA 1.931 mg/L PBTK NA 95% Human Human -DTXSID6041422 Clint NA 13.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041422 Fup NA 0.102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041422 Vd NA 1.201 L/kg 1compartment NA NA Rat Human -DTXSID6041422 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041422 TK.Half.Life NA 2.383 hours 1compartment NA NA Rat Human -DTXSID6041422 Css NA 0.206 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041422 Css NA 1.303 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041422 Css NA 0.1379 mg/L PBTK NA 50% Rat Human -DTXSID6041422 Css NA 0.7756 mg/L PBTK NA 95% Rat Human -DTXSID6041472 Clint NA 12.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041472 Fup NA 0.5283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041472 Vd NA 1.546 L/kg 1compartment NA NA Human Human +DTXSID6041420 TK.Half.Life NA 0.3059 hours 1compartment NA NA Rat Human +DTXSID6041420 Css NA 0.001089 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041420 Css NA 0.01206 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041420 Css NA 0.0008282 mg/L PBTK NA 50% Rat Human +DTXSID6041420 Css NA 0.007947 mg/L PBTK NA 95% Rat Human +DTXSID6041422 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041422 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041422 Vd NA 1.94 L/kg 1compartment NA NA Human Human +DTXSID6041422 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID6041422 TK.Half.Life NA 51.61 hours 1compartment NA NA Human Human +DTXSID6041422 Css NA 2.686 mg/L 3compartmentss NA 50% Human Human +DTXSID6041422 Css NA 9.896 mg/L 3compartmentss NA 95% Human Human +DTXSID6041422 Css NA 2.144 mg/L PBTK NA 50% Human Human +DTXSID6041422 Css NA 6.748 mg/L PBTK NA 95% Human Human +DTXSID6041422 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041422 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041422 Vd NA 1.551 L/kg 1compartment NA NA Rat Human +DTXSID6041422 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6041422 TK.Half.Life NA 10.21 hours 1compartment NA NA Rat Human +DTXSID6041422 Css NA 0.1693 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041422 Css NA 0.5281 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041422 Css NA 0.1347 mg/L PBTK NA 50% Rat Human +DTXSID6041422 Css NA 0.3443 mg/L PBTK NA 95% Rat Human +DTXSID6041472 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041472 Fup 0.484 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041472 Vd NA 1.646 L/kg 1compartment NA NA Human Human DTXSID6041472 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041472 TK.Half.Life NA 1.938 hours 1compartment NA NA Human Human -DTXSID6041472 Css NA 0.07437 mg/L 3compartmentss NA 50% Human Human -DTXSID6041472 Css NA 0.6211 mg/L 3compartmentss NA 95% Human Human -DTXSID6041472 Css NA 0.06261 mg/L PBTK NA 50% Human Human -DTXSID6041472 Css NA 0.4407 mg/L PBTK NA 95% Human Human -DTXSID6041472 Clint NA 12.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041472 Fup NA 0.5283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041472 Vd NA 1.307 L/kg 1compartment NA NA Rat Human +DTXSID6041472 TK.Half.Life NA 1.735 hours 1compartment NA NA Human Human +DTXSID6041472 Css NA 0.04534 mg/L 3compartmentss NA 50% Human Human +DTXSID6041472 Css NA 0.3688 mg/L 3compartmentss NA 95% Human Human +DTXSID6041472 Css NA 0.03746 mg/L PBTK NA 50% Human Human +DTXSID6041472 Css NA 0.2725 mg/L PBTK NA 95% Human Human +DTXSID6041472 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041472 Fup 0.484 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041472 Vd NA 1.366 L/kg 1compartment NA NA Rat Human DTXSID6041472 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041472 TK.Half.Life NA 0.8046 hours 1compartment NA NA Rat Human -DTXSID6041472 Css NA 0.03914 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041472 Css NA 0.2526 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041472 Css NA 0.03191 mg/L PBTK NA 50% Rat Human -DTXSID6041472 Css NA 0.1694 mg/L PBTK NA 95% Rat Human -DTXSID6041503 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041503 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041503 Vd NA 1.174 L/kg 1compartment NA NA Human Human -DTXSID6041503 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID6041503 TK.Half.Life NA 2744 hours 1compartment NA NA Human Human -DTXSID6041503 Css NA 385.5 mg/L 3compartmentss NA 50% Human Human -DTXSID6041503 Css NA 1664 mg/L 3compartmentss NA 95% Human Human -DTXSID6041503 Css NA 233.2 mg/L PBTK NA 50% Human Human -DTXSID6041503 Css NA 976.4 mg/L PBTK NA 95% Human Human -DTXSID6041503 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041503 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041503 Vd NA 0.8588 L/kg 1compartment NA NA Rat Human -DTXSID6041503 Days.Css NA 179 Days PBTK NA NA Rat Human -DTXSID6041503 TK.Half.Life NA 575.2 hours 1compartment NA NA Rat Human -DTXSID6041503 Css NA 108.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041503 Css NA 396.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041503 Css NA 61.22 mg/L PBTK NA 50% Rat Human -DTXSID6041503 Css NA 217 mg/L PBTK NA 95% Rat Human -DTXSID6041507 Clint NA 58.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041507 Fup NA 0.1658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041507 Vd NA 2.111 L/kg 1compartment NA NA Human Human -DTXSID6041507 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041507 TK.Half.Life NA 2.963 hours 1compartment NA NA Human Human -DTXSID6041507 Css NA 0.07914 mg/L 3compartmentss NA 50% Human Human -DTXSID6041507 Css NA 0.5178 mg/L 3compartmentss NA 95% Human Human -DTXSID6041507 Css NA 0.05681 mg/L PBTK NA 50% Human Human -DTXSID6041507 Css NA 0.3521 mg/L PBTK NA 95% Human Human -DTXSID6041507 Clint NA 58.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041507 Fup NA 0.1658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041507 Vd NA 1.615 L/kg 1compartment NA NA Rat Human -DTXSID6041507 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041507 TK.Half.Life NA 0.9776 hours 1compartment NA NA Rat Human -DTXSID6041507 Css NA 0.04418 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041507 Css NA 0.2335 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041507 Css NA 0.03014 mg/L PBTK NA 50% Rat Human -DTXSID6041507 Css NA 0.1546 mg/L PBTK NA 95% Rat Human -DTXSID6041551 Clint NA 26.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041551 Fup NA 0.0568 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041551 Vd NA 2.801 L/kg 1compartment NA NA Human Human -DTXSID6041551 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6041551 TK.Half.Life NA 21.03 hours 1compartment NA NA Human Human -DTXSID6041551 Css NA 0.9162 mg/L 3compartmentss NA 50% Human Human -DTXSID6041551 Css NA 5.793 mg/L 3compartmentss NA 95% Human Human -DTXSID6041551 Css NA 0.6285 mg/L PBTK NA 50% Human Human -DTXSID6041551 Css NA 3.846 mg/L PBTK NA 95% Human Human -DTXSID6041551 Clint NA 26.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041551 Fup NA 0.0568 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041551 Vd NA 2.101 L/kg 1compartment NA NA Rat Human +DTXSID6041472 TK.Half.Life NA 0.6816 hours 1compartment NA NA Rat Human +DTXSID6041472 Css NA 0.005604 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041472 Css NA 0.03783 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041472 Css NA 0.004689 mg/L PBTK NA 50% Rat Human +DTXSID6041472 Css NA 0.02705 mg/L PBTK NA 95% Rat Human +DTXSID6041503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041503 Fup 0.0212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041503 Vd NA 2.14 L/kg 1compartment NA NA Human Human +DTXSID6041503 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6041503 TK.Half.Life NA 21.96 hours 1compartment NA NA Human Human +DTXSID6041503 Css NA 1.493 mg/L 3compartmentss NA 50% Human Human +DTXSID6041503 Css NA 11.77 mg/L 3compartmentss NA 95% Human Human +DTXSID6041503 Css NA 0.969 mg/L PBTK NA 50% Human Human +DTXSID6041503 Css NA 7.248 mg/L PBTK NA 95% Human Human +DTXSID6041503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041503 Fup 0.0212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041503 Vd NA 1.593 L/kg 1compartment NA NA Rat Human +DTXSID6041503 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6041503 TK.Half.Life NA 6.633 hours 1compartment NA NA Rat Human +DTXSID6041503 Css NA 0.1933 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041503 Css NA 1.217 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041503 Css NA 0.1225 mg/L PBTK NA 50% Rat Human +DTXSID6041503 Css NA 0.7353 mg/L PBTK NA 95% Rat Human +DTXSID6041551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041551 Fup 0.0244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041551 Vd NA 2.462 L/kg 1compartment NA NA Human Human +DTXSID6041551 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6041551 TK.Half.Life NA 26.74 hours 1compartment NA NA Human Human +DTXSID6041551 Css NA 1.486 mg/L 3compartmentss NA 50% Human Human +DTXSID6041551 Css NA 11.19 mg/L 3compartmentss NA 95% Human Human +DTXSID6041551 Css NA 0.9872 mg/L PBTK NA 50% Human Human +DTXSID6041551 Css NA 7.159 mg/L PBTK NA 95% Human Human +DTXSID6041551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041551 Fup 0.0244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041551 Vd NA 1.838 L/kg 1compartment NA NA Rat Human DTXSID6041551 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6041551 TK.Half.Life NA 4.324 hours 1compartment NA NA Rat Human -DTXSID6041551 Css NA 0.5097 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041551 Css NA 2.659 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041551 Css NA 0.3336 mg/L PBTK NA 50% Rat Human -DTXSID6041551 Css NA 1.694 mg/L PBTK NA 95% Rat Human -DTXSID6041557 Clint NA 12.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041557 Fup NA 0.2141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041557 Vd NA 2.667 L/kg 1compartment NA NA Human Human -DTXSID6041557 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041557 TK.Half.Life NA 12.55 hours 1compartment NA NA Human Human -DTXSID6041557 Css NA 0.471 mg/L 3compartmentss NA 50% Human Human -DTXSID6041557 Css NA 2.915 mg/L 3compartmentss NA 95% Human Human -DTXSID6041557 Css NA 0.3431 mg/L PBTK NA 50% Human Human -DTXSID6041557 Css NA 1.998 mg/L PBTK NA 95% Human Human -DTXSID6041557 Clint NA 12.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041557 Fup NA 0.2141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041557 Vd NA 2.026 L/kg 1compartment NA NA Rat Human -DTXSID6041557 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041557 TK.Half.Life NA 2.993 hours 1compartment NA NA Rat Human -DTXSID6041557 Css NA 0.2583 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041557 Css NA 1.124 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041557 Css NA 0.18 mg/L PBTK NA 50% Rat Human -DTXSID6041557 Css NA 0.7449 mg/L PBTK NA 95% Rat Human -DTXSID6041638 Clint NA 5.039 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041638 Fup NA 0.3547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041638 Vd NA 1.276 L/kg 1compartment NA NA Human Human +DTXSID6041551 TK.Half.Life NA 6.796 hours 1compartment NA NA Rat Human +DTXSID6041551 Css NA 0.1938 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041551 Css NA 1.179 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041551 Css NA 0.1258 mg/L PBTK NA 50% Rat Human +DTXSID6041551 Css NA 0.7373 mg/L PBTK NA 95% Rat Human +DTXSID6041636 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041636 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041636 Vd NA 1.747 L/kg 1compartment NA NA Human Human +DTXSID6041636 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6041636 TK.Half.Life NA 3.142 hours 1compartment NA NA Human Human +DTXSID6041636 Css NA 0.1244 mg/L 3compartmentss NA 50% Human Human +DTXSID6041636 Css NA 0.8488 mg/L 3compartmentss NA 95% Human Human +DTXSID6041636 Css NA 0.09054 mg/L PBTK NA 50% Human Human +DTXSID6041636 Css NA 0.5767 mg/L PBTK NA 95% Human Human +DTXSID6041636 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041636 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041636 Vd NA 1.365 L/kg 1compartment NA NA Rat Human +DTXSID6041636 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6041636 TK.Half.Life NA 1.158 hours 1compartment NA NA Rat Human +DTXSID6041636 Css NA 0.01562 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041636 Css NA 0.08084 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041636 Css NA 0.01133 mg/L PBTK NA 50% Rat Human +DTXSID6041636 Css NA 0.05514 mg/L PBTK NA 95% Rat Human +DTXSID6041638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041638 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041638 Vd NA 1.241 L/kg 1compartment NA NA Human Human DTXSID6041638 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041638 TK.Half.Life NA 3.461 hours 1compartment NA NA Human Human -DTXSID6041638 Css NA 0.2409 mg/L 3compartmentss NA 50% Human Human -DTXSID6041638 Css NA 1.401 mg/L 3compartmentss NA 95% Human Human -DTXSID6041638 Css NA 0.1873 mg/L PBTK NA 50% Human Human -DTXSID6041638 Css NA 0.9693 mg/L PBTK NA 95% Human Human -DTXSID6041638 Clint NA 5.039 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041638 Fup NA 0.3547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041638 Vd NA 1.081 L/kg 1compartment NA NA Rat Human +DTXSID6041638 TK.Half.Life NA 1.536 hours 1compartment NA NA Human Human +DTXSID6041638 Css NA 0.06102 mg/L 3compartmentss NA 50% Human Human +DTXSID6041638 Css NA 0.4598 mg/L 3compartmentss NA 95% Human Human +DTXSID6041638 Css NA 0.04684 mg/L PBTK NA 50% Human Human +DTXSID6041638 Css NA 0.3205 mg/L PBTK NA 95% Human Human +DTXSID6041638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041638 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041638 Vd NA 1.051 L/kg 1compartment NA NA Rat Human DTXSID6041638 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041638 TK.Half.Life NA 1.538 hours 1compartment NA NA Rat Human -DTXSID6041638 Css NA 0.1204 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041638 Css NA 0.5311 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041638 Css NA 0.09038 mg/L PBTK NA 50% Rat Human -DTXSID6041638 Css NA 0.3428 mg/L PBTK NA 95% Rat Human +DTXSID6041638 TK.Half.Life NA 0.6576 hours 1compartment NA NA Rat Human +DTXSID6041638 Css NA 0.007573 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041638 Css NA 0.0456 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041638 Css NA 0.005812 mg/L PBTK NA 50% Rat Human +DTXSID6041638 Css NA 0.03147 mg/L PBTK NA 95% Rat Human DTXSID6041682 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6041682 Fup NA 0.0025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041682 Vd NA 0.3709 L/kg 1compartment NA NA Human Human -DTXSID6041682 Days.Css NA 262 Days PBTK NA NA Human Human -DTXSID6041682 TK.Half.Life NA 980.5 hours 1compartment NA NA Human Human -DTXSID6041682 Css NA 457.6 mg/L 3compartmentss NA 50% Human Human -DTXSID6041682 Css NA 2363 mg/L 3compartmentss NA 95% Human Human -DTXSID6041682 Css NA 267 mg/L PBTK NA 50% Human Human -DTXSID6041682 Css NA 1356 mg/L PBTK NA 95% Human Human +DTXSID6041682 Fup 0.0128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041682 Vd NA 0.2245 L/kg 1compartment NA NA Human Human +DTXSID6041682 Days.Css NA 24 Days PBTK NA NA Human Human +DTXSID6041682 TK.Half.Life NA 113.6 hours 1compartment NA NA Human Human +DTXSID6041682 Css NA 73.2 mg/L 3compartmentss NA 50% Human Human +DTXSID6041682 Css NA 461.2 mg/L 3compartmentss NA 95% Human Human +DTXSID6041682 Css NA 43.35 mg/L PBTK NA 50% Human Human +DTXSID6041682 Css NA 267.3 mg/L PBTK NA 95% Human Human DTXSID6041682 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6041682 Fup NA 0.0025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041682 Vd NA 0.2894 L/kg 1compartment NA NA Rat Human -DTXSID6041682 Days.Css NA 64 Days PBTK NA NA Rat Human -DTXSID6041682 TK.Half.Life NA 256.5 hours 1compartment NA NA Rat Human -DTXSID6041682 Css NA 129.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041682 Css NA 572.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041682 Css NA 70.87 mg/L PBTK NA 50% Rat Human -DTXSID6041682 Css NA 309.8 mg/L PBTK NA 95% Rat Human -DTXSID6041684 Clint NA 47.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041684 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041684 Vd NA 3.915 L/kg 1compartment NA NA Human Human -DTXSID6041684 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID6041684 TK.Half.Life NA 55.76 hours 1compartment NA NA Human Human -DTXSID6041684 Css NA 1.515 mg/L 3compartmentss NA 50% Human Human -DTXSID6041684 Css NA 8.431 mg/L 3compartmentss NA 95% Human Human -DTXSID6041684 Css NA 1.125 mg/L PBTK NA 50% Human Human -DTXSID6041684 Css NA 6.118 mg/L PBTK NA 95% Human Human -DTXSID6041684 Clint NA 47.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041684 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041684 Vd NA 2.959 L/kg 1compartment NA NA Rat Human -DTXSID6041684 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID6041684 TK.Half.Life NA 8.015 hours 1compartment NA NA Rat Human -DTXSID6041684 Css NA 0.8504 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041684 Css NA 3.629 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041684 Css NA 0.6066 mg/L PBTK NA 50% Rat Human -DTXSID6041684 Css NA 2.57 mg/L PBTK NA 95% Rat Human -DTXSID6041688 Clint NA 13.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041688 Fup NA 0.0618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041688 Vd NA 1.179 L/kg 1compartment NA NA Human Human +DTXSID6041682 Fup 0.0128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041682 Vd NA 0.2144 L/kg 1compartment NA NA Rat Human +DTXSID6041682 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID6041682 TK.Half.Life NA 36.93 hours 1compartment NA NA Rat Human +DTXSID6041682 Css NA 1.39 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041682 Css NA 11.72 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041682 Css NA 0.776 mg/L PBTK NA 50% Rat Human +DTXSID6041682 Css NA 6.503 mg/L PBTK NA 95% Rat Human +DTXSID6041684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041684 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041684 Vd NA 3.924 L/kg 1compartment NA NA Human Human +DTXSID6041684 Days.Css NA 20 Days PBTK NA NA Human Human +DTXSID6041684 TK.Half.Life NA 118.8 hours 1compartment NA NA Human Human +DTXSID6041684 Css NA 3.192 mg/L 3compartmentss NA 50% Human Human +DTXSID6041684 Css NA 19.69 mg/L 3compartmentss NA 95% Human Human +DTXSID6041684 Css NA 2.374 mg/L PBTK NA 50% Human Human +DTXSID6041684 Css NA 14.42 mg/L PBTK NA 95% Human Human +DTXSID6041684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041684 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041684 Vd NA 2.968 L/kg 1compartment NA NA Rat Human +DTXSID6041684 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID6041684 TK.Half.Life NA 16.2 hours 1compartment NA NA Rat Human +DTXSID6041684 Css NA 0.4186 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041684 Css NA 2.114 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041684 Css NA 0.309 mg/L PBTK NA 50% Rat Human +DTXSID6041684 Css NA 1.583 mg/L PBTK NA 95% Rat Human +DTXSID6041688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041688 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041688 Vd NA 1.69 L/kg 1compartment NA NA Human Human DTXSID6041688 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041688 TK.Half.Life NA 6.484 hours 1compartment NA NA Human Human -DTXSID6041688 Css NA 0.8156 mg/L 3compartmentss NA 50% Human Human -DTXSID6041688 Css NA 5.958 mg/L 3compartmentss NA 95% Human Human -DTXSID6041688 Css NA 0.5198 mg/L PBTK NA 50% Human Human -DTXSID6041688 Css NA 3.623 mg/L PBTK NA 95% Human Human -DTXSID6041688 Clint NA 13.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041688 Fup NA 0.0618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041688 Vd NA 0.9037 L/kg 1compartment NA NA Rat Human +DTXSID6041688 TK.Half.Life NA 4.082 hours 1compartment NA NA Human Human +DTXSID6041688 Css NA 0.2315 mg/L 3compartmentss NA 50% Human Human +DTXSID6041688 Css NA 1.804 mg/L 3compartmentss NA 95% Human Human +DTXSID6041688 Css NA 0.1591 mg/L PBTK NA 50% Human Human +DTXSID6041688 Css NA 1.172 mg/L PBTK NA 95% Human Human +DTXSID6041688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041688 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041688 Vd NA 1.306 L/kg 1compartment NA NA Rat Human DTXSID6041688 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041688 TK.Half.Life NA 2.763 hours 1compartment NA NA Rat Human -DTXSID6041688 Css NA 0.4548 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041688 Css NA 2.559 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041688 Css NA 0.2711 mg/L PBTK NA 50% Rat Human -DTXSID6041688 Css NA 1.483 mg/L PBTK NA 95% Rat Human -DTXSID6041715 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041715 Fup NA 0.0282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041715 Vd NA 0.2171 L/kg 1compartment NA NA Human Human -DTXSID6041715 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID6041715 TK.Half.Life NA 49.8 hours 1compartment NA NA Human Human -DTXSID6041715 Css NA 39.3 mg/L 3compartmentss NA 50% Human Human -DTXSID6041715 Css NA 240.3 mg/L 3compartmentss NA 95% Human Human -DTXSID6041715 Css NA 23.37 mg/L PBTK NA 50% Human Human -DTXSID6041715 Css NA 138.7 mg/L PBTK NA 95% Human Human -DTXSID6041715 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041715 Fup NA 0.0282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041715 Vd NA 0.2148 L/kg 1compartment NA NA Rat Human -DTXSID6041715 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6041715 TK.Half.Life NA 16.79 hours 1compartment NA NA Rat Human -DTXSID6041715 Css NA 11.35 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041715 Css NA 58.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041715 Css NA 6.268 mg/L PBTK NA 50% Rat Human -DTXSID6041715 Css NA 31.73 mg/L PBTK NA 95% Rat Human -DTXSID6041719 Clint NA 1.594 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041719 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041719 Vd NA 0.1885 L/kg 1compartment NA NA Human Human -DTXSID6041719 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6041719 TK.Half.Life NA 13.48 hours 1compartment NA NA Human Human -DTXSID6041719 Css NA 12.81 mg/L 3compartmentss NA 50% Human Human -DTXSID6041719 Css NA 86.35 mg/L 3compartmentss NA 95% Human Human -DTXSID6041719 Css NA 7.539 mg/L PBTK NA 50% Human Human -DTXSID6041719 Css NA 50.34 mg/L PBTK NA 95% Human Human -DTXSID6041719 Clint NA 1.594 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041719 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041719 Vd NA 0.1871 L/kg 1compartment NA NA Rat Human +DTXSID6041688 TK.Half.Life NA 1.526 hours 1compartment NA NA Rat Human +DTXSID6041688 Css NA 0.02978 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041688 Css NA 0.1705 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041688 Css NA 0.02 mg/L PBTK NA 50% Rat Human +DTXSID6041688 Css NA 0.1067 mg/L PBTK NA 95% Rat Human +DTXSID6041715 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041715 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041715 Vd NA 0.2288 L/kg 1compartment NA NA Human Human +DTXSID6041715 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6041715 TK.Half.Life NA 20.59 hours 1compartment NA NA Human Human +DTXSID6041715 Css NA 7.902 mg/L 3compartmentss NA 50% Human Human +DTXSID6041715 Css NA 37.53 mg/L 3compartmentss NA 95% Human Human +DTXSID6041715 Css NA 4.73 mg/L PBTK NA 50% Human Human +DTXSID6041715 Css NA 21.69 mg/L PBTK NA 95% Human Human +DTXSID6041715 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041715 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041715 Vd NA 0.2329 L/kg 1compartment NA NA Rat Human +DTXSID6041715 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6041715 TK.Half.Life NA 7.143 hours 1compartment NA NA Rat Human +DTXSID6041715 Css NA 0.04344 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041715 Css NA 0.1996 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041715 Css NA 0.02447 mg/L PBTK NA 50% Rat Human +DTXSID6041715 Css NA 0.1097 mg/L PBTK NA 95% Rat Human +DTXSID6041719 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041719 Fup 0.0607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041719 Vd NA 0.2029 L/kg 1compartment NA NA Human Human +DTXSID6041719 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6041719 TK.Half.Life NA 1.797 hours 1compartment NA NA Human Human +DTXSID6041719 Css NA 0.804 mg/L 3compartmentss NA 50% Human Human +DTXSID6041719 Css NA 5.761 mg/L 3compartmentss NA 95% Human Human +DTXSID6041719 Css NA 0.4765 mg/L PBTK NA 50% Human Human +DTXSID6041719 Css NA 3.308 mg/L PBTK NA 95% Human Human +DTXSID6041719 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041719 Fup 0.0607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041719 Vd NA 0.2051 L/kg 1compartment NA NA Rat Human DTXSID6041719 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041719 TK.Half.Life NA 7.27 hours 1compartment NA NA Rat Human -DTXSID6041719 Css NA 5.813 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041719 Css NA 33.95 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041719 Css NA 3.192 mg/L PBTK NA 50% Rat Human -DTXSID6041719 Css NA 18.37 mg/L PBTK NA 95% Rat Human -DTXSID6041761 Clint NA 213.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041761 Fup NA 0.2634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041761 Vd NA 354.8 L/kg 1compartment NA NA Human Human -DTXSID6041761 Days.Css NA 253 Days PBTK NA NA Human Human -DTXSID6041761 TK.Half.Life NA 1054 hours 1compartment NA NA Human Human -DTXSID6041761 Css NA 0.004741 mg/L 3compartmentss NA 50% Human Human -DTXSID6041761 Css NA 0.03054 mg/L 3compartmentss NA 95% Human Human -DTXSID6041761 Css NA 0.2448 mg/L PBTK NA 50% Human Human -DTXSID6041761 Css NA 1.393 mg/L PBTK NA 95% Human Human -DTXSID6041761 Clint NA 213.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041761 Fup NA 0.2634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041761 Vd NA 318 L/kg 1compartment NA NA Rat Human -DTXSID6041761 Days.Css NA 173 Days PBTK NA NA Rat Human -DTXSID6041761 TK.Half.Life NA 159.2 hours 1compartment NA NA Rat Human -DTXSID6041761 Css NA 0.002422 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041761 Css NA 0.01054 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041761 Css NA 0.1318 mg/L PBTK NA 50% Rat Human -DTXSID6041761 Css NA 0.6097 mg/L PBTK NA 95% Rat Human +DTXSID6041719 TK.Half.Life NA 1.135 hours 1compartment NA NA Rat Human +DTXSID6041719 Css NA 0.00829 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041719 Css NA 0.05052 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041719 Css NA 0.00463 mg/L PBTK NA 50% Rat Human +DTXSID6041719 Css NA 0.02776 mg/L PBTK NA 95% Rat Human DTXSID6041844 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6041844 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041844 Vd NA 0.6911 L/kg 1compartment NA NA Human Human +DTXSID6041844 Vd NA 0.6879 L/kg 1compartment NA NA Human Human DTXSID6041844 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041844 TK.Half.Life NA 4.472 hours 1compartment NA NA Human Human -DTXSID6041844 Css NA 0.8473 mg/L 3compartmentss NA 50% Human Human -DTXSID6041844 Css NA 5.576 mg/L 3compartmentss NA 95% Human Human -DTXSID6041844 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID6041844 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID6041844 TK.Half.Life NA 4.452 hours 1compartment NA NA Human Human +DTXSID6041844 Css NA 0.7148 mg/L 3compartmentss NA 50% Human Human +DTXSID6041844 Css NA 5.072 mg/L 3compartmentss NA 95% Human Human +DTXSID6041844 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID6041844 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID6041844 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6041844 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041844 Vd NA 0.742 L/kg 1compartment NA NA Rat Human +DTXSID6041844 Vd NA 0.7394 L/kg 1compartment NA NA Rat Human DTXSID6041844 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041844 TK.Half.Life NA 1.636 hours 1compartment NA NA Rat Human -DTXSID6041844 Css NA 0.2129 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041844 Css NA 1.339 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041844 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID6041844 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID6041892 Clint NA 4.215 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041892 Fup NA 0.1281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041892 Vd NA 1.26 L/kg 1compartment NA NA Human Human +DTXSID6041844 TK.Half.Life NA 1.63 hours 1compartment NA NA Rat Human +DTXSID6041844 Css NA 0.01312 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041844 Css NA 0.1002 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041844 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID6041844 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID6041892 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041892 Fup 0.0702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041892 Vd NA 0.9286 L/kg 1compartment NA NA Human Human DTXSID6041892 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041892 TK.Half.Life NA 9.707 hours 1compartment NA NA Human Human -DTXSID6041892 Css NA 1.058 mg/L 3compartmentss NA 50% Human Human -DTXSID6041892 Css NA 6.71 mg/L 3compartmentss NA 95% Human Human -DTXSID6041892 Css NA 0.71 mg/L PBTK NA 50% Human Human -DTXSID6041892 Css NA 4.148 mg/L PBTK NA 95% Human Human +DTXSID6041892 TK.Half.Life NA 3.117 hours 1compartment NA NA Human Human +DTXSID6041892 Css NA 0.4122 mg/L 3compartmentss NA 50% Human Human +DTXSID6041892 Css NA 2.942 mg/L 3compartmentss NA 95% Human Human +DTXSID6041892 Css NA 0.2592 mg/L PBTK NA 50% Human Human +DTXSID6041892 Css NA 1.825 mg/L PBTK NA 95% Human Human DTXSID6041892 Clint 6.1 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID6041892 Fup 0.0758 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID6041892 Vd NA 0.7523 L/kg 1compartment NA NA Rat Rat DTXSID6041892 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID6041892 TK.Half.Life NA 3.685 hours 1compartment NA NA Rat Rat -DTXSID6041892 Css NA 0.7011 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6041892 Css NA 3.394 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6041892 Css NA 0.4172 mg/L PBTK NA 50% Rat Rat -DTXSID6041892 Css NA 1.918 mg/L PBTK NA 95% Rat Rat -DTXSID6041925 Clint NA 14.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041925 Fup NA 0.5341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041925 Vd NA 1.566 L/kg 1compartment NA NA Human Human +DTXSID6041892 Css NA 0.1568 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6041892 Css NA 0.7532 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6041892 Css NA 0.09726 mg/L PBTK NA 50% Rat Rat +DTXSID6041892 Css NA 0.4428 mg/L PBTK NA 95% Rat Rat +DTXSID6041925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041925 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041925 Vd NA 1.598 L/kg 1compartment NA NA Human Human DTXSID6041925 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041925 TK.Half.Life NA 1.802 hours 1compartment NA NA Human Human -DTXSID6041925 Css NA 0.06292 mg/L 3compartmentss NA 50% Human Human -DTXSID6041925 Css NA 0.5228 mg/L 3compartmentss NA 95% Human Human -DTXSID6041925 Css NA 0.05297 mg/L PBTK NA 50% Human Human -DTXSID6041925 Css NA 0.3686 mg/L PBTK NA 95% Human Human -DTXSID6041925 Clint NA 14.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041925 Fup NA 0.5341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041925 Vd NA 1.322 L/kg 1compartment NA NA Rat Human +DTXSID6041925 TK.Half.Life NA 1.938 hours 1compartment NA NA Human Human +DTXSID6041925 Css NA 0.05986 mg/L 3compartmentss NA 50% Human Human +DTXSID6041925 Css NA 0.4563 mg/L 3compartmentss NA 95% Human Human +DTXSID6041925 Css NA 0.04708 mg/L PBTK NA 50% Human Human +DTXSID6041925 Css NA 0.3266 mg/L PBTK NA 95% Human Human +DTXSID6041925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041925 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041925 Vd NA 1.305 L/kg 1compartment NA NA Rat Human DTXSID6041925 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041925 TK.Half.Life NA 0.739 hours 1compartment NA NA Rat Human -DTXSID6041925 Css NA 0.0326 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041925 Css NA 0.2215 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041925 Css NA 0.0267 mg/L PBTK NA 50% Rat Human -DTXSID6041925 Css NA 0.1518 mg/L PBTK NA 95% Rat Human -DTXSID6041927 Clint NA 5.812 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041927 Fup NA 0.1434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041927 Vd NA 1.124 L/kg 1compartment NA NA Human Human +DTXSID6041925 TK.Half.Life NA 0.7589 hours 1compartment NA NA Rat Human +DTXSID6041925 Css NA 0.007386 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041925 Css NA 0.04165 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041925 Css NA 0.005884 mg/L PBTK NA 50% Rat Human +DTXSID6041925 Css NA 0.02915 mg/L PBTK NA 95% Rat Human +DTXSID6041927 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041927 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041927 Vd NA 1.519 L/kg 1compartment NA NA Human Human DTXSID6041927 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6041927 TK.Half.Life NA 5.904 hours 1compartment NA NA Human Human -DTXSID6041927 Css NA 0.6684 mg/L 3compartmentss NA 50% Human Human -DTXSID6041927 Css NA 4.477 mg/L 3compartmentss NA 95% Human Human -DTXSID6041927 Css NA 0.451 mg/L PBTK NA 50% Human Human -DTXSID6041927 Css NA 2.761 mg/L PBTK NA 95% Human Human -DTXSID6041927 Clint NA 5.812 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041927 Fup NA 0.1434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041927 Vd NA 0.8964 L/kg 1compartment NA NA Rat Human +DTXSID6041927 TK.Half.Life NA 2.287 hours 1compartment NA NA Human Human +DTXSID6041927 Css NA 0.09139 mg/L 3compartmentss NA 50% Human Human +DTXSID6041927 Css NA 0.6394 mg/L 3compartmentss NA 95% Human Human +DTXSID6041927 Css NA 0.06796 mg/L PBTK NA 50% Human Human +DTXSID6041927 Css NA 0.437 mg/L PBTK NA 95% Human Human +DTXSID6041927 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041927 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041927 Vd NA 1.219 L/kg 1compartment NA NA Rat Human DTXSID6041927 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6041927 TK.Half.Life NA 2.565 hours 1compartment NA NA Rat Human -DTXSID6041927 Css NA 0.35 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041927 Css NA 1.731 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041927 Css NA 0.2232 mg/L PBTK NA 50% Rat Human -DTXSID6041927 Css NA 0.9967 mg/L PBTK NA 95% Rat Human -DTXSID6041977 Clint NA 12.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041977 Fup NA 0.0177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6041977 Vd NA 1.73 L/kg 1compartment NA NA Human Human -DTXSID6041977 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6041977 TK.Half.Life NA 30.51 hours 1compartment NA NA Human Human -DTXSID6041977 Css NA 2.881 mg/L 3compartmentss NA 50% Human Human -DTXSID6041977 Css NA 23.58 mg/L 3compartmentss NA 95% Human Human -DTXSID6041977 Css NA 1.822 mg/L PBTK NA 50% Human Human -DTXSID6041977 Css NA 14.2 mg/L PBTK NA 95% Human Human -DTXSID6041977 Clint NA 12.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041977 Fup NA 0.0177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6041977 Vd NA 1.283 L/kg 1compartment NA NA Rat Human -DTXSID6041977 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6041977 TK.Half.Life NA 10.8 hours 1compartment NA NA Rat Human -DTXSID6041977 Css NA 1.572 mg/L 3compartmentss NA 50% Rat Human -DTXSID6041977 Css NA 10.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID6041977 Css NA 0.9381 mg/L PBTK NA 50% Rat Human -DTXSID6041977 Css NA 5.854 mg/L PBTK NA 95% Rat Human -DTXSID6042072 Clint NA 92.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042072 Fup NA 0.1513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042072 Vd NA 0.6157 L/kg 1compartment NA NA Human Human +DTXSID6041927 TK.Half.Life NA 0.9023 hours 1compartment NA NA Rat Human +DTXSID6041927 Css NA 0.01144 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041927 Css NA 0.06243 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041927 Css NA 0.00846 mg/L PBTK NA 50% Rat Human +DTXSID6041927 Css NA 0.04294 mg/L PBTK NA 95% Rat Human +DTXSID6041973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041973 Fup 0.016 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041973 Vd NA 1.619 L/kg 1compartment NA NA Human Human +DTXSID6041973 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6041973 TK.Half.Life NA 17.77 hours 1compartment NA NA Human Human +DTXSID6041973 Css NA 1.695 mg/L 3compartmentss NA 50% Human Human +DTXSID6041973 Css NA 15.44 mg/L 3compartmentss NA 95% Human Human +DTXSID6041973 Css NA 1.066 mg/L PBTK NA 50% Human Human +DTXSID6041973 Css NA 9.218 mg/L PBTK NA 95% Human Human +DTXSID6041973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041973 Fup 0.016 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041973 Vd NA 1.199 L/kg 1compartment NA NA Rat Human +DTXSID6041973 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6041973 TK.Half.Life NA 6.583 hours 1compartment NA NA Rat Human +DTXSID6041973 Css NA 0.221 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041973 Css NA 1.584 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041973 Css NA 0.135 mg/L PBTK NA 50% Rat Human +DTXSID6041973 Css NA 0.9306 mg/L PBTK NA 95% Rat Human +DTXSID6041977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041977 Fup 0.0228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6041977 Vd NA 1.899 L/kg 1compartment NA NA Human Human +DTXSID6041977 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6041977 TK.Half.Life NA 17.27 hours 1compartment NA NA Human Human +DTXSID6041977 Css NA 1.369 mg/L 3compartmentss NA 50% Human Human +DTXSID6041977 Css NA 11.05 mg/L 3compartmentss NA 95% Human Human +DTXSID6041977 Css NA 0.8711 mg/L PBTK NA 50% Human Human +DTXSID6041977 Css NA 6.725 mg/L PBTK NA 95% Human Human +DTXSID6041977 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041977 Fup 0.0228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6041977 Vd NA 1.412 L/kg 1compartment NA NA Rat Human +DTXSID6041977 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6041977 TK.Half.Life NA 5.796 hours 1compartment NA NA Rat Human +DTXSID6041977 Css NA 0.1727 mg/L 3compartmentss NA 50% Rat Human +DTXSID6041977 Css NA 1.218 mg/L 3compartmentss NA 95% Rat Human +DTXSID6041977 Css NA 0.1082 mg/L PBTK NA 50% Rat Human +DTXSID6041977 Css NA 0.7201 mg/L PBTK NA 95% Rat Human +DTXSID6042072 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042072 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042072 Vd NA 0.8823 L/kg 1compartment NA NA Human Human DTXSID6042072 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042072 TK.Half.Life NA 0.689 hours 1compartment NA NA Human Human -DTXSID6042072 Css NA 0.04249 mg/L 3compartmentss NA 50% Human Human -DTXSID6042072 Css NA 0.3588 mg/L 3compartmentss NA 95% Human Human -DTXSID6042072 Css NA 0.02763 mg/L PBTK NA 50% Human Human -DTXSID6042072 Css NA 0.2211 mg/L PBTK NA 95% Human Human -DTXSID6042072 Clint NA 92.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042072 Fup NA 0.1513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042072 Vd NA 0.5185 L/kg 1compartment NA NA Rat Human +DTXSID6042072 TK.Half.Life NA 1.174 hours 1compartment NA NA Human Human +DTXSID6042072 Css NA 0.07107 mg/L 3compartmentss NA 50% Human Human +DTXSID6042072 Css NA 0.5203 mg/L 3compartmentss NA 95% Human Human +DTXSID6042072 Css NA 0.0515 mg/L PBTK NA 50% Human Human +DTXSID6042072 Css NA 0.3543 mg/L PBTK NA 95% Human Human +DTXSID6042072 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042072 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042072 Vd NA 0.7449 L/kg 1compartment NA NA Rat Human DTXSID6042072 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042072 TK.Half.Life NA 0.2852 hours 1compartment NA NA Rat Human -DTXSID6042072 Css NA 0.02398 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042072 Css NA 0.1582 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042072 Css NA 0.0147 mg/L PBTK NA 50% Rat Human -DTXSID6042072 Css NA 0.09368 mg/L PBTK NA 95% Rat Human -DTXSID6042074 Clint NA 15.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042074 Fup NA 0.1406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042074 Vd NA 2.689 L/kg 1compartment NA NA Human Human -DTXSID6042074 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6042074 TK.Half.Life NA 15.03 hours 1compartment NA NA Human Human -DTXSID6042074 Css NA 0.635 mg/L 3compartmentss NA 50% Human Human -DTXSID6042074 Css NA 3.984 mg/L 3compartmentss NA 95% Human Human -DTXSID6042074 Css NA 0.4468 mg/L PBTK NA 50% Human Human -DTXSID6042074 Css NA 2.664 mg/L PBTK NA 95% Human Human -DTXSID6042074 Clint NA 15.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042074 Fup NA 0.1406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042074 Vd NA 2.031 L/kg 1compartment NA NA Rat Human +DTXSID6042072 TK.Half.Life NA 0.5142 hours 1compartment NA NA Rat Human +DTXSID6042072 Css NA 0.008858 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042072 Css NA 0.04995 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042072 Css NA 0.006355 mg/L PBTK NA 50% Rat Human +DTXSID6042072 Css NA 0.03277 mg/L PBTK NA 95% Rat Human +DTXSID6042074 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042074 Fup 0.0546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042074 Vd NA 2.183 L/kg 1compartment NA NA Human Human +DTXSID6042074 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6042074 TK.Half.Life NA 12.07 hours 1compartment NA NA Human Human +DTXSID6042074 Css NA 0.7068 mg/L 3compartmentss NA 50% Human Human +DTXSID6042074 Css NA 4.828 mg/L 3compartmentss NA 95% Human Human +DTXSID6042074 Css NA 0.469 mg/L PBTK NA 50% Human Human +DTXSID6042074 Css NA 3.046 mg/L PBTK NA 95% Human Human +DTXSID6042074 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042074 Fup 0.0546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042074 Vd NA 1.637 L/kg 1compartment NA NA Rat Human DTXSID6042074 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042074 TK.Half.Life NA 3.461 hours 1compartment NA NA Rat Human -DTXSID6042074 Css NA 0.3514 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042074 Css NA 1.642 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042074 Css NA 0.235 mg/L PBTK NA 50% Rat Human -DTXSID6042074 Css NA 1.041 mg/L PBTK NA 95% Rat Human -DTXSID6042151 Clint NA 91.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042151 Fup NA 0.2191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042151 Vd NA 1.927 L/kg 1compartment NA NA Human Human +DTXSID6042074 TK.Half.Life NA 3.642 hours 1compartment NA NA Rat Human +DTXSID6042074 Css NA 0.09079 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042074 Css NA 0.5029 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042074 Css NA 0.05891 mg/L PBTK NA 50% Rat Human +DTXSID6042074 Css NA 0.3174 mg/L PBTK NA 95% Rat Human +DTXSID6042151 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042151 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042151 Vd NA 1.477 L/kg 1compartment NA NA Human Human DTXSID6042151 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042151 TK.Half.Life NA 1.979 hours 1compartment NA NA Human Human -DTXSID6042151 Css NA 0.03407 mg/L 3compartmentss NA 50% Human Human -DTXSID6042151 Css NA 0.2216 mg/L 3compartmentss NA 95% Human Human -DTXSID6042151 Css NA 0.02482 mg/L PBTK NA 50% Human Human -DTXSID6042151 Css NA 0.1543 mg/L PBTK NA 95% Human Human -DTXSID6042151 Clint NA 91.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042151 Fup NA 0.2191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042151 Vd NA 1.495 L/kg 1compartment NA NA Rat Human +DTXSID6042151 TK.Half.Life NA 3.749 hours 1compartment NA NA Human Human +DTXSID6042151 Css NA 0.2581 mg/L 3compartmentss NA 50% Human Human +DTXSID6042151 Css NA 1.919 mg/L 3compartmentss NA 95% Human Human +DTXSID6042151 Css NA 0.1725 mg/L PBTK NA 50% Human Human +DTXSID6042151 Css NA 1.197 mg/L PBTK NA 95% Human Human +DTXSID6042151 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042151 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042151 Vd NA 1.138 L/kg 1compartment NA NA Rat Human DTXSID6042151 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042151 TK.Half.Life NA 0.6809 hours 1compartment NA NA Rat Human -DTXSID6042151 Css NA 0.01875 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042151 Css NA 0.1028 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042151 Css NA 0.01316 mg/L PBTK NA 50% Rat Human -DTXSID6042151 Css NA 0.06813 mg/L PBTK NA 95% Rat Human -DTXSID6042157 Clint NA 6.973 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042157 Fup NA 0.1501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042157 Vd NA 1.338 L/kg 1compartment NA NA Human Human +DTXSID6042151 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human +DTXSID6042151 Css NA 0.03273 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042151 Css NA 0.2032 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042151 Css NA 0.0215 mg/L PBTK NA 50% Rat Human +DTXSID6042151 Css NA 0.1241 mg/L PBTK NA 95% Rat Human +DTXSID6042157 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042157 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042157 Vd NA 1.333 L/kg 1compartment NA NA Human Human DTXSID6042157 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042157 TK.Half.Life NA 6.156 hours 1compartment NA NA Human Human -DTXSID6042157 Css NA 0.5556 mg/L 3compartmentss NA 50% Human Human -DTXSID6042157 Css NA 3.711 mg/L 3compartmentss NA 95% Human Human -DTXSID6042157 Css NA 0.3808 mg/L PBTK NA 50% Human Human -DTXSID6042157 Css NA 2.326 mg/L PBTK NA 95% Human Human -DTXSID6042157 Clint NA 6.973 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042157 Fup NA 0.1501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042157 Vd NA 1.049 L/kg 1compartment NA NA Rat Human +DTXSID6042157 TK.Half.Life NA 2.795 hours 1compartment NA NA Human Human +DTXSID6042157 Css NA 0.185 mg/L 3compartmentss NA 50% Human Human +DTXSID6042157 Css NA 1.367 mg/L 3compartmentss NA 95% Human Human +DTXSID6042157 Css NA 0.1263 mg/L PBTK NA 50% Human Human +DTXSID6042157 Css NA 0.8663 mg/L PBTK NA 95% Human Human +DTXSID6042157 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042157 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042157 Vd NA 1.046 L/kg 1compartment NA NA Rat Human DTXSID6042157 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042157 TK.Half.Life NA 2.525 hours 1compartment NA NA Rat Human -DTXSID6042157 Css NA 0.2918 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042157 Css NA 1.444 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042157 Css NA 0.19 mg/L PBTK NA 50% Rat Human -DTXSID6042157 Css NA 0.8657 mg/L PBTK NA 95% Rat Human -DTXSID6042232 Clint NA 15.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042232 Fup NA 0.3732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042232 Vd NA 2.759 L/kg 1compartment NA NA Human Human +DTXSID6042157 TK.Half.Life NA 1.134 hours 1compartment NA NA Rat Human +DTXSID6042157 Css NA 0.02372 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042157 Css NA 0.1447 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042157 Css NA 0.01594 mg/L PBTK NA 50% Rat Human +DTXSID6042157 Css NA 0.09075 mg/L PBTK NA 95% Rat Human +DTXSID6042232 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042232 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042232 Vd NA 1.354 L/kg 1compartment NA NA Human Human DTXSID6042232 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042232 TK.Half.Life NA 7.802 hours 1compartment NA NA Human Human -DTXSID6042232 Css NA 0.25 mg/L 3compartmentss NA 50% Human Human -DTXSID6042232 Css NA 1.517 mg/L 3compartmentss NA 95% Human Human -DTXSID6042232 Css NA 0.1888 mg/L PBTK NA 50% Human Human -DTXSID6042232 Css NA 1.071 mg/L PBTK NA 95% Human Human -DTXSID6042232 Clint NA 15.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042232 Fup NA 0.3732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042232 Vd NA 2.114 L/kg 1compartment NA NA Rat Human +DTXSID6042232 TK.Half.Life NA 1.396 hours 1compartment NA NA Human Human +DTXSID6042232 Css NA 0.04282 mg/L 3compartmentss NA 50% Human Human +DTXSID6042232 Css NA 0.3695 mg/L 3compartmentss NA 95% Human Human +DTXSID6042232 Css NA 0.03488 mg/L PBTK NA 50% Human Human +DTXSID6042232 Css NA 0.2662 mg/L PBTK NA 95% Human Human +DTXSID6042232 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042232 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042232 Vd NA 1.157 L/kg 1compartment NA NA Rat Human DTXSID6042232 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042232 TK.Half.Life NA 1.893 hours 1compartment NA NA Rat Human -DTXSID6042232 Css NA 0.1343 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042232 Css NA 0.6055 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042232 Css NA 0.09767 mg/L PBTK NA 50% Rat Human -DTXSID6042232 Css NA 0.4238 mg/L PBTK NA 95% Rat Human -DTXSID6042234 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042234 Fup NA 0.3512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042234 Vd NA 1.001 L/kg 1compartment NA NA Human Human +DTXSID6042232 TK.Half.Life NA 0.5835 hours 1compartment NA NA Rat Human +DTXSID6042232 Css NA 0.005247 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042232 Css NA 0.0347 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042232 Css NA 0.004348 mg/L PBTK NA 50% Rat Human +DTXSID6042232 Css NA 0.02511 mg/L PBTK NA 95% Rat Human +DTXSID6042234 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042234 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042234 Vd NA 1.177 L/kg 1compartment NA NA Human Human DTXSID6042234 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6042234 TK.Half.Life NA 19.79 hours 1compartment NA NA Human Human -DTXSID6042234 Css NA 2.135 mg/L 3compartmentss NA 50% Human Human -DTXSID6042234 Css NA 8.909 mg/L 3compartmentss NA 95% Human Human -DTXSID6042234 Css NA 1.632 mg/L PBTK NA 50% Human Human -DTXSID6042234 Css NA 5.793 mg/L PBTK NA 95% Human Human -DTXSID6042234 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042234 Fup NA 0.3512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042234 Vd NA 0.8816 L/kg 1compartment NA NA Rat Human +DTXSID6042234 TK.Half.Life NA 17.89 hours 1compartment NA NA Human Human +DTXSID6042234 Css NA 1.33 mg/L 3compartmentss NA 50% Human Human +DTXSID6042234 Css NA 6.567 mg/L 3compartmentss NA 95% Human Human +DTXSID6042234 Css NA 1.091 mg/L PBTK NA 50% Human Human +DTXSID6042234 Css NA 4.333 mg/L PBTK NA 95% Human Human +DTXSID6042234 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042234 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042234 Vd NA 1.04 L/kg 1compartment NA NA Rat Human DTXSID6042234 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042234 TK.Half.Life NA 5.631 hours 1compartment NA NA Rat Human -DTXSID6042234 Css NA 0.5822 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042234 Css NA 2.054 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042234 Css NA 0.4271 mg/L PBTK NA 50% Rat Human -DTXSID6042234 Css NA 1.246 mg/L PBTK NA 95% Rat Human -DTXSID6042280 Clint NA 33.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042280 Fup NA 0.0287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042280 Vd NA 2.05 L/kg 1compartment NA NA Human Human +DTXSID6042234 TK.Half.Life NA 5.023 hours 1compartment NA NA Rat Human +DTXSID6042234 Css NA 0.03241 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042234 Css NA 0.2033 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042234 Css NA 0.02673 mg/L PBTK NA 50% Rat Human +DTXSID6042234 Css NA 0.1349 mg/L PBTK NA 95% Rat Human +DTXSID6042280 Clint 168 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID6042280 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042280 Vd NA 1.726 L/kg 1compartment NA NA Human Human DTXSID6042280 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042280 TK.Half.Life NA 11.59 hours 1compartment NA NA Human Human -DTXSID6042280 Css NA 0.7907 mg/L 3compartmentss NA 50% Human Human -DTXSID6042280 Css NA 6.418 mg/L 3compartmentss NA 95% Human Human -DTXSID6042280 Css NA 0.5158 mg/L PBTK NA 50% Human Human -DTXSID6042280 Css NA 3.946 mg/L PBTK NA 95% Human Human -DTXSID6042280 Clint NA 33.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042280 Fup NA 0.0287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042280 Vd NA 1.528 L/kg 1compartment NA NA Rat Human +DTXSID6042280 TK.Half.Life NA 3.703 hours 1compartment NA NA Human Human +DTXSID6042280 Css NA 0.2071 mg/L 3compartmentss NA 50% Human Human +DTXSID6042280 Css NA 1.862 mg/L 3compartmentss NA 95% Human Human +DTXSID6042280 Css NA 0.1312 mg/L PBTK NA 50% Human Human +DTXSID6042280 Css NA 1.145 mg/L PBTK NA 95% Human Human +DTXSID6042280 Clint 168 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human +DTXSID6042280 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042280 Vd NA 1.279 L/kg 1compartment NA NA Rat Human DTXSID6042280 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042280 TK.Half.Life NA 3.687 hours 1compartment NA NA Rat Human -DTXSID6042280 Css NA 0.4388 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042280 Css NA 2.918 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042280 Css NA 0.2694 mg/L PBTK NA 50% Rat Human -DTXSID6042280 Css NA 1.704 mg/L PBTK NA 95% Rat Human -DTXSID6042282 Clint NA 4.608 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042282 Fup NA 0.2137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042282 Vd NA 1.134 L/kg 1compartment NA NA Human Human +DTXSID6042280 TK.Half.Life NA 1.291 hours 1compartment NA NA Rat Human +DTXSID6042280 Css NA 0.02771 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042280 Css NA 0.2255 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042280 Css NA 0.01705 mg/L PBTK NA 50% Rat Human +DTXSID6042280 Css NA 0.1324 mg/L PBTK NA 95% Rat Human +DTXSID6042282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042282 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042282 Vd NA 1.185 L/kg 1compartment NA NA Human Human DTXSID6042282 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042282 TK.Half.Life NA 5.008 hours 1compartment NA NA Human Human -DTXSID6042282 Css NA 0.4566 mg/L 3compartmentss NA 50% Human Human -DTXSID6042282 Css NA 2.551 mg/L 3compartmentss NA 95% Human Human -DTXSID6042282 Css NA 0.3247 mg/L PBTK NA 50% Human Human -DTXSID6042282 Css NA 1.671 mg/L PBTK NA 95% Human Human -DTXSID6042282 Clint NA 4.608 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042282 Fup NA 0.2137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042282 Vd NA 0.9264 L/kg 1compartment NA NA Rat Human +DTXSID6042282 TK.Half.Life NA 1.836 hours 1compartment NA NA Human Human +DTXSID6042282 Css NA 0.09604 mg/L 3compartmentss NA 50% Human Human +DTXSID6042282 Css NA 0.6672 mg/L 3compartmentss NA 95% Human Human +DTXSID6042282 Css NA 0.06928 mg/L PBTK NA 50% Human Human +DTXSID6042282 Css NA 0.4546 mg/L PBTK NA 95% Human Human +DTXSID6042282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042282 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042282 Vd NA 0.9684 L/kg 1compartment NA NA Rat Human DTXSID6042282 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042282 TK.Half.Life NA 2.192 hours 1compartment NA NA Rat Human -DTXSID6042282 Css NA 0.2318 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042282 Css NA 0.9046 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042282 Css NA 0.1578 mg/L PBTK NA 50% Rat Human -DTXSID6042282 Css NA 0.5624 mg/L PBTK NA 95% Rat Human -DTXSID6042315 Clint NA 0.5935 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042315 Fup NA 0.3898 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042315 Vd NA 0.6512 L/kg 1compartment NA NA Human Human +DTXSID6042282 TK.Half.Life NA 0.7756 hours 1compartment NA NA Rat Human +DTXSID6042282 Css NA 0.01193 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042282 Css NA 0.06621 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042282 Css NA 0.008562 mg/L PBTK NA 50% Rat Human +DTXSID6042282 Css NA 0.04394 mg/L PBTK NA 95% Rat Human +DTXSID6042315 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042315 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042315 Vd NA 0.4519 L/kg 1compartment NA NA Human Human DTXSID6042315 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042315 TK.Half.Life NA 5.613 hours 1compartment NA NA Human Human -DTXSID6042315 Css NA 0.9294 mg/L 3compartmentss NA 50% Human Human -DTXSID6042315 Css NA 4.363 mg/L 3compartmentss NA 95% Human Human -DTXSID6042315 Css NA 0.6959 mg/L PBTK NA 50% Human Human -DTXSID6042315 Css NA 2.789 mg/L PBTK NA 95% Human Human -DTXSID6042315 Clint NA 0.5935 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042315 Fup NA 0.3898 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042315 Vd NA 0.6281 L/kg 1compartment NA NA Rat Human +DTXSID6042315 TK.Half.Life NA 6.995 hours 1compartment NA NA Human Human +DTXSID6042315 Css NA 1.517 mg/L 3compartmentss NA 50% Human Human +DTXSID6042315 Css NA 6.644 mg/L 3compartmentss NA 95% Human Human +DTXSID6042315 Css NA 1.089 mg/L PBTK NA 50% Human Human +DTXSID6042315 Css NA 4.179 mg/L PBTK NA 95% Human Human +DTXSID6042315 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042315 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042315 Vd NA 0.4733 L/kg 1compartment NA NA Rat Human DTXSID6042315 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042315 TK.Half.Life NA 2.427 hours 1compartment NA NA Rat Human -DTXSID6042315 Css NA 0.3428 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042315 Css NA 1.335 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042315 Css NA 0.2442 mg/L PBTK NA 50% Rat Human -DTXSID6042315 Css NA 0.7946 mg/L PBTK NA 95% Rat Human -DTXSID6042365 Clint NA 19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042365 Fup NA 0.0646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042365 Vd NA 2.757 L/kg 1compartment NA NA Human Human +DTXSID6042315 TK.Half.Life NA 2.497 hours 1compartment NA NA Rat Human +DTXSID6042315 Css NA 0.02799 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042315 Css NA 0.1769 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042315 Css NA 0.01921 mg/L PBTK NA 50% Rat Human +DTXSID6042315 Css NA 0.1105 mg/L PBTK NA 95% Rat Human +DTXSID6042365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042365 Fup 0.0419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042365 Vd NA 2.57 L/kg 1compartment NA NA Human Human DTXSID6042365 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6042365 TK.Half.Life NA 23.77 hours 1compartment NA NA Human Human -DTXSID6042365 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human -DTXSID6042365 Css NA 6.532 mg/L 3compartmentss NA 95% Human Human -DTXSID6042365 Css NA 0.7428 mg/L PBTK NA 50% Human Human -DTXSID6042365 Css NA 4.331 mg/L PBTK NA 95% Human Human -DTXSID6042365 Clint NA 19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042365 Fup NA 0.0646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042365 Vd NA 2.074 L/kg 1compartment NA NA Rat Human +DTXSID6042365 TK.Half.Life NA 21.44 hours 1compartment NA NA Human Human +DTXSID6042365 Css NA 1.043 mg/L 3compartmentss NA 50% Human Human +DTXSID6042365 Css NA 7.389 mg/L 3compartmentss NA 95% Human Human +DTXSID6042365 Css NA 0.6982 mg/L PBTK NA 50% Human Human +DTXSID6042365 Css NA 4.761 mg/L PBTK NA 95% Human Human +DTXSID6042365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042365 Fup 0.0419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042365 Vd NA 1.927 L/kg 1compartment NA NA Rat Human DTXSID6042365 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6042365 TK.Half.Life NA 5.059 hours 1compartment NA NA Rat Human -DTXSID6042365 Css NA 0.5901 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042365 Css NA 2.997 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042365 Css NA 0.3844 mg/L PBTK NA 50% Rat Human -DTXSID6042365 Css NA 1.905 mg/L PBTK NA 95% Rat Human +DTXSID6042365 TK.Half.Life NA 5.2 hours 1compartment NA NA Rat Human +DTXSID6042365 Css NA 0.1367 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042365 Css NA 0.7282 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042365 Css NA 0.0905 mg/L PBTK NA 50% Rat Human +DTXSID6042365 Css NA 0.4748 mg/L PBTK NA 95% Rat Human DTXSID6042369 Clint NA 33.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6042369 Fup NA 0.1802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042369 Vd NA 0.9522 L/kg 1compartment NA NA Human Human -DTXSID6042369 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042369 TK.Half.Life NA 1.227 hours 1compartment NA NA Human Human -DTXSID6042369 Css NA 0.06954 mg/L 3compartmentss NA 50% Human Human -DTXSID6042369 Css NA 0.5125 mg/L 3compartmentss NA 95% Human Human -DTXSID6042369 Css NA 0.05786 mg/L PBTK NA 50% Human Human -DTXSID6042369 Css NA 0.3819 mg/L PBTK NA 95% Human Human +DTXSID6042369 Vd NA 3.7 L/kg 1compartment NA NA Human Human +DTXSID6042369 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID6042369 TK.Half.Life NA 45.72 hours 1compartment NA NA Human Human +DTXSID6042369 Css NA 1.322 mg/L 3compartmentss NA 50% Human Human +DTXSID6042369 Css NA 9.059 mg/L 3compartmentss NA 95% Human Human +DTXSID6042369 Css NA 0.9734 mg/L PBTK NA 50% Human Human +DTXSID6042369 Css NA 6.377 mg/L PBTK NA 95% Human Human DTXSID6042369 Clint NA 33.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6042369 Fup NA 0.1802 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042369 Vd NA 0.8691 L/kg 1compartment NA NA Rat Human -DTXSID6042369 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042369 TK.Half.Life NA 0.6086 hours 1compartment NA NA Rat Human -DTXSID6042369 Css NA 0.03729 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042369 Css NA 0.2171 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042369 Css NA 0.02996 mg/L PBTK NA 50% Rat Human -DTXSID6042369 Css NA 0.1545 mg/L PBTK NA 95% Rat Human -DTXSID6042440 Clint NA 8.052 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042440 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042440 Vd NA 2.696 L/kg 1compartment NA NA Human Human -DTXSID6042440 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID6042440 TK.Half.Life NA 115.5 hours 1compartment NA NA Human Human -DTXSID6042440 Css NA 6.097 mg/L 3compartmentss NA 50% Human Human -DTXSID6042440 Css NA 40.63 mg/L 3compartmentss NA 95% Human Human -DTXSID6042440 Css NA 4.067 mg/L PBTK NA 50% Human Human -DTXSID6042440 Css NA 25.86 mg/L PBTK NA 95% Human Human -DTXSID6042440 Clint NA 8.052 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042440 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042440 Vd NA 2.013 L/kg 1compartment NA NA Rat Human -DTXSID6042440 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID6042440 TK.Half.Life NA 23.89 hours 1compartment NA NA Rat Human -DTXSID6042440 Css NA 3.386 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042440 Css NA 17.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042440 Css NA 2.153 mg/L PBTK NA 50% Rat Human -DTXSID6042440 Css NA 10.99 mg/L PBTK NA 95% Rat Human -DTXSID6042448 Clint NA 81.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042448 Fup NA 0.1991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042448 Vd NA 2.838 L/kg 1compartment NA NA Human Human +DTXSID6042369 Vd NA 2.793 L/kg 1compartment NA NA Rat Human +DTXSID6042369 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6042369 TK.Half.Life NA 6.49 hours 1compartment NA NA Rat Human +DTXSID6042369 Css NA 0.1711 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042369 Css NA 0.9193 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042369 Css NA 0.1251 mg/L PBTK NA 50% Rat Human +DTXSID6042369 Css NA 0.662 mg/L PBTK NA 95% Rat Human +DTXSID6042440 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042440 Fup 0.0149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042440 Vd NA 2.712 L/kg 1compartment NA NA Human Human +DTXSID6042440 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID6042440 TK.Half.Life NA 44.66 hours 1compartment NA NA Human Human +DTXSID6042440 Css NA 2.209 mg/L 3compartmentss NA 50% Human Human +DTXSID6042440 Css NA 15.59 mg/L 3compartmentss NA 95% Human Human +DTXSID6042440 Css NA 1.485 mg/L PBTK NA 50% Human Human +DTXSID6042440 Css NA 10.09 mg/L PBTK NA 95% Human Human +DTXSID6042440 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042440 Fup 0.0149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042440 Vd NA 2.026 L/kg 1compartment NA NA Rat Human +DTXSID6042440 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6042440 TK.Half.Life NA 9.387 hours 1compartment NA NA Rat Human +DTXSID6042440 Css NA 0.2878 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042440 Css NA 1.701 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042440 Css NA 0.1896 mg/L PBTK NA 50% Rat Human +DTXSID6042440 Css NA 1.09 mg/L PBTK NA 95% Rat Human +DTXSID6042448 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042448 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042448 Vd NA 2.762 L/kg 1compartment NA NA Human Human DTXSID6042448 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042448 TK.Half.Life NA 4.696 hours 1compartment NA NA Human Human -DTXSID6042448 Css NA 0.106 mg/L 3compartmentss NA 50% Human Human -DTXSID6042448 Css NA 0.6936 mg/L 3compartmentss NA 95% Human Human -DTXSID6042448 Css NA 0.07613 mg/L PBTK NA 50% Human Human -DTXSID6042448 Css NA 0.4764 mg/L PBTK NA 95% Human Human -DTXSID6042448 Clint NA 81.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042448 Fup NA 0.1991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042448 Vd NA 2.148 L/kg 1compartment NA NA Rat Human +DTXSID6042448 TK.Half.Life NA 5.212 hours 1compartment NA NA Human Human +DTXSID6042448 Css NA 0.1347 mg/L 3compartmentss NA 50% Human Human +DTXSID6042448 Css NA 0.8376 mg/L 3compartmentss NA 95% Human Human +DTXSID6042448 Css NA 0.1037 mg/L PBTK NA 50% Human Human +DTXSID6042448 Css NA 0.6005 mg/L PBTK NA 95% Human Human +DTXSID6042448 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042448 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042448 Vd NA 2.131 L/kg 1compartment NA NA Rat Human DTXSID6042448 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042448 TK.Half.Life NA 1.208 hours 1compartment NA NA Rat Human -DTXSID6042448 Css NA 0.05942 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042448 Css NA 0.3216 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042448 Css NA 0.041 mg/L PBTK NA 50% Rat Human -DTXSID6042448 Css NA 0.2134 mg/L PBTK NA 95% Rat Human -DTXSID6042498 Clint NA 19.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042498 Fup NA 0.467 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042498 Vd NA 1285 L/kg 1compartment NA NA Human Human -DTXSID6042498 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6042498 TK.Half.Life NA 41910 hours 1compartment NA NA Human Human -DTXSID6042498 Css NA 0.0126 mg/L 3compartmentss NA 50% Human Human -DTXSID6042498 Css NA 0.07823 mg/L 3compartmentss NA 95% Human Human -DTXSID6042498 Css NA 2.69 mg/L PBTK NA 50% Human Human -DTXSID6042498 Css NA 14.81 mg/L PBTK NA 95% Human Human -DTXSID6042498 Clint NA 19.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042498 Fup NA 0.467 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042498 Vd NA 1182 L/kg 1compartment NA NA Rat Human -DTXSID6042498 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6042498 TK.Half.Life NA 6448 hours 1compartment NA NA Rat Human -DTXSID6042498 Css NA 0.00644 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042498 Css NA 0.02835 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042498 Css NA 1.453 mg/L PBTK NA 50% Rat Human -DTXSID6042498 Css NA 6.373 mg/L PBTK NA 95% Rat Human -DTXSID6042521 Clint NA 1.125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042521 Fup NA 0.5669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042521 Vd NA 0.655 L/kg 1compartment NA NA Human Human +DTXSID6042448 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Human +DTXSID6042448 Css NA 0.01662 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042448 Css NA 0.08777 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042448 Css NA 0.01283 mg/L PBTK NA 50% Rat Human +DTXSID6042448 Css NA 0.06313 mg/L PBTK NA 95% Rat Human +DTXSID6042521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042521 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042521 Vd NA 0.4245 L/kg 1compartment NA NA Human Human DTXSID6042521 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042521 TK.Half.Life NA 2.817 hours 1compartment NA NA Human Human -DTXSID6042521 Css NA 0.4685 mg/L 3compartmentss NA 50% Human Human -DTXSID6042521 Css NA 3.429 mg/L 3compartmentss NA 95% Human Human -DTXSID6042521 Css NA 0.362 mg/L PBTK NA 50% Human Human -DTXSID6042521 Css NA 2.181 mg/L PBTK NA 95% Human Human -DTXSID6042521 Clint NA 1.125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042521 Fup NA 0.5669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042521 Vd NA 0.651 L/kg 1compartment NA NA Rat Human +DTXSID6042521 TK.Half.Life NA 0.6222 hours 1compartment NA NA Human Human +DTXSID6042521 Css NA 0.08515 mg/L 3compartmentss NA 50% Human Human +DTXSID6042521 Css NA 0.6103 mg/L 3compartmentss NA 95% Human Human +DTXSID6042521 Css NA 0.05703 mg/L PBTK NA 50% Human Human +DTXSID6042521 Css NA 0.3918 mg/L PBTK NA 95% Human Human +DTXSID6042521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042521 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042521 Vd NA 0.42 L/kg 1compartment NA NA Rat Human DTXSID6042521 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042521 TK.Half.Life NA 1.375 hours 1compartment NA NA Rat Human -DTXSID6042521 Css NA 0.1868 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042521 Css NA 1.181 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042521 Css NA 0.1397 mg/L PBTK NA 50% Rat Human -DTXSID6042521 Css NA 0.69 mg/L PBTK NA 95% Rat Human -DTXSID6042579 Clint NA 34.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042579 Fup NA 0.1091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042579 Vd NA 1.918 L/kg 1compartment NA NA Human Human -DTXSID6042579 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042579 TK.Half.Life NA 4.234 hours 1compartment NA NA Human Human -DTXSID6042579 Css NA 0.2076 mg/L 3compartmentss NA 50% Human Human -DTXSID6042579 Css NA 1.582 mg/L 3compartmentss NA 95% Human Human -DTXSID6042579 Css NA 0.1415 mg/L PBTK NA 50% Human Human -DTXSID6042579 Css NA 1.019 mg/L PBTK NA 95% Human Human -DTXSID6042579 Clint NA 34.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042579 Fup NA 0.1091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042579 Vd NA 1.462 L/kg 1compartment NA NA Rat Human +DTXSID6042521 TK.Half.Life NA 0.3312 hours 1compartment NA NA Rat Human +DTXSID6042521 Css NA 0.01079 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042521 Css NA 0.05794 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042521 Css NA 0.007099 mg/L PBTK NA 50% Rat Human +DTXSID6042521 Css NA 0.03655 mg/L PBTK NA 95% Rat Human +DTXSID6042579 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042579 Fup 0.0968 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042579 Vd NA 1.804 L/kg 1compartment NA NA Human Human +DTXSID6042579 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6042579 TK.Half.Life NA 15.3 hours 1compartment NA NA Human Human +DTXSID6042579 Css NA 1.134 mg/L 3compartmentss NA 50% Human Human +DTXSID6042579 Css NA 7.199 mg/L 3compartmentss NA 95% Human Human +DTXSID6042579 Css NA 0.7607 mg/L PBTK NA 50% Human Human +DTXSID6042579 Css NA 4.534 mg/L PBTK NA 95% Human Human +DTXSID6042579 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042579 Fup 0.0968 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042579 Vd NA 1.374 L/kg 1compartment NA NA Rat Human DTXSID6042579 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042579 TK.Half.Life NA 1.46 hours 1compartment NA NA Rat Human -DTXSID6042579 Css NA 0.1175 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042579 Css NA 0.6585 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042579 Css NA 0.07594 mg/L PBTK NA 50% Rat Human -DTXSID6042579 Css NA 0.4041 mg/L PBTK NA 95% Rat Human -DTXSID6042602 Clint NA 94.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042602 Fup NA 0.0242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6042602 Vd NA 1.575 L/kg 1compartment NA NA Human Human +DTXSID6042579 TK.Half.Life NA 5.295 hours 1compartment NA NA Rat Human +DTXSID6042579 Css NA 0.1378 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042579 Css NA 0.653 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042579 Css NA 0.09178 mg/L PBTK NA 50% Rat Human +DTXSID6042579 Css NA 0.3996 mg/L PBTK NA 95% Rat Human +DTXSID6042602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042602 Fup 0.0249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6042602 Vd NA 2.386 L/kg 1compartment NA NA Human Human DTXSID6042602 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6042602 TK.Half.Life NA 1.499 hours 1compartment NA NA Human Human -DTXSID6042602 Css NA 0.03355 mg/L 3compartmentss NA 50% Human Human -DTXSID6042602 Css NA 0.3789 mg/L 3compartmentss NA 95% Human Human -DTXSID6042602 Css NA 0.02478 mg/L PBTK NA 50% Human Human -DTXSID6042602 Css NA 0.2482 mg/L PBTK NA 95% Human Human -DTXSID6042602 Clint NA 94.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042602 Fup NA 0.0242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6042602 Vd NA 1.485 L/kg 1compartment NA NA Rat Human +DTXSID6042602 TK.Half.Life NA 4.176 hours 1compartment NA NA Human Human +DTXSID6042602 Css NA 0.1466 mg/L 3compartmentss NA 50% Human Human +DTXSID6042602 Css NA 1.658 mg/L 3compartmentss NA 95% Human Human +DTXSID6042602 Css NA 0.1186 mg/L PBTK NA 50% Human Human +DTXSID6042602 Css NA 1.132 mg/L PBTK NA 95% Human Human +DTXSID6042602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042602 Fup 0.0249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6042602 Vd NA 2.145 L/kg 1compartment NA NA Rat Human DTXSID6042602 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6042602 TK.Half.Life NA 0.6945 hours 1compartment NA NA Rat Human -DTXSID6042602 Css NA 0.01906 mg/L 3compartmentss NA 50% Rat Human -DTXSID6042602 Css NA 0.1924 mg/L 3compartmentss NA 95% Rat Human -DTXSID6042602 Css NA 0.01334 mg/L PBTK NA 50% Rat Human -DTXSID6042602 Css NA 0.1137 mg/L PBTK NA 95% Rat Human +DTXSID6042602 TK.Half.Life NA 1.981 hours 1compartment NA NA Rat Human +DTXSID6042602 Css NA 0.01886 mg/L 3compartmentss NA 50% Rat Human +DTXSID6042602 Css NA 0.1789 mg/L 3compartmentss NA 95% Rat Human +DTXSID6042602 Css NA 0.01523 mg/L PBTK NA 50% Rat Human +DTXSID6042602 Css NA 0.1205 mg/L PBTK NA 95% Rat Human +DTXSID60432080 Clint 2.362 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60432080 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60432080 Vd NA 1.019 L/kg 1compartment NA NA Human Human +DTXSID60432080 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID60432080 TK.Half.Life NA 11.34 hours 1compartment NA NA Human Human +DTXSID60432080 Css NA 1.505 mg/L 3compartmentss NA 50% Human Human +DTXSID60432080 Css NA 8.668 mg/L 3compartmentss NA 95% Human Human +DTXSID60432080 Css NA 1.006 mg/L PBTK NA 50% Human Human +DTXSID60432080 Css NA 5.264 mg/L PBTK NA 95% Human Human +DTXSID60432080 Clint 2.362 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60432080 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60432080 Vd NA 0.8155 L/kg 1compartment NA NA Rat Human +DTXSID60432080 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60432080 TK.Half.Life NA 4.715 hours 1compartment NA NA Rat Human +DTXSID60432080 Css NA 0.1684 mg/L 3compartmentss NA 50% Rat Human +DTXSID60432080 Css NA 0.7213 mg/L 3compartmentss NA 95% Rat Human +DTXSID60432080 Css NA 0.1098 mg/L PBTK NA 50% Rat Human +DTXSID60432080 Css NA 0.4268 mg/L PBTK NA 95% Rat Human DTXSID6043709 Clint 29.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6043709 Fup 0.0741 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6043709 Vd NA 3.115 L/kg 1compartment NA NA Human Human +DTXSID6043709 Vd NA 1.481 L/kg 1compartment NA NA Human Human DTXSID6043709 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6043709 TK.Half.Life NA 2.157 hours 1compartment NA NA Human Human -DTXSID6043709 Css NA 0.01538 mg/L 3compartmentss NA 50% Human Human -DTXSID6043709 Css NA 0.1263 mg/L 3compartmentss NA 95% Human Human -DTXSID6043709 Css NA 0.01688 mg/L PBTK NA 50% Human Human -DTXSID6043709 Css NA 0.1145 mg/L PBTK NA 95% Human Human +DTXSID6043709 TK.Half.Life NA 2.489 hours 1compartment NA NA Human Human +DTXSID6043709 Css NA 0.09942 mg/L 3compartmentss NA 50% Human Human +DTXSID6043709 Css NA 0.8227 mg/L 3compartmentss NA 95% Human Human +DTXSID6043709 Css NA 0.08008 mg/L PBTK NA 50% Human Human +DTXSID6043709 Css NA 0.5835 mg/L PBTK NA 95% Human Human DTXSID6043709 Clint 29.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6043709 Fup 0.0741 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6043709 Vd NA 2.977 L/kg 1compartment NA NA Rat Human +DTXSID6043709 Vd NA 1.446 L/kg 1compartment NA NA Rat Human DTXSID6043709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6043709 TK.Half.Life NA 1.008 hours 1compartment NA NA Rat Human -DTXSID6043709 Css NA 0.008228 mg/L 3compartmentss NA 50% Rat Human -DTXSID6043709 Css NA 0.05675 mg/L 3compartmentss NA 95% Rat Human -DTXSID6043709 Css NA 0.009025 mg/L PBTK NA 50% Rat Human -DTXSID6043709 Css NA 0.05195 mg/L PBTK NA 95% Rat Human -DTXSID6043913 Clint NA 20.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6043913 Fup NA 0.4866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6043913 Vd NA 0.95 L/kg 1compartment NA NA Human Human +DTXSID6043709 TK.Half.Life NA 1.421 hours 1compartment NA NA Rat Human +DTXSID6043709 Css NA 0.01286 mg/L 3compartmentss NA 50% Rat Human +DTXSID6043709 Css NA 0.08238 mg/L 3compartmentss NA 95% Rat Human +DTXSID6043709 Css NA 0.01046 mg/L PBTK NA 50% Rat Human +DTXSID6043709 Css NA 0.05846 mg/L PBTK NA 95% Rat Human +DTXSID6043913 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6043913 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6043913 Vd NA 0.6564 L/kg 1compartment NA NA Human Human DTXSID6043913 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6043913 TK.Half.Life NA 0.969 hours 1compartment NA NA Human Human -DTXSID6043913 Css NA 0.04466 mg/L 3compartmentss NA 50% Human Human -DTXSID6043913 Css NA 0.3669 mg/L 3compartmentss NA 95% Human Human -DTXSID6043913 Css NA 0.03535 mg/L PBTK NA 50% Human Human -DTXSID6043913 Css NA 0.2529 mg/L PBTK NA 95% Human Human -DTXSID6043913 Clint NA 20.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6043913 Fup NA 0.4866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6043913 Vd NA 0.8625 L/kg 1compartment NA NA Rat Human +DTXSID6043913 TK.Half.Life NA 2.588 hours 1compartment NA NA Human Human +DTXSID6043913 Css NA 0.4018 mg/L 3compartmentss NA 50% Human Human +DTXSID6043913 Css NA 2.338 mg/L 3compartmentss NA 95% Human Human +DTXSID6043913 Css NA 0.2716 mg/L PBTK NA 50% Human Human +DTXSID6043913 Css NA 1.478 mg/L PBTK NA 95% Human Human +DTXSID6043913 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6043913 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6043913 Vd NA 0.575 L/kg 1compartment NA NA Rat Human DTXSID6043913 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6043913 TK.Half.Life NA 0.4421 hours 1compartment NA NA Rat Human -DTXSID6043913 Css NA 0.02324 mg/L 3compartmentss NA 50% Rat Human -DTXSID6043913 Css NA 0.1607 mg/L 3compartmentss NA 95% Rat Human -DTXSID6043913 Css NA 0.01778 mg/L PBTK NA 50% Rat Human -DTXSID6043913 Css NA 0.1058 mg/L PBTK NA 95% Rat Human +DTXSID6043913 TK.Half.Life NA 1.319 hours 1compartment NA NA Rat Human +DTXSID6043913 Css NA 0.04853 mg/L 3compartmentss NA 50% Rat Human +DTXSID6043913 Css NA 0.2072 mg/L 3compartmentss NA 95% Rat Human +DTXSID6043913 Css NA 0.03218 mg/L PBTK NA 50% Rat Human +DTXSID6043913 Css NA 0.1267 mg/L PBTK NA 95% Rat Human DTXSID6043915 Clint 195 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6043915 Fup 0.0175 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6043915 Vd NA 3.066 L/kg 1compartment NA NA Human Human +DTXSID6043915 Vd NA 3.08 L/kg 1compartment NA NA Human Human DTXSID6043915 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6043915 TK.Half.Life NA 10.58 hours 1compartment NA NA Human Human -DTXSID6043915 Css NA 0.3221 mg/L 3compartmentss NA 50% Human Human -DTXSID6043915 Css NA 2.201 mg/L 3compartmentss NA 95% Human Human -DTXSID6043915 Css NA 0.2234 mg/L PBTK NA 50% Human Human -DTXSID6043915 Css NA 1.467 mg/L PBTK NA 95% Human Human +DTXSID6043915 TK.Half.Life NA 10.99 hours 1compartment NA NA Human Human +DTXSID6043915 Css NA 0.3254 mg/L 3compartmentss NA 50% Human Human +DTXSID6043915 Css NA 2.172 mg/L 3compartmentss NA 95% Human Human +DTXSID6043915 Css NA 0.2262 mg/L PBTK NA 50% Human Human +DTXSID6043915 Css NA 1.443 mg/L PBTK NA 95% Human Human DTXSID6043915 Clint 195 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6043915 Fup 0.0175 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6043915 Vd NA 2.296 L/kg 1compartment NA NA Rat Human +DTXSID6043915 Vd NA 2.307 L/kg 1compartment NA NA Rat Human DTXSID6043915 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6043915 TK.Half.Life NA 1.954 hours 1compartment NA NA Rat Human -DTXSID6043915 Css NA 0.1828 mg/L 3compartmentss NA 50% Rat Human -DTXSID6043915 Css NA 0.9826 mg/L 3compartmentss NA 95% Rat Human -DTXSID6043915 Css NA 0.1206 mg/L PBTK NA 50% Rat Human -DTXSID6043915 Css NA 0.6322 mg/L PBTK NA 95% Rat Human +DTXSID6043915 TK.Half.Life NA 1.989 hours 1compartment NA NA Rat Human +DTXSID6043915 Css NA 0.0423 mg/L 3compartmentss NA 50% Rat Human +DTXSID6043915 Css NA 0.2462 mg/L 3compartmentss NA 95% Rat Human +DTXSID6043915 Css NA 0.02906 mg/L PBTK NA 50% Rat Human +DTXSID6043915 Css NA 0.1652 mg/L PBTK NA 95% Rat Human DTXSID6043917 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6043917 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6043917 Vd NA 0.5748 L/kg 1compartment NA NA Human Human +DTXSID6043917 Vd NA 0.567 L/kg 1compartment NA NA Human Human DTXSID6043917 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6043917 TK.Half.Life NA 3.721 hours 1compartment NA NA Human Human -DTXSID6043917 Css NA 0.8974 mg/L 3compartmentss NA 50% Human Human -DTXSID6043917 Css NA 5.642 mg/L 3compartmentss NA 95% Human Human -DTXSID6043917 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID6043917 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID6043917 TK.Half.Life NA 3.669 hours 1compartment NA NA Human Human +DTXSID6043917 Css NA 0.76 mg/L 3compartmentss NA 50% Human Human +DTXSID6043917 Css NA 5.195 mg/L 3compartmentss NA 95% Human Human +DTXSID6043917 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID6043917 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID6043917 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6043917 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6043917 Vd NA 0.6152 L/kg 1compartment NA NA Rat Human +DTXSID6043917 Vd NA 0.6088 L/kg 1compartment NA NA Rat Human DTXSID6043917 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6043917 TK.Half.Life NA 1.356 hours 1compartment NA NA Rat Human -DTXSID6043917 Css NA 0.2273 mg/L 3compartmentss NA 50% Rat Human -DTXSID6043917 Css NA 1.364 mg/L 3compartmentss NA 95% Rat Human -DTXSID6043917 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID6043917 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID6043917 TK.Half.Life NA 1.342 hours 1compartment NA NA Rat Human +DTXSID6043917 Css NA 0.01399 mg/L 3compartmentss NA 50% Rat Human +DTXSID6043917 Css NA 0.103 mg/L 3compartmentss NA 95% Rat Human +DTXSID6043917 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID6043917 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID6043919 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6043919 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6043919 Vd NA 0.7024 L/kg 1compartment NA NA Human Human DTXSID6043919 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6043919 TK.Half.Life NA 4.545 hours 1compartment NA NA Human Human -DTXSID6043919 Css NA 0.8465 mg/L 3compartmentss NA 50% Human Human -DTXSID6043919 Css NA 5.575 mg/L 3compartmentss NA 95% Human Human -DTXSID6043919 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID6043919 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID6043919 Css NA 0.7135 mg/L 3compartmentss NA 50% Human Human +DTXSID6043919 Css NA 5.069 mg/L 3compartmentss NA 95% Human Human +DTXSID6043919 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID6043919 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID6043919 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6043919 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6043919 Vd NA 0.7513 L/kg 1compartment NA NA Rat Human DTXSID6043919 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6043919 TK.Half.Life NA 1.656 hours 1compartment NA NA Rat Human -DTXSID6043919 Css NA 0.2127 mg/L 3compartmentss NA 50% Rat Human -DTXSID6043919 Css NA 1.338 mg/L 3compartmentss NA 95% Rat Human -DTXSID6043919 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID6043919 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID6043919 Css NA 0.0131 mg/L 3compartmentss NA 50% Rat Human +DTXSID6043919 Css NA 0.1002 mg/L 3compartmentss NA 95% Rat Human +DTXSID6043919 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID6043919 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID6044012 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6044012 Fup 0.028 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6044012 Vd NA 2.84 L/kg 1compartment NA NA Human Human -DTXSID6044012 Days.Css NA 748 Days PBTK NA NA Human Human +DTXSID6044012 Days.Css NA 651 Days PBTK NA NA Human Human DTXSID6044012 TK.Half.Life NA 2803 hours 1compartment NA NA Human Human -DTXSID6044012 Css NA 126.3 mg/L 3compartmentss NA 50% Human Human -DTXSID6044012 Css NA 433.2 mg/L 3compartmentss NA 95% Human Human -DTXSID6044012 Css NA 88.32 mg/L PBTK NA 50% Human Human -DTXSID6044012 Css NA 276.8 mg/L PBTK NA 95% Human Human +DTXSID6044012 Css NA 119.5 mg/L 3compartmentss NA 50% Human Human +DTXSID6044012 Css NA 413.4 mg/L 3compartmentss NA 95% Human Human +DTXSID6044012 Css NA 83.12 mg/L PBTK NA 50% Human Human +DTXSID6044012 Css NA 257.5 mg/L PBTK NA 95% Human Human DTXSID6044012 Clint 1756 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID6044012 Fup 0.051 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID6044012 Vd NA 2.364 L/kg 1compartment NA NA Rat Rat DTXSID6044012 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID6044012 TK.Half.Life NA 0.92 hours 1compartment NA NA Rat Rat -DTXSID6044012 Css NA 0.004914 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6044012 Css NA 0.02736 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6044012 Css NA 0.003354 mg/L PBTK NA 50% Rat Rat -DTXSID6044012 Css NA 0.0183 mg/L PBTK NA 95% Rat Rat -DTXSID6044014 Clint NA 2.104 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044014 Fup NA 0.5134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044014 Vd NA 3.068 L/kg 1compartment NA NA Human Human +DTXSID6044012 Css NA 0.0006854 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6044012 Css NA 0.004979 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6044012 Css NA 0.000491 mg/L PBTK NA 50% Rat Rat +DTXSID6044012 Css NA 0.003273 mg/L PBTK NA 95% Rat Rat +DTXSID6044014 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044014 Fup 0.513 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044014 Vd NA 3.275 L/kg 1compartment NA NA Human Human DTXSID6044014 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044014 TK.Half.Life NA 9.233 hours 1compartment NA NA Human Human -DTXSID6044014 Css NA 0.2106 mg/L 3compartmentss NA 50% Human Human -DTXSID6044014 Css NA 1.673 mg/L 3compartmentss NA 95% Human Human -DTXSID6044014 Css NA 0.2448 mg/L PBTK NA 50% Human Human -DTXSID6044014 Css NA 1.325 mg/L PBTK NA 95% Human Human -DTXSID6044014 Clint NA 2.104 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044014 Fup NA 0.5134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044014 Vd NA 3.115 L/kg 1compartment NA NA Rat Human +DTXSID6044014 TK.Half.Life NA 4.683 hours 1compartment NA NA Human Human +DTXSID6044014 Css NA 0.07925 mg/L 3compartmentss NA 50% Human Human +DTXSID6044014 Css NA 0.7648 mg/L 3compartmentss NA 95% Human Human +DTXSID6044014 Css NA 0.09523 mg/L PBTK NA 50% Human Human +DTXSID6044014 Css NA 0.636 mg/L PBTK NA 95% Human Human +DTXSID6044014 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044014 Fup 0.513 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044014 Vd NA 3.33 L/kg 1compartment NA NA Rat Human DTXSID6044014 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044014 TK.Half.Life NA 5.1 hours 1compartment NA NA Rat Human -DTXSID6044014 Css NA 0.09012 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044014 Css NA 0.6512 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044014 Css NA 0.1056 mg/L PBTK NA 50% Rat Human -DTXSID6044014 Css NA 0.4622 mg/L PBTK NA 95% Rat Human -DTXSID6044199 Clint NA 282.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044199 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044199 Vd NA 1548 L/kg 1compartment NA NA Human Human -DTXSID6044199 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID6044199 TK.Half.Life NA 3567 hours 1compartment NA NA Human Human -DTXSID6044199 Css NA 0.0007588 mg/L 3compartmentss NA 50% Human Human -DTXSID6044199 Css NA 0.004682 mg/L 3compartmentss NA 95% Human Human -DTXSID6044199 Css NA 0.193 mg/L PBTK NA 50% Human Human -DTXSID6044199 Css NA 1.06 mg/L PBTK NA 95% Human Human -DTXSID6044199 Clint NA 282.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044199 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044199 Vd NA 1428 L/kg 1compartment NA NA Rat Human -DTXSID6044199 Days.Css NA 630 Days PBTK NA NA Rat Human -DTXSID6044199 TK.Half.Life NA 600.1 hours 1compartment NA NA Rat Human -DTXSID6044199 Css NA 0.0003837 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044199 Css NA 0.001627 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044199 Css NA 0.1046 mg/L PBTK NA 50% Rat Human -DTXSID6044199 Css NA 0.4403 mg/L PBTK NA 95% Rat Human -DTXSID6044226 Clint NA 7.218 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6044014 TK.Half.Life NA 2.726 hours 1compartment NA NA Rat Human +DTXSID6044014 Css NA 0.008932 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044014 Css NA 0.07181 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044014 Css NA 0.01109 mg/L PBTK NA 50% Rat Human +DTXSID6044014 Css NA 0.05672 mg/L PBTK NA 95% Rat Human +DTXSID6044018 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044018 Fup 0.875 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044018 Vd NA 0.7255 L/kg 1compartment NA NA Human Human +DTXSID6044018 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044018 TK.Half.Life NA 5.365 hours 1compartment NA NA Human Human +DTXSID6044018 Css NA 0.7909 mg/L 3compartmentss NA 50% Human Human +DTXSID6044018 Css NA 4.702 mg/L 3compartmentss NA 95% Human Human +DTXSID6044018 Css NA 0.6615 mg/L PBTK NA 50% Human Human +DTXSID6044018 Css NA 3.052 mg/L PBTK NA 95% Human Human +DTXSID6044018 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044018 Fup 0.875 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044018 Vd NA 0.7493 L/kg 1compartment NA NA Rat Human +DTXSID6044018 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6044018 TK.Half.Life NA 1.888 hours 1compartment NA NA Rat Human +DTXSID6044018 Css NA 0.01488 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044018 Css NA 0.1059 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044018 Css NA 0.01196 mg/L PBTK NA 50% Rat Human +DTXSID6044018 Css NA 0.06978 mg/L PBTK NA 95% Rat Human +DTXSID6044199 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044199 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044199 Vd NA 6182 L/kg 1compartment NA NA Human Human +DTXSID6044199 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID6044199 TK.Half.Life NA 181000 hours 1compartment NA NA Human Human +DTXSID6044199 Css NA 0.002105 mg/L 3compartmentss NA 50% Human Human +DTXSID6044199 Css NA 0.01401 mg/L 3compartmentss NA 95% Human Human +DTXSID6044199 Css NA 2.371 mg/L PBTK NA 50% Human Human +DTXSID6044199 Css NA 14.06 mg/L PBTK NA 95% Human Human +DTXSID6044199 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044199 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044199 Vd NA 5795 L/kg 1compartment NA NA Rat Human +DTXSID6044199 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID6044199 TK.Half.Life NA 28800 hours 1compartment NA NA Rat Human +DTXSID6044199 Css NA 0.0002447 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044199 Css NA 0.001127 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044199 Css NA 0.3056 mg/L PBTK NA 50% Rat Human +DTXSID6044199 Css NA 1.489 mg/L PBTK NA 95% Rat Human +DTXSID6044226 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6044226 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6044226 Vd NA 0.708 L/kg 1compartment NA NA Human Human -DTXSID6044226 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6044226 TK.Half.Life NA 16.78 hours 1compartment NA NA Human Human -DTXSID6044226 Css NA 4.215 mg/L 3compartmentss NA 50% Human Human -DTXSID6044226 Css NA 36.12 mg/L 3compartmentss NA 95% Human Human -DTXSID6044226 Css NA 2.544 mg/L PBTK NA 50% Human Human -DTXSID6044226 Css NA 20.99 mg/L PBTK NA 95% Human Human -DTXSID6044226 Clint NA 7.218 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6044226 Vd NA 0.5456 L/kg 1compartment NA NA Human Human +DTXSID6044226 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044226 TK.Half.Life NA 4.885 hours 1compartment NA NA Human Human +DTXSID6044226 Css NA 1.484 mg/L 3compartmentss NA 50% Human Human +DTXSID6044226 Css NA 14.48 mg/L 3compartmentss NA 95% Human Human +DTXSID6044226 Css NA 0.8852 mg/L PBTK NA 50% Human Human +DTXSID6044226 Css NA 8.342 mg/L PBTK NA 95% Human Human +DTXSID6044226 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6044226 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6044226 Vd NA 0.533 L/kg 1compartment NA NA Rat Human +DTXSID6044226 Vd NA 0.4192 L/kg 1compartment NA NA Rat Human DTXSID6044226 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044226 TK.Half.Life NA 7.692 hours 1compartment NA NA Rat Human -DTXSID6044226 Css NA 2.302 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044226 Css NA 15.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044226 Css NA 1.295 mg/L PBTK NA 50% Rat Human -DTXSID6044226 Css NA 8.212 mg/L PBTK NA 95% Rat Human -DTXSID6044272 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044272 Fup NA 0.1273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044272 Vd NA 0.7619 L/kg 1compartment NA NA Human Human -DTXSID6044272 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID6044272 TK.Half.Life NA 41.36 hours 1compartment NA NA Human Human -DTXSID6044272 Css NA 7.876 mg/L 3compartmentss NA 50% Human Human -DTXSID6044272 Css NA 35.77 mg/L 3compartmentss NA 95% Human Human -DTXSID6044272 Css NA 5.104 mg/L PBTK NA 50% Human Human -DTXSID6044272 Css NA 21.5 mg/L PBTK NA 95% Human Human -DTXSID6044272 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044272 Fup NA 0.1273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044272 Vd NA 0.6263 L/kg 1compartment NA NA Rat Human -DTXSID6044272 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6044272 TK.Half.Life NA 11.02 hours 1compartment NA NA Rat Human -DTXSID6044272 Css NA 2.194 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044272 Css NA 8.402 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044272 Css NA 1.336 mg/L PBTK NA 50% Rat Human -DTXSID6044272 Css NA 4.703 mg/L PBTK NA 95% Rat Human -DTXSID6044303 Clint NA 1.031 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044303 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044303 Vd NA 11.35 L/kg 1compartment NA NA Human Human -DTXSID6044303 Days.Css NA 1908 Days PBTK NA NA Human Human -DTXSID6044303 TK.Half.Life NA 7018 hours 1compartment NA NA Human Human -DTXSID6044303 Css NA 39.83 mg/L 3compartmentss NA 50% Human Human -DTXSID6044303 Css NA 224.3 mg/L 3compartmentss NA 95% Human Human -DTXSID6044303 Css NA 51.41 mg/L PBTK NA 50% Human Human -DTXSID6044303 Css NA 277.6 mg/L PBTK NA 95% Human Human -DTXSID6044303 Clint NA 1.031 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044303 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044303 Vd NA 8.986 L/kg 1compartment NA NA Rat Human -DTXSID6044303 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID6044303 TK.Half.Life NA 983.3 hours 1compartment NA NA Rat Human -DTXSID6044303 Css NA 21.22 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044303 Css NA 86.53 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044303 Css NA 27.85 mg/L PBTK NA 50% Rat Human -DTXSID6044303 Css NA 113 mg/L PBTK NA 95% Rat Human -DTXSID6044307 Clint NA 4.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044307 Fup NA 0.2453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044307 Vd NA 2.659 L/kg 1compartment NA NA Human Human -DTXSID6044307 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6044307 TK.Half.Life NA 27.11 hours 1compartment NA NA Human Human -DTXSID6044307 Css NA 1.134 mg/L 3compartmentss NA 50% Human Human -DTXSID6044307 Css NA 5.271 mg/L 3compartmentss NA 95% Human Human -DTXSID6044307 Css NA 0.8326 mg/L PBTK NA 50% Human Human -DTXSID6044307 Css NA 3.688 mg/L PBTK NA 95% Human Human -DTXSID6044307 Clint NA 4.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044307 Fup NA 0.2453 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044307 Vd NA 2.026 L/kg 1compartment NA NA Rat Human -DTXSID6044307 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6044307 TK.Half.Life NA 5.955 hours 1compartment NA NA Rat Human -DTXSID6044307 Css NA 0.5665 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044307 Css NA 1.941 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044307 Css NA 0.4021 mg/L PBTK NA 50% Rat Human -DTXSID6044307 Css NA 1.273 mg/L PBTK NA 95% Rat Human -DTXSID6044355 Clint NA 30.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044355 Fup NA 0.1806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044355 Vd NA 2.345 L/kg 1compartment NA NA Human Human +DTXSID6044226 TK.Half.Life NA 2.388 hours 1compartment NA NA Rat Human +DTXSID6044226 Css NA 0.1916 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044226 Css NA 1.541 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044226 Css NA 0.1104 mg/L PBTK NA 50% Rat Human +DTXSID6044226 Css NA 0.8764 mg/L PBTK NA 95% Rat Human +DTXSID6044272 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044272 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044272 Vd NA 0.697 L/kg 1compartment NA NA Human Human +DTXSID6044272 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044272 TK.Half.Life NA 1.17 hours 1compartment NA NA Human Human +DTXSID6044272 Css NA 0.09572 mg/L 3compartmentss NA 50% Human Human +DTXSID6044272 Css NA 0.707 mg/L 3compartmentss NA 95% Human Human +DTXSID6044272 Css NA 0.06448 mg/L PBTK NA 50% Human Human +DTXSID6044272 Css NA 0.4592 mg/L PBTK NA 95% Human Human +DTXSID6044272 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044272 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044272 Vd NA 0.5938 L/kg 1compartment NA NA Rat Human +DTXSID6044272 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6044272 TK.Half.Life NA 0.5428 hours 1compartment NA NA Rat Human +DTXSID6044272 Css NA 0.004592 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044272 Css NA 0.03691 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044272 Css NA 0.003018 mg/L PBTK NA 50% Rat Human +DTXSID6044272 Css NA 0.02291 mg/L PBTK NA 95% Rat Human +DTXSID6044278 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044278 Fup 0.18 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6044278 Vd NA 1.046 L/kg 1compartment NA NA Human Human +DTXSID6044278 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044278 TK.Half.Life NA 4.219 hours 1compartment NA NA Human Human +DTXSID6044278 Css NA 0.4172 mg/L 3compartmentss NA 50% Human Human +DTXSID6044278 Css NA 2.56 mg/L 3compartmentss NA 95% Human Human +DTXSID6044278 Css NA 0.288 mg/L PBTK NA 50% Human Human +DTXSID6044278 Css NA 1.65 mg/L PBTK NA 95% Human Human +DTXSID6044278 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044278 Fup 0.18 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6044278 Vd NA 0.8521 L/kg 1compartment NA NA Rat Human +DTXSID6044278 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6044278 TK.Half.Life NA 1.895 hours 1compartment NA NA Rat Human +DTXSID6044278 Css NA 0.05018 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044278 Css NA 0.2119 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044278 Css NA 0.03427 mg/L PBTK NA 50% Rat Human +DTXSID6044278 Css NA 0.1332 mg/L PBTK NA 95% Rat Human +DTXSID6044303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044303 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044303 Vd NA 2.892 L/kg 1compartment NA NA Human Human +DTXSID6044303 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID6044303 TK.Half.Life NA 49.58 hours 1compartment NA NA Human Human +DTXSID6044303 Css NA 1.941 mg/L 3compartmentss NA 50% Human Human +DTXSID6044303 Css NA 13.26 mg/L 3compartmentss NA 95% Human Human +DTXSID6044303 Css NA 1.315 mg/L PBTK NA 50% Human Human +DTXSID6044303 Css NA 8.678 mg/L PBTK NA 95% Human Human +DTXSID6044303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044303 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044303 Vd NA 2.164 L/kg 1compartment NA NA Rat Human +DTXSID6044303 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6044303 TK.Half.Life NA 8.897 hours 1compartment NA NA Rat Human +DTXSID6044303 Css NA 0.09873 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044303 Css NA 0.7027 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044303 Css NA 0.06504 mg/L PBTK NA 50% Rat Human +DTXSID6044303 Css NA 0.4507 mg/L PBTK NA 95% Rat Human +DTXSID6044305 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044305 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044305 Vd NA 0.4439 L/kg 1compartment NA NA Human Human +DTXSID6044305 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044305 TK.Half.Life NA 0.7091 hours 1compartment NA NA Human Human +DTXSID6044305 Css NA 0.1105 mg/L 3compartmentss NA 50% Human Human +DTXSID6044305 Css NA 0.7843 mg/L 3compartmentss NA 95% Human Human +DTXSID6044305 Css NA 0.0783 mg/L PBTK NA 50% Human Human +DTXSID6044305 Css NA 0.5063 mg/L PBTK NA 95% Human Human +DTXSID6044305 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044305 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044305 Vd NA 0.4681 L/kg 1compartment NA NA Rat Human +DTXSID6044305 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6044305 TK.Half.Life NA 0.4075 hours 1compartment NA NA Rat Human +DTXSID6044305 Css NA 0.013 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044305 Css NA 0.07392 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044305 Css NA 0.009176 mg/L PBTK NA 50% Rat Human +DTXSID6044305 Css NA 0.04669 mg/L PBTK NA 95% Rat Human +DTXSID6044307 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044307 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044307 Vd NA 2.643 L/kg 1compartment NA NA Human Human +DTXSID6044307 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044307 TK.Half.Life NA 7.159 hours 1compartment NA NA Human Human +DTXSID6044307 Css NA 0.2297 mg/L 3compartmentss NA 50% Human Human +DTXSID6044307 Css NA 1.456 mg/L 3compartmentss NA 95% Human Human +DTXSID6044307 Css NA 0.1677 mg/L PBTK NA 50% Human Human +DTXSID6044307 Css NA 1.009 mg/L PBTK NA 95% Human Human +DTXSID6044307 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044307 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044307 Vd NA 2.013 L/kg 1compartment NA NA Rat Human +DTXSID6044307 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6044307 TK.Half.Life NA 1.849 hours 1compartment NA NA Rat Human +DTXSID6044307 Css NA 0.02899 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044307 Css NA 0.1468 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044307 Css NA 0.0211 mg/L PBTK NA 50% Rat Human +DTXSID6044307 Css NA 0.1034 mg/L PBTK NA 95% Rat Human +DTXSID6044309 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044309 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044309 Vd NA 1.824 L/kg 1compartment NA NA Human Human +DTXSID6044309 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044309 TK.Half.Life NA 9.607 hours 1compartment NA NA Human Human +DTXSID6044309 Css NA 0.5608 mg/L 3compartmentss NA 50% Human Human +DTXSID6044309 Css NA 3.063 mg/L 3compartmentss NA 95% Human Human +DTXSID6044309 Css NA 0.395 mg/L PBTK NA 50% Human Human +DTXSID6044309 Css NA 2.037 mg/L PBTK NA 95% Human Human +DTXSID6044309 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044309 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044309 Vd NA 1.408 L/kg 1compartment NA NA Rat Human +DTXSID6044309 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6044309 TK.Half.Life NA 3.365 hours 1compartment NA NA Rat Human +DTXSID6044309 Css NA 0.06701 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044309 Css NA 0.2702 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044309 Css NA 0.04726 mg/L PBTK NA 50% Rat Human +DTXSID6044309 Css NA 0.1767 mg/L PBTK NA 95% Rat Human +DTXSID6044353 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044353 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044353 Vd NA 1.42 L/kg 1compartment NA NA Human Human +DTXSID6044353 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044353 TK.Half.Life NA 2.47 hours 1compartment NA NA Human Human +DTXSID6044353 Css NA 0.1182 mg/L 3compartmentss NA 50% Human Human +DTXSID6044353 Css NA 0.8075 mg/L 3compartmentss NA 95% Human Human +DTXSID6044353 Css NA 0.085 mg/L PBTK NA 50% Human Human +DTXSID6044353 Css NA 0.5383 mg/L PBTK NA 95% Human Human +DTXSID6044353 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044353 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044353 Vd NA 1.126 L/kg 1compartment NA NA Rat Human +DTXSID6044353 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6044353 TK.Half.Life NA 0.9857 hours 1compartment NA NA Rat Human +DTXSID6044353 Css NA 0.015 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044353 Css NA 0.07743 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044353 Css NA 0.01064 mg/L PBTK NA 50% Rat Human +DTXSID6044353 Css NA 0.05151 mg/L PBTK NA 95% Rat Human +DTXSID6044355 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044355 Fup 0.288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044355 Vd NA 3.037 L/kg 1compartment NA NA Human Human DTXSID6044355 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044355 TK.Half.Life NA 3.11 hours 1compartment NA NA Human Human -DTXSID6044355 Css NA 0.0736 mg/L 3compartmentss NA 50% Human Human -DTXSID6044355 Css NA 0.5196 mg/L 3compartmentss NA 95% Human Human -DTXSID6044355 Css NA 0.06358 mg/L PBTK NA 50% Human Human -DTXSID6044355 Css NA 0.4076 mg/L PBTK NA 95% Human Human -DTXSID6044355 Clint NA 30.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044355 Fup NA 0.1806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044355 Vd NA 2.191 L/kg 1compartment NA NA Rat Human +DTXSID6044355 TK.Half.Life NA 3.652 hours 1compartment NA NA Human Human +DTXSID6044355 Css NA 0.05844 mg/L 3compartmentss NA 50% Human Human +DTXSID6044355 Css NA 0.4703 mg/L 3compartmentss NA 95% Human Human +DTXSID6044355 Css NA 0.05707 mg/L PBTK NA 50% Human Human +DTXSID6044355 Css NA 0.3924 mg/L PBTK NA 95% Human Human +DTXSID6044355 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044355 Fup 0.288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044355 Vd NA 2.861 L/kg 1compartment NA NA Rat Human DTXSID6044355 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044355 TK.Half.Life NA 1.509 hours 1compartment NA NA Rat Human -DTXSID6044355 Css NA 0.03926 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044355 Css NA 0.2168 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044355 Css NA 0.03288 mg/L PBTK NA 50% Rat Human -DTXSID6044355 Css NA 0.1591 mg/L PBTK NA 95% Rat Human +DTXSID6044355 TK.Half.Life NA 1.715 hours 1compartment NA NA Rat Human +DTXSID6044355 Css NA 0.007174 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044355 Css NA 0.04353 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044355 Css NA 0.007196 mg/L PBTK NA 50% Rat Human +DTXSID6044355 Css NA 0.03667 mg/L PBTK NA 95% Rat Human DTXSID6044357 Clint 90.03 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID6044357 Fup 0.9392 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID6044357 Vd NA 1.39 L/kg 1compartment NA NA Human Human DTXSID6044357 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6044357 TK.Half.Life NA 0.7739 hours 1compartment NA NA Human Human -DTXSID6044357 Css NA 0.005616 mg/L 3compartmentss NA 50% Human Human -DTXSID6044357 Css NA 0.04844 mg/L 3compartmentss NA 95% Human Human -DTXSID6044357 Css NA 0.005117 mg/L PBTK NA 50% Human Human -DTXSID6044357 Css NA 0.03865 mg/L PBTK NA 95% Human Human +DTXSID6044357 Css NA 0.004139 mg/L 3compartmentss NA 50% Human Human +DTXSID6044357 Css NA 0.04724 mg/L 3compartmentss NA 95% Human Human +DTXSID6044357 Css NA 0.003812 mg/L PBTK NA 50% Human Human +DTXSID6044357 Css NA 0.03807 mg/L PBTK NA 95% Human Human DTXSID6044357 Clint 90.03 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID6044357 Fup 0.9392 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID6044357 Vd NA 1.288 L/kg 1compartment NA NA Rat Human DTXSID6044357 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6044357 TK.Half.Life NA 0.3177 hours 1compartment NA NA Rat Human -DTXSID6044357 Css NA 0.002884 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044357 Css NA 0.02223 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044357 Css NA 0.00265 mg/L PBTK NA 50% Rat Human -DTXSID6044357 Css NA 0.01777 mg/L PBTK NA 95% Rat Human -DTXSID6044359 Clint NA 18.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044359 Fup NA 0.0322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044359 Vd NA 3.123 L/kg 1compartment NA NA Human Human -DTXSID6044359 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID6044359 TK.Half.Life NA 103.9 hours 1compartment NA NA Human Human -DTXSID6044359 Css NA 4.038 mg/L 3compartmentss NA 50% Human Human -DTXSID6044359 Css NA 23.96 mg/L 3compartmentss NA 95% Human Human -DTXSID6044359 Css NA 2.804 mg/L PBTK NA 50% Human Human -DTXSID6044359 Css NA 16.25 mg/L PBTK NA 95% Human Human -DTXSID6044359 Clint NA 18.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044359 Fup NA 0.0322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044359 Vd NA 2.341 L/kg 1compartment NA NA Rat Human -DTXSID6044359 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID6044359 TK.Half.Life NA 13.81 hours 1compartment NA NA Rat Human -DTXSID6044359 Css NA 2.277 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044359 Css NA 10.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044359 Css NA 1.516 mg/L PBTK NA 50% Rat Human -DTXSID6044359 Css NA 6.7 mg/L PBTK NA 95% Rat Human -DTXSID6044430 Clint NA 6.856 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044430 Fup NA 0.0861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044430 Vd NA 2.051 L/kg 1compartment NA NA Human Human -DTXSID6044430 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6044430 TK.Half.Life NA 19.96 hours 1compartment NA NA Human Human -DTXSID6044430 Css NA 1.34 mg/L 3compartmentss NA 50% Human Human -DTXSID6044430 Css NA 8.098 mg/L 3compartmentss NA 95% Human Human -DTXSID6044430 Css NA 0.9036 mg/L PBTK NA 50% Human Human -DTXSID6044430 Css NA 5.181 mg/L PBTK NA 95% Human Human -DTXSID6044430 Clint NA 6.856 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044430 Fup NA 0.0861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044430 Vd NA 1.548 L/kg 1compartment NA NA Rat Human -DTXSID6044430 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6044430 TK.Half.Life NA 6.211 hours 1compartment NA NA Rat Human -DTXSID6044430 Css NA 0.7134 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044430 Css NA 3.252 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044430 Css NA 0.4544 mg/L PBTK NA 50% Rat Human -DTXSID6044430 Css NA 1.936 mg/L PBTK NA 95% Rat Human -DTXSID6044436 Clint NA 0.001135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044436 Fup NA 0.594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044436 Vd NA 0.4201 L/kg 1compartment NA NA Human Human +DTXSID6044357 Css NA 0.0005254 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044357 Css NA 0.004843 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044357 Css NA 0.0005028 mg/L PBTK NA 50% Rat Human +DTXSID6044357 Css NA 0.003835 mg/L PBTK NA 95% Rat Human +DTXSID6044359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044359 Fup 0.0153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044359 Vd NA 3.109 L/kg 1compartment NA NA Human Human +DTXSID6044359 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID6044359 TK.Half.Life NA 89.83 hours 1compartment NA NA Human Human +DTXSID6044359 Css NA 3.413 mg/L 3compartmentss NA 50% Human Human +DTXSID6044359 Css NA 20.92 mg/L 3compartmentss NA 95% Human Human +DTXSID6044359 Css NA 2.363 mg/L PBTK NA 50% Human Human +DTXSID6044359 Css NA 13.97 mg/L PBTK NA 95% Human Human +DTXSID6044359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044359 Fup 0.0153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044359 Vd NA 2.328 L/kg 1compartment NA NA Rat Human +DTXSID6044359 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID6044359 TK.Half.Life NA 12.25 hours 1compartment NA NA Rat Human +DTXSID6044359 Css NA 0.4443 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044359 Css NA 2.254 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044359 Css NA 0.3038 mg/L PBTK NA 50% Rat Human +DTXSID6044359 Css NA 1.543 mg/L PBTK NA 95% Rat Human +DTXSID6044430 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044430 Fup 0.0339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044430 Vd NA 1.422 L/kg 1compartment NA NA Human Human +DTXSID6044430 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044430 TK.Half.Life NA 8.777 hours 1compartment NA NA Human Human +DTXSID6044430 Css NA 0.9122 mg/L 3compartmentss NA 50% Human Human +DTXSID6044430 Css NA 7.355 mg/L 3compartmentss NA 95% Human Human +DTXSID6044430 Css NA 0.5756 mg/L PBTK NA 50% Human Human +DTXSID6044430 Css NA 4.417 mg/L PBTK NA 95% Human Human +DTXSID6044430 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044430 Fup 0.0339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044430 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID6044430 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6044430 TK.Half.Life NA 3.459 hours 1compartment NA NA Rat Human +DTXSID6044430 Css NA 0.1193 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044430 Css NA 0.756 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044430 Css NA 0.07275 mg/L PBTK NA 50% Rat Human +DTXSID6044430 Css NA 0.445 mg/L PBTK NA 95% Rat Human +DTXSID6044436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044436 Fup 0.701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044436 Vd NA 0.7673 L/kg 1compartment NA NA Human Human DTXSID6044436 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044436 TK.Half.Life NA 4.566 hours 1compartment NA NA Human Human -DTXSID6044436 Css NA 1.368 mg/L 3compartmentss NA 50% Human Human -DTXSID6044436 Css NA 8.46 mg/L 3compartmentss NA 95% Human Human -DTXSID6044436 Css NA 0.9846 mg/L PBTK NA 50% Human Human -DTXSID6044436 Css NA 5.184 mg/L PBTK NA 95% Human Human -DTXSID6044436 Clint NA 0.001135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044436 Fup NA 0.594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044436 Vd NA 0.4336 L/kg 1compartment NA NA Rat Human +DTXSID6044436 TK.Half.Life NA 7.121 hours 1compartment NA NA Human Human +DTXSID6044436 Css NA 1.043 mg/L 3compartmentss NA 50% Human Human +DTXSID6044436 Css NA 7.08 mg/L 3compartmentss NA 95% Human Human +DTXSID6044436 Css NA 0.858 mg/L PBTK NA 50% Human Human +DTXSID6044436 Css NA 4.4 mg/L PBTK NA 95% Human Human +DTXSID6044436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044436 Fup 0.701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044436 Vd NA 0.7748 L/kg 1compartment NA NA Rat Human DTXSID6044436 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044436 TK.Half.Life NA 1.608 hours 1compartment NA NA Rat Human -DTXSID6044436 Css NA 0.3647 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044436 Css NA 2.192 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044436 Css NA 0.2504 mg/L PBTK NA 50% Rat Human -DTXSID6044436 Css NA 1.248 mg/L PBTK NA 95% Rat Human -DTXSID6044438 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044438 Fup NA 0.8829 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044438 Vd NA 0.8096 L/kg 1compartment NA NA Human Human +DTXSID6044436 TK.Half.Life NA 2.44 hours 1compartment NA NA Rat Human +DTXSID6044436 Css NA 0.06247 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044436 Css NA 0.4043 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044436 Css NA 0.05151 mg/L PBTK NA 50% Rat Human +DTXSID6044436 Css NA 0.2485 mg/L PBTK NA 95% Rat Human +DTXSID6044438 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044438 Fup 0.727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044438 Vd NA 0.7203 L/kg 1compartment NA NA Human Human DTXSID6044438 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044438 TK.Half.Life NA 5.95 hours 1compartment NA NA Human Human -DTXSID6044438 Css NA 0.9375 mg/L 3compartmentss NA 50% Human Human -DTXSID6044438 Css NA 5.214 mg/L 3compartmentss NA 95% Human Human -DTXSID6044438 Css NA 0.7831 mg/L PBTK NA 50% Human Human -DTXSID6044438 Css NA 3.466 mg/L PBTK NA 95% Human Human -DTXSID6044438 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044438 Fup NA 0.8829 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044438 Vd NA 0.8317 L/kg 1compartment NA NA Rat Human +DTXSID6044438 TK.Half.Life NA 6.424 hours 1compartment NA NA Human Human +DTXSID6044438 Css NA 0.8968 mg/L 3compartmentss NA 50% Human Human +DTXSID6044438 Css NA 5.857 mg/L 3compartmentss NA 95% Human Human +DTXSID6044438 Css NA 0.731 mg/L PBTK NA 50% Human Human +DTXSID6044438 Css NA 3.8 mg/L PBTK NA 95% Human Human +DTXSID6044438 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044438 Fup 0.727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044438 Vd NA 0.7391 L/kg 1compartment NA NA Rat Human DTXSID6044438 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044438 TK.Half.Life NA 2.078 hours 1compartment NA NA Rat Human -DTXSID6044438 Css NA 0.2338 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044438 Css NA 1.354 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044438 Css NA 0.1916 mg/L PBTK NA 50% Rat Human -DTXSID6044438 Css NA 0.8197 mg/L PBTK NA 95% Rat Human -DTXSID6044480 Clint NA 0.9552 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044480 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044480 Vd NA 0.8858 L/kg 1compartment NA NA Human Human +DTXSID6044438 TK.Half.Life NA 2.243 hours 1compartment NA NA Rat Human +DTXSID6044438 Css NA 0.0173 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044438 Css NA 0.1368 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044438 Css NA 0.01358 mg/L PBTK NA 50% Rat Human +DTXSID6044438 Css NA 0.08853 mg/L PBTK NA 95% Rat Human +DTXSID6044480 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044480 Fup 0.75 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044480 Vd NA 0.8555 L/kg 1compartment NA NA Human Human DTXSID6044480 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044480 TK.Half.Life NA 2.413 hours 1compartment NA NA Human Human -DTXSID6044480 Css NA 0.3134 mg/L 3compartmentss NA 50% Human Human -DTXSID6044480 Css NA 2.167 mg/L 3compartmentss NA 95% Human Human -DTXSID6044480 Css NA 0.2704 mg/L PBTK NA 50% Human Human -DTXSID6044480 Css NA 1.475 mg/L PBTK NA 95% Human Human -DTXSID6044480 Clint NA 0.9552 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044480 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044480 Vd NA 0.9086 L/kg 1compartment NA NA Rat Human +DTXSID6044480 TK.Half.Life NA 7.453 hours 1compartment NA NA Human Human +DTXSID6044480 Css NA 0.8576 mg/L 3compartmentss NA 50% Human Human +DTXSID6044480 Css NA 5.54 mg/L 3compartmentss NA 95% Human Human +DTXSID6044480 Css NA 0.7292 mg/L PBTK NA 50% Human Human +DTXSID6044480 Css NA 3.561 mg/L PBTK NA 95% Human Human +DTXSID6044480 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044480 Fup 0.75 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044480 Vd NA 0.8534 L/kg 1compartment NA NA Rat Human DTXSID6044480 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044480 TK.Half.Life NA 1.177 hours 1compartment NA NA Rat Human -DTXSID6044480 Css NA 0.1166 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044480 Css NA 0.7476 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044480 Css NA 0.09948 mg/L PBTK NA 50% Rat Human -DTXSID6044480 Css NA 0.4563 mg/L PBTK NA 95% Rat Human -DTXSID6044484 Clint NA 103.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044484 Fup NA 0.3793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044484 Vd NA 3.887 L/kg 1compartment NA NA Human Human -DTXSID6044484 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044484 TK.Half.Life NA 1.69 hours 1compartment NA NA Human Human -DTXSID6044484 Css NA 0.004624 mg/L 3compartmentss NA 50% Human Human -DTXSID6044484 Css NA 0.04741 mg/L 3compartmentss NA 95% Human Human -DTXSID6044484 Css NA 0.006584 mg/L PBTK NA 50% Human Human -DTXSID6044484 Css NA 0.04795 mg/L PBTK NA 95% Human Human -DTXSID6044484 Clint NA 103.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044484 Fup NA 0.3793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044484 Vd NA 3.883 L/kg 1compartment NA NA Rat Human -DTXSID6044484 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044484 TK.Half.Life NA 0.8035 hours 1compartment NA NA Rat Human -DTXSID6044484 Css NA 0.00244 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044484 Css NA 0.01998 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044484 Css NA 0.003509 mg/L PBTK NA 50% Rat Human -DTXSID6044484 Css NA 0.02077 mg/L PBTK NA 95% Rat Human +DTXSID6044480 TK.Half.Life NA 2.515 hours 1compartment NA NA Rat Human +DTXSID6044480 Css NA 0.01588 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044480 Css NA 0.1336 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044480 Css NA 0.01293 mg/L PBTK NA 50% Rat Human +DTXSID6044480 Css NA 0.08658 mg/L PBTK NA 95% Rat Human DTXSID6044486 Clint NA 13.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6044486 Fup NA 0.6245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044486 Vd NA 1.052 L/kg 1compartment NA NA Human Human +DTXSID6044486 Vd NA 0.9887 L/kg 1compartment NA NA Human Human DTXSID6044486 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044486 TK.Half.Life NA 1.064 hours 1compartment NA NA Human Human -DTXSID6044486 Css NA 0.05224 mg/L 3compartmentss NA 50% Human Human -DTXSID6044486 Css NA 0.5276 mg/L 3compartmentss NA 95% Human Human -DTXSID6044486 Css NA 0.04376 mg/L PBTK NA 50% Human Human -DTXSID6044486 Css NA 0.3632 mg/L PBTK NA 95% Human Human +DTXSID6044486 TK.Half.Life NA 1.001 hours 1compartment NA NA Human Human +DTXSID6044486 Css NA 0.04067 mg/L 3compartmentss NA 50% Human Human +DTXSID6044486 Css NA 0.4376 mg/L 3compartmentss NA 95% Human Human +DTXSID6044486 Css NA 0.03398 mg/L PBTK NA 50% Human Human +DTXSID6044486 Css NA 0.3015 mg/L PBTK NA 95% Human Human DTXSID6044486 Clint NA 13.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6044486 Fup NA 0.6245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044486 Vd NA 0.9787 L/kg 1compartment NA NA Rat Human +DTXSID6044486 Vd NA 0.9323 L/kg 1compartment NA NA Rat Human DTXSID6044486 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044486 TK.Half.Life NA 0.5041 hours 1compartment NA NA Rat Human -DTXSID6044486 Css NA 0.02666 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044486 Css NA 0.2298 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044486 Css NA 0.02192 mg/L PBTK NA 50% Rat Human -DTXSID6044486 Css NA 0.1458 mg/L PBTK NA 95% Rat Human -DTXSID6044488 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044488 Fup NA 0.8995 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044488 Vd NA 1.663 L/kg 1compartment NA NA Human Human +DTXSID6044486 TK.Half.Life NA 0.481 hours 1compartment NA NA Rat Human +DTXSID6044486 Css NA 0.00147 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044486 Css NA 0.01832 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044486 Css NA 0.001205 mg/L PBTK NA 50% Rat Human +DTXSID6044486 Css NA 0.01231 mg/L PBTK NA 95% Rat Human +DTXSID6044488 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044488 Fup 0.762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044488 Vd NA 1.493 L/kg 1compartment NA NA Human Human DTXSID6044488 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6044488 TK.Half.Life NA 12.02 hours 1compartment NA NA Human Human -DTXSID6044488 Css NA 0.7627 mg/L 3compartmentss NA 50% Human Human -DTXSID6044488 Css NA 3.143 mg/L 3compartmentss NA 95% Human Human -DTXSID6044488 Css NA 0.736 mg/L PBTK NA 50% Human Human -DTXSID6044488 Css NA 2.363 mg/L PBTK NA 95% Human Human -DTXSID6044488 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044488 Fup NA 0.8995 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044488 Vd NA 1.684 L/kg 1compartment NA NA Rat Human +DTXSID6044488 TK.Half.Life NA 12.73 hours 1compartment NA NA Human Human +DTXSID6044488 Css NA 0.8774 mg/L 3compartmentss NA 50% Human Human +DTXSID6044488 Css NA 5.991 mg/L 3compartmentss NA 95% Human Human +DTXSID6044488 Css NA 0.8173 mg/L PBTK NA 50% Human Human +DTXSID6044488 Css NA 4.017 mg/L PBTK NA 95% Human Human +DTXSID6044488 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044488 Fup 0.762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044488 Vd NA 1.509 L/kg 1compartment NA NA Rat Human DTXSID6044488 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044488 TK.Half.Life NA 4.133 hours 1compartment NA NA Rat Human -DTXSID6044488 Css NA 0.1952 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044488 Css NA 0.7632 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044488 Css NA 0.1859 mg/L PBTK NA 50% Rat Human -DTXSID6044488 Css NA 0.5238 mg/L PBTK NA 95% Rat Human -DTXSID6044511 Clint NA 2.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044511 Fup NA 0.1697 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044511 Vd NA 1.484 L/kg 1compartment NA NA Human Human -DTXSID6044511 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6044511 TK.Half.Life NA 14.6 hours 1compartment NA NA Human Human -DTXSID6044511 Css NA 1.198 mg/L 3compartmentss NA 50% Human Human -DTXSID6044511 Css NA 5.65 mg/L 3compartmentss NA 95% Human Human -DTXSID6044511 Css NA 0.84 mg/L PBTK NA 50% Human Human -DTXSID6044511 Css NA 3.647 mg/L PBTK NA 95% Human Human -DTXSID6044511 Clint NA 2.385 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044511 Fup NA 0.1697 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044511 Vd NA 1.161 L/kg 1compartment NA NA Rat Human +DTXSID6044488 TK.Half.Life NA 4.37 hours 1compartment NA NA Rat Human +DTXSID6044488 Css NA 0.05172 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044488 Css NA 0.3713 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044488 Css NA 0.04862 mg/L PBTK NA 50% Rat Human +DTXSID6044488 Css NA 0.2366 mg/L PBTK NA 95% Rat Human +DTXSID6044511 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044511 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044511 Vd NA 2.868 L/kg 1compartment NA NA Human Human +DTXSID6044511 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044511 TK.Half.Life NA 9.452 hours 1compartment NA NA Human Human +DTXSID6044511 Css NA 0.295 mg/L 3compartmentss NA 50% Human Human +DTXSID6044511 Css NA 1.832 mg/L 3compartmentss NA 95% Human Human +DTXSID6044511 Css NA 0.2144 mg/L PBTK NA 50% Human Human +DTXSID6044511 Css NA 1.284 mg/L PBTK NA 95% Human Human +DTXSID6044511 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044511 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044511 Vd NA 2.177 L/kg 1compartment NA NA Rat Human DTXSID6044511 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044511 TK.Half.Life NA 5.336 hours 1compartment NA NA Rat Human -DTXSID6044511 Css NA 0.5575 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044511 Css NA 1.975 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044511 Css NA 0.3739 mg/L PBTK NA 50% Rat Human -DTXSID6044511 Css NA 1.191 mg/L PBTK NA 95% Rat Human -DTXSID6044513 Clint NA 44.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044513 Fup NA 0.3581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044513 Vd NA 2.611 L/kg 1compartment NA NA Human Human +DTXSID6044511 TK.Half.Life NA 2.078 hours 1compartment NA NA Rat Human +DTXSID6044511 Css NA 0.03724 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044511 Css NA 0.1855 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044511 Css NA 0.0271 mg/L PBTK NA 50% Rat Human +DTXSID6044511 Css NA 0.129 mg/L PBTK NA 95% Rat Human +DTXSID6044513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044513 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044513 Vd NA 1.318 L/kg 1compartment NA NA Human Human DTXSID6044513 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044513 TK.Half.Life NA 3.454 hours 1compartment NA NA Human Human -DTXSID6044513 Css NA 0.07156 mg/L 3compartmentss NA 50% Human Human -DTXSID6044513 Css NA 0.4767 mg/L 3compartmentss NA 95% Human Human -DTXSID6044513 Css NA 0.05438 mg/L PBTK NA 50% Human Human -DTXSID6044513 Css NA 0.3458 mg/L PBTK NA 95% Human Human -DTXSID6044513 Clint NA 44.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044513 Fup NA 0.3581 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044513 Vd NA 2.011 L/kg 1compartment NA NA Rat Human +DTXSID6044513 TK.Half.Life NA 1.303 hours 1compartment NA NA Human Human +DTXSID6044513 Css NA 0.03864 mg/L 3compartmentss NA 50% Human Human +DTXSID6044513 Css NA 0.3598 mg/L 3compartmentss NA 95% Human Human +DTXSID6044513 Css NA 0.032 mg/L PBTK NA 50% Human Human +DTXSID6044513 Css NA 0.2609 mg/L PBTK NA 95% Human Human +DTXSID6044513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044513 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044513 Vd NA 1.14 L/kg 1compartment NA NA Rat Human DTXSID6044513 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044513 TK.Half.Life NA 1.012 hours 1compartment NA NA Rat Human -DTXSID6044513 Css NA 0.03903 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044513 Css NA 0.2078 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044513 Css NA 0.02868 mg/L PBTK NA 50% Rat Human -DTXSID6044513 Css NA 0.1437 mg/L PBTK NA 95% Rat Human -DTXSID6044515 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044515 Fup NA 0.2796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044515 Vd NA 0.8586 L/kg 1compartment NA NA Human Human +DTXSID6044513 TK.Half.Life NA 0.5519 hours 1compartment NA NA Rat Human +DTXSID6044513 Css NA 0.004855 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044513 Css NA 0.03456 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044513 Css NA 0.004034 mg/L PBTK NA 50% Rat Human +DTXSID6044513 Css NA 0.02402 mg/L PBTK NA 95% Rat Human +DTXSID6044515 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044515 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044515 Vd NA 1.239 L/kg 1compartment NA NA Human Human DTXSID6044515 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044515 TK.Half.Life NA 3.047 hours 1compartment NA NA Human Human -DTXSID6044515 Css NA 0.3494 mg/L 3compartmentss NA 50% Human Human -DTXSID6044515 Css NA 2.065 mg/L 3compartmentss NA 95% Human Human -DTXSID6044515 Css NA 0.2538 mg/L PBTK NA 50% Human Human -DTXSID6044515 Css NA 1.382 mg/L PBTK NA 95% Human Human -DTXSID6044515 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044515 Fup NA 0.2796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044515 Vd NA 0.7522 L/kg 1compartment NA NA Rat Human +DTXSID6044515 TK.Half.Life NA 1.371 hours 1compartment NA NA Human Human +DTXSID6044515 Css NA 0.04853 mg/L 3compartmentss NA 50% Human Human +DTXSID6044515 Css NA 0.383 mg/L 3compartmentss NA 95% Human Human +DTXSID6044515 Css NA 0.03842 mg/L PBTK NA 50% Human Human +DTXSID6044515 Css NA 0.2736 mg/L PBTK NA 95% Human Human +DTXSID6044515 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044515 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044515 Vd NA 1.06 L/kg 1compartment NA NA Rat Human DTXSID6044515 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044515 TK.Half.Life NA 1.48 hours 1compartment NA NA Rat Human -DTXSID6044515 Css NA 0.175 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044515 Css NA 0.7338 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044515 Css NA 0.1214 mg/L PBTK NA 50% Rat Human -DTXSID6044515 Css NA 0.4494 mg/L PBTK NA 95% Rat Human -DTXSID6044517 Clint NA 4.024 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044517 Fup NA 0.2902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044517 Vd NA 0.9702 L/kg 1compartment NA NA Human Human +DTXSID6044515 TK.Half.Life NA 0.5844 hours 1compartment NA NA Rat Human +DTXSID6044515 Css NA 0.006088 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044515 Css NA 0.03705 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044515 Css NA 0.004818 mg/L PBTK NA 50% Rat Human +DTXSID6044515 Css NA 0.0258 mg/L PBTK NA 95% Rat Human +DTXSID6044517 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044517 Fup 0.354 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044517 Vd NA 1.241 L/kg 1compartment NA NA Human Human DTXSID6044517 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044517 TK.Half.Life NA 3.499 hours 1compartment NA NA Human Human -DTXSID6044517 Css NA 0.3568 mg/L 3compartmentss NA 50% Human Human -DTXSID6044517 Css NA 2.008 mg/L 3compartmentss NA 95% Human Human -DTXSID6044517 Css NA 0.2646 mg/L PBTK NA 50% Human Human -DTXSID6044517 Css NA 1.322 mg/L PBTK NA 95% Human Human -DTXSID6044517 Clint NA 4.024 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044517 Fup NA 0.2902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044517 Vd NA 0.8348 L/kg 1compartment NA NA Rat Human +DTXSID6044517 TK.Half.Life NA 1.5 hours 1compartment NA NA Human Human +DTXSID6044517 Css NA 0.05854 mg/L 3compartmentss NA 50% Human Human +DTXSID6044517 Css NA 0.466 mg/L 3compartmentss NA 95% Human Human +DTXSID6044517 Css NA 0.04522 mg/L PBTK NA 50% Human Human +DTXSID6044517 Css NA 0.3231 mg/L PBTK NA 95% Human Human +DTXSID6044517 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044517 Fup 0.354 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044517 Vd NA 1.046 L/kg 1compartment NA NA Rat Human DTXSID6044517 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044517 TK.Half.Life NA 1.641 hours 1compartment NA NA Rat Human -DTXSID6044517 Css NA 0.1754 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044517 Css NA 0.7398 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044517 Css NA 0.1242 mg/L PBTK NA 50% Rat Human -DTXSID6044517 Css NA 0.4552 mg/L PBTK NA 95% Rat Human -DTXSID6044519 Clint NA 3.502 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044519 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044519 Vd NA 2.986 L/kg 1compartment NA NA Human Human -DTXSID6044519 Days.Css NA 57 Days PBTK NA NA Human Human -DTXSID6044519 TK.Half.Life NA 267.8 hours 1compartment NA NA Human Human -DTXSID6044519 Css NA 11.71 mg/L 3compartmentss NA 50% Human Human -DTXSID6044519 Css NA 64.35 mg/L 3compartmentss NA 95% Human Human -DTXSID6044519 Css NA 8.052 mg/L PBTK NA 50% Human Human -DTXSID6044519 Css NA 42.7 mg/L PBTK NA 95% Human Human -DTXSID6044519 Clint NA 3.502 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044519 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044519 Vd NA 2.237 L/kg 1compartment NA NA Rat Human -DTXSID6044519 Days.Css NA 30 Days PBTK NA NA Rat Human -DTXSID6044519 TK.Half.Life NA 40.53 hours 1compartment NA NA Rat Human -DTXSID6044519 Css NA 6.278 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044519 Css NA 26.96 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044519 Css NA 4.13 mg/L PBTK NA 50% Rat Human -DTXSID6044519 Css NA 16.91 mg/L PBTK NA 95% Rat Human -DTXSID6044561 Clint NA 66.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044561 Fup NA 0.2033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044561 Vd NA 3.242 L/kg 1compartment NA NA Human Human -DTXSID6044561 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044561 TK.Half.Life NA 2.855 hours 1compartment NA NA Human Human -DTXSID6044561 Css NA 0.02988 mg/L 3compartmentss NA 50% Human Human -DTXSID6044561 Css NA 0.2287 mg/L 3compartmentss NA 95% Human Human -DTXSID6044561 Css NA 0.0283 mg/L PBTK NA 50% Human Human -DTXSID6044561 Css NA 0.1892 mg/L PBTK NA 95% Human Human -DTXSID6044561 Clint NA 66.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044561 Fup NA 0.2033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044561 Vd NA 2.991 L/kg 1compartment NA NA Rat Human -DTXSID6044561 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044561 TK.Half.Life NA 1.218 hours 1compartment NA NA Rat Human -DTXSID6044561 Css NA 0.01609 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044561 Css NA 0.09617 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044561 Css NA 0.01512 mg/L PBTK NA 50% Rat Human -DTXSID6044561 Css NA 0.07736 mg/L PBTK NA 95% Rat Human -DTXSID6044563 Clint NA 9.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044563 Fup NA 0.2209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044563 Vd NA 1.205 L/kg 1compartment NA NA Human Human -DTXSID6044563 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044563 TK.Half.Life NA 3.074 hours 1compartment NA NA Human Human -DTXSID6044563 Css NA 0.2301 mg/L 3compartmentss NA 50% Human Human -DTXSID6044563 Css NA 1.418 mg/L 3compartmentss NA 95% Human Human -DTXSID6044563 Css NA 0.1647 mg/L PBTK NA 50% Human Human -DTXSID6044563 Css NA 0.9609 mg/L PBTK NA 95% Human Human -DTXSID6044563 Clint NA 9.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044563 Fup NA 0.2209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044563 Vd NA 0.9788 L/kg 1compartment NA NA Rat Human -DTXSID6044563 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044563 TK.Half.Life NA 1.334 hours 1compartment NA NA Rat Human -DTXSID6044563 Css NA 0.1202 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044563 Css NA 0.5459 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044563 Css NA 0.08238 mg/L PBTK NA 50% Rat Human -DTXSID6044563 Css NA 0.3449 mg/L PBTK NA 95% Rat Human -DTXSID6044565 Clint NA 56.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044565 Fup NA 0.8095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044565 Vd NA 2.381 L/kg 1compartment NA NA Human Human -DTXSID6044565 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044565 TK.Half.Life NA 1.229 hours 1compartment NA NA Human Human -DTXSID6044565 Css NA 0.008699 mg/L 3compartmentss NA 50% Human Human -DTXSID6044565 Css NA 0.1026 mg/L 3compartmentss NA 95% Human Human -DTXSID6044565 Css NA 0.009136 mg/L PBTK NA 50% Human Human -DTXSID6044565 Css NA 0.08372 mg/L PBTK NA 95% Human Human -DTXSID6044565 Clint NA 56.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044565 Fup NA 0.8095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044565 Vd NA 2.407 L/kg 1compartment NA NA Rat Human +DTXSID6044517 TK.Half.Life NA 0.6348 hours 1compartment NA NA Rat Human +DTXSID6044517 Css NA 0.007312 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044517 Css NA 0.04257 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044517 Css NA 0.005629 mg/L PBTK NA 50% Rat Human +DTXSID6044517 Css NA 0.02939 mg/L PBTK NA 95% Rat Human +DTXSID6044519 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044519 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044519 Vd NA 2.548 L/kg 1compartment NA NA Human Human +DTXSID6044519 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID6044519 TK.Half.Life NA 38.88 hours 1compartment NA NA Human Human +DTXSID6044519 Css NA 2.122 mg/L 3compartmentss NA 50% Human Human +DTXSID6044519 Css NA 16.01 mg/L 3compartmentss NA 95% Human Human +DTXSID6044519 Css NA 1.409 mg/L PBTK NA 50% Human Human +DTXSID6044519 Css NA 10.22 mg/L PBTK NA 95% Human Human +DTXSID6044519 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044519 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044519 Vd NA 1.899 L/kg 1compartment NA NA Rat Human +DTXSID6044519 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6044519 TK.Half.Life NA 9.251 hours 1compartment NA NA Rat Human +DTXSID6044519 Css NA 0.276 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044519 Css NA 1.693 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044519 Css NA 0.1794 mg/L PBTK NA 50% Rat Human +DTXSID6044519 Css NA 1.058 mg/L PBTK NA 95% Rat Human +DTXSID6044565 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044565 Fup 0.578 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044565 Vd NA 1.719 L/kg 1compartment NA NA Human Human +DTXSID6044565 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6044565 TK.Half.Life NA 19.24 hours 1compartment NA NA Human Human +DTXSID6044565 Css NA 1.028 mg/L 3compartmentss NA 50% Human Human +DTXSID6044565 Css NA 8.236 mg/L 3compartmentss NA 95% Human Human +DTXSID6044565 Css NA 0.991 mg/L PBTK NA 50% Human Human +DTXSID6044565 Css NA 5.427 mg/L PBTK NA 95% Human Human +DTXSID6044565 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044565 Fup 0.578 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044565 Vd NA 1.731 L/kg 1compartment NA NA Rat Human DTXSID6044565 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044565 TK.Half.Life NA 0.5805 hours 1compartment NA NA Rat Human -DTXSID6044565 Css NA 0.0044 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044565 Css NA 0.04741 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044565 Css NA 0.004722 mg/L PBTK NA 50% Rat Human -DTXSID6044565 Css NA 0.03785 mg/L PBTK NA 95% Rat Human -DTXSID6044642 Clint NA 28.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044642 Fup NA 0.0302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044642 Vd NA 0.226 L/kg 1compartment NA NA Human Human +DTXSID6044565 TK.Half.Life NA 6.601 hours 1compartment NA NA Rat Human +DTXSID6044565 Css NA 0.06128 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044565 Css NA 0.4561 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044565 Css NA 0.05947 mg/L PBTK NA 50% Rat Human +DTXSID6044565 Css NA 0.2933 mg/L PBTK NA 95% Rat Human +DTXSID6044642 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044642 Fup 0.0363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044642 Vd NA 0.4943 L/kg 1compartment NA NA Human Human DTXSID6044642 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044642 TK.Half.Life NA 1.211 hours 1compartment NA NA Human Human -DTXSID6044642 Css NA 0.8412 mg/L 3compartmentss NA 50% Human Human -DTXSID6044642 Css NA 8.074 mg/L 3compartmentss NA 95% Human Human -DTXSID6044642 Css NA 0.4986 mg/L PBTK NA 50% Human Human -DTXSID6044642 Css NA 4.774 mg/L PBTK NA 95% Human Human -DTXSID6044642 Clint NA 28.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044642 Fup NA 0.0302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044642 Vd NA 0.2139 L/kg 1compartment NA NA Rat Human +DTXSID6044642 TK.Half.Life NA 7.835 hours 1compartment NA NA Human Human +DTXSID6044642 Css NA 2.764 mg/L 3compartmentss NA 50% Human Human +DTXSID6044642 Css NA 19.36 mg/L 3compartmentss NA 95% Human Human +DTXSID6044642 Css NA 1.683 mg/L PBTK NA 50% Human Human +DTXSID6044642 Css NA 11.27 mg/L PBTK NA 95% Human Human +DTXSID6044642 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044642 Fup 0.0363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044642 Vd NA 0.4011 L/kg 1compartment NA NA Rat Human DTXSID6044642 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044642 TK.Half.Life NA 0.7336 hours 1compartment NA NA Rat Human -DTXSID6044642 Css NA 0.487 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044642 Css NA 3.597 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044642 Css NA 0.2688 mg/L PBTK NA 50% Rat Human -DTXSID6044642 Css NA 1.984 mg/L PBTK NA 95% Rat Human -DTXSID6044644 Clint NA 11.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044644 Fup NA 0.4224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044644 Vd NA 0.8794 L/kg 1compartment NA NA Human Human +DTXSID6044642 TK.Half.Life NA 3.925 hours 1compartment NA NA Rat Human +DTXSID6044642 Css NA 0.347 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044642 Css NA 1.842 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044642 Css NA 0.2042 mg/L PBTK NA 50% Rat Human +DTXSID6044642 Css NA 1.049 mg/L PBTK NA 95% Rat Human +DTXSID6044644 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044644 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044644 Vd NA 0.6297 L/kg 1compartment NA NA Human Human DTXSID6044644 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044644 TK.Half.Life NA 1.245 hours 1compartment NA NA Human Human -DTXSID6044644 Css NA 0.0921 mg/L 3compartmentss NA 50% Human Human -DTXSID6044644 Css NA 0.6592 mg/L 3compartmentss NA 95% Human Human -DTXSID6044644 Css NA 0.07124 mg/L PBTK NA 50% Human Human -DTXSID6044644 Css NA 0.4489 mg/L PBTK NA 95% Human Human -DTXSID6044644 Clint NA 11.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044644 Fup NA 0.4224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044644 Vd NA 0.8067 L/kg 1compartment NA NA Rat Human +DTXSID6044644 TK.Half.Life NA 1.306 hours 1compartment NA NA Human Human +DTXSID6044644 Css NA 0.1672 mg/L 3compartmentss NA 50% Human Human +DTXSID6044644 Css NA 1.098 mg/L 3compartmentss NA 95% Human Human +DTXSID6044644 Css NA 0.124 mg/L PBTK NA 50% Human Human +DTXSID6044644 Css NA 0.7282 mg/L PBTK NA 95% Human Human +DTXSID6044644 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044644 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044644 Vd NA 0.6146 L/kg 1compartment NA NA Rat Human DTXSID6044644 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044644 TK.Half.Life NA 0.6107 hours 1compartment NA NA Rat Human -DTXSID6044644 Css NA 0.0468 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044644 Css NA 0.2766 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044644 Css NA 0.03506 mg/L PBTK NA 50% Rat Human -DTXSID6044644 Css NA 0.1799 mg/L PBTK NA 95% Rat Human -DTXSID6044646 Clint NA 891.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044646 Fup NA 0.1405 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044646 Vd NA 1.91 L/kg 1compartment NA NA Human Human +DTXSID6044644 TK.Half.Life NA 0.7113 hours 1compartment NA NA Rat Human +DTXSID6044644 Css NA 0.01931 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044644 Css NA 0.09684 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044644 Css NA 0.01416 mg/L PBTK NA 50% Rat Human +DTXSID6044644 Css NA 0.06164 mg/L PBTK NA 95% Rat Human +DTXSID6044646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044646 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044646 Vd NA 1.733 L/kg 1compartment NA NA Human Human DTXSID6044646 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044646 TK.Half.Life NA 1.61 hours 1compartment NA NA Human Human -DTXSID6044646 Css NA 0.006172 mg/L 3compartmentss NA 50% Human Human -DTXSID6044646 Css NA 0.04836 mg/L 3compartmentss NA 95% Human Human -DTXSID6044646 Css NA 0.004261 mg/L PBTK NA 50% Human Human -DTXSID6044646 Css NA 0.03172 mg/L PBTK NA 95% Human Human -DTXSID6044646 Clint NA 891.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044646 Fup NA 0.1405 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044646 Vd NA 1.462 L/kg 1compartment NA NA Rat Human +DTXSID6044646 TK.Half.Life NA 4.774 hours 1compartment NA NA Human Human +DTXSID6044646 Css NA 0.2844 mg/L 3compartmentss NA 50% Human Human +DTXSID6044646 Css NA 2.141 mg/L 3compartmentss NA 95% Human Human +DTXSID6044646 Css NA 0.1924 mg/L PBTK NA 50% Human Human +DTXSID6044646 Css NA 1.338 mg/L PBTK NA 95% Human Human +DTXSID6044646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044646 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044646 Vd NA 1.323 L/kg 1compartment NA NA Rat Human DTXSID6044646 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044646 TK.Half.Life NA 0.5382 hours 1compartment NA NA Rat Human -DTXSID6044646 Css NA 0.003536 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044646 Css NA 0.0222 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044646 Css NA 0.002319 mg/L PBTK NA 50% Rat Human -DTXSID6044646 Css NA 0.01359 mg/L PBTK NA 95% Rat Human -DTXSID6044648 Clint NA 217.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044648 Fup NA 0.0372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044648 Vd NA 0.6765 L/kg 1compartment NA NA Human Human +DTXSID6044646 TK.Half.Life NA 1.736 hours 1compartment NA NA Rat Human +DTXSID6044646 Css NA 0.03624 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044646 Css NA 0.2159 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044646 Css NA 0.02409 mg/L PBTK NA 50% Rat Human +DTXSID6044646 Css NA 0.1358 mg/L PBTK NA 95% Rat Human +DTXSID6044648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044648 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044648 Vd NA 1.225 L/kg 1compartment NA NA Human Human DTXSID6044648 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044648 TK.Half.Life NA 0.9367 hours 1compartment NA NA Human Human -DTXSID6044648 Css NA 0.08548 mg/L 3compartmentss NA 50% Human Human -DTXSID6044648 Css NA 0.8642 mg/L 3compartmentss NA 95% Human Human -DTXSID6044648 Css NA 0.05242 mg/L PBTK NA 50% Human Human -DTXSID6044648 Css NA 0.5107 mg/L PBTK NA 95% Human Human -DTXSID6044648 Clint NA 217.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044648 Fup NA 0.0372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044648 Vd NA 0.5259 L/kg 1compartment NA NA Rat Human +DTXSID6044648 TK.Half.Life NA 2.212 hours 1compartment NA NA Human Human +DTXSID6044648 Css NA 0.1256 mg/L 3compartmentss NA 50% Human Human +DTXSID6044648 Css NA 0.8935 mg/L 3compartmentss NA 95% Human Human +DTXSID6044648 Css NA 0.08738 mg/L PBTK NA 50% Human Human +DTXSID6044648 Css NA 0.6002 mg/L PBTK NA 95% Human Human +DTXSID6044648 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044648 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044648 Vd NA 0.9804 L/kg 1compartment NA NA Rat Human DTXSID6044648 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044648 TK.Half.Life NA 0.3727 hours 1compartment NA NA Rat Human -DTXSID6044648 Css NA 0.05005 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044648 Css NA 0.3749 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044648 Css NA 0.02844 mg/L PBTK NA 50% Rat Human -DTXSID6044648 Css NA 0.2082 mg/L PBTK NA 95% Rat Human -DTXSID6044690 Clint NA 102 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044690 Fup NA 0.0352 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044690 Vd NA 2.736 L/kg 1compartment NA NA Human Human -DTXSID6044690 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044690 TK.Half.Life NA 8.178 hours 1compartment NA NA Human Human -DTXSID6044690 Css NA 0.3014 mg/L 3compartmentss NA 50% Human Human -DTXSID6044690 Css NA 1.974 mg/L 3compartmentss NA 95% Human Human -DTXSID6044690 Css NA 0.2038 mg/L PBTK NA 50% Human Human -DTXSID6044690 Css NA 1.287 mg/L PBTK NA 95% Human Human -DTXSID6044690 Clint NA 102 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044690 Fup NA 0.0352 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044690 Vd NA 2.048 L/kg 1compartment NA NA Rat Human -DTXSID6044690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044690 TK.Half.Life NA 1.943 hours 1compartment NA NA Rat Human -DTXSID6044690 Css NA 0.1693 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044690 Css NA 0.9261 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044690 Css NA 0.1093 mg/L PBTK NA 50% Rat Human -DTXSID6044690 Css NA 0.5822 mg/L PBTK NA 95% Rat Human -DTXSID6044692 Clint NA 37.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044692 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044692 Vd NA 0.8566 L/kg 1compartment NA NA Human Human +DTXSID6044648 TK.Half.Life NA 0.9222 hours 1compartment NA NA Rat Human +DTXSID6044648 Css NA 0.01627 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044648 Css NA 0.08502 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044648 Css NA 0.01126 mg/L PBTK NA 50% Rat Human +DTXSID6044648 Css NA 0.0558 mg/L PBTK NA 95% Rat Human +DTXSID6044690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044690 Fup 0.0126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044690 Vd NA 2.65 L/kg 1compartment NA NA Human Human +DTXSID6044690 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID6044690 TK.Half.Life NA 45.22 hours 1compartment NA NA Human Human +DTXSID6044690 Css NA 2.338 mg/L 3compartmentss NA 50% Human Human +DTXSID6044690 Css NA 16.63 mg/L 3compartmentss NA 95% Human Human +DTXSID6044690 Css NA 1.563 mg/L PBTK NA 50% Human Human +DTXSID6044690 Css NA 10.72 mg/L PBTK NA 95% Human Human +DTXSID6044690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044690 Fup 0.0126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044690 Vd NA 1.978 L/kg 1compartment NA NA Rat Human +DTXSID6044690 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6044690 TK.Half.Life NA 9.963 hours 1compartment NA NA Rat Human +DTXSID6044690 Css NA 0.3052 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044690 Css NA 1.898 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044690 Css NA 0.1997 mg/L PBTK NA 50% Rat Human +DTXSID6044690 Css NA 1.205 mg/L PBTK NA 95% Rat Human +DTXSID6044692 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044692 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044692 Vd NA 1.675 L/kg 1compartment NA NA Human Human DTXSID6044692 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044692 TK.Half.Life NA 0.8857 hours 1compartment NA NA Human Human -DTXSID6044692 Css NA 0.0387 mg/L 3compartmentss NA 50% Human Human -DTXSID6044692 Css NA 0.2997 mg/L 3compartmentss NA 95% Human Human -DTXSID6044692 Css NA 0.02872 mg/L PBTK NA 50% Human Human -DTXSID6044692 Css NA 0.2061 mg/L PBTK NA 95% Human Human -DTXSID6044692 Clint NA 37.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044692 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044692 Vd NA 0.8182 L/kg 1compartment NA NA Rat Human +DTXSID6044692 TK.Half.Life NA 2.989 hours 1compartment NA NA Human Human +DTXSID6044692 Css NA 0.1268 mg/L 3compartmentss NA 50% Human Human +DTXSID6044692 Css NA 1.025 mg/L 3compartmentss NA 95% Human Human +DTXSID6044692 Css NA 0.11 mg/L PBTK NA 50% Human Human +DTXSID6044692 Css NA 0.74 mg/L PBTK NA 95% Human Human +DTXSID6044692 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044692 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044692 Vd NA 1.502 L/kg 1compartment NA NA Rat Human DTXSID6044692 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044692 TK.Half.Life NA 0.4247 hours 1compartment NA NA Rat Human -DTXSID6044692 Css NA 0.02098 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044692 Css NA 0.1287 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044692 Css NA 0.015 mg/L PBTK NA 50% Rat Human -DTXSID6044692 Css NA 0.08285 mg/L PBTK NA 95% Rat Human -DTXSID6044696 Clint NA 112.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044696 Fup NA 0.6556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044696 Vd NA 0.8566 L/kg 1compartment NA NA Human Human +DTXSID6044692 TK.Half.Life NA 1.382 hours 1compartment NA NA Rat Human +DTXSID6044692 Css NA 0.01468 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044692 Css NA 0.08684 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044692 Css NA 0.01289 mg/L PBTK NA 50% Rat Human +DTXSID6044692 Css NA 0.05996 mg/L PBTK NA 95% Rat Human +DTXSID6044696 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044696 Fup 0.643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044696 Vd NA 0.7927 L/kg 1compartment NA NA Human Human DTXSID6044696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044696 TK.Half.Life NA 0.5747 hours 1compartment NA NA Human Human -DTXSID6044696 Css NA 0.006555 mg/L 3compartmentss NA 50% Human Human -DTXSID6044696 Css NA 0.07428 mg/L 3compartmentss NA 95% Human Human -DTXSID6044696 Css NA 0.005328 mg/L PBTK NA 50% Human Human -DTXSID6044696 Css NA 0.05136 mg/L PBTK NA 95% Human Human -DTXSID6044696 Clint NA 112.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044696 Fup NA 0.6556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044696 Vd NA 0.8758 L/kg 1compartment NA NA Rat Human +DTXSID6044696 TK.Half.Life NA 7.978 hours 1compartment NA NA Human Human +DTXSID6044696 Css NA 0.987 mg/L 3compartmentss NA 50% Human Human +DTXSID6044696 Css NA 6.879 mg/L 3compartmentss NA 95% Human Human +DTXSID6044696 Css NA 0.8044 mg/L PBTK NA 50% Human Human +DTXSID6044696 Css NA 4.354 mg/L PBTK NA 95% Human Human +DTXSID6044696 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044696 Fup 0.643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044696 Vd NA 0.8164 L/kg 1compartment NA NA Rat Human DTXSID6044696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044696 TK.Half.Life NA 0.2632 hours 1compartment NA NA Rat Human -DTXSID6044696 Css NA 0.003481 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044696 Css NA 0.03441 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044696 Css NA 0.002758 mg/L PBTK NA 50% Rat Human -DTXSID6044696 Css NA 0.02315 mg/L PBTK NA 95% Rat Human -DTXSID6044721 Clint NA 0.0149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044721 Fup NA 0.8145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044721 Vd NA 2.171 L/kg 1compartment NA NA Human Human -DTXSID6044721 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6044721 TK.Half.Life NA 16.83 hours 1compartment NA NA Human Human -DTXSID6044721 Css NA 0.7424 mg/L 3compartmentss NA 50% Human Human -DTXSID6044721 Css NA 5.255 mg/L 3compartmentss NA 95% Human Human -DTXSID6044721 Css NA 0.7808 mg/L PBTK NA 50% Human Human -DTXSID6044721 Css NA 3.722 mg/L PBTK NA 95% Human Human -DTXSID6044721 Clint NA 0.0149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044721 Fup NA 0.8145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044721 Vd NA 2.181 L/kg 1compartment NA NA Rat Human +DTXSID6044696 TK.Half.Life NA 2.799 hours 1compartment NA NA Rat Human +DTXSID6044696 Css NA 0.02622 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044696 Css NA 0.1959 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044696 Css NA 0.02048 mg/L PBTK NA 50% Rat Human +DTXSID6044696 Css NA 0.1243 mg/L PBTK NA 95% Rat Human +DTXSID6044721 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044721 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044721 Vd NA 1.61 L/kg 1compartment NA NA Human Human +DTXSID6044721 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6044721 TK.Half.Life NA 19.76 hours 1compartment NA NA Human Human +DTXSID6044721 Css NA 0.9726 mg/L 3compartmentss NA 50% Human Human +DTXSID6044721 Css NA 6.206 mg/L 3compartmentss NA 95% Human Human +DTXSID6044721 Css NA 0.9098 mg/L PBTK NA 50% Human Human +DTXSID6044721 Css NA 4.156 mg/L PBTK NA 95% Human Human +DTXSID6044721 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044721 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044721 Vd NA 1.61 L/kg 1compartment NA NA Rat Human DTXSID6044721 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044721 TK.Half.Life NA 5.835 hours 1compartment NA NA Rat Human -DTXSID6044721 Css NA 0.1871 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044721 Css NA 1.408 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044721 Css NA 0.1973 mg/L PBTK NA 50% Rat Human -DTXSID6044721 Css NA 0.916 mg/L PBTK NA 95% Rat Human -DTXSID6044723 Clint NA 0.00863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044723 Fup NA 0.7007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044723 Vd NA 0.9669 L/kg 1compartment NA NA Human Human -DTXSID6044723 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044723 TK.Half.Life NA 9.148 hours 1compartment NA NA Human Human -DTXSID6044723 Css NA 1 mg/L 3compartmentss NA 50% Human Human -DTXSID6044723 Css NA 6.609 mg/L 3compartmentss NA 95% Human Human -DTXSID6044723 Css NA 0.894 mg/L PBTK NA 50% Human Human -DTXSID6044723 Css NA 4.311 mg/L PBTK NA 95% Human Human -DTXSID6044723 Clint NA 0.00863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044723 Fup NA 0.7007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044723 Vd NA 0.9066 L/kg 1compartment NA NA Rat Human -DTXSID6044723 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044723 TK.Half.Life NA 2.86 hours 1compartment NA NA Rat Human -DTXSID6044723 Css NA 0.2588 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044723 Css NA 1.784 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044723 Css NA 0.2245 mg/L PBTK NA 50% Rat Human -DTXSID6044723 Css NA 1.085 mg/L PBTK NA 95% Rat Human -DTXSID6044725 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044725 Fup NA 0.8646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044725 Vd NA 0.6554 L/kg 1compartment NA NA Human Human +DTXSID6044721 TK.Half.Life NA 6.736 hours 1compartment NA NA Rat Human +DTXSID6044721 Css NA 0.0177 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044721 Css NA 0.1546 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044721 Css NA 0.01635 mg/L PBTK NA 50% Rat Human +DTXSID6044721 Css NA 0.1062 mg/L PBTK NA 95% Rat Human +DTXSID6044725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044725 Fup 0.808 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044725 Vd NA 0.6231 L/kg 1compartment NA NA Human Human DTXSID6044725 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044725 TK.Half.Life NA 4.93 hours 1compartment NA NA Human Human -DTXSID6044725 Css NA 0.9854 mg/L 3compartmentss NA 50% Human Human -DTXSID6044725 Css NA 5.36 mg/L 3compartmentss NA 95% Human Human -DTXSID6044725 Css NA 0.7836 mg/L PBTK NA 50% Human Human -DTXSID6044725 Css NA 3.505 mg/L PBTK NA 95% Human Human -DTXSID6044725 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044725 Fup NA 0.8646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044725 Vd NA 0.6561 L/kg 1compartment NA NA Rat Human +DTXSID6044725 TK.Half.Life NA 0.5085 hours 1compartment NA NA Human Human +DTXSID6044725 Css NA 0.02779 mg/L 3compartmentss NA 50% Human Human +DTXSID6044725 Css NA 0.2916 mg/L 3compartmentss NA 95% Human Human +DTXSID6044725 Css NA 0.02138 mg/L PBTK NA 50% Human Human +DTXSID6044725 Css NA 0.1991 mg/L PBTK NA 95% Human Human +DTXSID6044725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044725 Fup 0.808 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044725 Vd NA 0.6246 L/kg 1compartment NA NA Rat Human DTXSID6044725 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044725 TK.Half.Life NA 1.675 hours 1compartment NA NA Rat Human -DTXSID6044725 Css NA 0.2528 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044725 Css NA 1.456 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044725 Css NA 0.1941 mg/L PBTK NA 50% Rat Human -DTXSID6044725 Css NA 0.8612 mg/L PBTK NA 95% Rat Human -DTXSID6044771 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044771 Fup NA 0.7265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044771 Vd NA 0.5691 L/kg 1compartment NA NA Human Human +DTXSID6044725 TK.Half.Life NA 0.2446 hours 1compartment NA NA Rat Human +DTXSID6044725 Css NA 0.003276 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044725 Css NA 0.02999 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044725 Css NA 0.002591 mg/L PBTK NA 50% Rat Human +DTXSID6044725 Css NA 0.01994 mg/L PBTK NA 95% Rat Human +DTXSID6044771 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044771 Fup 0.559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044771 Vd NA 0.9037 L/kg 1compartment NA NA Human Human DTXSID6044771 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044771 TK.Half.Life NA 5.074 hours 1compartment NA NA Human Human -DTXSID6044771 Css NA 1.125 mg/L 3compartmentss NA 50% Human Human -DTXSID6044771 Css NA 6.883 mg/L 3compartmentss NA 95% Human Human -DTXSID6044771 Css NA 0.8582 mg/L PBTK NA 50% Human Human -DTXSID6044771 Css NA 4.303 mg/L PBTK NA 95% Human Human -DTXSID6044771 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044771 Fup NA 0.7265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044771 Vd NA 0.5833 L/kg 1compartment NA NA Rat Human +DTXSID6044771 TK.Half.Life NA 0.8582 hours 1compartment NA NA Human Human +DTXSID6044771 Css NA 0.0284 mg/L 3compartmentss NA 50% Human Human +DTXSID6044771 Css NA 0.3452 mg/L 3compartmentss NA 95% Human Human +DTXSID6044771 Css NA 0.02239 mg/L PBTK NA 50% Human Human +DTXSID6044771 Css NA 0.2342 mg/L PBTK NA 95% Human Human +DTXSID6044771 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044771 Fup 0.559 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044771 Vd NA 0.8179 L/kg 1compartment NA NA Rat Human DTXSID6044771 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044771 TK.Half.Life NA 1.771 hours 1compartment NA NA Rat Human -DTXSID6044771 Css NA 0.2966 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044771 Css NA 1.693 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044771 Css NA 0.2175 mg/L PBTK NA 50% Rat Human -DTXSID6044771 Css NA 0.9862 mg/L PBTK NA 95% Rat Human -DTXSID6044773 Clint NA 2.902 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044773 Fup NA 0.1583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044773 Vd NA 1.926 L/kg 1compartment NA NA Human Human -DTXSID6044773 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6044773 TK.Half.Life NA 20.95 hours 1compartment NA NA Human Human -DTXSID6044773 Css NA 1.361 mg/L 3compartmentss NA 50% Human Human -DTXSID6044773 Css NA 6.909 mg/L 3compartmentss NA 95% Human Human -DTXSID6044773 Css NA 0.9615 mg/L PBTK NA 50% Human Human -DTXSID6044773 Css NA 4.489 mg/L PBTK NA 95% Human Human -DTXSID6044773 Clint NA 2.902 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044773 Fup NA 0.1583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044773 Vd NA 1.477 L/kg 1compartment NA NA Rat Human +DTXSID6044771 TK.Half.Life NA 0.383 hours 1compartment NA NA Rat Human +DTXSID6044771 Css NA 0.001029 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044771 Css NA 0.01395 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044771 Css NA 0.0008032 mg/L PBTK NA 50% Rat Human +DTXSID6044771 Css NA 0.009121 mg/L PBTK NA 95% Rat Human +DTXSID6044773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044773 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044773 Vd NA 2.139 L/kg 1compartment NA NA Human Human +DTXSID6044773 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044773 TK.Half.Life NA 6.502 hours 1compartment NA NA Human Human +DTXSID6044773 Css NA 0.3107 mg/L 3compartmentss NA 50% Human Human +DTXSID6044773 Css NA 2.237 mg/L 3compartmentss NA 95% Human Human +DTXSID6044773 Css NA 0.215 mg/L PBTK NA 50% Human Human +DTXSID6044773 Css NA 1.428 mg/L PBTK NA 95% Human Human +DTXSID6044773 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044773 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044773 Vd NA 1.624 L/kg 1compartment NA NA Rat Human DTXSID6044773 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044773 TK.Half.Life NA 6.595 hours 1compartment NA NA Rat Human -DTXSID6044773 Css NA 0.6656 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044773 Css NA 2.437 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044773 Css NA 0.4448 mg/L PBTK NA 50% Rat Human -DTXSID6044773 Css NA 1.457 mg/L PBTK NA 95% Rat Human -DTXSID6044777 Clint NA 33.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044777 Fup NA 0.3767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044777 Vd NA 0.9909 L/kg 1compartment NA NA Human Human -DTXSID6044777 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044777 TK.Half.Life NA 0.9856 hours 1compartment NA NA Human Human -DTXSID6044777 Css NA 0.03616 mg/L 3compartmentss NA 50% Human Human -DTXSID6044777 Css NA 0.2835 mg/L 3compartmentss NA 95% Human Human -DTXSID6044777 Css NA 0.02764 mg/L PBTK NA 50% Human Human -DTXSID6044777 Css NA 0.1931 mg/L PBTK NA 95% Human Human -DTXSID6044777 Clint NA 33.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044777 Fup NA 0.3767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044777 Vd NA 0.8732 L/kg 1compartment NA NA Rat Human +DTXSID6044773 TK.Half.Life NA 2.063 hours 1compartment NA NA Rat Human +DTXSID6044773 Css NA 0.03997 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044773 Css NA 0.2236 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044773 Css NA 0.02722 mg/L PBTK NA 50% Rat Human +DTXSID6044773 Css NA 0.1429 mg/L PBTK NA 95% Rat Human +DTXSID6044777 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044777 Fup 0.494 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044777 Vd NA 0.8233 L/kg 1compartment NA NA Human Human +DTXSID6044777 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6044777 TK.Half.Life NA 11.05 hours 1compartment NA NA Human Human +DTXSID6044777 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human +DTXSID6044777 Css NA 7.161 mg/L 3compartmentss NA 95% Human Human +DTXSID6044777 Css NA 1.098 mg/L PBTK NA 50% Human Human +DTXSID6044777 Css NA 4.639 mg/L PBTK NA 95% Human Human +DTXSID6044777 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044777 Fup 0.494 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044777 Vd NA 0.781 L/kg 1compartment NA NA Rat Human DTXSID6044777 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044777 TK.Half.Life NA 0.4281 hours 1compartment NA NA Rat Human -DTXSID6044777 Css NA 0.0195 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044777 Css NA 0.1232 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044777 Css NA 0.01438 mg/L PBTK NA 50% Rat Human -DTXSID6044777 Css NA 0.08117 mg/L PBTK NA 95% Rat Human -DTXSID6044779 Clint NA 1.332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044779 Fup NA 0.4946 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044779 Vd NA 1.193 L/kg 1compartment NA NA Human Human +DTXSID6044777 TK.Half.Life NA 3.506 hours 1compartment NA NA Rat Human +DTXSID6044777 Css NA 0.08777 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044777 Css NA 0.4017 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044777 Css NA 0.06936 mg/L PBTK NA 50% Rat Human +DTXSID6044777 Css NA 0.2501 mg/L PBTK NA 95% Rat Human +DTXSID6044779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044779 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044779 Vd NA 1.556 L/kg 1compartment NA NA Human Human DTXSID6044779 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044779 TK.Half.Life NA 5.622 hours 1compartment NA NA Human Human -DTXSID6044779 Css NA 0.4561 mg/L 3compartmentss NA 50% Human Human -DTXSID6044779 Css NA 2.859 mg/L 3compartmentss NA 95% Human Human -DTXSID6044779 Css NA 0.3764 mg/L PBTK NA 50% Human Human -DTXSID6044779 Css NA 1.898 mg/L PBTK NA 95% Human Human -DTXSID6044779 Clint NA 1.332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044779 Fup NA 0.4946 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044779 Vd NA 1.049 L/kg 1compartment NA NA Rat Human +DTXSID6044779 TK.Half.Life NA 1.686 hours 1compartment NA NA Human Human +DTXSID6044779 Css NA 0.04724 mg/L 3compartmentss NA 50% Human Human +DTXSID6044779 Css NA 0.4085 mg/L 3compartmentss NA 95% Human Human +DTXSID6044779 Css NA 0.03888 mg/L PBTK NA 50% Human Human +DTXSID6044779 Css NA 0.294 mg/L PBTK NA 95% Human Human +DTXSID6044779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044779 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044779 Vd NA 1.295 L/kg 1compartment NA NA Rat Human DTXSID6044779 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044779 TK.Half.Life NA 2.356 hours 1compartment NA NA Rat Human -DTXSID6044779 Css NA 0.1909 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044779 Css NA 0.9605 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044779 Css NA 0.1531 mg/L PBTK NA 50% Rat Human -DTXSID6044779 Css NA 0.5921 mg/L PBTK NA 95% Rat Human -DTXSID6044800 Clint NA 2.033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044800 Fup NA 0.2283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044800 Vd NA 1.052 L/kg 1compartment NA NA Human Human +DTXSID6044779 TK.Half.Life NA 0.673 hours 1compartment NA NA Rat Human +DTXSID6044779 Css NA 0.005836 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044779 Css NA 0.03649 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044779 Css NA 0.00481 mg/L PBTK NA 50% Rat Human +DTXSID6044779 Css NA 0.02628 mg/L PBTK NA 95% Rat Human +DTXSID6044800 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044800 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044800 Vd NA 0.4014 L/kg 1compartment NA NA Human Human DTXSID6044800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044800 TK.Half.Life NA 7.918 hours 1compartment NA NA Human Human -DTXSID6044800 Css NA 0.8466 mg/L 3compartmentss NA 50% Human Human -DTXSID6044800 Css NA 4.098 mg/L 3compartmentss NA 95% Human Human -DTXSID6044800 Css NA 0.5978 mg/L PBTK NA 50% Human Human -DTXSID6044800 Css NA 2.642 mg/L PBTK NA 95% Human Human -DTXSID6044800 Clint NA 2.033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044800 Fup NA 0.2283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044800 Vd NA 0.8507 L/kg 1compartment NA NA Rat Human +DTXSID6044800 TK.Half.Life NA 9.409 hours 1compartment NA NA Human Human +DTXSID6044800 Css NA 2.729 mg/L 3compartmentss NA 50% Human Human +DTXSID6044800 Css NA 10.37 mg/L 3compartmentss NA 95% Human Human +DTXSID6044800 Css NA 1.864 mg/L PBTK NA 50% Human Human +DTXSID6044800 Css NA 6.43 mg/L PBTK NA 95% Human Human +DTXSID6044800 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044800 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044800 Vd NA 0.4135 L/kg 1compartment NA NA Rat Human DTXSID6044800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044800 TK.Half.Life NA 3.213 hours 1compartment NA NA Rat Human -DTXSID6044800 Css NA 0.3858 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044800 Css NA 1.349 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044800 Css NA 0.2613 mg/L PBTK NA 50% Rat Human -DTXSID6044800 Css NA 0.8078 mg/L PBTK NA 95% Rat Human -DTXSID6044802 Clint NA 78.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044802 Fup NA 0.0166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044802 Vd NA 1.643 L/kg 1compartment NA NA Human Human -DTXSID6044802 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044802 TK.Half.Life NA 5.996 hours 1compartment NA NA Human Human -DTXSID6044802 Css NA 0.4872 mg/L 3compartmentss NA 50% Human Human -DTXSID6044802 Css NA 4.199 mg/L 3compartmentss NA 95% Human Human -DTXSID6044802 Css NA 0.3062 mg/L PBTK NA 50% Human Human -DTXSID6044802 Css NA 2.546 mg/L PBTK NA 95% Human Human -DTXSID6044802 Clint NA 78.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044802 Fup NA 0.0166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044802 Vd NA 1.217 L/kg 1compartment NA NA Rat Human -DTXSID6044802 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044802 TK.Half.Life NA 2.18 hours 1compartment NA NA Rat Human -DTXSID6044802 Css NA 0.2712 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044802 Css NA 2.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044802 Css NA 0.1604 mg/L PBTK NA 50% Rat Human -DTXSID6044802 Css NA 1.171 mg/L PBTK NA 95% Rat Human -DTXSID6044804 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044804 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044804 Vd NA 0.7748 L/kg 1compartment NA NA Human Human +DTXSID6044800 TK.Half.Life NA 3.304 hours 1compartment NA NA Rat Human +DTXSID6044800 Css NA 0.1762 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044800 Css NA 0.574 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044800 Css NA 0.1178 mg/L PBTK NA 50% Rat Human +DTXSID6044800 Css NA 0.3428 mg/L PBTK NA 95% Rat Human +DTXSID6044802 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044802 Fup 0.0186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044802 Vd NA 3.029 L/kg 1compartment NA NA Human Human +DTXSID6044802 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID6044802 TK.Half.Life NA 66.65 hours 1compartment NA NA Human Human +DTXSID6044802 Css NA 2.706 mg/L 3compartmentss NA 50% Human Human +DTXSID6044802 Css NA 17.28 mg/L 3compartmentss NA 95% Human Human +DTXSID6044802 Css NA 1.86 mg/L PBTK NA 50% Human Human +DTXSID6044802 Css NA 11.58 mg/L PBTK NA 95% Human Human +DTXSID6044802 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044802 Fup 0.0186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044802 Vd NA 2.268 L/kg 1compartment NA NA Rat Human +DTXSID6044802 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID6044802 TK.Half.Life NA 10.21 hours 1compartment NA NA Rat Human +DTXSID6044802 Css NA 0.3499 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044802 Css NA 1.932 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044802 Css NA 0.2379 mg/L PBTK NA 50% Rat Human +DTXSID6044802 Css NA 1.289 mg/L PBTK NA 95% Rat Human +DTXSID6044804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044804 Fup 0.797 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044804 Vd NA 0.9015 L/kg 1compartment NA NA Human Human DTXSID6044804 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044804 TK.Half.Life NA 5.016 hours 1compartment NA NA Human Human -DTXSID6044804 Css NA 0.8296 mg/L 3compartmentss NA 50% Human Human -DTXSID6044804 Css NA 5.565 mg/L 3compartmentss NA 95% Human Human -DTXSID6044804 Css NA 0.6988 mg/L PBTK NA 50% Human Human -DTXSID6044804 Css NA 3.648 mg/L PBTK NA 95% Human Human -DTXSID6044804 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044804 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044804 Vd NA 0.8131 L/kg 1compartment NA NA Rat Human +DTXSID6044804 TK.Half.Life NA 0.6934 hours 1compartment NA NA Human Human +DTXSID6044804 Css NA 0.0205 mg/L 3compartmentss NA 50% Human Human +DTXSID6044804 Css NA 0.2339 mg/L 3compartmentss NA 95% Human Human +DTXSID6044804 Css NA 0.01713 mg/L PBTK NA 50% Human Human +DTXSID6044804 Css NA 0.1703 mg/L PBTK NA 95% Human Human +DTXSID6044804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044804 Fup 0.797 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044804 Vd NA 0.8969 L/kg 1compartment NA NA Rat Human DTXSID6044804 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044804 TK.Half.Life NA 1.793 hours 1compartment NA NA Rat Human -DTXSID6044804 Css NA 0.2082 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044804 Css NA 1.329 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044804 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID6044804 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID6044854 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044854 Fup NA 0.9169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044854 Vd NA 1.56 L/kg 1compartment NA NA Human Human -DTXSID6044854 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6044854 TK.Half.Life NA 12.58 hours 1compartment NA NA Human Human -DTXSID6044854 Css NA 0.8079 mg/L 3compartmentss NA 50% Human Human -DTXSID6044854 Css NA 3.204 mg/L 3compartmentss NA 95% Human Human -DTXSID6044854 Css NA 0.7668 mg/L PBTK NA 50% Human Human -DTXSID6044854 Css NA 2.427 mg/L PBTK NA 95% Human Human -DTXSID6044854 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044854 Fup NA 0.9169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044854 Vd NA 1.404 L/kg 1compartment NA NA Rat Human +DTXSID6044804 TK.Half.Life NA 0.3344 hours 1compartment NA NA Rat Human +DTXSID6044804 Css NA 0.0007255 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044804 Css NA 0.009838 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044804 Css NA 0.000599 mg/L PBTK NA 50% Rat Human +DTXSID6044804 Css NA 0.006982 mg/L PBTK NA 95% Rat Human +DTXSID6044852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044852 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044852 Vd NA 1.847 L/kg 1compartment NA NA Human Human +DTXSID6044852 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044852 TK.Half.Life NA 3.167 hours 1compartment NA NA Human Human +DTXSID6044852 Css NA 0.1152 mg/L 3compartmentss NA 50% Human Human +DTXSID6044852 Css NA 0.7768 mg/L 3compartmentss NA 95% Human Human +DTXSID6044852 Css NA 0.08542 mg/L PBTK NA 50% Human Human +DTXSID6044852 Css NA 0.5437 mg/L PBTK NA 95% Human Human +DTXSID6044852 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044852 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044852 Vd NA 1.465 L/kg 1compartment NA NA Rat Human +DTXSID6044852 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6044852 TK.Half.Life NA 1.175 hours 1compartment NA NA Rat Human +DTXSID6044852 Css NA 0.01444 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044852 Css NA 0.07493 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044852 Css NA 0.01069 mg/L PBTK NA 50% Rat Human +DTXSID6044852 Css NA 0.05268 mg/L PBTK NA 95% Rat Human +DTXSID6044854 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044854 Fup 0.697 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044854 Vd NA 1.286 L/kg 1compartment NA NA Human Human +DTXSID6044854 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044854 TK.Half.Life NA 1.05 hours 1compartment NA NA Human Human +DTXSID6044854 Css NA 0.02187 mg/L 3compartmentss NA 50% Human Human +DTXSID6044854 Css NA 0.2678 mg/L 3compartmentss NA 95% Human Human +DTXSID6044854 Css NA 0.01901 mg/L PBTK NA 50% Human Human +DTXSID6044854 Css NA 0.1912 mg/L PBTK NA 95% Human Human +DTXSID6044854 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044854 Fup 0.697 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044854 Vd NA 1.164 L/kg 1compartment NA NA Rat Human DTXSID6044854 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044854 TK.Half.Life NA 3.492 hours 1compartment NA NA Rat Human -DTXSID6044854 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044854 Css NA 0.8075 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044854 Css NA 0.1951 mg/L PBTK NA 50% Rat Human -DTXSID6044854 Css NA 0.5503 mg/L PBTK NA 95% Rat Human -DTXSID6044856 Clint NA 59.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044856 Fup NA 0.0821 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044856 Vd NA 1.844 L/kg 1compartment NA NA Human Human +DTXSID6044854 TK.Half.Life NA 0.4593 hours 1compartment NA NA Rat Human +DTXSID6044854 Css NA 0.0007918 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044854 Css NA 0.01109 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044854 Css NA 0.0006826 mg/L PBTK NA 50% Rat Human +DTXSID6044854 Css NA 0.007716 mg/L PBTK NA 95% Rat Human +DTXSID6044856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044856 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044856 Vd NA 2.39 L/kg 1compartment NA NA Human Human DTXSID6044856 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044856 TK.Half.Life NA 2.826 hours 1compartment NA NA Human Human -DTXSID6044856 Css NA 0.1164 mg/L 3compartmentss NA 50% Human Human -DTXSID6044856 Css NA 0.9557 mg/L 3compartmentss NA 95% Human Human -DTXSID6044856 Css NA 0.08267 mg/L PBTK NA 50% Human Human -DTXSID6044856 Css NA 0.6476 mg/L PBTK NA 95% Human Human -DTXSID6044856 Clint NA 59.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044856 Fup NA 0.0821 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044856 Vd NA 1.603 L/kg 1compartment NA NA Rat Human +DTXSID6044856 TK.Half.Life NA 3.83 hours 1compartment NA NA Human Human +DTXSID6044856 Css NA 0.09802 mg/L 3compartmentss NA 50% Human Human +DTXSID6044856 Css NA 0.7125 mg/L 3compartmentss NA 95% Human Human +DTXSID6044856 Css NA 0.08366 mg/L PBTK NA 50% Human Human +DTXSID6044856 Css NA 0.5378 mg/L PBTK NA 95% Human Human +DTXSID6044856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044856 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044856 Vd NA 2.18 L/kg 1compartment NA NA Rat Human DTXSID6044856 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044856 TK.Half.Life NA 1.255 hours 1compartment NA NA Rat Human -DTXSID6044856 Css NA 0.0652 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044856 Css NA 0.4422 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044856 Css NA 0.04408 mg/L PBTK NA 50% Rat Human -DTXSID6044856 Css NA 0.273 mg/L PBTK NA 95% Rat Human -DTXSID6044858 Clint NA 0.007046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044858 Fup NA 0.155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044858 Vd NA 0.3521 L/kg 1compartment NA NA Human Human -DTXSID6044858 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6044858 TK.Half.Life NA 14.53 hours 1compartment NA NA Human Human -DTXSID6044858 Css NA 5.659 mg/L 3compartmentss NA 50% Human Human -DTXSID6044858 Css NA 25.75 mg/L 3compartmentss NA 95% Human Human -DTXSID6044858 Css NA 3.668 mg/L PBTK NA 50% Human Human -DTXSID6044858 Css NA 15.25 mg/L PBTK NA 95% Human Human -DTXSID6044858 Clint NA 0.007046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044858 Fup NA 0.155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044858 Vd NA 0.3498 L/kg 1compartment NA NA Rat Human +DTXSID6044856 TK.Half.Life NA 1.788 hours 1compartment NA NA Rat Human +DTXSID6044856 Css NA 0.01224 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044856 Css NA 0.06627 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044856 Css NA 0.01045 mg/L PBTK NA 50% Rat Human +DTXSID6044856 Css NA 0.05058 mg/L PBTK NA 95% Rat Human +DTXSID6044858 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044858 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044858 Vd NA 0.4901 L/kg 1compartment NA NA Human Human +DTXSID6044858 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6044858 TK.Half.Life NA 0.6336 hours 1compartment NA NA Human Human +DTXSID6044858 Css NA 0.06598 mg/L 3compartmentss NA 50% Human Human +DTXSID6044858 Css NA 0.502 mg/L 3compartmentss NA 95% Human Human +DTXSID6044858 Css NA 0.04742 mg/L PBTK NA 50% Human Human +DTXSID6044858 Css NA 0.3381 mg/L PBTK NA 95% Human Human +DTXSID6044858 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044858 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044858 Vd NA 0.4895 L/kg 1compartment NA NA Rat Human DTXSID6044858 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044858 TK.Half.Life NA 4.948 hours 1compartment NA NA Rat Human -DTXSID6044858 Css NA 1.632 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044858 Css NA 6.185 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044858 Css NA 0.9938 mg/L PBTK NA 50% Rat Human -DTXSID6044858 Css NA 3.463 mg/L PBTK NA 95% Rat Human -DTXSID6044931 Clint NA 35.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044931 Fup NA 0.6096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044931 Vd NA 2.826 L/kg 1compartment NA NA Human Human -DTXSID6044931 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044931 TK.Half.Life NA 1.667 hours 1compartment NA NA Human Human -DTXSID6044931 Css NA 0.0153 mg/L 3compartmentss NA 50% Human Human -DTXSID6044931 Css NA 0.1956 mg/L 3compartmentss NA 95% Human Human -DTXSID6044931 Css NA 0.01765 mg/L PBTK NA 50% Human Human -DTXSID6044931 Css NA 0.1617 mg/L PBTK NA 95% Human Human -DTXSID6044931 Clint NA 35.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044931 Fup NA 0.6096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044931 Vd NA 2.837 L/kg 1compartment NA NA Rat Human -DTXSID6044931 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044931 TK.Half.Life NA 0.8343 hours 1compartment NA NA Rat Human -DTXSID6044931 Css NA 0.007612 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044931 Css NA 0.08687 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044931 Css NA 0.008816 mg/L PBTK NA 50% Rat Human -DTXSID6044931 Css NA 0.06824 mg/L PBTK NA 95% Rat Human -DTXSID6044933 Clint NA 0.7205 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044933 Fup NA 0.6482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044933 Vd NA 0.8622 L/kg 1compartment NA NA Human Human -DTXSID6044933 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044933 TK.Half.Life NA 4.151 hours 1compartment NA NA Human Human -DTXSID6044933 Css NA 0.5182 mg/L 3compartmentss NA 50% Human Human -DTXSID6044933 Css NA 3.715 mg/L 3compartmentss NA 95% Human Human -DTXSID6044933 Css NA 0.4289 mg/L PBTK NA 50% Human Human -DTXSID6044933 Css NA 2.382 mg/L PBTK NA 95% Human Human -DTXSID6044933 Clint NA 0.7205 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044933 Fup NA 0.6482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044933 Vd NA 0.8325 L/kg 1compartment NA NA Rat Human +DTXSID6044858 TK.Half.Life NA 0.337 hours 1compartment NA NA Rat Human +DTXSID6044858 Css NA 0.008312 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044858 Css NA 0.04834 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044858 Css NA 0.005948 mg/L PBTK NA 50% Rat Human +DTXSID6044858 Css NA 0.03199 mg/L PBTK NA 95% Rat Human +DTXSID6044931 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044931 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044931 Vd NA 3.397 L/kg 1compartment NA NA Human Human +DTXSID6044931 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6044931 TK.Half.Life NA 30.43 hours 1compartment NA NA Human Human +DTXSID6044931 Css NA 0.636 mg/L 3compartmentss NA 50% Human Human +DTXSID6044931 Css NA 5.72 mg/L 3compartmentss NA 95% Human Human +DTXSID6044931 Css NA 0.8308 mg/L PBTK NA 50% Human Human +DTXSID6044931 Css NA 4.323 mg/L PBTK NA 95% Human Human +DTXSID6044931 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044931 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044931 Vd NA 3.422 L/kg 1compartment NA NA Rat Human +DTXSID6044931 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6044931 TK.Half.Life NA 10.44 hours 1compartment NA NA Rat Human +DTXSID6044931 Css NA 0.0371 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044931 Css NA 0.3299 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044931 Css NA 0.05022 mg/L PBTK NA 50% Rat Human +DTXSID6044931 Css NA 0.239 mg/L PBTK NA 95% Rat Human +DTXSID6044933 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044933 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044933 Vd NA 0.6434 L/kg 1compartment NA NA Human Human +DTXSID6044933 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6044933 TK.Half.Life NA 9.923 hours 1compartment NA NA Human Human +DTXSID6044933 Css NA 1.654 mg/L 3compartmentss NA 50% Human Human +DTXSID6044933 Css NA 7.484 mg/L 3compartmentss NA 95% Human Human +DTXSID6044933 Css NA 1.244 mg/L PBTK NA 50% Human Human +DTXSID6044933 Css NA 4.802 mg/L PBTK NA 95% Human Human +DTXSID6044933 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044933 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044933 Vd NA 0.6249 L/kg 1compartment NA NA Rat Human DTXSID6044933 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044933 TK.Half.Life NA 1.828 hours 1compartment NA NA Rat Human -DTXSID6044933 Css NA 0.1885 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044933 Css NA 1.284 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044933 Css NA 0.151 mg/L PBTK NA 50% Rat Human -DTXSID6044933 Css NA 0.7568 mg/L PBTK NA 95% Rat Human -DTXSID6044935 Clint NA 2.274 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044935 Fup NA 0.9532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044935 Vd NA 0.9333 L/kg 1compartment NA NA Human Human -DTXSID6044935 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044935 TK.Half.Life NA 1.659 hours 1compartment NA NA Human Human -DTXSID6044935 Css NA 0.1895 mg/L 3compartmentss NA 50% Human Human -DTXSID6044935 Css NA 1.315 mg/L 3compartmentss NA 95% Human Human -DTXSID6044935 Css NA 0.1623 mg/L PBTK NA 50% Human Human -DTXSID6044935 Css NA 0.9254 mg/L PBTK NA 95% Human Human -DTXSID6044935 Clint NA 2.274 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044935 Fup NA 0.9532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044935 Vd NA 0.942 L/kg 1compartment NA NA Rat Human -DTXSID6044935 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044935 TK.Half.Life NA 0.8663 hours 1compartment NA NA Rat Human -DTXSID6044935 Css NA 0.07952 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044935 Css NA 0.4721 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044935 Css NA 0.06781 mg/L PBTK NA 50% Rat Human -DTXSID6044935 Css NA 0.2969 mg/L PBTK NA 95% Rat Human -DTXSID6044981 Clint NA 0.1177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044981 Fup NA 0.3131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044981 Vd NA 0.4343 L/kg 1compartment NA NA Human Human +DTXSID6044933 TK.Half.Life NA 3.257 hours 1compartment NA NA Rat Human +DTXSID6044933 Css NA 0.1056 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044933 Css NA 0.4154 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044933 Css NA 0.07817 mg/L PBTK NA 50% Rat Human +DTXSID6044933 Css NA 0.2556 mg/L PBTK NA 95% Rat Human +DTXSID6044981 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044981 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044981 Vd NA 0.4708 L/kg 1compartment NA NA Human Human DTXSID6044981 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044981 TK.Half.Life NA 7.476 hours 1compartment NA NA Human Human -DTXSID6044981 Css NA 1.973 mg/L 3compartmentss NA 50% Human Human -DTXSID6044981 Css NA 8.027 mg/L 3compartmentss NA 95% Human Human -DTXSID6044981 Css NA 1.388 mg/L PBTK NA 50% Human Human -DTXSID6044981 Css NA 5.017 mg/L PBTK NA 95% Human Human -DTXSID6044981 Clint NA 0.1177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044981 Fup NA 0.3131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044981 Vd NA 0.4419 L/kg 1compartment NA NA Rat Human +DTXSID6044981 TK.Half.Life NA 6.521 hours 1compartment NA NA Human Human +DTXSID6044981 Css NA 0.8526 mg/L 3compartmentss NA 50% Human Human +DTXSID6044981 Css NA 4.272 mg/L 3compartmentss NA 95% Human Human +DTXSID6044981 Css NA 0.6312 mg/L PBTK NA 50% Human Human +DTXSID6044981 Css NA 2.699 mg/L PBTK NA 95% Human Human +DTXSID6044981 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044981 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044981 Vd NA 0.4883 L/kg 1compartment NA NA Rat Human DTXSID6044981 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044981 TK.Half.Life NA 2.836 hours 1compartment NA NA Rat Human -DTXSID6044981 Css NA 0.6056 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044981 Css NA 2.101 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044981 Css NA 0.4037 mg/L PBTK NA 50% Rat Human -DTXSID6044981 Css NA 1.222 mg/L PBTK NA 95% Rat Human -DTXSID6044983 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044983 Fup NA 0.5781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044983 Vd NA 0.9172 L/kg 1compartment NA NA Human Human +DTXSID6044981 TK.Half.Life NA 2.306 hours 1compartment NA NA Rat Human +DTXSID6044981 Css NA 0.00463 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044981 Css NA 0.02344 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044981 Css NA 0.00326 mg/L PBTK NA 50% Rat Human +DTXSID6044981 Css NA 0.01415 mg/L PBTK NA 95% Rat Human +DTXSID6044983 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044983 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044983 Vd NA 1.039 L/kg 1compartment NA NA Human Human DTXSID6044983 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6044983 TK.Half.Life NA 10.57 hours 1compartment NA NA Human Human -DTXSID6044983 Css NA 1.273 mg/L 3compartmentss NA 50% Human Human -DTXSID6044983 Css NA 8.726 mg/L 3compartmentss NA 95% Human Human -DTXSID6044983 Css NA 1.045 mg/L PBTK NA 50% Human Human -DTXSID6044983 Css NA 5.542 mg/L PBTK NA 95% Human Human -DTXSID6044983 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044983 Fup NA 0.5781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044983 Vd NA 0.8695 L/kg 1compartment NA NA Rat Human +DTXSID6044983 TK.Half.Life NA 12.35 hours 1compartment NA NA Human Human +DTXSID6044983 Css NA 1.235 mg/L 3compartmentss NA 50% Human Human +DTXSID6044983 Css NA 8.84 mg/L 3compartmentss NA 95% Human Human +DTXSID6044983 Css NA 1.035 mg/L PBTK NA 50% Human Human +DTXSID6044983 Css NA 5.588 mg/L PBTK NA 95% Human Human +DTXSID6044983 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044983 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044983 Vd NA 0.9577 L/kg 1compartment NA NA Rat Human DTXSID6044983 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044983 TK.Half.Life NA 3.339 hours 1compartment NA NA Rat Human -DTXSID6044983 Css NA 0.3302 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044983 Css NA 2.113 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044983 Css NA 0.2626 mg/L PBTK NA 50% Rat Human -DTXSID6044983 Css NA 1.254 mg/L PBTK NA 95% Rat Human -DTXSID6044985 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044985 Fup NA 0.8847 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044985 Vd NA 1.403 L/kg 1compartment NA NA Human Human -DTXSID6044985 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6044985 TK.Half.Life NA 11.26 hours 1compartment NA NA Human Human -DTXSID6044985 Css NA 0.8722 mg/L 3compartmentss NA 50% Human Human -DTXSID6044985 Css NA 5.006 mg/L 3compartmentss NA 95% Human Human -DTXSID6044985 Css NA 0.8094 mg/L PBTK NA 50% Human Human -DTXSID6044985 Css NA 3.418 mg/L PBTK NA 95% Human Human -DTXSID6044985 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044985 Fup NA 0.8847 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044985 Vd NA 1.286 L/kg 1compartment NA NA Rat Human +DTXSID6044983 TK.Half.Life NA 3.731 hours 1compartment NA NA Rat Human +DTXSID6044983 Css NA 0.07484 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044983 Css NA 0.5083 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044983 Css NA 0.0627 mg/L PBTK NA 50% Rat Human +DTXSID6044983 Css NA 0.3128 mg/L PBTK NA 95% Rat Human +DTXSID6044985 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044985 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044985 Vd NA 1.649 L/kg 1compartment NA NA Human Human +DTXSID6044985 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6044985 TK.Half.Life NA 23.21 hours 1compartment NA NA Human Human +DTXSID6044985 Css NA 1.386 mg/L 3compartmentss NA 50% Human Human +DTXSID6044985 Css NA 8.563 mg/L 3compartmentss NA 95% Human Human +DTXSID6044985 Css NA 1.202 mg/L PBTK NA 50% Human Human +DTXSID6044985 Css NA 5.669 mg/L PBTK NA 95% Human Human +DTXSID6044985 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044985 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044985 Vd NA 1.392 L/kg 1compartment NA NA Rat Human DTXSID6044985 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044985 TK.Half.Life NA 3.279 hours 1compartment NA NA Rat Human -DTXSID6044985 Css NA 0.2191 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044985 Css NA 1.346 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044985 Css NA 0.1995 mg/L PBTK NA 50% Rat Human -DTXSID6044985 Css NA 0.8447 mg/L PBTK NA 95% Rat Human -DTXSID6044989 Clint NA 4.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044989 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6044989 Vd NA 2.274 L/kg 1compartment NA NA Human Human +DTXSID6044985 TK.Half.Life NA 5.603 hours 1compartment NA NA Rat Human +DTXSID6044985 Css NA 0.08486 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044985 Css NA 0.4979 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044985 Css NA 0.07392 mg/L PBTK NA 50% Rat Human +DTXSID6044985 Css NA 0.315 mg/L PBTK NA 95% Rat Human +DTXSID6044989 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044989 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6044989 Vd NA 1.493 L/kg 1compartment NA NA Human Human DTXSID6044989 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6044989 TK.Half.Life NA 9.148 hours 1compartment NA NA Human Human -DTXSID6044989 Css NA 0.394 mg/L 3compartmentss NA 50% Human Human -DTXSID6044989 Css NA 2.065 mg/L 3compartmentss NA 95% Human Human -DTXSID6044989 Css NA 0.308 mg/L PBTK NA 50% Human Human -DTXSID6044989 Css NA 1.472 mg/L PBTK NA 95% Human Human -DTXSID6044989 Clint NA 4.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044989 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6044989 Vd NA 1.779 L/kg 1compartment NA NA Rat Human +DTXSID6044989 TK.Half.Life NA 3.501 hours 1compartment NA NA Human Human +DTXSID6044989 Css NA 0.2214 mg/L 3compartmentss NA 50% Human Human +DTXSID6044989 Css NA 1.689 mg/L 3compartmentss NA 95% Human Human +DTXSID6044989 Css NA 0.1511 mg/L PBTK NA 50% Human Human +DTXSID6044989 Css NA 1.065 mg/L PBTK NA 95% Human Human +DTXSID6044989 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044989 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6044989 Vd NA 1.155 L/kg 1compartment NA NA Rat Human DTXSID6044989 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6044989 TK.Half.Life NA 2.744 hours 1compartment NA NA Rat Human -DTXSID6044989 Css NA 0.1941 mg/L 3compartmentss NA 50% Rat Human -DTXSID6044989 Css NA 0.7481 mg/L 3compartmentss NA 95% Rat Human -DTXSID6044989 Css NA 0.1467 mg/L PBTK NA 50% Rat Human -DTXSID6044989 Css NA 0.5044 mg/L PBTK NA 95% Rat Human -DTXSID6045082 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045082 Fup NA 0.2305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045082 Vd NA 3.345 L/kg 1compartment NA NA Human Human +DTXSID6044989 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Human +DTXSID6044989 Css NA 0.02916 mg/L 3compartmentss NA 50% Rat Human +DTXSID6044989 Css NA 0.1651 mg/L 3compartmentss NA 95% Rat Human +DTXSID6044989 Css NA 0.0193 mg/L PBTK NA 50% Rat Human +DTXSID6044989 Css NA 0.1051 mg/L PBTK NA 95% Rat Human +DTXSID6045082 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045082 Fup 0.304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045082 Vd NA 4.053 L/kg 1compartment NA NA Human Human DTXSID6045082 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045082 TK.Half.Life NA 10.2 hours 1compartment NA NA Human Human -DTXSID6045082 Css NA 0.2033 mg/L 3compartmentss NA 50% Human Human -DTXSID6045082 Css NA 1.38 mg/L 3compartmentss NA 95% Human Human -DTXSID6045082 Css NA 0.2334 mg/L PBTK NA 50% Human Human -DTXSID6045082 Css NA 1.245 mg/L PBTK NA 95% Human Human -DTXSID6045082 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045082 Fup NA 0.2305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045082 Vd NA 3.374 L/kg 1compartment NA NA Rat Human +DTXSID6045082 TK.Half.Life NA 3.373 hours 1compartment NA NA Human Human +DTXSID6045082 Css NA 0.02873 mg/L 3compartmentss NA 50% Human Human +DTXSID6045082 Css NA 0.2675 mg/L 3compartmentss NA 95% Human Human +DTXSID6045082 Css NA 0.0375 mg/L PBTK NA 50% Human Human +DTXSID6045082 Css NA 0.2685 mg/L PBTK NA 95% Human Human +DTXSID6045082 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045082 Fup 0.304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045082 Vd NA 4.106 L/kg 1compartment NA NA Rat Human DTXSID6045082 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045082 TK.Half.Life NA 6.129 hours 1compartment NA NA Rat Human -DTXSID6045082 Css NA 0.09898 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045082 Css NA 0.5191 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045082 Css NA 0.114 mg/L PBTK NA 50% Rat Human -DTXSID6045082 Css NA 0.4328 mg/L PBTK NA 95% Rat Human -DTXSID6045084 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045084 Fup NA 0.5662 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045084 Vd NA 0.6101 L/kg 1compartment NA NA Human Human +DTXSID6045082 TK.Half.Life NA 1.9 hours 1compartment NA NA Rat Human +DTXSID6045082 Css NA 0.003468 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045082 Css NA 0.02479 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045082 Css NA 0.004787 mg/L PBTK NA 50% Rat Human +DTXSID6045082 Css NA 0.02553 mg/L PBTK NA 95% Rat Human +DTXSID6045084 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045084 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045084 Vd NA 0.6406 L/kg 1compartment NA NA Human Human DTXSID6045084 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045084 TK.Half.Life NA 6.971 hours 1compartment NA NA Human Human -DTXSID6045084 Css NA 1.317 mg/L 3compartmentss NA 50% Human Human -DTXSID6045084 Css NA 8.928 mg/L 3compartmentss NA 95% Human Human -DTXSID6045084 Css NA 1.033 mg/L PBTK NA 50% Human Human -DTXSID6045084 Css NA 5.614 mg/L PBTK NA 95% Human Human -DTXSID6045084 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045084 Fup NA 0.5662 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045084 Vd NA 0.6315 L/kg 1compartment NA NA Rat Human +DTXSID6045084 TK.Half.Life NA 7.954 hours 1compartment NA NA Human Human +DTXSID6045084 Css NA 1.152 mg/L 3compartmentss NA 50% Human Human +DTXSID6045084 Css NA 6.639 mg/L 3compartmentss NA 95% Human Human +DTXSID6045084 Css NA 0.9088 mg/L PBTK NA 50% Human Human +DTXSID6045084 Css NA 4.233 mg/L PBTK NA 95% Human Human +DTXSID6045084 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045084 Fup 0.521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045084 Vd NA 0.6558 L/kg 1compartment NA NA Rat Human DTXSID6045084 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045084 TK.Half.Life NA 2.459 hours 1compartment NA NA Rat Human -DTXSID6045084 Css NA 0.352 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045084 Css NA 2.225 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045084 Css NA 0.2634 mg/L PBTK NA 50% Rat Human -DTXSID6045084 Css NA 1.296 mg/L PBTK NA 95% Rat Human -DTXSID6045086 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045086 Fup NA 0.0627 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045086 Vd NA 0.9269 L/kg 1compartment NA NA Human Human -DTXSID6045086 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID6045086 TK.Half.Life NA 108.3 hours 1compartment NA NA Human Human -DTXSID6045086 Css NA 18.27 mg/L 3compartmentss NA 50% Human Human -DTXSID6045086 Css NA 76.55 mg/L 3compartmentss NA 95% Human Human -DTXSID6045086 Css NA 11.5 mg/L PBTK NA 50% Human Human -DTXSID6045086 Css NA 45.32 mg/L PBTK NA 95% Human Human -DTXSID6045086 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045086 Fup NA 0.0627 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045086 Vd NA 0.7166 L/kg 1compartment NA NA Rat Human -DTXSID6045086 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID6045086 TK.Half.Life NA 25.99 hours 1compartment NA NA Rat Human -DTXSID6045086 Css NA 5.133 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045086 Css NA 17.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045086 Css NA 3.021 mg/L PBTK NA 50% Rat Human -DTXSID6045086 Css NA 9.935 mg/L PBTK NA 95% Rat Human -DTXSID6045088 Clint NA 0.01939 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045088 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045088 Vd NA 1.759 L/kg 1compartment NA NA Human Human -DTXSID6045088 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6045088 TK.Half.Life NA 11.02 hours 1compartment NA NA Human Human -DTXSID6045088 Css NA 0.6648 mg/L 3compartmentss NA 50% Human Human -DTXSID6045088 Css NA 4.996 mg/L 3compartmentss NA 95% Human Human -DTXSID6045088 Css NA 0.6709 mg/L PBTK NA 50% Human Human -DTXSID6045088 Css NA 3.567 mg/L PBTK NA 95% Human Human -DTXSID6045088 Clint NA 0.01939 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045088 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045088 Vd NA 1.765 L/kg 1compartment NA NA Rat Human +DTXSID6045084 TK.Half.Life NA 2.775 hours 1compartment NA NA Rat Human +DTXSID6045084 Css NA 0.02172 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045084 Css NA 0.1602 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045084 Css NA 0.0166 mg/L PBTK NA 50% Rat Human +DTXSID6045084 Css NA 0.1031 mg/L PBTK NA 95% Rat Human +DTXSID6045086 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045086 Fup 0.0925 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045086 Vd NA 2.026 L/kg 1compartment NA NA Human Human +DTXSID6045086 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045086 TK.Half.Life NA 7.18 hours 1compartment NA NA Human Human +DTXSID6045086 Css NA 0.3998 mg/L 3compartmentss NA 50% Human Human +DTXSID6045086 Css NA 2.776 mg/L 3compartmentss NA 95% Human Human +DTXSID6045086 Css NA 0.2694 mg/L PBTK NA 50% Human Human +DTXSID6045086 Css NA 1.772 mg/L PBTK NA 95% Human Human +DTXSID6045086 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045086 Fup 0.0925 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045086 Vd NA 1.531 L/kg 1compartment NA NA Rat Human +DTXSID6045086 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6045086 TK.Half.Life NA 2.351 hours 1compartment NA NA Rat Human +DTXSID6045086 Css NA 0.05101 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045086 Css NA 0.3029 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045086 Css NA 0.03384 mg/L PBTK NA 50% Rat Human +DTXSID6045086 Css NA 0.1883 mg/L PBTK NA 95% Rat Human +DTXSID6045088 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045088 Fup 0.834 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045088 Vd NA 1.2 L/kg 1compartment NA NA Human Human +DTXSID6045088 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045088 TK.Half.Life NA 9.309 hours 1compartment NA NA Human Human +DTXSID6045088 Css NA 0.7614 mg/L 3compartmentss NA 50% Human Human +DTXSID6045088 Css NA 4.889 mg/L 3compartmentss NA 95% Human Human +DTXSID6045088 Css NA 0.6882 mg/L PBTK NA 50% Human Human +DTXSID6045088 Css NA 3.234 mg/L PBTK NA 95% Human Human +DTXSID6045088 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045088 Fup 0.834 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045088 Vd NA 1.217 L/kg 1compartment NA NA Rat Human DTXSID6045088 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045088 TK.Half.Life NA 3.832 hours 1compartment NA NA Rat Human -DTXSID6045088 Css NA 0.1696 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045088 Css NA 1.221 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045088 Css NA 0.1703 mg/L PBTK NA 50% Rat Human -DTXSID6045088 Css NA 0.7834 mg/L PBTK NA 95% Rat Human -DTXSID6045111 Clint NA 3.394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045111 Fup NA 0.221 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045111 Vd NA 0.6099 L/kg 1compartment NA NA Human Human -DTXSID6045111 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045111 TK.Half.Life NA 3.052 hours 1compartment NA NA Human Human -DTXSID6045111 Css NA 0.5578 mg/L 3compartmentss NA 50% Human Human -DTXSID6045111 Css NA 2.909 mg/L 3compartmentss NA 95% Human Human -DTXSID6045111 Css NA 0.3822 mg/L PBTK NA 50% Human Human -DTXSID6045111 Css NA 1.833 mg/L PBTK NA 95% Human Human -DTXSID6045111 Clint NA 3.394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045111 Fup NA 0.221 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045111 Vd NA 0.6003 L/kg 1compartment NA NA Rat Human -DTXSID6045111 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045111 TK.Half.Life NA 1.717 hours 1compartment NA NA Rat Human -DTXSID6045111 Css NA 0.2678 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045111 Css NA 1.037 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045111 Css NA 0.1758 mg/L PBTK NA 50% Rat Human -DTXSID6045111 Css NA 0.6136 mg/L PBTK NA 95% Rat Human -DTXSID6045115 Clint NA 8.032 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045115 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045115 Vd NA 0.2511 L/kg 1compartment NA NA Human Human +DTXSID6045088 TK.Half.Life NA 3.218 hours 1compartment NA NA Rat Human +DTXSID6045088 Css NA 0.01919 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045088 Css NA 0.1383 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045088 Css NA 0.01712 mg/L PBTK NA 50% Rat Human +DTXSID6045088 Css NA 0.09353 mg/L PBTK NA 95% Rat Human +DTXSID6045115 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045115 Fup 0.0606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045115 Vd NA 0.3079 L/kg 1compartment NA NA Human Human DTXSID6045115 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045115 TK.Half.Life NA 3.618 hours 1compartment NA NA Human Human -DTXSID6045115 Css NA 2.604 mg/L 3compartmentss NA 50% Human Human -DTXSID6045115 Css NA 19.59 mg/L 3compartmentss NA 95% Human Human -DTXSID6045115 Css NA 1.558 mg/L PBTK NA 50% Human Human -DTXSID6045115 Css NA 11.53 mg/L PBTK NA 95% Human Human -DTXSID6045115 Clint NA 8.032 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045115 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045115 Vd NA 0.2454 L/kg 1compartment NA NA Rat Human +DTXSID6045115 TK.Half.Life NA 3.132 hours 1compartment NA NA Human Human +DTXSID6045115 Css NA 1.463 mg/L 3compartmentss NA 50% Human Human +DTXSID6045115 Css NA 9.981 mg/L 3compartmentss NA 95% Human Human +DTXSID6045115 Css NA 0.8992 mg/L PBTK NA 50% Human Human +DTXSID6045115 Css NA 5.896 mg/L PBTK NA 95% Human Human +DTXSID6045115 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045115 Fup 0.0606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045115 Vd NA 0.3015 L/kg 1compartment NA NA Rat Human DTXSID6045115 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045115 TK.Half.Life NA 2.257 hours 1compartment NA NA Rat Human -DTXSID6045115 Css NA 1.426 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045115 Css NA 7.918 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045115 Css NA 0.7978 mg/L PBTK NA 50% Rat Human -DTXSID6045115 Css NA 4.322 mg/L PBTK NA 95% Rat Human -DTXSID6045117 Clint NA 22.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045117 Fup NA 0.041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045117 Vd NA 0.5562 L/kg 1compartment NA NA Human Human +DTXSID6045115 TK.Half.Life NA 1.907 hours 1compartment NA NA Rat Human +DTXSID6045115 Css NA 0.0656 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045115 Css NA 0.5328 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045115 Css NA 0.03888 mg/L PBTK NA 50% Rat Human +DTXSID6045115 Css NA 0.3052 mg/L PBTK NA 95% Rat Human +DTXSID6045117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045117 Fup 0.0306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045117 Vd NA 0.536 L/kg 1compartment NA NA Human Human DTXSID6045117 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045117 TK.Half.Life NA 2.727 hours 1compartment NA NA Human Human -DTXSID6045117 Css NA 0.7599 mg/L 3compartmentss NA 50% Human Human -DTXSID6045117 Css NA 6.978 mg/L 3compartmentss NA 95% Human Human -DTXSID6045117 Css NA 0.4648 mg/L PBTK NA 50% Human Human -DTXSID6045117 Css NA 4.121 mg/L PBTK NA 95% Human Human -DTXSID6045117 Clint NA 22.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045117 Fup NA 0.041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045117 Vd NA 0.4419 L/kg 1compartment NA NA Rat Human +DTXSID6045117 TK.Half.Life NA 3.378 hours 1compartment NA NA Human Human +DTXSID6045117 Css NA 0.9857 mg/L 3compartmentss NA 50% Human Human +DTXSID6045117 Css NA 9.464 mg/L 3compartmentss NA 95% Human Human +DTXSID6045117 Css NA 0.5968 mg/L PBTK NA 50% Human Human +DTXSID6045117 Css NA 5.619 mg/L PBTK NA 95% Human Human +DTXSID6045117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045117 Fup 0.0306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045117 Vd NA 0.4219 L/kg 1compartment NA NA Rat Human DTXSID6045117 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045117 TK.Half.Life NA 1.338 hours 1compartment NA NA Rat Human -DTXSID6045117 Css NA 0.4253 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045117 Css NA 3.063 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045117 Css NA 0.2424 mg/L PBTK NA 50% Rat Human -DTXSID6045117 Css NA 1.708 mg/L PBTK NA 95% Rat Human -DTXSID6045119 Clint NA 6.634 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045119 Fup NA 0.0987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045119 Vd NA 2.711 L/kg 1compartment NA NA Human Human -DTXSID6045119 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID6045119 TK.Half.Life NA 40.68 hours 1compartment NA NA Human Human -DTXSID6045119 Css NA 1.93 mg/L 3compartmentss NA 50% Human Human -DTXSID6045119 Css NA 10.75 mg/L 3compartmentss NA 95% Human Human -DTXSID6045119 Css NA 1.344 mg/L PBTK NA 50% Human Human -DTXSID6045119 Css NA 7.197 mg/L PBTK NA 95% Human Human -DTXSID6045119 Clint NA 6.634 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045119 Fup NA 0.0987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045119 Vd NA 2.052 L/kg 1compartment NA NA Rat Human -DTXSID6045119 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6045119 TK.Half.Life NA 8.753 hours 1compartment NA NA Rat Human -DTXSID6045119 Css NA 1.036 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045119 Css NA 4.107 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045119 Css NA 0.6872 mg/L PBTK NA 50% Rat Human -DTXSID6045119 Css NA 2.607 mg/L PBTK NA 95% Rat Human -DTXSID6045161 Clint NA 66.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045161 Fup NA 0.5765 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045161 Vd NA 2.081 L/kg 1compartment NA NA Human Human +DTXSID6045117 TK.Half.Life NA 1.669 hours 1compartment NA NA Rat Human +DTXSID6045117 Css NA 0.1288 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045117 Css NA 0.9856 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045117 Css NA 0.0754 mg/L PBTK NA 50% Rat Human +DTXSID6045117 Css NA 0.5646 mg/L PBTK NA 95% Rat Human +DTXSID6045119 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045119 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045119 Vd NA 3.095 L/kg 1compartment NA NA Human Human +DTXSID6045119 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6045119 TK.Half.Life NA 20.49 hours 1compartment NA NA Human Human +DTXSID6045119 Css NA 0.6906 mg/L 3compartmentss NA 50% Human Human +DTXSID6045119 Css NA 4.359 mg/L 3compartmentss NA 95% Human Human +DTXSID6045119 Css NA 0.4968 mg/L PBTK NA 50% Human Human +DTXSID6045119 Css NA 2.984 mg/L PBTK NA 95% Human Human +DTXSID6045119 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045119 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045119 Vd NA 2.34 L/kg 1compartment NA NA Rat Human +DTXSID6045119 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6045119 TK.Half.Life NA 3.386 hours 1compartment NA NA Rat Human +DTXSID6045119 Css NA 0.08709 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045119 Css NA 0.4497 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045119 Css NA 0.06212 mg/L PBTK NA 50% Rat Human +DTXSID6045119 Css NA 0.309 mg/L PBTK NA 95% Rat Human +DTXSID6045161 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045161 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045161 Vd NA 1.552 L/kg 1compartment NA NA Human Human DTXSID6045161 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045161 TK.Half.Life NA 1.193 hours 1compartment NA NA Human Human -DTXSID6045161 Css NA 0.009208 mg/L 3compartmentss NA 50% Human Human -DTXSID6045161 Css NA 0.1113 mg/L 3compartmentss NA 95% Human Human -DTXSID6045161 Css NA 0.00964 mg/L PBTK NA 50% Human Human -DTXSID6045161 Css NA 0.08923 mg/L PBTK NA 95% Human Human -DTXSID6045161 Clint NA 66.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045161 Fup NA 0.5765 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045161 Vd NA 2.053 L/kg 1compartment NA NA Rat Human +DTXSID6045161 TK.Half.Life NA 3.023 hours 1compartment NA NA Human Human +DTXSID6045161 Css NA 0.1335 mg/L 3compartmentss NA 50% Human Human +DTXSID6045161 Css NA 0.9966 mg/L 3compartmentss NA 95% Human Human +DTXSID6045161 Css NA 0.1225 mg/L PBTK NA 50% Human Human +DTXSID6045161 Css NA 0.7427 mg/L PBTK NA 95% Human Human +DTXSID6045161 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045161 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045161 Vd NA 1.524 L/kg 1compartment NA NA Rat Human DTXSID6045161 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045161 TK.Half.Life NA 0.5554 hours 1compartment NA NA Rat Human -DTXSID6045161 Css NA 0.00478 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045161 Css NA 0.05429 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045161 Css NA 0.004957 mg/L PBTK NA 50% Rat Human -DTXSID6045161 Css NA 0.03916 mg/L PBTK NA 95% Rat Human -DTXSID6045163 Clint NA 66.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045163 Fup NA 0.0122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045163 Vd NA 2.638 L/kg 1compartment NA NA Human Human -DTXSID6045163 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6045163 TK.Half.Life NA 16.41 hours 1compartment NA NA Human Human -DTXSID6045163 Css NA 0.7966 mg/L 3compartmentss NA 50% Human Human -DTXSID6045163 Css NA 5.896 mg/L 3compartmentss NA 95% Human Human -DTXSID6045163 Css NA 0.533 mg/L PBTK NA 50% Human Human -DTXSID6045163 Css NA 3.791 mg/L PBTK NA 95% Human Human -DTXSID6045163 Clint NA 66.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045163 Fup NA 0.0122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045163 Vd NA 1.968 L/kg 1compartment NA NA Rat Human -DTXSID6045163 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045163 TK.Half.Life NA 3.823 hours 1compartment NA NA Rat Human -DTXSID6045163 Css NA 0.4514 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045163 Css NA 2.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045163 Css NA 0.284 mg/L PBTK NA 50% Rat Human -DTXSID6045163 Css NA 1.652 mg/L PBTK NA 95% Rat Human +DTXSID6045161 TK.Half.Life NA 1.703 hours 1compartment NA NA Rat Human +DTXSID6045161 Css NA 0.01548 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045161 Css NA 0.08674 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045161 Css NA 0.01442 mg/L PBTK NA 50% Rat Human +DTXSID6045161 Css NA 0.06232 mg/L PBTK NA 95% Rat Human +DTXSID6045163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045163 Fup 0.00965 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045163 Vd NA 2.567 L/kg 1compartment NA NA Human Human +DTXSID6045163 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID6045163 TK.Half.Life NA 47.28 hours 1compartment NA NA Human Human +DTXSID6045163 Css NA 2.574 mg/L 3compartmentss NA 50% Human Human +DTXSID6045163 Css NA 19.16 mg/L 3compartmentss NA 95% Human Human +DTXSID6045163 Css NA 1.7 mg/L PBTK NA 50% Human Human +DTXSID6045163 Css NA 12.26 mg/L PBTK NA 95% Human Human +DTXSID6045163 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045163 Fup 0.00965 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045163 Vd NA 1.912 L/kg 1compartment NA NA Rat Human +DTXSID6045163 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6045163 TK.Half.Life NA 11.05 hours 1compartment NA NA Rat Human +DTXSID6045163 Css NA 0.3363 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045163 Css NA 2.086 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045163 Css NA 0.2182 mg/L PBTK NA 50% Rat Human +DTXSID6045163 Css NA 1.307 mg/L PBTK NA 95% Rat Human DTXSID6045165 Clint 13.8 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID6045165 Fup NA 0.0253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045165 Vd NA 3.011 L/kg 1compartment NA NA Human Human -DTXSID6045165 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6045165 TK.Half.Life NA 39.77 hours 1compartment NA NA Human Human -DTXSID6045165 Css NA 1.67 mg/L 3compartmentss NA 50% Human Human -DTXSID6045165 Css NA 10.59 mg/L 3compartmentss NA 95% Human Human -DTXSID6045165 Css NA 1.163 mg/L PBTK NA 50% Human Human -DTXSID6045165 Css NA 7.091 mg/L PBTK NA 95% Human Human +DTXSID6045165 Fup 0.0458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045165 Vd NA 1.028 L/kg 1compartment NA NA Human Human +DTXSID6045165 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045165 TK.Half.Life NA 6.33 hours 1compartment NA NA Human Human +DTXSID6045165 Css NA 0.8917 mg/L 3compartmentss NA 50% Human Human +DTXSID6045165 Css NA 6.919 mg/L 3compartmentss NA 95% Human Human +DTXSID6045165 Css NA 0.5765 mg/L PBTK NA 50% Human Human +DTXSID6045165 Css NA 4.216 mg/L PBTK NA 95% Human Human DTXSID6045165 Clint 13.8 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID6045165 Fup NA 0.0253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045165 Vd NA 2.245 L/kg 1compartment NA NA Rat Human -DTXSID6045165 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6045165 TK.Half.Life NA 7.692 hours 1compartment NA NA Rat Human -DTXSID6045165 Css NA 0.9754 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045165 Css NA 5.419 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045165 Css NA 0.643 mg/L PBTK NA 50% Rat Human -DTXSID6045165 Css NA 3.505 mg/L PBTK NA 95% Rat Human -DTXSID6045167 Clint NA 36.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6045165 Fup 0.0458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045165 Vd NA 0.5725 L/kg 1compartment NA NA Rat Human +DTXSID6045165 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6045165 TK.Half.Life NA 4.741 hours 1compartment NA NA Rat Human +DTXSID6045165 Css NA 0.2713 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045165 Css NA 2.131 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045165 Css NA 0.1607 mg/L PBTK NA 50% Rat Human +DTXSID6045165 Css NA 1.218 mg/L PBTK NA 95% Rat Human +DTXSID6045167 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6045167 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6045167 Vd NA 0.3665 L/kg 1compartment NA NA Human Human +DTXSID6045167 Vd NA 0.4057 L/kg 1compartment NA NA Human Human DTXSID6045167 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045167 TK.Half.Life NA 1.081 hours 1compartment NA NA Human Human -DTXSID6045167 Css NA 0.3789 mg/L 3compartmentss NA 50% Human Human -DTXSID6045167 Css NA 3.205 mg/L 3compartmentss NA 95% Human Human -DTXSID6045167 Css NA 0.227 mg/L PBTK NA 50% Human Human -DTXSID6045167 Css NA 1.863 mg/L PBTK NA 95% Human Human -DTXSID6045167 Clint NA 36.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6045167 TK.Half.Life NA 4.82 hours 1compartment NA NA Human Human +DTXSID6045167 Css NA 1.95 mg/L 3compartmentss NA 50% Human Human +DTXSID6045167 Css NA 13.98 mg/L 3compartmentss NA 95% Human Human +DTXSID6045167 Css NA 1.179 mg/L PBTK NA 50% Human Human +DTXSID6045167 Css NA 8.144 mg/L PBTK NA 95% Human Human +DTXSID6045167 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6045167 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6045167 Vd NA 0.3121 L/kg 1compartment NA NA Rat Human +DTXSID6045167 Vd NA 0.3384 L/kg 1compartment NA NA Rat Human DTXSID6045167 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045167 TK.Half.Life NA 0.5554 hours 1compartment NA NA Rat Human -DTXSID6045167 Css NA 0.2142 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045167 Css NA 1.537 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045167 Css NA 0.1205 mg/L PBTK NA 50% Rat Human -DTXSID6045167 Css NA 0.8419 mg/L PBTK NA 95% Rat Human +DTXSID6045167 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human +DTXSID6045167 Css NA 0.2416 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045167 Css NA 1.327 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045167 Css NA 0.1412 mg/L PBTK NA 50% Rat Human +DTXSID6045167 Css NA 0.751 mg/L PBTK NA 95% Rat Human DTXSID6045169 Clint 2.57 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6045169 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6045169 Vd NA 3.194 L/kg 1compartment NA NA Human Human DTXSID6045169 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID6045169 TK.Half.Life NA 7.023 hours 1compartment NA NA Human Human -DTXSID6045169 Css NA 0.188 mg/L 3compartmentss NA 50% Human Human -DTXSID6045169 Css NA 1.635 mg/L 3compartmentss NA 95% Human Human -DTXSID6045169 Css NA 0.1757 mg/L PBTK NA 50% Human Human -DTXSID6045169 Css NA 1.121 mg/L PBTK NA 95% Human Human +DTXSID6045169 Css NA 0.1754 mg/L 3compartmentss NA 50% Human Human +DTXSID6045169 Css NA 1.195 mg/L 3compartmentss NA 95% Human Human +DTXSID6045169 Css NA 0.1675 mg/L PBTK NA 50% Human Human +DTXSID6045169 Css NA 1.146 mg/L PBTK NA 95% Human Human DTXSID6045169 Clint 2.57 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID6045169 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6045169 Vd NA 3.161 L/kg 1compartment NA NA Rat Human DTXSID6045169 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID6045169 TK.Half.Life NA 3.794 hours 1compartment NA NA Rat Human -DTXSID6045169 Css NA 0.08425 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045169 Css NA 0.6787 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045169 Css NA 0.07664 mg/L PBTK NA 50% Rat Human -DTXSID6045169 Css NA 0.4267 mg/L PBTK NA 95% Rat Human -DTXSID6045240 Clint NA 1.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045240 Fup NA 0.86 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045240 Vd NA 22.92 L/kg 1compartment NA NA Human Human -DTXSID6045240 Days.Css NA 84 Days PBTK NA NA Human Human -DTXSID6045240 TK.Half.Life NA 392.7 hours 1compartment NA NA Human Human -DTXSID6045240 Css NA 0.5882 mg/L 3compartmentss NA 50% Human Human -DTXSID6045240 Css NA 4.467 mg/L 3compartmentss NA 95% Human Human -DTXSID6045240 Css NA 1.46 mg/L PBTK NA 50% Human Human -DTXSID6045240 Css NA 8.698 mg/L PBTK NA 95% Human Human -DTXSID6045240 Clint NA 1.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045240 Fup NA 0.86 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045240 Vd NA 18.85 L/kg 1compartment NA NA Rat Human -DTXSID6045240 Days.Css NA 52 Days PBTK NA NA Rat Human -DTXSID6045240 TK.Half.Life NA 55.27 hours 1compartment NA NA Rat Human -DTXSID6045240 Css NA 0.2944 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045240 Css NA 1.989 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045240 Css NA 0.7741 mg/L PBTK NA 50% Rat Human -DTXSID6045240 Css NA 4.031 mg/L PBTK NA 95% Rat Human -DTXSID6045244 Clint NA 1.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045244 Fup NA 0.4913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045244 Vd NA 0.4488 L/kg 1compartment NA NA Human Human +DTXSID6045169 Css NA 0.01784 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045169 Css NA 0.09906 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045169 Css NA 0.01773 mg/L PBTK NA 50% Rat Human +DTXSID6045169 Css NA 0.0985 mg/L PBTK NA 95% Rat Human +DTXSID6045244 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045244 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045244 Vd NA 0.4364 L/kg 1compartment NA NA Human Human DTXSID6045244 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045244 TK.Half.Life NA 1.652 hours 1compartment NA NA Human Human -DTXSID6045244 Css NA 0.3958 mg/L 3compartmentss NA 50% Human Human -DTXSID6045244 Css NA 2.464 mg/L 3compartmentss NA 95% Human Human -DTXSID6045244 Css NA 0.2876 mg/L PBTK NA 50% Human Human -DTXSID6045244 Css NA 1.521 mg/L PBTK NA 95% Human Human -DTXSID6045244 Clint NA 1.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045244 Fup NA 0.4913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045244 Vd NA 0.4544 L/kg 1compartment NA NA Rat Human +DTXSID6045244 TK.Half.Life NA 6.075 hours 1compartment NA NA Human Human +DTXSID6045244 Css NA 1.582 mg/L 3compartmentss NA 50% Human Human +DTXSID6045244 Css NA 7.366 mg/L 3compartmentss NA 95% Human Human +DTXSID6045244 Css NA 1.145 mg/L PBTK NA 50% Human Human +DTXSID6045244 Css NA 4.618 mg/L PBTK NA 95% Human Human +DTXSID6045244 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045244 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045244 Vd NA 0.4414 L/kg 1compartment NA NA Rat Human DTXSID6045244 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045244 TK.Half.Life NA 0.8764 hours 1compartment NA NA Rat Human -DTXSID6045244 Css NA 0.1703 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045244 Css NA 0.8617 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045244 Css NA 0.1192 mg/L PBTK NA 50% Rat Human -DTXSID6045244 Css NA 0.5044 mg/L PBTK NA 95% Rat Human -DTXSID6045248 Clint NA 51.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045248 Fup NA 0.2786 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045248 Vd NA 3.876 L/kg 1compartment NA NA Human Human +DTXSID6045244 TK.Half.Life NA 2.093 hours 1compartment NA NA Rat Human +DTXSID6045244 Css NA 0.09962 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045244 Css NA 0.4035 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045244 Css NA 0.07084 mg/L PBTK NA 50% Rat Human +DTXSID6045244 Css NA 0.2437 mg/L PBTK NA 95% Rat Human +DTXSID6045248 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045248 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045248 Vd NA 0.9549 L/kg 1compartment NA NA Human Human DTXSID6045248 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045248 TK.Half.Life NA 2.318 hours 1compartment NA NA Human Human -DTXSID6045248 Css NA 0.01382 mg/L 3compartmentss NA 50% Human Human -DTXSID6045248 Css NA 0.1259 mg/L 3compartmentss NA 95% Human Human -DTXSID6045248 Css NA 0.01801 mg/L PBTK NA 50% Human Human -DTXSID6045248 Css NA 0.133 mg/L PBTK NA 95% Human Human -DTXSID6045248 Clint NA 51.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045248 Fup NA 0.2786 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045248 Vd NA 3.911 L/kg 1compartment NA NA Rat Human +DTXSID6045248 TK.Half.Life NA 1.603 hours 1compartment NA NA Human Human +DTXSID6045248 Css NA 0.1046 mg/L 3compartmentss NA 50% Human Human +DTXSID6045248 Css NA 0.8761 mg/L 3compartmentss NA 95% Human Human +DTXSID6045248 Css NA 0.08571 mg/L PBTK NA 50% Human Human +DTXSID6045248 Css NA 0.5962 mg/L PBTK NA 95% Human Human +DTXSID6045248 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045248 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045248 Vd NA 0.9741 L/kg 1compartment NA NA Rat Human DTXSID6045248 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045248 TK.Half.Life NA 1.202 hours 1compartment NA NA Rat Human -DTXSID6045248 Css NA 0.007063 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045248 Css NA 0.05513 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045248 Css NA 0.009362 mg/L PBTK NA 50% Rat Human -DTXSID6045248 Css NA 0.05457 mg/L PBTK NA 95% Rat Human -DTXSID6045292 Clint NA 39.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045292 Fup NA 0.0629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045292 Vd NA 1.962 L/kg 1compartment NA NA Human Human +DTXSID6045248 TK.Half.Life NA 0.9055 hours 1compartment NA NA Rat Human +DTXSID6045248 Css NA 0.00453 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045248 Css NA 0.04232 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045248 Css NA 0.0038 mg/L PBTK NA 50% Rat Human +DTXSID6045248 Css NA 0.02882 mg/L PBTK NA 95% Rat Human +DTXSID6045292 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045292 Fup 0.0998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045292 Vd NA 2.424 L/kg 1compartment NA NA Human Human DTXSID6045292 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045292 TK.Half.Life NA 4.489 hours 1compartment NA NA Human Human -DTXSID6045292 Css NA 0.2313 mg/L 3compartmentss NA 50% Human Human -DTXSID6045292 Css NA 1.772 mg/L 3compartmentss NA 95% Human Human -DTXSID6045292 Css NA 0.1614 mg/L PBTK NA 50% Human Human -DTXSID6045292 Css NA 1.153 mg/L PBTK NA 95% Human Human -DTXSID6045292 Clint NA 39.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045292 Fup NA 0.0629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045292 Vd NA 1.65 L/kg 1compartment NA NA Rat Human +DTXSID6045292 TK.Half.Life NA 6.545 hours 1compartment NA NA Human Human +DTXSID6045292 Css NA 0.2646 mg/L 3compartmentss NA 50% Human Human +DTXSID6045292 Css NA 2.038 mg/L 3compartmentss NA 95% Human Human +DTXSID6045292 Css NA 0.1966 mg/L PBTK NA 50% Human Human +DTXSID6045292 Css NA 1.375 mg/L PBTK NA 95% Human Human +DTXSID6045292 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045292 Fup 0.0998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045292 Vd NA 2.052 L/kg 1compartment NA NA Rat Human DTXSID6045292 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045292 TK.Half.Life NA 1.919 hours 1compartment NA NA Rat Human -DTXSID6045292 Css NA 0.1298 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045292 Css NA 0.8154 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045292 Css NA 0.08656 mg/L PBTK NA 50% Rat Human -DTXSID6045292 Css NA 0.4986 mg/L PBTK NA 95% Rat Human -DTXSID6045296 Clint NA 11.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045296 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045296 Vd NA 2.572 L/kg 1compartment NA NA Human Human -DTXSID6045296 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045296 TK.Half.Life NA 1.757 hours 1compartment NA NA Human Human -DTXSID6045296 Css NA 0.03273 mg/L 3compartmentss NA 50% Human Human -DTXSID6045296 Css NA 0.3854 mg/L 3compartmentss NA 95% Human Human -DTXSID6045296 Css NA 0.03549 mg/L PBTK NA 50% Human Human -DTXSID6045296 Css NA 0.3407 mg/L PBTK NA 95% Human Human -DTXSID6045296 Clint NA 11.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045296 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045296 Vd NA 2.62 L/kg 1compartment NA NA Rat Human +DTXSID6045292 TK.Half.Life NA 2.612 hours 1compartment NA NA Rat Human +DTXSID6045292 Css NA 0.03326 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045292 Css NA 0.2136 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045292 Css NA 0.02479 mg/L PBTK NA 50% Rat Human +DTXSID6045292 Css NA 0.145 mg/L PBTK NA 95% Rat Human +DTXSID6045296 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045296 Fup 0.64 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045296 Vd NA 1.455 L/kg 1compartment NA NA Human Human +DTXSID6045296 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6045296 TK.Half.Life NA 14.71 hours 1compartment NA NA Human Human +DTXSID6045296 Css NA 0.9838 mg/L 3compartmentss NA 50% Human Human +DTXSID6045296 Css NA 7.359 mg/L 3compartmentss NA 95% Human Human +DTXSID6045296 Css NA 0.9014 mg/L PBTK NA 50% Human Human +DTXSID6045296 Css NA 4.757 mg/L PBTK NA 95% Human Human +DTXSID6045296 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045296 Fup 0.64 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045296 Vd NA 1.481 L/kg 1compartment NA NA Rat Human DTXSID6045296 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045296 TK.Half.Life NA 0.927 hours 1compartment NA NA Rat Human -DTXSID6045296 Css NA 0.01577 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045296 Css NA 0.1505 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045296 Css NA 0.01745 mg/L PBTK NA 50% Rat Human -DTXSID6045296 Css NA 0.1168 mg/L PBTK NA 95% Rat Human -DTXSID6045321 Clint NA 131.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045321 Fup NA 0.1943 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045321 Vd NA 1.78 L/kg 1compartment NA NA Human Human +DTXSID6045296 TK.Half.Life NA 5.1 hours 1compartment NA NA Rat Human +DTXSID6045296 Css NA 0.05909 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045296 Css NA 0.3937 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045296 Css NA 0.0549 mg/L PBTK NA 50% Rat Human +DTXSID6045296 Css NA 0.252 mg/L PBTK NA 95% Rat Human +DTXSID6045321 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045321 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045321 Vd NA 1.445 L/kg 1compartment NA NA Human Human DTXSID6045321 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045321 TK.Half.Life NA 1.615 hours 1compartment NA NA Human Human -DTXSID6045321 Css NA 0.02105 mg/L 3compartmentss NA 50% Human Human -DTXSID6045321 Css NA 0.1496 mg/L 3compartmentss NA 95% Human Human -DTXSID6045321 Css NA 0.01592 mg/L PBTK NA 50% Human Human -DTXSID6045321 Css NA 0.1053 mg/L PBTK NA 95% Human Human -DTXSID6045321 Clint NA 131.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045321 Fup NA 0.1943 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045321 Vd NA 1.497 L/kg 1compartment NA NA Rat Human +DTXSID6045321 TK.Half.Life NA 2.077 hours 1compartment NA NA Human Human +DTXSID6045321 Css NA 0.08232 mg/L 3compartmentss NA 50% Human Human +DTXSID6045321 Css NA 0.6181 mg/L 3compartmentss NA 95% Human Human +DTXSID6045321 Css NA 0.06308 mg/L PBTK NA 50% Human Human +DTXSID6045321 Css NA 0.4326 mg/L PBTK NA 95% Human Human +DTXSID6045321 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045321 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045321 Vd NA 1.285 L/kg 1compartment NA NA Rat Human DTXSID6045321 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045321 TK.Half.Life NA 0.6233 hours 1compartment NA NA Rat Human -DTXSID6045321 Css NA 0.01156 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045321 Css NA 0.06637 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045321 Css NA 0.00842 mg/L PBTK NA 50% Rat Human -DTXSID6045321 Css NA 0.04539 mg/L PBTK NA 95% Rat Human -DTXSID6045323 Clint NA 14.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045323 Fup NA 0.1814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045323 Vd NA 3.216 L/kg 1compartment NA NA Human Human -DTXSID6045323 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6045323 TK.Half.Life NA 14.85 hours 1compartment NA NA Human Human -DTXSID6045323 Css NA 0.4448 mg/L 3compartmentss NA 50% Human Human -DTXSID6045323 Css NA 2.693 mg/L 3compartmentss NA 95% Human Human -DTXSID6045323 Css NA 0.3454 mg/L PBTK NA 50% Human Human -DTXSID6045323 Css NA 1.979 mg/L PBTK NA 95% Human Human -DTXSID6045323 Clint NA 14.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045323 Fup NA 0.1814 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045323 Vd NA 2.581 L/kg 1compartment NA NA Rat Human +DTXSID6045321 TK.Half.Life NA 0.9686 hours 1compartment NA NA Rat Human +DTXSID6045321 Css NA 0.01032 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045321 Css NA 0.05717 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045321 Css NA 0.007909 mg/L PBTK NA 50% Rat Human +DTXSID6045321 Css NA 0.03949 mg/L PBTK NA 95% Rat Human +DTXSID6045323 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045323 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045323 Vd NA 3.096 L/kg 1compartment NA NA Human Human +DTXSID6045323 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045323 TK.Half.Life NA 5.536 hours 1compartment NA NA Human Human +DTXSID6045323 Css NA 0.1174 mg/L 3compartmentss NA 50% Human Human +DTXSID6045323 Css NA 0.7881 mg/L 3compartmentss NA 95% Human Human +DTXSID6045323 Css NA 0.101 mg/L PBTK NA 50% Human Human +DTXSID6045323 Css NA 0.6201 mg/L PBTK NA 95% Human Human +DTXSID6045323 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045323 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045323 Vd NA 2.658 L/kg 1compartment NA NA Rat Human DTXSID6045323 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045323 TK.Half.Life NA 3.454 hours 1compartment NA NA Rat Human -DTXSID6045323 Css NA 0.2394 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045323 Css NA 1.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045323 Css NA 0.1799 mg/L PBTK NA 50% Rat Human -DTXSID6045323 Css NA 0.8292 mg/L PBTK NA 95% Rat Human -DTXSID6045325 Clint NA 47.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045325 Fup NA 0.277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045325 Vd NA 2.536 L/kg 1compartment NA NA Human Human +DTXSID6045323 TK.Half.Life NA 1.956 hours 1compartment NA NA Rat Human +DTXSID6045323 Css NA 0.01438 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045323 Css NA 0.07522 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045323 Css NA 0.01254 mg/L PBTK NA 50% Rat Human +DTXSID6045323 Css NA 0.06098 mg/L PBTK NA 95% Rat Human +DTXSID6045325 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045325 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045325 Vd NA 3.84 L/kg 1compartment NA NA Human Human DTXSID6045325 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045325 TK.Half.Life NA 2.062 hours 1compartment NA NA Human Human -DTXSID6045325 Css NA 0.02536 mg/L 3compartmentss NA 50% Human Human -DTXSID6045325 Css NA 0.2064 mg/L 3compartmentss NA 95% Human Human -DTXSID6045325 Css NA 0.02494 mg/L PBTK NA 50% Human Human -DTXSID6045325 Css NA 0.1724 mg/L PBTK NA 95% Human Human -DTXSID6045325 Clint NA 47.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045325 Fup NA 0.277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045325 Vd NA 2.553 L/kg 1compartment NA NA Rat Human +DTXSID6045325 TK.Half.Life NA 5.909 hours 1compartment NA NA Human Human +DTXSID6045325 Css NA 0.08186 mg/L 3compartmentss NA 50% Human Human +DTXSID6045325 Css NA 0.6999 mg/L 3compartmentss NA 95% Human Human +DTXSID6045325 Css NA 0.1032 mg/L PBTK NA 50% Human Human +DTXSID6045325 Css NA 0.6351 mg/L PBTK NA 95% Human Human +DTXSID6045325 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045325 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045325 Vd NA 3.895 L/kg 1compartment NA NA Rat Human DTXSID6045325 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045325 TK.Half.Life NA 1.065 hours 1compartment NA NA Rat Human -DTXSID6045325 Css NA 0.0135 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045325 Css NA 0.09212 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045325 Css NA 0.01302 mg/L PBTK NA 50% Rat Human -DTXSID6045325 Css NA 0.07223 mg/L PBTK NA 95% Rat Human -DTXSID6045371 Clint NA 40.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045371 Fup NA 0.0775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045371 Vd NA 1.705 L/kg 1compartment NA NA Human Human +DTXSID6045325 TK.Half.Life NA 3.383 hours 1compartment NA NA Rat Human +DTXSID6045325 Css NA 0.009154 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045325 Css NA 0.06693 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045325 Css NA 0.01209 mg/L PBTK NA 50% Rat Human +DTXSID6045325 Css NA 0.05663 mg/L PBTK NA 95% Rat Human +DTXSID6045371 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045371 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045371 Vd NA 2.178 L/kg 1compartment NA NA Human Human DTXSID6045371 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045371 TK.Half.Life NA 3.972 hours 1compartment NA NA Human Human -DTXSID6045371 Css NA 0.2377 mg/L 3compartmentss NA 50% Human Human -DTXSID6045371 Css NA 1.8 mg/L 3compartmentss NA 95% Human Human -DTXSID6045371 Css NA 0.1563 mg/L PBTK NA 50% Human Human -DTXSID6045371 Css NA 1.125 mg/L PBTK NA 95% Human Human -DTXSID6045371 Clint NA 40.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045371 Fup NA 0.0775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045371 Vd NA 1.289 L/kg 1compartment NA NA Rat Human +DTXSID6045371 TK.Half.Life NA 7.814 hours 1compartment NA NA Human Human +DTXSID6045371 Css NA 0.3971 mg/L 3compartmentss NA 50% Human Human +DTXSID6045371 Css NA 2.823 mg/L 3compartmentss NA 95% Human Human +DTXSID6045371 Css NA 0.2704 mg/L PBTK NA 50% Human Human +DTXSID6045371 Css NA 1.846 mg/L PBTK NA 95% Human Human +DTXSID6045371 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045371 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045371 Vd NA 1.646 L/kg 1compartment NA NA Rat Human DTXSID6045371 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045371 TK.Half.Life NA 1.434 hours 1compartment NA NA Rat Human -DTXSID6045371 Css NA 0.1337 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045371 Css NA 0.7971 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045371 Css NA 0.08308 mg/L PBTK NA 50% Rat Human -DTXSID6045371 Css NA 0.4744 mg/L PBTK NA 95% Rat Human -DTXSID6045373 Clint NA 48.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045373 Fup NA 0.079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045373 Vd NA 2.968 L/kg 1compartment NA NA Human Human +DTXSID6045371 TK.Half.Life NA 2.418 hours 1compartment NA NA Rat Human +DTXSID6045371 Css NA 0.0502 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045371 Css NA 0.2892 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045371 Css NA 0.03367 mg/L PBTK NA 50% Rat Human +DTXSID6045371 Css NA 0.1839 mg/L PBTK NA 95% Rat Human +DTXSID6045373 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045373 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045373 Vd NA 2.713 L/kg 1compartment NA NA Human Human DTXSID6045373 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045373 TK.Half.Life NA 14.42 hours 1compartment NA NA Human Human -DTXSID6045373 Css NA 0.5289 mg/L 3compartmentss NA 50% Human Human -DTXSID6045373 Css NA 3.298 mg/L 3compartmentss NA 95% Human Human -DTXSID6045373 Css NA 0.3688 mg/L PBTK NA 50% Human Human -DTXSID6045373 Css NA 2.255 mg/L PBTK NA 95% Human Human -DTXSID6045373 Clint NA 48.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045373 Fup NA 0.079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045373 Vd NA 2.234 L/kg 1compartment NA NA Rat Human +DTXSID6045373 TK.Half.Life NA 8.63 hours 1compartment NA NA Human Human +DTXSID6045373 Css NA 0.2864 mg/L 3compartmentss NA 50% Human Human +DTXSID6045373 Css NA 1.753 mg/L 3compartmentss NA 95% Human Human +DTXSID6045373 Css NA 0.2069 mg/L PBTK NA 50% Human Human +DTXSID6045373 Css NA 1.208 mg/L PBTK NA 95% Human Human +DTXSID6045373 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045373 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045373 Vd NA 2.077 L/kg 1compartment NA NA Rat Human DTXSID6045373 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045373 TK.Half.Life NA 2.762 hours 1compartment NA NA Rat Human -DTXSID6045373 Css NA 0.2964 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045373 Css NA 1.578 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045373 Css NA 0.1972 mg/L PBTK NA 50% Rat Human -DTXSID6045373 Css NA 1.021 mg/L PBTK NA 95% Rat Human -DTXSID6045375 Clint NA 36.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045375 Fup NA 0.0503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045375 Vd NA 2.031 L/kg 1compartment NA NA Human Human +DTXSID6045373 TK.Half.Life NA 2.182 hours 1compartment NA NA Rat Human +DTXSID6045373 Css NA 0.03582 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045373 Css NA 0.1714 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045373 Css NA 0.02607 mg/L PBTK NA 50% Rat Human +DTXSID6045373 Css NA 0.1183 mg/L PBTK NA 95% Rat Human +DTXSID6045375 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045375 Fup 0.0961 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045375 Vd NA 2.411 L/kg 1compartment NA NA Human Human DTXSID6045375 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045375 TK.Half.Life NA 7.276 hours 1compartment NA NA Human Human -DTXSID6045375 Css NA 0.4359 mg/L 3compartmentss NA 50% Human Human -DTXSID6045375 Css NA 3.244 mg/L 3compartmentss NA 95% Human Human -DTXSID6045375 Css NA 0.2864 mg/L PBTK NA 50% Human Human -DTXSID6045375 Css NA 2.046 mg/L PBTK NA 95% Human Human -DTXSID6045375 Clint NA 36.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045375 Fup NA 0.0503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045375 Vd NA 1.524 L/kg 1compartment NA NA Rat Human +DTXSID6045375 TK.Half.Life NA 10.16 hours 1compartment NA NA Human Human +DTXSID6045375 Css NA 0.4737 mg/L 3compartmentss NA 50% Human Human +DTXSID6045375 Css NA 3.209 mg/L 3compartmentss NA 95% Human Human +DTXSID6045375 Css NA 0.3234 mg/L PBTK NA 50% Human Human +DTXSID6045375 Css NA 2.109 mg/L PBTK NA 95% Human Human +DTXSID6045375 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045375 Fup 0.0961 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045375 Vd NA 1.821 L/kg 1compartment NA NA Rat Human DTXSID6045375 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045375 TK.Half.Life NA 2.372 hours 1compartment NA NA Rat Human -DTXSID6045375 Css NA 0.2443 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045375 Css NA 1.455 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045375 Css NA 0.1514 mg/L PBTK NA 50% Rat Human -DTXSID6045375 Css NA 0.8744 mg/L PBTK NA 95% Rat Human -DTXSID6045377 Clint NA 71.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045377 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045377 Vd NA 3.073 L/kg 1compartment NA NA Human Human -DTXSID6045377 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6045377 TK.Half.Life NA 27.53 hours 1compartment NA NA Human Human -DTXSID6045377 Css NA 1.048 mg/L 3compartmentss NA 50% Human Human -DTXSID6045377 Css NA 6.561 mg/L 3compartmentss NA 95% Human Human -DTXSID6045377 Css NA 0.7223 mg/L PBTK NA 50% Human Human -DTXSID6045377 Css NA 4.453 mg/L PBTK NA 95% Human Human -DTXSID6045377 Clint NA 71.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045377 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045377 Vd NA 2.3 L/kg 1compartment NA NA Rat Human -DTXSID6045377 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6045377 TK.Half.Life NA 4.279 hours 1compartment NA NA Rat Human -DTXSID6045377 Css NA 0.5883 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045377 Css NA 2.973 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045377 Css NA 0.3861 mg/L PBTK NA 50% Rat Human -DTXSID6045377 Css NA 1.914 mg/L PBTK NA 95% Rat Human -DTXSID6045400 Clint NA 1.354 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045400 Fup NA 0.9122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045400 Vd NA 0.7881 L/kg 1compartment NA NA Human Human +DTXSID6045375 TK.Half.Life NA 2.822 hours 1compartment NA NA Rat Human +DTXSID6045375 Css NA 0.06088 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045375 Css NA 0.331 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045375 Css NA 0.04116 mg/L PBTK NA 50% Rat Human +DTXSID6045375 Css NA 0.2148 mg/L PBTK NA 95% Rat Human +DTXSID6045377 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045377 Fup 0.0538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045377 Vd NA 3.128 L/kg 1compartment NA NA Human Human +DTXSID6045377 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID6045377 TK.Half.Life NA 84.07 hours 1compartment NA NA Human Human +DTXSID6045377 Css NA 3.155 mg/L 3compartmentss NA 50% Human Human +DTXSID6045377 Css NA 19.25 mg/L 3compartmentss NA 95% Human Human +DTXSID6045377 Css NA 2.184 mg/L PBTK NA 50% Human Human +DTXSID6045377 Css NA 13 mg/L PBTK NA 95% Human Human +DTXSID6045377 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045377 Fup 0.0538 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045377 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID6045377 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID6045377 TK.Half.Life NA 11.25 hours 1compartment NA NA Rat Human +DTXSID6045377 Css NA 0.4064 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045377 Css NA 2.233 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045377 Css NA 0.2798 mg/L PBTK NA 50% Rat Human +DTXSID6045377 Css NA 1.538 mg/L PBTK NA 95% Rat Human +DTXSID6045400 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045400 Fup 0.59 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045400 Vd NA 0.6089 L/kg 1compartment NA NA Human Human DTXSID6045400 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045400 TK.Half.Life NA 1.95 hours 1compartment NA NA Human Human -DTXSID6045400 Css NA 0.275 mg/L 3compartmentss NA 50% Human Human -DTXSID6045400 Css NA 1.21 mg/L 3compartmentss NA 95% Human Human -DTXSID6045400 Css NA 0.2268 mg/L PBTK NA 50% Human Human -DTXSID6045400 Css NA 0.854 mg/L PBTK NA 95% Human Human -DTXSID6045400 Clint NA 1.354 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045400 Fup NA 0.9122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045400 Vd NA 0.8108 L/kg 1compartment NA NA Rat Human +DTXSID6045400 TK.Half.Life NA 6.684 hours 1compartment NA NA Human Human +DTXSID6045400 Css NA 1.239 mg/L 3compartmentss NA 50% Human Human +DTXSID6045400 Css NA 8.286 mg/L 3compartmentss NA 95% Human Human +DTXSID6045400 Css NA 0.9642 mg/L PBTK NA 50% Human Human +DTXSID6045400 Css NA 5.123 mg/L PBTK NA 95% Human Human +DTXSID6045400 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045400 Fup 0.59 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045400 Vd NA 0.625 L/kg 1compartment NA NA Rat Human DTXSID6045400 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045400 TK.Half.Life NA 0.996 hours 1compartment NA NA Rat Human -DTXSID6045400 Css NA 0.1089 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045400 Css NA 0.4037 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045400 Css NA 0.08931 mg/L PBTK NA 50% Rat Human -DTXSID6045400 Css NA 0.2627 mg/L PBTK NA 95% Rat Human -DTXSID6045402 Clint NA 332.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6045400 TK.Half.Life NA 2.337 hours 1compartment NA NA Rat Human +DTXSID6045400 Css NA 0.07647 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045400 Css NA 0.468 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045400 Css NA 0.05872 mg/L PBTK NA 50% Rat Human +DTXSID6045400 Css NA 0.2824 mg/L PBTK NA 95% Rat Human +DTXSID6045402 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6045402 Fup 0.26 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6045402 Vd NA 5.535 L/kg 1compartment NA NA Human Human +DTXSID6045402 Vd NA 2.808 L/kg 1compartment NA NA Human Human DTXSID6045402 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045402 TK.Half.Life NA 2.142 hours 1compartment NA NA Human Human -DTXSID6045402 Css NA 0.001964 mg/L 3compartmentss NA 50% Human Human -DTXSID6045402 Css NA 0.02008 mg/L 3compartmentss NA 95% Human Human -DTXSID6045402 Css NA 0.002942 mg/L PBTK NA 50% Human Human -DTXSID6045402 Css NA 0.02207 mg/L PBTK NA 95% Human Human -DTXSID6045402 Clint NA 332.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6045402 TK.Half.Life NA 8.827 hours 1compartment NA NA Human Human +DTXSID6045402 Css NA 0.2434 mg/L 3compartmentss NA 50% Human Human +DTXSID6045402 Css NA 1.507 mg/L 3compartmentss NA 95% Human Human +DTXSID6045402 Css NA 0.177 mg/L PBTK NA 50% Human Human +DTXSID6045402 Css NA 1.053 mg/L PBTK NA 95% Human Human +DTXSID6045402 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6045402 Fup 0.26 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6045402 Vd NA 5.716 L/kg 1compartment NA NA Rat Human +DTXSID6045402 Vd NA 2.133 L/kg 1compartment NA NA Rat Human DTXSID6045402 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045402 TK.Half.Life NA 1.01 hours 1compartment NA NA Rat Human -DTXSID6045402 Css NA 0.001052 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045402 Css NA 0.008357 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045402 Css NA 0.00158 mg/L PBTK NA 50% Rat Human -DTXSID6045402 Css NA 0.009315 mg/L PBTK NA 95% Rat Human -DTXSID6045452 Clint NA 14.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045452 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045452 Vd NA 2.775 L/kg 1compartment NA NA Human Human -DTXSID6045452 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID6045452 TK.Half.Life NA 67.96 hours 1compartment NA NA Human Human -DTXSID6045452 Css NA 3.431 mg/L 3compartmentss NA 50% Human Human -DTXSID6045452 Css NA 22.29 mg/L 3compartmentss NA 95% Human Human -DTXSID6045452 Css NA 2.31 mg/L PBTK NA 50% Human Human -DTXSID6045452 Css NA 14.6 mg/L PBTK NA 95% Human Human -DTXSID6045452 Clint NA 14.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045452 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045452 Vd NA 2.079 L/kg 1compartment NA NA Rat Human -DTXSID6045452 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID6045452 TK.Half.Life NA 13.63 hours 1compartment NA NA Rat Human -DTXSID6045452 Css NA 1.91 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045452 Css NA 10.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045452 Css NA 1.226 mg/L PBTK NA 50% Rat Human -DTXSID6045452 Css NA 6.433 mg/L PBTK NA 95% Rat Human -DTXSID6045531 Clint NA 17.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045531 Fup NA 0.4616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045531 Vd NA 1.547 L/kg 1compartment NA NA Human Human +DTXSID6045402 TK.Half.Life NA 2.031 hours 1compartment NA NA Rat Human +DTXSID6045402 Css NA 0.01195 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045402 Css NA 0.07746 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045402 Css NA 0.008586 mg/L PBTK NA 50% Rat Human +DTXSID6045402 Css NA 0.05268 mg/L PBTK NA 95% Rat Human +DTXSID6045408 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045408 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6045408 Vd NA 0.1665 L/kg 1compartment NA NA Human Human +DTXSID6045408 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6045408 TK.Half.Life NA 23.55 hours 1compartment NA NA Human Human +DTXSID6045408 Css NA 26.26 mg/L 3compartmentss NA 50% Human Human +DTXSID6045408 Css NA 157 mg/L 3compartmentss NA 95% Human Human +DTXSID6045408 Css NA 15.29 mg/L PBTK NA 50% Human Human +DTXSID6045408 Css NA 90.74 mg/L PBTK NA 95% Human Human +DTXSID6045408 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045408 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6045408 Vd NA 0.1647 L/kg 1compartment NA NA Rat Human +DTXSID6045408 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6045408 TK.Half.Life NA 14.94 hours 1compartment NA NA Rat Human +DTXSID6045408 Css NA 3.214 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045408 Css NA 13.96 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045408 Css NA 1.801 mg/L PBTK NA 50% Rat Human +DTXSID6045408 Css NA 7.824 mg/L PBTK NA 95% Rat Human +DTXSID6045452 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045452 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045452 Vd NA 0.533 L/kg 1compartment NA NA Human Human +DTXSID6045452 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045452 TK.Half.Life NA 0.9591 hours 1compartment NA NA Human Human +DTXSID6045452 Css NA 0.1263 mg/L 3compartmentss NA 50% Human Human +DTXSID6045452 Css NA 0.9013 mg/L 3compartmentss NA 95% Human Human +DTXSID6045452 Css NA 0.0842 mg/L PBTK NA 50% Human Human +DTXSID6045452 Css NA 0.5713 mg/L PBTK NA 95% Human Human +DTXSID6045452 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045452 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045452 Vd NA 0.5212 L/kg 1compartment NA NA Rat Human +DTXSID6045452 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6045452 TK.Half.Life NA 0.5275 hours 1compartment NA NA Rat Human +DTXSID6045452 Css NA 0.01593 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045452 Css NA 0.08495 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045452 Css NA 0.01043 mg/L PBTK NA 50% Rat Human +DTXSID6045452 Css NA 0.05243 mg/L PBTK NA 95% Rat Human +DTXSID6045531 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045531 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045531 Vd NA 0.5158 L/kg 1compartment NA NA Human Human DTXSID6045531 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045531 TK.Half.Life NA 1.585 hours 1compartment NA NA Human Human -DTXSID6045531 Css NA 0.04822 mg/L 3compartmentss NA 50% Human Human -DTXSID6045531 Css NA 0.4091 mg/L 3compartmentss NA 95% Human Human -DTXSID6045531 Css NA 0.04246 mg/L PBTK NA 50% Human Human -DTXSID6045531 Css NA 0.3041 mg/L PBTK NA 95% Human Human -DTXSID6045531 Clint NA 17.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045531 Fup NA 0.4616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045531 Vd NA 1.559 L/kg 1compartment NA NA Rat Human +DTXSID6045531 TK.Half.Life NA 6.07 hours 1compartment NA NA Human Human +DTXSID6045531 Css NA 1.2 mg/L 3compartmentss NA 50% Human Human +DTXSID6045531 Css NA 7.442 mg/L 3compartmentss NA 95% Human Human +DTXSID6045531 Css NA 0.9066 mg/L PBTK NA 50% Human Human +DTXSID6045531 Css NA 4.639 mg/L PBTK NA 95% Human Human +DTXSID6045531 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045531 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045531 Vd NA 0.546 L/kg 1compartment NA NA Rat Human DTXSID6045531 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045531 TK.Half.Life NA 0.8455 hours 1compartment NA NA Rat Human -DTXSID6045531 Css NA 0.0248 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045531 Css NA 0.1687 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045531 Css NA 0.02146 mg/L PBTK NA 50% Rat Human -DTXSID6045531 Css NA 0.119 mg/L PBTK NA 95% Rat Human -DTXSID6045533 Clint NA 39.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045533 Fup NA 0.0437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045533 Vd NA 2.497 L/kg 1compartment NA NA Human Human +DTXSID6045531 TK.Half.Life NA 2.189 hours 1compartment NA NA Rat Human +DTXSID6045531 Css NA 0.02994 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045531 Css NA 0.2331 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045531 Css NA 0.0221 mg/L PBTK NA 50% Rat Human +DTXSID6045531 Css NA 0.1436 mg/L PBTK NA 95% Rat Human +DTXSID6045533 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045533 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045533 Vd NA 0.3198 L/kg 1compartment NA NA Human Human DTXSID6045533 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045533 TK.Half.Life NA 11.53 hours 1compartment NA NA Human Human -DTXSID6045533 Css NA 0.5565 mg/L 3compartmentss NA 50% Human Human -DTXSID6045533 Css NA 3.811 mg/L 3compartmentss NA 95% Human Human -DTXSID6045533 Css NA 0.3752 mg/L PBTK NA 50% Human Human -DTXSID6045533 Css NA 2.447 mg/L PBTK NA 95% Human Human -DTXSID6045533 Clint NA 39.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045533 Fup NA 0.0437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045533 Vd NA 1.872 L/kg 1compartment NA NA Rat Human +DTXSID6045533 TK.Half.Life NA 0.6704 hours 1compartment NA NA Human Human +DTXSID6045533 Css NA 0.1948 mg/L 3compartmentss NA 50% Human Human +DTXSID6045533 Css NA 1.638 mg/L 3compartmentss NA 95% Human Human +DTXSID6045533 Css NA 0.1213 mg/L PBTK NA 50% Human Human +DTXSID6045533 Css NA 0.9886 mg/L PBTK NA 95% Human Human +DTXSID6045533 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045533 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045533 Vd NA 0.3235 L/kg 1compartment NA NA Rat Human DTXSID6045533 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045533 TK.Half.Life NA 3.022 hours 1compartment NA NA Rat Human -DTXSID6045533 Css NA 0.3144 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045533 Css NA 1.822 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045533 Css NA 0.2012 mg/L PBTK NA 50% Rat Human -DTXSID6045533 Css NA 1.124 mg/L PBTK NA 95% Rat Human -DTXSID6045535 Clint NA 4.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045535 Fup NA 0.061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045535 Vd NA 2.626 L/kg 1compartment NA NA Human Human -DTXSID6045535 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID6045535 TK.Half.Life NA 73.87 hours 1compartment NA NA Human Human -DTXSID6045535 Css NA 3.837 mg/L 3compartmentss NA 50% Human Human -DTXSID6045535 Css NA 21.06 mg/L 3compartmentss NA 95% Human Human -DTXSID6045535 Css NA 2.614 mg/L PBTK NA 50% Human Human -DTXSID6045535 Css NA 13.78 mg/L PBTK NA 95% Human Human -DTXSID6045535 Clint NA 4.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045535 Fup NA 0.061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045535 Vd NA 1.974 L/kg 1compartment NA NA Rat Human -DTXSID6045535 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID6045535 TK.Half.Life NA 16 hours 1compartment NA NA Rat Human -DTXSID6045535 Css NA 2.042 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045535 Css NA 7.935 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045535 Css NA 1.321 mg/L PBTK NA 50% Rat Human -DTXSID6045535 Css NA 4.899 mg/L PBTK NA 95% Rat Human -DTXSID6045537 Clint NA 32.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6045533 TK.Half.Life NA 0.389 hours 1compartment NA NA Rat Human +DTXSID6045533 Css NA 0.02499 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045533 Css NA 0.1522 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045533 Css NA 0.01525 mg/L PBTK NA 50% Rat Human +DTXSID6045533 Css NA 0.09003 mg/L PBTK NA 95% Rat Human +DTXSID6045535 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045535 Fup 0.0735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045535 Vd NA 1.261 L/kg 1compartment NA NA Human Human +DTXSID6045535 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045535 TK.Half.Life NA 4.25 hours 1compartment NA NA Human Human +DTXSID6045535 Css NA 0.3979 mg/L 3compartmentss NA 50% Human Human +DTXSID6045535 Css NA 3.163 mg/L 3compartmentss NA 95% Human Human +DTXSID6045535 Css NA 0.2572 mg/L PBTK NA 50% Human Human +DTXSID6045535 Css NA 1.945 mg/L PBTK NA 95% Human Human +DTXSID6045535 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045535 Fup 0.0735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045535 Vd NA 0.9714 L/kg 1compartment NA NA Rat Human +DTXSID6045535 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6045535 TK.Half.Life NA 1.77 hours 1compartment NA NA Rat Human +DTXSID6045535 Css NA 0.05238 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045535 Css NA 0.3177 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045535 Css NA 0.03294 mg/L PBTK NA 50% Rat Human +DTXSID6045535 Css NA 0.191 mg/L PBTK NA 95% Rat Human +DTXSID6045537 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6045537 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6045537 Vd NA 1.406 L/kg 1compartment NA NA Human Human -DTXSID6045537 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045537 TK.Half.Life NA 1.678 hours 1compartment NA NA Human Human -DTXSID6045537 Css NA 0.0574 mg/L 3compartmentss NA 50% Human Human -DTXSID6045537 Css NA 0.4334 mg/L 3compartmentss NA 95% Human Human -DTXSID6045537 Css NA 0.04462 mg/L PBTK NA 50% Human Human -DTXSID6045537 Css NA 0.3019 mg/L PBTK NA 95% Human Human -DTXSID6045537 Clint NA 32.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6045537 Vd NA 1.349 L/kg 1compartment NA NA Human Human +DTXSID6045537 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID6045537 TK.Half.Life NA 44.23 hours 1compartment NA NA Human Human +DTXSID6045537 Css NA 3.513 mg/L 3compartmentss NA 50% Human Human +DTXSID6045537 Css NA 12.73 mg/L 3compartmentss NA 95% Human Human +DTXSID6045537 Css NA 2.59 mg/L PBTK NA 50% Human Human +DTXSID6045537 Css NA 8.271 mg/L PBTK NA 95% Human Human +DTXSID6045537 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6045537 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6045537 Vd NA 1.308 L/kg 1compartment NA NA Rat Human -DTXSID6045537 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045537 TK.Half.Life NA 0.8116 hours 1compartment NA NA Rat Human -DTXSID6045537 Css NA 0.03156 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045537 Css NA 0.1811 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045537 Css NA 0.02379 mg/L PBTK NA 50% Rat Human -DTXSID6045537 Css NA 0.1223 mg/L PBTK NA 95% Rat Human -DTXSID6045539 Clint NA 6.752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045539 Fup NA 0.2583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045539 Vd NA 1.994 L/kg 1compartment NA NA Human Human +DTXSID6045537 Vd NA 1.1 L/kg 1compartment NA NA Rat Human +DTXSID6045537 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6045537 TK.Half.Life NA 10.63 hours 1compartment NA NA Rat Human +DTXSID6045537 Css NA 0.225 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045537 Css NA 0.7042 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045537 Css NA 0.164 mg/L PBTK NA 50% Rat Human +DTXSID6045537 Css NA 0.4389 mg/L PBTK NA 95% Rat Human +DTXSID6045539 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045539 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045539 Vd NA 1.082 L/kg 1compartment NA NA Human Human DTXSID6045539 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045539 TK.Half.Life NA 6.424 hours 1compartment NA NA Human Human -DTXSID6045539 Css NA 0.294 mg/L 3compartmentss NA 50% Human Human -DTXSID6045539 Css NA 1.73 mg/L 3compartmentss NA 95% Human Human -DTXSID6045539 Css NA 0.231 mg/L PBTK NA 50% Human Human -DTXSID6045539 Css NA 1.239 mg/L PBTK NA 95% Human Human -DTXSID6045539 Clint NA 6.752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045539 Fup NA 0.2583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045539 Vd NA 1.673 L/kg 1compartment NA NA Rat Human +DTXSID6045539 TK.Half.Life NA 1.3 hours 1compartment NA NA Human Human +DTXSID6045539 Css NA 0.05747 mg/L 3compartmentss NA 50% Human Human +DTXSID6045539 Css NA 0.4381 mg/L 3compartmentss NA 95% Human Human +DTXSID6045539 Css NA 0.04378 mg/L PBTK NA 50% Human Human +DTXSID6045539 Css NA 0.3066 mg/L PBTK NA 95% Human Human +DTXSID6045539 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045539 Fup 0.351 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045539 Vd NA 0.9321 L/kg 1compartment NA NA Rat Human DTXSID6045539 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045539 TK.Half.Life NA 2.598 hours 1compartment NA NA Rat Human -DTXSID6045539 Css NA 0.1496 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045539 Css NA 0.6573 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045539 Css NA 0.1139 mg/L PBTK NA 50% Rat Human -DTXSID6045539 Css NA 0.445 mg/L PBTK NA 95% Rat Human -DTXSID6045581 Clint NA 1.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045581 Fup NA 0.2174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045581 Vd NA 0.3818 L/kg 1compartment NA NA Human Human +DTXSID6045539 TK.Half.Life NA 0.57 hours 1compartment NA NA Rat Human +DTXSID6045539 Css NA 0.007076 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045539 Css NA 0.04328 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045539 Css NA 0.005419 mg/L PBTK NA 50% Rat Human +DTXSID6045539 Css NA 0.02968 mg/L PBTK NA 95% Rat Human +DTXSID6045581 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045581 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045581 Vd NA 0.4908 L/kg 1compartment NA NA Human Human DTXSID6045581 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045581 TK.Half.Life NA 3.403 hours 1compartment NA NA Human Human -DTXSID6045581 Css NA 1.057 mg/L 3compartmentss NA 50% Human Human -DTXSID6045581 Css NA 4.76 mg/L 3compartmentss NA 95% Human Human -DTXSID6045581 Css NA 0.7102 mg/L PBTK NA 50% Human Human -DTXSID6045581 Css NA 2.967 mg/L PBTK NA 95% Human Human -DTXSID6045581 Clint NA 1.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045581 Fup NA 0.2174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045581 Vd NA 0.3841 L/kg 1compartment NA NA Rat Human +DTXSID6045581 TK.Half.Life NA 1.054 hours 1compartment NA NA Human Human +DTXSID6045581 Css NA 0.08896 mg/L 3compartmentss NA 50% Human Human +DTXSID6045581 Css NA 0.6705 mg/L 3compartmentss NA 95% Human Human +DTXSID6045581 Css NA 0.06493 mg/L PBTK NA 50% Human Human +DTXSID6045581 Css NA 0.4446 mg/L PBTK NA 95% Human Human +DTXSID6045581 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045581 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045581 Vd NA 0.4968 L/kg 1compartment NA NA Rat Human DTXSID6045581 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045581 TK.Half.Life NA 1.8 hours 1compartment NA NA Rat Human -DTXSID6045581 Css NA 0.463 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045581 Css NA 1.632 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045581 Css NA 0.294 mg/L PBTK NA 50% Rat Human -DTXSID6045581 Css NA 0.9412 mg/L PBTK NA 95% Rat Human -DTXSID6045583 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045583 Fup NA 0.0713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045583 Vd NA 0.8262 L/kg 1compartment NA NA Human Human -DTXSID6045583 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID6045583 TK.Half.Life NA 82.85 hours 1compartment NA NA Human Human -DTXSID6045583 Css NA 14.83 mg/L 3compartmentss NA 50% Human Human -DTXSID6045583 Css NA 55.57 mg/L 3compartmentss NA 95% Human Human -DTXSID6045583 Css NA 9.406 mg/L PBTK NA 50% Human Human -DTXSID6045583 Css NA 33.57 mg/L PBTK NA 95% Human Human -DTXSID6045583 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045583 Fup NA 0.0713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045583 Vd NA 0.6436 L/kg 1compartment NA NA Rat Human -DTXSID6045583 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6045583 TK.Half.Life NA 20.4 hours 1compartment NA NA Rat Human -DTXSID6045583 Css NA 4.144 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045583 Css NA 13.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045583 Css NA 2.468 mg/L PBTK NA 50% Rat Human -DTXSID6045583 Css NA 7.429 mg/L PBTK NA 95% Rat Human -DTXSID6045585 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045585 Fup NA 0.399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045585 Vd NA 0.4197 L/kg 1compartment NA NA Human Human +DTXSID6045581 TK.Half.Life NA 0.5996 hours 1compartment NA NA Rat Human +DTXSID6045581 Css NA 0.0008336 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045581 Css NA 0.005259 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045581 Css NA 0.0005845 mg/L PBTK NA 50% Rat Human +DTXSID6045581 Css NA 0.003319 mg/L PBTK NA 95% Rat Human +DTXSID6045583 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045583 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045583 Vd NA 0.621 L/kg 1compartment NA NA Human Human +DTXSID6045583 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6045583 TK.Half.Life NA 10.78 hours 1compartment NA NA Human Human +DTXSID6045583 Css NA 1.862 mg/L 3compartmentss NA 50% Human Human +DTXSID6045583 Css NA 7.927 mg/L 3compartmentss NA 95% Human Human +DTXSID6045583 Css NA 1.382 mg/L PBTK NA 50% Human Human +DTXSID6045583 Css NA 5.065 mg/L PBTK NA 95% Human Human +DTXSID6045583 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045583 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045583 Vd NA 0.6054 L/kg 1compartment NA NA Rat Human +DTXSID6045583 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6045583 TK.Half.Life NA 3.556 hours 1compartment NA NA Rat Human +DTXSID6045583 Css NA 0.1208 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045583 Css NA 0.4384 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045583 Css NA 0.08813 mg/L PBTK NA 50% Rat Human +DTXSID6045583 Css NA 0.2697 mg/L PBTK NA 95% Rat Human +DTXSID6045585 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045585 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045585 Vd NA 0.2685 L/kg 1compartment NA NA Human Human DTXSID6045585 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045585 TK.Half.Life NA 6.802 hours 1compartment NA NA Human Human -DTXSID6045585 Css NA 1.901 mg/L 3compartmentss NA 50% Human Human -DTXSID6045585 Css NA 8.116 mg/L 3compartmentss NA 95% Human Human -DTXSID6045585 Css NA 1.352 mg/L PBTK NA 50% Human Human -DTXSID6045585 Css NA 5.083 mg/L PBTK NA 95% Human Human -DTXSID6045585 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045585 Fup NA 0.399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045585 Vd NA 0.4374 L/kg 1compartment NA NA Rat Human +DTXSID6045585 TK.Half.Life NA 1.093 hours 1compartment NA NA Human Human +DTXSID6045585 Css NA 0.2682 mg/L 3compartmentss NA 50% Human Human +DTXSID6045585 Css NA 2.101 mg/L 3compartmentss NA 95% Human Human +DTXSID6045585 Css NA 0.1669 mg/L PBTK NA 50% Human Human +DTXSID6045585 Css NA 1.262 mg/L PBTK NA 95% Human Human +DTXSID6045585 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045585 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045585 Vd NA 0.2762 L/kg 1compartment NA NA Rat Human DTXSID6045585 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045585 TK.Half.Life NA 2.418 hours 1compartment NA NA Rat Human -DTXSID6045585 Css NA 0.5193 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045585 Css NA 1.877 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045585 Css NA 0.3503 mg/L PBTK NA 50% Rat Human -DTXSID6045585 Css NA 1.094 mg/L PBTK NA 95% Rat Human -DTXSID6045614 Clint NA 42.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6045585 TK.Half.Life NA 0.6736 hours 1compartment NA NA Rat Human +DTXSID6045585 Css NA 0.002763 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045585 Css NA 0.01848 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045585 Css NA 0.00162 mg/L PBTK NA 50% Rat Human +DTXSID6045585 Css NA 0.01039 mg/L PBTK NA 95% Rat Human +DTXSID6045587 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045587 Fup 0.00725 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045587 Vd NA 0.2022 L/kg 1compartment NA NA Human Human +DTXSID6045587 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045587 TK.Half.Life NA 4.972 hours 1compartment NA NA Human Human +DTXSID6045587 Css NA 4.455 mg/L 3compartmentss NA 50% Human Human +DTXSID6045587 Css NA 44.83 mg/L 3compartmentss NA 95% Human Human +DTXSID6045587 Css NA 2.606 mg/L PBTK NA 50% Human Human +DTXSID6045587 Css NA 26.18 mg/L PBTK NA 95% Human Human +DTXSID6045587 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045587 Fup 0.00725 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045587 Vd NA 0.193 L/kg 1compartment NA NA Rat Human +DTXSID6045587 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6045587 TK.Half.Life NA 3.194 hours 1compartment NA NA Rat Human +DTXSID6045587 Css NA 0.5908 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045587 Css NA 4.64 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045587 Css NA 0.3352 mg/L PBTK NA 50% Rat Human +DTXSID6045587 Css NA 2.617 mg/L PBTK NA 95% Rat Human +DTXSID6045614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6045614 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6045614 Vd NA 1.484 L/kg 1compartment NA NA Human Human +DTXSID6045614 Vd NA 1.609 L/kg 1compartment NA NA Human Human DTXSID6045614 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045614 TK.Half.Life NA 3.421 hours 1compartment NA NA Human Human -DTXSID6045614 Css NA 0.2386 mg/L 3compartmentss NA 50% Human Human -DTXSID6045614 Css NA 1.774 mg/L 3compartmentss NA 95% Human Human -DTXSID6045614 Css NA 0.1543 mg/L PBTK NA 50% Human Human -DTXSID6045614 Css NA 1.085 mg/L PBTK NA 95% Human Human -DTXSID6045614 Clint NA 42.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6045614 TK.Half.Life NA 6.043 hours 1compartment NA NA Human Human +DTXSID6045614 Css NA 0.3885 mg/L 3compartmentss NA 50% Human Human +DTXSID6045614 Css NA 3.026 mg/L 3compartmentss NA 95% Human Human +DTXSID6045614 Css NA 0.2558 mg/L PBTK NA 50% Human Human +DTXSID6045614 Css NA 1.889 mg/L PBTK NA 95% Human Human +DTXSID6045614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6045614 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6045614 Vd NA 1.128 L/kg 1compartment NA NA Rat Human +DTXSID6045614 Vd NA 1.219 L/kg 1compartment NA NA Rat Human DTXSID6045614 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045614 TK.Half.Life NA 1.309 hours 1compartment NA NA Rat Human -DTXSID6045614 Css NA 0.1335 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045614 Css NA 0.7846 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045614 Css NA 0.08178 mg/L PBTK NA 50% Rat Human -DTXSID6045614 Css NA 0.4626 mg/L PBTK NA 95% Rat Human -DTXSID6045616 Clint NA 97.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045616 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045616 Vd NA 3.059 L/kg 1compartment NA NA Human Human -DTXSID6045616 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045616 TK.Half.Life NA 9.353 hours 1compartment NA NA Human Human -DTXSID6045616 Css NA 0.2906 mg/L 3compartmentss NA 50% Human Human -DTXSID6045616 Css NA 1.927 mg/L 3compartmentss NA 95% Human Human -DTXSID6045616 Css NA 0.2018 mg/L PBTK NA 50% Human Human -DTXSID6045616 Css NA 1.281 mg/L PBTK NA 95% Human Human -DTXSID6045616 Clint NA 97.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045616 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045616 Vd NA 2.303 L/kg 1compartment NA NA Rat Human -DTXSID6045616 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045616 TK.Half.Life NA 1.842 hours 1compartment NA NA Rat Human -DTXSID6045616 Css NA 0.1638 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045616 Css NA 0.8859 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045616 Css NA 0.1081 mg/L PBTK NA 50% Rat Human -DTXSID6045616 Css NA 0.5634 mg/L PBTK NA 95% Rat Human -DTXSID6045618 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045618 Fup NA 0.7571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045618 Vd NA 1.881 L/kg 1compartment NA NA Human Human +DTXSID6045614 TK.Half.Life NA 2.276 hours 1compartment NA NA Rat Human +DTXSID6045614 Css NA 0.01952 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045614 Css NA 0.1538 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045614 Css NA 0.01233 mg/L PBTK NA 50% Rat Human +DTXSID6045614 Css NA 0.09405 mg/L PBTK NA 95% Rat Human +DTXSID6045616 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045616 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045616 Vd NA 3.094 L/kg 1compartment NA NA Human Human +DTXSID6045616 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6045616 TK.Half.Life NA 33.13 hours 1compartment NA NA Human Human +DTXSID6045616 Css NA 1.242 mg/L 3compartmentss NA 50% Human Human +DTXSID6045616 Css NA 8.294 mg/L 3compartmentss NA 95% Human Human +DTXSID6045616 Css NA 0.859 mg/L PBTK NA 50% Human Human +DTXSID6045616 Css NA 5.525 mg/L PBTK NA 95% Human Human +DTXSID6045616 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045616 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045616 Vd NA 2.331 L/kg 1compartment NA NA Rat Human +DTXSID6045616 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6045616 TK.Half.Life NA 5.169 hours 1compartment NA NA Rat Human +DTXSID6045616 Css NA 0.1599 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045616 Css NA 0.9359 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045616 Css NA 0.1097 mg/L PBTK NA 50% Rat Human +DTXSID6045616 Css NA 0.6156 mg/L PBTK NA 95% Rat Human +DTXSID6045618 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045618 Fup 0.827 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045618 Vd NA 1.929 L/kg 1compartment NA NA Human Human DTXSID6045618 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6045618 TK.Half.Life NA 16.07 hours 1compartment NA NA Human Human -DTXSID6045618 Css NA 0.8372 mg/L 3compartmentss NA 50% Human Human -DTXSID6045618 Css NA 5.925 mg/L 3compartmentss NA 95% Human Human -DTXSID6045618 Css NA 0.838 mg/L PBTK NA 50% Human Human -DTXSID6045618 Css NA 4.073 mg/L PBTK NA 95% Human Human -DTXSID6045618 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045618 Fup NA 0.7571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045618 Vd NA 1.91 L/kg 1compartment NA NA Rat Human +DTXSID6045618 TK.Half.Life NA 15.09 hours 1compartment NA NA Human Human +DTXSID6045618 Css NA 0.4328 mg/L 3compartmentss NA 50% Human Human +DTXSID6045618 Css NA 3.032 mg/L 3compartmentss NA 95% Human Human +DTXSID6045618 Css NA 0.4408 mg/L PBTK NA 50% Human Human +DTXSID6045618 Css NA 2.13 mg/L PBTK NA 95% Human Human +DTXSID6045618 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045618 Fup 0.827 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045618 Vd NA 1.962 L/kg 1compartment NA NA Rat Human DTXSID6045618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045618 TK.Half.Life NA 5.563 hours 1compartment NA NA Rat Human -DTXSID6045618 Css NA 0.2124 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045618 Css NA 1.511 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045618 Css NA 0.2094 mg/L PBTK NA 50% Rat Human -DTXSID6045618 Css NA 0.9625 mg/L PBTK NA 95% Rat Human -DTXSID6045660 Clint NA 6.917 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045660 Fup NA 0.2556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045660 Vd NA 3.655 L/kg 1compartment NA NA Human Human +DTXSID6045618 TK.Half.Life NA 5.231 hours 1compartment NA NA Rat Human +DTXSID6045618 Css NA 0.002192 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045618 Css NA 0.01656 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045618 Css NA 0.002187 mg/L PBTK NA 50% Rat Human +DTXSID6045618 Css NA 0.01132 mg/L PBTK NA 95% Rat Human +DTXSID6045660 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045660 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045660 Vd NA 1.061 L/kg 1compartment NA NA Human Human DTXSID6045660 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045660 TK.Half.Life NA 11.91 hours 1compartment NA NA Human Human -DTXSID6045660 Css NA 0.248 mg/L 3compartmentss NA 50% Human Human -DTXSID6045660 Css NA 1.557 mg/L 3compartmentss NA 95% Human Human -DTXSID6045660 Css NA 0.245 mg/L PBTK NA 50% Human Human -DTXSID6045660 Css NA 1.355 mg/L PBTK NA 95% Human Human -DTXSID6045660 Clint NA 6.917 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045660 Fup NA 0.2556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045660 Vd NA 3.319 L/kg 1compartment NA NA Rat Human +DTXSID6045660 TK.Half.Life NA 1.102 hours 1compartment NA NA Human Human +DTXSID6045660 Css NA 0.04239 mg/L 3compartmentss NA 50% Human Human +DTXSID6045660 Css NA 0.3637 mg/L 3compartmentss NA 95% Human Human +DTXSID6045660 Css NA 0.03418 mg/L PBTK NA 50% Human Human +DTXSID6045660 Css NA 0.2608 mg/L PBTK NA 95% Human Human +DTXSID6045660 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045660 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045660 Vd NA 1.077 L/kg 1compartment NA NA Rat Human DTXSID6045660 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045660 TK.Half.Life NA 4.519 hours 1compartment NA NA Rat Human -DTXSID6045660 Css NA 0.1276 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045660 Css NA 0.5887 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045660 Css NA 0.124 mg/L PBTK NA 50% Rat Human -DTXSID6045660 Css NA 0.4899 mg/L PBTK NA 95% Rat Human -DTXSID6045662 Clint NA 44.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045662 Fup NA 0.056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045662 Vd NA 2.734 L/kg 1compartment NA NA Human Human +DTXSID6045660 TK.Half.Life NA 0.5796 hours 1compartment NA NA Rat Human +DTXSID6045660 Css NA 0.005218 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045660 Css NA 0.03608 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045660 Css NA 0.004252 mg/L PBTK NA 50% Rat Human +DTXSID6045660 Css NA 0.02452 mg/L PBTK NA 95% Rat Human +DTXSID6045662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045662 Fup 0.035 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045662 Vd NA 2.648 L/kg 1compartment NA NA Human Human DTXSID6045662 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045662 TK.Half.Life NA 5.514 hours 1compartment NA NA Human Human -DTXSID6045662 Css NA 0.1773 mg/L 3compartmentss NA 50% Human Human -DTXSID6045662 Css NA 1.367 mg/L 3compartmentss NA 95% Human Human -DTXSID6045662 Css NA 0.1316 mg/L PBTK NA 50% Human Human -DTXSID6045662 Css NA 0.95 mg/L PBTK NA 95% Human Human -DTXSID6045662 Clint NA 44.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045662 Fup NA 0.056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045662 Vd NA 2.279 L/kg 1compartment NA NA Rat Human +DTXSID6045662 TK.Half.Life NA 11.18 hours 1compartment NA NA Human Human +DTXSID6045662 Css NA 0.4938 mg/L 3compartmentss NA 50% Human Human +DTXSID6045662 Css NA 3.57 mg/L 3compartmentss NA 95% Human Human +DTXSID6045662 Css NA 0.3484 mg/L PBTK NA 50% Human Human +DTXSID6045662 Css NA 2.409 mg/L PBTK NA 95% Human Human +DTXSID6045662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045662 Fup 0.035 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045662 Vd NA 2.138 L/kg 1compartment NA NA Rat Human DTXSID6045662 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045662 TK.Half.Life NA 1.977 hours 1compartment NA NA Rat Human -DTXSID6045662 Css NA 0.0994 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045662 Css NA 0.6091 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045662 Css NA 0.07048 mg/L PBTK NA 50% Rat Human -DTXSID6045662 Css NA 0.4088 mg/L PBTK NA 95% Rat Human -DTXSID6045666 Clint NA 35.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045666 Fup NA 0.3734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045666 Vd NA 1.059 L/kg 1compartment NA NA Human Human +DTXSID6045662 TK.Half.Life NA 3.648 hours 1compartment NA NA Rat Human +DTXSID6045662 Css NA 0.06325 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045662 Css NA 0.3837 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045662 Css NA 0.04463 mg/L PBTK NA 50% Rat Human +DTXSID6045662 Css NA 0.2538 mg/L PBTK NA 95% Rat Human +DTXSID6045666 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045666 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045666 Vd NA 1.041 L/kg 1compartment NA NA Human Human DTXSID6045666 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045666 TK.Half.Life NA 1.041 hours 1compartment NA NA Human Human -DTXSID6045666 Css NA 0.03515 mg/L 3compartmentss NA 50% Human Human -DTXSID6045666 Css NA 0.2662 mg/L 3compartmentss NA 95% Human Human -DTXSID6045666 Css NA 0.02718 mg/L PBTK NA 50% Human Human -DTXSID6045666 Css NA 0.1857 mg/L PBTK NA 95% Human Human -DTXSID6045666 Clint NA 35.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045666 Fup NA 0.3734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045666 Vd NA 0.9276 L/kg 1compartment NA NA Rat Human +DTXSID6045666 TK.Half.Life NA 2.831 hours 1compartment NA NA Human Human +DTXSID6045666 Css NA 0.239 mg/L 3compartmentss NA 50% Human Human +DTXSID6045666 Css NA 1.473 mg/L 3compartmentss NA 95% Human Human +DTXSID6045666 Css NA 0.1762 mg/L PBTK NA 50% Human Human +DTXSID6045666 Css NA 0.9954 mg/L PBTK NA 95% Human Human +DTXSID6045666 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045666 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045666 Vd NA 0.8883 L/kg 1compartment NA NA Rat Human DTXSID6045666 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045666 TK.Half.Life NA 0.4475 hours 1compartment NA NA Rat Human -DTXSID6045666 Css NA 0.01883 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045666 Css NA 0.1206 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045666 Css NA 0.01411 mg/L PBTK NA 50% Rat Human -DTXSID6045666 Css NA 0.08176 mg/L PBTK NA 95% Rat Human -DTXSID6045668 Clint NA 6.051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6045666 TK.Half.Life NA 1.322 hours 1compartment NA NA Rat Human +DTXSID6045666 Css NA 0.02655 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045666 Css NA 0.1253 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045666 Css NA 0.01954 mg/L PBTK NA 50% Rat Human +DTXSID6045666 Css NA 0.08121 mg/L PBTK NA 95% Rat Human +DTXSID6045668 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6045668 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6045668 Vd NA 1.736 L/kg 1compartment NA NA Human Human DTXSID6045668 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045668 TK.Half.Life NA 7.082 hours 1compartment NA NA Human Human -DTXSID6045668 Css NA 0.4646 mg/L 3compartmentss NA 50% Human Human -DTXSID6045668 Css NA 3.116 mg/L 3compartmentss NA 95% Human Human -DTXSID6045668 Css NA 0.3266 mg/L PBTK NA 50% Human Human -DTXSID6045668 Css NA 2.004 mg/L PBTK NA 95% Human Human -DTXSID6045668 Clint NA 6.051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6045668 TK.Half.Life NA 6.918 hours 1compartment NA NA Human Human +DTXSID6045668 Css NA 0.4343 mg/L 3compartmentss NA 50% Human Human +DTXSID6045668 Css NA 2.683 mg/L 3compartmentss NA 95% Human Human +DTXSID6045668 Css NA 0.3034 mg/L PBTK NA 50% Human Human +DTXSID6045668 Css NA 1.877 mg/L PBTK NA 95% Human Human +DTXSID6045668 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6045668 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6045668 Vd NA 5.231 L/kg 1compartment NA NA Rat Human DTXSID6045668 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045668 TK.Half.Life NA 3.209 hours 1compartment NA NA Rat Human -DTXSID6045668 Css NA 0.05426 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045668 Css NA 0.3665 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045668 Css NA 0.03588 mg/L PBTK NA 50% Rat Human -DTXSID6045668 Css NA 0.2139 mg/L PBTK NA 95% Rat Human -DTXSID6045741 Clint NA 0.2282 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045741 Fup NA 0.0686 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045741 Vd NA 1.224 L/kg 1compartment NA NA Human Human -DTXSID6045741 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID6045741 TK.Half.Life NA 99.49 hours 1compartment NA NA Human Human -DTXSID6045741 Css NA 12.39 mg/L 3compartmentss NA 50% Human Human -DTXSID6045741 Css NA 53 mg/L 3compartmentss NA 95% Human Human -DTXSID6045741 Css NA 7.944 mg/L PBTK NA 50% Human Human -DTXSID6045741 Css NA 31.52 mg/L PBTK NA 95% Human Human -DTXSID6045741 Clint NA 0.2282 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045741 Fup NA 0.0686 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045741 Vd NA 0.9344 L/kg 1compartment NA NA Rat Human -DTXSID6045741 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID6045741 TK.Half.Life NA 26.14 hours 1compartment NA NA Rat Human -DTXSID6045741 Css NA 4.214 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045741 Css NA 15.58 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045741 Css NA 2.528 mg/L PBTK NA 50% Rat Human -DTXSID6045741 Css NA 8.678 mg/L PBTK NA 95% Rat Human -DTXSID6045743 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045743 Fup NA 0.6074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045743 Vd NA 0.6542 L/kg 1compartment NA NA Human Human +DTXSID6045668 TK.Half.Life NA 3.151 hours 1compartment NA NA Rat Human +DTXSID6045668 Css NA 0.01106 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045668 Css NA 0.06674 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045668 Css NA 0.008023 mg/L PBTK NA 50% Rat Human +DTXSID6045668 Css NA 0.0484 mg/L PBTK NA 95% Rat Human +DTXSID6045741 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045741 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045741 Vd NA 2.331 L/kg 1compartment NA NA Human Human +DTXSID6045741 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045741 TK.Half.Life NA 6.472 hours 1compartment NA NA Human Human +DTXSID6045741 Css NA 0.2544 mg/L 3compartmentss NA 50% Human Human +DTXSID6045741 Css NA 1.726 mg/L 3compartmentss NA 95% Human Human +DTXSID6045741 Css NA 0.1796 mg/L PBTK NA 50% Human Human +DTXSID6045741 Css NA 1.185 mg/L PBTK NA 95% Human Human +DTXSID6045741 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045741 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045741 Vd NA 1.774 L/kg 1compartment NA NA Rat Human +DTXSID6045741 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6045741 TK.Half.Life NA 1.919 hours 1compartment NA NA Rat Human +DTXSID6045741 Css NA 0.03249 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045741 Css NA 0.1682 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045741 Css NA 0.02283 mg/L PBTK NA 50% Rat Human +DTXSID6045741 Css NA 0.1124 mg/L PBTK NA 95% Rat Human +DTXSID6045743 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045743 Fup 0.76 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045743 Vd NA 0.7472 L/kg 1compartment NA NA Human Human DTXSID6045743 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045743 TK.Half.Life NA 6.982 hours 1compartment NA NA Human Human -DTXSID6045743 Css NA 1.228 mg/L 3compartmentss NA 50% Human Human -DTXSID6045743 Css NA 8.136 mg/L 3compartmentss NA 95% Human Human -DTXSID6045743 Css NA 0.9707 mg/L PBTK NA 50% Human Human -DTXSID6045743 Css NA 5.083 mg/L PBTK NA 95% Human Human -DTXSID6045743 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045743 Fup NA 0.6074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045743 Vd NA 0.6701 L/kg 1compartment NA NA Rat Human +DTXSID6045743 TK.Half.Life NA 6.377 hours 1compartment NA NA Human Human +DTXSID6045743 Css NA 0.5562 mg/L 3compartmentss NA 50% Human Human +DTXSID6045743 Css NA 3.486 mg/L 3compartmentss NA 95% Human Human +DTXSID6045743 Css NA 0.4622 mg/L PBTK NA 50% Human Human +DTXSID6045743 Css NA 2.289 mg/L PBTK NA 95% Human Human +DTXSID6045743 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045743 Fup 0.76 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045743 Vd NA 0.7663 L/kg 1compartment NA NA Rat Human DTXSID6045743 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045743 TK.Half.Life NA 2.433 hours 1compartment NA NA Rat Human -DTXSID6045743 Css NA 0.3217 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045743 Css NA 2.094 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045743 Css NA 0.2445 mg/L PBTK NA 50% Rat Human -DTXSID6045743 Css NA 1.223 mg/L PBTK NA 95% Rat Human -DTXSID6045745 Clint NA 35.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045745 Fup NA 0.1087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045745 Vd NA 2.724 L/kg 1compartment NA NA Human Human +DTXSID6045743 TK.Half.Life NA 2.224 hours 1compartment NA NA Rat Human +DTXSID6045743 Css NA 0.002871 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045743 Css NA 0.01995 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045743 Css NA 0.002306 mg/L PBTK NA 50% Rat Human +DTXSID6045743 Css NA 0.01251 mg/L PBTK NA 95% Rat Human +DTXSID6045745 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045745 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045745 Vd NA 2.194 L/kg 1compartment NA NA Human Human DTXSID6045745 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045745 TK.Half.Life NA 6.736 hours 1compartment NA NA Human Human -DTXSID6045745 Css NA 0.2326 mg/L 3compartmentss NA 50% Human Human -DTXSID6045745 Css NA 1.607 mg/L 3compartmentss NA 95% Human Human -DTXSID6045745 Css NA 0.1715 mg/L PBTK NA 50% Human Human -DTXSID6045745 Css NA 1.114 mg/L PBTK NA 95% Human Human -DTXSID6045745 Clint NA 35.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045745 Fup NA 0.1087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045745 Vd NA 2.203 L/kg 1compartment NA NA Rat Human +DTXSID6045745 TK.Half.Life NA 12.01 hours 1compartment NA NA Human Human +DTXSID6045745 Css NA 0.6139 mg/L 3compartmentss NA 50% Human Human +DTXSID6045745 Css NA 4.082 mg/L 3compartmentss NA 95% Human Human +DTXSID6045745 Css NA 0.4674 mg/L PBTK NA 50% Human Human +DTXSID6045745 Css NA 2.766 mg/L PBTK NA 95% Human Human +DTXSID6045745 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045745 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045745 Vd NA 1.901 L/kg 1compartment NA NA Rat Human DTXSID6045745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045745 TK.Half.Life NA 2.157 hours 1compartment NA NA Rat Human -DTXSID6045745 Css NA 0.1278 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045745 Css NA 0.7323 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045745 Css NA 0.09104 mg/L PBTK NA 50% Rat Human -DTXSID6045745 Css NA 0.4877 mg/L PBTK NA 95% Rat Human -DTXSID6045749 Clint NA 9.124 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045749 Fup NA 0.6545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045749 Vd NA 3.409 L/kg 1compartment NA NA Human Human -DTXSID6045749 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045749 TK.Half.Life NA 3.105 hours 1compartment NA NA Human Human -DTXSID6045749 Css NA 0.04568 mg/L 3compartmentss NA 50% Human Human -DTXSID6045749 Css NA 0.5586 mg/L 3compartmentss NA 95% Human Human -DTXSID6045749 Css NA 0.05876 mg/L PBTK NA 50% Human Human -DTXSID6045749 Css NA 0.47 mg/L PBTK NA 95% Human Human -DTXSID6045749 Clint NA 9.124 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045749 Fup NA 0.6545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045749 Vd NA 3.417 L/kg 1compartment NA NA Rat Human +DTXSID6045745 TK.Half.Life NA 5.169 hours 1compartment NA NA Rat Human +DTXSID6045745 Css NA 0.07289 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045745 Css NA 0.3692 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045745 Css NA 0.05555 mg/L PBTK NA 50% Rat Human +DTXSID6045745 Css NA 0.2444 mg/L PBTK NA 95% Rat Human +DTXSID6045749 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045749 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045749 Vd NA 1.368 L/kg 1compartment NA NA Human Human +DTXSID6045749 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6045749 TK.Half.Life NA 22.18 hours 1compartment NA NA Human Human +DTXSID6045749 Css NA 1.308 mg/L 3compartmentss NA 50% Human Human +DTXSID6045749 Css NA 6.626 mg/L 3compartmentss NA 95% Human Human +DTXSID6045749 Css NA 1.144 mg/L PBTK NA 50% Human Human +DTXSID6045749 Css NA 4.535 mg/L PBTK NA 95% Human Human +DTXSID6045749 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045749 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045749 Vd NA 1.357 L/kg 1compartment NA NA Rat Human DTXSID6045749 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045749 TK.Half.Life NA 1.743 hours 1compartment NA NA Rat Human -DTXSID6045749 Css NA 0.02142 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045749 Css NA 0.2375 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045749 Css NA 0.02863 mg/L PBTK NA 50% Rat Human -DTXSID6045749 Css NA 0.1871 mg/L PBTK NA 95% Rat Human -DTXSID6045791 Clint NA 10.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045791 Fup NA 0.06 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045791 Vd NA 2.037 L/kg 1compartment NA NA Human Human +DTXSID6045749 TK.Half.Life NA 7.501 hours 1compartment NA NA Rat Human +DTXSID6045749 Css NA 0.03098 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045749 Css NA 0.2081 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045749 Css NA 0.02724 mg/L PBTK NA 50% Rat Human +DTXSID6045749 Css NA 0.1448 mg/L PBTK NA 95% Rat Human +DTXSID6045791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045791 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045791 Vd NA 0.9847 L/kg 1compartment NA NA Human Human DTXSID6045791 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045791 TK.Half.Life NA 5.291 hours 1compartment NA NA Human Human -DTXSID6045791 Css NA 0.2652 mg/L 3compartmentss NA 50% Human Human -DTXSID6045791 Css NA 2.423 mg/L 3compartmentss NA 95% Human Human -DTXSID6045791 Css NA 0.22 mg/L PBTK NA 50% Human Human -DTXSID6045791 Css NA 1.672 mg/L PBTK NA 95% Human Human -DTXSID6045791 Clint NA 10.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045791 Fup NA 0.06 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045791 Vd NA 1.99 L/kg 1compartment NA NA Rat Human +DTXSID6045791 TK.Half.Life NA 1.514 hours 1compartment NA NA Human Human +DTXSID6045791 Css NA 0.09434 mg/L 3compartmentss NA 50% Human Human +DTXSID6045791 Css NA 0.6847 mg/L 3compartmentss NA 95% Human Human +DTXSID6045791 Css NA 0.06982 mg/L PBTK NA 50% Human Human +DTXSID6045791 Css NA 0.4727 mg/L PBTK NA 95% Human Human +DTXSID6045791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045791 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045791 Vd NA 0.968 L/kg 1compartment NA NA Rat Human DTXSID6045791 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045791 TK.Half.Life NA 3.172 hours 1compartment NA NA Rat Human -DTXSID6045791 Css NA 0.1478 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045791 Css NA 1.104 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045791 Css NA 0.1168 mg/L PBTK NA 50% Rat Human -DTXSID6045791 Css NA 0.737 mg/L PBTK NA 95% Rat Human -DTXSID6045795 Clint NA 4.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045795 Fup NA 0.2956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045795 Vd NA 0.8365 L/kg 1compartment NA NA Human Human +DTXSID6045791 TK.Half.Life NA 0.8324 hours 1compartment NA NA Rat Human +DTXSID6045791 Css NA 0.01195 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045791 Css NA 0.06466 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045791 Css NA 0.00879 mg/L PBTK NA 50% Rat Human +DTXSID6045791 Css NA 0.04382 mg/L PBTK NA 95% Rat Human +DTXSID6045795 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045795 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045795 Vd NA 0.9112 L/kg 1compartment NA NA Human Human DTXSID6045795 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045795 TK.Half.Life NA 2.536 hours 1compartment NA NA Human Human -DTXSID6045795 Css NA 0.2872 mg/L 3compartmentss NA 50% Human Human -DTXSID6045795 Css NA 1.729 mg/L 3compartmentss NA 95% Human Human -DTXSID6045795 Css NA 0.2108 mg/L PBTK NA 50% Human Human -DTXSID6045795 Css NA 1.146 mg/L PBTK NA 95% Human Human -DTXSID6045795 Clint NA 4.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045795 Fup NA 0.2956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045795 Vd NA 0.7429 L/kg 1compartment NA NA Rat Human +DTXSID6045795 TK.Half.Life NA 1.154 hours 1compartment NA NA Human Human +DTXSID6045795 Css NA 0.06348 mg/L 3compartmentss NA 50% Human Human +DTXSID6045795 Css NA 0.5023 mg/L 3compartmentss NA 95% Human Human +DTXSID6045795 Css NA 0.04684 mg/L PBTK NA 50% Human Human +DTXSID6045795 Css NA 0.3373 mg/L PBTK NA 95% Human Human +DTXSID6045795 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045795 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045795 Vd NA 0.802 L/kg 1compartment NA NA Rat Human DTXSID6045795 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045795 TK.Half.Life NA 1.257 hours 1compartment NA NA Rat Human -DTXSID6045795 Css NA 0.1456 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045795 Css NA 0.633 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045795 Css NA 0.1021 mg/L PBTK NA 50% Rat Human -DTXSID6045795 Css NA 0.3878 mg/L PBTK NA 95% Rat Human -DTXSID6045820 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045820 Fup NA 0.1799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045820 Vd NA 0.2922 L/kg 1compartment NA NA Human Human -DTXSID6045820 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6045820 TK.Half.Life NA 10.52 hours 1compartment NA NA Human Human -DTXSID6045820 Css NA 4.549 mg/L 3compartmentss NA 50% Human Human -DTXSID6045820 Css NA 16.24 mg/L 3compartmentss NA 95% Human Human -DTXSID6045820 Css NA 2.89 mg/L PBTK NA 50% Human Human -DTXSID6045820 Css NA 9.81 mg/L PBTK NA 95% Human Human -DTXSID6045820 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045820 Fup NA 0.1799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045820 Vd NA 0.2918 L/kg 1compartment NA NA Rat Human +DTXSID6045795 TK.Half.Life NA 0.5279 hours 1compartment NA NA Rat Human +DTXSID6045795 Css NA 0.007978 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045795 Css NA 0.04797 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045795 Css NA 0.005906 mg/L PBTK NA 50% Rat Human +DTXSID6045795 Css NA 0.03227 mg/L PBTK NA 95% Rat Human +DTXSID6045820 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045820 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045820 Vd NA 0.3374 L/kg 1compartment NA NA Human Human +DTXSID6045820 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045820 TK.Half.Life NA 0.9208 hours 1compartment NA NA Human Human +DTXSID6045820 Css NA 0.1318 mg/L 3compartmentss NA 50% Human Human +DTXSID6045820 Css NA 0.8945 mg/L 3compartmentss NA 95% Human Human +DTXSID6045820 Css NA 0.08674 mg/L PBTK NA 50% Human Human +DTXSID6045820 Css NA 0.5585 mg/L PBTK NA 95% Human Human +DTXSID6045820 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045820 Fup 0.28 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045820 Vd NA 0.3396 L/kg 1compartment NA NA Rat Human DTXSID6045820 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045820 TK.Half.Life NA 3.577 hours 1compartment NA NA Rat Human -DTXSID6045820 Css NA 1.285 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045820 Css NA 3.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045820 Css NA 0.7701 mg/L PBTK NA 50% Rat Human -DTXSID6045820 Css NA 2.122 mg/L PBTK NA 95% Rat Human -DTXSID6045828 Clint NA 19.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045828 Fup NA 0.3996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045828 Vd NA 4.124 L/kg 1compartment NA NA Human Human +DTXSID6045820 TK.Half.Life NA 0.5295 hours 1compartment NA NA Rat Human +DTXSID6045820 Css NA 0.001271 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045820 Css NA 0.007283 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045820 Css NA 0.0007987 mg/L PBTK NA 50% Rat Human +DTXSID6045820 Css NA 0.004347 mg/L PBTK NA 95% Rat Human +DTXSID6045828 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045828 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045828 Vd NA 3.449 L/kg 1compartment NA NA Human Human DTXSID6045828 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045828 TK.Half.Life NA 3.328 hours 1compartment NA NA Human Human -DTXSID6045828 Css NA 0.02932 mg/L 3compartmentss NA 50% Human Human -DTXSID6045828 Css NA 0.2709 mg/L 3compartmentss NA 95% Human Human -DTXSID6045828 Css NA 0.03854 mg/L PBTK NA 50% Human Human -DTXSID6045828 Css NA 0.2745 mg/L PBTK NA 95% Human Human -DTXSID6045828 Clint NA 19.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045828 Fup NA 0.3996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045828 Vd NA 4.194 L/kg 1compartment NA NA Rat Human +DTXSID6045828 TK.Half.Life NA 5.545 hours 1compartment NA NA Human Human +DTXSID6045828 Css NA 0.08847 mg/L 3compartmentss NA 50% Human Human +DTXSID6045828 Css NA 0.7315 mg/L 3compartmentss NA 95% Human Human +DTXSID6045828 Css NA 0.106 mg/L PBTK NA 50% Human Human +DTXSID6045828 Css NA 0.6414 mg/L PBTK NA 95% Human Human +DTXSID6045828 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045828 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045828 Vd NA 3.507 L/kg 1compartment NA NA Rat Human DTXSID6045828 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045828 TK.Half.Life NA 1.852 hours 1compartment NA NA Rat Human -DTXSID6045828 Css NA 0.01499 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045828 Css NA 0.1129 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045828 Css NA 0.02008 mg/L PBTK NA 50% Rat Human -DTXSID6045828 Css NA 0.1054 mg/L PBTK NA 95% Rat Human -DTXSID6045870 Clint NA 0.6587 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045870 Fup NA 0.5029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045870 Vd NA 0.4752 L/kg 1compartment NA NA Human Human +DTXSID6045828 TK.Half.Life NA 3.262 hours 1compartment NA NA Rat Human +DTXSID6045828 Css NA 0.00993 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045828 Css NA 0.06791 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045828 Css NA 0.01258 mg/L PBTK NA 50% Rat Human +DTXSID6045828 Css NA 0.05765 mg/L PBTK NA 95% Rat Human +DTXSID6045870 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045870 Fup 0.743 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045870 Vd NA 0.7476 L/kg 1compartment NA NA Human Human DTXSID6045870 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045870 TK.Half.Life NA 2.948 hours 1compartment NA NA Human Human -DTXSID6045870 Css NA 0.6946 mg/L 3compartmentss NA 50% Human Human -DTXSID6045870 Css NA 3.64 mg/L 3compartmentss NA 95% Human Human -DTXSID6045870 Css NA 0.5181 mg/L PBTK NA 50% Human Human -DTXSID6045870 Css NA 2.288 mg/L PBTK NA 95% Human Human -DTXSID6045870 Clint NA 0.6587 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045870 Fup NA 0.5029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045870 Vd NA 0.4877 L/kg 1compartment NA NA Rat Human +DTXSID6045870 TK.Half.Life NA 6.508 hours 1compartment NA NA Human Human +DTXSID6045870 Css NA 0.9677 mg/L 3compartmentss NA 50% Human Human +DTXSID6045870 Css NA 6.255 mg/L 3compartmentss NA 95% Human Human +DTXSID6045870 Css NA 0.8243 mg/L PBTK NA 50% Human Human +DTXSID6045870 Css NA 4.06 mg/L PBTK NA 95% Human Human +DTXSID6045870 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045870 Fup 0.743 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045870 Vd NA 0.7547 L/kg 1compartment NA NA Rat Human DTXSID6045870 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045870 TK.Half.Life NA 1.394 hours 1compartment NA NA Rat Human -DTXSID6045870 Css NA 0.2597 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045870 Css NA 1.229 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045870 Css NA 0.1844 mg/L PBTK NA 50% Rat Human -DTXSID6045870 Css NA 0.7198 mg/L PBTK NA 95% Rat Human -DTXSID6045872 Clint NA 0.1506 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045872 Fup NA 0.1848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045872 Vd NA 0.3129 L/kg 1compartment NA NA Human Human +DTXSID6045870 TK.Half.Life NA 2.24 hours 1compartment NA NA Rat Human +DTXSID6045870 Css NA 0.05723 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045870 Css NA 0.3694 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045870 Css NA 0.04936 mg/L PBTK NA 50% Rat Human +DTXSID6045870 Css NA 0.2308 mg/L PBTK NA 95% Rat Human +DTXSID6045872 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045872 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045872 Vd NA 0.3794 L/kg 1compartment NA NA Human Human DTXSID6045872 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045872 TK.Half.Life NA 8.777 hours 1compartment NA NA Human Human -DTXSID6045872 Css NA 3.488 mg/L 3compartmentss NA 50% Human Human -DTXSID6045872 Css NA 12.96 mg/L 3compartmentss NA 95% Human Human -DTXSID6045872 Css NA 2.254 mg/L PBTK NA 50% Human Human -DTXSID6045872 Css NA 7.755 mg/L PBTK NA 95% Human Human -DTXSID6045872 Clint NA 0.1506 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045872 Fup NA 0.1848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045872 Vd NA 0.3122 L/kg 1compartment NA NA Rat Human +DTXSID6045872 TK.Half.Life NA 1.012 hours 1compartment NA NA Human Human +DTXSID6045872 Css NA 0.1235 mg/L 3compartmentss NA 50% Human Human +DTXSID6045872 Css NA 0.9155 mg/L 3compartmentss NA 95% Human Human +DTXSID6045872 Css NA 0.08404 mg/L PBTK NA 50% Human Human +DTXSID6045872 Css NA 0.5804 mg/L PBTK NA 95% Human Human +DTXSID6045872 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045872 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045872 Vd NA 0.3795 L/kg 1compartment NA NA Rat Human DTXSID6045872 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045872 TK.Half.Life NA 3.323 hours 1compartment NA NA Rat Human -DTXSID6045872 Css NA 1.113 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045872 Css NA 3.442 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045872 Css NA 0.6762 mg/L PBTK NA 50% Rat Human -DTXSID6045872 Css NA 1.94 mg/L PBTK NA 95% Rat Human -DTXSID6045874 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045874 Fup NA 0.2397 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045874 Vd NA 0.2836 L/kg 1compartment NA NA Human Human -DTXSID6045874 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045874 TK.Half.Life NA 7.655 hours 1compartment NA NA Human Human -DTXSID6045874 Css NA 3.457 mg/L 3compartmentss NA 50% Human Human -DTXSID6045874 Css NA 12.53 mg/L 3compartmentss NA 95% Human Human -DTXSID6045874 Css NA 2.214 mg/L PBTK NA 50% Human Human -DTXSID6045874 Css NA 7.594 mg/L PBTK NA 95% Human Human -DTXSID6045874 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045874 Fup NA 0.2397 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045874 Vd NA 0.2916 L/kg 1compartment NA NA Rat Human +DTXSID6045872 TK.Half.Life NA 0.5791 hours 1compartment NA NA Rat Human +DTXSID6045872 Css NA 0.001213 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045872 Css NA 0.007312 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045872 Css NA 0.0007883 mg/L PBTK NA 50% Rat Human +DTXSID6045872 Css NA 0.004349 mg/L PBTK NA 95% Rat Human +DTXSID6045874 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045874 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045874 Vd NA 0.2944 L/kg 1compartment NA NA Human Human +DTXSID6045874 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6045874 TK.Half.Life NA 10.95 hours 1compartment NA NA Human Human +DTXSID6045874 Css NA 2.558 mg/L 3compartmentss NA 50% Human Human +DTXSID6045874 Css NA 9.772 mg/L 3compartmentss NA 95% Human Human +DTXSID6045874 Css NA 1.617 mg/L PBTK NA 50% Human Human +DTXSID6045874 Css NA 5.93 mg/L PBTK NA 95% Human Human +DTXSID6045874 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045874 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045874 Vd NA 0.2931 L/kg 1compartment NA NA Rat Human DTXSID6045874 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045874 TK.Half.Life NA 2.682 hours 1compartment NA NA Rat Human -DTXSID6045874 Css NA 0.9571 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045874 Css NA 2.881 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045874 Css NA 0.5758 mg/L PBTK NA 50% Rat Human -DTXSID6045874 Css NA 1.618 mg/L PBTK NA 95% Rat Human -DTXSID6045878 Clint NA 0.08229 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045878 Fup NA 0.0652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045878 Vd NA 0.2793 L/kg 1compartment NA NA Human Human -DTXSID6045878 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6045878 TK.Half.Life NA 24.38 hours 1compartment NA NA Human Human -DTXSID6045878 Css NA 13.66 mg/L 3compartmentss NA 50% Human Human -DTXSID6045878 Css NA 58.35 mg/L 3compartmentss NA 95% Human Human -DTXSID6045878 Css NA 8.321 mg/L PBTK NA 50% Human Human -DTXSID6045878 Css NA 33.81 mg/L PBTK NA 95% Human Human -DTXSID6045878 Clint NA 0.08229 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045878 Fup NA 0.0652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045878 Vd NA 0.2768 L/kg 1compartment NA NA Rat Human +DTXSID6045874 TK.Half.Life NA 3.715 hours 1compartment NA NA Rat Human +DTXSID6045874 Css NA 0.01397 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045874 Css NA 0.05402 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045874 Css NA 0.008334 mg/L PBTK NA 50% Rat Human +DTXSID6045874 Css NA 0.03074 mg/L PBTK NA 95% Rat Human +DTXSID6045878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045878 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045878 Vd NA 0.4179 L/kg 1compartment NA NA Human Human +DTXSID6045878 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045878 TK.Half.Life NA 0.7718 hours 1compartment NA NA Human Human +DTXSID6045878 Css NA 0.1409 mg/L 3compartmentss NA 50% Human Human +DTXSID6045878 Css NA 1.015 mg/L 3compartmentss NA 95% Human Human +DTXSID6045878 Css NA 0.09331 mg/L PBTK NA 50% Human Human +DTXSID6045878 Css NA 0.632 mg/L PBTK NA 95% Human Human +DTXSID6045878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045878 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045878 Vd NA 0.4169 L/kg 1compartment NA NA Rat Human DTXSID6045878 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045878 TK.Half.Life NA 8.777 hours 1compartment NA NA Rat Human -DTXSID6045878 Css NA 4.214 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045878 Css NA 15.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045878 Css NA 2.406 mg/L PBTK NA 50% Rat Human -DTXSID6045878 Css NA 8.348 mg/L PBTK NA 95% Rat Human -DTXSID6045901 Clint NA 10.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045901 Fup NA 0.4889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045901 Vd NA 0.8473 L/kg 1compartment NA NA Human Human +DTXSID6045878 TK.Half.Life NA 0.4365 hours 1compartment NA NA Rat Human +DTXSID6045878 Css NA 0.01799 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045878 Css NA 0.102 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045878 Css NA 0.01178 mg/L PBTK NA 50% Rat Human +DTXSID6045878 Css NA 0.06285 mg/L PBTK NA 95% Rat Human +DTXSID6045901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045901 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045901 Vd NA 0.6624 L/kg 1compartment NA NA Human Human DTXSID6045901 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045901 TK.Half.Life NA 1.143 hours 1compartment NA NA Human Human -DTXSID6045901 Css NA 0.08838 mg/L 3compartmentss NA 50% Human Human -DTXSID6045901 Css NA 0.6847 mg/L 3compartmentss NA 95% Human Human -DTXSID6045901 Css NA 0.06814 mg/L PBTK NA 50% Human Human -DTXSID6045901 Css NA 0.466 mg/L PBTK NA 95% Human Human -DTXSID6045901 Clint NA 10.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045901 Fup NA 0.4889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045901 Vd NA 0.7785 L/kg 1compartment NA NA Rat Human +DTXSID6045901 TK.Half.Life NA 0.8501 hours 1compartment NA NA Human Human +DTXSID6045901 Css NA 0.06385 mg/L 3compartmentss NA 50% Human Human +DTXSID6045901 Css NA 0.4841 mg/L 3compartmentss NA 95% Human Human +DTXSID6045901 Css NA 0.04543 mg/L PBTK NA 50% Human Human +DTXSID6045901 Css NA 0.3168 mg/L PBTK NA 95% Human Human +DTXSID6045901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045901 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045901 Vd NA 0.6066 L/kg 1compartment NA NA Rat Human DTXSID6045901 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045901 TK.Half.Life NA 0.5559 hours 1compartment NA NA Rat Human -DTXSID6045901 Css NA 0.04458 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045901 Css NA 0.2805 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045901 Css NA 0.03329 mg/L PBTK NA 50% Rat Human -DTXSID6045901 Css NA 0.1797 mg/L PBTK NA 95% Rat Human -DTXSID6045903 Clint NA 128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045903 Fup NA 0.0229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045903 Vd NA 0.3501 L/kg 1compartment NA NA Human Human -DTXSID6045903 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045903 TK.Half.Life NA 0.7756 hours 1compartment NA NA Human Human -DTXSID6045903 Css NA 0.2412 mg/L 3compartmentss NA 50% Human Human -DTXSID6045903 Css NA 2.438 mg/L 3compartmentss NA 95% Human Human -DTXSID6045903 Css NA 0.1435 mg/L PBTK NA 50% Human Human -DTXSID6045903 Css NA 1.421 mg/L PBTK NA 95% Human Human -DTXSID6045903 Clint NA 128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045903 Fup NA 0.0229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045903 Vd NA 0.2883 L/kg 1compartment NA NA Rat Human -DTXSID6045903 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045903 TK.Half.Life NA 0.3705 hours 1compartment NA NA Rat Human -DTXSID6045903 Css NA 0.143 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045903 Css NA 1.191 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045903 Css NA 0.07898 mg/L PBTK NA 50% Rat Human -DTXSID6045903 Css NA 0.651 mg/L PBTK NA 95% Rat Human -DTXSID6045905 Clint NA 45.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045905 Fup NA 0.0755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045905 Vd NA 1.273 L/kg 1compartment NA NA Human Human +DTXSID6045901 TK.Half.Life NA 0.4077 hours 1compartment NA NA Rat Human +DTXSID6045901 Css NA 0.008195 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045901 Css NA 0.04763 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045901 Css NA 0.0058 mg/L PBTK NA 50% Rat Human +DTXSID6045901 Css NA 0.03155 mg/L PBTK NA 95% Rat Human +DTXSID6045905 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045905 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045905 Vd NA 0.4923 L/kg 1compartment NA NA Human Human DTXSID6045905 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045905 TK.Half.Life NA 2.601 hours 1compartment NA NA Human Human -DTXSID6045905 Css NA 0.1959 mg/L 3compartmentss NA 50% Human Human -DTXSID6045905 Css NA 1.618 mg/L 3compartmentss NA 95% Human Human -DTXSID6045905 Css NA 0.1275 mg/L PBTK NA 50% Human Human -DTXSID6045905 Css NA 1.007 mg/L PBTK NA 95% Human Human -DTXSID6045905 Clint NA 45.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045905 Fup NA 0.0755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045905 Vd NA 0.9683 L/kg 1compartment NA NA Rat Human +DTXSID6045905 TK.Half.Life NA 0.9647 hours 1compartment NA NA Human Human +DTXSID6045905 Css NA 0.168 mg/L 3compartmentss NA 50% Human Human +DTXSID6045905 Css NA 1.309 mg/L 3compartmentss NA 95% Human Human +DTXSID6045905 Css NA 0.1081 mg/L PBTK NA 50% Human Human +DTXSID6045905 Css NA 0.8009 mg/L PBTK NA 95% Human Human +DTXSID6045905 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045905 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045905 Vd NA 0.4337 L/kg 1compartment NA NA Rat Human DTXSID6045905 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045905 TK.Half.Life NA 1.022 hours 1compartment NA NA Rat Human -DTXSID6045905 Css NA 0.1123 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045905 Css NA 0.688 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045905 Css NA 0.06859 mg/L PBTK NA 50% Rat Human -DTXSID6045905 Css NA 0.4073 mg/L PBTK NA 95% Rat Human -DTXSID6045907 Clint NA 3.879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045907 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045907 Vd NA 2.08 L/kg 1compartment NA NA Human Human -DTXSID6045907 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID6045907 TK.Half.Life NA 56.58 hours 1compartment NA NA Human Human -DTXSID6045907 Css NA 4.086 mg/L 3compartmentss NA 50% Human Human -DTXSID6045907 Css NA 22.3 mg/L 3compartmentss NA 95% Human Human -DTXSID6045907 Css NA 2.702 mg/L PBTK NA 50% Human Human -DTXSID6045907 Css NA 14.04 mg/L PBTK NA 95% Human Human -DTXSID6045907 Clint NA 3.879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045907 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045907 Vd NA 1.561 L/kg 1compartment NA NA Rat Human -DTXSID6045907 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID6045907 TK.Half.Life NA 16.6 hours 1compartment NA NA Rat Human -DTXSID6045907 Css NA 2.13 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045907 Css NA 8.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045907 Css NA 1.324 mg/L PBTK NA 50% Rat Human -DTXSID6045907 Css NA 4.936 mg/L PBTK NA 95% Rat Human -DTXSID6045909 Clint NA 17.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045909 Fup NA 0.2425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045909 Vd NA 2.247 L/kg 1compartment NA NA Human Human +DTXSID6045905 TK.Half.Life NA 0.48 hours 1compartment NA NA Rat Human +DTXSID6045905 Css NA 0.02184 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045905 Css NA 0.1281 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045905 Css NA 0.01374 mg/L PBTK NA 50% Rat Human +DTXSID6045905 Css NA 0.07617 mg/L PBTK NA 95% Rat Human +DTXSID6045907 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045907 Fup 0.0847 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045907 Vd NA 2.456 L/kg 1compartment NA NA Human Human +DTXSID6045907 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6045907 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human +DTXSID6045907 Css NA 0.5486 mg/L 3compartmentss NA 50% Human Human +DTXSID6045907 Css NA 3.692 mg/L 3compartmentss NA 95% Human Human +DTXSID6045907 Css NA 0.3746 mg/L PBTK NA 50% Human Human +DTXSID6045907 Css NA 2.415 mg/L PBTK NA 95% Human Human +DTXSID6045907 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045907 Fup 0.0847 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045907 Vd NA 1.852 L/kg 1compartment NA NA Rat Human +DTXSID6045907 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6045907 TK.Half.Life NA 3.144 hours 1compartment NA NA Rat Human +DTXSID6045907 Css NA 0.07012 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045907 Css NA 0.3923 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045907 Css NA 0.04708 mg/L PBTK NA 50% Rat Human +DTXSID6045907 Css NA 0.2504 mg/L PBTK NA 95% Rat Human +DTXSID6045909 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045909 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045909 Vd NA 2.813 L/kg 1compartment NA NA Human Human DTXSID6045909 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045909 TK.Half.Life NA 3.19 hours 1compartment NA NA Human Human -DTXSID6045909 Css NA 0.08384 mg/L 3compartmentss NA 50% Human Human -DTXSID6045909 Css NA 0.6262 mg/L 3compartmentss NA 95% Human Human -DTXSID6045909 Css NA 0.07568 mg/L PBTK NA 50% Human Human -DTXSID6045909 Css NA 0.4852 mg/L PBTK NA 95% Human Human -DTXSID6045909 Clint NA 17.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045909 Fup NA 0.2425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045909 Vd NA 2.2 L/kg 1compartment NA NA Rat Human +DTXSID6045909 TK.Half.Life NA 3.339 hours 1compartment NA NA Human Human +DTXSID6045909 Css NA 0.05739 mg/L 3compartmentss NA 50% Human Human +DTXSID6045909 Css NA 0.4478 mg/L 3compartmentss NA 95% Human Human +DTXSID6045909 Css NA 0.0556 mg/L PBTK NA 50% Human Human +DTXSID6045909 Css NA 0.3715 mg/L PBTK NA 95% Human Human +DTXSID6045909 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045909 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045909 Vd NA 2.714 L/kg 1compartment NA NA Rat Human DTXSID6045909 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045909 TK.Half.Life NA 1.723 hours 1compartment NA NA Rat Human -DTXSID6045909 Css NA 0.04418 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045909 Css NA 0.2558 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045909 Css NA 0.03908 mg/L PBTK NA 50% Rat Human -DTXSID6045909 Css NA 0.1921 mg/L PBTK NA 95% Rat Human -DTXSID6045951 Clint NA 13.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6045909 TK.Half.Life NA 1.686 hours 1compartment NA NA Rat Human +DTXSID6045909 Css NA 0.007108 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045909 Css NA 0.04222 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045909 Css NA 0.007052 mg/L PBTK NA 50% Rat Human +DTXSID6045909 Css NA 0.03617 mg/L PBTK NA 95% Rat Human +DTXSID6045951 Clint 12 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID6045951 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6045951 Vd NA 2.353 L/kg 1compartment NA NA Human Human +DTXSID6045951 Vd NA 2.325 L/kg 1compartment NA NA Human Human DTXSID6045951 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045951 TK.Half.Life NA 8.131 hours 1compartment NA NA Human Human -DTXSID6045951 Css NA 0.3305 mg/L 3compartmentss NA 50% Human Human -DTXSID6045951 Css NA 1.941 mg/L 3compartmentss NA 95% Human Human -DTXSID6045951 Css NA 0.2391 mg/L PBTK NA 50% Human Human -DTXSID6045951 Css NA 1.352 mg/L PBTK NA 95% Human Human -DTXSID6045951 Clint NA 13.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6045951 TK.Half.Life NA 4.519 hours 1compartment NA NA Human Human +DTXSID6045951 Css NA 0.1288 mg/L 3compartmentss NA 50% Human Human +DTXSID6045951 Css NA 0.9507 mg/L 3compartmentss NA 95% Human Human +DTXSID6045951 Css NA 0.1185 mg/L PBTK NA 50% Human Human +DTXSID6045951 Css NA 0.7498 mg/L PBTK NA 95% Human Human +DTXSID6045951 Clint 12 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID6045951 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6045951 Vd NA 1.798 L/kg 1compartment NA NA Rat Human +DTXSID6045951 Vd NA 2.338 L/kg 1compartment NA NA Rat Human DTXSID6045951 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045951 TK.Half.Life NA 2.362 hours 1compartment NA NA Rat Human -DTXSID6045951 Css NA 0.1792 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045951 Css NA 0.7871 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045951 Css NA 0.1248 mg/L PBTK NA 50% Rat Human -DTXSID6045951 Css NA 0.5241 mg/L PBTK NA 95% Rat Human -DTXSID6045953 Clint NA 20.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045953 Fup NA 0.154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045953 Vd NA 2.198 L/kg 1compartment NA NA Human Human +DTXSID6045951 TK.Half.Life NA 2.687 hours 1compartment NA NA Rat Human +DTXSID6045951 Css NA 0.01532 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045951 Css NA 0.08591 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045951 Css NA 0.01456 mg/L PBTK NA 50% Rat Human +DTXSID6045951 Css NA 0.06731 mg/L PBTK NA 95% Rat Human +DTXSID6045953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045953 Fup 0.0896 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045953 Vd NA 0.7686 L/kg 1compartment NA NA Human Human DTXSID6045953 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045953 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human -DTXSID6045953 Css NA 0.2552 mg/L 3compartmentss NA 50% Human Human -DTXSID6045953 Css NA 1.695 mg/L 3compartmentss NA 95% Human Human -DTXSID6045953 Css NA 0.1822 mg/L PBTK NA 50% Human Human -DTXSID6045953 Css NA 1.157 mg/L PBTK NA 95% Human Human -DTXSID6045953 Clint NA 20.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045953 Fup NA 0.154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045953 Vd NA 1.701 L/kg 1compartment NA NA Rat Human +DTXSID6045953 TK.Half.Life NA 2.142 hours 1compartment NA NA Human Human +DTXSID6045953 Css NA 0.2741 mg/L 3compartmentss NA 50% Human Human +DTXSID6045953 Css NA 2.294 mg/L 3compartmentss NA 95% Human Human +DTXSID6045953 Css NA 0.1762 mg/L PBTK NA 50% Human Human +DTXSID6045953 Css NA 1.393 mg/L PBTK NA 95% Human Human +DTXSID6045953 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045953 Fup 0.0896 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045953 Vd NA 0.6114 L/kg 1compartment NA NA Rat Human DTXSID6045953 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045953 TK.Half.Life NA 1.895 hours 1compartment NA NA Rat Human -DTXSID6045953 Css NA 0.1411 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045953 Css NA 0.7195 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045953 Css NA 0.09558 mg/L PBTK NA 50% Rat Human -DTXSID6045953 Css NA 0.4596 mg/L PBTK NA 95% Rat Human -DTXSID6045955 Clint NA 47.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6045953 TK.Half.Life NA 0.9801 hours 1compartment NA NA Rat Human +DTXSID6045953 Css NA 0.01328 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045953 Css NA 0.1234 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045953 Css NA 0.00822 mg/L PBTK NA 50% Rat Human +DTXSID6045953 Css NA 0.07209 mg/L PBTK NA 95% Rat Human +DTXSID6045955 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6045955 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID6045955 Vd NA 0.7311 L/kg 1compartment NA NA Human Human -DTXSID6045955 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045955 TK.Half.Life NA 3.218 hours 1compartment NA NA Human Human -DTXSID6045955 Css NA 0.585 mg/L 3compartmentss NA 50% Human Human -DTXSID6045955 Css NA 6.379 mg/L 3compartmentss NA 95% Human Human -DTXSID6045955 Css NA 0.4114 mg/L PBTK NA 50% Human Human -DTXSID6045955 Css NA 4.003 mg/L PBTK NA 95% Human Human -DTXSID6045955 Clint NA 47.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6045955 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6045955 TK.Half.Life NA 19.6 hours 1compartment NA NA Human Human +DTXSID6045955 Css NA 3.89 mg/L 3compartmentss NA 50% Human Human +DTXSID6045955 Css NA 31.08 mg/L 3compartmentss NA 95% Human Human +DTXSID6045955 Css NA 2.8 mg/L PBTK NA 50% Human Human +DTXSID6045955 Css NA 22.38 mg/L PBTK NA 95% Human Human +DTXSID6045955 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6045955 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID6045955 Vd NA 0.5578 L/kg 1compartment NA NA Rat Human -DTXSID6045955 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045955 TK.Half.Life NA 1.508 hours 1compartment NA NA Rat Human -DTXSID6045955 Css NA 0.3362 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045955 Css NA 2.971 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045955 Css NA 0.2212 mg/L PBTK NA 50% Rat Human -DTXSID6045955 Css NA 1.745 mg/L PBTK NA 95% Rat Human -DTXSID6045957 Clint NA 96.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045957 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045957 Vd NA 2.863 L/kg 1compartment NA NA Human Human +DTXSID6045955 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6045955 TK.Half.Life NA 9.06 hours 1compartment NA NA Rat Human +DTXSID6045955 Css NA 0.4212 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045955 Css NA 2.815 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045955 Css NA 0.3137 mg/L PBTK NA 50% Rat Human +DTXSID6045955 Css NA 2.094 mg/L PBTK NA 95% Rat Human +DTXSID6045957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045957 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6045957 Vd NA 1.713 L/kg 1compartment NA NA Human Human DTXSID6045957 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6045957 TK.Half.Life NA 8.773 hours 1compartment NA NA Human Human -DTXSID6045957 Css NA 0.3166 mg/L 3compartmentss NA 50% Human Human -DTXSID6045957 Css NA 2.132 mg/L 3compartmentss NA 95% Human Human -DTXSID6045957 Css NA 0.216 mg/L PBTK NA 50% Human Human -DTXSID6045957 Css NA 1.389 mg/L PBTK NA 95% Human Human -DTXSID6045957 Clint NA 96.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045957 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045957 Vd NA 2.156 L/kg 1compartment NA NA Rat Human +DTXSID6045957 TK.Half.Life NA 6.856 hours 1compartment NA NA Human Human +DTXSID6045957 Css NA 0.5009 mg/L 3compartmentss NA 50% Human Human +DTXSID6045957 Css NA 4.239 mg/L 3compartmentss NA 95% Human Human +DTXSID6045957 Css NA 0.3405 mg/L PBTK NA 50% Human Human +DTXSID6045957 Css NA 2.685 mg/L PBTK NA 95% Human Human +DTXSID6045957 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045957 Fup 0.0479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6045957 Vd NA 1.458 L/kg 1compartment NA NA Rat Human DTXSID6045957 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6045957 TK.Half.Life NA 1.988 hours 1compartment NA NA Rat Human -DTXSID6045957 Css NA 0.1775 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045957 Css NA 1.067 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045957 Css NA 0.1151 mg/L PBTK NA 50% Rat Human -DTXSID6045957 Css NA 0.6619 mg/L PBTK NA 95% Rat Human +DTXSID6045957 TK.Half.Life NA 3.218 hours 1compartment NA NA Rat Human +DTXSID6045957 Css NA 0.06498 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045957 Css NA 0.4426 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045957 Css NA 0.0434 mg/L PBTK NA 50% Rat Human +DTXSID6045957 Css NA 0.2763 mg/L PBTK NA 95% Rat Human DTXSID6045959 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6045959 Fup NA 0.005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6045959 Vd NA 25.73 L/kg 1compartment NA NA Human Human -DTXSID6045959 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6045959 TK.Half.Life NA 415300 hours 1compartment NA NA Human Human -DTXSID6045959 Css NA 509.2 mg/L 3compartmentss NA 50% Human Human -DTXSID6045959 Css NA 2159 mg/L 3compartmentss NA 95% Human Human -DTXSID6045959 Css NA 1351 mg/L PBTK NA 50% Human Human -DTXSID6045959 Css NA 3635 mg/L PBTK NA 95% Human Human +DTXSID6045959 Vd NA 1.016 L/kg 1compartment NA NA Human Human +DTXSID6045959 Days.Css NA 424 Days PBTK NA NA Human Human +DTXSID6045959 TK.Half.Life NA 1571 hours 1compartment NA NA Human Human +DTXSID6045959 Css NA 222.9 mg/L 3compartmentss NA 50% Human Human +DTXSID6045959 Css NA 1226 mg/L 3compartmentss NA 95% Human Human +DTXSID6045959 Css NA 134.1 mg/L PBTK NA 50% Human Human +DTXSID6045959 Css NA 715.6 mg/L PBTK NA 95% Human Human DTXSID6045959 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6045959 Fup NA 0.005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6045959 Vd NA 21.11 L/kg 1compartment NA NA Rat Human -DTXSID6045959 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6045959 TK.Half.Life NA 34800 hours 1compartment NA NA Rat Human -DTXSID6045959 Css NA 125.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID6045959 Css NA 487.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID6045959 Css NA 350.2 mg/L PBTK NA 50% Rat Human -DTXSID6045959 Css NA 764.3 mg/L PBTK NA 95% Rat Human -DTXSID6046000 Clint NA 10.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046000 Fup NA 0.0669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046000 Vd NA 3.55 L/kg 1compartment NA NA Human Human +DTXSID6045959 Vd NA 0.7448 L/kg 1compartment NA NA Rat Human +DTXSID6045959 Days.Css NA 99 Days PBTK NA NA Rat Human +DTXSID6045959 TK.Half.Life NA 343.7 hours 1compartment NA NA Rat Human +DTXSID6045959 Css NA 5.453 mg/L 3compartmentss NA 50% Rat Human +DTXSID6045959 Css NA 39.46 mg/L 3compartmentss NA 95% Rat Human +DTXSID6045959 Css NA 3.138 mg/L PBTK NA 50% Rat Human +DTXSID6045959 Css NA 22.23 mg/L PBTK NA 95% Rat Human +DTXSID6046000 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046000 Fup 0.0933 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046000 Vd NA 2.65 L/kg 1compartment NA NA Human Human DTXSID6046000 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046000 TK.Half.Life NA 2.624 hours 1compartment NA NA Human Human -DTXSID6046000 Css NA 0.02611 mg/L 3compartmentss NA 50% Human Human -DTXSID6046000 Css NA 0.2442 mg/L 3compartmentss NA 95% Human Human -DTXSID6046000 Css NA 0.02714 mg/L PBTK NA 50% Human Human -DTXSID6046000 Css NA 0.2075 mg/L PBTK NA 95% Human Human -DTXSID6046000 Clint NA 10.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046000 Fup NA 0.0669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046000 Vd NA 3.268 L/kg 1compartment NA NA Rat Human +DTXSID6046000 TK.Half.Life NA 2.496 hours 1compartment NA NA Human Human +DTXSID6046000 Css NA 0.0434 mg/L 3compartmentss NA 50% Human Human +DTXSID6046000 Css NA 0.4926 mg/L 3compartmentss NA 95% Human Human +DTXSID6046000 Css NA 0.04305 mg/L PBTK NA 50% Human Human +DTXSID6046000 Css NA 0.3854 mg/L PBTK NA 95% Human Human +DTXSID6046000 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046000 Fup 0.0933 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046000 Vd NA 2.584 L/kg 1compartment NA NA Rat Human DTXSID6046000 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046000 TK.Half.Life NA 1.124 hours 1compartment NA NA Rat Human -DTXSID6046000 Css NA 0.01436 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046000 Css NA 0.1044 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046000 Css NA 0.01461 mg/L PBTK NA 50% Rat Human -DTXSID6046000 Css NA 0.08656 mg/L PBTK NA 95% Rat Human +DTXSID6046000 TK.Half.Life NA 1.318 hours 1compartment NA NA Rat Human +DTXSID6046000 Css NA 0.005706 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046000 Css NA 0.04982 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046000 Css NA 0.005696 mg/L PBTK NA 50% Rat Human +DTXSID6046000 Css NA 0.03875 mg/L PBTK NA 95% Rat Human DTXSID6046008 Clint NA 89.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6046008 Fup NA 0.3235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046008 Vd NA 5.22 L/kg 1compartment NA NA Human Human +DTXSID6046008 Vd NA 2.992 L/kg 1compartment NA NA Human Human DTXSID6046008 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046008 TK.Half.Life NA 1.929 hours 1compartment NA NA Human Human -DTXSID6046008 Css NA 0.00385 mg/L 3compartmentss NA 50% Human Human -DTXSID6046008 Css NA 0.04044 mg/L 3compartmentss NA 95% Human Human -DTXSID6046008 Css NA 0.006663 mg/L PBTK NA 50% Human Human -DTXSID6046008 Css NA 0.049 mg/L PBTK NA 95% Human Human +DTXSID6046008 TK.Half.Life NA 4.837 hours 1compartment NA NA Human Human +DTXSID6046008 Css NA 0.08122 mg/L 3compartmentss NA 50% Human Human +DTXSID6046008 Css NA 0.5583 mg/L 3compartmentss NA 95% Human Human +DTXSID6046008 Css NA 0.05868 mg/L PBTK NA 50% Human Human +DTXSID6046008 Css NA 0.384 mg/L PBTK NA 95% Human Human DTXSID6046008 Clint NA 89.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6046008 Fup NA 0.3235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046008 Vd NA 5.225 L/kg 1compartment NA NA Rat Human +DTXSID6046008 Vd NA 2.264 L/kg 1compartment NA NA Rat Human DTXSID6046008 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046008 TK.Half.Life NA 0.9329 hours 1compartment NA NA Rat Human -DTXSID6046008 Css NA 0.001988 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046008 Css NA 0.01779 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046008 Css NA 0.003552 mg/L PBTK NA 50% Rat Human -DTXSID6046008 Css NA 0.02111 mg/L PBTK NA 95% Rat Human +DTXSID6046008 TK.Half.Life NA 1.17 hours 1compartment NA NA Rat Human +DTXSID6046008 Css NA 0.002984 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046008 Css NA 0.02317 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046008 Css NA 0.002103 mg/L PBTK NA 50% Rat Human +DTXSID6046008 Css NA 0.01575 mg/L PBTK NA 95% Rat Human DTXSID6046054 Clint NA 2844 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6046054 Fup NA 0.0092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046054 Vd NA 33.04 L/kg 1compartment NA NA Human Human +DTXSID6046054 Vd NA 3.086 L/kg 1compartment NA NA Human Human DTXSID6046054 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046054 TK.Half.Life NA 12.45 hours 1compartment NA NA Human Human -DTXSID6046054 Css NA 0.005392 mg/L 3compartmentss NA 50% Human Human -DTXSID6046054 Css NA 0.03156 mg/L 3compartmentss NA 95% Human Human -DTXSID6046054 Css NA 0.01887 mg/L PBTK NA 50% Human Human -DTXSID6046054 Css NA 0.1014 mg/L PBTK NA 95% Human Human +DTXSID6046054 TK.Half.Life NA 3.196 hours 1compartment NA NA Human Human +DTXSID6046054 Css NA 0.02408 mg/L 3compartmentss NA 50% Human Human +DTXSID6046054 Css NA 0.1691 mg/L 3compartmentss NA 95% Human Human +DTXSID6046054 Css NA 0.01668 mg/L PBTK NA 50% Human Human +DTXSID6046054 Css NA 0.1135 mg/L PBTK NA 95% Human Human DTXSID6046054 Clint NA 2844 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6046054 Fup NA 0.0092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046054 Vd NA 27.39 L/kg 1compartment NA NA Rat Human +DTXSID6046054 Vd NA 2.31 L/kg 1compartment NA NA Rat Human DTXSID6046054 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046054 TK.Half.Life NA 2.899 hours 1compartment NA NA Rat Human -DTXSID6046054 Css NA 0.002767 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046054 Css NA 0.01198 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046054 Css NA 0.01017 mg/L PBTK NA 50% Rat Human -DTXSID6046054 Css NA 0.04612 mg/L PBTK NA 95% Rat Human -DTXSID6046131 Clint NA 2.566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046131 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046131 Vd NA 0.1934 L/kg 1compartment NA NA Human Human -DTXSID6046131 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID6046131 TK.Half.Life NA 43.87 hours 1compartment NA NA Human Human -DTXSID6046131 Css NA 41.49 mg/L 3compartmentss NA 50% Human Human -DTXSID6046131 Css NA 321.8 mg/L 3compartmentss NA 95% Human Human -DTXSID6046131 Css NA 24.35 mg/L PBTK NA 50% Human Human -DTXSID6046131 Css NA 186.4 mg/L PBTK NA 95% Human Human -DTXSID6046131 Clint NA 2.566 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046131 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046131 Vd NA 0.1873 L/kg 1compartment NA NA Rat Human -DTXSID6046131 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6046131 TK.Half.Life NA 24.83 hours 1compartment NA NA Rat Human -DTXSID6046131 Css NA 20.51 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046131 Css NA 124 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046131 Css NA 11.18 mg/L PBTK NA 50% Rat Human -DTXSID6046131 Css NA 67.13 mg/L PBTK NA 95% Rat Human -DTXSID6046133 Clint NA 0.1833 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046133 Fup NA 0.0442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046133 Vd NA 0.2504 L/kg 1compartment NA NA Human Human -DTXSID6046133 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6046133 TK.Half.Life NA 28.13 hours 1compartment NA NA Human Human -DTXSID6046133 Css NA 18.19 mg/L 3compartmentss NA 50% Human Human -DTXSID6046133 Css NA 97.4 mg/L 3compartmentss NA 95% Human Human -DTXSID6046133 Css NA 11.03 mg/L PBTK NA 50% Human Human -DTXSID6046133 Css NA 57.16 mg/L PBTK NA 95% Human Human -DTXSID6046133 Clint NA 0.1833 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046133 Fup NA 0.0442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046133 Vd NA 0.2443 L/kg 1compartment NA NA Rat Human -DTXSID6046133 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6046133 TK.Half.Life NA 10.62 hours 1compartment NA NA Rat Human -DTXSID6046133 Css NA 6.064 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046133 Css NA 28.69 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046133 Css NA 3.418 mg/L PBTK NA 50% Rat Human -DTXSID6046133 Css NA 15.64 mg/L PBTK NA 95% Rat Human -DTXSID6046135 Clint NA 7.871 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046135 Fup NA 0.4449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046135 Vd NA 0.9427 L/kg 1compartment NA NA Human Human +DTXSID6046054 TK.Half.Life NA 0.9224 hours 1compartment NA NA Rat Human +DTXSID6046054 Css NA 0.003232 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046054 Css NA 0.01821 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046054 Css NA 0.002218 mg/L PBTK NA 50% Rat Human +DTXSID6046054 Css NA 0.01244 mg/L PBTK NA 95% Rat Human +DTXSID6046131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046131 Fup 0.0274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046131 Vd NA 0.2681 L/kg 1compartment NA NA Human Human +DTXSID6046131 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046131 TK.Half.Life NA 1.946 hours 1compartment NA NA Human Human +DTXSID6046131 Css NA 1.166 mg/L 3compartmentss NA 50% Human Human +DTXSID6046131 Css NA 11.58 mg/L 3compartmentss NA 95% Human Human +DTXSID6046131 Css NA 0.7047 mg/L PBTK NA 50% Human Human +DTXSID6046131 Css NA 6.724 mg/L PBTK NA 95% Human Human +DTXSID6046131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046131 Fup 0.0274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046131 Vd NA 0.2593 L/kg 1compartment NA NA Rat Human +DTXSID6046131 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6046131 TK.Half.Life NA 1.223 hours 1compartment NA NA Rat Human +DTXSID6046131 Css NA 0.154 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046131 Css NA 1.198 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046131 Css NA 0.08983 mg/L PBTK NA 50% Rat Human +DTXSID6046131 Css NA 0.6794 mg/L PBTK NA 95% Rat Human +DTXSID6046133 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046133 Fup 0.075 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046133 Vd NA 0.3014 L/kg 1compartment NA NA Human Human +DTXSID6046133 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046133 TK.Half.Life NA 2.519 hours 1compartment NA NA Human Human +DTXSID6046133 Css NA 1.268 mg/L 3compartmentss NA 50% Human Human +DTXSID6046133 Css NA 8.694 mg/L 3compartmentss NA 95% Human Human +DTXSID6046133 Css NA 0.7926 mg/L PBTK NA 50% Human Human +DTXSID6046133 Css NA 5.073 mg/L PBTK NA 95% Human Human +DTXSID6046133 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046133 Fup 0.075 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046133 Vd NA 0.2944 L/kg 1compartment NA NA Rat Human +DTXSID6046133 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6046133 TK.Half.Life NA 1.517 hours 1compartment NA NA Rat Human +DTXSID6046133 Css NA 0.1574 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046133 Css NA 0.7758 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046133 Css NA 0.09454 mg/L PBTK NA 50% Rat Human +DTXSID6046133 Css NA 0.4465 mg/L PBTK NA 95% Rat Human +DTXSID6046135 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046135 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046135 Vd NA 0.8724 L/kg 1compartment NA NA Human Human DTXSID6046135 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046135 TK.Half.Life NA 1.558 hours 1compartment NA NA Human Human -DTXSID6046135 Css NA 0.1207 mg/L 3compartmentss NA 50% Human Human -DTXSID6046135 Css NA 0.8764 mg/L 3compartmentss NA 95% Human Human -DTXSID6046135 Css NA 0.09466 mg/L PBTK NA 50% Human Human -DTXSID6046135 Css NA 0.6087 mg/L PBTK NA 95% Human Human -DTXSID6046135 Clint NA 7.871 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046135 Fup NA 0.4449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046135 Vd NA 0.8577 L/kg 1compartment NA NA Rat Human +DTXSID6046135 TK.Half.Life NA 0.984 hours 1compartment NA NA Human Human +DTXSID6046135 Css NA 0.05006 mg/L 3compartmentss NA 50% Human Human +DTXSID6046135 Css NA 0.3962 mg/L 3compartmentss NA 95% Human Human +DTXSID6046135 Css NA 0.03789 mg/L PBTK NA 50% Human Human +DTXSID6046135 Css NA 0.27 mg/L PBTK NA 95% Human Human +DTXSID6046135 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046135 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046135 Vd NA 0.7929 L/kg 1compartment NA NA Rat Human DTXSID6046135 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046135 TK.Half.Life NA 0.7652 hours 1compartment NA NA Rat Human -DTXSID6046135 Css NA 0.06137 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046135 Css NA 0.3438 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046135 Css NA 0.04654 mg/L PBTK NA 50% Rat Human -DTXSID6046135 Css NA 0.2189 mg/L PBTK NA 95% Rat Human -DTXSID6046137 Clint NA 142.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046137 Fup NA 0.0446 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046137 Vd NA 1.313 L/kg 1compartment NA NA Human Human +DTXSID6046135 TK.Half.Life NA 0.4584 hours 1compartment NA NA Rat Human +DTXSID6046135 Css NA 0.006193 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046135 Css NA 0.03853 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046135 Css NA 0.004733 mg/L PBTK NA 50% Rat Human +DTXSID6046135 Css NA 0.02585 mg/L PBTK NA 95% Rat Human +DTXSID6046137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046137 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046137 Vd NA 2.085 L/kg 1compartment NA NA Human Human DTXSID6046137 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046137 TK.Half.Life NA 1.995 hours 1compartment NA NA Human Human -DTXSID6046137 Css NA 0.1099 mg/L 3compartmentss NA 50% Human Human -DTXSID6046137 Css NA 0.889 mg/L 3compartmentss NA 95% Human Human -DTXSID6046137 Css NA 0.06954 mg/L PBTK NA 50% Human Human -DTXSID6046137 Css NA 0.544 mg/L PBTK NA 95% Human Human -DTXSID6046137 Clint NA 142.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046137 Fup NA 0.0446 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046137 Vd NA 0.9885 L/kg 1compartment NA NA Rat Human +DTXSID6046137 TK.Half.Life NA 6.736 hours 1compartment NA NA Human Human +DTXSID6046137 Css NA 0.3444 mg/L 3compartmentss NA 50% Human Human +DTXSID6046137 Css NA 2.432 mg/L 3compartmentss NA 95% Human Human +DTXSID6046137 Css NA 0.235 mg/L PBTK NA 50% Human Human +DTXSID6046137 Css NA 1.579 mg/L PBTK NA 95% Human Human +DTXSID6046137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046137 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046137 Vd NA 1.58 L/kg 1compartment NA NA Rat Human DTXSID6046137 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046137 TK.Half.Life NA 0.7412 hours 1compartment NA NA Rat Human -DTXSID6046137 Css NA 0.06323 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046137 Css NA 0.4354 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046137 Css NA 0.03741 mg/L PBTK NA 50% Rat Human -DTXSID6046137 Css NA 0.2489 mg/L PBTK NA 95% Rat Human -DTXSID6046139 Clint NA 141.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046139 Fup NA 0.4368 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046139 Vd NA 2.977 L/kg 1compartment NA NA Human Human +DTXSID6046137 TK.Half.Life NA 2.172 hours 1compartment NA NA Rat Human +DTXSID6046137 Css NA 0.04441 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046137 Css NA 0.2467 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046137 Css NA 0.02976 mg/L PBTK NA 50% Rat Human +DTXSID6046137 Css NA 0.1593 mg/L PBTK NA 95% Rat Human +DTXSID6046139 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046139 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046139 Vd NA 2.785 L/kg 1compartment NA NA Human Human DTXSID6046139 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046139 TK.Half.Life NA 1.648 hours 1compartment NA NA Human Human -DTXSID6046139 Css NA 0.00552 mg/L 3compartmentss NA 50% Human Human -DTXSID6046139 Css NA 0.05384 mg/L 3compartmentss NA 95% Human Human -DTXSID6046139 Css NA 0.005867 mg/L PBTK NA 50% Human Human -DTXSID6046139 Css NA 0.04512 mg/L PBTK NA 95% Human Human -DTXSID6046139 Clint NA 141.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046139 Fup NA 0.4368 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046139 Vd NA 2.929 L/kg 1compartment NA NA Rat Human +DTXSID6046139 TK.Half.Life NA 2.413 hours 1compartment NA NA Human Human +DTXSID6046139 Css NA 0.03152 mg/L 3compartmentss NA 50% Human Human +DTXSID6046139 Css NA 0.3031 mg/L 3compartmentss NA 95% Human Human +DTXSID6046139 Css NA 0.0333 mg/L PBTK NA 50% Human Human +DTXSID6046139 Css NA 0.2555 mg/L PBTK NA 95% Human Human +DTXSID6046139 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046139 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046139 Vd NA 2.762 L/kg 1compartment NA NA Rat Human DTXSID6046139 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046139 TK.Half.Life NA 0.7377 hours 1compartment NA NA Rat Human -DTXSID6046139 Css NA 0.002958 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046139 Css NA 0.02257 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046139 Css NA 0.003114 mg/L PBTK NA 50% Rat Human -DTXSID6046139 Css NA 0.01892 mg/L PBTK NA 95% Rat Human -DTXSID6046181 Clint NA 44.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046181 Fup NA 0.1128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046181 Vd NA 2.589 L/kg 1compartment NA NA Human Human +DTXSID6046139 TK.Half.Life NA 1.241 hours 1compartment NA NA Rat Human +DTXSID6046139 Css NA 0.003808 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046139 Css NA 0.02835 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046139 Css NA 0.004166 mg/L PBTK NA 50% Rat Human +DTXSID6046139 Css NA 0.02367 mg/L PBTK NA 95% Rat Human +DTXSID6046181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046181 Fup 0.089 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046181 Vd NA 2.405 L/kg 1compartment NA NA Human Human DTXSID6046181 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046181 TK.Half.Life NA 5.259 hours 1compartment NA NA Human Human -DTXSID6046181 Css NA 0.1734 mg/L 3compartmentss NA 50% Human Human -DTXSID6046181 Css NA 1.289 mg/L 3compartmentss NA 95% Human Human -DTXSID6046181 Css NA 0.1267 mg/L PBTK NA 50% Human Human -DTXSID6046181 Css NA 0.8749 mg/L PBTK NA 95% Human Human -DTXSID6046181 Clint NA 44.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046181 Fup NA 0.1128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046181 Vd NA 2.077 L/kg 1compartment NA NA Rat Human +DTXSID6046181 TK.Half.Life NA 8.839 hours 1compartment NA NA Human Human +DTXSID6046181 Css NA 0.398 mg/L 3compartmentss NA 50% Human Human +DTXSID6046181 Css NA 2.805 mg/L 3compartmentss NA 95% Human Human +DTXSID6046181 Css NA 0.2838 mg/L PBTK NA 50% Human Human +DTXSID6046181 Css NA 1.87 mg/L PBTK NA 95% Human Human +DTXSID6046181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046181 Fup 0.089 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046181 Vd NA 1.925 L/kg 1compartment NA NA Rat Human DTXSID6046181 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046181 TK.Half.Life NA 1.726 hours 1compartment NA NA Rat Human -DTXSID6046181 Css NA 0.09668 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046181 Css NA 0.5542 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046181 Css NA 0.06773 mg/L PBTK NA 50% Rat Human -DTXSID6046181 Css NA 0.3665 mg/L PBTK NA 95% Rat Human -DTXSID6046183 Clint NA 18.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046183 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046183 Vd NA 2.687 L/kg 1compartment NA NA Human Human -DTXSID6046183 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6046183 TK.Half.Life NA 31.55 hours 1compartment NA NA Human Human -DTXSID6046183 Css NA 1.575 mg/L 3compartmentss NA 50% Human Human -DTXSID6046183 Css NA 10.19 mg/L 3compartmentss NA 95% Human Human -DTXSID6046183 Css NA 1.068 mg/L PBTK NA 50% Human Human -DTXSID6046183 Css NA 6.63 mg/L PBTK NA 95% Human Human -DTXSID6046183 Clint NA 18.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046183 Fup NA 0.0359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046183 Vd NA 2.01 L/kg 1compartment NA NA Rat Human -DTXSID6046183 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6046183 TK.Half.Life NA 6.876 hours 1compartment NA NA Rat Human -DTXSID6046183 Css NA 0.8733 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046183 Css NA 4.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046183 Css NA 0.5597 mg/L PBTK NA 50% Rat Human -DTXSID6046183 Css NA 2.768 mg/L PBTK NA 95% Rat Human -DTXSID6046185 Clint NA 2.583 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046185 Fup NA 0.0392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046185 Vd NA 0.2284 L/kg 1compartment NA NA Human Human +DTXSID6046181 TK.Half.Life NA 3.003 hours 1compartment NA NA Rat Human +DTXSID6046181 Css NA 0.0513 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046181 Css NA 0.289 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046181 Css NA 0.03617 mg/L PBTK NA 50% Rat Human +DTXSID6046181 Css NA 0.1905 mg/L PBTK NA 95% Rat Human +DTXSID6046183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046183 Fup 0.0465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046183 Vd NA 2.108 L/kg 1compartment NA NA Human Human +DTXSID6046183 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046183 TK.Half.Life NA 12.58 hours 1compartment NA NA Human Human +DTXSID6046183 Css NA 0.7844 mg/L 3compartmentss NA 50% Human Human +DTXSID6046183 Css NA 5.46 mg/L 3compartmentss NA 95% Human Human +DTXSID6046183 Css NA 0.5156 mg/L PBTK NA 50% Human Human +DTXSID6046183 Css NA 3.518 mg/L PBTK NA 95% Human Human +DTXSID6046183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046183 Fup 0.0465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046183 Vd NA 1.578 L/kg 1compartment NA NA Rat Human +DTXSID6046183 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6046183 TK.Half.Life NA 3.916 hours 1compartment NA NA Rat Human +DTXSID6046183 Css NA 0.09967 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046183 Css NA 0.5834 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046183 Css NA 0.06452 mg/L PBTK NA 50% Rat Human +DTXSID6046183 Css NA 0.3621 mg/L PBTK NA 95% Rat Human +DTXSID6046185 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046185 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046185 Vd NA 0.349 L/kg 1compartment NA NA Human Human DTXSID6046185 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046185 TK.Half.Life NA 7.282 hours 1compartment NA NA Human Human -DTXSID6046185 Css NA 5.817 mg/L 3compartmentss NA 50% Human Human -DTXSID6046185 Css NA 41.12 mg/L 3compartmentss NA 95% Human Human -DTXSID6046185 Css NA 3.457 mg/L PBTK NA 50% Human Human -DTXSID6046185 Css NA 24.09 mg/L PBTK NA 95% Human Human -DTXSID6046185 Clint NA 2.583 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046185 Fup NA 0.0392 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046185 Vd NA 0.2248 L/kg 1compartment NA NA Rat Human +DTXSID6046185 TK.Half.Life NA 1.954 hours 1compartment NA NA Human Human +DTXSID6046185 Css NA 0.7648 mg/L 3compartmentss NA 50% Human Human +DTXSID6046185 Css NA 5.108 mg/L 3compartmentss NA 95% Human Human +DTXSID6046185 Css NA 0.4876 mg/L PBTK NA 50% Human Human +DTXSID6046185 Css NA 3.1 mg/L PBTK NA 95% Human Human +DTXSID6046185 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046185 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046185 Vd NA 0.3441 L/kg 1compartment NA NA Rat Human DTXSID6046185 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046185 TK.Half.Life NA 4.153 hours 1compartment NA NA Rat Human -DTXSID6046185 Css NA 2.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046185 Css NA 15.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046185 Css NA 1.563 mg/L PBTK NA 50% Rat Human -DTXSID6046185 Css NA 8.599 mg/L PBTK NA 95% Rat Human -DTXSID6046187 Clint NA 9.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046187 Fup NA 0.1606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046187 Vd NA 2.781 L/kg 1compartment NA NA Human Human -DTXSID6046187 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6046187 TK.Half.Life NA 17.33 hours 1compartment NA NA Human Human -DTXSID6046187 Css NA 0.6745 mg/L 3compartmentss NA 50% Human Human -DTXSID6046187 Css NA 4.126 mg/L 3compartmentss NA 95% Human Human -DTXSID6046187 Css NA 0.5022 mg/L PBTK NA 50% Human Human -DTXSID6046187 Css NA 2.914 mg/L PBTK NA 95% Human Human -DTXSID6046187 Clint NA 9.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046187 Fup NA 0.1606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046187 Vd NA 2.194 L/kg 1compartment NA NA Rat Human +DTXSID6046185 TK.Half.Life NA 1.168 hours 1compartment NA NA Rat Human +DTXSID6046185 Css NA 0.09178 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046185 Css NA 0.4914 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046185 Css NA 0.05717 mg/L PBTK NA 50% Rat Human +DTXSID6046185 Css NA 0.2883 mg/L PBTK NA 95% Rat Human +DTXSID6046187 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046187 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046187 Vd NA 2.945 L/kg 1compartment NA NA Human Human +DTXSID6046187 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046187 TK.Half.Life NA 13.48 hours 1compartment NA NA Human Human +DTXSID6046187 Css NA 0.4718 mg/L 3compartmentss NA 50% Human Human +DTXSID6046187 Css NA 2.939 mg/L 3compartmentss NA 95% Human Human +DTXSID6046187 Css NA 0.3402 mg/L PBTK NA 50% Human Human +DTXSID6046187 Css NA 2.009 mg/L PBTK NA 95% Human Human +DTXSID6046187 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046187 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046187 Vd NA 2.281 L/kg 1compartment NA NA Rat Human DTXSID6046187 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046187 TK.Half.Life NA 4.551 hours 1compartment NA NA Rat Human -DTXSID6046187 Css NA 0.3648 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046187 Css NA 1.584 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046187 Css NA 0.2618 mg/L PBTK NA 50% Rat Human -DTXSID6046187 Css NA 1.07 mg/L PBTK NA 95% Rat Human -DTXSID6046189 Clint NA 0.6497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046189 Fup NA 0.4673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046189 Vd NA 1.239 L/kg 1compartment NA NA Human Human +DTXSID6046187 TK.Half.Life NA 3.074 hours 1compartment NA NA Rat Human +DTXSID6046187 Css NA 0.06052 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046187 Css NA 0.311 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046187 Css NA 0.0436 mg/L PBTK NA 50% Rat Human +DTXSID6046187 Css NA 0.2236 mg/L PBTK NA 95% Rat Human +DTXSID6046189 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046189 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046189 Vd NA 0.8362 L/kg 1compartment NA NA Human Human DTXSID6046189 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046189 TK.Half.Life NA 9.338 hours 1compartment NA NA Human Human -DTXSID6046189 Css NA 0.7548 mg/L 3compartmentss NA 50% Human Human -DTXSID6046189 Css NA 3.889 mg/L 3compartmentss NA 95% Human Human -DTXSID6046189 Css NA 0.6155 mg/L PBTK NA 50% Human Human -DTXSID6046189 Css NA 2.593 mg/L PBTK NA 95% Human Human -DTXSID6046189 Clint NA 0.6497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046189 Fup NA 0.4673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046189 Vd NA 1.074 L/kg 1compartment NA NA Rat Human +DTXSID6046189 TK.Half.Life NA 2.021 hours 1compartment NA NA Human Human +DTXSID6046189 Css NA 0.2046 mg/L 3compartmentss NA 50% Human Human +DTXSID6046189 Css NA 1.283 mg/L 3compartmentss NA 95% Human Human +DTXSID6046189 Css NA 0.1507 mg/L PBTK NA 50% Human Human +DTXSID6046189 Css NA 0.8593 mg/L PBTK NA 95% Human Human +DTXSID6046189 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046189 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046189 Vd NA 0.7475 L/kg 1compartment NA NA Rat Human DTXSID6046189 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046189 TK.Half.Life NA 3.42 hours 1compartment NA NA Rat Human -DTXSID6046189 Css NA 0.2792 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046189 Css NA 1.265 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046189 Css NA 0.2209 mg/L PBTK NA 50% Rat Human -DTXSID6046189 Css NA 0.7807 mg/L PBTK NA 95% Rat Human -DTXSID6046210 Clint NA 22.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046210 Fup NA 0.0968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046210 Vd NA 1.937 L/kg 1compartment NA NA Human Human +DTXSID6046189 TK.Half.Life NA 1.006 hours 1compartment NA NA Rat Human +DTXSID6046189 Css NA 0.02399 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046189 Css NA 0.1156 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046189 Css NA 0.01763 mg/L PBTK NA 50% Rat Human +DTXSID6046189 Css NA 0.07468 mg/L PBTK NA 95% Rat Human +DTXSID6046210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046210 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046210 Vd NA 2.288 L/kg 1compartment NA NA Human Human DTXSID6046210 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046210 TK.Half.Life NA 4.937 hours 1compartment NA NA Human Human -DTXSID6046210 Css NA 0.264 mg/L 3compartmentss NA 50% Human Human -DTXSID6046210 Css NA 2.049 mg/L 3compartmentss NA 95% Human Human -DTXSID6046210 Css NA 0.1895 mg/L PBTK NA 50% Human Human -DTXSID6046210 Css NA 1.355 mg/L PBTK NA 95% Human Human -DTXSID6046210 Clint NA 22.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046210 Fup NA 0.0968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046210 Vd NA 1.658 L/kg 1compartment NA NA Rat Human +DTXSID6046210 TK.Half.Life NA 5.034 hours 1compartment NA NA Human Human +DTXSID6046210 Css NA 0.1925 mg/L 3compartmentss NA 50% Human Human +DTXSID6046210 Css NA 1.571 mg/L 3compartmentss NA 95% Human Human +DTXSID6046210 Css NA 0.1466 mg/L PBTK NA 50% Human Human +DTXSID6046210 Css NA 1.09 mg/L PBTK NA 95% Human Human +DTXSID6046210 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046210 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046210 Vd NA 1.965 L/kg 1compartment NA NA Rat Human DTXSID6046210 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046210 TK.Half.Life NA 2.196 hours 1compartment NA NA Rat Human -DTXSID6046210 Css NA 0.1464 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046210 Css NA 0.8857 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046210 Css NA 0.1003 mg/L PBTK NA 50% Rat Human -DTXSID6046210 Css NA 0.5522 mg/L PBTK NA 95% Rat Human -DTXSID6046212 Clint NA 197.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046212 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046212 Vd NA 66.59 L/kg 1compartment NA NA Human Human -DTXSID6046212 Days.Css NA 41 Days PBTK NA NA Human Human -DTXSID6046212 TK.Half.Life NA 221 hours 1compartment NA NA Human Human -DTXSID6046212 Css NA 0.03525 mg/L 3compartmentss NA 50% Human Human -DTXSID6046212 Css NA 0.2209 mg/L 3compartmentss NA 95% Human Human -DTXSID6046212 Css NA 0.2692 mg/L PBTK NA 50% Human Human -DTXSID6046212 Css NA 1.535 mg/L PBTK NA 95% Human Human -DTXSID6046212 Clint NA 197.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046212 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046212 Vd NA 56.74 L/kg 1compartment NA NA Rat Human -DTXSID6046212 Days.Css NA 28 Days PBTK NA NA Rat Human -DTXSID6046212 TK.Half.Life NA 33.81 hours 1compartment NA NA Rat Human -DTXSID6046212 Css NA 0.01817 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046212 Css NA 0.07754 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046212 Css NA 0.1455 mg/L PBTK NA 50% Rat Human -DTXSID6046212 Css NA 0.6333 mg/L PBTK NA 95% Rat Human -DTXSID6046214 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6046210 TK.Half.Life NA 2.113 hours 1compartment NA NA Rat Human +DTXSID6046210 Css NA 0.02449 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046210 Css NA 0.1493 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046210 Css NA 0.01847 mg/L PBTK NA 50% Rat Human +DTXSID6046210 Css NA 0.1001 mg/L PBTK NA 95% Rat Human +DTXSID6046212 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046212 Fup 0.0279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046212 Vd NA 3.07 L/kg 1compartment NA NA Human Human +DTXSID6046212 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID6046212 TK.Half.Life NA 67.43 hours 1compartment NA NA Human Human +DTXSID6046212 Css NA 2.616 mg/L 3compartmentss NA 50% Human Human +DTXSID6046212 Css NA 17.21 mg/L 3compartmentss NA 95% Human Human +DTXSID6046212 Css NA 1.816 mg/L PBTK NA 50% Human Human +DTXSID6046212 Css NA 11.53 mg/L PBTK NA 95% Human Human +DTXSID6046212 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046212 Fup 0.0279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046212 Vd NA 2.299 L/kg 1compartment NA NA Rat Human +DTXSID6046212 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID6046212 TK.Half.Life NA 9.825 hours 1compartment NA NA Rat Human +DTXSID6046212 Css NA 0.3422 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046212 Css NA 2 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046212 Css NA 0.2339 mg/L PBTK NA 50% Rat Human +DTXSID6046212 Css NA 1.318 mg/L PBTK NA 95% Rat Human +DTXSID6046214 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6046214 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6046214 Vd NA 0.5588 L/kg 1compartment NA NA Human Human +DTXSID6046214 Vd NA 0.5551 L/kg 1compartment NA NA Human Human DTXSID6046214 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046214 TK.Half.Life NA 3.765 hours 1compartment NA NA Human Human -DTXSID6046214 Css NA 0.9478 mg/L 3compartmentss NA 50% Human Human -DTXSID6046214 Css NA 5.263 mg/L 3compartmentss NA 95% Human Human -DTXSID6046214 Css NA 0.7464 mg/L PBTK NA 50% Human Human -DTXSID6046214 Css NA 3.334 mg/L PBTK NA 95% Human Human -DTXSID6046214 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6046214 TK.Half.Life NA 3.739 hours 1compartment NA NA Human Human +DTXSID6046214 Css NA 0.5203 mg/L 3compartmentss NA 50% Human Human +DTXSID6046214 Css NA 2.914 mg/L 3compartmentss NA 95% Human Human +DTXSID6046214 Css NA 0.4076 mg/L PBTK NA 50% Human Human +DTXSID6046214 Css NA 1.874 mg/L PBTK NA 95% Human Human +DTXSID6046214 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6046214 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6046214 Vd NA 0.5938 L/kg 1compartment NA NA Rat Human +DTXSID6046214 Vd NA 0.5907 L/kg 1compartment NA NA Rat Human DTXSID6046214 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046214 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Human -DTXSID6046214 Css NA 0.2428 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046214 Css NA 1.285 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046214 Css NA 0.1837 mg/L PBTK NA 50% Rat Human -DTXSID6046214 Css NA 0.7608 mg/L PBTK NA 95% Rat Human -DTXSID6046216 Clint NA 0.7984 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046216 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046216 Vd NA 0.2006 L/kg 1compartment NA NA Human Human -DTXSID6046216 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID6046216 TK.Half.Life NA 46.99 hours 1compartment NA NA Human Human -DTXSID6046216 Css NA 41.45 mg/L 3compartmentss NA 50% Human Human -DTXSID6046216 Css NA 266.9 mg/L 3compartmentss NA 95% Human Human -DTXSID6046216 Css NA 24.44 mg/L PBTK NA 50% Human Human -DTXSID6046216 Css NA 154.3 mg/L PBTK NA 95% Human Human -DTXSID6046216 Clint NA 0.7984 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046216 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046216 Vd NA 0.1907 L/kg 1compartment NA NA Rat Human -DTXSID6046216 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6046216 TK.Half.Life NA 21.57 hours 1compartment NA NA Rat Human -DTXSID6046216 Css NA 16.59 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046216 Css NA 95.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046216 Css NA 9.074 mg/L PBTK NA 50% Rat Human -DTXSID6046216 Css NA 51.59 mg/L PBTK NA 95% Rat Human -DTXSID6046218 Clint NA 28.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046218 Fup NA 0.0372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046218 Vd NA 2.172 L/kg 1compartment NA NA Human Human +DTXSID6046214 TK.Half.Life NA 1.357 hours 1compartment NA NA Rat Human +DTXSID6046214 Css NA 0.002728 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046214 Css NA 0.01558 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046214 Css NA 0.002052 mg/L PBTK NA 50% Rat Human +DTXSID6046214 Css NA 0.009782 mg/L PBTK NA 95% Rat Human +DTXSID6046216 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046216 Fup 0.0625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046216 Vd NA 0.2904 L/kg 1compartment NA NA Human Human +DTXSID6046216 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046216 TK.Half.Life NA 1.062 hours 1compartment NA NA Human Human +DTXSID6046216 Css NA 0.4742 mg/L 3compartmentss NA 50% Human Human +DTXSID6046216 Css NA 3.76 mg/L 3compartmentss NA 95% Human Human +DTXSID6046216 Css NA 0.2898 mg/L PBTK NA 50% Human Human +DTXSID6046216 Css NA 2.246 mg/L PBTK NA 95% Human Human +DTXSID6046216 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046216 Fup 0.0625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046216 Vd NA 0.275 L/kg 1compartment NA NA Rat Human +DTXSID6046216 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6046216 TK.Half.Life NA 0.6205 hours 1compartment NA NA Rat Human +DTXSID6046216 Css NA 0.06293 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046216 Css NA 0.3748 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046216 Css NA 0.03731 mg/L PBTK NA 50% Rat Human +DTXSID6046216 Css NA 0.2166 mg/L PBTK NA 95% Rat Human +DTXSID6046218 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046218 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046218 Vd NA 1.509 L/kg 1compartment NA NA Human Human DTXSID6046218 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046218 TK.Half.Life NA 9.546 hours 1compartment NA NA Human Human -DTXSID6046218 Css NA 0.5698 mg/L 3compartmentss NA 50% Human Human -DTXSID6046218 Css NA 4.757 mg/L 3compartmentss NA 95% Human Human -DTXSID6046218 Css NA 0.3802 mg/L PBTK NA 50% Human Human -DTXSID6046218 Css NA 2.99 mg/L PBTK NA 95% Human Human -DTXSID6046218 Clint NA 28.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046218 Fup NA 0.0372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046218 Vd NA 1.71 L/kg 1compartment NA NA Rat Human +DTXSID6046218 TK.Half.Life NA 12.25 hours 1compartment NA NA Human Human +DTXSID6046218 Css NA 1.244 mg/L 3compartmentss NA 50% Human Human +DTXSID6046218 Css NA 11.21 mg/L 3compartmentss NA 95% Human Human +DTXSID6046218 Css NA 0.7893 mg/L PBTK NA 50% Human Human +DTXSID6046218 Css NA 6.774 mg/L PBTK NA 95% Human Human +DTXSID6046218 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046218 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046218 Vd NA 1.185 L/kg 1compartment NA NA Rat Human DTXSID6046218 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046218 TK.Half.Life NA 3.386 hours 1compartment NA NA Rat Human -DTXSID6046218 Css NA 0.3231 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046218 Css NA 2.018 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046218 Css NA 0.2063 mg/L PBTK NA 50% Rat Human -DTXSID6046218 Css NA 1.216 mg/L PBTK NA 95% Rat Human -DTXSID6046260 Clint NA 0.03113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046260 Fup NA 0.7083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046260 Vd NA 0.5016 L/kg 1compartment NA NA Human Human +DTXSID6046218 TK.Half.Life NA 5.263 hours 1compartment NA NA Rat Human +DTXSID6046218 Css NA 0.1593 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046218 Css NA 1.248 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046218 Css NA 0.09855 mg/L PBTK NA 50% Rat Human +DTXSID6046218 Css NA 0.7312 mg/L PBTK NA 95% Rat Human +DTXSID6046260 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046260 Fup 0.855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046260 Vd NA 0.6294 L/kg 1compartment NA NA Human Human DTXSID6046260 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046260 TK.Half.Life NA 4.106 hours 1compartment NA NA Human Human -DTXSID6046260 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human -DTXSID6046260 Css NA 6.196 mg/L 3compartmentss NA 95% Human Human -DTXSID6046260 Css NA 0.7738 mg/L PBTK NA 50% Human Human -DTXSID6046260 Css NA 3.855 mg/L PBTK NA 95% Human Human -DTXSID6046260 Clint NA 0.03113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046260 Fup NA 0.7083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046260 Vd NA 0.5357 L/kg 1compartment NA NA Rat Human +DTXSID6046260 TK.Half.Life NA 4.764 hours 1compartment NA NA Human Human +DTXSID6046260 Css NA 0.831 mg/L 3compartmentss NA 50% Human Human +DTXSID6046260 Css NA 5.028 mg/L 3compartmentss NA 95% Human Human +DTXSID6046260 Css NA 0.6706 mg/L PBTK NA 50% Human Human +DTXSID6046260 Css NA 3.212 mg/L PBTK NA 95% Human Human +DTXSID6046260 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046260 Fup 0.855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046260 Vd NA 0.6579 L/kg 1compartment NA NA Rat Human DTXSID6046260 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046260 TK.Half.Life NA 1.579 hours 1compartment NA NA Rat Human -DTXSID6046260 Css NA 0.2817 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046260 Css NA 1.706 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046260 Css NA 0.2065 mg/L PBTK NA 50% Rat Human -DTXSID6046260 Css NA 0.9909 mg/L PBTK NA 95% Rat Human +DTXSID6046260 TK.Half.Life NA 1.696 hours 1compartment NA NA Rat Human +DTXSID6046260 Css NA 0.01542 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046260 Css NA 0.118 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046260 Css NA 0.0119 mg/L PBTK NA 50% Rat Human +DTXSID6046260 Css NA 0.07482 mg/L PBTK NA 95% Rat Human DTXSID6046262 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6046262 Fup NA 0.4953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046262 Vd NA 0.4527 L/kg 1compartment NA NA Human Human +DTXSID6046262 Vd NA 0.4606 L/kg 1compartment NA NA Human Human DTXSID6046262 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046262 TK.Half.Life NA 5.914 hours 1compartment NA NA Human Human -DTXSID6046262 Css NA 1.512 mg/L 3compartmentss NA 50% Human Human -DTXSID6046262 Css NA 7.646 mg/L 3compartmentss NA 95% Human Human -DTXSID6046262 Css NA 1.104 mg/L PBTK NA 50% Human Human -DTXSID6046262 Css NA 4.794 mg/L PBTK NA 95% Human Human +DTXSID6046262 TK.Half.Life NA 6.017 hours 1compartment NA NA Human Human +DTXSID6046262 Css NA 1.262 mg/L 3compartmentss NA 50% Human Human +DTXSID6046262 Css NA 6.472 mg/L 3compartmentss NA 95% Human Human +DTXSID6046262 Css NA 0.931 mg/L PBTK NA 50% Human Human +DTXSID6046262 Css NA 4.072 mg/L PBTK NA 95% Human Human DTXSID6046262 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6046262 Fup NA 0.4953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046262 Vd NA 0.4588 L/kg 1compartment NA NA Rat Human +DTXSID6046262 Vd NA 0.4937 L/kg 1compartment NA NA Rat Human DTXSID6046262 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046262 TK.Half.Life NA 2.042 hours 1compartment NA NA Rat Human -DTXSID6046262 Css NA 0.4129 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046262 Css NA 1.828 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046262 Css NA 0.2878 mg/L PBTK NA 50% Rat Human -DTXSID6046262 Css NA 1.065 mg/L PBTK NA 95% Rat Human -DTXSID6046264 Clint NA 33.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046264 Fup NA 0.2778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046264 Vd NA 1.239 L/kg 1compartment NA NA Human Human +DTXSID6046262 TK.Half.Life NA 2.198 hours 1compartment NA NA Rat Human +DTXSID6046262 Css NA 0.02392 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046262 Css NA 0.168 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046262 Css NA 0.01691 mg/L PBTK NA 50% Rat Human +DTXSID6046262 Css NA 0.105 mg/L PBTK NA 95% Rat Human +DTXSID6046264 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046264 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046264 Vd NA 1.325 L/kg 1compartment NA NA Human Human DTXSID6046264 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046264 TK.Half.Life NA 1.451 hours 1compartment NA NA Human Human -DTXSID6046264 Css NA 0.0547 mg/L 3compartmentss NA 50% Human Human -DTXSID6046264 Css NA 0.395 mg/L 3compartmentss NA 95% Human Human -DTXSID6046264 Css NA 0.0404 mg/L PBTK NA 50% Human Human -DTXSID6046264 Css NA 0.2661 mg/L PBTK NA 95% Human Human -DTXSID6046264 Clint NA 33.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046264 Fup NA 0.2778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046264 Vd NA 1.021 L/kg 1compartment NA NA Rat Human +DTXSID6046264 TK.Half.Life NA 3.735 hours 1compartment NA NA Human Human +DTXSID6046264 Css NA 0.2456 mg/L 3compartmentss NA 50% Human Human +DTXSID6046264 Css NA 1.537 mg/L 3compartmentss NA 95% Human Human +DTXSID6046264 Css NA 0.1844 mg/L PBTK NA 50% Human Human +DTXSID6046264 Css NA 1.049 mg/L PBTK NA 95% Human Human +DTXSID6046264 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046264 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046264 Vd NA 1.087 L/kg 1compartment NA NA Rat Human DTXSID6046264 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046264 TK.Half.Life NA 0.5914 hours 1compartment NA NA Rat Human -DTXSID6046264 Css NA 0.02958 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046264 Css NA 0.1697 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046264 Css NA 0.02118 mg/L PBTK NA 50% Rat Human -DTXSID6046264 Css NA 0.1126 mg/L PBTK NA 95% Rat Human -DTXSID6046266 Clint NA 102.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046266 Fup NA 0.0358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046266 Vd NA 0.6789 L/kg 1compartment NA NA Human Human +DTXSID6046264 TK.Half.Life NA 1.593 hours 1compartment NA NA Rat Human +DTXSID6046264 Css NA 0.0293 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046264 Css NA 0.1359 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046264 Css NA 0.02202 mg/L PBTK NA 50% Rat Human +DTXSID6046264 Css NA 0.09037 mg/L PBTK NA 95% Rat Human +DTXSID6046266 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046266 Fup 0.0589 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046266 Vd NA 1.589 L/kg 1compartment NA NA Human Human DTXSID6046266 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046266 TK.Half.Life NA 1.313 hours 1compartment NA NA Human Human -DTXSID6046266 Css NA 0.1837 mg/L 3compartmentss NA 50% Human Human -DTXSID6046266 Css NA 1.422 mg/L 3compartmentss NA 95% Human Human -DTXSID6046266 Css NA 0.1115 mg/L PBTK NA 50% Human Human -DTXSID6046266 Css NA 0.8574 mg/L PBTK NA 95% Human Human -DTXSID6046266 Clint NA 102.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046266 Fup NA 0.0358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046266 Vd NA 0.5212 L/kg 1compartment NA NA Rat Human +DTXSID6046266 TK.Half.Life NA 6.756 hours 1compartment NA NA Human Human +DTXSID6046266 Css NA 0.5336 mg/L 3compartmentss NA 50% Human Human +DTXSID6046266 Css NA 4.248 mg/L 3compartmentss NA 95% Human Human +DTXSID6046266 Css NA 0.3458 mg/L PBTK NA 50% Human Human +DTXSID6046266 Css NA 2.597 mg/L PBTK NA 95% Human Human +DTXSID6046266 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046266 Fup 0.0589 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046266 Vd NA 1.197 L/kg 1compartment NA NA Rat Human DTXSID6046266 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046266 TK.Half.Life NA 0.5563 hours 1compartment NA NA Rat Human -DTXSID6046266 Css NA 0.1057 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046266 Css NA 0.6452 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046266 Css NA 0.06014 mg/L PBTK NA 50% Rat Human -DTXSID6046266 Css NA 0.3613 mg/L PBTK NA 95% Rat Human -DTXSID6046268 Clint NA 2.325 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046268 Fup NA 0.4961 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046268 Vd NA 2.669 L/kg 1compartment NA NA Human Human -DTXSID6046268 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046268 TK.Half.Life NA 7.79 hours 1compartment NA NA Human Human -DTXSID6046268 Css NA 0.2126 mg/L 3compartmentss NA 50% Human Human -DTXSID6046268 Css NA 1.628 mg/L 3compartmentss NA 95% Human Human -DTXSID6046268 Css NA 0.238 mg/L PBTK NA 50% Human Human -DTXSID6046268 Css NA 1.232 mg/L PBTK NA 95% Human Human -DTXSID6046268 Clint NA 2.325 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046268 Fup NA 0.4961 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046268 Vd NA 2.689 L/kg 1compartment NA NA Rat Human -DTXSID6046268 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046268 TK.Half.Life NA 4.313 hours 1compartment NA NA Rat Human -DTXSID6046268 Css NA 0.09134 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046268 Css NA 0.6202 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046268 Css NA 0.1017 mg/L PBTK NA 50% Rat Human -DTXSID6046268 Css NA 0.4379 mg/L PBTK NA 95% Rat Human -DTXSID6046341 Clint NA 112.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046341 Fup NA 0.4309 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046341 Vd NA 1.836 L/kg 1compartment NA NA Human Human -DTXSID6046341 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046341 TK.Half.Life NA 1.191 hours 1compartment NA NA Human Human -DTXSID6046341 Css NA 0.007742 mg/L 3compartmentss NA 50% Human Human -DTXSID6046341 Css NA 0.07179 mg/L 3compartmentss NA 95% Human Human -DTXSID6046341 Css NA 0.007166 mg/L PBTK NA 50% Human Human -DTXSID6046341 Css NA 0.05563 mg/L PBTK NA 95% Human Human -DTXSID6046341 Clint NA 112.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046341 Fup NA 0.4309 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046341 Vd NA 1.852 L/kg 1compartment NA NA Rat Human +DTXSID6046266 TK.Half.Life NA 2.541 hours 1compartment NA NA Rat Human +DTXSID6046266 Css NA 0.0706 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046266 Css NA 0.4297 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046266 Css NA 0.04465 mg/L PBTK NA 50% Rat Human +DTXSID6046266 Css NA 0.2589 mg/L PBTK NA 95% Rat Human +DTXSID6046268 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046268 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046268 Vd NA 2.55 L/kg 1compartment NA NA Human Human +DTXSID6046268 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID6046268 TK.Half.Life NA 35.51 hours 1compartment NA NA Human Human +DTXSID6046268 Css NA 0.568 mg/L 3compartmentss NA 50% Human Human +DTXSID6046268 Css NA 3.682 mg/L 3compartmentss NA 95% Human Human +DTXSID6046268 Css NA 0.624 mg/L PBTK NA 50% Human Human +DTXSID6046268 Css NA 2.779 mg/L PBTK NA 95% Human Human +DTXSID6046268 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046268 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046268 Vd NA 2.566 L/kg 1compartment NA NA Rat Human +DTXSID6046268 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6046268 TK.Half.Life NA 12.16 hours 1compartment NA NA Rat Human +DTXSID6046268 Css NA 0.00299 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046268 Css NA 0.01884 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046268 Css NA 0.003266 mg/L PBTK NA 50% Rat Human +DTXSID6046268 Css NA 0.01413 mg/L PBTK NA 95% Rat Human +DTXSID6046341 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046341 Fup 0.54 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046341 Vd NA 2.144 L/kg 1compartment NA NA Human Human +DTXSID6046341 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6046341 TK.Half.Life NA 25.76 hours 1compartment NA NA Human Human +DTXSID6046341 Css NA 0.9085 mg/L 3compartmentss NA 50% Human Human +DTXSID6046341 Css NA 6.482 mg/L 3compartmentss NA 95% Human Human +DTXSID6046341 Css NA 0.9202 mg/L PBTK NA 50% Human Human +DTXSID6046341 Css NA 4.462 mg/L PBTK NA 95% Human Human +DTXSID6046341 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046341 Fup 0.54 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046341 Vd NA 2.169 L/kg 1compartment NA NA Rat Human DTXSID6046341 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046341 TK.Half.Life NA 0.555 hours 1compartment NA NA Rat Human -DTXSID6046341 Css NA 0.004178 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046341 Css NA 0.03236 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046341 Css NA 0.003786 mg/L PBTK NA 50% Rat Human -DTXSID6046341 Css NA 0.02417 mg/L PBTK NA 95% Rat Human -DTXSID6046343 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046343 Fup NA 0.2819 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046343 Vd NA 0.5636 L/kg 1compartment NA NA Human Human +DTXSID6046341 TK.Half.Life NA 8.859 hours 1compartment NA NA Rat Human +DTXSID6046341 Css NA 0.02188 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046341 Css NA 0.2011 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046341 Css NA 0.02271 mg/L PBTK NA 50% Rat Human +DTXSID6046341 Css NA 0.1404 mg/L PBTK NA 95% Rat Human +DTXSID6046343 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046343 Fup 0.756 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046343 Vd NA 0.9035 L/kg 1compartment NA NA Human Human DTXSID6046343 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046343 TK.Half.Life NA 1.125 hours 1compartment NA NA Human Human -DTXSID6046343 Css NA 0.1603 mg/L 3compartmentss NA 50% Human Human -DTXSID6046343 Css NA 1.087 mg/L 3compartmentss NA 95% Human Human -DTXSID6046343 Css NA 0.112 mg/L PBTK NA 50% Human Human -DTXSID6046343 Css NA 0.7113 mg/L PBTK NA 95% Human Human -DTXSID6046343 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046343 Fup NA 0.2819 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046343 Vd NA 0.5408 L/kg 1compartment NA NA Rat Human +DTXSID6046343 TK.Half.Life NA 7.844 hours 1compartment NA NA Human Human +DTXSID6046343 Css NA 0.9608 mg/L 3compartmentss NA 50% Human Human +DTXSID6046343 Css NA 6.297 mg/L 3compartmentss NA 95% Human Human +DTXSID6046343 Css NA 0.8184 mg/L PBTK NA 50% Human Human +DTXSID6046343 Css NA 4.087 mg/L PBTK NA 95% Human Human +DTXSID6046343 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046343 Fup 0.756 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046343 Vd NA 0.8916 L/kg 1compartment NA NA Rat Human DTXSID6046343 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046343 TK.Half.Life NA 0.608 hours 1compartment NA NA Rat Human -DTXSID6046343 Css NA 0.08459 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046343 Css NA 0.4181 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046343 Css NA 0.05679 mg/L PBTK NA 50% Rat Human -DTXSID6046343 Css NA 0.2555 mg/L PBTK NA 95% Rat Human +DTXSID6046343 TK.Half.Life NA 2.609 hours 1compartment NA NA Rat Human +DTXSID6046343 Css NA 0.05736 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046343 Css NA 0.362 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046343 Css NA 0.04923 mg/L PBTK NA 50% Rat Human +DTXSID6046343 Css NA 0.2261 mg/L PBTK NA 95% Rat Human DTXSID6046345 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6046345 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046345 Vd NA 0.6656 L/kg 1compartment NA NA Human Human +DTXSID6046345 Vd NA 0.6071 L/kg 1compartment NA NA Human Human DTXSID6046345 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046345 TK.Half.Life NA 4.308 hours 1compartment NA NA Human Human -DTXSID6046345 Css NA 0.8554 mg/L 3compartmentss NA 50% Human Human -DTXSID6046345 Css NA 5.586 mg/L 3compartmentss NA 95% Human Human -DTXSID6046345 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID6046345 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID6046345 TK.Half.Life NA 3.929 hours 1compartment NA NA Human Human +DTXSID6046345 Css NA 0.7326 mg/L 3compartmentss NA 50% Human Human +DTXSID6046345 Css NA 5.125 mg/L 3compartmentss NA 95% Human Human +DTXSID6046345 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID6046345 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID6046345 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6046345 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046345 Vd NA 0.7214 L/kg 1compartment NA NA Rat Human +DTXSID6046345 Vd NA 0.6594 L/kg 1compartment NA NA Rat Human DTXSID6046345 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046345 TK.Half.Life NA 1.591 hours 1compartment NA NA Rat Human -DTXSID6046345 Css NA 0.2151 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046345 Css NA 1.343 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046345 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID6046345 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID6046347 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046347 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046347 Vd NA 0.7448 L/kg 1compartment NA NA Human Human +DTXSID6046345 TK.Half.Life NA 1.454 hours 1compartment NA NA Rat Human +DTXSID6046345 Css NA 0.01348 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046345 Css NA 0.1018 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046345 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID6046345 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID6046347 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046347 Fup 0.821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046347 Vd NA 0.635 L/kg 1compartment NA NA Human Human DTXSID6046347 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046347 TK.Half.Life NA 4.82 hours 1compartment NA NA Human Human -DTXSID6046347 Css NA 0.8364 mg/L 3compartmentss NA 50% Human Human -DTXSID6046347 Css NA 5.53 mg/L 3compartmentss NA 95% Human Human -DTXSID6046347 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID6046347 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID6046347 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046347 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046347 Vd NA 0.7872 L/kg 1compartment NA NA Rat Human +DTXSID6046347 TK.Half.Life NA 5.005 hours 1compartment NA NA Human Human +DTXSID6046347 Css NA 0.853 mg/L 3compartmentss NA 50% Human Human +DTXSID6046347 Css NA 5.016 mg/L 3compartmentss NA 95% Human Human +DTXSID6046347 Css NA 0.6874 mg/L PBTK NA 50% Human Human +DTXSID6046347 Css NA 3.282 mg/L PBTK NA 95% Human Human +DTXSID6046347 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046347 Fup 0.821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046347 Vd NA 0.6742 L/kg 1compartment NA NA Rat Human DTXSID6046347 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046347 TK.Half.Life NA 1.736 hours 1compartment NA NA Rat Human -DTXSID6046347 Css NA 0.2101 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046347 Css NA 1.333 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046347 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID6046347 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID6046349 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046349 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046349 Vd NA 1.509 L/kg 1compartment NA NA Human Human -DTXSID6046349 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046349 TK.Half.Life NA 9.767 hours 1compartment NA NA Human Human -DTXSID6046349 Css NA 0.7324 mg/L 3compartmentss NA 50% Human Human -DTXSID6046349 Css NA 5.32 mg/L 3compartmentss NA 95% Human Human -DTXSID6046349 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID6046349 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID6046349 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046349 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046349 Vd NA 1.551 L/kg 1compartment NA NA Rat Human +DTXSID6046347 TK.Half.Life NA 1.811 hours 1compartment NA NA Rat Human +DTXSID6046347 Css NA 0.01611 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046347 Css NA 0.1208 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046347 Css NA 0.01235 mg/L PBTK NA 50% Rat Human +DTXSID6046347 Css NA 0.07758 mg/L PBTK NA 95% Rat Human +DTXSID6046349 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046349 Fup 0.777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046349 Vd NA 1.302 L/kg 1compartment NA NA Human Human +DTXSID6046349 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6046349 TK.Half.Life NA 10.84 hours 1compartment NA NA Human Human +DTXSID6046349 Css NA 0.7907 mg/L 3compartmentss NA 50% Human Human +DTXSID6046349 Css NA 5.061 mg/L 3compartmentss NA 95% Human Human +DTXSID6046349 Css NA 0.7176 mg/L PBTK NA 50% Human Human +DTXSID6046349 Css NA 3.354 mg/L PBTK NA 95% Human Human +DTXSID6046349 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046349 Fup 0.777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046349 Vd NA 1.336 L/kg 1compartment NA NA Rat Human DTXSID6046349 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046349 TK.Half.Life NA 3.42 hours 1compartment NA NA Rat Human -DTXSID6046349 Css NA 0.1812 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046349 Css NA 1.251 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046349 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID6046349 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID6046391 Clint NA 0.4347 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046391 Fup NA 0.4878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046391 Vd NA 0.9437 L/kg 1compartment NA NA Human Human +DTXSID6046349 TK.Half.Life NA 3.79 hours 1compartment NA NA Rat Human +DTXSID6046349 Css NA 0.01947 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046349 Css NA 0.1509 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046349 Css NA 0.01724 mg/L PBTK NA 50% Rat Human +DTXSID6046349 Css NA 0.1034 mg/L PBTK NA 95% Rat Human +DTXSID6046391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046391 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046391 Vd NA 0.7487 L/kg 1compartment NA NA Human Human DTXSID6046391 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046391 TK.Half.Life NA 7.707 hours 1compartment NA NA Human Human -DTXSID6046391 Css NA 0.8497 mg/L 3compartmentss NA 50% Human Human -DTXSID6046391 Css NA 4.432 mg/L 3compartmentss NA 95% Human Human -DTXSID6046391 Css NA 0.6776 mg/L PBTK NA 50% Human Human -DTXSID6046391 Css NA 2.882 mg/L PBTK NA 95% Human Human -DTXSID6046391 Clint NA 0.4347 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046391 Fup NA 0.4878 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046391 Vd NA 0.8544 L/kg 1compartment NA NA Rat Human +DTXSID6046391 TK.Half.Life NA 0.941 hours 1compartment NA NA Human Human +DTXSID6046391 Css NA 0.06251 mg/L 3compartmentss NA 50% Human Human +DTXSID6046391 Css NA 0.4675 mg/L 3compartmentss NA 95% Human Human +DTXSID6046391 Css NA 0.0453 mg/L PBTK NA 50% Human Human +DTXSID6046391 Css NA 0.3128 mg/L PBTK NA 95% Human Human +DTXSID6046391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046391 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046391 Vd NA 0.6759 L/kg 1compartment NA NA Rat Human DTXSID6046391 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046391 TK.Half.Life NA 2.899 hours 1compartment NA NA Rat Human -DTXSID6046391 Css NA 0.2925 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046391 Css NA 1.371 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046391 Css NA 0.2244 mg/L PBTK NA 50% Rat Human -DTXSID6046391 Css NA 0.8283 mg/L PBTK NA 95% Rat Human -DTXSID6046393 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046393 Fup NA 0.8052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046393 Vd NA 0.4217 L/kg 1compartment NA NA Human Human +DTXSID6046391 TK.Half.Life NA 0.4429 hours 1compartment NA NA Rat Human +DTXSID6046391 Css NA 0.007817 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046391 Css NA 0.04632 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046391 Css NA 0.005598 mg/L PBTK NA 50% Rat Human +DTXSID6046391 Css NA 0.0304 mg/L PBTK NA 95% Rat Human +DTXSID6046393 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046393 Fup 0.836 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046393 Vd NA 0.6543 L/kg 1compartment NA NA Human Human DTXSID6046393 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046393 TK.Half.Life NA 3.388 hours 1compartment NA NA Human Human -DTXSID6046393 Css NA 1.129 mg/L 3compartmentss NA 50% Human Human -DTXSID6046393 Css NA 6.022 mg/L 3compartmentss NA 95% Human Human -DTXSID6046393 Css NA 0.8162 mg/L PBTK NA 50% Human Human -DTXSID6046393 Css NA 3.683 mg/L PBTK NA 95% Human Human -DTXSID6046393 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046393 Fup NA 0.8052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046393 Vd NA 0.4503 L/kg 1compartment NA NA Rat Human +DTXSID6046393 TK.Half.Life NA 5.063 hours 1compartment NA NA Human Human +DTXSID6046393 Css NA 0.8416 mg/L 3compartmentss NA 50% Human Human +DTXSID6046393 Css NA 5.043 mg/L 3compartmentss NA 95% Human Human +DTXSID6046393 Css NA 0.6769 mg/L PBTK NA 50% Human Human +DTXSID6046393 Css NA 3.255 mg/L PBTK NA 95% Human Human +DTXSID6046393 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046393 Fup 0.836 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046393 Vd NA 0.6946 L/kg 1compartment NA NA Rat Human DTXSID6046393 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046393 TK.Half.Life NA 1.233 hours 1compartment NA NA Rat Human -DTXSID6046393 Css NA 0.2922 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046393 Css NA 1.614 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046393 Css NA 0.2019 mg/L PBTK NA 50% Rat Human -DTXSID6046393 Css NA 0.9249 mg/L PBTK NA 95% Rat Human -DTXSID6046395 Clint NA 5.679 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046395 Fup NA 0.0558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046395 Vd NA 0.2467 L/kg 1compartment NA NA Human Human +DTXSID6046393 TK.Half.Life NA 1.832 hours 1compartment NA NA Rat Human +DTXSID6046393 Css NA 0.01574 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046393 Css NA 0.1146 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046393 Css NA 0.01223 mg/L PBTK NA 50% Rat Human +DTXSID6046393 Css NA 0.07402 mg/L PBTK NA 95% Rat Human +DTXSID6046395 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046395 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046395 Vd NA 0.3439 L/kg 1compartment NA NA Human Human DTXSID6046395 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046395 TK.Half.Life NA 2.932 hours 1compartment NA NA Human Human -DTXSID6046395 Css NA 1.986 mg/L 3compartmentss NA 50% Human Human -DTXSID6046395 Css NA 13.33 mg/L 3compartmentss NA 95% Human Human -DTXSID6046395 Css NA 1.196 mg/L PBTK NA 50% Human Human -DTXSID6046395 Css NA 7.852 mg/L PBTK NA 95% Human Human -DTXSID6046395 Clint NA 5.679 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046395 Fup NA 0.0558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046395 Vd NA 0.239 L/kg 1compartment NA NA Rat Human +DTXSID6046395 TK.Half.Life NA 0.7195 hours 1compartment NA NA Human Human +DTXSID6046395 Css NA 0.1933 mg/L 3compartmentss NA 50% Human Human +DTXSID6046395 Css NA 1.591 mg/L 3compartmentss NA 95% Human Human +DTXSID6046395 Css NA 0.1233 mg/L PBTK NA 50% Human Human +DTXSID6046395 Css NA 0.9522 mg/L PBTK NA 95% Human Human +DTXSID6046395 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046395 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046395 Vd NA 0.3334 L/kg 1compartment NA NA Rat Human DTXSID6046395 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046395 TK.Half.Life NA 1.759 hours 1compartment NA NA Rat Human -DTXSID6046395 Css NA 1.046 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046395 Css NA 5.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046395 Css NA 0.5893 mg/L PBTK NA 50% Rat Human -DTXSID6046395 Css NA 2.977 mg/L PBTK NA 95% Rat Human +DTXSID6046395 TK.Half.Life NA 0.4016 hours 1compartment NA NA Rat Human +DTXSID6046395 Css NA 0.02505 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046395 Css NA 0.1574 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046395 Css NA 0.01551 mg/L PBTK NA 50% Rat Human +DTXSID6046395 Css NA 0.09263 mg/L PBTK NA 95% Rat Human DTXSID6046397 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6046397 Fup NA 0.5369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046397 Vd NA 0.4718 L/kg 1compartment NA NA Human Human +DTXSID6046397 Vd NA 0.4616 L/kg 1compartment NA NA Human Human DTXSID6046397 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046397 TK.Half.Life NA 5.686 hours 1compartment NA NA Human Human -DTXSID6046397 Css NA 1.435 mg/L 3compartmentss NA 50% Human Human -DTXSID6046397 Css NA 7.951 mg/L 3compartmentss NA 95% Human Human -DTXSID6046397 Css NA 1.066 mg/L PBTK NA 50% Human Human -DTXSID6046397 Css NA 4.958 mg/L PBTK NA 95% Human Human +DTXSID6046397 TK.Half.Life NA 5.563 hours 1compartment NA NA Human Human +DTXSID6046397 Css NA 1.223 mg/L 3compartmentss NA 50% Human Human +DTXSID6046397 Css NA 6.937 mg/L 3compartmentss NA 95% Human Human +DTXSID6046397 Css NA 0.9036 mg/L PBTK NA 50% Human Human +DTXSID6046397 Css NA 4.309 mg/L PBTK NA 95% Human Human DTXSID6046397 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6046397 Fup NA 0.5369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046397 Vd NA 0.4787 L/kg 1compartment NA NA Rat Human +DTXSID6046397 Vd NA 0.5007 L/kg 1compartment NA NA Rat Human DTXSID6046397 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046397 TK.Half.Life NA 1.966 hours 1compartment NA NA Rat Human -DTXSID6046397 Css NA 0.384 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046397 Css NA 1.96 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046397 Css NA 0.2715 mg/L PBTK NA 50% Rat Human -DTXSID6046397 Css NA 1.137 mg/L PBTK NA 95% Rat Human -DTXSID6046399 Clint NA 0.3491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046399 Fup NA 0.4424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046399 Vd NA 0.3718 L/kg 1compartment NA NA Human Human +DTXSID6046397 TK.Half.Life NA 2.056 hours 1compartment NA NA Rat Human +DTXSID6046397 Css NA 0.02298 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046397 Css NA 0.1752 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046397 Css NA 0.01624 mg/L PBTK NA 50% Rat Human +DTXSID6046397 Css NA 0.1092 mg/L PBTK NA 95% Rat Human +DTXSID6046399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046399 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046399 Vd NA 0.3544 L/kg 1compartment NA NA Human Human DTXSID6046399 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046399 TK.Half.Life NA 3.481 hours 1compartment NA NA Human Human -DTXSID6046399 Css NA 1.097 mg/L 3compartmentss NA 50% Human Human -DTXSID6046399 Css NA 5.046 mg/L 3compartmentss NA 95% Human Human -DTXSID6046399 Css NA 0.758 mg/L PBTK NA 50% Human Human -DTXSID6046399 Css NA 3.144 mg/L PBTK NA 95% Human Human -DTXSID6046399 Clint NA 0.3491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046399 Fup NA 0.4424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046399 Vd NA 0.3811 L/kg 1compartment NA NA Rat Human +DTXSID6046399 TK.Half.Life NA 0.4273 hours 1compartment NA NA Human Human +DTXSID6046399 Css NA 0.05443 mg/L 3compartmentss NA 50% Human Human +DTXSID6046399 Css NA 0.42 mg/L 3compartmentss NA 95% Human Human +DTXSID6046399 Css NA 0.03682 mg/L PBTK NA 50% Human Human +DTXSID6046399 Css NA 0.2688 mg/L PBTK NA 95% Human Human +DTXSID6046399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046399 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046399 Vd NA 0.3623 L/kg 1compartment NA NA Rat Human DTXSID6046399 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046399 TK.Half.Life NA 1.488 hours 1compartment NA NA Rat Human -DTXSID6046399 Css NA 0.3714 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046399 Css NA 1.536 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046399 Css NA 0.2446 mg/L PBTK NA 50% Rat Human -DTXSID6046399 Css NA 0.8795 mg/L PBTK NA 95% Rat Human -DTXSID6046420 Clint NA 7.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6046399 TK.Half.Life NA 0.2232 hours 1compartment NA NA Rat Human +DTXSID6046399 Css NA 0.006837 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046399 Css NA 0.04047 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046399 Css NA 0.004559 mg/L PBTK NA 50% Rat Human +DTXSID6046399 Css NA 0.02515 mg/L PBTK NA 95% Rat Human +DTXSID6046420 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6046420 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6046420 Vd NA 1.665 L/kg 1compartment NA NA Human Human +DTXSID6046420 Vd NA 0.4757 L/kg 1compartment NA NA Human Human DTXSID6046420 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046420 TK.Half.Life NA 1.613 hours 1compartment NA NA Human Human -DTXSID6046420 Css NA 0.06213 mg/L 3compartmentss NA 50% Human Human -DTXSID6046420 Css NA 0.4075 mg/L 3compartmentss NA 95% Human Human -DTXSID6046420 Css NA 0.05834 mg/L PBTK NA 50% Human Human -DTXSID6046420 Css NA 0.3328 mg/L PBTK NA 95% Human Human -DTXSID6046420 Clint NA 7.305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6046420 TK.Half.Life NA 3.42 hours 1compartment NA NA Human Human +DTXSID6046420 Css NA 0.5446 mg/L 3compartmentss NA 50% Human Human +DTXSID6046420 Css NA 2.132 mg/L 3compartmentss NA 95% Human Human +DTXSID6046420 Css NA 0.4036 mg/L PBTK NA 50% Human Human +DTXSID6046420 Css NA 1.416 mg/L PBTK NA 95% Human Human +DTXSID6046420 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6046420 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6046420 Vd NA 1.709 L/kg 1compartment NA NA Rat Human +DTXSID6046420 Vd NA 0.5012 L/kg 1compartment NA NA Rat Human DTXSID6046420 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046420 TK.Half.Life NA 0.8749 hours 1compartment NA NA Rat Human -DTXSID6046420 Css NA 0.02963 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046420 Css NA 0.1577 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046420 Css NA 0.02805 mg/L PBTK NA 50% Rat Human -DTXSID6046420 Css NA 0.1197 mg/L PBTK NA 95% Rat Human -DTXSID6046422 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046422 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046422 Vd NA 0.7645 L/kg 1compartment NA NA Human Human +DTXSID6046420 TK.Half.Life NA 1.228 hours 1compartment NA NA Rat Human +DTXSID6046420 Css NA 0.002808 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046420 Css NA 0.01137 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046420 Css NA 0.00201 mg/L PBTK NA 50% Rat Human +DTXSID6046420 Css NA 0.007232 mg/L PBTK NA 95% Rat Human +DTXSID6046422 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046422 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046422 Vd NA 0.5782 L/kg 1compartment NA NA Human Human DTXSID6046422 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046422 TK.Half.Life NA 4.948 hours 1compartment NA NA Human Human -DTXSID6046422 Css NA 0.8343 mg/L 3compartmentss NA 50% Human Human -DTXSID6046422 Css NA 5.575 mg/L 3compartmentss NA 95% Human Human -DTXSID6046422 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID6046422 Css NA 3.599 mg/L PBTK NA 95% Human Human -DTXSID6046422 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046422 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046422 Vd NA 0.7995 L/kg 1compartment NA NA Rat Human +DTXSID6046422 TK.Half.Life NA 5.39 hours 1compartment NA NA Human Human +DTXSID6046422 Css NA 0.6222 mg/L 3compartmentss NA 50% Human Human +DTXSID6046422 Css NA 4.024 mg/L 3compartmentss NA 95% Human Human +DTXSID6046422 Css NA 0.4858 mg/L PBTK NA 50% Human Human +DTXSID6046422 Css NA 2.574 mg/L PBTK NA 95% Human Human +DTXSID6046422 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046422 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046422 Vd NA 0.6113 L/kg 1compartment NA NA Rat Human DTXSID6046422 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046422 TK.Half.Life NA 1.763 hours 1compartment NA NA Rat Human -DTXSID6046422 Css NA 0.21 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046422 Css NA 1.333 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046422 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID6046422 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID6046424 Clint NA 16.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046424 Fup NA 0.3542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046424 Vd NA 2.649 L/kg 1compartment NA NA Human Human +DTXSID6046422 TK.Half.Life NA 1.942 hours 1compartment NA NA Rat Human +DTXSID6046422 Css NA 0.003264 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046422 Css NA 0.02302 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046422 Css NA 0.002446 mg/L PBTK NA 50% Rat Human +DTXSID6046422 Css NA 0.01379 mg/L PBTK NA 95% Rat Human +DTXSID6046424 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046424 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046424 Vd NA 2.552 L/kg 1compartment NA NA Human Human DTXSID6046424 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046424 TK.Half.Life NA 5.415 hours 1compartment NA NA Human Human -DTXSID6046424 Css NA 0.1562 mg/L 3compartmentss NA 50% Human Human -DTXSID6046424 Css NA 0.9551 mg/L 3compartmentss NA 95% Human Human -DTXSID6046424 Css NA 0.123 mg/L PBTK NA 50% Human Human -DTXSID6046424 Css NA 0.7109 mg/L PBTK NA 95% Human Human -DTXSID6046424 Clint NA 16.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046424 Fup NA 0.3542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046424 Vd NA 2.102 L/kg 1compartment NA NA Rat Human +DTXSID6046424 TK.Half.Life NA 11.24 hours 1compartment NA NA Human Human +DTXSID6046424 Css NA 0.4166 mg/L 3compartmentss NA 50% Human Human +DTXSID6046424 Css NA 2.333 mg/L 3compartmentss NA 95% Human Human +DTXSID6046424 Css NA 0.3221 mg/L PBTK NA 50% Human Human +DTXSID6046424 Css NA 1.699 mg/L PBTK NA 95% Human Human +DTXSID6046424 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046424 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046424 Vd NA 2.021 L/kg 1compartment NA NA Rat Human DTXSID6046424 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046424 TK.Half.Life NA 1.614 hours 1compartment NA NA Rat Human -DTXSID6046424 Css NA 0.08266 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046424 Css NA 0.3986 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046424 Css NA 0.06352 mg/L PBTK NA 50% Rat Human -DTXSID6046424 Css NA 0.287 mg/L PBTK NA 95% Rat Human -DTXSID6046426 Clint NA 85.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6046424 TK.Half.Life NA 3.233 hours 1compartment NA NA Rat Human +DTXSID6046424 Css NA 0.0496 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046424 Css NA 0.1966 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046424 Css NA 0.03864 mg/L PBTK NA 50% Rat Human +DTXSID6046424 Css NA 0.1379 mg/L PBTK NA 95% Rat Human +DTXSID6046426 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6046426 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6046426 Vd NA 6.004 L/kg 1compartment NA NA Human Human +DTXSID6046426 Vd NA 4.315 L/kg 1compartment NA NA Human Human DTXSID6046426 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046426 TK.Half.Life NA 2.116 hours 1compartment NA NA Human Human -DTXSID6046426 Css NA 0.003608 mg/L 3compartmentss NA 50% Human Human -DTXSID6046426 Css NA 0.03806 mg/L 3compartmentss NA 95% Human Human -DTXSID6046426 Css NA 0.006461 mg/L PBTK NA 50% Human Human -DTXSID6046426 Css NA 0.04794 mg/L PBTK NA 95% Human Human -DTXSID6046426 Clint NA 85.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6046426 TK.Half.Life NA 3.031 hours 1compartment NA NA Human Human +DTXSID6046426 Css NA 0.0069 mg/L 3compartmentss NA 50% Human Human +DTXSID6046426 Css NA 0.1002 mg/L 3compartmentss NA 95% Human Human +DTXSID6046426 Css NA 0.01011 mg/L PBTK NA 50% Human Human +DTXSID6046426 Css NA 0.1063 mg/L PBTK NA 95% Human Human +DTXSID6046426 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6046426 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6046426 Vd NA 6.083 L/kg 1compartment NA NA Rat Human +DTXSID6046426 Vd NA 4.363 L/kg 1compartment NA NA Rat Human DTXSID6046426 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046426 TK.Half.Life NA 1.026 hours 1compartment NA NA Rat Human -DTXSID6046426 Css NA 0.001823 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046426 Css NA 0.01727 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046426 Css NA 0.003445 mg/L PBTK NA 50% Rat Human -DTXSID6046426 Css NA 0.02126 mg/L PBTK NA 95% Rat Human -DTXSID6046428 Clint NA 12.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046428 Fup NA 0.0663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046428 Vd NA 0.3286 L/kg 1compartment NA NA Human Human +DTXSID6046426 TK.Half.Life NA 1.686 hours 1compartment NA NA Rat Human +DTXSID6046426 Css NA 4.991e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046426 Css NA 0.0006953 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046426 Css NA 7.469e-05 mg/L PBTK NA 50% Rat Human +DTXSID6046426 Css NA 0.0007295 mg/L PBTK NA 95% Rat Human +DTXSID6046428 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046428 Fup 0.0412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046428 Vd NA 0.3008 L/kg 1compartment NA NA Human Human DTXSID6046428 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046428 TK.Half.Life NA 1.695 hours 1compartment NA NA Human Human -DTXSID6046428 Css NA 0.7489 mg/L 3compartmentss NA 50% Human Human -DTXSID6046428 Css NA 5.716 mg/L 3compartmentss NA 95% Human Human -DTXSID6046428 Css NA 0.4679 mg/L PBTK NA 50% Human Human -DTXSID6046428 Css NA 3.442 mg/L PBTK NA 95% Human Human -DTXSID6046428 Clint NA 12.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046428 Fup NA 0.0663 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046428 Vd NA 0.3162 L/kg 1compartment NA NA Rat Human +DTXSID6046428 TK.Half.Life NA 1.528 hours 1compartment NA NA Human Human +DTXSID6046428 Css NA 0.7666 mg/L 3compartmentss NA 50% Human Human +DTXSID6046428 Css NA 7.352 mg/L 3compartmentss NA 95% Human Human +DTXSID6046428 Css NA 0.4694 mg/L PBTK NA 50% Human Human +DTXSID6046428 Css NA 4.396 mg/L PBTK NA 95% Human Human +DTXSID6046428 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046428 Fup 0.0412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046428 Vd NA 0.286 L/kg 1compartment NA NA Rat Human DTXSID6046428 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046428 TK.Half.Life NA 1.022 hours 1compartment NA NA Rat Human -DTXSID6046428 Css NA 0.4218 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046428 Css NA 2.317 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046428 Css NA 0.2464 mg/L PBTK NA 50% Rat Human -DTXSID6046428 Css NA 1.303 mg/L PBTK NA 95% Rat Human -DTXSID6046470 Clint NA 115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046470 Fup NA 0.0287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046470 Vd NA 2.786 L/kg 1compartment NA NA Human Human -DTXSID6046470 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046470 TK.Half.Life NA 8.66 hours 1compartment NA NA Human Human -DTXSID6046470 Css NA 0.3278 mg/L 3compartmentss NA 50% Human Human -DTXSID6046470 Css NA 2.197 mg/L 3compartmentss NA 95% Human Human -DTXSID6046470 Css NA 0.2222 mg/L PBTK NA 50% Human Human -DTXSID6046470 Css NA 1.429 mg/L PBTK NA 95% Human Human -DTXSID6046470 Clint NA 115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046470 Fup NA 0.0287 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046470 Vd NA 2.084 L/kg 1compartment NA NA Rat Human -DTXSID6046470 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046470 TK.Half.Life NA 1.986 hours 1compartment NA NA Rat Human -DTXSID6046470 Css NA 0.1824 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046470 Css NA 1.046 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046470 Css NA 0.1174 mg/L PBTK NA 50% Rat Human -DTXSID6046470 Css NA 0.6525 mg/L PBTK NA 95% Rat Human -DTXSID6046472 Clint NA 117.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046472 Fup NA 0.0106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046472 Vd NA 7.331 L/kg 1compartment NA NA Human Human +DTXSID6046428 TK.Half.Life NA 0.9242 hours 1compartment NA NA Rat Human +DTXSID6046428 Css NA 0.1016 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046428 Css NA 0.767 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046428 Css NA 0.06013 mg/L PBTK NA 50% Rat Human +DTXSID6046428 Css NA 0.4378 mg/L PBTK NA 95% Rat Human +DTXSID6046470 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046470 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046470 Vd NA 2.146 L/kg 1compartment NA NA Human Human +DTXSID6046470 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6046470 TK.Half.Life NA 28.83 hours 1compartment NA NA Human Human +DTXSID6046470 Css NA 2.018 mg/L 3compartmentss NA 50% Human Human +DTXSID6046470 Css NA 16.3 mg/L 3compartmentss NA 95% Human Human +DTXSID6046470 Css NA 1.298 mg/L PBTK NA 50% Human Human +DTXSID6046470 Css NA 10.03 mg/L PBTK NA 95% Human Human +DTXSID6046470 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046470 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046470 Vd NA 1.594 L/kg 1compartment NA NA Rat Human +DTXSID6046470 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6046470 TK.Half.Life NA 8.645 hours 1compartment NA NA Rat Human +DTXSID6046470 Css NA 0.2573 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046470 Css NA 1.662 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046470 Css NA 0.1626 mg/L PBTK NA 50% Rat Human +DTXSID6046470 Css NA 1.02 mg/L PBTK NA 95% Rat Human +DTXSID6046472 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046472 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046472 Vd NA 7.43 L/kg 1compartment NA NA Human Human DTXSID6046472 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046472 TK.Half.Life NA 6.123 hours 1compartment NA NA Human Human -DTXSID6046472 Css NA 0.02984 mg/L 3compartmentss NA 50% Human Human -DTXSID6046472 Css NA 0.2404 mg/L 3compartmentss NA 95% Human Human -DTXSID6046472 Css NA 0.02882 mg/L PBTK NA 50% Human Human -DTXSID6046472 Css NA 0.2008 mg/L PBTK NA 95% Human Human -DTXSID6046472 Clint NA 117.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046472 Fup NA 0.0106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046472 Vd NA 5.78 L/kg 1compartment NA NA Rat Human +DTXSID6046472 TK.Half.Life NA 14.25 hours 1compartment NA NA Human Human +DTXSID6046472 Css NA 0.1275 mg/L 3compartmentss NA 50% Human Human +DTXSID6046472 Css NA 0.9513 mg/L 3compartmentss NA 95% Human Human +DTXSID6046472 Css NA 0.126 mg/L PBTK NA 50% Human Human +DTXSID6046472 Css NA 0.8262 mg/L PBTK NA 95% Human Human +DTXSID6046472 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046472 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046472 Vd NA 5.872 L/kg 1compartment NA NA Rat Human DTXSID6046472 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046472 TK.Half.Life NA 1.877 hours 1compartment NA NA Rat Human -DTXSID6046472 Css NA 0.01606 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046472 Css NA 0.1134 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046472 Css NA 0.01536 mg/L PBTK NA 50% Rat Human -DTXSID6046472 Css NA 0.09234 mg/L PBTK NA 95% Rat Human -DTXSID6046474 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046474 Fup NA 0.0547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046474 Vd NA 0.2321 L/kg 1compartment NA NA Human Human +DTXSID6046472 TK.Half.Life NA 3.323 hours 1compartment NA NA Rat Human +DTXSID6046472 Css NA 0.0157 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046472 Css NA 0.1051 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046472 Css NA 0.01602 mg/L PBTK NA 50% Rat Human +DTXSID6046472 Css NA 0.09657 mg/L PBTK NA 95% Rat Human +DTXSID6046474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046474 Fup 0.0697 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046474 Vd NA 0.2338 L/kg 1compartment NA NA Human Human DTXSID6046474 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046474 TK.Half.Life NA 1.398 hours 1compartment NA NA Human Human -DTXSID6046474 Css NA 0.9789 mg/L 3compartmentss NA 50% Human Human -DTXSID6046474 Css NA 6.943 mg/L 3compartmentss NA 95% Human Human -DTXSID6046474 Css NA 0.584 mg/L PBTK NA 50% Human Human -DTXSID6046474 Css NA 4.103 mg/L PBTK NA 95% Human Human -DTXSID6046474 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046474 Fup NA 0.0547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046474 Vd NA 0.2252 L/kg 1compartment NA NA Rat Human +DTXSID6046474 TK.Half.Life NA 0.7955 hours 1compartment NA NA Human Human +DTXSID6046474 Css NA 0.392 mg/L 3compartmentss NA 50% Human Human +DTXSID6046474 Css NA 3.099 mg/L 3compartmentss NA 95% Human Human +DTXSID6046474 Css NA 0.235 mg/L PBTK NA 50% Human Human +DTXSID6046474 Css NA 1.83 mg/L PBTK NA 95% Human Human +DTXSID6046474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046474 Fup 0.0697 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046474 Vd NA 0.2292 L/kg 1compartment NA NA Rat Human DTXSID6046474 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046474 TK.Half.Life NA 0.8572 hours 1compartment NA NA Rat Human -DTXSID6046474 Css NA 0.523 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046474 Css NA 3.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046474 Css NA 0.2922 mg/L PBTK NA 50% Rat Human -DTXSID6046474 Css NA 1.682 mg/L PBTK NA 95% Rat Human -DTXSID6046476 Clint NA 41.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046476 Fup NA 0.0175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046476 Vd NA 0.2026 L/kg 1compartment NA NA Human Human +DTXSID6046474 TK.Half.Life NA 0.4774 hours 1compartment NA NA Rat Human +DTXSID6046474 Css NA 0.01913 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046474 Css NA 0.1632 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046474 Css NA 0.01092 mg/L PBTK NA 50% Rat Human +DTXSID6046474 Css NA 0.0928 mg/L PBTK NA 95% Rat Human +DTXSID6046476 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046476 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046476 Vd NA 0.2606 L/kg 1compartment NA NA Human Human DTXSID6046476 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046476 TK.Half.Life NA 1.26 hours 1compartment NA NA Human Human -DTXSID6046476 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human -DTXSID6046476 Css NA 10.28 mg/L 3compartmentss NA 95% Human Human -DTXSID6046476 Css NA 0.6003 mg/L PBTK NA 50% Human Human -DTXSID6046476 Css NA 5.979 mg/L PBTK NA 95% Human Human -DTXSID6046476 Clint NA 41.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046476 Fup NA 0.0175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046476 Vd NA 0.1974 L/kg 1compartment NA NA Rat Human +DTXSID6046476 TK.Half.Life NA 1.362 hours 1compartment NA NA Human Human +DTXSID6046476 Css NA 0.7018 mg/L 3compartmentss NA 50% Human Human +DTXSID6046476 Css NA 6.847 mg/L 3compartmentss NA 95% Human Human +DTXSID6046476 Css NA 0.4252 mg/L PBTK NA 50% Human Human +DTXSID6046476 Css NA 4.06 mg/L PBTK NA 95% Human Human +DTXSID6046476 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046476 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046476 Vd NA 0.2519 L/kg 1compartment NA NA Rat Human DTXSID6046476 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046476 TK.Half.Life NA 0.7997 hours 1compartment NA NA Rat Human -DTXSID6046476 Css NA 0.5788 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046476 Css NA 4.806 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046476 Css NA 0.318 mg/L PBTK NA 50% Rat Human -DTXSID6046476 Css NA 2.617 mg/L PBTK NA 95% Rat Human -DTXSID6046478 Clint NA 11.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6046476 TK.Half.Life NA 0.8387 hours 1compartment NA NA Rat Human +DTXSID6046476 Css NA 0.03475 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046476 Css NA 0.3656 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046476 Css NA 0.02014 mg/L PBTK NA 50% Rat Human +DTXSID6046476 Css NA 0.2058 mg/L PBTK NA 95% Rat Human +DTXSID6046478 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID6046478 Fup 0.023 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6046478 Vd NA 0.9402 L/kg 1compartment NA NA Human Human -DTXSID6046478 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6046478 TK.Half.Life NA 12.76 hours 1compartment NA NA Human Human -DTXSID6046478 Css NA 2.318 mg/L 3compartmentss NA 50% Human Human -DTXSID6046478 Css NA 19.99 mg/L 3compartmentss NA 95% Human Human -DTXSID6046478 Css NA 1.421 mg/L PBTK NA 50% Human Human -DTXSID6046478 Css NA 11.97 mg/L PBTK NA 95% Human Human -DTXSID6046478 Clint NA 11.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6046478 Vd NA 0.684 L/kg 1compartment NA NA Human Human +DTXSID6046478 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6046478 TK.Half.Life NA 24.12 hours 1compartment NA NA Human Human +DTXSID6046478 Css NA 6.107 mg/L 3compartmentss NA 50% Human Human +DTXSID6046478 Css NA 49.31 mg/L 3compartmentss NA 95% Human Human +DTXSID6046478 Css NA 3.666 mg/L PBTK NA 50% Human Human +DTXSID6046478 Css NA 29.13 mg/L PBTK NA 95% Human Human +DTXSID6046478 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID6046478 Fup 0.023 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6046478 Vd NA 0.7047 L/kg 1compartment NA NA Rat Human -DTXSID6046478 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046478 TK.Half.Life NA 5.672 hours 1compartment NA NA Rat Human -DTXSID6046478 Css NA 1.304 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046478 Css NA 8.896 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046478 Css NA 0.7451 mg/L PBTK NA 50% Rat Human -DTXSID6046478 Css NA 4.886 mg/L PBTK NA 95% Rat Human -DTXSID6046501 Clint NA 9.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046501 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046501 Vd NA 0.2329 L/kg 1compartment NA NA Human Human +DTXSID6046478 Vd NA 0.5218 L/kg 1compartment NA NA Rat Human +DTXSID6046478 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6046478 TK.Half.Life NA 10.8 hours 1compartment NA NA Rat Human +DTXSID6046478 Css NA 0.7388 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046478 Css NA 4.57 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046478 Css NA 0.4319 mg/L PBTK NA 50% Rat Human +DTXSID6046478 Css NA 2.596 mg/L PBTK NA 95% Rat Human +DTXSID6046501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046501 Fup 0.0304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046501 Vd NA 0.3323 L/kg 1compartment NA NA Human Human DTXSID6046501 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046501 TK.Half.Life NA 6.691 hours 1compartment NA NA Human Human -DTXSID6046501 Css NA 5.343 mg/L 3compartmentss NA 50% Human Human -DTXSID6046501 Css NA 45.76 mg/L 3compartmentss NA 95% Human Human -DTXSID6046501 Css NA 3.157 mg/L PBTK NA 50% Human Human -DTXSID6046501 Css NA 26.51 mg/L PBTK NA 95% Human Human -DTXSID6046501 Clint NA 9.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046501 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046501 Vd NA 0.2118 L/kg 1compartment NA NA Rat Human +DTXSID6046501 TK.Half.Life NA 2.149 hours 1compartment NA NA Human Human +DTXSID6046501 Css NA 1.014 mg/L 3compartmentss NA 50% Human Human +DTXSID6046501 Css NA 10.05 mg/L 3compartmentss NA 95% Human Human +DTXSID6046501 Css NA 0.6092 mg/L PBTK NA 50% Human Human +DTXSID6046501 Css NA 5.839 mg/L PBTK NA 95% Human Human +DTXSID6046501 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046501 Fup 0.0304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046501 Vd NA 0.2883 L/kg 1compartment NA NA Rat Human DTXSID6046501 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046501 TK.Half.Life NA 3.965 hours 1compartment NA NA Rat Human -DTXSID6046501 Css NA 2.901 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046501 Css NA 20.64 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046501 Css NA 1.591 mg/L PBTK NA 50% Rat Human -DTXSID6046501 Css NA 11.19 mg/L PBTK NA 95% Rat Human -DTXSID6046503 Clint NA 92.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046503 Fup NA 0.034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046503 Vd NA 2.783 L/kg 1compartment NA NA Human Human -DTXSID6046503 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046503 TK.Half.Life NA 9.437 hours 1compartment NA NA Human Human -DTXSID6046503 Css NA 0.3624 mg/L 3compartmentss NA 50% Human Human -DTXSID6046503 Css NA 2.396 mg/L 3compartmentss NA 95% Human Human -DTXSID6046503 Css NA 0.2463 mg/L PBTK NA 50% Human Human -DTXSID6046503 Css NA 1.572 mg/L PBTK NA 95% Human Human -DTXSID6046503 Clint NA 92.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046503 Fup NA 0.034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046503 Vd NA 2.084 L/kg 1compartment NA NA Rat Human +DTXSID6046501 TK.Half.Life NA 1.196 hours 1compartment NA NA Rat Human +DTXSID6046501 Css NA 0.1344 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046501 Css NA 1.03 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046501 Css NA 0.07812 mg/L PBTK NA 50% Rat Human +DTXSID6046501 Css NA 0.5808 mg/L PBTK NA 95% Rat Human +DTXSID6046503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046503 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046503 Vd NA 1.612 L/kg 1compartment NA NA Human Human +DTXSID6046503 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6046503 TK.Half.Life NA 12.59 hours 1compartment NA NA Human Human +DTXSID6046503 Css NA 1.156 mg/L 3compartmentss NA 50% Human Human +DTXSID6046503 Css NA 10.19 mg/L 3compartmentss NA 95% Human Human +DTXSID6046503 Css NA 0.7273 mg/L PBTK NA 50% Human Human +DTXSID6046503 Css NA 6.207 mg/L PBTK NA 95% Human Human +DTXSID6046503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046503 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046503 Vd NA 1.2 L/kg 1compartment NA NA Rat Human DTXSID6046503 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046503 TK.Half.Life NA 2.141 hours 1compartment NA NA Rat Human -DTXSID6046503 Css NA 0.2024 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046503 Css NA 1.108 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046503 Css NA 0.1307 mg/L PBTK NA 50% Rat Human -DTXSID6046503 Css NA 0.7106 mg/L PBTK NA 95% Rat Human -DTXSID6046505 Clint NA 29.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046505 Fup NA 0.2852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046505 Vd NA 2.4 L/kg 1compartment NA NA Human Human +DTXSID6046503 TK.Half.Life NA 4.687 hours 1compartment NA NA Rat Human +DTXSID6046503 Css NA 0.1509 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046503 Css NA 1.112 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046503 Css NA 0.09284 mg/L PBTK NA 50% Rat Human +DTXSID6046503 Css NA 0.648 mg/L PBTK NA 95% Rat Human +DTXSID6046505 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046505 Fup 0.373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046505 Vd NA 2.629 L/kg 1compartment NA NA Human Human DTXSID6046505 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046505 TK.Half.Life NA 2.276 hours 1compartment NA NA Human Human -DTXSID6046505 Css NA 0.03803 mg/L 3compartmentss NA 50% Human Human -DTXSID6046505 Css NA 0.3286 mg/L 3compartmentss NA 95% Human Human -DTXSID6046505 Css NA 0.03745 mg/L PBTK NA 50% Human Human -DTXSID6046505 Css NA 0.2627 mg/L PBTK NA 95% Human Human -DTXSID6046505 Clint NA 29.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046505 Fup NA 0.2852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046505 Vd NA 2.415 L/kg 1compartment NA NA Rat Human +DTXSID6046505 TK.Half.Life NA 4.937 hours 1compartment NA NA Human Human +DTXSID6046505 Css NA 0.1168 mg/L 3compartmentss NA 50% Human Human +DTXSID6046505 Css NA 0.8885 mg/L 3compartmentss NA 95% Human Human +DTXSID6046505 Css NA 0.124 mg/L PBTK NA 50% Human Human +DTXSID6046505 Css NA 0.7328 mg/L PBTK NA 95% Human Human +DTXSID6046505 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046505 Fup 0.373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046505 Vd NA 2.652 L/kg 1compartment NA NA Rat Human DTXSID6046505 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046505 TK.Half.Life NA 1.234 hours 1compartment NA NA Rat Human -DTXSID6046505 Css NA 0.02033 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046505 Css NA 0.125 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046505 Css NA 0.0198 mg/L PBTK NA 50% Rat Human -DTXSID6046505 Css NA 0.1016 mg/L PBTK NA 95% Rat Human -DTXSID6046507 Clint NA 17.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046507 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046507 Vd NA 1.557 L/kg 1compartment NA NA Human Human +DTXSID6046505 TK.Half.Life NA 2.899 hours 1compartment NA NA Rat Human +DTXSID6046505 Css NA 0.01317 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046505 Css NA 0.07934 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046505 Css NA 0.01438 mg/L PBTK NA 50% Rat Human +DTXSID6046505 Css NA 0.06333 mg/L PBTK NA 95% Rat Human +DTXSID6046507 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046507 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046507 Vd NA 1.123 L/kg 1compartment NA NA Human Human DTXSID6046507 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046507 TK.Half.Life NA 3.769 hours 1compartment NA NA Human Human -DTXSID6046507 Css NA 0.2644 mg/L 3compartmentss NA 50% Human Human -DTXSID6046507 Css NA 3.055 mg/L 3compartmentss NA 95% Human Human -DTXSID6046507 Css NA 0.1884 mg/L PBTK NA 50% Human Human -DTXSID6046507 Css NA 1.914 mg/L PBTK NA 95% Human Human -DTXSID6046507 Clint NA 17.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046507 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046507 Vd NA 1.448 L/kg 1compartment NA NA Rat Human +DTXSID6046507 TK.Half.Life NA 3.853 hours 1compartment NA NA Human Human +DTXSID6046507 Css NA 0.432 mg/L 3compartmentss NA 50% Human Human +DTXSID6046507 Css NA 4.975 mg/L 3compartmentss NA 95% Human Human +DTXSID6046507 Css NA 0.2888 mg/L PBTK NA 50% Human Human +DTXSID6046507 Css NA 3.041 mg/L PBTK NA 95% Human Human +DTXSID6046507 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046507 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046507 Vd NA 1.065 L/kg 1compartment NA NA Rat Human DTXSID6046507 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046507 TK.Half.Life NA 2.067 hours 1compartment NA NA Rat Human -DTXSID6046507 Css NA 0.1495 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046507 Css NA 1.469 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046507 Css NA 0.1001 mg/L PBTK NA 50% Rat Human -DTXSID6046507 Css NA 0.8643 mg/L PBTK NA 95% Rat Human -DTXSID6046509 Clint NA 11.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046509 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046509 Vd NA 0.2794 L/kg 1compartment NA NA Human Human +DTXSID6046507 TK.Half.Life NA 2.282 hours 1compartment NA NA Rat Human +DTXSID6046507 Css NA 0.05757 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046507 Css NA 0.5305 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046507 Css NA 0.03753 mg/L PBTK NA 50% Rat Human +DTXSID6046507 Css NA 0.3147 mg/L PBTK NA 95% Rat Human +DTXSID6046509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046509 Fup 0.0772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046509 Vd NA 0.4271 L/kg 1compartment NA NA Human Human DTXSID6046509 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046509 TK.Half.Life NA 2.564 hours 1compartment NA NA Human Human -DTXSID6046509 Css NA 1.618 mg/L 3compartmentss NA 50% Human Human -DTXSID6046509 Css NA 11.8 mg/L 3compartmentss NA 95% Human Human -DTXSID6046509 Css NA 0.9662 mg/L PBTK NA 50% Human Human -DTXSID6046509 Css NA 6.929 mg/L PBTK NA 95% Human Human -DTXSID6046509 Clint NA 11.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046509 Fup NA 0.0367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046509 Vd NA 0.2543 L/kg 1compartment NA NA Rat Human +DTXSID6046509 TK.Half.Life NA 1.315 hours 1compartment NA NA Human Human +DTXSID6046509 Css NA 0.3745 mg/L 3compartmentss NA 50% Human Human +DTXSID6046509 Css NA 2.874 mg/L 3compartmentss NA 95% Human Human +DTXSID6046509 Css NA 0.2336 mg/L PBTK NA 50% Human Human +DTXSID6046509 Css NA 1.73 mg/L PBTK NA 95% Human Human +DTXSID6046509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046509 Fup 0.0772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046509 Vd NA 0.3752 L/kg 1compartment NA NA Rat Human DTXSID6046509 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046509 TK.Half.Life NA 1.498 hours 1compartment NA NA Rat Human -DTXSID6046509 Css NA 0.9064 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046509 Css NA 5.078 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046509 Css NA 0.5052 mg/L PBTK NA 50% Rat Human -DTXSID6046509 Css NA 2.79 mg/L PBTK NA 95% Rat Human -DTXSID6046551 Clint NA 10.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046551 Fup NA 0.1192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046551 Vd NA 2.366 L/kg 1compartment NA NA Human Human -DTXSID6046551 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6046551 TK.Half.Life NA 14.63 hours 1compartment NA NA Human Human -DTXSID6046551 Css NA 0.7613 mg/L 3compartmentss NA 50% Human Human -DTXSID6046551 Css NA 4.825 mg/L 3compartmentss NA 95% Human Human -DTXSID6046551 Css NA 0.5264 mg/L PBTK NA 50% Human Human -DTXSID6046551 Css NA 3.115 mg/L PBTK NA 95% Human Human -DTXSID6046551 Clint NA 10.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046551 Fup NA 0.1192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046551 Vd NA 1.789 L/kg 1compartment NA NA Rat Human +DTXSID6046509 TK.Half.Life NA 0.6967 hours 1compartment NA NA Rat Human +DTXSID6046509 Css NA 0.0489 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046509 Css NA 0.2957 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046509 Css NA 0.02961 mg/L PBTK NA 50% Rat Human +DTXSID6046509 Css NA 0.1718 mg/L PBTK NA 95% Rat Human +DTXSID6046551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046551 Fup 0.0901 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046551 Vd NA 2.068 L/kg 1compartment NA NA Human Human +DTXSID6046551 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046551 TK.Half.Life NA 7.589 hours 1compartment NA NA Human Human +DTXSID6046551 Css NA 0.4156 mg/L 3compartmentss NA 50% Human Human +DTXSID6046551 Css NA 2.933 mg/L 3compartmentss NA 95% Human Human +DTXSID6046551 Css NA 0.28 mg/L PBTK NA 50% Human Human +DTXSID6046551 Css NA 1.892 mg/L PBTK NA 95% Human Human +DTXSID6046551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046551 Fup 0.0901 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046551 Vd NA 1.562 L/kg 1compartment NA NA Rat Human DTXSID6046551 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046551 TK.Half.Life NA 4.032 hours 1compartment NA NA Rat Human -DTXSID6046551 Css NA 0.4125 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046551 Css NA 1.905 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046551 Css NA 0.2713 mg/L PBTK NA 50% Rat Human -DTXSID6046551 Css NA 1.196 mg/L PBTK NA 95% Rat Human -DTXSID6046553 Clint NA 70.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046553 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046553 Vd NA 19.49 L/kg 1compartment NA NA Human Human -DTXSID6046553 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID6046553 TK.Half.Life NA 181.6 hours 1compartment NA NA Human Human -DTXSID6046553 Css NA 0.3651 mg/L 3compartmentss NA 50% Human Human -DTXSID6046553 Css NA 2.293 mg/L 3compartmentss NA 95% Human Human -DTXSID6046553 Css NA 0.7574 mg/L PBTK NA 50% Human Human -DTXSID6046553 Css NA 4.367 mg/L PBTK NA 95% Human Human -DTXSID6046553 Clint NA 70.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046553 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046553 Vd NA 15.8 L/kg 1compartment NA NA Rat Human -DTXSID6046553 Days.Css NA 21 Days PBTK NA NA Rat Human -DTXSID6046553 TK.Half.Life NA 26.48 hours 1compartment NA NA Rat Human -DTXSID6046553 Css NA 0.1936 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046553 Css NA 0.8794 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046553 Css NA 0.4104 mg/L PBTK NA 50% Rat Human -DTXSID6046553 Css NA 1.861 mg/L PBTK NA 95% Rat Human -DTXSID6046555 Clint NA 28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046555 Fup NA 0.0609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046555 Vd NA 0.966 L/kg 1compartment NA NA Human Human +DTXSID6046551 TK.Half.Life NA 2.447 hours 1compartment NA NA Rat Human +DTXSID6046551 Css NA 0.05332 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046551 Css NA 0.296 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046551 Css NA 0.0353 mg/L PBTK NA 50% Rat Human +DTXSID6046551 Css NA 0.1885 mg/L PBTK NA 95% Rat Human +DTXSID6046553 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046553 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046553 Vd NA 5.126 L/kg 1compartment NA NA Human Human +DTXSID6046553 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID6046553 TK.Half.Life NA 154 hours 1compartment NA NA Human Human +DTXSID6046553 Css NA 2.917 mg/L 3compartmentss NA 50% Human Human +DTXSID6046553 Css NA 18.05 mg/L 3compartmentss NA 95% Human Human +DTXSID6046553 Css NA 2.392 mg/L PBTK NA 50% Human Human +DTXSID6046553 Css NA 14.57 mg/L PBTK NA 95% Human Human +DTXSID6046553 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046553 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046553 Vd NA 3.918 L/kg 1compartment NA NA Rat Human +DTXSID6046553 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID6046553 TK.Half.Life NA 21.24 hours 1compartment NA NA Rat Human +DTXSID6046553 Css NA 0.3792 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046553 Css NA 1.953 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046553 Css NA 0.3112 mg/L PBTK NA 50% Rat Human +DTXSID6046553 Css NA 1.618 mg/L PBTK NA 95% Rat Human +DTXSID6046555 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046555 Fup 0.0421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046555 Vd NA 1.121 L/kg 1compartment NA NA Human Human DTXSID6046555 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046555 TK.Half.Life NA 3.007 hours 1compartment NA NA Human Human -DTXSID6046555 Css NA 0.4027 mg/L 3compartmentss NA 50% Human Human -DTXSID6046555 Css NA 3.25 mg/L 3compartmentss NA 95% Human Human -DTXSID6046555 Css NA 0.2529 mg/L PBTK NA 50% Human Human -DTXSID6046555 Css NA 1.972 mg/L PBTK NA 95% Human Human -DTXSID6046555 Clint NA 28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046555 Fup NA 0.0609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046555 Vd NA 0.7399 L/kg 1compartment NA NA Rat Human +DTXSID6046555 TK.Half.Life NA 5.635 hours 1compartment NA NA Human Human +DTXSID6046555 Css NA 0.7376 mg/L 3compartmentss NA 50% Human Human +DTXSID6046555 Css NA 6.048 mg/L 3compartmentss NA 95% Human Human +DTXSID6046555 Css NA 0.4632 mg/L PBTK NA 50% Human Human +DTXSID6046555 Css NA 3.582 mg/L PBTK NA 95% Human Human +DTXSID6046555 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046555 Fup 0.0421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046555 Vd NA 0.8428 L/kg 1compartment NA NA Rat Human DTXSID6046555 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046555 TK.Half.Life NA 1.301 hours 1compartment NA NA Rat Human -DTXSID6046555 Css NA 0.229 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046555 Css NA 1.383 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046555 Css NA 0.1354 mg/L PBTK NA 50% Rat Human -DTXSID6046555 Css NA 0.7865 mg/L PBTK NA 95% Rat Human -DTXSID6046557 Clint NA 0.6368 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046557 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046557 Vd NA 0.2437 L/kg 1compartment NA NA Human Human -DTXSID6046557 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6046557 TK.Half.Life NA 30.64 hours 1compartment NA NA Human Human -DTXSID6046557 Css NA 21.37 mg/L 3compartmentss NA 50% Human Human -DTXSID6046557 Css NA 138 mg/L 3compartmentss NA 95% Human Human -DTXSID6046557 Css NA 12.74 mg/L PBTK NA 50% Human Human -DTXSID6046557 Css NA 80.41 mg/L PBTK NA 95% Human Human -DTXSID6046557 Clint NA 0.6368 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046557 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046557 Vd NA 0.2385 L/kg 1compartment NA NA Rat Human -DTXSID6046557 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6046557 TK.Half.Life NA 13.87 hours 1compartment NA NA Rat Human -DTXSID6046557 Css NA 8.348 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046557 Css NA 46.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046557 Css NA 4.642 mg/L PBTK NA 50% Rat Human -DTXSID6046557 Css NA 25.42 mg/L PBTK NA 95% Rat Human -DTXSID6046630 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6046555 TK.Half.Life NA 2.38 hours 1compartment NA NA Rat Human +DTXSID6046555 Css NA 0.09869 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046555 Css NA 0.5893 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046555 Css NA 0.05985 mg/L PBTK NA 50% Rat Human +DTXSID6046555 Css NA 0.3481 mg/L PBTK NA 95% Rat Human +DTXSID6046557 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046557 Fup 0.0832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046557 Vd NA 0.3998 L/kg 1compartment NA NA Human Human +DTXSID6046557 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046557 TK.Half.Life NA 3.031 hours 1compartment NA NA Human Human +DTXSID6046557 Css NA 1.116 mg/L 3compartmentss NA 50% Human Human +DTXSID6046557 Css NA 7.893 mg/L 3compartmentss NA 95% Human Human +DTXSID6046557 Css NA 0.7091 mg/L PBTK NA 50% Human Human +DTXSID6046557 Css NA 4.739 mg/L PBTK NA 95% Human Human +DTXSID6046557 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046557 Fup 0.0832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046557 Vd NA 0.3931 L/kg 1compartment NA NA Rat Human +DTXSID6046557 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6046557 TK.Half.Life NA 1.835 hours 1compartment NA NA Rat Human +DTXSID6046557 Css NA 0.136 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046557 Css NA 0.6828 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046557 Css NA 0.08477 mg/L PBTK NA 50% Rat Human +DTXSID6046557 Css NA 0.3983 mg/L PBTK NA 95% Rat Human +DTXSID6046630 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6046630 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6046630 Vd NA 0.2273 L/kg 1compartment NA NA Human Human -DTXSID6046630 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID6046630 TK.Half.Life NA 49.06 hours 1compartment NA NA Human Human -DTXSID6046630 Css NA 37.21 mg/L 3compartmentss NA 50% Human Human -DTXSID6046630 Css NA 218.7 mg/L 3compartmentss NA 95% Human Human -DTXSID6046630 Css NA 21.85 mg/L PBTK NA 50% Human Human -DTXSID6046630 Css NA 125.3 mg/L PBTK NA 95% Human Human -DTXSID6046630 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6046630 Vd NA 0.1876 L/kg 1compartment NA NA Human Human +DTXSID6046630 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046630 TK.Half.Life NA 3.695 hours 1compartment NA NA Human Human +DTXSID6046630 Css NA 1.888 mg/L 3compartmentss NA 50% Human Human +DTXSID6046630 Css NA 17.35 mg/L 3compartmentss NA 95% Human Human +DTXSID6046630 Css NA 1.109 mg/L PBTK NA 50% Human Human +DTXSID6046630 Css NA 10.01 mg/L PBTK NA 95% Human Human +DTXSID6046630 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6046630 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6046630 Vd NA 0.2187 L/kg 1compartment NA NA Rat Human -DTXSID6046630 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6046630 TK.Half.Life NA 16.08 hours 1compartment NA NA Rat Human -DTXSID6046630 Css NA 10.59 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046630 Css NA 52.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046630 Css NA 5.826 mg/L PBTK NA 50% Rat Human -DTXSID6046630 Css NA 28.66 mg/L PBTK NA 95% Rat Human -DTXSID6046634 Clint NA 5.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046634 Fup NA 0.0907 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046634 Vd NA 0.3616 L/kg 1compartment NA NA Human Human +DTXSID6046630 Vd NA 0.1873 L/kg 1compartment NA NA Rat Human +DTXSID6046630 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6046630 TK.Half.Life NA 2.328 hours 1compartment NA NA Rat Human +DTXSID6046630 Css NA 0.01996 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046630 Css NA 0.1528 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046630 Css NA 0.01098 mg/L PBTK NA 50% Rat Human +DTXSID6046630 Css NA 0.0833 mg/L PBTK NA 95% Rat Human +DTXSID6046634 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046634 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046634 Vd NA 0.5507 L/kg 1compartment NA NA Human Human DTXSID6046634 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046634 TK.Half.Life NA 2.971 hours 1compartment NA NA Human Human -DTXSID6046634 Css NA 1.245 mg/L 3compartmentss NA 50% Human Human -DTXSID6046634 Css NA 8.241 mg/L 3compartmentss NA 95% Human Human -DTXSID6046634 Css NA 0.7919 mg/L PBTK NA 50% Human Human -DTXSID6046634 Css NA 4.967 mg/L PBTK NA 95% Human Human -DTXSID6046634 Clint NA 5.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046634 Fup NA 0.0907 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046634 Vd NA 0.3537 L/kg 1compartment NA NA Rat Human +DTXSID6046634 TK.Half.Life NA 2.326 hours 1compartment NA NA Human Human +DTXSID6046634 Css NA 0.4619 mg/L 3compartmentss NA 50% Human Human +DTXSID6046634 Css NA 3.118 mg/L 3compartmentss NA 95% Human Human +DTXSID6046634 Css NA 0.3307 mg/L PBTK NA 50% Human Human +DTXSID6046634 Css NA 2.011 mg/L PBTK NA 95% Human Human +DTXSID6046634 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046634 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046634 Vd NA 0.5384 L/kg 1compartment NA NA Rat Human DTXSID6046634 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046634 TK.Half.Life NA 1.766 hours 1compartment NA NA Rat Human -DTXSID6046634 Css NA 0.6438 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046634 Css NA 3.199 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046634 Css NA 0.3854 mg/L PBTK NA 50% Rat Human -DTXSID6046634 Css NA 1.797 mg/L PBTK NA 95% Rat Human -DTXSID6046636 Clint NA 0.3016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046636 Fup NA 0.043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046636 Vd NA 2.178 L/kg 1compartment NA NA Human Human -DTXSID6046636 Days.Css NA 94 Days PBTK NA NA Human Human -DTXSID6046636 TK.Half.Life NA 402.8 hours 1compartment NA NA Human Human -DTXSID6046636 Css NA 25.77 mg/L 3compartmentss NA 50% Human Human -DTXSID6046636 Css NA 95.17 mg/L 3compartmentss NA 95% Human Human -DTXSID6046636 Css NA 17.08 mg/L PBTK NA 50% Human Human -DTXSID6046636 Css NA 58.47 mg/L PBTK NA 95% Human Human -DTXSID6046636 Clint NA 0.3016 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046636 Fup NA 0.043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046636 Vd NA 1.633 L/kg 1compartment NA NA Rat Human -DTXSID6046636 Days.Css NA 29 Days PBTK NA NA Rat Human -DTXSID6046636 TK.Half.Life NA 77.69 hours 1compartment NA NA Rat Human -DTXSID6046636 Css NA 9.398 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046636 Css NA 27.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046636 Css NA 5.878 mg/L PBTK NA 50% Rat Human -DTXSID6046636 Css NA 15.85 mg/L PBTK NA 95% Rat Human -DTXSID6046638 Clint NA 7.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046638 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046638 Vd NA 0.3712 L/kg 1compartment NA NA Human Human -DTXSID6046638 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6046638 TK.Half.Life NA 23.41 hours 1compartment NA NA Human Human -DTXSID6046638 Css NA 11.79 mg/L 3compartmentss NA 50% Human Human -DTXSID6046638 Css NA 100.5 mg/L 3compartmentss NA 95% Human Human -DTXSID6046638 Css NA 7.081 mg/L PBTK NA 50% Human Human -DTXSID6046638 Css NA 58.66 mg/L PBTK NA 95% Human Human -DTXSID6046638 Clint NA 7.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046638 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046638 Vd NA 0.3119 L/kg 1compartment NA NA Rat Human +DTXSID6046634 TK.Half.Life NA 1.363 hours 1compartment NA NA Rat Human +DTXSID6046634 Css NA 0.0556 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046634 Css NA 0.2799 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046634 Css NA 0.03919 mg/L PBTK NA 50% Rat Human +DTXSID6046634 Css NA 0.1758 mg/L PBTK NA 95% Rat Human +DTXSID6046636 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046636 Fup 0.0951 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046636 Vd NA 1.74 L/kg 1compartment NA NA Human Human +DTXSID6046636 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046636 TK.Half.Life NA 5.415 hours 1compartment NA NA Human Human +DTXSID6046636 Css NA 0.3452 mg/L 3compartmentss NA 50% Human Human +DTXSID6046636 Css NA 2.542 mg/L 3compartmentss NA 95% Human Human +DTXSID6046636 Css NA 0.229 mg/L PBTK NA 50% Human Human +DTXSID6046636 Css NA 1.642 mg/L PBTK NA 95% Human Human +DTXSID6046636 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046636 Fup 0.0951 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046636 Vd NA 1.33 L/kg 1compartment NA NA Rat Human +DTXSID6046636 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6046636 TK.Half.Life NA 1.984 hours 1compartment NA NA Rat Human +DTXSID6046636 Css NA 0.04466 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046636 Css NA 0.2551 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046636 Css NA 0.02933 mg/L PBTK NA 50% Rat Human +DTXSID6046636 Css NA 0.1602 mg/L PBTK NA 95% Rat Human +DTXSID6046638 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046638 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046638 Vd NA 0.415 L/kg 1compartment NA NA Human Human +DTXSID6046638 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6046638 TK.Half.Life NA 19.92 hours 1compartment NA NA Human Human +DTXSID6046638 Css NA 8.343 mg/L 3compartmentss NA 50% Human Human +DTXSID6046638 Css NA 73.85 mg/L 3compartmentss NA 95% Human Human +DTXSID6046638 Css NA 5.077 mg/L PBTK NA 50% Human Human +DTXSID6046638 Css NA 43.2 mg/L PBTK NA 95% Human Human +DTXSID6046638 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046638 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046638 Vd NA 0.3506 L/kg 1compartment NA NA Rat Human DTXSID6046638 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6046638 TK.Half.Life NA 12.68 hours 1compartment NA NA Rat Human -DTXSID6046638 Css NA 6.303 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046638 Css NA 44.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046638 Css NA 3.514 mg/L PBTK NA 50% Rat Human -DTXSID6046638 Css NA 24.29 mg/L PBTK NA 95% Rat Human -DTXSID6046682 Clint NA 1125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046682 Fup NA 0.0235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046682 Vd NA 3.087 L/kg 1compartment NA NA Human Human -DTXSID6046682 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046682 TK.Half.Life NA 3.932 hours 1compartment NA NA Human Human -DTXSID6046682 Css NA 0.0581 mg/L 3compartmentss NA 50% Human Human -DTXSID6046682 Css NA 0.3646 mg/L 3compartmentss NA 95% Human Human -DTXSID6046682 Css NA 0.04036 mg/L PBTK NA 50% Human Human -DTXSID6046682 Css NA 0.2442 mg/L PBTK NA 95% Human Human -DTXSID6046682 Clint NA 1125 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046682 Fup NA 0.0235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046682 Vd NA 2.313 L/kg 1compartment NA NA Rat Human -DTXSID6046682 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046682 TK.Half.Life NA 1.022 hours 1compartment NA NA Rat Human -DTXSID6046682 Css NA 0.03264 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046682 Css NA 0.1715 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046682 Css NA 0.02164 mg/L PBTK NA 50% Rat Human -DTXSID6046682 Css NA 0.1097 mg/L PBTK NA 95% Rat Human -DTXSID6046686 Clint NA 3.109 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6046638 TK.Half.Life NA 10.68 hours 1compartment NA NA Rat Human +DTXSID6046638 Css NA 1.053 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046638 Css NA 7.321 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046638 Css NA 0.6182 mg/L PBTK NA 50% Rat Human +DTXSID6046638 Css NA 4.167 mg/L PBTK NA 95% Rat Human +DTXSID6046682 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046682 Fup 0.0616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046682 Vd NA 3.072 L/kg 1compartment NA NA Human Human +DTXSID6046682 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID6046682 TK.Half.Life NA 50.97 hours 1compartment NA NA Human Human +DTXSID6046682 Css NA 1.714 mg/L 3compartmentss NA 50% Human Human +DTXSID6046682 Css NA 11.56 mg/L 3compartmentss NA 95% Human Human +DTXSID6046682 Css NA 1.189 mg/L PBTK NA 50% Human Human +DTXSID6046682 Css NA 7.746 mg/L PBTK NA 95% Human Human +DTXSID6046682 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046682 Fup 0.0616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046682 Vd NA 2.304 L/kg 1compartment NA NA Rat Human +DTXSID6046682 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID6046682 TK.Half.Life NA 7.58 hours 1compartment NA NA Rat Human +DTXSID6046682 Css NA 0.08791 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046682 Css NA 0.5932 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046682 Css NA 0.05932 mg/L PBTK NA 50% Rat Human +DTXSID6046682 Css NA 0.3804 mg/L PBTK NA 95% Rat Human +DTXSID6046686 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID6046686 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6046686 Vd NA 0.1971 L/kg 1compartment NA NA Human Human -DTXSID6046686 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID6046686 TK.Half.Life NA 34.55 hours 1compartment NA NA Human Human -DTXSID6046686 Css NA 32.88 mg/L 3compartmentss NA 50% Human Human -DTXSID6046686 Css NA 245.7 mg/L 3compartmentss NA 95% Human Human -DTXSID6046686 Css NA 19.21 mg/L PBTK NA 50% Human Human -DTXSID6046686 Css NA 142.9 mg/L PBTK NA 95% Human Human -DTXSID6046686 Clint NA 3.109 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6046686 Vd NA 0.1999 L/kg 1compartment NA NA Human Human +DTXSID6046686 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID6046686 TK.Half.Life NA 35.58 hours 1compartment NA NA Human Human +DTXSID6046686 Css NA 32.11 mg/L 3compartmentss NA 50% Human Human +DTXSID6046686 Css NA 248.8 mg/L 3compartmentss NA 95% Human Human +DTXSID6046686 Css NA 18.86 mg/L PBTK NA 50% Human Human +DTXSID6046686 Css NA 144.7 mg/L PBTK NA 95% Human Human +DTXSID6046686 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID6046686 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6046686 Vd NA 0.1918 L/kg 1compartment NA NA Rat Human +DTXSID6046686 Vd NA 0.1909 L/kg 1compartment NA NA Rat Human DTXSID6046686 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6046686 TK.Half.Life NA 20.11 hours 1compartment NA NA Rat Human -DTXSID6046686 Css NA 16.11 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046686 Css NA 103.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046686 Css NA 8.808 mg/L PBTK NA 50% Rat Human -DTXSID6046686 Css NA 55.98 mg/L PBTK NA 95% Rat Human -DTXSID6046688 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046688 Fup NA 0.5158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046688 Vd NA 1.373 L/kg 1compartment NA NA Human Human +DTXSID6046686 TK.Half.Life NA 20.27 hours 1compartment NA NA Rat Human +DTXSID6046686 Css NA 3.698 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046686 Css NA 22.44 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046686 Css NA 2.094 mg/L PBTK NA 50% Rat Human +DTXSID6046686 Css NA 12.61 mg/L PBTK NA 95% Rat Human +DTXSID6046688 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046688 Fup 0.455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046688 Vd NA 1.197 L/kg 1compartment NA NA Human Human DTXSID6046688 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6046688 TK.Half.Life NA 17.22 hours 1compartment NA NA Human Human -DTXSID6046688 Css NA 1.234 mg/L 3compartmentss NA 50% Human Human -DTXSID6046688 Css NA 7.525 mg/L 3compartmentss NA 95% Human Human -DTXSID6046688 Css NA 1.089 mg/L PBTK NA 50% Human Human -DTXSID6046688 Css NA 4.999 mg/L PBTK NA 95% Human Human -DTXSID6046688 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046688 Fup NA 0.5158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046688 Vd NA 1.391 L/kg 1compartment NA NA Rat Human +DTXSID6046688 TK.Half.Life NA 17.02 hours 1compartment NA NA Human Human +DTXSID6046688 Css NA 0.7394 mg/L 3compartmentss NA 50% Human Human +DTXSID6046688 Css NA 4.039 mg/L 3compartmentss NA 95% Human Human +DTXSID6046688 Css NA 0.6354 mg/L PBTK NA 50% Human Human +DTXSID6046688 Css NA 2.722 mg/L PBTK NA 95% Human Human +DTXSID6046688 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046688 Fup 0.455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046688 Vd NA 1.213 L/kg 1compartment NA NA Rat Human DTXSID6046688 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046688 TK.Half.Life NA 5.945 hours 1compartment NA NA Rat Human -DTXSID6046688 Css NA 0.324 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046688 Css NA 1.784 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046688 Css NA 0.2793 mg/L PBTK NA 50% Rat Human -DTXSID6046688 Css NA 1.108 mg/L PBTK NA 95% Rat Human -DTXSID6046713 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046713 Fup NA 0.9501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046713 Vd NA 0.736 L/kg 1compartment NA NA Human Human +DTXSID6046688 TK.Half.Life NA 5.879 hours 1compartment NA NA Rat Human +DTXSID6046688 Css NA 0.003994 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046688 Css NA 0.02186 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046688 Css NA 0.003306 mg/L PBTK NA 50% Rat Human +DTXSID6046688 Css NA 0.01441 mg/L PBTK NA 95% Rat Human +DTXSID6046713 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046713 Fup 0.729 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046713 Vd NA 0.5026 L/kg 1compartment NA NA Human Human DTXSID6046713 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046713 TK.Half.Life NA 5.023 hours 1compartment NA NA Human Human -DTXSID6046713 Css NA 0.9108 mg/L 3compartmentss NA 50% Human Human -DTXSID6046713 Css NA 4.986 mg/L 3compartmentss NA 95% Human Human -DTXSID6046713 Css NA 0.744 mg/L PBTK NA 50% Human Human -DTXSID6046713 Css NA 3.242 mg/L PBTK NA 95% Human Human -DTXSID6046713 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046713 Fup NA 0.9501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046713 Vd NA 0.7579 L/kg 1compartment NA NA Rat Human +DTXSID6046713 TK.Half.Life NA 4.46 hours 1compartment NA NA Human Human +DTXSID6046713 Css NA 1.103 mg/L 3compartmentss NA 50% Human Human +DTXSID6046713 Css NA 6.825 mg/L 3compartmentss NA 95% Human Human +DTXSID6046713 Css NA 0.8343 mg/L PBTK NA 50% Human Human +DTXSID6046713 Css NA 4.263 mg/L PBTK NA 95% Human Human +DTXSID6046713 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046713 Fup 0.729 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046713 Vd NA 0.5163 L/kg 1compartment NA NA Rat Human DTXSID6046713 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046713 TK.Half.Life NA 1.76 hours 1compartment NA NA Rat Human -DTXSID6046713 Css NA 0.2328 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046713 Css NA 1.291 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046713 Css NA 0.1842 mg/L PBTK NA 50% Rat Human -DTXSID6046713 Css NA 0.7742 mg/L PBTK NA 95% Rat Human -DTXSID6046715 Clint NA 0.7257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046715 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046715 Vd NA 2.299 L/kg 1compartment NA NA Human Human -DTXSID6046715 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046715 TK.Half.Life NA 7.057 hours 1compartment NA NA Human Human -DTXSID6046715 Css NA 0.2994 mg/L 3compartmentss NA 50% Human Human -DTXSID6046715 Css NA 2.227 mg/L 3compartmentss NA 95% Human Human -DTXSID6046715 Css NA 0.3202 mg/L PBTK NA 50% Human Human -DTXSID6046715 Css NA 1.665 mg/L PBTK NA 95% Human Human -DTXSID6046715 Clint NA 0.7257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046715 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046715 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID6046713 TK.Half.Life NA 1.561 hours 1compartment NA NA Rat Human +DTXSID6046713 Css NA 0.06516 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046713 Css NA 0.3935 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046713 Css NA 0.04924 mg/L PBTK NA 50% Rat Human +DTXSID6046713 Css NA 0.2364 mg/L PBTK NA 95% Rat Human +DTXSID6046715 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046715 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046715 Vd NA 1.915 L/kg 1compartment NA NA Human Human +DTXSID6046715 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6046715 TK.Half.Life NA 15.8 hours 1compartment NA NA Human Human +DTXSID6046715 Css NA 0.7939 mg/L 3compartmentss NA 50% Human Human +DTXSID6046715 Css NA 5.687 mg/L 3compartmentss NA 95% Human Human +DTXSID6046715 Css NA 0.7994 mg/L PBTK NA 50% Human Human +DTXSID6046715 Css NA 3.899 mg/L PBTK NA 95% Human Human +DTXSID6046715 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046715 Fup 0.784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046715 Vd NA 1.947 L/kg 1compartment NA NA Rat Human DTXSID6046715 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046715 TK.Half.Life NA 3.323 hours 1compartment NA NA Rat Human -DTXSID6046715 Css NA 0.1032 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046715 Css NA 0.7685 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046715 Css NA 0.1115 mg/L PBTK NA 50% Rat Human -DTXSID6046715 Css NA 0.5074 mg/L PBTK NA 95% Rat Human +DTXSID6046715 TK.Half.Life NA 5.475 hours 1compartment NA NA Rat Human +DTXSID6046715 Css NA 0.04638 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046715 Css NA 0.3149 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046715 Css NA 0.04764 mg/L PBTK NA 50% Rat Human +DTXSID6046715 Css NA 0.2098 mg/L PBTK NA 95% Rat Human DTXSID6046719 Clint NA 4.622 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6046719 Fup NA 0.3791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046719 Vd NA 3.04 L/kg 1compartment NA NA Human Human -DTXSID6046719 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID6046719 TK.Half.Life NA 51.54 hours 1compartment NA NA Human Human -DTXSID6046719 Css NA 1.946 mg/L 3compartmentss NA 50% Human Human -DTXSID6046719 Css NA 9.481 mg/L 3compartmentss NA 95% Human Human -DTXSID6046719 Css NA 1.413 mg/L PBTK NA 50% Human Human -DTXSID6046719 Css NA 6.539 mg/L PBTK NA 95% Human Human +DTXSID6046719 Vd NA 2.603 L/kg 1compartment NA NA Human Human +DTXSID6046719 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6046719 TK.Half.Life NA 14.56 hours 1compartment NA NA Human Human +DTXSID6046719 Css NA 0.4822 mg/L 3compartmentss NA 50% Human Human +DTXSID6046719 Css NA 2.572 mg/L 3compartmentss NA 95% Human Human +DTXSID6046719 Css NA 0.3712 mg/L PBTK NA 50% Human Human +DTXSID6046719 Css NA 1.839 mg/L PBTK NA 95% Human Human DTXSID6046719 Clint NA 4.622 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6046719 Fup NA 0.3791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046719 Vd NA 2.3 L/kg 1compartment NA NA Rat Human -DTXSID6046719 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6046719 TK.Half.Life NA 7.815 hours 1compartment NA NA Rat Human -DTXSID6046719 Css NA 0.9994 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046719 Css NA 3.54 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046719 Css NA 0.6965 mg/L PBTK NA 50% Rat Human -DTXSID6046719 Css NA 2.349 mg/L PBTK NA 95% Rat Human -DTXSID6046761 Clint NA 6.511 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046761 Fup NA 0.3186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046761 Vd NA 2.179 L/kg 1compartment NA NA Human Human +DTXSID6046719 Vd NA 2.008 L/kg 1compartment NA NA Rat Human +DTXSID6046719 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6046719 TK.Half.Life NA 3.546 hours 1compartment NA NA Rat Human +DTXSID6046719 Css NA 0.02179 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046719 Css NA 0.1225 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046719 Css NA 0.0163 mg/L PBTK NA 50% Rat Human +DTXSID6046719 Css NA 0.08703 mg/L PBTK NA 95% Rat Human +DTXSID6046761 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046761 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046761 Vd NA 3.751 L/kg 1compartment NA NA Human Human DTXSID6046761 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046761 TK.Half.Life NA 4.702 hours 1compartment NA NA Human Human -DTXSID6046761 Css NA 0.1557 mg/L 3compartmentss NA 50% Human Human -DTXSID6046761 Css NA 1.095 mg/L 3compartmentss NA 95% Human Human -DTXSID6046761 Css NA 0.1474 mg/L PBTK NA 50% Human Human -DTXSID6046761 Css NA 0.8485 mg/L PBTK NA 95% Human Human -DTXSID6046761 Clint NA 6.511 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046761 Fup NA 0.3186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046761 Vd NA 2.195 L/kg 1compartment NA NA Rat Human +DTXSID6046761 TK.Half.Life NA 4.239 hours 1compartment NA NA Human Human +DTXSID6046761 Css NA 0.06269 mg/L 3compartmentss NA 50% Human Human +DTXSID6046761 Css NA 0.6842 mg/L 3compartmentss NA 95% Human Human +DTXSID6046761 Css NA 0.07934 mg/L PBTK NA 50% Human Human +DTXSID6046761 Css NA 0.5777 mg/L PBTK NA 95% Human Human +DTXSID6046761 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046761 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046761 Vd NA 3.824 L/kg 1compartment NA NA Rat Human DTXSID6046761 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046761 TK.Half.Life NA 2.751 hours 1compartment NA NA Rat Human -DTXSID6046761 Css NA 0.07722 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046761 Css NA 0.4186 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046761 Css NA 0.07151 mg/L PBTK NA 50% Rat Human -DTXSID6046761 Css NA 0.3107 mg/L PBTK NA 95% Rat Human +DTXSID6046761 TK.Half.Life NA 2.409 hours 1compartment NA NA Rat Human +DTXSID6046761 Css NA 0.006582 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046761 Css NA 0.06915 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046761 Css NA 0.008918 mg/L PBTK NA 50% Rat Human +DTXSID6046761 Css NA 0.05505 mg/L PBTK NA 95% Rat Human DTXSID6046763 Clint 2.492 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID6046763 Fup 0.1 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID6046763 Vd NA 1.135 L/kg 1compartment NA NA Human Human DTXSID6046763 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID6046763 TK.Half.Life NA 16.16 hours 1compartment NA NA Human Human -DTXSID6046763 Css NA 2.23 mg/L 3compartmentss NA 50% Human Human -DTXSID6046763 Css NA 11.93 mg/L 3compartmentss NA 95% Human Human -DTXSID6046763 Css NA 1.385 mg/L PBTK NA 50% Human Human -DTXSID6046763 Css NA 7.162 mg/L PBTK NA 95% Human Human +DTXSID6046763 Css NA 2.173 mg/L 3compartmentss NA 50% Human Human +DTXSID6046763 Css NA 11.71 mg/L 3compartmentss NA 95% Human Human +DTXSID6046763 Css NA 1.346 mg/L PBTK NA 50% Human Human +DTXSID6046763 Css NA 7.262 mg/L PBTK NA 95% Human Human DTXSID6046763 Clint 177.9 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID6046763 Fup 0.28 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID6046763 Vd NA 1.449 L/kg 1compartment NA NA Rat Rat DTXSID6046763 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID6046763 TK.Half.Life NA 0.6205 hours 1compartment NA NA Rat Rat -DTXSID6046763 Css NA 0.00869 mg/L 3compartmentss NA 50% Rat Rat -DTXSID6046763 Css NA 0.04833 mg/L 3compartmentss NA 95% Rat Rat -DTXSID6046763 Css NA 0.005046 mg/L PBTK NA 50% Rat Rat -DTXSID6046763 Css NA 0.02712 mg/L PBTK NA 95% Rat Rat -DTXSID6046765 Clint NA 1.109 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046765 Fup NA 0.733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046765 Vd NA 0.9067 L/kg 1compartment NA NA Human Human +DTXSID6046763 Css NA 0.001596 mg/L 3compartmentss NA 50% Rat Rat +DTXSID6046763 Css NA 0.01024 mg/L 3compartmentss NA 95% Rat Rat +DTXSID6046763 Css NA 0.00103 mg/L PBTK NA 50% Rat Rat +DTXSID6046763 Css NA 0.006579 mg/L PBTK NA 95% Rat Rat +DTXSID6046765 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046765 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046765 Vd NA 0.6342 L/kg 1compartment NA NA Human Human DTXSID6046765 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046765 TK.Half.Life NA 3.128 hours 1compartment NA NA Human Human -DTXSID6046765 Css NA 0.3787 mg/L 3compartmentss NA 50% Human Human -DTXSID6046765 Css NA 2.506 mg/L 3compartmentss NA 95% Human Human -DTXSID6046765 Css NA 0.31 mg/L PBTK NA 50% Human Human -DTXSID6046765 Css NA 1.626 mg/L PBTK NA 95% Human Human -DTXSID6046765 Clint NA 1.109 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046765 Fup NA 0.733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046765 Vd NA 0.8561 L/kg 1compartment NA NA Rat Human +DTXSID6046765 TK.Half.Life NA 1.316 hours 1compartment NA NA Human Human +DTXSID6046765 Css NA 0.167 mg/L 3compartmentss NA 50% Human Human +DTXSID6046765 Css NA 1.113 mg/L 3compartmentss NA 95% Human Human +DTXSID6046765 Css NA 0.1215 mg/L PBTK NA 50% Human Human +DTXSID6046765 Css NA 0.7333 mg/L PBTK NA 95% Human Human +DTXSID6046765 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046765 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046765 Vd NA 0.5966 L/kg 1compartment NA NA Rat Human DTXSID6046765 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046765 TK.Half.Life NA 1.417 hours 1compartment NA NA Rat Human -DTXSID6046765 Css NA 0.146 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046765 Css NA 0.9646 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046765 Css NA 0.1182 mg/L PBTK NA 50% Rat Human -DTXSID6046765 Css NA 0.5782 mg/L PBTK NA 95% Rat Human -DTXSID6046767 Clint NA 15.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046767 Fup NA 0.3305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046767 Vd NA 0.6026 L/kg 1compartment NA NA Human Human +DTXSID6046765 TK.Half.Life NA 0.6856 hours 1compartment NA NA Rat Human +DTXSID6046765 Css NA 0.01948 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046765 Css NA 0.09737 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046765 Css NA 0.01415 mg/L PBTK NA 50% Rat Human +DTXSID6046765 Css NA 0.06218 mg/L PBTK NA 95% Rat Human +DTXSID6046767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046767 Fup 0.765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046767 Vd NA 0.9196 L/kg 1compartment NA NA Human Human DTXSID6046767 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046767 TK.Half.Life NA 0.8598 hours 1compartment NA NA Human Human -DTXSID6046767 Css NA 0.08816 mg/L 3compartmentss NA 50% Human Human -DTXSID6046767 Css NA 0.6242 mg/L 3compartmentss NA 95% Human Human -DTXSID6046767 Css NA 0.06367 mg/L PBTK NA 50% Human Human -DTXSID6046767 Css NA 0.4131 mg/L PBTK NA 95% Human Human -DTXSID6046767 Clint NA 15.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046767 Fup NA 0.3305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046767 Vd NA 0.5815 L/kg 1compartment NA NA Rat Human +DTXSID6046767 TK.Half.Life NA 7.9 hours 1compartment NA NA Human Human +DTXSID6046767 Css NA 0.969 mg/L 3compartmentss NA 50% Human Human +DTXSID6046767 Css NA 6.192 mg/L 3compartmentss NA 95% Human Human +DTXSID6046767 Css NA 0.8252 mg/L PBTK NA 50% Human Human +DTXSID6046767 Css NA 3.983 mg/L PBTK NA 95% Human Human +DTXSID6046767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046767 Fup 0.765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046767 Vd NA 0.9057 L/kg 1compartment NA NA Rat Human DTXSID6046767 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046767 TK.Half.Life NA 0.4469 hours 1compartment NA NA Rat Human -DTXSID6046767 Css NA 0.04664 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046767 Css NA 0.2599 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046767 Css NA 0.03222 mg/L PBTK NA 50% Rat Human -DTXSID6046767 Css NA 0.1636 mg/L PBTK NA 95% Rat Human -DTXSID6046842 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6046767 TK.Half.Life NA 2.621 hours 1compartment NA NA Rat Human +DTXSID6046767 Css NA 0.05662 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046767 Css NA 0.3614 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046767 Css NA 0.04882 mg/L PBTK NA 50% Rat Human +DTXSID6046767 Css NA 0.2259 mg/L PBTK NA 95% Rat Human +DTXSID6046842 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6046842 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6046842 Vd NA 0.7123 L/kg 1compartment NA NA Human Human +DTXSID6046842 Vd NA 0.701 L/kg 1compartment NA NA Human Human DTXSID6046842 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046842 TK.Half.Life NA 5.767 hours 1compartment NA NA Human Human -DTXSID6046842 Css NA 0.9965 mg/L 3compartmentss NA 50% Human Human -DTXSID6046842 Css NA 5.981 mg/L 3compartmentss NA 95% Human Human -DTXSID6046842 Css NA 0.8142 mg/L PBTK NA 50% Human Human -DTXSID6046842 Css NA 3.83 mg/L PBTK NA 95% Human Human -DTXSID6046842 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6046842 TK.Half.Life NA 5.672 hours 1compartment NA NA Human Human +DTXSID6046842 Css NA 0.5448 mg/L 3compartmentss NA 50% Human Human +DTXSID6046842 Css NA 3.298 mg/L 3compartmentss NA 95% Human Human +DTXSID6046842 Css NA 0.4477 mg/L PBTK NA 50% Human Human +DTXSID6046842 Css NA 2.129 mg/L PBTK NA 95% Human Human +DTXSID6046842 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6046842 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6046842 Vd NA 0.7417 L/kg 1compartment NA NA Rat Human +DTXSID6046842 Vd NA 0.7319 L/kg 1compartment NA NA Rat Human DTXSID6046842 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046842 TK.Half.Life NA 2.045 hours 1compartment NA NA Rat Human -DTXSID6046842 Css NA 0.2574 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046842 Css NA 1.478 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046842 Css NA 0.2033 mg/L PBTK NA 50% Rat Human -DTXSID6046842 Css NA 0.8831 mg/L PBTK NA 95% Rat Human -DTXSID6046844 Clint NA 84.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046844 Fup NA 0.0163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046844 Vd NA 5.75 L/kg 1compartment NA NA Human Human -DTXSID6046844 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID6046844 TK.Half.Life NA 46.65 hours 1compartment NA NA Human Human -DTXSID6046844 Css NA 0.7358 mg/L 3compartmentss NA 50% Human Human -DTXSID6046844 Css NA 4.324 mg/L 3compartmentss NA 95% Human Human -DTXSID6046844 Css NA 0.6284 mg/L PBTK NA 50% Human Human -DTXSID6046844 Css NA 3.503 mg/L PBTK NA 95% Human Human -DTXSID6046844 Clint NA 84.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046844 Fup NA 0.0163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046844 Vd NA 4.419 L/kg 1compartment NA NA Rat Human -DTXSID6046844 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6046844 TK.Half.Life NA 6.95 hours 1compartment NA NA Rat Human -DTXSID6046844 Css NA 0.4058 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046844 Css NA 1.762 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046844 Css NA 0.3408 mg/L PBTK NA 50% Rat Human -DTXSID6046844 Css NA 1.492 mg/L PBTK NA 95% Rat Human -DTXSID6046846 Clint NA 80.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046846 Fup NA 0.1139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046846 Vd NA 1.214 L/kg 1compartment NA NA Human Human +DTXSID6046842 TK.Half.Life NA 2.017 hours 1compartment NA NA Rat Human +DTXSID6046842 Css NA 0.002816 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046842 Css NA 0.01806 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046842 Css NA 0.002235 mg/L PBTK NA 50% Rat Human +DTXSID6046842 Css NA 0.01123 mg/L PBTK NA 95% Rat Human +DTXSID6046844 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046844 Fup 0.0101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046844 Vd NA 14 L/kg 1compartment NA NA Human Human +DTXSID6046844 Days.Css NA 90 Days PBTK NA NA Human Human +DTXSID6046844 TK.Half.Life NA 414.6 hours 1compartment NA NA Human Human +DTXSID6046844 Css NA 1.572 mg/L 3compartmentss NA 50% Human Human +DTXSID6046844 Css NA 9.879 mg/L 3compartmentss NA 95% Human Human +DTXSID6046844 Css NA 2.402 mg/L PBTK NA 50% Human Human +DTXSID6046844 Css NA 14.03 mg/L PBTK NA 95% Human Human +DTXSID6046844 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046844 Fup 0.0101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046844 Vd NA 11.18 L/kg 1compartment NA NA Rat Human +DTXSID6046844 Days.Css NA 55 Days PBTK NA NA Rat Human +DTXSID6046844 TK.Half.Life NA 59.04 hours 1compartment NA NA Rat Human +DTXSID6046844 Css NA 0.1957 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046844 Css NA 0.9364 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046844 Css NA 0.3161 mg/L PBTK NA 50% Rat Human +DTXSID6046844 Css NA 1.553 mg/L PBTK NA 95% Rat Human +DTXSID6046846 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046846 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046846 Vd NA 2.916 L/kg 1compartment NA NA Human Human DTXSID6046846 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046846 TK.Half.Life NA 1.398 hours 1compartment NA NA Human Human -DTXSID6046846 Css NA 0.06007 mg/L 3compartmentss NA 50% Human Human -DTXSID6046846 Css NA 0.5382 mg/L 3compartmentss NA 95% Human Human -DTXSID6046846 Css NA 0.0426 mg/L PBTK NA 50% Human Human -DTXSID6046846 Css NA 0.35 mg/L PBTK NA 95% Human Human -DTXSID6046846 Clint NA 80.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046846 Fup NA 0.1139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046846 Vd NA 1.202 L/kg 1compartment NA NA Rat Human +DTXSID6046846 TK.Half.Life NA 5.373 hours 1compartment NA NA Human Human +DTXSID6046846 Css NA 0.1118 mg/L 3compartmentss NA 50% Human Human +DTXSID6046846 Css NA 0.8521 mg/L 3compartmentss NA 95% Human Human +DTXSID6046846 Css NA 0.1243 mg/L PBTK NA 50% Human Human +DTXSID6046846 Css NA 0.7096 mg/L PBTK NA 95% Human Human +DTXSID6046846 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046846 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046846 Vd NA 2.952 L/kg 1compartment NA NA Rat Human DTXSID6046846 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046846 TK.Half.Life NA 0.7245 hours 1compartment NA NA Rat Human -DTXSID6046846 Css NA 0.03348 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046846 Css NA 0.2385 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046846 Css NA 0.02265 mg/L PBTK NA 50% Rat Human -DTXSID6046846 Css NA 0.1466 mg/L PBTK NA 95% Rat Human -DTXSID6046890 Clint NA 696.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046890 Fup NA 0.2644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046890 Vd NA 0.5013 L/kg 1compartment NA NA Human Human +DTXSID6046846 TK.Half.Life NA 3.169 hours 1compartment NA NA Rat Human +DTXSID6046846 Css NA 0.01254 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046846 Css NA 0.07489 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046846 Css NA 0.01436 mg/L PBTK NA 50% Rat Human +DTXSID6046846 Css NA 0.06241 mg/L PBTK NA 95% Rat Human +DTXSID6046890 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046890 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046890 Vd NA 0.5163 L/kg 1compartment NA NA Human Human DTXSID6046890 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046890 TK.Half.Life NA 0.4104 hours 1compartment NA NA Human Human -DTXSID6046890 Css NA 0.002731 mg/L 3compartmentss NA 50% Human Human -DTXSID6046890 Css NA 0.02127 mg/L 3compartmentss NA 95% Human Human -DTXSID6046890 Css NA 0.001876 mg/L PBTK NA 50% Human Human -DTXSID6046890 Css NA 0.01365 mg/L PBTK NA 95% Human Human -DTXSID6046890 Clint NA 696.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046890 Fup NA 0.2644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046890 Vd NA 0.4949 L/kg 1compartment NA NA Rat Human +DTXSID6046890 TK.Half.Life NA 1.388 hours 1compartment NA NA Human Human +DTXSID6046890 Css NA 0.2134 mg/L 3compartmentss NA 50% Human Human +DTXSID6046890 Css NA 1.329 mg/L 3compartmentss NA 95% Human Human +DTXSID6046890 Css NA 0.1481 mg/L PBTK NA 50% Human Human +DTXSID6046890 Css NA 0.8606 mg/L PBTK NA 95% Human Human +DTXSID6046890 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046890 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046890 Vd NA 0.5105 L/kg 1compartment NA NA Rat Human DTXSID6046890 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046890 TK.Half.Life NA 0.1786 hours 1compartment NA NA Rat Human -DTXSID6046890 Css NA 0.001508 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046890 Css NA 0.009374 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046890 Css NA 0.0009867 mg/L PBTK NA 50% Rat Human -DTXSID6046890 Css NA 0.00578 mg/L PBTK NA 95% Rat Human -DTXSID6046892 Clint NA 455.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046892 Fup NA 0.0752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046892 Vd NA 1.702 L/kg 1compartment NA NA Human Human +DTXSID6046890 TK.Half.Life NA 0.7867 hours 1compartment NA NA Rat Human +DTXSID6046890 Css NA 0.009415 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046890 Css NA 0.06739 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046890 Css NA 0.006468 mg/L PBTK NA 50% Rat Human +DTXSID6046890 Css NA 0.0423 mg/L PBTK NA 95% Rat Human +DTXSID6046892 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046892 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046892 Vd NA 1.263 L/kg 1compartment NA NA Human Human DTXSID6046892 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046892 TK.Half.Life NA 1.68 hours 1compartment NA NA Human Human -DTXSID6046892 Css NA 0.02223 mg/L 3compartmentss NA 50% Human Human -DTXSID6046892 Css NA 0.1721 mg/L 3compartmentss NA 95% Human Human -DTXSID6046892 Css NA 0.01459 mg/L PBTK NA 50% Human Human -DTXSID6046892 Css NA 0.107 mg/L PBTK NA 95% Human Human -DTXSID6046892 Clint NA 455.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046892 Fup NA 0.0752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046892 Vd NA 1.284 L/kg 1compartment NA NA Rat Human +DTXSID6046892 TK.Half.Life NA 3.248 hours 1compartment NA NA Human Human +DTXSID6046892 Css NA 0.2342 mg/L 3compartmentss NA 50% Human Human +DTXSID6046892 Css NA 1.919 mg/L 3compartmentss NA 95% Human Human +DTXSID6046892 Css NA 0.1545 mg/L PBTK NA 50% Human Human +DTXSID6046892 Css NA 1.183 mg/L PBTK NA 95% Human Human +DTXSID6046892 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046892 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046892 Vd NA 0.976 L/kg 1compartment NA NA Rat Human DTXSID6046892 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046892 TK.Half.Life NA 0.5654 hours 1compartment NA NA Rat Human -DTXSID6046892 Css NA 0.0127 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046892 Css NA 0.07901 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046892 Css NA 0.007888 mg/L PBTK NA 50% Rat Human -DTXSID6046892 Css NA 0.04643 mg/L PBTK NA 95% Rat Human -DTXSID6046894 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046894 Fup NA 0.1431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046894 Vd NA 0.6936 L/kg 1compartment NA NA Human Human -DTXSID6046894 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID6046894 TK.Half.Life NA 31.64 hours 1compartment NA NA Human Human -DTXSID6046894 Css NA 6.47 mg/L 3compartmentss NA 50% Human Human -DTXSID6046894 Css NA 29.71 mg/L 3compartmentss NA 95% Human Human -DTXSID6046894 Css NA 4.265 mg/L PBTK NA 50% Human Human -DTXSID6046894 Css NA 17.7 mg/L PBTK NA 95% Human Human -DTXSID6046894 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046894 Fup NA 0.1431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046894 Vd NA 0.6701 L/kg 1compartment NA NA Rat Human -DTXSID6046894 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6046894 TK.Half.Life NA 10.35 hours 1compartment NA NA Rat Human -DTXSID6046894 Css NA 1.787 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046894 Css NA 7.064 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046894 Css NA 1.108 mg/L PBTK NA 50% Rat Human -DTXSID6046894 Css NA 3.973 mg/L PBTK NA 95% Rat Human -DTXSID6046896 Clint NA 45.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046896 Fup NA 0.0884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046896 Vd NA 1.186 L/kg 1compartment NA NA Human Human +DTXSID6046892 TK.Half.Life NA 1.327 hours 1compartment NA NA Rat Human +DTXSID6046892 Css NA 0.01134 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046892 Css NA 0.1003 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046892 Css NA 0.007262 mg/L PBTK NA 50% Rat Human +DTXSID6046892 Css NA 0.06028 mg/L PBTK NA 95% Rat Human +DTXSID6046896 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046896 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046896 Vd NA 0.3675 L/kg 1compartment NA NA Human Human DTXSID6046896 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046896 TK.Half.Life NA 2.196 hours 1compartment NA NA Human Human -DTXSID6046896 Css NA 0.1669 mg/L 3compartmentss NA 50% Human Human -DTXSID6046896 Css NA 1.383 mg/L 3compartmentss NA 95% Human Human -DTXSID6046896 Css NA 0.1078 mg/L PBTK NA 50% Human Human -DTXSID6046896 Css NA 0.8456 mg/L PBTK NA 95% Human Human -DTXSID6046896 Clint NA 45.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046896 Fup NA 0.0884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046896 Vd NA 0.9162 L/kg 1compartment NA NA Rat Human +DTXSID6046896 TK.Half.Life NA 9.253 hours 1compartment NA NA Human Human +DTXSID6046896 Css NA 2.974 mg/L 3compartmentss NA 50% Human Human +DTXSID6046896 Css NA 11.04 mg/L 3compartmentss NA 95% Human Human +DTXSID6046896 Css NA 1.996 mg/L PBTK NA 50% Human Human +DTXSID6046896 Css NA 6.901 mg/L PBTK NA 95% Human Human +DTXSID6046896 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046896 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046896 Vd NA 0.3772 L/kg 1compartment NA NA Rat Human DTXSID6046896 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046896 TK.Half.Life NA 0.8833 hours 1compartment NA NA Rat Human -DTXSID6046896 Css NA 0.09421 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046896 Css NA 0.5564 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046896 Css NA 0.0572 mg/L PBTK NA 50% Rat Human -DTXSID6046896 Css NA 0.3262 mg/L PBTK NA 95% Rat Human -DTXSID6046898 Clint NA 64.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046898 Fup NA 0.0437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046898 Vd NA 0.3144 L/kg 1compartment NA NA Human Human +DTXSID6046896 TK.Half.Life NA 3.236 hours 1compartment NA NA Rat Human +DTXSID6046896 Css NA 0.1921 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046896 Css NA 0.6155 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046896 Css NA 0.1263 mg/L PBTK NA 50% Rat Human +DTXSID6046896 Css NA 0.3653 mg/L PBTK NA 95% Rat Human +DTXSID6046898 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046898 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046898 Vd NA 0.4821 L/kg 1compartment NA NA Human Human DTXSID6046898 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046898 TK.Half.Life NA 0.7133 hours 1compartment NA NA Human Human -DTXSID6046898 Css NA 0.2456 mg/L 3compartmentss NA 50% Human Human -DTXSID6046898 Css NA 2.309 mg/L 3compartmentss NA 95% Human Human -DTXSID6046898 Css NA 0.1479 mg/L PBTK NA 50% Human Human -DTXSID6046898 Css NA 1.356 mg/L PBTK NA 95% Human Human -DTXSID6046898 Clint NA 64.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046898 Fup NA 0.0437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046898 Vd NA 0.2807 L/kg 1compartment NA NA Rat Human +DTXSID6046898 TK.Half.Life NA 2.726 hours 1compartment NA NA Human Human +DTXSID6046898 Css NA 0.682 mg/L 3compartmentss NA 50% Human Human +DTXSID6046898 Css NA 4.881 mg/L 3compartmentss NA 95% Human Human +DTXSID6046898 Css NA 0.4316 mg/L PBTK NA 50% Human Human +DTXSID6046898 Css NA 2.935 mg/L PBTK NA 95% Human Human +DTXSID6046898 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046898 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046898 Vd NA 0.4262 L/kg 1compartment NA NA Rat Human DTXSID6046898 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046898 TK.Half.Life NA 0.3719 hours 1compartment NA NA Rat Human -DTXSID6046898 Css NA 0.1443 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046898 Css NA 1.059 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046898 Css NA 0.0808 mg/L PBTK NA 50% Rat Human -DTXSID6046898 Css NA 0.5832 mg/L PBTK NA 95% Rat Human -DTXSID6046925 Clint NA 43.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046925 Fup NA 0.7848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046925 Vd NA 3.179 L/kg 1compartment NA NA Human Human -DTXSID6046925 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6046925 TK.Half.Life NA 20.31 hours 1compartment NA NA Human Human -DTXSID6046925 Css NA 0.6838 mg/L 3compartmentss NA 50% Human Human -DTXSID6046925 Css NA 4.531 mg/L 3compartmentss NA 95% Human Human -DTXSID6046925 Css NA 0.4806 mg/L PBTK NA 50% Human Human -DTXSID6046925 Css NA 3.101 mg/L PBTK NA 95% Human Human -DTXSID6046925 Clint NA 43.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046925 Fup NA 0.7848 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046925 Vd NA 2.398 L/kg 1compartment NA NA Rat Human -DTXSID6046925 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6046925 TK.Half.Life NA 3.094 hours 1compartment NA NA Rat Human -DTXSID6046925 Css NA 0.3813 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046925 Css NA 2.089 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046925 Css NA 0.2572 mg/L PBTK NA 50% Rat Human -DTXSID6046925 Css NA 1.391 mg/L PBTK NA 95% Rat Human -DTXSID6046977 Clint NA 20.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046977 Fup NA 0.3931 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046977 Vd NA 4.42 L/kg 1compartment NA NA Human Human +DTXSID6046898 TK.Half.Life NA 1.445 hours 1compartment NA NA Rat Human +DTXSID6046898 Css NA 0.03101 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046898 Css NA 0.2523 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046898 Css NA 0.01893 mg/L PBTK NA 50% Rat Human +DTXSID6046898 Css NA 0.146 mg/L PBTK NA 95% Rat Human +DTXSID6046925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046925 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046925 Vd NA 0.8139 L/kg 1compartment NA NA Human Human +DTXSID6046925 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6046925 TK.Half.Life NA 1.698 hours 1compartment NA NA Human Human +DTXSID6046925 Css NA 0.1912 mg/L 3compartmentss NA 50% Human Human +DTXSID6046925 Css NA 1.6 mg/L 3compartmentss NA 95% Human Human +DTXSID6046925 Css NA 0.1279 mg/L PBTK NA 50% Human Human +DTXSID6046925 Css NA 0.9927 mg/L PBTK NA 95% Human Human +DTXSID6046925 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046925 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046925 Vd NA 0.7963 L/kg 1compartment NA NA Rat Human +DTXSID6046925 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6046925 TK.Half.Life NA 0.9643 hours 1compartment NA NA Rat Human +DTXSID6046925 Css NA 0.0252 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046925 Css NA 0.1556 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046925 Css NA 0.01655 mg/L PBTK NA 50% Rat Human +DTXSID6046925 Css NA 0.09434 mg/L PBTK NA 95% Rat Human +DTXSID6046977 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046977 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046977 Vd NA 3.417 L/kg 1compartment NA NA Human Human DTXSID6046977 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6046977 TK.Half.Life NA 3.464 hours 1compartment NA NA Human Human -DTXSID6046977 Css NA 0.02742 mg/L 3compartmentss NA 50% Human Human -DTXSID6046977 Css NA 0.2544 mg/L 3compartmentss NA 95% Human Human -DTXSID6046977 Css NA 0.03761 mg/L PBTK NA 50% Human Human -DTXSID6046977 Css NA 0.2634 mg/L PBTK NA 95% Human Human -DTXSID6046977 Clint NA 20.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046977 Fup NA 0.3931 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046977 Vd NA 4.495 L/kg 1compartment NA NA Rat Human +DTXSID6046977 TK.Half.Life NA 7.773 hours 1compartment NA NA Human Human +DTXSID6046977 Css NA 0.1398 mg/L 3compartmentss NA 50% Human Human +DTXSID6046977 Css NA 1.016 mg/L 3compartmentss NA 95% Human Human +DTXSID6046977 Css NA 0.1586 mg/L PBTK NA 50% Human Human +DTXSID6046977 Css NA 0.9081 mg/L PBTK NA 95% Human Human +DTXSID6046977 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046977 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046977 Vd NA 3.45 L/kg 1compartment NA NA Rat Human DTXSID6046977 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6046977 TK.Half.Life NA 1.913 hours 1compartment NA NA Rat Human -DTXSID6046977 Css NA 0.01416 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046977 Css NA 0.1114 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046977 Css NA 0.01968 mg/L PBTK NA 50% Rat Human -DTXSID6046977 Css NA 0.1063 mg/L PBTK NA 95% Rat Human -DTXSID6046979 Clint NA 13.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046979 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6046979 Vd NA 3.003 L/kg 1compartment NA NA Human Human -DTXSID6046979 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID6046979 TK.Half.Life NA 91.82 hours 1compartment NA NA Human Human -DTXSID6046979 Css NA 3.955 mg/L 3compartmentss NA 50% Human Human -DTXSID6046979 Css NA 24.33 mg/L 3compartmentss NA 95% Human Human -DTXSID6046979 Css NA 2.714 mg/L PBTK NA 50% Human Human -DTXSID6046979 Css NA 16.26 mg/L PBTK NA 95% Human Human -DTXSID6046979 Clint NA 13.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046979 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6046979 Vd NA 2.248 L/kg 1compartment NA NA Rat Human -DTXSID6046979 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID6046979 TK.Half.Life NA 14.27 hours 1compartment NA NA Rat Human -DTXSID6046979 Css NA 2.197 mg/L 3compartmentss NA 50% Rat Human -DTXSID6046979 Css NA 11.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID6046979 Css NA 1.438 mg/L PBTK NA 50% Rat Human -DTXSID6046979 Css NA 7.311 mg/L PBTK NA 95% Rat Human +DTXSID6046977 TK.Half.Life NA 4.593 hours 1compartment NA NA Rat Human +DTXSID6046977 Css NA 0.01601 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046977 Css NA 0.09042 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046977 Css NA 0.01888 mg/L PBTK NA 50% Rat Human +DTXSID6046977 Css NA 0.07654 mg/L PBTK NA 95% Rat Human +DTXSID6046979 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046979 Fup 0.00987 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6046979 Vd NA 2.781 L/kg 1compartment NA NA Human Human +DTXSID6046979 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID6046979 TK.Half.Life NA 56.58 hours 1compartment NA NA Human Human +DTXSID6046979 Css NA 2.706 mg/L 3compartmentss NA 50% Human Human +DTXSID6046979 Css NA 18.92 mg/L 3compartmentss NA 95% Human Human +DTXSID6046979 Css NA 1.818 mg/L PBTK NA 50% Human Human +DTXSID6046979 Css NA 12.34 mg/L PBTK NA 95% Human Human +DTXSID6046979 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046979 Fup 0.00987 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6046979 Vd NA 2.076 L/kg 1compartment NA NA Rat Human +DTXSID6046979 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID6046979 TK.Half.Life NA 11.16 hours 1compartment NA NA Rat Human +DTXSID6046979 Css NA 0.3516 mg/L 3compartmentss NA 50% Rat Human +DTXSID6046979 Css NA 2.101 mg/L 3compartmentss NA 95% Rat Human +DTXSID6046979 Css NA 0.2318 mg/L PBTK NA 50% Rat Human +DTXSID6046979 Css NA 1.369 mg/L PBTK NA 95% Rat Human DTXSID6047028 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6047028 Fup NA 0.8952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047028 Vd NA 0.6415 L/kg 1compartment NA NA Human Human +DTXSID6047028 Vd NA 0.6446 L/kg 1compartment NA NA Human Human DTXSID6047028 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047028 TK.Half.Life NA 4.636 hours 1compartment NA NA Human Human -DTXSID6047028 Css NA 0.9135 mg/L 3compartmentss NA 50% Human Human -DTXSID6047028 Css NA 3.501 mg/L 3compartmentss NA 95% Human Human -DTXSID6047028 Css NA 0.736 mg/L PBTK NA 50% Human Human -DTXSID6047028 Css NA 2.4 mg/L PBTK NA 95% Human Human +DTXSID6047028 TK.Half.Life NA 4.658 hours 1compartment NA NA Human Human +DTXSID6047028 Css NA 0.7806 mg/L 3compartmentss NA 50% Human Human +DTXSID6047028 Css NA 3.023 mg/L 3compartmentss NA 95% Human Human +DTXSID6047028 Css NA 0.6315 mg/L PBTK NA 50% Human Human +DTXSID6047028 Css NA 2.079 mg/L PBTK NA 95% Human Human DTXSID6047028 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6047028 Fup NA 0.8952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047028 Vd NA 0.6916 L/kg 1compartment NA NA Rat Human +DTXSID6047028 Vd NA 0.6941 L/kg 1compartment NA NA Rat Human DTXSID6047028 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047028 TK.Half.Life NA 1.703 hours 1compartment NA NA Rat Human -DTXSID6047028 Css NA 0.237 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047028 Css NA 0.8451 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047028 Css NA 0.1858 mg/L PBTK NA 50% Rat Human -DTXSID6047028 Css NA 0.5289 mg/L PBTK NA 95% Rat Human -DTXSID6047070 Clint NA 0.01529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047070 Fup NA 0.5868 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047070 Vd NA 1.171 L/kg 1compartment NA NA Human Human -DTXSID6047070 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6047070 TK.Half.Life NA 13.61 hours 1compartment NA NA Human Human -DTXSID6047070 Css NA 1.204 mg/L 3compartmentss NA 50% Human Human -DTXSID6047070 Css NA 7.982 mg/L 3compartmentss NA 95% Human Human -DTXSID6047070 Css NA 1.025 mg/L PBTK NA 50% Human Human -DTXSID6047070 Css NA 5.19 mg/L PBTK NA 95% Human Human -DTXSID6047070 Clint NA 0.01529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047070 Fup NA 0.5868 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047070 Vd NA 1.057 L/kg 1compartment NA NA Rat Human +DTXSID6047028 TK.Half.Life NA 1.71 hours 1compartment NA NA Rat Human +DTXSID6047028 Css NA 0.01416 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047028 Css NA 0.07568 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047028 Css NA 0.011 mg/L PBTK NA 50% Rat Human +DTXSID6047028 Css NA 0.05297 mg/L PBTK NA 95% Rat Human +DTXSID6047070 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047070 Fup 0.535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047070 Vd NA 1.11 L/kg 1compartment NA NA Human Human +DTXSID6047070 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047070 TK.Half.Life NA 1.05 hours 1compartment NA NA Human Human +DTXSID6047070 Css NA 0.03592 mg/L 3compartmentss NA 50% Human Human +DTXSID6047070 Css NA 0.3617 mg/L 3compartmentss NA 95% Human Human +DTXSID6047070 Css NA 0.02947 mg/L PBTK NA 50% Human Human +DTXSID6047070 Css NA 0.2527 mg/L PBTK NA 95% Human Human +DTXSID6047070 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047070 Fup 0.535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047070 Vd NA 1.001 L/kg 1compartment NA NA Rat Human DTXSID6047070 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047070 TK.Half.Life NA 4 hours 1compartment NA NA Rat Human -DTXSID6047070 Css NA 0.326 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047070 Css NA 2.095 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047070 Css NA 0.2678 mg/L PBTK NA 50% Rat Human -DTXSID6047070 Css NA 1.257 mg/L PBTK NA 95% Rat Human -DTXSID6047072 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047072 Fup NA 0.357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047072 Vd NA 2.608 L/kg 1compartment NA NA Human Human +DTXSID6047070 TK.Half.Life NA 0.4687 hours 1compartment NA NA Rat Human +DTXSID6047070 Css NA 0.00442 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047070 Css NA 0.03543 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047070 Css NA 0.003696 mg/L PBTK NA 50% Rat Human +DTXSID6047070 Css NA 0.02443 mg/L PBTK NA 95% Rat Human +DTXSID6047072 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047072 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047072 Vd NA 1.973 L/kg 1compartment NA NA Human Human DTXSID6047072 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047072 TK.Half.Life NA 13.15 hours 1compartment NA NA Human Human -DTXSID6047072 Css NA 0.5085 mg/L 3compartmentss NA 50% Human Human -DTXSID6047072 Css NA 2.718 mg/L 3compartmentss NA 95% Human Human -DTXSID6047072 Css NA 0.3872 mg/L PBTK NA 50% Human Human -DTXSID6047072 Css NA 1.941 mg/L PBTK NA 95% Human Human -DTXSID6047072 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047072 Fup NA 0.357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047072 Vd NA 2.008 L/kg 1compartment NA NA Rat Human +DTXSID6047072 TK.Half.Life NA 3.551 hours 1compartment NA NA Human Human +DTXSID6047072 Css NA 0.1258 mg/L 3compartmentss NA 50% Human Human +DTXSID6047072 Css NA 0.834 mg/L 3compartmentss NA 95% Human Human +DTXSID6047072 Css NA 0.09284 mg/L PBTK NA 50% Human Human +DTXSID6047072 Css NA 0.5823 mg/L PBTK NA 95% Human Human +DTXSID6047072 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047072 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047072 Vd NA 1.533 L/kg 1compartment NA NA Rat Human DTXSID6047072 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047072 TK.Half.Life NA 3.237 hours 1compartment NA NA Rat Human -DTXSID6047072 Css NA 0.2606 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047072 Css NA 0.9658 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047072 Css NA 0.1921 mg/L PBTK NA 50% Rat Human -DTXSID6047072 Css NA 0.6497 mg/L PBTK NA 95% Rat Human -DTXSID6047076 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047076 Fup NA 0.2924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047076 Vd NA 7726 L/kg 1compartment NA NA Human Human -DTXSID6047076 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6047076 TK.Half.Life NA 346600000 hours 1compartment NA NA Human Human -DTXSID6047076 Css NA 2.498 mg/L 3compartmentss NA 50% Human Human -DTXSID6047076 Css NA 6.827 mg/L 3compartmentss NA 95% Human Human -DTXSID6047076 Css NA 3613 mg/L PBTK NA 50% Human Human -DTXSID6047076 Css NA 7844 mg/L PBTK NA 95% Human Human -DTXSID6047076 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047076 Fup NA 0.2924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047076 Vd NA 7255 L/kg 1compartment NA NA Rat Human -DTXSID6047076 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6047076 TK.Half.Life NA 27730000 hours 1compartment NA NA Rat Human -DTXSID6047076 Css NA 0.6056 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047076 Css NA 1.142 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047076 Css NA 965.3 mg/L PBTK NA 50% Rat Human -DTXSID6047076 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID6047101 Clint NA 0.6429 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047101 Fup NA 0.5214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047101 Vd NA 1.271 L/kg 1compartment NA NA Human Human +DTXSID6047072 TK.Half.Life NA 1.232 hours 1compartment NA NA Rat Human +DTXSID6047072 Css NA 0.01565 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047072 Css NA 0.08372 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047072 Css NA 0.01148 mg/L PBTK NA 50% Rat Human +DTXSID6047072 Css NA 0.0581 mg/L PBTK NA 95% Rat Human +DTXSID6047101 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047101 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047101 Vd NA 1.277 L/kg 1compartment NA NA Human Human DTXSID6047101 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047101 TK.Half.Life NA 8.637 hours 1compartment NA NA Human Human -DTXSID6047101 Css NA 0.6677 mg/L 3compartmentss NA 50% Human Human -DTXSID6047101 Css NA 3.864 mg/L 3compartmentss NA 95% Human Human -DTXSID6047101 Css NA 0.5632 mg/L PBTK NA 50% Human Human -DTXSID6047101 Css NA 2.573 mg/L PBTK NA 95% Human Human -DTXSID6047101 Clint NA 0.6429 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047101 Fup NA 0.5214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047101 Vd NA 1.112 L/kg 1compartment NA NA Rat Human +DTXSID6047101 TK.Half.Life NA 1.228 hours 1compartment NA NA Human Human +DTXSID6047101 Css NA 0.03746 mg/L 3compartmentss NA 50% Human Human +DTXSID6047101 Css NA 0.3533 mg/L 3compartmentss NA 95% Human Human +DTXSID6047101 Css NA 0.03108 mg/L PBTK NA 50% Human Human +DTXSID6047101 Css NA 0.2554 mg/L PBTK NA 95% Human Human +DTXSID6047101 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047101 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047101 Vd NA 1.117 L/kg 1compartment NA NA Rat Human DTXSID6047101 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047101 TK.Half.Life NA 3.188 hours 1compartment NA NA Rat Human -DTXSID6047101 Css NA 0.2478 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047101 Css NA 1.299 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047101 Css NA 0.2017 mg/L PBTK NA 50% Rat Human -DTXSID6047101 Css NA 0.7995 mg/L PBTK NA 95% Rat Human -DTXSID6047103 Clint NA 2.899 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047103 Fup NA 0.0069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047103 Vd NA 5.565 L/kg 1compartment NA NA Human Human -DTXSID6047103 Days.Css NA 184 Days PBTK NA NA Human Human -DTXSID6047103 TK.Half.Life NA 755.7 hours 1compartment NA NA Human Human -DTXSID6047103 Css NA 16.88 mg/L 3compartmentss NA 50% Human Human -DTXSID6047103 Css NA 114.7 mg/L 3compartmentss NA 95% Human Human -DTXSID6047103 Css NA 14.08 mg/L PBTK NA 50% Human Human -DTXSID6047103 Css NA 83.49 mg/L PBTK NA 95% Human Human -DTXSID6047103 Clint NA 2.899 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047103 Fup NA 0.0069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047103 Vd NA 4.274 L/kg 1compartment NA NA Rat Human -DTXSID6047103 Days.Css NA 97 Days PBTK NA NA Rat Human -DTXSID6047103 TK.Half.Life NA 206.2 hours 1compartment NA NA Rat Human -DTXSID6047103 Css NA 8.742 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047103 Css NA 50.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047103 Css NA 7.026 mg/L PBTK NA 50% Rat Human -DTXSID6047103 Css NA 33.28 mg/L PBTK NA 95% Rat Human -DTXSID6047105 Clint NA 9.874 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047105 Fup NA 0.4533 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047105 Vd NA 1.148 L/kg 1compartment NA NA Human Human +DTXSID6047101 TK.Half.Life NA 0.5263 hours 1compartment NA NA Rat Human +DTXSID6047101 Css NA 0.004632 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047101 Css NA 0.03428 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047101 Css NA 0.003891 mg/L PBTK NA 50% Rat Human +DTXSID6047101 Css NA 0.02418 mg/L PBTK NA 95% Rat Human +DTXSID6047103 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047103 Fup 0.0385 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047103 Vd NA 2.899 L/kg 1compartment NA NA Human Human +DTXSID6047103 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID6047103 TK.Half.Life NA 37.07 hours 1compartment NA NA Human Human +DTXSID6047103 Css NA 1.575 mg/L 3compartmentss NA 50% Human Human +DTXSID6047103 Css NA 10.79 mg/L 3compartmentss NA 95% Human Human +DTXSID6047103 Css NA 1.079 mg/L PBTK NA 50% Human Human +DTXSID6047103 Css NA 7.17 mg/L PBTK NA 95% Human Human +DTXSID6047103 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047103 Fup 0.0385 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047103 Vd NA 2.173 L/kg 1compartment NA NA Rat Human +DTXSID6047103 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6047103 TK.Half.Life NA 6.756 hours 1compartment NA NA Rat Human +DTXSID6047103 Css NA 0.2056 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047103 Css NA 1.158 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047103 Css NA 0.1388 mg/L PBTK NA 50% Rat Human +DTXSID6047103 Css NA 0.7687 mg/L PBTK NA 95% Rat Human +DTXSID6047105 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047105 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047105 Vd NA 0.8425 L/kg 1compartment NA NA Human Human DTXSID6047105 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047105 TK.Half.Life NA 1.684 hours 1compartment NA NA Human Human -DTXSID6047105 Css NA 0.09749 mg/L 3compartmentss NA 50% Human Human -DTXSID6047105 Css NA 0.7031 mg/L 3compartmentss NA 95% Human Human -DTXSID6047105 Css NA 0.0781 mg/L PBTK NA 50% Human Human -DTXSID6047105 Css NA 0.4907 mg/L PBTK NA 95% Human Human -DTXSID6047105 Clint NA 9.874 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047105 Fup NA 0.4533 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047105 Vd NA 1.006 L/kg 1compartment NA NA Rat Human +DTXSID6047105 TK.Half.Life NA 0.9877 hours 1compartment NA NA Human Human +DTXSID6047105 Css NA 0.0541 mg/L 3compartmentss NA 50% Human Human +DTXSID6047105 Css NA 0.4466 mg/L 3compartmentss NA 95% Human Human +DTXSID6047105 Css NA 0.0407 mg/L PBTK NA 50% Human Human +DTXSID6047105 Css NA 0.3009 mg/L PBTK NA 95% Human Human +DTXSID6047105 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047105 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047105 Vd NA 0.7645 L/kg 1compartment NA NA Rat Human DTXSID6047105 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047105 TK.Half.Life NA 0.7734 hours 1compartment NA NA Rat Human -DTXSID6047105 Css NA 0.05042 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047105 Css NA 0.2879 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047105 Css NA 0.03918 mg/L PBTK NA 50% Rat Human -DTXSID6047105 Css NA 0.1904 mg/L PBTK NA 95% Rat Human +DTXSID6047105 TK.Half.Life NA 0.4624 hours 1compartment NA NA Rat Human +DTXSID6047105 Css NA 0.00676 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047105 Css NA 0.04135 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047105 Css NA 0.005077 mg/L PBTK NA 50% Rat Human +DTXSID6047105 Css NA 0.0279 mg/L PBTK NA 95% Rat Human +DTXSID6047109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047109 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047109 Vd NA 2.012 L/kg 1compartment NA NA Human Human +DTXSID6047109 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047109 TK.Half.Life NA 4.292 hours 1compartment NA NA Human Human +DTXSID6047109 Css NA 0.1639 mg/L 3compartmentss NA 50% Human Human +DTXSID6047109 Css NA 1.111 mg/L 3compartmentss NA 95% Human Human +DTXSID6047109 Css NA 0.1178 mg/L PBTK NA 50% Human Human +DTXSID6047109 Css NA 0.7636 mg/L PBTK NA 95% Human Human +DTXSID6047109 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047109 Fup 0.189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047109 Vd NA 1.549 L/kg 1compartment NA NA Rat Human +DTXSID6047109 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047109 TK.Half.Life NA 1.456 hours 1compartment NA NA Rat Human +DTXSID6047109 Css NA 0.02094 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047109 Css NA 0.1024 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047109 Css NA 0.01495 mg/L PBTK NA 50% Rat Human +DTXSID6047109 Css NA 0.07115 mg/L PBTK NA 95% Rat Human DTXSID6047155 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6047155 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047155 Vd NA 0.6057 L/kg 1compartment NA NA Human Human +DTXSID6047155 Vd NA 0.6217 L/kg 1compartment NA NA Human Human DTXSID6047155 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047155 TK.Half.Life NA 4.63 hours 1compartment NA NA Human Human -DTXSID6047155 Css NA 0.9964 mg/L 3compartmentss NA 50% Human Human -DTXSID6047155 Css NA 5.933 mg/L 3compartmentss NA 95% Human Human -DTXSID6047155 Css NA 0.7897 mg/L PBTK NA 50% Human Human -DTXSID6047155 Css NA 3.798 mg/L PBTK NA 95% Human Human +DTXSID6047155 TK.Half.Life NA 4.754 hours 1compartment NA NA Human Human +DTXSID6047155 Css NA 0.8411 mg/L 3compartmentss NA 50% Human Human +DTXSID6047155 Css NA 5.006 mg/L 3compartmentss NA 95% Human Human +DTXSID6047155 Css NA 0.6738 mg/L PBTK NA 50% Human Human +DTXSID6047155 Css NA 3.19 mg/L PBTK NA 95% Human Human DTXSID6047155 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6047155 Fup NA 0.8461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047155 Vd NA 0.6562 L/kg 1compartment NA NA Rat Human +DTXSID6047155 Vd NA 0.6689 L/kg 1compartment NA NA Rat Human DTXSID6047155 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047155 TK.Half.Life NA 1.71 hours 1compartment NA NA Rat Human -DTXSID6047155 Css NA 0.2553 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047155 Css NA 1.448 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047155 Css NA 0.1961 mg/L PBTK NA 50% Rat Human -DTXSID6047155 Css NA 0.8574 mg/L PBTK NA 95% Rat Human -DTXSID6047157 Clint NA 3.717 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047157 Fup NA 0.1256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047157 Vd NA 2.526 L/kg 1compartment NA NA Human Human -DTXSID6047157 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID6047157 TK.Half.Life NA 43.21 hours 1compartment NA NA Human Human -DTXSID6047157 Css NA 2.223 mg/L 3compartmentss NA 50% Human Human -DTXSID6047157 Css NA 11.41 mg/L 3compartmentss NA 95% Human Human -DTXSID6047157 Css NA 1.553 mg/L PBTK NA 50% Human Human -DTXSID6047157 Css NA 7.577 mg/L PBTK NA 95% Human Human -DTXSID6047157 Clint NA 3.717 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047157 Fup NA 0.1256 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047157 Vd NA 1.909 L/kg 1compartment NA NA Rat Human -DTXSID6047157 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6047157 TK.Half.Life NA 9.972 hours 1compartment NA NA Rat Human -DTXSID6047157 Css NA 1.133 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047157 Css NA 4.024 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047157 Css NA 0.755 mg/L PBTK NA 50% Rat Human -DTXSID6047157 Css NA 2.511 mg/L PBTK NA 95% Rat Human -DTXSID6047280 Clint NA 97.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047280 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047280 Vd NA 2.194 L/kg 1compartment NA NA Human Human +DTXSID6047155 TK.Half.Life NA 1.743 hours 1compartment NA NA Rat Human +DTXSID6047155 Css NA 0.01579 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047155 Css NA 0.1171 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047155 Css NA 0.01204 mg/L PBTK NA 50% Rat Human +DTXSID6047155 Css NA 0.07397 mg/L PBTK NA 95% Rat Human +DTXSID6047157 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047157 Fup 0.0521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047157 Vd NA 2.146 L/kg 1compartment NA NA Human Human +DTXSID6047157 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047157 TK.Half.Life NA 12.04 hours 1compartment NA NA Human Human +DTXSID6047157 Css NA 0.7202 mg/L 3compartmentss NA 50% Human Human +DTXSID6047157 Css NA 5.41 mg/L 3compartmentss NA 95% Human Human +DTXSID6047157 Css NA 0.4734 mg/L PBTK NA 50% Human Human +DTXSID6047157 Css NA 3.402 mg/L PBTK NA 95% Human Human +DTXSID6047157 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047157 Fup 0.0521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047157 Vd NA 1.609 L/kg 1compartment NA NA Rat Human +DTXSID6047157 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047157 TK.Half.Life NA 3.695 hours 1compartment NA NA Rat Human +DTXSID6047157 Css NA 0.09275 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047157 Css NA 0.536 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047157 Css NA 0.06023 mg/L PBTK NA 50% Rat Human +DTXSID6047157 Css NA 0.3359 mg/L PBTK NA 95% Rat Human +DTXSID6047159 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047159 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047159 Vd NA 1.711 L/kg 1compartment NA NA Human Human +DTXSID6047159 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6047159 TK.Half.Life NA 14.36 hours 1compartment NA NA Human Human +DTXSID6047159 Css NA 1.273 mg/L 3compartmentss NA 50% Human Human +DTXSID6047159 Css NA 10.62 mg/L 3compartmentss NA 95% Human Human +DTXSID6047159 Css NA 0.801 mg/L PBTK NA 50% Human Human +DTXSID6047159 Css NA 6.528 mg/L PBTK NA 95% Human Human +DTXSID6047159 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047159 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047159 Vd NA 1.272 L/kg 1compartment NA NA Rat Human +DTXSID6047159 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047159 TK.Half.Life NA 5.169 hours 1compartment NA NA Rat Human +DTXSID6047159 Css NA 0.1618 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047159 Css NA 1.162 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047159 Css NA 0.1001 mg/L PBTK NA 50% Rat Human +DTXSID6047159 Css NA 0.6799 mg/L PBTK NA 95% Rat Human +DTXSID6047280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047280 Fup 0.0468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047280 Vd NA 1.658 L/kg 1compartment NA NA Human Human DTXSID6047280 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047280 TK.Half.Life NA 2.514 hours 1compartment NA NA Human Human -DTXSID6047280 Css NA 0.06302 mg/L 3compartmentss NA 50% Human Human -DTXSID6047280 Css NA 0.5762 mg/L 3compartmentss NA 95% Human Human -DTXSID6047280 Css NA 0.04748 mg/L PBTK NA 50% Human Human -DTXSID6047280 Css NA 0.3929 mg/L PBTK NA 95% Human Human -DTXSID6047280 Clint NA 97.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047280 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047280 Vd NA 2.027 L/kg 1compartment NA NA Rat Human +DTXSID6047280 TK.Half.Life NA 5.523 hours 1compartment NA NA Human Human +DTXSID6047280 Css NA 0.3888 mg/L 3compartmentss NA 50% Human Human +DTXSID6047280 Css NA 3.299 mg/L 3compartmentss NA 95% Human Human +DTXSID6047280 Css NA 0.2772 mg/L PBTK NA 50% Human Human +DTXSID6047280 Css NA 2.132 mg/L PBTK NA 95% Human Human +DTXSID6047280 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047280 Fup 0.0468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047280 Vd NA 1.557 L/kg 1compartment NA NA Rat Human DTXSID6047280 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047280 TK.Half.Life NA 1.172 hours 1compartment NA NA Rat Human -DTXSID6047280 Css NA 0.03582 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047280 Css NA 0.2569 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047280 Css NA 0.02591 mg/L PBTK NA 50% Rat Human -DTXSID6047280 Css NA 0.1654 mg/L PBTK NA 95% Rat Human +DTXSID6047280 TK.Half.Life NA 3.105 hours 1compartment NA NA Rat Human +DTXSID6047280 Css NA 0.05046 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047280 Css NA 0.3615 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047280 Css NA 0.03523 mg/L PBTK NA 50% Rat Human +DTXSID6047280 Css NA 0.2284 mg/L PBTK NA 95% Rat Human DTXSID6047282 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6047282 Fup 0.0414 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6047282 Vd NA 0.3107 L/kg 1compartment NA NA Human Human -DTXSID6047282 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID6047282 TK.Half.Life NA 48.57 hours 1compartment NA NA Human Human -DTXSID6047282 Css NA 17.84 mg/L 3compartmentss NA 50% Human Human -DTXSID6047282 Css NA 75.08 mg/L 3compartmentss NA 95% Human Human -DTXSID6047282 Css NA 11.24 mg/L PBTK NA 50% Human Human -DTXSID6047282 Css NA 44.38 mg/L PBTK NA 95% Human Human +DTXSID6047282 Vd NA 0.269 L/kg 1compartment NA NA Human Human +DTXSID6047282 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID6047282 TK.Half.Life NA 42.03 hours 1compartment NA NA Human Human +DTXSID6047282 Css NA 15.46 mg/L 3compartmentss NA 50% Human Human +DTXSID6047282 Css NA 66.7 mg/L 3compartmentss NA 95% Human Human +DTXSID6047282 Css NA 9.519 mg/L PBTK NA 50% Human Human +DTXSID6047282 Css NA 39.31 mg/L PBTK NA 95% Human Human DTXSID6047282 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6047282 Fup 0.0414 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6047282 Vd NA 0.3021 L/kg 1compartment NA NA Rat Human -DTXSID6047282 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6047282 TK.Half.Life NA 16.08 hours 1compartment NA NA Rat Human -DTXSID6047282 Css NA 4.996 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047282 Css NA 18.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047282 Css NA 2.937 mg/L PBTK NA 50% Rat Human -DTXSID6047282 Css NA 10.03 mg/L PBTK NA 95% Rat Human -DTXSID6047284 Clint NA 15.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047284 Fup NA 0.6471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047284 Vd NA 2.249 L/kg 1compartment NA NA Human Human +DTXSID6047282 Vd NA 0.2634 L/kg 1compartment NA NA Rat Human +DTXSID6047282 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6047282 TK.Half.Life NA 14.02 hours 1compartment NA NA Rat Human +DTXSID6047282 Css NA 0.3727 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047282 Css NA 2.295 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047282 Css NA 0.2202 mg/L PBTK NA 50% Rat Human +DTXSID6047282 Css NA 1.317 mg/L PBTK NA 95% Rat Human +DTXSID6047284 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047284 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047284 Vd NA 1.84 L/kg 1compartment NA NA Human Human DTXSID6047284 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047284 TK.Half.Life NA 1.877 hours 1compartment NA NA Human Human -DTXSID6047284 Css NA 0.03762 mg/L 3compartmentss NA 50% Human Human -DTXSID6047284 Css NA 0.4358 mg/L 3compartmentss NA 95% Human Human -DTXSID6047284 Css NA 0.03804 mg/L PBTK NA 50% Human Human -DTXSID6047284 Css NA 0.3319 mg/L PBTK NA 95% Human Human -DTXSID6047284 Clint NA 15.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047284 Fup NA 0.6471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047284 Vd NA 2.267 L/kg 1compartment NA NA Rat Human +DTXSID6047284 TK.Half.Life NA 3.044 hours 1compartment NA NA Human Human +DTXSID6047284 Css NA 0.1101 mg/L 3compartmentss NA 50% Human Human +DTXSID6047284 Css NA 0.914 mg/L 3compartmentss NA 95% Human Human +DTXSID6047284 Css NA 0.1026 mg/L PBTK NA 50% Human Human +DTXSID6047284 Css NA 0.6725 mg/L PBTK NA 95% Human Human +DTXSID6047284 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047284 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047284 Vd NA 1.847 L/kg 1compartment NA NA Rat Human DTXSID6047284 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047284 TK.Half.Life NA 0.9871 hours 1compartment NA NA Rat Human -DTXSID6047284 Css NA 0.01834 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047284 Css NA 0.1911 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047284 Css NA 0.01885 mg/L PBTK NA 50% Rat Human -DTXSID6047284 Css NA 0.1346 mg/L PBTK NA 95% Rat Human +DTXSID6047284 TK.Half.Life NA 1.71 hours 1compartment NA NA Rat Human +DTXSID6047284 Css NA 0.01246 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047284 Css NA 0.08321 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047284 Css NA 0.01181 mg/L PBTK NA 50% Rat Human +DTXSID6047284 Css NA 0.05936 mg/L PBTK NA 95% Rat Human DTXSID6047286 Clint 9.898 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID6047286 Fup 0.2659 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID6047286 Vd NA 2.741 L/kg 1compartment NA NA Human Human -DTXSID6047286 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6047286 TK.Half.Life NA 14.61 hours 1compartment NA NA Human Human -DTXSID6047286 Css NA 0.5524 mg/L 3compartmentss NA 50% Human Human -DTXSID6047286 Css NA 3.075 mg/L 3compartmentss NA 95% Human Human -DTXSID6047286 Css NA 0.4072 mg/L PBTK NA 50% Human Human -DTXSID6047286 Css NA 2.143 mg/L PBTK NA 95% Human Human +DTXSID6047286 Vd NA 2.986 L/kg 1compartment NA NA Human Human +DTXSID6047286 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6047286 TK.Half.Life NA 29.12 hours 1compartment NA NA Human Human +DTXSID6047286 Css NA 0.9662 mg/L 3compartmentss NA 50% Human Human +DTXSID6047286 Css NA 5.628 mg/L 3compartmentss NA 95% Human Human +DTXSID6047286 Css NA 0.6936 mg/L PBTK NA 50% Human Human +DTXSID6047286 Css NA 3.874 mg/L PBTK NA 95% Human Human DTXSID6047286 Clint 9.898 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID6047286 Fup 0.2659 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID6047286 Vd NA 2.079 L/kg 1compartment NA NA Rat Human -DTXSID6047286 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047286 TK.Half.Life NA 3.213 hours 1compartment NA NA Rat Human -DTXSID6047286 Css NA 0.2954 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047286 Css NA 1.229 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047286 Css NA 0.2082 mg/L PBTK NA 50% Rat Human -DTXSID6047286 Css NA 0.8352 mg/L PBTK NA 95% Rat Human -DTXSID6047288 Clint NA 22.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047288 Fup NA 0.1351 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047288 Vd NA 1694 L/kg 1compartment NA NA Human Human -DTXSID6047288 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6047288 TK.Half.Life NA 48000 hours 1compartment NA NA Human Human -DTXSID6047288 Css NA 0.008414 mg/L 3compartmentss NA 50% Human Human -DTXSID6047288 Css NA 0.05503 mg/L 3compartmentss NA 95% Human Human -DTXSID6047288 Css NA 2.374 mg/L PBTK NA 50% Human Human -DTXSID6047288 Css NA 13.59 mg/L PBTK NA 95% Human Human -DTXSID6047288 Clint NA 22.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047288 Fup NA 0.1351 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047288 Vd NA 1563 L/kg 1compartment NA NA Rat Human -DTXSID6047288 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6047288 TK.Half.Life NA 7436 hours 1compartment NA NA Rat Human -DTXSID6047288 Css NA 0.004216 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047288 Css NA 0.01909 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047288 Css NA 1.289 mg/L PBTK NA 50% Rat Human -DTXSID6047288 Css NA 5.428 mg/L PBTK NA 95% Rat Human -DTXSID6047311 Clint NA 55.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047311 Fup NA 0.03 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047311 Vd NA 33.29 L/kg 1compartment NA NA Human Human -DTXSID6047311 Days.Css NA 81 Days PBTK NA NA Human Human -DTXSID6047311 TK.Half.Life NA 384.4 hours 1compartment NA NA Human Human -DTXSID6047311 Css NA 0.2741 mg/L 3compartmentss NA 50% Human Human -DTXSID6047311 Css NA 1.661 mg/L 3compartmentss NA 95% Human Human -DTXSID6047311 Css NA 0.9608 mg/L PBTK NA 50% Human Human -DTXSID6047311 Css NA 5.323 mg/L PBTK NA 95% Human Human -DTXSID6047311 Clint NA 55.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047311 Fup NA 0.03 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047311 Vd NA 27.62 L/kg 1compartment NA NA Rat Human -DTXSID6047311 Days.Css NA 52 Days PBTK NA NA Rat Human -DTXSID6047311 TK.Half.Life NA 55.36 hours 1compartment NA NA Rat Human -DTXSID6047311 Css NA 0.1405 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047311 Css NA 0.6342 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047311 Css NA 0.5218 mg/L PBTK NA 50% Rat Human -DTXSID6047311 Css NA 2.261 mg/L PBTK NA 95% Rat Human -DTXSID6047313 Clint NA 71.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047313 Fup NA 0.1516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047313 Vd NA 4.342 L/kg 1compartment NA NA Human Human +DTXSID6047286 Vd NA 2.252 L/kg 1compartment NA NA Rat Human +DTXSID6047286 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6047286 TK.Half.Life NA 4.916 hours 1compartment NA NA Rat Human +DTXSID6047286 Css NA 0.05347 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047286 Css NA 0.2951 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047286 Css NA 0.03787 mg/L PBTK NA 50% Rat Human +DTXSID6047286 Css NA 0.1965 mg/L PBTK NA 95% Rat Human +DTXSID6047311 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047311 Fup 0.0367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047311 Vd NA 31.63 L/kg 1compartment NA NA Human Human +DTXSID6047311 Days.Css NA 66 Days PBTK NA NA Human Human +DTXSID6047311 TK.Half.Life NA 321.2 hours 1compartment NA NA Human Human +DTXSID6047311 Css NA 0.2597 mg/L 3compartmentss NA 50% Human Human +DTXSID6047311 Css NA 2.251 mg/L 3compartmentss NA 95% Human Human +DTXSID6047311 Css NA 0.8145 mg/L PBTK NA 50% Human Human +DTXSID6047311 Css NA 5.151 mg/L PBTK NA 95% Human Human +DTXSID6047311 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047311 Fup 0.0367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047311 Vd NA 26.19 L/kg 1compartment NA NA Rat Human +DTXSID6047311 Days.Css NA 42 Days PBTK NA NA Rat Human +DTXSID6047311 TK.Half.Life NA 71.41 hours 1compartment NA NA Rat Human +DTXSID6047311 Css NA 0.01164 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047311 Css NA 0.1139 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047311 Css NA 0.04005 mg/L PBTK NA 50% Rat Human +DTXSID6047311 Css NA 0.2664 mg/L PBTK NA 95% Rat Human +DTXSID6047313 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047313 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047313 Vd NA 0.6144 L/kg 1compartment NA NA Human Human DTXSID6047313 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047313 TK.Half.Life NA 2.888 hours 1compartment NA NA Human Human -DTXSID6047313 Css NA 0.01734 mg/L 3compartmentss NA 50% Human Human -DTXSID6047313 Css NA 0.1577 mg/L 3compartmentss NA 95% Human Human -DTXSID6047313 Css NA 0.01906 mg/L PBTK NA 50% Human Human -DTXSID6047313 Css NA 0.1395 mg/L PBTK NA 95% Human Human -DTXSID6047313 Clint NA 71.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047313 Fup NA 0.1516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047313 Vd NA 4.132 L/kg 1compartment NA NA Rat Human +DTXSID6047313 TK.Half.Life NA 2.466 hours 1compartment NA NA Human Human +DTXSID6047313 Css NA 0.419 mg/L 3compartmentss NA 50% Human Human +DTXSID6047313 Css NA 2.4 mg/L 3compartmentss NA 95% Human Human +DTXSID6047313 Css NA 0.279 mg/L PBTK NA 50% Human Human +DTXSID6047313 Css NA 1.501 mg/L PBTK NA 95% Human Human +DTXSID6047313 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047313 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047313 Vd NA 0.5441 L/kg 1compartment NA NA Rat Human DTXSID6047313 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047313 TK.Half.Life NA 1.24 hours 1compartment NA NA Rat Human -DTXSID6047313 Css NA 0.009345 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047313 Css NA 0.06671 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047313 Css NA 0.01021 mg/L PBTK NA 50% Rat Human -DTXSID6047313 Css NA 0.05854 mg/L PBTK NA 95% Rat Human -DTXSID6047315 Clint NA 12.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047315 Fup NA 0.0037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047315 Vd NA 9.53 L/kg 1compartment NA NA Human Human -DTXSID6047315 Days.Css NA 89 Days PBTK NA NA Human Human -DTXSID6047315 TK.Half.Life NA 407.7 hours 1compartment NA NA Human Human -DTXSID6047315 Css NA 3.923 mg/L 3compartmentss NA 50% Human Human -DTXSID6047315 Css NA 32.02 mg/L 3compartmentss NA 95% Human Human -DTXSID6047315 Css NA 4.255 mg/L PBTK NA 50% Human Human -DTXSID6047315 Css NA 29.59 mg/L PBTK NA 95% Human Human -DTXSID6047315 Clint NA 12.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047315 Fup NA 0.0037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047315 Vd NA 7.488 L/kg 1compartment NA NA Rat Human -DTXSID6047315 Days.Css NA 52 Days PBTK NA NA Rat Human -DTXSID6047315 TK.Half.Life NA 119.6 hours 1compartment NA NA Rat Human -DTXSID6047315 Css NA 2.132 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047315 Css NA 13.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047315 Css NA 2.3 mg/L PBTK NA 50% Rat Human -DTXSID6047315 Css NA 12.53 mg/L PBTK NA 95% Rat Human +DTXSID6047313 TK.Half.Life NA 1.277 hours 1compartment NA NA Rat Human +DTXSID6047313 Css NA 0.04976 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047313 Css NA 0.2119 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047313 Css NA 0.03276 mg/L PBTK NA 50% Rat Human +DTXSID6047313 Css NA 0.1299 mg/L PBTK NA 95% Rat Human +DTXSID6047315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047315 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047315 Vd NA 9.195 L/kg 1compartment NA NA Human Human +DTXSID6047315 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID6047315 TK.Half.Life NA 62.9 hours 1compartment NA NA Human Human +DTXSID6047315 Css NA 0.5184 mg/L 3compartmentss NA 50% Human Human +DTXSID6047315 Css NA 6.431 mg/L 3compartmentss NA 95% Human Human +DTXSID6047315 Css NA 0.599 mg/L PBTK NA 50% Human Human +DTXSID6047315 Css NA 5.314 mg/L PBTK NA 95% Human Human +DTXSID6047315 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047315 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047315 Vd NA 7.286 L/kg 1compartment NA NA Rat Human +DTXSID6047315 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID6047315 TK.Half.Life NA 25.16 hours 1compartment NA NA Rat Human +DTXSID6047315 Css NA 0.0236 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047315 Css NA 0.3175 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047315 Css NA 0.02889 mg/L PBTK NA 50% Rat Human +DTXSID6047315 Css NA 0.2665 mg/L PBTK NA 95% Rat Human +DTXSID6047317 Clint 40 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID6047317 Fup 0.013 NA NA Williamson 2020 NA Human Human +DTXSID6047317 Vd NA 2.812 L/kg 1compartment NA NA Human Human +DTXSID6047317 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6047317 TK.Half.Life NA 29.75 hours 1compartment NA NA Human Human +DTXSID6047317 Css NA 1.171 mg/L 3compartmentss NA 50% Human Human +DTXSID6047317 Css NA 8.285 mg/L 3compartmentss NA 95% Human Human +DTXSID6047317 Css NA 0.7926 mg/L PBTK NA 50% Human Human +DTXSID6047317 Css NA 5.388 mg/L PBTK NA 95% Human Human +DTXSID6047317 Clint 40 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID6047317 Fup 0.013 NA NA Williamson 2020 NA Rat Human +DTXSID6047317 Vd NA 2.101 L/kg 1compartment NA NA Rat Human +DTXSID6047317 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6047317 TK.Half.Life NA 5.889 hours 1compartment NA NA Rat Human +DTXSID6047317 Css NA 0.04432 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047317 Css NA 0.3459 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047317 Css NA 0.02868 mg/L PBTK NA 50% Rat Human +DTXSID6047317 Css NA 0.2151 mg/L PBTK NA 95% Rat Human DTXSID6047319 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6047319 Fup 0.187 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6047319 Vd NA 2.472 L/kg 1compartment NA NA Human Human -DTXSID6047319 Days.Css NA 52 Days PBTK NA NA Human Human -DTXSID6047319 TK.Half.Life NA 243.7 hours 1compartment NA NA Human Human -DTXSID6047319 Css NA 10.67 mg/L 3compartmentss NA 50% Human Human -DTXSID6047319 Css NA 29.85 mg/L 3compartmentss NA 95% Human Human -DTXSID6047319 Css NA 7.719 mg/L PBTK NA 50% Human Human -DTXSID6047319 Css NA 20 mg/L PBTK NA 95% Human Human +DTXSID6047319 Vd NA 2.837 L/kg 1compartment NA NA Human Human +DTXSID6047319 Days.Css NA 138 Days PBTK NA NA Human Human +DTXSID6047319 TK.Half.Life NA 575.7 hours 1compartment NA NA Human Human +DTXSID6047319 Css NA 21.4 mg/L 3compartmentss NA 50% Human Human +DTXSID6047319 Css NA 60.41 mg/L 3compartmentss NA 95% Human Human +DTXSID6047319 Css NA 15.35 mg/L PBTK NA 50% Human Human +DTXSID6047319 Css NA 40.1 mg/L PBTK NA 95% Human Human DTXSID6047319 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6047319 Fup 0.187 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6047319 Vd NA 1.88 L/kg 1compartment NA NA Rat Human -DTXSID6047319 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID6047319 TK.Half.Life NA 31.93 hours 1compartment NA NA Rat Human -DTXSID6047319 Css NA 2.865 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047319 Css NA 6.418 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047319 Css NA 2.001 mg/L PBTK NA 50% Rat Human -DTXSID6047319 Css NA 3.976 mg/L PBTK NA 95% Rat Human +DTXSID6047319 Vd NA 2.143 L/kg 1compartment NA NA Rat Human +DTXSID6047319 Days.Css NA 33 Days PBTK NA NA Rat Human +DTXSID6047319 TK.Half.Life NA 54.58 hours 1compartment NA NA Rat Human +DTXSID6047319 Css NA 1.35 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047319 Css NA 3.033 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047319 Css NA 0.9657 mg/L PBTK NA 50% Rat Human +DTXSID6047319 Css NA 1.933 mg/L PBTK NA 95% Rat Human DTXSID6047363 Clint 5.464 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID6047363 Fup 0.5097 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID6047363 Vd NA 5.575 L/kg 1compartment NA NA Human Human +DTXSID6047363 Vd NA 5.601 L/kg 1compartment NA NA Human Human DTXSID6047363 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047363 TK.Half.Life NA 7.032 hours 1compartment NA NA Human Human -DTXSID6047363 Css NA 0.05553 mg/L 3compartmentss NA 50% Human Human -DTXSID6047363 Css NA 0.571 mg/L 3compartmentss NA 95% Human Human -DTXSID6047363 Css NA 0.09587 mg/L PBTK NA 50% Human Human -DTXSID6047363 Css NA 0.6162 mg/L PBTK NA 95% Human Human +DTXSID6047363 TK.Half.Life NA 7.046 hours 1compartment NA NA Human Human +DTXSID6047363 Css NA 0.05174 mg/L 3compartmentss NA 50% Human Human +DTXSID6047363 Css NA 0.5609 mg/L 3compartmentss NA 95% Human Human +DTXSID6047363 Css NA 0.08953 mg/L PBTK NA 50% Human Human +DTXSID6047363 Css NA 0.586 mg/L PBTK NA 95% Human Human DTXSID6047363 Clint 5.464 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID6047363 Fup 0.5097 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID6047363 Vd NA 5.671 L/kg 1compartment NA NA Rat Human +DTXSID6047363 Vd NA 5.696 L/kg 1compartment NA NA Rat Human DTXSID6047363 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047363 TK.Half.Life NA 4.171 hours 1compartment NA NA Rat Human -DTXSID6047363 Css NA 0.02613 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047363 Css NA 0.2333 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047363 Css NA 0.04666 mg/L PBTK NA 50% Rat Human -DTXSID6047363 Css NA 0.23 mg/L PBTK NA 95% Rat Human -DTXSID6047369 Clint NA 14.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047369 Fup NA 0.0029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047369 Vd NA 3.032 L/kg 1compartment NA NA Human Human -DTXSID6047369 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID6047369 TK.Half.Life NA 142.2 hours 1compartment NA NA Human Human -DTXSID6047369 Css NA 5.698 mg/L 3compartmentss NA 50% Human Human -DTXSID6047369 Css NA 33.88 mg/L 3compartmentss NA 95% Human Human -DTXSID6047369 Css NA 3.946 mg/L PBTK NA 50% Human Human -DTXSID6047369 Css NA 22.76 mg/L PBTK NA 95% Human Human -DTXSID6047369 Clint NA 14.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047369 Fup NA 0.0029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047369 Vd NA 2.269 L/kg 1compartment NA NA Rat Human -DTXSID6047369 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID6047369 TK.Half.Life NA 21.1 hours 1compartment NA NA Rat Human -DTXSID6047369 Css NA 3.258 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047369 Css NA 14.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047369 Css NA 2.134 mg/L PBTK NA 50% Rat Human -DTXSID6047369 Css NA 9.709 mg/L PBTK NA 95% Rat Human -DTXSID6047444 Clint NA 3.109 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047444 Fup NA 0.2167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047444 Vd NA 1.763 L/kg 1compartment NA NA Human Human -DTXSID6047444 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6047444 TK.Half.Life NA 12.43 hours 1compartment NA NA Human Human -DTXSID6047444 Css NA 0.7794 mg/L 3compartmentss NA 50% Human Human -DTXSID6047444 Css NA 3.625 mg/L 3compartmentss NA 95% Human Human -DTXSID6047444 Css NA 0.5687 mg/L PBTK NA 50% Human Human -DTXSID6047444 Css NA 2.468 mg/L PBTK NA 95% Human Human -DTXSID6047444 Clint NA 3.109 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047444 Fup NA 0.2167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047444 Vd NA 1.382 L/kg 1compartment NA NA Rat Human +DTXSID6047363 TK.Half.Life NA 4.178 hours 1compartment NA NA Rat Human +DTXSID6047363 Css NA 0.005658 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047363 Css NA 0.05333 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047363 Css NA 0.01061 mg/L PBTK NA 50% Rat Human +DTXSID6047363 Css NA 0.05425 mg/L PBTK NA 95% Rat Human +DTXSID6047369 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047369 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047369 Vd NA 0.2437 L/kg 1compartment NA NA Human Human +DTXSID6047369 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047369 TK.Half.Life NA 0.6075 hours 1compartment NA NA Human Human +DTXSID6047369 Css NA 0.2316 mg/L 3compartmentss NA 50% Human Human +DTXSID6047369 Css NA 1.9 mg/L 3compartmentss NA 95% Human Human +DTXSID6047369 Css NA 0.1411 mg/L PBTK NA 50% Human Human +DTXSID6047369 Css NA 1.126 mg/L PBTK NA 95% Human Human +DTXSID6047369 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047369 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047369 Vd NA 0.2517 L/kg 1compartment NA NA Rat Human +DTXSID6047369 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047369 TK.Half.Life NA 0.3693 hours 1compartment NA NA Rat Human +DTXSID6047369 Css NA 0.01137 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047369 Css NA 0.1043 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047369 Css NA 0.006658 mg/L PBTK NA 50% Rat Human +DTXSID6047369 Css NA 0.05939 mg/L PBTK NA 95% Rat Human +DTXSID6047440 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047440 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047440 Vd NA 1.343 L/kg 1compartment NA NA Human Human +DTXSID6047440 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047440 TK.Half.Life NA 3.012 hours 1compartment NA NA Human Human +DTXSID6047440 Css NA 0.2112 mg/L 3compartmentss NA 50% Human Human +DTXSID6047440 Css NA 1.615 mg/L 3compartmentss NA 95% Human Human +DTXSID6047440 Css NA 0.1424 mg/L PBTK NA 50% Human Human +DTXSID6047440 Css NA 1.039 mg/L PBTK NA 95% Human Human +DTXSID6047440 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047440 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047440 Vd NA 1.047 L/kg 1compartment NA NA Rat Human +DTXSID6047440 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047440 TK.Half.Life NA 1.217 hours 1compartment NA NA Rat Human +DTXSID6047440 Css NA 0.02714 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047440 Css NA 0.1636 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047440 Css NA 0.01785 mg/L PBTK NA 50% Rat Human +DTXSID6047440 Css NA 0.1019 mg/L PBTK NA 95% Rat Human +DTXSID6047444 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047444 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047444 Vd NA 1.625 L/kg 1compartment NA NA Human Human +DTXSID6047444 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047444 TK.Half.Life NA 3.062 hours 1compartment NA NA Human Human +DTXSID6047444 Css NA 0.1344 mg/L 3compartmentss NA 50% Human Human +DTXSID6047444 Css NA 0.948 mg/L 3compartmentss NA 95% Human Human +DTXSID6047444 Css NA 0.09624 mg/L PBTK NA 50% Human Human +DTXSID6047444 Css NA 0.6466 mg/L PBTK NA 95% Human Human +DTXSID6047444 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047444 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047444 Vd NA 1.275 L/kg 1compartment NA NA Rat Human DTXSID6047444 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047444 TK.Half.Life NA 4.335 hours 1compartment NA NA Rat Human -DTXSID6047444 Css NA 0.3722 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047444 Css NA 1.312 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047444 Css NA 0.2604 mg/L PBTK NA 50% Rat Human -DTXSID6047444 Css NA 0.8206 mg/L PBTK NA 95% Rat Human -DTXSID6047446 Clint NA 10.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047446 Fup NA 0.0676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047446 Vd NA 1.903 L/kg 1compartment NA NA Human Human -DTXSID6047446 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6047446 TK.Half.Life NA 13.97 hours 1compartment NA NA Human Human -DTXSID6047446 Css NA 0.9603 mg/L 3compartmentss NA 50% Human Human -DTXSID6047446 Css NA 5.83 mg/L 3compartmentss NA 95% Human Human -DTXSID6047446 Css NA 0.6438 mg/L PBTK NA 50% Human Human -DTXSID6047446 Css NA 3.739 mg/L PBTK NA 95% Human Human -DTXSID6047446 Clint NA 10.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047446 Fup NA 0.0676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047446 Vd NA 1.464 L/kg 1compartment NA NA Rat Human -DTXSID6047446 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047446 TK.Half.Life NA 4.962 hours 1compartment NA NA Rat Human -DTXSID6047446 Css NA 0.5204 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047446 Css NA 2.328 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047446 Css NA 0.33 mg/L PBTK NA 50% Rat Human -DTXSID6047446 Css NA 1.441 mg/L PBTK NA 95% Rat Human -DTXSID6047448 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047448 Fup NA 0.3317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047448 Vd NA 0.786 L/kg 1compartment NA NA Human Human -DTXSID6047448 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6047448 TK.Half.Life NA 15.34 hours 1compartment NA NA Human Human -DTXSID6047448 Css NA 1.968 mg/L 3compartmentss NA 50% Human Human -DTXSID6047448 Css NA 8.505 mg/L 3compartmentss NA 95% Human Human -DTXSID6047448 Css NA 1.618 mg/L PBTK NA 50% Human Human -DTXSID6047448 Css NA 5.687 mg/L PBTK NA 95% Human Human -DTXSID6047448 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047448 Fup NA 0.3317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047448 Vd NA 0.7848 L/kg 1compartment NA NA Rat Human -DTXSID6047448 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047448 TK.Half.Life NA 5.216 hours 1compartment NA NA Rat Human -DTXSID6047448 Css NA 0.531 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047448 Css NA 2.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047448 Css NA 0.4208 mg/L PBTK NA 50% Rat Human -DTXSID6047448 Css NA 1.261 mg/L PBTK NA 95% Rat Human -DTXSID6047498 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047498 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047498 Vd NA 4.485 L/kg 1compartment NA NA Human Human -DTXSID6047498 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6047498 TK.Half.Life NA 216800 hours 1compartment NA NA Human Human -DTXSID6047498 Css NA 4834 mg/L 3compartmentss NA 50% Human Human -DTXSID6047498 Css NA 10820 mg/L 3compartmentss NA 95% Human Human -DTXSID6047498 Css NA 3754 mg/L PBTK NA 50% Human Human -DTXSID6047498 Css NA 8015 mg/L PBTK NA 95% Human Human -DTXSID6047498 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047498 Fup NA 0.0058 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047498 Vd NA 3.408 L/kg 1compartment NA NA Rat Human -DTXSID6047498 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6047498 TK.Half.Life NA 14370 hours 1compartment NA NA Rat Human -DTXSID6047498 Css NA 1346 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047498 Css NA 1891 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047498 Css NA 1011 mg/L PBTK NA 50% Rat Human -DTXSID6047498 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID6047523 Clint NA 3.599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047523 Fup NA 0.126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047523 Vd NA 0.3574 L/kg 1compartment NA NA Human Human +DTXSID6047444 TK.Half.Life NA 1.169 hours 1compartment NA NA Rat Human +DTXSID6047444 Css NA 0.017 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047444 Css NA 0.08724 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047444 Css NA 0.01211 mg/L PBTK NA 50% Rat Human +DTXSID6047444 Css NA 0.05947 mg/L PBTK NA 95% Rat Human +DTXSID6047446 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047446 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047446 Vd NA 2.083 L/kg 1compartment NA NA Human Human +DTXSID6047446 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6047446 TK.Half.Life NA 21.41 hours 1compartment NA NA Human Human +DTXSID6047446 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human +DTXSID6047446 Css NA 8.477 mg/L 3compartmentss NA 95% Human Human +DTXSID6047446 Css NA 0.9338 mg/L PBTK NA 50% Human Human +DTXSID6047446 Css NA 5.415 mg/L PBTK NA 95% Human Human +DTXSID6047446 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047446 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047446 Vd NA 1.607 L/kg 1compartment NA NA Rat Human +DTXSID6047446 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6047446 TK.Half.Life NA 6.979 hours 1compartment NA NA Rat Human +DTXSID6047446 Css NA 0.1677 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047446 Css NA 0.7543 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047446 Css NA 0.1124 mg/L PBTK NA 50% Rat Human +DTXSID6047446 Css NA 0.4747 mg/L PBTK NA 95% Rat Human +DTXSID6047490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047490 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047490 Vd NA 3.115 L/kg 1compartment NA NA Human Human +DTXSID6047490 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID6047490 TK.Half.Life NA 80.9 hours 1compartment NA NA Human Human +DTXSID6047490 Css NA 3.012 mg/L 3compartmentss NA 50% Human Human +DTXSID6047490 Css NA 19.36 mg/L 3compartmentss NA 95% Human Human +DTXSID6047490 Css NA 2.101 mg/L PBTK NA 50% Human Human +DTXSID6047490 Css NA 12.94 mg/L PBTK NA 95% Human Human +DTXSID6047490 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047490 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047490 Vd NA 2.334 L/kg 1compartment NA NA Rat Human +DTXSID6047490 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID6047490 TK.Half.Life NA 11.05 hours 1compartment NA NA Rat Human +DTXSID6047490 Css NA 0.3969 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047490 Css NA 2.241 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047490 Css NA 0.2732 mg/L PBTK NA 50% Rat Human +DTXSID6047490 Css NA 1.518 mg/L PBTK NA 95% Rat Human +DTXSID6047523 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047523 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047523 Vd NA 0.4388 L/kg 1compartment NA NA Human Human DTXSID6047523 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047523 TK.Half.Life NA 2.843 hours 1compartment NA NA Human Human -DTXSID6047523 Css NA 1.165 mg/L 3compartmentss NA 50% Human Human -DTXSID6047523 Css NA 7.255 mg/L 3compartmentss NA 95% Human Human -DTXSID6047523 Css NA 0.7462 mg/L PBTK NA 50% Human Human -DTXSID6047523 Css NA 4.425 mg/L PBTK NA 95% Human Human -DTXSID6047523 Clint NA 3.599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047523 Fup NA 0.126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047523 Vd NA 0.3573 L/kg 1compartment NA NA Rat Human +DTXSID6047523 TK.Half.Life NA 0.7939 hours 1compartment NA NA Human Human +DTXSID6047523 Css NA 0.1376 mg/L 3compartmentss NA 50% Human Human +DTXSID6047523 Css NA 0.9297 mg/L 3compartmentss NA 95% Human Human +DTXSID6047523 Css NA 0.0963 mg/L PBTK NA 50% Human Human +DTXSID6047523 Css NA 0.6024 mg/L PBTK NA 95% Human Human +DTXSID6047523 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047523 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047523 Vd NA 0.4602 L/kg 1compartment NA NA Rat Human DTXSID6047523 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047523 TK.Half.Life NA 1.67 hours 1compartment NA NA Rat Human -DTXSID6047523 Css NA 0.5798 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047523 Css NA 2.706 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047523 Css NA 0.3469 mg/L PBTK NA 50% Rat Human -DTXSID6047523 Css NA 1.513 mg/L PBTK NA 95% Rat Human +DTXSID6047523 TK.Half.Life NA 0.4609 hours 1compartment NA NA Rat Human +DTXSID6047523 Css NA 0.01625 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047523 Css NA 0.08265 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047523 Css NA 0.01138 mg/L PBTK NA 50% Rat Human +DTXSID6047523 Css NA 0.05188 mg/L PBTK NA 95% Rat Human DTXSID6047525 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID6047525 Fup 0.361 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID6047525 Vd NA 1.68 L/kg 1compartment NA NA Human Human -DTXSID6047525 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID6047525 TK.Half.Life NA 41.43 hours 1compartment NA NA Human Human -DTXSID6047525 Css NA 2.489 mg/L 3compartmentss NA 50% Human Human -DTXSID6047525 Css NA 8.16 mg/L 3compartmentss NA 95% Human Human -DTXSID6047525 Css NA 1.968 mg/L PBTK NA 50% Human Human -DTXSID6047525 Css NA 5.621 mg/L PBTK NA 95% Human Human +DTXSID6047525 Vd NA 0.4873 L/kg 1compartment NA NA Human Human +DTXSID6047525 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047525 TK.Half.Life NA 8.746 hours 1compartment NA NA Human Human +DTXSID6047525 Css NA 1.19 mg/L 3compartmentss NA 50% Human Human +DTXSID6047525 Css NA 4.342 mg/L 3compartmentss NA 95% Human Human +DTXSID6047525 Css NA 0.854 mg/L PBTK NA 50% Human Human +DTXSID6047525 Css NA 2.841 mg/L PBTK NA 95% Human Human DTXSID6047525 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID6047525 Fup 0.361 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID6047525 Vd NA 1.355 L/kg 1compartment NA NA Rat Human -DTXSID6047525 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6047525 TK.Half.Life NA 9.014 hours 1compartment NA NA Rat Human -DTXSID6047525 Css NA 0.6741 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047525 Css NA 1.846 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047525 Css NA 0.5155 mg/L PBTK NA 50% Rat Human -DTXSID6047525 Css NA 1.178 mg/L PBTK NA 95% Rat Human -DTXSID6047527 Clint NA 15.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047527 Fup NA 0.0245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047527 Vd NA 1.323 L/kg 1compartment NA NA Human Human -DTXSID6047527 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6047527 TK.Half.Life NA 13.55 hours 1compartment NA NA Human Human -DTXSID6047527 Css NA 1.59 mg/L 3compartmentss NA 50% Human Human -DTXSID6047527 Css NA 13.82 mg/L 3compartmentss NA 95% Human Human -DTXSID6047527 Css NA 1.046 mg/L PBTK NA 50% Human Human -DTXSID6047527 Css NA 8.595 mg/L PBTK NA 95% Human Human -DTXSID6047527 Clint NA 15.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047527 Fup NA 0.0245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047527 Vd NA 1.009 L/kg 1compartment NA NA Rat Human -DTXSID6047527 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047527 TK.Half.Life NA 5.677 hours 1compartment NA NA Rat Human -DTXSID6047527 Css NA 0.8822 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047527 Css NA 6.507 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047527 Css NA 0.542 mg/L PBTK NA 50% Rat Human -DTXSID6047527 Css NA 3.706 mg/L PBTK NA 95% Rat Human -DTXSID6047529 Clint NA 0.1238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047529 Fup NA 0.7291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047529 Vd NA 0.6918 L/kg 1compartment NA NA Human Human +DTXSID6047525 Vd NA 0.4952 L/kg 1compartment NA NA Rat Human +DTXSID6047525 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047525 TK.Half.Life NA 3.024 hours 1compartment NA NA Rat Human +DTXSID6047525 Css NA 0.007116 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047525 Css NA 0.03075 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047525 Css NA 0.004868 mg/L PBTK NA 50% Rat Human +DTXSID6047525 Css NA 0.01933 mg/L PBTK NA 95% Rat Human +DTXSID6047529 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047529 Fup 0.843 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047529 Vd NA 0.5276 L/kg 1compartment NA NA Human Human DTXSID6047529 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047529 TK.Half.Life NA 5.082 hours 1compartment NA NA Human Human -DTXSID6047529 Css NA 0.8367 mg/L 3compartmentss NA 50% Human Human -DTXSID6047529 Css NA 5.385 mg/L 3compartmentss NA 95% Human Human -DTXSID6047529 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID6047529 Css NA 3.482 mg/L PBTK NA 95% Human Human -DTXSID6047529 Clint NA 0.1238 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047529 Fup NA 0.7291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047529 Vd NA 0.7064 L/kg 1compartment NA NA Rat Human +DTXSID6047529 TK.Half.Life NA 4.049 hours 1compartment NA NA Human Human +DTXSID6047529 Css NA 0.874 mg/L 3compartmentss NA 50% Human Human +DTXSID6047529 Css NA 5.004 mg/L 3compartmentss NA 95% Human Human +DTXSID6047529 Css NA 0.6787 mg/L PBTK NA 50% Human Human +DTXSID6047529 Css NA 3.174 mg/L PBTK NA 95% Human Human +DTXSID6047529 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047529 Fup 0.843 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047529 Vd NA 0.5695 L/kg 1compartment NA NA Rat Human DTXSID6047529 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047529 TK.Half.Life NA 1.939 hours 1compartment NA NA Rat Human -DTXSID6047529 Css NA 0.2419 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047529 Css NA 1.588 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047529 Css NA 0.1942 mg/L PBTK NA 50% Rat Human -DTXSID6047529 Css NA 0.9476 mg/L PBTK NA 95% Rat Human -DTXSID6047654 Clint NA 3.459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047654 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047654 Vd NA 7.451 L/kg 1compartment NA NA Human Human -DTXSID6047654 Days.Css NA 349 Days PBTK NA NA Human Human -DTXSID6047654 TK.Half.Life NA 1374 hours 1compartment NA NA Human Human -DTXSID6047654 Css NA 15.31 mg/L 3compartmentss NA 50% Human Human -DTXSID6047654 Css NA 89.72 mg/L 3compartmentss NA 95% Human Human -DTXSID6047654 Css NA 15.23 mg/L PBTK NA 50% Human Human -DTXSID6047654 Css NA 85.39 mg/L PBTK NA 95% Human Human -DTXSID6047654 Clint NA 3.459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047654 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047654 Vd NA 5.789 L/kg 1compartment NA NA Rat Human -DTXSID6047654 Days.Css NA 196 Days PBTK NA NA Rat Human -DTXSID6047654 TK.Half.Life NA 184.1 hours 1compartment NA NA Rat Human -DTXSID6047654 Css NA 8.506 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047654 Css NA 34.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047654 Css NA 8.275 mg/L PBTK NA 50% Rat Human -DTXSID6047654 Css NA 32.94 mg/L PBTK NA 95% Rat Human -DTXSID6047656 Clint NA 6.594 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047656 Fup NA 0.1879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047656 Vd NA 2.977 L/kg 1compartment NA NA Human Human -DTXSID6047656 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID6047656 TK.Half.Life NA 51.19 hours 1compartment NA NA Human Human -DTXSID6047656 Css NA 2.018 mg/L 3compartmentss NA 50% Human Human -DTXSID6047656 Css NA 10.9 mg/L 3compartmentss NA 95% Human Human -DTXSID6047656 Css NA 1.43 mg/L PBTK NA 50% Human Human -DTXSID6047656 Css NA 7.401 mg/L PBTK NA 95% Human Human -DTXSID6047656 Clint NA 6.594 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047656 Fup NA 0.1879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047656 Vd NA 2.243 L/kg 1compartment NA NA Rat Human -DTXSID6047656 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6047656 TK.Half.Life NA 8.367 hours 1compartment NA NA Rat Human -DTXSID6047656 Css NA 1.074 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047656 Css NA 4.251 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047656 Css NA 0.7333 mg/L PBTK NA 50% Rat Human -DTXSID6047656 Css NA 2.795 mg/L PBTK NA 95% Rat Human -DTXSID6047781 Clint NA 5.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047781 Fup NA 0.8685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047781 Vd NA 4.474 L/kg 1compartment NA NA Human Human +DTXSID6047529 TK.Half.Life NA 1.49 hours 1compartment NA NA Rat Human +DTXSID6047529 Css NA 0.01639 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047529 Css NA 0.1171 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047529 Css NA 0.01212 mg/L PBTK NA 50% Rat Human +DTXSID6047529 Css NA 0.07501 mg/L PBTK NA 95% Rat Human +DTXSID6047604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047604 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047604 Vd NA 1.476 L/kg 1compartment NA NA Human Human +DTXSID6047604 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047604 TK.Half.Life NA 3.164 hours 1compartment NA NA Human Human +DTXSID6047604 Css NA 0.1881 mg/L 3compartmentss NA 50% Human Human +DTXSID6047604 Css NA 1.393 mg/L 3compartmentss NA 95% Human Human +DTXSID6047604 Css NA 0.1291 mg/L PBTK NA 50% Human Human +DTXSID6047604 Css NA 0.9116 mg/L PBTK NA 95% Human Human +DTXSID6047604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047604 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047604 Vd NA 1.149 L/kg 1compartment NA NA Rat Human +DTXSID6047604 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047604 TK.Half.Life NA 1.24 hours 1compartment NA NA Rat Human +DTXSID6047604 Css NA 0.0242 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047604 Css NA 0.1472 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047604 Css NA 0.0164 mg/L PBTK NA 50% Rat Human +DTXSID6047604 Css NA 0.09221 mg/L PBTK NA 95% Rat Human +DTXSID6047606 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047606 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047606 Vd NA 2.22 L/kg 1compartment NA NA Human Human +DTXSID6047606 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047606 TK.Half.Life NA 9.72 hours 1compartment NA NA Human Human +DTXSID6047606 Css NA 0.5138 mg/L 3compartmentss NA 50% Human Human +DTXSID6047606 Css NA 3.42 mg/L 3compartmentss NA 95% Human Human +DTXSID6047606 Css NA 0.3468 mg/L PBTK NA 50% Human Human +DTXSID6047606 Css NA 2.214 mg/L PBTK NA 95% Human Human +DTXSID6047606 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047606 Fup 0.078 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047606 Vd NA 1.671 L/kg 1compartment NA NA Rat Human +DTXSID6047606 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047606 TK.Half.Life NA 2.92 hours 1compartment NA NA Rat Human +DTXSID6047606 Css NA 0.0664 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047606 Css NA 0.3563 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047606 Css NA 0.04409 mg/L PBTK NA 50% Rat Human +DTXSID6047606 Css NA 0.2256 mg/L PBTK NA 95% Rat Human +DTXSID6047608 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047608 Fup 0.0227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047608 Vd NA 2.142 L/kg 1compartment NA NA Human Human +DTXSID6047608 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6047608 TK.Half.Life NA 21.04 hours 1compartment NA NA Human Human +DTXSID6047608 Css NA 1.414 mg/L 3compartmentss NA 50% Human Human +DTXSID6047608 Css NA 11.31 mg/L 3compartmentss NA 95% Human Human +DTXSID6047608 Css NA 0.9123 mg/L PBTK NA 50% Human Human +DTXSID6047608 Css NA 7.021 mg/L PBTK NA 95% Human Human +DTXSID6047608 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047608 Fup 0.0227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047608 Vd NA 1.595 L/kg 1compartment NA NA Rat Human +DTXSID6047608 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6047608 TK.Half.Life NA 6.365 hours 1compartment NA NA Rat Human +DTXSID6047608 Css NA 0.1818 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047608 Css NA 1.219 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047608 Css NA 0.1162 mg/L PBTK NA 50% Rat Human +DTXSID6047608 Css NA 0.7391 mg/L PBTK NA 95% Rat Human +DTXSID6047652 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047652 Fup 0.748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047652 Vd NA 0.9711 L/kg 1compartment NA NA Human Human +DTXSID6047652 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047652 TK.Half.Life NA 8.596 hours 1compartment NA NA Human Human +DTXSID6047652 Css NA 0.8396 mg/L 3compartmentss NA 50% Human Human +DTXSID6047652 Css NA 5.4 mg/L 3compartmentss NA 95% Human Human +DTXSID6047652 Css NA 0.7274 mg/L PBTK NA 50% Human Human +DTXSID6047652 Css NA 3.545 mg/L PBTK NA 95% Human Human +DTXSID6047652 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047652 Fup 0.748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047652 Vd NA 0.9424 L/kg 1compartment NA NA Rat Human +DTXSID6047652 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047652 TK.Half.Life NA 2.793 hours 1compartment NA NA Rat Human +DTXSID6047652 Css NA 0.01608 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047652 Css NA 0.1296 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047652 Css NA 0.0133 mg/L PBTK NA 50% Rat Human +DTXSID6047652 Css NA 0.08535 mg/L PBTK NA 95% Rat Human +DTXSID6047656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047656 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047656 Vd NA 2.838 L/kg 1compartment NA NA Human Human +DTXSID6047656 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6047656 TK.Half.Life NA 18.01 hours 1compartment NA NA Human Human +DTXSID6047656 Css NA 0.7178 mg/L 3compartmentss NA 50% Human Human +DTXSID6047656 Css NA 4.573 mg/L 3compartmentss NA 95% Human Human +DTXSID6047656 Css NA 0.4967 mg/L PBTK NA 50% Human Human +DTXSID6047656 Css NA 3.071 mg/L PBTK NA 95% Human Human +DTXSID6047656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047656 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047656 Vd NA 2.135 L/kg 1compartment NA NA Rat Human +DTXSID6047656 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047656 TK.Half.Life NA 3.669 hours 1compartment NA NA Rat Human +DTXSID6047656 Css NA 0.09146 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047656 Css NA 0.4964 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047656 Css NA 0.06295 mg/L PBTK NA 50% Rat Human +DTXSID6047656 Css NA 0.3336 mg/L PBTK NA 95% Rat Human +DTXSID6047781 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047781 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047781 Vd NA 2.406 L/kg 1compartment NA NA Human Human DTXSID6047781 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047781 TK.Half.Life NA 4.63 hours 1compartment NA NA Human Human -DTXSID6047781 Css NA 0.06225 mg/L 3compartmentss NA 50% Human Human -DTXSID6047781 Css NA 0.6339 mg/L 3compartmentss NA 95% Human Human -DTXSID6047781 Css NA 0.08734 mg/L PBTK NA 50% Human Human -DTXSID6047781 Css NA 0.574 mg/L PBTK NA 95% Human Human -DTXSID6047781 Clint NA 5.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047781 Fup NA 0.8685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047781 Vd NA 4.573 L/kg 1compartment NA NA Rat Human +DTXSID6047781 TK.Half.Life NA 2.25 hours 1compartment NA NA Human Human +DTXSID6047781 Css NA 0.03574 mg/L 3compartmentss NA 50% Human Human +DTXSID6047781 Css NA 0.3245 mg/L 3compartmentss NA 95% Human Human +DTXSID6047781 Css NA 0.03638 mg/L PBTK NA 50% Human Human +DTXSID6047781 Css NA 0.2689 mg/L PBTK NA 95% Human Human +DTXSID6047781 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047781 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047781 Vd NA 2.428 L/kg 1compartment NA NA Rat Human DTXSID6047781 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047781 TK.Half.Life NA 2.657 hours 1compartment NA NA Rat Human -DTXSID6047781 Css NA 0.02794 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047781 Css NA 0.2624 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047781 Css NA 0.04036 mg/L PBTK NA 50% Rat Human -DTXSID6047781 Css NA 0.2098 mg/L PBTK NA 95% Rat Human -DTXSID6047783 Clint NA 8.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047783 Fup NA 0.0982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047783 Vd NA 3.093 L/kg 1compartment NA NA Human Human -DTXSID6047783 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID6047783 TK.Half.Life NA 123.1 hours 1compartment NA NA Human Human -DTXSID6047783 Css NA 4.88 mg/L 3compartmentss NA 50% Human Human -DTXSID6047783 Css NA 29.36 mg/L 3compartmentss NA 95% Human Human -DTXSID6047783 Css NA 3.416 mg/L PBTK NA 50% Human Human -DTXSID6047783 Css NA 19.95 mg/L PBTK NA 95% Human Human -DTXSID6047783 Clint NA 8.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047783 Fup NA 0.0982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047783 Vd NA 2.319 L/kg 1compartment NA NA Rat Human -DTXSID6047783 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID6047783 TK.Half.Life NA 16.96 hours 1compartment NA NA Rat Human -DTXSID6047783 Css NA 2.703 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047783 Css NA 12.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047783 Css NA 1.799 mg/L PBTK NA 50% Rat Human -DTXSID6047783 Css NA 8.312 mg/L PBTK NA 95% Rat Human -DTXSID6047785 Clint NA 15.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047785 Fup NA 0.0536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047785 Vd NA 1.659 L/kg 1compartment NA NA Human Human +DTXSID6047781 TK.Half.Life NA 1.224 hours 1compartment NA NA Rat Human +DTXSID6047781 Css NA 0.004382 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047781 Css NA 0.02995 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047781 Css NA 0.004575 mg/L PBTK NA 50% Rat Human +DTXSID6047781 Css NA 0.0247 mg/L PBTK NA 95% Rat Human +DTXSID6047783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047783 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047783 Vd NA 0.7058 L/kg 1compartment NA NA Human Human +DTXSID6047783 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6047783 TK.Half.Life NA 0.7401 hours 1compartment NA NA Human Human +DTXSID6047783 Css NA 0.04272 mg/L 3compartmentss NA 50% Human Human +DTXSID6047783 Css NA 0.3742 mg/L 3compartmentss NA 95% Human Human +DTXSID6047783 Css NA 0.03237 mg/L PBTK NA 50% Human Human +DTXSID6047783 Css NA 0.2521 mg/L PBTK NA 95% Human Human +DTXSID6047783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047783 Fup 0.453 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047783 Vd NA 0.6864 L/kg 1compartment NA NA Rat Human +DTXSID6047783 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6047783 TK.Half.Life NA 0.366 hours 1compartment NA NA Rat Human +DTXSID6047783 Css NA 0.005236 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047783 Css NA 0.03713 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047783 Css NA 0.004018 mg/L PBTK NA 50% Rat Human +DTXSID6047783 Css NA 0.02468 mg/L PBTK NA 95% Rat Human +DTXSID6047785 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047785 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047785 Vd NA 0.9388 L/kg 1compartment NA NA Human Human DTXSID6047785 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047785 TK.Half.Life NA 4.466 hours 1compartment NA NA Human Human -DTXSID6047785 Css NA 0.2913 mg/L 3compartmentss NA 50% Human Human -DTXSID6047785 Css NA 2.764 mg/L 3compartmentss NA 95% Human Human -DTXSID6047785 Css NA 0.224 mg/L PBTK NA 50% Human Human -DTXSID6047785 Css NA 1.86 mg/L PBTK NA 95% Human Human -DTXSID6047785 Clint NA 15.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047785 Fup NA 0.0536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047785 Vd NA 1.623 L/kg 1compartment NA NA Rat Human +DTXSID6047785 TK.Half.Life NA 1.672 hours 1compartment NA NA Human Human +DTXSID6047785 Css NA 0.132 mg/L 3compartmentss NA 50% Human Human +DTXSID6047785 Css NA 1.03 mg/L 3compartmentss NA 95% Human Human +DTXSID6047785 Css NA 0.0943 mg/L PBTK NA 50% Human Human +DTXSID6047785 Css NA 0.6722 mg/L PBTK NA 95% Human Human +DTXSID6047785 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047785 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047785 Vd NA 0.9207 L/kg 1compartment NA NA Rat Human DTXSID6047785 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047785 TK.Half.Life NA 2.698 hours 1compartment NA NA Rat Human -DTXSID6047785 Css NA 0.1647 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047785 Css NA 1.194 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047785 Css NA 0.1201 mg/L PBTK NA 50% Rat Human -DTXSID6047785 Css NA 0.7659 mg/L PBTK NA 95% Rat Human -DTXSID6047787 Clint NA 40.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047787 Fup NA 0.0823 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047787 Vd NA 2.329 L/kg 1compartment NA NA Human Human +DTXSID6047785 TK.Half.Life NA 0.9394 hours 1compartment NA NA Rat Human +DTXSID6047785 Css NA 0.01703 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047785 Css NA 0.09978 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047785 Css NA 0.01202 mg/L PBTK NA 50% Rat Human +DTXSID6047785 Css NA 0.06511 mg/L PBTK NA 95% Rat Human +DTXSID6047787 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047787 Fup 0.334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047787 Vd NA 1.717 L/kg 1compartment NA NA Human Human DTXSID6047787 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047787 TK.Half.Life NA 3.386 hours 1compartment NA NA Human Human -DTXSID6047787 Css NA 0.1082 mg/L 3compartmentss NA 50% Human Human -DTXSID6047787 Css NA 0.9702 mg/L 3compartmentss NA 95% Human Human -DTXSID6047787 Css NA 0.08703 mg/L PBTK NA 50% Human Human -DTXSID6047787 Css NA 0.6915 mg/L PBTK NA 95% Human Human -DTXSID6047787 Clint NA 40.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047787 Fup NA 0.0823 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047787 Vd NA 2.239 L/kg 1compartment NA NA Rat Human +DTXSID6047787 TK.Half.Life NA 3.775 hours 1compartment NA NA Human Human +DTXSID6047787 Css NA 0.1614 mg/L 3compartmentss NA 50% Human Human +DTXSID6047787 Css NA 1.146 mg/L 3compartmentss NA 95% Human Human +DTXSID6047787 Css NA 0.1422 mg/L PBTK NA 50% Human Human +DTXSID6047787 Css NA 0.8271 mg/L PBTK NA 95% Human Human +DTXSID6047787 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047787 Fup 0.334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047787 Vd NA 1.727 L/kg 1compartment NA NA Rat Human DTXSID6047787 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047787 TK.Half.Life NA 1.782 hours 1compartment NA NA Rat Human -DTXSID6047787 Css NA 0.06036 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047787 Css NA 0.4501 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047787 Css NA 0.04677 mg/L PBTK NA 50% Rat Human -DTXSID6047787 Css NA 0.2985 mg/L PBTK NA 95% Rat Human -DTXSID6047789 Clint NA 1.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047789 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047789 Vd NA 1.003 L/kg 1compartment NA NA Human Human +DTXSID6047787 TK.Half.Life NA 2.196 hours 1compartment NA NA Rat Human +DTXSID6047787 Css NA 0.01848 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047787 Css NA 0.09922 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047787 Css NA 0.01657 mg/L PBTK NA 50% Rat Human +DTXSID6047787 Css NA 0.07017 mg/L PBTK NA 95% Rat Human +DTXSID6047789 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047789 Fup 0.739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047789 Vd NA 0.8763 L/kg 1compartment NA NA Human Human DTXSID6047789 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047789 TK.Half.Life NA 2.101 hours 1compartment NA NA Human Human -DTXSID6047789 Css NA 0.2305 mg/L 3compartmentss NA 50% Human Human -DTXSID6047789 Css NA 1.793 mg/L 3compartmentss NA 95% Human Human -DTXSID6047789 Css NA 0.1995 mg/L PBTK NA 50% Human Human -DTXSID6047789 Css NA 1.242 mg/L PBTK NA 95% Human Human -DTXSID6047789 Clint NA 1.558 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047789 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047789 Vd NA 1.028 L/kg 1compartment NA NA Rat Human +DTXSID6047789 TK.Half.Life NA 7.694 hours 1compartment NA NA Human Human +DTXSID6047789 Css NA 0.9888 mg/L 3compartmentss NA 50% Human Human +DTXSID6047789 Css NA 6.556 mg/L 3compartmentss NA 95% Human Human +DTXSID6047789 Css NA 0.8296 mg/L PBTK NA 50% Human Human +DTXSID6047789 Css NA 4.175 mg/L PBTK NA 95% Human Human +DTXSID6047789 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047789 Fup 0.739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047789 Vd NA 0.8917 L/kg 1compartment NA NA Rat Human DTXSID6047789 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047789 TK.Half.Life NA 1.083 hours 1compartment NA NA Rat Human -DTXSID6047789 Css NA 0.09113 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047789 Css NA 0.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047789 Css NA 0.07875 mg/L PBTK NA 50% Rat Human -DTXSID6047789 Css NA 0.374 mg/L PBTK NA 95% Rat Human -DTXSID6047810 Clint NA 4.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047810 Fup NA 0.1341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047810 Vd NA 1.58 L/kg 1compartment NA NA Human Human +DTXSID6047789 TK.Half.Life NA 2.662 hours 1compartment NA NA Rat Human +DTXSID6047789 Css NA 0.05894 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047789 Css NA 0.3687 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047789 Css NA 0.04959 mg/L PBTK NA 50% Rat Human +DTXSID6047789 Css NA 0.2289 mg/L PBTK NA 95% Rat Human +DTXSID6047810 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047810 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047810 Vd NA 4.144 L/kg 1compartment NA NA Human Human DTXSID6047810 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047810 TK.Half.Life NA 8.768 hours 1compartment NA NA Human Human -DTXSID6047810 Css NA 0.6694 mg/L 3compartmentss NA 50% Human Human -DTXSID6047810 Css NA 4.655 mg/L 3compartmentss NA 95% Human Human -DTXSID6047810 Css NA 0.5063 mg/L PBTK NA 50% Human Human -DTXSID6047810 Css NA 3.081 mg/L PBTK NA 95% Human Human -DTXSID6047810 Clint NA 4.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047810 Fup NA 0.1341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047810 Vd NA 1.551 L/kg 1compartment NA NA Rat Human +DTXSID6047810 TK.Half.Life NA 2.792 hours 1compartment NA NA Human Human +DTXSID6047810 Css NA 0.02092 mg/L 3compartmentss NA 50% Human Human +DTXSID6047810 Css NA 0.2764 mg/L 3compartmentss NA 95% Human Human +DTXSID6047810 Css NA 0.0272 mg/L PBTK NA 50% Human Human +DTXSID6047810 Css NA 0.25 mg/L PBTK NA 95% Human Human +DTXSID6047810 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047810 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047810 Vd NA 4.172 L/kg 1compartment NA NA Rat Human DTXSID6047810 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047810 TK.Half.Life NA 5.115 hours 1compartment NA NA Rat Human -DTXSID6047810 Css NA 0.3372 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047810 Css NA 1.866 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047810 Css NA 0.2454 mg/L PBTK NA 50% Rat Human -DTXSID6047810 Css NA 1.129 mg/L PBTK NA 95% Rat Human -DTXSID6047818 Clint NA 4.383 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047818 Fup NA 0.1637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047818 Vd NA 2.72 L/kg 1compartment NA NA Human Human +DTXSID6047810 TK.Half.Life NA 1.438 hours 1compartment NA NA Rat Human +DTXSID6047810 Css NA 0.002482 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047810 Css NA 0.02731 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047810 Css NA 0.003394 mg/L PBTK NA 50% Rat Human +DTXSID6047810 Css NA 0.02382 mg/L PBTK NA 95% Rat Human +DTXSID6047818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047818 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6047818 Vd NA 1.151 L/kg 1compartment NA NA Human Human DTXSID6047818 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6047818 TK.Half.Life NA 12.19 hours 1compartment NA NA Human Human -DTXSID6047818 Css NA 0.3824 mg/L 3compartmentss NA 50% Human Human -DTXSID6047818 Css NA 2.632 mg/L 3compartmentss NA 95% Human Human -DTXSID6047818 Css NA 0.3679 mg/L PBTK NA 50% Human Human -DTXSID6047818 Css NA 2.048 mg/L PBTK NA 95% Human Human -DTXSID6047818 Clint NA 4.383 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047818 Fup NA 0.1637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047818 Vd NA 2.717 L/kg 1compartment NA NA Rat Human +DTXSID6047818 TK.Half.Life NA 1.539 hours 1compartment NA NA Human Human +DTXSID6047818 Css NA 0.07146 mg/L 3compartmentss NA 50% Human Human +DTXSID6047818 Css NA 0.5434 mg/L 3compartmentss NA 95% Human Human +DTXSID6047818 Css NA 0.05504 mg/L PBTK NA 50% Human Human +DTXSID6047818 Css NA 0.3775 mg/L PBTK NA 95% Human Human +DTXSID6047818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047818 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6047818 Vd NA 1.153 L/kg 1compartment NA NA Rat Human DTXSID6047818 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047818 TK.Half.Life NA 7.167 hours 1compartment NA NA Rat Human -DTXSID6047818 Css NA 0.1936 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047818 Css NA 1.03 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047818 Css NA 0.1824 mg/L PBTK NA 50% Rat Human -DTXSID6047818 Css NA 0.7342 mg/L PBTK NA 95% Rat Human -DTXSID6047947 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047947 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6047947 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID6047947 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6047947 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID6047947 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID6047947 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID6047947 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID6047947 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID6047947 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047947 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6047947 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID6047947 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6047947 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID6047947 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID6047947 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID6047947 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID6047947 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID6048171 Clint NA 14.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048171 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048171 Vd NA 7.749 L/kg 1compartment NA NA Human Human -DTXSID6048171 Days.Css NA 73 Days PBTK NA NA Human Human -DTXSID6048171 TK.Half.Life NA 339.9 hours 1compartment NA NA Human Human -DTXSID6048171 Css NA 3.566 mg/L 3compartmentss NA 50% Human Human -DTXSID6048171 Css NA 20.97 mg/L 3compartmentss NA 95% Human Human -DTXSID6048171 Css NA 3.594 mg/L PBTK NA 50% Human Human -DTXSID6048171 Css NA 20.24 mg/L PBTK NA 95% Human Human -DTXSID6048171 Clint NA 14.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048171 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048171 Vd NA 6.032 L/kg 1compartment NA NA Rat Human -DTXSID6048171 Days.Css NA 42 Days PBTK NA NA Rat Human -DTXSID6048171 TK.Half.Life NA 48.2 hours 1compartment NA NA Rat Human -DTXSID6048171 Css NA 1.967 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048171 Css NA 8.649 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048171 Css NA 1.965 mg/L PBTK NA 50% Rat Human -DTXSID6048171 Css NA 8.576 mg/L PBTK NA 95% Rat Human -DTXSID6048175 Clint NA 16.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048175 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048175 Vd NA 2.049 L/kg 1compartment NA NA Human Human -DTXSID6048175 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6048175 TK.Half.Life NA 22.99 hours 1compartment NA NA Human Human -DTXSID6048175 Css NA 1.708 mg/L 3compartmentss NA 50% Human Human -DTXSID6048175 Css NA 12.9 mg/L 3compartmentss NA 95% Human Human -DTXSID6048175 Css NA 1.106 mg/L PBTK NA 50% Human Human -DTXSID6048175 Css NA 7.98 mg/L PBTK NA 95% Human Human -DTXSID6048175 Clint NA 16.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048175 Fup NA 0.0251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048175 Vd NA 1.526 L/kg 1compartment NA NA Rat Human -DTXSID6048175 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6048175 TK.Half.Life NA 7.225 hours 1compartment NA NA Rat Human -DTXSID6048175 Css NA 0.9419 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048175 Css NA 5.717 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048175 Css NA 0.5732 mg/L PBTK NA 50% Rat Human -DTXSID6048175 Css NA 3.296 mg/L PBTK NA 95% Rat Human -DTXSID6048200 Clint NA 0.3881 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048200 Fup NA 0.0431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048200 Vd NA 0.2752 L/kg 1compartment NA NA Human Human -DTXSID6048200 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6048200 TK.Half.Life NA 25.2 hours 1compartment NA NA Human Human -DTXSID6048200 Css NA 15.12 mg/L 3compartmentss NA 50% Human Human -DTXSID6048200 Css NA 70.59 mg/L 3compartmentss NA 95% Human Human -DTXSID6048200 Css NA 9.162 mg/L PBTK NA 50% Human Human -DTXSID6048200 Css NA 41.13 mg/L PBTK NA 95% Human Human -DTXSID6048200 Clint NA 0.3881 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048200 Fup NA 0.0431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048200 Vd NA 0.2689 L/kg 1compartment NA NA Rat Human -DTXSID6048200 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6048200 TK.Half.Life NA 10.49 hours 1compartment NA NA Rat Human -DTXSID6048200 Css NA 5.462 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048200 Css NA 21.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048200 Css NA 3.101 mg/L PBTK NA 50% Rat Human -DTXSID6048200 Css NA 11.64 mg/L PBTK NA 95% Rat Human -DTXSID6048204 Clint NA 0.8339 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048204 Fup NA 0.1742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048204 Vd NA 2.446 L/kg 1compartment NA NA Human Human -DTXSID6048204 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID6048204 TK.Half.Life NA 89.14 hours 1compartment NA NA Human Human -DTXSID6048204 Css NA 4.227 mg/L 3compartmentss NA 50% Human Human -DTXSID6048204 Css NA 14.98 mg/L 3compartmentss NA 95% Human Human -DTXSID6048204 Css NA 3.044 mg/L PBTK NA 50% Human Human -DTXSID6048204 Css NA 9.972 mg/L PBTK NA 95% Human Human -DTXSID6048204 Clint NA 0.8339 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048204 Fup NA 0.1742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048204 Vd NA 1.86 L/kg 1compartment NA NA Rat Human -DTXSID6048204 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID6048204 TK.Half.Life NA 17.81 hours 1compartment NA NA Rat Human -DTXSID6048204 Css NA 1.72 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048204 Css NA 4.426 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048204 Css NA 1.188 mg/L PBTK NA 50% Rat Human -DTXSID6048204 Css NA 2.735 mg/L PBTK NA 95% Rat Human -DTXSID6048208 Clint NA 85.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048208 Fup NA 0.3196 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048208 Vd NA 2.367 L/kg 1compartment NA NA Human Human +DTXSID6047818 TK.Half.Life NA 0.8431 hours 1compartment NA NA Rat Human +DTXSID6047818 Css NA 0.009062 mg/L 3compartmentss NA 50% Rat Human +DTXSID6047818 Css NA 0.05194 mg/L 3compartmentss NA 95% Rat Human +DTXSID6047818 Css NA 0.006945 mg/L PBTK NA 50% Rat Human +DTXSID6047818 Css NA 0.0349 mg/L PBTK NA 95% Rat Human +DTXSID6048171 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048171 Fup 0.0117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048171 Vd NA 3.061 L/kg 1compartment NA NA Human Human +DTXSID6048171 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID6048171 TK.Half.Life NA 80.82 hours 1compartment NA NA Human Human +DTXSID6048171 Css NA 3.205 mg/L 3compartmentss NA 50% Human Human +DTXSID6048171 Css NA 21.2 mg/L 3compartmentss NA 95% Human Human +DTXSID6048171 Css NA 2.218 mg/L PBTK NA 50% Human Human +DTXSID6048171 Css NA 14.2 mg/L PBTK NA 95% Human Human +DTXSID6048171 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048171 Fup 0.0117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048171 Vd NA 2.293 L/kg 1compartment NA NA Rat Human +DTXSID6048171 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID6048171 TK.Half.Life NA 11.8 hours 1compartment NA NA Rat Human +DTXSID6048171 Css NA 0.4189 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048171 Css NA 2.39 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048171 Css NA 0.285 mg/L PBTK NA 50% Rat Human +DTXSID6048171 Css NA 1.6 mg/L PBTK NA 95% Rat Human +DTXSID6048175 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048175 Fup 0.0263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048175 Vd NA 2.604 L/kg 1compartment NA NA Human Human +DTXSID6048175 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID6048175 TK.Half.Life NA 95.15 hours 1compartment NA NA Human Human +DTXSID6048175 Css NA 5.193 mg/L 3compartmentss NA 50% Human Human +DTXSID6048175 Css NA 32.87 mg/L 3compartmentss NA 95% Human Human +DTXSID6048175 Css NA 3.479 mg/L PBTK NA 50% Human Human +DTXSID6048175 Css NA 21.19 mg/L PBTK NA 95% Human Human +DTXSID6048175 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048175 Fup 0.0263 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048175 Vd NA 1.945 L/kg 1compartment NA NA Rat Human +DTXSID6048175 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID6048175 TK.Half.Life NA 20.97 hours 1compartment NA NA Rat Human +DTXSID6048175 Css NA 0.6473 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048175 Css NA 3.203 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048175 Css NA 0.4239 mg/L PBTK NA 50% Rat Human +DTXSID6048175 Css NA 2.024 mg/L PBTK NA 95% Rat Human +DTXSID6048200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048200 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048200 Vd NA 0.4218 L/kg 1compartment NA NA Human Human +DTXSID6048200 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048200 TK.Half.Life NA 0.9742 hours 1compartment NA NA Human Human +DTXSID6048200 Css NA 0.2319 mg/L 3compartmentss NA 50% Human Human +DTXSID6048200 Css NA 1.96 mg/L 3compartmentss NA 95% Human Human +DTXSID6048200 Css NA 0.1517 mg/L PBTK NA 50% Human Human +DTXSID6048200 Css NA 1.203 mg/L PBTK NA 95% Human Human +DTXSID6048200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048200 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048200 Vd NA 0.4144 L/kg 1compartment NA NA Rat Human +DTXSID6048200 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048200 TK.Half.Life NA 0.564 hours 1compartment NA NA Rat Human +DTXSID6048200 Css NA 0.03012 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048200 Css NA 0.1964 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048200 Css NA 0.01926 mg/L PBTK NA 50% Rat Human +DTXSID6048200 Css NA 0.1183 mg/L PBTK NA 95% Rat Human +DTXSID6048202 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048202 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048202 Vd NA 1.631 L/kg 1compartment NA NA Human Human +DTXSID6048202 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048202 TK.Half.Life NA 4.266 hours 1compartment NA NA Human Human +DTXSID6048202 Css NA 0.2666 mg/L 3compartmentss NA 50% Human Human +DTXSID6048202 Css NA 2.054 mg/L 3compartmentss NA 95% Human Human +DTXSID6048202 Css NA 0.1794 mg/L PBTK NA 50% Human Human +DTXSID6048202 Css NA 1.31 mg/L PBTK NA 95% Human Human +DTXSID6048202 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048202 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048202 Vd NA 1.25 L/kg 1compartment NA NA Rat Human +DTXSID6048202 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048202 TK.Half.Life NA 1.599 hours 1compartment NA NA Rat Human +DTXSID6048202 Css NA 0.03426 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048202 Css NA 0.2023 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048202 Css NA 0.02264 mg/L PBTK NA 50% Rat Human +DTXSID6048202 Css NA 0.1256 mg/L PBTK NA 95% Rat Human +DTXSID6048204 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048204 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048204 Vd NA 2.708 L/kg 1compartment NA NA Human Human +DTXSID6048204 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048204 TK.Half.Life NA 9.731 hours 1compartment NA NA Human Human +DTXSID6048204 Css NA 0.3347 mg/L 3compartmentss NA 50% Human Human +DTXSID6048204 Css NA 2.061 mg/L 3compartmentss NA 95% Human Human +DTXSID6048204 Css NA 0.2404 mg/L PBTK NA 50% Human Human +DTXSID6048204 Css NA 1.412 mg/L PBTK NA 95% Human Human +DTXSID6048204 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048204 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048204 Vd NA 2.051 L/kg 1compartment NA NA Rat Human +DTXSID6048204 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048204 TK.Half.Life NA 2.328 hours 1compartment NA NA Rat Human +DTXSID6048204 Css NA 0.04286 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048204 Css NA 0.2088 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048204 Css NA 0.03052 mg/L PBTK NA 50% Rat Human +DTXSID6048204 Css NA 0.1462 mg/L PBTK NA 95% Rat Human +DTXSID6048208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048208 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048208 Vd NA 1.733 L/kg 1compartment NA NA Human Human DTXSID6048208 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048208 TK.Half.Life NA 2.345 hours 1compartment NA NA Human Human -DTXSID6048208 Css NA 0.03225 mg/L 3compartmentss NA 50% Human Human -DTXSID6048208 Css NA 0.2156 mg/L 3compartmentss NA 95% Human Human -DTXSID6048208 Css NA 0.02462 mg/L PBTK NA 50% Human Human -DTXSID6048208 Css NA 0.1505 mg/L PBTK NA 95% Human Human -DTXSID6048208 Clint NA 85.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048208 Fup NA 0.3196 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048208 Vd NA 1.832 L/kg 1compartment NA NA Rat Human +DTXSID6048208 TK.Half.Life NA 4.335 hours 1compartment NA NA Human Human +DTXSID6048208 Css NA 0.2438 mg/L 3compartmentss NA 50% Human Human +DTXSID6048208 Css NA 1.847 mg/L 3compartmentss NA 95% Human Human +DTXSID6048208 Css NA 0.1666 mg/L PBTK NA 50% Human Human +DTXSID6048208 Css NA 1.203 mg/L PBTK NA 95% Human Human +DTXSID6048208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048208 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048208 Vd NA 1.33 L/kg 1compartment NA NA Rat Human DTXSID6048208 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048208 TK.Half.Life NA 0.7568 hours 1compartment NA NA Rat Human -DTXSID6048208 Css NA 0.01764 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048208 Css NA 0.104 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048208 Css NA 0.01297 mg/L PBTK NA 50% Rat Human -DTXSID6048208 Css NA 0.07084 mg/L PBTK NA 95% Rat Human +DTXSID6048208 TK.Half.Life NA 1.584 hours 1compartment NA NA Rat Human +DTXSID6048208 Css NA 0.03084 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048208 Css NA 0.1848 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048208 Css NA 0.02072 mg/L PBTK NA 50% Rat Human +DTXSID6048208 Css NA 0.1178 mg/L PBTK NA 95% Rat Human DTXSID6048333 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6048333 Fup NA 0.4345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048333 Vd NA 2.858 L/kg 1compartment NA NA Human Human -DTXSID6048333 Days.Css NA 47 Days PBTK NA NA Human Human -DTXSID6048333 TK.Half.Life NA 223.5 hours 1compartment NA NA Human Human -DTXSID6048333 Css NA 8.038 mg/L 3compartmentss NA 50% Human Human -DTXSID6048333 Css NA 23.96 mg/L 3compartmentss NA 95% Human Human -DTXSID6048333 Css NA 6.386 mg/L PBTK NA 50% Human Human -DTXSID6048333 Css NA 17.01 mg/L PBTK NA 95% Human Human +DTXSID6048333 Vd NA 0.534 L/kg 1compartment NA NA Human Human +DTXSID6048333 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048333 TK.Half.Life NA 8.001 hours 1compartment NA NA Human Human +DTXSID6048333 Css NA 1.439 mg/L 3compartmentss NA 50% Human Human +DTXSID6048333 Css NA 6.787 mg/L 3compartmentss NA 95% Human Human +DTXSID6048333 Css NA 1.072 mg/L PBTK NA 50% Human Human +DTXSID6048333 Css NA 4.316 mg/L PBTK NA 95% Human Human DTXSID6048333 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6048333 Fup NA 0.4345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048333 Vd NA 2.193 L/kg 1compartment NA NA Rat Human -DTXSID6048333 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID6048333 TK.Half.Life NA 22.41 hours 1compartment NA NA Rat Human -DTXSID6048333 Css NA 2.152 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048333 Css NA 5.271 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048333 Css NA 1.658 mg/L PBTK NA 50% Rat Human -DTXSID6048333 Css NA 3.433 mg/L PBTK NA 95% Rat Human -DTXSID6048383 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048383 Fup NA 0.4043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048383 Vd NA 1.487 L/kg 1compartment NA NA Human Human -DTXSID6048383 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6048383 TK.Half.Life NA 29.33 hours 1compartment NA NA Human Human -DTXSID6048383 Css NA 2.06 mg/L 3compartmentss NA 50% Human Human -DTXSID6048383 Css NA 8.509 mg/L 3compartmentss NA 95% Human Human -DTXSID6048383 Css NA 1.655 mg/L PBTK NA 50% Human Human -DTXSID6048383 Css NA 5.675 mg/L PBTK NA 95% Human Human -DTXSID6048383 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048383 Fup NA 0.4043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048383 Vd NA 1.241 L/kg 1compartment NA NA Rat Human +DTXSID6048333 Vd NA 0.5208 L/kg 1compartment NA NA Rat Human +DTXSID6048333 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048333 TK.Half.Life NA 2.647 hours 1compartment NA NA Rat Human +DTXSID6048333 Css NA 0.0349 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048333 Css NA 0.2105 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048333 Css NA 0.0258 mg/L PBTK NA 50% Rat Human +DTXSID6048333 Css NA 0.1344 mg/L PBTK NA 95% Rat Human +DTXSID6048337 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048337 Fup 0.33 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6048337 Vd NA 5.573 L/kg 1compartment NA NA Human Human +DTXSID6048337 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048337 TK.Half.Life NA 4.469 hours 1compartment NA NA Human Human +DTXSID6048337 Css NA 0.02566 mg/L 3compartmentss NA 50% Human Human +DTXSID6048337 Css NA 0.2351 mg/L 3compartmentss NA 95% Human Human +DTXSID6048337 Css NA 0.0369 mg/L PBTK NA 50% Human Human +DTXSID6048337 Css NA 0.2659 mg/L PBTK NA 95% Human Human +DTXSID6048337 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048337 Fup 0.33 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6048337 Vd NA 5.482 L/kg 1compartment NA NA Rat Human +DTXSID6048337 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048337 TK.Half.Life NA 2.046 hours 1compartment NA NA Rat Human +DTXSID6048337 Css NA 0.003142 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048337 Css NA 0.02141 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048337 Css NA 0.004836 mg/L PBTK NA 50% Rat Human +DTXSID6048337 Css NA 0.02498 mg/L PBTK NA 95% Rat Human +DTXSID6048339 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048339 Fup 0.54 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6048339 Vd NA 3.745 L/kg 1compartment NA NA Human Human +DTXSID6048339 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048339 TK.Half.Life NA 7.551 hours 1compartment NA NA Human Human +DTXSID6048339 Css NA 0.1375 mg/L 3compartmentss NA 50% Human Human +DTXSID6048339 Css NA 0.9492 mg/L 3compartmentss NA 95% Human Human +DTXSID6048339 Css NA 0.1209 mg/L PBTK NA 50% Human Human +DTXSID6048339 Css NA 0.7607 mg/L PBTK NA 95% Human Human +DTXSID6048339 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048339 Fup 0.54 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6048339 Vd NA 3.126 L/kg 1compartment NA NA Rat Human +DTXSID6048339 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048339 TK.Half.Life NA 1.85 hours 1compartment NA NA Rat Human +DTXSID6048339 Css NA 0.01736 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048339 Css NA 0.09376 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048339 Css NA 0.01533 mg/L PBTK NA 50% Rat Human +DTXSID6048339 Css NA 0.07827 mg/L PBTK NA 95% Rat Human +DTXSID6048383 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048383 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048383 Vd NA 2.062 L/kg 1compartment NA NA Human Human +DTXSID6048383 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048383 TK.Half.Life NA 2.758 hours 1compartment NA NA Human Human +DTXSID6048383 Css NA 0.07346 mg/L 3compartmentss NA 50% Human Human +DTXSID6048383 Css NA 0.5287 mg/L 3compartmentss NA 95% Human Human +DTXSID6048383 Css NA 0.0583 mg/L PBTK NA 50% Human Human +DTXSID6048383 Css NA 0.3855 mg/L PBTK NA 95% Human Human +DTXSID6048383 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048383 Fup 0.386 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048383 Vd NA 1.639 L/kg 1compartment NA NA Rat Human DTXSID6048383 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048383 TK.Half.Life NA 7.144 hours 1compartment NA NA Rat Human -DTXSID6048383 Css NA 0.5521 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048383 Css NA 1.992 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048383 Css NA 0.4285 mg/L PBTK NA 50% Rat Human -DTXSID6048383 Css NA 1.239 mg/L PBTK NA 95% Rat Human -DTXSID6048591 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048591 Fup NA 0.4407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048591 Vd NA 0.5788 L/kg 1compartment NA NA Human Human +DTXSID6048383 TK.Half.Life NA 0.9685 hours 1compartment NA NA Rat Human +DTXSID6048383 Css NA 0.008975 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048383 Css NA 0.05125 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048383 Css NA 0.007195 mg/L PBTK NA 50% Rat Human +DTXSID6048383 Css NA 0.03654 mg/L PBTK NA 95% Rat Human +DTXSID6048385 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID6048385 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6048385 Vd NA 2.9 L/kg 1compartment NA NA Human Human +DTXSID6048385 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID6048385 TK.Half.Life NA 84.07 hours 1compartment NA NA Human Human +DTXSID6048385 Css NA 3.722 mg/L 3compartmentss NA 50% Human Human +DTXSID6048385 Css NA 23.99 mg/L 3compartmentss NA 95% Human Human +DTXSID6048385 Css NA 2.539 mg/L PBTK NA 50% Human Human +DTXSID6048385 Css NA 16.01 mg/L PBTK NA 95% Human Human +DTXSID6048385 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID6048385 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6048385 Vd NA 2.173 L/kg 1compartment NA NA Rat Human +DTXSID6048385 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID6048385 TK.Half.Life NA 14.6 hours 1compartment NA NA Rat Human +DTXSID6048385 Css NA 0.4676 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048385 Css NA 2.397 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048385 Css NA 0.3151 mg/L PBTK NA 50% Rat Human +DTXSID6048385 Css NA 1.57 mg/L PBTK NA 95% Rat Human +DTXSID6048414 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048414 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6048414 Vd NA 4.056 L/kg 1compartment NA NA Human Human +DTXSID6048414 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048414 TK.Half.Life NA 3.677 hours 1compartment NA NA Human Human +DTXSID6048414 Css NA 0.04152 mg/L 3compartmentss NA 50% Human Human +DTXSID6048414 Css NA 0.3175 mg/L 3compartmentss NA 95% Human Human +DTXSID6048414 Css NA 0.05496 mg/L PBTK NA 50% Human Human +DTXSID6048414 Css NA 0.323 mg/L PBTK NA 95% Human Human +DTXSID6048414 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048414 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6048414 Vd NA 4.214 L/kg 1compartment NA NA Rat Human +DTXSID6048414 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048414 TK.Half.Life NA 2.053 hours 1compartment NA NA Rat Human +DTXSID6048414 Css NA 0.001894 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048414 Css NA 0.02162 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048414 Css NA 0.002606 mg/L PBTK NA 50% Rat Human +DTXSID6048414 Css NA 0.02048 mg/L PBTK NA 95% Rat Human +DTXSID6048462 Clint 7 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID6048462 Fup 0.086 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6048462 Vd NA 1.45 L/kg 1compartment NA NA Human Human +DTXSID6048462 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048462 TK.Half.Life NA 9.428 hours 1compartment NA NA Human Human +DTXSID6048462 Css NA 0.8547 mg/L 3compartmentss NA 50% Human Human +DTXSID6048462 Css NA 6.237 mg/L 3compartmentss NA 95% Human Human +DTXSID6048462 Css NA 0.5922 mg/L PBTK NA 50% Human Human +DTXSID6048462 Css NA 3.941 mg/L PBTK NA 95% Human Human +DTXSID6048462 Clint 7 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID6048462 Fup 0.086 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6048462 Vd NA 1.29 L/kg 1compartment NA NA Rat Human +DTXSID6048462 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048462 TK.Half.Life NA 4.837 hours 1compartment NA NA Rat Human +DTXSID6048462 Css NA 0.1063 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048462 Css NA 0.5819 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048462 Css NA 0.07218 mg/L PBTK NA 50% Rat Human +DTXSID6048462 Css NA 0.3547 mg/L PBTK NA 95% Rat Human +DTXSID6048464 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048464 Fup 0.52 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6048464 Vd NA 0.4755 L/kg 1compartment NA NA Human Human +DTXSID6048464 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048464 TK.Half.Life NA 0.8076 hours 1compartment NA NA Human Human +DTXSID6048464 Css NA 0.06499 mg/L 3compartmentss NA 50% Human Human +DTXSID6048464 Css NA 0.5922 mg/L 3compartmentss NA 95% Human Human +DTXSID6048464 Css NA 0.04755 mg/L PBTK NA 50% Human Human +DTXSID6048464 Css NA 0.3856 mg/L PBTK NA 95% Human Human +DTXSID6048464 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048464 Fup 0.52 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6048464 Vd NA 0.479 L/kg 1compartment NA NA Rat Human +DTXSID6048464 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048464 TK.Half.Life NA 0.4421 hours 1compartment NA NA Rat Human +DTXSID6048464 Css NA 0.0006086 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048464 Css NA 0.004928 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048464 Css NA 0.0004298 mg/L PBTK NA 50% Rat Human +DTXSID6048464 Css NA 0.002986 mg/L PBTK NA 95% Rat Human +DTXSID6048543 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048543 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6048543 Vd NA 6.253 L/kg 1compartment NA NA Human Human +DTXSID6048543 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048543 TK.Half.Life NA 4.674 hours 1compartment NA NA Human Human +DTXSID6048543 Css NA 0.0246 mg/L 3compartmentss NA 50% Human Human +DTXSID6048543 Css NA 0.2452 mg/L 3compartmentss NA 95% Human Human +DTXSID6048543 Css NA 0.03618 mg/L PBTK NA 50% Human Human +DTXSID6048543 Css NA 0.2792 mg/L PBTK NA 95% Human Human +DTXSID6048543 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048543 Fup 0.73 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6048543 Vd NA 6.027 L/kg 1compartment NA NA Rat Human +DTXSID6048543 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048543 TK.Half.Life NA 1.721 hours 1compartment NA NA Rat Human +DTXSID6048543 Css NA 0.002968 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048543 Css NA 0.02282 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048543 Css NA 0.004642 mg/L PBTK NA 50% Rat Human +DTXSID6048543 Css NA 0.02778 mg/L PBTK NA 95% Rat Human +DTXSID6048549 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID6048549 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID6048549 Vd NA 0.5722 L/kg 1compartment NA NA Human Human +DTXSID6048549 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048549 TK.Half.Life NA 6.43 hours 1compartment NA NA Human Human +DTXSID6048549 Css NA 1.566 mg/L 3compartmentss NA 50% Human Human +DTXSID6048549 Css NA 9.167 mg/L 3compartmentss NA 95% Human Human +DTXSID6048549 Css NA 1.012 mg/L PBTK NA 50% Human Human +DTXSID6048549 Css NA 5.545 mg/L PBTK NA 95% Human Human +DTXSID6048549 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID6048549 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID6048549 Vd NA 0.5036 L/kg 1compartment NA NA Rat Human +DTXSID6048549 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048549 TK.Half.Life NA 3.072 hours 1compartment NA NA Rat Human +DTXSID6048549 Css NA 0.1671 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048549 Css NA 0.7188 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048549 Css NA 0.1056 mg/L PBTK NA 50% Rat Human +DTXSID6048549 Css NA 0.4183 mg/L PBTK NA 95% Rat Human +DTXSID6048591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048591 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048591 Vd NA 0.3394 L/kg 1compartment NA NA Human Human DTXSID6048591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048591 TK.Half.Life NA 8.507 hours 1compartment NA NA Human Human -DTXSID6048591 Css NA 1.644 mg/L 3compartmentss NA 50% Human Human -DTXSID6048591 Css NA 7.534 mg/L 3compartmentss NA 95% Human Human -DTXSID6048591 Css NA 1.227 mg/L PBTK NA 50% Human Human -DTXSID6048591 Css NA 4.83 mg/L PBTK NA 95% Human Human -DTXSID6048591 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048591 Fup NA 0.4407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048591 Vd NA 0.5912 L/kg 1compartment NA NA Rat Human +DTXSID6048591 TK.Half.Life NA 5.394 hours 1compartment NA NA Human Human +DTXSID6048591 Css NA 1.035 mg/L 3compartmentss NA 50% Human Human +DTXSID6048591 Css NA 4.656 mg/L 3compartmentss NA 95% Human Human +DTXSID6048591 Css NA 0.7012 mg/L PBTK NA 50% Human Human +DTXSID6048591 Css NA 2.897 mg/L PBTK NA 95% Human Human +DTXSID6048591 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048591 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048591 Vd NA 0.3504 L/kg 1compartment NA NA Rat Human DTXSID6048591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048591 TK.Half.Life NA 2.958 hours 1compartment NA NA Rat Human -DTXSID6048591 Css NA 0.4526 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048591 Css NA 1.765 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048591 Css NA 0.3208 mg/L PBTK NA 50% Rat Human -DTXSID6048591 Css NA 1.044 mg/L PBTK NA 95% Rat Human -DTXSID6048593 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048593 Fup NA 0.7945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048593 Vd NA 0.6184 L/kg 1compartment NA NA Human Human +DTXSID6048591 TK.Half.Life NA 1.897 hours 1compartment NA NA Rat Human +DTXSID6048591 Css NA 0.00566 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048591 Css NA 0.02648 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048591 Css NA 0.003643 mg/L PBTK NA 50% Rat Human +DTXSID6048591 Css NA 0.01551 mg/L PBTK NA 95% Rat Human +DTXSID6048593 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048593 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048593 Vd NA 0.3654 L/kg 1compartment NA NA Human Human DTXSID6048593 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048593 TK.Half.Life NA 5.037 hours 1compartment NA NA Human Human -DTXSID6048593 Css NA 1.016 mg/L 3compartmentss NA 50% Human Human -DTXSID6048593 Css NA 5.913 mg/L 3compartmentss NA 95% Human Human -DTXSID6048593 Css NA 0.8111 mg/L PBTK NA 50% Human Human -DTXSID6048593 Css NA 3.774 mg/L PBTK NA 95% Human Human -DTXSID6048593 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048593 Fup NA 0.7945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048593 Vd NA 0.6589 L/kg 1compartment NA NA Rat Human +DTXSID6048593 TK.Half.Life NA 1.149 hours 1compartment NA NA Human Human +DTXSID6048593 Css NA 0.1604 mg/L 3compartmentss NA 50% Human Human +DTXSID6048593 Css NA 1.095 mg/L 3compartmentss NA 95% Human Human +DTXSID6048593 Css NA 0.1065 mg/L PBTK NA 50% Human Human +DTXSID6048593 Css NA 0.6826 mg/L PBTK NA 95% Human Human +DTXSID6048593 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048593 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048593 Vd NA 0.376 L/kg 1compartment NA NA Rat Human DTXSID6048593 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048593 TK.Half.Life NA 1.828 hours 1compartment NA NA Rat Human -DTXSID6048593 Css NA 0.2636 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048593 Css NA 1.566 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048593 Css NA 0.2032 mg/L PBTK NA 50% Rat Human -DTXSID6048593 Css NA 0.9249 mg/L PBTK NA 95% Rat Human -DTXSID6048595 Clint NA 106.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048595 Fup NA 0.2679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048595 Vd NA 3.231 L/kg 1compartment NA NA Human Human +DTXSID6048593 TK.Half.Life NA 0.6863 hours 1compartment NA NA Rat Human +DTXSID6048593 Css NA 0.001554 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048593 Css NA 0.008629 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048593 Css NA 0.0009764 mg/L PBTK NA 50% Rat Human +DTXSID6048593 Css NA 0.005066 mg/L PBTK NA 95% Rat Human +DTXSID6048595 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048595 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048595 Vd NA 2.545 L/kg 1compartment NA NA Human Human DTXSID6048595 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048595 TK.Half.Life NA 2.229 hours 1compartment NA NA Human Human -DTXSID6048595 Css NA 0.01365 mg/L 3compartmentss NA 50% Human Human -DTXSID6048595 Css NA 0.1096 mg/L 3compartmentss NA 95% Human Human -DTXSID6048595 Css NA 0.01359 mg/L PBTK NA 50% Human Human -DTXSID6048595 Css NA 0.09129 mg/L PBTK NA 95% Human Human -DTXSID6048595 Clint NA 106.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048595 Fup NA 0.2679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048595 Vd NA 3.039 L/kg 1compartment NA NA Rat Human +DTXSID6048595 TK.Half.Life NA 3.605 hours 1compartment NA NA Human Human +DTXSID6048595 Css NA 0.08911 mg/L 3compartmentss NA 50% Human Human +DTXSID6048595 Css NA 0.9151 mg/L 3compartmentss NA 95% Human Human +DTXSID6048595 Css NA 0.09298 mg/L PBTK NA 50% Human Human +DTXSID6048595 Css NA 0.6962 mg/L PBTK NA 95% Human Human +DTXSID6048595 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048595 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048595 Vd NA 2.572 L/kg 1compartment NA NA Rat Human DTXSID6048595 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048595 TK.Half.Life NA 0.9606 hours 1compartment NA NA Rat Human -DTXSID6048595 Css NA 0.007329 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048595 Css NA 0.04653 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048595 Css NA 0.007216 mg/L PBTK NA 50% Rat Human -DTXSID6048595 Css NA 0.03945 mg/L PBTK NA 95% Rat Human -DTXSID6048597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048597 Fup NA 0.0785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048597 Vd NA 0.5076 L/kg 1compartment NA NA Human Human -DTXSID6048597 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID6048597 TK.Half.Life NA 42.79 hours 1compartment NA NA Human Human -DTXSID6048597 Css NA 13.43 mg/L 3compartmentss NA 50% Human Human -DTXSID6048597 Css NA 59.23 mg/L 3compartmentss NA 95% Human Human -DTXSID6048597 Css NA 8.317 mg/L PBTK NA 50% Human Human -DTXSID6048597 Css NA 34.94 mg/L PBTK NA 95% Human Human -DTXSID6048597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048597 Fup NA 0.0785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048597 Vd NA 0.4379 L/kg 1compartment NA NA Rat Human -DTXSID6048597 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6048597 TK.Half.Life NA 12.36 hours 1compartment NA NA Rat Human -DTXSID6048597 Css NA 3.753 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048597 Css NA 14.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048597 Css NA 2.178 mg/L PBTK NA 50% Rat Human -DTXSID6048597 Css NA 7.955 mg/L PBTK NA 95% Rat Human +DTXSID6048595 TK.Half.Life NA 2.032 hours 1compartment NA NA Rat Human +DTXSID6048595 Css NA 0.009812 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048595 Css NA 0.095 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048595 Css NA 0.01076 mg/L PBTK NA 50% Rat Human +DTXSID6048595 Css NA 0.06664 mg/L PBTK NA 95% Rat Human +DTXSID6048597 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048597 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048597 Vd NA 1.149 L/kg 1compartment NA NA Human Human +DTXSID6048597 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048597 TK.Half.Life NA 2.267 hours 1compartment NA NA Human Human +DTXSID6048597 Css NA 0.1628 mg/L 3compartmentss NA 50% Human Human +DTXSID6048597 Css NA 1.274 mg/L 3compartmentss NA 95% Human Human +DTXSID6048597 Css NA 0.1101 mg/L PBTK NA 50% Human Human +DTXSID6048597 Css NA 0.8107 mg/L PBTK NA 95% Human Human +DTXSID6048597 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048597 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048597 Vd NA 0.9131 L/kg 1compartment NA NA Rat Human +DTXSID6048597 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048597 TK.Half.Life NA 0.954 hours 1compartment NA NA Rat Human +DTXSID6048597 Css NA 0.02108 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048597 Css NA 0.1188 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048597 Css NA 0.01409 mg/L PBTK NA 50% Rat Human +DTXSID6048597 Css NA 0.07439 mg/L PBTK NA 95% Rat Human DTXSID6048599 Clint NA 83.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6048599 Fup NA 0.455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048599 Vd NA 1.381 L/kg 1compartment NA NA Human Human +DTXSID6048599 Vd NA 0.395 L/kg 1compartment NA NA Human Human DTXSID6048599 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048599 TK.Half.Life NA 0.993 hours 1compartment NA NA Human Human -DTXSID6048599 Css NA 0.01094 mg/L 3compartmentss NA 50% Human Human -DTXSID6048599 Css NA 0.1018 mg/L 3compartmentss NA 95% Human Human -DTXSID6048599 Css NA 0.009316 mg/L PBTK NA 50% Human Human -DTXSID6048599 Css NA 0.07413 mg/L PBTK NA 95% Human Human +DTXSID6048599 TK.Half.Life NA 0.3389 hours 1compartment NA NA Human Human +DTXSID6048599 Css NA 0.0074 mg/L 3compartmentss NA 50% Human Human +DTXSID6048599 Css NA 0.08803 mg/L 3compartmentss NA 95% Human Human +DTXSID6048599 Css NA 0.005165 mg/L PBTK NA 50% Human Human +DTXSID6048599 Css NA 0.05754 mg/L PBTK NA 95% Human Human DTXSID6048599 Clint NA 83.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6048599 Fup NA 0.455 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048599 Vd NA 1.352 L/kg 1compartment NA NA Rat Human +DTXSID6048599 Vd NA 0.4021 L/kg 1compartment NA NA Rat Human DTXSID6048599 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048599 TK.Half.Life NA 0.4507 hours 1compartment NA NA Rat Human -DTXSID6048599 Css NA 0.005876 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048599 Css NA 0.04473 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048599 Css NA 0.00488 mg/L PBTK NA 50% Rat Human -DTXSID6048599 Css NA 0.03108 mg/L PBTK NA 95% Rat Human -DTXSID6048620 Clint NA 35.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048620 Fup NA 0.0155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048620 Vd NA 152.3 L/kg 1compartment NA NA Human Human -DTXSID6048620 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID6048620 TK.Half.Life NA 2731 hours 1compartment NA NA Human Human -DTXSID6048620 Css NA 0.07554 mg/L 3compartmentss NA 50% Human Human -DTXSID6048620 Css NA 0.4626 mg/L 3compartmentss NA 95% Human Human -DTXSID6048620 Css NA 1.489 mg/L PBTK NA 50% Human Human -DTXSID6048620 Css NA 8.085 mg/L PBTK NA 95% Human Human -DTXSID6048620 Clint NA 35.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048620 Fup NA 0.0155 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048620 Vd NA 133.4 L/kg 1compartment NA NA Rat Human -DTXSID6048620 Days.Css NA 455 Days PBTK NA NA Rat Human -DTXSID6048620 TK.Half.Life NA 412.3 hours 1compartment NA NA Rat Human -DTXSID6048620 Css NA 0.03856 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048620 Css NA 0.1638 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048620 Css NA 0.8031 mg/L PBTK NA 50% Rat Human -DTXSID6048620 Css NA 3.509 mg/L PBTK NA 95% Rat Human -DTXSID6048622 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048622 Fup NA 0.003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048622 Vd NA 2.044 L/kg 1compartment NA NA Human Human -DTXSID6048622 Days.Css NA 14 Days PBTK NA NA Human Human -DTXSID6048622 TK.Half.Life NA 86.07 hours 1compartment NA NA Human Human -DTXSID6048622 Css NA 7.048 mg/L 3compartmentss NA 50% Human Human -DTXSID6048622 Css NA 53.18 mg/L 3compartmentss NA 95% Human Human -DTXSID6048622 Css NA 4.497 mg/L PBTK NA 50% Human Human -DTXSID6048622 Css NA 32.72 mg/L PBTK NA 95% Human Human -DTXSID6048622 Clint NA 15.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048622 Fup NA 0.003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048622 Vd NA 1.512 L/kg 1compartment NA NA Rat Human -DTXSID6048622 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID6048622 TK.Half.Life NA 32.28 hours 1compartment NA NA Rat Human -DTXSID6048622 Css NA 4.005 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048622 Css NA 24.14 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048622 Css NA 2.402 mg/L PBTK NA 50% Rat Human -DTXSID6048622 Css NA 13.98 mg/L PBTK NA 95% Rat Human -DTXSID6048624 Clint NA 0.3335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048624 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048624 Vd NA 0.3994 L/kg 1compartment NA NA Human Human -DTXSID6048624 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6048624 TK.Half.Life NA 13.58 hours 1compartment NA NA Human Human -DTXSID6048624 Css NA 4.849 mg/L 3compartmentss NA 50% Human Human -DTXSID6048624 Css NA 24.16 mg/L 3compartmentss NA 95% Human Human -DTXSID6048624 Css NA 3.151 mg/L PBTK NA 50% Human Human -DTXSID6048624 Css NA 14.45 mg/L PBTK NA 95% Human Human -DTXSID6048624 Clint NA 0.3335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048624 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048624 Vd NA 0.3942 L/kg 1compartment NA NA Rat Human +DTXSID6048599 TK.Half.Life NA 0.158 hours 1compartment NA NA Rat Human +DTXSID6048599 Css NA 0.0002612 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048599 Css NA 0.003651 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048599 Css NA 0.0001772 mg/L PBTK NA 50% Rat Human +DTXSID6048599 Css NA 0.002296 mg/L PBTK NA 95% Rat Human +DTXSID6048620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048620 Fup 0.0102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048620 Vd NA 12.65 L/kg 1compartment NA NA Human Human +DTXSID6048620 Days.Css NA 81 Days PBTK NA NA Human Human +DTXSID6048620 TK.Half.Life NA 378.4 hours 1compartment NA NA Human Human +DTXSID6048620 Css NA 0.9144 mg/L 3compartmentss NA 50% Human Human +DTXSID6048620 Css NA 6.069 mg/L 3compartmentss NA 95% Human Human +DTXSID6048620 Css NA 1.302 mg/L PBTK NA 50% Human Human +DTXSID6048620 Css NA 8.574 mg/L PBTK NA 95% Human Human +DTXSID6048620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048620 Fup 0.0102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048620 Vd NA 10.06 L/kg 1compartment NA NA Rat Human +DTXSID6048620 Days.Css NA 49 Days PBTK NA NA Rat Human +DTXSID6048620 TK.Half.Life NA 53.48 hours 1compartment NA NA Rat Human +DTXSID6048620 Css NA 0.0095 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048620 Css NA 0.05663 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048620 Css NA 0.0138 mg/L PBTK NA 50% Rat Human +DTXSID6048620 Css NA 0.08113 mg/L PBTK NA 95% Rat Human +DTXSID6048622 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048622 Fup 0.0536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048622 Vd NA 1.526 L/kg 1compartment NA NA Human Human +DTXSID6048622 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048622 TK.Half.Life NA 6.849 hours 1compartment NA NA Human Human +DTXSID6048622 Css NA 0.5178 mg/L 3compartmentss NA 50% Human Human +DTXSID6048622 Css NA 3.992 mg/L 3compartmentss NA 95% Human Human +DTXSID6048622 Css NA 0.3325 mg/L PBTK NA 50% Human Human +DTXSID6048622 Css NA 2.448 mg/L PBTK NA 95% Human Human +DTXSID6048622 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048622 Fup 0.0536 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048622 Vd NA 1.148 L/kg 1compartment NA NA Rat Human +DTXSID6048622 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048622 TK.Half.Life NA 2.621 hours 1compartment NA NA Rat Human +DTXSID6048622 Css NA 0.02546 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048622 Css NA 0.2192 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048622 Css NA 0.01586 mg/L PBTK NA 50% Rat Human +DTXSID6048622 Css NA 0.1282 mg/L PBTK NA 95% Rat Human +DTXSID6048624 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048624 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048624 Vd NA 0.4454 L/kg 1compartment NA NA Human Human +DTXSID6048624 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048624 TK.Half.Life NA 0.6273 hours 1compartment NA NA Human Human +DTXSID6048624 Css NA 0.0782 mg/L 3compartmentss NA 50% Human Human +DTXSID6048624 Css NA 0.5761 mg/L 3compartmentss NA 95% Human Human +DTXSID6048624 Css NA 0.05417 mg/L PBTK NA 50% Human Human +DTXSID6048624 Css NA 0.3715 mg/L PBTK NA 95% Human Human +DTXSID6048624 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048624 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048624 Vd NA 0.4486 L/kg 1compartment NA NA Rat Human DTXSID6048624 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048624 TK.Half.Life NA 5.581 hours 1compartment NA NA Rat Human -DTXSID6048624 Css NA 1.724 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048624 Css NA 7.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048624 Css NA 1.055 mg/L PBTK NA 50% Rat Human -DTXSID6048624 Css NA 3.957 mg/L PBTK NA 95% Rat Human -DTXSID6048626 Clint NA 0.9762 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048626 Fup NA 0.0514 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048626 Vd NA 0.2172 L/kg 1compartment NA NA Human Human -DTXSID6048626 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6048626 TK.Half.Life NA 10.53 hours 1compartment NA NA Human Human -DTXSID6048626 Css NA 8.364 mg/L 3compartmentss NA 50% Human Human -DTXSID6048626 Css NA 43.97 mg/L 3compartmentss NA 95% Human Human -DTXSID6048626 Css NA 4.991 mg/L PBTK NA 50% Human Human -DTXSID6048626 Css NA 25.54 mg/L PBTK NA 95% Human Human -DTXSID6048626 Clint NA 0.9762 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048626 Fup NA 0.0514 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048626 Vd NA 0.2147 L/kg 1compartment NA NA Rat Human +DTXSID6048624 TK.Half.Life NA 0.3403 hours 1compartment NA NA Rat Human +DTXSID6048624 Css NA 0.009993 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048624 Css NA 0.055 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048624 Css NA 0.006822 mg/L PBTK NA 50% Rat Human +DTXSID6048624 Css NA 0.03446 mg/L PBTK NA 95% Rat Human +DTXSID6048626 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048626 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048626 Vd NA 0.3599 L/kg 1compartment NA NA Human Human +DTXSID6048626 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048626 TK.Half.Life NA 1.178 hours 1compartment NA NA Human Human +DTXSID6048626 Css NA 0.3236 mg/L 3compartmentss NA 50% Human Human +DTXSID6048626 Css NA 1.9 mg/L 3compartmentss NA 95% Human Human +DTXSID6048626 Css NA 0.2157 mg/L PBTK NA 50% Human Human +DTXSID6048626 Css NA 1.203 mg/L PBTK NA 95% Human Human +DTXSID6048626 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048626 Fup 0.221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048626 Vd NA 0.3584 L/kg 1compartment NA NA Rat Human DTXSID6048626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048626 TK.Half.Life NA 5.177 hours 1compartment NA NA Rat Human -DTXSID6048626 Css NA 3.455 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048626 Css NA 15.59 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048626 Css NA 1.924 mg/L PBTK NA 50% Rat Human -DTXSID6048626 Css NA 8.471 mg/L PBTK NA 95% Rat Human -DTXSID6048628 Clint NA 13.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048628 Fup NA 0.0807 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048628 Vd NA 2.862 L/kg 1compartment NA NA Human Human -DTXSID6048628 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6048628 TK.Half.Life NA 35.88 hours 1compartment NA NA Human Human -DTXSID6048628 Css NA 1.552 mg/L 3compartmentss NA 50% Human Human -DTXSID6048628 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID6048628 Css NA 1.078 mg/L PBTK NA 50% Human Human -DTXSID6048628 Css NA 6.553 mg/L PBTK NA 95% Human Human -DTXSID6048628 Clint NA 13.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048628 Fup NA 0.0807 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048628 Vd NA 2.15 L/kg 1compartment NA NA Rat Human -DTXSID6048628 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6048628 TK.Half.Life NA 6.762 hours 1compartment NA NA Rat Human -DTXSID6048628 Css NA 0.8639 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048628 Css NA 4.087 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048628 Css NA 0.5714 mg/L PBTK NA 50% Rat Human -DTXSID6048628 Css NA 2.635 mg/L PBTK NA 95% Rat Human -DTXSID6048670 Clint NA 2.504 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048670 Fup NA 0.0091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048670 Vd NA 0.2027 L/kg 1compartment NA NA Human Human -DTXSID6048670 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6048670 TK.Half.Life NA 27.78 hours 1compartment NA NA Human Human -DTXSID6048670 Css NA 24.87 mg/L 3compartmentss NA 50% Human Human -DTXSID6048670 Css NA 192.5 mg/L 3compartmentss NA 95% Human Human -DTXSID6048670 Css NA 14.6 mg/L PBTK NA 50% Human Human -DTXSID6048670 Css NA 112 mg/L PBTK NA 95% Human Human -DTXSID6048670 Clint NA 2.504 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048670 Fup NA 0.0091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048670 Vd NA 0.1944 L/kg 1compartment NA NA Rat Human -DTXSID6048670 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6048670 TK.Half.Life NA 15.5 hours 1compartment NA NA Rat Human -DTXSID6048670 Css NA 12.06 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048670 Css NA 76.59 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048670 Css NA 6.61 mg/L PBTK NA 50% Rat Human -DTXSID6048670 Css NA 41.45 mg/L PBTK NA 95% Rat Human -DTXSID6048672 Clint NA 4.415 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048672 Fup NA 0.465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048672 Vd NA 1.16 L/kg 1compartment NA NA Human Human +DTXSID6048626 TK.Half.Life NA 0.6843 hours 1compartment NA NA Rat Human +DTXSID6048626 Css NA 0.03909 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048626 Css NA 0.1715 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048626 Css NA 0.02554 mg/L PBTK NA 50% Rat Human +DTXSID6048626 Css NA 0.1046 mg/L PBTK NA 95% Rat Human +DTXSID6048628 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048628 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048628 Vd NA 3.107 L/kg 1compartment NA NA Human Human +DTXSID6048628 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID6048628 TK.Half.Life NA 49.83 hours 1compartment NA NA Human Human +DTXSID6048628 Css NA 1.852 mg/L 3compartmentss NA 50% Human Human +DTXSID6048628 Css NA 12.35 mg/L 3compartmentss NA 95% Human Human +DTXSID6048628 Css NA 1.287 mg/L PBTK NA 50% Human Human +DTXSID6048628 Css NA 8.434 mg/L PBTK NA 95% Human Human +DTXSID6048628 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048628 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048628 Vd NA 2.331 L/kg 1compartment NA NA Rat Human +DTXSID6048628 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6048628 TK.Half.Life NA 7.111 hours 1compartment NA NA Rat Human +DTXSID6048628 Css NA 0.2373 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048628 Css NA 1.313 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048628 Css NA 0.1643 mg/L PBTK NA 50% Rat Human +DTXSID6048628 Css NA 0.8846 mg/L PBTK NA 95% Rat Human +DTXSID6048670 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048670 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048670 Vd NA 0.2414 L/kg 1compartment NA NA Human Human +DTXSID6048670 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048670 TK.Half.Life NA 2.519 hours 1compartment NA NA Human Human +DTXSID6048670 Css NA 1.53 mg/L 3compartmentss NA 50% Human Human +DTXSID6048670 Css NA 15.43 mg/L 3compartmentss NA 95% Human Human +DTXSID6048670 Css NA 0.9124 mg/L PBTK NA 50% Human Human +DTXSID6048670 Css NA 8.93 mg/L PBTK NA 95% Human Human +DTXSID6048670 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048670 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048670 Vd NA 0.2289 L/kg 1compartment NA NA Rat Human +DTXSID6048670 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048670 TK.Half.Life NA 1.574 hours 1compartment NA NA Rat Human +DTXSID6048670 Css NA 0.07725 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048670 Css NA 0.8307 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048670 Css NA 0.04387 mg/L PBTK NA 50% Rat Human +DTXSID6048670 Css NA 0.4642 mg/L PBTK NA 95% Rat Human +DTXSID6048672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048672 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048672 Vd NA 0.9272 L/kg 1compartment NA NA Human Human DTXSID6048672 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048672 TK.Half.Life NA 2.669 hours 1compartment NA NA Human Human -DTXSID6048672 Css NA 0.1975 mg/L 3compartmentss NA 50% Human Human -DTXSID6048672 Css NA 1.284 mg/L 3compartmentss NA 95% Human Human -DTXSID6048672 Css NA 0.1606 mg/L PBTK NA 50% Human Human -DTXSID6048672 Css NA 0.8906 mg/L PBTK NA 95% Human Human -DTXSID6048672 Clint NA 4.415 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048672 Fup NA 0.465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048672 Vd NA 1.018 L/kg 1compartment NA NA Rat Human +DTXSID6048672 TK.Half.Life NA 1.304 hours 1compartment NA NA Human Human +DTXSID6048672 Css NA 0.07874 mg/L 3compartmentss NA 50% Human Human +DTXSID6048672 Css NA 0.584 mg/L 3compartmentss NA 95% Human Human +DTXSID6048672 Css NA 0.05671 mg/L PBTK NA 50% Human Human +DTXSID6048672 Css NA 0.3855 mg/L PBTK NA 95% Human Human +DTXSID6048672 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048672 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048672 Vd NA 0.7961 L/kg 1compartment NA NA Rat Human DTXSID6048672 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048672 TK.Half.Life NA 1.238 hours 1compartment NA NA Rat Human -DTXSID6048672 Css NA 0.09461 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048672 Css NA 0.5098 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048672 Css NA 0.07453 mg/L PBTK NA 50% Rat Human -DTXSID6048672 Css NA 0.3238 mg/L PBTK NA 95% Rat Human -DTXSID6048674 Clint NA 44.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048674 Fup NA 0.254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048674 Vd NA 2.467 L/kg 1compartment NA NA Human Human +DTXSID6048672 TK.Half.Life NA 0.5889 hours 1compartment NA NA Rat Human +DTXSID6048672 Css NA 0.009906 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048672 Css NA 0.0547 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048672 Css NA 0.007104 mg/L PBTK NA 50% Rat Human +DTXSID6048672 Css NA 0.03673 mg/L PBTK NA 95% Rat Human +DTXSID6048674 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048674 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048674 Vd NA 3.537 L/kg 1compartment NA NA Human Human DTXSID6048674 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048674 TK.Half.Life NA 2.205 hours 1compartment NA NA Human Human -DTXSID6048674 Css NA 0.03134 mg/L 3compartmentss NA 50% Human Human -DTXSID6048674 Css NA 0.2507 mg/L 3compartmentss NA 95% Human Human -DTXSID6048674 Css NA 0.02944 mg/L PBTK NA 50% Human Human -DTXSID6048674 Css NA 0.1999 mg/L PBTK NA 95% Human Human -DTXSID6048674 Clint NA 44.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048674 Fup NA 0.254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048674 Vd NA 2.422 L/kg 1compartment NA NA Rat Human +DTXSID6048674 TK.Half.Life NA 11.3 hours 1compartment NA NA Human Human +DTXSID6048674 Css NA 0.2342 mg/L 3compartmentss NA 50% Human Human +DTXSID6048674 Css NA 1.486 mg/L 3compartmentss NA 95% Human Human +DTXSID6048674 Css NA 0.235 mg/L PBTK NA 50% Human Human +DTXSID6048674 Css NA 1.268 mg/L PBTK NA 95% Human Human +DTXSID6048674 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048674 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048674 Vd NA 3.269 L/kg 1compartment NA NA Rat Human DTXSID6048674 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048674 TK.Half.Life NA 1.103 hours 1compartment NA NA Rat Human -DTXSID6048674 Css NA 0.01693 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048674 Css NA 0.1071 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048674 Css NA 0.01556 mg/L PBTK NA 50% Rat Human -DTXSID6048674 Css NA 0.08371 mg/L PBTK NA 95% Rat Human -DTXSID6048676 Clint NA 156.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048676 Fup NA 0.1423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048676 Vd NA 2.432 L/kg 1compartment NA NA Human Human +DTXSID6048674 TK.Half.Life NA 4.731 hours 1compartment NA NA Rat Human +DTXSID6048674 Css NA 0.02747 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048674 Css NA 0.1239 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048674 Css NA 0.02816 mg/L PBTK NA 50% Rat Human +DTXSID6048674 Css NA 0.1067 mg/L PBTK NA 95% Rat Human +DTXSID6048676 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048676 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048676 Vd NA 0.7877 L/kg 1compartment NA NA Human Human DTXSID6048676 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048676 TK.Half.Life NA 2.149 hours 1compartment NA NA Human Human -DTXSID6048676 Css NA 0.02509 mg/L 3compartmentss NA 50% Human Human -DTXSID6048676 Css NA 0.2087 mg/L 3compartmentss NA 95% Human Human -DTXSID6048676 Css NA 0.01978 mg/L PBTK NA 50% Human Human -DTXSID6048676 Css NA 0.1491 mg/L PBTK NA 95% Human Human -DTXSID6048676 Clint NA 156.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048676 Fup NA 0.1423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048676 Vd NA 2.125 L/kg 1compartment NA NA Rat Human +DTXSID6048676 TK.Half.Life NA 1.587 hours 1compartment NA NA Human Human +DTXSID6048676 Css NA 0.158 mg/L 3compartmentss NA 50% Human Human +DTXSID6048676 Css NA 1.108 mg/L 3compartmentss NA 95% Human Human +DTXSID6048676 Css NA 0.1198 mg/L PBTK NA 50% Human Human +DTXSID6048676 Css NA 0.7409 mg/L PBTK NA 95% Human Human +DTXSID6048676 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048676 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048676 Vd NA 0.8076 L/kg 1compartment NA NA Rat Human DTXSID6048676 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048676 TK.Half.Life NA 0.8553 hours 1compartment NA NA Rat Human -DTXSID6048676 Css NA 0.014 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048676 Css NA 0.09364 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048676 Css NA 0.0106 mg/L PBTK NA 50% Rat Human -DTXSID6048676 Css NA 0.06415 mg/L PBTK NA 95% Rat Human +DTXSID6048676 TK.Half.Life NA 0.913 hours 1compartment NA NA Rat Human +DTXSID6048676 Css NA 0.01815 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048676 Css NA 0.09538 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048676 Css NA 0.01378 mg/L PBTK NA 50% Rat Human +DTXSID6048676 Css NA 0.06228 mg/L PBTK NA 95% Rat Human DTXSID6048678 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6048678 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048678 Vd NA 0.6591 L/kg 1compartment NA NA Human Human +DTXSID6048678 Vd NA 0.645 L/kg 1compartment NA NA Human Human DTXSID6048678 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048678 TK.Half.Life NA 4.266 hours 1compartment NA NA Human Human -DTXSID6048678 Css NA 0.8575 mg/L 3compartmentss NA 50% Human Human -DTXSID6048678 Css NA 5.589 mg/L 3compartmentss NA 95% Human Human -DTXSID6048678 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID6048678 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID6048678 TK.Half.Life NA 4.176 hours 1compartment NA NA Human Human +DTXSID6048678 Css NA 0.7242 mg/L 3compartmentss NA 50% Human Human +DTXSID6048678 Css NA 5.098 mg/L 3compartmentss NA 95% Human Human +DTXSID6048678 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID6048678 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID6048678 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6048678 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048678 Vd NA 0.7153 L/kg 1compartment NA NA Rat Human +DTXSID6048678 Vd NA 0.7014 L/kg 1compartment NA NA Rat Human DTXSID6048678 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048678 TK.Half.Life NA 1.577 hours 1compartment NA NA Rat Human -DTXSID6048678 Css NA 0.2157 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048678 Css NA 1.344 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048678 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID6048678 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID6048705 Clint NA 8.488 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048705 Fup NA 0.0269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048705 Vd NA 1.668 L/kg 1compartment NA NA Human Human -DTXSID6048705 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6048705 TK.Half.Life NA 29.66 hours 1compartment NA NA Human Human -DTXSID6048705 Css NA 2.884 mg/L 3compartmentss NA 50% Human Human -DTXSID6048705 Css NA 23.03 mg/L 3compartmentss NA 95% Human Human -DTXSID6048705 Css NA 1.822 mg/L PBTK NA 50% Human Human -DTXSID6048705 Css NA 13.95 mg/L PBTK NA 95% Human Human -DTXSID6048705 Clint NA 8.488 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048705 Fup NA 0.0269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048705 Vd NA 1.239 L/kg 1compartment NA NA Rat Human -DTXSID6048705 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6048705 TK.Half.Life NA 10.59 hours 1compartment NA NA Rat Human -DTXSID6048705 Css NA 1.572 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048705 Css NA 9.248 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048705 Css NA 0.9366 mg/L PBTK NA 50% Rat Human -DTXSID6048705 Css NA 5.21 mg/L PBTK NA 95% Rat Human +DTXSID6048678 TK.Half.Life NA 1.547 hours 1compartment NA NA Rat Human +DTXSID6048678 Css NA 0.01331 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048678 Css NA 0.101 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048678 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID6048678 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID6048705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048705 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048705 Vd NA 1.77 L/kg 1compartment NA NA Human Human +DTXSID6048705 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048705 TK.Half.Life NA 12.5 hours 1compartment NA NA Human Human +DTXSID6048705 Css NA 0.894 mg/L 3compartmentss NA 50% Human Human +DTXSID6048705 Css NA 7.679 mg/L 3compartmentss NA 95% Human Human +DTXSID6048705 Css NA 0.5706 mg/L PBTK NA 50% Human Human +DTXSID6048705 Css NA 4.69 mg/L PBTK NA 95% Human Human +DTXSID6048705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048705 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048705 Vd NA 1.316 L/kg 1compartment NA NA Rat Human +DTXSID6048705 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048705 TK.Half.Life NA 4.39 hours 1compartment NA NA Rat Human +DTXSID6048705 Css NA 0.04488 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048705 Css NA 0.405 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048705 Css NA 0.02762 mg/L PBTK NA 50% Rat Human +DTXSID6048705 Css NA 0.2435 mg/L PBTK NA 95% Rat Human DTXSID6048707 Clint NA 9471 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6048707 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048707 Vd NA 13.94 L/kg 1compartment NA NA Human Human +DTXSID6048707 Vd NA 9.158 L/kg 1compartment NA NA Human Human DTXSID6048707 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048707 TK.Half.Life NA 5.904 hours 1compartment NA NA Human Human -DTXSID6048707 Css NA 0.003694 mg/L 3compartmentss NA 50% Human Human -DTXSID6048707 Css NA 0.0205 mg/L 3compartmentss NA 95% Human Human -DTXSID6048707 Css NA 0.005651 mg/L PBTK NA 50% Human Human -DTXSID6048707 Css NA 0.03074 mg/L PBTK NA 95% Human Human +DTXSID6048707 TK.Half.Life NA 5.15 hours 1compartment NA NA Human Human +DTXSID6048707 Css NA 0.00238 mg/L 3compartmentss NA 50% Human Human +DTXSID6048707 Css NA 0.02285 mg/L 3compartmentss NA 95% Human Human +DTXSID6048707 Css NA 0.00265 mg/L PBTK NA 50% Human Human +DTXSID6048707 Css NA 0.02464 mg/L PBTK NA 95% Human Human DTXSID6048707 Clint NA 9471 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6048707 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048707 Vd NA 11.14 L/kg 1compartment NA NA Rat Human +DTXSID6048707 Vd NA 7.182 L/kg 1compartment NA NA Rat Human DTXSID6048707 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048707 TK.Half.Life NA 1.871 hours 1compartment NA NA Rat Human -DTXSID6048707 Css NA 0.001976 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048707 Css NA 0.008536 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048707 Css NA 0.00307 mg/L PBTK NA 50% Rat Human -DTXSID6048707 Css NA 0.01337 mg/L PBTK NA 95% Rat Human -DTXSID6048709 Clint NA 0.01516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048709 Fup NA 0.422 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048709 Vd NA 0.4714 L/kg 1compartment NA NA Human Human +DTXSID6048707 TK.Half.Life NA 1.644 hours 1compartment NA NA Rat Human +DTXSID6048707 Css NA 7.392e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048707 Css NA 0.0009533 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048707 Css NA 8.47e-05 mg/L PBTK NA 50% Rat Human +DTXSID6048707 Css NA 0.001043 mg/L PBTK NA 95% Rat Human +DTXSID6048709 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048709 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048709 Vd NA 0.4849 L/kg 1compartment NA NA Human Human DTXSID6048709 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048709 TK.Half.Life NA 7.051 hours 1compartment NA NA Human Human -DTXSID6048709 Css NA 1.684 mg/L 3compartmentss NA 50% Human Human -DTXSID6048709 Css NA 7.662 mg/L 3compartmentss NA 95% Human Human -DTXSID6048709 Css NA 1.241 mg/L PBTK NA 50% Human Human -DTXSID6048709 Css NA 4.832 mg/L PBTK NA 95% Human Human -DTXSID6048709 Clint NA 0.01516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048709 Fup NA 0.422 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048709 Vd NA 0.4737 L/kg 1compartment NA NA Rat Human +DTXSID6048709 TK.Half.Life NA 4.346 hours 1compartment NA NA Human Human +DTXSID6048709 Css NA 0.9786 mg/L 3compartmentss NA 50% Human Human +DTXSID6048709 Css NA 6.003 mg/L 3compartmentss NA 95% Human Human +DTXSID6048709 Css NA 0.734 mg/L PBTK NA 50% Human Human +DTXSID6048709 Css NA 3.76 mg/L PBTK NA 95% Human Human +DTXSID6048709 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048709 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048709 Vd NA 0.5012 L/kg 1compartment NA NA Rat Human DTXSID6048709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048709 TK.Half.Life NA 2.445 hours 1compartment NA NA Rat Human -DTXSID6048709 Css NA 0.4686 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048709 Css NA 1.849 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048709 Css NA 0.3282 mg/L PBTK NA 50% Rat Human -DTXSID6048709 Css NA 1.088 mg/L PBTK NA 95% Rat Human -DTXSID6048751 Clint NA 33.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048751 Fup NA 0.0278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048751 Vd NA 2.072 L/kg 1compartment NA NA Human Human +DTXSID6048709 TK.Half.Life NA 1.53 hours 1compartment NA NA Rat Human +DTXSID6048709 Css NA 0.01897 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048709 Css NA 0.1449 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048709 Css NA 0.01354 mg/L PBTK NA 50% Rat Human +DTXSID6048709 Css NA 0.089 mg/L PBTK NA 95% Rat Human +DTXSID6048751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048751 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048751 Vd NA 1.798 L/kg 1compartment NA NA Human Human DTXSID6048751 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048751 TK.Half.Life NA 11.62 hours 1compartment NA NA Human Human -DTXSID6048751 Css NA 0.7702 mg/L 3compartmentss NA 50% Human Human -DTXSID6048751 Css NA 6.903 mg/L 3compartmentss NA 95% Human Human -DTXSID6048751 Css NA 0.507 mg/L PBTK NA 50% Human Human -DTXSID6048751 Css NA 4.253 mg/L PBTK NA 95% Human Human -DTXSID6048751 Clint NA 33.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048751 Fup NA 0.0278 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048751 Vd NA 1.584 L/kg 1compartment NA NA Rat Human +DTXSID6048751 TK.Half.Life NA 4.909 hours 1compartment NA NA Human Human +DTXSID6048751 Css NA 0.286 mg/L 3compartmentss NA 50% Human Human +DTXSID6048751 Css NA 2.161 mg/L 3compartmentss NA 95% Human Human +DTXSID6048751 Css NA 0.199 mg/L PBTK NA 50% Human Human +DTXSID6048751 Css NA 1.406 mg/L PBTK NA 95% Human Human +DTXSID6048751 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048751 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048751 Vd NA 1.478 L/kg 1compartment NA NA Rat Human DTXSID6048751 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048751 TK.Half.Life NA 3.941 hours 1compartment NA NA Rat Human -DTXSID6048751 Css NA 0.4324 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048751 Css NA 3.048 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048751 Css NA 0.268 mg/L PBTK NA 50% Rat Human -DTXSID6048751 Css NA 1.795 mg/L PBTK NA 95% Rat Human -DTXSID6048753 Clint NA 161.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048753 Fup NA 0.5859 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048753 Vd NA 3.217 L/kg 1compartment NA NA Human Human -DTXSID6048753 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048753 TK.Half.Life NA 4.844 hours 1compartment NA NA Human Human -DTXSID6048753 Css NA 0.08599 mg/L 3compartmentss NA 50% Human Human -DTXSID6048753 Css NA 0.533 mg/L 3compartmentss NA 95% Human Human -DTXSID6048753 Css NA 0.0611 mg/L PBTK NA 50% Human Human -DTXSID6048753 Css NA 0.3629 mg/L PBTK NA 95% Human Human -DTXSID6048753 Clint NA 161.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048753 Fup NA 0.5859 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048753 Vd NA 2.439 L/kg 1compartment NA NA Rat Human -DTXSID6048753 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048753 TK.Half.Life NA 1.146 hours 1compartment NA NA Rat Human -DTXSID6048753 Css NA 0.04775 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048753 Css NA 0.2566 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048753 Css NA 0.0326 mg/L PBTK NA 50% Rat Human -DTXSID6048753 Css NA 0.1704 mg/L PBTK NA 95% Rat Human -DTXSID6048755 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048755 Fup NA 0.218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048755 Vd NA 0.3874 L/kg 1compartment NA NA Human Human -DTXSID6048755 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6048755 TK.Half.Life NA 11.51 hours 1compartment NA NA Human Human -DTXSID6048755 Css NA 3.676 mg/L 3compartmentss NA 50% Human Human -DTXSID6048755 Css NA 13.37 mg/L 3compartmentss NA 95% Human Human -DTXSID6048755 Css NA 2.437 mg/L PBTK NA 50% Human Human -DTXSID6048755 Css NA 8.175 mg/L PBTK NA 95% Human Human -DTXSID6048755 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048755 Fup NA 0.218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048755 Vd NA 0.3884 L/kg 1compartment NA NA Rat Human -DTXSID6048755 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048755 TK.Half.Life NA 3.929 hours 1compartment NA NA Rat Human -DTXSID6048755 Css NA 1.023 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048755 Css NA 3.061 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048755 Css NA 0.6384 mg/L PBTK NA 50% Rat Human -DTXSID6048755 Css NA 1.747 mg/L PBTK NA 95% Rat Human -DTXSID6048757 Clint NA 12.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048757 Fup NA 0.2052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048757 Vd NA 0.5619 L/kg 1compartment NA NA Human Human +DTXSID6048751 TK.Half.Life NA 2.056 hours 1compartment NA NA Rat Human +DTXSID6048751 Css NA 0.03615 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048751 Css NA 0.2233 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048751 Css NA 0.0248 mg/L PBTK NA 50% Rat Human +DTXSID6048751 Css NA 0.1408 mg/L PBTK NA 95% Rat Human +DTXSID6048757 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048757 Fup 0.419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048757 Vd NA 0.6731 L/kg 1compartment NA NA Human Human DTXSID6048757 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048757 TK.Half.Life NA 1.212 hours 1compartment NA NA Human Human -DTXSID6048757 Css NA 0.1807 mg/L 3compartmentss NA 50% Human Human -DTXSID6048757 Css NA 1.194 mg/L 3compartmentss NA 95% Human Human -DTXSID6048757 Css NA 0.122 mg/L PBTK NA 50% Human Human -DTXSID6048757 Css NA 0.7535 mg/L PBTK NA 95% Human Human -DTXSID6048757 Clint NA 12.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048757 Fup NA 0.2052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048757 Vd NA 0.518 L/kg 1compartment NA NA Rat Human +DTXSID6048757 TK.Half.Life NA 1.32 hours 1compartment NA NA Human Human +DTXSID6048757 Css NA 0.155 mg/L 3compartmentss NA 50% Human Human +DTXSID6048757 Css NA 1.04 mg/L 3compartmentss NA 95% Human Human +DTXSID6048757 Css NA 0.1158 mg/L PBTK NA 50% Human Human +DTXSID6048757 Css NA 0.6966 mg/L PBTK NA 95% Human Human +DTXSID6048757 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048757 Fup 0.419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048757 Vd NA 0.6538 L/kg 1compartment NA NA Rat Human DTXSID6048757 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048757 TK.Half.Life NA 0.6377 hours 1compartment NA NA Rat Human -DTXSID6048757 Css NA 0.09822 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048757 Css NA 0.4657 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048757 Css NA 0.06312 mg/L PBTK NA 50% Rat Human -DTXSID6048757 Css NA 0.2831 mg/L PBTK NA 95% Rat Human -DTXSID6048759 Clint NA 35.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048759 Fup NA 0.0447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048759 Vd NA 0.774 L/kg 1compartment NA NA Human Human +DTXSID6048757 TK.Half.Life NA 0.711 hours 1compartment NA NA Rat Human +DTXSID6048757 Css NA 0.01784 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048757 Css NA 0.09524 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048757 Css NA 0.01343 mg/L PBTK NA 50% Rat Human +DTXSID6048757 Css NA 0.0604 mg/L PBTK NA 95% Rat Human +DTXSID6048759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048759 Fup 0.0833 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048759 Vd NA 1.332 L/kg 1compartment NA NA Human Human DTXSID6048759 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048759 TK.Half.Life NA 2.521 hours 1compartment NA NA Human Human -DTXSID6048759 Css NA 0.4306 mg/L 3compartmentss NA 50% Human Human -DTXSID6048759 Css NA 3.389 mg/L 3compartmentss NA 95% Human Human -DTXSID6048759 Css NA 0.2647 mg/L PBTK NA 50% Human Human -DTXSID6048759 Css NA 2.045 mg/L PBTK NA 95% Human Human -DTXSID6048759 Clint NA 35.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048759 Fup NA 0.0447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048759 Vd NA 0.5994 L/kg 1compartment NA NA Rat Human +DTXSID6048759 TK.Half.Life NA 4.171 hours 1compartment NA NA Human Human +DTXSID6048759 Css NA 0.3636 mg/L 3compartmentss NA 50% Human Human +DTXSID6048759 Css NA 2.803 mg/L 3compartmentss NA 95% Human Human +DTXSID6048759 Css NA 0.235 mg/L PBTK NA 50% Human Human +DTXSID6048759 Css NA 1.723 mg/L PBTK NA 95% Human Human +DTXSID6048759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048759 Fup 0.0833 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048759 Vd NA 1.02 L/kg 1compartment NA NA Rat Human DTXSID6048759 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048759 TK.Half.Life NA 1.145 hours 1compartment NA NA Rat Human -DTXSID6048759 Css NA 0.2428 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048759 Css NA 1.626 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048759 Css NA 0.1393 mg/L PBTK NA 50% Rat Human -DTXSID6048759 Css NA 0.9129 mg/L PBTK NA 95% Rat Human -DTXSID6048830 Clint NA 8.931 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048830 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048830 Vd NA 0.2425 L/kg 1compartment NA NA Human Human -DTXSID6048830 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6048830 TK.Half.Life NA 21.63 hours 1compartment NA NA Human Human -DTXSID6048830 Css NA 16.8 mg/L 3compartmentss NA 50% Human Human -DTXSID6048830 Css NA 146.4 mg/L 3compartmentss NA 95% Human Human -DTXSID6048830 Css NA 9.917 mg/L PBTK NA 50% Human Human -DTXSID6048830 Css NA 84.85 mg/L PBTK NA 95% Human Human -DTXSID6048830 Clint NA 8.931 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048830 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048830 Vd NA 0.2251 L/kg 1compartment NA NA Rat Human -DTXSID6048830 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6048830 TK.Half.Life NA 13.18 hours 1compartment NA NA Rat Human -DTXSID6048830 Css NA 9.07 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048830 Css NA 59.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048830 Css NA 4.996 mg/L PBTK NA 50% Rat Human -DTXSID6048830 Css NA 32.29 mg/L PBTK NA 95% Rat Human -DTXSID6048832 Clint NA 78.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048832 Fup NA 0.1786 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048832 Vd NA 1.914 L/kg 1compartment NA NA Human Human -DTXSID6048832 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048832 TK.Half.Life NA 1.914 hours 1compartment NA NA Human Human -DTXSID6048832 Css NA 0.03488 mg/L 3compartmentss NA 50% Human Human -DTXSID6048832 Css NA 0.251 mg/L 3compartmentss NA 95% Human Human -DTXSID6048832 Css NA 0.02749 mg/L PBTK NA 50% Human Human -DTXSID6048832 Css NA 0.1825 mg/L PBTK NA 95% Human Human -DTXSID6048832 Clint NA 78.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048832 Fup NA 0.1786 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048832 Vd NA 1.706 L/kg 1compartment NA NA Rat Human -DTXSID6048832 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048832 TK.Half.Life NA 0.8229 hours 1compartment NA NA Rat Human -DTXSID6048832 Css NA 0.01885 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048832 Css NA 0.1127 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048832 Css NA 0.01431 mg/L PBTK NA 50% Rat Human -DTXSID6048832 Css NA 0.07686 mg/L PBTK NA 95% Rat Human -DTXSID6048834 Clint NA 28.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048834 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048834 Vd NA 0.1956 L/kg 1compartment NA NA Human Human +DTXSID6048759 TK.Half.Life NA 1.687 hours 1compartment NA NA Rat Human +DTXSID6048759 Css NA 0.04713 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048759 Css NA 0.2654 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048759 Css NA 0.02996 mg/L PBTK NA 50% Rat Human +DTXSID6048759 Css NA 0.1593 mg/L PBTK NA 95% Rat Human +DTXSID6048830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048830 Fup 0.00936 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048830 Vd NA 0.3122 L/kg 1compartment NA NA Human Human +DTXSID6048830 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048830 TK.Half.Life NA 5.825 hours 1compartment NA NA Human Human +DTXSID6048830 Css NA 3.232 mg/L 3compartmentss NA 50% Human Human +DTXSID6048830 Css NA 32.88 mg/L 3compartmentss NA 95% Human Human +DTXSID6048830 Css NA 1.935 mg/L PBTK NA 50% Human Human +DTXSID6048830 Css NA 19.3 mg/L PBTK NA 95% Human Human +DTXSID6048830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048830 Fup 0.00936 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048830 Vd NA 0.2869 L/kg 1compartment NA NA Rat Human +DTXSID6048830 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048830 TK.Half.Life NA 3.578 hours 1compartment NA NA Rat Human +DTXSID6048830 Css NA 0.4306 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048830 Css NA 3.506 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048830 Css NA 0.2504 mg/L PBTK NA 50% Rat Human +DTXSID6048830 Css NA 1.993 mg/L PBTK NA 95% Rat Human +DTXSID6048832 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048832 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048832 Vd NA 2.234 L/kg 1compartment NA NA Human Human +DTXSID6048832 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID6048832 TK.Half.Life NA 35.99 hours 1compartment NA NA Human Human +DTXSID6048832 Css NA 1.362 mg/L 3compartmentss NA 50% Human Human +DTXSID6048832 Css NA 6.718 mg/L 3compartmentss NA 95% Human Human +DTXSID6048832 Css NA 1.306 mg/L PBTK NA 50% Human Human +DTXSID6048832 Css NA 4.813 mg/L PBTK NA 95% Human Human +DTXSID6048832 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048832 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048832 Vd NA 2.146 L/kg 1compartment NA NA Rat Human +DTXSID6048832 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6048832 TK.Half.Life NA 10.89 hours 1compartment NA NA Rat Human +DTXSID6048832 Css NA 0.08328 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048832 Css NA 0.3788 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048832 Css NA 0.08141 mg/L PBTK NA 50% Rat Human +DTXSID6048832 Css NA 0.2614 mg/L PBTK NA 95% Rat Human +DTXSID6048834 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048834 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048834 Vd NA 0.6134 L/kg 1compartment NA NA Human Human DTXSID6048834 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048834 TK.Half.Life NA 2.03 hours 1compartment NA NA Human Human -DTXSID6048834 Css NA 1.804 mg/L 3compartmentss NA 50% Human Human -DTXSID6048834 Css NA 19.46 mg/L 3compartmentss NA 95% Human Human -DTXSID6048834 Css NA 1.061 mg/L PBTK NA 50% Human Human -DTXSID6048834 Css NA 11.3 mg/L PBTK NA 95% Human Human -DTXSID6048834 Clint NA 28.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048834 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048834 Vd NA 0.1879 L/kg 1compartment NA NA Rat Human +DTXSID6048834 TK.Half.Life NA 2.087 hours 1compartment NA NA Human Human +DTXSID6048834 Css NA 0.3306 mg/L 3compartmentss NA 50% Human Human +DTXSID6048834 Css NA 2.054 mg/L 3compartmentss NA 95% Human Human +DTXSID6048834 Css NA 0.2256 mg/L PBTK NA 50% Human Human +DTXSID6048834 Css NA 1.309 mg/L PBTK NA 95% Human Human +DTXSID6048834 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048834 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048834 Vd NA 0.5509 L/kg 1compartment NA NA Rat Human DTXSID6048834 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048834 TK.Half.Life NA 1.292 hours 1compartment NA NA Rat Human -DTXSID6048834 Css NA 1.048 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048834 Css NA 8.135 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048834 Css NA 0.571 mg/L PBTK NA 50% Rat Human -DTXSID6048834 Css NA 4.428 mg/L PBTK NA 95% Rat Human -DTXSID6048836 Clint NA 51.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048836 Fup NA 0.2364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048836 Vd NA 1.28 L/kg 1compartment NA NA Human Human +DTXSID6048834 TK.Half.Life NA 1.084 hours 1compartment NA NA Rat Human +DTXSID6048834 Css NA 0.03983 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048834 Css NA 0.1732 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048834 Css NA 0.02674 mg/L PBTK NA 50% Rat Human +DTXSID6048834 Css NA 0.1065 mg/L PBTK NA 95% Rat Human +DTXSID6048836 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048836 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048836 Vd NA 1.73 L/kg 1compartment NA NA Human Human DTXSID6048836 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048836 TK.Half.Life NA 1.401 hours 1compartment NA NA Human Human -DTXSID6048836 Css NA 0.04236 mg/L 3compartmentss NA 50% Human Human -DTXSID6048836 Css NA 0.3046 mg/L 3compartmentss NA 95% Human Human -DTXSID6048836 Css NA 0.03104 mg/L PBTK NA 50% Human Human -DTXSID6048836 Css NA 0.209 mg/L PBTK NA 95% Human Human -DTXSID6048836 Clint NA 51.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048836 Fup NA 0.2364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048836 Vd NA 1.038 L/kg 1compartment NA NA Rat Human +DTXSID6048836 TK.Half.Life NA 4.255 hours 1compartment NA NA Human Human +DTXSID6048836 Css NA 0.2042 mg/L 3compartmentss NA 50% Human Human +DTXSID6048836 Css NA 1.224 mg/L 3compartmentss NA 95% Human Human +DTXSID6048836 Css NA 0.1627 mg/L PBTK NA 50% Human Human +DTXSID6048836 Css NA 0.8674 mg/L PBTK NA 95% Human Human +DTXSID6048836 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048836 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048836 Vd NA 1.401 L/kg 1compartment NA NA Rat Human DTXSID6048836 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048836 TK.Half.Life NA 0.5479 hours 1compartment NA NA Rat Human -DTXSID6048836 Css NA 0.02383 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048836 Css NA 0.1321 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048836 Css NA 0.01652 mg/L PBTK NA 50% Rat Human -DTXSID6048836 Css NA 0.08764 mg/L PBTK NA 95% Rat Human -DTXSID6048838 Clint NA 74.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048838 Fup NA 0.0434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048838 Vd NA 0.2672 L/kg 1compartment NA NA Human Human +DTXSID6048836 TK.Half.Life NA 1.635 hours 1compartment NA NA Rat Human +DTXSID6048836 Css NA 0.02348 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048836 Css NA 0.1073 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048836 Css NA 0.01883 mg/L PBTK NA 50% Rat Human +DTXSID6048836 Css NA 0.07432 mg/L PBTK NA 95% Rat Human +DTXSID6048838 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048838 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048838 Vd NA 1.075 L/kg 1compartment NA NA Human Human DTXSID6048838 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048838 TK.Half.Life NA 0.5677 hours 1compartment NA NA Human Human -DTXSID6048838 Css NA 0.2244 mg/L 3compartmentss NA 50% Human Human -DTXSID6048838 Css NA 1.963 mg/L 3compartmentss NA 95% Human Human -DTXSID6048838 Css NA 0.1342 mg/L PBTK NA 50% Human Human -DTXSID6048838 Css NA 1.162 mg/L PBTK NA 95% Human Human -DTXSID6048838 Clint NA 74.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048838 Fup NA 0.0434 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048838 Vd NA 0.2513 L/kg 1compartment NA NA Rat Human +DTXSID6048838 TK.Half.Life NA 2.461 hours 1compartment NA NA Human Human +DTXSID6048838 Css NA 0.1844 mg/L 3compartmentss NA 50% Human Human +DTXSID6048838 Css NA 1.196 mg/L 3compartmentss NA 95% Human Human +DTXSID6048838 Css NA 0.1412 mg/L PBTK NA 50% Human Human +DTXSID6048838 Css NA 0.8279 mg/L PBTK NA 95% Human Human +DTXSID6048838 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048838 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048838 Vd NA 0.9304 L/kg 1compartment NA NA Rat Human DTXSID6048838 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048838 TK.Half.Life NA 0.3089 hours 1compartment NA NA Rat Human -DTXSID6048838 Css NA 0.1284 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048838 Css NA 0.9602 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048838 Css NA 0.07149 mg/L PBTK NA 50% Rat Human -DTXSID6048838 Css NA 0.5241 mg/L PBTK NA 95% Rat Human -DTXSID6048880 Clint NA 1132 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048880 Fup NA 0.1002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048880 Vd NA 0.8535 L/kg 1compartment NA NA Human Human +DTXSID6048838 TK.Half.Life NA 1.151 hours 1compartment NA NA Rat Human +DTXSID6048838 Css NA 0.02176 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048838 Css NA 0.1011 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048838 Css NA 0.01679 mg/L PBTK NA 50% Rat Human +DTXSID6048838 Css NA 0.06786 mg/L PBTK NA 95% Rat Human +DTXSID6048880 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048880 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048880 Vd NA 2.992 L/kg 1compartment NA NA Human Human DTXSID6048880 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048880 TK.Half.Life NA 0.7314 hours 1compartment NA NA Human Human -DTXSID6048880 Css NA 0.005325 mg/L 3compartmentss NA 50% Human Human -DTXSID6048880 Css NA 0.04997 mg/L 3compartmentss NA 95% Human Human -DTXSID6048880 Css NA 0.003554 mg/L PBTK NA 50% Human Human -DTXSID6048880 Css NA 0.03117 mg/L PBTK NA 95% Human Human -DTXSID6048880 Clint NA 1132 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048880 Fup NA 0.1002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048880 Vd NA 0.84 L/kg 1compartment NA NA Rat Human +DTXSID6048880 TK.Half.Life NA 3.95 hours 1compartment NA NA Human Human +DTXSID6048880 Css NA 0.07567 mg/L 3compartmentss NA 50% Human Human +DTXSID6048880 Css NA 0.8721 mg/L 3compartmentss NA 95% Human Human +DTXSID6048880 Css NA 0.08842 mg/L PBTK NA 50% Human Human +DTXSID6048880 Css NA 0.6857 mg/L PBTK NA 95% Human Human +DTXSID6048880 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048880 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048880 Vd NA 3.028 L/kg 1compartment NA NA Rat Human DTXSID6048880 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048880 TK.Half.Life NA 0.3216 hours 1compartment NA NA Rat Human -DTXSID6048880 Css NA 0.003062 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048880 Css NA 0.02249 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048880 Css NA 0.001922 mg/L PBTK NA 50% Rat Human -DTXSID6048880 Css NA 0.01329 mg/L PBTK NA 95% Rat Human -DTXSID6048882 Clint NA 75.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048882 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048882 Vd NA 3.914 L/kg 1compartment NA NA Human Human +DTXSID6048880 TK.Half.Life NA 2.265 hours 1compartment NA NA Rat Human +DTXSID6048880 Css NA 0.008419 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048880 Css NA 0.08788 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048880 Css NA 0.01022 mg/L PBTK NA 50% Rat Human +DTXSID6048880 Css NA 0.06321 mg/L PBTK NA 95% Rat Human +DTXSID6048882 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048882 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048882 Vd NA 2.757 L/kg 1compartment NA NA Human Human DTXSID6048882 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048882 TK.Half.Life NA 2.068 hours 1compartment NA NA Human Human -DTXSID6048882 Css NA 0.008536 mg/L 3compartmentss NA 50% Human Human -DTXSID6048882 Css NA 0.08216 mg/L 3compartmentss NA 95% Human Human -DTXSID6048882 Css NA 0.01093 mg/L PBTK NA 50% Human Human -DTXSID6048882 Css NA 0.07928 mg/L PBTK NA 95% Human Human -DTXSID6048882 Clint NA 75.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048882 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048882 Vd NA 3.983 L/kg 1compartment NA NA Rat Human +DTXSID6048882 TK.Half.Life NA 2.912 hours 1compartment NA NA Human Human +DTXSID6048882 Css NA 0.04554 mg/L 3compartmentss NA 50% Human Human +DTXSID6048882 Css NA 0.4022 mg/L 3compartmentss NA 95% Human Human +DTXSID6048882 Css NA 0.04673 mg/L PBTK NA 50% Human Human +DTXSID6048882 Css NA 0.3387 mg/L PBTK NA 95% Human Human +DTXSID6048882 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048882 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048882 Vd NA 2.788 L/kg 1compartment NA NA Rat Human DTXSID6048882 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048882 TK.Half.Life NA 1.025 hours 1compartment NA NA Rat Human -DTXSID6048882 Css NA 0.004523 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048882 Css NA 0.03597 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048882 Css NA 0.00576 mg/L PBTK NA 50% Rat Human -DTXSID6048882 Css NA 0.03433 mg/L PBTK NA 95% Rat Human -DTXSID6048884 Clint NA 219.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048884 Fup NA 0.5175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048884 Vd NA 4.179 L/kg 1compartment NA NA Human Human +DTXSID6048882 TK.Half.Life NA 1.635 hours 1compartment NA NA Rat Human +DTXSID6048882 Css NA 0.00559 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048882 Css NA 0.0388 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048882 Css NA 0.005947 mg/L PBTK NA 50% Rat Human +DTXSID6048882 Css NA 0.03169 mg/L PBTK NA 95% Rat Human +DTXSID6048884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048884 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048884 Vd NA 3.446 L/kg 1compartment NA NA Human Human DTXSID6048884 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048884 TK.Half.Life NA 1.686 hours 1compartment NA NA Human Human -DTXSID6048884 Css NA 0.002276 mg/L 3compartmentss NA 50% Human Human -DTXSID6048884 Css NA 0.02434 mg/L 3compartmentss NA 95% Human Human -DTXSID6048884 Css NA 0.003074 mg/L PBTK NA 50% Human Human -DTXSID6048884 Css NA 0.02369 mg/L PBTK NA 95% Human Human -DTXSID6048884 Clint NA 219.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048884 Fup NA 0.5175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048884 Vd NA 4.266 L/kg 1compartment NA NA Rat Human +DTXSID6048884 TK.Half.Life NA 2.638 hours 1compartment NA NA Human Human +DTXSID6048884 Css NA 0.02478 mg/L 3compartmentss NA 50% Human Human +DTXSID6048884 Css NA 0.2612 mg/L 3compartmentss NA 95% Human Human +DTXSID6048884 Css NA 0.03008 mg/L PBTK NA 50% Human Human +DTXSID6048884 Css NA 0.2382 mg/L PBTK NA 95% Human Human +DTXSID6048884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048884 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048884 Vd NA 3.504 L/kg 1compartment NA NA Rat Human DTXSID6048884 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048884 TK.Half.Life NA 0.78 hours 1compartment NA NA Rat Human -DTXSID6048884 Css NA 0.001163 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048884 Css NA 0.01249 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048884 Css NA 0.001607 mg/L PBTK NA 50% Rat Human -DTXSID6048884 Css NA 0.01114 mg/L PBTK NA 95% Rat Human -DTXSID6048886 Clint NA 167.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048886 Fup NA 0.6285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048886 Vd NA 3.471 L/kg 1compartment NA NA Human Human -DTXSID6048886 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048886 TK.Half.Life NA 1.465 hours 1compartment NA NA Human Human -DTXSID6048886 Css NA 0.002909 mg/L 3compartmentss NA 50% Human Human -DTXSID6048886 Css NA 0.03987 mg/L 3compartmentss NA 95% Human Human -DTXSID6048886 Css NA 0.00364 mg/L PBTK NA 50% Human Human -DTXSID6048886 Css NA 0.03501 mg/L PBTK NA 95% Human Human -DTXSID6048886 Clint NA 167.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048886 Fup NA 0.6285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048886 Vd NA 3.511 L/kg 1compartment NA NA Rat Human -DTXSID6048886 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048886 TK.Half.Life NA 0.6723 hours 1compartment NA NA Rat Human -DTXSID6048886 Css NA 0.00146 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048886 Css NA 0.01952 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048886 Css NA 0.001872 mg/L PBTK NA 50% Rat Human -DTXSID6048886 Css NA 0.01581 mg/L PBTK NA 95% Rat Human -DTXSID6048888 Clint NA 196.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048888 Fup NA 0.4233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048888 Vd NA 4.713 L/kg 1compartment NA NA Human Human +DTXSID6048884 TK.Half.Life NA 1.443 hours 1compartment NA NA Rat Human +DTXSID6048884 Css NA 0.002986 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048884 Css NA 0.02529 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048884 Css NA 0.003802 mg/L PBTK NA 50% Rat Human +DTXSID6048884 Css NA 0.02285 mg/L PBTK NA 95% Rat Human +DTXSID6048886 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048886 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048886 Vd NA 3.118 L/kg 1compartment NA NA Human Human +DTXSID6048886 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID6048886 TK.Half.Life NA 42.29 hours 1compartment NA NA Human Human +DTXSID6048886 Css NA 0.9238 mg/L 3compartmentss NA 50% Human Human +DTXSID6048886 Css NA 5.721 mg/L 3compartmentss NA 95% Human Human +DTXSID6048886 Css NA 1.118 mg/L PBTK NA 50% Human Human +DTXSID6048886 Css NA 4.514 mg/L PBTK NA 95% Human Human +DTXSID6048886 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048886 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048886 Vd NA 3.146 L/kg 1compartment NA NA Rat Human +DTXSID6048886 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6048886 TK.Half.Life NA 14.52 hours 1compartment NA NA Rat Human +DTXSID6048886 Css NA 0.05615 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048886 Css NA 0.3196 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048886 Css NA 0.06978 mg/L PBTK NA 50% Rat Human +DTXSID6048886 Css NA 0.2423 mg/L PBTK NA 95% Rat Human +DTXSID6048888 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048888 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048888 Vd NA 3.838 L/kg 1compartment NA NA Human Human DTXSID6048888 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048888 TK.Half.Life NA 1.907 hours 1compartment NA NA Human Human -DTXSID6048888 Css NA 0.002682 mg/L 3compartmentss NA 50% Human Human -DTXSID6048888 Css NA 0.02779 mg/L 3compartmentss NA 95% Human Human -DTXSID6048888 Css NA 0.003798 mg/L PBTK NA 50% Human Human -DTXSID6048888 Css NA 0.02907 mg/L PBTK NA 95% Human Human -DTXSID6048888 Clint NA 196.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048888 Fup NA 0.4233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048888 Vd NA 4.795 L/kg 1compartment NA NA Rat Human +DTXSID6048888 TK.Half.Life NA 3.416 hours 1compartment NA NA Human Human +DTXSID6048888 Css NA 0.03294 mg/L 3compartmentss NA 50% Human Human +DTXSID6048888 Css NA 0.3096 mg/L 3compartmentss NA 95% Human Human +DTXSID6048888 Css NA 0.04041 mg/L PBTK NA 50% Human Human +DTXSID6048888 Css NA 0.2943 mg/L PBTK NA 95% Human Human +DTXSID6048888 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048888 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048888 Vd NA 3.887 L/kg 1compartment NA NA Rat Human DTXSID6048888 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048888 TK.Half.Life NA 0.8858 hours 1compartment NA NA Rat Human -DTXSID6048888 Css NA 0.001387 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048888 Css NA 0.01279 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048888 Css NA 0.002007 mg/L PBTK NA 50% Rat Human -DTXSID6048888 Css NA 0.01306 mg/L PBTK NA 95% Rat Human -DTXSID6048911 Clint NA 4.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048911 Fup NA 0.354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048911 Vd NA 5.166 L/kg 1compartment NA NA Human Human +DTXSID6048888 TK.Half.Life NA 1.892 hours 1compartment NA NA Rat Human +DTXSID6048888 Css NA 0.003949 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048888 Css NA 0.02794 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048888 Css NA 0.005018 mg/L PBTK NA 50% Rat Human +DTXSID6048888 Css NA 0.02682 mg/L PBTK NA 95% Rat Human +DTXSID6048911 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048911 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048911 Vd NA 2.354 L/kg 1compartment NA NA Human Human DTXSID6048911 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048911 TK.Half.Life NA 10.33 hours 1compartment NA NA Human Human -DTXSID6048911 Css NA 0.0979 mg/L 3compartmentss NA 50% Human Human -DTXSID6048911 Css NA 0.8046 mg/L 3compartmentss NA 95% Human Human -DTXSID6048911 Css NA 0.1546 mg/L PBTK NA 50% Human Human -DTXSID6048911 Css NA 0.8449 mg/L PBTK NA 95% Human Human -DTXSID6048911 Clint NA 4.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048911 Fup NA 0.354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048911 Vd NA 5.245 L/kg 1compartment NA NA Rat Human +DTXSID6048911 TK.Half.Life NA 2.046 hours 1compartment NA NA Human Human +DTXSID6048911 Css NA 0.03155 mg/L 3compartmentss NA 50% Human Human +DTXSID6048911 Css NA 0.297 mg/L 3compartmentss NA 95% Human Human +DTXSID6048911 Css NA 0.03258 mg/L PBTK NA 50% Human Human +DTXSID6048911 Css NA 0.2455 mg/L PBTK NA 95% Human Human +DTXSID6048911 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048911 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048911 Vd NA 2.366 L/kg 1compartment NA NA Rat Human DTXSID6048911 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048911 TK.Half.Life NA 6.075 hours 1compartment NA NA Rat Human -DTXSID6048911 Css NA 0.04646 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048911 Css NA 0.2994 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048911 Css NA 0.07476 mg/L PBTK NA 50% Rat Human -DTXSID6048911 Css NA 0.299 mg/L PBTK NA 95% Rat Human -DTXSID6048915 Clint NA 0.3523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048915 Fup NA 0.6886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048915 Vd NA 1.901 L/kg 1compartment NA NA Human Human -DTXSID6048915 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6048915 TK.Half.Life NA 11.42 hours 1compartment NA NA Human Human -DTXSID6048915 Css NA 0.555 mg/L 3compartmentss NA 50% Human Human -DTXSID6048915 Css NA 4.241 mg/L 3compartmentss NA 95% Human Human -DTXSID6048915 Css NA 0.5544 mg/L PBTK NA 50% Human Human -DTXSID6048915 Css NA 2.908 mg/L PBTK NA 95% Human Human -DTXSID6048915 Clint NA 0.3523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048915 Fup NA 0.6886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048915 Vd NA 1.923 L/kg 1compartment NA NA Rat Human +DTXSID6048911 TK.Half.Life NA 1.094 hours 1compartment NA NA Rat Human +DTXSID6048911 Css NA 0.003805 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048911 Css NA 0.02861 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048911 Css NA 0.00403 mg/L PBTK NA 50% Rat Human +DTXSID6048911 Css NA 0.02313 mg/L PBTK NA 95% Rat Human +DTXSID6048913 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048913 Fup 0.0886 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048913 Vd NA 2.57 L/kg 1compartment NA NA Human Human +DTXSID6048913 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048913 TK.Half.Life NA 4.409 hours 1compartment NA NA Human Human +DTXSID6048913 Css NA 0.1328 mg/L 3compartmentss NA 50% Human Human +DTXSID6048913 Css NA 1.264 mg/L 3compartmentss NA 95% Human Human +DTXSID6048913 Css NA 0.116 mg/L PBTK NA 50% Human Human +DTXSID6048913 Css NA 0.9191 mg/L PBTK NA 95% Human Human +DTXSID6048913 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048913 Fup 0.0886 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048913 Vd NA 2.532 L/kg 1compartment NA NA Rat Human +DTXSID6048913 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048913 TK.Half.Life NA 2.513 hours 1compartment NA NA Rat Human +DTXSID6048913 Css NA 0.0172 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048913 Css NA 0.1348 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048913 Css NA 0.01499 mg/L PBTK NA 50% Rat Human +DTXSID6048913 Css NA 0.09536 mg/L PBTK NA 95% Rat Human +DTXSID6048915 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048915 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048915 Vd NA 1.407 L/kg 1compartment NA NA Human Human +DTXSID6048915 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6048915 TK.Half.Life NA 20.5 hours 1compartment NA NA Human Human +DTXSID6048915 Css NA 1.358 mg/L 3compartmentss NA 50% Human Human +DTXSID6048915 Css NA 6.906 mg/L 3compartmentss NA 95% Human Human +DTXSID6048915 Css NA 1.177 mg/L PBTK NA 50% Human Human +DTXSID6048915 Css NA 4.631 mg/L PBTK NA 95% Human Human +DTXSID6048915 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048915 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048915 Vd NA 1.416 L/kg 1compartment NA NA Rat Human DTXSID6048915 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048915 TK.Half.Life NA 4.82 hours 1compartment NA NA Rat Human -DTXSID6048915 Css NA 0.177 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048915 Css NA 1.391 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048915 Css NA 0.1748 mg/L PBTK NA 50% Rat Human -DTXSID6048915 Css NA 0.8771 mg/L PBTK NA 95% Rat Human -DTXSID6048917 Clint NA 15.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048917 Fup NA 0.1028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048917 Vd NA 3.44 L/kg 1compartment NA NA Human Human +DTXSID6048915 TK.Half.Life NA 7.021 hours 1compartment NA NA Rat Human +DTXSID6048915 Css NA 0.0855 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048915 Css NA 0.3801 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048915 Css NA 0.07424 mg/L PBTK NA 50% Rat Human +DTXSID6048915 Css NA 0.247 mg/L PBTK NA 95% Rat Human +DTXSID6048917 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048917 Fup 0.0853 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048917 Vd NA 2.965 L/kg 1compartment NA NA Human Human DTXSID6048917 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048917 TK.Half.Life NA 8.425 hours 1compartment NA NA Human Human -DTXSID6048917 Css NA 0.2132 mg/L 3compartmentss NA 50% Human Human -DTXSID6048917 Css NA 1.583 mg/L 3compartmentss NA 95% Human Human -DTXSID6048917 Css NA 0.1852 mg/L PBTK NA 50% Human Human -DTXSID6048917 Css NA 1.258 mg/L PBTK NA 95% Human Human -DTXSID6048917 Clint NA 15.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048917 Fup NA 0.1028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048917 Vd NA 3.042 L/kg 1compartment NA NA Rat Human +DTXSID6048917 TK.Half.Life NA 6.139 hours 1compartment NA NA Human Human +DTXSID6048917 Css NA 0.1718 mg/L 3compartmentss NA 50% Human Human +DTXSID6048917 Css NA 1.477 mg/L 3compartmentss NA 95% Human Human +DTXSID6048917 Css NA 0.1434 mg/L PBTK NA 50% Human Human +DTXSID6048917 Css NA 1.067 mg/L PBTK NA 95% Human Human +DTXSID6048917 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048917 Fup 0.0853 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048917 Vd NA 2.69 L/kg 1compartment NA NA Rat Human DTXSID6048917 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048917 TK.Half.Life NA 3.122 hours 1compartment NA NA Rat Human -DTXSID6048917 Css NA 0.1151 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048917 Css NA 0.7036 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048917 Css NA 0.09714 mg/L PBTK NA 50% Rat Human -DTXSID6048917 Css NA 0.5219 mg/L PBTK NA 95% Rat Human -DTXSID6048919 Clint NA 25.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048919 Fup NA 0.0879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048919 Vd NA 3.085 L/kg 1compartment NA NA Human Human -DTXSID6048919 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6048919 TK.Half.Life NA 39.97 hours 1compartment NA NA Human Human -DTXSID6048919 Css NA 1.545 mg/L 3compartmentss NA 50% Human Human -DTXSID6048919 Css NA 9.751 mg/L 3compartmentss NA 95% Human Human -DTXSID6048919 Css NA 1.073 mg/L PBTK NA 50% Human Human -DTXSID6048919 Css NA 6.538 mg/L PBTK NA 95% Human Human -DTXSID6048919 Clint NA 25.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048919 Fup NA 0.0879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048919 Vd NA 2.316 L/kg 1compartment NA NA Rat Human -DTXSID6048919 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6048919 TK.Half.Life NA 5.97 hours 1compartment NA NA Rat Human -DTXSID6048919 Css NA 0.8494 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048919 Css NA 4.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048919 Css NA 0.5642 mg/L PBTK NA 50% Rat Human -DTXSID6048919 Css NA 2.908 mg/L PBTK NA 95% Rat Human -DTXSID6048961 Clint NA 2.431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048961 Fup NA 0.1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048961 Vd NA 2.714 L/kg 1compartment NA NA Human Human -DTXSID6048961 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6048961 TK.Half.Life NA 26.43 hours 1compartment NA NA Human Human -DTXSID6048961 Css NA 1.092 mg/L 3compartmentss NA 50% Human Human -DTXSID6048961 Css NA 7.684 mg/L 3compartmentss NA 95% Human Human -DTXSID6048961 Css NA 0.9623 mg/L PBTK NA 50% Human Human -DTXSID6048961 Css NA 5.407 mg/L PBTK NA 95% Human Human -DTXSID6048961 Clint NA 2.431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048961 Fup NA 0.1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048961 Vd NA 2.637 L/kg 1compartment NA NA Rat Human -DTXSID6048961 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6048961 TK.Half.Life NA 14.26 hours 1compartment NA NA Rat Human -DTXSID6048961 Css NA 0.5387 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048961 Css NA 2.964 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048961 Css NA 0.4576 mg/L PBTK NA 50% Rat Human -DTXSID6048961 Css NA 1.926 mg/L PBTK NA 95% Rat Human +DTXSID6048917 TK.Half.Life NA 2.731 hours 1compartment NA NA Rat Human +DTXSID6048917 Css NA 0.02221 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048917 Css NA 0.1508 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048917 Css NA 0.01859 mg/L PBTK NA 50% Rat Human +DTXSID6048917 Css NA 0.1106 mg/L PBTK NA 95% Rat Human +DTXSID6048919 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048919 Fup 0.0854 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048919 Vd NA 2.092 L/kg 1compartment NA NA Human Human +DTXSID6048919 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6048919 TK.Half.Life NA 22.33 hours 1compartment NA NA Human Human +DTXSID6048919 Css NA 1.42 mg/L 3compartmentss NA 50% Human Human +DTXSID6048919 Css NA 8.715 mg/L 3compartmentss NA 95% Human Human +DTXSID6048919 Css NA 0.9636 mg/L PBTK NA 50% Human Human +DTXSID6048919 Css NA 5.528 mg/L PBTK NA 95% Human Human +DTXSID6048919 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048919 Fup 0.0854 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048919 Vd NA 1.588 L/kg 1compartment NA NA Rat Human +DTXSID6048919 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6048919 TK.Half.Life NA 6.911 hours 1compartment NA NA Rat Human +DTXSID6048919 Css NA 0.1753 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048919 Css NA 0.7773 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048919 Css NA 0.1164 mg/L PBTK NA 50% Rat Human +DTXSID6048919 Css NA 0.4898 mg/L PBTK NA 95% Rat Human +DTXSID6048961 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048961 Fup 0.0776 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048961 Vd NA 2.445 L/kg 1compartment NA NA Human Human +DTXSID6048961 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6048961 TK.Half.Life NA 12.38 hours 1compartment NA NA Human Human +DTXSID6048961 Css NA 0.5952 mg/L 3compartmentss NA 50% Human Human +DTXSID6048961 Css NA 3.848 mg/L 3compartmentss NA 95% Human Human +DTXSID6048961 Css NA 0.404 mg/L PBTK NA 50% Human Human +DTXSID6048961 Css NA 2.538 mg/L PBTK NA 95% Human Human +DTXSID6048961 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048961 Fup 0.0776 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048961 Vd NA 1.837 L/kg 1compartment NA NA Rat Human +DTXSID6048961 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6048961 TK.Half.Life NA 3.305 hours 1compartment NA NA Rat Human +DTXSID6048961 Css NA 0.0765 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048961 Css NA 0.3981 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048961 Css NA 0.05132 mg/L PBTK NA 50% Rat Human +DTXSID6048961 Css NA 0.2563 mg/L PBTK NA 95% Rat Human DTXSID6048963 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6048963 Fup NA 0.81 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048963 Vd NA 0.6558 L/kg 1compartment NA NA Human Human +DTXSID6048963 Vd NA 0.6103 L/kg 1compartment NA NA Human Human DTXSID6048963 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048963 TK.Half.Life NA 5.239 hours 1compartment NA NA Human Human -DTXSID6048963 Css NA 1.007 mg/L 3compartmentss NA 50% Human Human -DTXSID6048963 Css NA 5.838 mg/L 3compartmentss NA 95% Human Human -DTXSID6048963 Css NA 0.8113 mg/L PBTK NA 50% Human Human -DTXSID6048963 Css NA 3.758 mg/L PBTK NA 95% Human Human +DTXSID6048963 TK.Half.Life NA 4.874 hours 1compartment NA NA Human Human +DTXSID6048963 Css NA 0.8694 mg/L 3compartmentss NA 50% Human Human +DTXSID6048963 Css NA 5.24 mg/L 3compartmentss NA 95% Human Human +DTXSID6048963 Css NA 0.6894 mg/L PBTK NA 50% Human Human +DTXSID6048963 Css NA 3.286 mg/L PBTK NA 95% Human Human DTXSID6048963 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6048963 Fup NA 0.81 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048963 Vd NA 0.6935 L/kg 1compartment NA NA Rat Human +DTXSID6048963 Vd NA 0.6559 L/kg 1compartment NA NA Rat Human DTXSID6048963 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048963 TK.Half.Life NA 1.888 hours 1compartment NA NA Rat Human -DTXSID6048963 Css NA 0.258 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048963 Css NA 1.492 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048963 Css NA 0.2008 mg/L PBTK NA 50% Rat Human -DTXSID6048963 Css NA 0.8865 mg/L PBTK NA 95% Rat Human -DTXSID6048965 Clint NA 2.644 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048965 Fup NA 0.2386 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048965 Vd NA 0.4073 L/kg 1compartment NA NA Human Human +DTXSID6048963 TK.Half.Life NA 1.786 hours 1compartment NA NA Rat Human +DTXSID6048963 Css NA 0.01634 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048963 Css NA 0.1198 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048963 Css NA 0.0125 mg/L PBTK NA 50% Rat Human +DTXSID6048963 Css NA 0.07507 mg/L PBTK NA 95% Rat Human +DTXSID6048965 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048965 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048965 Vd NA 0.4143 L/kg 1compartment NA NA Human Human DTXSID6048965 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6048965 TK.Half.Life NA 2.227 hours 1compartment NA NA Human Human -DTXSID6048965 Css NA 0.6118 mg/L 3compartmentss NA 50% Human Human -DTXSID6048965 Css NA 3.235 mg/L 3compartmentss NA 95% Human Human -DTXSID6048965 Css NA 0.414 mg/L PBTK NA 50% Human Human -DTXSID6048965 Css NA 2.027 mg/L PBTK NA 95% Human Human -DTXSID6048965 Clint NA 2.644 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048965 Fup NA 0.2386 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048965 Vd NA 0.4129 L/kg 1compartment NA NA Rat Human +DTXSID6048965 TK.Half.Life NA 0.9062 hours 1compartment NA NA Human Human +DTXSID6048965 Css NA 0.09304 mg/L 3compartmentss NA 50% Human Human +DTXSID6048965 Css NA 0.6889 mg/L 3compartmentss NA 95% Human Human +DTXSID6048965 Css NA 0.06508 mg/L PBTK NA 50% Human Human +DTXSID6048965 Css NA 0.4498 mg/L PBTK NA 95% Human Human +DTXSID6048965 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048965 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048965 Vd NA 0.421 L/kg 1compartment NA NA Rat Human DTXSID6048965 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6048965 TK.Half.Life NA 1.266 hours 1compartment NA NA Rat Human -DTXSID6048965 Css NA 0.2934 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048965 Css NA 1.111 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048965 Css NA 0.1889 mg/L PBTK NA 50% Rat Human -DTXSID6048965 Css NA 0.6544 mg/L PBTK NA 95% Rat Human -DTXSID6048967 Clint NA 13.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048967 Fup NA 0.0419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048967 Vd NA 2.963 L/kg 1compartment NA NA Human Human -DTXSID6048967 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID6048967 TK.Half.Life NA 66.84 hours 1compartment NA NA Human Human -DTXSID6048967 Css NA 2.859 mg/L 3compartmentss NA 50% Human Human -DTXSID6048967 Css NA 17.41 mg/L 3compartmentss NA 95% Human Human -DTXSID6048967 Css NA 1.976 mg/L PBTK NA 50% Human Human -DTXSID6048967 Css NA 11.78 mg/L PBTK NA 95% Human Human -DTXSID6048967 Clint NA 13.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048967 Fup NA 0.0419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048967 Vd NA 2.221 L/kg 1compartment NA NA Rat Human -DTXSID6048967 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID6048967 TK.Half.Life NA 11.01 hours 1compartment NA NA Rat Human -DTXSID6048967 Css NA 1.578 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048967 Css NA 8.115 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048967 Css NA 1.038 mg/L PBTK NA 50% Rat Human -DTXSID6048967 Css NA 5.265 mg/L PBTK NA 95% Rat Human -DTXSID6048969 Clint NA 61.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048969 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6048969 Vd NA 26.13 L/kg 1compartment NA NA Human Human -DTXSID6048969 Days.Css NA 56 Days PBTK NA NA Human Human -DTXSID6048969 TK.Half.Life NA 280.5 hours 1compartment NA NA Human Human -DTXSID6048969 Css NA 0.3184 mg/L 3compartmentss NA 50% Human Human -DTXSID6048969 Css NA 1.946 mg/L 3compartmentss NA 95% Human Human -DTXSID6048969 Css NA 0.878 mg/L PBTK NA 50% Human Human -DTXSID6048969 Css NA 4.991 mg/L PBTK NA 95% Human Human -DTXSID6048969 Clint NA 61.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048969 Fup NA 0.0078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6048969 Vd NA 21.45 L/kg 1compartment NA NA Rat Human -DTXSID6048969 Days.Css NA 36 Days PBTK NA NA Rat Human -DTXSID6048969 TK.Half.Life NA 41.73 hours 1compartment NA NA Rat Human -DTXSID6048969 Css NA 0.166 mg/L 3compartmentss NA 50% Rat Human -DTXSID6048969 Css NA 0.7129 mg/L 3compartmentss NA 95% Rat Human -DTXSID6048969 Css NA 0.4744 mg/L PBTK NA 50% Rat Human -DTXSID6048969 Css NA 2.044 mg/L PBTK NA 95% Rat Human -DTXSID6049010 Clint NA 29.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049010 Fup NA 0.1253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049010 Vd NA 2.027 L/kg 1compartment NA NA Human Human +DTXSID6048965 TK.Half.Life NA 0.5169 hours 1compartment NA NA Rat Human +DTXSID6048965 Css NA 0.000884 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048965 Css NA 0.005597 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048965 Css NA 0.0005915 mg/L PBTK NA 50% Rat Human +DTXSID6048965 Css NA 0.003391 mg/L PBTK NA 95% Rat Human +DTXSID6048967 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048967 Fup 0.0212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048967 Vd NA 2.997 L/kg 1compartment NA NA Human Human +DTXSID6048967 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID6048967 TK.Half.Life NA 59.29 hours 1compartment NA NA Human Human +DTXSID6048967 Css NA 2.183 mg/L 3compartmentss NA 50% Human Human +DTXSID6048967 Css NA 14.17 mg/L 3compartmentss NA 95% Human Human +DTXSID6048967 Css NA 1.494 mg/L PBTK NA 50% Human Human +DTXSID6048967 Css NA 9.376 mg/L PBTK NA 95% Human Human +DTXSID6048967 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048967 Fup 0.0212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048967 Vd NA 2.243 L/kg 1compartment NA NA Rat Human +DTXSID6048967 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID6048967 TK.Half.Life NA 9.463 hours 1compartment NA NA Rat Human +DTXSID6048967 Css NA 0.1106 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048967 Css NA 0.7417 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048967 Css NA 0.0732 mg/L PBTK NA 50% Rat Human +DTXSID6048967 Css NA 0.4703 mg/L PBTK NA 95% Rat Human +DTXSID6048969 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048969 Fup 0.00752 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6048969 Vd NA 25.65 L/kg 1compartment NA NA Human Human +DTXSID6048969 Days.Css NA 182 Days PBTK NA NA Human Human +DTXSID6048969 TK.Half.Life NA 766.3 hours 1compartment NA NA Human Human +DTXSID6048969 Css NA 0.8902 mg/L 3compartmentss NA 50% Human Human +DTXSID6048969 Css NA 5.75 mg/L 3compartmentss NA 95% Human Human +DTXSID6048969 Css NA 2.388 mg/L PBTK NA 50% Human Human +DTXSID6048969 Css NA 14.56 mg/L PBTK NA 95% Human Human +DTXSID6048969 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048969 Fup 0.00752 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6048969 Vd NA 21.04 L/kg 1compartment NA NA Rat Human +DTXSID6048969 Days.Css NA 111 Days PBTK NA NA Rat Human +DTXSID6048969 TK.Half.Life NA 112.2 hours 1compartment NA NA Rat Human +DTXSID6048969 Css NA 0.1074 mg/L 3compartmentss NA 50% Rat Human +DTXSID6048969 Css NA 0.5213 mg/L 3compartmentss NA 95% Rat Human +DTXSID6048969 Css NA 0.3132 mg/L PBTK NA 50% Rat Human +DTXSID6048969 Css NA 1.633 mg/L PBTK NA 95% Rat Human +DTXSID6049010 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049010 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049010 Vd NA 2.196 L/kg 1compartment NA NA Human Human DTXSID6049010 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049010 TK.Half.Life NA 4.702 hours 1compartment NA NA Human Human -DTXSID6049010 Css NA 0.2228 mg/L 3compartmentss NA 50% Human Human -DTXSID6049010 Css NA 1.636 mg/L 3compartmentss NA 95% Human Human -DTXSID6049010 Css NA 0.1527 mg/L PBTK NA 50% Human Human -DTXSID6049010 Css NA 1.06 mg/L PBTK NA 95% Human Human -DTXSID6049010 Clint NA 29.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049010 Fup NA 0.1253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049010 Vd NA 1.543 L/kg 1compartment NA NA Rat Human +DTXSID6049010 TK.Half.Life NA 7.577 hours 1compartment NA NA Human Human +DTXSID6049010 Css NA 0.3696 mg/L 3compartmentss NA 50% Human Human +DTXSID6049010 Css NA 2.558 mg/L 3compartmentss NA 95% Human Human +DTXSID6049010 Css NA 0.2539 mg/L PBTK NA 50% Human Human +DTXSID6049010 Css NA 1.691 mg/L PBTK NA 95% Human Human +DTXSID6049010 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049010 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049010 Vd NA 1.662 L/kg 1compartment NA NA Rat Human DTXSID6049010 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049010 TK.Half.Life NA 1.566 hours 1compartment NA NA Rat Human -DTXSID6049010 Css NA 0.1233 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049010 Css NA 0.6805 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049010 Css NA 0.0803 mg/L PBTK NA 50% Rat Human -DTXSID6049010 Css NA 0.4255 mg/L PBTK NA 95% Rat Human -DTXSID6049012 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049012 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049012 Vd NA 0.7342 L/kg 1compartment NA NA Human Human -DTXSID6049012 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049012 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human -DTXSID6049012 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human -DTXSID6049012 Css NA 6.515 mg/L 3compartmentss NA 95% Human Human -DTXSID6049012 Css NA 0.8344 mg/L PBTK NA 50% Human Human -DTXSID6049012 Css NA 4.14 mg/L PBTK NA 95% Human Human -DTXSID6049012 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049012 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049012 Vd NA 0.7548 L/kg 1compartment NA NA Rat Human -DTXSID6049012 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049012 TK.Half.Life NA 2.172 hours 1compartment NA NA Rat Human -DTXSID6049012 Css NA 0.2618 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049012 Css NA 1.629 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049012 Css NA 0.208 mg/L PBTK NA 50% Rat Human -DTXSID6049012 Css NA 0.9689 mg/L PBTK NA 95% Rat Human -DTXSID6049016 Clint NA 6.271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049016 Fup NA 0.634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049016 Vd NA 2.193 L/kg 1compartment NA NA Human Human +DTXSID6049010 TK.Half.Life NA 2.335 hours 1compartment NA NA Rat Human +DTXSID6049010 Css NA 0.0482 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049010 Css NA 0.2592 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049010 Css NA 0.03254 mg/L PBTK NA 50% Rat Human +DTXSID6049010 Css NA 0.1679 mg/L PBTK NA 95% Rat Human +DTXSID6049016 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049016 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049016 Vd NA 2.363 L/kg 1compartment NA NA Human Human DTXSID6049016 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049016 TK.Half.Life NA 3.018 hours 1compartment NA NA Human Human -DTXSID6049016 Css NA 0.09308 mg/L 3compartmentss NA 50% Human Human -DTXSID6049016 Css NA 0.9302 mg/L 3compartmentss NA 95% Human Human -DTXSID6049016 Css NA 0.09154 mg/L PBTK NA 50% Human Human -DTXSID6049016 Css NA 0.6958 mg/L PBTK NA 95% Human Human -DTXSID6049016 Clint NA 6.271 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049016 Fup NA 0.634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049016 Vd NA 2.136 L/kg 1compartment NA NA Rat Human +DTXSID6049016 TK.Half.Life NA 3.168 hours 1compartment NA NA Human Human +DTXSID6049016 Css NA 0.08404 mg/L 3compartmentss NA 50% Human Human +DTXSID6049016 Css NA 0.902 mg/L 3compartmentss NA 95% Human Human +DTXSID6049016 Css NA 0.086 mg/L PBTK NA 50% Human Human +DTXSID6049016 Css NA 0.6567 mg/L PBTK NA 95% Human Human +DTXSID6049016 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049016 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049016 Vd NA 2.316 L/kg 1compartment NA NA Rat Human DTXSID6049016 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049016 TK.Half.Life NA 1.563 hours 1compartment NA NA Rat Human -DTXSID6049016 Css NA 0.04408 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049016 Css NA 0.3891 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049016 Css NA 0.04354 mg/L PBTK NA 50% Rat Human -DTXSID6049016 Css NA 0.2616 mg/L PBTK NA 95% Rat Human -DTXSID6049018 Clint NA 0.1882 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049018 Fup NA 0.4854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049018 Vd NA 0.3841 L/kg 1compartment NA NA Human Human +DTXSID6049016 TK.Half.Life NA 1.653 hours 1compartment NA NA Rat Human +DTXSID6049016 Css NA 0.009316 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049016 Css NA 0.0824 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049016 Css NA 0.009833 mg/L PBTK NA 50% Rat Human +DTXSID6049016 Css NA 0.05901 mg/L PBTK NA 95% Rat Human +DTXSID6049018 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049018 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049018 Vd NA 0.7916 L/kg 1compartment NA NA Human Human DTXSID6049018 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049018 TK.Half.Life NA 3.909 hours 1compartment NA NA Human Human -DTXSID6049018 Css NA 1.192 mg/L 3compartmentss NA 50% Human Human -DTXSID6049018 Css NA 5.779 mg/L 3compartmentss NA 95% Human Human -DTXSID6049018 Css NA 0.8394 mg/L PBTK NA 50% Human Human -DTXSID6049018 Css NA 3.56 mg/L PBTK NA 95% Human Human -DTXSID6049018 Clint NA 0.1882 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049018 Fup NA 0.4854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049018 Vd NA 0.3943 L/kg 1compartment NA NA Rat Human +DTXSID6049018 TK.Half.Life NA 0.7258 hours 1compartment NA NA Human Human +DTXSID6049018 Css NA 0.03366 mg/L 3compartmentss NA 50% Human Human +DTXSID6049018 Css NA 0.3836 mg/L 3compartmentss NA 95% Human Human +DTXSID6049018 Css NA 0.02705 mg/L PBTK NA 50% Human Human +DTXSID6049018 Css NA 0.261 mg/L PBTK NA 95% Human Human +DTXSID6049018 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049018 Fup 0.579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049018 Vd NA 0.7752 L/kg 1compartment NA NA Rat Human DTXSID6049018 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049018 TK.Half.Life NA 1.556 hours 1compartment NA NA Rat Human -DTXSID6049018 Css NA 0.38 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049018 Css NA 1.671 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049018 Css NA 0.253 mg/L PBTK NA 50% Rat Human -DTXSID6049018 Css NA 0.9569 mg/L PBTK NA 95% Rat Human -DTXSID6049060 Clint NA 53.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049060 Fup NA 0.0423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049060 Vd NA 2.488 L/kg 1compartment NA NA Human Human +DTXSID6049018 TK.Half.Life NA 0.3538 hours 1compartment NA NA Rat Human +DTXSID6049018 Css NA 0.004174 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049018 Css NA 0.03808 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049018 Css NA 0.00335 mg/L PBTK NA 50% Rat Human +DTXSID6049018 Css NA 0.02502 mg/L PBTK NA 95% Rat Human +DTXSID6049060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049060 Fup 0.0724 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049060 Vd NA 3.117 L/kg 1compartment NA NA Human Human DTXSID6049060 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049060 TK.Half.Life NA 3.802 hours 1compartment NA NA Human Human -DTXSID6049060 Css NA 0.122 mg/L 3compartmentss NA 50% Human Human -DTXSID6049060 Css NA 1.176 mg/L 3compartmentss NA 95% Human Human -DTXSID6049060 Css NA 0.09156 mg/L PBTK NA 50% Human Human -DTXSID6049060 Css NA 0.7691 mg/L PBTK NA 95% Human Human -DTXSID6049060 Clint NA 53.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049060 Fup NA 0.0423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049060 Vd NA 2.186 L/kg 1compartment NA NA Rat Human +DTXSID6049060 TK.Half.Life NA 6.442 hours 1compartment NA NA Human Human +DTXSID6049060 Css NA 0.1688 mg/L 3compartmentss NA 50% Human Human +DTXSID6049060 Css NA 1.35 mg/L 3compartmentss NA 95% Human Human +DTXSID6049060 Css NA 0.1403 mg/L PBTK NA 50% Human Human +DTXSID6049060 Css NA 1.002 mg/L PBTK NA 95% Human Human +DTXSID6049060 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049060 Fup 0.0724 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049060 Vd NA 2.764 L/kg 1compartment NA NA Rat Human DTXSID6049060 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049060 TK.Half.Life NA 1.627 hours 1compartment NA NA Rat Human -DTXSID6049060 Css NA 0.06904 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049060 Css NA 0.5033 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049060 Css NA 0.04918 mg/L PBTK NA 50% Rat Human -DTXSID6049060 Css NA 0.3099 mg/L PBTK NA 95% Rat Human -DTXSID6049062 Clint NA 11.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049062 Fup NA 0.1079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049062 Vd NA 3.146 L/kg 1compartment NA NA Human Human +DTXSID6049060 TK.Half.Life NA 2.596 hours 1compartment NA NA Rat Human +DTXSID6049060 Css NA 0.02197 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049060 Css NA 0.1431 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049060 Css NA 0.01825 mg/L PBTK NA 50% Rat Human +DTXSID6049060 Css NA 0.1084 mg/L PBTK NA 95% Rat Human +DTXSID6049062 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049062 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049062 Vd NA 0.359 L/kg 1compartment NA NA Human Human DTXSID6049062 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049062 TK.Half.Life NA 10.33 hours 1compartment NA NA Human Human -DTXSID6049062 Css NA 0.3196 mg/L 3compartmentss NA 50% Human Human -DTXSID6049062 Css NA 2.455 mg/L 3compartmentss NA 95% Human Human -DTXSID6049062 Css NA 0.2719 mg/L PBTK NA 50% Human Human -DTXSID6049062 Css NA 1.865 mg/L PBTK NA 95% Human Human -DTXSID6049062 Clint NA 11.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049062 Fup NA 0.1079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049062 Vd NA 2.831 L/kg 1compartment NA NA Rat Human +DTXSID6049062 TK.Half.Life NA 1.137 hours 1compartment NA NA Human Human +DTXSID6049062 Css NA 0.3144 mg/L 3compartmentss NA 50% Human Human +DTXSID6049062 Css NA 1.841 mg/L 3compartmentss NA 95% Human Human +DTXSID6049062 Css NA 0.208 mg/L PBTK NA 50% Human Human +DTXSID6049062 Css NA 1.162 mg/L PBTK NA 95% Human Human +DTXSID6049062 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049062 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049062 Vd NA 0.3705 L/kg 1compartment NA NA Rat Human DTXSID6049062 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049062 TK.Half.Life NA 4.338 hours 1compartment NA NA Rat Human -DTXSID6049062 Css NA 0.1733 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049062 Css NA 0.9897 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049062 Css NA 0.1435 mg/L PBTK NA 50% Rat Human -DTXSID6049062 Css NA 0.7107 mg/L PBTK NA 95% Rat Human -DTXSID6049064 Clint NA 6.809 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049064 Fup NA 0.3175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049064 Vd NA 0.8441 L/kg 1compartment NA NA Human Human +DTXSID6049062 TK.Half.Life NA 0.6816 hours 1compartment NA NA Rat Human +DTXSID6049062 Css NA 0.03722 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049062 Css NA 0.1645 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049062 Css NA 0.02416 mg/L PBTK NA 50% Rat Human +DTXSID6049062 Css NA 0.09846 mg/L PBTK NA 95% Rat Human +DTXSID6049064 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049064 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049064 Vd NA 1.673 L/kg 1compartment NA NA Human Human DTXSID6049064 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049064 TK.Half.Life NA 1.957 hours 1compartment NA NA Human Human -DTXSID6049064 Css NA 0.2011 mg/L 3compartmentss NA 50% Human Human -DTXSID6049064 Css NA 1.273 mg/L 3compartmentss NA 95% Human Human -DTXSID6049064 Css NA 0.1485 mg/L PBTK NA 50% Human Human -DTXSID6049064 Css NA 0.8387 mg/L PBTK NA 95% Human Human -DTXSID6049064 Clint NA 6.809 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049064 Fup NA 0.3175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049064 Vd NA 0.7571 L/kg 1compartment NA NA Rat Human +DTXSID6049064 TK.Half.Life NA 3.499 hours 1compartment NA NA Human Human +DTXSID6049064 Css NA 0.1604 mg/L 3compartmentss NA 50% Human Human +DTXSID6049064 Css NA 1.081 mg/L 3compartmentss NA 95% Human Human +DTXSID6049064 Css NA 0.1317 mg/L PBTK NA 50% Human Human +DTXSID6049064 Css NA 0.77 mg/L PBTK NA 95% Human Human +DTXSID6049064 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049064 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049064 Vd NA 1.384 L/kg 1compartment NA NA Rat Human DTXSID6049064 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049064 TK.Half.Life NA 0.9778 hours 1compartment NA NA Rat Human -DTXSID6049064 Css NA 0.102 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049064 Css NA 0.4745 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049064 Css NA 0.07203 mg/L PBTK NA 50% Rat Human -DTXSID6049064 Css NA 0.2982 mg/L PBTK NA 95% Rat Human -DTXSID6049066 Clint NA 730.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6049064 TK.Half.Life NA 1.403 hours 1compartment NA NA Rat Human +DTXSID6049064 Css NA 0.01868 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049064 Css NA 0.09658 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049064 Css NA 0.01552 mg/L PBTK NA 50% Rat Human +DTXSID6049064 Css NA 0.06691 mg/L PBTK NA 95% Rat Human +DTXSID6049066 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6049066 Fup 0.013 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6049066 Vd NA 2.998 L/kg 1compartment NA NA Human Human -DTXSID6049066 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049066 TK.Half.Life NA 4.452 hours 1compartment NA NA Human Human -DTXSID6049066 Css NA 0.08744 mg/L 3compartmentss NA 50% Human Human -DTXSID6049066 Css NA 0.5745 mg/L 3compartmentss NA 95% Human Human -DTXSID6049066 Css NA 0.0598 mg/L PBTK NA 50% Human Human -DTXSID6049066 Css NA 0.3852 mg/L PBTK NA 95% Human Human -DTXSID6049066 Clint NA 730.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6049066 Vd NA 3.035 L/kg 1compartment NA NA Human Human +DTXSID6049066 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID6049066 TK.Half.Life NA 74.18 hours 1compartment NA NA Human Human +DTXSID6049066 Css NA 3 mg/L 3compartmentss NA 50% Human Human +DTXSID6049066 Css NA 19.82 mg/L 3compartmentss NA 95% Human Human +DTXSID6049066 Css NA 2.073 mg/L PBTK NA 50% Human Human +DTXSID6049066 Css NA 13.24 mg/L PBTK NA 95% Human Human +DTXSID6049066 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6049066 Fup 0.013 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6049066 Vd NA 2.244 L/kg 1compartment NA NA Rat Human -DTXSID6049066 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049066 TK.Half.Life NA 1.114 hours 1compartment NA NA Rat Human -DTXSID6049066 Css NA 0.0494 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049066 Css NA 0.2699 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049066 Css NA 0.0322 mg/L PBTK NA 50% Rat Human -DTXSID6049066 Css NA 0.1702 mg/L PBTK NA 95% Rat Human -DTXSID6049068 Clint NA 674.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049068 Fup NA 0.0965 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049068 Vd NA 2.375 L/kg 1compartment NA NA Human Human +DTXSID6049066 Vd NA 2.272 L/kg 1compartment NA NA Rat Human +DTXSID6049066 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID6049066 TK.Half.Life NA 11.23 hours 1compartment NA NA Rat Human +DTXSID6049066 Css NA 0.3918 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049066 Css NA 2.158 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049066 Css NA 0.2656 mg/L PBTK NA 50% Rat Human +DTXSID6049066 Css NA 1.429 mg/L PBTK NA 95% Rat Human +DTXSID6049068 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049068 Fup 0.0527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049068 Vd NA 2.021 L/kg 1compartment NA NA Human Human DTXSID6049068 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049068 TK.Half.Life NA 2.194 hours 1compartment NA NA Human Human -DTXSID6049068 Css NA 0.01579 mg/L 3compartmentss NA 50% Human Human -DTXSID6049068 Css NA 0.1139 mg/L 3compartmentss NA 95% Human Human -DTXSID6049068 Css NA 0.0108 mg/L PBTK NA 50% Human Human -DTXSID6049068 Css NA 0.07438 mg/L PBTK NA 95% Human Human -DTXSID6049068 Clint NA 674.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049068 Fup NA 0.0965 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049068 Vd NA 1.791 L/kg 1compartment NA NA Rat Human +DTXSID6049068 TK.Half.Life NA 10.65 hours 1compartment NA NA Human Human +DTXSID6049068 Css NA 0.675 mg/L 3compartmentss NA 50% Human Human +DTXSID6049068 Css NA 4.857 mg/L 3compartmentss NA 95% Human Human +DTXSID6049068 Css NA 0.4442 mg/L PBTK NA 50% Human Human +DTXSID6049068 Css NA 3.045 mg/L PBTK NA 95% Human Human +DTXSID6049068 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049068 Fup 0.0527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049068 Vd NA 1.515 L/kg 1compartment NA NA Rat Human DTXSID6049068 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049068 TK.Half.Life NA 0.7069 hours 1compartment NA NA Rat Human -DTXSID6049068 Css NA 0.008798 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049068 Css NA 0.05332 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049068 Css NA 0.005762 mg/L PBTK NA 50% Rat Human -DTXSID6049068 Css NA 0.03354 mg/L PBTK NA 95% Rat Human -DTXSID6049220 Clint NA 0.09059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049220 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049220 Vd NA 0.7109 L/kg 1compartment NA NA Human Human +DTXSID6049068 TK.Half.Life NA 3.45 hours 1compartment NA NA Rat Human +DTXSID6049068 Css NA 0.08783 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049068 Css NA 0.523 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049068 Css NA 0.05686 mg/L PBTK NA 50% Rat Human +DTXSID6049068 Css NA 0.3199 mg/L PBTK NA 95% Rat Human +DTXSID6049220 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049220 Fup 0.563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049220 Vd NA 0.557 L/kg 1compartment NA NA Human Human DTXSID6049220 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049220 TK.Half.Life NA 4.007 hours 1compartment NA NA Human Human -DTXSID6049220 Css NA 0.7282 mg/L 3compartmentss NA 50% Human Human -DTXSID6049220 Css NA 4.697 mg/L 3compartmentss NA 95% Human Human -DTXSID6049220 Css NA 0.5945 mg/L PBTK NA 50% Human Human -DTXSID6049220 Css NA 3.044 mg/L PBTK NA 95% Human Human -DTXSID6049220 Clint NA 0.09059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049220 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049220 Vd NA 0.7459 L/kg 1compartment NA NA Rat Human +DTXSID6049220 TK.Half.Life NA 6.4 hours 1compartment NA NA Human Human +DTXSID6049220 Css NA 1.145 mg/L 3compartmentss NA 50% Human Human +DTXSID6049220 Css NA 7.898 mg/L 3compartmentss NA 95% Human Human +DTXSID6049220 Css NA 0.8782 mg/L PBTK NA 50% Human Human +DTXSID6049220 Css NA 4.857 mg/L PBTK NA 95% Human Human +DTXSID6049220 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049220 Fup 0.563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049220 Vd NA 0.5822 L/kg 1compartment NA NA Rat Human DTXSID6049220 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049220 TK.Half.Life NA 1.534 hours 1compartment NA NA Rat Human -DTXSID6049220 Css NA 0.2012 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049220 Css NA 1.235 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049220 Css NA 0.161 mg/L PBTK NA 50% Rat Human -DTXSID6049220 Css NA 0.7391 mg/L PBTK NA 95% Rat Human -DTXSID6049222 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049222 Fup NA 0.6804 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049222 Vd NA 2.494 L/kg 1compartment NA NA Human Human -DTXSID6049222 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID6049222 TK.Half.Life NA 56.82 hours 1compartment NA NA Human Human -DTXSID6049222 Css NA 2.2 mg/L 3compartmentss NA 50% Human Human -DTXSID6049222 Css NA 10.02 mg/L 3compartmentss NA 95% Human Human -DTXSID6049222 Css NA 1.984 mg/L PBTK NA 50% Human Human -DTXSID6049222 Css NA 7.034 mg/L PBTK NA 95% Human Human -DTXSID6049222 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049222 Fup NA 0.6804 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049222 Vd NA 1.978 L/kg 1compartment NA NA Rat Human -DTXSID6049222 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6049222 TK.Half.Life NA 8.543 hours 1compartment NA NA Rat Human -DTXSID6049222 Css NA 0.5786 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049222 Css NA 2.455 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049222 Css NA 0.5082 mg/L PBTK NA 50% Rat Human -DTXSID6049222 Css NA 1.591 mg/L PBTK NA 95% Rat Human -DTXSID6049224 Clint NA 41.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049224 Fup NA 0.029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049224 Vd NA 3.099 L/kg 1compartment NA NA Human Human -DTXSID6049224 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID6049224 TK.Half.Life NA 41.46 hours 1compartment NA NA Human Human -DTXSID6049224 Css NA 1.574 mg/L 3compartmentss NA 50% Human Human -DTXSID6049224 Css NA 10.03 mg/L 3compartmentss NA 95% Human Human -DTXSID6049224 Css NA 1.091 mg/L PBTK NA 50% Human Human -DTXSID6049224 Css NA 6.632 mg/L PBTK NA 95% Human Human -DTXSID6049224 Clint NA 41.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049224 Fup NA 0.029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049224 Vd NA 2.322 L/kg 1compartment NA NA Rat Human -DTXSID6049224 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6049224 TK.Half.Life NA 6.017 hours 1compartment NA NA Rat Human -DTXSID6049224 Css NA 0.8912 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049224 Css NA 4.645 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049224 Css NA 0.5883 mg/L PBTK NA 50% Rat Human -DTXSID6049224 Css NA 2.958 mg/L PBTK NA 95% Rat Human -DTXSID6049226 Clint NA 171.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049226 Fup NA 0.0175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049226 Vd NA 3.1 L/kg 1compartment NA NA Human Human -DTXSID6049226 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049226 TK.Half.Life NA 6.94 hours 1compartment NA NA Human Human -DTXSID6049226 Css NA 0.1798 mg/L 3compartmentss NA 50% Human Human -DTXSID6049226 Css NA 1.214 mg/L 3compartmentss NA 95% Human Human -DTXSID6049226 Css NA 0.1256 mg/L PBTK NA 50% Human Human -DTXSID6049226 Css NA 0.8078 mg/L PBTK NA 95% Human Human -DTXSID6049226 Clint NA 171.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049226 Fup NA 0.0175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049226 Vd NA 2.333 L/kg 1compartment NA NA Rat Human -DTXSID6049226 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049226 TK.Half.Life NA 1.45 hours 1compartment NA NA Rat Human -DTXSID6049226 Css NA 0.1014 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049226 Css NA 0.5476 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049226 Css NA 0.06736 mg/L PBTK NA 50% Rat Human -DTXSID6049226 Css NA 0.3458 mg/L PBTK NA 95% Rat Human -DTXSID6049270 Clint NA 0.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049270 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049270 Vd NA 0.3922 L/kg 1compartment NA NA Human Human -DTXSID6049270 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049270 TK.Half.Life NA 6.284 hours 1compartment NA NA Human Human -DTXSID6049270 Css NA 1.89 mg/L 3compartmentss NA 50% Human Human -DTXSID6049270 Css NA 7.592 mg/L 3compartmentss NA 95% Human Human -DTXSID6049270 Css NA 1.269 mg/L PBTK NA 50% Human Human -DTXSID6049270 Css NA 4.668 mg/L PBTK NA 95% Human Human -DTXSID6049270 Clint NA 0.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049270 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049270 Vd NA 0.4019 L/kg 1compartment NA NA Rat Human -DTXSID6049270 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049270 TK.Half.Life NA 2.777 hours 1compartment NA NA Rat Human -DTXSID6049270 Css NA 0.6758 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049270 Css NA 2.202 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049270 Css NA 0.4312 mg/L PBTK NA 50% Rat Human -DTXSID6049270 Css NA 1.267 mg/L PBTK NA 95% Rat Human -DTXSID6049303 Clint NA 28.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049303 Fup NA 0.0304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049303 Vd NA 0.9127 L/kg 1compartment NA NA Human Human +DTXSID6049220 TK.Half.Life NA 2.28 hours 1compartment NA NA Rat Human +DTXSID6049220 Css NA 0.0217 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049220 Css NA 0.1856 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049220 Css NA 0.016 mg/L PBTK NA 50% Rat Human +DTXSID6049220 Css NA 0.1138 mg/L PBTK NA 95% Rat Human +DTXSID6049222 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049222 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049222 Vd NA 1.936 L/kg 1compartment NA NA Human Human +DTXSID6049222 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6049222 TK.Half.Life NA 4.83 hours 1compartment NA NA Human Human +DTXSID6049222 Css NA 0.2297 mg/L 3compartmentss NA 50% Human Human +DTXSID6049222 Css NA 1.702 mg/L 3compartmentss NA 95% Human Human +DTXSID6049222 Css NA 0.1637 mg/L PBTK NA 50% Human Human +DTXSID6049222 Css NA 1.134 mg/L PBTK NA 95% Human Human +DTXSID6049222 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049222 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049222 Vd NA 1.482 L/kg 1compartment NA NA Rat Human +DTXSID6049222 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6049222 TK.Half.Life NA 1.653 hours 1compartment NA NA Rat Human +DTXSID6049222 Css NA 0.02959 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049222 Css NA 0.1661 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049222 Css NA 0.0209 mg/L PBTK NA 50% Rat Human +DTXSID6049222 Css NA 0.1092 mg/L PBTK NA 95% Rat Human +DTXSID6049226 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049226 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049226 Vd NA 3.097 L/kg 1compartment NA NA Human Human +DTXSID6049226 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6049226 TK.Half.Life NA 30.43 hours 1compartment NA NA Human Human +DTXSID6049226 Css NA 1.102 mg/L 3compartmentss NA 50% Human Human +DTXSID6049226 Css NA 7.194 mg/L 3compartmentss NA 95% Human Human +DTXSID6049226 Css NA 0.7735 mg/L PBTK NA 50% Human Human +DTXSID6049226 Css NA 4.868 mg/L PBTK NA 95% Human Human +DTXSID6049226 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049226 Fup 0.0352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049226 Vd NA 2.346 L/kg 1compartment NA NA Rat Human +DTXSID6049226 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6049226 TK.Half.Life NA 4.997 hours 1compartment NA NA Rat Human +DTXSID6049226 Css NA 0.145 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049226 Css NA 0.8274 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049226 Css NA 0.101 mg/L PBTK NA 50% Rat Human +DTXSID6049226 Css NA 0.566 mg/L PBTK NA 95% Rat Human +DTXSID6049278 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049278 Fup 0.0677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049278 Vd NA 1.302 L/kg 1compartment NA NA Human Human +DTXSID6049278 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6049278 TK.Half.Life NA 4.712 hours 1compartment NA NA Human Human +DTXSID6049278 Css NA 0.4592 mg/L 3compartmentss NA 50% Human Human +DTXSID6049278 Css NA 3.41 mg/L 3compartmentss NA 95% Human Human +DTXSID6049278 Css NA 0.2951 mg/L PBTK NA 50% Human Human +DTXSID6049278 Css NA 2.092 mg/L PBTK NA 95% Human Human +DTXSID6049278 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049278 Fup 0.0677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049278 Vd NA 0.991 L/kg 1compartment NA NA Rat Human +DTXSID6049278 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6049278 TK.Half.Life NA 1.918 hours 1compartment NA NA Rat Human +DTXSID6049278 Css NA 0.05997 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049278 Css NA 0.3586 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049278 Css NA 0.0375 mg/L PBTK NA 50% Rat Human +DTXSID6049278 Css NA 0.2154 mg/L PBTK NA 95% Rat Human +DTXSID6049303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049303 Fup 0.0958 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049303 Vd NA 1.396 L/kg 1compartment NA NA Human Human DTXSID6049303 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049303 TK.Half.Life NA 4.59 hours 1compartment NA NA Human Human -DTXSID6049303 Css NA 0.7525 mg/L 3compartmentss NA 50% Human Human -DTXSID6049303 Css NA 7.226 mg/L 3compartmentss NA 95% Human Human -DTXSID6049303 Css NA 0.4604 mg/L PBTK NA 50% Human Human -DTXSID6049303 Css NA 4.257 mg/L PBTK NA 95% Human Human -DTXSID6049303 Clint NA 28.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049303 Fup NA 0.0304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049303 Vd NA 0.6897 L/kg 1compartment NA NA Rat Human +DTXSID6049303 TK.Half.Life NA 4.007 hours 1compartment NA NA Human Human +DTXSID6049303 Css NA 0.3157 mg/L 3compartmentss NA 50% Human Human +DTXSID6049303 Css NA 2.433 mg/L 3compartmentss NA 95% Human Human +DTXSID6049303 Css NA 0.207 mg/L PBTK NA 50% Human Human +DTXSID6049303 Css NA 1.528 mg/L PBTK NA 95% Human Human +DTXSID6049303 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049303 Fup 0.0958 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049303 Vd NA 1.071 L/kg 1compartment NA NA Rat Human DTXSID6049303 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049303 TK.Half.Life NA 2.045 hours 1compartment NA NA Rat Human -DTXSID6049303 Css NA 0.4327 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049303 Css NA 3.165 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049303 Css NA 0.2478 mg/L PBTK NA 50% Rat Human -DTXSID6049303 Css NA 1.757 mg/L PBTK NA 95% Rat Human -DTXSID6049307 Clint NA 1.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049307 Fup NA 0.0897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049307 Vd NA 2.571 L/kg 1compartment NA NA Human Human -DTXSID6049307 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID6049307 TK.Half.Life NA 108.3 hours 1compartment NA NA Human Human -DTXSID6049307 Css NA 5.655 mg/L 3compartmentss NA 50% Human Human -DTXSID6049307 Css NA 24.99 mg/L 3compartmentss NA 95% Human Human -DTXSID6049307 Css NA 3.878 mg/L PBTK NA 50% Human Human -DTXSID6049307 Css NA 16.12 mg/L PBTK NA 95% Human Human -DTXSID6049307 Clint NA 1.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049307 Fup NA 0.0897 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049307 Vd NA 1.934 L/kg 1compartment NA NA Rat Human -DTXSID6049307 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID6049307 TK.Half.Life NA 22.28 hours 1compartment NA NA Rat Human -DTXSID6049307 Css NA 2.702 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049307 Css NA 8.588 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049307 Css NA 1.768 mg/L PBTK NA 50% Rat Human -DTXSID6049307 Css NA 5.193 mg/L PBTK NA 95% Rat Human -DTXSID6049309 Clint NA 45.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049309 Fup NA 0.2718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049309 Vd NA 1.733 L/kg 1compartment NA NA Human Human -DTXSID6049309 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049309 TK.Half.Life NA 1.675 hours 1compartment NA NA Human Human -DTXSID6049309 Css NA 0.03495 mg/L 3compartmentss NA 50% Human Human -DTXSID6049309 Css NA 0.2699 mg/L 3compartmentss NA 95% Human Human -DTXSID6049309 Css NA 0.02904 mg/L PBTK NA 50% Human Human -DTXSID6049309 Css NA 0.2003 mg/L PBTK NA 95% Human Human -DTXSID6049309 Clint NA 45.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049309 Fup NA 0.2718 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049309 Vd NA 1.642 L/kg 1compartment NA NA Rat Human -DTXSID6049309 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049309 TK.Half.Life NA 0.7948 hours 1compartment NA NA Rat Human -DTXSID6049309 Css NA 0.01876 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049309 Css NA 0.1162 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049309 Css NA 0.01518 mg/L PBTK NA 50% Rat Human -DTXSID6049309 Css NA 0.08357 mg/L PBTK NA 95% Rat Human -DTXSID6049351 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049351 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049351 Vd NA 534100 L/kg 1compartment NA NA Human Human -DTXSID6049351 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID6049351 TK.Half.Life NA 504100 hours 1compartment NA NA Human Human -DTXSID6049351 Css NA 7.28e-07 mg/L 3compartmentss NA 50% Human Human -DTXSID6049351 Css NA 4.386e-06 mg/L 3compartmentss NA 95% Human Human -DTXSID6049351 Css NA 0.07869 mg/L PBTK NA 50% Human Human -DTXSID6049351 Css NA 0.4336 mg/L PBTK NA 95% Human Human -DTXSID6049351 Clint NA 691.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049351 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049351 Vd NA 509800 L/kg 1compartment NA NA Rat Human -DTXSID6049351 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID6049351 TK.Half.Life NA 88300 hours 1compartment NA NA Rat Human -DTXSID6049351 Css NA 3.67e-07 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049351 Css NA 1.636e-06 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049351 Css NA 0.04275 mg/L PBTK NA 50% Rat Human -DTXSID6049351 Css NA 0.1912 mg/L PBTK NA 95% Rat Human -DTXSID6049357 Clint NA 5.971 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049357 Fup NA 0.057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049357 Vd NA 2.183 L/kg 1compartment NA NA Human Human -DTXSID6049357 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6049357 TK.Half.Life NA 36.08 hours 1compartment NA NA Human Human -DTXSID6049357 Css NA 2.387 mg/L 3compartmentss NA 50% Human Human -DTXSID6049357 Css NA 14.15 mg/L 3compartmentss NA 95% Human Human -DTXSID6049357 Css NA 1.586 mg/L PBTK NA 50% Human Human -DTXSID6049357 Css NA 8.904 mg/L PBTK NA 95% Human Human -DTXSID6049357 Clint NA 5.971 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049357 Fup NA 0.057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049357 Vd NA 1.638 L/kg 1compartment NA NA Rat Human -DTXSID6049357 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6049357 TK.Half.Life NA 10.35 hours 1compartment NA NA Rat Human -DTXSID6049357 Css NA 1.268 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049357 Css NA 5.397 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049357 Css NA 0.7986 mg/L PBTK NA 50% Rat Human -DTXSID6049357 Css NA 3.282 mg/L PBTK NA 95% Rat Human -DTXSID6049359 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049359 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049359 Vd NA 3.157 L/kg 1compartment NA NA Human Human -DTXSID6049359 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049359 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human -DTXSID6049359 Css NA 0.3557 mg/L 3compartmentss NA 50% Human Human -DTXSID6049359 Css NA 2.326 mg/L 3compartmentss NA 95% Human Human -DTXSID6049359 Css NA 0.2508 mg/L PBTK NA 50% Human Human -DTXSID6049359 Css NA 1.568 mg/L PBTK NA 95% Human Human -DTXSID6049359 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049359 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049359 Vd NA 2.375 L/kg 1compartment NA NA Rat Human -DTXSID6049359 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049359 TK.Half.Life NA 2.005 hours 1compartment NA NA Rat Human -DTXSID6049359 Css NA 0.199 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049359 Css NA 1.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049359 Css NA 0.1344 mg/L PBTK NA 50% Rat Human -DTXSID6049359 Css NA 0.7061 mg/L PBTK NA 95% Rat Human -DTXSID6049432 Clint NA 3.474 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049432 Fup NA 0.5047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6049432 Vd NA 1.101 L/kg 1compartment NA NA Human Human +DTXSID6049303 TK.Half.Life NA 1.595 hours 1compartment NA NA Rat Human +DTXSID6049303 Css NA 0.0408 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049303 Css NA 0.2446 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049303 Css NA 0.02628 mg/L PBTK NA 50% Rat Human +DTXSID6049303 Css NA 0.1483 mg/L PBTK NA 95% Rat Human +DTXSID6049307 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049307 Fup 0.023 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049307 Vd NA 1.742 L/kg 1compartment NA NA Human Human +DTXSID6049307 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6049307 TK.Half.Life NA 15.16 hours 1compartment NA NA Human Human +DTXSID6049307 Css NA 1.288 mg/L 3compartmentss NA 50% Human Human +DTXSID6049307 Css NA 11.65 mg/L 3compartmentss NA 95% Human Human +DTXSID6049307 Css NA 0.821 mg/L PBTK NA 50% Human Human +DTXSID6049307 Css NA 7.189 mg/L PBTK NA 95% Human Human +DTXSID6049307 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049307 Fup 0.023 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049307 Vd NA 1.295 L/kg 1compartment NA NA Rat Human +DTXSID6049307 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6049307 TK.Half.Life NA 5.398 hours 1compartment NA NA Rat Human +DTXSID6049307 Css NA 0.1705 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049307 Css NA 1.161 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049307 Css NA 0.1052 mg/L PBTK NA 50% Rat Human +DTXSID6049307 Css NA 0.6949 mg/L PBTK NA 95% Rat Human +DTXSID6049309 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049309 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049309 Vd NA 2.177 L/kg 1compartment NA NA Human Human +DTXSID6049309 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID6049309 TK.Half.Life NA 39.18 hours 1compartment NA NA Human Human +DTXSID6049309 Css NA 1.551 mg/L 3compartmentss NA 50% Human Human +DTXSID6049309 Css NA 7.44 mg/L 3compartmentss NA 95% Human Human +DTXSID6049309 Css NA 1.444 mg/L PBTK NA 50% Human Human +DTXSID6049309 Css NA 5.292 mg/L PBTK NA 95% Human Human +DTXSID6049309 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049309 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049309 Vd NA 2.079 L/kg 1compartment NA NA Rat Human +DTXSID6049309 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6049309 TK.Half.Life NA 11.74 hours 1compartment NA NA Rat Human +DTXSID6049309 Css NA 0.09629 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049309 Css NA 0.4118 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049309 Css NA 0.0911 mg/L PBTK NA 50% Rat Human +DTXSID6049309 Css NA 0.2818 mg/L PBTK NA 95% Rat Human +DTXSID6049357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049357 Fup 0.0222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049357 Vd NA 1.601 L/kg 1compartment NA NA Human Human +DTXSID6049357 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6049357 TK.Half.Life NA 13.9 hours 1compartment NA NA Human Human +DTXSID6049357 Css NA 1.342 mg/L 3compartmentss NA 50% Human Human +DTXSID6049357 Css NA 12.18 mg/L 3compartmentss NA 95% Human Human +DTXSID6049357 Css NA 0.8434 mg/L PBTK NA 50% Human Human +DTXSID6049357 Css NA 7.344 mg/L PBTK NA 95% Human Human +DTXSID6049357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049357 Fup 0.0222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049357 Vd NA 1.189 L/kg 1compartment NA NA Rat Human +DTXSID6049357 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6049357 TK.Half.Life NA 5.188 hours 1compartment NA NA Rat Human +DTXSID6049357 Css NA 0.1708 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049357 Css NA 1.185 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049357 Css NA 0.1049 mg/L PBTK NA 50% Rat Human +DTXSID6049357 Css NA 0.695 mg/L PBTK NA 95% Rat Human +DTXSID6049430 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049430 Fup 0.0895 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049430 Vd NA 1.778 L/kg 1compartment NA NA Human Human +DTXSID6049430 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6049430 TK.Half.Life NA 5.889 hours 1compartment NA NA Human Human +DTXSID6049430 Css NA 0.3716 mg/L 3compartmentss NA 50% Human Human +DTXSID6049430 Css NA 2.652 mg/L 3compartmentss NA 95% Human Human +DTXSID6049430 Css NA 0.2477 mg/L PBTK NA 50% Human Human +DTXSID6049430 Css NA 1.671 mg/L PBTK NA 95% Human Human +DTXSID6049430 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049430 Fup 0.0895 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049430 Vd NA 1.348 L/kg 1compartment NA NA Rat Human +DTXSID6049430 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6049430 TK.Half.Life NA 2.104 hours 1compartment NA NA Rat Human +DTXSID6049430 Css NA 0.04815 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049430 Css NA 0.2737 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049430 Css NA 0.03141 mg/L PBTK NA 50% Rat Human +DTXSID6049430 Css NA 0.1718 mg/L PBTK NA 95% Rat Human +DTXSID6049432 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049432 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6049432 Vd NA 0.8661 L/kg 1compartment NA NA Human Human DTXSID6049432 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6049432 TK.Half.Life NA 2.72 hours 1compartment NA NA Human Human -DTXSID6049432 Css NA 0.215 mg/L 3compartmentss NA 50% Human Human -DTXSID6049432 Css NA 1.44 mg/L 3compartmentss NA 95% Human Human -DTXSID6049432 Css NA 0.1773 mg/L PBTK NA 50% Human Human -DTXSID6049432 Css NA 0.9897 mg/L PBTK NA 95% Human Human -DTXSID6049432 Clint NA 3.474 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049432 Fup NA 0.5047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6049432 Vd NA 0.9863 L/kg 1compartment NA NA Rat Human +DTXSID6049432 TK.Half.Life NA 2.051 hours 1compartment NA NA Human Human +DTXSID6049432 Css NA 0.1991 mg/L 3compartmentss NA 50% Human Human +DTXSID6049432 Css NA 1.269 mg/L 3compartmentss NA 95% Human Human +DTXSID6049432 Css NA 0.1479 mg/L PBTK NA 50% Human Human +DTXSID6049432 Css NA 0.8551 mg/L PBTK NA 95% Human Human +DTXSID6049432 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049432 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6049432 Vd NA 0.773 L/kg 1compartment NA NA Rat Human DTXSID6049432 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6049432 TK.Half.Life NA 1.286 hours 1compartment NA NA Rat Human -DTXSID6049432 Css NA 0.1022 mg/L 3compartmentss NA 50% Rat Human -DTXSID6049432 Css NA 0.5882 mg/L 3compartmentss NA 95% Rat Human -DTXSID6049432 Css NA 0.08139 mg/L PBTK NA 50% Rat Human -DTXSID6049432 Css NA 0.3711 mg/L PBTK NA 95% Rat Human -DTXSID6051306 Clint NA 140.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051306 Fup NA 0.0057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051306 Vd NA 68.51 L/kg 1compartment NA NA Human Human -DTXSID6051306 Days.Css NA 65 Days PBTK NA NA Human Human -DTXSID6051306 TK.Half.Life NA 321.1 hours 1compartment NA NA Human Human -DTXSID6051306 Css NA 0.0492 mg/L 3compartmentss NA 50% Human Human -DTXSID6051306 Css NA 0.3028 mg/L 3compartmentss NA 95% Human Human -DTXSID6051306 Css NA 0.3857 mg/L PBTK NA 50% Human Human -DTXSID6051306 Css NA 2.179 mg/L PBTK NA 95% Human Human -DTXSID6051306 Clint NA 140.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051306 Fup NA 0.0057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051306 Vd NA 58.45 L/kg 1compartment NA NA Rat Human -DTXSID6051306 Days.Css NA 44 Days PBTK NA NA Rat Human -DTXSID6051306 TK.Half.Life NA 50.3 hours 1compartment NA NA Rat Human -DTXSID6051306 Css NA 0.02517 mg/L 3compartmentss NA 50% Rat Human -DTXSID6051306 Css NA 0.1032 mg/L 3compartmentss NA 95% Rat Human -DTXSID6051306 Css NA 0.2096 mg/L PBTK NA 50% Rat Human -DTXSID6051306 Css NA 0.877 mg/L PBTK NA 95% Rat Human +DTXSID6049432 TK.Half.Life NA 1.015 hours 1compartment NA NA Rat Human +DTXSID6049432 Css NA 0.02344 mg/L 3compartmentss NA 50% Rat Human +DTXSID6049432 Css NA 0.1115 mg/L 3compartmentss NA 95% Rat Human +DTXSID6049432 Css NA 0.01729 mg/L PBTK NA 50% Rat Human +DTXSID6049432 Css NA 0.07305 mg/L PBTK NA 95% Rat Human +DTXSID6051306 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051306 Fup 0.00718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051306 Vd NA 32.92 L/kg 1compartment NA NA Human Human +DTXSID6051306 Days.Css NA 238 Days PBTK NA NA Human Human +DTXSID6051306 TK.Half.Life NA 983.2 hours 1compartment NA NA Human Human +DTXSID6051306 Css NA 0.6869 mg/L 3compartmentss NA 50% Human Human +DTXSID6051306 Css NA 4.367 mg/L 3compartmentss NA 95% Human Human +DTXSID6051306 Css NA 2.407 mg/L PBTK NA 50% Human Human +DTXSID6051306 Css NA 14.28 mg/L PBTK NA 95% Human Human +DTXSID6051306 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051306 Fup 0.00718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051306 Vd NA 27.3 L/kg 1compartment NA NA Rat Human +DTXSID6051306 Days.Css NA 146 Days PBTK NA NA Rat Human +DTXSID6051306 TK.Half.Life NA 145.6 hours 1compartment NA NA Rat Human +DTXSID6051306 Css NA 0.08324 mg/L 3compartmentss NA 50% Rat Human +DTXSID6051306 Css NA 0.39 mg/L 3compartmentss NA 95% Rat Human +DTXSID6051306 Css NA 0.3143 mg/L PBTK NA 50% Rat Human +DTXSID6051306 Css NA 1.605 mg/L PBTK NA 95% Rat Human DTXSID6051560 Clint NA 1.058 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6051560 Fup NA 0.8004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051560 Vd NA 0.9323 L/kg 1compartment NA NA Human Human +DTXSID6051560 Vd NA 1.144 L/kg 1compartment NA NA Human Human DTXSID6051560 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6051560 TK.Half.Life NA 2.983 hours 1compartment NA NA Human Human -DTXSID6051560 Css NA 0.3534 mg/L 3compartmentss NA 50% Human Human -DTXSID6051560 Css NA 2.297 mg/L 3compartmentss NA 95% Human Human -DTXSID6051560 Css NA 0.3006 mg/L PBTK NA 50% Human Human -DTXSID6051560 Css NA 1.519 mg/L PBTK NA 95% Human Human +DTXSID6051560 TK.Half.Life NA 3.713 hours 1compartment NA NA Human Human +DTXSID6051560 Css NA 0.2859 mg/L 3compartmentss NA 50% Human Human +DTXSID6051560 Css NA 1.964 mg/L 3compartmentss NA 95% Human Human +DTXSID6051560 Css NA 0.2523 mg/L PBTK NA 50% Human Human +DTXSID6051560 Css NA 1.322 mg/L PBTK NA 95% Human Human DTXSID6051560 Clint NA 1.058 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6051560 Fup NA 0.8004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051560 Vd NA 0.934 L/kg 1compartment NA NA Rat Human +DTXSID6051560 Vd NA 1.103 L/kg 1compartment NA NA Rat Human DTXSID6051560 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6051560 TK.Half.Life NA 1.443 hours 1compartment NA NA Rat Human -DTXSID6051560 Css NA 0.1343 mg/L 3compartmentss NA 50% Rat Human -DTXSID6051560 Css NA 0.8441 mg/L 3compartmentss NA 95% Rat Human -DTXSID6051560 Css NA 0.1131 mg/L PBTK NA 50% Rat Human -DTXSID6051560 Css NA 0.5126 mg/L PBTK NA 95% Rat Human +DTXSID6051560 TK.Half.Life NA 1.706 hours 1compartment NA NA Rat Human +DTXSID6051560 Css NA 0.007862 mg/L 3compartmentss NA 50% Rat Human +DTXSID6051560 Css NA 0.07104 mg/L 3compartmentss NA 95% Rat Human +DTXSID6051560 Css NA 0.006752 mg/L PBTK NA 50% Rat Human +DTXSID6051560 Css NA 0.04749 mg/L PBTK NA 95% Rat Human +DTXSID6051564 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051564 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051564 Vd NA 0.9148 L/kg 1compartment NA NA Human Human +DTXSID6051564 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6051564 TK.Half.Life NA 2.213 hours 1compartment NA NA Human Human +DTXSID6051564 Css NA 0.1759 mg/L 3compartmentss NA 50% Human Human +DTXSID6051564 Css NA 1.118 mg/L 3compartmentss NA 95% Human Human +DTXSID6051564 Css NA 0.1304 mg/L PBTK NA 50% Human Human +DTXSID6051564 Css NA 0.7571 mg/L PBTK NA 95% Human Human +DTXSID6051564 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051564 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051564 Vd NA 0.8057 L/kg 1compartment NA NA Rat Human +DTXSID6051564 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6051564 TK.Half.Life NA 1.076 hours 1compartment NA NA Rat Human +DTXSID6051564 Css NA 0.005767 mg/L 3compartmentss NA 50% Rat Human +DTXSID6051564 Css NA 0.04625 mg/L 3compartmentss NA 95% Rat Human +DTXSID6051564 Css NA 0.004241 mg/L PBTK NA 50% Rat Human +DTXSID6051564 Css NA 0.0303 mg/L PBTK NA 95% Rat Human DTXSID6051566 Clint NA 7.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6051566 Fup NA 0.1276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051566 Vd NA 54.72 L/kg 1compartment NA NA Human Human -DTXSID6051566 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID6051566 TK.Half.Life NA 4683 hours 1compartment NA NA Human Human -DTXSID6051566 Css NA 1.15 mg/L 3compartmentss NA 50% Human Human -DTXSID6051566 Css NA 7.041 mg/L 3compartmentss NA 95% Human Human -DTXSID6051566 Css NA 7.053 mg/L PBTK NA 50% Human Human -DTXSID6051566 Css NA 40.04 mg/L PBTK NA 95% Human Human +DTXSID6051566 Vd NA 0.3024 L/kg 1compartment NA NA Human Human +DTXSID6051566 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6051566 TK.Half.Life NA 1.39 hours 1compartment NA NA Human Human +DTXSID6051566 Css NA 0.606 mg/L 3compartmentss NA 50% Human Human +DTXSID6051566 Css NA 4.329 mg/L 3compartmentss NA 95% Human Human +DTXSID6051566 Css NA 0.3761 mg/L PBTK NA 50% Human Human +DTXSID6051566 Css NA 2.591 mg/L PBTK NA 95% Human Human DTXSID6051566 Clint NA 7.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6051566 Fup NA 0.1276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051566 Vd NA 46.29 L/kg 1compartment NA NA Rat Human -DTXSID6051566 Days.Css NA 757 Days PBTK NA NA Rat Human -DTXSID6051566 TK.Half.Life NA 664.6 hours 1compartment NA NA Rat Human -DTXSID6051566 Css NA 0.5891 mg/L 3compartmentss NA 50% Rat Human -DTXSID6051566 Css NA 2.54 mg/L 3compartmentss NA 95% Rat Human -DTXSID6051566 Css NA 3.82 mg/L PBTK NA 50% Rat Human -DTXSID6051566 Css NA 16.74 mg/L PBTK NA 95% Rat Human -DTXSID6051695 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051695 Fup NA 0.423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051695 Vd NA 2.86 L/kg 1compartment NA NA Human Human -DTXSID6051695 Days.Css NA 47 Days PBTK NA NA Human Human -DTXSID6051695 TK.Half.Life NA 225.9 hours 1compartment NA NA Human Human -DTXSID6051695 Css NA 8.475 mg/L 3compartmentss NA 50% Human Human -DTXSID6051695 Css NA 25.81 mg/L 3compartmentss NA 95% Human Human -DTXSID6051695 Css NA 6.412 mg/L PBTK NA 50% Human Human -DTXSID6051695 Css NA 17.5 mg/L PBTK NA 95% Human Human -DTXSID6051695 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051695 Fup NA 0.423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051695 Vd NA 2.188 L/kg 1compartment NA NA Rat Human -DTXSID6051695 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID6051695 TK.Half.Life NA 22.73 hours 1compartment NA NA Rat Human -DTXSID6051695 Css NA 2.288 mg/L 3compartmentss NA 50% Rat Human -DTXSID6051695 Css NA 5.463 mg/L 3compartmentss NA 95% Rat Human -DTXSID6051695 Css NA 1.672 mg/L PBTK NA 50% Rat Human -DTXSID6051695 Css NA 3.454 mg/L PBTK NA 95% Rat Human -DTXSID6051724 Clint NA 12.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051724 Fup NA 0.1753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051724 Vd NA 0.2875 L/kg 1compartment NA NA Human Human +DTXSID6051566 Vd NA 0.3047 L/kg 1compartment NA NA Rat Human +DTXSID6051566 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6051566 TK.Half.Life NA 0.8461 hours 1compartment NA NA Rat Human +DTXSID6051566 Css NA 0.07566 mg/L 3compartmentss NA 50% Rat Human +DTXSID6051566 Css NA 0.3927 mg/L 3compartmentss NA 95% Rat Human +DTXSID6051566 Css NA 0.04583 mg/L PBTK NA 50% Rat Human +DTXSID6051566 Css NA 0.2266 mg/L PBTK NA 95% Rat Human +DTXSID6051643 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051643 Fup 0.0166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051643 Vd NA 2.743 L/kg 1compartment NA NA Human Human +DTXSID6051643 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID6051643 TK.Half.Life NA 44.01 hours 1compartment NA NA Human Human +DTXSID6051643 Css NA 2.149 mg/L 3compartmentss NA 50% Human Human +DTXSID6051643 Css NA 15.56 mg/L 3compartmentss NA 95% Human Human +DTXSID6051643 Css NA 1.44 mg/L PBTK NA 50% Human Human +DTXSID6051643 Css NA 9.928 mg/L PBTK NA 95% Human Human +DTXSID6051643 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051643 Fup 0.0166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051643 Vd NA 2.051 L/kg 1compartment NA NA Rat Human +DTXSID6051643 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6051643 TK.Half.Life NA 9.038 hours 1compartment NA NA Rat Human +DTXSID6051643 Css NA 0.2768 mg/L 3compartmentss NA 50% Rat Human +DTXSID6051643 Css NA 1.688 mg/L 3compartmentss NA 95% Rat Human +DTXSID6051643 Css NA 0.1834 mg/L PBTK NA 50% Rat Human +DTXSID6051643 Css NA 1.065 mg/L PBTK NA 95% Rat Human +DTXSID6051724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051724 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051724 Vd NA 0.3219 L/kg 1compartment NA NA Human Human DTXSID6051724 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6051724 TK.Half.Life NA 0.7254 hours 1compartment NA NA Human Human -DTXSID6051724 Css NA 0.2434 mg/L 3compartmentss NA 50% Human Human -DTXSID6051724 Css NA 1.603 mg/L 3compartmentss NA 95% Human Human -DTXSID6051724 Css NA 0.1521 mg/L PBTK NA 50% Human Human -DTXSID6051724 Css NA 0.9773 mg/L PBTK NA 95% Human Human -DTXSID6051724 Clint NA 12.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051724 Fup NA 0.1753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051724 Vd NA 0.2896 L/kg 1compartment NA NA Rat Human +DTXSID6051724 TK.Half.Life NA 1.217 hours 1compartment NA NA Human Human +DTXSID6051724 Css NA 0.3998 mg/L 3compartmentss NA 50% Human Human +DTXSID6051724 Css NA 2.376 mg/L 3compartmentss NA 95% Human Human +DTXSID6051724 Css NA 0.2557 mg/L PBTK NA 50% Human Human +DTXSID6051724 Css NA 1.433 mg/L PBTK NA 95% Human Human +DTXSID6051724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051724 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051724 Vd NA 0.3186 L/kg 1compartment NA NA Rat Human DTXSID6051724 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6051724 TK.Half.Life NA 0.425 hours 1compartment NA NA Rat Human -DTXSID6051724 Css NA 0.1336 mg/L 3compartmentss NA 50% Rat Human -DTXSID6051724 Css NA 0.6293 mg/L 3compartmentss NA 95% Rat Human -DTXSID6051724 Css NA 0.0792 mg/L PBTK NA 50% Rat Human -DTXSID6051724 Css NA 0.3594 mg/L PBTK NA 95% Rat Human -DTXSID6051778 Clint NA 20.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051778 Fup NA 0.193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6051778 Vd NA 0.5561 L/kg 1compartment NA NA Human Human -DTXSID6051778 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6051778 TK.Half.Life NA 0.9658 hours 1compartment NA NA Human Human -DTXSID6051778 Css NA 0.125 mg/L 3compartmentss NA 50% Human Human -DTXSID6051778 Css NA 0.8461 mg/L 3compartmentss NA 95% Human Human -DTXSID6051778 Css NA 0.08364 mg/L PBTK NA 50% Human Human -DTXSID6051778 Css NA 0.5413 mg/L PBTK NA 95% Human Human -DTXSID6051778 Clint NA 20.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051778 Fup NA 0.193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6051778 Vd NA 0.5091 L/kg 1compartment NA NA Rat Human +DTXSID6051724 TK.Half.Life NA 0.7085 hours 1compartment NA NA Rat Human +DTXSID6051724 Css NA 0.04812 mg/L 3compartmentss NA 50% Rat Human +DTXSID6051724 Css NA 0.2018 mg/L 3compartmentss NA 95% Rat Human +DTXSID6051724 Css NA 0.02998 mg/L PBTK NA 50% Rat Human +DTXSID6051724 Css NA 0.1213 mg/L PBTK NA 95% Rat Human +DTXSID6051774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051774 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051774 Vd NA 1.35 L/kg 1compartment NA NA Human Human +DTXSID6051774 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6051774 TK.Half.Life NA 3.25 hours 1compartment NA NA Human Human +DTXSID6051774 Css NA 0.237 mg/L 3compartmentss NA 50% Human Human +DTXSID6051774 Css NA 1.781 mg/L 3compartmentss NA 95% Human Human +DTXSID6051774 Css NA 0.1586 mg/L PBTK NA 50% Human Human +DTXSID6051774 Css NA 1.149 mg/L PBTK NA 95% Human Human +DTXSID6051774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051774 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051774 Vd NA 1.048 L/kg 1compartment NA NA Rat Human +DTXSID6051774 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6051774 TK.Half.Life NA 1.31 hours 1compartment NA NA Rat Human +DTXSID6051774 Css NA 0.03063 mg/L 3compartmentss NA 50% Rat Human +DTXSID6051774 Css NA 0.1852 mg/L 3compartmentss NA 95% Rat Human +DTXSID6051774 Css NA 0.02014 mg/L PBTK NA 50% Rat Human +DTXSID6051774 Css NA 0.1124 mg/L PBTK NA 95% Rat Human +DTXSID6051778 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051778 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6051778 Vd NA 0.7034 L/kg 1compartment NA NA Human Human +DTXSID6051778 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6051778 TK.Half.Life NA 15.9 hours 1compartment NA NA Human Human +DTXSID6051778 Css NA 2.497 mg/L 3compartmentss NA 50% Human Human +DTXSID6051778 Css NA 9.961 mg/L 3compartmentss NA 95% Human Human +DTXSID6051778 Css NA 1.814 mg/L PBTK NA 50% Human Human +DTXSID6051778 Css NA 6.312 mg/L PBTK NA 95% Human Human +DTXSID6051778 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051778 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6051778 Vd NA 0.6446 L/kg 1compartment NA NA Rat Human DTXSID6051778 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6051778 TK.Half.Life NA 0.4909 hours 1compartment NA NA Rat Human -DTXSID6051778 Css NA 0.06729 mg/L 3compartmentss NA 50% Rat Human -DTXSID6051778 Css NA 0.3381 mg/L 3compartmentss NA 95% Rat Human -DTXSID6051778 Css NA 0.04288 mg/L PBTK NA 50% Rat Human -DTXSID6051778 Css NA 0.2058 mg/L PBTK NA 95% Rat Human -DTXSID6052291 Clint NA 3.186 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052291 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052291 Vd NA 1.583 L/kg 1compartment NA NA Human Human -DTXSID6052291 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6052291 TK.Half.Life NA 2.185 hours 1compartment NA NA Human Human -DTXSID6052291 Css NA 0.1226 mg/L 3compartmentss NA 50% Human Human -DTXSID6052291 Css NA 1.109 mg/L 3compartmentss NA 95% Human Human -DTXSID6052291 Css NA 0.1155 mg/L PBTK NA 50% Human Human -DTXSID6052291 Css NA 0.8069 mg/L PBTK NA 95% Human Human -DTXSID6052291 Clint NA 3.186 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052291 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052291 Vd NA 1.606 L/kg 1compartment NA NA Rat Human -DTXSID6052291 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6052291 TK.Half.Life NA 1.172 hours 1compartment NA NA Rat Human -DTXSID6052291 Css NA 0.05313 mg/L 3compartmentss NA 50% Rat Human -DTXSID6052291 Css NA 0.4045 mg/L 3compartmentss NA 95% Rat Human -DTXSID6052291 Css NA 0.05068 mg/L PBTK NA 50% Rat Human -DTXSID6052291 Css NA 0.2626 mg/L PBTK NA 95% Rat Human -DTXSID6052295 Clint NA 2.711 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052295 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052295 Vd NA 2.95 L/kg 1compartment NA NA Human Human -DTXSID6052295 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6052295 TK.Half.Life NA 4.245 hours 1compartment NA NA Human Human -DTXSID6052295 Css NA 0.1153 mg/L 3compartmentss NA 50% Human Human -DTXSID6052295 Css NA 1.151 mg/L 3compartmentss NA 95% Human Human -DTXSID6052295 Css NA 0.1319 mg/L PBTK NA 50% Human Human -DTXSID6052295 Css NA 0.8807 mg/L PBTK NA 95% Human Human -DTXSID6052295 Clint NA 2.711 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052295 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052295 Vd NA 3.007 L/kg 1compartment NA NA Rat Human +DTXSID6051778 TK.Half.Life NA 4.864 hours 1compartment NA NA Rat Human +DTXSID6051778 Css NA 0.1604 mg/L 3compartmentss NA 50% Rat Human +DTXSID6051778 Css NA 0.5248 mg/L 3compartmentss NA 95% Rat Human +DTXSID6051778 Css NA 0.114 mg/L PBTK NA 50% Rat Human +DTXSID6051778 Css NA 0.3216 mg/L PBTK NA 95% Rat Human +DTXSID6052295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052295 Fup 0.778 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052295 Vd NA 2.472 L/kg 1compartment NA NA Human Human +DTXSID6052295 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6052295 TK.Half.Life NA 20.59 hours 1compartment NA NA Human Human +DTXSID6052295 Css NA 0.6552 mg/L 3compartmentss NA 50% Human Human +DTXSID6052295 Css NA 4.971 mg/L 3compartmentss NA 95% Human Human +DTXSID6052295 Css NA 0.7096 mg/L PBTK NA 50% Human Human +DTXSID6052295 Css NA 3.462 mg/L PBTK NA 95% Human Human +DTXSID6052295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052295 Fup 0.778 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052295 Vd NA 2.512 L/kg 1compartment NA NA Rat Human DTXSID6052295 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6052295 TK.Half.Life NA 2.323 hours 1compartment NA NA Rat Human -DTXSID6052295 Css NA 0.0482 mg/L 3compartmentss NA 50% Rat Human -DTXSID6052295 Css NA 0.3989 mg/L 3compartmentss NA 95% Rat Human -DTXSID6052295 Css NA 0.05683 mg/L PBTK NA 50% Rat Human -DTXSID6052295 Css NA 0.2777 mg/L PBTK NA 95% Rat Human -DTXSID6052328 Clint NA 2.256 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052328 Fup NA 0.3169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052328 Vd NA 1.546 L/kg 1compartment NA NA Human Human +DTXSID6052295 TK.Half.Life NA 7.122 hours 1compartment NA NA Rat Human +DTXSID6052295 Css NA 0.01207 mg/L 3compartmentss NA 50% Rat Human +DTXSID6052295 Css NA 0.1114 mg/L 3compartmentss NA 95% Rat Human +DTXSID6052295 Css NA 0.01276 mg/L PBTK NA 50% Rat Human +DTXSID6052295 Css NA 0.08156 mg/L PBTK NA 95% Rat Human +DTXSID6052326 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052326 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052326 Vd NA 0.5233 L/kg 1compartment NA NA Human Human +DTXSID6052326 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6052326 TK.Half.Life NA 0.9989 hours 1compartment NA NA Human Human +DTXSID6052326 Css NA 0.156 mg/L 3compartmentss NA 50% Human Human +DTXSID6052326 Css NA 1.25 mg/L 3compartmentss NA 95% Human Human +DTXSID6052326 Css NA 0.1015 mg/L PBTK NA 50% Human Human +DTXSID6052326 Css NA 0.7715 mg/L PBTK NA 95% Human Human +DTXSID6052326 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052326 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052326 Vd NA 0.4749 L/kg 1compartment NA NA Rat Human +DTXSID6052326 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6052326 TK.Half.Life NA 0.5112 hours 1compartment NA NA Rat Human +DTXSID6052326 Css NA 0.0204 mg/L 3compartmentss NA 50% Rat Human +DTXSID6052326 Css NA 0.1182 mg/L 3compartmentss NA 95% Rat Human +DTXSID6052326 Css NA 0.01301 mg/L PBTK NA 50% Rat Human +DTXSID6052326 Css NA 0.07135 mg/L PBTK NA 95% Rat Human +DTXSID6052328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052328 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052328 Vd NA 1.321 L/kg 1compartment NA NA Human Human DTXSID6052328 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6052328 TK.Half.Life NA 8.849 hours 1compartment NA NA Human Human -DTXSID6052328 Css NA 0.5986 mg/L 3compartmentss NA 50% Human Human -DTXSID6052328 Css NA 2.907 mg/L 3compartmentss NA 95% Human Human -DTXSID6052328 Css NA 0.4586 mg/L PBTK NA 50% Human Human -DTXSID6052328 Css NA 1.976 mg/L PBTK NA 95% Human Human -DTXSID6052328 Clint NA 2.256 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052328 Fup NA 0.3169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052328 Vd NA 1.251 L/kg 1compartment NA NA Rat Human +DTXSID6052328 TK.Half.Life NA 2.086 hours 1compartment NA NA Human Human +DTXSID6052328 Css NA 0.09982 mg/L 3compartmentss NA 50% Human Human +DTXSID6052328 Css NA 0.6971 mg/L 3compartmentss NA 95% Human Human +DTXSID6052328 Css NA 0.07224 mg/L PBTK NA 50% Human Human +DTXSID6052328 Css NA 0.4721 mg/L PBTK NA 95% Human Human +DTXSID6052328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052328 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052328 Vd NA 1.065 L/kg 1compartment NA NA Rat Human DTXSID6052328 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6052328 TK.Half.Life NA 3.315 hours 1compartment NA NA Rat Human -DTXSID6052328 Css NA 0.2702 mg/L 3compartmentss NA 50% Rat Human -DTXSID6052328 Css NA 1.009 mg/L 3compartmentss NA 95% Rat Human -DTXSID6052328 Css NA 0.2008 mg/L PBTK NA 50% Rat Human -DTXSID6052328 Css NA 0.6358 mg/L PBTK NA 95% Rat Human -DTXSID6052536 Clint NA 16.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052536 Fup NA 0.0711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052536 Vd NA 2.393 L/kg 1compartment NA NA Human Human +DTXSID6052328 TK.Half.Life NA 0.8544 hours 1compartment NA NA Rat Human +DTXSID6052328 Css NA 0.01237 mg/L 3compartmentss NA 50% Rat Human +DTXSID6052328 Css NA 0.06865 mg/L 3compartmentss NA 95% Rat Human +DTXSID6052328 Css NA 0.008928 mg/L PBTK NA 50% Rat Human +DTXSID6052328 Css NA 0.04649 mg/L PBTK NA 95% Rat Human +DTXSID6052536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052536 Fup 0.0713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052536 Vd NA 2.771 L/kg 1compartment NA NA Human Human DTXSID6052536 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6052536 TK.Half.Life NA 16 hours 1compartment NA NA Human Human -DTXSID6052536 Css NA 0.8248 mg/L 3compartmentss NA 50% Human Human -DTXSID6052536 Css NA 5.179 mg/L 3compartmentss NA 95% Human Human -DTXSID6052536 Css NA 0.5584 mg/L PBTK NA 50% Human Human -DTXSID6052536 Css NA 3.357 mg/L PBTK NA 95% Human Human -DTXSID6052536 Clint NA 16.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052536 Fup NA 0.0711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052536 Vd NA 1.798 L/kg 1compartment NA NA Rat Human -DTXSID6052536 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6052536 TK.Half.Life NA 4.324 hours 1compartment NA NA Rat Human -DTXSID6052536 Css NA 0.4564 mg/L 3compartmentss NA 50% Rat Human -DTXSID6052536 Css NA 2.172 mg/L 3compartmentss NA 95% Rat Human -DTXSID6052536 Css NA 0.2942 mg/L PBTK NA 50% Rat Human -DTXSID6052536 Css NA 1.348 mg/L PBTK NA 95% Rat Human -DTXSID6052619 Clint NA 5.617 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052619 Fup NA 0.0697 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6052619 Vd NA 2.189 L/kg 1compartment NA NA Human Human -DTXSID6052619 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID6052619 TK.Half.Life NA 32.59 hours 1compartment NA NA Human Human -DTXSID6052619 Css NA 2.118 mg/L 3compartmentss NA 50% Human Human -DTXSID6052619 Css NA 11.87 mg/L 3compartmentss NA 95% Human Human -DTXSID6052619 Css NA 1.416 mg/L PBTK NA 50% Human Human -DTXSID6052619 Css NA 7.654 mg/L PBTK NA 95% Human Human -DTXSID6052619 Clint NA 5.617 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052619 Fup NA 0.0697 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6052619 Vd NA 1.646 L/kg 1compartment NA NA Rat Human -DTXSID6052619 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6052619 TK.Half.Life NA 9.322 hours 1compartment NA NA Rat Human -DTXSID6052619 Css NA 1.118 mg/L 3compartmentss NA 50% Rat Human -DTXSID6052619 Css NA 4.598 mg/L 3compartmentss NA 95% Rat Human -DTXSID6052619 Css NA 0.7107 mg/L PBTK NA 50% Rat Human -DTXSID6052619 Css NA 2.749 mg/L PBTK NA 95% Rat Human -DTXSID6057611 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057611 Fup NA 0.1466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057611 Vd NA 1.066 L/kg 1compartment NA NA Human Human -DTXSID6057611 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID6057611 TK.Half.Life NA 53.98 hours 1compartment NA NA Human Human -DTXSID6057611 Css NA 6.8 mg/L 3compartmentss NA 50% Human Human -DTXSID6057611 Css NA 30.17 mg/L 3compartmentss NA 95% Human Human -DTXSID6057611 Css NA 4.576 mg/L PBTK NA 50% Human Human -DTXSID6057611 Css NA 18.15 mg/L PBTK NA 95% Human Human -DTXSID6057611 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057611 Fup NA 0.1466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057611 Vd NA 0.8556 L/kg 1compartment NA NA Rat Human -DTXSID6057611 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6057611 TK.Half.Life NA 13.32 hours 1compartment NA NA Rat Human -DTXSID6057611 Css NA 1.922 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057611 Css NA 7.043 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057611 Css NA 1.216 mg/L PBTK NA 50% Rat Human -DTXSID6057611 Css NA 4.002 mg/L PBTK NA 95% Rat Human -DTXSID6057613 Clint NA 135.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057613 Fup NA 0.0266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057613 Vd NA 2.169 L/kg 1compartment NA NA Human Human -DTXSID6057613 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057613 TK.Half.Life NA 4.706 hours 1compartment NA NA Human Human -DTXSID6057613 Css NA 0.2138 mg/L 3compartmentss NA 50% Human Human -DTXSID6057613 Css NA 1.756 mg/L 3compartmentss NA 95% Human Human -DTXSID6057613 Css NA 0.1389 mg/L PBTK NA 50% Human Human -DTXSID6057613 Css NA 1.081 mg/L PBTK NA 95% Human Human -DTXSID6057613 Clint NA 135.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057613 Fup NA 0.0266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057613 Vd NA 1.618 L/kg 1compartment NA NA Rat Human +DTXSID6052536 TK.Half.Life NA 20.57 hours 1compartment NA NA Human Human +DTXSID6052536 Css NA 0.8428 mg/L 3compartmentss NA 50% Human Human +DTXSID6052536 Css NA 5.719 mg/L 3compartmentss NA 95% Human Human +DTXSID6052536 Css NA 0.5805 mg/L PBTK NA 50% Human Human +DTXSID6052536 Css NA 3.727 mg/L PBTK NA 95% Human Human +DTXSID6052536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052536 Fup 0.0713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052536 Vd NA 2.08 L/kg 1compartment NA NA Rat Human +DTXSID6052536 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6052536 TK.Half.Life NA 4.34 hours 1compartment NA NA Rat Human +DTXSID6052536 Css NA 0.1099 mg/L 3compartmentss NA 50% Rat Human +DTXSID6052536 Css NA 0.5853 mg/L 3compartmentss NA 95% Rat Human +DTXSID6052536 Css NA 0.07493 mg/L PBTK NA 50% Rat Human +DTXSID6052536 Css NA 0.3878 mg/L PBTK NA 95% Rat Human +DTXSID6052588 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052588 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052588 Vd NA 1.114 L/kg 1compartment NA NA Human Human +DTXSID6052588 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6052588 TK.Half.Life NA 1.498 hours 1compartment NA NA Human Human +DTXSID6052588 Css NA 0.07214 mg/L 3compartmentss NA 50% Human Human +DTXSID6052588 Css NA 0.5456 mg/L 3compartmentss NA 95% Human Human +DTXSID6052588 Css NA 0.05325 mg/L PBTK NA 50% Human Human +DTXSID6052588 Css NA 0.3707 mg/L PBTK NA 95% Human Human +DTXSID6052588 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052588 Fup 0.29 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052588 Vd NA 0.9368 L/kg 1compartment NA NA Rat Human +DTXSID6052588 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6052588 TK.Half.Life NA 0.6478 hours 1compartment NA NA Rat Human +DTXSID6052588 Css NA 0.008997 mg/L 3compartmentss NA 50% Rat Human +DTXSID6052588 Css NA 0.05097 mg/L 3compartmentss NA 95% Rat Human +DTXSID6052588 Css NA 0.006658 mg/L PBTK NA 50% Rat Human +DTXSID6052588 Css NA 0.03426 mg/L PBTK NA 95% Rat Human +DTXSID6052617 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052617 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052617 Vd NA 0.8802 L/kg 1compartment NA NA Human Human +DTXSID6052617 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6052617 TK.Half.Life NA 12.32 hours 1compartment NA NA Human Human +DTXSID6052617 Css NA 1.427 mg/L 3compartmentss NA 50% Human Human +DTXSID6052617 Css NA 7.084 mg/L 3compartmentss NA 95% Human Human +DTXSID6052617 Css NA 1.148 mg/L PBTK NA 50% Human Human +DTXSID6052617 Css NA 4.652 mg/L PBTK NA 95% Human Human +DTXSID6052617 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052617 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052617 Vd NA 0.8208 L/kg 1compartment NA NA Rat Human +DTXSID6052617 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6052617 TK.Half.Life NA 3.819 hours 1compartment NA NA Rat Human +DTXSID6052617 Css NA 0.08923 mg/L 3compartmentss NA 50% Rat Human +DTXSID6052617 Css NA 0.3956 mg/L 3compartmentss NA 95% Rat Human +DTXSID6052617 Css NA 0.07104 mg/L PBTK NA 50% Rat Human +DTXSID6052617 Css NA 0.2482 mg/L PBTK NA 95% Rat Human +DTXSID6052619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052619 Fup 0.0564 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6052619 Vd NA 1.79 L/kg 1compartment NA NA Human Human +DTXSID6052619 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6052619 TK.Half.Life NA 8.293 hours 1compartment NA NA Human Human +DTXSID6052619 Css NA 0.5931 mg/L 3compartmentss NA 50% Human Human +DTXSID6052619 Css NA 4.305 mg/L 3compartmentss NA 95% Human Human +DTXSID6052619 Css NA 0.3874 mg/L PBTK NA 50% Human Human +DTXSID6052619 Css NA 2.711 mg/L PBTK NA 95% Human Human +DTXSID6052619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052619 Fup 0.0564 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6052619 Vd NA 1.345 L/kg 1compartment NA NA Rat Human +DTXSID6052619 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6052619 TK.Half.Life NA 2.928 hours 1compartment NA NA Rat Human +DTXSID6052619 Css NA 0.07665 mg/L 3compartmentss NA 50% Rat Human +DTXSID6052619 Css NA 0.4467 mg/L 3compartmentss NA 95% Rat Human +DTXSID6052619 Css NA 0.04876 mg/L PBTK NA 50% Rat Human +DTXSID6052619 Css NA 0.2735 mg/L PBTK NA 95% Rat Human +DTXSID60552651 Clint 13.49 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60552651 Fup 0.00678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60552651 Vd NA 2.343 L/kg 1compartment NA NA Human Human +DTXSID60552651 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID60552651 TK.Half.Life NA 74.7 hours 1compartment NA NA Human Human +DTXSID60552651 Css NA 4.8 mg/L 3compartmentss NA 50% Human Human +DTXSID60552651 Css NA 37.57 mg/L 3compartmentss NA 95% Human Human +DTXSID60552651 Css NA 3.109 mg/L PBTK NA 50% Human Human +DTXSID60552651 Css NA 23.65 mg/L PBTK NA 95% Human Human +DTXSID60552651 Clint 13.49 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60552651 Fup 0.00678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60552651 Vd NA 1.741 L/kg 1compartment NA NA Rat Human +DTXSID60552651 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID60552651 TK.Half.Life NA 19.92 hours 1compartment NA NA Rat Human +DTXSID60552651 Css NA 0.6204 mg/L 3compartmentss NA 50% Rat Human +DTXSID60552651 Css NA 3.906 mg/L 3compartmentss NA 95% Rat Human +DTXSID60552651 Css NA 0.3942 mg/L PBTK NA 50% Rat Human +DTXSID60552651 Css NA 2.377 mg/L PBTK NA 95% Rat Human +DTXSID6057611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057611 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057611 Vd NA 0.4557 L/kg 1compartment NA NA Human Human +DTXSID6057611 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6057611 TK.Half.Life NA 0.8081 hours 1compartment NA NA Human Human +DTXSID6057611 Css NA 0.1051 mg/L 3compartmentss NA 50% Human Human +DTXSID6057611 Css NA 0.7806 mg/L 3compartmentss NA 95% Human Human +DTXSID6057611 Css NA 0.0697 mg/L PBTK NA 50% Human Human +DTXSID6057611 Css NA 0.4943 mg/L PBTK NA 95% Human Human +DTXSID6057611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057611 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057611 Vd NA 0.421 L/kg 1compartment NA NA Rat Human +DTXSID6057611 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6057611 TK.Half.Life NA 0.4173 hours 1compartment NA NA Rat Human +DTXSID6057611 Css NA 0.005087 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057611 Css NA 0.03997 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057611 Css NA 0.003327 mg/L PBTK NA 50% Rat Human +DTXSID6057611 Css NA 0.02455 mg/L PBTK NA 95% Rat Human +DTXSID6057613 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057613 Fup 0.0183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057613 Vd NA 1.78 L/kg 1compartment NA NA Human Human +DTXSID6057613 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6057613 TK.Half.Life NA 18.29 hours 1compartment NA NA Human Human +DTXSID6057613 Css NA 1.56 mg/L 3compartmentss NA 50% Human Human +DTXSID6057613 Css NA 14.29 mg/L 3compartmentss NA 95% Human Human +DTXSID6057613 Css NA 0.9876 mg/L PBTK NA 50% Human Human +DTXSID6057613 Css NA 8.684 mg/L PBTK NA 95% Human Human +DTXSID6057613 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057613 Fup 0.0183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057613 Vd NA 1.321 L/kg 1compartment NA NA Rat Human DTXSID6057613 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057613 TK.Half.Life NA 1.464 hours 1compartment NA NA Rat Human -DTXSID6057613 Css NA 0.1196 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057613 Css NA 0.8382 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057613 Css NA 0.07358 mg/L PBTK NA 50% Rat Human -DTXSID6057613 Css NA 0.4888 mg/L PBTK NA 95% Rat Human -DTXSID6057615 Clint NA 12.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057615 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057615 Vd NA 0.2851 L/kg 1compartment NA NA Human Human +DTXSID6057613 TK.Half.Life NA 6.424 hours 1compartment NA NA Rat Human +DTXSID6057613 Css NA 0.2018 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057613 Css NA 1.407 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057613 Css NA 0.1248 mg/L PBTK NA 50% Rat Human +DTXSID6057613 Css NA 0.8359 mg/L PBTK NA 95% Rat Human +DTXSID6057615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057615 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057615 Vd NA 0.4583 L/kg 1compartment NA NA Human Human DTXSID6057615 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057615 TK.Half.Life NA 2.689 hours 1compartment NA NA Human Human -DTXSID6057615 Css NA 1.658 mg/L 3compartmentss NA 50% Human Human -DTXSID6057615 Css NA 12.05 mg/L 3compartmentss NA 95% Human Human -DTXSID6057615 Css NA 0.9988 mg/L PBTK NA 50% Human Human -DTXSID6057615 Css NA 7.308 mg/L PBTK NA 95% Human Human -DTXSID6057615 Clint NA 12.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057615 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057615 Vd NA 0.2785 L/kg 1compartment NA NA Rat Human +DTXSID6057615 TK.Half.Life NA 2.86 hours 1compartment NA NA Human Human +DTXSID6057615 Css NA 0.4601 mg/L 3compartmentss NA 50% Human Human +DTXSID6057615 Css NA 3.503 mg/L 3compartmentss NA 95% Human Human +DTXSID6057615 Css NA 0.3044 mg/L PBTK NA 50% Human Human +DTXSID6057615 Css NA 2.155 mg/L PBTK NA 95% Human Human +DTXSID6057615 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057615 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057615 Vd NA 0.4512 L/kg 1compartment NA NA Rat Human DTXSID6057615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057615 TK.Half.Life NA 1.695 hours 1compartment NA NA Rat Human -DTXSID6057615 Css NA 0.9226 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057615 Css NA 4.945 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057615 Css NA 0.5208 mg/L PBTK NA 50% Rat Human -DTXSID6057615 Css NA 2.706 mg/L PBTK NA 95% Rat Human -DTXSID6057617 Clint NA 16.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057617 Fup NA 0.2902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057617 Vd NA 2.134 L/kg 1compartment NA NA Human Human +DTXSID6057615 TK.Half.Life NA 1.72 hours 1compartment NA NA Rat Human +DTXSID6057615 Css NA 0.004695 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057615 Css NA 0.03035 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057615 Css NA 0.002926 mg/L PBTK NA 50% Rat Human +DTXSID6057615 Css NA 0.01743 mg/L PBTK NA 95% Rat Human +DTXSID6057617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057617 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057617 Vd NA 1.397 L/kg 1compartment NA NA Human Human DTXSID6057617 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057617 TK.Half.Life NA 4.206 hours 1compartment NA NA Human Human -DTXSID6057617 Css NA 0.152 mg/L 3compartmentss NA 50% Human Human -DTXSID6057617 Css NA 0.9343 mg/L 3compartmentss NA 95% Human Human -DTXSID6057617 Css NA 0.1142 mg/L PBTK NA 50% Human Human -DTXSID6057617 Css NA 0.6664 mg/L PBTK NA 95% Human Human -DTXSID6057617 Clint NA 16.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057617 Fup NA 0.2902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057617 Vd NA 1.662 L/kg 1compartment NA NA Rat Human +DTXSID6057617 TK.Half.Life NA 2.85 hours 1compartment NA NA Human Human +DTXSID6057617 Css NA 0.1708 mg/L 3compartmentss NA 50% Human Human +DTXSID6057617 Css NA 1.299 mg/L 3compartmentss NA 95% Human Human +DTXSID6057617 Css NA 0.1177 mg/L PBTK NA 50% Human Human +DTXSID6057617 Css NA 0.8314 mg/L PBTK NA 95% Human Human +DTXSID6057617 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057617 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057617 Vd NA 1.095 L/kg 1compartment NA NA Rat Human DTXSID6057617 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057617 TK.Half.Life NA 1.396 hours 1compartment NA NA Rat Human -DTXSID6057617 Css NA 0.08106 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057617 Css NA 0.3899 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057617 Css NA 0.05925 mg/L PBTK NA 50% Rat Human -DTXSID6057617 Css NA 0.2629 mg/L PBTK NA 95% Rat Human -DTXSID6057619 Clint NA 8.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057619 Fup NA 0.0626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057619 Vd NA 0.3276 L/kg 1compartment NA NA Human Human -DTXSID6057619 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057619 TK.Half.Life NA 2.487 hours 1compartment NA NA Human Human -DTXSID6057619 Css NA 1.224 mg/L 3compartmentss NA 50% Human Human -DTXSID6057619 Css NA 8.253 mg/L 3compartmentss NA 95% Human Human -DTXSID6057619 Css NA 0.7372 mg/L PBTK NA 50% Human Human -DTXSID6057619 Css NA 4.922 mg/L PBTK NA 95% Human Human -DTXSID6057619 Clint NA 8.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057619 Fup NA 0.0626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057619 Vd NA 0.2933 L/kg 1compartment NA NA Rat Human +DTXSID6057617 TK.Half.Life NA 1.139 hours 1compartment NA NA Rat Human +DTXSID6057617 Css NA 0.02205 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057617 Css NA 0.1225 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057617 Css NA 0.01499 mg/L PBTK NA 50% Rat Human +DTXSID6057617 Css NA 0.07621 mg/L PBTK NA 95% Rat Human +DTXSID6057619 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057619 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057619 Vd NA 0.5874 L/kg 1compartment NA NA Human Human +DTXSID6057619 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6057619 TK.Half.Life NA 16.45 hours 1compartment NA NA Human Human +DTXSID6057619 Css NA 2.864 mg/L 3compartmentss NA 50% Human Human +DTXSID6057619 Css NA 10.84 mg/L 3compartmentss NA 95% Human Human +DTXSID6057619 Css NA 1.953 mg/L PBTK NA 50% Human Human +DTXSID6057619 Css NA 6.792 mg/L PBTK NA 95% Human Human +DTXSID6057619 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057619 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057619 Vd NA 0.5229 L/kg 1compartment NA NA Rat Human DTXSID6057619 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057619 TK.Half.Life NA 1.39 hours 1compartment NA NA Rat Human -DTXSID6057619 Css NA 0.6674 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057619 Css NA 3.319 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057619 Css NA 0.3768 mg/L PBTK NA 50% Rat Human -DTXSID6057619 Css NA 1.832 mg/L PBTK NA 95% Rat Human -DTXSID6057661 Clint NA 149.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID6057619 TK.Half.Life NA 4.892 hours 1compartment NA NA Rat Human +DTXSID6057619 Css NA 0.06974 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057619 Css NA 0.3652 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057619 Css NA 0.04658 mg/L PBTK NA 50% Rat Human +DTXSID6057619 Css NA 0.2235 mg/L PBTK NA 95% Rat Human +DTXSID6057661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID6057661 Fup 0.0038 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID6057661 Vd NA 1.667 L/kg 1compartment NA NA Human Human -DTXSID6057661 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057661 TK.Half.Life NA 7.797 hours 1compartment NA NA Human Human -DTXSID6057661 Css NA 0.6566 mg/L 3compartmentss NA 50% Human Human -DTXSID6057661 Css NA 5.017 mg/L 3compartmentss NA 95% Human Human -DTXSID6057661 Css NA 0.4096 mg/L PBTK NA 50% Human Human -DTXSID6057661 Css NA 3.033 mg/L PBTK NA 95% Human Human -DTXSID6057661 Clint NA 149.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID6057661 Vd NA 1.583 L/kg 1compartment NA NA Human Human +DTXSID6057661 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID6057661 TK.Half.Life NA 42.63 hours 1compartment NA NA Human Human +DTXSID6057661 Css NA 4.415 mg/L 3compartmentss NA 50% Human Human +DTXSID6057661 Css NA 36.71 mg/L 3compartmentss NA 95% Human Human +DTXSID6057661 Css NA 2.736 mg/L PBTK NA 50% Human Human +DTXSID6057661 Css NA 22.31 mg/L PBTK NA 95% Human Human +DTXSID6057661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID6057661 Fup 0.0038 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID6057661 Vd NA 1.226 L/kg 1compartment NA NA Rat Human -DTXSID6057661 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057661 TK.Half.Life NA 2.81 hours 1compartment NA NA Rat Human -DTXSID6057661 Css NA 0.3757 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057661 Css NA 2.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057661 Css NA 0.2189 mg/L PBTK NA 50% Rat Human -DTXSID6057661 Css NA 1.331 mg/L PBTK NA 95% Rat Human -DTXSID6057663 Clint NA 1.421 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057663 Fup NA 0.103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057663 Vd NA 0.6648 L/kg 1compartment NA NA Human Human -DTXSID6057663 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID6057663 TK.Half.Life NA 12.85 hours 1compartment NA NA Human Human -DTXSID6057663 Css NA 2.956 mg/L 3compartmentss NA 50% Human Human -DTXSID6057663 Css NA 16.19 mg/L 3compartmentss NA 95% Human Human -DTXSID6057663 Css NA 1.896 mg/L PBTK NA 50% Human Human -DTXSID6057663 Css NA 9.617 mg/L PBTK NA 95% Human Human -DTXSID6057663 Clint NA 1.421 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057663 Fup NA 0.103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057663 Vd NA 0.5518 L/kg 1compartment NA NA Rat Human +DTXSID6057661 Vd NA 1.164 L/kg 1compartment NA NA Rat Human +DTXSID6057661 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID6057661 TK.Half.Life NA 16.02 hours 1compartment NA NA Rat Human +DTXSID6057661 Css NA 0.5934 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057661 Css NA 3.722 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057661 Css NA 0.3565 mg/L PBTK NA 50% Rat Human +DTXSID6057661 Css NA 2.176 mg/L PBTK NA 95% Rat Human +DTXSID6057663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057663 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057663 Vd NA 0.7186 L/kg 1compartment NA NA Human Human +DTXSID6057663 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6057663 TK.Half.Life NA 1.895 hours 1compartment NA NA Human Human +DTXSID6057663 Css NA 0.288 mg/L 3compartmentss NA 50% Human Human +DTXSID6057663 Css NA 2.363 mg/L 3compartmentss NA 95% Human Human +DTXSID6057663 Css NA 0.184 mg/L PBTK NA 50% Human Human +DTXSID6057663 Css NA 1.439 mg/L PBTK NA 95% Human Human +DTXSID6057663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057663 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057663 Vd NA 0.5867 L/kg 1compartment NA NA Rat Human DTXSID6057663 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057663 TK.Half.Life NA 5.475 hours 1compartment NA NA Rat Human -DTXSID6057663 Css NA 1.311 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057663 Css NA 5.569 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057663 Css NA 0.7856 mg/L PBTK NA 50% Rat Human -DTXSID6057663 Css NA 3.103 mg/L PBTK NA 95% Rat Human -DTXSID6057665 Clint NA 39.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057665 Fup NA 0.2756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057665 Vd NA 3.318 L/kg 1compartment NA NA Human Human +DTXSID6057663 TK.Half.Life NA 0.8933 hours 1compartment NA NA Rat Human +DTXSID6057663 Css NA 0.03755 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057663 Css NA 0.2428 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057663 Css NA 0.02331 mg/L PBTK NA 50% Rat Human +DTXSID6057663 Css NA 0.1425 mg/L PBTK NA 95% Rat Human +DTXSID6057665 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057665 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057665 Vd NA 2.9 L/kg 1compartment NA NA Human Human DTXSID6057665 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057665 TK.Half.Life NA 2.44 hours 1compartment NA NA Human Human -DTXSID6057665 Css NA 0.02213 mg/L 3compartmentss NA 50% Human Human -DTXSID6057665 Css NA 0.1981 mg/L 3compartmentss NA 95% Human Human -DTXSID6057665 Css NA 0.02597 mg/L PBTK NA 50% Human Human -DTXSID6057665 Css NA 0.1823 mg/L PBTK NA 95% Human Human -DTXSID6057665 Clint NA 39.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057665 Fup NA 0.2756 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057665 Vd NA 3.349 L/kg 1compartment NA NA Rat Human +DTXSID6057665 TK.Half.Life NA 3.159 hours 1compartment NA NA Human Human +DTXSID6057665 Css NA 0.04698 mg/L 3compartmentss NA 50% Human Human +DTXSID6057665 Css NA 0.3947 mg/L 3compartmentss NA 95% Human Human +DTXSID6057665 Css NA 0.05072 mg/L PBTK NA 50% Human Human +DTXSID6057665 Css NA 0.3545 mg/L PBTK NA 95% Human Human +DTXSID6057665 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057665 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057665 Vd NA 2.918 L/kg 1compartment NA NA Rat Human DTXSID6057665 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057665 TK.Half.Life NA 1.303 hours 1compartment NA NA Rat Human -DTXSID6057665 Css NA 0.0117 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057665 Css NA 0.08427 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057665 Css NA 0.01377 mg/L PBTK NA 50% Rat Human -DTXSID6057665 Css NA 0.07442 mg/L PBTK NA 95% Rat Human -DTXSID6057667 Clint NA 2.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057667 Fup NA 0.376 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057667 Vd NA 1.701 L/kg 1compartment NA NA Human Human +DTXSID6057665 TK.Half.Life NA 1.798 hours 1compartment NA NA Rat Human +DTXSID6057665 Css NA 0.00578 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057665 Css NA 0.03848 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057665 Css NA 0.006414 mg/L PBTK NA 50% Rat Human +DTXSID6057665 Css NA 0.033 mg/L PBTK NA 95% Rat Human +DTXSID6057667 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057667 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057667 Vd NA 1.035 L/kg 1compartment NA NA Human Human DTXSID6057667 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057667 TK.Half.Life NA 9.063 hours 1compartment NA NA Human Human -DTXSID6057667 Css NA 0.536 mg/L 3compartmentss NA 50% Human Human -DTXSID6057667 Css NA 2.652 mg/L 3compartmentss NA 95% Human Human -DTXSID6057667 Css NA 0.425 mg/L PBTK NA 50% Human Human -DTXSID6057667 Css NA 1.817 mg/L PBTK NA 95% Human Human -DTXSID6057667 Clint NA 2.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057667 Fup NA 0.376 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057667 Vd NA 1.377 L/kg 1compartment NA NA Rat Human +DTXSID6057667 TK.Half.Life NA 1.911 hours 1compartment NA NA Human Human +DTXSID6057667 Css NA 0.1308 mg/L 3compartmentss NA 50% Human Human +DTXSID6057667 Css NA 0.9314 mg/L 3compartmentss NA 95% Human Human +DTXSID6057667 Css NA 0.09019 mg/L PBTK NA 50% Human Human +DTXSID6057667 Css NA 0.602 mg/L PBTK NA 95% Human Human +DTXSID6057667 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057667 Fup 0.171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057667 Vd NA 0.8404 L/kg 1compartment NA NA Rat Human DTXSID6057667 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057667 TK.Half.Life NA 3.244 hours 1compartment NA NA Rat Human -DTXSID6057667 Css NA 0.2414 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057667 Css NA 0.922 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057667 Css NA 0.1855 mg/L PBTK NA 50% Rat Human -DTXSID6057667 Css NA 0.5852 mg/L PBTK NA 95% Rat Human +DTXSID6057667 TK.Half.Life NA 0.832 hours 1compartment NA NA Rat Human +DTXSID6057667 Css NA 0.01671 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057667 Css NA 0.08738 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057667 Css NA 0.01145 mg/L PBTK NA 50% Rat Human +DTXSID6057667 Css NA 0.05685 mg/L PBTK NA 95% Rat Human DTXSID6057669 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6057669 Fup NA 0.1992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057669 Vd NA 2.04 L/kg 1compartment NA NA Human Human -DTXSID6057669 Days.Css NA 24 Days PBTK NA NA Human Human -DTXSID6057669 TK.Half.Life NA 123 hours 1compartment NA NA Human Human -DTXSID6057669 Css NA 6.614 mg/L 3compartmentss NA 50% Human Human -DTXSID6057669 Css NA 21.49 mg/L 3compartmentss NA 95% Human Human -DTXSID6057669 Css NA 4.981 mg/L PBTK NA 50% Human Human -DTXSID6057669 Css NA 14.37 mg/L PBTK NA 95% Human Human +DTXSID6057669 Vd NA 2.621 L/kg 1compartment NA NA Human Human +DTXSID6057669 Days.Css NA 68 Days PBTK NA NA Human Human +DTXSID6057669 TK.Half.Life NA 305.2 hours 1compartment NA NA Human Human +DTXSID6057669 Css NA 12.32 mg/L 3compartmentss NA 50% Human Human +DTXSID6057669 Css NA 35.78 mg/L 3compartmentss NA 95% Human Human +DTXSID6057669 Css NA 9.209 mg/L PBTK NA 50% Human Human +DTXSID6057669 Css NA 23.95 mg/L PBTK NA 95% Human Human DTXSID6057669 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6057669 Fup NA 0.1992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057669 Vd NA 1.573 L/kg 1compartment NA NA Rat Human -DTXSID6057669 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID6057669 TK.Half.Life NA 20.97 hours 1compartment NA NA Rat Human -DTXSID6057669 Css NA 1.769 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057669 Css NA 4.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057669 Css NA 1.284 mg/L PBTK NA 50% Rat Human -DTXSID6057669 Css NA 2.949 mg/L PBTK NA 95% Rat Human -DTXSID6057740 Clint NA 52.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057740 Fup NA 0.1889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057740 Vd NA 0.8818 L/kg 1compartment NA NA Human Human +DTXSID6057669 Vd NA 1.994 L/kg 1compartment NA NA Rat Human +DTXSID6057669 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID6057669 TK.Half.Life NA 35.69 hours 1compartment NA NA Rat Human +DTXSID6057669 Css NA 0.7726 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057669 Css NA 1.85 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057669 Css NA 0.5744 mg/L PBTK NA 50% Rat Human +DTXSID6057669 Css NA 1.2 mg/L PBTK NA 95% Rat Human +DTXSID6057740 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057740 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057740 Vd NA 0.6692 L/kg 1compartment NA NA Human Human DTXSID6057740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057740 TK.Half.Life NA 1.044 hours 1compartment NA NA Human Human -DTXSID6057740 Css NA 0.05087 mg/L 3compartmentss NA 50% Human Human -DTXSID6057740 Css NA 0.3664 mg/L 3compartmentss NA 95% Human Human -DTXSID6057740 Css NA 0.03512 mg/L PBTK NA 50% Human Human -DTXSID6057740 Css NA 0.2404 mg/L PBTK NA 95% Human Human -DTXSID6057740 Clint NA 52.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057740 Fup NA 0.1889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057740 Vd NA 0.7386 L/kg 1compartment NA NA Rat Human +DTXSID6057740 TK.Half.Life NA 1.682 hours 1compartment NA NA Human Human +DTXSID6057740 Css NA 0.2168 mg/L 3compartmentss NA 50% Human Human +DTXSID6057740 Css NA 1.387 mg/L 3compartmentss NA 95% Human Human +DTXSID6057740 Css NA 0.1556 mg/L PBTK NA 50% Human Human +DTXSID6057740 Css NA 0.9172 mg/L PBTK NA 95% Human Human +DTXSID6057740 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057740 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057740 Vd NA 0.6242 L/kg 1compartment NA NA Rat Human DTXSID6057740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057740 TK.Half.Life NA 0.439 hours 1compartment NA NA Rat Human -DTXSID6057740 Css NA 0.02833 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057740 Css NA 0.1573 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057740 Css NA 0.01857 mg/L PBTK NA 50% Rat Human -DTXSID6057740 Css NA 0.09829 mg/L PBTK NA 95% Rat Human -DTXSID6057742 Clint NA 1.723 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057742 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057742 Vd NA 0.5546 L/kg 1compartment NA NA Human Human -DTXSID6057742 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6057742 TK.Half.Life NA 16.79 hours 1compartment NA NA Human Human -DTXSID6057742 Css NA 4.9 mg/L 3compartmentss NA 50% Human Human -DTXSID6057742 Css NA 28.14 mg/L 3compartmentss NA 95% Human Human -DTXSID6057742 Css NA 3.104 mg/L PBTK NA 50% Human Human -DTXSID6057742 Css NA 16.66 mg/L PBTK NA 95% Human Human -DTXSID6057742 Clint NA 1.723 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057742 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057742 Vd NA 0.4608 L/kg 1compartment NA NA Rat Human +DTXSID6057740 TK.Half.Life NA 0.8875 hours 1compartment NA NA Rat Human +DTXSID6057740 Css NA 0.02588 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057740 Css NA 0.1201 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057740 Css NA 0.01842 mg/L PBTK NA 50% Rat Human +DTXSID6057740 Css NA 0.07685 mg/L PBTK NA 95% Rat Human +DTXSID6057742 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057742 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057742 Vd NA 0.3342 L/kg 1compartment NA NA Human Human +DTXSID6057742 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6057742 TK.Half.Life NA 9.878 hours 1compartment NA NA Human Human +DTXSID6057742 Css NA 3.539 mg/L 3compartmentss NA 50% Human Human +DTXSID6057742 Css NA 12.73 mg/L 3compartmentss NA 95% Human Human +DTXSID6057742 Css NA 2.329 mg/L PBTK NA 50% Human Human +DTXSID6057742 Css NA 7.734 mg/L PBTK NA 95% Human Human +DTXSID6057742 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057742 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057742 Vd NA 0.3327 L/kg 1compartment NA NA Rat Human DTXSID6057742 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057742 TK.Half.Life NA 7.489 hours 1compartment NA NA Rat Human -DTXSID6057742 Css NA 2.27 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057742 Css NA 10.35 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057742 Css NA 1.341 mg/L PBTK NA 50% Rat Human -DTXSID6057742 Css NA 5.746 mg/L PBTK NA 95% Rat Human -DTXSID6057744 Clint NA 21.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057744 Fup NA 0.0969 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057744 Vd NA 1.83 L/kg 1compartment NA NA Human Human +DTXSID6057742 TK.Half.Life NA 3.35 hours 1compartment NA NA Rat Human +DTXSID6057742 Css NA 0.231 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057742 Css NA 0.6869 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057742 Css NA 0.1478 mg/L PBTK NA 50% Rat Human +DTXSID6057742 Css NA 0.4042 mg/L PBTK NA 95% Rat Human +DTXSID6057744 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057744 Fup 0.0234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057744 Vd NA 1.475 L/kg 1compartment NA NA Human Human DTXSID6057744 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057744 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human -DTXSID6057744 Css NA 0.36 mg/L 3compartmentss NA 50% Human Human -DTXSID6057744 Css NA 2.554 mg/L 3compartmentss NA 95% Human Human -DTXSID6057744 Css NA 0.2408 mg/L PBTK NA 50% Human Human -DTXSID6057744 Css NA 1.636 mg/L PBTK NA 95% Human Human -DTXSID6057744 Clint NA 21.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057744 Fup NA 0.0969 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057744 Vd NA 1.388 L/kg 1compartment NA NA Rat Human +DTXSID6057744 TK.Half.Life NA 12.08 hours 1compartment NA NA Human Human +DTXSID6057744 Css NA 1.229 mg/L 3compartmentss NA 50% Human Human +DTXSID6057744 Css NA 11.45 mg/L 3compartmentss NA 95% Human Human +DTXSID6057744 Css NA 0.7736 mg/L PBTK NA 50% Human Human +DTXSID6057744 Css NA 6.891 mg/L PBTK NA 95% Human Human +DTXSID6057744 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057744 Fup 0.0234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057744 Vd NA 1.095 L/kg 1compartment NA NA Rat Human DTXSID6057744 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057744 TK.Half.Life NA 2.038 hours 1compartment NA NA Rat Human -DTXSID6057744 Css NA 0.2003 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057744 Css NA 1.098 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057744 Css NA 0.1277 mg/L PBTK NA 50% Rat Human -DTXSID6057744 Css NA 0.6575 mg/L PBTK NA 95% Rat Human -DTXSID6057746 Clint NA 55.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057746 Fup NA 0.0168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057746 Vd NA 1.036 L/kg 1compartment NA NA Human Human +DTXSID6057744 TK.Half.Life NA 4.683 hours 1compartment NA NA Rat Human +DTXSID6057744 Css NA 0.1642 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057744 Css NA 1.177 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057744 Css NA 0.09973 mg/L PBTK NA 50% Rat Human +DTXSID6057744 Css NA 0.6817 mg/L PBTK NA 95% Rat Human +DTXSID6057746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057746 Fup 0.0725 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057746 Vd NA 2.27 L/kg 1compartment NA NA Human Human DTXSID6057746 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057746 TK.Half.Life NA 4.699 hours 1compartment NA NA Human Human -DTXSID6057746 Css NA 0.662 mg/L 3compartmentss NA 50% Human Human -DTXSID6057746 Css NA 6.829 mg/L 3compartmentss NA 95% Human Human -DTXSID6057746 Css NA 0.4092 mg/L PBTK NA 50% Human Human -DTXSID6057746 Css NA 4.035 mg/L PBTK NA 95% Human Human -DTXSID6057746 Clint NA 55.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057746 Fup NA 0.0168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057746 Vd NA 0.8302 L/kg 1compartment NA NA Rat Human +DTXSID6057746 TK.Half.Life NA 8.94 hours 1compartment NA NA Human Human +DTXSID6057746 Css NA 0.4456 mg/L 3compartmentss NA 50% Human Human +DTXSID6057746 Css NA 3.216 mg/L 3compartmentss NA 95% Human Human +DTXSID6057746 Css NA 0.315 mg/L PBTK NA 50% Human Human +DTXSID6057746 Css NA 2.122 mg/L PBTK NA 95% Human Human +DTXSID6057746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057746 Fup 0.0725 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057746 Vd NA 1.839 L/kg 1compartment NA NA Rat Human DTXSID6057746 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057746 TK.Half.Life NA 2.237 hours 1compartment NA NA Rat Human -DTXSID6057746 Css NA 0.3771 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057746 Css NA 3.089 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057746 Css NA 0.2189 mg/L PBTK NA 50% Rat Human -DTXSID6057746 Css NA 1.722 mg/L PBTK NA 95% Rat Human -DTXSID6057748 Clint NA 5.669 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057748 Fup NA 0.1394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057748 Vd NA 2.943 L/kg 1compartment NA NA Human Human -DTXSID6057748 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID6057748 TK.Half.Life NA 44.58 hours 1compartment NA NA Human Human -DTXSID6057748 Css NA 1.804 mg/L 3compartmentss NA 50% Human Human -DTXSID6057748 Css NA 9.93 mg/L 3compartmentss NA 95% Human Human -DTXSID6057748 Css NA 1.309 mg/L PBTK NA 50% Human Human -DTXSID6057748 Css NA 6.81 mg/L PBTK NA 95% Human Human -DTXSID6057748 Clint NA 5.669 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057748 Fup NA 0.1394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057748 Vd NA 2.278 L/kg 1compartment NA NA Rat Human -DTXSID6057748 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID6057748 TK.Half.Life NA 9.038 hours 1compartment NA NA Rat Human -DTXSID6057748 Css NA 0.9581 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057748 Css NA 3.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057748 Css NA 0.6659 mg/L PBTK NA 50% Rat Human -DTXSID6057748 Css NA 2.451 mg/L PBTK NA 95% Rat Human +DTXSID6057746 TK.Half.Life NA 3.294 hours 1compartment NA NA Rat Human +DTXSID6057746 Css NA 0.05768 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057746 Css NA 0.3267 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057746 Css NA 0.04024 mg/L PBTK NA 50% Rat Human +DTXSID6057746 Css NA 0.2158 mg/L PBTK NA 95% Rat Human +DTXSID6057748 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057748 Fup 0.0842 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057748 Vd NA 2.839 L/kg 1compartment NA NA Human Human +DTXSID6057748 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6057748 TK.Half.Life NA 17.37 hours 1compartment NA NA Human Human +DTXSID6057748 Css NA 0.6945 mg/L 3compartmentss NA 50% Human Human +DTXSID6057748 Css NA 4.549 mg/L 3compartmentss NA 95% Human Human +DTXSID6057748 Css NA 0.4883 mg/L PBTK NA 50% Human Human +DTXSID6057748 Css NA 3.109 mg/L PBTK NA 95% Human Human +DTXSID6057748 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057748 Fup 0.0842 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057748 Vd NA 2.179 L/kg 1compartment NA NA Rat Human +DTXSID6057748 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6057748 TK.Half.Life NA 3.977 hours 1compartment NA NA Rat Human +DTXSID6057748 Css NA 0.08808 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057748 Css NA 0.4903 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057748 Css NA 0.06142 mg/L PBTK NA 50% Rat Human +DTXSID6057748 Css NA 0.3324 mg/L PBTK NA 95% Rat Human DTXSID6057790 Clint NA 0.001425 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID6057790 Fup NA 0.5504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057790 Vd NA 0.5998 L/kg 1compartment NA NA Human Human +DTXSID6057790 Vd NA 0.5946 L/kg 1compartment NA NA Human Human DTXSID6057790 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057790 TK.Half.Life NA 7.032 hours 1compartment NA NA Human Human -DTXSID6057790 Css NA 1.341 mg/L 3compartmentss NA 50% Human Human -DTXSID6057790 Css NA 8.334 mg/L 3compartmentss NA 95% Human Human -DTXSID6057790 Css NA 1.042 mg/L PBTK NA 50% Human Human -DTXSID6057790 Css NA 5.166 mg/L PBTK NA 95% Human Human +DTXSID6057790 TK.Half.Life NA 6.971 hours 1compartment NA NA Human Human +DTXSID6057790 Css NA 1.134 mg/L 3compartmentss NA 50% Human Human +DTXSID6057790 Css NA 7.137 mg/L 3compartmentss NA 95% Human Human +DTXSID6057790 Css NA 0.884 mg/L PBTK NA 50% Human Human +DTXSID6057790 Css NA 4.496 mg/L PBTK NA 95% Human Human DTXSID6057790 Clint NA 0.001425 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID6057790 Fup NA 0.5504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057790 Vd NA 0.6197 L/kg 1compartment NA NA Rat Human +DTXSID6057790 Vd NA 0.6151 L/kg 1compartment NA NA Rat Human DTXSID6057790 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057790 TK.Half.Life NA 2.48 hours 1compartment NA NA Rat Human -DTXSID6057790 Css NA 0.355 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057790 Css NA 2.164 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057790 Css NA 0.2652 mg/L PBTK NA 50% Rat Human -DTXSID6057790 Css NA 1.263 mg/L PBTK NA 95% Rat Human -DTXSID6057794 Clint NA 13.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057794 Fup NA 0.5773 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057794 Vd NA 0.6537 L/kg 1compartment NA NA Human Human -DTXSID6057794 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057794 TK.Half.Life NA 0.7187 hours 1compartment NA NA Human Human -DTXSID6057794 Css NA 0.06149 mg/L 3compartmentss NA 50% Human Human -DTXSID6057794 Css NA 0.5777 mg/L 3compartmentss NA 95% Human Human -DTXSID6057794 Css NA 0.04784 mg/L PBTK NA 50% Human Human -DTXSID6057794 Css NA 0.3851 mg/L PBTK NA 95% Human Human -DTXSID6057794 Clint NA 13.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057794 Fup NA 0.5773 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057794 Vd NA 0.664 L/kg 1compartment NA NA Rat Human +DTXSID6057790 TK.Half.Life NA 2.461 hours 1compartment NA NA Rat Human +DTXSID6057790 Css NA 0.02148 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057790 Css NA 0.1766 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057790 Css NA 0.01626 mg/L PBTK NA 50% Rat Human +DTXSID6057790 Css NA 0.1112 mg/L PBTK NA 95% Rat Human +DTXSID6057794 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057794 Fup 0.324 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057794 Vd NA 0.5038 L/kg 1compartment NA NA Human Human +DTXSID6057794 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6057794 TK.Half.Life NA 10.09 hours 1compartment NA NA Human Human +DTXSID6057794 Css NA 2.258 mg/L 3compartmentss NA 50% Human Human +DTXSID6057794 Css NA 9.067 mg/L 3compartmentss NA 95% Human Human +DTXSID6057794 Css NA 1.599 mg/L PBTK NA 50% Human Human +DTXSID6057794 Css NA 5.674 mg/L PBTK NA 95% Human Human +DTXSID6057794 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057794 Fup 0.324 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057794 Vd NA 0.5033 L/kg 1compartment NA NA Rat Human DTXSID6057794 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057794 TK.Half.Life NA 0.3779 hours 1compartment NA NA Rat Human -DTXSID6057794 Css NA 0.0313 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057794 Css NA 0.2633 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057794 Css NA 0.02352 mg/L PBTK NA 50% Rat Human -DTXSID6057794 Css NA 0.1623 mg/L PBTK NA 95% Rat Human -DTXSID6057796 Clint NA 0.008145 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057796 Fup NA 0.3299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057796 Vd NA 0.3404 L/kg 1compartment NA NA Human Human +DTXSID6057794 TK.Half.Life NA 3.426 hours 1compartment NA NA Rat Human +DTXSID6057794 Css NA 0.1448 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057794 Css NA 0.4976 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057794 Css NA 0.1008 mg/L PBTK NA 50% Rat Human +DTXSID6057794 Css NA 0.3012 mg/L PBTK NA 95% Rat Human +DTXSID6057796 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057796 Fup 0.609 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057796 Vd NA 0.4583 L/kg 1compartment NA NA Human Human DTXSID6057796 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057796 TK.Half.Life NA 6.589 hours 1compartment NA NA Human Human -DTXSID6057796 Css NA 2.369 mg/L 3compartmentss NA 50% Human Human -DTXSID6057796 Css NA 9.266 mg/L 3compartmentss NA 95% Human Human -DTXSID6057796 Css NA 1.583 mg/L PBTK NA 50% Human Human -DTXSID6057796 Css NA 5.723 mg/L PBTK NA 95% Human Human -DTXSID6057796 Clint NA 0.008145 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057796 Fup NA 0.3299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057796 Vd NA 0.3497 L/kg 1compartment NA NA Rat Human +DTXSID6057796 TK.Half.Life NA 4.871 hours 1compartment NA NA Human Human +DTXSID6057796 Css NA 1.142 mg/L 3compartmentss NA 50% Human Human +DTXSID6057796 Css NA 7.507 mg/L 3compartmentss NA 95% Human Human +DTXSID6057796 Css NA 0.8336 mg/L PBTK NA 50% Human Human +DTXSID6057796 Css NA 4.627 mg/L PBTK NA 95% Human Human +DTXSID6057796 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057796 Fup 0.609 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057796 Vd NA 0.4738 L/kg 1compartment NA NA Rat Human DTXSID6057796 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057796 TK.Half.Life NA 2.322 hours 1compartment NA NA Rat Human -DTXSID6057796 Css NA 0.6634 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057796 Css NA 2.236 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057796 Css NA 0.4178 mg/L PBTK NA 50% Rat Human -DTXSID6057796 Css NA 1.273 mg/L PBTK NA 95% Rat Human -DTXSID6057798 Clint NA 128.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057798 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057798 Vd NA 0.6325 L/kg 1compartment NA NA Human Human +DTXSID6057796 TK.Half.Life NA 1.716 hours 1compartment NA NA Rat Human +DTXSID6057796 Css NA 0.02954 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057796 Css NA 0.2379 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057796 Css NA 0.02099 mg/L PBTK NA 50% Rat Human +DTXSID6057796 Css NA 0.1413 mg/L PBTK NA 95% Rat Human +DTXSID6057798 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057798 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057798 Vd NA 1.736 L/kg 1compartment NA NA Human Human DTXSID6057798 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057798 TK.Half.Life NA 2.115 hours 1compartment NA NA Human Human -DTXSID6057798 Css NA 0.4512 mg/L 3compartmentss NA 50% Human Human -DTXSID6057798 Css NA 4.69 mg/L 3compartmentss NA 95% Human Human -DTXSID6057798 Css NA 0.2684 mg/L PBTK NA 50% Human Human -DTXSID6057798 Css NA 2.758 mg/L PBTK NA 95% Human Human -DTXSID6057798 Clint NA 128.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057798 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057798 Vd NA 0.4845 L/kg 1compartment NA NA Rat Human +DTXSID6057798 TK.Half.Life NA 11.91 hours 1compartment NA NA Human Human +DTXSID6057798 Css NA 0.8788 mg/L 3compartmentss NA 50% Human Human +DTXSID6057798 Css NA 5.651 mg/L 3compartmentss NA 95% Human Human +DTXSID6057798 Css NA 0.6026 mg/L PBTK NA 50% Human Human +DTXSID6057798 Css NA 3.672 mg/L PBTK NA 95% Human Human +DTXSID6057798 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057798 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057798 Vd NA 1.362 L/kg 1compartment NA NA Rat Human DTXSID6057798 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057798 TK.Half.Life NA 0.9734 hours 1compartment NA NA Rat Human -DTXSID6057798 Css NA 0.2638 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057798 Css NA 2.293 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057798 Css NA 0.1468 mg/L PBTK NA 50% Rat Human -DTXSID6057798 Css NA 1.255 mg/L PBTK NA 95% Rat Human -DTXSID6057821 Clint NA 11.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057821 Fup NA 0.0824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057821 Vd NA 2.799 L/kg 1compartment NA NA Human Human -DTXSID6057821 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID6057821 TK.Half.Life NA 35.69 hours 1compartment NA NA Human Human -DTXSID6057821 Css NA 1.603 mg/L 3compartmentss NA 50% Human Human -DTXSID6057821 Css NA 9.855 mg/L 3compartmentss NA 95% Human Human -DTXSID6057821 Css NA 1.108 mg/L PBTK NA 50% Human Human -DTXSID6057821 Css NA 6.504 mg/L PBTK NA 95% Human Human -DTXSID6057821 Clint NA 11.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057821 Fup NA 0.0824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057821 Vd NA 2.102 L/kg 1compartment NA NA Rat Human -DTXSID6057821 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID6057821 TK.Half.Life NA 7.079 hours 1compartment NA NA Rat Human -DTXSID6057821 Css NA 0.884 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057821 Css NA 4.085 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057821 Css NA 0.5831 mg/L PBTK NA 50% Rat Human -DTXSID6057821 Css NA 2.61 mg/L PBTK NA 95% Rat Human -DTXSID6057823 Clint NA 68.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057823 Fup NA 0.0309 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057823 Vd NA 3.1 L/kg 1compartment NA NA Human Human -DTXSID6057823 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID6057823 TK.Half.Life NA 25.75 hours 1compartment NA NA Human Human -DTXSID6057823 Css NA 0.9376 mg/L 3compartmentss NA 50% Human Human -DTXSID6057823 Css NA 6.038 mg/L 3compartmentss NA 95% Human Human -DTXSID6057823 Css NA 0.6502 mg/L PBTK NA 50% Human Human -DTXSID6057823 Css NA 4.07 mg/L PBTK NA 95% Human Human -DTXSID6057823 Clint NA 68.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057823 Fup NA 0.0309 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057823 Vd NA 2.323 L/kg 1compartment NA NA Rat Human -DTXSID6057823 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID6057823 TK.Half.Life NA 3.921 hours 1compartment NA NA Rat Human -DTXSID6057823 Css NA 0.53 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057823 Css NA 2.682 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057823 Css NA 0.3513 mg/L PBTK NA 50% Rat Human -DTXSID6057823 Css NA 1.732 mg/L PBTK NA 95% Rat Human -DTXSID6057825 Clint NA 53.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057825 Fup NA 0.0469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057825 Vd NA 2.415 L/kg 1compartment NA NA Human Human +DTXSID6057798 TK.Half.Life NA 4.501 hours 1compartment NA NA Rat Human +DTXSID6057798 Css NA 0.1066 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057798 Css NA 0.5154 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057798 Css NA 0.07192 mg/L PBTK NA 50% Rat Human +DTXSID6057798 Css NA 0.3168 mg/L PBTK NA 95% Rat Human +DTXSID6057821 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057821 Fup 0.0865 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057821 Vd NA 2.813 L/kg 1compartment NA NA Human Human +DTXSID6057821 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6057821 TK.Half.Life NA 19.62 hours 1compartment NA NA Human Human +DTXSID6057821 Css NA 0.8079 mg/L 3compartmentss NA 50% Human Human +DTXSID6057821 Css NA 5.158 mg/L 3compartmentss NA 95% Human Human +DTXSID6057821 Css NA 0.5596 mg/L PBTK NA 50% Human Human +DTXSID6057821 Css NA 3.428 mg/L PBTK NA 95% Human Human +DTXSID6057821 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057821 Fup 0.0865 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057821 Vd NA 2.115 L/kg 1compartment NA NA Rat Human +DTXSID6057821 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6057821 TK.Half.Life NA 4.037 hours 1compartment NA NA Rat Human +DTXSID6057821 Css NA 0.1026 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057821 Css NA 0.5688 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057821 Css NA 0.07018 mg/L PBTK NA 50% Rat Human +DTXSID6057821 Css NA 0.3819 mg/L PBTK NA 95% Rat Human +DTXSID6057823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057823 Fup 0.0114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057823 Vd NA 3.096 L/kg 1compartment NA NA Human Human +DTXSID6057823 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID6057823 TK.Half.Life NA 89.68 hours 1compartment NA NA Human Human +DTXSID6057823 Css NA 3.452 mg/L 3compartmentss NA 50% Human Human +DTXSID6057823 Css NA 22.18 mg/L 3compartmentss NA 95% Human Human +DTXSID6057823 Css NA 2.396 mg/L PBTK NA 50% Human Human +DTXSID6057823 Css NA 15.02 mg/L PBTK NA 95% Human Human +DTXSID6057823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057823 Fup 0.0114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057823 Vd NA 2.32 L/kg 1compartment NA NA Rat Human +DTXSID6057823 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID6057823 TK.Half.Life NA 12.42 hours 1compartment NA NA Rat Human +DTXSID6057823 Css NA 0.4493 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057823 Css NA 2.374 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057823 Css NA 0.307 mg/L PBTK NA 50% Rat Human +DTXSID6057823 Css NA 1.612 mg/L PBTK NA 95% Rat Human +DTXSID6057825 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057825 Fup 0.0382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057825 Vd NA 2.208 L/kg 1compartment NA NA Human Human DTXSID6057825 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057825 TK.Half.Life NA 4.407 hours 1compartment NA NA Human Human -DTXSID6057825 Css NA 0.1596 mg/L 3compartmentss NA 50% Human Human -DTXSID6057825 Css NA 1.275 mg/L 3compartmentss NA 95% Human Human -DTXSID6057825 Css NA 0.1167 mg/L PBTK NA 50% Human Human -DTXSID6057825 Css NA 0.8517 mg/L PBTK NA 95% Human Human -DTXSID6057825 Clint NA 53.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057825 Fup NA 0.0469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057825 Vd NA 2.056 L/kg 1compartment NA NA Rat Human +DTXSID6057825 TK.Half.Life NA 8.391 hours 1compartment NA NA Human Human +DTXSID6057825 Css NA 0.4654 mg/L 3compartmentss NA 50% Human Human +DTXSID6057825 Css NA 4.197 mg/L 3compartmentss NA 95% Human Human +DTXSID6057825 Css NA 0.3284 mg/L PBTK NA 50% Human Human +DTXSID6057825 Css NA 2.735 mg/L PBTK NA 95% Human Human +DTXSID6057825 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057825 Fup 0.0382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057825 Vd NA 1.873 L/kg 1compartment NA NA Rat Human DTXSID6057825 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057825 TK.Half.Life NA 1.784 hours 1compartment NA NA Rat Human -DTXSID6057825 Css NA 0.08824 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057825 Css NA 0.5791 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057825 Css NA 0.0617 mg/L PBTK NA 50% Rat Human -DTXSID6057825 Css NA 0.372 mg/L PBTK NA 95% Rat Human -DTXSID6057827 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057827 Fup NA 0.7369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057827 Vd NA 0.4881 L/kg 1compartment NA NA Human Human +DTXSID6057825 TK.Half.Life NA 3.599 hours 1compartment NA NA Rat Human +DTXSID6057825 Css NA 0.05968 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057825 Css NA 0.4367 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057825 Css NA 0.04162 mg/L PBTK NA 50% Rat Human +DTXSID6057825 Css NA 0.2787 mg/L PBTK NA 95% Rat Human +DTXSID6057827 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057827 Fup 0.685 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057827 Vd NA 0.472 L/kg 1compartment NA NA Human Human DTXSID6057827 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057827 TK.Half.Life NA 4.287 hours 1compartment NA NA Human Human -DTXSID6057827 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID6057827 Css NA 6.885 mg/L 3compartmentss NA 95% Human Human -DTXSID6057827 Css NA 0.8475 mg/L PBTK NA 50% Human Human -DTXSID6057827 Css NA 4.269 mg/L PBTK NA 95% Human Human -DTXSID6057827 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057827 Fup NA 0.7369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057827 Vd NA 0.5095 L/kg 1compartment NA NA Rat Human +DTXSID6057827 TK.Half.Life NA 4.458 hours 1compartment NA NA Human Human +DTXSID6057827 Css NA 0.6622 mg/L 3compartmentss NA 50% Human Human +DTXSID6057827 Css NA 4.335 mg/L 3compartmentss NA 95% Human Human +DTXSID6057827 Css NA 0.4883 mg/L PBTK NA 50% Human Human +DTXSID6057827 Css NA 2.683 mg/L PBTK NA 95% Human Human +DTXSID6057827 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057827 Fup 0.685 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057827 Vd NA 0.4919 L/kg 1compartment NA NA Rat Human DTXSID6057827 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057827 TK.Half.Life NA 1.524 hours 1compartment NA NA Rat Human -DTXSID6057827 Css NA 0.3022 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057827 Css NA 1.762 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057827 Css NA 0.2146 mg/L PBTK NA 50% Rat Human -DTXSID6057827 Css NA 1.015 mg/L PBTK NA 95% Rat Human -DTXSID6057829 Clint NA 32.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057829 Fup NA 0.3636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID6057829 Vd NA 0.733 L/kg 1compartment NA NA Human Human +DTXSID6057827 TK.Half.Life NA 1.584 hours 1compartment NA NA Rat Human +DTXSID6057827 Css NA 0.003485 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057827 Css NA 0.02223 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057827 Css NA 0.002464 mg/L PBTK NA 50% Rat Human +DTXSID6057827 Css NA 0.01327 mg/L PBTK NA 95% Rat Human +DTXSID6057829 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057829 Fup 0.309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057829 Vd NA 0.6702 L/kg 1compartment NA NA Human Human DTXSID6057829 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID6057829 TK.Half.Life NA 0.766 hours 1compartment NA NA Human Human -DTXSID6057829 Css NA 0.04005 mg/L 3compartmentss NA 50% Human Human -DTXSID6057829 Css NA 0.2963 mg/L 3compartmentss NA 95% Human Human -DTXSID6057829 Css NA 0.02914 mg/L PBTK NA 50% Human Human -DTXSID6057829 Css NA 0.1958 mg/L PBTK NA 95% Human Human -DTXSID6057829 Clint NA 32.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057829 Fup NA 0.3636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID6057829 Vd NA 0.6586 L/kg 1compartment NA NA Rat Human +DTXSID6057829 TK.Half.Life NA 0.8739 hours 1compartment NA NA Human Human +DTXSID6057829 Css NA 0.0669 mg/L 3compartmentss NA 50% Human Human +DTXSID6057829 Css NA 0.4967 mg/L 3compartmentss NA 95% Human Human +DTXSID6057829 Css NA 0.04716 mg/L PBTK NA 50% Human Human +DTXSID6057829 Css NA 0.3296 mg/L PBTK NA 95% Human Human +DTXSID6057829 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057829 Fup 0.309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057829 Vd NA 0.6014 L/kg 1compartment NA NA Rat Human DTXSID6057829 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID6057829 TK.Half.Life NA 0.3421 hours 1compartment NA NA Rat Human -DTXSID6057829 Css NA 0.02139 mg/L 3compartmentss NA 50% Rat Human -DTXSID6057829 Css NA 0.1335 mg/L 3compartmentss NA 95% Rat Human -DTXSID6057829 Css NA 0.015 mg/L PBTK NA 50% Rat Human -DTXSID6057829 Css NA 0.08381 mg/L PBTK NA 95% Rat Human +DTXSID6057829 TK.Half.Life NA 0.4106 hours 1compartment NA NA Rat Human +DTXSID6057829 Css NA 0.008387 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057829 Css NA 0.04851 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057829 Css NA 0.005912 mg/L PBTK NA 50% Rat Human +DTXSID6057829 Css NA 0.03127 mg/L PBTK NA 95% Rat Human +DTXSID6057875 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057875 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057875 Vd NA 1.791 L/kg 1compartment NA NA Human Human +DTXSID6057875 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID6057875 TK.Half.Life NA 25.4 hours 1compartment NA NA Human Human +DTXSID6057875 Css NA 1.935 mg/L 3compartmentss NA 50% Human Human +DTXSID6057875 Css NA 10.57 mg/L 3compartmentss NA 95% Human Human +DTXSID6057875 Css NA 1.304 mg/L PBTK NA 50% Human Human +DTXSID6057875 Css NA 6.725 mg/L PBTK NA 95% Human Human +DTXSID6057875 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057875 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057875 Vd NA 1.367 L/kg 1compartment NA NA Rat Human +DTXSID6057875 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6057875 TK.Half.Life NA 8.377 hours 1compartment NA NA Rat Human +DTXSID6057875 Css NA 0.2225 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057875 Css NA 0.8752 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057875 Css NA 0.1474 mg/L PBTK NA 50% Rat Human +DTXSID6057875 Css NA 0.5315 mg/L PBTK NA 95% Rat Human +DTXSID6057900 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057900 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6057900 Vd NA 1.284 L/kg 1compartment NA NA Human Human +DTXSID6057900 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6057900 TK.Half.Life NA 3.616 hours 1compartment NA NA Human Human +DTXSID6057900 Css NA 0.2416 mg/L 3compartmentss NA 50% Human Human +DTXSID6057900 Css NA 1.528 mg/L 3compartmentss NA 95% Human Human +DTXSID6057900 Css NA 0.1858 mg/L PBTK NA 50% Human Human +DTXSID6057900 Css NA 1.041 mg/L PBTK NA 95% Human Human +DTXSID6057900 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057900 Fup 0.264 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6057900 Vd NA 1.188 L/kg 1compartment NA NA Rat Human +DTXSID6057900 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6057900 TK.Half.Life NA 1.879 hours 1compartment NA NA Rat Human +DTXSID6057900 Css NA 0.0283 mg/L 3compartmentss NA 50% Rat Human +DTXSID6057900 Css NA 0.1333 mg/L 3compartmentss NA 95% Rat Human +DTXSID6057900 Css NA 0.0219 mg/L PBTK NA 50% Rat Human +DTXSID6057900 Css NA 0.08955 mg/L PBTK NA 95% Rat Human +DTXSID6058631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6058631 Fup 0.0472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6058631 Vd NA 2.943 L/kg 1compartment NA NA Human Human +DTXSID6058631 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID6058631 TK.Half.Life NA 30.97 hours 1compartment NA NA Human Human +DTXSID6058631 Css NA 1.268 mg/L 3compartmentss NA 50% Human Human +DTXSID6058631 Css NA 8.235 mg/L 3compartmentss NA 95% Human Human +DTXSID6058631 Css NA 0.8834 mg/L PBTK NA 50% Human Human +DTXSID6058631 Css NA 5.579 mg/L PBTK NA 95% Human Human +DTXSID6058631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6058631 Fup 0.0472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6058631 Vd NA 2.241 L/kg 1compartment NA NA Rat Human +DTXSID6058631 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID6058631 TK.Half.Life NA 6.091 hours 1compartment NA NA Rat Human +DTXSID6058631 Css NA 0.1638 mg/L 3compartmentss NA 50% Rat Human +DTXSID6058631 Css NA 0.89 mg/L 3compartmentss NA 95% Rat Human +DTXSID6058631 Css NA 0.113 mg/L PBTK NA 50% Rat Human +DTXSID6058631 Css NA 0.5886 mg/L PBTK NA 95% Rat Human +DTXSID6058689 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6058689 Fup 0.666 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6058689 Vd NA 0.4343 L/kg 1compartment NA NA Human Human +DTXSID6058689 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6058689 TK.Half.Life NA 4.219 hours 1compartment NA NA Human Human +DTXSID6058689 Css NA 1.215 mg/L 3compartmentss NA 50% Human Human +DTXSID6058689 Css NA 7.42 mg/L 3compartmentss NA 95% Human Human +DTXSID6058689 Css NA 0.8844 mg/L PBTK NA 50% Human Human +DTXSID6058689 Css NA 4.594 mg/L PBTK NA 95% Human Human +DTXSID6058689 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6058689 Fup 0.666 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6058689 Vd NA 0.4501 L/kg 1compartment NA NA Rat Human +DTXSID6058689 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6058689 TK.Half.Life NA 1.49 hours 1compartment NA NA Rat Human +DTXSID6058689 Css NA 0.07381 mg/L 3compartmentss NA 50% Rat Human +DTXSID6058689 Css NA 0.4217 mg/L 3compartmentss NA 95% Rat Human +DTXSID6058689 Css NA 0.05326 mg/L PBTK NA 50% Rat Human +DTXSID6058689 Css NA 0.2504 mg/L PBTK NA 95% Rat Human +DTXSID6060632 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6060632 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6060632 Vd NA 1.398 L/kg 1compartment NA NA Human Human +DTXSID6060632 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6060632 TK.Half.Life NA 13.69 hours 1compartment NA NA Human Human +DTXSID6060632 Css NA 1.547 mg/L 3compartmentss NA 50% Human Human +DTXSID6060632 Css NA 14.03 mg/L 3compartmentss NA 95% Human Human +DTXSID6060632 Css NA 0.9634 mg/L PBTK NA 50% Human Human +DTXSID6060632 Css NA 8.462 mg/L PBTK NA 95% Human Human +DTXSID6060632 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6060632 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6060632 Vd NA 1.036 L/kg 1compartment NA NA Rat Human +DTXSID6060632 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6060632 TK.Half.Life NA 5.432 hours 1compartment NA NA Rat Human +DTXSID6060632 Css NA 0.1996 mg/L 3compartmentss NA 50% Rat Human +DTXSID6060632 Css NA 1.485 mg/L 3compartmentss NA 95% Rat Human +DTXSID6060632 Css NA 0.1204 mg/L PBTK NA 50% Rat Human +DTXSID6060632 Css NA 0.8514 mg/L PBTK NA 95% Rat Human +DTXSID6060769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6060769 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6060769 Vd NA 0.4998 L/kg 1compartment NA NA Human Human +DTXSID6060769 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID6060769 TK.Half.Life NA 0.8395 hours 1compartment NA NA Human Human +DTXSID6060769 Css NA 0.109 mg/L 3compartmentss NA 50% Human Human +DTXSID6060769 Css NA 0.809 mg/L 3compartmentss NA 95% Human Human +DTXSID6060769 Css NA 0.07307 mg/L PBTK NA 50% Human Human +DTXSID6060769 Css NA 0.5084 mg/L PBTK NA 95% Human Human +DTXSID6060769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6060769 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6060769 Vd NA 0.4706 L/kg 1compartment NA NA Rat Human +DTXSID6060769 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID6060769 TK.Half.Life NA 0.437 hours 1compartment NA NA Rat Human +DTXSID6060769 Css NA 0.01411 mg/L 3compartmentss NA 50% Rat Human +DTXSID6060769 Css NA 0.07737 mg/L 3compartmentss NA 95% Rat Human +DTXSID6060769 Css NA 0.009296 mg/L PBTK NA 50% Rat Human +DTXSID6060769 Css NA 0.0485 mg/L PBTK NA 95% Rat Human +DTXSID6063143 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6063143 Fup 0.00733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6063143 Vd NA 3.089 L/kg 1compartment NA NA Human Human +DTXSID6063143 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID6063143 TK.Half.Life NA 92.49 hours 1compartment NA NA Human Human +DTXSID6063143 Css NA 3.538 mg/L 3compartmentss NA 50% Human Human +DTXSID6063143 Css NA 21.67 mg/L 3compartmentss NA 95% Human Human +DTXSID6063143 Css NA 2.438 mg/L PBTK NA 50% Human Human +DTXSID6063143 Css NA 14.65 mg/L PBTK NA 95% Human Human +DTXSID6063143 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6063143 Fup 0.00733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6063143 Vd NA 2.313 L/kg 1compartment NA NA Rat Human +DTXSID6063143 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID6063143 TK.Half.Life NA 12.94 hours 1compartment NA NA Rat Human +DTXSID6063143 Css NA 0.4675 mg/L 3compartmentss NA 50% Rat Human +DTXSID6063143 Css NA 2.36 mg/L 3compartmentss NA 95% Rat Human +DTXSID6063143 Css NA 0.3186 mg/L PBTK NA 50% Rat Human +DTXSID6063143 Css NA 1.609 mg/L PBTK NA 95% Rat Human +DTXSID6063351 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6063351 Fup 0.0296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID6063351 Vd NA 2.26 L/kg 1compartment NA NA Human Human +DTXSID6063351 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID6063351 TK.Half.Life NA 19.64 hours 1compartment NA NA Human Human +DTXSID6063351 Css NA 1.209 mg/L 3compartmentss NA 50% Human Human +DTXSID6063351 Css NA 9.613 mg/L 3compartmentss NA 95% Human Human +DTXSID6063351 Css NA 0.7957 mg/L PBTK NA 50% Human Human +DTXSID6063351 Css NA 6.02 mg/L PBTK NA 95% Human Human +DTXSID6063351 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6063351 Fup 0.0296 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID6063351 Vd NA 1.687 L/kg 1compartment NA NA Rat Human +DTXSID6063351 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID6063351 TK.Half.Life NA 5.626 hours 1compartment NA NA Rat Human +DTXSID6063351 Css NA 0.1557 mg/L 3compartmentss NA 50% Rat Human +DTXSID6063351 Css NA 0.9603 mg/L 3compartmentss NA 95% Rat Human +DTXSID6063351 Css NA 0.1004 mg/L PBTK NA 50% Rat Human +DTXSID6063351 Css NA 0.5958 mg/L PBTK NA 95% Rat Human +DTXSID60838720 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60838720 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60838720 Vd NA 3.011 L/kg 1compartment NA NA Human Human +DTXSID60838720 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60838720 TK.Half.Life NA 3.349 hours 1compartment NA NA Human Human +DTXSID60838720 Css NA 0.06242 mg/L 3compartmentss NA 50% Human Human +DTXSID60838720 Css NA 0.6032 mg/L 3compartmentss NA 95% Human Human +DTXSID60838720 Css NA 0.05583 mg/L PBTK NA 50% Human Human +DTXSID60838720 Css NA 0.4599 mg/L PBTK NA 95% Human Human +DTXSID60838720 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60838720 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60838720 Vd NA 2.844 L/kg 1compartment NA NA Rat Human +DTXSID60838720 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60838720 TK.Half.Life NA 1.616 hours 1compartment NA NA Rat Human +DTXSID60838720 Css NA 0.00777 mg/L 3compartmentss NA 50% Rat Human +DTXSID60838720 Css NA 0.06287 mg/L 3compartmentss NA 95% Rat Human +DTXSID60838720 Css NA 0.007048 mg/L PBTK NA 50% Rat Human +DTXSID60838720 Css NA 0.049 mg/L PBTK NA 95% Rat Human +DTXSID60860001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60860001 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60860001 Vd NA 3.839 L/kg 1compartment NA NA Human Human +DTXSID60860001 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60860001 TK.Half.Life NA 4.153 hours 1compartment NA NA Human Human +DTXSID60860001 Css NA 0.04632 mg/L 3compartmentss NA 50% Human Human +DTXSID60860001 Css NA 0.3536 mg/L 3compartmentss NA 95% Human Human +DTXSID60860001 Css NA 0.04026 mg/L PBTK NA 50% Human Human +DTXSID60860001 Css NA 0.2788 mg/L PBTK NA 95% Human Human +DTXSID60860001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60860001 Fup 0.08 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60860001 Vd NA 3.27 L/kg 1compartment NA NA Rat Human +DTXSID60860001 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60860001 TK.Half.Life NA 1.307 hours 1compartment NA NA Rat Human +DTXSID60860001 Css NA 0.005992 mg/L 3compartmentss NA 50% Rat Human +DTXSID60860001 Css NA 0.03747 mg/L 3compartmentss NA 95% Rat Human +DTXSID60860001 Css NA 0.005327 mg/L PBTK NA 50% Rat Human +DTXSID60860001 Css NA 0.03027 mg/L PBTK NA 95% Rat Human +DTXSID60860142 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60860142 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60860142 Vd NA 2.235 L/kg 1compartment NA NA Human Human +DTXSID60860142 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60860142 TK.Half.Life NA 3.494 hours 1compartment NA NA Human Human +DTXSID60860142 Css NA 0.07106 mg/L 3compartmentss NA 50% Human Human +DTXSID60860142 Css NA 0.5478 mg/L 3compartmentss NA 95% Human Human +DTXSID60860142 Css NA 0.1243 mg/L PBTK NA 50% Human Human +DTXSID60860142 Css NA 0.9585 mg/L PBTK NA 95% Human Human +DTXSID60860142 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60860142 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60860142 Vd NA 2.105 L/kg 1compartment NA NA Rat Human +DTXSID60860142 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60860142 TK.Half.Life NA 1.904 hours 1compartment NA NA Rat Human +DTXSID60860142 Css NA 0.008719 mg/L 3compartmentss NA 50% Rat Human +DTXSID60860142 Css NA 0.0517 mg/L 3compartmentss NA 95% Rat Human +DTXSID60860142 Css NA 0.0158 mg/L PBTK NA 50% Rat Human +DTXSID60860142 Css NA 0.09344 mg/L PBTK NA 95% Rat Human +DTXSID60860420 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60860420 Fup 0.0205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60860420 Vd NA 58.7 L/kg 1compartment NA NA Human Human +DTXSID60860420 Days.Css NA 440 Days PBTK NA NA Human Human +DTXSID60860420 TK.Half.Life NA 1726 hours 1compartment NA NA Human Human +DTXSID60860420 Css NA 0.357 mg/L 3compartmentss NA 50% Human Human +DTXSID60860420 Css NA 2.213 mg/L 3compartmentss NA 95% Human Human +DTXSID60860420 Css NA 2.38 mg/L PBTK NA 50% Human Human +DTXSID60860420 Css NA 13.61 mg/L PBTK NA 95% Human Human +DTXSID60860420 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60860420 Fup 0.0205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60860420 Vd NA 49.78 L/kg 1compartment NA NA Rat Human +DTXSID60860420 Days.Css NA 272 Days PBTK NA NA Rat Human +DTXSID60860420 TK.Half.Life NA 251.1 hours 1compartment NA NA Rat Human +DTXSID60860420 Css NA 0.04241 mg/L 3compartmentss NA 50% Rat Human +DTXSID60860420 Css NA 0.2015 mg/L 3compartmentss NA 95% Rat Human +DTXSID60860420 Css NA 0.3093 mg/L PBTK NA 50% Rat Human +DTXSID60860420 Css NA 1.548 mg/L PBTK NA 95% Rat Human +DTXSID60861376 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60861376 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60861376 Vd NA 1.972 L/kg 1compartment NA NA Human Human +DTXSID60861376 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60861376 TK.Half.Life NA 4.44 hours 1compartment NA NA Human Human +DTXSID60861376 Css NA 0.1424 mg/L 3compartmentss NA 50% Human Human +DTXSID60861376 Css NA 1.002 mg/L 3compartmentss NA 95% Human Human +DTXSID60861376 Css NA 0.1273 mg/L PBTK NA 50% Human Human +DTXSID60861376 Css NA 0.7596 mg/L PBTK NA 95% Human Human +DTXSID60861376 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60861376 Fup 0.342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60861376 Vd NA 1.896 L/kg 1compartment NA NA Rat Human +DTXSID60861376 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60861376 TK.Half.Life NA 2.358 hours 1compartment NA NA Rat Human +DTXSID60861376 Css NA 0.006032 mg/L 3compartmentss NA 50% Rat Human +DTXSID60861376 Css NA 0.05236 mg/L 3compartmentss NA 95% Rat Human +DTXSID60861376 Css NA 0.005498 mg/L PBTK NA 50% Rat Human +DTXSID60861376 Css NA 0.03869 mg/L PBTK NA 95% Rat Human +DTXSID60863012 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60863012 Fup 0.0247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60863012 Vd NA 3.126 L/kg 1compartment NA NA Human Human +DTXSID60863012 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID60863012 TK.Half.Life NA 93.64 hours 1compartment NA NA Human Human +DTXSID60863012 Css NA 3.401 mg/L 3compartmentss NA 50% Human Human +DTXSID60863012 Css NA 20.77 mg/L 3compartmentss NA 95% Human Human +DTXSID60863012 Css NA 2.351 mg/L PBTK NA 50% Human Human +DTXSID60863012 Css NA 14.27 mg/L PBTK NA 95% Human Human +DTXSID60863012 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60863012 Fup 0.0247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60863012 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID60863012 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID60863012 TK.Half.Life NA 12.47 hours 1compartment NA NA Rat Human +DTXSID60863012 Css NA 0.4516 mg/L 3compartmentss NA 50% Rat Human +DTXSID60863012 Css NA 2.13 mg/L 3compartmentss NA 95% Rat Human +DTXSID60863012 Css NA 0.3096 mg/L PBTK NA 50% Rat Human +DTXSID60863012 Css NA 1.473 mg/L PBTK NA 95% Rat Human +DTXSID60869332 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60869332 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60869332 Vd NA 2.974 L/kg 1compartment NA NA Human Human +DTXSID60869332 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60869332 TK.Half.Life NA 14 hours 1compartment NA NA Human Human +DTXSID60869332 Css NA 0.4611 mg/L 3compartmentss NA 50% Human Human +DTXSID60869332 Css NA 2.883 mg/L 3compartmentss NA 95% Human Human +DTXSID60869332 Css NA 0.3323 mg/L PBTK NA 50% Human Human +DTXSID60869332 Css NA 1.976 mg/L PBTK NA 95% Human Human +DTXSID60869332 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60869332 Fup 0.237 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60869332 Vd NA 2.253 L/kg 1compartment NA NA Rat Human +DTXSID60869332 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60869332 TK.Half.Life NA 2.766 hours 1compartment NA NA Rat Human +DTXSID60869332 Css NA 0.05878 mg/L 3compartmentss NA 50% Rat Human +DTXSID60869332 Css NA 0.2925 mg/L 3compartmentss NA 95% Rat Human +DTXSID60869332 Css NA 0.04216 mg/L PBTK NA 50% Rat Human +DTXSID60869332 Css NA 0.2021 mg/L PBTK NA 95% Rat Human +DTXSID60869418 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60869418 Fup 0.014 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60869418 Vd NA 2.305 L/kg 1compartment NA NA Human Human +DTXSID60869418 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID60869418 TK.Half.Life NA 17.46 hours 1compartment NA NA Human Human +DTXSID60869418 Css NA 0.8654 mg/L 3compartmentss NA 50% Human Human +DTXSID60869418 Css NA 6.698 mg/L 3compartmentss NA 95% Human Human +DTXSID60869418 Css NA 0.7096 mg/L PBTK NA 50% Human Human +DTXSID60869418 Css NA 5.492 mg/L PBTK NA 95% Human Human DTXSID60869418 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID60869418 Fup 0.02 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID60869418 Vd NA 1.978 L/kg 1compartment NA NA Rat Rat -DTXSID60869418 Days.Css NA 154 Days PBTK NA NA Rat Rat -DTXSID60869418 TK.Half.Life NA 306 hours 1compartment NA NA Rat Rat -DTXSID60869418 Css NA 33.25 mg/L 3compartmentss NA 50% Rat Rat -DTXSID60869418 Css NA 111.6 mg/L 3compartmentss NA 95% Rat Rat -DTXSID60869418 Css NA 20.84 mg/L PBTK NA 50% Rat Rat -DTXSID60869418 Css NA 63.41 mg/L PBTK NA 95% Rat Rat +DTXSID60869418 Vd NA 1.971 L/kg 1compartment NA NA Rat Rat +DTXSID60869418 Days.Css NA 151 Days PBTK NA NA Rat Rat +DTXSID60869418 TK.Half.Life NA 303.1 hours 1compartment NA NA Rat Rat +DTXSID60869418 Css NA 5.624 mg/L 3compartmentss NA 50% Rat Rat +DTXSID60869418 Css NA 17.45 mg/L 3compartmentss NA 95% Rat Rat +DTXSID60869418 Css NA 4.776 mg/L PBTK NA 50% Rat Rat +DTXSID60869418 Css NA 14.82 mg/L PBTK NA 95% Rat Rat +DTXSID60870165 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60870165 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60870165 Vd NA 2.779 L/kg 1compartment NA NA Human Human +DTXSID60870165 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60870165 TK.Half.Life NA 5.307 hours 1compartment NA NA Human Human +DTXSID60870165 Css NA 0.1327 mg/L 3compartmentss NA 50% Human Human +DTXSID60870165 Css NA 1.188 mg/L 3compartmentss NA 95% Human Human +DTXSID60870165 Css NA 0.1142 mg/L PBTK NA 50% Human Human +DTXSID60870165 Css NA 0.873 mg/L PBTK NA 95% Human Human +DTXSID60870165 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60870165 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60870165 Vd NA 2.616 L/kg 1compartment NA NA Rat Human +DTXSID60870165 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60870165 TK.Half.Life NA 2.668 hours 1compartment NA NA Rat Human +DTXSID60870165 Css NA 0.006287 mg/L 3compartmentss NA 50% Rat Human +DTXSID60870165 Css NA 0.06708 mg/L 3compartmentss NA 95% Rat Human +DTXSID60870165 Css NA 0.005416 mg/L PBTK NA 50% Rat Human +DTXSID60870165 Css NA 0.04749 mg/L PBTK NA 95% Rat Human +DTXSID60871172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60871172 Fup 0.0396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60871172 Vd NA 3.061 L/kg 1compartment NA NA Human Human +DTXSID60871172 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID60871172 TK.Half.Life NA 58.1 hours 1compartment NA NA Human Human +DTXSID60871172 Css NA 2.276 mg/L 3compartmentss NA 50% Human Human +DTXSID60871172 Css NA 15.18 mg/L 3compartmentss NA 95% Human Human +DTXSID60871172 Css NA 1.564 mg/L PBTK NA 50% Human Human +DTXSID60871172 Css NA 10.14 mg/L PBTK NA 95% Human Human +DTXSID60871172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60871172 Fup 0.0396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60871172 Vd NA 2.293 L/kg 1compartment NA NA Rat Human +DTXSID60871172 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID60871172 TK.Half.Life NA 8.629 hours 1compartment NA NA Rat Human +DTXSID60871172 Css NA 0.2953 mg/L 3compartmentss NA 50% Rat Human +DTXSID60871172 Css NA 1.736 mg/L 3compartmentss NA 95% Rat Human +DTXSID60871172 Css NA 0.2024 mg/L PBTK NA 50% Rat Human +DTXSID60871172 Css NA 1.143 mg/L PBTK NA 95% Rat Human +DTXSID60872346 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60872346 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60872346 Vd NA 1.046 L/kg 1compartment NA NA Human Human +DTXSID60872346 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60872346 TK.Half.Life NA 1.146 hours 1compartment NA NA Human Human +DTXSID60872346 Css NA 0.04806 mg/L 3compartmentss NA 50% Human Human +DTXSID60872346 Css NA 0.3864 mg/L 3compartmentss NA 95% Human Human +DTXSID60872346 Css NA 0.03825 mg/L PBTK NA 50% Human Human +DTXSID60872346 Css NA 0.2748 mg/L PBTK NA 95% Human Human +DTXSID60872346 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60872346 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60872346 Vd NA 1.053 L/kg 1compartment NA NA Rat Human +DTXSID60872346 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60872346 TK.Half.Life NA 0.6054 hours 1compartment NA NA Rat Human +DTXSID60872346 Css NA 0.005902 mg/L 3compartmentss NA 50% Rat Human +DTXSID60872346 Css NA 0.03761 mg/L 3compartmentss NA 95% Rat Human +DTXSID60872346 Css NA 0.004737 mg/L PBTK NA 50% Rat Human +DTXSID60872346 Css NA 0.02683 mg/L PBTK NA 95% Rat Human +DTXSID60873338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60873338 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60873338 Vd NA 0.5462 L/kg 1compartment NA NA Human Human +DTXSID60873338 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60873338 TK.Half.Life NA 0.5219 hours 1compartment NA NA Human Human +DTXSID60873338 Css NA 0.01417 mg/L 3compartmentss NA 50% Human Human +DTXSID60873338 Css NA 0.2089 mg/L 3compartmentss NA 95% Human Human +DTXSID60873338 Css NA 0.0108 mg/L PBTK NA 50% Human Human +DTXSID60873338 Css NA 0.1373 mg/L PBTK NA 95% Human Human +DTXSID60873338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60873338 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60873338 Vd NA 0.559 L/kg 1compartment NA NA Rat Human +DTXSID60873338 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60873338 TK.Half.Life NA 0.2658 hours 1compartment NA NA Rat Human +DTXSID60873338 Css NA 0.0001204 mg/L 3compartmentss NA 50% Rat Human +DTXSID60873338 Css NA 0.001826 mg/L 3compartmentss NA 95% Rat Human +DTXSID60873338 Css NA 8.874e-05 mg/L PBTK NA 50% Rat Human +DTXSID60873338 Css NA 0.001133 mg/L PBTK NA 95% Rat Human +DTXSID60873378 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60873378 Fup 0.35 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60873378 Vd NA 0.3067 L/kg 1compartment NA NA Human Human +DTXSID60873378 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60873378 TK.Half.Life NA 5.668 hours 1compartment NA NA Human Human +DTXSID60873378 Css NA 1.226 mg/L 3compartmentss NA 50% Human Human +DTXSID60873378 Css NA 5.115 mg/L 3compartmentss NA 95% Human Human +DTXSID60873378 Css NA 0.815 mg/L PBTK NA 50% Human Human +DTXSID60873378 Css NA 3.143 mg/L PBTK NA 95% Human Human +DTXSID60873378 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60873378 Fup 0.35 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60873378 Vd NA 0.3183 L/kg 1compartment NA NA Rat Human +DTXSID60873378 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60873378 TK.Half.Life NA 2.006 hours 1compartment NA NA Rat Human +DTXSID60873378 Css NA 0.006603 mg/L 3compartmentss NA 50% Rat Human +DTXSID60873378 Css NA 0.02849 mg/L 3compartmentss NA 95% Rat Human +DTXSID60873378 Css NA 0.004162 mg/L PBTK NA 50% Rat Human +DTXSID60873378 Css NA 0.01651 mg/L PBTK NA 95% Rat Human +DTXSID60880663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880663 Fup 0.0177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880663 Vd NA 3.035 L/kg 1compartment NA NA Human Human +DTXSID60880663 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID60880663 TK.Half.Life NA 68.7 hours 1compartment NA NA Human Human +DTXSID60880663 Css NA 2.797 mg/L 3compartmentss NA 50% Human Human +DTXSID60880663 Css NA 18.29 mg/L 3compartmentss NA 95% Human Human +DTXSID60880663 Css NA 1.924 mg/L PBTK NA 50% Human Human +DTXSID60880663 Css NA 12.08 mg/L PBTK NA 95% Human Human +DTXSID60880663 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880663 Fup 0.0177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880663 Vd NA 2.273 L/kg 1compartment NA NA Rat Human +DTXSID60880663 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID60880663 TK.Half.Life NA 10.43 hours 1compartment NA NA Rat Human +DTXSID60880663 Css NA 0.3599 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880663 Css NA 2.075 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880663 Css NA 0.2451 mg/L PBTK NA 50% Rat Human +DTXSID60880663 Css NA 1.376 mg/L PBTK NA 95% Rat Human +DTXSID60880668 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880668 Fup 0.45 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880668 Vd NA 0.823 L/kg 1compartment NA NA Human Human +DTXSID60880668 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60880668 TK.Half.Life NA 0.859 hours 1compartment NA NA Human Human +DTXSID60880668 Css NA 0.042 mg/L 3compartmentss NA 50% Human Human +DTXSID60880668 Css NA 0.3732 mg/L 3compartmentss NA 95% Human Human +DTXSID60880668 Css NA 0.03304 mg/L PBTK NA 50% Human Human +DTXSID60880668 Css NA 0.2598 mg/L PBTK NA 95% Human Human +DTXSID60880668 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880668 Fup 0.45 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880668 Vd NA 0.7722 L/kg 1compartment NA NA Rat Human +DTXSID60880668 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60880668 TK.Half.Life NA 0.4089 hours 1compartment NA NA Rat Human +DTXSID60880668 Css NA 0.005278 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880668 Css NA 0.03514 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880668 Css NA 0.004099 mg/L PBTK NA 50% Rat Human +DTXSID60880668 Css NA 0.02385 mg/L PBTK NA 95% Rat Human +DTXSID60880688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880688 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880688 Vd NA 2.778 L/kg 1compartment NA NA Human Human +DTXSID60880688 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID60880688 TK.Half.Life NA 48.64 hours 1compartment NA NA Human Human +DTXSID60880688 Css NA 2.312 mg/L 3compartmentss NA 50% Human Human +DTXSID60880688 Css NA 16.33 mg/L 3compartmentss NA 95% Human Human +DTXSID60880688 Css NA 1.557 mg/L PBTK NA 50% Human Human +DTXSID60880688 Css NA 10.55 mg/L PBTK NA 95% Human Human +DTXSID60880688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880688 Fup 0.0145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880688 Vd NA 2.077 L/kg 1compartment NA NA Rat Human +DTXSID60880688 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID60880688 TK.Half.Life NA 9.662 hours 1compartment NA NA Rat Human +DTXSID60880688 Css NA 0.3005 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880688 Css NA 1.789 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880688 Css NA 0.1994 mg/L PBTK NA 50% Rat Human +DTXSID60880688 Css NA 1.142 mg/L PBTK NA 95% Rat Human +DTXSID60880724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880724 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880724 Vd NA 47.03 L/kg 1compartment NA NA Human Human +DTXSID60880724 Days.Css NA 346 Days PBTK NA NA Human Human +DTXSID60880724 TK.Half.Life NA 1383 hours 1compartment NA NA Human Human +DTXSID60880724 Css NA 0.4563 mg/L 3compartmentss NA 50% Human Human +DTXSID60880724 Css NA 2.915 mg/L 3compartmentss NA 95% Human Human +DTXSID60880724 Css NA 2.344 mg/L PBTK NA 50% Human Human +DTXSID60880724 Css NA 14.04 mg/L PBTK NA 95% Human Human +DTXSID60880724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880724 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880724 Vd NA 39.55 L/kg 1compartment NA NA Rat Human +DTXSID60880724 Days.Css NA 214 Days PBTK NA NA Rat Human +DTXSID60880724 TK.Half.Life NA 199.1 hours 1compartment NA NA Rat Human +DTXSID60880724 Css NA 0.05422 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880724 Css NA 0.2603 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880724 Css NA 0.3066 mg/L PBTK NA 50% Rat Human +DTXSID60880724 Css NA 1.509 mg/L PBTK NA 95% Rat Human +DTXSID60880769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880769 Fup 0.0798 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880769 Vd NA 2.153 L/kg 1compartment NA NA Human Human +DTXSID60880769 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60880769 TK.Half.Life NA 8.968 hours 1compartment NA NA Human Human +DTXSID60880769 Css NA 0.4857 mg/L 3compartmentss NA 50% Human Human +DTXSID60880769 Css NA 3.338 mg/L 3compartmentss NA 95% Human Human +DTXSID60880769 Css NA 0.3262 mg/L PBTK NA 50% Human Human +DTXSID60880769 Css NA 2.168 mg/L PBTK NA 95% Human Human +DTXSID60880769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880769 Fup 0.0798 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880769 Vd NA 1.623 L/kg 1compartment NA NA Rat Human +DTXSID60880769 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60880769 TK.Half.Life NA 2.78 hours 1compartment NA NA Rat Human +DTXSID60880769 Css NA 0.06294 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880769 Css NA 0.338 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880769 Css NA 0.04174 mg/L PBTK NA 50% Rat Human +DTXSID60880769 Css NA 0.2148 mg/L PBTK NA 95% Rat Human +DTXSID60880820 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880820 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880820 Vd NA 2.037 L/kg 1compartment NA NA Human Human +DTXSID60880820 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60880820 TK.Half.Life NA 2.937 hours 1compartment NA NA Human Human +DTXSID60880820 Css NA 0.08366 mg/L 3compartmentss NA 50% Human Human +DTXSID60880820 Css NA 0.584 mg/L 3compartmentss NA 95% Human Human +DTXSID60880820 Css NA 0.06525 mg/L PBTK NA 50% Human Human +DTXSID60880820 Css NA 0.4237 mg/L PBTK NA 95% Human Human +DTXSID60880820 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880820 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880820 Vd NA 1.605 L/kg 1compartment NA NA Rat Human +DTXSID60880820 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60880820 TK.Half.Life NA 1.022 hours 1compartment NA NA Rat Human +DTXSID60880820 Css NA 0.01045 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880820 Css NA 0.05727 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880820 Css NA 0.00813 mg/L PBTK NA 50% Rat Human +DTXSID60880820 Css NA 0.04165 mg/L PBTK NA 95% Rat Human +DTXSID60880840 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880840 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880840 Vd NA 4.201 L/kg 1compartment NA NA Human Human +DTXSID60880840 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID60880840 TK.Half.Life NA 126.1 hours 1compartment NA NA Human Human +DTXSID60880840 Css NA 1.699 mg/L 3compartmentss NA 50% Human Human +DTXSID60880840 Css NA 10.58 mg/L 3compartmentss NA 95% Human Human +DTXSID60880840 Css NA 1.291 mg/L PBTK NA 50% Human Human +DTXSID60880840 Css NA 7.895 mg/L PBTK NA 95% Human Human +DTXSID60880840 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880840 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880840 Vd NA 3.184 L/kg 1compartment NA NA Rat Human +DTXSID60880840 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID60880840 TK.Half.Life NA 16.84 hours 1compartment NA NA Rat Human +DTXSID60880840 Css NA 0.01832 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880840 Css NA 0.1075 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880840 Css NA 0.01347 mg/L PBTK NA 50% Rat Human +DTXSID60880840 Css NA 0.0778 mg/L PBTK NA 95% Rat Human +DTXSID60880880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880880 Fup 0.0224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880880 Vd NA 3.123 L/kg 1compartment NA NA Human Human +DTXSID60880880 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID60880880 TK.Half.Life NA 92.63 hours 1compartment NA NA Human Human +DTXSID60880880 Css NA 1.879 mg/L 3compartmentss NA 50% Human Human +DTXSID60880880 Css NA 12.05 mg/L 3compartmentss NA 95% Human Human +DTXSID60880880 Css NA 1.311 mg/L PBTK NA 50% Human Human +DTXSID60880880 Css NA 8.191 mg/L PBTK NA 95% Human Human +DTXSID60880880 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880880 Fup 0.0224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880880 Vd NA 2.34 L/kg 1compartment NA NA Rat Human +DTXSID60880880 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID60880880 TK.Half.Life NA 12.39 hours 1compartment NA NA Rat Human +DTXSID60880880 Css NA 0.02056 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880880 Css NA 0.1285 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880880 Css NA 0.01368 mg/L PBTK NA 50% Rat Human +DTXSID60880880 Css NA 0.08515 mg/L PBTK NA 95% Rat Human +DTXSID60880885 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880885 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880885 Vd NA 1.048 L/kg 1compartment NA NA Human Human +DTXSID60880885 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60880885 TK.Half.Life NA 3.344 hours 1compartment NA NA Human Human +DTXSID60880885 Css NA 0.298 mg/L 3compartmentss NA 50% Human Human +DTXSID60880885 Css NA 1.792 mg/L 3compartmentss NA 95% Human Human +DTXSID60880885 Css NA 0.2167 mg/L PBTK NA 50% Human Human +DTXSID60880885 Css NA 1.183 mg/L PBTK NA 95% Human Human +DTXSID60880885 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880885 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880885 Vd NA 0.9188 L/kg 1compartment NA NA Rat Human +DTXSID60880885 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60880885 TK.Half.Life NA 1.642 hours 1compartment NA NA Rat Human +DTXSID60880885 Css NA 0.03478 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880885 Css NA 0.1565 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880885 Css NA 0.025 mg/L PBTK NA 50% Rat Human +DTXSID60880885 Css NA 0.1019 mg/L PBTK NA 95% Rat Human +DTXSID60880901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880901 Fup 0.0256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880901 Vd NA 35.46 L/kg 1compartment NA NA Human Human +DTXSID60880901 Days.Css NA 63 Days PBTK NA NA Human Human +DTXSID60880901 TK.Half.Life NA 311.8 hours 1compartment NA NA Human Human +DTXSID60880901 Css NA 0.1396 mg/L 3compartmentss NA 50% Human Human +DTXSID60880901 Css NA 1.973 mg/L 3compartmentss NA 95% Human Human +DTXSID60880901 Css NA 0.4768 mg/L PBTK NA 50% Human Human +DTXSID60880901 Css NA 3.85 mg/L PBTK NA 95% Human Human +DTXSID60880901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880901 Fup 0.0256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880901 Vd NA 29.52 L/kg 1compartment NA NA Rat Human +DTXSID60880901 Days.Css NA 41 Days PBTK NA NA Rat Human +DTXSID60880901 TK.Half.Life NA 99.09 hours 1compartment NA NA Rat Human +DTXSID60880901 Css NA 0.001344 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880901 Css NA 0.01679 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880901 Css NA 0.004924 mg/L PBTK NA 50% Rat Human +DTXSID60880901 Css NA 0.0345 mg/L PBTK NA 95% Rat Human +DTXSID60880921 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880921 Fup 0.0435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60880921 Vd NA 1.759 L/kg 1compartment NA NA Human Human +DTXSID60880921 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60880921 TK.Half.Life NA 9.746 hours 1compartment NA NA Human Human +DTXSID60880921 Css NA 0.747 mg/L 3compartmentss NA 50% Human Human +DTXSID60880921 Css NA 6.307 mg/L 3compartmentss NA 95% Human Human +DTXSID60880921 Css NA 0.4808 mg/L PBTK NA 50% Human Human +DTXSID60880921 Css NA 3.891 mg/L PBTK NA 95% Human Human +DTXSID60880921 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880921 Fup 0.0435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60880921 Vd NA 1.317 L/kg 1compartment NA NA Rat Human +DTXSID60880921 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60880921 TK.Half.Life NA 3.469 hours 1compartment NA NA Rat Human +DTXSID60880921 Css NA 0.09679 mg/L 3compartmentss NA 50% Rat Human +DTXSID60880921 Css NA 0.6189 mg/L 3compartmentss NA 95% Rat Human +DTXSID60880921 Css NA 0.06122 mg/L PBTK NA 50% Rat Human +DTXSID60880921 Css NA 0.3688 mg/L PBTK NA 95% Rat Human +DTXSID60893450 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60893450 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID60893450 Vd NA 1.056 L/kg 1compartment NA NA Human Human +DTXSID60893450 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60893450 TK.Half.Life NA 6.836 hours 1compartment NA NA Human Human +DTXSID60893450 Css NA 0.9859 mg/L 3compartmentss NA 50% Human Human +DTXSID60893450 Css NA 8.951 mg/L 3compartmentss NA 95% Human Human +DTXSID60893450 Css NA 0.6108 mg/L PBTK NA 50% Human Human +DTXSID60893450 Css NA 5.421 mg/L PBTK NA 95% Human Human +DTXSID60893450 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60893450 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID60893450 Vd NA 0.789 L/kg 1compartment NA NA Rat Human +DTXSID60893450 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60893450 TK.Half.Life NA 2.938 hours 1compartment NA NA Rat Human +DTXSID60893450 Css NA 0.1292 mg/L 3compartmentss NA 50% Rat Human +DTXSID60893450 Css NA 0.9542 mg/L 3compartmentss NA 95% Rat Human +DTXSID60893450 Css NA 0.07755 mg/L PBTK NA 50% Rat Human +DTXSID60893450 Css NA 0.5481 mg/L PBTK NA 95% Rat Human +DTXSID60927527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60927527 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60927527 Vd NA 1.293 L/kg 1compartment NA NA Human Human +DTXSID60927527 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60927527 TK.Half.Life NA 2.907 hours 1compartment NA NA Human Human +DTXSID60927527 Css NA 0.2083 mg/L 3compartmentss NA 50% Human Human +DTXSID60927527 Css NA 1.634 mg/L 3compartmentss NA 95% Human Human +DTXSID60927527 Css NA 0.1396 mg/L PBTK NA 50% Human Human +DTXSID60927527 Css NA 1.036 mg/L PBTK NA 95% Human Human +DTXSID60927527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60927527 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60927527 Vd NA 1.011 L/kg 1compartment NA NA Rat Human +DTXSID60927527 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60927527 TK.Half.Life NA 1.188 hours 1compartment NA NA Rat Human +DTXSID60927527 Css NA 0.02568 mg/L 3compartmentss NA 50% Rat Human +DTXSID60927527 Css NA 0.1597 mg/L 3compartmentss NA 95% Rat Human +DTXSID60927527 Css NA 0.017 mg/L PBTK NA 50% Rat Human +DTXSID60927527 Css NA 0.099 mg/L PBTK NA 95% Rat Human +DTXSID60998873 Clint 21.38 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60998873 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID60998873 Vd NA 0.819 L/kg 1compartment NA NA Human Human +DTXSID60998873 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID60998873 TK.Half.Life NA 1.214 hours 1compartment NA NA Human Human +DTXSID60998873 Css NA 0.08784 mg/L 3compartmentss NA 50% Human Human +DTXSID60998873 Css NA 0.6316 mg/L 3compartmentss NA 95% Human Human +DTXSID60998873 Css NA 0.06179 mg/L PBTK NA 50% Human Human +DTXSID60998873 Css NA 0.4124 mg/L PBTK NA 95% Human Human +DTXSID60998873 Clint 21.38 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60998873 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID60998873 Vd NA 0.7123 L/kg 1compartment NA NA Rat Human +DTXSID60998873 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID60998873 TK.Half.Life NA 0.564 hours 1compartment NA NA Rat Human +DTXSID60998873 Css NA 0.01108 mg/L 3compartmentss NA 50% Rat Human +DTXSID60998873 Css NA 0.06004 mg/L 3compartmentss NA 95% Rat Human +DTXSID60998873 Css NA 0.007764 mg/L PBTK NA 50% Rat Human +DTXSID60998873 Css NA 0.03945 mg/L PBTK NA 95% Rat Human +DTXSID701007266 Clint 5.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID701007266 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID701007266 Vd NA 2.212 L/kg 1compartment NA NA Human Human +DTXSID701007266 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID701007266 TK.Half.Life NA 15.87 hours 1compartment NA NA Human Human +DTXSID701007266 Css NA 0.7767 mg/L 3compartmentss NA 50% Human Human +DTXSID701007266 Css NA 4.153 mg/L 3compartmentss NA 95% Human Human +DTXSID701007266 Css NA 0.5544 mg/L PBTK NA 50% Human Human +DTXSID701007266 Css NA 2.847 mg/L PBTK NA 95% Human Human +DTXSID701007266 Clint 5.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID701007266 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID701007266 Vd NA 1.691 L/kg 1compartment NA NA Rat Human +DTXSID701007266 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID701007266 TK.Half.Life NA 4.64 hours 1compartment NA NA Rat Human +DTXSID701007266 Css NA 0.09154 mg/L 3compartmentss NA 50% Rat Human +DTXSID701007266 Css NA 0.3444 mg/L 3compartmentss NA 95% Rat Human +DTXSID701007266 Css NA 0.06528 mg/L PBTK NA 50% Rat Human +DTXSID701007266 Css NA 0.229 mg/L PBTK NA 95% Rat Human +DTXSID701009329 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID701009329 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID701009329 Vd NA 2.555 L/kg 1compartment NA NA Human Human +DTXSID701009329 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID701009329 TK.Half.Life NA 10.24 hours 1compartment NA NA Human Human +DTXSID701009329 Css NA 0.4091 mg/L 3compartmentss NA 50% Human Human +DTXSID701009329 Css NA 3.501 mg/L 3compartmentss NA 95% Human Human +DTXSID701009329 Css NA 0.3598 mg/L PBTK NA 50% Human Human +DTXSID701009329 Css NA 2.599 mg/L PBTK NA 95% Human Human +DTXSID701009329 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID701009329 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID701009329 Vd NA 2.528 L/kg 1compartment NA NA Rat Human +DTXSID701009329 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID701009329 TK.Half.Life NA 6.205 hours 1compartment NA NA Rat Human +DTXSID701009329 Css NA 0.05028 mg/L 3compartmentss NA 50% Rat Human +DTXSID701009329 Css NA 0.3475 mg/L 3compartmentss NA 95% Rat Human +DTXSID701009329 Css NA 0.04438 mg/L PBTK NA 50% Rat Human +DTXSID701009329 Css NA 0.2424 mg/L PBTK NA 95% Rat Human +DTXSID701105307 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID701105307 Fup 0.0946 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID701105307 Vd NA 3.066 L/kg 1compartment NA NA Human Human +DTXSID701105307 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID701105307 TK.Half.Life NA 41.09 hours 1compartment NA NA Human Human +DTXSID701105307 Css NA 1.268 mg/L 3compartmentss NA 50% Human Human +DTXSID701105307 Css NA 8.601 mg/L 3compartmentss NA 95% Human Human +DTXSID701105307 Css NA 0.8858 mg/L PBTK NA 50% Human Human +DTXSID701105307 Css NA 5.759 mg/L PBTK NA 95% Human Human +DTXSID701105307 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID701105307 Fup 0.0946 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID701105307 Vd NA 2.3 L/kg 1compartment NA NA Rat Human +DTXSID701105307 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID701105307 TK.Half.Life NA 6.239 hours 1compartment NA NA Rat Human +DTXSID701105307 Css NA 0.03605 mg/L 3compartmentss NA 50% Rat Human +DTXSID701105307 Css NA 0.2998 mg/L 3compartmentss NA 95% Rat Human +DTXSID701105307 Css NA 0.02411 mg/L PBTK NA 50% Rat Human +DTXSID701105307 Css NA 0.1968 mg/L PBTK NA 95% Rat Human +DTXSID701108218 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID701108218 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID701108218 Vd NA 1.636 L/kg 1compartment NA NA Human Human +DTXSID701108218 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID701108218 TK.Half.Life NA 4.324 hours 1compartment NA NA Human Human +DTXSID701108218 Css NA 0.2355 mg/L 3compartmentss NA 50% Human Human +DTXSID701108218 Css NA 1.779 mg/L 3compartmentss NA 95% Human Human +DTXSID701108218 Css NA 0.1596 mg/L PBTK NA 50% Human Human +DTXSID701108218 Css NA 1.143 mg/L PBTK NA 95% Human Human +DTXSID701108218 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID701108218 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID701108218 Vd NA 1.251 L/kg 1compartment NA NA Rat Human +DTXSID701108218 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID701108218 TK.Half.Life NA 1.612 hours 1compartment NA NA Rat Human +DTXSID701108218 Css NA 0.01054 mg/L 3compartmentss NA 50% Rat Human +DTXSID701108218 Css NA 0.08506 mg/L 3compartmentss NA 95% Rat Human +DTXSID701108218 Css NA 0.006904 mg/L PBTK NA 50% Rat Human +DTXSID701108218 Css NA 0.05207 mg/L PBTK NA 95% Rat Human +DTXSID701188254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID701188254 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID701188254 Vd NA 3.114 L/kg 1compartment NA NA Human Human +DTXSID701188254 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID701188254 TK.Half.Life NA 4.007 hours 1compartment NA NA Human Human +DTXSID701188254 Css NA 0.0659 mg/L 3compartmentss NA 50% Human Human +DTXSID701188254 Css NA 0.5025 mg/L 3compartmentss NA 95% Human Human +DTXSID701188254 Css NA 0.06296 mg/L PBTK NA 50% Human Human +DTXSID701188254 Css NA 0.4258 mg/L PBTK NA 95% Human Human +DTXSID701188254 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID701188254 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID701188254 Vd NA 2.896 L/kg 1compartment NA NA Rat Human +DTXSID701188254 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID701188254 TK.Half.Life NA 1.813 hours 1compartment NA NA Rat Human +DTXSID701188254 Css NA 0.007984 mg/L 3compartmentss NA 50% Rat Human +DTXSID701188254 Css NA 0.04728 mg/L 3compartmentss NA 95% Rat Human +DTXSID701188254 Css NA 0.007952 mg/L PBTK NA 50% Rat Human +DTXSID701188254 Css NA 0.0394 mg/L PBTK NA 95% Rat Human +DTXSID70147214 Clint 25.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70147214 Fup 0.0827 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70147214 Vd NA 0.3715 L/kg 1compartment NA NA Human Human +DTXSID70147214 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70147214 TK.Half.Life NA 0.9981 hours 1compartment NA NA Human Human +DTXSID70147214 Css NA 0.2681 mg/L 3compartmentss NA 50% Human Human +DTXSID70147214 Css NA 2.175 mg/L 3compartmentss NA 95% Human Human +DTXSID70147214 Css NA 0.1646 mg/L PBTK NA 50% Human Human +DTXSID70147214 Css NA 1.306 mg/L PBTK NA 95% Human Human +DTXSID70147214 Clint 25.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70147214 Fup 0.0827 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70147214 Vd NA 0.3387 L/kg 1compartment NA NA Rat Human +DTXSID70147214 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70147214 TK.Half.Life NA 0.5419 hours 1compartment NA NA Rat Human +DTXSID70147214 Css NA 0.01328 mg/L 3compartmentss NA 50% Rat Human +DTXSID70147214 Css NA 0.1147 mg/L 3compartmentss NA 95% Rat Human +DTXSID70147214 Css NA 0.007859 mg/L PBTK NA 50% Rat Human +DTXSID70147214 Css NA 0.06586 mg/L PBTK NA 95% Rat Human +DTXSID70152666 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70152666 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70152666 Vd NA 6.641 L/kg 1compartment NA NA Human Human +DTXSID70152666 Days.Css NA 36 Days PBTK NA NA Human Human +DTXSID70152666 TK.Half.Life NA 191 hours 1compartment NA NA Human Human +DTXSID70152666 Css NA 2.582 mg/L 3compartmentss NA 50% Human Human +DTXSID70152666 Css NA 16.3 mg/L 3compartmentss NA 95% Human Human +DTXSID70152666 Css NA 2.403 mg/L PBTK NA 50% Human Human +DTXSID70152666 Css NA 14.24 mg/L PBTK NA 95% Human Human +DTXSID70152666 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70152666 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70152666 Vd NA 5.136 L/kg 1compartment NA NA Rat Human +DTXSID70152666 Days.Css NA 21 Days PBTK NA NA Rat Human +DTXSID70152666 TK.Half.Life NA 26.45 hours 1compartment NA NA Rat Human +DTXSID70152666 Css NA 0.3252 mg/L 3compartmentss NA 50% Rat Human +DTXSID70152666 Css NA 1.719 mg/L 3compartmentss NA 95% Rat Human +DTXSID70152666 Css NA 0.3057 mg/L PBTK NA 50% Rat Human +DTXSID70152666 Css NA 1.542 mg/L PBTK NA 95% Rat Human +DTXSID70153355 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70153355 Fup 0.0736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70153355 Vd NA 2.152 L/kg 1compartment NA NA Human Human +DTXSID70153355 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID70153355 TK.Half.Life NA 27.31 hours 1compartment NA NA Human Human +DTXSID70153355 Css NA 1.644 mg/L 3compartmentss NA 50% Human Human +DTXSID70153355 Css NA 9.666 mg/L 3compartmentss NA 95% Human Human +DTXSID70153355 Css NA 1.099 mg/L PBTK NA 50% Human Human +DTXSID70153355 Css NA 6.193 mg/L PBTK NA 95% Human Human +DTXSID70153355 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70153355 Fup 0.0736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70153355 Vd NA 1.619 L/kg 1compartment NA NA Rat Human +DTXSID70153355 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID70153355 TK.Half.Life NA 8.022 hours 1compartment NA NA Rat Human +DTXSID70153355 Css NA 0.1337 mg/L 3compartmentss NA 50% Rat Human +DTXSID70153355 Css NA 0.6901 mg/L 3compartmentss NA 95% Rat Human +DTXSID70153355 Css NA 0.08876 mg/L PBTK NA 50% Rat Human +DTXSID70153355 Css NA 0.4237 mg/L PBTK NA 95% Rat Human +DTXSID70156003 Clint 3.424 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70156003 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70156003 Vd NA 3.575 L/kg 1compartment NA NA Human Human +DTXSID70156003 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID70156003 TK.Half.Life NA 31.65 hours 1compartment NA NA Human Human +DTXSID70156003 Css NA 0.7796 mg/L 3compartmentss NA 50% Human Human +DTXSID70156003 Css NA 4.848 mg/L 3compartmentss NA 95% Human Human +DTXSID70156003 Css NA 0.6868 mg/L PBTK NA 50% Human Human +DTXSID70156003 Css NA 3.686 mg/L PBTK NA 95% Human Human +DTXSID70156003 Clint 3.424 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70156003 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70156003 Vd NA 3.123 L/kg 1compartment NA NA Rat Human +DTXSID70156003 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID70156003 TK.Half.Life NA 9.782 hours 1compartment NA NA Rat Human +DTXSID70156003 Css NA 0.03497 mg/L 3compartmentss NA 50% Rat Human +DTXSID70156003 Css NA 0.2435 mg/L 3compartmentss NA 95% Rat Human +DTXSID70156003 Css NA 0.03065 mg/L PBTK NA 50% Rat Human +DTXSID70156003 Css NA 0.1869 mg/L PBTK NA 95% Rat Human +DTXSID70157318 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70157318 Fup 0.779 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70157318 Vd NA 0.5973 L/kg 1compartment NA NA Human Human +DTXSID70157318 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70157318 TK.Half.Life NA 4.969 hours 1compartment NA NA Human Human +DTXSID70157318 Css NA 0.1946 mg/L 3compartmentss NA 50% Human Human +DTXSID70157318 Css NA 1.259 mg/L 3compartmentss NA 95% Human Human +DTXSID70157318 Css NA 0.1507 mg/L PBTK NA 50% Human Human +DTXSID70157318 Css NA 0.8151 mg/L PBTK NA 95% Human Human +DTXSID70157318 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70157318 Fup 0.779 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70157318 Vd NA 0.61 L/kg 1compartment NA NA Rat Human +DTXSID70157318 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70157318 TK.Half.Life NA 1.727 hours 1compartment NA NA Rat Human +DTXSID70157318 Css NA 0.0007778 mg/L 3compartmentss NA 50% Rat Human +DTXSID70157318 Css NA 0.004554 mg/L 3compartmentss NA 95% Rat Human +DTXSID70157318 Css NA 0.0005888 mg/L PBTK NA 50% Rat Human +DTXSID70157318 Css NA 0.002708 mg/L PBTK NA 95% Rat Human +DTXSID70157878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70157878 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70157878 Vd NA 1.266 L/kg 1compartment NA NA Human Human +DTXSID70157878 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID70157878 TK.Half.Life NA 13.14 hours 1compartment NA NA Human Human +DTXSID70157878 Css NA 1.438 mg/L 3compartmentss NA 50% Human Human +DTXSID70157878 Css NA 13.03 mg/L 3compartmentss NA 95% Human Human +DTXSID70157878 Css NA 0.8838 mg/L PBTK NA 50% Human Human +DTXSID70157878 Css NA 7.742 mg/L PBTK NA 95% Human Human +DTXSID70157878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70157878 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70157878 Vd NA 0.9371 L/kg 1compartment NA NA Rat Human +DTXSID70157878 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70157878 TK.Half.Life NA 5.398 hours 1compartment NA NA Rat Human +DTXSID70157878 Css NA 0.0563 mg/L 3compartmentss NA 50% Rat Human +DTXSID70157878 Css NA 0.5835 mg/L 3compartmentss NA 95% Rat Human +DTXSID70157878 Css NA 0.03319 mg/L PBTK NA 50% Rat Human +DTXSID70157878 Css NA 0.3288 mg/L PBTK NA 95% Rat Human +DTXSID70163777 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70163777 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70163777 Vd NA 2.899 L/kg 1compartment NA NA Human Human +DTXSID70163777 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70163777 TK.Half.Life NA 10.61 hours 1compartment NA NA Human Human +DTXSID70163777 Css NA 0.3615 mg/L 3compartmentss NA 50% Human Human +DTXSID70163777 Css NA 2.475 mg/L 3compartmentss NA 95% Human Human +DTXSID70163777 Css NA 0.2693 mg/L PBTK NA 50% Human Human +DTXSID70163777 Css NA 1.705 mg/L PBTK NA 95% Human Human +DTXSID70163777 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70163777 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70163777 Vd NA 2.305 L/kg 1compartment NA NA Rat Human +DTXSID70163777 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70163777 TK.Half.Life NA 2.874 hours 1compartment NA NA Rat Human +DTXSID70163777 Css NA 0.04568 mg/L 3compartmentss NA 50% Rat Human +DTXSID70163777 Css NA 0.249 mg/L 3compartmentss NA 95% Rat Human +DTXSID70163777 Css NA 0.03399 mg/L PBTK NA 50% Rat Human +DTXSID70163777 Css NA 0.1716 mg/L PBTK NA 95% Rat Human +DTXSID70169794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70169794 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70169794 Vd NA 2.376 L/kg 1compartment NA NA Human Human +DTXSID70169794 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70169794 TK.Half.Life NA 8.218 hours 1compartment NA NA Human Human +DTXSID70169794 Css NA 0.3628 mg/L 3compartmentss NA 50% Human Human +DTXSID70169794 Css NA 2.472 mg/L 3compartmentss NA 95% Human Human +DTXSID70169794 Css NA 0.2508 mg/L PBTK NA 50% Human Human +DTXSID70169794 Css NA 1.619 mg/L PBTK NA 95% Human Human +DTXSID70169794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70169794 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70169794 Vd NA 1.799 L/kg 1compartment NA NA Rat Human +DTXSID70169794 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70169794 TK.Half.Life NA 2.343 hours 1compartment NA NA Rat Human +DTXSID70169794 Css NA 0.04698 mg/L 3compartmentss NA 50% Rat Human +DTXSID70169794 Css NA 0.2462 mg/L 3compartmentss NA 95% Rat Human +DTXSID70169794 Css NA 0.03212 mg/L PBTK NA 50% Rat Human +DTXSID70169794 Css NA 0.1593 mg/L PBTK NA 95% Rat Human DTXSID70173593 Clint 17.78 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID70173593 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID70173593 Vd NA 3.273 L/kg 1compartment NA NA Human Human -DTXSID70173593 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID70173593 TK.Half.Life NA 119.8 hours 1compartment NA NA Human Human -DTXSID70173593 Css NA 4.189 mg/L 3compartmentss NA 50% Human Human -DTXSID70173593 Css NA 23.42 mg/L 3compartmentss NA 95% Human Human -DTXSID70173593 Css NA 2.956 mg/L PBTK NA 50% Human Human -DTXSID70173593 Css NA 16.38 mg/L PBTK NA 95% Human Human +DTXSID70173593 Vd NA 6.446 L/kg 1compartment NA NA Human Human +DTXSID70173593 Days.Css NA 47 Days PBTK NA NA Human Human +DTXSID70173593 TK.Half.Life NA 234.6 hours 1compartment NA NA Human Human +DTXSID70173593 Css NA 3.17 mg/L 3compartmentss NA 50% Human Human +DTXSID70173593 Css NA 19.14 mg/L 3compartmentss NA 95% Human Human +DTXSID70173593 Css NA 2.888 mg/L PBTK NA 50% Human Human +DTXSID70173593 Css NA 16.9 mg/L PBTK NA 95% Human Human DTXSID70173593 Clint 17.78 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID70173593 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID70173593 Vd NA 2.456 L/kg 1compartment NA NA Rat Human -DTXSID70173593 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID70173593 TK.Half.Life NA 15.89 hours 1compartment NA NA Rat Human -DTXSID70173593 Css NA 2.382 mg/L 3compartmentss NA 50% Rat Human -DTXSID70173593 Css NA 10.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID70173593 Css NA 1.604 mg/L PBTK NA 50% Rat Human -DTXSID70173593 Css NA 6.857 mg/L PBTK NA 95% Rat Human +DTXSID70173593 Vd NA 4.977 L/kg 1compartment NA NA Rat Human +DTXSID70173593 Days.Css NA 27 Days PBTK NA NA Rat Human +DTXSID70173593 TK.Half.Life NA 31.8 hours 1compartment NA NA Rat Human +DTXSID70173593 Css NA 0.4073 mg/L 3compartmentss NA 50% Rat Human +DTXSID70173593 Css NA 1.908 mg/L 3compartmentss NA 95% Rat Human +DTXSID70173593 Css NA 0.3776 mg/L PBTK NA 50% Rat Human +DTXSID70173593 Css NA 1.796 mg/L PBTK NA 95% Rat Human +DTXSID70175517 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70175517 Fup 0.0795 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70175517 Vd NA 2.096 L/kg 1compartment NA NA Human Human +DTXSID70175517 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70175517 TK.Half.Life NA 8.511 hours 1compartment NA NA Human Human +DTXSID70175517 Css NA 0.4696 mg/L 3compartmentss NA 50% Human Human +DTXSID70175517 Css NA 3.359 mg/L 3compartmentss NA 95% Human Human +DTXSID70175517 Css NA 0.3157 mg/L PBTK NA 50% Human Human +DTXSID70175517 Css NA 2.177 mg/L PBTK NA 95% Human Human +DTXSID70175517 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70175517 Fup 0.0795 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70175517 Vd NA 1.58 L/kg 1compartment NA NA Rat Human +DTXSID70175517 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70175517 TK.Half.Life NA 2.703 hours 1compartment NA NA Rat Human +DTXSID70175517 Css NA 0.06141 mg/L 3compartmentss NA 50% Rat Human +DTXSID70175517 Css NA 0.3343 mg/L 3compartmentss NA 95% Rat Human +DTXSID70175517 Css NA 0.04064 mg/L PBTK NA 50% Rat Human +DTXSID70175517 Css NA 0.2108 mg/L PBTK NA 95% Rat Human +DTXSID70180348 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70180348 Fup 0.887 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70180348 Vd NA 0.7304 L/kg 1compartment NA NA Human Human +DTXSID70180348 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70180348 TK.Half.Life NA 5.332 hours 1compartment NA NA Human Human +DTXSID70180348 Css NA 0.9183 mg/L 3compartmentss NA 50% Human Human +DTXSID70180348 Css NA 5.189 mg/L 3compartmentss NA 95% Human Human +DTXSID70180348 Css NA 0.7534 mg/L PBTK NA 50% Human Human +DTXSID70180348 Css NA 3.382 mg/L PBTK NA 95% Human Human +DTXSID70180348 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70180348 Fup 0.887 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70180348 Vd NA 0.8191 L/kg 1compartment NA NA Rat Human +DTXSID70180348 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70180348 TK.Half.Life NA 1.806 hours 1compartment NA NA Rat Human +DTXSID70180348 Css NA 0.04671 mg/L 3compartmentss NA 50% Rat Human +DTXSID70180348 Css NA 0.2933 mg/L 3compartmentss NA 95% Rat Human +DTXSID70180348 Css NA 0.04004 mg/L PBTK NA 50% Rat Human +DTXSID70180348 Css NA 0.1832 mg/L PBTK NA 95% Rat Human +DTXSID70183137 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70183137 Fup 0.051 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70183137 Vd NA 1.648 L/kg 1compartment NA NA Human Human +DTXSID70183137 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID70183137 TK.Half.Life NA 22.73 hours 1compartment NA NA Human Human +DTXSID70183137 Css NA 2.083 mg/L 3compartmentss NA 50% Human Human +DTXSID70183137 Css NA 13.44 mg/L 3compartmentss NA 95% Human Human +DTXSID70183137 Css NA 1.343 mg/L PBTK NA 50% Human Human +DTXSID70183137 Css NA 8.229 mg/L PBTK NA 95% Human Human +DTXSID70183137 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70183137 Fup 0.051 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70183137 Vd NA 1.241 L/kg 1compartment NA NA Rat Human +DTXSID70183137 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID70183137 TK.Half.Life NA 8.208 hours 1compartment NA NA Rat Human +DTXSID70183137 Css NA 0.2555 mg/L 3compartmentss NA 50% Rat Human +DTXSID70183137 Css NA 1.269 mg/L 3compartmentss NA 95% Rat Human +DTXSID70183137 Css NA 0.1611 mg/L PBTK NA 50% Rat Human +DTXSID70183137 Css NA 0.7542 mg/L PBTK NA 95% Rat Human +DTXSID70190200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70190200 Fup 0.0164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70190200 Vd NA 3.025 L/kg 1compartment NA NA Human Human +DTXSID70190200 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID70190200 TK.Half.Life NA 68.43 hours 1compartment NA NA Human Human +DTXSID70190200 Css NA 2.79 mg/L 3compartmentss NA 50% Human Human +DTXSID70190200 Css NA 18.77 mg/L 3compartmentss NA 95% Human Human +DTXSID70190200 Css NA 1.914 mg/L PBTK NA 50% Human Human +DTXSID70190200 Css NA 12.32 mg/L PBTK NA 95% Human Human +DTXSID70190200 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70190200 Fup 0.0164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70190200 Vd NA 2.264 L/kg 1compartment NA NA Rat Human +DTXSID70190200 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID70190200 TK.Half.Life NA 10.51 hours 1compartment NA NA Rat Human +DTXSID70190200 Css NA 0.3603 mg/L 3compartmentss NA 50% Rat Human +DTXSID70190200 Css NA 2.072 mg/L 3compartmentss NA 95% Rat Human +DTXSID70190200 Css NA 0.2442 mg/L PBTK NA 50% Rat Human +DTXSID70190200 Css NA 1.389 mg/L PBTK NA 95% Rat Human +DTXSID70190563 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70190563 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70190563 Vd NA 0.4464 L/kg 1compartment NA NA Human Human +DTXSID70190563 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID70190563 TK.Half.Life NA 10.42 hours 1compartment NA NA Human Human +DTXSID70190563 Css NA 2.681 mg/L 3compartmentss NA 50% Human Human +DTXSID70190563 Css NA 10.6 mg/L 3compartmentss NA 95% Human Human +DTXSID70190563 Css NA 1.862 mg/L PBTK NA 50% Human Human +DTXSID70190563 Css NA 6.596 mg/L PBTK NA 95% Human Human +DTXSID70190563 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70190563 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70190563 Vd NA 0.3277 L/kg 1compartment NA NA Rat Human +DTXSID70190563 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70190563 TK.Half.Life NA 5.161 hours 1compartment NA NA Rat Human +DTXSID70190563 Css NA 0.4264 mg/L 3compartmentss NA 50% Rat Human +DTXSID70190563 Css NA 1.631 mg/L 3compartmentss NA 95% Rat Human +DTXSID70190563 Css NA 0.262 mg/L PBTK NA 50% Rat Human +DTXSID70190563 Css NA 0.9369 mg/L PBTK NA 95% Rat Human +DTXSID70197375 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70197375 Fup 0.0334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70197375 Vd NA 0.7018 L/kg 1compartment NA NA Human Human +DTXSID70197375 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID70197375 TK.Half.Life NA 11.98 hours 1compartment NA NA Human Human +DTXSID70197375 Css NA 2.978 mg/L 3compartmentss NA 50% Human Human +DTXSID70197375 Css NA 20.03 mg/L 3compartmentss NA 95% Human Human +DTXSID70197375 Css NA 1.814 mg/L PBTK NA 50% Human Human +DTXSID70197375 Css NA 11.92 mg/L PBTK NA 95% Human Human +DTXSID70197375 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70197375 Fup 0.0334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70197375 Vd NA 0.5396 L/kg 1compartment NA NA Rat Human +DTXSID70197375 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70197375 TK.Half.Life NA 5.541 hours 1compartment NA NA Rat Human +DTXSID70197375 Css NA 0.3332 mg/L 3compartmentss NA 50% Rat Human +DTXSID70197375 Css NA 1.815 mg/L 3compartmentss NA 95% Rat Human +DTXSID70197375 Css NA 0.1953 mg/L PBTK NA 50% Rat Human +DTXSID70197375 Css NA 1.035 mg/L PBTK NA 95% Rat Human +DTXSID70197572 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70197572 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70197572 Vd NA 1.149 L/kg 1compartment NA NA Human Human +DTXSID70197572 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70197572 TK.Half.Life NA 1.721 hours 1compartment NA NA Human Human +DTXSID70197572 Css NA 0.1074 mg/L 3compartmentss NA 50% Human Human +DTXSID70197572 Css NA 0.9764 mg/L 3compartmentss NA 95% Human Human +DTXSID70197572 Css NA 0.08964 mg/L PBTK NA 50% Human Human +DTXSID70197572 Css NA 0.6726 mg/L PBTK NA 95% Human Human +DTXSID70197572 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70197572 Fup 0.62 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70197572 Vd NA 1.023 L/kg 1compartment NA NA Rat Human +DTXSID70197572 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70197572 TK.Half.Life NA 0.7967 hours 1compartment NA NA Rat Human +DTXSID70197572 Css NA 0.01219 mg/L 3compartmentss NA 50% Rat Human +DTXSID70197572 Css NA 0.09702 mg/L 3compartmentss NA 95% Rat Human +DTXSID70197572 Css NA 0.01024 mg/L PBTK NA 50% Rat Human +DTXSID70197572 Css NA 0.06182 mg/L PBTK NA 95% Rat Human +DTXSID70199490 Clint 0.4701 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70199490 Fup 0.0498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70199490 Vd NA 2.943 L/kg 1compartment NA NA Human Human +DTXSID70199490 Days.Css NA 283 Days PBTK NA NA Human Human +DTXSID70199490 TK.Half.Life NA 1111 hours 1compartment NA NA Human Human +DTXSID70199490 Css NA 46.06 mg/L 3compartmentss NA 50% Human Human +DTXSID70199490 Css NA 163.6 mg/L 3compartmentss NA 95% Human Human +DTXSID70199490 Css NA 31.84 mg/L PBTK NA 50% Human Human +DTXSID70199490 Css NA 106.2 mg/L PBTK NA 95% Human Human +DTXSID70199490 Clint 0.4701 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70199490 Fup 0.0498 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70199490 Vd NA 2.206 L/kg 1compartment NA NA Rat Human +DTXSID70199490 Days.Css NA 114 Days PBTK NA NA Rat Human +DTXSID70199490 TK.Half.Life NA 140.8 hours 1compartment NA NA Rat Human +DTXSID70199490 Css NA 4.61 mg/L 3compartmentss NA 50% Rat Human +DTXSID70199490 Css NA 11.8 mg/L 3compartmentss NA 95% Rat Human +DTXSID70199490 Css NA 3.144 mg/L PBTK NA 50% Rat Human +DTXSID70199490 Css NA 7.408 mg/L PBTK NA 95% Rat Human DTXSID7020005 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7020005 Fup NA 0.7806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7020005 Vd NA 0.6643 L/kg 1compartment NA NA Human Human DTXSID7020005 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7020005 TK.Half.Life NA 5.51 hours 1compartment NA NA Human Human -DTXSID7020005 Css NA 1.03 mg/L 3compartmentss NA 50% Human Human -DTXSID7020005 Css NA 6.207 mg/L 3compartmentss NA 95% Human Human -DTXSID7020005 Css NA 0.8305 mg/L PBTK NA 50% Human Human -DTXSID7020005 Css NA 4.015 mg/L PBTK NA 95% Human Human +DTXSID7020005 Css NA 0.8792 mg/L 3compartmentss NA 50% Human Human +DTXSID7020005 Css NA 5.546 mg/L 3compartmentss NA 95% Human Human +DTXSID7020005 Css NA 0.7068 mg/L PBTK NA 50% Human Human +DTXSID7020005 Css NA 3.493 mg/L PBTK NA 95% Human Human DTXSID7020005 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7020005 Fup NA 0.7806 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7020005 Vd NA 0.6965 L/kg 1compartment NA NA Rat Human DTXSID7020005 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7020005 TK.Half.Life NA 1.967 hours 1compartment NA NA Rat Human -DTXSID7020005 Css NA 0.2636 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020005 Css NA 1.587 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020005 Css NA 0.2054 mg/L PBTK NA 50% Rat Human -DTXSID7020005 Css NA 0.9401 mg/L PBTK NA 95% Rat Human -DTXSID7020007 Clint NA 2.033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020007 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020007 Vd NA 0.3024 L/kg 1compartment NA NA Human Human +DTXSID7020005 Css NA 0.01644 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020005 Css NA 0.1271 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020005 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID7020005 Css NA 0.08141 mg/L PBTK NA 95% Rat Human +DTXSID7020007 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020007 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020007 Vd NA 0.3766 L/kg 1compartment NA NA Human Human DTXSID7020007 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020007 TK.Half.Life NA 6.89 hours 1compartment NA NA Human Human -DTXSID7020007 Css NA 3.639 mg/L 3compartmentss NA 50% Human Human -DTXSID7020007 Css NA 18.06 mg/L 3compartmentss NA 95% Human Human -DTXSID7020007 Css NA 2.218 mg/L PBTK NA 50% Human Human -DTXSID7020007 Css NA 10.75 mg/L PBTK NA 95% Human Human -DTXSID7020007 Clint NA 2.033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020007 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020007 Vd NA 0.2786 L/kg 1compartment NA NA Rat Human +DTXSID7020007 TK.Half.Life NA 0.8955 hours 1compartment NA NA Human Human +DTXSID7020007 Css NA 0.2466 mg/L 3compartmentss NA 50% Human Human +DTXSID7020007 Css NA 2.026 mg/L 3compartmentss NA 95% Human Human +DTXSID7020007 Css NA 0.154 mg/L PBTK NA 50% Human Human +DTXSID7020007 Css NA 1.226 mg/L PBTK NA 95% Human Human +DTXSID7020007 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020007 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020007 Vd NA 0.3458 L/kg 1compartment NA NA Rat Human DTXSID7020007 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020007 TK.Half.Life NA 3.538 hours 1compartment NA NA Rat Human -DTXSID7020007 Css NA 1.682 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020007 Css NA 6.054 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020007 Css NA 0.96 mg/L PBTK NA 50% Rat Human -DTXSID7020007 Css NA 3.339 mg/L PBTK NA 95% Rat Human -DTXSID7020053 Clint NA 10.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020053 Fup NA 0.4793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020053 Vd NA 1.412 L/kg 1compartment NA NA Human Human +DTXSID7020007 TK.Half.Life NA 0.481 hours 1compartment NA NA Rat Human +DTXSID7020007 Css NA 0.0319 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020007 Css NA 0.2012 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020007 Css NA 0.01947 mg/L PBTK NA 50% Rat Human +DTXSID7020007 Css NA 0.117 mg/L PBTK NA 95% Rat Human +DTXSID7020053 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020053 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020053 Vd NA 1.487 L/kg 1compartment NA NA Human Human DTXSID7020053 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020053 TK.Half.Life NA 1.99 hours 1compartment NA NA Human Human -DTXSID7020053 Css NA 0.08931 mg/L 3compartmentss NA 50% Human Human -DTXSID7020053 Css NA 0.7232 mg/L 3compartmentss NA 95% Human Human -DTXSID7020053 Css NA 0.0738 mg/L PBTK NA 50% Human Human -DTXSID7020053 Css NA 0.5127 mg/L PBTK NA 95% Human Human -DTXSID7020053 Clint NA 10.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020053 Fup NA 0.4793 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020053 Vd NA 1.22 L/kg 1compartment NA NA Rat Human +DTXSID7020053 TK.Half.Life NA 1.88 hours 1compartment NA NA Human Human +DTXSID7020053 Css NA 0.06504 mg/L 3compartmentss NA 50% Human Human +DTXSID7020053 Css NA 0.4773 mg/L 3compartmentss NA 95% Human Human +DTXSID7020053 Css NA 0.05087 mg/L PBTK NA 50% Human Human +DTXSID7020053 Css NA 0.3367 mg/L PBTK NA 95% Human Human +DTXSID7020053 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020053 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020053 Vd NA 1.231 L/kg 1compartment NA NA Rat Human DTXSID7020053 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020053 TK.Half.Life NA 0.8754 hours 1compartment NA NA Rat Human -DTXSID7020053 Css NA 0.04623 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020053 Css NA 0.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020053 Css NA 0.03739 mg/L PBTK NA 50% Rat Human -DTXSID7020053 Css NA 0.1855 mg/L PBTK NA 95% Rat Human -DTXSID7020057 Clint NA 0.9503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020057 Fup NA 0.0654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020057 Vd NA 2.601 L/kg 1compartment NA NA Human Human -DTXSID7020057 Days.Css NA 54 Days PBTK NA NA Human Human -DTXSID7020057 TK.Half.Life NA 253.9 hours 1compartment NA NA Human Human -DTXSID7020057 Css NA 12.84 mg/L 3compartmentss NA 50% Human Human -DTXSID7020057 Css NA 49.12 mg/L 3compartmentss NA 95% Human Human -DTXSID7020057 Css NA 8.786 mg/L PBTK NA 50% Human Human -DTXSID7020057 Css NA 31.67 mg/L PBTK NA 95% Human Human -DTXSID7020057 Clint NA 0.9503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020057 Fup NA 0.0654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020057 Vd NA 1.953 L/kg 1compartment NA NA Rat Human -DTXSID7020057 Days.Css NA 22 Days PBTK NA NA Rat Human -DTXSID7020057 TK.Half.Life NA 46.3 hours 1compartment NA NA Rat Human -DTXSID7020057 Css NA 5.684 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020057 Css NA 15.35 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020057 Css NA 3.698 mg/L PBTK NA 50% Rat Human -DTXSID7020057 Css NA 9.181 mg/L PBTK NA 95% Rat Human -DTXSID7020138 Clint NA 14.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020138 Fup NA 0.1673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020138 Vd NA 0.6041 L/kg 1compartment NA NA Human Human +DTXSID7020053 TK.Half.Life NA 0.7652 hours 1compartment NA NA Rat Human +DTXSID7020053 Css NA 0.008094 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020053 Css NA 0.04629 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020053 Css NA 0.006292 mg/L PBTK NA 50% Rat Human +DTXSID7020053 Css NA 0.0324 mg/L PBTK NA 95% Rat Human +DTXSID7020057 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020057 Fup 0.0339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020057 Vd NA 2.212 L/kg 1compartment NA NA Human Human +DTXSID7020057 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7020057 TK.Half.Life NA 17.18 hours 1compartment NA NA Human Human +DTXSID7020057 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human +DTXSID7020057 Css NA 8.032 mg/L 3compartmentss NA 95% Human Human +DTXSID7020057 Css NA 0.6955 mg/L PBTK NA 50% Human Human +DTXSID7020057 Css NA 4.952 mg/L PBTK NA 95% Human Human +DTXSID7020057 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020057 Fup 0.0339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020057 Vd NA 1.651 L/kg 1compartment NA NA Rat Human +DTXSID7020057 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7020057 TK.Half.Life NA 5.056 hours 1compartment NA NA Rat Human +DTXSID7020057 Css NA 0.138 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020057 Css NA 0.807 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020057 Css NA 0.08864 mg/L PBTK NA 50% Rat Human +DTXSID7020057 Css NA 0.5061 mg/L PBTK NA 95% Rat Human +DTXSID7020138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020138 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020138 Vd NA 0.6774 L/kg 1compartment NA NA Human Human DTXSID7020138 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020138 TK.Half.Life NA 1.428 hours 1compartment NA NA Human Human -DTXSID7020138 Css NA 0.2234 mg/L 3compartmentss NA 50% Human Human -DTXSID7020138 Css NA 1.533 mg/L 3compartmentss NA 95% Human Human -DTXSID7020138 Css NA 0.1482 mg/L PBTK NA 50% Human Human -DTXSID7020138 Css NA 0.9464 mg/L PBTK NA 95% Human Human -DTXSID7020138 Clint NA 14.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020138 Fup NA 0.1673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020138 Vd NA 0.536 L/kg 1compartment NA NA Rat Human +DTXSID7020138 TK.Half.Life NA 1.094 hours 1compartment NA NA Human Human +DTXSID7020138 Css NA 0.1038 mg/L 3compartmentss NA 50% Human Human +DTXSID7020138 Css NA 0.7278 mg/L 3compartmentss NA 95% Human Human +DTXSID7020138 Css NA 0.07108 mg/L PBTK NA 50% Human Human +DTXSID7020138 Css NA 0.4775 mg/L PBTK NA 95% Human Human +DTXSID7020138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020138 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020138 Vd NA 0.6017 L/kg 1compartment NA NA Rat Human DTXSID7020138 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020138 TK.Half.Life NA 0.7298 hours 1compartment NA NA Rat Human -DTXSID7020138 Css NA 0.1206 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020138 Css NA 0.634 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020138 Css NA 0.07572 mg/L PBTK NA 50% Rat Human -DTXSID7020138 Css NA 0.3731 mg/L PBTK NA 95% Rat Human +DTXSID7020138 TK.Half.Life NA 0.5307 hours 1compartment NA NA Rat Human +DTXSID7020138 Css NA 0.01322 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020138 Css NA 0.06897 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020138 Css NA 0.008941 mg/L PBTK NA 50% Rat Human +DTXSID7020138 Css NA 0.04438 mg/L PBTK NA 95% Rat Human DTXSID7020182 Clint 19.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7020182 Fup 0.0385 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7020182 Vd NA 6.337 L/kg 1compartment NA NA Human Human DTXSID7020182 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID7020182 TK.Half.Life NA 39.54 hours 1compartment NA NA Human Human -DTXSID7020182 Css NA 0.6812 mg/L 3compartmentss NA 50% Human Human -DTXSID7020182 Css NA 5.066 mg/L 3compartmentss NA 95% Human Human -DTXSID7020182 Css NA 0.4938 mg/L PBTK NA 50% Human Human -DTXSID7020182 Css NA 3.384 mg/L PBTK NA 95% Human Human +DTXSID7020182 Css NA 0.601 mg/L 3compartmentss NA 50% Human Human +DTXSID7020182 Css NA 4.224 mg/L 3compartmentss NA 95% Human Human +DTXSID7020182 Css NA 0.4776 mg/L PBTK NA 50% Human Human +DTXSID7020182 Css NA 3.357 mg/L PBTK NA 95% Human Human DTXSID7020182 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID7020182 Fup 0.7181 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID7020182 Vd NA 12.66 L/kg 1compartment NA NA Rat Rat +DTXSID7020182 Vd 1.4 12.66 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID7020182 Days.Css NA 112 Days PBTK NA NA Rat Rat -DTXSID7020182 TK.Half.Life NA 139.5 hours 1compartment NA NA Rat Rat -DTXSID7020182 Css NA 4.043 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7020182 Css NA 8.907 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7020182 Css NA 2.264 mg/L PBTK NA 50% Rat Rat -DTXSID7020182 Css NA 4.892 mg/L PBTK NA 95% Rat Rat +DTXSID7020182 TK.Half.Life 0.19 139.5 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID7020182 Css 0.0083 0.6436 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID7020182 Css 0.0083 1.353 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID7020182 Css 0.0083 0.5297 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID7020182 Css 0.0083 1.114 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID7020184 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7020184 Fup NA 0.0073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020184 Vd NA 0.7903 L/kg 1compartment NA NA Human Human -DTXSID7020184 Days.Css NA 204 Days PBTK NA NA Human Human -DTXSID7020184 TK.Half.Life NA 780.6 hours 1compartment NA NA Human Human -DTXSID7020184 Css NA 166.2 mg/L 3compartmentss NA 50% Human Human -DTXSID7020184 Css NA 962.3 mg/L 3compartmentss NA 95% Human Human -DTXSID7020184 Css NA 98.91 mg/L PBTK NA 50% Human Human -DTXSID7020184 Css NA 556.6 mg/L PBTK NA 95% Human Human +DTXSID7020184 Vd NA 0.165 L/kg 1compartment NA NA Human Human +DTXSID7020184 Days.Css NA 33 Days PBTK NA NA Human Human +DTXSID7020184 TK.Half.Life NA 146.2 hours 1compartment NA NA Human Human +DTXSID7020184 Css NA 130.6 mg/L 3compartmentss NA 50% Human Human +DTXSID7020184 Css NA 817.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7020184 Css NA 76.12 mg/L PBTK NA 50% Human Human +DTXSID7020184 Css NA 473.6 mg/L PBTK NA 95% Human Human DTXSID7020184 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7020184 Fup NA 0.0073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020184 Vd NA 0.5838 L/kg 1compartment NA NA Rat Human -DTXSID7020184 Days.Css NA 46 Days PBTK NA NA Rat Human -DTXSID7020184 TK.Half.Life NA 181.1 hours 1compartment NA NA Rat Human -DTXSID7020184 Css NA 47.04 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020184 Css NA 232.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020184 Css NA 26.16 mg/L PBTK NA 50% Rat Human -DTXSID7020184 Css NA 126.3 mg/L PBTK NA 95% Rat Human -DTXSID7020211 Clint NA 64.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020211 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020211 Vd NA 2.838 L/kg 1compartment NA NA Human Human +DTXSID7020184 Vd NA 0.164 L/kg 1compartment NA NA Rat Human +DTXSID7020184 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID7020184 TK.Half.Life NA 49.55 hours 1compartment NA NA Rat Human +DTXSID7020184 Css NA 2.48 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020184 Css NA 20.02 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020184 Css NA 1.36 mg/L PBTK NA 50% Rat Human +DTXSID7020184 Css NA 11.05 mg/L PBTK NA 95% Rat Human +DTXSID7020211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020211 Fup 0.0772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020211 Vd NA 1.948 L/kg 1compartment NA NA Human Human DTXSID7020211 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020211 TK.Half.Life NA 12.5 hours 1compartment NA NA Human Human -DTXSID7020211 Css NA 0.504 mg/L 3compartmentss NA 50% Human Human -DTXSID7020211 Css NA 3.31 mg/L 3compartmentss NA 95% Human Human -DTXSID7020211 Css NA 0.342 mg/L PBTK NA 50% Human Human -DTXSID7020211 Css NA 2.154 mg/L PBTK NA 95% Human Human -DTXSID7020211 Clint NA 64.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020211 Fup NA 0.0408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020211 Vd NA 2.126 L/kg 1compartment NA NA Rat Human +DTXSID7020211 TK.Half.Life NA 7.603 hours 1compartment NA NA Human Human +DTXSID7020211 Css NA 0.4598 mg/L 3compartmentss NA 50% Human Human +DTXSID7020211 Css NA 3.165 mg/L 3compartmentss NA 95% Human Human +DTXSID7020211 Css NA 0.3076 mg/L PBTK NA 50% Human Human +DTXSID7020211 Css NA 2.01 mg/L PBTK NA 95% Human Human +DTXSID7020211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020211 Fup 0.0772 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020211 Vd NA 1.469 L/kg 1compartment NA NA Rat Human DTXSID7020211 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020211 TK.Half.Life NA 2.638 hours 1compartment NA NA Rat Human -DTXSID7020211 Css NA 0.2792 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020211 Css NA 1.599 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020211 Css NA 0.182 mg/L PBTK NA 50% Rat Human -DTXSID7020211 Css NA 0.9967 mg/L PBTK NA 95% Rat Human -DTXSID7020213 Clint NA 0.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020213 Fup NA 0.3188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020213 Vd NA 0.4111 L/kg 1compartment NA NA Human Human +DTXSID7020211 TK.Half.Life NA 2.554 hours 1compartment NA NA Rat Human +DTXSID7020211 Css NA 0.05943 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020211 Css NA 0.3278 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020211 Css NA 0.03897 mg/L PBTK NA 50% Rat Human +DTXSID7020211 Css NA 0.2042 mg/L PBTK NA 95% Rat Human +DTXSID7020213 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020213 Fup 0.563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020213 Vd NA 0.5322 L/kg 1compartment NA NA Human Human DTXSID7020213 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020213 TK.Half.Life NA 4.252 hours 1compartment NA NA Human Human -DTXSID7020213 Css NA 1.183 mg/L 3compartmentss NA 50% Human Human -DTXSID7020213 Css NA 5.125 mg/L 3compartmentss NA 95% Human Human -DTXSID7020213 Css NA 0.8217 mg/L PBTK NA 50% Human Human -DTXSID7020213 Css NA 3.157 mg/L PBTK NA 95% Human Human -DTXSID7020213 Clint NA 0.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020213 Fup NA 0.3188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020213 Vd NA 0.4278 L/kg 1compartment NA NA Rat Human +DTXSID7020213 TK.Half.Life NA 6.118 hours 1compartment NA NA Human Human +DTXSID7020213 Css NA 1.149 mg/L 3compartmentss NA 50% Human Human +DTXSID7020213 Css NA 7.908 mg/L 3compartmentss NA 95% Human Human +DTXSID7020213 Css NA 0.8778 mg/L PBTK NA 50% Human Human +DTXSID7020213 Css NA 4.857 mg/L PBTK NA 95% Human Human +DTXSID7020213 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020213 Fup 0.563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020213 Vd NA 0.5609 L/kg 1compartment NA NA Rat Human DTXSID7020213 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020213 TK.Half.Life NA 2.007 hours 1compartment NA NA Rat Human -DTXSID7020213 Css NA 0.4464 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020213 Css NA 1.597 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020213 Css NA 0.2936 mg/L PBTK NA 50% Rat Human -DTXSID7020213 Css NA 0.9241 mg/L PBTK NA 95% Rat Human -DTXSID7020215 Clint NA 41.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020215 Fup NA 0.105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020215 Vd NA 2.352 L/kg 1compartment NA NA Human Human -DTXSID7020215 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020215 TK.Half.Life NA 5.691 hours 1compartment NA NA Human Human -DTXSID7020215 Css NA 0.2314 mg/L 3compartmentss NA 50% Human Human -DTXSID7020215 Css NA 1.581 mg/L 3compartmentss NA 95% Human Human -DTXSID7020215 Css NA 0.1585 mg/L PBTK NA 50% Human Human -DTXSID7020215 Css NA 1.034 mg/L PBTK NA 95% Human Human -DTXSID7020215 Clint NA 41.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020215 Fup NA 0.105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020215 Vd NA 1.776 L/kg 1compartment NA NA Rat Human -DTXSID7020215 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020215 TK.Half.Life NA 1.675 hours 1compartment NA NA Rat Human -DTXSID7020215 Css NA 0.1296 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020215 Css NA 0.7256 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020215 Css NA 0.0846 mg/L PBTK NA 50% Rat Human -DTXSID7020215 Css NA 0.4559 mg/L PBTK NA 95% Rat Human +DTXSID7020213 TK.Half.Life NA 2.196 hours 1compartment NA NA Rat Human +DTXSID7020213 Css NA 0.0218 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020213 Css NA 0.1858 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020213 Css NA 0.01599 mg/L PBTK NA 50% Rat Human +DTXSID7020213 Css NA 0.1138 mg/L PBTK NA 95% Rat Human DTXSID7020261 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7020261 Fup NA 0.625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7020261 Vd NA 0.5765 L/kg 1compartment NA NA Human Human DTXSID7020261 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7020261 TK.Half.Life NA 5.97 hours 1compartment NA NA Human Human -DTXSID7020261 Css NA 1.203 mg/L 3compartmentss NA 50% Human Human -DTXSID7020261 Css NA 7.913 mg/L 3compartmentss NA 95% Human Human -DTXSID7020261 Css NA 0.9488 mg/L PBTK NA 50% Human Human -DTXSID7020261 Css NA 4.975 mg/L PBTK NA 95% Human Human +DTXSID7020261 Css NA 1.164 mg/L 3compartmentss NA 50% Human Human +DTXSID7020261 Css NA 7.896 mg/L 3compartmentss NA 95% Human Human +DTXSID7020261 Css NA 0.9214 mg/L PBTK NA 50% Human Human +DTXSID7020261 Css NA 4.961 mg/L PBTK NA 95% Human Human DTXSID7020261 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7020261 Fup NA 0.625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7020261 Vd NA 0.5843 L/kg 1compartment NA NA Rat Human DTXSID7020261 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7020261 TK.Half.Life NA 2.061 hours 1compartment NA NA Rat Human -DTXSID7020261 Css NA 0.3202 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020261 Css NA 2.075 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020261 Css NA 0.2421 mg/L PBTK NA 50% Rat Human -DTXSID7020261 Css NA 1.21 mg/L PBTK NA 95% Rat Human -DTXSID7020263 Clint NA 8.792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7020261 Css NA 0.07137 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020261 Css NA 0.4606 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020261 Css NA 0.05599 mg/L PBTK NA 50% Rat Human +DTXSID7020261 Css NA 0.2786 mg/L PBTK NA 95% Rat Human +DTXSID7020263 Clint 44 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID7020263 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7020263 Vd NA 0.1733 L/kg 1compartment NA NA Human Human DTXSID7020263 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020263 TK.Half.Life NA 7.343 hours 1compartment NA NA Human Human -DTXSID7020263 Css NA 7.977 mg/L 3compartmentss NA 50% Human Human -DTXSID7020263 Css NA 71.67 mg/L 3compartmentss NA 95% Human Human -DTXSID7020263 Css NA 4.643 mg/L PBTK NA 50% Human Human -DTXSID7020263 Css NA 41.8 mg/L PBTK NA 95% Human Human -DTXSID7020263 Clint NA 8.792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7020263 TK.Half.Life NA 1.681 hours 1compartment NA NA Human Human +DTXSID7020263 Css NA 1.66 mg/L 3compartmentss NA 50% Human Human +DTXSID7020263 Css NA 17.16 mg/L 3compartmentss NA 95% Human Human +DTXSID7020263 Css NA 0.9655 mg/L PBTK NA 50% Human Human +DTXSID7020263 Css NA 10.02 mg/L PBTK NA 95% Human Human +DTXSID7020263 Clint 44 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID7020263 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7020263 Vd NA 0.1703 L/kg 1compartment NA NA Rat Human DTXSID7020263 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020263 TK.Half.Life NA 4.702 hours 1compartment NA NA Rat Human -DTXSID7020263 Css NA 4.396 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020263 Css NA 30.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020263 Css NA 2.39 mg/L PBTK NA 50% Rat Human -DTXSID7020263 Css NA 16.49 mg/L PBTK NA 95% Rat Human +DTXSID7020263 TK.Half.Life NA 1.1 hours 1compartment NA NA Rat Human +DTXSID7020263 Css NA 0.222 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020263 Css NA 1.929 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020263 Css NA 0.125 mg/L PBTK NA 50% Rat Human +DTXSID7020263 Css NA 1.083 mg/L PBTK NA 95% Rat Human DTXSID7020265 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID7020265 Fup 0.34 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7020265 Vd NA 0.782 L/kg 1compartment NA NA Human Human DTXSID7020265 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7020265 TK.Half.Life NA 7.095 hours 1compartment NA NA Human Human -DTXSID7020265 Css NA 0.9662 mg/L 3compartmentss NA 50% Human Human -DTXSID7020265 Css NA 4.511 mg/L 3compartmentss NA 95% Human Human -DTXSID7020265 Css NA 0.7234 mg/L PBTK NA 50% Human Human -DTXSID7020265 Css NA 2.922 mg/L PBTK NA 95% Human Human +DTXSID7020265 Css NA 0.9387 mg/L 3compartmentss NA 50% Human Human +DTXSID7020265 Css NA 4.197 mg/L 3compartmentss NA 95% Human Human +DTXSID7020265 Css NA 0.7028 mg/L PBTK NA 50% Human Human +DTXSID7020265 Css NA 2.729 mg/L PBTK NA 95% Human Human DTXSID7020265 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID7020265 Fup 0.34 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7020265 Vd NA 0.7146 L/kg 1compartment NA NA Rat Human DTXSID7020265 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7020265 TK.Half.Life NA 2.962 hours 1compartment NA NA Rat Human -DTXSID7020265 Css NA 0.3741 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020265 Css NA 1.421 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020265 Css NA 0.2672 mg/L PBTK NA 50% Rat Human -DTXSID7020265 Css NA 0.8529 mg/L PBTK NA 95% Rat Human -DTXSID7020340 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020340 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020340 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID7020340 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020340 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID7020340 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID7020340 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID7020340 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID7020340 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID7020340 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020340 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020340 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human -DTXSID7020340 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020340 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID7020340 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020340 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020340 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID7020340 Css NA 1.296 mg/L PBTK NA 95% Rat Human -DTXSID7020342 Clint NA 1222 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020342 Fup NA 0.4277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020342 Vd NA 2.457 L/kg 1compartment NA NA Human Human +DTXSID7020265 Css NA 0.08416 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020265 Css NA 0.3211 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020265 Css NA 0.06208 mg/L PBTK NA 50% Rat Human +DTXSID7020265 Css NA 0.1989 mg/L PBTK NA 95% Rat Human +DTXSID7020342 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020342 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020342 Vd NA 1.85 L/kg 1compartment NA NA Human Human DTXSID7020342 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020342 TK.Half.Life NA 1.268 hours 1compartment NA NA Human Human -DTXSID7020342 Css NA 0.0006485 mg/L 3compartmentss NA 50% Human Human -DTXSID7020342 Css NA 0.006339 mg/L 3compartmentss NA 95% Human Human -DTXSID7020342 Css NA 0.0006636 mg/L PBTK NA 50% Human Human -DTXSID7020342 Css NA 0.005191 mg/L PBTK NA 95% Human Human -DTXSID7020342 Clint NA 1222 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020342 Fup NA 0.4277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020342 Vd NA 2.481 L/kg 1compartment NA NA Rat Human +DTXSID7020342 TK.Half.Life NA 4.557 hours 1compartment NA NA Human Human +DTXSID7020342 Css NA 0.1856 mg/L 3compartmentss NA 50% Human Human +DTXSID7020342 Css NA 1.265 mg/L 3compartmentss NA 95% Human Human +DTXSID7020342 Css NA 0.1629 mg/L PBTK NA 50% Human Human +DTXSID7020342 Css NA 0.928 mg/L PBTK NA 95% Human Human +DTXSID7020342 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020342 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020342 Vd NA 1.856 L/kg 1compartment NA NA Rat Human DTXSID7020342 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020342 TK.Half.Life NA 0.5608 hours 1compartment NA NA Rat Human -DTXSID7020342 Css NA 0.0003391 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020342 Css NA 0.002815 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020342 Css NA 0.0003477 mg/L PBTK NA 50% Rat Human -DTXSID7020342 Css NA 0.002266 mg/L PBTK NA 95% Rat Human -DTXSID7020344 Clint NA 1.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020344 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020344 Vd NA 0.3578 L/kg 1compartment NA NA Human Human -DTXSID7020344 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7020344 TK.Half.Life NA 27.58 hours 1compartment NA NA Human Human -DTXSID7020344 Css NA 13.52 mg/L 3compartmentss NA 50% Human Human -DTXSID7020344 Css NA 97.57 mg/L 3compartmentss NA 95% Human Human -DTXSID7020344 Css NA 8.135 mg/L PBTK NA 50% Human Human -DTXSID7020344 Css NA 56.42 mg/L PBTK NA 95% Human Human -DTXSID7020344 Clint NA 1.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020344 Fup NA 0.0222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020344 Vd NA 0.302 L/kg 1compartment NA NA Rat Human -DTXSID7020344 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7020344 TK.Half.Life NA 12.65 hours 1compartment NA NA Rat Human -DTXSID7020344 Css NA 6.184 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020344 Css NA 36.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020344 Css NA 3.463 mg/L PBTK NA 50% Rat Human -DTXSID7020344 Css NA 19.92 mg/L PBTK NA 95% Rat Human +DTXSID7020342 TK.Half.Life NA 2.679 hours 1compartment NA NA Rat Human +DTXSID7020342 Css NA 0.02159 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020342 Css NA 0.1102 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020342 Css NA 0.01928 mg/L PBTK NA 50% Rat Human +DTXSID7020342 Css NA 0.08024 mg/L PBTK NA 95% Rat Human +DTXSID7020344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020344 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020344 Vd NA 0.7766 L/kg 1compartment NA NA Human Human +DTXSID7020344 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7020344 TK.Half.Life NA 1.833 hours 1compartment NA NA Human Human +DTXSID7020344 Css NA 0.2356 mg/L 3compartmentss NA 50% Human Human +DTXSID7020344 Css NA 2.027 mg/L 3compartmentss NA 95% Human Human +DTXSID7020344 Css NA 0.1592 mg/L PBTK NA 50% Human Human +DTXSID7020344 Css NA 1.265 mg/L PBTK NA 95% Human Human +DTXSID7020344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020344 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020344 Vd NA 0.6466 L/kg 1compartment NA NA Rat Human +DTXSID7020344 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7020344 TK.Half.Life NA 0.8732 hours 1compartment NA NA Rat Human +DTXSID7020344 Css NA 0.03023 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020344 Css NA 0.1997 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020344 Css NA 0.01994 mg/L PBTK NA 50% Rat Human +DTXSID7020344 Css NA 0.1218 mg/L PBTK NA 95% Rat Human DTXSID7020348 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7020348 Fup 0.1922 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7020348 Vd NA 0.6699 L/kg 1compartment NA NA Human Human DTXSID7020348 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID7020348 TK.Half.Life NA 23.32 hours 1compartment NA NA Human Human -DTXSID7020348 Css NA 4.181 mg/L 3compartmentss NA 50% Human Human -DTXSID7020348 Css NA 15.29 mg/L 3compartmentss NA 95% Human Human -DTXSID7020348 Css NA 2.843 mg/L PBTK NA 50% Human Human -DTXSID7020348 Css NA 9.571 mg/L PBTK NA 95% Human Human +DTXSID7020348 Css NA 4.015 mg/L 3compartmentss NA 50% Human Human +DTXSID7020348 Css NA 14.66 mg/L 3compartmentss NA 95% Human Human +DTXSID7020348 Css NA 2.755 mg/L PBTK NA 50% Human Human +DTXSID7020348 Css NA 9.106 mg/L PBTK NA 95% Human Human DTXSID7020348 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7020348 Fup 0.1922 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7020348 Vd NA 0.5901 L/kg 1compartment NA NA Rat Human DTXSID7020348 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7020348 TK.Half.Life NA 6.829 hours 1compartment NA NA Rat Human -DTXSID7020348 Css NA 1.155 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020348 Css NA 3.362 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020348 Css NA 0.7467 mg/L PBTK NA 50% Rat Human -DTXSID7020348 Css NA 1.952 mg/L PBTK NA 95% Rat Human -DTXSID7020390 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020390 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020390 Vd NA 0.7737 L/kg 1compartment NA NA Human Human +DTXSID7020348 Css NA 0.2629 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020348 Css NA 0.7952 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020348 Css NA 0.1759 mg/L PBTK NA 50% Rat Human +DTXSID7020348 Css NA 0.477 mg/L PBTK NA 95% Rat Human +DTXSID7020390 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020390 Fup 0.883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020390 Vd NA 0.7045 L/kg 1compartment NA NA Human Human DTXSID7020390 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020390 TK.Half.Life NA 5.008 hours 1compartment NA NA Human Human -DTXSID7020390 Css NA 0.83 mg/L 3compartmentss NA 50% Human Human -DTXSID7020390 Css NA 5.566 mg/L 3compartmentss NA 95% Human Human -DTXSID7020390 Css NA 0.6988 mg/L PBTK NA 50% Human Human -DTXSID7020390 Css NA 3.648 mg/L PBTK NA 95% Human Human -DTXSID7020390 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020390 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020390 Vd NA 0.8119 L/kg 1compartment NA NA Rat Human +DTXSID7020390 TK.Half.Life NA 5.165 hours 1compartment NA NA Human Human +DTXSID7020390 Css NA 0.8084 mg/L 3compartmentss NA 50% Human Human +DTXSID7020390 Css NA 4.517 mg/L 3compartmentss NA 95% Human Human +DTXSID7020390 Css NA 0.6608 mg/L PBTK NA 50% Human Human +DTXSID7020390 Css NA 2.948 mg/L PBTK NA 95% Human Human +DTXSID7020390 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020390 Fup 0.883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020390 Vd NA 0.7416 L/kg 1compartment NA NA Rat Human DTXSID7020390 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020390 TK.Half.Life NA 1.791 hours 1compartment NA NA Rat Human -DTXSID7020390 Css NA 0.2083 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020390 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020390 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID7020390 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID7020390 TK.Half.Life NA 1.852 hours 1compartment NA NA Rat Human +DTXSID7020390 Css NA 0.01518 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020390 Css NA 0.1088 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020390 Css NA 0.01179 mg/L PBTK NA 50% Rat Human +DTXSID7020390 Css NA 0.0701 mg/L PBTK NA 95% Rat Human DTXSID7020392 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7020392 Fup 0.9621 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7020392 Vd NA 3.104 L/kg 1compartment NA NA Human Human DTXSID7020392 Days.Css NA 58 Days PBTK NA NA Human Human DTXSID7020392 TK.Half.Life NA 269.8 hours 1compartment NA NA Human Human -DTXSID7020392 Css NA 9.019 mg/L 3compartmentss NA 50% Human Human -DTXSID7020392 Css NA 26.31 mg/L 3compartmentss NA 95% Human Human -DTXSID7020392 Css NA 6.933 mg/L PBTK NA 50% Human Human -DTXSID7020392 Css NA 18.09 mg/L PBTK NA 95% Human Human +DTXSID7020392 Css NA 8.734 mg/L 3compartmentss NA 50% Human Human +DTXSID7020392 Css NA 25.28 mg/L 3compartmentss NA 95% Human Human +DTXSID7020392 Css NA 6.732 mg/L PBTK NA 50% Human Human +DTXSID7020392 Css NA 17.53 mg/L PBTK NA 95% Human Human DTXSID7020392 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7020392 Fup 0.9621 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7020392 Vd NA 2.373 L/kg 1compartment NA NA Rat Human DTXSID7020392 Days.Css NA 14 Days PBTK NA NA Rat Human DTXSID7020392 TK.Half.Life NA 20.9 hours 1compartment NA NA Rat Human -DTXSID7020392 Css NA 2.432 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020392 Css NA 5.655 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020392 Css NA 1.81 mg/L PBTK NA 50% Rat Human -DTXSID7020392 Css NA 3.63 mg/L PBTK NA 95% Rat Human -DTXSID7020398 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020398 Fup NA 0.9008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020398 Vd NA 1.135 L/kg 1compartment NA NA Human Human +DTXSID7020392 Css NA 0.5516 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020392 Css NA 1.257 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020392 Css NA 0.4245 mg/L PBTK NA 50% Rat Human +DTXSID7020392 Css NA 0.8374 mg/L PBTK NA 95% Rat Human +DTXSID7020398 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020398 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020398 Vd NA 0.6928 L/kg 1compartment NA NA Human Human DTXSID7020398 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020398 TK.Half.Life NA 0.7178 hours 1compartment NA NA Human Human -DTXSID7020398 Css NA 0.01361 mg/L 3compartmentss NA 50% Human Human -DTXSID7020398 Css NA 0.1072 mg/L 3compartmentss NA 95% Human Human -DTXSID7020398 Css NA 0.01193 mg/L PBTK NA 50% Human Human -DTXSID7020398 Css NA 0.08173 mg/L PBTK NA 95% Human Human -DTXSID7020398 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020398 Fup NA 0.9008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020398 Vd NA 1.11 L/kg 1compartment NA NA Rat Human +DTXSID7020398 TK.Half.Life NA 6.762 hours 1compartment NA NA Human Human +DTXSID7020398 Css NA 1.094 mg/L 3compartmentss NA 50% Human Human +DTXSID7020398 Css NA 7.34 mg/L 3compartmentss NA 95% Human Human +DTXSID7020398 Css NA 0.8886 mg/L PBTK NA 50% Human Human +DTXSID7020398 Css NA 4.651 mg/L PBTK NA 95% Human Human +DTXSID7020398 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020398 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020398 Vd NA 0.7125 L/kg 1compartment NA NA Rat Human DTXSID7020398 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020398 TK.Half.Life NA 0.3251 hours 1compartment NA NA Rat Human -DTXSID7020398 Css NA 0.00697 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020398 Css NA 0.04716 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020398 Css NA 0.00615 mg/L PBTK NA 50% Rat Human -DTXSID7020398 Css NA 0.03652 mg/L PBTK NA 95% Rat Human -DTXSID7020421 Clint NA 5.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020421 Fup NA 0.7281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020421 Vd NA 1.311 L/kg 1compartment NA NA Human Human -DTXSID7020421 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020421 TK.Half.Life NA 1.799 hours 1compartment NA NA Human Human -DTXSID7020421 Css NA 0.1021 mg/L 3compartmentss NA 50% Human Human -DTXSID7020421 Css NA 0.8601 mg/L 3compartmentss NA 95% Human Human -DTXSID7020421 Css NA 0.08976 mg/L PBTK NA 50% Human Human -DTXSID7020421 Css NA 0.6164 mg/L PBTK NA 95% Human Human -DTXSID7020421 Clint NA 5.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020421 Fup NA 0.7281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020421 Vd NA 1.188 L/kg 1compartment NA NA Rat Human -DTXSID7020421 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020421 TK.Half.Life NA 0.8396 hours 1compartment NA NA Rat Human -DTXSID7020421 Css NA 0.048 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020421 Css NA 0.3799 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020421 Css NA 0.04219 mg/L PBTK NA 50% Rat Human -DTXSID7020421 Css NA 0.24 mg/L PBTK NA 95% Rat Human -DTXSID7020423 Clint NA 0.002948 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020423 Fup NA 0.5072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020423 Vd NA 0.5922 L/kg 1compartment NA NA Human Human +DTXSID7020398 TK.Half.Life NA 2.366 hours 1compartment NA NA Rat Human +DTXSID7020398 Css NA 0.06635 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020398 Css NA 0.4207 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020398 Css NA 0.05318 mg/L PBTK NA 50% Rat Human +DTXSID7020398 Css NA 0.2565 mg/L PBTK NA 95% Rat Human +DTXSID7020423 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020423 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020423 Vd NA 0.5485 L/kg 1compartment NA NA Human Human DTXSID7020423 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020423 TK.Half.Life NA 7.515 hours 1compartment NA NA Human Human -DTXSID7020423 Css NA 1.408 mg/L 3compartmentss NA 50% Human Human -DTXSID7020423 Css NA 7.623 mg/L 3compartmentss NA 95% Human Human -DTXSID7020423 Css NA 1.089 mg/L PBTK NA 50% Human Human -DTXSID7020423 Css NA 4.777 mg/L PBTK NA 95% Human Human -DTXSID7020423 Clint NA 0.002948 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020423 Fup NA 0.5072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020423 Vd NA 0.6102 L/kg 1compartment NA NA Rat Human +DTXSID7020423 TK.Half.Life NA 9.289 hours 1compartment NA NA Human Human +DTXSID7020423 Css NA 1.572 mg/L 3compartmentss NA 50% Human Human +DTXSID7020423 Css NA 7.097 mg/L 3compartmentss NA 95% Human Human +DTXSID7020423 Css NA 1.174 mg/L PBTK NA 50% Human Human +DTXSID7020423 Css NA 4.541 mg/L PBTK NA 95% Human Human +DTXSID7020423 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020423 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020423 Vd NA 0.5594 L/kg 1compartment NA NA Rat Human DTXSID7020423 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020423 TK.Half.Life NA 2.646 hours 1compartment NA NA Rat Human -DTXSID7020423 Css NA 0.3872 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020423 Css NA 1.883 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020423 Css NA 0.2857 mg/L PBTK NA 50% Rat Human -DTXSID7020423 Css NA 1.113 mg/L PBTK NA 95% Rat Human -DTXSID7020427 Clint NA 2.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020427 Fup NA 0.2949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020427 Vd NA 1.248 L/kg 1compartment NA NA Human Human +DTXSID7020423 TK.Half.Life NA 3.228 hours 1compartment NA NA Rat Human +DTXSID7020423 Css NA 0.02868 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020423 Css NA 0.1877 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020423 Css NA 0.02049 mg/L PBTK NA 50% Rat Human +DTXSID7020423 Css NA 0.1197 mg/L PBTK NA 95% Rat Human +DTXSID7020425 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020425 Fup 0.0462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020425 Vd NA 1.196 L/kg 1compartment NA NA Human Human +DTXSID7020425 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7020425 TK.Half.Life NA 5.649 hours 1compartment NA NA Human Human +DTXSID7020425 Css NA 0.6537 mg/L 3compartmentss NA 50% Human Human +DTXSID7020425 Css NA 4.846 mg/L 3compartmentss NA 95% Human Human +DTXSID7020425 Css NA 0.4098 mg/L PBTK NA 50% Human Human +DTXSID7020425 Css NA 2.956 mg/L PBTK NA 95% Human Human +DTXSID7020425 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020425 Fup 0.0462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020425 Vd NA 0.9039 L/kg 1compartment NA NA Rat Human +DTXSID7020425 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7020425 TK.Half.Life NA 2.363 hours 1compartment NA NA Rat Human +DTXSID7020425 Css NA 0.0846 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020425 Css NA 0.5102 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020425 Css NA 0.0519 mg/L PBTK NA 50% Rat Human +DTXSID7020425 Css NA 0.303 mg/L PBTK NA 95% Rat Human +DTXSID7020427 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020427 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020427 Vd NA 0.886 L/kg 1compartment NA NA Human Human DTXSID7020427 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020427 TK.Half.Life NA 6.365 hours 1compartment NA NA Human Human -DTXSID7020427 Css NA 0.5277 mg/L 3compartmentss NA 50% Human Human -DTXSID7020427 Css NA 2.714 mg/L 3compartmentss NA 95% Human Human -DTXSID7020427 Css NA 0.3964 mg/L PBTK NA 50% Human Human -DTXSID7020427 Css NA 1.814 mg/L PBTK NA 95% Human Human -DTXSID7020427 Clint NA 2.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020427 Fup NA 0.2949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020427 Vd NA 1.033 L/kg 1compartment NA NA Rat Human +DTXSID7020427 TK.Half.Life NA 3.168 hours 1compartment NA NA Human Human +DTXSID7020427 Css NA 0.3515 mg/L 3compartmentss NA 50% Human Human +DTXSID7020427 Css NA 2.056 mg/L 3compartmentss NA 95% Human Human +DTXSID7020427 Css NA 0.2444 mg/L PBTK NA 50% Human Human +DTXSID7020427 Css NA 1.328 mg/L PBTK NA 95% Human Human +DTXSID7020427 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020427 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020427 Vd NA 0.7462 L/kg 1compartment NA NA Rat Human DTXSID7020427 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020427 TK.Half.Life NA 2.652 hours 1compartment NA NA Rat Human -DTXSID7020427 Css NA 0.249 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020427 Css NA 0.9635 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020427 Css NA 0.1799 mg/L PBTK NA 50% Rat Human -DTXSID7020427 Css NA 0.5963 mg/L PBTK NA 95% Rat Human +DTXSID7020427 TK.Half.Life NA 1.504 hours 1compartment NA NA Rat Human +DTXSID7020427 Css NA 0.0417 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020427 Css NA 0.1768 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020427 Css NA 0.02867 mg/L PBTK NA 50% Rat Human +DTXSID7020427 Css NA 0.1124 mg/L PBTK NA 95% Rat Human +DTXSID7020475 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020475 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020475 Vd NA 1.279 L/kg 1compartment NA NA Human Human +DTXSID7020475 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7020475 TK.Half.Life NA 2.96 hours 1compartment NA NA Human Human +DTXSID7020475 Css NA 0.222 mg/L 3compartmentss NA 50% Human Human +DTXSID7020475 Css NA 1.822 mg/L 3compartmentss NA 95% Human Human +DTXSID7020475 Css NA 0.1483 mg/L PBTK NA 50% Human Human +DTXSID7020475 Css NA 1.133 mg/L PBTK NA 95% Human Human +DTXSID7020475 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020475 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020475 Vd NA 0.9981 L/kg 1compartment NA NA Rat Human +DTXSID7020475 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7020475 TK.Half.Life NA 1.213 hours 1compartment NA NA Rat Human +DTXSID7020475 Css NA 0.02842 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020475 Css NA 0.1802 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020475 Css NA 0.01873 mg/L PBTK NA 50% Rat Human +DTXSID7020475 Css NA 0.1104 mg/L PBTK NA 95% Rat Human DTXSID7020479 Clint 3.682 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7020479 Fup 0.9649 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7020479 Vd NA 1.21 L/kg 1compartment NA NA Human Human DTXSID7020479 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7020479 TK.Half.Life NA 1.647 hours 1compartment NA NA Human Human -DTXSID7020479 Css NA 0.121 mg/L 3compartmentss NA 50% Human Human -DTXSID7020479 Css NA 0.8708 mg/L 3compartmentss NA 95% Human Human -DTXSID7020479 Css NA 0.1083 mg/L PBTK NA 50% Human Human -DTXSID7020479 Css NA 0.643 mg/L PBTK NA 95% Human Human +DTXSID7020479 Css NA 0.1171 mg/L 3compartmentss NA 50% Human Human +DTXSID7020479 Css NA 0.8735 mg/L 3compartmentss NA 95% Human Human +DTXSID7020479 Css NA 0.1049 mg/L PBTK NA 50% Human Human +DTXSID7020479 Css NA 0.6199 mg/L PBTK NA 95% Human Human DTXSID7020479 Clint 3.682 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7020479 Fup 0.9649 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7020479 Vd NA 1.161 L/kg 1compartment NA NA Rat Human DTXSID7020479 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7020479 TK.Half.Life NA 0.8187 hours 1compartment NA NA Rat Human -DTXSID7020479 Css NA 0.05464 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020479 Css NA 0.3651 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020479 Css NA 0.04891 mg/L PBTK NA 50% Rat Human -DTXSID7020479 Css NA 0.2392 mg/L PBTK NA 95% Rat Human +DTXSID7020479 Css NA 0.01225 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020479 Css NA 0.08464 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020479 Css NA 0.01129 mg/L PBTK NA 50% Rat Human +DTXSID7020479 Css NA 0.05687 mg/L PBTK NA 95% Rat Human DTXSID7020504 Clint 4.1 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID7020504 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID7020504 Vd NA 1.373 L/kg 1compartment NA NA Human Human +DTXSID7020504 Vd NA 1.366 L/kg 1compartment NA NA Human Human DTXSID7020504 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020504 TK.Half.Life NA 1.736 hours 1compartment NA NA Human Human -DTXSID7020504 Css NA 0.1004 mg/L 3compartmentss NA 50% Human Human -DTXSID7020504 Css NA 0.9197 mg/L 3compartmentss NA 95% Human Human -DTXSID7020504 Css NA 0.09352 mg/L PBTK NA 50% Human Human -DTXSID7020504 Css NA 0.6939 mg/L PBTK NA 95% Human Human +DTXSID7020504 TK.Half.Life NA 1.726 hours 1compartment NA NA Human Human +DTXSID7020504 Css NA 0.09542 mg/L 3compartmentss NA 50% Human Human +DTXSID7020504 Css NA 0.8755 mg/L 3compartmentss NA 95% Human Human +DTXSID7020504 Css NA 0.08892 mg/L PBTK NA 50% Human Human +DTXSID7020504 Css NA 0.6509 mg/L PBTK NA 95% Human Human DTXSID7020504 Clint 4.1 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID7020504 Fup 1 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human -DTXSID7020504 Vd NA 1.286 L/kg 1compartment NA NA Rat Human +DTXSID7020504 Vd NA 1.281 L/kg 1compartment NA NA Rat Human DTXSID7020504 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020504 TK.Half.Life NA 0.83 hours 1compartment NA NA Rat Human -DTXSID7020504 Css NA 0.04522 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020504 Css NA 0.337 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020504 Css NA 0.04233 mg/L PBTK NA 50% Rat Human -DTXSID7020504 Css NA 0.22 mg/L PBTK NA 95% Rat Human -DTXSID7020508 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7020508 Fup 0.9058 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7020508 Vd NA 0.6209 L/kg 1compartment NA NA Human Human -DTXSID7020508 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020508 TK.Half.Life NA 4.446 hours 1compartment NA NA Human Human -DTXSID7020508 Css NA 0.9754 mg/L 3compartmentss NA 50% Human Human -DTXSID7020508 Css NA 5.557 mg/L 3compartmentss NA 95% Human Human -DTXSID7020508 Css NA 0.77 mg/L PBTK NA 50% Human Human -DTXSID7020508 Css NA 3.445 mg/L PBTK NA 95% Human Human -DTXSID7020508 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7020508 Fup 0.9058 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7020508 Vd NA 0.6286 L/kg 1compartment NA NA Rat Human -DTXSID7020508 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020508 TK.Half.Life NA 1.531 hours 1compartment NA NA Rat Human -DTXSID7020508 Css NA 0.2514 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020508 Css NA 1.358 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020508 Css NA 0.1909 mg/L PBTK NA 50% Rat Human -DTXSID7020508 Css NA 0.8042 mg/L PBTK NA 95% Rat Human -DTXSID7020550 Clint NA 2.576 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020550 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020550 Vd NA 1.989 L/kg 1compartment NA NA Human Human -DTXSID7020550 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020550 TK.Half.Life NA 3.026 hours 1compartment NA NA Human Human -DTXSID7020550 Css NA 0.1348 mg/L 3compartmentss NA 50% Human Human -DTXSID7020550 Css NA 1.172 mg/L 3compartmentss NA 95% Human Human -DTXSID7020550 Css NA 0.1373 mg/L PBTK NA 50% Human Human -DTXSID7020550 Css NA 0.8921 mg/L PBTK NA 95% Human Human -DTXSID7020550 Clint NA 2.576 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020550 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020550 Vd NA 2.032 L/kg 1compartment NA NA Rat Human +DTXSID7020504 TK.Half.Life NA 0.8267 hours 1compartment NA NA Rat Human +DTXSID7020504 Css NA 0.009931 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020504 Css NA 0.07306 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020504 Css NA 0.00965 mg/L PBTK NA 50% Rat Human +DTXSID7020504 Css NA 0.05161 mg/L PBTK NA 95% Rat Human +DTXSID7020550 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020550 Fup 0.755 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020550 Vd NA 1.692 L/kg 1compartment NA NA Human Human +DTXSID7020550 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7020550 TK.Half.Life NA 14.5 hours 1compartment NA NA Human Human +DTXSID7020550 Css NA 0.8418 mg/L 3compartmentss NA 50% Human Human +DTXSID7020550 Css NA 5.963 mg/L 3compartmentss NA 95% Human Human +DTXSID7020550 Css NA 0.8156 mg/L PBTK NA 50% Human Human +DTXSID7020550 Css NA 4.043 mg/L PBTK NA 95% Human Human +DTXSID7020550 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020550 Fup 0.755 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020550 Vd NA 1.723 L/kg 1compartment NA NA Rat Human DTXSID7020550 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020550 TK.Half.Life NA 1.639 hours 1compartment NA NA Rat Human -DTXSID7020550 Css NA 0.05673 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020550 Css NA 0.4226 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020550 Css NA 0.05906 mg/L PBTK NA 50% Rat Human -DTXSID7020550 Css NA 0.2846 mg/L PBTK NA 95% Rat Human -DTXSID7020552 Clint NA 8.388 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020552 Fup NA 0.194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020552 Vd NA 3.914 L/kg 1compartment NA NA Human Human +DTXSID7020550 TK.Half.Life NA 5.03 hours 1compartment NA NA Rat Human +DTXSID7020550 Css NA 0.04937 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020550 Css NA 0.3545 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020550 Css NA 0.04891 mg/L PBTK NA 50% Rat Human +DTXSID7020550 Css NA 0.2306 mg/L PBTK NA 95% Rat Human +DTXSID7020552 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020552 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020552 Vd NA 1.414 L/kg 1compartment NA NA Human Human DTXSID7020552 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020552 TK.Half.Life NA 7.78 hours 1compartment NA NA Human Human -DTXSID7020552 Css NA 0.1165 mg/L 3compartmentss NA 50% Human Human -DTXSID7020552 Css NA 0.877 mg/L 3compartmentss NA 95% Human Human -DTXSID7020552 Css NA 0.1369 mg/L PBTK NA 50% Human Human -DTXSID7020552 Css NA 0.8453 mg/L PBTK NA 95% Human Human -DTXSID7020552 Clint NA 8.388 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020552 Fup NA 0.194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020552 Vd NA 3.913 L/kg 1compartment NA NA Rat Human +DTXSID7020552 TK.Half.Life NA 2.971 hours 1compartment NA NA Human Human +DTXSID7020552 Css NA 0.1576 mg/L 3compartmentss NA 50% Human Human +DTXSID7020552 Css NA 1.052 mg/L 3compartmentss NA 95% Human Human +DTXSID7020552 Css NA 0.1326 mg/L PBTK NA 50% Human Human +DTXSID7020552 Css NA 0.7703 mg/L PBTK NA 95% Human Human +DTXSID7020552 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020552 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020552 Vd NA 1.419 L/kg 1compartment NA NA Rat Human DTXSID7020552 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020552 TK.Half.Life NA 4.455 hours 1compartment NA NA Rat Human -DTXSID7020552 Css NA 0.05916 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020552 Css NA 0.3426 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020552 Css NA 0.07123 mg/L PBTK NA 50% Rat Human -DTXSID7020552 Css NA 0.31 mg/L PBTK NA 95% Rat Human -DTXSID7020558 Clint NA 61.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020558 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020558 Vd NA 1.717 L/kg 1compartment NA NA Human Human +DTXSID7020552 TK.Half.Life NA 1.707 hours 1compartment NA NA Rat Human +DTXSID7020552 Css NA 0.01829 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020552 Css NA 0.09169 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020552 Css NA 0.01557 mg/L PBTK NA 50% Rat Human +DTXSID7020552 Css NA 0.06316 mg/L PBTK NA 95% Rat Human +DTXSID7020558 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020558 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020558 Vd NA 3.266 L/kg 1compartment NA NA Human Human DTXSID7020558 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020558 TK.Half.Life NA 2.115 hours 1compartment NA NA Human Human -DTXSID7020558 Css NA 0.07852 mg/L 3compartmentss NA 50% Human Human -DTXSID7020558 Css NA 0.8034 mg/L 3compartmentss NA 95% Human Human -DTXSID7020558 Css NA 0.06024 mg/L PBTK NA 50% Human Human -DTXSID7020558 Css NA 0.5417 mg/L PBTK NA 95% Human Human -DTXSID7020558 Clint NA 61.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020558 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020558 Vd NA 1.683 L/kg 1compartment NA NA Rat Human +DTXSID7020558 TK.Half.Life NA 3.508 hours 1compartment NA NA Human Human +DTXSID7020558 Css NA 0.05566 mg/L 3compartmentss NA 50% Human Human +DTXSID7020558 Css NA 0.5841 mg/L 3compartmentss NA 95% Human Human +DTXSID7020558 Css NA 0.05958 mg/L PBTK NA 50% Human Human +DTXSID7020558 Css NA 0.479 mg/L PBTK NA 95% Human Human +DTXSID7020558 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020558 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020558 Vd NA 3.25 L/kg 1compartment NA NA Rat Human DTXSID7020558 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020558 TK.Half.Life NA 1.133 hours 1compartment NA NA Rat Human -DTXSID7020558 Css NA 0.0449 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020558 Css NA 0.3568 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020558 Css NA 0.03284 mg/L PBTK NA 50% Rat Human -DTXSID7020558 Css NA 0.229 mg/L PBTK NA 95% Rat Human -DTXSID7020631 Clint NA 8.786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020631 Fup NA 0.0795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020631 Vd NA 1.853 L/kg 1compartment NA NA Human Human -DTXSID7020631 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7020631 TK.Half.Life NA 14.23 hours 1compartment NA NA Human Human -DTXSID7020631 Css NA 1.07 mg/L 3compartmentss NA 50% Human Human -DTXSID7020631 Css NA 7.022 mg/L 3compartmentss NA 95% Human Human -DTXSID7020631 Css NA 0.7065 mg/L PBTK NA 50% Human Human -DTXSID7020631 Css NA 4.401 mg/L PBTK NA 95% Human Human -DTXSID7020631 Clint NA 8.786 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020631 Fup NA 0.0795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020631 Vd NA 1.4 L/kg 1compartment NA NA Rat Human +DTXSID7020558 TK.Half.Life NA 1.964 hours 1compartment NA NA Rat Human +DTXSID7020558 Css NA 0.007101 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020558 Css NA 0.06004 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020558 Css NA 0.007674 mg/L PBTK NA 50% Rat Human +DTXSID7020558 Css NA 0.04962 mg/L PBTK NA 95% Rat Human +DTXSID7020631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020631 Fup 0.0721 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020631 Vd NA 1.529 L/kg 1compartment NA NA Human Human +DTXSID7020631 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7020631 TK.Half.Life NA 5.532 hours 1compartment NA NA Human Human +DTXSID7020631 Css NA 0.4296 mg/L 3compartmentss NA 50% Human Human +DTXSID7020631 Css NA 3.225 mg/L 3compartmentss NA 95% Human Human +DTXSID7020631 Css NA 0.2786 mg/L PBTK NA 50% Human Human +DTXSID7020631 Css NA 2.007 mg/L PBTK NA 95% Human Human +DTXSID7020631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020631 Fup 0.0721 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020631 Vd NA 1.158 L/kg 1compartment NA NA Rat Human DTXSID7020631 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020631 TK.Half.Life NA 4.861 hours 1compartment NA NA Rat Human -DTXSID7020631 Css NA 0.5739 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020631 Css NA 2.756 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020631 Css NA 0.3606 mg/L PBTK NA 50% Rat Human -DTXSID7020631 Css NA 1.635 mg/L PBTK NA 95% Rat Human -DTXSID7020635 Clint NA 24.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020635 Fup NA 0.0597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020635 Vd NA 1.205 L/kg 1compartment NA NA Human Human +DTXSID7020631 TK.Half.Life NA 2.12 hours 1compartment NA NA Rat Human +DTXSID7020631 Css NA 0.05635 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020631 Css NA 0.3218 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020631 Css NA 0.03592 mg/L PBTK NA 50% Rat Human +DTXSID7020631 Css NA 0.1961 mg/L PBTK NA 95% Rat Human +DTXSID7020635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020635 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020635 Vd NA 2.334 L/kg 1compartment NA NA Human Human DTXSID7020635 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020635 TK.Half.Life NA 2.314 hours 1compartment NA NA Human Human -DTXSID7020635 Css NA 0.1806 mg/L 3compartmentss NA 50% Human Human -DTXSID7020635 Css NA 1.624 mg/L 3compartmentss NA 95% Human Human -DTXSID7020635 Css NA 0.1326 mg/L PBTK NA 50% Human Human -DTXSID7020635 Css NA 1.062 mg/L PBTK NA 95% Human Human -DTXSID7020635 Clint NA 24.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020635 Fup NA 0.0597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020635 Vd NA 1.166 L/kg 1compartment NA NA Rat Human +DTXSID7020635 TK.Half.Life NA 2.226 hours 1compartment NA NA Human Human +DTXSID7020635 Css NA 0.04479 mg/L 3compartmentss NA 50% Human Human +DTXSID7020635 Css NA 0.4533 mg/L 3compartmentss NA 95% Human Human +DTXSID7020635 Css NA 0.0429 mg/L PBTK NA 50% Human Human +DTXSID7020635 Css NA 0.3572 mg/L PBTK NA 95% Human Human +DTXSID7020635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020635 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020635 Vd NA 2.275 L/kg 1compartment NA NA Rat Human DTXSID7020635 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020635 TK.Half.Life NA 1.328 hours 1compartment NA NA Rat Human -DTXSID7020635 Css NA 0.1026 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020635 Css NA 0.7585 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020635 Css NA 0.07131 mg/L PBTK NA 50% Rat Human -DTXSID7020635 Css NA 0.4711 mg/L PBTK NA 95% Rat Human -DTXSID7020681 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020681 Fup NA 0.5525 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020681 Vd NA 3.202 L/kg 1compartment NA NA Human Human -DTXSID7020681 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020681 TK.Half.Life NA 4.542 hours 1compartment NA NA Human Human -DTXSID7020681 Css NA 0.08091 mg/L 3compartmentss NA 50% Human Human -DTXSID7020681 Css NA 0.9288 mg/L 3compartmentss NA 95% Human Human -DTXSID7020681 Css NA 0.106 mg/L PBTK NA 50% Human Human -DTXSID7020681 Css NA 0.7598 mg/L PBTK NA 95% Human Human -DTXSID7020681 Clint NA 5.042 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020681 Fup NA 0.5525 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020681 Vd NA 3.176 L/kg 1compartment NA NA Rat Human -DTXSID7020681 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020681 TK.Half.Life NA 2.596 hours 1compartment NA NA Rat Human -DTXSID7020681 Css NA 0.03788 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020681 Css NA 0.3908 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020681 Css NA 0.05024 mg/L PBTK NA 50% Rat Human -DTXSID7020681 Css NA 0.2923 mg/L PBTK NA 95% Rat Human +DTXSID7020635 TK.Half.Life NA 1.179 hours 1compartment NA NA Rat Human +DTXSID7020635 Css NA 0.005723 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020635 Css NA 0.05001 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020635 Css NA 0.00557 mg/L PBTK NA 50% Rat Human +DTXSID7020635 Css NA 0.03901 mg/L PBTK NA 95% Rat Human DTXSID7020685 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7020685 Fup NA 0.0566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7020685 Vd NA 2.489 L/kg 1compartment NA NA Human Human -DTXSID7020685 Days.Css NA 227 Days PBTK NA NA Human Human +DTXSID7020685 Days.Css NA 228 Days PBTK NA NA Human Human DTXSID7020685 TK.Half.Life NA 901.4 hours 1compartment NA NA Human Human -DTXSID7020685 Css NA 47.86 mg/L 3compartmentss NA 50% Human Human -DTXSID7020685 Css NA 152.5 mg/L 3compartmentss NA 95% Human Human -DTXSID7020685 Css NA 32.38 mg/L PBTK NA 50% Human Human -DTXSID7020685 Css NA 96.29 mg/L PBTK NA 95% Human Human +DTXSID7020685 Css NA 41.12 mg/L 3compartmentss NA 50% Human Human +DTXSID7020685 Css NA 134.1 mg/L 3compartmentss NA 95% Human Human +DTXSID7020685 Css NA 27.74 mg/L PBTK NA 50% Human Human +DTXSID7020685 Css NA 84.68 mg/L PBTK NA 95% Human Human DTXSID7020685 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7020685 Fup NA 0.0566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7020685 Vd NA 1.866 L/kg 1compartment NA NA Rat Human -DTXSID7020685 Days.Css NA 55 Days PBTK NA NA Rat Human +DTXSID7020685 Days.Css NA 56 Days PBTK NA NA Rat Human DTXSID7020685 TK.Half.Life NA 110.3 hours 1compartment NA NA Rat Human -DTXSID7020685 Css NA 13.06 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020685 Css NA 34.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020685 Css NA 8.383 mg/L PBTK NA 50% Rat Human -DTXSID7020685 Css NA 20.19 mg/L PBTK NA 95% Rat Human +DTXSID7020685 Css NA 0.9982 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020685 Css NA 4.562 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020685 Css NA 0.6427 mg/L PBTK NA 50% Rat Human +DTXSID7020685 Css NA 2.828 mg/L PBTK NA 95% Rat Human DTXSID7020687 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7020687 Fup 0.0174 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7020687 Vd NA 1.763 L/kg 1compartment NA NA Human Human -DTXSID7020687 Days.Css NA 284 Days PBTK NA NA Human Human +DTXSID7020687 Days.Css NA 281 Days PBTK NA NA Human Human DTXSID7020687 TK.Half.Life NA 1092 hours 1compartment NA NA Human Human -DTXSID7020687 Css NA 58.68 mg/L 3compartmentss NA 50% Human Human -DTXSID7020687 Css NA 196.3 mg/L 3compartmentss NA 95% Human Human -DTXSID7020687 Css NA 38.39 mg/L PBTK NA 50% Human Human -DTXSID7020687 Css NA 121 mg/L PBTK NA 95% Human Human +DTXSID7020687 Css NA 49.64 mg/L 3compartmentss NA 50% Human Human +DTXSID7020687 Css NA 175.7 mg/L 3compartmentss NA 95% Human Human +DTXSID7020687 Css NA 32.51 mg/L PBTK NA 50% Human Human +DTXSID7020687 Css NA 107.1 mg/L PBTK NA 95% Human Human DTXSID7020687 Clint 73.4 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID7020687 Fup 0.009 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID7020687 Vd NA 0.9854 L/kg 1compartment NA NA Rat Rat DTXSID7020687 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID7020687 TK.Half.Life NA 2.93 hours 1compartment NA NA Rat Rat -DTXSID7020687 Css NA 0.4632 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7020687 Css NA 3.93 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7020687 Css NA 0.2666 mg/L PBTK NA 50% Rat Rat -DTXSID7020687 Css NA 2.176 mg/L PBTK NA 95% Rat Rat +DTXSID7020687 Css NA 0.03686 mg/L 3compartmentss NA 50% Rat Rat +DTXSID7020687 Css NA 0.3782 mg/L 3compartmentss NA 95% Rat Rat +DTXSID7020687 Css NA 0.02163 mg/L PBTK NA 50% Rat Rat +DTXSID7020687 Css NA 0.2156 mg/L PBTK NA 95% Rat Rat DTXSID7020714 Clint 8.567 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7020714 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7020714 Vd NA 0.7944 L/kg 1compartment NA NA Human Human DTXSID7020714 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7020714 TK.Half.Life NA 2.282 hours 1compartment NA NA Human Human -DTXSID7020714 Css NA 0.2699 mg/L 3compartmentss NA 50% Human Human -DTXSID7020714 Css NA 1.633 mg/L 3compartmentss NA 95% Human Human -DTXSID7020714 Css NA 0.1877 mg/L PBTK NA 50% Human Human -DTXSID7020714 Css NA 1.062 mg/L PBTK NA 95% Human Human +DTXSID7020714 Css NA 0.2629 mg/L 3compartmentss NA 50% Human Human +DTXSID7020714 Css NA 1.63 mg/L 3compartmentss NA 95% Human Human +DTXSID7020714 Css NA 0.1813 mg/L PBTK NA 50% Human Human +DTXSID7020714 Css NA 1.059 mg/L PBTK NA 95% Human Human DTXSID7020714 Clint 8.567 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID7020714 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7020714 Vd NA 0.68 L/kg 1compartment NA NA Rat Human DTXSID7020714 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7020714 TK.Half.Life NA 1.112 hours 1compartment NA NA Rat Human -DTXSID7020714 Css NA 0.1432 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020714 Css NA 0.6513 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020714 Css NA 0.09448 mg/L PBTK NA 50% Rat Human -DTXSID7020714 Css NA 0.3951 mg/L PBTK NA 95% Rat Human -DTXSID7020716 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020716 Fup NA 0.9315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020716 Vd NA 1.092 L/kg 1compartment NA NA Human Human +DTXSID7020714 Css NA 0.03145 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020714 Css NA 0.1451 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020714 Css NA 0.02142 mg/L PBTK NA 50% Rat Human +DTXSID7020714 Css NA 0.09149 mg/L PBTK NA 95% Rat Human +DTXSID7020716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020716 Fup 0.577 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020716 Vd NA 0.8198 L/kg 1compartment NA NA Human Human DTXSID7020716 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020716 TK.Half.Life NA 1.216 hours 1compartment NA NA Human Human -DTXSID7020716 Css NA 0.08098 mg/L 3compartmentss NA 50% Human Human -DTXSID7020716 Css NA 0.4887 mg/L 3compartmentss NA 95% Human Human -DTXSID7020716 Css NA 0.07134 mg/L PBTK NA 50% Human Human -DTXSID7020716 Css NA 0.3757 mg/L PBTK NA 95% Human Human -DTXSID7020716 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020716 Fup NA 0.9315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020716 Vd NA 1.065 L/kg 1compartment NA NA Rat Human +DTXSID7020716 TK.Half.Life NA 0.7511 hours 1compartment NA NA Human Human +DTXSID7020716 Css NA 0.02718 mg/L 3compartmentss NA 50% Human Human +DTXSID7020716 Css NA 0.3259 mg/L 3compartmentss NA 95% Human Human +DTXSID7020716 Css NA 0.022 mg/L PBTK NA 50% Human Human +DTXSID7020716 Css NA 0.2201 mg/L PBTK NA 95% Human Human +DTXSID7020716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020716 Fup 0.577 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020716 Vd NA 0.7965 L/kg 1compartment NA NA Rat Human DTXSID7020716 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020716 TK.Half.Life NA 0.6172 hours 1compartment NA NA Rat Human -DTXSID7020716 Css NA 0.03803 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020716 Css NA 0.1687 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020716 Css NA 0.03362 mg/L PBTK NA 50% Rat Human -DTXSID7020716 Css NA 0.1278 mg/L PBTK NA 95% Rat Human -DTXSID7020760 Clint NA 43.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7020716 TK.Half.Life NA 0.3629 hours 1compartment NA NA Rat Human +DTXSID7020716 Css NA 0.0009808 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020716 Css NA 0.01338 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020716 Css NA 0.0007813 mg/L PBTK NA 50% Rat Human +DTXSID7020716 Css NA 0.008918 mg/L PBTK NA 95% Rat Human +DTXSID70207342 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70207342 Fup 0.0358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70207342 Vd NA 1.495 L/kg 1compartment NA NA Human Human +DTXSID70207342 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID70207342 TK.Half.Life NA 50.34 hours 1compartment NA NA Human Human +DTXSID70207342 Css NA 5.161 mg/L 3compartmentss NA 50% Human Human +DTXSID70207342 Css NA 28.14 mg/L 3compartmentss NA 95% Human Human +DTXSID70207342 Css NA 3.268 mg/L PBTK NA 50% Human Human +DTXSID70207342 Css NA 17.12 mg/L PBTK NA 95% Human Human +DTXSID70207342 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70207342 Fup 0.0358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70207342 Vd NA 1.122 L/kg 1compartment NA NA Rat Human +DTXSID70207342 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID70207342 TK.Half.Life NA 18.05 hours 1compartment NA NA Rat Human +DTXSID70207342 Css NA 0.6016 mg/L 3compartmentss NA 50% Rat Human +DTXSID70207342 Css NA 2.355 mg/L 3compartmentss NA 95% Rat Human +DTXSID70207342 Css NA 0.372 mg/L PBTK NA 50% Rat Human +DTXSID70207342 Css NA 1.38 mg/L PBTK NA 95% Rat Human +DTXSID7020760 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7020760 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7020760 Vd NA 1.19 L/kg 1compartment NA NA Human Human DTXSID7020760 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020760 TK.Half.Life NA 0.7086 hours 1compartment NA NA Human Human -DTXSID7020760 Css NA 0.01127 mg/L 3compartmentss NA 50% Human Human -DTXSID7020760 Css NA 0.156 mg/L 3compartmentss NA 95% Human Human -DTXSID7020760 Css NA 0.01004 mg/L PBTK NA 50% Human Human -DTXSID7020760 Css NA 0.1198 mg/L PBTK NA 95% Human Human -DTXSID7020760 Clint NA 43.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7020760 TK.Half.Life NA 8.039 hours 1compartment NA NA Human Human +DTXSID7020760 Css NA 0.7465 mg/L 3compartmentss NA 50% Human Human +DTXSID7020760 Css NA 5.488 mg/L 3compartmentss NA 95% Human Human +DTXSID7020760 Css NA 0.6806 mg/L PBTK NA 50% Human Human +DTXSID7020760 Css NA 3.661 mg/L PBTK NA 95% Human Human +DTXSID7020760 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7020760 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7020760 Vd NA 1.137 L/kg 1compartment NA NA Rat Human DTXSID7020760 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020760 TK.Half.Life NA 0.3086 hours 1compartment NA NA Rat Human -DTXSID7020760 Css NA 0.005666 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020760 Css NA 0.06563 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020760 Css NA 0.00505 mg/L PBTK NA 50% Rat Human -DTXSID7020760 Css NA 0.04879 mg/L PBTK NA 95% Rat Human +DTXSID7020760 TK.Half.Life NA 2.533 hours 1compartment NA NA Rat Human +DTXSID7020760 Css NA 0.04332 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020760 Css NA 0.2902 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020760 Css NA 0.04048 mg/L PBTK NA 50% Rat Human +DTXSID7020760 Css NA 0.1861 mg/L PBTK NA 95% Rat Human DTXSID7020762 Clint 1.102 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID7020762 Fup 0.9214 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID7020762 Vd NA 0.9115 L/kg 1compartment NA NA Human Human DTXSID7020762 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7020762 TK.Half.Life NA 2.496 hours 1compartment NA NA Human Human -DTXSID7020762 Css NA 0.3187 mg/L 3compartmentss NA 50% Human Human -DTXSID7020762 Css NA 2.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7020762 Css NA 0.2711 mg/L PBTK NA 50% Human Human -DTXSID7020762 Css NA 1.402 mg/L PBTK NA 95% Human Human +DTXSID7020762 Css NA 0.2713 mg/L 3compartmentss NA 50% Human Human +DTXSID7020762 Css NA 1.74 mg/L 3compartmentss NA 95% Human Human +DTXSID7020762 Css NA 0.2307 mg/L PBTK NA 50% Human Human +DTXSID7020762 Css NA 1.184 mg/L PBTK NA 95% Human Human DTXSID7020762 Clint 5.972 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID7020762 Fup 0.6696 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID7020762 Vd NA 0.7571 L/kg 1compartment NA NA Rat Rat DTXSID7020762 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID7020762 TK.Half.Life NA 0.5724 hours 1compartment NA NA Rat Rat -DTXSID7020762 Css NA 0.05181 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7020762 Css NA 0.4103 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7020762 Css NA 0.04134 mg/L PBTK NA 50% Rat Rat -DTXSID7020762 Css NA 0.2503 mg/L PBTK NA 95% Rat Rat +DTXSID7020762 Css NA 0.003072 mg/L 3compartmentss NA 50% Rat Rat +DTXSID7020762 Css NA 0.03257 mg/L 3compartmentss NA 95% Rat Rat +DTXSID7020762 Css NA 0.002438 mg/L PBTK NA 50% Rat Rat +DTXSID7020762 Css NA 0.02115 mg/L PBTK NA 95% Rat Rat DTXSID7020764 Clint 78.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7020764 Fup 0.0833 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7020764 Vd NA 2.456 L/kg 1compartment NA NA Human Human DTXSID7020764 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7020764 TK.Half.Life NA 4.909 hours 1compartment NA NA Human Human -DTXSID7020764 Css NA 0.1536 mg/L 3compartmentss NA 50% Human Human -DTXSID7020764 Css NA 1.922 mg/L 3compartmentss NA 95% Human Human -DTXSID7020764 Css NA 0.09304 mg/L PBTK NA 50% Human Human -DTXSID7020764 Css NA 1.156 mg/L PBTK NA 95% Human Human +DTXSID7020764 Css NA 0.1386 mg/L 3compartmentss NA 50% Human Human +DTXSID7020764 Css NA 1.785 mg/L 3compartmentss NA 95% Human Human +DTXSID7020764 Css NA 0.08917 mg/L PBTK NA 50% Human Human +DTXSID7020764 Css NA 1.149 mg/L PBTK NA 95% Human Human DTXSID7020764 Clint 24.78 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID7020764 Fup 0.03279 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID7020764 Vd NA 1.399 L/kg 1compartment NA NA Rat Rat DTXSID7020764 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID7020764 TK.Half.Life NA 3.997 hours 1compartment NA NA Rat Rat -DTXSID7020764 Css NA 0.5342 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7020764 Css NA 3.381 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7020764 Css NA 0.3107 mg/L PBTK NA 50% Rat Rat -DTXSID7020764 Css NA 1.907 mg/L PBTK NA 95% Rat Rat -DTXSID7020766 Clint NA 9.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020766 Fup NA 0.1615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020766 Vd NA 1.674 L/kg 1compartment NA NA Human Human +DTXSID7020764 Css NA 0.1078 mg/L 3compartmentss NA 50% Rat Rat +DTXSID7020764 Css NA 0.6857 mg/L 3compartmentss NA 95% Rat Rat +DTXSID7020764 Css NA 0.07182 mg/L PBTK NA 50% Rat Rat +DTXSID7020764 Css NA 0.4569 mg/L PBTK NA 95% Rat Rat +DTXSID7020766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020766 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020766 Vd NA 1.613 L/kg 1compartment NA NA Human Human DTXSID7020766 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020766 TK.Half.Life NA 6.156 hours 1compartment NA NA Human Human -DTXSID7020766 Css NA 0.3935 mg/L 3compartmentss NA 50% Human Human -DTXSID7020766 Css NA 2.496 mg/L 3compartmentss NA 95% Human Human -DTXSID7020766 Css NA 0.2745 mg/L PBTK NA 50% Human Human -DTXSID7020766 Css NA 1.646 mg/L PBTK NA 95% Human Human -DTXSID7020766 Clint NA 9.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020766 Fup NA 0.1615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020766 Vd NA 1.296 L/kg 1compartment NA NA Rat Human +DTXSID7020766 TK.Half.Life NA 3.595 hours 1compartment NA NA Human Human +DTXSID7020766 Css NA 0.2006 mg/L 3compartmentss NA 50% Human Human +DTXSID7020766 Css NA 1.533 mg/L 3compartmentss NA 95% Human Human +DTXSID7020766 Css NA 0.1386 mg/L PBTK NA 50% Human Human +DTXSID7020766 Css NA 0.9814 mg/L PBTK NA 95% Human Human +DTXSID7020766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020766 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020766 Vd NA 1.247 L/kg 1compartment NA NA Rat Human DTXSID7020766 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020766 TK.Half.Life NA 2.299 hours 1compartment NA NA Rat Human -DTXSID7020766 Css NA 0.2124 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020766 Css NA 0.9892 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020766 Css NA 0.1408 mg/L PBTK NA 50% Rat Human -DTXSID7020766 Css NA 0.6163 mg/L PBTK NA 95% Rat Human -DTXSID7020768 Clint NA 6.445 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020768 Fup NA 0.0311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020768 Vd NA 0.2178 L/kg 1compartment NA NA Human Human +DTXSID7020766 TK.Half.Life NA 1.36 hours 1compartment NA NA Rat Human +DTXSID7020766 Css NA 0.0257 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020766 Css NA 0.155 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020766 Css NA 0.01738 mg/L PBTK NA 50% Rat Human +DTXSID7020766 Css NA 0.09949 mg/L PBTK NA 95% Rat Human +DTXSID7020768 Clint 95.7 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID7020768 Fup 0.0381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020768 Vd NA 0.2139 L/kg 1compartment NA NA Human Human DTXSID7020768 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020768 TK.Half.Life NA 4.028 hours 1compartment NA NA Human Human -DTXSID7020768 Css NA 3.341 mg/L 3compartmentss NA 50% Human Human -DTXSID7020768 Css NA 28.95 mg/L 3compartmentss NA 95% Human Human -DTXSID7020768 Css NA 1.97 mg/L PBTK NA 50% Human Human -DTXSID7020768 Css NA 16.76 mg/L PBTK NA 95% Human Human +DTXSID7020768 TK.Half.Life NA 0.4303 hours 1compartment NA NA Human Human +DTXSID7020768 Css NA 0.195 mg/L 3compartmentss NA 50% Human Human +DTXSID7020768 Css NA 2.046 mg/L 3compartmentss NA 95% Human Human +DTXSID7020768 Css NA 0.1156 mg/L PBTK NA 50% Human Human +DTXSID7020768 Css NA 1.184 mg/L PBTK NA 95% Human Human DTXSID7020768 Clint 71 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID7020768 Fup 0.0144 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID7020768 Vd NA 0.1824 L/kg 1compartment NA NA Rat Rat +DTXSID7020768 Vd NA 0.1777 L/kg 1compartment NA NA Rat Rat DTXSID7020768 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID7020768 TK.Half.Life NA 0.555 hours 1compartment NA NA Rat Rat -DTXSID7020768 Css NA 0.4228 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7020768 Css NA 3.689 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7020768 Css NA 0.2302 mg/L PBTK NA 50% Rat Rat -DTXSID7020768 Css NA 1.994 mg/L PBTK NA 95% Rat Rat -DTXSID7020841 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020841 Fup NA 0.1884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020841 Vd NA 0.7677 L/kg 1compartment NA NA Human Human +DTXSID7020768 TK.Half.Life NA 0.5432 hours 1compartment NA NA Rat Rat +DTXSID7020768 Css NA 0.09452 mg/L 3compartmentss NA 50% Rat Rat +DTXSID7020768 Css NA 0.813 mg/L 3compartmentss NA 95% Rat Rat +DTXSID7020768 Css NA 0.05326 mg/L PBTK NA 50% Rat Rat +DTXSID7020768 Css NA 0.4556 mg/L PBTK NA 95% Rat Rat +DTXSID7020841 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020841 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020841 Vd NA 0.8348 L/kg 1compartment NA NA Human Human DTXSID7020841 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7020841 TK.Half.Life NA 26.44 hours 1compartment NA NA Human Human -DTXSID7020841 Css NA 4.02 mg/L 3compartmentss NA 50% Human Human -DTXSID7020841 Css NA 15.05 mg/L 3compartmentss NA 95% Human Human -DTXSID7020841 Css NA 2.799 mg/L PBTK NA 50% Human Human -DTXSID7020841 Css NA 9.388 mg/L PBTK NA 95% Human Human -DTXSID7020841 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020841 Fup NA 0.1884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020841 Vd NA 0.7593 L/kg 1compartment NA NA Rat Human +DTXSID7020841 TK.Half.Life NA 22.64 hours 1compartment NA NA Human Human +DTXSID7020841 Css NA 2.591 mg/L 3compartmentss NA 50% Human Human +DTXSID7020841 Css NA 10.35 mg/L 3compartmentss NA 95% Human Human +DTXSID7020841 Css NA 1.87 mg/L PBTK NA 50% Human Human +DTXSID7020841 Css NA 6.574 mg/L PBTK NA 95% Human Human +DTXSID7020841 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020841 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020841 Vd NA 0.8317 L/kg 1compartment NA NA Rat Human DTXSID7020841 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020841 TK.Half.Life NA 8.89 hours 1compartment NA NA Rat Human -DTXSID7020841 Css NA 1.11 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020841 Css NA 3.456 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020841 Css NA 0.7341 mg/L PBTK NA 50% Rat Human -DTXSID7020841 Css NA 2.019 mg/L PBTK NA 95% Rat Human -DTXSID7020843 Clint NA 13.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020843 Fup NA 0.0119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020843 Vd NA 11.63 L/kg 1compartment NA NA Human Human -DTXSID7020843 Days.Css NA 123 Days PBTK NA NA Human Human -DTXSID7020843 TK.Half.Life NA 539 hours 1compartment NA NA Human Human -DTXSID7020843 Css NA 2.86 mg/L 3compartmentss NA 50% Human Human -DTXSID7020843 Css NA 16.17 mg/L 3compartmentss NA 95% Human Human -DTXSID7020843 Css NA 3.795 mg/L PBTK NA 50% Human Human -DTXSID7020843 Css NA 21.02 mg/L PBTK NA 95% Human Human -DTXSID7020843 Clint NA 13.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020843 Fup NA 0.0119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020843 Vd NA 9.222 L/kg 1compartment NA NA Rat Human -DTXSID7020843 Days.Css NA 73 Days PBTK NA NA Rat Human -DTXSID7020843 TK.Half.Life NA 75.04 hours 1compartment NA NA Rat Human -DTXSID7020843 Css NA 1.548 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020843 Css NA 6.515 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020843 Css NA 2.071 mg/L PBTK NA 50% Rat Human -DTXSID7020843 Css NA 8.586 mg/L PBTK NA 95% Rat Human -DTXSID7020847 Clint NA 4.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020847 Fup NA 0.0675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020847 Vd NA 1.86 L/kg 1compartment NA NA Human Human -DTXSID7020847 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7020847 TK.Half.Life NA 31.27 hours 1compartment NA NA Human Human -DTXSID7020847 Css NA 2.534 mg/L 3compartmentss NA 50% Human Human -DTXSID7020847 Css NA 14.41 mg/L 3compartmentss NA 95% Human Human -DTXSID7020847 Css NA 1.666 mg/L PBTK NA 50% Human Human -DTXSID7020847 Css NA 8.939 mg/L PBTK NA 95% Human Human -DTXSID7020847 Clint NA 4.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020847 Fup NA 0.0675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020847 Vd NA 1.396 L/kg 1compartment NA NA Rat Human -DTXSID7020847 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7020847 TK.Half.Life NA 10.04 hours 1compartment NA NA Rat Human -DTXSID7020847 Css NA 1.299 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020847 Css NA 5.367 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020847 Css NA 0.8076 mg/L PBTK NA 50% Rat Human -DTXSID7020847 Css NA 3.13 mg/L PBTK NA 95% Rat Human -DTXSID7020893 Clint NA 92.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020893 Fup NA 0.1284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020893 Vd NA 1.396 L/kg 1compartment NA NA Human Human +DTXSID7020841 TK.Half.Life NA 7.675 hours 1compartment NA NA Rat Human +DTXSID7020841 Css NA 0.06232 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020841 Css NA 0.3432 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020841 Css NA 0.04467 mg/L PBTK NA 50% Rat Human +DTXSID7020841 Css NA 0.2184 mg/L PBTK NA 95% Rat Human +DTXSID7020847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020847 Fup 0.0361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020847 Vd NA 1.361 L/kg 1compartment NA NA Human Human +DTXSID7020847 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7020847 TK.Half.Life NA 7.947 hours 1compartment NA NA Human Human +DTXSID7020847 Css NA 0.874 mg/L 3compartmentss NA 50% Human Human +DTXSID7020847 Css NA 6.555 mg/L 3compartmentss NA 95% Human Human +DTXSID7020847 Css NA 0.546 mg/L PBTK NA 50% Human Human +DTXSID7020847 Css NA 4.022 mg/L PBTK NA 95% Human Human +DTXSID7020847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020847 Fup 0.0361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020847 Vd NA 1.014 L/kg 1compartment NA NA Rat Human +DTXSID7020847 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7020847 TK.Half.Life NA 3.161 hours 1compartment NA NA Rat Human +DTXSID7020847 Css NA 0.1131 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020847 Css NA 0.676 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020847 Css NA 0.06865 mg/L PBTK NA 50% Rat Human +DTXSID7020847 Css NA 0.3986 mg/L PBTK NA 95% Rat Human +DTXSID7020893 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020893 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020893 Vd NA 1.819 L/kg 1compartment NA NA Human Human DTXSID7020893 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020893 TK.Half.Life NA 1.66 hours 1compartment NA NA Human Human -DTXSID7020893 Css NA 0.05746 mg/L 3compartmentss NA 50% Human Human -DTXSID7020893 Css NA 0.474 mg/L 3compartmentss NA 95% Human Human -DTXSID7020893 Css NA 0.03854 mg/L PBTK NA 50% Human Human -DTXSID7020893 Css NA 0.3003 mg/L PBTK NA 95% Human Human -DTXSID7020893 Clint NA 92.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020893 Fup NA 0.1284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020893 Vd NA 1.081 L/kg 1compartment NA NA Rat Human +DTXSID7020893 TK.Half.Life NA 3.175 hours 1compartment NA NA Human Human +DTXSID7020893 Css NA 0.1188 mg/L 3compartmentss NA 50% Human Human +DTXSID7020893 Css NA 0.8007 mg/L 3compartmentss NA 95% Human Human +DTXSID7020893 Css NA 0.08728 mg/L PBTK NA 50% Human Human +DTXSID7020893 Css NA 0.5521 mg/L PBTK NA 95% Human Human +DTXSID7020893 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020893 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020893 Vd NA 1.418 L/kg 1compartment NA NA Rat Human DTXSID7020893 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020893 TK.Half.Life NA 0.6112 hours 1compartment NA NA Rat Human -DTXSID7020893 Css NA 0.032 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020893 Css NA 0.2068 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020893 Css NA 0.0203 mg/L PBTK NA 50% Rat Human -DTXSID7020893 Css NA 0.1249 mg/L PBTK NA 95% Rat Human -DTXSID7020897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020897 Fup NA 0.0628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020897 Vd NA 2.175 L/kg 1compartment NA NA Human Human -DTXSID7020897 Days.Css NA 60 Days PBTK NA NA Human Human -DTXSID7020897 TK.Half.Life NA 271.8 hours 1compartment NA NA Human Human -DTXSID7020897 Css NA 16.06 mg/L 3compartmentss NA 50% Human Human -DTXSID7020897 Css NA 74.02 mg/L 3compartmentss NA 95% Human Human -DTXSID7020897 Css NA 12.13 mg/L PBTK NA 50% Human Human -DTXSID7020897 Css NA 46.75 mg/L PBTK NA 95% Human Human -DTXSID7020897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020897 Fup NA 0.0628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020897 Vd NA 1.99 L/kg 1compartment NA NA Rat Human -DTXSID7020897 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID7020897 TK.Half.Life NA 73.41 hours 1compartment NA NA Rat Human -DTXSID7020897 Css NA 4.432 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020897 Css NA 17.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020897 Css NA 3.194 mg/L PBTK NA 50% Rat Human -DTXSID7020897 Css NA 10.27 mg/L PBTK NA 95% Rat Human -DTXSID7020899 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020899 Fup NA 0.8641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020899 Vd NA 3.138 L/kg 1compartment NA NA Human Human -DTXSID7020899 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID7020899 TK.Half.Life NA 102600 hours 1compartment NA NA Human Human -DTXSID7020899 Css NA 3678 mg/L 3compartmentss NA 50% Human Human -DTXSID7020899 Css NA 9329 mg/L 3compartmentss NA 95% Human Human -DTXSID7020899 Css NA 2566 mg/L PBTK NA 50% Human Human -DTXSID7020899 Css NA 6073 mg/L PBTK NA 95% Human Human -DTXSID7020899 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020899 Fup NA 0.8641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020899 Vd NA 2.352 L/kg 1compartment NA NA Rat Human -DTXSID7020899 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID7020899 TK.Half.Life NA 6250 hours 1compartment NA NA Rat Human -DTXSID7020899 Css NA 1006 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020899 Css NA 2193 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020899 Css NA 671.1 mg/L PBTK NA 50% Rat Human -DTXSID7020899 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID7020920 Clint NA 4.687 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020920 Fup NA 0.1703 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020920 Vd NA 1.268 L/kg 1compartment NA NA Human Human +DTXSID7020893 TK.Half.Life NA 1.146 hours 1compartment NA NA Rat Human +DTXSID7020893 Css NA 0.01494 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020893 Css NA 0.07676 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020893 Css NA 0.01092 mg/L PBTK NA 50% Rat Human +DTXSID7020893 Css NA 0.05358 mg/L PBTK NA 95% Rat Human +DTXSID7020897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020897 Fup 0.0547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020897 Vd NA 1.944 L/kg 1compartment NA NA Human Human +DTXSID7020897 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7020897 TK.Half.Life NA 5.899 hours 1compartment NA NA Human Human +DTXSID7020897 Css NA 0.3397 mg/L 3compartmentss NA 50% Human Human +DTXSID7020897 Css NA 2.873 mg/L 3compartmentss NA 95% Human Human +DTXSID7020897 Css NA 0.2462 mg/L PBTK NA 50% Human Human +DTXSID7020897 Css NA 1.884 mg/L PBTK NA 95% Human Human +DTXSID7020897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020897 Fup 0.0547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020897 Vd NA 1.782 L/kg 1compartment NA NA Rat Human +DTXSID7020897 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7020897 TK.Half.Life NA 3.085 hours 1compartment NA NA Rat Human +DTXSID7020897 Css NA 0.04338 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020897 Css NA 0.3033 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020897 Css NA 0.0311 mg/L PBTK NA 50% Rat Human +DTXSID7020897 Css NA 0.1999 mg/L PBTK NA 95% Rat Human +DTXSID7020920 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020920 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020920 Vd NA 1.131 L/kg 1compartment NA NA Human Human DTXSID7020920 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020920 TK.Half.Life NA 6.97 hours 1compartment NA NA Human Human -DTXSID7020920 Css NA 0.6067 mg/L 3compartmentss NA 50% Human Human -DTXSID7020920 Css NA 3.238 mg/L 3compartmentss NA 95% Human Human -DTXSID7020920 Css NA 0.4243 mg/L PBTK NA 50% Human Human -DTXSID7020920 Css NA 2.091 mg/L PBTK NA 95% Human Human -DTXSID7020920 Clint NA 4.687 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020920 Fup NA 0.1703 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020920 Vd NA 1.007 L/kg 1compartment NA NA Rat Human +DTXSID7020920 TK.Half.Life NA 2.448 hours 1compartment NA NA Human Human +DTXSID7020920 Css NA 0.1968 mg/L 3compartmentss NA 50% Human Human +DTXSID7020920 Css NA 1.633 mg/L 3compartmentss NA 95% Human Human +DTXSID7020920 Css NA 0.1319 mg/L PBTK NA 50% Human Human +DTXSID7020920 Css NA 1.029 mg/L PBTK NA 95% Human Human +DTXSID7020920 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020920 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020920 Vd NA 0.8959 L/kg 1compartment NA NA Rat Human DTXSID7020920 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020920 TK.Half.Life NA 2.891 hours 1compartment NA NA Rat Human -DTXSID7020920 Css NA 0.3035 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020920 Css NA 1.145 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020920 Css NA 0.2036 mg/L PBTK NA 50% Rat Human -DTXSID7020920 Css NA 0.698 mg/L PBTK NA 95% Rat Human -DTXSID7020922 Clint NA 2.494 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020922 Fup NA 0.1247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020922 Vd NA 0.2214 L/kg 1compartment NA NA Human Human +DTXSID7020920 TK.Half.Life NA 1.04 hours 1compartment NA NA Rat Human +DTXSID7020920 Css NA 0.02602 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020920 Css NA 0.1547 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020920 Css NA 0.01702 mg/L PBTK NA 50% Rat Human +DTXSID7020920 Css NA 0.09504 mg/L PBTK NA 95% Rat Human +DTXSID7020922 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020922 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020922 Vd NA 0.2578 L/kg 1compartment NA NA Human Human DTXSID7020922 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020922 TK.Half.Life NA 2.079 hours 1compartment NA NA Human Human -DTXSID7020922 Css NA 1.455 mg/L 3compartmentss NA 50% Human Human -DTXSID7020922 Css NA 8.952 mg/L 3compartmentss NA 95% Human Human -DTXSID7020922 Css NA 0.8858 mg/L PBTK NA 50% Human Human -DTXSID7020922 Css NA 5.25 mg/L PBTK NA 95% Human Human -DTXSID7020922 Clint NA 2.494 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020922 Fup NA 0.1247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020922 Vd NA 0.2263 L/kg 1compartment NA NA Rat Human +DTXSID7020922 TK.Half.Life NA 0.79 hours 1compartment NA NA Human Human +DTXSID7020922 Css NA 0.3021 mg/L 3compartmentss NA 50% Human Human +DTXSID7020922 Css NA 1.899 mg/L 3compartmentss NA 95% Human Human +DTXSID7020922 Css NA 0.1902 mg/L PBTK NA 50% Human Human +DTXSID7020922 Css NA 1.152 mg/L PBTK NA 95% Human Human +DTXSID7020922 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020922 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020922 Vd NA 0.2662 L/kg 1compartment NA NA Rat Human DTXSID7020922 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020922 TK.Half.Life NA 1.226 hours 1compartment NA NA Rat Human -DTXSID7020922 Css NA 0.7184 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020922 Css NA 3.157 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020922 Css NA 0.4075 mg/L PBTK NA 50% Rat Human -DTXSID7020922 Css NA 1.728 mg/L PBTK NA 95% Rat Human -DTXSID7020928 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020928 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020928 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID7020928 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7020928 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID7020928 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID7020928 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID7020928 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID7020928 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID7020928 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020928 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020928 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human -DTXSID7020928 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020928 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID7020928 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020928 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020928 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID7020928 Css NA 1.296 mg/L PBTK NA 95% Rat Human +DTXSID7020922 TK.Half.Life NA 0.4751 hours 1compartment NA NA Rat Human +DTXSID7020922 Css NA 0.03703 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020922 Css NA 0.1606 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020922 Css NA 0.02286 mg/L PBTK NA 50% Rat Human +DTXSID7020922 Css NA 0.09558 mg/L PBTK NA 95% Rat Human +DTXSID7020970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020970 Fup 0.00637 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020970 Vd NA 2.353 L/kg 1compartment NA NA Human Human +DTXSID7020970 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID7020970 TK.Half.Life NA 49.06 hours 1compartment NA NA Human Human +DTXSID7020970 Css NA 3.133 mg/L 3compartmentss NA 50% Human Human +DTXSID7020970 Css NA 24.15 mg/L 3compartmentss NA 95% Human Human +DTXSID7020970 Css NA 2.026 mg/L PBTK NA 50% Human Human +DTXSID7020970 Css NA 14.93 mg/L PBTK NA 95% Human Human +DTXSID7020970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020970 Fup 0.00637 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020970 Vd NA 1.748 L/kg 1compartment NA NA Rat Human +DTXSID7020970 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7020970 TK.Half.Life NA 13.1 hours 1compartment NA NA Rat Human +DTXSID7020970 Css NA 0.3998 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020970 Css NA 2.671 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020970 Css NA 0.2552 mg/L PBTK NA 50% Rat Human +DTXSID7020970 Css NA 1.644 mg/L PBTK NA 95% Rat Human DTXSID7020972 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7020972 Fup 0.415 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7020972 Vd NA 0.4858 L/kg 1compartment NA NA Human Human DTXSID7020972 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7020972 TK.Half.Life NA 7.574 hours 1compartment NA NA Human Human -DTXSID7020972 Css NA 1.608 mg/L 3compartmentss NA 50% Human Human -DTXSID7020972 Css NA 5.519 mg/L 3compartmentss NA 95% Human Human -DTXSID7020972 Css NA 1.245 mg/L PBTK NA 50% Human Human -DTXSID7020972 Css NA 3.698 mg/L PBTK NA 95% Human Human +DTXSID7020972 Css NA 1.453 mg/L 3compartmentss NA 50% Human Human +DTXSID7020972 Css NA 4.347 mg/L 3compartmentss NA 95% Human Human +DTXSID7020972 Css NA 1.104 mg/L PBTK NA 50% Human Human +DTXSID7020972 Css NA 3.304 mg/L PBTK NA 95% Human Human DTXSID7020972 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7020972 Fup 0.415 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7020972 Vd NA 0.5047 L/kg 1compartment NA NA Rat Human DTXSID7020972 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7020972 TK.Half.Life NA 2.68 hours 1compartment NA NA Rat Human -DTXSID7020972 Css NA 0.437 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020972 Css NA 1.257 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020972 Css NA 0.3256 mg/L PBTK NA 50% Rat Human -DTXSID7020972 Css NA 0.7856 mg/L PBTK NA 95% Rat Human -DTXSID7020978 Clint NA 8.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020978 Fup NA 0.1088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7020978 Vd NA 2.193 L/kg 1compartment NA NA Human Human -DTXSID7020978 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7020978 TK.Half.Life NA 15.75 hours 1compartment NA NA Human Human -DTXSID7020978 Css NA 0.9273 mg/L 3compartmentss NA 50% Human Human -DTXSID7020978 Css NA 5.619 mg/L 3compartmentss NA 95% Human Human -DTXSID7020978 Css NA 0.6337 mg/L PBTK NA 50% Human Human -DTXSID7020978 Css NA 3.626 mg/L PBTK NA 95% Human Human -DTXSID7020978 Clint NA 8.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020978 Fup NA 0.1088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7020978 Vd NA 1.66 L/kg 1compartment NA NA Rat Human +DTXSID7020972 Css NA 0.03856 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020972 Css NA 0.1485 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020972 Css NA 0.02976 mg/L PBTK NA 50% Rat Human +DTXSID7020972 Css NA 0.1161 mg/L PBTK NA 95% Rat Human +DTXSID7020978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020978 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7020978 Vd NA 2.709 L/kg 1compartment NA NA Human Human +DTXSID7020978 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7020978 TK.Half.Life NA 12.45 hours 1compartment NA NA Human Human +DTXSID7020978 Css NA 0.4972 mg/L 3compartmentss NA 50% Human Human +DTXSID7020978 Css NA 3.237 mg/L 3compartmentss NA 95% Human Human +DTXSID7020978 Css NA 0.3463 mg/L PBTK NA 50% Human Human +DTXSID7020978 Css NA 2.154 mg/L PBTK NA 95% Human Human +DTXSID7020978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020978 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7020978 Vd NA 2.044 L/kg 1compartment NA NA Rat Human DTXSID7020978 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7020978 TK.Half.Life NA 4.68 hours 1compartment NA NA Rat Human -DTXSID7020978 Css NA 0.4971 mg/L 3compartmentss NA 50% Rat Human -DTXSID7020978 Css NA 2.206 mg/L 3compartmentss NA 95% Rat Human -DTXSID7020978 Css NA 0.3246 mg/L PBTK NA 50% Rat Human -DTXSID7020978 Css NA 1.366 mg/L PBTK NA 95% Rat Human +DTXSID7020978 TK.Half.Life NA 2.882 hours 1compartment NA NA Rat Human +DTXSID7020978 Css NA 0.06319 mg/L 3compartmentss NA 50% Rat Human +DTXSID7020978 Css NA 0.3261 mg/L 3compartmentss NA 95% Rat Human +DTXSID7020978 Css NA 0.0437 mg/L PBTK NA 50% Rat Human +DTXSID7020978 Css NA 0.2208 mg/L PBTK NA 95% Rat Human +DTXSID70209826 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID70209826 Fup 0.274 NA NA Williamson 2020 NA Human Human +DTXSID70209826 Vd NA 1.489 L/kg 1compartment NA NA Human Human +DTXSID70209826 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70209826 TK.Half.Life NA 6.365 hours 1compartment NA NA Human Human +DTXSID70209826 Css NA 0.3639 mg/L 3compartmentss NA 50% Human Human +DTXSID70209826 Css NA 1.984 mg/L 3compartmentss NA 95% Human Human +DTXSID70209826 Css NA 0.2718 mg/L PBTK NA 50% Human Human +DTXSID70209826 Css NA 1.339 mg/L PBTK NA 95% Human Human +DTXSID70209826 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID70209826 Fup 0.274 NA NA Williamson 2020 NA Rat Human +DTXSID70209826 Vd NA 1.198 L/kg 1compartment NA NA Rat Human +DTXSID70209826 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70209826 TK.Half.Life NA 2.52 hours 1compartment NA NA Rat Human +DTXSID70209826 Css NA 0.01178 mg/L 3compartmentss NA 50% Rat Human +DTXSID70209826 Css NA 0.07669 mg/L 3compartmentss NA 95% Rat Human +DTXSID70209826 Css NA 0.008574 mg/L PBTK NA 50% Rat Human +DTXSID70209826 Css NA 0.05134 mg/L PBTK NA 95% Rat Human DTXSID7021027 Clint NA 0.01338 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021027 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021027 Vd NA 0.6966 L/kg 1compartment NA NA Human Human +DTXSID7021027 Vd NA 0.7806 L/kg 1compartment NA NA Human Human DTXSID7021027 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021027 TK.Half.Life NA 4.407 hours 1compartment NA NA Human Human -DTXSID7021027 Css NA 0.8256 mg/L 3compartmentss NA 50% Human Human -DTXSID7021027 Css NA 5.469 mg/L 3compartmentss NA 95% Human Human -DTXSID7021027 Css NA 0.6772 mg/L PBTK NA 50% Human Human -DTXSID7021027 Css NA 3.591 mg/L PBTK NA 95% Human Human +DTXSID7021027 TK.Half.Life NA 4.94 hours 1compartment NA NA Human Human +DTXSID7021027 Css NA 0.681 mg/L 3compartmentss NA 50% Human Human +DTXSID7021027 Css NA 4.414 mg/L 3compartmentss NA 95% Human Human +DTXSID7021027 Css NA 0.5748 mg/L PBTK NA 50% Human Human +DTXSID7021027 Css NA 2.924 mg/L PBTK NA 95% Human Human DTXSID7021027 Clint NA 0.01338 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021027 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021027 Vd NA 0.7478 L/kg 1compartment NA NA Rat Human +DTXSID7021027 Vd NA 0.8186 L/kg 1compartment NA NA Rat Human DTXSID7021027 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021027 TK.Half.Life NA 1.631 hours 1compartment NA NA Rat Human -DTXSID7021027 Css NA 0.2124 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021027 Css NA 1.311 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021027 Css NA 0.171 mg/L PBTK NA 50% Rat Human -DTXSID7021027 Css NA 0.7847 mg/L PBTK NA 95% Rat Human +DTXSID7021027 TK.Half.Life NA 1.786 hours 1compartment NA NA Rat Human +DTXSID7021027 Css NA 0.01248 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021027 Css NA 0.1018 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021027 Css NA 0.01024 mg/L PBTK NA 50% Rat Human +DTXSID7021027 Css NA 0.06748 mg/L PBTK NA 95% Rat Human +DTXSID7021029 Clint NA 0.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7021029 Fup NA 0.8692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7021029 Vd NA 0.7759 L/kg 1compartment NA NA Human Human +DTXSID7021029 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7021029 TK.Half.Life NA 5.654 hours 1compartment NA NA Human Human +DTXSID7021029 Css NA 0.7787 mg/L 3compartmentss NA 50% Human Human +DTXSID7021029 Css NA 4.644 mg/L 3compartmentss NA 95% Human Human +DTXSID7021029 Css NA 0.6481 mg/L PBTK NA 50% Human Human +DTXSID7021029 Css NA 2.982 mg/L PBTK NA 95% Human Human +DTXSID7021029 Clint NA 0.014 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7021029 Fup NA 0.8692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7021029 Vd NA 0.8023 L/kg 1compartment NA NA Rat Human +DTXSID7021029 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7021029 TK.Half.Life NA 2.013 hours 1compartment NA NA Rat Human +DTXSID7021029 Css NA 0.01491 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021029 Css NA 0.1069 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021029 Css NA 0.01186 mg/L PBTK NA 50% Rat Human +DTXSID7021029 Css NA 0.07161 mg/L PBTK NA 95% Rat Human +DTXSID7021073 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021073 Fup 2e-04 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human +DTXSID7021073 Vd NA 0.1653 L/kg 1compartment NA NA Human Human +DTXSID7021073 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID7021073 TK.Half.Life NA 133.7 hours 1compartment NA NA Human Human +DTXSID7021073 Css NA 119.9 mg/L 3compartmentss NA 50% Human Human +DTXSID7021073 Css NA 697.5 mg/L 3compartmentss NA 95% Human Human +DTXSID7021073 Css NA 69.19 mg/L PBTK NA 50% Human Human +DTXSID7021073 Css NA 402.7 mg/L PBTK NA 95% Human Human +DTXSID7021073 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021073 Fup 2e-04 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human +DTXSID7021073 Vd NA 0.1612 L/kg 1compartment NA NA Rat Human +DTXSID7021073 Days.Css NA 19 Days PBTK NA NA Rat Human +DTXSID7021073 TK.Half.Life NA 89.1 hours 1compartment NA NA Rat Human +DTXSID7021073 Css NA 5.828 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021073 Css NA 34.3 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021073 Css NA 3.418 mg/L PBTK NA 50% Rat Human +DTXSID7021073 Css NA 20.42 mg/L PBTK NA 95% Rat Human DTXSID7021100 Clint 6.65 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7021100 Fup 0.04 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID7021100 Vd NA 1.229 L/kg 1compartment NA NA Human Human DTXSID7021100 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID7021100 TK.Half.Life NA 17.77 hours 1compartment NA NA Human Human -DTXSID7021100 Css NA 2.165 mg/L 3compartmentss NA 50% Human Human -DTXSID7021100 Css NA 17.92 mg/L 3compartmentss NA 95% Human Human -DTXSID7021100 Css NA 1.532 mg/L PBTK NA 50% Human Human -DTXSID7021100 Css NA 11.43 mg/L PBTK NA 95% Human Human +DTXSID7021100 Css NA 1.971 mg/L 3compartmentss NA 50% Human Human +DTXSID7021100 Css NA 14.71 mg/L 3compartmentss NA 95% Human Human +DTXSID7021100 Css NA 1.485 mg/L PBTK NA 50% Human Human +DTXSID7021100 Css NA 11.08 mg/L PBTK NA 95% Human Human DTXSID7021100 Clint 6.65 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7021100 Fup 0.04 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID7021100 Vd NA 0.9199 L/kg 1compartment NA NA Rat Human DTXSID7021100 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7021100 TK.Half.Life NA 7.201 hours 1compartment NA NA Rat Human -DTXSID7021100 Css NA 1.16 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021100 Css NA 7.343 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021100 Css NA 0.768 mg/L PBTK NA 50% Rat Human -DTXSID7021100 Css NA 4.256 mg/L PBTK NA 95% Rat Human -DTXSID7021102 Clint NA 0.853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021102 Fup NA 0.1556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021102 Vd NA 0.3491 L/kg 1compartment NA NA Human Human +DTXSID7021100 Css NA 0.232 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021100 Css NA 1.328 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021100 Css NA 0.181 mg/L PBTK NA 50% Rat Human +DTXSID7021100 Css NA 1.036 mg/L PBTK NA 95% Rat Human +DTXSID7021102 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021102 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021102 Vd NA 0.4272 L/kg 1compartment NA NA Human Human DTXSID7021102 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021102 TK.Half.Life NA 6.118 hours 1compartment NA NA Human Human -DTXSID7021102 Css NA 2.42 mg/L 3compartmentss NA 50% Human Human -DTXSID7021102 Css NA 12.05 mg/L 3compartmentss NA 95% Human Human -DTXSID7021102 Css NA 1.558 mg/L PBTK NA 50% Human Human -DTXSID7021102 Css NA 7.195 mg/L PBTK NA 95% Human Human -DTXSID7021102 Clint NA 0.853 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021102 Fup NA 0.1556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021102 Vd NA 0.3369 L/kg 1compartment NA NA Rat Human +DTXSID7021102 TK.Half.Life NA 1.139 hours 1compartment NA NA Human Human +DTXSID7021102 Css NA 0.2116 mg/L 3compartmentss NA 50% Human Human +DTXSID7021102 Css NA 1.298 mg/L 3compartmentss NA 95% Human Human +DTXSID7021102 Css NA 0.1454 mg/L PBTK NA 50% Human Human +DTXSID7021102 Css NA 0.8435 mg/L PBTK NA 95% Human Human +DTXSID7021102 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021102 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021102 Vd NA 0.4186 L/kg 1compartment NA NA Rat Human DTXSID7021102 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021102 TK.Half.Life NA 2.85 hours 1compartment NA NA Rat Human -DTXSID7021102 Css NA 0.9794 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021102 Css NA 3.959 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021102 Css NA 0.5905 mg/L PBTK NA 50% Rat Human -DTXSID7021102 Css NA 2.211 mg/L PBTK NA 95% Rat Human +DTXSID7021102 TK.Half.Life NA 0.6388 hours 1compartment NA NA Rat Human +DTXSID7021102 Css NA 0.009307 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021102 Css NA 0.06661 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021102 Css NA 0.006304 mg/L PBTK NA 50% Rat Human +DTXSID7021102 Css NA 0.04144 mg/L PBTK NA 95% Rat Human +DTXSID70211040 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70211040 Fup 0.054 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70211040 Vd NA 0.9431 L/kg 1compartment NA NA Human Human +DTXSID70211040 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70211040 TK.Half.Life NA 3.851 hours 1compartment NA NA Human Human +DTXSID70211040 Css NA 0.5384 mg/L 3compartmentss NA 50% Human Human +DTXSID70211040 Css NA 4.451 mg/L 3compartmentss NA 95% Human Human +DTXSID70211040 Css NA 0.3362 mg/L PBTK NA 50% Human Human +DTXSID70211040 Css NA 2.663 mg/L PBTK NA 95% Human Human +DTXSID70211040 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70211040 Fup 0.054 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70211040 Vd NA 0.7249 L/kg 1compartment NA NA Rat Human +DTXSID70211040 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70211040 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human +DTXSID70211040 Css NA 0.0712 mg/L 3compartmentss NA 50% Rat Human +DTXSID70211040 Css NA 0.4558 mg/L 3compartmentss NA 95% Rat Human +DTXSID70211040 Css NA 0.04322 mg/L PBTK NA 50% Rat Human +DTXSID70211040 Css NA 0.2659 mg/L PBTK NA 95% Rat Human DTXSID7021106 Clint 8.764 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7021106 Fup 0.05441 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7021106 Vd NA 4.68 L/kg 1compartment NA NA Human Human DTXSID7021106 Days.Css NA 27 Days PBTK NA NA Human Human DTXSID7021106 TK.Half.Life NA 153.7 hours 1compartment NA NA Human Human -DTXSID7021106 Css NA 4.863 mg/L 3compartmentss NA 50% Human Human -DTXSID7021106 Css NA 27.63 mg/L 3compartmentss NA 95% Human Human -DTXSID7021106 Css NA 2.856 mg/L PBTK NA 50% Human Human -DTXSID7021106 Css NA 16.35 mg/L PBTK NA 95% Human Human +DTXSID7021106 Css NA 4.074 mg/L 3compartmentss NA 50% Human Human +DTXSID7021106 Css NA 23.41 mg/L 3compartmentss NA 95% Human Human +DTXSID7021106 Css NA 2.804 mg/L PBTK NA 50% Human Human +DTXSID7021106 Css NA 16.11 mg/L PBTK NA 95% Human Human DTXSID7021106 Clint 3.5 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID7021106 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID7021106 Css NA 11.82 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7021106 Css NA 63.67 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7021150 Clint NA 7.332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021150 Fup NA 0.1322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021150 Vd NA 2.187 L/kg 1compartment NA NA Human Human -DTXSID7021150 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7021150 TK.Half.Life NA 15.17 hours 1compartment NA NA Human Human -DTXSID7021150 Css NA 0.8662 mg/L 3compartmentss NA 50% Human Human -DTXSID7021150 Css NA 5.266 mg/L 3compartmentss NA 95% Human Human -DTXSID7021150 Css NA 0.6 mg/L PBTK NA 50% Human Human -DTXSID7021150 Css NA 3.447 mg/L PBTK NA 95% Human Human -DTXSID7021150 Clint NA 7.332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021150 Fup NA 0.1322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021150 Vd NA 1.661 L/kg 1compartment NA NA Rat Human -DTXSID7021150 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021150 TK.Half.Life NA 4.522 hours 1compartment NA NA Rat Human -DTXSID7021150 Css NA 0.4638 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021150 Css NA 2.017 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021150 Css NA 0.306 mg/L PBTK NA 50% Rat Human -DTXSID7021150 Css NA 1.24 mg/L PBTK NA 95% Rat Human -DTXSID7021152 Clint NA 11.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021152 Fup NA 0.0584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021152 Vd NA 1.811 L/kg 1compartment NA NA Human Human -DTXSID7021152 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7021152 TK.Half.Life NA 14.37 hours 1compartment NA NA Human Human -DTXSID7021152 Css NA 1.132 mg/L 3compartmentss NA 50% Human Human -DTXSID7021152 Css NA 7.605 mg/L 3compartmentss NA 95% Human Human -DTXSID7021152 Css NA 0.7422 mg/L PBTK NA 50% Human Human -DTXSID7021152 Css NA 4.679 mg/L PBTK NA 95% Human Human -DTXSID7021152 Clint NA 11.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021152 Fup NA 0.0584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021152 Vd NA 1.361 L/kg 1compartment NA NA Rat Human -DTXSID7021152 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021152 TK.Half.Life NA 4.987 hours 1compartment NA NA Rat Human -DTXSID7021152 Css NA 0.6232 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021152 Css NA 3.125 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021152 Css NA 0.3846 mg/L PBTK NA 50% Rat Human -DTXSID7021152 Css NA 1.846 mg/L PBTK NA 95% Rat Human -DTXSID7021156 Clint NA 1018 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021156 Fup NA 0.3286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021156 Vd NA 0.8196 L/kg 1compartment NA NA Human Human -DTXSID7021156 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021156 TK.Half.Life NA 0.6075 hours 1compartment NA NA Human Human -DTXSID7021156 Css NA 0.001395 mg/L 3compartmentss NA 50% Human Human -DTXSID7021156 Css NA 0.01098 mg/L 3compartmentss NA 95% Human Human -DTXSID7021156 Css NA 0.001035 mg/L PBTK NA 50% Human Human -DTXSID7021156 Css NA 0.007547 mg/L PBTK NA 95% Human Human -DTXSID7021156 Clint NA 1018 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021156 Fup NA 0.3286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021156 Vd NA 0.7948 L/kg 1compartment NA NA Rat Human +DTXSID7021106 Css 2.8 2.278 mg/L 3compartmentss National Toxicology Program 50% Rat Rat +DTXSID7021106 Css 2.8 11.74 mg/L 3compartmentss National Toxicology Program 95% Rat Rat +DTXSID70211363 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70211363 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70211363 Vd NA 3.095 L/kg 1compartment NA NA Human Human +DTXSID70211363 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID70211363 TK.Half.Life NA 84.43 hours 1compartment NA NA Human Human +DTXSID70211363 Css NA 1.792 mg/L 3compartmentss NA 50% Human Human +DTXSID70211363 Css NA 12.38 mg/L 3compartmentss NA 95% Human Human +DTXSID70211363 Css NA 1.234 mg/L PBTK NA 50% Human Human +DTXSID70211363 Css NA 8.38 mg/L PBTK NA 95% Human Human +DTXSID70211363 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70211363 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70211363 Vd NA 2.318 L/kg 1compartment NA NA Rat Human +DTXSID70211363 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID70211363 TK.Half.Life NA 11.79 hours 1compartment NA NA Rat Human +DTXSID70211363 Css NA 0.01949 mg/L 3compartmentss NA 50% Rat Human +DTXSID70211363 Css NA 0.1247 mg/L 3compartmentss NA 95% Rat Human +DTXSID70211363 Css NA 0.01294 mg/L PBTK NA 50% Rat Human +DTXSID70211363 Css NA 0.08117 mg/L PBTK NA 95% Rat Human +DTXSID7021156 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021156 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021156 Vd NA 1.155 L/kg 1compartment NA NA Human Human +DTXSID7021156 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7021156 TK.Half.Life NA 13.29 hours 1compartment NA NA Human Human +DTXSID7021156 Css NA 1.17 mg/L 3compartmentss NA 50% Human Human +DTXSID7021156 Css NA 8.571 mg/L 3compartmentss NA 95% Human Human +DTXSID7021156 Css NA 1.001 mg/L PBTK NA 50% Human Human +DTXSID7021156 Css NA 5.514 mg/L PBTK NA 95% Human Human +DTXSID7021156 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021156 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021156 Vd NA 1.127 L/kg 1compartment NA NA Rat Human DTXSID7021156 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021156 TK.Half.Life NA 0.2577 hours 1compartment NA NA Rat Human -DTXSID7021156 Css NA 0.0007749 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021156 Css NA 0.005021 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021156 Css NA 0.0005502 mg/L PBTK NA 50% Rat Human -DTXSID7021156 Css NA 0.003301 mg/L PBTK NA 95% Rat Human -DTXSID7021158 Clint NA 0.1067 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021158 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021158 Vd NA 0.7345 L/kg 1compartment NA NA Human Human +DTXSID7021156 TK.Half.Life NA 4.346 hours 1compartment NA NA Rat Human +DTXSID7021156 Css NA 0.07166 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021156 Css NA 0.4746 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021156 Css NA 0.06126 mg/L PBTK NA 50% Rat Human +DTXSID7021156 Css NA 0.2948 mg/L PBTK NA 95% Rat Human +DTXSID7021158 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021158 Fup 0.419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021158 Vd NA 0.4491 L/kg 1compartment NA NA Human Human DTXSID7021158 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021158 TK.Half.Life NA 4.042 hours 1compartment NA NA Human Human -DTXSID7021158 Css NA 0.6966 mg/L 3compartmentss NA 50% Human Human -DTXSID7021158 Css NA 4.617 mg/L 3compartmentss NA 95% Human Human -DTXSID7021158 Css NA 0.58 mg/L PBTK NA 50% Human Human -DTXSID7021158 Css NA 2.985 mg/L PBTK NA 95% Human Human -DTXSID7021158 Clint NA 0.1067 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021158 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021158 Vd NA 0.7788 L/kg 1compartment NA NA Rat Human +DTXSID7021158 TK.Half.Life NA 6.934 hours 1compartment NA NA Human Human +DTXSID7021158 Css NA 1.733 mg/L 3compartmentss NA 50% Human Human +DTXSID7021158 Css NA 7.533 mg/L 3compartmentss NA 95% Human Human +DTXSID7021158 Css NA 1.244 mg/L PBTK NA 50% Human Human +DTXSID7021158 Css NA 4.721 mg/L PBTK NA 95% Human Human +DTXSID7021158 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021158 Fup 0.419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021158 Vd NA 0.4733 L/kg 1compartment NA NA Rat Human DTXSID7021158 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021158 TK.Half.Life NA 1.581 hours 1compartment NA NA Rat Human -DTXSID7021158 Css NA 0.1948 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021158 Css NA 1.218 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021158 Css NA 0.1588 mg/L PBTK NA 50% Rat Human -DTXSID7021158 Css NA 0.7291 mg/L PBTK NA 95% Rat Human -DTXSID7021231 Clint NA 94.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021231 Fup NA 0.0094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021231 Vd NA 0.2181 L/kg 1compartment NA NA Human Human +DTXSID7021158 TK.Half.Life NA 2.491 hours 1compartment NA NA Rat Human +DTXSID7021158 Css NA 0.1106 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021158 Css NA 0.4173 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021158 Css NA 0.07811 mg/L PBTK NA 50% Rat Human +DTXSID7021158 Css NA 0.2525 mg/L PBTK NA 95% Rat Human +DTXSID7021231 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021231 Fup 0.0526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021231 Vd NA 0.1869 L/kg 1compartment NA NA Human Human DTXSID7021231 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021231 TK.Half.Life NA 1.135 hours 1compartment NA NA Human Human -DTXSID7021231 Css NA 0.8294 mg/L 3compartmentss NA 50% Human Human -DTXSID7021231 Css NA 8.623 mg/L 3compartmentss NA 95% Human Human -DTXSID7021231 Css NA 0.4855 mg/L PBTK NA 50% Human Human -DTXSID7021231 Css NA 4.989 mg/L PBTK NA 95% Human Human -DTXSID7021231 Clint NA 94.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021231 Fup NA 0.0094 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021231 Vd NA 0.199 L/kg 1compartment NA NA Rat Human +DTXSID7021231 TK.Half.Life NA 0.7766 hours 1compartment NA NA Human Human +DTXSID7021231 Css NA 0.313 mg/L 3compartmentss NA 50% Human Human +DTXSID7021231 Css NA 2.911 mg/L 3compartmentss NA 95% Human Human +DTXSID7021231 Css NA 0.1852 mg/L PBTK NA 50% Human Human +DTXSID7021231 Css NA 1.672 mg/L PBTK NA 95% Human Human +DTXSID7021231 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021231 Fup 0.0526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021231 Vd NA 0.1876 L/kg 1compartment NA NA Rat Human DTXSID7021231 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021231 TK.Half.Life NA 0.6704 hours 1compartment NA NA Rat Human -DTXSID7021231 Css NA 0.4802 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021231 Css NA 4.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021231 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID7021231 Css NA 2.21 mg/L PBTK NA 95% Rat Human +DTXSID7021231 TK.Half.Life NA 0.4864 hours 1compartment NA NA Rat Human +DTXSID7021231 Css NA 0.003418 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021231 Css NA 0.02684 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021231 Css NA 0.001886 mg/L PBTK NA 50% Rat Human +DTXSID7021231 Css NA 0.01478 mg/L PBTK NA 95% Rat Human DTXSID7021233 Clint NA 0.9503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021233 Fup NA 0.0031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021233 Vd NA 0.4351 L/kg 1compartment NA NA Human Human -DTXSID7021233 Days.Css NA 76 Days PBTK NA NA Human Human -DTXSID7021233 TK.Half.Life NA 309.6 hours 1compartment NA NA Human Human -DTXSID7021233 Css NA 125.5 mg/L 3compartmentss NA 50% Human Human -DTXSID7021233 Css NA 668.4 mg/L 3compartmentss NA 95% Human Human -DTXSID7021233 Css NA 75.15 mg/L PBTK NA 50% Human Human -DTXSID7021233 Css NA 392.4 mg/L PBTK NA 95% Human Human +DTXSID7021233 Vd NA 3.194 L/kg 1compartment NA NA Human Human +DTXSID7021233 Days.Css NA 579 Days PBTK NA NA Human Human +DTXSID7021233 TK.Half.Life NA 2192 hours 1compartment NA NA Human Human +DTXSID7021233 Css NA 70.28 mg/L 3compartmentss NA 50% Human Human +DTXSID7021233 Css NA 370.9 mg/L 3compartmentss NA 95% Human Human +DTXSID7021233 Css NA 48.79 mg/L PBTK NA 50% Human Human +DTXSID7021233 Css NA 261.2 mg/L PBTK NA 95% Human Human DTXSID7021233 Clint NA 0.9503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021233 Fup NA 0.0031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021233 Vd NA 0.356 L/kg 1compartment NA NA Rat Human -DTXSID7021233 Days.Css NA 29 Days PBTK NA NA Rat Human -DTXSID7021233 TK.Half.Life NA 129.2 hours 1compartment NA NA Rat Human -DTXSID7021233 Css NA 54.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021233 Css NA 236.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021233 Css NA 30.32 mg/L PBTK NA 50% Rat Human -DTXSID7021233 Css NA 129 mg/L PBTK NA 95% Rat Human +DTXSID7021233 Vd NA 2.394 L/kg 1compartment NA NA Rat Human +DTXSID7021233 Days.Css NA 304 Days PBTK NA NA Rat Human +DTXSID7021233 TK.Half.Life NA 308.3 hours 1compartment NA NA Rat Human +DTXSID7021233 Css NA 2.553 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021233 Css NA 15.72 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021233 Css NA 1.732 mg/L PBTK NA 50% Rat Human +DTXSID7021233 Css NA 10.5 mg/L PBTK NA 95% Rat Human DTXSID7021235 Clint NA 7.952 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021235 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021235 Vd NA 0.2637 L/kg 1compartment NA NA Human Human +DTXSID7021235 Vd NA 0.218 L/kg 1compartment NA NA Human Human DTXSID7021235 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021235 TK.Half.Life NA 2.246 hours 1compartment NA NA Human Human -DTXSID7021235 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human -DTXSID7021235 Css NA 9.573 mg/L 3compartmentss NA 95% Human Human -DTXSID7021235 Css NA 0.8422 mg/L PBTK NA 50% Human Human -DTXSID7021235 Css NA 5.691 mg/L PBTK NA 95% Human Human +DTXSID7021235 TK.Half.Life NA 1.856 hours 1compartment NA NA Human Human +DTXSID7021235 Css NA 0.738 mg/L 3compartmentss NA 50% Human Human +DTXSID7021235 Css NA 5.744 mg/L 3compartmentss NA 95% Human Human +DTXSID7021235 Css NA 0.4418 mg/L PBTK NA 50% Human Human +DTXSID7021235 Css NA 3.341 mg/L PBTK NA 95% Human Human DTXSID7021235 Clint NA 7.952 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021235 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021235 Vd NA 0.2577 L/kg 1compartment NA NA Rat Human +DTXSID7021235 Vd NA 0.2212 L/kg 1compartment NA NA Rat Human DTXSID7021235 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021235 TK.Half.Life NA 1.377 hours 1compartment NA NA Rat Human -DTXSID7021235 Css NA 0.7485 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021235 Css NA 3.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021235 Css NA 0.4258 mg/L PBTK NA 50% Rat Human -DTXSID7021235 Css NA 2.137 mg/L PBTK NA 95% Rat Human +DTXSID7021235 TK.Half.Life NA 1.181 hours 1compartment NA NA Rat Human +DTXSID7021235 Css NA 0.007874 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021235 Css NA 0.05034 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021235 Css NA 0.004407 mg/L PBTK NA 50% Rat Human +DTXSID7021235 Css NA 0.02779 mg/L PBTK NA 95% Rat Human DTXSID7021237 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7021237 Fup 0.005994 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID7021237 Vd NA 0.343 L/kg 1compartment NA NA Human Human -DTXSID7021237 Days.Css NA 95 Days PBTK NA NA Human Human -DTXSID7021237 TK.Half.Life NA 373.7 hours 1compartment NA NA Human Human -DTXSID7021237 Css NA 187.5 mg/L 3compartmentss NA 50% Human Human -DTXSID7021237 Css NA 1131 mg/L 3compartmentss NA 95% Human Human -DTXSID7021237 Css NA 110.7 mg/L PBTK NA 50% Human Human -DTXSID7021237 Css NA 663.3 mg/L PBTK NA 95% Human Human +DTXSID7021237 Vd NA 0.5512 L/kg 1compartment NA NA Human Human +DTXSID7021237 Days.Css NA 162 Days PBTK NA NA Human Human +DTXSID7021237 TK.Half.Life NA 617.8 hours 1compartment NA NA Human Human +DTXSID7021237 Css NA 184.8 mg/L 3compartmentss NA 50% Human Human +DTXSID7021237 Css NA 1109 mg/L 3compartmentss NA 95% Human Human +DTXSID7021237 Css NA 109.9 mg/L PBTK NA 50% Human Human +DTXSID7021237 Css NA 645.8 mg/L PBTK NA 95% Human Human DTXSID7021237 Clint 10.4 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID7021237 Fup 0.0143 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID7021237 Vd NA 0.4381 L/kg 1compartment NA NA Rat Rat -DTXSID7021237 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID7021237 TK.Half.Life NA 6.749 hours 1compartment NA NA Rat Rat -DTXSID7021237 Css NA 2.378 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7021237 Css NA 17.44 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7021237 Css NA 1.328 mg/L PBTK NA 50% Rat Rat -DTXSID7021237 Css NA 9.513 mg/L PBTK NA 95% Rat Rat -DTXSID7021283 Clint NA 0.05883 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021283 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021283 Vd NA 3.107 L/kg 1compartment NA NA Human Human -DTXSID7021283 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID7021283 TK.Half.Life NA 23260 hours 1compartment NA NA Human Human -DTXSID7021283 Css NA 904.8 mg/L 3compartmentss NA 50% Human Human -DTXSID7021283 Css NA 2982 mg/L 3compartmentss NA 95% Human Human -DTXSID7021283 Css NA 625.2 mg/L PBTK NA 50% Human Human -DTXSID7021283 Css NA 1976 mg/L PBTK NA 95% Human Human -DTXSID7021283 Clint NA 0.05883 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021283 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021283 Vd NA 2.327 L/kg 1compartment NA NA Rat Human -DTXSID7021283 Days.Css NA 2622 Days PBTK NA NA Rat Human -DTXSID7021283 TK.Half.Life NA 2371 hours 1compartment NA NA Rat Human -DTXSID7021283 Css NA 392.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021283 Css NA 926.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021283 Css NA 260.9 mg/L PBTK NA 50% Rat Human -DTXSID7021283 Css NA 570.4 mg/L PBTK NA 95% Rat Human +DTXSID7021237 Vd NA 0.6926 L/kg 1compartment NA NA Rat Rat +DTXSID7021237 Days.Css NA 1 Days PBTK NA NA Rat Rat +DTXSID7021237 TK.Half.Life NA 9.757 hours 1compartment NA NA Rat Rat +DTXSID7021237 Css NA 0.4922 mg/L 3compartmentss NA 50% Rat Rat +DTXSID7021237 Css NA 3.61 mg/L 3compartmentss NA 95% Rat Rat +DTXSID7021237 Css NA 0.2901 mg/L PBTK NA 50% Rat Rat +DTXSID7021237 Css NA 2.053 mg/L PBTK NA 95% Rat Rat +DTXSID7021239 Clint 10.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID7021239 Fup 0.00597 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID7021239 Vd NA 4.814 L/kg 1compartment NA NA Human Human +DTXSID7021239 Days.Css NA 58 Days PBTK NA NA Human Human +DTXSID7021239 TK.Half.Life NA 274.8 hours 1compartment NA NA Human Human +DTXSID7021239 Css NA 6.258 mg/L 3compartmentss NA 50% Human Human +DTXSID7021239 Css NA 43.51 mg/L 3compartmentss NA 95% Human Human +DTXSID7021239 Css NA 4.929 mg/L PBTK NA 50% Human Human +DTXSID7021239 Css NA 32.31 mg/L PBTK NA 95% Human Human +DTXSID7021239 Clint 6.9 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat +DTXSID7021239 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat +DTXSID7021239 Css NA 3.077 mg/L 3compartmentss NA 50% Rat Rat +DTXSID7021239 Css NA 14.45 mg/L 3compartmentss NA 95% Rat Rat +DTXSID70212557 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70212557 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70212557 Vd NA 0.4052 L/kg 1compartment NA NA Human Human +DTXSID70212557 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70212557 TK.Half.Life NA 2.512 hours 1compartment NA NA Human Human +DTXSID70212557 Css NA 0.9674 mg/L 3compartmentss NA 50% Human Human +DTXSID70212557 Css NA 9.509 mg/L 3compartmentss NA 95% Human Human +DTXSID70212557 Css NA 0.5793 mg/L PBTK NA 50% Human Human +DTXSID70212557 Css NA 5.589 mg/L PBTK NA 95% Human Human +DTXSID70212557 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70212557 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70212557 Vd NA 0.3295 L/kg 1compartment NA NA Rat Human +DTXSID70212557 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70212557 TK.Half.Life NA 1.298 hours 1compartment NA NA Rat Human +DTXSID70212557 Css NA 0.1206 mg/L 3compartmentss NA 50% Rat Human +DTXSID70212557 Css NA 0.8899 mg/L 3compartmentss NA 95% Rat Human +DTXSID70212557 Css NA 0.06956 mg/L PBTK NA 50% Rat Human +DTXSID70212557 Css NA 0.5038 mg/L PBTK NA 95% Rat Human DTXSID7021287 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021287 Fup NA 0.8724 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021287 Vd NA 0.7226 L/kg 1compartment NA NA Human Human +DTXSID7021287 Vd NA 0.7396 L/kg 1compartment NA NA Human Human DTXSID7021287 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021287 TK.Half.Life NA 5.361 hours 1compartment NA NA Human Human -DTXSID7021287 Css NA 0.9502 mg/L 3compartmentss NA 50% Human Human -DTXSID7021287 Css NA 5.38 mg/L 3compartmentss NA 95% Human Human -DTXSID7021287 Css NA 0.7762 mg/L PBTK NA 50% Human Human -DTXSID7021287 Css NA 3.529 mg/L PBTK NA 95% Human Human +DTXSID7021287 TK.Half.Life NA 5.488 hours 1compartment NA NA Human Human +DTXSID7021287 Css NA 0.8042 mg/L 3compartmentss NA 50% Human Human +DTXSID7021287 Css NA 4.729 mg/L 3compartmentss NA 95% Human Human +DTXSID7021287 Css NA 0.6653 mg/L PBTK NA 50% Human Human +DTXSID7021287 Css NA 3.042 mg/L PBTK NA 95% Human Human DTXSID7021287 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021287 Fup NA 0.8724 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021287 Vd NA 0.756 L/kg 1compartment NA NA Rat Human +DTXSID7021287 Vd NA 0.7707 L/kg 1compartment NA NA Rat Human DTXSID7021287 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021287 TK.Half.Life NA 1.911 hours 1compartment NA NA Rat Human -DTXSID7021287 Css NA 0.2428 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021287 Css NA 1.425 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021287 Css NA 0.1936 mg/L PBTK NA 50% Rat Human -DTXSID7021287 Css NA 0.853 mg/L PBTK NA 95% Rat Human -DTXSID7021289 Clint NA 18.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021289 Fup NA 0.2334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021289 Vd NA 1.47 L/kg 1compartment NA NA Human Human +DTXSID7021287 TK.Half.Life NA 1.948 hours 1compartment NA NA Rat Human +DTXSID7021287 Css NA 0.01495 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021287 Css NA 0.1054 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021287 Css NA 0.01189 mg/L PBTK NA 50% Rat Human +DTXSID7021287 Css NA 0.07005 mg/L PBTK NA 95% Rat Human +DTXSID7021289 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021289 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021289 Vd NA 1.548 L/kg 1compartment NA NA Human Human DTXSID7021289 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021289 TK.Half.Life NA 2.584 hours 1compartment NA NA Human Human -DTXSID7021289 Css NA 0.127 mg/L 3compartmentss NA 50% Human Human -DTXSID7021289 Css NA 0.84 mg/L 3compartmentss NA 95% Human Human -DTXSID7021289 Css NA 0.0932 mg/L PBTK NA 50% Human Human -DTXSID7021289 Css NA 0.5745 mg/L PBTK NA 95% Human Human -DTXSID7021289 Clint NA 18.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021289 Fup NA 0.2334 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021289 Vd NA 1.173 L/kg 1compartment NA NA Rat Human +DTXSID7021289 TK.Half.Life NA 2.821 hours 1compartment NA NA Human Human +DTXSID7021289 Css NA 0.1257 mg/L 3compartmentss NA 50% Human Human +DTXSID7021289 Css NA 0.8946 mg/L 3compartmentss NA 95% Human Human +DTXSID7021289 Css NA 0.09017 mg/L PBTK NA 50% Human Human +DTXSID7021289 Css NA 0.5989 mg/L PBTK NA 95% Human Human +DTXSID7021289 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021289 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021289 Vd NA 1.217 L/kg 1compartment NA NA Rat Human DTXSID7021289 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021289 TK.Half.Life NA 1.031 hours 1compartment NA NA Rat Human -DTXSID7021289 Css NA 0.06834 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021289 Css NA 0.3555 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021289 Css NA 0.04772 mg/L PBTK NA 50% Rat Human -DTXSID7021289 Css NA 0.231 mg/L PBTK NA 95% Rat Human +DTXSID7021289 TK.Half.Life NA 1.093 hours 1compartment NA NA Rat Human +DTXSID7021289 Css NA 0.0161 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021289 Css NA 0.08649 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021289 Css NA 0.01148 mg/L PBTK NA 50% Rat Human +DTXSID7021289 Css NA 0.05783 mg/L PBTK NA 95% Rat Human DTXSID7021310 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.30.12.1446 NA Human Human DTXSID7021310 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7021310 Vd NA 3.037 L/kg 1compartment NA NA Human Human DTXSID7021310 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID7021310 TK.Half.Life NA 26.29 hours 1compartment NA NA Human Human -DTXSID7021310 Css NA 0.2527 mg/L 3compartmentss NA 50% Human Human -DTXSID7021310 Css NA 1.664 mg/L 3compartmentss NA 95% Human Human -DTXSID7021310 Css NA 0.2386 mg/L PBTK NA 50% Human Human -DTXSID7021310 Css NA 1.124 mg/L PBTK NA 95% Human Human +DTXSID7021310 Css NA 0.6203 mg/L 3compartmentss NA 50% Human Human +DTXSID7021310 Css NA 3.063 mg/L 3compartmentss NA 95% Human Human +DTXSID7021310 Css NA 0.6203 mg/L PBTK NA 50% Human Human +DTXSID7021310 Css NA 3.063 mg/L PBTK NA 95% Human Human DTXSID7021310 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.30.12.1446 NA Rat Human DTXSID7021310 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7021310 Vd NA 3.092 L/kg 1compartment NA NA Rat Human DTXSID7021310 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7021310 TK.Half.Life NA 9.096 hours 1compartment NA NA Rat Human -DTXSID7021310 Css NA 0.2295 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021310 Css NA 1.609 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021310 Css NA 0.2119 mg/L PBTK NA 50% Rat Human -DTXSID7021310 Css NA 0.9996 mg/L PBTK NA 95% Rat Human -DTXSID7021312 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021312 Fup NA 0.3389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021312 Vd NA 1.431 L/kg 1compartment NA NA Human Human -DTXSID7021312 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7021312 TK.Half.Life NA 33.76 hours 1compartment NA NA Human Human -DTXSID7021312 Css NA 2.52 mg/L 3compartmentss NA 50% Human Human -DTXSID7021312 Css NA 9.947 mg/L 3compartmentss NA 95% Human Human -DTXSID7021312 Css NA 1.958 mg/L PBTK NA 50% Human Human -DTXSID7021312 Css NA 6.578 mg/L PBTK NA 95% Human Human -DTXSID7021312 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021312 Fup NA 0.3389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021312 Vd NA 1.176 L/kg 1compartment NA NA Rat Human +DTXSID7021310 Css NA 0.005054 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021310 Css NA 0.03995 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021310 Css NA 0.005079 mg/L PBTK NA 50% Rat Human +DTXSID7021310 Css NA 0.04025 mg/L PBTK NA 95% Rat Human +DTXSID7021312 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021312 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021312 Vd NA 0.8021 L/kg 1compartment NA NA Human Human +DTXSID7021312 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7021312 TK.Half.Life NA 2.43 hours 1compartment NA NA Human Human +DTXSID7021312 Css NA 0.2817 mg/L 3compartmentss NA 50% Human Human +DTXSID7021312 Css NA 1.696 mg/L 3compartmentss NA 95% Human Human +DTXSID7021312 Css NA 0.199 mg/L PBTK NA 50% Human Human +DTXSID7021312 Css NA 1.119 mg/L PBTK NA 95% Human Human +DTXSID7021312 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021312 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021312 Vd NA 0.7013 L/kg 1compartment NA NA Rat Human DTXSID7021312 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021312 TK.Half.Life NA 8.079 hours 1compartment NA NA Rat Human -DTXSID7021312 Css NA 0.6878 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021312 Css NA 2.214 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021312 Css NA 0.5123 mg/L PBTK NA 50% Rat Human -DTXSID7021312 Css NA 1.366 mg/L PBTK NA 95% Rat Human -DTXSID7021314 Clint NA 82.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021314 Fup NA 0.0284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021314 Vd NA 2.578 L/kg 1compartment NA NA Human Human -DTXSID7021314 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021314 TK.Half.Life NA 8.944 hours 1compartment NA NA Human Human -DTXSID7021314 Css NA 0.3944 mg/L 3compartmentss NA 50% Human Human -DTXSID7021314 Css NA 2.843 mg/L 3compartmentss NA 95% Human Human -DTXSID7021314 Css NA 0.2628 mg/L PBTK NA 50% Human Human -DTXSID7021314 Css NA 1.815 mg/L PBTK NA 95% Human Human -DTXSID7021314 Clint NA 82.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021314 Fup NA 0.0284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021314 Vd NA 1.927 L/kg 1compartment NA NA Rat Human -DTXSID7021314 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021314 TK.Half.Life NA 2.273 hours 1compartment NA NA Rat Human -DTXSID7021314 Css NA 0.2204 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021314 Css NA 1.338 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021314 Css NA 0.1398 mg/L PBTK NA 50% Rat Human -DTXSID7021314 Css NA 0.8201 mg/L PBTK NA 95% Rat Human -DTXSID7021316 Clint NA 0.9923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021316 Fup NA 0.0266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021316 Vd NA 2.912 L/kg 1compartment NA NA Human Human -DTXSID7021316 Days.Css NA 206 Days PBTK NA NA Human Human -DTXSID7021316 TK.Half.Life NA 827.5 hours 1compartment NA NA Human Human -DTXSID7021316 Css NA 37.86 mg/L 3compartmentss NA 50% Human Human -DTXSID7021316 Css NA 172.9 mg/L 3compartmentss NA 95% Human Human -DTXSID7021316 Css NA 25.9 mg/L PBTK NA 50% Human Human -DTXSID7021316 Css NA 113.2 mg/L PBTK NA 95% Human Human -DTXSID7021316 Clint NA 0.9923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021316 Fup NA 0.0266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021316 Vd NA 2.179 L/kg 1compartment NA NA Rat Human -DTXSID7021316 Days.Css NA 96 Days PBTK NA NA Rat Human -DTXSID7021316 TK.Half.Life NA 123.8 hours 1compartment NA NA Rat Human -DTXSID7021316 Css NA 18.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021316 Css NA 60.23 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021316 Css NA 12.1 mg/L PBTK NA 50% Rat Human -DTXSID7021316 Css NA 37.05 mg/L PBTK NA 95% Rat Human -DTXSID7021362 Clint NA 1.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021362 Fup NA 0.5299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021362 Vd NA 0.861 L/kg 1compartment NA NA Human Human +DTXSID7021312 TK.Half.Life NA 1.202 hours 1compartment NA NA Rat Human +DTXSID7021312 Css NA 0.03324 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021312 Css NA 0.1524 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021312 Css NA 0.02334 mg/L PBTK NA 50% Rat Human +DTXSID7021312 Css NA 0.09628 mg/L PBTK NA 95% Rat Human +DTXSID7021314 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021314 Fup 0.00984 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021314 Vd NA 2.258 L/kg 1compartment NA NA Human Human +DTXSID7021314 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID7021314 TK.Half.Life NA 37.49 hours 1compartment NA NA Human Human +DTXSID7021314 Css NA 2.466 mg/L 3compartmentss NA 50% Human Human +DTXSID7021314 Css NA 19.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7021314 Css NA 1.594 mg/L PBTK NA 50% Human Human +DTXSID7021314 Css NA 12.09 mg/L PBTK NA 95% Human Human +DTXSID7021314 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021314 Fup 0.00984 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021314 Vd NA 1.678 L/kg 1compartment NA NA Rat Human +DTXSID7021314 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7021314 TK.Half.Life NA 10.59 hours 1compartment NA NA Rat Human +DTXSID7021314 Css NA 0.3183 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021314 Css NA 2.146 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021314 Css NA 0.2015 mg/L PBTK NA 50% Rat Human +DTXSID7021314 Css NA 1.313 mg/L PBTK NA 95% Rat Human +DTXSID7021316 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021316 Fup 0.00485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021316 Vd NA 2.231 L/kg 1compartment NA NA Human Human +DTXSID7021316 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID7021316 TK.Half.Life NA 51.61 hours 1compartment NA NA Human Human +DTXSID7021316 Css NA 3.492 mg/L 3compartmentss NA 50% Human Human +DTXSID7021316 Css NA 28.54 mg/L 3compartmentss NA 95% Human Human +DTXSID7021316 Css NA 2.237 mg/L PBTK NA 50% Human Human +DTXSID7021316 Css NA 17.83 mg/L PBTK NA 95% Human Human +DTXSID7021316 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021316 Fup 0.00485 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021316 Vd NA 1.654 L/kg 1compartment NA NA Rat Human +DTXSID7021316 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID7021316 TK.Half.Life NA 14.75 hours 1compartment NA NA Rat Human +DTXSID7021316 Css NA 0.4618 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021316 Css NA 3.002 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021316 Css NA 0.2901 mg/L PBTK NA 50% Rat Human +DTXSID7021316 Css NA 1.809 mg/L PBTK NA 95% Rat Human +DTXSID7021362 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021362 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021362 Vd NA 0.6706 L/kg 1compartment NA NA Human Human DTXSID7021362 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021362 TK.Half.Life NA 3.519 hours 1compartment NA NA Human Human -DTXSID7021362 Css NA 0.4092 mg/L 3compartmentss NA 50% Human Human -DTXSID7021362 Css NA 2.636 mg/L 3compartmentss NA 95% Human Human -DTXSID7021362 Css NA 0.3296 mg/L PBTK NA 50% Human Human -DTXSID7021362 Css NA 1.745 mg/L PBTK NA 95% Human Human -DTXSID7021362 Clint NA 1.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021362 Fup NA 0.5299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021362 Vd NA 0.8171 L/kg 1compartment NA NA Rat Human +DTXSID7021362 TK.Half.Life NA 1.533 hours 1compartment NA NA Human Human +DTXSID7021362 Css NA 0.1924 mg/L 3compartmentss NA 50% Human Human +DTXSID7021362 Css NA 1.231 mg/L 3compartmentss NA 95% Human Human +DTXSID7021362 Css NA 0.1405 mg/L PBTK NA 50% Human Human +DTXSID7021362 Css NA 0.8185 mg/L PBTK NA 95% Human Human +DTXSID7021362 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021362 Fup 0.344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021362 Vd NA 0.6346 L/kg 1compartment NA NA Rat Human DTXSID7021362 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021362 TK.Half.Life NA 1.672 hours 1compartment NA NA Rat Human -DTXSID7021362 Css NA 0.1717 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021362 Css NA 0.9577 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021362 Css NA 0.1347 mg/L PBTK NA 50% Rat Human -DTXSID7021362 Css NA 0.5726 mg/L PBTK NA 95% Rat Human -DTXSID7021364 Clint NA 1.691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021364 Fup NA 0.6443 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021364 Vd NA 1.269 L/kg 1compartment NA NA Human Human +DTXSID7021362 TK.Half.Life NA 0.8146 hours 1compartment NA NA Rat Human +DTXSID7021362 Css NA 0.02236 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021362 Css NA 0.1094 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021362 Css NA 0.01623 mg/L PBTK NA 50% Rat Human +DTXSID7021362 Css NA 0.07021 mg/L PBTK NA 95% Rat Human +DTXSID7021364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021364 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021364 Vd NA 1.406 L/kg 1compartment NA NA Human Human DTXSID7021364 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021364 TK.Half.Life NA 4.025 hours 1compartment NA NA Human Human -DTXSID7021364 Css NA 0.3058 mg/L 3compartmentss NA 50% Human Human -DTXSID7021364 Css NA 2.45 mg/L 3compartmentss NA 95% Human Human -DTXSID7021364 Css NA 0.2654 mg/L PBTK NA 50% Human Human -DTXSID7021364 Css NA 1.636 mg/L PBTK NA 95% Human Human -DTXSID7021364 Clint NA 1.691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021364 Fup NA 0.6443 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021364 Vd NA 1.14 L/kg 1compartment NA NA Rat Human +DTXSID7021364 TK.Half.Life NA 1.298 hours 1compartment NA NA Human Human +DTXSID7021364 Css NA 0.03495 mg/L 3compartmentss NA 50% Human Human +DTXSID7021364 Css NA 0.3903 mg/L 3compartmentss NA 95% Human Human +DTXSID7021364 Css NA 0.0297 mg/L PBTK NA 50% Human Human +DTXSID7021364 Css NA 0.2744 mg/L PBTK NA 95% Human Human +DTXSID7021364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021364 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021364 Vd NA 1.22 L/kg 1compartment NA NA Rat Human DTXSID7021364 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021364 TK.Half.Life NA 1.766 hours 1compartment NA NA Rat Human -DTXSID7021364 Css NA 0.1264 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021364 Css NA 0.901 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021364 Css NA 0.1085 mg/L PBTK NA 50% Rat Human -DTXSID7021364 Css NA 0.5523 mg/L PBTK NA 95% Rat Human -DTXSID7021366 Clint NA 0.9094 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021366 Fup NA 0.4749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021366 Vd NA 1.023 L/kg 1compartment NA NA Human Human +DTXSID7021364 TK.Half.Life NA 0.5436 hours 1compartment NA NA Rat Human +DTXSID7021364 Css NA 0.004276 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021364 Css NA 0.04 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021364 Css NA 0.0037 mg/L PBTK NA 50% Rat Human +DTXSID7021364 Css NA 0.02683 mg/L PBTK NA 95% Rat Human +DTXSID7021366 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021366 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021366 Vd NA 1.057 L/kg 1compartment NA NA Human Human DTXSID7021366 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021366 TK.Half.Life NA 6.07 hours 1compartment NA NA Human Human -DTXSID7021366 Css NA 0.5952 mg/L 3compartmentss NA 50% Human Human -DTXSID7021366 Css NA 3.346 mg/L 3compartmentss NA 95% Human Human -DTXSID7021366 Css NA 0.4817 mg/L PBTK NA 50% Human Human -DTXSID7021366 Css NA 2.206 mg/L PBTK NA 95% Human Human -DTXSID7021366 Clint NA 0.9094 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021366 Fup NA 0.4749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021366 Vd NA 0.9234 L/kg 1compartment NA NA Rat Human +DTXSID7021366 TK.Half.Life NA 1.028 hours 1compartment NA NA Human Human +DTXSID7021366 Css NA 0.03767 mg/L 3compartmentss NA 50% Human Human +DTXSID7021366 Css NA 0.3385 mg/L 3compartmentss NA 95% Human Human +DTXSID7021366 Css NA 0.03042 mg/L PBTK NA 50% Human Human +DTXSID7021366 Css NA 0.2413 mg/L PBTK NA 95% Human Human +DTXSID7021366 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021366 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021366 Vd NA 0.9562 L/kg 1compartment NA NA Rat Human DTXSID7021366 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021366 TK.Half.Life NA 2.536 hours 1compartment NA NA Rat Human -DTXSID7021366 Css NA 0.2349 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021366 Css NA 1.106 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021366 Css NA 0.1837 mg/L PBTK NA 50% Rat Human -DTXSID7021366 Css NA 0.6778 mg/L PBTK NA 95% Rat Human -DTXSID7021368 Clint NA 0.2479 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021368 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021368 Vd NA 3.094 L/kg 1compartment NA NA Human Human -DTXSID7021368 Days.Css NA 1771 Days PBTK NA NA Human Human -DTXSID7021368 TK.Half.Life NA 6490 hours 1compartment NA NA Human Human -DTXSID7021368 Css NA 262.6 mg/L 3compartmentss NA 50% Human Human -DTXSID7021368 Css NA 1154 mg/L 3compartmentss NA 95% Human Human -DTXSID7021368 Css NA 182.4 mg/L PBTK NA 50% Human Human -DTXSID7021368 Css NA 756.8 mg/L PBTK NA 95% Human Human -DTXSID7021368 Clint NA 0.2479 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021368 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021368 Vd NA 2.317 L/kg 1compartment NA NA Rat Human -DTXSID7021368 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID7021368 TK.Half.Life NA 783.8 hours 1compartment NA NA Rat Human -DTXSID7021368 Css NA 132.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021368 Css NA 405.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021368 Css NA 87.8 mg/L PBTK NA 50% Rat Human -DTXSID7021368 Css NA 255.8 mg/L PBTK NA 95% Rat Human +DTXSID7021366 TK.Half.Life NA 0.4633 hours 1compartment NA NA Rat Human +DTXSID7021366 Css NA 0.004652 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021366 Css NA 0.03371 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021366 Css NA 0.003824 mg/L PBTK NA 50% Rat Human +DTXSID7021366 Css NA 0.02315 mg/L PBTK NA 95% Rat Human +DTXSID7021493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021493 Fup 0.0686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021493 Vd NA 3.006 L/kg 1compartment NA NA Human Human +DTXSID7021493 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID7021493 TK.Half.Life NA 36.93 hours 1compartment NA NA Human Human +DTXSID7021493 Css NA 1.448 mg/L 3compartmentss NA 50% Human Human +DTXSID7021493 Css NA 8.959 mg/L 3compartmentss NA 95% Human Human +DTXSID7021493 Css NA 0.9976 mg/L PBTK NA 50% Human Human +DTXSID7021493 Css NA 5.951 mg/L PBTK NA 95% Human Human +DTXSID7021493 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021493 Fup 0.0686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021493 Vd NA 2.255 L/kg 1compartment NA NA Rat Human +DTXSID7021493 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7021493 TK.Half.Life NA 6.043 hours 1compartment NA NA Rat Human +DTXSID7021493 Css NA 0.1846 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021493 Css NA 1.035 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021493 Css NA 0.1268 mg/L PBTK NA 50% Rat Human +DTXSID7021493 Css NA 0.6943 mg/L PBTK NA 95% Rat Human DTXSID7021495 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021495 Fup NA 0.4884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021495 Vd NA 0.591 L/kg 1compartment NA NA Human Human DTXSID7021495 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7021495 TK.Half.Life NA 7.829 hours 1compartment NA NA Human Human -DTXSID7021495 Css NA 1.437 mg/L 3compartmentss NA 50% Human Human -DTXSID7021495 Css NA 7.404 mg/L 3compartmentss NA 95% Human Human -DTXSID7021495 Css NA 1.117 mg/L PBTK NA 50% Human Human -DTXSID7021495 Css NA 4.667 mg/L PBTK NA 95% Human Human +DTXSID7021495 Css NA 1.224 mg/L 3compartmentss NA 50% Human Human +DTXSID7021495 Css NA 6.426 mg/L 3compartmentss NA 95% Human Human +DTXSID7021495 Css NA 0.951 mg/L PBTK NA 50% Human Human +DTXSID7021495 Css NA 4.103 mg/L PBTK NA 95% Human Human DTXSID7021495 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021495 Fup NA 0.4884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021495 Vd NA 0.6056 L/kg 1compartment NA NA Rat Human DTXSID7021495 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7021495 TK.Half.Life NA 2.734 hours 1compartment NA NA Rat Human -DTXSID7021495 Css NA 0.3926 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021495 Css NA 1.76 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021495 Css NA 0.291 mg/L PBTK NA 50% Rat Human -DTXSID7021495 Css NA 1.049 mg/L PBTK NA 95% Rat Human -DTXSID7021520 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021520 Fup NA 0.5384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021520 Vd NA 1.118 L/kg 1compartment NA NA Human Human +DTXSID7021495 Css NA 0.02296 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021495 Css NA 0.1628 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021495 Css NA 0.01723 mg/L PBTK NA 50% Rat Human +DTXSID7021495 Css NA 0.1048 mg/L PBTK NA 95% Rat Human +DTXSID7021520 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021520 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021520 Vd NA 1.003 L/kg 1compartment NA NA Human Human DTXSID7021520 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7021520 TK.Half.Life NA 13.74 hours 1compartment NA NA Human Human -DTXSID7021520 Css NA 1.28 mg/L 3compartmentss NA 50% Human Human -DTXSID7021520 Css NA 7.921 mg/L 3compartmentss NA 95% Human Human -DTXSID7021520 Css NA 1.077 mg/L PBTK NA 50% Human Human -DTXSID7021520 Css NA 5.209 mg/L PBTK NA 95% Human Human -DTXSID7021520 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021520 Fup NA 0.5384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021520 Vd NA 1.088 L/kg 1compartment NA NA Rat Human +DTXSID7021520 TK.Half.Life NA 10.34 hours 1compartment NA NA Human Human +DTXSID7021520 Css NA 1.088 mg/L 3compartmentss NA 50% Human Human +DTXSID7021520 Css NA 7.576 mg/L 3compartmentss NA 95% Human Human +DTXSID7021520 Css NA 0.9136 mg/L PBTK NA 50% Human Human +DTXSID7021520 Css NA 4.83 mg/L PBTK NA 95% Human Human +DTXSID7021520 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021520 Fup 0.632 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021520 Vd NA 1.003 L/kg 1compartment NA NA Rat Human DTXSID7021520 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021520 TK.Half.Life NA 4.478 hours 1compartment NA NA Rat Human -DTXSID7021520 Css NA 0.3369 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021520 Css NA 1.977 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021520 Css NA 0.2746 mg/L PBTK NA 50% Rat Human -DTXSID7021520 Css NA 1.193 mg/L PBTK NA 95% Rat Human -DTXSID7021526 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021526 Fup NA 0.6282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021526 Vd NA 0.6515 L/kg 1compartment NA NA Human Human +DTXSID7021520 TK.Half.Life NA 3.506 hours 1compartment NA NA Rat Human +DTXSID7021520 Css NA 0.06575 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021520 Css NA 0.4188 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021520 Css NA 0.05564 mg/L PBTK NA 50% Rat Human +DTXSID7021520 Css NA 0.2599 mg/L PBTK NA 95% Rat Human +DTXSID7021526 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021526 Fup 0.74 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021526 Vd NA 0.7169 L/kg 1compartment NA NA Human Human DTXSID7021526 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021526 TK.Half.Life NA 6.71 hours 1compartment NA NA Human Human -DTXSID7021526 Css NA 1.183 mg/L 3compartmentss NA 50% Human Human -DTXSID7021526 Css NA 8.019 mg/L 3compartmentss NA 95% Human Human -DTXSID7021526 Css NA 0.9506 mg/L PBTK NA 50% Human Human -DTXSID7021526 Css NA 4.992 mg/L PBTK NA 95% Human Human -DTXSID7021526 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021526 Fup NA 0.6282 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021526 Vd NA 0.6732 L/kg 1compartment NA NA Rat Human +DTXSID7021526 TK.Half.Life NA 6.267 hours 1compartment NA NA Human Human +DTXSID7021526 Css NA 0.8722 mg/L 3compartmentss NA 50% Human Human +DTXSID7021526 Css NA 5.803 mg/L 3compartmentss NA 95% Human Human +DTXSID7021526 Css NA 0.7256 mg/L PBTK NA 50% Human Human +DTXSID7021526 Css NA 3.734 mg/L PBTK NA 95% Human Human +DTXSID7021526 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021526 Fup 0.74 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021526 Vd NA 0.7416 L/kg 1compartment NA NA Rat Human DTXSID7021526 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021526 TK.Half.Life NA 2.362 hours 1compartment NA NA Rat Human -DTXSID7021526 Css NA 0.3118 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021526 Css NA 1.956 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021526 Css NA 0.2402 mg/L PBTK NA 50% Rat Human -DTXSID7021526 Css NA 1.15 mg/L PBTK NA 95% Rat Human +DTXSID7021526 TK.Half.Life NA 2.21 hours 1compartment NA NA Rat Human +DTXSID7021526 Css NA 0.01694 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021526 Css NA 0.1402 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021526 Css NA 0.01344 mg/L PBTK NA 50% Rat Human +DTXSID7021526 Css NA 0.08993 mg/L PBTK NA 95% Rat Human DTXSID70215523 Clint 26 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID70215523 Fup 0.22 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID70215523 Vd NA 0.9986 L/kg 1compartment NA NA Human Human +DTXSID70215523 Vd NA 1.076 L/kg 1compartment NA NA Human Human DTXSID70215523 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID70215523 TK.Half.Life NA 1.443 hours 1compartment NA NA Human Human -DTXSID70215523 Css NA 0.08735 mg/L 3compartmentss NA 50% Human Human -DTXSID70215523 Css NA 0.6004 mg/L 3compartmentss NA 95% Human Human -DTXSID70215523 Css NA 0.0617 mg/L PBTK NA 50% Human Human -DTXSID70215523 Css NA 0.3956 mg/L PBTK NA 95% Human Human +DTXSID70215523 TK.Half.Life NA 1.563 hours 1compartment NA NA Human Human +DTXSID70215523 Css NA 0.0829 mg/L 3compartmentss NA 50% Human Human +DTXSID70215523 Css NA 0.6138 mg/L 3compartmentss NA 95% Human Human +DTXSID70215523 Css NA 0.0591 mg/L PBTK NA 50% Human Human +DTXSID70215523 Css NA 0.4055 mg/L PBTK NA 95% Human Human DTXSID70215523 Clint 58.75 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID70215523 Fup 0.22 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID70215523 Vd NA 0.8321 L/kg 1compartment NA NA Rat Rat +DTXSID70215523 Vd NA 0.8874 L/kg 1compartment NA NA Rat Rat DTXSID70215523 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID70215523 TK.Half.Life NA 0.4443 hours 1compartment NA NA Rat Rat -DTXSID70215523 Css NA 0.02155 mg/L 3compartmentss NA 50% Rat Rat -DTXSID70215523 Css NA 0.1262 mg/L 3compartmentss NA 95% Rat Rat -DTXSID70215523 Css NA 0.01457 mg/L PBTK NA 50% Rat Rat -DTXSID70215523 Css NA 0.07963 mg/L PBTK NA 95% Rat Rat +DTXSID70215523 TK.Half.Life NA 0.4725 hours 1compartment NA NA Rat Rat +DTXSID70215523 Css NA 0.0047 mg/L 3compartmentss NA 50% Rat Rat +DTXSID70215523 Css NA 0.02962 mg/L 3compartmentss NA 95% Rat Rat +DTXSID70215523 Css NA 0.00331 mg/L PBTK NA 50% Rat Rat +DTXSID70215523 Css NA 0.01989 mg/L PBTK NA 95% Rat Rat DTXSID7021576 Clint NA 0.1335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021576 Fup NA 0.8182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021576 Vd NA 1.255 L/kg 1compartment NA NA Human Human +DTXSID7021576 Vd NA 1.022 L/kg 1compartment NA NA Human Human DTXSID7021576 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021576 TK.Half.Life NA 8.682 hours 1compartment NA NA Human Human -DTXSID7021576 Css NA 0.7358 mg/L 3compartmentss NA 50% Human Human -DTXSID7021576 Css NA 4.696 mg/L 3compartmentss NA 95% Human Human -DTXSID7021576 Css NA 0.6656 mg/L PBTK NA 50% Human Human -DTXSID7021576 Css NA 3.138 mg/L PBTK NA 95% Human Human +DTXSID7021576 TK.Half.Life NA 6.789 hours 1compartment NA NA Human Human +DTXSID7021576 Css NA 0.6312 mg/L 3compartmentss NA 50% Human Human +DTXSID7021576 Css NA 3.923 mg/L 3compartmentss NA 95% Human Human +DTXSID7021576 Css NA 0.5542 mg/L PBTK NA 50% Human Human +DTXSID7021576 Css NA 2.595 mg/L PBTK NA 95% Human Human DTXSID7021576 Clint NA 0.1335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021576 Fup NA 0.8182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021576 Vd NA 1.167 L/kg 1compartment NA NA Rat Human +DTXSID7021576 Vd NA 0.993 L/kg 1compartment NA NA Rat Human DTXSID7021576 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021576 TK.Half.Life NA 2.883 hours 1compartment NA NA Rat Human -DTXSID7021576 Css NA 0.2095 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021576 Css NA 1.369 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021576 Css NA 0.1855 mg/L PBTK NA 50% Rat Human -DTXSID7021576 Css NA 0.8467 mg/L PBTK NA 95% Rat Human -DTXSID7021603 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021603 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021603 Vd NA 4.563 L/kg 1compartment NA NA Human Human -DTXSID7021603 Days.Css NA 1148 Days PBTK NA NA Human Human -DTXSID7021603 TK.Half.Life NA 4268 hours 1compartment NA NA Human Human -DTXSID7021603 Css NA 114.6 mg/L 3compartmentss NA 50% Human Human -DTXSID7021603 Css NA 620 mg/L 3compartmentss NA 95% Human Human -DTXSID7021603 Css NA 90.05 mg/L PBTK NA 50% Human Human -DTXSID7021603 Css NA 398.7 mg/L PBTK NA 95% Human Human -DTXSID7021603 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021603 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021603 Vd NA 3.489 L/kg 1compartment NA NA Rat Human -DTXSID7021603 Days.Css NA 297 Days PBTK NA NA Rat Human -DTXSID7021603 TK.Half.Life NA 761.7 hours 1compartment NA NA Rat Human -DTXSID7021603 Css NA 30.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021603 Css NA 150.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021603 Css NA 23.34 mg/L PBTK NA 50% Rat Human -DTXSID7021603 Css NA 89.74 mg/L PBTK NA 95% Rat Human +DTXSID7021576 TK.Half.Life NA 2.431 hours 1compartment NA NA Rat Human +DTXSID7021576 Css NA 0.01312 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021576 Css NA 0.1111 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021576 Css NA 0.01118 mg/L PBTK NA 50% Rat Human +DTXSID7021576 Css NA 0.07385 mg/L PBTK NA 95% Rat Human +DTXSID7021603 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021603 Fup 0.0336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021603 Vd NA 5.969 L/kg 1compartment NA NA Human Human +DTXSID7021603 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID7021603 TK.Half.Life NA 51.08 hours 1compartment NA NA Human Human +DTXSID7021603 Css NA 0.896 mg/L 3compartmentss NA 50% Human Human +DTXSID7021603 Css NA 6.256 mg/L 3compartmentss NA 95% Human Human +DTXSID7021603 Css NA 0.7952 mg/L PBTK NA 50% Human Human +DTXSID7021603 Css NA 4.933 mg/L PBTK NA 95% Human Human +DTXSID7021603 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021603 Fup 0.0336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021603 Vd NA 4.618 L/kg 1compartment NA NA Rat Human +DTXSID7021603 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID7021603 TK.Half.Life NA 13.68 hours 1compartment NA NA Rat Human +DTXSID7021603 Css NA 0.1095 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021603 Css NA 0.6403 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021603 Css NA 0.09983 mg/L PBTK NA 50% Rat Human +DTXSID7021603 Css NA 0.5329 mg/L PBTK NA 95% Rat Human DTXSID7021605 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021605 Fup NA 0.6157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021605 Vd NA 0.5691 L/kg 1compartment NA NA Human Human DTXSID7021605 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7021605 TK.Half.Life NA 5.981 hours 1compartment NA NA Human Human -DTXSID7021605 Css NA 1.239 mg/L 3compartmentss NA 50% Human Human -DTXSID7021605 Css NA 8.012 mg/L 3compartmentss NA 95% Human Human -DTXSID7021605 Css NA 0.9706 mg/L PBTK NA 50% Human Human -DTXSID7021605 Css NA 4.985 mg/L PBTK NA 95% Human Human +DTXSID7021605 Css NA 1.191 mg/L 3compartmentss NA 50% Human Human +DTXSID7021605 Css NA 7.882 mg/L 3compartmentss NA 95% Human Human +DTXSID7021605 Css NA 0.9329 mg/L PBTK NA 50% Human Human +DTXSID7021605 Css NA 4.975 mg/L PBTK NA 95% Human Human DTXSID7021605 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021605 Fup NA 0.6157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021605 Vd NA 0.5865 L/kg 1compartment NA NA Rat Human DTXSID7021605 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7021605 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human -DTXSID7021605 Css NA 0.3276 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021605 Css NA 2.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021605 Css NA 0.245 mg/L PBTK NA 50% Rat Human -DTXSID7021605 Css NA 1.189 mg/L PBTK NA 95% Rat Human -DTXSID7021607 Clint NA 0.06368 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021607 Fup NA 0.3552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021607 Vd NA 0.4959 L/kg 1compartment NA NA Human Human +DTXSID7021605 Css NA 0.07296 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021605 Css NA 0.4707 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021605 Css NA 0.0566 mg/L PBTK NA 50% Rat Human +DTXSID7021605 Css NA 0.2837 mg/L PBTK NA 95% Rat Human +DTXSID7021607 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021607 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021607 Vd NA 0.5828 L/kg 1compartment NA NA Human Human DTXSID7021607 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021607 TK.Half.Life NA 8.179 hours 1compartment NA NA Human Human -DTXSID7021607 Css NA 1.816 mg/L 3compartmentss NA 50% Human Human -DTXSID7021607 Css NA 7.603 mg/L 3compartmentss NA 95% Human Human -DTXSID7021607 Css NA 1.336 mg/L PBTK NA 50% Human Human -DTXSID7021607 Css NA 4.862 mg/L PBTK NA 95% Human Human -DTXSID7021607 Clint NA 0.06368 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021607 Fup NA 0.3552 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021607 Vd NA 0.4935 L/kg 1compartment NA NA Rat Human +DTXSID7021607 TK.Half.Life NA 7.927 hours 1compartment NA NA Human Human +DTXSID7021607 Css NA 1.235 mg/L 3compartmentss NA 50% Human Human +DTXSID7021607 Css NA 6.247 mg/L 3compartmentss NA 95% Human Human +DTXSID7021607 Css NA 0.9712 mg/L PBTK NA 50% Human Human +DTXSID7021607 Css NA 4.056 mg/L PBTK NA 95% Human Human +DTXSID7021607 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021607 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021607 Vd NA 0.581 L/kg 1compartment NA NA Rat Human DTXSID7021607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021607 TK.Half.Life NA 2.914 hours 1compartment NA NA Rat Human -DTXSID7021607 Css NA 0.5266 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021607 Css NA 2.003 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021607 Css NA 0.371 mg/L PBTK NA 50% Rat Human -DTXSID7021607 Css NA 1.184 mg/L PBTK NA 95% Rat Human -DTXSID7021655 Clint NA 0.01516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021655 Fup NA 0.422 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021655 Vd NA 0.4714 L/kg 1compartment NA NA Human Human +DTXSID7021607 TK.Half.Life NA 2.692 hours 1compartment NA NA Rat Human +DTXSID7021607 Css NA 0.02288 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021607 Css NA 0.1601 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021607 Css NA 0.01755 mg/L PBTK NA 50% Rat Human +DTXSID7021607 Css NA 0.105 mg/L PBTK NA 95% Rat Human +DTXSID7021655 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021655 Fup 0.639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021655 Vd NA 0.5922 L/kg 1compartment NA NA Human Human DTXSID7021655 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021655 TK.Half.Life NA 7.051 hours 1compartment NA NA Human Human -DTXSID7021655 Css NA 1.684 mg/L 3compartmentss NA 50% Human Human -DTXSID7021655 Css NA 7.662 mg/L 3compartmentss NA 95% Human Human -DTXSID7021655 Css NA 1.241 mg/L PBTK NA 50% Human Human -DTXSID7021655 Css NA 4.832 mg/L PBTK NA 95% Human Human -DTXSID7021655 Clint NA 0.01516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021655 Fup NA 0.422 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021655 Vd NA 0.4737 L/kg 1compartment NA NA Rat Human +DTXSID7021655 TK.Half.Life NA 5.996 hours 1compartment NA NA Human Human +DTXSID7021655 Css NA 1 mg/L 3compartmentss NA 50% Human Human +DTXSID7021655 Css NA 6.68 mg/L 3compartmentss NA 95% Human Human +DTXSID7021655 Css NA 0.7968 mg/L PBTK NA 50% Human Human +DTXSID7021655 Css NA 4.234 mg/L PBTK NA 95% Human Human +DTXSID7021655 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021655 Fup 0.639 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021655 Vd NA 0.5963 L/kg 1compartment NA NA Rat Human DTXSID7021655 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021655 TK.Half.Life NA 2.445 hours 1compartment NA NA Rat Human -DTXSID7021655 Css NA 0.4686 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021655 Css NA 1.849 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021655 Css NA 0.3282 mg/L PBTK NA 50% Rat Human -DTXSID7021655 Css NA 1.088 mg/L PBTK NA 95% Rat Human -DTXSID7021657 Clint NA 7.408 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021657 Fup NA 0.4777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021657 Vd NA 1.08 L/kg 1compartment NA NA Human Human +DTXSID7021655 TK.Half.Life NA 2.057 hours 1compartment NA NA Rat Human +DTXSID7021655 Css NA 0.01904 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021655 Css NA 0.1543 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021655 Css NA 0.01453 mg/L PBTK NA 50% Rat Human +DTXSID7021655 Css NA 0.09919 mg/L PBTK NA 95% Rat Human +DTXSID7021657 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021657 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021657 Vd NA 0.8487 L/kg 1compartment NA NA Human Human DTXSID7021657 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021657 TK.Half.Life NA 1.766 hours 1compartment NA NA Human Human -DTXSID7021657 Css NA 0.12 mg/L 3compartmentss NA 50% Human Human -DTXSID7021657 Css NA 0.8746 mg/L 3compartmentss NA 95% Human Human -DTXSID7021657 Css NA 0.097 mg/L PBTK NA 50% Human Human -DTXSID7021657 Css NA 0.6034 mg/L PBTK NA 95% Human Human -DTXSID7021657 Clint NA 7.408 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021657 Fup NA 0.4777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021657 Vd NA 0.9647 L/kg 1compartment NA NA Rat Human +DTXSID7021657 TK.Half.Life NA 2.106 hours 1compartment NA NA Human Human +DTXSID7021657 Css NA 0.2114 mg/L 3compartmentss NA 50% Human Human +DTXSID7021657 Css NA 1.345 mg/L 3compartmentss NA 95% Human Human +DTXSID7021657 Css NA 0.1549 mg/L PBTK NA 50% Human Human +DTXSID7021657 Css NA 0.9167 mg/L PBTK NA 95% Human Human +DTXSID7021657 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021657 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021657 Vd NA 0.7553 L/kg 1compartment NA NA Rat Human DTXSID7021657 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021657 TK.Half.Life NA 0.8398 hours 1compartment NA NA Rat Human -DTXSID7021657 Css NA 0.0601 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021657 Css NA 0.3601 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021657 Css NA 0.04698 mg/L PBTK NA 50% Rat Human -DTXSID7021657 Css NA 0.2308 mg/L PBTK NA 95% Rat Human +DTXSID7021657 TK.Half.Life NA 1.044 hours 1compartment NA NA Rat Human +DTXSID7021657 Css NA 0.02469 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021657 Css NA 0.1222 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021657 Css NA 0.01815 mg/L PBTK NA 50% Rat Human +DTXSID7021657 Css NA 0.07908 mg/L PBTK NA 95% Rat Human DTXSID7021659 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021659 Fup NA 0.5468 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021659 Vd NA 0.537 L/kg 1compartment NA NA Human Human DTXSID7021659 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7021659 TK.Half.Life NA 6.353 hours 1compartment NA NA Human Human -DTXSID7021659 Css NA 1.394 mg/L 3compartmentss NA 50% Human Human -DTXSID7021659 Css NA 8.618 mg/L 3compartmentss NA 95% Human Human -DTXSID7021659 Css NA 1.06 mg/L PBTK NA 50% Human Human -DTXSID7021659 Css NA 5.317 mg/L PBTK NA 95% Human Human +DTXSID7021659 Css NA 1.169 mg/L 3compartmentss NA 50% Human Human +DTXSID7021659 Css NA 7.168 mg/L 3compartmentss NA 95% Human Human +DTXSID7021659 Css NA 0.8898 mg/L PBTK NA 50% Human Human +DTXSID7021659 Css NA 4.438 mg/L PBTK NA 95% Human Human DTXSID7021659 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021659 Fup NA 0.5468 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021659 Vd NA 0.5622 L/kg 1compartment NA NA Rat Human DTXSID7021659 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7021659 TK.Half.Life NA 2.267 hours 1compartment NA NA Rat Human -DTXSID7021659 Css NA 0.3677 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021659 Css NA 2.046 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021659 Css NA 0.2672 mg/L PBTK NA 50% Rat Human -DTXSID7021659 Css NA 1.191 mg/L PBTK NA 95% Rat Human +DTXSID7021659 Css NA 0.02182 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021659 Css NA 0.1801 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021659 Css NA 0.01606 mg/L PBTK NA 50% Rat Human +DTXSID7021659 Css NA 0.1123 mg/L PBTK NA 95% Rat Human DTXSID7021780 Clint 42.5 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID7021780 Fup 0.19 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human -DTXSID7021780 Vd NA 1.511 L/kg 1compartment NA NA Human Human +DTXSID7021780 Vd NA 1.523 L/kg 1compartment NA NA Human Human DTXSID7021780 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021780 TK.Half.Life NA 2.082 hours 1compartment NA NA Human Human -DTXSID7021780 Css NA 0.07525 mg/L 3compartmentss NA 50% Human Human -DTXSID7021780 Css NA 0.4991 mg/L 3compartmentss NA 95% Human Human -DTXSID7021780 Css NA 0.05179 mg/L PBTK NA 50% Human Human -DTXSID7021780 Css NA 0.333 mg/L PBTK NA 95% Human Human +DTXSID7021780 TK.Half.Life NA 2.103 hours 1compartment NA NA Human Human +DTXSID7021780 Css NA 0.07098 mg/L 3compartmentss NA 50% Human Human +DTXSID7021780 Css NA 0.5267 mg/L 3compartmentss NA 95% Human Human +DTXSID7021780 Css NA 0.04872 mg/L PBTK NA 50% Human Human +DTXSID7021780 Css NA 0.347 mg/L PBTK NA 95% Human Human DTXSID7021780 Clint 42.5 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID7021780 Fup 0.19 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human -DTXSID7021780 Vd NA 1.159 L/kg 1compartment NA NA Rat Human +DTXSID7021780 Vd NA 1.168 L/kg 1compartment NA NA Rat Human DTXSID7021780 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021780 TK.Half.Life NA 0.7593 hours 1compartment NA NA Rat Human -DTXSID7021780 Css NA 0.04162 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021780 Css NA 0.2217 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021780 Css NA 0.02726 mg/L PBTK NA 50% Rat Human -DTXSID7021780 Css NA 0.139 mg/L PBTK NA 95% Rat Human -DTXSID7021784 Clint NA 14.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021784 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021784 Vd NA 1.035 L/kg 1compartment NA NA Human Human -DTXSID7021784 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7021784 TK.Half.Life NA 11.47 hours 1compartment NA NA Human Human -DTXSID7021784 Css NA 1.848 mg/L 3compartmentss NA 50% Human Human -DTXSID7021784 Css NA 16.84 mg/L 3compartmentss NA 95% Human Human -DTXSID7021784 Css NA 1.136 mg/L PBTK NA 50% Human Human -DTXSID7021784 Css NA 9.982 mg/L PBTK NA 95% Human Human -DTXSID7021784 Clint NA 14.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021784 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021784 Vd NA 0.7708 L/kg 1compartment NA NA Rat Human +DTXSID7021780 TK.Half.Life NA 0.7652 hours 1compartment NA NA Rat Human +DTXSID7021780 Css NA 0.009177 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021780 Css NA 0.05138 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021780 Css NA 0.006222 mg/L PBTK NA 50% Rat Human +DTXSID7021780 Css NA 0.03344 mg/L PBTK NA 95% Rat Human +DTXSID7021782 Clint NA 0.9396 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7021782 Fup NA 0.0236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7021782 Vd NA 3.096 L/kg 1compartment NA NA Human Human +DTXSID7021782 Days.Css NA 440 Days PBTK NA NA Human Human +DTXSID7021782 TK.Half.Life NA 1690 hours 1compartment NA NA Human Human +DTXSID7021782 Css NA 58.51 mg/L 3compartmentss NA 50% Human Human +DTXSID7021782 Css NA 326.1 mg/L 3compartmentss NA 95% Human Human +DTXSID7021782 Css NA 40.65 mg/L PBTK NA 50% Human Human +DTXSID7021782 Css NA 218.9 mg/L PBTK NA 95% Human Human +DTXSID7021782 Clint NA 0.9396 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7021782 Fup NA 0.0236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7021782 Vd NA 2.319 L/kg 1compartment NA NA Rat Human +DTXSID7021782 Days.Css NA 225 Days PBTK NA NA Rat Human +DTXSID7021782 TK.Half.Life NA 216.8 hours 1compartment NA NA Rat Human +DTXSID7021782 Css NA 2.092 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021782 Css NA 13.31 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021782 Css NA 1.403 mg/L PBTK NA 50% Rat Human +DTXSID7021782 Css NA 8.635 mg/L PBTK NA 95% Rat Human +DTXSID7021784 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021784 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021784 Vd NA 1.496 L/kg 1compartment NA NA Human Human +DTXSID7021784 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7021784 TK.Half.Life NA 9.923 hours 1compartment NA NA Human Human +DTXSID7021784 Css NA 0.979 mg/L 3compartmentss NA 50% Human Human +DTXSID7021784 Css NA 8.354 mg/L 3compartmentss NA 95% Human Human +DTXSID7021784 Css NA 0.6158 mg/L PBTK NA 50% Human Human +DTXSID7021784 Css NA 5.175 mg/L PBTK NA 95% Human Human +DTXSID7021784 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021784 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021784 Vd NA 1.116 L/kg 1compartment NA NA Rat Human DTXSID7021784 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021784 TK.Half.Life NA 4.976 hours 1compartment NA NA Rat Human -DTXSID7021784 Css NA 1.032 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021784 Css NA 7.39 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021784 Css NA 0.5897 mg/L PBTK NA 50% Rat Human -DTXSID7021784 Css NA 4.059 mg/L PBTK NA 95% Rat Human -DTXSID7021788 Clint NA 0.1135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021788 Fup NA 0.0745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021788 Vd NA 0.2741 L/kg 1compartment NA NA Human Human -DTXSID7021788 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7021788 TK.Half.Life NA 20.06 hours 1compartment NA NA Human Human -DTXSID7021788 Css NA 11.51 mg/L 3compartmentss NA 50% Human Human -DTXSID7021788 Css NA 52.95 mg/L 3compartmentss NA 95% Human Human -DTXSID7021788 Css NA 7.007 mg/L PBTK NA 50% Human Human -DTXSID7021788 Css NA 30.9 mg/L PBTK NA 95% Human Human -DTXSID7021788 Clint NA 0.1135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021788 Fup NA 0.0745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021788 Vd NA 0.2644 L/kg 1compartment NA NA Rat Human +DTXSID7021784 TK.Half.Life NA 3.83 hours 1compartment NA NA Rat Human +DTXSID7021784 Css NA 0.1296 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021784 Css NA 0.8842 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021784 Css NA 0.07932 mg/L PBTK NA 50% Rat Human +DTXSID7021784 Css NA 0.5256 mg/L PBTK NA 95% Rat Human +DTXSID7021788 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021788 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021788 Vd NA 0.3872 L/kg 1compartment NA NA Human Human +DTXSID7021788 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7021788 TK.Half.Life NA 22.51 hours 1compartment NA NA Human Human +DTXSID7021788 Css NA 8.421 mg/L 3compartmentss NA 50% Human Human +DTXSID7021788 Css NA 39.45 mg/L 3compartmentss NA 95% Human Human +DTXSID7021788 Css NA 5.405 mg/L PBTK NA 50% Human Human +DTXSID7021788 Css NA 23.61 mg/L PBTK NA 95% Human Human +DTXSID7021788 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021788 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021788 Vd NA 0.362 L/kg 1compartment NA NA Rat Human DTXSID7021788 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021788 TK.Half.Life NA 7.17 hours 1compartment NA NA Rat Human -DTXSID7021788 Css NA 3.639 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021788 Css NA 14.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021788 Css NA 2.077 mg/L PBTK NA 50% Rat Human -DTXSID7021788 Css NA 7.787 mg/L PBTK NA 95% Rat Human -DTXSID7021815 Clint NA 2.331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021815 Fup NA 0.171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021815 Vd NA 1.841 L/kg 1compartment NA NA Human Human -DTXSID7021815 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7021815 TK.Half.Life NA 21.17 hours 1compartment NA NA Human Human -DTXSID7021815 Css NA 1.338 mg/L 3compartmentss NA 50% Human Human -DTXSID7021815 Css NA 5.982 mg/L 3compartmentss NA 95% Human Human -DTXSID7021815 Css NA 0.9588 mg/L PBTK NA 50% Human Human -DTXSID7021815 Css NA 3.906 mg/L PBTK NA 95% Human Human -DTXSID7021815 Clint NA 2.331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021815 Fup NA 0.171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021815 Vd NA 1.42 L/kg 1compartment NA NA Rat Human +DTXSID7021788 TK.Half.Life NA 7.138 hours 1compartment NA NA Rat Human +DTXSID7021788 Css NA 0.552 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021788 Css NA 2.152 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021788 Css NA 0.3422 mg/L PBTK NA 50% Rat Human +DTXSID7021788 Css NA 1.238 mg/L PBTK NA 95% Rat Human +DTXSID7021815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021815 Fup 0.0774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021815 Vd NA 1.298 L/kg 1compartment NA NA Human Human +DTXSID7021815 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7021815 TK.Half.Life NA 4.258 hours 1compartment NA NA Human Human +DTXSID7021815 Css NA 0.3879 mg/L 3compartmentss NA 50% Human Human +DTXSID7021815 Css NA 2.837 mg/L 3compartmentss NA 95% Human Human +DTXSID7021815 Css NA 0.2524 mg/L PBTK NA 50% Human Human +DTXSID7021815 Css NA 1.768 mg/L PBTK NA 95% Human Human +DTXSID7021815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021815 Fup 0.0774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021815 Vd NA 0.9921 L/kg 1compartment NA NA Rat Human DTXSID7021815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021815 TK.Half.Life NA 6.762 hours 1compartment NA NA Rat Human -DTXSID7021815 Css NA 0.6209 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021815 Css NA 1.957 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021815 Css NA 0.4252 mg/L PBTK NA 50% Rat Human -DTXSID7021815 Css NA 1.219 mg/L PBTK NA 95% Rat Human -DTXSID7021817 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021817 Fup NA 0.7556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021817 Vd NA 2.124 L/kg 1compartment NA NA Human Human -DTXSID7021817 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7021817 TK.Half.Life NA 28.44 hours 1compartment NA NA Human Human -DTXSID7021817 Css NA 1.291 mg/L 3compartmentss NA 50% Human Human -DTXSID7021817 Css NA 7.05 mg/L 3compartmentss NA 95% Human Human -DTXSID7021817 Css NA 1.183 mg/L PBTK NA 50% Human Human -DTXSID7021817 Css NA 4.829 mg/L PBTK NA 95% Human Human -DTXSID7021817 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021817 Fup NA 0.7556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021817 Vd NA 1.757 L/kg 1compartment NA NA Rat Human +DTXSID7021815 TK.Half.Life NA 1.735 hours 1compartment NA NA Rat Human +DTXSID7021815 Css NA 0.05042 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021815 Css NA 0.2958 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021815 Css NA 0.03177 mg/L PBTK NA 50% Rat Human +DTXSID7021815 Css NA 0.1792 mg/L PBTK NA 95% Rat Human +DTXSID7021817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021817 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021817 Vd NA 1.484 L/kg 1compartment NA NA Human Human +DTXSID7021817 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7021817 TK.Half.Life NA 1.506 hours 1compartment NA NA Human Human +DTXSID7021817 Css NA 0.03346 mg/L 3compartmentss NA 50% Human Human +DTXSID7021817 Css NA 0.3157 mg/L 3compartmentss NA 95% Human Human +DTXSID7021817 Css NA 0.02775 mg/L PBTK NA 50% Human Human +DTXSID7021817 Css NA 0.2278 mg/L PBTK NA 95% Human Human +DTXSID7021817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021817 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021817 Vd NA 1.256 L/kg 1compartment NA NA Rat Human DTXSID7021817 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021817 TK.Half.Life NA 5.815 hours 1compartment NA NA Rat Human -DTXSID7021817 Css NA 0.3426 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021817 Css NA 1.742 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021817 Css NA 0.305 mg/L PBTK NA 50% Rat Human -DTXSID7021817 Css NA 1.108 mg/L PBTK NA 95% Rat Human -DTXSID7021861 Clint NA 2.874 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021861 Fup NA 0.4769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021861 Vd NA 1.951 L/kg 1compartment NA NA Human Human +DTXSID7021817 TK.Half.Life NA 0.615 hours 1compartment NA NA Rat Human +DTXSID7021817 Css NA 0.00117 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021817 Css NA 0.01292 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021817 Css NA 0.0009634 mg/L PBTK NA 50% Rat Human +DTXSID7021817 Css NA 0.009111 mg/L PBTK NA 95% Rat Human +DTXSID7021861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021861 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021861 Vd NA 1.828 L/kg 1compartment NA NA Human Human DTXSID7021861 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021861 TK.Half.Life NA 7.346 hours 1compartment NA NA Human Human -DTXSID7021861 Css NA 0.3572 mg/L 3compartmentss NA 50% Human Human -DTXSID7021861 Css NA 1.941 mg/L 3compartmentss NA 95% Human Human -DTXSID7021861 Css NA 0.2955 mg/L PBTK NA 50% Human Human -DTXSID7021861 Css NA 1.37 mg/L PBTK NA 95% Human Human -DTXSID7021861 Clint NA 2.874 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021861 Fup NA 0.4769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021861 Vd NA 1.586 L/kg 1compartment NA NA Rat Human +DTXSID7021861 TK.Half.Life NA 2.382 hours 1compartment NA NA Human Human +DTXSID7021861 Css NA 0.06965 mg/L 3compartmentss NA 50% Human Human +DTXSID7021861 Css NA 0.5068 mg/L 3compartmentss NA 95% Human Human +DTXSID7021861 Css NA 0.05429 mg/L PBTK NA 50% Human Human +DTXSID7021861 Css NA 0.3573 mg/L PBTK NA 95% Human Human +DTXSID7021861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021861 Fup 0.362 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021861 Vd NA 1.47 L/kg 1compartment NA NA Rat Human DTXSID7021861 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021861 TK.Half.Life NA 2.564 hours 1compartment NA NA Rat Human -DTXSID7021861 Css NA 0.1648 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021861 Css NA 0.7394 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021861 Css NA 0.1336 mg/L PBTK NA 50% Rat Human -DTXSID7021861 Css NA 0.4832 mg/L PBTK NA 95% Rat Human -DTXSID7021863 Clint NA 5.022 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021863 Fup NA 0.7832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021863 Vd NA 1.161 L/kg 1compartment NA NA Human Human +DTXSID7021861 TK.Half.Life NA 0.8883 hours 1compartment NA NA Rat Human +DTXSID7021861 Css NA 0.00857 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021861 Css NA 0.04691 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021861 Css NA 0.00681 mg/L PBTK NA 50% Rat Human +DTXSID7021861 Css NA 0.03379 mg/L PBTK NA 95% Rat Human +DTXSID7021863 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021863 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021863 Vd NA 0.9636 L/kg 1compartment NA NA Human Human DTXSID7021863 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021863 TK.Half.Life NA 1.591 hours 1compartment NA NA Human Human -DTXSID7021863 Css NA 0.1088 mg/L 3compartmentss NA 50% Human Human -DTXSID7021863 Css NA 0.9157 mg/L 3compartmentss NA 95% Human Human -DTXSID7021863 Css NA 0.09496 mg/L PBTK NA 50% Human Human -DTXSID7021863 Css NA 0.6222 mg/L PBTK NA 95% Human Human -DTXSID7021863 Clint NA 5.022 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021863 Fup NA 0.7832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021863 Vd NA 1.091 L/kg 1compartment NA NA Rat Human +DTXSID7021863 TK.Half.Life NA 0.8784 hours 1compartment NA NA Human Human +DTXSID7021863 Css NA 0.03384 mg/L 3compartmentss NA 50% Human Human +DTXSID7021863 Css NA 0.3668 mg/L 3compartmentss NA 95% Human Human +DTXSID7021863 Css NA 0.02797 mg/L PBTK NA 50% Human Human +DTXSID7021863 Css NA 0.2523 mg/L PBTK NA 95% Human Human +DTXSID7021863 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021863 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021863 Vd NA 0.9027 L/kg 1compartment NA NA Rat Human DTXSID7021863 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021863 TK.Half.Life NA 0.7819 hours 1compartment NA NA Rat Human -DTXSID7021863 Css NA 0.04975 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021863 Css NA 0.3912 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021863 Css NA 0.04336 mg/L PBTK NA 50% Rat Human -DTXSID7021863 Css NA 0.2472 mg/L PBTK NA 95% Rat Human -DTXSID7021867 Clint NA 6.885 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021867 Fup NA 0.3744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021867 Vd NA 1.853 L/kg 1compartment NA NA Human Human +DTXSID7021863 TK.Half.Life NA 0.4082 hours 1compartment NA NA Rat Human +DTXSID7021863 Css NA 0.004093 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021863 Css NA 0.03875 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021863 Css NA 0.003401 mg/L PBTK NA 50% Rat Human +DTXSID7021863 Css NA 0.02569 mg/L PBTK NA 95% Rat Human +DTXSID7021865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021865 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021865 Vd NA 2.846 L/kg 1compartment NA NA Human Human +DTXSID7021865 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7021865 TK.Half.Life NA 9.608 hours 1compartment NA NA Human Human +DTXSID7021865 Css NA 0.3079 mg/L 3compartmentss NA 50% Human Human +DTXSID7021865 Css NA 1.928 mg/L 3compartmentss NA 95% Human Human +DTXSID7021865 Css NA 0.2234 mg/L PBTK NA 50% Human Human +DTXSID7021865 Css NA 1.346 mg/L PBTK NA 95% Human Human +DTXSID7021865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021865 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021865 Vd NA 2.159 L/kg 1compartment NA NA Rat Human +DTXSID7021865 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7021865 TK.Half.Life NA 2.132 hours 1compartment NA NA Rat Human +DTXSID7021865 Css NA 0.03888 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021865 Css NA 0.187 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021865 Css NA 0.0282 mg/L PBTK NA 50% Rat Human +DTXSID7021865 Css NA 0.1326 mg/L PBTK NA 95% Rat Human +DTXSID7021867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021867 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021867 Vd NA 1.098 L/kg 1compartment NA NA Human Human DTXSID7021867 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021867 TK.Half.Life NA 4.624 hours 1compartment NA NA Human Human -DTXSID7021867 Css NA 0.2166 mg/L 3compartmentss NA 50% Human Human -DTXSID7021867 Css NA 1.27 mg/L 3compartmentss NA 95% Human Human -DTXSID7021867 Css NA 0.1703 mg/L PBTK NA 50% Human Human -DTXSID7021867 Css NA 0.902 mg/L PBTK NA 95% Human Human -DTXSID7021867 Clint NA 6.885 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021867 Fup NA 0.3744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021867 Vd NA 1.484 L/kg 1compartment NA NA Rat Human +DTXSID7021867 TK.Half.Life NA 2.492 hours 1compartment NA NA Human Human +DTXSID7021867 Css NA 0.2174 mg/L 3compartmentss NA 50% Human Human +DTXSID7021867 Css NA 1.794 mg/L 3compartmentss NA 95% Human Human +DTXSID7021867 Css NA 0.1448 mg/L PBTK NA 50% Human Human +DTXSID7021867 Css NA 1.135 mg/L PBTK NA 95% Human Human +DTXSID7021867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021867 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021867 Vd NA 0.8679 L/kg 1compartment NA NA Rat Human DTXSID7021867 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021867 TK.Half.Life NA 1.702 hours 1compartment NA NA Rat Human -DTXSID7021867 Css NA 0.1084 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021867 Css NA 0.4928 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021867 Css NA 0.08288 mg/L PBTK NA 50% Rat Human -DTXSID7021867 Css NA 0.3321 mg/L PBTK NA 95% Rat Human +DTXSID7021867 TK.Half.Life NA 1.066 hours 1compartment NA NA Rat Human +DTXSID7021867 Css NA 0.02814 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021867 Css NA 0.1745 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021867 Css NA 0.01826 mg/L PBTK NA 50% Rat Human +DTXSID7021867 Css NA 0.106 mg/L PBTK NA 95% Rat Human DTXSID7021869 Clint 39.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7021869 Fup 0.3259 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7021869 Vd NA 1.808 L/kg 1compartment NA NA Human Human DTXSID7021869 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7021869 TK.Half.Life NA 1.578 hours 1compartment NA NA Human Human -DTXSID7021869 Css NA 0.03124 mg/L 3compartmentss NA 50% Human Human -DTXSID7021869 Css NA 0.2427 mg/L 3compartmentss NA 95% Human Human -DTXSID7021869 Css NA 0.03017 mg/L PBTK NA 50% Human Human -DTXSID7021869 Css NA 0.2013 mg/L PBTK NA 95% Human Human +DTXSID7021869 Css NA 0.02292 mg/L 3compartmentss NA 50% Human Human +DTXSID7021869 Css NA 0.201 mg/L 3compartmentss NA 95% Human Human +DTXSID7021869 Css NA 0.02223 mg/L PBTK NA 50% Human Human +DTXSID7021869 Css NA 0.1673 mg/L PBTK NA 95% Human Human DTXSID7021869 Clint 39.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7021869 Fup 0.3259 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7021869 Vd NA 1.616 L/kg 1compartment NA NA Rat Human DTXSID7021869 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7021869 TK.Half.Life NA 0.6925 hours 1compartment NA NA Rat Human -DTXSID7021869 Css NA 0.01644 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021869 Css NA 0.1036 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021869 Css NA 0.0158 mg/L PBTK NA 50% Rat Human -DTXSID7021869 Css NA 0.08343 mg/L PBTK NA 95% Rat Human -DTXSID7021940 Clint NA 5.366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7021869 Css NA 0.0007821 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021869 Css NA 0.008501 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021869 Css NA 0.0007678 mg/L PBTK NA 50% Rat Human +DTXSID7021869 Css NA 0.006953 mg/L PBTK NA 95% Rat Human +DTXSID7021940 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7021940 Fup 0.647 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7021940 Vd NA 2.938 L/kg 1compartment NA NA Human Human -DTXSID7021940 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7021940 TK.Half.Life NA 15.43 hours 1compartment NA NA Human Human -DTXSID7021940 Css NA 0.5095 mg/L 3compartmentss NA 50% Human Human -DTXSID7021940 Css NA 2.492 mg/L 3compartmentss NA 95% Human Human -DTXSID7021940 Css NA 0.401 mg/L PBTK NA 50% Human Human -DTXSID7021940 Css NA 1.857 mg/L PBTK NA 95% Human Human -DTXSID7021940 Clint NA 5.366 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7021940 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7021940 TK.Half.Life NA 5.594 hours 1compartment NA NA Human Human +DTXSID7021940 Css NA 0.13 mg/L 3compartmentss NA 50% Human Human +DTXSID7021940 Css NA 0.8192 mg/L 3compartmentss NA 95% Human Human +DTXSID7021940 Css NA 0.1011 mg/L PBTK NA 50% Human Human +DTXSID7021940 Css NA 0.6097 mg/L PBTK NA 95% Human Human +DTXSID7021940 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7021940 Fup 0.647 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7021940 Vd NA 2.262 L/kg 1compartment NA NA Rat Human DTXSID7021940 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021940 TK.Half.Life NA 3.018 hours 1compartment NA NA Rat Human -DTXSID7021940 Css NA 0.2606 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021940 Css NA 0.9295 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021940 Css NA 0.1978 mg/L PBTK NA 50% Rat Human -DTXSID7021940 Css NA 0.6544 mg/L PBTK NA 95% Rat Human +DTXSID7021940 TK.Half.Life NA 1.332 hours 1compartment NA NA Rat Human +DTXSID7021940 Css NA 0.01612 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021940 Css NA 0.07776 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021940 Css NA 0.0127 mg/L PBTK NA 50% Rat Human +DTXSID7021940 Css NA 0.05743 mg/L PBTK NA 95% Rat Human DTXSID7021948 Clint 6.899 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7021948 Fup 0.2159 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7021948 Vd NA 0.4528 L/kg 1compartment NA NA Human Human DTXSID7021948 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7021948 TK.Half.Life NA 1.413 hours 1compartment NA NA Human Human -DTXSID7021948 Css NA 0.315 mg/L 3compartmentss NA 50% Human Human -DTXSID7021948 Css NA 1.824 mg/L 3compartmentss NA 95% Human Human -DTXSID7021948 Css NA 0.2089 mg/L PBTK NA 50% Human Human -DTXSID7021948 Css NA 1.14 mg/L PBTK NA 95% Human Human +DTXSID7021948 Css NA 0.3059 mg/L 3compartmentss NA 50% Human Human +DTXSID7021948 Css NA 1.815 mg/L 3compartmentss NA 95% Human Human +DTXSID7021948 Css NA 0.2017 mg/L PBTK NA 50% Human Human +DTXSID7021948 Css NA 1.143 mg/L PBTK NA 95% Human Human DTXSID7021948 Clint 6.899 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7021948 Fup 0.2159 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7021948 Vd NA 0.4193 L/kg 1compartment NA NA Rat Human DTXSID7021948 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7021948 TK.Half.Life NA 0.7594 hours 1compartment NA NA Rat Human -DTXSID7021948 Css NA 0.1638 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021948 Css NA 0.7121 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021948 Css NA 0.1032 mg/L PBTK NA 50% Rat Human -DTXSID7021948 Css NA 0.4192 mg/L PBTK NA 95% Rat Human +DTXSID7021948 Css NA 0.03701 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021948 Css NA 0.1614 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021948 Css NA 0.02398 mg/L PBTK NA 50% Rat Human +DTXSID7021948 Css NA 0.09868 mg/L PBTK NA 95% Rat Human DTXSID7021992 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7021992 Fup 0.698 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7021992 Vd NA 0.5314 L/kg 1compartment NA NA Human Human +DTXSID7021992 Vd NA 0.8082 L/kg 1compartment NA NA Human Human DTXSID7021992 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021992 TK.Half.Life NA 4.926 hours 1compartment NA NA Human Human -DTXSID7021992 Css NA 0.6961 mg/L 3compartmentss NA 50% Human Human -DTXSID7021992 Css NA 2.615 mg/L 3compartmentss NA 95% Human Human -DTXSID7021992 Css NA 0.5476 mg/L PBTK NA 50% Human Human -DTXSID7021992 Css NA 1.826 mg/L PBTK NA 95% Human Human +DTXSID7021992 TK.Half.Life NA 7.491 hours 1compartment NA NA Human Human +DTXSID7021992 Css NA 0.5902 mg/L 3compartmentss NA 50% Human Human +DTXSID7021992 Css NA 2.414 mg/L 3compartmentss NA 95% Human Human +DTXSID7021992 Css NA 0.5276 mg/L PBTK NA 50% Human Human +DTXSID7021992 Css NA 1.822 mg/L PBTK NA 95% Human Human DTXSID7021992 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7021992 Fup 0.698 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7021992 Vd NA 0.5392 L/kg 1compartment NA NA Rat Human +DTXSID7021992 Vd NA 0.8249 L/kg 1compartment NA NA Rat Human DTXSID7021992 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021992 TK.Half.Life NA 1.703 hours 1compartment NA NA Rat Human -DTXSID7021992 Css NA 0.2156 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021992 Css NA 0.6395 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021992 Css NA 0.1673 mg/L PBTK NA 50% Rat Human -DTXSID7021992 Css NA 0.411 mg/L PBTK NA 95% Rat Human -DTXSID7021994 Clint NA 26.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021994 Fup NA 0.049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021994 Vd NA 1.575 L/kg 1compartment NA NA Human Human +DTXSID7021992 TK.Half.Life NA 2.606 hours 1compartment NA NA Rat Human +DTXSID7021992 Css NA 0.04203 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021992 Css NA 0.1286 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021992 Css NA 0.03868 mg/L PBTK NA 50% Rat Human +DTXSID7021992 Css NA 0.09293 mg/L PBTK NA 95% Rat Human +DTXSID7021994 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021994 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021994 Vd NA 1.48 L/kg 1compartment NA NA Human Human DTXSID7021994 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021994 TK.Half.Life NA 6.454 hours 1compartment NA NA Human Human -DTXSID7021994 Css NA 0.5446 mg/L 3compartmentss NA 50% Human Human -DTXSID7021994 Css NA 4.175 mg/L 3compartmentss NA 95% Human Human -DTXSID7021994 Css NA 0.3508 mg/L PBTK NA 50% Human Human -DTXSID7021994 Css NA 2.55 mg/L PBTK NA 95% Human Human -DTXSID7021994 Clint NA 26.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021994 Fup NA 0.049 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021994 Vd NA 1.182 L/kg 1compartment NA NA Rat Human +DTXSID7021994 TK.Half.Life NA 8.24 hours 1compartment NA NA Human Human +DTXSID7021994 Css NA 0.798 mg/L 3compartmentss NA 50% Human Human +DTXSID7021994 Css NA 7.219 mg/L 3compartmentss NA 95% Human Human +DTXSID7021994 Css NA 0.5033 mg/L PBTK NA 50% Human Human +DTXSID7021994 Css NA 4.329 mg/L PBTK NA 95% Human Human +DTXSID7021994 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021994 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021994 Vd NA 1.108 L/kg 1compartment NA NA Rat Human DTXSID7021994 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021994 TK.Half.Life NA 2.429 hours 1compartment NA NA Rat Human -DTXSID7021994 Css NA 0.3056 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021994 Css NA 1.896 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021994 Css NA 0.1844 mg/L PBTK NA 50% Rat Human -DTXSID7021994 Css NA 1.095 mg/L PBTK NA 95% Rat Human +DTXSID7021994 TK.Half.Life NA 3.194 hours 1compartment NA NA Rat Human +DTXSID7021994 Css NA 0.1043 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021994 Css NA 0.7136 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021994 Css NA 0.06418 mg/L PBTK NA 50% Rat Human +DTXSID7021994 Css NA 0.4217 mg/L PBTK NA 95% Rat Human DTXSID7021996 Clint NA 0.003459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7021996 Fup NA 0.4002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021996 Vd NA 0.3813 L/kg 1compartment NA NA Human Human +DTXSID7021996 Vd NA 0.3467 L/kg 1compartment NA NA Human Human DTXSID7021996 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7021996 TK.Half.Life NA 6.129 hours 1compartment NA NA Human Human -DTXSID7021996 Css NA 1.899 mg/L 3compartmentss NA 50% Human Human -DTXSID7021996 Css NA 8.338 mg/L 3compartmentss NA 95% Human Human -DTXSID7021996 Css NA 1.327 mg/L PBTK NA 50% Human Human -DTXSID7021996 Css NA 5.13 mg/L PBTK NA 95% Human Human +DTXSID7021996 TK.Half.Life NA 5.572 hours 1compartment NA NA Human Human +DTXSID7021996 Css NA 1.646 mg/L 3compartmentss NA 50% Human Human +DTXSID7021996 Css NA 7.204 mg/L 3compartmentss NA 95% Human Human +DTXSID7021996 Css NA 1.127 mg/L PBTK NA 50% Human Human +DTXSID7021996 Css NA 4.456 mg/L PBTK NA 95% Human Human DTXSID7021996 Clint NA 0.003459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7021996 Fup NA 0.4002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021996 Vd NA 0.3893 L/kg 1compartment NA NA Rat Human +DTXSID7021996 Vd NA 0.3588 L/kg 1compartment NA NA Rat Human DTXSID7021996 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021996 TK.Half.Life NA 2.138 hours 1compartment NA NA Rat Human -DTXSID7021996 Css NA 0.5312 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021996 Css NA 1.951 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021996 Css NA 0.3502 mg/L PBTK NA 50% Rat Human -DTXSID7021996 Css NA 1.126 mg/L PBTK NA 95% Rat Human -DTXSID7021998 Clint NA 3.274 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021998 Fup NA 0.1515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7021998 Vd NA 1.419 L/kg 1compartment NA NA Human Human -DTXSID7021998 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7021998 TK.Half.Life NA 11.93 hours 1compartment NA NA Human Human -DTXSID7021998 Css NA 1.073 mg/L 3compartmentss NA 50% Human Human -DTXSID7021998 Css NA 6.279 mg/L 3compartmentss NA 95% Human Human -DTXSID7021998 Css NA 0.7393 mg/L PBTK NA 50% Human Human -DTXSID7021998 Css NA 4.003 mg/L PBTK NA 95% Human Human -DTXSID7021998 Clint NA 3.274 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021998 Fup NA 0.1515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7021998 Vd NA 1.108 L/kg 1compartment NA NA Rat Human +DTXSID7021996 TK.Half.Life NA 1.971 hours 1compartment NA NA Rat Human +DTXSID7021996 Css NA 0.0301 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021996 Css NA 0.1896 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021996 Css NA 0.01985 mg/L PBTK NA 50% Rat Human +DTXSID7021996 Css NA 0.1147 mg/L PBTK NA 95% Rat Human +DTXSID7021998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021998 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7021998 Vd NA 2.878 L/kg 1compartment NA NA Human Human +DTXSID7021998 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7021998 TK.Half.Life NA 10.74 hours 1compartment NA NA Human Human +DTXSID7021998 Css NA 0.346 mg/L 3compartmentss NA 50% Human Human +DTXSID7021998 Css NA 2.233 mg/L 3compartmentss NA 95% Human Human +DTXSID7021998 Css NA 0.2507 mg/L PBTK NA 50% Human Human +DTXSID7021998 Css NA 1.548 mg/L PBTK NA 95% Human Human +DTXSID7021998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021998 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7021998 Vd NA 2.18 L/kg 1compartment NA NA Rat Human DTXSID7021998 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7021998 TK.Half.Life NA 4.569 hours 1compartment NA NA Rat Human -DTXSID7021998 Css NA 0.5374 mg/L 3compartmentss NA 50% Rat Human -DTXSID7021998 Css NA 2.286 mg/L 3compartmentss NA 95% Rat Human -DTXSID7021998 Css NA 0.35 mg/L PBTK NA 50% Rat Human -DTXSID7021998 Css NA 1.342 mg/L PBTK NA 95% Rat Human +DTXSID7021998 TK.Half.Life NA 2.292 hours 1compartment NA NA Rat Human +DTXSID7021998 Css NA 0.04388 mg/L 3compartmentss NA 50% Rat Human +DTXSID7021998 Css NA 0.2194 mg/L 3compartmentss NA 95% Rat Human +DTXSID7021998 Css NA 0.0316 mg/L PBTK NA 50% Rat Human +DTXSID7021998 Css NA 0.1531 mg/L PBTK NA 95% Rat Human DTXSID7022043 Clint NA 0.01787 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7022043 Fup NA 0.2771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022043 Vd NA 0.436 L/kg 1compartment NA NA Human Human +DTXSID7022043 Vd NA 0.4341 L/kg 1compartment NA NA Human Human DTXSID7022043 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7022043 TK.Half.Life NA 9.872 hours 1compartment NA NA Human Human -DTXSID7022043 Css NA 2.645 mg/L 3compartmentss NA 50% Human Human -DTXSID7022043 Css NA 10.45 mg/L 3compartmentss NA 95% Human Human -DTXSID7022043 Css NA 1.822 mg/L PBTK NA 50% Human Human -DTXSID7022043 Css NA 6.445 mg/L PBTK NA 95% Human Human +DTXSID7022043 TK.Half.Life NA 9.83 hours 1compartment NA NA Human Human +DTXSID7022043 Css NA 1.424 mg/L 3compartmentss NA 50% Human Human +DTXSID7022043 Css NA 6.163 mg/L 3compartmentss NA 95% Human Human +DTXSID7022043 Css NA 0.9878 mg/L PBTK NA 50% Human Human +DTXSID7022043 Css NA 3.851 mg/L PBTK NA 95% Human Human DTXSID7022043 Clint NA 0.01787 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7022043 Fup NA 0.2771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022043 Vd NA 0.4455 L/kg 1compartment NA NA Rat Human +DTXSID7022043 Vd NA 0.4437 L/kg 1compartment NA NA Rat Human DTXSID7022043 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022043 TK.Half.Life NA 3.492 hours 1compartment NA NA Rat Human -DTXSID7022043 Css NA 0.758 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022043 Css NA 2.441 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022043 Css NA 0.4968 mg/L PBTK NA 50% Rat Human -DTXSID7022043 Css NA 1.417 mg/L PBTK NA 95% Rat Human +DTXSID7022043 TK.Half.Life NA 3.478 hours 1compartment NA NA Rat Human +DTXSID7022043 Css NA 0.007812 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022043 Css NA 0.0333 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022043 Css NA 0.005174 mg/L PBTK NA 50% Rat Human +DTXSID7022043 Css NA 0.01983 mg/L PBTK NA 95% Rat Human DTXSID7022049 Clint 163 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7022049 Fup 0.109 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7022049 Vd NA 1.576 L/kg 1compartment NA NA Human Human DTXSID7022049 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7022049 TK.Half.Life NA 1.712 hours 1compartment NA NA Human Human -DTXSID7022049 Css NA 0.03374 mg/L 3compartmentss NA 50% Human Human -DTXSID7022049 Css NA 0.2249 mg/L 3compartmentss NA 95% Human Human -DTXSID7022049 Css NA 0.02296 mg/L PBTK NA 50% Human Human -DTXSID7022049 Css NA 0.1475 mg/L PBTK NA 95% Human Human +DTXSID7022049 Css NA 0.0302 mg/L 3compartmentss NA 50% Human Human +DTXSID7022049 Css NA 0.2203 mg/L 3compartmentss NA 95% Human Human +DTXSID7022049 Css NA 0.02054 mg/L PBTK NA 50% Human Human +DTXSID7022049 Css NA 0.1452 mg/L PBTK NA 95% Human Human DTXSID7022049 Clint 163 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7022049 Fup 0.109 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7022049 Vd NA 1.206 L/kg 1compartment NA NA Rat Human DTXSID7022049 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7022049 TK.Half.Life NA 0.6012 hours 1compartment NA NA Rat Human -DTXSID7022049 Css NA 0.01889 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022049 Css NA 0.09945 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022049 Css NA 0.0122 mg/L PBTK NA 50% Rat Human -DTXSID7022049 Css NA 0.06398 mg/L PBTK NA 95% Rat Human -DTXSID7022120 Clint NA 51.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022120 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022120 Vd NA 3.045 L/kg 1compartment NA NA Human Human -DTXSID7022120 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7022120 TK.Half.Life NA 33.49 hours 1compartment NA NA Human Human -DTXSID7022120 Css NA 1.321 mg/L 3compartmentss NA 50% Human Human -DTXSID7022120 Css NA 8.437 mg/L 3compartmentss NA 95% Human Human -DTXSID7022120 Css NA 0.9074 mg/L PBTK NA 50% Human Human -DTXSID7022120 Css NA 5.688 mg/L PBTK NA 95% Human Human -DTXSID7022120 Clint NA 51.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022120 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022120 Vd NA 2.281 L/kg 1compartment NA NA Rat Human -DTXSID7022120 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7022120 TK.Half.Life NA 5.259 hours 1compartment NA NA Rat Human -DTXSID7022120 Css NA 0.7456 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022120 Css NA 4.019 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022120 Css NA 0.4904 mg/L PBTK NA 50% Rat Human -DTXSID7022120 Css NA 2.5 mg/L PBTK NA 95% Rat Human -DTXSID7022124 Clint NA 3.034 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022124 Fup NA 0.5115 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022124 Vd NA 1.249 L/kg 1compartment NA NA Human Human -DTXSID7022124 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022124 TK.Half.Life NA 3.408 hours 1compartment NA NA Human Human -DTXSID7022124 Css NA 0.2453 mg/L 3compartmentss NA 50% Human Human -DTXSID7022124 Css NA 1.673 mg/L 3compartmentss NA 95% Human Human -DTXSID7022124 Css NA 0.2048 mg/L PBTK NA 50% Human Human -DTXSID7022124 Css NA 1.148 mg/L PBTK NA 95% Human Human -DTXSID7022124 Clint NA 3.034 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022124 Fup NA 0.5115 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022124 Vd NA 1.093 L/kg 1compartment NA NA Rat Human -DTXSID7022124 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022124 TK.Half.Life NA 1.529 hours 1compartment NA NA Rat Human -DTXSID7022124 Css NA 0.1144 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022124 Css NA 0.635 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022124 Css NA 0.09242 mg/L PBTK NA 50% Rat Human -DTXSID7022124 Css NA 0.3946 mg/L PBTK NA 95% Rat Human -DTXSID7022128 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022128 Fup NA 0.9053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022128 Vd NA 0.9848 L/kg 1compartment NA NA Human Human +DTXSID7022049 Css NA 0.004023 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022049 Css NA 0.02376 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022049 Css NA 0.002711 mg/L PBTK NA 50% Rat Human +DTXSID7022049 Css NA 0.01536 mg/L PBTK NA 95% Rat Human +DTXSID7022120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022120 Fup 0.0107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022120 Vd NA 3.023 L/kg 1compartment NA NA Human Human +DTXSID7022120 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID7022120 TK.Half.Life NA 75.78 hours 1compartment NA NA Human Human +DTXSID7022120 Css NA 3.097 mg/L 3compartmentss NA 50% Human Human +DTXSID7022120 Css NA 20.33 mg/L 3compartmentss NA 95% Human Human +DTXSID7022120 Css NA 2.13 mg/L PBTK NA 50% Human Human +DTXSID7022120 Css NA 13.78 mg/L PBTK NA 95% Human Human +DTXSID7022120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022120 Fup 0.0107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022120 Vd NA 2.262 L/kg 1compartment NA NA Rat Human +DTXSID7022120 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID7022120 TK.Half.Life NA 11.61 hours 1compartment NA NA Rat Human +DTXSID7022120 Css NA 0.4016 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022120 Css NA 2.375 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022120 Css NA 0.2728 mg/L PBTK NA 50% Rat Human +DTXSID7022120 Css NA 1.579 mg/L PBTK NA 95% Rat Human +DTXSID7022128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022128 Fup 0.897 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022128 Vd NA 0.9786 L/kg 1compartment NA NA Human Human DTXSID7022128 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022128 TK.Half.Life NA 7.161 hours 1compartment NA NA Human Human -DTXSID7022128 Css NA 0.8848 mg/L 3compartmentss NA 50% Human Human -DTXSID7022128 Css NA 5.295 mg/L 3compartmentss NA 95% Human Human -DTXSID7022128 Css NA 0.7682 mg/L PBTK NA 50% Human Human -DTXSID7022128 Css NA 3.516 mg/L PBTK NA 95% Human Human -DTXSID7022128 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022128 Fup NA 0.9053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022128 Vd NA 0.9705 L/kg 1compartment NA NA Rat Human +DTXSID7022128 TK.Half.Life NA 0.7055 hours 1compartment NA NA Human Human +DTXSID7022128 Css NA 0.01842 mg/L 3compartmentss NA 50% Human Human +DTXSID7022128 Css NA 0.2223 mg/L 3compartmentss NA 95% Human Human +DTXSID7022128 Css NA 0.01568 mg/L PBTK NA 50% Human Human +DTXSID7022128 Css NA 0.1579 mg/L PBTK NA 95% Human Human +DTXSID7022128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022128 Fup 0.897 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022128 Vd NA 0.965 L/kg 1compartment NA NA Rat Human DTXSID7022128 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022128 TK.Half.Life NA 2.374 hours 1compartment NA NA Rat Human -DTXSID7022128 Css NA 0.225 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022128 Css NA 1.344 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022128 Css NA 0.1909 mg/L PBTK NA 50% Rat Human -DTXSID7022128 Css NA 0.8223 mg/L PBTK NA 95% Rat Human -DTXSID7022170 Clint NA 12.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022170 Fup NA 0.3116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022170 Vd NA 0.5871 L/kg 1compartment NA NA Human Human +DTXSID7022128 TK.Half.Life NA 0.3339 hours 1compartment NA NA Rat Human +DTXSID7022128 Css NA 0.000659 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022128 Css NA 0.008434 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022128 Css NA 0.0005569 mg/L PBTK NA 50% Rat Human +DTXSID7022128 Css NA 0.00589 mg/L PBTK NA 95% Rat Human +DTXSID7022170 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022170 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022170 Vd NA 0.5677 L/kg 1compartment NA NA Human Human DTXSID7022170 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022170 TK.Half.Life NA 0.962 hours 1compartment NA NA Human Human -DTXSID7022170 Css NA 0.1143 mg/L 3compartmentss NA 50% Human Human -DTXSID7022170 Css NA 0.8008 mg/L 3compartmentss NA 95% Human Human -DTXSID7022170 Css NA 0.08106 mg/L PBTK NA 50% Human Human -DTXSID7022170 Css NA 0.5306 mg/L PBTK NA 95% Human Human -DTXSID7022170 Clint NA 12.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022170 Fup NA 0.3116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022170 Vd NA 0.5603 L/kg 1compartment NA NA Rat Human +DTXSID7022170 TK.Half.Life NA 1.476 hours 1compartment NA NA Human Human +DTXSID7022170 Css NA 0.2325 mg/L 3compartmentss NA 50% Human Human +DTXSID7022170 Css NA 1.43 mg/L 3compartmentss NA 95% Human Human +DTXSID7022170 Css NA 0.1636 mg/L PBTK NA 50% Human Human +DTXSID7022170 Css NA 0.9249 mg/L PBTK NA 95% Human Human +DTXSID7022170 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022170 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022170 Vd NA 0.5417 L/kg 1compartment NA NA Rat Human DTXSID7022170 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022170 TK.Half.Life NA 0.5048 hours 1compartment NA NA Rat Human -DTXSID7022170 Css NA 0.06166 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022170 Css NA 0.3121 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022170 Css NA 0.04157 mg/L PBTK NA 50% Rat Human -DTXSID7022170 Css NA 0.195 mg/L PBTK NA 95% Rat Human -DTXSID7022172 Clint NA 85.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022172 Fup NA 0.1926 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022172 Vd NA 0.9733 L/kg 1compartment NA NA Human Human +DTXSID7022170 TK.Half.Life NA 0.8016 hours 1compartment NA NA Rat Human +DTXSID7022170 Css NA 0.02752 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022170 Css NA 0.1256 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022170 Css NA 0.01906 mg/L PBTK NA 50% Rat Human +DTXSID7022170 Css NA 0.07951 mg/L PBTK NA 95% Rat Human +DTXSID7022172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022172 Fup 0.497 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022172 Vd NA 1.6 L/kg 1compartment NA NA Human Human DTXSID7022172 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022172 TK.Half.Life NA 1.006 hours 1compartment NA NA Human Human -DTXSID7022172 Css NA 0.0311 mg/L 3compartmentss NA 50% Human Human -DTXSID7022172 Css NA 0.2305 mg/L 3compartmentss NA 95% Human Human -DTXSID7022172 Css NA 0.02169 mg/L PBTK NA 50% Human Human -DTXSID7022172 Css NA 0.1524 mg/L PBTK NA 95% Human Human -DTXSID7022172 Clint NA 85.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022172 Fup NA 0.1926 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022172 Vd NA 0.8038 L/kg 1compartment NA NA Rat Human +DTXSID7022172 TK.Half.Life NA 1.652 hours 1compartment NA NA Human Human +DTXSID7022172 Css NA 0.04336 mg/L 3compartmentss NA 50% Human Human +DTXSID7022172 Css NA 0.3839 mg/L 3compartmentss NA 95% Human Human +DTXSID7022172 Css NA 0.03594 mg/L PBTK NA 50% Human Human +DTXSID7022172 Css NA 0.2774 mg/L PBTK NA 95% Human Human +DTXSID7022172 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022172 Fup 0.497 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022172 Vd NA 1.334 L/kg 1compartment NA NA Rat Human DTXSID7022172 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022172 TK.Half.Life NA 0.3993 hours 1compartment NA NA Rat Human -DTXSID7022172 Css NA 0.01727 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022172 Css NA 0.097 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022172 Css NA 0.01151 mg/L PBTK NA 50% Rat Human -DTXSID7022172 Css NA 0.06186 mg/L PBTK NA 95% Rat Human +DTXSID7022172 TK.Half.Life NA 0.6545 hours 1compartment NA NA Rat Human +DTXSID7022172 Css NA 0.005314 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022172 Css NA 0.03622 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022172 Css NA 0.004436 mg/L PBTK NA 50% Rat Human +DTXSID7022172 Css NA 0.02601 mg/L PBTK NA 95% Rat Human DTXSID7022174 Clint 8.16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7022174 Fup 0.01016 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7022174 Vd NA 1.633 L/kg 1compartment NA NA Human Human DTXSID7022174 Days.Css NA 9 Days PBTK NA NA Human Human DTXSID7022174 TK.Half.Life NA 60.96 hours 1compartment NA NA Human Human -DTXSID7022174 Css NA 6.308 mg/L 3compartmentss NA 50% Human Human -DTXSID7022174 Css NA 50.9 mg/L 3compartmentss NA 95% Human Human -DTXSID7022174 Css NA 3.96 mg/L PBTK NA 50% Human Human -DTXSID7022174 Css NA 30.78 mg/L PBTK NA 95% Human Human +DTXSID7022174 Css NA 6.119 mg/L 3compartmentss NA 50% Human Human +DTXSID7022174 Css NA 50.71 mg/L 3compartmentss NA 95% Human Human +DTXSID7022174 Css NA 3.855 mg/L PBTK NA 50% Human Human +DTXSID7022174 Css NA 30.5 mg/L PBTK NA 95% Human Human DTXSID7022174 Clint 8.16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7022174 Fup 0.01016 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7022174 Vd NA 1.205 L/kg 1compartment NA NA Rat Human DTXSID7022174 Days.Css NA 4 Days PBTK NA NA Rat Human DTXSID7022174 TK.Half.Life NA 22.03 hours 1compartment NA NA Rat Human -DTXSID7022174 Css NA 3.466 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022174 Css NA 22.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022174 Css NA 2.04 mg/L PBTK NA 50% Rat Human -DTXSID7022174 Css NA 12.57 mg/L PBTK NA 95% Rat Human +DTXSID7022174 Css NA 0.7798 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022174 Css NA 5.129 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022174 Css NA 0.4758 mg/L PBTK NA 50% Rat Human +DTXSID7022174 Css NA 3.015 mg/L PBTK NA 95% Rat Human DTXSID7022253 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7022253 Fup NA 0.0098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022253 Vd NA 3.857 L/kg 1compartment NA NA Human Human +DTXSID7022253 Fup 0.00832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022253 Vd NA 3.851 L/kg 1compartment NA NA Human Human DTXSID7022253 Days.Css NA 3276 Days PBTK NA NA Human Human DTXSID7022253 TK.Half.Life NA 178400 hours 1compartment NA NA Human Human -DTXSID7022253 Css NA 6203 mg/L 3compartmentss NA 50% Human Human -DTXSID7022253 Css NA 13820 mg/L 3compartmentss NA 95% Human Human -DTXSID7022253 Css NA 3595 mg/L PBTK NA 50% Human Human -DTXSID7022253 Css NA 7856 mg/L PBTK NA 95% Human Human +DTXSID7022253 Css NA 5468 mg/L 3compartmentss NA 50% Human Human +DTXSID7022253 Css NA 11690 mg/L 3compartmentss NA 95% Human Human +DTXSID7022253 Css NA 3520 mg/L PBTK NA 50% Human Human +DTXSID7022253 Css NA 7527 mg/L PBTK NA 95% Human Human DTXSID7022253 Clint 96.48 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID7022253 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID7022253 Css NA 0.5818 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7022253 Css NA 2.492 mg/L 3compartmentss NA 95% Rat Rat +DTXSID7022253 Css 0.00072 0.1106 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID7022253 Css 0.00072 0.5596 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat DTXSID7022332 Clint 19.03 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7022332 Fup 0.0608 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7022332 Vd NA 2.11 L/kg 1compartment NA NA Human Human DTXSID7022332 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7022332 TK.Half.Life NA 9.454 hours 1compartment NA NA Human Human -DTXSID7022332 Css NA 0.4944 mg/L 3compartmentss NA 50% Human Human -DTXSID7022332 Css NA 3.766 mg/L 3compartmentss NA 95% Human Human -DTXSID7022332 Css NA 0.4119 mg/L PBTK NA 50% Human Human -DTXSID7022332 Css NA 2.716 mg/L PBTK NA 95% Human Human +DTXSID7022332 Css NA 0.466 mg/L 3compartmentss NA 50% Human Human +DTXSID7022332 Css NA 3.819 mg/L 3compartmentss NA 95% Human Human +DTXSID7022332 Css NA 0.3932 mg/L PBTK NA 50% Human Human +DTXSID7022332 Css NA 2.754 mg/L PBTK NA 95% Human Human DTXSID7022332 Clint 19.03 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7022332 Fup 0.0608 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7022332 Vd NA 1.759 L/kg 1compartment NA NA Rat Human DTXSID7022332 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7022332 TK.Half.Life NA 3.879 hours 1compartment NA NA Rat Human -DTXSID7022332 Css NA 0.2669 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022332 Css NA 1.613 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022332 Css NA 0.2154 mg/L PBTK NA 50% Rat Human -DTXSID7022332 Css NA 1.118 mg/L PBTK NA 95% Rat Human -DTXSID7022382 Clint NA 62.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022382 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022382 Vd NA 2.337 L/kg 1compartment NA NA Human Human -DTXSID7022382 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022382 TK.Half.Life NA 9.932 hours 1compartment NA NA Human Human -DTXSID7022382 Css NA 0.5304 mg/L 3compartmentss NA 50% Human Human -DTXSID7022382 Css NA 4.233 mg/L 3compartmentss NA 95% Human Human -DTXSID7022382 Css NA 0.349 mg/L PBTK NA 50% Human Human -DTXSID7022382 Css NA 2.64 mg/L PBTK NA 95% Human Human -DTXSID7022382 Clint NA 62.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022382 Fup NA 0.0231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022382 Vd NA 1.742 L/kg 1compartment NA NA Rat Human -DTXSID7022382 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022382 TK.Half.Life NA 2.802 hours 1compartment NA NA Rat Human -DTXSID7022382 Css NA 0.2993 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022382 Css NA 1.927 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022382 Css NA 0.1862 mg/L PBTK NA 50% Rat Human -DTXSID7022382 Css NA 1.138 mg/L PBTK NA 95% Rat Human -DTXSID7022384 Clint NA 49.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022384 Fup NA 0.0135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022384 Vd NA 2.736 L/kg 1compartment NA NA Human Human -DTXSID7022384 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022384 TK.Half.Life NA 5.545 hours 1compartment NA NA Human Human -DTXSID7022384 Css NA 0.1788 mg/L 3compartmentss NA 50% Human Human -DTXSID7022384 Css NA 1.409 mg/L 3compartmentss NA 95% Human Human -DTXSID7022384 Css NA 0.1243 mg/L PBTK NA 50% Human Human -DTXSID7022384 Css NA 0.9212 mg/L PBTK NA 95% Human Human -DTXSID7022384 Clint NA 49.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022384 Fup NA 0.0135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022384 Vd NA 2.137 L/kg 1compartment NA NA Rat Human -DTXSID7022384 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022384 TK.Half.Life NA 1.63 hours 1compartment NA NA Rat Human -DTXSID7022384 Css NA 0.09981 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022384 Css NA 0.6635 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022384 Css NA 0.06626 mg/L PBTK NA 50% Rat Human -DTXSID7022384 Css NA 0.4208 mg/L PBTK NA 95% Rat Human +DTXSID7022332 Css NA 0.05928 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022332 Css NA 0.3676 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022332 Css NA 0.0496 mg/L PBTK NA 50% Rat Human +DTXSID7022332 Css NA 0.2649 mg/L PBTK NA 95% Rat Human +DTXSID7022382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022382 Fup 0.00702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022382 Vd NA 3.087 L/kg 1compartment NA NA Human Human +DTXSID7022382 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID7022382 TK.Half.Life NA 92.47 hours 1compartment NA NA Human Human +DTXSID7022382 Css NA 3.544 mg/L 3compartmentss NA 50% Human Human +DTXSID7022382 Css NA 21.68 mg/L 3compartmentss NA 95% Human Human +DTXSID7022382 Css NA 2.44 mg/L PBTK NA 50% Human Human +DTXSID7022382 Css NA 14.69 mg/L PBTK NA 95% Human Human +DTXSID7022382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022382 Fup 0.00702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022382 Vd NA 2.312 L/kg 1compartment NA NA Rat Human +DTXSID7022382 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID7022382 TK.Half.Life NA 12.99 hours 1compartment NA NA Rat Human +DTXSID7022382 Css NA 0.4682 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022382 Css NA 2.357 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022382 Css NA 0.3202 mg/L PBTK NA 50% Rat Human +DTXSID7022382 Css NA 1.62 mg/L PBTK NA 95% Rat Human +DTXSID7022384 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022384 Fup 0.00912 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022384 Vd NA 3.073 L/kg 1compartment NA NA Human Human +DTXSID7022384 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID7022384 TK.Half.Life NA 86.84 hours 1compartment NA NA Human Human +DTXSID7022384 Css NA 3.407 mg/L 3compartmentss NA 50% Human Human +DTXSID7022384 Css NA 22.53 mg/L 3compartmentss NA 95% Human Human +DTXSID7022384 Css NA 2.358 mg/L PBTK NA 50% Human Human +DTXSID7022384 Css NA 15.05 mg/L PBTK NA 95% Human Human +DTXSID7022384 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022384 Fup 0.00912 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022384 Vd NA 2.302 L/kg 1compartment NA NA Rat Human +DTXSID7022384 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID7022384 TK.Half.Life NA 12.45 hours 1compartment NA NA Rat Human +DTXSID7022384 Css NA 0.446 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022384 Css NA 2.396 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022384 Css NA 0.3044 mg/L PBTK NA 50% Rat Human +DTXSID7022384 Css NA 1.614 mg/L PBTK NA 95% Rat Human DTXSID7022411 Clint NA 272.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7022411 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022411 Vd NA 169.2 L/kg 1compartment NA NA Human Human -DTXSID7022411 Days.Css NA 85 Days PBTK NA NA Human Human -DTXSID7022411 TK.Half.Life NA 406.3 hours 1compartment NA NA Human Human -DTXSID7022411 Css NA 0.009122 mg/L 3compartmentss NA 50% Human Human -DTXSID7022411 Css NA 0.05483 mg/L 3compartmentss NA 95% Human Human -DTXSID7022411 Css NA 0.1989 mg/L PBTK NA 50% Human Human -DTXSID7022411 Css NA 1.081 mg/L PBTK NA 95% Human Human +DTXSID7022411 Vd NA 14.37 L/kg 1compartment NA NA Human Human +DTXSID7022411 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7022411 TK.Half.Life NA 39.16 hours 1compartment NA NA Human Human +DTXSID7022411 Css NA 0.1218 mg/L 3compartmentss NA 50% Human Human +DTXSID7022411 Css NA 0.7679 mg/L 3compartmentss NA 95% Human Human +DTXSID7022411 Css NA 0.1914 mg/L PBTK NA 50% Human Human +DTXSID7022411 Css NA 1.164 mg/L PBTK NA 95% Human Human DTXSID7022411 Clint NA 272.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7022411 Fup NA 0.0055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022411 Vd NA 148.7 L/kg 1compartment NA NA Rat Human -DTXSID7022411 Days.Css NA 59 Days PBTK NA NA Rat Human -DTXSID7022411 TK.Half.Life NA 65.33 hours 1compartment NA NA Rat Human -DTXSID7022411 Css NA 0.004596 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022411 Css NA 0.0204 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022411 Css NA 0.1073 mg/L PBTK NA 50% Rat Human -DTXSID7022411 Css NA 0.4556 mg/L PBTK NA 95% Rat Human +DTXSID7022411 Vd NA 11.5 L/kg 1compartment NA NA Rat Human +DTXSID7022411 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7022411 TK.Half.Life NA 6.684 hours 1compartment NA NA Rat Human +DTXSID7022411 Css NA 0.01517 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022411 Css NA 0.07448 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022411 Css NA 0.02502 mg/L PBTK NA 50% Rat Human +DTXSID7022411 Css NA 0.1284 mg/L PBTK NA 95% Rat Human DTXSID7022413 Clint 71.78 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID7022413 Fup NA 0.1947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022413 Vd NA 2.393 L/kg 1compartment NA NA Human Human +DTXSID7022413 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022413 Vd NA 1.331 L/kg 1compartment NA NA Human Human DTXSID7022413 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022413 TK.Half.Life NA 3.145 hours 1compartment NA NA Human Human -DTXSID7022413 Css NA 0.06668 mg/L 3compartmentss NA 50% Human Human -DTXSID7022413 Css NA 0.438 mg/L 3compartmentss NA 95% Human Human -DTXSID7022413 Css NA 0.04814 mg/L PBTK NA 50% Human Human -DTXSID7022413 Css NA 0.3022 mg/L PBTK NA 95% Human Human +DTXSID7022413 TK.Half.Life NA 2.993 hours 1compartment NA NA Human Human +DTXSID7022413 Css NA 0.238 mg/L 3compartmentss NA 50% Human Human +DTXSID7022413 Css NA 2.127 mg/L 3compartmentss NA 95% Human Human +DTXSID7022413 Css NA 0.1499 mg/L PBTK NA 50% Human Human +DTXSID7022413 Css NA 1.289 mg/L PBTK NA 95% Human Human DTXSID7022413 Clint 71.78 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID7022413 Fup NA 0.1947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022413 Vd NA 1.826 L/kg 1compartment NA NA Rat Human +DTXSID7022413 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022413 Vd 20 0.9995 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID7022413 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022413 TK.Half.Life NA 0.9722 hours 1compartment NA NA Rat Human -DTXSID7022413 Css NA 0.0372 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022413 Css NA 0.2008 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022413 Css NA 0.0259 mg/L PBTK NA 50% Rat Human -DTXSID7022413 Css NA 0.1389 mg/L PBTK NA 95% Rat Human -DTXSID7022417 Clint NA 63.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022417 Fup NA 0.1337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022417 Vd NA 1.918 L/kg 1compartment NA NA Human Human +DTXSID7022413 TK.Half.Life 0.23 1.159 hours 1compartment National Toxicology Program NA Rat Human +DTXSID7022413 Css 0.00069 0.03106 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID7022413 Css 0.00069 0.2366 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID7022413 Css 0.00069 0.019 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID7022413 Css 0.00069 0.1408 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID7022417 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022417 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022417 Vd NA 1.999 L/kg 1compartment NA NA Human Human DTXSID7022417 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022417 TK.Half.Life NA 2.747 hours 1compartment NA NA Human Human -DTXSID7022417 Css NA 0.09318 mg/L 3compartmentss NA 50% Human Human -DTXSID7022417 Css NA 0.6938 mg/L 3compartmentss NA 95% Human Human -DTXSID7022417 Css NA 0.06429 mg/L PBTK NA 50% Human Human -DTXSID7022417 Css NA 0.4455 mg/L PBTK NA 95% Human Human -DTXSID7022417 Clint NA 63.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022417 Fup NA 0.1337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022417 Vd NA 1.465 L/kg 1compartment NA NA Rat Human +DTXSID7022417 TK.Half.Life NA 4.976 hours 1compartment NA NA Human Human +DTXSID7022417 Css NA 0.2298 mg/L 3compartmentss NA 50% Human Human +DTXSID7022417 Css NA 1.642 mg/L 3compartmentss NA 95% Human Human +DTXSID7022417 Css NA 0.1599 mg/L PBTK NA 50% Human Human +DTXSID7022417 Css NA 1.087 mg/L PBTK NA 95% Human Human +DTXSID7022417 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022417 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022417 Vd NA 1.529 L/kg 1compartment NA NA Rat Human DTXSID7022417 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022417 TK.Half.Life NA 0.9411 hours 1compartment NA NA Rat Human -DTXSID7022417 Css NA 0.052 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022417 Css NA 0.2976 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022417 Css NA 0.03418 mg/L PBTK NA 50% Rat Human -DTXSID7022417 Css NA 0.1848 mg/L PBTK NA 95% Rat Human -DTXSID7022540 Clint NA 0.6578 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022540 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022540 Vd NA 1.021 L/kg 1compartment NA NA Human Human -DTXSID7022540 Days.Css NA 82 Days PBTK NA NA Human Human -DTXSID7022540 TK.Half.Life NA 340.3 hours 1compartment NA NA Human Human -DTXSID7022540 Css NA 56.22 mg/L 3compartmentss NA 50% Human Human -DTXSID7022540 Css NA 353.4 mg/L 3compartmentss NA 95% Human Human -DTXSID7022540 Css NA 33.97 mg/L PBTK NA 50% Human Human -DTXSID7022540 Css NA 208 mg/L PBTK NA 95% Human Human -DTXSID7022540 Clint NA 0.6578 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022540 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022540 Vd NA 0.7519 L/kg 1compartment NA NA Rat Human -DTXSID7022540 Days.Css NA 28 Days PBTK NA NA Rat Human -DTXSID7022540 TK.Half.Life NA 110.3 hours 1compartment NA NA Rat Human -DTXSID7022540 Css NA 23.32 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022540 Css NA 128.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022540 Css NA 13.18 mg/L PBTK NA 50% Rat Human -DTXSID7022540 Css NA 69.88 mg/L PBTK NA 95% Rat Human -DTXSID7022544 Clint NA 0.2143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7022417 TK.Half.Life NA 1.678 hours 1compartment NA NA Rat Human +DTXSID7022417 Css NA 0.02958 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022417 Css NA 0.1677 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022417 Css NA 0.02041 mg/L PBTK NA 50% Rat Human +DTXSID7022417 Css NA 0.1093 mg/L PBTK NA 95% Rat Human +DTXSID7022540 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022540 Fup 0.0764 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022540 Vd NA 2.553 L/kg 1compartment NA NA Human Human +DTXSID7022540 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7022540 TK.Half.Life NA 42.79 hours 1compartment NA NA Human Human +DTXSID7022540 Css NA 2.2 mg/L 3compartmentss NA 50% Human Human +DTXSID7022540 Css NA 12.35 mg/L 3compartmentss NA 95% Human Human +DTXSID7022540 Css NA 1.493 mg/L PBTK NA 50% Human Human +DTXSID7022540 Css NA 8.004 mg/L PBTK NA 95% Human Human +DTXSID7022540 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022540 Fup 0.0764 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022540 Vd NA 1.918 L/kg 1compartment NA NA Rat Human +DTXSID7022540 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7022540 TK.Half.Life NA 9.913 hours 1compartment NA NA Rat Human +DTXSID7022540 Css NA 0.2702 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022540 Css NA 1.146 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022540 Css NA 0.1822 mg/L PBTK NA 50% Rat Human +DTXSID7022540 Css NA 0.734 mg/L PBTK NA 95% Rat Human +DTXSID7022544 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7022544 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7022544 Vd NA 0.1857 L/kg 1compartment NA NA Human Human -DTXSID7022544 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7022544 TK.Half.Life NA 22.17 hours 1compartment NA NA Human Human -DTXSID7022544 Css NA 20.73 mg/L 3compartmentss NA 50% Human Human -DTXSID7022544 Css NA 122.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7022544 Css NA 12.12 mg/L PBTK NA 50% Human Human -DTXSID7022544 Css NA 71.07 mg/L PBTK NA 95% Human Human -DTXSID7022544 Clint NA 0.2143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7022544 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID7022544 TK.Half.Life NA 30.03 hours 1compartment NA NA Human Human +DTXSID7022544 Css NA 25.22 mg/L 3compartmentss NA 50% Human Human +DTXSID7022544 Css NA 146 mg/L 3compartmentss NA 95% Human Human +DTXSID7022544 Css NA 14.83 mg/L PBTK NA 50% Human Human +DTXSID7022544 Css NA 84.65 mg/L PBTK NA 95% Human Human +DTXSID7022544 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7022544 Fup 0.04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7022544 Vd NA 0.1855 L/kg 1compartment NA NA Rat Human -DTXSID7022544 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022544 TK.Half.Life NA 8.723 hours 1compartment NA NA Rat Human -DTXSID7022544 Css NA 6.942 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022544 Css NA 34.82 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022544 Css NA 3.806 mg/L PBTK NA 50% Rat Human -DTXSID7022544 Css NA 18.86 mg/L PBTK NA 95% Rat Human +DTXSID7022544 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7022544 TK.Half.Life NA 10.22 hours 1compartment NA NA Rat Human +DTXSID7022544 Css NA 0.753 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022544 Css NA 4.786 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022544 Css NA 0.423 mg/L PBTK NA 50% Rat Human +DTXSID7022544 Css NA 2.67 mg/L PBTK NA 95% Rat Human DTXSID7022546 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7022546 Fup NA 0.8124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022546 Vd NA 0.654 L/kg 1compartment NA NA Human Human +DTXSID7022546 Vd NA 0.6548 L/kg 1compartment NA NA Human Human DTXSID7022546 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022546 TK.Half.Life NA 5.208 hours 1compartment NA NA Human Human -DTXSID7022546 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human -DTXSID7022546 Css NA 5.966 mg/L 3compartmentss NA 95% Human Human -DTXSID7022546 Css NA 0.8076 mg/L PBTK NA 50% Human Human -DTXSID7022546 Css NA 3.806 mg/L PBTK NA 95% Human Human +DTXSID7022546 TK.Half.Life NA 5.216 hours 1compartment NA NA Human Human +DTXSID7022546 Css NA 0.8604 mg/L 3compartmentss NA 50% Human Human +DTXSID7022546 Css NA 5.092 mg/L 3compartmentss NA 95% Human Human +DTXSID7022546 Css NA 0.6934 mg/L PBTK NA 50% Human Human +DTXSID7022546 Css NA 3.22 mg/L PBTK NA 95% Human Human DTXSID7022546 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7022546 Fup NA 0.8124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022546 Vd NA 0.6916 L/kg 1compartment NA NA Rat Human +DTXSID7022546 Vd NA 0.6925 L/kg 1compartment NA NA Rat Human DTXSID7022546 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022546 TK.Half.Life NA 1.877 hours 1compartment NA NA Rat Human -DTXSID7022546 Css NA 0.2565 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022546 Css NA 1.486 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022546 Css NA 0.1998 mg/L PBTK NA 50% Rat Human -DTXSID7022546 Css NA 0.883 mg/L PBTK NA 95% Rat Human -DTXSID7022590 Clint NA 1.219 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022590 Fup NA 0.4815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022590 Vd NA 0.3482 L/kg 1compartment NA NA Human Human +DTXSID7022546 TK.Half.Life NA 1.879 hours 1compartment NA NA Rat Human +DTXSID7022546 Css NA 0.01586 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022546 Css NA 0.1189 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022546 Css NA 0.01225 mg/L PBTK NA 50% Rat Human +DTXSID7022546 Css NA 0.07679 mg/L PBTK NA 95% Rat Human +DTXSID7022590 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022590 Fup 0.672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022590 Vd NA 0.4084 L/kg 1compartment NA NA Human Human DTXSID7022590 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022590 TK.Half.Life NA 1.608 hours 1compartment NA NA Human Human -DTXSID7022590 Css NA 0.5424 mg/L 3compartmentss NA 50% Human Human -DTXSID7022590 Css NA 2.862 mg/L 3compartmentss NA 95% Human Human -DTXSID7022590 Css NA 0.3712 mg/L PBTK NA 50% Human Human -DTXSID7022590 Css NA 1.772 mg/L PBTK NA 95% Human Human -DTXSID7022590 Clint NA 1.219 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022590 Fup NA 0.4815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022590 Vd NA 0.3629 L/kg 1compartment NA NA Rat Human +DTXSID7022590 TK.Half.Life NA 3.932 hours 1compartment NA NA Human Human +DTXSID7022590 Css NA 1.088 mg/L 3compartmentss NA 50% Human Human +DTXSID7022590 Css NA 6.471 mg/L 3compartmentss NA 95% Human Human +DTXSID7022590 Css NA 0.7866 mg/L PBTK NA 50% Human Human +DTXSID7022590 Css NA 4.015 mg/L PBTK NA 95% Human Human +DTXSID7022590 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022590 Fup 0.672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022590 Vd NA 0.4272 L/kg 1compartment NA NA Rat Human DTXSID7022590 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022590 TK.Half.Life NA 0.8439 hours 1compartment NA NA Rat Human -DTXSID7022590 Css NA 0.2221 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022590 Css NA 1.003 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022590 Css NA 0.145 mg/L PBTK NA 50% Rat Human -DTXSID7022590 Css NA 0.5748 mg/L PBTK NA 95% Rat Human -DTXSID7022592 Clint NA 35.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7022590 TK.Half.Life NA 1.401 hours 1compartment NA NA Rat Human +DTXSID7022590 Css NA 0.0285 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022590 Css NA 0.2093 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022590 Css NA 0.01967 mg/L PBTK NA 50% Rat Human +DTXSID7022590 Css NA 0.1263 mg/L PBTK NA 95% Rat Human +DTXSID7022592 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7022592 Fup 2e-04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7022592 Vd NA 33.84 L/kg 1compartment NA NA Human Human -DTXSID7022592 Days.Css NA 210 Days PBTK NA NA Human Human -DTXSID7022592 TK.Half.Life NA 857.3 hours 1compartment NA NA Human Human -DTXSID7022592 Css NA 1.576 mg/L 3compartmentss NA 50% Human Human -DTXSID7022592 Css NA 8.103 mg/L 3compartmentss NA 95% Human Human -DTXSID7022592 Css NA 1.048 mg/L PBTK NA 50% Human Human -DTXSID7022592 Css NA 5.436 mg/L PBTK NA 95% Human Human -DTXSID7022592 Clint NA 35.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7022592 Days.Css NA 359 Days PBTK NA NA Human Human +DTXSID7022592 TK.Half.Life NA 1396 hours 1compartment NA NA Human Human +DTXSID7022592 Css NA 4.292 mg/L 3compartmentss NA 50% Human Human +DTXSID7022592 Css NA 24.76 mg/L 3compartmentss NA 95% Human Human +DTXSID7022592 Css NA 3.133 mg/L PBTK NA 50% Human Human +DTXSID7022592 Css NA 18.07 mg/L PBTK NA 95% Human Human +DTXSID7022592 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7022592 Fup 2e-04 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7022592 Vd NA 36.72 L/kg 1compartment NA NA Rat Human -DTXSID7022592 Days.Css NA 114 Days PBTK NA NA Rat Human -DTXSID7022592 TK.Half.Life NA 118 hours 1compartment NA NA Rat Human -DTXSID7022592 Css NA 1.472 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022592 Css NA 6.455 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022592 Css NA 0.7958 mg/L PBTK NA 50% Rat Human -DTXSID7022592 Css NA 3.49 mg/L PBTK NA 95% Rat Human +DTXSID7022592 Days.Css NA 194 Days PBTK NA NA Rat Human +DTXSID7022592 TK.Half.Life NA 189 hours 1compartment NA NA Rat Human +DTXSID7022592 Css NA 0.4044 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022592 Css NA 2.058 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022592 Css NA 0.3056 mg/L PBTK NA 50% Rat Human +DTXSID7022592 Css NA 1.554 mg/L PBTK NA 95% Rat Human DTXSID7022594 Clint 12.46 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7022594 Fup 0.05 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID7022594 Vd NA 2.528 L/kg 1compartment NA NA Human Human DTXSID7022594 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7022594 TK.Half.Life NA 4.44 hours 1compartment NA NA Human Human -DTXSID7022594 Css NA 0.1586 mg/L 3compartmentss NA 50% Human Human -DTXSID7022594 Css NA 1.493 mg/L 3compartmentss NA 95% Human Human -DTXSID7022594 Css NA 0.1238 mg/L PBTK NA 50% Human Human -DTXSID7022594 Css NA 1.019 mg/L PBTK NA 95% Human Human +DTXSID7022594 Css NA 0.1381 mg/L 3compartmentss NA 50% Human Human +DTXSID7022594 Css NA 1.201 mg/L 3compartmentss NA 95% Human Human +DTXSID7022594 Css NA 0.1187 mg/L PBTK NA 50% Human Human +DTXSID7022594 Css NA 1.032 mg/L PBTK NA 95% Human Human DTXSID7022594 Clint 12.46 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID7022594 Fup 0.05 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human DTXSID7022594 Vd NA 2.423 L/kg 1compartment NA NA Rat Human DTXSID7022594 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7022594 TK.Half.Life NA 2.396 hours 1compartment NA NA Rat Human -DTXSID7022594 Css NA 0.088 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022594 Css NA 0.7295 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022594 Css NA 0.06616 mg/L PBTK NA 50% Rat Human -DTXSID7022594 Css NA 0.4677 mg/L PBTK NA 95% Rat Human -DTXSID7022598 Clint NA 14.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022598 Fup NA 0.1272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022598 Vd NA 1.616 L/kg 1compartment NA NA Human Human +DTXSID7022594 Css NA 0.0172 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022594 Css NA 0.1168 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022594 Css NA 0.01533 mg/L PBTK NA 50% Rat Human +DTXSID7022594 Css NA 0.104 mg/L PBTK NA 95% Rat Human +DTXSID7022596 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022596 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7022596 Vd NA 1.974 L/kg 1compartment NA NA Human Human +DTXSID7022596 Days.Css NA 41 Days PBTK NA NA Human Human +DTXSID7022596 TK.Half.Life NA 184.2 hours 1compartment NA NA Human Human +DTXSID7022596 Css NA 8.548 mg/L 3compartmentss NA 50% Human Human +DTXSID7022596 Css NA 73.33 mg/L 3compartmentss NA 95% Human Human +DTXSID7022596 Css NA 10.26 mg/L PBTK NA 50% Human Human +DTXSID7022596 Css NA 88 mg/L PBTK NA 95% Human Human +DTXSID7022596 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022596 Fup 0.005 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7022596 Vd NA 1.97 L/kg 1compartment NA NA Rat Human +DTXSID7022596 Days.Css NA 26 Days PBTK NA NA Rat Human +DTXSID7022596 TK.Half.Life NA 118.3 hours 1compartment NA NA Rat Human +DTXSID7022596 Css NA 0.9928 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022596 Css NA 6.764 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022596 Css NA 1.234 mg/L PBTK NA 50% Rat Human +DTXSID7022596 Css NA 8.407 mg/L PBTK NA 95% Rat Human +DTXSID7022598 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022598 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022598 Vd NA 2.239 L/kg 1compartment NA NA Human Human DTXSID7022598 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022598 TK.Half.Life NA 3.1 hours 1compartment NA NA Human Human -DTXSID7022598 Css NA 0.1637 mg/L 3compartmentss NA 50% Human Human -DTXSID7022598 Css NA 1.424 mg/L 3compartmentss NA 95% Human Human -DTXSID7022598 Css NA 0.1368 mg/L PBTK NA 50% Human Human -DTXSID7022598 Css NA 1.014 mg/L PBTK NA 95% Human Human -DTXSID7022598 Clint NA 14.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022598 Fup NA 0.1272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022598 Vd NA 1.575 L/kg 1compartment NA NA Rat Human +DTXSID7022598 TK.Half.Life NA 4.844 hours 1compartment NA NA Human Human +DTXSID7022598 Css NA 0.1371 mg/L 3compartmentss NA 50% Human Human +DTXSID7022598 Css NA 1.013 mg/L 3compartmentss NA 95% Human Human +DTXSID7022598 Css NA 0.1442 mg/L PBTK NA 50% Human Human +DTXSID7022598 Css NA 0.8784 mg/L PBTK NA 95% Human Human +DTXSID7022598 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022598 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022598 Vd NA 2.2 L/kg 1compartment NA NA Rat Human DTXSID7022598 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022598 TK.Half.Life NA 1.806 hours 1compartment NA NA Rat Human -DTXSID7022598 Css NA 0.0894 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022598 Css NA 0.6172 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022598 Css NA 0.07264 mg/L PBTK NA 50% Rat Human -DTXSID7022598 Css NA 0.4089 mg/L PBTK NA 95% Rat Human -DTXSID7022629 Clint NA 0.7337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7022598 TK.Half.Life NA 2.858 hours 1compartment NA NA Rat Human +DTXSID7022598 Css NA 0.0162 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022598 Css NA 0.0911 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022598 Css NA 0.01753 mg/L PBTK NA 50% Rat Human +DTXSID7022598 Css NA 0.0749 mg/L PBTK NA 95% Rat Human +DTXSID7022627 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022627 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7022627 Vd NA 4.76 L/kg 1compartment NA NA Human Human +DTXSID7022627 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7022627 TK.Half.Life NA 5.599 hours 1compartment NA NA Human Human +DTXSID7022627 Css NA 0.05784 mg/L 3compartmentss NA 50% Human Human +DTXSID7022627 Css NA 0.4903 mg/L 3compartmentss NA 95% Human Human +DTXSID7022627 Css NA 0.06708 mg/L PBTK NA 50% Human Human +DTXSID7022627 Css NA 0.475 mg/L PBTK NA 95% Human Human +DTXSID7022627 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022627 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7022627 Vd NA 4.401 L/kg 1compartment NA NA Rat Human +DTXSID7022627 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7022627 TK.Half.Life NA 2.047 hours 1compartment NA NA Rat Human +DTXSID7022627 Css NA 0.007202 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022627 Css NA 0.05017 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022627 Css NA 0.00871 mg/L PBTK NA 50% Rat Human +DTXSID7022627 Css NA 0.05087 mg/L PBTK NA 95% Rat Human +DTXSID7022629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7022629 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7022629 Vd NA 0.384 L/kg 1compartment NA NA Human Human -DTXSID7022629 Days.Css NA 232 Days PBTK NA NA Human Human -DTXSID7022629 TK.Half.Life NA 878.7 hours 1compartment NA NA Human Human -DTXSID7022629 Css NA 401.4 mg/L 3compartmentss NA 50% Human Human -DTXSID7022629 Css NA 2579 mg/L 3compartmentss NA 95% Human Human -DTXSID7022629 Css NA 233.2 mg/L PBTK NA 50% Human Human -DTXSID7022629 Css NA 1488 mg/L PBTK NA 95% Human Human -DTXSID7022629 Clint NA 0.7337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7022629 Vd NA 0.1654 L/kg 1compartment NA NA Human Human +DTXSID7022629 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID7022629 TK.Half.Life NA 28.27 hours 1compartment NA NA Human Human +DTXSID7022629 Css NA 31.9 mg/L 3compartmentss NA 50% Human Human +DTXSID7022629 Css NA 287.9 mg/L 3compartmentss NA 95% Human Human +DTXSID7022629 Css NA 18.48 mg/L PBTK NA 50% Human Human +DTXSID7022629 Css NA 166.3 mg/L PBTK NA 95% Human Human +DTXSID7022629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7022629 Fup 0.001 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7022629 Vd NA 0.2949 L/kg 1compartment NA NA Rat Human -DTXSID7022629 Days.Css NA 87 Days PBTK NA NA Rat Human -DTXSID7022629 TK.Half.Life NA 340.4 hours 1compartment NA NA Rat Human -DTXSID7022629 Css NA 171.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022629 Css NA 972.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022629 Css NA 93.5 mg/L PBTK NA 50% Rat Human -DTXSID7022629 Css NA 525.6 mg/L PBTK NA 95% Rat Human -DTXSID7022671 Clint NA 14.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022671 Fup NA 0.0498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022671 Vd NA 1.98 L/kg 1compartment NA NA Human Human -DTXSID7022671 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7022671 TK.Half.Life NA 15.18 hours 1compartment NA NA Human Human -DTXSID7022671 Css NA 1.086 mg/L 3compartmentss NA 50% Human Human -DTXSID7022671 Css NA 7.961 mg/L 3compartmentss NA 95% Human Human -DTXSID7022671 Css NA 0.7142 mg/L PBTK NA 50% Human Human -DTXSID7022671 Css NA 4.933 mg/L PBTK NA 95% Human Human -DTXSID7022671 Clint NA 14.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022671 Fup NA 0.0498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022671 Vd NA 1.48 L/kg 1compartment NA NA Rat Human +DTXSID7022629 Vd NA 0.1617 L/kg 1compartment NA NA Rat Human +DTXSID7022629 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7022629 TK.Half.Life NA 18.84 hours 1compartment NA NA Rat Human +DTXSID7022629 Css NA 4.254 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022629 Css NA 28.79 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022629 Css NA 2.382 mg/L PBTK NA 50% Rat Human +DTXSID7022629 Css NA 16.11 mg/L PBTK NA 95% Rat Human +DTXSID7022671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022671 Fup 0.0855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022671 Vd NA 1.158 L/kg 1compartment NA NA Human Human +DTXSID7022671 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7022671 TK.Half.Life NA 3.483 hours 1compartment NA NA Human Human +DTXSID7022671 Css NA 0.3449 mg/L 3compartmentss NA 50% Human Human +DTXSID7022671 Css NA 2.7 mg/L 3compartmentss NA 95% Human Human +DTXSID7022671 Css NA 0.2212 mg/L PBTK NA 50% Human Human +DTXSID7022671 Css NA 1.629 mg/L PBTK NA 95% Human Human +DTXSID7022671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022671 Fup 0.0855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022671 Vd NA 0.8847 L/kg 1compartment NA NA Rat Human DTXSID7022671 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022671 TK.Half.Life NA 4.909 hours 1compartment NA NA Rat Human -DTXSID7022671 Css NA 0.6045 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022671 Css NA 3.184 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022671 Css NA 0.373 mg/L PBTK NA 50% Rat Human -DTXSID7022671 Css NA 1.875 mg/L PBTK NA 95% Rat Human -DTXSID7022673 Clint NA 17.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022673 Fup NA 0.0509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022673 Vd NA 1.393 L/kg 1compartment NA NA Human Human +DTXSID7022671 TK.Half.Life NA 1.445 hours 1compartment NA NA Rat Human +DTXSID7022671 Css NA 0.04512 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022671 Css NA 0.2685 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022671 Css NA 0.02832 mg/L PBTK NA 50% Rat Human +DTXSID7022671 Css NA 0.1635 mg/L PBTK NA 95% Rat Human +DTXSID7022673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022673 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022673 Vd NA 1.898 L/kg 1compartment NA NA Human Human DTXSID7022673 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022673 TK.Half.Life NA 7.633 hours 1compartment NA NA Human Human -DTXSID7022673 Css NA 0.7862 mg/L 3compartmentss NA 50% Human Human -DTXSID7022673 Css NA 6.052 mg/L 3compartmentss NA 95% Human Human -DTXSID7022673 Css NA 0.5006 mg/L PBTK NA 50% Human Human -DTXSID7022673 Css NA 3.727 mg/L PBTK NA 95% Human Human -DTXSID7022673 Clint NA 17.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022673 Fup NA 0.0509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022673 Vd NA 1.044 L/kg 1compartment NA NA Rat Human +DTXSID7022673 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human +DTXSID7022673 Css NA 0.3272 mg/L 3compartmentss NA 50% Human Human +DTXSID7022673 Css NA 2.267 mg/L 3compartmentss NA 95% Human Human +DTXSID7022673 Css NA 0.2208 mg/L PBTK NA 50% Human Human +DTXSID7022673 Css NA 1.455 mg/L PBTK NA 95% Human Human +DTXSID7022673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022673 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022673 Vd NA 1.434 L/kg 1compartment NA NA Rat Human DTXSID7022673 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022673 TK.Half.Life NA 3.008 hours 1compartment NA NA Rat Human -DTXSID7022673 Css NA 0.4404 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022673 Css NA 2.559 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022673 Css NA 0.2628 mg/L PBTK NA 50% Rat Human -DTXSID7022673 Css NA 1.46 mg/L PBTK NA 95% Rat Human -DTXSID7022679 Clint NA 16.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022679 Fup NA 0.4284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022679 Vd NA 0.44 L/kg 1compartment NA NA Human Human +DTXSID7022673 TK.Half.Life NA 1.967 hours 1compartment NA NA Rat Human +DTXSID7022673 Css NA 0.04163 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022673 Css NA 0.2442 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022673 Css NA 0.02779 mg/L PBTK NA 50% Rat Human +DTXSID7022673 Css NA 0.1537 mg/L PBTK NA 95% Rat Human +DTXSID7022679 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022679 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022679 Vd NA 0.4502 L/kg 1compartment NA NA Human Human DTXSID7022679 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022679 TK.Half.Life NA 0.5398 hours 1compartment NA NA Human Human -DTXSID7022679 Css NA 0.06512 mg/L 3compartmentss NA 50% Human Human -DTXSID7022679 Css NA 0.5215 mg/L 3compartmentss NA 95% Human Human -DTXSID7022679 Css NA 0.04659 mg/L PBTK NA 50% Human Human -DTXSID7022679 Css NA 0.343 mg/L PBTK NA 95% Human Human -DTXSID7022679 Clint NA 16.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022679 Fup NA 0.4284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022679 Vd NA 0.4471 L/kg 1compartment NA NA Rat Human +DTXSID7022679 TK.Half.Life NA 4.794 hours 1compartment NA NA Human Human +DTXSID7022679 Css NA 0.7231 mg/L 3compartmentss NA 50% Human Human +DTXSID7022679 Css NA 4.805 mg/L 3compartmentss NA 95% Human Human +DTXSID7022679 Css NA 0.5286 mg/L PBTK NA 50% Human Human +DTXSID7022679 Css NA 2.984 mg/L PBTK NA 95% Human Human +DTXSID7022679 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022679 Fup 0.608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022679 Vd NA 0.4603 L/kg 1compartment NA NA Rat Human DTXSID7022679 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022679 TK.Half.Life NA 0.2862 hours 1compartment NA NA Rat Human -DTXSID7022679 Css NA 0.03458 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022679 Css NA 0.2077 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022679 Css NA 0.0238 mg/L PBTK NA 50% Rat Human -DTXSID7022679 Css NA 0.1289 mg/L PBTK NA 95% Rat Human -DTXSID7022704 Clint NA 185.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022704 Fup NA 0.246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022704 Vd NA 3.372 L/kg 1compartment NA NA Human Human +DTXSID7022679 TK.Half.Life NA 1.669 hours 1compartment NA NA Rat Human +DTXSID7022679 Css NA 0.003831 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022679 Css NA 0.02637 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022679 Css NA 0.002678 mg/L PBTK NA 50% Rat Human +DTXSID7022679 Css NA 0.01554 mg/L PBTK NA 95% Rat Human +DTXSID7022700 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID7022700 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7022700 Vd NA 0.5755 L/kg 1compartment NA NA Human Human +DTXSID7022700 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7022700 TK.Half.Life NA 5.986 hours 1compartment NA NA Human Human +DTXSID7022700 Css NA 1.65 mg/L 3compartmentss NA 50% Human Human +DTXSID7022700 Css NA 11.16 mg/L 3compartmentss NA 95% Human Human +DTXSID7022700 Css NA 1.024 mg/L PBTK NA 50% Human Human +DTXSID7022700 Css NA 6.688 mg/L PBTK NA 95% Human Human +DTXSID7022700 Clint 6 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID7022700 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7022700 Vd NA 0.5177 L/kg 1compartment NA NA Rat Human +DTXSID7022700 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7022700 TK.Half.Life NA 3.307 hours 1compartment NA NA Rat Human +DTXSID7022700 Css NA 0.2 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022700 Css NA 1.078 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022700 Css NA 0.1206 mg/L PBTK NA 50% Rat Human +DTXSID7022700 Css NA 0.6195 mg/L PBTK NA 95% Rat Human +DTXSID7022704 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022704 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022704 Vd NA 3.636 L/kg 1compartment NA NA Human Human DTXSID7022704 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022704 TK.Half.Life NA 2.029 hours 1compartment NA NA Human Human -DTXSID7022704 Css NA 0.007394 mg/L 3compartmentss NA 50% Human Human -DTXSID7022704 Css NA 0.05923 mg/L 3compartmentss NA 95% Human Human -DTXSID7022704 Css NA 0.007686 mg/L PBTK NA 50% Human Human -DTXSID7022704 Css NA 0.05166 mg/L PBTK NA 95% Human Human -DTXSID7022704 Clint NA 185.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022704 Fup NA 0.246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022704 Vd NA 3.249 L/kg 1compartment NA NA Rat Human +DTXSID7022704 TK.Half.Life NA 4.053 hours 1compartment NA NA Human Human +DTXSID7022704 Css NA 0.04916 mg/L 3compartmentss NA 50% Human Human +DTXSID7022704 Css NA 0.4227 mg/L 3compartmentss NA 95% Human Human +DTXSID7022704 Css NA 0.0538 mg/L PBTK NA 50% Human Human +DTXSID7022704 Css NA 0.3829 mg/L PBTK NA 95% Human Human +DTXSID7022704 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022704 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022704 Vd NA 3.512 L/kg 1compartment NA NA Rat Human DTXSID7022704 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022704 TK.Half.Life NA 0.8898 hours 1compartment NA NA Rat Human -DTXSID7022704 Css NA 0.003959 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022704 Css NA 0.02691 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022704 Css NA 0.004063 mg/L PBTK NA 50% Rat Human -DTXSID7022704 Css NA 0.02357 mg/L PBTK NA 95% Rat Human -DTXSID7022752 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7022704 TK.Half.Life NA 1.968 hours 1compartment NA NA Rat Human +DTXSID7022704 Css NA 0.006074 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022704 Css NA 0.03813 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022704 Css NA 0.006858 mg/L PBTK NA 50% Rat Human +DTXSID7022704 Css NA 0.035 mg/L PBTK NA 95% Rat Human +DTXSID7022706 Clint 16.98 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022706 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022706 Vd NA 2.192 L/kg 1compartment NA NA Human Human +DTXSID7022706 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7022706 TK.Half.Life NA 4.539 hours 1compartment NA NA Human Human +DTXSID7022706 Css NA 0.1551 mg/L 3compartmentss NA 50% Human Human +DTXSID7022706 Css NA 1.015 mg/L 3compartmentss NA 95% Human Human +DTXSID7022706 Css NA 0.1188 mg/L PBTK NA 50% Human Human +DTXSID7022706 Css NA 0.7233 mg/L PBTK NA 95% Human Human +DTXSID7022706 Clint 16.98 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022706 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022706 Vd NA 1.776 L/kg 1compartment NA NA Rat Human +DTXSID7022706 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7022706 TK.Half.Life NA 1.652 hours 1compartment NA NA Rat Human +DTXSID7022706 Css NA 0.01922 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022706 Css NA 0.09591 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022706 Css NA 0.01476 mg/L PBTK NA 50% Rat Human +DTXSID7022706 Css NA 0.06903 mg/L PBTK NA 95% Rat Human +DTXSID7022750 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022750 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7022750 Vd NA 0.3647 L/kg 1compartment NA NA Human Human +DTXSID7022750 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7022750 TK.Half.Life NA 9.454 hours 1compartment NA NA Human Human +DTXSID7022750 Css NA 1.707 mg/L 3compartmentss NA 50% Human Human +DTXSID7022750 Css NA 6.803 mg/L 3compartmentss NA 95% Human Human +DTXSID7022750 Css NA 1.13 mg/L PBTK NA 50% Human Human +DTXSID7022750 Css NA 4.156 mg/L PBTK NA 95% Human Human +DTXSID7022750 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022750 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7022750 Vd NA 0.3626 L/kg 1compartment NA NA Rat Human +DTXSID7022750 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7022750 TK.Half.Life NA 3.199 hours 1compartment NA NA Rat Human +DTXSID7022750 Css NA 0.009316 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022750 Css NA 0.03767 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022750 Css NA 0.005806 mg/L PBTK NA 50% Rat Human +DTXSID7022750 Css NA 0.02192 mg/L PBTK NA 95% Rat Human +DTXSID7022752 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7022752 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7022752 Vd NA 0.7267 L/kg 1compartment NA NA Human Human +DTXSID7022752 Vd NA 0.606 L/kg 1compartment NA NA Human Human DTXSID7022752 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7022752 TK.Half.Life NA 11.77 hours 1compartment NA NA Human Human -DTXSID7022752 Css NA 1.78 mg/L 3compartmentss NA 50% Human Human -DTXSID7022752 Css NA 7.932 mg/L 3compartmentss NA 95% Human Human -DTXSID7022752 Css NA 1.336 mg/L PBTK NA 50% Human Human -DTXSID7022752 Css NA 5.111 mg/L PBTK NA 95% Human Human -DTXSID7022752 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7022752 TK.Half.Life NA 9.8 hours 1compartment NA NA Human Human +DTXSID7022752 Css NA 0.9698 mg/L 3compartmentss NA 50% Human Human +DTXSID7022752 Css NA 4.609 mg/L 3compartmentss NA 95% Human Human +DTXSID7022752 Css NA 0.7152 mg/L PBTK NA 50% Human Human +DTXSID7022752 Css NA 2.949 mg/L PBTK NA 95% Human Human +DTXSID7022752 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7022752 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7022752 Vd NA 0.7334 L/kg 1compartment NA NA Rat Human +DTXSID7022752 Vd NA 0.6219 L/kg 1compartment NA NA Rat Human DTXSID7022752 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022752 TK.Half.Life NA 4.044 hours 1compartment NA NA Rat Human -DTXSID7022752 Css NA 0.4845 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022752 Css NA 1.853 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022752 Css NA 0.348 mg/L PBTK NA 50% Rat Human -DTXSID7022752 Css NA 1.104 mg/L PBTK NA 95% Rat Human -DTXSID7022754 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7022752 TK.Half.Life NA 3.426 hours 1compartment NA NA Rat Human +DTXSID7022752 Css NA 0.005287 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022752 Css NA 0.02454 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022752 Css NA 0.00373 mg/L PBTK NA 50% Rat Human +DTXSID7022752 Css NA 0.01497 mg/L PBTK NA 95% Rat Human +DTXSID7022754 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7022754 Fup 0.31 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7022754 Vd NA 0.4518 L/kg 1compartment NA NA Human Human +DTXSID7022754 Vd NA 0.3001 L/kg 1compartment NA NA Human Human DTXSID7022754 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022754 TK.Half.Life NA 9.429 hours 1compartment NA NA Human Human -DTXSID7022754 Css NA 1.158 mg/L 3compartmentss NA 50% Human Human -DTXSID7022754 Css NA 4.467 mg/L 3compartmentss NA 95% Human Human -DTXSID7022754 Css NA 0.7363 mg/L PBTK NA 50% Human Human -DTXSID7022754 Css NA 2.655 mg/L PBTK NA 95% Human Human -DTXSID7022754 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7022754 TK.Half.Life NA 6.261 hours 1compartment NA NA Human Human +DTXSID7022754 Css NA 1.478 mg/L 3compartmentss NA 50% Human Human +DTXSID7022754 Css NA 5.607 mg/L 3compartmentss NA 95% Human Human +DTXSID7022754 Css NA 0.9162 mg/L PBTK NA 50% Human Human +DTXSID7022754 Css NA 3.477 mg/L PBTK NA 95% Human Human +DTXSID7022754 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7022754 Fup 0.31 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7022754 Vd NA 0.525 L/kg 1compartment NA NA Rat Human +DTXSID7022754 Vd NA 0.3409 L/kg 1compartment NA NA Rat Human DTXSID7022754 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022754 TK.Half.Life NA 2.969 hours 1compartment NA NA Rat Human -DTXSID7022754 Css NA 0.601 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022754 Css NA 1.973 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022754 Css NA 0.3601 mg/L PBTK NA 50% Rat Human -DTXSID7022754 Css NA 1.104 mg/L PBTK NA 95% Rat Human +DTXSID7022754 TK.Half.Life NA 1.928 hours 1compartment NA NA Rat Human +DTXSID7022754 Css NA 0.006081 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022754 Css NA 0.02474 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022754 Css NA 0.00378 mg/L PBTK NA 50% Rat Human +DTXSID7022754 Css NA 0.01538 mg/L PBTK NA 95% Rat Human +DTXSID7022756 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022756 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7022756 Vd NA 0.2324 L/kg 1compartment NA NA Human Human +DTXSID7022756 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7022756 TK.Half.Life NA 10.02 hours 1compartment NA NA Human Human +DTXSID7022756 Css NA 3.375 mg/L 3compartmentss NA 50% Human Human +DTXSID7022756 Css NA 16.1 mg/L 3compartmentss NA 95% Human Human +DTXSID7022756 Css NA 2.08 mg/L PBTK NA 50% Human Human +DTXSID7022756 Css NA 9.491 mg/L PBTK NA 95% Human Human +DTXSID7022756 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022756 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7022756 Vd NA 0.2371 L/kg 1compartment NA NA Rat Human +DTXSID7022756 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7022756 TK.Half.Life NA 3.485 hours 1compartment NA NA Rat Human +DTXSID7022756 Css NA 0.01895 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022756 Css NA 0.08534 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022756 Css NA 0.01091 mg/L PBTK NA 50% Rat Human +DTXSID7022756 Css NA 0.04742 mg/L PBTK NA 95% Rat Human +DTXSID7022758 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022758 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7022758 Vd NA 0.1693 L/kg 1compartment NA NA Human Human +DTXSID7022758 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID7022758 TK.Half.Life NA 54.75 hours 1compartment NA NA Human Human +DTXSID7022758 Css NA 29.73 mg/L 3compartmentss NA 50% Human Human +DTXSID7022758 Css NA 195.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7022758 Css NA 17.3 mg/L PBTK NA 50% Human Human +DTXSID7022758 Css NA 113 mg/L PBTK NA 95% Human Human +DTXSID7022758 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022758 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7022758 Vd NA 0.1687 L/kg 1compartment NA NA Rat Human +DTXSID7022758 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7022758 TK.Half.Life NA 18.6 hours 1compartment NA NA Rat Human +DTXSID7022758 Css NA 0.1669 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022758 Css NA 1.043 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022758 Css NA 0.0909 mg/L PBTK NA 50% Rat Human +DTXSID7022758 Css NA 0.5669 mg/L PBTK NA 95% Rat Human DTXSID70227808 Clint 1.9 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID70227808 Fup 0.6 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID70227808 Vd NA 1.489 L/kg 1compartment NA NA Human Human DTXSID70227808 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID70227808 TK.Half.Life NA 5.026 hours 1compartment NA NA Human Human -DTXSID70227808 Css NA 0.3188 mg/L 3compartmentss NA 50% Human Human -DTXSID70227808 Css NA 2.356 mg/L 3compartmentss NA 95% Human Human -DTXSID70227808 Css NA 0.2754 mg/L PBTK NA 50% Human Human -DTXSID70227808 Css NA 1.574 mg/L PBTK NA 95% Human Human +DTXSID70227808 Css NA 0.3101 mg/L 3compartmentss NA 50% Human Human +DTXSID70227808 Css NA 2.318 mg/L 3compartmentss NA 95% Human Human +DTXSID70227808 Css NA 0.267 mg/L PBTK NA 50% Human Human +DTXSID70227808 Css NA 1.56 mg/L PBTK NA 95% Human Human DTXSID70227808 Clint 1.9 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID70227808 Fup 0.6 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID70227808 Vd NA 1.274 L/kg 1compartment NA NA Rat Human DTXSID70227808 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID70227808 TK.Half.Life NA 2.017 hours 1compartment NA NA Rat Human -DTXSID70227808 Css NA 0.1377 mg/L 3compartmentss NA 50% Rat Human -DTXSID70227808 Css NA 0.9241 mg/L 3compartmentss NA 95% Rat Human -DTXSID70227808 Css NA 0.1161 mg/L PBTK NA 50% Rat Human -DTXSID70227808 Css NA 0.5623 mg/L PBTK NA 95% Rat Human -DTXSID7022833 Clint NA 55.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022833 Fup NA 0.2709 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022833 Vd NA 1.641 L/kg 1compartment NA NA Human Human +DTXSID70227808 Css NA 0.03117 mg/L 3compartmentss NA 50% Rat Human +DTXSID70227808 Css NA 0.2 mg/L 3compartmentss NA 95% Rat Human +DTXSID70227808 Css NA 0.02698 mg/L PBTK NA 50% Rat Human +DTXSID70227808 Css NA 0.1258 mg/L PBTK NA 95% Rat Human +DTXSID7022833 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022833 Fup 0.415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022833 Vd NA 2.858 L/kg 1compartment NA NA Human Human DTXSID7022833 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022833 TK.Half.Life NA 1.444 hours 1compartment NA NA Human Human -DTXSID7022833 Css NA 0.02616 mg/L 3compartmentss NA 50% Human Human -DTXSID7022833 Css NA 0.2124 mg/L 3compartmentss NA 95% Human Human -DTXSID7022833 Css NA 0.0222 mg/L PBTK NA 50% Human Human -DTXSID7022833 Css NA 0.1601 mg/L PBTK NA 95% Human Human -DTXSID7022833 Clint NA 55.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022833 Fup NA 0.2709 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022833 Vd NA 1.647 L/kg 1compartment NA NA Rat Human +DTXSID7022833 TK.Half.Life NA 4.944 hours 1compartment NA NA Human Human +DTXSID7022833 Css NA 0.1038 mg/L 3compartmentss NA 50% Human Human +DTXSID7022833 Css NA 0.8236 mg/L 3compartmentss NA 95% Human Human +DTXSID7022833 Css NA 0.1126 mg/L PBTK NA 50% Human Human +DTXSID7022833 Css NA 0.706 mg/L PBTK NA 95% Human Human +DTXSID7022833 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022833 Fup 0.415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022833 Vd NA 2.898 L/kg 1compartment NA NA Rat Human DTXSID7022833 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022833 TK.Half.Life NA 0.7281 hours 1compartment NA NA Rat Human -DTXSID7022833 Css NA 0.01418 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022833 Css NA 0.08942 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022833 Css NA 0.01168 mg/L PBTK NA 50% Rat Human -DTXSID7022833 Css NA 0.06538 mg/L PBTK NA 95% Rat Human -DTXSID7022835 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022835 Fup NA 0.9841 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022835 Vd NA 2.7 L/kg 1compartment NA NA Human Human -DTXSID7022835 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID7022835 TK.Half.Life NA 52 hours 1compartment NA NA Human Human -DTXSID7022835 Css NA 1.882 mg/L 3compartmentss NA 50% Human Human -DTXSID7022835 Css NA 8.129 mg/L 3compartmentss NA 95% Human Human -DTXSID7022835 Css NA 1.653 mg/L PBTK NA 50% Human Human -DTXSID7022835 Css NA 5.679 mg/L PBTK NA 95% Human Human -DTXSID7022835 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022835 Fup NA 0.9841 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022835 Vd NA 2.134 L/kg 1compartment NA NA Rat Human -DTXSID7022835 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7022835 TK.Half.Life NA 6.98 hours 1compartment NA NA Rat Human -DTXSID7022835 Css NA 0.4976 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022835 Css NA 1.903 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022835 Css NA 0.4267 mg/L PBTK NA 50% Rat Human -DTXSID7022835 Css NA 1.236 mg/L PBTK NA 95% Rat Human +DTXSID7022833 TK.Half.Life NA 2.888 hours 1compartment NA NA Rat Human +DTXSID7022833 Css NA 0.01162 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022833 Css NA 0.0724 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022833 Css NA 0.01309 mg/L PBTK NA 50% Rat Human +DTXSID7022833 Css NA 0.05734 mg/L PBTK NA 95% Rat Human +DTXSID70228330 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70228330 Fup 0.614 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70228330 Vd NA 0.6719 L/kg 1compartment NA NA Human Human +DTXSID70228330 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70228330 TK.Half.Life NA 7.1 hours 1compartment NA NA Human Human +DTXSID70228330 Css NA 1.174 mg/L 3compartmentss NA 50% Human Human +DTXSID70228330 Css NA 8.076 mg/L 3compartmentss NA 95% Human Human +DTXSID70228330 Css NA 0.9341 mg/L PBTK NA 50% Human Human +DTXSID70228330 Css NA 5.105 mg/L PBTK NA 95% Human Human +DTXSID70228330 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70228330 Fup 0.614 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70228330 Vd NA 0.6853 L/kg 1compartment NA NA Rat Human +DTXSID70228330 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70228330 TK.Half.Life NA 2.462 hours 1compartment NA NA Rat Human +DTXSID70228330 Css NA 0.07224 mg/L 3compartmentss NA 50% Rat Human +DTXSID70228330 Css NA 0.4622 mg/L 3compartmentss NA 95% Rat Human +DTXSID70228330 Css NA 0.05708 mg/L PBTK NA 50% Rat Human +DTXSID70228330 Css NA 0.2802 mg/L PBTK NA 95% Rat Human +DTXSID7022835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022835 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022835 Vd NA 0.4461 L/kg 1compartment NA NA Human Human +DTXSID7022835 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7022835 TK.Half.Life NA 0.7627 hours 1compartment NA NA Human Human +DTXSID7022835 Css NA 0.1139 mg/L 3compartmentss NA 50% Human Human +DTXSID7022835 Css NA 0.8096 mg/L 3compartmentss NA 95% Human Human +DTXSID7022835 Css NA 0.07538 mg/L PBTK NA 50% Human Human +DTXSID7022835 Css NA 0.5046 mg/L PBTK NA 95% Human Human +DTXSID7022835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022835 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022835 Vd NA 0.4163 L/kg 1compartment NA NA Rat Human +DTXSID7022835 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7022835 TK.Half.Life NA 0.3936 hours 1compartment NA NA Rat Human +DTXSID7022835 Css NA 0.01463 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022835 Css NA 0.07548 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022835 Css NA 0.009414 mg/L PBTK NA 50% Rat Human +DTXSID7022835 Css NA 0.04665 mg/L PBTK NA 95% Rat Human DTXSID7022837 Clint 4.458 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID7022837 Fup NA 0.0213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022837 Vd NA 0.4788 L/kg 1compartment NA NA Human Human -DTXSID7022837 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7022837 TK.Half.Life NA 16.66 hours 1compartment NA NA Human Human -DTXSID7022837 Css NA 6.294 mg/L 3compartmentss NA 50% Human Human -DTXSID7022837 Css NA 50.29 mg/L 3compartmentss NA 95% Human Human -DTXSID7022837 Css NA 3.742 mg/L PBTK NA 50% Human Human -DTXSID7022837 Css NA 29.55 mg/L PBTK NA 95% Human Human +DTXSID7022837 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022837 Vd NA 1.786 L/kg 1compartment NA NA Human Human +DTXSID7022837 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7022837 TK.Half.Life NA 14.52 hours 1compartment NA NA Human Human +DTXSID7022837 Css NA 1.029 mg/L 3compartmentss NA 50% Human Human +DTXSID7022837 Css NA 6.227 mg/L 3compartmentss NA 95% Human Human +DTXSID7022837 Css NA 0.7059 mg/L PBTK NA 50% Human Human +DTXSID7022837 Css NA 3.97 mg/L PBTK NA 95% Human Human DTXSID7022837 Clint 4.458 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID7022837 Fup NA 0.0213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022837 Vd NA 0.3785 L/kg 1compartment NA NA Rat Human +DTXSID7022837 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022837 Vd NA 1.365 L/kg 1compartment NA NA Rat Human DTXSID7022837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022837 TK.Half.Life NA 8.016 hours 1compartment NA NA Rat Human -DTXSID7022837 Css NA 3.29 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022837 Css NA 20.11 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022837 Css NA 1.831 mg/L PBTK NA 50% Rat Human -DTXSID7022837 Css NA 10.95 mg/L PBTK NA 95% Rat Human -DTXSID7022839 Clint NA 1.005 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022839 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022839 Vd NA 12.82 L/kg 1compartment NA NA Human Human -DTXSID7022839 Days.Css NA 67 Days PBTK NA NA Human Human -DTXSID7022839 TK.Half.Life NA 322.4 hours 1compartment NA NA Human Human -DTXSID7022839 Css NA 1.892 mg/L 3compartmentss NA 50% Human Human -DTXSID7022839 Css NA 20.79 mg/L 3compartmentss NA 95% Human Human -DTXSID7022839 Css NA 2.6 mg/L PBTK NA 50% Human Human -DTXSID7022839 Css NA 20.23 mg/L PBTK NA 95% Human Human -DTXSID7022839 Clint NA 1.005 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022839 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022839 Vd NA 10.32 L/kg 1compartment NA NA Rat Human -DTXSID7022839 Days.Css NA 41 Days PBTK NA NA Rat Human -DTXSID7022839 TK.Half.Life NA 104.8 hours 1compartment NA NA Rat Human -DTXSID7022839 Css NA 0.9963 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022839 Css NA 8.919 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022839 Css NA 1.372 mg/L PBTK NA 50% Rat Human -DTXSID7022839 Css NA 8.645 mg/L PBTK NA 95% Rat Human -DTXSID7022883 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7022837 TK.Half.Life NA 4.951 hours 1compartment NA NA Rat Human +DTXSID7022837 Css NA 0.1208 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022837 Css NA 0.5179 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022837 Css NA 0.08188 mg/L PBTK NA 50% Rat Human +DTXSID7022837 Css NA 0.3179 mg/L PBTK NA 95% Rat Human +DTXSID7022839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022839 Fup 0.00527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022839 Vd NA 50.76 L/kg 1compartment NA NA Human Human +DTXSID7022839 Days.Css NA 385 Days PBTK NA NA Human Human +DTXSID7022839 TK.Half.Life NA 1523 hours 1compartment NA NA Human Human +DTXSID7022839 Css NA 0.4348 mg/L 3compartmentss NA 50% Human Human +DTXSID7022839 Css NA 2.799 mg/L 3compartmentss NA 95% Human Human +DTXSID7022839 Css NA 2.425 mg/L PBTK NA 50% Human Human +DTXSID7022839 Css NA 14.67 mg/L PBTK NA 95% Human Human +DTXSID7022839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022839 Fup 0.00527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022839 Vd NA 42.81 L/kg 1compartment NA NA Rat Human +DTXSID7022839 Days.Css NA 237 Days PBTK NA NA Rat Human +DTXSID7022839 TK.Half.Life NA 233.3 hours 1compartment NA NA Rat Human +DTXSID7022839 Css NA 0.05156 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022839 Css NA 0.2449 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022839 Css NA 0.3165 mg/L PBTK NA 50% Rat Human +DTXSID7022839 Css NA 1.605 mg/L PBTK NA 95% Rat Human +DTXSID70228476 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70228476 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70228476 Vd NA 1.741 L/kg 1compartment NA NA Human Human +DTXSID70228476 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70228476 TK.Half.Life NA 7.217 hours 1compartment NA NA Human Human +DTXSID70228476 Css NA 0.434 mg/L 3compartmentss NA 50% Human Human +DTXSID70228476 Css NA 3.47 mg/L 3compartmentss NA 95% Human Human +DTXSID70228476 Css NA 0.3612 mg/L PBTK NA 50% Human Human +DTXSID70228476 Css NA 2.426 mg/L PBTK NA 95% Human Human +DTXSID70228476 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70228476 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70228476 Vd NA 1.713 L/kg 1compartment NA NA Rat Human +DTXSID70228476 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70228476 TK.Half.Life NA 4.387 hours 1compartment NA NA Rat Human +DTXSID70228476 Css NA 0.05244 mg/L 3compartmentss NA 50% Rat Human +DTXSID70228476 Css NA 0.3348 mg/L 3compartmentss NA 95% Rat Human +DTXSID70228476 Css NA 0.0433 mg/L PBTK NA 50% Rat Human +DTXSID70228476 Css NA 0.2235 mg/L PBTK NA 95% Rat Human +DTXSID7022881 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022881 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022881 Vd NA 0.2711 L/kg 1compartment NA NA Human Human +DTXSID7022881 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7022881 TK.Half.Life NA 1.691 hours 1compartment NA NA Human Human +DTXSID7022881 Css NA 0.9072 mg/L 3compartmentss NA 50% Human Human +DTXSID7022881 Css NA 6.214 mg/L 3compartmentss NA 95% Human Human +DTXSID7022881 Css NA 0.5582 mg/L PBTK NA 50% Human Human +DTXSID7022881 Css NA 3.671 mg/L PBTK NA 95% Human Human +DTXSID7022881 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022881 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022881 Vd NA 0.2647 L/kg 1compartment NA NA Rat Human +DTXSID7022881 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7022881 TK.Half.Life NA 1.004 hours 1compartment NA NA Rat Human +DTXSID7022881 Css NA 0.1101 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022881 Css NA 0.5484 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022881 Css NA 0.06572 mg/L PBTK NA 50% Rat Human +DTXSID7022881 Css NA 0.3147 mg/L PBTK NA 95% Rat Human +DTXSID7022883 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7022883 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7022883 Vd NA 0.7809 L/kg 1compartment NA NA Human Human -DTXSID7022883 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7022883 TK.Half.Life NA 10.58 hours 1compartment NA NA Human Human -DTXSID7022883 Css NA 2.168 mg/L 3compartmentss NA 50% Human Human -DTXSID7022883 Css NA 14.17 mg/L 3compartmentss NA 95% Human Human -DTXSID7022883 Css NA 1.4 mg/L PBTK NA 50% Human Human -DTXSID7022883 Css NA 8.482 mg/L PBTK NA 95% Human Human -DTXSID7022883 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7022883 Vd NA 0.4594 L/kg 1compartment NA NA Human Human +DTXSID7022883 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID7022883 TK.Half.Life NA 50.67 hours 1compartment NA NA Human Human +DTXSID7022883 Css NA 9.692 mg/L 3compartmentss NA 50% Human Human +DTXSID7022883 Css NA 46.49 mg/L 3compartmentss NA 95% Human Human +DTXSID7022883 Css NA 5.908 mg/L PBTK NA 50% Human Human +DTXSID7022883 Css NA 26.96 mg/L PBTK NA 95% Human Human +DTXSID7022883 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7022883 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7022883 Vd NA 0.7571 L/kg 1compartment NA NA Rat Human -DTXSID7022883 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022883 TK.Half.Life NA 6.228 hours 1compartment NA NA Rat Human -DTXSID7022883 Css NA 1.113 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022883 Css NA 5.513 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022883 Css NA 0.6724 mg/L PBTK NA 50% Rat Human -DTXSID7022883 Css NA 3.1 mg/L PBTK NA 95% Rat Human +DTXSID7022883 Vd NA 0.3857 L/kg 1compartment NA NA Rat Human +DTXSID7022883 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7022883 TK.Half.Life NA 14.25 hours 1compartment NA NA Rat Human +DTXSID7022883 Css NA 0.05276 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022883 Css NA 0.2577 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022883 Css NA 0.03016 mg/L PBTK NA 50% Rat Human +DTXSID7022883 Css NA 0.1424 mg/L PBTK NA 95% Rat Human +DTXSID7022885 Clint 3.98 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022885 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022885 Vd NA 1.585 L/kg 1compartment NA NA Human Human +DTXSID7022885 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7022885 TK.Half.Life NA 4.965 hours 1compartment NA NA Human Human +DTXSID7022885 Css NA 0.2578 mg/L 3compartmentss NA 50% Human Human +DTXSID7022885 Css NA 1.704 mg/L 3compartmentss NA 95% Human Human +DTXSID7022885 Css NA 0.2205 mg/L PBTK NA 50% Human Human +DTXSID7022885 Css NA 1.231 mg/L PBTK NA 95% Human Human +DTXSID7022885 Clint 3.98 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022885 Fup 0.318 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022885 Vd NA 1.591 L/kg 1compartment NA NA Rat Human +DTXSID7022885 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7022885 TK.Half.Life NA 2.862 hours 1compartment NA NA Rat Human +DTXSID7022885 Css NA 0.0287 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022885 Css NA 0.1402 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022885 Css NA 0.02484 mg/L PBTK NA 50% Rat Human +DTXSID7022885 Css NA 0.09619 mg/L PBTK NA 95% Rat Human DTXSID7022910 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7022910 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7022910 Vd NA 0.5386 L/kg 1compartment NA NA Human Human DTXSID7022910 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7022910 TK.Half.Life NA 3.487 hours 1compartment NA NA Human Human -DTXSID7022910 Css NA 0.9116 mg/L 3compartmentss NA 50% Human Human -DTXSID7022910 Css NA 5.669 mg/L 3compartmentss NA 95% Human Human -DTXSID7022910 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID7022910 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID7022910 Css NA 0.7688 mg/L 3compartmentss NA 50% Human Human +DTXSID7022910 Css NA 5.209 mg/L 3compartmentss NA 95% Human Human +DTXSID7022910 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID7022910 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID7022910 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7022910 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7022910 Vd NA 0.5791 L/kg 1compartment NA NA Rat Human DTXSID7022910 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7022910 TK.Half.Life NA 1.277 hours 1compartment NA NA Rat Human -DTXSID7022910 Css NA 0.2312 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022910 Css NA 1.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022910 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID7022910 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID7022910 Css NA 0.0142 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022910 Css NA 0.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022910 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID7022910 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID7022912 Clint NA 4.088 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7022912 Fup NA 0.1249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022912 Vd NA 0.3218 L/kg 1compartment NA NA Human Human +DTXSID7022912 Vd NA 0.3681 L/kg 1compartment NA NA Human Human DTXSID7022912 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022912 TK.Half.Life NA 2.344 hours 1compartment NA NA Human Human -DTXSID7022912 Css NA 1.074 mg/L 3compartmentss NA 50% Human Human -DTXSID7022912 Css NA 6.878 mg/L 3compartmentss NA 95% Human Human -DTXSID7022912 Css NA 0.6772 mg/L PBTK NA 50% Human Human -DTXSID7022912 Css NA 4.125 mg/L PBTK NA 95% Human Human +DTXSID7022912 TK.Half.Life NA 2.694 hours 1compartment NA NA Human Human +DTXSID7022912 Css NA 0.5516 mg/L 3compartmentss NA 50% Human Human +DTXSID7022912 Css NA 3.854 mg/L 3compartmentss NA 95% Human Human +DTXSID7022912 Css NA 0.3566 mg/L PBTK NA 50% Human Human +DTXSID7022912 Css NA 2.352 mg/L PBTK NA 95% Human Human DTXSID7022912 Clint NA 4.088 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7022912 Fup NA 0.1249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022912 Vd NA 0.3211 L/kg 1compartment NA NA Rat Human +DTXSID7022912 Vd NA 0.3643 L/kg 1compartment NA NA Rat Human DTXSID7022912 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022912 TK.Half.Life NA 1.386 hours 1compartment NA NA Rat Human -DTXSID7022912 Css NA 0.5432 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022912 Css NA 2.566 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022912 Css NA 0.3217 mg/L PBTK NA 50% Rat Human -DTXSID7022912 Css NA 1.435 mg/L PBTK NA 95% Rat Human -DTXSID7022914 Clint NA 2.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7022912 TK.Half.Life NA 1.58 hours 1compartment NA NA Rat Human +DTXSID7022912 Css NA 0.005397 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022912 Css NA 0.03259 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022912 Css NA 0.003275 mg/L PBTK NA 50% Rat Human +DTXSID7022912 Css NA 0.01869 mg/L PBTK NA 95% Rat Human +DTXSID7022914 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7022914 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7022914 Vd NA 0.2387 L/kg 1compartment NA NA Human Human DTXSID7022914 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022914 TK.Half.Life NA 4.495 hours 1compartment NA NA Human Human -DTXSID7022914 Css NA 3.254 mg/L 3compartmentss NA 50% Human Human -DTXSID7022914 Css NA 19.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7022914 Css NA 1.955 mg/L PBTK NA 50% Human Human -DTXSID7022914 Css NA 11.04 mg/L PBTK NA 95% Human Human -DTXSID7022914 Clint NA 2.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7022914 TK.Half.Life NA 2.448 hours 1compartment NA NA Human Human +DTXSID7022914 Css NA 1.681 mg/L 3compartmentss NA 50% Human Human +DTXSID7022914 Css NA 11.21 mg/L 3compartmentss NA 95% Human Human +DTXSID7022914 Css NA 1.006 mg/L PBTK NA 50% Human Human +DTXSID7022914 Css NA 6.622 mg/L PBTK NA 95% Human Human +DTXSID7022914 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7022914 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7022914 Vd NA 0.2293 L/kg 1compartment NA NA Rat Human DTXSID7022914 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022914 TK.Half.Life NA 2.528 hours 1compartment NA NA Rat Human -DTXSID7022914 Css NA 1.596 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022914 Css NA 7.201 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022914 Css NA 0.8944 mg/L PBTK NA 50% Rat Human -DTXSID7022914 Css NA 3.925 mg/L PBTK NA 95% Rat Human -DTXSID7022918 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022918 Fup NA 0.6585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022918 Vd NA 0.6539 L/kg 1compartment NA NA Human Human +DTXSID7022914 TK.Half.Life NA 1.46 hours 1compartment NA NA Rat Human +DTXSID7022914 Css NA 0.2048 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022914 Css NA 1.084 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022914 Css NA 0.1186 mg/L PBTK NA 50% Rat Human +DTXSID7022914 Css NA 0.6119 mg/L PBTK NA 95% Rat Human +DTXSID7022918 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022918 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022918 Vd NA 0.5747 L/kg 1compartment NA NA Human Human DTXSID7022918 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022918 TK.Half.Life NA 6.442 hours 1compartment NA NA Human Human -DTXSID7022918 Css NA 1.159 mg/L 3compartmentss NA 50% Human Human -DTXSID7022918 Css NA 7.391 mg/L 3compartmentss NA 95% Human Human -DTXSID7022918 Css NA 0.9196 mg/L PBTK NA 50% Human Human -DTXSID7022918 Css NA 4.669 mg/L PBTK NA 95% Human Human -DTXSID7022918 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022918 Fup NA 0.6585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022918 Vd NA 0.6686 L/kg 1compartment NA NA Rat Human +DTXSID7022918 TK.Half.Life NA 7.081 hours 1compartment NA NA Human Human +DTXSID7022918 Css NA 1.384 mg/L 3compartmentss NA 50% Human Human +DTXSID7022918 Css NA 7.611 mg/L 3compartmentss NA 95% Human Human +DTXSID7022918 Css NA 1.046 mg/L PBTK NA 50% Human Human +DTXSID7022918 Css NA 4.75 mg/L PBTK NA 95% Human Human +DTXSID7022918 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022918 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022918 Vd NA 0.587 L/kg 1compartment NA NA Rat Human DTXSID7022918 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022918 TK.Half.Life NA 2.24 hours 1compartment NA NA Rat Human -DTXSID7022918 Css NA 0.3071 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022918 Css NA 1.854 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022918 Css NA 0.2331 mg/L PBTK NA 50% Rat Human -DTXSID7022918 Css NA 1.088 mg/L PBTK NA 95% Rat Human +DTXSID7022918 TK.Half.Life NA 2.461 hours 1compartment NA NA Rat Human +DTXSID7022918 Css NA 0.08555 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022918 Css NA 0.4382 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022918 Css NA 0.06416 mg/L PBTK NA 50% Rat Human +DTXSID7022918 Css NA 0.2655 mg/L PBTK NA 95% Rat Human +DTXSID7022960 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022960 Fup 0.541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022960 Vd NA 0.3693 L/kg 1compartment NA NA Human Human +DTXSID7022960 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7022960 TK.Half.Life NA 4.418 hours 1compartment NA NA Human Human +DTXSID7022960 Css NA 1.417 mg/L 3compartmentss NA 50% Human Human +DTXSID7022960 Css NA 8.019 mg/L 3compartmentss NA 95% Human Human +DTXSID7022960 Css NA 0.9974 mg/L PBTK NA 50% Human Human +DTXSID7022960 Css NA 4.982 mg/L PBTK NA 95% Human Human +DTXSID7022960 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022960 Fup 0.541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022960 Vd NA 0.3861 L/kg 1compartment NA NA Rat Human +DTXSID7022960 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7022960 TK.Half.Life NA 1.573 hours 1compartment NA NA Rat Human +DTXSID7022960 Css NA 0.07114 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022960 Css NA 0.3786 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022960 Css NA 0.04973 mg/L PBTK NA 50% Rat Human +DTXSID7022960 Css NA 0.2231 mg/L PBTK NA 95% Rat Human +DTXSID7022964 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID7022964 Fup 0.017 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7022964 Vd NA 1.152 L/kg 1compartment NA NA Human Human +DTXSID7022964 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID7022964 TK.Half.Life NA 53.69 hours 1compartment NA NA Human Human +DTXSID7022964 Css NA 7.966 mg/L 3compartmentss NA 50% Human Human +DTXSID7022964 Css NA 61.43 mg/L 3compartmentss NA 95% Human Human +DTXSID7022964 Css NA 4.893 mg/L PBTK NA 50% Human Human +DTXSID7022964 Css NA 36.23 mg/L PBTK NA 95% Human Human +DTXSID7022964 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID7022964 Fup 0.017 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7022964 Vd NA 0.8601 L/kg 1compartment NA NA Rat Human +DTXSID7022964 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7022964 TK.Half.Life NA 21.7 hours 1compartment NA NA Rat Human +DTXSID7022964 Css NA 0.953 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022964 Css NA 5.79 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022964 Css NA 0.5676 mg/L PBTK NA 50% Rat Human +DTXSID7022964 Css NA 3.314 mg/L PBTK NA 95% Rat Human DTXSID7022966 Clint 13 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID7022966 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7022966 Vd NA 4.344 L/kg 1compartment NA NA Human Human DTXSID7022966 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7022966 TK.Half.Life NA 4.049 hours 1compartment NA NA Human Human -DTXSID7022966 Css NA 0.03546 mg/L 3compartmentss NA 50% Human Human -DTXSID7022966 Css NA 0.303 mg/L 3compartmentss NA 95% Human Human -DTXSID7022966 Css NA 0.05062 mg/L PBTK NA 50% Human Human -DTXSID7022966 Css NA 0.3265 mg/L PBTK NA 95% Human Human +DTXSID7022966 Css NA 0.0342 mg/L 3compartmentss NA 50% Human Human +DTXSID7022966 Css NA 0.3082 mg/L 3compartmentss NA 95% Human Human +DTXSID7022966 Css NA 0.04799 mg/L PBTK NA 50% Human Human +DTXSID7022966 Css NA 0.3256 mg/L PBTK NA 95% Human Human DTXSID7022966 Clint 13 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID7022966 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7022966 Vd NA 4.326 L/kg 1compartment NA NA Rat Human DTXSID7022966 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7022966 TK.Half.Life NA 2.268 hours 1compartment NA NA Rat Human -DTXSID7022966 Css NA 0.01844 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022966 Css NA 0.1289 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022966 Css NA 0.02688 mg/L PBTK NA 50% Rat Human -DTXSID7022966 Css NA 0.1374 mg/L PBTK NA 95% Rat Human -DTXSID7022968 Clint NA 152.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022968 Fup NA 0.6183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7022968 Vd NA 0.4864 L/kg 1compartment NA NA Human Human +DTXSID7022966 Css NA 0.004013 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022966 Css NA 0.02924 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022966 Css NA 0.006116 mg/L PBTK NA 50% Rat Human +DTXSID7022966 Css NA 0.03272 mg/L PBTK NA 95% Rat Human +DTXSID7022968 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022968 Fup 0.72 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7022968 Vd NA 0.5372 L/kg 1compartment NA NA Human Human DTXSID7022968 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7022968 TK.Half.Life NA 0.3603 hours 1compartment NA NA Human Human -DTXSID7022968 Css NA 0.005606 mg/L 3compartmentss NA 50% Human Human -DTXSID7022968 Css NA 0.05914 mg/L 3compartmentss NA 95% Human Human -DTXSID7022968 Css NA 0.004082 mg/L PBTK NA 50% Human Human -DTXSID7022968 Css NA 0.03832 mg/L PBTK NA 95% Human Human -DTXSID7022968 Clint NA 152.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022968 Fup NA 0.6183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7022968 Vd NA 0.5059 L/kg 1compartment NA NA Rat Human +DTXSID7022968 TK.Half.Life NA 4.83 hours 1compartment NA NA Human Human +DTXSID7022968 Css NA 1.104 mg/L 3compartmentss NA 50% Human Human +DTXSID7022968 Css NA 6.839 mg/L 3compartmentss NA 95% Human Human +DTXSID7022968 Css NA 0.839 mg/L PBTK NA 50% Human Human +DTXSID7022968 Css NA 4.239 mg/L PBTK NA 95% Human Human +DTXSID7022968 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022968 Fup 0.72 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7022968 Vd NA 0.5577 L/kg 1compartment NA NA Rat Human DTXSID7022968 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7022968 TK.Half.Life NA 0.1657 hours 1compartment NA NA Rat Human -DTXSID7022968 Css NA 0.002956 mg/L 3compartmentss NA 50% Rat Human -DTXSID7022968 Css NA 0.02881 mg/L 3compartmentss NA 95% Rat Human -DTXSID7022968 Css NA 0.002085 mg/L PBTK NA 50% Rat Human -DTXSID7022968 Css NA 0.01767 mg/L PBTK NA 95% Rat Human -DTXSID7023011 Clint NA 0.9943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023011 Fup NA 0.0535 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023011 Vd NA 0.2618 L/kg 1compartment NA NA Human Human -DTXSID7023011 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7023011 TK.Half.Life NA 12.02 hours 1compartment NA NA Human Human -DTXSID7023011 Css NA 7.662 mg/L 3compartmentss NA 50% Human Human -DTXSID7023011 Css NA 42.24 mg/L 3compartmentss NA 95% Human Human -DTXSID7023011 Css NA 4.637 mg/L PBTK NA 50% Human Human -DTXSID7023011 Css NA 24.72 mg/L PBTK NA 95% Human Human -DTXSID7023011 Clint NA 0.9943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023011 Fup NA 0.0535 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023011 Vd NA 0.2593 L/kg 1compartment NA NA Rat Human +DTXSID7022968 TK.Half.Life NA 1.708 hours 1compartment NA NA Rat Human +DTXSID7022968 Css NA 0.06718 mg/L 3compartmentss NA 50% Rat Human +DTXSID7022968 Css NA 0.4025 mg/L 3compartmentss NA 95% Rat Human +DTXSID7022968 Css NA 0.05057 mg/L PBTK NA 50% Rat Human +DTXSID7022968 Css NA 0.2415 mg/L PBTK NA 95% Rat Human +DTXSID7023011 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023011 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023011 Vd NA 0.6077 L/kg 1compartment NA NA Human Human +DTXSID7023011 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023011 TK.Half.Life NA 1.532 hours 1compartment NA NA Human Human +DTXSID7023011 Css NA 0.2146 mg/L 3compartmentss NA 50% Human Human +DTXSID7023011 Css NA 1.392 mg/L 3compartmentss NA 95% Human Human +DTXSID7023011 Css NA 0.1609 mg/L PBTK NA 50% Human Human +DTXSID7023011 Css NA 0.9423 mg/L PBTK NA 95% Human Human +DTXSID7023011 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023011 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023011 Vd NA 0.608 L/kg 1compartment NA NA Rat Human DTXSID7023011 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023011 TK.Half.Life NA 5.945 hours 1compartment NA NA Rat Human -DTXSID7023011 Css NA 3.242 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023011 Css NA 14.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023011 Css NA 1.834 mg/L PBTK NA 50% Rat Human -DTXSID7023011 Css NA 7.654 mg/L PBTK NA 95% Rat Human -DTXSID7023019 Clint NA 0.4396 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023019 Fup NA 0.9703 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023019 Vd NA 1.032 L/kg 1compartment NA NA Human Human +DTXSID7023011 TK.Half.Life NA 0.882 hours 1compartment NA NA Rat Human +DTXSID7023011 Css NA 0.02518 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023011 Css NA 0.1205 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023011 Css NA 0.01873 mg/L PBTK NA 50% Rat Human +DTXSID7023011 Css NA 0.07834 mg/L PBTK NA 95% Rat Human +DTXSID7023019 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023019 Fup 0.895 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023019 Vd NA 0.9816 L/kg 1compartment NA NA Human Human DTXSID7023019 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023019 TK.Half.Life NA 4.143 hours 1compartment NA NA Human Human -DTXSID7023019 Css NA 0.4775 mg/L 3compartmentss NA 50% Human Human -DTXSID7023019 Css NA 2.862 mg/L 3compartmentss NA 95% Human Human -DTXSID7023019 Css NA 0.421 mg/L PBTK NA 50% Human Human -DTXSID7023019 Css NA 1.919 mg/L PBTK NA 95% Human Human -DTXSID7023019 Clint NA 0.4396 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023019 Fup NA 0.9703 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023019 Vd NA 1.024 L/kg 1compartment NA NA Rat Human +DTXSID7023019 TK.Half.Life NA 7.205 hours 1compartment NA NA Human Human +DTXSID7023019 Css NA 0.8205 mg/L 3compartmentss NA 50% Human Human +DTXSID7023019 Css NA 3.328 mg/L 3compartmentss NA 95% Human Human +DTXSID7023019 Css NA 0.7224 mg/L PBTK NA 50% Human Human +DTXSID7023019 Css NA 2.358 mg/L PBTK NA 95% Human Human +DTXSID7023019 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023019 Fup 0.895 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023019 Vd NA 0.9727 L/kg 1compartment NA NA Rat Human DTXSID7023019 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023019 TK.Half.Life NA 1.742 hours 1compartment NA NA Rat Human -DTXSID7023019 Css NA 0.1562 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023019 Css NA 0.9256 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023019 Css NA 0.1361 mg/L PBTK NA 50% Rat Human -DTXSID7023019 Css NA 0.5739 mg/L PBTK NA 95% Rat Human -DTXSID7023061 Clint NA 5.947 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023061 Fup NA 0.2255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023061 Vd NA 0.7857 L/kg 1compartment NA NA Human Human -DTXSID7023061 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023061 TK.Half.Life NA 2.639 hours 1compartment NA NA Human Human -DTXSID7023061 Css NA 0.3369 mg/L 3compartmentss NA 50% Human Human -DTXSID7023061 Css NA 1.968 mg/L 3compartmentss NA 95% Human Human -DTXSID7023061 Css NA 0.234 mg/L PBTK NA 50% Human Human -DTXSID7023061 Css NA 1.266 mg/L PBTK NA 95% Human Human -DTXSID7023061 Clint NA 5.947 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023061 Fup NA 0.2255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023061 Vd NA 0.674 L/kg 1compartment NA NA Rat Human +DTXSID7023019 TK.Half.Life NA 2.405 hours 1compartment NA NA Rat Human +DTXSID7023019 Css NA 0.04897 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023019 Css NA 0.1856 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023019 Css NA 0.04362 mg/L PBTK NA 50% Rat Human +DTXSID7023019 Css NA 0.1252 mg/L PBTK NA 95% Rat Human +DTXSID7023061 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023061 Fup 0.354 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023061 Vd NA 1.008 L/kg 1compartment NA NA Human Human +DTXSID7023061 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7023061 TK.Half.Life NA 20.07 hours 1compartment NA NA Human Human +DTXSID7023061 Css NA 2.099 mg/L 3compartmentss NA 50% Human Human +DTXSID7023061 Css NA 8.578 mg/L 3compartmentss NA 95% Human Human +DTXSID7023061 Css NA 1.59 mg/L PBTK NA 50% Human Human +DTXSID7023061 Css NA 5.553 mg/L PBTK NA 95% Human Human +DTXSID7023061 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023061 Fup 0.354 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023061 Vd NA 0.8678 L/kg 1compartment NA NA Rat Human DTXSID7023061 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023061 TK.Half.Life NA 1.281 hours 1compartment NA NA Rat Human -DTXSID7023061 Css NA 0.1723 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023061 Css NA 0.7483 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023061 Css NA 0.1148 mg/L PBTK NA 50% Rat Human -DTXSID7023061 Css NA 0.4485 mg/L PBTK NA 95% Rat Human -DTXSID7023063 Clint NA 0.2269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023063 Fup NA 0.0026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023063 Vd NA 0.2507 L/kg 1compartment NA NA Human Human -DTXSID7023063 Days.Css NA 113 Days PBTK NA NA Human Human -DTXSID7023063 TK.Half.Life NA 442.9 hours 1compartment NA NA Human Human -DTXSID7023063 Css NA 319 mg/L 3compartmentss NA 50% Human Human -DTXSID7023063 Css NA 1467 mg/L 3compartmentss NA 95% Human Human -DTXSID7023063 Css NA 186.3 mg/L PBTK NA 50% Human Human -DTXSID7023063 Css NA 855.2 mg/L PBTK NA 95% Human Human -DTXSID7023063 Clint NA 0.2269 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023063 Fup NA 0.0026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023063 Vd NA 0.226 L/kg 1compartment NA NA Rat Human -DTXSID7023063 Days.Css NA 37 Days PBTK NA NA Rat Human -DTXSID7023063 TK.Half.Life NA 159.7 hours 1compartment NA NA Rat Human -DTXSID7023063 Css NA 111.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023063 Css NA 425.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023063 Css NA 60.82 mg/L PBTK NA 50% Rat Human -DTXSID7023063 Css NA 230.4 mg/L PBTK NA 95% Rat Human +DTXSID7023061 TK.Half.Life NA 5.519 hours 1compartment NA NA Rat Human +DTXSID7023061 Css NA 0.1333 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023061 Css NA 0.468 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023061 Css NA 0.1001 mg/L PBTK NA 50% Rat Human +DTXSID7023061 Css NA 0.2918 mg/L PBTK NA 95% Rat Human +DTXSID7023063 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023063 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023063 Vd NA 0.6445 L/kg 1compartment NA NA Human Human +DTXSID7023063 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023063 TK.Half.Life NA 5.016 hours 1compartment NA NA Human Human +DTXSID7023063 Css NA 1.166 mg/L 3compartmentss NA 50% Human Human +DTXSID7023063 Css NA 11.76 mg/L 3compartmentss NA 95% Human Human +DTXSID7023063 Css NA 0.7634 mg/L PBTK NA 50% Human Human +DTXSID7023063 Css NA 7.175 mg/L PBTK NA 95% Human Human +DTXSID7023063 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023063 Fup 0.0236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023063 Vd NA 0.5675 L/kg 1compartment NA NA Rat Human +DTXSID7023063 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023063 TK.Half.Life NA 2.836 hours 1compartment NA NA Rat Human +DTXSID7023063 Css NA 0.1548 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023063 Css NA 1.265 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023063 Css NA 0.0977 mg/L PBTK NA 50% Rat Human +DTXSID7023063 Css NA 0.7376 mg/L PBTK NA 95% Rat Human DTXSID7023065 Clint 1.09 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7023065 Fup 0.25 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID7023065 Vd NA 1.749 L/kg 1compartment NA NA Human Human DTXSID7023065 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID7023065 TK.Half.Life NA 19.01 hours 1compartment NA NA Human Human -DTXSID7023065 Css NA 0.9412 mg/L 3compartmentss NA 50% Human Human -DTXSID7023065 Css NA 4.435 mg/L 3compartmentss NA 95% Human Human -DTXSID7023065 Css NA 0.8922 mg/L PBTK NA 50% Human Human -DTXSID7023065 Css NA 3.342 mg/L PBTK NA 95% Human Human +DTXSID7023065 Css NA 0.918 mg/L 3compartmentss NA 50% Human Human +DTXSID7023065 Css NA 4.316 mg/L 3compartmentss NA 95% Human Human +DTXSID7023065 Css NA 0.8642 mg/L PBTK NA 50% Human Human +DTXSID7023065 Css NA 3.293 mg/L PBTK NA 95% Human Human DTXSID7023065 Clint 1.09 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID7023065 Fup 0.25 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID7023065 Vd NA 1.55 L/kg 1compartment NA NA Rat Human DTXSID7023065 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7023065 TK.Half.Life NA 7.466 hours 1compartment NA NA Rat Human -DTXSID7023065 Css NA 0.381 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023065 Css NA 1.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023065 Css NA 0.3537 mg/L PBTK NA 50% Rat Human -DTXSID7023065 Css NA 1.024 mg/L PBTK NA 95% Rat Human +DTXSID7023065 Css NA 0.08592 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023065 Css NA 0.3244 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023065 Css NA 0.08246 mg/L PBTK NA 50% Rat Human +DTXSID7023065 Css NA 0.2335 mg/L PBTK NA 95% Rat Human DTXSID7023067 Clint 1 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID7023067 Fup 0.13 NA NA https://doi.org/10.1002/bdd.711 NA Human Human DTXSID7023067 Vd NA 4.38 L/kg 1compartment NA NA Human Human DTXSID7023067 Days.Css NA 6 Days PBTK NA NA Human Human DTXSID7023067 TK.Half.Life NA 48.88 hours 1compartment NA NA Human Human -DTXSID7023067 Css NA 1.316 mg/L 3compartmentss NA 50% Human Human -DTXSID7023067 Css NA 8.827 mg/L 3compartmentss NA 95% Human Human -DTXSID7023067 Css NA 1.058 mg/L PBTK NA 50% Human Human -DTXSID7023067 Css NA 5.904 mg/L PBTK NA 95% Human Human +DTXSID7023067 Css NA 1.242 mg/L 3compartmentss NA 50% Human Human +DTXSID7023067 Css NA 6.912 mg/L 3compartmentss NA 95% Human Human +DTXSID7023067 Css NA 1.029 mg/L PBTK NA 50% Human Human +DTXSID7023067 Css NA 5.734 mg/L PBTK NA 95% Human Human DTXSID7023067 Clint 1 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID7023067 Fup 0.13 NA NA https://doi.org/10.1002/bdd.711 NA Rat Human DTXSID7023067 Vd NA 4.34 L/kg 1compartment NA NA Rat Human DTXSID7023067 Days.Css NA 4 Days PBTK NA NA Rat Human DTXSID7023067 TK.Half.Life NA 27 hours 1compartment NA NA Rat Human -DTXSID7023067 Css NA 0.6054 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023067 Css NA 3.195 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023067 Css NA 0.4665 mg/L PBTK NA 50% Rat Human -DTXSID7023067 Css NA 1.95 mg/L PBTK NA 95% Rat Human -DTXSID7023140 Clint NA 28.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023140 Fup NA 0.023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023140 Vd NA 2.588 L/kg 1compartment NA NA Human Human +DTXSID7023067 Css NA 0.1275 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023067 Css NA 0.5362 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023067 Css NA 0.1096 mg/L PBTK NA 50% Rat Human +DTXSID7023067 Css NA 0.4608 mg/L PBTK NA 95% Rat Human +DTXSID7023140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023140 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023140 Vd NA 1.682 L/kg 1compartment NA NA Human Human DTXSID7023140 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7023140 TK.Half.Life NA 24.8 hours 1compartment NA NA Human Human -DTXSID7023140 Css NA 1.3 mg/L 3compartmentss NA 50% Human Human -DTXSID7023140 Css NA 9.313 mg/L 3compartmentss NA 95% Human Human -DTXSID7023140 Css NA 0.869 mg/L PBTK NA 50% Human Human -DTXSID7023140 Css NA 6.034 mg/L PBTK NA 95% Human Human -DTXSID7023140 Clint NA 28.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023140 Fup NA 0.023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023140 Vd NA 1.935 L/kg 1compartment NA NA Rat Human +DTXSID7023140 TK.Half.Life NA 24.05 hours 1compartment NA NA Human Human +DTXSID7023140 Css NA 2.265 mg/L 3compartmentss NA 50% Human Human +DTXSID7023140 Css NA 19.26 mg/L 3compartmentss NA 95% Human Human +DTXSID7023140 Css NA 1.42 mg/L PBTK NA 50% Human Human +DTXSID7023140 Css NA 11.69 mg/L PBTK NA 95% Human Human +DTXSID7023140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023140 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023140 Vd NA 1.244 L/kg 1compartment NA NA Rat Human DTXSID7023140 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7023140 TK.Half.Life NA 5.864 hours 1compartment NA NA Rat Human -DTXSID7023140 Css NA 0.7352 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023140 Css NA 4.258 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023140 Css NA 0.4654 mg/L PBTK NA 50% Rat Human -DTXSID7023140 Css NA 2.579 mg/L PBTK NA 95% Rat Human +DTXSID7023140 TK.Half.Life NA 8.74 hours 1compartment NA NA Rat Human +DTXSID7023140 Css NA 0.2962 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023140 Css NA 2.17 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023140 Css NA 0.1798 mg/L PBTK NA 50% Rat Human +DTXSID7023140 Css NA 1.281 mg/L PBTK NA 95% Rat Human +DTXSID7023142 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023142 Fup 0.076 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7023142 Vd NA 0.3885 L/kg 1compartment NA NA Human Human +DTXSID7023142 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023142 TK.Half.Life NA 3.209 hours 1compartment NA NA Human Human +DTXSID7023142 Css NA 0.6814 mg/L 3compartmentss NA 50% Human Human +DTXSID7023142 Css NA 4.942 mg/L 3compartmentss NA 95% Human Human +DTXSID7023142 Css NA 0.4194 mg/L PBTK NA 50% Human Human +DTXSID7023142 Css NA 2.929 mg/L PBTK NA 95% Human Human +DTXSID7023142 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023142 Fup 0.076 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7023142 Vd NA 0.3823 L/kg 1compartment NA NA Rat Human +DTXSID7023142 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023142 TK.Half.Life NA 1.947 hours 1compartment NA NA Rat Human +DTXSID7023142 Css NA 0.007008 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023142 Css NA 0.04329 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023142 Css NA 0.004065 mg/L PBTK NA 50% Rat Human +DTXSID7023142 Css NA 0.02409 mg/L PBTK NA 95% Rat Human DTXSID7023146 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7023146 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023146 Vd NA 0.6147 L/kg 1compartment NA NA Human Human +DTXSID7023146 Vd NA 0.6268 L/kg 1compartment NA NA Human Human DTXSID7023146 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023146 TK.Half.Life NA 3.979 hours 1compartment NA NA Human Human -DTXSID7023146 Css NA 0.8812 mg/L 3compartmentss NA 50% Human Human -DTXSID7023146 Css NA 5.615 mg/L 3compartmentss NA 95% Human Human -DTXSID7023146 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID7023146 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID7023146 TK.Half.Life NA 4.056 hours 1compartment NA NA Human Human +DTXSID7023146 Css NA 0.7407 mg/L 3compartmentss NA 50% Human Human +DTXSID7023146 Css NA 5.155 mg/L 3compartmentss NA 95% Human Human +DTXSID7023146 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID7023146 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID7023146 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7023146 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023146 Vd NA 0.6586 L/kg 1compartment NA NA Rat Human +DTXSID7023146 Vd NA 0.6686 L/kg 1compartment NA NA Rat Human DTXSID7023146 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023146 TK.Half.Life NA 1.452 hours 1compartment NA NA Rat Human -DTXSID7023146 Css NA 0.2225 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023146 Css NA 1.356 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023146 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID7023146 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID7023146 TK.Half.Life NA 1.474 hours 1compartment NA NA Rat Human +DTXSID7023146 Css NA 0.01365 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023146 Css NA 0.1021 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023146 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID7023146 Css NA 0.06515 mg/L PBTK NA 95% Rat Human DTXSID7023148 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7023148 Fup NA 0.0542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023148 Vd NA 0.2501 L/kg 1compartment NA NA Human Human -DTXSID7023148 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7023148 TK.Half.Life NA 29.85 hours 1compartment NA NA Human Human -DTXSID7023148 Css NA 20.05 mg/L 3compartmentss NA 50% Human Human -DTXSID7023148 Css NA 90.93 mg/L 3compartmentss NA 95% Human Human -DTXSID7023148 Css NA 12.11 mg/L PBTK NA 50% Human Human -DTXSID7023148 Css NA 53.39 mg/L PBTK NA 95% Human Human +DTXSID7023148 Vd NA 0.1933 L/kg 1compartment NA NA Human Human +DTXSID7023148 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7023148 TK.Half.Life NA 23.07 hours 1compartment NA NA Human Human +DTXSID7023148 Css NA 17.18 mg/L 3compartmentss NA 50% Human Human +DTXSID7023148 Css NA 78.79 mg/L 3compartmentss NA 95% Human Human +DTXSID7023148 Css NA 10.15 mg/L PBTK NA 50% Human Human +DTXSID7023148 Css NA 45.71 mg/L PBTK NA 95% Human Human DTXSID7023148 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7023148 Fup NA 0.0542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023148 Vd NA 0.2466 L/kg 1compartment NA NA Rat Human -DTXSID7023148 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7023148 TK.Half.Life NA 10.03 hours 1compartment NA NA Rat Human -DTXSID7023148 Css NA 5.553 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023148 Css NA 22.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023148 Css NA 3.133 mg/L PBTK NA 50% Rat Human -DTXSID7023148 Css NA 12.18 mg/L PBTK NA 95% Rat Human -DTXSID7023190 Clint NA 10 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023190 Fup NA 0.132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023190 Vd NA 3.077 L/kg 1compartment NA NA Human Human -DTXSID7023190 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023190 TK.Half.Life NA 8.738 hours 1compartment NA NA Human Human -DTXSID7023190 Css NA 0.2553 mg/L 3compartmentss NA 50% Human Human -DTXSID7023190 Css NA 2.075 mg/L 3compartmentss NA 95% Human Human -DTXSID7023190 Css NA 0.232 mg/L PBTK NA 50% Human Human -DTXSID7023190 Css NA 1.607 mg/L PBTK NA 95% Human Human -DTXSID7023190 Clint NA 10 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023190 Fup NA 0.132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023190 Vd NA 2.92 L/kg 1compartment NA NA Rat Human -DTXSID7023190 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023190 TK.Half.Life NA 4.432 hours 1compartment NA NA Rat Human -DTXSID7023190 Css NA 0.1372 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023190 Css NA 0.8739 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023190 Css NA 0.1218 mg/L PBTK NA 50% Rat Human -DTXSID7023190 Css NA 0.6145 mg/L PBTK NA 95% Rat Human +DTXSID7023148 Vd NA 0.1965 L/kg 1compartment NA NA Rat Human +DTXSID7023148 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023148 TK.Half.Life NA 7.993 hours 1compartment NA NA Rat Human +DTXSID7023148 Css NA 0.316 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023148 Css NA 2.128 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023148 Css NA 0.1775 mg/L PBTK NA 50% Rat Human +DTXSID7023148 Css NA 1.185 mg/L PBTK NA 95% Rat Human DTXSID7023192 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7023192 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7023192 Vd NA 0.4375 L/kg 1compartment NA NA Human Human DTXSID7023192 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7023192 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID7023192 Css NA 1.56 mg/L 3compartmentss NA 50% Human Human -DTXSID7023192 Css NA 7.454 mg/L 3compartmentss NA 95% Human Human -DTXSID7023192 Css NA 1.134 mg/L PBTK NA 50% Human Human -DTXSID7023192 Css NA 4.649 mg/L PBTK NA 95% Human Human +DTXSID7023192 Css NA 1.316 mg/L 3compartmentss NA 50% Human Human +DTXSID7023192 Css NA 6.429 mg/L 3compartmentss NA 95% Human Human +DTXSID7023192 Css NA 0.9592 mg/L PBTK NA 50% Human Human +DTXSID7023192 Css NA 4.025 mg/L PBTK NA 95% Human Human DTXSID7023192 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7023192 Fup NA 0.4837 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7023192 Vd NA 0.4563 L/kg 1compartment NA NA Rat Human DTXSID7023192 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7023192 TK.Half.Life NA 2.08 hours 1compartment NA NA Rat Human -DTXSID7023192 Css NA 0.4248 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023192 Css NA 1.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023192 Css NA 0.2941 mg/L PBTK NA 50% Rat Human -DTXSID7023192 Css NA 1.038 mg/L PBTK NA 95% Rat Human -DTXSID7023194 Clint NA 257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7023192 Css NA 0.02458 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023192 Css NA 0.1644 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023192 Css NA 0.01723 mg/L PBTK NA 50% Rat Human +DTXSID7023192 Css NA 0.1023 mg/L PBTK NA 95% Rat Human +DTXSID7023194 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7023194 Fup 0.94 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7023194 Vd NA 0.7282 L/kg 1compartment NA NA Human Human +DTXSID7023194 Vd NA 0.6023 L/kg 1compartment NA NA Human Human DTXSID7023194 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023194 TK.Half.Life NA 0.366 hours 1compartment NA NA Human Human -DTXSID7023194 Css NA 0.001863 mg/L 3compartmentss NA 50% Human Human -DTXSID7023194 Css NA 0.02195 mg/L 3compartmentss NA 95% Human Human -DTXSID7023194 Css NA 0.001722 mg/L PBTK NA 50% Human Human -DTXSID7023194 Css NA 0.01701 mg/L PBTK NA 95% Human Human -DTXSID7023194 Clint NA 257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7023194 TK.Half.Life NA 4.146 hours 1compartment NA NA Human Human +DTXSID7023194 Css NA 0.6156 mg/L 3compartmentss NA 50% Human Human +DTXSID7023194 Css NA 2.62 mg/L 3compartmentss NA 95% Human Human +DTXSID7023194 Css NA 0.6525 mg/L PBTK NA 50% Human Human +DTXSID7023194 Css NA 2.778 mg/L PBTK NA 95% Human Human +DTXSID7023194 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7023194 Fup 0.94 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7023194 Vd NA 0.7676 L/kg 1compartment NA NA Rat Human +DTXSID7023194 Vd NA 0.6304 L/kg 1compartment NA NA Rat Human DTXSID7023194 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023194 TK.Half.Life NA 0.1685 hours 1compartment NA NA Rat Human -DTXSID7023194 Css NA 0.001014 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023194 Css NA 0.01073 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023194 Css NA 0.000941 mg/L PBTK NA 50% Rat Human -DTXSID7023194 Css NA 0.008415 mg/L PBTK NA 95% Rat Human -DTXSID7023196 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023196 Fup NA 0.137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023196 Vd NA 0.5153 L/kg 1compartment NA NA Human Human -DTXSID7023196 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7023196 TK.Half.Life NA 24.76 hours 1compartment NA NA Human Human -DTXSID7023196 Css NA 7.006 mg/L 3compartmentss NA 50% Human Human -DTXSID7023196 Css NA 32.33 mg/L 3compartmentss NA 95% Human Human -DTXSID7023196 Css NA 4.534 mg/L PBTK NA 50% Human Human -DTXSID7023196 Css NA 19.19 mg/L PBTK NA 95% Human Human -DTXSID7023196 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023196 Fup NA 0.137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023196 Vd NA 0.4649 L/kg 1compartment NA NA Rat Human +DTXSID7023194 TK.Half.Life NA 1.479 hours 1compartment NA NA Rat Human +DTXSID7023194 Css NA 0.01515 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023194 Css NA 0.07636 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023194 Css NA 0.01628 mg/L PBTK NA 50% Rat Human +DTXSID7023194 Css NA 0.0831 mg/L PBTK NA 95% Rat Human +DTXSID7023196 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023196 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023196 Vd NA 1.032 L/kg 1compartment NA NA Human Human +DTXSID7023196 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7023196 TK.Half.Life NA 14.76 hours 1compartment NA NA Human Human +DTXSID7023196 Css NA 1.249 mg/L 3compartmentss NA 50% Human Human +DTXSID7023196 Css NA 6.362 mg/L 3compartmentss NA 95% Human Human +DTXSID7023196 Css NA 1.017 mg/L PBTK NA 50% Human Human +DTXSID7023196 Css NA 4.186 mg/L PBTK NA 95% Human Human +DTXSID7023196 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023196 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023196 Vd NA 0.9388 L/kg 1compartment NA NA Rat Human DTXSID7023196 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023196 TK.Half.Life NA 7.51 hours 1compartment NA NA Rat Human -DTXSID7023196 Css NA 1.939 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023196 Css NA 7.581 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023196 Css NA 1.173 mg/L PBTK NA 50% Rat Human -DTXSID7023196 Css NA 4.23 mg/L PBTK NA 95% Rat Human -DTXSID7023198 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023198 Fup NA 0.1967 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023198 Vd NA 0.388 L/kg 1compartment NA NA Human Human -DTXSID7023198 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7023198 TK.Half.Life NA 12.78 hours 1compartment NA NA Human Human -DTXSID7023198 Css NA 4.107 mg/L 3compartmentss NA 50% Human Human -DTXSID7023198 Css NA 15.04 mg/L 3compartmentss NA 95% Human Human -DTXSID7023198 Css NA 2.701 mg/L PBTK NA 50% Human Human -DTXSID7023198 Css NA 9.193 mg/L PBTK NA 95% Human Human -DTXSID7023198 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023198 Fup NA 0.1967 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023198 Vd NA 0.3875 L/kg 1compartment NA NA Rat Human +DTXSID7023196 TK.Half.Life NA 4.381 hours 1compartment NA NA Rat Human +DTXSID7023196 Css NA 0.02318 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023196 Css NA 0.1635 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023196 Css NA 0.01834 mg/L PBTK NA 50% Rat Human +DTXSID7023196 Css NA 0.1078 mg/L PBTK NA 95% Rat Human +DTXSID7023198 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023198 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023198 Vd NA 0.7141 L/kg 1compartment NA NA Human Human +DTXSID7023198 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023198 TK.Half.Life NA 7.936 hours 1compartment NA NA Human Human +DTXSID7023198 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human +DTXSID7023198 Css NA 7.59 mg/L 3compartmentss NA 95% Human Human +DTXSID7023198 Css NA 0.8604 mg/L PBTK NA 50% Human Human +DTXSID7023198 Css NA 4.743 mg/L PBTK NA 95% Human Human +DTXSID7023198 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023198 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023198 Vd NA 0.7188 L/kg 1compartment NA NA Rat Human DTXSID7023198 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023198 TK.Half.Life NA 4.346 hours 1compartment NA NA Rat Human -DTXSID7023198 Css NA 1.136 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023198 Css NA 3.378 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023198 Css NA 0.705 mg/L PBTK NA 50% Rat Human -DTXSID7023198 Css NA 1.924 mg/L PBTK NA 95% Rat Human -DTXSID7023221 Clint NA 30.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023221 Fup NA 0.1369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023221 Vd NA 2.857 L/kg 1compartment NA NA Human Human +DTXSID7023198 TK.Half.Life NA 2.712 hours 1compartment NA NA Rat Human +DTXSID7023198 Css NA 0.02035 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023198 Css NA 0.1779 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023198 Css NA 0.01575 mg/L PBTK NA 50% Rat Human +DTXSID7023198 Css NA 0.1115 mg/L PBTK NA 95% Rat Human +DTXSID7023221 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023221 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023221 Vd NA 3.615 L/kg 1compartment NA NA Human Human DTXSID7023221 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023221 TK.Half.Life NA 3.339 hours 1compartment NA NA Human Human -DTXSID7023221 Css NA 0.06906 mg/L 3compartmentss NA 50% Human Human -DTXSID7023221 Css NA 0.6574 mg/L 3compartmentss NA 95% Human Human -DTXSID7023221 Css NA 0.06629 mg/L PBTK NA 50% Human Human -DTXSID7023221 Css NA 0.505 mg/L PBTK NA 95% Human Human -DTXSID7023221 Clint NA 30.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023221 Fup NA 0.1369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023221 Vd NA 2.857 L/kg 1compartment NA NA Rat Human +DTXSID7023221 TK.Half.Life NA 9.23 hours 1compartment NA NA Human Human +DTXSID7023221 Css NA 0.1562 mg/L 3compartmentss NA 50% Human Human +DTXSID7023221 Css NA 1.192 mg/L 3compartmentss NA 95% Human Human +DTXSID7023221 Css NA 0.1818 mg/L PBTK NA 50% Human Human +DTXSID7023221 Css NA 1.082 mg/L PBTK NA 95% Human Human +DTXSID7023221 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023221 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023221 Vd NA 3.632 L/kg 1compartment NA NA Rat Human DTXSID7023221 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023221 TK.Half.Life NA 1.87 hours 1compartment NA NA Rat Human -DTXSID7023221 Css NA 0.03775 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023221 Css NA 0.2975 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023221 Css NA 0.03546 mg/L PBTK NA 50% Rat Human -DTXSID7023221 Css NA 0.2219 mg/L PBTK NA 95% Rat Human +DTXSID7023221 TK.Half.Life NA 5.484 hours 1compartment NA NA Rat Human +DTXSID7023221 Css NA 0.01827 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023221 Css NA 0.1052 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023221 Css NA 0.02207 mg/L PBTK NA 50% Rat Human +DTXSID7023221 Css NA 0.09557 mg/L PBTK NA 95% Rat Human DTXSID7023225 Clint 0.7399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7023225 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7023225 Vd NA 1.04 L/kg 1compartment NA NA Human Human DTXSID7023225 Days.Css NA 6 Days PBTK NA NA Human Human DTXSID7023225 TK.Half.Life NA 36.71 hours 1compartment NA NA Human Human -DTXSID7023225 Css NA 3.645 mg/L 3compartmentss NA 50% Human Human -DTXSID7023225 Css NA 21.33 mg/L 3compartmentss NA 95% Human Human -DTXSID7023225 Css NA 3.387 mg/L PBTK NA 50% Human Human -DTXSID7023225 Css NA 14.76 mg/L PBTK NA 95% Human Human +DTXSID7023225 Css NA 3.197 mg/L 3compartmentss NA 50% Human Human +DTXSID7023225 Css NA 14.3 mg/L 3compartmentss NA 95% Human Human +DTXSID7023225 Css NA 3.356 mg/L PBTK NA 50% Human Human +DTXSID7023225 Css NA 15.01 mg/L PBTK NA 95% Human Human DTXSID7023225 Clint 0.7399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID7023225 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7023225 Vd NA 0.8115 L/kg 1compartment NA NA Rat Human DTXSID7023225 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID7023225 TK.Half.Life NA 12.41 hours 1compartment NA NA Rat Human -DTXSID7023225 Css NA 1.432 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023225 Css NA 7.474 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023225 Css NA 1.287 mg/L PBTK NA 50% Rat Human -DTXSID7023225 Css NA 4.786 mg/L PBTK NA 95% Rat Human -DTXSID7023227 Clint NA 0.6154 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7023225 Css NA 0.2798 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023225 Css NA 1.015 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023225 Css NA 0.304 mg/L PBTK NA 50% Rat Human +DTXSID7023225 Css NA 1.104 mg/L PBTK NA 95% Rat Human +DTXSID7023227 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7023227 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7023227 Vd NA 0.7004 L/kg 1compartment NA NA Human Human -DTXSID7023227 Days.Css NA 49 Days PBTK NA NA Human Human -DTXSID7023227 TK.Half.Life NA 211.9 hours 1compartment NA NA Human Human -DTXSID7023227 Css NA 53.64 mg/L 3compartmentss NA 50% Human Human -DTXSID7023227 Css NA 329.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7023227 Css NA 30.87 mg/L PBTK NA 50% Human Human -DTXSID7023227 Css NA 189.7 mg/L PBTK NA 95% Human Human -DTXSID7023227 Clint NA 0.6154 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7023227 Vd NA 0.2582 L/kg 1compartment NA NA Human Human +DTXSID7023227 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023227 TK.Half.Life NA 4.519 hours 1compartment NA NA Human Human +DTXSID7023227 Css NA 3.32 mg/L 3compartmentss NA 50% Human Human +DTXSID7023227 Css NA 32.91 mg/L 3compartmentss NA 95% Human Human +DTXSID7023227 Css NA 1.826 mg/L PBTK NA 50% Human Human +DTXSID7023227 Css NA 18.1 mg/L PBTK NA 95% Human Human +DTXSID7023227 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7023227 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7023227 Vd NA 0.5212 L/kg 1compartment NA NA Rat Human -DTXSID7023227 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID7023227 TK.Half.Life NA 71.37 hours 1compartment NA NA Rat Human -DTXSID7023227 Css NA 22.03 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023227 Css NA 115.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023227 Css NA 11.73 mg/L PBTK NA 50% Rat Human -DTXSID7023227 Css NA 62.37 mg/L PBTK NA 95% Rat Human +DTXSID7023227 Vd NA 0.2217 L/kg 1compartment NA NA Rat Human +DTXSID7023227 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023227 TK.Half.Life NA 2.584 hours 1compartment NA NA Rat Human +DTXSID7023227 Css NA 0.4082 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023227 Css NA 3.366 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023227 Css NA 0.2325 mg/L PBTK NA 50% Rat Human +DTXSID7023227 Css NA 1.917 mg/L PBTK NA 95% Rat Human DTXSID7023273 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7023273 Fup 0.21 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7023273 Vd NA 3.082 L/kg 1compartment NA NA Human Human DTXSID7023273 Days.Css NA 281 Days PBTK NA NA Human Human DTXSID7023273 TK.Half.Life NA 1103 hours 1compartment NA NA Human Human -DTXSID7023273 Css NA 44.46 mg/L 3compartmentss NA 50% Human Human -DTXSID7023273 Css NA 117.5 mg/L 3compartmentss NA 95% Human Human -DTXSID7023273 Css NA 26.39 mg/L PBTK NA 50% Human Human -DTXSID7023273 Css NA 68.76 mg/L PBTK NA 95% Human Human +DTXSID7023273 Css NA 36.92 mg/L 3compartmentss NA 50% Human Human +DTXSID7023273 Css NA 94.96 mg/L 3compartmentss NA 95% Human Human +DTXSID7023273 Css NA 27.7 mg/L PBTK NA 50% Human Human +DTXSID7023273 Css NA 71.22 mg/L PBTK NA 95% Human Human DTXSID7023273 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID7023273 Fup 0.21 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7023273 Vd NA 2.351 L/kg 1compartment NA NA Rat Human DTXSID7023273 Days.Css NA 70 Days PBTK NA NA Rat Human DTXSID7023273 TK.Half.Life NA 87.14 hours 1compartment NA NA Rat Human -DTXSID7023273 Css NA 13.27 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023273 Css NA 26.72 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023273 Css NA 7.392 mg/L PBTK NA 50% Rat Human -DTXSID7023273 Css NA 14.66 mg/L PBTK NA 95% Rat Human -DTXSID7023277 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023277 Fup NA 0.9903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023277 Vd NA 3.694 L/kg 1compartment NA NA Human Human +DTXSID7023273 Css NA 2.228 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023273 Css NA 4.431 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023273 Css NA 1.73 mg/L PBTK NA 50% Rat Human +DTXSID7023273 Css NA 3.442 mg/L PBTK NA 95% Rat Human +DTXSID7023277 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023277 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023277 Vd NA 0.5785 L/kg 1compartment NA NA Human Human DTXSID7023277 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023277 TK.Half.Life NA 9.936 hours 1compartment NA NA Human Human -DTXSID7023277 Css NA 0.2154 mg/L 3compartmentss NA 50% Human Human -DTXSID7023277 Css NA 1.481 mg/L 3compartmentss NA 95% Human Human -DTXSID7023277 Css NA 0.1927 mg/L PBTK NA 50% Human Human -DTXSID7023277 Css NA 1.198 mg/L PBTK NA 95% Human Human -DTXSID7023277 Clint NA 10.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023277 Fup NA 0.9903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023277 Vd NA 3.065 L/kg 1compartment NA NA Rat Human +DTXSID7023277 TK.Half.Life NA 2.277 hours 1compartment NA NA Human Human +DTXSID7023277 Css NA 0.4018 mg/L 3compartmentss NA 50% Human Human +DTXSID7023277 Css NA 2.349 mg/L 3compartmentss NA 95% Human Human +DTXSID7023277 Css NA 0.2697 mg/L PBTK NA 50% Human Human +DTXSID7023277 Css NA 1.474 mg/L PBTK NA 95% Human Human +DTXSID7023277 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023277 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023277 Vd NA 0.5764 L/kg 1compartment NA NA Rat Human DTXSID7023277 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023277 TK.Half.Life NA 2.166 hours 1compartment NA NA Rat Human -DTXSID7023277 Css NA 0.1087 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023277 Css NA 0.584 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023277 Css NA 0.09652 mg/L PBTK NA 50% Rat Human -DTXSID7023277 Css NA 0.4544 mg/L PBTK NA 95% Rat Human -DTXSID7023279 Clint NA 7.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023279 Fup NA 0.0658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023279 Vd NA 1.141 L/kg 1compartment NA NA Human Human +DTXSID7023277 TK.Half.Life NA 1.346 hours 1compartment NA NA Rat Human +DTXSID7023277 Css NA 0.04847 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023277 Css NA 0.2084 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023277 Css NA 0.03191 mg/L PBTK NA 50% Rat Human +DTXSID7023277 Css NA 0.126 mg/L PBTK NA 95% Rat Human +DTXSID7023279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023279 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023279 Vd NA 1.58 L/kg 1compartment NA NA Human Human DTXSID7023279 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023279 TK.Half.Life NA 9.299 hours 1compartment NA NA Human Human -DTXSID7023279 Css NA 1.236 mg/L 3compartmentss NA 50% Human Human -DTXSID7023279 Css NA 7.871 mg/L 3compartmentss NA 95% Human Human -DTXSID7023279 Css NA 0.781 mg/L PBTK NA 50% Human Human -DTXSID7023279 Css NA 4.85 mg/L PBTK NA 95% Human Human -DTXSID7023279 Clint NA 7.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023279 Fup NA 0.0658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023279 Vd NA 0.8736 L/kg 1compartment NA NA Rat Human +DTXSID7023279 TK.Half.Life NA 3.511 hours 1compartment NA NA Human Human +DTXSID7023279 Css NA 0.1978 mg/L 3compartmentss NA 50% Human Human +DTXSID7023279 Css NA 1.49 mg/L 3compartmentss NA 95% Human Human +DTXSID7023279 Css NA 0.136 mg/L PBTK NA 50% Human Human +DTXSID7023279 Css NA 0.9566 mg/L PBTK NA 95% Human Human +DTXSID7023279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023279 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023279 Vd NA 1.224 L/kg 1compartment NA NA Rat Human DTXSID7023279 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023279 TK.Half.Life NA 3.945 hours 1compartment NA NA Rat Human -DTXSID7023279 Css NA 0.6559 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023279 Css NA 3.186 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023279 Css NA 0.3923 mg/L PBTK NA 50% Rat Human -DTXSID7023279 Css NA 1.82 mg/L PBTK NA 95% Rat Human +DTXSID7023279 TK.Half.Life NA 1.34 hours 1compartment NA NA Rat Human +DTXSID7023279 Css NA 0.0257 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023279 Css NA 0.1486 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023279 Css NA 0.01745 mg/L PBTK NA 50% Rat Human +DTXSID7023279 Css NA 0.09472 mg/L PBTK NA 95% Rat Human DTXSID7023300 Clint 5.452 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7023300 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7023300 Vd NA 0.9309 L/kg 1compartment NA NA Human Human +DTXSID7023300 Vd NA 0.7878 L/kg 1compartment NA NA Human Human DTXSID7023300 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023300 TK.Half.Life NA 3.244 hours 1compartment NA NA Human Human -DTXSID7023300 Css NA 0.3281 mg/L 3compartmentss NA 50% Human Human -DTXSID7023300 Css NA 1.882 mg/L 3compartmentss NA 95% Human Human -DTXSID7023300 Css NA 0.2524 mg/L PBTK NA 50% Human Human -DTXSID7023300 Css NA 1.31 mg/L PBTK NA 95% Human Human +DTXSID7023300 TK.Half.Life NA 2.699 hours 1compartment NA NA Human Human +DTXSID7023300 Css NA 0.3124 mg/L 3compartmentss NA 50% Human Human +DTXSID7023300 Css NA 1.656 mg/L 3compartmentss NA 95% Human Human +DTXSID7023300 Css NA 0.243 mg/L PBTK NA 50% Human Human +DTXSID7023300 Css NA 1.29 mg/L PBTK NA 95% Human Human DTXSID7023300 Clint 5.452 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID7023300 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7023300 Vd NA 0.7866 L/kg 1compartment NA NA Rat Human +DTXSID7023300 Vd NA 0.6851 L/kg 1compartment NA NA Rat Human DTXSID7023300 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023300 TK.Half.Life NA 1.536 hours 1compartment NA NA Rat Human -DTXSID7023300 Css NA 0.1665 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023300 Css NA 0.7113 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023300 Css NA 0.1238 mg/L PBTK NA 50% Rat Human -DTXSID7023300 Css NA 0.4573 mg/L PBTK NA 95% Rat Human -DTXSID7023302 Clint NA 20.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023302 Fup NA 0.1634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023302 Vd NA 1.533 L/kg 1compartment NA NA Human Human +DTXSID7023300 TK.Half.Life NA 1.34 hours 1compartment NA NA Rat Human +DTXSID7023300 Css NA 0.0346 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023300 Css NA 0.1328 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023300 Css NA 0.02795 mg/L PBTK NA 50% Rat Human +DTXSID7023300 Css NA 0.1072 mg/L PBTK NA 95% Rat Human +DTXSID7023302 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023302 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023302 Vd NA 1.689 L/kg 1compartment NA NA Human Human DTXSID7023302 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023302 TK.Half.Life NA 3.274 hours 1compartment NA NA Human Human -DTXSID7023302 Css NA 0.1832 mg/L 3compartmentss NA 50% Human Human -DTXSID7023302 Css NA 1.259 mg/L 3compartmentss NA 95% Human Human -DTXSID7023302 Css NA 0.1277 mg/L PBTK NA 50% Human Human -DTXSID7023302 Css NA 0.8289 mg/L PBTK NA 95% Human Human -DTXSID7023302 Clint NA 20.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023302 Fup NA 0.1634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023302 Vd NA 1.194 L/kg 1compartment NA NA Rat Human +DTXSID7023302 TK.Half.Life NA 3.11 hours 1compartment NA NA Human Human +DTXSID7023302 Css NA 0.1301 mg/L 3compartmentss NA 50% Human Human +DTXSID7023302 Css NA 0.8763 mg/L 3compartmentss NA 95% Human Human +DTXSID7023302 Css NA 0.09434 mg/L PBTK NA 50% Human Human +DTXSID7023302 Css NA 0.5888 mg/L PBTK NA 95% Human Human +DTXSID7023302 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023302 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023302 Vd NA 1.319 L/kg 1compartment NA NA Rat Human DTXSID7023302 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023302 TK.Half.Life NA 1.268 hours 1compartment NA NA Rat Human -DTXSID7023302 Css NA 0.1012 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023302 Css NA 0.5276 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023302 Css NA 0.06734 mg/L PBTK NA 50% Rat Human -DTXSID7023302 Css NA 0.327 mg/L PBTK NA 95% Rat Human -DTXSID7023350 Clint NA 2.036 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023350 Fup NA 0.135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023350 Vd NA 1.574 L/kg 1compartment NA NA Human Human -DTXSID7023350 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7023350 TK.Half.Life NA 22.4 hours 1compartment NA NA Human Human -DTXSID7023350 Css NA 1.926 mg/L 3compartmentss NA 50% Human Human -DTXSID7023350 Css NA 10.54 mg/L 3compartmentss NA 95% Human Human -DTXSID7023350 Css NA 1.315 mg/L PBTK NA 50% Human Human -DTXSID7023350 Css NA 6.633 mg/L PBTK NA 95% Human Human -DTXSID7023350 Clint NA 2.036 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023350 Fup NA 0.135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023350 Vd NA 1.214 L/kg 1compartment NA NA Rat Human -DTXSID7023350 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7023350 TK.Half.Life NA 7.671 hours 1compartment NA NA Rat Human -DTXSID7023350 Css NA 0.901 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023350 Css NA 3.736 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023350 Css NA 0.5843 mg/L PBTK NA 50% Rat Human -DTXSID7023350 Css NA 2.161 mg/L PBTK NA 95% Rat Human -DTXSID7023352 Clint NA 270.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023352 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023352 Vd NA 220.4 L/kg 1compartment NA NA Human Human -DTXSID7023352 Days.Css NA 115 Days PBTK NA NA Human Human -DTXSID7023352 TK.Half.Life NA 528.7 hours 1compartment NA NA Human Human -DTXSID7023352 Css NA 0.006694 mg/L 3compartmentss NA 50% Human Human -DTXSID7023352 Css NA 0.04081 mg/L 3compartmentss NA 95% Human Human -DTXSID7023352 Css NA 0.1985 mg/L PBTK NA 50% Human Human -DTXSID7023352 Css NA 1.081 mg/L PBTK NA 95% Human Human -DTXSID7023352 Clint NA 270.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023352 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023352 Vd NA 195.1 L/kg 1compartment NA NA Rat Human -DTXSID7023352 Days.Css NA 81 Days PBTK NA NA Rat Human -DTXSID7023352 TK.Half.Life NA 83.07 hours 1compartment NA NA Rat Human -DTXSID7023352 Css NA 0.003378 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023352 Css NA 0.01471 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023352 Css NA 0.1072 mg/L PBTK NA 50% Rat Human -DTXSID7023352 Css NA 0.4857 mg/L PBTK NA 95% Rat Human -DTXSID7023356 Clint NA 1.031 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7023302 TK.Half.Life NA 1.161 hours 1compartment NA NA Rat Human +DTXSID7023302 Css NA 0.01644 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023302 Css NA 0.08376 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023302 Css NA 0.01184 mg/L PBTK NA 50% Rat Human +DTXSID7023302 Css NA 0.05664 mg/L PBTK NA 95% Rat Human +DTXSID7023350 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023350 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023350 Vd NA 1.704 L/kg 1compartment NA NA Human Human +DTXSID7023350 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023350 TK.Half.Life NA 3.656 hours 1compartment NA NA Human Human +DTXSID7023350 Css NA 0.1784 mg/L 3compartmentss NA 50% Human Human +DTXSID7023350 Css NA 1.272 mg/L 3compartmentss NA 95% Human Human +DTXSID7023350 Css NA 0.1247 mg/L PBTK NA 50% Human Human +DTXSID7023350 Css NA 0.8629 mg/L PBTK NA 95% Human Human +DTXSID7023350 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023350 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023350 Vd NA 1.317 L/kg 1compartment NA NA Rat Human +DTXSID7023350 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023350 TK.Half.Life NA 1.352 hours 1compartment NA NA Rat Human +DTXSID7023350 Css NA 0.02281 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023350 Css NA 0.1272 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023350 Css NA 0.01582 mg/L PBTK NA 50% Rat Human +DTXSID7023350 Css NA 0.0828 mg/L PBTK NA 95% Rat Human +DTXSID7023352 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023352 Fup 0.0583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023352 Vd NA 1.074 L/kg 1compartment NA NA Human Human +DTXSID7023352 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023352 TK.Half.Life NA 4.196 hours 1compartment NA NA Human Human +DTXSID7023352 Css NA 0.5005 mg/L 3compartmentss NA 50% Human Human +DTXSID7023352 Css NA 3.914 mg/L 3compartmentss NA 95% Human Human +DTXSID7023352 Css NA 0.3183 mg/L PBTK NA 50% Human Human +DTXSID7023352 Css NA 2.403 mg/L PBTK NA 95% Human Human +DTXSID7023352 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023352 Fup 0.0583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023352 Vd NA 0.8213 L/kg 1compartment NA NA Rat Human +DTXSID7023352 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023352 TK.Half.Life NA 1.806 hours 1compartment NA NA Rat Human +DTXSID7023352 Css NA 0.06603 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023352 Css NA 0.4121 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023352 Css NA 0.04051 mg/L PBTK NA 50% Rat Human +DTXSID7023352 Css NA 0.242 mg/L PBTK NA 95% Rat Human +DTXSID7023354 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023354 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7023354 Vd NA 1.605 L/kg 1compartment NA NA Human Human +DTXSID7023354 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023354 TK.Half.Life NA 2.282 hours 1compartment NA NA Human Human +DTXSID7023354 Css NA 0.09823 mg/L 3compartmentss NA 50% Human Human +DTXSID7023354 Css NA 0.854 mg/L 3compartmentss NA 95% Human Human +DTXSID7023354 Css NA 0.08791 mg/L PBTK NA 50% Human Human +DTXSID7023354 Css NA 0.6173 mg/L PBTK NA 95% Human Human +DTXSID7023354 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023354 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7023354 Vd NA 1.397 L/kg 1compartment NA NA Rat Human +DTXSID7023354 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023354 TK.Half.Life NA 0.9828 hours 1compartment NA NA Rat Human +DTXSID7023354 Css NA 0.01074 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023354 Css NA 0.08442 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023354 Css NA 0.00987 mg/L PBTK NA 50% Rat Human +DTXSID7023354 Css NA 0.05644 mg/L PBTK NA 95% Rat Human +DTXSID7023356 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7023356 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7023356 Vd NA 0.4074 L/kg 1compartment NA NA Human Human DTXSID7023356 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023356 TK.Half.Life NA 8.99 hours 1compartment NA NA Human Human -DTXSID7023356 Css NA 3.256 mg/L 3compartmentss NA 50% Human Human -DTXSID7023356 Css NA 18.24 mg/L 3compartmentss NA 95% Human Human -DTXSID7023356 Css NA 2.119 mg/L PBTK NA 50% Human Human -DTXSID7023356 Css NA 10.85 mg/L PBTK NA 95% Human Human -DTXSID7023356 Clint NA 1.031 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7023356 TK.Half.Life NA 2.403 hours 1compartment NA NA Human Human +DTXSID7023356 Css NA 0.4336 mg/L 3compartmentss NA 50% Human Human +DTXSID7023356 Css NA 3.155 mg/L 3compartmentss NA 95% Human Human +DTXSID7023356 Css NA 0.2806 mg/L PBTK NA 50% Human Human +DTXSID7023356 Css NA 1.922 mg/L PBTK NA 95% Human Human +DTXSID7023356 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7023356 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7023356 Vd NA 0.403 L/kg 1compartment NA NA Rat Human DTXSID7023356 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023356 TK.Half.Life NA 4.449 hours 1compartment NA NA Rat Human -DTXSID7023356 Css NA 1.372 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023356 Css NA 6 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023356 Css NA 0.8343 mg/L PBTK NA 50% Rat Human -DTXSID7023356 Css NA 3.353 mg/L PBTK NA 95% Rat Human +DTXSID7023356 TK.Half.Life NA 1.446 hours 1compartment NA NA Rat Human +DTXSID7023356 Css NA 0.004396 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023356 Css NA 0.02896 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023356 Css NA 0.002691 mg/L PBTK NA 50% Rat Human +DTXSID7023356 Css NA 0.01648 mg/L PBTK NA 95% Rat Human +DTXSID7023431 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023431 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7023431 Vd NA 2.975 L/kg 1compartment NA NA Human Human +DTXSID7023431 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7023431 TK.Half.Life NA 34.23 hours 1compartment NA NA Human Human +DTXSID7023431 Css NA 1.186 mg/L 3compartmentss NA 50% Human Human +DTXSID7023431 Css NA 7.444 mg/L 3compartmentss NA 95% Human Human +DTXSID7023431 Css NA 0.8796 mg/L PBTK NA 50% Human Human +DTXSID7023431 Css NA 5.201 mg/L PBTK NA 95% Human Human +DTXSID7023431 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023431 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7023431 Vd NA 2.379 L/kg 1compartment NA NA Rat Human +DTXSID7023431 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7023431 TK.Half.Life NA 8.557 hours 1compartment NA NA Rat Human +DTXSID7023431 Css NA 0.05668 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023431 Css NA 0.3846 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023431 Css NA 0.04136 mg/L PBTK NA 50% Rat Human +DTXSID7023431 Css NA 0.2586 mg/L PBTK NA 95% Rat Human +DTXSID7023433 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023433 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7023433 Vd NA 7.427 L/kg 1compartment NA NA Human Human +DTXSID7023433 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023433 TK.Half.Life NA 5.303 hours 1compartment NA NA Human Human +DTXSID7023433 Css NA 0.01641 mg/L 3compartmentss NA 50% Human Human +DTXSID7023433 Css NA 0.1276 mg/L 3compartmentss NA 95% Human Human +DTXSID7023433 Css NA 0.01732 mg/L PBTK NA 50% Human Human +DTXSID7023433 Css NA 0.1346 mg/L PBTK NA 95% Human Human +DTXSID7023433 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023433 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7023433 Vd NA 8.536 L/kg 1compartment NA NA Rat Human +DTXSID7023433 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023433 TK.Half.Life NA 2.217 hours 1compartment NA NA Rat Human +DTXSID7023433 Css NA 0.001705 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023433 Css NA 0.01105 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023433 Css NA 0.001877 mg/L PBTK NA 50% Rat Human +DTXSID7023433 Css NA 0.01214 mg/L PBTK NA 95% Rat Human DTXSID7023435 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID7023435 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7023435 Vd NA 1.305 L/kg 1compartment NA NA Human Human DTXSID7023435 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID7023435 TK.Half.Life NA 12.36 hours 1compartment NA NA Human Human -DTXSID7023435 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human -DTXSID7023435 Css NA 4.569 mg/L 3compartmentss NA 95% Human Human -DTXSID7023435 Css NA 0.7738 mg/L PBTK NA 50% Human Human -DTXSID7023435 Css NA 2.876 mg/L PBTK NA 95% Human Human +DTXSID7023435 Css NA 1.079 mg/L 3compartmentss NA 50% Human Human +DTXSID7023435 Css NA 4.382 mg/L 3compartmentss NA 95% Human Human +DTXSID7023435 Css NA 0.755 mg/L PBTK NA 50% Human Human +DTXSID7023435 Css NA 2.769 mg/L PBTK NA 95% Human Human DTXSID7023435 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID7023435 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7023435 Vd NA 1.089 L/kg 1compartment NA NA Rat Human DTXSID7023435 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7023435 TK.Half.Life NA 3.515 hours 1compartment NA NA Rat Human -DTXSID7023435 Css NA 0.368 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023435 Css NA 1.372 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023435 Css NA 0.2513 mg/L PBTK NA 50% Rat Human -DTXSID7023435 Css NA 0.8038 mg/L PBTK NA 95% Rat Human -DTXSID7023437 Clint NA 6.672 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7023435 Css NA 0.08226 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023435 Css NA 0.3054 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023435 Css NA 0.05814 mg/L PBTK NA 50% Rat Human +DTXSID7023435 Css NA 0.1858 mg/L PBTK NA 95% Rat Human +DTXSID7023437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7023437 Fup 0.51 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7023437 Vd NA 0.6842 L/kg 1compartment NA NA Human Human DTXSID7023437 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023437 TK.Half.Life NA 1.117 hours 1compartment NA NA Human Human -DTXSID7023437 Css NA 0.1266 mg/L 3compartmentss NA 50% Human Human -DTXSID7023437 Css NA 0.9489 mg/L 3compartmentss NA 95% Human Human -DTXSID7023437 Css NA 0.09722 mg/L PBTK NA 50% Human Human -DTXSID7023437 Css NA 0.6283 mg/L PBTK NA 95% Human Human -DTXSID7023437 Clint NA 6.672 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7023437 TK.Half.Life NA 8.743 hours 1compartment NA NA Human Human +DTXSID7023437 Css NA 1.362 mg/L 3compartmentss NA 50% Human Human +DTXSID7023437 Css NA 7.494 mg/L 3compartmentss NA 95% Human Human +DTXSID7023437 Css NA 1.063 mg/L PBTK NA 50% Human Human +DTXSID7023437 Css NA 4.779 mg/L PBTK NA 95% Human Human +DTXSID7023437 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7023437 Fup 0.51 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7023437 Vd NA 0.6797 L/kg 1compartment NA NA Rat Human DTXSID7023437 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023437 TK.Half.Life NA 0.6048 hours 1compartment NA NA Rat Human -DTXSID7023437 Css NA 0.06259 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023437 Css NA 0.382 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023437 Css NA 0.04664 mg/L PBTK NA 50% Rat Human -DTXSID7023437 Css NA 0.2343 mg/L PBTK NA 95% Rat Human -DTXSID7023481 Clint NA 40.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023481 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023481 Vd NA 3.05 L/kg 1compartment NA NA Human Human -DTXSID7023481 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7023481 TK.Half.Life NA 23.71 hours 1compartment NA NA Human Human -DTXSID7023481 Css NA 0.8858 mg/L 3compartmentss NA 50% Human Human -DTXSID7023481 Css NA 5.68 mg/L 3compartmentss NA 95% Human Human -DTXSID7023481 Css NA 0.6184 mg/L PBTK NA 50% Human Human -DTXSID7023481 Css NA 3.816 mg/L PBTK NA 95% Human Human -DTXSID7023481 Clint NA 40.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023481 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023481 Vd NA 2.288 L/kg 1compartment NA NA Rat Human -DTXSID7023481 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7023481 TK.Half.Life NA 3.874 hours 1compartment NA NA Rat Human -DTXSID7023481 Css NA 0.5001 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023481 Css NA 2.642 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023481 Css NA 0.3328 mg/L PBTK NA 50% Rat Human -DTXSID7023481 Css NA 1.744 mg/L PBTK NA 95% Rat Human -DTXSID7023485 Clint NA 1.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023485 Fup NA 0.5388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023485 Vd NA 0.7378 L/kg 1compartment NA NA Human Human +DTXSID7023437 TK.Half.Life NA 2.943 hours 1compartment NA NA Rat Human +DTXSID7023437 Css NA 0.0856 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023437 Css NA 0.4148 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023437 Css NA 0.06634 mg/L PBTK NA 50% Rat Human +DTXSID7023437 Css NA 0.2554 mg/L PBTK NA 95% Rat Human +DTXSID7023481 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023481 Fup 0.0669 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023481 Vd NA 3.064 L/kg 1compartment NA NA Human Human +DTXSID7023481 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID7023481 TK.Half.Life NA 47.94 hours 1compartment NA NA Human Human +DTXSID7023481 Css NA 1.832 mg/L 3compartmentss NA 50% Human Human +DTXSID7023481 Css NA 12.03 mg/L 3compartmentss NA 95% Human Human +DTXSID7023481 Css NA 1.279 mg/L PBTK NA 50% Human Human +DTXSID7023481 Css NA 8.068 mg/L PBTK NA 95% Human Human +DTXSID7023481 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023481 Fup 0.0669 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023481 Vd NA 2.298 L/kg 1compartment NA NA Rat Human +DTXSID7023481 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7023481 TK.Half.Life NA 7.201 hours 1compartment NA NA Rat Human +DTXSID7023481 Css NA 0.2372 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023481 Css NA 1.299 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023481 Css NA 0.163 mg/L PBTK NA 50% Rat Human +DTXSID7023481 Css NA 0.8831 mg/L PBTK NA 95% Rat Human +DTXSID7023485 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023485 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023485 Vd NA 0.7025 L/kg 1compartment NA NA Human Human DTXSID7023485 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023485 TK.Half.Life NA 3.531 hours 1compartment NA NA Human Human -DTXSID7023485 Css NA 0.5032 mg/L 3compartmentss NA 50% Human Human -DTXSID7023485 Css NA 3.227 mg/L 3compartmentss NA 95% Human Human -DTXSID7023485 Css NA 0.3965 mg/L PBTK NA 50% Human Human -DTXSID7023485 Css NA 2.052 mg/L PBTK NA 95% Human Human -DTXSID7023485 Clint NA 1.012 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023485 Fup NA 0.5388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023485 Vd NA 0.7271 L/kg 1compartment NA NA Rat Human +DTXSID7023485 TK.Half.Life NA 9.269 hours 1compartment NA NA Human Human +DTXSID7023485 Css NA 1.383 mg/L 3compartmentss NA 50% Human Human +DTXSID7023485 Css NA 7.323 mg/L 3compartmentss NA 95% Human Human +DTXSID7023485 Css NA 1.085 mg/L PBTK NA 50% Human Human +DTXSID7023485 Css NA 4.63 mg/L PBTK NA 95% Human Human +DTXSID7023485 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023485 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023485 Vd NA 0.6911 L/kg 1compartment NA NA Rat Human DTXSID7023485 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023485 TK.Half.Life NA 1.684 hours 1compartment NA NA Rat Human -DTXSID7023485 Css NA 0.1978 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023485 Css NA 1.172 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023485 Css NA 0.152 mg/L PBTK NA 50% Rat Human -DTXSID7023485 Css NA 0.6941 mg/L PBTK NA 95% Rat Human +DTXSID7023485 TK.Half.Life NA 3.085 hours 1compartment NA NA Rat Human +DTXSID7023485 Css NA 0.08727 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023485 Css NA 0.3946 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023485 Css NA 0.06768 mg/L PBTK NA 50% Rat Human +DTXSID7023485 Css NA 0.2441 mg/L PBTK NA 95% Rat Human DTXSID7023487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID7023487 Fup 0.89 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human -DTXSID7023487 Vd NA 4.416 L/kg 1compartment NA NA Human Human -DTXSID7023487 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID7023487 TK.Half.Life NA 51.5 hours 1compartment NA NA Human Human -DTXSID7023487 Css NA 0.4304 mg/L 3compartmentss NA 50% Human Human -DTXSID7023487 Css NA 2.083 mg/L 3compartmentss NA 95% Human Human -DTXSID7023487 Css NA 0.3541 mg/L PBTK NA 50% Human Human -DTXSID7023487 Css NA 1.389 mg/L PBTK NA 95% Human Human +DTXSID7023487 Vd NA 2.274 L/kg 1compartment NA NA Human Human +DTXSID7023487 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7023487 TK.Half.Life NA 16.67 hours 1compartment NA NA Human Human +DTXSID7023487 Css NA 0.7469 mg/L 3compartmentss NA 50% Human Human +DTXSID7023487 Css NA 3.437 mg/L 3compartmentss NA 95% Human Human +DTXSID7023487 Css NA 0.7469 mg/L PBTK NA 50% Human Human +DTXSID7023487 Css NA 3.436 mg/L PBTK NA 95% Human Human DTXSID7023487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID7023487 Fup 0.89 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human -DTXSID7023487 Vd NA 4.223 L/kg 1compartment NA NA Rat Human -DTXSID7023487 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7023487 TK.Half.Life NA 11.97 hours 1compartment NA NA Rat Human -DTXSID7023487 Css NA 0.3337 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023487 Css NA 1.592 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023487 Css NA 0.2661 mg/L PBTK NA 50% Rat Human -DTXSID7023487 Css NA 0.9718 mg/L PBTK NA 95% Rat Human -DTXSID7023510 Clint NA 15.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023510 Fup NA 0.6126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023510 Vd NA 0.9369 L/kg 1compartment NA NA Human Human +DTXSID7023487 Vd NA 2.303 L/kg 1compartment NA NA Rat Human +DTXSID7023487 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023487 TK.Half.Life NA 5.719 hours 1compartment NA NA Rat Human +DTXSID7023487 Css NA 0.04347 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023487 Css NA 0.1793 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023487 Css NA 0.045 mg/L PBTK NA 50% Rat Human +DTXSID7023487 Css NA 0.1857 mg/L PBTK NA 95% Rat Human +DTXSID7023510 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023510 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023510 Vd NA 0.6585 L/kg 1compartment NA NA Human Human DTXSID7023510 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023510 TK.Half.Life NA 0.9184 hours 1compartment NA NA Human Human -DTXSID7023510 Css NA 0.04748 mg/L 3compartmentss NA 50% Human Human -DTXSID7023510 Css NA 0.4964 mg/L 3compartmentss NA 95% Human Human -DTXSID7023510 Css NA 0.03878 mg/L PBTK NA 50% Human Human -DTXSID7023510 Css NA 0.338 mg/L PBTK NA 95% Human Human -DTXSID7023510 Clint NA 15.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023510 Fup NA 0.6126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023510 Vd NA 0.8852 L/kg 1compartment NA NA Rat Human +DTXSID7023510 TK.Half.Life NA 1.546 hours 1compartment NA NA Human Human +DTXSID7023510 Css NA 0.1976 mg/L 3compartmentss NA 50% Human Human +DTXSID7023510 Css NA 1.254 mg/L 3compartmentss NA 95% Human Human +DTXSID7023510 Css NA 0.1434 mg/L PBTK NA 50% Human Human +DTXSID7023510 Css NA 0.8387 mg/L PBTK NA 95% Human Human +DTXSID7023510 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023510 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023510 Vd NA 0.6193 L/kg 1compartment NA NA Rat Human DTXSID7023510 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023510 TK.Half.Life NA 0.4393 hours 1compartment NA NA Rat Human -DTXSID7023510 Css NA 0.02432 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023510 Css NA 0.2116 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023510 Css NA 0.01951 mg/L PBTK NA 50% Rat Human -DTXSID7023510 Css NA 0.1341 mg/L PBTK NA 95% Rat Human +DTXSID7023510 TK.Half.Life 0.66 0.818 hours 1compartment National Toxicology Program NA Rat Human +DTXSID7023510 Css NA 0.02341 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023510 Css NA 0.1115 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023510 Css NA 0.0168 mg/L PBTK NA 50% Rat Human +DTXSID7023510 Css NA 0.07124 mg/L PBTK NA 95% Rat Human DTXSID7023512 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID7023512 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7023512 Vd NA 1.713 L/kg 1compartment NA NA Human Human DTXSID7023512 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7023512 TK.Half.Life NA 6.245 hours 1compartment NA NA Human Human -DTXSID7023512 Css NA 0.3333 mg/L 3compartmentss NA 50% Human Human -DTXSID7023512 Css NA 2.192 mg/L 3compartmentss NA 95% Human Human -DTXSID7023512 Css NA 0.307 mg/L PBTK NA 50% Human Human -DTXSID7023512 Css NA 1.491 mg/L PBTK NA 95% Human Human +DTXSID7023512 Css NA 0.3517 mg/L 3compartmentss NA 50% Human Human +DTXSID7023512 Css NA 1.688 mg/L 3compartmentss NA 95% Human Human +DTXSID7023512 Css NA 0.3505 mg/L PBTK NA 50% Human Human +DTXSID7023512 Css NA 1.686 mg/L PBTK NA 95% Human Human DTXSID7023512 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID7023512 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7023512 Vd NA 1.86 L/kg 1compartment NA NA Rat Human DTXSID7023512 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7023512 TK.Half.Life NA 2.867 hours 1compartment NA NA Rat Human -DTXSID7023512 Css NA 0.1335 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023512 Css NA 0.7777 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023512 Css NA 0.1202 mg/L PBTK NA 50% Rat Human -DTXSID7023512 Css NA 0.4918 mg/L PBTK NA 95% Rat Human +DTXSID7023512 Css NA 0.02728 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023512 Css NA 0.1167 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023512 Css NA 0.02825 mg/L PBTK NA 50% Rat Human +DTXSID7023512 Css NA 0.1208 mg/L PBTK NA 95% Rat Human DTXSID7023514 Clint 5.452 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7023514 Fup 0.0027 NA NA https://doi.org/10.1124/dmd.117.077040 NA Human Human -DTXSID7023514 Vd NA 2.248 L/kg 1compartment NA NA Human Human -DTXSID7023514 Days.Css NA 54 Days PBTK NA NA Human Human -DTXSID7023514 TK.Half.Life NA 250.6 hours 1compartment NA NA Human Human -DTXSID7023514 Css NA 17.87 mg/L 3compartmentss NA 50% Human Human -DTXSID7023514 Css NA 125.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7023514 Css NA 11.46 mg/L PBTK NA 50% Human Human -DTXSID7023514 Css NA 77.91 mg/L PBTK NA 95% Human Human +DTXSID7023514 Vd NA 2.407 L/kg 1compartment NA NA Human Human +DTXSID7023514 Days.Css NA 58 Days PBTK NA NA Human Human +DTXSID7023514 TK.Half.Life NA 266.8 hours 1compartment NA NA Human Human +DTXSID7023514 Css NA 16.69 mg/L 3compartmentss NA 50% Human Human +DTXSID7023514 Css NA 124.3 mg/L 3compartmentss NA 95% Human Human +DTXSID7023514 Css NA 10.86 mg/L PBTK NA 50% Human Human +DTXSID7023514 Css NA 77.65 mg/L PBTK NA 95% Human Human DTXSID7023514 Clint 5.452 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID7023514 Fup 0.0027 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human -DTXSID7023514 Vd NA 1.666 L/kg 1compartment NA NA Rat Human -DTXSID7023514 Days.Css NA 28 Days PBTK NA NA Rat Human -DTXSID7023514 TK.Half.Life NA 69.57 hours 1compartment NA NA Rat Human -DTXSID7023514 Css NA 9.894 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023514 Css NA 55.28 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023514 Css NA 6.008 mg/L PBTK NA 50% Rat Human -DTXSID7023514 Css NA 32.39 mg/L PBTK NA 95% Rat Human -DTXSID7023516 Clint NA 8.659 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023516 Fup NA 0.1214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023516 Vd NA 0.3107 L/kg 1compartment NA NA Human Human +DTXSID7023514 Vd NA 1.788 L/kg 1compartment NA NA Rat Human +DTXSID7023514 Days.Css NA 30 Days PBTK NA NA Rat Human +DTXSID7023514 TK.Half.Life NA 67.62 hours 1compartment NA NA Rat Human +DTXSID7023514 Css NA 2.166 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023514 Css NA 12.48 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023514 Css NA 1.379 mg/L PBTK NA 50% Rat Human +DTXSID7023514 Css NA 7.619 mg/L PBTK NA 95% Rat Human +DTXSID7023516 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023516 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023516 Vd NA 0.5414 L/kg 1compartment NA NA Human Human DTXSID7023516 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023516 TK.Half.Life NA 1.286 hours 1compartment NA NA Human Human -DTXSID7023516 Css NA 0.5524 mg/L 3compartmentss NA 50% Human Human -DTXSID7023516 Css NA 4.049 mg/L 3compartmentss NA 95% Human Human -DTXSID7023516 Css NA 0.3454 mg/L PBTK NA 50% Human Human -DTXSID7023516 Css NA 2.424 mg/L PBTK NA 95% Human Human -DTXSID7023516 Clint NA 8.659 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023516 Fup NA 0.1214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023516 Vd NA 0.3138 L/kg 1compartment NA NA Rat Human +DTXSID7023516 TK.Half.Life NA 1.113 hours 1compartment NA NA Human Human +DTXSID7023516 Css NA 0.08221 mg/L 3compartmentss NA 50% Human Human +DTXSID7023516 Css NA 0.6282 mg/L 3compartmentss NA 95% Human Human +DTXSID7023516 Css NA 0.06102 mg/L PBTK NA 50% Human Human +DTXSID7023516 Css NA 0.416 mg/L PBTK NA 95% Human Human +DTXSID7023516 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023516 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023516 Vd NA 0.5528 L/kg 1compartment NA NA Rat Human DTXSID7023516 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023516 TK.Half.Life NA 0.7878 hours 1compartment NA NA Rat Human -DTXSID7023516 Css NA 0.2989 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023516 Css NA 1.651 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023516 Css NA 0.1758 mg/L PBTK NA 50% Rat Human -DTXSID7023516 Css NA 0.9186 mg/L PBTK NA 95% Rat Human +DTXSID7023516 TK.Half.Life NA 0.6377 hours 1compartment NA NA Rat Human +DTXSID7023516 Css NA 0.0007691 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023516 Css NA 0.005178 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023516 Css NA 0.0005482 mg/L PBTK NA 50% Rat Human +DTXSID7023516 Css NA 0.003319 mg/L PBTK NA 95% Rat Human DTXSID7023518 Clint 41.28 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7023518 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7023518 Vd NA 3.116 L/kg 1compartment NA NA Human Human -DTXSID7023518 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7023518 TK.Half.Life NA 29.19 hours 1compartment NA NA Human Human -DTXSID7023518 Css NA 1.046 mg/L 3compartmentss NA 50% Human Human -DTXSID7023518 Css NA 6.794 mg/L 3compartmentss NA 95% Human Human -DTXSID7023518 Css NA 0.7354 mg/L PBTK NA 50% Human Human -DTXSID7023518 Css NA 4.643 mg/L PBTK NA 95% Human Human +DTXSID7023518 Vd NA 3.487 L/kg 1compartment NA NA Human Human +DTXSID7023518 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023518 TK.Half.Life NA 14.19 hours 1compartment NA NA Human Human +DTXSID7023518 Css NA 0.3674 mg/L 3compartmentss NA 50% Human Human +DTXSID7023518 Css NA 2.598 mg/L 3compartmentss NA 95% Human Human +DTXSID7023518 Css NA 0.2884 mg/L PBTK NA 50% Human Human +DTXSID7023518 Css NA 1.93 mg/L PBTK NA 95% Human Human DTXSID7023518 Clint 41.28 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID7023518 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7023518 Vd NA 2.344 L/kg 1compartment NA NA Rat Human -DTXSID7023518 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7023518 TK.Half.Life NA 4.415 hours 1compartment NA NA Rat Human -DTXSID7023518 Css NA 0.587 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023518 Css NA 3.127 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023518 Css NA 0.3983 mg/L PBTK NA 50% Rat Human -DTXSID7023518 Css NA 2.052 mg/L PBTK NA 95% Rat Human -DTXSID7023566 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023566 Fup NA 0.5719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023566 Vd NA 3.188 L/kg 1compartment NA NA Human Human -DTXSID7023566 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID7023566 TK.Half.Life NA 16860 hours 1compartment NA NA Human Human -DTXSID7023566 Css NA 586.6 mg/L 3compartmentss NA 50% Human Human -DTXSID7023566 Css NA 1671 mg/L 3compartmentss NA 95% Human Human -DTXSID7023566 Css NA 416.7 mg/L PBTK NA 50% Human Human -DTXSID7023566 Css NA 1103 mg/L PBTK NA 95% Human Human -DTXSID7023566 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023566 Fup NA 0.5719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023566 Vd NA 2.408 L/kg 1compartment NA NA Rat Human -DTXSID7023566 Days.Css NA 1198 Days PBTK NA NA Rat Human -DTXSID7023566 TK.Half.Life NA 1041 hours 1compartment NA NA Rat Human -DTXSID7023566 Css NA 159.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023566 Css NA 349.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023566 Css NA 108 mg/L PBTK NA 50% Rat Human -DTXSID7023566 Css NA 213 mg/L PBTK NA 95% Rat Human -DTXSID7023568 Clint NA 19.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7023518 Vd NA 2.794 L/kg 1compartment NA NA Rat Human +DTXSID7023518 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023518 TK.Half.Life NA 2.825 hours 1compartment NA NA Rat Human +DTXSID7023518 Css NA 0.04729 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023518 Css NA 0.2736 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023518 Css NA 0.03747 mg/L PBTK NA 50% Rat Human +DTXSID7023518 Css NA 0.2097 mg/L PBTK NA 95% Rat Human +DTXSID7023564 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023564 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7023564 Vd NA 3.13 L/kg 1compartment NA NA Human Human +DTXSID7023564 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023564 TK.Half.Life NA 3.739 hours 1compartment NA NA Human Human +DTXSID7023564 Css NA 0.06327 mg/L 3compartmentss NA 50% Human Human +DTXSID7023564 Css NA 0.7891 mg/L 3compartmentss NA 95% Human Human +DTXSID7023564 Css NA 0.08164 mg/L PBTK NA 50% Human Human +DTXSID7023564 Css NA 0.6485 mg/L PBTK NA 95% Human Human +DTXSID7023564 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023564 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7023564 Vd NA 3.11 L/kg 1compartment NA NA Rat Human +DTXSID7023564 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023564 TK.Half.Life NA 2.12 hours 1compartment NA NA Rat Human +DTXSID7023564 Css NA 0.006981 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023564 Css NA 0.07658 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023564 Css NA 0.009454 mg/L PBTK NA 50% Rat Human +DTXSID7023564 Css NA 0.05842 mg/L PBTK NA 95% Rat Human +DTXSID7023566 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023566 Fup 0.0933 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023566 Vd NA 3.142 L/kg 1compartment NA NA Human Human +DTXSID7023566 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7023566 TK.Half.Life NA 18.76 hours 1compartment NA NA Human Human +DTXSID7023566 Css NA 0.6294 mg/L 3compartmentss NA 50% Human Human +DTXSID7023566 Css NA 4.348 mg/L 3compartmentss NA 95% Human Human +DTXSID7023566 Css NA 0.4562 mg/L PBTK NA 50% Human Human +DTXSID7023566 Css NA 2.967 mg/L PBTK NA 95% Human Human +DTXSID7023566 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023566 Fup 0.0933 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023566 Vd NA 2.43 L/kg 1compartment NA NA Rat Human +DTXSID7023566 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023566 TK.Half.Life NA 3.631 hours 1compartment NA NA Rat Human +DTXSID7023566 Css NA 0.08162 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023566 Css NA 0.4553 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023566 Css NA 0.05872 mg/L PBTK NA 50% Rat Human +DTXSID7023566 Css NA 0.318 mg/L PBTK NA 95% Rat Human +DTXSID7023568 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7023568 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7023568 Vd NA 0.3865 L/kg 1compartment NA NA Human Human -DTXSID7023568 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023568 TK.Half.Life NA 0.4281 hours 1compartment NA NA Human Human -DTXSID7023568 Css NA 0.05115 mg/L 3compartmentss NA 50% Human Human -DTXSID7023568 Css NA 0.4343 mg/L 3compartmentss NA 95% Human Human -DTXSID7023568 Css NA 0.03558 mg/L PBTK NA 50% Human Human -DTXSID7023568 Css NA 0.2761 mg/L PBTK NA 95% Human Human -DTXSID7023568 Clint NA 19.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7023568 Vd NA 0.7592 L/kg 1compartment NA NA Human Human +DTXSID7023568 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7023568 TK.Half.Life NA 9.908 hours 1compartment NA NA Human Human +DTXSID7023568 Css NA 1.221 mg/L 3compartmentss NA 50% Human Human +DTXSID7023568 Css NA 6.304 mg/L 3compartmentss NA 95% Human Human +DTXSID7023568 Css NA 0.9567 mg/L PBTK NA 50% Human Human +DTXSID7023568 Css NA 4.032 mg/L PBTK NA 95% Human Human +DTXSID7023568 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7023568 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7023568 Vd NA 0.3969 L/kg 1compartment NA NA Rat Human +DTXSID7023568 Vd NA 0.7495 L/kg 1compartment NA NA Rat Human DTXSID7023568 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023568 TK.Half.Life NA 0.2212 hours 1compartment NA NA Rat Human -DTXSID7023568 Css NA 0.02726 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023568 Css NA 0.1772 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023568 Css NA 0.01805 mg/L PBTK NA 50% Rat Human -DTXSID7023568 Css NA 0.1089 mg/L PBTK NA 95% Rat Human -DTXSID7023643 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023643 Fup NA 0.4924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023643 Vd NA 2.636 L/kg 1compartment NA NA Human Human -DTXSID7023643 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID7023643 TK.Half.Life NA 104.6 hours 1compartment NA NA Human Human -DTXSID7023643 Css NA 4.183 mg/L 3compartmentss NA 50% Human Human -DTXSID7023643 Css NA 14.28 mg/L 3compartmentss NA 95% Human Human -DTXSID7023643 Css NA 3.318 mg/L PBTK NA 50% Human Human -DTXSID7023643 Css NA 9.735 mg/L PBTK NA 95% Human Human -DTXSID7023643 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023643 Fup NA 0.4924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023643 Vd NA 2.049 L/kg 1compartment NA NA Rat Human -DTXSID7023643 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID7023643 TK.Half.Life NA 13.59 hours 1compartment NA NA Rat Human -DTXSID7023643 Css NA 1.11 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023643 Css NA 3.135 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023643 Css NA 0.8556 mg/L PBTK NA 50% Rat Human -DTXSID7023643 Css NA 2.002 mg/L PBTK NA 95% Rat Human +DTXSID7023568 TK.Half.Life NA 3.312 hours 1compartment NA NA Rat Human +DTXSID7023568 Css NA 0.0302 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023568 Css NA 0.1996 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023568 Css NA 0.02363 mg/L PBTK NA 50% Rat Human +DTXSID7023568 Css NA 0.1293 mg/L PBTK NA 95% Rat Human +DTXSID70236238 Clint 28.84 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70236238 Fup 0.0848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70236238 Vd NA 2.265 L/kg 1compartment NA NA Human Human +DTXSID70236238 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70236238 TK.Half.Life NA 7.48 hours 1compartment NA NA Human Human +DTXSID70236238 Css NA 0.3073 mg/L 3compartmentss NA 50% Human Human +DTXSID70236238 Css NA 2.173 mg/L 3compartmentss NA 95% Human Human +DTXSID70236238 Css NA 0.21 mg/L PBTK NA 50% Human Human +DTXSID70236238 Css NA 1.421 mg/L PBTK NA 95% Human Human +DTXSID70236238 Clint 28.84 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70236238 Fup 0.0848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70236238 Vd NA 1.724 L/kg 1compartment NA NA Rat Human +DTXSID70236238 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70236238 TK.Half.Life NA 2.304 hours 1compartment NA NA Rat Human +DTXSID70236238 Css NA 0.0154 mg/L 3compartmentss NA 50% Rat Human +DTXSID70236238 Css NA 0.1174 mg/L 3compartmentss NA 95% Rat Human +DTXSID70236238 Css NA 0.01019 mg/L PBTK NA 50% Rat Human +DTXSID70236238 Css NA 0.07369 mg/L PBTK NA 95% Rat Human +DTXSID7023643 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023643 Fup 0.514 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023643 Vd NA 1.659 L/kg 1compartment NA NA Human Human +DTXSID7023643 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7023643 TK.Half.Life NA 27.1 hours 1compartment NA NA Human Human +DTXSID7023643 Css NA 1.611 mg/L 3compartmentss NA 50% Human Human +DTXSID7023643 Css NA 7.95 mg/L 3compartmentss NA 95% Human Human +DTXSID7023643 Css NA 1.36 mg/L PBTK NA 50% Human Human +DTXSID7023643 Css NA 5.272 mg/L PBTK NA 95% Human Human +DTXSID7023643 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023643 Fup 0.514 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023643 Vd NA 1.383 L/kg 1compartment NA NA Rat Human +DTXSID7023643 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023643 TK.Half.Life NA 6.353 hours 1compartment NA NA Rat Human +DTXSID7023643 Css NA 0.09913 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023643 Css NA 0.4407 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023643 Css NA 0.08398 mg/L PBTK NA 50% Rat Human +DTXSID7023643 Css NA 0.284 mg/L PBTK NA 95% Rat Human DTXSID7023645 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7023645 Fup 0.468 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7023645 Vd NA 0.7349 L/kg 1compartment NA NA Human Human DTXSID7023645 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID7023645 TK.Half.Life NA 10.16 hours 1compartment NA NA Human Human -DTXSID7023645 Css NA 0.4822 mg/L 3compartmentss NA 50% Human Human -DTXSID7023645 Css NA 1.808 mg/L 3compartmentss NA 95% Human Human -DTXSID7023645 Css NA 0.8254 mg/L PBTK NA 50% Human Human -DTXSID7023645 Css NA 2.211 mg/L PBTK NA 95% Human Human +DTXSID7023645 Css NA 0.3336 mg/L 3compartmentss NA 50% Human Human +DTXSID7023645 Css NA 0.9757 mg/L 3compartmentss NA 95% Human Human +DTXSID7023645 Css NA 0.5672 mg/L PBTK NA 50% Human Human +DTXSID7023645 Css NA 1.659 mg/L PBTK NA 95% Human Human DTXSID7023645 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7023645 Fup 0.468 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7023645 Vd NA 0.7367 L/kg 1compartment NA NA Rat Human DTXSID7023645 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7023645 TK.Half.Life NA 3.471 hours 1compartment NA NA Rat Human -DTXSID7023645 Css NA 0.155 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023645 Css NA 0.4943 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023645 Css NA 0.2743 mg/L PBTK NA 50% Rat Human -DTXSID7023645 Css NA 0.563 mg/L PBTK NA 95% Rat Human -DTXSID7023693 Clint NA 58.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023693 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023693 Vd NA 0.1999 L/kg 1compartment NA NA Human Human +DTXSID7023645 Css NA 0.001677 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023645 Css NA 0.005047 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023645 Css NA 0.002856 mg/L PBTK NA 50% Rat Human +DTXSID7023645 Css NA 0.00861 mg/L PBTK NA 95% Rat Human +DTXSID7023691 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023691 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023691 Vd NA 3.554 L/kg 1compartment NA NA Human Human +DTXSID7023691 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID7023691 TK.Half.Life NA 51.88 hours 1compartment NA NA Human Human +DTXSID7023691 Css NA 0.9686 mg/L 3compartmentss NA 50% Human Human +DTXSID7023691 Css NA 5.822 mg/L 3compartmentss NA 95% Human Human +DTXSID7023691 Css NA 1.191 mg/L PBTK NA 50% Human Human +DTXSID7023691 Css NA 4.626 mg/L PBTK NA 95% Human Human +DTXSID7023691 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023691 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023691 Vd NA 3.616 L/kg 1compartment NA NA Rat Human +DTXSID7023691 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7023691 TK.Half.Life NA 17.73 hours 1compartment NA NA Rat Human +DTXSID7023691 Css NA 0.05844 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023691 Css NA 0.3182 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023691 Css NA 0.07481 mg/L PBTK NA 50% Rat Human +DTXSID7023691 Css NA 0.2473 mg/L PBTK NA 95% Rat Human +DTXSID7023693 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023693 Fup 0.063 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023693 Vd NA 0.3288 L/kg 1compartment NA NA Human Human DTXSID7023693 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023693 TK.Half.Life NA 1.42 hours 1compartment NA NA Human Human -DTXSID7023693 Css NA 1.178 mg/L 3compartmentss NA 50% Human Human -DTXSID7023693 Css NA 12.17 mg/L 3compartmentss NA 95% Human Human -DTXSID7023693 Css NA 0.6933 mg/L PBTK NA 50% Human Human -DTXSID7023693 Css NA 7.142 mg/L PBTK NA 95% Human Human -DTXSID7023693 Clint NA 58.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023693 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023693 Vd NA 0.1957 L/kg 1compartment NA NA Rat Human +DTXSID7023693 TK.Half.Life NA 1.198 hours 1compartment NA NA Human Human +DTXSID7023693 Css NA 0.476 mg/L 3compartmentss NA 50% Human Human +DTXSID7023693 Css NA 3.878 mg/L 3compartmentss NA 95% Human Human +DTXSID7023693 Css NA 0.2958 mg/L PBTK NA 50% Human Human +DTXSID7023693 Css NA 2.33 mg/L PBTK NA 95% Human Human +DTXSID7023693 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023693 Fup 0.063 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023693 Vd NA 0.3232 L/kg 1compartment NA NA Rat Human DTXSID7023693 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023693 TK.Half.Life NA 0.9159 hours 1compartment NA NA Rat Human -DTXSID7023693 Css NA 0.6854 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023693 Css NA 5.917 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023693 Css NA 0.3757 mg/L PBTK NA 50% Rat Human -DTXSID7023693 Css NA 3.202 mg/L PBTK NA 95% Rat Human -DTXSID7023697 Clint NA 556.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023697 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023697 Vd NA 0.206 L/kg 1compartment NA NA Human Human +DTXSID7023693 TK.Half.Life NA 0.7288 hours 1compartment NA NA Rat Human +DTXSID7023693 Css NA 0.06214 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023693 Css NA 0.3655 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023693 Css NA 0.0374 mg/L PBTK NA 50% Rat Human +DTXSID7023693 Css NA 0.2136 mg/L PBTK NA 95% Rat Human +DTXSID7023697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023697 Fup 0.0183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023697 Vd NA 0.2717 L/kg 1compartment NA NA Human Human DTXSID7023697 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023697 TK.Half.Life NA 0.3148 hours 1compartment NA NA Human Human -DTXSID7023697 Css NA 0.1083 mg/L 3compartmentss NA 50% Human Human -DTXSID7023697 Css NA 1.106 mg/L 3compartmentss NA 95% Human Human -DTXSID7023697 Css NA 0.06382 mg/L PBTK NA 50% Human Human -DTXSID7023697 Css NA 0.6465 mg/L PBTK NA 95% Human Human -DTXSID7023697 Clint NA 556.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023697 Fup NA 0.0125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023697 Vd NA 0.1991 L/kg 1compartment NA NA Rat Human +DTXSID7023697 TK.Half.Life NA 2.784 hours 1compartment NA NA Human Human +DTXSID7023697 Css NA 1.717 mg/L 3compartmentss NA 50% Human Human +DTXSID7023697 Css NA 17.75 mg/L 3compartmentss NA 95% Human Human +DTXSID7023697 Css NA 1.025 mg/L PBTK NA 50% Human Human +DTXSID7023697 Css NA 10.56 mg/L PBTK NA 95% Human Human +DTXSID7023697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023697 Fup 0.0183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023697 Vd NA 0.2537 L/kg 1compartment NA NA Rat Human DTXSID7023697 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023697 TK.Half.Life NA 0.1623 hours 1compartment NA NA Rat Human -DTXSID7023697 Css NA 0.06286 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023697 Css NA 0.5225 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023697 Css NA 0.03453 mg/L PBTK NA 50% Rat Human -DTXSID7023697 Css NA 0.285 mg/L PBTK NA 95% Rat Human -DTXSID7023699 Clint NA 5.826 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023699 Fup NA 0.0518 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023699 Vd NA 0.244 L/kg 1compartment NA NA Human Human +DTXSID7023697 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human +DTXSID7023697 Css NA 0.224 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023697 Css NA 1.814 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023697 Css NA 0.1299 mg/L PBTK NA 50% Rat Human +DTXSID7023697 Css NA 1.03 mg/L PBTK NA 95% Rat Human +DTXSID7023699 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023699 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023699 Vd NA 0.4293 L/kg 1compartment NA NA Human Human DTXSID7023699 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023699 TK.Half.Life NA 3.04 hours 1compartment NA NA Human Human -DTXSID7023699 Css NA 2.12 mg/L 3compartmentss NA 50% Human Human -DTXSID7023699 Css NA 14.49 mg/L 3compartmentss NA 95% Human Human -DTXSID7023699 Css NA 1.269 mg/L PBTK NA 50% Human Human -DTXSID7023699 Css NA 8.518 mg/L PBTK NA 95% Human Human -DTXSID7023699 Clint NA 5.826 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023699 Fup NA 0.0518 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023699 Vd NA 0.2359 L/kg 1compartment NA NA Rat Human +DTXSID7023699 TK.Half.Life NA 1.448 hours 1compartment NA NA Human Human +DTXSID7023699 Css NA 0.1765 mg/L 3compartmentss NA 50% Human Human +DTXSID7023699 Css NA 1.168 mg/L 3compartmentss NA 95% Human Human +DTXSID7023699 Css NA 0.1168 mg/L PBTK NA 50% Human Human +DTXSID7023699 Css NA 0.724 mg/L PBTK NA 95% Human Human +DTXSID7023699 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023699 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023699 Vd NA 0.416 L/kg 1compartment NA NA Rat Human DTXSID7023699 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023699 TK.Half.Life NA 1.826 hours 1compartment NA NA Rat Human -DTXSID7023699 Css NA 1.132 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023699 Css NA 5.989 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023699 Css NA 0.6316 mg/L PBTK NA 50% Rat Human -DTXSID7023699 Css NA 3.278 mg/L PBTK NA 95% Rat Human -DTXSID7023722 Clint NA 150.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023722 Fup NA 0.1971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023722 Vd NA 0.3575 L/kg 1compartment NA NA Human Human +DTXSID7023699 TK.Half.Life NA 0.8183 hours 1compartment NA NA Rat Human +DTXSID7023699 Css NA 0.001716 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023699 Css NA 0.009683 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023699 Css NA 0.00109 mg/L PBTK NA 50% Rat Human +DTXSID7023699 Css NA 0.005721 mg/L PBTK NA 95% Rat Human +DTXSID7023722 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023722 Fup 0.512 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023722 Vd NA 0.6143 L/kg 1compartment NA NA Human Human DTXSID7023722 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023722 TK.Half.Life NA 0.3506 hours 1compartment NA NA Human Human -DTXSID7023722 Css NA 0.01793 mg/L 3compartmentss NA 50% Human Human -DTXSID7023722 Css NA 0.1298 mg/L 3compartmentss NA 95% Human Human -DTXSID7023722 Css NA 0.01164 mg/L PBTK NA 50% Human Human -DTXSID7023722 Css NA 0.08109 mg/L PBTK NA 95% Human Human -DTXSID7023722 Clint NA 150.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023722 Fup NA 0.1971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023722 Vd NA 0.3665 L/kg 1compartment NA NA Rat Human +DTXSID7023722 TK.Half.Life NA 7.77 hours 1compartment NA NA Human Human +DTXSID7023722 Css NA 1.389 mg/L 3compartmentss NA 50% Human Human +DTXSID7023722 Css NA 7.639 mg/L 3compartmentss NA 95% Human Human +DTXSID7023722 Css NA 1.061 mg/L PBTK NA 50% Human Human +DTXSID7023722 Css NA 4.801 mg/L PBTK NA 95% Human Human +DTXSID7023722 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023722 Fup 0.512 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023722 Vd NA 0.6312 L/kg 1compartment NA NA Rat Human DTXSID7023722 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023722 TK.Half.Life NA 0.168 hours 1compartment NA NA Rat Human -DTXSID7023722 Css NA 0.01009 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023722 Css NA 0.05736 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023722 Css NA 0.006176 mg/L PBTK NA 50% Rat Human -DTXSID7023722 Css NA 0.03419 mg/L PBTK NA 95% Rat Human -DTXSID7023724 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023724 Fup NA 0.8487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023724 Vd NA 8.285 L/kg 1compartment NA NA Human Human -DTXSID7023724 Days.Css NA 24 Days PBTK NA NA Human Human -DTXSID7023724 TK.Half.Life NA 133.9 hours 1compartment NA NA Human Human -DTXSID7023724 Css NA 0.6871 mg/L 3compartmentss NA 50% Human Human -DTXSID7023724 Css NA 4.675 mg/L 3compartmentss NA 95% Human Human -DTXSID7023724 Css NA 1.412 mg/L PBTK NA 50% Human Human -DTXSID7023724 Css NA 5.211 mg/L PBTK NA 95% Human Human -DTXSID7023724 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023724 Fup NA 0.8487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023724 Vd NA 8.294 L/kg 1compartment NA NA Rat Human -DTXSID7023724 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID7023724 TK.Half.Life NA 27.3 hours 1compartment NA NA Rat Human -DTXSID7023724 Css NA 0.1722 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023724 Css NA 1.096 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023724 Css NA 0.3658 mg/L PBTK NA 50% Rat Human -DTXSID7023724 Css NA 1.147 mg/L PBTK NA 95% Rat Human -DTXSID7023853 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023853 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023853 Vd NA 0.1951 L/kg 1compartment NA NA Human Human -DTXSID7023853 Days.Css NA 64 Days PBTK NA NA Human Human -DTXSID7023853 TK.Half.Life NA 263 hours 1compartment NA NA Human Human -DTXSID7023853 Css NA 233.8 mg/L 3compartmentss NA 50% Human Human -DTXSID7023853 Css NA 1391 mg/L 3compartmentss NA 95% Human Human -DTXSID7023853 Css NA 136.3 mg/L PBTK NA 50% Human Human -DTXSID7023853 Css NA 796.5 mg/L PBTK NA 95% Human Human -DTXSID7023853 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023853 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023853 Vd NA 0.1893 L/kg 1compartment NA NA Rat Human -DTXSID7023853 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID7023853 TK.Half.Life NA 86.96 hours 1compartment NA NA Rat Human -DTXSID7023853 Css NA 66.58 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023853 Css NA 340.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023853 Css NA 36.31 mg/L PBTK NA 50% Rat Human -DTXSID7023853 Css NA 184.2 mg/L PBTK NA 95% Rat Human -DTXSID7023932 Clint NA 11.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023932 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023932 Vd NA 3.062 L/kg 1compartment NA NA Human Human -DTXSID7023932 Days.Css NA 27 Days PBTK NA NA Human Human -DTXSID7023932 TK.Half.Life NA 147.3 hours 1compartment NA NA Human Human -DTXSID7023932 Css NA 6.054 mg/L 3compartmentss NA 50% Human Human -DTXSID7023932 Css NA 40.52 mg/L 3compartmentss NA 95% Human Human -DTXSID7023932 Css NA 4.176 mg/L PBTK NA 50% Human Human -DTXSID7023932 Css NA 26.45 mg/L PBTK NA 95% Human Human -DTXSID7023932 Clint NA 11.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023932 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023932 Vd NA 2.293 L/kg 1compartment NA NA Rat Human -DTXSID7023932 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID7023932 TK.Half.Life NA 21.06 hours 1compartment NA NA Rat Human -DTXSID7023932 Css NA 3.434 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023932 Css NA 18.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023932 Css NA 2.262 mg/L PBTK NA 50% Rat Human -DTXSID7023932 Css NA 11.54 mg/L PBTK NA 95% Rat Human -DTXSID7023936 Clint 52.51 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7023936 Fup NA 0.1108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023936 Vd NA 2.995 L/kg 1compartment NA NA Human Human -DTXSID7023936 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023936 TK.Half.Life NA 12.63 hours 1compartment NA NA Human Human -DTXSID7023936 Css NA 0.4391 mg/L 3compartmentss NA 50% Human Human -DTXSID7023936 Css NA 2.866 mg/L 3compartmentss NA 95% Human Human -DTXSID7023936 Css NA 0.3072 mg/L PBTK NA 50% Human Human -DTXSID7023936 Css NA 1.921 mg/L PBTK NA 95% Human Human -DTXSID7023936 Clint 52.51 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7023936 Fup NA 0.1108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023936 Vd NA 2.251 L/kg 1compartment NA NA Rat Human -DTXSID7023936 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023936 TK.Half.Life NA 2.391 hours 1compartment NA NA Rat Human -DTXSID7023936 Css NA 0.245 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023936 Css NA 1.263 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023936 Css NA 0.1635 mg/L PBTK NA 50% Rat Human -DTXSID7023936 Css NA 0.8304 mg/L PBTK NA 95% Rat Human -DTXSID7023938 Clint NA 7.383 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023938 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023938 Vd NA 2.117 L/kg 1compartment NA NA Human Human -DTXSID7023938 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID7023938 TK.Half.Life NA 42.21 hours 1compartment NA NA Human Human -DTXSID7023938 Css NA 3.095 mg/L 3compartmentss NA 50% Human Human -DTXSID7023938 Css NA 20.53 mg/L 3compartmentss NA 95% Human Human -DTXSID7023938 Css NA 2.014 mg/L PBTK NA 50% Human Human -DTXSID7023938 Css NA 12.8 mg/L PBTK NA 95% Human Human -DTXSID7023938 Clint NA 7.383 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023938 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023938 Vd NA 1.58 L/kg 1compartment NA NA Rat Human -DTXSID7023938 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7023938 TK.Half.Life NA 12.54 hours 1compartment NA NA Rat Human -DTXSID7023938 Css NA 1.67 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023938 Css NA 8.123 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023938 Css NA 1.027 mg/L PBTK NA 50% Rat Human -DTXSID7023938 Css NA 4.753 mg/L PBTK NA 95% Rat Human -DTXSID7023980 Clint NA 14.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023980 Fup NA 0.0428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7023980 Vd NA 0.2622 L/kg 1compartment NA NA Human Human +DTXSID7023722 TK.Half.Life NA 2.719 hours 1compartment NA NA Rat Human +DTXSID7023722 Css NA 0.08732 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023722 Css NA 0.4223 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023722 Css NA 0.066 mg/L PBTK NA 50% Rat Human +DTXSID7023722 Css NA 0.2575 mg/L PBTK NA 95% Rat Human +DTXSID7023724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023724 Fup 0.0572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023724 Vd NA 2.091 L/kg 1compartment NA NA Human Human +DTXSID7023724 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023724 TK.Half.Life NA 5.169 hours 1compartment NA NA Human Human +DTXSID7023724 Css NA 0.2504 mg/L 3compartmentss NA 50% Human Human +DTXSID7023724 Css NA 2.201 mg/L 3compartmentss NA 95% Human Human +DTXSID7023724 Css NA 0.1897 mg/L PBTK NA 50% Human Human +DTXSID7023724 Css NA 1.496 mg/L PBTK NA 95% Human Human +DTXSID7023724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023724 Fup 0.0572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023724 Vd NA 1.996 L/kg 1compartment NA NA Rat Human +DTXSID7023724 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023724 TK.Half.Life NA 2.88 hours 1compartment NA NA Rat Human +DTXSID7023724 Css NA 0.03201 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023724 Css NA 0.2366 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023724 Css NA 0.02424 mg/L PBTK NA 50% Rat Human +DTXSID7023724 Css NA 0.1606 mg/L PBTK NA 95% Rat Human +DTXSID7023853 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023853 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023853 Vd NA 0.2749 L/kg 1compartment NA NA Human Human +DTXSID7023853 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7023853 TK.Half.Life NA 6.442 hours 1compartment NA NA Human Human +DTXSID7023853 Css NA 3.567 mg/L 3compartmentss NA 50% Human Human +DTXSID7023853 Css NA 31.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7023853 Css NA 2.157 mg/L PBTK NA 50% Human Human +DTXSID7023853 Css NA 18.17 mg/L PBTK NA 95% Human Human +DTXSID7023853 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023853 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023853 Vd NA 0.2667 L/kg 1compartment NA NA Rat Human +DTXSID7023853 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023853 TK.Half.Life NA 3.956 hours 1compartment NA NA Rat Human +DTXSID7023853 Css NA 0.1634 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023853 Css NA 1.617 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023853 Css NA 0.09418 mg/L PBTK NA 50% Rat Human +DTXSID7023853 Css NA 0.9108 mg/L PBTK NA 95% Rat Human +DTXSID70238611 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70238611 Fup 0.9 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human +DTXSID70238611 Vd NA 4.468 L/kg 1compartment NA NA Human Human +DTXSID70238611 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70238611 TK.Half.Life NA 4.933 hours 1compartment NA NA Human Human +DTXSID70238611 Css NA 0.06116 mg/L 3compartmentss NA 50% Human Human +DTXSID70238611 Css NA 0.3656 mg/L 3compartmentss NA 95% Human Human +DTXSID70238611 Css NA 0.05286 mg/L PBTK NA 50% Human Human +DTXSID70238611 Css NA 0.3169 mg/L PBTK NA 95% Human Human +DTXSID70238611 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70238611 Fup 0.9 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human +DTXSID70238611 Vd NA 4.539 L/kg 1compartment NA NA Rat Human +DTXSID70238611 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70238611 TK.Half.Life NA 2.596 hours 1compartment NA NA Rat Human +DTXSID70238611 Css NA 0.002719 mg/L 3compartmentss NA 50% Rat Human +DTXSID70238611 Css NA 0.01638 mg/L 3compartmentss NA 95% Rat Human +DTXSID70238611 Css NA 0.002402 mg/L PBTK NA 50% Rat Human +DTXSID70238611 Css NA 0.01465 mg/L PBTK NA 95% Rat Human +DTXSID70239022 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70239022 Fup 0.805 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70239022 Vd NA 2.003 L/kg 1compartment NA NA Human Human +DTXSID70239022 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID70239022 TK.Half.Life NA 16.11 hours 1compartment NA NA Human Human +DTXSID70239022 Css NA 0.7807 mg/L 3compartmentss NA 50% Human Human +DTXSID70239022 Css NA 5.285 mg/L 3compartmentss NA 95% Human Human +DTXSID70239022 Css NA 0.7916 mg/L PBTK NA 50% Human Human +DTXSID70239022 Css NA 3.653 mg/L PBTK NA 95% Human Human +DTXSID70239022 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70239022 Fup 0.805 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70239022 Vd NA 2.036 L/kg 1compartment NA NA Rat Human +DTXSID70239022 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70239022 TK.Half.Life NA 5.576 hours 1compartment NA NA Rat Human +DTXSID70239022 Css NA 0.04518 mg/L 3compartmentss NA 50% Rat Human +DTXSID70239022 Css NA 0.3037 mg/L 3compartmentss NA 95% Rat Human +DTXSID70239022 Css NA 0.04688 mg/L PBTK NA 50% Rat Human +DTXSID70239022 Css NA 0.2033 mg/L PBTK NA 95% Rat Human +DTXSID70239209 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70239209 Fup 0.41 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70239209 Vd NA 0.8209 L/kg 1compartment NA NA Human Human +DTXSID70239209 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70239209 TK.Half.Life NA 0.9123 hours 1compartment NA NA Human Human +DTXSID70239209 Css NA 0.04837 mg/L 3compartmentss NA 50% Human Human +DTXSID70239209 Css NA 0.3763 mg/L 3compartmentss NA 95% Human Human +DTXSID70239209 Css NA 0.03621 mg/L PBTK NA 50% Human Human +DTXSID70239209 Css NA 0.2614 mg/L PBTK NA 95% Human Human +DTXSID70239209 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70239209 Fup 0.41 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70239209 Vd NA 0.7421 L/kg 1compartment NA NA Rat Human +DTXSID70239209 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70239209 TK.Half.Life NA 0.4196 hours 1compartment NA NA Rat Human +DTXSID70239209 Css NA 0.00603 mg/L 3compartmentss NA 50% Rat Human +DTXSID70239209 Css NA 0.03728 mg/L 3compartmentss NA 95% Rat Human +DTXSID70239209 Css NA 0.004539 mg/L PBTK NA 50% Rat Human +DTXSID70239209 Css NA 0.02476 mg/L PBTK NA 95% Rat Human +DTXSID7023938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023938 Fup 0.0344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023938 Vd NA 2.011 L/kg 1compartment NA NA Human Human +DTXSID7023938 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7023938 TK.Half.Life NA 14.27 hours 1compartment NA NA Human Human +DTXSID7023938 Css NA 0.9983 mg/L 3compartmentss NA 50% Human Human +DTXSID7023938 Css NA 7.211 mg/L 3compartmentss NA 95% Human Human +DTXSID7023938 Css NA 0.6497 mg/L PBTK NA 50% Human Human +DTXSID7023938 Css NA 4.489 mg/L PBTK NA 95% Human Human +DTXSID7023938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023938 Fup 0.0344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023938 Vd NA 1.5 L/kg 1compartment NA NA Rat Human +DTXSID7023938 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7023938 TK.Half.Life NA 4.596 hours 1compartment NA NA Rat Human +DTXSID7023938 Css NA 0.1293 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023938 Css NA 0.7391 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023938 Css NA 0.08199 mg/L PBTK NA 50% Rat Human +DTXSID7023938 Css NA 0.4568 mg/L PBTK NA 95% Rat Human +DTXSID7023980 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023980 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7023980 Vd NA 0.4384 L/kg 1compartment NA NA Human Human DTXSID7023980 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7023980 TK.Half.Life NA 1.82 hours 1compartment NA NA Human Human -DTXSID7023980 Css NA 1.11 mg/L 3compartmentss NA 50% Human Human -DTXSID7023980 Css NA 9.516 mg/L 3compartmentss NA 95% Human Human -DTXSID7023980 Css NA 0.6654 mg/L PBTK NA 50% Human Human -DTXSID7023980 Css NA 5.553 mg/L PBTK NA 95% Human Human -DTXSID7023980 Clint NA 14.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023980 Fup NA 0.0428 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7023980 Vd NA 0.2584 L/kg 1compartment NA NA Rat Human +DTXSID7023980 TK.Half.Life NA 2.051 hours 1compartment NA NA Human Human +DTXSID7023980 Css NA 0.509 mg/L 3compartmentss NA 50% Human Human +DTXSID7023980 Css NA 3.678 mg/L 3compartmentss NA 95% Human Human +DTXSID7023980 Css NA 0.3372 mg/L PBTK NA 50% Human Human +DTXSID7023980 Css NA 2.27 mg/L PBTK NA 95% Human Human +DTXSID7023980 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023980 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7023980 Vd NA 0.4355 L/kg 1compartment NA NA Rat Human DTXSID7023980 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7023980 TK.Half.Life NA 1.147 hours 1compartment NA NA Rat Human -DTXSID7023980 Css NA 0.6261 mg/L 3compartmentss NA 50% Rat Human -DTXSID7023980 Css NA 3.989 mg/L 3compartmentss NA 95% Rat Human -DTXSID7023980 Css NA 0.3539 mg/L PBTK NA 50% Rat Human -DTXSID7023980 Css NA 2.212 mg/L PBTK NA 95% Rat Human +DTXSID7023980 TK.Half.Life NA 1.225 hours 1compartment NA NA Rat Human +DTXSID7023980 Css NA 0.02305 mg/L 3compartmentss NA 50% Rat Human +DTXSID7023980 Css NA 0.1963 mg/L 3compartmentss NA 95% Rat Human +DTXSID7023980 Css NA 0.01494 mg/L PBTK NA 50% Rat Human +DTXSID7023980 Css NA 0.116 mg/L PBTK NA 95% Rat Human DTXSID7024035 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7024035 Fup 0.006623 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7024035 Vd NA 0.2015 L/kg 1compartment NA NA Human Human DTXSID7024035 Days.Css NA 46 Days PBTK NA NA Human Human DTXSID7024035 TK.Half.Life NA 196.9 hours 1compartment NA NA Human Human -DTXSID7024035 Css NA 168.3 mg/L 3compartmentss NA 50% Human Human -DTXSID7024035 Css NA 1022 mg/L 3compartmentss NA 95% Human Human -DTXSID7024035 Css NA 99.15 mg/L PBTK NA 50% Human Human -DTXSID7024035 Css NA 600 mg/L PBTK NA 95% Human Human +DTXSID7024035 Css NA 164 mg/L 3compartmentss NA 50% Human Human +DTXSID7024035 Css NA 997.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7024035 Css NA 96.46 mg/L PBTK NA 50% Human Human +DTXSID7024035 Css NA 583.3 mg/L PBTK NA 95% Human Human DTXSID7024035 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7024035 Fup 0.006623 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7024035 Vd NA 0.1956 L/kg 1compartment NA NA Rat Human DTXSID7024035 Days.Css NA 12 Days PBTK NA NA Rat Human DTXSID7024035 TK.Half.Life NA 65.15 hours 1compartment NA NA Rat Human -DTXSID7024035 Css NA 48.25 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024035 Css NA 259.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024035 Css NA 26.38 mg/L PBTK NA 50% Rat Human -DTXSID7024035 Css NA 140.5 mg/L PBTK NA 95% Rat Human +DTXSID7024035 Css NA 10.76 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024035 Css NA 56.02 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024035 Css NA 6.091 mg/L PBTK NA 50% Rat Human +DTXSID7024035 Css NA 31.41 mg/L PBTK NA 95% Rat Human DTXSID7024081 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7024081 Fup 0.867 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7024081 Vd NA 0.8909 L/kg 1compartment NA NA Human Human DTXSID7024081 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7024081 TK.Half.Life NA 6.652 hours 1compartment NA NA Human Human -DTXSID7024081 Css NA 0.7413 mg/L 3compartmentss NA 50% Human Human -DTXSID7024081 Css NA 2.251 mg/L 3compartmentss NA 95% Human Human -DTXSID7024081 Css NA 0.6966 mg/L PBTK NA 50% Human Human -DTXSID7024081 Css NA 1.787 mg/L PBTK NA 95% Human Human +DTXSID7024081 Css NA 0.7279 mg/L 3compartmentss NA 50% Human Human +DTXSID7024081 Css NA 2.246 mg/L 3compartmentss NA 95% Human Human +DTXSID7024081 Css NA 0.6846 mg/L PBTK NA 50% Human Human +DTXSID7024081 Css NA 1.762 mg/L PBTK NA 95% Human Human DTXSID7024081 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7024081 Fup 0.867 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7024081 Vd NA 0.893 L/kg 1compartment NA NA Rat Human DTXSID7024081 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7024081 TK.Half.Life NA 2.271 hours 1compartment NA NA Rat Human -DTXSID7024081 Css NA 0.1933 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024081 Css NA 0.495 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024081 Css NA 0.1791 mg/L PBTK NA 50% Rat Human -DTXSID7024081 Css NA 0.362 mg/L PBTK NA 95% Rat Human +DTXSID7024081 Css NA 0.04321 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024081 Css NA 0.1117 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024081 Css NA 0.04157 mg/L PBTK NA 50% Rat Human +DTXSID7024081 Css NA 0.08456 mg/L PBTK NA 95% Rat Human DTXSID7024085 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7024085 Fup NA 0.5716 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7024085 Vd NA 0.6019 L/kg 1compartment NA NA Human Human DTXSID7024085 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7024085 TK.Half.Life NA 6.816 hours 1compartment NA NA Human Human -DTXSID7024085 Css NA 1.31 mg/L 3compartmentss NA 50% Human Human -DTXSID7024085 Css NA 9.06 mg/L 3compartmentss NA 95% Human Human -DTXSID7024085 Css NA 1.027 mg/L PBTK NA 50% Human Human -DTXSID7024085 Css NA 5.685 mg/L PBTK NA 95% Human Human +DTXSID7024085 Css NA 1.105 mg/L 3compartmentss NA 50% Human Human +DTXSID7024085 Css NA 7.623 mg/L 3compartmentss NA 95% Human Human +DTXSID7024085 Css NA 0.8661 mg/L PBTK NA 50% Human Human +DTXSID7024085 Css NA 4.805 mg/L PBTK NA 95% Human Human DTXSID7024085 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7024085 Fup NA 0.5716 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7024085 Vd NA 0.6241 L/kg 1compartment NA NA Rat Human DTXSID7024085 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7024085 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human -DTXSID7024085 Css NA 0.3474 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024085 Css NA 2.246 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024085 Css NA 0.2597 mg/L PBTK NA 50% Rat Human -DTXSID7024085 Css NA 1.306 mg/L PBTK NA 95% Rat Human -DTXSID7024087 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024087 Fup NA 0.9137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024087 Vd NA 0.8318 L/kg 1compartment NA NA Human Human +DTXSID7024085 Css NA 0.02151 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024085 Css NA 0.1743 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024085 Css NA 0.01613 mg/L PBTK NA 50% Rat Human +DTXSID7024085 Css NA 0.1088 mg/L PBTK NA 95% Rat Human +DTXSID7024087 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024087 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024087 Vd NA 0.5631 L/kg 1compartment NA NA Human Human DTXSID7024087 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024087 TK.Half.Life NA 5.909 hours 1compartment NA NA Human Human -DTXSID7024087 Css NA 0.8594 mg/L 3compartmentss NA 50% Human Human -DTXSID7024087 Css NA 3.329 mg/L 3compartmentss NA 95% Human Human -DTXSID7024087 Css NA 0.7309 mg/L PBTK NA 50% Human Human -DTXSID7024087 Css NA 2.329 mg/L PBTK NA 95% Human Human -DTXSID7024087 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024087 Fup NA 0.9137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024087 Vd NA 0.8537 L/kg 1compartment NA NA Rat Human +DTXSID7024087 TK.Half.Life NA 7.747 hours 1compartment NA NA Human Human +DTXSID7024087 Css NA 1.317 mg/L 3compartmentss NA 50% Human Human +DTXSID7024087 Css NA 6.086 mg/L 3compartmentss NA 95% Human Human +DTXSID7024087 Css NA 0.9928 mg/L PBTK NA 50% Human Human +DTXSID7024087 Css NA 3.878 mg/L PBTK NA 95% Human Human +DTXSID7024087 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024087 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024087 Vd NA 0.5756 L/kg 1compartment NA NA Rat Human DTXSID7024087 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024087 TK.Half.Life NA 2.062 hours 1compartment NA NA Rat Human -DTXSID7024087 Css NA 0.2207 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024087 Css NA 0.813 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024087 Css NA 0.1837 mg/L PBTK NA 50% Rat Human -DTXSID7024087 Css NA 0.5226 mg/L PBTK NA 95% Rat Human -DTXSID7024110 Clint NA 144.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024110 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024110 Vd NA 3.21 L/kg 1compartment NA NA Human Human -DTXSID7024110 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7024110 TK.Half.Life NA 17.18 hours 1compartment NA NA Human Human -DTXSID7024110 Css NA 0.5354 mg/L 3compartmentss NA 50% Human Human -DTXSID7024110 Css NA 3.144 mg/L 3compartmentss NA 95% Human Human -DTXSID7024110 Css NA 0.3756 mg/L PBTK NA 50% Human Human -DTXSID7024110 Css NA 2.182 mg/L PBTK NA 95% Human Human -DTXSID7024110 Clint NA 144.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024110 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024110 Vd NA 2.407 L/kg 1compartment NA NA Rat Human -DTXSID7024110 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024110 TK.Half.Life NA 2.889 hours 1compartment NA NA Rat Human -DTXSID7024110 Css NA 0.3082 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024110 Css NA 1.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024110 Css NA 0.2063 mg/L PBTK NA 50% Rat Human -DTXSID7024110 Css NA 0.8551 mg/L PBTK NA 95% Rat Human +DTXSID7024087 TK.Half.Life NA 2.696 hours 1compartment NA NA Rat Human +DTXSID7024087 Css NA 0.0244 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024087 Css NA 0.1628 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024087 Css NA 0.01761 mg/L PBTK NA 50% Rat Human +DTXSID7024087 Css NA 0.103 mg/L PBTK NA 95% Rat Human +DTXSID7024110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024110 Fup 0.00893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024110 Vd NA 3.043 L/kg 1compartment NA NA Human Human +DTXSID7024110 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID7024110 TK.Half.Life NA 81.82 hours 1compartment NA NA Human Human +DTXSID7024110 Css NA 3.303 mg/L 3compartmentss NA 50% Human Human +DTXSID7024110 Css NA 20.78 mg/L 3compartmentss NA 95% Human Human +DTXSID7024110 Css NA 2.272 mg/L PBTK NA 50% Human Human +DTXSID7024110 Css NA 13.9 mg/L PBTK NA 95% Human Human +DTXSID7024110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024110 Fup 0.00893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024110 Vd NA 2.278 L/kg 1compartment NA NA Rat Human +DTXSID7024110 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID7024110 TK.Half.Life NA 12.2 hours 1compartment NA NA Rat Human +DTXSID7024110 Css NA 0.431 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024110 Css NA 2.385 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024110 Css NA 0.2918 mg/L PBTK NA 50% Rat Human +DTXSID7024110 Css NA 1.573 mg/L PBTK NA 95% Rat Human DTXSID7024112 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7024112 Fup 0.017 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7024112 Vd NA 0.2219 L/kg 1compartment NA NA Human Human DTXSID7024112 Days.Css NA 17 Days PBTK NA NA Human Human DTXSID7024112 TK.Half.Life NA 84.6 hours 1compartment NA NA Human Human -DTXSID7024112 Css NA 44.54 mg/L 3compartmentss NA 50% Human Human -DTXSID7024112 Css NA 204.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7024112 Css NA 26.47 mg/L PBTK NA 50% Human Human -DTXSID7024112 Css NA 118 mg/L PBTK NA 95% Human Human +DTXSID7024112 Css NA 36.2 mg/L 3compartmentss NA 50% Human Human +DTXSID7024112 Css NA 175.6 mg/L 3compartmentss NA 95% Human Human +DTXSID7024112 Css NA 21.44 mg/L PBTK NA 50% Human Human +DTXSID7024112 Css NA 101 mg/L PBTK NA 95% Human Human DTXSID7024112 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7024112 Fup 0.017 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7024112 Vd NA 0.2061 L/kg 1compartment NA NA Rat Human DTXSID7024112 Days.Css NA 4 Days PBTK NA NA Rat Human DTXSID7024112 TK.Half.Life NA 26.75 hours 1compartment NA NA Rat Human -DTXSID7024112 Css NA 12.66 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024112 Css NA 48.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024112 Css NA 7 mg/L PBTK NA 50% Rat Human -DTXSID7024112 Css NA 26.09 mg/L PBTK NA 95% Rat Human +DTXSID7024112 Css NA 0.519 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024112 Css NA 3.87 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024112 Css NA 0.2896 mg/L PBTK NA 50% Rat Human +DTXSID7024112 Css NA 2.155 mg/L PBTK NA 95% Rat Human DTXSID7024160 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7024160 Fup NA 0.0086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024160 Vd NA 1.095 L/kg 1compartment NA NA Human Human -DTXSID7024160 Days.Css NA 267 Days PBTK NA NA Human Human -DTXSID7024160 TK.Half.Life NA 1009 hours 1compartment NA NA Human Human -DTXSID7024160 Css NA 150.1 mg/L 3compartmentss NA 50% Human Human -DTXSID7024160 Css NA 831.4 mg/L 3compartmentss NA 95% Human Human -DTXSID7024160 Css NA 91.54 mg/L PBTK NA 50% Human Human -DTXSID7024160 Css NA 484.7 mg/L PBTK NA 95% Human Human +DTXSID7024160 Fup 0.00857 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024160 Vd NA 1.094 L/kg 1compartment NA NA Human Human +DTXSID7024160 Days.Css NA 263 Days PBTK NA NA Human Human +DTXSID7024160 TK.Half.Life NA 1011 hours 1compartment NA NA Human Human +DTXSID7024160 Css NA 147.5 mg/L 3compartmentss NA 50% Human Human +DTXSID7024160 Css NA 812.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7024160 Css NA 90.22 mg/L PBTK NA 50% Human Human +DTXSID7024160 Css NA 474.1 mg/L PBTK NA 95% Human Human DTXSID7024160 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7024160 Fup NA 0.0086 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024160 Vd NA 0.8073 L/kg 1compartment NA NA Rat Human +DTXSID7024160 Fup 0.00857 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024160 Vd NA 0.8057 L/kg 1compartment NA NA Rat Human DTXSID7024160 Days.Css NA 62 Days PBTK NA NA Rat Human -DTXSID7024160 TK.Half.Life NA 218.1 hours 1compartment NA NA Rat Human -DTXSID7024160 Css NA 42.26 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024160 Css NA 201.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024160 Css NA 24.03 mg/L PBTK NA 50% Rat Human -DTXSID7024160 Css NA 110 mg/L PBTK NA 95% Rat Human +DTXSID7024160 TK.Half.Life NA 218.3 hours 1compartment NA NA Rat Human +DTXSID7024160 Css NA 9.459 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024160 Css NA 46.38 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024160 Css NA 5.57 mg/L PBTK NA 50% Rat Human +DTXSID7024160 Css NA 26.24 mg/L PBTK NA 95% Rat Human DTXSID7024164 Clint 1.65 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7024164 Fup 0.00905 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7024164 Vd NA 0.1783 L/kg 1compartment NA NA Human Human DTXSID7024164 Days.Css NA 5 Days PBTK NA NA Human Human DTXSID7024164 TK.Half.Life NA 34.26 hours 1compartment NA NA Human Human -DTXSID7024164 Css NA 21.61 mg/L 3compartmentss NA 50% Human Human -DTXSID7024164 Css NA 78.35 mg/L 3compartmentss NA 95% Human Human -DTXSID7024164 Css NA 12.69 mg/L PBTK NA 50% Human Human -DTXSID7024164 Css NA 45.75 mg/L PBTK NA 95% Human Human +DTXSID7024164 Css NA 21.17 mg/L 3compartmentss NA 50% Human Human +DTXSID7024164 Css NA 78.16 mg/L 3compartmentss NA 95% Human Human +DTXSID7024164 Css NA 12.45 mg/L PBTK NA 50% Human Human +DTXSID7024164 Css NA 45.26 mg/L PBTK NA 95% Human Human DTXSID7024164 Clint 1.65 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7024164 Fup 0.00905 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7024164 Vd NA 0.1754 L/kg 1compartment NA NA Rat Human DTXSID7024164 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID7024164 TK.Half.Life NA 18.41 hours 1compartment NA NA Rat Human -DTXSID7024164 Css NA 9.824 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024164 Css NA 24.96 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024164 Css NA 5.378 mg/L PBTK NA 50% Rat Human -DTXSID7024164 Css NA 13.55 mg/L PBTK NA 95% Rat Human +DTXSID7024164 Css NA 2.219 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024164 Css NA 5.714 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024164 Css NA 1.257 mg/L PBTK NA 50% Rat Human +DTXSID7024164 Css NA 3.219 mg/L PBTK NA 95% Rat Human DTXSID7024166 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7024166 Fup NA 0.8203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024166 Vd NA 0.7643 L/kg 1compartment NA NA Human Human +DTXSID7024166 Vd NA 0.6164 L/kg 1compartment NA NA Human Human DTXSID7024166 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024166 TK.Half.Life NA 6.043 hours 1compartment NA NA Human Human -DTXSID7024166 Css NA 0.9672 mg/L 3compartmentss NA 50% Human Human -DTXSID7024166 Css NA 5.827 mg/L 3compartmentss NA 95% Human Human -DTXSID7024166 Css NA 0.8066 mg/L PBTK NA 50% Human Human -DTXSID7024166 Css NA 3.772 mg/L PBTK NA 95% Human Human +DTXSID7024166 TK.Half.Life NA 4.861 hours 1compartment NA NA Human Human +DTXSID7024166 Css NA 0.8624 mg/L 3compartmentss NA 50% Human Human +DTXSID7024166 Css NA 5.113 mg/L 3compartmentss NA 95% Human Human +DTXSID7024166 Css NA 0.6878 mg/L PBTK NA 50% Human Human +DTXSID7024166 Css NA 3.297 mg/L PBTK NA 95% Human Human DTXSID7024166 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7024166 Fup NA 0.8203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024166 Vd NA 0.7871 L/kg 1compartment NA NA Rat Human +DTXSID7024166 Vd NA 0.6615 L/kg 1compartment NA NA Rat Human DTXSID7024166 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024166 TK.Half.Life NA 2.116 hours 1compartment NA NA Rat Human -DTXSID7024166 Css NA 0.2482 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024166 Css NA 1.492 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024166 Css NA 0.1999 mg/L PBTK NA 50% Rat Human -DTXSID7024166 Css NA 0.8944 mg/L PBTK NA 95% Rat Human +DTXSID7024166 TK.Half.Life NA 1.778 hours 1compartment NA NA Rat Human +DTXSID7024166 Css NA 0.01626 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024166 Css NA 0.1227 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024166 Css NA 0.01238 mg/L PBTK NA 50% Rat Human +DTXSID7024166 Css NA 0.07814 mg/L PBTK NA 95% Rat Human +DTXSID70241766 Clint 0.2487 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70241766 Fup 0.0938 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70241766 Vd NA 1.976 L/kg 1compartment NA NA Human Human +DTXSID70241766 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID70241766 TK.Half.Life NA 152.8 hours 1compartment NA NA Human Human +DTXSID70241766 Css NA 9.972 mg/L 3compartmentss NA 50% Human Human +DTXSID70241766 Css NA 39.79 mg/L 3compartmentss NA 95% Human Human +DTXSID70241766 Css NA 6.839 mg/L PBTK NA 50% Human Human +DTXSID70241766 Css NA 24.39 mg/L PBTK NA 95% Human Human +DTXSID70241766 Clint 0.2487 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70241766 Fup 0.0938 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70241766 Vd NA 1.529 L/kg 1compartment NA NA Rat Human +DTXSID70241766 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID70241766 TK.Half.Life NA 33.49 hours 1compartment NA NA Rat Human +DTXSID70241766 Css NA 0.7946 mg/L 3compartmentss NA 50% Rat Human +DTXSID70241766 Css NA 2.599 mg/L 3compartmentss NA 95% Rat Human +DTXSID70241766 Css NA 0.5326 mg/L PBTK NA 50% Rat Human +DTXSID70241766 Css NA 1.558 mg/L PBTK NA 95% Rat Human DTXSID7024241 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7024241 Fup 0.1218 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7024241 Vd NA 3.104 L/kg 1compartment NA NA Human Human -DTXSID7024241 Days.Css NA 2195 Days PBTK NA NA Human Human +DTXSID7024241 Days.Css NA 2198 Days PBTK NA NA Human Human DTXSID7024241 TK.Half.Life NA 8040 hours 1compartment NA NA Human Human -DTXSID7024241 Css NA 292 mg/L 3compartmentss NA 50% Human Human -DTXSID7024241 Css NA 833.2 mg/L 3compartmentss NA 95% Human Human -DTXSID7024241 Css NA 204.3 mg/L PBTK NA 50% Human Human -DTXSID7024241 Css NA 546 mg/L PBTK NA 95% Human Human +DTXSID7024241 Css NA 287.6 mg/L 3compartmentss NA 50% Human Human +DTXSID7024241 Css NA 777.3 mg/L 3compartmentss NA 95% Human Human +DTXSID7024241 Css NA 201.2 mg/L PBTK NA 50% Human Human +DTXSID7024241 Css NA 507.7 mg/L PBTK NA 95% Human Human DTXSID7024241 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7024241 Fup 0.1218 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7024241 Vd NA 2.328 L/kg 1compartment NA NA Rat Human -DTXSID7024241 Days.Css NA 560 Days PBTK NA NA Rat Human +DTXSID7024241 Days.Css NA 556 Days PBTK NA NA Rat Human DTXSID7024241 TK.Half.Life NA 521.6 hours 1compartment NA NA Rat Human -DTXSID7024241 Css NA 80.04 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024241 Css NA 176.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024241 Css NA 53.59 mg/L PBTK NA 50% Rat Human -DTXSID7024241 Css NA 107 mg/L PBTK NA 95% Rat Human +DTXSID7024241 Css NA 18 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024241 Css NA 39.24 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024241 Css NA 12.48 mg/L PBTK NA 50% Rat Human +DTXSID7024241 Css NA 24.62 mg/L PBTK NA 95% Rat Human DTXSID7024245 Clint 7.214 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7024245 Fup NA 0.0504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024245 Vd NA 3.107 L/kg 1compartment NA NA Human Human -DTXSID7024245 Days.Css NA 41 Days PBTK NA NA Human Human -DTXSID7024245 TK.Half.Life NA 203.4 hours 1compartment NA NA Human Human -DTXSID7024245 Css NA 8.051 mg/L 3compartmentss NA 50% Human Human -DTXSID7024245 Css NA 49.14 mg/L 3compartmentss NA 95% Human Human -DTXSID7024245 Css NA 5.633 mg/L PBTK NA 50% Human Human -DTXSID7024245 Css NA 33.3 mg/L PBTK NA 95% Human Human +DTXSID7024245 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024245 Vd NA 2.983 L/kg 1compartment NA NA Human Human +DTXSID7024245 Days.Css NA 42 Days PBTK NA NA Human Human +DTXSID7024245 TK.Half.Life NA 207.3 hours 1compartment NA NA Human Human +DTXSID7024245 Css NA 8.994 mg/L 3compartmentss NA 50% Human Human +DTXSID7024245 Css NA 56.68 mg/L 3compartmentss NA 95% Human Human +DTXSID7024245 Css NA 6.142 mg/L PBTK NA 50% Human Human +DTXSID7024245 Css NA 38.37 mg/L PBTK NA 95% Human Human DTXSID7024245 Clint 7.214 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7024245 Fup NA 0.0504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024245 Vd NA 2.328 L/kg 1compartment NA NA Rat Human -DTXSID7024245 Days.Css NA 22 Days PBTK NA NA Rat Human -DTXSID7024245 TK.Half.Life NA 27.11 hours 1compartment NA NA Rat Human -DTXSID7024245 Css NA 4.472 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024245 Css NA 23 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024245 Css NA 2.981 mg/L PBTK NA 50% Rat Human -DTXSID7024245 Css NA 14.7 mg/L PBTK NA 95% Rat Human -DTXSID7024291 Clint NA 92.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024291 Fup NA 0.0221 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024291 Vd NA 2.758 L/kg 1compartment NA NA Human Human -DTXSID7024291 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024291 TK.Half.Life NA 11.03 hours 1compartment NA NA Human Human -DTXSID7024291 Css NA 0.4537 mg/L 3compartmentss NA 50% Human Human -DTXSID7024291 Css NA 3.207 mg/L 3compartmentss NA 95% Human Human -DTXSID7024291 Css NA 0.3073 mg/L PBTK NA 50% Human Human -DTXSID7024291 Css NA 2.082 mg/L PBTK NA 95% Human Human -DTXSID7024291 Clint NA 92.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024291 Fup NA 0.0221 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024291 Vd NA 2.062 L/kg 1compartment NA NA Rat Human -DTXSID7024291 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024291 TK.Half.Life NA 2.478 hours 1compartment NA NA Rat Human -DTXSID7024291 Css NA 0.255 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024291 Css NA 1.513 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024291 Css NA 0.1636 mg/L PBTK NA 50% Rat Human -DTXSID7024291 Css NA 0.9415 mg/L PBTK NA 95% Rat Human +DTXSID7024245 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024245 Vd NA 2.232 L/kg 1compartment NA NA Rat Human +DTXSID7024245 Days.Css NA 23 Days PBTK NA NA Rat Human +DTXSID7024245 TK.Half.Life NA 32.34 hours 1compartment NA NA Rat Human +DTXSID7024245 Css NA 1.159 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024245 Css NA 6.479 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024245 Css NA 0.7846 mg/L PBTK NA 50% Rat Human +DTXSID7024245 Css NA 4.243 mg/L PBTK NA 95% Rat Human +DTXSID7024291 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024291 Fup 0.0235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024291 Vd NA 2.778 L/kg 1compartment NA NA Human Human +DTXSID7024291 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID7024291 TK.Half.Life NA 39.05 hours 1compartment NA NA Human Human +DTXSID7024291 Css NA 1.832 mg/L 3compartmentss NA 50% Human Human +DTXSID7024291 Css NA 13.24 mg/L 3compartmentss NA 95% Human Human +DTXSID7024291 Css NA 1.233 mg/L PBTK NA 50% Human Human +DTXSID7024291 Css NA 8.552 mg/L PBTK NA 95% Human Human +DTXSID7024291 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024291 Fup 0.0235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024291 Vd NA 2.078 L/kg 1compartment NA NA Rat Human +DTXSID7024291 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7024291 TK.Half.Life NA 7.845 hours 1compartment NA NA Rat Human +DTXSID7024291 Css NA 0.2366 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024291 Css NA 1.396 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024291 Css NA 0.1574 mg/L PBTK NA 50% Rat Human +DTXSID7024291 Css NA 0.895 mg/L PBTK NA 95% Rat Human DTXSID7024299 Clint 110.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7024299 Fup NA 0.0308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024299 Vd NA 0.9897 L/kg 1compartment NA NA Human Human +DTXSID7024299 Fup 0.0276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024299 Vd NA 1.486 L/kg 1compartment NA NA Human Human DTXSID7024299 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024299 TK.Half.Life NA 1.978 hours 1compartment NA NA Human Human -DTXSID7024299 Css NA 0.2007 mg/L 3compartmentss NA 50% Human Human -DTXSID7024299 Css NA 1.914 mg/L 3compartmentss NA 95% Human Human -DTXSID7024299 Css NA 0.1238 mg/L PBTK NA 50% Human Human -DTXSID7024299 Css NA 1.131 mg/L PBTK NA 95% Human Human +DTXSID7024299 TK.Half.Life NA 3.224 hours 1compartment NA NA Human Human +DTXSID7024299 Css NA 0.2174 mg/L 3compartmentss NA 50% Human Human +DTXSID7024299 Css NA 2.096 mg/L 3compartmentss NA 95% Human Human +DTXSID7024299 Css NA 0.1357 mg/L PBTK NA 50% Human Human +DTXSID7024299 Css NA 1.255 mg/L PBTK NA 95% Human Human DTXSID7024299 Clint 110.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7024299 Fup NA 0.0308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024299 Vd NA 0.7448 L/kg 1compartment NA NA Rat Human +DTXSID7024299 Fup 0.0276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024299 Vd NA 1.106 L/kg 1compartment NA NA Rat Human DTXSID7024299 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024299 TK.Half.Life NA 0.7986 hours 1compartment NA NA Rat Human -DTXSID7024299 Css NA 0.1158 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024299 Css NA 0.9138 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024299 Css NA 0.06645 mg/L PBTK NA 50% Rat Human -DTXSID7024299 Css NA 0.5063 mg/L PBTK NA 95% Rat Human +DTXSID7024299 TK.Half.Life NA 1.193 hours 1compartment NA NA Rat Human +DTXSID7024299 Css NA 0.02882 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024299 Css NA 0.2233 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024299 Css NA 0.01768 mg/L PBTK NA 50% Rat Human +DTXSID7024299 Css NA 0.13 mg/L PBTK NA 95% Rat Human DTXSID7024328 Clint 101 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7024328 Fup 0.0206 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7024328 Vd NA 2.258 L/kg 1compartment NA NA Human Human DTXSID7024328 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7024328 TK.Half.Life NA 6.87 hours 1compartment NA NA Human Human -DTXSID7024328 Css NA 0.2786 mg/L 3compartmentss NA 50% Human Human -DTXSID7024328 Css NA 1.868 mg/L 3compartmentss NA 95% Human Human -DTXSID7024328 Css NA 0.1856 mg/L PBTK NA 50% Human Human -DTXSID7024328 Css NA 1.202 mg/L PBTK NA 95% Human Human +DTXSID7024328 Css NA 0.2712 mg/L 3compartmentss NA 50% Human Human +DTXSID7024328 Css NA 1.775 mg/L 3compartmentss NA 95% Human Human +DTXSID7024328 Css NA 0.1798 mg/L PBTK NA 50% Human Human +DTXSID7024328 Css NA 1.14 mg/L PBTK NA 95% Human Human DTXSID7024328 Clint 101 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7024328 Fup 0.0206 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7024328 Vd NA 1.682 L/kg 1compartment NA NA Rat Human DTXSID7024328 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7024328 TK.Half.Life NA 2.035 hours 1compartment NA NA Rat Human -DTXSID7024328 Css NA 0.1573 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024328 Css NA 0.866 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024328 Css NA 0.09916 mg/L PBTK NA 50% Rat Human -DTXSID7024328 Css NA 0.539 mg/L PBTK NA 95% Rat Human +DTXSID7024328 Css NA 0.03503 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024328 Css NA 0.2055 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024328 Css NA 0.02292 mg/L PBTK NA 50% Rat Human +DTXSID7024328 Css NA 0.1317 mg/L PBTK NA 95% Rat Human DTXSID7024376 Clint 25.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7024376 Fup 0.01906 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7024376 Vd NA 2 L/kg 1compartment NA NA Human Human DTXSID7024376 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID7024376 TK.Half.Life NA 18.47 hours 1compartment NA NA Human Human -DTXSID7024376 Css NA 1.405 mg/L 3compartmentss NA 50% Human Human -DTXSID7024376 Css NA 11.83 mg/L 3compartmentss NA 95% Human Human -DTXSID7024376 Css NA 0.8981 mg/L PBTK NA 50% Human Human -DTXSID7024376 Css NA 7.2 mg/L PBTK NA 95% Human Human +DTXSID7024376 Css NA 1.354 mg/L 3compartmentss NA 50% Human Human +DTXSID7024376 Css NA 11.12 mg/L 3compartmentss NA 95% Human Human +DTXSID7024376 Css NA 0.8692 mg/L PBTK NA 50% Human Human +DTXSID7024376 Css NA 6.87 mg/L PBTK NA 95% Human Human DTXSID7024376 Clint 25.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7024376 Fup 0.01906 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7024376 Vd NA 1.487 L/kg 1compartment NA NA Rat Human DTXSID7024376 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7024376 TK.Half.Life NA 5.95 hours 1compartment NA NA Rat Human -DTXSID7024376 Css NA 0.7814 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024376 Css NA 5.124 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024376 Css NA 0.4728 mg/L PBTK NA 50% Rat Human -DTXSID7024376 Css NA 2.953 mg/L PBTK NA 95% Rat Human -DTXSID7024409 Clint NA 3.373 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024409 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024409 Vd NA 1.277 L/kg 1compartment NA NA Human Human +DTXSID7024376 Css NA 0.1747 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024376 Css NA 1.218 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024376 Css NA 0.1096 mg/L PBTK NA 50% Rat Human +DTXSID7024376 Css NA 0.7284 mg/L PBTK NA 95% Rat Human +DTXSID7024409 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024409 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024409 Vd NA 0.7934 L/kg 1compartment NA NA Human Human DTXSID7024409 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024409 TK.Half.Life NA 1.776 hours 1compartment NA NA Human Human -DTXSID7024409 Css NA 0.1196 mg/L 3compartmentss NA 50% Human Human -DTXSID7024409 Css NA 1.118 mg/L 3compartmentss NA 95% Human Human -DTXSID7024409 Css NA 0.1099 mg/L PBTK NA 50% Human Human -DTXSID7024409 Css NA 0.7989 mg/L PBTK NA 95% Human Human -DTXSID7024409 Clint NA 3.373 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024409 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024409 Vd NA 1.216 L/kg 1compartment NA NA Rat Human +DTXSID7024409 TK.Half.Life NA 0.8274 hours 1compartment NA NA Human Human +DTXSID7024409 Css NA 0.04219 mg/L 3compartmentss NA 50% Human Human +DTXSID7024409 Css NA 0.3759 mg/L 3compartmentss NA 95% Human Human +DTXSID7024409 Css NA 0.0326 mg/L PBTK NA 50% Human Human +DTXSID7024409 Css NA 0.2583 mg/L PBTK NA 95% Human Human +DTXSID7024409 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024409 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024409 Vd NA 0.7508 L/kg 1compartment NA NA Rat Human DTXSID7024409 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024409 TK.Half.Life NA 0.8696 hours 1compartment NA NA Rat Human -DTXSID7024409 Css NA 0.05292 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024409 Css NA 0.3658 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024409 Css NA 0.04884 mg/L PBTK NA 50% Rat Human -DTXSID7024409 Css NA 0.2405 mg/L PBTK NA 95% Rat Human -DTXSID7024455 Clint NA 1.166 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024455 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024455 Vd NA 0.9665 L/kg 1compartment NA NA Human Human +DTXSID7024409 TK.Half.Life NA 0.3979 hours 1compartment NA NA Rat Human +DTXSID7024409 Css NA 0.005232 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024409 Css NA 0.03393 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024409 Css NA 0.004069 mg/L PBTK NA 50% Rat Human +DTXSID7024409 Css NA 0.02323 mg/L PBTK NA 95% Rat Human +DTXSID7024455 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024455 Fup 0.594 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024455 Vd NA 0.7045 L/kg 1compartment NA NA Human Human DTXSID7024455 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024455 TK.Half.Life NA 2.379 hours 1compartment NA NA Human Human -DTXSID7024455 Css NA 0.277 mg/L 3compartmentss NA 50% Human Human -DTXSID7024455 Css NA 1.93 mg/L 3compartmentss NA 95% Human Human -DTXSID7024455 Css NA 0.2429 mg/L PBTK NA 50% Human Human -DTXSID7024455 Css NA 1.331 mg/L PBTK NA 95% Human Human -DTXSID7024455 Clint NA 1.166 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024455 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024455 Vd NA 0.9757 L/kg 1compartment NA NA Rat Human +DTXSID7024455 TK.Half.Life NA 7.713 hours 1compartment NA NA Human Human +DTXSID7024455 Css NA 1.211 mg/L 3compartmentss NA 50% Human Human +DTXSID7024455 Css NA 8.29 mg/L 3compartmentss NA 95% Human Human +DTXSID7024455 Css NA 0.9672 mg/L PBTK NA 50% Human Human +DTXSID7024455 Css NA 5.328 mg/L PBTK NA 95% Human Human +DTXSID7024455 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024455 Fup 0.594 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024455 Vd NA 0.7091 L/kg 1compartment NA NA Rat Human DTXSID7024455 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024455 TK.Half.Life NA 1.167 hours 1compartment NA NA Rat Human -DTXSID7024455 Css NA 0.1044 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024455 Css NA 0.6906 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024455 Css NA 0.09094 mg/L PBTK NA 50% Rat Human -DTXSID7024455 Css NA 0.4214 mg/L PBTK NA 95% Rat Human -DTXSID7024457 Clint NA 6.536 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024457 Fup NA 0.284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024457 Vd NA 3.356 L/kg 1compartment NA NA Human Human +DTXSID7024455 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human +DTXSID7024455 Css NA 0.07318 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024455 Css NA 0.4597 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024455 Css NA 0.05823 mg/L PBTK NA 50% Rat Human +DTXSID7024455 Css NA 0.2797 mg/L PBTK NA 95% Rat Human +DTXSID7024457 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024457 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024457 Vd NA 1.899 L/kg 1compartment NA NA Human Human DTXSID7024457 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024457 TK.Half.Life NA 6.918 hours 1compartment NA NA Human Human -DTXSID7024457 Css NA 0.1279 mg/L 3compartmentss NA 50% Human Human -DTXSID7024457 Css NA 0.9426 mg/L 3compartmentss NA 95% Human Human -DTXSID7024457 Css NA 0.1482 mg/L PBTK NA 50% Human Human -DTXSID7024457 Css NA 0.857 mg/L PBTK NA 95% Human Human -DTXSID7024457 Clint NA 6.536 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024457 Fup NA 0.284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024457 Vd NA 3.398 L/kg 1compartment NA NA Rat Human +DTXSID7024457 TK.Half.Life NA 3.623 hours 1compartment NA NA Human Human +DTXSID7024457 Css NA 0.1594 mg/L 3compartmentss NA 50% Human Human +DTXSID7024457 Css NA 1.396 mg/L 3compartmentss NA 95% Human Human +DTXSID7024457 Css NA 0.1256 mg/L PBTK NA 50% Human Human +DTXSID7024457 Css NA 0.9759 mg/L PBTK NA 95% Human Human +DTXSID7024457 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024457 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024457 Vd NA 1.879 L/kg 1compartment NA NA Rat Human DTXSID7024457 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024457 TK.Half.Life NA 4.153 hours 1compartment NA NA Rat Human -DTXSID7024457 Css NA 0.06279 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024457 Css NA 0.369 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024457 Css NA 0.07291 mg/L PBTK NA 50% Rat Human -DTXSID7024457 Css NA 0.3094 mg/L PBTK NA 95% Rat Human -DTXSID7024532 Clint NA 66.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024532 Fup NA 0.7292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024532 Vd NA 1.12 L/kg 1compartment NA NA Human Human +DTXSID7024457 TK.Half.Life NA 2.095 hours 1compartment NA NA Rat Human +DTXSID7024457 Css NA 0.02014 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024457 Css NA 0.1462 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024457 Css NA 0.01604 mg/L PBTK NA 50% Rat Human +DTXSID7024457 Css NA 0.09715 mg/L PBTK NA 95% Rat Human +DTXSID7024532 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024532 Fup 0.505 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024532 Vd NA 0.8999 L/kg 1compartment NA NA Human Human DTXSID7024532 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024532 TK.Half.Life NA 0.7262 hours 1compartment NA NA Human Human -DTXSID7024532 Css NA 0.009936 mg/L 3compartmentss NA 50% Human Human -DTXSID7024532 Css NA 0.1034 mg/L 3compartmentss NA 95% Human Human -DTXSID7024532 Css NA 0.008542 mg/L PBTK NA 50% Human Human -DTXSID7024532 Css NA 0.07367 mg/L PBTK NA 95% Human Human -DTXSID7024532 Clint NA 66.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024532 Fup NA 0.7292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024532 Vd NA 1.055 L/kg 1compartment NA NA Rat Human +DTXSID7024532 TK.Half.Life NA 0.8796 hours 1compartment NA NA Human Human +DTXSID7024532 Css NA 0.03752 mg/L 3compartmentss NA 50% Human Human +DTXSID7024532 Css NA 0.3378 mg/L 3compartmentss NA 95% Human Human +DTXSID7024532 Css NA 0.02998 mg/L PBTK NA 50% Human Human +DTXSID7024532 Css NA 0.2357 mg/L PBTK NA 95% Human Human +DTXSID7024532 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024532 Fup 0.505 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024532 Vd NA 0.8449 L/kg 1compartment NA NA Rat Human DTXSID7024532 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024532 TK.Half.Life NA 0.3107 hours 1compartment NA NA Rat Human -DTXSID7024532 Css NA 0.005044 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024532 Css NA 0.05028 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024532 Css NA 0.004304 mg/L PBTK NA 50% Rat Human -DTXSID7024532 Css NA 0.03515 mg/L PBTK NA 95% Rat Human -DTXSID7024534 Clint NA 229 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024534 Fup NA 0.0316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024534 Vd NA 0.4987 L/kg 1compartment NA NA Human Human -DTXSID7024534 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024534 TK.Half.Life NA 0.6925 hours 1compartment NA NA Human Human -DTXSID7024534 Css NA 0.09214 mg/L 3compartmentss NA 50% Human Human -DTXSID7024534 Css NA 0.998 mg/L 3compartmentss NA 95% Human Human -DTXSID7024534 Css NA 0.05932 mg/L PBTK NA 50% Human Human -DTXSID7024534 Css NA 0.6113 mg/L PBTK NA 95% Human Human -DTXSID7024534 Clint NA 229 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024534 Fup NA 0.0316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024534 Vd NA 0.4672 L/kg 1compartment NA NA Rat Human -DTXSID7024534 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024534 TK.Half.Life NA 0.3461 hours 1compartment NA NA Rat Human -DTXSID7024534 Css NA 0.05373 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024534 Css NA 0.4915 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024534 Css NA 0.0323 mg/L PBTK NA 50% Rat Human -DTXSID7024534 Css NA 0.2786 mg/L PBTK NA 95% Rat Human -DTXSID7024538 Clint NA 11.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024538 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024538 Vd NA 1.609 L/kg 1compartment NA NA Human Human -DTXSID7024538 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7024538 TK.Half.Life NA 13.25 hours 1compartment NA NA Human Human -DTXSID7024538 Css NA 1.203 mg/L 3compartmentss NA 50% Human Human -DTXSID7024538 Css NA 8.789 mg/L 3compartmentss NA 95% Human Human -DTXSID7024538 Css NA 0.7777 mg/L PBTK NA 50% Human Human -DTXSID7024538 Css NA 5.399 mg/L PBTK NA 95% Human Human -DTXSID7024538 Clint NA 11.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024538 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024538 Vd NA 1.207 L/kg 1compartment NA NA Rat Human +DTXSID7024532 TK.Half.Life NA 0.4146 hours 1compartment NA NA Rat Human +DTXSID7024532 Css NA 0.00455 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024532 Css NA 0.03387 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024532 Css NA 0.00366 mg/L PBTK NA 50% Rat Human +DTXSID7024532 Css NA 0.02266 mg/L PBTK NA 95% Rat Human +DTXSID7024538 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024538 Fup 0.0651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024538 Vd NA 1.528 L/kg 1compartment NA NA Human Human +DTXSID7024538 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7024538 TK.Half.Life NA 5.955 hours 1compartment NA NA Human Human +DTXSID7024538 Css NA 0.4666 mg/L 3compartmentss NA 50% Human Human +DTXSID7024538 Css NA 3.375 mg/L 3compartmentss NA 95% Human Human +DTXSID7024538 Css NA 0.3028 mg/L PBTK NA 50% Human Human +DTXSID7024538 Css NA 2.09 mg/L PBTK NA 95% Human Human +DTXSID7024538 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024538 Fup 0.0651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024538 Vd NA 1.153 L/kg 1compartment NA NA Rat Human DTXSID7024538 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024538 TK.Half.Life NA 4.912 hours 1compartment NA NA Rat Human -DTXSID7024538 Css NA 0.6728 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024538 Css NA 3.613 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024538 Css NA 0.4092 mg/L PBTK NA 50% Rat Human -DTXSID7024538 Css NA 2.093 mg/L PBTK NA 95% Rat Human -DTXSID7024580 Clint NA 11.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024580 Fup NA 0.0763 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024580 Vd NA 1.767 L/kg 1compartment NA NA Human Human +DTXSID7024538 TK.Half.Life NA 2.277 hours 1compartment NA NA Rat Human +DTXSID7024538 Css NA 0.06088 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024538 Css NA 0.333 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024538 Css NA 0.03858 mg/L PBTK NA 50% Rat Human +DTXSID7024538 Css NA 0.2038 mg/L PBTK NA 95% Rat Human +DTXSID7024580 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024580 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024580 Vd NA 1.595 L/kg 1compartment NA NA Human Human DTXSID7024580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024580 TK.Half.Life NA 10.83 hours 1compartment NA NA Human Human -DTXSID7024580 Css NA 0.8346 mg/L 3compartmentss NA 50% Human Human -DTXSID7024580 Css NA 5.674 mg/L 3compartmentss NA 95% Human Human -DTXSID7024580 Css NA 0.5523 mg/L PBTK NA 50% Human Human -DTXSID7024580 Css NA 3.546 mg/L PBTK NA 95% Human Human -DTXSID7024580 Clint NA 11.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024580 Fup NA 0.0763 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024580 Vd NA 1.335 L/kg 1compartment NA NA Rat Human +DTXSID7024580 TK.Half.Life NA 10.13 hours 1compartment NA NA Human Human +DTXSID7024580 Css NA 0.925 mg/L 3compartmentss NA 50% Human Human +DTXSID7024580 Css NA 6.812 mg/L 3compartmentss NA 95% Human Human +DTXSID7024580 Css NA 0.5846 mg/L PBTK NA 50% Human Human +DTXSID7024580 Css NA 4.166 mg/L PBTK NA 95% Human Human +DTXSID7024580 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024580 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024580 Vd NA 1.191 L/kg 1compartment NA NA Rat Human DTXSID7024580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024580 TK.Half.Life NA 3.844 hours 1compartment NA NA Rat Human -DTXSID7024580 Css NA 0.4583 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024580 Css NA 2.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024580 Css NA 0.2864 mg/L PBTK NA 50% Rat Human -DTXSID7024580 Css NA 1.356 mg/L PBTK NA 95% Rat Human +DTXSID7024580 TK.Half.Life NA 3.796 hours 1compartment NA NA Rat Human +DTXSID7024580 Css NA 0.1227 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024580 Css NA 0.6954 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024580 Css NA 0.07561 mg/L PBTK NA 50% Rat Human +DTXSID7024580 Css NA 0.4197 mg/L PBTK NA 95% Rat Human DTXSID7024586 Clint 18.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7024586 Fup NA 0.4171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024586 Vd NA 1.622 L/kg 1compartment NA NA Human Human +DTXSID7024586 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024586 Vd NA 1.097 L/kg 1compartment NA NA Human Human DTXSID7024586 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024586 TK.Half.Life NA 1.978 hours 1compartment NA NA Human Human -DTXSID7024586 Css NA 0.06487 mg/L 3compartmentss NA 50% Human Human -DTXSID7024586 Css NA 0.4749 mg/L 3compartmentss NA 95% Human Human -DTXSID7024586 Css NA 0.05235 mg/L PBTK NA 50% Human Human -DTXSID7024586 Css NA 0.3309 mg/L PBTK NA 95% Human Human +DTXSID7024586 TK.Half.Life NA 2.026 hours 1compartment NA NA Human Human +DTXSID7024586 Css NA 0.13 mg/L 3compartmentss NA 50% Human Human +DTXSID7024586 Css NA 0.885 mg/L 3compartmentss NA 95% Human Human +DTXSID7024586 Css NA 0.09191 mg/L PBTK NA 50% Human Human +DTXSID7024586 Css NA 0.5925 mg/L PBTK NA 95% Human Human DTXSID7024586 Clint 18.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7024586 Fup NA 0.4171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024586 Vd NA 1.332 L/kg 1compartment NA NA Rat Human +DTXSID7024586 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024586 Vd NA 0.893 L/kg 1compartment NA NA Rat Human DTXSID7024586 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024586 TK.Half.Life NA 0.7785 hours 1compartment NA NA Rat Human -DTXSID7024586 Css NA 0.03453 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024586 Css NA 0.1922 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024586 Css NA 0.02695 mg/L PBTK NA 50% Rat Human -DTXSID7024586 Css NA 0.1323 mg/L PBTK NA 95% Rat Human -DTXSID7024667 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024667 Fup NA 0.6317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024667 Vd NA 0.8664 L/kg 1compartment NA NA Human Human +DTXSID7024586 TK.Half.Life NA 0.8788 hours 1compartment NA NA Rat Human +DTXSID7024586 Css NA 0.01658 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024586 Css NA 0.0821 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024586 Css NA 0.0115 mg/L PBTK NA 50% Rat Human +DTXSID7024586 Css NA 0.05425 mg/L PBTK NA 95% Rat Human +DTXSID7024619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024619 Fup 0.00956 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024619 Vd NA 111.2 L/kg 1compartment NA NA Human Human +DTXSID7024619 Days.Css NA 864 Days PBTK NA NA Human Human +DTXSID7024619 TK.Half.Life NA 3290 hours 1compartment NA NA Human Human +DTXSID7024619 Css NA 0.1751 mg/L 3compartmentss NA 50% Human Human +DTXSID7024619 Css NA 1.118 mg/L 3compartmentss NA 95% Human Human +DTXSID7024619 Css NA 2.387 mg/L PBTK NA 50% Human Human +DTXSID7024619 Css NA 14.1 mg/L PBTK NA 95% Human Human +DTXSID7024619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024619 Fup 0.00956 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024619 Vd NA 96.44 L/kg 1compartment NA NA Rat Human +DTXSID7024619 Days.Css NA 542 Days PBTK NA NA Rat Human +DTXSID7024619 TK.Half.Life NA 500.1 hours 1compartment NA NA Rat Human +DTXSID7024619 Css NA 0.02074 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024619 Css NA 0.1007 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024619 Css NA 0.311 mg/L PBTK NA 50% Rat Human +DTXSID7024619 Css NA 1.563 mg/L PBTK NA 95% Rat Human +DTXSID7024667 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024667 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024667 Vd NA 0.6725 L/kg 1compartment NA NA Human Human DTXSID7024667 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024667 TK.Half.Life NA 9.036 hours 1compartment NA NA Human Human -DTXSID7024667 Css NA 1.132 mg/L 3compartmentss NA 50% Human Human -DTXSID7024667 Css NA 7.79 mg/L 3compartmentss NA 95% Human Human -DTXSID7024667 Css NA 0.9452 mg/L PBTK NA 50% Human Human -DTXSID7024667 Css NA 4.985 mg/L PBTK NA 95% Human Human -DTXSID7024667 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024667 Fup NA 0.6317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024667 Vd NA 0.8423 L/kg 1compartment NA NA Rat Human +DTXSID7024667 TK.Half.Life NA 7.226 hours 1compartment NA NA Human Human +DTXSID7024667 Css NA 1.19 mg/L 3compartmentss NA 50% Human Human +DTXSID7024667 Css NA 8.279 mg/L 3compartmentss NA 95% Human Human +DTXSID7024667 Css NA 0.9485 mg/L PBTK NA 50% Human Human +DTXSID7024667 Css NA 5.146 mg/L PBTK NA 95% Human Human +DTXSID7024667 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024667 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024667 Vd NA 0.6846 L/kg 1compartment NA NA Rat Human DTXSID7024667 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024667 TK.Half.Life NA 2.953 hours 1compartment NA NA Rat Human -DTXSID7024667 Css NA 0.3031 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024667 Css NA 1.815 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024667 Css NA 0.2425 mg/L PBTK NA 50% Rat Human -DTXSID7024667 Css NA 1.085 mg/L PBTK NA 95% Rat Human -DTXSID7024740 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024740 Fup NA 0.2689 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024740 Vd NA 0.4125 L/kg 1compartment NA NA Human Human -DTXSID7024740 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7024740 TK.Half.Life NA 9.932 hours 1compartment NA NA Human Human -DTXSID7024740 Css NA 2.934 mg/L 3compartmentss NA 50% Human Human -DTXSID7024740 Css NA 11.03 mg/L 3compartmentss NA 95% Human Human -DTXSID7024740 Css NA 1.985 mg/L PBTK NA 50% Human Human -DTXSID7024740 Css NA 6.825 mg/L PBTK NA 95% Human Human -DTXSID7024740 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024740 Fup NA 0.2689 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024740 Vd NA 0.4195 L/kg 1compartment NA NA Rat Human -DTXSID7024740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024740 TK.Half.Life NA 3.44 hours 1compartment NA NA Rat Human -DTXSID7024740 Css NA 0.8045 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024740 Css NA 2.554 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024740 Css NA 0.5165 mg/L PBTK NA 50% Rat Human -DTXSID7024740 Css NA 1.471 mg/L PBTK NA 95% Rat Human -DTXSID7024742 Clint NA 11800 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024742 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024742 Vd NA 99850 L/kg 1compartment NA NA Human Human -DTXSID7024742 Days.Css NA 1464 Days PBTK NA NA Human Human -DTXSID7024742 TK.Half.Life NA 5527 hours 1compartment NA NA Human Human -DTXSID7024742 Css NA 2.35e-07 mg/L 3compartmentss NA 50% Human Human -DTXSID7024742 Css NA 1.412e-06 mg/L 3compartmentss NA 95% Human Human -DTXSID7024742 Css NA 0.004613 mg/L PBTK NA 50% Human Human -DTXSID7024742 Css NA 0.02542 mg/L PBTK NA 95% Human Human -DTXSID7024742 Clint NA 11800 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024742 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024742 Vd NA 94930 L/kg 1compartment NA NA Rat Human -DTXSID7024742 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID7024742 TK.Half.Life NA 964.8 hours 1compartment NA NA Rat Human -DTXSID7024742 Css NA 1.18e-07 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024742 Css NA 5.27e-07 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024742 Css NA 0.002506 mg/L PBTK NA 50% Rat Human -DTXSID7024742 Css NA 0.01121 mg/L PBTK NA 95% Rat Human +DTXSID7024667 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human +DTXSID7024667 Css NA 0.07308 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024667 Css NA 0.4665 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024667 Css NA 0.05772 mg/L PBTK NA 50% Rat Human +DTXSID7024667 Css NA 0.2823 mg/L PBTK NA 95% Rat Human DTXSID7024827 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7024827 Fup 0.0235 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7024827 Vd NA 3.093 L/kg 1compartment NA NA Human Human -DTXSID7024827 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID7024827 TK.Half.Life NA 38360 hours 1compartment NA NA Human Human -DTXSID7024827 Css NA 11.59 mg/L 3compartmentss NA 50% Human Human -DTXSID7024827 Css NA 71.49 mg/L 3compartmentss NA 95% Human Human -DTXSID7024827 Css NA 7.972 mg/L PBTK NA 50% Human Human -DTXSID7024827 Css NA 48.11 mg/L PBTK NA 95% Human Human +DTXSID7024827 Vd NA 2.571 L/kg 1compartment NA NA Human Human +DTXSID7024827 Days.Css NA 616 Days PBTK NA NA Human Human +DTXSID7024827 TK.Half.Life NA 2344 hours 1compartment NA NA Human Human +DTXSID7024827 Css NA 4.813 mg/L 3compartmentss NA 50% Human Human +DTXSID7024827 Css NA 27.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7024827 Css NA 3.3 mg/L PBTK NA 50% Human Human +DTXSID7024827 Css NA 18.22 mg/L PBTK NA 95% Human Human DTXSID7024827 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7024827 Fup 0.0235 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7024827 Vd NA 2.317 L/kg 1compartment NA NA Rat Human -DTXSID7024827 Days.Css NA 2701 Days PBTK NA NA Rat Human -DTXSID7024827 TK.Half.Life NA 2500 hours 1compartment NA NA Rat Human -DTXSID7024827 Css NA 6.429 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024827 Css NA 33.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024827 Css NA 4.278 mg/L PBTK NA 50% Rat Human -DTXSID7024827 Css NA 21.06 mg/L PBTK NA 95% Rat Human +DTXSID7024827 Vd NA 1.944 L/kg 1compartment NA NA Rat Human +DTXSID7024827 Days.Css NA 157 Days PBTK NA NA Rat Human +DTXSID7024827 TK.Half.Life NA 282.9 hours 1compartment NA NA Rat Human +DTXSID7024827 Css NA 0.5894 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024827 Css NA 2.652 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024827 Css NA 0.3995 mg/L PBTK NA 50% Rat Human +DTXSID7024827 Css NA 1.707 mg/L PBTK NA 95% Rat Human DTXSID7024873 Clint NA 0.00213 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7024873 Fup NA 0.5825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024873 Vd NA 0.5683 L/kg 1compartment NA NA Human Human -DTXSID7024873 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024873 TK.Half.Life NA 6.29 hours 1compartment NA NA Human Human -DTXSID7024873 Css NA 1.308 mg/L 3compartmentss NA 50% Human Human -DTXSID7024873 Css NA 8.074 mg/L 3compartmentss NA 95% Human Human -DTXSID7024873 Css NA 0.9976 mg/L PBTK NA 50% Human Human -DTXSID7024873 Css NA 5.021 mg/L PBTK NA 95% Human Human +DTXSID7024873 Vd NA 1.269 L/kg 1compartment NA NA Human Human +DTXSID7024873 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7024873 TK.Half.Life NA 14.05 hours 1compartment NA NA Human Human +DTXSID7024873 Css NA 0.9638 mg/L 3compartmentss NA 50% Human Human +DTXSID7024873 Css NA 6.722 mg/L 3compartmentss NA 95% Human Human +DTXSID7024873 Css NA 0.8515 mg/L PBTK NA 50% Human Human +DTXSID7024873 Css NA 4.396 mg/L PBTK NA 95% Human Human DTXSID7024873 Clint NA 0.00213 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7024873 Fup NA 0.5825 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024873 Vd NA 0.5922 L/kg 1compartment NA NA Rat Human +DTXSID7024873 Vd NA 1.296 L/kg 1compartment NA NA Rat Human DTXSID7024873 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024873 TK.Half.Life NA 2.238 hours 1compartment NA NA Rat Human -DTXSID7024873 Css NA 0.3492 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024873 Css NA 2.204 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024873 Css NA 0.2552 mg/L PBTK NA 50% Rat Human -DTXSID7024873 Css NA 1.274 mg/L PBTK NA 95% Rat Human -DTXSID7024875 Clint NA 4.926 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024875 Fup NA 0.4465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024875 Vd NA 0.8779 L/kg 1compartment NA NA Human Human -DTXSID7024875 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024875 TK.Half.Life NA 1.896 hours 1compartment NA NA Human Human -DTXSID7024875 Css NA 0.1818 mg/L 3compartmentss NA 50% Human Human -DTXSID7024875 Css NA 1.223 mg/L 3compartmentss NA 95% Human Human -DTXSID7024875 Css NA 0.1436 mg/L PBTK NA 50% Human Human -DTXSID7024875 Css NA 0.8102 mg/L PBTK NA 95% Human Human -DTXSID7024875 Clint NA 4.926 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024875 Fup NA 0.4465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024875 Vd NA 0.8114 L/kg 1compartment NA NA Rat Human +DTXSID7024873 TK.Half.Life NA 4.899 hours 1compartment NA NA Rat Human +DTXSID7024873 Css NA 0.01799 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024873 Css NA 0.1711 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024873 Css NA 0.01569 mg/L PBTK NA 50% Rat Human +DTXSID7024873 Css NA 0.1124 mg/L PBTK NA 95% Rat Human +DTXSID7024875 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024875 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024875 Vd NA 1.192 L/kg 1compartment NA NA Human Human +DTXSID7024875 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7024875 TK.Half.Life NA 19.16 hours 1compartment NA NA Human Human +DTXSID7024875 Css NA 1.608 mg/L 3compartmentss NA 50% Human Human +DTXSID7024875 Css NA 7.304 mg/L 3compartmentss NA 95% Human Human +DTXSID7024875 Css NA 1.306 mg/L PBTK NA 50% Human Human +DTXSID7024875 Css NA 4.877 mg/L PBTK NA 95% Human Human +DTXSID7024875 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024875 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024875 Vd NA 1.037 L/kg 1compartment NA NA Rat Human DTXSID7024875 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024875 TK.Half.Life NA 0.9579 hours 1compartment NA NA Rat Human -DTXSID7024875 Css NA 0.08951 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024875 Css NA 0.474 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024875 Css NA 0.06792 mg/L PBTK NA 50% Rat Human -DTXSID7024875 Css NA 0.2964 mg/L PBTK NA 95% Rat Human +DTXSID7024875 TK.Half.Life NA 5.243 hours 1compartment NA NA Rat Human +DTXSID7024875 Css NA 0.1009 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024875 Css NA 0.4124 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024875 Css NA 0.08161 mg/L PBTK NA 50% Rat Human +DTXSID7024875 Css NA 0.2628 mg/L PBTK NA 95% Rat Human DTXSID7024902 Clint 12.42 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7024902 Fup 0.8914 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7024902 Vd NA 1.081 L/kg 1compartment NA NA Human Human DTXSID7024902 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7024902 TK.Half.Life NA 0.9042 hours 1compartment NA NA Human Human -DTXSID7024902 Css NA 0.0441 mg/L 3compartmentss NA 50% Human Human -DTXSID7024902 Css NA 0.3897 mg/L 3compartmentss NA 95% Human Human -DTXSID7024902 Css NA 0.038 mg/L PBTK NA 50% Human Human -DTXSID7024902 Css NA 0.2821 mg/L PBTK NA 95% Human Human +DTXSID7024902 Css NA 0.04092 mg/L 3compartmentss NA 50% Human Human +DTXSID7024902 Css NA 0.4216 mg/L 3compartmentss NA 95% Human Human +DTXSID7024902 Css NA 0.0357 mg/L PBTK NA 50% Human Human +DTXSID7024902 Css NA 0.3016 mg/L PBTK NA 95% Human Human DTXSID7024902 Clint 12.42 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7024902 Fup 0.8914 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7024902 Vd NA 1.051 L/kg 1compartment NA NA Rat Human DTXSID7024902 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7024902 TK.Half.Life NA 0.4398 hours 1compartment NA NA Rat Human -DTXSID7024902 Css NA 0.02134 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024902 Css NA 0.162 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024902 Css NA 0.01858 mg/L PBTK NA 50% Rat Human -DTXSID7024902 Css NA 0.1124 mg/L PBTK NA 95% Rat Human -DTXSID7024904 Clint NA 1.545 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024904 Fup NA 0.0027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024904 Vd NA 0.1762 L/kg 1compartment NA NA Human Human -DTXSID7024904 Days.Css NA 25 Days PBTK NA NA Human Human -DTXSID7024904 TK.Half.Life NA 117.2 hours 1compartment NA NA Human Human -DTXSID7024904 Css NA 120.2 mg/L 3compartmentss NA 50% Human Human -DTXSID7024904 Css NA 815.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7024904 Css NA 70.09 mg/L PBTK NA 50% Human Human -DTXSID7024904 Css NA 469.9 mg/L PBTK NA 95% Human Human -DTXSID7024904 Clint NA 1.545 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024904 Fup NA 0.0027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024904 Vd NA 0.1713 L/kg 1compartment NA NA Rat Human -DTXSID7024904 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID7024904 TK.Half.Life NA 61.83 hours 1compartment NA NA Rat Human -DTXSID7024904 Css NA 54.54 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024904 Css NA 307 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024904 Css NA 29.59 mg/L PBTK NA 50% Rat Human -DTXSID7024904 Css NA 165.9 mg/L PBTK NA 95% Rat Human -DTXSID7024906 Clint NA 4.629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024906 Fup NA 0.0867 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024906 Vd NA 0.6729 L/kg 1compartment NA NA Human Human -DTXSID7024906 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024906 TK.Half.Life NA 6.245 hours 1compartment NA NA Human Human -DTXSID7024906 Css NA 1.421 mg/L 3compartmentss NA 50% Human Human -DTXSID7024906 Css NA 9.222 mg/L 3compartmentss NA 95% Human Human -DTXSID7024906 Css NA 0.8976 mg/L PBTK NA 50% Human Human -DTXSID7024906 Css NA 5.473 mg/L PBTK NA 95% Human Human -DTXSID7024906 Clint NA 4.629 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024906 Fup NA 0.0867 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024906 Vd NA 0.5463 L/kg 1compartment NA NA Rat Human -DTXSID7024906 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024906 TK.Half.Life NA 2.963 hours 1compartment NA NA Rat Human -DTXSID7024906 Css NA 0.7435 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024906 Css NA 3.626 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024906 Css NA 0.4392 mg/L PBTK NA 50% Rat Human -DTXSID7024906 Css NA 2.025 mg/L PBTK NA 95% Rat Human -DTXSID7024950 Clint NA 1.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024950 Fup NA 0.2659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024950 Vd NA 1.315 L/kg 1compartment NA NA Human Human -DTXSID7024950 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7024950 TK.Half.Life NA 9.171 hours 1compartment NA NA Human Human -DTXSID7024950 Css NA 0.7561 mg/L 3compartmentss NA 50% Human Human -DTXSID7024950 Css NA 3.618 mg/L 3compartmentss NA 95% Human Human -DTXSID7024950 Css NA 0.5612 mg/L PBTK NA 50% Human Human -DTXSID7024950 Css NA 2.391 mg/L PBTK NA 95% Human Human -DTXSID7024950 Clint NA 1.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024950 Fup NA 0.2659 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024950 Vd NA 1.072 L/kg 1compartment NA NA Rat Human -DTXSID7024950 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7024950 TK.Half.Life NA 3.593 hours 1compartment NA NA Rat Human -DTXSID7024950 Css NA 0.3408 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024950 Css NA 1.226 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024950 Css NA 0.243 mg/L PBTK NA 50% Rat Human -DTXSID7024950 Css NA 0.759 mg/L PBTK NA 95% Rat Human -DTXSID7024956 Clint NA 11.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024956 Fup NA 0.0652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7024956 Vd NA 2.569 L/kg 1compartment NA NA Human Human -DTXSID7024956 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7024956 TK.Half.Life NA 27.85 hours 1compartment NA NA Human Human -DTXSID7024956 Css NA 1.39 mg/L 3compartmentss NA 50% Human Human -DTXSID7024956 Css NA 8.468 mg/L 3compartmentss NA 95% Human Human -DTXSID7024956 Css NA 0.9523 mg/L PBTK NA 50% Human Human -DTXSID7024956 Css NA 5.484 mg/L PBTK NA 95% Human Human -DTXSID7024956 Clint NA 11.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024956 Fup NA 0.0652 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7024956 Vd NA 1.933 L/kg 1compartment NA NA Rat Human -DTXSID7024956 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7024956 TK.Half.Life NA 6.684 hours 1compartment NA NA Rat Human -DTXSID7024956 Css NA 0.7714 mg/L 3compartmentss NA 50% Rat Human -DTXSID7024956 Css NA 3.446 mg/L 3compartmentss NA 95% Rat Human -DTXSID7024956 Css NA 0.5004 mg/L PBTK NA 50% Rat Human -DTXSID7024956 Css NA 2.14 mg/L PBTK NA 95% Rat Human -DTXSID7025001 Clint NA 13.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025001 Fup NA 0.0437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025001 Vd NA 0.977 L/kg 1compartment NA NA Human Human +DTXSID7024902 Css NA 0.004701 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024902 Css NA 0.03698 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024902 Css NA 0.00421 mg/L PBTK NA 50% Rat Human +DTXSID7024902 Css NA 0.02611 mg/L PBTK NA 95% Rat Human +DTXSID7024904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024904 Fup 0.0383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024904 Vd NA 1.981 L/kg 1compartment NA NA Human Human +DTXSID7024904 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7024904 TK.Half.Life NA 12.89 hours 1compartment NA NA Human Human +DTXSID7024904 Css NA 0.9095 mg/L 3compartmentss NA 50% Human Human +DTXSID7024904 Css NA 7.447 mg/L 3compartmentss NA 95% Human Human +DTXSID7024904 Css NA 0.5879 mg/L PBTK NA 50% Human Human +DTXSID7024904 Css NA 4.561 mg/L PBTK NA 95% Human Human +DTXSID7024904 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024904 Fup 0.0383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024904 Vd NA 1.48 L/kg 1compartment NA NA Rat Human +DTXSID7024904 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7024904 TK.Half.Life NA 4.216 hours 1compartment NA NA Rat Human +DTXSID7024904 Css NA 0.1176 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024904 Css NA 0.7494 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024904 Css NA 0.0746 mg/L PBTK NA 50% Rat Human +DTXSID7024904 Css NA 0.458 mg/L PBTK NA 95% Rat Human +DTXSID7024956 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024956 Fup 0.0978 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7024956 Vd NA 2.523 L/kg 1compartment NA NA Human Human +DTXSID7024956 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7024956 TK.Half.Life NA 11.35 hours 1compartment NA NA Human Human +DTXSID7024956 Css NA 0.506 mg/L 3compartmentss NA 50% Human Human +DTXSID7024956 Css NA 3.439 mg/L 3compartmentss NA 95% Human Human +DTXSID7024956 Css NA 0.3481 mg/L PBTK NA 50% Human Human +DTXSID7024956 Css NA 2.252 mg/L PBTK NA 95% Human Human +DTXSID7024956 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024956 Fup 0.0978 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7024956 Vd NA 1.909 L/kg 1compartment NA NA Rat Human +DTXSID7024956 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7024956 TK.Half.Life NA 2.981 hours 1compartment NA NA Rat Human +DTXSID7024956 Css NA 0.06426 mg/L 3compartmentss NA 50% Rat Human +DTXSID7024956 Css NA 0.3578 mg/L 3compartmentss NA 95% Rat Human +DTXSID7024956 Css NA 0.04366 mg/L PBTK NA 50% Rat Human +DTXSID7024956 Css NA 0.2391 mg/L PBTK NA 95% Rat Human +DTXSID7025001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025001 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025001 Vd NA 1.6 L/kg 1compartment NA NA Human Human DTXSID7025001 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025001 TK.Half.Life NA 7.144 hours 1compartment NA NA Human Human -DTXSID7025001 Css NA 1.126 mg/L 3compartmentss NA 50% Human Human -DTXSID7025001 Css NA 9.315 mg/L 3compartmentss NA 95% Human Human -DTXSID7025001 Css NA 0.6996 mg/L PBTK NA 50% Human Human -DTXSID7025001 Css NA 5.516 mg/L PBTK NA 95% Human Human -DTXSID7025001 Clint NA 13.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025001 Fup NA 0.0437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025001 Vd NA 0.7409 L/kg 1compartment NA NA Rat Human +DTXSID7025001 TK.Half.Life NA 4.056 hours 1compartment NA NA Human Human +DTXSID7025001 Css NA 0.251 mg/L 3compartmentss NA 50% Human Human +DTXSID7025001 Css NA 1.909 mg/L 3compartmentss NA 95% Human Human +DTXSID7025001 Css NA 0.1698 mg/L PBTK NA 50% Human Human +DTXSID7025001 Css NA 1.215 mg/L PBTK NA 95% Human Human +DTXSID7025001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025001 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025001 Vd NA 1.225 L/kg 1compartment NA NA Rat Human DTXSID7025001 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025001 TK.Half.Life NA 3.152 hours 1compartment NA NA Rat Human -DTXSID7025001 Css NA 0.6361 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025001 Css NA 4.03 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025001 Css NA 0.37 mg/L PBTK NA 50% Rat Human -DTXSID7025001 Css NA 2.23 mg/L PBTK NA 95% Rat Human -DTXSID7025003 Clint NA 5.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025003 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025003 Vd NA 1.301 L/kg 1compartment NA NA Human Human -DTXSID7025003 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7025003 TK.Half.Life NA 23.71 hours 1compartment NA NA Human Human -DTXSID7025003 Css NA 3.04 mg/L 3compartmentss NA 50% Human Human -DTXSID7025003 Css NA 22.47 mg/L 3compartmentss NA 95% Human Human -DTXSID7025003 Css NA 1.916 mg/L PBTK NA 50% Human Human -DTXSID7025003 Css NA 13.32 mg/L PBTK NA 95% Human Human -DTXSID7025003 Clint NA 5.174 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025003 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025003 Vd NA 0.9762 L/kg 1compartment NA NA Rat Human -DTXSID7025003 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7025003 TK.Half.Life NA 9.33 hours 1compartment NA NA Rat Human -DTXSID7025003 Css NA 1.607 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025003 Css NA 8.779 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025003 Css NA 0.9518 mg/L PBTK NA 50% Rat Human -DTXSID7025003 Css NA 4.884 mg/L PBTK NA 95% Rat Human -DTXSID7025005 Clint NA 4.874 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025005 Fup NA 0.1037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025005 Vd NA 2.34 L/kg 1compartment NA NA Human Human -DTXSID7025005 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7025005 TK.Half.Life NA 31.49 hours 1compartment NA NA Human Human -DTXSID7025005 Css NA 1.816 mg/L 3compartmentss NA 50% Human Human -DTXSID7025005 Css NA 9.747 mg/L 3compartmentss NA 95% Human Human -DTXSID7025005 Css NA 1.248 mg/L PBTK NA 50% Human Human -DTXSID7025005 Css NA 6.429 mg/L PBTK NA 95% Human Human -DTXSID7025005 Clint NA 4.874 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025005 Fup NA 0.1037 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025005 Vd NA 1.766 L/kg 1compartment NA NA Rat Human -DTXSID7025005 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7025005 TK.Half.Life NA 8.304 hours 1compartment NA NA Rat Human -DTXSID7025005 Css NA 0.9378 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025005 Css NA 3.709 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025005 Css NA 0.6123 mg/L PBTK NA 50% Rat Human -DTXSID7025005 Css NA 2.277 mg/L PBTK NA 95% Rat Human -DTXSID7025051 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025051 Fup NA 0.6971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025051 Vd NA 0.9421 L/kg 1compartment NA NA Human Human +DTXSID7025001 TK.Half.Life NA 1.524 hours 1compartment NA NA Rat Human +DTXSID7025001 Css NA 0.03237 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025001 Css NA 0.1892 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025001 Css NA 0.02142 mg/L PBTK NA 50% Rat Human +DTXSID7025001 Css NA 0.118 mg/L PBTK NA 95% Rat Human +DTXSID7025003 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025003 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025003 Vd NA 2.01 L/kg 1compartment NA NA Human Human +DTXSID7025003 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7025003 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human +DTXSID7025003 Css NA 0.3114 mg/L 3compartmentss NA 50% Human Human +DTXSID7025003 Css NA 2.249 mg/L 3compartmentss NA 95% Human Human +DTXSID7025003 Css NA 0.2122 mg/L PBTK NA 50% Human Human +DTXSID7025003 Css NA 1.459 mg/L PBTK NA 95% Human Human +DTXSID7025003 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025003 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025003 Vd NA 1.526 L/kg 1compartment NA NA Rat Human +DTXSID7025003 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7025003 TK.Half.Life NA 2 hours 1compartment NA NA Rat Human +DTXSID7025003 Css NA 0.04005 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025003 Css NA 0.2293 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025003 Css NA 0.02681 mg/L PBTK NA 50% Rat Human +DTXSID7025003 Css NA 0.145 mg/L PBTK NA 95% Rat Human +DTXSID7025005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025005 Fup 0.0956 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025005 Vd NA 2.29 L/kg 1compartment NA NA Human Human +DTXSID7025005 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7025005 TK.Half.Life NA 9.044 hours 1compartment NA NA Human Human +DTXSID7025005 Css NA 0.4422 mg/L 3compartmentss NA 50% Human Human +DTXSID7025005 Css NA 3.068 mg/L 3compartmentss NA 95% Human Human +DTXSID7025005 Css NA 0.3 mg/L PBTK NA 50% Human Human +DTXSID7025005 Css NA 1.981 mg/L PBTK NA 95% Human Human +DTXSID7025005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025005 Fup 0.0956 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025005 Vd NA 1.728 L/kg 1compartment NA NA Rat Human +DTXSID7025005 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7025005 TK.Half.Life NA 2.649 hours 1compartment NA NA Rat Human +DTXSID7025005 Css NA 0.05669 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025005 Css NA 0.3047 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025005 Css NA 0.03806 mg/L PBTK NA 50% Rat Human +DTXSID7025005 Css NA 0.1989 mg/L PBTK NA 95% Rat Human +DTXSID7025051 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025051 Fup 0.729 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025051 Vd NA 0.9681 L/kg 1compartment NA NA Human Human DTXSID7025051 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025051 TK.Half.Life NA 8.946 hours 1compartment NA NA Human Human -DTXSID7025051 Css NA 1.056 mg/L 3compartmentss NA 50% Human Human -DTXSID7025051 Css NA 7.023 mg/L 3compartmentss NA 95% Human Human -DTXSID7025051 Css NA 0.9004 mg/L PBTK NA 50% Human Human -DTXSID7025051 Css NA 4.447 mg/L PBTK NA 95% Human Human -DTXSID7025051 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025051 Fup NA 0.6971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025051 Vd NA 0.9119 L/kg 1compartment NA NA Rat Human +DTXSID7025051 TK.Half.Life NA 8.801 hours 1compartment NA NA Human Human +DTXSID7025051 Css NA 0.9784 mg/L 3compartmentss NA 50% Human Human +DTXSID7025051 Css NA 6.56 mg/L 3compartmentss NA 95% Human Human +DTXSID7025051 Css NA 0.842 mg/L PBTK NA 50% Human Human +DTXSID7025051 Css NA 4.288 mg/L PBTK NA 95% Human Human +DTXSID7025051 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025051 Fup 0.729 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025051 Vd NA 0.9369 L/kg 1compartment NA NA Rat Human DTXSID7025051 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025051 TK.Half.Life NA 2.899 hours 1compartment NA NA Rat Human -DTXSID7025051 Css NA 0.2752 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025051 Css NA 1.806 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025051 Css NA 0.2264 mg/L PBTK NA 50% Rat Human -DTXSID7025051 Css NA 1.082 mg/L PBTK NA 95% Rat Human -DTXSID7025053 Clint NA 106.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025053 Fup NA 0.0572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025053 Vd NA 5.024 L/kg 1compartment NA NA Human Human -DTXSID7025053 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025053 TK.Half.Life NA 2.203 hours 1compartment NA NA Human Human -DTXSID7025053 Css NA 0.001846 mg/L 3compartmentss NA 50% Human Human -DTXSID7025053 Css NA 0.01847 mg/L 3compartmentss NA 95% Human Human -DTXSID7025053 Css NA 0.00222 mg/L PBTK NA 50% Human Human -DTXSID7025053 Css NA 0.01755 mg/L PBTK NA 95% Human Human -DTXSID7025053 Clint NA 106.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025053 Fup NA 0.0572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025053 Vd NA 4.373 L/kg 1compartment NA NA Rat Human -DTXSID7025053 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025053 TK.Half.Life NA 0.8479 hours 1compartment NA NA Rat Human -DTXSID7025053 Css NA 0.001004 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025053 Css NA 0.009014 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025053 Css NA 0.001194 mg/L PBTK NA 50% Rat Human -DTXSID7025053 Css NA 0.007856 mg/L PBTK NA 95% Rat Human -DTXSID7025055 Clint NA 394.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025055 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025055 Vd NA 1111 L/kg 1compartment NA NA Human Human -DTXSID7025055 Days.Css NA 456 Days PBTK NA NA Human Human -DTXSID7025055 TK.Half.Life NA 1826 hours 1compartment NA NA Human Human -DTXSID7025055 Css NA 0.0007708 mg/L 3compartmentss NA 50% Human Human -DTXSID7025055 Css NA 0.004812 mg/L 3compartmentss NA 95% Human Human -DTXSID7025055 Css NA 0.1362 mg/L PBTK NA 50% Human Human -DTXSID7025055 Css NA 0.7673 mg/L PBTK NA 95% Human Human -DTXSID7025055 Clint NA 394.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025055 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025055 Vd NA 1019 L/kg 1compartment NA NA Rat Human -DTXSID7025055 Days.Css NA 315 Days PBTK NA NA Rat Human -DTXSID7025055 TK.Half.Life NA 301 hours 1compartment NA NA Rat Human -DTXSID7025055 Css NA 0.0003892 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025055 Css NA 0.00174 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025055 Css NA 0.07454 mg/L PBTK NA 50% Rat Human -DTXSID7025055 Css NA 0.3271 mg/L PBTK NA 95% Rat Human -DTXSID7025130 Clint NA 12.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025130 Fup NA 0.0564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025130 Vd NA 2.957 L/kg 1compartment NA NA Human Human -DTXSID7025130 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID7025130 TK.Half.Life NA 59.65 hours 1compartment NA NA Human Human -DTXSID7025130 Css NA 2.535 mg/L 3compartmentss NA 50% Human Human -DTXSID7025130 Css NA 15.13 mg/L 3compartmentss NA 95% Human Human -DTXSID7025130 Css NA 1.755 mg/L PBTK NA 50% Human Human -DTXSID7025130 Css NA 10.24 mg/L PBTK NA 95% Human Human -DTXSID7025130 Clint NA 12.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025130 Fup NA 0.0564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025130 Vd NA 2.218 L/kg 1compartment NA NA Rat Human -DTXSID7025130 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID7025130 TK.Half.Life NA 9.938 hours 1compartment NA NA Rat Human -DTXSID7025130 Css NA 1.404 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025130 Css NA 6.872 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025130 Css NA 0.9245 mg/L PBTK NA 50% Rat Human -DTXSID7025130 Css NA 4.441 mg/L PBTK NA 95% Rat Human +DTXSID7025051 TK.Half.Life NA 2.85 hours 1compartment NA NA Rat Human +DTXSID7025051 Css NA 0.05876 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025051 Css NA 0.3719 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025051 Css NA 0.05077 mg/L PBTK NA 50% Rat Human +DTXSID7025051 Css NA 0.2328 mg/L PBTK NA 95% Rat Human DTXSID7025132 Clint 523 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7025132 Fup 3.21e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7025132 Vd NA 0.1701 L/kg 1compartment NA NA Human Human DTXSID7025132 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID7025132 TK.Half.Life NA 10.6 hours 1compartment NA NA Human Human -DTXSID7025132 Css NA 3.791 mg/L 3compartmentss NA 50% Human Human -DTXSID7025132 Css NA 32.88 mg/L 3compartmentss NA 95% Human Human -DTXSID7025132 Css NA 2.234 mg/L PBTK NA 50% Human Human -DTXSID7025132 Css NA 18.93 mg/L PBTK NA 95% Human Human +DTXSID7025132 Css NA 3.75 mg/L 3compartmentss NA 50% Human Human +DTXSID7025132 Css NA 33.44 mg/L 3compartmentss NA 95% Human Human +DTXSID7025132 Css NA 2.194 mg/L PBTK NA 50% Human Human +DTXSID7025132 Css NA 19.62 mg/L PBTK NA 95% Human Human DTXSID7025132 Clint 523 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7025132 Fup 3.21e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7025132 Vd NA 0.1631 L/kg 1compartment NA NA Rat Human DTXSID7025132 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7025132 TK.Half.Life NA 7.088 hours 1compartment NA NA Rat Human -DTXSID7025132 Css NA 2.62 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025132 Css NA 14.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025132 Css NA 1.416 mg/L PBTK NA 50% Rat Human -DTXSID7025132 Css NA 7.808 mg/L PBTK NA 95% Rat Human -DTXSID7025134 Clint NA 3.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025134 Fup NA 0.2998 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025134 Vd NA 2.551 L/kg 1compartment NA NA Human Human -DTXSID7025134 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7025134 TK.Half.Life NA 23.03 hours 1compartment NA NA Human Human -DTXSID7025134 Css NA 0.994 mg/L 3compartmentss NA 50% Human Human -DTXSID7025134 Css NA 4.445 mg/L 3compartmentss NA 95% Human Human -DTXSID7025134 Css NA 0.7437 mg/L PBTK NA 50% Human Human -DTXSID7025134 Css NA 3.131 mg/L PBTK NA 95% Human Human -DTXSID7025134 Clint NA 3.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025134 Fup NA 0.2998 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025134 Vd NA 1.959 L/kg 1compartment NA NA Rat Human -DTXSID7025134 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7025134 TK.Half.Life NA 5.436 hours 1compartment NA NA Rat Human -DTXSID7025134 Css NA 0.4824 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025134 Css NA 1.513 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025134 Css NA 0.3489 mg/L PBTK NA 50% Rat Human -DTXSID7025134 Css NA 1.001 mg/L PBTK NA 95% Rat Human -DTXSID7025136 Clint NA 6.228 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025136 Fup NA 0.2676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025136 Vd NA 2.346 L/kg 1compartment NA NA Human Human +DTXSID7025132 Css NA 0.5897 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025132 Css NA 3.497 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025132 Css NA 0.33 mg/L PBTK NA 50% Rat Human +DTXSID7025132 Css NA 1.955 mg/L PBTK NA 95% Rat Human +DTXSID7025134 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025134 Fup 0.0608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025134 Vd NA 1.484 L/kg 1compartment NA NA Human Human +DTXSID7025134 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7025134 TK.Half.Life NA 6.017 hours 1compartment NA NA Human Human +DTXSID7025134 Css NA 0.5066 mg/L 3compartmentss NA 50% Human Human +DTXSID7025134 Css NA 3.87 mg/L 3compartmentss NA 95% Human Human +DTXSID7025134 Css NA 0.329 mg/L PBTK NA 50% Human Human +DTXSID7025134 Css NA 2.377 mg/L PBTK NA 95% Human Human +DTXSID7025134 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025134 Fup 0.0608 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025134 Vd NA 1.121 L/kg 1compartment NA NA Rat Human +DTXSID7025134 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7025134 TK.Half.Life NA 2.333 hours 1compartment NA NA Rat Human +DTXSID7025134 Css NA 0.06659 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025134 Css NA 0.3843 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025134 Css NA 0.04177 mg/L PBTK NA 50% Rat Human +DTXSID7025134 Css NA 0.2312 mg/L PBTK NA 95% Rat Human +DTXSID7025136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025136 Fup 0.062 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025136 Vd NA 1.337 L/kg 1compartment NA NA Human Human DTXSID7025136 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025136 TK.Half.Life NA 11.21 hours 1compartment NA NA Human Human -DTXSID7025136 Css NA 0.4892 mg/L 3compartmentss NA 50% Human Human -DTXSID7025136 Css NA 2.682 mg/L 3compartmentss NA 95% Human Human -DTXSID7025136 Css NA 0.3627 mg/L PBTK NA 50% Human Human -DTXSID7025136 Css NA 1.853 mg/L PBTK NA 95% Human Human -DTXSID7025136 Clint NA 6.228 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025136 Fup NA 0.2676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025136 Vd NA 1.807 L/kg 1compartment NA NA Rat Human +DTXSID7025136 TK.Half.Life NA 5.188 hours 1compartment NA NA Human Human +DTXSID7025136 Css NA 0.5134 mg/L 3compartmentss NA 50% Human Human +DTXSID7025136 Css NA 4.046 mg/L 3compartmentss NA 95% Human Human +DTXSID7025136 Css NA 0.3272 mg/L PBTK NA 50% Human Human +DTXSID7025136 Css NA 2.498 mg/L PBTK NA 95% Human Human +DTXSID7025136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025136 Fup 0.062 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025136 Vd NA 1.014 L/kg 1compartment NA NA Rat Human DTXSID7025136 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025136 TK.Half.Life NA 3.19 hours 1compartment NA NA Rat Human -DTXSID7025136 Css NA 0.2499 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025136 Css NA 0.9518 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025136 Css NA 0.1801 mg/L PBTK NA 50% Rat Human -DTXSID7025136 Css NA 0.6394 mg/L PBTK NA 95% Rat Human -DTXSID7025138 Clint NA 25.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025138 Fup NA 0.4914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025138 Vd NA 1.78 L/kg 1compartment NA NA Human Human +DTXSID7025136 TK.Half.Life NA 2.094 hours 1compartment NA NA Rat Human +DTXSID7025136 Css NA 0.06638 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025136 Css NA 0.4071 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025136 Css NA 0.04126 mg/L PBTK NA 50% Rat Human +DTXSID7025136 Css NA 0.2424 mg/L PBTK NA 95% Rat Human +DTXSID7025138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025138 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025138 Vd NA 1.685 L/kg 1compartment NA NA Human Human DTXSID7025138 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025138 TK.Half.Life NA 1.79 hours 1compartment NA NA Human Human -DTXSID7025138 Css NA 0.0431 mg/L 3compartmentss NA 50% Human Human -DTXSID7025138 Css NA 0.3383 mg/L 3compartmentss NA 95% Human Human -DTXSID7025138 Css NA 0.03595 mg/L PBTK NA 50% Human Human -DTXSID7025138 Css NA 0.2453 mg/L PBTK NA 95% Human Human -DTXSID7025138 Clint NA 25.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025138 Fup NA 0.4914 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025138 Vd NA 1.461 L/kg 1compartment NA NA Rat Human +DTXSID7025138 TK.Half.Life NA 1.921 hours 1compartment NA NA Human Human +DTXSID7025138 Css NA 0.05271 mg/L 3compartmentss NA 50% Human Human +DTXSID7025138 Css NA 0.416 mg/L 3compartmentss NA 95% Human Human +DTXSID7025138 Css NA 0.04297 mg/L PBTK NA 50% Human Human +DTXSID7025138 Css NA 0.3031 mg/L PBTK NA 95% Human Human +DTXSID7025138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025138 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025138 Vd NA 1.38 L/kg 1compartment NA NA Rat Human DTXSID7025138 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025138 TK.Half.Life NA 0.6776 hours 1compartment NA NA Rat Human -DTXSID7025138 Css NA 0.02249 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025138 Css NA 0.1515 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025138 Css NA 0.01819 mg/L PBTK NA 50% Rat Human -DTXSID7025138 Css NA 0.1037 mg/L PBTK NA 95% Rat Human -DTXSID7025180 Clint NA 6.982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025180 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025180 Vd NA 1.275 L/kg 1compartment NA NA Human Human -DTXSID7025180 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7025180 TK.Half.Life NA 14.17 hours 1compartment NA NA Human Human -DTXSID7025180 Css NA 1.732 mg/L 3compartmentss NA 50% Human Human -DTXSID7025180 Css NA 12.18 mg/L 3compartmentss NA 95% Human Human -DTXSID7025180 Css NA 1.1 mg/L PBTK NA 50% Human Human -DTXSID7025180 Css NA 7.337 mg/L PBTK NA 95% Human Human -DTXSID7025180 Clint NA 6.982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025180 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025180 Vd NA 0.9639 L/kg 1compartment NA NA Rat Human -DTXSID7025180 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025180 TK.Half.Life NA 5.743 hours 1compartment NA NA Rat Human -DTXSID7025180 Css NA 0.9366 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025180 Css NA 4.846 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025180 Css NA 0.5579 mg/L PBTK NA 50% Rat Human -DTXSID7025180 Css NA 2.723 mg/L PBTK NA 95% Rat Human -DTXSID7025215 Clint NA 184.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025215 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025215 Vd NA 676.6 L/kg 1compartment NA NA Human Human -DTXSID7025215 Days.Css NA 618 Days PBTK NA NA Human Human -DTXSID7025215 TK.Half.Life NA 2408 hours 1compartment NA NA Human Human -DTXSID7025215 Css NA 0.002847 mg/L 3compartmentss NA 50% Human Human -DTXSID7025215 Css NA 0.01777 mg/L 3compartmentss NA 95% Human Human -DTXSID7025215 Css NA 0.2955 mg/L PBTK NA 50% Human Human -DTXSID7025215 Css NA 1.675 mg/L PBTK NA 95% Human Human -DTXSID7025215 Clint NA 184.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025215 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025215 Vd NA 615.1 L/kg 1compartment NA NA Rat Human -DTXSID7025215 Days.Css NA 414 Days PBTK NA NA Rat Human -DTXSID7025215 TK.Half.Life NA 409.9 hours 1compartment NA NA Rat Human -DTXSID7025215 Css NA 0.001452 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025215 Css NA 0.006067 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025215 Css NA 0.161 mg/L PBTK NA 50% Rat Human -DTXSID7025215 Css NA 0.6776 mg/L PBTK NA 95% Rat Human -DTXSID7025217 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025217 Fup NA 0.0515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025217 Vd NA 2.119 L/kg 1compartment NA NA Human Human -DTXSID7025217 Days.Css NA 136 Days PBTK NA NA Human Human -DTXSID7025217 TK.Half.Life NA 561.3 hours 1compartment NA NA Human Human -DTXSID7025217 Css NA 37 mg/L 3compartmentss NA 50% Human Human -DTXSID7025217 Css NA 137.9 mg/L 3compartmentss NA 95% Human Human -DTXSID7025217 Css NA 24.54 mg/L PBTK NA 50% Human Human -DTXSID7025217 Css NA 84.75 mg/L PBTK NA 95% Human Human -DTXSID7025217 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025217 Fup NA 0.0515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025217 Vd NA 1.588 L/kg 1compartment NA NA Rat Human -DTXSID7025217 Days.Css NA 32 Days PBTK NA NA Rat Human -DTXSID7025217 TK.Half.Life NA 86 hours 1compartment NA NA Rat Human -DTXSID7025217 Css NA 10.32 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025217 Css NA 32.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025217 Css NA 6.443 mg/L PBTK NA 50% Rat Human -DTXSID7025217 Css NA 18.27 mg/L PBTK NA 95% Rat Human -DTXSID7025219 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025219 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025219 Vd NA 0.5326 L/kg 1compartment NA NA Human Human -DTXSID7025219 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025219 TK.Half.Life NA 9.524 hours 1compartment NA NA Human Human -DTXSID7025219 Css NA 3.125 mg/L 3compartmentss NA 50% Human Human -DTXSID7025219 Css NA 32.01 mg/L 3compartmentss NA 95% Human Human -DTXSID7025219 Css NA 1.898 mg/L PBTK NA 50% Human Human -DTXSID7025219 Css NA 18.94 mg/L PBTK NA 95% Human Human -DTXSID7025219 Clint NA 35.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025219 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025219 Vd NA 0.4356 L/kg 1compartment NA NA Rat Human -DTXSID7025219 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025219 TK.Half.Life NA 5.154 hours 1compartment NA NA Rat Human -DTXSID7025219 Css NA 1.819 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025219 Css NA 15.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025219 Css NA 1.034 mg/L PBTK NA 50% Rat Human -DTXSID7025219 Css NA 8.561 mg/L PBTK NA 95% Rat Human -DTXSID7025269 Clint NA 1.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025269 Fup NA 0.3247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025269 Vd NA 2.606 L/kg 1compartment NA NA Human Human -DTXSID7025269 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID7025269 TK.Half.Life NA 48.37 hours 1compartment NA NA Human Human -DTXSID7025269 Css NA 2.021 mg/L 3compartmentss NA 50% Human Human -DTXSID7025269 Css NA 7.711 mg/L 3compartmentss NA 95% Human Human -DTXSID7025269 Css NA 1.541 mg/L PBTK NA 50% Human Human -DTXSID7025269 Css NA 5.314 mg/L PBTK NA 95% Human Human -DTXSID7025269 Clint NA 1.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025269 Fup NA 0.3247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025269 Vd NA 2.014 L/kg 1compartment NA NA Rat Human -DTXSID7025269 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7025269 TK.Half.Life NA 9.749 hours 1compartment NA NA Rat Human -DTXSID7025269 Css NA 0.8516 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025269 Css NA 2.336 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025269 Css NA 0.6267 mg/L PBTK NA 50% Rat Human -DTXSID7025269 Css NA 1.507 mg/L PBTK NA 95% Rat Human -DTXSID7025346 Clint NA 9.232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025346 Fup NA 0.801 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025346 Vd NA 1.831 L/kg 1compartment NA NA Human Human +DTXSID7025138 TK.Half.Life NA 0.7427 hours 1compartment NA NA Rat Human +DTXSID7025138 Css NA 0.006574 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025138 Css NA 0.03848 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025138 Css NA 0.005327 mg/L PBTK NA 50% Rat Human +DTXSID7025138 Css NA 0.02809 mg/L PBTK NA 95% Rat Human +DTXSID7025180 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025180 Fup 0.0343 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025180 Vd NA 2.919 L/kg 1compartment NA NA Human Human +DTXSID7025180 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7025180 TK.Half.Life NA 41.14 hours 1compartment NA NA Human Human +DTXSID7025180 Css NA 1.723 mg/L 3compartmentss NA 50% Human Human +DTXSID7025180 Css NA 11.41 mg/L 3compartmentss NA 95% Human Human +DTXSID7025180 Css NA 1.177 mg/L PBTK NA 50% Human Human +DTXSID7025180 Css NA 7.405 mg/L PBTK NA 95% Human Human +DTXSID7025180 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025180 Fup 0.0343 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025180 Vd NA 2.186 L/kg 1compartment NA NA Rat Human +DTXSID7025180 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7025180 TK.Half.Life NA 7.281 hours 1compartment NA NA Rat Human +DTXSID7025180 Css NA 0.227 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025180 Css NA 1.193 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025180 Css NA 0.1535 mg/L PBTK NA 50% Rat Human +DTXSID7025180 Css NA 0.7927 mg/L PBTK NA 95% Rat Human +DTXSID7025217 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025217 Fup 0.0923 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025217 Vd NA 0.9517 L/kg 1compartment NA NA Human Human +DTXSID7025217 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7025217 TK.Half.Life NA 2.632 hours 1compartment NA NA Human Human +DTXSID7025217 Css NA 0.3109 mg/L 3compartmentss NA 50% Human Human +DTXSID7025217 Css NA 2.377 mg/L 3compartmentss NA 95% Human Human +DTXSID7025217 Css NA 0.1992 mg/L PBTK NA 50% Human Human +DTXSID7025217 Css NA 1.457 mg/L PBTK NA 95% Human Human +DTXSID7025217 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025217 Fup 0.0923 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025217 Vd NA 0.7496 L/kg 1compartment NA NA Rat Human +DTXSID7025217 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7025217 TK.Half.Life NA 1.166 hours 1compartment NA NA Rat Human +DTXSID7025217 Css NA 0.03993 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025217 Css NA 0.2585 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025217 Css NA 0.0251 mg/L PBTK NA 50% Rat Human +DTXSID7025217 Css NA 0.1551 mg/L PBTK NA 95% Rat Human +DTXSID7025269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025269 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025269 Vd NA 2.341 L/kg 1compartment NA NA Human Human +DTXSID7025269 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7025269 TK.Half.Life NA 6.012 hours 1compartment NA NA Human Human +DTXSID7025269 Css NA 0.2172 mg/L 3compartmentss NA 50% Human Human +DTXSID7025269 Css NA 1.453 mg/L 3compartmentss NA 95% Human Human +DTXSID7025269 Css NA 0.1552 mg/L PBTK NA 50% Human Human +DTXSID7025269 Css NA 1.005 mg/L PBTK NA 95% Human Human +DTXSID7025269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025269 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025269 Vd NA 1.794 L/kg 1compartment NA NA Rat Human +DTXSID7025269 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7025269 TK.Half.Life NA 1.815 hours 1compartment NA NA Rat Human +DTXSID7025269 Css NA 0.02717 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025269 Css NA 0.1382 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025269 Css NA 0.01953 mg/L PBTK NA 50% Rat Human +DTXSID7025269 Css NA 0.09598 mg/L PBTK NA 95% Rat Human +DTXSID7025346 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025346 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025346 Vd NA 1.325 L/kg 1compartment NA NA Human Human DTXSID7025346 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025346 TK.Half.Life NA 2.023 hours 1compartment NA NA Human Human -DTXSID7025346 Css NA 0.0649 mg/L 3compartmentss NA 50% Human Human -DTXSID7025346 Css NA 0.5703 mg/L 3compartmentss NA 95% Human Human -DTXSID7025346 Css NA 0.06004 mg/L PBTK NA 50% Human Human -DTXSID7025346 Css NA 0.429 mg/L PBTK NA 95% Human Human -DTXSID7025346 Clint NA 9.232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025346 Fup NA 0.801 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025346 Vd NA 1.567 L/kg 1compartment NA NA Rat Human +DTXSID7025346 TK.Half.Life NA 1.449 hours 1compartment NA NA Human Human +DTXSID7025346 Css NA 0.04797 mg/L 3compartmentss NA 50% Human Human +DTXSID7025346 Css NA 0.4028 mg/L 3compartmentss NA 95% Human Human +DTXSID7025346 Css NA 0.03838 mg/L PBTK NA 50% Human Human +DTXSID7025346 Css NA 0.2895 mg/L PBTK NA 95% Human Human +DTXSID7025346 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025346 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025346 Vd NA 1.124 L/kg 1compartment NA NA Rat Human DTXSID7025346 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025346 TK.Half.Life NA 0.816 hours 1compartment NA NA Rat Human -DTXSID7025346 Css NA 0.03251 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025346 Css NA 0.2458 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025346 Css NA 0.02962 mg/L PBTK NA 50% Rat Human -DTXSID7025346 Css NA 0.1697 mg/L PBTK NA 95% Rat Human -DTXSID7025390 Clint NA 71.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025390 Fup NA 0.0472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025390 Vd NA 6.257 L/kg 1compartment NA NA Human Human -DTXSID7025390 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025390 TK.Half.Life NA 2.793 hours 1compartment NA NA Human Human -DTXSID7025390 Css NA 0.003577 mg/L 3compartmentss NA 50% Human Human -DTXSID7025390 Css NA 0.03642 mg/L 3compartmentss NA 95% Human Human -DTXSID7025390 Css NA 0.004391 mg/L PBTK NA 50% Human Human -DTXSID7025390 Css NA 0.03433 mg/L PBTK NA 95% Human Human -DTXSID7025390 Clint NA 71.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025390 Fup NA 0.0472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025390 Vd NA 5.358 L/kg 1compartment NA NA Rat Human -DTXSID7025390 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025390 TK.Half.Life NA 1.061 hours 1compartment NA NA Rat Human -DTXSID7025390 Css NA 0.001975 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025390 Css NA 0.01677 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025390 Css NA 0.002411 mg/L PBTK NA 50% Rat Human -DTXSID7025390 Css NA 0.01531 mg/L PBTK NA 95% Rat Human -DTXSID7025394 Clint NA 3.229 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025394 Fup NA 0.9441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025394 Vd NA 0.7289 L/kg 1compartment NA NA Human Human +DTXSID7025346 TK.Half.Life NA 0.6064 hours 1compartment NA NA Rat Human +DTXSID7025346 Css NA 0.005936 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025346 Css NA 0.03689 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025346 Css NA 0.004785 mg/L PBTK NA 50% Rat Human +DTXSID7025346 Css NA 0.02606 mg/L PBTK NA 95% Rat Human +DTXSID7025394 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025394 Fup 0.633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025394 Vd NA 0.5878 L/kg 1compartment NA NA Human Human DTXSID7025394 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025394 TK.Half.Life NA 1.084 hours 1compartment NA NA Human Human -DTXSID7025394 Css NA 0.1413 mg/L 3compartmentss NA 50% Human Human -DTXSID7025394 Css NA 0.7259 mg/L 3compartmentss NA 95% Human Human -DTXSID7025394 Css NA 0.1152 mg/L PBTK NA 50% Human Human -DTXSID7025394 Css NA 0.5224 mg/L PBTK NA 95% Human Human -DTXSID7025394 Clint NA 3.229 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025394 Fup NA 0.9441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025394 Vd NA 0.769 L/kg 1compartment NA NA Rat Human +DTXSID7025394 TK.Half.Life NA 6.012 hours 1compartment NA NA Human Human +DTXSID7025394 Css NA 1.163 mg/L 3compartmentss NA 50% Human Human +DTXSID7025394 Css NA 7.654 mg/L 3compartmentss NA 95% Human Human +DTXSID7025394 Css NA 0.9078 mg/L PBTK NA 50% Human Human +DTXSID7025394 Css NA 4.737 mg/L PBTK NA 95% Human Human +DTXSID7025394 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025394 Fup 0.633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025394 Vd NA 0.6165 L/kg 1compartment NA NA Rat Human DTXSID7025394 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025394 TK.Half.Life NA 0.5991 hours 1compartment NA NA Rat Human -DTXSID7025394 Css NA 0.06292 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025394 Css NA 0.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025394 Css NA 0.05086 mg/L PBTK NA 50% Rat Human -DTXSID7025394 Css NA 0.1698 mg/L PBTK NA 95% Rat Human -DTXSID7025421 Clint NA 0.9051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025421 Fup NA 0.8238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025421 Vd NA 0.8941 L/kg 1compartment NA NA Human Human +DTXSID7025394 TK.Half.Life NA 2.147 hours 1compartment NA NA Rat Human +DTXSID7025394 Css NA 0.0714 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025394 Css NA 0.4244 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025394 Css NA 0.05525 mg/L PBTK NA 50% Rat Human +DTXSID7025394 Css NA 0.2571 mg/L PBTK NA 95% Rat Human +DTXSID7025421 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025421 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025421 Vd NA 0.586 L/kg 1compartment NA NA Human Human DTXSID7025421 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025421 TK.Half.Life NA 3.024 hours 1compartment NA NA Human Human -DTXSID7025421 Css NA 0.3852 mg/L 3compartmentss NA 50% Human Human -DTXSID7025421 Css NA 2.479 mg/L 3compartmentss NA 95% Human Human -DTXSID7025421 Css NA 0.3255 mg/L PBTK NA 50% Human Human -DTXSID7025421 Css NA 1.632 mg/L PBTK NA 95% Human Human -DTXSID7025421 Clint NA 0.9051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025421 Fup NA 0.8238 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025421 Vd NA 0.8929 L/kg 1compartment NA NA Rat Human +DTXSID7025421 TK.Half.Life NA 0.6678 hours 1compartment NA NA Human Human +DTXSID7025421 Css NA 0.04962 mg/L 3compartmentss NA 50% Human Human +DTXSID7025421 Css NA 0.3834 mg/L 3compartmentss NA 95% Human Human +DTXSID7025421 Css NA 0.03645 mg/L PBTK NA 50% Human Human +DTXSID7025421 Css NA 0.2548 mg/L PBTK NA 95% Human Human +DTXSID7025421 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025421 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025421 Vd NA 0.5821 L/kg 1compartment NA NA Rat Human DTXSID7025421 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025421 TK.Half.Life NA 1.427 hours 1compartment NA NA Rat Human -DTXSID7025421 Css NA 0.1405 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025421 Css NA 0.8893 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025421 Css NA 0.117 mg/L PBTK NA 50% Rat Human -DTXSID7025421 Css NA 0.5411 mg/L PBTK NA 95% Rat Human +DTXSID7025421 TK.Half.Life NA 0.3416 hours 1compartment NA NA Rat Human +DTXSID7025421 Css NA 0.006143 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025421 Css NA 0.03796 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025421 Css NA 0.004525 mg/L PBTK NA 50% Rat Human +DTXSID7025421 Css NA 0.02482 mg/L PBTK NA 95% Rat Human DTXSID7025423 Clint NA 2.046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7025423 Fup NA 0.9268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025423 Vd NA 1.398 L/kg 1compartment NA NA Human Human +DTXSID7025423 Vd NA 1.461 L/kg 1compartment NA NA Human Human DTXSID7025423 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025423 TK.Half.Life NA 2.626 hours 1compartment NA NA Human Human -DTXSID7025423 Css NA 0.1787 mg/L 3compartmentss NA 50% Human Human -DTXSID7025423 Css NA 0.8826 mg/L 3compartmentss NA 95% Human Human -DTXSID7025423 Css NA 0.1671 mg/L PBTK NA 50% Human Human -DTXSID7025423 Css NA 0.6975 mg/L PBTK NA 95% Human Human +DTXSID7025423 TK.Half.Life NA 2.745 hours 1compartment NA NA Human Human +DTXSID7025423 Css NA 0.1469 mg/L 3compartmentss NA 50% Human Human +DTXSID7025423 Css NA 0.7693 mg/L 3compartmentss NA 95% Human Human +DTXSID7025423 Css NA 0.1399 mg/L PBTK NA 50% Human Human +DTXSID7025423 Css NA 0.6051 mg/L PBTK NA 95% Human Human DTXSID7025423 Clint NA 2.046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7025423 Fup NA 0.9268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025423 Vd NA 1.432 L/kg 1compartment NA NA Rat Human +DTXSID7025423 Vd NA 1.492 L/kg 1compartment NA NA Rat Human DTXSID7025423 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025423 TK.Half.Life NA 1.402 hours 1compartment NA NA Rat Human -DTXSID7025423 Css NA 0.07484 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025423 Css NA 0.2969 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025423 Css NA 0.07076 mg/L PBTK NA 50% Rat Human -DTXSID7025423 Css NA 0.2127 mg/L PBTK NA 95% Rat Human -DTXSID7025425 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025425 Fup NA 0.4945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025425 Vd NA 0.5119 L/kg 1compartment NA NA Human Human -DTXSID7025425 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025425 TK.Half.Life NA 6.697 hours 1compartment NA NA Human Human -DTXSID7025425 Css NA 1.493 mg/L 3compartmentss NA 50% Human Human -DTXSID7025425 Css NA 7.715 mg/L 3compartmentss NA 95% Human Human -DTXSID7025425 Css NA 1.114 mg/L PBTK NA 50% Human Human -DTXSID7025425 Css NA 4.778 mg/L PBTK NA 95% Human Human -DTXSID7025425 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025425 Fup NA 0.4945 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025425 Vd NA 0.5365 L/kg 1compartment NA NA Rat Human -DTXSID7025425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025425 TK.Half.Life NA 2.392 hours 1compartment NA NA Rat Human -DTXSID7025425 Css NA 0.4066 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025425 Css NA 1.814 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025425 Css NA 0.2885 mg/L PBTK NA 50% Rat Human -DTXSID7025425 Css NA 1.063 mg/L PBTK NA 95% Rat Human +DTXSID7025423 TK.Half.Life NA 1.462 hours 1compartment NA NA Rat Human +DTXSID7025423 Css NA 0.004318 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025423 Css NA 0.0271 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025423 Css NA 0.004062 mg/L PBTK NA 50% Rat Human +DTXSID7025423 Css NA 0.02234 mg/L PBTK NA 95% Rat Human DTXSID7025427 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7025427 Fup NA 0.9035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7025427 Vd NA 0.6771 L/kg 1compartment NA NA Human Human DTXSID7025427 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7025427 TK.Half.Life NA 4.851 hours 1compartment NA NA Human Human -DTXSID7025427 Css NA 0.903 mg/L 3compartmentss NA 50% Human Human -DTXSID7025427 Css NA 3.442 mg/L 3compartmentss NA 95% Human Human -DTXSID7025427 Css NA 0.7369 mg/L PBTK NA 50% Human Human -DTXSID7025427 Css NA 2.369 mg/L PBTK NA 95% Human Human +DTXSID7025427 Css NA 0.7751 mg/L 3compartmentss NA 50% Human Human +DTXSID7025427 Css NA 2.95 mg/L 3compartmentss NA 95% Human Human +DTXSID7025427 Css NA 0.6304 mg/L PBTK NA 50% Human Human +DTXSID7025427 Css NA 2.017 mg/L PBTK NA 95% Human Human DTXSID7025427 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7025427 Fup NA 0.9035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7025427 Vd NA 0.7204 L/kg 1compartment NA NA Rat Human DTXSID7025427 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7025427 TK.Half.Life NA 1.758 hours 1compartment NA NA Rat Human -DTXSID7025427 Css NA 0.2334 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025427 Css NA 0.8285 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025427 Css NA 0.1851 mg/L PBTK NA 50% Rat Human -DTXSID7025427 Css NA 0.5218 mg/L PBTK NA 95% Rat Human -DTXSID7025429 Clint NA 35.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025429 Fup NA 0.0116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025429 Vd NA 1.719 L/kg 1compartment NA NA Human Human -DTXSID7025429 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7025429 TK.Half.Life NA 15.03 hours 1compartment NA NA Human Human -DTXSID7025429 Css NA 1.35 mg/L 3compartmentss NA 50% Human Human -DTXSID7025429 Css NA 12.01 mg/L 3compartmentss NA 95% Human Human -DTXSID7025429 Css NA 0.8487 mg/L PBTK NA 50% Human Human -DTXSID7025429 Css NA 7.269 mg/L PBTK NA 95% Human Human -DTXSID7025429 Clint NA 35.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025429 Fup NA 0.0116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025429 Vd NA 1.27 L/kg 1compartment NA NA Rat Human -DTXSID7025429 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025429 TK.Half.Life NA 5.382 hours 1compartment NA NA Rat Human -DTXSID7025429 Css NA 0.7698 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025429 Css NA 5.542 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025429 Css NA 0.4531 mg/L PBTK NA 50% Rat Human -DTXSID7025429 Css NA 3.154 mg/L PBTK NA 95% Rat Human -DTXSID7025479 Clint NA 4.505 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025479 Fup NA 0.2658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025479 Vd NA 2.241 L/kg 1compartment NA NA Human Human +DTXSID7025427 Css NA 0.01383 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025427 Css NA 0.07785 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025427 Css NA 0.01082 mg/L PBTK NA 50% Rat Human +DTXSID7025427 Css NA 0.05403 mg/L PBTK NA 95% Rat Human +DTXSID7025429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025429 Fup 0.00469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025429 Vd NA 1.121 L/kg 1compartment NA NA Human Human +DTXSID7025429 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7025429 TK.Half.Life NA 28.77 hours 1compartment NA NA Human Human +DTXSID7025429 Css NA 4.458 mg/L 3compartmentss NA 50% Human Human +DTXSID7025429 Css NA 41.04 mg/L 3compartmentss NA 95% Human Human +DTXSID7025429 Css NA 2.696 mg/L PBTK NA 50% Human Human +DTXSID7025429 Css NA 24.27 mg/L PBTK NA 95% Human Human +DTXSID7025429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025429 Fup 0.00469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025429 Vd NA 0.821 L/kg 1compartment NA NA Rat Human +DTXSID7025429 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7025429 TK.Half.Life NA 12.32 hours 1compartment NA NA Rat Human +DTXSID7025429 Css NA 0.5842 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025429 Css NA 4.49 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025429 Css NA 0.3415 mg/L PBTK NA 50% Rat Human +DTXSID7025429 Css NA 2.556 mg/L PBTK NA 95% Rat Human +DTXSID7025479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025479 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025479 Vd NA 1.651 L/kg 1compartment NA NA Human Human DTXSID7025479 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025479 TK.Half.Life NA 12.48 hours 1compartment NA NA Human Human -DTXSID7025479 Css NA 0.5824 mg/L 3compartmentss NA 50% Human Human -DTXSID7025479 Css NA 2.981 mg/L 3compartmentss NA 95% Human Human -DTXSID7025479 Css NA 0.4381 mg/L PBTK NA 50% Human Human -DTXSID7025479 Css NA 2.088 mg/L PBTK NA 95% Human Human -DTXSID7025479 Clint NA 4.505 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025479 Fup NA 0.2658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025479 Vd NA 1.748 L/kg 1compartment NA NA Rat Human +DTXSID7025479 TK.Half.Life NA 3.04 hours 1compartment NA NA Human Human +DTXSID7025479 Css NA 0.128 mg/L 3compartmentss NA 50% Human Human +DTXSID7025479 Css NA 0.9097 mg/L 3compartmentss NA 95% Human Human +DTXSID7025479 Css NA 0.09236 mg/L PBTK NA 50% Human Human +DTXSID7025479 Css NA 0.6099 mg/L PBTK NA 95% Human Human +DTXSID7025479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025479 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025479 Vd NA 1.305 L/kg 1compartment NA NA Rat Human DTXSID7025479 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025479 TK.Half.Life NA 3.763 hours 1compartment NA NA Rat Human -DTXSID7025479 Css NA 0.2917 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025479 Css NA 1.052 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025479 Css NA 0.2115 mg/L PBTK NA 50% Rat Human -DTXSID7025479 Css NA 0.6912 mg/L PBTK NA 95% Rat Human -DTXSID7025502 Clint NA 10.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025502 Fup NA 0.2646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025502 Vd NA 2.5 L/kg 1compartment NA NA Human Human +DTXSID7025479 TK.Half.Life NA 1.17 hours 1compartment NA NA Rat Human +DTXSID7025479 Css NA 0.01635 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025479 Css NA 0.08771 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025479 Css NA 0.01176 mg/L PBTK NA 50% Rat Human +DTXSID7025479 Css NA 0.05924 mg/L PBTK NA 95% Rat Human +DTXSID7025502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025502 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025502 Vd NA 2.414 L/kg 1compartment NA NA Human Human DTXSID7025502 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025502 TK.Half.Life NA 8.942 hours 1compartment NA NA Human Human -DTXSID7025502 Css NA 0.3486 mg/L 3compartmentss NA 50% Human Human -DTXSID7025502 Css NA 1.893 mg/L 3compartmentss NA 95% Human Human -DTXSID7025502 Css NA 0.256 mg/L PBTK NA 50% Human Human -DTXSID7025502 Css NA 1.319 mg/L PBTK NA 95% Human Human -DTXSID7025502 Clint NA 10.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025502 Fup NA 0.2646 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025502 Vd NA 1.917 L/kg 1compartment NA NA Rat Human +DTXSID7025502 TK.Half.Life NA 5.527 hours 1compartment NA NA Human Human +DTXSID7025502 Css NA 0.1806 mg/L 3compartmentss NA 50% Human Human +DTXSID7025502 Css NA 1.187 mg/L 3compartmentss NA 95% Human Human +DTXSID7025502 Css NA 0.1328 mg/L PBTK NA 50% Human Human +DTXSID7025502 Css NA 0.8247 mg/L PBTK NA 95% Human Human +DTXSID7025502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025502 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025502 Vd NA 1.848 L/kg 1compartment NA NA Rat Human DTXSID7025502 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025502 TK.Half.Life NA 2.42 hours 1compartment NA NA Rat Human -DTXSID7025502 Css NA 0.1827 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025502 Css NA 0.7705 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025502 Css NA 0.1306 mg/L PBTK NA 50% Rat Human -DTXSID7025502 Css NA 0.523 mg/L PBTK NA 95% Rat Human -DTXSID7025506 Clint NA 31.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025506 Fup NA 0.0111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025506 Vd NA 2.948 L/kg 1compartment NA NA Human Human +DTXSID7025502 TK.Half.Life NA 1.618 hours 1compartment NA NA Rat Human +DTXSID7025502 Css NA 0.02293 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025502 Css NA 0.1136 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025502 Css NA 0.01673 mg/L PBTK NA 50% Rat Human +DTXSID7025502 Css NA 0.08024 mg/L PBTK NA 95% Rat Human +DTXSID7025506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025506 Fup 0.0308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025506 Vd NA 4.357 L/kg 1compartment NA NA Human Human DTXSID7025506 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7025506 TK.Half.Life NA 29.19 hours 1compartment NA NA Human Human -DTXSID7025506 Css NA 1.424 mg/L 3compartmentss NA 50% Human Human -DTXSID7025506 Css NA 13.83 mg/L 3compartmentss NA 95% Human Human -DTXSID7025506 Css NA 0.9998 mg/L PBTK NA 50% Human Human -DTXSID7025506 Css NA 8.846 mg/L PBTK NA 95% Human Human -DTXSID7025506 Clint NA 31.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025506 Fup NA 0.0111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025506 Vd NA 2.227 L/kg 1compartment NA NA Rat Human -DTXSID7025506 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7025506 TK.Half.Life NA 11.49 hours 1compartment NA NA Rat Human -DTXSID7025506 Css NA 0.799 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025506 Css NA 6.429 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025506 Css NA 0.5329 mg/L PBTK NA 50% Rat Human -DTXSID7025506 Css NA 3.821 mg/L PBTK NA 95% Rat Human -DTXSID7025508 Clint NA 0.9707 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025508 Fup NA 0.1805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025508 Vd NA 0.3841 L/kg 1compartment NA NA Human Human +DTXSID7025506 TK.Half.Life NA 34.74 hours 1compartment NA NA Human Human +DTXSID7025506 Css NA 0.9308 mg/L 3compartmentss NA 50% Human Human +DTXSID7025506 Css NA 7.763 mg/L 3compartmentss NA 95% Human Human +DTXSID7025506 Css NA 0.7504 mg/L PBTK NA 50% Human Human +DTXSID7025506 Css NA 5.47 mg/L PBTK NA 95% Human Human +DTXSID7025506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025506 Fup 0.0308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025506 Vd NA 3.342 L/kg 1compartment NA NA Rat Human +DTXSID7025506 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7025506 TK.Half.Life NA 10.67 hours 1compartment NA NA Rat Human +DTXSID7025506 Css NA 0.1184 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025506 Css NA 0.8229 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025506 Css NA 0.09481 mg/L PBTK NA 50% Rat Human +DTXSID7025506 Css NA 0.588 mg/L PBTK NA 95% Rat Human +DTXSID7025508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025508 Fup 0.0993 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025508 Vd NA 0.364 L/kg 1compartment NA NA Human Human DTXSID7025508 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025508 TK.Half.Life NA 5.407 hours 1compartment NA NA Human Human -DTXSID7025508 Css NA 1.716 mg/L 3compartmentss NA 50% Human Human -DTXSID7025508 Css NA 7.033 mg/L 3compartmentss NA 95% Human Human -DTXSID7025508 Css NA 1.138 mg/L PBTK NA 50% Human Human -DTXSID7025508 Css NA 4.322 mg/L PBTK NA 95% Human Human -DTXSID7025508 Clint NA 0.9707 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025508 Fup NA 0.1805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025508 Vd NA 0.3715 L/kg 1compartment NA NA Rat Human +DTXSID7025508 TK.Half.Life NA 0.9425 hours 1compartment NA NA Human Human +DTXSID7025508 Css NA 0.2834 mg/L 3compartmentss NA 50% Human Human +DTXSID7025508 Css NA 2.399 mg/L 3compartmentss NA 95% Human Human +DTXSID7025508 Css NA 0.1786 mg/L PBTK NA 50% Human Human +DTXSID7025508 Css NA 1.439 mg/L PBTK NA 95% Human Human +DTXSID7025508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025508 Fup 0.0993 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025508 Vd NA 0.3395 L/kg 1compartment NA NA Rat Human DTXSID7025508 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025508 TK.Half.Life NA 2.573 hours 1compartment NA NA Rat Human -DTXSID7025508 Css NA 0.6966 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025508 Css NA 2.241 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025508 Css NA 0.4373 mg/L PBTK NA 50% Rat Human -DTXSID7025508 Css NA 1.284 mg/L PBTK NA 95% Rat Human -DTXSID7025558 Clint NA 17.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025558 Fup NA 0.0764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025558 Vd NA 1.898 L/kg 1compartment NA NA Human Human -DTXSID7025558 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025558 TK.Half.Life NA 8.73 hours 1compartment NA NA Human Human -DTXSID7025558 Css NA 0.5885 mg/L 3compartmentss NA 50% Human Human -DTXSID7025558 Css NA 4.11 mg/L 3compartmentss NA 95% Human Human -DTXSID7025558 Css NA 0.3901 mg/L PBTK NA 50% Human Human -DTXSID7025558 Css NA 2.596 mg/L PBTK NA 95% Human Human -DTXSID7025558 Clint NA 17.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025558 Fup NA 0.0764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025558 Vd NA 1.432 L/kg 1compartment NA NA Rat Human +DTXSID7025508 TK.Half.Life NA 0.5216 hours 1compartment NA NA Rat Human +DTXSID7025508 Css NA 0.0372 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025508 Css NA 0.2325 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025508 Css NA 0.02271 mg/L PBTK NA 50% Rat Human +DTXSID7025508 Css NA 0.1388 mg/L PBTK NA 95% Rat Human +DTXSID7025558 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025558 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025558 Vd NA 0.9287 L/kg 1compartment NA NA Human Human +DTXSID7025558 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7025558 TK.Half.Life NA 13.85 hours 1compartment NA NA Human Human +DTXSID7025558 Css NA 2.487 mg/L 3compartmentss NA 50% Human Human +DTXSID7025558 Css NA 19.72 mg/L 3compartmentss NA 95% Human Human +DTXSID7025558 Css NA 1.539 mg/L PBTK NA 50% Human Human +DTXSID7025558 Css NA 11.61 mg/L PBTK NA 95% Human Human +DTXSID7025558 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025558 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025558 Vd NA 0.7066 L/kg 1compartment NA NA Rat Human DTXSID7025558 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025558 TK.Half.Life NA 2.979 hours 1compartment NA NA Rat Human -DTXSID7025558 Css NA 0.3238 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025558 Css NA 1.728 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025558 Css NA 0.2044 mg/L PBTK NA 50% Rat Human -DTXSID7025558 Css NA 1.038 mg/L PBTK NA 95% Rat Human -DTXSID7025633 Clint NA 3.523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025633 Fup NA 0.4261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025633 Vd NA 1.176 L/kg 1compartment NA NA Human Human +DTXSID7025558 TK.Half.Life NA 6.091 hours 1compartment NA NA Rat Human +DTXSID7025558 Css NA 0.312 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025558 Css NA 1.927 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025558 Css NA 0.1853 mg/L PBTK NA 50% Rat Human +DTXSID7025558 Css NA 1.104 mg/L PBTK NA 95% Rat Human +DTXSID7025633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025633 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025633 Vd NA 0.8701 L/kg 1compartment NA NA Human Human DTXSID7025633 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025633 TK.Half.Life NA 3.396 hours 1compartment NA NA Human Human -DTXSID7025633 Css NA 0.2613 mg/L 3compartmentss NA 50% Human Human -DTXSID7025633 Css NA 1.584 mg/L 3compartmentss NA 95% Human Human -DTXSID7025633 Css NA 0.2088 mg/L PBTK NA 50% Human Human -DTXSID7025633 Css NA 1.093 mg/L PBTK NA 95% Human Human -DTXSID7025633 Clint NA 3.523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025633 Fup NA 0.4261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025633 Vd NA 1.02 L/kg 1compartment NA NA Rat Human +DTXSID7025633 TK.Half.Life NA 1.2 hours 1compartment NA NA Human Human +DTXSID7025633 Css NA 0.07598 mg/L 3compartmentss NA 50% Human Human +DTXSID7025633 Css NA 0.5524 mg/L 3compartmentss NA 95% Human Human +DTXSID7025633 Css NA 0.0547 mg/L PBTK NA 50% Human Human +DTXSID7025633 Css NA 0.3686 mg/L PBTK NA 95% Human Human +DTXSID7025633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025633 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025633 Vd NA 0.7583 L/kg 1compartment NA NA Rat Human DTXSID7025633 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025633 TK.Half.Life NA 1.541 hours 1compartment NA NA Rat Human -DTXSID7025633 Css NA 0.1248 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025633 Css NA 0.6112 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025633 Css NA 0.09637 mg/L PBTK NA 50% Rat Human -DTXSID7025633 Css NA 0.3844 mg/L PBTK NA 95% Rat Human -DTXSID7025635 Clint NA 16.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025635 Fup NA 0.4776 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025635 Vd NA 1.768 L/kg 1compartment NA NA Human Human +DTXSID7025633 TK.Half.Life NA 0.5514 hours 1compartment NA NA Rat Human +DTXSID7025633 Css NA 0.009686 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025633 Css NA 0.05276 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025633 Css NA 0.006964 mg/L PBTK NA 50% Rat Human +DTXSID7025633 Css NA 0.03553 mg/L PBTK NA 95% Rat Human +DTXSID7025635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025635 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025635 Vd NA 1.324 L/kg 1compartment NA NA Human Human DTXSID7025635 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025635 TK.Half.Life NA 2.153 hours 1compartment NA NA Human Human -DTXSID7025635 Css NA 0.06758 mg/L 3compartmentss NA 50% Human Human -DTXSID7025635 Css NA 0.5176 mg/L 3compartmentss NA 95% Human Human -DTXSID7025635 Css NA 0.0556 mg/L PBTK NA 50% Human Human -DTXSID7025635 Css NA 0.381 mg/L PBTK NA 95% Human Human -DTXSID7025635 Clint NA 16.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025635 Fup NA 0.4776 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025635 Vd NA 1.45 L/kg 1compartment NA NA Rat Human +DTXSID7025635 TK.Half.Life NA 1.921 hours 1compartment NA NA Human Human +DTXSID7025635 Css NA 0.08527 mg/L 3compartmentss NA 50% Human Human +DTXSID7025635 Css NA 0.6053 mg/L 3compartmentss NA 95% Human Human +DTXSID7025635 Css NA 0.06261 mg/L PBTK NA 50% Human Human +DTXSID7025635 Css NA 0.4206 mg/L PBTK NA 95% Human Human +DTXSID7025635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025635 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025635 Vd NA 1.078 L/kg 1compartment NA NA Rat Human DTXSID7025635 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025635 TK.Half.Life NA 0.8279 hours 1compartment NA NA Rat Human -DTXSID7025635 Css NA 0.0352 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025635 Css NA 0.2182 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025635 Css NA 0.02827 mg/L PBTK NA 50% Rat Human -DTXSID7025635 Css NA 0.1493 mg/L PBTK NA 95% Rat Human -DTXSID7025637 Clint NA 0.9165 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025637 Fup NA 0.1216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025637 Vd NA 0.4061 L/kg 1compartment NA NA Human Human +DTXSID7025635 TK.Half.Life NA 0.7894 hours 1compartment NA NA Rat Human +DTXSID7025635 Css NA 0.01052 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025635 Css NA 0.05819 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025635 Css NA 0.007788 mg/L PBTK NA 50% Rat Human +DTXSID7025635 Css NA 0.03878 mg/L PBTK NA 95% Rat Human +DTXSID7025637 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025637 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025637 Vd NA 0.4261 L/kg 1compartment NA NA Human Human DTXSID7025637 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025637 TK.Half.Life NA 8.707 hours 1compartment NA NA Human Human -DTXSID7025637 Css NA 3.158 mg/L 3compartmentss NA 50% Human Human -DTXSID7025637 Css NA 16.23 mg/L 3compartmentss NA 95% Human Human -DTXSID7025637 Css NA 2.061 mg/L PBTK NA 50% Human Human -DTXSID7025637 Css NA 9.791 mg/L PBTK NA 95% Human Human -DTXSID7025637 Clint NA 0.9165 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025637 Fup NA 0.1216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025637 Vd NA 0.4018 L/kg 1compartment NA NA Rat Human +DTXSID7025637 TK.Half.Life NA 0.8961 hours 1compartment NA NA Human Human +DTXSID7025637 Css NA 0.194 mg/L 3compartmentss NA 50% Human Human +DTXSID7025637 Css NA 1.675 mg/L 3compartmentss NA 95% Human Human +DTXSID7025637 Css NA 0.128 mg/L PBTK NA 50% Human Human +DTXSID7025637 Css NA 1.046 mg/L PBTK NA 95% Human Human +DTXSID7025637 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025637 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025637 Vd NA 0.4219 L/kg 1compartment NA NA Rat Human DTXSID7025637 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025637 TK.Half.Life NA 4.221 hours 1compartment NA NA Rat Human -DTXSID7025637 Css NA 1.283 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025637 Css NA 5.521 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025637 Css NA 0.7831 mg/L PBTK NA 50% Rat Human -DTXSID7025637 Css NA 3.089 mg/L PBTK NA 95% Rat Human -DTXSID7025639 Clint NA 1.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025639 Fup NA 0.1381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025639 Vd NA 0.4169 L/kg 1compartment NA NA Human Human +DTXSID7025637 TK.Half.Life NA 0.5154 hours 1compartment NA NA Rat Human +DTXSID7025637 Css NA 0.02553 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025637 Css NA 0.1593 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025637 Css NA 0.01636 mg/L PBTK NA 50% Rat Human +DTXSID7025637 Css NA 0.09585 mg/L PBTK NA 95% Rat Human +DTXSID7025639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025639 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025639 Vd NA 0.5345 L/kg 1compartment NA NA Human Human DTXSID7025639 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025639 TK.Half.Life NA 6.424 hours 1compartment NA NA Human Human -DTXSID7025639 Css NA 2.187 mg/L 3compartmentss NA 50% Human Human -DTXSID7025639 Css NA 12.08 mg/L 3compartmentss NA 95% Human Human -DTXSID7025639 Css NA 1.434 mg/L PBTK NA 50% Human Human -DTXSID7025639 Css NA 7.219 mg/L PBTK NA 95% Human Human -DTXSID7025639 Clint NA 1.277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025639 Fup NA 0.1381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025639 Vd NA 0.4145 L/kg 1compartment NA NA Rat Human +DTXSID7025639 TK.Half.Life NA 1.714 hours 1compartment NA NA Human Human +DTXSID7025639 Css NA 0.307 mg/L 3compartmentss NA 50% Human Human +DTXSID7025639 Css NA 1.755 mg/L 3compartmentss NA 95% Human Human +DTXSID7025639 Css NA 0.2178 mg/L PBTK NA 50% Human Human +DTXSID7025639 Css NA 1.159 mg/L PBTK NA 95% Human Human +DTXSID7025639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025639 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025639 Vd NA 0.5339 L/kg 1compartment NA NA Rat Human DTXSID7025639 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025639 TK.Half.Life NA 3.301 hours 1compartment NA NA Rat Human -DTXSID7025639 Css NA 0.9482 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025639 Css NA 4.199 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025639 Css NA 0.5848 mg/L PBTK NA 50% Rat Human -DTXSID7025639 Css NA 2.364 mg/L PBTK NA 95% Rat Human -DTXSID7025689 Clint NA 0.9083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025689 Fup NA 0.0807 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025689 Vd NA 2.444 L/kg 1compartment NA NA Human Human -DTXSID7025689 Days.Css NA 35 Days PBTK NA NA Human Human -DTXSID7025689 TK.Half.Life NA 173.8 hours 1compartment NA NA Human Human -DTXSID7025689 Css NA 9.619 mg/L 3compartmentss NA 50% Human Human -DTXSID7025689 Css NA 37.16 mg/L 3compartmentss NA 95% Human Human -DTXSID7025689 Css NA 6.581 mg/L PBTK NA 50% Human Human -DTXSID7025689 Css NA 23.79 mg/L PBTK NA 95% Human Human -DTXSID7025689 Clint NA 0.9083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025689 Fup NA 0.0807 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025689 Vd NA 1.836 L/kg 1compartment NA NA Rat Human -DTXSID7025689 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID7025689 TK.Half.Life NA 34.57 hours 1compartment NA NA Rat Human -DTXSID7025689 Css NA 4.125 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025689 Css NA 12.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025689 Css NA 2.675 mg/L PBTK NA 50% Rat Human -DTXSID7025689 Css NA 7.148 mg/L PBTK NA 95% Rat Human -DTXSID7025716 Clint NA 4.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025716 Fup NA 0.7512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025716 Vd NA 0.8248 L/kg 1compartment NA NA Human Human -DTXSID7025716 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025716 TK.Half.Life NA 1.259 hours 1compartment NA NA Human Human -DTXSID7025716 Css NA 0.1339 mg/L 3compartmentss NA 50% Human Human -DTXSID7025716 Css NA 1.06 mg/L 3compartmentss NA 95% Human Human -DTXSID7025716 Css NA 0.1132 mg/L PBTK NA 50% Human Human -DTXSID7025716 Css NA 0.7188 mg/L PBTK NA 95% Human Human -DTXSID7025716 Clint NA 4.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025716 Fup NA 0.7512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025716 Vd NA 0.8443 L/kg 1compartment NA NA Rat Human +DTXSID7025639 TK.Half.Life NA 1.005 hours 1compartment NA NA Rat Human +DTXSID7025639 Css NA 0.03574 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025639 Css NA 0.1586 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025639 Css NA 0.02522 mg/L PBTK NA 50% Rat Human +DTXSID7025639 Css NA 0.1002 mg/L PBTK NA 95% Rat Human +DTXSID7025689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025689 Fup 0.0147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025689 Vd NA 1.84 L/kg 1compartment NA NA Human Human +DTXSID7025689 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7025689 TK.Half.Life NA 22.14 hours 1compartment NA NA Human Human +DTXSID7025689 Css NA 1.832 mg/L 3compartmentss NA 50% Human Human +DTXSID7025689 Css NA 15.9 mg/L 3compartmentss NA 95% Human Human +DTXSID7025689 Css NA 1.152 mg/L PBTK NA 50% Human Human +DTXSID7025689 Css NA 9.458 mg/L PBTK NA 95% Human Human +DTXSID7025689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025689 Fup 0.0147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025689 Vd NA 1.363 L/kg 1compartment NA NA Rat Human +DTXSID7025689 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7025689 TK.Half.Life NA 7.576 hours 1compartment NA NA Rat Human +DTXSID7025689 Css NA 0.2404 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025689 Css NA 1.68 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025689 Css NA 0.1485 mg/L PBTK NA 50% Rat Human +DTXSID7025689 Css NA 1.004 mg/L PBTK NA 95% Rat Human +DTXSID7025716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025716 Fup 0.288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025716 Vd NA 0.4748 L/kg 1compartment NA NA Human Human +DTXSID7025716 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7025716 TK.Half.Life NA 10.66 hours 1compartment NA NA Human Human +DTXSID7025716 Css NA 2.556 mg/L 3compartmentss NA 50% Human Human +DTXSID7025716 Css NA 9.914 mg/L 3compartmentss NA 95% Human Human +DTXSID7025716 Css NA 1.797 mg/L PBTK NA 50% Human Human +DTXSID7025716 Css NA 6.209 mg/L PBTK NA 95% Human Human +DTXSID7025716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025716 Fup 0.288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025716 Vd NA 0.4827 L/kg 1compartment NA NA Rat Human DTXSID7025716 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025716 TK.Half.Life NA 0.6932 hours 1compartment NA NA Rat Human -DTXSID7025716 Css NA 0.06041 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025716 Css NA 0.4557 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025716 Css NA 0.05074 mg/L PBTK NA 50% Rat Human -DTXSID7025716 Css NA 0.2781 mg/L PBTK NA 95% Rat Human -DTXSID7025764 Clint NA 9.781 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025764 Fup NA 0.4184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025764 Vd NA 0.8741 L/kg 1compartment NA NA Human Human +DTXSID7025716 TK.Half.Life NA 3.695 hours 1compartment NA NA Rat Human +DTXSID7025716 Css NA 0.1621 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025716 Css NA 0.5424 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025716 Css NA 0.1125 mg/L PBTK NA 50% Rat Human +DTXSID7025716 Css NA 0.3273 mg/L PBTK NA 95% Rat Human +DTXSID7025764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025764 Fup 0.346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025764 Vd NA 0.7838 L/kg 1compartment NA NA Human Human DTXSID7025764 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025764 TK.Half.Life NA 1.341 hours 1compartment NA NA Human Human -DTXSID7025764 Css NA 0.1042 mg/L 3compartmentss NA 50% Human Human -DTXSID7025764 Css NA 0.7627 mg/L 3compartmentss NA 95% Human Human -DTXSID7025764 Css NA 0.0802 mg/L PBTK NA 50% Human Human -DTXSID7025764 Css NA 0.5245 mg/L PBTK NA 95% Human Human -DTXSID7025764 Clint NA 9.781 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025764 Fup NA 0.4184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025764 Vd NA 0.8019 L/kg 1compartment NA NA Rat Human +DTXSID7025764 TK.Half.Life NA 0.9442 hours 1compartment NA NA Human Human +DTXSID7025764 Css NA 0.05696 mg/L 3compartmentss NA 50% Human Human +DTXSID7025764 Css NA 0.4268 mg/L 3compartmentss NA 95% Human Human +DTXSID7025764 Css NA 0.04207 mg/L PBTK NA 50% Human Human +DTXSID7025764 Css NA 0.2925 mg/L PBTK NA 95% Human Human +DTXSID7025764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025764 Fup 0.346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025764 Vd NA 0.7179 L/kg 1compartment NA NA Rat Human DTXSID7025764 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025764 TK.Half.Life NA 0.6639 hours 1compartment NA NA Rat Human -DTXSID7025764 Css NA 0.05436 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025764 Css NA 0.2966 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025764 Css NA 0.04056 mg/L PBTK NA 50% Rat Human -DTXSID7025764 Css NA 0.1948 mg/L PBTK NA 95% Rat Human -DTXSID7025768 Clint NA 0.9466 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025768 Fup NA 0.5351 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025768 Vd NA 1.124 L/kg 1compartment NA NA Human Human -DTXSID7025768 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025768 TK.Half.Life NA 5.884 hours 1compartment NA NA Human Human -DTXSID7025768 Css NA 0.525 mg/L 3compartmentss NA 50% Human Human -DTXSID7025768 Css NA 3.189 mg/L 3compartmentss NA 95% Human Human -DTXSID7025768 Css NA 0.4388 mg/L PBTK NA 50% Human Human -DTXSID7025768 Css NA 2.132 mg/L PBTK NA 95% Human Human -DTXSID7025768 Clint NA 0.9466 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025768 Fup NA 0.5351 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025768 Vd NA 1.01 L/kg 1compartment NA NA Rat Human -DTXSID7025768 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025768 TK.Half.Life NA 2.433 hours 1compartment NA NA Rat Human -DTXSID7025768 Css NA 0.2046 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025768 Css NA 1.146 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025768 Css NA 0.1654 mg/L PBTK NA 50% Rat Human -DTXSID7025768 Css NA 0.691 mg/L PBTK NA 95% Rat Human +DTXSID7025764 TK.Half.Life NA 0.4492 hours 1compartment NA NA Rat Human +DTXSID7025764 Css NA 0.007101 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025764 Css NA 0.04167 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025764 Css NA 0.005253 mg/L PBTK NA 50% Rat Human +DTXSID7025764 Css NA 0.02821 mg/L PBTK NA 95% Rat Human DTXSID7025895 Clint 15.59 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7025895 Fup 0.1434 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID7025895 Vd NA 1.673 L/kg 1compartment NA NA Human Human +DTXSID7025895 Vd NA 1.332 L/kg 1compartment NA NA Human Human DTXSID7025895 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025895 TK.Half.Life NA 4.824 hours 1compartment NA NA Human Human -DTXSID7025895 Css NA 0.3052 mg/L 3compartmentss NA 50% Human Human -DTXSID7025895 Css NA 2.213 mg/L 3compartmentss NA 95% Human Human -DTXSID7025895 Css NA 0.2099 mg/L PBTK NA 50% Human Human -DTXSID7025895 Css NA 1.408 mg/L PBTK NA 95% Human Human +DTXSID7025895 TK.Half.Life NA 3.542 hours 1compartment NA NA Human Human +DTXSID7025895 Css NA 0.2648 mg/L 3compartmentss NA 50% Human Human +DTXSID7025895 Css NA 2.045 mg/L 3compartmentss NA 95% Human Human +DTXSID7025895 Css NA 0.1795 mg/L PBTK NA 50% Human Human +DTXSID7025895 Css NA 1.292 mg/L PBTK NA 95% Human Human DTXSID7025895 Clint 15.59 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7025895 Fup 0.1434 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID7025895 Vd NA 1.289 L/kg 1compartment NA NA Rat Human +DTXSID7025895 Vd NA 1.043 L/kg 1compartment NA NA Rat Human DTXSID7025895 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025895 TK.Half.Life NA 1.801 hours 1compartment NA NA Rat Human -DTXSID7025895 Css NA 0.1691 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025895 Css NA 0.9258 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025895 Css NA 0.1101 mg/L PBTK NA 50% Rat Human -DTXSID7025895 Css NA 0.5659 mg/L PBTK NA 95% Rat Human -DTXSID7025924 Clint NA 96.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025924 Fup NA 0.8418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025924 Vd NA 1.27 L/kg 1compartment NA NA Human Human +DTXSID7025895 TK.Half.Life NA 1.453 hours 1compartment NA NA Rat Human +DTXSID7025895 Css NA 0.034 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025895 Css NA 0.195 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025895 Css NA 0.02274 mg/L PBTK NA 50% Rat Human +DTXSID7025895 Css NA 0.1226 mg/L PBTK NA 95% Rat Human +DTXSID7025924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025924 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025924 Vd NA 0.729 L/kg 1compartment NA NA Human Human DTXSID7025924 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025924 TK.Half.Life NA 0.7428 hours 1compartment NA NA Human Human -DTXSID7025924 Css NA 0.006015 mg/L 3compartmentss NA 50% Human Human -DTXSID7025924 Css NA 0.06476 mg/L 3compartmentss NA 95% Human Human -DTXSID7025924 Css NA 0.00534 mg/L PBTK NA 50% Human Human -DTXSID7025924 Css NA 0.0487 mg/L PBTK NA 95% Human Human -DTXSID7025924 Clint NA 96.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025924 Fup NA 0.8418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025924 Vd NA 1.182 L/kg 1compartment NA NA Rat Human +DTXSID7025924 TK.Half.Life NA 0.9089 hours 1compartment NA NA Human Human +DTXSID7025924 Css NA 0.06109 mg/L 3compartmentss NA 50% Human Human +DTXSID7025924 Css NA 0.4723 mg/L 3compartmentss NA 95% Human Human +DTXSID7025924 Css NA 0.04468 mg/L PBTK NA 50% Human Human +DTXSID7025924 Css NA 0.3145 mg/L PBTK NA 95% Human Human +DTXSID7025924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025924 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025924 Vd NA 0.6728 L/kg 1compartment NA NA Rat Human DTXSID7025924 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025924 TK.Half.Life NA 0.307 hours 1compartment NA NA Rat Human -DTXSID7025924 Css NA 0.003077 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025924 Css NA 0.03013 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025924 Css NA 0.002734 mg/L PBTK NA 50% Rat Human -DTXSID7025924 Css NA 0.02225 mg/L PBTK NA 95% Rat Human -DTXSID7025926 Clint NA 72.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025926 Fup NA 0.4201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025926 Vd NA 1.412 L/kg 1compartment NA NA Human Human +DTXSID7025924 TK.Half.Life NA 0.4393 hours 1compartment NA NA Rat Human +DTXSID7025924 Css NA 0.007733 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025924 Css NA 0.04585 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025924 Css NA 0.005604 mg/L PBTK NA 50% Rat Human +DTXSID7025924 Css NA 0.03064 mg/L PBTK NA 95% Rat Human +DTXSID7025926 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025926 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025926 Vd NA 1.055 L/kg 1compartment NA NA Human Human DTXSID7025926 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025926 TK.Half.Life NA 1.135 hours 1compartment NA NA Human Human -DTXSID7025926 Css NA 0.01625 mg/L 3compartmentss NA 50% Human Human -DTXSID7025926 Css NA 0.1308 mg/L 3compartmentss NA 95% Human Human -DTXSID7025926 Css NA 0.01294 mg/L PBTK NA 50% Human Human -DTXSID7025926 Css NA 0.09264 mg/L PBTK NA 95% Human Human -DTXSID7025926 Clint NA 72.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025926 Fup NA 0.4201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025926 Vd NA 1.185 L/kg 1compartment NA NA Rat Human +DTXSID7025926 TK.Half.Life NA 1.691 hours 1compartment NA NA Human Human +DTXSID7025926 Css NA 0.1007 mg/L 3compartmentss NA 50% Human Human +DTXSID7025926 Css NA 0.723 mg/L 3compartmentss NA 95% Human Human +DTXSID7025926 Css NA 0.07184 mg/L PBTK NA 50% Human Human +DTXSID7025926 Css NA 0.4774 mg/L PBTK NA 95% Human Human +DTXSID7025926 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025926 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025926 Vd NA 0.8701 L/kg 1compartment NA NA Rat Human DTXSID7025926 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025926 TK.Half.Life NA 0.4354 hours 1compartment NA NA Rat Human -DTXSID7025926 Css NA 0.008651 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025926 Css NA 0.05558 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025926 Css NA 0.006724 mg/L PBTK NA 50% Rat Human -DTXSID7025926 Css NA 0.03843 mg/L PBTK NA 95% Rat Human -DTXSID7025972 Clint NA 6.833 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025972 Fup NA 0.1436 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7025972 Vd NA 0.7076 L/kg 1compartment NA NA Human Human +DTXSID7025926 TK.Half.Life NA 0.7354 hours 1compartment NA NA Rat Human +DTXSID7025926 Css NA 0.01282 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025926 Css NA 0.06849 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025926 Css NA 0.009001 mg/L PBTK NA 50% Rat Human +DTXSID7025926 Css NA 0.04609 mg/L PBTK NA 95% Rat Human +DTXSID7025972 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025972 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7025972 Vd NA 0.9025 L/kg 1compartment NA NA Human Human DTXSID7025972 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7025972 TK.Half.Life NA 3.112 hours 1compartment NA NA Human Human -DTXSID7025972 Css NA 0.5496 mg/L 3compartmentss NA 50% Human Human -DTXSID7025972 Css NA 3.768 mg/L 3compartmentss NA 95% Human Human -DTXSID7025972 Css NA 0.3613 mg/L PBTK NA 50% Human Human -DTXSID7025972 Css NA 2.292 mg/L PBTK NA 95% Human Human -DTXSID7025972 Clint NA 6.833 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025972 Fup NA 0.1436 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7025972 Vd NA 0.5987 L/kg 1compartment NA NA Rat Human +DTXSID7025972 TK.Half.Life NA 1.383 hours 1compartment NA NA Human Human +DTXSID7025972 Css NA 0.09278 mg/L 3compartmentss NA 50% Human Human +DTXSID7025972 Css NA 0.656 mg/L 3compartmentss NA 95% Human Human +DTXSID7025972 Css NA 0.06519 mg/L PBTK NA 50% Human Human +DTXSID7025972 Css NA 0.4329 mg/L PBTK NA 95% Human Human +DTXSID7025972 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025972 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7025972 Vd NA 0.7669 L/kg 1compartment NA NA Rat Human DTXSID7025972 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7025972 TK.Half.Life NA 1.537 hours 1compartment NA NA Rat Human -DTXSID7025972 Css NA 0.2947 mg/L 3compartmentss NA 50% Rat Human -DTXSID7025972 Css NA 1.539 mg/L 3compartmentss NA 95% Rat Human -DTXSID7025972 Css NA 0.1828 mg/L PBTK NA 50% Rat Human -DTXSID7025972 Css NA 0.8781 mg/L PBTK NA 95% Rat Human -DTXSID7026025 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026025 Fup NA 0.3317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026025 Vd NA 0.786 L/kg 1compartment NA NA Human Human -DTXSID7026025 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7026025 TK.Half.Life NA 15.34 hours 1compartment NA NA Human Human -DTXSID7026025 Css NA 1.968 mg/L 3compartmentss NA 50% Human Human -DTXSID7026025 Css NA 8.505 mg/L 3compartmentss NA 95% Human Human -DTXSID7026025 Css NA 1.618 mg/L PBTK NA 50% Human Human -DTXSID7026025 Css NA 5.687 mg/L PBTK NA 95% Human Human -DTXSID7026025 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026025 Fup NA 0.3317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026025 Vd NA 0.7848 L/kg 1compartment NA NA Rat Human -DTXSID7026025 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026025 TK.Half.Life NA 5.216 hours 1compartment NA NA Rat Human -DTXSID7026025 Css NA 0.531 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026025 Css NA 2.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026025 Css NA 0.4208 mg/L PBTK NA 50% Rat Human -DTXSID7026025 Css NA 1.261 mg/L PBTK NA 95% Rat Human +DTXSID7025972 TK.Half.Life NA 0.6261 hours 1compartment NA NA Rat Human +DTXSID7025972 Css NA 0.01193 mg/L 3compartmentss NA 50% Rat Human +DTXSID7025972 Css NA 0.06512 mg/L 3compartmentss NA 95% Rat Human +DTXSID7025972 Css NA 0.00832 mg/L PBTK NA 50% Rat Human +DTXSID7025972 Css NA 0.04261 mg/L PBTK NA 95% Rat Human DTXSID7026029 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7026029 Fup 0.062 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7026029 Vd NA 0.2295 L/kg 1compartment NA NA Human Human -DTXSID7026029 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7026029 TK.Half.Life NA 23.94 hours 1compartment NA NA Human Human -DTXSID7026029 Css NA 13.4 mg/L 3compartmentss NA 50% Human Human -DTXSID7026029 Css NA 55.62 mg/L 3compartmentss NA 95% Human Human -DTXSID7026029 Css NA 8.161 mg/L PBTK NA 50% Human Human -DTXSID7026029 Css NA 32.51 mg/L PBTK NA 95% Human Human +DTXSID7026029 Vd NA 0.1957 L/kg 1compartment NA NA Human Human +DTXSID7026029 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7026029 TK.Half.Life NA 20.42 hours 1compartment NA NA Human Human +DTXSID7026029 Css NA 13.37 mg/L 3compartmentss NA 50% Human Human +DTXSID7026029 Css NA 53.1 mg/L 3compartmentss NA 95% Human Human +DTXSID7026029 Css NA 7.968 mg/L PBTK NA 50% Human Human +DTXSID7026029 Css NA 31.06 mg/L PBTK NA 95% Human Human DTXSID7026029 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7026029 Fup 0.062 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7026029 Vd NA 0.2287 L/kg 1compartment NA NA Rat Human +DTXSID7026029 Vd NA 0.1963 L/kg 1compartment NA NA Rat Human DTXSID7026029 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026029 TK.Half.Life NA 8.134 hours 1compartment NA NA Rat Human -DTXSID7026029 Css NA 3.858 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026029 Css NA 12.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026029 Css NA 2.184 mg/L PBTK NA 50% Rat Human -DTXSID7026029 Css NA 7.016 mg/L PBTK NA 95% Rat Human +DTXSID7026029 TK.Half.Life NA 6.981 hours 1compartment NA NA Rat Human +DTXSID7026029 Css NA 0.8804 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026029 Css NA 2.929 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026029 Css NA 0.5078 mg/L PBTK NA 50% Rat Human +DTXSID7026029 Css NA 1.654 mg/L PBTK NA 95% Rat Human DTXSID7026102 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7026102 Fup NA 0.0608 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026102 Vd NA 1.119 L/kg 1compartment NA NA Human Human -DTXSID7026102 Days.Css NA 30 Days PBTK NA NA Human Human -DTXSID7026102 TK.Half.Life NA 143.2 hours 1compartment NA NA Human Human -DTXSID7026102 Css NA 19.79 mg/L 3compartmentss NA 50% Human Human -DTXSID7026102 Css NA 83.56 mg/L 3compartmentss NA 95% Human Human -DTXSID7026102 Css NA 12.5 mg/L PBTK NA 50% Human Human -DTXSID7026102 Css NA 49.61 mg/L PBTK NA 95% Human Human +DTXSID7026102 Vd NA 1.755 L/kg 1compartment NA NA Human Human +DTXSID7026102 Days.Css NA 68 Days PBTK NA NA Human Human +DTXSID7026102 TK.Half.Life NA 301.1 hours 1compartment NA NA Human Human +DTXSID7026102 Css NA 24.16 mg/L 3compartmentss NA 50% Human Human +DTXSID7026102 Css NA 93.05 mg/L 3compartmentss NA 95% Human Human +DTXSID7026102 Css NA 15.78 mg/L PBTK NA 50% Human Human +DTXSID7026102 Css NA 56.86 mg/L PBTK NA 95% Human Human DTXSID7026102 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7026102 Fup NA 0.0608 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026102 Vd NA 0.8549 L/kg 1compartment NA NA Rat Human -DTXSID7026102 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID7026102 TK.Half.Life NA 32.51 hours 1compartment NA NA Rat Human -DTXSID7026102 Css NA 5.533 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026102 Css NA 20.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026102 Css NA 3.29 mg/L PBTK NA 50% Rat Human -DTXSID7026102 Css NA 11.22 mg/L PBTK NA 95% Rat Human +DTXSID7026102 Vd NA 1.32 L/kg 1compartment NA NA Rat Human +DTXSID7026102 Days.Css NA 15 Days PBTK NA NA Rat Human +DTXSID7026102 TK.Half.Life NA 54.84 hours 1compartment NA NA Rat Human +DTXSID7026102 Css NA 1.549 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026102 Css NA 4.954 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026102 Css NA 0.9878 mg/L PBTK NA 50% Rat Human +DTXSID7026102 Css NA 2.905 mg/L PBTK NA 95% Rat Human DTXSID7026108 Clint NA 126.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7026108 Fup NA 0.9487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026108 Vd NA 1.98 L/kg 1compartment NA NA Human Human +DTXSID7026108 Vd NA 1.385 L/kg 1compartment NA NA Human Human DTXSID7026108 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026108 TK.Half.Life NA 0.9374 hours 1compartment NA NA Human Human -DTXSID7026108 Css NA 0.003744 mg/L 3compartmentss NA 50% Human Human -DTXSID7026108 Css NA 0.04488 mg/L 3compartmentss NA 95% Human Human -DTXSID7026108 Css NA 0.003722 mg/L PBTK NA 50% Human Human -DTXSID7026108 Css NA 0.03667 mg/L PBTK NA 95% Human Human +DTXSID7026108 TK.Half.Life NA 0.7181 hours 1compartment NA NA Human Human +DTXSID7026108 Css NA 0.001624 mg/L 3compartmentss NA 50% Human Human +DTXSID7026108 Css NA 0.03644 mg/L 3compartmentss NA 95% Human Human +DTXSID7026108 Css NA 0.001501 mg/L PBTK NA 50% Human Human +DTXSID7026108 Css NA 0.02766 mg/L PBTK NA 95% Human Human DTXSID7026108 Clint NA 126.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7026108 Fup NA 0.9487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026108 Vd NA 1.995 L/kg 1compartment NA NA Rat Human +DTXSID7026108 Vd NA 1.416 L/kg 1compartment NA NA Rat Human DTXSID7026108 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026108 TK.Half.Life NA 0.4206 hours 1compartment NA NA Rat Human -DTXSID7026108 Css NA 0.001914 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026108 Css NA 0.02014 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026108 Css NA 0.001938 mg/L PBTK NA 50% Rat Human -DTXSID7026108 Css NA 0.01612 mg/L PBTK NA 95% Rat Human -DTXSID7026156 Clint NA 9.928 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026156 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026156 Vd NA 0.5876 L/kg 1compartment NA NA Human Human +DTXSID7026108 TK.Half.Life NA 0.3253 hours 1compartment NA NA Rat Human +DTXSID7026108 Css NA 5.218e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026108 Css NA 0.001537 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026108 Css NA 4.836e-05 mg/L PBTK NA 50% Rat Human +DTXSID7026108 Css NA 0.001163 mg/L PBTK NA 95% Rat Human +DTXSID7026156 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026156 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026156 Vd NA 0.5159 L/kg 1compartment NA NA Human Human DTXSID7026156 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026156 TK.Half.Life NA 1.089 hours 1compartment NA NA Human Human -DTXSID7026156 Css NA 0.1448 mg/L 3compartmentss NA 50% Human Human -DTXSID7026156 Css NA 0.9769 mg/L 3compartmentss NA 95% Human Human -DTXSID7026156 Css NA 0.1033 mg/L PBTK NA 50% Human Human -DTXSID7026156 Css NA 0.6322 mg/L PBTK NA 95% Human Human -DTXSID7026156 Clint NA 9.928 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026156 Fup NA 0.317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026156 Vd NA 0.5659 L/kg 1compartment NA NA Rat Human +DTXSID7026156 TK.Half.Life NA 0.7522 hours 1compartment NA NA Human Human +DTXSID7026156 Css NA 0.085 mg/L 3compartmentss NA 50% Human Human +DTXSID7026156 Css NA 0.6153 mg/L 3compartmentss NA 95% Human Human +DTXSID7026156 Css NA 0.05794 mg/L PBTK NA 50% Human Human +DTXSID7026156 Css NA 0.3986 mg/L PBTK NA 95% Human Human +DTXSID7026156 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026156 Fup 0.251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026156 Vd NA 0.4967 L/kg 1compartment NA NA Rat Human DTXSID7026156 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026156 TK.Half.Life NA 0.5849 hours 1compartment NA NA Rat Human -DTXSID7026156 Css NA 0.07512 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026156 Css NA 0.3828 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026156 Css NA 0.05148 mg/L PBTK NA 50% Rat Human -DTXSID7026156 Css NA 0.2353 mg/L PBTK NA 95% Rat Human -DTXSID7026231 Clint NA 407.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026231 Fup NA 0.0089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026231 Vd NA 1.34 L/kg 1compartment NA NA Human Human +DTXSID7026156 TK.Half.Life NA 0.3907 hours 1compartment NA NA Rat Human +DTXSID7026156 Css NA 0.01063 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026156 Css NA 0.05831 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026156 Css NA 0.007192 mg/L PBTK NA 50% Rat Human +DTXSID7026156 Css NA 0.03601 mg/L PBTK NA 95% Rat Human +DTXSID7026231 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026231 Fup 0.0292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026231 Vd NA 1.431 L/kg 1compartment NA NA Human Human DTXSID7026231 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026231 TK.Half.Life NA 2.35 hours 1compartment NA NA Human Human -DTXSID7026231 Css NA 0.1492 mg/L 3compartmentss NA 50% Human Human -DTXSID7026231 Css NA 1.42 mg/L 3compartmentss NA 95% Human Human -DTXSID7026231 Css NA 0.09113 mg/L PBTK NA 50% Human Human -DTXSID7026231 Css NA 0.8442 mg/L PBTK NA 95% Human Human -DTXSID7026231 Clint NA 407.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026231 Fup NA 0.0089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026231 Vd NA 0.9866 L/kg 1compartment NA NA Rat Human +DTXSID7026231 TK.Half.Life NA 9.889 hours 1compartment NA NA Human Human +DTXSID7026231 Css NA 1.037 mg/L 3compartmentss NA 50% Human Human +DTXSID7026231 Css NA 9.283 mg/L 3compartmentss NA 95% Human Human +DTXSID7026231 Css NA 0.6513 mg/L PBTK NA 50% Human Human +DTXSID7026231 Css NA 5.637 mg/L PBTK NA 95% Human Human +DTXSID7026231 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026231 Fup 0.0292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026231 Vd NA 1.066 L/kg 1compartment NA NA Rat Human DTXSID7026231 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026231 TK.Half.Life NA 0.8605 hours 1compartment NA NA Rat Human -DTXSID7026231 Css NA 0.08494 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026231 Css NA 0.7349 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026231 Css NA 0.04898 mg/L PBTK NA 50% Rat Human -DTXSID7026231 Css NA 0.4104 mg/L PBTK NA 95% Rat Human +DTXSID7026231 TK.Half.Life NA 3.881 hours 1compartment NA NA Rat Human +DTXSID7026231 Css NA 0.1335 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026231 Css NA 0.9551 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026231 Css NA 0.08137 mg/L PBTK NA 50% Rat Human +DTXSID7026231 Css NA 0.5623 mg/L PBTK NA 95% Rat Human DTXSID7026235 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7026235 Fup NA 0.2583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026235 Vd NA 0.3649 L/kg 1compartment NA NA Human Human -DTXSID7026235 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026235 TK.Half.Life NA 9.141 hours 1compartment NA NA Human Human -DTXSID7026235 Css NA 3.053 mg/L 3compartmentss NA 50% Human Human -DTXSID7026235 Css NA 11.63 mg/L 3compartmentss NA 95% Human Human -DTXSID7026235 Css NA 2.046 mg/L PBTK NA 50% Human Human -DTXSID7026235 Css NA 7.182 mg/L PBTK NA 95% Human Human +DTXSID7026235 Vd NA 0.4212 L/kg 1compartment NA NA Human Human +DTXSID7026235 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7026235 TK.Half.Life NA 10.55 hours 1compartment NA NA Human Human +DTXSID7026235 Css NA 2.911 mg/L 3compartmentss NA 50% Human Human +DTXSID7026235 Css NA 10.88 mg/L 3compartmentss NA 95% Human Human +DTXSID7026235 Css NA 1.994 mg/L PBTK NA 50% Human Human +DTXSID7026235 Css NA 6.74 mg/L PBTK NA 95% Human Human DTXSID7026235 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7026235 Fup NA 0.2583 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026235 Vd NA 0.3778 L/kg 1compartment NA NA Rat Human +DTXSID7026235 Vd NA 0.4283 L/kg 1compartment NA NA Rat Human DTXSID7026235 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026235 TK.Half.Life NA 3.225 hours 1compartment NA NA Rat Human -DTXSID7026235 Css NA 0.8508 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026235 Css NA 2.644 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026235 Css NA 0.5386 mg/L PBTK NA 50% Rat Human -DTXSID7026235 Css NA 1.515 mg/L PBTK NA 95% Rat Human -DTXSID7026285 Clint NA 150.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026285 Fup NA 0.527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026285 Vd NA 1.061 L/kg 1compartment NA NA Human Human +DTXSID7026235 TK.Half.Life NA 3.656 hours 1compartment NA NA Rat Human +DTXSID7026235 Css NA 0.1868 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026235 Css NA 0.6073 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026235 Css NA 0.1257 mg/L PBTK NA 50% Rat Human +DTXSID7026235 Css NA 0.3637 mg/L PBTK NA 95% Rat Human +DTXSID7026285 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026285 Fup 0.435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026285 Vd NA 0.949 L/kg 1compartment NA NA Human Human DTXSID7026285 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026285 TK.Half.Life NA 0.7289 hours 1compartment NA NA Human Human -DTXSID7026285 Css NA 0.005748 mg/L 3compartmentss NA 50% Human Human -DTXSID7026285 Css NA 0.05603 mg/L 3compartmentss NA 95% Human Human -DTXSID7026285 Css NA 0.004721 mg/L PBTK NA 50% Human Human -DTXSID7026285 Css NA 0.03964 mg/L PBTK NA 95% Human Human -DTXSID7026285 Clint NA 150.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026285 Fup NA 0.527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026285 Vd NA 0.9631 L/kg 1compartment NA NA Rat Human +DTXSID7026285 TK.Half.Life NA 1.006 hours 1compartment NA NA Human Human +DTXSID7026285 Css NA 0.04404 mg/L 3compartmentss NA 50% Human Human +DTXSID7026285 Css NA 0.3719 mg/L 3compartmentss NA 95% Human Human +DTXSID7026285 Css NA 0.0347 mg/L PBTK NA 50% Human Human +DTXSID7026285 Css NA 0.2577 mg/L PBTK NA 95% Human Human +DTXSID7026285 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026285 Fup 0.435 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026285 Vd NA 0.8602 L/kg 1compartment NA NA Rat Human DTXSID7026285 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026285 TK.Half.Life NA 0.2948 hours 1compartment NA NA Rat Human -DTXSID7026285 Css NA 0.003133 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026285 Css NA 0.02725 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026285 Css NA 0.002489 mg/L PBTK NA 50% Rat Human -DTXSID7026285 Css NA 0.01802 mg/L PBTK NA 95% Rat Human -DTXSID7026314 Clint NA 6.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026314 Fup NA 0.5092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026314 Vd NA 0.6405 L/kg 1compartment NA NA Human Human -DTXSID7026314 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026314 TK.Half.Life NA 1.036 hours 1compartment NA NA Human Human -DTXSID7026314 Css NA 0.1247 mg/L 3compartmentss NA 50% Human Human -DTXSID7026314 Css NA 0.879 mg/L 3compartmentss NA 95% Human Human -DTXSID7026314 Css NA 0.09542 mg/L PBTK NA 50% Human Human -DTXSID7026314 Css NA 0.5827 mg/L PBTK NA 95% Human Human -DTXSID7026314 Clint NA 6.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026314 Fup NA 0.5092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026314 Vd NA 0.6447 L/kg 1compartment NA NA Rat Human -DTXSID7026314 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026314 TK.Half.Life NA 0.5686 hours 1compartment NA NA Rat Human -DTXSID7026314 Css NA 0.06208 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026314 Css NA 0.3834 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026314 Css NA 0.04562 mg/L PBTK NA 50% Rat Human -DTXSID7026314 Css NA 0.2343 mg/L PBTK NA 95% Rat Human -DTXSID7026318 Clint NA 4.455 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026318 Fup NA 0.0423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026318 Vd NA 3.097 L/kg 1compartment NA NA Human Human -DTXSID7026318 Days.Css NA 70 Days PBTK NA NA Human Human -DTXSID7026318 TK.Half.Life NA 319.9 hours 1compartment NA NA Human Human -DTXSID7026318 Css NA 12.92 mg/L 3compartmentss NA 50% Human Human -DTXSID7026318 Css NA 78.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7026318 Css NA 8.954 mg/L PBTK NA 50% Human Human -DTXSID7026318 Css NA 52.06 mg/L PBTK NA 95% Human Human -DTXSID7026318 Clint NA 4.455 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026318 Fup NA 0.0423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026318 Vd NA 2.322 L/kg 1compartment NA NA Rat Human -DTXSID7026318 Days.Css NA 38 Days PBTK NA NA Rat Human -DTXSID7026318 TK.Half.Life NA 42.71 hours 1compartment NA NA Rat Human -DTXSID7026318 Css NA 7.185 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026318 Css NA 34.11 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026318 Css NA 4.772 mg/L PBTK NA 50% Rat Human -DTXSID7026318 Css NA 21.57 mg/L PBTK NA 95% Rat Human -DTXSID7026368 Clint NA 0.3335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026368 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026368 Vd NA 0.2448 L/kg 1compartment NA NA Human Human +DTXSID7026285 TK.Half.Life NA 0.4618 hours 1compartment NA NA Rat Human +DTXSID7026285 Css NA 0.005421 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026285 Css NA 0.03588 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026285 Css NA 0.004285 mg/L PBTK NA 50% Rat Human +DTXSID7026285 Css NA 0.02464 mg/L PBTK NA 95% Rat Human +DTXSID7026368 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026368 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026368 Vd NA 0.2969 L/kg 1compartment NA NA Human Human DTXSID7026368 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026368 TK.Half.Life NA 8.326 hours 1compartment NA NA Human Human -DTXSID7026368 Css NA 5.162 mg/L 3compartmentss NA 50% Human Human -DTXSID7026368 Css NA 24.62 mg/L 3compartmentss NA 95% Human Human -DTXSID7026368 Css NA 3.149 mg/L PBTK NA 50% Human Human -DTXSID7026368 Css NA 14.45 mg/L PBTK NA 95% Human Human -DTXSID7026368 Clint NA 0.3335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026368 Fup NA 0.123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7026368 TK.Half.Life NA 0.4878 hours 1compartment NA NA Human Human +DTXSID7026368 Css NA 0.1042 mg/L 3compartmentss NA 50% Human Human +DTXSID7026368 Css NA 0.742 mg/L 3compartmentss NA 95% Human Human +DTXSID7026368 Css NA 0.06672 mg/L PBTK NA 50% Human Human +DTXSID7026368 Css NA 0.4612 mg/L PBTK NA 95% Human Human +DTXSID7026368 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026368 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7026368 Vd NA 0.4128 L/kg 1compartment NA NA Rat Human DTXSID7026368 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026368 TK.Half.Life NA 1.801 hours 1compartment NA NA Rat Human -DTXSID7026368 Css NA 0.4131 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026368 Css NA 1.564 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026368 Css NA 0.2746 mg/L PBTK NA 50% Rat Human -DTXSID7026368 Css NA 0.9052 mg/L PBTK NA 95% Rat Human -DTXSID7026499 Clint NA 2.705 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026499 Fup NA 0.2412 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026499 Vd NA 1.187 L/kg 1compartment NA NA Human Human +DTXSID7026368 TK.Half.Life NA 0.2501 hours 1compartment NA NA Rat Human +DTXSID7026368 Css NA 0.006418 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026368 Css NA 0.03908 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026368 Css NA 0.004428 mg/L PBTK NA 50% Rat Human +DTXSID7026368 Css NA 0.02467 mg/L PBTK NA 95% Rat Human +DTXSID7026499 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026499 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026499 Vd NA 0.8932 L/kg 1compartment NA NA Human Human DTXSID7026499 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026499 TK.Half.Life NA 7.009 hours 1compartment NA NA Human Human -DTXSID7026499 Css NA 0.6402 mg/L 3compartmentss NA 50% Human Human -DTXSID7026499 Css NA 3.296 mg/L 3compartmentss NA 95% Human Human -DTXSID7026499 Css NA 0.465 mg/L PBTK NA 50% Human Human -DTXSID7026499 Css NA 2.196 mg/L PBTK NA 95% Human Human -DTXSID7026499 Clint NA 2.705 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026499 Fup NA 0.2412 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026499 Vd NA 0.973 L/kg 1compartment NA NA Rat Human +DTXSID7026499 TK.Half.Life NA 4.398 hours 1compartment NA NA Human Human +DTXSID7026499 Css NA 0.5392 mg/L 3compartmentss NA 50% Human Human +DTXSID7026499 Css NA 3.782 mg/L 3compartmentss NA 95% Human Human +DTXSID7026499 Css NA 0.3571 mg/L PBTK NA 50% Human Human +DTXSID7026499 Css NA 2.31 mg/L PBTK NA 95% Human Human +DTXSID7026499 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026499 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026499 Vd NA 0.7277 L/kg 1compartment NA NA Rat Human DTXSID7026499 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026499 TK.Half.Life NA 2.933 hours 1compartment NA NA Rat Human -DTXSID7026499 Css NA 0.301 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026499 Css NA 1.093 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026499 Css NA 0.2097 mg/L PBTK NA 50% Rat Human -DTXSID7026499 Css NA 0.6749 mg/L PBTK NA 95% Rat Human -DTXSID7026520 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026520 Fup NA 0.2753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026520 Vd NA 0.472 L/kg 1compartment NA NA Human Human -DTXSID7026520 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7026520 TK.Half.Life NA 11.15 hours 1compartment NA NA Human Human -DTXSID7026520 Css NA 2.829 mg/L 3compartmentss NA 50% Human Human -DTXSID7026520 Css NA 10.91 mg/L 3compartmentss NA 95% Human Human -DTXSID7026520 Css NA 1.933 mg/L PBTK NA 50% Human Human -DTXSID7026520 Css NA 6.697 mg/L PBTK NA 95% Human Human -DTXSID7026520 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026520 Fup NA 0.2753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026520 Vd NA 0.4604 L/kg 1compartment NA NA Rat Human +DTXSID7026499 TK.Half.Life NA 2.038 hours 1compartment NA NA Rat Human +DTXSID7026499 Css NA 0.02466 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026499 Css NA 0.1971 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026499 Css NA 0.01594 mg/L PBTK NA 50% Rat Human +DTXSID7026499 Css NA 0.1181 mg/L PBTK NA 95% Rat Human +DTXSID7026520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026520 Fup 0.0728 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026520 Vd NA 2.235 L/kg 1compartment NA NA Human Human +DTXSID7026520 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7026520 TK.Half.Life NA 10.41 hours 1compartment NA NA Human Human +DTXSID7026520 Css NA 0.5429 mg/L 3compartmentss NA 50% Human Human +DTXSID7026520 Css NA 3.869 mg/L 3compartmentss NA 95% Human Human +DTXSID7026520 Css NA 0.3622 mg/L PBTK NA 50% Human Human +DTXSID7026520 Css NA 2.478 mg/L PBTK NA 95% Human Human +DTXSID7026520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026520 Fup 0.0728 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026520 Vd NA 1.678 L/kg 1compartment NA NA Rat Human DTXSID7026520 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026520 TK.Half.Life NA 3.691 hours 1compartment NA NA Rat Human -DTXSID7026520 Css NA 0.7786 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026520 Css NA 2.555 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026520 Css NA 0.5056 mg/L PBTK NA 50% Rat Human -DTXSID7026520 Css NA 1.475 mg/L PBTK NA 95% Rat Human -DTXSID7026526 Clint NA 2.958 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026526 Fup NA 0.3846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026526 Vd NA 0.4306 L/kg 1compartment NA NA Human Human +DTXSID7026520 TK.Half.Life NA 3.081 hours 1compartment NA NA Rat Human +DTXSID7026520 Css NA 0.07132 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026520 Css NA 0.3917 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026520 Css NA 0.04706 mg/L PBTK NA 50% Rat Human +DTXSID7026520 Css NA 0.2491 mg/L PBTK NA 95% Rat Human +DTXSID7026526 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026526 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026526 Vd NA 0.4423 L/kg 1compartment NA NA Human Human DTXSID7026526 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026526 TK.Half.Life NA 1.242 hours 1compartment NA NA Human Human -DTXSID7026526 Css NA 0.2841 mg/L 3compartmentss NA 50% Human Human -DTXSID7026526 Css NA 1.694 mg/L 3compartmentss NA 95% Human Human -DTXSID7026526 Css NA 0.2006 mg/L PBTK NA 50% Human Human -DTXSID7026526 Css NA 1.077 mg/L PBTK NA 95% Human Human -DTXSID7026526 Clint NA 2.958 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026526 Fup NA 0.3846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026526 Vd NA 0.4505 L/kg 1compartment NA NA Rat Human +DTXSID7026526 TK.Half.Life NA 0.8504 hours 1compartment NA NA Human Human +DTXSID7026526 Css NA 0.1504 mg/L 3compartmentss NA 50% Human Human +DTXSID7026526 Css NA 0.9849 mg/L 3compartmentss NA 95% Human Human +DTXSID7026526 Css NA 0.1065 mg/L PBTK NA 50% Human Human +DTXSID7026526 Css NA 0.6472 mg/L PBTK NA 95% Human Human +DTXSID7026526 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026526 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026526 Vd NA 0.4604 L/kg 1compartment NA NA Rat Human DTXSID7026526 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026526 TK.Half.Life NA 0.7237 hours 1compartment NA NA Rat Human -DTXSID7026526 Css NA 0.1369 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026526 Css NA 0.6069 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026526 Css NA 0.09249 mg/L PBTK NA 50% Rat Human -DTXSID7026526 Css NA 0.3624 mg/L PBTK NA 95% Rat Human -DTXSID7026528 Clint NA 2.462 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026528 Fup NA 0.2038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026528 Vd NA 0.2991 L/kg 1compartment NA NA Human Human +DTXSID7026526 TK.Half.Life NA 0.4923 hours 1compartment NA NA Rat Human +DTXSID7026526 Css NA 0.01767 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026526 Css NA 0.09151 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026526 Css NA 0.0124 mg/L PBTK NA 50% Rat Human +DTXSID7026526 Css NA 0.05727 mg/L PBTK NA 95% Rat Human +DTXSID7026528 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026528 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026528 Vd NA 0.3445 L/kg 1compartment NA NA Human Human DTXSID7026528 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026528 TK.Half.Life NA 1.76 hours 1compartment NA NA Human Human -DTXSID7026528 Css NA 0.7021 mg/L 3compartmentss NA 50% Human Human -DTXSID7026528 Css NA 3.357 mg/L 3compartmentss NA 95% Human Human -DTXSID7026528 Css NA 0.4522 mg/L PBTK NA 50% Human Human -DTXSID7026528 Css NA 2.061 mg/L PBTK NA 95% Human Human -DTXSID7026528 Clint NA 2.462 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026528 Fup NA 0.2038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026528 Vd NA 0.3093 L/kg 1compartment NA NA Rat Human +DTXSID7026528 TK.Half.Life NA 0.8266 hours 1compartment NA NA Human Human +DTXSID7026528 Css NA 0.2108 mg/L 3compartmentss NA 50% Human Human +DTXSID7026528 Css NA 1.383 mg/L 3compartmentss NA 95% Human Human +DTXSID7026528 Css NA 0.1399 mg/L PBTK NA 50% Human Human +DTXSID7026528 Css NA 0.8743 mg/L PBTK NA 95% Human Human +DTXSID7026528 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026528 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026528 Vd NA 0.3578 L/kg 1compartment NA NA Rat Human DTXSID7026528 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026528 TK.Half.Life NA 1.034 hours 1compartment NA NA Rat Human -DTXSID7026528 Css NA 0.3397 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026528 Css NA 1.232 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026528 Css NA 0.2068 mg/L PBTK NA 50% Rat Human -DTXSID7026528 Css NA 0.7008 mg/L PBTK NA 95% Rat Human -DTXSID7026572 Clint NA 25.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026572 Fup NA 0.0616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026572 Vd NA 3.095 L/kg 1compartment NA NA Human Human +DTXSID7026528 TK.Half.Life NA 0.4888 hours 1compartment NA NA Rat Human +DTXSID7026528 Css NA 0.02547 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026528 Css NA 0.1178 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026528 Css NA 0.01666 mg/L PBTK NA 50% Rat Human +DTXSID7026528 Css NA 0.07225 mg/L PBTK NA 95% Rat Human +DTXSID7026572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026572 Fup 0.0713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026572 Vd NA 3.129 L/kg 1compartment NA NA Human Human DTXSID7026572 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7026572 TK.Half.Life NA 17.4 hours 1compartment NA NA Human Human -DTXSID7026572 Css NA 0.6291 mg/L 3compartmentss NA 50% Human Human -DTXSID7026572 Css NA 4.056 mg/L 3compartmentss NA 95% Human Human -DTXSID7026572 Css NA 0.4486 mg/L PBTK NA 50% Human Human -DTXSID7026572 Css NA 2.846 mg/L PBTK NA 95% Human Human -DTXSID7026572 Clint NA 25.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026572 Fup NA 0.0616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026572 Vd NA 2.385 L/kg 1compartment NA NA Rat Human -DTXSID7026572 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026572 TK.Half.Life NA 3.443 hours 1compartment NA NA Rat Human -DTXSID7026572 Css NA 0.3442 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026572 Css NA 1.931 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026572 Css NA 0.2356 mg/L PBTK NA 50% Rat Human -DTXSID7026572 Css NA 1.277 mg/L PBTK NA 95% Rat Human -DTXSID7026605 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026605 Fup NA 0.9811 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026605 Vd NA 0.705 L/kg 1compartment NA NA Human Human +DTXSID7026572 TK.Half.Life NA 19.94 hours 1compartment NA NA Human Human +DTXSID7026572 Css NA 0.668 mg/L 3compartmentss NA 50% Human Human +DTXSID7026572 Css NA 4.635 mg/L 3compartmentss NA 95% Human Human +DTXSID7026572 Css NA 0.481 mg/L PBTK NA 50% Human Human +DTXSID7026572 Css NA 3.137 mg/L PBTK NA 95% Human Human +DTXSID7026572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026572 Fup 0.0713 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026572 Vd NA 2.412 L/kg 1compartment NA NA Rat Human +DTXSID7026572 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7026572 TK.Half.Life NA 3.788 hours 1compartment NA NA Rat Human +DTXSID7026572 Css NA 0.08679 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026572 Css NA 0.4889 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026572 Css NA 0.06214 mg/L PBTK NA 50% Rat Human +DTXSID7026572 Css NA 0.3436 mg/L PBTK NA 95% Rat Human +DTXSID7026605 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026605 Fup 0.81 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026605 Vd NA 0.6298 L/kg 1compartment NA NA Human Human DTXSID7026605 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026605 TK.Half.Life NA 4.649 hours 1compartment NA NA Human Human -DTXSID7026605 Css NA 0.8491 mg/L 3compartmentss NA 50% Human Human -DTXSID7026605 Css NA 2.833 mg/L 3compartmentss NA 95% Human Human -DTXSID7026605 Css NA 0.7004 mg/L PBTK NA 50% Human Human -DTXSID7026605 Css NA 2.006 mg/L PBTK NA 95% Human Human -DTXSID7026605 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026605 Fup NA 0.9811 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026605 Vd NA 0.7523 L/kg 1compartment NA NA Rat Human +DTXSID7026605 TK.Half.Life NA 5.03 hours 1compartment NA NA Human Human +DTXSID7026605 Css NA 0.5623 mg/L 3compartmentss NA 50% Human Human +DTXSID7026605 Css NA 3.308 mg/L 3compartmentss NA 95% Human Human +DTXSID7026605 Css NA 0.4494 mg/L PBTK NA 50% Human Human +DTXSID7026605 Css NA 2.114 mg/L PBTK NA 95% Human Human +DTXSID7026605 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026605 Fup 0.81 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026605 Vd NA 0.6714 L/kg 1compartment NA NA Rat Human DTXSID7026605 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026605 TK.Half.Life NA 1.691 hours 1compartment NA NA Rat Human -DTXSID7026605 Css NA 0.219 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026605 Css NA 0.6488 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026605 Css NA 0.1762 mg/L PBTK NA 50% Rat Human -DTXSID7026605 Css NA 0.422 mg/L PBTK NA 95% Rat Human -DTXSID7026609 Clint NA 12.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026609 Fup NA 0.7133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026609 Vd NA 1.644 L/kg 1compartment NA NA Human Human -DTXSID7026609 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026609 TK.Half.Life NA 1.653 hours 1compartment NA NA Human Human -DTXSID7026609 Css NA 0.05195 mg/L 3compartmentss NA 50% Human Human -DTXSID7026609 Css NA 0.5114 mg/L 3compartmentss NA 95% Human Human -DTXSID7026609 Css NA 0.04637 mg/L PBTK NA 50% Human Human -DTXSID7026609 Css NA 0.3785 mg/L PBTK NA 95% Human Human -DTXSID7026609 Clint NA 12.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026609 Fup NA 0.7133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026609 Vd NA 1.42 L/kg 1compartment NA NA Rat Human -DTXSID7026609 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026609 TK.Half.Life NA 0.687 hours 1compartment NA NA Rat Human -DTXSID7026609 Css NA 0.0264 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026609 Css NA 0.2156 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026609 Css NA 0.02318 mg/L PBTK NA 50% Rat Human -DTXSID7026609 Css NA 0.1458 mg/L PBTK NA 95% Rat Human -DTXSID7026653 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026653 Fup NA 0.1954 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026653 Vd NA 1.15 L/kg 1compartment NA NA Human Human -DTXSID7026653 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID7026653 TK.Half.Life NA 44.32 hours 1compartment NA NA Human Human -DTXSID7026653 Css NA 4.478 mg/L 3compartmentss NA 50% Human Human -DTXSID7026653 Css NA 16.05 mg/L 3compartmentss NA 95% Human Human -DTXSID7026653 Css NA 3.174 mg/L PBTK NA 50% Human Human -DTXSID7026653 Css NA 10.2 mg/L PBTK NA 95% Human Human -DTXSID7026653 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026653 Fup NA 0.1954 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026653 Vd NA 0.931 L/kg 1compartment NA NA Rat Human -DTXSID7026653 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7026653 TK.Half.Life NA 10.91 hours 1compartment NA NA Rat Human -DTXSID7026653 Css NA 1.229 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026653 Css NA 3.605 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026653 Css NA 0.8273 mg/L PBTK NA 50% Rat Human -DTXSID7026653 Css NA 2.133 mg/L PBTK NA 95% Rat Human -DTXSID7026655 Clint NA 9.274 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026655 Fup NA 0.3273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026655 Vd NA 2.105 L/kg 1compartment NA NA Human Human +DTXSID7026605 TK.Half.Life NA 1.828 hours 1compartment NA NA Rat Human +DTXSID7026605 Css NA 0.00285 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026605 Css NA 0.01758 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026605 Css NA 0.002203 mg/L PBTK NA 50% Rat Human +DTXSID7026605 Css NA 0.01096 mg/L PBTK NA 95% Rat Human +DTXSID7026653 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026653 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026653 Vd NA 0.4468 L/kg 1compartment NA NA Human Human +DTXSID7026653 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7026653 TK.Half.Life NA 1.978 hours 1compartment NA NA Human Human +DTXSID7026653 Css NA 0.5458 mg/L 3compartmentss NA 50% Human Human +DTXSID7026653 Css NA 3.693 mg/L 3compartmentss NA 95% Human Human +DTXSID7026653 Css NA 0.3502 mg/L PBTK NA 50% Human Human +DTXSID7026653 Css NA 2.204 mg/L PBTK NA 95% Human Human +DTXSID7026653 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026653 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026653 Vd NA 0.419 L/kg 1compartment NA NA Rat Human +DTXSID7026653 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7026653 TK.Half.Life NA 1.103 hours 1compartment NA NA Rat Human +DTXSID7026653 Css NA 0.06514 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026653 Css NA 0.3348 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026653 Css NA 0.04109 mg/L PBTK NA 50% Rat Human +DTXSID7026653 Css NA 0.1953 mg/L PBTK NA 95% Rat Human +DTXSID7026655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026655 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026655 Vd NA 1.645 L/kg 1compartment NA NA Human Human DTXSID7026655 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026655 TK.Half.Life NA 5.39 hours 1compartment NA NA Human Human -DTXSID7026655 Css NA 0.225 mg/L 3compartmentss NA 50% Human Human -DTXSID7026655 Css NA 1.344 mg/L 3compartmentss NA 95% Human Human -DTXSID7026655 Css NA 0.1718 mg/L PBTK NA 50% Human Human -DTXSID7026655 Css NA 0.9619 mg/L PBTK NA 95% Human Human -DTXSID7026655 Clint NA 9.274 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026655 Fup NA 0.3273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026655 Vd NA 1.649 L/kg 1compartment NA NA Rat Human +DTXSID7026655 TK.Half.Life NA 3.279 hours 1compartment NA NA Human Human +DTXSID7026655 Css NA 0.151 mg/L 3compartmentss NA 50% Human Human +DTXSID7026655 Css NA 1.077 mg/L 3compartmentss NA 95% Human Human +DTXSID7026655 Css NA 0.1069 mg/L PBTK NA 50% Human Human +DTXSID7026655 Css NA 0.7306 mg/L PBTK NA 95% Human Human +DTXSID7026655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026655 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026655 Vd NA 1.281 L/kg 1compartment NA NA Rat Human DTXSID7026655 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026655 TK.Half.Life NA 1.795 hours 1compartment NA NA Rat Human -DTXSID7026655 Css NA 0.1155 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026655 Css NA 0.5229 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026655 Css NA 0.08586 mg/L PBTK NA 50% Rat Human -DTXSID7026655 Css NA 0.3495 mg/L PBTK NA 95% Rat Human -DTXSID7026863 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026863 Fup NA 0.9236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026863 Vd NA 1.022 L/kg 1compartment NA NA Human Human +DTXSID7026655 TK.Half.Life NA 1.235 hours 1compartment NA NA Rat Human +DTXSID7026655 Css NA 0.01928 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026655 Css NA 0.1001 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026655 Css NA 0.01354 mg/L PBTK NA 50% Rat Human +DTXSID7026655 Css NA 0.06676 mg/L PBTK NA 95% Rat Human +DTXSID7026863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026863 Fup 0.746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026863 Vd NA 0.7731 L/kg 1compartment NA NA Human Human DTXSID7026863 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026863 TK.Half.Life NA 7.169 hours 1compartment NA NA Human Human -DTXSID7026863 Css NA 0.8792 mg/L 3compartmentss NA 50% Human Human -DTXSID7026863 Css NA 5.103 mg/L 3compartmentss NA 95% Human Human -DTXSID7026863 Css NA 0.7592 mg/L PBTK NA 50% Human Human -DTXSID7026863 Css NA 3.35 mg/L PBTK NA 95% Human Human -DTXSID7026863 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026863 Fup NA 0.9236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026863 Vd NA 1.047 L/kg 1compartment NA NA Rat Human +DTXSID7026863 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human +DTXSID7026863 Css NA 0.8929 mg/L 3compartmentss NA 50% Human Human +DTXSID7026863 Css NA 5.43 mg/L 3compartmentss NA 95% Human Human +DTXSID7026863 Css NA 0.7265 mg/L PBTK NA 50% Human Human +DTXSID7026863 Css NA 3.442 mg/L PBTK NA 95% Human Human +DTXSID7026863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026863 Fup 0.746 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026863 Vd NA 0.8051 L/kg 1compartment NA NA Rat Human DTXSID7026863 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026863 TK.Half.Life NA 2.5 hours 1compartment NA NA Rat Human -DTXSID7026863 Css NA 0.2222 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026863 Css NA 1.265 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026863 Css NA 0.1879 mg/L PBTK NA 50% Rat Human -DTXSID7026863 Css NA 0.7764 mg/L PBTK NA 95% Rat Human -DTXSID7026867 Clint NA 4.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026867 Fup NA 0.2833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026867 Vd NA 0.5521 L/kg 1compartment NA NA Human Human +DTXSID7026863 TK.Half.Life NA 2.379 hours 1compartment NA NA Rat Human +DTXSID7026863 Css NA 0.0168 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026863 Css NA 0.136 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026863 Css NA 0.01324 mg/L PBTK NA 50% Rat Human +DTXSID7026863 Css NA 0.08634 mg/L PBTK NA 95% Rat Human +DTXSID7026867 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026867 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7026867 Vd NA 0.5659 L/kg 1compartment NA NA Human Human DTXSID7026867 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7026867 TK.Half.Life NA 1.939 hours 1compartment NA NA Human Human -DTXSID7026867 Css NA 0.3396 mg/L 3compartmentss NA 50% Human Human -DTXSID7026867 Css NA 2.005 mg/L 3compartmentss NA 95% Human Human -DTXSID7026867 Css NA 0.2528 mg/L PBTK NA 50% Human Human -DTXSID7026867 Css NA 1.325 mg/L PBTK NA 95% Human Human -DTXSID7026867 Clint NA 4.073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026867 Fup NA 0.2833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026867 Vd NA 0.5483 L/kg 1compartment NA NA Rat Human +DTXSID7026867 TK.Half.Life NA 9.131 hours 1compartment NA NA Human Human +DTXSID7026867 Css NA 1.696 mg/L 3compartmentss NA 50% Human Human +DTXSID7026867 Css NA 7.718 mg/L 3compartmentss NA 95% Human Human +DTXSID7026867 Css NA 1.293 mg/L PBTK NA 50% Human Human +DTXSID7026867 Css NA 5.033 mg/L PBTK NA 95% Human Human +DTXSID7026867 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026867 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7026867 Vd NA 0.5681 L/kg 1compartment NA NA Rat Human DTXSID7026867 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7026867 TK.Half.Life NA 1.103 hours 1compartment NA NA Rat Human -DTXSID7026867 Css NA 0.1678 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026867 Css NA 0.7204 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026867 Css NA 0.1192 mg/L PBTK NA 50% Rat Human -DTXSID7026867 Css NA 0.448 mg/L PBTK NA 95% Rat Human -DTXSID7026994 Clint NA 26.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026994 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7026994 Vd NA 352.2 L/kg 1compartment NA NA Human Human -DTXSID7026994 Days.Css NA 2337 Days PBTK NA NA Human Human -DTXSID7026994 TK.Half.Life NA 8617 hours 1compartment NA NA Human Human -DTXSID7026994 Css NA 0.03957 mg/L 3compartmentss NA 50% Human Human -DTXSID7026994 Css NA 0.2505 mg/L 3compartmentss NA 95% Human Human -DTXSID7026994 Css NA 2.026 mg/L PBTK NA 50% Human Human -DTXSID7026994 Css NA 11.56 mg/L PBTK NA 95% Human Human -DTXSID7026994 Clint NA 26.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026994 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7026994 Vd NA 315.8 L/kg 1compartment NA NA Rat Human -DTXSID7026994 Days.Css NA 1493 Days PBTK NA NA Rat Human -DTXSID7026994 TK.Half.Life NA 1330 hours 1compartment NA NA Rat Human -DTXSID7026994 Css NA 0.02019 mg/L 3compartmentss NA 50% Rat Human -DTXSID7026994 Css NA 0.09032 mg/L 3compartmentss NA 95% Rat Human -DTXSID7026994 Css NA 1.093 mg/L PBTK NA 50% Rat Human -DTXSID7026994 Css NA 4.86 mg/L PBTK NA 95% Rat Human -DTXSID7027041 Clint NA 99.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027041 Fup NA 0.1315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027041 Vd NA 2.506 L/kg 1compartment NA NA Human Human +DTXSID7026867 TK.Half.Life NA 3.122 hours 1compartment NA NA Rat Human +DTXSID7026867 Css NA 0.1074 mg/L 3compartmentss NA 50% Rat Human +DTXSID7026867 Css NA 0.4255 mg/L 3compartmentss NA 95% Rat Human +DTXSID7026867 Css NA 0.08159 mg/L PBTK NA 50% Rat Human +DTXSID7026867 Css NA 0.2643 mg/L PBTK NA 95% Rat Human +DTXSID7027041 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027041 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027041 Vd NA 2.301 L/kg 1compartment NA NA Human Human DTXSID7027041 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027041 TK.Half.Life NA 3.582 hours 1compartment NA NA Human Human -DTXSID7027041 Css NA 0.08791 mg/L 3compartmentss NA 50% Human Human -DTXSID7027041 Css NA 0.6051 mg/L 3compartmentss NA 95% Human Human -DTXSID7027041 Css NA 0.06112 mg/L PBTK NA 50% Human Human -DTXSID7027041 Css NA 0.4016 mg/L PBTK NA 95% Human Human -DTXSID7027041 Clint NA 99.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027041 Fup NA 0.1315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027041 Vd NA 1.895 L/kg 1compartment NA NA Rat Human +DTXSID7027041 TK.Half.Life NA 4.407 hours 1compartment NA NA Human Human +DTXSID7027041 Css NA 0.137 mg/L 3compartmentss NA 50% Human Human +DTXSID7027041 Css NA 0.9195 mg/L 3compartmentss NA 95% Human Human +DTXSID7027041 Css NA 0.102 mg/L PBTK NA 50% Human Human +DTXSID7027041 Css NA 0.6446 mg/L PBTK NA 95% Human Human +DTXSID7027041 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027041 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027041 Vd NA 1.775 L/kg 1compartment NA NA Rat Human DTXSID7027041 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027041 TK.Half.Life NA 1.058 hours 1compartment NA NA Rat Human -DTXSID7027041 Css NA 0.04878 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027041 Css NA 0.2874 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027041 Css NA 0.03248 mg/L PBTK NA 50% Rat Human -DTXSID7027041 Css NA 0.184 mg/L PBTK NA 95% Rat Human +DTXSID7027041 TK.Half.Life NA 1.373 hours 1compartment NA NA Rat Human +DTXSID7027041 Css NA 0.01727 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027041 Css NA 0.08837 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027041 Css NA 0.01286 mg/L PBTK NA 50% Rat Human +DTXSID7027041 Css NA 0.06257 mg/L PBTK NA 95% Rat Human DTXSID7027043 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7027043 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027043 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID7027043 Vd NA 0.33 L/kg 1compartment NA NA Human Human DTXSID7027043 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027043 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID7027043 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID7027043 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID7027043 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID7027043 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID7027043 TK.Half.Life NA 6.608 hours 1compartment NA NA Human Human +DTXSID7027043 Css NA 2.055 mg/L 3compartmentss NA 50% Human Human +DTXSID7027043 Css NA 8.59 mg/L 3compartmentss NA 95% Human Human +DTXSID7027043 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID7027043 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID7027043 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7027043 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027043 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID7027043 Vd NA 0.3475 L/kg 1compartment NA NA Rat Human DTXSID7027043 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027043 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID7027043 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027043 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027043 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID7027043 Css NA 1.313 mg/L PBTK NA 95% Rat Human +DTXSID7027043 TK.Half.Life NA 2.371 hours 1compartment NA NA Rat Human +DTXSID7027043 Css NA 0.03852 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027043 Css NA 0.2271 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027043 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID7027043 Css NA 0.1369 mg/L PBTK NA 95% Rat Human +DTXSID7027047 Clint 10.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID7027047 Fup 0.006334 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID7027047 Vd NA 2.406 L/kg 1compartment NA NA Human Human +DTXSID7027047 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID7027047 TK.Half.Life NA 99.15 hours 1compartment NA NA Human Human +DTXSID7027047 Css NA 6.248 mg/L 3compartmentss NA 50% Human Human +DTXSID7027047 Css NA 46.61 mg/L 3compartmentss NA 95% Human Human +DTXSID7027047 Css NA 4.068 mg/L PBTK NA 50% Human Human +DTXSID7027047 Css NA 29.27 mg/L PBTK NA 95% Human Human +DTXSID7027047 Clint 10.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID7027047 Fup 0.006334 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID7027047 Vd NA 1.788 L/kg 1compartment NA NA Rat Human +DTXSID7027047 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID7027047 TK.Half.Life NA 25.37 hours 1compartment NA NA Rat Human +DTXSID7027047 Css NA 0.7926 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027047 Css NA 4.941 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027047 Css NA 0.5094 mg/L PBTK NA 50% Rat Human +DTXSID7027047 Css NA 3.062 mg/L PBTK NA 95% Rat Human DTXSID7027097 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7027097 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027097 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID7027097 Vd NA 0.3486 L/kg 1compartment NA NA Human Human DTXSID7027097 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027097 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID7027097 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID7027097 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID7027097 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID7027097 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID7027097 TK.Half.Life NA 6.982 hours 1compartment NA NA Human Human +DTXSID7027097 Css NA 2.037 mg/L 3compartmentss NA 50% Human Human +DTXSID7027097 Css NA 8.567 mg/L 3compartmentss NA 95% Human Human +DTXSID7027097 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID7027097 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID7027097 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7027097 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027097 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID7027097 Vd NA 0.3629 L/kg 1compartment NA NA Rat Human DTXSID7027097 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027097 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID7027097 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027097 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027097 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID7027097 Css NA 1.313 mg/L PBTK NA 95% Rat Human -DTXSID7027099 Clint NA 38.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027099 Fup NA 0.0066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027099 Vd NA 845.8 L/kg 1compartment NA NA Human Human -DTXSID7027099 Days.Css NA 3861 Days PBTK NA NA Human Human -DTXSID7027099 TK.Half.Life NA 14090 hours 1compartment NA NA Human Human -DTXSID7027099 Css NA 0.01046 mg/L 3compartmentss NA 50% Human Human -DTXSID7027099 Css NA 0.06154 mg/L 3compartmentss NA 95% Human Human -DTXSID7027099 Css NA 1.383 mg/L PBTK NA 50% Human Human -DTXSID7027099 Css NA 7.502 mg/L PBTK NA 95% Human Human -DTXSID7027099 Clint NA 38.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027099 Fup NA 0.0066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027099 Vd NA 772.3 L/kg 1compartment NA NA Rat Human -DTXSID7027099 Days.Css NA 2510 Days PBTK NA NA Rat Human -DTXSID7027099 TK.Half.Life NA 2293 hours 1compartment NA NA Rat Human -DTXSID7027099 Css NA 0.005305 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027099 Css NA 0.0226 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027099 Css NA 0.7537 mg/L PBTK NA 50% Rat Human -DTXSID7027099 Css NA 3.059 mg/L PBTK NA 95% Rat Human +DTXSID7027097 TK.Half.Life NA 2.476 hours 1compartment NA NA Rat Human +DTXSID7027097 Css NA 0.03818 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027097 Css NA 0.2261 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027097 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID7027097 Css NA 0.1369 mg/L PBTK NA 95% Rat Human DTXSID7027120 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7027120 Fup NA 0.5307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027120 Vd NA 0.3582 L/kg 1compartment NA NA Human Human +DTXSID7027120 Vd NA 0.3296 L/kg 1compartment NA NA Human Human DTXSID7027120 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027120 TK.Half.Life NA 4.368 hours 1compartment NA NA Human Human -DTXSID7027120 Css NA 1.556 mg/L 3compartmentss NA 50% Human Human -DTXSID7027120 Css NA 8.433 mg/L 3compartmentss NA 95% Human Human -DTXSID7027120 Css NA 1.078 mg/L PBTK NA 50% Human Human -DTXSID7027120 Css NA 5.092 mg/L PBTK NA 95% Human Human +DTXSID7027120 TK.Half.Life NA 4.018 hours 1compartment NA NA Human Human +DTXSID7027120 Css NA 1.318 mg/L 3compartmentss NA 50% Human Human +DTXSID7027120 Css NA 7.172 mg/L 3compartmentss NA 95% Human Human +DTXSID7027120 Css NA 0.9079 mg/L PBTK NA 50% Human Human +DTXSID7027120 Css NA 4.364 mg/L PBTK NA 95% Human Human DTXSID7027120 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7027120 Fup NA 0.5307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027120 Vd NA 0.3748 L/kg 1compartment NA NA Rat Human +DTXSID7027120 Vd NA 0.3509 L/kg 1compartment NA NA Rat Human DTXSID7027120 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027120 TK.Half.Life NA 1.558 hours 1compartment NA NA Rat Human -DTXSID7027120 Css NA 0.4116 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027120 Css NA 2.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027120 Css NA 0.2714 mg/L PBTK NA 50% Rat Human -DTXSID7027120 Css NA 1.143 mg/L PBTK NA 95% Rat Human +DTXSID7027120 TK.Half.Life NA 1.458 hours 1compartment NA NA Rat Human +DTXSID7027120 Css NA 0.02528 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027120 Css NA 0.1771 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027120 Css NA 0.0164 mg/L PBTK NA 50% Rat Human +DTXSID7027120 Css NA 0.1067 mg/L PBTK NA 95% Rat Human +DTXSID7027122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027122 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027122 Vd NA 0.6159 L/kg 1compartment NA NA Human Human +DTXSID7027122 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7027122 TK.Half.Life NA 0.6665 hours 1compartment NA NA Human Human +DTXSID7027122 Css NA 0.03729 mg/L 3compartmentss NA 50% Human Human +DTXSID7027122 Css NA 0.3138 mg/L 3compartmentss NA 95% Human Human +DTXSID7027122 Css NA 0.02766 mg/L PBTK NA 50% Human Human +DTXSID7027122 Css NA 0.2133 mg/L PBTK NA 95% Human Human +DTXSID7027122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027122 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027122 Vd NA 0.6127 L/kg 1compartment NA NA Rat Human +DTXSID7027122 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7027122 TK.Half.Life NA 0.3386 hours 1compartment NA NA Rat Human +DTXSID7027122 Css NA 0.001268 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027122 Css NA 0.01286 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027122 Css NA 0.0009333 mg/L PBTK NA 50% Rat Human +DTXSID7027122 Css NA 0.00848 mg/L PBTK NA 95% Rat Human DTXSID7027170 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7027170 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027170 Vd NA 0.5453 L/kg 1compartment NA NA Human Human +DTXSID7027170 Vd NA 0.5589 L/kg 1compartment NA NA Human Human DTXSID7027170 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027170 TK.Half.Life NA 5.001 hours 1compartment NA NA Human Human -DTXSID7027170 Css NA 1.121 mg/L 3compartmentss NA 50% Human Human -DTXSID7027170 Css NA 7.122 mg/L 3compartmentss NA 95% Human Human -DTXSID7027170 Css NA 0.8713 mg/L PBTK NA 50% Human Human -DTXSID7027170 Css NA 4.478 mg/L PBTK NA 95% Human Human +DTXSID7027170 TK.Half.Life NA 5.127 hours 1compartment NA NA Human Human +DTXSID7027170 Css NA 0.969 mg/L 3compartmentss NA 50% Human Human +DTXSID7027170 Css NA 6.156 mg/L 3compartmentss NA 95% Human Human +DTXSID7027170 Css NA 0.7519 mg/L PBTK NA 50% Human Human +DTXSID7027170 Css NA 3.908 mg/L PBTK NA 95% Human Human DTXSID7027170 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7027170 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027170 Vd NA 0.5854 L/kg 1compartment NA NA Rat Human +DTXSID7027170 Vd NA 0.5966 L/kg 1compartment NA NA Rat Human DTXSID7027170 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027170 TK.Half.Life NA 1.83 hours 1compartment NA NA Rat Human -DTXSID7027170 Css NA 0.2987 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027170 Css NA 1.854 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027170 Css NA 0.2218 mg/L PBTK NA 50% Rat Human -DTXSID7027170 Css NA 1.078 mg/L PBTK NA 95% Rat Human -DTXSID7027174 Clint NA 1.765 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027174 Fup NA 0.3359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027174 Vd NA 1.423 L/kg 1compartment NA NA Human Human +DTXSID7027170 TK.Half.Life NA 1.865 hours 1compartment NA NA Rat Human +DTXSID7027170 Css NA 0.01849 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027170 Css NA 0.1457 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027170 Css NA 0.01393 mg/L PBTK NA 50% Rat Human +DTXSID7027170 Css NA 0.09074 mg/L PBTK NA 95% Rat Human +DTXSID7027174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027174 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027174 Vd NA 1.242 L/kg 1compartment NA NA Human Human DTXSID7027174 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027174 TK.Half.Life NA 8.76 hours 1compartment NA NA Human Human -DTXSID7027174 Css NA 0.6304 mg/L 3compartmentss NA 50% Human Human -DTXSID7027174 Css NA 3.126 mg/L 3compartmentss NA 95% Human Human -DTXSID7027174 Css NA 0.4902 mg/L PBTK NA 50% Human Human -DTXSID7027174 Css NA 2.087 mg/L PBTK NA 95% Human Human -DTXSID7027174 Clint NA 1.765 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027174 Fup NA 0.3359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027174 Vd NA 1.169 L/kg 1compartment NA NA Rat Human +DTXSID7027174 TK.Half.Life NA 1.814 hours 1compartment NA NA Human Human +DTXSID7027174 Css NA 0.086 mg/L 3compartmentss NA 50% Human Human +DTXSID7027174 Css NA 0.6055 mg/L 3compartmentss NA 95% Human Human +DTXSID7027174 Css NA 0.06301 mg/L PBTK NA 50% Human Human +DTXSID7027174 Css NA 0.4134 mg/L PBTK NA 95% Human Human +DTXSID7027174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027174 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027174 Vd NA 1.017 L/kg 1compartment NA NA Rat Human DTXSID7027174 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027174 TK.Half.Life NA 3.345 hours 1compartment NA NA Rat Human -DTXSID7027174 Css NA 0.281 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027174 Css NA 1.006 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027174 Css NA 0.2098 mg/L PBTK NA 50% Rat Human -DTXSID7027174 Css NA 0.6301 mg/L PBTK NA 95% Rat Human -DTXSID7027253 Clint NA 86.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027253 Fup NA 0.6152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027253 Vd NA 0.9382 L/kg 1compartment NA NA Human Human +DTXSID7027174 TK.Half.Life NA 0.7583 hours 1compartment NA NA Rat Human +DTXSID7027174 Css NA 0.01085 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027174 Css NA 0.05881 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027174 Css NA 0.007916 mg/L PBTK NA 50% Rat Human +DTXSID7027174 Css NA 0.03942 mg/L PBTK NA 95% Rat Human +DTXSID7027253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027253 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027253 Vd NA 1.799 L/kg 1compartment NA NA Human Human DTXSID7027253 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027253 TK.Half.Life NA 0.6436 hours 1compartment NA NA Human Human -DTXSID7027253 Css NA 0.008944 mg/L 3compartmentss NA 50% Human Human -DTXSID7027253 Css NA 0.1002 mg/L 3compartmentss NA 95% Human Human -DTXSID7027253 Css NA 0.007313 mg/L PBTK NA 50% Human Human -DTXSID7027253 Css NA 0.07072 mg/L PBTK NA 95% Human Human -DTXSID7027253 Clint NA 86.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027253 Fup NA 0.6152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027253 Vd NA 0.8931 L/kg 1compartment NA NA Rat Human +DTXSID7027253 TK.Half.Life NA 2.056 hours 1compartment NA NA Human Human +DTXSID7027253 Css NA 0.05372 mg/L 3compartmentss NA 50% Human Human +DTXSID7027253 Css NA 0.4176 mg/L 3compartmentss NA 95% Human Human +DTXSID7027253 Css NA 0.04356 mg/L PBTK NA 50% Human Human +DTXSID7027253 Css NA 0.3006 mg/L PBTK NA 95% Human Human +DTXSID7027253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027253 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027253 Vd NA 1.464 L/kg 1compartment NA NA Rat Human DTXSID7027253 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027253 TK.Half.Life NA 0.2776 hours 1compartment NA NA Rat Human -DTXSID7027253 Css NA 0.004644 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027253 Css NA 0.04711 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027253 Css NA 0.003746 mg/L PBTK NA 50% Rat Human -DTXSID7027253 Css NA 0.03119 mg/L PBTK NA 95% Rat Human -DTXSID7027259 Clint NA 1.123 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027259 Fup NA 0.8625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027259 Vd NA 1.14 L/kg 1compartment NA NA Human Human +DTXSID7027253 TK.Half.Life NA 0.7752 hours 1compartment NA NA Rat Human +DTXSID7027253 Css NA 0.0066 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027253 Css NA 0.0394 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027253 Css NA 0.005438 mg/L PBTK NA 50% Rat Human +DTXSID7027253 Css NA 0.02865 mg/L PBTK NA 95% Rat Human +DTXSID7027259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027259 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027259 Vd NA 0.4746 L/kg 1compartment NA NA Human Human DTXSID7027259 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027259 TK.Half.Life NA 3.353 hours 1compartment NA NA Human Human -DTXSID7027259 Css NA 0.3182 mg/L 3compartmentss NA 50% Human Human -DTXSID7027259 Css NA 2.069 mg/L 3compartmentss NA 95% Human Human -DTXSID7027259 Css NA 0.2807 mg/L PBTK NA 50% Human Human -DTXSID7027259 Css NA 1.387 mg/L PBTK NA 95% Human Human -DTXSID7027259 Clint NA 1.123 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027259 Fup NA 0.8625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027259 Vd NA 1.09 L/kg 1compartment NA NA Rat Human +DTXSID7027259 TK.Half.Life NA 0.8262 hours 1compartment NA NA Human Human +DTXSID7027259 Css NA 0.1215 mg/L 3compartmentss NA 50% Human Human +DTXSID7027259 Css NA 0.8657 mg/L 3compartmentss NA 95% Human Human +DTXSID7027259 Css NA 0.08006 mg/L PBTK NA 50% Human Human +DTXSID7027259 Css NA 0.5525 mg/L PBTK NA 95% Human Human +DTXSID7027259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027259 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027259 Vd NA 0.449 L/kg 1compartment NA NA Rat Human DTXSID7027259 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027259 TK.Half.Life NA 1.531 hours 1compartment NA NA Rat Human -DTXSID7027259 Css NA 0.1206 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027259 Css NA 0.7421 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027259 Css NA 0.1062 mg/L PBTK NA 50% Rat Human -DTXSID7027259 Css NA 0.464 mg/L PBTK NA 95% Rat Human -DTXSID7027334 Clint NA 14.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027334 Fup NA 0.206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027334 Vd NA 1.203 L/kg 1compartment NA NA Human Human +DTXSID7027259 TK.Half.Life NA 0.4348 hours 1compartment NA NA Rat Human +DTXSID7027259 Css NA 0.01555 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027259 Css NA 0.08195 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027259 Css NA 0.01008 mg/L PBTK NA 50% Rat Human +DTXSID7027259 Css NA 0.0505 mg/L PBTK NA 95% Rat Human +DTXSID7027334 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027334 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027334 Vd NA 1.49 L/kg 1compartment NA NA Human Human DTXSID7027334 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027334 TK.Half.Life NA 2.488 hours 1compartment NA NA Human Human -DTXSID7027334 Css NA 0.1659 mg/L 3compartmentss NA 50% Human Human -DTXSID7027334 Css NA 1.049 mg/L 3compartmentss NA 95% Human Human -DTXSID7027334 Css NA 0.1184 mg/L PBTK NA 50% Human Human -DTXSID7027334 Css NA 0.7051 mg/L PBTK NA 95% Human Human -DTXSID7027334 Clint NA 14.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027334 Fup NA 0.206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027334 Vd NA 0.9726 L/kg 1compartment NA NA Rat Human +DTXSID7027334 TK.Half.Life NA 1.901 hours 1compartment NA NA Human Human +DTXSID7027334 Css NA 0.06523 mg/L 3compartmentss NA 50% Human Human +DTXSID7027334 Css NA 0.5101 mg/L 3compartmentss NA 95% Human Human +DTXSID7027334 Css NA 0.05071 mg/L PBTK NA 50% Human Human +DTXSID7027334 Css NA 0.3615 mg/L PBTK NA 95% Human Human +DTXSID7027334 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027334 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027334 Vd NA 1.218 L/kg 1compartment NA NA Rat Human DTXSID7027334 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027334 TK.Half.Life NA 1.065 hours 1compartment NA NA Rat Human -DTXSID7027334 Css NA 0.08924 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027334 Css NA 0.4279 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027334 Css NA 0.06068 mg/L PBTK NA 50% Rat Human -DTXSID7027334 Css NA 0.2778 mg/L PBTK NA 95% Rat Human -DTXSID7027386 Clint NA 2.651 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027386 Fup NA 0.0465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027386 Vd NA 3.095 L/kg 1compartment NA NA Human Human -DTXSID7027386 Days.Css NA 119 Days PBTK NA NA Human Human -DTXSID7027386 TK.Half.Life NA 506.7 hours 1compartment NA NA Human Human -DTXSID7027386 Css NA 20.21 mg/L 3compartmentss NA 50% Human Human -DTXSID7027386 Css NA 120.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7027386 Css NA 14.12 mg/L PBTK NA 50% Human Human -DTXSID7027386 Css NA 82.96 mg/L PBTK NA 95% Human Human -DTXSID7027386 Clint NA 2.651 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027386 Fup NA 0.0465 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027386 Vd NA 2.319 L/kg 1compartment NA NA Rat Human -DTXSID7027386 Days.Css NA 63 Days PBTK NA NA Rat Human -DTXSID7027386 TK.Half.Life NA 66.71 hours 1compartment NA NA Rat Human -DTXSID7027386 Css NA 11.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027386 Css NA 50.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027386 Css NA 7.411 mg/L PBTK NA 50% Rat Human -DTXSID7027386 Css NA 32.78 mg/L PBTK NA 95% Rat Human -DTXSID7027388 Clint NA 129 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027388 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027388 Vd NA 48.51 L/kg 1compartment NA NA Human Human -DTXSID7027388 Days.Css NA 47 Days PBTK NA NA Human Human -DTXSID7027388 TK.Half.Life NA 246 hours 1compartment NA NA Human Human -DTXSID7027388 Css NA 0.07725 mg/L 3compartmentss NA 50% Human Human -DTXSID7027388 Css NA 0.4667 mg/L 3compartmentss NA 95% Human Human -DTXSID7027388 Css NA 0.4138 mg/L PBTK NA 50% Human Human -DTXSID7027388 Css NA 2.333 mg/L PBTK NA 95% Human Human -DTXSID7027388 Clint NA 129 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027388 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027388 Vd NA 40.85 L/kg 1compartment NA NA Rat Human -DTXSID7027388 Days.Css NA 32 Days PBTK NA NA Rat Human -DTXSID7027388 TK.Half.Life NA 37.17 hours 1compartment NA NA Rat Human -DTXSID7027388 Css NA 0.03975 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027388 Css NA 0.1735 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027388 Css NA 0.2223 mg/L PBTK NA 50% Rat Human -DTXSID7027388 Css NA 0.9489 mg/L PBTK NA 95% Rat Human +DTXSID7027334 TK.Half.Life NA 0.7585 hours 1compartment NA NA Rat Human +DTXSID7027334 Css NA 0.008122 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027334 Css NA 0.04788 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027334 Css NA 0.006282 mg/L PBTK NA 50% Rat Human +DTXSID7027334 Css NA 0.03352 mg/L PBTK NA 95% Rat Human DTXSID7027413 Clint NA 0.017 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7027413 Fup NA 0.6173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027413 Vd NA 0.3993 L/kg 1compartment NA NA Human Human +DTXSID7027413 Vd NA 0.3751 L/kg 1compartment NA NA Human Human DTXSID7027413 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027413 TK.Half.Life NA 4.068 hours 1compartment NA NA Human Human -DTXSID7027413 Css NA 1.303 mg/L 3compartmentss NA 50% Human Human -DTXSID7027413 Css NA 8.117 mg/L 3compartmentss NA 95% Human Human -DTXSID7027413 Css NA 0.9253 mg/L PBTK NA 50% Human Human -DTXSID7027413 Css NA 4.892 mg/L PBTK NA 95% Human Human +DTXSID7027413 TK.Half.Life NA 3.796 hours 1compartment NA NA Human Human +DTXSID7027413 Css NA 1.102 mg/L 3compartmentss NA 50% Human Human +DTXSID7027413 Css NA 6.936 mg/L 3compartmentss NA 95% Human Human +DTXSID7027413 Css NA 0.7754 mg/L PBTK NA 50% Human Human +DTXSID7027413 Css NA 4.203 mg/L PBTK NA 95% Human Human DTXSID7027413 Clint NA 0.017 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7027413 Fup NA 0.6173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027413 Vd NA 0.4209 L/kg 1compartment NA NA Rat Human +DTXSID7027413 Vd NA 0.4011 L/kg 1compartment NA NA Rat Human DTXSID7027413 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027413 TK.Half.Life NA 1.482 hours 1compartment NA NA Rat Human -DTXSID7027413 Css NA 0.3545 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027413 Css NA 2.117 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027413 Css NA 0.2396 mg/L PBTK NA 50% Rat Human -DTXSID7027413 Css NA 1.2 mg/L PBTK NA 95% Rat Human +DTXSID7027413 TK.Half.Life NA 1.409 hours 1compartment NA NA Rat Human +DTXSID7027413 Css NA 0.02187 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027413 Css NA 0.1683 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027413 Css NA 0.01462 mg/L PBTK NA 50% Rat Human +DTXSID7027413 Css NA 0.1015 mg/L PBTK NA 95% Rat Human +DTXSID70274236 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70274236 Fup 0.0798 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70274236 Vd NA 1.935 L/kg 1compartment NA NA Human Human +DTXSID70274236 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70274236 TK.Half.Life NA 7.337 hours 1compartment NA NA Human Human +DTXSID70274236 Css NA 0.442 mg/L 3compartmentss NA 50% Human Human +DTXSID70274236 Css NA 3.174 mg/L 3compartmentss NA 95% Human Human +DTXSID70274236 Css NA 0.2944 mg/L PBTK NA 50% Human Human +DTXSID70274236 Css NA 2.005 mg/L PBTK NA 95% Human Human +DTXSID70274236 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70274236 Fup 0.0798 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70274236 Vd NA 1.46 L/kg 1compartment NA NA Rat Human +DTXSID70274236 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70274236 TK.Half.Life NA 2.478 hours 1compartment NA NA Rat Human +DTXSID70274236 Css NA 0.0573 mg/L 3compartmentss NA 50% Rat Human +DTXSID70274236 Css NA 0.3198 mg/L 3compartmentss NA 95% Rat Human +DTXSID70274236 Css NA 0.03759 mg/L PBTK NA 50% Rat Human +DTXSID70274236 Css NA 0.1981 mg/L PBTK NA 95% Rat Human DTXSID7027461 Clint NA 1.555 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7027461 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027461 Vd NA 0.784 L/kg 1compartment NA NA Human Human +DTXSID7027461 Vd NA 0.7972 L/kg 1compartment NA NA Human Human DTXSID7027461 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027461 TK.Half.Life NA 1.649 hours 1compartment NA NA Human Human -DTXSID7027461 Css NA 0.2376 mg/L 3compartmentss NA 50% Human Human -DTXSID7027461 Css NA 1.68 mg/L 3compartmentss NA 95% Human Human -DTXSID7027461 Css NA 0.1986 mg/L PBTK NA 50% Human Human -DTXSID7027461 Css NA 1.146 mg/L PBTK NA 95% Human Human +DTXSID7027461 TK.Half.Life NA 1.678 hours 1compartment NA NA Human Human +DTXSID7027461 Css NA 0.1966 mg/L 3compartmentss NA 50% Human Human +DTXSID7027461 Css NA 1.389 mg/L 3compartmentss NA 95% Human Human +DTXSID7027461 Css NA 0.1647 mg/L PBTK NA 50% Human Human +DTXSID7027461 Css NA 0.9683 mg/L PBTK NA 95% Human Human DTXSID7027461 Clint NA 1.555 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7027461 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027461 Vd NA 0.821 L/kg 1compartment NA NA Rat Human +DTXSID7027461 Vd NA 0.8324 L/kg 1compartment NA NA Rat Human DTXSID7027461 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027461 TK.Half.Life NA 0.8674 hours 1compartment NA NA Rat Human -DTXSID7027461 Css NA 0.09486 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027461 Css NA 0.6215 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027461 Css NA 0.07897 mg/L PBTK NA 50% Rat Human -DTXSID7027461 Css NA 0.3793 mg/L PBTK NA 95% Rat Human -DTXSID7027540 Clint NA 5.509 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027540 Fup NA 0.1809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027540 Vd NA 1.047 L/kg 1compartment NA NA Human Human +DTXSID7027461 TK.Half.Life NA 0.8794 hours 1compartment NA NA Rat Human +DTXSID7027461 Css NA 0.005531 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027461 Css NA 0.0496 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027461 Css NA 0.004552 mg/L PBTK NA 50% Rat Human +DTXSID7027461 Css NA 0.03282 mg/L PBTK NA 95% Rat Human +DTXSID7027540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027540 Fup 0.235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027540 Vd NA 1.213 L/kg 1compartment NA NA Human Human DTXSID7027540 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027540 TK.Half.Life NA 4.618 hours 1compartment NA NA Human Human -DTXSID7027540 Css NA 0.4695 mg/L 3compartmentss NA 50% Human Human -DTXSID7027540 Css NA 2.617 mg/L 3compartmentss NA 95% Human Human -DTXSID7027540 Css NA 0.3256 mg/L PBTK NA 50% Human Human -DTXSID7027540 Css NA 1.701 mg/L PBTK NA 95% Human Human -DTXSID7027540 Clint NA 5.509 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027540 Fup NA 0.1809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027540 Vd NA 0.853 L/kg 1compartment NA NA Rat Human +DTXSID7027540 TK.Half.Life NA 1.87 hours 1compartment NA NA Human Human +DTXSID7027540 Css NA 0.09333 mg/L 3compartmentss NA 50% Human Human +DTXSID7027540 Css NA 0.6903 mg/L 3compartmentss NA 95% Human Human +DTXSID7027540 Css NA 0.06782 mg/L PBTK NA 50% Human Human +DTXSID7027540 Css NA 0.4653 mg/L PBTK NA 95% Human Human +DTXSID7027540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027540 Fup 0.235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027540 Vd NA 0.9891 L/kg 1compartment NA NA Rat Human DTXSID7027540 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027540 TK.Half.Life NA 2.067 hours 1compartment NA NA Rat Human -DTXSID7027540 Css NA 0.2421 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027540 Css NA 0.9837 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027540 Css NA 0.1596 mg/L PBTK NA 50% Rat Human -DTXSID7027540 Css NA 0.5923 mg/L PBTK NA 95% Rat Human -DTXSID7027542 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027542 Fup NA 0.0541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027542 Vd NA 0.2462 L/kg 1compartment NA NA Human Human -DTXSID7027542 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7027542 TK.Half.Life NA 29.45 hours 1compartment NA NA Human Human -DTXSID7027542 Css NA 20.17 mg/L 3compartmentss NA 50% Human Human -DTXSID7027542 Css NA 91.36 mg/L 3compartmentss NA 95% Human Human -DTXSID7027542 Css NA 12.14 mg/L PBTK NA 50% Human Human -DTXSID7027542 Css NA 53.52 mg/L PBTK NA 95% Human Human -DTXSID7027542 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027542 Fup NA 0.0541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027542 Vd NA 0.2455 L/kg 1compartment NA NA Rat Human -DTXSID7027542 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7027542 TK.Half.Life NA 10 hours 1compartment NA NA Rat Human -DTXSID7027542 Css NA 5.638 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027542 Css NA 22.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027542 Css NA 3.165 mg/L PBTK NA 50% Rat Human -DTXSID7027542 Css NA 12.4 mg/L PBTK NA 95% Rat Human -DTXSID7027544 Clint NA 0.02858 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027544 Fup NA 0.4417 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027544 Vd NA 0.4171 L/kg 1compartment NA NA Human Human +DTXSID7027540 TK.Half.Life NA 0.7852 hours 1compartment NA NA Rat Human +DTXSID7027540 Css NA 0.01203 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027540 Css NA 0.06395 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027540 Css NA 0.008622 mg/L PBTK NA 50% Rat Human +DTXSID7027540 Css NA 0.04362 mg/L PBTK NA 95% Rat Human +DTXSID7027542 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027542 Fup 0.0715 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027542 Vd NA 0.2224 L/kg 1compartment NA NA Human Human +DTXSID7027542 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7027542 TK.Half.Life NA 1.257 hours 1compartment NA NA Human Human +DTXSID7027542 Css NA 0.6909 mg/L 3compartmentss NA 50% Human Human +DTXSID7027542 Css NA 4.865 mg/L 3compartmentss NA 95% Human Human +DTXSID7027542 Css NA 0.4147 mg/L PBTK NA 50% Human Human +DTXSID7027542 Css NA 2.855 mg/L PBTK NA 95% Human Human +DTXSID7027542 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027542 Fup 0.0715 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027542 Vd NA 0.2278 L/kg 1compartment NA NA Rat Human +DTXSID7027542 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7027542 TK.Half.Life NA 0.8039 hours 1compartment NA NA Rat Human +DTXSID7027542 Css NA 0.0253 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027542 Css NA 0.1912 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027542 Css NA 0.01436 mg/L PBTK NA 50% Rat Human +DTXSID7027542 Css NA 0.1079 mg/L PBTK NA 95% Rat Human +DTXSID7027544 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027544 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027544 Vd NA 0.4957 L/kg 1compartment NA NA Human Human DTXSID7027544 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027544 TK.Half.Life NA 5.83 hours 1compartment NA NA Human Human -DTXSID7027544 Css NA 1.602 mg/L 3compartmentss NA 50% Human Human -DTXSID7027544 Css NA 7.549 mg/L 3compartmentss NA 95% Human Human -DTXSID7027544 Css NA 1.146 mg/L PBTK NA 50% Human Human -DTXSID7027544 Css NA 4.641 mg/L PBTK NA 95% Human Human -DTXSID7027544 Clint NA 0.02858 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027544 Fup NA 0.4417 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027544 Vd NA 0.4236 L/kg 1compartment NA NA Rat Human +DTXSID7027544 TK.Half.Life NA 5.208 hours 1compartment NA NA Human Human +DTXSID7027544 Css NA 1.064 mg/L 3compartmentss NA 50% Human Human +DTXSID7027544 Css NA 7.206 mg/L 3compartmentss NA 95% Human Human +DTXSID7027544 Css NA 0.812 mg/L PBTK NA 50% Human Human +DTXSID7027544 Css NA 4.481 mg/L PBTK NA 95% Human Human +DTXSID7027544 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027544 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027544 Vd NA 0.5047 L/kg 1compartment NA NA Rat Human DTXSID7027544 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027544 TK.Half.Life NA 2.066 hours 1compartment NA NA Rat Human -DTXSID7027544 Css NA 0.4585 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027544 Css NA 1.861 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027544 Css NA 0.311 mg/L PBTK NA 50% Rat Human -DTXSID7027544 Css NA 1.079 mg/L PBTK NA 95% Rat Human -DTXSID7027594 Clint NA 104.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027594 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027594 Vd NA 0.2043 L/kg 1compartment NA NA Human Human +DTXSID7027544 TK.Half.Life NA 1.806 hours 1compartment NA NA Rat Human +DTXSID7027544 Css NA 0.02092 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027544 Css NA 0.1708 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027544 Css NA 0.01515 mg/L PBTK NA 50% Rat Human +DTXSID7027544 Css NA 0.105 mg/L PBTK NA 95% Rat Human +DTXSID7027594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027594 Fup 0.0584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027594 Vd NA 0.245 L/kg 1compartment NA NA Human Human DTXSID7027594 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027594 TK.Half.Life NA 1.262 hours 1compartment NA NA Human Human -DTXSID7027594 Css NA 1.026 mg/L 3compartmentss NA 50% Human Human -DTXSID7027594 Css NA 10.07 mg/L 3compartmentss NA 95% Human Human -DTXSID7027594 Css NA 0.6045 mg/L PBTK NA 50% Human Human -DTXSID7027594 Css NA 5.887 mg/L PBTK NA 95% Human Human -DTXSID7027594 Clint NA 104.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027594 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027594 Vd NA 0.1985 L/kg 1compartment NA NA Rat Human +DTXSID7027594 TK.Half.Life NA 0.9342 hours 1compartment NA NA Human Human +DTXSID7027594 Css NA 0.2762 mg/L 3compartmentss NA 50% Human Human +DTXSID7027594 Css NA 2.423 mg/L 3compartmentss NA 95% Human Human +DTXSID7027594 Css NA 0.1662 mg/L PBTK NA 50% Human Human +DTXSID7027594 Css NA 1.447 mg/L PBTK NA 95% Human Human +DTXSID7027594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027594 Fup 0.0584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027594 Vd NA 0.245 L/kg 1compartment NA NA Rat Human DTXSID7027594 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027594 TK.Half.Life NA 0.8055 hours 1compartment NA NA Rat Human -DTXSID7027594 Css NA 0.5871 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027594 Css NA 5.158 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027594 Css NA 0.321 mg/L PBTK NA 50% Rat Human -DTXSID7027594 Css NA 2.809 mg/L PBTK NA 95% Rat Human +DTXSID7027594 TK.Half.Life NA 0.5796 hours 1compartment NA NA Rat Human +DTXSID7027594 Css NA 0.002956 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027594 Css NA 0.02324 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027594 Css NA 0.001674 mg/L PBTK NA 50% Rat Human +DTXSID7027594 Css NA 0.01284 mg/L PBTK NA 95% Rat Human DTXSID7027596 Clint NA 0.9083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7027596 Fup NA 0.809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027596 Vd NA 1.876 L/kg 1compartment NA NA Human Human +DTXSID7027596 Vd NA 1.637 L/kg 1compartment NA NA Human Human DTXSID7027596 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027596 TK.Half.Life NA 6.319 hours 1compartment NA NA Human Human -DTXSID7027596 Css NA 0.3227 mg/L 3compartmentss NA 50% Human Human -DTXSID7027596 Css NA 2.315 mg/L 3compartmentss NA 95% Human Human -DTXSID7027596 Css NA 0.3278 mg/L PBTK NA 50% Human Human -DTXSID7027596 Css NA 1.635 mg/L PBTK NA 95% Human Human +DTXSID7027596 TK.Half.Life NA 5.527 hours 1compartment NA NA Human Human +DTXSID7027596 Css NA 0.2864 mg/L 3compartmentss NA 50% Human Human +DTXSID7027596 Css NA 2.053 mg/L 3compartmentss NA 95% Human Human +DTXSID7027596 Css NA 0.279 mg/L PBTK NA 50% Human Human +DTXSID7027596 Css NA 1.431 mg/L PBTK NA 95% Human Human DTXSID7027596 Clint NA 0.9083 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7027596 Fup NA 0.809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027596 Vd NA 1.885 L/kg 1compartment NA NA Rat Human +DTXSID7027596 Vd NA 1.65 L/kg 1compartment NA NA Rat Human DTXSID7027596 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027596 TK.Half.Life NA 3.041 hours 1compartment NA NA Rat Human -DTXSID7027596 Css NA 0.1193 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027596 Css NA 0.8381 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027596 Css NA 0.1206 mg/L PBTK NA 50% Rat Human -DTXSID7027596 Css NA 0.5381 mg/L PBTK NA 95% Rat Human -DTXSID7027625 Clint NA 41.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027625 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027625 Vd NA 41.56 L/kg 1compartment NA NA Human Human -DTXSID7027625 Days.Css NA 152 Days PBTK NA NA Human Human -DTXSID7027625 TK.Half.Life NA 660.1 hours 1compartment NA NA Human Human -DTXSID7027625 Css NA 0.2911 mg/L 3compartmentss NA 50% Human Human -DTXSID7027625 Css NA 1.688 mg/L 3compartmentss NA 95% Human Human -DTXSID7027625 Css NA 1.311 mg/L PBTK NA 50% Human Human -DTXSID7027625 Css NA 7.104 mg/L PBTK NA 95% Human Human -DTXSID7027625 Clint NA 41.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027625 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027625 Vd NA 34.78 L/kg 1compartment NA NA Rat Human -DTXSID7027625 Days.Css NA 96 Days PBTK NA NA Rat Human -DTXSID7027625 TK.Half.Life NA 100.1 hours 1compartment NA NA Rat Human -DTXSID7027625 Css NA 0.1515 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027625 Css NA 0.6728 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027625 Css NA 0.7158 mg/L PBTK NA 50% Rat Human -DTXSID7027625 Css NA 3.136 mg/L PBTK NA 95% Rat Human -DTXSID7027756 Clint NA 57.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027756 Fup NA 0.0691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027756 Vd NA 1.567 L/kg 1compartment NA NA Human Human +DTXSID7027596 TK.Half.Life NA 2.666 hours 1compartment NA NA Rat Human +DTXSID7027596 Css NA 0.007699 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027596 Css NA 0.06868 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027596 Css NA 0.007309 mg/L PBTK NA 50% Rat Human +DTXSID7027596 Css NA 0.04876 mg/L PBTK NA 95% Rat Human +DTXSID7027625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027625 Fup 0.0105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027625 Vd NA 135.1 L/kg 1compartment NA NA Human Human +DTXSID7027625 Days.Css NA 1057 Days PBTK NA NA Human Human +DTXSID7027625 TK.Half.Life NA 3993 hours 1compartment NA NA Human Human +DTXSID7027625 Css NA 0.1405 mg/L 3compartmentss NA 50% Human Human +DTXSID7027625 Css NA 0.8847 mg/L 3compartmentss NA 95% Human Human +DTXSID7027625 Css NA 2.389 mg/L PBTK NA 50% Human Human +DTXSID7027625 Css NA 13.95 mg/L PBTK NA 95% Human Human +DTXSID7027625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027625 Fup 0.0105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027625 Vd NA 117.9 L/kg 1compartment NA NA Rat Human +DTXSID7027625 Days.Css NA 665 Days PBTK NA NA Rat Human +DTXSID7027625 TK.Half.Life NA 607.5 hours 1compartment NA NA Rat Human +DTXSID7027625 Css NA 0.01648 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027625 Css NA 0.07936 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027625 Css NA 0.312 mg/L PBTK NA 50% Rat Human +DTXSID7027625 Css NA 1.52 mg/L PBTK NA 95% Rat Human +DTXSID7027756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027756 Fup 0.0383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027756 Vd NA 1.023 L/kg 1compartment NA NA Human Human DTXSID7027756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027756 TK.Half.Life NA 3.096 hours 1compartment NA NA Human Human -DTXSID7027756 Css NA 0.168 mg/L 3compartmentss NA 50% Human Human -DTXSID7027756 Css NA 1.241 mg/L 3compartmentss NA 95% Human Human -DTXSID7027756 Css NA 0.1098 mg/L PBTK NA 50% Human Human -DTXSID7027756 Css NA 0.7768 mg/L PBTK NA 95% Human Human -DTXSID7027756 Clint NA 57.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027756 Fup NA 0.0691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027756 Vd NA 1.185 L/kg 1compartment NA NA Rat Human +DTXSID7027756 TK.Half.Life NA 5.462 hours 1compartment NA NA Human Human +DTXSID7027756 Css NA 0.7962 mg/L 3compartmentss NA 50% Human Human +DTXSID7027756 Css NA 7.371 mg/L 3compartmentss NA 95% Human Human +DTXSID7027756 Css NA 0.4947 mg/L PBTK NA 50% Human Human +DTXSID7027756 Css NA 4.402 mg/L PBTK NA 95% Human Human +DTXSID7027756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027756 Fup 0.0383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027756 Vd NA 0.774 L/kg 1compartment NA NA Rat Human DTXSID7027756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027756 TK.Half.Life NA 1.142 hours 1compartment NA NA Rat Human -DTXSID7027756 Css NA 0.09713 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027756 Css NA 0.5339 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027756 Css NA 0.06012 mg/L PBTK NA 50% Rat Human -DTXSID7027756 Css NA 0.3243 mg/L PBTK NA 95% Rat Human -DTXSID7027833 Clint NA 2.898 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027833 Fup NA 0.3175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027833 Vd NA 1.684 L/kg 1compartment NA NA Human Human +DTXSID7027756 TK.Half.Life NA 2.384 hours 1compartment NA NA Rat Human +DTXSID7027756 Css NA 0.1043 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027756 Css NA 0.7445 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027756 Css NA 0.06247 mg/L PBTK NA 50% Rat Human +DTXSID7027756 Css NA 0.4309 mg/L PBTK NA 95% Rat Human +DTXSID7027833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027833 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027833 Vd NA 1.338 L/kg 1compartment NA NA Human Human DTXSID7027833 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027833 TK.Half.Life NA 8.471 hours 1compartment NA NA Human Human -DTXSID7027833 Css NA 0.5144 mg/L 3compartmentss NA 50% Human Human -DTXSID7027833 Css NA 2.522 mg/L 3compartmentss NA 95% Human Human -DTXSID7027833 Css NA 0.3976 mg/L PBTK NA 50% Human Human -DTXSID7027833 Css NA 1.752 mg/L PBTK NA 95% Human Human -DTXSID7027833 Clint NA 2.898 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027833 Fup NA 0.3175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027833 Vd NA 1.349 L/kg 1compartment NA NA Rat Human +DTXSID7027833 TK.Half.Life NA 2.062 hours 1compartment NA NA Human Human +DTXSID7027833 Css NA 0.09536 mg/L 3compartmentss NA 50% Human Human +DTXSID7027833 Css NA 0.6806 mg/L 3compartmentss NA 95% Human Human +DTXSID7027833 Css NA 0.06926 mg/L PBTK NA 50% Human Human +DTXSID7027833 Css NA 0.4509 mg/L PBTK NA 95% Human Human +DTXSID7027833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027833 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027833 Vd NA 1.08 L/kg 1compartment NA NA Rat Human DTXSID7027833 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027833 TK.Half.Life NA 3.093 hours 1compartment NA NA Rat Human -DTXSID7027833 Css NA 0.2435 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027833 Css NA 0.8986 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027833 Css NA 0.18 mg/L PBTK NA 50% Rat Human -DTXSID7027833 Css NA 0.5764 mg/L PBTK NA 95% Rat Human -DTXSID7027835 Clint NA 0.1054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027835 Fup NA 0.4084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027835 Vd NA 0.4686 L/kg 1compartment NA NA Human Human +DTXSID7027833 TK.Half.Life NA 0.8421 hours 1compartment NA NA Rat Human +DTXSID7027833 Css NA 0.01189 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027833 Css NA 0.06271 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027833 Css NA 0.00868 mg/L PBTK NA 50% Rat Human +DTXSID7027833 Css NA 0.04314 mg/L PBTK NA 95% Rat Human +DTXSID7027835 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027835 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7027835 Vd NA 0.3892 L/kg 1compartment NA NA Human Human DTXSID7027835 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027835 TK.Half.Life NA 6.324 hours 1compartment NA NA Human Human -DTXSID7027835 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human -DTXSID7027835 Css NA 6.933 mg/L 3compartmentss NA 95% Human Human -DTXSID7027835 Css NA 1.089 mg/L PBTK NA 50% Human Human -DTXSID7027835 Css NA 4.333 mg/L PBTK NA 95% Human Human -DTXSID7027835 Clint NA 0.1054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027835 Fup NA 0.4084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027835 Vd NA 0.4707 L/kg 1compartment NA NA Rat Human +DTXSID7027835 TK.Half.Life NA 5.336 hours 1compartment NA NA Human Human +DTXSID7027835 Css NA 1.383 mg/L 3compartmentss NA 50% Human Human +DTXSID7027835 Css NA 6.39 mg/L 3compartmentss NA 95% Human Human +DTXSID7027835 Css NA 0.9732 mg/L PBTK NA 50% Human Human +DTXSID7027835 Css NA 3.95 mg/L PBTK NA 95% Human Human +DTXSID7027835 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027835 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7027835 Vd NA 0.4022 L/kg 1compartment NA NA Rat Human DTXSID7027835 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027835 TK.Half.Life NA 2.343 hours 1compartment NA NA Rat Human -DTXSID7027835 Css NA 0.4484 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027835 Css NA 1.795 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027835 Css NA 0.3133 mg/L PBTK NA 50% Rat Human -DTXSID7027835 Css NA 1.053 mg/L PBTK NA 95% Rat Human -DTXSID7027837 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027837 Fup NA 0.6633 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027837 Vd NA 0.7708 L/kg 1compartment NA NA Human Human -DTXSID7027837 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027837 TK.Half.Life NA 7.572 hours 1compartment NA NA Human Human -DTXSID7027837 Css NA 1.132 mg/L 3compartmentss NA 50% Human Human -DTXSID7027837 Css NA 7.435 mg/L 3compartmentss NA 95% Human Human -DTXSID7027837 Css NA 0.9258 mg/L PBTK NA 50% Human Human -DTXSID7027837 Css NA 4.765 mg/L PBTK NA 95% Human Human -DTXSID7027837 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027837 Fup NA 0.6633 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027837 Vd NA 0.7728 L/kg 1compartment NA NA Rat Human -DTXSID7027837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027837 TK.Half.Life NA 2.573 hours 1compartment NA NA Rat Human -DTXSID7027837 Css NA 0.2944 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027837 Css NA 1.836 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027837 Css NA 0.2324 mg/L PBTK NA 50% Rat Human -DTXSID7027837 Css NA 1.089 mg/L PBTK NA 95% Rat Human +DTXSID7027835 TK.Half.Life NA 1.878 hours 1compartment NA NA Rat Human +DTXSID7027835 Css NA 0.02568 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027835 Css NA 0.1701 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027835 Css NA 0.01747 mg/L PBTK NA 50% Rat Human +DTXSID7027835 Css NA 0.1046 mg/L PBTK NA 95% Rat Human DTXSID7027887 Clint NA 69.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7027887 Fup NA 0.004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027887 Vd NA 41.2 L/kg 1compartment NA NA Human Human -DTXSID7027887 Days.Css NA 83 Days PBTK NA NA Human Human -DTXSID7027887 TK.Half.Life NA 392.9 hours 1compartment NA NA Human Human -DTXSID7027887 Css NA 0.1755 mg/L 3compartmentss NA 50% Human Human -DTXSID7027887 Css NA 1.067 mg/L 3compartmentss NA 95% Human Human -DTXSID7027887 Css NA 0.785 mg/L PBTK NA 50% Human Human -DTXSID7027887 Css NA 4.456 mg/L PBTK NA 95% Human Human +DTXSID7027887 Vd NA 9122 L/kg 1compartment NA NA Human Human +DTXSID7027887 Days.Css NA 8526 Days PBTK NA NA Human Human +DTXSID7027887 TK.Half.Life NA 85950 hours 1compartment NA NA Human Human +DTXSID7027887 Css NA 0.0003874 mg/L 3compartmentss NA 50% Human Human +DTXSID7027887 Css NA 0.002453 mg/L 3compartmentss NA 95% Human Human +DTXSID7027887 Css NA 0.6575 mg/L PBTK NA 50% Human Human +DTXSID7027887 Css NA 3.795 mg/L PBTK NA 95% Human Human DTXSID7027887 Clint NA 69.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7027887 Fup NA 0.004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027887 Vd NA 34.46 L/kg 1compartment NA NA Rat Human -DTXSID7027887 Days.Css NA 54 Days PBTK NA NA Rat Human -DTXSID7027887 TK.Half.Life NA 61.83 hours 1compartment NA NA Rat Human -DTXSID7027887 Css NA 0.09084 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027887 Css NA 0.3897 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027887 Css NA 0.4227 mg/L PBTK NA 50% Rat Human -DTXSID7027887 Css NA 1.873 mg/L PBTK NA 95% Rat Human -DTXSID7027916 Clint NA 0.5553 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027916 Fup NA 0.1003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027916 Vd NA 0.4972 L/kg 1compartment NA NA Human Human -DTXSID7027916 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7027916 TK.Half.Life NA 16.84 hours 1compartment NA NA Human Human -DTXSID7027916 Css NA 4.908 mg/L 3compartmentss NA 50% Human Human -DTXSID7027916 Css NA 26.06 mg/L 3compartmentss NA 95% Human Human -DTXSID7027916 Css NA 3.218 mg/L PBTK NA 50% Human Human -DTXSID7027916 Css NA 15.42 mg/L PBTK NA 95% Human Human -DTXSID7027916 Clint NA 0.5553 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027916 Fup NA 0.1003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027916 Vd NA 0.4466 L/kg 1compartment NA NA Rat Human -DTXSID7027916 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027916 TK.Half.Life NA 6.769 hours 1compartment NA NA Rat Human -DTXSID7027916 Css NA 1.888 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027916 Css NA 8.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027916 Css NA 1.158 mg/L PBTK NA 50% Rat Human -DTXSID7027916 Css NA 4.527 mg/L PBTK NA 95% Rat Human +DTXSID7027887 Vd NA 8578 L/kg 1compartment NA NA Rat Human +DTXSID7027887 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID7027887 TK.Half.Life NA 14950 hours 1compartment NA NA Rat Human +DTXSID7027887 Css NA 1.288e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027887 Css NA 9.481e-05 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027887 Css NA 0.02422 mg/L PBTK NA 50% Rat Human +DTXSID7027887 Css NA 0.1606 mg/L PBTK NA 95% Rat Human DTXSID7027966 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7027966 Fup NA 0.6939 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7027966 Vd NA 0.3872 L/kg 1compartment NA NA Human Human +DTXSID7027966 Vd NA 0.3946 L/kg 1compartment NA NA Human Human DTXSID7027966 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7027966 TK.Half.Life NA 3.61 hours 1compartment NA NA Human Human -DTXSID7027966 Css NA 1.249 mg/L 3compartmentss NA 50% Human Human -DTXSID7027966 Css NA 7.323 mg/L 3compartmentss NA 95% Human Human -DTXSID7027966 Css NA 0.8864 mg/L PBTK NA 50% Human Human -DTXSID7027966 Css NA 4.488 mg/L PBTK NA 95% Human Human +DTXSID7027966 TK.Half.Life NA 3.679 hours 1compartment NA NA Human Human +DTXSID7027966 Css NA 1.044 mg/L 3compartmentss NA 50% Human Human +DTXSID7027966 Css NA 6.504 mg/L 3compartmentss NA 95% Human Human +DTXSID7027966 Css NA 0.7456 mg/L PBTK NA 50% Human Human +DTXSID7027966 Css NA 3.97 mg/L PBTK NA 95% Human Human DTXSID7027966 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7027966 Fup NA 0.6939 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7027966 Vd NA 0.4125 L/kg 1compartment NA NA Rat Human +DTXSID7027966 Vd NA 0.4186 L/kg 1compartment NA NA Rat Human DTXSID7027966 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7027966 TK.Half.Life NA 1.311 hours 1compartment NA NA Rat Human -DTXSID7027966 Css NA 0.3315 mg/L 3compartmentss NA 50% Rat Human -DTXSID7027966 Css NA 1.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID7027966 Css NA 0.2239 mg/L PBTK NA 50% Rat Human -DTXSID7027966 Css NA 1.074 mg/L PBTK NA 95% Rat Human -DTXSID7028011 Clint NA 1820 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028011 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028011 Vd NA 1704 L/kg 1compartment NA NA Human Human -DTXSID7028011 Days.Css NA 136 Days PBTK NA NA Human Human -DTXSID7028011 TK.Half.Life NA 620.5 hours 1compartment NA NA Human Human -DTXSID7028011 Css NA 0.0001074 mg/L 3compartmentss NA 50% Human Human -DTXSID7028011 Css NA 0.0006601 mg/L 3compartmentss NA 95% Human Human -DTXSID7028011 Css NA 0.03046 mg/L PBTK NA 50% Human Human -DTXSID7028011 Css NA 0.1702 mg/L PBTK NA 95% Human Human -DTXSID7028011 Clint NA 1820 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028011 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028011 Vd NA 1574 L/kg 1compartment NA NA Rat Human -DTXSID7028011 Days.Css NA 101 Days PBTK NA NA Rat Human -DTXSID7028011 TK.Half.Life NA 108.9 hours 1compartment NA NA Rat Human -DTXSID7028011 Css NA 5.442e-05 mg/L 3compartmentss NA 50% Rat Human -DTXSID7028011 Css NA 0.0002328 mg/L 3compartmentss NA 95% Rat Human -DTXSID7028011 Css NA 0.01637 mg/L PBTK NA 50% Rat Human -DTXSID7028011 Css NA 0.06812 mg/L PBTK NA 95% Rat Human -DTXSID7028013 Clint NA 193.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028013 Fup NA 0.5367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028013 Vd NA 0.8731 L/kg 1compartment NA NA Human Human +DTXSID7027966 TK.Half.Life NA 1.33 hours 1compartment NA NA Rat Human +DTXSID7027966 Css NA 0.02022 mg/L 3compartmentss NA 50% Rat Human +DTXSID7027966 Css NA 0.1593 mg/L 3compartmentss NA 95% Rat Human +DTXSID7027966 Css NA 0.01383 mg/L PBTK NA 50% Rat Human +DTXSID7027966 Css NA 0.09519 mg/L PBTK NA 95% Rat Human +DTXSID7028013 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7028013 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7028013 Vd NA 0.5327 L/kg 1compartment NA NA Human Human DTXSID7028013 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7028013 TK.Half.Life NA 0.5981 hours 1compartment NA NA Human Human -DTXSID7028013 Css NA 0.004517 mg/L 3compartmentss NA 50% Human Human -DTXSID7028013 Css NA 0.04671 mg/L 3compartmentss NA 95% Human Human -DTXSID7028013 Css NA 0.003612 mg/L PBTK NA 50% Human Human -DTXSID7028013 Css NA 0.03194 mg/L PBTK NA 95% Human Human -DTXSID7028013 Clint NA 193.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028013 Fup NA 0.5367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028013 Vd NA 0.8287 L/kg 1compartment NA NA Rat Human +DTXSID7028013 TK.Half.Life NA 0.7345 hours 1compartment NA NA Human Human +DTXSID7028013 Css NA 0.07593 mg/L 3compartmentss NA 50% Human Human +DTXSID7028013 Css NA 0.5388 mg/L 3compartmentss NA 95% Human Human +DTXSID7028013 Css NA 0.05286 mg/L PBTK NA 50% Human Human +DTXSID7028013 Css NA 0.3552 mg/L PBTK NA 95% Human Human +DTXSID7028013 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7028013 Fup 0.277 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7028013 Vd NA 0.5165 L/kg 1compartment NA NA Rat Human DTXSID7028013 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7028013 TK.Half.Life NA 0.2514 hours 1compartment NA NA Rat Human -DTXSID7028013 Css NA 0.002397 mg/L 3compartmentss NA 50% Rat Human -DTXSID7028013 Css NA 0.02084 mg/L 3compartmentss NA 95% Rat Human -DTXSID7028013 Css NA 0.00187 mg/L PBTK NA 50% Rat Human -DTXSID7028013 Css NA 0.01388 mg/L PBTK NA 95% Rat Human -DTXSID7028015 Clint NA 9.762 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028015 Fup NA 0.2365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028015 Vd NA 1.394 L/kg 1compartment NA NA Human Human +DTXSID7028013 TK.Half.Life NA 0.3804 hours 1compartment NA NA Rat Human +DTXSID7028013 Css NA 0.009504 mg/L 3compartmentss NA 50% Rat Human +DTXSID7028013 Css NA 0.05317 mg/L 3compartmentss NA 95% Rat Human +DTXSID7028013 Css NA 0.006561 mg/L PBTK NA 50% Rat Human +DTXSID7028013 Css NA 0.0343 mg/L PBTK NA 95% Rat Human +DTXSID7028015 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7028015 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7028015 Vd NA 1.614 L/kg 1compartment NA NA Human Human DTXSID7028015 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7028015 TK.Half.Life NA 3.511 hours 1compartment NA NA Human Human -DTXSID7028015 Css NA 0.2192 mg/L 3compartmentss NA 50% Human Human -DTXSID7028015 Css NA 1.369 mg/L 3compartmentss NA 95% Human Human -DTXSID7028015 Css NA 0.1612 mg/L PBTK NA 50% Human Human -DTXSID7028015 Css NA 0.9279 mg/L PBTK NA 95% Human Human -DTXSID7028015 Clint NA 9.762 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028015 Fup NA 0.2365 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028015 Vd NA 1.118 L/kg 1compartment NA NA Rat Human +DTXSID7028015 TK.Half.Life NA 1.938 hours 1compartment NA NA Human Human +DTXSID7028015 Css NA 0.059 mg/L 3compartmentss NA 50% Human Human +DTXSID7028015 Css NA 0.4343 mg/L 3compartmentss NA 95% Human Human +DTXSID7028015 Css NA 0.04641 mg/L PBTK NA 50% Human Human +DTXSID7028015 Css NA 0.3173 mg/L PBTK NA 95% Human Human +DTXSID7028015 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7028015 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7028015 Vd NA 1.318 L/kg 1compartment NA NA Rat Human DTXSID7028015 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7028015 TK.Half.Life NA 1.451 hours 1compartment NA NA Rat Human -DTXSID7028015 Css NA 0.1182 mg/L 3compartmentss NA 50% Rat Human -DTXSID7028015 Css NA 0.53 mg/L 3compartmentss NA 95% Rat Human -DTXSID7028015 Css NA 0.08232 mg/L PBTK NA 50% Rat Human -DTXSID7028015 Css NA 0.3387 mg/L PBTK NA 95% Rat Human -DTXSID7028300 Clint NA 34.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028300 Fup NA 0.0575 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028300 Vd NA 2.647 L/kg 1compartment NA NA Human Human -DTXSID7028300 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7028300 TK.Half.Life NA 13.09 hours 1compartment NA NA Human Human -DTXSID7028300 Css NA 0.5831 mg/L 3compartmentss NA 50% Human Human -DTXSID7028300 Css NA 4.104 mg/L 3compartmentss NA 95% Human Human -DTXSID7028300 Css NA 0.397 mg/L PBTK NA 50% Human Human -DTXSID7028300 Css NA 2.677 mg/L PBTK NA 95% Human Human -DTXSID7028300 Clint NA 34.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028300 Fup NA 0.0575 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028300 Vd NA 1.985 L/kg 1compartment NA NA Rat Human -DTXSID7028300 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7028300 TK.Half.Life NA 3.107 hours 1compartment NA NA Rat Human -DTXSID7028300 Css NA 0.3248 mg/L 3compartmentss NA 50% Rat Human -DTXSID7028300 Css NA 1.765 mg/L 3compartmentss NA 95% Rat Human -DTXSID7028300 Css NA 0.2103 mg/L PBTK NA 50% Rat Human -DTXSID7028300 Css NA 1.081 mg/L PBTK NA 95% Rat Human -DTXSID7028306 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028306 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028306 Vd NA 7.421 L/kg 1compartment NA NA Human Human -DTXSID7028306 Days.Css NA 2287 Days PBTK NA NA Human Human -DTXSID7028306 TK.Half.Life NA 8383 hours 1compartment NA NA Human Human -DTXSID7028306 Css NA 116.9 mg/L 3compartmentss NA 50% Human Human -DTXSID7028306 Css NA 858.7 mg/L 3compartmentss NA 95% Human Human -DTXSID7028306 Css NA 111 mg/L PBTK NA 50% Human Human -DTXSID7028306 Css NA 572.8 mg/L PBTK NA 95% Human Human -DTXSID7028306 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028306 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028306 Vd NA 5.784 L/kg 1compartment NA NA Rat Human -DTXSID7028306 Days.Css NA 606 Days PBTK NA NA Rat Human -DTXSID7028306 TK.Half.Life NA 1808 hours 1compartment NA NA Rat Human -DTXSID7028306 Css NA 31.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID7028306 Css NA 207.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID7028306 Css NA 29.17 mg/L PBTK NA 50% Rat Human -DTXSID7028306 Css NA 130.3 mg/L PBTK NA 95% Rat Human -DTXSID7028774 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028774 Fup NA 0.04 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028774 Vd NA 3.13 L/kg 1compartment NA NA Human Human -DTXSID7028774 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID7028774 TK.Half.Life NA 110100 hours 1compartment NA NA Human Human -DTXSID7028774 Css NA 3985 mg/L 3compartmentss NA 50% Human Human -DTXSID7028774 Css NA 9782 mg/L 3compartmentss NA 95% Human Human -DTXSID7028774 Css NA 2776 mg/L PBTK NA 50% Human Human -DTXSID7028774 Css NA 6414 mg/L PBTK NA 95% Human Human -DTXSID7028774 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028774 Fup NA 0.04 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028774 Vd NA 2.345 L/kg 1compartment NA NA Rat Human -DTXSID7028774 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID7028774 TK.Half.Life NA 6796 hours 1compartment NA NA Rat Human -DTXSID7028774 Css NA 1085 mg/L 3compartmentss NA 50% Rat Human -DTXSID7028774 Css NA 2176 mg/L 3compartmentss NA 95% Rat Human -DTXSID7028774 Css NA 723.1 mg/L PBTK NA 50% Rat Human -DTXSID7028774 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID7028776 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028776 Fup NA 0.3563 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7028776 Vd NA 2.96 L/kg 1compartment NA NA Human Human -DTXSID7028776 Days.Css NA 99 Days PBTK NA NA Human Human -DTXSID7028776 TK.Half.Life NA 430 hours 1compartment NA NA Human Human -DTXSID7028776 Css NA 15.88 mg/L 3compartmentss NA 50% Human Human -DTXSID7028776 Css NA 45.67 mg/L 3compartmentss NA 95% Human Human -DTXSID7028776 Css NA 11.71 mg/L PBTK NA 50% Human Human -DTXSID7028776 Css NA 30.51 mg/L PBTK NA 95% Human Human -DTXSID7028776 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028776 Fup NA 0.3563 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7028776 Vd NA 2.247 L/kg 1compartment NA NA Rat Human -DTXSID7028776 Days.Css NA 24 Days PBTK NA NA Rat Human -DTXSID7028776 TK.Half.Life NA 37.11 hours 1compartment NA NA Rat Human -DTXSID7028776 Css NA 4.284 mg/L 3compartmentss NA 50% Rat Human -DTXSID7028776 Css NA 9.782 mg/L 3compartmentss NA 95% Rat Human -DTXSID7028776 Css NA 3.033 mg/L PBTK NA 50% Rat Human -DTXSID7028776 Css NA 6.099 mg/L PBTK NA 95% Rat Human -DTXSID7029110 Clint NA 17.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029110 Fup NA 0.157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029110 Vd NA 2.822 L/kg 1compartment NA NA Human Human -DTXSID7029110 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7029110 TK.Half.Life NA 15.54 hours 1compartment NA NA Human Human -DTXSID7029110 Css NA 0.609 mg/L 3compartmentss NA 50% Human Human -DTXSID7029110 Css NA 3.648 mg/L 3compartmentss NA 95% Human Human -DTXSID7029110 Css NA 0.4288 mg/L PBTK NA 50% Human Human -DTXSID7029110 Css NA 2.511 mg/L PBTK NA 95% Human Human -DTXSID7029110 Clint NA 17.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029110 Fup NA 0.157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029110 Vd NA 2.129 L/kg 1compartment NA NA Rat Human -DTXSID7029110 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029110 TK.Half.Life NA 3.265 hours 1compartment NA NA Rat Human -DTXSID7029110 Css NA 0.3307 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029110 Css NA 1.64 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029110 Css NA 0.2238 mg/L PBTK NA 50% Rat Human -DTXSID7029110 Css NA 1.059 mg/L PBTK NA 95% Rat Human -DTXSID7029160 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029160 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029160 Vd NA 3.698 L/kg 1compartment NA NA Human Human -DTXSID7029160 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID7029160 TK.Half.Life NA 174500 hours 1compartment NA NA Human Human -DTXSID7029160 Css NA 4986 mg/L 3compartmentss NA 50% Human Human -DTXSID7029160 Css NA 11190 mg/L 3compartmentss NA 95% Human Human -DTXSID7029160 Css NA 3643 mg/L PBTK NA 50% Human Human -DTXSID7029160 Css NA 7843 mg/L PBTK NA 95% Human Human -DTXSID7029160 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029160 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029160 Vd NA 2.789 L/kg 1compartment NA NA Rat Human -DTXSID7029160 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID7029160 TK.Half.Life NA 10960 hours 1compartment NA NA Rat Human -DTXSID7029160 Css NA 1389 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029160 Css NA 2013 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029160 Css NA 973.8 mg/L PBTK NA 50% Rat Human -DTXSID7029160 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID7029164 Clint NA 1.054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029164 Fup NA 0.2324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029164 Vd NA 0.646 L/kg 1compartment NA NA Human Human -DTXSID7029164 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7029164 TK.Half.Life NA 6.749 hours 1compartment NA NA Human Human -DTXSID7029164 Css NA 1.119 mg/L 3compartmentss NA 50% Human Human -DTXSID7029164 Css NA 4.936 mg/L 3compartmentss NA 95% Human Human -DTXSID7029164 Css NA 0.8456 mg/L PBTK NA 50% Human Human -DTXSID7029164 Css NA 3.246 mg/L PBTK NA 95% Human Human -DTXSID7029164 Clint NA 1.054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029164 Fup NA 0.2324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029164 Vd NA 0.6421 L/kg 1compartment NA NA Rat Human +DTXSID7028015 TK.Half.Life NA 0.7569 hours 1compartment NA NA Rat Human +DTXSID7028015 Css NA 0.007231 mg/L 3compartmentss NA 50% Rat Human +DTXSID7028015 Css NA 0.04192 mg/L 3compartmentss NA 95% Rat Human +DTXSID7028015 Css NA 0.005766 mg/L PBTK NA 50% Rat Human +DTXSID7028015 Css NA 0.02973 mg/L PBTK NA 95% Rat Human +DTXSID7028300 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7028300 Fup 0.0148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7028300 Vd NA 2.167 L/kg 1compartment NA NA Human Human +DTXSID7028300 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7028300 TK.Half.Life NA 27.97 hours 1compartment NA NA Human Human +DTXSID7028300 Css NA 1.895 mg/L 3compartmentss NA 50% Human Human +DTXSID7028300 Css NA 15.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7028300 Css NA 1.217 mg/L PBTK NA 50% Human Human +DTXSID7028300 Css NA 9.461 mg/L PBTK NA 95% Human Human +DTXSID7028300 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7028300 Fup 0.0148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7028300 Vd NA 1.61 L/kg 1compartment NA NA Rat Human +DTXSID7028300 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7028300 TK.Half.Life NA 8.309 hours 1compartment NA NA Rat Human +DTXSID7028300 Css NA 0.2485 mg/L 3compartmentss NA 50% Rat Human +DTXSID7028300 Css NA 1.62 mg/L 3compartmentss NA 95% Rat Human +DTXSID7028300 Css NA 0.1572 mg/L PBTK NA 50% Rat Human +DTXSID7028300 Css NA 0.9904 mg/L PBTK NA 95% Rat Human +DTXSID7029160 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029160 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029160 Vd NA 2.993 L/kg 1compartment NA NA Human Human +DTXSID7029160 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID7029160 TK.Half.Life NA 69.9 hours 1compartment NA NA Human Human +DTXSID7029160 Css NA 2.912 mg/L 3compartmentss NA 50% Human Human +DTXSID7029160 Css NA 20.1 mg/L 3compartmentss NA 95% Human Human +DTXSID7029160 Css NA 1.989 mg/L PBTK NA 50% Human Human +DTXSID7029160 Css NA 13.32 mg/L PBTK NA 95% Human Human +DTXSID7029160 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029160 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029160 Vd NA 2.24 L/kg 1compartment NA NA Rat Human +DTXSID7029160 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID7029160 TK.Half.Life NA 11.14 hours 1compartment NA NA Rat Human +DTXSID7029160 Css NA 0.3772 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029160 Css NA 2.178 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029160 Css NA 0.2556 mg/L PBTK NA 50% Rat Human +DTXSID7029160 Css NA 1.435 mg/L PBTK NA 95% Rat Human +DTXSID7029162 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029162 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029162 Vd NA 0.8334 L/kg 1compartment NA NA Human Human +DTXSID7029162 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7029162 TK.Half.Life NA 11.14 hours 1compartment NA NA Human Human +DTXSID7029162 Css NA 1.366 mg/L 3compartmentss NA 50% Human Human +DTXSID7029162 Css NA 7.204 mg/L 3compartmentss NA 95% Human Human +DTXSID7029162 Css NA 1.096 mg/L PBTK NA 50% Human Human +DTXSID7029162 Css NA 4.66 mg/L PBTK NA 95% Human Human +DTXSID7029162 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029162 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029162 Vd NA 0.7904 L/kg 1compartment NA NA Rat Human +DTXSID7029162 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7029162 TK.Half.Life NA 3.535 hours 1compartment NA NA Rat Human +DTXSID7029162 Css NA 0.08677 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029162 Css NA 0.4018 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029162 Css NA 0.06892 mg/L PBTK NA 50% Rat Human +DTXSID7029162 Css NA 0.2508 mg/L PBTK NA 95% Rat Human +DTXSID7029164 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029164 Fup 0.428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029164 Vd NA 0.8031 L/kg 1compartment NA NA Human Human +DTXSID7029164 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7029164 TK.Half.Life NA 12.14 hours 1compartment NA NA Human Human +DTXSID7029164 Css NA 0.7916 mg/L 3compartmentss NA 50% Human Human +DTXSID7029164 Css NA 4.102 mg/L 3compartmentss NA 95% Human Human +DTXSID7029164 Css NA 0.6752 mg/L PBTK NA 50% Human Human +DTXSID7029164 Css NA 2.801 mg/L PBTK NA 95% Human Human +DTXSID7029164 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029164 Fup 0.428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029164 Vd NA 0.8057 L/kg 1compartment NA NA Rat Human DTXSID7029164 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029164 TK.Half.Life NA 3.342 hours 1compartment NA NA Rat Human -DTXSID7029164 Css NA 0.4542 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029164 Css NA 1.652 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029164 Css NA 0.3298 mg/L PBTK NA 50% Rat Human -DTXSID7029164 Css NA 1.006 mg/L PBTK NA 95% Rat Human +DTXSID7029164 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human +DTXSID7029164 Css NA 0.004287 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029164 Css NA 0.0224 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029164 Css NA 0.003523 mg/L PBTK NA 50% Rat Human +DTXSID7029164 Css NA 0.01459 mg/L PBTK NA 95% Rat Human DTXSID7029166 Clint NA 3.769 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7029166 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029166 Vd NA 0.2234 L/kg 1compartment NA NA Human Human +DTXSID7029166 Vd NA 0.229 L/kg 1compartment NA NA Human Human DTXSID7029166 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7029166 TK.Half.Life NA 1.97 hours 1compartment NA NA Human Human -DTXSID7029166 Css NA 1.398 mg/L 3compartmentss NA 50% Human Human -DTXSID7029166 Css NA 8.757 mg/L 3compartmentss NA 95% Human Human -DTXSID7029166 Css NA 0.8405 mg/L PBTK NA 50% Human Human -DTXSID7029166 Css NA 5.133 mg/L PBTK NA 95% Human Human +DTXSID7029166 TK.Half.Life NA 2.057 hours 1compartment NA NA Human Human +DTXSID7029166 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human +DTXSID7029166 Css NA 8.649 mg/L 3compartmentss NA 95% Human Human +DTXSID7029166 Css NA 0.8328 mg/L PBTK NA 50% Human Human +DTXSID7029166 Css NA 5.138 mg/L PBTK NA 95% Human Human DTXSID7029166 Clint NA 3.769 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7029166 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029166 Vd NA 0.2262 L/kg 1compartment NA NA Rat Human +DTXSID7029166 Vd NA 0.231 L/kg 1compartment NA NA Rat Human DTXSID7029166 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029166 TK.Half.Life NA 1.185 hours 1compartment NA NA Rat Human -DTXSID7029166 Css NA 0.7014 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029166 Css NA 3.218 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029166 Css NA 0.3976 mg/L PBTK NA 50% Rat Human -DTXSID7029166 Css NA 1.778 mg/L PBTK NA 95% Rat Human +DTXSID7029166 TK.Half.Life NA 1.232 hours 1compartment NA NA Rat Human +DTXSID7029166 Css NA 0.1605 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029166 Css NA 0.7454 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029166 Css NA 0.09412 mg/L PBTK NA 50% Rat Human +DTXSID7029166 Css NA 0.4233 mg/L PBTK NA 95% Rat Human DTXSID7029241 Clint 128 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7029241 Fup NA 0.0096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029241 Vd NA 3.463 L/kg 1compartment NA NA Human Human -DTXSID7029241 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7029241 TK.Half.Life NA 20.12 hours 1compartment NA NA Human Human -DTXSID7029241 Css NA 0.596 mg/L 3compartmentss NA 50% Human Human -DTXSID7029241 Css NA 5.301 mg/L 3compartmentss NA 95% Human Human -DTXSID7029241 Css NA 0.4266 mg/L PBTK NA 50% Human Human -DTXSID7029241 Css NA 3.764 mg/L PBTK NA 95% Human Human +DTXSID7029241 Fup 0.00238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029241 Vd NA 4.747 L/kg 1compartment NA NA Human Human +DTXSID7029241 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7029241 TK.Half.Life NA 28.2 hours 1compartment NA NA Human Human +DTXSID7029241 Css NA 0.5523 mg/L 3compartmentss NA 50% Human Human +DTXSID7029241 Css NA 4.958 mg/L 3compartmentss NA 95% Human Human +DTXSID7029241 Css NA 0.4401 mg/L PBTK NA 50% Human Human +DTXSID7029241 Css NA 3.865 mg/L PBTK NA 95% Human Human DTXSID7029241 Clint 128 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7029241 Fup NA 0.0096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029241 Vd NA 2.604 L/kg 1compartment NA NA Rat Human +DTXSID7029241 Fup 0.00238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029241 Vd NA 3.618 L/kg 1compartment NA NA Rat Human DTXSID7029241 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7029241 TK.Half.Life NA 3.193 hours 1compartment NA NA Rat Human -DTXSID7029241 Css NA 0.3385 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029241 Css NA 2.403 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029241 Css NA 0.2329 mg/L PBTK NA 50% Rat Human -DTXSID7029241 Css NA 1.622 mg/L PBTK NA 95% Rat Human -DTXSID7029247 Clint NA 29.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029247 Fup NA 0.2042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029247 Vd NA 2.122 L/kg 1compartment NA NA Human Human +DTXSID7029241 TK.Half.Life NA 4.847 hours 1compartment NA NA Rat Human +DTXSID7029241 Css NA 0.07304 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029241 Css NA 0.5229 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029241 Css NA 0.05838 mg/L PBTK NA 50% Rat Human +DTXSID7029241 Css NA 0.419 mg/L PBTK NA 95% Rat Human +DTXSID7029247 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029247 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029247 Vd NA 1.41 L/kg 1compartment NA NA Human Human DTXSID7029247 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7029247 TK.Half.Life NA 3.721 hours 1compartment NA NA Human Human -DTXSID7029247 Css NA 0.123 mg/L 3compartmentss NA 50% Human Human -DTXSID7029247 Css NA 0.7999 mg/L 3compartmentss NA 95% Human Human -DTXSID7029247 Css NA 0.08964 mg/L PBTK NA 50% Human Human -DTXSID7029247 Css NA 0.5476 mg/L PBTK NA 95% Human Human -DTXSID7029247 Clint NA 29.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029247 Fup NA 0.2042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029247 Vd NA 1.632 L/kg 1compartment NA NA Rat Human +DTXSID7029247 TK.Half.Life NA 3.606 hours 1compartment NA NA Human Human +DTXSID7029247 Css NA 0.2168 mg/L 3compartmentss NA 50% Human Human +DTXSID7029247 Css NA 1.355 mg/L 3compartmentss NA 95% Human Human +DTXSID7029247 Css NA 0.1667 mg/L PBTK NA 50% Human Human +DTXSID7029247 Css NA 0.9365 mg/L PBTK NA 95% Human Human +DTXSID7029247 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029247 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029247 Vd NA 1.16 L/kg 1compartment NA NA Rat Human DTXSID7029247 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029247 TK.Half.Life NA 1.226 hours 1compartment NA NA Rat Human -DTXSID7029247 Css NA 0.06736 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029247 Css NA 0.3438 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029247 Css NA 0.04703 mg/L PBTK NA 50% Rat Human -DTXSID7029247 Css NA 0.2257 mg/L PBTK NA 95% Rat Human -DTXSID7029249 Clint NA 5.282 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029249 Fup NA 0.6356 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029249 Vd NA 2.031 L/kg 1compartment NA NA Human Human -DTXSID7029249 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7029249 TK.Half.Life NA 2.943 hours 1compartment NA NA Human Human -DTXSID7029249 Css NA 0.1026 mg/L 3compartmentss NA 50% Human Human -DTXSID7029249 Css NA 1.106 mg/L 3compartmentss NA 95% Human Human -DTXSID7029249 Css NA 0.103 mg/L PBTK NA 50% Human Human -DTXSID7029249 Css NA 0.7966 mg/L PBTK NA 95% Human Human -DTXSID7029249 Clint NA 5.282 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029249 Fup NA 0.6356 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029249 Vd NA 2.052 L/kg 1compartment NA NA Rat Human +DTXSID7029247 TK.Half.Life NA 1.515 hours 1compartment NA NA Rat Human +DTXSID7029247 Css NA 0.0252 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029247 Css NA 0.1136 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029247 Css NA 0.01938 mg/L PBTK NA 50% Rat Human +DTXSID7029247 Css NA 0.07625 mg/L PBTK NA 95% Rat Human +DTXSID7029249 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029249 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029249 Vd NA 0.9758 L/kg 1compartment NA NA Human Human +DTXSID7029249 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID7029249 TK.Half.Life NA 27.33 hours 1compartment NA NA Human Human +DTXSID7029249 Css NA 2.596 mg/L 3compartmentss NA 50% Human Human +DTXSID7029249 Css NA 10.42 mg/L 3compartmentss NA 95% Human Human +DTXSID7029249 Css NA 1.939 mg/L PBTK NA 50% Human Human +DTXSID7029249 Css NA 6.709 mg/L PBTK NA 95% Human Human +DTXSID7029249 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029249 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029249 Vd NA 0.9741 L/kg 1compartment NA NA Rat Human DTXSID7029249 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029249 TK.Half.Life NA 1.65 hours 1compartment NA NA Rat Human -DTXSID7029249 Css NA 0.04867 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029249 Css NA 0.424 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029249 Css NA 0.0485 mg/L PBTK NA 50% Rat Human -DTXSID7029249 Css NA 0.2809 mg/L PBTK NA 95% Rat Human -DTXSID7029299 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029299 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029299 Vd NA 41.12 L/kg 1compartment NA NA Human Human -DTXSID7029299 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID7029299 TK.Half.Life NA 1969000 hours 1compartment NA NA Human Human -DTXSID7029299 Css NA 826.2 mg/L 3compartmentss NA 50% Human Human -DTXSID7029299 Css NA 2137 mg/L 3compartmentss NA 95% Human Human -DTXSID7029299 Css NA 3697 mg/L PBTK NA 50% Human Human -DTXSID7029299 Css NA 7979 mg/L PBTK NA 95% Human Human -DTXSID7029299 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029299 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029299 Vd NA 34.4 L/kg 1compartment NA NA Rat Human -DTXSID7029299 Days.Css NA 13780 Days PBTK NA NA Rat Human -DTXSID7029299 TK.Half.Life NA 139000 hours 1compartment NA NA Rat Human -DTXSID7029299 Css NA 206.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029299 Css NA 354.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029299 Css NA 992 mg/L PBTK NA 50% Rat Human -DTXSID7029299 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID7029320 Clint NA 40.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7029249 TK.Half.Life NA 9.298 hours 1compartment NA NA Rat Human +DTXSID7029249 Css NA 0.04576 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029249 Css NA 0.2842 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029249 Css NA 0.03333 mg/L PBTK NA 50% Rat Human +DTXSID7029249 Css NA 0.1855 mg/L PBTK NA 95% Rat Human +DTXSID7029320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7029320 Fup 2.77e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7029320 Vd NA 0.2329 L/kg 1compartment NA NA Human Human -DTXSID7029320 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID7029320 TK.Half.Life NA 118 hours 1compartment NA NA Human Human -DTXSID7029320 Css NA 36.25 mg/L 3compartmentss NA 50% Human Human -DTXSID7029320 Css NA 234.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7029320 Css NA 21.19 mg/L PBTK NA 50% Human Human -DTXSID7029320 Css NA 134.8 mg/L PBTK NA 95% Human Human -DTXSID7029320 Clint NA 40.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7029320 Vd NA 3.406 L/kg 1compartment NA NA Human Human +DTXSID7029320 Days.Css NA 25 Days PBTK NA NA Human Human +DTXSID7029320 TK.Half.Life NA 138.7 hours 1compartment NA NA Human Human +DTXSID7029320 Css NA 4.131 mg/L 3compartmentss NA 50% Human Human +DTXSID7029320 Css NA 24.14 mg/L 3compartmentss NA 95% Human Human +DTXSID7029320 Css NA 2.974 mg/L PBTK NA 50% Human Human +DTXSID7029320 Css NA 17.21 mg/L PBTK NA 95% Human Human +DTXSID7029320 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7029320 Fup 2.77e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7029320 Vd NA 0.1972 L/kg 1compartment NA NA Rat Human +DTXSID7029320 Vd NA 2.56 L/kg 1compartment NA NA Rat Human DTXSID7029320 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID7029320 TK.Half.Life NA 69.56 hours 1compartment NA NA Rat Human -DTXSID7029320 Css NA 25.31 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029320 Css NA 91.95 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029320 Css NA 13.7 mg/L PBTK NA 50% Rat Human -DTXSID7029320 Css NA 49.72 mg/L PBTK NA 95% Rat Human -DTXSID7029611 Clint NA 740.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029611 Fup NA 0.0326 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029611 Vd NA 0.9757 L/kg 1compartment NA NA Human Human +DTXSID7029320 TK.Half.Life NA 72.6 hours 1compartment NA NA Rat Human +DTXSID7029320 Css NA 0.5424 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029320 Css NA 2.738 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029320 Css NA 0.3882 mg/L PBTK NA 50% Rat Human +DTXSID7029320 Css NA 1.967 mg/L PBTK NA 95% Rat Human +DTXSID70293821 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70293821 Fup 0.553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70293821 Vd NA 1.133 L/kg 1compartment NA NA Human Human +DTXSID70293821 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID70293821 TK.Half.Life NA 14.48 hours 1compartment NA NA Human Human +DTXSID70293821 Css NA 1.316 mg/L 3compartmentss NA 50% Human Human +DTXSID70293821 Css NA 8.765 mg/L 3compartmentss NA 95% Human Human +DTXSID70293821 Css NA 1.083 mg/L PBTK NA 50% Human Human +DTXSID70293821 Css NA 5.612 mg/L PBTK NA 95% Human Human +DTXSID70293821 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70293821 Fup 0.553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70293821 Vd NA 1.325 L/kg 1compartment NA NA Rat Human +DTXSID70293821 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70293821 TK.Half.Life NA 3.362 hours 1compartment NA NA Rat Human +DTXSID70293821 Css NA 0.04938 mg/L 3compartmentss NA 50% Rat Human +DTXSID70293821 Css NA 0.1869 mg/L 3compartmentss NA 95% Rat Human +DTXSID70293821 Css NA 0.04643 mg/L PBTK NA 50% Rat Human +DTXSID70293821 Css NA 0.1293 mg/L PBTK NA 95% Rat Human +DTXSID7029611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029611 Fup 0.0765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029611 Vd NA 1.999 L/kg 1compartment NA NA Human Human DTXSID7029611 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7029611 TK.Half.Life NA 1.047 hours 1compartment NA NA Human Human -DTXSID7029611 Css NA 0.0284 mg/L 3compartmentss NA 50% Human Human -DTXSID7029611 Css NA 0.2643 mg/L 3compartmentss NA 95% Human Human -DTXSID7029611 Css NA 0.01742 mg/L PBTK NA 50% Human Human -DTXSID7029611 Css NA 0.1589 mg/L PBTK NA 95% Human Human -DTXSID7029611 Clint NA 740.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029611 Fup NA 0.0326 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029611 Vd NA 0.7363 L/kg 1compartment NA NA Rat Human +DTXSID7029611 TK.Half.Life NA 8.014 hours 1compartment NA NA Human Human +DTXSID7029611 Css NA 0.4728 mg/L 3compartmentss NA 50% Human Human +DTXSID7029611 Css NA 3.244 mg/L 3compartmentss NA 95% Human Human +DTXSID7029611 Css NA 0.3173 mg/L PBTK NA 50% Human Human +DTXSID7029611 Css NA 2.058 mg/L PBTK NA 95% Human Human +DTXSID7029611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029611 Fup 0.0765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029611 Vd NA 1.507 L/kg 1compartment NA NA Rat Human DTXSID7029611 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029611 TK.Half.Life NA 0.3671 hours 1compartment NA NA Rat Human -DTXSID7029611 Css NA 0.01654 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029611 Css NA 0.1315 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029611 Css NA 0.00953 mg/L PBTK NA 50% Rat Human -DTXSID7029611 Css NA 0.07344 mg/L PBTK NA 95% Rat Human +DTXSID7029611 TK.Half.Life NA 2.64 hours 1compartment NA NA Rat Human +DTXSID7029611 Css NA 0.06115 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029611 Css NA 0.3359 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029611 Css NA 0.0402 mg/L PBTK NA 50% Rat Human +DTXSID7029611 Css NA 0.2096 mg/L PBTK NA 95% Rat Human DTXSID7029617 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7029617 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029617 Vd NA 0.5453 L/kg 1compartment NA NA Human Human +DTXSID7029617 Vd NA 0.6184 L/kg 1compartment NA NA Human Human DTXSID7029617 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7029617 TK.Half.Life NA 5.001 hours 1compartment NA NA Human Human -DTXSID7029617 Css NA 1.121 mg/L 3compartmentss NA 50% Human Human -DTXSID7029617 Css NA 7.122 mg/L 3compartmentss NA 95% Human Human -DTXSID7029617 Css NA 0.8713 mg/L PBTK NA 50% Human Human -DTXSID7029617 Css NA 4.478 mg/L PBTK NA 95% Human Human +DTXSID7029617 TK.Half.Life NA 5.672 hours 1compartment NA NA Human Human +DTXSID7029617 Css NA 0.9476 mg/L 3compartmentss NA 50% Human Human +DTXSID7029617 Css NA 6.125 mg/L 3compartmentss NA 95% Human Human +DTXSID7029617 Css NA 0.7519 mg/L PBTK NA 50% Human Human +DTXSID7029617 Css NA 3.908 mg/L PBTK NA 95% Human Human DTXSID7029617 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7029617 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029617 Vd NA 0.5854 L/kg 1compartment NA NA Rat Human +DTXSID7029617 Vd NA 0.6476 L/kg 1compartment NA NA Rat Human DTXSID7029617 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029617 TK.Half.Life NA 1.83 hours 1compartment NA NA Rat Human -DTXSID7029617 Css NA 0.2987 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029617 Css NA 1.854 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029617 Css NA 0.2218 mg/L PBTK NA 50% Rat Human -DTXSID7029617 Css NA 1.078 mg/L PBTK NA 95% Rat Human -DTXSID7029619 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029619 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029619 Vd NA 0.3458 L/kg 1compartment NA NA Human Human -DTXSID7029619 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7029619 TK.Half.Life NA 8.147 hours 1compartment NA NA Human Human -DTXSID7029619 Css NA 2.926 mg/L 3compartmentss NA 50% Human Human -DTXSID7029619 Css NA 11.09 mg/L 3compartmentss NA 95% Human Human -DTXSID7029619 Css NA 1.921 mg/L PBTK NA 50% Human Human -DTXSID7029619 Css NA 6.719 mg/L PBTK NA 95% Human Human -DTXSID7029619 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029619 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029619 Vd NA 0.3464 L/kg 1compartment NA NA Rat Human -DTXSID7029619 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029619 TK.Half.Life NA 2.779 hours 1compartment NA NA Rat Human -DTXSID7029619 Css NA 0.8088 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029619 Css NA 2.594 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029619 Css NA 0.5041 mg/L PBTK NA 50% Rat Human -DTXSID7029619 Css NA 1.474 mg/L PBTK NA 95% Rat Human -DTXSID7029665 Clint NA 31.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029665 Fup NA 0.4007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029665 Vd NA 1.178 L/kg 1compartment NA NA Human Human +DTXSID7029617 TK.Half.Life NA 2.025 hours 1compartment NA NA Rat Human +DTXSID7029617 Css NA 0.01809 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029617 Css NA 0.1443 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029617 Css NA 0.01393 mg/L PBTK NA 50% Rat Human +DTXSID7029617 Css NA 0.09074 mg/L PBTK NA 95% Rat Human +DTXSID7029665 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029665 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7029665 Vd NA 1.086 L/kg 1compartment NA NA Human Human DTXSID7029665 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7029665 TK.Half.Life NA 1.158 hours 1compartment NA NA Human Human -DTXSID7029665 Css NA 0.03614 mg/L 3compartmentss NA 50% Human Human -DTXSID7029665 Css NA 0.2871 mg/L 3compartmentss NA 95% Human Human -DTXSID7029665 Css NA 0.02847 mg/L PBTK NA 50% Human Human -DTXSID7029665 Css NA 0.2022 mg/L PBTK NA 95% Human Human -DTXSID7029665 Clint NA 31.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029665 Fup NA 0.4007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029665 Vd NA 1.014 L/kg 1compartment NA NA Rat Human +DTXSID7029665 TK.Half.Life NA 1.229 hours 1compartment NA NA Human Human +DTXSID7029665 Css NA 0.05077 mg/L 3compartmentss NA 50% Human Human +DTXSID7029665 Css NA 0.3949 mg/L 3compartmentss NA 95% Human Human +DTXSID7029665 Css NA 0.03924 mg/L PBTK NA 50% Human Human +DTXSID7029665 Css NA 0.2783 mg/L PBTK NA 95% Human Human +DTXSID7029665 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029665 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7029665 Vd NA 0.9455 L/kg 1compartment NA NA Rat Human DTXSID7029665 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029665 TK.Half.Life NA 0.4864 hours 1compartment NA NA Rat Human -DTXSID7029665 Css NA 0.01966 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029665 Css NA 0.1239 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029665 Css NA 0.01493 mg/L PBTK NA 50% Rat Human -DTXSID7029665 Css NA 0.08404 mg/L PBTK NA 95% Rat Human +DTXSID7029665 TK.Half.Life NA 0.5411 hours 1compartment NA NA Rat Human +DTXSID7029665 Css NA 0.006232 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029665 Css NA 0.03904 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029665 Css NA 0.004891 mg/L PBTK NA 50% Rat Human +DTXSID7029665 Css NA 0.02692 mg/L PBTK NA 95% Rat Human DTXSID7029871 Clint 77.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7029871 Fup 0.00953 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7029871 Vd NA 2.744 L/kg 1compartment NA NA Human Human -DTXSID7029871 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7029871 TK.Half.Life NA 17.28 hours 1compartment NA NA Human Human -DTXSID7029871 Css NA 0.6919 mg/L 3compartmentss NA 50% Human Human -DTXSID7029871 Css NA 4.235 mg/L 3compartmentss NA 95% Human Human -DTXSID7029871 Css NA 0.4698 mg/L PBTK NA 50% Human Human -DTXSID7029871 Css NA 2.791 mg/L PBTK NA 95% Human Human +DTXSID7029871 Vd NA 2.988 L/kg 1compartment NA NA Human Human +DTXSID7029871 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7029871 TK.Half.Life NA 22.51 hours 1compartment NA NA Human Human +DTXSID7029871 Css NA 0.8013 mg/L 3compartmentss NA 50% Human Human +DTXSID7029871 Css NA 5.178 mg/L 3compartmentss NA 95% Human Human +DTXSID7029871 Css NA 0.5494 mg/L PBTK NA 50% Human Human +DTXSID7029871 Css NA 3.456 mg/L PBTK NA 95% Human Human DTXSID7029871 Clint 77.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7029871 Fup 0.00953 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7029871 Vd NA 2.049 L/kg 1compartment NA NA Rat Human -DTXSID7029871 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7029871 TK.Half.Life NA 3.737 hours 1compartment NA NA Rat Human -DTXSID7029871 Css NA 0.3846 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029871 Css NA 2.144 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029871 Css NA 0.2485 mg/L PBTK NA 50% Rat Human -DTXSID7029871 Css NA 1.331 mg/L PBTK NA 95% Rat Human +DTXSID7029871 Vd NA 2.236 L/kg 1compartment NA NA Rat Human +DTXSID7029871 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7029871 TK.Half.Life NA 3.898 hours 1compartment NA NA Rat Human +DTXSID7029871 Css NA 0.1048 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029871 Css NA 0.6075 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029871 Css NA 0.07146 mg/L PBTK NA 50% Rat Human +DTXSID7029871 Css NA 0.4172 mg/L PBTK NA 95% Rat Human DTXSID7029879 Clint 55 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID7029879 Fup 0.062 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID7029879 Vd NA 2.928 L/kg 1compartment NA NA Human Human DTXSID7029879 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7029879 TK.Half.Life NA 12.6 hours 1compartment NA NA Human Human -DTXSID7029879 Css NA 0.5459 mg/L 3compartmentss NA 50% Human Human -DTXSID7029879 Css NA 3.481 mg/L 3compartmentss NA 95% Human Human -DTXSID7029879 Css NA 0.329 mg/L PBTK NA 50% Human Human -DTXSID7029879 Css NA 2.091 mg/L PBTK NA 95% Human Human +DTXSID7029879 Css NA 0.4283 mg/L 3compartmentss NA 50% Human Human +DTXSID7029879 Css NA 2.807 mg/L 3compartmentss NA 95% Human Human +DTXSID7029879 Css NA 0.3202 mg/L PBTK NA 50% Human Human +DTXSID7029879 Css NA 2.099 mg/L PBTK NA 95% Human Human DTXSID7029879 Clint 55 NA uL/min/million hepatocytes NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID7029879 Fup 0.062 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human DTXSID7029879 Vd NA 2.209 L/kg 1compartment NA NA Rat Human DTXSID7029879 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7029879 TK.Half.Life NA 2.56 hours 1compartment NA NA Rat Human -DTXSID7029879 Css NA 0.313 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029879 Css NA 1.663 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029879 Css NA 0.1763 mg/L PBTK NA 50% Rat Human -DTXSID7029879 Css NA 0.9296 mg/L PBTK NA 95% Rat Human -DTXSID7029904 Clint NA 0.08081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029904 Fup NA 0.018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7029904 Vd NA 3.108 L/kg 1compartment NA NA Human Human -DTXSID7029904 Days.Css NA 4824 Days PBTK NA NA Human Human -DTXSID7029904 TK.Half.Life NA 17430 hours 1compartment NA NA Human Human -DTXSID7029904 Css NA 675.8 mg/L 3compartmentss NA 50% Human Human -DTXSID7029904 Css NA 2415 mg/L 3compartmentss NA 95% Human Human -DTXSID7029904 Css NA 469.6 mg/L PBTK NA 50% Human Human -DTXSID7029904 Css NA 1590 mg/L PBTK NA 95% Human Human -DTXSID7029904 Clint NA 0.08081 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029904 Fup NA 0.018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7029904 Vd NA 2.329 L/kg 1compartment NA NA Rat Human -DTXSID7029904 Days.Css NA 2042 Days PBTK NA NA Rat Human -DTXSID7029904 TK.Half.Life NA 1835 hours 1compartment NA NA Rat Human -DTXSID7029904 Css NA 306.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID7029904 Css NA 762.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID7029904 Css NA 203.6 mg/L PBTK NA 50% Rat Human -DTXSID7029904 Css NA 466.9 mg/L PBTK NA 95% Rat Human +DTXSID7029879 Css NA 0.05312 mg/L 3compartmentss NA 50% Rat Human +DTXSID7029879 Css NA 0.2999 mg/L 3compartmentss NA 95% Rat Human +DTXSID7029879 Css NA 0.04114 mg/L PBTK NA 50% Rat Human +DTXSID7029879 Css NA 0.2323 mg/L PBTK NA 95% Rat Human DTXSID7030307 Clint 86.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7030307 Fup 0.0522 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7030307 Vd NA 1.32 L/kg 1compartment NA NA Human Human DTXSID7030307 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7030307 TK.Half.Life NA 2.354 hours 1compartment NA NA Human Human -DTXSID7030307 Css NA 0.1272 mg/L 3compartmentss NA 50% Human Human -DTXSID7030307 Css NA 0.8966 mg/L 3compartmentss NA 95% Human Human -DTXSID7030307 Css NA 0.08237 mg/L PBTK NA 50% Human Human -DTXSID7030307 Css NA 0.5531 mg/L PBTK NA 95% Human Human +DTXSID7030307 Css NA 0.1184 mg/L 3compartmentss NA 50% Human Human +DTXSID7030307 Css NA 0.9195 mg/L 3compartmentss NA 95% Human Human +DTXSID7030307 Css NA 0.07653 mg/L PBTK NA 50% Human Human +DTXSID7030307 Css NA 0.5659 mg/L PBTK NA 95% Human Human DTXSID7030307 Clint 86.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7030307 Fup 0.0522 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7030307 Vd NA 0.9967 L/kg 1compartment NA NA Rat Human DTXSID7030307 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7030307 TK.Half.Life NA 0.8969 hours 1compartment NA NA Rat Human -DTXSID7030307 Css NA 0.07082 mg/L 3compartmentss NA 50% Rat Human -DTXSID7030307 Css NA 0.4263 mg/L 3compartmentss NA 95% Rat Human -DTXSID7030307 Css NA 0.04293 mg/L PBTK NA 50% Rat Human -DTXSID7030307 Css NA 0.2495 mg/L PBTK NA 95% Rat Human -DTXSID7030432 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7030307 Css NA 0.01584 mg/L 3compartmentss NA 50% Rat Human +DTXSID7030307 Css NA 0.09793 mg/L 3compartmentss NA 95% Rat Human +DTXSID7030307 Css NA 0.009978 mg/L PBTK NA 50% Rat Human +DTXSID7030307 Css NA 0.06007 mg/L PBTK NA 95% Rat Human +DTXSID7030432 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7030432 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7030432 Vd NA 1.368 L/kg 1compartment NA NA Human Human DTXSID7030432 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7030432 TK.Half.Life NA 8.854 hours 1compartment NA NA Human Human -DTXSID7030432 Css NA 0.7454 mg/L 3compartmentss NA 50% Human Human -DTXSID7030432 Css NA 5.351 mg/L 3compartmentss NA 95% Human Human -DTXSID7030432 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID7030432 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID7030432 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7030432 Css NA 0.6466 mg/L 3compartmentss NA 50% Human Human +DTXSID7030432 Css NA 4.754 mg/L 3compartmentss NA 95% Human Human +DTXSID7030432 Css NA 0.6056 mg/L PBTK NA 50% Human Human +DTXSID7030432 Css NA 3.216 mg/L PBTK NA 95% Human Human +DTXSID7030432 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7030432 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7030432 Vd NA 1.416 L/kg 1compartment NA NA Rat Human DTXSID7030432 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7030432 TK.Half.Life NA 3.122 hours 1compartment NA NA Rat Human -DTXSID7030432 Css NA 0.1849 mg/L 3compartmentss NA 50% Rat Human -DTXSID7030432 Css NA 1.283 mg/L 3compartmentss NA 95% Rat Human -DTXSID7030432 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID7030432 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID7030432 Css NA 0.01594 mg/L 3compartmentss NA 50% Rat Human +DTXSID7030432 Css NA 0.1236 mg/L 3compartmentss NA 95% Rat Human +DTXSID7030432 Css NA 0.01478 mg/L PBTK NA 50% Rat Human +DTXSID7030432 Css NA 0.08478 mg/L PBTK NA 95% Rat Human DTXSID7030698 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7030698 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7030698 Vd NA 0.7584 L/kg 1compartment NA NA Human Human +DTXSID7030698 Vd NA 0.8009 L/kg 1compartment NA NA Human Human DTXSID7030698 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7030698 TK.Half.Life NA 4.909 hours 1compartment NA NA Human Human -DTXSID7030698 Css NA 0.8342 mg/L 3compartmentss NA 50% Human Human -DTXSID7030698 Css NA 5.559 mg/L 3compartmentss NA 95% Human Human -DTXSID7030698 Css NA 0.6989 mg/L PBTK NA 50% Human Human -DTXSID7030698 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID7030698 TK.Half.Life NA 5.184 hours 1compartment NA NA Human Human +DTXSID7030698 Css NA 0.697 mg/L 3compartmentss NA 50% Human Human +DTXSID7030698 Css NA 4.739 mg/L 3compartmentss NA 95% Human Human +DTXSID7030698 Css NA 0.5928 mg/L PBTK NA 50% Human Human +DTXSID7030698 Css NA 3.114 mg/L PBTK NA 95% Human Human DTXSID7030698 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7030698 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7030698 Vd NA 0.8 L/kg 1compartment NA NA Rat Human +DTXSID7030698 Vd NA 0.8366 L/kg 1compartment NA NA Rat Human DTXSID7030698 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7030698 TK.Half.Life NA 1.764 hours 1compartment NA NA Rat Human -DTXSID7030698 Css NA 0.2094 mg/L 3compartmentss NA 50% Rat Human -DTXSID7030698 Css NA 1.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID7030698 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID7030698 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID7031294 Clint NA 0.02053 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7031294 Fup NA 0.4998 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7031294 Vd NA 0.579 L/kg 1compartment NA NA Human Human +DTXSID7030698 TK.Half.Life NA 1.845 hours 1compartment NA NA Rat Human +DTXSID7030698 Css NA 0.01268 mg/L 3compartmentss NA 50% Rat Human +DTXSID7030698 Css NA 0.102 mg/L 3compartmentss NA 95% Rat Human +DTXSID7030698 Css NA 0.01048 mg/L PBTK NA 50% Rat Human +DTXSID7030698 Css NA 0.06705 mg/L PBTK NA 95% Rat Human +DTXSID7031248 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID7031248 Fup 0.967 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID7031248 Vd NA 0.7506 L/kg 1compartment NA NA Human Human +DTXSID7031248 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7031248 TK.Half.Life NA 5.023 hours 1compartment NA NA Human Human +DTXSID7031248 Css NA 0.7578 mg/L 3compartmentss NA 50% Human Human +DTXSID7031248 Css NA 2.181 mg/L 3compartmentss NA 95% Human Human +DTXSID7031248 Css NA 0.6408 mg/L PBTK NA 50% Human Human +DTXSID7031248 Css NA 1.627 mg/L PBTK NA 95% Human Human +DTXSID7031248 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID7031248 Fup 0.967 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID7031248 Vd NA 0.7899 L/kg 1compartment NA NA Rat Human +DTXSID7031248 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7031248 TK.Half.Life NA 1.801 hours 1compartment NA NA Rat Human +DTXSID7031248 Css NA 0.04572 mg/L 3compartmentss NA 50% Rat Human +DTXSID7031248 Css NA 0.1056 mg/L 3compartmentss NA 95% Rat Human +DTXSID7031248 Css NA 0.03932 mg/L PBTK NA 50% Rat Human +DTXSID7031248 Css NA 0.0756 mg/L PBTK NA 95% Rat Human +DTXSID7031290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7031290 Fup 0.0328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7031290 Vd NA 3.025 L/kg 1compartment NA NA Human Human +DTXSID7031290 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID7031290 TK.Half.Life NA 54.88 hours 1compartment NA NA Human Human +DTXSID7031290 Css NA 2.187 mg/L 3compartmentss NA 50% Human Human +DTXSID7031290 Css NA 14.55 mg/L 3compartmentss NA 95% Human Human +DTXSID7031290 Css NA 1.51 mg/L PBTK NA 50% Human Human +DTXSID7031290 Css NA 9.825 mg/L PBTK NA 95% Human Human +DTXSID7031290 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7031290 Fup 0.0328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7031290 Vd NA 2.267 L/kg 1compartment NA NA Rat Human +DTXSID7031290 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID7031290 TK.Half.Life NA 8.526 hours 1compartment NA NA Rat Human +DTXSID7031290 Css NA 0.2836 mg/L 3compartmentss NA 50% Rat Human +DTXSID7031290 Css NA 1.641 mg/L 3compartmentss NA 95% Rat Human +DTXSID7031290 Css NA 0.1933 mg/L PBTK NA 50% Rat Human +DTXSID7031290 Css NA 1.095 mg/L PBTK NA 95% Rat Human +DTXSID7031294 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7031294 Fup 0.843 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7031294 Vd NA 0.8017 L/kg 1compartment NA NA Human Human DTXSID7031294 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7031294 TK.Half.Life NA 7.232 hours 1compartment NA NA Human Human -DTXSID7031294 Css NA 1.382 mg/L 3compartmentss NA 50% Human Human -DTXSID7031294 Css NA 7.295 mg/L 3compartmentss NA 95% Human Human -DTXSID7031294 Css NA 1.063 mg/L PBTK NA 50% Human Human -DTXSID7031294 Css NA 4.608 mg/L PBTK NA 95% Human Human -DTXSID7031294 Clint NA 0.02053 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7031294 Fup NA 0.4998 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7031294 Vd NA 0.5971 L/kg 1compartment NA NA Rat Human +DTXSID7031294 TK.Half.Life NA 6.15 hours 1compartment NA NA Human Human +DTXSID7031294 Css NA 0.7947 mg/L 3compartmentss NA 50% Human Human +DTXSID7031294 Css NA 4.828 mg/L 3compartmentss NA 95% Human Human +DTXSID7031294 Css NA 0.6787 mg/L PBTK NA 50% Human Human +DTXSID7031294 Css NA 3.174 mg/L PBTK NA 95% Human Human +DTXSID7031294 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7031294 Fup 0.843 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7031294 Vd NA 0.8276 L/kg 1compartment NA NA Rat Human DTXSID7031294 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7031294 TK.Half.Life NA 2.588 hours 1compartment NA NA Rat Human -DTXSID7031294 Css NA 0.3844 mg/L 3compartmentss NA 50% Rat Human -DTXSID7031294 Css NA 1.826 mg/L 3compartmentss NA 95% Rat Human -DTXSID7031294 Css NA 0.2821 mg/L PBTK NA 50% Rat Human -DTXSID7031294 Css NA 1.08 mg/L PBTK NA 95% Rat Human -DTXSID7031458 Clint NA 2.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7031458 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7031458 Vd NA 1.767 L/kg 1compartment NA NA Human Human +DTXSID7031294 TK.Half.Life NA 2.165 hours 1compartment NA NA Rat Human +DTXSID7031294 Css NA 0.01489 mg/L 3compartmentss NA 50% Rat Human +DTXSID7031294 Css NA 0.1111 mg/L 3compartmentss NA 95% Rat Human +DTXSID7031294 Css NA 0.01212 mg/L PBTK NA 50% Rat Human +DTXSID7031294 Css NA 0.07501 mg/L PBTK NA 95% Rat Human +DTXSID7031458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7031458 Fup 0.334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7031458 Vd NA 1.159 L/kg 1compartment NA NA Human Human DTXSID7031458 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7031458 TK.Half.Life NA 11.54 hours 1compartment NA NA Human Human -DTXSID7031458 Css NA 0.6799 mg/L 3compartmentss NA 50% Human Human -DTXSID7031458 Css NA 3.194 mg/L 3compartmentss NA 95% Human Human -DTXSID7031458 Css NA 0.5222 mg/L PBTK NA 50% Human Human -DTXSID7031458 Css NA 2.199 mg/L PBTK NA 95% Human Human -DTXSID7031458 Clint NA 2.212 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7031458 Fup NA 0.3054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7031458 Vd NA 1.409 L/kg 1compartment NA NA Rat Human +DTXSID7031458 TK.Half.Life NA 1.436 hours 1compartment NA NA Human Human +DTXSID7031458 Css NA 0.06095 mg/L 3compartmentss NA 50% Human Human +DTXSID7031458 Css NA 0.4818 mg/L 3compartmentss NA 95% Human Human +DTXSID7031458 Css NA 0.04629 mg/L PBTK NA 50% Human Human +DTXSID7031458 Css NA 0.3281 mg/L PBTK NA 95% Human Human +DTXSID7031458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7031458 Fup 0.334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7031458 Vd NA 0.9864 L/kg 1compartment NA NA Rat Human DTXSID7031458 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7031458 TK.Half.Life NA 3.984 hours 1compartment NA NA Rat Human -DTXSID7031458 Css NA 0.3155 mg/L 3compartmentss NA 50% Rat Human -DTXSID7031458 Css NA 1.104 mg/L 3compartmentss NA 95% Rat Human -DTXSID7031458 Css NA 0.234 mg/L PBTK NA 50% Rat Human -DTXSID7031458 Css NA 0.7053 mg/L PBTK NA 95% Rat Human +DTXSID7031458 TK.Half.Life NA 0.6217 hours 1compartment NA NA Rat Human +DTXSID7031458 Css NA 0.007654 mg/L 3compartmentss NA 50% Rat Human +DTXSID7031458 Css NA 0.04454 mg/L 3compartmentss NA 95% Rat Human +DTXSID7031458 Css NA 0.005831 mg/L PBTK NA 50% Rat Human +DTXSID7031458 Css NA 0.03117 mg/L PBTK NA 95% Rat Human DTXSID7031531 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7031531 Fup 2e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7031531 Vd NA 1.156 L/kg 1compartment NA NA Human Human -DTXSID7031531 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID7031531 TK.Half.Life NA 74810 hours 1compartment NA NA Human Human -DTXSID7031531 Css NA 4960 mg/L 3compartmentss NA 50% Human Human -DTXSID7031531 Css NA 13730 mg/L 3compartmentss NA 95% Human Human -DTXSID7031531 Css NA 3087 mg/L PBTK NA 50% Human Human -DTXSID7031531 Css NA 8135 mg/L PBTK NA 95% Human Human +DTXSID7031531 Vd NA 0.4273 L/kg 1compartment NA NA Human Human +DTXSID7031531 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID7031531 TK.Half.Life NA 27660 hours 1compartment NA NA Human Human +DTXSID7031531 Css NA 3984 mg/L 3compartmentss NA 50% Human Human +DTXSID7031531 Css NA 13180 mg/L 3compartmentss NA 95% Human Human +DTXSID7031531 Css NA 2392 mg/L PBTK NA 50% Human Human +DTXSID7031531 Css NA 7528 mg/L PBTK NA 95% Human Human DTXSID7031531 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7031531 Fup 2e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7031531 Vd NA 0.8422 L/kg 1compartment NA NA Rat Human -DTXSID7031531 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID7031531 TK.Half.Life NA 18570 hours 1compartment NA NA Rat Human -DTXSID7031531 Css NA 1846 mg/L 3compartmentss NA 50% Rat Human -DTXSID7031531 Css NA 2339 mg/L 3compartmentss NA 95% Rat Human -DTXSID7031531 Css NA 1059 mg/L PBTK NA 50% Rat Human -DTXSID7031531 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID7031797 Clint NA 19.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7031531 Vd NA 0.3218 L/kg 1compartment NA NA Rat Human +DTXSID7031531 Days.Css NA 1960 Days PBTK NA NA Rat Human +DTXSID7031531 TK.Half.Life NA 7095 hours 1compartment NA NA Rat Human +DTXSID7031531 Css NA 351.5 mg/L 3compartmentss NA 50% Rat Human +DTXSID7031531 Css NA 551.8 mg/L 3compartmentss NA 95% Rat Human +DTXSID7031531 Css NA 198.9 mg/L PBTK NA 50% Rat Human +DTXSID7031531 Css NA 311.1 mg/L PBTK NA 95% Rat Human +DTXSID7031797 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7031797 Fup 0.32 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7031797 Vd NA 1.213 L/kg 1compartment NA NA Human Human DTXSID7031797 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7031797 TK.Half.Life NA 1.628 hours 1compartment NA NA Human Human -DTXSID7031797 Css NA 0.07754 mg/L 3compartmentss NA 50% Human Human -DTXSID7031797 Css NA 0.5454 mg/L 3compartmentss NA 95% Human Human -DTXSID7031797 Css NA 0.05879 mg/L PBTK NA 50% Human Human -DTXSID7031797 Css NA 0.3719 mg/L PBTK NA 95% Human Human -DTXSID7031797 Clint NA 19.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7031797 TK.Half.Life NA 3.096 hours 1compartment NA NA Human Human +DTXSID7031797 Css NA 0.214 mg/L 3compartmentss NA 50% Human Human +DTXSID7031797 Css NA 1.354 mg/L 3compartmentss NA 95% Human Human +DTXSID7031797 Css NA 0.1615 mg/L PBTK NA 50% Human Human +DTXSID7031797 Css NA 0.9284 mg/L PBTK NA 95% Human Human +DTXSID7031797 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7031797 Fup 0.32 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7031797 Vd NA 1.016 L/kg 1compartment NA NA Rat Human DTXSID7031797 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7031797 TK.Half.Life NA 0.6952 hours 1compartment NA NA Rat Human -DTXSID7031797 Css NA 0.04164 mg/L 3compartmentss NA 50% Rat Human -DTXSID7031797 Css NA 0.226 mg/L 3compartmentss NA 95% Rat Human -DTXSID7031797 Css NA 0.03029 mg/L PBTK NA 50% Rat Human -DTXSID7031797 Css NA 0.1507 mg/L PBTK NA 95% Rat Human -DTXSID7031903 Clint NA 0.00299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7031903 Fup NA 0.4019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7031903 Vd NA 0.387 L/kg 1compartment NA NA Human Human +DTXSID7031797 TK.Half.Life NA 1.374 hours 1compartment NA NA Rat Human +DTXSID7031797 Css NA 0.0253 mg/L 3compartmentss NA 50% Rat Human +DTXSID7031797 Css NA 0.1192 mg/L 3compartmentss NA 95% Rat Human +DTXSID7031797 Css NA 0.01908 mg/L PBTK NA 50% Rat Human +DTXSID7031797 Css NA 0.07838 mg/L PBTK NA 95% Rat Human +DTXSID7031903 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7031903 Fup 0.537 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7031903 Vd NA 0.6178 L/kg 1compartment NA NA Human Human DTXSID7031903 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7031903 TK.Half.Life NA 6.2 hours 1compartment NA NA Human Human -DTXSID7031903 Css NA 1.909 mg/L 3compartmentss NA 50% Human Human -DTXSID7031903 Css NA 8.387 mg/L 3compartmentss NA 95% Human Human -DTXSID7031903 Css NA 1.324 mg/L PBTK NA 50% Human Human -DTXSID7031903 Css NA 5.161 mg/L PBTK NA 95% Human Human -DTXSID7031903 Clint NA 0.00299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7031903 Fup NA 0.4019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7031903 Vd NA 0.3927 L/kg 1compartment NA NA Rat Human +DTXSID7031903 TK.Half.Life NA 0.5869 hours 1compartment NA NA Human Human +DTXSID7031903 Css NA 0.03533 mg/L 3compartmentss NA 50% Human Human +DTXSID7031903 Css NA 0.3496 mg/L 3compartmentss NA 95% Human Human +DTXSID7031903 Css NA 0.02758 mg/L PBTK NA 50% Human Human +DTXSID7031903 Css NA 0.2386 mg/L PBTK NA 95% Human Human +DTXSID7031903 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7031903 Fup 0.537 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7031903 Vd NA 0.6299 L/kg 1compartment NA NA Rat Human DTXSID7031903 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7031903 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human -DTXSID7031903 Css NA 0.527 mg/L 3compartmentss NA 50% Rat Human -DTXSID7031903 Css NA 1.945 mg/L 3compartmentss NA 95% Rat Human -DTXSID7031903 Css NA 0.348 mg/L PBTK NA 50% Rat Human -DTXSID7031903 Css NA 1.123 mg/L PBTK NA 95% Rat Human +DTXSID7031903 TK.Half.Life NA 0.2997 hours 1compartment NA NA Rat Human +DTXSID7031903 Css NA 0.004304 mg/L 3compartmentss NA 50% Rat Human +DTXSID7031903 Css NA 0.03502 mg/L 3compartmentss NA 95% Rat Human +DTXSID7031903 Css NA 0.003386 mg/L PBTK NA 50% Rat Human +DTXSID7031903 Css NA 0.02305 mg/L PBTK NA 95% Rat Human +DTXSID7031955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7031955 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7031955 Vd NA 2.244 L/kg 1compartment NA NA Human Human +DTXSID7031955 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7031955 TK.Half.Life NA 2.085 hours 1compartment NA NA Human Human +DTXSID7031955 Css NA 0.03692 mg/L 3compartmentss NA 50% Human Human +DTXSID7031955 Css NA 0.3678 mg/L 3compartmentss NA 95% Human Human +DTXSID7031955 Css NA 0.03295 mg/L PBTK NA 50% Human Human +DTXSID7031955 Css NA 0.2701 mg/L PBTK NA 95% Human Human +DTXSID7031955 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7031955 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7031955 Vd NA 1.849 L/kg 1compartment NA NA Rat Human +DTXSID7031955 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7031955 TK.Half.Life NA 0.7438 hours 1compartment NA NA Rat Human +DTXSID7031955 Css NA 0.004525 mg/L 3compartmentss NA 50% Rat Human +DTXSID7031955 Css NA 0.03546 mg/L 3compartmentss NA 95% Rat Human +DTXSID7031955 Css NA 0.004114 mg/L PBTK NA 50% Rat Human +DTXSID7031955 Css NA 0.02663 mg/L PBTK NA 95% Rat Human DTXSID7032004 Clint 30.38 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7032004 Fup 0.03758 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7032004 Vd NA 1.627 L/kg 1compartment NA NA Human Human DTXSID7032004 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7032004 TK.Half.Life NA 6.987 hours 1compartment NA NA Human Human -DTXSID7032004 Css NA 0.533 mg/L 3compartmentss NA 50% Human Human -DTXSID7032004 Css NA 4.906 mg/L 3compartmentss NA 95% Human Human -DTXSID7032004 Css NA 0.4026 mg/L PBTK NA 50% Human Human -DTXSID7032004 Css NA 3.273 mg/L PBTK NA 95% Human Human +DTXSID7032004 Css NA 0.4507 mg/L 3compartmentss NA 50% Human Human +DTXSID7032004 Css NA 3.663 mg/L 3compartmentss NA 95% Human Human +DTXSID7032004 Css NA 0.3938 mg/L PBTK NA 50% Human Human +DTXSID7032004 Css NA 3.202 mg/L PBTK NA 95% Human Human DTXSID7032004 Clint 30.38 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7032004 Fup 0.03758 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7032004 Vd NA 1.215 L/kg 1compartment NA NA Rat Human DTXSID7032004 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7032004 TK.Half.Life NA 2.603 hours 1compartment NA NA Rat Human -DTXSID7032004 Css NA 0.3006 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032004 Css NA 2.098 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032004 Css NA 0.215 mg/L PBTK NA 50% Rat Human -DTXSID7032004 Css NA 1.359 mg/L PBTK NA 95% Rat Human +DTXSID7032004 Css NA 0.05478 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032004 Css NA 0.3647 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032004 Css NA 0.04958 mg/L PBTK NA 50% Rat Human +DTXSID7032004 Css NA 0.3302 mg/L PBTK NA 95% Rat Human DTXSID7032006 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID7032006 Fup 0 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human +DTXSID7032006 Fup 0.0133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7032006 Vd NA 6.969 L/kg 1compartment NA NA Human Human +DTXSID7032006 Days.Css NA 2850 Days PBTK NA NA Human Human +DTXSID7032006 TK.Half.Life NA 10460 hours 1compartment NA NA Human Human +DTXSID7032006 Css NA 135.4 mg/L 3compartmentss NA 50% Human Human +DTXSID7032006 Css NA 622.7 mg/L 3compartmentss NA 95% Human Human +DTXSID7032006 Css NA 132.8 mg/L PBTK NA 50% Human Human +DTXSID7032006 Css NA 460.8 mg/L PBTK NA 95% Human Human DTXSID7032006 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID7032006 Fup 0 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human +DTXSID7032006 Fup 0.0133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7032006 Vd NA 5.532 L/kg 1compartment NA NA Rat Human +DTXSID7032006 Days.Css NA 772 Days PBTK NA NA Rat Human +DTXSID7032006 TK.Half.Life NA 1373 hours 1compartment NA NA Rat Human +DTXSID7032006 Css NA 8.346 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032006 Css NA 33.23 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032006 Css NA 8.313 mg/L PBTK NA 50% Rat Human +DTXSID7032006 Css NA 23.68 mg/L PBTK NA 95% Rat Human DTXSID7032345 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7032345 Fup 0.00236 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7032345 Vd NA 0.1677 L/kg 1compartment NA NA Human Human -DTXSID7032345 Days.Css NA 117 Days PBTK NA NA Human Human -DTXSID7032345 TK.Half.Life NA 460 hours 1compartment NA NA Human Human -DTXSID7032345 Css NA 356.8 mg/L 3compartmentss NA 50% Human Human -DTXSID7032345 Css NA 1828 mg/L 3compartmentss NA 95% Human Human -DTXSID7032345 Css NA 207 mg/L PBTK NA 50% Human Human -DTXSID7032345 Css NA 1043 mg/L PBTK NA 95% Human Human +DTXSID7032345 Vd NA 0.1696 L/kg 1compartment NA NA Human Human +DTXSID7032345 Days.Css NA 119 Days PBTK NA NA Human Human +DTXSID7032345 TK.Half.Life NA 464.9 hours 1compartment NA NA Human Human +DTXSID7032345 Css NA 192.9 mg/L 3compartmentss NA 50% Human Human +DTXSID7032345 Css NA 1042 mg/L 3compartmentss NA 95% Human Human +DTXSID7032345 Css NA 111.8 mg/L PBTK NA 50% Human Human +DTXSID7032345 Css NA 601.5 mg/L PBTK NA 95% Human Human DTXSID7032345 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7032345 Fup 0.00236 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7032345 Vd NA 0.165 L/kg 1compartment NA NA Rat Human -DTXSID7032345 Days.Css NA 35 Days PBTK NA NA Rat Human -DTXSID7032345 TK.Half.Life NA 154.2 hours 1compartment NA NA Rat Human -DTXSID7032345 Css NA 102.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032345 Css NA 432.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032345 Css NA 55.56 mg/L PBTK NA 50% Rat Human -DTXSID7032345 Css NA 233.7 mg/L PBTK NA 95% Rat Human +DTXSID7032345 Vd NA 0.1666 L/kg 1compartment NA NA Rat Human +DTXSID7032345 Days.Css NA 36 Days PBTK NA NA Rat Human +DTXSID7032345 TK.Half.Life NA 155.7 hours 1compartment NA NA Rat Human +DTXSID7032345 Css NA 1.06 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032345 Css NA 5.657 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032345 Css NA 0.5758 mg/L PBTK NA 50% Rat Human +DTXSID7032345 Css NA 3.066 mg/L PBTK NA 95% Rat Human DTXSID7032393 Clint 23.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032393 Fup 0.00327 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032393 Vd NA 1.486 L/kg 1compartment NA NA Human Human DTXSID7032393 Days.Css NA 6 Days PBTK NA NA Human Human DTXSID7032393 TK.Half.Life NA 41.58 hours 1compartment NA NA Human Human -DTXSID7032393 Css NA 4.866 mg/L 3compartmentss NA 50% Human Human -DTXSID7032393 Css NA 36.46 mg/L 3compartmentss NA 95% Human Human -DTXSID7032393 Css NA 2.992 mg/L PBTK NA 50% Human Human -DTXSID7032393 Css NA 21.9 mg/L PBTK NA 95% Human Human +DTXSID7032393 Css NA 4.68 mg/L 3compartmentss NA 50% Human Human +DTXSID7032393 Css NA 37.04 mg/L 3compartmentss NA 95% Human Human +DTXSID7032393 Css NA 2.873 mg/L PBTK NA 50% Human Human +DTXSID7032393 Css NA 22.05 mg/L PBTK NA 95% Human Human DTXSID7032393 Clint 23.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7032393 Fup 0.00327 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7032393 Vd NA 1.09 L/kg 1compartment NA NA Rat Human DTXSID7032393 Days.Css NA 3 Days PBTK NA NA Rat Human DTXSID7032393 TK.Half.Life NA 16.11 hours 1compartment NA NA Rat Human -DTXSID7032393 Css NA 2.765 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032393 Css NA 17.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032393 Css NA 1.586 mg/L PBTK NA 50% Rat Human -DTXSID7032393 Css NA 9.574 mg/L PBTK NA 95% Rat Human +DTXSID7032393 Css NA 0.618 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032393 Css NA 4.024 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032393 Css NA 0.368 mg/L PBTK NA 50% Rat Human +DTXSID7032393 Css NA 2.339 mg/L PBTK NA 95% Rat Human DTXSID7032424 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032424 Fup 0.3548 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7032424 Vd NA 0.5253 L/kg 1compartment NA NA Human Human +DTXSID7032424 Vd NA 0.6566 L/kg 1compartment NA NA Human Human DTXSID7032424 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7032424 TK.Half.Life NA 9.579 hours 1compartment NA NA Human Human -DTXSID7032424 Css NA 2.067 mg/L 3compartmentss NA 50% Human Human -DTXSID7032424 Css NA 8.375 mg/L 3compartmentss NA 95% Human Human -DTXSID7032424 Css NA 1.512 mg/L PBTK NA 50% Human Human -DTXSID7032424 Css NA 5.38 mg/L PBTK NA 95% Human Human +DTXSID7032424 TK.Half.Life NA 12.14 hours 1compartment NA NA Human Human +DTXSID7032424 Css NA 1.368 mg/L 3compartmentss NA 50% Human Human +DTXSID7032424 Css NA 5.961 mg/L 3compartmentss NA 95% Human Human +DTXSID7032424 Css NA 1.012 mg/L PBTK NA 50% Human Human +DTXSID7032424 Css NA 3.809 mg/L PBTK NA 95% Human Human DTXSID7032424 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7032424 Fup 0.3548 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7032424 Vd NA 0.5336 L/kg 1compartment NA NA Rat Human +DTXSID7032424 Vd NA 0.6273 L/kg 1compartment NA NA Rat Human DTXSID7032424 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7032424 TK.Half.Life NA 3.316 hours 1compartment NA NA Rat Human -DTXSID7032424 Css NA 0.5608 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032424 Css NA 1.987 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032424 Css NA 0.3926 mg/L PBTK NA 50% Rat Human -DTXSID7032424 Css NA 1.179 mg/L PBTK NA 95% Rat Human +DTXSID7032424 TK.Half.Life NA 3.909 hours 1compartment NA NA Rat Human +DTXSID7032424 Css NA 0.00945 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032424 Css NA 0.05656 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032424 Css NA 0.00674 mg/L PBTK NA 50% Rat Human +DTXSID7032424 Css NA 0.03594 mg/L PBTK NA 95% Rat Human DTXSID7032470 Clint 16.24 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032470 Fup 0.009787 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032470 Vd NA 1.521 L/kg 1compartment NA NA Human Human DTXSID7032470 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID7032470 TK.Half.Life NA 30.29 hours 1compartment NA NA Human Human -DTXSID7032470 Css NA 3.417 mg/L 3compartmentss NA 50% Human Human -DTXSID7032470 Css NA 28.45 mg/L 3compartmentss NA 95% Human Human -DTXSID7032470 Css NA 2.108 mg/L PBTK NA 50% Human Human -DTXSID7032470 Css NA 17.01 mg/L PBTK NA 95% Human Human +DTXSID7032470 Css NA 3.291 mg/L 3compartmentss NA 50% Human Human +DTXSID7032470 Css NA 28.69 mg/L 3compartmentss NA 95% Human Human +DTXSID7032470 Css NA 2.04 mg/L PBTK NA 50% Human Human +DTXSID7032470 Css NA 17.21 mg/L PBTK NA 95% Human Human DTXSID7032470 Clint 16.24 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7032470 Fup 0.009787 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7032470 Vd NA 1.123 L/kg 1compartment NA NA Rat Human DTXSID7032470 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID7032470 TK.Half.Life NA 11.59 hours 1compartment NA NA Rat Human -DTXSID7032470 Css NA 1.902 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032470 Css NA 13.62 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032470 Css NA 1.109 mg/L PBTK NA 50% Rat Human -DTXSID7032470 Css NA 7.589 mg/L PBTK NA 95% Rat Human -DTXSID7032474 Clint NA 9.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7032474 Fup NA 0.0724 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7032474 Vd NA 2.68 L/kg 1compartment NA NA Human Human -DTXSID7032474 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7032474 TK.Half.Life NA 35.64 hours 1compartment NA NA Human Human -DTXSID7032474 Css NA 1.717 mg/L 3compartmentss NA 50% Human Human -DTXSID7032474 Css NA 10.47 mg/L 3compartmentss NA 95% Human Human -DTXSID7032474 Css NA 1.174 mg/L PBTK NA 50% Human Human -DTXSID7032474 Css NA 6.941 mg/L PBTK NA 95% Human Human -DTXSID7032474 Clint NA 9.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7032474 Fup NA 0.0724 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7032474 Vd NA 2.013 L/kg 1compartment NA NA Rat Human -DTXSID7032474 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7032474 TK.Half.Life NA 7.726 hours 1compartment NA NA Rat Human -DTXSID7032474 Css NA 0.9448 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032474 Css NA 4.185 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032474 Css NA 0.6163 mg/L PBTK NA 50% Rat Human -DTXSID7032474 Css NA 2.649 mg/L PBTK NA 95% Rat Human +DTXSID7032470 Css NA 0.4252 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032470 Css NA 3.026 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032470 Css NA 0.2556 mg/L PBTK NA 50% Rat Human +DTXSID7032470 Css NA 1.747 mg/L PBTK NA 95% Rat Human +DTXSID7032474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7032474 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7032474 Vd NA 2.555 L/kg 1compartment NA NA Human Human +DTXSID7032474 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7032474 TK.Half.Life NA 17.94 hours 1compartment NA NA Human Human +DTXSID7032474 Css NA 0.8716 mg/L 3compartmentss NA 50% Human Human +DTXSID7032474 Css NA 5.679 mg/L 3compartmentss NA 95% Human Human +DTXSID7032474 Css NA 0.5886 mg/L PBTK NA 50% Human Human +DTXSID7032474 Css NA 3.664 mg/L PBTK NA 95% Human Human +DTXSID7032474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7032474 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7032474 Vd NA 1.915 L/kg 1compartment NA NA Rat Human +DTXSID7032474 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7032474 TK.Half.Life NA 4.407 hours 1compartment NA NA Rat Human +DTXSID7032474 Css NA 0.1126 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032474 Css NA 0.6181 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032474 Css NA 0.07478 mg/L PBTK NA 50% Rat Human +DTXSID7032474 Css NA 0.3978 mg/L PBTK NA 95% Rat Human DTXSID7032551 Clint 24.76 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032551 Fup 0.004357 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032551 Vd NA 1.294 L/kg 1compartment NA NA Human Human DTXSID7032551 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID7032551 TK.Half.Life NA 29.76 hours 1compartment NA NA Human Human -DTXSID7032551 Css NA 3.931 mg/L 3compartmentss NA 50% Human Human -DTXSID7032551 Css NA 36.22 mg/L 3compartmentss NA 95% Human Human -DTXSID7032551 Css NA 2.426 mg/L PBTK NA 50% Human Human -DTXSID7032551 Css NA 21.7 mg/L PBTK NA 95% Human Human +DTXSID7032551 Css NA 3.828 mg/L 3compartmentss NA 50% Human Human +DTXSID7032551 Css NA 36.86 mg/L 3compartmentss NA 95% Human Human +DTXSID7032551 Css NA 2.349 mg/L PBTK NA 50% Human Human +DTXSID7032551 Css NA 21.89 mg/L PBTK NA 95% Human Human DTXSID7032551 Clint 233 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID7032551 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID7032551 Css NA 0.2162 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7032551 Css NA 1.692 mg/L 3compartmentss NA 95% Rat Rat +DTXSID7032551 Css NA 0.05086 mg/L 3compartmentss NA 50% Rat Rat +DTXSID7032551 Css NA 0.4117 mg/L 3compartmentss NA 95% Rat Rat DTXSID7032553 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7032553 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7032553 Vd NA 3.028 L/kg 1compartment NA NA Human Human +DTXSID7032553 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7032553 Vd NA 3.047 L/kg 1compartment NA NA Human Human DTXSID7032553 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID7032553 TK.Half.Life NA 42520 hours 1compartment NA NA Human Human -DTXSID7032553 Css NA 1680 mg/L 3compartmentss NA 50% Human Human -DTXSID7032553 Css NA 4695 mg/L 3compartmentss NA 95% Human Human -DTXSID7032553 Css NA 1161 mg/L PBTK NA 50% Human Human -DTXSID7032553 Css NA 3010 mg/L PBTK NA 95% Human Human +DTXSID7032553 TK.Half.Life NA 42390 hours 1compartment NA NA Human Human +DTXSID7032553 Css NA 1594 mg/L 3compartmentss NA 50% Human Human +DTXSID7032553 Css NA 4566 mg/L 3compartmentss NA 95% Human Human +DTXSID7032553 Css NA 1100 mg/L PBTK NA 50% Human Human +DTXSID7032553 Css NA 2956 mg/L PBTK NA 95% Human Human DTXSID7032553 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7032553 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7032553 Vd NA 2.267 L/kg 1compartment NA NA Rat Human -DTXSID7032553 Days.Css NA 2990 Days PBTK NA NA Rat Human -DTXSID7032553 TK.Half.Life NA 3024 hours 1compartment NA NA Rat Human -DTXSID7032553 Css NA 456.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032553 Css NA 1061 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032553 Css NA 299.9 mg/L PBTK NA 50% Rat Human -DTXSID7032553 Css NA 631.4 mg/L PBTK NA 95% Rat Human +DTXSID7032553 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7032553 Vd NA 2.281 L/kg 1compartment NA NA Rat Human +DTXSID7032553 Days.Css NA 3004 Days PBTK NA NA Rat Human +DTXSID7032553 TK.Half.Life NA 2940 hours 1compartment NA NA Rat Human +DTXSID7032553 Css NA 100.7 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032553 Css NA 225.9 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032553 Css NA 68.72 mg/L PBTK NA 50% Rat Human +DTXSID7032553 Css NA 140 mg/L PBTK NA 95% Rat Human DTXSID7032555 Clint 8.336 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032555 Fup 0.02807 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032555 Vd NA 0.6752 L/kg 1compartment NA NA Human Human DTXSID7032555 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID7032555 TK.Half.Life NA 10.45 hours 1compartment NA NA Human Human -DTXSID7032555 Css NA 2.767 mg/L 3compartmentss NA 50% Human Human -DTXSID7032555 Css NA 22.77 mg/L 3compartmentss NA 95% Human Human -DTXSID7032555 Css NA 1.673 mg/L PBTK NA 50% Human Human -DTXSID7032555 Css NA 13.39 mg/L PBTK NA 95% Human Human +DTXSID7032555 Css NA 2.658 mg/L 3compartmentss NA 50% Human Human +DTXSID7032555 Css NA 21.97 mg/L 3compartmentss NA 95% Human Human +DTXSID7032555 Css NA 1.606 mg/L PBTK NA 50% Human Human +DTXSID7032555 Css NA 12.8 mg/L PBTK NA 95% Human Human DTXSID7032555 Clint 8.336 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7032555 Fup 0.02807 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7032555 Vd NA 0.5194 L/kg 1compartment NA NA Rat Human DTXSID7032555 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7032555 TK.Half.Life NA 4.933 hours 1compartment NA NA Rat Human -DTXSID7032555 Css NA 1.466 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032555 Css NA 9.567 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032555 Css NA 0.8285 mg/L PBTK NA 50% Rat Human -DTXSID7032555 Css NA 5.247 mg/L PBTK NA 95% Rat Human -DTXSID7032559 Clint NA 91.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7032559 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7032559 Vd NA 11.11 L/kg 1compartment NA NA Human Human -DTXSID7032559 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID7032559 TK.Half.Life NA 84.15 hours 1compartment NA NA Human Human -DTXSID7032559 Css NA 0.4648 mg/L 3compartmentss NA 50% Human Human -DTXSID7032559 Css NA 2.766 mg/L 3compartmentss NA 95% Human Human -DTXSID7032559 Css NA 0.5972 mg/L PBTK NA 50% Human Human -DTXSID7032559 Css NA 3.38 mg/L PBTK NA 95% Human Human -DTXSID7032559 Clint NA 91.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7032559 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7032559 Vd NA 8.79 L/kg 1compartment NA NA Rat Human -DTXSID7032559 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID7032559 TK.Half.Life NA 13.11 hours 1compartment NA NA Rat Human -DTXSID7032559 Css NA 0.2526 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032559 Css NA 1.057 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032559 Css NA 0.324 mg/L PBTK NA 50% Rat Human -DTXSID7032559 Css NA 1.378 mg/L PBTK NA 95% Rat Human +DTXSID7032555 Css NA 0.3353 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032555 Css NA 2.305 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032555 Css NA 0.1959 mg/L PBTK NA 50% Rat Human +DTXSID7032555 Css NA 1.312 mg/L PBTK NA 95% Rat Human +DTXSID7032559 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7032559 Fup 0.00837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7032559 Vd NA 11.22 L/kg 1compartment NA NA Human Human +DTXSID7032559 Days.Css NA 71 Days PBTK NA NA Human Human +DTXSID7032559 TK.Half.Life NA 337.1 hours 1compartment NA NA Human Human +DTXSID7032559 Css NA 1.862 mg/L 3compartmentss NA 50% Human Human +DTXSID7032559 Css NA 11.5 mg/L 3compartmentss NA 95% Human Human +DTXSID7032559 Css NA 2.4 mg/L PBTK NA 50% Human Human +DTXSID7032559 Css NA 14.4 mg/L PBTK NA 95% Human Human +DTXSID7032559 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7032559 Fup 0.00837 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7032559 Vd NA 8.875 L/kg 1compartment NA NA Rat Human +DTXSID7032559 Days.Css NA 43 Days PBTK NA NA Rat Human +DTXSID7032559 TK.Half.Life NA 47.87 hours 1compartment NA NA Rat Human +DTXSID7032559 Css NA 0.2317 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032559 Css NA 1.119 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032559 Css NA 0.3115 mg/L PBTK NA 50% Rat Human +DTXSID7032559 Css NA 1.605 mg/L PBTK NA 95% Rat Human DTXSID7032630 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7032630 Fup 0.138 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7032630 Vd NA 0.6359 L/kg 1compartment NA NA Human Human -DTXSID7032630 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7032630 TK.Half.Life NA 30.71 hours 1compartment NA NA Human Human -DTXSID7032630 Css NA 5.77 mg/L 3compartmentss NA 50% Human Human -DTXSID7032630 Css NA 17.84 mg/L 3compartmentss NA 95% Human Human -DTXSID7032630 Css NA 3.811 mg/L PBTK NA 50% Human Human -DTXSID7032630 Css NA 11.15 mg/L PBTK NA 95% Human Human +DTXSID7032630 Vd NA 1.15 L/kg 1compartment NA NA Human Human +DTXSID7032630 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID7032630 TK.Half.Life NA 63.83 hours 1compartment NA NA Human Human +DTXSID7032630 Css NA 6.198 mg/L 3compartmentss NA 50% Human Human +DTXSID7032630 Css NA 18.69 mg/L 3compartmentss NA 95% Human Human +DTXSID7032630 Css NA 4.244 mg/L PBTK NA 50% Human Human +DTXSID7032630 Css NA 11.85 mg/L PBTK NA 95% Human Human DTXSID7032630 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7032630 Fup 0.138 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7032630 Vd NA 0.5586 L/kg 1compartment NA NA Rat Human -DTXSID7032630 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7032630 TK.Half.Life NA 8.99 hours 1compartment NA NA Rat Human -DTXSID7032630 Css NA 1.607 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032630 Css NA 3.922 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032630 Css NA 1.003 mg/L PBTK NA 50% Rat Human -DTXSID7032630 Css NA 2.264 mg/L PBTK NA 95% Rat Human +DTXSID7032630 Vd NA 0.9104 L/kg 1compartment NA NA Rat Human +DTXSID7032630 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7032630 TK.Half.Life NA 15.18 hours 1compartment NA NA Rat Human +DTXSID7032630 Css NA 0.401 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032630 Css NA 0.9703 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032630 Css NA 0.2698 mg/L PBTK NA 50% Rat Human +DTXSID7032630 Css NA 0.5928 mg/L PBTK NA 95% Rat Human DTXSID7032638 Clint 53.93 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032638 Fup 0.001584 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7032638 Vd NA 0.772 L/kg 1compartment NA NA Human Human DTXSID7032638 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID7032638 TK.Half.Life NA 19.26 hours 1compartment NA NA Human Human -DTXSID7032638 Css NA 4.59 mg/L 3compartmentss NA 50% Human Human -DTXSID7032638 Css NA 43.52 mg/L 3compartmentss NA 95% Human Human -DTXSID7032638 Css NA 2.724 mg/L PBTK NA 50% Human Human -DTXSID7032638 Css NA 25.79 mg/L PBTK NA 95% Human Human +DTXSID7032638 Css NA 4.45 mg/L 3compartmentss NA 50% Human Human +DTXSID7032638 Css NA 44.12 mg/L 3compartmentss NA 95% Human Human +DTXSID7032638 Css NA 2.634 mg/L PBTK NA 50% Human Human +DTXSID7032638 Css NA 25.97 mg/L PBTK NA 95% Human Human DTXSID7032638 Clint 53.93 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7032638 Fup 0.001584 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7032638 Vd NA 0.5651 L/kg 1compartment NA NA Rat Human DTXSID7032638 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID7032638 TK.Half.Life NA 8.975 hours 1compartment NA NA Rat Human -DTXSID7032638 Css NA 2.623 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032638 Css NA 19.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032638 Css NA 1.449 mg/L PBTK NA 50% Rat Human -DTXSID7032638 Css NA 10.75 mg/L PBTK NA 95% Rat Human -DTXSID7032688 Clint NA 143.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7032688 Fup NA 0.008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7032688 Vd NA 3.15 L/kg 1compartment NA NA Human Human -DTXSID7032688 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7032688 TK.Half.Life NA 16.68 hours 1compartment NA NA Human Human -DTXSID7032688 Css NA 0.5326 mg/L 3compartmentss NA 50% Human Human -DTXSID7032688 Css NA 3.025 mg/L 3compartmentss NA 95% Human Human -DTXSID7032688 Css NA 0.3708 mg/L PBTK NA 50% Human Human -DTXSID7032688 Css NA 2.072 mg/L PBTK NA 95% Human Human -DTXSID7032688 Clint NA 143.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7032688 Fup NA 0.008 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7032688 Vd NA 2.361 L/kg 1compartment NA NA Rat Human -DTXSID7032688 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7032688 TK.Half.Life NA 2.71 hours 1compartment NA NA Rat Human -DTXSID7032688 Css NA 0.3032 mg/L 3compartmentss NA 50% Rat Human -DTXSID7032688 Css NA 1.318 mg/L 3compartmentss NA 95% Rat Human -DTXSID7032688 Css NA 0.2016 mg/L PBTK NA 50% Rat Human -DTXSID7032688 Css NA 0.8682 mg/L PBTK NA 95% Rat Human -DTXSID7033105 Clint NA 0.02899 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7033105 Fup NA 0.6339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7033105 Vd NA 0.5681 L/kg 1compartment NA NA Human Human +DTXSID7032638 Css NA 0.588 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032638 Css NA 4.674 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032638 Css NA 0.3361 mg/L PBTK NA 50% Rat Human +DTXSID7032638 Css NA 2.644 mg/L PBTK NA 95% Rat Human +DTXSID7032688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7032688 Fup 0.006 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7032688 Vd NA 3.138 L/kg 1compartment NA NA Human Human +DTXSID7032688 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID7032688 TK.Half.Life NA 96.11 hours 1compartment NA NA Human Human +DTXSID7032688 Css NA 3.456 mg/L 3compartmentss NA 50% Human Human +DTXSID7032688 Css NA 20.55 mg/L 3compartmentss NA 95% Human Human +DTXSID7032688 Css NA 2.418 mg/L PBTK NA 50% Human Human +DTXSID7032688 Css NA 14.28 mg/L PBTK NA 95% Human Human +DTXSID7032688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7032688 Fup 0.006 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7032688 Vd NA 2.351 L/kg 1compartment NA NA Rat Human +DTXSID7032688 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID7032688 TK.Half.Life NA 13.39 hours 1compartment NA NA Rat Human +DTXSID7032688 Css NA 0.459 mg/L 3compartmentss NA 50% Rat Human +DTXSID7032688 Css NA 2.155 mg/L 3compartmentss NA 95% Rat Human +DTXSID7032688 Css NA 0.3156 mg/L PBTK NA 50% Rat Human +DTXSID7032688 Css NA 1.494 mg/L PBTK NA 95% Rat Human +DTXSID7033105 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7033105 Fup 0.732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7033105 Vd NA 0.6166 L/kg 1compartment NA NA Human Human DTXSID7033105 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7033105 TK.Half.Life NA 5.541 hours 1compartment NA NA Human Human -DTXSID7033105 Css NA 1.155 mg/L 3compartmentss NA 50% Human Human -DTXSID7033105 Css NA 7.818 mg/L 3compartmentss NA 95% Human Human -DTXSID7033105 Css NA 0.8874 mg/L PBTK NA 50% Human Human -DTXSID7033105 Css NA 4.796 mg/L PBTK NA 95% Human Human -DTXSID7033105 Clint NA 0.02899 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7033105 Fup NA 0.6339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7033105 Vd NA 0.5832 L/kg 1compartment NA NA Rat Human +DTXSID7033105 TK.Half.Life NA 5.458 hours 1compartment NA NA Human Human +DTXSID7033105 Css NA 0.5978 mg/L 3compartmentss NA 50% Human Human +DTXSID7033105 Css NA 3.901 mg/L 3compartmentss NA 95% Human Human +DTXSID7033105 Css NA 0.4704 mg/L PBTK NA 50% Human Human +DTXSID7033105 Css NA 2.474 mg/L PBTK NA 95% Human Human +DTXSID7033105 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7033105 Fup 0.732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7033105 Vd NA 0.6332 L/kg 1compartment NA NA Rat Human DTXSID7033105 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7033105 TK.Half.Life NA 1.983 hours 1compartment NA NA Rat Human -DTXSID7033105 Css NA 0.3163 mg/L 3compartmentss NA 50% Rat Human -DTXSID7033105 Css NA 2.026 mg/L 3compartmentss NA 95% Rat Human -DTXSID7033105 Css NA 0.2316 mg/L PBTK NA 50% Rat Human -DTXSID7033105 Css NA 1.171 mg/L PBTK NA 95% Rat Human -DTXSID7034042 Clint NA 2683 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034042 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034042 Vd NA 1.243 L/kg 1compartment NA NA Human Human -DTXSID7034042 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7034042 TK.Half.Life NA 1.064 hours 1compartment NA NA Human Human -DTXSID7034042 Css NA 0.001976 mg/L 3compartmentss NA 50% Human Human -DTXSID7034042 Css NA 0.02205 mg/L 3compartmentss NA 95% Human Human -DTXSID7034042 Css NA 0.00132 mg/L PBTK NA 50% Human Human -DTXSID7034042 Css NA 0.01351 mg/L PBTK NA 95% Human Human -DTXSID7034042 Clint NA 2683 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034042 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034042 Vd NA 1.109 L/kg 1compartment NA NA Rat Human -DTXSID7034042 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7034042 TK.Half.Life NA 0.4193 hours 1compartment NA NA Rat Human -DTXSID7034042 Css NA 0.001144 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034042 Css NA 0.01144 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034042 Css NA 0.0007122 mg/L PBTK NA 50% Rat Human -DTXSID7034042 Css NA 0.00654 mg/L PBTK NA 95% Rat Human -DTXSID7034250 Clint NA 496.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034250 Fup NA 0.0131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034250 Vd NA 1.708 L/kg 1compartment NA NA Human Human -DTXSID7034250 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7034250 TK.Half.Life NA 2.431 hours 1compartment NA NA Human Human -DTXSID7034250 Css NA 0.09065 mg/L 3compartmentss NA 50% Human Human -DTXSID7034250 Css NA 0.8317 mg/L 3compartmentss NA 95% Human Human -DTXSID7034250 Css NA 0.05692 mg/L PBTK NA 50% Human Human -DTXSID7034250 Css NA 0.5054 mg/L PBTK NA 95% Human Human -DTXSID7034250 Clint NA 496.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034250 Fup NA 0.0131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034250 Vd NA 1.264 L/kg 1compartment NA NA Rat Human -DTXSID7034250 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7034250 TK.Half.Life NA 0.8273 hours 1compartment NA NA Rat Human -DTXSID7034250 Css NA 0.05211 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034250 Css NA 0.3958 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034250 Css NA 0.03065 mg/L PBTK NA 50% Rat Human -DTXSID7034250 Css NA 0.2246 mg/L PBTK NA 95% Rat Human +DTXSID7033105 TK.Half.Life NA 1.908 hours 1compartment NA NA Rat Human +DTXSID7033105 Css NA 0.003122 mg/L 3compartmentss NA 50% Rat Human +DTXSID7033105 Css NA 0.02188 mg/L 3compartmentss NA 95% Rat Human +DTXSID7033105 Css NA 0.002366 mg/L PBTK NA 50% Rat Human +DTXSID7033105 Css NA 0.01334 mg/L PBTK NA 95% Rat Human +DTXSID70333438 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70333438 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70333438 Vd NA 0.8789 L/kg 1compartment NA NA Human Human +DTXSID70333438 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70333438 TK.Half.Life NA 1.675 hours 1compartment NA NA Human Human +DTXSID70333438 Css NA 0.1522 mg/L 3compartmentss NA 50% Human Human +DTXSID70333438 Css NA 1.143 mg/L 3compartmentss NA 95% Human Human +DTXSID70333438 Css NA 0.1014 mg/L PBTK NA 50% Human Human +DTXSID70333438 Css NA 0.7119 mg/L PBTK NA 95% Human Human +DTXSID70333438 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70333438 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70333438 Vd NA 0.7179 L/kg 1compartment NA NA Rat Human +DTXSID70333438 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70333438 TK.Half.Life NA 0.7471 hours 1compartment NA NA Rat Human +DTXSID70333438 Css NA 0.01939 mg/L 3compartmentss NA 50% Rat Human +DTXSID70333438 Css NA 0.1164 mg/L 3compartmentss NA 95% Rat Human +DTXSID70333438 Css NA 0.01273 mg/L PBTK NA 50% Rat Human +DTXSID70333438 Css NA 0.07213 mg/L PBTK NA 95% Rat Human +DTXSID70340061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70340061 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70340061 Vd NA 1.388 L/kg 1compartment NA NA Human Human +DTXSID70340061 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID70340061 TK.Half.Life NA 13.11 hours 1compartment NA NA Human Human +DTXSID70340061 Css NA 1.497 mg/L 3compartmentss NA 50% Human Human +DTXSID70340061 Css NA 13.1 mg/L 3compartmentss NA 95% Human Human +DTXSID70340061 Css NA 0.9282 mg/L PBTK NA 50% Human Human +DTXSID70340061 Css NA 7.781 mg/L PBTK NA 95% Human Human +DTXSID70340061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70340061 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70340061 Vd NA 1.029 L/kg 1compartment NA NA Rat Human +DTXSID70340061 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70340061 TK.Half.Life NA 5.212 hours 1compartment NA NA Rat Human +DTXSID70340061 Css NA 0.1916 mg/L 3compartmentss NA 50% Rat Human +DTXSID70340061 Css NA 1.442 mg/L 3compartmentss NA 95% Rat Human +DTXSID70340061 Css NA 0.1158 mg/L PBTK NA 50% Rat Human +DTXSID70340061 Css NA 0.8334 mg/L PBTK NA 95% Rat Human +DTXSID7034250 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7034250 Fup 0.0218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7034250 Vd NA 2.044 L/kg 1compartment NA NA Human Human +DTXSID7034250 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7034250 TK.Half.Life NA 19.97 hours 1compartment NA NA Human Human +DTXSID7034250 Css NA 1.425 mg/L 3compartmentss NA 50% Human Human +DTXSID7034250 Css NA 11.86 mg/L 3compartmentss NA 95% Human Human +DTXSID7034250 Css NA 0.921 mg/L PBTK NA 50% Human Human +DTXSID7034250 Css NA 7.342 mg/L PBTK NA 95% Human Human +DTXSID7034250 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7034250 Fup 0.0218 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7034250 Vd NA 1.52 L/kg 1compartment NA NA Rat Human +DTXSID7034250 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7034250 TK.Half.Life NA 6.307 hours 1compartment NA NA Rat Human +DTXSID7034250 Css NA 0.1843 mg/L 3compartmentss NA 50% Rat Human +DTXSID7034250 Css NA 1.229 mg/L 3compartmentss NA 95% Rat Human +DTXSID7034250 Css NA 0.116 mg/L PBTK NA 50% Rat Human +DTXSID7034250 Css NA 0.7439 mg/L PBTK NA 95% Rat Human DTXSID7034252 Clint 3.349 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7034252 Fup 0.3834 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7034252 Vd NA 2.519 L/kg 1compartment NA NA Human Human DTXSID7034252 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID7034252 TK.Half.Life NA 17.2 hours 1compartment NA NA Human Human -DTXSID7034252 Css NA 0.705 mg/L 3compartmentss NA 50% Human Human -DTXSID7034252 Css NA 3.453 mg/L 3compartmentss NA 95% Human Human -DTXSID7034252 Css NA 0.549 mg/L PBTK NA 50% Human Human -DTXSID7034252 Css NA 2.482 mg/L PBTK NA 95% Human Human +DTXSID7034252 Css NA 0.6822 mg/L 3compartmentss NA 50% Human Human +DTXSID7034252 Css NA 3.401 mg/L 3compartmentss NA 95% Human Human +DTXSID7034252 Css NA 0.5288 mg/L PBTK NA 50% Human Human +DTXSID7034252 Css NA 2.45 mg/L PBTK NA 95% Human Human DTXSID7034252 Clint 3.349 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7034252 Fup 0.3834 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7034252 Vd NA 1.936 L/kg 1compartment NA NA Rat Human DTXSID7034252 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7034252 TK.Half.Life NA 4.126 hours 1compartment NA NA Rat Human -DTXSID7034252 Css NA 0.3468 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034252 Css NA 1.16 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034252 Css NA 0.2603 mg/L PBTK NA 50% Rat Human -DTXSID7034252 Css NA 0.7828 mg/L PBTK NA 95% Rat Human +DTXSID7034252 Css NA 0.07756 mg/L 3compartmentss NA 50% Rat Human +DTXSID7034252 Css NA 0.2682 mg/L 3compartmentss NA 95% Rat Human +DTXSID7034252 Css NA 0.06039 mg/L PBTK NA 50% Rat Human +DTXSID7034252 Css NA 0.1876 mg/L PBTK NA 95% Rat Human DTXSID7034383 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7034383 Fup 0.0106 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7034383 Vd NA 0.1935 L/kg 1compartment NA NA Human Human -DTXSID7034383 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID7034383 TK.Half.Life NA 118.2 hours 1compartment NA NA Human Human -DTXSID7034383 Css NA 69.6 mg/L 3compartmentss NA 50% Human Human -DTXSID7034383 Css NA 286.2 mg/L 3compartmentss NA 95% Human Human -DTXSID7034383 Css NA 41 mg/L PBTK NA 50% Human Human -DTXSID7034383 Css NA 164.7 mg/L PBTK NA 95% Human Human +DTXSID7034383 Vd NA 0.1648 L/kg 1compartment NA NA Human Human +DTXSID7034383 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID7034383 TK.Half.Life NA 100.6 hours 1compartment NA NA Human Human +DTXSID7034383 Css NA 54.31 mg/L 3compartmentss NA 50% Human Human +DTXSID7034383 Css NA 228.9 mg/L 3compartmentss NA 95% Human Human +DTXSID7034383 Css NA 31.37 mg/L PBTK NA 50% Human Human +DTXSID7034383 Css NA 130.4 mg/L PBTK NA 95% Human Human DTXSID7034383 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7034383 Fup 0.0106 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7034383 Vd NA 0.1861 L/kg 1compartment NA NA Rat Human -DTXSID7034383 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID7034383 TK.Half.Life NA 38.72 hours 1compartment NA NA Rat Human -DTXSID7034383 Css NA 19.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034383 Css NA 68.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034383 Css NA 10.86 mg/L PBTK NA 50% Rat Human -DTXSID7034383 Css NA 37.09 mg/L PBTK NA 95% Rat Human -DTXSID7034460 Clint NA 0.2095 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034460 Fup NA 0.0279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034460 Vd NA 0.1716 L/kg 1compartment NA NA Human Human -DTXSID7034460 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7034460 TK.Half.Life NA 26.52 hours 1compartment NA NA Human Human -DTXSID7034460 Css NA 26.68 mg/L 3compartmentss NA 50% Human Human -DTXSID7034460 Css NA 163 mg/L 3compartmentss NA 95% Human Human -DTXSID7034460 Css NA 15.64 mg/L PBTK NA 50% Human Human -DTXSID7034460 Css NA 94.61 mg/L PBTK NA 95% Human Human -DTXSID7034460 Clint NA 0.2095 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034460 Fup NA 0.0279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034460 Vd NA 0.1717 L/kg 1compartment NA NA Rat Human -DTXSID7034460 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7034460 TK.Half.Life NA 10.92 hours 1compartment NA NA Rat Human -DTXSID7034460 Css NA 9.328 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034460 Css NA 51.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034460 Css NA 5.082 mg/L PBTK NA 50% Rat Human -DTXSID7034460 Css NA 27.78 mg/L PBTK NA 95% Rat Human +DTXSID7034383 Vd NA 0.1637 L/kg 1compartment NA NA Rat Human +DTXSID7034383 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID7034383 TK.Half.Life NA 34.06 hours 1compartment NA NA Rat Human +DTXSID7034383 Css NA 0.5801 mg/L 3compartmentss NA 50% Rat Human +DTXSID7034383 Css NA 4.243 mg/L 3compartmentss NA 95% Rat Human +DTXSID7034383 Css NA 0.3166 mg/L PBTK NA 50% Rat Human +DTXSID7034383 Css NA 2.343 mg/L PBTK NA 95% Rat Human +DTXSID70344382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70344382 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70344382 Vd NA 1.271 L/kg 1compartment NA NA Human Human +DTXSID70344382 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70344382 TK.Half.Life NA 2.922 hours 1compartment NA NA Human Human +DTXSID70344382 Css NA 0.2218 mg/L 3compartmentss NA 50% Human Human +DTXSID70344382 Css NA 1.713 mg/L 3compartmentss NA 95% Human Human +DTXSID70344382 Css NA 0.149 mg/L PBTK NA 50% Human Human +DTXSID70344382 Css NA 1.082 mg/L PBTK NA 95% Human Human +DTXSID70344382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70344382 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70344382 Vd NA 0.9936 L/kg 1compartment NA NA Rat Human +DTXSID70344382 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70344382 TK.Half.Life NA 1.201 hours 1compartment NA NA Rat Human +DTXSID70344382 Css NA 0.02832 mg/L 3compartmentss NA 50% Rat Human +DTXSID70344382 Css NA 0.1747 mg/L 3compartmentss NA 95% Rat Human +DTXSID70344382 Css NA 0.01859 mg/L PBTK NA 50% Rat Human +DTXSID70344382 Css NA 0.1067 mg/L PBTK NA 95% Rat Human +DTXSID7034460 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7034460 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7034460 Vd NA 0.351 L/kg 1compartment NA NA Human Human +DTXSID7034460 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7034460 TK.Half.Life NA 1.191 hours 1compartment NA NA Human Human +DTXSID7034460 Css NA 0.3444 mg/L 3compartmentss NA 50% Human Human +DTXSID7034460 Css NA 1.977 mg/L 3compartmentss NA 95% Human Human +DTXSID7034460 Css NA 0.2268 mg/L PBTK NA 50% Human Human +DTXSID7034460 Css NA 1.238 mg/L PBTK NA 95% Human Human +DTXSID7034460 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7034460 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7034460 Vd NA 0.348 L/kg 1compartment NA NA Rat Human +DTXSID7034460 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7034460 TK.Half.Life NA 0.6904 hours 1compartment NA NA Rat Human +DTXSID7034460 Css NA 0.04043 mg/L 3compartmentss NA 50% Rat Human +DTXSID7034460 Css NA 0.1744 mg/L 3compartmentss NA 95% Rat Human +DTXSID7034460 Css NA 0.0262 mg/L PBTK NA 50% Rat Human +DTXSID7034460 Css NA 0.1043 mg/L PBTK NA 95% Rat Human DTXSID7034545 Clint 20.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7034545 Fup 0.09428 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7034545 Vd NA 1.628 L/kg 1compartment NA NA Human Human DTXSID7034545 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7034545 TK.Half.Life NA 3.993 hours 1compartment NA NA Human Human -DTXSID7034545 Css NA 0.251 mg/L 3compartmentss NA 50% Human Human -DTXSID7034545 Css NA 2.256 mg/L 3compartmentss NA 95% Human Human -DTXSID7034545 Css NA 0.1855 mg/L PBTK NA 50% Human Human -DTXSID7034545 Css NA 1.471 mg/L PBTK NA 95% Human Human +DTXSID7034545 Css NA 0.2431 mg/L 3compartmentss NA 50% Human Human +DTXSID7034545 Css NA 2.166 mg/L 3compartmentss NA 95% Human Human +DTXSID7034545 Css NA 0.1794 mg/L PBTK NA 50% Human Human +DTXSID7034545 Css NA 1.418 mg/L PBTK NA 95% Human Human DTXSID7034545 Clint 20.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7034545 Fup 0.09428 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7034545 Vd NA 1.582 L/kg 1compartment NA NA Rat Human DTXSID7034545 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7034545 TK.Half.Life NA 2.304 hours 1compartment NA NA Rat Human -DTXSID7034545 Css NA 0.1412 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034545 Css NA 0.9324 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034545 Css NA 0.09926 mg/L PBTK NA 50% Rat Human -DTXSID7034545 Css NA 0.5785 mg/L PBTK NA 95% Rat Human -DTXSID7034549 Clint NA 10.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034549 Fup NA 0.8602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034549 Vd NA 0.4952 L/kg 1compartment NA NA Human Human +DTXSID7034545 Css NA 0.0313 mg/L 3compartmentss NA 50% Rat Human +DTXSID7034545 Css NA 0.2169 mg/L 3compartmentss NA 95% Rat Human +DTXSID7034545 Css NA 0.02285 mg/L PBTK NA 50% Rat Human +DTXSID7034545 Css NA 0.1375 mg/L PBTK NA 95% Rat Human +DTXSID7034549 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7034549 Fup 0.824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7034549 Vd NA 0.4838 L/kg 1compartment NA NA Human Human DTXSID7034549 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7034549 TK.Half.Life NA 0.4994 hours 1compartment NA NA Human Human -DTXSID7034549 Css NA 0.06313 mg/L 3compartmentss NA 50% Human Human -DTXSID7034549 Css NA 0.5292 mg/L 3compartmentss NA 95% Human Human -DTXSID7034549 Css NA 0.04628 mg/L PBTK NA 50% Human Human -DTXSID7034549 Css NA 0.3422 mg/L PBTK NA 95% Human Human -DTXSID7034549 Clint NA 10.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034549 Fup NA 0.8602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034549 Vd NA 0.5165 L/kg 1compartment NA NA Rat Human +DTXSID7034549 TK.Half.Life NA 3.798 hours 1compartment NA NA Human Human +DTXSID7034549 Css NA 1.054 mg/L 3compartmentss NA 50% Human Human +DTXSID7034549 Css NA 5.786 mg/L 3compartmentss NA 95% Human Human +DTXSID7034549 Css NA 0.786 mg/L PBTK NA 50% Human Human +DTXSID7034549 Css NA 3.604 mg/L PBTK NA 95% Human Human +DTXSID7034549 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7034549 Fup 0.824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7034549 Vd NA 0.5045 L/kg 1compartment NA NA Rat Human DTXSID7034549 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7034549 TK.Half.Life NA 0.2608 hours 1compartment NA NA Rat Human -DTXSID7034549 Css NA 0.03122 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034549 Css NA 0.2183 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034549 Css NA 0.02228 mg/L PBTK NA 50% Rat Human -DTXSID7034549 Css NA 0.1338 mg/L PBTK NA 95% Rat Human -DTXSID7034624 Clint NA 10.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034624 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034624 Vd NA 0.9885 L/kg 1compartment NA NA Human Human -DTXSID7034624 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7034624 TK.Half.Life NA 28.8 hours 1compartment NA NA Human Human -DTXSID7034624 Css NA 5.222 mg/L 3compartmentss NA 50% Human Human -DTXSID7034624 Css NA 47.75 mg/L 3compartmentss NA 95% Human Human -DTXSID7034624 Css NA 3.137 mg/L PBTK NA 50% Human Human -DTXSID7034624 Css NA 27.74 mg/L PBTK NA 95% Human Human +DTXSID7034549 TK.Half.Life NA 1.35 hours 1compartment NA NA Rat Human +DTXSID7034549 Css NA 0.06299 mg/L 3compartmentss NA 50% Rat Human +DTXSID7034549 Css NA 0.3388 mg/L 3compartmentss NA 95% Rat Human +DTXSID7034549 Css NA 0.04649 mg/L PBTK NA 50% Rat Human +DTXSID7034549 Css NA 0.2031 mg/L PBTK NA 95% Rat Human +DTXSID7034624 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7034624 Fup 0.012 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7034624 Vd NA 65.4 L/kg 1compartment NA NA Human Human +DTXSID7034624 Days.Css NA 493 Days PBTK NA NA Human Human +DTXSID7034624 TK.Half.Life NA 1923 hours 1compartment NA NA Human Human +DTXSID7034624 Css NA 0.3236 mg/L 3compartmentss NA 50% Human Human +DTXSID7034624 Css NA 2.057 mg/L 3compartmentss NA 95% Human Human +DTXSID7034624 Css NA 2.394 mg/L PBTK NA 50% Human Human +DTXSID7034624 Css NA 14.35 mg/L PBTK NA 95% Human Human DTXSID7034624 Clint 23.7 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID7034624 Fup 0.0248 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID7034624 Vd NA 1.126 L/kg 1compartment NA NA Rat Rat -DTXSID7034624 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID7034624 TK.Half.Life NA 4.271 hours 1compartment NA NA Rat Rat -DTXSID7034624 Css NA 0.6292 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7034624 Css NA 4.349 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7034624 Css NA 0.371 mg/L PBTK NA 50% Rat Rat -DTXSID7034624 Css NA 2.442 mg/L PBTK NA 95% Rat Rat -DTXSID7034672 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034672 Fup NA 0.5269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034672 Vd NA 2.442 L/kg 1compartment NA NA Human Human -DTXSID7034672 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID7034672 TK.Half.Life NA 68.22 hours 1compartment NA NA Human Human -DTXSID7034672 Css NA 2.895 mg/L 3compartmentss NA 50% Human Human -DTXSID7034672 Css NA 11.68 mg/L 3compartmentss NA 95% Human Human -DTXSID7034672 Css NA 2.369 mg/L PBTK NA 50% Human Human -DTXSID7034672 Css NA 8.082 mg/L PBTK NA 95% Human Human -DTXSID7034672 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034672 Fup NA 0.5269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034672 Vd NA 1.925 L/kg 1compartment NA NA Rat Human -DTXSID7034672 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7034672 TK.Half.Life NA 10.5 hours 1compartment NA NA Rat Human -DTXSID7034672 Css NA 0.7707 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034672 Css NA 2.651 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034672 Css NA 0.6128 mg/L PBTK NA 50% Rat Human -DTXSID7034672 Css NA 1.679 mg/L PBTK NA 95% Rat Human +DTXSID7034624 Vd NA 55.95 L/kg 1compartment NA NA Rat Rat +DTXSID7034624 Days.Css NA 276 Days PBTK NA NA Rat Rat +DTXSID7034624 TK.Half.Life NA 257.4 hours 1compartment NA NA Rat Rat +DTXSID7034624 Css NA 0.03461 mg/L 3compartmentss NA 50% Rat Rat +DTXSID7034624 Css NA 0.1601 mg/L 3compartmentss NA 95% Rat Rat +DTXSID7034624 Css NA 0.2845 mg/L PBTK NA 50% Rat Rat +DTXSID7034624 Css NA 1.341 mg/L PBTK NA 95% Rat Rat DTXSID7034674 Clint 101 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7034674 Fup 0.0132 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7034674 Vd NA 2.284 L/kg 1compartment NA NA Human Human DTXSID7034674 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7034674 TK.Half.Life NA 8.608 hours 1compartment NA NA Human Human -DTXSID7034674 Css NA 0.3682 mg/L 3compartmentss NA 50% Human Human -DTXSID7034674 Css NA 2.491 mg/L 3compartmentss NA 95% Human Human -DTXSID7034674 Css NA 0.245 mg/L PBTK NA 50% Human Human -DTXSID7034674 Css NA 1.608 mg/L PBTK NA 95% Human Human +DTXSID7034674 Css NA 0.3614 mg/L 3compartmentss NA 50% Human Human +DTXSID7034674 Css NA 2.407 mg/L 3compartmentss NA 95% Human Human +DTXSID7034674 Css NA 0.2394 mg/L PBTK NA 50% Human Human +DTXSID7034674 Css NA 1.534 mg/L PBTK NA 95% Human Human DTXSID7034674 Clint 101 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7034674 Fup 0.0132 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7034674 Vd NA 1.698 L/kg 1compartment NA NA Rat Human DTXSID7034674 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7034674 TK.Half.Life NA 2.494 hours 1compartment NA NA Rat Human -DTXSID7034674 Css NA 0.2084 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034674 Css NA 1.162 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034674 Css NA 0.1308 mg/L PBTK NA 50% Rat Human -DTXSID7034674 Css NA 0.7269 mg/L PBTK NA 95% Rat Human +DTXSID7034674 Css NA 0.04685 mg/L 3compartmentss NA 50% Rat Human +DTXSID7034674 Css NA 0.2786 mg/L 3compartmentss NA 95% Rat Human +DTXSID7034674 Css NA 0.03048 mg/L PBTK NA 50% Rat Human +DTXSID7034674 Css NA 0.1802 mg/L PBTK NA 95% Rat Human DTXSID7034676 Clint 19.53 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7034676 Fup 0.06539 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7034676 Vd NA 2.656 L/kg 1compartment NA NA Human Human DTXSID7034676 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID7034676 TK.Half.Life NA 19.64 hours 1compartment NA NA Human Human -DTXSID7034676 Css NA 0.997 mg/L 3compartmentss NA 50% Human Human -DTXSID7034676 Css NA 6.183 mg/L 3compartmentss NA 95% Human Human -DTXSID7034676 Css NA 0.6286 mg/L PBTK NA 50% Human Human -DTXSID7034676 Css NA 3.77 mg/L PBTK NA 95% Human Human +DTXSID7034676 Css NA 0.7717 mg/L 3compartmentss NA 50% Human Human +DTXSID7034676 Css NA 4.811 mg/L 3compartmentss NA 95% Human Human +DTXSID7034676 Css NA 0.6105 mg/L PBTK NA 50% Human Human +DTXSID7034676 Css NA 3.806 mg/L PBTK NA 95% Human Human DTXSID7034676 Clint 81.88 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID7034676 Fup 0.1072 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID7034676 Vd NA 2.133 L/kg 1compartment NA NA Rat Rat DTXSID7034676 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID7034676 TK.Half.Life NA 1.437 hours 1compartment NA NA Rat Rat -DTXSID7034676 Css NA 0.1256 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7034676 Css NA 0.668 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7034676 Css NA 0.07248 mg/L PBTK NA 50% Rat Rat -DTXSID7034676 Css NA 0.3799 mg/L PBTK NA 95% Rat Rat +DTXSID7034676 Css NA 0.02058 mg/L 3compartmentss NA 50% Rat Rat +DTXSID7034676 Css NA 0.1117 mg/L 3compartmentss NA 95% Rat Rat +DTXSID7034676 Css NA 0.01687 mg/L PBTK NA 50% Rat Rat +DTXSID7034676 Css NA 0.09157 mg/L PBTK NA 95% Rat Rat +DTXSID70346760 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70346760 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70346760 Vd NA 2.789 L/kg 1compartment NA NA Human Human +DTXSID70346760 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID70346760 TK.Half.Life NA 55.59 hours 1compartment NA NA Human Human +DTXSID70346760 Css NA 2.674 mg/L 3compartmentss NA 50% Human Human +DTXSID70346760 Css NA 18.21 mg/L 3compartmentss NA 95% Human Human +DTXSID70346760 Css NA 1.804 mg/L PBTK NA 50% Human Human +DTXSID70346760 Css NA 11.72 mg/L PBTK NA 95% Human Human +DTXSID70346760 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70346760 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70346760 Vd NA 2.083 L/kg 1compartment NA NA Rat Human +DTXSID70346760 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID70346760 TK.Half.Life NA 10.91 hours 1compartment NA NA Rat Human +DTXSID70346760 Css NA 0.3467 mg/L 3compartmentss NA 50% Rat Human +DTXSID70346760 Css NA 2.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID70346760 Css NA 0.2298 mg/L PBTK NA 50% Rat Human +DTXSID70346760 Css NA 1.36 mg/L PBTK NA 95% Rat Human DTXSID7034753 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7034753 Fup 0.0649 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7034753 Vd NA 0.2239 L/kg 1compartment NA NA Human Human -DTXSID7034753 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7034753 TK.Half.Life NA 22.33 hours 1compartment NA NA Human Human -DTXSID7034753 Css NA 16.55 mg/L 3compartmentss NA 50% Human Human -DTXSID7034753 Css NA 68.17 mg/L 3compartmentss NA 95% Human Human -DTXSID7034753 Css NA 9.855 mg/L PBTK NA 50% Human Human -DTXSID7034753 Css NA 39.59 mg/L PBTK NA 95% Human Human +DTXSID7034753 Vd NA 0.1981 L/kg 1compartment NA NA Human Human +DTXSID7034753 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7034753 TK.Half.Life NA 19.75 hours 1compartment NA NA Human Human +DTXSID7034753 Css NA 14.1 mg/L 3compartmentss NA 50% Human Human +DTXSID7034753 Css NA 59.86 mg/L 3compartmentss NA 95% Human Human +DTXSID7034753 Css NA 8.386 mg/L PBTK NA 50% Human Human +DTXSID7034753 Css NA 34.34 mg/L PBTK NA 95% Human Human DTXSID7034753 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7034753 Fup 0.0649 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7034753 Vd NA 0.2199 L/kg 1compartment NA NA Rat Human +DTXSID7034753 Vd NA 0.1998 L/kg 1compartment NA NA Rat Human DTXSID7034753 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7034753 TK.Half.Life NA 7.472 hours 1compartment NA NA Rat Human -DTXSID7034753 Css NA 4.641 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034753 Css NA 15.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034753 Css NA 2.588 mg/L PBTK NA 50% Rat Human -DTXSID7034753 Css NA 8.681 mg/L PBTK NA 95% Rat Human -DTXSID7034836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034836 Fup NA 0.2762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7034836 Vd NA 0.3395 L/kg 1compartment NA NA Human Human -DTXSID7034836 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7034836 TK.Half.Life NA 7.953 hours 1compartment NA NA Human Human -DTXSID7034836 Css NA 2.886 mg/L 3compartmentss NA 50% Human Human -DTXSID7034836 Css NA 11.01 mg/L 3compartmentss NA 95% Human Human -DTXSID7034836 Css NA 1.912 mg/L PBTK NA 50% Human Human -DTXSID7034836 Css NA 6.684 mg/L PBTK NA 95% Human Human -DTXSID7034836 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034836 Fup NA 0.2762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7034836 Vd NA 0.3622 L/kg 1compartment NA NA Rat Human -DTXSID7034836 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7034836 TK.Half.Life NA 2.892 hours 1compartment NA NA Rat Human -DTXSID7034836 Css NA 0.7922 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034836 Css NA 2.571 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034836 Css NA 0.4987 mg/L PBTK NA 50% Rat Human -DTXSID7034836 Css NA 1.467 mg/L PBTK NA 95% Rat Human +DTXSID7034753 TK.Half.Life NA 6.789 hours 1compartment NA NA Rat Human +DTXSID7034753 Css NA 0.3368 mg/L 3compartmentss NA 50% Rat Human +DTXSID7034753 Css NA 1.995 mg/L 3compartmentss NA 95% Rat Human +DTXSID7034753 Css NA 0.1908 mg/L PBTK NA 50% Rat Human +DTXSID7034753 Css NA 1.12 mg/L PBTK NA 95% Rat Human DTXSID7034961 Clint 2.574 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID7034961 Fup 0.2857 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7034961 Vd NA 0.6325 L/kg 1compartment NA NA Human Human +DTXSID7034961 Vd NA 0.7657 L/kg 1compartment NA NA Human Human DTXSID7034961 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7034961 TK.Half.Life NA 3.059 hours 1compartment NA NA Human Human -DTXSID7034961 Css NA 0.5198 mg/L 3compartmentss NA 50% Human Human -DTXSID7034961 Css NA 2.66 mg/L 3compartmentss NA 95% Human Human -DTXSID7034961 Css NA 0.3708 mg/L PBTK NA 50% Human Human -DTXSID7034961 Css NA 1.715 mg/L PBTK NA 95% Human Human +DTXSID7034961 TK.Half.Life NA 3.735 hours 1compartment NA NA Human Human +DTXSID7034961 Css NA 0.505 mg/L 3compartmentss NA 50% Human Human +DTXSID7034961 Css NA 2.626 mg/L 3compartmentss NA 95% Human Human +DTXSID7034961 Css NA 0.3637 mg/L PBTK NA 50% Human Human +DTXSID7034961 Css NA 1.689 mg/L PBTK NA 95% Human Human DTXSID7034961 Clint 2.574 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID7034961 Fup 0.2857 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7034961 Vd NA 0.5922 L/kg 1compartment NA NA Rat Human +DTXSID7034961 Vd NA 0.6881 L/kg 1compartment NA NA Rat Human DTXSID7034961 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7034961 TK.Half.Life NA 1.573 hours 1compartment NA NA Rat Human -DTXSID7034961 Css NA 0.2426 mg/L 3compartmentss NA 50% Rat Human -DTXSID7034961 Css NA 0.925 mg/L 3compartmentss NA 95% Rat Human -DTXSID7034961 Css NA 0.1647 mg/L PBTK NA 50% Rat Human -DTXSID7034961 Css NA 0.5558 mg/L PBTK NA 95% Rat Human -DTXSID7035010 Clint NA 1.698 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7035010 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7035010 Vd NA 0.1799 L/kg 1compartment NA NA Human Human -DTXSID7035010 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID7035010 TK.Half.Life NA 35.88 hours 1compartment NA NA Human Human -DTXSID7035010 Css NA 35.97 mg/L 3compartmentss NA 50% Human Human -DTXSID7035010 Css NA 257.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7035010 Css NA 20.94 mg/L PBTK NA 50% Human Human -DTXSID7035010 Css NA 150.3 mg/L PBTK NA 95% Human Human -DTXSID7035010 Clint NA 1.698 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7035010 Fup NA 0.0085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7035010 Vd NA 0.1756 L/kg 1compartment NA NA Rat Human -DTXSID7035010 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7035010 TK.Half.Life NA 19.23 hours 1compartment NA NA Rat Human -DTXSID7035010 Css NA 16.48 mg/L 3compartmentss NA 50% Rat Human -DTXSID7035010 Css NA 100.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID7035010 Css NA 8.968 mg/L PBTK NA 50% Rat Human -DTXSID7035010 Css NA 54.53 mg/L PBTK NA 95% Rat Human -DTXSID7035305 Clint NA 23.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7035305 Fup NA 0.1723 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7035305 Vd NA 2.868 L/kg 1compartment NA NA Human Human +DTXSID7034961 TK.Half.Life NA 1.822 hours 1compartment NA NA Rat Human +DTXSID7034961 Css NA 0.0548 mg/L 3compartmentss NA 50% Rat Human +DTXSID7034961 Css NA 0.2179 mg/L 3compartmentss NA 95% Rat Human +DTXSID7034961 Css NA 0.03926 mg/L PBTK NA 50% Rat Human +DTXSID7034961 Css NA 0.1355 mg/L PBTK NA 95% Rat Human +DTXSID7035010 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7035010 Fup 0.0504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7035010 Vd NA 0.4468 L/kg 1compartment NA NA Human Human +DTXSID7035010 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7035010 TK.Half.Life NA 5.263 hours 1compartment NA NA Human Human +DTXSID7035010 Css NA 1.945 mg/L 3compartmentss NA 50% Human Human +DTXSID7035010 Css NA 13.99 mg/L 3compartmentss NA 95% Human Human +DTXSID7035010 Css NA 1.176 mg/L PBTK NA 50% Human Human +DTXSID7035010 Css NA 8.127 mg/L PBTK NA 95% Human Human +DTXSID7035010 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7035010 Fup 0.0504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7035010 Vd NA 0.368 L/kg 1compartment NA NA Rat Human +DTXSID7035010 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7035010 TK.Half.Life NA 2.67 hours 1compartment NA NA Rat Human +DTXSID7035010 Css NA 0.2396 mg/L 3compartmentss NA 50% Rat Human +DTXSID7035010 Css NA 1.32 mg/L 3compartmentss NA 95% Rat Human +DTXSID7035010 Css NA 0.1401 mg/L PBTK NA 50% Rat Human +DTXSID7035010 Css NA 0.7494 mg/L PBTK NA 95% Rat Human +DTXSID7035305 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7035305 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7035305 Vd NA 2.643 L/kg 1compartment NA NA Human Human DTXSID7035305 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7035305 TK.Half.Life NA 12.92 hours 1compartment NA NA Human Human -DTXSID7035305 Css NA 0.4617 mg/L 3compartmentss NA 50% Human Human -DTXSID7035305 Css NA 2.764 mg/L 3compartmentss NA 95% Human Human -DTXSID7035305 Css NA 0.3283 mg/L PBTK NA 50% Human Human -DTXSID7035305 Css NA 1.889 mg/L PBTK NA 95% Human Human -DTXSID7035305 Clint NA 23.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7035305 Fup NA 0.1723 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7035305 Vd NA 2.165 L/kg 1compartment NA NA Rat Human +DTXSID7035305 TK.Half.Life NA 13.11 hours 1compartment NA NA Human Human +DTXSID7035305 Css NA 0.5618 mg/L 3compartmentss NA 50% Human Human +DTXSID7035305 Css NA 3.598 mg/L 3compartmentss NA 95% Human Human +DTXSID7035305 Css NA 0.385 mg/L PBTK NA 50% Human Human +DTXSID7035305 Css NA 2.393 mg/L PBTK NA 95% Human Human +DTXSID7035305 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7035305 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7035305 Vd NA 1.99 L/kg 1compartment NA NA Rat Human DTXSID7035305 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7035305 TK.Half.Life NA 2.69 hours 1compartment NA NA Rat Human -DTXSID7035305 Css NA 0.2511 mg/L 3compartmentss NA 50% Rat Human -DTXSID7035305 Css NA 1.253 mg/L 3compartmentss NA 95% Rat Human -DTXSID7035305 Css NA 0.1713 mg/L PBTK NA 50% Rat Human -DTXSID7035305 Css NA 0.8247 mg/L PBTK NA 95% Rat Human -DTXSID7037131 Clint NA 19.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7035305 TK.Half.Life NA 3.132 hours 1compartment NA NA Rat Human +DTXSID7035305 Css NA 0.0705 mg/L 3compartmentss NA 50% Rat Human +DTXSID7035305 Css NA 0.3804 mg/L 3compartmentss NA 95% Rat Human +DTXSID7035305 Css NA 0.04832 mg/L PBTK NA 50% Rat Human +DTXSID7035305 Css NA 0.2526 mg/L PBTK NA 95% Rat Human +DTXSID7037131 Clint 13 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID7037131 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7037131 Vd NA 0.1742 L/kg 1compartment NA NA Human Human -DTXSID7037131 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7037131 TK.Half.Life NA 16.29 hours 1compartment NA NA Human Human -DTXSID7037131 Css NA 17.76 mg/L 3compartmentss NA 50% Human Human -DTXSID7037131 Css NA 166.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7037131 Css NA 10.27 mg/L PBTK NA 50% Human Human -DTXSID7037131 Css NA 97.58 mg/L PBTK NA 95% Human Human -DTXSID7037131 Clint NA 19.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7037131 Vd NA 0.168 L/kg 1compartment NA NA Human Human +DTXSID7037131 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7037131 TK.Half.Life NA 23.89 hours 1compartment NA NA Human Human +DTXSID7037131 Css NA 26.56 mg/L 3compartmentss NA 50% Human Human +DTXSID7037131 Css NA 237.7 mg/L 3compartmentss NA 95% Human Human +DTXSID7037131 Css NA 15.43 mg/L PBTK NA 50% Human Human +DTXSID7037131 Css NA 136.5 mg/L PBTK NA 95% Human Human +DTXSID7037131 Clint 13 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID7037131 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7037131 Vd NA 0.1679 L/kg 1compartment NA NA Rat Human -DTXSID7037131 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7037131 TK.Half.Life NA 10.65 hours 1compartment NA NA Rat Human -DTXSID7037131 Css NA 10.21 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037131 Css NA 72.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037131 Css NA 5.52 mg/L PBTK NA 50% Rat Human -DTXSID7037131 Css NA 39.07 mg/L PBTK NA 95% Rat Human +DTXSID7037131 Vd NA 0.1644 L/kg 1compartment NA NA Rat Human +DTXSID7037131 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7037131 TK.Half.Life NA 15.65 hours 1compartment NA NA Rat Human +DTXSID7037131 Css NA 3.432 mg/L 3compartmentss NA 50% Rat Human +DTXSID7037131 Css NA 25.33 mg/L 3compartmentss NA 95% Rat Human +DTXSID7037131 Css NA 1.922 mg/L PBTK NA 50% Rat Human +DTXSID7037131 Css NA 14.17 mg/L PBTK NA 95% Rat Human DTXSID7037185 Clint 4.537 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID7037185 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID7037185 Clint 4.537 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID7037185 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID7037262 Clint NA 46.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037262 Fup NA 0.092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037262 Vd NA 1.26 L/kg 1compartment NA NA Human Human +DTXSID7037262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037262 Fup 0.0829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037262 Vd NA 1.107 L/kg 1compartment NA NA Human Human DTXSID7037262 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7037262 TK.Half.Life NA 2.272 hours 1compartment NA NA Human Human -DTXSID7037262 Css NA 0.1556 mg/L 3compartmentss NA 50% Human Human -DTXSID7037262 Css NA 1.263 mg/L 3compartmentss NA 95% Human Human -DTXSID7037262 Css NA 0.102 mg/L PBTK NA 50% Human Human -DTXSID7037262 Css NA 0.7926 mg/L PBTK NA 95% Human Human -DTXSID7037262 Clint NA 46.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037262 Fup NA 0.092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037262 Vd NA 0.9709 L/kg 1compartment NA NA Rat Human +DTXSID7037262 TK.Half.Life NA 3.362 hours 1compartment NA NA Human Human +DTXSID7037262 Css NA 0.355 mg/L 3compartmentss NA 50% Human Human +DTXSID7037262 Css NA 2.794 mg/L 3compartmentss NA 95% Human Human +DTXSID7037262 Css NA 0.2264 mg/L PBTK NA 50% Human Human +DTXSID7037262 Css NA 1.711 mg/L PBTK NA 95% Human Human +DTXSID7037262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037262 Fup 0.0829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037262 Vd NA 0.8563 L/kg 1compartment NA NA Rat Human DTXSID7037262 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7037262 TK.Half.Life NA 0.8988 hours 1compartment NA NA Rat Human -DTXSID7037262 Css NA 0.08789 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037262 Css NA 0.5784 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037262 Css NA 0.05392 mg/L PBTK NA 50% Rat Human -DTXSID7037262 Css NA 0.3346 mg/L PBTK NA 95% Rat Human -DTXSID7037478 Clint NA 12.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037478 Fup NA 0.2187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037478 Vd NA 0.9033 L/kg 1compartment NA NA Human Human +DTXSID7037262 TK.Half.Life NA 1.434 hours 1compartment NA NA Rat Human +DTXSID7037262 Css NA 0.04581 mg/L 3compartmentss NA 50% Rat Human +DTXSID7037262 Css NA 0.2738 mg/L 3compartmentss NA 95% Rat Human +DTXSID7037262 Css NA 0.02864 mg/L PBTK NA 50% Rat Human +DTXSID7037262 Css NA 0.1647 mg/L PBTK NA 95% Rat Human +DTXSID7037478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037478 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037478 Vd NA 0.9361 L/kg 1compartment NA NA Human Human DTXSID7037478 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7037478 TK.Half.Life NA 1.887 hours 1compartment NA NA Human Human -DTXSID7037478 Css NA 0.1704 mg/L 3compartmentss NA 50% Human Human -DTXSID7037478 Css NA 1.085 mg/L 3compartmentss NA 95% Human Human -DTXSID7037478 Css NA 0.1199 mg/L PBTK NA 50% Human Human -DTXSID7037478 Css NA 0.7204 mg/L PBTK NA 95% Human Human -DTXSID7037478 Clint NA 12.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037478 Fup NA 0.2187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037478 Vd NA 0.7642 L/kg 1compartment NA NA Rat Human +DTXSID7037478 TK.Half.Life NA 1.37 hours 1compartment NA NA Human Human +DTXSID7037478 Css NA 0.08495 mg/L 3compartmentss NA 50% Human Human +DTXSID7037478 Css NA 0.6329 mg/L 3compartmentss NA 95% Human Human +DTXSID7037478 Css NA 0.0605 mg/L PBTK NA 50% Human Human +DTXSID7037478 Css NA 0.425 mg/L PBTK NA 95% Human Human +DTXSID7037478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037478 Fup 0.247 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037478 Vd NA 0.7969 L/kg 1compartment NA NA Rat Human DTXSID7037478 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7037478 TK.Half.Life NA 0.882 hours 1compartment NA NA Rat Human -DTXSID7037478 Css NA 0.09092 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037478 Css NA 0.4487 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037478 Css NA 0.06125 mg/L PBTK NA 50% Rat Human -DTXSID7037478 Css NA 0.2789 mg/L PBTK NA 95% Rat Human +DTXSID7037478 TK.Half.Life NA 0.6161 hours 1compartment NA NA Rat Human +DTXSID7037478 Css NA 0.01074 mg/L 3compartmentss NA 50% Rat Human +DTXSID7037478 Css NA 0.06038 mg/L 3compartmentss NA 95% Rat Human +DTXSID7037478 Css NA 0.00763 mg/L PBTK NA 50% Rat Human +DTXSID7037478 Css NA 0.04002 mg/L PBTK NA 95% Rat Human DTXSID7037551 Clint 2.89 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7037551 Fup 0.564 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7037551 Vd NA 0.9644 L/kg 1compartment NA NA Human Human DTXSID7037551 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7037551 TK.Half.Life NA 2.385 hours 1compartment NA NA Human Human -DTXSID7037551 Css NA 0.1915 mg/L 3compartmentss NA 50% Human Human -DTXSID7037551 Css NA 0.8598 mg/L 3compartmentss NA 95% Human Human -DTXSID7037551 Css NA 0.162 mg/L PBTK NA 50% Human Human -DTXSID7037551 Css NA 0.6416 mg/L PBTK NA 95% Human Human +DTXSID7037551 Css NA 0.1857 mg/L 3compartmentss NA 50% Human Human +DTXSID7037551 Css NA 0.7853 mg/L 3compartmentss NA 95% Human Human +DTXSID7037551 Css NA 0.1559 mg/L PBTK NA 50% Human Human +DTXSID7037551 Css NA 0.6023 mg/L PBTK NA 95% Human Human DTXSID7037551 Clint 2.89 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7037551 Fup 0.564 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7037551 Vd NA 0.9016 L/kg 1compartment NA NA Rat Human DTXSID7037551 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7037551 TK.Half.Life NA 1.182 hours 1compartment NA NA Rat Human -DTXSID7037551 Css NA 0.08816 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037551 Css NA 0.2653 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037551 Css NA 0.07285 mg/L PBTK NA 50% Rat Human -DTXSID7037551 Css NA 0.1932 mg/L PBTK NA 95% Rat Human -DTXSID7037553 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037553 Fup NA 0.0144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037553 Vd NA 1.051 L/kg 1compartment NA NA Human Human -DTXSID7037553 Days.Css NA 143 Days PBTK NA NA Human Human -DTXSID7037553 TK.Half.Life NA 568.2 hours 1compartment NA NA Human Human -DTXSID7037553 Css NA 88.02 mg/L 3compartmentss NA 50% Human Human -DTXSID7037553 Css NA 494.7 mg/L 3compartmentss NA 95% Human Human -DTXSID7037553 Css NA 53.15 mg/L PBTK NA 50% Human Human -DTXSID7037553 Css NA 291.6 mg/L PBTK NA 95% Human Human -DTXSID7037553 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037553 Fup NA 0.0144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037553 Vd NA 0.7764 L/kg 1compartment NA NA Rat Human -DTXSID7037553 Days.Css NA 32 Days PBTK NA NA Rat Human -DTXSID7037553 TK.Half.Life NA 124.6 hours 1compartment NA NA Rat Human -DTXSID7037553 Css NA 24.95 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037553 Css NA 121.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037553 Css NA 14.16 mg/L PBTK NA 50% Rat Human -DTXSID7037553 Css NA 66.43 mg/L PBTK NA 95% Rat Human -DTXSID7037555 Clint NA 144.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037555 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037555 Vd NA 3.21 L/kg 1compartment NA NA Human Human -DTXSID7037555 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7037555 TK.Half.Life NA 17.18 hours 1compartment NA NA Human Human -DTXSID7037555 Css NA 0.5354 mg/L 3compartmentss NA 50% Human Human -DTXSID7037555 Css NA 3.144 mg/L 3compartmentss NA 95% Human Human -DTXSID7037555 Css NA 0.3756 mg/L PBTK NA 50% Human Human -DTXSID7037555 Css NA 2.182 mg/L PBTK NA 95% Human Human -DTXSID7037555 Clint NA 144.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037555 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037555 Vd NA 2.407 L/kg 1compartment NA NA Rat Human -DTXSID7037555 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7037555 TK.Half.Life NA 2.889 hours 1compartment NA NA Rat Human -DTXSID7037555 Css NA 0.3082 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037555 Css NA 1.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037555 Css NA 0.2063 mg/L PBTK NA 50% Rat Human -DTXSID7037555 Css NA 0.8551 mg/L PBTK NA 95% Rat Human -DTXSID7037680 Clint NA 4.199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7037551 Css NA 0.01997 mg/L 3compartmentss NA 50% Rat Human +DTXSID7037551 Css NA 0.06105 mg/L 3compartmentss NA 95% Rat Human +DTXSID7037551 Css NA 0.01695 mg/L PBTK NA 50% Rat Human +DTXSID7037551 Css NA 0.04546 mg/L PBTK NA 95% Rat Human +DTXSID7037553 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037553 Fup 0.0158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037553 Vd NA 1.099 L/kg 1compartment NA NA Human Human +DTXSID7037553 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7037553 TK.Half.Life NA 36.4 hours 1compartment NA NA Human Human +DTXSID7037553 Css NA 5.676 mg/L 3compartmentss NA 50% Human Human +DTXSID7037553 Css NA 45.96 mg/L 3compartmentss NA 95% Human Human +DTXSID7037553 Css NA 3.462 mg/L PBTK NA 50% Human Human +DTXSID7037553 Css NA 27.13 mg/L PBTK NA 95% Human Human +DTXSID7037553 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037553 Fup 0.0158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037553 Vd NA 0.8127 L/kg 1compartment NA NA Rat Human +DTXSID7037553 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7037553 TK.Half.Life NA 15.12 hours 1compartment NA NA Rat Human +DTXSID7037553 Css NA 0.7087 mg/L 3compartmentss NA 50% Rat Human +DTXSID7037553 Css NA 4.458 mg/L 3compartmentss NA 95% Rat Human +DTXSID7037553 Css NA 0.4186 mg/L PBTK NA 50% Rat Human +DTXSID7037553 Css NA 2.568 mg/L PBTK NA 95% Rat Human +DTXSID7037555 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037555 Fup 0.00893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037555 Vd NA 3.043 L/kg 1compartment NA NA Human Human +DTXSID7037555 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID7037555 TK.Half.Life NA 81.82 hours 1compartment NA NA Human Human +DTXSID7037555 Css NA 3.303 mg/L 3compartmentss NA 50% Human Human +DTXSID7037555 Css NA 20.78 mg/L 3compartmentss NA 95% Human Human +DTXSID7037555 Css NA 2.272 mg/L PBTK NA 50% Human Human +DTXSID7037555 Css NA 13.9 mg/L PBTK NA 95% Human Human +DTXSID7037555 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037555 Fup 0.00893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037555 Vd NA 2.278 L/kg 1compartment NA NA Rat Human +DTXSID7037555 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID7037555 TK.Half.Life NA 12.2 hours 1compartment NA NA Rat Human +DTXSID7037555 Css NA 0.431 mg/L 3compartmentss NA 50% Rat Human +DTXSID7037555 Css NA 2.385 mg/L 3compartmentss NA 95% Rat Human +DTXSID7037555 Css NA 0.2918 mg/L PBTK NA 50% Rat Human +DTXSID7037555 Css NA 1.573 mg/L PBTK NA 95% Rat Human +DTXSID7037680 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7037680 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7037680 Vd NA 0.2754 L/kg 1compartment NA NA Human Human DTXSID7037680 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7037680 TK.Half.Life NA 1.912 hours 1compartment NA NA Human Human -DTXSID7037680 Css NA 1.014 mg/L 3compartmentss NA 50% Human Human -DTXSID7037680 Css NA 6.641 mg/L 3compartmentss NA 95% Human Human -DTXSID7037680 Css NA 0.625 mg/L PBTK NA 50% Human Human -DTXSID7037680 Css NA 3.942 mg/L PBTK NA 95% Human Human -DTXSID7037680 Clint NA 4.199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7037680 TK.Half.Life NA 1.413 hours 1compartment NA NA Human Human +DTXSID7037680 Css NA 0.375 mg/L 3compartmentss NA 50% Human Human +DTXSID7037680 Css NA 2.823 mg/L 3compartmentss NA 95% Human Human +DTXSID7037680 Css NA 0.2327 mg/L PBTK NA 50% Human Human +DTXSID7037680 Css NA 1.694 mg/L PBTK NA 95% Human Human +DTXSID7037680 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7037680 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7037680 Vd NA 0.5813 L/kg 1compartment NA NA Rat Human DTXSID7037680 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7037680 TK.Half.Life NA 0.6102 hours 1compartment NA NA Rat Human -DTXSID7037680 Css NA 0.08306 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037680 Css NA 0.5955 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037680 Css NA 0.0608 mg/L PBTK NA 50% Rat Human -DTXSID7037680 Css NA 0.3521 mg/L PBTK NA 95% Rat Human -DTXSID7037684 Clint NA 5.983 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037684 Fup NA 0.3839 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037684 Vd NA 2.422 L/kg 1compartment NA NA Human Human -DTXSID7037684 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7037684 TK.Half.Life NA 4.148 hours 1compartment NA NA Human Human -DTXSID7037684 Css NA 0.1036 mg/L 3compartmentss NA 50% Human Human -DTXSID7037684 Css NA 0.7922 mg/L 3compartmentss NA 95% Human Human -DTXSID7037684 Css NA 0.1164 mg/L PBTK NA 50% Human Human -DTXSID7037684 Css NA 0.6818 mg/L PBTK NA 95% Human Human -DTXSID7037684 Clint NA 5.983 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037684 Fup NA 0.3839 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037684 Vd NA 2.384 L/kg 1compartment NA NA Rat Human -DTXSID7037684 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7037684 TK.Half.Life NA 2.384 hours 1compartment NA NA Rat Human -DTXSID7037684 Css NA 0.05069 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037684 Css NA 0.3188 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037684 Css NA 0.05714 mg/L PBTK NA 50% Rat Human -DTXSID7037684 Css NA 0.2487 mg/L PBTK NA 95% Rat Human -DTXSID7037715 Clint NA 18.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037715 Fup NA 0.0517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7037715 Vd NA 2.394 L/kg 1compartment NA NA Human Human -DTXSID7037715 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7037715 TK.Half.Life NA 17.74 hours 1compartment NA NA Human Human -DTXSID7037715 Css NA 0.9921 mg/L 3compartmentss NA 50% Human Human -DTXSID7037715 Css NA 6.398 mg/L 3compartmentss NA 95% Human Human -DTXSID7037715 Css NA 0.6662 mg/L PBTK NA 50% Human Human -DTXSID7037715 Css NA 4.122 mg/L PBTK NA 95% Human Human -DTXSID7037715 Clint NA 18.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037715 Fup NA 0.0517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7037715 Vd NA 1.794 L/kg 1compartment NA NA Rat Human +DTXSID7037680 TK.Half.Life NA 0.4888 hours 1compartment NA NA Rat Human +DTXSID7037680 Css NA 0.0005364 mg/L 3compartmentss NA 50% Rat Human +DTXSID7037680 Css NA 0.005367 mg/L 3compartmentss NA 95% Rat Human +DTXSID7037680 Css NA 0.0003948 mg/L PBTK NA 50% Rat Human +DTXSID7037680 Css NA 0.003283 mg/L PBTK NA 95% Rat Human +DTXSID7037715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037715 Fup 0.0652 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7037715 Vd NA 2.33 L/kg 1compartment NA NA Human Human +DTXSID7037715 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7037715 TK.Half.Life NA 12.34 hours 1compartment NA NA Human Human +DTXSID7037715 Css NA 0.6284 mg/L 3compartmentss NA 50% Human Human +DTXSID7037715 Css NA 4.077 mg/L 3compartmentss NA 95% Human Human +DTXSID7037715 Css NA 0.4208 mg/L PBTK NA 50% Human Human +DTXSID7037715 Css NA 2.637 mg/L PBTK NA 95% Human Human +DTXSID7037715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037715 Fup 0.0652 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7037715 Vd NA 1.75 L/kg 1compartment NA NA Rat Human DTXSID7037715 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7037715 TK.Half.Life NA 4.764 hours 1compartment NA NA Rat Human -DTXSID7037715 Css NA 0.545 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037715 Css NA 2.912 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037715 Css NA 0.3469 mg/L PBTK NA 50% Rat Human -DTXSID7037715 Css NA 1.778 mg/L PBTK NA 95% Rat Human +DTXSID7037715 TK.Half.Life NA 3.485 hours 1compartment NA NA Rat Human +DTXSID7037715 Css NA 0.08115 mg/L 3compartmentss NA 50% Rat Human +DTXSID7037715 Css NA 0.4274 mg/L 3compartmentss NA 95% Rat Human +DTXSID7037715 Css NA 0.05377 mg/L PBTK NA 50% Rat Human +DTXSID7037715 Css NA 0.2764 mg/L PBTK NA 95% Rat Human DTXSID7037717 Clint 125 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7037717 Fup 0.00685 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7037717 Vd NA 1.502 L/kg 1compartment NA NA Human Human +DTXSID7037717 Vd NA 0.4121 L/kg 1compartment NA NA Human Human DTXSID7037717 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7037717 TK.Half.Life NA 5.805 hours 1compartment NA NA Human Human -DTXSID7037717 Css NA 0.3764 mg/L 3compartmentss NA 50% Human Human -DTXSID7037717 Css NA 2.751 mg/L 3compartmentss NA 95% Human Human -DTXSID7037717 Css NA 0.2384 mg/L PBTK NA 50% Human Human -DTXSID7037717 Css NA 1.697 mg/L PBTK NA 95% Human Human +DTXSID7037717 TK.Half.Life NA 1.886 hours 1compartment NA NA Human Human +DTXSID7037717 Css NA 0.4188 mg/L 3compartmentss NA 50% Human Human +DTXSID7037717 Css NA 3.351 mg/L 3compartmentss NA 95% Human Human +DTXSID7037717 Css NA 0.2486 mg/L PBTK NA 50% Human Human +DTXSID7037717 Css NA 1.942 mg/L PBTK NA 95% Human Human DTXSID7037717 Clint 125 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7037717 Fup 0.00685 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7037717 Vd NA 1.106 L/kg 1compartment NA NA Rat Human +DTXSID7037717 Vd NA 0.32 L/kg 1compartment NA NA Rat Human DTXSID7037717 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7037717 TK.Half.Life NA 2.211 hours 1compartment NA NA Rat Human -DTXSID7037717 Css NA 0.2122 mg/L 3compartmentss NA 50% Rat Human -DTXSID7037717 Css NA 1.295 mg/L 3compartmentss NA 95% Rat Human -DTXSID7037717 Css NA 0.1267 mg/L PBTK NA 50% Rat Human -DTXSID7037717 Css NA 0.7507 mg/L PBTK NA 95% Rat Human -DTXSID7038317 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7038317 Fup NA 0.0211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7038317 Vd NA 0.7531 L/kg 1compartment NA NA Human Human -DTXSID7038317 Days.Css NA 60 Days PBTK NA NA Human Human -DTXSID7038317 TK.Half.Life NA 253.4 hours 1compartment NA NA Human Human -DTXSID7038317 Css NA 55.79 mg/L 3compartmentss NA 50% Human Human -DTXSID7038317 Css NA 322.9 mg/L 3compartmentss NA 95% Human Human -DTXSID7038317 Css NA 33.74 mg/L PBTK NA 50% Human Human -DTXSID7038317 Css NA 188.7 mg/L PBTK NA 95% Human Human -DTXSID7038317 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7038317 Fup NA 0.0211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7038317 Vd NA 0.5674 L/kg 1compartment NA NA Rat Human -DTXSID7038317 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID7038317 TK.Half.Life NA 60.64 hours 1compartment NA NA Rat Human -DTXSID7038317 Css NA 15.96 mg/L 3compartmentss NA 50% Rat Human -DTXSID7038317 Css NA 78.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID7038317 Css NA 8.979 mg/L PBTK NA 50% Rat Human -DTXSID7038317 Css NA 42.99 mg/L PBTK NA 95% Rat Human -DTXSID7038814 Clint NA 2.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7038814 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7038814 Vd NA 0.8662 L/kg 1compartment NA NA Human Human +DTXSID7037717 TK.Half.Life NA 0.744 hours 1compartment NA NA Rat Human +DTXSID7037717 Css NA 0.04269 mg/L 3compartmentss NA 50% Rat Human +DTXSID7037717 Css NA 0.3059 mg/L 3compartmentss NA 95% Rat Human +DTXSID7037717 Css NA 0.02442 mg/L PBTK NA 50% Rat Human +DTXSID7037717 Css NA 0.1727 mg/L PBTK NA 95% Rat Human +DTXSID7038317 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7038317 Fup 0.0879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7038317 Vd NA 2.144 L/kg 1compartment NA NA Human Human +DTXSID7038317 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7038317 TK.Half.Life NA 7.127 hours 1compartment NA NA Human Human +DTXSID7038317 Css NA 0.3612 mg/L 3compartmentss NA 50% Human Human +DTXSID7038317 Css NA 2.639 mg/L 3compartmentss NA 95% Human Human +DTXSID7038317 Css NA 0.2537 mg/L PBTK NA 50% Human Human +DTXSID7038317 Css NA 1.74 mg/L PBTK NA 95% Human Human +DTXSID7038317 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7038317 Fup 0.0879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7038317 Vd NA 1.738 L/kg 1compartment NA NA Rat Human +DTXSID7038317 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7038317 TK.Half.Life NA 2.71 hours 1compartment NA NA Rat Human +DTXSID7038317 Css NA 0.04644 mg/L 3compartmentss NA 50% Rat Human +DTXSID7038317 Css NA 0.2742 mg/L 3compartmentss NA 95% Rat Human +DTXSID7038317 Css NA 0.03239 mg/L PBTK NA 50% Rat Human +DTXSID7038317 Css NA 0.1791 mg/L PBTK NA 95% Rat Human +DTXSID7038814 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7038814 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7038814 Vd NA 0.6711 L/kg 1compartment NA NA Human Human DTXSID7038814 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7038814 TK.Half.Life NA 1.578 hours 1compartment NA NA Human Human -DTXSID7038814 Css NA 0.1926 mg/L 3compartmentss NA 50% Human Human -DTXSID7038814 Css NA 1.431 mg/L 3compartmentss NA 95% Human Human -DTXSID7038814 Css NA 0.1638 mg/L PBTK NA 50% Human Human -DTXSID7038814 Css NA 0.9792 mg/L PBTK NA 95% Human Human -DTXSID7038814 Clint NA 2.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7038814 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7038814 Vd NA 0.8913 L/kg 1compartment NA NA Rat Human +DTXSID7038814 TK.Half.Life NA 6.633 hours 1compartment NA NA Human Human +DTXSID7038814 Css NA 1.13 mg/L 3compartmentss NA 50% Human Human +DTXSID7038814 Css NA 7.55 mg/L 3compartmentss NA 95% Human Human +DTXSID7038814 Css NA 0.9014 mg/L PBTK NA 50% Human Human +DTXSID7038814 Css NA 4.734 mg/L PBTK NA 95% Human Human +DTXSID7038814 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7038814 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7038814 Vd NA 0.6897 L/kg 1compartment NA NA Rat Human DTXSID7038814 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7038814 TK.Half.Life NA 0.8325 hours 1compartment NA NA Rat Human -DTXSID7038814 Css NA 0.08002 mg/L 3compartmentss NA 50% Rat Human -DTXSID7038814 Css NA 0.5289 mg/L 3compartmentss NA 95% Rat Human -DTXSID7038814 Css NA 0.06792 mg/L PBTK NA 50% Rat Human -DTXSID7038814 Css NA 0.3234 mg/L PBTK NA 95% Rat Human +DTXSID7038814 TK.Half.Life NA 2.32 hours 1compartment NA NA Rat Human +DTXSID7038814 Css NA 0.06756 mg/L 3compartmentss NA 50% Rat Human +DTXSID7038814 Css NA 0.4276 mg/L 3compartmentss NA 95% Rat Human +DTXSID7038814 Css NA 0.05394 mg/L PBTK NA 50% Rat Human +DTXSID7038814 Css NA 0.2595 mg/L PBTK NA 95% Rat Human +DTXSID7038816 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7038816 Fup 0.0418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7038816 Vd NA 3.123 L/kg 1compartment NA NA Human Human +DTXSID7038816 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID7038816 TK.Half.Life NA 68.43 hours 1compartment NA NA Human Human +DTXSID7038816 Css NA 2.55 mg/L 3compartmentss NA 50% Human Human +DTXSID7038816 Css NA 16.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7038816 Css NA 1.775 mg/L PBTK NA 50% Human Human +DTXSID7038816 Css NA 11.12 mg/L PBTK NA 95% Human Human +DTXSID7038816 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7038816 Fup 0.0418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7038816 Vd NA 2.35 L/kg 1compartment NA NA Rat Human +DTXSID7038816 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID7038816 TK.Half.Life NA 9.696 hours 1compartment NA NA Rat Human +DTXSID7038816 Css NA 0.3346 mg/L 3compartmentss NA 50% Rat Human +DTXSID7038816 Css NA 1.878 mg/L 3compartmentss NA 95% Rat Human +DTXSID7038816 Css NA 0.2313 mg/L PBTK NA 50% Rat Human +DTXSID7038816 Css NA 1.276 mg/L PBTK NA 95% Rat Human DTXSID7038864 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7038864 Fup 0.00513 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7038864 Vd NA 35.84 L/kg 1compartment NA NA Human Human -DTXSID7038864 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID7038864 TK.Half.Life NA 1737000 hours 1compartment NA NA Human Human -DTXSID7038864 Css NA 955.8 mg/L 3compartmentss NA 50% Human Human -DTXSID7038864 Css NA 2434 mg/L 3compartmentss NA 95% Human Human -DTXSID7038864 Css NA 3680 mg/L PBTK NA 50% Human Human -DTXSID7038864 Css NA 7974 mg/L PBTK NA 95% Human Human +DTXSID7038864 Vd NA 27.88 L/kg 1compartment NA NA Human Human +DTXSID7038864 Days.Css NA 16400 Days PBTK NA NA Human Human +DTXSID7038864 TK.Half.Life NA 1351000 hours 1compartment NA NA Human Human +DTXSID7038864 Css NA 1202 mg/L 3compartmentss NA 50% Human Human +DTXSID7038864 Css NA 3009 mg/L 3compartmentss NA 95% Human Human +DTXSID7038864 Css NA 3600 mg/L PBTK NA 50% Human Human +DTXSID7038864 Css NA 7675 mg/L PBTK NA 95% Human Human DTXSID7038864 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7038864 Fup 0.00513 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7038864 Vd NA 29.82 L/kg 1compartment NA NA Rat Human -DTXSID7038864 Days.Css NA 16400 Days PBTK NA NA Rat Human -DTXSID7038864 TK.Half.Life NA 127100 hours 1compartment NA NA Rat Human -DTXSID7038864 Css NA 236.7 mg/L 3compartmentss NA 50% Rat Human -DTXSID7038864 Css NA 406.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID7038864 Css NA 989.8 mg/L PBTK NA 50% Rat Human -DTXSID7038864 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID7040150 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID7040150 Fup 0.001342 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID7040150 Vd NA 0.1637 L/kg 1compartment NA NA Human Human -DTXSID7040150 Days.Css NA 237 Days PBTK NA NA Human Human -DTXSID7040150 TK.Half.Life NA 789.1 hours 1compartment NA NA Human Human -DTXSID7040150 Css NA 850.7 mg/L 3compartmentss NA 50% Human Human -DTXSID7040150 Css NA 4054 mg/L 3compartmentss NA 95% Human Human -DTXSID7040150 Css NA 495.8 mg/L PBTK NA 50% Human Human -DTXSID7040150 Css NA 2350 mg/L PBTK NA 95% Human Human -DTXSID7040150 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID7040150 Fup 0.001342 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID7040150 Vd NA 0.1619 L/kg 1compartment NA NA Rat Human -DTXSID7040150 Days.Css NA 73 Days PBTK NA NA Rat Human -DTXSID7040150 TK.Half.Life NA 266 hours 1compartment NA NA Rat Human -DTXSID7040150 Css NA 243.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040150 Css NA 991.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040150 Css NA 131.8 mg/L PBTK NA 50% Rat Human -DTXSID7040150 Css NA 535.5 mg/L PBTK NA 95% Rat Human -DTXSID7040152 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040152 Fup NA 0.7578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040152 Vd NA 0.5017 L/kg 1compartment NA NA Human Human +DTXSID7038864 Vd NA 22.95 L/kg 1compartment NA NA Rat Human +DTXSID7038864 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID7038864 TK.Half.Life NA 97830 hours 1compartment NA NA Rat Human +DTXSID7038864 Css NA 70.02 mg/L 3compartmentss NA 50% Rat Human +DTXSID7038864 Css NA 119.7 mg/L 3compartmentss NA 95% Rat Human +DTXSID7038864 Css NA 230.8 mg/L PBTK NA 50% Rat Human +DTXSID7038864 Css NA 311.1 mg/L PBTK NA 95% Rat Human +DTXSID7040152 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040152 Fup 0.638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040152 Vd NA 0.4576 L/kg 1compartment NA NA Human Human DTXSID7040152 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040152 TK.Half.Life NA 4.284 hours 1compartment NA NA Human Human -DTXSID7040152 Css NA 1.124 mg/L 3compartmentss NA 50% Human Human -DTXSID7040152 Css NA 6.53 mg/L 3compartmentss NA 95% Human Human -DTXSID7040152 Css NA 0.841 mg/L PBTK NA 50% Human Human -DTXSID7040152 Css NA 4.086 mg/L PBTK NA 95% Human Human -DTXSID7040152 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040152 Fup NA 0.7578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040152 Vd NA 0.5285 L/kg 1compartment NA NA Rat Human +DTXSID7040152 TK.Half.Life NA 4.643 hours 1compartment NA NA Human Human +DTXSID7040152 Css NA 0.6928 mg/L 3compartmentss NA 50% Human Human +DTXSID7040152 Css NA 4.456 mg/L 3compartmentss NA 95% Human Human +DTXSID7040152 Css NA 0.51 mg/L PBTK NA 50% Human Human +DTXSID7040152 Css NA 2.75 mg/L PBTK NA 95% Human Human +DTXSID7040152 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040152 Fup 0.638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040152 Vd NA 0.4813 L/kg 1compartment NA NA Rat Human DTXSID7040152 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040152 TK.Half.Life NA 1.538 hours 1compartment NA NA Rat Human -DTXSID7040152 Css NA 0.2903 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040152 Css NA 1.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040152 Css NA 0.2086 mg/L PBTK NA 50% Rat Human -DTXSID7040152 Css NA 0.966 mg/L PBTK NA 95% Rat Human -DTXSID7040154 Clint NA 13.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040154 Fup NA 0.7494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040154 Vd NA 1.91 L/kg 1compartment NA NA Human Human -DTXSID7040154 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040154 TK.Half.Life NA 1.58 hours 1compartment NA NA Human Human -DTXSID7040154 Css NA 0.04088 mg/L 3compartmentss NA 50% Human Human -DTXSID7040154 Css NA 0.403 mg/L 3compartmentss NA 95% Human Human -DTXSID7040154 Css NA 0.04012 mg/L PBTK NA 50% Human Human -DTXSID7040154 Css NA 0.3091 mg/L PBTK NA 95% Human Human -DTXSID7040154 Clint NA 13.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040154 Fup NA 0.7494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040154 Vd NA 1.933 L/kg 1compartment NA NA Rat Human +DTXSID7040152 TK.Half.Life NA 1.663 hours 1compartment NA NA Rat Human +DTXSID7040152 Css NA 0.003639 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040152 Css NA 0.02487 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040152 Css NA 0.002561 mg/L PBTK NA 50% Rat Human +DTXSID7040152 Css NA 0.01473 mg/L PBTK NA 95% Rat Human +DTXSID7040154 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040154 Fup 0.863 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040154 Vd NA 2.756 L/kg 1compartment NA NA Human Human +DTXSID7040154 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7040154 TK.Half.Life NA 20.67 hours 1compartment NA NA Human Human +DTXSID7040154 Css NA 0.669 mg/L 3compartmentss NA 50% Human Human +DTXSID7040154 Css NA 4.761 mg/L 3compartmentss NA 95% Human Human +DTXSID7040154 Css NA 0.7645 mg/L PBTK NA 50% Human Human +DTXSID7040154 Css NA 3.505 mg/L PBTK NA 95% Human Human +DTXSID7040154 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040154 Fup 0.863 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040154 Vd NA 2.793 L/kg 1compartment NA NA Rat Human DTXSID7040154 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040154 TK.Half.Life NA 0.8348 hours 1compartment NA NA Rat Human -DTXSID7040154 Css NA 0.0199 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040154 Css NA 0.1849 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040154 Css NA 0.01964 mg/L PBTK NA 50% Rat Human -DTXSID7040154 Css NA 0.1275 mg/L PBTK NA 95% Rat Human -DTXSID7040283 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040283 Fup NA 0.0239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040283 Vd NA 2.497 L/kg 1compartment NA NA Human Human -DTXSID7040283 Days.Css NA 587 Days PBTK NA NA Human Human -DTXSID7040283 TK.Half.Life NA 2230 hours 1compartment NA NA Human Human -DTXSID7040283 Css NA 122.4 mg/L 3compartmentss NA 50% Human Human -DTXSID7040283 Css NA 450.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7040283 Css NA 81.31 mg/L PBTK NA 50% Human Human -DTXSID7040283 Css NA 274.5 mg/L PBTK NA 95% Human Human -DTXSID7040283 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040283 Fup NA 0.0239 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040283 Vd NA 1.864 L/kg 1compartment NA NA Rat Human -DTXSID7040283 Days.Css NA 147 Days PBTK NA NA Rat Human -DTXSID7040283 TK.Half.Life NA 266.2 hours 1compartment NA NA Rat Human -DTXSID7040283 Css NA 33.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040283 Css NA 103.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040283 Css NA 21.08 mg/L PBTK NA 50% Rat Human -DTXSID7040283 Css NA 59.22 mg/L PBTK NA 95% Rat Human -DTXSID7040285 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040285 Fup NA 0.4808 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040285 Vd NA 1.584 L/kg 1compartment NA NA Human Human +DTXSID7040154 TK.Half.Life NA 7.136 hours 1compartment NA NA Rat Human +DTXSID7040154 Css NA 0.03814 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040154 Css NA 0.2845 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040154 Css NA 0.04516 mg/L PBTK NA 50% Rat Human +DTXSID7040154 Css NA 0.1993 mg/L PBTK NA 95% Rat Human +DTXSID7040283 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040283 Fup 0.00872 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040283 Vd NA 1.691 L/kg 1compartment NA NA Human Human +DTXSID7040283 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7040283 TK.Half.Life NA 27.9 hours 1compartment NA NA Human Human +DTXSID7040283 Css NA 2.657 mg/L 3compartmentss NA 50% Human Human +DTXSID7040283 Css NA 23.7 mg/L 3compartmentss NA 95% Human Human +DTXSID7040283 Css NA 1.666 mg/L PBTK NA 50% Human Human +DTXSID7040283 Css NA 14.37 mg/L PBTK NA 95% Human Human +DTXSID7040283 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040283 Fup 0.00872 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040283 Vd NA 1.249 L/kg 1compartment NA NA Rat Human +DTXSID7040283 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7040283 TK.Half.Life NA 10.09 hours 1compartment NA NA Rat Human +DTXSID7040283 Css NA 0.3463 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040283 Css NA 2.484 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040283 Css NA 0.2111 mg/L PBTK NA 50% Rat Human +DTXSID7040283 Css NA 1.44 mg/L PBTK NA 95% Rat Human +DTXSID7040285 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040285 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040285 Vd NA 1.17 L/kg 1compartment NA NA Human Human DTXSID7040285 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040285 TK.Half.Life NA 3.299 hours 1compartment NA NA Human Human -DTXSID7040285 Css NA 0.1682 mg/L 3compartmentss NA 50% Human Human -DTXSID7040285 Css NA 1.147 mg/L 3compartmentss NA 95% Human Human -DTXSID7040285 Css NA 0.1397 mg/L PBTK NA 50% Human Human -DTXSID7040285 Css NA 0.8214 mg/L PBTK NA 95% Human Human -DTXSID7040285 Clint NA 5.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040285 Fup NA 0.4808 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040285 Vd NA 1.318 L/kg 1compartment NA NA Rat Human +DTXSID7040285 TK.Half.Life NA 1.661 hours 1compartment NA NA Human Human +DTXSID7040285 Css NA 0.08071 mg/L 3compartmentss NA 50% Human Human +DTXSID7040285 Css NA 0.5864 mg/L 3compartmentss NA 95% Human Human +DTXSID7040285 Css NA 0.05886 mg/L PBTK NA 50% Human Human +DTXSID7040285 Css NA 0.3986 mg/L PBTK NA 95% Human Human +DTXSID7040285 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040285 Fup 0.268 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040285 Vd NA 0.9667 L/kg 1compartment NA NA Rat Human DTXSID7040285 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040285 TK.Half.Life NA 1.348 hours 1compartment NA NA Rat Human -DTXSID7040285 Css NA 0.08378 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040285 Css NA 0.4403 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040285 Css NA 0.06687 mg/L PBTK NA 50% Rat Human -DTXSID7040285 Css NA 0.2886 mg/L PBTK NA 95% Rat Human -DTXSID7040287 Clint NA 313.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040287 Fup NA 0.0302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040287 Vd NA 2.097 L/kg 1compartment NA NA Human Human -DTXSID7040287 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040287 TK.Half.Life NA 2.863 hours 1compartment NA NA Human Human -DTXSID7040287 Css NA 0.08109 mg/L 3compartmentss NA 50% Human Human -DTXSID7040287 Css NA 0.6745 mg/L 3compartmentss NA 95% Human Human -DTXSID7040287 Css NA 0.05283 mg/L PBTK NA 50% Human Human -DTXSID7040287 Css NA 0.4177 mg/L PBTK NA 95% Human Human -DTXSID7040287 Clint NA 313.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040287 Fup NA 0.0302 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040287 Vd NA 1.564 L/kg 1compartment NA NA Rat Human +DTXSID7040285 TK.Half.Life NA 0.7043 hours 1compartment NA NA Rat Human +DTXSID7040285 Css NA 0.01011 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040285 Css NA 0.05427 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040285 Css NA 0.007407 mg/L PBTK NA 50% Rat Human +DTXSID7040285 Css NA 0.03699 mg/L PBTK NA 95% Rat Human +DTXSID7040287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040287 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040287 Vd NA 1.792 L/kg 1compartment NA NA Human Human +DTXSID7040287 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7040287 TK.Half.Life NA 17.99 hours 1compartment NA NA Human Human +DTXSID7040287 Css NA 1.532 mg/L 3compartmentss NA 50% Human Human +DTXSID7040287 Css NA 12.76 mg/L 3compartmentss NA 95% Human Human +DTXSID7040287 Css NA 0.9655 mg/L PBTK NA 50% Human Human +DTXSID7040287 Css NA 7.746 mg/L PBTK NA 95% Human Human +DTXSID7040287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040287 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040287 Vd NA 1.33 L/kg 1compartment NA NA Rat Human DTXSID7040287 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040287 TK.Half.Life NA 0.9203 hours 1compartment NA NA Rat Human -DTXSID7040287 Css NA 0.04702 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040287 Css NA 0.3062 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040287 Css NA 0.02891 mg/L PBTK NA 50% Rat Human -DTXSID7040287 Css NA 0.1805 mg/L PBTK NA 95% Rat Human -DTXSID7040289 Clint NA 0.02457 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040289 Fup NA 0.1371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040289 Vd NA 0.3806 L/kg 1compartment NA NA Human Human -DTXSID7040289 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7040289 TK.Half.Life NA 17.26 hours 1compartment NA NA Human Human -DTXSID7040289 Css NA 6.419 mg/L 3compartmentss NA 50% Human Human -DTXSID7040289 Css NA 30.98 mg/L 3compartmentss NA 95% Human Human -DTXSID7040289 Css NA 4.149 mg/L PBTK NA 50% Human Human -DTXSID7040289 Css NA 18.39 mg/L PBTK NA 95% Human Human -DTXSID7040289 Clint NA 0.02457 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040289 Fup NA 0.1371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040289 Vd NA 0.3799 L/kg 1compartment NA NA Rat Human +DTXSID7040287 TK.Half.Life NA 6.284 hours 1compartment NA NA Rat Human +DTXSID7040287 Css NA 0.1965 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040287 Css NA 1.383 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040287 Css NA 0.1212 mg/L PBTK NA 50% Rat Human +DTXSID7040287 Css NA 0.8201 mg/L PBTK NA 95% Rat Human +DTXSID7040289 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040289 Fup 0.304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040289 Vd NA 0.5762 L/kg 1compartment NA NA Human Human +DTXSID7040289 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7040289 TK.Half.Life NA 0.7328 hours 1compartment NA NA Human Human +DTXSID7040289 Css NA 0.06521 mg/L 3compartmentss NA 50% Human Human +DTXSID7040289 Css NA 0.495 mg/L 3compartmentss NA 95% Human Human +DTXSID7040289 Css NA 0.04772 mg/L PBTK NA 50% Human Human +DTXSID7040289 Css NA 0.3331 mg/L PBTK NA 95% Human Human +DTXSID7040289 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040289 Fup 0.304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040289 Vd NA 0.579 L/kg 1compartment NA NA Rat Human DTXSID7040289 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040289 TK.Half.Life NA 5.991 hours 1compartment NA NA Rat Human -DTXSID7040289 Css NA 1.894 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040289 Css NA 7.678 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040289 Css NA 1.147 mg/L PBTK NA 50% Rat Human -DTXSID7040289 Css NA 4.282 mg/L PBTK NA 95% Rat Human -DTXSID7040316 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040316 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040316 Vd NA 2.012 L/kg 1compartment NA NA Human Human -DTXSID7040316 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7040316 TK.Half.Life NA 17.67 hours 1compartment NA NA Human Human -DTXSID7040316 Css NA 0.7674 mg/L 3compartmentss NA 50% Human Human -DTXSID7040316 Css NA 5.51 mg/L 3compartmentss NA 95% Human Human -DTXSID7040316 Css NA 0.7769 mg/L PBTK NA 50% Human Human -DTXSID7040316 Css NA 3.892 mg/L PBTK NA 95% Human Human -DTXSID7040316 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040316 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040316 Vd NA 1.732 L/kg 1compartment NA NA Rat Human -DTXSID7040316 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040316 TK.Half.Life NA 4.143 hours 1compartment NA NA Rat Human -DTXSID7040316 Css NA 0.1999 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040316 Css NA 1.296 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040316 Css NA 0.1986 mg/L PBTK NA 50% Rat Human -DTXSID7040316 Css NA 0.8389 mg/L PBTK NA 95% Rat Human -DTXSID7040360 Clint NA 11.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040360 Fup NA 0.0229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040360 Vd NA 0.7199 L/kg 1compartment NA NA Human Human -DTXSID7040360 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040360 TK.Half.Life NA 9.634 hours 1compartment NA NA Human Human -DTXSID7040360 Css NA 2.318 mg/L 3compartmentss NA 50% Human Human -DTXSID7040360 Css NA 20.32 mg/L 3compartmentss NA 95% Human Human -DTXSID7040360 Css NA 1.404 mg/L PBTK NA 50% Human Human -DTXSID7040360 Css NA 12.08 mg/L PBTK NA 95% Human Human -DTXSID7040360 Clint NA 11.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040360 Fup NA 0.0229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040360 Vd NA 0.5433 L/kg 1compartment NA NA Rat Human +DTXSID7040289 TK.Half.Life NA 0.3927 hours 1compartment NA NA Rat Human +DTXSID7040289 Css NA 0.008076 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040289 Css NA 0.04625 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040289 Css NA 0.005938 mg/L PBTK NA 50% Rat Human +DTXSID7040289 Css NA 0.03076 mg/L PBTK NA 95% Rat Human +DTXSID7040360 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040360 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040360 Vd NA 1.303 L/kg 1compartment NA NA Human Human +DTXSID7040360 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7040360 TK.Half.Life NA 12.45 hours 1compartment NA NA Human Human +DTXSID7040360 Css NA 1.518 mg/L 3compartmentss NA 50% Human Human +DTXSID7040360 Css NA 13.91 mg/L 3compartmentss NA 95% Human Human +DTXSID7040360 Css NA 0.9351 mg/L PBTK NA 50% Human Human +DTXSID7040360 Css NA 8.408 mg/L PBTK NA 95% Human Human +DTXSID7040360 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040360 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040360 Vd NA 0.9635 L/kg 1compartment NA NA Rat Human DTXSID7040360 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040360 TK.Half.Life NA 4.483 hours 1compartment NA NA Rat Human -DTXSID7040360 Css NA 1.305 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040360 Css NA 9.141 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040360 Css NA 0.7358 mg/L PBTK NA 50% Rat Human -DTXSID7040360 Css NA 4.974 mg/L PBTK NA 95% Rat Human +DTXSID7040360 TK.Half.Life NA 5.048 hours 1compartment NA NA Rat Human +DTXSID7040360 Css NA 0.197 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040360 Css NA 1.434 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040360 Css NA 0.1182 mg/L PBTK NA 50% Rat Human +DTXSID7040360 Css NA 0.8313 mg/L PBTK NA 95% Rat Human DTXSID7040362 Clint 12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID7040362 Fup NA 0.0217 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040362 Vd NA 1.077 L/kg 1compartment NA NA Human Human -DTXSID7040362 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7040362 TK.Half.Life NA 15.19 hours 1compartment NA NA Human Human -DTXSID7040362 Css NA 2.458 mg/L 3compartmentss NA 50% Human Human -DTXSID7040362 Css NA 20.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7040362 Css NA 1.508 mg/L PBTK NA 50% Human Human -DTXSID7040362 Css NA 12.25 mg/L PBTK NA 95% Human Human +DTXSID7040362 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040362 Vd NA 2384 L/kg 1compartment NA NA Human Human +DTXSID7040362 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID7040362 TK.Half.Life NA 105700 hours 1compartment NA NA Human Human +DTXSID7040362 Css NA 0.009903 mg/L 3compartmentss NA 50% Human Human +DTXSID7040362 Css NA 0.09399 mg/L 3compartmentss NA 95% Human Human +DTXSID7040362 Css NA 3.845 mg/L PBTK NA 50% Human Human +DTXSID7040362 Css NA 25.29 mg/L PBTK NA 95% Human Human DTXSID7040362 Clint 12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID7040362 Fup NA 0.0217 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040362 Vd NA 0.7997 L/kg 1compartment NA NA Rat Human -DTXSID7040362 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040362 TK.Half.Life NA 6.49 hours 1compartment NA NA Rat Human -DTXSID7040362 Css NA 1.307 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040362 Css NA 9.205 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040362 Css NA 0.7508 mg/L PBTK NA 50% Rat Human -DTXSID7040362 Css NA 5.075 mg/L PBTK NA 95% Rat Human -DTXSID7040449 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040449 Fup NA 0.2322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040449 Vd NA 0.3085 L/kg 1compartment NA NA Human Human -DTXSID7040449 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040449 TK.Half.Life NA 8.595 hours 1compartment NA NA Human Human -DTXSID7040449 Css NA 3.495 mg/L 3compartmentss NA 50% Human Human -DTXSID7040449 Css NA 12.71 mg/L 3compartmentss NA 95% Human Human -DTXSID7040449 Css NA 2.274 mg/L PBTK NA 50% Human Human -DTXSID7040449 Css NA 7.745 mg/L PBTK NA 95% Human Human -DTXSID7040449 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040449 Fup NA 0.2322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040449 Vd NA 0.3297 L/kg 1compartment NA NA Rat Human -DTXSID7040449 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040449 TK.Half.Life NA 3.131 hours 1compartment NA NA Rat Human -DTXSID7040449 Css NA 0.9746 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040449 Css NA 2.962 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040449 Css NA 0.5976 mg/L PBTK NA 50% Rat Human -DTXSID7040449 Css NA 1.677 mg/L PBTK NA 95% Rat Human -DTXSID7040526 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040526 Fup NA 0.8339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040526 Vd NA 0.7108 L/kg 1compartment NA NA Human Human +DTXSID7040362 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040362 Vd NA 2212 L/kg 1compartment NA NA Rat Human +DTXSID7040362 Days.Css NA 8526 Days PBTK NA NA Rat Human +DTXSID7040362 TK.Half.Life NA 18770 hours 1compartment NA NA Rat Human +DTXSID7040362 Css NA 0.001109 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040362 Css NA 0.008541 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040362 Css NA 0.4946 mg/L PBTK NA 50% Rat Human +DTXSID7040362 Css NA 2.652 mg/L PBTK NA 95% Rat Human +DTXSID7040526 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040526 Fup 0.863 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040526 Vd NA 0.8057 L/kg 1compartment NA NA Human Human DTXSID7040526 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040526 TK.Half.Life NA 5.519 hours 1compartment NA NA Human Human -DTXSID7040526 Css NA 0.9772 mg/L 3compartmentss NA 50% Human Human -DTXSID7040526 Css NA 5.61 mg/L 3compartmentss NA 95% Human Human -DTXSID7040526 Css NA 0.7973 mg/L PBTK NA 50% Human Human -DTXSID7040526 Css NA 3.614 mg/L PBTK NA 95% Human Human -DTXSID7040526 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040526 Fup NA 0.8339 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040526 Vd NA 0.7413 L/kg 1compartment NA NA Rat Human +DTXSID7040526 TK.Half.Life NA 6.059 hours 1compartment NA NA Human Human +DTXSID7040526 Css NA 0.5105 mg/L 3compartmentss NA 50% Human Human +DTXSID7040526 Css NA 3.172 mg/L 3compartmentss NA 95% Human Human +DTXSID7040526 Css NA 0.4296 mg/L PBTK NA 50% Human Human +DTXSID7040526 Css NA 2.055 mg/L PBTK NA 95% Human Human +DTXSID7040526 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040526 Fup 0.863 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040526 Vd NA 0.8252 L/kg 1compartment NA NA Rat Human DTXSID7040526 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040526 TK.Half.Life NA 1.96 hours 1compartment NA NA Rat Human -DTXSID7040526 Css NA 0.2521 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040526 Css NA 1.459 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040526 Css NA 0.1994 mg/L PBTK NA 50% Rat Human -DTXSID7040526 Css NA 0.8714 mg/L PBTK NA 95% Rat Human +DTXSID7040526 TK.Half.Life NA 2.11 hours 1compartment NA NA Rat Human +DTXSID7040526 Css NA 0.002611 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040526 Css NA 0.01643 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040526 Css NA 0.002142 mg/L PBTK NA 50% Rat Human +DTXSID7040526 Css NA 0.01062 mg/L PBTK NA 95% Rat Human DTXSID7040609 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7040609 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040609 Vd NA 1.464 L/kg 1compartment NA NA Human Human +DTXSID7040609 Vd NA 1.554 L/kg 1compartment NA NA Human Human DTXSID7040609 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7040609 TK.Half.Life NA 10.4 hours 1compartment NA NA Human Human -DTXSID7040609 Css NA 0.7346 mg/L 3compartmentss NA 50% Human Human -DTXSID7040609 Css NA 5.487 mg/L 3compartmentss NA 95% Human Human -DTXSID7040609 Css NA 0.7082 mg/L PBTK NA 50% Human Human -DTXSID7040609 Css NA 3.737 mg/L PBTK NA 95% Human Human +DTXSID7040609 TK.Half.Life NA 11.32 hours 1compartment NA NA Human Human +DTXSID7040609 Css NA 0.722 mg/L 3compartmentss NA 50% Human Human +DTXSID7040609 Css NA 5.541 mg/L 3compartmentss NA 95% Human Human +DTXSID7040609 Css NA 0.6976 mg/L PBTK NA 50% Human Human +DTXSID7040609 Css NA 3.752 mg/L PBTK NA 95% Human Human DTXSID7040609 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7040609 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040609 Vd NA 1.353 L/kg 1compartment NA NA Rat Human +DTXSID7040609 Vd NA 1.417 L/kg 1compartment NA NA Rat Human DTXSID7040609 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040609 TK.Half.Life NA 3.052 hours 1compartment NA NA Rat Human -DTXSID7040609 Css NA 0.1883 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040609 Css NA 1.291 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040609 Css NA 0.1783 mg/L PBTK NA 50% Rat Human -DTXSID7040609 Css NA 0.8126 mg/L PBTK NA 95% Rat Human -DTXSID7040651 Clint NA 7.198 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040651 Fup NA 0.1189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040651 Vd NA 2.652 L/kg 1compartment NA NA Human Human -DTXSID7040651 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7040651 TK.Half.Life NA 30.85 hours 1compartment NA NA Human Human -DTXSID7040651 Css NA 1.469 mg/L 3compartmentss NA 50% Human Human -DTXSID7040651 Css NA 8.301 mg/L 3compartmentss NA 95% Human Human -DTXSID7040651 Css NA 1.023 mg/L PBTK NA 50% Human Human -DTXSID7040651 Css NA 5.462 mg/L PBTK NA 95% Human Human -DTXSID7040651 Clint NA 7.198 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040651 Fup NA 0.1189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040651 Vd NA 2.001 L/kg 1compartment NA NA Rat Human -DTXSID7040651 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7040651 TK.Half.Life NA 6.849 hours 1compartment NA NA Rat Human -DTXSID7040651 Css NA 0.783 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040651 Css NA 3.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040651 Css NA 0.5208 mg/L PBTK NA 50% Rat Human -DTXSID7040651 Css NA 2.053 mg/L PBTK NA 95% Rat Human -DTXSID7040653 Clint NA 13.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040653 Fup NA 0.0313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040653 Vd NA 0.1886 L/kg 1compartment NA NA Human Human +DTXSID7040609 TK.Half.Life NA 3.218 hours 1compartment NA NA Rat Human +DTXSID7040609 Css NA 0.04172 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040609 Css NA 0.2867 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040609 Css NA 0.0416 mg/L PBTK NA 50% Rat Human +DTXSID7040609 Css NA 0.1882 mg/L PBTK NA 95% Rat Human +DTXSID7040651 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040651 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040651 Vd NA 2.904 L/kg 1compartment NA NA Human Human +DTXSID7040651 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7040651 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human +DTXSID7040651 Css NA 0.3822 mg/L 3compartmentss NA 50% Human Human +DTXSID7040651 Css NA 2.389 mg/L 3compartmentss NA 95% Human Human +DTXSID7040651 Css NA 0.2749 mg/L PBTK NA 50% Human Human +DTXSID7040651 Css NA 1.635 mg/L PBTK NA 95% Human Human +DTXSID7040651 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040651 Fup 0.24 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040651 Vd NA 2.197 L/kg 1compartment NA NA Rat Human +DTXSID7040651 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7040651 TK.Half.Life NA 2.417 hours 1compartment NA NA Rat Human +DTXSID7040651 Css NA 0.04861 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040651 Css NA 0.2411 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040651 Css NA 0.03493 mg/L PBTK NA 50% Rat Human +DTXSID7040651 Css NA 0.167 mg/L PBTK NA 95% Rat Human +DTXSID7040653 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040653 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040653 Vd NA 0.3219 L/kg 1compartment NA NA Human Human DTXSID7040653 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040653 TK.Half.Life NA 1.701 hours 1compartment NA NA Human Human -DTXSID7040653 Css NA 1.541 mg/L 3compartmentss NA 50% Human Human -DTXSID7040653 Css NA 14.81 mg/L 3compartmentss NA 95% Human Human -DTXSID7040653 Css NA 0.9074 mg/L PBTK NA 50% Human Human -DTXSID7040653 Css NA 8.55 mg/L PBTK NA 95% Human Human -DTXSID7040653 Clint NA 13.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040653 Fup NA 0.0313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040653 Vd NA 0.1886 L/kg 1compartment NA NA Rat Human +DTXSID7040653 TK.Half.Life NA 1.432 hours 1compartment NA NA Human Human +DTXSID7040653 Css NA 0.2955 mg/L 3compartmentss NA 50% Human Human +DTXSID7040653 Css NA 2.177 mg/L 3compartmentss NA 95% Human Human +DTXSID7040653 Css NA 0.1886 mg/L PBTK NA 50% Human Human +DTXSID7040653 Css NA 1.324 mg/L PBTK NA 95% Human Human +DTXSID7040653 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040653 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040653 Vd NA 0.3228 L/kg 1compartment NA NA Rat Human DTXSID7040653 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040653 TK.Half.Life NA 1.101 hours 1compartment NA NA Rat Human -DTXSID7040653 Css NA 0.8776 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040653 Css NA 6.146 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040653 Css NA 0.4826 mg/L PBTK NA 50% Rat Human -DTXSID7040653 Css NA 3.326 mg/L PBTK NA 95% Rat Human -DTXSID7040657 Clint NA 56.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040657 Fup NA 0.0141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040657 Vd NA 3.089 L/kg 1compartment NA NA Human Human +DTXSID7040653 TK.Half.Life NA 0.8583 hours 1compartment NA NA Rat Human +DTXSID7040653 Css NA 0.002955 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040653 Css NA 0.01853 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040653 Css NA 0.001781 mg/L PBTK NA 50% Rat Human +DTXSID7040653 Css NA 0.01069 mg/L PBTK NA 95% Rat Human +DTXSID7040655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040655 Fup 0.0011 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7040655 Vd NA 0.1646 L/kg 1compartment NA NA Human Human +DTXSID7040655 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID7040655 TK.Half.Life NA 26.12 hours 1compartment NA NA Human Human +DTXSID7040655 Css NA 29.8 mg/L 3compartmentss NA 50% Human Human +DTXSID7040655 Css NA 263.9 mg/L 3compartmentss NA 95% Human Human +DTXSID7040655 Css NA 17.32 mg/L PBTK NA 50% Human Human +DTXSID7040655 Css NA 152.9 mg/L PBTK NA 95% Human Human +DTXSID7040655 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040655 Fup 0.0011 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7040655 Vd NA 0.162 L/kg 1compartment NA NA Rat Human +DTXSID7040655 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7040655 TK.Half.Life NA 17.51 hours 1compartment NA NA Rat Human +DTXSID7040655 Css NA 3.904 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040655 Css NA 28.31 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040655 Css NA 2.188 mg/L PBTK NA 50% Rat Human +DTXSID7040655 Css NA 15.84 mg/L PBTK NA 95% Rat Human +DTXSID7040657 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040657 Fup 0.0521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040657 Vd NA 3.228 L/kg 1compartment NA NA Human Human DTXSID7040657 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040657 TK.Half.Life NA 12.04 hours 1compartment NA NA Human Human -DTXSID7040657 Css NA 0.3942 mg/L 3compartmentss NA 50% Human Human -DTXSID7040657 Css NA 2.702 mg/L 3compartmentss NA 95% Human Human -DTXSID7040657 Css NA 0.2739 mg/L PBTK NA 50% Human Human -DTXSID7040657 Css NA 1.779 mg/L PBTK NA 95% Human Human -DTXSID7040657 Clint NA 56.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040657 Fup NA 0.0141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040657 Vd NA 2.328 L/kg 1compartment NA NA Rat Human +DTXSID7040657 TK.Half.Life NA 11.6 hours 1compartment NA NA Human Human +DTXSID7040657 Css NA 0.3321 mg/L 3compartmentss NA 50% Human Human +DTXSID7040657 Css NA 2.413 mg/L 3compartmentss NA 95% Human Human +DTXSID7040657 Css NA 0.2394 mg/L PBTK NA 50% Human Human +DTXSID7040657 Css NA 1.66 mg/L PBTK NA 95% Human Human +DTXSID7040657 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040657 Fup 0.0521 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040657 Vd NA 2.481 L/kg 1compartment NA NA Rat Human DTXSID7040657 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040657 TK.Half.Life NA 2.205 hours 1compartment NA NA Rat Human -DTXSID7040657 Css NA 0.224 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040657 Css NA 1.187 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040657 Css NA 0.1485 mg/L PBTK NA 50% Rat Human -DTXSID7040657 Css NA 0.7657 mg/L PBTK NA 95% Rat Human -DTXSID7040732 Clint NA 4.579 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040732 Fup NA 0.2097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040732 Vd NA 1.085 L/kg 1compartment NA NA Human Human +DTXSID7040657 TK.Half.Life NA 2.179 hours 1compartment NA NA Rat Human +DTXSID7040657 Css NA 0.04328 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040657 Css NA 0.2539 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040657 Css NA 0.03085 mg/L PBTK NA 50% Rat Human +DTXSID7040657 Css NA 0.1767 mg/L PBTK NA 95% Rat Human +DTXSID7040732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040732 Fup 0.0774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040732 Vd NA 1.893 L/kg 1compartment NA NA Human Human DTXSID7040732 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040732 TK.Half.Life NA 4.851 hours 1compartment NA NA Human Human -DTXSID7040732 Css NA 0.47 mg/L 3compartmentss NA 50% Human Human -DTXSID7040732 Css NA 2.542 mg/L 3compartmentss NA 95% Human Human -DTXSID7040732 Css NA 0.3338 mg/L PBTK NA 50% Human Human -DTXSID7040732 Css NA 1.665 mg/L PBTK NA 95% Human Human -DTXSID7040732 Clint NA 4.579 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040732 Fup NA 0.2097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040732 Vd NA 0.8901 L/kg 1compartment NA NA Rat Human +DTXSID7040732 TK.Half.Life NA 7.226 hours 1compartment NA NA Human Human +DTXSID7040732 Css NA 0.4494 mg/L 3compartmentss NA 50% Human Human +DTXSID7040732 Css NA 3.109 mg/L 3compartmentss NA 95% Human Human +DTXSID7040732 Css NA 0.301 mg/L PBTK NA 50% Human Human +DTXSID7040732 Css NA 1.973 mg/L PBTK NA 95% Human Human +DTXSID7040732 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040732 Fup 0.0774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040732 Vd NA 1.428 L/kg 1compartment NA NA Rat Human DTXSID7040732 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040732 TK.Half.Life NA 2.151 hours 1compartment NA NA Rat Human -DTXSID7040732 Css NA 0.2378 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040732 Css NA 0.9338 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040732 Css NA 0.1613 mg/L PBTK NA 50% Rat Human -DTXSID7040732 Css NA 0.5732 mg/L PBTK NA 95% Rat Human -DTXSID7040734 Clint NA 17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040734 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040734 Vd NA 2.247 L/kg 1compartment NA NA Human Human -DTXSID7040734 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7040734 TK.Half.Life NA 32.42 hours 1compartment NA NA Human Human -DTXSID7040734 Css NA 2.168 mg/L 3compartmentss NA 50% Human Human -DTXSID7040734 Css NA 16.76 mg/L 3compartmentss NA 95% Human Human -DTXSID7040734 Css NA 1.417 mg/L PBTK NA 50% Human Human -DTXSID7040734 Css NA 10.34 mg/L PBTK NA 95% Human Human -DTXSID7040734 Clint NA 17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040734 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040734 Vd NA 1.673 L/kg 1compartment NA NA Rat Human -DTXSID7040734 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7040734 TK.Half.Life NA 9.219 hours 1compartment NA NA Rat Human -DTXSID7040734 Css NA 1.199 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040734 Css NA 7.675 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040734 Css NA 0.7378 mg/L PBTK NA 50% Rat Human -DTXSID7040734 Css NA 4.568 mg/L PBTK NA 95% Rat Human -DTXSID7040736 Clint NA 152.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040736 Fup NA 0.0342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040736 Vd NA 0.7682 L/kg 1compartment NA NA Human Human +DTXSID7040732 TK.Half.Life NA 2.476 hours 1compartment NA NA Rat Human +DTXSID7040732 Css NA 0.0581 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040732 Css NA 0.3242 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040732 Css NA 0.03792 mg/L PBTK NA 50% Rat Human +DTXSID7040732 Css NA 0.2015 mg/L PBTK NA 95% Rat Human +DTXSID7040734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040734 Fup 0.0306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040734 Vd NA 2.426 L/kg 1compartment NA NA Human Human +DTXSID7040734 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7040734 TK.Half.Life NA 22.48 hours 1compartment NA NA Human Human +DTXSID7040734 Css NA 1.26 mg/L 3compartmentss NA 50% Human Human +DTXSID7040734 Css NA 9.432 mg/L 3compartmentss NA 95% Human Human +DTXSID7040734 Css NA 0.8346 mg/L PBTK NA 50% Human Human +DTXSID7040734 Css NA 5.948 mg/L PBTK NA 95% Human Human +DTXSID7040734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040734 Fup 0.0306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040734 Vd NA 1.812 L/kg 1compartment NA NA Rat Human +DTXSID7040734 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7040734 TK.Half.Life NA 5.879 hours 1compartment NA NA Rat Human +DTXSID7040734 Css NA 0.1624 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040734 Css NA 0.9794 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040734 Css NA 0.1054 mg/L PBTK NA 50% Rat Human +DTXSID7040734 Css NA 0.6017 mg/L PBTK NA 95% Rat Human +DTXSID7040736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040736 Fup 0.0437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040736 Vd NA 1.774 L/kg 1compartment NA NA Human Human DTXSID7040736 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040736 TK.Half.Life NA 1.232 hours 1compartment NA NA Human Human -DTXSID7040736 Css NA 0.1331 mg/L 3compartmentss NA 50% Human Human -DTXSID7040736 Css NA 1.076 mg/L 3compartmentss NA 95% Human Human -DTXSID7040736 Css NA 0.08286 mg/L PBTK NA 50% Human Human -DTXSID7040736 Css NA 0.656 mg/L PBTK NA 95% Human Human -DTXSID7040736 Clint NA 152.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040736 Fup NA 0.0342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040736 Vd NA 0.5969 L/kg 1compartment NA NA Rat Human +DTXSID7040736 TK.Half.Life NA 9.752 hours 1compartment NA NA Human Human +DTXSID7040736 Css NA 0.729 mg/L 3compartmentss NA 50% Human Human +DTXSID7040736 Css NA 5.799 mg/L 3compartmentss NA 95% Human Human +DTXSID7040736 Css NA 0.4853 mg/L PBTK NA 50% Human Human +DTXSID7040736 Css NA 3.657 mg/L PBTK NA 95% Human Human +DTXSID7040736 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040736 Fup 0.0437 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040736 Vd NA 1.338 L/kg 1compartment NA NA Rat Human DTXSID7040736 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040736 TK.Half.Life NA 0.5089 hours 1compartment NA NA Rat Human -DTXSID7040736 Css NA 0.07616 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040736 Css NA 0.5087 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040736 Css NA 0.04448 mg/L PBTK NA 50% Rat Human -DTXSID7040736 Css NA 0.2876 mg/L PBTK NA 95% Rat Human -DTXSID7040738 Clint NA 10.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040738 Fup NA 0.0699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040738 Vd NA 3.18 L/kg 1compartment NA NA Human Human -DTXSID7040738 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7040738 TK.Half.Life NA 31.54 hours 1compartment NA NA Human Human -DTXSID7040738 Css NA 1.141 mg/L 3compartmentss NA 50% Human Human -DTXSID7040738 Css NA 7.25 mg/L 3compartmentss NA 95% Human Human -DTXSID7040738 Css NA 0.8256 mg/L PBTK NA 50% Human Human -DTXSID7040738 Css NA 5.09 mg/L PBTK NA 95% Human Human -DTXSID7040738 Clint NA 10.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040738 Fup NA 0.0699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040738 Vd NA 2.475 L/kg 1compartment NA NA Rat Human -DTXSID7040738 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7040738 TK.Half.Life NA 5.894 hours 1compartment NA NA Rat Human -DTXSID7040738 Css NA 0.637 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040738 Css NA 3.158 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040738 Css NA 0.443 mg/L PBTK NA 50% Rat Human -DTXSID7040738 Css NA 2.154 mg/L PBTK NA 95% Rat Human -DTXSID7040784 Clint NA 29.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040784 Fup NA 0.0141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040784 Vd NA 1511 L/kg 1compartment NA NA Human Human -DTXSID7040784 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID7040784 TK.Half.Life NA 33090 hours 1compartment NA NA Human Human -DTXSID7040784 Css NA 0.007232 mg/L 3compartmentss NA 50% Human Human -DTXSID7040784 Css NA 0.04664 mg/L 3compartmentss NA 95% Human Human -DTXSID7040784 Css NA 1.8 mg/L PBTK NA 50% Human Human -DTXSID7040784 Css NA 10.23 mg/L PBTK NA 95% Human Human -DTXSID7040784 Clint NA 29.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040784 Fup NA 0.0141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040784 Vd NA 1393 L/kg 1compartment NA NA Rat Human -DTXSID7040784 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID7040784 TK.Half.Life NA 5259 hours 1compartment NA NA Rat Human -DTXSID7040784 Css NA 0.00366 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040784 Css NA 0.01623 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040784 Css NA 0.9866 mg/L PBTK NA 50% Rat Human -DTXSID7040784 Css NA 4.282 mg/L PBTK NA 95% Rat Human +DTXSID7040736 TK.Half.Life NA 3.494 hours 1compartment NA NA Rat Human +DTXSID7040736 Css NA 0.09367 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040736 Css NA 0.6087 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040736 Css NA 0.06123 mg/L PBTK NA 50% Rat Human +DTXSID7040736 Css NA 0.3776 mg/L PBTK NA 95% Rat Human +DTXSID7040738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040738 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040738 Vd NA 3.466 L/kg 1compartment NA NA Human Human +DTXSID7040738 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7040738 TK.Half.Life NA 6.756 hours 1compartment NA NA Human Human +DTXSID7040738 Css NA 0.1282 mg/L 3compartmentss NA 50% Human Human +DTXSID7040738 Css NA 0.9187 mg/L 3compartmentss NA 95% Human Human +DTXSID7040738 Css NA 0.1144 mg/L PBTK NA 50% Human Human +DTXSID7040738 Css NA 0.7449 mg/L PBTK NA 95% Human Human +DTXSID7040738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040738 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040738 Vd NA 3.011 L/kg 1compartment NA NA Rat Human +DTXSID7040738 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7040738 TK.Half.Life NA 2.289 hours 1compartment NA NA Rat Human +DTXSID7040738 Css NA 0.0161 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040738 Css NA 0.08329 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040738 Css NA 0.01463 mg/L PBTK NA 50% Rat Human +DTXSID7040738 Css NA 0.0689 mg/L PBTK NA 95% Rat Human DTXSID7040788 Clint 7.06 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7040788 Fup 0.07217 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID7040788 Vd NA 1.959 L/kg 1compartment NA NA Human Human +DTXSID7040788 Vd NA 2.128 L/kg 1compartment NA NA Human Human DTXSID7040788 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7040788 TK.Half.Life NA 20.57 hours 1compartment NA NA Human Human -DTXSID7040788 Css NA 1.492 mg/L 3compartmentss NA 50% Human Human -DTXSID7040788 Css NA 9.38 mg/L 3compartmentss NA 95% Human Human -DTXSID7040788 Css NA 0.994 mg/L PBTK NA 50% Human Human -DTXSID7040788 Css NA 5.85 mg/L PBTK NA 95% Human Human +DTXSID7040788 TK.Half.Life NA 24.35 hours 1compartment NA NA Human Human +DTXSID7040788 Css NA 1.551 mg/L 3compartmentss NA 50% Human Human +DTXSID7040788 Css NA 9.245 mg/L 3compartmentss NA 95% Human Human +DTXSID7040788 Css NA 1.036 mg/L PBTK NA 50% Human Human +DTXSID7040788 Css NA 5.937 mg/L PBTK NA 95% Human Human DTXSID7040788 Clint 7.06 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7040788 Fup 0.07217 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID7040788 Vd NA 1.476 L/kg 1compartment NA NA Rat Human +DTXSID7040788 Vd NA 1.601 L/kg 1compartment NA NA Rat Human DTXSID7040788 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7040788 TK.Half.Life NA 6.646 hours 1compartment NA NA Rat Human -DTXSID7040788 Css NA 0.7925 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040788 Css NA 3.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040788 Css NA 0.4986 mg/L PBTK NA 50% Rat Human -DTXSID7040788 Css NA 2.031 mg/L PBTK NA 95% Rat Human -DTXSID7040948 Clint NA 0.4768 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040948 Fup NA 0.078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040948 Vd NA 0.2987 L/kg 1compartment NA NA Human Human -DTXSID7040948 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7040948 TK.Half.Life NA 13.9 hours 1compartment NA NA Human Human -DTXSID7040948 Css NA 7.322 mg/L 3compartmentss NA 50% Human Human -DTXSID7040948 Css NA 34.84 mg/L 3compartmentss NA 95% Human Human -DTXSID7040948 Css NA 4.558 mg/L PBTK NA 50% Human Human -DTXSID7040948 Css NA 20.74 mg/L PBTK NA 95% Human Human -DTXSID7040948 Clint NA 0.4768 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040948 Fup NA 0.078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040948 Vd NA 0.2927 L/kg 1compartment NA NA Rat Human +DTXSID7040788 TK.Half.Life NA 7.282 hours 1compartment NA NA Rat Human +DTXSID7040788 Css NA 0.1929 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040788 Css NA 0.8422 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040788 Css NA 0.1269 mg/L PBTK NA 50% Rat Human +DTXSID7040788 Css NA 0.5296 mg/L PBTK NA 95% Rat Human +DTXSID7040948 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040948 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040948 Vd NA 0.4642 L/kg 1compartment NA NA Human Human +DTXSID7040948 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7040948 TK.Half.Life NA 0.8246 hours 1compartment NA NA Human Human +DTXSID7040948 Css NA 0.1229 mg/L 3compartmentss NA 50% Human Human +DTXSID7040948 Css NA 0.8593 mg/L 3compartmentss NA 95% Human Human +DTXSID7040948 Css NA 0.08548 mg/L PBTK NA 50% Human Human +DTXSID7040948 Css NA 0.5698 mg/L PBTK NA 95% Human Human +DTXSID7040948 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040948 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040948 Vd NA 0.4554 L/kg 1compartment NA NA Rat Human DTXSID7040948 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040948 TK.Half.Life NA 5.991 hours 1compartment NA NA Rat Human -DTXSID7040948 Css NA 2.713 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040948 Css NA 11.14 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040948 Css NA 1.578 mg/L PBTK NA 50% Rat Human -DTXSID7040948 Css NA 6.12 mg/L PBTK NA 95% Rat Human -DTXSID7040990 Clint NA 12.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040990 Fup NA 0.0296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7040990 Vd NA 0.368 L/kg 1compartment NA NA Human Human +DTXSID7040948 TK.Half.Life NA 0.4587 hours 1compartment NA NA Rat Human +DTXSID7040948 Css NA 0.01554 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040948 Css NA 0.08406 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040948 Css NA 0.01067 mg/L PBTK NA 50% Rat Human +DTXSID7040948 Css NA 0.05436 mg/L PBTK NA 95% Rat Human +DTXSID7040990 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040990 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7040990 Vd NA 0.8591 L/kg 1compartment NA NA Human Human DTXSID7040990 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7040990 TK.Half.Life NA 4.011 hours 1compartment NA NA Human Human -DTXSID7040990 Css NA 1.878 mg/L 3compartmentss NA 50% Human Human -DTXSID7040990 Css NA 16.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7040990 Css NA 1.136 mg/L PBTK NA 50% Human Human -DTXSID7040990 Css NA 9.807 mg/L PBTK NA 95% Human Human -DTXSID7040990 Clint NA 12.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040990 Fup NA 0.0296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7040990 Vd NA 0.3094 L/kg 1compartment NA NA Rat Human +DTXSID7040990 TK.Half.Life NA 3.59 hours 1compartment NA NA Human Human +DTXSID7040990 Css NA 0.4528 mg/L 3compartmentss NA 50% Human Human +DTXSID7040990 Css NA 2.72 mg/L 3compartmentss NA 95% Human Human +DTXSID7040990 Css NA 0.3173 mg/L PBTK NA 50% Human Human +DTXSID7040990 Css NA 1.764 mg/L PBTK NA 95% Human Human +DTXSID7040990 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040990 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7040990 Vd NA 0.7129 L/kg 1compartment NA NA Rat Human DTXSID7040990 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7040990 TK.Half.Life NA 2.163 hours 1compartment NA NA Rat Human -DTXSID7040990 Css NA 1.049 mg/L 3compartmentss NA 50% Rat Human -DTXSID7040990 Css NA 7.684 mg/L 3compartmentss NA 95% Rat Human -DTXSID7040990 Css NA 0.5871 mg/L PBTK NA 50% Rat Human -DTXSID7040990 Css NA 4.184 mg/L PBTK NA 95% Rat Human +DTXSID7040990 TK.Half.Life NA 1.693 hours 1compartment NA NA Rat Human +DTXSID7040990 Css NA 0.05414 mg/L 3compartmentss NA 50% Rat Human +DTXSID7040990 Css NA 0.2416 mg/L 3compartmentss NA 95% Rat Human +DTXSID7040990 Css NA 0.03744 mg/L PBTK NA 50% Rat Human +DTXSID7040990 Css NA 0.1524 mg/L PBTK NA 95% Rat Human DTXSID7041045 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7041045 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041045 Vd NA 0.8404 L/kg 1compartment NA NA Human Human +DTXSID7041045 Vd NA 1.048 L/kg 1compartment NA NA Human Human DTXSID7041045 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041045 TK.Half.Life NA 5.441 hours 1compartment NA NA Human Human -DTXSID7041045 Css NA 0.8042 mg/L 3compartmentss NA 50% Human Human -DTXSID7041045 Css NA 5.496 mg/L 3compartmentss NA 95% Human Human -DTXSID7041045 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID7041045 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID7041045 TK.Half.Life NA 6.782 hours 1compartment NA NA Human Human +DTXSID7041045 Css NA 0.6596 mg/L 3compartmentss NA 50% Human Human +DTXSID7041045 Css NA 4.869 mg/L 3compartmentss NA 95% Human Human +DTXSID7041045 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID7041045 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID7041045 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7041045 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041045 Vd NA 0.8859 L/kg 1compartment NA NA Rat Human +DTXSID7041045 Vd NA 1.115 L/kg 1compartment NA NA Rat Human DTXSID7041045 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041045 TK.Half.Life NA 1.953 hours 1compartment NA NA Rat Human -DTXSID7041045 Css NA 0.2011 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041045 Css NA 1.316 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041045 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID7041045 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID7041047 Clint NA 11.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041047 Fup NA 0.0936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041047 Vd NA 1.756 L/kg 1compartment NA NA Human Human +DTXSID7041045 TK.Half.Life NA 2.458 hours 1compartment NA NA Rat Human +DTXSID7041045 Css NA 0.012 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041045 Css NA 0.09634 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041045 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID7041045 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID7041047 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041047 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041047 Vd NA 2.235 L/kg 1compartment NA NA Human Human DTXSID7041047 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041047 TK.Half.Life NA 8.175 hours 1compartment NA NA Human Human -DTXSID7041047 Css NA 0.5814 mg/L 3compartmentss NA 50% Human Human -DTXSID7041047 Css NA 4.416 mg/L 3compartmentss NA 95% Human Human -DTXSID7041047 Css NA 0.4056 mg/L PBTK NA 50% Human Human -DTXSID7041047 Css NA 2.797 mg/L PBTK NA 95% Human Human -DTXSID7041047 Clint NA 11.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041047 Fup NA 0.0936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041047 Vd NA 1.461 L/kg 1compartment NA NA Rat Human +DTXSID7041047 TK.Half.Life NA 5.599 hours 1compartment NA NA Human Human +DTXSID7041047 Css NA 0.2346 mg/L 3compartmentss NA 50% Human Human +DTXSID7041047 Css NA 1.799 mg/L 3compartmentss NA 95% Human Human +DTXSID7041047 Css NA 0.172 mg/L PBTK NA 50% Human Human +DTXSID7041047 Css NA 1.236 mg/L PBTK NA 95% Human Human +DTXSID7041047 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041047 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041047 Vd NA 1.845 L/kg 1compartment NA NA Rat Human DTXSID7041047 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041047 TK.Half.Life NA 3.567 hours 1compartment NA NA Rat Human -DTXSID7041047 Css NA 0.3191 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041047 Css NA 1.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041047 Css NA 0.2106 mg/L PBTK NA 50% Rat Human -DTXSID7041047 Css NA 1.053 mg/L PBTK NA 95% Rat Human -DTXSID7041091 Clint NA 0.7919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041091 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041091 Vd NA 0.5693 L/kg 1compartment NA NA Human Human +DTXSID7041047 TK.Half.Life NA 2.156 hours 1compartment NA NA Rat Human +DTXSID7041047 Css NA 0.02946 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041047 Css NA 0.1795 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041047 Css NA 0.02146 mg/L PBTK NA 50% Rat Human +DTXSID7041047 Css NA 0.12 mg/L PBTK NA 95% Rat Human +DTXSID7041091 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041091 Fup 0.679 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041091 Vd NA 0.4608 L/kg 1compartment NA NA Human Human DTXSID7041091 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041091 TK.Half.Life NA 1.707 hours 1compartment NA NA Human Human -DTXSID7041091 Css NA 0.3904 mg/L 3compartmentss NA 50% Human Human -DTXSID7041091 Css NA 2.422 mg/L 3compartmentss NA 95% Human Human -DTXSID7041091 Css NA 0.3013 mg/L PBTK NA 50% Human Human -DTXSID7041091 Css NA 1.596 mg/L PBTK NA 95% Human Human -DTXSID7041091 Clint NA 0.7919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041091 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041091 Vd NA 0.5866 L/kg 1compartment NA NA Rat Human +DTXSID7041091 TK.Half.Life NA 4.39 hours 1compartment NA NA Human Human +DTXSID7041091 Css NA 1.187 mg/L 3compartmentss NA 50% Human Human +DTXSID7041091 Css NA 7.23 mg/L 3compartmentss NA 95% Human Human +DTXSID7041091 Css NA 0.8735 mg/L PBTK NA 50% Human Human +DTXSID7041091 Css NA 4.466 mg/L PBTK NA 95% Human Human +DTXSID7041091 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041091 Fup 0.679 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041091 Vd NA 0.4736 L/kg 1compartment NA NA Rat Human DTXSID7041091 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041091 TK.Half.Life NA 0.814 hours 1compartment NA NA Rat Human -DTXSID7041091 Css NA 0.1416 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041091 Css NA 0.8372 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041091 Css NA 0.1065 mg/L PBTK NA 50% Rat Human -DTXSID7041091 Css NA 0.4876 mg/L PBTK NA 95% Rat Human +DTXSID7041091 TK.Half.Life NA 1.538 hours 1compartment NA NA Rat Human +DTXSID7041091 Css NA 0.07269 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041091 Css NA 0.4163 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041091 Css NA 0.05292 mg/L PBTK NA 50% Rat Human +DTXSID7041091 Css NA 0.2478 mg/L PBTK NA 95% Rat Human DTXSID7041097 Clint 42.12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7041097 Fup 0.01614 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID7041097 Vd NA 2.877 L/kg 1compartment NA NA Human Human +DTXSID7041097 Vd NA 2.884 L/kg 1compartment NA NA Human Human DTXSID7041097 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7041097 TK.Half.Life NA 28.27 hours 1compartment NA NA Human Human -DTXSID7041097 Css NA 1.258 mg/L 3compartmentss NA 50% Human Human -DTXSID7041097 Css NA 8.335 mg/L 3compartmentss NA 95% Human Human -DTXSID7041097 Css NA 0.8519 mg/L PBTK NA 50% Human Human -DTXSID7041097 Css NA 5.471 mg/L PBTK NA 95% Human Human +DTXSID7041097 TK.Half.Life NA 28.47 hours 1compartment NA NA Human Human +DTXSID7041097 Css NA 1.228 mg/L 3compartmentss NA 50% Human Human +DTXSID7041097 Css NA 8.756 mg/L 3compartmentss NA 95% Human Human +DTXSID7041097 Css NA 0.8273 mg/L PBTK NA 50% Human Human +DTXSID7041097 Css NA 5.685 mg/L PBTK NA 95% Human Human DTXSID7041097 Clint 42.12 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7041097 Fup 0.01614 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID7041097 Vd NA 2.153 L/kg 1compartment NA NA Rat Human +DTXSID7041097 Vd NA 2.159 L/kg 1compartment NA NA Rat Human DTXSID7041097 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7041097 TK.Half.Life NA 5.344 hours 1compartment NA NA Rat Human -DTXSID7041097 Css NA 0.7016 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041097 Css NA 3.993 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041097 Css NA 0.454 mg/L PBTK NA 50% Rat Human -DTXSID7041097 Css NA 2.5 mg/L PBTK NA 95% Rat Human -DTXSID7041126 Clint NA 0.008307 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041126 Fup NA 0.0676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041126 Vd NA 3.11 L/kg 1compartment NA NA Human Human -DTXSID7041126 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID7041126 TK.Half.Life NA 17600 hours 1compartment NA NA Human Human -DTXSID7041126 Css NA 634.1 mg/L 3compartmentss NA 50% Human Human -DTXSID7041126 Css NA 1756 mg/L 3compartmentss NA 95% Human Human -DTXSID7041126 Css NA 442.8 mg/L PBTK NA 50% Human Human -DTXSID7041126 Css NA 1141 mg/L PBTK NA 95% Human Human -DTXSID7041126 Clint NA 0.008307 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041126 Fup NA 0.0676 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041126 Vd NA 2.331 L/kg 1compartment NA NA Rat Human -DTXSID7041126 Days.Css NA 1305 Days PBTK NA NA Rat Human -DTXSID7041126 TK.Half.Life NA 1186 hours 1compartment NA NA Rat Human -DTXSID7041126 Css NA 184.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041126 Css NA 396.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041126 Css NA 123.3 mg/L PBTK NA 50% Rat Human -DTXSID7041126 Css NA 239.4 mg/L PBTK NA 95% Rat Human +DTXSID7041097 TK.Half.Life NA 5.361 hours 1compartment NA NA Rat Human +DTXSID7041097 Css NA 0.1578 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041097 Css NA 0.9517 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041097 Css NA 0.1056 mg/L PBTK NA 50% Rat Human +DTXSID7041097 Css NA 0.6088 mg/L PBTK NA 95% Rat Human DTXSID7041178 Clint NA 0.1131 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7041178 Fup NA 0.1211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041178 Vd NA 0.3683 L/kg 1compartment NA NA Human Human -DTXSID7041178 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7041178 TK.Half.Life NA 16.57 hours 1compartment NA NA Human Human -DTXSID7041178 Css NA 6.516 mg/L 3compartmentss NA 50% Human Human -DTXSID7041178 Css NA 31.69 mg/L 3compartmentss NA 95% Human Human -DTXSID7041178 Css NA 4.185 mg/L PBTK NA 50% Human Human -DTXSID7041178 Css NA 18.73 mg/L PBTK NA 95% Human Human +DTXSID7041178 Vd NA 0.2487 L/kg 1compartment NA NA Human Human +DTXSID7041178 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7041178 TK.Half.Life NA 3.096 hours 1compartment NA NA Human Human +DTXSID7041178 Css NA 1.644 mg/L 3compartmentss NA 50% Human Human +DTXSID7041178 Css NA 9.225 mg/L 3compartmentss NA 95% Human Human +DTXSID7041178 Css NA 1.004 mg/L PBTK NA 50% Human Human +DTXSID7041178 Css NA 5.525 mg/L PBTK NA 95% Human Human DTXSID7041178 Clint NA 0.1131 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7041178 Fup NA 0.1211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041178 Vd NA 0.367 L/kg 1compartment NA NA Rat Human +DTXSID7041178 Vd NA 0.2599 L/kg 1compartment NA NA Rat Human DTXSID7041178 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041178 TK.Half.Life NA 6.123 hours 1compartment NA NA Rat Human -DTXSID7041178 Css NA 2.038 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041178 Css NA 8.326 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041178 Css NA 1.221 mg/L PBTK NA 50% Rat Human -DTXSID7041178 Css NA 4.628 mg/L PBTK NA 95% Rat Human -DTXSID7041209 Clint NA 2.217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041209 Fup NA 0.3073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041209 Vd NA 2.652 L/kg 1compartment NA NA Human Human -DTXSID7041209 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7041209 TK.Half.Life NA 35.08 hours 1compartment NA NA Human Human -DTXSID7041209 Css NA 1.465 mg/L 3compartmentss NA 50% Human Human -DTXSID7041209 Css NA 6.025 mg/L 3compartmentss NA 95% Human Human -DTXSID7041209 Css NA 1.102 mg/L PBTK NA 50% Human Human -DTXSID7041209 Css NA 4.238 mg/L PBTK NA 95% Human Human -DTXSID7041209 Clint NA 2.217 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041209 Fup NA 0.3073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041209 Vd NA 2.03 L/kg 1compartment NA NA Rat Human -DTXSID7041209 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7041209 TK.Half.Life NA 7.333 hours 1compartment NA NA Rat Human -DTXSID7041209 Css NA 0.6889 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041209 Css NA 2.008 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041209 Css NA 0.4962 mg/L PBTK NA 50% Rat Human -DTXSID7041209 Css NA 1.327 mg/L PBTK NA 95% Rat Human -DTXSID7041253 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041253 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041253 Vd NA 0.8177 L/kg 1compartment NA NA Human Human +DTXSID7041178 TK.Half.Life NA 1.798 hours 1compartment NA NA Rat Human +DTXSID7041178 Css NA 0.05029 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041178 Css NA 0.3568 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041178 Css NA 0.02925 mg/L PBTK NA 50% Rat Human +DTXSID7041178 Css NA 0.2027 mg/L PBTK NA 95% Rat Human +DTXSID7041201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041201 Fup 0.00389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041201 Vd NA 7.937 L/kg 1compartment NA NA Human Human +DTXSID7041201 Days.Css NA 48 Days PBTK NA NA Human Human +DTXSID7041201 TK.Half.Life NA 243.9 hours 1compartment NA NA Human Human +DTXSID7041201 Css NA 2.411 mg/L 3compartmentss NA 50% Human Human +DTXSID7041201 Css NA 14.26 mg/L 3compartmentss NA 95% Human Human +DTXSID7041201 Css NA 2.45 mg/L PBTK NA 50% Human Human +DTXSID7041201 Css NA 14.19 mg/L PBTK NA 95% Human Human +DTXSID7041201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041201 Fup 0.00389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041201 Vd NA 6.185 L/kg 1compartment NA NA Rat Human +DTXSID7041201 Days.Css NA 29 Days PBTK NA NA Rat Human +DTXSID7041201 TK.Half.Life NA 36.06 hours 1compartment NA NA Rat Human +DTXSID7041201 Css NA 0.3064 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041201 Css NA 1.525 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041201 Css NA 0.3188 mg/L PBTK NA 50% Rat Human +DTXSID7041201 Css NA 1.634 mg/L PBTK NA 95% Rat Human +DTXSID7041209 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041209 Fup 0.235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041209 Vd NA 2.406 L/kg 1compartment NA NA Human Human +DTXSID7041209 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7041209 TK.Half.Life NA 5.382 hours 1compartment NA NA Human Human +DTXSID7041209 Css NA 0.1742 mg/L 3compartmentss NA 50% Human Human +DTXSID7041209 Css NA 1.153 mg/L 3compartmentss NA 95% Human Human +DTXSID7041209 Css NA 0.1279 mg/L PBTK NA 50% Human Human +DTXSID7041209 Css NA 0.8069 mg/L PBTK NA 95% Human Human +DTXSID7041209 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041209 Fup 0.235 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041209 Vd NA 1.844 L/kg 1compartment NA NA Rat Human +DTXSID7041209 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7041209 TK.Half.Life NA 1.584 hours 1compartment NA NA Rat Human +DTXSID7041209 Css NA 0.02206 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041209 Css NA 0.1105 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041209 Css NA 0.01616 mg/L PBTK NA 50% Rat Human +DTXSID7041209 Css NA 0.07764 mg/L PBTK NA 95% Rat Human +DTXSID7041253 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041253 Fup 0.776 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041253 Vd NA 0.7044 L/kg 1compartment NA NA Human Human DTXSID7041253 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041253 TK.Half.Life NA 5.295 hours 1compartment NA NA Human Human -DTXSID7041253 Css NA 0.8198 mg/L 3compartmentss NA 50% Human Human -DTXSID7041253 Css NA 5.481 mg/L 3compartmentss NA 95% Human Human -DTXSID7041253 Css NA 0.7004 mg/L PBTK NA 50% Human Human -DTXSID7041253 Css NA 3.55 mg/L PBTK NA 95% Human Human -DTXSID7041253 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041253 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041253 Vd NA 0.8501 L/kg 1compartment NA NA Rat Human +DTXSID7041253 TK.Half.Life NA 5.879 hours 1compartment NA NA Human Human +DTXSID7041253 Css NA 0.9935 mg/L 3compartmentss NA 50% Human Human +DTXSID7041253 Css NA 6.338 mg/L 3compartmentss NA 95% Human Human +DTXSID7041253 Css NA 0.8086 mg/L PBTK NA 50% Human Human +DTXSID7041253 Css NA 4.073 mg/L PBTK NA 95% Human Human +DTXSID7041253 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041253 Fup 0.776 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041253 Vd NA 0.7309 L/kg 1compartment NA NA Rat Human DTXSID7041253 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041253 TK.Half.Life NA 1.875 hours 1compartment NA NA Rat Human -DTXSID7041253 Css NA 0.2054 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041253 Css NA 1.312 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041253 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID7041253 Css NA 0.7933 mg/L PBTK NA 95% Rat Human -DTXSID7041336 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041336 Fup NA 0.0129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041336 Vd NA 0.9856 L/kg 1compartment NA NA Human Human -DTXSID7041336 Days.Css NA 148 Days PBTK NA NA Human Human -DTXSID7041336 TK.Half.Life NA 582.5 hours 1compartment NA NA Human Human -DTXSID7041336 Css NA 96.76 mg/L 3compartmentss NA 50% Human Human -DTXSID7041336 Css NA 561 mg/L 3compartmentss NA 95% Human Human -DTXSID7041336 Css NA 58.58 mg/L PBTK NA 50% Human Human -DTXSID7041336 Css NA 324.7 mg/L PBTK NA 95% Human Human -DTXSID7041336 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041336 Fup NA 0.0129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041336 Vd NA 0.728 L/kg 1compartment NA NA Rat Human -DTXSID7041336 Days.Css NA 33 Days PBTK NA NA Rat Human -DTXSID7041336 TK.Half.Life NA 129.8 hours 1compartment NA NA Rat Human -DTXSID7041336 Css NA 27.54 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041336 Css NA 135.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041336 Css NA 15.56 mg/L PBTK NA 50% Rat Human -DTXSID7041336 Css NA 74.08 mg/L PBTK NA 95% Rat Human -DTXSID7041388 Clint NA 1.526 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041388 Fup NA 0.7398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041388 Vd NA 1.063 L/kg 1compartment NA NA Human Human -DTXSID7041388 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041388 TK.Half.Life NA 3.033 hours 1compartment NA NA Human Human -DTXSID7041388 Css NA 0.2946 mg/L 3compartmentss NA 50% Human Human -DTXSID7041388 Css NA 2.007 mg/L 3compartmentss NA 95% Human Human -DTXSID7041388 Css NA 0.253 mg/L PBTK NA 50% Human Human -DTXSID7041388 Css NA 1.354 mg/L PBTK NA 95% Human Human -DTXSID7041388 Clint NA 1.526 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041388 Fup NA 0.7398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041388 Vd NA 1.01 L/kg 1compartment NA NA Rat Human +DTXSID7041253 TK.Half.Life NA 2.077 hours 1compartment NA NA Rat Human +DTXSID7041253 Css NA 0.05835 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041253 Css NA 0.3624 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041253 Css NA 0.04774 mg/L PBTK NA 50% Rat Human +DTXSID7041253 Css NA 0.2229 mg/L PBTK NA 95% Rat Human +DTXSID7041336 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041336 Fup 0.0132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041336 Vd NA 1.099 L/kg 1compartment NA NA Human Human +DTXSID7041336 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7041336 TK.Half.Life NA 13.43 hours 1compartment NA NA Human Human +DTXSID7041336 Css NA 2.039 mg/L 3compartmentss NA 50% Human Human +DTXSID7041336 Css NA 19.27 mg/L 3compartmentss NA 95% Human Human +DTXSID7041336 Css NA 1.244 mg/L PBTK NA 50% Human Human +DTXSID7041336 Css NA 11.55 mg/L PBTK NA 95% Human Human +DTXSID7041336 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041336 Fup 0.0132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041336 Vd NA 0.8111 L/kg 1compartment NA NA Rat Human +DTXSID7041336 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7041336 TK.Half.Life NA 5.743 hours 1compartment NA NA Rat Human +DTXSID7041336 Css NA 0.2663 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041336 Css NA 2.055 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041336 Css NA 0.1567 mg/L PBTK NA 50% Rat Human +DTXSID7041336 Css NA 1.167 mg/L PBTK NA 95% Rat Human +DTXSID7041388 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041388 Fup 0.601 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041388 Vd NA 0.9616 L/kg 1compartment NA NA Human Human +DTXSID7041388 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7041388 TK.Half.Life NA 10.71 hours 1compartment NA NA Human Human +DTXSID7041388 Css NA 1.176 mg/L 3compartmentss NA 50% Human Human +DTXSID7041388 Css NA 8.093 mg/L 3compartmentss NA 95% Human Human +DTXSID7041388 Css NA 0.9799 mg/L PBTK NA 50% Human Human +DTXSID7041388 Css NA 5.254 mg/L PBTK NA 95% Human Human +DTXSID7041388 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041388 Fup 0.601 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041388 Vd NA 0.9075 L/kg 1compartment NA NA Rat Human DTXSID7041388 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041388 TK.Half.Life NA 1.434 hours 1compartment NA NA Rat Human -DTXSID7041388 Css NA 0.1179 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041388 Css NA 0.7722 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041388 Css NA 0.1006 mg/L PBTK NA 50% Rat Human -DTXSID7041388 Css NA 0.4768 mg/L PBTK NA 95% Rat Human -DTXSID7041411 Clint NA 5.332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041411 Fup NA 0.0991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041411 Vd NA 0.9218 L/kg 1compartment NA NA Human Human +DTXSID7041388 TK.Half.Life NA 3.357 hours 1compartment NA NA Rat Human +DTXSID7041388 Css NA 0.07084 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041388 Css NA 0.4916 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041388 Css NA 0.05928 mg/L PBTK NA 50% Rat Human +DTXSID7041388 Css NA 0.3018 mg/L PBTK NA 95% Rat Human +DTXSID7041411 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041411 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041411 Vd NA 1.219 L/kg 1compartment NA NA Human Human DTXSID7041411 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041411 TK.Half.Life NA 6.943 hours 1compartment NA NA Human Human -DTXSID7041411 Css NA 1.105 mg/L 3compartmentss NA 50% Human Human -DTXSID7041411 Css NA 7.389 mg/L 3compartmentss NA 95% Human Human -DTXSID7041411 Css NA 0.7097 mg/L PBTK NA 50% Human Human -DTXSID7041411 Css NA 4.498 mg/L PBTK NA 95% Human Human -DTXSID7041411 Clint NA 5.332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041411 Fup NA 0.0991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041411 Vd NA 0.7313 L/kg 1compartment NA NA Rat Human +DTXSID7041411 TK.Half.Life NA 2.938 hours 1compartment NA NA Human Human +DTXSID7041411 Css NA 0.242 mg/L 3compartmentss NA 50% Human Human +DTXSID7041411 Css NA 1.905 mg/L 3compartmentss NA 95% Human Human +DTXSID7041411 Css NA 0.1602 mg/L PBTK NA 50% Human Human +DTXSID7041411 Css NA 1.216 mg/L PBTK NA 95% Human Human +DTXSID7041411 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041411 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041411 Vd NA 0.9515 L/kg 1compartment NA NA Rat Human DTXSID7041411 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041411 TK.Half.Life NA 3.121 hours 1compartment NA NA Rat Human -DTXSID7041411 Css NA 0.5763 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041411 Css NA 2.742 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041411 Css NA 0.3498 mg/L PBTK NA 50% Rat Human -DTXSID7041411 Css NA 1.562 mg/L PBTK NA 95% Rat Human -DTXSID7041417 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041417 Fup NA 0.9267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041417 Vd NA 0.7357 L/kg 1compartment NA NA Human Human +DTXSID7041411 TK.Half.Life NA 1.221 hours 1compartment NA NA Rat Human +DTXSID7041411 Css NA 0.03114 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041411 Css NA 0.193 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041411 Css NA 0.02023 mg/L PBTK NA 50% Rat Human +DTXSID7041411 Css NA 0.1165 mg/L PBTK NA 95% Rat Human +DTXSID7041413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041413 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041413 Vd NA 1.652 L/kg 1compartment NA NA Human Human +DTXSID7041413 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7041413 TK.Half.Life NA 2.679 hours 1compartment NA NA Human Human +DTXSID7041413 Css NA 0.1038 mg/L 3compartmentss NA 50% Human Human +DTXSID7041413 Css NA 0.7069 mg/L 3compartmentss NA 95% Human Human +DTXSID7041413 Css NA 0.07646 mg/L PBTK NA 50% Human Human +DTXSID7041413 Css NA 0.4828 mg/L PBTK NA 95% Human Human +DTXSID7041413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041413 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041413 Vd NA 1.304 L/kg 1compartment NA NA Rat Human +DTXSID7041413 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7041413 TK.Half.Life NA 1.016 hours 1compartment NA NA Rat Human +DTXSID7041413 Css NA 0.01303 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041413 Css NA 0.06826 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041413 Css NA 0.00959 mg/L PBTK NA 50% Rat Human +DTXSID7041413 Css NA 0.04826 mg/L PBTK NA 95% Rat Human +DTXSID7041417 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041417 Fup 0.83 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041417 Vd NA 0.7036 L/kg 1compartment NA NA Human Human DTXSID7041417 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041417 TK.Half.Life NA 5.138 hours 1compartment NA NA Human Human -DTXSID7041417 Css NA 0.8719 mg/L 3compartmentss NA 50% Human Human -DTXSID7041417 Css NA 3.219 mg/L 3compartmentss NA 95% Human Human -DTXSID7041417 Css NA 0.7251 mg/L PBTK NA 50% Human Human -DTXSID7041417 Css NA 2.25 mg/L PBTK NA 95% Human Human -DTXSID7041417 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041417 Fup NA 0.9267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041417 Vd NA 0.7702 L/kg 1compartment NA NA Rat Human +DTXSID7041417 TK.Half.Life NA 5.488 hours 1compartment NA NA Human Human +DTXSID7041417 Css NA 0.8286 mg/L 3compartmentss NA 50% Human Human +DTXSID7041417 Css NA 5.058 mg/L 3compartmentss NA 95% Human Human +DTXSID7041417 Css NA 0.6774 mg/L PBTK NA 50% Human Human +DTXSID7041417 Css NA 3.253 mg/L PBTK NA 95% Human Human +DTXSID7041417 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041417 Fup 0.83 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041417 Vd NA 0.7331 L/kg 1compartment NA NA Rat Human DTXSID7041417 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041417 TK.Half.Life NA 1.833 hours 1compartment NA NA Rat Human -DTXSID7041417 Css NA 0.226 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041417 Css NA 0.7879 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041417 Css NA 0.1825 mg/L PBTK NA 50% Rat Human -DTXSID7041417 Css NA 0.502 mg/L PBTK NA 95% Rat Human +DTXSID7041417 TK.Half.Life NA 1.948 hours 1compartment NA NA Rat Human +DTXSID7041417 Css NA 0.01557 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041417 Css NA 0.1153 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041417 Css NA 0.01223 mg/L PBTK NA 50% Rat Human +DTXSID7041417 Css NA 0.07487 mg/L PBTK NA 95% Rat Human DTXSID7041461 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7041461 Fup NA 0.2553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041461 Vd NA 2.364 L/kg 1compartment NA NA Human Human -DTXSID7041461 Days.Css NA 28 Days PBTK NA NA Human Human -DTXSID7041461 TK.Half.Life NA 142.6 hours 1compartment NA NA Human Human -DTXSID7041461 Css NA 6.673 mg/L 3compartmentss NA 50% Human Human -DTXSID7041461 Css NA 20.76 mg/L 3compartmentss NA 95% Human Human -DTXSID7041461 Css NA 4.976 mg/L PBTK NA 50% Human Human -DTXSID7041461 Css NA 13.75 mg/L PBTK NA 95% Human Human +DTXSID7041461 Vd NA 2.446 L/kg 1compartment NA NA Human Human +DTXSID7041461 Days.Css NA 32 Days PBTK NA NA Human Human +DTXSID7041461 TK.Half.Life NA 162.6 hours 1compartment NA NA Human Human +DTXSID7041461 Css NA 6.182 mg/L 3compartmentss NA 50% Human Human +DTXSID7041461 Css NA 19.54 mg/L 3compartmentss NA 95% Human Human +DTXSID7041461 Css NA 4.614 mg/L PBTK NA 50% Human Human +DTXSID7041461 Css NA 13.11 mg/L PBTK NA 95% Human Human DTXSID7041461 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7041461 Fup NA 0.2553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041461 Vd NA 1.818 L/kg 1compartment NA NA Rat Human -DTXSID7041461 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID7041461 TK.Half.Life NA 20.87 hours 1compartment NA NA Rat Human -DTXSID7041461 Css NA 1.803 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041461 Css NA 4.51 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041461 Css NA 1.291 mg/L PBTK NA 50% Rat Human -DTXSID7041461 Css NA 2.8 mg/L PBTK NA 95% Rat Human +DTXSID7041461 Vd NA 1.876 L/kg 1compartment NA NA Rat Human +DTXSID7041461 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID7041461 TK.Half.Life NA 22.47 hours 1compartment NA NA Rat Human +DTXSID7041461 Css NA 0.1096 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041461 Css NA 0.5556 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041461 Css NA 0.07872 mg/L PBTK NA 50% Rat Human +DTXSID7041461 Css NA 0.3728 mg/L PBTK NA 95% Rat Human DTXSID7041467 Clint NA 0.01752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7041467 Fup NA 0.0715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041467 Vd NA 0.3348 L/kg 1compartment NA NA Human Human +DTXSID7041467 Vd NA 0.3491 L/kg 1compartment NA NA Human Human DTXSID7041467 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7041467 TK.Half.Life NA 29.45 hours 1compartment NA NA Human Human -DTXSID7041467 Css NA 13.24 mg/L 3compartmentss NA 50% Human Human -DTXSID7041467 Css NA 56.78 mg/L 3compartmentss NA 95% Human Human -DTXSID7041467 Css NA 8.26 mg/L PBTK NA 50% Human Human -DTXSID7041467 Css NA 33.79 mg/L PBTK NA 95% Human Human +DTXSID7041467 TK.Half.Life NA 30.7 hours 1compartment NA NA Human Human +DTXSID7041467 Css NA 12.91 mg/L 3compartmentss NA 50% Human Human +DTXSID7041467 Css NA 53.05 mg/L 3compartmentss NA 95% Human Human +DTXSID7041467 Css NA 8.078 mg/L PBTK NA 50% Human Human +DTXSID7041467 Css NA 31.56 mg/L PBTK NA 95% Human Human DTXSID7041467 Clint NA 0.01752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7041467 Fup NA 0.0715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041467 Vd NA 0.3301 L/kg 1compartment NA NA Rat Human +DTXSID7041467 Vd NA 0.3436 L/kg 1compartment NA NA Rat Human DTXSID7041467 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7041467 TK.Half.Life NA 10.04 hours 1compartment NA NA Rat Human -DTXSID7041467 Css NA 3.879 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041467 Css NA 13.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041467 Css NA 2.263 mg/L PBTK NA 50% Rat Human -DTXSID7041467 Css NA 7.261 mg/L PBTK NA 95% Rat Human +DTXSID7041467 TK.Half.Life NA 10.45 hours 1compartment NA NA Rat Human +DTXSID7041467 Css NA 0.8673 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041467 Css NA 2.958 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041467 Css NA 0.5274 mg/L PBTK NA 50% Rat Human +DTXSID7041467 Css NA 1.699 mg/L PBTK NA 95% Rat Human DTXSID7041540 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7041540 Fup NA 0.1873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041540 Vd NA 0.4024 L/kg 1compartment NA NA Human Human +DTXSID7041540 Vd NA 0.4001 L/kg 1compartment NA NA Human Human DTXSID7041540 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7041540 TK.Half.Life NA 13.9 hours 1compartment NA NA Human Human -DTXSID7041540 Css NA 4.19 mg/L 3compartmentss NA 50% Human Human -DTXSID7041540 Css NA 15.38 mg/L 3compartmentss NA 95% Human Human -DTXSID7041540 Css NA 2.808 mg/L PBTK NA 50% Human Human -DTXSID7041540 Css NA 9.408 mg/L PBTK NA 95% Human Human +DTXSID7041540 TK.Half.Life NA 13.82 hours 1compartment NA NA Human Human +DTXSID7041540 Css NA 2.246 mg/L 3compartmentss NA 50% Human Human +DTXSID7041540 Css NA 9.033 mg/L 3compartmentss NA 95% Human Human +DTXSID7041540 Css NA 1.508 mg/L PBTK NA 50% Human Human +DTXSID7041540 Css NA 5.544 mg/L PBTK NA 95% Human Human DTXSID7041540 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7041540 Fup NA 0.1873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041540 Vd NA 0.4044 L/kg 1compartment NA NA Rat Human +DTXSID7041540 Vd NA 0.4022 L/kg 1compartment NA NA Rat Human DTXSID7041540 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041540 TK.Half.Life NA 4.761 hours 1compartment NA NA Rat Human -DTXSID7041540 Css NA 1.164 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041540 Css NA 3.522 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041540 Css NA 0.7365 mg/L PBTK NA 50% Rat Human -DTXSID7041540 Css NA 2.021 mg/L PBTK NA 95% Rat Human -DTXSID7041621 Clint NA 33.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041621 Fup NA 0.0799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041621 Vd NA 0.3659 L/kg 1compartment NA NA Human Human +DTXSID7041540 TK.Half.Life NA 4.735 hours 1compartment NA NA Rat Human +DTXSID7041540 Css NA 0.01212 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041540 Css NA 0.04854 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041540 Css NA 0.007694 mg/L PBTK NA 50% Rat Human +DTXSID7041540 Css NA 0.02856 mg/L PBTK NA 95% Rat Human +DTXSID7041544 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041544 Fup 0.0172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041544 Vd NA 3.106 L/kg 1compartment NA NA Human Human +DTXSID7041544 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID7041544 TK.Half.Life NA 87.34 hours 1compartment NA NA Human Human +DTXSID7041544 Css NA 3.351 mg/L 3compartmentss NA 50% Human Human +DTXSID7041544 Css NA 21.27 mg/L 3compartmentss NA 95% Human Human +DTXSID7041544 Css NA 2.317 mg/L PBTK NA 50% Human Human +DTXSID7041544 Css NA 14.42 mg/L PBTK NA 95% Human Human +DTXSID7041544 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041544 Fup 0.0172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041544 Vd NA 2.327 L/kg 1compartment NA NA Rat Human +DTXSID7041544 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID7041544 TK.Half.Life NA 11.98 hours 1compartment NA NA Rat Human +DTXSID7041544 Css NA 0.4348 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041544 Css NA 2.267 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041544 Css NA 0.2992 mg/L PBTK NA 50% Rat Human +DTXSID7041544 Css NA 1.502 mg/L PBTK NA 95% Rat Human +DTXSID7041621 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041621 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041621 Vd NA 0.4993 L/kg 1compartment NA NA Human Human DTXSID7041621 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041621 TK.Half.Life NA 0.8378 hours 1compartment NA NA Human Human -DTXSID7041621 Css NA 0.2475 mg/L 3compartmentss NA 50% Human Human -DTXSID7041621 Css NA 2.002 mg/L 3compartmentss NA 95% Human Human -DTXSID7041621 Css NA 0.1551 mg/L PBTK NA 50% Human Human -DTXSID7041621 Css NA 1.24 mg/L PBTK NA 95% Human Human -DTXSID7041621 Clint NA 33.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041621 Fup NA 0.0799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041621 Vd NA 0.3598 L/kg 1compartment NA NA Rat Human +DTXSID7041621 TK.Half.Life NA 2.248 hours 1compartment NA NA Human Human +DTXSID7041621 Css NA 0.5372 mg/L 3compartmentss NA 50% Human Human +DTXSID7041621 Css NA 3.6 mg/L 3compartmentss NA 95% Human Human +DTXSID7041621 Css NA 0.3657 mg/L PBTK NA 50% Human Human +DTXSID7041621 Css NA 2.267 mg/L PBTK NA 95% Human Human +DTXSID7041621 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041621 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041621 Vd NA 0.4935 L/kg 1compartment NA NA Rat Human DTXSID7041621 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041621 TK.Half.Life NA 0.4857 hours 1compartment NA NA Rat Human -DTXSID7041621 Css NA 0.14 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041621 Css NA 0.9201 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041621 Css NA 0.08306 mg/L PBTK NA 50% Rat Human -DTXSID7041621 Css NA 0.522 mg/L PBTK NA 95% Rat Human +DTXSID7041621 TK.Half.Life NA 1.335 hours 1compartment NA NA Rat Human +DTXSID7041621 Css NA 0.06465 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041621 Css NA 0.3457 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041621 Css NA 0.04336 mg/L PBTK NA 50% Rat Human +DTXSID7041621 Css NA 0.208 mg/L PBTK NA 95% Rat Human DTXSID7041623 Clint 21.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID7041623 Fup 0.07513 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID7041623 Vd NA 1.501 L/kg 1compartment NA NA Human Human +DTXSID7041623 Vd NA 1.487 L/kg 1compartment NA NA Human Human DTXSID7041623 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041623 TK.Half.Life NA 5.291 hours 1compartment NA NA Human Human -DTXSID7041623 Css NA 0.437 mg/L 3compartmentss NA 50% Human Human -DTXSID7041623 Css NA 3.172 mg/L 3compartmentss NA 95% Human Human -DTXSID7041623 Css NA 0.2852 mg/L PBTK NA 50% Human Human -DTXSID7041623 Css NA 1.986 mg/L PBTK NA 95% Human Human +DTXSID7041623 TK.Half.Life NA 5.227 hours 1compartment NA NA Human Human +DTXSID7041623 Css NA 0.42 mg/L 3compartmentss NA 50% Human Human +DTXSID7041623 Css NA 3.088 mg/L 3compartmentss NA 95% Human Human +DTXSID7041623 Css NA 0.2738 mg/L PBTK NA 50% Human Human +DTXSID7041623 Css NA 1.942 mg/L PBTK NA 95% Human Human DTXSID7041623 Clint 21.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID7041623 Fup 0.07513 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID7041623 Vd NA 1.139 L/kg 1compartment NA NA Rat Human +DTXSID7041623 Vd NA 1.129 L/kg 1compartment NA NA Rat Human DTXSID7041623 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041623 TK.Half.Life NA 2.045 hours 1compartment NA NA Rat Human -DTXSID7041623 Css NA 0.2466 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041623 Css NA 1.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041623 Css NA 0.1508 mg/L PBTK NA 50% Rat Human -DTXSID7041623 Css NA 0.7976 mg/L PBTK NA 95% Rat Human -DTXSID7041625 Clint NA 0.2554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041625 Fup NA 0.2342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041625 Vd NA 0.3694 L/kg 1compartment NA NA Human Human +DTXSID7041623 TK.Half.Life NA 2.028 hours 1compartment NA NA Rat Human +DTXSID7041623 Css NA 0.05496 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041623 Css NA 0.3108 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041623 Css NA 0.03488 mg/L PBTK NA 50% Rat Human +DTXSID7041623 Css NA 0.1895 mg/L PBTK NA 95% Rat Human +DTXSID7041625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041625 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041625 Vd NA 0.4439 L/kg 1compartment NA NA Human Human DTXSID7041625 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041625 TK.Half.Life NA 6.967 hours 1compartment NA NA Human Human -DTXSID7041625 Css NA 2.242 mg/L 3compartmentss NA 50% Human Human -DTXSID7041625 Css NA 8.603 mg/L 3compartmentss NA 95% Human Human -DTXSID7041625 Css NA 1.497 mg/L PBTK NA 50% Human Human -DTXSID7041625 Css NA 5.239 mg/L PBTK NA 95% Human Human -DTXSID7041625 Clint NA 0.2554 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041625 Fup NA 0.2342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041625 Vd NA 0.3804 L/kg 1compartment NA NA Rat Human +DTXSID7041625 TK.Half.Life NA 0.5336 hours 1compartment NA NA Human Human +DTXSID7041625 Css NA 0.0452 mg/L 3compartmentss NA 50% Human Human +DTXSID7041625 Css NA 0.3736 mg/L 3compartmentss NA 95% Human Human +DTXSID7041625 Css NA 0.03163 mg/L PBTK NA 50% Human Human +DTXSID7041625 Css NA 0.2448 mg/L PBTK NA 95% Human Human +DTXSID7041625 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041625 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041625 Vd NA 0.4589 L/kg 1compartment NA NA Rat Human DTXSID7041625 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041625 TK.Half.Life NA 2.919 hours 1compartment NA NA Rat Human -DTXSID7041625 Css NA 0.766 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041625 Css NA 2.445 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041625 Css NA 0.4826 mg/L PBTK NA 50% Rat Human -DTXSID7041625 Css NA 1.395 mg/L PBTK NA 95% Rat Human -DTXSID7041627 Clint NA 21.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041627 Fup NA 0.3712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041627 Vd NA 0.7285 L/kg 1compartment NA NA Human Human +DTXSID7041625 TK.Half.Life NA 0.2852 hours 1compartment NA NA Rat Human +DTXSID7041625 Css NA 0.002083 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041625 Css NA 0.02031 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041625 Css NA 0.001459 mg/L PBTK NA 50% Rat Human +DTXSID7041625 Css NA 0.01294 mg/L PBTK NA 95% Rat Human +DTXSID7041627 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041627 Fup 0.618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041627 Vd NA 0.9939 L/kg 1compartment NA NA Human Human DTXSID7041627 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041627 TK.Half.Life NA 0.845 hours 1compartment NA NA Human Human -DTXSID7041627 Css NA 0.05628 mg/L 3compartmentss NA 50% Human Human -DTXSID7041627 Css NA 0.4107 mg/L 3compartmentss NA 95% Human Human -DTXSID7041627 Css NA 0.04173 mg/L PBTK NA 50% Human Human -DTXSID7041627 Css NA 0.2839 mg/L PBTK NA 95% Human Human -DTXSID7041627 Clint NA 21.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041627 Fup NA 0.3712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041627 Vd NA 0.6947 L/kg 1compartment NA NA Rat Human +DTXSID7041627 TK.Half.Life NA 1.445 hours 1compartment NA NA Human Human +DTXSID7041627 Css NA 0.1049 mg/L 3compartmentss NA 50% Human Human +DTXSID7041627 Css NA 0.9716 mg/L 3compartmentss NA 95% Human Human +DTXSID7041627 Css NA 0.0875 mg/L PBTK NA 50% Human Human +DTXSID7041627 Css NA 0.6767 mg/L PBTK NA 95% Human Human +DTXSID7041627 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041627 Fup 0.618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041627 Vd NA 0.9499 L/kg 1compartment NA NA Rat Human DTXSID7041627 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041627 TK.Half.Life NA 0.4176 hours 1compartment NA NA Rat Human -DTXSID7041627 Css NA 0.02976 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041627 Css NA 0.1813 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041627 Css NA 0.02144 mg/L PBTK NA 50% Rat Human -DTXSID7041627 Css NA 0.1174 mg/L PBTK NA 95% Rat Human -DTXSID7041629 Clint NA 218.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041629 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041629 Vd NA 1.189 L/kg 1compartment NA NA Human Human -DTXSID7041629 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041629 TK.Half.Life NA 3.039 hours 1compartment NA NA Human Human -DTXSID7041629 Css NA 0.2936 mg/L 3compartmentss NA 50% Human Human -DTXSID7041629 Css NA 2.92 mg/L 3compartmentss NA 95% Human Human -DTXSID7041629 Css NA 0.1825 mg/L PBTK NA 50% Human Human -DTXSID7041629 Css NA 1.726 mg/L PBTK NA 95% Human Human -DTXSID7041629 Clint NA 218.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041629 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041629 Vd NA 0.8818 L/kg 1compartment NA NA Rat Human +DTXSID7041627 TK.Half.Life NA 0.7386 hours 1compartment NA NA Rat Human +DTXSID7041627 Css NA 0.0118 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041627 Css NA 0.09386 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041627 Css NA 0.009932 mg/L PBTK NA 50% Rat Human +DTXSID7041627 Css NA 0.05935 mg/L PBTK NA 95% Rat Human +DTXSID7041629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041629 Fup 0.00346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041629 Vd NA 0.2098 L/kg 1compartment NA NA Human Human +DTXSID7041629 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7041629 TK.Half.Life NA 10.15 hours 1compartment NA NA Human Human +DTXSID7041629 Css NA 9 mg/L 3compartmentss NA 50% Human Human +DTXSID7041629 Css NA 74.61 mg/L 3compartmentss NA 95% Human Human +DTXSID7041629 Css NA 5.265 mg/L PBTK NA 50% Human Human +DTXSID7041629 Css NA 42.87 mg/L PBTK NA 95% Human Human +DTXSID7041629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041629 Fup 0.00346 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041629 Vd NA 0.1902 L/kg 1compartment NA NA Rat Human DTXSID7041629 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041629 TK.Half.Life NA 1.207 hours 1compartment NA NA Rat Human -DTXSID7041629 Css NA 0.1708 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041629 Css NA 1.437 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041629 Css NA 0.09902 mg/L PBTK NA 50% Rat Human -DTXSID7041629 Css NA 0.7996 mg/L PBTK NA 95% Rat Human -DTXSID7041675 Clint NA 8.715 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041675 Fup NA 0.1644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041675 Vd NA 2.697 L/kg 1compartment NA NA Human Human -DTXSID7041675 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7041675 TK.Half.Life NA 21.63 hours 1compartment NA NA Human Human -DTXSID7041675 Css NA 0.9288 mg/L 3compartmentss NA 50% Human Human -DTXSID7041675 Css NA 4.962 mg/L 3compartmentss NA 95% Human Human -DTXSID7041675 Css NA 0.6592 mg/L PBTK NA 50% Human Human -DTXSID7041675 Css NA 3.32 mg/L PBTK NA 95% Human Human -DTXSID7041675 Clint NA 8.715 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041675 Fup NA 0.1644 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041675 Vd NA 2.04 L/kg 1compartment NA NA Rat Human -DTXSID7041675 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7041675 TK.Half.Life NA 4.79 hours 1compartment NA NA Rat Human -DTXSID7041675 Css NA 0.4913 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041675 Css NA 1.992 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041675 Css NA 0.3347 mg/L PBTK NA 50% Rat Human -DTXSID7041675 Css NA 1.299 mg/L PBTK NA 95% Rat Human -DTXSID7041708 Clint NA 168.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041708 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041708 Vd NA 0.2118 L/kg 1compartment NA NA Human Human -DTXSID7041708 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041708 TK.Half.Life NA 1.115 hours 1compartment NA NA Human Human -DTXSID7041708 Css NA 0.8234 mg/L 3compartmentss NA 50% Human Human -DTXSID7041708 Css NA 8.628 mg/L 3compartmentss NA 95% Human Human -DTXSID7041708 Css NA 0.483 mg/L PBTK NA 50% Human Human -DTXSID7041708 Css NA 5.064 mg/L PBTK NA 95% Human Human -DTXSID7041708 Clint NA 168.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041708 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041708 Vd NA 0.2038 L/kg 1compartment NA NA Rat Human -DTXSID7041708 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041708 TK.Half.Life NA 0.698 hours 1compartment NA NA Rat Human -DTXSID7041708 Css NA 0.4858 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041708 Css NA 4.366 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041708 Css NA 0.266 mg/L PBTK NA 50% Rat Human -DTXSID7041708 Css NA 2.383 mg/L PBTK NA 95% Rat Human -DTXSID7041752 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041752 Fup NA 0.8403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041752 Vd NA 0.9086 L/kg 1compartment NA NA Human Human -DTXSID7041752 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041752 TK.Half.Life NA 1.041 hours 1compartment NA NA Human Human -DTXSID7041752 Css NA 0.08588 mg/L 3compartmentss NA 50% Human Human -DTXSID7041752 Css NA 0.7219 mg/L 3compartmentss NA 95% Human Human -DTXSID7041752 Css NA 0.07262 mg/L PBTK NA 50% Human Human -DTXSID7041752 Css NA 0.5061 mg/L PBTK NA 95% Human Human -DTXSID7041752 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041752 Fup NA 0.8403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041752 Vd NA 0.9083 L/kg 1compartment NA NA Rat Human +DTXSID7041629 TK.Half.Life NA 6.239 hours 1compartment NA NA Rat Human +DTXSID7041629 Css NA 1.187 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041629 Css NA 7.594 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041629 Css NA 0.6679 mg/L PBTK NA 50% Rat Human +DTXSID7041629 Css NA 4.251 mg/L PBTK NA 95% Rat Human +DTXSID7041752 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041752 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041752 Vd NA 0.6209 L/kg 1compartment NA NA Human Human +DTXSID7041752 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7041752 TK.Half.Life NA 9.534 hours 1compartment NA NA Human Human +DTXSID7041752 Css NA 1.65 mg/L 3compartmentss NA 50% Human Human +DTXSID7041752 Css NA 7.512 mg/L 3compartmentss NA 95% Human Human +DTXSID7041752 Css NA 1.233 mg/L PBTK NA 50% Human Human +DTXSID7041752 Css NA 4.777 mg/L PBTK NA 95% Human Human +DTXSID7041752 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041752 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041752 Vd NA 0.6149 L/kg 1compartment NA NA Rat Human DTXSID7041752 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041752 TK.Half.Life NA 0.5454 hours 1compartment NA NA Rat Human -DTXSID7041752 Css NA 0.04078 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041752 Css NA 0.2994 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041752 Css NA 0.03402 mg/L PBTK NA 50% Rat Human -DTXSID7041752 Css NA 0.1927 mg/L PBTK NA 95% Rat Human -DTXSID7041756 Clint NA 9.745 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041756 Fup NA 0.2418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041756 Vd NA 0.8637 L/kg 1compartment NA NA Human Human +DTXSID7041752 TK.Half.Life NA 3.202 hours 1compartment NA NA Rat Human +DTXSID7041752 Css NA 0.1045 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041752 Css NA 0.4144 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041752 Css NA 0.07775 mg/L PBTK NA 50% Rat Human +DTXSID7041752 Css NA 0.2552 mg/L PBTK NA 95% Rat Human +DTXSID7041756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041756 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041756 Vd NA 1.249 L/kg 1compartment NA NA Human Human DTXSID7041756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041756 TK.Half.Life NA 1.98 hours 1compartment NA NA Human Human -DTXSID7041756 Css NA 0.1976 mg/L 3compartmentss NA 50% Human Human -DTXSID7041756 Css NA 1.315 mg/L 3compartmentss NA 95% Human Human -DTXSID7041756 Css NA 0.1406 mg/L PBTK NA 50% Human Human -DTXSID7041756 Css NA 0.8639 mg/L PBTK NA 95% Human Human -DTXSID7041756 Clint NA 9.745 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041756 Fup NA 0.2418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041756 Vd NA 0.7439 L/kg 1compartment NA NA Rat Human +DTXSID7041756 TK.Half.Life NA 1.277 hours 1compartment NA NA Human Human +DTXSID7041756 Css NA 0.04197 mg/L 3compartmentss NA 50% Human Human +DTXSID7041756 Css NA 0.3674 mg/L 3compartmentss NA 95% Human Human +DTXSID7041756 Css NA 0.03402 mg/L PBTK NA 50% Human Human +DTXSID7041756 Css NA 0.2553 mg/L PBTK NA 95% Human Human +DTXSID7041756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041756 Fup 0.472 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041756 Vd NA 1.083 L/kg 1compartment NA NA Rat Human DTXSID7041756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041756 TK.Half.Life NA 0.9515 hours 1compartment NA NA Rat Human -DTXSID7041756 Css NA 0.1038 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041756 Css NA 0.4787 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041756 Css NA 0.07081 mg/L PBTK NA 50% Rat Human -DTXSID7041756 Css NA 0.3025 mg/L PBTK NA 95% Rat Human -DTXSID7041883 Clint NA 0.204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041883 Fup NA 0.0347 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041883 Vd NA 0.2785 L/kg 1compartment NA NA Human Human -DTXSID7041883 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID7041883 TK.Half.Life NA 38.77 hours 1compartment NA NA Human Human -DTXSID7041883 Css NA 23.84 mg/L 3compartmentss NA 50% Human Human -DTXSID7041883 Css NA 110 mg/L 3compartmentss NA 95% Human Human -DTXSID7041883 Css NA 14.45 mg/L PBTK NA 50% Human Human -DTXSID7041883 Css NA 63.95 mg/L PBTK NA 95% Human Human -DTXSID7041883 Clint NA 0.204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041883 Fup NA 0.0347 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041883 Vd NA 0.2631 L/kg 1compartment NA NA Rat Human -DTXSID7041883 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7041883 TK.Half.Life NA 14.34 hours 1compartment NA NA Rat Human -DTXSID7041883 Css NA 7.92 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041883 Css NA 31.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041883 Css NA 4.467 mg/L PBTK NA 50% Rat Human -DTXSID7041883 Css NA 16.95 mg/L PBTK NA 95% Rat Human -DTXSID7041887 Clint NA 26.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041887 Fup NA 0.3345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041887 Vd NA 0.9166 L/kg 1compartment NA NA Human Human -DTXSID7041887 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041887 TK.Half.Life NA 1.069 hours 1compartment NA NA Human Human -DTXSID7041887 Css NA 0.0547 mg/L 3compartmentss NA 50% Human Human -DTXSID7041887 Css NA 0.402 mg/L 3compartmentss NA 95% Human Human -DTXSID7041887 Css NA 0.04005 mg/L PBTK NA 50% Human Human -DTXSID7041887 Css NA 0.2731 mg/L PBTK NA 95% Human Human -DTXSID7041887 Clint NA 26.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041887 Fup NA 0.3345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041887 Vd NA 0.7788 L/kg 1compartment NA NA Rat Human +DTXSID7041756 TK.Half.Life NA 0.5471 hours 1compartment NA NA Rat Human +DTXSID7041756 Css NA 0.005092 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041756 Css NA 0.03553 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041756 Css NA 0.004157 mg/L PBTK NA 50% Rat Human +DTXSID7041756 Css NA 0.02443 mg/L PBTK NA 95% Rat Human +DTXSID7041883 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041883 Fup 0.0225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041883 Vd NA 0.2428 L/kg 1compartment NA NA Human Human +DTXSID7041883 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7041883 TK.Half.Life NA 2.084 hours 1compartment NA NA Human Human +DTXSID7041883 Css NA 1.42 mg/L 3compartmentss NA 50% Human Human +DTXSID7041883 Css NA 14.15 mg/L 3compartmentss NA 95% Human Human +DTXSID7041883 Css NA 0.8412 mg/L PBTK NA 50% Human Human +DTXSID7041883 Css NA 8.284 mg/L PBTK NA 95% Human Human +DTXSID7041883 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041883 Fup 0.0225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041883 Vd NA 0.2302 L/kg 1compartment NA NA Rat Human +DTXSID7041883 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7041883 TK.Half.Life NA 1.292 hours 1compartment NA NA Rat Human +DTXSID7041883 Css NA 0.1859 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041883 Css NA 1.526 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041883 Css NA 0.1071 mg/L PBTK NA 50% Rat Human +DTXSID7041883 Css NA 0.8632 mg/L PBTK NA 95% Rat Human +DTXSID7041887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041887 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041887 Vd NA 0.8374 L/kg 1compartment NA NA Human Human +DTXSID7041887 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7041887 TK.Half.Life NA 19.84 hours 1compartment NA NA Human Human +DTXSID7041887 Css NA 2.318 mg/L 3compartmentss NA 50% Human Human +DTXSID7041887 Css NA 9.294 mg/L 3compartmentss NA 95% Human Human +DTXSID7041887 Css NA 1.668 mg/L PBTK NA 50% Human Human +DTXSID7041887 Css NA 5.871 mg/L PBTK NA 95% Human Human +DTXSID7041887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041887 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041887 Vd NA 0.7126 L/kg 1compartment NA NA Rat Human DTXSID7041887 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041887 TK.Half.Life NA 0.4587 hours 1compartment NA NA Rat Human -DTXSID7041887 Css NA 0.02969 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041887 Css NA 0.165 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041887 Css NA 0.02093 mg/L PBTK NA 50% Rat Human -DTXSID7041887 Css NA 0.1041 mg/L PBTK NA 95% Rat Human -DTXSID7041889 Clint NA 34.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041889 Fup NA 0.1692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041889 Vd NA 2.787 L/kg 1compartment NA NA Human Human +DTXSID7041887 TK.Half.Life NA 5.471 hours 1compartment NA NA Rat Human +DTXSID7041887 Css NA 0.0561 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041887 Css NA 0.3083 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041887 Css NA 0.03996 mg/L PBTK NA 50% Rat Human +DTXSID7041887 Css NA 0.1938 mg/L PBTK NA 95% Rat Human +DTXSID7041889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041889 Fup 0.0441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041889 Vd NA 1.255 L/kg 1compartment NA NA Human Human DTXSID7041889 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041889 TK.Half.Life NA 8.144 hours 1compartment NA NA Human Human -DTXSID7041889 Css NA 0.264 mg/L 3compartmentss NA 50% Human Human -DTXSID7041889 Css NA 1.662 mg/L 3compartmentss NA 95% Human Human -DTXSID7041889 Css NA 0.1884 mg/L PBTK NA 50% Human Human -DTXSID7041889 Css NA 1.133 mg/L PBTK NA 95% Human Human -DTXSID7041889 Clint NA 34.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041889 Fup NA 0.1692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041889 Vd NA 2.106 L/kg 1compartment NA NA Rat Human +DTXSID7041889 TK.Half.Life NA 6.189 hours 1compartment NA NA Human Human +DTXSID7041889 Css NA 0.6757 mg/L 3compartmentss NA 50% Human Human +DTXSID7041889 Css NA 6.006 mg/L 3compartmentss NA 95% Human Human +DTXSID7041889 Css NA 0.4268 mg/L PBTK NA 50% Human Human +DTXSID7041889 Css NA 3.566 mg/L PBTK NA 95% Human Human +DTXSID7041889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041889 Fup 0.0441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041889 Vd NA 0.9453 L/kg 1compartment NA NA Rat Human DTXSID7041889 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041889 TK.Half.Life NA 1.911 hours 1compartment NA NA Rat Human -DTXSID7041889 Css NA 0.1459 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041889 Css NA 0.729 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041889 Css NA 0.09978 mg/L PBTK NA 50% Rat Human -DTXSID7041889 Css NA 0.4779 mg/L PBTK NA 95% Rat Human -DTXSID7041910 Clint NA 33.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041910 Fup NA 0.0226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041910 Vd NA 1.584 L/kg 1compartment NA NA Human Human +DTXSID7041889 TK.Half.Life NA 2.549 hours 1compartment NA NA Rat Human +DTXSID7041889 Css NA 0.08903 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041889 Css NA 0.6012 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041889 Css NA 0.05446 mg/L PBTK NA 50% Rat Human +DTXSID7041889 Css NA 0.3516 mg/L PBTK NA 95% Rat Human +DTXSID7041910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041910 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041910 Vd NA 1.808 L/kg 1compartment NA NA Human Human DTXSID7041910 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041910 TK.Half.Life NA 9.352 hours 1compartment NA NA Human Human -DTXSID7041910 Css NA 0.8647 mg/L 3compartmentss NA 50% Human Human -DTXSID7041910 Css NA 7.571 mg/L 3compartmentss NA 95% Human Human -DTXSID7041910 Css NA 0.5438 mg/L PBTK NA 50% Human Human -DTXSID7041910 Css NA 4.626 mg/L PBTK NA 95% Human Human -DTXSID7041910 Clint NA 33.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041910 Fup NA 0.0226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041910 Vd NA 1.176 L/kg 1compartment NA NA Rat Human +DTXSID7041910 TK.Half.Life NA 12.77 hours 1compartment NA NA Human Human +DTXSID7041910 Css NA 1.022 mg/L 3compartmentss NA 50% Human Human +DTXSID7041910 Css NA 8.771 mg/L 3compartmentss NA 95% Human Human +DTXSID7041910 Css NA 0.6544 mg/L PBTK NA 50% Human Human +DTXSID7041910 Css NA 5.437 mg/L PBTK NA 95% Human Human +DTXSID7041910 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041910 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041910 Vd NA 1.348 L/kg 1compartment NA NA Rat Human DTXSID7041910 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041910 TK.Half.Life NA 3.501 hours 1compartment NA NA Rat Human -DTXSID7041910 Css NA 0.4942 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041910 Css NA 3.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041910 Css NA 0.292 mg/L PBTK NA 50% Rat Human -DTXSID7041910 Css NA 2.025 mg/L PBTK NA 95% Rat Human +DTXSID7041910 TK.Half.Life NA 4.455 hours 1compartment NA NA Rat Human +DTXSID7041910 Css NA 0.132 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041910 Css NA 0.8455 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041910 Css NA 0.08281 mg/L PBTK NA 50% Rat Human +DTXSID7041910 Css NA 0.5065 mg/L PBTK NA 95% Rat Human DTXSID7041914 Clint NA 11.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7041914 Fup NA 0.906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041914 Vd NA 2.21 L/kg 1compartment NA NA Human Human +DTXSID7041914 Vd NA 1.455 L/kg 1compartment NA NA Human Human DTXSID7041914 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041914 TK.Half.Life NA 1.7 hours 1compartment NA NA Human Human -DTXSID7041914 Css NA 0.04173 mg/L 3compartmentss NA 50% Human Human -DTXSID7041914 Css NA 0.3759 mg/L 3compartmentss NA 95% Human Human -DTXSID7041914 Css NA 0.04266 mg/L PBTK NA 50% Human Human -DTXSID7041914 Css NA 0.3012 mg/L PBTK NA 95% Human Human +DTXSID7041914 TK.Half.Life NA 1.176 hours 1compartment NA NA Human Human +DTXSID7041914 Css NA 0.03417 mg/L 3compartmentss NA 50% Human Human +DTXSID7041914 Css NA 0.3494 mg/L 3compartmentss NA 95% Human Human +DTXSID7041914 Css NA 0.03178 mg/L PBTK NA 50% Human Human +DTXSID7041914 Css NA 0.2699 mg/L PBTK NA 95% Human Human DTXSID7041914 Clint NA 11.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7041914 Fup NA 0.906 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041914 Vd NA 2.248 L/kg 1compartment NA NA Rat Human +DTXSID7041914 Vd NA 1.505 L/kg 1compartment NA NA Rat Human DTXSID7041914 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041914 TK.Half.Life NA 0.9034 hours 1compartment NA NA Rat Human -DTXSID7041914 Css NA 0.01978 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041914 Css NA 0.1595 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041914 Css NA 0.02065 mg/L PBTK NA 50% Rat Human -DTXSID7041914 Css NA 0.1209 mg/L PBTK NA 95% Rat Human -DTXSID7041916 Clint NA 249.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041916 Fup NA 0.2208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041916 Vd NA 0.7693 L/kg 1compartment NA NA Human Human +DTXSID7041914 TK.Half.Life NA 0.6245 hours 1compartment NA NA Rat Human +DTXSID7041914 Css NA 0.001179 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041914 Css NA 0.01364 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041914 Css NA 0.001099 mg/L PBTK NA 50% Rat Human +DTXSID7041914 Css NA 0.01002 mg/L PBTK NA 95% Rat Human +DTXSID7041916 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041916 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041916 Vd NA 1.37 L/kg 1compartment NA NA Human Human DTXSID7041916 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041916 TK.Half.Life NA 0.662 hours 1compartment NA NA Human Human -DTXSID7041916 Css NA 0.009152 mg/L 3compartmentss NA 50% Human Human -DTXSID7041916 Css NA 0.06909 mg/L 3compartmentss NA 95% Human Human -DTXSID7041916 Css NA 0.00637 mg/L PBTK NA 50% Human Human -DTXSID7041916 Css NA 0.04558 mg/L PBTK NA 95% Human Human -DTXSID7041916 Clint NA 249.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041916 Fup NA 0.2208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041916 Vd NA 0.6702 L/kg 1compartment NA NA Rat Human +DTXSID7041916 TK.Half.Life NA 1.581 hours 1compartment NA NA Human Human +DTXSID7041916 Css NA 0.05362 mg/L 3compartmentss NA 50% Human Human +DTXSID7041916 Css NA 0.3937 mg/L 3compartmentss NA 95% Human Human +DTXSID7041916 Css NA 0.04198 mg/L PBTK NA 50% Human Human +DTXSID7041916 Css NA 0.2778 mg/L PBTK NA 95% Human Human +DTXSID7041916 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041916 Fup 0.391 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041916 Vd NA 1.148 L/kg 1compartment NA NA Rat Human DTXSID7041916 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041916 TK.Half.Life NA 0.2613 hours 1compartment NA NA Rat Human -DTXSID7041916 Css NA 0.00508 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041916 Css NA 0.03077 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041916 Css NA 0.00338 mg/L PBTK NA 50% Rat Human -DTXSID7041916 Css NA 0.01893 mg/L PBTK NA 95% Rat Human -DTXSID7041918 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041918 Fup NA 0.9484 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041918 Vd NA 0.8141 L/kg 1compartment NA NA Human Human +DTXSID7041916 TK.Half.Life NA 0.6527 hours 1compartment NA NA Rat Human +DTXSID7041916 Css NA 0.006551 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041916 Css NA 0.04007 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041916 Css NA 0.00522 mg/L PBTK NA 50% Rat Human +DTXSID7041916 Css NA 0.02835 mg/L PBTK NA 95% Rat Human +DTXSID7041918 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041918 Fup 0.735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041918 Vd NA 0.698 L/kg 1compartment NA NA Human Human DTXSID7041918 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041918 TK.Half.Life NA 5.563 hours 1compartment NA NA Human Human -DTXSID7041918 Css NA 0.8932 mg/L 3compartmentss NA 50% Human Human -DTXSID7041918 Css NA 4.919 mg/L 3compartmentss NA 95% Human Human -DTXSID7041918 Css NA 0.7515 mg/L PBTK NA 50% Human Human -DTXSID7041918 Css NA 3.283 mg/L PBTK NA 95% Human Human -DTXSID7041918 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041918 Fup NA 0.9484 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041918 Vd NA 0.8419 L/kg 1compartment NA NA Rat Human +DTXSID7041918 TK.Half.Life NA 6.15 hours 1compartment NA NA Human Human +DTXSID7041918 Css NA 1.024 mg/L 3compartmentss NA 50% Human Human +DTXSID7041918 Css NA 6.64 mg/L 3compartmentss NA 95% Human Human +DTXSID7041918 Css NA 0.8292 mg/L PBTK NA 50% Human Human +DTXSID7041918 Css NA 4.189 mg/L PBTK NA 95% Human Human +DTXSID7041918 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041918 Fup 0.735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041918 Vd NA 0.7211 L/kg 1compartment NA NA Rat Human DTXSID7041918 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041918 TK.Half.Life NA 1.958 hours 1compartment NA NA Rat Human -DTXSID7041918 Css NA 0.2249 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041918 Css NA 1.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041918 Css NA 0.1849 mg/L PBTK NA 50% Rat Human -DTXSID7041918 Css NA 0.7227 mg/L PBTK NA 95% Rat Human -DTXSID7041964 Clint NA 222.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041964 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041964 Vd NA 0.4246 L/kg 1compartment NA NA Human Human +DTXSID7041918 TK.Half.Life NA 2.164 hours 1compartment NA NA Rat Human +DTXSID7041918 Css NA 0.06122 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041918 Css NA 0.3809 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041918 Css NA 0.04974 mg/L PBTK NA 50% Rat Human +DTXSID7041918 Css NA 0.2332 mg/L PBTK NA 95% Rat Human +DTXSID7041964 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041964 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041964 Vd NA 1.446 L/kg 1compartment NA NA Human Human DTXSID7041964 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041964 TK.Half.Life NA 0.5454 hours 1compartment NA NA Human Human -DTXSID7041964 Css NA 0.06579 mg/L 3compartmentss NA 50% Human Human -DTXSID7041964 Css NA 0.6384 mg/L 3compartmentss NA 95% Human Human -DTXSID7041964 Css NA 0.04019 mg/L PBTK NA 50% Human Human -DTXSID7041964 Css NA 0.3738 mg/L PBTK NA 95% Human Human -DTXSID7041964 Clint NA 222.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041964 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041964 Vd NA 0.4162 L/kg 1compartment NA NA Rat Human +DTXSID7041964 TK.Half.Life NA 3.191 hours 1compartment NA NA Human Human +DTXSID7041964 Css NA 0.1667 mg/L 3compartmentss NA 50% Human Human +DTXSID7041964 Css NA 1.141 mg/L 3compartmentss NA 95% Human Human +DTXSID7041964 Css NA 0.1389 mg/L PBTK NA 50% Human Human +DTXSID7041964 Css NA 0.8371 mg/L PBTK NA 95% Human Human +DTXSID7041964 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041964 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041964 Vd NA 1.452 L/kg 1compartment NA NA Rat Human DTXSID7041964 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041964 TK.Half.Life NA 0.2727 hours 1compartment NA NA Rat Human -DTXSID7041964 Css NA 0.03867 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041964 Css NA 0.2792 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041964 Css NA 0.02205 mg/L PBTK NA 50% Rat Human -DTXSID7041964 Css NA 0.1552 mg/L PBTK NA 95% Rat Human -DTXSID7041966 Clint NA 136.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041966 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7041966 Vd NA 0.6479 L/kg 1compartment NA NA Human Human +DTXSID7041964 TK.Half.Life NA 1.839 hours 1compartment NA NA Rat Human +DTXSID7041964 Css NA 0.01942 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041964 Css NA 0.101 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041964 Css NA 0.01628 mg/L PBTK NA 50% Rat Human +DTXSID7041964 Css NA 0.07008 mg/L PBTK NA 95% Rat Human +DTXSID7041966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041966 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7041966 Vd NA 1.34 L/kg 1compartment NA NA Human Human DTXSID7041966 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7041966 TK.Half.Life NA 0.9631 hours 1compartment NA NA Human Human -DTXSID7041966 Css NA 0.1032 mg/L 3compartmentss NA 50% Human Human -DTXSID7041966 Css NA 0.9743 mg/L 3compartmentss NA 95% Human Human -DTXSID7041966 Css NA 0.06321 mg/L PBTK NA 50% Human Human -DTXSID7041966 Css NA 0.5789 mg/L PBTK NA 95% Human Human -DTXSID7041966 Clint NA 136.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041966 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7041966 Vd NA 0.5128 L/kg 1compartment NA NA Rat Human +DTXSID7041966 TK.Half.Life NA 2.346 hours 1compartment NA NA Human Human +DTXSID7041966 Css NA 0.1192 mg/L 3compartmentss NA 50% Human Human +DTXSID7041966 Css NA 0.8877 mg/L 3compartmentss NA 95% Human Human +DTXSID7041966 Css NA 0.08502 mg/L PBTK NA 50% Human Human +DTXSID7041966 Css NA 0.59 mg/L PBTK NA 95% Human Human +DTXSID7041966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041966 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7041966 Vd NA 1.067 L/kg 1compartment NA NA Rat Human DTXSID7041966 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7041966 TK.Half.Life NA 0.3997 hours 1compartment NA NA Rat Human -DTXSID7041966 Css NA 0.06019 mg/L 3compartmentss NA 50% Rat Human -DTXSID7041966 Css NA 0.4238 mg/L 3compartmentss NA 95% Rat Human -DTXSID7041966 Css NA 0.03451 mg/L PBTK NA 50% Rat Human -DTXSID7041966 Css NA 0.2362 mg/L PBTK NA 95% Rat Human +DTXSID7041966 TK.Half.Life NA 0.9532 hours 1compartment NA NA Rat Human +DTXSID7041966 Css NA 0.01517 mg/L 3compartmentss NA 50% Rat Human +DTXSID7041966 Css NA 0.07848 mg/L 3compartmentss NA 95% Rat Human +DTXSID7041966 Css NA 0.01071 mg/L PBTK NA 50% Rat Human +DTXSID7041966 Css NA 0.05183 mg/L PBTK NA 95% Rat Human DTXSID7042011 Clint 42.07 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID7042011 Fup 0.003219 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID7042011 Vd NA 0.1908 L/kg 1compartment NA NA Human Human +DTXSID7042011 Vd NA 0.1684 L/kg 1compartment NA NA Human Human DTXSID7042011 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7042011 TK.Half.Life NA 5.373 hours 1compartment NA NA Human Human -DTXSID7042011 Css NA 4.501 mg/L 3compartmentss NA 50% Human Human -DTXSID7042011 Css NA 41.13 mg/L 3compartmentss NA 95% Human Human -DTXSID7042011 Css NA 2.612 mg/L PBTK NA 50% Human Human -DTXSID7042011 Css NA 23.52 mg/L PBTK NA 95% Human Human +DTXSID7042011 TK.Half.Life NA 4.909 hours 1compartment NA NA Human Human +DTXSID7042011 Css NA 4.482 mg/L 3compartmentss NA 50% Human Human +DTXSID7042011 Css NA 42.23 mg/L 3compartmentss NA 95% Human Human +DTXSID7042011 Css NA 2.616 mg/L PBTK NA 50% Human Human +DTXSID7042011 Css NA 24.45 mg/L PBTK NA 95% Human Human DTXSID7042011 Clint 42.07 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID7042011 Fup 0.003219 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID7042011 Vd NA 0.1789 L/kg 1compartment NA NA Rat Human +DTXSID7042011 Vd NA 0.1651 L/kg 1compartment NA NA Rat Human DTXSID7042011 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042011 TK.Half.Life NA 3.438 hours 1compartment NA NA Rat Human -DTXSID7042011 Css NA 2.564 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042011 Css NA 18.59 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042011 Css NA 1.394 mg/L PBTK NA 50% Rat Human -DTXSID7042011 Css NA 10.05 mg/L PBTK NA 95% Rat Human -DTXSID7042019 Clint NA 8.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042019 Fup NA 0.0065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042019 Vd NA 0.2198 L/kg 1compartment NA NA Human Human -DTXSID7042019 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7042019 TK.Half.Life NA 14.59 hours 1compartment NA NA Human Human -DTXSID7042019 Css NA 12.42 mg/L 3compartmentss NA 50% Human Human -DTXSID7042019 Css NA 113.7 mg/L 3compartmentss NA 95% Human Human -DTXSID7042019 Css NA 7.316 mg/L PBTK NA 50% Human Human -DTXSID7042019 Css NA 65.95 mg/L PBTK NA 95% Human Human -DTXSID7042019 Clint NA 8.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042019 Fup NA 0.0065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042019 Vd NA 0.2114 L/kg 1compartment NA NA Rat Human +DTXSID7042011 TK.Half.Life NA 3.288 hours 1compartment NA NA Rat Human +DTXSID7042011 Css NA 0.5992 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042011 Css NA 4.469 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042011 Css NA 0.3362 mg/L PBTK NA 50% Rat Human +DTXSID7042011 Css NA 2.507 mg/L PBTK NA 95% Rat Human +DTXSID7042019 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042019 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042019 Vd NA 0.2874 L/kg 1compartment NA NA Human Human +DTXSID7042019 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7042019 TK.Half.Life NA 3.085 hours 1compartment NA NA Human Human +DTXSID7042019 Css NA 1.771 mg/L 3compartmentss NA 50% Human Human +DTXSID7042019 Css NA 17.37 mg/L 3compartmentss NA 95% Human Human +DTXSID7042019 Css NA 1.076 mg/L PBTK NA 50% Human Human +DTXSID7042019 Css NA 10.33 mg/L PBTK NA 95% Human Human +DTXSID7042019 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042019 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042019 Vd NA 0.2764 L/kg 1compartment NA NA Rat Human DTXSID7042019 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042019 TK.Half.Life NA 9.17 hours 1compartment NA NA Rat Human -DTXSID7042019 Css NA 6.792 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042019 Css NA 49.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042019 Css NA 3.735 mg/L PBTK NA 50% Rat Human -DTXSID7042019 Css NA 26.79 mg/L PBTK NA 95% Rat Human -DTXSID7042063 Clint NA 90.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042063 Fup NA 0.082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042063 Vd NA 0.8183 L/kg 1compartment NA NA Human Human +DTXSID7042019 TK.Half.Life NA 1.957 hours 1compartment NA NA Rat Human +DTXSID7042019 Css NA 0.2397 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042019 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042019 Css NA 0.1396 mg/L PBTK NA 50% Rat Human +DTXSID7042019 Css NA 1.05 mg/L PBTK NA 95% Rat Human +DTXSID7042063 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042063 Fup 0.0889 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042063 Vd NA 0.7385 L/kg 1compartment NA NA Human Human DTXSID7042063 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7042063 TK.Half.Life NA 1.134 hours 1compartment NA NA Human Human -DTXSID7042063 Css NA 0.08779 mg/L 3compartmentss NA 50% Human Human -DTXSID7042063 Css NA 0.7352 mg/L 3compartmentss NA 95% Human Human -DTXSID7042063 Css NA 0.05594 mg/L PBTK NA 50% Human Human -DTXSID7042063 Css NA 0.4561 mg/L PBTK NA 95% Human Human -DTXSID7042063 Clint NA 90.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042063 Fup NA 0.082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042063 Vd NA 0.6754 L/kg 1compartment NA NA Rat Human +DTXSID7042063 TK.Half.Life NA 2.076 hours 1compartment NA NA Human Human +DTXSID7042063 Css NA 0.3183 mg/L 3compartmentss NA 50% Human Human +DTXSID7042063 Css NA 2.534 mg/L 3compartmentss NA 95% Human Human +DTXSID7042063 Css NA 0.2012 mg/L PBTK NA 50% Human Human +DTXSID7042063 Css NA 1.516 mg/L PBTK NA 95% Human Human +DTXSID7042063 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042063 Fup 0.0889 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042063 Vd NA 0.5849 L/kg 1compartment NA NA Rat Human DTXSID7042063 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042063 TK.Half.Life NA 0.4844 hours 1compartment NA NA Rat Human -DTXSID7042063 Css NA 0.05051 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042063 Css NA 0.348 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042063 Css NA 0.03007 mg/L PBTK NA 50% Rat Human -DTXSID7042063 Css NA 0.1996 mg/L PBTK NA 95% Rat Human -DTXSID7042065 Clint NA 0.2033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042065 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042065 Vd NA 3.117 L/kg 1compartment NA NA Human Human -DTXSID7042065 Days.Css NA 2401 Days PBTK NA NA Human Human -DTXSID7042065 TK.Half.Life NA 8790 hours 1compartment NA NA Human Human -DTXSID7042065 Css NA 342 mg/L 3compartmentss NA 50% Human Human -DTXSID7042065 Css NA 1525 mg/L 3compartmentss NA 95% Human Human -DTXSID7042065 Css NA 237.3 mg/L PBTK NA 50% Human Human -DTXSID7042065 Css NA 1028 mg/L PBTK NA 95% Human Human -DTXSID7042065 Clint NA 0.2033 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042065 Fup NA 0.0187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042065 Vd NA 2.336 L/kg 1compartment NA NA Rat Human -DTXSID7042065 Days.Css NA 1173 Days PBTK NA NA Rat Human -DTXSID7042065 TK.Half.Life NA 1049 hours 1compartment NA NA Rat Human -DTXSID7042065 Css NA 177.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042065 Css NA 542.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042065 Css NA 117.9 mg/L PBTK NA 50% Rat Human -DTXSID7042065 Css NA 347.2 mg/L PBTK NA 95% Rat Human -DTXSID7042140 Clint NA 17.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042140 Fup NA 0.3363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042140 Vd NA 1.11 L/kg 1compartment NA NA Human Human +DTXSID7042063 TK.Half.Life NA 0.948 hours 1compartment NA NA Rat Human +DTXSID7042063 Css NA 0.04162 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042063 Css NA 0.2623 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042063 Css NA 0.02556 mg/L PBTK NA 50% Rat Human +DTXSID7042063 Css NA 0.1544 mg/L PBTK NA 95% Rat Human +DTXSID7042140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042140 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042140 Vd NA 0.9401 L/kg 1compartment NA NA Human Human DTXSID7042140 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7042140 TK.Half.Life NA 1.513 hours 1compartment NA NA Human Human -DTXSID7042140 Css NA 0.0808 mg/L 3compartmentss NA 50% Human Human -DTXSID7042140 Css NA 0.5652 mg/L 3compartmentss NA 95% Human Human -DTXSID7042140 Css NA 0.06152 mg/L PBTK NA 50% Human Human -DTXSID7042140 Css NA 0.3953 mg/L PBTK NA 95% Human Human -DTXSID7042140 Clint NA 17.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042140 Fup NA 0.3363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042140 Vd NA 0.9474 L/kg 1compartment NA NA Rat Human +DTXSID7042140 TK.Half.Life NA 1.076 hours 1compartment NA NA Human Human +DTXSID7042140 Css NA 0.05096 mg/L 3compartmentss NA 50% Human Human +DTXSID7042140 Css NA 0.3986 mg/L 3compartmentss NA 95% Human Human +DTXSID7042140 Css NA 0.03928 mg/L PBTK NA 50% Human Human +DTXSID7042140 Css NA 0.2688 mg/L PBTK NA 95% Human Human +DTXSID7042140 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042140 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042140 Vd NA 0.8389 L/kg 1compartment NA NA Rat Human DTXSID7042140 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042140 TK.Half.Life NA 0.6691 hours 1compartment NA NA Rat Human -DTXSID7042140 Css NA 0.04236 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042140 Css NA 0.233 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042140 Css NA 0.03107 mg/L PBTK NA 50% Rat Human -DTXSID7042140 Css NA 0.1535 mg/L PBTK NA 95% Rat Human -DTXSID7042146 Clint NA 78.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042146 Fup NA 0.0852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042146 Vd NA 1.12 L/kg 1compartment NA NA Human Human +DTXSID7042140 TK.Half.Life NA 0.4916 hours 1compartment NA NA Rat Human +DTXSID7042140 Css NA 0.006412 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042140 Css NA 0.03878 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042140 Css NA 0.004929 mg/L PBTK NA 50% Rat Human +DTXSID7042140 Css NA 0.02643 mg/L PBTK NA 95% Rat Human +DTXSID7042146 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042146 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042146 Vd NA 1.416 L/kg 1compartment NA NA Human Human DTXSID7042146 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7042146 TK.Half.Life NA 1.632 hours 1compartment NA NA Human Human -DTXSID7042146 Css NA 0.09928 mg/L 3compartmentss NA 50% Human Human -DTXSID7042146 Css NA 0.8175 mg/L 3compartmentss NA 95% Human Human -DTXSID7042146 Css NA 0.06393 mg/L PBTK NA 50% Human Human -DTXSID7042146 Css NA 0.5049 mg/L PBTK NA 95% Human Human -DTXSID7042146 Clint NA 78.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042146 Fup NA 0.0852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042146 Vd NA 0.8668 L/kg 1compartment NA NA Rat Human +DTXSID7042146 TK.Half.Life NA 3.777 hours 1compartment NA NA Human Human +DTXSID7042146 Css NA 0.2803 mg/L 3compartmentss NA 50% Human Human +DTXSID7042146 Css NA 2.175 mg/L 3compartmentss NA 95% Human Human +DTXSID7042146 Css NA 0.1848 mg/L PBTK NA 50% Human Human +DTXSID7042146 Css NA 1.392 mg/L PBTK NA 95% Human Human +DTXSID7042146 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042146 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042146 Vd NA 1.09 L/kg 1compartment NA NA Rat Human DTXSID7042146 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042146 TK.Half.Life NA 0.6388 hours 1compartment NA NA Rat Human -DTXSID7042146 Css NA 0.05732 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042146 Css NA 0.3814 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042146 Css NA 0.03461 mg/L PBTK NA 50% Rat Human -DTXSID7042146 Css NA 0.2216 mg/L PBTK NA 95% Rat Human -DTXSID7042196 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042196 Fup NA 0.6982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042196 Vd NA 1.449 L/kg 1compartment NA NA Human Human -DTXSID7042196 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7042196 TK.Half.Life NA 15.71 hours 1compartment NA NA Human Human -DTXSID7042196 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human -DTXSID7042196 Css NA 7.282 mg/L 3compartmentss NA 95% Human Human -DTXSID7042196 Css NA 0.9791 mg/L PBTK NA 50% Human Human -DTXSID7042196 Css NA 4.755 mg/L PBTK NA 95% Human Human -DTXSID7042196 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042196 Fup NA 0.6982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042196 Vd NA 1.257 L/kg 1compartment NA NA Rat Human +DTXSID7042146 TK.Half.Life NA 1.497 hours 1compartment NA NA Rat Human +DTXSID7042146 Css NA 0.03622 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042146 Css NA 0.2116 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042146 Css NA 0.02361 mg/L PBTK NA 50% Rat Human +DTXSID7042146 Css NA 0.1292 mg/L PBTK NA 95% Rat Human +DTXSID7042196 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042196 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042196 Vd NA 1.247 L/kg 1compartment NA NA Human Human +DTXSID7042196 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7042196 TK.Half.Life NA 1.054 hours 1compartment NA NA Human Human +DTXSID7042196 Css NA 0.02966 mg/L 3compartmentss NA 50% Human Human +DTXSID7042196 Css NA 0.321 mg/L 3compartmentss NA 95% Human Human +DTXSID7042196 Css NA 0.02532 mg/L PBTK NA 50% Human Human +DTXSID7042196 Css NA 0.2273 mg/L PBTK NA 95% Human Human +DTXSID7042196 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042196 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042196 Vd NA 1.11 L/kg 1compartment NA NA Rat Human DTXSID7042196 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042196 TK.Half.Life NA 4.131 hours 1compartment NA NA Rat Human -DTXSID7042196 Css NA 0.2915 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042196 Css NA 1.868 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042196 Css NA 0.2493 mg/L PBTK NA 50% Rat Human -DTXSID7042196 Css NA 1.138 mg/L PBTK NA 95% Rat Human -DTXSID7042198 Clint NA 6.134 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042198 Fup NA 0.131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042198 Vd NA 1.409 L/kg 1compartment NA NA Human Human +DTXSID7042196 TK.Half.Life NA 0.4519 hours 1compartment NA NA Rat Human +DTXSID7042196 Css NA 0.00352 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042196 Css NA 0.03314 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042196 Css NA 0.003083 mg/L PBTK NA 50% Rat Human +DTXSID7042196 Css NA 0.02282 mg/L PBTK NA 95% Rat Human +DTXSID7042198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042198 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042198 Vd NA 1.422 L/kg 1compartment NA NA Human Human DTXSID7042198 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7042198 TK.Half.Life NA 8.207 hours 1compartment NA NA Human Human -DTXSID7042198 Css NA 0.7588 mg/L 3compartmentss NA 50% Human Human -DTXSID7042198 Css NA 4.913 mg/L 3compartmentss NA 95% Human Human -DTXSID7042198 Css NA 0.514 mg/L PBTK NA 50% Human Human -DTXSID7042198 Css NA 3.113 mg/L PBTK NA 95% Human Human -DTXSID7042198 Clint NA 6.134 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042198 Fup NA 0.131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042198 Vd NA 1.094 L/kg 1compartment NA NA Rat Human +DTXSID7042198 TK.Half.Life NA 2.414 hours 1compartment NA NA Human Human +DTXSID7042198 Css NA 0.1139 mg/L 3compartmentss NA 50% Human Human +DTXSID7042198 Css NA 0.7678 mg/L 3compartmentss NA 95% Human Human +DTXSID7042198 Css NA 0.08189 mg/L PBTK NA 50% Human Human +DTXSID7042198 Css NA 0.5211 mg/L PBTK NA 95% Human Human +DTXSID7042198 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042198 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042198 Vd NA 1.131 L/kg 1compartment NA NA Rat Human DTXSID7042198 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042198 TK.Half.Life NA 3.262 hours 1compartment NA NA Rat Human -DTXSID7042198 Css NA 0.3985 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042198 Css NA 1.974 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042198 Css NA 0.2554 mg/L PBTK NA 50% Rat Human -DTXSID7042198 Css NA 1.148 mg/L PBTK NA 95% Rat Human -DTXSID7042273 Clint NA 23.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042273 Fup NA 0.0619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042273 Vd NA 2.704 L/kg 1compartment NA NA Human Human -DTXSID7042273 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7042273 TK.Half.Life NA 18.79 hours 1compartment NA NA Human Human -DTXSID7042273 Css NA 0.8623 mg/L 3compartmentss NA 50% Human Human -DTXSID7042273 Css NA 5.589 mg/L 3compartmentss NA 95% Human Human -DTXSID7042273 Css NA 0.5901 mg/L PBTK NA 50% Human Human -DTXSID7042273 Css NA 3.639 mg/L PBTK NA 95% Human Human -DTXSID7042273 Clint NA 23.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042273 Fup NA 0.0619 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042273 Vd NA 2.029 L/kg 1compartment NA NA Rat Human -DTXSID7042273 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042273 TK.Half.Life NA 4.188 hours 1compartment NA NA Rat Human -DTXSID7042273 Css NA 0.4837 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042273 Css NA 2.485 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042273 Css NA 0.3144 mg/L PBTK NA 50% Rat Human -DTXSID7042273 Css NA 1.581 mg/L PBTK NA 95% Rat Human -DTXSID7042279 Clint NA 50.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042279 Fup NA 0.128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042279 Vd NA 2.272 L/kg 1compartment NA NA Human Human +DTXSID7042198 TK.Half.Life NA 0.9647 hours 1compartment NA NA Rat Human +DTXSID7042198 Css NA 0.01419 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042198 Css NA 0.07467 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042198 Css NA 0.01014 mg/L PBTK NA 50% Rat Human +DTXSID7042198 Css NA 0.05052 mg/L PBTK NA 95% Rat Human +DTXSID7042273 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042273 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042273 Vd NA 2.223 L/kg 1compartment NA NA Human Human +DTXSID7042273 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7042273 TK.Half.Life NA 21.29 hours 1compartment NA NA Human Human +DTXSID7042273 Css NA 1.357 mg/L 3compartmentss NA 50% Human Human +DTXSID7042273 Css NA 10.74 mg/L 3compartmentss NA 95% Human Human +DTXSID7042273 Css NA 0.8848 mg/L PBTK NA 50% Human Human +DTXSID7042273 Css NA 6.72 mg/L PBTK NA 95% Human Human +DTXSID7042273 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042273 Fup 0.0248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042273 Vd NA 1.657 L/kg 1compartment NA NA Rat Human +DTXSID7042273 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7042273 TK.Half.Life NA 6.194 hours 1compartment NA NA Rat Human +DTXSID7042273 Css NA 0.1757 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042273 Css NA 1.114 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042273 Css NA 0.1122 mg/L PBTK NA 50% Rat Human +DTXSID7042273 Css NA 0.6911 mg/L PBTK NA 95% Rat Human +DTXSID7042279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042279 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042279 Vd NA 2.41 L/kg 1compartment NA NA Human Human DTXSID7042279 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7042279 TK.Half.Life NA 4.158 hours 1compartment NA NA Human Human -DTXSID7042279 Css NA 0.1478 mg/L 3compartmentss NA 50% Human Human -DTXSID7042279 Css NA 1.079 mg/L 3compartmentss NA 95% Human Human -DTXSID7042279 Css NA 0.1024 mg/L PBTK NA 50% Human Human -DTXSID7042279 Css NA 0.7014 mg/L PBTK NA 95% Human Human -DTXSID7042279 Clint NA 50.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042279 Fup NA 0.128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042279 Vd NA 1.722 L/kg 1compartment NA NA Rat Human +DTXSID7042279 TK.Half.Life NA 7.625 hours 1compartment NA NA Human Human +DTXSID7042279 Css NA 0.311 mg/L 3compartmentss NA 50% Human Human +DTXSID7042279 Css NA 2.101 mg/L 3compartmentss NA 95% Human Human +DTXSID7042279 Css NA 0.2186 mg/L PBTK NA 50% Human Human +DTXSID7042279 Css NA 1.414 mg/L PBTK NA 95% Human Human +DTXSID7042279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042279 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042279 Vd NA 1.827 L/kg 1compartment NA NA Rat Human DTXSID7042279 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042279 TK.Half.Life NA 1.287 hours 1compartment NA NA Rat Human -DTXSID7042279 Css NA 0.08161 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042279 Css NA 0.4627 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042279 Css NA 0.05392 mg/L PBTK NA 50% Rat Human -DTXSID7042279 Css NA 0.2947 mg/L PBTK NA 95% Rat Human -DTXSID7042352 Clint NA 652.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042352 Fup NA 0.0218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042352 Vd NA 2.013 L/kg 1compartment NA NA Human Human -DTXSID7042352 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7042352 TK.Half.Life NA 2.351 hours 1compartment NA NA Human Human -DTXSID7042352 Css NA 0.0497 mg/L 3compartmentss NA 50% Human Human -DTXSID7042352 Css NA 0.4236 mg/L 3compartmentss NA 95% Human Human -DTXSID7042352 Css NA 0.03214 mg/L PBTK NA 50% Human Human -DTXSID7042352 Css NA 0.2645 mg/L PBTK NA 95% Human Human -DTXSID7042352 Clint NA 652.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042352 Fup NA 0.0218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042352 Vd NA 1.501 L/kg 1compartment NA NA Rat Human +DTXSID7042279 TK.Half.Life NA 2.157 hours 1compartment NA NA Rat Human +DTXSID7042279 Css NA 0.04007 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042279 Css NA 0.211 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042279 Css NA 0.02792 mg/L PBTK NA 50% Rat Human +DTXSID7042279 Css NA 0.1408 mg/L PBTK NA 95% Rat Human +DTXSID7042352 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042352 Fup 0.0461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042352 Vd NA 2.465 L/kg 1compartment NA NA Human Human +DTXSID7042352 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7042352 TK.Half.Life NA 17.82 hours 1compartment NA NA Human Human +DTXSID7042352 Css NA 0.922 mg/L 3compartmentss NA 50% Human Human +DTXSID7042352 Css NA 6.122 mg/L 3compartmentss NA 95% Human Human +DTXSID7042352 Css NA 0.6138 mg/L PBTK NA 50% Human Human +DTXSID7042352 Css NA 3.951 mg/L PBTK NA 95% Human Human +DTXSID7042352 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042352 Fup 0.0461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042352 Vd NA 1.852 L/kg 1compartment NA NA Rat Human DTXSID7042352 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042352 TK.Half.Life NA 0.7684 hours 1compartment NA NA Rat Human -DTXSID7042352 Css NA 0.02753 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042352 Css NA 0.2076 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042352 Css NA 0.01679 mg/L PBTK NA 50% Rat Human -DTXSID7042352 Css NA 0.1222 mg/L PBTK NA 95% Rat Human -DTXSID7042437 Clint NA 41.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042437 Fup NA 0.0679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042437 Vd NA 2.08 L/kg 1compartment NA NA Human Human +DTXSID7042352 TK.Half.Life NA 4.661 hours 1compartment NA NA Rat Human +DTXSID7042352 Css NA 0.1184 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042352 Css NA 0.6347 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042352 Css NA 0.07842 mg/L PBTK NA 50% Rat Human +DTXSID7042352 Css NA 0.4127 mg/L PBTK NA 95% Rat Human +DTXSID7042437 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042437 Fup 0.062 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042437 Vd NA 2.005 L/kg 1compartment NA NA Human Human DTXSID7042437 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7042437 TK.Half.Life NA 5.757 hours 1compartment NA NA Human Human -DTXSID7042437 Css NA 0.2962 mg/L 3compartmentss NA 50% Human Human -DTXSID7042437 Css NA 2.101 mg/L 3compartmentss NA 95% Human Human -DTXSID7042437 Css NA 0.1978 mg/L PBTK NA 50% Human Human -DTXSID7042437 Css NA 1.348 mg/L PBTK NA 95% Human Human -DTXSID7042437 Clint NA 41.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042437 Fup NA 0.0679 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042437 Vd NA 1.564 L/kg 1compartment NA NA Rat Human +DTXSID7042437 TK.Half.Life NA 9.359 hours 1compartment NA NA Human Human +DTXSID7042437 Css NA 0.5984 mg/L 3compartmentss NA 50% Human Human +DTXSID7042437 Css NA 4.466 mg/L 3compartmentss NA 95% Human Human +DTXSID7042437 Css NA 0.3929 mg/L PBTK NA 50% Human Human +DTXSID7042437 Css NA 2.789 mg/L PBTK NA 95% Human Human +DTXSID7042437 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042437 Fup 0.062 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042437 Vd NA 1.507 L/kg 1compartment NA NA Rat Human DTXSID7042437 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042437 TK.Half.Life NA 1.851 hours 1compartment NA NA Rat Human -DTXSID7042437 Css NA 0.1674 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042437 Css NA 0.9339 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042437 Css NA 0.1056 mg/L PBTK NA 50% Rat Human -DTXSID7042437 Css NA 0.5691 mg/L PBTK NA 95% Rat Human +DTXSID7042437 TK.Half.Life NA 3.062 hours 1compartment NA NA Rat Human +DTXSID7042437 Css NA 0.07726 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042437 Css NA 0.4484 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042437 Css NA 0.05001 mg/L PBTK NA 50% Rat Human +DTXSID7042437 Css NA 0.2787 mg/L PBTK NA 95% Rat Human +DTXSID7042481 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042481 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7042481 Vd NA 0.8019 L/kg 1compartment NA NA Human Human +DTXSID7042481 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7042481 TK.Half.Life NA 1.044 hours 1compartment NA NA Human Human +DTXSID7042481 Css NA 0.09544 mg/L 3compartmentss NA 50% Human Human +DTXSID7042481 Css NA 0.818 mg/L 3compartmentss NA 95% Human Human +DTXSID7042481 Css NA 0.07778 mg/L PBTK NA 50% Human Human +DTXSID7042481 Css NA 0.5611 mg/L PBTK NA 95% Human Human +DTXSID7042481 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042481 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7042481 Vd NA 0.806 L/kg 1compartment NA NA Rat Human +DTXSID7042481 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7042481 TK.Half.Life NA 0.5572 hours 1compartment NA NA Rat Human +DTXSID7042481 Css NA 0.01044 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042481 Css NA 0.07998 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042481 Css NA 0.008685 mg/L PBTK NA 50% Rat Human +DTXSID7042481 Css NA 0.05035 mg/L PBTK NA 95% Rat Human DTXSID7042514 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7042514 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7042514 Vd NA 0.8126 L/kg 1compartment NA NA Human Human +DTXSID7042514 Vd NA 0.8053 L/kg 1compartment NA NA Human Human DTXSID7042514 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7042514 TK.Half.Life NA 5.259 hours 1compartment NA NA Human Human -DTXSID7042514 Css NA 0.8284 mg/L 3compartmentss NA 50% Human Human -DTXSID7042514 Css NA 5.553 mg/L 3compartmentss NA 95% Human Human -DTXSID7042514 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID7042514 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID7042514 TK.Half.Life NA 5.212 hours 1compartment NA NA Human Human +DTXSID7042514 Css NA 0.6996 mg/L 3compartmentss NA 50% Human Human +DTXSID7042514 Css NA 5.039 mg/L 3compartmentss NA 95% Human Human +DTXSID7042514 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID7042514 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID7042514 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7042514 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7042514 Vd NA 0.8621 L/kg 1compartment NA NA Rat Human +DTXSID7042514 Vd NA 0.8564 L/kg 1compartment NA NA Rat Human DTXSID7042514 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7042514 TK.Half.Life NA 1.901 hours 1compartment NA NA Rat Human -DTXSID7042514 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human -DTXSID7042514 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID7042514 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID7042514 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID7043829 Clint NA 168.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043829 Fup NA 0.6151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043829 Vd NA 1.22 L/kg 1compartment NA NA Human Human -DTXSID7043829 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7043829 TK.Half.Life NA 0.7801 hours 1compartment NA NA Human Human -DTXSID7043829 Css NA 0.004598 mg/L 3compartmentss NA 50% Human Human -DTXSID7043829 Css NA 0.05109 mg/L 3compartmentss NA 95% Human Human -DTXSID7043829 Css NA 0.003929 mg/L PBTK NA 50% Human Human -DTXSID7043829 Css NA 0.0363 mg/L PBTK NA 95% Human Human -DTXSID7043829 Clint NA 168.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043829 Fup NA 0.6151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043829 Vd NA 1.104 L/kg 1compartment NA NA Rat Human +DTXSID7042514 TK.Half.Life NA 1.888 hours 1compartment NA NA Rat Human +DTXSID7042514 Css NA 0.01282 mg/L 3compartmentss NA 50% Rat Human +DTXSID7042514 Css NA 0.09947 mg/L 3compartmentss NA 95% Rat Human +DTXSID7042514 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID7042514 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID70426091 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70426091 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70426091 Vd NA 1.13 L/kg 1compartment NA NA Human Human +DTXSID70426091 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70426091 TK.Half.Life NA 2.767 hours 1compartment NA NA Human Human +DTXSID70426091 Css NA 0.1962 mg/L 3compartmentss NA 50% Human Human +DTXSID70426091 Css NA 1.257 mg/L 3compartmentss NA 95% Human Human +DTXSID70426091 Css NA 0.1481 mg/L PBTK NA 50% Human Human +DTXSID70426091 Css NA 0.855 mg/L PBTK NA 95% Human Human +DTXSID70426091 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70426091 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70426091 Vd NA 0.9559 L/kg 1compartment NA NA Rat Human +DTXSID70426091 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70426091 TK.Half.Life NA 1.253 hours 1compartment NA NA Rat Human +DTXSID70426091 Css NA 0.0163 mg/L 3compartmentss NA 50% Rat Human +DTXSID70426091 Css NA 0.09075 mg/L 3compartmentss NA 95% Rat Human +DTXSID70426091 Css NA 0.01244 mg/L PBTK NA 50% Rat Human +DTXSID70426091 Css NA 0.05881 mg/L PBTK NA 95% Rat Human +DTXSID70436993 Clint 1 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70436993 Fup 0.396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70436993 Vd NA 0.706 L/kg 1compartment NA NA Human Human +DTXSID70436993 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70436993 TK.Half.Life NA 4.587 hours 1compartment NA NA Human Human +DTXSID70436993 Css NA 0.6729 mg/L 3compartmentss NA 50% Human Human +DTXSID70436993 Css NA 3.294 mg/L 3compartmentss NA 95% Human Human +DTXSID70436993 Css NA 0.5102 mg/L PBTK NA 50% Human Human +DTXSID70436993 Css NA 2.145 mg/L PBTK NA 95% Human Human +DTXSID70436993 Clint 1 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70436993 Fup 0.396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70436993 Vd NA 0.6737 L/kg 1compartment NA NA Rat Human +DTXSID70436993 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70436993 TK.Half.Life NA 2.12 hours 1compartment NA NA Rat Human +DTXSID70436993 Css NA 0.06158 mg/L 3compartmentss NA 50% Rat Human +DTXSID70436993 Css NA 0.2522 mg/L 3compartmentss NA 95% Rat Human +DTXSID70436993 Css NA 0.04613 mg/L PBTK NA 50% Rat Human +DTXSID70436993 Css NA 0.1568 mg/L PBTK NA 95% Rat Human +DTXSID7043829 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7043829 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7043829 Vd NA 1.031 L/kg 1compartment NA NA Human Human +DTXSID7043829 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7043829 TK.Half.Life NA 17.57 hours 1compartment NA NA Human Human +DTXSID7043829 Css NA 1.75 mg/L 3compartmentss NA 50% Human Human +DTXSID7043829 Css NA 7.567 mg/L 3compartmentss NA 95% Human Human +DTXSID7043829 Css NA 1.379 mg/L PBTK NA 50% Human Human +DTXSID7043829 Css NA 4.909 mg/L PBTK NA 95% Human Human +DTXSID7043829 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7043829 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7043829 Vd NA 0.9158 L/kg 1compartment NA NA Rat Human DTXSID7043829 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7043829 TK.Half.Life NA 0.3117 hours 1compartment NA NA Rat Human -DTXSID7043829 Css NA 0.002386 mg/L 3compartmentss NA 50% Rat Human -DTXSID7043829 Css NA 0.0253 mg/L 3compartmentss NA 95% Rat Human -DTXSID7043829 Css NA 0.002009 mg/L PBTK NA 50% Rat Human -DTXSID7043829 Css NA 0.01718 mg/L PBTK NA 95% Rat Human -DTXSID7043873 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043873 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043873 Vd NA 1.938 L/kg 1compartment NA NA Human Human -DTXSID7043873 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7043873 TK.Half.Life NA 1.232 hours 1compartment NA NA Human Human -DTXSID7043873 Css NA 0.02503 mg/L 3compartmentss NA 50% Human Human -DTXSID7043873 Css NA 0.3122 mg/L 3compartmentss NA 95% Human Human -DTXSID7043873 Css NA 0.02542 mg/L PBTK NA 50% Human Human -DTXSID7043873 Css NA 0.27 mg/L PBTK NA 95% Human Human -DTXSID7043873 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043873 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043873 Vd NA 1.974 L/kg 1compartment NA NA Rat Human +DTXSID7043829 TK.Half.Life NA 5.045 hours 1compartment NA NA Rat Human +DTXSID7043829 Css NA 0.1109 mg/L 3compartmentss NA 50% Rat Human +DTXSID7043829 Css NA 0.4167 mg/L 3compartmentss NA 95% Rat Human +DTXSID7043829 Css NA 0.0868 mg/L PBTK NA 50% Rat Human +DTXSID7043829 Css NA 0.2638 mg/L PBTK NA 95% Rat Human +DTXSID7043873 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7043873 Fup 0.748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7043873 Vd NA 1.592 L/kg 1compartment NA NA Human Human +DTXSID7043873 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7043873 TK.Half.Life NA 13.77 hours 1compartment NA NA Human Human +DTXSID7043873 Css NA 0.8602 mg/L 3compartmentss NA 50% Human Human +DTXSID7043873 Css NA 5.866 mg/L 3compartmentss NA 95% Human Human +DTXSID7043873 Css NA 0.8222 mg/L PBTK NA 50% Human Human +DTXSID7043873 Css NA 4.008 mg/L PBTK NA 95% Human Human +DTXSID7043873 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7043873 Fup 0.748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7043873 Vd NA 1.618 L/kg 1compartment NA NA Rat Human DTXSID7043873 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7043873 TK.Half.Life NA 0.6261 hours 1compartment NA NA Rat Human -DTXSID7043873 Css NA 0.01232 mg/L 3compartmentss NA 50% Rat Human -DTXSID7043873 Css NA 0.1226 mg/L 3compartmentss NA 95% Rat Human -DTXSID7043873 Css NA 0.0126 mg/L PBTK NA 50% Rat Human -DTXSID7043873 Css NA 0.09553 mg/L PBTK NA 95% Rat Human -DTXSID7043902 Clint NA 150.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043902 Fup NA 0.025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043902 Vd NA 2.381 L/kg 1compartment NA NA Human Human -DTXSID7043902 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7043902 TK.Half.Life NA 5.291 hours 1compartment NA NA Human Human -DTXSID7043902 Css NA 0.2156 mg/L 3compartmentss NA 50% Human Human -DTXSID7043902 Css NA 1.644 mg/L 3compartmentss NA 95% Human Human -DTXSID7043902 Css NA 0.1422 mg/L PBTK NA 50% Human Human -DTXSID7043902 Css NA 1.028 mg/L PBTK NA 95% Human Human -DTXSID7043902 Clint NA 150.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043902 Fup NA 0.025 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043902 Vd NA 1.776 L/kg 1compartment NA NA Rat Human -DTXSID7043902 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7043902 TK.Half.Life NA 1.526 hours 1compartment NA NA Rat Human -DTXSID7043902 Css NA 0.1212 mg/L 3compartmentss NA 50% Rat Human -DTXSID7043902 Css NA 0.765 mg/L 3compartmentss NA 95% Rat Human -DTXSID7043902 Css NA 0.07558 mg/L PBTK NA 50% Rat Human -DTXSID7043902 Css NA 0.4678 mg/L PBTK NA 95% Rat Human -DTXSID7043908 Clint NA 169.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043908 Fup NA 0.3654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043908 Vd NA 1.396 L/kg 1compartment NA NA Human Human +DTXSID7043873 TK.Half.Life NA 4.767 hours 1compartment NA NA Rat Human +DTXSID7043873 Css NA 0.04978 mg/L 3compartmentss NA 50% Rat Human +DTXSID7043873 Css NA 0.3541 mg/L 3compartmentss NA 95% Rat Human +DTXSID7043873 Css NA 0.04882 mg/L PBTK NA 50% Rat Human +DTXSID7043873 Css NA 0.2299 mg/L PBTK NA 95% Rat Human +DTXSID7043908 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7043908 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7043908 Vd NA 1.418 L/kg 1compartment NA NA Human Human DTXSID7043908 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7043908 TK.Half.Life NA 1.061 hours 1compartment NA NA Human Human -DTXSID7043908 Css NA 0.00823 mg/L 3compartmentss NA 50% Human Human -DTXSID7043908 Css NA 0.06682 mg/L 3compartmentss NA 95% Human Human -DTXSID7043908 Css NA 0.006357 mg/L PBTK NA 50% Human Human -DTXSID7043908 Css NA 0.04689 mg/L PBTK NA 95% Human Human -DTXSID7043908 Clint NA 169.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043908 Fup NA 0.3654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043908 Vd NA 1.159 L/kg 1compartment NA NA Rat Human +DTXSID7043908 TK.Half.Life NA 2.844 hours 1compartment NA NA Human Human +DTXSID7043908 Css NA 0.1602 mg/L 3compartmentss NA 50% Human Human +DTXSID7043908 Css NA 1.136 mg/L 3compartmentss NA 95% Human Human +DTXSID7043908 Css NA 0.1108 mg/L PBTK NA 50% Human Human +DTXSID7043908 Css NA 0.7447 mg/L PBTK NA 95% Human Human +DTXSID7043908 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7043908 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7043908 Vd NA 1.112 L/kg 1compartment NA NA Rat Human DTXSID7043908 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7043908 TK.Half.Life NA 0.3929 hours 1compartment NA NA Rat Human -DTXSID7043908 Css NA 0.004448 mg/L 3compartmentss NA 50% Rat Human -DTXSID7043908 Css NA 0.02971 mg/L 3compartmentss NA 95% Rat Human -DTXSID7043908 Css NA 0.003358 mg/L PBTK NA 50% Rat Human -DTXSID7043908 Css NA 0.02072 mg/L PBTK NA 95% Rat Human +DTXSID7043908 TK.Half.Life NA 1.132 hours 1compartment NA NA Rat Human +DTXSID7043908 Css NA 0.02074 mg/L 3compartmentss NA 50% Rat Human +DTXSID7043908 Css NA 0.113 mg/L 3compartmentss NA 95% Rat Human +DTXSID7043908 Css NA 0.01422 mg/L PBTK NA 50% Rat Human +DTXSID7043908 Css NA 0.07341 mg/L PBTK NA 95% Rat Human DTXSID7043950 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7043950 Fup NA 0.3821 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043950 Vd NA 0.3282 L/kg 1compartment NA NA Human Human +DTXSID7043950 Vd NA 0.3576 L/kg 1compartment NA NA Human Human DTXSID7043950 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7043950 TK.Half.Life NA 5.559 hours 1compartment NA NA Human Human -DTXSID7043950 Css NA 2.088 mg/L 3compartmentss NA 50% Human Human -DTXSID7043950 Css NA 8.509 mg/L 3compartmentss NA 95% Human Human -DTXSID7043950 Css NA 1.403 mg/L PBTK NA 50% Human Human -DTXSID7043950 Css NA 5.214 mg/L PBTK NA 95% Human Human +DTXSID7043950 TK.Half.Life NA 6.054 hours 1compartment NA NA Human Human +DTXSID7043950 Css NA 1.743 mg/L 3compartmentss NA 50% Human Human +DTXSID7043950 Css NA 7.243 mg/L 3compartmentss NA 95% Human Human +DTXSID7043950 Css NA 1.191 mg/L PBTK NA 50% Human Human +DTXSID7043950 Css NA 4.502 mg/L PBTK NA 95% Human Human DTXSID7043950 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7043950 Fup NA 0.3821 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043950 Vd NA 0.3391 L/kg 1compartment NA NA Rat Human +DTXSID7043950 Vd NA 0.3652 L/kg 1compartment NA NA Rat Human DTXSID7043950 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7043950 TK.Half.Life NA 1.957 hours 1compartment NA NA Rat Human -DTXSID7043950 Css NA 0.5752 mg/L 3compartmentss NA 50% Rat Human -DTXSID7043950 Css NA 1.997 mg/L 3compartmentss NA 95% Rat Human -DTXSID7043950 Css NA 0.3657 mg/L PBTK NA 50% Rat Human -DTXSID7043950 Css NA 1.14 mg/L PBTK NA 95% Rat Human -DTXSID7043952 Clint NA 9.001 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043952 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7043952 Vd NA 2.102 L/kg 1compartment NA NA Human Human -DTXSID7043952 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID7043952 TK.Half.Life NA 52.79 hours 1compartment NA NA Human Human -DTXSID7043952 Css NA 3.963 mg/L 3compartmentss NA 50% Human Human -DTXSID7043952 Css NA 30.46 mg/L 3compartmentss NA 95% Human Human -DTXSID7043952 Css NA 2.558 mg/L PBTK NA 50% Human Human -DTXSID7043952 Css NA 18.73 mg/L PBTK NA 95% Human Human -DTXSID7043952 Clint NA 9.001 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043952 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7043952 Vd NA 1.563 L/kg 1compartment NA NA Rat Human -DTXSID7043952 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID7043952 TK.Half.Life NA 15.88 hours 1compartment NA NA Rat Human -DTXSID7043952 Css NA 2.14 mg/L 3compartmentss NA 50% Rat Human -DTXSID7043952 Css NA 12.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID7043952 Css NA 1.3 mg/L PBTK NA 50% Rat Human -DTXSID7043952 Css NA 7.416 mg/L PBTK NA 95% Rat Human -DTXSID7044130 Clint NA 4.836 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7043950 TK.Half.Life NA 2.107 hours 1compartment NA NA Rat Human +DTXSID7043950 Css NA 0.03132 mg/L 3compartmentss NA 50% Rat Human +DTXSID7043950 Css NA 0.1954 mg/L 3compartmentss NA 95% Rat Human +DTXSID7043950 Css NA 0.02043 mg/L PBTK NA 50% Rat Human +DTXSID7043950 Css NA 0.1189 mg/L PBTK NA 95% Rat Human +DTXSID7043952 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7043952 Fup 0.0056 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7043952 Vd NA 1.31 L/kg 1compartment NA NA Human Human +DTXSID7043952 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7043952 TK.Half.Life NA 29.04 hours 1compartment NA NA Human Human +DTXSID7043952 Css NA 3.74 mg/L 3compartmentss NA 50% Human Human +DTXSID7043952 Css NA 34.53 mg/L 3compartmentss NA 95% Human Human +DTXSID7043952 Css NA 2.298 mg/L PBTK NA 50% Human Human +DTXSID7043952 Css NA 20.68 mg/L PBTK NA 95% Human Human +DTXSID7043952 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7043952 Fup 0.0056 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7043952 Vd NA 0.9616 L/kg 1compartment NA NA Rat Human +DTXSID7043952 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7043952 TK.Half.Life NA 11.83 hours 1compartment NA NA Rat Human +DTXSID7043952 Css NA 0.4898 mg/L 3compartmentss NA 50% Rat Human +DTXSID7043952 Css NA 3.78 mg/L 3compartmentss NA 95% Rat Human +DTXSID7043952 Css NA 0.2892 mg/L PBTK NA 50% Rat Human +DTXSID7043952 Css NA 2.165 mg/L PBTK NA 95% Rat Human +DTXSID7044130 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7044130 Fup 0.44 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID7044130 Vd NA 0.4249 L/kg 1compartment NA NA Human Human DTXSID7044130 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044130 TK.Half.Life NA 0.9532 hours 1compartment NA NA Human Human -DTXSID7044130 Css NA 0.2052 mg/L 3compartmentss NA 50% Human Human -DTXSID7044130 Css NA 1.28 mg/L 3compartmentss NA 95% Human Human -DTXSID7044130 Css NA 0.1442 mg/L PBTK NA 50% Human Human -DTXSID7044130 Css NA 0.8208 mg/L PBTK NA 95% Human Human -DTXSID7044130 Clint NA 4.836 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7044130 TK.Half.Life NA 0.8229 hours 1compartment NA NA Human Human +DTXSID7044130 Css NA 0.1587 mg/L 3compartmentss NA 50% Human Human +DTXSID7044130 Css NA 1.072 mg/L 3compartmentss NA 95% Human Human +DTXSID7044130 Css NA 0.1107 mg/L PBTK NA 50% Human Human +DTXSID7044130 Css NA 0.6869 mg/L PBTK NA 95% Human Human +DTXSID7044130 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7044130 Fup 0.44 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID7044130 Vd NA 0.4339 L/kg 1compartment NA NA Rat Human DTXSID7044130 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044130 TK.Half.Life NA 0.5373 hours 1compartment NA NA Rat Human -DTXSID7044130 Css NA 0.1007 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044130 Css NA 0.5043 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044130 Css NA 0.06716 mg/L PBTK NA 50% Rat Human -DTXSID7044130 Css NA 0.3003 mg/L PBTK NA 95% Rat Human -DTXSID7044132 Clint NA 14.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044132 Fup NA 0.4173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044132 Vd NA 0.5337 L/kg 1compartment NA NA Human Human +DTXSID7044130 TK.Half.Life NA 0.4621 hours 1compartment NA NA Rat Human +DTXSID7044130 Css NA 0.01827 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044130 Css NA 0.09358 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044130 Css NA 0.01266 mg/L PBTK NA 50% Rat Human +DTXSID7044130 Css NA 0.05775 mg/L PBTK NA 95% Rat Human +DTXSID7044132 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044132 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044132 Vd NA 0.5455 L/kg 1compartment NA NA Human Human DTXSID7044132 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044132 TK.Half.Life NA 0.6883 hours 1compartment NA NA Human Human -DTXSID7044132 Css NA 0.07294 mg/L 3compartmentss NA 50% Human Human -DTXSID7044132 Css NA 0.5558 mg/L 3compartmentss NA 95% Human Human -DTXSID7044132 Css NA 0.05339 mg/L PBTK NA 50% Human Human -DTXSID7044132 Css NA 0.3726 mg/L PBTK NA 95% Human Human -DTXSID7044132 Clint NA 14.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044132 Fup NA 0.4173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044132 Vd NA 0.5429 L/kg 1compartment NA NA Rat Human +DTXSID7044132 TK.Half.Life NA 0.9249 hours 1compartment NA NA Human Human +DTXSID7044132 Css NA 0.1253 mg/L 3compartmentss NA 50% Human Human +DTXSID7044132 Css NA 0.9698 mg/L 3compartmentss NA 95% Human Human +DTXSID7044132 Css NA 0.0934 mg/L PBTK NA 50% Human Human +DTXSID7044132 Css NA 0.6344 mg/L PBTK NA 95% Human Human +DTXSID7044132 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044132 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044132 Vd NA 0.5644 L/kg 1compartment NA NA Rat Human DTXSID7044132 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044132 TK.Half.Life NA 0.3705 hours 1compartment NA NA Rat Human -DTXSID7044132 Css NA 0.03935 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044132 Css NA 0.223 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044132 Css NA 0.02746 mg/L PBTK NA 50% Rat Human -DTXSID7044132 Css NA 0.1395 mg/L PBTK NA 95% Rat Human -DTXSID7044215 Clint NA 25.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044215 Fup NA 0.0706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044215 Vd NA 0.4195 L/kg 1compartment NA NA Human Human +DTXSID7044132 TK.Half.Life NA 0.5247 hours 1compartment NA NA Rat Human +DTXSID7044132 Css NA 0.01478 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044132 Css NA 0.08515 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044132 Css NA 0.01105 mg/L PBTK NA 50% Rat Human +DTXSID7044132 Css NA 0.05406 mg/L PBTK NA 95% Rat Human +DTXSID7044215 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044215 Fup 0.0462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044215 Vd NA 0.3585 L/kg 1compartment NA NA Human Human DTXSID7044215 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044215 TK.Half.Life NA 1.236 hours 1compartment NA NA Human Human -DTXSID7044215 Css NA 0.3593 mg/L 3compartmentss NA 50% Human Human -DTXSID7044215 Css NA 2.649 mg/L 3compartmentss NA 95% Human Human -DTXSID7044215 Css NA 0.2196 mg/L PBTK NA 50% Human Human -DTXSID7044215 Css NA 1.575 mg/L PBTK NA 95% Human Human -DTXSID7044215 Clint NA 25.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044215 Fup NA 0.0706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044215 Vd NA 0.3672 L/kg 1compartment NA NA Rat Human +DTXSID7044215 TK.Half.Life NA 4.603 hours 1compartment NA NA Human Human +DTXSID7044215 Css NA 2.148 mg/L 3compartmentss NA 50% Human Human +DTXSID7044215 Css NA 14.17 mg/L 3compartmentss NA 95% Human Human +DTXSID7044215 Css NA 1.284 mg/L PBTK NA 50% Human Human +DTXSID7044215 Css NA 8.296 mg/L PBTK NA 95% Human Human +DTXSID7044215 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044215 Fup 0.0462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044215 Vd NA 0.3134 L/kg 1compartment NA NA Rat Human DTXSID7044215 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044215 TK.Half.Life NA 0.6502 hours 1compartment NA NA Rat Human -DTXSID7044215 Css NA 0.2022 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044215 Css NA 1.159 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044215 Css NA 0.116 mg/L PBTK NA 50% Rat Human -DTXSID7044215 Css NA 0.652 mg/L PBTK NA 95% Rat Human -DTXSID7044217 Clint NA 0.9923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044217 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044217 Vd NA 0.2427 L/kg 1compartment NA NA Human Human -DTXSID7044217 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID7044217 TK.Half.Life NA 44.58 hours 1compartment NA NA Human Human -DTXSID7044217 Css NA 32.19 mg/L 3compartmentss NA 50% Human Human -DTXSID7044217 Css NA 213.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7044217 Css NA 19.18 mg/L PBTK NA 50% Human Human -DTXSID7044217 Css NA 124.6 mg/L PBTK NA 95% Human Human -DTXSID7044217 Clint NA 0.9923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044217 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044217 Vd NA 0.2348 L/kg 1compartment NA NA Rat Human -DTXSID7044217 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID7044217 TK.Half.Life NA 21.6 hours 1compartment NA NA Rat Human -DTXSID7044217 Css NA 13.46 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044217 Css NA 78.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044217 Css NA 7.472 mg/L PBTK NA 50% Rat Human -DTXSID7044217 Css NA 42.51 mg/L PBTK NA 95% Rat Human -DTXSID7044267 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044267 Fup NA 0.0791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044267 Vd NA 1.317 L/kg 1compartment NA NA Human Human -DTXSID7044267 Days.Css NA 25 Days PBTK NA NA Human Human -DTXSID7044267 TK.Half.Life NA 125 hours 1compartment NA NA Human Human -DTXSID7044267 Css NA 13.9 mg/L 3compartmentss NA 50% Human Human -DTXSID7044267 Css NA 60.16 mg/L 3compartmentss NA 95% Human Human -DTXSID7044267 Css NA 9.263 mg/L PBTK NA 50% Human Human -DTXSID7044267 Css NA 36.31 mg/L PBTK NA 95% Human Human -DTXSID7044267 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044267 Fup NA 0.0791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044267 Vd NA 1.108 L/kg 1compartment NA NA Rat Human -DTXSID7044267 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID7044267 TK.Half.Life NA 32.06 hours 1compartment NA NA Rat Human -DTXSID7044267 Css NA 3.843 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044267 Css NA 14.55 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044267 Css NA 2.415 mg/L PBTK NA 50% Rat Human -DTXSID7044267 Css NA 8.232 mg/L PBTK NA 95% Rat Human -DTXSID7044340 Clint NA 7.489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044340 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044340 Vd NA 0.1896 L/kg 1compartment NA NA Human Human -DTXSID7044340 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044340 TK.Half.Life NA 3.855 hours 1compartment NA NA Human Human -DTXSID7044340 Css NA 3.704 mg/L 3compartmentss NA 50% Human Human -DTXSID7044340 Css NA 30.22 mg/L 3compartmentss NA 95% Human Human -DTXSID7044340 Css NA 2.177 mg/L PBTK NA 50% Human Human -DTXSID7044340 Css NA 17.58 mg/L PBTK NA 95% Human Human -DTXSID7044340 Clint NA 7.489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044340 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044340 Vd NA 0.1873 L/kg 1compartment NA NA Rat Human -DTXSID7044340 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044340 TK.Half.Life NA 2.436 hours 1compartment NA NA Rat Human -DTXSID7044340 Css NA 1.994 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044340 Css NA 13.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044340 Css NA 1.093 mg/L PBTK NA 50% Rat Human -DTXSID7044340 Css NA 7.444 mg/L PBTK NA 95% Rat Human -DTXSID7044342 Clint NA 88.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044342 Fup NA 0.0636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044342 Vd NA 2.389 L/kg 1compartment NA NA Human Human +DTXSID7044215 TK.Half.Life NA 2.504 hours 1compartment NA NA Rat Human +DTXSID7044215 Css NA 0.2649 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044215 Css NA 1.326 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044215 Css NA 0.1538 mg/L PBTK NA 50% Rat Human +DTXSID7044215 Css NA 0.7539 mg/L PBTK NA 95% Rat Human +DTXSID7044217 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044217 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044217 Vd NA 0.3201 L/kg 1compartment NA NA Human Human +DTXSID7044217 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7044217 TK.Half.Life NA 1.527 hours 1compartment NA NA Human Human +DTXSID7044217 Css NA 0.3326 mg/L 3compartmentss NA 50% Human Human +DTXSID7044217 Css NA 2.444 mg/L 3compartmentss NA 95% Human Human +DTXSID7044217 Css NA 0.2104 mg/L PBTK NA 50% Human Human +DTXSID7044217 Css NA 1.467 mg/L PBTK NA 95% Human Human +DTXSID7044217 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044217 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044217 Vd NA 0.3239 L/kg 1compartment NA NA Rat Human +DTXSID7044217 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7044217 TK.Half.Life NA 0.9297 hours 1compartment NA NA Rat Human +DTXSID7044217 Css NA 0.003396 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044217 Css NA 0.02162 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044217 Css NA 0.002013 mg/L PBTK NA 50% Rat Human +DTXSID7044217 Css NA 0.01229 mg/L PBTK NA 95% Rat Human +DTXSID7044267 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044267 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044267 Vd NA 1.966 L/kg 1compartment NA NA Human Human +DTXSID7044267 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7044267 TK.Half.Life NA 4.677 hours 1compartment NA NA Human Human +DTXSID7044267 Css NA 0.1938 mg/L 3compartmentss NA 50% Human Human +DTXSID7044267 Css NA 1.581 mg/L 3compartmentss NA 95% Human Human +DTXSID7044267 Css NA 0.1398 mg/L PBTK NA 50% Human Human +DTXSID7044267 Css NA 1.035 mg/L PBTK NA 95% Human Human +DTXSID7044267 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044267 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044267 Vd NA 1.633 L/kg 1compartment NA NA Rat Human +DTXSID7044267 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7044267 TK.Half.Life NA 1.924 hours 1compartment NA NA Rat Human +DTXSID7044267 Css NA 0.00938 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044267 Css NA 0.08077 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044267 Css NA 0.006719 mg/L PBTK NA 50% Rat Human +DTXSID7044267 Css NA 0.052 mg/L PBTK NA 95% Rat Human +DTXSID7044340 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044340 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044340 Vd NA 10.58 L/kg 1compartment NA NA Human Human +DTXSID7044340 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7044340 TK.Half.Life NA 44.07 hours 1compartment NA NA Human Human +DTXSID7044340 Css NA 0.2722 mg/L 3compartmentss NA 50% Human Human +DTXSID7044340 Css NA 2.112 mg/L 3compartmentss NA 95% Human Human +DTXSID7044340 Css NA 0.371 mg/L PBTK NA 50% Human Human +DTXSID7044340 Css NA 2.288 mg/L PBTK NA 95% Human Human +DTXSID7044340 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044340 Fup 0.0719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044340 Vd NA 8.386 L/kg 1compartment NA NA Rat Human +DTXSID7044340 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7044340 TK.Half.Life NA 13.91 hours 1compartment NA NA Rat Human +DTXSID7044340 Css NA 0.03292 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044340 Css NA 0.2127 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044340 Css NA 0.04684 mg/L PBTK NA 50% Rat Human +DTXSID7044340 Css NA 0.2421 mg/L PBTK NA 95% Rat Human +DTXSID7044342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044342 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044342 Vd NA 1.84 L/kg 1compartment NA NA Human Human DTXSID7044342 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044342 TK.Half.Life NA 4.79 hours 1compartment NA NA Human Human -DTXSID7044342 Css NA 0.1746 mg/L 3compartmentss NA 50% Human Human -DTXSID7044342 Css NA 1.205 mg/L 3compartmentss NA 95% Human Human -DTXSID7044342 Css NA 0.1178 mg/L PBTK NA 50% Human Human -DTXSID7044342 Css NA 0.7795 mg/L PBTK NA 95% Human Human -DTXSID7044342 Clint NA 88.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044342 Fup NA 0.0636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044342 Vd NA 1.795 L/kg 1compartment NA NA Rat Human +DTXSID7044342 TK.Half.Life NA 5.127 hours 1compartment NA NA Human Human +DTXSID7044342 Css NA 0.2888 mg/L 3compartmentss NA 50% Human Human +DTXSID7044342 Css NA 2.049 mg/L 3compartmentss NA 95% Human Human +DTXSID7044342 Css NA 0.1954 mg/L PBTK NA 50% Human Human +DTXSID7044342 Css NA 1.297 mg/L PBTK NA 95% Human Human +DTXSID7044342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044342 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044342 Vd NA 1.406 L/kg 1compartment NA NA Rat Human DTXSID7044342 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044342 TK.Half.Life NA 1.404 hours 1compartment NA NA Rat Human -DTXSID7044342 Css NA 0.09773 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044342 Css NA 0.5507 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044342 Css NA 0.06234 mg/L PBTK NA 50% Rat Human -DTXSID7044342 Css NA 0.3391 mg/L PBTK NA 95% Rat Human +DTXSID7044342 TK.Half.Life NA 1.815 hours 1compartment NA NA Rat Human +DTXSID7044342 Css NA 0.0363 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044342 Css NA 0.2157 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044342 Css NA 0.02428 mg/L PBTK NA 50% Rat Human +DTXSID7044342 Css NA 0.1345 mg/L PBTK NA 95% Rat Human DTXSID7044346 Clint NA 7467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7044346 Fup NA 0.3952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044346 Vd NA 2.239 L/kg 1compartment NA NA Human Human +DTXSID7044346 Vd NA 0.2888 L/kg 1compartment NA NA Human Human DTXSID7044346 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044346 TK.Half.Life NA 1.514 hours 1compartment NA NA Human Human -DTXSID7044346 Css NA 0.0002329 mg/L 3compartmentss NA 50% Human Human -DTXSID7044346 Css NA 0.001693 mg/L 3compartmentss NA 95% Human Human -DTXSID7044346 Css NA 0.0001882 mg/L PBTK NA 50% Human Human -DTXSID7044346 Css NA 0.001251 mg/L PBTK NA 95% Human Human +DTXSID7044346 TK.Half.Life NA 0.238 hours 1compartment NA NA Human Human +DTXSID7044346 Css NA 4.06e-07 mg/L 3compartmentss NA 50% Human Human +DTXSID7044346 Css NA 2.697e-05 mg/L 3compartmentss NA 95% Human Human +DTXSID7044346 Css NA 2.65e-07 mg/L PBTK NA 50% Human Human +DTXSID7044346 Css NA 1.666e-05 mg/L PBTK NA 95% Human Human DTXSID7044346 Clint NA 7467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7044346 Fup NA 0.3952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044346 Vd NA 1.801 L/kg 1compartment NA NA Rat Human +DTXSID7044346 Vd NA 0.306 L/kg 1compartment NA NA Rat Human DTXSID7044346 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044346 TK.Half.Life NA 0.5231 hours 1compartment NA NA Rat Human -DTXSID7044346 Css NA 0.0001284 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044346 Css NA 0.0008218 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044346 Css NA 0.0001002 mg/L PBTK NA 50% Rat Human -DTXSID7044346 Css NA 0.0005831 mg/L PBTK NA 95% Rat Human +DTXSID7044346 TK.Half.Life NA 0.1091 hours 1compartment NA NA Rat Human +DTXSID7044346 Css NA 1.2e-08 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044346 Css NA 8.71e-07 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044346 Css NA 8e-09 mg/L PBTK NA 50% Rat Human +DTXSID7044346 Css NA 5.39e-07 mg/L PBTK NA 95% Rat Human DTXSID7044390 Clint NA 3.813 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7044390 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044390 Vd NA 0.8255 L/kg 1compartment NA NA Human Human +DTXSID7044390 Vd NA 0.7631 L/kg 1compartment NA NA Human Human DTXSID7044390 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044390 TK.Half.Life NA 1.073 hours 1compartment NA NA Human Human -DTXSID7044390 Css NA 0.1183 mg/L 3compartmentss NA 50% Human Human -DTXSID7044390 Css NA 1.039 mg/L 3compartmentss NA 95% Human Human -DTXSID7044390 Css NA 0.0991 mg/L PBTK NA 50% Human Human -DTXSID7044390 Css NA 0.7037 mg/L PBTK NA 95% Human Human +DTXSID7044390 TK.Half.Life NA 0.9945 hours 1compartment NA NA Human Human +DTXSID7044390 Css NA 0.09496 mg/L 3compartmentss NA 50% Human Human +DTXSID7044390 Css NA 0.8936 mg/L 3compartmentss NA 95% Human Human +DTXSID7044390 Css NA 0.07875 mg/L PBTK NA 50% Human Human +DTXSID7044390 Css NA 0.6111 mg/L PBTK NA 95% Human Human DTXSID7044390 Clint NA 3.813 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7044390 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044390 Vd NA 0.8564 L/kg 1compartment NA NA Rat Human +DTXSID7044390 Vd NA 0.8031 L/kg 1compartment NA NA Rat Human DTXSID7044390 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044390 TK.Half.Life NA 0.5825 hours 1compartment NA NA Rat Human -DTXSID7044390 Css NA 0.05272 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044390 Css NA 0.375 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044390 Css NA 0.04405 mg/L PBTK NA 50% Rat Human -DTXSID7044390 Css NA 0.2329 mg/L PBTK NA 95% Rat Human -DTXSID7044396 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044396 Fup NA 0.6832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044396 Vd NA 0.7026 L/kg 1compartment NA NA Human Human +DTXSID7044390 TK.Half.Life NA 0.5466 hours 1compartment NA NA Rat Human +DTXSID7044390 Css NA 0.003051 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044390 Css NA 0.03133 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044390 Css NA 0.002513 mg/L PBTK NA 50% Rat Human +DTXSID7044390 Css NA 0.02185 mg/L PBTK NA 95% Rat Human +DTXSID7044396 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044396 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044396 Vd NA 0.586 L/kg 1compartment NA NA Human Human DTXSID7044396 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044396 TK.Half.Life NA 1.17 hours 1compartment NA NA Human Human -DTXSID7044396 Css NA 0.1444 mg/L 3compartmentss NA 50% Human Human -DTXSID7044396 Css NA 1.282 mg/L 3compartmentss NA 95% Human Human -DTXSID7044396 Css NA 0.1151 mg/L PBTK NA 50% Human Human -DTXSID7044396 Css NA 0.8517 mg/L PBTK NA 95% Human Human -DTXSID7044396 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044396 Fup NA 0.6832 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044396 Vd NA 0.7189 L/kg 1compartment NA NA Rat Human +DTXSID7044396 TK.Half.Life NA 6.496 hours 1compartment NA NA Human Human +DTXSID7044396 Css NA 1.274 mg/L 3compartmentss NA 50% Human Human +DTXSID7044396 Css NA 8.473 mg/L 3compartmentss NA 95% Human Human +DTXSID7044396 Css NA 0.9802 mg/L PBTK NA 50% Human Human +DTXSID7044396 Css NA 5.304 mg/L PBTK NA 95% Human Human +DTXSID7044396 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044396 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044396 Vd NA 0.609 L/kg 1compartment NA NA Rat Human DTXSID7044396 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044396 TK.Half.Life NA 0.6436 hours 1compartment NA NA Rat Human -DTXSID7044396 Css NA 0.06792 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044396 Css NA 0.5453 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044396 Css NA 0.05296 mg/L PBTK NA 50% Rat Human -DTXSID7044396 Css NA 0.3291 mg/L PBTK NA 95% Rat Human -DTXSID7044398 Clint NA 136.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044398 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044398 Vd NA 2.836 L/kg 1compartment NA NA Human Human -DTXSID7044398 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044398 TK.Half.Life NA 5.078 hours 1compartment NA NA Human Human -DTXSID7044398 Css NA 0.1353 mg/L 3compartmentss NA 50% Human Human -DTXSID7044398 Css NA 0.922 mg/L 3compartmentss NA 95% Human Human -DTXSID7044398 Css NA 0.09512 mg/L PBTK NA 50% Human Human -DTXSID7044398 Css NA 0.6201 mg/L PBTK NA 95% Human Human -DTXSID7044398 Clint NA 136.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044398 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044398 Vd NA 2.185 L/kg 1compartment NA NA Rat Human -DTXSID7044398 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044398 TK.Half.Life NA 1.391 hours 1compartment NA NA Rat Human -DTXSID7044398 Css NA 0.07573 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044398 Css NA 0.4203 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044398 Css NA 0.05104 mg/L PBTK NA 50% Rat Human -DTXSID7044398 Css NA 0.2742 mg/L PBTK NA 95% Rat Human -DTXSID7044421 Clint NA 3.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044421 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044421 Vd NA 1.077 L/kg 1compartment NA NA Human Human +DTXSID7044396 TK.Half.Life NA 2.299 hours 1compartment NA NA Rat Human +DTXSID7044396 Css NA 0.07728 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044396 Css NA 0.482 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044396 Css NA 0.0592 mg/L PBTK NA 50% Rat Human +DTXSID7044396 Css NA 0.29 mg/L PBTK NA 95% Rat Human +DTXSID7044398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044398 Fup 0.0102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044398 Vd NA 1.695 L/kg 1compartment NA NA Human Human +DTXSID7044398 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7044398 TK.Half.Life NA 25.15 hours 1compartment NA NA Human Human +DTXSID7044398 Css NA 2.332 mg/L 3compartmentss NA 50% Human Human +DTXSID7044398 Css NA 21.2 mg/L 3compartmentss NA 95% Human Human +DTXSID7044398 Css NA 1.486 mg/L PBTK NA 50% Human Human +DTXSID7044398 Css NA 12.77 mg/L PBTK NA 95% Human Human +DTXSID7044398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044398 Fup 0.0102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044398 Vd NA 1.283 L/kg 1compartment NA NA Rat Human +DTXSID7044398 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7044398 TK.Half.Life NA 9.603 hours 1compartment NA NA Rat Human +DTXSID7044398 Css NA 0.305 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044398 Css NA 2.322 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044398 Css NA 0.1882 mg/L PBTK NA 50% Rat Human +DTXSID7044398 Css NA 1.35 mg/L PBTK NA 95% Rat Human +DTXSID7044421 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044421 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044421 Vd NA 0.704 L/kg 1compartment NA NA Human Human DTXSID7044421 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044421 TK.Half.Life NA 1.531 hours 1compartment NA NA Human Human -DTXSID7044421 Css NA 0.1284 mg/L 3compartmentss NA 50% Human Human -DTXSID7044421 Css NA 1.09 mg/L 3compartmentss NA 95% Human Human -DTXSID7044421 Css NA 0.1146 mg/L PBTK NA 50% Human Human -DTXSID7044421 Css NA 0.7858 mg/L PBTK NA 95% Human Human -DTXSID7044421 Clint NA 3.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044421 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044421 Vd NA 1.064 L/kg 1compartment NA NA Rat Human +DTXSID7044421 TK.Half.Life NA 0.7057 hours 1compartment NA NA Human Human +DTXSID7044421 Css NA 0.03884 mg/L 3compartmentss NA 50% Human Human +DTXSID7044421 Css NA 0.3569 mg/L 3compartmentss NA 95% Human Human +DTXSID7044421 Css NA 0.03011 mg/L PBTK NA 50% Human Human +DTXSID7044421 Css NA 0.2426 mg/L PBTK NA 95% Human Human +DTXSID7044421 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044421 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044421 Vd NA 0.6922 L/kg 1compartment NA NA Rat Human DTXSID7044421 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044421 TK.Half.Life NA 0.7877 hours 1compartment NA NA Rat Human -DTXSID7044421 Css NA 0.05696 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044421 Css NA 0.4202 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044421 Css NA 0.0508 mg/L PBTK NA 50% Rat Human -DTXSID7044421 Css NA 0.2608 mg/L PBTK NA 95% Rat Human -DTXSID7044425 Clint NA 0.01348 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044425 Fup NA 0.5628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044425 Vd NA 0.4574 L/kg 1compartment NA NA Human Human +DTXSID7044421 TK.Half.Life NA 0.3499 hours 1compartment NA NA Rat Human +DTXSID7044421 Css NA 0.004836 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044421 Css NA 0.03597 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044421 Css NA 0.003746 mg/L PBTK NA 50% Rat Human +DTXSID7044421 Css NA 0.02398 mg/L PBTK NA 95% Rat Human +DTXSID7044425 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044425 Fup 0.878 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044425 Vd NA 0.5601 L/kg 1compartment NA NA Human Human DTXSID7044425 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044425 TK.Half.Life NA 5.138 hours 1compartment NA NA Human Human -DTXSID7044425 Css NA 1.346 mg/L 3compartmentss NA 50% Human Human -DTXSID7044425 Css NA 8.736 mg/L 3compartmentss NA 95% Human Human -DTXSID7044425 Css NA 0.9988 mg/L PBTK NA 50% Human Human -DTXSID7044425 Css NA 5.388 mg/L PBTK NA 95% Human Human -DTXSID7044425 Clint NA 0.01348 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044425 Fup NA 0.5628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044425 Vd NA 0.4699 L/kg 1compartment NA NA Rat Human +DTXSID7044425 TK.Half.Life NA 4.126 hours 1compartment NA NA Human Human +DTXSID7044425 Css NA 0.8469 mg/L 3compartmentss NA 50% Human Human +DTXSID7044425 Css NA 4.732 mg/L 3compartmentss NA 95% Human Human +DTXSID7044425 Css NA 0.6598 mg/L PBTK NA 50% Human Human +DTXSID7044425 Css NA 2.999 mg/L PBTK NA 95% Human Human +DTXSID7044425 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044425 Fup 0.878 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044425 Vd NA 0.5801 L/kg 1compartment NA NA Rat Human DTXSID7044425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044425 TK.Half.Life NA 1.821 hours 1compartment NA NA Rat Human -DTXSID7044425 Css NA 0.368 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044425 Css NA 2.23 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044425 Css NA 0.2589 mg/L PBTK NA 50% Rat Human -DTXSID7044425 Css NA 1.278 mg/L PBTK NA 95% Rat Human +DTXSID7044425 TK.Half.Life NA 1.457 hours 1compartment NA NA Rat Human +DTXSID7044425 Css NA 0.01561 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044425 Css NA 0.1143 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044425 Css NA 0.01162 mg/L PBTK NA 50% Rat Human +DTXSID7044425 Css NA 0.0726 mg/L PBTK NA 95% Rat Human DTXSID7044427 Clint 0.4016 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID7044427 Fup 0.9528 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID7044427 Vd NA 0.7675 L/kg 1compartment NA NA Human Human +DTXSID7044427 Vd NA 0.755 L/kg 1compartment NA NA Human Human DTXSID7044427 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044427 TK.Half.Life NA 3.203 hours 1compartment NA NA Human Human -DTXSID7044427 Css NA 0.4696 mg/L 3compartmentss NA 50% Human Human -DTXSID7044427 Css NA 1.397 mg/L 3compartmentss NA 95% Human Human -DTXSID7044427 Css NA 0.3956 mg/L PBTK NA 50% Human Human -DTXSID7044427 Css NA 1.048 mg/L PBTK NA 95% Human Human +DTXSID7044427 TK.Half.Life NA 3.149 hours 1compartment NA NA Human Human +DTXSID7044427 Css NA 0.4618 mg/L 3compartmentss NA 50% Human Human +DTXSID7044427 Css NA 1.396 mg/L 3compartmentss NA 95% Human Human +DTXSID7044427 Css NA 0.3886 mg/L PBTK NA 50% Human Human +DTXSID7044427 Css NA 1.032 mg/L PBTK NA 95% Human Human DTXSID7044427 Clint 0.4016 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID7044427 Fup 0.9528 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID7044427 Vd NA 0.8032 L/kg 1compartment NA NA Rat Human +DTXSID7044427 Vd NA 0.7925 L/kg 1compartment NA NA Rat Human DTXSID7044427 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044427 TK.Half.Life NA 1.417 hours 1compartment NA NA Rat Human -DTXSID7044427 Css NA 0.1539 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044427 Css NA 0.3823 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044427 Css NA 0.1289 mg/L PBTK NA 50% Rat Human -DTXSID7044427 Css NA 0.2637 mg/L PBTK NA 95% Rat Human -DTXSID7044429 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044429 Fup NA 0.13 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044429 Vd NA 0.9617 L/kg 1compartment NA NA Human Human -DTXSID7044429 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID7044429 TK.Half.Life NA 53.57 hours 1compartment NA NA Human Human -DTXSID7044429 Css NA 7.837 mg/L 3compartmentss NA 50% Human Human -DTXSID7044429 Css NA 35.68 mg/L 3compartmentss NA 95% Human Human -DTXSID7044429 Css NA 5.158 mg/L PBTK NA 50% Human Human -DTXSID7044429 Css NA 21.72 mg/L PBTK NA 95% Human Human -DTXSID7044429 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044429 Fup NA 0.13 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044429 Vd NA 0.7727 L/kg 1compartment NA NA Rat Human -DTXSID7044429 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7044429 TK.Half.Life NA 13.48 hours 1compartment NA NA Rat Human -DTXSID7044429 Css NA 2.198 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044429 Css NA 8.241 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044429 Css NA 1.368 mg/L PBTK NA 50% Rat Human -DTXSID7044429 Css NA 4.65 mg/L PBTK NA 95% Rat Human -DTXSID7044471 Clint NA 51.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044471 Fup NA 0.8557 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044471 Vd NA 1.15 L/kg 1compartment NA NA Human Human +DTXSID7044427 TK.Half.Life NA 1.398 hours 1compartment NA NA Rat Human +DTXSID7044427 Css NA 0.03548 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044427 Css NA 0.08934 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044427 Css NA 0.03045 mg/L PBTK NA 50% Rat Human +DTXSID7044427 Css NA 0.06328 mg/L PBTK NA 95% Rat Human +DTXSID7044429 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044429 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044429 Vd NA 0.6404 L/kg 1compartment NA NA Human Human +DTXSID7044429 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7044429 TK.Half.Life NA 3.31 hours 1compartment NA NA Human Human +DTXSID7044429 Css NA 0.6746 mg/L 3compartmentss NA 50% Human Human +DTXSID7044429 Css NA 4.727 mg/L 3compartmentss NA 95% Human Human +DTXSID7044429 Css NA 0.4369 mg/L PBTK NA 50% Human Human +DTXSID7044429 Css NA 2.859 mg/L PBTK NA 95% Human Human +DTXSID7044429 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044429 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044429 Vd NA 0.5455 L/kg 1compartment NA NA Rat Human +DTXSID7044429 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7044429 TK.Half.Life NA 1.662 hours 1compartment NA NA Rat Human +DTXSID7044429 Css NA 0.08286 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044429 Css NA 0.4318 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044429 Css NA 0.0521 mg/L PBTK NA 50% Rat Human +DTXSID7044429 Css NA 0.2529 mg/L PBTK NA 95% Rat Human +DTXSID7044471 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044471 Fup 0.483 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044471 Vd NA 0.817 L/kg 1compartment NA NA Human Human DTXSID7044471 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044471 TK.Half.Life NA 0.7149 hours 1compartment NA NA Human Human -DTXSID7044471 Css NA 0.01122 mg/L 3compartmentss NA 50% Human Human -DTXSID7044471 Css NA 0.1192 mg/L 3compartmentss NA 95% Human Human -DTXSID7044471 Css NA 0.009886 mg/L PBTK NA 50% Human Human -DTXSID7044471 Css NA 0.08704 mg/L PBTK NA 95% Human Human -DTXSID7044471 Clint NA 51.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044471 Fup NA 0.8557 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044471 Vd NA 1.097 L/kg 1compartment NA NA Rat Human +DTXSID7044471 TK.Half.Life NA 0.8216 hours 1compartment NA NA Human Human +DTXSID7044471 Css NA 0.03963 mg/L 3compartmentss NA 50% Human Human +DTXSID7044471 Css NA 0.3644 mg/L 3compartmentss NA 95% Human Human +DTXSID7044471 Css NA 0.03106 mg/L PBTK NA 50% Human Human +DTXSID7044471 Css NA 0.2501 mg/L PBTK NA 95% Human Human +DTXSID7044471 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044471 Fup 0.483 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044471 Vd NA 0.7754 L/kg 1compartment NA NA Rat Human DTXSID7044471 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044471 TK.Half.Life NA 0.3111 hours 1compartment NA NA Rat Human -DTXSID7044471 Css NA 0.005753 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044471 Css NA 0.05378 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044471 Css NA 0.005005 mg/L PBTK NA 50% Rat Human -DTXSID7044471 Css NA 0.03856 mg/L PBTK NA 95% Rat Human -DTXSID7044473 Clint NA 0.01914 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044473 Fup NA 0.1416 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044473 Vd NA 0.3723 L/kg 1compartment NA NA Human Human -DTXSID7044473 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7044473 TK.Half.Life NA 16.48 hours 1compartment NA NA Human Human -DTXSID7044473 Css NA 6.344 mg/L 3compartmentss NA 50% Human Human -DTXSID7044473 Css NA 29.63 mg/L 3compartmentss NA 95% Human Human -DTXSID7044473 Css NA 4.055 mg/L PBTK NA 50% Human Human -DTXSID7044473 Css NA 17.81 mg/L PBTK NA 95% Human Human -DTXSID7044473 Clint NA 0.01914 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044473 Fup NA 0.1416 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044473 Vd NA 0.3729 L/kg 1compartment NA NA Rat Human +DTXSID7044471 TK.Half.Life NA 0.3934 hours 1compartment NA NA Rat Human +DTXSID7044471 Css NA 0.004788 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044471 Css NA 0.0342 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044471 Css NA 0.003788 mg/L PBTK NA 50% Rat Human +DTXSID7044471 Css NA 0.02314 mg/L PBTK NA 95% Rat Human +DTXSID7044473 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044473 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044473 Vd NA 0.4886 L/kg 1compartment NA NA Human Human +DTXSID7044473 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7044473 TK.Half.Life NA 1.273 hours 1compartment NA NA Human Human +DTXSID7044473 Css NA 0.2316 mg/L 3compartmentss NA 50% Human Human +DTXSID7044473 Css NA 1.493 mg/L 3compartmentss NA 95% Human Human +DTXSID7044473 Css NA 0.1637 mg/L PBTK NA 50% Human Human +DTXSID7044473 Css NA 0.9519 mg/L PBTK NA 95% Human Human +DTXSID7044473 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044473 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044473 Vd NA 0.4954 L/kg 1compartment NA NA Rat Human DTXSID7044473 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044473 TK.Half.Life NA 5.719 hours 1compartment NA NA Rat Human -DTXSID7044473 Css NA 1.807 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044473 Css NA 7.277 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044473 Css NA 1.094 mg/L PBTK NA 50% Rat Human -DTXSID7044473 Css NA 4.057 mg/L PBTK NA 95% Rat Human -DTXSID7044479 Clint NA 91.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044479 Fup NA 0.0775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044479 Vd NA 1.545 L/kg 1compartment NA NA Human Human +DTXSID7044473 TK.Half.Life NA 0.7413 hours 1compartment NA NA Rat Human +DTXSID7044473 Css NA 0.02732 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044473 Css NA 0.1281 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044473 Css NA 0.01898 mg/L PBTK NA 50% Rat Human +DTXSID7044473 Css NA 0.08003 mg/L PBTK NA 95% Rat Human +DTXSID7044479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044479 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044479 Vd NA 1.807 L/kg 1compartment NA NA Human Human DTXSID7044479 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044479 TK.Half.Life NA 2.288 hours 1compartment NA NA Human Human -DTXSID7044479 Css NA 0.1024 mg/L 3compartmentss NA 50% Human Human -DTXSID7044479 Css NA 0.8092 mg/L 3compartmentss NA 95% Human Human -DTXSID7044479 Css NA 0.06707 mg/L PBTK NA 50% Human Human -DTXSID7044479 Css NA 0.505 mg/L PBTK NA 95% Human Human -DTXSID7044479 Clint NA 91.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044479 Fup NA 0.0775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044479 Vd NA 1.172 L/kg 1compartment NA NA Rat Human +DTXSID7044479 TK.Half.Life NA 4.009 hours 1compartment NA NA Human Human +DTXSID7044479 Css NA 0.1902 mg/L 3compartmentss NA 50% Human Human +DTXSID7044479 Css NA 1.327 mg/L 3compartmentss NA 95% Human Human +DTXSID7044479 Css NA 0.1329 mg/L PBTK NA 50% Human Human +DTXSID7044479 Css NA 0.882 mg/L PBTK NA 95% Human Human +DTXSID7044479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044479 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044479 Vd NA 1.392 L/kg 1compartment NA NA Rat Human DTXSID7044479 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044479 TK.Half.Life NA 0.8298 hours 1compartment NA NA Rat Human -DTXSID7044479 Css NA 0.05799 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044479 Css NA 0.3683 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044479 Css NA 0.03586 mg/L PBTK NA 50% Rat Human -DTXSID7044479 Css NA 0.2164 mg/L PBTK NA 95% Rat Human -DTXSID7044500 Clint NA 3.801 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044500 Fup NA 0.0364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044500 Vd NA 3.117 L/kg 1compartment NA NA Human Human -DTXSID7044500 Days.Css NA 104 Days PBTK NA NA Human Human -DTXSID7044500 TK.Half.Life NA 448.3 hours 1compartment NA NA Human Human -DTXSID7044500 Css NA 17.97 mg/L 3compartmentss NA 50% Human Human -DTXSID7044500 Css NA 106.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7044500 Css NA 12.5 mg/L PBTK NA 50% Human Human -DTXSID7044500 Css NA 71.18 mg/L PBTK NA 95% Human Human -DTXSID7044500 Clint NA 3.801 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044500 Fup NA 0.0364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044500 Vd NA 2.335 L/kg 1compartment NA NA Rat Human -DTXSID7044500 Days.Css NA 56 Days PBTK NA NA Rat Human -DTXSID7044500 TK.Half.Life NA 58.25 hours 1compartment NA NA Rat Human -DTXSID7044500 Css NA 9.998 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044500 Css NA 49.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044500 Css NA 6.631 mg/L PBTK NA 50% Rat Human -DTXSID7044500 Css NA 30.9 mg/L PBTK NA 95% Rat Human -DTXSID7044502 Clint NA 188.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044502 Fup NA 0.5892 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044502 Vd NA 1.006 L/kg 1compartment NA NA Human Human +DTXSID7044479 TK.Half.Life NA 1.44 hours 1compartment NA NA Rat Human +DTXSID7044479 Css NA 0.02384 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044479 Css NA 0.1336 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044479 Css NA 0.01653 mg/L PBTK NA 50% Rat Human +DTXSID7044479 Css NA 0.08686 mg/L PBTK NA 95% Rat Human +DTXSID7044500 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044500 Fup 0.0193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044500 Vd NA 5.066 L/kg 1compartment NA NA Human Human +DTXSID7044500 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID7044500 TK.Half.Life NA 152.2 hours 1compartment NA NA Human Human +DTXSID7044500 Css NA 2.886 mg/L 3compartmentss NA 50% Human Human +DTXSID7044500 Css NA 17.14 mg/L 3compartmentss NA 95% Human Human +DTXSID7044500 Css NA 2.36 mg/L PBTK NA 50% Human Human +DTXSID7044500 Css NA 13.57 mg/L PBTK NA 95% Human Human +DTXSID7044500 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044500 Fup 0.0193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044500 Vd NA 3.871 L/kg 1compartment NA NA Rat Human +DTXSID7044500 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID7044500 TK.Half.Life NA 20.59 hours 1compartment NA NA Rat Human +DTXSID7044500 Css NA 0.3772 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044500 Css NA 1.842 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044500 Css NA 0.3075 mg/L PBTK NA 50% Rat Human +DTXSID7044500 Css NA 1.584 mg/L PBTK NA 95% Rat Human +DTXSID7044502 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044502 Fup 0.455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044502 Vd NA 0.6348 L/kg 1compartment NA NA Human Human DTXSID7044502 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044502 TK.Half.Life NA 0.6595 hours 1compartment NA NA Human Human -DTXSID7044502 Css NA 0.00414 mg/L 3compartmentss NA 50% Human Human -DTXSID7044502 Css NA 0.05032 mg/L 3compartmentss NA 95% Human Human -DTXSID7044502 Css NA 0.003418 mg/L PBTK NA 50% Human Human -DTXSID7044502 Css NA 0.03462 mg/L PBTK NA 95% Human Human -DTXSID7044502 Clint NA 188.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044502 Fup NA 0.5892 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044502 Vd NA 0.937 L/kg 1compartment NA NA Rat Human +DTXSID7044502 TK.Half.Life NA 9.08 hours 1compartment NA NA Human Human +DTXSID7044502 Css NA 1.518 mg/L 3compartmentss NA 50% Human Human +DTXSID7044502 Css NA 7.322 mg/L 3compartmentss NA 95% Human Human +DTXSID7044502 Css NA 1.156 mg/L PBTK NA 50% Human Human +DTXSID7044502 Css NA 4.665 mg/L PBTK NA 95% Human Human +DTXSID7044502 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044502 Fup 0.455 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044502 Vd NA 0.6312 L/kg 1compartment NA NA Rat Human DTXSID7044502 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044502 TK.Half.Life NA 0.2716 hours 1compartment NA NA Rat Human -DTXSID7044502 Css NA 0.002266 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044502 Css NA 0.02276 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044502 Css NA 0.001827 mg/L PBTK NA 50% Rat Human -DTXSID7044502 Css NA 0.01501 mg/L PBTK NA 95% Rat Human -DTXSID7044504 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044504 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044504 Vd NA 0.961 L/kg 1compartment NA NA Human Human -DTXSID7044504 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044504 TK.Half.Life NA 6.273 hours 1compartment NA NA Human Human -DTXSID7044504 Css NA 0.7861 mg/L 3compartmentss NA 50% Human Human -DTXSID7044504 Css NA 5.602 mg/L 3compartmentss NA 95% Human Human -DTXSID7044504 Css NA 0.695 mg/L PBTK NA 50% Human Human -DTXSID7044504 Css NA 3.71 mg/L PBTK NA 95% Human Human -DTXSID7044504 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044504 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044504 Vd NA 0.9712 L/kg 1compartment NA NA Rat Human -DTXSID7044504 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044504 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human -DTXSID7044504 Css NA 0.1988 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044504 Css NA 1.259 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044504 Css NA 0.1728 mg/L PBTK NA 50% Rat Human -DTXSID7044504 Css NA 0.7725 mg/L PBTK NA 95% Rat Human -DTXSID7044508 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044508 Fup NA 0.7222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044508 Vd NA 0.7411 L/kg 1compartment NA NA Human Human -DTXSID7044508 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044508 TK.Half.Life NA 6.665 hours 1compartment NA NA Human Human -DTXSID7044508 Css NA 1.058 mg/L 3compartmentss NA 50% Human Human -DTXSID7044508 Css NA 6.885 mg/L 3compartmentss NA 95% Human Human -DTXSID7044508 Css NA 0.8682 mg/L PBTK NA 50% Human Human -DTXSID7044508 Css NA 4.4 mg/L PBTK NA 95% Human Human -DTXSID7044508 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044508 Fup NA 0.7222 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044508 Vd NA 0.756 L/kg 1compartment NA NA Rat Human -DTXSID7044508 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044508 TK.Half.Life NA 2.31 hours 1compartment NA NA Rat Human -DTXSID7044508 Css NA 0.2758 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044508 Css NA 1.717 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044508 Css NA 0.2181 mg/L PBTK NA 50% Rat Human -DTXSID7044508 Css NA 1.02 mg/L PBTK NA 95% Rat Human -DTXSID7044552 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044552 Fup NA 0.4846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044552 Vd NA 1.108 L/kg 1compartment NA NA Human Human -DTXSID7044552 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7044552 TK.Half.Life NA 14.82 hours 1compartment NA NA Human Human -DTXSID7044552 Css NA 1.16 mg/L 3compartmentss NA 50% Human Human -DTXSID7044552 Css NA 6.578 mg/L 3compartmentss NA 95% Human Human -DTXSID7044552 Css NA 1.136 mg/L PBTK NA 50% Human Human -DTXSID7044552 Css NA 4.64 mg/L PBTK NA 95% Human Human -DTXSID7044552 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044552 Fup NA 0.4846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044552 Vd NA 1.11 L/kg 1compartment NA NA Rat Human -DTXSID7044552 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044552 TK.Half.Life NA 5.052 hours 1compartment NA NA Rat Human -DTXSID7044552 Css NA 0.3093 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044552 Css NA 1.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044552 Css NA 0.2945 mg/L PBTK NA 50% Rat Human -DTXSID7044552 Css NA 1.054 mg/L PBTK NA 95% Rat Human -DTXSID7044554 Clint NA 1.839 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044554 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044554 Vd NA 0.1954 L/kg 1compartment NA NA Human Human -DTXSID7044554 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7044554 TK.Half.Life NA 11.78 hours 1compartment NA NA Human Human -DTXSID7044554 Css NA 10.92 mg/L 3compartmentss NA 50% Human Human -DTXSID7044554 Css NA 77.71 mg/L 3compartmentss NA 95% Human Human -DTXSID7044554 Css NA 6.41 mg/L PBTK NA 50% Human Human -DTXSID7044554 Css NA 44.53 mg/L PBTK NA 95% Human Human -DTXSID7044554 Clint NA 1.839 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044554 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044554 Vd NA 0.1923 L/kg 1compartment NA NA Rat Human +DTXSID7044502 TK.Half.Life NA 3.062 hours 1compartment NA NA Rat Human +DTXSID7044502 Css NA 0.09764 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044502 Css NA 0.3933 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044502 Css NA 0.07344 mg/L PBTK NA 50% Rat Human +DTXSID7044502 Css NA 0.243 mg/L PBTK NA 95% Rat Human +DTXSID7044506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044506 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044506 Vd NA 1.475 L/kg 1compartment NA NA Human Human +DTXSID7044506 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7044506 TK.Half.Life NA 2.52 hours 1compartment NA NA Human Human +DTXSID7044506 Css NA 0.1152 mg/L 3compartmentss NA 50% Human Human +DTXSID7044506 Css NA 0.7783 mg/L 3compartmentss NA 95% Human Human +DTXSID7044506 Css NA 0.0829 mg/L PBTK NA 50% Human Human +DTXSID7044506 Css NA 0.5254 mg/L PBTK NA 95% Human Human +DTXSID7044506 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044506 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044506 Vd NA 1.169 L/kg 1compartment NA NA Rat Human +DTXSID7044506 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7044506 TK.Half.Life NA 0.9942 hours 1compartment NA NA Rat Human +DTXSID7044506 Css NA 0.01434 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044506 Css NA 0.07529 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044506 Css NA 0.01027 mg/L PBTK NA 50% Rat Human +DTXSID7044506 Css NA 0.05123 mg/L PBTK NA 95% Rat Human +DTXSID7044554 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044554 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044554 Vd NA 0.3187 L/kg 1compartment NA NA Human Human +DTXSID7044554 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7044554 TK.Half.Life NA 1.815 hours 1compartment NA NA Human Human +DTXSID7044554 Css NA 0.4306 mg/L 3compartmentss NA 50% Human Human +DTXSID7044554 Css NA 3.114 mg/L 3compartmentss NA 95% Human Human +DTXSID7044554 Css NA 0.2714 mg/L PBTK NA 50% Human Human +DTXSID7044554 Css NA 1.878 mg/L PBTK NA 95% Human Human +DTXSID7044554 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044554 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044554 Vd NA 0.3117 L/kg 1compartment NA NA Rat Human DTXSID7044554 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044554 TK.Half.Life NA 6.412 hours 1compartment NA NA Rat Human -DTXSID7044554 Css NA 5.003 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044554 Css NA 29.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044554 Css NA 2.754 mg/L PBTK NA 50% Rat Human -DTXSID7044554 Css NA 15.77 mg/L PBTK NA 95% Rat Human -DTXSID7044631 Clint NA 3.991 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044631 Fup NA 0.4113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044631 Vd NA 0.6931 L/kg 1compartment NA NA Human Human +DTXSID7044554 TK.Half.Life NA 1.075 hours 1compartment NA NA Rat Human +DTXSID7044554 Css NA 0.004334 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044554 Css NA 0.02718 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044554 Css NA 0.002576 mg/L PBTK NA 50% Rat Human +DTXSID7044554 Css NA 0.01538 mg/L PBTK NA 95% Rat Human +DTXSID7044631 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044631 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044631 Vd NA 0.5344 L/kg 1compartment NA NA Human Human DTXSID7044631 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044631 TK.Half.Life NA 1.816 hours 1compartment NA NA Human Human -DTXSID7044631 Css NA 0.2444 mg/L 3compartmentss NA 50% Human Human -DTXSID7044631 Css NA 1.477 mg/L 3compartmentss NA 95% Human Human -DTXSID7044631 Css NA 0.1856 mg/L PBTK NA 50% Human Human -DTXSID7044631 Css NA 0.986 mg/L PBTK NA 95% Human Human -DTXSID7044631 Clint NA 3.991 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044631 Fup NA 0.4113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044631 Vd NA 0.667 L/kg 1compartment NA NA Rat Human +DTXSID7044631 TK.Half.Life NA 1.104 hours 1compartment NA NA Human Human +DTXSID7044631 Css NA 0.1657 mg/L 3compartmentss NA 50% Human Human +DTXSID7044631 Css NA 1.123 mg/L 3compartmentss NA 95% Human Human +DTXSID7044631 Css NA 0.1199 mg/L PBTK NA 50% Human Human +DTXSID7044631 Css NA 0.736 mg/L PBTK NA 95% Human Human +DTXSID7044631 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044631 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044631 Vd NA 0.541 L/kg 1compartment NA NA Rat Human DTXSID7044631 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044631 TK.Half.Life NA 0.9682 hours 1compartment NA NA Rat Human -DTXSID7044631 Css NA 0.1152 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044631 Css NA 0.5671 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044631 Css NA 0.0838 mg/L PBTK NA 50% Rat Human -DTXSID7044631 Css NA 0.3504 mg/L PBTK NA 95% Rat Human +DTXSID7044631 TK.Half.Life NA 0.6239 hours 1compartment NA NA Rat Human +DTXSID7044631 Css NA 0.0194 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044631 Css NA 0.09622 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044631 Css NA 0.01402 mg/L PBTK NA 50% Rat Human +DTXSID7044631 Css NA 0.06105 mg/L PBTK NA 95% Rat Human DTXSID7044633 Clint 4.9 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID7044633 Fup NA 0.0692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044633 Vd NA 0.2352 L/kg 1compartment NA NA Human Human +DTXSID7044633 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044633 Vd NA 0.4599 L/kg 1compartment NA NA Human Human DTXSID7044633 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044633 TK.Half.Life NA 2.585 hours 1compartment NA NA Human Human -DTXSID7044633 Css NA 1.834 mg/L 3compartmentss NA 50% Human Human -DTXSID7044633 Css NA 11.49 mg/L 3compartmentss NA 95% Human Human -DTXSID7044633 Css NA 1.098 mg/L PBTK NA 50% Human Human -DTXSID7044633 Css NA 6.749 mg/L PBTK NA 95% Human Human +DTXSID7044633 TK.Half.Life NA 2.298 hours 1compartment NA NA Human Human +DTXSID7044633 Css NA 0.5844 mg/L 3compartmentss NA 50% Human Human +DTXSID7044633 Css NA 3.609 mg/L 3compartmentss NA 95% Human Human +DTXSID7044633 Css NA 0.3817 mg/L PBTK NA 50% Human Human +DTXSID7044633 Css NA 2.203 mg/L PBTK NA 95% Human Human DTXSID7044633 Clint 4.9 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID7044633 Fup NA 0.0692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044633 Vd NA 0.2289 L/kg 1compartment NA NA Rat Human +DTXSID7044633 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044633 Vd NA 0.4142 L/kg 1compartment NA NA Rat Human DTXSID7044633 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044633 TK.Half.Life NA 1.535 hours 1compartment NA NA Rat Human -DTXSID7044633 Css NA 0.952 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044633 Css NA 4.373 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044633 Css NA 0.5337 mg/L PBTK NA 50% Rat Human -DTXSID7044633 Css NA 2.394 mg/L PBTK NA 95% Rat Human +DTXSID7044633 TK.Half.Life NA 1.213 hours 1compartment NA NA Rat Human +DTXSID7044633 Css NA 0.06966 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044633 Css NA 0.3062 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044633 Css NA 0.04426 mg/L PBTK NA 50% Rat Human +DTXSID7044633 Css NA 0.182 mg/L PBTK NA 95% Rat Human DTXSID7044635 Clint NA 3.508 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7044635 Fup NA 0.198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044635 Vd NA 0.4097 L/kg 1compartment NA NA Human Human +DTXSID7044635 Vd NA 0.296 L/kg 1compartment NA NA Human Human DTXSID7044635 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044635 TK.Half.Life NA 2.18 hours 1compartment NA NA Human Human -DTXSID7044635 Css NA 0.602 mg/L 3compartmentss NA 50% Human Human -DTXSID7044635 Css NA 3.175 mg/L 3compartmentss NA 95% Human Human -DTXSID7044635 Css NA 0.4026 mg/L PBTK NA 50% Human Human -DTXSID7044635 Css NA 1.975 mg/L PBTK NA 95% Human Human +DTXSID7044635 TK.Half.Life NA 0.3513 hours 1compartment NA NA Human Human +DTXSID7044635 Css NA 0.03314 mg/L 3compartmentss NA 50% Human Human +DTXSID7044635 Css NA 0.2827 mg/L 3compartmentss NA 95% Human Human +DTXSID7044635 Css NA 0.02122 mg/L PBTK NA 50% Human Human +DTXSID7044635 Css NA 0.1743 mg/L PBTK NA 95% Human Human DTXSID7044635 Clint NA 3.508 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7044635 Fup NA 0.198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044635 Vd NA 0.4136 L/kg 1compartment NA NA Rat Human +DTXSID7044635 Vd NA 0.3134 L/kg 1compartment NA NA Rat Human DTXSID7044635 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044635 TK.Half.Life NA 1.27 hours 1compartment NA NA Rat Human -DTXSID7044635 Css NA 0.293 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044635 Css NA 1.122 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044635 Css NA 0.1867 mg/L PBTK NA 50% Rat Human -DTXSID7044635 Css NA 0.6533 mg/L PBTK NA 95% Rat Human -DTXSID7044681 Clint NA 14.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044681 Fup NA 0.0909 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044681 Vd NA 2.216 L/kg 1compartment NA NA Human Human -DTXSID7044681 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044681 TK.Half.Life NA 2.801 hours 1compartment NA NA Human Human -DTXSID7044681 Css NA 0.084 mg/L 3compartmentss NA 50% Human Human -DTXSID7044681 Css NA 0.789 mg/L 3compartmentss NA 95% Human Human -DTXSID7044681 Css NA 0.07726 mg/L PBTK NA 50% Human Human -DTXSID7044681 Css NA 0.5958 mg/L PBTK NA 95% Human Human -DTXSID7044681 Clint NA 14.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044681 Fup NA 0.0909 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044681 Vd NA 2.155 L/kg 1compartment NA NA Rat Human +DTXSID7044635 TK.Half.Life NA 0.1866 hours 1compartment NA NA Rat Human +DTXSID7044635 Css NA 0.001234 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044635 Css NA 0.01168 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044635 Css NA 0.000754 mg/L PBTK NA 50% Rat Human +DTXSID7044635 Css NA 0.006934 mg/L PBTK NA 95% Rat Human +DTXSID7044639 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7044639 Fup NA 0.0406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7044639 Vd NA 0.5571 L/kg 1compartment NA NA Human Human +DTXSID7044639 Days.Css NA 19 Days PBTK NA NA Human Human +DTXSID7044639 TK.Half.Life NA 92.58 hours 1compartment NA NA Human Human +DTXSID7044639 Css NA 27.5 mg/L 3compartmentss NA 50% Human Human +DTXSID7044639 Css NA 152.5 mg/L 3compartmentss NA 95% Human Human +DTXSID7044639 Css NA 16.65 mg/L PBTK NA 50% Human Human +DTXSID7044639 Css NA 90.25 mg/L PBTK NA 95% Human Human +DTXSID7044639 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7044639 Fup NA 0.0406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7044639 Vd NA 0.4449 L/kg 1compartment NA NA Rat Human +DTXSID7044639 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7044639 TK.Half.Life NA 24.42 hours 1compartment NA NA Rat Human +DTXSID7044639 Css NA 1.79 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044639 Css NA 8.517 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044639 Css NA 1.05 mg/L PBTK NA 50% Rat Human +DTXSID7044639 Css NA 4.811 mg/L PBTK NA 95% Rat Human +DTXSID7044681 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044681 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044681 Vd NA 0.7954 L/kg 1compartment NA NA Human Human +DTXSID7044681 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7044681 TK.Half.Life NA 13.26 hours 1compartment NA NA Human Human +DTXSID7044681 Css NA 1.721 mg/L 3compartmentss NA 50% Human Human +DTXSID7044681 Css NA 7.678 mg/L 3compartmentss NA 95% Human Human +DTXSID7044681 Css NA 1.331 mg/L PBTK NA 50% Human Human +DTXSID7044681 Css NA 5.05 mg/L PBTK NA 95% Human Human +DTXSID7044681 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044681 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044681 Vd NA 0.8171 L/kg 1compartment NA NA Rat Human DTXSID7044681 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044681 TK.Half.Life NA 1.555 hours 1compartment NA NA Rat Human -DTXSID7044681 Css NA 0.0461 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044681 Css NA 0.3713 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044681 Css NA 0.04105 mg/L PBTK NA 50% Rat Human -DTXSID7044681 Css NA 0.2727 mg/L PBTK NA 95% Rat Human -DTXSID7044689 Clint NA 4.092 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044689 Fup NA 0.5553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044689 Vd NA 1.1 L/kg 1compartment NA NA Human Human +DTXSID7044681 TK.Half.Life NA 4.643 hours 1compartment NA NA Rat Human +DTXSID7044681 Css NA 0.109 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044681 Css NA 0.4191 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044681 Css NA 0.084 mg/L PBTK NA 50% Rat Human +DTXSID7044681 Css NA 0.2628 mg/L PBTK NA 95% Rat Human +DTXSID7044685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044685 Fup 0.0581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044685 Vd NA 2.662 L/kg 1compartment NA NA Human Human +DTXSID7044685 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7044685 TK.Half.Life NA 19.78 hours 1compartment NA NA Human Human +DTXSID7044685 Css NA 0.9068 mg/L 3compartmentss NA 50% Human Human +DTXSID7044685 Css NA 5.773 mg/L 3compartmentss NA 95% Human Human +DTXSID7044685 Css NA 0.618 mg/L PBTK NA 50% Human Human +DTXSID7044685 Css NA 3.823 mg/L PBTK NA 95% Human Human +DTXSID7044685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044685 Fup 0.0581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044685 Vd NA 1.996 L/kg 1compartment NA NA Rat Human +DTXSID7044685 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7044685 TK.Half.Life NA 4.516 hours 1compartment NA NA Rat Human +DTXSID7044685 Css NA 0.1175 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044685 Css NA 0.6517 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044685 Css NA 0.07884 mg/L PBTK NA 50% Rat Human +DTXSID7044685 Css NA 0.417 mg/L PBTK NA 95% Rat Human +DTXSID7044687 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044687 Fup 0.735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044687 Vd NA 0.5963 L/kg 1compartment NA NA Human Human +DTXSID7044687 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7044687 TK.Half.Life NA 5.247 hours 1compartment NA NA Human Human +DTXSID7044687 Css NA 1.043 mg/L 3compartmentss NA 50% Human Human +DTXSID7044687 Css NA 6.781 mg/L 3compartmentss NA 95% Human Human +DTXSID7044687 Css NA 0.8237 mg/L PBTK NA 50% Human Human +DTXSID7044687 Css NA 4.237 mg/L PBTK NA 95% Human Human +DTXSID7044687 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044687 Fup 0.735 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044687 Vd NA 0.635 L/kg 1compartment NA NA Rat Human +DTXSID7044687 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7044687 TK.Half.Life NA 1.905 hours 1compartment NA NA Rat Human +DTXSID7044687 Css NA 0.06104 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044687 Css NA 0.3865 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044687 Css NA 0.0482 mg/L PBTK NA 50% Rat Human +DTXSID7044687 Css NA 0.2349 mg/L PBTK NA 95% Rat Human +DTXSID7044689 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044689 Fup 0.41 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044689 Vd NA 0.7497 L/kg 1compartment NA NA Human Human DTXSID7044689 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044689 TK.Half.Life NA 2.255 hours 1compartment NA NA Human Human -DTXSID7044689 Css NA 0.1759 mg/L 3compartmentss NA 50% Human Human -DTXSID7044689 Css NA 1.459 mg/L 3compartmentss NA 95% Human Human -DTXSID7044689 Css NA 0.1458 mg/L PBTK NA 50% Human Human -DTXSID7044689 Css NA 0.9806 mg/L PBTK NA 95% Human Human -DTXSID7044689 Clint NA 4.092 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044689 Fup NA 0.5553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044689 Vd NA 0.9976 L/kg 1compartment NA NA Rat Human +DTXSID7044689 TK.Half.Life NA 1.494 hours 1compartment NA NA Human Human +DTXSID7044689 Css NA 0.156 mg/L 3compartmentss NA 50% Human Human +DTXSID7044689 Css NA 1.057 mg/L 3compartmentss NA 95% Human Human +DTXSID7044689 Css NA 0.1184 mg/L PBTK NA 50% Human Human +DTXSID7044689 Css NA 0.7109 mg/L PBTK NA 95% Human Human +DTXSID7044689 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044689 Fup 0.41 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044689 Vd NA 0.7092 L/kg 1compartment NA NA Rat Human DTXSID7044689 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044689 TK.Half.Life NA 1.084 hours 1compartment NA NA Rat Human -DTXSID7044689 Css NA 0.08403 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044689 Css NA 0.6171 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044689 Css NA 0.06765 mg/L PBTK NA 50% Rat Human -DTXSID7044689 Css NA 0.3739 mg/L PBTK NA 95% Rat Human -DTXSID7044710 Clint NA 9.852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044710 Fup NA 0.132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044710 Vd NA 1.025 L/kg 1compartment NA NA Human Human +DTXSID7044689 TK.Half.Life NA 0.7822 hours 1compartment NA NA Rat Human +DTXSID7044689 Css NA 0.01824 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044689 Css NA 0.09314 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044689 Css NA 0.01385 mg/L PBTK NA 50% Rat Human +DTXSID7044689 Css NA 0.06032 mg/L PBTK NA 95% Rat Human +DTXSID7044710 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044710 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044710 Vd NA 0.8769 L/kg 1compartment NA NA Human Human DTXSID7044710 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044710 TK.Half.Life NA 3.809 hours 1compartment NA NA Human Human -DTXSID7044710 Css NA 0.4488 mg/L 3compartmentss NA 50% Human Human -DTXSID7044710 Css NA 3.25 mg/L 3compartmentss NA 95% Human Human -DTXSID7044710 Css NA 0.2992 mg/L PBTK NA 50% Human Human -DTXSID7044710 Css NA 2.043 mg/L PBTK NA 95% Human Human -DTXSID7044710 Clint NA 9.852 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044710 Fup NA 0.132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044710 Vd NA 0.8182 L/kg 1compartment NA NA Rat Human +DTXSID7044710 TK.Half.Life NA 2.026 hours 1compartment NA NA Human Human +DTXSID7044710 Css NA 0.2281 mg/L 3compartmentss NA 50% Human Human +DTXSID7044710 Css NA 1.874 mg/L 3compartmentss NA 95% Human Human +DTXSID7044710 Css NA 0.1484 mg/L PBTK NA 50% Human Human +DTXSID7044710 Css NA 1.137 mg/L PBTK NA 95% Human Human +DTXSID7044710 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044710 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044710 Vd NA 0.7081 L/kg 1compartment NA NA Rat Human DTXSID7044710 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044710 TK.Half.Life NA 1.703 hours 1compartment NA NA Rat Human -DTXSID7044710 Css NA 0.2463 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044710 Css NA 1.335 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044710 Css NA 0.1546 mg/L PBTK NA 50% Rat Human -DTXSID7044710 Css NA 0.7774 mg/L PBTK NA 95% Rat Human -DTXSID7044714 Clint NA 1.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044714 Fup NA 0.2609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044714 Vd NA 0.2885 L/kg 1compartment NA NA Human Human +DTXSID7044710 TK.Half.Life NA 0.9147 hours 1compartment NA NA Rat Human +DTXSID7044710 Css NA 0.02993 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044710 Css NA 0.1811 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044710 Css NA 0.01897 mg/L PBTK NA 50% Rat Human +DTXSID7044710 Css NA 0.1103 mg/L PBTK NA 95% Rat Human +DTXSID7044712 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044712 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044712 Vd NA 0.9786 L/kg 1compartment NA NA Human Human +DTXSID7044712 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7044712 TK.Half.Life NA 1.044 hours 1compartment NA NA Human Human +DTXSID7044712 Css NA 0.04442 mg/L 3compartmentss NA 50% Human Human +DTXSID7044712 Css NA 0.3551 mg/L 3compartmentss NA 95% Human Human +DTXSID7044712 Css NA 0.03451 mg/L PBTK NA 50% Human Human +DTXSID7044712 Css NA 0.25 mg/L PBTK NA 95% Human Human +DTXSID7044712 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044712 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044712 Vd NA 0.88 L/kg 1compartment NA NA Rat Human +DTXSID7044712 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7044712 TK.Half.Life NA 0.4751 hours 1compartment NA NA Rat Human +DTXSID7044712 Css NA 0.005496 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044712 Css NA 0.03539 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044712 Css NA 0.004331 mg/L PBTK NA 50% Rat Human +DTXSID7044712 Css NA 0.02421 mg/L PBTK NA 95% Rat Human +DTXSID7044714 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044714 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044714 Vd NA 0.3756 L/kg 1compartment NA NA Human Human DTXSID7044714 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044714 TK.Half.Life NA 2.065 hours 1compartment NA NA Human Human -DTXSID7044714 Css NA 0.8614 mg/L 3compartmentss NA 50% Human Human -DTXSID7044714 Css NA 4.016 mg/L 3compartmentss NA 95% Human Human -DTXSID7044714 Css NA 0.5556 mg/L PBTK NA 50% Human Human -DTXSID7044714 Css NA 2.465 mg/L PBTK NA 95% Human Human -DTXSID7044714 Clint NA 1.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044714 Fup NA 0.2609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044714 Vd NA 0.2947 L/kg 1compartment NA NA Rat Human +DTXSID7044714 TK.Half.Life NA 5.307 hours 1compartment NA NA Human Human +DTXSID7044714 Css NA 0.9199 mg/L 3compartmentss NA 50% Human Human +DTXSID7044714 Css NA 4.377 mg/L 3compartmentss NA 95% Human Human +DTXSID7044714 Css NA 0.6414 mg/L PBTK NA 50% Human Human +DTXSID7044714 Css NA 2.695 mg/L PBTK NA 95% Human Human +DTXSID7044714 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044714 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044714 Vd NA 0.3851 L/kg 1compartment NA NA Rat Human DTXSID7044714 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044714 TK.Half.Life NA 1.114 hours 1compartment NA NA Rat Human -DTXSID7044714 Css NA 0.3859 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044714 Css NA 1.335 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044714 Css NA 0.2351 mg/L PBTK NA 50% Rat Human -DTXSID7044714 Css NA 0.7581 mg/L PBTK NA 95% Rat Human -DTXSID7044716 Clint NA 6.626 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044716 Fup NA 0.5486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044716 Vd NA 4.404 L/kg 1compartment NA NA Human Human +DTXSID7044714 TK.Half.Life NA 1.854 hours 1compartment NA NA Rat Human +DTXSID7044714 Css NA 0.004954 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044714 Css NA 0.02473 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044714 Css NA 0.003285 mg/L PBTK NA 50% Rat Human +DTXSID7044714 Css NA 0.01458 mg/L PBTK NA 95% Rat Human +DTXSID7044716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044716 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044716 Vd NA 3.773 L/kg 1compartment NA NA Human Human DTXSID7044716 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044716 TK.Half.Life NA 8.9 hours 1compartment NA NA Human Human -DTXSID7044716 Css NA 0.1309 mg/L 3compartmentss NA 50% Human Human -DTXSID7044716 Css NA 0.9812 mg/L 3compartmentss NA 95% Human Human -DTXSID7044716 Css NA 0.1526 mg/L PBTK NA 50% Human Human -DTXSID7044716 Css NA 0.8852 mg/L PBTK NA 95% Human Human -DTXSID7044716 Clint NA 6.626 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044716 Fup NA 0.5486 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044716 Vd NA 4.104 L/kg 1compartment NA NA Rat Human +DTXSID7044716 TK.Half.Life NA 5.441 hours 1compartment NA NA Human Human +DTXSID7044716 Css NA 0.08003 mg/L 3compartmentss NA 50% Human Human +DTXSID7044716 Css NA 0.5728 mg/L 3compartmentss NA 95% Human Human +DTXSID7044716 Css NA 0.077 mg/L PBTK NA 50% Human Human +DTXSID7044716 Css NA 0.4968 mg/L PBTK NA 95% Human Human +DTXSID7044716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044716 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044716 Vd NA 3.367 L/kg 1compartment NA NA Rat Human DTXSID7044716 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044716 TK.Half.Life NA 3.282 hours 1compartment NA NA Rat Human -DTXSID7044716 Css NA 0.06449 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044716 Css NA 0.3981 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044716 Css NA 0.07506 mg/L PBTK NA 50% Rat Human -DTXSID7044716 Css NA 0.3388 mg/L PBTK NA 95% Rat Human -DTXSID7044718 Clint NA 86.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044718 Fup NA 0.007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044718 Vd NA 0.2109 L/kg 1compartment NA NA Human Human +DTXSID7044716 TK.Half.Life NA 1.933 hours 1compartment NA NA Rat Human +DTXSID7044716 Css NA 0.009678 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044716 Css NA 0.05294 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044716 Css NA 0.009754 mg/L PBTK NA 50% Rat Human +DTXSID7044716 Css NA 0.04769 mg/L PBTK NA 95% Rat Human +DTXSID7044718 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044718 Fup 0.0535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044718 Vd NA 0.2304 L/kg 1compartment NA NA Human Human DTXSID7044718 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044718 TK.Half.Life NA 1.536 hours 1compartment NA NA Human Human -DTXSID7044718 Css NA 1.241 mg/L 3compartmentss NA 50% Human Human -DTXSID7044718 Css NA 12.15 mg/L 3compartmentss NA 95% Human Human -DTXSID7044718 Css NA 0.733 mg/L PBTK NA 50% Human Human -DTXSID7044718 Css NA 7.113 mg/L PBTK NA 95% Human Human -DTXSID7044718 Clint NA 86.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044718 Fup NA 0.007 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044718 Vd NA 0.2023 L/kg 1compartment NA NA Rat Human +DTXSID7044718 TK.Half.Life NA 2.61 hours 1compartment NA NA Human Human +DTXSID7044718 Css NA 1.013 mg/L 3compartmentss NA 50% Human Human +DTXSID7044718 Css NA 7.57 mg/L 3compartmentss NA 95% Human Human +DTXSID7044718 Css NA 0.6108 mg/L PBTK NA 50% Human Human +DTXSID7044718 Css NA 4.472 mg/L PBTK NA 95% Human Human +DTXSID7044718 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044718 Fup 0.0535 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044718 Vd NA 0.2289 L/kg 1compartment NA NA Rat Human DTXSID7044718 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044718 TK.Half.Life NA 0.9752 hours 1compartment NA NA Rat Human -DTXSID7044718 Css NA 0.7091 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044718 Css NA 6.216 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044718 Css NA 0.3886 mg/L PBTK NA 50% Rat Human -DTXSID7044718 Css NA 3.372 mg/L PBTK NA 95% Rat Human -DTXSID7044762 Clint NA 65.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044762 Fup NA 0.0409 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044762 Vd NA 1.776 L/kg 1compartment NA NA Human Human -DTXSID7044762 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044762 TK.Half.Life NA 4.481 hours 1compartment NA NA Human Human -DTXSID7044762 Css NA 0.2864 mg/L 3compartmentss NA 50% Human Human -DTXSID7044762 Css NA 2.334 mg/L 3compartmentss NA 95% Human Human -DTXSID7044762 Css NA 0.1846 mg/L PBTK NA 50% Human Human -DTXSID7044762 Css NA 1.462 mg/L PBTK NA 95% Human Human -DTXSID7044762 Clint NA 65.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044762 Fup NA 0.0409 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044762 Vd NA 1.328 L/kg 1compartment NA NA Rat Human -DTXSID7044762 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044762 TK.Half.Life NA 1.571 hours 1compartment NA NA Rat Human -DTXSID7044762 Css NA 0.1587 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044762 Css NA 1.14 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044762 Css NA 0.09606 mg/L PBTK NA 50% Rat Human -DTXSID7044762 Css NA 0.6612 mg/L PBTK NA 95% Rat Human -DTXSID7044768 Clint NA 0.572 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044768 Fup NA 0.4091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044768 Vd NA 0.4031 L/kg 1compartment NA NA Human Human +DTXSID7044718 TK.Half.Life NA 1.617 hours 1compartment NA NA Rat Human +DTXSID7044718 Css NA 0.01048 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044718 Css NA 0.06737 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044718 Css NA 0.005884 mg/L PBTK NA 50% Rat Human +DTXSID7044718 Css NA 0.03704 mg/L PBTK NA 95% Rat Human +DTXSID7044762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044762 Fup 0.0784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044762 Vd NA 3.053 L/kg 1compartment NA NA Human Human +DTXSID7044762 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7044762 TK.Half.Life NA 42.01 hours 1compartment NA NA Human Human +DTXSID7044762 Css NA 1.599 mg/L 3compartmentss NA 50% Human Human +DTXSID7044762 Css NA 10.19 mg/L 3compartmentss NA 95% Human Human +DTXSID7044762 Css NA 1.117 mg/L PBTK NA 50% Human Human +DTXSID7044762 Css NA 6.832 mg/L PBTK NA 95% Human Human +DTXSID7044762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044762 Fup 0.0784 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044762 Vd NA 2.29 L/kg 1compartment NA NA Rat Human +DTXSID7044762 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7044762 TK.Half.Life NA 6.466 hours 1compartment NA NA Rat Human +DTXSID7044762 Css NA 0.2065 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044762 Css NA 1.118 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044762 Css NA 0.1418 mg/L PBTK NA 50% Rat Human +DTXSID7044762 Css NA 0.7433 mg/L PBTK NA 95% Rat Human +DTXSID7044764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044764 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044764 Vd NA 2.422 L/kg 1compartment NA NA Human Human +DTXSID7044764 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7044764 TK.Half.Life NA 9.474 hours 1compartment NA NA Human Human +DTXSID7044764 Css NA 0.4267 mg/L 3compartmentss NA 50% Human Human +DTXSID7044764 Css NA 2.84 mg/L 3compartmentss NA 95% Human Human +DTXSID7044764 Css NA 0.2931 mg/L PBTK NA 50% Human Human +DTXSID7044764 Css NA 1.875 mg/L PBTK NA 95% Human Human +DTXSID7044764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044764 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044764 Vd NA 1.828 L/kg 1compartment NA NA Rat Human +DTXSID7044764 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7044764 TK.Half.Life NA 2.616 hours 1compartment NA NA Rat Human +DTXSID7044764 Css NA 0.05467 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044764 Css NA 0.2984 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044764 Css NA 0.03722 mg/L PBTK NA 50% Rat Human +DTXSID7044764 Css NA 0.1939 mg/L PBTK NA 95% Rat Human +DTXSID7044768 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044768 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044768 Vd NA 0.4533 L/kg 1compartment NA NA Human Human DTXSID7044768 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044768 TK.Half.Life NA 3.353 hours 1compartment NA NA Human Human -DTXSID7044768 Css NA 0.9628 mg/L 3compartmentss NA 50% Human Human -DTXSID7044768 Css NA 4.462 mg/L 3compartmentss NA 95% Human Human -DTXSID7044768 Css NA 0.6669 mg/L PBTK NA 50% Human Human -DTXSID7044768 Css NA 2.771 mg/L PBTK NA 95% Human Human -DTXSID7044768 Clint NA 0.572 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044768 Fup NA 0.4091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044768 Vd NA 0.4114 L/kg 1compartment NA NA Rat Human +DTXSID7044768 TK.Half.Life NA 5.7 hours 1compartment NA NA Human Human +DTXSID7044768 Css NA 1.456 mg/L 3compartmentss NA 50% Human Human +DTXSID7044768 Css NA 7.588 mg/L 3compartmentss NA 95% Human Human +DTXSID7044768 Css NA 1.05 mg/L PBTK NA 50% Human Human +DTXSID7044768 Css NA 4.698 mg/L PBTK NA 95% Human Human +DTXSID7044768 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044768 Fup 0.515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044768 Vd NA 0.4639 L/kg 1compartment NA NA Rat Human DTXSID7044768 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044768 TK.Half.Life NA 1.534 hours 1compartment NA NA Rat Human -DTXSID7044768 Css NA 0.3536 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044768 Css NA 1.374 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044768 Css NA 0.2332 mg/L PBTK NA 50% Rat Human -DTXSID7044768 Css NA 0.7935 mg/L PBTK NA 95% Rat Human -DTXSID7044841 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044841 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044841 Vd NA 3.449 L/kg 1compartment NA NA Human Human -DTXSID7044841 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID7044841 TK.Half.Life NA 34150 hours 1compartment NA NA Human Human -DTXSID7044841 Css NA 1114 mg/L 3compartmentss NA 50% Human Human -DTXSID7044841 Css NA 3076 mg/L 3compartmentss NA 95% Human Human -DTXSID7044841 Css NA 797.8 mg/L PBTK NA 50% Human Human -DTXSID7044841 Css NA 2020 mg/L PBTK NA 95% Human Human -DTXSID7044841 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044841 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044841 Vd NA 2.595 L/kg 1compartment NA NA Rat Human -DTXSID7044841 Days.Css NA 2419 Days PBTK NA NA Rat Human -DTXSID7044841 TK.Half.Life NA 2224 hours 1compartment NA NA Rat Human -DTXSID7044841 Css NA 300.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044841 Css NA 684.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044841 Css NA 206.3 mg/L PBTK NA 50% Rat Human -DTXSID7044841 Css NA 418.8 mg/L PBTK NA 95% Rat Human +DTXSID7044768 TK.Half.Life NA 1.986 hours 1compartment NA NA Rat Human +DTXSID7044768 Css NA 0.09188 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044768 Css NA 0.4299 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044768 Css NA 0.0652 mg/L PBTK NA 50% Rat Human +DTXSID7044768 Css NA 0.2568 mg/L PBTK NA 95% Rat Human +DTXSID7044841 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044841 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044841 Vd NA 4.392 L/kg 1compartment NA NA Human Human +DTXSID7044841 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID7044841 TK.Half.Life NA 105.9 hours 1compartment NA NA Human Human +DTXSID7044841 Css NA 2.634 mg/L 3compartmentss NA 50% Human Human +DTXSID7044841 Css NA 17.23 mg/L 3compartmentss NA 95% Human Human +DTXSID7044841 Css NA 2.018 mg/L PBTK NA 50% Human Human +DTXSID7044841 Css NA 12.6 mg/L PBTK NA 95% Human Human +DTXSID7044841 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044841 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044841 Vd NA 3.337 L/kg 1compartment NA NA Rat Human +DTXSID7044841 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID7044841 TK.Half.Life NA 15.36 hours 1compartment NA NA Rat Human +DTXSID7044841 Css NA 0.3351 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044841 Css NA 1.932 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044841 Css NA 0.2583 mg/L PBTK NA 50% Rat Human +DTXSID7044841 Css NA 1.422 mg/L PBTK NA 95% Rat Human DTXSID7044843 Clint NA 1.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7044843 Fup NA 0.0022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044843 Vd NA 2.343 L/kg 1compartment NA NA Human Human -DTXSID7044843 Days.Css NA 527 Days PBTK NA NA Human Human -DTXSID7044843 TK.Half.Life NA 1991 hours 1compartment NA NA Human Human -DTXSID7044843 Css NA 130.8 mg/L 3compartmentss NA 50% Human Human -DTXSID7044843 Css NA 924.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7044843 Css NA 87.69 mg/L PBTK NA 50% Human Human -DTXSID7044843 Css NA 555.4 mg/L PBTK NA 95% Human Human +DTXSID7044843 Vd NA 7.796 L/kg 1compartment NA NA Human Human +DTXSID7044843 Days.Css NA 1167 Days PBTK NA NA Human Human +DTXSID7044843 TK.Half.Life NA 4338 hours 1compartment NA NA Human Human +DTXSID7044843 Css NA 39.28 mg/L 3compartmentss NA 50% Human Human +DTXSID7044843 Css NA 225.7 mg/L 3compartmentss NA 95% Human Human +DTXSID7044843 Css NA 39.53 mg/L PBTK NA 50% Human Human +DTXSID7044843 Css NA 219.4 mg/L PBTK NA 95% Human Human DTXSID7044843 Clint NA 1.196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7044843 Fup NA 0.0022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044843 Vd NA 1.762 L/kg 1compartment NA NA Rat Human -DTXSID7044843 Days.Css NA 213 Days PBTK NA NA Rat Human -DTXSID7044843 TK.Half.Life NA 797.7 hours 1compartment NA NA Rat Human -DTXSID7044843 Css NA 57.81 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044843 Css NA 331.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044843 Css NA 36.52 mg/L PBTK NA 50% Rat Human -DTXSID7044843 Css NA 186.5 mg/L PBTK NA 95% Rat Human -DTXSID7044845 Clint NA 6.791 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044845 Fup NA 0.4849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044845 Vd NA 0.9994 L/kg 1compartment NA NA Human Human +DTXSID7044843 Vd NA 6.069 L/kg 1compartment NA NA Rat Human +DTXSID7044843 Days.Css NA 637 Days PBTK NA NA Rat Human +DTXSID7044843 TK.Half.Life NA 664.6 hours 1compartment NA NA Rat Human +DTXSID7044843 Css NA 1.375 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044843 Css NA 8.957 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044843 Css NA 1.386 mg/L PBTK NA 50% Rat Human +DTXSID7044843 Css NA 8.818 mg/L PBTK NA 95% Rat Human +DTXSID7044845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044845 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044845 Vd NA 2.142 L/kg 1compartment NA NA Human Human DTXSID7044845 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044845 TK.Half.Life NA 1.703 hours 1compartment NA NA Human Human -DTXSID7044845 Css NA 0.1284 mg/L 3compartmentss NA 50% Human Human -DTXSID7044845 Css NA 0.9746 mg/L 3compartmentss NA 95% Human Human -DTXSID7044845 Css NA 0.1013 mg/L PBTK NA 50% Human Human -DTXSID7044845 Css NA 0.6601 mg/L PBTK NA 95% Human Human -DTXSID7044845 Clint NA 6.791 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044845 Fup NA 0.4849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044845 Vd NA 0.8908 L/kg 1compartment NA NA Rat Human +DTXSID7044845 TK.Half.Life NA 5.18 hours 1compartment NA NA Human Human +DTXSID7044845 Css NA 0.1994 mg/L 3compartmentss NA 50% Human Human +DTXSID7044845 Css NA 1.327 mg/L 3compartmentss NA 95% Human Human +DTXSID7044845 Css NA 0.142 mg/L PBTK NA 50% Human Human +DTXSID7044845 Css NA 0.8832 mg/L PBTK NA 95% Human Human +DTXSID7044845 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044845 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044845 Vd NA 1.633 L/kg 1compartment NA NA Rat Human DTXSID7044845 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044845 TK.Half.Life NA 0.8101 hours 1compartment NA NA Rat Human -DTXSID7044845 Css NA 0.06486 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044845 Css NA 0.3682 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044845 Css NA 0.04968 mg/L PBTK NA 50% Rat Human -DTXSID7044845 Css NA 0.2355 mg/L PBTK NA 95% Rat Human -DTXSID7044847 Clint NA 1568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044847 Fup NA 0.1675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044847 Vd NA 2.644 L/kg 1compartment NA NA Human Human +DTXSID7044845 TK.Half.Life NA 1.653 hours 1compartment NA NA Rat Human +DTXSID7044845 Css NA 0.02522 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044845 Css NA 0.1258 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044845 Css NA 0.01784 mg/L PBTK NA 50% Rat Human +DTXSID7044845 Css NA 0.08622 mg/L PBTK NA 95% Rat Human +DTXSID7044847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044847 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044847 Vd NA 0.7467 L/kg 1compartment NA NA Human Human DTXSID7044847 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044847 TK.Half.Life NA 2.183 hours 1compartment NA NA Human Human -DTXSID7044847 Css NA 0.004977 mg/L 3compartmentss NA 50% Human Human -DTXSID7044847 Css NA 0.0325 mg/L 3compartmentss NA 95% Human Human -DTXSID7044847 Css NA 0.00353 mg/L PBTK NA 50% Human Human -DTXSID7044847 Css NA 0.02223 mg/L PBTK NA 95% Human Human -DTXSID7044847 Clint NA 1568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044847 Fup NA 0.1675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044847 Vd NA 2.002 L/kg 1compartment NA NA Rat Human +DTXSID7044847 TK.Half.Life NA 1.054 hours 1compartment NA NA Human Human +DTXSID7044847 Css NA 0.07852 mg/L 3compartmentss NA 50% Human Human +DTXSID7044847 Css NA 0.5799 mg/L 3compartmentss NA 95% Human Human +DTXSID7044847 Css NA 0.05573 mg/L PBTK NA 50% Human Human +DTXSID7044847 Css NA 0.3836 mg/L PBTK NA 95% Human Human +DTXSID7044847 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044847 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044847 Vd NA 0.667 L/kg 1compartment NA NA Rat Human DTXSID7044847 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044847 TK.Half.Life NA 0.7077 hours 1compartment NA NA Rat Human -DTXSID7044847 Css NA 0.002736 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044847 Css NA 0.015 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044847 Css NA 0.001868 mg/L PBTK NA 50% Rat Human -DTXSID7044847 Css NA 0.009797 mg/L PBTK NA 95% Rat Human +DTXSID7044847 TK.Half.Life NA 0.5016 hours 1compartment NA NA Rat Human +DTXSID7044847 Css NA 0.009948 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044847 Css NA 0.05695 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044847 Css NA 0.00702 mg/L PBTK NA 50% Rat Human +DTXSID7044847 Css NA 0.03728 mg/L PBTK NA 95% Rat Human DTXSID7044849 Clint NA 0.1859 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7044849 Fup NA 0.9647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044849 Vd NA 0.6852 L/kg 1compartment NA NA Human Human +DTXSID7044849 Vd NA 0.8908 L/kg 1compartment NA NA Human Human DTXSID7044849 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044849 TK.Half.Life NA 3.535 hours 1compartment NA NA Human Human -DTXSID7044849 Css NA 0.6924 mg/L 3compartmentss NA 50% Human Human -DTXSID7044849 Css NA 3.862 mg/L 3compartmentss NA 95% Human Human -DTXSID7044849 Css NA 0.5496 mg/L PBTK NA 50% Human Human -DTXSID7044849 Css NA 2.484 mg/L PBTK NA 95% Human Human +DTXSID7044849 TK.Half.Life NA 4.6 hours 1compartment NA NA Human Human +DTXSID7044849 Css NA 0.5515 mg/L 3compartmentss NA 50% Human Human +DTXSID7044849 Css NA 3.175 mg/L 3compartmentss NA 95% Human Human +DTXSID7044849 Css NA 0.4683 mg/L PBTK NA 50% Human Human +DTXSID7044849 Css NA 2.099 mg/L PBTK NA 95% Human Human DTXSID7044849 Clint NA 0.1859 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7044849 Fup NA 0.9647 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044849 Vd NA 0.7163 L/kg 1compartment NA NA Rat Human +DTXSID7044849 Vd NA 0.922 L/kg 1compartment NA NA Rat Human DTXSID7044849 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044849 TK.Half.Life NA 1.427 hours 1compartment NA NA Rat Human -DTXSID7044849 Css NA 0.205 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044849 Css NA 1.145 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044849 Css NA 0.1579 mg/L PBTK NA 50% Rat Human -DTXSID7044849 Css NA 0.6786 mg/L PBTK NA 95% Rat Human -DTXSID7044893 Clint NA 1.015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044893 Fup NA 0.0111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044893 Vd NA 7.857 L/kg 1compartment NA NA Human Human -DTXSID7044893 Days.Css NA 479 Days PBTK NA NA Human Human -DTXSID7044893 TK.Half.Life NA 1845 hours 1compartment NA NA Human Human -DTXSID7044893 Css NA 24.25 mg/L 3compartmentss NA 50% Human Human -DTXSID7044893 Css NA 172.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7044893 Css NA 23.86 mg/L PBTK NA 50% Human Human -DTXSID7044893 Css NA 126.1 mg/L PBTK NA 95% Human Human -DTXSID7044893 Clint NA 1.015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044893 Fup NA 0.0111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044893 Vd NA 6.134 L/kg 1compartment NA NA Rat Human -DTXSID7044893 Days.Css NA 218 Days PBTK NA NA Rat Human -DTXSID7044893 TK.Half.Life NA 527.9 hours 1compartment NA NA Rat Human -DTXSID7044893 Css NA 10.64 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044893 Css NA 64.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044893 Css NA 10.44 mg/L PBTK NA 50% Rat Human -DTXSID7044893 Css NA 42.73 mg/L PBTK NA 95% Rat Human -DTXSID7044895 Clint NA 86.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044895 Fup NA 0.0953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044895 Vd NA 1.619 L/kg 1compartment NA NA Human Human +DTXSID7044849 TK.Half.Life NA 1.838 hours 1compartment NA NA Rat Human +DTXSID7044849 Css NA 0.01208 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044849 Css NA 0.08867 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044849 Css NA 0.00984 mg/L PBTK NA 50% Rat Human +DTXSID7044849 Css NA 0.05872 mg/L PBTK NA 95% Rat Human +DTXSID7044893 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044893 Fup 0.0188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044893 Vd NA 2.289 L/kg 1compartment NA NA Human Human +DTXSID7044893 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7044893 TK.Half.Life NA 26.55 hours 1compartment NA NA Human Human +DTXSID7044893 Css NA 1.636 mg/L 3compartmentss NA 50% Human Human +DTXSID7044893 Css NA 12.76 mg/L 3compartmentss NA 95% Human Human +DTXSID7044893 Css NA 1.081 mg/L PBTK NA 50% Human Human +DTXSID7044893 Css NA 8.148 mg/L PBTK NA 95% Human Human +DTXSID7044893 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044893 Fup 0.0188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044893 Vd NA 1.711 L/kg 1compartment NA NA Rat Human +DTXSID7044893 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7044893 TK.Half.Life NA 7.506 hours 1compartment NA NA Rat Human +DTXSID7044893 Css NA 0.2117 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044893 Css NA 1.335 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044893 Css NA 0.1382 mg/L PBTK NA 50% Rat Human +DTXSID7044893 Css NA 0.826 mg/L PBTK NA 95% Rat Human +DTXSID7044895 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044895 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044895 Vd NA 2.326 L/kg 1compartment NA NA Human Human DTXSID7044895 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044895 TK.Half.Life NA 2.255 hours 1compartment NA NA Human Human -DTXSID7044895 Css NA 0.08798 mg/L 3compartmentss NA 50% Human Human -DTXSID7044895 Css NA 0.6811 mg/L 3compartmentss NA 95% Human Human -DTXSID7044895 Css NA 0.05859 mg/L PBTK NA 50% Human Human -DTXSID7044895 Css NA 0.4369 mg/L PBTK NA 95% Human Human -DTXSID7044895 Clint NA 86.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044895 Fup NA 0.0953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044895 Vd NA 1.233 L/kg 1compartment NA NA Rat Human +DTXSID7044895 TK.Half.Life NA 8.494 hours 1compartment NA NA Human Human +DTXSID7044895 Css NA 0.3926 mg/L 3compartmentss NA 50% Human Human +DTXSID7044895 Css NA 2.704 mg/L 3compartmentss NA 95% Human Human +DTXSID7044895 Css NA 0.2708 mg/L PBTK NA 50% Human Human +DTXSID7044895 Css NA 1.76 mg/L PBTK NA 95% Human Human +DTXSID7044895 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044895 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044895 Vd NA 1.757 L/kg 1compartment NA NA Rat Human DTXSID7044895 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044895 TK.Half.Life NA 0.8085 hours 1compartment NA NA Rat Human -DTXSID7044895 Css NA 0.05002 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044895 Css NA 0.3239 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044895 Css NA 0.03136 mg/L PBTK NA 50% Rat Human -DTXSID7044895 Css NA 0.199 mg/L PBTK NA 95% Rat Human -DTXSID7044897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044897 Fup NA 0.9682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044897 Vd NA 0.8607 L/kg 1compartment NA NA Human Human +DTXSID7044895 TK.Half.Life NA 2.461 hours 1compartment NA NA Rat Human +DTXSID7044895 Css NA 0.05062 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044895 Css NA 0.276 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044895 Css NA 0.03432 mg/L PBTK NA 50% Rat Human +DTXSID7044895 Css NA 0.1799 mg/L PBTK NA 95% Rat Human +DTXSID7044897 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044897 Fup 0.749 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044897 Vd NA 0.7528 L/kg 1compartment NA NA Human Human DTXSID7044897 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044897 TK.Half.Life NA 5.771 hours 1compartment NA NA Human Human -DTXSID7044897 Css NA 0.878 mg/L 3compartmentss NA 50% Human Human -DTXSID7044897 Css NA 4.825 mg/L 3compartmentss NA 95% Human Human -DTXSID7044897 Css NA 0.744 mg/L PBTK NA 50% Human Human -DTXSID7044897 Css NA 3.232 mg/L PBTK NA 95% Human Human -DTXSID7044897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044897 Fup NA 0.9682 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044897 Vd NA 0.884 L/kg 1compartment NA NA Rat Human +DTXSID7044897 TK.Half.Life NA 6.527 hours 1compartment NA NA Human Human +DTXSID7044897 Css NA 0.876 mg/L 3compartmentss NA 50% Human Human +DTXSID7044897 Css NA 5.671 mg/L 3compartmentss NA 95% Human Human +DTXSID7044897 Css NA 0.722 mg/L PBTK NA 50% Human Human +DTXSID7044897 Css NA 3.682 mg/L PBTK NA 95% Human Human +DTXSID7044897 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044897 Fup 0.749 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044897 Vd NA 0.7692 L/kg 1compartment NA NA Rat Human DTXSID7044897 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044897 TK.Half.Life NA 2.015 hours 1compartment NA NA Rat Human -DTXSID7044897 Css NA 0.221 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044897 Css NA 1.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044897 Css NA 0.1839 mg/L PBTK NA 50% Rat Human -DTXSID7044897 Css NA 0.7413 mg/L PBTK NA 95% Rat Human -DTXSID7044899 Clint NA 32.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044899 Fup NA 0.7589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044899 Vd NA 1.156 L/kg 1compartment NA NA Human Human -DTXSID7044899 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044899 TK.Half.Life NA 0.8121 hours 1compartment NA NA Human Human -DTXSID7044899 Css NA 0.01925 mg/L 3compartmentss NA 50% Human Human -DTXSID7044899 Css NA 0.2086 mg/L 3compartmentss NA 95% Human Human -DTXSID7044899 Css NA 0.01668 mg/L PBTK NA 50% Human Human -DTXSID7044899 Css NA 0.1517 mg/L PBTK NA 95% Human Human -DTXSID7044899 Clint NA 32.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044899 Fup NA 0.7589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044899 Vd NA 1.15 L/kg 1compartment NA NA Rat Human +DTXSID7044897 TK.Half.Life NA 2.266 hours 1compartment NA NA Rat Human +DTXSID7044897 Css NA 0.01661 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044897 Css NA 0.1336 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044897 Css NA 0.01324 mg/L PBTK NA 50% Rat Human +DTXSID7044897 Css NA 0.08523 mg/L PBTK NA 95% Rat Human +DTXSID7044899 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044899 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044899 Vd NA 1.093 L/kg 1compartment NA NA Human Human +DTXSID7044899 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7044899 TK.Half.Life NA 10.08 hours 1compartment NA NA Human Human +DTXSID7044899 Css NA 0.9904 mg/L 3compartmentss NA 50% Human Human +DTXSID7044899 Css NA 6.627 mg/L 3compartmentss NA 95% Human Human +DTXSID7044899 Css NA 0.8583 mg/L PBTK NA 50% Human Human +DTXSID7044899 Css NA 4.319 mg/L PBTK NA 95% Human Human +DTXSID7044899 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044899 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044899 Vd NA 1.088 L/kg 1compartment NA NA Rat Human DTXSID7044899 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044899 TK.Half.Life NA 0.3838 hours 1compartment NA NA Rat Human -DTXSID7044899 Css NA 0.009821 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044899 Css NA 0.09472 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044899 Css NA 0.008426 mg/L PBTK NA 50% Rat Human -DTXSID7044899 Css NA 0.06455 mg/L PBTK NA 95% Rat Human +DTXSID7044899 TK.Half.Life NA 3.388 hours 1compartment NA NA Rat Human +DTXSID7044899 Css NA 0.05878 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044899 Css NA 0.4008 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044899 Css NA 0.05142 mg/L PBTK NA 50% Rat Human +DTXSID7044899 Css NA 0.2502 mg/L PBTK NA 95% Rat Human DTXSID7044922 Clint 0.1559 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID7044922 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID7044922 Vd NA 0.8227 L/kg 1compartment NA NA Human Human +DTXSID7044922 Vd NA 0.7859 L/kg 1compartment NA NA Human Human DTXSID7044922 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044922 TK.Half.Life NA 4.258 hours 1compartment NA NA Human Human -DTXSID7044922 Css NA 0.6111 mg/L 3compartmentss NA 50% Human Human -DTXSID7044922 Css NA 1.834 mg/L 3compartmentss NA 95% Human Human -DTXSID7044922 Css NA 0.522 mg/L PBTK NA 50% Human Human -DTXSID7044922 Css NA 1.358 mg/L PBTK NA 95% Human Human +DTXSID7044922 TK.Half.Life NA 4.063 hours 1compartment NA NA Human Human +DTXSID7044922 Css NA 0.5968 mg/L 3compartmentss NA 50% Human Human +DTXSID7044922 Css NA 1.766 mg/L 3compartmentss NA 95% Human Human +DTXSID7044922 Css NA 0.5059 mg/L PBTK NA 50% Human Human +DTXSID7044922 Css NA 1.314 mg/L PBTK NA 95% Human Human DTXSID7044922 Clint 0.1559 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID7044922 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID7044922 Vd NA 0.8545 L/kg 1compartment NA NA Rat Human +DTXSID7044922 Vd NA 0.8228 L/kg 1compartment NA NA Rat Human DTXSID7044922 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044922 TK.Half.Life NA 1.678 hours 1compartment NA NA Rat Human -DTXSID7044922 Css NA 0.1778 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044922 Css NA 0.4488 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044922 Css NA 0.1496 mg/L PBTK NA 50% Rat Human -DTXSID7044922 Css NA 0.3092 mg/L PBTK NA 95% Rat Human -DTXSID7044926 Clint NA 72.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044926 Fup NA 0.2869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044926 Vd NA 3.719 L/kg 1compartment NA NA Human Human +DTXSID7044922 TK.Half.Life NA 1.615 hours 1compartment NA NA Rat Human +DTXSID7044922 Css NA 0.04067 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044922 Css NA 0.103 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044922 Css NA 0.03507 mg/L PBTK NA 50% Rat Human +DTXSID7044922 Css NA 0.0726 mg/L PBTK NA 95% Rat Human +DTXSID7044926 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044926 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044926 Vd NA 3.636 L/kg 1compartment NA NA Human Human DTXSID7044926 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044926 TK.Half.Life NA 1.685 hours 1compartment NA NA Human Human -DTXSID7044926 Css NA 0.005673 mg/L 3compartmentss NA 50% Human Human -DTXSID7044926 Css NA 0.05245 mg/L 3compartmentss NA 95% Human Human -DTXSID7044926 Css NA 0.008074 mg/L PBTK NA 50% Human Human -DTXSID7044926 Css NA 0.0567 mg/L PBTK NA 95% Human Human -DTXSID7044926 Clint NA 72.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044926 Fup NA 0.2869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044926 Vd NA 3.679 L/kg 1compartment NA NA Rat Human +DTXSID7044926 TK.Half.Life NA 2.419 hours 1compartment NA NA Human Human +DTXSID7044926 Css NA 0.0179 mg/L 3compartmentss NA 50% Human Human +DTXSID7044926 Css NA 0.1808 mg/L 3compartmentss NA 95% Human Human +DTXSID7044926 Css NA 0.02557 mg/L PBTK NA 50% Human Human +DTXSID7044926 Css NA 0.1884 mg/L PBTK NA 95% Human Human +DTXSID7044926 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044926 Fup 0.323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044926 Vd NA 3.6 L/kg 1compartment NA NA Rat Human DTXSID7044926 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044926 TK.Half.Life NA 0.8054 hours 1compartment NA NA Rat Human -DTXSID7044926 Css NA 0.002952 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044926 Css NA 0.02293 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044926 Css NA 0.004317 mg/L PBTK NA 50% Rat Human -DTXSID7044926 Css NA 0.02504 mg/L PBTK NA 95% Rat Human -DTXSID7044928 Clint NA 200.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044928 Fup NA 0.4706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044928 Vd NA 2.334 L/kg 1compartment NA NA Human Human -DTXSID7044928 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044928 TK.Half.Life NA 1.345 hours 1compartment NA NA Human Human -DTXSID7044928 Css NA 0.003894 mg/L 3compartmentss NA 50% Human Human -DTXSID7044928 Css NA 0.03783 mg/L 3compartmentss NA 95% Human Human -DTXSID7044928 Css NA 0.00381 mg/L PBTK NA 50% Human Human -DTXSID7044928 Css NA 0.02963 mg/L PBTK NA 95% Human Human -DTXSID7044928 Clint NA 200.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044928 Fup NA 0.4706 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044928 Vd NA 2.391 L/kg 1compartment NA NA Rat Human -DTXSID7044928 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044928 TK.Half.Life NA 0.62 hours 1compartment NA NA Rat Human -DTXSID7044928 Css NA 0.002053 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044928 Css NA 0.01707 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044928 Css NA 0.001971 mg/L PBTK NA 50% Rat Human -DTXSID7044928 Css NA 0.01345 mg/L PBTK NA 95% Rat Human -DTXSID7044970 Clint NA 0.5065 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044970 Fup NA 0.1563 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044970 Vd NA 1.692 L/kg 1compartment NA NA Human Human -DTXSID7044970 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID7044970 TK.Half.Life NA 52.95 hours 1compartment NA NA Human Human -DTXSID7044970 Css NA 3.92 mg/L 3compartmentss NA 50% Human Human -DTXSID7044970 Css NA 16.36 mg/L 3compartmentss NA 95% Human Human -DTXSID7044970 Css NA 2.754 mg/L PBTK NA 50% Human Human -DTXSID7044970 Css NA 10.33 mg/L PBTK NA 95% Human Human -DTXSID7044970 Clint NA 0.5065 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044970 Fup NA 0.1563 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044970 Vd NA 1.308 L/kg 1compartment NA NA Rat Human -DTXSID7044970 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7044970 TK.Half.Life NA 14.01 hours 1compartment NA NA Rat Human -DTXSID7044970 Css NA 1.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044970 Css NA 4.859 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044970 Css NA 0.9746 mg/L PBTK NA 50% Rat Human -DTXSID7044970 Css NA 2.833 mg/L PBTK NA 95% Rat Human -DTXSID7044972 Clint NA 1.455 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044972 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044972 Vd NA 3.059 L/kg 1compartment NA NA Human Human -DTXSID7044972 Days.Css NA 217 Days PBTK NA NA Human Human -DTXSID7044972 TK.Half.Life NA 872.5 hours 1compartment NA NA Human Human -DTXSID7044972 Css NA 36.49 mg/L 3compartmentss NA 50% Human Human -DTXSID7044972 Css NA 202.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7044972 Css NA 25.16 mg/L PBTK NA 50% Human Human -DTXSID7044972 Css NA 133.9 mg/L PBTK NA 95% Human Human -DTXSID7044972 Clint NA 1.455 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044972 Fup NA 0.0292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044972 Vd NA 2.291 L/kg 1compartment NA NA Rat Human -DTXSID7044972 Days.Css NA 111 Days PBTK NA NA Rat Human -DTXSID7044972 TK.Half.Life NA 117.5 hours 1compartment NA NA Rat Human -DTXSID7044972 Css NA 19.26 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044972 Css NA 75.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044972 Css NA 12.75 mg/L PBTK NA 50% Rat Human -DTXSID7044972 Css NA 47.97 mg/L PBTK NA 95% Rat Human -DTXSID7044974 Clint NA 1.516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044974 Fup NA 0.5597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044974 Vd NA 1.175 L/kg 1compartment NA NA Human Human -DTXSID7044974 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044974 TK.Half.Life NA 4.229 hours 1compartment NA NA Human Human -DTXSID7044974 Css NA 0.3488 mg/L 3compartmentss NA 50% Human Human -DTXSID7044974 Css NA 2.882 mg/L 3compartmentss NA 95% Human Human -DTXSID7044974 Css NA 0.3016 mg/L PBTK NA 50% Human Human -DTXSID7044974 Css NA 1.88 mg/L PBTK NA 95% Human Human -DTXSID7044974 Clint NA 1.516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044974 Fup NA 0.5597 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044974 Vd NA 1.162 L/kg 1compartment NA NA Rat Human +DTXSID7044926 TK.Half.Life NA 1.3 hours 1compartment NA NA Rat Human +DTXSID7044926 Css NA 0.002145 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044926 Css NA 0.01722 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044926 Css NA 0.003222 mg/L PBTK NA 50% Rat Human +DTXSID7044926 Css NA 0.01875 mg/L PBTK NA 95% Rat Human +DTXSID7044970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044970 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044970 Vd NA 2.961 L/kg 1compartment NA NA Human Human +DTXSID7044970 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7044970 TK.Half.Life NA 20.06 hours 1compartment NA NA Human Human +DTXSID7044970 Css NA 0.7365 mg/L 3compartmentss NA 50% Human Human +DTXSID7044970 Css NA 4.732 mg/L 3compartmentss NA 95% Human Human +DTXSID7044970 Css NA 0.5185 mg/L PBTK NA 50% Human Human +DTXSID7044970 Css NA 3.241 mg/L PBTK NA 95% Human Human +DTXSID7044970 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044970 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044970 Vd NA 2.228 L/kg 1compartment NA NA Rat Human +DTXSID7044970 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7044970 TK.Half.Life NA 3.66 hours 1compartment NA NA Rat Human +DTXSID7044970 Css NA 0.09504 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044970 Css NA 0.4843 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044970 Css NA 0.06629 mg/L PBTK NA 50% Rat Human +DTXSID7044970 Css NA 0.3291 mg/L PBTK NA 95% Rat Human +DTXSID7044972 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044972 Fup 0.0125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044972 Vd NA 6.856 L/kg 1compartment NA NA Human Human +DTXSID7044972 Days.Css NA 40 Days PBTK NA NA Human Human +DTXSID7044972 TK.Half.Life NA 206.1 hours 1compartment NA NA Human Human +DTXSID7044972 Css NA 2.532 mg/L 3compartmentss NA 50% Human Human +DTXSID7044972 Css NA 14.54 mg/L 3compartmentss NA 95% Human Human +DTXSID7044972 Css NA 2.401 mg/L PBTK NA 50% Human Human +DTXSID7044972 Css NA 13.37 mg/L PBTK NA 95% Human Human +DTXSID7044972 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044972 Fup 0.0125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044972 Vd NA 5.307 L/kg 1compartment NA NA Rat Human +DTXSID7044972 Days.Css NA 24 Days PBTK NA NA Rat Human +DTXSID7044972 TK.Half.Life NA 28.43 hours 1compartment NA NA Rat Human +DTXSID7044972 Css NA 0.3246 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044972 Css NA 1.584 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044972 Css NA 0.3087 mg/L PBTK NA 50% Rat Human +DTXSID7044972 Css NA 1.59 mg/L PBTK NA 95% Rat Human +DTXSID7044974 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044974 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044974 Vd NA 0.8087 L/kg 1compartment NA NA Human Human +DTXSID7044974 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7044974 TK.Half.Life NA 15.76 hours 1compartment NA NA Human Human +DTXSID7044974 Css NA 1.809 mg/L 3compartmentss NA 50% Human Human +DTXSID7044974 Css NA 7.676 mg/L 3compartmentss NA 95% Human Human +DTXSID7044974 Css NA 1.365 mg/L PBTK NA 50% Human Human +DTXSID7044974 Css NA 4.944 mg/L PBTK NA 95% Human Human +DTXSID7044974 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044974 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044974 Vd NA 0.7969 L/kg 1compartment NA NA Rat Human DTXSID7044974 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044974 TK.Half.Life NA 2.155 hours 1compartment NA NA Rat Human -DTXSID7044974 Css NA 0.1446 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044974 Css NA 1.066 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044974 Css NA 0.1218 mg/L PBTK NA 50% Rat Human -DTXSID7044974 Css NA 0.6418 mg/L PBTK NA 95% Rat Human -DTXSID7044976 Clint NA 13.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044976 Fup NA 0.299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044976 Vd NA 1.475 L/kg 1compartment NA NA Human Human +DTXSID7044974 TK.Half.Life NA 5.291 hours 1compartment NA NA Rat Human +DTXSID7044974 Css NA 0.03251 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044974 Css NA 0.2026 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044974 Css NA 0.02383 mg/L PBTK NA 50% Rat Human +DTXSID7044974 Css NA 0.1324 mg/L PBTK NA 95% Rat Human +DTXSID7044976 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044976 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7044976 Vd NA 2.358 L/kg 1compartment NA NA Human Human DTXSID7044976 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7044976 TK.Half.Life NA 2.397 hours 1compartment NA NA Human Human -DTXSID7044976 Css NA 0.1095 mg/L 3compartmentss NA 50% Human Human -DTXSID7044976 Css NA 0.7794 mg/L 3compartmentss NA 95% Human Human -DTXSID7044976 Css NA 0.08666 mg/L PBTK NA 50% Human Human -DTXSID7044976 Css NA 0.5467 mg/L PBTK NA 95% Human Human -DTXSID7044976 Clint NA 13.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044976 Fup NA 0.299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044976 Vd NA 1.319 L/kg 1compartment NA NA Rat Human +DTXSID7044976 TK.Half.Life NA 2.641 hours 1compartment NA NA Human Human +DTXSID7044976 Css NA 0.05322 mg/L 3compartmentss NA 50% Human Human +DTXSID7044976 Css NA 0.397 mg/L 3compartmentss NA 95% Human Human +DTXSID7044976 Css NA 0.04624 mg/L PBTK NA 50% Human Human +DTXSID7044976 Css NA 0.2981 mg/L PBTK NA 95% Human Human +DTXSID7044976 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044976 Fup 0.451 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7044976 Vd NA 2.024 L/kg 1compartment NA NA Rat Human DTXSID7044976 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7044976 TK.Half.Life NA 1.138 hours 1compartment NA NA Rat Human -DTXSID7044976 Css NA 0.05823 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044976 Css NA 0.3071 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044976 Css NA 0.04446 mg/L PBTK NA 50% Rat Human -DTXSID7044976 Css NA 0.2074 mg/L PBTK NA 95% Rat Human -DTXSID7044978 Clint NA 86.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044978 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7044978 Vd NA 34.84 L/kg 1compartment NA NA Human Human -DTXSID7044978 Days.Css NA 51 Days PBTK NA NA Human Human -DTXSID7044978 TK.Half.Life NA 262.7 hours 1compartment NA NA Human Human -DTXSID7044978 Css NA 0.166 mg/L 3compartmentss NA 50% Human Human -DTXSID7044978 Css NA 0.9949 mg/L 3compartmentss NA 95% Human Human -DTXSID7044978 Css NA 0.6166 mg/L PBTK NA 50% Human Human -DTXSID7044978 Css NA 3.358 mg/L PBTK NA 95% Human Human -DTXSID7044978 Clint NA 86.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044978 Fup NA 0.0087 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7044978 Vd NA 28.95 L/kg 1compartment NA NA Rat Human -DTXSID7044978 Days.Css NA 34 Days PBTK NA NA Rat Human -DTXSID7044978 TK.Half.Life NA 39.38 hours 1compartment NA NA Rat Human -DTXSID7044978 Css NA 0.08556 mg/L 3compartmentss NA 50% Rat Human -DTXSID7044978 Css NA 0.3701 mg/L 3compartmentss NA 95% Rat Human -DTXSID7044978 Css NA 0.3332 mg/L PBTK NA 50% Rat Human -DTXSID7044978 Css NA 1.509 mg/L PBTK NA 95% Rat Human +DTXSID7044976 TK.Half.Life NA 1.035 hours 1compartment NA NA Rat Human +DTXSID7044976 Css NA 0.006402 mg/L 3compartmentss NA 50% Rat Human +DTXSID7044976 Css NA 0.04091 mg/L 3compartmentss NA 95% Rat Human +DTXSID7044976 Css NA 0.00569 mg/L PBTK NA 50% Rat Human +DTXSID7044976 Css NA 0.03113 mg/L PBTK NA 95% Rat Human +DTXSID7045021 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045021 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045021 Vd NA 3.582 L/kg 1compartment NA NA Human Human +DTXSID7045021 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7045021 TK.Half.Life NA 5.231 hours 1compartment NA NA Human Human +DTXSID7045021 Css NA 0.08424 mg/L 3compartmentss NA 50% Human Human +DTXSID7045021 Css NA 0.8357 mg/L 3compartmentss NA 95% Human Human +DTXSID7045021 Css NA 0.09886 mg/L PBTK NA 50% Human Human +DTXSID7045021 Css NA 0.6918 mg/L PBTK NA 95% Human Human +DTXSID7045021 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045021 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045021 Vd NA 4.782 L/kg 1compartment NA NA Rat Human +DTXSID7045021 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7045021 TK.Half.Life NA 2.241 hours 1compartment NA NA Rat Human +DTXSID7045021 Css NA 0.004658 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045021 Css NA 0.0456 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045021 Css NA 0.007416 mg/L PBTK NA 50% Rat Human +DTXSID7045021 Css NA 0.04318 mg/L PBTK NA 95% Rat Human DTXSID7045029 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID7045029 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7045029 Vd NA 2.782 L/kg 1compartment NA NA Human Human -DTXSID7045029 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID7045029 TK.Half.Life NA 41.56 hours 1compartment NA NA Human Human -DTXSID7045029 Css NA 1.452 mg/L 3compartmentss NA 50% Human Human -DTXSID7045029 Css NA 10.98 mg/L 3compartmentss NA 95% Human Human -DTXSID7045029 Css NA 1.46 mg/L PBTK NA 50% Human Human -DTXSID7045029 Css NA 7.895 mg/L PBTK NA 95% Human Human +DTXSID7045029 Vd NA 4.077 L/kg 1compartment NA NA Human Human +DTXSID7045029 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7045029 TK.Half.Life NA 29.62 hours 1compartment NA NA Human Human +DTXSID7045029 Css NA 0.5727 mg/L 3compartmentss NA 50% Human Human +DTXSID7045029 Css NA 4.674 mg/L 3compartmentss NA 95% Human Human +DTXSID7045029 Css NA 0.6817 mg/L PBTK NA 50% Human Human +DTXSID7045029 Css NA 4.047 mg/L PBTK NA 95% Human Human DTXSID7045029 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID7045029 Fup 0.11 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7045029 Vd NA 2.747 L/kg 1compartment NA NA Rat Human -DTXSID7045029 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID7045029 TK.Half.Life NA 22.1 hours 1compartment NA NA Rat Human -DTXSID7045029 Css NA 0.6484 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045029 Css NA 3.863 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045029 Css NA 0.6325 mg/L PBTK NA 50% Rat Human -DTXSID7045029 Css NA 2.577 mg/L PBTK NA 95% Rat Human +DTXSID7045029 Vd NA 3.936 L/kg 1compartment NA NA Rat Human +DTXSID7045029 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7045029 TK.Half.Life NA 15 hours 1compartment NA NA Rat Human +DTXSID7045029 Css NA 0.0659 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045029 Css NA 0.4343 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045029 Css NA 0.08096 mg/L PBTK NA 50% Rat Human +DTXSID7045029 Css NA 0.3522 mg/L PBTK NA 95% Rat Human DTXSID7045079 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7045079 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045079 Vd NA 0.5453 L/kg 1compartment NA NA Human Human +DTXSID7045079 Vd NA 0.6406 L/kg 1compartment NA NA Human Human DTXSID7045079 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045079 TK.Half.Life NA 5.001 hours 1compartment NA NA Human Human -DTXSID7045079 Css NA 1.121 mg/L 3compartmentss NA 50% Human Human -DTXSID7045079 Css NA 7.122 mg/L 3compartmentss NA 95% Human Human -DTXSID7045079 Css NA 0.8713 mg/L PBTK NA 50% Human Human -DTXSID7045079 Css NA 4.478 mg/L PBTK NA 95% Human Human +DTXSID7045079 TK.Half.Life NA 5.874 hours 1compartment NA NA Human Human +DTXSID7045079 Css NA 0.9388 mg/L 3compartmentss NA 50% Human Human +DTXSID7045079 Css NA 6.111 mg/L 3compartmentss NA 95% Human Human +DTXSID7045079 Css NA 0.7519 mg/L PBTK NA 50% Human Human +DTXSID7045079 Css NA 3.908 mg/L PBTK NA 95% Human Human DTXSID7045079 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7045079 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045079 Vd NA 0.5854 L/kg 1compartment NA NA Rat Human +DTXSID7045079 Vd NA 0.6674 L/kg 1compartment NA NA Rat Human DTXSID7045079 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045079 TK.Half.Life NA 1.83 hours 1compartment NA NA Rat Human -DTXSID7045079 Css NA 0.2987 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045079 Css NA 1.854 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045079 Css NA 0.2218 mg/L PBTK NA 50% Rat Human -DTXSID7045079 Css NA 1.078 mg/L PBTK NA 95% Rat Human -DTXSID7045106 Clint NA 0.4073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045106 Fup NA 0.1264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045106 Vd NA 0.3001 L/kg 1compartment NA NA Human Human +DTXSID7045079 TK.Half.Life NA 2.087 hours 1compartment NA NA Rat Human +DTXSID7045079 Css NA 0.01794 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045079 Css NA 0.1437 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045079 Css NA 0.01393 mg/L PBTK NA 50% Rat Human +DTXSID7045079 Css NA 0.09074 mg/L PBTK NA 95% Rat Human +DTXSID7045106 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045106 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045106 Vd NA 0.3751 L/kg 1compartment NA NA Human Human DTXSID7045106 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045106 TK.Half.Life NA 9.221 hours 1compartment NA NA Human Human -DTXSID7045106 Css NA 4.542 mg/L 3compartmentss NA 50% Human Human -DTXSID7045106 Css NA 21.97 mg/L 3compartmentss NA 95% Human Human -DTXSID7045106 Css NA 2.833 mg/L PBTK NA 50% Human Human -DTXSID7045106 Css NA 13.06 mg/L PBTK NA 95% Human Human -DTXSID7045106 Clint NA 0.4073 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045106 Fup NA 0.1264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045106 Vd NA 0.2918 L/kg 1compartment NA NA Rat Human +DTXSID7045106 TK.Half.Life NA 0.9604 hours 1compartment NA NA Human Human +DTXSID7045106 Css NA 0.204 mg/L 3compartmentss NA 50% Human Human +DTXSID7045106 Css NA 1.274 mg/L 3compartmentss NA 95% Human Human +DTXSID7045106 Css NA 0.1368 mg/L PBTK NA 50% Human Human +DTXSID7045106 Css NA 0.8191 mg/L PBTK NA 95% Human Human +DTXSID7045106 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045106 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045106 Vd NA 0.3742 L/kg 1compartment NA NA Rat Human DTXSID7045106 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045106 TK.Half.Life NA 3.842 hours 1compartment NA NA Rat Human -DTXSID7045106 Css NA 1.66 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045106 Css NA 6.702 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045106 Css NA 0.9704 mg/L PBTK NA 50% Rat Human -DTXSID7045106 Css NA 3.7 mg/L PBTK NA 95% Rat Human +DTXSID7045106 TK.Half.Life NA 0.5449 hours 1compartment NA NA Rat Human +DTXSID7045106 Css NA 0.00902 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045106 Css NA 0.06306 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045106 Css NA 0.006008 mg/L PBTK NA 50% Rat Human +DTXSID7045106 Css NA 0.03901 mg/L PBTK NA 95% Rat Human DTXSID7045150 Clint NA 12.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7045150 Fup NA 0.0845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045150 Vd NA 2.938 L/kg 1compartment NA NA Human Human +DTXSID7045150 Vd NA 2.929 L/kg 1compartment NA NA Human Human DTXSID7045150 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID7045150 TK.Half.Life NA 44.18 hours 1compartment NA NA Human Human -DTXSID7045150 Css NA 1.874 mg/L 3compartmentss NA 50% Human Human -DTXSID7045150 Css NA 11.66 mg/L 3compartmentss NA 95% Human Human -DTXSID7045150 Css NA 1.296 mg/L PBTK NA 50% Human Human -DTXSID7045150 Css NA 7.846 mg/L PBTK NA 95% Human Human +DTXSID7045150 TK.Half.Life NA 43.08 hours 1compartment NA NA Human Human +DTXSID7045150 Css NA 1.758 mg/L 3compartmentss NA 50% Human Human +DTXSID7045150 Css NA 10.96 mg/L 3compartmentss NA 95% Human Human +DTXSID7045150 Css NA 1.222 mg/L PBTK NA 50% Human Human +DTXSID7045150 Css NA 7.422 mg/L PBTK NA 95% Human Human DTXSID7045150 Clint NA 12.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7045150 Fup NA 0.0845 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045150 Vd NA 2.206 L/kg 1compartment NA NA Rat Human +DTXSID7045150 Vd NA 2.199 L/kg 1compartment NA NA Rat Human DTXSID7045150 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID7045150 TK.Half.Life NA 7.646 hours 1compartment NA NA Rat Human -DTXSID7045150 Css NA 1.021 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045150 Css NA 4.849 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045150 Css NA 0.6777 mg/L PBTK NA 50% Rat Human -DTXSID7045150 Css NA 3.135 mg/L PBTK NA 95% Rat Human -DTXSID7045152 Clint NA 47.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045152 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045152 Vd NA 3.109 L/kg 1compartment NA NA Human Human -DTXSID7045152 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID7045152 TK.Half.Life NA 40.94 hours 1compartment NA NA Human Human -DTXSID7045152 Css NA 1.541 mg/L 3compartmentss NA 50% Human Human -DTXSID7045152 Css NA 10.08 mg/L 3compartmentss NA 95% Human Human -DTXSID7045152 Css NA 1.069 mg/L PBTK NA 50% Human Human -DTXSID7045152 Css NA 6.752 mg/L PBTK NA 95% Human Human -DTXSID7045152 Clint NA 47.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045152 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045152 Vd NA 2.33 L/kg 1compartment NA NA Rat Human -DTXSID7045152 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID7045152 TK.Half.Life NA 5.899 hours 1compartment NA NA Rat Human -DTXSID7045152 Css NA 0.8719 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045152 Css NA 4.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045152 Css NA 0.578 mg/L PBTK NA 50% Rat Human -DTXSID7045152 Css NA 2.783 mg/L PBTK NA 95% Rat Human -DTXSID7045158 Clint NA 4.225 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045158 Fup NA 0.5291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045158 Vd NA 2.478 L/kg 1compartment NA NA Human Human -DTXSID7045158 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045158 TK.Half.Life NA 4.539 hours 1compartment NA NA Human Human -DTXSID7045158 Css NA 0.1241 mg/L 3compartmentss NA 50% Human Human -DTXSID7045158 Css NA 1.125 mg/L 3compartmentss NA 95% Human Human -DTXSID7045158 Css NA 0.1368 mg/L PBTK NA 50% Human Human -DTXSID7045158 Css NA 0.8749 mg/L PBTK NA 95% Human Human -DTXSID7045158 Clint NA 4.225 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045158 Fup NA 0.5291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045158 Vd NA 2.469 L/kg 1compartment NA NA Rat Human +DTXSID7045150 TK.Half.Life NA 7.527 hours 1compartment NA NA Rat Human +DTXSID7045150 Css NA 0.2236 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045150 Css NA 1.173 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045150 Css NA 0.1538 mg/L PBTK NA 50% Rat Human +DTXSID7045150 Css NA 0.7896 mg/L PBTK NA 95% Rat Human +DTXSID7045152 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045152 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045152 Vd NA 3.012 L/kg 1compartment NA NA Human Human +DTXSID7045152 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID7045152 TK.Half.Life NA 69.73 hours 1compartment NA NA Human Human +DTXSID7045152 Css NA 2.883 mg/L 3compartmentss NA 50% Human Human +DTXSID7045152 Css NA 19.39 mg/L 3compartmentss NA 95% Human Human +DTXSID7045152 Css NA 1.977 mg/L PBTK NA 50% Human Human +DTXSID7045152 Css NA 12.73 mg/L PBTK NA 95% Human Human +DTXSID7045152 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045152 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045152 Vd NA 2.254 L/kg 1compartment NA NA Rat Human +DTXSID7045152 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID7045152 TK.Half.Life NA 10.84 hours 1compartment NA NA Rat Human +DTXSID7045152 Css NA 0.3698 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045152 Css NA 2.225 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045152 Css NA 0.252 mg/L PBTK NA 50% Rat Human +DTXSID7045152 Css NA 1.46 mg/L PBTK NA 95% Rat Human +DTXSID7045158 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045158 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045158 Vd NA 1.004 L/kg 1compartment NA NA Human Human +DTXSID7045158 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7045158 TK.Half.Life NA 17.29 hours 1compartment NA NA Human Human +DTXSID7045158 Css NA 1.773 mg/L 3compartmentss NA 50% Human Human +DTXSID7045158 Css NA 7.746 mg/L 3compartmentss NA 95% Human Human +DTXSID7045158 Css NA 1.384 mg/L PBTK NA 50% Human Human +DTXSID7045158 Css NA 5.124 mg/L PBTK NA 95% Human Human +DTXSID7045158 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045158 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045158 Vd NA 0.8905 L/kg 1compartment NA NA Rat Human DTXSID7045158 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045158 TK.Half.Life NA 2.568 hours 1compartment NA NA Rat Human -DTXSID7045158 Css NA 0.05749 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045158 Css NA 0.4426 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045158 Css NA 0.0638 mg/L PBTK NA 50% Rat Human -DTXSID7045158 Css NA 0.3153 mg/L PBTK NA 95% Rat Human -DTXSID7045281 Clint NA 5.404 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045281 Fup NA 0.1076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045281 Vd NA 0.27 L/kg 1compartment NA NA Human Human -DTXSID7045281 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045281 TK.Half.Life NA 1.81 hours 1compartment NA NA Human Human -DTXSID7045281 Css NA 1.005 mg/L 3compartmentss NA 50% Human Human -DTXSID7045281 Css NA 6.544 mg/L 3compartmentss NA 95% Human Human -DTXSID7045281 Css NA 0.6225 mg/L PBTK NA 50% Human Human -DTXSID7045281 Css NA 3.944 mg/L PBTK NA 95% Human Human -DTXSID7045281 Clint NA 5.404 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045281 Fup NA 0.1076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045281 Vd NA 0.2699 L/kg 1compartment NA NA Rat Human +DTXSID7045158 TK.Half.Life NA 4.965 hours 1compartment NA NA Rat Human +DTXSID7045158 Css NA 0.111 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045158 Css NA 0.4119 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045158 Css NA 0.08654 mg/L PBTK NA 50% Rat Human +DTXSID7045158 Css NA 0.2607 mg/L PBTK NA 95% Rat Human +DTXSID7045281 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045281 Fup 0.205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045281 Vd NA 0.3223 L/kg 1compartment NA NA Human Human +DTXSID7045281 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7045281 TK.Half.Life NA 10.17 hours 1compartment NA NA Human Human +DTXSID7045281 Css NA 2.106 mg/L 3compartmentss NA 50% Human Human +DTXSID7045281 Css NA 8.394 mg/L 3compartmentss NA 95% Human Human +DTXSID7045281 Css NA 1.381 mg/L PBTK NA 50% Human Human +DTXSID7045281 Css NA 5.109 mg/L PBTK NA 95% Human Human +DTXSID7045281 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045281 Fup 0.205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045281 Vd NA 0.3264 L/kg 1compartment NA NA Rat Human DTXSID7045281 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045281 TK.Half.Life NA 1.095 hours 1compartment NA NA Rat Human -DTXSID7045281 Css NA 0.523 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045281 Css NA 2.536 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045281 Css NA 0.3024 mg/L PBTK NA 50% Rat Human -DTXSID7045281 Css NA 1.404 mg/L PBTK NA 95% Rat Human -DTXSID7045287 Clint NA 9.138 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045287 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045287 Vd NA 0.2166 L/kg 1compartment NA NA Human Human +DTXSID7045281 TK.Half.Life NA 3.51 hours 1compartment NA NA Rat Human +DTXSID7045281 Css NA 0.01131 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045281 Css NA 0.04559 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045281 Css NA 0.007012 mg/L PBTK NA 50% Rat Human +DTXSID7045281 Css NA 0.02636 mg/L PBTK NA 95% Rat Human +DTXSID7045287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045287 Fup 0.0941 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045287 Vd NA 0.2549 L/kg 1compartment NA NA Human Human DTXSID7045287 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045287 TK.Half.Life NA 1.648 hours 1compartment NA NA Human Human -DTXSID7045287 Css NA 1.234 mg/L 3compartmentss NA 50% Human Human -DTXSID7045287 Css NA 8.642 mg/L 3compartmentss NA 95% Human Human -DTXSID7045287 Css NA 0.74 mg/L PBTK NA 50% Human Human -DTXSID7045287 Css NA 5.114 mg/L PBTK NA 95% Human Human -DTXSID7045287 Clint NA 9.138 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045287 Fup NA 0.0592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045287 Vd NA 0.2147 L/kg 1compartment NA NA Rat Human +DTXSID7045287 TK.Half.Life NA 0.6973 hours 1compartment NA NA Human Human +DTXSID7045287 Css NA 0.3134 mg/L 3compartmentss NA 50% Human Human +DTXSID7045287 Css NA 2.531 mg/L 3compartmentss NA 95% Human Human +DTXSID7045287 Css NA 0.1901 mg/L PBTK NA 50% Human Human +DTXSID7045287 Css NA 1.512 mg/L PBTK NA 95% Human Human +DTXSID7045287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045287 Fup 0.0941 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045287 Vd NA 0.2521 L/kg 1compartment NA NA Rat Human DTXSID7045287 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045287 TK.Half.Life NA 1.028 hours 1compartment NA NA Rat Human -DTXSID7045287 Css NA 0.6773 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045287 Css NA 3.545 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045287 Css NA 0.3781 mg/L PBTK NA 50% Rat Human -DTXSID7045287 Css NA 1.934 mg/L PBTK NA 95% Rat Human -DTXSID7045310 Clint NA 97.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045310 Fup NA 0.035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045310 Vd NA 1.962 L/kg 1compartment NA NA Human Human -DTXSID7045310 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045310 TK.Half.Life NA 4.368 hours 1compartment NA NA Human Human -DTXSID7045310 Css NA 0.2244 mg/L 3compartmentss NA 50% Human Human -DTXSID7045310 Css NA 1.705 mg/L 3compartmentss NA 95% Human Human -DTXSID7045310 Css NA 0.1451 mg/L PBTK NA 50% Human Human -DTXSID7045310 Css NA 1.064 mg/L PBTK NA 95% Human Human -DTXSID7045310 Clint NA 97.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045310 Fup NA 0.035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045310 Vd NA 1.466 L/kg 1compartment NA NA Rat Human -DTXSID7045310 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045310 TK.Half.Life NA 1.449 hours 1compartment NA NA Rat Human -DTXSID7045310 Css NA 0.1281 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045310 Css NA 0.7853 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045310 Css NA 0.07837 mg/L PBTK NA 50% Rat Human -DTXSID7045310 Css NA 0.4636 mg/L PBTK NA 95% Rat Human -DTXSID7045312 Clint NA 3.754 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045312 Fup NA 0.3341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045312 Vd NA 0.9554 L/kg 1compartment NA NA Human Human +DTXSID7045287 TK.Half.Life NA 0.4114 hours 1compartment NA NA Rat Human +DTXSID7045287 Css NA 0.04101 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045287 Css NA 0.263 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045287 Css NA 0.02429 mg/L PBTK NA 50% Rat Human +DTXSID7045287 Css NA 0.1521 mg/L PBTK NA 95% Rat Human +DTXSID7045310 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045310 Fup 0.0297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045310 Vd NA 3.025 L/kg 1compartment NA NA Human Human +DTXSID7045310 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID7045310 TK.Half.Life NA 56.54 hours 1compartment NA NA Human Human +DTXSID7045310 Css NA 2.26 mg/L 3compartmentss NA 50% Human Human +DTXSID7045310 Css NA 15.77 mg/L 3compartmentss NA 95% Human Human +DTXSID7045310 Css NA 1.559 mg/L PBTK NA 50% Human Human +DTXSID7045310 Css NA 10.5 mg/L PBTK NA 95% Human Human +DTXSID7045310 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045310 Fup 0.0297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045310 Vd NA 2.266 L/kg 1compartment NA NA Rat Human +DTXSID7045310 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID7045310 TK.Half.Life NA 8.79 hours 1compartment NA NA Rat Human +DTXSID7045310 Css NA 0.2954 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045310 Css NA 1.714 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045310 Css NA 0.2021 mg/L PBTK NA 50% Rat Human +DTXSID7045310 Css NA 1.148 mg/L PBTK NA 95% Rat Human +DTXSID7045312 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045312 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045312 Vd NA 0.786 L/kg 1compartment NA NA Human Human DTXSID7045312 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045312 TK.Half.Life NA 3.182 hours 1compartment NA NA Human Human -DTXSID7045312 Css NA 0.3214 mg/L 3compartmentss NA 50% Human Human -DTXSID7045312 Css NA 1.87 mg/L 3compartmentss NA 95% Human Human -DTXSID7045312 Css NA 0.242 mg/L PBTK NA 50% Human Human -DTXSID7045312 Css NA 1.277 mg/L PBTK NA 95% Human Human -DTXSID7045312 Clint NA 3.754 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045312 Fup NA 0.3341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045312 Vd NA 0.8372 L/kg 1compartment NA NA Rat Human +DTXSID7045312 TK.Half.Life NA 1.119 hours 1compartment NA NA Human Human +DTXSID7045312 Css NA 0.08125 mg/L 3compartmentss NA 50% Human Human +DTXSID7045312 Css NA 0.5936 mg/L 3compartmentss NA 95% Human Human +DTXSID7045312 Css NA 0.05752 mg/L PBTK NA 50% Human Human +DTXSID7045312 Css NA 0.392 mg/L PBTK NA 95% Human Human +DTXSID7045312 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045312 Fup 0.257 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045312 Vd NA 0.6937 L/kg 1compartment NA NA Rat Human DTXSID7045312 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045312 TK.Half.Life NA 1.514 hours 1compartment NA NA Rat Human -DTXSID7045312 Css NA 0.1557 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045312 Css NA 0.6714 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045312 Css NA 0.1128 mg/L PBTK NA 50% Rat Human -DTXSID7045312 Css NA 0.4167 mg/L PBTK NA 95% Rat Human -DTXSID7045316 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045316 Fup NA 0.4722 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045316 Vd NA 1.35 L/kg 1compartment NA NA Human Human +DTXSID7045312 TK.Half.Life NA 0.5259 hours 1compartment NA NA Rat Human +DTXSID7045312 Css NA 0.01014 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045312 Css NA 0.05756 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045312 Css NA 0.007182 mg/L PBTK NA 50% Rat Human +DTXSID7045312 Css NA 0.03738 mg/L PBTK NA 95% Rat Human +DTXSID7045316 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045316 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045316 Vd NA 1.116 L/kg 1compartment NA NA Human Human DTXSID7045316 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045316 TK.Half.Life NA 1.481 hours 1compartment NA NA Human Human -DTXSID7045316 Css NA 0.05608 mg/L 3compartmentss NA 50% Human Human -DTXSID7045316 Css NA 0.4927 mg/L 3compartmentss NA 95% Human Human -DTXSID7045316 Css NA 0.04936 mg/L PBTK NA 50% Human Human -DTXSID7045316 Css NA 0.3607 mg/L PBTK NA 95% Human Human -DTXSID7045316 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045316 Fup NA 0.4722 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045316 Vd NA 1.332 L/kg 1compartment NA NA Rat Human +DTXSID7045316 TK.Half.Life NA 2.099 hours 1compartment NA NA Human Human +DTXSID7045316 Css NA 0.1366 mg/L 3compartmentss NA 50% Human Human +DTXSID7045316 Css NA 0.9693 mg/L 3compartmentss NA 95% Human Human +DTXSID7045316 Css NA 0.1135 mg/L PBTK NA 50% Human Human +DTXSID7045316 Css NA 0.6914 mg/L PBTK NA 95% Human Human +DTXSID7045316 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045316 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045316 Vd NA 1.101 L/kg 1compartment NA NA Rat Human DTXSID7045316 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045316 TK.Half.Life NA 0.7831 hours 1compartment NA NA Rat Human -DTXSID7045316 Css NA 0.02902 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045316 Css NA 0.1965 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045316 Css NA 0.0249 mg/L PBTK NA 50% Rat Human -DTXSID7045316 Css NA 0.1362 mg/L PBTK NA 95% Rat Human -DTXSID7045318 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045318 Fup NA 0.4262 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045318 Vd NA 0.3674 L/kg 1compartment NA NA Human Human +DTXSID7045316 TK.Half.Life NA 1.166 hours 1compartment NA NA Rat Human +DTXSID7045316 Css NA 0.0157 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045316 Css NA 0.0885 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045316 Css NA 0.01312 mg/L PBTK NA 50% Rat Human +DTXSID7045316 Css NA 0.05997 mg/L PBTK NA 95% Rat Human +DTXSID7045318 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045318 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045318 Vd NA 0.392 L/kg 1compartment NA NA Human Human DTXSID7045318 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045318 TK.Half.Life NA 5.576 hours 1compartment NA NA Human Human -DTXSID7045318 Css NA 1.847 mg/L 3compartmentss NA 50% Human Human -DTXSID7045318 Css NA 8.094 mg/L 3compartmentss NA 95% Human Human -DTXSID7045318 Css NA 1.264 mg/L PBTK NA 50% Human Human -DTXSID7045318 Css NA 4.938 mg/L PBTK NA 95% Human Human -DTXSID7045318 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045318 Fup NA 0.4262 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045318 Vd NA 0.383 L/kg 1compartment NA NA Rat Human +DTXSID7045318 TK.Half.Life NA 5.899 hours 1compartment NA NA Human Human +DTXSID7045318 Css NA 0.9695 mg/L 3compartmentss NA 50% Human Human +DTXSID7045318 Css NA 4.526 mg/L 3compartmentss NA 95% Human Human +DTXSID7045318 Css NA 0.6754 mg/L PBTK NA 50% Human Human +DTXSID7045318 Css NA 2.824 mg/L PBTK NA 95% Human Human +DTXSID7045318 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045318 Fup 0.43 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045318 Vd NA 0.4041 L/kg 1compartment NA NA Rat Human DTXSID7045318 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045318 TK.Half.Life NA 1.981 hours 1compartment NA NA Rat Human -DTXSID7045318 Css NA 0.5054 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045318 Css NA 1.843 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045318 Css NA 0.3288 mg/L PBTK NA 50% Rat Human -DTXSID7045318 Css NA 1.059 mg/L PBTK NA 95% Rat Human -DTXSID7045360 Clint NA 5.565 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045360 Fup NA 0.1062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045360 Vd NA 3.163 L/kg 1compartment NA NA Human Human -DTXSID7045360 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID7045360 TK.Half.Life NA 41.88 hours 1compartment NA NA Human Human -DTXSID7045360 Css NA 1.569 mg/L 3compartmentss NA 50% Human Human -DTXSID7045360 Css NA 8.9 mg/L 3compartmentss NA 95% Human Human -DTXSID7045360 Css NA 1.169 mg/L PBTK NA 50% Human Human -DTXSID7045360 Css NA 6.383 mg/L PBTK NA 95% Human Human -DTXSID7045360 Clint NA 5.565 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045360 Fup NA 0.1062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045360 Vd NA 2.52 L/kg 1compartment NA NA Rat Human -DTXSID7045360 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID7045360 TK.Half.Life NA 8.981 hours 1compartment NA NA Rat Human -DTXSID7045360 Css NA 0.8244 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045360 Css NA 3.659 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045360 Css NA 0.5976 mg/L PBTK NA 50% Rat Human -DTXSID7045360 Css NA 2.509 mg/L PBTK NA 95% Rat Human -DTXSID7045364 Clint NA 48.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045364 Fup NA 0.112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045364 Vd NA 2.88 L/kg 1compartment NA NA Human Human -DTXSID7045364 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045364 TK.Half.Life NA 9.565 hours 1compartment NA NA Human Human -DTXSID7045364 Css NA 0.3308 mg/L 3compartmentss NA 50% Human Human -DTXSID7045364 Css NA 2.047 mg/L 3compartmentss NA 95% Human Human -DTXSID7045364 Css NA 0.231 mg/L PBTK NA 50% Human Human -DTXSID7045364 Css NA 1.394 mg/L PBTK NA 95% Human Human -DTXSID7045364 Clint NA 48.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045364 Fup NA 0.112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045364 Vd NA 2.173 L/kg 1compartment NA NA Rat Human -DTXSID7045364 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045364 TK.Half.Life NA 2.09 hours 1compartment NA NA Rat Human -DTXSID7045364 Css NA 0.1847 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045364 Css NA 0.9771 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045364 Css NA 0.1238 mg/L PBTK NA 50% Rat Human -DTXSID7045364 Css NA 0.6247 mg/L PBTK NA 95% Rat Human -DTXSID7045366 Clint NA 4.425 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045366 Fup NA 0.1725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045366 Vd NA 0.4648 L/kg 1compartment NA NA Human Human +DTXSID7045318 TK.Half.Life NA 2.072 hours 1compartment NA NA Rat Human +DTXSID7045318 Css NA 0.005232 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045318 Css NA 0.02466 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045318 Css NA 0.003445 mg/L PBTK NA 50% Rat Human +DTXSID7045318 Css NA 0.01465 mg/L PBTK NA 95% Rat Human +DTXSID7045360 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045360 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045360 Vd NA 2.97 L/kg 1compartment NA NA Human Human +DTXSID7045360 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7045360 TK.Half.Life NA 4.082 hours 1compartment NA NA Human Human +DTXSID7045360 Css NA 0.07464 mg/L 3compartmentss NA 50% Human Human +DTXSID7045360 Css NA 0.5486 mg/L 3compartmentss NA 95% Human Human +DTXSID7045360 Css NA 0.06954 mg/L PBTK NA 50% Human Human +DTXSID7045360 Css NA 0.4436 mg/L PBTK NA 95% Human Human +DTXSID7045360 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045360 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045360 Vd NA 2.736 L/kg 1compartment NA NA Rat Human +DTXSID7045360 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7045360 TK.Half.Life NA 1.83 hours 1compartment NA NA Rat Human +DTXSID7045360 Css NA 0.009221 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045360 Css NA 0.05263 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045360 Css NA 0.00876 mg/L PBTK NA 50% Rat Human +DTXSID7045360 Css NA 0.04352 mg/L PBTK NA 95% Rat Human +DTXSID7045364 Clint 10 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID7045364 Fup 0.219 NA NA Williamson 2020 NA Human Human +DTXSID7045364 Vd NA 3.028 L/kg 1compartment NA NA Human Human +DTXSID7045364 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID7045364 TK.Half.Life NA 35.86 hours 1compartment NA NA Human Human +DTXSID7045364 Css NA 1.305 mg/L 3compartmentss NA 50% Human Human +DTXSID7045364 Css NA 7.635 mg/L 3compartmentss NA 95% Human Human +DTXSID7045364 Css NA 0.93 mg/L PBTK NA 50% Human Human +DTXSID7045364 Css NA 5.178 mg/L PBTK NA 95% Human Human +DTXSID7045364 Clint 10 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID7045364 Fup 0.219 NA NA Williamson 2020 NA Rat Human +DTXSID7045364 Vd NA 2.29 L/kg 1compartment NA NA Rat Human +DTXSID7045364 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7045364 TK.Half.Life NA 5.894 hours 1compartment NA NA Rat Human +DTXSID7045364 Css NA 0.1622 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045364 Css NA 0.731 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045364 Css NA 0.1157 mg/L PBTK NA 50% Rat Human +DTXSID7045364 Css NA 0.4897 mg/L PBTK NA 95% Rat Human +DTXSID7045366 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045366 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045366 Vd NA 0.4244 L/kg 1compartment NA NA Human Human DTXSID7045366 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045366 TK.Half.Life NA 2.39 hours 1compartment NA NA Human Human -DTXSID7045366 Css NA 0.5824 mg/L 3compartmentss NA 50% Human Human -DTXSID7045366 Css NA 3.171 mg/L 3compartmentss NA 95% Human Human -DTXSID7045366 Css NA 0.388 mg/L PBTK NA 50% Human Human -DTXSID7045366 Css NA 1.963 mg/L PBTK NA 95% Human Human -DTXSID7045366 Clint NA 4.425 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045366 Fup NA 0.1725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045366 Vd NA 0.4262 L/kg 1compartment NA NA Rat Human +DTXSID7045366 TK.Half.Life NA 2.088 hours 1compartment NA NA Human Human +DTXSID7045366 Css NA 0.6406 mg/L 3compartmentss NA 50% Human Human +DTXSID7045366 Css NA 4.434 mg/L 3compartmentss NA 95% Human Human +DTXSID7045366 Css NA 0.4109 mg/L PBTK NA 50% Human Human +DTXSID7045366 Css NA 2.67 mg/L PBTK NA 95% Human Human +DTXSID7045366 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045366 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045366 Vd NA 0.3872 L/kg 1compartment NA NA Rat Human DTXSID7045366 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045366 TK.Half.Life NA 1.279 hours 1compartment NA NA Rat Human -DTXSID7045366 Css NA 0.2882 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045366 Css NA 1.167 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045366 Css NA 0.1824 mg/L PBTK NA 50% Rat Human -DTXSID7045366 Css NA 0.6832 mg/L PBTK NA 95% Rat Human -DTXSID7045368 Clint NA 3.187 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045368 Fup NA 0.2182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045368 Vd NA 1.14 L/kg 1compartment NA NA Human Human +DTXSID7045366 TK.Half.Life NA 1.139 hours 1compartment NA NA Rat Human +DTXSID7045366 Css NA 0.07847 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045366 Css NA 0.4016 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045366 Css NA 0.0489 mg/L PBTK NA 50% Rat Human +DTXSID7045366 Css NA 0.2343 mg/L PBTK NA 95% Rat Human +DTXSID7045368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045368 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045368 Vd NA 1.379 L/kg 1compartment NA NA Human Human DTXSID7045368 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045368 TK.Half.Life NA 6.515 hours 1compartment NA NA Human Human -DTXSID7045368 Css NA 0.6262 mg/L 3compartmentss NA 50% Human Human -DTXSID7045368 Css NA 3.183 mg/L 3compartmentss NA 95% Human Human -DTXSID7045368 Css NA 0.4462 mg/L PBTK NA 50% Human Human -DTXSID7045368 Css NA 2.099 mg/L PBTK NA 95% Human Human -DTXSID7045368 Clint NA 3.187 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045368 Fup NA 0.2182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045368 Vd NA 0.9265 L/kg 1compartment NA NA Rat Human +DTXSID7045368 TK.Half.Life NA 3.715 hours 1compartment NA NA Human Human +DTXSID7045368 Css NA 0.2335 mg/L 3compartmentss NA 50% Human Human +DTXSID7045368 Css NA 1.457 mg/L 3compartmentss NA 95% Human Human +DTXSID7045368 Css NA 0.1757 mg/L PBTK NA 50% Human Human +DTXSID7045368 Css NA 1.003 mg/L PBTK NA 95% Human Human +DTXSID7045368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045368 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045368 Vd NA 1.125 L/kg 1compartment NA NA Rat Human DTXSID7045368 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045368 TK.Half.Life NA 2.76 hours 1compartment NA NA Rat Human -DTXSID7045368 Css NA 0.3023 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045368 Css NA 1.141 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045368 Css NA 0.2052 mg/L PBTK NA 50% Rat Human -DTXSID7045368 Css NA 0.695 mg/L PBTK NA 95% Rat Human -DTXSID7045441 Clint NA 9.669 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045441 Fup NA 0.1036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045441 Vd NA 1.256 L/kg 1compartment NA NA Human Human +DTXSID7045368 TK.Half.Life NA 1.55 hours 1compartment NA NA Rat Human +DTXSID7045368 Css NA 0.02746 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045368 Css NA 0.1209 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045368 Css NA 0.02071 mg/L PBTK NA 50% Rat Human +DTXSID7045368 Css NA 0.08124 mg/L PBTK NA 95% Rat Human +DTXSID7045441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045441 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045441 Vd NA 2.961 L/kg 1compartment NA NA Human Human DTXSID7045441 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045441 TK.Half.Life NA 5.259 hours 1compartment NA NA Human Human -DTXSID7045441 Css NA 0.5248 mg/L 3compartmentss NA 50% Human Human -DTXSID7045441 Css NA 4.09 mg/L 3compartmentss NA 95% Human Human -DTXSID7045441 Css NA 0.3668 mg/L PBTK NA 50% Human Human -DTXSID7045441 Css NA 2.624 mg/L PBTK NA 95% Human Human -DTXSID7045441 Clint NA 9.669 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045441 Fup NA 0.1036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045441 Vd NA 1.208 L/kg 1compartment NA NA Rat Human +DTXSID7045441 TK.Half.Life NA 3.669 hours 1compartment NA NA Human Human +DTXSID7045441 Css NA 0.06175 mg/L 3compartmentss NA 50% Human Human +DTXSID7045441 Css NA 0.4689 mg/L 3compartmentss NA 95% Human Human +DTXSID7045441 Css NA 0.05993 mg/L PBTK NA 50% Human Human +DTXSID7045441 Css NA 0.3909 mg/L PBTK NA 95% Human Human +DTXSID7045441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045441 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045441 Vd NA 2.806 L/kg 1compartment NA NA Rat Human DTXSID7045441 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045441 TK.Half.Life NA 3.068 hours 1compartment NA NA Rat Human -DTXSID7045441 Css NA 0.2812 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045441 Css NA 1.663 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045441 Css NA 0.1864 mg/L PBTK NA 50% Rat Human -DTXSID7045441 Css NA 0.9818 mg/L PBTK NA 95% Rat Human -DTXSID7045443 Clint NA 92.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045443 Fup NA 0.1066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045443 Vd NA 1.374 L/kg 1compartment NA NA Human Human +DTXSID7045441 TK.Half.Life NA 1.765 hours 1compartment NA NA Rat Human +DTXSID7045441 Css NA 0.00751 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045441 Css NA 0.04648 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045441 Css NA 0.0075 mg/L PBTK NA 50% Rat Human +DTXSID7045441 Css NA 0.03869 mg/L PBTK NA 95% Rat Human +DTXSID7045443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045443 Fup 0.0948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045443 Vd NA 1.401 L/kg 1compartment NA NA Human Human DTXSID7045443 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045443 TK.Half.Life NA 1.677 hours 1compartment NA NA Human Human -DTXSID7045443 Css NA 0.06432 mg/L 3compartmentss NA 50% Human Human -DTXSID7045443 Css NA 0.5406 mg/L 3compartmentss NA 95% Human Human -DTXSID7045443 Css NA 0.04386 mg/L PBTK NA 50% Human Human -DTXSID7045443 Css NA 0.3485 mg/L PBTK NA 95% Human Human -DTXSID7045443 Clint NA 92.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045443 Fup NA 0.1066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045443 Vd NA 1.142 L/kg 1compartment NA NA Rat Human +DTXSID7045443 TK.Half.Life NA 3.864 hours 1compartment NA NA Human Human +DTXSID7045443 Css NA 0.2928 mg/L 3compartmentss NA 50% Human Human +DTXSID7045443 Css NA 2.436 mg/L 3compartmentss NA 95% Human Human +DTXSID7045443 Css NA 0.1971 mg/L PBTK NA 50% Human Human +DTXSID7045443 Css NA 1.526 mg/L PBTK NA 95% Human Human +DTXSID7045443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045443 Fup 0.0948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045443 Vd NA 1.151 L/kg 1compartment NA NA Rat Human DTXSID7045443 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045443 TK.Half.Life NA 0.687 hours 1compartment NA NA Rat Human -DTXSID7045443 Css NA 0.03623 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045443 Css NA 0.2423 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045443 Css NA 0.02336 mg/L PBTK NA 50% Rat Human -DTXSID7045443 Css NA 0.1483 mg/L PBTK NA 95% Rat Human -DTXSID7045447 Clint NA 19.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045447 Fup NA 0.0169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045447 Vd NA 2.433 L/kg 1compartment NA NA Human Human -DTXSID7045447 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7045447 TK.Half.Life NA 34.76 hours 1compartment NA NA Human Human -DTXSID7045447 Css NA 2.08 mg/L 3compartmentss NA 50% Human Human -DTXSID7045447 Css NA 15.99 mg/L 3compartmentss NA 95% Human Human -DTXSID7045447 Css NA 1.37 mg/L PBTK NA 50% Human Human -DTXSID7045447 Css NA 10.06 mg/L PBTK NA 95% Human Human -DTXSID7045447 Clint NA 19.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045447 Fup NA 0.0169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045447 Vd NA 1.822 L/kg 1compartment NA NA Rat Human -DTXSID7045447 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7045447 TK.Half.Life NA 9.093 hours 1compartment NA NA Rat Human -DTXSID7045447 Css NA 1.163 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045447 Css NA 6.932 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045447 Css NA 0.7288 mg/L PBTK NA 50% Rat Human -DTXSID7045447 Css NA 4.149 mg/L PBTK NA 95% Rat Human -DTXSID7045493 Clint NA 6.736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045493 Fup NA 0.2668 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045493 Vd NA 1.712 L/kg 1compartment NA NA Human Human +DTXSID7045443 TK.Half.Life NA 1.723 hours 1compartment NA NA Rat Human +DTXSID7045443 Css NA 0.03881 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045443 Css NA 0.2353 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045443 Css NA 0.02554 mg/L PBTK NA 50% Rat Human +DTXSID7045443 Css NA 0.1458 mg/L PBTK NA 95% Rat Human +DTXSID7045447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045447 Fup 0.00539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045447 Vd NA 3.042 L/kg 1compartment NA NA Human Human +DTXSID7045447 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID7045447 TK.Half.Life NA 88.48 hours 1compartment NA NA Human Human +DTXSID7045447 Css NA 3.569 mg/L 3compartmentss NA 50% Human Human +DTXSID7045447 Css NA 23.5 mg/L 3compartmentss NA 95% Human Human +DTXSID7045447 Css NA 2.471 mg/L PBTK NA 50% Human Human +DTXSID7045447 Css NA 15.68 mg/L PBTK NA 95% Human Human +DTXSID7045447 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045447 Fup 0.00539 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045447 Vd NA 2.277 L/kg 1compartment NA NA Rat Human +DTXSID7045447 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID7045447 TK.Half.Life NA 13.22 hours 1compartment NA NA Rat Human +DTXSID7045447 Css NA 0.4687 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045447 Css NA 2.5 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045447 Css NA 0.3183 mg/L PBTK NA 50% Rat Human +DTXSID7045447 Css NA 1.696 mg/L PBTK NA 95% Rat Human +DTXSID7045493 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045493 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045493 Vd NA 1.05 L/kg 1compartment NA NA Human Human DTXSID7045493 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045493 TK.Half.Life NA 5.283 hours 1compartment NA NA Human Human -DTXSID7045493 Css NA 0.2841 mg/L 3compartmentss NA 50% Human Human -DTXSID7045493 Css NA 1.736 mg/L 3compartmentss NA 95% Human Human -DTXSID7045493 Css NA 0.2177 mg/L PBTK NA 50% Human Human -DTXSID7045493 Css NA 1.179 mg/L PBTK NA 95% Human Human -DTXSID7045493 Clint NA 6.736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045493 Fup NA 0.2668 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045493 Vd NA 1.398 L/kg 1compartment NA NA Rat Human +DTXSID7045493 TK.Half.Life NA 1.903 hours 1compartment NA NA Human Human +DTXSID7045493 Css NA 0.1323 mg/L 3compartmentss NA 50% Human Human +DTXSID7045493 Css NA 0.9357 mg/L 3compartmentss NA 95% Human Human +DTXSID7045493 Css NA 0.1065 mg/L PBTK NA 50% Human Human +DTXSID7045493 Css NA 0.6531 mg/L PBTK NA 95% Human Human +DTXSID7045493 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045493 Fup 0.462 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045493 Vd NA 0.9844 L/kg 1compartment NA NA Rat Human DTXSID7045493 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045493 TK.Half.Life NA 2.118 hours 1compartment NA NA Rat Human -DTXSID7045493 Css NA 0.1457 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045493 Css NA 0.6143 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045493 Css NA 0.1071 mg/L PBTK NA 50% Rat Human -DTXSID7045493 Css NA 0.4047 mg/L PBTK NA 95% Rat Human -DTXSID7045497 Clint NA 19.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045497 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045497 Vd NA 0.4629 L/kg 1compartment NA NA Human Human -DTXSID7045497 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045497 TK.Half.Life NA 4.948 hours 1compartment NA NA Human Human -DTXSID7045497 Css NA 1.86 mg/L 3compartmentss NA 50% Human Human -DTXSID7045497 Css NA 18.23 mg/L 3compartmentss NA 95% Human Human -DTXSID7045497 Css NA 1.111 mg/L PBTK NA 50% Human Human -DTXSID7045497 Css NA 10.7 mg/L PBTK NA 95% Human Human -DTXSID7045497 Clint NA 19.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045497 Fup NA 0.0188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045497 Vd NA 0.3652 L/kg 1compartment NA NA Rat Human +DTXSID7045493 TK.Half.Life NA 0.9726 hours 1compartment NA NA Rat Human +DTXSID7045493 Css NA 0.01534 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045493 Css NA 0.09056 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045493 Css NA 0.01245 mg/L PBTK NA 50% Rat Human +DTXSID7045493 Css NA 0.05913 mg/L PBTK NA 95% Rat Human +DTXSID7045497 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045497 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045497 Vd NA 2.894 L/kg 1compartment NA NA Human Human +DTXSID7045497 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7045497 TK.Half.Life NA 15.07 hours 1compartment NA NA Human Human +DTXSID7045497 Css NA 0.4178 mg/L 3compartmentss NA 50% Human Human +DTXSID7045497 Css NA 2.478 mg/L 3compartmentss NA 95% Human Human +DTXSID7045497 Css NA 0.3402 mg/L PBTK NA 50% Human Human +DTXSID7045497 Css NA 1.882 mg/L PBTK NA 95% Human Human +DTXSID7045497 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045497 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045497 Vd NA 2.397 L/kg 1compartment NA NA Rat Human DTXSID7045497 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045497 TK.Half.Life NA 2.516 hours 1compartment NA NA Rat Human -DTXSID7045497 Css NA 1.042 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045497 Css NA 8.276 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045497 Css NA 0.5768 mg/L PBTK NA 50% Rat Human -DTXSID7045497 Css NA 4.503 mg/L PBTK NA 95% Rat Human -DTXSID7045522 Clint NA 37.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045522 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045522 Vd NA 0.1937 L/kg 1compartment NA NA Human Human +DTXSID7045497 TK.Half.Life NA 4.563 hours 1compartment NA NA Rat Human +DTXSID7045497 Css NA 0.01917 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045497 Css NA 0.1202 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045497 Css NA 0.01568 mg/L PBTK NA 50% Rat Human +DTXSID7045497 Css NA 0.08799 mg/L PBTK NA 95% Rat Human +DTXSID7045522 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045522 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045522 Vd NA 0.2524 L/kg 1compartment NA NA Human Human DTXSID7045522 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045522 TK.Half.Life NA 3.442 hours 1compartment NA NA Human Human -DTXSID7045522 Css NA 3.31 mg/L 3compartmentss NA 50% Human Human -DTXSID7045522 Css NA 31.5 mg/L 3compartmentss NA 95% Human Human -DTXSID7045522 Css NA 1.95 mg/L PBTK NA 50% Human Human -DTXSID7045522 Css NA 18.3 mg/L PBTK NA 95% Human Human -DTXSID7045522 Clint NA 37.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045522 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045522 Vd NA 0.1882 L/kg 1compartment NA NA Rat Human +DTXSID7045522 TK.Half.Life NA 2.415 hours 1compartment NA NA Human Human +DTXSID7045522 Css NA 1.605 mg/L 3compartmentss NA 50% Human Human +DTXSID7045522 Css NA 15.67 mg/L 3compartmentss NA 95% Human Human +DTXSID7045522 Css NA 0.962 mg/L PBTK NA 50% Human Human +DTXSID7045522 Css NA 9.089 mg/L PBTK NA 95% Human Human +DTXSID7045522 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045522 Fup 0.0201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045522 Vd NA 0.2439 L/kg 1compartment NA NA Rat Human DTXSID7045522 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045522 TK.Half.Life NA 2.262 hours 1compartment NA NA Rat Human -DTXSID7045522 Css NA 1.88 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045522 Css NA 15.86 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045522 Css NA 1.027 mg/L PBTK NA 50% Rat Human -DTXSID7045522 Css NA 8.576 mg/L PBTK NA 95% Rat Human -DTXSID7045526 Clint NA 2.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7045522 TK.Half.Life NA 1.534 hours 1compartment NA NA Rat Human +DTXSID7045522 Css NA 0.2073 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045522 Css NA 1.692 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045522 Css NA 0.1202 mg/L PBTK NA 50% Rat Human +DTXSID7045522 Css NA 0.9602 mg/L PBTK NA 95% Rat Human +DTXSID7045526 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7045526 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7045526 Vd NA 1.109 L/kg 1compartment NA NA Human Human +DTXSID7045526 Vd NA 0.8604 L/kg 1compartment NA NA Human Human DTXSID7045526 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045526 TK.Half.Life NA 2.31 hours 1compartment NA NA Human Human -DTXSID7045526 Css NA 0.2127 mg/L 3compartmentss NA 50% Human Human -DTXSID7045526 Css NA 1.516 mg/L 3compartmentss NA 95% Human Human -DTXSID7045526 Css NA 0.1862 mg/L PBTK NA 50% Human Human -DTXSID7045526 Css NA 1.044 mg/L PBTK NA 95% Human Human -DTXSID7045526 Clint NA 2.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7045526 TK.Half.Life NA 6.436 hours 1compartment NA NA Human Human +DTXSID7045526 Css NA 0.502 mg/L 3compartmentss NA 50% Human Human +DTXSID7045526 Css NA 3.027 mg/L 3compartmentss NA 95% Human Human +DTXSID7045526 Css NA 0.4268 mg/L PBTK NA 50% Human Human +DTXSID7045526 Css NA 2.016 mg/L PBTK NA 95% Human Human +DTXSID7045526 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7045526 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7045526 Vd NA 1.068 L/kg 1compartment NA NA Rat Human +DTXSID7045526 Vd NA 0.873 L/kg 1compartment NA NA Rat Human DTXSID7045526 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045526 TK.Half.Life NA 1.133 hours 1compartment NA NA Rat Human -DTXSID7045526 Css NA 0.08866 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045526 Css NA 0.5591 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045526 Css NA 0.07711 mg/L PBTK NA 50% Rat Human -DTXSID7045526 Css NA 0.3481 mg/L PBTK NA 95% Rat Human -DTXSID7045570 Clint NA 2.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045570 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045570 Vd NA 0.739 L/kg 1compartment NA NA Human Human -DTXSID7045570 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7045570 TK.Half.Life NA 24.77 hours 1compartment NA NA Human Human -DTXSID7045570 Css NA 5.846 mg/L 3compartmentss NA 50% Human Human -DTXSID7045570 Css NA 39.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7045570 Css NA 3.589 mg/L PBTK NA 50% Human Human -DTXSID7045570 Css NA 23.55 mg/L PBTK NA 95% Human Human -DTXSID7045570 Clint NA 2.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045570 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045570 Vd NA 0.5662 L/kg 1compartment NA NA Rat Human -DTXSID7045570 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7045570 TK.Half.Life NA 10.4 hours 1compartment NA NA Rat Human -DTXSID7045570 Css NA 2.857 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045570 Css NA 15.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045570 Css NA 1.629 mg/L PBTK NA 50% Rat Human -DTXSID7045570 Css NA 8.488 mg/L PBTK NA 95% Rat Human -DTXSID7045572 Clint NA 24.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045572 Fup NA 0.0323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045572 Vd NA 1.306 L/kg 1compartment NA NA Human Human +DTXSID7045526 TK.Half.Life NA 2.216 hours 1compartment NA NA Rat Human +DTXSID7045526 Css NA 0.002546 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045526 Css NA 0.01705 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045526 Css NA 0.002123 mg/L PBTK NA 50% Rat Human +DTXSID7045526 Css NA 0.0109 mg/L PBTK NA 95% Rat Human +DTXSID7045570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045570 Fup 0.0611 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045570 Vd NA 0.8939 L/kg 1compartment NA NA Human Human +DTXSID7045570 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7045570 TK.Half.Life NA 3.324 hours 1compartment NA NA Human Human +DTXSID7045570 Css NA 0.4341 mg/L 3compartmentss NA 50% Human Human +DTXSID7045570 Css NA 3.687 mg/L 3compartmentss NA 95% Human Human +DTXSID7045570 Css NA 0.2696 mg/L PBTK NA 50% Human Human +DTXSID7045570 Css NA 2.231 mg/L PBTK NA 95% Human Human +DTXSID7045570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045570 Fup 0.0611 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045570 Vd NA 0.687 L/kg 1compartment NA NA Rat Human +DTXSID7045570 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7045570 TK.Half.Life NA 1.476 hours 1compartment NA NA Rat Human +DTXSID7045570 Css NA 0.0218 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045570 Css NA 0.1918 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045570 Css NA 0.01292 mg/L PBTK NA 50% Rat Human +DTXSID7045570 Css NA 0.1118 mg/L PBTK NA 95% Rat Human +DTXSID7045572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045572 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045572 Vd NA 0.9452 L/kg 1compartment NA NA Human Human DTXSID7045572 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045572 TK.Half.Life NA 7.354 hours 1compartment NA NA Human Human -DTXSID7045572 Css NA 0.84 mg/L 3compartmentss NA 50% Human Human -DTXSID7045572 Css NA 7.264 mg/L 3compartmentss NA 95% Human Human -DTXSID7045572 Css NA 0.5316 mg/L PBTK NA 50% Human Human -DTXSID7045572 Css NA 4.373 mg/L PBTK NA 95% Human Human -DTXSID7045572 Clint NA 24.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045572 Fup NA 0.0323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045572 Vd NA 0.9752 L/kg 1compartment NA NA Rat Human +DTXSID7045572 TK.Half.Life NA 8.876 hours 1compartment NA NA Human Human +DTXSID7045572 Css NA 1.34 mg/L 3compartmentss NA 50% Human Human +DTXSID7045572 Css NA 13.18 mg/L 3compartmentss NA 95% Human Human +DTXSID7045572 Css NA 0.8243 mg/L PBTK NA 50% Human Human +DTXSID7045572 Css NA 7.722 mg/L PBTK NA 95% Human Human +DTXSID7045572 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045572 Fup 0.0185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045572 Vd NA 0.7044 L/kg 1compartment NA NA Rat Human DTXSID7045572 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045572 TK.Half.Life NA 2.975 hours 1compartment NA NA Rat Human -DTXSID7045572 Css NA 0.4704 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045572 Css NA 3.286 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045572 Css NA 0.278 mg/L PBTK NA 50% Rat Human -DTXSID7045572 Css NA 1.85 mg/L PBTK NA 95% Rat Human -DTXSID7045574 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045574 Fup NA 0.5728 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045574 Vd NA 0.3718 L/kg 1compartment NA NA Human Human +DTXSID7045572 TK.Half.Life NA 3.943 hours 1compartment NA NA Rat Human +DTXSID7045572 Css NA 0.06737 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045572 Css NA 0.7107 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045572 Css NA 0.03946 mg/L PBTK NA 50% Rat Human +DTXSID7045572 Css NA 0.4017 mg/L PBTK NA 95% Rat Human +DTXSID7045574 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045574 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045574 Vd NA 0.3778 L/kg 1compartment NA NA Human Human DTXSID7045574 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045574 TK.Half.Life NA 4.198 hours 1compartment NA NA Human Human -DTXSID7045574 Css NA 1.442 mg/L 3compartmentss NA 50% Human Human -DTXSID7045574 Css NA 9.316 mg/L 3compartmentss NA 95% Human Human -DTXSID7045574 Css NA 1.018 mg/L PBTK NA 50% Human Human -DTXSID7045574 Css NA 5.636 mg/L PBTK NA 95% Human Human -DTXSID7045574 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045574 Fup NA 0.5728 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045574 Vd NA 0.3897 L/kg 1compartment NA NA Rat Human +DTXSID7045574 TK.Half.Life NA 7.043 hours 1compartment NA NA Human Human +DTXSID7045574 Css NA 1.199 mg/L 3compartmentss NA 50% Human Human +DTXSID7045574 Css NA 5.209 mg/L 3compartmentss NA 95% Human Human +DTXSID7045574 Css NA 0.8269 mg/L PBTK NA 50% Human Human +DTXSID7045574 Css NA 3.192 mg/L PBTK NA 95% Human Human +DTXSID7045574 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045574 Fup 0.347 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045574 Vd NA 0.391 L/kg 1compartment NA NA Rat Human DTXSID7045574 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045574 TK.Half.Life NA 1.5 hours 1compartment NA NA Rat Human -DTXSID7045574 Css NA 0.3822 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045574 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045574 Css NA 0.2552 mg/L PBTK NA 50% Rat Human -DTXSID7045574 Css NA 1.289 mg/L PBTK NA 95% Rat Human -DTXSID7045576 Clint NA 2.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045576 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045576 Vd NA 0.2049 L/kg 1compartment NA NA Human Human -DTXSID7045576 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7045576 TK.Half.Life NA 22.15 hours 1compartment NA NA Human Human -DTXSID7045576 Css NA 19.8 mg/L 3compartmentss NA 50% Human Human -DTXSID7045576 Css NA 139.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7045576 Css NA 11.66 mg/L PBTK NA 50% Human Human -DTXSID7045576 Css NA 80.64 mg/L PBTK NA 95% Human Human -DTXSID7045576 Clint NA 2.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045576 Fup NA 0.0133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045576 Vd NA 0.196 L/kg 1compartment NA NA Rat Human -DTXSID7045576 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7045576 TK.Half.Life NA 12.01 hours 1compartment NA NA Rat Human -DTXSID7045576 Css NA 9.295 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045576 Css NA 55.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045576 Css NA 5.098 mg/L PBTK NA 50% Rat Human -DTXSID7045576 Css NA 30.12 mg/L PBTK NA 95% Rat Human -DTXSID7045578 Clint NA 0.6303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045578 Fup NA 0.3211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045578 Vd NA 1.56 L/kg 1compartment NA NA Human Human -DTXSID7045578 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7045578 TK.Half.Life NA 15.58 hours 1compartment NA NA Human Human -DTXSID7045578 Css NA 0.9314 mg/L 3compartmentss NA 50% Human Human -DTXSID7045578 Css NA 4.396 mg/L 3compartmentss NA 95% Human Human -DTXSID7045578 Css NA 0.7986 mg/L PBTK NA 50% Human Human -DTXSID7045578 Css NA 3.033 mg/L PBTK NA 95% Human Human -DTXSID7045578 Clint NA 0.6303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045578 Fup NA 0.3211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045578 Vd NA 1.568 L/kg 1compartment NA NA Rat Human +DTXSID7045574 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human +DTXSID7045574 Css NA 0.006462 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045574 Css NA 0.02742 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045574 Css NA 0.004239 mg/L PBTK NA 50% Rat Human +DTXSID7045574 Css NA 0.01641 mg/L PBTK NA 95% Rat Human +DTXSID7045576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045576 Fup 0.044 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045576 Vd NA 0.2897 L/kg 1compartment NA NA Human Human +DTXSID7045576 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7045576 TK.Half.Life NA 1.394 hours 1compartment NA NA Human Human +DTXSID7045576 Css NA 0.686 mg/L 3compartmentss NA 50% Human Human +DTXSID7045576 Css NA 6.362 mg/L 3compartmentss NA 95% Human Human +DTXSID7045576 Css NA 0.4166 mg/L PBTK NA 50% Human Human +DTXSID7045576 Css NA 3.79 mg/L PBTK NA 95% Human Human +DTXSID7045576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045576 Fup 0.044 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045576 Vd NA 0.2727 L/kg 1compartment NA NA Rat Human +DTXSID7045576 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7045576 TK.Half.Life NA 0.8305 hours 1compartment NA NA Rat Human +DTXSID7045576 Css NA 0.09131 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045576 Css NA 0.6183 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045576 Css NA 0.05386 mg/L PBTK NA 50% Rat Human +DTXSID7045576 Css NA 0.3527 mg/L PBTK NA 95% Rat Human +DTXSID7045578 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045578 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045578 Vd NA 2.241 L/kg 1compartment NA NA Human Human +DTXSID7045578 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7045578 TK.Half.Life NA 3.508 hours 1compartment NA NA Human Human +DTXSID7045578 Css NA 0.09808 mg/L 3compartmentss NA 50% Human Human +DTXSID7045578 Css NA 0.8645 mg/L 3compartmentss NA 95% Human Human +DTXSID7045578 Css NA 0.0982 mg/L PBTK NA 50% Human Human +DTXSID7045578 Css NA 0.6723 mg/L PBTK NA 95% Human Human +DTXSID7045578 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045578 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045578 Vd NA 2.267 L/kg 1compartment NA NA Rat Human DTXSID7045578 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045578 TK.Half.Life NA 7.174 hours 1compartment NA NA Rat Human -DTXSID7045578 Css NA 0.3472 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045578 Css NA 1.379 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045578 Css NA 0.2882 mg/L PBTK NA 50% Rat Human -DTXSID7045578 Css NA 0.8816 mg/L PBTK NA 95% Rat Human -DTXSID7045601 Clint NA 37.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045601 Fup NA 0.4957 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045601 Vd NA 3.395 L/kg 1compartment NA NA Human Human +DTXSID7045578 TK.Half.Life NA 2.003 hours 1compartment NA NA Rat Human +DTXSID7045578 Css NA 0.01116 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045578 Css NA 0.07859 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045578 Css NA 0.0115 mg/L PBTK NA 50% Rat Human +DTXSID7045578 Css NA 0.05689 mg/L PBTK NA 95% Rat Human +DTXSID7045601 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045601 Fup 0.074 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045601 Vd NA 1.031 L/kg 1compartment NA NA Human Human DTXSID7045601 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045601 TK.Half.Life NA 5.532 hours 1compartment NA NA Human Human -DTXSID7045601 Css NA 0.1019 mg/L 3compartmentss NA 50% Human Human -DTXSID7045601 Css NA 0.6551 mg/L 3compartmentss NA 95% Human Human -DTXSID7045601 Css NA 0.07604 mg/L PBTK NA 50% Human Human -DTXSID7045601 Css NA 0.4613 mg/L PBTK NA 95% Human Human -DTXSID7045601 Clint NA 37.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045601 Fup NA 0.4957 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045601 Vd NA 2.639 L/kg 1compartment NA NA Rat Human +DTXSID7045601 TK.Half.Life NA 8.138 hours 1compartment NA NA Human Human +DTXSID7045601 Css NA 1.107 mg/L 3compartmentss NA 50% Human Human +DTXSID7045601 Css NA 7.959 mg/L 3compartmentss NA 95% Human Human +DTXSID7045601 Css NA 0.7528 mg/L PBTK NA 50% Human Human +DTXSID7045601 Css NA 4.876 mg/L PBTK NA 95% Human Human +DTXSID7045601 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045601 Fup 0.074 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045601 Vd NA 1.016 L/kg 1compartment NA NA Rat Human DTXSID7045601 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045601 TK.Half.Life NA 1.27 hours 1compartment NA NA Rat Human -DTXSID7045601 Css NA 0.05615 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045601 Css NA 0.3003 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045601 Css NA 0.04018 mg/L PBTK NA 50% Rat Human -DTXSID7045601 Css NA 0.2089 mg/L PBTK NA 95% Rat Human -DTXSID7045603 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045603 Fup NA 0.7925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045603 Vd NA 0.7123 L/kg 1compartment NA NA Human Human +DTXSID7045601 TK.Half.Life NA 4.976 hours 1compartment NA NA Rat Human +DTXSID7045601 Css NA 0.1356 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045601 Css NA 0.7515 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045601 Css NA 0.08969 mg/L PBTK NA 50% Rat Human +DTXSID7045601 Css NA 0.4478 mg/L PBTK NA 95% Rat Human +DTXSID7045603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045603 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045603 Vd NA 0.545 L/kg 1compartment NA NA Human Human DTXSID7045603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045603 TK.Half.Life NA 5.879 hours 1compartment NA NA Human Human -DTXSID7045603 Css NA 1.024 mg/L 3compartmentss NA 50% Human Human -DTXSID7045603 Css NA 6.325 mg/L 3compartmentss NA 95% Human Human -DTXSID7045603 Css NA 0.8242 mg/L PBTK NA 50% Human Human -DTXSID7045603 Css NA 4.003 mg/L PBTK NA 95% Human Human -DTXSID7045603 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045603 Fup NA 0.7925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045603 Vd NA 0.6969 L/kg 1compartment NA NA Rat Human +DTXSID7045603 TK.Half.Life NA 7.578 hours 1compartment NA NA Human Human +DTXSID7045603 Css NA 0.8438 mg/L 3compartmentss NA 50% Human Human +DTXSID7045603 Css NA 4.195 mg/L 3compartmentss NA 95% Human Human +DTXSID7045603 Css NA 0.6265 mg/L PBTK NA 50% Human Human +DTXSID7045603 Css NA 2.681 mg/L PBTK NA 95% Human Human +DTXSID7045603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045603 Fup 0.469 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045603 Vd NA 0.5284 L/kg 1compartment NA NA Rat Human DTXSID7045603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045603 TK.Half.Life NA 1.944 hours 1compartment NA NA Rat Human -DTXSID7045603 Css NA 0.2631 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045603 Css NA 1.536 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045603 Css NA 0.2044 mg/L PBTK NA 50% Rat Human -DTXSID7045603 Css NA 0.911 mg/L PBTK NA 95% Rat Human -DTXSID7045605 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045605 Fup NA 0.6299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045605 Vd NA 0.7075 L/kg 1compartment NA NA Human Human -DTXSID7045605 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045605 TK.Half.Life NA 0.6633 hours 1compartment NA NA Human Human -DTXSID7045605 Css NA 0.04227 mg/L 3compartmentss NA 50% Human Human -DTXSID7045605 Css NA 0.4299 mg/L 3compartmentss NA 95% Human Human -DTXSID7045605 Css NA 0.03324 mg/L PBTK NA 50% Human Human -DTXSID7045605 Css NA 0.2926 mg/L PBTK NA 95% Human Human -DTXSID7045605 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045605 Fup NA 0.6299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045605 Vd NA 0.7163 L/kg 1compartment NA NA Rat Human -DTXSID7045605 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045605 TK.Half.Life NA 0.3363 hours 1compartment NA NA Rat Human -DTXSID7045605 Css NA 0.02116 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045605 Css NA 0.1857 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045605 Css NA 0.01645 mg/L PBTK NA 50% Rat Human -DTXSID7045605 Css NA 0.119 mg/L PBTK NA 95% Rat Human -DTXSID7045607 Clint NA 10.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045607 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045607 Vd NA 0.5821 L/kg 1compartment NA NA Human Human -DTXSID7045607 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7045607 TK.Half.Life NA 13.97 hours 1compartment NA NA Human Human -DTXSID7045607 Css NA 4.382 mg/L 3compartmentss NA 50% Human Human -DTXSID7045607 Css NA 38.2 mg/L 3compartmentss NA 95% Human Human -DTXSID7045607 Css NA 2.609 mg/L PBTK NA 50% Human Human -DTXSID7045607 Css NA 21.91 mg/L PBTK NA 95% Human Human -DTXSID7045607 Clint NA 10.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045607 Fup NA 0.0134 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045607 Vd NA 0.4404 L/kg 1compartment NA NA Rat Human +DTXSID7045603 TK.Half.Life NA 2.488 hours 1compartment NA NA Rat Human +DTXSID7045603 Css NA 0.004564 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045603 Css NA 0.02297 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045603 Css NA 0.003236 mg/L PBTK NA 50% Rat Human +DTXSID7045603 Css NA 0.01418 mg/L PBTK NA 95% Rat Human +DTXSID7045607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045607 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045607 Vd NA 0.5016 L/kg 1compartment NA NA Human Human +DTXSID7045607 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7045607 TK.Half.Life NA 1.026 hours 1compartment NA NA Human Human +DTXSID7045607 Css NA 0.1833 mg/L 3compartmentss NA 50% Human Human +DTXSID7045607 Css NA 1.612 mg/L 3compartmentss NA 95% Human Human +DTXSID7045607 Css NA 0.1238 mg/L PBTK NA 50% Human Human +DTXSID7045607 Css NA 0.9952 mg/L PBTK NA 95% Human Human +DTXSID7045607 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045607 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045607 Vd NA 0.4656 L/kg 1compartment NA NA Rat Human DTXSID7045607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045607 TK.Half.Life NA 6.691 hours 1compartment NA NA Rat Human -DTXSID7045607 Css NA 2.418 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045607 Css NA 17.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045607 Css NA 1.344 mg/L PBTK NA 50% Rat Human -DTXSID7045607 Css NA 9.285 mg/L PBTK NA 95% Rat Human -DTXSID7045651 Clint NA 0.9186 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045651 Fup NA 0.4245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045651 Vd NA 3.126 L/kg 1compartment NA NA Human Human -DTXSID7045651 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7045651 TK.Half.Life NA 18.89 hours 1compartment NA NA Human Human -DTXSID7045651 Css NA 0.4308 mg/L 3compartmentss NA 50% Human Human -DTXSID7045651 Css NA 2.736 mg/L 3compartmentss NA 95% Human Human -DTXSID7045651 Css NA 0.5004 mg/L PBTK NA 50% Human Human -DTXSID7045651 Css NA 2.167 mg/L PBTK NA 95% Human Human -DTXSID7045651 Clint NA 0.9186 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045651 Fup NA 0.4245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045651 Vd NA 3.174 L/kg 1compartment NA NA Rat Human +DTXSID7045607 TK.Half.Life NA 0.5492 hours 1compartment NA NA Rat Human +DTXSID7045607 Css NA 0.02396 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045607 Css NA 0.1557 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045607 Css NA 0.01572 mg/L PBTK NA 50% Rat Human +DTXSID7045607 Css NA 0.09313 mg/L PBTK NA 95% Rat Human +DTXSID7045651 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045651 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045651 Vd NA 2.682 L/kg 1compartment NA NA Human Human +DTXSID7045651 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7045651 TK.Half.Life NA 4.191 hours 1compartment NA NA Human Human +DTXSID7045651 Css NA 0.09401 mg/L 3compartmentss NA 50% Human Human +DTXSID7045651 Css NA 0.7933 mg/L 3compartmentss NA 95% Human Human +DTXSID7045651 Css NA 0.1019 mg/L PBTK NA 50% Human Human +DTXSID7045651 Css NA 0.6374 mg/L PBTK NA 95% Human Human +DTXSID7045651 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045651 Fup 0.48 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045651 Vd NA 2.717 L/kg 1compartment NA NA Rat Human DTXSID7045651 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045651 TK.Half.Life NA 9.374 hours 1compartment NA NA Rat Human -DTXSID7045651 Css NA 0.1657 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045651 Css NA 0.9063 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045651 Css NA 0.191 mg/L PBTK NA 50% Rat Human -DTXSID7045651 Css NA 0.6667 mg/L PBTK NA 95% Rat Human -DTXSID7045653 Clint NA 77.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045653 Fup NA 0.0849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045653 Vd NA 2.853 L/kg 1compartment NA NA Human Human +DTXSID7045651 TK.Half.Life NA 2.424 hours 1compartment NA NA Rat Human +DTXSID7045651 Css NA 0.01046 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045651 Css NA 0.0765 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045651 Css NA 0.01165 mg/L PBTK NA 50% Rat Human +DTXSID7045651 Css NA 0.05751 mg/L PBTK NA 95% Rat Human +DTXSID7045653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045653 Fup 0.0723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045653 Vd NA 1.011 L/kg 1compartment NA NA Human Human DTXSID7045653 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045653 TK.Half.Life NA 7.46 hours 1compartment NA NA Human Human -DTXSID7045653 Css NA 0.2447 mg/L 3compartmentss NA 50% Human Human -DTXSID7045653 Css NA 1.663 mg/L 3compartmentss NA 95% Human Human -DTXSID7045653 Css NA 0.1692 mg/L PBTK NA 50% Human Human -DTXSID7045653 Css NA 1.104 mg/L PBTK NA 95% Human Human -DTXSID7045653 Clint NA 77.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045653 Fup NA 0.0849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045653 Vd NA 2.154 L/kg 1compartment NA NA Rat Human +DTXSID7045653 TK.Half.Life NA 3.353 hours 1compartment NA NA Human Human +DTXSID7045653 Css NA 0.398 mg/L 3compartmentss NA 50% Human Human +DTXSID7045653 Css NA 3.165 mg/L 3compartmentss NA 95% Human Human +DTXSID7045653 Css NA 0.256 mg/L PBTK NA 50% Human Human +DTXSID7045653 Css NA 1.941 mg/L PBTK NA 95% Human Human +DTXSID7045653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045653 Fup 0.0723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045653 Vd NA 0.7768 L/kg 1compartment NA NA Rat Human DTXSID7045653 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045653 TK.Half.Life NA 1.74 hours 1compartment NA NA Rat Human -DTXSID7045653 Css NA 0.1352 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045653 Css NA 0.7364 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045653 Css NA 0.08988 mg/L PBTK NA 50% Rat Human -DTXSID7045653 Css NA 0.4836 mg/L PBTK NA 95% Rat Human -DTXSID7045655 Clint NA 0.1283 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045655 Fup NA 0.0701 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045655 Vd NA 0.2888 L/kg 1compartment NA NA Human Human -DTXSID7045655 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7045655 TK.Half.Life NA 21.97 hours 1compartment NA NA Human Human -DTXSID7045655 Css NA 12.07 mg/L 3compartmentss NA 50% Human Human -DTXSID7045655 Css NA 52.84 mg/L 3compartmentss NA 95% Human Human -DTXSID7045655 Css NA 7.364 mg/L PBTK NA 50% Human Human -DTXSID7045655 Css NA 30.62 mg/L PBTK NA 95% Human Human -DTXSID7045655 Clint NA 0.1283 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045655 Fup NA 0.0701 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045655 Vd NA 0.2866 L/kg 1compartment NA NA Rat Human +DTXSID7045653 TK.Half.Life NA 1.447 hours 1compartment NA NA Rat Human +DTXSID7045653 Css NA 0.05232 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045653 Css NA 0.3132 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045653 Css NA 0.03266 mg/L PBTK NA 50% Rat Human +DTXSID7045653 Css NA 0.1855 mg/L PBTK NA 95% Rat Human +DTXSID7045655 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045655 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045655 Vd NA 0.4026 L/kg 1compartment NA NA Human Human +DTXSID7045655 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7045655 TK.Half.Life NA 2.034 hours 1compartment NA NA Human Human +DTXSID7045655 Css NA 0.6506 mg/L 3compartmentss NA 50% Human Human +DTXSID7045655 Css NA 4.74 mg/L 3compartmentss NA 95% Human Human +DTXSID7045655 Css NA 0.4242 mg/L PBTK NA 50% Human Human +DTXSID7045655 Css NA 2.866 mg/L PBTK NA 95% Human Human +DTXSID7045655 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045655 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045655 Vd NA 0.4 L/kg 1compartment NA NA Rat Human DTXSID7045655 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045655 TK.Half.Life NA 8.168 hours 1compartment NA NA Rat Human -DTXSID7045655 Css NA 3.806 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045655 Css NA 14.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045655 Css NA 2.181 mg/L PBTK NA 50% Rat Human -DTXSID7045655 Css NA 7.846 mg/L PBTK NA 95% Rat Human -DTXSID7045659 Clint NA 47.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045659 Fup NA 0.427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045659 Vd NA 2.9 L/kg 1compartment NA NA Human Human -DTXSID7045659 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045659 TK.Half.Life NA 4.443 hours 1compartment NA NA Human Human -DTXSID7045659 Css NA 0.09454 mg/L 3compartmentss NA 50% Human Human -DTXSID7045659 Css NA 0.6107 mg/L 3compartmentss NA 95% Human Human -DTXSID7045659 Css NA 0.07106 mg/L PBTK NA 50% Human Human -DTXSID7045659 Css NA 0.4355 mg/L PBTK NA 95% Human Human -DTXSID7045659 Clint NA 47.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045659 Fup NA 0.427 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045659 Vd NA 2.219 L/kg 1compartment NA NA Rat Human -DTXSID7045659 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045659 TK.Half.Life NA 1.143 hours 1compartment NA NA Rat Human -DTXSID7045659 Css NA 0.05182 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045659 Css NA 0.27 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045659 Css NA 0.03769 mg/L PBTK NA 50% Rat Human -DTXSID7045659 Css NA 0.186 mg/L PBTK NA 95% Rat Human -DTXSID7045780 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045780 Fup NA 0.9747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045780 Vd NA 0.8026 L/kg 1compartment NA NA Human Human +DTXSID7045655 TK.Half.Life NA 1.219 hours 1compartment NA NA Rat Human +DTXSID7045655 Css NA 0.0798 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045655 Css NA 0.4249 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045655 Css NA 0.05044 mg/L PBTK NA 50% Rat Human +DTXSID7045655 Css NA 0.249 mg/L PBTK NA 95% Rat Human +DTXSID7045659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045659 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045659 Vd NA 3.043 L/kg 1compartment NA NA Human Human +DTXSID7045659 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7045659 TK.Half.Life NA 25.67 hours 1compartment NA NA Human Human +DTXSID7045659 Css NA 0.9108 mg/L 3compartmentss NA 50% Human Human +DTXSID7045659 Css NA 5.725 mg/L 3compartmentss NA 95% Human Human +DTXSID7045659 Css NA 0.6402 mg/L PBTK NA 50% Human Human +DTXSID7045659 Css NA 3.964 mg/L PBTK NA 95% Human Human +DTXSID7045659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045659 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045659 Vd NA 2.289 L/kg 1compartment NA NA Rat Human +DTXSID7045659 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7045659 TK.Half.Life NA 4.214 hours 1compartment NA NA Rat Human +DTXSID7045659 Css NA 0.1166 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045659 Css NA 0.6032 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045659 Css NA 0.0817 mg/L PBTK NA 50% Rat Human +DTXSID7045659 Css NA 0.4126 mg/L PBTK NA 95% Rat Human +DTXSID7045780 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045780 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045780 Vd NA 0.5945 L/kg 1compartment NA NA Human Human DTXSID7045780 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045780 TK.Half.Life NA 5.332 hours 1compartment NA NA Human Human -DTXSID7045780 Css NA 0.8737 mg/L 3compartmentss NA 50% Human Human -DTXSID7045780 Css NA 5.042 mg/L 3compartmentss NA 95% Human Human -DTXSID7045780 Css NA 0.7346 mg/L PBTK NA 50% Human Human -DTXSID7045780 Css NA 3.292 mg/L PBTK NA 95% Human Human -DTXSID7045780 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045780 Fup NA 0.9747 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045780 Vd NA 0.8347 L/kg 1compartment NA NA Rat Human +DTXSID7045780 TK.Half.Life NA 5.419 hours 1compartment NA NA Human Human +DTXSID7045780 Css NA 0.6085 mg/L 3compartmentss NA 50% Human Human +DTXSID7045780 Css NA 3.993 mg/L 3compartmentss NA 95% Human Human +DTXSID7045780 Css NA 0.4775 mg/L PBTK NA 50% Human Human +DTXSID7045780 Css NA 2.55 mg/L PBTK NA 95% Human Human +DTXSID7045780 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045780 Fup 0.71 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045780 Vd NA 0.6307 L/kg 1compartment NA NA Rat Human DTXSID7045780 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045780 TK.Half.Life NA 1.889 hours 1compartment NA NA Rat Human -DTXSID7045780 Css NA 0.2217 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045780 Css NA 1.208 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045780 Css NA 0.182 mg/L PBTK NA 50% Rat Human -DTXSID7045780 Css NA 0.7361 mg/L PBTK NA 95% Rat Human -DTXSID7045782 Clint NA 220.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045782 Fup NA 0.8212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045782 Vd NA 3.412 L/kg 1compartment NA NA Human Human -DTXSID7045782 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045782 TK.Half.Life NA 1.365 hours 1compartment NA NA Human Human -DTXSID7045782 Css NA 0.001942 mg/L 3compartmentss NA 50% Human Human -DTXSID7045782 Css NA 0.02474 mg/L 3compartmentss NA 95% Human Human -DTXSID7045782 Css NA 0.002318 mg/L PBTK NA 50% Human Human -DTXSID7045782 Css NA 0.02179 mg/L PBTK NA 95% Human Human -DTXSID7045782 Clint NA 220.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045782 Fup NA 0.8212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045782 Vd NA 3.477 L/kg 1compartment NA NA Rat Human +DTXSID7045780 TK.Half.Life NA 1.959 hours 1compartment NA NA Rat Human +DTXSID7045780 Css NA 0.003134 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045780 Css NA 0.02144 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045780 Css NA 0.002394 mg/L PBTK NA 50% Rat Human +DTXSID7045780 Css NA 0.01292 mg/L PBTK NA 95% Rat Human +DTXSID7045782 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045782 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045782 Vd NA 1.905 L/kg 1compartment NA NA Human Human +DTXSID7045782 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7045782 TK.Half.Life NA 19.69 hours 1compartment NA NA Human Human +DTXSID7045782 Css NA 0.9395 mg/L 3compartmentss NA 50% Human Human +DTXSID7045782 Css NA 7.223 mg/L 3compartmentss NA 95% Human Human +DTXSID7045782 Css NA 0.9288 mg/L PBTK NA 50% Human Human +DTXSID7045782 Css NA 4.89 mg/L PBTK NA 95% Human Human +DTXSID7045782 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045782 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045782 Vd NA 1.929 L/kg 1compartment NA NA Rat Human DTXSID7045782 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045782 TK.Half.Life NA 0.6183 hours 1compartment NA NA Rat Human -DTXSID7045782 Css NA 0.0009867 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045782 Css NA 0.01215 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045782 Css NA 0.00122 mg/L PBTK NA 50% Rat Human -DTXSID7045782 Css NA 0.01067 mg/L PBTK NA 95% Rat Human -DTXSID7045786 Clint NA 7.079 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045786 Fup NA 0.0605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045786 Vd NA 0.2175 L/kg 1compartment NA NA Human Human +DTXSID7045782 TK.Half.Life NA 6.796 hours 1compartment NA NA Rat Human +DTXSID7045782 Css NA 0.05615 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045782 Css NA 0.4167 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045782 Css NA 0.05624 mg/L PBTK NA 50% Rat Human +DTXSID7045782 Css NA 0.2714 mg/L PBTK NA 95% Rat Human +DTXSID7045786 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045786 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045786 Vd NA 0.3496 L/kg 1compartment NA NA Human Human DTXSID7045786 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045786 TK.Half.Life NA 2.005 hours 1compartment NA NA Human Human -DTXSID7045786 Css NA 1.54 mg/L 3compartmentss NA 50% Human Human -DTXSID7045786 Css NA 9.998 mg/L 3compartmentss NA 95% Human Human -DTXSID7045786 Css NA 0.9186 mg/L PBTK NA 50% Human Human -DTXSID7045786 Css NA 5.888 mg/L PBTK NA 95% Human Human -DTXSID7045786 Clint NA 7.079 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045786 Fup NA 0.0605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045786 Vd NA 0.215 L/kg 1compartment NA NA Rat Human +DTXSID7045786 TK.Half.Life NA 0.5576 hours 1compartment NA NA Human Human +DTXSID7045786 Css NA 0.1006 mg/L 3compartmentss NA 50% Human Human +DTXSID7045786 Css NA 0.7344 mg/L 3compartmentss NA 95% Human Human +DTXSID7045786 Css NA 0.0664 mg/L PBTK NA 50% Human Human +DTXSID7045786 Css NA 0.4551 mg/L PBTK NA 95% Human Human +DTXSID7045786 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045786 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045786 Vd NA 0.3461 L/kg 1compartment NA NA Rat Human DTXSID7045786 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045786 TK.Half.Life NA 1.237 hours 1compartment NA NA Rat Human -DTXSID7045786 Css NA 0.8217 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045786 Css NA 3.937 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045786 Css NA 0.4576 mg/L PBTK NA 50% Rat Human -DTXSID7045786 Css NA 2.161 mg/L PBTK NA 95% Rat Human -DTXSID7045788 Clint NA 33.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045788 Fup NA 0.2959 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045788 Vd NA 1.07 L/kg 1compartment NA NA Human Human -DTXSID7045788 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045788 TK.Half.Life NA 1.115 hours 1compartment NA NA Human Human -DTXSID7045788 Css NA 0.04172 mg/L 3compartmentss NA 50% Human Human -DTXSID7045788 Css NA 0.3297 mg/L 3compartmentss NA 95% Human Human -DTXSID7045788 Css NA 0.03323 mg/L PBTK NA 50% Human Human -DTXSID7045788 Css NA 0.2329 mg/L PBTK NA 95% Human Human -DTXSID7045788 Clint NA 33.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045788 Fup NA 0.2959 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045788 Vd NA 1.048 L/kg 1compartment NA NA Rat Human +DTXSID7045786 TK.Half.Life NA 0.3019 hours 1compartment NA NA Rat Human +DTXSID7045786 Css NA 0.01286 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045786 Css NA 0.07108 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045786 Css NA 0.008303 mg/L PBTK NA 50% Rat Human +DTXSID7045786 Css NA 0.04371 mg/L PBTK NA 95% Rat Human +DTXSID7045788 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045788 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045788 Vd NA 2.02 L/kg 1compartment NA NA Human Human +DTXSID7045788 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7045788 TK.Half.Life NA 24.85 hours 1compartment NA NA Human Human +DTXSID7045788 Css NA 1.012 mg/L 3compartmentss NA 50% Human Human +DTXSID7045788 Css NA 6.901 mg/L 3compartmentss NA 95% Human Human +DTXSID7045788 Css NA 1.042 mg/L PBTK NA 50% Human Human +DTXSID7045788 Css NA 4.818 mg/L PBTK NA 95% Human Human +DTXSID7045788 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045788 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045788 Vd NA 2.005 L/kg 1compartment NA NA Rat Human DTXSID7045788 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045788 TK.Half.Life NA 0.5645 hours 1compartment NA NA Rat Human -DTXSID7045788 Css NA 0.02294 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045788 Css NA 0.137 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045788 Css NA 0.01746 mg/L PBTK NA 50% Rat Human -DTXSID7045788 Css NA 0.09485 mg/L PBTK NA 95% Rat Human -DTXSID7045811 Clint NA 66.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045811 Fup NA 0.0354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045811 Vd NA 3.12 L/kg 1compartment NA NA Human Human +DTXSID7045788 TK.Half.Life NA 8.403 hours 1compartment NA NA Rat Human +DTXSID7045788 Css NA 0.06066 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045788 Css NA 0.4058 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045788 Css NA 0.06368 mg/L PBTK NA 50% Rat Human +DTXSID7045788 Css NA 0.2732 mg/L PBTK NA 95% Rat Human +DTXSID7045811 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045811 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045811 Vd NA 0.8028 L/kg 1compartment NA NA Human Human DTXSID7045811 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045811 TK.Half.Life NA 2.94 hours 1compartment NA NA Human Human -DTXSID7045811 Css NA 0.03398 mg/L 3compartmentss NA 50% Human Human -DTXSID7045811 Css NA 0.2591 mg/L 3compartmentss NA 95% Human Human -DTXSID7045811 Css NA 0.02675 mg/L PBTK NA 50% Human Human -DTXSID7045811 Css NA 0.1892 mg/L PBTK NA 95% Human Human -DTXSID7045811 Clint NA 66.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045811 Fup NA 0.0354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045811 Vd NA 2.665 L/kg 1compartment NA NA Rat Human +DTXSID7045811 TK.Half.Life NA 1.47 hours 1compartment NA NA Human Human +DTXSID7045811 Css NA 0.1394 mg/L 3compartmentss NA 50% Human Human +DTXSID7045811 Css NA 1.07 mg/L 3compartmentss NA 95% Human Human +DTXSID7045811 Css NA 0.09608 mg/L PBTK NA 50% Human Human +DTXSID7045811 Css NA 0.6849 mg/L PBTK NA 95% Human Human +DTXSID7045811 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045811 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045811 Vd NA 0.7981 L/kg 1compartment NA NA Rat Human DTXSID7045811 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045811 TK.Half.Life NA 1.076 hours 1compartment NA NA Rat Human -DTXSID7045811 Css NA 0.01865 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045811 Css NA 0.1143 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045811 Css NA 0.01431 mg/L PBTK NA 50% Rat Human -DTXSID7045811 Css NA 0.08074 mg/L PBTK NA 95% Rat Human -DTXSID7045813 Clint NA 4.551 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045813 Fup NA 0.0866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045813 Vd NA 0.2887 L/kg 1compartment NA NA Human Human +DTXSID7045811 TK.Half.Life NA 0.8345 hours 1compartment NA NA Rat Human +DTXSID7045811 Css NA 0.01802 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045811 Css NA 0.1038 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045811 Css NA 0.01222 mg/L PBTK NA 50% Rat Human +DTXSID7045811 Css NA 0.06625 mg/L PBTK NA 95% Rat Human +DTXSID7045813 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045813 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045813 Vd NA 0.4677 L/kg 1compartment NA NA Human Human DTXSID7045813 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045813 TK.Half.Life NA 2.726 hours 1compartment NA NA Human Human -DTXSID7045813 Css NA 1.497 mg/L 3compartmentss NA 50% Human Human -DTXSID7045813 Css NA 9.637 mg/L 3compartmentss NA 95% Human Human -DTXSID7045813 Css NA 0.9125 mg/L PBTK NA 50% Human Human -DTXSID7045813 Css NA 5.669 mg/L PBTK NA 95% Human Human -DTXSID7045813 Clint NA 4.551 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045813 Fup NA 0.0866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045813 Vd NA 0.2772 L/kg 1compartment NA NA Rat Human +DTXSID7045813 TK.Half.Life NA 1.592 hours 1compartment NA NA Human Human +DTXSID7045813 Css NA 0.3342 mg/L 3compartmentss NA 50% Human Human +DTXSID7045813 Css NA 2.064 mg/L 3compartmentss NA 95% Human Human +DTXSID7045813 Css NA 0.2242 mg/L PBTK NA 50% Human Human +DTXSID7045813 Css NA 1.309 mg/L PBTK NA 95% Human Human +DTXSID7045813 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045813 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045813 Vd NA 0.451 L/kg 1compartment NA NA Rat Human DTXSID7045813 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045813 TK.Half.Life NA 1.577 hours 1compartment NA NA Rat Human -DTXSID7045813 Css NA 0.7802 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045813 Css NA 3.784 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045813 Css NA 0.4444 mg/L PBTK NA 50% Rat Human -DTXSID7045813 Css NA 2.082 mg/L PBTK NA 95% Rat Human -DTXSID7045815 Clint NA 5.631 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045815 Fup NA 0.1274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045815 Vd NA 2.083 L/kg 1compartment NA NA Human Human +DTXSID7045813 TK.Half.Life NA 0.8962 hours 1compartment NA NA Rat Human +DTXSID7045813 Css NA 0.04025 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045813 Css NA 0.1746 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045813 Css NA 0.02654 mg/L PBTK NA 50% Rat Human +DTXSID7045813 Css NA 0.1058 mg/L PBTK NA 95% Rat Human +DTXSID7045815 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045815 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045815 Vd NA 2.733 L/kg 1compartment NA NA Human Human DTXSID7045815 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045815 TK.Half.Life NA 12.43 hours 1compartment NA NA Human Human -DTXSID7045815 Css NA 0.7207 mg/L 3compartmentss NA 50% Human Human -DTXSID7045815 Css NA 4.787 mg/L 3compartmentss NA 95% Human Human -DTXSID7045815 Css NA 0.542 mg/L PBTK NA 50% Human Human -DTXSID7045815 Css NA 3.225 mg/L PBTK NA 95% Human Human -DTXSID7045815 Clint NA 5.631 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045815 Fup NA 0.1274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045815 Vd NA 1.823 L/kg 1compartment NA NA Rat Human +DTXSID7045815 TK.Half.Life NA 9.042 hours 1compartment NA NA Human Human +DTXSID7045815 Css NA 0.2694 mg/L 3compartmentss NA 50% Human Human +DTXSID7045815 Css NA 1.602 mg/L 3compartmentss NA 95% Human Human +DTXSID7045815 Css NA 0.2394 mg/L PBTK NA 50% Human Human +DTXSID7045815 Css NA 1.242 mg/L PBTK NA 95% Human Human +DTXSID7045815 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045815 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045815 Vd NA 2.453 L/kg 1compartment NA NA Rat Human DTXSID7045815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045815 TK.Half.Life NA 5.59 hours 1compartment NA NA Rat Human -DTXSID7045815 Css NA 0.3695 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045815 Css NA 1.873 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045815 Css NA 0.269 mg/L PBTK NA 50% Rat Human -DTXSID7045815 Css NA 1.153 mg/L PBTK NA 95% Rat Human -DTXSID7045861 Clint NA 9.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045861 Fup NA 0.3543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045861 Vd NA 0.5333 L/kg 1compartment NA NA Human Human +DTXSID7045815 TK.Half.Life NA 3.853 hours 1compartment NA NA Rat Human +DTXSID7045815 Css NA 0.0312 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045815 Css NA 0.1398 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045815 Css NA 0.02816 mg/L PBTK NA 50% Rat Human +DTXSID7045815 Css NA 0.1069 mg/L PBTK NA 95% Rat Human +DTXSID7045861 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045861 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045861 Vd NA 0.6215 L/kg 1compartment NA NA Human Human DTXSID7045861 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045861 TK.Half.Life NA 0.926 hours 1compartment NA NA Human Human -DTXSID7045861 Css NA 0.129 mg/L 3compartmentss NA 50% Human Human -DTXSID7045861 Css NA 0.8598 mg/L 3compartmentss NA 95% Human Human -DTXSID7045861 Css NA 0.09264 mg/L PBTK NA 50% Human Human -DTXSID7045861 Css NA 0.5622 mg/L PBTK NA 95% Human Human -DTXSID7045861 Clint NA 9.794 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045861 Fup NA 0.3543 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045861 Vd NA 0.5359 L/kg 1compartment NA NA Rat Human +DTXSID7045861 TK.Half.Life NA 1.332 hours 1compartment NA NA Human Human +DTXSID7045861 Css NA 0.15 mg/L 3compartmentss NA 50% Human Human +DTXSID7045861 Css NA 1.037 mg/L 3compartmentss NA 95% Human Human +DTXSID7045861 Css NA 0.1104 mg/L PBTK NA 50% Human Human +DTXSID7045861 Css NA 0.6958 mg/L PBTK NA 95% Human Human +DTXSID7045861 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045861 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045861 Vd NA 0.6097 L/kg 1compartment NA NA Rat Human DTXSID7045861 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045861 TK.Half.Life NA 0.5154 hours 1compartment NA NA Rat Human -DTXSID7045861 Css NA 0.06765 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045861 Css NA 0.3461 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045861 Css NA 0.04633 mg/L PBTK NA 50% Rat Human -DTXSID7045861 Css NA 0.214 mg/L PBTK NA 95% Rat Human -DTXSID7045863 Clint NA 6.649 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045863 Fup NA 0.0938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045863 Vd NA 3.089 L/kg 1compartment NA NA Human Human -DTXSID7045863 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID7045863 TK.Half.Life NA 99.08 hours 1compartment NA NA Human Human -DTXSID7045863 Css NA 3.933 mg/L 3compartmentss NA 50% Human Human -DTXSID7045863 Css NA 23.4 mg/L 3compartmentss NA 95% Human Human -DTXSID7045863 Css NA 2.777 mg/L PBTK NA 50% Human Human -DTXSID7045863 Css NA 15.76 mg/L PBTK NA 95% Human Human -DTXSID7045863 Clint NA 6.649 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045863 Fup NA 0.0938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045863 Vd NA 2.344 L/kg 1compartment NA NA Rat Human -DTXSID7045863 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID7045863 TK.Half.Life NA 15.24 hours 1compartment NA NA Rat Human -DTXSID7045863 Css NA 2.136 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045863 Css NA 9.217 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045863 Css NA 1.449 mg/L PBTK NA 50% Rat Human -DTXSID7045863 Css NA 5.934 mg/L PBTK NA 95% Rat Human -DTXSID7045865 Clint NA 28.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045865 Fup NA 0.0108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045865 Vd NA 0.4243 L/kg 1compartment NA NA Human Human +DTXSID7045861 TK.Half.Life NA 0.7318 hours 1compartment NA NA Rat Human +DTXSID7045861 Css NA 0.00646 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045861 Css NA 0.05077 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045861 Css NA 0.00479 mg/L PBTK NA 50% Rat Human +DTXSID7045861 Css NA 0.0329 mg/L PBTK NA 95% Rat Human +DTXSID7045863 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045863 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045863 Vd NA 0.3124 L/kg 1compartment NA NA Human Human +DTXSID7045863 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7045863 TK.Half.Life NA 1.137 hours 1compartment NA NA Human Human +DTXSID7045863 Css NA 0.3758 mg/L 3compartmentss NA 50% Human Human +DTXSID7045863 Css NA 2.28 mg/L 3compartmentss NA 95% Human Human +DTXSID7045863 Css NA 0.2391 mg/L PBTK NA 50% Human Human +DTXSID7045863 Css NA 1.381 mg/L PBTK NA 95% Human Human +DTXSID7045863 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045863 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045863 Vd NA 0.3134 L/kg 1compartment NA NA Rat Human +DTXSID7045863 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7045863 TK.Half.Life NA 0.6691 hours 1compartment NA NA Rat Human +DTXSID7045863 Css NA 0.04583 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045863 Css NA 0.1923 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045863 Css NA 0.02856 mg/L PBTK NA 50% Rat Human +DTXSID7045863 Css NA 0.1141 mg/L PBTK NA 95% Rat Human +DTXSID7045865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045865 Fup 0.0418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045865 Vd NA 0.8272 L/kg 1compartment NA NA Human Human DTXSID7045865 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045865 TK.Half.Life NA 5.157 hours 1compartment NA NA Human Human -DTXSID7045865 Css NA 2.134 mg/L 3compartmentss NA 50% Human Human -DTXSID7045865 Css NA 21.18 mg/L 3compartmentss NA 95% Human Human -DTXSID7045865 Css NA 1.258 mg/L PBTK NA 50% Human Human -DTXSID7045865 Css NA 12.35 mg/L PBTK NA 95% Human Human -DTXSID7045865 Clint NA 28.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045865 Fup NA 0.0108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045865 Vd NA 0.3326 L/kg 1compartment NA NA Rat Human +DTXSID7045865 TK.Half.Life NA 4.075 hours 1compartment NA NA Human Human +DTXSID7045865 Css NA 0.7304 mg/L 3compartmentss NA 50% Human Human +DTXSID7045865 Css NA 5.545 mg/L 3compartmentss NA 95% Human Human +DTXSID7045865 Css NA 0.4476 mg/L PBTK NA 50% Human Human +DTXSID7045865 Css NA 3.328 mg/L PBTK NA 95% Human Human +DTXSID7045865 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045865 Fup 0.0418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045865 Vd NA 0.6354 L/kg 1compartment NA NA Rat Human DTXSID7045865 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045865 TK.Half.Life NA 2.649 hours 1compartment NA NA Rat Human -DTXSID7045865 Css NA 1.229 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045865 Css NA 10.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045865 Css NA 0.6766 mg/L PBTK NA 50% Rat Human -DTXSID7045865 Css NA 5.505 mg/L PBTK NA 95% Rat Human -DTXSID7045867 Clint NA 7.615 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045867 Fup NA 0.0335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045867 Vd NA 2.896 L/kg 1compartment NA NA Human Human -DTXSID7045867 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID7045867 TK.Half.Life NA 107.5 hours 1compartment NA NA Human Human -DTXSID7045867 Css NA 4.945 mg/L 3compartmentss NA 50% Human Human -DTXSID7045867 Css NA 28.01 mg/L 3compartmentss NA 95% Human Human -DTXSID7045867 Css NA 3.381 mg/L PBTK NA 50% Human Human -DTXSID7045867 Css NA 18.72 mg/L PBTK NA 95% Human Human -DTXSID7045867 Clint NA 7.615 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045867 Fup NA 0.0335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045867 Vd NA 2.17 L/kg 1compartment NA NA Rat Human -DTXSID7045867 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID7045867 TK.Half.Life NA 18.56 hours 1compartment NA NA Rat Human -DTXSID7045867 Css NA 2.727 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045867 Css NA 12.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045867 Css NA 1.772 mg/L PBTK NA 50% Rat Human -DTXSID7045867 Css NA 8.144 mg/L PBTK NA 95% Rat Human -DTXSID7045940 Clint NA 0.6352 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045940 Fup NA 0.3884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045940 Vd NA 0.9524 L/kg 1compartment NA NA Human Human +DTXSID7045865 TK.Half.Life NA 1.864 hours 1compartment NA NA Rat Human +DTXSID7045865 Css NA 0.09622 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045865 Css NA 0.565 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045865 Css NA 0.05724 mg/L PBTK NA 50% Rat Human +DTXSID7045865 Css NA 0.3328 mg/L PBTK NA 95% Rat Human +DTXSID7045867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045867 Fup 0.0144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045867 Vd NA 2.343 L/kg 1compartment NA NA Human Human +DTXSID7045867 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7045867 TK.Half.Life NA 32.53 hours 1compartment NA NA Human Human +DTXSID7045867 Css NA 1.993 mg/L 3compartmentss NA 50% Human Human +DTXSID7045867 Css NA 15.51 mg/L 3compartmentss NA 95% Human Human +DTXSID7045867 Css NA 1.293 mg/L PBTK NA 50% Human Human +DTXSID7045867 Css NA 9.724 mg/L PBTK NA 95% Human Human +DTXSID7045867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045867 Fup 0.0144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045867 Vd NA 1.744 L/kg 1compartment NA NA Rat Human +DTXSID7045867 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7045867 TK.Half.Life NA 8.804 hours 1compartment NA NA Rat Human +DTXSID7045867 Css NA 0.2604 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045867 Css NA 1.658 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045867 Css NA 0.1666 mg/L PBTK NA 50% Rat Human +DTXSID7045867 Css NA 1.019 mg/L PBTK NA 95% Rat Human +DTXSID7045940 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045940 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045940 Vd NA 0.7788 L/kg 1compartment NA NA Human Human DTXSID7045940 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045940 TK.Half.Life NA 8.071 hours 1compartment NA NA Human Human -DTXSID7045940 Css NA 0.8709 mg/L 3compartmentss NA 50% Human Human -DTXSID7045940 Css NA 4.073 mg/L 3compartmentss NA 95% Human Human -DTXSID7045940 Css NA 0.6817 mg/L PBTK NA 50% Human Human -DTXSID7045940 Css NA 2.666 mg/L PBTK NA 95% Human Human -DTXSID7045940 Clint NA 0.6352 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045940 Fup NA 0.3884 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045940 Vd NA 0.8982 L/kg 1compartment NA NA Rat Human +DTXSID7045940 TK.Half.Life NA 0.9192 hours 1compartment NA NA Human Human +DTXSID7045940 Css NA 0.05422 mg/L 3compartmentss NA 50% Human Human +DTXSID7045940 Css NA 0.4382 mg/L 3compartmentss NA 95% Human Human +DTXSID7045940 Css NA 0.04044 mg/L PBTK NA 50% Human Human +DTXSID7045940 Css NA 0.302 mg/L PBTK NA 95% Human Human +DTXSID7045940 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045940 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045940 Vd NA 0.7533 L/kg 1compartment NA NA Rat Human DTXSID7045940 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045940 TK.Half.Life NA 3.411 hours 1compartment NA NA Rat Human -DTXSID7045940 Css NA 0.3242 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045940 Css NA 1.326 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045940 Css NA 0.244 mg/L PBTK NA 50% Rat Human -DTXSID7045940 Css NA 0.8076 mg/L PBTK NA 95% Rat Human -DTXSID7045942 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045942 Fup NA 0.5327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045942 Vd NA 3.137 L/kg 1compartment NA NA Human Human -DTXSID7045942 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID7045942 TK.Half.Life NA 93040 hours 1compartment NA NA Human Human -DTXSID7045942 Css NA 3351 mg/L 3compartmentss NA 50% Human Human -DTXSID7045942 Css NA 8667 mg/L 3compartmentss NA 95% Human Human -DTXSID7045942 Css NA 2330 mg/L PBTK NA 50% Human Human -DTXSID7045942 Css NA 5617 mg/L PBTK NA 95% Human Human -DTXSID7045942 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045942 Fup NA 0.5327 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045942 Vd NA 2.351 L/kg 1compartment NA NA Rat Human -DTXSID7045942 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID7045942 TK.Half.Life NA 5672 hours 1compartment NA NA Rat Human -DTXSID7045942 Css NA 906.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045942 Css NA 1970 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045942 Css NA 605.4 mg/L PBTK NA 50% Rat Human -DTXSID7045942 Css NA 1192 mg/L PBTK NA 95% Rat Human -DTXSID7045944 Clint NA 5.668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045944 Fup NA 0.5371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045944 Vd NA 3.275 L/kg 1compartment NA NA Human Human -DTXSID7045944 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045944 TK.Half.Life NA 4.878 hours 1compartment NA NA Human Human -DTXSID7045944 Css NA 0.08953 mg/L 3compartmentss NA 50% Human Human -DTXSID7045944 Css NA 0.8678 mg/L 3compartmentss NA 95% Human Human -DTXSID7045944 Css NA 0.1062 mg/L PBTK NA 50% Human Human -DTXSID7045944 Css NA 0.7086 mg/L PBTK NA 95% Human Human -DTXSID7045944 Clint NA 5.668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045944 Fup NA 0.5371 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045944 Vd NA 3.329 L/kg 1compartment NA NA Rat Human -DTXSID7045944 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045944 TK.Half.Life NA 2.81 hours 1compartment NA NA Rat Human -DTXSID7045944 Css NA 0.04239 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045944 Css NA 0.3832 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045944 Css NA 0.05051 mg/L PBTK NA 50% Rat Human -DTXSID7045944 Css NA 0.2807 mg/L PBTK NA 95% Rat Human +DTXSID7045940 TK.Half.Life NA 0.4636 hours 1compartment NA NA Rat Human +DTXSID7045940 Css NA 0.006816 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045940 Css NA 0.03994 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045940 Css NA 0.005062 mg/L PBTK NA 50% Rat Human +DTXSID7045940 Css NA 0.0272 mg/L PBTK NA 95% Rat Human +DTXSID7045944 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045944 Fup 0.541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045944 Vd NA 3.424 L/kg 1compartment NA NA Human Human +DTXSID7045944 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7045944 TK.Half.Life NA 41.83 hours 1compartment NA NA Human Human +DTXSID7045944 Css NA 0.8504 mg/L 3compartmentss NA 50% Human Human +DTXSID7045944 Css NA 6.934 mg/L 3compartmentss NA 95% Human Human +DTXSID7045944 Css NA 1.042 mg/L PBTK NA 50% Human Human +DTXSID7045944 Css NA 5.219 mg/L PBTK NA 95% Human Human +DTXSID7045944 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045944 Fup 0.541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045944 Vd NA 3.482 L/kg 1compartment NA NA Rat Human +DTXSID7045944 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7045944 TK.Half.Life NA 14.27 hours 1compartment NA NA Rat Human +DTXSID7045944 Css NA 0.05071 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045944 Css NA 0.3795 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045944 Css NA 0.06392 mg/L PBTK NA 50% Rat Human +DTXSID7045944 Css NA 0.2748 mg/L PBTK NA 95% Rat Human DTXSID7045946 Clint 3.271 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7045946 Fup 0.08 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID7045946 Vd NA 2.363 L/kg 1compartment NA NA Human Human -DTXSID7045946 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID7045946 TK.Half.Life NA 56.54 hours 1compartment NA NA Human Human -DTXSID7045946 Css NA 3.51 mg/L 3compartmentss NA 50% Human Human -DTXSID7045946 Css NA 17.72 mg/L 3compartmentss NA 95% Human Human -DTXSID7045946 Css NA 2.277 mg/L PBTK NA 50% Human Human -DTXSID7045946 Css NA 11.04 mg/L PBTK NA 95% Human Human +DTXSID7045946 Vd NA 2.03 L/kg 1compartment NA NA Human Human +DTXSID7045946 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7045946 TK.Half.Life NA 38.96 hours 1compartment NA NA Human Human +DTXSID7045946 Css NA 2.368 mg/L 3compartmentss NA 50% Human Human +DTXSID7045946 Css NA 11.68 mg/L 3compartmentss NA 95% Human Human +DTXSID7045946 Css NA 1.799 mg/L PBTK NA 50% Human Human +DTXSID7045946 Css NA 8.878 mg/L PBTK NA 95% Human Human DTXSID7045946 Clint 3.271 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID7045946 Fup 0.08 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human -DTXSID7045946 Vd NA 1.979 L/kg 1compartment NA NA Rat Human -DTXSID7045946 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID7045946 TK.Half.Life NA 11.44 hours 1compartment NA NA Rat Human -DTXSID7045946 Css NA 1.495 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045946 Css NA 4.848 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045946 Css NA 0.8856 mg/L PBTK NA 50% Rat Human -DTXSID7045946 Css NA 2.811 mg/L PBTK NA 95% Rat Human -DTXSID7045948 Clint NA 10.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045948 Fup NA 0.5364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045948 Vd NA 1.124 L/kg 1compartment NA NA Human Human +DTXSID7045946 Vd NA 1.778 L/kg 1compartment NA NA Rat Human +DTXSID7045946 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID7045946 TK.Half.Life NA 9.273 hours 1compartment NA NA Rat Human +DTXSID7045946 Css NA 0.1992 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045946 Css NA 0.6771 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045946 Css NA 0.1568 mg/L PBTK NA 50% Rat Human +DTXSID7045946 Css NA 0.5325 mg/L PBTK NA 95% Rat Human +DTXSID7045948 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045948 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045948 Vd NA 0.4628 L/kg 1compartment NA NA Human Human DTXSID7045948 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045948 TK.Half.Life NA 1.422 hours 1compartment NA NA Human Human -DTXSID7045948 Css NA 0.07824 mg/L 3compartmentss NA 50% Human Human -DTXSID7045948 Css NA 0.6695 mg/L 3compartmentss NA 95% Human Human -DTXSID7045948 Css NA 0.06465 mg/L PBTK NA 50% Human Human -DTXSID7045948 Css NA 0.4681 mg/L PBTK NA 95% Human Human -DTXSID7045948 Clint NA 10.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045948 Fup NA 0.5364 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045948 Vd NA 1.01 L/kg 1compartment NA NA Rat Human +DTXSID7045948 TK.Half.Life NA 0.7058 hours 1compartment NA NA Human Human +DTXSID7045948 Css NA 0.09112 mg/L 3compartmentss NA 50% Human Human +DTXSID7045948 Css NA 0.6928 mg/L 3compartmentss NA 95% Human Human +DTXSID7045948 Css NA 0.06696 mg/L PBTK NA 50% Human Human +DTXSID7045948 Css NA 0.4584 mg/L PBTK NA 95% Human Human +DTXSID7045948 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045948 Fup 0.496 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045948 Vd NA 0.4862 L/kg 1compartment NA NA Rat Human DTXSID7045948 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045948 TK.Half.Life NA 0.6633 hours 1compartment NA NA Rat Human -DTXSID7045948 Css NA 0.03933 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045948 Css NA 0.2919 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045948 Css NA 0.03166 mg/L PBTK NA 50% Rat Human -DTXSID7045948 Css NA 0.189 mg/L PBTK NA 95% Rat Human -DTXSID7045992 Clint NA 11.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045992 Fup NA 0.6767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045992 Vd NA 3.768 L/kg 1compartment NA NA Human Human -DTXSID7045992 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045992 TK.Half.Life NA 2.957 hours 1compartment NA NA Human Human -DTXSID7045992 Css NA 0.03589 mg/L 3compartmentss NA 50% Human Human -DTXSID7045992 Css NA 0.4245 mg/L 3compartmentss NA 95% Human Human -DTXSID7045992 Css NA 0.04639 mg/L PBTK NA 50% Human Human -DTXSID7045992 Css NA 0.3703 mg/L PBTK NA 95% Human Human -DTXSID7045992 Clint NA 11.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045992 Fup NA 0.6767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045992 Vd NA 3.825 L/kg 1compartment NA NA Rat Human -DTXSID7045992 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045992 TK.Half.Life NA 1.653 hours 1compartment NA NA Rat Human -DTXSID7045992 Css NA 0.017 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045992 Css NA 0.196 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045992 Css NA 0.02267 mg/L PBTK NA 50% Rat Human -DTXSID7045992 Css NA 0.1511 mg/L PBTK NA 95% Rat Human -DTXSID7045998 Clint NA 17.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045998 Fup NA 0.0342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7045998 Vd NA 1.326 L/kg 1compartment NA NA Human Human +DTXSID7045948 TK.Half.Life NA 0.4002 hours 1compartment NA NA Rat Human +DTXSID7045948 Css NA 0.004063 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045948 Css NA 0.03751 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045948 Css NA 0.002968 mg/L PBTK NA 50% Rat Human +DTXSID7045948 Css NA 0.02388 mg/L PBTK NA 95% Rat Human +DTXSID7045992 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045992 Fup 0.576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045992 Vd NA 3.354 L/kg 1compartment NA NA Human Human +DTXSID7045992 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7045992 TK.Half.Life NA 37.75 hours 1compartment NA NA Human Human +DTXSID7045992 Css NA 0.7895 mg/L 3compartmentss NA 50% Human Human +DTXSID7045992 Css NA 7.287 mg/L 3compartmentss NA 95% Human Human +DTXSID7045992 Css NA 0.9856 mg/L PBTK NA 50% Human Human +DTXSID7045992 Css NA 5.336 mg/L PBTK NA 95% Human Human +DTXSID7045992 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045992 Fup 0.576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045992 Vd NA 3.397 L/kg 1compartment NA NA Rat Human +DTXSID7045992 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7045992 TK.Half.Life NA 13.01 hours 1compartment NA NA Rat Human +DTXSID7045992 Css NA 0.0466 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045992 Css NA 0.4221 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045992 Css NA 0.06017 mg/L PBTK NA 50% Rat Human +DTXSID7045992 Css NA 0.2983 mg/L PBTK NA 95% Rat Human +DTXSID7045998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045998 Fup 0.0922 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7045998 Vd NA 2.111 L/kg 1compartment NA NA Human Human DTXSID7045998 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7045998 TK.Half.Life NA 9.485 hours 1compartment NA NA Human Human -DTXSID7045998 Css NA 1.141 mg/L 3compartmentss NA 50% Human Human -DTXSID7045998 Css NA 8.053 mg/L 3compartmentss NA 95% Human Human -DTXSID7045998 Css NA 0.7146 mg/L PBTK NA 50% Human Human -DTXSID7045998 Css NA 4.893 mg/L PBTK NA 95% Human Human -DTXSID7045998 Clint NA 17.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045998 Fup NA 0.0342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7045998 Vd NA 0.9916 L/kg 1compartment NA NA Rat Human +DTXSID7045998 TK.Half.Life NA 7.775 hours 1compartment NA NA Human Human +DTXSID7045998 Css NA 0.3619 mg/L 3compartmentss NA 50% Human Human +DTXSID7045998 Css NA 2.715 mg/L 3compartmentss NA 95% Human Human +DTXSID7045998 Css NA 0.2436 mg/L PBTK NA 50% Human Human +DTXSID7045998 Css NA 1.748 mg/L PBTK NA 95% Human Human +DTXSID7045998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045998 Fup 0.0922 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7045998 Vd NA 1.595 L/kg 1compartment NA NA Rat Human DTXSID7045998 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7045998 TK.Half.Life NA 3.838 hours 1compartment NA NA Rat Human -DTXSID7045998 Css NA 0.6367 mg/L 3compartmentss NA 50% Rat Human -DTXSID7045998 Css NA 3.523 mg/L 3compartmentss NA 95% Rat Human -DTXSID7045998 Css NA 0.3727 mg/L PBTK NA 50% Rat Human -DTXSID7045998 Css NA 1.997 mg/L PBTK NA 95% Rat Human -DTXSID7046041 Clint NA 10.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046041 Fup NA 0.3144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046041 Vd NA 1.502 L/kg 1compartment NA NA Human Human +DTXSID7045998 TK.Half.Life NA 2.465 hours 1compartment NA NA Rat Human +DTXSID7045998 Css NA 0.01766 mg/L 3compartmentss NA 50% Rat Human +DTXSID7045998 Css NA 0.1385 mg/L 3compartmentss NA 95% Rat Human +DTXSID7045998 Css NA 0.01167 mg/L PBTK NA 50% Rat Human +DTXSID7045998 Css NA 0.08736 mg/L PBTK NA 95% Rat Human +DTXSID7046041 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046041 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046041 Vd NA 1.067 L/kg 1compartment NA NA Human Human DTXSID7046041 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046041 TK.Half.Life NA 3.045 hours 1compartment NA NA Human Human -DTXSID7046041 Css NA 0.1606 mg/L 3compartmentss NA 50% Human Human -DTXSID7046041 Css NA 0.9966 mg/L 3compartmentss NA 95% Human Human -DTXSID7046041 Css NA 0.1223 mg/L PBTK NA 50% Human Human -DTXSID7046041 Css NA 0.7069 mg/L PBTK NA 95% Human Human -DTXSID7046041 Clint NA 10.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046041 Fup NA 0.3144 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046041 Vd NA 1.219 L/kg 1compartment NA NA Rat Human +DTXSID7046041 TK.Half.Life NA 2.053 hours 1compartment NA NA Human Human +DTXSID7046041 Css NA 0.154 mg/L 3compartmentss NA 50% Human Human +DTXSID7046041 Css NA 1.147 mg/L 3compartmentss NA 95% Human Human +DTXSID7046041 Css NA 0.1048 mg/L PBTK NA 50% Human Human +DTXSID7046041 Css NA 0.7357 mg/L PBTK NA 95% Human Human +DTXSID7046041 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046041 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046041 Vd NA 0.8596 L/kg 1compartment NA NA Rat Human DTXSID7046041 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046041 TK.Half.Life NA 1.24 hours 1compartment NA NA Rat Human -DTXSID7046041 Css NA 0.08322 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046041 Css NA 0.4154 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046041 Css NA 0.06156 mg/L PBTK NA 50% Rat Human -DTXSID7046041 Css NA 0.2704 mg/L PBTK NA 95% Rat Human -DTXSID7046045 Clint NA 8.178 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046045 Fup NA 0.3195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046045 Vd NA 0.4131 L/kg 1compartment NA NA Human Human +DTXSID7046041 TK.Half.Life NA 0.8871 hours 1compartment NA NA Rat Human +DTXSID7046041 Css NA 0.01957 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046041 Css NA 0.1162 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046041 Css NA 0.01311 mg/L PBTK NA 50% Rat Human +DTXSID7046041 Css NA 0.07263 mg/L PBTK NA 95% Rat Human +DTXSID7046045 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046045 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046045 Vd NA 0.5066 L/kg 1compartment NA NA Human Human DTXSID7046045 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046045 TK.Half.Life NA 0.8545 hours 1compartment NA NA Human Human -DTXSID7046045 Css NA 0.1731 mg/L 3compartmentss NA 50% Human Human -DTXSID7046045 Css NA 1.116 mg/L 3compartmentss NA 95% Human Human -DTXSID7046045 Css NA 0.1212 mg/L PBTK NA 50% Human Human -DTXSID7046045 Css NA 0.7154 mg/L PBTK NA 95% Human Human -DTXSID7046045 Clint NA 8.178 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046045 Fup NA 0.3195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046045 Vd NA 0.4144 L/kg 1compartment NA NA Rat Human +DTXSID7046045 TK.Half.Life NA 6.931 hours 1compartment NA NA Human Human +DTXSID7046045 Css NA 1.483 mg/L 3compartmentss NA 50% Human Human +DTXSID7046045 Css NA 7.042 mg/L 3compartmentss NA 95% Human Human +DTXSID7046045 Css NA 1.117 mg/L PBTK NA 50% Human Human +DTXSID7046045 Css NA 4.539 mg/L PBTK NA 95% Human Human +DTXSID7046045 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046045 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046045 Vd NA 0.5094 L/kg 1compartment NA NA Rat Human DTXSID7046045 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046045 TK.Half.Life NA 0.4834 hours 1compartment NA NA Rat Human -DTXSID7046045 Css NA 0.09066 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046045 Css NA 0.4378 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046045 Css NA 0.06025 mg/L PBTK NA 50% Rat Human -DTXSID7046045 Css NA 0.2653 mg/L PBTK NA 95% Rat Human -DTXSID7046047 Clint NA 2.989 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046047 Fup NA 0.2099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046047 Vd NA 0.6498 L/kg 1compartment NA NA Human Human +DTXSID7046045 TK.Half.Life NA 2.375 hours 1compartment NA NA Rat Human +DTXSID7046045 Css NA 0.09438 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046045 Css NA 0.3914 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046045 Css NA 0.07037 mg/L PBTK NA 50% Rat Human +DTXSID7046045 Css NA 0.2403 mg/L PBTK NA 95% Rat Human +DTXSID7046047 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046047 Fup 0.274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046047 Vd NA 0.7529 L/kg 1compartment NA NA Human Human DTXSID7046047 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046047 TK.Half.Life NA 3.753 hours 1compartment NA NA Human Human -DTXSID7046047 Css NA 0.6474 mg/L 3compartmentss NA 50% Human Human -DTXSID7046047 Css NA 3.284 mg/L 3compartmentss NA 95% Human Human -DTXSID7046047 Css NA 0.445 mg/L PBTK NA 50% Human Human -DTXSID7046047 Css NA 2.089 mg/L PBTK NA 95% Human Human -DTXSID7046047 Clint NA 2.989 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046047 Fup NA 0.2099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046047 Vd NA 0.5821 L/kg 1compartment NA NA Rat Human +DTXSID7046047 TK.Half.Life NA 1.034 hours 1compartment NA NA Human Human +DTXSID7046047 Css NA 0.07494 mg/L 3compartmentss NA 50% Human Human +DTXSID7046047 Css NA 0.5298 mg/L 3compartmentss NA 95% Human Human +DTXSID7046047 Css NA 0.05346 mg/L PBTK NA 50% Human Human +DTXSID7046047 Css NA 0.3545 mg/L PBTK NA 95% Human Human +DTXSID7046047 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046047 Fup 0.274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046047 Vd NA 0.6753 L/kg 1compartment NA NA Rat Human DTXSID7046047 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046047 TK.Half.Life NA 1.88 hours 1compartment NA NA Rat Human -DTXSID7046047 Css NA 0.3125 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046047 Css NA 1.142 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046047 Css NA 0.2051 mg/L PBTK NA 50% Rat Human -DTXSID7046047 Css NA 0.6794 mg/L PBTK NA 95% Rat Human -DTXSID7046091 Clint NA 54.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046091 Fup NA 0.0237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046091 Vd NA 1.496 L/kg 1compartment NA NA Human Human -DTXSID7046091 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046091 TK.Half.Life NA 5.71 hours 1compartment NA NA Human Human -DTXSID7046091 Css NA 0.5119 mg/L 3compartmentss NA 50% Human Human -DTXSID7046091 Css NA 4.589 mg/L 3compartmentss NA 95% Human Human -DTXSID7046091 Css NA 0.3196 mg/L PBTK NA 50% Human Human -DTXSID7046091 Css NA 2.793 mg/L PBTK NA 95% Human Human -DTXSID7046091 Clint NA 54.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046091 Fup NA 0.0237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046091 Vd NA 1.113 L/kg 1compartment NA NA Rat Human +DTXSID7046047 TK.Half.Life NA 0.4919 hours 1compartment NA NA Rat Human +DTXSID7046047 Css NA 0.00931 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046047 Css NA 0.05466 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046047 Css NA 0.006639 mg/L PBTK NA 50% Rat Human +DTXSID7046047 Css NA 0.03567 mg/L PBTK NA 95% Rat Human +DTXSID7046091 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046091 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046091 Vd NA 2.971 L/kg 1compartment NA NA Human Human +DTXSID7046091 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7046091 TK.Half.Life NA 18.93 hours 1compartment NA NA Human Human +DTXSID7046091 Css NA 0.684 mg/L 3compartmentss NA 50% Human Human +DTXSID7046091 Css NA 4.062 mg/L 3compartmentss NA 95% Human Human +DTXSID7046091 Css NA 0.4809 mg/L PBTK NA 50% Human Human +DTXSID7046091 Css NA 2.831 mg/L PBTK NA 95% Human Human +DTXSID7046091 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046091 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046091 Vd NA 2.238 L/kg 1compartment NA NA Rat Human DTXSID7046091 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046091 TK.Half.Life NA 2.176 hours 1compartment NA NA Rat Human -DTXSID7046091 Css NA 0.2925 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046091 Css NA 2.228 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046091 Css NA 0.1714 mg/L PBTK NA 50% Rat Human -DTXSID7046091 Css NA 1.259 mg/L PBTK NA 95% Rat Human -DTXSID7046093 Clint NA 1.377 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046093 Fup NA 0.1763 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046093 Vd NA 0.4055 L/kg 1compartment NA NA Human Human -DTXSID7046093 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046093 TK.Half.Life NA 4.665 hours 1compartment NA NA Human Human -DTXSID7046093 Css NA 1.386 mg/L 3compartmentss NA 50% Human Human -DTXSID7046093 Css NA 6.079 mg/L 3compartmentss NA 95% Human Human -DTXSID7046093 Css NA 0.9284 mg/L PBTK NA 50% Human Human -DTXSID7046093 Css NA 3.758 mg/L PBTK NA 95% Human Human -DTXSID7046093 Clint NA 1.377 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046093 Fup NA 0.1763 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046093 Vd NA 0.4063 L/kg 1compartment NA NA Rat Human +DTXSID7046091 TK.Half.Life NA 3.454 hours 1compartment NA NA Rat Human +DTXSID7046091 Css NA 0.08559 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046091 Css NA 0.4297 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046091 Css NA 0.06004 mg/L PBTK NA 50% Rat Human +DTXSID7046091 Css NA 0.2988 mg/L PBTK NA 95% Rat Human +DTXSID7046093 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046093 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046093 Vd NA 0.5091 L/kg 1compartment NA NA Human Human +DTXSID7046093 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7046093 TK.Half.Life NA 11.32 hours 1compartment NA NA Human Human +DTXSID7046093 Css NA 1.356 mg/L 3compartmentss NA 50% Human Human +DTXSID7046093 Css NA 5.883 mg/L 3compartmentss NA 95% Human Human +DTXSID7046093 Css NA 0.9785 mg/L PBTK NA 50% Human Human +DTXSID7046093 Css NA 3.715 mg/L PBTK NA 95% Human Human +DTXSID7046093 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046093 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046093 Vd NA 0.5144 L/kg 1compartment NA NA Rat Human DTXSID7046093 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046093 TK.Half.Life NA 2.438 hours 1compartment NA NA Rat Human -DTXSID7046093 Css NA 0.5981 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046093 Css NA 2.017 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046093 Css NA 0.3787 mg/L PBTK NA 50% Rat Human -DTXSID7046093 Css NA 1.164 mg/L PBTK NA 95% Rat Human -DTXSID7046095 Clint NA 911.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046095 Fup NA 0.1778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046095 Vd NA 0.271 L/kg 1compartment NA NA Human Human +DTXSID7046093 TK.Half.Life NA 3.898 hours 1compartment NA NA Rat Human +DTXSID7046093 Css NA 0.007282 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046093 Css NA 0.03118 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046093 Css NA 0.004997 mg/L PBTK NA 50% Rat Human +DTXSID7046093 Css NA 0.01946 mg/L PBTK NA 95% Rat Human +DTXSID7046095 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046095 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046095 Vd NA 0.3582 L/kg 1compartment NA NA Human Human DTXSID7046095 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046095 TK.Half.Life NA 0.2468 hours 1compartment NA NA Human Human -DTXSID7046095 Css NA 0.003334 mg/L 3compartmentss NA 50% Human Human -DTXSID7046095 Css NA 0.02489 mg/L 3compartmentss NA 95% Human Human -DTXSID7046095 Css NA 0.002106 mg/L PBTK NA 50% Human Human -DTXSID7046095 Css NA 0.01526 mg/L PBTK NA 95% Human Human -DTXSID7046095 Clint NA 911.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046095 Fup NA 0.1778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046095 Vd NA 0.2735 L/kg 1compartment NA NA Rat Human +DTXSID7046095 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human +DTXSID7046095 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human +DTXSID7046095 Css NA 4.74 mg/L 3compartmentss NA 95% Human Human +DTXSID7046095 Css NA 0.7152 mg/L PBTK NA 50% Human Human +DTXSID7046095 Css NA 2.949 mg/L PBTK NA 95% Human Human +DTXSID7046095 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046095 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046095 Vd NA 0.3669 L/kg 1compartment NA NA Rat Human DTXSID7046095 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046095 TK.Half.Life NA 0.1101 hours 1compartment NA NA Rat Human -DTXSID7046095 Css NA 0.001904 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046095 Css NA 0.01194 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046095 Css NA 0.001129 mg/L PBTK NA 50% Rat Human -DTXSID7046095 Css NA 0.006825 mg/L PBTK NA 95% Rat Human -DTXSID7046097 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046097 Fup NA 0.8373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046097 Vd NA 0.4982 L/kg 1compartment NA NA Human Human +DTXSID7046095 TK.Half.Life NA 2.021 hours 1compartment NA NA Rat Human +DTXSID7046095 Css NA 0.005684 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046095 Css NA 0.02539 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046095 Css NA 0.003729 mg/L PBTK NA 50% Rat Human +DTXSID7046095 Css NA 0.01497 mg/L PBTK NA 95% Rat Human +DTXSID7046097 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046097 Fup 0.668 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046097 Vd NA 0.3843 L/kg 1compartment NA NA Human Human DTXSID7046097 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046097 TK.Half.Life NA 3.849 hours 1compartment NA NA Human Human -DTXSID7046097 Css NA 1.067 mg/L 3compartmentss NA 50% Human Human -DTXSID7046097 Css NA 5.704 mg/L 3compartmentss NA 95% Human Human -DTXSID7046097 Css NA 0.7937 mg/L PBTK NA 50% Human Human -DTXSID7046097 Css NA 3.594 mg/L PBTK NA 95% Human Human -DTXSID7046097 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046097 Fup NA 0.8373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046097 Vd NA 0.5243 L/kg 1compartment NA NA Rat Human +DTXSID7046097 TK.Half.Life NA 3.723 hours 1compartment NA NA Human Human +DTXSID7046097 Css NA 1.243 mg/L 3compartmentss NA 50% Human Human +DTXSID7046097 Css NA 7.594 mg/L 3compartmentss NA 95% Human Human +DTXSID7046097 Css NA 0.8774 mg/L PBTK NA 50% Human Human +DTXSID7046097 Css NA 4.523 mg/L PBTK NA 95% Human Human +DTXSID7046097 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046097 Fup 0.668 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046097 Vd NA 0.4075 L/kg 1compartment NA NA Rat Human DTXSID7046097 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046097 TK.Half.Life NA 1.381 hours 1compartment NA NA Rat Human -DTXSID7046097 Css NA 0.2776 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046097 Css NA 1.494 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046097 Css NA 0.198 mg/L PBTK NA 50% Rat Human -DTXSID7046097 Css NA 0.8658 mg/L PBTK NA 95% Rat Human -DTXSID7046099 Clint NA 90.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046099 Fup NA 0.2283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046099 Vd NA 2.614 L/kg 1compartment NA NA Human Human +DTXSID7046097 TK.Half.Life NA 1.345 hours 1compartment NA NA Rat Human +DTXSID7046097 Css NA 0.07661 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046097 Css NA 0.4236 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046097 Css NA 0.05346 mg/L PBTK NA 50% Rat Human +DTXSID7046097 Css NA 0.2496 mg/L PBTK NA 95% Rat Human +DTXSID7046099 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046099 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046099 Vd NA 2.178 L/kg 1compartment NA NA Human Human DTXSID7046099 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046099 TK.Half.Life NA 1.955 hours 1compartment NA NA Human Human -DTXSID7046099 Css NA 0.01699 mg/L 3compartmentss NA 50% Human Human -DTXSID7046099 Css NA 0.1393 mg/L 3compartmentss NA 95% Human Human -DTXSID7046099 Css NA 0.01608 mg/L PBTK NA 50% Human Human -DTXSID7046099 Css NA 0.1117 mg/L PBTK NA 95% Human Human -DTXSID7046099 Clint NA 90.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046099 Fup NA 0.2283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046099 Vd NA 2.557 L/kg 1compartment NA NA Rat Human +DTXSID7046099 TK.Half.Life NA 3.447 hours 1compartment NA NA Human Human +DTXSID7046099 Css NA 0.1011 mg/L 3compartmentss NA 50% Human Human +DTXSID7046099 Css NA 0.866 mg/L 3compartmentss NA 95% Human Human +DTXSID7046099 Css NA 0.1 mg/L PBTK NA 50% Human Human +DTXSID7046099 Css NA 0.6661 mg/L PBTK NA 95% Human Human +DTXSID7046099 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046099 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046099 Vd NA 2.201 L/kg 1compartment NA NA Rat Human DTXSID7046099 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046099 TK.Half.Life NA 0.9251 hours 1compartment NA NA Rat Human -DTXSID7046099 Css NA 0.009185 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046099 Css NA 0.0608 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046099 Css NA 0.008536 mg/L PBTK NA 50% Rat Human -DTXSID7046099 Css NA 0.04767 mg/L PBTK NA 95% Rat Human -DTXSID7046120 Clint NA 43.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046120 Fup NA 0.1023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046120 Vd NA 3.091 L/kg 1compartment NA NA Human Human -DTXSID7046120 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046120 TK.Half.Life NA 14.24 hours 1compartment NA NA Human Human -DTXSID7046120 Css NA 0.4822 mg/L 3compartmentss NA 50% Human Human -DTXSID7046120 Css NA 3.137 mg/L 3compartmentss NA 95% Human Human -DTXSID7046120 Css NA 0.3442 mg/L PBTK NA 50% Human Human -DTXSID7046120 Css NA 2.143 mg/L PBTK NA 95% Human Human -DTXSID7046120 Clint NA 43.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046120 Fup NA 0.1023 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046120 Vd NA 2.371 L/kg 1compartment NA NA Rat Human -DTXSID7046120 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046120 TK.Half.Life NA 2.79 hours 1compartment NA NA Rat Human -DTXSID7046120 Css NA 0.2672 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046120 Css NA 1.441 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046120 Css NA 0.1832 mg/L PBTK NA 50% Rat Human -DTXSID7046120 Css NA 0.9499 mg/L PBTK NA 95% Rat Human -DTXSID7046122 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046122 Fup NA 0.0304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046122 Vd NA 0.3964 L/kg 1compartment NA NA Human Human -DTXSID7046122 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID7046122 TK.Half.Life NA 85.63 hours 1compartment NA NA Human Human -DTXSID7046122 Css NA 35.66 mg/L 3compartmentss NA 50% Human Human -DTXSID7046122 Css NA 219.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7046122 Css NA 21.8 mg/L PBTK NA 50% Human Human -DTXSID7046122 Css NA 126.4 mg/L PBTK NA 95% Human Human -DTXSID7046122 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046122 Fup NA 0.0304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046122 Vd NA 0.343 L/kg 1compartment NA NA Rat Human -DTXSID7046122 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID7046122 TK.Half.Life NA 24.97 hours 1compartment NA NA Rat Human -DTXSID7046122 Css NA 10.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046122 Css NA 52.69 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046122 Css NA 5.827 mg/L PBTK NA 50% Rat Human -DTXSID7046122 Css NA 28.79 mg/L PBTK NA 95% Rat Human +DTXSID7046099 TK.Half.Life NA 1.963 hours 1compartment NA NA Rat Human +DTXSID7046099 Css NA 0.0115 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046099 Css NA 0.08075 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046099 Css NA 0.01166 mg/L PBTK NA 50% Rat Human +DTXSID7046099 Css NA 0.05893 mg/L PBTK NA 95% Rat Human +DTXSID7046120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046120 Fup 0.0619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046120 Vd NA 2.803 L/kg 1compartment NA NA Human Human +DTXSID7046120 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7046120 TK.Half.Life NA 19.08 hours 1compartment NA NA Human Human +DTXSID7046120 Css NA 0.8082 mg/L 3compartmentss NA 50% Human Human +DTXSID7046120 Css NA 5.449 mg/L 3compartmentss NA 95% Human Human +DTXSID7046120 Css NA 0.5658 mg/L PBTK NA 50% Human Human +DTXSID7046120 Css NA 3.684 mg/L PBTK NA 95% Human Human +DTXSID7046120 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046120 Fup 0.0619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046120 Vd NA 2.167 L/kg 1compartment NA NA Rat Human +DTXSID7046120 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7046120 TK.Half.Life NA 4.636 hours 1compartment NA NA Rat Human +DTXSID7046120 Css NA 0.1041 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046120 Css NA 0.5721 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046120 Css NA 0.07236 mg/L PBTK NA 50% Rat Human +DTXSID7046120 Css NA 0.3871 mg/L PBTK NA 95% Rat Human +DTXSID7046122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046122 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046122 Vd NA 0.4114 L/kg 1compartment NA NA Human Human +DTXSID7046122 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7046122 TK.Half.Life NA 1.948 hours 1compartment NA NA Human Human +DTXSID7046122 Css NA 0.5774 mg/L 3compartmentss NA 50% Human Human +DTXSID7046122 Css NA 5.589 mg/L 3compartmentss NA 95% Human Human +DTXSID7046122 Css NA 0.358 mg/L PBTK NA 50% Human Human +DTXSID7046122 Css NA 3.342 mg/L PBTK NA 95% Human Human +DTXSID7046122 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046122 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046122 Vd NA 0.3628 L/kg 1compartment NA NA Rat Human +DTXSID7046122 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7046122 TK.Half.Life NA 1.079 hours 1compartment NA NA Rat Human +DTXSID7046122 Css NA 0.02841 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046122 Css NA 0.2882 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046122 Css NA 0.01706 mg/L PBTK NA 50% Rat Human +DTXSID7046122 Css NA 0.1652 mg/L PBTK NA 95% Rat Human DTXSID7046126 Clint 1.4 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.106.011569 NA Human Human -DTXSID7046126 Fup NA 0.3442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046126 Vd NA 1.146 L/kg 1compartment NA NA Human Human +DTXSID7046126 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046126 Vd NA 1.116 L/kg 1compartment NA NA Human Human DTXSID7046126 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046126 TK.Half.Life NA 7.452 hours 1compartment NA NA Human Human -DTXSID7046126 Css NA 0.6714 mg/L 3compartmentss NA 50% Human Human -DTXSID7046126 Css NA 3.221 mg/L 3compartmentss NA 95% Human Human -DTXSID7046126 Css NA 0.5184 mg/L PBTK NA 50% Human Human -DTXSID7046126 Css NA 2.129 mg/L PBTK NA 95% Human Human +DTXSID7046126 TK.Half.Life NA 7.569 hours 1compartment NA NA Human Human +DTXSID7046126 Css NA 0.6929 mg/L 3compartmentss NA 50% Human Human +DTXSID7046126 Css NA 3.381 mg/L 3compartmentss NA 95% Human Human +DTXSID7046126 Css NA 0.5258 mg/L PBTK NA 50% Human Human +DTXSID7046126 Css NA 2.202 mg/L PBTK NA 95% Human Human DTXSID7046126 Clint 1.4 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.106.011569 NA Rat Human -DTXSID7046126 Fup NA 0.3442 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046126 Vd NA 0.9751 L/kg 1compartment NA NA Rat Human +DTXSID7046126 Fup 0.328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046126 Vd NA 0.9491 L/kg 1compartment NA NA Rat Human DTXSID7046126 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046126 TK.Half.Life NA 3.037 hours 1compartment NA NA Rat Human -DTXSID7046126 Css NA 0.285 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046126 Css NA 1.087 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046126 Css NA 0.212 mg/L PBTK NA 50% Rat Human -DTXSID7046126 Css NA 0.6713 mg/L PBTK NA 95% Rat Human -DTXSID7046128 Clint NA 6.998 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046128 Fup NA 0.2307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046128 Vd NA 1.283 L/kg 1compartment NA NA Human Human +DTXSID7046126 TK.Half.Life NA 3.096 hours 1compartment NA NA Rat Human +DTXSID7046126 Css NA 0.06793 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046126 Css NA 0.2602 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046126 Css NA 0.05173 mg/L PBTK NA 50% Rat Human +DTXSID7046126 Css NA 0.1648 mg/L PBTK NA 95% Rat Human +DTXSID7046128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046128 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046128 Vd NA 1.829 L/kg 1compartment NA NA Human Human DTXSID7046128 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046128 TK.Half.Life NA 3.362 hours 1compartment NA NA Human Human -DTXSID7046128 Css NA 0.2186 mg/L 3compartmentss NA 50% Human Human -DTXSID7046128 Css NA 1.398 mg/L 3compartmentss NA 95% Human Human -DTXSID7046128 Css NA 0.1782 mg/L PBTK NA 50% Human Human -DTXSID7046128 Css NA 1.017 mg/L PBTK NA 95% Human Human -DTXSID7046128 Clint NA 6.998 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046128 Fup NA 0.2307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046128 Vd NA 1.25 L/kg 1compartment NA NA Rat Human +DTXSID7046128 TK.Half.Life NA 3.719 hours 1compartment NA NA Human Human +DTXSID7046128 Css NA 0.07718 mg/L 3compartmentss NA 50% Human Human +DTXSID7046128 Css NA 0.6253 mg/L 3compartmentss NA 95% Human Human +DTXSID7046128 Css NA 0.05504 mg/L PBTK NA 50% Human Human +DTXSID7046128 Css NA 0.4187 mg/L PBTK NA 95% Human Human +DTXSID7046128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046128 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046128 Vd NA 1.415 L/kg 1compartment NA NA Rat Human DTXSID7046128 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046128 TK.Half.Life NA 1.937 hours 1compartment NA NA Rat Human -DTXSID7046128 Css NA 0.1104 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046128 Css NA 0.5529 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046128 Css NA 0.08848 mg/L PBTK NA 50% Rat Human -DTXSID7046128 Css NA 0.3724 mg/L PBTK NA 95% Rat Human -DTXSID7046170 Clint NA 49.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046170 Fup NA 0.0113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046170 Vd NA 5.653 L/kg 1compartment NA NA Human Human -DTXSID7046170 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7046170 TK.Half.Life NA 36.66 hours 1compartment NA NA Human Human -DTXSID7046170 Css NA 0.7458 mg/L 3compartmentss NA 50% Human Human -DTXSID7046170 Css NA 7.208 mg/L 3compartmentss NA 95% Human Human -DTXSID7046170 Css NA 0.6306 mg/L PBTK NA 50% Human Human -DTXSID7046170 Css NA 5.141 mg/L PBTK NA 95% Human Human -DTXSID7046170 Clint NA 49.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046170 Fup NA 0.0113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046170 Vd NA 4.355 L/kg 1compartment NA NA Rat Human -DTXSID7046170 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7046170 TK.Half.Life NA 13.07 hours 1compartment NA NA Rat Human -DTXSID7046170 Css NA 0.4109 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046170 Css NA 3.445 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046170 Css NA 0.3365 mg/L PBTK NA 50% Rat Human -DTXSID7046170 Css NA 2.335 mg/L PBTK NA 95% Rat Human +DTXSID7046128 TK.Half.Life NA 1.333 hours 1compartment NA NA Rat Human +DTXSID7046128 Css NA 0.0007594 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046128 Css NA 0.00566 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046128 Css NA 0.0005255 mg/L PBTK NA 50% Rat Human +DTXSID7046128 Css NA 0.003711 mg/L PBTK NA 95% Rat Human +DTXSID7046170 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046170 Fup 0.032 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046170 Vd NA 7.908 L/kg 1compartment NA NA Human Human +DTXSID7046170 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID7046170 TK.Half.Life NA 71.19 hours 1compartment NA NA Human Human +DTXSID7046170 Css NA 0.8333 mg/L 3compartmentss NA 50% Human Human +DTXSID7046170 Css NA 6.547 mg/L 3compartmentss NA 95% Human Human +DTXSID7046170 Css NA 0.855 mg/L PBTK NA 50% Human Human +DTXSID7046170 Css NA 5.732 mg/L PBTK NA 95% Human Human +DTXSID7046170 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046170 Fup 0.032 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046170 Vd NA 6.18 L/kg 1compartment NA NA Rat Human +DTXSID7046170 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID7046170 TK.Half.Life NA 18.67 hours 1compartment NA NA Rat Human +DTXSID7046170 Css NA 0.1014 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046170 Css NA 0.7072 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046170 Css NA 0.1061 mg/L PBTK NA 50% Rat Human +DTXSID7046170 Css NA 0.6209 mg/L PBTK NA 95% Rat Human DTXSID7046172 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7046172 Fup NA 0.4812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046172 Vd NA 0.5001 L/kg 1compartment NA NA Human Human +DTXSID7046172 Vd NA 0.5576 L/kg 1compartment NA NA Human Human DTXSID7046172 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046172 TK.Half.Life NA 6.723 hours 1compartment NA NA Human Human -DTXSID7046172 Css NA 1.526 mg/L 3compartmentss NA 50% Human Human -DTXSID7046172 Css NA 7.468 mg/L 3compartmentss NA 95% Human Human -DTXSID7046172 Css NA 1.134 mg/L PBTK NA 50% Human Human -DTXSID7046172 Css NA 4.682 mg/L PBTK NA 95% Human Human +DTXSID7046172 TK.Half.Life NA 7.506 hours 1compartment NA NA Human Human +DTXSID7046172 Css NA 1.274 mg/L 3compartmentss NA 50% Human Human +DTXSID7046172 Css NA 6.356 mg/L 3compartmentss NA 95% Human Human +DTXSID7046172 Css NA 0.961 mg/L PBTK NA 50% Human Human +DTXSID7046172 Css NA 4.045 mg/L PBTK NA 95% Human Human DTXSID7046172 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7046172 Fup NA 0.4812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046172 Vd NA 0.5245 L/kg 1compartment NA NA Rat Human +DTXSID7046172 Vd NA 0.5728 L/kg 1compartment NA NA Rat Human DTXSID7046172 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046172 TK.Half.Life NA 2.403 hours 1compartment NA NA Rat Human -DTXSID7046172 Css NA 0.4186 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046172 Css NA 1.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046172 Css NA 0.2952 mg/L PBTK NA 50% Rat Human -DTXSID7046172 Css NA 1.055 mg/L PBTK NA 95% Rat Human -DTXSID7046174 Clint NA 42.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046174 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046174 Vd NA 1.298 L/kg 1compartment NA NA Human Human +DTXSID7046172 TK.Half.Life NA 2.626 hours 1compartment NA NA Rat Human +DTXSID7046172 Css NA 0.02375 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046172 Css NA 0.1701 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046172 Css NA 0.01728 mg/L PBTK NA 50% Rat Human +DTXSID7046172 Css NA 0.108 mg/L PBTK NA 95% Rat Human +DTXSID7046174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046174 Fup 0.043 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046174 Vd NA 0.8726 L/kg 1compartment NA NA Human Human DTXSID7046174 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046174 TK.Half.Life NA 2.992 hours 1compartment NA NA Human Human -DTXSID7046174 Css NA 0.2296 mg/L 3compartmentss NA 50% Human Human -DTXSID7046174 Css NA 1.682 mg/L 3compartmentss NA 95% Human Human -DTXSID7046174 Css NA 0.1476 mg/L PBTK NA 50% Human Human -DTXSID7046174 Css NA 1.033 mg/L PBTK NA 95% Human Human -DTXSID7046174 Clint NA 42.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046174 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046174 Vd NA 0.9875 L/kg 1compartment NA NA Rat Human +DTXSID7046174 TK.Half.Life NA 4.214 hours 1compartment NA NA Human Human +DTXSID7046174 Css NA 0.6823 mg/L 3compartmentss NA 50% Human Human +DTXSID7046174 Css NA 5.362 mg/L 3compartmentss NA 95% Human Human +DTXSID7046174 Css NA 0.4198 mg/L PBTK NA 50% Human Human +DTXSID7046174 Css NA 3.187 mg/L PBTK NA 95% Human Human +DTXSID7046174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046174 Fup 0.043 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046174 Vd NA 0.6685 L/kg 1compartment NA NA Rat Human DTXSID7046174 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046174 TK.Half.Life NA 1.187 hours 1compartment NA NA Rat Human -DTXSID7046174 Css NA 0.1302 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046174 Css NA 0.716 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046174 Css NA 0.07852 mg/L PBTK NA 50% Rat Human -DTXSID7046174 Css NA 0.4252 mg/L PBTK NA 95% Rat Human -DTXSID7046176 Clint NA 130.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046176 Fup NA 0.0335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046176 Vd NA 1.484 L/kg 1compartment NA NA Human Human -DTXSID7046176 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046176 TK.Half.Life NA 2.677 hours 1compartment NA NA Human Human -DTXSID7046176 Css NA 0.1651 mg/L 3compartmentss NA 50% Human Human -DTXSID7046176 Css NA 1.286 mg/L 3compartmentss NA 95% Human Human -DTXSID7046176 Css NA 0.1038 mg/L PBTK NA 50% Human Human -DTXSID7046176 Css NA 0.7796 mg/L PBTK NA 95% Human Human -DTXSID7046176 Clint NA 130.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046176 Fup NA 0.0335 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046176 Vd NA 1.108 L/kg 1compartment NA NA Rat Human +DTXSID7046174 TK.Half.Life NA 1.907 hours 1compartment NA NA Rat Human +DTXSID7046174 Css NA 0.09032 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046174 Css NA 0.5402 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046174 Css NA 0.05424 mg/L PBTK NA 50% Rat Human +DTXSID7046174 Css NA 0.3136 mg/L PBTK NA 95% Rat Human +DTXSID7046176 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046176 Fup 0.0869 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046176 Vd NA 1.829 L/kg 1compartment NA NA Human Human +DTXSID7046176 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7046176 TK.Half.Life NA 17.23 hours 1compartment NA NA Human Human +DTXSID7046176 Css NA 1.288 mg/L 3compartmentss NA 50% Human Human +DTXSID7046176 Css NA 7.945 mg/L 3compartmentss NA 95% Human Human +DTXSID7046176 Css NA 0.8606 mg/L PBTK NA 50% Human Human +DTXSID7046176 Css NA 4.97 mg/L PBTK NA 95% Human Human +DTXSID7046176 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046176 Fup 0.0869 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046176 Vd NA 1.384 L/kg 1compartment NA NA Rat Human DTXSID7046176 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046176 TK.Half.Life NA 0.9794 hours 1compartment NA NA Rat Human -DTXSID7046176 Css NA 0.09476 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046176 Css NA 0.598 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046176 Css NA 0.05595 mg/L PBTK NA 50% Rat Human -DTXSID7046176 Css NA 0.3469 mg/L PBTK NA 95% Rat Human -DTXSID7046178 Clint NA 75.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046178 Fup NA 0.0584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046178 Vd NA 0.8817 L/kg 1compartment NA NA Human Human +DTXSID7046176 TK.Half.Life NA 5.854 hours 1compartment NA NA Rat Human +DTXSID7046176 Css NA 0.1574 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046176 Css NA 0.7186 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046176 Css NA 0.1031 mg/L PBTK NA 50% Rat Human +DTXSID7046176 Css NA 0.4377 mg/L PBTK NA 95% Rat Human +DTXSID7046178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046178 Fup 0.0831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046178 Vd NA 1.121 L/kg 1compartment NA NA Human Human DTXSID7046178 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046178 TK.Half.Life NA 1.556 hours 1compartment NA NA Human Human -DTXSID7046178 Css NA 0.153 mg/L 3compartmentss NA 50% Human Human -DTXSID7046178 Css NA 1.261 mg/L 3compartmentss NA 95% Human Human -DTXSID7046178 Css NA 0.09515 mg/L PBTK NA 50% Human Human -DTXSID7046178 Css NA 0.753 mg/L PBTK NA 95% Human Human -DTXSID7046178 Clint NA 75.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046178 Fup NA 0.0584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046178 Vd NA 0.6794 L/kg 1compartment NA NA Rat Human +DTXSID7046178 TK.Half.Life NA 3.415 hours 1compartment NA NA Human Human +DTXSID7046178 Css NA 0.3567 mg/L 3compartmentss NA 50% Human Human +DTXSID7046178 Css NA 2.787 mg/L 3compartmentss NA 95% Human Human +DTXSID7046178 Css NA 0.2272 mg/L PBTK NA 50% Human Human +DTXSID7046178 Css NA 1.709 mg/L PBTK NA 95% Human Human +DTXSID7046178 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046178 Fup 0.0831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046178 Vd NA 0.8615 L/kg 1compartment NA NA Rat Human DTXSID7046178 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046178 TK.Half.Life NA 0.6406 hours 1compartment NA NA Rat Human -DTXSID7046178 Css NA 0.08895 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046178 Css NA 0.5785 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046178 Css NA 0.05189 mg/L PBTK NA 50% Rat Human -DTXSID7046178 Css NA 0.3318 mg/L PBTK NA 95% Rat Human -DTXSID7046201 Clint NA 11.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046201 Fup NA 0.551 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046201 Vd NA 1.094 L/kg 1compartment NA NA Human Human -DTXSID7046201 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046201 TK.Half.Life NA 1.292 hours 1compartment NA NA Human Human -DTXSID7046201 Css NA 0.06924 mg/L 3compartmentss NA 50% Human Human -DTXSID7046201 Css NA 0.6618 mg/L 3compartmentss NA 95% Human Human -DTXSID7046201 Css NA 0.05661 mg/L PBTK NA 50% Human Human -DTXSID7046201 Css NA 0.4503 mg/L PBTK NA 95% Human Human -DTXSID7046201 Clint NA 11.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046201 Fup NA 0.551 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046201 Vd NA 0.9813 L/kg 1compartment NA NA Rat Human +DTXSID7046178 TK.Half.Life NA 1.44 hours 1compartment NA NA Rat Human +DTXSID7046178 Css NA 0.0463 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046178 Css NA 0.2641 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046178 Css NA 0.02891 mg/L PBTK NA 50% Rat Human +DTXSID7046178 Css NA 0.1564 mg/L PBTK NA 95% Rat Human +DTXSID7046201 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046201 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046201 Vd NA 1.207 L/kg 1compartment NA NA Human Human +DTXSID7046201 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7046201 TK.Half.Life NA 21.97 hours 1compartment NA NA Human Human +DTXSID7046201 Css NA 1.851 mg/L 3compartmentss NA 50% Human Human +DTXSID7046201 Css NA 7.936 mg/L 3compartmentss NA 95% Human Human +DTXSID7046201 Css NA 1.461 mg/L PBTK NA 50% Human Human +DTXSID7046201 Css NA 5.265 mg/L PBTK NA 95% Human Human +DTXSID7046201 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046201 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046201 Vd NA 1.026 L/kg 1compartment NA NA Rat Human DTXSID7046201 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046201 TK.Half.Life NA 0.5965 hours 1compartment NA NA Rat Human -DTXSID7046201 Css NA 0.0352 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046201 Css NA 0.2824 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046201 Css NA 0.02778 mg/L PBTK NA 50% Rat Human -DTXSID7046201 Css NA 0.1774 mg/L PBTK NA 95% Rat Human -DTXSID7046205 Clint NA 11.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046205 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046205 Vd NA 0.9752 L/kg 1compartment NA NA Human Human +DTXSID7046201 TK.Half.Life NA 5.781 hours 1compartment NA NA Rat Human +DTXSID7046201 Css NA 0.1179 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046201 Css NA 0.4356 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046201 Css NA 0.09236 mg/L PBTK NA 50% Rat Human +DTXSID7046201 Css NA 0.2765 mg/L PBTK NA 95% Rat Human +DTXSID7046205 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046205 Fup 0.0558 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046205 Vd NA 3.506 L/kg 1compartment NA NA Human Human DTXSID7046205 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046205 TK.Half.Life NA 3.016 hours 1compartment NA NA Human Human -DTXSID7046205 Css NA 0.3823 mg/L 3compartmentss NA 50% Human Human -DTXSID7046205 Css NA 4.662 mg/L 3compartmentss NA 95% Human Human -DTXSID7046205 Css NA 0.2557 mg/L PBTK NA 50% Human Human -DTXSID7046205 Css NA 2.835 mg/L PBTK NA 95% Human Human -DTXSID7046205 Clint NA 11.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046205 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046205 Vd NA 0.9099 L/kg 1compartment NA NA Rat Human +DTXSID7046205 TK.Half.Life NA 11.65 hours 1compartment NA NA Human Human +DTXSID7046205 Css NA 0.3019 mg/L 3compartmentss NA 50% Human Human +DTXSID7046205 Css NA 2.193 mg/L 3compartmentss NA 95% Human Human +DTXSID7046205 Css NA 0.2407 mg/L PBTK NA 50% Human Human +DTXSID7046205 Css NA 1.619 mg/L PBTK NA 95% Human Human +DTXSID7046205 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046205 Fup 0.0558 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046205 Vd NA 2.892 L/kg 1compartment NA NA Rat Human DTXSID7046205 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046205 TK.Half.Life NA 1.743 hours 1compartment NA NA Rat Human -DTXSID7046205 Css NA 0.2224 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046205 Css NA 2.034 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046205 Css NA 0.1397 mg/L PBTK NA 50% Rat Human -DTXSID7046205 Css NA 1.193 mg/L PBTK NA 95% Rat Human -DTXSID7046207 Clint NA 22.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046207 Fup NA 0.0299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046207 Vd NA 1.171 L/kg 1compartment NA NA Human Human +DTXSID7046205 TK.Half.Life NA 2.945 hours 1compartment NA NA Rat Human +DTXSID7046205 Css NA 0.03885 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046205 Css NA 0.2296 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046205 Css NA 0.03116 mg/L PBTK NA 50% Rat Human +DTXSID7046205 Css NA 0.1725 mg/L PBTK NA 95% Rat Human +DTXSID7046207 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046207 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046207 Vd NA 0.7607 L/kg 1compartment NA NA Human Human DTXSID7046207 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046207 TK.Half.Life NA 7.352 hours 1compartment NA NA Human Human -DTXSID7046207 Css NA 0.9577 mg/L 3compartmentss NA 50% Human Human -DTXSID7046207 Css NA 8.814 mg/L 3compartmentss NA 95% Human Human -DTXSID7046207 Css NA 0.6016 mg/L PBTK NA 50% Human Human -DTXSID7046207 Css NA 5.28 mg/L PBTK NA 95% Human Human -DTXSID7046207 Clint NA 22.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046207 Fup NA 0.0299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046207 Vd NA 0.9205 L/kg 1compartment NA NA Rat Human +DTXSID7046207 TK.Half.Life NA 1.923 hours 1compartment NA NA Human Human +DTXSID7046207 Css NA 0.219 mg/L 3compartmentss NA 50% Human Human +DTXSID7046207 Css NA 1.415 mg/L 3compartmentss NA 95% Human Human +DTXSID7046207 Css NA 0.158 mg/L PBTK NA 50% Human Human +DTXSID7046207 Css NA 0.9294 mg/L PBTK NA 95% Human Human +DTXSID7046207 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046207 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046207 Vd NA 0.7586 L/kg 1compartment NA NA Rat Human DTXSID7046207 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046207 TK.Half.Life NA 3.344 hours 1compartment NA NA Rat Human -DTXSID7046207 Css NA 0.5474 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046207 Css NA 4.097 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046207 Css NA 0.3218 mg/L PBTK NA 50% Rat Human -DTXSID7046207 Css NA 2.274 mg/L PBTK NA 95% Rat Human -DTXSID7046251 Clint NA 0.3943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046251 Fup NA 0.2732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046251 Vd NA 0.7246 L/kg 1compartment NA NA Human Human -DTXSID7046251 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7046251 TK.Half.Life NA 10.7 hours 1compartment NA NA Human Human -DTXSID7046251 Css NA 1.652 mg/L 3compartmentss NA 50% Human Human -DTXSID7046251 Css NA 6.693 mg/L 3compartmentss NA 95% Human Human -DTXSID7046251 Css NA 1.189 mg/L PBTK NA 50% Human Human -DTXSID7046251 Css NA 4.263 mg/L PBTK NA 95% Human Human -DTXSID7046251 Clint NA 0.3943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046251 Fup NA 0.2732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046251 Vd NA 0.6552 L/kg 1compartment NA NA Rat Human +DTXSID7046207 TK.Half.Life NA 1.098 hours 1compartment NA NA Rat Human +DTXSID7046207 Css NA 0.02574 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046207 Css NA 0.1201 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046207 Css NA 0.01856 mg/L PBTK NA 50% Rat Human +DTXSID7046207 Css NA 0.07702 mg/L PBTK NA 95% Rat Human +DTXSID7046251 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046251 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046251 Vd NA 1.01 L/kg 1compartment NA NA Human Human +DTXSID7046251 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7046251 TK.Half.Life NA 0.9074 hours 1compartment NA NA Human Human +DTXSID7046251 Css NA 0.03311 mg/L 3compartmentss NA 50% Human Human +DTXSID7046251 Css NA 0.3627 mg/L 3compartmentss NA 95% Human Human +DTXSID7046251 Css NA 0.02752 mg/L PBTK NA 50% Human Human +DTXSID7046251 Css NA 0.2468 mg/L PBTK NA 95% Human Human +DTXSID7046251 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046251 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046251 Vd NA 0.9397 L/kg 1compartment NA NA Rat Human DTXSID7046251 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046251 TK.Half.Life NA 4.037 hours 1compartment NA NA Rat Human -DTXSID7046251 Css NA 0.5798 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046251 Css NA 1.95 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046251 Css NA 0.3962 mg/L PBTK NA 50% Rat Human -DTXSID7046251 Css NA 1.153 mg/L PBTK NA 95% Rat Human -DTXSID7046253 Clint NA 38.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046253 Fup NA 0.0489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046253 Vd NA 2.063 L/kg 1compartment NA NA Human Human +DTXSID7046251 TK.Half.Life NA 0.4176 hours 1compartment NA NA Rat Human +DTXSID7046251 Css NA 0.004044 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046251 Css NA 0.03716 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046251 Css NA 0.003382 mg/L PBTK NA 50% Rat Human +DTXSID7046251 Css NA 0.02499 mg/L PBTK NA 95% Rat Human +DTXSID7046253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046253 Fup 0.0415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046253 Vd NA 1.589 L/kg 1compartment NA NA Human Human DTXSID7046253 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046253 TK.Half.Life NA 7.475 hours 1compartment NA NA Human Human -DTXSID7046253 Css NA 0.4393 mg/L 3compartmentss NA 50% Human Human -DTXSID7046253 Css NA 3.366 mg/L 3compartmentss NA 95% Human Human -DTXSID7046253 Css NA 0.2885 mg/L PBTK NA 50% Human Human -DTXSID7046253 Css NA 2.105 mg/L PBTK NA 95% Human Human -DTXSID7046253 Clint NA 38.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046253 Fup NA 0.0489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046253 Vd NA 1.543 L/kg 1compartment NA NA Rat Human +DTXSID7046253 TK.Half.Life NA 8.741 hours 1compartment NA NA Human Human +DTXSID7046253 Css NA 0.7832 mg/L 3compartmentss NA 50% Human Human +DTXSID7046253 Css NA 6.535 mg/L 3compartmentss NA 95% Human Human +DTXSID7046253 Css NA 0.4982 mg/L PBTK NA 50% Human Human +DTXSID7046253 Css NA 3.918 mg/L PBTK NA 95% Human Human +DTXSID7046253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046253 Fup 0.0415 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046253 Vd NA 1.187 L/kg 1compartment NA NA Rat Human DTXSID7046253 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046253 TK.Half.Life NA 2.387 hours 1compartment NA NA Rat Human -DTXSID7046253 Css NA 0.2455 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046253 Css NA 1.458 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046253 Css NA 0.1527 mg/L PBTK NA 50% Rat Human -DTXSID7046253 Css NA 0.8691 mg/L PBTK NA 95% Rat Human -DTXSID7046257 Clint NA 15.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046257 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046257 Vd NA 1.25 L/kg 1compartment NA NA Human Human +DTXSID7046253 TK.Half.Life NA 3.27 hours 1compartment NA NA Rat Human +DTXSID7046253 Css NA 0.1018 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046253 Css NA 0.6754 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046253 Css NA 0.0631 mg/L PBTK NA 50% Rat Human +DTXSID7046253 Css NA 0.4011 mg/L PBTK NA 95% Rat Human +DTXSID7046257 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046257 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046257 Vd NA 1.586 L/kg 1compartment NA NA Human Human DTXSID7046257 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046257 TK.Half.Life NA 5.879 hours 1compartment NA NA Human Human -DTXSID7046257 Css NA 0.6128 mg/L 3compartmentss NA 50% Human Human -DTXSID7046257 Css NA 4.225 mg/L 3compartmentss NA 95% Human Human -DTXSID7046257 Css NA 0.3935 mg/L PBTK NA 50% Human Human -DTXSID7046257 Css NA 2.578 mg/L PBTK NA 95% Human Human -DTXSID7046257 Clint NA 15.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046257 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046257 Vd NA 0.9524 L/kg 1compartment NA NA Rat Human +DTXSID7046257 TK.Half.Life NA 4.176 hours 1compartment NA NA Human Human +DTXSID7046257 Css NA 0.2696 mg/L 3compartmentss NA 50% Human Human +DTXSID7046257 Css NA 2.073 mg/L 3compartmentss NA 95% Human Human +DTXSID7046257 Css NA 0.1812 mg/L PBTK NA 50% Human Human +DTXSID7046257 Css NA 1.306 mg/L PBTK NA 95% Human Human +DTXSID7046257 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046257 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046257 Vd NA 1.216 L/kg 1compartment NA NA Rat Human DTXSID7046257 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046257 TK.Half.Life NA 2.439 hours 1compartment NA NA Rat Human -DTXSID7046257 Css NA 0.3404 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046257 Css NA 1.698 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046257 Css NA 0.2054 mg/L PBTK NA 50% Rat Human -DTXSID7046257 Css NA 0.9831 mg/L PBTK NA 95% Rat Human -DTXSID7046259 Clint NA 5.957 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046259 Fup NA 0.5298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046259 Vd NA 1.159 L/kg 1compartment NA NA Human Human +DTXSID7046257 TK.Half.Life NA 1.584 hours 1compartment NA NA Rat Human +DTXSID7046257 Css NA 0.03462 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046257 Css NA 0.207 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046257 Css NA 0.02282 mg/L PBTK NA 50% Rat Human +DTXSID7046257 Css NA 0.1292 mg/L PBTK NA 95% Rat Human +DTXSID7046259 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046259 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046259 Vd NA 0.6764 L/kg 1compartment NA NA Human Human DTXSID7046259 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046259 TK.Half.Life NA 1.997 hours 1compartment NA NA Human Human -DTXSID7046259 Css NA 0.1314 mg/L 3compartmentss NA 50% Human Human -DTXSID7046259 Css NA 1.045 mg/L 3compartmentss NA 95% Human Human -DTXSID7046259 Css NA 0.109 mg/L PBTK NA 50% Human Human -DTXSID7046259 Css NA 0.7199 mg/L PBTK NA 95% Human Human -DTXSID7046259 Clint NA 5.957 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046259 Fup NA 0.5298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046259 Vd NA 1.03 L/kg 1compartment NA NA Rat Human +DTXSID7046259 TK.Half.Life NA 1.49 hours 1compartment NA NA Human Human +DTXSID7046259 Css NA 0.1811 mg/L 3compartmentss NA 50% Human Human +DTXSID7046259 Css NA 1.196 mg/L 3compartmentss NA 95% Human Human +DTXSID7046259 Css NA 0.1333 mg/L PBTK NA 50% Human Human +DTXSID7046259 Css NA 0.7914 mg/L PBTK NA 95% Human Human +DTXSID7046259 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046259 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046259 Vd NA 0.6408 L/kg 1compartment NA NA Rat Human DTXSID7046259 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046259 TK.Half.Life NA 0.9353 hours 1compartment NA NA Rat Human -DTXSID7046259 Css NA 0.06665 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046259 Css NA 0.4168 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046259 Css NA 0.0531 mg/L PBTK NA 50% Rat Human -DTXSID7046259 Css NA 0.2635 mg/L PBTK NA 95% Rat Human -DTXSID7046384 Clint NA 26.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046384 Fup NA 0.5067 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046384 Vd NA 0.8614 L/kg 1compartment NA NA Human Human +DTXSID7046259 TK.Half.Life NA 0.7897 hours 1compartment NA NA Rat Human +DTXSID7046259 Css NA 0.02118 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046259 Css NA 0.1049 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046259 Css NA 0.0155 mg/L PBTK NA 50% Rat Human +DTXSID7046259 Css NA 0.06798 mg/L PBTK NA 95% Rat Human +DTXSID7046384 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046384 Fup 0.492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046384 Vd NA 0.8436 L/kg 1compartment NA NA Human Human DTXSID7046384 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046384 TK.Half.Life NA 0.79 hours 1compartment NA NA Human Human -DTXSID7046384 Css NA 0.03298 mg/L 3compartmentss NA 50% Human Human -DTXSID7046384 Css NA 0.2909 mg/L 3compartmentss NA 95% Human Human -DTXSID7046384 Css NA 0.02602 mg/L PBTK NA 50% Human Human -DTXSID7046384 Css NA 0.1979 mg/L PBTK NA 95% Human Human -DTXSID7046384 Clint NA 26.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046384 Fup NA 0.5067 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046384 Vd NA 0.8309 L/kg 1compartment NA NA Rat Human +DTXSID7046384 TK.Half.Life NA 1.463 hours 1compartment NA NA Human Human +DTXSID7046384 Css NA 0.1322 mg/L 3compartmentss NA 50% Human Human +DTXSID7046384 Css NA 0.9158 mg/L 3compartmentss NA 95% Human Human +DTXSID7046384 Css NA 0.1042 mg/L PBTK NA 50% Human Human +DTXSID7046384 Css NA 0.6287 mg/L PBTK NA 95% Human Human +DTXSID7046384 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046384 Fup 0.492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046384 Vd NA 0.7965 L/kg 1compartment NA NA Rat Human DTXSID7046384 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046384 TK.Half.Life NA 0.3769 hours 1compartment NA NA Rat Human -DTXSID7046384 Css NA 0.01733 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046384 Css NA 0.1334 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046384 Css NA 0.01329 mg/L PBTK NA 50% Rat Human -DTXSID7046384 Css NA 0.08743 mg/L PBTK NA 95% Rat Human -DTXSID7046386 Clint NA 18.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046386 Fup NA 0.0262 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046386 Vd NA 1.697 L/kg 1compartment NA NA Human Human -DTXSID7046386 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7046386 TK.Half.Life NA 15.58 hours 1compartment NA NA Human Human -DTXSID7046386 Css NA 1.426 mg/L 3compartmentss NA 50% Human Human -DTXSID7046386 Css NA 11.42 mg/L 3compartmentss NA 95% Human Human -DTXSID7046386 Css NA 0.9048 mg/L PBTK NA 50% Human Human -DTXSID7046386 Css NA 6.995 mg/L PBTK NA 95% Human Human -DTXSID7046386 Clint NA 18.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046386 Fup NA 0.0262 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046386 Vd NA 1.262 L/kg 1compartment NA NA Rat Human +DTXSID7046384 TK.Half.Life NA 0.7518 hours 1compartment NA NA Rat Human +DTXSID7046384 Css NA 0.01474 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046384 Css NA 0.08878 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046384 Css NA 0.01167 mg/L PBTK NA 50% Rat Human +DTXSID7046384 Css NA 0.05763 mg/L PBTK NA 95% Rat Human +DTXSID7046386 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046386 Fup 0.036 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046386 Vd NA 1.91 L/kg 1compartment NA NA Human Human +DTXSID7046386 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7046386 TK.Half.Life NA 12.69 hours 1compartment NA NA Human Human +DTXSID7046386 Css NA 0.9276 mg/L 3compartmentss NA 50% Human Human +DTXSID7046386 Css NA 6.883 mg/L 3compartmentss NA 95% Human Human +DTXSID7046386 Css NA 0.597 mg/L PBTK NA 50% Human Human +DTXSID7046386 Css NA 4.27 mg/L PBTK NA 95% Human Human +DTXSID7046386 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046386 Fup 0.036 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046386 Vd NA 1.426 L/kg 1compartment NA NA Rat Human DTXSID7046386 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046386 TK.Half.Life NA 5.631 hours 1compartment NA NA Rat Human -DTXSID7046386 Css NA 0.7945 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046386 Css NA 5.163 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046386 Css NA 0.4756 mg/L PBTK NA 50% Rat Human -DTXSID7046386 Css NA 2.921 mg/L PBTK NA 95% Rat Human -DTXSID7046388 Clint NA 0.9762 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046388 Fup NA 0.283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046388 Vd NA 0.9359 L/kg 1compartment NA NA Human Human +DTXSID7046386 TK.Half.Life NA 4.26 hours 1compartment NA NA Rat Human +DTXSID7046386 Css NA 0.1212 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046386 Css NA 0.7172 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046386 Css NA 0.07634 mg/L PBTK NA 50% Rat Human +DTXSID7046386 Css NA 0.4348 mg/L PBTK NA 95% Rat Human +DTXSID7046388 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046388 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046388 Vd NA 0.7522 L/kg 1compartment NA NA Human Human DTXSID7046388 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046388 TK.Half.Life NA 8.77 hours 1compartment NA NA Human Human -DTXSID7046388 Css NA 1.022 mg/L 3compartmentss NA 50% Human Human -DTXSID7046388 Css NA 4.581 mg/L 3compartmentss NA 95% Human Human -DTXSID7046388 Css NA 0.7488 mg/L PBTK NA 50% Human Human -DTXSID7046388 Css NA 2.971 mg/L PBTK NA 95% Human Human -DTXSID7046388 Clint NA 0.9762 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046388 Fup NA 0.283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046388 Vd NA 0.8268 L/kg 1compartment NA NA Rat Human +DTXSID7046388 TK.Half.Life NA 2.823 hours 1compartment NA NA Human Human +DTXSID7046388 Css NA 0.3755 mg/L 3compartmentss NA 50% Human Human +DTXSID7046388 Css NA 2.286 mg/L 3compartmentss NA 95% Human Human +DTXSID7046388 Css NA 0.2582 mg/L PBTK NA 50% Human Human +DTXSID7046388 Css NA 1.444 mg/L PBTK NA 95% Human Human +DTXSID7046388 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046388 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046388 Vd NA 0.6603 L/kg 1compartment NA NA Rat Human DTXSID7046388 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046388 TK.Half.Life NA 3.66 hours 1compartment NA NA Rat Human -DTXSID7046388 Css NA 0.4128 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046388 Css NA 1.451 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046388 Css NA 0.2919 mg/L PBTK NA 50% Rat Human -DTXSID7046388 Css NA 0.8802 mg/L PBTK NA 95% Rat Human -DTXSID7046411 Clint NA 0.3297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046411 Fup NA 0.4902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046411 Vd NA 2.344 L/kg 1compartment NA NA Human Human -DTXSID7046411 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID7046411 TK.Half.Life NA 39.93 hours 1compartment NA NA Human Human -DTXSID7046411 Css NA 1.723 mg/L 3compartmentss NA 50% Human Human -DTXSID7046411 Css NA 6.828 mg/L 3compartmentss NA 95% Human Human -DTXSID7046411 Css NA 1.411 mg/L PBTK NA 50% Human Human -DTXSID7046411 Css NA 4.683 mg/L PBTK NA 95% Human Human -DTXSID7046411 Clint NA 0.3297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046411 Fup NA 0.4902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046411 Vd NA 1.851 L/kg 1compartment NA NA Rat Human -DTXSID7046411 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7046411 TK.Half.Life NA 8.074 hours 1compartment NA NA Rat Human -DTXSID7046411 Css NA 0.5883 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046411 Css NA 1.949 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046411 Css NA 0.4665 mg/L PBTK NA 50% Rat Human -DTXSID7046411 Css NA 1.245 mg/L PBTK NA 95% Rat Human -DTXSID7046413 Clint NA 41.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046413 Fup NA 0.3699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046413 Vd NA 0.8225 L/kg 1compartment NA NA Human Human +DTXSID7046388 TK.Half.Life NA 1.431 hours 1compartment NA NA Rat Human +DTXSID7046388 Css NA 0.04499 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046388 Css NA 0.1949 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046388 Css NA 0.03042 mg/L PBTK NA 50% Rat Human +DTXSID7046388 Css NA 0.1226 mg/L PBTK NA 95% Rat Human +DTXSID7046411 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046411 Fup 0.227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046411 Vd NA 1.775 L/kg 1compartment NA NA Human Human +DTXSID7046411 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7046411 TK.Half.Life NA 3.103 hours 1compartment NA NA Human Human +DTXSID7046411 Css NA 0.1179 mg/L 3compartmentss NA 50% Human Human +DTXSID7046411 Css NA 0.7994 mg/L 3compartmentss NA 95% Human Human +DTXSID7046411 Css NA 0.08673 mg/L PBTK NA 50% Human Human +DTXSID7046411 Css NA 0.5482 mg/L PBTK NA 95% Human Human +DTXSID7046411 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046411 Fup 0.227 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046411 Vd NA 1.388 L/kg 1compartment NA NA Rat Human +DTXSID7046411 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7046411 TK.Half.Life NA 1.137 hours 1compartment NA NA Rat Human +DTXSID7046411 Css NA 0.01511 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046411 Css NA 0.07955 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046411 Css NA 0.011 mg/L PBTK NA 50% Rat Human +DTXSID7046411 Css NA 0.05435 mg/L PBTK NA 95% Rat Human +DTXSID7046413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046413 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046413 Vd NA 1.487 L/kg 1compartment NA NA Human Human DTXSID7046413 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046413 TK.Half.Life NA 0.7853 hours 1compartment NA NA Human Human -DTXSID7046413 Css NA 0.02983 mg/L 3compartmentss NA 50% Human Human -DTXSID7046413 Css NA 0.2389 mg/L 3compartmentss NA 95% Human Human -DTXSID7046413 Css NA 0.02262 mg/L PBTK NA 50% Human Human -DTXSID7046413 Css NA 0.1615 mg/L PBTK NA 95% Human Human -DTXSID7046413 Clint NA 41.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046413 Fup NA 0.3699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046413 Vd NA 0.7513 L/kg 1compartment NA NA Rat Human +DTXSID7046413 TK.Half.Life NA 3.411 hours 1compartment NA NA Human Human +DTXSID7046413 Css NA 0.212 mg/L 3compartmentss NA 50% Human Human +DTXSID7046413 Css NA 1.704 mg/L 3compartmentss NA 95% Human Human +DTXSID7046413 Css NA 0.1449 mg/L PBTK NA 50% Human Human +DTXSID7046413 Css NA 1.092 mg/L PBTK NA 95% Human Human +DTXSID7046413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046413 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046413 Vd NA 1.152 L/kg 1compartment NA NA Rat Human DTXSID7046413 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046413 TK.Half.Life NA 0.3506 hours 1compartment NA NA Rat Human -DTXSID7046413 Css NA 0.01643 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046413 Css NA 0.1032 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046413 Css NA 0.0119 mg/L PBTK NA 50% Rat Human -DTXSID7046413 Css NA 0.06891 mg/L PBTK NA 95% Rat Human -DTXSID7046415 Clint NA 57.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046415 Fup NA 0.1661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046415 Vd NA 4.253 L/kg 1compartment NA NA Human Human +DTXSID7046413 TK.Half.Life NA 1.331 hours 1compartment NA NA Rat Human +DTXSID7046413 Css NA 0.02785 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046413 Css NA 0.1628 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046413 Css NA 0.01862 mg/L PBTK NA 50% Rat Human +DTXSID7046413 Css NA 0.1014 mg/L PBTK NA 95% Rat Human +DTXSID7046415 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046415 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046415 Vd NA 3.499 L/kg 1compartment NA NA Human Human DTXSID7046415 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046415 TK.Half.Life NA 3.19 hours 1compartment NA NA Human Human -DTXSID7046415 Css NA 0.02271 mg/L 3compartmentss NA 50% Human Human -DTXSID7046415 Css NA 0.179 mg/L 3compartmentss NA 95% Human Human -DTXSID7046415 Css NA 0.02516 mg/L PBTK NA 50% Human Human -DTXSID7046415 Css NA 0.1658 mg/L PBTK NA 95% Human Human -DTXSID7046415 Clint NA 57.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046415 Fup NA 0.1661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046415 Vd NA 4.037 L/kg 1compartment NA NA Rat Human +DTXSID7046415 TK.Half.Life NA 4.82 hours 1compartment NA NA Human Human +DTXSID7046415 Css NA 0.08517 mg/L 3compartmentss NA 50% Human Human +DTXSID7046415 Css NA 0.8218 mg/L 3compartmentss NA 95% Human Human +DTXSID7046415 Css NA 0.08426 mg/L PBTK NA 50% Human Human +DTXSID7046415 Css NA 0.6709 mg/L PBTK NA 95% Human Human +DTXSID7046415 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046415 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046415 Vd NA 3.385 L/kg 1compartment NA NA Rat Human DTXSID7046415 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046415 TK.Half.Life NA 1.376 hours 1compartment NA NA Rat Human -DTXSID7046415 Css NA 0.01202 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046415 Css NA 0.08264 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046415 Css NA 0.01328 mg/L PBTK NA 50% Rat Human -DTXSID7046415 Css NA 0.07598 mg/L PBTK NA 95% Rat Human -DTXSID7046417 Clint NA 10.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046417 Fup NA 0.0996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046417 Vd NA 0.4818 L/kg 1compartment NA NA Human Human +DTXSID7046415 TK.Half.Life NA 2.45 hours 1compartment NA NA Rat Human +DTXSID7046415 Css NA 0.01078 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046415 Css NA 0.08032 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046415 Css NA 0.0108 mg/L PBTK NA 50% Rat Human +DTXSID7046415 Css NA 0.06352 mg/L PBTK NA 95% Rat Human +DTXSID7046417 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046417 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046417 Vd NA 0.6622 L/kg 1compartment NA NA Human Human DTXSID7046417 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046417 TK.Half.Life NA 2.106 hours 1compartment NA NA Human Human -DTXSID7046417 Css NA 0.6 mg/L 3compartmentss NA 50% Human Human -DTXSID7046417 Css NA 4.517 mg/L 3compartmentss NA 95% Human Human -DTXSID7046417 Css NA 0.374 mg/L PBTK NA 50% Human Human -DTXSID7046417 Css NA 2.67 mg/L PBTK NA 95% Human Human -DTXSID7046417 Clint NA 10.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046417 Fup NA 0.0996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046417 Vd NA 0.4112 L/kg 1compartment NA NA Rat Human +DTXSID7046417 TK.Half.Life NA 1.237 hours 1compartment NA NA Human Human +DTXSID7046417 Css NA 0.1439 mg/L 3compartmentss NA 50% Human Human +DTXSID7046417 Css NA 1.015 mg/L 3compartmentss NA 95% Human Human +DTXSID7046417 Css NA 0.09444 mg/L PBTK NA 50% Human Human +DTXSID7046417 Css NA 0.6314 mg/L PBTK NA 95% Human Human +DTXSID7046417 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046417 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046417 Vd NA 0.558 L/kg 1compartment NA NA Rat Human DTXSID7046417 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046417 TK.Half.Life NA 1.087 hours 1compartment NA NA Rat Human -DTXSID7046417 Css NA 0.3292 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046417 Css NA 1.799 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046417 Css NA 0.1921 mg/L PBTK NA 50% Rat Human -DTXSID7046417 Css NA 1.011 mg/L PBTK NA 95% Rat Human -DTXSID7046419 Clint NA 2.638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046419 Fup NA 0.6195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046419 Vd NA 0.873 L/kg 1compartment NA NA Human Human +DTXSID7046417 TK.Half.Life NA 0.5776 hours 1compartment NA NA Rat Human +DTXSID7046417 Css NA 0.01844 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046417 Css NA 0.1029 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046417 Css NA 0.01189 mg/L PBTK NA 50% Rat Human +DTXSID7046417 Css NA 0.06312 mg/L PBTK NA 95% Rat Human +DTXSID7046419 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046419 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046419 Vd NA 0.6728 L/kg 1compartment NA NA Human Human DTXSID7046419 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046419 TK.Half.Life NA 2.086 hours 1compartment NA NA Human Human -DTXSID7046419 Css NA 0.2326 mg/L 3compartmentss NA 50% Human Human -DTXSID7046419 Css NA 1.793 mg/L 3compartmentss NA 95% Human Human -DTXSID7046419 Css NA 0.1906 mg/L PBTK NA 50% Human Human -DTXSID7046419 Css NA 1.175 mg/L PBTK NA 95% Human Human -DTXSID7046419 Clint NA 2.638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046419 Fup NA 0.6195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046419 Vd NA 0.8445 L/kg 1compartment NA NA Rat Human +DTXSID7046419 TK.Half.Life NA 0.7555 hours 1compartment NA NA Human Human +DTXSID7046419 Css NA 0.04848 mg/L 3compartmentss NA 50% Human Human +DTXSID7046419 Css NA 0.4189 mg/L 3compartmentss NA 95% Human Human +DTXSID7046419 Css NA 0.03638 mg/L PBTK NA 50% Human Human +DTXSID7046419 Css NA 0.2798 mg/L PBTK NA 95% Human Human +DTXSID7046419 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046419 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046419 Vd NA 0.6494 L/kg 1compartment NA NA Rat Human DTXSID7046419 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046419 TK.Half.Life NA 1.07 hours 1compartment NA NA Rat Human -DTXSID7046419 Css NA 0.1032 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046419 Css NA 0.7211 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046419 Css NA 0.08272 mg/L PBTK NA 50% Rat Human -DTXSID7046419 Css NA 0.4332 mg/L PBTK NA 95% Rat Human -DTXSID7046461 Clint NA 93.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046461 Fup NA 0.0947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046461 Vd NA 2.508 L/kg 1compartment NA NA Human Human -DTXSID7046461 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046461 TK.Half.Life NA 2.821 hours 1compartment NA NA Human Human -DTXSID7046461 Css NA 0.05773 mg/L 3compartmentss NA 50% Human Human -DTXSID7046461 Css NA 0.4708 mg/L 3compartmentss NA 95% Human Human -DTXSID7046461 Css NA 0.04432 mg/L PBTK NA 50% Human Human -DTXSID7046461 Css NA 0.3284 mg/L PBTK NA 95% Human Human -DTXSID7046461 Clint NA 93.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046461 Fup NA 0.0947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046461 Vd NA 2.198 L/kg 1compartment NA NA Rat Human -DTXSID7046461 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046461 TK.Half.Life NA 1.159 hours 1compartment NA NA Rat Human -DTXSID7046461 Css NA 0.03226 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046461 Css NA 0.2134 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046461 Css NA 0.02391 mg/L PBTK NA 50% Rat Human -DTXSID7046461 Css NA 0.1392 mg/L PBTK NA 95% Rat Human -DTXSID7046463 Clint NA 66.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046463 Fup NA 0.1227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046463 Vd NA 2.833 L/kg 1compartment NA NA Human Human -DTXSID7046463 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046463 TK.Half.Life NA 6.843 hours 1compartment NA NA Human Human -DTXSID7046463 Css NA 0.2121 mg/L 3compartmentss NA 50% Human Human -DTXSID7046463 Css NA 1.387 mg/L 3compartmentss NA 95% Human Human -DTXSID7046463 Css NA 0.1478 mg/L PBTK NA 50% Human Human -DTXSID7046463 Css NA 0.9425 mg/L PBTK NA 95% Human Human -DTXSID7046463 Clint NA 66.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046463 Fup NA 0.1227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046463 Vd NA 2.133 L/kg 1compartment NA NA Rat Human +DTXSID7046419 TK.Half.Life NA 0.3755 hours 1compartment NA NA Rat Human +DTXSID7046419 Css NA 0.006016 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046419 Css NA 0.03827 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046419 Css NA 0.004482 mg/L PBTK NA 50% Rat Human +DTXSID7046419 Css NA 0.02497 mg/L PBTK NA 95% Rat Human +DTXSID7046461 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046461 Fup 0.0846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046461 Vd NA 2.687 L/kg 1compartment NA NA Human Human +DTXSID7046461 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7046461 TK.Half.Life NA 21.01 hours 1compartment NA NA Human Human +DTXSID7046461 Css NA 0.9238 mg/L 3compartmentss NA 50% Human Human +DTXSID7046461 Css NA 6.26 mg/L 3compartmentss NA 95% Human Human +DTXSID7046461 Css NA 0.706 mg/L PBTK NA 50% Human Human +DTXSID7046461 Css NA 4.312 mg/L PBTK NA 95% Human Human +DTXSID7046461 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046461 Fup 0.0846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046461 Vd NA 2.288 L/kg 1compartment NA NA Rat Human +DTXSID7046461 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7046461 TK.Half.Life NA 7.859 hours 1compartment NA NA Rat Human +DTXSID7046461 Css NA 0.1134 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046461 Css NA 0.5687 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046461 Css NA 0.08644 mg/L PBTK NA 50% Rat Human +DTXSID7046461 Css NA 0.3906 mg/L PBTK NA 95% Rat Human +DTXSID7046463 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046463 Fup 0.025 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046463 Vd NA 2.047 L/kg 1compartment NA NA Human Human +DTXSID7046463 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7046463 TK.Half.Life NA 18.27 hours 1compartment NA NA Human Human +DTXSID7046463 Css NA 1.295 mg/L 3compartmentss NA 50% Human Human +DTXSID7046463 Css NA 10.56 mg/L 3compartmentss NA 95% Human Human +DTXSID7046463 Css NA 0.8326 mg/L PBTK NA 50% Human Human +DTXSID7046463 Css NA 6.587 mg/L PBTK NA 95% Human Human +DTXSID7046463 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046463 Fup 0.025 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046463 Vd NA 1.524 L/kg 1compartment NA NA Rat Human DTXSID7046463 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046463 TK.Half.Life NA 1.612 hours 1compartment NA NA Rat Human -DTXSID7046463 Css NA 0.1187 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046463 Css NA 0.6438 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046463 Css NA 0.07936 mg/L PBTK NA 50% Rat Human -DTXSID7046463 Css NA 0.4261 mg/L PBTK NA 95% Rat Human -DTXSID7046465 Clint NA 13.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046465 Fup NA 0.0947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046465 Vd NA 1.86 L/kg 1compartment NA NA Human Human +DTXSID7046463 TK.Half.Life NA 5.771 hours 1compartment NA NA Rat Human +DTXSID7046463 Css NA 0.1662 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046463 Css NA 1.06 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046463 Css NA 0.1051 mg/L PBTK NA 50% Rat Human +DTXSID7046463 Css NA 0.646 mg/L PBTK NA 95% Rat Human +DTXSID7046465 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046465 Fup 0.0423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046465 Vd NA 1.32 L/kg 1compartment NA NA Human Human DTXSID7046465 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046465 TK.Half.Life NA 8.527 hours 1compartment NA NA Human Human -DTXSID7046465 Css NA 0.5758 mg/L 3compartmentss NA 50% Human Human -DTXSID7046465 Css NA 3.915 mg/L 3compartmentss NA 95% Human Human -DTXSID7046465 Css NA 0.385 mg/L PBTK NA 50% Human Human -DTXSID7046465 Css NA 2.484 mg/L PBTK NA 95% Human Human -DTXSID7046465 Clint NA 13.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046465 Fup NA 0.0947 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046465 Vd NA 1.41 L/kg 1compartment NA NA Rat Human +DTXSID7046465 TK.Half.Life NA 6.782 hours 1compartment NA NA Human Human +DTXSID7046465 Css NA 0.7291 mg/L 3compartmentss NA 50% Human Human +DTXSID7046465 Css NA 6.363 mg/L 3compartmentss NA 95% Human Human +DTXSID7046465 Css NA 0.463 mg/L PBTK NA 50% Human Human +DTXSID7046465 Css NA 3.897 mg/L PBTK NA 95% Human Human +DTXSID7046465 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046465 Fup 0.0423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046465 Vd NA 0.9918 L/kg 1compartment NA NA Rat Human DTXSID7046465 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046465 TK.Half.Life NA 2.955 hours 1compartment NA NA Rat Human -DTXSID7046465 Css NA 0.316 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046465 Css NA 1.62 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046465 Css NA 0.2013 mg/L PBTK NA 50% Rat Human -DTXSID7046465 Css NA 0.9723 mg/L PBTK NA 95% Rat Human -DTXSID7046467 Clint NA 35.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7046465 TK.Half.Life NA 2.748 hours 1compartment NA NA Rat Human +DTXSID7046465 Css NA 0.09698 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046465 Css NA 0.639 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046465 Css NA 0.05939 mg/L PBTK NA 50% Rat Human +DTXSID7046465 Css NA 0.3748 mg/L PBTK NA 95% Rat Human +DTXSID7046467 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7046467 Fup 0.46 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7046467 Vd NA 0.5142 L/kg 1compartment NA NA Human Human +DTXSID7046467 Vd NA 1.017 L/kg 1compartment NA NA Human Human DTXSID7046467 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046467 TK.Half.Life NA 0.482 hours 1compartment NA NA Human Human -DTXSID7046467 Css NA 0.02924 mg/L 3compartmentss NA 50% Human Human -DTXSID7046467 Css NA 0.2444 mg/L 3compartmentss NA 95% Human Human -DTXSID7046467 Css NA 0.0214 mg/L PBTK NA 50% Human Human -DTXSID7046467 Css NA 0.1609 mg/L PBTK NA 95% Human Human -DTXSID7046467 Clint NA 35.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7046467 TK.Half.Life NA 1.877 hours 1compartment NA NA Human Human +DTXSID7046467 Css NA 0.06812 mg/L 3compartmentss NA 50% Human Human +DTXSID7046467 Css NA 0.5526 mg/L 3compartmentss NA 95% Human Human +DTXSID7046467 Css NA 0.05495 mg/L PBTK NA 50% Human Human +DTXSID7046467 Css NA 0.3911 mg/L PBTK NA 95% Human Human +DTXSID7046467 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7046467 Fup 0.46 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7046467 Vd NA 0.533 L/kg 1compartment NA NA Rat Human +DTXSID7046467 Vd NA 0.9154 L/kg 1compartment NA NA Rat Human DTXSID7046467 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046467 TK.Half.Life NA 0.2429 hours 1compartment NA NA Rat Human -DTXSID7046467 Css NA 0.01541 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046467 Css NA 0.1078 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046467 Css NA 0.01086 mg/L PBTK NA 50% Rat Human -DTXSID7046467 Css NA 0.06777 mg/L PBTK NA 95% Rat Human +DTXSID7046467 TK.Half.Life NA 0.91 hours 1compartment NA NA Rat Human +DTXSID7046467 Css NA 0.0006311 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046467 Css NA 0.004589 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046467 Css NA 0.000492 mg/L PBTK NA 50% Rat Human +DTXSID7046467 Css NA 0.003031 mg/L PBTK NA 95% Rat Human DTXSID7046540 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7046540 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7046540 Vd NA 0.4596 L/kg 1compartment NA NA Human Human DTXSID7046540 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID7046540 TK.Half.Life NA 2.975 hours 1compartment NA NA Human Human -DTXSID7046540 Css NA 0.9419 mg/L 3compartmentss NA 50% Human Human -DTXSID7046540 Css NA 5.756 mg/L 3compartmentss NA 95% Human Human -DTXSID7046540 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID7046540 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID7046540 Css NA 0.7952 mg/L 3compartmentss NA 50% Human Human +DTXSID7046540 Css NA 5.235 mg/L 3compartmentss NA 95% Human Human +DTXSID7046540 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID7046540 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID7046540 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7046540 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7046540 Vd NA 0.4913 L/kg 1compartment NA NA Rat Human DTXSID7046540 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7046540 TK.Half.Life NA 1.083 hours 1compartment NA NA Rat Human -DTXSID7046540 Css NA 0.2397 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046540 Css NA 1.384 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046540 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID7046540 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID7046542 Clint NA 14.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046542 Fup NA 0.1172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046542 Vd NA 1.207 L/kg 1compartment NA NA Human Human +DTXSID7046540 Css NA 0.01472 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046540 Css NA 0.1057 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046540 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID7046540 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID7046542 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046542 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046542 Vd NA 1.294 L/kg 1compartment NA NA Human Human DTXSID7046542 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046542 TK.Half.Life NA 3.781 hours 1compartment NA NA Human Human -DTXSID7046542 Css NA 0.368 mg/L 3compartmentss NA 50% Human Human -DTXSID7046542 Css NA 2.66 mg/L 3compartmentss NA 95% Human Human -DTXSID7046542 Css NA 0.2454 mg/L PBTK NA 50% Human Human -DTXSID7046542 Css NA 1.663 mg/L PBTK NA 95% Human Human -DTXSID7046542 Clint NA 14.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046542 Fup NA 0.1172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046542 Vd NA 0.9433 L/kg 1compartment NA NA Rat Human +DTXSID7046542 TK.Half.Life NA 7.023 hours 1compartment NA NA Human Human +DTXSID7046542 Css NA 0.6828 mg/L 3compartmentss NA 50% Human Human +DTXSID7046542 Css NA 4.488 mg/L 3compartmentss NA 95% Human Human +DTXSID7046542 Css NA 0.4609 mg/L PBTK NA 50% Human Human +DTXSID7046542 Css NA 2.8 mg/L PBTK NA 95% Human Human +DTXSID7046542 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046542 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046542 Vd NA 1.013 L/kg 1compartment NA NA Rat Human DTXSID7046542 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046542 TK.Half.Life NA 1.598 hours 1compartment NA NA Rat Human -DTXSID7046542 Css NA 0.201 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046542 Css NA 1.121 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046542 Css NA 0.1259 mg/L PBTK NA 50% Rat Human -DTXSID7046542 Css NA 0.6627 mg/L PBTK NA 95% Rat Human -DTXSID7046592 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046592 Fup NA 0.4001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046592 Vd NA 1.501 L/kg 1compartment NA NA Human Human -DTXSID7046592 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7046592 TK.Half.Life NA 24.27 hours 1compartment NA NA Human Human -DTXSID7046592 Css NA 1.469 mg/L 3compartmentss NA 50% Human Human -DTXSID7046592 Css NA 7.329 mg/L 3compartmentss NA 95% Human Human -DTXSID7046592 Css NA 1.334 mg/L PBTK NA 50% Human Human -DTXSID7046592 Css NA 5.156 mg/L PBTK NA 95% Human Human -DTXSID7046592 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046592 Fup NA 0.4001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046592 Vd NA 1.473 L/kg 1compartment NA NA Rat Human +DTXSID7046542 TK.Half.Life NA 2.898 hours 1compartment NA NA Rat Human +DTXSID7046542 Css NA 0.08276 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046542 Css NA 0.4055 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046542 Css NA 0.05467 mg/L PBTK NA 50% Rat Human +DTXSID7046542 Css NA 0.2491 mg/L PBTK NA 95% Rat Human +DTXSID7046592 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046592 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046592 Vd NA 1.054 L/kg 1compartment NA NA Human Human +DTXSID7046592 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7046592 TK.Half.Life NA 3.135 hours 1compartment NA NA Human Human +DTXSID7046592 Css NA 0.1344 mg/L 3compartmentss NA 50% Human Human +DTXSID7046592 Css NA 0.923 mg/L 3compartmentss NA 95% Human Human +DTXSID7046592 Css NA 0.1044 mg/L PBTK NA 50% Human Human +DTXSID7046592 Css NA 0.6406 mg/L PBTK NA 95% Human Human +DTXSID7046592 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046592 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046592 Vd NA 1.025 L/kg 1compartment NA NA Rat Human DTXSID7046592 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046592 TK.Half.Life NA 8.116 hours 1compartment NA NA Rat Human -DTXSID7046592 Css NA 0.3916 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046592 Css NA 1.691 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046592 Css NA 0.3475 mg/L PBTK NA 50% Rat Human -DTXSID7046592 Css NA 1.099 mg/L PBTK NA 95% Rat Human -DTXSID7046594 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046594 Fup NA 0.4505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046594 Vd NA 0.3669 L/kg 1compartment NA NA Human Human +DTXSID7046592 TK.Half.Life NA 1.796 hours 1compartment NA NA Rat Human +DTXSID7046592 Css NA 0.001279 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046592 Css NA 0.007783 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046592 Css NA 0.0009574 mg/L PBTK NA 50% Rat Human +DTXSID7046592 Css NA 0.00512 mg/L PBTK NA 95% Rat Human +DTXSID7046594 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046594 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046594 Vd NA 0.384 L/kg 1compartment NA NA Human Human DTXSID7046594 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046594 TK.Half.Life NA 5.267 hours 1compartment NA NA Human Human -DTXSID7046594 Css NA 1.744 mg/L 3compartmentss NA 50% Human Human -DTXSID7046594 Css NA 7.654 mg/L 3compartmentss NA 95% Human Human -DTXSID7046594 Css NA 1.203 mg/L PBTK NA 50% Human Human -DTXSID7046594 Css NA 4.734 mg/L PBTK NA 95% Human Human -DTXSID7046594 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046594 Fup NA 0.4505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046594 Vd NA 0.3774 L/kg 1compartment NA NA Rat Human +DTXSID7046594 TK.Half.Life NA 3.968 hours 1compartment NA NA Human Human +DTXSID7046594 Css NA 0.736 mg/L 3compartmentss NA 50% Human Human +DTXSID7046594 Css NA 4.731 mg/L 3compartmentss NA 95% Human Human +DTXSID7046594 Css NA 0.5188 mg/L PBTK NA 50% Human Human +DTXSID7046594 Css NA 2.862 mg/L PBTK NA 95% Human Human +DTXSID7046594 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046594 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046594 Vd NA 0.4041 L/kg 1compartment NA NA Rat Human DTXSID7046594 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046594 TK.Half.Life NA 1.847 hours 1compartment NA NA Rat Human -DTXSID7046594 Css NA 0.4762 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046594 Css NA 1.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046594 Css NA 0.3117 mg/L PBTK NA 50% Rat Human -DTXSID7046594 Css NA 1.05 mg/L PBTK NA 95% Rat Human -DTXSID7046621 Clint NA 362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046621 Fup NA 0.0242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046621 Vd NA 0.5168 L/kg 1compartment NA NA Human Human -DTXSID7046621 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046621 TK.Half.Life NA 0.7028 hours 1compartment NA NA Human Human -DTXSID7046621 Css NA 0.07841 mg/L 3compartmentss NA 50% Human Human -DTXSID7046621 Css NA 0.8018 mg/L 3compartmentss NA 95% Human Human -DTXSID7046621 Css NA 0.0473 mg/L PBTK NA 50% Human Human -DTXSID7046621 Css NA 0.4755 mg/L PBTK NA 95% Human Human -DTXSID7046621 Clint NA 362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046621 Fup NA 0.0242 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046621 Vd NA 0.4048 L/kg 1compartment NA NA Rat Human +DTXSID7046594 TK.Half.Life NA 1.423 hours 1compartment NA NA Rat Human +DTXSID7046594 Css NA 0.003892 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046594 Css NA 0.02638 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046594 Css NA 0.002624 mg/L PBTK NA 50% Rat Human +DTXSID7046594 Css NA 0.01527 mg/L PBTK NA 95% Rat Human +DTXSID7046621 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046621 Fup 0.0381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046621 Vd NA 2.075 L/kg 1compartment NA NA Human Human +DTXSID7046621 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7046621 TK.Half.Life NA 14.05 hours 1compartment NA NA Human Human +DTXSID7046621 Css NA 0.8091 mg/L 3compartmentss NA 50% Human Human +DTXSID7046621 Css NA 6.478 mg/L 3compartmentss NA 95% Human Human +DTXSID7046621 Css NA 0.5327 mg/L PBTK NA 50% Human Human +DTXSID7046621 Css NA 4.061 mg/L PBTK NA 95% Human Human +DTXSID7046621 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046621 Fup 0.0381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046621 Vd NA 1.55 L/kg 1compartment NA NA Rat Human DTXSID7046621 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046621 TK.Half.Life NA 0.2812 hours 1compartment NA NA Rat Human -DTXSID7046621 Css NA 0.04528 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046621 Css NA 0.3938 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046621 Css NA 0.0254 mg/L PBTK NA 50% Rat Human -DTXSID7046621 Css NA 0.2165 mg/L PBTK NA 95% Rat Human -DTXSID7046623 Clint NA 0.3098 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046623 Fup NA 0.1957 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046623 Vd NA 0.2835 L/kg 1compartment NA NA Human Human -DTXSID7046623 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046623 TK.Half.Life NA 6.217 hours 1compartment NA NA Human Human -DTXSID7046623 Css NA 2.715 mg/L 3compartmentss NA 50% Human Human -DTXSID7046623 Css NA 10.29 mg/L 3compartmentss NA 95% Human Human -DTXSID7046623 Css NA 1.734 mg/L PBTK NA 50% Human Human -DTXSID7046623 Css NA 6.216 mg/L PBTK NA 95% Human Human -DTXSID7046623 Clint NA 0.3098 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046623 Fup NA 0.1957 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046623 Vd NA 0.2855 L/kg 1compartment NA NA Rat Human +DTXSID7046621 TK.Half.Life NA 4.404 hours 1compartment NA NA Rat Human +DTXSID7046621 Css NA 0.04094 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046621 Css NA 0.3475 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046621 Css NA 0.02626 mg/L PBTK NA 50% Rat Human +DTXSID7046621 Css NA 0.2089 mg/L PBTK NA 95% Rat Human +DTXSID7046623 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046623 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046623 Vd NA 0.872 L/kg 1compartment NA NA Human Human +DTXSID7046623 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7046623 TK.Half.Life NA 13.67 hours 1compartment NA NA Human Human +DTXSID7046623 Css NA 1.616 mg/L 3compartmentss NA 50% Human Human +DTXSID7046623 Css NA 7.728 mg/L 3compartmentss NA 95% Human Human +DTXSID7046623 Css NA 1.267 mg/L PBTK NA 50% Human Human +DTXSID7046623 Css NA 4.947 mg/L PBTK NA 95% Human Human +DTXSID7046623 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046623 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046623 Vd NA 0.8096 L/kg 1compartment NA NA Rat Human DTXSID7046623 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046623 TK.Half.Life NA 2.579 hours 1compartment NA NA Rat Human -DTXSID7046623 Css NA 0.9502 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046623 Css NA 2.954 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046623 Css NA 0.5691 mg/L PBTK NA 50% Rat Human -DTXSID7046623 Css NA 1.655 mg/L PBTK NA 95% Rat Human +DTXSID7046623 TK.Half.Life NA 4.216 hours 1compartment NA NA Rat Human +DTXSID7046623 Css NA 0.1032 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046623 Css NA 0.4123 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046623 Css NA 0.08003 mg/L PBTK NA 50% Rat Human +DTXSID7046623 Css NA 0.2585 mg/L PBTK NA 95% Rat Human DTXSID7046627 Clint 2.336 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID7046627 Fup 0.02 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID7046627 Vd NA 0.6602 L/kg 1compartment NA NA Human Human -DTXSID7046627 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID7046627 TK.Half.Life NA 41.46 hours 1compartment NA NA Human Human -DTXSID7046627 Css NA 5.438 mg/L 3compartmentss NA 50% Human Human -DTXSID7046627 Css NA 44.16 mg/L 3compartmentss NA 95% Human Human -DTXSID7046627 Css NA 3.762 mg/L PBTK NA 50% Human Human -DTXSID7046627 Css NA 26.85 mg/L PBTK NA 95% Human Human +DTXSID7046627 Vd NA 1.826 L/kg 1compartment NA NA Human Human +DTXSID7046627 Days.Css NA 27 Days PBTK NA NA Human Human +DTXSID7046627 TK.Half.Life NA 134.6 hours 1compartment NA NA Human Human +DTXSID7046627 Css NA 10.56 mg/L 3compartmentss NA 50% Human Human +DTXSID7046627 Css NA 63.61 mg/L 3compartmentss NA 95% Human Human +DTXSID7046627 Css NA 7.474 mg/L PBTK NA 50% Human Human +DTXSID7046627 Css NA 45.02 mg/L PBTK NA 95% Human Human DTXSID7046627 Clint 9.375 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID7046627 Fup 0.016 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID7046627 Vd NA 0.4516 L/kg 1compartment NA NA Rat Rat -DTXSID7046627 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID7046627 TK.Half.Life NA 6.484 hours 1compartment NA NA Rat Rat -DTXSID7046627 Css NA 1.976 mg/L 3compartmentss NA 50% Rat Rat -DTXSID7046627 Css NA 14.56 mg/L 3compartmentss NA 95% Rat Rat -DTXSID7046627 Css NA 1.284 mg/L PBTK NA 50% Rat Rat -DTXSID7046627 Css NA 8.361 mg/L PBTK NA 95% Rat Rat -DTXSID7046673 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7046627 Vd 2.4 1.242 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID7046627 Days.Css NA 2 Days PBTK NA NA Rat Rat +DTXSID7046627 TK.Half.Life 0.12 14.33 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID7046627 Css 0.003 0.4083 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID7046627 Css 0.003 2.51 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID7046627 Css 0.003 0.2992 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID7046627 Css 0.003 1.84 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID7046673 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7046673 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7046673 Vd NA 1.149 L/kg 1compartment NA NA Human Human -DTXSID7046673 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7046673 TK.Half.Life NA 10.44 hours 1compartment NA NA Human Human -DTXSID7046673 Css NA 0.988 mg/L 3compartmentss NA 50% Human Human -DTXSID7046673 Css NA 6.143 mg/L 3compartmentss NA 95% Human Human -DTXSID7046673 Css NA 0.8724 mg/L PBTK NA 50% Human Human -DTXSID7046673 Css NA 4.06 mg/L PBTK NA 95% Human Human -DTXSID7046673 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7046673 Vd NA 0.9652 L/kg 1compartment NA NA Human Human +DTXSID7046673 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7046673 TK.Half.Life NA 8.512 hours 1compartment NA NA Human Human +DTXSID7046673 Css NA 0.8396 mg/L 3compartmentss NA 50% Human Human +DTXSID7046673 Css NA 5.633 mg/L 3compartmentss NA 95% Human Human +DTXSID7046673 Css NA 0.7252 mg/L PBTK NA 50% Human Human +DTXSID7046673 Css NA 3.696 mg/L PBTK NA 95% Human Human +DTXSID7046673 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7046673 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7046673 Vd NA 1.075 L/kg 1compartment NA NA Rat Human +DTXSID7046673 Vd NA 0.9386 L/kg 1compartment NA NA Rat Human DTXSID7046673 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046673 TK.Half.Life NA 3.2 hours 1compartment NA NA Rat Human -DTXSID7046673 Css NA 0.2518 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046673 Css NA 1.671 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046673 Css NA 0.2169 mg/L PBTK NA 50% Rat Human -DTXSID7046673 Css NA 1.017 mg/L PBTK NA 95% Rat Human -DTXSID7046675 Clint NA 279.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046675 Fup NA 0.0123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046675 Vd NA 1.883 L/kg 1compartment NA NA Human Human +DTXSID7046673 TK.Half.Life NA 2.775 hours 1compartment NA NA Rat Human +DTXSID7046673 Css NA 0.01594 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046673 Css NA 0.136 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046673 Css NA 0.01324 mg/L PBTK NA 50% Rat Human +DTXSID7046673 Css NA 0.08831 mg/L PBTK NA 95% Rat Human +DTXSID7046675 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046675 Fup 0.0476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046675 Vd NA 1.564 L/kg 1compartment NA NA Human Human DTXSID7046675 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046675 TK.Half.Life NA 2.323 hours 1compartment NA NA Human Human -DTXSID7046675 Css NA 0.06463 mg/L 3compartmentss NA 50% Human Human -DTXSID7046675 Css NA 0.5994 mg/L 3compartmentss NA 95% Human Human -DTXSID7046675 Css NA 0.04271 mg/L PBTK NA 50% Human Human -DTXSID7046675 Css NA 0.3717 mg/L PBTK NA 95% Human Human -DTXSID7046675 Clint NA 279.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046675 Fup NA 0.0123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046675 Vd NA 1.514 L/kg 1compartment NA NA Rat Human +DTXSID7046675 TK.Half.Life NA 5.572 hours 1compartment NA NA Human Human +DTXSID7046675 Css NA 0.3744 mg/L 3compartmentss NA 50% Human Human +DTXSID7046675 Css NA 3.446 mg/L 3compartmentss NA 95% Human Human +DTXSID7046675 Css NA 0.2622 mg/L PBTK NA 50% Human Human +DTXSID7046675 Css NA 2.249 mg/L PBTK NA 95% Human Human +DTXSID7046675 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046675 Fup 0.0476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046675 Vd NA 1.447 L/kg 1compartment NA NA Rat Human DTXSID7046675 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046675 TK.Half.Life NA 0.8723 hours 1compartment NA NA Rat Human -DTXSID7046675 Css NA 0.03685 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046675 Css NA 0.2906 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046675 Css NA 0.0229 mg/L PBTK NA 50% Rat Human -DTXSID7046675 Css NA 0.1709 mg/L PBTK NA 95% Rat Human -DTXSID7046677 Clint NA 45.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046677 Fup NA 0.8982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046677 Vd NA 5.497 L/kg 1compartment NA NA Human Human +DTXSID7046675 TK.Half.Life NA 3.078 hours 1compartment NA NA Rat Human +DTXSID7046675 Css NA 0.018 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046675 Css NA 0.1893 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046675 Css NA 0.01235 mg/L PBTK NA 50% Rat Human +DTXSID7046675 Css NA 0.1165 mg/L PBTK NA 95% Rat Human +DTXSID7046677 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046677 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046677 Vd NA 1.038 L/kg 1compartment NA NA Human Human DTXSID7046677 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046677 TK.Half.Life NA 3.773 hours 1compartment NA NA Human Human -DTXSID7046677 Css NA 0.02033 mg/L 3compartmentss NA 50% Human Human -DTXSID7046677 Css NA 0.1662 mg/L 3compartmentss NA 95% Human Human -DTXSID7046677 Css NA 0.02558 mg/L PBTK NA 50% Human Human -DTXSID7046677 Css NA 0.1727 mg/L PBTK NA 95% Human Human -DTXSID7046677 Clint NA 45.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046677 Fup NA 0.8982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046677 Vd NA 5.093 L/kg 1compartment NA NA Rat Human +DTXSID7046677 TK.Half.Life NA 2.071 hours 1compartment NA NA Human Human +DTXSID7046677 Css NA 0.1749 mg/L 3compartmentss NA 50% Human Human +DTXSID7046677 Css NA 1.559 mg/L 3compartmentss NA 95% Human Human +DTXSID7046677 Css NA 0.1224 mg/L PBTK NA 50% Human Human +DTXSID7046677 Css NA 0.9865 mg/L PBTK NA 95% Human Human +DTXSID7046677 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046677 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046677 Vd NA 1.03 L/kg 1compartment NA NA Rat Human DTXSID7046677 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046677 TK.Half.Life NA 1.264 hours 1compartment NA NA Rat Human -DTXSID7046677 Css NA 0.01065 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046677 Css NA 0.07461 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046677 Css NA 0.01358 mg/L PBTK NA 50% Rat Human -DTXSID7046677 Css NA 0.08014 mg/L PBTK NA 95% Rat Human -DTXSID7046700 Clint NA 170.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046700 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046700 Vd NA 421.8 L/kg 1compartment NA NA Human Human -DTXSID7046700 Days.Css NA 139 Days PBTK NA NA Human Human -DTXSID7046700 TK.Half.Life NA 620.5 hours 1compartment NA NA Human Human -DTXSID7046700 Css NA 0.00225 mg/L 3compartmentss NA 50% Human Human -DTXSID7046700 Css NA 0.02039 mg/L 3compartmentss NA 95% Human Human -DTXSID7046700 Css NA 0.1323 mg/L PBTK NA 50% Human Human -DTXSID7046700 Css NA 0.8093 mg/L PBTK NA 95% Human Human -DTXSID7046700 Clint NA 170.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046700 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046700 Vd NA 379.6 L/kg 1compartment NA NA Rat Human -DTXSID7046700 Days.Css NA 99 Days PBTK NA NA Rat Human -DTXSID7046700 TK.Half.Life NA 111.3 hours 1compartment NA NA Rat Human -DTXSID7046700 Css NA 0.0011 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046700 Css NA 0.008479 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046700 Css NA 0.0715 mg/L PBTK NA 50% Rat Human -DTXSID7046700 Css NA 0.3645 mg/L PBTK NA 95% Rat Human -DTXSID7046702 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046702 Fup NA 0.2424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046702 Vd NA 0.3444 L/kg 1compartment NA NA Human Human -DTXSID7046702 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046702 TK.Half.Life NA 9.199 hours 1compartment NA NA Human Human -DTXSID7046702 Css NA 3.342 mg/L 3compartmentss NA 50% Human Human -DTXSID7046702 Css NA 12.53 mg/L 3compartmentss NA 95% Human Human -DTXSID7046702 Css NA 2.182 mg/L PBTK NA 50% Human Human -DTXSID7046702 Css NA 7.601 mg/L PBTK NA 95% Human Human -DTXSID7046702 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046702 Fup NA 0.2424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046702 Vd NA 0.3478 L/kg 1compartment NA NA Rat Human +DTXSID7046677 TK.Half.Life NA 1.196 hours 1compartment NA NA Rat Human +DTXSID7046677 Css NA 0.02267 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046677 Css NA 0.1515 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046677 Css NA 0.01556 mg/L PBTK NA 50% Rat Human +DTXSID7046677 Css NA 0.09242 mg/L PBTK NA 95% Rat Human +DTXSID7046700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046700 Fup 0.0282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046700 Vd NA 47.67 L/kg 1compartment NA NA Human Human +DTXSID7046700 Days.Css NA 117 Days PBTK NA NA Human Human +DTXSID7046700 TK.Half.Life NA 527.1 hours 1compartment NA NA Human Human +DTXSID7046700 Css NA 0.09767 mg/L 3compartmentss NA 50% Human Human +DTXSID7046700 Css NA 0.8684 mg/L 3compartmentss NA 95% Human Human +DTXSID7046700 Css NA 0.506 mg/L PBTK NA 50% Human Human +DTXSID7046700 Css NA 3.428 mg/L PBTK NA 95% Human Human +DTXSID7046700 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046700 Fup 0.0282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046700 Vd NA 40.11 L/kg 1compartment NA NA Rat Human +DTXSID7046700 Days.Css NA 76 Days PBTK NA NA Rat Human +DTXSID7046700 TK.Half.Life NA 78.3 hours 1compartment NA NA Rat Human +DTXSID7046700 Css NA 0.000944 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046700 Css NA 0.007506 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046700 Css NA 0.005248 mg/L PBTK NA 50% Rat Human +DTXSID7046700 Css NA 0.03309 mg/L PBTK NA 95% Rat Human +DTXSID7046702 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046702 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046702 Vd NA 0.3219 L/kg 1compartment NA NA Human Human +DTXSID7046702 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7046702 TK.Half.Life NA 9.921 hours 1compartment NA NA Human Human +DTXSID7046702 Css NA 2.065 mg/L 3compartmentss NA 50% Human Human +DTXSID7046702 Css NA 8.207 mg/L 3compartmentss NA 95% Human Human +DTXSID7046702 Css NA 1.334 mg/L PBTK NA 50% Human Human +DTXSID7046702 Css NA 4.948 mg/L PBTK NA 95% Human Human +DTXSID7046702 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046702 Fup 0.21 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046702 Vd NA 0.3249 L/kg 1compartment NA NA Rat Human DTXSID7046702 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046702 TK.Half.Life NA 3.164 hours 1compartment NA NA Rat Human -DTXSID7046702 Css NA 0.9295 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046702 Css NA 2.779 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046702 Css NA 0.5735 mg/L PBTK NA 50% Rat Human -DTXSID7046702 Css NA 1.579 mg/L PBTK NA 95% Rat Human +DTXSID7046702 TK.Half.Life NA 3.411 hours 1compartment NA NA Rat Human +DTXSID7046702 Css NA 0.01136 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046702 Css NA 0.0429 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046702 Css NA 0.006939 mg/L PBTK NA 50% Rat Human +DTXSID7046702 Css NA 0.02471 mg/L PBTK NA 95% Rat Human DTXSID7046706 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7046706 Fup NA 0.8131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046706 Vd NA 0.5911 L/kg 1compartment NA NA Human Human +DTXSID7046706 Vd NA 0.5828 L/kg 1compartment NA NA Human Human DTXSID7046706 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046706 TK.Half.Life NA 4.702 hours 1compartment NA NA Human Human -DTXSID7046706 Css NA 1.024 mg/L 3compartmentss NA 50% Human Human -DTXSID7046706 Css NA 5.943 mg/L 3compartmentss NA 95% Human Human -DTXSID7046706 Css NA 0.8098 mg/L PBTK NA 50% Human Human -DTXSID7046706 Css NA 3.742 mg/L PBTK NA 95% Human Human +DTXSID7046706 TK.Half.Life NA 4.636 hours 1compartment NA NA Human Human +DTXSID7046706 Css NA 0.8679 mg/L 3compartmentss NA 50% Human Human +DTXSID7046706 Css NA 5.138 mg/L 3compartmentss NA 95% Human Human +DTXSID7046706 Css NA 0.6865 mg/L PBTK NA 50% Human Human +DTXSID7046706 Css NA 3.209 mg/L PBTK NA 95% Human Human DTXSID7046706 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7046706 Fup NA 0.8131 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046706 Vd NA 0.6366 L/kg 1compartment NA NA Rat Human +DTXSID7046706 Vd NA 0.6299 L/kg 1compartment NA NA Rat Human DTXSID7046706 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046706 TK.Half.Life NA 1.726 hours 1compartment NA NA Rat Human -DTXSID7046706 Css NA 0.2616 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046706 Css NA 1.512 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046706 Css NA 0.2 mg/L PBTK NA 50% Rat Human -DTXSID7046706 Css NA 0.8925 mg/L PBTK NA 95% Rat Human +DTXSID7046706 TK.Half.Life NA 1.708 hours 1compartment NA NA Rat Human +DTXSID7046706 Css NA 0.01641 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046706 Css NA 0.1209 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046706 Css NA 0.0124 mg/L PBTK NA 50% Rat Human +DTXSID7046706 Css NA 0.07676 mg/L PBTK NA 95% Rat Human DTXSID7046708 Clint NA 1189 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7046708 Fup NA 0.0529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046708 Vd NA 0.7323 L/kg 1compartment NA NA Human Human +DTXSID7046708 Vd NA 0.9325 L/kg 1compartment NA NA Human Human DTXSID7046708 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046708 TK.Half.Life NA 0.7131 hours 1compartment NA NA Human Human -DTXSID7046708 Css NA 0.01101 mg/L 3compartmentss NA 50% Human Human -DTXSID7046708 Css NA 0.09129 mg/L 3compartmentss NA 95% Human Human -DTXSID7046708 Css NA 0.006749 mg/L PBTK NA 50% Human Human -DTXSID7046708 Css NA 0.05399 mg/L PBTK NA 95% Human Human +DTXSID7046708 TK.Half.Life NA 0.8987 hours 1compartment NA NA Human Human +DTXSID7046708 Css NA 0.005378 mg/L 3compartmentss NA 50% Human Human +DTXSID7046708 Css NA 0.07388 mg/L 3compartmentss NA 95% Human Human +DTXSID7046708 Css NA 0.003378 mg/L PBTK NA 50% Human Human +DTXSID7046708 Css NA 0.04512 mg/L PBTK NA 95% Human Human DTXSID7046708 Clint NA 1189 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7046708 Fup NA 0.0529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046708 Vd NA 0.5731 L/kg 1compartment NA NA Rat Human +DTXSID7046708 Vd NA 0.7153 L/kg 1compartment NA NA Rat Human DTXSID7046708 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046708 TK.Half.Life NA 0.2519 hours 1compartment NA NA Rat Human -DTXSID7046708 Css NA 0.006197 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046708 Css NA 0.04537 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046708 Css NA 0.003583 mg/L PBTK NA 50% Rat Human -DTXSID7046708 Css NA 0.02508 mg/L PBTK NA 95% Rat Human -DTXSID7046750 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046750 Fup NA 0.4297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046750 Vd NA 0.411 L/kg 1compartment NA NA Human Human -DTXSID7046750 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046750 TK.Half.Life NA 6.189 hours 1compartment NA NA Human Human -DTXSID7046750 Css NA 1.761 mg/L 3compartmentss NA 50% Human Human -DTXSID7046750 Css NA 7.853 mg/L 3compartmentss NA 95% Human Human -DTXSID7046750 Css NA 1.254 mg/L PBTK NA 50% Human Human -DTXSID7046750 Css NA 4.888 mg/L PBTK NA 95% Human Human -DTXSID7046750 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046750 Fup NA 0.4297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046750 Vd NA 0.4446 L/kg 1compartment NA NA Rat Human -DTXSID7046750 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046750 TK.Half.Life NA 2.281 hours 1compartment NA NA Rat Human -DTXSID7046750 Css NA 0.4823 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046750 Css NA 1.817 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046750 Css NA 0.3258 mg/L PBTK NA 50% Rat Human -DTXSID7046750 Css NA 1.057 mg/L PBTK NA 95% Rat Human -DTXSID7046752 Clint NA 5.236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046752 Fup NA 0.0918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046752 Vd NA 0.6836 L/kg 1compartment NA NA Human Human -DTXSID7046752 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046752 TK.Half.Life NA 5.449 hours 1compartment NA NA Human Human -DTXSID7046752 Css NA 1.204 mg/L 3compartmentss NA 50% Human Human -DTXSID7046752 Css NA 7.881 mg/L 3compartmentss NA 95% Human Human -DTXSID7046752 Css NA 0.7574 mg/L PBTK NA 50% Human Human -DTXSID7046752 Css NA 4.755 mg/L PBTK NA 95% Human Human -DTXSID7046752 Clint NA 5.236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046752 Fup NA 0.0918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046752 Vd NA 0.5639 L/kg 1compartment NA NA Rat Human -DTXSID7046752 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046752 TK.Half.Life NA 2.649 hours 1compartment NA NA Rat Human -DTXSID7046752 Css NA 0.6224 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046752 Css NA 3.219 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046752 Css NA 0.3709 mg/L PBTK NA 50% Rat Human -DTXSID7046752 Css NA 1.799 mg/L PBTK NA 95% Rat Human -DTXSID7046754 Clint NA 118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046754 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046754 Vd NA 127.4 L/kg 1compartment NA NA Human Human -DTXSID7046754 Days.Css NA 160 Days PBTK NA NA Human Human -DTXSID7046754 TK.Half.Life NA 695.9 hours 1compartment NA NA Human Human -DTXSID7046754 Css NA 0.02812 mg/L 3compartmentss NA 50% Human Human -DTXSID7046754 Css NA 0.1773 mg/L 3compartmentss NA 95% Human Human -DTXSID7046754 Css NA 0.4496 mg/L PBTK NA 50% Human Human -DTXSID7046754 Css NA 2.561 mg/L PBTK NA 95% Human Human -DTXSID7046754 Clint NA 118 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046754 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046754 Vd NA 111.1 L/kg 1compartment NA NA Rat Human -DTXSID7046754 Days.Css NA 107 Days PBTK NA NA Rat Human -DTXSID7046754 TK.Half.Life NA 106.4 hours 1compartment NA NA Rat Human -DTXSID7046754 Css NA 0.01443 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046754 Css NA 0.0615 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046754 Css NA 0.243 mg/L PBTK NA 50% Rat Human -DTXSID7046754 Css NA 1.057 mg/L PBTK NA 95% Rat Human -DTXSID7046756 Clint NA 51.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046756 Fup NA 0.1294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046756 Vd NA 1.242 L/kg 1compartment NA NA Human Human -DTXSID7046756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046756 TK.Half.Life NA 1.815 hours 1compartment NA NA Human Human -DTXSID7046756 Css NA 0.09864 mg/L 3compartmentss NA 50% Human Human -DTXSID7046756 Css NA 0.8044 mg/L 3compartmentss NA 95% Human Human -DTXSID7046756 Css NA 0.0654 mg/L PBTK NA 50% Human Human -DTXSID7046756 Css NA 0.5014 mg/L PBTK NA 95% Human Human -DTXSID7046756 Clint NA 51.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046756 Fup NA 0.1294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046756 Vd NA 0.9632 L/kg 1compartment NA NA Rat Human +DTXSID7046708 TK.Half.Life NA 0.3103 hours 1compartment NA NA Rat Human +DTXSID7046708 Css NA 0.0001927 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046708 Css NA 0.003322 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046708 Css NA 0.000115 mg/L PBTK NA 50% Rat Human +DTXSID7046708 Css NA 0.001913 mg/L PBTK NA 95% Rat Human +DTXSID7046752 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046752 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046752 Vd NA 2.263 L/kg 1compartment NA NA Human Human +DTXSID7046752 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7046752 TK.Half.Life NA 22.07 hours 1compartment NA NA Human Human +DTXSID7046752 Css NA 1.244 mg/L 3compartmentss NA 50% Human Human +DTXSID7046752 Css NA 7.26 mg/L 3compartmentss NA 95% Human Human +DTXSID7046752 Css NA 0.8544 mg/L PBTK NA 50% Human Human +DTXSID7046752 Css NA 4.75 mg/L PBTK NA 95% Human Human +DTXSID7046752 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046752 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046752 Vd NA 1.715 L/kg 1compartment NA NA Rat Human +DTXSID7046752 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7046752 TK.Half.Life NA 6.256 hours 1compartment NA NA Rat Human +DTXSID7046752 Css NA 0.1524 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046752 Css NA 0.6619 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046752 Css NA 0.1032 mg/L PBTK NA 50% Rat Human +DTXSID7046752 Css NA 0.4219 mg/L PBTK NA 95% Rat Human +DTXSID7046754 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046754 Fup 0.0178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046754 Vd NA 7.577 L/kg 1compartment NA NA Human Human +DTXSID7046754 Days.Css NA 44 Days PBTK NA NA Human Human +DTXSID7046754 TK.Half.Life NA 226.9 hours 1compartment NA NA Human Human +DTXSID7046754 Css NA 2.388 mg/L 3compartmentss NA 50% Human Human +DTXSID7046754 Css NA 14.09 mg/L 3compartmentss NA 95% Human Human +DTXSID7046754 Css NA 2.393 mg/L PBTK NA 50% Human Human +DTXSID7046754 Css NA 13.63 mg/L PBTK NA 95% Human Human +DTXSID7046754 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046754 Fup 0.0178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046754 Vd NA 5.893 L/kg 1compartment NA NA Rat Human +DTXSID7046754 Days.Css NA 26 Days PBTK NA NA Rat Human +DTXSID7046754 TK.Half.Life NA 31.08 hours 1compartment NA NA Rat Human +DTXSID7046754 Css NA 0.3024 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046754 Css NA 1.425 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046754 Css NA 0.3077 mg/L PBTK NA 50% Rat Human +DTXSID7046754 Css NA 1.522 mg/L PBTK NA 95% Rat Human +DTXSID7046756 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046756 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046756 Vd NA 0.721 L/kg 1compartment NA NA Human Human +DTXSID7046756 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7046756 TK.Half.Life NA 13.81 hours 1compartment NA NA Human Human +DTXSID7046756 Css NA 2.103 mg/L 3compartmentss NA 50% Human Human +DTXSID7046756 Css NA 8.526 mg/L 3compartmentss NA 95% Human Human +DTXSID7046756 Css NA 1.532 mg/L PBTK NA 50% Human Human +DTXSID7046756 Css NA 5.408 mg/L PBTK NA 95% Human Human +DTXSID7046756 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046756 Fup 0.349 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046756 Vd NA 0.6517 L/kg 1compartment NA NA Rat Human DTXSID7046756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046756 TK.Half.Life NA 0.7031 hours 1compartment NA NA Rat Human -DTXSID7046756 Css NA 0.05564 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046756 Css NA 0.3436 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046756 Css NA 0.03505 mg/L PBTK NA 50% Rat Human -DTXSID7046756 Css NA 0.2073 mg/L PBTK NA 95% Rat Human -DTXSID7046758 Clint NA 6.562 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046758 Fup NA 0.4812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046758 Vd NA 2.483 L/kg 1compartment NA NA Human Human +DTXSID7046756 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human +DTXSID7046756 Css NA 0.1342 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046756 Css NA 0.4739 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046756 Css NA 0.09666 mg/L PBTK NA 50% Rat Human +DTXSID7046756 Css NA 0.2905 mg/L PBTK NA 95% Rat Human +DTXSID7046758 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046758 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046758 Vd NA 2.08 L/kg 1compartment NA NA Human Human DTXSID7046758 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046758 TK.Half.Life NA 7.289 hours 1compartment NA NA Human Human -DTXSID7046758 Css NA 0.2633 mg/L 3compartmentss NA 50% Human Human -DTXSID7046758 Css NA 1.573 mg/L 3compartmentss NA 95% Human Human -DTXSID7046758 Css NA 0.2118 mg/L PBTK NA 50% Human Human -DTXSID7046758 Css NA 1.156 mg/L PBTK NA 95% Human Human -DTXSID7046758 Clint NA 6.562 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046758 Fup NA 0.4812 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046758 Vd NA 1.951 L/kg 1compartment NA NA Rat Human +DTXSID7046758 TK.Half.Life NA 7.768 hours 1compartment NA NA Human Human +DTXSID7046758 Css NA 0.3496 mg/L 3compartmentss NA 50% Human Human +DTXSID7046758 Css NA 2.04 mg/L 3compartmentss NA 95% Human Human +DTXSID7046758 Css NA 0.266 mg/L PBTK NA 50% Human Human +DTXSID7046758 Css NA 1.432 mg/L PBTK NA 95% Human Human +DTXSID7046758 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046758 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046758 Vd NA 1.627 L/kg 1compartment NA NA Rat Human DTXSID7046758 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046758 TK.Half.Life NA 2.089 hours 1compartment NA NA Rat Human -DTXSID7046758 Css NA 0.1335 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046758 Css NA 0.5807 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046758 Css NA 0.1048 mg/L PBTK NA 50% Rat Human -DTXSID7046758 Css NA 0.3935 mg/L PBTK NA 95% Rat Human +DTXSID7046758 TK.Half.Life NA 2.561 hours 1compartment NA NA Rat Human +DTXSID7046758 Css NA 0.04146 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046758 Css NA 0.1713 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046758 Css NA 0.03152 mg/L PBTK NA 50% Rat Human +DTXSID7046758 Css NA 0.1173 mg/L PBTK NA 95% Rat Human DTXSID7046831 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7046831 Fup NA 0.6768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046831 Vd NA 0.5837 L/kg 1compartment NA NA Human Human +DTXSID7046831 Vd NA 0.536 L/kg 1compartment NA NA Human Human DTXSID7046831 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046831 TK.Half.Life NA 5.581 hours 1compartment NA NA Human Human -DTXSID7046831 Css NA 1.148 mg/L 3compartmentss NA 50% Human Human -DTXSID7046831 Css NA 7.122 mg/L 3compartmentss NA 95% Human Human -DTXSID7046831 Css NA 0.8982 mg/L PBTK NA 50% Human Human -DTXSID7046831 Css NA 4.498 mg/L PBTK NA 95% Human Human +DTXSID7046831 TK.Half.Life NA 5.123 hours 1compartment NA NA Human Human +DTXSID7046831 Css NA 0.9935 mg/L 3compartmentss NA 50% Human Human +DTXSID7046831 Css NA 6.397 mg/L 3compartmentss NA 95% Human Human +DTXSID7046831 Css NA 0.7662 mg/L PBTK NA 50% Human Human +DTXSID7046831 Css NA 3.997 mg/L PBTK NA 95% Human Human DTXSID7046831 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7046831 Fup NA 0.6768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046831 Vd NA 0.6167 L/kg 1compartment NA NA Rat Human +DTXSID7046831 Vd NA 0.5768 L/kg 1compartment NA NA Rat Human DTXSID7046831 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046831 TK.Half.Life NA 2.009 hours 1compartment NA NA Rat Human -DTXSID7046831 Css NA 0.3008 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046831 Css NA 1.817 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046831 Css NA 0.2265 mg/L PBTK NA 50% Rat Human -DTXSID7046831 Css NA 1.064 mg/L PBTK NA 95% Rat Human -DTXSID7046835 Clint NA 12.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046835 Fup NA 0.0489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046835 Vd NA 3.217 L/kg 1compartment NA NA Human Human +DTXSID7046831 TK.Half.Life NA 1.879 hours 1compartment NA NA Rat Human +DTXSID7046831 Css NA 0.01894 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046831 Css NA 0.1543 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046831 Css NA 0.01405 mg/L PBTK NA 50% Rat Human +DTXSID7046831 Css NA 0.09555 mg/L PBTK NA 95% Rat Human +DTXSID7046833 Clint 7.209 NA uL/min/million hepatocytes NA Pradeep 2020 NA Human Human +DTXSID7046833 Fup 0.1582 NA NA Pradeep 2020 NA Human Human +DTXSID7046833 Vd NA 2.927 L/kg 1compartment NA NA Human Human +DTXSID7046833 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7046833 TK.Half.Life NA 45.22 hours 1compartment NA NA Human Human +DTXSID7046833 Css NA 1.56 mg/L 3compartmentss NA 50% Human Human +DTXSID7046833 Css NA 8.878 mg/L 3compartmentss NA 95% Human Human +DTXSID7046833 Css NA 1.1 mg/L PBTK NA 50% Human Human +DTXSID7046833 Css NA 6.029 mg/L PBTK NA 95% Human Human +DTXSID7046833 Clint 7.209 NA uL/min/million hepatocytes NA Pradeep 2020 NA Rat Human +DTXSID7046833 Fup 0.1582 NA NA Pradeep 2020 NA Rat Human +DTXSID7046833 Vd NA 2.206 L/kg 1compartment NA NA Rat Human +DTXSID7046833 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7046833 TK.Half.Life NA 7.85 hours 1compartment NA NA Rat Human +DTXSID7046833 Css NA 0.05628 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046833 Css NA 0.348 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046833 Css NA 0.03849 mg/L PBTK NA 50% Rat Human +DTXSID7046833 Css NA 0.2299 mg/L PBTK NA 95% Rat Human +DTXSID7046835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046835 Fup 0.0647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046835 Vd NA 3.632 L/kg 1compartment NA NA Human Human DTXSID7046835 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046835 TK.Half.Life NA 4.847 hours 1compartment NA NA Human Human -DTXSID7046835 Css NA 0.1114 mg/L 3compartmentss NA 50% Human Human -DTXSID7046835 Css NA 1.035 mg/L 3compartmentss NA 95% Human Human -DTXSID7046835 Css NA 0.09847 mg/L PBTK NA 50% Human Human -DTXSID7046835 Css NA 0.7859 mg/L PBTK NA 95% Human Human -DTXSID7046835 Clint NA 12.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046835 Fup NA 0.0489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046835 Vd NA 2.938 L/kg 1compartment NA NA Rat Human +DTXSID7046835 TK.Half.Life NA 3.606 hours 1compartment NA NA Human Human +DTXSID7046835 Css NA 0.04507 mg/L 3compartmentss NA 50% Human Human +DTXSID7046835 Css NA 0.4093 mg/L 3compartmentss NA 95% Human Human +DTXSID7046835 Css NA 0.0425 mg/L PBTK NA 50% Human Human +DTXSID7046835 Css NA 0.3294 mg/L PBTK NA 95% Human Human +DTXSID7046835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046835 Fup 0.0647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046835 Vd NA 3.329 L/kg 1compartment NA NA Rat Human DTXSID7046835 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046835 TK.Half.Life NA 2.137 hours 1compartment NA NA Rat Human -DTXSID7046835 Css NA 0.06122 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046835 Css NA 0.4643 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046835 Css NA 0.05236 mg/L PBTK NA 50% Rat Human -DTXSID7046835 Css NA 0.331 mg/L PBTK NA 95% Rat Human -DTXSID7046837 Clint NA 100.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046837 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046837 Vd NA 6.887 L/kg 1compartment NA NA Human Human +DTXSID7046835 TK.Half.Life NA 1.505 hours 1compartment NA NA Rat Human +DTXSID7046835 Css NA 0.005742 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046835 Css NA 0.04283 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046835 Css NA 0.005547 mg/L PBTK NA 50% Rat Human +DTXSID7046835 Css NA 0.03572 mg/L PBTK NA 95% Rat Human +DTXSID7046837 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046837 Fup 0.0909 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046837 Vd NA 2.261 L/kg 1compartment NA NA Human Human DTXSID7046837 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046837 TK.Half.Life NA 3.471 hours 1compartment NA NA Human Human -DTXSID7046837 Css NA 0.006646 mg/L 3compartmentss NA 50% Human Human -DTXSID7046837 Css NA 0.09191 mg/L 3compartmentss NA 95% Human Human -DTXSID7046837 Css NA 0.007446 mg/L PBTK NA 50% Human Human -DTXSID7046837 Css NA 0.07194 mg/L PBTK NA 95% Human Human -DTXSID7046837 Clint NA 100.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046837 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046837 Vd NA 5.664 L/kg 1compartment NA NA Rat Human +DTXSID7046837 TK.Half.Life NA 2.196 hours 1compartment NA NA Human Human +DTXSID7046837 Css NA 0.04644 mg/L 3compartmentss NA 50% Human Human +DTXSID7046837 Css NA 0.4627 mg/L 3compartmentss NA 95% Human Human +DTXSID7046837 Css NA 0.04306 mg/L PBTK NA 50% Human Human +DTXSID7046837 Css NA 0.3585 mg/L PBTK NA 95% Human Human +DTXSID7046837 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046837 Fup 0.0909 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046837 Vd NA 2.198 L/kg 1compartment NA NA Rat Human DTXSID7046837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046837 TK.Half.Life NA 1.329 hours 1compartment NA NA Rat Human -DTXSID7046837 Css NA 0.003574 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046837 Css NA 0.04599 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046837 Css NA 0.003962 mg/L PBTK NA 50% Rat Human -DTXSID7046837 Css NA 0.03371 mg/L PBTK NA 95% Rat Human -DTXSID7046839 Clint NA 1.998 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046839 Fup NA 0.5854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046839 Vd NA 1.23 L/kg 1compartment NA NA Human Human +DTXSID7046837 TK.Half.Life NA 1.157 hours 1compartment NA NA Rat Human +DTXSID7046837 Css NA 0.006094 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046837 Css NA 0.05221 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046837 Css NA 0.005697 mg/L PBTK NA 50% Rat Human +DTXSID7046837 Css NA 0.03874 mg/L PBTK NA 95% Rat Human +DTXSID7046839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046839 Fup 0.519 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046839 Vd NA 1.148 L/kg 1compartment NA NA Human Human DTXSID7046839 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046839 TK.Half.Life NA 3.84 hours 1compartment NA NA Human Human -DTXSID7046839 Css NA 0.2975 mg/L 3compartmentss NA 50% Human Human -DTXSID7046839 Css NA 2.22 mg/L 3compartmentss NA 95% Human Human -DTXSID7046839 Css NA 0.2537 mg/L PBTK NA 50% Human Human -DTXSID7046839 Css NA 1.515 mg/L PBTK NA 95% Human Human -DTXSID7046839 Clint NA 1.998 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046839 Fup NA 0.5854 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046839 Vd NA 1.098 L/kg 1compartment NA NA Rat Human +DTXSID7046839 TK.Half.Life NA 1.105 hours 1compartment NA NA Human Human +DTXSID7046839 Css NA 0.0372 mg/L 3compartmentss NA 50% Human Human +DTXSID7046839 Css NA 0.3425 mg/L 3compartmentss NA 95% Human Human +DTXSID7046839 Css NA 0.03043 mg/L PBTK NA 50% Human Human +DTXSID7046839 Css NA 0.244 mg/L PBTK NA 95% Human Human +DTXSID7046839 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046839 Fup 0.519 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046839 Vd NA 1.023 L/kg 1compartment NA NA Rat Human DTXSID7046839 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046839 TK.Half.Life NA 1.709 hours 1compartment NA NA Rat Human -DTXSID7046839 Css NA 0.1297 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046839 Css NA 0.9076 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046839 Css NA 0.1075 mg/L PBTK NA 50% Rat Human -DTXSID7046839 Css NA 0.5506 mg/L PBTK NA 95% Rat Human -DTXSID7046881 Clint NA 2.457 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046881 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046881 Vd NA 0.2483 L/kg 1compartment NA NA Human Human +DTXSID7046839 TK.Half.Life NA 0.4878 hours 1compartment NA NA Rat Human +DTXSID7046839 Css NA 0.004507 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046839 Css NA 0.03516 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046839 Css NA 0.003766 mg/L PBTK NA 50% Rat Human +DTXSID7046839 Css NA 0.02393 mg/L PBTK NA 95% Rat Human +DTXSID7046881 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046881 Fup 0.0686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046881 Vd NA 0.3339 L/kg 1compartment NA NA Human Human DTXSID7046881 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046881 TK.Half.Life NA 9.369 hours 1compartment NA NA Human Human -DTXSID7046881 Css NA 6.994 mg/L 3compartmentss NA 50% Human Human -DTXSID7046881 Css NA 40.38 mg/L 3compartmentss NA 95% Human Human -DTXSID7046881 Css NA 4.209 mg/L PBTK NA 50% Human Human -DTXSID7046881 Css NA 23.42 mg/L PBTK NA 95% Human Human -DTXSID7046881 Clint NA 2.457 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046881 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046881 Vd NA 0.2434 L/kg 1compartment NA NA Rat Human +DTXSID7046881 TK.Half.Life NA 3.027 hours 1compartment NA NA Human Human +DTXSID7046881 Css NA 1.43 mg/L 3compartmentss NA 50% Human Human +DTXSID7046881 Css NA 9.973 mg/L 3compartmentss NA 95% Human Human +DTXSID7046881 Css NA 0.887 mg/L PBTK NA 50% Human Human +DTXSID7046881 Css NA 5.954 mg/L PBTK NA 95% Human Human +DTXSID7046881 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046881 Fup 0.0686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046881 Vd NA 0.3276 L/kg 1compartment NA NA Rat Human DTXSID7046881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046881 TK.Half.Life NA 5.291 hours 1compartment NA NA Rat Human -DTXSID7046881 Css NA 3.373 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046881 Css NA 14.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046881 Css NA 1.892 mg/L PBTK NA 50% Rat Human -DTXSID7046881 Css NA 7.843 mg/L PBTK NA 95% Rat Human -DTXSID7046883 Clint NA 5.382 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046883 Fup NA 0.2734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046883 Vd NA 2.707 L/kg 1compartment NA NA Human Human -DTXSID7046883 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7046883 TK.Half.Life NA 21.23 hours 1compartment NA NA Human Human -DTXSID7046883 Css NA 0.8555 mg/L 3compartmentss NA 50% Human Human -DTXSID7046883 Css NA 4.346 mg/L 3compartmentss NA 95% Human Human -DTXSID7046883 Css NA 0.6289 mg/L PBTK NA 50% Human Human -DTXSID7046883 Css NA 3.045 mg/L PBTK NA 95% Human Human -DTXSID7046883 Clint NA 5.382 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046883 Fup NA 0.2734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046883 Vd NA 2.064 L/kg 1compartment NA NA Rat Human -DTXSID7046883 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7046883 TK.Half.Life NA 4.655 hours 1compartment NA NA Rat Human -DTXSID7046883 Css NA 0.4374 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046883 Css NA 1.588 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046883 Css NA 0.3095 mg/L PBTK NA 50% Rat Human -DTXSID7046883 Css NA 1.054 mg/L PBTK NA 95% Rat Human -DTXSID7046885 Clint NA 1.041 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046885 Fup NA 0.5856 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046885 Vd NA 0.5955 L/kg 1compartment NA NA Human Human +DTXSID7046881 TK.Half.Life NA 1.839 hours 1compartment NA NA Rat Human +DTXSID7046881 Css NA 0.1757 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046881 Css NA 0.8986 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046881 Css NA 0.1064 mg/L PBTK NA 50% Rat Human +DTXSID7046881 Css NA 0.5201 mg/L PBTK NA 95% Rat Human +DTXSID7046883 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046883 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046883 Vd NA 1.881 L/kg 1compartment NA NA Human Human +DTXSID7046883 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7046883 TK.Half.Life NA 3.164 hours 1compartment NA NA Human Human +DTXSID7046883 Css NA 0.1112 mg/L 3compartmentss NA 50% Human Human +DTXSID7046883 Css NA 0.7566 mg/L 3compartmentss NA 95% Human Human +DTXSID7046883 Css NA 0.08282 mg/L PBTK NA 50% Human Human +DTXSID7046883 Css NA 0.5229 mg/L PBTK NA 95% Human Human +DTXSID7046883 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046883 Fup 0.252 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046883 Vd NA 1.471 L/kg 1compartment NA NA Rat Human +DTXSID7046883 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7046883 TK.Half.Life NA 1.131 hours 1compartment NA NA Rat Human +DTXSID7046883 Css NA 0.01401 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046883 Css NA 0.07161 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046883 Css NA 0.01039 mg/L PBTK NA 50% Rat Human +DTXSID7046883 Css NA 0.0495 mg/L PBTK NA 95% Rat Human +DTXSID7046885 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046885 Fup 0.654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046885 Vd NA 0.6742 L/kg 1compartment NA NA Human Human DTXSID7046885 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046885 TK.Half.Life NA 2.517 hours 1compartment NA NA Human Human -DTXSID7046885 Css NA 0.4604 mg/L 3compartmentss NA 50% Human Human -DTXSID7046885 Css NA 3.307 mg/L 3compartmentss NA 95% Human Human -DTXSID7046885 Css NA 0.3622 mg/L PBTK NA 50% Human Human -DTXSID7046885 Css NA 2.088 mg/L PBTK NA 95% Human Human -DTXSID7046885 Clint NA 1.041 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046885 Fup NA 0.5856 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046885 Vd NA 0.6102 L/kg 1compartment NA NA Rat Human +DTXSID7046885 TK.Half.Life NA 6.671 hours 1compartment NA NA Human Human +DTXSID7046885 Css NA 0.974 mg/L 3compartmentss NA 50% Human Human +DTXSID7046885 Css NA 6.37 mg/L 3compartmentss NA 95% Human Human +DTXSID7046885 Css NA 0.7936 mg/L PBTK NA 50% Human Human +DTXSID7046885 Css NA 4.056 mg/L PBTK NA 95% Human Human +DTXSID7046885 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046885 Fup 0.654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046885 Vd NA 0.6946 L/kg 1compartment NA NA Rat Human DTXSID7046885 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046885 TK.Half.Life NA 1.266 hours 1compartment NA NA Rat Human -DTXSID7046885 Css NA 0.1826 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046885 Css NA 1.211 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046885 Css NA 0.1377 mg/L PBTK NA 50% Rat Human -DTXSID7046885 Css NA 0.7044 mg/L PBTK NA 95% Rat Human -DTXSID7046887 Clint NA 4.202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046887 Fup NA 0.9573 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046887 Vd NA 0.7055 L/kg 1compartment NA NA Human Human +DTXSID7046885 TK.Half.Life NA 2.342 hours 1compartment NA NA Rat Human +DTXSID7046885 Css NA 0.02546 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046885 Css NA 0.1966 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046885 Css NA 0.02043 mg/L PBTK NA 50% Rat Human +DTXSID7046885 Css NA 0.1251 mg/L PBTK NA 95% Rat Human +DTXSID7046887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046887 Fup 0.463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046887 Vd NA 0.4261 L/kg 1compartment NA NA Human Human DTXSID7046887 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046887 TK.Half.Life NA 0.9173 hours 1compartment NA NA Human Human -DTXSID7046887 Css NA 0.122 mg/L 3compartmentss NA 50% Human Human -DTXSID7046887 Css NA 0.8937 mg/L 3compartmentss NA 95% Human Human -DTXSID7046887 Css NA 0.09687 mg/L PBTK NA 50% Human Human -DTXSID7046887 Css NA 0.6044 mg/L PBTK NA 95% Human Human -DTXSID7046887 Clint NA 4.202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046887 Fup NA 0.9573 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046887 Vd NA 0.7379 L/kg 1compartment NA NA Rat Human +DTXSID7046887 TK.Half.Life NA 5.955 hours 1compartment NA NA Human Human +DTXSID7046887 Css NA 1.392 mg/L 3compartmentss NA 50% Human Human +DTXSID7046887 Css NA 6.836 mg/L 3compartmentss NA 95% Human Human +DTXSID7046887 Css NA 0.9975 mg/L PBTK NA 50% Human Human +DTXSID7046887 Css NA 4.263 mg/L PBTK NA 95% Human Human +DTXSID7046887 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046887 Fup 0.463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046887 Vd NA 0.452 L/kg 1compartment NA NA Rat Human DTXSID7046887 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046887 TK.Half.Life NA 0.5005 hours 1compartment NA NA Rat Human -DTXSID7046887 Css NA 0.05542 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046887 Css NA 0.3506 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046887 Css NA 0.04338 mg/L PBTK NA 50% Rat Human -DTXSID7046887 Css NA 0.2188 mg/L PBTK NA 95% Rat Human -DTXSID7046889 Clint NA 20.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046889 Fup NA 0.0378 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046889 Vd NA 0.954 L/kg 1compartment NA NA Human Human +DTXSID7046887 TK.Half.Life NA 2.152 hours 1compartment NA NA Rat Human +DTXSID7046887 Css NA 0.0357 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046887 Css NA 0.224 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046887 Css NA 0.02486 mg/L PBTK NA 50% Rat Human +DTXSID7046887 Css NA 0.1384 mg/L PBTK NA 95% Rat Human +DTXSID7046889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046889 Fup 0.0807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046889 Vd NA 1.187 L/kg 1compartment NA NA Human Human DTXSID7046889 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046889 TK.Half.Life NA 5.357 hours 1compartment NA NA Human Human -DTXSID7046889 Css NA 0.877 mg/L 3compartmentss NA 50% Human Human -DTXSID7046889 Css NA 7.747 mg/L 3compartmentss NA 95% Human Human -DTXSID7046889 Css NA 0.5409 mg/L PBTK NA 50% Human Human -DTXSID7046889 Css NA 4.641 mg/L PBTK NA 95% Human Human -DTXSID7046889 Clint NA 20.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046889 Fup NA 0.0378 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046889 Vd NA 0.7238 L/kg 1compartment NA NA Rat Human +DTXSID7046889 TK.Half.Life NA 3.715 hours 1compartment NA NA Human Human +DTXSID7046889 Css NA 0.3636 mg/L 3compartmentss NA 50% Human Human +DTXSID7046889 Css NA 2.841 mg/L 3compartmentss NA 95% Human Human +DTXSID7046889 Css NA 0.2342 mg/L PBTK NA 50% Human Human +DTXSID7046889 Css NA 1.758 mg/L PBTK NA 95% Human Human +DTXSID7046889 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046889 Fup 0.0807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046889 Vd NA 0.9129 L/kg 1compartment NA NA Rat Human DTXSID7046889 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046889 TK.Half.Life NA 2.378 hours 1compartment NA NA Rat Human -DTXSID7046889 Css NA 0.4903 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046889 Css NA 3.305 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046889 Css NA 0.2836 mg/L PBTK NA 50% Rat Human -DTXSID7046889 Css NA 1.842 mg/L PBTK NA 95% Rat Human -DTXSID7046910 Clint NA 6.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046910 Fup NA 0.0273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046910 Vd NA 0.1886 L/kg 1compartment NA NA Human Human +DTXSID7046889 TK.Half.Life NA 1.555 hours 1compartment NA NA Rat Human +DTXSID7046889 Css NA 0.0475 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046889 Css NA 0.2798 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046889 Css NA 0.02986 mg/L PBTK NA 50% Rat Human +DTXSID7046889 Css NA 0.17 mg/L PBTK NA 95% Rat Human +DTXSID7046910 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046910 Fup 0.0913 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046910 Vd NA 0.2646 L/kg 1compartment NA NA Human Human DTXSID7046910 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046910 TK.Half.Life NA 4.016 hours 1compartment NA NA Human Human -DTXSID7046910 Css NA 3.899 mg/L 3compartmentss NA 50% Human Human -DTXSID7046910 Css NA 32.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7046910 Css NA 2.295 mg/L PBTK NA 50% Human Human -DTXSID7046910 Css NA 18.61 mg/L PBTK NA 95% Human Human -DTXSID7046910 Clint NA 6.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046910 Fup NA 0.0273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046910 Vd NA 0.1863 L/kg 1compartment NA NA Rat Human +DTXSID7046910 TK.Half.Life NA 1.855 hours 1compartment NA NA Human Human +DTXSID7046910 Css NA 0.5703 mg/L 3compartmentss NA 50% Human Human +DTXSID7046910 Css NA 4.01 mg/L 3compartmentss NA 95% Human Human +DTXSID7046910 Css NA 0.3526 mg/L PBTK NA 50% Human Human +DTXSID7046910 Css NA 2.409 mg/L PBTK NA 95% Human Human +DTXSID7046910 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046910 Fup 0.0913 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046910 Vd NA 0.2601 L/kg 1compartment NA NA Rat Human DTXSID7046910 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046910 TK.Half.Life NA 2.509 hours 1compartment NA NA Rat Human -DTXSID7046910 Css NA 2.068 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046910 Css NA 13.68 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046910 Css NA 1.135 mg/L PBTK NA 50% Rat Human -DTXSID7046910 Css NA 7.405 mg/L PBTK NA 95% Rat Human -DTXSID7046912 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046912 Fup NA 0.324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046912 Vd NA 2.208 L/kg 1compartment NA NA Human Human -DTXSID7046912 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID7046912 TK.Half.Life NA 74.48 hours 1compartment NA NA Human Human -DTXSID7046912 Css NA 3.499 mg/L 3compartmentss NA 50% Human Human -DTXSID7046912 Css NA 12.31 mg/L 3compartmentss NA 95% Human Human -DTXSID7046912 Css NA 2.777 mg/L PBTK NA 50% Human Human -DTXSID7046912 Css NA 8.446 mg/L PBTK NA 95% Human Human -DTXSID7046912 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046912 Fup NA 0.324 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046912 Vd NA 1.796 L/kg 1compartment NA NA Rat Human -DTXSID7046912 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7046912 TK.Half.Life NA 14.23 hours 1compartment NA NA Rat Human -DTXSID7046912 Css NA 0.9402 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046912 Css NA 2.82 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046912 Css NA 0.7256 mg/L PBTK NA 50% Rat Human -DTXSID7046912 Css NA 1.788 mg/L PBTK NA 95% Rat Human -DTXSID7046914 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046914 Fup NA 0.1213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046914 Vd NA 0.8618 L/kg 1compartment NA NA Human Human -DTXSID7046914 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID7046914 TK.Half.Life NA 50.59 hours 1compartment NA NA Human Human -DTXSID7046914 Css NA 8.418 mg/L 3compartmentss NA 50% Human Human -DTXSID7046914 Css NA 39.25 mg/L 3compartmentss NA 95% Human Human -DTXSID7046914 Css NA 5.478 mg/L PBTK NA 50% Human Human -DTXSID7046914 Css NA 23.49 mg/L PBTK NA 95% Human Human -DTXSID7046914 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046914 Fup NA 0.1213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046914 Vd NA 0.6879 L/kg 1compartment NA NA Rat Human -DTXSID7046914 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7046914 TK.Half.Life NA 12.81 hours 1compartment NA NA Rat Human -DTXSID7046914 Css NA 2.408 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046914 Css NA 9.021 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046914 Css NA 1.467 mg/L PBTK NA 50% Rat Human -DTXSID7046914 Css NA 5.053 mg/L PBTK NA 95% Rat Human -DTXSID7046966 Clint NA 4.638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046966 Fup NA 0.6233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7046966 Vd NA 1.645 L/kg 1compartment NA NA Human Human +DTXSID7046910 TK.Half.Life NA 1.116 hours 1compartment NA NA Rat Human +DTXSID7046910 Css NA 0.005732 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046910 Css NA 0.03588 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046910 Css NA 0.00331 mg/L PBTK NA 50% Rat Human +DTXSID7046910 Css NA 0.02011 mg/L PBTK NA 95% Rat Human +DTXSID7046912 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046912 Fup 0.439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046912 Vd NA 1.998 L/kg 1compartment NA NA Human Human +DTXSID7046912 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7046912 TK.Half.Life NA 2.228 hours 1compartment NA NA Human Human +DTXSID7046912 Css NA 0.04253 mg/L 3compartmentss NA 50% Human Human +DTXSID7046912 Css NA 0.3624 mg/L 3compartmentss NA 95% Human Human +DTXSID7046912 Css NA 0.03584 mg/L PBTK NA 50% Human Human +DTXSID7046912 Css NA 0.2662 mg/L PBTK NA 95% Human Human +DTXSID7046912 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046912 Fup 0.439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046912 Vd NA 1.697 L/kg 1compartment NA NA Rat Human +DTXSID7046912 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7046912 TK.Half.Life NA 0.8877 hours 1compartment NA NA Rat Human +DTXSID7046912 Css NA 0.001981 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046912 Css NA 0.01901 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046912 Css NA 0.001705 mg/L PBTK NA 50% Rat Human +DTXSID7046912 Css NA 0.01365 mg/L PBTK NA 95% Rat Human +DTXSID7046914 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046914 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046914 Vd NA 0.839 L/kg 1compartment NA NA Human Human +DTXSID7046914 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7046914 TK.Half.Life NA 1.53 hours 1compartment NA NA Human Human +DTXSID7046914 Css NA 0.1292 mg/L 3compartmentss NA 50% Human Human +DTXSID7046914 Css NA 0.9303 mg/L 3compartmentss NA 95% Human Human +DTXSID7046914 Css NA 0.08735 mg/L PBTK NA 50% Human Human +DTXSID7046914 Css NA 0.5937 mg/L PBTK NA 95% Human Human +DTXSID7046914 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046914 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046914 Vd NA 0.6871 L/kg 1compartment NA NA Rat Human +DTXSID7046914 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7046914 TK.Half.Life NA 0.6816 hours 1compartment NA NA Rat Human +DTXSID7046914 Css NA 0.01643 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046914 Css NA 0.08695 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046914 Css NA 0.01091 mg/L PBTK NA 50% Rat Human +DTXSID7046914 Css NA 0.05511 mg/L PBTK NA 95% Rat Human +DTXSID7046966 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046966 Fup 0.748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7046966 Vd NA 0.4107 L/kg 1compartment NA NA Human Human DTXSID7046966 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7046966 TK.Half.Life NA 2.614 hours 1compartment NA NA Human Human -DTXSID7046966 Css NA 0.12 mg/L 3compartmentss NA 50% Human Human -DTXSID7046966 Css NA 1.164 mg/L 3compartmentss NA 95% Human Human -DTXSID7046966 Css NA 0.1146 mg/L PBTK NA 50% Human Human -DTXSID7046966 Css NA 0.836 mg/L PBTK NA 95% Human Human -DTXSID7046966 Clint NA 4.638 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046966 Fup NA 0.6233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7046966 Vd NA 1.619 L/kg 1compartment NA NA Rat Human +DTXSID7046966 TK.Half.Life NA 3.553 hours 1compartment NA NA Human Human +DTXSID7046966 Css NA 1.143 mg/L 3compartmentss NA 50% Human Human +DTXSID7046966 Css NA 6.492 mg/L 3compartmentss NA 95% Human Human +DTXSID7046966 Css NA 0.8222 mg/L PBTK NA 50% Human Human +DTXSID7046966 Css NA 4.008 mg/L PBTK NA 95% Human Human +DTXSID7046966 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046966 Fup 0.748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7046966 Vd NA 0.4362 L/kg 1compartment NA NA Rat Human DTXSID7046966 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7046966 TK.Half.Life NA 1.424 hours 1compartment NA NA Rat Human -DTXSID7046966 Css NA 0.0561 mg/L 3compartmentss NA 50% Rat Human -DTXSID7046966 Css NA 0.4709 mg/L 3compartmentss NA 95% Rat Human -DTXSID7046966 Css NA 0.05326 mg/L PBTK NA 50% Rat Human -DTXSID7046966 Css NA 0.3073 mg/L PBTK NA 95% Rat Human -DTXSID7047065 Clint NA 186.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047065 Fup NA 0.478 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047065 Vd NA 1.289 L/kg 1compartment NA NA Human Human +DTXSID7046966 TK.Half.Life NA 1.286 hours 1compartment NA NA Rat Human +DTXSID7046966 Css NA 0.06854 mg/L 3compartmentss NA 50% Rat Human +DTXSID7046966 Css NA 0.3883 mg/L 3compartmentss NA 95% Rat Human +DTXSID7046966 Css NA 0.04882 mg/L PBTK NA 50% Rat Human +DTXSID7046966 Css NA 0.2299 mg/L PBTK NA 95% Rat Human +DTXSID7047065 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047065 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047065 Vd NA 1.2 L/kg 1compartment NA NA Human Human DTXSID7047065 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047065 TK.Half.Life NA 0.8937 hours 1compartment NA NA Human Human -DTXSID7047065 Css NA 0.005208 mg/L 3compartmentss NA 50% Human Human -DTXSID7047065 Css NA 0.04877 mg/L 3compartmentss NA 95% Human Human -DTXSID7047065 Css NA 0.0043 mg/L PBTK NA 50% Human Human -DTXSID7047065 Css NA 0.03454 mg/L PBTK NA 95% Human Human -DTXSID7047065 Clint NA 186.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047065 Fup NA 0.478 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047065 Vd NA 1.113 L/kg 1compartment NA NA Rat Human +DTXSID7047065 TK.Half.Life NA 1.308 hours 1compartment NA NA Human Human +DTXSID7047065 Css NA 0.04701 mg/L 3compartmentss NA 50% Human Human +DTXSID7047065 Css NA 0.3719 mg/L 3compartmentss NA 95% Human Human +DTXSID7047065 Css NA 0.0375 mg/L PBTK NA 50% Human Human +DTXSID7047065 Css NA 0.2651 mg/L PBTK NA 95% Human Human +DTXSID7047065 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047065 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047065 Vd NA 1.035 L/kg 1compartment NA NA Rat Human DTXSID7047065 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047065 TK.Half.Life NA 0.3416 hours 1compartment NA NA Rat Human -DTXSID7047065 Css NA 0.002824 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047065 Css NA 0.02221 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047065 Css NA 0.002242 mg/L PBTK NA 50% Rat Human -DTXSID7047065 Css NA 0.01515 mg/L PBTK NA 95% Rat Human +DTXSID7047065 TK.Half.Life NA 0.5635 hours 1compartment NA NA Rat Human +DTXSID7047065 Css NA 0.00586 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047065 Css NA 0.03668 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047065 Css NA 0.004669 mg/L PBTK NA 50% Rat Human +DTXSID7047065 Css NA 0.02574 mg/L PBTK NA 95% Rat Human DTXSID7047144 Clint NA 87.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7047144 Fup NA 0.1406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047144 Vd NA 0.4699 L/kg 1compartment NA NA Human Human +DTXSID7047144 Vd NA 0.7075 L/kg 1compartment NA NA Human Human DTXSID7047144 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047144 TK.Half.Life NA 0.5484 hours 1compartment NA NA Human Human -DTXSID7047144 Css NA 0.04966 mg/L 3compartmentss NA 50% Human Human -DTXSID7047144 Css NA 0.4279 mg/L 3compartmentss NA 95% Human Human -DTXSID7047144 Css NA 0.03176 mg/L PBTK NA 50% Human Human -DTXSID7047144 Css NA 0.2592 mg/L PBTK NA 95% Human Human +DTXSID7047144 TK.Half.Life NA 0.784 hours 1compartment NA NA Human Human +DTXSID7047144 Css NA 0.0166 mg/L 3compartmentss NA 50% Human Human +DTXSID7047144 Css NA 0.2253 mg/L 3compartmentss NA 95% Human Human +DTXSID7047144 Css NA 0.01118 mg/L PBTK NA 50% Human Human +DTXSID7047144 Css NA 0.1412 mg/L PBTK NA 95% Human Human DTXSID7047144 Clint NA 87.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7047144 Fup NA 0.1406 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047144 Vd NA 0.4592 L/kg 1compartment NA NA Rat Human +DTXSID7047144 Vd NA 0.6851 L/kg 1compartment NA NA Rat Human DTXSID7047144 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047144 TK.Half.Life NA 0.2691 hours 1compartment NA NA Rat Human -DTXSID7047144 Css NA 0.02818 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047144 Css NA 0.1921 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047144 Css NA 0.01703 mg/L PBTK NA 50% Rat Human -DTXSID7047144 Css NA 0.1132 mg/L PBTK NA 95% Rat Human -DTXSID7047146 Clint NA 84.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047146 Fup NA 0.0081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047146 Vd NA 3.049 L/kg 1compartment NA NA Human Human -DTXSID7047146 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7047146 TK.Half.Life NA 23.38 hours 1compartment NA NA Human Human -DTXSID7047146 Css NA 0.8813 mg/L 3compartmentss NA 50% Human Human -DTXSID7047146 Css NA 5.673 mg/L 3compartmentss NA 95% Human Human -DTXSID7047146 Css NA 0.6074 mg/L PBTK NA 50% Human Human -DTXSID7047146 Css NA 3.732 mg/L PBTK NA 95% Human Human -DTXSID7047146 Clint NA 84.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047146 Fup NA 0.0081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047146 Vd NA 2.282 L/kg 1compartment NA NA Rat Human -DTXSID7047146 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7047146 TK.Half.Life NA 3.8 hours 1compartment NA NA Rat Human -DTXSID7047146 Css NA 0.5008 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047146 Css NA 2.515 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047146 Css NA 0.3297 mg/L PBTK NA 50% Rat Human -DTXSID7047146 Css NA 1.586 mg/L PBTK NA 95% Rat Human -DTXSID7047190 Clint NA 0.2201 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047190 Fup NA 0.071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047190 Vd NA 2.392 L/kg 1compartment NA NA Human Human -DTXSID7047190 Days.Css NA 88 Days PBTK NA NA Human Human -DTXSID7047190 TK.Half.Life NA 382.7 hours 1compartment NA NA Human Human -DTXSID7047190 Css NA 19.76 mg/L 3compartmentss NA 50% Human Human -DTXSID7047190 Css NA 60.57 mg/L 3compartmentss NA 95% Human Human -DTXSID7047190 Css NA 13.46 mg/L PBTK NA 50% Human Human -DTXSID7047190 Css NA 38.65 mg/L PBTK NA 95% Human Human -DTXSID7047190 Clint NA 0.2201 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047190 Fup NA 0.071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047190 Vd NA 1.797 L/kg 1compartment NA NA Rat Human -DTXSID7047190 Days.Css NA 26 Days PBTK NA NA Rat Human -DTXSID7047190 TK.Half.Life NA 62.05 hours 1compartment NA NA Rat Human -DTXSID7047190 Css NA 6.78 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047190 Css NA 16.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047190 Css NA 4.4 mg/L PBTK NA 50% Rat Human -DTXSID7047190 Css NA 9.878 mg/L PBTK NA 95% Rat Human -DTXSID7047192 Clint NA 17.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047192 Fup NA 0.3457 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047192 Vd NA 2.684 L/kg 1compartment NA NA Human Human -DTXSID7047192 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047192 TK.Half.Life NA 6.521 hours 1compartment NA NA Human Human -DTXSID7047192 Css NA 0.2039 mg/L 3compartmentss NA 50% Human Human -DTXSID7047192 Css NA 1.248 mg/L 3compartmentss NA 95% Human Human -DTXSID7047192 Css NA 0.1533 mg/L PBTK NA 50% Human Human -DTXSID7047192 Css NA 0.8848 mg/L PBTK NA 95% Human Human -DTXSID7047192 Clint NA 17.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047192 Fup NA 0.3457 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047192 Vd NA 2.058 L/kg 1compartment NA NA Rat Human -DTXSID7047192 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047192 TK.Half.Life NA 1.684 hours 1compartment NA NA Rat Human -DTXSID7047192 Css NA 0.1095 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047192 Css NA 0.5183 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047192 Css NA 0.07972 mg/L PBTK NA 50% Rat Human -DTXSID7047192 Css NA 0.3586 mg/L PBTK NA 95% Rat Human -DTXSID7047196 Clint NA 0.6571 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047196 Fup NA 0.8322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047196 Vd NA 1.485 L/kg 1compartment NA NA Human Human +DTXSID7047144 TK.Half.Life NA 0.3827 hours 1compartment NA NA Rat Human +DTXSID7047144 Css NA 0.0001568 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047144 Css NA 0.002054 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047144 Css NA 0.0001007 mg/L PBTK NA 50% Rat Human +DTXSID7047144 Css NA 0.001229 mg/L PBTK NA 95% Rat Human +DTXSID7047146 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047146 Fup 0.0172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047146 Vd NA 3.104 L/kg 1compartment NA NA Human Human +DTXSID7047146 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID7047146 TK.Half.Life NA 85.96 hours 1compartment NA NA Human Human +DTXSID7047146 Css NA 3.307 mg/L 3compartmentss NA 50% Human Human +DTXSID7047146 Css NA 21.16 mg/L 3compartmentss NA 95% Human Human +DTXSID7047146 Css NA 2.283 mg/L PBTK NA 50% Human Human +DTXSID7047146 Css NA 14.43 mg/L PBTK NA 95% Human Human +DTXSID7047146 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047146 Fup 0.0172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047146 Vd NA 2.324 L/kg 1compartment NA NA Rat Human +DTXSID7047146 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID7047146 TK.Half.Life NA 11.85 hours 1compartment NA NA Rat Human +DTXSID7047146 Css NA 0.4286 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047146 Css NA 2.268 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047146 Css NA 0.2949 mg/L PBTK NA 50% Rat Human +DTXSID7047146 Css NA 1.485 mg/L PBTK NA 95% Rat Human +DTXSID7047190 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047190 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047190 Vd NA 1.616 L/kg 1compartment NA NA Human Human +DTXSID7047190 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7047190 TK.Half.Life NA 4.161 hours 1compartment NA NA Human Human +DTXSID7047190 Css NA 0.26 mg/L 3compartmentss NA 50% Human Human +DTXSID7047190 Css NA 1.926 mg/L 3compartmentss NA 95% Human Human +DTXSID7047190 Css NA 0.1745 mg/L PBTK NA 50% Human Human +DTXSID7047190 Css NA 1.22 mg/L PBTK NA 95% Human Human +DTXSID7047190 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047190 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047190 Vd NA 1.24 L/kg 1compartment NA NA Rat Human +DTXSID7047190 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7047190 TK.Half.Life NA 1.567 hours 1compartment NA NA Rat Human +DTXSID7047190 Css NA 0.03345 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047190 Css NA 0.1949 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047190 Css NA 0.02219 mg/L PBTK NA 50% Rat Human +DTXSID7047190 Css NA 0.1213 mg/L PBTK NA 95% Rat Human +DTXSID7047196 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047196 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047196 Vd NA 1.081 L/kg 1compartment NA NA Human Human DTXSID7047196 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047196 TK.Half.Life NA 6.394 hours 1compartment NA NA Human Human -DTXSID7047196 Css NA 0.4358 mg/L 3compartmentss NA 50% Human Human -DTXSID7047196 Css NA 2.676 mg/L 3compartmentss NA 95% Human Human -DTXSID7047196 Css NA 0.4035 mg/L PBTK NA 50% Human Human -DTXSID7047196 Css NA 1.854 mg/L PBTK NA 95% Human Human -DTXSID7047196 Clint NA 0.6571 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047196 Fup NA 0.8322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047196 Vd NA 1.334 L/kg 1compartment NA NA Rat Human +DTXSID7047196 TK.Half.Life NA 1.088 hours 1compartment NA NA Human Human +DTXSID7047196 Css NA 0.0404 mg/L 3compartmentss NA 50% Human Human +DTXSID7047196 Css NA 0.3386 mg/L 3compartmentss NA 95% Human Human +DTXSID7047196 Css NA 0.03255 mg/L PBTK NA 50% Human Human +DTXSID7047196 Css NA 0.2376 mg/L PBTK NA 95% Human Human +DTXSID7047196 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047196 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047196 Vd NA 0.9653 L/kg 1compartment NA NA Rat Human DTXSID7047196 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047196 TK.Half.Life NA 2.402 hours 1compartment NA NA Rat Human -DTXSID7047196 Css NA 0.1516 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047196 Css NA 0.999 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047196 Css NA 0.1385 mg/L PBTK NA 50% Rat Human -DTXSID7047196 Css NA 0.6238 mg/L PBTK NA 95% Rat Human -DTXSID7047271 Clint NA 49.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047271 Fup NA 0.0126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047271 Vd NA 2.431 L/kg 1compartment NA NA Human Human -DTXSID7047271 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7047271 TK.Half.Life NA 17.59 hours 1compartment NA NA Human Human -DTXSID7047271 Css NA 1.001 mg/L 3compartmentss NA 50% Human Human -DTXSID7047271 Css NA 7.327 mg/L 3compartmentss NA 95% Human Human -DTXSID7047271 Css NA 0.6577 mg/L PBTK NA 50% Human Human -DTXSID7047271 Css NA 4.559 mg/L PBTK NA 95% Human Human -DTXSID7047271 Clint NA 49.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047271 Fup NA 0.0126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047271 Vd NA 1.81 L/kg 1compartment NA NA Rat Human +DTXSID7047196 TK.Half.Life NA 0.4854 hours 1compartment NA NA Rat Human +DTXSID7047196 Css NA 0.004947 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047196 Css NA 0.0339 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047196 Css NA 0.004003 mg/L PBTK NA 50% Rat Human +DTXSID7047196 Css NA 0.02355 mg/L PBTK NA 95% Rat Human +DTXSID7047271 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047271 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047271 Vd NA 0.3408 L/kg 1compartment NA NA Human Human +DTXSID7047271 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7047271 TK.Half.Life NA 1.082 hours 1compartment NA NA Human Human +DTXSID7047271 Css NA 0.3149 mg/L 3compartmentss NA 50% Human Human +DTXSID7047271 Css NA 1.924 mg/L 3compartmentss NA 95% Human Human +DTXSID7047271 Css NA 0.2058 mg/L PBTK NA 50% Human Human +DTXSID7047271 Css NA 1.193 mg/L PBTK NA 95% Human Human +DTXSID7047271 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047271 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047271 Vd NA 0.3555 L/kg 1compartment NA NA Rat Human DTXSID7047271 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047271 TK.Half.Life NA 4.615 hours 1compartment NA NA Rat Human -DTXSID7047271 Css NA 0.5662 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047271 Css NA 3.517 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047271 Css NA 0.3509 mg/L PBTK NA 50% Rat Human -DTXSID7047271 Css NA 2.074 mg/L PBTK NA 95% Rat Human +DTXSID7047271 TK.Half.Life NA 0.6558 hours 1compartment NA NA Rat Human +DTXSID7047271 Css NA 0.03768 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047271 Css NA 0.1621 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047271 Css NA 0.02419 mg/L PBTK NA 50% Rat Human +DTXSID7047271 Css NA 0.09688 mg/L PBTK NA 95% Rat Human DTXSID7047277 Clint 21.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7047277 Fup 0.0329 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7047277 Vd NA 2.983 L/kg 1compartment NA NA Human Human -DTXSID7047277 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID7047277 TK.Half.Life NA 49.8 hours 1compartment NA NA Human Human -DTXSID7047277 Css NA 2.005 mg/L 3compartmentss NA 50% Human Human -DTXSID7047277 Css NA 12.33 mg/L 3compartmentss NA 95% Human Human -DTXSID7047277 Css NA 1.386 mg/L PBTK NA 50% Human Human -DTXSID7047277 Css NA 8.373 mg/L PBTK NA 95% Human Human +DTXSID7047277 Vd NA 2.26 L/kg 1compartment NA NA Human Human +DTXSID7047277 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7047277 TK.Half.Life NA 18.77 hours 1compartment NA NA Human Human +DTXSID7047277 Css NA 0.9211 mg/L 3compartmentss NA 50% Human Human +DTXSID7047277 Css NA 5.966 mg/L 3compartmentss NA 95% Human Human +DTXSID7047277 Css NA 0.6182 mg/L PBTK NA 50% Human Human +DTXSID7047277 Css NA 3.836 mg/L PBTK NA 95% Human Human DTXSID7047277 Clint 21.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7047277 Fup 0.0329 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7047277 Vd NA 2.234 L/kg 1compartment NA NA Rat Human -DTXSID7047277 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID7047277 TK.Half.Life NA 8.167 hours 1compartment NA NA Rat Human -DTXSID7047277 Css NA 1.103 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047277 Css NA 5.849 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047277 Css NA 0.7288 mg/L PBTK NA 50% Rat Human -DTXSID7047277 Css NA 3.76 mg/L PBTK NA 95% Rat Human -DTXSID7047279 Clint NA 166.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047279 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047279 Vd NA 4.976 L/kg 1compartment NA NA Human Human -DTXSID7047279 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7047279 TK.Half.Life NA 22.75 hours 1compartment NA NA Human Human -DTXSID7047279 Css NA 0.4288 mg/L 3compartmentss NA 50% Human Human -DTXSID7047279 Css NA 2.537 mg/L 3compartmentss NA 95% Human Human -DTXSID7047279 Css NA 0.3444 mg/L PBTK NA 50% Human Human -DTXSID7047279 Css NA 1.969 mg/L PBTK NA 95% Human Human -DTXSID7047279 Clint NA 166.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047279 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047279 Vd NA 3.8 L/kg 1compartment NA NA Rat Human -DTXSID7047279 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7047279 TK.Half.Life NA 4.068 hours 1compartment NA NA Rat Human -DTXSID7047279 Css NA 0.2374 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047279 Css NA 1.091 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047279 Css NA 0.185 mg/L PBTK NA 50% Rat Human -DTXSID7047279 Css NA 0.8256 mg/L PBTK NA 95% Rat Human -DTXSID7047304 Clint NA 1.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047304 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047304 Vd NA 0.2257 L/kg 1compartment NA NA Human Human -DTXSID7047304 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7047304 TK.Half.Life NA 18.32 hours 1compartment NA NA Human Human -DTXSID7047304 Css NA 14.38 mg/L 3compartmentss NA 50% Human Human -DTXSID7047304 Css NA 104.4 mg/L 3compartmentss NA 95% Human Human -DTXSID7047304 Css NA 8.602 mg/L PBTK NA 50% Human Human -DTXSID7047304 Css NA 60.93 mg/L PBTK NA 95% Human Human -DTXSID7047304 Clint NA 1.749 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047304 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047304 Vd NA 0.2207 L/kg 1compartment NA NA Rat Human -DTXSID7047304 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7047304 TK.Half.Life NA 9.857 hours 1compartment NA NA Rat Human -DTXSID7047304 Css NA 6.622 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047304 Css NA 39.42 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047304 Css NA 3.673 mg/L PBTK NA 50% Rat Human -DTXSID7047304 Css NA 21.39 mg/L PBTK NA 95% Rat Human +DTXSID7047277 Vd NA 1.688 L/kg 1compartment NA NA Rat Human +DTXSID7047277 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7047277 TK.Half.Life NA 5.386 hours 1compartment NA NA Rat Human +DTXSID7047277 Css NA 0.1053 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047277 Css NA 0.5546 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047277 Css NA 0.06909 mg/L PBTK NA 50% Rat Human +DTXSID7047277 Css NA 0.3561 mg/L PBTK NA 95% Rat Human +DTXSID7047279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047279 Fup 0.00885 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047279 Vd NA 6.487 L/kg 1compartment NA NA Human Human +DTXSID7047279 Days.Css NA 36 Days PBTK NA NA Human Human +DTXSID7047279 TK.Half.Life NA 190.2 hours 1compartment NA NA Human Human +DTXSID7047279 Css NA 2.67 mg/L 3compartmentss NA 50% Human Human +DTXSID7047279 Css NA 16.53 mg/L 3compartmentss NA 95% Human Human +DTXSID7047279 Css NA 2.423 mg/L PBTK NA 50% Human Human +DTXSID7047279 Css NA 14.37 mg/L PBTK NA 95% Human Human +DTXSID7047279 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047279 Fup 0.00885 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047279 Vd NA 5.012 L/kg 1compartment NA NA Rat Human +DTXSID7047279 Days.Css NA 21 Days PBTK NA NA Rat Human +DTXSID7047279 TK.Half.Life NA 27.08 hours 1compartment NA NA Rat Human +DTXSID7047279 Css NA 0.34 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047279 Css NA 1.745 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047279 Css NA 0.3146 mg/L PBTK NA 50% Rat Human +DTXSID7047279 Css NA 1.627 mg/L PBTK NA 95% Rat Human +DTXSID7047304 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047304 Fup 0.0527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047304 Vd NA 1.418 L/kg 1compartment NA NA Human Human +DTXSID7047304 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7047304 TK.Half.Life NA 17.91 hours 1compartment NA NA Human Human +DTXSID7047304 Css NA 1.912 mg/L 3compartmentss NA 50% Human Human +DTXSID7047304 Css NA 12.8 mg/L 3compartmentss NA 95% Human Human +DTXSID7047304 Css NA 1.225 mg/L PBTK NA 50% Human Human +DTXSID7047304 Css NA 7.741 mg/L PBTK NA 95% Human Human +DTXSID7047304 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047304 Fup 0.0527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047304 Vd NA 1.069 L/kg 1compartment NA NA Rat Human +DTXSID7047304 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7047304 TK.Half.Life NA 6.925 hours 1compartment NA NA Rat Human +DTXSID7047304 Css NA 0.2345 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047304 Css NA 1.202 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047304 Css NA 0.1463 mg/L PBTK NA 50% Rat Human +DTXSID7047304 Css NA 0.7063 mg/L PBTK NA 95% Rat Human DTXSID7047306 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7047306 Fup 0.0126 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7047306 Vd NA 0.3654 L/kg 1compartment NA NA Human Human -DTXSID7047306 Days.Css NA 45 Days PBTK NA NA Human Human -DTXSID7047306 TK.Half.Life NA 191.2 hours 1compartment NA NA Human Human -DTXSID7047306 Css NA 56.28 mg/L 3compartmentss NA 50% Human Human -DTXSID7047306 Css NA 255.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7047306 Css NA 33.28 mg/L PBTK NA 50% Human Human -DTXSID7047306 Css NA 150.2 mg/L PBTK NA 95% Human Human +DTXSID7047306 Vd NA 0.2763 L/kg 1compartment NA NA Human Human +DTXSID7047306 Days.Css NA 32 Days PBTK NA NA Human Human +DTXSID7047306 TK.Half.Life NA 143 hours 1compartment NA NA Human Human +DTXSID7047306 Css NA 53.4 mg/L 3compartmentss NA 50% Human Human +DTXSID7047306 Css NA 260.2 mg/L 3compartmentss NA 95% Human Human +DTXSID7047306 Css NA 31.56 mg/L PBTK NA 50% Human Human +DTXSID7047306 Css NA 149.5 mg/L PBTK NA 95% Human Human DTXSID7047306 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7047306 Fup 0.0126 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7047306 Vd NA 0.2929 L/kg 1compartment NA NA Rat Human -DTXSID7047306 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID7047306 TK.Half.Life NA 51.5 hours 1compartment NA NA Rat Human -DTXSID7047306 Css NA 15.95 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047306 Css NA 64.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047306 Css NA 8.859 mg/L PBTK NA 50% Rat Human -DTXSID7047306 Css NA 34.96 mg/L PBTK NA 95% Rat Human -DTXSID7047308 Clint NA 20.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047308 Fup NA 0.0034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047308 Vd NA 0.4146 L/kg 1compartment NA NA Human Human -DTXSID7047308 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7047308 TK.Half.Life NA 18.55 hours 1compartment NA NA Human Human -DTXSID7047308 Css NA 8.216 mg/L 3compartmentss NA 50% Human Human -DTXSID7047308 Css NA 70.72 mg/L 3compartmentss NA 95% Human Human -DTXSID7047308 Css NA 4.896 mg/L PBTK NA 50% Human Human -DTXSID7047308 Css NA 41.11 mg/L PBTK NA 95% Human Human -DTXSID7047308 Clint NA 20.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047308 Fup NA 0.0034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047308 Vd NA 0.3324 L/kg 1compartment NA NA Rat Human -DTXSID7047308 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7047308 TK.Half.Life NA 9.939 hours 1compartment NA NA Rat Human -DTXSID7047308 Css NA 4.82 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047308 Css NA 30.39 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047308 Css NA 2.668 mg/L PBTK NA 50% Rat Human -DTXSID7047308 Css NA 16.56 mg/L PBTK NA 95% Rat Human +DTXSID7047306 Vd NA 0.235 L/kg 1compartment NA NA Rat Human +DTXSID7047306 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID7047306 TK.Half.Life NA 41.19 hours 1compartment NA NA Rat Human +DTXSID7047306 Css NA 3.564 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047306 Css NA 14.13 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047306 Css NA 2.035 mg/L PBTK NA 50% Rat Human +DTXSID7047306 Css NA 7.942 mg/L PBTK NA 95% Rat Human +DTXSID7047308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047308 Fup 0.00828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047308 Vd NA 0.5193 L/kg 1compartment NA NA Human Human +DTXSID7047308 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7047308 TK.Half.Life NA 9.97 hours 1compartment NA NA Human Human +DTXSID7047308 Css NA 3.344 mg/L 3compartmentss NA 50% Human Human +DTXSID7047308 Css NA 33.49 mg/L 3compartmentss NA 95% Human Human +DTXSID7047308 Css NA 2.049 mg/L PBTK NA 50% Human Human +DTXSID7047308 Css NA 19.82 mg/L PBTK NA 95% Human Human +DTXSID7047308 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047308 Fup 0.00828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047308 Vd NA 0.4199 L/kg 1compartment NA NA Rat Human +DTXSID7047308 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7047308 TK.Half.Life NA 5.291 hours 1compartment NA NA Rat Human +DTXSID7047308 Css NA 0.4392 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047308 Css NA 3.502 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047308 Css NA 0.2582 mg/L PBTK NA 50% Rat Human +DTXSID7047308 Css NA 2.008 mg/L PBTK NA 95% Rat Human DTXSID7047354 Clint 13.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7047354 Fup 0.0127 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7047354 Vd NA 1.273 L/kg 1compartment NA NA Human Human +DTXSID7047354 Vd NA 1.039 L/kg 1compartment NA NA Human Human DTXSID7047354 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7047354 TK.Half.Life NA 14.18 hours 1compartment NA NA Human Human -DTXSID7047354 Css NA 1.212 mg/L 3compartmentss NA 50% Human Human -DTXSID7047354 Css NA 9.241 mg/L 3compartmentss NA 95% Human Human -DTXSID7047354 Css NA 0.8124 mg/L PBTK NA 50% Human Human -DTXSID7047354 Css NA 5.837 mg/L PBTK NA 95% Human Human +DTXSID7047354 TK.Half.Life NA 14.04 hours 1compartment NA NA Human Human +DTXSID7047354 Css NA 1.449 mg/L 3compartmentss NA 50% Human Human +DTXSID7047354 Css NA 11.24 mg/L 3compartmentss NA 95% Human Human +DTXSID7047354 Css NA 0.9518 mg/L PBTK NA 50% Human Human +DTXSID7047354 Css NA 7.002 mg/L PBTK NA 95% Human Human DTXSID7047354 Clint 13.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7047354 Fup 0.0127 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7047354 Vd NA 1.171 L/kg 1compartment NA NA Rat Human +DTXSID7047354 Vd NA 0.9788 L/kg 1compartment NA NA Rat Human DTXSID7047354 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047354 TK.Half.Life NA 8.31 hours 1compartment NA NA Rat Human -DTXSID7047354 Css NA 0.6838 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047354 Css NA 4.038 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047354 Css NA 0.4281 mg/L PBTK NA 50% Rat Human -DTXSID7047354 Css NA 2.381 mg/L PBTK NA 95% Rat Human +DTXSID7047354 TK.Half.Life NA 8.633 hours 1compartment NA NA Rat Human +DTXSID7047354 Css NA 0.1929 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047354 Css NA 1.141 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047354 Css NA 0.1219 mg/L PBTK NA 50% Rat Human +DTXSID7047354 Css NA 0.6849 mg/L PBTK NA 95% Rat Human DTXSID7047356 Clint 5.55 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7047356 Fup 0.319 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7047356 Vd NA 0.6212 L/kg 1compartment NA NA Human Human +DTXSID7047356 Vd NA 0.6254 L/kg 1compartment NA NA Human Human DTXSID7047356 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047356 TK.Half.Life NA 1.592 hours 1compartment NA NA Human Human -DTXSID7047356 Css NA 0.2198 mg/L 3compartmentss NA 50% Human Human -DTXSID7047356 Css NA 1.273 mg/L 3compartmentss NA 95% Human Human -DTXSID7047356 Css NA 0.1703 mg/L PBTK NA 50% Human Human -DTXSID7047356 Css NA 0.9115 mg/L PBTK NA 95% Human Human +DTXSID7047356 TK.Half.Life NA 1.603 hours 1compartment NA NA Human Human +DTXSID7047356 Css NA 0.05679 mg/L 3compartmentss NA 50% Human Human +DTXSID7047356 Css NA 0.3965 mg/L 3compartmentss NA 95% Human Human +DTXSID7047356 Css NA 0.04443 mg/L PBTK NA 50% Human Human +DTXSID7047356 Css NA 0.28 mg/L PBTK NA 95% Human Human DTXSID7047356 Clint 5.55 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7047356 Fup 0.319 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7047356 Vd NA 0.6153 L/kg 1compartment NA NA Rat Human +DTXSID7047356 Vd NA 0.6191 L/kg 1compartment NA NA Rat Human DTXSID7047356 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047356 TK.Half.Life NA 0.9049 hours 1compartment NA NA Rat Human -DTXSID7047356 Css NA 0.1089 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047356 Css NA 0.4406 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047356 Css NA 0.08207 mg/L PBTK NA 50% Rat Human -DTXSID7047356 Css NA 0.2968 mg/L PBTK NA 95% Rat Human +DTXSID7047356 TK.Half.Life NA 0.9101 hours 1compartment NA NA Rat Human +DTXSID7047356 Css NA 0.0004232 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047356 Css NA 0.002172 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047356 Css NA 0.0003223 mg/L PBTK NA 50% Rat Human +DTXSID7047356 Css NA 0.001465 mg/L PBTK NA 95% Rat Human DTXSID7047358 Clint 35.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7047358 Fup 0.0608 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7047358 Vd NA 0.2801 L/kg 1compartment NA NA Human Human +DTXSID7047358 Vd NA 0.3912 L/kg 1compartment NA NA Human Human DTXSID7047358 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047358 TK.Half.Life NA 0.7496 hours 1compartment NA NA Human Human -DTXSID7047358 Css NA 0.2522 mg/L 3compartmentss NA 50% Human Human -DTXSID7047358 Css NA 1.859 mg/L 3compartmentss NA 95% Human Human -DTXSID7047358 Css NA 0.1563 mg/L PBTK NA 50% Human Human -DTXSID7047358 Css NA 1.126 mg/L PBTK NA 95% Human Human +DTXSID7047358 TK.Half.Life NA 1.025 hours 1compartment NA NA Human Human +DTXSID7047358 Css NA 0.2116 mg/L 3compartmentss NA 50% Human Human +DTXSID7047358 Css NA 1.65 mg/L 3compartmentss NA 95% Human Human +DTXSID7047358 Css NA 0.1363 mg/L PBTK NA 50% Human Human +DTXSID7047358 Css NA 1.027 mg/L PBTK NA 95% Human Human DTXSID7047358 Clint 35.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7047358 Fup 0.0608 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7047358 Vd NA 0.2707 L/kg 1compartment NA NA Rat Human +DTXSID7047358 Vd NA 0.3601 L/kg 1compartment NA NA Rat Human DTXSID7047358 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047358 TK.Half.Life NA 0.4348 hours 1compartment NA NA Rat Human -DTXSID7047358 Css NA 0.1405 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047358 Css NA 0.7861 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047358 Css NA 0.08161 mg/L PBTK NA 50% Rat Human -DTXSID7047358 Css NA 0.4495 mg/L PBTK NA 95% Rat Human +DTXSID7047358 TK.Half.Life NA 0.5658 hours 1compartment NA NA Rat Human +DTXSID7047358 Css NA 0.01613 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047358 Css NA 0.1105 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047358 Css NA 0.01012 mg/L PBTK NA 50% Rat Human +DTXSID7047358 Css NA 0.06563 mg/L PBTK NA 95% Rat Human DTXSID7047433 Clint 9.74 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7047433 Fup 0.0583 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7047433 Vd NA 2.277 L/kg 1compartment NA NA Human Human -DTXSID7047433 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7047433 TK.Half.Life NA 25.28 hours 1compartment NA NA Human Human -DTXSID7047433 Css NA 1.288 mg/L 3compartmentss NA 50% Human Human -DTXSID7047433 Css NA 7.539 mg/L 3compartmentss NA 95% Human Human -DTXSID7047433 Css NA 0.8747 mg/L PBTK NA 50% Human Human -DTXSID7047433 Css NA 4.945 mg/L PBTK NA 95% Human Human +DTXSID7047433 Vd NA 1.843 L/kg 1compartment NA NA Human Human +DTXSID7047433 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7047433 TK.Half.Life NA 16.59 hours 1compartment NA NA Human Human +DTXSID7047433 Css NA 0.9962 mg/L 3compartmentss NA 50% Human Human +DTXSID7047433 Css NA 6.267 mg/L 3compartmentss NA 95% Human Human +DTXSID7047433 Css NA 0.6654 mg/L PBTK NA 50% Human Human +DTXSID7047433 Css NA 4.024 mg/L PBTK NA 95% Human Human DTXSID7047433 Clint 9.74 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7047433 Fup 0.0583 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7047433 Vd NA 1.708 L/kg 1compartment NA NA Rat Human -DTXSID7047433 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7047433 TK.Half.Life NA 7.085 hours 1compartment NA NA Rat Human -DTXSID7047433 Css NA 0.6994 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047433 Css NA 3.062 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047433 Css NA 0.453 mg/L PBTK NA 50% Rat Human -DTXSID7047433 Css NA 1.93 mg/L PBTK NA 95% Rat Human -DTXSID7047435 Clint NA 7.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047435 Fup NA 0.1146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047435 Vd NA 0.6455 L/kg 1compartment NA NA Human Human +DTXSID7047433 Vd NA 1.384 L/kg 1compartment NA NA Rat Human +DTXSID7047433 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7047433 TK.Half.Life NA 5.658 hours 1compartment NA NA Rat Human +DTXSID7047433 Css NA 0.126 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047433 Css NA 0.5745 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047433 Css NA 0.08284 mg/L PBTK NA 50% Rat Human +DTXSID7047433 Css NA 0.3586 mg/L PBTK NA 95% Rat Human +DTXSID7047435 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047435 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047435 Vd NA 0.9304 L/kg 1compartment NA NA Human Human DTXSID7047435 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047435 TK.Half.Life NA 3.167 hours 1compartment NA NA Human Human -DTXSID7047435 Css NA 0.6752 mg/L 3compartmentss NA 50% Human Human -DTXSID7047435 Css NA 4.662 mg/L 3compartmentss NA 95% Human Human -DTXSID7047435 Css NA 0.4303 mg/L PBTK NA 50% Human Human -DTXSID7047435 Css NA 2.796 mg/L PBTK NA 95% Human Human -DTXSID7047435 Clint NA 7.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047435 Fup NA 0.1146 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047435 Vd NA 0.5337 L/kg 1compartment NA NA Rat Human +DTXSID7047435 TK.Half.Life NA 1.443 hours 1compartment NA NA Human Human +DTXSID7047435 Css NA 0.09464 mg/L 3compartmentss NA 50% Human Human +DTXSID7047435 Css NA 0.6659 mg/L 3compartmentss NA 95% Human Human +DTXSID7047435 Css NA 0.06618 mg/L PBTK NA 50% Human Human +DTXSID7047435 Css NA 0.438 mg/L PBTK NA 95% Human Human +DTXSID7047435 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047435 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047435 Vd NA 0.7713 L/kg 1compartment NA NA Rat Human DTXSID7047435 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047435 TK.Half.Life NA 1.55 hours 1compartment NA NA Rat Human -DTXSID7047435 Css NA 0.3612 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047435 Css NA 1.902 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047435 Css NA 0.2162 mg/L PBTK NA 50% Rat Human -DTXSID7047435 Css NA 1.072 mg/L PBTK NA 95% Rat Human -DTXSID7047437 Clint NA 0.1051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047437 Fup NA 0.1904 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047437 Vd NA 2.62 L/kg 1compartment NA NA Human Human -DTXSID7047437 Days.Css NA 54 Days PBTK NA NA Human Human -DTXSID7047437 TK.Half.Life NA 253.3 hours 1compartment NA NA Human Human -DTXSID7047437 Css NA 10.7 mg/L 3compartmentss NA 50% Human Human -DTXSID7047437 Css NA 31.17 mg/L 3compartmentss NA 95% Human Human -DTXSID7047437 Css NA 7.766 mg/L PBTK NA 50% Human Human -DTXSID7047437 Css NA 20.49 mg/L PBTK NA 95% Human Human -DTXSID7047437 Clint NA 0.1051 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047437 Fup NA 0.1904 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047437 Vd NA 1.989 L/kg 1compartment NA NA Rat Human -DTXSID7047437 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID7047437 TK.Half.Life NA 33.05 hours 1compartment NA NA Rat Human -DTXSID7047437 Css NA 3.288 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047437 Css NA 7.714 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047437 Css NA 2.278 mg/L PBTK NA 50% Rat Human -DTXSID7047437 Css NA 4.727 mg/L PBTK NA 95% Rat Human -DTXSID7047487 Clint NA 9.307 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047487 Fup NA 0.1099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047487 Vd NA 0.2786 L/kg 1compartment NA NA Human Human -DTXSID7047487 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047487 TK.Half.Life NA 1.221 hours 1compartment NA NA Human Human -DTXSID7047487 Css NA 0.6058 mg/L 3compartmentss NA 50% Human Human -DTXSID7047487 Css NA 4.433 mg/L 3compartmentss NA 95% Human Human -DTXSID7047487 Css NA 0.3716 mg/L PBTK NA 50% Human Human -DTXSID7047487 Css NA 2.647 mg/L PBTK NA 95% Human Human -DTXSID7047487 Clint NA 9.307 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047487 Fup NA 0.1099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047487 Vd NA 0.2713 L/kg 1compartment NA NA Rat Human +DTXSID7047435 TK.Half.Life NA 0.6319 hours 1compartment NA NA Rat Human +DTXSID7047435 Css NA 0.01222 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047435 Css NA 0.06654 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047435 Css NA 0.008418 mg/L PBTK NA 50% Rat Human +DTXSID7047435 Css NA 0.04316 mg/L PBTK NA 95% Rat Human +DTXSID7047437 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047437 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047437 Vd NA 2.245 L/kg 1compartment NA NA Human Human +DTXSID7047437 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7047437 TK.Half.Life NA 4.516 hours 1compartment NA NA Human Human +DTXSID7047437 Css NA 0.1505 mg/L 3compartmentss NA 50% Human Human +DTXSID7047437 Css NA 0.969 mg/L 3compartmentss NA 95% Human Human +DTXSID7047437 Css NA 0.111 mg/L PBTK NA 50% Human Human +DTXSID7047437 Css NA 0.6774 mg/L PBTK NA 95% Human Human +DTXSID7047437 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047437 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047437 Vd NA 1.729 L/kg 1compartment NA NA Rat Human +DTXSID7047437 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7047437 TK.Half.Life NA 1.428 hours 1compartment NA NA Rat Human +DTXSID7047437 Css NA 0.01867 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047437 Css NA 0.09265 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047437 Css NA 0.01373 mg/L PBTK NA 50% Rat Human +DTXSID7047437 Css NA 0.06542 mg/L PBTK NA 95% Rat Human +DTXSID7047487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047487 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047487 Vd NA 0.7963 L/kg 1compartment NA NA Human Human +DTXSID7047487 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7047487 TK.Half.Life NA 17.43 hours 1compartment NA NA Human Human +DTXSID7047487 Css NA 2.369 mg/L 3compartmentss NA 50% Human Human +DTXSID7047487 Css NA 9.442 mg/L 3compartmentss NA 95% Human Human +DTXSID7047487 Css NA 1.736 mg/L PBTK NA 50% Human Human +DTXSID7047487 Css NA 6.082 mg/L PBTK NA 95% Human Human +DTXSID7047487 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047487 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047487 Vd NA 0.7314 L/kg 1compartment NA NA Rat Human DTXSID7047487 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047487 TK.Half.Life NA 0.7247 hours 1compartment NA NA Rat Human -DTXSID7047487 Css NA 0.3306 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047487 Css NA 1.746 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047487 Css NA 0.1906 mg/L PBTK NA 50% Rat Human -DTXSID7047487 Css NA 0.9769 mg/L PBTK NA 95% Rat Human -DTXSID7047512 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047512 Fup NA 0.7156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047512 Vd NA 0.5553 L/kg 1compartment NA NA Human Human -DTXSID7047512 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047512 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human -DTXSID7047512 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human -DTXSID7047512 Css NA 6.927 mg/L 3compartmentss NA 95% Human Human -DTXSID7047512 Css NA 0.8629 mg/L PBTK NA 50% Human Human -DTXSID7047512 Css NA 4.361 mg/L PBTK NA 95% Human Human -DTXSID7047512 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047512 Fup NA 0.7156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047512 Vd NA 0.5995 L/kg 1compartment NA NA Rat Human -DTXSID7047512 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047512 TK.Half.Life NA 1.847 hours 1compartment NA NA Rat Human -DTXSID7047512 Css NA 0.2928 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047512 Css NA 1.822 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047512 Css NA 0.2184 mg/L PBTK NA 50% Rat Human -DTXSID7047512 Css NA 1.061 mg/L PBTK NA 95% Rat Human -DTXSID7047518 Clint NA 5.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047518 Fup NA 0.3704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047518 Vd NA 2.724 L/kg 1compartment NA NA Human Human +DTXSID7047487 TK.Half.Life NA 5.328 hours 1compartment NA NA Rat Human +DTXSID7047487 Css NA 0.1523 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047487 Css NA 0.5081 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047487 Css NA 0.1106 mg/L PBTK NA 50% Rat Human +DTXSID7047487 Css NA 0.3139 mg/L PBTK NA 95% Rat Human +DTXSID7047510 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047510 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047510 Vd NA 2.279 L/kg 1compartment NA NA Human Human +DTXSID7047510 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7047510 TK.Half.Life NA 6.984 hours 1compartment NA NA Human Human +DTXSID7047510 Css NA 0.3114 mg/L 3compartmentss NA 50% Human Human +DTXSID7047510 Css NA 2.133 mg/L 3compartmentss NA 95% Human Human +DTXSID7047510 Css NA 0.2169 mg/L PBTK NA 50% Human Human +DTXSID7047510 Css NA 1.374 mg/L PBTK NA 95% Human Human +DTXSID7047510 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047510 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047510 Vd NA 1.73 L/kg 1compartment NA NA Rat Human +DTXSID7047510 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7047510 TK.Half.Life NA 2.097 hours 1compartment NA NA Rat Human +DTXSID7047510 Css NA 0.03944 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047510 Css NA 0.2178 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047510 Css NA 0.02705 mg/L PBTK NA 50% Rat Human +DTXSID7047510 Css NA 0.1405 mg/L PBTK NA 95% Rat Human +DTXSID7047518 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047518 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047518 Vd NA 3.214 L/kg 1compartment NA NA Human Human DTXSID7047518 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047518 TK.Half.Life NA 5.733 hours 1compartment NA NA Human Human -DTXSID7047518 Css NA 0.1424 mg/L 3compartmentss NA 50% Human Human -DTXSID7047518 Css NA 1.011 mg/L 3compartmentss NA 95% Human Human -DTXSID7047518 Css NA 0.1487 mg/L PBTK NA 50% Human Human -DTXSID7047518 Css NA 0.8253 mg/L PBTK NA 95% Human Human -DTXSID7047518 Clint NA 5.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047518 Fup NA 0.3704 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047518 Vd NA 2.753 L/kg 1compartment NA NA Rat Human +DTXSID7047518 TK.Half.Life NA 3.329 hours 1compartment NA NA Human Human +DTXSID7047518 Css NA 0.04338 mg/L 3compartmentss NA 50% Human Human +DTXSID7047518 Css NA 0.3863 mg/L 3compartmentss NA 95% Human Human +DTXSID7047518 Css NA 0.04672 mg/L PBTK NA 50% Human Human +DTXSID7047518 Css NA 0.3415 mg/L PBTK NA 95% Human Human +DTXSID7047518 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047518 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047518 Vd NA 3.21 L/kg 1compartment NA NA Rat Human DTXSID7047518 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047518 TK.Half.Life NA 3.336 hours 1compartment NA NA Rat Human -DTXSID7047518 Css NA 0.06976 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047518 Css NA 0.3941 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047518 Css NA 0.07212 mg/L PBTK NA 50% Rat Human -DTXSID7047518 Css NA 0.2964 mg/L PBTK NA 95% Rat Human +DTXSID7047518 TK.Half.Life NA 1.799 hours 1compartment NA NA Rat Human +DTXSID7047518 Css NA 0.00535 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047518 Css NA 0.03622 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047518 Css NA 0.005983 mg/L PBTK NA 50% Rat Human +DTXSID7047518 Css NA 0.03184 mg/L PBTK NA 95% Rat Human DTXSID7047568 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7047568 Fup 0.693 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7047568 Vd NA 1.013 L/kg 1compartment NA NA Human Human DTXSID7047568 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID7047568 TK.Half.Life NA 9.781 hours 1compartment NA NA Human Human -DTXSID7047568 Css NA 0.8884 mg/L 3compartmentss NA 50% Human Human -DTXSID7047568 Css NA 2.739 mg/L 3compartmentss NA 95% Human Human -DTXSID7047568 Css NA 0.7897 mg/L PBTK NA 50% Human Human -DTXSID7047568 Css NA 2.074 mg/L PBTK NA 95% Human Human +DTXSID7047568 Css NA 0.8601 mg/L 3compartmentss NA 50% Human Human +DTXSID7047568 Css NA 2.625 mg/L 3compartmentss NA 95% Human Human +DTXSID7047568 Css NA 0.762 mg/L PBTK NA 50% Human Human +DTXSID7047568 Css NA 1.995 mg/L PBTK NA 95% Human Human DTXSID7047568 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7047568 Fup 0.693 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7047568 Vd NA 0.964 L/kg 1compartment NA NA Rat Human DTXSID7047568 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID7047568 TK.Half.Life NA 3.092 hours 1compartment NA NA Rat Human -DTXSID7047568 Css NA 0.2332 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047568 Css NA 0.6039 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047568 Css NA 0.2027 mg/L PBTK NA 50% Rat Human -DTXSID7047568 Css NA 0.4217 mg/L PBTK NA 95% Rat Human -DTXSID7047641 Clint NA 1.054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047641 Fup NA 0.0267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047641 Vd NA 3.121 L/kg 1compartment NA NA Human Human -DTXSID7047641 Days.Css NA 463 Days PBTK NA NA Human Human -DTXSID7047641 TK.Half.Life NA 1756 hours 1compartment NA NA Human Human -DTXSID7047641 Css NA 69.3 mg/L 3compartmentss NA 50% Human Human -DTXSID7047641 Css NA 406.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7047641 Css NA 48.19 mg/L PBTK NA 50% Human Human -DTXSID7047641 Css NA 274.4 mg/L PBTK NA 95% Human Human -DTXSID7047641 Clint NA 1.054 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047641 Fup NA 0.0267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047641 Vd NA 2.338 L/kg 1compartment NA NA Rat Human -DTXSID7047641 Days.Css NA 237 Days PBTK NA NA Rat Human -DTXSID7047641 TK.Half.Life NA 221.9 hours 1compartment NA NA Rat Human -DTXSID7047641 Css NA 38.52 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047641 Css NA 153.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047641 Css NA 25.58 mg/L PBTK NA 50% Rat Human -DTXSID7047641 Css NA 99.44 mg/L PBTK NA 95% Rat Human -DTXSID7047643 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047643 Fup NA 0.4629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047643 Vd NA 2.061 L/kg 1compartment NA NA Human Human -DTXSID7047643 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID7047643 TK.Half.Life NA 47.8 hours 1compartment NA NA Human Human -DTXSID7047643 Css NA 2.37 mg/L 3compartmentss NA 50% Human Human -DTXSID7047643 Css NA 9.345 mg/L 3compartmentss NA 95% Human Human -DTXSID7047643 Css NA 1.948 mg/L PBTK NA 50% Human Human -DTXSID7047643 Css NA 6.354 mg/L PBTK NA 95% Human Human -DTXSID7047643 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047643 Fup NA 0.4629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047643 Vd NA 1.65 L/kg 1compartment NA NA Rat Human -DTXSID7047643 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7047643 TK.Half.Life NA 9.092 hours 1compartment NA NA Rat Human -DTXSID7047643 Css NA 0.6322 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047643 Css NA 2.145 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047643 Css NA 0.5035 mg/L PBTK NA 50% Rat Human -DTXSID7047643 Css NA 1.362 mg/L PBTK NA 95% Rat Human -DTXSID7047645 Clint NA 414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047645 Fup NA 0.3205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047645 Vd NA 1.743 L/kg 1compartment NA NA Human Human +DTXSID7047568 Css NA 0.05244 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047568 Css NA 0.1346 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047568 Css NA 0.04728 mg/L PBTK NA 50% Rat Human +DTXSID7047568 Css NA 0.09762 mg/L PBTK NA 95% Rat Human +DTXSID7047643 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047643 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047643 Vd NA 1.273 L/kg 1compartment NA NA Human Human +DTXSID7047643 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7047643 TK.Half.Life NA 1.311 hours 1compartment NA NA Human Human +DTXSID7047643 Css NA 0.04216 mg/L 3compartmentss NA 50% Human Human +DTXSID7047643 Css NA 0.3646 mg/L 3compartmentss NA 95% Human Human +DTXSID7047643 Css NA 0.03416 mg/L PBTK NA 50% Human Human +DTXSID7047643 Css NA 0.2565 mg/L PBTK NA 95% Human Human +DTXSID7047643 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047643 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047643 Vd NA 1.099 L/kg 1compartment NA NA Rat Human +DTXSID7047643 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7047643 TK.Half.Life NA 0.5585 hours 1compartment NA NA Rat Human +DTXSID7047643 Css NA 0.00524 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047643 Css NA 0.03451 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047643 Css NA 0.004315 mg/L PBTK NA 50% Rat Human +DTXSID7047643 Css NA 0.02412 mg/L PBTK NA 95% Rat Human +DTXSID7047645 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047645 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047645 Vd NA 1.398 L/kg 1compartment NA NA Human Human DTXSID7047645 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047645 TK.Half.Life NA 1.303 hours 1compartment NA NA Human Human -DTXSID7047645 Css NA 0.004434 mg/L 3compartmentss NA 50% Human Human -DTXSID7047645 Css NA 0.03324 mg/L 3compartmentss NA 95% Human Human -DTXSID7047645 Css NA 0.003424 mg/L PBTK NA 50% Human Human -DTXSID7047645 Css NA 0.02357 mg/L PBTK NA 95% Human Human -DTXSID7047645 Clint NA 414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047645 Fup NA 0.3205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047645 Vd NA 1.392 L/kg 1compartment NA NA Rat Human +DTXSID7047645 TK.Half.Life NA 2.446 hours 1compartment NA NA Human Human +DTXSID7047645 Css NA 0.1192 mg/L 3compartmentss NA 50% Human Human +DTXSID7047645 Css NA 0.8172 mg/L 3compartmentss NA 95% Human Human +DTXSID7047645 Css NA 0.08514 mg/L PBTK NA 50% Human Human +DTXSID7047645 Css NA 0.5452 mg/L PBTK NA 95% Human Human +DTXSID7047645 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047645 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047645 Vd NA 1.11 L/kg 1compartment NA NA Rat Human DTXSID7047645 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047645 TK.Half.Life NA 0.4536 hours 1compartment NA NA Rat Human -DTXSID7047645 Css NA 0.002445 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047645 Css NA 0.01554 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047645 Css NA 0.001806 mg/L PBTK NA 50% Rat Human -DTXSID7047645 Css NA 0.01067 mg/L PBTK NA 95% Rat Human -DTXSID7047647 Clint NA 33.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047647 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047647 Vd NA 2.744 L/kg 1compartment NA NA Human Human -DTXSID7047647 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7047647 TK.Half.Life NA 26.48 hours 1compartment NA NA Human Human -DTXSID7047647 Css NA 1.276 mg/L 3compartmentss NA 50% Human Human -DTXSID7047647 Css NA 9.029 mg/L 3compartmentss NA 95% Human Human -DTXSID7047647 Css NA 0.8577 mg/L PBTK NA 50% Human Human -DTXSID7047647 Css NA 5.89 mg/L PBTK NA 95% Human Human -DTXSID7047647 Clint NA 33.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047647 Fup NA 0.0207 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047647 Vd NA 2.051 L/kg 1compartment NA NA Rat Human -DTXSID7047647 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7047647 TK.Half.Life NA 5.581 hours 1compartment NA NA Rat Human -DTXSID7047647 Css NA 0.7164 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047647 Css NA 4.126 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047647 Css NA 0.4594 mg/L PBTK NA 50% Rat Human -DTXSID7047647 Css NA 2.574 mg/L PBTK NA 95% Rat Human -DTXSID7047649 Clint NA 201.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047649 Fup NA 0.3762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047649 Vd NA 1.302 L/kg 1compartment NA NA Human Human +DTXSID7047645 TK.Half.Life NA 0.9819 hours 1compartment NA NA Rat Human +DTXSID7047645 Css NA 0.01508 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047645 Css NA 0.07917 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047645 Css NA 0.01069 mg/L PBTK NA 50% Rat Human +DTXSID7047645 Css NA 0.05226 mg/L PBTK NA 95% Rat Human +DTXSID7047647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047647 Fup 0.00616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047647 Vd NA 2.156 L/kg 1compartment NA NA Human Human +DTXSID7047647 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID7047647 TK.Half.Life NA 44.49 hours 1compartment NA NA Human Human +DTXSID7047647 Css NA 3.212 mg/L 3compartmentss NA 50% Human Human +DTXSID7047647 Css NA 25.65 mg/L 3compartmentss NA 95% Human Human +DTXSID7047647 Css NA 2.053 mg/L PBTK NA 50% Human Human +DTXSID7047647 Css NA 15.91 mg/L PBTK NA 95% Human Human +DTXSID7047647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047647 Fup 0.00616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047647 Vd NA 1.597 L/kg 1compartment NA NA Rat Human +DTXSID7047647 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7047647 TK.Half.Life NA 13.22 hours 1compartment NA NA Rat Human +DTXSID7047647 Css NA 0.4087 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047647 Css NA 2.826 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047647 Css NA 0.2572 mg/L PBTK NA 50% Rat Human +DTXSID7047647 Css NA 1.704 mg/L PBTK NA 95% Rat Human +DTXSID7047649 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047649 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047649 Vd NA 1.239 L/kg 1compartment NA NA Human Human DTXSID7047649 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047649 TK.Half.Life NA 0.9685 hours 1compartment NA NA Human Human -DTXSID7047649 Css NA 0.006556 mg/L 3compartmentss NA 50% Human Human -DTXSID7047649 Css NA 0.05108 mg/L 3compartmentss NA 95% Human Human -DTXSID7047649 Css NA 0.005108 mg/L PBTK NA 50% Human Human -DTXSID7047649 Css NA 0.03646 mg/L PBTK NA 95% Human Human -DTXSID7047649 Clint NA 201.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047649 Fup NA 0.3762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047649 Vd NA 1.095 L/kg 1compartment NA NA Rat Human +DTXSID7047649 TK.Half.Life NA 2.826 hours 1compartment NA NA Human Human +DTXSID7047649 Css NA 0.1829 mg/L 3compartmentss NA 50% Human Human +DTXSID7047649 Css NA 1.192 mg/L 3compartmentss NA 95% Human Human +DTXSID7047649 Css NA 0.1427 mg/L PBTK NA 50% Human Human +DTXSID7047649 Css NA 0.8284 mg/L PBTK NA 95% Human Human +DTXSID7047649 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047649 Fup 0.368 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047649 Vd NA 1.048 L/kg 1compartment NA NA Rat Human DTXSID7047649 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047649 TK.Half.Life NA 0.362 hours 1compartment NA NA Rat Human -DTXSID7047649 Css NA 0.00353 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047649 Css NA 0.02428 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047649 Css NA 0.002668 mg/L PBTK NA 50% Rat Human -DTXSID7047649 Css NA 0.01646 mg/L PBTK NA 95% Rat Human -DTXSID7047693 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047693 Fup NA 0.8771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047693 Vd NA 0.8453 L/kg 1compartment NA NA Human Human +DTXSID7047649 TK.Half.Life NA 1.258 hours 1compartment NA NA Rat Human +DTXSID7047649 Css NA 0.02144 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047649 Css NA 0.1065 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047649 Css NA 0.01673 mg/L PBTK NA 50% Rat Human +DTXSID7047649 Css NA 0.0706 mg/L PBTK NA 95% Rat Human +DTXSID7047693 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047693 Fup 0.586 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047693 Vd NA 0.6811 L/kg 1compartment NA NA Human Human DTXSID7047693 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047693 TK.Half.Life NA 6.267 hours 1compartment NA NA Human Human -DTXSID7047693 Css NA 0.915 mg/L 3compartmentss NA 50% Human Human -DTXSID7047693 Css NA 5.216 mg/L 3compartmentss NA 95% Human Human -DTXSID7047693 Css NA 0.7776 mg/L PBTK NA 50% Human Human -DTXSID7047693 Css NA 3.458 mg/L PBTK NA 95% Human Human -DTXSID7047693 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047693 Fup NA 0.8771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047693 Vd NA 0.8608 L/kg 1compartment NA NA Rat Human +DTXSID7047693 TK.Half.Life NA 7.55 hours 1compartment NA NA Human Human +DTXSID7047693 Css NA 1.069 mg/L 3compartmentss NA 50% Human Human +DTXSID7047693 Css NA 7.331 mg/L 3compartmentss NA 95% Human Human +DTXSID7047693 Css NA 0.8531 mg/L PBTK NA 50% Human Human +DTXSID7047693 Css NA 4.641 mg/L PBTK NA 95% Human Human +DTXSID7047693 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047693 Fup 0.586 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047693 Vd NA 0.6888 L/kg 1compartment NA NA Rat Human DTXSID7047693 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047693 TK.Half.Life NA 2.167 hours 1compartment NA NA Rat Human -DTXSID7047693 Css NA 0.233 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047693 Css NA 1.385 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047693 Css NA 0.1926 mg/L PBTK NA 50% Rat Human -DTXSID7047693 Css NA 0.8389 mg/L PBTK NA 95% Rat Human +DTXSID7047693 TK.Half.Life NA 2.595 hours 1compartment NA NA Rat Human +DTXSID7047693 Css NA 0.02039 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047693 Css NA 0.1825 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047693 Css NA 0.01564 mg/L PBTK NA 50% Rat Human +DTXSID7047693 Css NA 0.1141 mg/L PBTK NA 95% Rat Human DTXSID7047697 Clint 846 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7047697 Fup 0.00653 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7047697 Vd NA 0.8848 L/kg 1compartment NA NA Human Human +DTXSID7047697 Vd NA 0.7742 L/kg 1compartment NA NA Human Human DTXSID7047697 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047697 TK.Half.Life NA 1.314 hours 1compartment NA NA Human Human -DTXSID7047697 Css NA 0.09388 mg/L 3compartmentss NA 50% Human Human -DTXSID7047697 Css NA 0.9789 mg/L 3compartmentss NA 95% Human Human -DTXSID7047697 Css NA 0.05618 mg/L PBTK NA 50% Human Human -DTXSID7047697 Css NA 0.5618 mg/L PBTK NA 95% Human Human +DTXSID7047697 TK.Half.Life NA 1.164 hours 1compartment NA NA Human Human +DTXSID7047697 Css NA 0.09166 mg/L 3compartmentss NA 50% Human Human +DTXSID7047697 Css NA 0.9826 mg/L 3compartmentss NA 95% Human Human +DTXSID7047697 Css NA 0.0547 mg/L PBTK NA 50% Human Human +DTXSID7047697 Css NA 0.579 mg/L PBTK NA 95% Human Human DTXSID7047697 Clint 846 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7047697 Fup 0.00653 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7047697 Vd NA 0.6516 L/kg 1compartment NA NA Rat Human +DTXSID7047697 Vd NA 0.5724 L/kg 1compartment NA NA Rat Human DTXSID7047697 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047697 TK.Half.Life NA 0.4919 hours 1compartment NA NA Rat Human -DTXSID7047697 Css NA 0.05486 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047697 Css NA 0.437 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047697 Css NA 0.03065 mg/L PBTK NA 50% Rat Human -DTXSID7047697 Css NA 0.2387 mg/L PBTK NA 95% Rat Human -DTXSID7047726 Clint NA 39.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047726 Fup NA 0.1312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047726 Vd NA 1.947 L/kg 1compartment NA NA Human Human +DTXSID7047697 TK.Half.Life NA 0.4426 hours 1compartment NA NA Rat Human +DTXSID7047697 Css NA 0.01248 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047697 Css NA 0.1084 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047697 Css NA 0.007212 mg/L PBTK NA 50% Rat Human +DTXSID7047697 Css NA 0.06171 mg/L PBTK NA 95% Rat Human +DTXSID7047726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047726 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047726 Vd NA 1.328 L/kg 1compartment NA NA Human Human DTXSID7047726 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047726 TK.Half.Life NA 3.599 hours 1compartment NA NA Human Human -DTXSID7047726 Css NA 0.1546 mg/L 3compartmentss NA 50% Human Human -DTXSID7047726 Css NA 1.118 mg/L 3compartmentss NA 95% Human Human -DTXSID7047726 Css NA 0.1063 mg/L PBTK NA 50% Human Human -DTXSID7047726 Css NA 0.7366 mg/L PBTK NA 95% Human Human -DTXSID7047726 Clint NA 39.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047726 Fup NA 0.1312 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047726 Vd NA 1.485 L/kg 1compartment NA NA Rat Human +DTXSID7047726 TK.Half.Life NA 3.625 hours 1compartment NA NA Human Human +DTXSID7047726 Css NA 0.2951 mg/L 3compartmentss NA 50% Human Human +DTXSID7047726 Css NA 2.246 mg/L 3compartmentss NA 95% Human Human +DTXSID7047726 Css NA 0.1949 mg/L PBTK NA 50% Human Human +DTXSID7047726 Css NA 1.391 mg/L PBTK NA 95% Human Human +DTXSID7047726 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047726 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047726 Vd NA 1.024 L/kg 1compartment NA NA Rat Human DTXSID7047726 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047726 TK.Half.Life NA 1.229 hours 1compartment NA NA Rat Human -DTXSID7047726 Css NA 0.08564 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047726 Css NA 0.4894 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047726 Css NA 0.05608 mg/L PBTK NA 50% Rat Human -DTXSID7047726 Css NA 0.3064 mg/L PBTK NA 95% Rat Human -DTXSID7047772 Clint NA 7.121 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047772 Fup NA 0.1351 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047772 Vd NA 2.43 L/kg 1compartment NA NA Human Human +DTXSID7047726 TK.Half.Life NA 1.468 hours 1compartment NA NA Rat Human +DTXSID7047726 Css NA 0.0383 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047726 Css NA 0.2287 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047726 Css NA 0.0246 mg/L PBTK NA 50% Rat Human +DTXSID7047726 Css NA 0.1386 mg/L PBTK NA 95% Rat Human +DTXSID7047772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047772 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047772 Vd NA 1.666 L/kg 1compartment NA NA Human Human DTXSID7047772 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047772 TK.Half.Life NA 7.453 hours 1compartment NA NA Human Human -DTXSID7047772 Css NA 0.281 mg/L 3compartmentss NA 50% Human Human -DTXSID7047772 Css NA 2.484 mg/L 3compartmentss NA 95% Human Human -DTXSID7047772 Css NA 0.2642 mg/L PBTK NA 50% Human Human -DTXSID7047772 Css NA 1.852 mg/L PBTK NA 95% Human Human -DTXSID7047772 Clint NA 7.121 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047772 Fup NA 0.1351 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047772 Vd NA 2.418 L/kg 1compartment NA NA Rat Human +DTXSID7047772 TK.Half.Life NA 2.937 hours 1compartment NA NA Human Human +DTXSID7047772 Css NA 0.1387 mg/L 3compartmentss NA 50% Human Human +DTXSID7047772 Css NA 1.265 mg/L 3compartmentss NA 95% Human Human +DTXSID7047772 Css NA 0.1105 mg/L PBTK NA 50% Human Human +DTXSID7047772 Css NA 0.8634 mg/L PBTK NA 95% Human Human +DTXSID7047772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047772 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047772 Vd NA 1.647 L/kg 1compartment NA NA Rat Human DTXSID7047772 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047772 TK.Half.Life NA 4.563 hours 1compartment NA NA Rat Human -DTXSID7047772 Css NA 0.147 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047772 Css NA 1.058 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047772 Css NA 0.1336 mg/L PBTK NA 50% Rat Human -DTXSID7047772 Css NA 0.7178 mg/L PBTK NA 95% Rat Human -DTXSID7047774 Clint NA 70.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047774 Fup NA 0.1843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047774 Vd NA 1.657 L/kg 1compartment NA NA Human Human +DTXSID7047772 TK.Half.Life NA 1.708 hours 1compartment NA NA Rat Human +DTXSID7047772 Css NA 0.018 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047772 Css NA 0.1236 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047772 Css NA 0.01438 mg/L PBTK NA 50% Rat Human +DTXSID7047772 Css NA 0.08359 mg/L PBTK NA 95% Rat Human +DTXSID7047774 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047774 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047774 Vd NA 1.603 L/kg 1compartment NA NA Human Human DTXSID7047774 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047774 TK.Half.Life NA 1.725 hours 1compartment NA NA Human Human -DTXSID7047774 Css NA 0.03861 mg/L 3compartmentss NA 50% Human Human -DTXSID7047774 Css NA 0.2883 mg/L 3compartmentss NA 95% Human Human -DTXSID7047774 Css NA 0.02922 mg/L PBTK NA 50% Human Human -DTXSID7047774 Css NA 0.203 mg/L PBTK NA 95% Human Human -DTXSID7047774 Clint NA 70.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047774 Fup NA 0.1843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047774 Vd NA 1.462 L/kg 1compartment NA NA Rat Human +DTXSID7047774 TK.Half.Life NA 5.169 hours 1compartment NA NA Human Human +DTXSID7047774 Css NA 0.289 mg/L 3compartmentss NA 50% Human Human +DTXSID7047774 Css NA 1.733 mg/L 3compartmentss NA 95% Human Human +DTXSID7047774 Css NA 0.225 mg/L PBTK NA 50% Human Human +DTXSID7047774 Css NA 1.216 mg/L PBTK NA 95% Human Human +DTXSID7047774 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047774 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047774 Vd NA 1.456 L/kg 1compartment NA NA Rat Human DTXSID7047774 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047774 TK.Half.Life NA 0.7408 hours 1compartment NA NA Rat Human -DTXSID7047774 Css NA 0.02135 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047774 Css NA 0.1271 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047774 Css NA 0.01565 mg/L PBTK NA 50% Rat Human -DTXSID7047774 Css NA 0.086 mg/L PBTK NA 95% Rat Human -DTXSID7047776 Clint NA 49.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047776 Fup NA 0.5163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047776 Vd NA 5.466 L/kg 1compartment NA NA Human Human +DTXSID7047774 TK.Half.Life NA 2.584 hours 1compartment NA NA Rat Human +DTXSID7047774 Css NA 0.03349 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047774 Css NA 0.1501 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047774 Css NA 0.02629 mg/L PBTK NA 50% Rat Human +DTXSID7047774 Css NA 0.102 mg/L PBTK NA 95% Rat Human +DTXSID7047776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047776 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047776 Vd NA 1.364 L/kg 1compartment NA NA Human Human DTXSID7047776 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047776 TK.Half.Life NA 2.632 hours 1compartment NA NA Human Human -DTXSID7047776 Css NA 0.009112 mg/L 3compartmentss NA 50% Human Human -DTXSID7047776 Css NA 0.1064 mg/L 3compartmentss NA 95% Human Human -DTXSID7047776 Css NA 0.01337 mg/L PBTK NA 50% Human Human -DTXSID7047776 Css NA 0.1055 mg/L PBTK NA 95% Human Human -DTXSID7047776 Clint NA 49.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047776 Fup NA 0.5163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047776 Vd NA 5.639 L/kg 1compartment NA NA Rat Human +DTXSID7047776 TK.Half.Life NA 1.657 hours 1compartment NA NA Human Human +DTXSID7047776 Css NA 0.05897 mg/L 3compartmentss NA 50% Human Human +DTXSID7047776 Css NA 0.4577 mg/L 3compartmentss NA 95% Human Human +DTXSID7047776 Css NA 0.04574 mg/L PBTK NA 50% Human Human +DTXSID7047776 Css NA 0.3139 mg/L PBTK NA 95% Human Human +DTXSID7047776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047776 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047776 Vd NA 1.131 L/kg 1compartment NA NA Rat Human DTXSID7047776 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047776 TK.Half.Life NA 1.334 hours 1compartment NA NA Rat Human -DTXSID7047776 Css NA 0.004734 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047776 Css NA 0.04732 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047776 Css NA 0.007115 mg/L PBTK NA 50% Rat Human -DTXSID7047776 Css NA 0.04738 mg/L PBTK NA 95% Rat Human -DTXSID7047778 Clint NA 11.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047778 Fup NA 0.0775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047778 Vd NA 3.294 L/kg 1compartment NA NA Human Human -DTXSID7047778 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047778 TK.Half.Life NA 7.936 hours 1compartment NA NA Human Human -DTXSID7047778 Css NA 0.2164 mg/L 3compartmentss NA 50% Human Human -DTXSID7047778 Css NA 1.803 mg/L 3compartmentss NA 95% Human Human -DTXSID7047778 Css NA 0.1912 mg/L PBTK NA 50% Human Human -DTXSID7047778 Css NA 1.364 mg/L PBTK NA 95% Human Human -DTXSID7047778 Clint NA 11.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047778 Fup NA 0.0775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047778 Vd NA 3.035 L/kg 1compartment NA NA Rat Human -DTXSID7047778 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047778 TK.Half.Life NA 3.59 hours 1compartment NA NA Rat Human -DTXSID7047778 Css NA 0.1178 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047778 Css NA 0.7802 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047778 Css NA 0.1014 mg/L PBTK NA 50% Rat Human -DTXSID7047778 Css NA 0.5687 mg/L PBTK NA 95% Rat Human +DTXSID7047776 TK.Half.Life NA 0.6789 hours 1compartment NA NA Rat Human +DTXSID7047776 Css NA 0.007397 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047776 Css NA 0.04166 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047776 Css NA 0.005748 mg/L PBTK NA 50% Rat Human +DTXSID7047776 Css NA 0.02947 mg/L PBTK NA 95% Rat Human +DTXSID7047778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047778 Fup 0.0944 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047778 Vd NA 3.108 L/kg 1compartment NA NA Human Human +DTXSID7047778 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID7047778 TK.Half.Life NA 57.81 hours 1compartment NA NA Human Human +DTXSID7047778 Css NA 2.136 mg/L 3compartmentss NA 50% Human Human +DTXSID7047778 Css NA 14.33 mg/L 3compartmentss NA 95% Human Human +DTXSID7047778 Css NA 1.487 mg/L PBTK NA 50% Human Human +DTXSID7047778 Css NA 9.652 mg/L PBTK NA 95% Human Human +DTXSID7047778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047778 Fup 0.0944 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047778 Vd NA 2.331 L/kg 1compartment NA NA Rat Human +DTXSID7047778 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID7047778 TK.Half.Life NA 8.098 hours 1compartment NA NA Rat Human +DTXSID7047778 Css NA 0.2788 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047778 Css NA 1.599 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047778 Css NA 0.1928 mg/L PBTK NA 50% Rat Human +DTXSID7047778 Css NA 1.089 mg/L PBTK NA 95% Rat Human DTXSID7047801 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7047801 Fup NA 0.6623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047801 Vd NA 0.5967 L/kg 1compartment NA NA Human Human +DTXSID7047801 Vd NA 0.4409 L/kg 1compartment NA NA Human Human DTXSID7047801 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047801 TK.Half.Life NA 5.83 hours 1compartment NA NA Human Human -DTXSID7047801 Css NA 1.173 mg/L 3compartmentss NA 50% Human Human -DTXSID7047801 Css NA 7.552 mg/L 3compartmentss NA 95% Human Human -DTXSID7047801 Css NA 0.9168 mg/L PBTK NA 50% Human Human -DTXSID7047801 Css NA 4.696 mg/L PBTK NA 95% Human Human +DTXSID7047801 TK.Half.Life NA 4.308 hours 1compartment NA NA Human Human +DTXSID7047801 Css NA 1.053 mg/L 3compartmentss NA 50% Human Human +DTXSID7047801 Css NA 6.537 mg/L 3compartmentss NA 95% Human Human +DTXSID7047801 Css NA 0.7817 mg/L PBTK NA 50% Human Human +DTXSID7047801 Css NA 4.051 mg/L PBTK NA 95% Human Human DTXSID7047801 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7047801 Fup NA 0.6623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047801 Vd NA 0.6271 L/kg 1compartment NA NA Rat Human +DTXSID7047801 Vd NA 0.4766 L/kg 1compartment NA NA Rat Human DTXSID7047801 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047801 TK.Half.Life NA 2.088 hours 1compartment NA NA Rat Human -DTXSID7047801 Css NA 0.3057 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047801 Css NA 1.856 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047801 Css NA 0.2299 mg/L PBTK NA 50% Rat Human -DTXSID7047801 Css NA 1.085 mg/L PBTK NA 95% Rat Human -DTXSID7047803 Clint NA 14.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047803 Fup NA 0.421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047803 Vd NA 0.9251 L/kg 1compartment NA NA Human Human -DTXSID7047803 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047803 TK.Half.Life NA 1.14 hours 1compartment NA NA Human Human -DTXSID7047803 Css NA 0.0693 mg/L 3compartmentss NA 50% Human Human -DTXSID7047803 Css NA 0.5109 mg/L 3compartmentss NA 95% Human Human -DTXSID7047803 Css NA 0.05366 mg/L PBTK NA 50% Human Human -DTXSID7047803 Css NA 0.3568 mg/L PBTK NA 95% Human Human -DTXSID7047803 Clint NA 14.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047803 Fup NA 0.421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047803 Vd NA 0.9262 L/kg 1compartment NA NA Rat Human +DTXSID7047801 TK.Half.Life NA 1.587 hours 1compartment NA NA Rat Human +DTXSID7047801 Css NA 0.02058 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047801 Css NA 0.1503 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047801 Css NA 0.01444 mg/L PBTK NA 50% Rat Human +DTXSID7047801 Css NA 0.09348 mg/L PBTK NA 95% Rat Human +DTXSID7047803 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047803 Fup 0.373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047803 Vd NA 0.9868 L/kg 1compartment NA NA Human Human +DTXSID7047803 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7047803 TK.Half.Life NA 17.26 hours 1compartment NA NA Human Human +DTXSID7047803 Css NA 1.553 mg/L 3compartmentss NA 50% Human Human +DTXSID7047803 Css NA 7.07 mg/L 3compartmentss NA 95% Human Human +DTXSID7047803 Css NA 1.225 mg/L PBTK NA 50% Human Human +DTXSID7047803 Css NA 4.636 mg/L PBTK NA 95% Human Human +DTXSID7047803 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047803 Fup 0.373 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047803 Vd NA 0.9765 L/kg 1compartment NA NA Rat Human DTXSID7047803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047803 TK.Half.Life NA 0.6086 hours 1compartment NA NA Rat Human -DTXSID7047803 Css NA 0.03542 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047803 Css NA 0.2211 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047803 Css NA 0.0268 mg/L PBTK NA 50% Rat Human -DTXSID7047803 Css NA 0.1427 mg/L PBTK NA 95% Rat Human -DTXSID7047807 Clint NA 37.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047807 Fup NA 0.2138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047807 Vd NA 2.782 L/kg 1compartment NA NA Human Human +DTXSID7047803 TK.Half.Life NA 5.786 hours 1compartment NA NA Rat Human +DTXSID7047803 Css NA 0.03782 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047803 Css NA 0.2336 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047803 Css NA 0.02994 mg/L PBTK NA 50% Rat Human +DTXSID7047803 Css NA 0.1536 mg/L PBTK NA 95% Rat Human +DTXSID7047807 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047807 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047807 Vd NA 3.138 L/kg 1compartment NA NA Human Human DTXSID7047807 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047807 TK.Half.Life NA 2.548 hours 1compartment NA NA Human Human -DTXSID7047807 Css NA 0.03441 mg/L 3compartmentss NA 50% Human Human -DTXSID7047807 Css NA 0.292 mg/L 3compartmentss NA 95% Human Human -DTXSID7047807 Css NA 0.03566 mg/L PBTK NA 50% Human Human -DTXSID7047807 Css NA 0.2485 mg/L PBTK NA 95% Human Human -DTXSID7047807 Clint NA 37.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047807 Fup NA 0.2138 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047807 Vd NA 2.803 L/kg 1compartment NA NA Rat Human +DTXSID7047807 TK.Half.Life NA 5.373 hours 1compartment NA NA Human Human +DTXSID7047807 Css NA 0.09644 mg/L 3compartmentss NA 50% Human Human +DTXSID7047807 Css NA 0.8137 mg/L 3compartmentss NA 95% Human Human +DTXSID7047807 Css NA 0.1127 mg/L PBTK NA 50% Human Human +DTXSID7047807 Css NA 0.7096 mg/L PBTK NA 95% Human Human +DTXSID7047807 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047807 Fup 0.401 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047807 Vd NA 3.177 L/kg 1compartment NA NA Rat Human DTXSID7047807 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047807 TK.Half.Life NA 1.387 hours 1compartment NA NA Rat Human -DTXSID7047807 Css NA 0.01853 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047807 Css NA 0.1206 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047807 Css NA 0.01886 mg/L PBTK NA 50% Rat Human -DTXSID7047807 Css NA 0.1011 mg/L PBTK NA 95% Rat Human -DTXSID7047851 Clint NA 67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047851 Fup NA 0.114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047851 Vd NA 1.458 L/kg 1compartment NA NA Human Human +DTXSID7047807 TK.Half.Life NA 3.167 hours 1compartment NA NA Rat Human +DTXSID7047807 Css NA 0.01108 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047807 Css NA 0.06943 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047807 Css NA 0.01337 mg/L PBTK NA 50% Rat Human +DTXSID7047807 Css NA 0.05767 mg/L PBTK NA 95% Rat Human +DTXSID7047851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047851 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047851 Vd NA 0.4221 L/kg 1compartment NA NA Human Human DTXSID7047851 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047851 TK.Half.Life NA 2.046 hours 1compartment NA NA Human Human -DTXSID7047851 Css NA 0.09157 mg/L 3compartmentss NA 50% Human Human -DTXSID7047851 Css NA 0.7206 mg/L 3compartmentss NA 95% Human Human -DTXSID7047851 Css NA 0.06125 mg/L PBTK NA 50% Human Human -DTXSID7047851 Css NA 0.4527 mg/L PBTK NA 95% Human Human -DTXSID7047851 Clint NA 67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047851 Fup NA 0.114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047851 Vd NA 1.123 L/kg 1compartment NA NA Rat Human +DTXSID7047851 TK.Half.Life NA 0.6736 hours 1compartment NA NA Human Human +DTXSID7047851 Css NA 0.1014 mg/L 3compartmentss NA 50% Human Human +DTXSID7047851 Css NA 0.7015 mg/L 3compartmentss NA 95% Human Human +DTXSID7047851 Css NA 0.0674 mg/L PBTK NA 50% Human Human +DTXSID7047851 Css NA 0.4439 mg/L PBTK NA 95% Human Human +DTXSID7047851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047851 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047851 Vd NA 0.4184 L/kg 1compartment NA NA Rat Human DTXSID7047851 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047851 TK.Half.Life NA 0.7624 hours 1compartment NA NA Rat Human -DTXSID7047851 Css NA 0.05089 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047851 Css NA 0.3174 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047851 Css NA 0.03223 mg/L PBTK NA 50% Rat Human -DTXSID7047851 Css NA 0.1878 mg/L PBTK NA 95% Rat Human -DTXSID7047853 Clint NA 45.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047853 Fup NA 0.1078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047853 Vd NA 3.234 L/kg 1compartment NA NA Human Human -DTXSID7047853 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047853 TK.Half.Life NA 5.781 hours 1compartment NA NA Human Human -DTXSID7047853 Css NA 0.135 mg/L 3compartmentss NA 50% Human Human -DTXSID7047853 Css NA 1.008 mg/L 3compartmentss NA 95% Human Human -DTXSID7047853 Css NA 0.1061 mg/L PBTK NA 50% Human Human -DTXSID7047853 Css NA 0.7332 mg/L PBTK NA 95% Human Human -DTXSID7047853 Clint NA 45.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047853 Fup NA 0.1078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047853 Vd NA 2.72 L/kg 1compartment NA NA Rat Human -DTXSID7047853 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047853 TK.Half.Life NA 1.861 hours 1compartment NA NA Rat Human -DTXSID7047853 Css NA 0.07552 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047853 Css NA 0.4252 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047853 Css NA 0.05718 mg/L PBTK NA 50% Rat Human -DTXSID7047853 Css NA 0.3125 mg/L PBTK NA 95% Rat Human -DTXSID7047857 Clint NA 19.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047857 Fup NA 0.31 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047857 Vd NA 1.359 L/kg 1compartment NA NA Human Human -DTXSID7047857 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047857 TK.Half.Life NA 1.656 hours 1compartment NA NA Human Human -DTXSID7047857 Css NA 0.06383 mg/L 3compartmentss NA 50% Human Human -DTXSID7047857 Css NA 0.4816 mg/L 3compartmentss NA 95% Human Human -DTXSID7047857 Css NA 0.0547 mg/L PBTK NA 50% Human Human -DTXSID7047857 Css NA 0.3615 mg/L PBTK NA 95% Human Human -DTXSID7047857 Clint NA 19.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047857 Fup NA 0.31 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047857 Vd NA 1.338 L/kg 1compartment NA NA Rat Human +DTXSID7047851 TK.Half.Life NA 0.366 hours 1compartment NA NA Rat Human +DTXSID7047851 Css NA 0.01281 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047851 Css NA 0.06877 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047851 Css NA 0.008388 mg/L PBTK NA 50% Rat Human +DTXSID7047851 Css NA 0.04259 mg/L PBTK NA 95% Rat Human +DTXSID7047857 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047857 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7047857 Vd NA 0.6015 L/kg 1compartment NA NA Human Human +DTXSID7047857 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7047857 TK.Half.Life NA 9.925 hours 1compartment NA NA Human Human +DTXSID7047857 Css NA 1.58 mg/L 3compartmentss NA 50% Human Human +DTXSID7047857 Css NA 7.147 mg/L 3compartmentss NA 95% Human Human +DTXSID7047857 Css NA 1.166 mg/L PBTK NA 50% Human Human +DTXSID7047857 Css NA 4.535 mg/L PBTK NA 95% Human Human +DTXSID7047857 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047857 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7047857 Vd NA 0.5904 L/kg 1compartment NA NA Rat Human DTXSID7047857 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047857 TK.Half.Life NA 0.8935 hours 1compartment NA NA Rat Human -DTXSID7047857 Css NA 0.03422 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047857 Css NA 0.2059 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047857 Css NA 0.02823 mg/L PBTK NA 50% Rat Human -DTXSID7047857 Css NA 0.1477 mg/L PBTK NA 95% Rat Human +DTXSID7047857 TK.Half.Life NA 3.301 hours 1compartment NA NA Rat Human +DTXSID7047857 Css NA 0.03796 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047857 Css NA 0.2271 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047857 Css NA 0.02832 mg/L PBTK NA 50% Rat Human +DTXSID7047857 Css NA 0.1448 mg/L PBTK NA 95% Rat Human DTXSID7047859 Clint 9 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Human Human DTXSID7047859 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7047859 Vd NA 4.39 L/kg 1compartment NA NA Human Human +DTXSID7047859 Vd NA 4.736 L/kg 1compartment NA NA Human Human DTXSID7047859 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7047859 TK.Half.Life NA 12.82 hours 1compartment NA NA Human Human -DTXSID7047859 Css NA 0.3132 mg/L 3compartmentss NA 50% Human Human -DTXSID7047859 Css NA 1.897 mg/L 3compartmentss NA 95% Human Human -DTXSID7047859 Css NA 0.1981 mg/L PBTK NA 50% Human Human -DTXSID7047859 Css NA 1.171 mg/L PBTK NA 95% Human Human +DTXSID7047859 TK.Half.Life NA 10.4 hours 1compartment NA NA Human Human +DTXSID7047859 Css NA 0.1477 mg/L 3compartmentss NA 50% Human Human +DTXSID7047859 Css NA 0.9051 mg/L 3compartmentss NA 95% Human Human +DTXSID7047859 Css NA 0.1474 mg/L PBTK NA 50% Human Human +DTXSID7047859 Css NA 0.9045 mg/L PBTK NA 95% Human Human DTXSID7047859 Clint 9 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Rat Human DTXSID7047859 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7047859 Vd NA 3.823 L/kg 1compartment NA NA Rat Human +DTXSID7047859 Vd NA 4.257 L/kg 1compartment NA NA Rat Human DTXSID7047859 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047859 TK.Half.Life NA 2.858 hours 1compartment NA NA Rat Human -DTXSID7047859 Css NA 0.1863 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047859 Css NA 0.8797 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047859 Css NA 0.1109 mg/L PBTK NA 50% Rat Human -DTXSID7047859 Css NA 0.5148 mg/L PBTK NA 95% Rat Human -DTXSID7047930 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047930 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7047930 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID7047930 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7047930 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID7047930 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID7047930 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID7047930 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID7047930 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID7047930 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047930 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7047930 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID7047930 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7047930 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID7047930 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID7047930 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID7047930 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID7047930 Css NA 5.483 mg/L PBTK NA 95% Rat Human +DTXSID7047859 TK.Half.Life NA 2.745 hours 1compartment NA NA Rat Human +DTXSID7047859 Css NA 0.01747 mg/L 3compartmentss NA 50% Rat Human +DTXSID7047859 Css NA 0.07916 mg/L 3compartmentss NA 95% Rat Human +DTXSID7047859 Css NA 0.01809 mg/L PBTK NA 50% Rat Human +DTXSID7047859 Css NA 0.08188 mg/L PBTK NA 95% Rat Human DTXSID7048168 Clint 7.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID7048168 Fup 0.0309 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID7048168 Vd NA 1.353 L/kg 1compartment NA NA Human Human +DTXSID7048168 Vd NA 1.366 L/kg 1compartment NA NA Human Human DTXSID7048168 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7048168 TK.Half.Life NA 22.19 hours 1compartment NA NA Human Human -DTXSID7048168 Css NA 2.101 mg/L 3compartmentss NA 50% Human Human -DTXSID7048168 Css NA 13.76 mg/L 3compartmentss NA 95% Human Human -DTXSID7048168 Css NA 1.338 mg/L PBTK NA 50% Human Human -DTXSID7048168 Css NA 8.259 mg/L PBTK NA 95% Human Human +DTXSID7048168 TK.Half.Life NA 22.46 hours 1compartment NA NA Human Human +DTXSID7048168 Css NA 2.05 mg/L 3compartmentss NA 50% Human Human +DTXSID7048168 Css NA 13.27 mg/L 3compartmentss NA 95% Human Human +DTXSID7048168 Css NA 1.305 mg/L PBTK NA 50% Human Human +DTXSID7048168 Css NA 8.108 mg/L PBTK NA 95% Human Human DTXSID7048168 Clint 7.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID7048168 Fup 0.0309 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID7048168 Vd NA 1.022 L/kg 1compartment NA NA Rat Human +DTXSID7048168 Vd NA 1.031 L/kg 1compartment NA NA Rat Human DTXSID7048168 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7048168 TK.Half.Life NA 8.945 hours 1compartment NA NA Rat Human -DTXSID7048168 Css NA 1.137 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048168 Css NA 5.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048168 Css NA 0.6836 mg/L PBTK NA 50% Rat Human -DTXSID7048168 Css NA 3.1 mg/L PBTK NA 95% Rat Human +DTXSID7048168 TK.Half.Life NA 9.014 hours 1compartment NA NA Rat Human +DTXSID7048168 Css NA 0.2605 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048168 Css NA 1.255 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048168 Css NA 0.1616 mg/L PBTK NA 50% Rat Human +DTXSID7048168 Css NA 0.7412 mg/L PBTK NA 95% Rat Human +DTXSID7048249 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048249 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7048249 Vd NA 3.017 L/kg 1compartment NA NA Human Human +DTXSID7048249 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048249 TK.Half.Life NA 3.51 hours 1compartment NA NA Human Human +DTXSID7048249 Css NA 0.06076 mg/L 3compartmentss NA 50% Human Human +DTXSID7048249 Css NA 0.7583 mg/L 3compartmentss NA 95% Human Human +DTXSID7048249 Css NA 0.07864 mg/L PBTK NA 50% Human Human +DTXSID7048249 Css NA 0.6286 mg/L PBTK NA 95% Human Human +DTXSID7048249 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048249 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7048249 Vd NA 2.981 L/kg 1compartment NA NA Rat Human +DTXSID7048249 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048249 TK.Half.Life NA 1.975 hours 1compartment NA NA Rat Human +DTXSID7048249 Css NA 0.006704 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048249 Css NA 0.07399 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048249 Css NA 0.009113 mg/L PBTK NA 50% Rat Human +DTXSID7048249 Css NA 0.05677 mg/L PBTK NA 95% Rat Human DTXSID7048291 Clint NA 0.8242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7048291 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048291 Vd NA 0.2259 L/kg 1compartment NA NA Human Human -DTXSID7048291 Days.Css NA 31 Days PBTK NA NA Human Human -DTXSID7048291 TK.Half.Life NA 139.7 hours 1compartment NA NA Human Human -DTXSID7048291 Css NA 109.8 mg/L 3compartmentss NA 50% Human Human -DTXSID7048291 Css NA 679.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7048291 Css NA 64.32 mg/L PBTK NA 50% Human Human -DTXSID7048291 Css NA 393.5 mg/L PBTK NA 95% Human Human +DTXSID7048291 Vd NA 0.1805 L/kg 1compartment NA NA Human Human +DTXSID7048291 Days.Css NA 25 Days PBTK NA NA Human Human +DTXSID7048291 TK.Half.Life NA 114.6 hours 1compartment NA NA Human Human +DTXSID7048291 Css NA 93.7 mg/L 3compartmentss NA 50% Human Human +DTXSID7048291 Css NA 601.7 mg/L 3compartmentss NA 95% Human Human +DTXSID7048291 Css NA 54.92 mg/L PBTK NA 50% Human Human +DTXSID7048291 Css NA 346.7 mg/L PBTK NA 95% Human Human DTXSID7048291 Clint NA 0.8242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7048291 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048291 Vd NA 0.2102 L/kg 1compartment NA NA Rat Human -DTXSID7048291 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID7048291 TK.Half.Life NA 63.53 hours 1compartment NA NA Rat Human -DTXSID7048291 Css NA 44.37 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048291 Css NA 243.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048291 Css NA 24.34 mg/L PBTK NA 50% Rat Human -DTXSID7048291 Css NA 131.7 mg/L PBTK NA 95% Rat Human -DTXSID7048580 Clint NA 59.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7048291 Vd NA 0.1763 L/kg 1compartment NA NA Rat Human +DTXSID7048291 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID7048291 TK.Half.Life NA 54.28 hours 1compartment NA NA Rat Human +DTXSID7048291 Css NA 2.597 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048291 Css NA 21 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048291 Css NA 1.426 mg/L PBTK NA 50% Rat Human +DTXSID7048291 Css NA 11.67 mg/L PBTK NA 95% Rat Human +DTXSID7048295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048295 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7048295 Vd NA 0.5775 L/kg 1compartment NA NA Human Human +DTXSID7048295 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048295 TK.Half.Life NA 2.428 hours 1compartment NA NA Human Human +DTXSID7048295 Css NA 0.4796 mg/L 3compartmentss NA 50% Human Human +DTXSID7048295 Css NA 4.355 mg/L 3compartmentss NA 95% Human Human +DTXSID7048295 Css NA 0.3205 mg/L PBTK NA 50% Human Human +DTXSID7048295 Css NA 2.718 mg/L PBTK NA 95% Human Human +DTXSID7048295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048295 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7048295 Vd NA 0.5387 L/kg 1compartment NA NA Rat Human +DTXSID7048295 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048295 TK.Half.Life NA 1.421 hours 1compartment NA NA Rat Human +DTXSID7048295 Css NA 0.02309 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048295 Css NA 0.2407 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048295 Css NA 0.01499 mg/L PBTK NA 50% Rat Human +DTXSID7048295 Css NA 0.1442 mg/L PBTK NA 95% Rat Human +DTXSID7048320 Clint 11 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Human Human +DTXSID7048320 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048320 Vd NA 2.247 L/kg 1compartment NA NA Human Human +DTXSID7048320 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048320 TK.Half.Life NA 4.242 hours 1compartment NA NA Human Human +DTXSID7048320 Css NA 0.1282 mg/L 3compartmentss NA 50% Human Human +DTXSID7048320 Css NA 0.8939 mg/L 3compartmentss NA 95% Human Human +DTXSID7048320 Css NA 0.1134 mg/L PBTK NA 50% Human Human +DTXSID7048320 Css NA 0.6832 mg/L PBTK NA 95% Human Human +DTXSID7048320 Clint 11 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Rat Human +DTXSID7048320 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048320 Vd NA 2.133 L/kg 1compartment NA NA Rat Human +DTXSID7048320 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048320 TK.Half.Life NA 2.195 hours 1compartment NA NA Rat Human +DTXSID7048320 Css NA 0.01554 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048320 Css NA 0.08076 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048320 Css NA 0.01387 mg/L PBTK NA 50% Rat Human +DTXSID7048320 Css NA 0.06031 mg/L PBTK NA 95% Rat Human +DTXSID7048326 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048326 Fup 0.27 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7048326 Vd NA 0.4919 L/kg 1compartment NA NA Human Human +DTXSID7048326 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7048326 TK.Half.Life NA 11.84 hours 1compartment NA NA Human Human +DTXSID7048326 Css NA 2.418 mg/L 3compartmentss NA 50% Human Human +DTXSID7048326 Css NA 9.298 mg/L 3compartmentss NA 95% Human Human +DTXSID7048326 Css NA 1.676 mg/L PBTK NA 50% Human Human +DTXSID7048326 Css NA 5.832 mg/L PBTK NA 95% Human Human +DTXSID7048326 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048326 Fup 0.27 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7048326 Vd NA 0.4849 L/kg 1compartment NA NA Rat Human +DTXSID7048326 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048326 TK.Half.Life NA 3.963 hours 1compartment NA NA Rat Human +DTXSID7048326 Css NA 0.05836 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048326 Css NA 0.3328 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048326 Css NA 0.03977 mg/L PBTK NA 50% Rat Human +DTXSID7048326 Css NA 0.2043 mg/L PBTK NA 95% Rat Human +DTXSID7048370 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048370 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7048370 Vd NA 3.615 L/kg 1compartment NA NA Human Human +DTXSID7048370 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048370 TK.Half.Life NA 5.677 hours 1compartment NA NA Human Human +DTXSID7048370 Css NA 0.1007 mg/L 3compartmentss NA 50% Human Human +DTXSID7048370 Css NA 0.822 mg/L 3compartmentss NA 95% Human Human +DTXSID7048370 Css NA 0.09532 mg/L PBTK NA 50% Human Human +DTXSID7048370 Css NA 0.6876 mg/L PBTK NA 95% Human Human +DTXSID7048370 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048370 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7048370 Vd NA 3.34 L/kg 1compartment NA NA Rat Human +DTXSID7048370 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048370 TK.Half.Life NA 2.426 hours 1compartment NA NA Rat Human +DTXSID7048370 Css NA 0.01264 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048370 Css NA 0.08712 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048370 Css NA 0.01232 mg/L PBTK NA 50% Rat Human +DTXSID7048370 Css NA 0.07044 mg/L PBTK NA 95% Rat Human +DTXSID7048534 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048534 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7048534 Vd NA 5.185 L/kg 1compartment NA NA Human Human +DTXSID7048534 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048534 TK.Half.Life NA 5.608 hours 1compartment NA NA Human Human +DTXSID7048534 Css NA 0.04256 mg/L 3compartmentss NA 50% Human Human +DTXSID7048534 Css NA 0.5755 mg/L 3compartmentss NA 95% Human Human +DTXSID7048534 Css NA 0.06708 mg/L PBTK NA 50% Human Human +DTXSID7048534 Css NA 0.538 mg/L PBTK NA 95% Human Human +DTXSID7048534 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048534 Fup 0.64 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7048534 Vd NA 5.309 L/kg 1compartment NA NA Rat Human +DTXSID7048534 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048534 TK.Half.Life NA 3.285 hours 1compartment NA NA Rat Human +DTXSID7048534 Css NA 0.001834 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048534 Css NA 0.02887 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048534 Css NA 0.003083 mg/L PBTK NA 50% Rat Human +DTXSID7048534 Css NA 0.02705 mg/L PBTK NA 95% Rat Human +DTXSID7048536 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048536 Fup 0.46 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID7048536 Vd NA 2.836 L/kg 1compartment NA NA Human Human +DTXSID7048536 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048536 TK.Half.Life NA 4.784 hours 1compartment NA NA Human Human +DTXSID7048536 Css NA 0.1009 mg/L 3compartmentss NA 50% Human Human +DTXSID7048536 Css NA 0.8431 mg/L 3compartmentss NA 95% Human Human +DTXSID7048536 Css NA 0.1083 mg/L PBTK NA 50% Human Human +DTXSID7048536 Css NA 0.6888 mg/L PBTK NA 95% Human Human +DTXSID7048536 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048536 Fup 0.46 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID7048536 Vd NA 2.807 L/kg 1compartment NA NA Rat Human +DTXSID7048536 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048536 TK.Half.Life NA 2.592 hours 1compartment NA NA Rat Human +DTXSID7048536 Css NA 0.01152 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048536 Css NA 0.07325 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048536 Css NA 0.01261 mg/L PBTK NA 50% Rat Human +DTXSID7048536 Css NA 0.05659 mg/L PBTK NA 95% Rat Human +DTXSID7048580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7048580 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7048580 Vd NA 2.416 L/kg 1compartment NA NA Human Human -DTXSID7048580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048580 TK.Half.Life NA 1.142 hours 1compartment NA NA Human Human -DTXSID7048580 Css NA 0.006981 mg/L 3compartmentss NA 50% Human Human -DTXSID7048580 Css NA 0.1031 mg/L 3compartmentss NA 95% Human Human -DTXSID7048580 Css NA 0.007469 mg/L PBTK NA 50% Human Human -DTXSID7048580 Css NA 0.091 mg/L PBTK NA 95% Human Human -DTXSID7048580 Clint NA 59.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7048580 Vd NA 3.374 L/kg 1compartment NA NA Human Human +DTXSID7048580 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7048580 TK.Half.Life NA 21.86 hours 1compartment NA NA Human Human +DTXSID7048580 Css NA 0.5422 mg/L 3compartmentss NA 50% Human Human +DTXSID7048580 Css NA 4.93 mg/L 3compartmentss NA 95% Human Human +DTXSID7048580 Css NA 0.6742 mg/L PBTK NA 50% Human Human +DTXSID7048580 Css NA 3.688 mg/L PBTK NA 95% Human Human +DTXSID7048580 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7048580 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7048580 Vd NA 2.46 L/kg 1compartment NA NA Rat Human +DTXSID7048580 Vd NA 3.442 L/kg 1compartment NA NA Rat Human DTXSID7048580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048580 TK.Half.Life NA 0.5348 hours 1compartment NA NA Rat Human -DTXSID7048580 Css NA 0.003501 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048580 Css NA 0.04369 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048580 Css NA 0.003784 mg/L PBTK NA 50% Rat Human -DTXSID7048580 Css NA 0.03789 mg/L PBTK NA 95% Rat Human -DTXSID7048582 Clint NA 34.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048582 Fup NA 0.2636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048582 Vd NA 0.4271 L/kg 1compartment NA NA Human Human +DTXSID7048580 TK.Half.Life NA 7.591 hours 1compartment NA NA Rat Human +DTXSID7048580 Css NA 0.03041 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048580 Css NA 0.245 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048580 Css NA 0.03981 mg/L PBTK NA 50% Rat Human +DTXSID7048580 Css NA 0.178 mg/L PBTK NA 95% Rat Human +DTXSID7048582 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048582 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048582 Vd NA 0.5342 L/kg 1compartment NA NA Human Human DTXSID7048582 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048582 TK.Half.Life NA 0.5161 hours 1compartment NA NA Human Human -DTXSID7048582 Css NA 0.05421 mg/L 3compartmentss NA 50% Human Human -DTXSID7048582 Css NA 0.3965 mg/L 3compartmentss NA 95% Human Human -DTXSID7048582 Css NA 0.03649 mg/L PBTK NA 50% Human Human -DTXSID7048582 Css NA 0.2513 mg/L PBTK NA 95% Human Human -DTXSID7048582 Clint NA 34.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048582 Fup NA 0.2636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048582 Vd NA 0.409 L/kg 1compartment NA NA Rat Human +DTXSID7048582 TK.Half.Life NA 1.739 hours 1compartment NA NA Human Human +DTXSID7048582 Css NA 0.277 mg/L 3compartmentss NA 50% Human Human +DTXSID7048582 Css NA 1.756 mg/L 3compartmentss NA 95% Human Human +DTXSID7048582 Css NA 0.1861 mg/L PBTK NA 50% Human Human +DTXSID7048582 Css NA 1.11 mg/L PBTK NA 95% Human Human +DTXSID7048582 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048582 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048582 Vd NA 0.4801 L/kg 1compartment NA NA Rat Human DTXSID7048582 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048582 TK.Half.Life NA 0.2532 hours 1compartment NA NA Rat Human -DTXSID7048582 Css NA 0.02982 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048582 Css NA 0.1666 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048582 Css NA 0.01911 mg/L PBTK NA 50% Rat Human -DTXSID7048582 Css NA 0.1036 mg/L PBTK NA 95% Rat Human -DTXSID7048584 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048584 Fup NA 0.1034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048584 Vd NA 0.2404 L/kg 1compartment NA NA Human Human -DTXSID7048584 TK.Half.Life NA NA hours 1compartment NA NA Human Human -DTXSID7048584 Css NA NA mg/L 3compartmentss NA 50% Human Human -DTXSID7048584 Css NA NA mg/L 3compartmentss NA 95% Human Human -DTXSID7048584 Css NA NA mg/L PBTK NA 50% Human Human -DTXSID7048584 Css NA NA mg/L PBTK NA 95% Human Human -DTXSID7048584 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048584 Fup NA 0.1034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048584 Vd NA 0.252 L/kg 1compartment NA NA Rat Human -DTXSID7048584 TK.Half.Life NA NA hours 1compartment NA NA Rat Human -DTXSID7048584 Css NA NA mg/L 3compartmentss NA 50% Rat Human -DTXSID7048584 Css NA NA mg/L 3compartmentss NA 95% Rat Human -DTXSID7048584 Css NA NA mg/L PBTK NA 50% Rat Human -DTXSID7048584 Css NA NA mg/L PBTK NA 95% Rat Human -DTXSID7048586 Clint NA 4040 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048586 Fup NA 0.0176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048586 Vd NA 2.872 L/kg 1compartment NA NA Human Human +DTXSID7048582 TK.Half.Life NA 0.9025 hours 1compartment NA NA Rat Human +DTXSID7048582 Css NA 0.01263 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048582 Css NA 0.08317 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048582 Css NA 0.008328 mg/L PBTK NA 50% Rat Human +DTXSID7048582 Css NA 0.05092 mg/L PBTK NA 95% Rat Human +DTXSID7048586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048586 Fup 0.0381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048586 Vd NA 0.8879 L/kg 1compartment NA NA Human Human DTXSID7048586 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048586 TK.Half.Life NA 2.464 hours 1compartment NA NA Human Human -DTXSID7048586 Css NA 0.005834 mg/L 3compartmentss NA 50% Human Human -DTXSID7048586 Css NA 0.04218 mg/L 3compartmentss NA 95% Human Human -DTXSID7048586 Css NA 0.004003 mg/L PBTK NA 50% Human Human -DTXSID7048586 Css NA 0.02795 mg/L PBTK NA 95% Human Human -DTXSID7048586 Clint NA 4040 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048586 Fup NA 0.0176 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048586 Vd NA 2.185 L/kg 1compartment NA NA Rat Human +DTXSID7048586 TK.Half.Life NA 4.412 hours 1compartment NA NA Human Human +DTXSID7048586 Css NA 0.625 mg/L 3compartmentss NA 50% Human Human +DTXSID7048586 Css NA 6.386 mg/L 3compartmentss NA 95% Human Human +DTXSID7048586 Css NA 0.3968 mg/L PBTK NA 50% Human Human +DTXSID7048586 Css NA 3.825 mg/L PBTK NA 95% Human Human +DTXSID7048586 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048586 Fup 0.0381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048586 Vd NA 0.8071 L/kg 1compartment NA NA Rat Human DTXSID7048586 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048586 TK.Half.Life NA 0.8056 hours 1compartment NA NA Rat Human -DTXSID7048586 Css NA 0.003265 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048586 Css NA 0.02062 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048586 Css NA 0.002136 mg/L PBTK NA 50% Rat Human -DTXSID7048586 Css NA 0.0129 mg/L PBTK NA 95% Rat Human -DTXSID7048588 Clint NA 2.004 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048588 Fup NA 0.2263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048588 Vd NA 2.35 L/kg 1compartment NA NA Human Human -DTXSID7048588 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7048588 TK.Half.Life NA 25.01 hours 1compartment NA NA Human Human -DTXSID7048588 Css NA 1.118 mg/L 3compartmentss NA 50% Human Human -DTXSID7048588 Css NA 4.918 mg/L 3compartmentss NA 95% Human Human -DTXSID7048588 Css NA 0.8801 mg/L PBTK NA 50% Human Human -DTXSID7048588 Css NA 3.497 mg/L PBTK NA 95% Human Human -DTXSID7048588 Clint NA 2.004 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048588 Fup NA 0.2263 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048588 Vd NA 1.932 L/kg 1compartment NA NA Rat Human -DTXSID7048588 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7048588 TK.Half.Life NA 7.929 hours 1compartment NA NA Rat Human -DTXSID7048588 Css NA 0.5126 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048588 Css NA 1.641 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048588 Css NA 0.3873 mg/L PBTK NA 50% Rat Human -DTXSID7048588 Css NA 1.067 mg/L PBTK NA 95% Rat Human -DTXSID7048611 Clint NA 1.228 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048611 Fup NA 0.512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048611 Vd NA 2.301 L/kg 1compartment NA NA Human Human -DTXSID7048611 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7048611 TK.Half.Life NA 19.26 hours 1compartment NA NA Human Human -DTXSID7048611 Css NA 0.8724 mg/L 3compartmentss NA 50% Human Human -DTXSID7048611 Css NA 3.911 mg/L 3compartmentss NA 95% Human Human -DTXSID7048611 Css NA 0.6978 mg/L PBTK NA 50% Human Human -DTXSID7048611 Css NA 2.722 mg/L PBTK NA 95% Human Human -DTXSID7048611 Clint NA 1.228 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048611 Fup NA 0.512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048611 Vd NA 1.802 L/kg 1compartment NA NA Rat Human +DTXSID7048586 TK.Half.Life NA 2.505 hours 1compartment NA NA Rat Human +DTXSID7048586 Css NA 0.03113 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048586 Css NA 0.343 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048586 Css NA 0.01922 mg/L PBTK NA 50% Rat Human +DTXSID7048586 Css NA 0.1983 mg/L PBTK NA 95% Rat Human +DTXSID7048588 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048588 Fup 0.343 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048588 Vd NA 1.607 L/kg 1compartment NA NA Human Human +DTXSID7048588 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048588 TK.Half.Life NA 3.741 hours 1compartment NA NA Human Human +DTXSID7048588 Css NA 0.1829 mg/L 3compartmentss NA 50% Human Human +DTXSID7048588 Css NA 1.158 mg/L 3compartmentss NA 95% Human Human +DTXSID7048588 Css NA 0.1504 mg/L PBTK NA 50% Human Human +DTXSID7048588 Css NA 0.8336 mg/L PBTK NA 95% Human Human +DTXSID7048588 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048588 Fup 0.343 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048588 Vd NA 1.472 L/kg 1compartment NA NA Rat Human +DTXSID7048588 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048588 TK.Half.Life NA 1.85 hours 1compartment NA NA Rat Human +DTXSID7048588 Css NA 0.02122 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048588 Css NA 0.104 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048588 Css NA 0.01767 mg/L PBTK NA 50% Rat Human +DTXSID7048588 Css NA 0.07238 mg/L PBTK NA 95% Rat Human +DTXSID7048611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048611 Fup 0.037 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048611 Vd NA 1.582 L/kg 1compartment NA NA Human Human +DTXSID7048611 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048611 TK.Half.Life NA 9.461 hours 1compartment NA NA Human Human +DTXSID7048611 Css NA 0.8596 mg/L 3compartmentss NA 50% Human Human +DTXSID7048611 Css NA 6.94 mg/L 3compartmentss NA 95% Human Human +DTXSID7048611 Css NA 0.546 mg/L PBTK NA 50% Human Human +DTXSID7048611 Css NA 4.224 mg/L PBTK NA 95% Human Human +DTXSID7048611 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048611 Fup 0.037 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048611 Vd NA 1.179 L/kg 1compartment NA NA Rat Human DTXSID7048611 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048611 TK.Half.Life NA 4.77 hours 1compartment NA NA Rat Human -DTXSID7048611 Css NA 0.3634 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048611 Css NA 1.311 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048611 Css NA 0.2851 mg/L PBTK NA 50% Rat Human -DTXSID7048611 Css NA 0.842 mg/L PBTK NA 95% Rat Human +DTXSID7048611 TK.Half.Life NA 3.538 hours 1compartment NA NA Rat Human +DTXSID7048611 Css NA 0.1126 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048611 Css NA 0.7134 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048611 Css NA 0.06959 mg/L PBTK NA 50% Rat Human +DTXSID7048611 Css NA 0.4261 mg/L PBTK NA 95% Rat Human DTXSID7048613 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7048613 Fup NA 0.1283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048613 Vd NA 0.9142 L/kg 1compartment NA NA Human Human -DTXSID7048613 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID7048613 TK.Half.Life NA 46.12 hours 1compartment NA NA Human Human -DTXSID7048613 Css NA 7.016 mg/L 3compartmentss NA 50% Human Human -DTXSID7048613 Css NA 34.56 mg/L 3compartmentss NA 95% Human Human -DTXSID7048613 Css NA 4.738 mg/L PBTK NA 50% Human Human -DTXSID7048613 Css NA 20.72 mg/L PBTK NA 95% Human Human +DTXSID7048613 Vd NA 0.2151 L/kg 1compartment NA NA Human Human +DTXSID7048613 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7048613 TK.Half.Life NA 10.84 hours 1compartment NA NA Human Human +DTXSID7048613 Css NA 6.608 mg/L 3compartmentss NA 50% Human Human +DTXSID7048613 Css NA 31.08 mg/L 3compartmentss NA 95% Human Human +DTXSID7048613 Css NA 3.995 mg/L PBTK NA 50% Human Human +DTXSID7048613 Css NA 18.4 mg/L PBTK NA 95% Human Human DTXSID7048613 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7048613 Fup NA 0.1283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048613 Vd NA 0.9118 L/kg 1compartment NA NA Rat Human -DTXSID7048613 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7048613 TK.Half.Life NA 15.67 hours 1compartment NA NA Rat Human -DTXSID7048613 Css NA 1.956 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048613 Css NA 8.231 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048613 Css NA 1.252 mg/L PBTK NA 50% Rat Human -DTXSID7048613 Css NA 4.665 mg/L PBTK NA 95% Rat Human -DTXSID7048615 Clint NA 17.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048615 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048615 Vd NA 2.038 L/kg 1compartment NA NA Human Human -DTXSID7048615 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048615 TK.Half.Life NA 1.276 hours 1compartment NA NA Human Human -DTXSID7048615 Css NA 0.02411 mg/L 3compartmentss NA 50% Human Human -DTXSID7048615 Css NA 0.3026 mg/L 3compartmentss NA 95% Human Human -DTXSID7048615 Css NA 0.0247 mg/L PBTK NA 50% Human Human -DTXSID7048615 Css NA 0.2644 mg/L PBTK NA 95% Human Human -DTXSID7048615 Clint NA 17.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048615 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048615 Vd NA 2.081 L/kg 1compartment NA NA Rat Human -DTXSID7048615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048615 TK.Half.Life NA 0.649 hours 1compartment NA NA Rat Human -DTXSID7048615 Css NA 0.01186 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048615 Css NA 0.1191 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048615 Css NA 0.01226 mg/L PBTK NA 50% Rat Human -DTXSID7048615 Css NA 0.09394 mg/L PBTK NA 95% Rat Human +DTXSID7048613 Vd NA 0.2204 L/kg 1compartment NA NA Rat Human +DTXSID7048613 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048613 TK.Half.Life NA 3.788 hours 1compartment NA NA Rat Human +DTXSID7048613 Css NA 0.1216 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048613 Css NA 0.8221 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048613 Css NA 0.06982 mg/L PBTK NA 50% Rat Human +DTXSID7048613 Css NA 0.464 mg/L PBTK NA 95% Rat Human DTXSID7048617 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7048617 Fup NA 0.0928 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048617 Vd NA 2.868 L/kg 1compartment NA NA Human Human -DTXSID7048617 Days.Css NA 71 Days PBTK NA NA Human Human -DTXSID7048617 TK.Half.Life NA 319.9 hours 1compartment NA NA Human Human -DTXSID7048617 Css NA 12.73 mg/L 3compartmentss NA 50% Human Human -DTXSID7048617 Css NA 55.75 mg/L 3compartmentss NA 95% Human Human -DTXSID7048617 Css NA 10.32 mg/L PBTK NA 50% Human Human -DTXSID7048617 Css NA 36.85 mg/L PBTK NA 95% Human Human +DTXSID7048617 Vd NA 0.2294 L/kg 1compartment NA NA Human Human +DTXSID7048617 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7048617 TK.Half.Life NA 15.99 hours 1compartment NA NA Human Human +DTXSID7048617 Css NA 9.397 mg/L 3compartmentss NA 50% Human Human +DTXSID7048617 Css NA 43.59 mg/L 3compartmentss NA 95% Human Human +DTXSID7048617 Css NA 5.659 mg/L PBTK NA 50% Human Human +DTXSID7048617 Css NA 25.69 mg/L PBTK NA 95% Human Human DTXSID7048617 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7048617 Fup NA 0.0928 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048617 Vd NA 2.542 L/kg 1compartment NA NA Rat Human -DTXSID7048617 Days.Css NA 20 Days PBTK NA NA Rat Human -DTXSID7048617 TK.Half.Life NA 69.04 hours 1compartment NA NA Rat Human -DTXSID7048617 Css NA 3.465 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048617 Css NA 12.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048617 Css NA 2.714 mg/L PBTK NA 50% Rat Human -DTXSID7048617 Css NA 8.014 mg/L PBTK NA 95% Rat Human +DTXSID7048617 Vd NA 0.238 L/kg 1compartment NA NA Rat Human +DTXSID7048617 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048617 TK.Half.Life NA 5.654 hours 1compartment NA NA Rat Human +DTXSID7048617 Css NA 0.1762 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048617 Css NA 1.15 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048617 Css NA 0.1011 mg/L PBTK NA 50% Rat Human +DTXSID7048617 Css NA 0.6458 mg/L PBTK NA 95% Rat Human DTXSID7048619 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7048619 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7048619 Vd NA 2.446 L/kg 1compartment NA NA Human Human -DTXSID7048619 Days.Css NA 58 Days PBTK NA NA Human Human -DTXSID7048619 TK.Half.Life NA 265 hours 1compartment NA NA Human Human -DTXSID7048619 Css NA 13.34 mg/L 3compartmentss NA 50% Human Human -DTXSID7048619 Css NA 46.4 mg/L 3compartmentss NA 95% Human Human -DTXSID7048619 Css NA 9.59 mg/L PBTK NA 50% Human Human -DTXSID7048619 Css NA 29.7 mg/L PBTK NA 95% Human Human +DTXSID7048619 Vd NA 0.4719 L/kg 1compartment NA NA Human Human +DTXSID7048619 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7048619 TK.Half.Life NA 21.85 hours 1compartment NA NA Human Human +DTXSID7048619 Css NA 3.582 mg/L 3compartmentss NA 50% Human Human +DTXSID7048619 Css NA 17.4 mg/L 3compartmentss NA 95% Human Human +DTXSID7048619 Css NA 2.301 mg/L PBTK NA 50% Human Human +DTXSID7048619 Css NA 10.43 mg/L PBTK NA 95% Human Human DTXSID7048619 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7048619 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7048619 Vd NA 1.909 L/kg 1compartment NA NA Rat Human -DTXSID7048619 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID7048619 TK.Half.Life NA 39.72 hours 1compartment NA NA Rat Human -DTXSID7048619 Css NA 3.601 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048619 Css NA 10.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048619 Css NA 2.476 mg/L PBTK NA 50% Rat Human -DTXSID7048619 Css NA 6.252 mg/L PBTK NA 95% Rat Human -DTXSID7048661 Clint NA 2.437 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048661 Fup NA 0.1363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048661 Vd NA 2.006 L/kg 1compartment NA NA Human Human -DTXSID7048661 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7048661 TK.Half.Life NA 17.61 hours 1compartment NA NA Human Human -DTXSID7048661 Css NA 0.9862 mg/L 3compartmentss NA 50% Human Human -DTXSID7048661 Css NA 6.709 mg/L 3compartmentss NA 95% Human Human -DTXSID7048661 Css NA 0.8262 mg/L PBTK NA 50% Human Human -DTXSID7048661 Css NA 4.491 mg/L PBTK NA 95% Human Human -DTXSID7048661 Clint NA 2.437 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048661 Fup NA 0.1363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048661 Vd NA 2.006 L/kg 1compartment NA NA Rat Human -DTXSID7048661 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7048661 TK.Half.Life NA 10.11 hours 1compartment NA NA Rat Human -DTXSID7048661 Css NA 0.4752 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048661 Css NA 2.533 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048661 Css NA 0.3801 mg/L PBTK NA 50% Rat Human -DTXSID7048661 Css NA 1.59 mg/L PBTK NA 95% Rat Human -DTXSID7048663 Clint NA 16.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048663 Fup NA 0.0484 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048663 Vd NA 0.2452 L/kg 1compartment NA NA Human Human +DTXSID7048619 Vd NA 0.4632 L/kg 1compartment NA NA Rat Human +DTXSID7048619 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048619 TK.Half.Life NA 7.3 hours 1compartment NA NA Rat Human +DTXSID7048619 Css NA 0.01969 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048619 Css NA 0.09578 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048619 Css NA 0.01192 mg/L PBTK NA 50% Rat Human +DTXSID7048619 Css NA 0.05413 mg/L PBTK NA 95% Rat Human +DTXSID7048661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048661 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048661 Vd NA 2.082 L/kg 1compartment NA NA Human Human +DTXSID7048661 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048661 TK.Half.Life NA 3.473 hours 1compartment NA NA Human Human +DTXSID7048661 Css NA 0.1244 mg/L 3compartmentss NA 50% Human Human +DTXSID7048661 Css NA 1.157 mg/L 3compartmentss NA 95% Human Human +DTXSID7048661 Css NA 0.1043 mg/L PBTK NA 50% Human Human +DTXSID7048661 Css NA 0.8194 mg/L PBTK NA 95% Human Human +DTXSID7048661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048661 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048661 Vd NA 2.084 L/kg 1compartment NA NA Rat Human +DTXSID7048661 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048661 TK.Half.Life NA 2.031 hours 1compartment NA NA Rat Human +DTXSID7048661 Css NA 0.01566 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048661 Css NA 0.1137 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048661 Css NA 0.01324 mg/L PBTK NA 50% Rat Human +DTXSID7048661 Css NA 0.07892 mg/L PBTK NA 95% Rat Human +DTXSID7048663 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048663 Fup 0.0425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048663 Vd NA 0.2902 L/kg 1compartment NA NA Human Human DTXSID7048663 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048663 TK.Half.Life NA 1.344 hours 1compartment NA NA Human Human -DTXSID7048663 Css NA 0.8464 mg/L 3compartmentss NA 50% Human Human -DTXSID7048663 Css NA 7.24 mg/L 3compartmentss NA 95% Human Human -DTXSID7048663 Css NA 0.5064 mg/L PBTK NA 50% Human Human -DTXSID7048663 Css NA 4.31 mg/L PBTK NA 95% Human Human -DTXSID7048663 Clint NA 16.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048663 Fup NA 0.0484 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048663 Vd NA 0.2324 L/kg 1compartment NA NA Rat Human +DTXSID7048663 TK.Half.Life NA 4.051 hours 1compartment NA NA Human Human +DTXSID7048663 Css NA 1.319 mg/L 3compartmentss NA 50% Human Human +DTXSID7048663 Css NA 11.58 mg/L 3compartmentss NA 95% Human Human +DTXSID7048663 Css NA 0.7933 mg/L PBTK NA 50% Human Human +DTXSID7048663 Css NA 6.757 mg/L PBTK NA 95% Human Human +DTXSID7048663 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048663 Fup 0.0425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048663 Vd NA 0.2617 L/kg 1compartment NA NA Rat Human DTXSID7048663 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048663 TK.Half.Life NA 0.8063 hours 1compartment NA NA Rat Human -DTXSID7048663 Css NA 0.4791 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048663 Css NA 2.937 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048663 Css NA 0.2679 mg/L PBTK NA 50% Rat Human -DTXSID7048663 Css NA 1.606 mg/L PBTK NA 95% Rat Human +DTXSID7048663 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human +DTXSID7048663 Css NA 0.01364 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048663 Css NA 0.1005 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048663 Css NA 0.00767 mg/L PBTK NA 50% Rat Human +DTXSID7048663 Css NA 0.05494 mg/L PBTK NA 95% Rat Human DTXSID7048665 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7048665 Fup NA 0.1389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048665 Vd NA 0.2844 L/kg 1compartment NA NA Human Human -DTXSID7048665 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7048665 TK.Half.Life NA 13.25 hours 1compartment NA NA Human Human -DTXSID7048665 Css NA 6.978 mg/L 3compartmentss NA 50% Human Human -DTXSID7048665 Css NA 30.93 mg/L 3compartmentss NA 95% Human Human -DTXSID7048665 Css NA 4.347 mg/L PBTK NA 50% Human Human -DTXSID7048665 Css NA 18.27 mg/L PBTK NA 95% Human Human +DTXSID7048665 Vd NA 0.5333 L/kg 1compartment NA NA Human Human +DTXSID7048665 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7048665 TK.Half.Life NA 24.86 hours 1compartment NA NA Human Human +DTXSID7048665 Css NA 6.525 mg/L 3compartmentss NA 50% Human Human +DTXSID7048665 Css NA 29.84 mg/L 3compartmentss NA 95% Human Human +DTXSID7048665 Css NA 4.221 mg/L PBTK NA 50% Human Human +DTXSID7048665 Css NA 17.83 mg/L PBTK NA 95% Human Human DTXSID7048665 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7048665 Fup NA 0.1389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048665 Vd NA 0.293 L/kg 1compartment NA NA Rat Human +DTXSID7048665 Vd NA 0.5309 L/kg 1compartment NA NA Rat Human DTXSID7048665 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048665 TK.Half.Life NA 4.652 hours 1compartment NA NA Rat Human -DTXSID7048665 Css NA 1.949 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048665 Css NA 7.485 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048665 Css NA 1.139 mg/L PBTK NA 50% Rat Human -DTXSID7048665 Css NA 4.133 mg/L PBTK NA 95% Rat Human -DTXSID7048667 Clint NA 22.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7048665 TK.Half.Life NA 8.426 hours 1compartment NA NA Rat Human +DTXSID7048665 Css NA 0.424 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048665 Css NA 1.64 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048665 Css NA 0.267 mg/L PBTK NA 50% Rat Human +DTXSID7048665 Css NA 0.9498 mg/L PBTK NA 95% Rat Human +DTXSID7048667 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7048667 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7048667 Vd NA 2.344 L/kg 1compartment NA NA Human Human +DTXSID7048667 Vd NA 2.956 L/kg 1compartment NA NA Human Human DTXSID7048667 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048667 TK.Half.Life NA 1.792 hours 1compartment NA NA Human Human -DTXSID7048667 Css NA 0.02728 mg/L 3compartmentss NA 50% Human Human -DTXSID7048667 Css NA 0.2835 mg/L 3compartmentss NA 95% Human Human -DTXSID7048667 Css NA 0.03756 mg/L PBTK NA 50% Human Human -DTXSID7048667 Css NA 0.2743 mg/L PBTK NA 95% Human Human -DTXSID7048667 Clint NA 22.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7048667 TK.Half.Life NA 3.075 hours 1compartment NA NA Human Human +DTXSID7048667 Css NA 0.03715 mg/L 3compartmentss NA 50% Human Human +DTXSID7048667 Css NA 0.3305 mg/L 3compartmentss NA 95% Human Human +DTXSID7048667 Css NA 0.04874 mg/L PBTK NA 50% Human Human +DTXSID7048667 Css NA 0.344 mg/L PBTK NA 95% Human Human +DTXSID7048667 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7048667 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7048667 Vd NA 2.148 L/kg 1compartment NA NA Rat Human +DTXSID7048667 Vd NA 2.549 L/kg 1compartment NA NA Rat Human DTXSID7048667 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048667 TK.Half.Life NA 0.8114 hours 1compartment NA NA Rat Human -DTXSID7048667 Css NA 0.01378 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048667 Css NA 0.1148 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048667 Css NA 0.01937 mg/L PBTK NA 50% Rat Human -DTXSID7048667 Css NA 0.1122 mg/L PBTK NA 95% Rat Human -DTXSID7048669 Clint NA 15.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048669 Fup NA 0.1143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048669 Vd NA 1.75 L/kg 1compartment NA NA Human Human +DTXSID7048667 TK.Half.Life NA 1.082 hours 1compartment NA NA Rat Human +DTXSID7048667 Css NA 0.001698 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048667 Css NA 0.01635 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048667 Css NA 0.00234 mg/L PBTK NA 50% Rat Human +DTXSID7048667 Css NA 0.01712 mg/L PBTK NA 95% Rat Human +DTXSID7048669 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048669 Fup 0.283 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048669 Vd NA 1.192 L/kg 1compartment NA NA Human Human DTXSID7048669 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048669 TK.Half.Life NA 6.112 hours 1compartment NA NA Human Human -DTXSID7048669 Css NA 0.4128 mg/L 3compartmentss NA 50% Human Human -DTXSID7048669 Css NA 2.868 mg/L 3compartmentss NA 95% Human Human -DTXSID7048669 Css NA 0.2801 mg/L PBTK NA 50% Human Human -DTXSID7048669 Css NA 1.828 mg/L PBTK NA 95% Human Human -DTXSID7048669 Clint NA 15.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048669 Fup NA 0.1143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048669 Vd NA 1.335 L/kg 1compartment NA NA Rat Human +DTXSID7048669 TK.Half.Life NA 3.36 hours 1compartment NA NA Human Human +DTXSID7048669 Css NA 0.247 mg/L 3compartmentss NA 50% Human Human +DTXSID7048669 Css NA 1.569 mg/L 3compartmentss NA 95% Human Human +DTXSID7048669 Css NA 0.1836 mg/L PBTK NA 50% Human Human +DTXSID7048669 Css NA 1.073 mg/L PBTK NA 95% Human Human +DTXSID7048669 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048669 Fup 0.283 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048669 Vd NA 0.9904 L/kg 1compartment NA NA Rat Human DTXSID7048669 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048669 TK.Half.Life NA 2.212 hours 1compartment NA NA Rat Human -DTXSID7048669 Css NA 0.2229 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048669 Css NA 1.18 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048669 Css NA 0.1437 mg/L PBTK NA 50% Rat Human -DTXSID7048669 Css NA 0.7027 mg/L PBTK NA 95% Rat Human +DTXSID7048669 TK.Half.Life NA 1.488 hours 1compartment NA NA Rat Human +DTXSID7048669 Css NA 0.02966 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048669 Css NA 0.134 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048669 Css NA 0.02194 mg/L PBTK NA 50% Rat Human +DTXSID7048669 Css NA 0.0872 mg/L PBTK NA 95% Rat Human DTXSID7048740 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7048740 Fup NA 0.7771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048740 Vd NA 0.5909 L/kg 1compartment NA NA Human Human +DTXSID7048740 Vd NA 0.5846 L/kg 1compartment NA NA Human Human DTXSID7048740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048740 TK.Half.Life NA 4.919 hours 1compartment NA NA Human Human -DTXSID7048740 Css NA 1.048 mg/L 3compartmentss NA 50% Human Human -DTXSID7048740 Css NA 6.143 mg/L 3compartmentss NA 95% Human Human -DTXSID7048740 Css NA 0.827 mg/L PBTK NA 50% Human Human -DTXSID7048740 Css NA 3.941 mg/L PBTK NA 95% Human Human +DTXSID7048740 TK.Half.Life NA 4.868 hours 1compartment NA NA Human Human +DTXSID7048740 Css NA 0.905 mg/L 3compartmentss NA 50% Human Human +DTXSID7048740 Css NA 5.293 mg/L 3compartmentss NA 95% Human Human +DTXSID7048740 Css NA 0.7145 mg/L PBTK NA 50% Human Human +DTXSID7048740 Css NA 3.36 mg/L PBTK NA 95% Human Human DTXSID7048740 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7048740 Fup NA 0.7771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048740 Vd NA 0.6347 L/kg 1compartment NA NA Rat Human +DTXSID7048740 Vd NA 0.6297 L/kg 1compartment NA NA Rat Human DTXSID7048740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048740 TK.Half.Life NA 1.801 hours 1compartment NA NA Rat Human -DTXSID7048740 Css NA 0.2714 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048740 Css NA 1.686 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048740 Css NA 0.2065 mg/L PBTK NA 50% Rat Human -DTXSID7048740 Css NA 0.9883 mg/L PBTK NA 95% Rat Human -DTXSID7048742 Clint NA 2.848 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048742 Fup NA 0.1402 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048742 Vd NA 0.4961 L/kg 1compartment NA NA Human Human +DTXSID7048740 TK.Half.Life NA 1.786 hours 1compartment NA NA Rat Human +DTXSID7048740 Css NA 0.01677 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048740 Css NA 0.1298 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048740 Css NA 0.01268 mg/L PBTK NA 50% Rat Human +DTXSID7048740 Css NA 0.08273 mg/L PBTK NA 95% Rat Human +DTXSID7048742 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048742 Fup 0.0856 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048742 Vd NA 1.264 L/kg 1compartment NA NA Human Human DTXSID7048742 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048742 TK.Half.Life NA 4.287 hours 1compartment NA NA Human Human -DTXSID7048742 Css NA 1.242 mg/L 3compartmentss NA 50% Human Human -DTXSID7048742 Css NA 7.092 mg/L 3compartmentss NA 95% Human Human -DTXSID7048742 Css NA 0.8 mg/L PBTK NA 50% Human Human -DTXSID7048742 Css NA 4.314 mg/L PBTK NA 95% Human Human -DTXSID7048742 Clint NA 2.848 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048742 Fup NA 0.1402 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048742 Vd NA 0.4433 L/kg 1compartment NA NA Rat Human +DTXSID7048742 TK.Half.Life NA 3.847 hours 1compartment NA NA Human Human +DTXSID7048742 Css NA 0.3483 mg/L 3compartmentss NA 50% Human Human +DTXSID7048742 Css NA 2.7 mg/L 3compartmentss NA 95% Human Human +DTXSID7048742 Css NA 0.2248 mg/L PBTK NA 50% Human Human +DTXSID7048742 Css NA 1.654 mg/L PBTK NA 95% Human Human +DTXSID7048742 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048742 Fup 0.0856 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048742 Vd NA 0.9671 L/kg 1compartment NA NA Rat Human DTXSID7048742 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048742 TK.Half.Life NA 2.175 hours 1compartment NA NA Rat Human -DTXSID7048742 Css NA 0.597 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048742 Css NA 2.712 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048742 Css NA 0.3607 mg/L PBTK NA 50% Rat Human -DTXSID7048742 Css NA 1.521 mg/L PBTK NA 95% Rat Human -DTXSID7048746 Clint NA 17.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048746 Fup NA 0.0059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048746 Vd NA 0.2924 L/kg 1compartment NA NA Human Human -DTXSID7048746 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7048746 TK.Half.Life NA 10.15 hours 1compartment NA NA Human Human -DTXSID7048746 Css NA 6.632 mg/L 3compartmentss NA 50% Human Human -DTXSID7048746 Css NA 60.61 mg/L 3compartmentss NA 95% Human Human -DTXSID7048746 Css NA 3.894 mg/L PBTK NA 50% Human Human -DTXSID7048746 Css NA 34.76 mg/L PBTK NA 95% Human Human -DTXSID7048746 Clint NA 17.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048746 Fup NA 0.0059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048746 Vd NA 0.2397 L/kg 1compartment NA NA Rat Human +DTXSID7048742 TK.Half.Life NA 1.571 hours 1compartment NA NA Rat Human +DTXSID7048742 Css NA 0.04538 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048742 Css NA 0.2701 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048742 Css NA 0.02879 mg/L PBTK NA 50% Rat Human +DTXSID7048742 Css NA 0.1651 mg/L PBTK NA 95% Rat Human +DTXSID7048746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048746 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048746 Vd NA 0.3096 L/kg 1compartment NA NA Human Human +DTXSID7048746 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048746 TK.Half.Life NA 0.9043 hours 1compartment NA NA Human Human +DTXSID7048746 Css NA 0.1829 mg/L 3compartmentss NA 50% Human Human +DTXSID7048746 Css NA 1.699 mg/L 3compartmentss NA 95% Human Human +DTXSID7048746 Css NA 0.1104 mg/L PBTK NA 50% Human Human +DTXSID7048746 Css NA 1.007 mg/L PBTK NA 95% Human Human +DTXSID7048746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048746 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048746 Vd NA 0.2856 L/kg 1compartment NA NA Rat Human DTXSID7048746 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048746 TK.Half.Life NA 5.559 hours 1compartment NA NA Rat Human -DTXSID7048746 Css NA 3.667 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048746 Css NA 28.85 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048746 Css NA 2 mg/L PBTK NA 50% Rat Human -DTXSID7048746 Css NA 15.68 mg/L PBTK NA 95% Rat Human -DTXSID7048748 Clint NA 39.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048748 Fup NA 0.8903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048748 Vd NA 3.404 L/kg 1compartment NA NA Human Human +DTXSID7048746 TK.Half.Life NA 0.5008 hours 1compartment NA NA Rat Human +DTXSID7048746 Css NA 0.001934 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048746 Css NA 0.01597 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048746 Css NA 0.001106 mg/L PBTK NA 50% Rat Human +DTXSID7048746 Css NA 0.008996 mg/L PBTK NA 95% Rat Human +DTXSID7048748 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048748 Fup 0.66 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048748 Vd NA 1.058 L/kg 1compartment NA NA Human Human DTXSID7048748 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048748 TK.Half.Life NA 1.612 hours 1compartment NA NA Human Human -DTXSID7048748 Css NA 0.01058 mg/L 3compartmentss NA 50% Human Human -DTXSID7048748 Css NA 0.1217 mg/L 3compartmentss NA 95% Human Human -DTXSID7048748 Css NA 0.01242 mg/L PBTK NA 50% Human Human -DTXSID7048748 Css NA 0.1044 mg/L PBTK NA 95% Human Human -DTXSID7048748 Clint NA 39.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048748 Fup NA 0.8903 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048748 Vd NA 3.473 L/kg 1compartment NA NA Rat Human +DTXSID7048748 TK.Half.Life NA 1.374 hours 1compartment NA NA Human Human +DTXSID7048748 Css NA 0.08928 mg/L 3compartmentss NA 50% Human Human +DTXSID7048748 Css NA 0.839 mg/L 3compartmentss NA 95% Human Human +DTXSID7048748 Css NA 0.07701 mg/L PBTK NA 50% Human Human +DTXSID7048748 Css NA 0.576 mg/L PBTK NA 95% Human Human +DTXSID7048748 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048748 Fup 0.66 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048748 Vd NA 1.107 L/kg 1compartment NA NA Rat Human DTXSID7048748 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048748 TK.Half.Life NA 0.7919 hours 1compartment NA NA Rat Human -DTXSID7048748 Css NA 0.005112 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048748 Css NA 0.05299 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048748 Css NA 0.00629 mg/L PBTK NA 50% Rat Human -DTXSID7048748 Css NA 0.04718 mg/L PBTK NA 95% Rat Human -DTXSID7048790 Clint NA 27.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048790 Fup NA 0.0274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048790 Vd NA 2.934 L/kg 1compartment NA NA Human Human -DTXSID7048790 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7048790 TK.Half.Life NA 34.99 hours 1compartment NA NA Human Human -DTXSID7048790 Css NA 1.522 mg/L 3compartmentss NA 50% Human Human -DTXSID7048790 Css NA 10.21 mg/L 3compartmentss NA 95% Human Human -DTXSID7048790 Css NA 1.047 mg/L PBTK NA 50% Human Human -DTXSID7048790 Css NA 6.754 mg/L PBTK NA 95% Human Human -DTXSID7048790 Clint NA 27.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048790 Fup NA 0.0274 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048790 Vd NA 2.21 L/kg 1compartment NA NA Rat Human -DTXSID7048790 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7048790 TK.Half.Life NA 6.466 hours 1compartment NA NA Rat Human -DTXSID7048790 Css NA 0.8484 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048790 Css NA 4.726 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048790 Css NA 0.5544 mg/L PBTK NA 50% Rat Human -DTXSID7048790 Css NA 2.957 mg/L PBTK NA 95% Rat Human -DTXSID7048792 Clint NA 85.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048792 Fup NA 0.2977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048792 Vd NA 0.6704 L/kg 1compartment NA NA Human Human +DTXSID7048748 TK.Half.Life NA 0.7767 hours 1compartment NA NA Rat Human +DTXSID7048748 Css NA 0.00997 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048748 Css NA 0.08078 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048748 Css NA 0.008787 mg/L PBTK NA 50% Rat Human +DTXSID7048748 Css NA 0.05291 mg/L PBTK NA 95% Rat Human +DTXSID7048790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048790 Fup 0.062 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048790 Vd NA 3.072 L/kg 1compartment NA NA Human Human +DTXSID7048790 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID7048790 TK.Half.Life NA 42.47 hours 1compartment NA NA Human Human +DTXSID7048790 Css NA 1.625 mg/L 3compartmentss NA 50% Human Human +DTXSID7048790 Css NA 10.31 mg/L 3compartmentss NA 95% Human Human +DTXSID7048790 Css NA 1.136 mg/L PBTK NA 50% Human Human +DTXSID7048790 Css NA 7.03 mg/L PBTK NA 95% Human Human +DTXSID7048790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048790 Fup 0.062 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048790 Vd NA 2.32 L/kg 1compartment NA NA Rat Human +DTXSID7048790 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID7048790 TK.Half.Life NA 6.776 hours 1compartment NA NA Rat Human +DTXSID7048790 Css NA 0.209 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048790 Css NA 1.189 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048790 Css NA 0.1447 mg/L PBTK NA 50% Rat Human +DTXSID7048790 Css NA 0.7764 mg/L PBTK NA 95% Rat Human +DTXSID7048792 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048792 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048792 Vd NA 0.6575 L/kg 1compartment NA NA Human Human DTXSID7048792 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048792 TK.Half.Life NA 0.607 hours 1compartment NA NA Human Human -DTXSID7048792 Css NA 0.01892 mg/L 3compartmentss NA 50% Human Human -DTXSID7048792 Css NA 0.1534 mg/L 3compartmentss NA 95% Human Human -DTXSID7048792 Css NA 0.01354 mg/L PBTK NA 50% Human Human -DTXSID7048792 Css NA 0.09965 mg/L PBTK NA 95% Human Human -DTXSID7048792 Clint NA 85.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048792 Fup NA 0.2977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048792 Vd NA 0.6229 L/kg 1compartment NA NA Rat Human +DTXSID7048792 TK.Half.Life NA 1.463 hours 1compartment NA NA Human Human +DTXSID7048792 Css NA 0.183 mg/L 3compartmentss NA 50% Human Human +DTXSID7048792 Css NA 1.216 mg/L 3compartmentss NA 95% Human Human +DTXSID7048792 Css NA 0.1343 mg/L PBTK NA 50% Human Human +DTXSID7048792 Css NA 0.8068 mg/L PBTK NA 95% Human Human +DTXSID7048792 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048792 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048792 Vd NA 0.6282 L/kg 1compartment NA NA Rat Human DTXSID7048792 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048792 TK.Half.Life NA 0.2662 hours 1compartment NA NA Rat Human -DTXSID7048792 Css NA 0.01046 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048792 Css NA 0.06554 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048792 Css NA 0.007132 mg/L PBTK NA 50% Rat Human -DTXSID7048792 Css NA 0.04083 mg/L PBTK NA 95% Rat Human -DTXSID7048794 Clint NA 12.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048794 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048794 Vd NA 1.276 L/kg 1compartment NA NA Human Human -DTXSID7048794 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7048794 TK.Half.Life NA 13.16 hours 1compartment NA NA Human Human -DTXSID7048794 Css NA 1.704 mg/L 3compartmentss NA 50% Human Human -DTXSID7048794 Css NA 13.5 mg/L 3compartmentss NA 95% Human Human -DTXSID7048794 Css NA 1.06 mg/L PBTK NA 50% Human Human -DTXSID7048794 Css NA 8.168 mg/L PBTK NA 95% Human Human -DTXSID7048794 Clint NA 12.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048794 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048794 Vd NA 0.9538 L/kg 1compartment NA NA Rat Human +DTXSID7048792 TK.Half.Life NA 0.7838 hours 1compartment NA NA Rat Human +DTXSID7048792 Css NA 0.0215 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048792 Css NA 0.1035 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048792 Css NA 0.01566 mg/L PBTK NA 50% Rat Human +DTXSID7048792 Css NA 0.06617 mg/L PBTK NA 95% Rat Human +DTXSID7048794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048794 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048794 Vd NA 1.995 L/kg 1compartment NA NA Human Human +DTXSID7048794 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048794 TK.Half.Life NA 6.33 hours 1compartment NA NA Human Human +DTXSID7048794 Css NA 0.3438 mg/L 3compartmentss NA 50% Human Human +DTXSID7048794 Css NA 2.427 mg/L 3compartmentss NA 95% Human Human +DTXSID7048794 Css NA 0.2331 mg/L PBTK NA 50% Human Human +DTXSID7048794 Css NA 1.562 mg/L PBTK NA 95% Human Human +DTXSID7048794 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048794 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048794 Vd NA 1.513 L/kg 1compartment NA NA Rat Human DTXSID7048794 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048794 TK.Half.Life NA 5.39 hours 1compartment NA NA Rat Human -DTXSID7048794 Css NA 0.9416 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048794 Css NA 6.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048794 Css NA 0.5497 mg/L PBTK NA 50% Rat Human -DTXSID7048794 Css NA 3.394 mg/L PBTK NA 95% Rat Human -DTXSID7048796 Clint NA 7.233 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048796 Fup NA 0.0252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048796 Vd NA 1.366 L/kg 1compartment NA NA Human Human -DTXSID7048796 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7048796 TK.Half.Life NA 27.84 hours 1compartment NA NA Human Human -DTXSID7048796 Css NA 3.447 mg/L 3compartmentss NA 50% Human Human -DTXSID7048796 Css NA 26.27 mg/L 3compartmentss NA 95% Human Human -DTXSID7048796 Css NA 2.15 mg/L PBTK NA 50% Human Human -DTXSID7048796 Css NA 15.92 mg/L PBTK NA 95% Human Human -DTXSID7048796 Clint NA 7.233 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048796 Fup NA 0.0252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048796 Vd NA 1.014 L/kg 1compartment NA NA Rat Human -DTXSID7048796 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7048796 TK.Half.Life NA 10.85 hours 1compartment NA NA Rat Human -DTXSID7048796 Css NA 1.842 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048796 Css NA 10.98 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048796 Css NA 1.077 mg/L PBTK NA 50% Rat Human -DTXSID7048796 Css NA 6.127 mg/L PBTK NA 95% Rat Human +DTXSID7048794 TK.Half.Life NA 2.108 hours 1compartment NA NA Rat Human +DTXSID7048794 Css NA 0.04364 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048794 Css NA 0.251 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048794 Css NA 0.02906 mg/L PBTK NA 50% Rat Human +DTXSID7048794 Css NA 0.1585 mg/L PBTK NA 95% Rat Human +DTXSID7048796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048796 Fup 0.0491 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048796 Vd NA 1.73 L/kg 1compartment NA NA Human Human +DTXSID7048796 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048796 TK.Half.Life NA 8.753 hours 1compartment NA NA Human Human +DTXSID7048796 Css NA 0.6694 mg/L 3compartmentss NA 50% Human Human +DTXSID7048796 Css NA 5.158 mg/L 3compartmentss NA 95% Human Human +DTXSID7048796 Css NA 0.4293 mg/L PBTK NA 50% Human Human +DTXSID7048796 Css NA 3.152 mg/L PBTK NA 95% Human Human +DTXSID7048796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048796 Fup 0.0491 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048796 Vd NA 1.293 L/kg 1compartment NA NA Rat Human +DTXSID7048796 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048796 TK.Half.Life NA 3.121 hours 1compartment NA NA Rat Human +DTXSID7048796 Css NA 0.0875 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048796 Css NA 0.5161 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048796 Css NA 0.055 mg/L PBTK NA 50% Rat Human +DTXSID7048796 Css NA 0.3123 mg/L PBTK NA 95% Rat Human DTXSID7048798 Clint NA 242.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7048798 Fup NA 0.1035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048798 Vd NA 76.04 L/kg 1compartment NA NA Human Human -DTXSID7048798 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7048798 TK.Half.Life NA 22.25 hours 1compartment NA NA Human Human -DTXSID7048798 Css NA 0.00231 mg/L 3compartmentss NA 50% Human Human -DTXSID7048798 Css NA 0.0197 mg/L 3compartmentss NA 95% Human Human -DTXSID7048798 Css NA 0.02028 mg/L PBTK NA 50% Human Human -DTXSID7048798 Css NA 0.1231 mg/L PBTK NA 95% Human Human +DTXSID7048798 Vd NA 3.479 L/kg 1compartment NA NA Human Human +DTXSID7048798 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048798 TK.Half.Life NA 3.06 hours 1compartment NA NA Human Human +DTXSID7048798 Css NA 0.01334 mg/L 3compartmentss NA 50% Human Human +DTXSID7048798 Css NA 0.1185 mg/L 3compartmentss NA 95% Human Human +DTXSID7048798 Css NA 0.01044 mg/L PBTK NA 50% Human Human +DTXSID7048798 Css NA 0.08742 mg/L PBTK NA 95% Human Human DTXSID7048798 Clint NA 242.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7048798 Fup NA 0.1035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048798 Vd NA 65.15 L/kg 1compartment NA NA Rat Human -DTXSID7048798 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7048798 TK.Half.Life NA 4.354 hours 1compartment NA NA Rat Human -DTXSID7048798 Css NA 0.001158 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048798 Css NA 0.008021 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048798 Css NA 0.01098 mg/L PBTK NA 50% Rat Human -DTXSID7048798 Css NA 0.05921 mg/L PBTK NA 95% Rat Human -DTXSID7048821 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048821 Fup NA 0.3106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048821 Vd NA 0.4097 L/kg 1compartment NA NA Human Human +DTXSID7048798 Vd NA 2.818 L/kg 1compartment NA NA Rat Human +DTXSID7048798 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048798 TK.Half.Life NA 0.9865 hours 1compartment NA NA Rat Human +DTXSID7048798 Css NA 0.0006626 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048798 Css NA 0.006009 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048798 Css NA 0.0005243 mg/L PBTK NA 50% Rat Human +DTXSID7048798 Css NA 0.00431 mg/L PBTK NA 95% Rat Human +DTXSID7048821 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048821 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048821 Vd NA 0.4111 L/kg 1compartment NA NA Human Human DTXSID7048821 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048821 TK.Half.Life NA 8.556 hours 1compartment NA NA Human Human -DTXSID7048821 Css NA 2.541 mg/L 3compartmentss NA 50% Human Human -DTXSID7048821 Css NA 10.02 mg/L 3compartmentss NA 95% Human Human -DTXSID7048821 Css NA 1.719 mg/L PBTK NA 50% Human Human -DTXSID7048821 Css NA 6.168 mg/L PBTK NA 95% Human Human -DTXSID7048821 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048821 Fup NA 0.3106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048821 Vd NA 0.4051 L/kg 1compartment NA NA Rat Human +DTXSID7048821 TK.Half.Life NA 8.469 hours 1compartment NA NA Human Human +DTXSID7048821 Css NA 1.312 mg/L 3compartmentss NA 50% Human Human +DTXSID7048821 Css NA 5.739 mg/L 3compartmentss NA 95% Human Human +DTXSID7048821 Css NA 0.8964 mg/L PBTK NA 50% Human Human +DTXSID7048821 Css NA 3.525 mg/L PBTK NA 95% Human Human +DTXSID7048821 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048821 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048821 Vd NA 0.4069 L/kg 1compartment NA NA Rat Human DTXSID7048821 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048821 TK.Half.Life NA 2.877 hours 1compartment NA NA Rat Human -DTXSID7048821 Css NA 0.7032 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048821 Css NA 2.304 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048821 Css NA 0.4514 mg/L PBTK NA 50% Rat Human -DTXSID7048821 Css NA 1.324 mg/L PBTK NA 95% Rat Human -DTXSID7048823 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048823 Fup NA 0.4443 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048823 Vd NA 10.44 L/kg 1compartment NA NA Human Human -DTXSID7048823 Days.Css NA 11150 Days PBTK NA NA Human Human -DTXSID7048823 TK.Half.Life NA 299900 hours 1compartment NA NA Human Human -DTXSID7048823 Css NA 1829 mg/L 3compartmentss NA 50% Human Human -DTXSID7048823 Css NA 5698 mg/L 3compartmentss NA 95% Human Human -DTXSID7048823 Css NA 2266 mg/L PBTK NA 50% Human Human -DTXSID7048823 Css NA 5619 mg/L PBTK NA 95% Human Human -DTXSID7048823 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048823 Fup NA 0.4443 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048823 Vd NA 8.239 L/kg 1compartment NA NA Rat Human -DTXSID7048823 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID7048823 TK.Half.Life NA 19260 hours 1compartment NA NA Rat Human -DTXSID7048823 Css NA 466.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048823 Css NA 1280 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048823 Css NA 586.4 mg/L PBTK NA 50% Rat Human -DTXSID7048823 Css NA 1157 mg/L PBTK NA 95% Rat Human -DTXSID7048825 Clint NA 246.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048825 Fup NA 0.1112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048825 Vd NA 1.234 L/kg 1compartment NA NA Human Human +DTXSID7048821 TK.Half.Life NA 2.85 hours 1compartment NA NA Rat Human +DTXSID7048821 Css NA 0.007152 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048821 Css NA 0.03122 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048821 Css NA 0.004637 mg/L PBTK NA 50% Rat Human +DTXSID7048821 Css NA 0.01831 mg/L PBTK NA 95% Rat Human +DTXSID7048823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048823 Fup 0.0584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048823 Vd NA 3.13 L/kg 1compartment NA NA Human Human +DTXSID7048823 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID7048823 TK.Half.Life NA 65.33 hours 1compartment NA NA Human Human +DTXSID7048823 Css NA 2.437 mg/L 3compartmentss NA 50% Human Human +DTXSID7048823 Css NA 15.76 mg/L 3compartmentss NA 95% Human Human +DTXSID7048823 Css NA 1.701 mg/L PBTK NA 50% Human Human +DTXSID7048823 Css NA 10.71 mg/L PBTK NA 95% Human Human +DTXSID7048823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048823 Fup 0.0584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048823 Vd NA 2.356 L/kg 1compartment NA NA Rat Human +DTXSID7048823 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID7048823 TK.Half.Life NA 9.19 hours 1compartment NA NA Rat Human +DTXSID7048823 Css NA 0.3151 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048823 Css NA 1.88 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048823 Css NA 0.2185 mg/L PBTK NA 50% Rat Human +DTXSID7048823 Css NA 1.257 mg/L PBTK NA 95% Rat Human +DTXSID7048825 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048825 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048825 Vd NA 1.435 L/kg 1compartment NA NA Human Human DTXSID7048825 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048825 TK.Half.Life NA 1.222 hours 1compartment NA NA Human Human -DTXSID7048825 Css NA 0.02423 mg/L 3compartmentss NA 50% Human Human -DTXSID7048825 Css NA 0.205 mg/L 3compartmentss NA 95% Human Human -DTXSID7048825 Css NA 0.01607 mg/L PBTK NA 50% Human Human -DTXSID7048825 Css NA 0.1266 mg/L PBTK NA 95% Human Human -DTXSID7048825 Clint NA 246.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048825 Fup NA 0.1112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048825 Vd NA 0.9618 L/kg 1compartment NA NA Rat Human +DTXSID7048825 TK.Half.Life NA 2.196 hours 1compartment NA NA Human Human +DTXSID7048825 Css NA 0.09229 mg/L 3compartmentss NA 50% Human Human +DTXSID7048825 Css NA 0.6734 mg/L 3compartmentss NA 95% Human Human +DTXSID7048825 Css NA 0.06799 mg/L PBTK NA 50% Human Human +DTXSID7048825 Css NA 0.4553 mg/L PBTK NA 95% Human Human +DTXSID7048825 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048825 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048825 Vd NA 1.155 L/kg 1compartment NA NA Rat Human DTXSID7048825 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048825 TK.Half.Life NA 0.4384 hours 1compartment NA NA Rat Human -DTXSID7048825 Css NA 0.01386 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048825 Css NA 0.09409 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048825 Css NA 0.008658 mg/L PBTK NA 50% Rat Human -DTXSID7048825 Css NA 0.05599 mg/L PBTK NA 95% Rat Human -DTXSID7048827 Clint NA 1.325 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048827 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048827 Vd NA 0.7565 L/kg 1compartment NA NA Human Human -DTXSID7048827 Days.Css NA 47 Days PBTK NA NA Human Human -DTXSID7048827 TK.Half.Life NA 203.7 hours 1compartment NA NA Human Human -DTXSID7048827 Css NA 47.46 mg/L 3compartmentss NA 50% Human Human -DTXSID7048827 Css NA 335.6 mg/L 3compartmentss NA 95% Human Human -DTXSID7048827 Css NA 28.24 mg/L PBTK NA 50% Human Human -DTXSID7048827 Css NA 196.3 mg/L PBTK NA 95% Human Human -DTXSID7048827 Clint NA 1.325 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048827 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048827 Vd NA 0.5597 L/kg 1compartment NA NA Rat Human -DTXSID7048827 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID7048827 TK.Half.Life NA 78.19 hours 1compartment NA NA Rat Human -DTXSID7048827 Css NA 22.03 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048827 Css NA 128.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048827 Css NA 12.23 mg/L PBTK NA 50% Rat Human -DTXSID7048827 Css NA 70.02 mg/L PBTK NA 95% Rat Human -DTXSID7048829 Clint NA 19.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048829 Fup NA 0.2807 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048829 Vd NA 1.709 L/kg 1compartment NA NA Human Human +DTXSID7048825 TK.Half.Life NA 0.8812 hours 1compartment NA NA Rat Human +DTXSID7048825 Css NA 0.01178 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048825 Css NA 0.06319 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048825 Css NA 0.008648 mg/L PBTK NA 50% Rat Human +DTXSID7048825 Css NA 0.04267 mg/L PBTK NA 95% Rat Human +DTXSID7048827 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048827 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048827 Vd NA 1.262 L/kg 1compartment NA NA Human Human +DTXSID7048827 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048827 TK.Half.Life NA 8.492 hours 1compartment NA NA Human Human +DTXSID7048827 Css NA 1.022 mg/L 3compartmentss NA 50% Human Human +DTXSID7048827 Css NA 9.238 mg/L 3compartmentss NA 95% Human Human +DTXSID7048827 Css NA 0.6376 mg/L PBTK NA 50% Human Human +DTXSID7048827 Css NA 5.551 mg/L PBTK NA 95% Human Human +DTXSID7048827 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048827 Fup 0.0293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048827 Vd NA 0.9423 L/kg 1compartment NA NA Rat Human +DTXSID7048827 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048827 TK.Half.Life NA 3.492 hours 1compartment NA NA Rat Human +DTXSID7048827 Css NA 0.1318 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048827 Css NA 0.9591 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048827 Css NA 0.07944 mg/L PBTK NA 50% Rat Human +DTXSID7048827 Css NA 0.5576 mg/L PBTK NA 95% Rat Human +DTXSID7048829 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048829 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048829 Vd NA 1.757 L/kg 1compartment NA NA Human Human DTXSID7048829 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048829 TK.Half.Life NA 2.674 hours 1compartment NA NA Human Human -DTXSID7048829 Css NA 0.1024 mg/L 3compartmentss NA 50% Human Human -DTXSID7048829 Css NA 0.7063 mg/L 3compartmentss NA 95% Human Human -DTXSID7048829 Css NA 0.07675 mg/L PBTK NA 50% Human Human -DTXSID7048829 Css NA 0.494 mg/L PBTK NA 95% Human Human -DTXSID7048829 Clint NA 19.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048829 Fup NA 0.2807 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048829 Vd NA 1.358 L/kg 1compartment NA NA Rat Human +DTXSID7048829 TK.Half.Life NA 5.497 hours 1compartment NA NA Human Human +DTXSID7048829 Css NA 0.2832 mg/L 3compartmentss NA 50% Human Human +DTXSID7048829 Css NA 1.679 mg/L 3compartmentss NA 95% Human Human +DTXSID7048829 Css NA 0.2149 mg/L PBTK NA 50% Human Human +DTXSID7048829 Css NA 1.169 mg/L PBTK NA 95% Human Human +DTXSID7048829 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048829 Fup 0.299 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048829 Vd NA 1.397 L/kg 1compartment NA NA Rat Human DTXSID7048829 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048829 TK.Half.Life NA 1.01 hours 1compartment NA NA Rat Human -DTXSID7048829 Css NA 0.05533 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048829 Css NA 0.2826 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048829 Css NA 0.04014 mg/L PBTK NA 50% Rat Human -DTXSID7048829 Css NA 0.1909 mg/L PBTK NA 95% Rat Human -DTXSID7048871 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048871 Fup NA 0.2169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048871 Vd NA 3.709 L/kg 1compartment NA NA Human Human +DTXSID7048829 TK.Half.Life NA 2.048 hours 1compartment NA NA Rat Human +DTXSID7048829 Css NA 0.03314 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048829 Css NA 0.1402 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048829 Css NA 0.02525 mg/L PBTK NA 50% Rat Human +DTXSID7048829 Css NA 0.09542 mg/L PBTK NA 95% Rat Human +DTXSID7048871 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048871 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048871 Vd NA 2.366 L/kg 1compartment NA NA Human Human DTXSID7048871 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048871 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human -DTXSID7048871 Css NA 0.08586 mg/L 3compartmentss NA 50% Human Human -DTXSID7048871 Css NA 0.6371 mg/L 3compartmentss NA 95% Human Human -DTXSID7048871 Css NA 0.1026 mg/L PBTK NA 50% Human Human -DTXSID7048871 Css NA 0.6103 mg/L PBTK NA 95% Human Human -DTXSID7048871 Clint NA 11.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048871 Fup NA 0.2169 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048871 Vd NA 3.741 L/kg 1compartment NA NA Rat Human +DTXSID7048871 TK.Half.Life NA 5.914 hours 1compartment NA NA Human Human +DTXSID7048871 Css NA 0.1747 mg/L 3compartmentss NA 50% Human Human +DTXSID7048871 Css NA 1.231 mg/L 3compartmentss NA 95% Human Human +DTXSID7048871 Css NA 0.1703 mg/L PBTK NA 50% Human Human +DTXSID7048871 Css NA 0.9682 mg/L PBTK NA 95% Human Human +DTXSID7048871 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048871 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048871 Vd NA 2.38 L/kg 1compartment NA NA Rat Human DTXSID7048871 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048871 TK.Half.Life NA 3.42 hours 1compartment NA NA Rat Human -DTXSID7048871 Css NA 0.04369 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048871 Css NA 0.2719 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048871 Css NA 0.0522 mg/L PBTK NA 50% Rat Human -DTXSID7048871 Css NA 0.2446 mg/L PBTK NA 95% Rat Human -DTXSID7048873 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048873 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048873 Vd NA 1.183 L/kg 1compartment NA NA Human Human -DTXSID7048873 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7048873 TK.Half.Life NA 32.25 hours 1compartment NA NA Human Human -DTXSID7048873 Css NA 3.038 mg/L 3compartmentss NA 50% Human Human -DTXSID7048873 Css NA 11.41 mg/L 3compartmentss NA 95% Human Human -DTXSID7048873 Css NA 2.234 mg/L PBTK NA 50% Human Human -DTXSID7048873 Css NA 7.381 mg/L PBTK NA 95% Human Human -DTXSID7048873 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048873 Fup NA 0.2749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048873 Vd NA 0.9744 L/kg 1compartment NA NA Rat Human +DTXSID7048871 TK.Half.Life NA 3.527 hours 1compartment NA NA Rat Human +DTXSID7048871 Css NA 0.0203 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048871 Css NA 0.1114 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048871 Css NA 0.02015 mg/L PBTK NA 50% Rat Human +DTXSID7048871 Css NA 0.08427 mg/L PBTK NA 95% Rat Human +DTXSID7048873 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048873 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048873 Vd NA 1.59 L/kg 1compartment NA NA Human Human +DTXSID7048873 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7048873 TK.Half.Life NA 27.01 hours 1compartment NA NA Human Human +DTXSID7048873 Css NA 1.668 mg/L 3compartmentss NA 50% Human Human +DTXSID7048873 Css NA 7.853 mg/L 3compartmentss NA 95% Human Human +DTXSID7048873 Css NA 1.386 mg/L PBTK NA 50% Human Human +DTXSID7048873 Css NA 5.242 mg/L PBTK NA 95% Human Human +DTXSID7048873 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048873 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048873 Vd NA 1.319 L/kg 1compartment NA NA Rat Human DTXSID7048873 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048873 TK.Half.Life NA 8.11 hours 1compartment NA NA Rat Human -DTXSID7048873 Css NA 0.8317 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048873 Css NA 2.632 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048873 Css NA 0.5867 mg/L PBTK NA 50% Rat Human -DTXSID7048873 Css NA 1.582 mg/L PBTK NA 95% Rat Human -DTXSID7048875 Clint NA 17.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048875 Fup NA 0.0441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048875 Vd NA 1.056 L/kg 1compartment NA NA Human Human +DTXSID7048873 TK.Half.Life NA 6.359 hours 1compartment NA NA Rat Human +DTXSID7048873 Css NA 0.1044 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048873 Css NA 0.4266 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048873 Css NA 0.08666 mg/L PBTK NA 50% Rat Human +DTXSID7048873 Css NA 0.2749 mg/L PBTK NA 95% Rat Human +DTXSID7048875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048875 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048875 Vd NA 1.612 L/kg 1compartment NA NA Human Human DTXSID7048875 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048875 TK.Half.Life NA 5.96 hours 1compartment NA NA Human Human -DTXSID7048875 Css NA 0.8329 mg/L 3compartmentss NA 50% Human Human -DTXSID7048875 Css NA 7.066 mg/L 3compartmentss NA 95% Human Human -DTXSID7048875 Css NA 0.5195 mg/L PBTK NA 50% Human Human -DTXSID7048875 Css NA 4.248 mg/L PBTK NA 95% Human Human -DTXSID7048875 Clint NA 17.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048875 Fup NA 0.0441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048875 Vd NA 0.8005 L/kg 1compartment NA NA Rat Human +DTXSID7048875 TK.Half.Life NA 4.522 hours 1compartment NA NA Human Human +DTXSID7048875 Css NA 0.3001 mg/L 3compartmentss NA 50% Human Human +DTXSID7048875 Css NA 2.207 mg/L 3compartmentss NA 95% Human Human +DTXSID7048875 Css NA 0.1998 mg/L PBTK NA 50% Human Human +DTXSID7048875 Css NA 1.391 mg/L PBTK NA 95% Human Human +DTXSID7048875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048875 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048875 Vd NA 1.232 L/kg 1compartment NA NA Rat Human DTXSID7048875 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048875 TK.Half.Life NA 2.588 hours 1compartment NA NA Rat Human -DTXSID7048875 Css NA 0.4734 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048875 Css NA 3.048 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048875 Css NA 0.2762 mg/L PBTK NA 50% Rat Human -DTXSID7048875 Css NA 1.698 mg/L PBTK NA 95% Rat Human -DTXSID7048877 Clint NA 12.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048877 Fup NA 0.1235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048877 Vd NA 3.403 L/kg 1compartment NA NA Human Human +DTXSID7048875 TK.Half.Life NA 1.701 hours 1compartment NA NA Rat Human +DTXSID7048875 Css NA 0.03806 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048875 Css NA 0.2286 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048875 Css NA 0.02494 mg/L PBTK NA 50% Rat Human +DTXSID7048875 Css NA 0.1423 mg/L PBTK NA 95% Rat Human +DTXSID7048877 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048877 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048877 Vd NA 3.88 L/kg 1compartment NA NA Human Human DTXSID7048877 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048877 TK.Half.Life NA 10.76 hours 1compartment NA NA Human Human -DTXSID7048877 Css NA 0.2933 mg/L 3compartmentss NA 50% Human Human -DTXSID7048877 Css NA 2.096 mg/L 3compartmentss NA 95% Human Human -DTXSID7048877 Css NA 0.2469 mg/L PBTK NA 50% Human Human -DTXSID7048877 Css NA 1.611 mg/L PBTK NA 95% Human Human -DTXSID7048877 Clint NA 12.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048877 Fup NA 0.1235 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048877 Vd NA 2.957 L/kg 1compartment NA NA Rat Human +DTXSID7048877 TK.Half.Life NA 6.957 hours 1compartment NA NA Human Human +DTXSID7048877 Css NA 0.1114 mg/L 3compartmentss NA 50% Human Human +DTXSID7048877 Css NA 0.7392 mg/L 3compartmentss NA 95% Human Human +DTXSID7048877 Css NA 0.1058 mg/L PBTK NA 50% Human Human +DTXSID7048877 Css NA 0.6256 mg/L PBTK NA 95% Human Human +DTXSID7048877 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048877 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048877 Vd NA 3.403 L/kg 1compartment NA NA Rat Human DTXSID7048877 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048877 TK.Half.Life NA 3.66 hours 1compartment NA NA Rat Human -DTXSID7048877 Css NA 0.1592 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048877 Css NA 0.89 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048877 Css NA 0.131 mg/L PBTK NA 50% Rat Human -DTXSID7048877 Css NA 0.6549 mg/L PBTK NA 95% Rat Human -DTXSID7048879 Clint NA 1069 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048879 Fup NA 0.762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048879 Vd NA 2.551 L/kg 1compartment NA NA Human Human -DTXSID7048879 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048879 TK.Half.Life NA 1.111 hours 1compartment NA NA Human Human -DTXSID7048879 Css NA 0.0004696 mg/L 3compartmentss NA 50% Human Human -DTXSID7048879 Css NA 0.005636 mg/L 3compartmentss NA 95% Human Human -DTXSID7048879 Css NA 0.0005167 mg/L PBTK NA 50% Human Human -DTXSID7048879 Css NA 0.004738 mg/L PBTK NA 95% Human Human -DTXSID7048879 Clint NA 1069 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048879 Fup NA 0.762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048879 Vd NA 2.565 L/kg 1compartment NA NA Rat Human +DTXSID7048877 TK.Half.Life NA 2.211 hours 1compartment NA NA Rat Human +DTXSID7048877 Css NA 0.01361 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048877 Css NA 0.07781 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048877 Css NA 0.01313 mg/L PBTK NA 50% Rat Human +DTXSID7048877 Css NA 0.06644 mg/L PBTK NA 95% Rat Human +DTXSID7048879 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048879 Fup 0.653 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048879 Vd NA 2.749 L/kg 1compartment NA NA Human Human +DTXSID7048879 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7048879 TK.Half.Life NA 27.25 hours 1compartment NA NA Human Human +DTXSID7048879 Css NA 0.7667 mg/L 3compartmentss NA 50% Human Human +DTXSID7048879 Css NA 6.38 mg/L 3compartmentss NA 95% Human Human +DTXSID7048879 Css NA 0.8986 mg/L PBTK NA 50% Human Human +DTXSID7048879 Css NA 4.578 mg/L PBTK NA 95% Human Human +DTXSID7048879 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048879 Fup 0.653 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048879 Vd NA 2.764 L/kg 1compartment NA NA Rat Human DTXSID7048879 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048879 TK.Half.Life NA 0.4857 hours 1compartment NA NA Rat Human -DTXSID7048879 Css NA 0.0002362 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048879 Css NA 0.003106 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048879 Css NA 0.0002649 mg/L PBTK NA 50% Rat Human -DTXSID7048879 Css NA 0.002437 mg/L PBTK NA 95% Rat Human -DTXSID7048900 Clint NA 31.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048900 Fup NA 0.1571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048900 Vd NA 2.792 L/kg 1compartment NA NA Human Human +DTXSID7048879 TK.Half.Life NA 9.332 hours 1compartment NA NA Rat Human +DTXSID7048879 Css NA 0.04502 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048879 Css NA 0.364 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048879 Css NA 0.05394 mg/L PBTK NA 50% Rat Human +DTXSID7048879 Css NA 0.2531 mg/L PBTK NA 95% Rat Human +DTXSID7048900 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048900 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048900 Vd NA 2.54 L/kg 1compartment NA NA Human Human DTXSID7048900 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048900 TK.Half.Life NA 2.252 hours 1compartment NA NA Human Human -DTXSID7048900 Css NA 0.03032 mg/L 3compartmentss NA 50% Human Human -DTXSID7048900 Css NA 0.2993 mg/L 3compartmentss NA 95% Human Human -DTXSID7048900 Css NA 0.03267 mg/L PBTK NA 50% Human Human -DTXSID7048900 Css NA 0.2589 mg/L PBTK NA 95% Human Human -DTXSID7048900 Clint NA 31.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048900 Fup NA 0.1571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048900 Vd NA 2.752 L/kg 1compartment NA NA Rat Human +DTXSID7048900 TK.Half.Life NA 2.484 hours 1compartment NA NA Human Human +DTXSID7048900 Css NA 0.03814 mg/L 3compartmentss NA 50% Human Human +DTXSID7048900 Css NA 0.3369 mg/L 3compartmentss NA 95% Human Human +DTXSID7048900 Css NA 0.04193 mg/L PBTK NA 50% Human Human +DTXSID7048900 Css NA 0.2966 mg/L PBTK NA 95% Human Human +DTXSID7048900 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048900 Fup 0.254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048900 Vd NA 2.507 L/kg 1compartment NA NA Rat Human DTXSID7048900 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048900 TK.Half.Life NA 1.191 hours 1compartment NA NA Rat Human -DTXSID7048900 Css NA 0.01648 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048900 Css NA 0.1308 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048900 Css NA 0.0176 mg/L PBTK NA 50% Rat Human -DTXSID7048900 Css NA 0.1048 mg/L PBTK NA 95% Rat Human -DTXSID7048902 Clint NA 7.063 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048902 Fup NA 0.8055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048902 Vd NA 3.146 L/kg 1compartment NA NA Human Human +DTXSID7048900 TK.Half.Life NA 1.367 hours 1compartment NA NA Rat Human +DTXSID7048900 Css NA 0.004777 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048900 Css NA 0.03158 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048900 Css NA 0.005413 mg/L PBTK NA 50% Rat Human +DTXSID7048900 Css NA 0.02927 mg/L PBTK NA 95% Rat Human +DTXSID7048902 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048902 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048902 Vd NA 1.027 L/kg 1compartment NA NA Human Human DTXSID7048902 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048902 TK.Half.Life NA 2.979 hours 1compartment NA NA Human Human -DTXSID7048902 Css NA 0.05654 mg/L 3compartmentss NA 50% Human Human -DTXSID7048902 Css NA 0.5565 mg/L 3compartmentss NA 95% Human Human -DTXSID7048902 Css NA 0.06813 mg/L PBTK NA 50% Human Human -DTXSID7048902 Css NA 0.4806 mg/L PBTK NA 95% Human Human -DTXSID7048902 Clint NA 7.063 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048902 Fup NA 0.8055 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048902 Vd NA 3.168 L/kg 1compartment NA NA Rat Human +DTXSID7048902 TK.Half.Life NA 1.518 hours 1compartment NA NA Human Human +DTXSID7048902 Css NA 0.1059 mg/L 3compartmentss NA 50% Human Human +DTXSID7048902 Css NA 0.9581 mg/L 3compartmentss NA 95% Human Human +DTXSID7048902 Css NA 0.08905 mg/L PBTK NA 50% Human Human +DTXSID7048902 Css NA 0.6545 mg/L PBTK NA 95% Human Human +DTXSID7048902 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048902 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048902 Vd NA 1.048 L/kg 1compartment NA NA Rat Human DTXSID7048902 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048902 TK.Half.Life NA 1.659 hours 1compartment NA NA Rat Human -DTXSID7048902 Css NA 0.02608 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048902 Css NA 0.2393 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048902 Css NA 0.03224 mg/L PBTK NA 50% Rat Human -DTXSID7048902 Css NA 0.1818 mg/L PBTK NA 95% Rat Human -DTXSID7048904 Clint NA 18.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048904 Fup NA 0.4317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048904 Vd NA 2.102 L/kg 1compartment NA NA Human Human +DTXSID7048902 TK.Half.Life NA 0.8471 hours 1compartment NA NA Rat Human +DTXSID7048902 Css NA 0.01198 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048902 Css NA 0.09816 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048902 Css NA 0.01022 mg/L PBTK NA 50% Rat Human +DTXSID7048902 Css NA 0.06302 mg/L PBTK NA 95% Rat Human +DTXSID7048904 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048904 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048904 Vd NA 2.395 L/kg 1compartment NA NA Human Human DTXSID7048904 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048904 TK.Half.Life NA 2.078 hours 1compartment NA NA Human Human -DTXSID7048904 Css NA 0.04387 mg/L 3compartmentss NA 50% Human Human -DTXSID7048904 Css NA 0.3727 mg/L 3compartmentss NA 95% Human Human -DTXSID7048904 Css NA 0.04264 mg/L PBTK NA 50% Human Human -DTXSID7048904 Css NA 0.2967 mg/L PBTK NA 95% Human Human -DTXSID7048904 Clint NA 18.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048904 Fup NA 0.4317 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048904 Vd NA 2.118 L/kg 1compartment NA NA Rat Human +DTXSID7048904 TK.Half.Life NA 3.276 hours 1compartment NA NA Human Human +DTXSID7048904 Css NA 0.08538 mg/L 3compartmentss NA 50% Human Human +DTXSID7048904 Css NA 0.9288 mg/L 3compartmentss NA 95% Human Human +DTXSID7048904 Css NA 0.0894 mg/L PBTK NA 50% Human Human +DTXSID7048904 Css NA 0.6938 mg/L PBTK NA 95% Human Human +DTXSID7048904 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048904 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048904 Vd NA 2.425 L/kg 1compartment NA NA Rat Human DTXSID7048904 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048904 TK.Half.Life NA 1.121 hours 1compartment NA NA Rat Human -DTXSID7048904 Css NA 0.02268 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048904 Css NA 0.1589 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048904 Css NA 0.02159 mg/L PBTK NA 50% Rat Human -DTXSID7048904 Css NA 0.1172 mg/L PBTK NA 95% Rat Human -DTXSID7048906 Clint NA 2.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048906 Fup NA 0.5203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048906 Vd NA 2.122 L/kg 1compartment NA NA Human Human -DTXSID7048906 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048906 TK.Half.Life NA 6.161 hours 1compartment NA NA Human Human -DTXSID7048906 Css NA 0.2364 mg/L 3compartmentss NA 50% Human Human -DTXSID7048906 Css NA 1.732 mg/L 3compartmentss NA 95% Human Human -DTXSID7048906 Css NA 0.2345 mg/L PBTK NA 50% Human Human -DTXSID7048906 Css NA 1.28 mg/L PBTK NA 95% Human Human -DTXSID7048906 Clint NA 2.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048906 Fup NA 0.5203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048906 Vd NA 2.147 L/kg 1compartment NA NA Rat Human +DTXSID7048904 TK.Half.Life NA 1.848 hours 1compartment NA NA Rat Human +DTXSID7048904 Css NA 0.009408 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048904 Css NA 0.08997 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048904 Css NA 0.01015 mg/L PBTK NA 50% Rat Human +DTXSID7048904 Css NA 0.06269 mg/L PBTK NA 95% Rat Human +DTXSID7048906 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048906 Fup 0.477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048906 Vd NA 1.887 L/kg 1compartment NA NA Human Human +DTXSID7048906 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID7048906 TK.Half.Life NA 26.27 hours 1compartment NA NA Human Human +DTXSID7048906 Css NA 1.202 mg/L 3compartmentss NA 50% Human Human +DTXSID7048906 Css NA 6.488 mg/L 3compartmentss NA 95% Human Human +DTXSID7048906 Css NA 1.137 mg/L PBTK NA 50% Human Human +DTXSID7048906 Css NA 4.568 mg/L PBTK NA 95% Human Human +DTXSID7048906 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048906 Fup 0.477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048906 Vd NA 1.876 L/kg 1compartment NA NA Rat Human DTXSID7048906 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048906 TK.Half.Life NA 3.385 hours 1compartment NA NA Rat Human -DTXSID7048906 Css NA 0.1021 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048906 Css NA 0.6625 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048906 Css NA 0.1006 mg/L PBTK NA 50% Rat Human -DTXSID7048906 Css NA 0.4456 mg/L PBTK NA 95% Rat Human -DTXSID7048908 Clint NA 12.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048908 Fup NA 0.5285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048908 Vd NA 2.924 L/kg 1compartment NA NA Human Human +DTXSID7048906 TK.Half.Life NA 8.728 hours 1compartment NA NA Rat Human +DTXSID7048906 Css NA 0.07472 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048906 Css NA 0.3695 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048906 Css NA 0.07114 mg/L PBTK NA 50% Rat Human +DTXSID7048906 Css NA 0.2486 mg/L PBTK NA 95% Rat Human +DTXSID7048908 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048908 Fup 0.595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048908 Vd NA 2.874 L/kg 1compartment NA NA Human Human DTXSID7048908 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048908 TK.Half.Life NA 2.777 hours 1compartment NA NA Human Human -DTXSID7048908 Css NA 0.0451 mg/L 3compartmentss NA 50% Human Human -DTXSID7048908 Css NA 0.4435 mg/L 3compartmentss NA 95% Human Human -DTXSID7048908 Css NA 0.05044 mg/L PBTK NA 50% Human Human -DTXSID7048908 Css NA 0.3659 mg/L PBTK NA 95% Human Human -DTXSID7048908 Clint NA 12.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048908 Fup NA 0.5285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048908 Vd NA 2.967 L/kg 1compartment NA NA Rat Human +DTXSID7048908 TK.Half.Life NA 3.779 hours 1compartment NA NA Human Human +DTXSID7048908 Css NA 0.07923 mg/L 3compartmentss NA 50% Human Human +DTXSID7048908 Css NA 0.8449 mg/L 3compartmentss NA 95% Human Human +DTXSID7048908 Css NA 0.08862 mg/L PBTK NA 50% Human Human +DTXSID7048908 Css NA 0.6651 mg/L PBTK NA 95% Human Human +DTXSID7048908 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048908 Fup 0.595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048908 Vd NA 2.918 L/kg 1compartment NA NA Rat Human DTXSID7048908 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048908 TK.Half.Life NA 1.551 hours 1compartment NA NA Rat Human -DTXSID7048908 Css NA 0.02262 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048908 Css NA 0.1921 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048908 Css NA 0.02537 mg/L PBTK NA 50% Rat Human -DTXSID7048908 Css NA 0.1433 mg/L PBTK NA 95% Rat Human -DTXSID7048950 Clint NA 9.503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048950 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048950 Vd NA 0.3594 L/kg 1compartment NA NA Human Human +DTXSID7048908 TK.Half.Life NA 2.163 hours 1compartment NA NA Rat Human +DTXSID7048908 Css NA 0.00861 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048908 Css NA 0.08701 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048908 Css NA 0.01012 mg/L PBTK NA 50% Rat Human +DTXSID7048908 Css NA 0.062 mg/L PBTK NA 95% Rat Human +DTXSID7048950 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048950 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048950 Vd NA 0.6542 L/kg 1compartment NA NA Human Human DTXSID7048950 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048950 TK.Half.Life NA 4.042 hours 1compartment NA NA Human Human -DTXSID7048950 Css NA 2.052 mg/L 3compartmentss NA 50% Human Human -DTXSID7048950 Css NA 14.64 mg/L 3compartmentss NA 95% Human Human -DTXSID7048950 Css NA 1.216 mg/L PBTK NA 50% Human Human -DTXSID7048950 Css NA 8.466 mg/L PBTK NA 95% Human Human -DTXSID7048950 Clint NA 9.503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048950 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048950 Vd NA 0.3078 L/kg 1compartment NA NA Rat Human +DTXSID7048950 TK.Half.Life NA 3.114 hours 1compartment NA NA Human Human +DTXSID7048950 Css NA 0.5986 mg/L 3compartmentss NA 50% Human Human +DTXSID7048950 Css NA 4.132 mg/L 3compartmentss NA 95% Human Human +DTXSID7048950 Css NA 0.3897 mg/L PBTK NA 50% Human Human +DTXSID7048950 Css NA 2.513 mg/L PBTK NA 95% Human Human +DTXSID7048950 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048950 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048950 Vd NA 0.5598 L/kg 1compartment NA NA Rat Human DTXSID7048950 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048950 TK.Half.Life NA 2.2 hours 1compartment NA NA Rat Human -DTXSID7048950 Css NA 1.124 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048950 Css NA 5.943 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048950 Css NA 0.6264 mg/L PBTK NA 50% Rat Human -DTXSID7048950 Css NA 3.245 mg/L PBTK NA 95% Rat Human +DTXSID7048950 TK.Half.Life NA 1.563 hours 1compartment NA NA Rat Human +DTXSID7048950 Css NA 0.07267 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048950 Css NA 0.3721 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048950 Css NA 0.0463 mg/L PBTK NA 50% Rat Human +DTXSID7048950 Css NA 0.2207 mg/L PBTK NA 95% Rat Human DTXSID7048952 Clint NA 61.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7048952 Fup NA 0.4912 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048952 Vd NA 3.023 L/kg 1compartment NA NA Human Human +DTXSID7048952 Vd NA 0.3581 L/kg 1compartment NA NA Human Human DTXSID7048952 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048952 TK.Half.Life NA 1.8 hours 1compartment NA NA Human Human -DTXSID7048952 Css NA 0.01104 mg/L 3compartmentss NA 50% Human Human -DTXSID7048952 Css NA 0.1154 mg/L 3compartmentss NA 95% Human Human -DTXSID7048952 Css NA 0.01184 mg/L PBTK NA 50% Human Human -DTXSID7048952 Css NA 0.09691 mg/L PBTK NA 95% Human Human +DTXSID7048952 TK.Half.Life NA 0.3152 hours 1compartment NA NA Human Human +DTXSID7048952 Css NA 0.009559 mg/L 3compartmentss NA 50% Human Human +DTXSID7048952 Css NA 0.1134 mg/L 3compartmentss NA 95% Human Human +DTXSID7048952 Css NA 0.006558 mg/L PBTK NA 50% Human Human +DTXSID7048952 Css NA 0.07307 mg/L PBTK NA 95% Human Human DTXSID7048952 Clint NA 61.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7048952 Fup NA 0.4912 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048952 Vd NA 3.112 L/kg 1compartment NA NA Rat Human +DTXSID7048952 Vd NA 0.3794 L/kg 1compartment NA NA Rat Human DTXSID7048952 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048952 TK.Half.Life NA 0.8936 hours 1compartment NA NA Rat Human -DTXSID7048952 Css NA 0.0056 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048952 Css NA 0.05216 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048952 Css NA 0.006095 mg/L PBTK NA 50% Rat Human -DTXSID7048952 Css NA 0.04222 mg/L PBTK NA 95% Rat Human -DTXSID7048954 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048954 Fup NA 0.3325 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048954 Vd NA 0.7346 L/kg 1compartment NA NA Human Human -DTXSID7048954 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7048954 TK.Half.Life NA 14.37 hours 1compartment NA NA Human Human -DTXSID7048954 Css NA 2.189 mg/L 3compartmentss NA 50% Human Human -DTXSID7048954 Css NA 8.997 mg/L 3compartmentss NA 95% Human Human -DTXSID7048954 Css NA 1.614 mg/L PBTK NA 50% Human Human -DTXSID7048954 Css NA 5.72 mg/L PBTK NA 95% Human Human -DTXSID7048954 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048954 Fup NA 0.3325 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048954 Vd NA 0.7259 L/kg 1compartment NA NA Rat Human -DTXSID7048954 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048954 TK.Half.Life NA 4.82 hours 1compartment NA NA Rat Human -DTXSID7048954 Css NA 0.5998 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048954 Css NA 2.128 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048954 Css NA 0.4225 mg/L PBTK NA 50% Rat Human -DTXSID7048954 Css NA 1.266 mg/L PBTK NA 95% Rat Human -DTXSID7048956 Clint NA 230.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048956 Fup NA 0.3006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048956 Vd NA 2.926 L/kg 1compartment NA NA Human Human -DTXSID7048956 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7048956 TK.Half.Life NA 3.035 hours 1compartment NA NA Human Human -DTXSID7048956 Css NA 0.03242 mg/L 3compartmentss NA 50% Human Human -DTXSID7048956 Css NA 0.2126 mg/L 3compartmentss NA 95% Human Human -DTXSID7048956 Css NA 0.02349 mg/L PBTK NA 50% Human Human -DTXSID7048956 Css NA 0.1473 mg/L PBTK NA 95% Human Human -DTXSID7048956 Clint NA 230.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048956 Fup NA 0.3006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048956 Vd NA 2.22 L/kg 1compartment NA NA Rat Human -DTXSID7048956 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7048956 TK.Half.Life NA 0.8799 hours 1compartment NA NA Rat Human -DTXSID7048956 Css NA 0.01795 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048956 Css NA 0.09836 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048956 Css NA 0.01258 mg/L PBTK NA 50% Rat Human -DTXSID7048956 Css NA 0.06522 mg/L PBTK NA 95% Rat Human -DTXSID7048958 Clint NA 8.792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048958 Fup NA 0.0291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7048958 Vd NA 1.72 L/kg 1compartment NA NA Human Human -DTXSID7048958 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7048958 TK.Half.Life NA 28.26 hours 1compartment NA NA Human Human -DTXSID7048958 Css NA 2.649 mg/L 3compartmentss NA 50% Human Human -DTXSID7048958 Css NA 20.34 mg/L 3compartmentss NA 95% Human Human -DTXSID7048958 Css NA 1.689 mg/L PBTK NA 50% Human Human -DTXSID7048958 Css NA 12.49 mg/L PBTK NA 95% Human Human -DTXSID7048958 Clint NA 8.792 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048958 Fup NA 0.0291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7048958 Vd NA 1.279 L/kg 1compartment NA NA Rat Human -DTXSID7048958 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7048958 TK.Half.Life NA 9.922 hours 1compartment NA NA Rat Human -DTXSID7048958 Css NA 1.452 mg/L 3compartmentss NA 50% Rat Human -DTXSID7048958 Css NA 8.415 mg/L 3compartmentss NA 95% Rat Human -DTXSID7048958 Css NA 0.869 mg/L PBTK NA 50% Rat Human -DTXSID7048958 Css NA 4.792 mg/L PBTK NA 95% Rat Human -DTXSID7049001 Clint NA 75.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049001 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049001 Vd NA 3.914 L/kg 1compartment NA NA Human Human +DTXSID7048952 TK.Half.Life NA 0.1538 hours 1compartment NA NA Rat Human +DTXSID7048952 Css NA 0.0003356 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048952 Css NA 0.004703 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048952 Css NA 0.0002238 mg/L PBTK NA 50% Rat Human +DTXSID7048952 Css NA 0.002866 mg/L PBTK NA 95% Rat Human +DTXSID7048956 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048956 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048956 Vd NA 2.963 L/kg 1compartment NA NA Human Human +DTXSID7048956 Days.Css NA 107 Days PBTK NA NA Human Human +DTXSID7048956 TK.Half.Life NA 458.4 hours 1compartment NA NA Human Human +DTXSID7048956 Css NA 14.43 mg/L 3compartmentss NA 50% Human Human +DTXSID7048956 Css NA 42.5 mg/L 3compartmentss NA 95% Human Human +DTXSID7048956 Css NA 10.64 mg/L PBTK NA 50% Human Human +DTXSID7048956 Css NA 28.66 mg/L PBTK NA 95% Human Human +DTXSID7048956 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048956 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048956 Vd NA 2.248 L/kg 1compartment NA NA Rat Human +DTXSID7048956 Days.Css NA 26 Days PBTK NA NA Rat Human +DTXSID7048956 TK.Half.Life NA 39.32 hours 1compartment NA NA Rat Human +DTXSID7048956 Css NA 0.3542 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048956 Css NA 1.47 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048956 Css NA 0.2536 mg/L PBTK NA 50% Rat Human +DTXSID7048956 Css NA 0.9829 mg/L PBTK NA 95% Rat Human +DTXSID7048958 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048958 Fup 0.0348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7048958 Vd NA 1.841 L/kg 1compartment NA NA Human Human +DTXSID7048958 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7048958 TK.Half.Life NA 12.31 hours 1compartment NA NA Human Human +DTXSID7048958 Css NA 0.8359 mg/L 3compartmentss NA 50% Human Human +DTXSID7048958 Css NA 6.089 mg/L 3compartmentss NA 95% Human Human +DTXSID7048958 Css NA 0.5357 mg/L PBTK NA 50% Human Human +DTXSID7048958 Css NA 3.796 mg/L PBTK NA 95% Human Human +DTXSID7048958 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048958 Fup 0.0348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7048958 Vd NA 1.371 L/kg 1compartment NA NA Rat Human +DTXSID7048958 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7048958 TK.Half.Life NA 4.216 hours 1compartment NA NA Rat Human +DTXSID7048958 Css NA 0.04184 mg/L 3compartmentss NA 50% Rat Human +DTXSID7048958 Css NA 0.3225 mg/L 3compartmentss NA 95% Rat Human +DTXSID7048958 Css NA 0.026 mg/L PBTK NA 50% Rat Human +DTXSID7048958 Css NA 0.1926 mg/L PBTK NA 95% Rat Human +DTXSID7049001 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049001 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049001 Vd NA 1.452 L/kg 1compartment NA NA Human Human DTXSID7049001 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049001 TK.Half.Life NA 2.068 hours 1compartment NA NA Human Human -DTXSID7049001 Css NA 0.008536 mg/L 3compartmentss NA 50% Human Human -DTXSID7049001 Css NA 0.08216 mg/L 3compartmentss NA 95% Human Human -DTXSID7049001 Css NA 0.01093 mg/L PBTK NA 50% Human Human -DTXSID7049001 Css NA 0.07928 mg/L PBTK NA 95% Human Human -DTXSID7049001 Clint NA 75.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049001 Fup NA 0.3766 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049001 Vd NA 3.983 L/kg 1compartment NA NA Rat Human +DTXSID7049001 TK.Half.Life NA 2.686 hours 1compartment NA NA Human Human +DTXSID7049001 Css NA 0.131 mg/L 3compartmentss NA 50% Human Human +DTXSID7049001 Css NA 1.018 mg/L 3compartmentss NA 95% Human Human +DTXSID7049001 Css NA 0.114 mg/L PBTK NA 50% Human Human +DTXSID7049001 Css NA 0.7207 mg/L PBTK NA 95% Human Human +DTXSID7049001 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049001 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049001 Vd NA 1.463 L/kg 1compartment NA NA Rat Human DTXSID7049001 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049001 TK.Half.Life NA 1.025 hours 1compartment NA NA Rat Human -DTXSID7049001 Css NA 0.004523 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049001 Css NA 0.03597 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049001 Css NA 0.00576 mg/L PBTK NA 50% Rat Human -DTXSID7049001 Css NA 0.03433 mg/L PBTK NA 95% Rat Human -DTXSID7049003 Clint NA 30.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049003 Fup NA 0.5004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049003 Vd NA 2.114 L/kg 1compartment NA NA Human Human +DTXSID7049001 TK.Half.Life NA 1.53 hours 1compartment NA NA Rat Human +DTXSID7049001 Css NA 0.01519 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049001 Css NA 0.08606 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049001 Css NA 0.0133 mg/L PBTK NA 50% Rat Human +DTXSID7049001 Css NA 0.0599 mg/L PBTK NA 95% Rat Human +DTXSID7049003 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049003 Fup 0.491 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049003 Vd NA 2.7 L/kg 1compartment NA NA Human Human DTXSID7049003 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049003 TK.Half.Life NA 1.573 hours 1compartment NA NA Human Human -DTXSID7049003 Css NA 0.02336 mg/L 3compartmentss NA 50% Human Human -DTXSID7049003 Css NA 0.2182 mg/L 3compartmentss NA 95% Human Human -DTXSID7049003 Css NA 0.02341 mg/L PBTK NA 50% Human Human -DTXSID7049003 Css NA 0.1736 mg/L PBTK NA 95% Human Human -DTXSID7049003 Clint NA 30.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049003 Fup NA 0.5004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049003 Vd NA 2.115 L/kg 1compartment NA NA Rat Human +DTXSID7049003 TK.Half.Life NA 4.049 hours 1compartment NA NA Human Human +DTXSID7049003 Css NA 0.0871 mg/L 3compartmentss NA 50% Human Human +DTXSID7049003 Css NA 0.7622 mg/L 3compartmentss NA 95% Human Human +DTXSID7049003 Css NA 0.09888 mg/L PBTK NA 50% Human Human +DTXSID7049003 Css NA 0.6271 mg/L PBTK NA 95% Human Human +DTXSID7049003 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049003 Fup 0.491 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049003 Vd NA 2.71 L/kg 1compartment NA NA Rat Human DTXSID7049003 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049003 TK.Half.Life NA 0.7998 hours 1compartment NA NA Rat Human -DTXSID7049003 Css NA 0.01198 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049003 Css NA 0.09575 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049003 Css NA 0.01198 mg/L PBTK NA 50% Rat Human -DTXSID7049003 Css NA 0.07375 mg/L PBTK NA 95% Rat Human -DTXSID7049005 Clint NA 3.394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049005 Fup NA 0.0471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049005 Vd NA 1.378 L/kg 1compartment NA NA Human Human -DTXSID7049005 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7049005 TK.Half.Life NA 32.22 hours 1compartment NA NA Human Human -DTXSID7049005 Css NA 3.75 mg/L 3compartmentss NA 50% Human Human -DTXSID7049005 Css NA 22.99 mg/L 3compartmentss NA 95% Human Human -DTXSID7049005 Css NA 2.393 mg/L PBTK NA 50% Human Human -DTXSID7049005 Css NA 14.08 mg/L PBTK NA 95% Human Human -DTXSID7049005 Clint NA 3.394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049005 Fup NA 0.0471 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049005 Vd NA 1.032 L/kg 1compartment NA NA Rat Human -DTXSID7049005 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7049005 TK.Half.Life NA 11.93 hours 1compartment NA NA Rat Human -DTXSID7049005 Css NA 1.907 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049005 Css NA 8.297 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049005 Css NA 1.143 mg/L PBTK NA 50% Rat Human -DTXSID7049005 Css NA 4.671 mg/L PBTK NA 95% Rat Human -DTXSID7049007 Clint NA 2.696 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049007 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049007 Vd NA 0.9658 L/kg 1compartment NA NA Human Human -DTXSID7049007 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7049007 TK.Half.Life NA 12.49 hours 1compartment NA NA Human Human -DTXSID7049007 Css NA 1.93 mg/L 3compartmentss NA 50% Human Human -DTXSID7049007 Css NA 11.67 mg/L 3compartmentss NA 95% Human Human -DTXSID7049007 Css NA 1.276 mg/L PBTK NA 50% Human Human -DTXSID7049007 Css NA 7.064 mg/L PBTK NA 95% Human Human -DTXSID7049007 Clint NA 2.696 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049007 Fup NA 0.0963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049007 Vd NA 0.8512 L/kg 1compartment NA NA Rat Human -DTXSID7049007 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049007 TK.Half.Life NA 6.118 hours 1compartment NA NA Rat Human -DTXSID7049007 Css NA 0.9365 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049007 Css NA 4.192 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049007 Css NA 0.5824 mg/L PBTK NA 50% Rat Human -DTXSID7049007 Css NA 2.379 mg/L PBTK NA 95% Rat Human +DTXSID7049003 TK.Half.Life NA 2.328 hours 1compartment NA NA Rat Human +DTXSID7049003 Css NA 0.00969 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049003 Css NA 0.07476 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049003 Css NA 0.01135 mg/L PBTK NA 50% Rat Human +DTXSID7049003 Css NA 0.05695 mg/L PBTK NA 95% Rat Human +DTXSID7049005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049005 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049005 Vd NA 1.934 L/kg 1compartment NA NA Human Human +DTXSID7049005 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7049005 TK.Half.Life NA 5.97 hours 1compartment NA NA Human Human +DTXSID7049005 Css NA 0.3299 mg/L 3compartmentss NA 50% Human Human +DTXSID7049005 Css NA 2.282 mg/L 3compartmentss NA 95% Human Human +DTXSID7049005 Css NA 0.2239 mg/L PBTK NA 50% Human Human +DTXSID7049005 Css NA 1.472 mg/L PBTK NA 95% Human Human +DTXSID7049005 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049005 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049005 Vd NA 1.462 L/kg 1compartment NA NA Rat Human +DTXSID7049005 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7049005 TK.Half.Life NA 2.006 hours 1compartment NA NA Rat Human +DTXSID7049005 Css NA 0.04205 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049005 Css NA 0.2459 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049005 Css NA 0.02826 mg/L PBTK NA 50% Rat Human +DTXSID7049005 Css NA 0.1557 mg/L PBTK NA 95% Rat Human +DTXSID7049007 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049007 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049007 Vd NA 2.645 L/kg 1compartment NA NA Human Human +DTXSID7049007 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID7049007 TK.Half.Life NA 156 hours 1compartment NA NA Human Human +DTXSID7049007 Css NA 6.155 mg/L 3compartmentss NA 50% Human Human +DTXSID7049007 Css NA 19.04 mg/L 3compartmentss NA 95% Human Human +DTXSID7049007 Css NA 4.699 mg/L PBTK NA 50% Human Human +DTXSID7049007 Css NA 13 mg/L PBTK NA 95% Human Human +DTXSID7049007 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049007 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049007 Vd NA 2.035 L/kg 1compartment NA NA Rat Human +DTXSID7049007 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID7049007 TK.Half.Life NA 19.16 hours 1compartment NA NA Rat Human +DTXSID7049007 Css NA 0.3867 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049007 Css NA 0.9627 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049007 Css NA 0.2944 mg/L PBTK NA 50% Rat Human +DTXSID7049007 Css NA 0.6297 mg/L PBTK NA 95% Rat Human DTXSID7049009 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7049009 Fup NA 0.2191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049009 Vd NA 2.7 L/kg 1compartment NA NA Human Human -DTXSID7049009 Days.Css NA 50 Days PBTK NA NA Human Human -DTXSID7049009 TK.Half.Life NA 237.4 hours 1compartment NA NA Human Human -DTXSID7049009 Css NA 9.513 mg/L 3compartmentss NA 50% Human Human -DTXSID7049009 Css NA 28.64 mg/L 3compartmentss NA 95% Human Human -DTXSID7049009 Css NA 7.207 mg/L PBTK NA 50% Human Human -DTXSID7049009 Css NA 19.27 mg/L PBTK NA 95% Human Human +DTXSID7049009 Vd NA 0.3679 L/kg 1compartment NA NA Human Human +DTXSID7049009 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7049009 TK.Half.Life NA 10.87 hours 1compartment NA NA Human Human +DTXSID7049009 Css NA 3.064 mg/L 3compartmentss NA 50% Human Human +DTXSID7049009 Css NA 11.36 mg/L 3compartmentss NA 95% Human Human +DTXSID7049009 Css NA 2.026 mg/L PBTK NA 50% Human Human +DTXSID7049009 Css NA 6.91 mg/L PBTK NA 95% Human Human DTXSID7049009 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7049009 Fup NA 0.2191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049009 Vd NA 2.116 L/kg 1compartment NA NA Rat Human -DTXSID7049009 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID7049009 TK.Half.Life NA 31.34 hours 1compartment NA NA Rat Human -DTXSID7049009 Css NA 2.551 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049009 Css NA 6.302 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049009 Css NA 1.859 mg/L PBTK NA 50% Rat Human -DTXSID7049009 Css NA 3.961 mg/L PBTK NA 95% Rat Human -DTXSID7049051 Clint NA 15.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049051 Fup NA 0.0487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049051 Vd NA 1.23 L/kg 1compartment NA NA Human Human +DTXSID7049009 Vd NA 0.3758 L/kg 1compartment NA NA Rat Human +DTXSID7049009 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7049009 TK.Half.Life NA 3.781 hours 1compartment NA NA Rat Human +DTXSID7049009 Css NA 0.05456 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049009 Css NA 0.326 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049009 Css NA 0.03475 mg/L PBTK NA 50% Rat Human +DTXSID7049009 Css NA 0.1964 mg/L PBTK NA 95% Rat Human +DTXSID7049051 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049051 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049051 Vd NA 0.8528 L/kg 1compartment NA NA Human Human DTXSID7049051 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049051 TK.Half.Life NA 4.906 hours 1compartment NA NA Human Human -DTXSID7049051 Css NA 0.513 mg/L 3compartmentss NA 50% Human Human -DTXSID7049051 Css NA 4.807 mg/L 3compartmentss NA 95% Human Human -DTXSID7049051 Css NA 0.3618 mg/L PBTK NA 50% Human Human -DTXSID7049051 Css NA 3.07 mg/L PBTK NA 95% Human Human -DTXSID7049051 Clint NA 15.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049051 Fup NA 0.0487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049051 Vd NA 1.202 L/kg 1compartment NA NA Rat Human +DTXSID7049051 TK.Half.Life NA 3.039 hours 1compartment NA NA Human Human +DTXSID7049051 Css NA 0.2936 mg/L 3compartmentss NA 50% Human Human +DTXSID7049051 Css NA 1.774 mg/L 3compartmentss NA 95% Human Human +DTXSID7049051 Css NA 0.2114 mg/L PBTK NA 50% Human Human +DTXSID7049051 Css NA 1.167 mg/L PBTK NA 95% Human Human +DTXSID7049051 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049051 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049051 Vd NA 0.84 L/kg 1compartment NA NA Rat Human DTXSID7049051 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049051 TK.Half.Life NA 3.033 hours 1compartment NA NA Rat Human -DTXSID7049051 Css NA 0.2878 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049051 Css NA 2.044 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049051 Css NA 0.1918 mg/L PBTK NA 50% Rat Human -DTXSID7049051 Css NA 1.238 mg/L PBTK NA 95% Rat Human -DTXSID7049053 Clint NA 115.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049053 Fup NA 0.7452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049053 Vd NA 3.388 L/kg 1compartment NA NA Human Human +DTXSID7049051 TK.Half.Life NA 1.775 hours 1compartment NA NA Rat Human +DTXSID7049051 Css NA 0.01294 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049051 Css NA 0.09276 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049051 Css NA 0.00929 mg/L PBTK NA 50% Rat Human +DTXSID7049051 Css NA 0.06028 mg/L PBTK NA 95% Rat Human +DTXSID7049053 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049053 Fup 0.511 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049053 Vd NA 1.945 L/kg 1compartment NA NA Human Human DTXSID7049053 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049053 TK.Half.Life NA 1.469 hours 1compartment NA NA Human Human -DTXSID7049053 Css NA 0.003949 mg/L 3compartmentss NA 50% Human Human -DTXSID7049053 Css NA 0.04943 mg/L 3compartmentss NA 95% Human Human -DTXSID7049053 Css NA 0.004746 mg/L PBTK NA 50% Human Human -DTXSID7049053 Css NA 0.04502 mg/L PBTK NA 95% Human Human -DTXSID7049053 Clint NA 115.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049053 Fup NA 0.7452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049053 Vd NA 3.453 L/kg 1compartment NA NA Rat Human +DTXSID7049053 TK.Half.Life NA 3.04 hours 1compartment NA NA Human Human +DTXSID7049053 Css NA 0.1022 mg/L 3compartmentss NA 50% Human Human +DTXSID7049053 Css NA 0.851 mg/L 3compartmentss NA 95% Human Human +DTXSID7049053 Css NA 0.09792 mg/L PBTK NA 50% Human Human +DTXSID7049053 Css NA 0.6372 mg/L PBTK NA 95% Human Human +DTXSID7049053 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049053 Fup 0.511 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049053 Vd NA 1.966 L/kg 1compartment NA NA Rat Human DTXSID7049053 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049053 TK.Half.Life NA 0.6822 hours 1compartment NA NA Rat Human -DTXSID7049053 Css NA 0.00195 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049053 Css NA 0.02304 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049053 Css NA 0.00244 mg/L PBTK NA 50% Rat Human -DTXSID7049053 Css NA 0.01958 mg/L PBTK NA 95% Rat Human -DTXSID7049055 Clint NA 45.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049055 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049055 Vd NA 3.147 L/kg 1compartment NA NA Human Human +DTXSID7049053 TK.Half.Life NA 1.727 hours 1compartment NA NA Rat Human +DTXSID7049053 Css NA 0.01138 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049053 Css NA 0.08091 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049053 Css NA 0.01128 mg/L PBTK NA 50% Rat Human +DTXSID7049053 Css NA 0.05709 mg/L PBTK NA 95% Rat Human +DTXSID7049055 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049055 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049055 Vd NA 0.3582 L/kg 1compartment NA NA Human Human DTXSID7049055 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049055 TK.Half.Life NA 7.574 hours 1compartment NA NA Human Human -DTXSID7049055 Css NA 0.2015 mg/L 3compartmentss NA 50% Human Human -DTXSID7049055 Css NA 1.629 mg/L 3compartmentss NA 95% Human Human -DTXSID7049055 Css NA 0.1468 mg/L PBTK NA 50% Human Human -DTXSID7049055 Css NA 1.133 mg/L PBTK NA 95% Human Human -DTXSID7049055 Clint NA 45.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049055 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049055 Vd NA 2.387 L/kg 1compartment NA NA Rat Human +DTXSID7049055 TK.Half.Life NA 0.9872 hours 1compartment NA NA Human Human +DTXSID7049055 Css NA 0.2599 mg/L 3compartmentss NA 50% Human Human +DTXSID7049055 Css NA 1.532 mg/L 3compartmentss NA 95% Human Human +DTXSID7049055 Css NA 0.1726 mg/L PBTK NA 50% Human Human +DTXSID7049055 Css NA 0.9639 mg/L PBTK NA 95% Human Human +DTXSID7049055 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049055 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049055 Vd NA 0.377 L/kg 1compartment NA NA Rat Human DTXSID7049055 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049055 TK.Half.Life NA 1.486 hours 1compartment NA NA Rat Human -DTXSID7049055 Css NA 0.1086 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049055 Css NA 0.7326 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049055 Css NA 0.07681 mg/L PBTK NA 50% Rat Human -DTXSID7049055 Css NA 0.503 mg/L PBTK NA 95% Rat Human -DTXSID7049057 Clint NA 15.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049057 Fup NA 0.3507 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049057 Vd NA 3.586 L/kg 1compartment NA NA Human Human +DTXSID7049055 TK.Half.Life NA 0.596 hours 1compartment NA NA Rat Human +DTXSID7049055 Css NA 0.03093 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049055 Css NA 0.1386 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049055 Css NA 0.02019 mg/L PBTK NA 50% Rat Human +DTXSID7049055 Css NA 0.08428 mg/L PBTK NA 95% Rat Human +DTXSID7049057 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049057 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049057 Vd NA 3.694 L/kg 1compartment NA NA Human Human DTXSID7049057 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049057 TK.Half.Life NA 4.216 hours 1compartment NA NA Human Human -DTXSID7049057 Css NA 0.05812 mg/L 3compartmentss NA 50% Human Human -DTXSID7049057 Css NA 0.4645 mg/L 3compartmentss NA 95% Human Human -DTXSID7049057 Css NA 0.06477 mg/L PBTK NA 50% Human Human -DTXSID7049057 Css NA 0.4207 mg/L PBTK NA 95% Human Human -DTXSID7049057 Clint NA 15.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049057 Fup NA 0.3507 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049057 Vd NA 3.505 L/kg 1compartment NA NA Rat Human +DTXSID7049057 TK.Half.Life NA 9.759 hours 1compartment NA NA Human Human +DTXSID7049057 Css NA 0.176 mg/L 3compartmentss NA 50% Human Human +DTXSID7049057 Css NA 1.217 mg/L 3compartmentss NA 95% Human Human +DTXSID7049057 Css NA 0.1865 mg/L PBTK NA 50% Human Human +DTXSID7049057 Css NA 1.062 mg/L PBTK NA 95% Human Human +DTXSID7049057 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049057 Fup 0.294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049057 Vd NA 3.511 L/kg 1compartment NA NA Rat Human DTXSID7049057 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049057 TK.Half.Life NA 2.135 hours 1compartment NA NA Rat Human -DTXSID7049057 Css NA 0.03007 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049057 Css NA 0.1848 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049057 Css NA 0.0337 mg/L PBTK NA 50% Rat Human -DTXSID7049057 Css NA 0.1605 mg/L PBTK NA 95% Rat Human -DTXSID7049059 Clint NA 35.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID7049057 TK.Half.Life NA 4.483 hours 1compartment NA NA Rat Human +DTXSID7049057 Css NA 0.02024 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049057 Css NA 0.1055 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049057 Css NA 0.02244 mg/L PBTK NA 50% Rat Human +DTXSID7049057 Css NA 0.09173 mg/L PBTK NA 95% Rat Human +DTXSID7049059 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID7049059 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID7049059 Vd NA 1.54 L/kg 1compartment NA NA Human Human +DTXSID7049059 Vd NA 1.581 L/kg 1compartment NA NA Human Human DTXSID7049059 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049059 TK.Half.Life NA 1.731 hours 1compartment NA NA Human Human -DTXSID7049059 Css NA 0.0503 mg/L 3compartmentss NA 50% Human Human -DTXSID7049059 Css NA 0.3896 mg/L 3compartmentss NA 95% Human Human -DTXSID7049059 Css NA 0.04042 mg/L PBTK NA 50% Human Human -DTXSID7049059 Css NA 0.2754 mg/L PBTK NA 95% Human Human -DTXSID7049059 Clint NA 35.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID7049059 TK.Half.Life NA 4.738 hours 1compartment NA NA Human Human +DTXSID7049059 Css NA 0.218 mg/L 3compartmentss NA 50% Human Human +DTXSID7049059 Css NA 1.547 mg/L 3compartmentss NA 95% Human Human +DTXSID7049059 Css NA 0.1754 mg/L PBTK NA 50% Human Human +DTXSID7049059 Css NA 1.075 mg/L PBTK NA 95% Human Human +DTXSID7049059 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID7049059 Fup 0.24 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID7049059 Vd NA 1.476 L/kg 1compartment NA NA Rat Human +DTXSID7049059 Vd NA 1.511 L/kg 1compartment NA NA Rat Human DTXSID7049059 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049059 TK.Half.Life NA 0.8634 hours 1compartment NA NA Rat Human -DTXSID7049059 Css NA 0.02764 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049059 Css NA 0.1616 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049059 Css NA 0.02158 mg/L PBTK NA 50% Rat Human -DTXSID7049059 Css NA 0.1124 mg/L PBTK NA 95% Rat Human -DTXSID7049211 Clint NA 11.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049211 Fup NA 0.0477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049211 Vd NA 1.639 L/kg 1compartment NA NA Human Human -DTXSID7049211 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7049211 TK.Half.Life NA 14.23 hours 1compartment NA NA Human Human -DTXSID7049211 Css NA 1.31 mg/L 3compartmentss NA 50% Human Human -DTXSID7049211 Css NA 9.505 mg/L 3compartmentss NA 95% Human Human -DTXSID7049211 Css NA 0.8362 mg/L PBTK NA 50% Human Human -DTXSID7049211 Css NA 5.746 mg/L PBTK NA 95% Human Human -DTXSID7049211 Clint NA 11.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049211 Fup NA 0.0477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049211 Vd NA 1.227 L/kg 1compartment NA NA Rat Human +DTXSID7049059 TK.Half.Life NA 2.581 hours 1compartment NA NA Rat Human +DTXSID7049059 Css NA 0.009796 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049059 Css NA 0.07147 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049059 Css NA 0.007901 mg/L PBTK NA 50% Rat Human +DTXSID7049059 Css NA 0.05004 mg/L PBTK NA 95% Rat Human +DTXSID7049211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049211 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049211 Vd NA 1.019 L/kg 1compartment NA NA Human Human +DTXSID7049211 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7049211 TK.Half.Life NA 9.756 hours 1compartment NA NA Human Human +DTXSID7049211 Css NA 1.55 mg/L 3compartmentss NA 50% Human Human +DTXSID7049211 Css NA 14.6 mg/L 3compartmentss NA 95% Human Human +DTXSID7049211 Css NA 0.9478 mg/L PBTK NA 50% Human Human +DTXSID7049211 Css NA 8.722 mg/L PBTK NA 95% Human Human +DTXSID7049211 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049211 Fup 0.0181 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049211 Vd NA 0.7564 L/kg 1compartment NA NA Rat Human DTXSID7049211 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049211 TK.Half.Life NA 5.2 hours 1compartment NA NA Rat Human -DTXSID7049211 Css NA 0.7228 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049211 Css NA 3.884 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049211 Css NA 0.4358 mg/L PBTK NA 50% Rat Human -DTXSID7049211 Css NA 2.224 mg/L PBTK NA 95% Rat Human -DTXSID7049213 Clint NA 4.221 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049213 Fup NA 0.0616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049213 Vd NA 2.109 L/kg 1compartment NA NA Human Human -DTXSID7049213 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID7049213 TK.Half.Life NA 42.63 hours 1compartment NA NA Human Human -DTXSID7049213 Css NA 3.018 mg/L 3compartmentss NA 50% Human Human -DTXSID7049213 Css NA 16.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7049213 Css NA 1.994 mg/L PBTK NA 50% Human Human -DTXSID7049213 Css NA 10.61 mg/L PBTK NA 95% Human Human -DTXSID7049213 Clint NA 4.221 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049213 Fup NA 0.0616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049213 Vd NA 1.584 L/kg 1compartment NA NA Rat Human -DTXSID7049213 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7049213 TK.Half.Life NA 12.4 hours 1compartment NA NA Rat Human -DTXSID7049213 Css NA 1.534 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049213 Css NA 6.291 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049213 Css NA 0.9654 mg/L PBTK NA 50% Rat Human -DTXSID7049213 Css NA 3.708 mg/L PBTK NA 95% Rat Human -DTXSID7049215 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049215 Fup NA 0.8621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049215 Vd NA 1.177 L/kg 1compartment NA NA Human Human +DTXSID7049211 TK.Half.Life NA 4.252 hours 1compartment NA NA Rat Human +DTXSID7049211 Css NA 0.2012 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049211 Css NA 1.539 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049211 Css NA 0.1185 mg/L PBTK NA 50% Rat Human +DTXSID7049211 Css NA 0.8817 mg/L PBTK NA 95% Rat Human +DTXSID7049213 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049213 Fup 0.0389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049213 Vd NA 2.077 L/kg 1compartment NA NA Human Human +DTXSID7049213 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7049213 TK.Half.Life NA 13.88 hours 1compartment NA NA Human Human +DTXSID7049213 Css NA 0.9276 mg/L 3compartmentss NA 50% Human Human +DTXSID7049213 Css NA 7.27 mg/L 3compartmentss NA 95% Human Human +DTXSID7049213 Css NA 0.606 mg/L PBTK NA 50% Human Human +DTXSID7049213 Css NA 4.509 mg/L PBTK NA 95% Human Human +DTXSID7049213 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049213 Fup 0.0389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049213 Vd NA 1.552 L/kg 1compartment NA NA Rat Human +DTXSID7049213 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7049213 TK.Half.Life NA 4.357 hours 1compartment NA NA Rat Human +DTXSID7049213 Css NA 0.1188 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049213 Css NA 0.7596 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049213 Css NA 0.07606 mg/L PBTK NA 50% Rat Human +DTXSID7049213 Css NA 0.4628 mg/L PBTK NA 95% Rat Human +DTXSID7049215 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049215 Fup 0.63 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049215 Vd NA 1.571 L/kg 1compartment NA NA Human Human DTXSID7049215 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049215 TK.Half.Life NA 9.244 hours 1compartment NA NA Human Human -DTXSID7049215 Css NA 0.8752 mg/L 3compartmentss NA 50% Human Human -DTXSID7049215 Css NA 5.345 mg/L 3compartmentss NA 95% Human Human -DTXSID7049215 Css NA 0.7924 mg/L PBTK NA 50% Human Human -DTXSID7049215 Css NA 3.575 mg/L PBTK NA 95% Human Human -DTXSID7049215 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049215 Fup NA 0.8621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049215 Vd NA 1.118 L/kg 1compartment NA NA Rat Human +DTXSID7049215 TK.Half.Life NA 1.394 hours 1compartment NA NA Human Human +DTXSID7049215 Css NA 0.02627 mg/L 3compartmentss NA 50% Human Human +DTXSID7049215 Css NA 0.3079 mg/L 3compartmentss NA 95% Human Human +DTXSID7049215 Css NA 0.02279 mg/L PBTK NA 50% Human Human +DTXSID7049215 Css NA 0.2188 mg/L PBTK NA 95% Human Human +DTXSID7049215 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049215 Fup 0.63 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049215 Vd NA 1.349 L/kg 1compartment NA NA Rat Human DTXSID7049215 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049215 TK.Half.Life NA 2.892 hours 1compartment NA NA Rat Human -DTXSID7049215 Css NA 0.2246 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049215 Css NA 1.401 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049215 Css NA 0.1978 mg/L PBTK NA 50% Rat Human -DTXSID7049215 Css NA 0.8657 mg/L PBTK NA 95% Rat Human -DTXSID7049261 Clint NA 0.9826 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049261 Fup NA 0.7006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049261 Vd NA 0.9924 L/kg 1compartment NA NA Human Human +DTXSID7049215 TK.Half.Life NA 0.5677 hours 1compartment NA NA Rat Human +DTXSID7049215 Css NA 0.0009294 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049215 Css NA 0.01237 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049215 Css NA 0.0008093 mg/L PBTK NA 50% Rat Human +DTXSID7049215 Css NA 0.008487 mg/L PBTK NA 95% Rat Human +DTXSID7049261 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049261 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049261 Vd NA 0.9127 L/kg 1compartment NA NA Human Human DTXSID7049261 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049261 TK.Half.Life NA 3.798 hours 1compartment NA NA Human Human -DTXSID7049261 Css NA 0.4024 mg/L 3compartmentss NA 50% Human Human -DTXSID7049261 Css NA 2.734 mg/L 3compartmentss NA 95% Human Human -DTXSID7049261 Css NA 0.345 mg/L PBTK NA 50% Human Human -DTXSID7049261 Css NA 1.789 mg/L PBTK NA 95% Human Human -DTXSID7049261 Clint NA 0.9826 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049261 Fup NA 0.7006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049261 Vd NA 0.9508 L/kg 1compartment NA NA Rat Human +DTXSID7049261 TK.Half.Life NA 0.8729 hours 1compartment NA NA Human Human +DTXSID7049261 Css NA 0.03666 mg/L 3compartmentss NA 50% Human Human +DTXSID7049261 Css NA 0.3354 mg/L 3compartmentss NA 95% Human Human +DTXSID7049261 Css NA 0.02952 mg/L PBTK NA 50% Human Human +DTXSID7049261 Css NA 0.237 mg/L PBTK NA 95% Human Human +DTXSID7049261 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049261 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049261 Vd NA 0.8554 L/kg 1compartment NA NA Rat Human DTXSID7049261 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049261 TK.Half.Life NA 1.725 hours 1compartment NA NA Rat Human -DTXSID7049261 Css NA 0.1521 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049261 Css NA 1.035 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049261 Css NA 0.1271 mg/L PBTK NA 50% Rat Human -DTXSID7049261 Css NA 0.6268 mg/L PBTK NA 95% Rat Human -DTXSID7049265 Clint NA 32.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049265 Fup NA 0.3231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049265 Vd NA 1.533 L/kg 1compartment NA NA Human Human +DTXSID7049261 TK.Half.Life NA 0.4092 hours 1compartment NA NA Rat Human +DTXSID7049261 Css NA 0.00445 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049261 Css NA 0.03446 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049261 Css NA 0.003626 mg/L PBTK NA 50% Rat Human +DTXSID7049261 Css NA 0.02329 mg/L PBTK NA 95% Rat Human +DTXSID7049265 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049265 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049265 Vd NA 1.063 L/kg 1compartment NA NA Human Human DTXSID7049265 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049265 TK.Half.Life NA 1.76 hours 1compartment NA NA Human Human -DTXSID7049265 Css NA 0.05298 mg/L 3compartmentss NA 50% Human Human -DTXSID7049265 Css NA 0.3968 mg/L 3compartmentss NA 95% Human Human -DTXSID7049265 Css NA 0.04003 mg/L PBTK NA 50% Human Human -DTXSID7049265 Css NA 0.2766 mg/L PBTK NA 95% Human Human -DTXSID7049265 Clint NA 32.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049265 Fup NA 0.3231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049265 Vd NA 1.228 L/kg 1compartment NA NA Rat Human +DTXSID7049265 TK.Half.Life NA 4.888 hours 1compartment NA NA Human Human +DTXSID7049265 Css NA 0.5406 mg/L 3compartmentss NA 50% Human Human +DTXSID7049265 Css NA 3.514 mg/L 3compartmentss NA 95% Human Human +DTXSID7049265 Css NA 0.3631 mg/L PBTK NA 50% Human Human +DTXSID7049265 Css NA 2.22 mg/L PBTK NA 95% Human Human +DTXSID7049265 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049265 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049265 Vd NA 0.8457 L/kg 1compartment NA NA Rat Human DTXSID7049265 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049265 TK.Half.Life NA 0.6684 hours 1compartment NA NA Rat Human -DTXSID7049265 Css NA 0.02878 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049265 Css NA 0.1636 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049265 Css NA 0.02105 mg/L PBTK NA 50% Rat Human -DTXSID7049265 Css NA 0.1094 mg/L PBTK NA 95% Rat Human -DTXSID7049340 Clint NA 83.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049340 Fup NA 0.0211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049340 Vd NA 3.117 L/kg 1compartment NA NA Human Human -DTXSID7049340 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7049340 TK.Half.Life NA 25.24 hours 1compartment NA NA Human Human -DTXSID7049340 Css NA 0.9038 mg/L 3compartmentss NA 50% Human Human -DTXSID7049340 Css NA 5.472 mg/L 3compartmentss NA 95% Human Human -DTXSID7049340 Css NA 0.629 mg/L PBTK NA 50% Human Human -DTXSID7049340 Css NA 3.688 mg/L PBTK NA 95% Human Human -DTXSID7049340 Clint NA 83.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049340 Fup NA 0.0211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049340 Vd NA 2.335 L/kg 1compartment NA NA Rat Human -DTXSID7049340 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7049340 TK.Half.Life NA 3.777 hours 1compartment NA NA Rat Human -DTXSID7049340 Css NA 0.5135 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049340 Css NA 2.334 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049340 Css NA 0.3398 mg/L PBTK NA 50% Rat Human -DTXSID7049340 Css NA 1.511 mg/L PBTK NA 95% Rat Human -DTXSID7049344 Clint NA 2.972 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049344 Fup NA 0.1539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049344 Vd NA 1.78 L/kg 1compartment NA NA Human Human -DTXSID7049344 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7049344 TK.Half.Life NA 18.17 hours 1compartment NA NA Human Human -DTXSID7049344 Css NA 1.312 mg/L 3compartmentss NA 50% Human Human -DTXSID7049344 Css NA 6.991 mg/L 3compartmentss NA 95% Human Human -DTXSID7049344 Css NA 0.9192 mg/L PBTK NA 50% Human Human -DTXSID7049344 Css NA 4.459 mg/L PBTK NA 95% Human Human -DTXSID7049344 Clint NA 2.972 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049344 Fup NA 0.1539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049344 Vd NA 1.37 L/kg 1compartment NA NA Rat Human +DTXSID7049265 TK.Half.Life NA 2.135 hours 1compartment NA NA Rat Human +DTXSID7049265 Css NA 0.06566 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049265 Css NA 0.3121 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049265 Css NA 0.04324 mg/L PBTK NA 50% Rat Human +DTXSID7049265 Css NA 0.1892 mg/L PBTK NA 95% Rat Human +DTXSID7049340 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049340 Fup 0.0167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049340 Vd NA 12.27 L/kg 1compartment NA NA Human Human +DTXSID7049340 Days.Css NA 78 Days PBTK NA NA Human Human +DTXSID7049340 TK.Half.Life NA 365.4 hours 1compartment NA NA Human Human +DTXSID7049340 Css NA 1.721 mg/L 3compartmentss NA 50% Human Human +DTXSID7049340 Css NA 10.7 mg/L 3compartmentss NA 95% Human Human +DTXSID7049340 Css NA 2.378 mg/L PBTK NA 50% Human Human +DTXSID7049340 Css NA 14.31 mg/L PBTK NA 95% Human Human +DTXSID7049340 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049340 Fup 0.0167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049340 Vd NA 9.751 L/kg 1compartment NA NA Rat Human +DTXSID7049340 Days.Css NA 47 Days PBTK NA NA Rat Human +DTXSID7049340 TK.Half.Life NA 50.85 hours 1compartment NA NA Rat Human +DTXSID7049340 Css NA 0.2119 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049340 Css NA 1.061 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049340 Css NA 0.3079 mg/L PBTK NA 50% Rat Human +DTXSID7049340 Css NA 1.621 mg/L PBTK NA 95% Rat Human +DTXSID7049344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049344 Fup 0.0831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049344 Vd NA 1.626 L/kg 1compartment NA NA Human Human +DTXSID7049344 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7049344 TK.Half.Life NA 5.436 hours 1compartment NA NA Human Human +DTXSID7049344 Css NA 0.3865 mg/L 3compartmentss NA 50% Human Human +DTXSID7049344 Css NA 2.882 mg/L 3compartmentss NA 95% Human Human +DTXSID7049344 Css NA 0.2546 mg/L PBTK NA 50% Human Human +DTXSID7049344 Css NA 1.793 mg/L PBTK NA 95% Human Human +DTXSID7049344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049344 Fup 0.0831 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049344 Vd NA 1.234 L/kg 1compartment NA NA Rat Human DTXSID7049344 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049344 TK.Half.Life NA 6.075 hours 1compartment NA NA Rat Human -DTXSID7049344 Css NA 0.6429 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049344 Css NA 2.42 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049344 Css NA 0.4267 mg/L PBTK NA 50% Rat Human -DTXSID7049344 Css NA 1.449 mg/L PBTK NA 95% Rat Human -DTXSID7049346 Clint NA 3.656 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049346 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049346 Vd NA 1.391 L/kg 1compartment NA NA Human Human -DTXSID7049346 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7049346 TK.Half.Life NA 22.59 hours 1compartment NA NA Human Human -DTXSID7049346 Css NA 2.386 mg/L 3compartmentss NA 50% Human Human -DTXSID7049346 Css NA 13.03 mg/L 3compartmentss NA 95% Human Human -DTXSID7049346 Css NA 1.545 mg/L PBTK NA 50% Human Human -DTXSID7049346 Css NA 8.08 mg/L PBTK NA 95% Human Human -DTXSID7049346 Clint NA 3.656 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049346 Fup NA 0.0661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049346 Vd NA 1.055 L/kg 1compartment NA NA Rat Human -DTXSID7049346 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7049346 TK.Half.Life NA 8.531 hours 1compartment NA NA Rat Human -DTXSID7049346 Css NA 1.209 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049346 Css NA 4.514 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049346 Css NA 0.7382 mg/L PBTK NA 50% Rat Human -DTXSID7049346 Css NA 2.591 mg/L PBTK NA 95% Rat Human -DTXSID7049392 Clint NA 3.205 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049392 Fup NA 0.1968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049392 Vd NA 2.123 L/kg 1compartment NA NA Human Human -DTXSID7049392 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7049392 TK.Half.Life NA 19.49 hours 1compartment NA NA Human Human -DTXSID7049392 Css NA 1.032 mg/L 3compartmentss NA 50% Human Human -DTXSID7049392 Css NA 4.743 mg/L 3compartmentss NA 95% Human Human -DTXSID7049392 Css NA 0.7502 mg/L PBTK NA 50% Human Human -DTXSID7049392 Css NA 3.228 mg/L PBTK NA 95% Human Human -DTXSID7049392 Clint NA 3.205 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049392 Fup NA 0.1968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049392 Vd NA 1.631 L/kg 1compartment NA NA Rat Human +DTXSID7049344 TK.Half.Life NA 2.031 hours 1compartment NA NA Rat Human +DTXSID7049344 Css NA 0.05026 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049344 Css NA 0.273 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049344 Css NA 0.03247 mg/L PBTK NA 50% Rat Human +DTXSID7049344 Css NA 0.1678 mg/L PBTK NA 95% Rat Human +DTXSID7049346 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049346 Fup 0.0881 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049346 Vd NA 1.582 L/kg 1compartment NA NA Human Human +DTXSID7049346 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7049346 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human +DTXSID7049346 Css NA 0.357 mg/L 3compartmentss NA 50% Human Human +DTXSID7049346 Css NA 2.633 mg/L 3compartmentss NA 95% Human Human +DTXSID7049346 Css NA 0.2354 mg/L PBTK NA 50% Human Human +DTXSID7049346 Css NA 1.649 mg/L PBTK NA 95% Human Human +DTXSID7049346 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049346 Fup 0.0881 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049346 Vd NA 1.203 L/kg 1compartment NA NA Rat Human +DTXSID7049346 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7049346 TK.Half.Life NA 1.899 hours 1compartment NA NA Rat Human +DTXSID7049346 Css NA 0.04637 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049346 Css NA 0.2709 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049346 Css NA 0.02994 mg/L PBTK NA 50% Rat Human +DTXSID7049346 Css NA 0.1646 mg/L PBTK NA 95% Rat Human +DTXSID7049392 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049392 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049392 Vd NA 1.68 L/kg 1compartment NA NA Human Human +DTXSID7049392 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7049392 TK.Half.Life NA 4.3 hours 1compartment NA NA Human Human +DTXSID7049392 Css NA 0.2529 mg/L 3compartmentss NA 50% Human Human +DTXSID7049392 Css NA 1.908 mg/L 3compartmentss NA 95% Human Human +DTXSID7049392 Css NA 0.1722 mg/L PBTK NA 50% Human Human +DTXSID7049392 Css NA 1.218 mg/L PBTK NA 95% Human Human +DTXSID7049392 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049392 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049392 Vd NA 1.288 L/kg 1compartment NA NA Rat Human DTXSID7049392 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049392 TK.Half.Life NA 5.743 hours 1compartment NA NA Rat Human -DTXSID7049392 Css NA 0.5015 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049392 Css NA 1.692 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049392 Css NA 0.3503 mg/L PBTK NA 50% Rat Human -DTXSID7049392 Css NA 1.072 mg/L PBTK NA 95% Rat Human -DTXSID7049394 Clint NA 5.915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049394 Fup NA 0.5681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049394 Vd NA 2.673 L/kg 1compartment NA NA Human Human +DTXSID7049392 TK.Half.Life NA 1.591 hours 1compartment NA NA Rat Human +DTXSID7049392 Css NA 0.0331 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049392 Css NA 0.187 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049392 Css NA 0.02211 mg/L PBTK NA 50% Rat Human +DTXSID7049392 Css NA 0.1179 mg/L PBTK NA 95% Rat Human +DTXSID7049394 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049394 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049394 Vd NA 1.54 L/kg 1compartment NA NA Human Human DTXSID7049394 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049394 TK.Half.Life NA 8.976 hours 1compartment NA NA Human Human -DTXSID7049394 Css NA 0.3201 mg/L 3compartmentss NA 50% Human Human -DTXSID7049394 Css NA 1.894 mg/L 3compartmentss NA 95% Human Human -DTXSID7049394 Css NA 0.2563 mg/L PBTK NA 50% Human Human -DTXSID7049394 Css NA 1.346 mg/L PBTK NA 95% Human Human -DTXSID7049394 Clint NA 5.915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049394 Fup NA 0.5681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049394 Vd NA 2.085 L/kg 1compartment NA NA Rat Human +DTXSID7049394 TK.Half.Life NA 2.097 hours 1compartment NA NA Human Human +DTXSID7049394 Css NA 0.0744 mg/L 3compartmentss NA 50% Human Human +DTXSID7049394 Css NA 0.559 mg/L 3compartmentss NA 95% Human Human +DTXSID7049394 Css NA 0.05662 mg/L PBTK NA 50% Human Human +DTXSID7049394 Css NA 0.3855 mg/L PBTK NA 95% Human Human +DTXSID7049394 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049394 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049394 Vd NA 1.245 L/kg 1compartment NA NA Rat Human DTXSID7049394 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049394 TK.Half.Life NA 2.262 hours 1compartment NA NA Rat Human -DTXSID7049394 Css NA 0.1613 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049394 Css NA 0.7383 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049394 Css NA 0.1256 mg/L PBTK NA 50% Rat Human -DTXSID7049394 Css NA 0.5004 mg/L PBTK NA 95% Rat Human -DTXSID7049398 Clint NA 0.1044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049398 Fup NA 0.4359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049398 Vd NA 2.282 L/kg 1compartment NA NA Human Human -DTXSID7049398 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID7049398 TK.Half.Life NA 56.82 hours 1compartment NA NA Human Human -DTXSID7049398 Css NA 2.553 mg/L 3compartmentss NA 50% Human Human -DTXSID7049398 Css NA 9.107 mg/L 3compartmentss NA 95% Human Human -DTXSID7049398 Css NA 2.06 mg/L PBTK NA 50% Human Human -DTXSID7049398 Css NA 6.194 mg/L PBTK NA 95% Human Human -DTXSID7049398 Clint NA 0.1044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049398 Fup NA 0.4359 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049398 Vd NA 1.796 L/kg 1compartment NA NA Rat Human -DTXSID7049398 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7049398 TK.Half.Life NA 10.28 hours 1compartment NA NA Rat Human -DTXSID7049398 Css NA 0.7608 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049398 Css NA 2.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049398 Css NA 0.5924 mg/L PBTK NA 50% Rat Human -DTXSID7049398 Css NA 1.479 mg/L PBTK NA 95% Rat Human -DTXSID7049423 Clint NA 22.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049423 Fup NA 0.6286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049423 Vd NA 1.017 L/kg 1compartment NA NA Human Human +DTXSID7049394 TK.Half.Life NA 0.8242 hours 1compartment NA NA Rat Human +DTXSID7049394 Css NA 0.009422 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049394 Css NA 0.05305 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049394 Css NA 0.007151 mg/L PBTK NA 50% Rat Human +DTXSID7049394 Css NA 0.03666 mg/L PBTK NA 95% Rat Human +DTXSID7049396 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049396 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049396 Vd NA 2.68 L/kg 1compartment NA NA Human Human +DTXSID7049396 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7049396 TK.Half.Life NA 7.445 hours 1compartment NA NA Human Human +DTXSID7049396 Css NA 0.2352 mg/L 3compartmentss NA 50% Human Human +DTXSID7049396 Css NA 1.498 mg/L 3compartmentss NA 95% Human Human +DTXSID7049396 Css NA 0.1716 mg/L PBTK NA 50% Human Human +DTXSID7049396 Css NA 1.038 mg/L PBTK NA 95% Human Human +DTXSID7049396 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049396 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049396 Vd NA 2.04 L/kg 1compartment NA NA Rat Human +DTXSID7049396 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7049396 TK.Half.Life NA 1.88 hours 1compartment NA NA Rat Human +DTXSID7049396 Css NA 0.03014 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049396 Css NA 0.1467 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049396 Css NA 0.02188 mg/L PBTK NA 50% Rat Human +DTXSID7049396 Css NA 0.1024 mg/L PBTK NA 95% Rat Human +DTXSID7049398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049398 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049398 Vd NA 1.622 L/kg 1compartment NA NA Human Human +DTXSID7049398 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7049398 TK.Half.Life NA 3.413 hours 1compartment NA NA Human Human +DTXSID7049398 Css NA 0.1735 mg/L 3compartmentss NA 50% Human Human +DTXSID7049398 Css NA 1.234 mg/L 3compartmentss NA 95% Human Human +DTXSID7049398 Css NA 0.1208 mg/L PBTK NA 50% Human Human +DTXSID7049398 Css NA 0.8336 mg/L PBTK NA 95% Human Human +DTXSID7049398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049398 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049398 Vd NA 1.259 L/kg 1compartment NA NA Rat Human +DTXSID7049398 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7049398 TK.Half.Life NA 1.29 hours 1compartment NA NA Rat Human +DTXSID7049398 Css NA 0.02216 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049398 Css NA 0.1247 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049398 Css NA 0.01531 mg/L PBTK NA 50% Rat Human +DTXSID7049398 Css NA 0.08056 mg/L PBTK NA 95% Rat Human +DTXSID7049423 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049423 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049423 Vd NA 0.6898 L/kg 1compartment NA NA Human Human DTXSID7049423 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049423 TK.Half.Life NA 0.875 hours 1compartment NA NA Human Human -DTXSID7049423 Css NA 0.03315 mg/L 3compartmentss NA 50% Human Human -DTXSID7049423 Css NA 0.3487 mg/L 3compartmentss NA 95% Human Human -DTXSID7049423 Css NA 0.02755 mg/L PBTK NA 50% Human Human -DTXSID7049423 Css NA 0.2453 mg/L PBTK NA 95% Human Human -DTXSID7049423 Clint NA 22.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049423 Fup NA 0.6286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049423 Vd NA 0.9514 L/kg 1compartment NA NA Rat Human +DTXSID7049423 TK.Half.Life NA 0.8683 hours 1compartment NA NA Human Human +DTXSID7049423 Css NA 0.06144 mg/L 3compartmentss NA 50% Human Human +DTXSID7049423 Css NA 0.4953 mg/L 3compartmentss NA 95% Human Human +DTXSID7049423 Css NA 0.04444 mg/L PBTK NA 50% Human Human +DTXSID7049423 Css NA 0.3251 mg/L PBTK NA 95% Human Human +DTXSID7049423 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049423 Fup 0.322 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049423 Vd NA 0.6419 L/kg 1compartment NA NA Rat Human DTXSID7049423 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049423 TK.Half.Life NA 0.4016 hours 1compartment NA NA Rat Human -DTXSID7049423 Css NA 0.0169 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049423 Css NA 0.1592 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049423 Css NA 0.01382 mg/L PBTK NA 50% Rat Human -DTXSID7049423 Css NA 0.1025 mg/L PBTK NA 95% Rat Human +DTXSID7049423 TK.Half.Life NA 0.4237 hours 1compartment NA NA Rat Human +DTXSID7049423 Css NA 0.007798 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049423 Css NA 0.04696 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049423 Css NA 0.005603 mg/L PBTK NA 50% Rat Human +DTXSID7049423 Css NA 0.03089 mg/L PBTK NA 95% Rat Human DTXSID7049425 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7049425 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049425 Vd NA 0.9006 L/kg 1compartment NA NA Human Human +DTXSID7049425 Vd NA 0.9366 L/kg 1compartment NA NA Human Human DTXSID7049425 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049425 TK.Half.Life NA 5.849 hours 1compartment NA NA Human Human -DTXSID7049425 Css NA 0.7987 mg/L 3compartmentss NA 50% Human Human -DTXSID7049425 Css NA 5.754 mg/L 3compartmentss NA 95% Human Human -DTXSID7049425 Css NA 0.6985 mg/L PBTK NA 50% Human Human -DTXSID7049425 Css NA 3.736 mg/L PBTK NA 95% Human Human +DTXSID7049425 TK.Half.Life NA 6.102 hours 1compartment NA NA Human Human +DTXSID7049425 Css NA 0.6717 mg/L 3compartmentss NA 50% Human Human +DTXSID7049425 Css NA 4.968 mg/L 3compartmentss NA 95% Human Human +DTXSID7049425 Css NA 0.592 mg/L PBTK NA 50% Human Human +DTXSID7049425 Css NA 3.254 mg/L PBTK NA 95% Human Human DTXSID7049425 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7049425 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049425 Vd NA 0.9209 L/kg 1compartment NA NA Rat Human +DTXSID7049425 Vd NA 0.9508 L/kg 1compartment NA NA Rat Human DTXSID7049425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049425 TK.Half.Life NA 2.033 hours 1compartment NA NA Rat Human -DTXSID7049425 Css NA 0.2015 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049425 Css NA 1.283 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049425 Css NA 0.1725 mg/L PBTK NA 50% Rat Human -DTXSID7049425 Css NA 0.7823 mg/L PBTK NA 95% Rat Human -DTXSID7049427 Clint NA 5.817 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049427 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049427 Vd NA 0.3278 L/kg 1compartment NA NA Human Human -DTXSID7049427 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7049427 TK.Half.Life NA 30.05 hours 1compartment NA NA Human Human -DTXSID7049427 Css NA 17.48 mg/L 3compartmentss NA 50% Human Human -DTXSID7049427 Css NA 143.8 mg/L 3compartmentss NA 95% Human Human -DTXSID7049427 Css NA 10.28 mg/L PBTK NA 50% Human Human -DTXSID7049427 Css NA 83.01 mg/L PBTK NA 95% Human Human -DTXSID7049427 Clint NA 5.817 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049427 Fup NA 0.006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049427 Vd NA 0.264 L/kg 1compartment NA NA Rat Human -DTXSID7049427 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7049427 TK.Half.Life NA 15.39 hours 1compartment NA NA Rat Human -DTXSID7049427 Css NA 9.224 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049427 Css NA 64.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049427 Css NA 5.037 mg/L PBTK NA 50% Rat Human -DTXSID7049427 Css NA 35.07 mg/L PBTK NA 95% Rat Human -DTXSID7049429 Clint NA 2.812 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049429 Fup NA 0.1853 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7049429 Vd NA 1.016 L/kg 1compartment NA NA Human Human +DTXSID7049425 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human +DTXSID7049425 Css NA 0.01216 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049425 Css NA 0.09511 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049425 Css NA 0.01043 mg/L PBTK NA 50% Rat Human +DTXSID7049425 Css NA 0.06445 mg/L PBTK NA 95% Rat Human +DTXSID7049427 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049427 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049427 Vd NA 0.2689 L/kg 1compartment NA NA Human Human +DTXSID7049427 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7049427 TK.Half.Life NA 2.107 hours 1compartment NA NA Human Human +DTXSID7049427 Css NA 1.275 mg/L 3compartmentss NA 50% Human Human +DTXSID7049427 Css NA 12.63 mg/L 3compartmentss NA 95% Human Human +DTXSID7049427 Css NA 0.7734 mg/L PBTK NA 50% Human Human +DTXSID7049427 Css NA 7.473 mg/L PBTK NA 95% Human Human +DTXSID7049427 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049427 Fup 0.0251 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049427 Vd NA 0.2598 L/kg 1compartment NA NA Rat Human +DTXSID7049427 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7049427 TK.Half.Life NA 1.326 hours 1compartment NA NA Rat Human +DTXSID7049427 Css NA 0.1671 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049427 Css NA 1.267 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049427 Css NA 0.09767 mg/L PBTK NA 50% Rat Human +DTXSID7049427 Css NA 0.7278 mg/L PBTK NA 95% Rat Human +DTXSID7049429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049429 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7049429 Vd NA 0.8441 L/kg 1compartment NA NA Human Human DTXSID7049429 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7049429 TK.Half.Life NA 7.21 hours 1compartment NA NA Human Human -DTXSID7049429 Css NA 0.8278 mg/L 3compartmentss NA 50% Human Human -DTXSID7049429 Css NA 4.031 mg/L 3compartmentss NA 95% Human Human -DTXSID7049429 Css NA 0.5772 mg/L PBTK NA 50% Human Human -DTXSID7049429 Css NA 2.603 mg/L PBTK NA 95% Human Human -DTXSID7049429 Clint NA 2.812 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049429 Fup NA 0.1853 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7049429 Vd NA 0.8326 L/kg 1compartment NA NA Rat Human +DTXSID7049429 TK.Half.Life NA 1.825 hours 1compartment NA NA Human Human +DTXSID7049429 Css NA 0.2032 mg/L 3compartmentss NA 50% Human Human +DTXSID7049429 Css NA 1.708 mg/L 3compartmentss NA 95% Human Human +DTXSID7049429 Css NA 0.133 mg/L PBTK NA 50% Human Human +DTXSID7049429 Css NA 1.056 mg/L PBTK NA 95% Human Human +DTXSID7049429 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049429 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7049429 Vd NA 0.6896 L/kg 1compartment NA NA Rat Human DTXSID7049429 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7049429 TK.Half.Life NA 3.129 hours 1compartment NA NA Rat Human -DTXSID7049429 Css NA 0.3914 mg/L 3compartmentss NA 50% Rat Human -DTXSID7049429 Css NA 1.439 mg/L 3compartmentss NA 95% Rat Human -DTXSID7049429 Css NA 0.2593 mg/L PBTK NA 50% Rat Human -DTXSID7049429 Css NA 0.8598 mg/L PBTK NA 95% Rat Human -DTXSID7051474 Clint NA 316.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7051474 Fup NA 0.0667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7051474 Vd NA 2.508 L/kg 1compartment NA NA Human Human -DTXSID7051474 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7051474 TK.Half.Life NA 2.955 hours 1compartment NA NA Human Human -DTXSID7051474 Css NA 0.04626 mg/L 3compartmentss NA 50% Human Human -DTXSID7051474 Css NA 0.2964 mg/L 3compartmentss NA 95% Human Human -DTXSID7051474 Css NA 0.03163 mg/L PBTK NA 50% Human Human -DTXSID7051474 Css NA 0.1974 mg/L PBTK NA 95% Human Human -DTXSID7051474 Clint NA 316.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7051474 Fup NA 0.0667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7051474 Vd NA 1.883 L/kg 1compartment NA NA Rat Human +DTXSID7049429 TK.Half.Life NA 0.8314 hours 1compartment NA NA Rat Human +DTXSID7049429 Css NA 0.02604 mg/L 3compartmentss NA 50% Rat Human +DTXSID7049429 Css NA 0.1672 mg/L 3compartmentss NA 95% Rat Human +DTXSID7049429 Css NA 0.01676 mg/L PBTK NA 50% Rat Human +DTXSID7049429 Css NA 0.101 mg/L PBTK NA 95% Rat Human +DTXSID7051474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7051474 Fup 0.0503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7051474 Vd NA 2.342 L/kg 1compartment NA NA Human Human +DTXSID7051474 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7051474 TK.Half.Life NA 14.94 hours 1compartment NA NA Human Human +DTXSID7051474 Css NA 0.8128 mg/L 3compartmentss NA 50% Human Human +DTXSID7051474 Css NA 5.511 mg/L 3compartmentss NA 95% Human Human +DTXSID7051474 Css NA 0.5425 mg/L PBTK NA 50% Human Human +DTXSID7051474 Css NA 3.519 mg/L PBTK NA 95% Human Human +DTXSID7051474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7051474 Fup 0.0503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7051474 Vd NA 1.755 L/kg 1compartment NA NA Rat Human DTXSID7051474 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7051474 TK.Half.Life NA 0.8976 hours 1compartment NA NA Rat Human -DTXSID7051474 Css NA 0.02598 mg/L 3compartmentss NA 50% Rat Human -DTXSID7051474 Css NA 0.1447 mg/L 3compartmentss NA 95% Rat Human -DTXSID7051474 Css NA 0.01702 mg/L PBTK NA 50% Rat Human -DTXSID7051474 Css NA 0.09361 mg/L PBTK NA 95% Rat Human -DTXSID7051557 Clint NA 2.034 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7051557 Fup NA 0.7167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7051557 Vd NA 2.038 L/kg 1compartment NA NA Human Human +DTXSID7051474 TK.Half.Life NA 4.151 hours 1compartment NA NA Rat Human +DTXSID7051474 Css NA 0.1049 mg/L 3compartmentss NA 50% Rat Human +DTXSID7051474 Css NA 0.5793 mg/L 3compartmentss NA 95% Rat Human +DTXSID7051474 Css NA 0.06892 mg/L PBTK NA 50% Rat Human +DTXSID7051474 Css NA 0.3679 mg/L PBTK NA 95% Rat Human +DTXSID7051557 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7051557 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7051557 Vd NA 1.622 L/kg 1compartment NA NA Human Human DTXSID7051557 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7051557 TK.Half.Life NA 5.626 hours 1compartment NA NA Human Human -DTXSID7051557 Css NA 0.2388 mg/L 3compartmentss NA 50% Human Human -DTXSID7051557 Css NA 1.81 mg/L 3compartmentss NA 95% Human Human -DTXSID7051557 Css NA 0.2302 mg/L PBTK NA 50% Human Human -DTXSID7051557 Css NA 1.311 mg/L PBTK NA 95% Human Human -DTXSID7051557 Clint NA 2.034 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7051557 Fup NA 0.7167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7051557 Vd NA 1.844 L/kg 1compartment NA NA Rat Human +DTXSID7051557 TK.Half.Life NA 1.607 hours 1compartment NA NA Human Human +DTXSID7051557 Css NA 0.03185 mg/L 3compartmentss NA 50% Human Human +DTXSID7051557 Css NA 0.3146 mg/L 3compartmentss NA 95% Human Human +DTXSID7051557 Css NA 0.0274 mg/L PBTK NA 50% Human Human +DTXSID7051557 Css NA 0.2337 mg/L PBTK NA 95% Human Human +DTXSID7051557 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7051557 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7051557 Vd NA 1.459 L/kg 1compartment NA NA Rat Human DTXSID7051557 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7051557 TK.Half.Life NA 2.377 hours 1compartment NA NA Rat Human -DTXSID7051557 Css NA 0.1023 mg/L 3compartmentss NA 50% Rat Human -DTXSID7051557 Css NA 0.7007 mg/L 3compartmentss NA 95% Rat Human -DTXSID7051557 Css NA 0.09707 mg/L PBTK NA 50% Rat Human -DTXSID7051557 Css NA 0.4505 mg/L PBTK NA 95% Rat Human -DTXSID7051715 Clint NA 10.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7051715 Fup NA 0.924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7051715 Vd NA 2.283 L/kg 1compartment NA NA Human Human -DTXSID7051715 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7051715 TK.Half.Life NA 1.778 hours 1compartment NA NA Human Human -DTXSID7051715 Css NA 0.04016 mg/L 3compartmentss NA 50% Human Human -DTXSID7051715 Css NA 0.2896 mg/L 3compartmentss NA 95% Human Human -DTXSID7051715 Css NA 0.0414 mg/L PBTK NA 50% Human Human -DTXSID7051715 Css NA 0.2528 mg/L PBTK NA 95% Human Human -DTXSID7051715 Clint NA 10.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7051715 Fup NA 0.924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7051715 Vd NA 2.312 L/kg 1compartment NA NA Rat Human +DTXSID7051557 TK.Half.Life NA 0.7142 hours 1compartment NA NA Rat Human +DTXSID7051557 Css NA 0.001145 mg/L 3compartmentss NA 50% Rat Human +DTXSID7051557 Css NA 0.01136 mg/L 3compartmentss NA 95% Rat Human +DTXSID7051557 Css NA 0.0009792 mg/L PBTK NA 50% Rat Human +DTXSID7051557 Css NA 0.008449 mg/L PBTK NA 95% Rat Human +DTXSID7051715 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7051715 Fup 0.867 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7051715 Vd NA 2.178 L/kg 1compartment NA NA Human Human +DTXSID7051715 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7051715 TK.Half.Life NA 16.41 hours 1compartment NA NA Human Human +DTXSID7051715 Css NA 0.646 mg/L 3compartmentss NA 50% Human Human +DTXSID7051715 Css NA 4.299 mg/L 3compartmentss NA 95% Human Human +DTXSID7051715 Css NA 0.6744 mg/L PBTK NA 50% Human Human +DTXSID7051715 Css NA 3.07 mg/L PBTK NA 95% Human Human +DTXSID7051715 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7051715 Fup 0.867 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7051715 Vd NA 2.204 L/kg 1compartment NA NA Rat Human DTXSID7051715 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7051715 TK.Half.Life NA 0.9372 hours 1compartment NA NA Rat Human -DTXSID7051715 Css NA 0.01922 mg/L 3compartmentss NA 50% Rat Human -DTXSID7051715 Css NA 0.1052 mg/L 3compartmentss NA 95% Rat Human -DTXSID7051715 Css NA 0.02024 mg/L PBTK NA 50% Rat Human -DTXSID7051715 Css NA 0.08927 mg/L PBTK NA 95% Rat Human -DTXSID7052288 Clint NA 0.3029 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052288 Fup NA 0.6461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052288 Vd NA 2.306 L/kg 1compartment NA NA Human Human -DTXSID7052288 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7052288 TK.Half.Life NA 28.09 hours 1compartment NA NA Human Human -DTXSID7052288 Css NA 1.201 mg/L 3compartmentss NA 50% Human Human -DTXSID7052288 Css NA 6.273 mg/L 3compartmentss NA 95% Human Human -DTXSID7052288 Css NA 1.041 mg/L PBTK NA 50% Human Human -DTXSID7052288 Css NA 4.235 mg/L PBTK NA 95% Human Human -DTXSID7052288 Clint NA 0.3029 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052288 Fup NA 0.6461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052288 Vd NA 1.857 L/kg 1compartment NA NA Rat Human +DTXSID7051715 TK.Half.Life NA 5.617 hours 1compartment NA NA Rat Human +DTXSID7051715 Css NA 0.012 mg/L 3compartmentss NA 50% Rat Human +DTXSID7051715 Css NA 0.09912 mg/L 3compartmentss NA 95% Rat Human +DTXSID7051715 Css NA 0.0121 mg/L PBTK NA 50% Rat Human +DTXSID7051715 Css NA 0.07238 mg/L PBTK NA 95% Rat Human +DTXSID7051890 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7051890 Fup 0.0443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7051890 Vd NA 2.307 L/kg 1compartment NA NA Human Human +DTXSID7051890 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7051890 TK.Half.Life NA 15.69 hours 1compartment NA NA Human Human +DTXSID7051890 Css NA 0.8886 mg/L 3compartmentss NA 50% Human Human +DTXSID7051890 Css NA 6.453 mg/L 3compartmentss NA 95% Human Human +DTXSID7051890 Css NA 0.5926 mg/L PBTK NA 50% Human Human +DTXSID7051890 Css NA 4.135 mg/L PBTK NA 95% Human Human +DTXSID7051890 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7051890 Fup 0.0443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7051890 Vd NA 1.727 L/kg 1compartment NA NA Rat Human +DTXSID7051890 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7051890 TK.Half.Life NA 4.435 hours 1compartment NA NA Rat Human +DTXSID7051890 Css NA 0.1143 mg/L 3compartmentss NA 50% Rat Human +DTXSID7051890 Css NA 0.6793 mg/L 3compartmentss NA 95% Rat Human +DTXSID7051890 Css NA 0.07453 mg/L PBTK NA 50% Rat Human +DTXSID7051890 Css NA 0.4286 mg/L PBTK NA 95% Rat Human +DTXSID7052286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052286 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052286 Vd NA 0.6815 L/kg 1compartment NA NA Human Human +DTXSID7052286 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7052286 TK.Half.Life NA 1.038 hours 1compartment NA NA Human Human +DTXSID7052286 Css NA 0.0917 mg/L 3compartmentss NA 50% Human Human +DTXSID7052286 Css NA 0.6852 mg/L 3compartmentss NA 95% Human Human +DTXSID7052286 Css NA 0.06383 mg/L PBTK NA 50% Human Human +DTXSID7052286 Css NA 0.4376 mg/L PBTK NA 95% Human Human +DTXSID7052286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052286 Fup 0.229 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052286 Vd NA 0.6108 L/kg 1compartment NA NA Rat Human +DTXSID7052286 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7052286 TK.Half.Life NA 0.503 hours 1compartment NA NA Rat Human +DTXSID7052286 Css NA 0.0117 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052286 Css NA 0.06264 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052286 Css NA 0.008047 mg/L PBTK NA 50% Rat Human +DTXSID7052286 Css NA 0.04027 mg/L PBTK NA 95% Rat Human +DTXSID7052288 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052288 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052288 Vd NA 1.492 L/kg 1compartment NA NA Human Human +DTXSID7052288 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7052288 TK.Half.Life NA 2.461 hours 1compartment NA NA Human Human +DTXSID7052288 Css NA 0.1086 mg/L 3compartmentss NA 50% Human Human +DTXSID7052288 Css NA 0.7423 mg/L 3compartmentss NA 95% Human Human +DTXSID7052288 Css NA 0.07866 mg/L PBTK NA 50% Human Human +DTXSID7052288 Css NA 0.4979 mg/L PBTK NA 95% Human Human +DTXSID7052288 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052288 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052288 Vd NA 1.185 L/kg 1compartment NA NA Rat Human DTXSID7052288 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7052288 TK.Half.Life NA 6.059 hours 1compartment NA NA Rat Human -DTXSID7052288 Css NA 0.3946 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052288 Css NA 1.813 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052288 Css NA 0.3325 mg/L PBTK NA 50% Rat Human -DTXSID7052288 Css NA 1.135 mg/L PBTK NA 95% Rat Human -DTXSID7052319 Clint NA 9.515 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052319 Fup NA 0.2792 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052319 Vd NA 1.382 L/kg 1compartment NA NA Human Human +DTXSID7052288 TK.Half.Life NA 0.9685 hours 1compartment NA NA Rat Human +DTXSID7052288 Css NA 0.01364 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052288 Css NA 0.07152 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052288 Css NA 0.00987 mg/L PBTK NA 50% Rat Human +DTXSID7052288 Css NA 0.0483 mg/L PBTK NA 95% Rat Human +DTXSID7052319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052319 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052319 Vd NA 0.9351 L/kg 1compartment NA NA Human Human DTXSID7052319 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7052319 TK.Half.Life NA 3.099 hours 1compartment NA NA Human Human -DTXSID7052319 Css NA 0.1864 mg/L 3compartmentss NA 50% Human Human -DTXSID7052319 Css NA 1.218 mg/L 3compartmentss NA 95% Human Human -DTXSID7052319 Css NA 0.139 mg/L PBTK NA 50% Human Human -DTXSID7052319 Css NA 0.8231 mg/L PBTK NA 95% Human Human -DTXSID7052319 Clint NA 9.515 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052319 Fup NA 0.2792 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052319 Vd NA 1.124 L/kg 1compartment NA NA Rat Human +DTXSID7052319 TK.Half.Life NA 2.024 hours 1compartment NA NA Human Human +DTXSID7052319 Css NA 0.201 mg/L 3compartmentss NA 50% Human Human +DTXSID7052319 Css NA 1.619 mg/L 3compartmentss NA 95% Human Human +DTXSID7052319 Css NA 0.1325 mg/L PBTK NA 50% Human Human +DTXSID7052319 Css NA 1 mg/L PBTK NA 95% Human Human +DTXSID7052319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052319 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052319 Vd NA 0.7547 L/kg 1compartment NA NA Rat Human DTXSID7052319 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7052319 TK.Half.Life NA 1.297 hours 1compartment NA NA Rat Human -DTXSID7052319 Css NA 0.09752 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052319 Css NA 0.4662 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052319 Css NA 0.07042 mg/L PBTK NA 50% Rat Human -DTXSID7052319 Css NA 0.3007 mg/L PBTK NA 95% Rat Human -DTXSID7052446 Clint NA 5.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052446 Fup NA 0.3572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052446 Vd NA 1.173 L/kg 1compartment NA NA Human Human +DTXSID7052319 TK.Half.Life NA 0.9015 hours 1compartment NA NA Rat Human +DTXSID7052319 Css NA 0.02665 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052319 Css NA 0.1569 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052319 Css NA 0.01718 mg/L PBTK NA 50% Rat Human +DTXSID7052319 Css NA 0.09588 mg/L PBTK NA 95% Rat Human +DTXSID7052446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052446 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052446 Vd NA 1.117 L/kg 1compartment NA NA Human Human DTXSID7052446 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7052446 TK.Half.Life NA 3.011 hours 1compartment NA NA Human Human -DTXSID7052446 Css NA 0.2242 mg/L 3compartmentss NA 50% Human Human -DTXSID7052446 Css NA 1.433 mg/L 3compartmentss NA 95% Human Human -DTXSID7052446 Css NA 0.173 mg/L PBTK NA 50% Human Human -DTXSID7052446 Css NA 0.9705 mg/L PBTK NA 95% Human Human -DTXSID7052446 Clint NA 5.323 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052446 Fup NA 0.3572 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052446 Vd NA 0.9978 L/kg 1compartment NA NA Rat Human +DTXSID7052446 TK.Half.Life NA 1.401 hours 1compartment NA NA Human Human +DTXSID7052446 Css NA 0.06334 mg/L 3compartmentss NA 50% Human Human +DTXSID7052446 Css NA 0.4542 mg/L 3compartmentss NA 95% Human Human +DTXSID7052446 Css NA 0.04796 mg/L PBTK NA 50% Human Human +DTXSID7052446 Css NA 0.3156 mg/L PBTK NA 95% Human Human +DTXSID7052446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052446 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052446 Vd NA 0.95 L/kg 1compartment NA NA Rat Human DTXSID7052446 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7052446 TK.Half.Life NA 1.361 hours 1compartment NA NA Rat Human -DTXSID7052446 Css NA 0.1124 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052446 Css NA 0.5136 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052446 Css NA 0.08356 mg/L PBTK NA 50% Rat Human -DTXSID7052446 Css NA 0.3301 mg/L PBTK NA 95% Rat Human -DTXSID7052529 Clint NA 16.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052529 Fup NA 0.3492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052529 Vd NA 1.733 L/kg 1compartment NA NA Human Human +DTXSID7052446 TK.Half.Life NA 0.608 hours 1compartment NA NA Rat Human +DTXSID7052446 Css NA 0.007862 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052446 Css NA 0.04464 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052446 Css NA 0.005921 mg/L PBTK NA 50% Rat Human +DTXSID7052446 Css NA 0.03049 mg/L PBTK NA 95% Rat Human +DTXSID7052529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052529 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052529 Vd NA 1.138 L/kg 1compartment NA NA Human Human DTXSID7052529 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7052529 TK.Half.Life NA 2.63 hours 1compartment NA NA Human Human -DTXSID7052529 Css NA 0.09796 mg/L 3compartmentss NA 50% Human Human -DTXSID7052529 Css NA 0.6926 mg/L 3compartmentss NA 95% Human Human -DTXSID7052529 Css NA 0.07629 mg/L PBTK NA 50% Human Human -DTXSID7052529 Css NA 0.4809 mg/L PBTK NA 95% Human Human -DTXSID7052529 Clint NA 16.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052529 Fup NA 0.3492 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052529 Vd NA 1.39 L/kg 1compartment NA NA Rat Human +DTXSID7052529 TK.Half.Life NA 2.48 hours 1compartment NA NA Human Human +DTXSID7052529 Css NA 0.2034 mg/L 3compartmentss NA 50% Human Human +DTXSID7052529 Css NA 1.582 mg/L 3compartmentss NA 95% Human Human +DTXSID7052529 Css NA 0.1362 mg/L PBTK NA 50% Human Human +DTXSID7052529 Css NA 0.9959 mg/L PBTK NA 95% Human Human +DTXSID7052529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052529 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052529 Vd NA 0.8998 L/kg 1compartment NA NA Rat Human DTXSID7052529 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7052529 TK.Half.Life NA 0.9982 hours 1compartment NA NA Rat Human -DTXSID7052529 Css NA 0.05284 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052529 Css NA 0.272 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052529 Css NA 0.03969 mg/L PBTK NA 50% Rat Human -DTXSID7052529 Css NA 0.1869 mg/L PBTK NA 95% Rat Human -DTXSID7052571 Clint NA 7.489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052571 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052571 Vd NA 2.053 L/kg 1compartment NA NA Human Human -DTXSID7052571 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7052571 TK.Half.Life NA 23.53 hours 1compartment NA NA Human Human -DTXSID7052571 Css NA 1.634 mg/L 3compartmentss NA 50% Human Human -DTXSID7052571 Css NA 9.829 mg/L 3compartmentss NA 95% Human Human -DTXSID7052571 Css NA 1.088 mg/L PBTK NA 50% Human Human -DTXSID7052571 Css NA 6.234 mg/L PBTK NA 95% Human Human -DTXSID7052571 Clint NA 7.489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052571 Fup NA 0.0643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052571 Vd NA 1.543 L/kg 1compartment NA NA Rat Human -DTXSID7052571 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7052571 TK.Half.Life NA 7.291 hours 1compartment NA NA Rat Human -DTXSID7052571 Css NA 0.8753 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052571 Css NA 3.889 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052571 Css NA 0.5512 mg/L PBTK NA 50% Rat Human -DTXSID7052571 Css NA 2.326 mg/L PBTK NA 95% Rat Human -DTXSID7052573 Clint NA 29.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052573 Fup NA 0.1758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052573 Vd NA 2.125 L/kg 1compartment NA NA Human Human -DTXSID7052573 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7052573 TK.Half.Life NA 4.104 hours 1compartment NA NA Human Human -DTXSID7052573 Css NA 0.1464 mg/L 3compartmentss NA 50% Human Human -DTXSID7052573 Css NA 0.947 mg/L 3compartmentss NA 95% Human Human -DTXSID7052573 Css NA 0.1049 mg/L PBTK NA 50% Human Human -DTXSID7052573 Css NA 0.6514 mg/L PBTK NA 95% Human Human -DTXSID7052573 Clint NA 29.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052573 Fup NA 0.1758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052573 Vd NA 1.628 L/kg 1compartment NA NA Rat Human +DTXSID7052529 TK.Half.Life NA 1.05 hours 1compartment NA NA Rat Human +DTXSID7052529 Css NA 0.02626 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052529 Css NA 0.1598 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052529 Css NA 0.01713 mg/L PBTK NA 50% Rat Human +DTXSID7052529 Css NA 0.09849 mg/L PBTK NA 95% Rat Human +DTXSID7052571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052571 Fup 0.0393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052571 Vd NA 2.424 L/kg 1compartment NA NA Human Human +DTXSID7052571 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7052571 TK.Half.Life NA 19.14 hours 1compartment NA NA Human Human +DTXSID7052571 Css NA 1.043 mg/L 3compartmentss NA 50% Human Human +DTXSID7052571 Css NA 7.596 mg/L 3compartmentss NA 95% Human Human +DTXSID7052571 Css NA 0.6952 mg/L PBTK NA 50% Human Human +DTXSID7052571 Css NA 4.777 mg/L PBTK NA 95% Human Human +DTXSID7052571 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052571 Fup 0.0393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052571 Vd NA 1.813 L/kg 1compartment NA NA Rat Human +DTXSID7052571 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7052571 TK.Half.Life NA 5.045 hours 1compartment NA NA Rat Human +DTXSID7052571 Css NA 0.1362 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052571 Css NA 0.8179 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052571 Css NA 0.08882 mg/L PBTK NA 50% Rat Human +DTXSID7052571 Css NA 0.5073 mg/L PBTK NA 95% Rat Human +DTXSID7052573 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052573 Fup 0.0388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052573 Vd NA 1.192 L/kg 1compartment NA NA Human Human +DTXSID7052573 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID7052573 TK.Half.Life NA 18.7 hours 1compartment NA NA Human Human +DTXSID7052573 Css NA 2.574 mg/L 3compartmentss NA 50% Human Human +DTXSID7052573 Css NA 19.04 mg/L 3compartmentss NA 95% Human Human +DTXSID7052573 Css NA 1.613 mg/L PBTK NA 50% Human Human +DTXSID7052573 Css NA 11.45 mg/L PBTK NA 95% Human Human +DTXSID7052573 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052573 Fup 0.0388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052573 Vd NA 0.8969 L/kg 1compartment NA NA Rat Human DTXSID7052573 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7052573 TK.Half.Life NA 1.341 hours 1compartment NA NA Rat Human -DTXSID7052573 Css NA 0.08015 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052573 Css NA 0.4029 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052573 Css NA 0.05499 mg/L PBTK NA 50% Rat Human -DTXSID7052573 Css NA 0.2623 mg/L PBTK NA 95% Rat Human +DTXSID7052573 TK.Half.Life NA 7.673 hours 1compartment NA NA Rat Human +DTXSID7052573 Css NA 0.3204 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052573 Css NA 1.916 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052573 Css NA 0.1938 mg/L PBTK NA 50% Rat Human +DTXSID7052573 Css NA 1.102 mg/L PBTK NA 95% Rat Human +DTXSID7052575 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052575 Fup 0.0461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052575 Vd NA 1.799 L/kg 1compartment NA NA Human Human +DTXSID7052575 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7052575 TK.Half.Life NA 9.666 hours 1compartment NA NA Human Human +DTXSID7052575 Css NA 0.7226 mg/L 3compartmentss NA 50% Human Human +DTXSID7052575 Css NA 5.166 mg/L 3compartmentss NA 95% Human Human +DTXSID7052575 Css NA 0.4672 mg/L PBTK NA 50% Human Human +DTXSID7052575 Css NA 3.213 mg/L PBTK NA 95% Human Human +DTXSID7052575 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052575 Fup 0.0461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052575 Vd NA 1.347 L/kg 1compartment NA NA Rat Human +DTXSID7052575 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7052575 TK.Half.Life NA 3.394 hours 1compartment NA NA Rat Human +DTXSID7052575 Css NA 0.09291 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052575 Css NA 0.5344 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052575 Css NA 0.0588 mg/L PBTK NA 50% Rat Human +DTXSID7052575 Css NA 0.3223 mg/L PBTK NA 95% Rat Human DTXSID7052577 Clint NA 0.2453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID7052577 Fup NA 0.3002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052577 Vd NA 0.8997 L/kg 1compartment NA NA Human Human +DTXSID7052577 Vd NA 0.8236 L/kg 1compartment NA NA Human Human DTXSID7052577 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7052577 TK.Half.Life NA 14.56 hours 1compartment NA NA Human Human -DTXSID7052577 Css NA 1.744 mg/L 3compartmentss NA 50% Human Human -DTXSID7052577 Css NA 7.199 mg/L 3compartmentss NA 95% Human Human -DTXSID7052577 Css NA 1.297 mg/L PBTK NA 50% Human Human -DTXSID7052577 Css NA 4.61 mg/L PBTK NA 95% Human Human +DTXSID7052577 TK.Half.Life NA 13.15 hours 1compartment NA NA Human Human +DTXSID7052577 Css NA 1.703 mg/L 3compartmentss NA 50% Human Human +DTXSID7052577 Css NA 7.102 mg/L 3compartmentss NA 95% Human Human +DTXSID7052577 Css NA 1.246 mg/L PBTK NA 50% Human Human +DTXSID7052577 Css NA 4.5 mg/L PBTK NA 95% Human Human DTXSID7052577 Clint NA 0.2453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID7052577 Fup NA 0.3002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052577 Vd NA 0.7879 L/kg 1compartment NA NA Rat Human +DTXSID7052577 Vd NA 0.7335 L/kg 1compartment NA NA Rat Human DTXSID7052577 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7052577 TK.Half.Life NA 4.885 hours 1compartment NA NA Rat Human -DTXSID7052577 Css NA 0.5794 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052577 Css NA 1.973 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052577 Css NA 0.4082 mg/L PBTK NA 50% Rat Human -DTXSID7052577 Css NA 1.182 mg/L PBTK NA 95% Rat Human -DTXSID7052602 Clint NA 3.831 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052602 Fup NA 0.1129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052602 Vd NA 2.109 L/kg 1compartment NA NA Human Human -DTXSID7052602 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID7052602 TK.Half.Life NA 27.56 hours 1compartment NA NA Human Human -DTXSID7052602 Css NA 1.767 mg/L 3compartmentss NA 50% Human Human -DTXSID7052602 Css NA 9.525 mg/L 3compartmentss NA 95% Human Human -DTXSID7052602 Css NA 1.213 mg/L PBTK NA 50% Human Human -DTXSID7052602 Css NA 6.189 mg/L PBTK NA 95% Human Human -DTXSID7052602 Clint NA 3.831 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052602 Fup NA 0.1129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052602 Vd NA 1.599 L/kg 1compartment NA NA Rat Human -DTXSID7052602 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7052602 TK.Half.Life NA 8.079 hours 1compartment NA NA Rat Human -DTXSID7052602 Css NA 0.8969 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052602 Css NA 3.529 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052602 Css NA 0.5844 mg/L PBTK NA 50% Rat Human -DTXSID7052602 Css NA 2.124 mg/L PBTK NA 95% Rat Human -DTXSID7052654 Clint NA 1.358 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052654 Fup NA 0.8737 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052654 Vd NA 1.653 L/kg 1compartment NA NA Human Human -DTXSID7052654 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7052654 TK.Half.Life NA 4.892 hours 1compartment NA NA Human Human -DTXSID7052654 Css NA 0.2834 mg/L 3compartmentss NA 50% Human Human -DTXSID7052654 Css NA 1.913 mg/L 3compartmentss NA 95% Human Human -DTXSID7052654 Css NA 0.2612 mg/L PBTK NA 50% Human Human -DTXSID7052654 Css NA 1.327 mg/L PBTK NA 95% Human Human -DTXSID7052654 Clint NA 1.358 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052654 Fup NA 0.8737 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052654 Vd NA 1.442 L/kg 1compartment NA NA Rat Human -DTXSID7052654 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7052654 TK.Half.Life NA 1.889 hours 1compartment NA NA Rat Human -DTXSID7052654 Css NA 0.1133 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052654 Css NA 0.6597 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052654 Css NA 0.1034 mg/L PBTK NA 50% Rat Human -DTXSID7052654 Css NA 0.4289 mg/L PBTK NA 95% Rat Human -DTXSID7052860 Clint NA 67.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052860 Fup NA 0.0976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052860 Vd NA 0.6254 L/kg 1compartment NA NA Human Human +DTXSID7052577 TK.Half.Life NA 4.536 hours 1compartment NA NA Rat Human +DTXSID7052577 Css NA 0.1294 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052577 Css NA 0.4505 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052577 Css NA 0.09415 mg/L PBTK NA 50% Rat Human +DTXSID7052577 Css NA 0.2766 mg/L PBTK NA 95% Rat Human +DTXSID7052602 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052602 Fup 0.0565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052602 Vd NA 1.632 L/kg 1compartment NA NA Human Human +DTXSID7052602 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7052602 TK.Half.Life NA 7.229 hours 1compartment NA NA Human Human +DTXSID7052602 Css NA 0.5706 mg/L 3compartmentss NA 50% Human Human +DTXSID7052602 Css NA 4.297 mg/L 3compartmentss NA 95% Human Human +DTXSID7052602 Css NA 0.3684 mg/L PBTK NA 50% Human Human +DTXSID7052602 Css NA 2.664 mg/L PBTK NA 95% Human Human +DTXSID7052602 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052602 Fup 0.0565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052602 Vd NA 1.228 L/kg 1compartment NA NA Rat Human +DTXSID7052602 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7052602 TK.Half.Life NA 2.685 hours 1compartment NA NA Rat Human +DTXSID7052602 Css NA 0.07376 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052602 Css NA 0.4357 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052602 Css NA 0.04652 mg/L PBTK NA 50% Rat Human +DTXSID7052602 Css NA 0.2655 mg/L PBTK NA 95% Rat Human +DTXSID7052606 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052606 Fup 0.0274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052606 Vd NA 10.01 L/kg 1compartment NA NA Human Human +DTXSID7052606 Days.Css NA 55 Days PBTK NA NA Human Human +DTXSID7052606 TK.Half.Life NA 270.5 hours 1compartment NA NA Human Human +DTXSID7052606 Css NA 1.671 mg/L 3compartmentss NA 50% Human Human +DTXSID7052606 Css NA 11.84 mg/L 3compartmentss NA 95% Human Human +DTXSID7052606 Css NA 1.978 mg/L PBTK NA 50% Human Human +DTXSID7052606 Css NA 12.48 mg/L PBTK NA 95% Human Human +DTXSID7052606 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052606 Fup 0.0274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052606 Vd NA 7.879 L/kg 1compartment NA NA Rat Human +DTXSID7052606 Days.Css NA 33 Days PBTK NA NA Rat Human +DTXSID7052606 TK.Half.Life NA 37.86 hours 1compartment NA NA Rat Human +DTXSID7052606 Css NA 0.07948 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052606 Css NA 0.5813 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052606 Css NA 0.0976 mg/L PBTK NA 50% Rat Human +DTXSID7052606 Css NA 0.6176 mg/L PBTK NA 95% Rat Human +DTXSID7052860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052860 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7052860 Vd NA 0.801 L/kg 1compartment NA NA Human Human DTXSID7052860 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7052860 TK.Half.Life NA 0.9061 hours 1compartment NA NA Human Human -DTXSID7052860 Css NA 0.09718 mg/L 3compartmentss NA 50% Human Human -DTXSID7052860 Css NA 0.8161 mg/L 3compartmentss NA 95% Human Human -DTXSID7052860 Css NA 0.0613 mg/L PBTK NA 50% Human Human -DTXSID7052860 Css NA 0.4995 mg/L PBTK NA 95% Human Human -DTXSID7052860 Clint NA 67.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052860 Fup NA 0.0976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052860 Vd NA 0.5219 L/kg 1compartment NA NA Rat Human +DTXSID7052860 TK.Half.Life NA 1.53 hours 1compartment NA NA Human Human +DTXSID7052860 Css NA 0.1556 mg/L 3compartmentss NA 50% Human Human +DTXSID7052860 Css NA 1.228 mg/L 3compartmentss NA 95% Human Human +DTXSID7052860 Css NA 0.1037 mg/L PBTK NA 50% Human Human +DTXSID7052860 Css NA 0.7816 mg/L PBTK NA 95% Human Human +DTXSID7052860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052860 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7052860 Vd NA 0.6701 L/kg 1compartment NA NA Rat Human DTXSID7052860 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7052860 TK.Half.Life NA 0.3988 hours 1compartment NA NA Rat Human -DTXSID7052860 Css NA 0.05595 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052860 Css NA 0.3839 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052860 Css NA 0.03318 mg/L PBTK NA 50% Rat Human -DTXSID7052860 Css NA 0.2172 mg/L PBTK NA 95% Rat Human -DTXSID7052866 Clint NA 60 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052866 Fup NA 0.0084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7052866 Vd NA 14.97 L/kg 1compartment NA NA Human Human -DTXSID7052866 Days.Css NA 29 Days PBTK NA NA Human Human -DTXSID7052866 TK.Half.Life NA 165.4 hours 1compartment NA NA Human Human -DTXSID7052866 Css NA 0.5499 mg/L 3compartmentss NA 50% Human Human -DTXSID7052866 Css NA 3.175 mg/L 3compartmentss NA 95% Human Human -DTXSID7052866 Css NA 0.8938 mg/L PBTK NA 50% Human Human -DTXSID7052866 Css NA 4.867 mg/L PBTK NA 95% Human Human -DTXSID7052866 Clint NA 60 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052866 Fup NA 0.0084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7052866 Vd NA 12 L/kg 1compartment NA NA Rat Human -DTXSID7052866 Days.Css NA 18 Days PBTK NA NA Rat Human -DTXSID7052866 TK.Half.Life NA 24.38 hours 1compartment NA NA Rat Human -DTXSID7052866 Css NA 0.2919 mg/L 3compartmentss NA 50% Rat Human -DTXSID7052866 Css NA 1.266 mg/L 3compartmentss NA 95% Rat Human -DTXSID7052866 Css NA 0.483 mg/L PBTK NA 50% Rat Human -DTXSID7052866 Css NA 2.187 mg/L PBTK NA 95% Rat Human -DTXSID7057602 Clint NA 16.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057602 Fup NA 0.6651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057602 Vd NA 1.179 L/kg 1compartment NA NA Human Human +DTXSID7052860 TK.Half.Life NA 0.7078 hours 1compartment NA NA Rat Human +DTXSID7052860 Css NA 0.02027 mg/L 3compartmentss NA 50% Rat Human +DTXSID7052860 Css NA 0.1168 mg/L 3compartmentss NA 95% Rat Human +DTXSID7052860 Css NA 0.01324 mg/L PBTK NA 50% Rat Human +DTXSID7052860 Css NA 0.0718 mg/L PBTK NA 95% Rat Human +DTXSID7057573 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057573 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057573 Vd NA 0.9002 L/kg 1compartment NA NA Human Human +DTXSID7057573 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7057573 TK.Half.Life NA 4.469 hours 1compartment NA NA Human Human +DTXSID7057573 Css NA 0.6317 mg/L 3compartmentss NA 50% Human Human +DTXSID7057573 Css NA 4.178 mg/L 3compartmentss NA 95% Human Human +DTXSID7057573 Css NA 0.4142 mg/L PBTK NA 50% Human Human +DTXSID7057573 Css NA 2.569 mg/L PBTK NA 95% Human Human +DTXSID7057573 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057573 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057573 Vd NA 0.7184 L/kg 1compartment NA NA Rat Human +DTXSID7057573 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7057573 TK.Half.Life NA 2.013 hours 1compartment NA NA Rat Human +DTXSID7057573 Css NA 0.07574 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057573 Css NA 0.3841 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057573 Css NA 0.04876 mg/L PBTK NA 50% Rat Human +DTXSID7057573 Css NA 0.2277 mg/L PBTK NA 95% Rat Human +DTXSID7057602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057602 Fup 0.518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057602 Vd NA 1.191 L/kg 1compartment NA NA Human Human DTXSID7057602 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057602 TK.Half.Life NA 1.102 hours 1compartment NA NA Human Human -DTXSID7057602 Css NA 0.04401 mg/L 3compartmentss NA 50% Human Human -DTXSID7057602 Css NA 0.4236 mg/L 3compartmentss NA 95% Human Human -DTXSID7057602 Css NA 0.03706 mg/L PBTK NA 50% Human Human -DTXSID7057602 Css NA 0.2977 mg/L PBTK NA 95% Human Human -DTXSID7057602 Clint NA 16.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057602 Fup NA 0.6651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057602 Vd NA 1.061 L/kg 1compartment NA NA Rat Human +DTXSID7057602 TK.Half.Life NA 2.059 hours 1compartment NA NA Human Human +DTXSID7057602 Css NA 0.1114 mg/L 3compartmentss NA 50% Human Human +DTXSID7057602 Css NA 0.8802 mg/L 3compartmentss NA 95% Human Human +DTXSID7057602 Css NA 0.09042 mg/L PBTK NA 50% Human Human +DTXSID7057602 Css NA 0.6116 mg/L PBTK NA 95% Human Human +DTXSID7057602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057602 Fup 0.518 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057602 Vd NA 1.038 L/kg 1compartment NA NA Rat Human DTXSID7057602 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057602 TK.Half.Life NA 0.4906 hours 1compartment NA NA Rat Human -DTXSID7057602 Css NA 0.02204 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057602 Css NA 0.1924 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057602 Css NA 0.01822 mg/L PBTK NA 50% Rat Human -DTXSID7057602 Css NA 0.1259 mg/L PBTK NA 95% Rat Human -DTXSID7057604 Clint NA 2.579 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057604 Fup NA 0.2266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057604 Vd NA 2.054 L/kg 1compartment NA NA Human Human +DTXSID7057602 TK.Half.Life NA 0.9369 hours 1compartment NA NA Rat Human +DTXSID7057602 Css NA 0.00476 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057602 Css NA 0.04406 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057602 Css NA 0.00393 mg/L PBTK NA 50% Rat Human +DTXSID7057602 Css NA 0.02991 mg/L PBTK NA 95% Rat Human +DTXSID7057604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057604 Fup 0.199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057604 Vd NA 0.5282 L/kg 1compartment NA NA Human Human DTXSID7057604 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057604 TK.Half.Life NA 11.75 hours 1compartment NA NA Human Human -DTXSID7057604 Css NA 0.5191 mg/L 3compartmentss NA 50% Human Human -DTXSID7057604 Css NA 2.878 mg/L 3compartmentss NA 95% Human Human -DTXSID7057604 Css NA 0.4554 mg/L PBTK NA 50% Human Human -DTXSID7057604 Css NA 2.128 mg/L PBTK NA 95% Human Human -DTXSID7057604 Clint NA 2.579 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057604 Fup NA 0.2266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057604 Vd NA 2.027 L/kg 1compartment NA NA Rat Human +DTXSID7057604 TK.Half.Life NA 0.8635 hours 1compartment NA NA Human Human +DTXSID7057604 Css NA 0.1048 mg/L 3compartmentss NA 50% Human Human +DTXSID7057604 Css NA 0.8147 mg/L 3compartmentss NA 95% Human Human +DTXSID7057604 Css NA 0.07103 mg/L PBTK NA 50% Human Human +DTXSID7057604 Css NA 0.5115 mg/L PBTK NA 95% Human Human +DTXSID7057604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057604 Fup 0.199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057604 Vd NA 0.5439 L/kg 1compartment NA NA Rat Human DTXSID7057604 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057604 TK.Half.Life NA 6.418 hours 1compartment NA NA Rat Human -DTXSID7057604 Css NA 0.2399 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057604 Css NA 1.009 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057604 Css NA 0.2066 mg/L PBTK NA 50% Rat Human -DTXSID7057604 Css NA 0.6787 mg/L PBTK NA 95% Rat Human -DTXSID7057606 Clint NA 0.1341 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057606 Fup NA 0.7882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057606 Vd NA 1.512 L/kg 1compartment NA NA Human Human -DTXSID7057606 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057606 TK.Half.Life NA 10.18 hours 1compartment NA NA Human Human -DTXSID7057606 Css NA 0.6968 mg/L 3compartmentss NA 50% Human Human -DTXSID7057606 Css NA 4.579 mg/L 3compartmentss NA 95% Human Human -DTXSID7057606 Css NA 0.6614 mg/L PBTK NA 50% Human Human -DTXSID7057606 Css NA 3.093 mg/L PBTK NA 95% Human Human -DTXSID7057606 Clint NA 0.1341 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057606 Fup NA 0.7882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057606 Vd NA 1.5 L/kg 1compartment NA NA Rat Human +DTXSID7057604 TK.Half.Life NA 0.4926 hours 1compartment NA NA Rat Human +DTXSID7057604 Css NA 0.01352 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057604 Css NA 0.07214 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057604 Css NA 0.008968 mg/L PBTK NA 50% Rat Human +DTXSID7057604 Css NA 0.04595 mg/L PBTK NA 95% Rat Human +DTXSID7057606 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057606 Fup 0.433 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057606 Vd NA 1.019 L/kg 1compartment NA NA Human Human +DTXSID7057606 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7057606 TK.Half.Life NA 15.22 hours 1compartment NA NA Human Human +DTXSID7057606 Css NA 1.286 mg/L 3compartmentss NA 50% Human Human +DTXSID7057606 Css NA 6.174 mg/L 3compartmentss NA 95% Human Human +DTXSID7057606 Css NA 1.047 mg/L PBTK NA 50% Human Human +DTXSID7057606 Css NA 4.151 mg/L PBTK NA 95% Human Human +DTXSID7057606 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057606 Fup 0.433 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057606 Vd NA 1.006 L/kg 1compartment NA NA Rat Human DTXSID7057606 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057606 TK.Half.Life NA 3.79 hours 1compartment NA NA Rat Human -DTXSID7057606 Css NA 0.1972 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057606 Css NA 1.402 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057606 Css NA 0.1837 mg/L PBTK NA 50% Rat Human -DTXSID7057606 Css NA 0.8717 mg/L PBTK NA 95% Rat Human -DTXSID7057608 Clint NA 5.654 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057608 Fup NA 0.3319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057608 Vd NA 0.9558 L/kg 1compartment NA NA Human Human +DTXSID7057606 TK.Half.Life NA 5.123 hours 1compartment NA NA Rat Human +DTXSID7057606 Css NA 0.02355 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057606 Css NA 0.1739 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057606 Css NA 0.01868 mg/L PBTK NA 50% Rat Human +DTXSID7057606 Css NA 0.116 mg/L PBTK NA 95% Rat Human +DTXSID7057608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057608 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057608 Vd NA 0.7496 L/kg 1compartment NA NA Human Human DTXSID7057608 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057608 TK.Half.Life NA 2.443 hours 1compartment NA NA Human Human -DTXSID7057608 Css NA 0.2347 mg/L 3compartmentss NA 50% Human Human -DTXSID7057608 Css NA 1.399 mg/L 3compartmentss NA 95% Human Human -DTXSID7057608 Css NA 0.1748 mg/L PBTK NA 50% Human Human -DTXSID7057608 Css NA 0.929 mg/L PBTK NA 95% Human Human -DTXSID7057608 Clint NA 5.654 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057608 Fup NA 0.3319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057608 Vd NA 0.8309 L/kg 1compartment NA NA Rat Human +DTXSID7057608 TK.Half.Life NA 2.498 hours 1compartment NA NA Human Human +DTXSID7057608 Css NA 0.3254 mg/L 3compartmentss NA 50% Human Human +DTXSID7057608 Css NA 1.858 mg/L 3compartmentss NA 95% Human Human +DTXSID7057608 Css NA 0.2244 mg/L PBTK NA 50% Human Human +DTXSID7057608 Css NA 1.206 mg/L PBTK NA 95% Human Human +DTXSID7057608 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057608 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057608 Vd NA 0.6506 L/kg 1compartment NA NA Rat Human DTXSID7057608 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057608 TK.Half.Life NA 1.163 hours 1compartment NA NA Rat Human -DTXSID7057608 Css NA 0.1148 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057608 Css NA 0.5194 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057608 Css NA 0.08232 mg/L PBTK NA 50% Rat Human -DTXSID7057608 Css NA 0.325 mg/L PBTK NA 95% Rat Human -DTXSID7057650 Clint NA 8.394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057650 Fup NA 0.5564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057650 Vd NA 2.3 L/kg 1compartment NA NA Human Human +DTXSID7057608 TK.Half.Life NA 1.238 hours 1compartment NA NA Rat Human +DTXSID7057608 Css NA 0.03836 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057608 Css NA 0.1627 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057608 Css NA 0.02619 mg/L PBTK NA 50% Rat Human +DTXSID7057608 Css NA 0.1023 mg/L PBTK NA 95% Rat Human +DTXSID7057650 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057650 Fup 0.412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057650 Vd NA 2.309 L/kg 1compartment NA NA Human Human DTXSID7057650 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057650 TK.Half.Life NA 4.03 hours 1compartment NA NA Human Human -DTXSID7057650 Css NA 0.1315 mg/L 3compartmentss NA 50% Human Human -DTXSID7057650 Css NA 1.011 mg/L 3compartmentss NA 95% Human Human -DTXSID7057650 Css NA 0.1133 mg/L PBTK NA 50% Human Human -DTXSID7057650 Css NA 0.7304 mg/L PBTK NA 95% Human Human -DTXSID7057650 Clint NA 8.394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057650 Fup NA 0.5564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057650 Vd NA 1.899 L/kg 1compartment NA NA Rat Human +DTXSID7057650 TK.Half.Life NA 6.589 hours 1compartment NA NA Human Human +DTXSID7057650 Css NA 0.245 mg/L 3compartmentss NA 50% Human Human +DTXSID7057650 Css NA 1.406 mg/L 3compartmentss NA 95% Human Human +DTXSID7057650 Css NA 0.1975 mg/L PBTK NA 50% Human Human +DTXSID7057650 Css NA 1.026 mg/L PBTK NA 95% Human Human +DTXSID7057650 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057650 Fup 0.412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057650 Vd NA 1.859 L/kg 1compartment NA NA Rat Human DTXSID7057650 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057650 TK.Half.Life NA 1.432 hours 1compartment NA NA Rat Human -DTXSID7057650 Css NA 0.06718 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057650 Css NA 0.4098 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057650 Css NA 0.05653 mg/L PBTK NA 50% Rat Human -DTXSID7057650 Css NA 0.2785 mg/L PBTK NA 95% Rat Human -DTXSID7057652 Clint NA 427.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057652 Fup NA 0.0423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057652 Vd NA 0.9924 L/kg 1compartment NA NA Human Human +DTXSID7057650 TK.Half.Life NA 2.178 hours 1compartment NA NA Rat Human +DTXSID7057650 Css NA 0.02818 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057650 Css NA 0.1227 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057650 Css NA 0.02316 mg/L PBTK NA 50% Rat Human +DTXSID7057650 Css NA 0.08739 mg/L PBTK NA 95% Rat Human +DTXSID7057652 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057652 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057652 Vd NA 1.337 L/kg 1compartment NA NA Human Human DTXSID7057652 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057652 TK.Half.Life NA 1.11 hours 1compartment NA NA Human Human -DTXSID7057652 Css NA 0.03914 mg/L 3compartmentss NA 50% Human Human -DTXSID7057652 Css NA 0.3725 mg/L 3compartmentss NA 95% Human Human -DTXSID7057652 Css NA 0.02434 mg/L PBTK NA 50% Human Human -DTXSID7057652 Css NA 0.2223 mg/L PBTK NA 95% Human Human -DTXSID7057652 Clint NA 427.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057652 Fup NA 0.0423 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057652 Vd NA 0.7541 L/kg 1compartment NA NA Rat Human +DTXSID7057652 TK.Half.Life NA 3.342 hours 1compartment NA NA Human Human +DTXSID7057652 Css NA 0.2533 mg/L 3compartmentss NA 50% Human Human +DTXSID7057652 Css NA 2.026 mg/L 3compartmentss NA 95% Human Human +DTXSID7057652 Css NA 0.1684 mg/L PBTK NA 50% Human Human +DTXSID7057652 Css NA 1.25 mg/L PBTK NA 95% Human Human +DTXSID7057652 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057652 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057652 Vd NA 1.037 L/kg 1compartment NA NA Rat Human DTXSID7057652 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057652 TK.Half.Life NA 0.3984 hours 1compartment NA NA Rat Human -DTXSID7057652 Css NA 0.02271 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057652 Css NA 0.1645 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057652 Css NA 0.01324 mg/L PBTK NA 50% Rat Human -DTXSID7057652 Css NA 0.092 mg/L PBTK NA 95% Rat Human -DTXSID7057654 Clint NA 32.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057654 Fup NA 0.1311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057654 Vd NA 0.8581 L/kg 1compartment NA NA Human Human +DTXSID7057652 TK.Half.Life NA 1.352 hours 1compartment NA NA Rat Human +DTXSID7057652 Css NA 0.03249 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057652 Css NA 0.2009 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057652 Css NA 0.02124 mg/L PBTK NA 50% Rat Human +DTXSID7057652 Css NA 0.1227 mg/L PBTK NA 95% Rat Human +DTXSID7057654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057654 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057654 Vd NA 1.11 L/kg 1compartment NA NA Human Human DTXSID7057654 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057654 TK.Half.Life NA 1.488 hours 1compartment NA NA Human Human -DTXSID7057654 Css NA 0.143 mg/L 3compartmentss NA 50% Human Human -DTXSID7057654 Css NA 1.191 mg/L 3compartmentss NA 95% Human Human -DTXSID7057654 Css NA 0.09396 mg/L PBTK NA 50% Human Human -DTXSID7057654 Css NA 0.7266 mg/L PBTK NA 95% Human Human -DTXSID7057654 Clint NA 32.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057654 Fup NA 0.1311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057654 Vd NA 0.6995 L/kg 1compartment NA NA Rat Human +DTXSID7057654 TK.Half.Life NA 1.446 hours 1compartment NA NA Human Human +DTXSID7057654 Css NA 0.06759 mg/L 3compartmentss NA 50% Human Human +DTXSID7057654 Css NA 0.5161 mg/L 3compartmentss NA 95% Human Human +DTXSID7057654 Css NA 0.05027 mg/L PBTK NA 50% Human Human +DTXSID7057654 Css NA 0.3537 mg/L PBTK NA 95% Human Human +DTXSID7057654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057654 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057654 Vd NA 0.9384 L/kg 1compartment NA NA Rat Human DTXSID7057654 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057654 TK.Half.Life NA 0.6558 hours 1compartment NA NA Rat Human -DTXSID7057654 Css NA 0.081 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057654 Css NA 0.5218 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057654 Css NA 0.05018 mg/L PBTK NA 50% Rat Human -DTXSID7057654 Css NA 0.2997 mg/L PBTK NA 95% Rat Human -DTXSID7057656 Clint NA 40.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057656 Fup NA 0.0285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057656 Vd NA 1.046 L/kg 1compartment NA NA Human Human -DTXSID7057656 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057656 TK.Half.Life NA 4.281 hours 1compartment NA NA Human Human -DTXSID7057656 Css NA 0.5838 mg/L 3compartmentss NA 50% Human Human -DTXSID7057656 Css NA 5.589 mg/L 3compartmentss NA 95% Human Human -DTXSID7057656 Css NA 0.3612 mg/L PBTK NA 50% Human Human -DTXSID7057656 Css NA 3.306 mg/L PBTK NA 95% Human Human -DTXSID7057656 Clint NA 40.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057656 Fup NA 0.0285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057656 Vd NA 0.7846 L/kg 1compartment NA NA Rat Human +DTXSID7057654 TK.Half.Life NA 0.6267 hours 1compartment NA NA Rat Human +DTXSID7057654 Css NA 0.008513 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057654 Css NA 0.04825 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057654 Css NA 0.006334 mg/L PBTK NA 50% Rat Human +DTXSID7057654 Css NA 0.03294 mg/L PBTK NA 95% Rat Human +DTXSID7057656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057656 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057656 Vd NA 1.544 L/kg 1compartment NA NA Human Human +DTXSID7057656 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7057656 TK.Half.Life NA 17.9 hours 1compartment NA NA Human Human +DTXSID7057656 Css NA 1.82 mg/L 3compartmentss NA 50% Human Human +DTXSID7057656 Css NA 16.6 mg/L 3compartmentss NA 95% Human Human +DTXSID7057656 Css NA 1.129 mg/L PBTK NA 50% Human Human +DTXSID7057656 Css NA 9.904 mg/L PBTK NA 95% Human Human +DTXSID7057656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057656 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057656 Vd NA 1.142 L/kg 1compartment NA NA Rat Human DTXSID7057656 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057656 TK.Half.Life NA 1.829 hours 1compartment NA NA Rat Human -DTXSID7057656 Css NA 0.3338 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057656 Css NA 2.565 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057656 Css NA 0.1923 mg/L PBTK NA 50% Rat Human -DTXSID7057656 Css NA 1.417 mg/L PBTK NA 95% Rat Human -DTXSID7057658 Clint NA 17.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057658 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057658 Vd NA 2.863 L/kg 1compartment NA NA Human Human -DTXSID7057658 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID7057658 TK.Half.Life NA 44.43 hours 1compartment NA NA Human Human -DTXSID7057658 Css NA 2.021 mg/L 3compartmentss NA 50% Human Human -DTXSID7057658 Css NA 12.7 mg/L 3compartmentss NA 95% Human Human -DTXSID7057658 Css NA 1.39 mg/L PBTK NA 50% Human Human -DTXSID7057658 Css NA 8.244 mg/L PBTK NA 95% Human Human -DTXSID7057658 Clint NA 17.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057658 Fup NA 0.0361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057658 Vd NA 2.144 L/kg 1compartment NA NA Rat Human -DTXSID7057658 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID7057658 TK.Half.Life NA 8.238 hours 1compartment NA NA Rat Human -DTXSID7057658 Css NA 1.13 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057658 Css NA 5.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057658 Css NA 0.734 mg/L PBTK NA 50% Rat Human -DTXSID7057658 Css NA 3.486 mg/L PBTK NA 95% Rat Human -DTXSID7057731 Clint NA 3.939 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057731 Fup NA 0.2009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057731 Vd NA 1.187 L/kg 1compartment NA NA Human Human -DTXSID7057731 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057731 TK.Half.Life NA 6.296 hours 1compartment NA NA Human Human -DTXSID7057731 Css NA 0.5728 mg/L 3compartmentss NA 50% Human Human -DTXSID7057731 Css NA 2.881 mg/L 3compartmentss NA 95% Human Human -DTXSID7057731 Css NA 0.4064 mg/L PBTK NA 50% Human Human -DTXSID7057731 Css NA 1.875 mg/L PBTK NA 95% Human Human -DTXSID7057731 Clint NA 3.939 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057731 Fup NA 0.2009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057731 Vd NA 0.9596 L/kg 1compartment NA NA Rat Human -DTXSID7057731 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057731 TK.Half.Life NA 2.676 hours 1compartment NA NA Rat Human -DTXSID7057731 Css NA 0.2843 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057731 Css NA 1.082 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057731 Css NA 0.1928 mg/L PBTK NA 50% Rat Human -DTXSID7057731 Css NA 0.6607 mg/L PBTK NA 95% Rat Human -DTXSID7057733 Clint NA 0.863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057733 Fup NA 0.5063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057733 Vd NA 3.758 L/kg 1compartment NA NA Human Human -DTXSID7057733 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID7057733 TK.Half.Life NA 19.31 hours 1compartment NA NA Human Human -DTXSID7057733 Css NA 0.3224 mg/L 3compartmentss NA 50% Human Human -DTXSID7057733 Css NA 2.472 mg/L 3compartmentss NA 95% Human Human -DTXSID7057733 Css NA 0.4362 mg/L PBTK NA 50% Human Human -DTXSID7057733 Css NA 2.053 mg/L PBTK NA 95% Human Human -DTXSID7057733 Clint NA 0.863 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057733 Fup NA 0.5063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057733 Vd NA 3.805 L/kg 1compartment NA NA Rat Human -DTXSID7057733 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7057733 TK.Half.Life NA 9.532 hours 1compartment NA NA Rat Human -DTXSID7057733 Css NA 0.1238 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057733 Css NA 0.8561 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057733 Css NA 0.1666 mg/L PBTK NA 50% Rat Human -DTXSID7057733 Css NA 0.6539 mg/L PBTK NA 95% Rat Human -DTXSID7057735 Clint NA 9.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057735 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057735 Vd NA 1.353 L/kg 1compartment NA NA Human Human +DTXSID7057656 TK.Half.Life NA 6.802 hours 1compartment NA NA Rat Human +DTXSID7057656 Css NA 0.2411 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057656 Css NA 1.703 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057656 Css NA 0.1457 mg/L PBTK NA 50% Rat Human +DTXSID7057656 Css NA 0.9987 mg/L PBTK NA 95% Rat Human +DTXSID7057658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057658 Fup 0.0192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057658 Vd NA 1.843 L/kg 1compartment NA NA Human Human +DTXSID7057658 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7057658 TK.Half.Life NA 18.58 hours 1compartment NA NA Human Human +DTXSID7057658 Css NA 1.527 mg/L 3compartmentss NA 50% Human Human +DTXSID7057658 Css NA 12.58 mg/L 3compartmentss NA 95% Human Human +DTXSID7057658 Css NA 0.9658 mg/L PBTK NA 50% Human Human +DTXSID7057658 Css NA 7.716 mg/L PBTK NA 95% Human Human +DTXSID7057658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057658 Fup 0.0192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057658 Vd NA 1.368 L/kg 1compartment NA NA Rat Human +DTXSID7057658 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7057658 TK.Half.Life NA 6.365 hours 1compartment NA NA Rat Human +DTXSID7057658 Css NA 0.1962 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057658 Css NA 1.373 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057658 Css NA 0.1215 mg/L PBTK NA 50% Rat Human +DTXSID7057658 Css NA 0.821 mg/L PBTK NA 95% Rat Human +DTXSID7057731 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057731 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057731 Vd NA 1.069 L/kg 1compartment NA NA Human Human +DTXSID7057731 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID7057731 TK.Half.Life NA 52.63 hours 1compartment NA NA Human Human +DTXSID7057731 Css NA 6.382 mg/L 3compartmentss NA 50% Human Human +DTXSID7057731 Css NA 27.16 mg/L 3compartmentss NA 95% Human Human +DTXSID7057731 Css NA 4.305 mg/L PBTK NA 50% Human Human +DTXSID7057731 Css NA 16.53 mg/L PBTK NA 95% Human Human +DTXSID7057731 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057731 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057731 Vd NA 0.8574 L/kg 1compartment NA NA Rat Human +DTXSID7057731 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID7057731 TK.Half.Life NA 12.97 hours 1compartment NA NA Rat Human +DTXSID7057731 Css NA 0.4098 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057731 Css NA 1.512 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057731 Css NA 0.2711 mg/L PBTK NA 50% Rat Human +DTXSID7057731 Css NA 0.8928 mg/L PBTK NA 95% Rat Human +DTXSID7057733 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057733 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057733 Vd NA 2.843 L/kg 1compartment NA NA Human Human +DTXSID7057733 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7057733 TK.Half.Life NA 5.445 hours 1compartment NA NA Human Human +DTXSID7057733 Css NA 0.1157 mg/L 3compartmentss NA 50% Human Human +DTXSID7057733 Css NA 0.8894 mg/L 3compartmentss NA 95% Human Human +DTXSID7057733 Css NA 0.1268 mg/L PBTK NA 50% Human Human +DTXSID7057733 Css NA 0.7496 mg/L PBTK NA 95% Human Human +DTXSID7057733 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057733 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057733 Vd NA 2.862 L/kg 1compartment NA NA Rat Human +DTXSID7057733 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7057733 TK.Half.Life NA 3.218 hours 1compartment NA NA Rat Human +DTXSID7057733 Css NA 0.01332 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057733 Css NA 0.07891 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057733 Css NA 0.01505 mg/L PBTK NA 50% Rat Human +DTXSID7057733 Css NA 0.06394 mg/L PBTK NA 95% Rat Human +DTXSID7057735 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057735 Fup 0.856 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057735 Vd NA 1.259 L/kg 1compartment NA NA Human Human DTXSID7057735 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057735 TK.Half.Life NA 1.123 hours 1compartment NA NA Human Human -DTXSID7057735 Css NA 0.04721 mg/L 3compartmentss NA 50% Human Human -DTXSID7057735 Css NA 0.5085 mg/L 3compartmentss NA 95% Human Human -DTXSID7057735 Css NA 0.04334 mg/L PBTK NA 50% Human Human -DTXSID7057735 Css NA 0.4013 mg/L PBTK NA 95% Human Human -DTXSID7057735 Clint NA 9.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057735 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057735 Vd NA 1.361 L/kg 1compartment NA NA Rat Human +DTXSID7057735 TK.Half.Life NA 9.62 hours 1compartment NA NA Human Human +DTXSID7057735 Css NA 0.8564 mg/L 3compartmentss NA 50% Human Human +DTXSID7057735 Css NA 5.355 mg/L 3compartmentss NA 95% Human Human +DTXSID7057735 Css NA 0.7672 mg/L PBTK NA 50% Human Human +DTXSID7057735 Css NA 3.559 mg/L PBTK NA 95% Human Human +DTXSID7057735 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057735 Fup 0.856 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057735 Vd NA 1.262 L/kg 1compartment NA NA Rat Human DTXSID7057735 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057735 TK.Half.Life NA 0.5757 hours 1compartment NA NA Rat Human -DTXSID7057735 Css NA 0.02267 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057735 Css NA 0.1979 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057735 Css NA 0.02075 mg/L PBTK NA 50% Rat Human -DTXSID7057735 Css NA 0.1364 mg/L PBTK NA 95% Rat Human -DTXSID7057737 Clint NA 1.076 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057737 Fup NA 0.3575 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057737 Vd NA 0.7927 L/kg 1compartment NA NA Human Human +DTXSID7057735 TK.Half.Life NA 3.259 hours 1compartment NA NA Rat Human +DTXSID7057735 Css NA 0.04982 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057735 Css NA 0.3109 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057735 Css NA 0.04562 mg/L PBTK NA 50% Rat Human +DTXSID7057735 Css NA 0.1994 mg/L PBTK NA 95% Rat Human +DTXSID7057737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057737 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057737 Vd NA 0.7393 L/kg 1compartment NA NA Human Human DTXSID7057737 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057737 TK.Half.Life NA 5.506 hours 1compartment NA NA Human Human -DTXSID7057737 Css NA 0.7425 mg/L 3compartmentss NA 50% Human Human -DTXSID7057737 Css NA 3.473 mg/L 3compartmentss NA 95% Human Human -DTXSID7057737 Css NA 0.5572 mg/L PBTK NA 50% Human Human -DTXSID7057737 Css NA 2.251 mg/L PBTK NA 95% Human Human -DTXSID7057737 Clint NA 1.076 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057737 Fup NA 0.3575 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057737 Vd NA 0.7245 L/kg 1compartment NA NA Rat Human +DTXSID7057737 TK.Half.Life NA 0.9388 hours 1compartment NA NA Human Human +DTXSID7057737 Css NA 0.0634 mg/L 3compartmentss NA 50% Human Human +DTXSID7057737 Css NA 0.4766 mg/L 3compartmentss NA 95% Human Human +DTXSID7057737 Css NA 0.04588 mg/L PBTK NA 50% Human Human +DTXSID7057737 Css NA 0.3162 mg/L PBTK NA 95% Human Human +DTXSID7057737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057737 Fup 0.316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057737 Vd NA 0.675 L/kg 1compartment NA NA Rat Human DTXSID7057737 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057737 TK.Half.Life NA 2.442 hours 1compartment NA NA Rat Human -DTXSID7057737 Css NA 0.3009 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057737 Css NA 1.188 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057737 Css NA 0.217 mg/L PBTK NA 50% Rat Human -DTXSID7057737 Css NA 0.7147 mg/L PBTK NA 95% Rat Human -DTXSID7057739 Clint NA 43.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057739 Fup NA 0.3504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057739 Vd NA 0.9291 L/kg 1compartment NA NA Human Human +DTXSID7057737 TK.Half.Life NA 0.4495 hours 1compartment NA NA Rat Human +DTXSID7057737 Css NA 0.008071 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057737 Css NA 0.04684 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057737 Css NA 0.005833 mg/L PBTK NA 50% Rat Human +DTXSID7057737 Css NA 0.03122 mg/L PBTK NA 95% Rat Human +DTXSID7057739 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057739 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057739 Vd NA 0.9503 L/kg 1compartment NA NA Human Human DTXSID7057739 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057739 TK.Half.Life NA 0.8906 hours 1compartment NA NA Human Human -DTXSID7057739 Css NA 0.03058 mg/L 3compartmentss NA 50% Human Human -DTXSID7057739 Css NA 0.2414 mg/L 3compartmentss NA 95% Human Human -DTXSID7057739 Css NA 0.02291 mg/L PBTK NA 50% Human Human -DTXSID7057739 Css NA 0.1675 mg/L PBTK NA 95% Human Human -DTXSID7057739 Clint NA 43.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057739 Fup NA 0.3504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057739 Vd NA 0.8231 L/kg 1compartment NA NA Rat Human +DTXSID7057739 TK.Half.Life NA 1.166 hours 1compartment NA NA Human Human +DTXSID7057739 Css NA 0.05932 mg/L 3compartmentss NA 50% Human Human +DTXSID7057739 Css NA 0.4576 mg/L 3compartmentss NA 95% Human Human +DTXSID7057739 Css NA 0.04461 mg/L PBTK NA 50% Human Human +DTXSID7057739 Css NA 0.3129 mg/L PBTK NA 95% Human Human +DTXSID7057739 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057739 Fup 0.335 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057739 Vd NA 0.8339 L/kg 1compartment NA NA Rat Human DTXSID7057739 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057739 TK.Half.Life NA 0.384 hours 1compartment NA NA Rat Human -DTXSID7057739 Css NA 0.01643 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057739 Css NA 0.1017 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057739 Css NA 0.01196 mg/L PBTK NA 50% Rat Human -DTXSID7057739 Css NA 0.06665 mg/L PBTK NA 95% Rat Human -DTXSID7057781 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057781 Fup NA 0.9311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057781 Vd NA 0.8842 L/kg 1compartment NA NA Human Human +DTXSID7057739 TK.Half.Life NA 0.5279 hours 1compartment NA NA Rat Human +DTXSID7057739 Css NA 0.007376 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057739 Css NA 0.04457 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057739 Css NA 0.005553 mg/L PBTK NA 50% Rat Human +DTXSID7057739 Css NA 0.03001 mg/L PBTK NA 95% Rat Human +DTXSID7057781 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057781 Fup 0.838 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057781 Vd NA 0.8638 L/kg 1compartment NA NA Human Human DTXSID7057781 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057781 TK.Half.Life NA 6.194 hours 1compartment NA NA Human Human -DTXSID7057781 Css NA 0.8465 mg/L 3compartmentss NA 50% Human Human -DTXSID7057781 Css NA 3.118 mg/L 3compartmentss NA 95% Human Human -DTXSID7057781 Css NA 0.7241 mg/L PBTK NA 50% Human Human -DTXSID7057781 Css NA 2.201 mg/L PBTK NA 95% Human Human -DTXSID7057781 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057781 Fup NA 0.9311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057781 Vd NA 0.8898 L/kg 1compartment NA NA Rat Human +DTXSID7057781 TK.Half.Life NA 0.6558 hours 1compartment NA NA Human Human +DTXSID7057781 Css NA 0.02544 mg/L 3compartmentss NA 50% Human Human +DTXSID7057781 Css NA 0.2675 mg/L 3compartmentss NA 95% Human Human +DTXSID7057781 Css NA 0.02089 mg/L PBTK NA 50% Human Human +DTXSID7057781 Css NA 0.1963 mg/L PBTK NA 95% Human Human +DTXSID7057781 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057781 Fup 0.838 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057781 Vd NA 0.8617 L/kg 1compartment NA NA Rat Human DTXSID7057781 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057781 TK.Half.Life NA 2.111 hours 1compartment NA NA Rat Human -DTXSID7057781 Css NA 0.2189 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057781 Css NA 0.7632 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057781 Css NA 0.183 mg/L PBTK NA 50% Rat Human -DTXSID7057781 Css NA 0.4955 mg/L PBTK NA 95% Rat Human -DTXSID7057783 Clint NA 10.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057783 Fup NA 0.1182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057783 Vd NA 2.632 L/kg 1compartment NA NA Human Human -DTXSID7057783 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7057783 TK.Half.Life NA 21.34 hours 1compartment NA NA Human Human -DTXSID7057783 Css NA 0.9969 mg/L 3compartmentss NA 50% Human Human -DTXSID7057783 Css NA 5.943 mg/L 3compartmentss NA 95% Human Human -DTXSID7057783 Css NA 0.6962 mg/L PBTK NA 50% Human Human -DTXSID7057783 Css NA 3.952 mg/L PBTK NA 95% Human Human -DTXSID7057783 Clint NA 10.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057783 Fup NA 0.1182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057783 Vd NA 1.985 L/kg 1compartment NA NA Rat Human -DTXSID7057783 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7057783 TK.Half.Life NA 4.944 hours 1compartment NA NA Rat Human -DTXSID7057783 Css NA 0.542 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057783 Css NA 2.374 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057783 Css NA 0.3601 mg/L PBTK NA 50% Rat Human -DTXSID7057783 Css NA 1.536 mg/L PBTK NA 95% Rat Human -DTXSID7057785 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057785 Fup NA 0.9494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057785 Vd NA 1.317 L/kg 1compartment NA NA Human Human +DTXSID7057781 TK.Half.Life NA 0.3154 hours 1compartment NA NA Rat Human +DTXSID7057781 Css NA 0.002966 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057781 Css NA 0.02594 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057781 Css NA 0.002532 mg/L PBTK NA 50% Rat Human +DTXSID7057781 Css NA 0.01812 mg/L PBTK NA 95% Rat Human +DTXSID7057783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057783 Fup 0.075 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057783 Vd NA 2.564 L/kg 1compartment NA NA Human Human +DTXSID7057783 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID7057783 TK.Half.Life NA 14.65 hours 1compartment NA NA Human Human +DTXSID7057783 Css NA 0.6729 mg/L 3compartmentss NA 50% Human Human +DTXSID7057783 Css NA 4.307 mg/L 3compartmentss NA 95% Human Human +DTXSID7057783 Css NA 0.4598 mg/L PBTK NA 50% Human Human +DTXSID7057783 Css NA 2.84 mg/L PBTK NA 95% Human Human +DTXSID7057783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057783 Fup 0.075 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057783 Vd NA 1.927 L/kg 1compartment NA NA Rat Human +DTXSID7057783 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7057783 TK.Half.Life NA 3.629 hours 1compartment NA NA Rat Human +DTXSID7057783 Css NA 0.08682 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057783 Css NA 0.4525 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057783 Css NA 0.05863 mg/L PBTK NA 50% Rat Human +DTXSID7057783 Css NA 0.2974 mg/L PBTK NA 95% Rat Human +DTXSID7057785 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057785 Fup 0.879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057785 Vd NA 1.207 L/kg 1compartment NA NA Human Human DTXSID7057785 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057785 TK.Half.Life NA 9.011 hours 1compartment NA NA Human Human -DTXSID7057785 Css NA 0.7818 mg/L 3compartmentss NA 50% Human Human -DTXSID7057785 Css NA 2.92 mg/L 3compartmentss NA 95% Human Human -DTXSID7057785 Css NA 0.7176 mg/L PBTK NA 50% Human Human -DTXSID7057785 Css NA 2.141 mg/L PBTK NA 95% Human Human -DTXSID7057785 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057785 Fup NA 0.9494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057785 Vd NA 1.337 L/kg 1compartment NA NA Rat Human +DTXSID7057785 TK.Half.Life NA 8.906 hours 1compartment NA NA Human Human +DTXSID7057785 Css NA 0.8428 mg/L 3compartmentss NA 50% Human Human +DTXSID7057785 Css NA 5.299 mg/L 3compartmentss NA 95% Human Human +DTXSID7057785 Css NA 0.75 mg/L PBTK NA 50% Human Human +DTXSID7057785 Css NA 3.517 mg/L PBTK NA 95% Human Human +DTXSID7057785 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057785 Fup 0.879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057785 Vd NA 1.227 L/kg 1compartment NA NA Rat Human DTXSID7057785 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057785 TK.Half.Life NA 3.108 hours 1compartment NA NA Rat Human -DTXSID7057785 Css NA 0.2005 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057785 Css NA 0.6885 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057785 Css NA 0.1808 mg/L PBTK NA 50% Rat Human -DTXSID7057785 Css NA 0.468 mg/L PBTK NA 95% Rat Human -DTXSID7057787 Clint NA 14.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057787 Fup NA 0.2846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057787 Vd NA 1.215 L/kg 1compartment NA NA Human Human +DTXSID7057785 TK.Half.Life NA 3.079 hours 1compartment NA NA Rat Human +DTXSID7057785 Css NA 0.04945 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057785 Css NA 0.2975 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057785 Css NA 0.04473 mg/L PBTK NA 50% Rat Human +DTXSID7057785 Css NA 0.1906 mg/L PBTK NA 95% Rat Human +DTXSID7057787 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057787 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057787 Vd NA 1.086 L/kg 1compartment NA NA Human Human DTXSID7057787 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057787 TK.Half.Life NA 2.035 hours 1compartment NA NA Human Human -DTXSID7057787 Css NA 0.1175 mg/L 3compartmentss NA 50% Human Human -DTXSID7057787 Css NA 0.7986 mg/L 3compartmentss NA 95% Human Human -DTXSID7057787 Css NA 0.08702 mg/L PBTK NA 50% Human Human -DTXSID7057787 Css NA 0.5528 mg/L PBTK NA 95% Human Human -DTXSID7057787 Clint NA 14.52 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057787 Fup NA 0.2846 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057787 Vd NA 1.006 L/kg 1compartment NA NA Rat Human +DTXSID7057787 TK.Half.Life NA 4.082 hours 1compartment NA NA Human Human +DTXSID7057787 Css NA 0.3684 mg/L 3compartmentss NA 50% Human Human +DTXSID7057787 Css NA 2.324 mg/L 3compartmentss NA 95% Human Human +DTXSID7057787 Css NA 0.2603 mg/L PBTK NA 50% Human Human +DTXSID7057787 Css NA 1.519 mg/L PBTK NA 95% Human Human +DTXSID7057787 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057787 Fup 0.197 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057787 Vd NA 0.8866 L/kg 1compartment NA NA Rat Human DTXSID7057787 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057787 TK.Half.Life NA 0.8787 hours 1compartment NA NA Rat Human -DTXSID7057787 Css NA 0.06294 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057787 Css NA 0.325 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057787 Css NA 0.04497 mg/L PBTK NA 50% Rat Human -DTXSID7057787 Css NA 0.2126 mg/L PBTK NA 95% Rat Human -DTXSID7057789 Clint NA 0.7855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057789 Fup NA 0.0151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057789 Vd NA 0.2165 L/kg 1compartment NA NA Human Human -DTXSID7057789 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID7057789 TK.Half.Life NA 40 hours 1compartment NA NA Human Human -DTXSID7057789 Css NA 32.02 mg/L 3compartmentss NA 50% Human Human -DTXSID7057789 Css NA 215.9 mg/L 3compartmentss NA 95% Human Human -DTXSID7057789 Css NA 18.84 mg/L PBTK NA 50% Human Human -DTXSID7057789 Css NA 125.1 mg/L PBTK NA 95% Human Human -DTXSID7057789 Clint NA 0.7855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057789 Fup NA 0.0151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057789 Vd NA 0.2049 L/kg 1compartment NA NA Rat Human -DTXSID7057789 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7057789 TK.Half.Life NA 18.22 hours 1compartment NA NA Rat Human -DTXSID7057789 Css NA 12.98 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057789 Css NA 77.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057789 Css NA 7.137 mg/L PBTK NA 50% Rat Human -DTXSID7057789 Css NA 41.9 mg/L PBTK NA 95% Rat Human -DTXSID7057810 Clint NA 29.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057810 Fup NA 0.0567 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057810 Vd NA 1.605 L/kg 1compartment NA NA Human Human +DTXSID7057787 TK.Half.Life NA 1.823 hours 1compartment NA NA Rat Human +DTXSID7057787 Css NA 0.04458 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057787 Css NA 0.1858 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057787 Css NA 0.0309 mg/L PBTK NA 50% Rat Human +DTXSID7057787 Css NA 0.1186 mg/L PBTK NA 95% Rat Human +DTXSID7057789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057789 Fup 0.0417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057789 Vd NA 0.2901 L/kg 1compartment NA NA Human Human +DTXSID7057789 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7057789 TK.Half.Life NA 1.457 hours 1compartment NA NA Human Human +DTXSID7057789 Css NA 0.7626 mg/L 3compartmentss NA 50% Human Human +DTXSID7057789 Css NA 6.307 mg/L 3compartmentss NA 95% Human Human +DTXSID7057789 Css NA 0.4596 mg/L PBTK NA 50% Human Human +DTXSID7057789 Css NA 3.738 mg/L PBTK NA 95% Human Human +DTXSID7057789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057789 Fup 0.0417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057789 Vd NA 0.2713 L/kg 1compartment NA NA Rat Human +DTXSID7057789 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7057789 TK.Half.Life NA 0.865 hours 1compartment NA NA Rat Human +DTXSID7057789 Css NA 0.1036 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057789 Css NA 0.6674 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057789 Css NA 0.06068 mg/L PBTK NA 50% Rat Human +DTXSID7057789 Css NA 0.3828 mg/L PBTK NA 95% Rat Human +DTXSID7057810 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057810 Fup 0.0881 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057810 Vd NA 1.894 L/kg 1compartment NA NA Human Human DTXSID7057810 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057810 TK.Half.Life NA 5.59 hours 1compartment NA NA Human Human -DTXSID7057810 Css NA 0.4296 mg/L 3compartmentss NA 50% Human Human -DTXSID7057810 Css NA 3.203 mg/L 3compartmentss NA 95% Human Human -DTXSID7057810 Css NA 0.2781 mg/L PBTK NA 50% Human Human -DTXSID7057810 Css NA 1.991 mg/L PBTK NA 95% Human Human -DTXSID7057810 Clint NA 29.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057810 Fup NA 0.0567 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057810 Vd NA 1.208 L/kg 1compartment NA NA Rat Human +DTXSID7057810 TK.Half.Life NA 6.595 hours 1compartment NA NA Human Human +DTXSID7057810 Css NA 0.3927 mg/L 3compartmentss NA 50% Human Human +DTXSID7057810 Css NA 2.779 mg/L 3compartmentss NA 95% Human Human +DTXSID7057810 Css NA 0.2628 mg/L PBTK NA 50% Human Human +DTXSID7057810 Css NA 1.78 mg/L PBTK NA 95% Human Human +DTXSID7057810 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057810 Fup 0.0881 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057810 Vd NA 1.433 L/kg 1compartment NA NA Rat Human DTXSID7057810 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057810 TK.Half.Life NA 2.087 hours 1compartment NA NA Rat Human -DTXSID7057810 Css NA 0.2433 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057810 Css NA 1.457 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057810 Css NA 0.1485 mg/L PBTK NA 50% Rat Human -DTXSID7057810 Css NA 0.8433 mg/L PBTK NA 95% Rat Human -DTXSID7057812 Clint NA 37.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057812 Fup NA 0.0143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057812 Vd NA 3.012 L/kg 1compartment NA NA Human Human -DTXSID7057812 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID7057812 TK.Half.Life NA 40.35 hours 1compartment NA NA Human Human -DTXSID7057812 Css NA 1.666 mg/L 3compartmentss NA 50% Human Human -DTXSID7057812 Css NA 10.46 mg/L 3compartmentss NA 95% Human Human -DTXSID7057812 Css NA 1.15 mg/L PBTK NA 50% Human Human -DTXSID7057812 Css NA 6.968 mg/L PBTK NA 95% Human Human -DTXSID7057812 Clint NA 37.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057812 Fup NA 0.0143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057812 Vd NA 2.257 L/kg 1compartment NA NA Rat Human -DTXSID7057812 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID7057812 TK.Half.Life NA 6.527 hours 1compartment NA NA Rat Human -DTXSID7057812 Css NA 0.9374 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057812 Css NA 5.054 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057812 Css NA 0.614 mg/L PBTK NA 50% Rat Human -DTXSID7057812 Css NA 3.228 mg/L PBTK NA 95% Rat Human -DTXSID7057814 Clint NA 81.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057814 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057814 Vd NA 38.94 L/kg 1compartment NA NA Human Human -DTXSID7057814 Days.Css NA 63 Days PBTK NA NA Human Human -DTXSID7057814 TK.Half.Life NA 310.7 hours 1compartment NA NA Human Human -DTXSID7057814 Css NA 0.1554 mg/L 3compartmentss NA 50% Human Human -DTXSID7057814 Css NA 0.9348 mg/L 3compartmentss NA 95% Human Human -DTXSID7057814 Css NA 0.6536 mg/L PBTK NA 50% Human Human -DTXSID7057814 Css NA 3.684 mg/L PBTK NA 95% Human Human -DTXSID7057814 Clint NA 81.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057814 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057814 Vd NA 32.5 L/kg 1compartment NA NA Rat Human -DTXSID7057814 Days.Css NA 41 Days PBTK NA NA Rat Human -DTXSID7057814 TK.Half.Life NA 46.27 hours 1compartment NA NA Rat Human -DTXSID7057814 Css NA 0.08019 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057814 Css NA 0.3509 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057814 Css NA 0.3512 mg/L PBTK NA 50% Rat Human -DTXSID7057814 Css NA 1.499 mg/L PBTK NA 95% Rat Human -DTXSID7057816 Clint NA 38.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057816 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057816 Vd NA 1.592 L/kg 1compartment NA NA Human Human +DTXSID7057810 TK.Half.Life NA 2.265 hours 1compartment NA NA Rat Human +DTXSID7057810 Css NA 0.05094 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057810 Css NA 0.2832 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057810 Css NA 0.03341 mg/L PBTK NA 50% Rat Human +DTXSID7057810 Css NA 0.1775 mg/L PBTK NA 95% Rat Human +DTXSID7057812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057812 Fup 0.00409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057812 Vd NA 2.911 L/kg 1compartment NA NA Human Human +DTXSID7057812 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID7057812 TK.Half.Life NA 81.23 hours 1compartment NA NA Human Human +DTXSID7057812 Css NA 3.534 mg/L 3compartmentss NA 50% Human Human +DTXSID7057812 Css NA 22.58 mg/L 3compartmentss NA 95% Human Human +DTXSID7057812 Css NA 2.394 mg/L PBTK NA 50% Human Human +DTXSID7057812 Css NA 15.24 mg/L PBTK NA 95% Human Human +DTXSID7057812 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057812 Fup 0.00409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057812 Vd NA 2.177 L/kg 1compartment NA NA Rat Human +DTXSID7057812 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID7057812 TK.Half.Life NA 14.09 hours 1compartment NA NA Rat Human +DTXSID7057812 Css NA 0.462 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057812 Css NA 2.564 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057812 Css NA 0.3091 mg/L PBTK NA 50% Rat Human +DTXSID7057812 Css NA 1.707 mg/L PBTK NA 95% Rat Human +DTXSID7057816 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057816 Fup 0.0672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057816 Vd NA 2.205 L/kg 1compartment NA NA Human Human DTXSID7057816 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID7057816 TK.Half.Life NA 5.649 hours 1compartment NA NA Human Human -DTXSID7057816 Css NA 0.4598 mg/L 3compartmentss NA 50% Human Human -DTXSID7057816 Css NA 3.899 mg/L 3compartmentss NA 95% Human Human -DTXSID7057816 Css NA 0.2948 mg/L PBTK NA 50% Human Human -DTXSID7057816 Css NA 2.352 mg/L PBTK NA 95% Human Human -DTXSID7057816 Clint NA 38.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057816 Fup NA 0.0404 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057816 Vd NA 1.193 L/kg 1compartment NA NA Rat Human +DTXSID7057816 TK.Half.Life NA 10.65 hours 1compartment NA NA Human Human +DTXSID7057816 Css NA 0.5659 mg/L 3compartmentss NA 50% Human Human +DTXSID7057816 Css NA 3.705 mg/L 3compartmentss NA 95% Human Human +DTXSID7057816 Css NA 0.38 mg/L PBTK NA 50% Human Human +DTXSID7057816 Css NA 2.402 mg/L PBTK NA 95% Human Human +DTXSID7057816 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057816 Fup 0.0672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057816 Vd NA 1.658 L/kg 1compartment NA NA Rat Human DTXSID7057816 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID7057816 TK.Half.Life NA 2.112 hours 1compartment NA NA Rat Human -DTXSID7057816 Css NA 0.2625 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057816 Css NA 1.785 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057816 Css NA 0.1578 mg/L PBTK NA 50% Rat Human -DTXSID7057816 Css NA 1.02 mg/L PBTK NA 95% Rat Human -DTXSID7057818 Clint NA 49.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057818 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID7057818 Vd NA 2.874 L/kg 1compartment NA NA Human Human -DTXSID7057818 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID7057818 TK.Half.Life NA 24.78 hours 1compartment NA NA Human Human -DTXSID7057818 Css NA 1.082 mg/L 3compartmentss NA 50% Human Human -DTXSID7057818 Css NA 7.276 mg/L 3compartmentss NA 95% Human Human -DTXSID7057818 Css NA 0.7321 mg/L PBTK NA 50% Human Human -DTXSID7057818 Css NA 4.721 mg/L PBTK NA 95% Human Human -DTXSID7057818 Clint NA 49.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057818 Fup NA 0.0158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID7057818 Vd NA 2.148 L/kg 1compartment NA NA Rat Human -DTXSID7057818 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID7057818 TK.Half.Life NA 4.722 hours 1compartment NA NA Rat Human -DTXSID7057818 Css NA 0.6086 mg/L 3compartmentss NA 50% Rat Human -DTXSID7057818 Css NA 3.328 mg/L 3compartmentss NA 95% Rat Human -DTXSID7057818 Css NA 0.3936 mg/L PBTK NA 50% Rat Human -DTXSID7057818 Css NA 2.123 mg/L PBTK NA 95% Rat Human +DTXSID7057816 TK.Half.Life NA 3.206 hours 1compartment NA NA Rat Human +DTXSID7057816 Css NA 0.07259 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057816 Css NA 0.3914 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057816 Css NA 0.04818 mg/L PBTK NA 50% Rat Human +DTXSID7057816 Css NA 0.2468 mg/L PBTK NA 95% Rat Human +DTXSID7057818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057818 Fup 0.00558 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7057818 Vd NA 2.915 L/kg 1compartment NA NA Human Human +DTXSID7057818 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID7057818 TK.Half.Life NA 76.28 hours 1compartment NA NA Human Human +DTXSID7057818 Css NA 3.382 mg/L 3compartmentss NA 50% Human Human +DTXSID7057818 Css NA 22.2 mg/L 3compartmentss NA 95% Human Human +DTXSID7057818 Css NA 2.298 mg/L PBTK NA 50% Human Human +DTXSID7057818 Css NA 14.54 mg/L PBTK NA 95% Human Human +DTXSID7057818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057818 Fup 0.00558 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7057818 Vd NA 2.179 L/kg 1compartment NA NA Rat Human +DTXSID7057818 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID7057818 TK.Half.Life NA 13.18 hours 1compartment NA NA Rat Human +DTXSID7057818 Css NA 0.4435 mg/L 3compartmentss NA 50% Rat Human +DTXSID7057818 Css NA 2.58 mg/L 3compartmentss NA 95% Rat Human +DTXSID7057818 Css NA 0.2958 mg/L PBTK NA 50% Rat Human +DTXSID7057818 Css NA 1.655 mg/L PBTK NA 95% Rat Human +DTXSID7058626 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7058626 Fup 0.606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7058626 Vd NA 0.6122 L/kg 1compartment NA NA Human Human +DTXSID7058626 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7058626 TK.Half.Life NA 6.539 hours 1compartment NA NA Human Human +DTXSID7058626 Css NA 1.22 mg/L 3compartmentss NA 50% Human Human +DTXSID7058626 Css NA 8.035 mg/L 3compartmentss NA 95% Human Human +DTXSID7058626 Css NA 0.9499 mg/L PBTK NA 50% Human Human +DTXSID7058626 Css NA 5.01 mg/L PBTK NA 95% Human Human +DTXSID7058626 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7058626 Fup 0.606 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7058626 Vd NA 0.6338 L/kg 1compartment NA NA Rat Human +DTXSID7058626 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7058626 TK.Half.Life NA 2.306 hours 1compartment NA NA Rat Human +DTXSID7058626 Css NA 0.07383 mg/L 3compartmentss NA 50% Rat Human +DTXSID7058626 Css NA 0.4716 mg/L 3compartmentss NA 95% Rat Human +DTXSID7058626 Css NA 0.05734 mg/L PBTK NA 50% Rat Human +DTXSID7058626 Css NA 0.2845 mg/L PBTK NA 95% Rat Human +DTXSID7058705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7058705 Fup 0.055 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7058705 Vd NA 1.553 L/kg 1compartment NA NA Human Human +DTXSID7058705 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7058705 TK.Half.Life NA 6.876 hours 1compartment NA NA Human Human +DTXSID7058705 Css NA 0.5794 mg/L 3compartmentss NA 50% Human Human +DTXSID7058705 Css NA 4.183 mg/L 3compartmentss NA 95% Human Human +DTXSID7058705 Css NA 0.3726 mg/L PBTK NA 50% Human Human +DTXSID7058705 Css NA 2.59 mg/L PBTK NA 95% Human Human +DTXSID7058705 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7058705 Fup 0.055 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7058705 Vd NA 1.169 L/kg 1compartment NA NA Rat Human +DTXSID7058705 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7058705 TK.Half.Life NA 2.616 hours 1compartment NA NA Rat Human +DTXSID7058705 Css NA 0.07515 mg/L 3compartmentss NA 50% Rat Human +DTXSID7058705 Css NA 0.4548 mg/L 3compartmentss NA 95% Rat Human +DTXSID7058705 Css NA 0.04724 mg/L PBTK NA 50% Rat Human +DTXSID7058705 Css NA 0.2754 mg/L PBTK NA 95% Rat Human +DTXSID7059224 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7059224 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7059224 Vd NA 2.082 L/kg 1compartment NA NA Human Human +DTXSID7059224 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7059224 TK.Half.Life NA 3.556 hours 1compartment NA NA Human Human +DTXSID7059224 Css NA 0.1144 mg/L 3compartmentss NA 50% Human Human +DTXSID7059224 Css NA 0.7808 mg/L 3compartmentss NA 95% Human Human +DTXSID7059224 Css NA 0.08603 mg/L PBTK NA 50% Human Human +DTXSID7059224 Css NA 0.5463 mg/L PBTK NA 95% Human Human +DTXSID7059224 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7059224 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7059224 Vd NA 1.634 L/kg 1compartment NA NA Rat Human +DTXSID7059224 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7059224 TK.Half.Life NA 1.227 hours 1compartment NA NA Rat Human +DTXSID7059224 Css NA 0.01415 mg/L 3compartmentss NA 50% Rat Human +DTXSID7059224 Css NA 0.07311 mg/L 3compartmentss NA 95% Rat Human +DTXSID7059224 Css NA 0.01071 mg/L PBTK NA 50% Rat Human +DTXSID7059224 Css NA 0.0512 mg/L PBTK NA 95% Rat Human +DTXSID7059806 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7059806 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7059806 Vd NA 0.5469 L/kg 1compartment NA NA Human Human +DTXSID7059806 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7059806 TK.Half.Life NA 1.165 hours 1compartment NA NA Human Human +DTXSID7059806 Css NA 0.198 mg/L 3compartmentss NA 50% Human Human +DTXSID7059806 Css NA 1.658 mg/L 3compartmentss NA 95% Human Human +DTXSID7059806 Css NA 0.1373 mg/L PBTK NA 50% Human Human +DTXSID7059806 Css NA 1.047 mg/L PBTK NA 95% Human Human +DTXSID7059806 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7059806 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7059806 Vd NA 0.5375 L/kg 1compartment NA NA Rat Human +DTXSID7059806 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7059806 TK.Half.Life NA 0.6723 hours 1compartment NA NA Rat Human +DTXSID7059806 Css NA 0.02352 mg/L 3compartmentss NA 50% Rat Human +DTXSID7059806 Css NA 0.1625 mg/L 3compartmentss NA 95% Rat Human +DTXSID7059806 Css NA 0.016 mg/L PBTK NA 50% Rat Human +DTXSID7059806 Css NA 0.1019 mg/L PBTK NA 95% Rat Human +DTXSID7062085 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7062085 Fup 0.786 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7062085 Vd NA 0.9003 L/kg 1compartment NA NA Human Human +DTXSID7062085 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7062085 TK.Half.Life NA 7.571 hours 1compartment NA NA Human Human +DTXSID7062085 Css NA 0.9604 mg/L 3compartmentss NA 50% Human Human +DTXSID7062085 Css NA 5.951 mg/L 3compartmentss NA 95% Human Human +DTXSID7062085 Css NA 0.8059 mg/L PBTK NA 50% Human Human +DTXSID7062085 Css NA 3.882 mg/L PBTK NA 95% Human Human +DTXSID7062085 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7062085 Fup 0.786 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7062085 Vd NA 0.7479 L/kg 1compartment NA NA Rat Human +DTXSID7062085 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7062085 TK.Half.Life NA 2.714 hours 1compartment NA NA Rat Human +DTXSID7062085 Css NA 0.0727 mg/L 3compartmentss NA 50% Rat Human +DTXSID7062085 Css NA 0.4689 mg/L 3compartmentss NA 95% Rat Human +DTXSID7062085 Css NA 0.05787 mg/L PBTK NA 50% Rat Human +DTXSID7062085 Css NA 0.285 mg/L PBTK NA 95% Rat Human +DTXSID7062875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7062875 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7062875 Vd NA 141 L/kg 1compartment NA NA Human Human +DTXSID7062875 Days.Css NA 1101 Days PBTK NA NA Human Human +DTXSID7062875 TK.Half.Life NA 4151 hours 1compartment NA NA Human Human +DTXSID7062875 Css NA 0.07246 mg/L 3compartmentss NA 50% Human Human +DTXSID7062875 Css NA 0.4933 mg/L 3compartmentss NA 95% Human Human +DTXSID7062875 Css NA 1.308 mg/L PBTK NA 50% Human Human +DTXSID7062875 Css NA 7.834 mg/L PBTK NA 95% Human Human +DTXSID7062875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7062875 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7062875 Vd NA 123.2 L/kg 1compartment NA NA Rat Human +DTXSID7062875 Days.Css NA 651 Days PBTK NA NA Rat Human +DTXSID7062875 TK.Half.Life NA 623.9 hours 1compartment NA NA Rat Human +DTXSID7062875 Css NA 0.0007049 mg/L 3compartmentss NA 50% Rat Human +DTXSID7062875 Css NA 0.004252 mg/L 3compartmentss NA 95% Rat Human +DTXSID7062875 Css NA 0.01367 mg/L PBTK NA 50% Rat Human +DTXSID7062875 Css NA 0.08208 mg/L PBTK NA 95% Rat Human +DTXSID7064235 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7064235 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7064235 Vd NA 0.5515 L/kg 1compartment NA NA Human Human +DTXSID7064235 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7064235 TK.Half.Life NA 3.199 hours 1compartment NA NA Human Human +DTXSID7064235 Css NA 0.7994 mg/L 3compartmentss NA 50% Human Human +DTXSID7064235 Css NA 5.565 mg/L 3compartmentss NA 95% Human Human +DTXSID7064235 Css NA 0.509 mg/L PBTK NA 50% Human Human +DTXSID7064235 Css NA 3.366 mg/L PBTK NA 95% Human Human +DTXSID7064235 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7064235 Fup 0.112 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7064235 Vd NA 0.4633 L/kg 1compartment NA NA Rat Human +DTXSID7064235 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7064235 TK.Half.Life NA 1.599 hours 1compartment NA NA Rat Human +DTXSID7064235 Css NA 0.09798 mg/L 3compartmentss NA 50% Rat Human +DTXSID7064235 Css NA 0.5112 mg/L 3compartmentss NA 95% Rat Human +DTXSID7064235 Css NA 0.06016 mg/L PBTK NA 50% Rat Human +DTXSID7064235 Css NA 0.2977 mg/L PBTK NA 95% Rat Human +DTXSID7064788 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7064788 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7064788 Vd NA 3.111 L/kg 1compartment NA NA Human Human +DTXSID7064788 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID7064788 TK.Half.Life NA 89.47 hours 1compartment NA NA Human Human +DTXSID7064788 Css NA 1.866 mg/L 3compartmentss NA 50% Human Human +DTXSID7064788 Css NA 12.49 mg/L 3compartmentss NA 95% Human Human +DTXSID7064788 Css NA 1.299 mg/L PBTK NA 50% Human Human +DTXSID7064788 Css NA 8.442 mg/L PBTK NA 95% Human Human +DTXSID7064788 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7064788 Fup 0.0169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7064788 Vd NA 2.329 L/kg 1compartment NA NA Rat Human +DTXSID7064788 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID7064788 TK.Half.Life NA 12.18 hours 1compartment NA NA Rat Human +DTXSID7064788 Css NA 0.0204 mg/L 3compartmentss NA 50% Rat Human +DTXSID7064788 Css NA 0.1241 mg/L 3compartmentss NA 95% Rat Human +DTXSID7064788 Css NA 0.01356 mg/L PBTK NA 50% Rat Human +DTXSID7064788 Css NA 0.08122 mg/L PBTK NA 95% Rat Human +DTXSID7074325 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7074325 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7074325 Vd NA 1.861 L/kg 1compartment NA NA Human Human +DTXSID7074325 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7074325 TK.Half.Life NA 4.063 hours 1compartment NA NA Human Human +DTXSID7074325 Css NA 0.1692 mg/L 3compartmentss NA 50% Human Human +DTXSID7074325 Css NA 1.137 mg/L 3compartmentss NA 95% Human Human +DTXSID7074325 Css NA 0.1209 mg/L PBTK NA 50% Human Human +DTXSID7074325 Css NA 0.7651 mg/L PBTK NA 95% Human Human +DTXSID7074325 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7074325 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7074325 Vd NA 1.434 L/kg 1compartment NA NA Rat Human +DTXSID7074325 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7074325 TK.Half.Life NA 1.439 hours 1compartment NA NA Rat Human +DTXSID7074325 Css NA 0.02162 mg/L 3compartmentss NA 50% Rat Human +DTXSID7074325 Css NA 0.1097 mg/L 3compartmentss NA 95% Rat Human +DTXSID7074325 Css NA 0.01525 mg/L PBTK NA 50% Rat Human +DTXSID7074325 Css NA 0.07386 mg/L PBTK NA 95% Rat Human +DTXSID7074747 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7074747 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID7074747 Vd NA 1.196 L/kg 1compartment NA NA Human Human +DTXSID7074747 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID7074747 TK.Half.Life NA 2.536 hours 1compartment NA NA Human Human +DTXSID7074747 Css NA 0.1654 mg/L 3compartmentss NA 50% Human Human +DTXSID7074747 Css NA 1.121 mg/L 3compartmentss NA 95% Human Human +DTXSID7074747 Css NA 0.1308 mg/L PBTK NA 50% Human Human +DTXSID7074747 Css NA 0.774 mg/L PBTK NA 95% Human Human +DTXSID7074747 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7074747 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID7074747 Vd NA 1.028 L/kg 1compartment NA NA Rat Human +DTXSID7074747 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID7074747 TK.Half.Life NA 1.154 hours 1compartment NA NA Rat Human +DTXSID7074747 Css NA 0.01922 mg/L 3compartmentss NA 50% Rat Human +DTXSID7074747 Css NA 0.09732 mg/L 3compartmentss NA 95% Rat Human +DTXSID7074747 Css NA 0.01515 mg/L PBTK NA 50% Rat Human +DTXSID7074747 Css NA 0.06546 mg/L PBTK NA 95% Rat Human +DTXSID70860597 Clint 22 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID70860597 Fup 0.015 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70860597 Vd NA 0.5557 L/kg 1compartment NA NA Human Human +DTXSID70860597 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70860597 TK.Half.Life NA 5.563 hours 1compartment NA NA Human Human +DTXSID70860597 Css NA 1.624 mg/L 3compartmentss NA 50% Human Human +DTXSID70860597 Css NA 17.17 mg/L 3compartmentss NA 95% Human Human +DTXSID70860597 Css NA 0.9962 mg/L PBTK NA 50% Human Human +DTXSID70860597 Css NA 10.1 mg/L PBTK NA 95% Human Human +DTXSID70860597 Clint 22 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID70860597 Fup 0.015 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70860597 Vd NA 0.5354 L/kg 1compartment NA NA Rat Human +DTXSID70860597 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70860597 TK.Half.Life NA 3.551 hours 1compartment NA NA Rat Human +DTXSID70860597 Css NA 0.2208 mg/L 3compartmentss NA 50% Rat Human +DTXSID70860597 Css NA 1.821 mg/L 3compartmentss NA 95% Rat Human +DTXSID70860597 Css NA 0.1306 mg/L PBTK NA 50% Rat Human +DTXSID70860597 Css NA 1.034 mg/L PBTK NA 95% Rat Human +DTXSID70861120 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70861120 Fup 0.0534 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70861120 Vd NA 0.8369 L/kg 1compartment NA NA Human Human +DTXSID70861120 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70861120 TK.Half.Life NA 9.485 hours 1compartment NA NA Human Human +DTXSID70861120 Css NA 1.791 mg/L 3compartmentss NA 50% Human Human +DTXSID70861120 Css NA 12.09 mg/L 3compartmentss NA 95% Human Human +DTXSID70861120 Css NA 1.118 mg/L PBTK NA 50% Human Human +DTXSID70861120 Css NA 7.179 mg/L PBTK NA 95% Human Human +DTXSID70861120 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70861120 Fup 0.0534 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70861120 Vd NA 0.6471 L/kg 1compartment NA NA Rat Human +DTXSID70861120 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70861120 TK.Half.Life NA 4.289 hours 1compartment NA NA Rat Human +DTXSID70861120 Css NA 0.2229 mg/L 3compartmentss NA 50% Rat Human +DTXSID70861120 Css NA 1.14 mg/L 3compartmentss NA 95% Rat Human +DTXSID70861120 Css NA 0.1342 mg/L PBTK NA 50% Rat Human +DTXSID70861120 Css NA 0.6566 mg/L PBTK NA 95% Rat Human +DTXSID70861706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70861706 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70861706 Vd NA 1.381 L/kg 1compartment NA NA Human Human +DTXSID70861706 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70861706 TK.Half.Life NA 1.504 hours 1compartment NA NA Human Human +DTXSID70861706 Css NA 0.0479 mg/L 3compartmentss NA 50% Human Human +DTXSID70861706 Css NA 0.3713 mg/L 3compartmentss NA 95% Human Human +DTXSID70861706 Css NA 0.03848 mg/L PBTK NA 50% Human Human +DTXSID70861706 Css NA 0.2689 mg/L PBTK NA 95% Human Human +DTXSID70861706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70861706 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70861706 Vd NA 1.166 L/kg 1compartment NA NA Rat Human +DTXSID70861706 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70861706 TK.Half.Life NA 0.6222 hours 1compartment NA NA Rat Human +DTXSID70861706 Css NA 0.005829 mg/L 3compartmentss NA 50% Rat Human +DTXSID70861706 Css NA 0.03665 mg/L 3compartmentss NA 95% Rat Human +DTXSID70861706 Css NA 0.004766 mg/L PBTK NA 50% Rat Human +DTXSID70861706 Css NA 0.02592 mg/L PBTK NA 95% Rat Human +DTXSID70864232 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70864232 Fup 0.0281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70864232 Vd NA 3.073 L/kg 1compartment NA NA Human Human +DTXSID70864232 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID70864232 TK.Half.Life NA 67.96 hours 1compartment NA NA Human Human +DTXSID70864232 Css NA 2.647 mg/L 3compartmentss NA 50% Human Human +DTXSID70864232 Css NA 17.29 mg/L 3compartmentss NA 95% Human Human +DTXSID70864232 Css NA 1.828 mg/L PBTK NA 50% Human Human +DTXSID70864232 Css NA 11.48 mg/L PBTK NA 95% Human Human +DTXSID70864232 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70864232 Fup 0.0281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70864232 Vd NA 2.302 L/kg 1compartment NA NA Rat Human +DTXSID70864232 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID70864232 TK.Half.Life NA 9.874 hours 1compartment NA NA Rat Human +DTXSID70864232 Css NA 0.3429 mg/L 3compartmentss NA 50% Rat Human +DTXSID70864232 Css NA 1.938 mg/L 3compartmentss NA 95% Rat Human +DTXSID70864232 Css NA 0.2342 mg/L PBTK NA 50% Rat Human +DTXSID70864232 Css NA 1.298 mg/L PBTK NA 95% Rat Human +DTXSID70870176 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70870176 Fup 0.0038 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70870176 Vd NA 1.786 L/kg 1compartment NA NA Human Human +DTXSID70870176 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID70870176 TK.Half.Life NA 46.87 hours 1compartment NA NA Human Human +DTXSID70870176 Css NA 4.199 mg/L 3compartmentss NA 50% Human Human +DTXSID70870176 Css NA 34.1 mg/L 3compartmentss NA 95% Human Human +DTXSID70870176 Css NA 2.636 mg/L PBTK NA 50% Human Human +DTXSID70870176 Css NA 21.12 mg/L PBTK NA 95% Human Human +DTXSID70870176 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70870176 Fup 0.0038 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70870176 Vd NA 1.317 L/kg 1compartment NA NA Rat Human +DTXSID70870176 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID70870176 TK.Half.Life NA 16.37 hours 1compartment NA NA Rat Human +DTXSID70870176 Css NA 0.5617 mg/L 3compartmentss NA 50% Rat Human +DTXSID70870176 Css NA 3.463 mg/L 3compartmentss NA 95% Rat Human +DTXSID70870176 Css NA 0.3424 mg/L PBTK NA 50% Rat Human +DTXSID70870176 Css NA 2.043 mg/L PBTK NA 95% Rat Human +DTXSID70870252 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70870252 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70870252 Vd NA 0.9338 L/kg 1compartment NA NA Human Human +DTXSID70870252 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70870252 TK.Half.Life NA 3.426 hours 1compartment NA NA Human Human +DTXSID70870252 Css NA 0.3176 mg/L 3compartmentss NA 50% Human Human +DTXSID70870252 Css NA 1.854 mg/L 3compartmentss NA 95% Human Human +DTXSID70870252 Css NA 0.2193 mg/L PBTK NA 50% Human Human +DTXSID70870252 Css NA 1.193 mg/L PBTK NA 95% Human Human +DTXSID70870252 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70870252 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70870252 Vd NA 0.7584 L/kg 1compartment NA NA Rat Human +DTXSID70870252 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70870252 TK.Half.Life NA 1.542 hours 1compartment NA NA Rat Human +DTXSID70870252 Css NA 0.01438 mg/L 3compartmentss NA 50% Rat Human +DTXSID70870252 Css NA 0.09905 mg/L 3compartmentss NA 95% Rat Human +DTXSID70870252 Css NA 0.009797 mg/L PBTK NA 50% Rat Human +DTXSID70870252 Css NA 0.06202 mg/L PBTK NA 95% Rat Human +DTXSID70870934 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70870934 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70870934 Vd NA 2.76 L/kg 1compartment NA NA Human Human +DTXSID70870934 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70870934 TK.Half.Life NA 8.885 hours 1compartment NA NA Human Human +DTXSID70870934 Css NA 0.2894 mg/L 3compartmentss NA 50% Human Human +DTXSID70870934 Css NA 1.826 mg/L 3compartmentss NA 95% Human Human +DTXSID70870934 Css NA 0.2098 mg/L PBTK NA 50% Human Human +DTXSID70870934 Css NA 1.266 mg/L PBTK NA 95% Human Human +DTXSID70870934 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70870934 Fup 0.228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70870934 Vd NA 2.095 L/kg 1compartment NA NA Rat Human +DTXSID70870934 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70870934 TK.Half.Life NA 2.097 hours 1compartment NA NA Rat Human +DTXSID70870934 Css NA 0.03672 mg/L 3compartmentss NA 50% Rat Human +DTXSID70870934 Css NA 0.1817 mg/L 3compartmentss NA 95% Rat Human +DTXSID70870934 Css NA 0.02654 mg/L PBTK NA 50% Rat Human +DTXSID70870934 Css NA 0.1288 mg/L PBTK NA 95% Rat Human +DTXSID70872933 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70872933 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70872933 Vd NA 1.315 L/kg 1compartment NA NA Human Human +DTXSID70872933 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70872933 TK.Half.Life NA 2.386 hours 1compartment NA NA Human Human +DTXSID70872933 Css NA 0.1194 mg/L 3compartmentss NA 50% Human Human +DTXSID70872933 Css NA 0.9685 mg/L 3compartmentss NA 95% Human Human +DTXSID70872933 Css NA 0.0921 mg/L PBTK NA 50% Human Human +DTXSID70872933 Css NA 0.6511 mg/L PBTK NA 95% Human Human +DTXSID70872933 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70872933 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70872933 Vd NA 1.282 L/kg 1compartment NA NA Rat Human +DTXSID70872933 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70872933 TK.Half.Life NA 0.9063 hours 1compartment NA NA Rat Human +DTXSID70872933 Css NA 0.004104 mg/L 3compartmentss NA 50% Rat Human +DTXSID70872933 Css NA 0.03716 mg/L 3compartmentss NA 95% Rat Human +DTXSID70872933 Css NA 0.003406 mg/L PBTK NA 50% Rat Human +DTXSID70872933 Css NA 0.02547 mg/L PBTK NA 95% Rat Human +DTXSID70873208 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70873208 Fup 0.78 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70873208 Vd NA 0.5823 L/kg 1compartment NA NA Human Human +DTXSID70873208 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70873208 TK.Half.Life NA 4.84 hours 1compartment NA NA Human Human +DTXSID70873208 Css NA 0.9226 mg/L 3compartmentss NA 50% Human Human +DTXSID70873208 Css NA 5.622 mg/L 3compartmentss NA 95% Human Human +DTXSID70873208 Css NA 0.7121 mg/L PBTK NA 50% Human Human +DTXSID70873208 Css NA 3.552 mg/L PBTK NA 95% Human Human +DTXSID70873208 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70873208 Fup 0.78 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70873208 Vd NA 0.5912 L/kg 1compartment NA NA Rat Human +DTXSID70873208 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70873208 TK.Half.Life NA 1.672 hours 1compartment NA NA Rat Human +DTXSID70873208 Css NA 0.02309 mg/L 3compartmentss NA 50% Rat Human +DTXSID70873208 Css NA 0.1795 mg/L 3compartmentss NA 95% Rat Human +DTXSID70873208 Css NA 0.01745 mg/L PBTK NA 50% Rat Human +DTXSID70873208 Css NA 0.1111 mg/L PBTK NA 95% Rat Human +DTXSID70873223 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70873223 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70873223 Vd NA 0.6406 L/kg 1compartment NA NA Human Human +DTXSID70873223 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70873223 TK.Half.Life NA 5.18 hours 1compartment NA NA Human Human +DTXSID70873223 Css NA 0.5466 mg/L 3compartmentss NA 50% Human Human +DTXSID70873223 Css NA 3.337 mg/L 3compartmentss NA 95% Human Human +DTXSID70873223 Css NA 0.4475 mg/L PBTK NA 50% Human Human +DTXSID70873223 Css NA 2.131 mg/L PBTK NA 95% Human Human +DTXSID70873223 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70873223 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70873223 Vd NA 0.6602 L/kg 1compartment NA NA Rat Human +DTXSID70873223 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70873223 TK.Half.Life NA 1.82 hours 1compartment NA NA Rat Human +DTXSID70873223 Css NA 0.00282 mg/L 3compartmentss NA 50% Rat Human +DTXSID70873223 Css NA 0.01804 mg/L 3compartmentss NA 95% Rat Human +DTXSID70873223 Css NA 0.002232 mg/L PBTK NA 50% Rat Human +DTXSID70873223 Css NA 0.01122 mg/L PBTK NA 95% Rat Human +DTXSID70873364 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70873364 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70873364 Vd NA 5.711 L/kg 1compartment NA NA Human Human +DTXSID70873364 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70873364 TK.Half.Life NA 7.752 hours 1compartment NA NA Human Human +DTXSID70873364 Css NA 0.05844 mg/L 3compartmentss NA 50% Human Human +DTXSID70873364 Css NA 0.6171 mg/L 3compartmentss NA 95% Human Human +DTXSID70873364 Css NA 0.0981 mg/L PBTK NA 50% Human Human +DTXSID70873364 Css NA 0.6444 mg/L PBTK NA 95% Human Human +DTXSID70873364 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70873364 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70873364 Vd NA 8.004 L/kg 1compartment NA NA Rat Human +DTXSID70873364 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70873364 TK.Half.Life NA 4.232 hours 1compartment NA NA Rat Human +DTXSID70873364 Css NA 0.00384 mg/L 3compartmentss NA 50% Rat Human +DTXSID70873364 Css NA 0.0504 mg/L 3compartmentss NA 95% Rat Human +DTXSID70873364 Css NA 0.008576 mg/L PBTK NA 50% Rat Human +DTXSID70873364 Css NA 0.04974 mg/L PBTK NA 95% Rat Human +DTXSID70873384 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70873384 Fup 0.91 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70873384 Vd NA 0.6496 L/kg 1compartment NA NA Human Human +DTXSID70873384 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70873384 TK.Half.Life NA 4.618 hours 1compartment NA NA Human Human +DTXSID70873384 Css NA 0.5134 mg/L 3compartmentss NA 50% Human Human +DTXSID70873384 Css NA 2.933 mg/L 3compartmentss NA 95% Human Human +DTXSID70873384 Css NA 0.4158 mg/L PBTK NA 50% Human Human +DTXSID70873384 Css NA 1.935 mg/L PBTK NA 95% Human Human +DTXSID70873384 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70873384 Fup 0.91 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70873384 Vd NA 0.6718 L/kg 1compartment NA NA Rat Human +DTXSID70873384 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70873384 TK.Half.Life NA 1.627 hours 1compartment NA NA Rat Human +DTXSID70873384 Css NA 0.002648 mg/L 3compartmentss NA 50% Rat Human +DTXSID70873384 Css NA 0.017 mg/L 3compartmentss NA 95% Rat Human +DTXSID70873384 Css NA 0.00208 mg/L PBTK NA 50% Rat Human +DTXSID70873384 Css NA 0.01068 mg/L PBTK NA 95% Rat Human +DTXSID70874013 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70874013 Fup 0.0155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70874013 Vd NA 118.3 L/kg 1compartment NA NA Human Human +DTXSID70874013 Days.Css NA 923 Days PBTK NA NA Human Human +DTXSID70874013 TK.Half.Life NA 3481 hours 1compartment NA NA Human Human +DTXSID70874013 Css NA 0.1594 mg/L 3compartmentss NA 50% Human Human +DTXSID70874013 Css NA 1.029 mg/L 3compartmentss NA 95% Human Human +DTXSID70874013 Css NA 2.362 mg/L PBTK NA 50% Human Human +DTXSID70874013 Css NA 13.63 mg/L PBTK NA 95% Human Human +DTXSID70874013 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70874013 Fup 0.0155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70874013 Vd NA 102.8 L/kg 1compartment NA NA Rat Human +DTXSID70874013 Days.Css NA 577 Days PBTK NA NA Rat Human +DTXSID70874013 TK.Half.Life NA 521.2 hours 1compartment NA NA Rat Human +DTXSID70874013 Css NA 0.01902 mg/L 3compartmentss NA 50% Rat Human +DTXSID70874013 Css NA 0.08745 mg/L 3compartmentss NA 95% Rat Human +DTXSID70874013 Css NA 0.3081 mg/L PBTK NA 50% Rat Human +DTXSID70874013 Css NA 1.471 mg/L PBTK NA 95% Rat Human +DTXSID70880659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880659 Fup 0.309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880659 Vd NA 1.767 L/kg 1compartment NA NA Human Human +DTXSID70880659 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70880659 TK.Half.Life NA 2.526 hours 1compartment NA NA Human Human +DTXSID70880659 Css NA 0.0821 mg/L 3compartmentss NA 50% Human Human +DTXSID70880659 Css NA 0.6062 mg/L 3compartmentss NA 95% Human Human +DTXSID70880659 Css NA 0.06253 mg/L PBTK NA 50% Human Human +DTXSID70880659 Css NA 0.4193 mg/L PBTK NA 95% Human Human +DTXSID70880659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880659 Fup 0.309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880659 Vd NA 1.406 L/kg 1compartment NA NA Rat Human +DTXSID70880659 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70880659 TK.Half.Life NA 0.9408 hours 1compartment NA NA Rat Human +DTXSID70880659 Css NA 0.01038 mg/L 3compartmentss NA 50% Rat Human +DTXSID70880659 Css NA 0.05654 mg/L 3compartmentss NA 95% Rat Human +DTXSID70880659 Css NA 0.007958 mg/L PBTK NA 50% Rat Human +DTXSID70880659 Css NA 0.03924 mg/L PBTK NA 95% Rat Human +DTXSID70880715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880715 Fup 0.0213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880715 Vd NA 6.991 L/kg 1compartment NA NA Human Human +DTXSID70880715 Days.Css NA 40 Days PBTK NA NA Human Human +DTXSID70880715 TK.Half.Life NA 209.2 hours 1compartment NA NA Human Human +DTXSID70880715 Css NA 2.486 mg/L 3compartmentss NA 50% Human Human +DTXSID70880715 Css NA 14.58 mg/L 3compartmentss NA 95% Human Human +DTXSID70880715 Css NA 2.362 mg/L PBTK NA 50% Human Human +DTXSID70880715 Css NA 13.52 mg/L PBTK NA 95% Human Human +DTXSID70880715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880715 Fup 0.0213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880715 Vd NA 5.418 L/kg 1compartment NA NA Rat Human +DTXSID70880715 Days.Css NA 24 Days PBTK NA NA Rat Human +DTXSID70880715 TK.Half.Life NA 28.51 hours 1compartment NA NA Rat Human +DTXSID70880715 Css NA 0.3167 mg/L 3compartmentss NA 50% Rat Human +DTXSID70880715 Css NA 1.503 mg/L 3compartmentss NA 95% Rat Human +DTXSID70880715 Css NA 0.3068 mg/L PBTK NA 50% Rat Human +DTXSID70880715 Css NA 1.483 mg/L PBTK NA 95% Rat Human +DTXSID70880811 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880811 Fup 0.0962 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880811 Vd NA 2.875 L/kg 1compartment NA NA Human Human +DTXSID70880811 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID70880811 TK.Half.Life NA 20.84 hours 1compartment NA NA Human Human +DTXSID70880811 Css NA 0.8177 mg/L 3compartmentss NA 50% Human Human +DTXSID70880811 Css NA 5.305 mg/L 3compartmentss NA 95% Human Human +DTXSID70880811 Css NA 0.5698 mg/L PBTK NA 50% Human Human +DTXSID70880811 Css NA 3.517 mg/L PBTK NA 95% Human Human +DTXSID70880811 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880811 Fup 0.0962 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880811 Vd NA 2.161 L/kg 1compartment NA NA Rat Human +DTXSID70880811 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID70880811 TK.Half.Life NA 4.063 hours 1compartment NA NA Rat Human +DTXSID70880811 Css NA 0.106 mg/L 3compartmentss NA 50% Rat Human +DTXSID70880811 Css NA 0.563 mg/L 3compartmentss NA 95% Rat Human +DTXSID70880811 Css NA 0.07297 mg/L PBTK NA 50% Rat Human +DTXSID70880811 Css NA 0.3781 mg/L PBTK NA 95% Rat Human +DTXSID70880836 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880836 Fup 0.0259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880836 Vd NA 4.005 L/kg 1compartment NA NA Human Human +DTXSID70880836 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID70880836 TK.Half.Life NA 120.3 hours 1compartment NA NA Human Human +DTXSID70880836 Css NA 1.732 mg/L 3compartmentss NA 50% Human Human +DTXSID70880836 Css NA 11.15 mg/L 3compartmentss NA 95% Human Human +DTXSID70880836 Css NA 1.294 mg/L PBTK NA 50% Human Human +DTXSID70880836 Css NA 8.28 mg/L PBTK NA 95% Human Human +DTXSID70880836 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880836 Fup 0.0259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880836 Vd NA 3.03 L/kg 1compartment NA NA Rat Human +DTXSID70880836 Days.Css NA 12 Days PBTK NA NA Rat Human +DTXSID70880836 TK.Half.Life NA 16.09 hours 1compartment NA NA Rat Human +DTXSID70880836 Css NA 0.01869 mg/L 3compartmentss NA 50% Rat Human +DTXSID70880836 Css NA 0.1157 mg/L 3compartmentss NA 95% Rat Human +DTXSID70880836 Css NA 0.01349 mg/L PBTK NA 50% Rat Human +DTXSID70880836 Css NA 0.08324 mg/L PBTK NA 95% Rat Human +DTXSID70880856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880856 Fup 0.0832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880856 Vd NA 2.967 L/kg 1compartment NA NA Human Human +DTXSID70880856 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID70880856 TK.Half.Life NA 29.15 hours 1compartment NA NA Human Human +DTXSID70880856 Css NA 1.132 mg/L 3compartmentss NA 50% Human Human +DTXSID70880856 Css NA 7.335 mg/L 3compartmentss NA 95% Human Human +DTXSID70880856 Css NA 0.7852 mg/L PBTK NA 50% Human Human +DTXSID70880856 Css NA 4.963 mg/L PBTK NA 95% Human Human +DTXSID70880856 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880856 Fup 0.0832 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880856 Vd NA 2.227 L/kg 1compartment NA NA Rat Human +DTXSID70880856 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID70880856 TK.Half.Life NA 5.067 hours 1compartment NA NA Rat Human +DTXSID70880856 Css NA 0.1478 mg/L 3compartmentss NA 50% Rat Human +DTXSID70880856 Css NA 0.7559 mg/L 3compartmentss NA 95% Rat Human +DTXSID70880856 Css NA 0.1012 mg/L PBTK NA 50% Rat Human +DTXSID70880856 Css NA 0.5086 mg/L PBTK NA 95% Rat Human +DTXSID70880912 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880912 Fup 0.529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880912 Vd NA 0.648 L/kg 1compartment NA NA Human Human +DTXSID70880912 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70880912 TK.Half.Life NA 7.957 hours 1compartment NA NA Human Human +DTXSID70880912 Css NA 1.348 mg/L 3compartmentss NA 50% Human Human +DTXSID70880912 Css NA 7.683 mg/L 3compartmentss NA 95% Human Human +DTXSID70880912 Css NA 1.045 mg/L PBTK NA 50% Human Human +DTXSID70880912 Css NA 4.853 mg/L PBTK NA 95% Human Human +DTXSID70880912 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880912 Fup 0.529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880912 Vd NA 0.6538 L/kg 1compartment NA NA Rat Human +DTXSID70880912 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70880912 TK.Half.Life NA 2.728 hours 1compartment NA NA Rat Human +DTXSID70880912 Css NA 0.08306 mg/L 3compartmentss NA 50% Rat Human +DTXSID70880912 Css NA 0.4354 mg/L 3compartmentss NA 95% Rat Human +DTXSID70880912 Css NA 0.06415 mg/L PBTK NA 50% Rat Human +DTXSID70880912 Css NA 0.2659 mg/L PBTK NA 95% Rat Human +DTXSID70880917 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880917 Fup 0.00718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880917 Vd NA 3.061 L/kg 1compartment NA NA Human Human +DTXSID70880917 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID70880917 TK.Half.Life NA 87.9 hours 1compartment NA NA Human Human +DTXSID70880917 Css NA 3.496 mg/L 3compartmentss NA 50% Human Human +DTXSID70880917 Css NA 22.48 mg/L 3compartmentss NA 95% Human Human +DTXSID70880917 Css NA 2.401 mg/L PBTK NA 50% Human Human +DTXSID70880917 Css NA 15.21 mg/L PBTK NA 95% Human Human +DTXSID70880917 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880917 Fup 0.00718 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880917 Vd NA 2.293 L/kg 1compartment NA NA Rat Human +DTXSID70880917 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID70880917 TK.Half.Life NA 12.78 hours 1compartment NA NA Rat Human +DTXSID70880917 Css NA 0.4579 mg/L 3compartmentss NA 50% Rat Human +DTXSID70880917 Css NA 2.346 mg/L 3compartmentss NA 95% Rat Human +DTXSID70880917 Css NA 0.3117 mg/L PBTK NA 50% Rat Human +DTXSID70880917 Css NA 1.595 mg/L PBTK NA 95% Rat Human +DTXSID70880937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880937 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70880937 Vd NA 2.94 L/kg 1compartment NA NA Human Human +DTXSID70880937 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID70880937 TK.Half.Life NA 44.86 hours 1compartment NA NA Human Human +DTXSID70880937 Css NA 1.89 mg/L 3compartmentss NA 50% Human Human +DTXSID70880937 Css NA 13.29 mg/L 3compartmentss NA 95% Human Human +DTXSID70880937 Css NA 1.294 mg/L PBTK NA 50% Human Human +DTXSID70880937 Css NA 8.657 mg/L PBTK NA 95% Human Human +DTXSID70880937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880937 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70880937 Vd NA 2.202 L/kg 1compartment NA NA Rat Human +DTXSID70880937 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID70880937 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human +DTXSID70880937 Css NA 0.2454 mg/L 3compartmentss NA 50% Rat Human +DTXSID70880937 Css NA 1.39 mg/L 3compartmentss NA 95% Rat Human +DTXSID70880937 Css NA 0.1657 mg/L PBTK NA 50% Rat Human +DTXSID70880937 Css NA 0.919 mg/L PBTK NA 95% Rat Human +DTXSID70881202 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70881202 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70881202 Vd NA 2.903 L/kg 1compartment NA NA Human Human +DTXSID70881202 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70881202 TK.Half.Life NA 9.408 hours 1compartment NA NA Human Human +DTXSID70881202 Css NA 0.2876 mg/L 3compartmentss NA 50% Human Human +DTXSID70881202 Css NA 1.821 mg/L 3compartmentss NA 95% Human Human +DTXSID70881202 Css NA 0.2099 mg/L PBTK NA 50% Human Human +DTXSID70881202 Css NA 1.293 mg/L PBTK NA 95% Human Human +DTXSID70881202 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70881202 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70881202 Vd NA 2.206 L/kg 1compartment NA NA Rat Human +DTXSID70881202 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70881202 TK.Half.Life NA 2.036 hours 1compartment NA NA Rat Human +DTXSID70881202 Css NA 0.03652 mg/L 3compartmentss NA 50% Rat Human +DTXSID70881202 Css NA 0.1804 mg/L 3compartmentss NA 95% Rat Human +DTXSID70881202 Css NA 0.02661 mg/L PBTK NA 50% Rat Human +DTXSID70881202 Css NA 0.1293 mg/L PBTK NA 95% Rat Human +DTXSID70881242 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70881242 Fup 0.023 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70881242 Vd NA 32.42 L/kg 1compartment NA NA Human Human +DTXSID70881242 Days.Css NA 61 Days PBTK NA NA Human Human +DTXSID70881242 TK.Half.Life NA 303.2 hours 1compartment NA NA Human Human +DTXSID70881242 Css NA 0.1614 mg/L 3compartmentss NA 50% Human Human +DTXSID70881242 Css NA 2.229 mg/L 3compartmentss NA 95% Human Human +DTXSID70881242 Css NA 0.5094 mg/L PBTK NA 50% Human Human +DTXSID70881242 Css NA 4.167 mg/L PBTK NA 95% Human Human +DTXSID70881242 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70881242 Fup 0.023 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70881242 Vd NA 26.89 L/kg 1compartment NA NA Rat Human +DTXSID70881242 Days.Css NA 39 Days PBTK NA NA Rat Human +DTXSID70881242 TK.Half.Life NA 97.49 hours 1compartment NA NA Rat Human +DTXSID70881242 Css NA 0.001584 mg/L 3compartmentss NA 50% Rat Human +DTXSID70881242 Css NA 0.0207 mg/L 3compartmentss NA 95% Rat Human +DTXSID70881242 Css NA 0.00527 mg/L PBTK NA 50% Rat Human +DTXSID70881242 Css NA 0.03806 mg/L PBTK NA 95% Rat Human +DTXSID70891503 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70891503 Fup 0.13 NA NA https://doi.org/10.1002/bdd.711 NA Human Human +DTXSID70891503 Vd NA 0.2803 L/kg 1compartment NA NA Human Human +DTXSID70891503 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID70891503 TK.Half.Life NA 13.95 hours 1compartment NA NA Human Human +DTXSID70891503 Css NA 4.476 mg/L 3compartmentss NA 50% Human Human +DTXSID70891503 Css NA 21.53 mg/L 3compartmentss NA 95% Human Human +DTXSID70891503 Css NA 2.506 mg/L PBTK NA 50% Human Human +DTXSID70891503 Css NA 12.06 mg/L PBTK NA 95% Human Human +DTXSID70891503 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70891503 Fup 0.13 NA NA https://doi.org/10.1002/bdd.711 NA Rat Human +DTXSID70891503 Vd NA 0.2873 L/kg 1compartment NA NA Rat Human +DTXSID70891503 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70891503 TK.Half.Life NA 4.871 hours 1compartment NA NA Rat Human +DTXSID70891503 Css NA 0.02287 mg/L 3compartmentss NA 50% Rat Human +DTXSID70891503 Css NA 0.1057 mg/L 3compartmentss NA 95% Rat Human +DTXSID70891503 Css NA 0.01283 mg/L PBTK NA 50% Rat Human +DTXSID70891503 Css NA 0.05957 mg/L PBTK NA 95% Rat Human +DTXSID70893769 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70893769 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70893769 Vd NA 1.726 L/kg 1compartment NA NA Human Human +DTXSID70893769 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70893769 TK.Half.Life NA 1.819 hours 1compartment NA NA Human Human +DTXSID70893769 Css NA 0.07209 mg/L 3compartmentss NA 50% Human Human +DTXSID70893769 Css NA 0.6812 mg/L 3compartmentss NA 95% Human Human +DTXSID70893769 Css NA 0.06961 mg/L PBTK NA 50% Human Human +DTXSID70893769 Css NA 0.4968 mg/L PBTK NA 95% Human Human +DTXSID70893769 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70893769 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70893769 Vd NA 1.718 L/kg 1compartment NA NA Rat Human +DTXSID70893769 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70893769 TK.Half.Life NA 0.9713 hours 1compartment NA NA Rat Human +DTXSID70893769 Css NA 0.007753 mg/L 3compartmentss NA 50% Rat Human +DTXSID70893769 Css NA 0.0563 mg/L 3compartmentss NA 95% Rat Human +DTXSID70893769 Css NA 0.007849 mg/L PBTK NA 50% Rat Human +DTXSID70893769 Css NA 0.04 mg/L PBTK NA 95% Rat Human +DTXSID70904521 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70904521 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70904521 Vd NA 0.4102 L/kg 1compartment NA NA Human Human +DTXSID70904521 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID70904521 TK.Half.Life NA 19.51 hours 1compartment NA NA Human Human +DTXSID70904521 Css NA 3.826 mg/L 3compartmentss NA 50% Human Human +DTXSID70904521 Css NA 18.81 mg/L 3compartmentss NA 95% Human Human +DTXSID70904521 Css NA 2.434 mg/L PBTK NA 50% Human Human +DTXSID70904521 Css NA 11.29 mg/L PBTK NA 95% Human Human +DTXSID70904521 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70904521 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70904521 Vd NA 0.3831 L/kg 1compartment NA NA Rat Human +DTXSID70904521 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70904521 TK.Half.Life NA 6.172 hours 1compartment NA NA Rat Human +DTXSID70904521 Css NA 0.02094 mg/L 3compartmentss NA 50% Rat Human +DTXSID70904521 Css NA 0.1015 mg/L 3compartmentss NA 95% Rat Human +DTXSID70904521 Css NA 0.01254 mg/L PBTK NA 50% Rat Human +DTXSID70904521 Css NA 0.05711 mg/L PBTK NA 95% Rat Human +DTXSID70931418 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID70931418 Fup 0.36 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID70931418 Vd NA 0.5991 L/kg 1compartment NA NA Human Human +DTXSID70931418 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID70931418 TK.Half.Life NA 1.299 hours 1compartment NA NA Human Human +DTXSID70931418 Css NA 0.02727 mg/L 3compartmentss NA 50% Human Human +DTXSID70931418 Css NA 0.2314 mg/L 3compartmentss NA 95% Human Human +DTXSID70931418 Css NA 0.02128 mg/L PBTK NA 50% Human Human +DTXSID70931418 Css NA 0.1612 mg/L PBTK NA 95% Human Human +DTXSID70931418 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID70931418 Fup 0.36 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID70931418 Vd NA 0.5895 L/kg 1compartment NA NA Rat Human +DTXSID70931418 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID70931418 TK.Half.Life NA 0.7241 hours 1compartment NA NA Rat Human +DTXSID70931418 Css NA 0.0002006 mg/L 3compartmentss NA 50% Rat Human +DTXSID70931418 Css NA 0.001271 mg/L 3compartmentss NA 95% Rat Human +DTXSID70931418 Css NA 0.0001508 mg/L PBTK NA 50% Rat Human +DTXSID70931418 Css NA 0.0008194 mg/L PBTK NA 95% Rat Human +DTXSID801001609 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801001609 Fup 0.0877 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801001609 Vd NA 2.747 L/kg 1compartment NA NA Human Human +DTXSID801001609 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID801001609 TK.Half.Life NA 17.23 hours 1compartment NA NA Human Human +DTXSID801001609 Css NA 0.7233 mg/L 3compartmentss NA 50% Human Human +DTXSID801001609 Css NA 4.653 mg/L 3compartmentss NA 95% Human Human +DTXSID801001609 Css NA 0.4974 mg/L PBTK NA 50% Human Human +DTXSID801001609 Css NA 3.109 mg/L PBTK NA 95% Human Human +DTXSID801001609 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801001609 Fup 0.0877 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801001609 Vd NA 2.064 L/kg 1compartment NA NA Rat Human +DTXSID801001609 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID801001609 TK.Half.Life NA 3.757 hours 1compartment NA NA Rat Human +DTXSID801001609 Css NA 0.0908 mg/L 3compartmentss NA 50% Rat Human +DTXSID801001609 Css NA 0.4954 mg/L 3compartmentss NA 95% Rat Human +DTXSID801001609 Css NA 0.06189 mg/L PBTK NA 50% Rat Human +DTXSID801001609 Css NA 0.3313 mg/L PBTK NA 95% Rat Human +DTXSID801005118 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801005118 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID801005118 Vd NA 0.4149 L/kg 1compartment NA NA Human Human +DTXSID801005118 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID801005118 TK.Half.Life NA 3.729 hours 1compartment NA NA Human Human +DTXSID801005118 Css NA 0.6504 mg/L 3compartmentss NA 50% Human Human +DTXSID801005118 Css NA 4.126 mg/L 3compartmentss NA 95% Human Human +DTXSID801005118 Css NA 0.4719 mg/L PBTK NA 50% Human Human +DTXSID801005118 Css NA 2.542 mg/L PBTK NA 95% Human Human +DTXSID801005118 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801005118 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID801005118 Vd NA 0.4353 L/kg 1compartment NA NA Rat Human +DTXSID801005118 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID801005118 TK.Half.Life NA 1.333 hours 1compartment NA NA Rat Human +DTXSID801005118 Css NA 0.003474 mg/L 3compartmentss NA 50% Rat Human +DTXSID801005118 Css NA 0.02233 mg/L 3compartmentss NA 95% Rat Human +DTXSID801005118 Css NA 0.002396 mg/L PBTK NA 50% Rat Human +DTXSID801005118 Css NA 0.01306 mg/L PBTK NA 95% Rat Human +DTXSID801025708 Clint 28 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID801025708 Fup 0.008 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID801025708 Vd NA 0.2011 L/kg 1compartment NA NA Human Human +DTXSID801025708 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID801025708 TK.Half.Life NA 3.524 hours 1compartment NA NA Human Human +DTXSID801025708 Css NA 3.101 mg/L 3compartmentss NA 50% Human Human +DTXSID801025708 Css NA 32.16 mg/L 3compartmentss NA 95% Human Human +DTXSID801025708 Css NA 1.818 mg/L PBTK NA 50% Human Human +DTXSID801025708 Css NA 18.8 mg/L PBTK NA 95% Human Human +DTXSID801025708 Clint 28 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID801025708 Fup 0.008 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID801025708 Vd NA 0.1877 L/kg 1compartment NA NA Rat Human +DTXSID801025708 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID801025708 TK.Half.Life NA 2.212 hours 1compartment NA NA Rat Human +DTXSID801025708 Css NA 0.4162 mg/L 3compartmentss NA 50% Rat Human +DTXSID801025708 Css NA 3.366 mg/L 3compartmentss NA 95% Rat Human +DTXSID801025708 Css NA 0.2344 mg/L PBTK NA 50% Rat Human +DTXSID801025708 Css NA 1.888 mg/L PBTK NA 95% Rat Human +DTXSID801026049 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801026049 Fup 0.0645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801026049 Vd NA 2.013 L/kg 1compartment NA NA Human Human +DTXSID801026049 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID801026049 TK.Half.Life NA 26.44 hours 1compartment NA NA Human Human +DTXSID801026049 Css NA 1.796 mg/L 3compartmentss NA 50% Human Human +DTXSID801026049 Css NA 11.07 mg/L 3compartmentss NA 95% Human Human +DTXSID801026049 Css NA 1.188 mg/L PBTK NA 50% Human Human +DTXSID801026049 Css NA 6.976 mg/L PBTK NA 95% Human Human +DTXSID801026049 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801026049 Fup 0.0645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801026049 Vd NA 1.513 L/kg 1compartment NA NA Rat Human +DTXSID801026049 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID801026049 TK.Half.Life NA 8.265 hours 1compartment NA NA Rat Human +DTXSID801026049 Css NA 0.2255 mg/L 3compartmentss NA 50% Rat Human +DTXSID801026049 Css NA 0.992 mg/L 3compartmentss NA 95% Rat Human +DTXSID801026049 Css NA 0.1468 mg/L PBTK NA 50% Rat Human +DTXSID801026049 Css NA 0.6101 mg/L PBTK NA 95% Rat Human +DTXSID801126136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801126136 Fup 0.0968 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801126136 Vd NA 1.494 L/kg 1compartment NA NA Human Human +DTXSID801126136 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID801126136 TK.Half.Life NA 4.346 hours 1compartment NA NA Human Human +DTXSID801126136 Css NA 0.3011 mg/L 3compartmentss NA 50% Human Human +DTXSID801126136 Css NA 2.408 mg/L 3compartmentss NA 95% Human Human +DTXSID801126136 Css NA 0.1993 mg/L PBTK NA 50% Human Human +DTXSID801126136 Css NA 1.524 mg/L PBTK NA 95% Human Human +DTXSID801126136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801126136 Fup 0.0968 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801126136 Vd NA 1.143 L/kg 1compartment NA NA Rat Human +DTXSID801126136 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID801126136 TK.Half.Life NA 1.686 hours 1compartment NA NA Rat Human +DTXSID801126136 Css NA 0.0264 mg/L 3compartmentss NA 50% Rat Human +DTXSID801126136 Css NA 0.1763 mg/L 3compartmentss NA 95% Rat Human +DTXSID801126136 Css NA 0.01714 mg/L PBTK NA 50% Rat Human +DTXSID801126136 Css NA 0.107 mg/L PBTK NA 95% Rat Human +DTXSID801135422 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801135422 Fup 0.06 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801135422 Vd NA 1.066 L/kg 1compartment NA NA Human Human +DTXSID801135422 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID801135422 TK.Half.Life NA 11.21 hours 1compartment NA NA Human Human +DTXSID801135422 Css NA 1.602 mg/L 3compartmentss NA 50% Human Human +DTXSID801135422 Css NA 11.28 mg/L 3compartmentss NA 95% Human Human +DTXSID801135422 Css NA 1.008 mg/L PBTK NA 50% Human Human +DTXSID801135422 Css NA 6.737 mg/L PBTK NA 95% Human Human +DTXSID801135422 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801135422 Fup 0.06 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801135422 Vd NA 0.8161 L/kg 1compartment NA NA Rat Human +DTXSID801135422 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID801135422 TK.Half.Life NA 4.797 hours 1compartment NA NA Rat Human +DTXSID801135422 Css NA 0.1977 mg/L 3compartmentss NA 50% Rat Human +DTXSID801135422 Css NA 1.023 mg/L 3compartmentss NA 95% Rat Human +DTXSID801135422 Css NA 0.1214 mg/L PBTK NA 50% Rat Human +DTXSID801135422 Css NA 0.6003 mg/L PBTK NA 95% Rat Human +DTXSID801317967 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801317967 Fup 0.0762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID801317967 Vd NA 3.612 L/kg 1compartment NA NA Human Human +DTXSID801317967 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID801317967 TK.Half.Life NA 3.158 hours 1compartment NA NA Human Human +DTXSID801317967 Css NA 0.03647 mg/L 3compartmentss NA 50% Human Human +DTXSID801317967 Css NA 0.3555 mg/L 3compartmentss NA 95% Human Human +DTXSID801317967 Css NA 0.03667 mg/L PBTK NA 50% Human Human +DTXSID801317967 Css NA 0.2938 mg/L PBTK NA 95% Human Human +DTXSID801317967 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801317967 Fup 0.0762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID801317967 Vd NA 3.436 L/kg 1compartment NA NA Rat Human +DTXSID801317967 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID801317967 TK.Half.Life NA 1.472 hours 1compartment NA NA Rat Human +DTXSID801317967 Css NA 0.004498 mg/L 3compartmentss NA 50% Rat Human +DTXSID801317967 Css NA 0.03506 mg/L 3compartmentss NA 95% Rat Human +DTXSID801317967 Css NA 0.004678 mg/L PBTK NA 50% Rat Human +DTXSID801317967 Css NA 0.03026 mg/L PBTK NA 95% Rat Human +DTXSID801339341 Clint NA 128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID801339341 Fup NA 0.0229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID801339341 Vd NA 1.381 L/kg 1compartment NA NA Human Human +DTXSID801339341 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID801339341 TK.Half.Life NA 2.994 hours 1compartment NA NA Human Human +DTXSID801339341 Css NA 0.1811 mg/L 3compartmentss NA 50% Human Human +DTXSID801339341 Css NA 1.946 mg/L 3compartmentss NA 95% Human Human +DTXSID801339341 Css NA 0.1129 mg/L PBTK NA 50% Human Human +DTXSID801339341 Css NA 1.151 mg/L PBTK NA 95% Human Human +DTXSID801339341 Clint NA 128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID801339341 Fup NA 0.0229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID801339341 Vd NA 1.023 L/kg 1compartment NA NA Rat Human +DTXSID801339341 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID801339341 TK.Half.Life NA 1.123 hours 1compartment NA NA Rat Human +DTXSID801339341 Css NA 0.007178 mg/L 3compartmentss NA 50% Rat Human +DTXSID801339341 Css NA 0.08384 mg/L 3compartmentss NA 95% Rat Human +DTXSID801339341 Css NA 0.004268 mg/L PBTK NA 50% Rat Human +DTXSID801339341 Css NA 0.04812 mg/L PBTK NA 95% Rat Human +DTXSID80151807 Clint 25.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80151807 Fup 0.0177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80151807 Vd NA 2.986 L/kg 1compartment NA NA Human Human +DTXSID80151807 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID80151807 TK.Half.Life NA 53.65 hours 1compartment NA NA Human Human +DTXSID80151807 Css NA 2.245 mg/L 3compartmentss NA 50% Human Human +DTXSID80151807 Css NA 14.78 mg/L 3compartmentss NA 95% Human Human +DTXSID80151807 Css NA 1.53 mg/L PBTK NA 50% Human Human +DTXSID80151807 Css NA 9.852 mg/L PBTK NA 95% Human Human +DTXSID80151807 Clint 25.12 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80151807 Fup 0.0177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80151807 Vd NA 2.236 L/kg 1compartment NA NA Rat Human +DTXSID80151807 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID80151807 TK.Half.Life NA 8.697 hours 1compartment NA NA Rat Human +DTXSID80151807 Css NA 0.289 mg/L 3compartmentss NA 50% Rat Human +DTXSID80151807 Css NA 1.696 mg/L 3compartmentss NA 95% Rat Human +DTXSID80151807 Css NA 0.1957 mg/L PBTK NA 50% Rat Human +DTXSID80151807 Css NA 1.102 mg/L PBTK NA 95% Rat Human +DTXSID80155022 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80155022 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80155022 Vd NA 3.857 L/kg 1compartment NA NA Human Human +DTXSID80155022 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80155022 TK.Half.Life NA 8.151 hours 1compartment NA NA Human Human +DTXSID80155022 Css NA 0.1176 mg/L 3compartmentss NA 50% Human Human +DTXSID80155022 Css NA 0.9337 mg/L 3compartmentss NA 95% Human Human +DTXSID80155022 Css NA 0.1482 mg/L PBTK NA 50% Human Human +DTXSID80155022 Css NA 0.8869 mg/L PBTK NA 95% Human Human +DTXSID80155022 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80155022 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80155022 Vd NA 3.877 L/kg 1compartment NA NA Rat Human +DTXSID80155022 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80155022 TK.Half.Life NA 4.899 hours 1compartment NA NA Rat Human +DTXSID80155022 Css NA 0.01384 mg/L 3compartmentss NA 50% Rat Human +DTXSID80155022 Css NA 0.08153 mg/L 3compartmentss NA 95% Rat Human +DTXSID80155022 Css NA 0.01813 mg/L PBTK NA 50% Rat Human +DTXSID80155022 Css NA 0.077 mg/L PBTK NA 95% Rat Human +DTXSID80161224 Clint 33 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID80161224 Fup 0.273 NA NA Williamson 2020 NA Human Human +DTXSID80161224 Vd NA 3.084 L/kg 1compartment NA NA Human Human +DTXSID80161224 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID80161224 TK.Half.Life NA 17.02 hours 1compartment NA NA Human Human +DTXSID80161224 Css NA 0.4818 mg/L 3compartmentss NA 50% Human Human +DTXSID80161224 Css NA 3.249 mg/L 3compartmentss NA 95% Human Human +DTXSID80161224 Css NA 0.3409 mg/L PBTK NA 50% Human Human +DTXSID80161224 Css NA 2.227 mg/L PBTK NA 95% Human Human +DTXSID80161224 Clint 33 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID80161224 Fup 0.273 NA NA Williamson 2020 NA Rat Human +DTXSID80161224 Vd NA 2.322 L/kg 1compartment NA NA Rat Human +DTXSID80161224 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80161224 TK.Half.Life NA 2.84 hours 1compartment NA NA Rat Human +DTXSID80161224 Css NA 0.01811 mg/L 3compartmentss NA 50% Rat Human +DTXSID80161224 Css NA 0.1325 mg/L 3compartmentss NA 95% Rat Human +DTXSID80161224 Css NA 0.01244 mg/L PBTK NA 50% Rat Human +DTXSID80161224 Css NA 0.08733 mg/L PBTK NA 95% Rat Human +DTXSID80162130 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80162130 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80162130 Vd NA 1.266 L/kg 1compartment NA NA Human Human +DTXSID80162130 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID80162130 TK.Half.Life NA 13.14 hours 1compartment NA NA Human Human +DTXSID80162130 Css NA 1.443 mg/L 3compartmentss NA 50% Human Human +DTXSID80162130 Css NA 13.09 mg/L 3compartmentss NA 95% Human Human +DTXSID80162130 Css NA 0.8871 mg/L PBTK NA 50% Human Human +DTXSID80162130 Css NA 7.764 mg/L PBTK NA 95% Human Human +DTXSID80162130 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80162130 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80162130 Vd NA 0.9371 L/kg 1compartment NA NA Rat Human +DTXSID80162130 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80162130 TK.Half.Life NA 5.398 hours 1compartment NA NA Rat Human +DTXSID80162130 Css NA 0.0585 mg/L 3compartmentss NA 50% Rat Human +DTXSID80162130 Css NA 0.5997 mg/L 3compartmentss NA 95% Rat Human +DTXSID80162130 Css NA 0.0345 mg/L PBTK NA 50% Rat Human +DTXSID80162130 Css NA 0.3404 mg/L PBTK NA 95% Rat Human +DTXSID80162857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80162857 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80162857 Vd NA 0.8862 L/kg 1compartment NA NA Human Human +DTXSID80162857 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80162857 TK.Half.Life NA 1.643 hours 1compartment NA NA Human Human +DTXSID80162857 Css NA 0.1424 mg/L 3compartmentss NA 50% Human Human +DTXSID80162857 Css NA 1.104 mg/L 3compartmentss NA 95% Human Human +DTXSID80162857 Css NA 0.09756 mg/L PBTK NA 50% Human Human +DTXSID80162857 Css NA 0.7138 mg/L PBTK NA 95% Human Human +DTXSID80162857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80162857 Fup 0.162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80162857 Vd NA 0.792 L/kg 1compartment NA NA Rat Human +DTXSID80162857 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80162857 TK.Half.Life NA 0.8188 hours 1compartment NA NA Rat Human +DTXSID80162857 Css NA 0.01826 mg/L 3compartmentss NA 50% Rat Human +DTXSID80162857 Css NA 0.1128 mg/L 3compartmentss NA 95% Rat Human +DTXSID80162857 Css NA 0.01233 mg/L PBTK NA 50% Rat Human +DTXSID80162857 Css NA 0.06875 mg/L PBTK NA 95% Rat Human +DTXSID80164336 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80164336 Fup 0.0019 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80164336 Vd NA 0.1758 L/kg 1compartment NA NA Human Human +DTXSID80164336 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID80164336 TK.Half.Life NA 16.06 hours 1compartment NA NA Human Human +DTXSID80164336 Css NA 15.16 mg/L 3compartmentss NA 50% Human Human +DTXSID80164336 Css NA 143 mg/L 3compartmentss NA 95% Human Human +DTXSID80164336 Css NA 8.832 mg/L PBTK NA 50% Human Human +DTXSID80164336 Css NA 82.06 mg/L PBTK NA 95% Human Human +DTXSID80164336 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80164336 Fup 0.0019 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80164336 Vd NA 0.1709 L/kg 1compartment NA NA Rat Human +DTXSID80164336 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID80164336 TK.Half.Life NA 10.61 hours 1compartment NA NA Rat Human +DTXSID80164336 Css NA 0.7438 mg/L 3compartmentss NA 50% Rat Human +DTXSID80164336 Css NA 7.678 mg/L 3compartmentss NA 95% Rat Human +DTXSID80164336 Css NA 0.4106 mg/L PBTK NA 50% Rat Human +DTXSID80164336 Css NA 4.268 mg/L PBTK NA 95% Rat Human +DTXSID80170497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80170497 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80170497 Vd NA 2.785 L/kg 1compartment NA NA Human Human +DTXSID80170497 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID80170497 TK.Half.Life NA 39.01 hours 1compartment NA NA Human Human +DTXSID80170497 Css NA 1.828 mg/L 3compartmentss NA 50% Human Human +DTXSID80170497 Css NA 12.63 mg/L 3compartmentss NA 95% Human Human +DTXSID80170497 Css NA 1.236 mg/L PBTK NA 50% Human Human +DTXSID80170497 Css NA 8.141 mg/L PBTK NA 95% Human Human +DTXSID80170497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80170497 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80170497 Vd NA 2.083 L/kg 1compartment NA NA Rat Human +DTXSID80170497 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID80170497 TK.Half.Life NA 7.792 hours 1compartment NA NA Rat Human +DTXSID80170497 Css NA 0.2373 mg/L 3compartmentss NA 50% Rat Human +DTXSID80170497 Css NA 1.378 mg/L 3compartmentss NA 95% Rat Human +DTXSID80170497 Css NA 0.1582 mg/L PBTK NA 50% Rat Human +DTXSID80170497 Css NA 0.8946 mg/L PBTK NA 95% Rat Human +DTXSID80173105 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80173105 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80173105 Vd NA 1.842 L/kg 1compartment NA NA Human Human +DTXSID80173105 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80173105 TK.Half.Life NA 3.533 hours 1compartment NA NA Human Human +DTXSID80173105 Css NA 0.1397 mg/L 3compartmentss NA 50% Human Human +DTXSID80173105 Css NA 0.9193 mg/L 3compartmentss NA 95% Human Human +DTXSID80173105 Css NA 0.1013 mg/L PBTK NA 50% Human Human +DTXSID80173105 Css NA 0.6199 mg/L PBTK NA 95% Human Human +DTXSID80173105 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80173105 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80173105 Vd NA 1.43 L/kg 1compartment NA NA Rat Human +DTXSID80173105 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80173105 TK.Half.Life NA 1.266 hours 1compartment NA NA Rat Human +DTXSID80173105 Css NA 0.01759 mg/L 3compartmentss NA 50% Rat Human +DTXSID80173105 Css NA 0.08839 mg/L 3compartmentss NA 95% Rat Human +DTXSID80173105 Css NA 0.0127 mg/L PBTK NA 50% Rat Human +DTXSID80173105 Css NA 0.0607 mg/L PBTK NA 95% Rat Human +DTXSID80175220 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID80175220 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80175220 Vd NA 4.961 L/kg 1compartment NA NA Human Human +DTXSID80175220 Days.Css NA 150 Days PBTK NA NA Human Human +DTXSID80175220 TK.Half.Life NA 633.6 hours 1compartment NA NA Human Human +DTXSID80175220 Css NA 12.84 mg/L 3compartmentss NA 50% Human Human +DTXSID80175220 Css NA 76.49 mg/L 3compartmentss NA 95% Human Human +DTXSID80175220 Css NA 10.4 mg/L PBTK NA 50% Human Human +DTXSID80175220 Css NA 60.15 mg/L PBTK NA 95% Human Human +DTXSID80175220 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID80175220 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80175220 Vd NA 3.788 L/kg 1compartment NA NA Rat Human +DTXSID80175220 Days.Css NA 84 Days PBTK NA NA Rat Human +DTXSID80175220 TK.Half.Life NA 85.22 hours 1compartment NA NA Rat Human +DTXSID80175220 Css NA 1.672 mg/L 3compartmentss NA 50% Rat Human +DTXSID80175220 Css NA 8.048 mg/L 3compartmentss NA 95% Rat Human +DTXSID80175220 Css NA 1.354 mg/L PBTK NA 50% Rat Human +DTXSID80175220 Css NA 6.666 mg/L PBTK NA 95% Rat Human +DTXSID80179460 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID80179460 Fup 0.023 NA NA Williamson 2020 NA Human Human +DTXSID80179460 Vd NA 2.014 L/kg 1compartment NA NA Human Human +DTXSID80179460 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID80179460 TK.Half.Life NA 72.18 hours 1compartment NA NA Human Human +DTXSID80179460 Css NA 4.802 mg/L 3compartmentss NA 50% Human Human +DTXSID80179460 Css NA 34.97 mg/L 3compartmentss NA 95% Human Human +DTXSID80179460 Css NA 3.109 mg/L PBTK NA 50% Human Human +DTXSID80179460 Css NA 21.61 mg/L PBTK NA 95% Human Human +DTXSID80179460 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID80179460 Fup 0.023 NA NA Williamson 2020 NA Rat Human +DTXSID80179460 Vd NA 1.499 L/kg 1compartment NA NA Rat Human +DTXSID80179460 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID80179460 TK.Half.Life NA 22.01 hours 1compartment NA NA Rat Human +DTXSID80179460 Css NA 0.1756 mg/L 3compartmentss NA 50% Rat Human +DTXSID80179460 Css NA 1.444 mg/L 3compartmentss NA 95% Rat Human +DTXSID80179460 Css NA 0.1092 mg/L PBTK NA 50% Rat Human +DTXSID80179460 Css NA 0.8481 mg/L PBTK NA 95% Rat Human +DTXSID80190615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80190615 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80190615 Vd NA 1.287 L/kg 1compartment NA NA Human Human +DTXSID80190615 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80190615 TK.Half.Life NA 1.847 hours 1compartment NA NA Human Human +DTXSID80190615 Css NA 0.08317 mg/L 3compartmentss NA 50% Human Human +DTXSID80190615 Css NA 0.5672 mg/L 3compartmentss NA 95% Human Human +DTXSID80190615 Css NA 0.0612 mg/L PBTK NA 50% Human Human +DTXSID80190615 Css NA 0.3887 mg/L PBTK NA 95% Human Human +DTXSID80190615 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80190615 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80190615 Vd NA 1.824 L/kg 1compartment NA NA Rat Human +DTXSID80190615 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80190615 TK.Half.Life NA 0.6639 hours 1compartment NA NA Rat Human +DTXSID80190615 Css NA 0.0036 mg/L 3compartmentss NA 50% Rat Human +DTXSID80190615 Css NA 0.02769 mg/L 3compartmentss NA 95% Rat Human +DTXSID80190615 Css NA 0.003383 mg/L PBTK NA 50% Rat Human +DTXSID80190615 Css NA 0.02204 mg/L PBTK NA 95% Rat Human +DTXSID80191501 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80191501 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80191501 Vd NA 1.536 L/kg 1compartment NA NA Human Human +DTXSID80191501 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID80191501 TK.Half.Life NA 20.9 hours 1compartment NA NA Human Human +DTXSID80191501 Css NA 2.064 mg/L 3compartmentss NA 50% Human Human +DTXSID80191501 Css NA 13.92 mg/L 3compartmentss NA 95% Human Human +DTXSID80191501 Css NA 1.321 mg/L PBTK NA 50% Human Human +DTXSID80191501 Css NA 8.522 mg/L PBTK NA 95% Human Human +DTXSID80191501 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80191501 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80191501 Vd NA 1.154 L/kg 1compartment NA NA Rat Human +DTXSID80191501 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID80191501 TK.Half.Life NA 7.789 hours 1compartment NA NA Rat Human +DTXSID80191501 Css NA 0.2549 mg/L 3compartmentss NA 50% Rat Human +DTXSID80191501 Css NA 1.28 mg/L 3compartmentss NA 95% Rat Human +DTXSID80191501 Css NA 0.1586 mg/L PBTK NA 50% Rat Human +DTXSID80191501 Css NA 0.7618 mg/L PBTK NA 95% Rat Human +DTXSID80196152 Clint 35.53 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80196152 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80196152 Vd NA 2.09 L/kg 1compartment NA NA Human Human +DTXSID80196152 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80196152 TK.Half.Life NA 4.596 hours 1compartment NA NA Human Human +DTXSID80196152 Css NA 0.1951 mg/L 3compartmentss NA 50% Human Human +DTXSID80196152 Css NA 1.482 mg/L 3compartmentss NA 95% Human Human +DTXSID80196152 Css NA 0.1345 mg/L PBTK NA 50% Human Human +DTXSID80196152 Css NA 0.9615 mg/L PBTK NA 95% Human Human +DTXSID80196152 Clint 35.53 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80196152 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80196152 Vd NA 1.586 L/kg 1compartment NA NA Rat Human +DTXSID80196152 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80196152 TK.Half.Life NA 1.494 hours 1compartment NA NA Rat Human +DTXSID80196152 Css NA 0.02559 mg/L 3compartmentss NA 50% Rat Human +DTXSID80196152 Css NA 0.152 mg/L 3compartmentss NA 95% Rat Human +DTXSID80196152 Css NA 0.01721 mg/L PBTK NA 50% Rat Human +DTXSID80196152 Css NA 0.09836 mg/L PBTK NA 95% Rat Human +DTXSID80197780 Clint 27.79 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80197780 Fup 0.036 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80197780 Vd NA 2.643 L/kg 1compartment NA NA Human Human +DTXSID80197780 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID80197780 TK.Half.Life NA 20.8 hours 1compartment NA NA Human Human +DTXSID80197780 Css NA 0.9824 mg/L 3compartmentss NA 50% Human Human +DTXSID80197780 Css NA 6.669 mg/L 3compartmentss NA 95% Human Human +DTXSID80197780 Css NA 0.6601 mg/L PBTK NA 50% Human Human +DTXSID80197780 Css NA 4.31 mg/L PBTK NA 95% Human Human +DTXSID80197780 Clint 27.79 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80197780 Fup 0.036 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80197780 Vd NA 1.977 L/kg 1compartment NA NA Rat Human +DTXSID80197780 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID80197780 TK.Half.Life NA 4.777 hours 1compartment NA NA Rat Human +DTXSID80197780 Css NA 0.129 mg/L 3compartmentss NA 50% Rat Human +DTXSID80197780 Css NA 0.7349 mg/L 3compartmentss NA 95% Rat Human +DTXSID80197780 Css NA 0.08532 mg/L PBTK NA 50% Rat Human +DTXSID80197780 Css NA 0.469 mg/L PBTK NA 95% Rat Human +DTXSID80198318 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80198318 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80198318 Vd NA 2.939 L/kg 1compartment NA NA Human Human +DTXSID80198318 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID80198318 TK.Half.Life NA 32.53 hours 1compartment NA NA Human Human +DTXSID80198318 Css NA 1.148 mg/L 3compartmentss NA 50% Human Human +DTXSID80198318 Css NA 7.453 mg/L 3compartmentss NA 95% Human Human +DTXSID80198318 Css NA 0.7936 mg/L PBTK NA 50% Human Human +DTXSID80198318 Css NA 5.016 mg/L PBTK NA 95% Human Human +DTXSID80198318 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80198318 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80198318 Vd NA 2.205 L/kg 1compartment NA NA Rat Human +DTXSID80198318 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID80198318 TK.Half.Life NA 5.738 hours 1compartment NA NA Rat Human +DTXSID80198318 Css NA 0.05769 mg/L 3compartmentss NA 50% Rat Human +DTXSID80198318 Css NA 0.384 mg/L 3compartmentss NA 95% Rat Human +DTXSID80198318 Css NA 0.03871 mg/L PBTK NA 50% Rat Human +DTXSID80198318 Css NA 0.2465 mg/L PBTK NA 95% Rat Human +DTXSID80198994 Clint 11.55 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80198994 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80198994 Vd NA 0.4884 L/kg 1compartment NA NA Human Human +DTXSID80198994 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80198994 TK.Half.Life NA 0.9259 hours 1compartment NA NA Human Human +DTXSID80198994 Css NA 0.141 mg/L 3compartmentss NA 50% Human Human +DTXSID80198994 Css NA 0.9587 mg/L 3compartmentss NA 95% Human Human +DTXSID80198994 Css NA 0.1001 mg/L PBTK NA 50% Human Human +DTXSID80198994 Css NA 0.6436 mg/L PBTK NA 95% Human Human +DTXSID80198994 Clint 11.55 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80198994 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80198994 Vd NA 0.4853 L/kg 1compartment NA NA Rat Human +DTXSID80198994 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80198994 TK.Half.Life NA 0.5219 hours 1compartment NA NA Rat Human +DTXSID80198994 Css NA 0.01732 mg/L 3compartmentss NA 50% Rat Human +DTXSID80198994 Css NA 0.08642 mg/L 3compartmentss NA 95% Rat Human +DTXSID80198994 Css NA 0.0123 mg/L PBTK NA 50% Rat Human +DTXSID80198994 Css NA 0.05638 mg/L PBTK NA 95% Rat Human +DTXSID80199966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80199966 Fup 0.0428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80199966 Vd NA 1.443 L/kg 1compartment NA NA Human Human +DTXSID80199966 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80199966 TK.Half.Life NA 7.515 hours 1compartment NA NA Human Human +DTXSID80199966 Css NA 0.7193 mg/L 3compartmentss NA 50% Human Human +DTXSID80199966 Css NA 5.858 mg/L 3compartmentss NA 95% Human Human +DTXSID80199966 Css NA 0.4572 mg/L PBTK NA 50% Human Human +DTXSID80199966 Css NA 3.489 mg/L PBTK NA 95% Human Human +DTXSID80199966 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80199966 Fup 0.0428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80199966 Vd NA 1.082 L/kg 1compartment NA NA Rat Human +DTXSID80199966 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80199966 TK.Half.Life NA 2.943 hours 1compartment NA NA Rat Human +DTXSID80199966 Css NA 0.09426 mg/L 3compartmentss NA 50% Rat Human +DTXSID80199966 Css NA 0.6182 mg/L 3compartmentss NA 95% Rat Human +DTXSID80199966 Css NA 0.05819 mg/L PBTK NA 50% Rat Human +DTXSID80199966 Css NA 0.3625 mg/L PBTK NA 95% Rat Human DTXSID8020044 Clint NA 0.00737 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020044 Fup NA 0.7016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020044 Vd NA 0.7975 L/kg 1compartment NA NA Human Human DTXSID8020044 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8020044 TK.Half.Life NA 7.321 hours 1compartment NA NA Human Human -DTXSID8020044 Css NA 1.046 mg/L 3compartmentss NA 50% Human Human -DTXSID8020044 Css NA 6.516 mg/L 3compartmentss NA 95% Human Human -DTXSID8020044 Css NA 0.8688 mg/L PBTK NA 50% Human Human -DTXSID8020044 Css NA 4.24 mg/L PBTK NA 95% Human Human +DTXSID8020044 Css NA 0.893 mg/L 3compartmentss NA 50% Human Human +DTXSID8020044 Css NA 5.416 mg/L 3compartmentss NA 95% Human Human +DTXSID8020044 Css NA 0.7406 mg/L PBTK NA 50% Human Human +DTXSID8020044 Css NA 3.495 mg/L PBTK NA 95% Human Human DTXSID8020044 Clint NA 0.00737 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020044 Fup NA 0.7016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020044 Vd NA 0.799 L/kg 1compartment NA NA Rat Human DTXSID8020044 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8020044 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human -DTXSID8020044 Css NA 0.2727 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020044 Css NA 1.839 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020044 Css NA 0.2189 mg/L PBTK NA 50% Rat Human -DTXSID8020044 Css NA 1.09 mg/L PBTK NA 95% Rat Human -DTXSID8020090 Clint NA 2.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020090 Fup NA 0.8408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020090 Vd NA 1.18 L/kg 1compartment NA NA Human Human +DTXSID8020044 Css NA 0.01729 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020044 Css NA 0.1457 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020044 Css NA 0.01376 mg/L PBTK NA 50% Rat Human +DTXSID8020044 Css NA 0.09438 mg/L PBTK NA 95% Rat Human +DTXSID8020090 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020090 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020090 Vd NA 0.8238 L/kg 1compartment NA NA Human Human DTXSID8020090 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020090 TK.Half.Life NA 2.256 hours 1compartment NA NA Human Human -DTXSID8020090 Css NA 0.1823 mg/L 3compartmentss NA 50% Human Human -DTXSID8020090 Css NA 1.364 mg/L 3compartmentss NA 95% Human Human -DTXSID8020090 Css NA 0.1613 mg/L PBTK NA 50% Human Human -DTXSID8020090 Css NA 0.9489 mg/L PBTK NA 95% Human Human -DTXSID8020090 Clint NA 2.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020090 Fup NA 0.8408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020090 Vd NA 1.118 L/kg 1compartment NA NA Rat Human +DTXSID8020090 TK.Half.Life NA 0.8498 hours 1compartment NA NA Human Human +DTXSID8020090 Css NA 0.03331 mg/L 3compartmentss NA 50% Human Human +DTXSID8020090 Css NA 0.3038 mg/L 3compartmentss NA 95% Human Human +DTXSID8020090 Css NA 0.02598 mg/L PBTK NA 50% Human Human +DTXSID8020090 Css NA 0.2125 mg/L PBTK NA 95% Human Human +DTXSID8020090 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020090 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020090 Vd NA 0.7759 L/kg 1compartment NA NA Rat Human DTXSID8020090 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020090 TK.Half.Life NA 1.097 hours 1compartment NA NA Rat Human -DTXSID8020090 Css NA 0.07895 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020090 Css NA 0.5189 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020090 Css NA 0.06945 mg/L PBTK NA 50% Rat Human -DTXSID8020090 Css NA 0.3249 mg/L PBTK NA 95% Rat Human -DTXSID8020092 Clint NA 41.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020092 Fup NA 0.7028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020092 Vd NA 1.23 L/kg 1compartment NA NA Human Human +DTXSID8020090 TK.Half.Life NA 0.4056 hours 1compartment NA NA Rat Human +DTXSID8020090 Css NA 0.001178 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020090 Css NA 0.01268 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020090 Css NA 0.0009051 mg/L PBTK NA 50% Rat Human +DTXSID8020090 Css NA 0.008588 mg/L PBTK NA 95% Rat Human +DTXSID8020092 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020092 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020092 Vd NA 1.594 L/kg 1compartment NA NA Human Human DTXSID8020092 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020092 TK.Half.Life NA 0.8636 hours 1compartment NA NA Human Human -DTXSID8020092 Css NA 0.01637 mg/L 3compartmentss NA 50% Human Human -DTXSID8020092 Css NA 0.1685 mg/L 3compartmentss NA 95% Human Human -DTXSID8020092 Css NA 0.01417 mg/L PBTK NA 50% Human Human -DTXSID8020092 Css NA 0.1233 mg/L PBTK NA 95% Human Human -DTXSID8020092 Clint NA 41.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020092 Fup NA 0.7028 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020092 Vd NA 1.126 L/kg 1compartment NA NA Rat Human +DTXSID8020092 TK.Half.Life NA 2.037 hours 1compartment NA NA Human Human +DTXSID8020092 Css NA 0.06644 mg/L 3compartmentss NA 50% Human Human +DTXSID8020092 Css NA 0.4732 mg/L 3compartmentss NA 95% Human Human +DTXSID8020092 Css NA 0.0512 mg/L PBTK NA 50% Human Human +DTXSID8020092 Css NA 0.3408 mg/L PBTK NA 95% Human Human +DTXSID8020092 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020092 Fup 0.348 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020092 Vd NA 1.295 L/kg 1compartment NA NA Rat Human DTXSID8020092 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020092 TK.Half.Life NA 0.3675 hours 1compartment NA NA Rat Human -DTXSID8020092 Css NA 0.008254 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020092 Css NA 0.08164 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020092 Css NA 0.00713 mg/L PBTK NA 50% Rat Human -DTXSID8020092 Css NA 0.05573 mg/L PBTK NA 95% Rat Human -DTXSID8020094 Clint NA 0.8533 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020094 Fup NA 0.1841 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020094 Vd NA 0.4103 L/kg 1compartment NA NA Human Human +DTXSID8020092 TK.Half.Life NA 0.7964 hours 1compartment NA NA Rat Human +DTXSID8020092 Css NA 0.008183 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020092 Css NA 0.04597 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020092 Css NA 0.006386 mg/L PBTK NA 50% Rat Human +DTXSID8020092 Css NA 0.0326 mg/L PBTK NA 95% Rat Human +DTXSID8020094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020094 Fup 0.352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020094 Vd NA 0.579 L/kg 1compartment NA NA Human Human DTXSID8020094 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020094 TK.Half.Life NA 6.048 hours 1compartment NA NA Human Human -DTXSID8020094 Css NA 1.786 mg/L 3compartmentss NA 50% Human Human -DTXSID8020094 Css NA 7.781 mg/L 3compartmentss NA 95% Human Human -DTXSID8020094 Css NA 1.2 mg/L PBTK NA 50% Human Human -DTXSID8020094 Css NA 4.749 mg/L PBTK NA 95% Human Human -DTXSID8020094 Clint NA 0.8533 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020094 Fup NA 0.1841 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020094 Vd NA 0.412 L/kg 1compartment NA NA Rat Human +DTXSID8020094 TK.Half.Life NA 0.6822 hours 1compartment NA NA Human Human +DTXSID8020094 Css NA 0.05342 mg/L 3compartmentss NA 50% Human Human +DTXSID8020094 Css NA 0.4487 mg/L 3compartmentss NA 95% Human Human +DTXSID8020094 Css NA 0.03997 mg/L PBTK NA 50% Human Human +DTXSID8020094 Css NA 0.3032 mg/L PBTK NA 95% Human Human +DTXSID8020094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020094 Fup 0.352 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020094 Vd NA 0.5844 L/kg 1compartment NA NA Rat Human DTXSID8020094 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020094 TK.Half.Life NA 2.936 hours 1compartment NA NA Rat Human -DTXSID8020094 Css NA 0.7203 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020094 Css NA 2.465 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020094 Css NA 0.4562 mg/L PBTK NA 50% Rat Human -DTXSID8020094 Css NA 1.416 mg/L PBTK NA 95% Rat Human -DTXSID8020121 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020121 Fup NA 0.2491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020121 Vd NA 3.136 L/kg 1compartment NA NA Human Human -DTXSID8020121 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID8020121 TK.Half.Life NA 112500 hours 1compartment NA NA Human Human -DTXSID8020121 Css NA 4024 mg/L 3compartmentss NA 50% Human Human -DTXSID8020121 Css NA 10030 mg/L 3compartmentss NA 95% Human Human -DTXSID8020121 Css NA 2812 mg/L PBTK NA 50% Human Human -DTXSID8020121 Css NA 6597 mg/L PBTK NA 95% Human Human -DTXSID8020121 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020121 Fup NA 0.2491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020121 Vd NA 2.349 L/kg 1compartment NA NA Rat Human -DTXSID8020121 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID8020121 TK.Half.Life NA 6856 hours 1compartment NA NA Rat Human -DTXSID8020121 Css NA 1096 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020121 Css NA 2171 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020121 Css NA 731.8 mg/L PBTK NA 50% Rat Human -DTXSID8020121 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID8020094 TK.Half.Life NA 0.361 hours 1compartment NA NA Rat Human +DTXSID8020094 Css NA 0.006717 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020094 Css NA 0.04134 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020094 Css NA 0.004998 mg/L PBTK NA 50% Rat Human +DTXSID8020094 Css NA 0.02771 mg/L PBTK NA 95% Rat Human DTXSID8020127 Clint 2.414 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8020127 Fup 0.914 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8020127 Vd NA 1.567 L/kg 1compartment NA NA Human Human +DTXSID8020127 Vd NA 0.9475 L/kg 1compartment NA NA Human Human DTXSID8020127 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020127 TK.Half.Life NA 2.775 hours 1compartment NA NA Human Human -DTXSID8020127 Css NA 0.17 mg/L 3compartmentss NA 50% Human Human -DTXSID8020127 Css NA 0.8474 mg/L 3compartmentss NA 95% Human Human -DTXSID8020127 Css NA 0.151 mg/L PBTK NA 50% Human Human -DTXSID8020127 Css NA 0.6411 mg/L PBTK NA 95% Human Human +DTXSID8020127 TK.Half.Life NA 1.669 hours 1compartment NA NA Human Human +DTXSID8020127 Css NA 0.1429 mg/L 3compartmentss NA 50% Human Human +DTXSID8020127 Css NA 0.6494 mg/L 3compartmentss NA 95% Human Human +DTXSID8020127 Css NA 0.1392 mg/L PBTK NA 50% Human Human +DTXSID8020127 Css NA 0.6342 mg/L PBTK NA 95% Human Human DTXSID8020127 Clint 2.917 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8020127 Fup 0.786 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat -DTXSID8020127 Vd NA 1.417 L/kg 1compartment NA NA Rat Rat +DTXSID8020127 Vd NA 0.8628 L/kg 1compartment NA NA Rat Rat DTXSID8020127 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8020127 TK.Half.Life NA 1.35 hours 1compartment NA NA Rat Rat -DTXSID8020127 Css NA 0.07167 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8020127 Css NA 0.5211 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8020127 Css NA 0.06487 mg/L PBTK NA 50% Rat Rat -DTXSID8020127 Css NA 0.3315 mg/L PBTK NA 95% Rat Rat +DTXSID8020127 TK.Half.Life NA 0.822 hours 1compartment NA NA Rat Rat +DTXSID8020127 Css NA 0.0107 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8020127 Css NA 0.05815 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8020127 Css NA 0.0108 mg/L PBTK NA 50% Rat Rat +DTXSID8020127 Css NA 0.05845 mg/L PBTK NA 95% Rat Rat DTXSID8020129 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020129 Fup NA 0.7602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020129 Vd NA 0.4475 L/kg 1compartment NA NA Human Human DTXSID8020129 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8020129 TK.Half.Life NA 3.809 hours 1compartment NA NA Human Human -DTXSID8020129 Css NA 1.154 mg/L 3compartmentss NA 50% Human Human -DTXSID8020129 Css NA 6.638 mg/L 3compartmentss NA 95% Human Human -DTXSID8020129 Css NA 0.8407 mg/L PBTK NA 50% Human Human -DTXSID8020129 Css NA 4.097 mg/L PBTK NA 95% Human Human +DTXSID8020129 Css NA 0.7997 mg/L 3compartmentss NA 50% Human Human +DTXSID8020129 Css NA 4.656 mg/L 3compartmentss NA 95% Human Human +DTXSID8020129 Css NA 0.5866 mg/L PBTK NA 50% Human Human +DTXSID8020129 Css NA 2.904 mg/L PBTK NA 95% Human Human DTXSID8020129 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020129 Fup NA 0.7602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020129 Vd NA 0.4724 L/kg 1compartment NA NA Rat Human DTXSID8020129 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8020129 TK.Half.Life NA 1.37 hours 1compartment NA NA Rat Human -DTXSID8020129 Css NA 0.3005 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020129 Css NA 1.737 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020129 Css NA 0.2099 mg/L PBTK NA 50% Rat Human -DTXSID8020129 Css NA 0.9958 mg/L PBTK NA 95% Rat Human -DTXSID8020175 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020175 Fup NA 0.0161 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020175 Vd NA 2.164 L/kg 1compartment NA NA Human Human -DTXSID8020175 Days.Css NA 519 Days PBTK NA NA Human Human -DTXSID8020175 TK.Half.Life NA 1965 hours 1compartment NA NA Human Human -DTXSID8020175 Css NA 131.1 mg/L 3compartmentss NA 50% Human Human -DTXSID8020175 Css NA 547.4 mg/L 3compartmentss NA 95% Human Human -DTXSID8020175 Css NA 85.01 mg/L PBTK NA 50% Human Human -DTXSID8020175 Css NA 328.5 mg/L PBTK NA 95% Human Human -DTXSID8020175 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020175 Fup NA 0.0161 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020175 Vd NA 1.608 L/kg 1compartment NA NA Rat Human -DTXSID8020175 Days.Css NA 128 Days PBTK NA NA Rat Human -DTXSID8020175 TK.Half.Life NA 286.4 hours 1compartment NA NA Rat Human -DTXSID8020175 Css NA 36.18 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020175 Css NA 127.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020175 Css NA 22.1 mg/L PBTK NA 50% Rat Human -DTXSID8020175 Css NA 71.84 mg/L PBTK NA 95% Rat Human -DTXSID8020179 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020179 Fup NA 0.888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020179 Vd NA 1.899 L/kg 1compartment NA NA Human Human -DTXSID8020179 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020179 TK.Half.Life NA 1.935 hours 1compartment NA NA Human Human -DTXSID8020179 Css NA 0.0716 mg/L 3compartmentss NA 50% Human Human -DTXSID8020179 Css NA 0.635 mg/L 3compartmentss NA 95% Human Human -DTXSID8020179 Css NA 0.07053 mg/L PBTK NA 50% Human Human -DTXSID8020179 Css NA 0.4761 mg/L PBTK NA 95% Human Human -DTXSID8020179 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020179 Fup NA 0.888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020179 Vd NA 1.934 L/kg 1compartment NA NA Rat Human +DTXSID8020129 Css NA 0.006136 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020129 Css NA 0.04967 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020129 Css NA 0.00427 mg/L PBTK NA 50% Rat Human +DTXSID8020129 Css NA 0.03119 mg/L PBTK NA 95% Rat Human +DTXSID8020175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020175 Fup 0.00404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020175 Vd NA 1.827 L/kg 1compartment NA NA Human Human +DTXSID8020175 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8020175 TK.Half.Life NA 46.3 hours 1compartment NA NA Human Human +DTXSID8020175 Css NA 4.015 mg/L 3compartmentss NA 50% Human Human +DTXSID8020175 Css NA 29.41 mg/L 3compartmentss NA 95% Human Human +DTXSID8020175 Css NA 2.512 mg/L PBTK NA 50% Human Human +DTXSID8020175 Css NA 17.85 mg/L PBTK NA 95% Human Human +DTXSID8020175 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020175 Fup 0.00404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020175 Vd NA 1.347 L/kg 1compartment NA NA Rat Human +DTXSID8020175 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8020175 TK.Half.Life NA 15.91 hours 1compartment NA NA Rat Human +DTXSID8020175 Css NA 0.5274 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020175 Css NA 3.272 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020175 Css NA 0.3227 mg/L PBTK NA 50% Rat Human +DTXSID8020175 Css NA 1.969 mg/L PBTK NA 95% Rat Human +DTXSID8020179 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020179 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020179 Vd NA 1.646 L/kg 1compartment NA NA Human Human +DTXSID8020179 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8020179 TK.Half.Life NA 14.81 hours 1compartment NA NA Human Human +DTXSID8020179 Css NA 0.7667 mg/L 3compartmentss NA 50% Human Human +DTXSID8020179 Css NA 5.56 mg/L 3compartmentss NA 95% Human Human +DTXSID8020179 Css NA 0.7352 mg/L PBTK NA 50% Human Human +DTXSID8020179 Css NA 3.789 mg/L PBTK NA 95% Human Human +DTXSID8020179 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020179 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020179 Vd NA 1.674 L/kg 1compartment NA NA Rat Human DTXSID8020179 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020179 TK.Half.Life NA 1.057 hours 1compartment NA NA Rat Human -DTXSID8020179 Css NA 0.03338 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020179 Css NA 0.2441 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020179 Css NA 0.03342 mg/L PBTK NA 50% Rat Human -DTXSID8020179 Css NA 0.1727 mg/L PBTK NA 95% Rat Human +DTXSID8020179 TK.Half.Life NA 5.134 hours 1compartment NA NA Rat Human +DTXSID8020179 Css NA 0.01447 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020179 Css NA 0.1352 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020179 Css NA 0.01354 mg/L PBTK NA 50% Rat Human +DTXSID8020179 Css NA 0.09281 mg/L PBTK NA 95% Rat Human DTXSID8020200 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020200 Fup NA 0.7868 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020200 Vd NA 0.8702 L/kg 1compartment NA NA Human Human DTXSID8020200 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8020200 TK.Half.Life NA 7.226 hours 1compartment NA NA Human Human -DTXSID8020200 Css NA 0.9718 mg/L 3compartmentss NA 50% Human Human -DTXSID8020200 Css NA 6.153 mg/L 3compartmentss NA 95% Human Human -DTXSID8020200 Css NA 0.8258 mg/L PBTK NA 50% Human Human -DTXSID8020200 Css NA 4.03 mg/L PBTK NA 95% Human Human +DTXSID8020200 Css NA 0.8318 mg/L 3compartmentss NA 50% Human Human +DTXSID8020200 Css NA 5.368 mg/L 3compartmentss NA 95% Human Human +DTXSID8020200 Css NA 0.7058 mg/L PBTK NA 50% Human Human +DTXSID8020200 Css NA 3.491 mg/L PBTK NA 95% Human Human DTXSID8020200 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020200 Fup NA 0.7868 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020200 Vd NA 0.87 L/kg 1compartment NA NA Rat Human DTXSID8020200 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8020200 TK.Half.Life NA 2.443 hours 1compartment NA NA Rat Human -DTXSID8020200 Css NA 0.2496 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020200 Css NA 1.537 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020200 Css NA 0.2058 mg/L PBTK NA 50% Rat Human -DTXSID8020200 Css NA 0.9268 mg/L PBTK NA 95% Rat Human -DTXSID8020202 Clint NA 38.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8020200 Css NA 0.01568 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020200 Css NA 0.1178 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020200 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID8020200 Css NA 0.07894 mg/L PBTK NA 95% Rat Human +DTXSID8020202 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8020202 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8020202 Vd NA 1.559 L/kg 1compartment NA NA Human Human +DTXSID8020202 Vd NA 0.7413 L/kg 1compartment NA NA Human Human DTXSID8020202 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020202 TK.Half.Life NA 2.701 hours 1compartment NA NA Human Human -DTXSID8020202 Css NA 0.1377 mg/L 3compartmentss NA 50% Human Human -DTXSID8020202 Css NA 1.1 mg/L 3compartmentss NA 95% Human Human -DTXSID8020202 Css NA 0.0934 mg/L PBTK NA 50% Human Human -DTXSID8020202 Css NA 0.7005 mg/L PBTK NA 95% Human Human -DTXSID8020202 Clint NA 38.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8020202 TK.Half.Life NA 3.817 hours 1compartment NA NA Human Human +DTXSID8020202 Css NA 0.6664 mg/L 3compartmentss NA 50% Human Human +DTXSID8020202 Css NA 4.585 mg/L 3compartmentss NA 95% Human Human +DTXSID8020202 Css NA 0.4317 mg/L PBTK NA 50% Human Human +DTXSID8020202 Css NA 2.78 mg/L PBTK NA 95% Human Human +DTXSID8020202 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8020202 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8020202 Vd NA 1.195 L/kg 1compartment NA NA Rat Human +DTXSID8020202 Vd NA 0.6082 L/kg 1compartment NA NA Rat Human DTXSID8020202 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020202 TK.Half.Life NA 1.004 hours 1compartment NA NA Rat Human -DTXSID8020202 Css NA 0.07778 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020202 Css NA 0.4668 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020202 Css NA 0.04994 mg/L PBTK NA 50% Rat Human -DTXSID8020202 Css NA 0.2856 mg/L PBTK NA 95% Rat Human -DTXSID8020252 Clint NA 0.3653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020252 Fup NA 0.5032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020252 Vd NA 1.268 L/kg 1compartment NA NA Human Human -DTXSID8020252 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8020252 TK.Half.Life NA 11.4 hours 1compartment NA NA Human Human -DTXSID8020252 Css NA 0.8894 mg/L 3compartmentss NA 50% Human Human -DTXSID8020252 Css NA 4.662 mg/L 3compartmentss NA 95% Human Human -DTXSID8020252 Css NA 0.7445 mg/L PBTK NA 50% Human Human -DTXSID8020252 Css NA 3.106 mg/L PBTK NA 95% Human Human -DTXSID8020252 Clint NA 0.3653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020252 Fup NA 0.5032 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020252 Vd NA 1.104 L/kg 1compartment NA NA Rat Human +DTXSID8020202 TK.Half.Life NA 1.818 hours 1compartment NA NA Rat Human +DTXSID8020202 Css NA 0.07691 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020202 Css NA 0.4029 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020202 Css NA 0.04852 mg/L PBTK NA 50% Rat Human +DTXSID8020202 Css NA 0.2388 mg/L PBTK NA 95% Rat Human +DTXSID8020252 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020252 Fup 0.483 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020252 Vd NA 1.239 L/kg 1compartment NA NA Human Human +DTXSID8020252 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8020252 TK.Half.Life NA 18.61 hours 1compartment NA NA Human Human +DTXSID8020252 Css NA 1.487 mg/L 3compartmentss NA 50% Human Human +DTXSID8020252 Css NA 6.962 mg/L 3compartmentss NA 95% Human Human +DTXSID8020252 Css NA 1.223 mg/L PBTK NA 50% Human Human +DTXSID8020252 Css NA 4.721 mg/L PBTK NA 95% Human Human +DTXSID8020252 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020252 Fup 0.483 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020252 Vd NA 1.079 L/kg 1compartment NA NA Rat Human DTXSID8020252 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020252 TK.Half.Life NA 3.836 hours 1compartment NA NA Rat Human -DTXSID8020252 Css NA 0.3049 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020252 Css NA 1.437 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020252 Css NA 0.2446 mg/L PBTK NA 50% Rat Human -DTXSID8020252 Css NA 0.8865 mg/L PBTK NA 95% Rat Human -DTXSID8020331 Clint NA 4.354 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020331 Fup NA 0.0098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020331 Vd NA 0.2137 L/kg 1compartment NA NA Human Human -DTXSID8020331 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8020331 TK.Half.Life NA 17.16 hours 1compartment NA NA Human Human -DTXSID8020331 Css NA 14.88 mg/L 3compartmentss NA 50% Human Human -DTXSID8020331 Css NA 121.6 mg/L 3compartmentss NA 95% Human Human -DTXSID8020331 Css NA 8.768 mg/L PBTK NA 50% Human Human -DTXSID8020331 Css NA 69.37 mg/L PBTK NA 95% Human Human -DTXSID8020331 Clint NA 4.354 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020331 Fup NA 0.0098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020331 Vd NA 0.2054 L/kg 1compartment NA NA Rat Human -DTXSID8020331 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8020331 TK.Half.Life NA 10.22 hours 1compartment NA NA Rat Human -DTXSID8020331 Css NA 7.731 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020331 Css NA 49.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020331 Css NA 4.253 mg/L PBTK NA 50% Rat Human -DTXSID8020331 Css NA 26.87 mg/L PBTK NA 95% Rat Human -DTXSID8020337 Clint NA 104.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020337 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020337 Vd NA 2.987 L/kg 1compartment NA NA Human Human +DTXSID8020252 TK.Half.Life NA 5.067 hours 1compartment NA NA Rat Human +DTXSID8020252 Css NA 0.09406 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020252 Css NA 0.4113 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020252 Css NA 0.07736 mg/L PBTK NA 50% Rat Human +DTXSID8020252 Css NA 0.2619 mg/L PBTK NA 95% Rat Human +DTXSID8020256 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020256 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020256 Vd NA 1.652 L/kg 1compartment NA NA Human Human +DTXSID8020256 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8020256 TK.Half.Life NA 2.679 hours 1compartment NA NA Human Human +DTXSID8020256 Css NA 0.1038 mg/L 3compartmentss NA 50% Human Human +DTXSID8020256 Css NA 0.7069 mg/L 3compartmentss NA 95% Human Human +DTXSID8020256 Css NA 0.07646 mg/L PBTK NA 50% Human Human +DTXSID8020256 Css NA 0.4828 mg/L PBTK NA 95% Human Human +DTXSID8020256 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020256 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020256 Vd NA 1.304 L/kg 1compartment NA NA Rat Human +DTXSID8020256 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8020256 TK.Half.Life NA 1.016 hours 1compartment NA NA Rat Human +DTXSID8020256 Css NA 0.01303 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020256 Css NA 0.06826 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020256 Css NA 0.00959 mg/L PBTK NA 50% Rat Human +DTXSID8020256 Css NA 0.04826 mg/L PBTK NA 95% Rat Human +DTXSID8020331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020331 Fup 0.0466 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020331 Vd NA 0.3915 L/kg 1compartment NA NA Human Human +DTXSID8020331 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8020331 TK.Half.Life NA 1.778 hours 1compartment NA NA Human Human +DTXSID8020331 Css NA 0.6363 mg/L 3compartmentss NA 50% Human Human +DTXSID8020331 Css NA 4.984 mg/L 3compartmentss NA 95% Human Human +DTXSID8020331 Css NA 0.4027 mg/L PBTK NA 50% Human Human +DTXSID8020331 Css NA 2.989 mg/L PBTK NA 95% Human Human +DTXSID8020331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020331 Fup 0.0466 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020331 Vd NA 0.371 L/kg 1compartment NA NA Rat Human +DTXSID8020331 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8020331 TK.Half.Life NA 1.065 hours 1compartment NA NA Rat Human +DTXSID8020331 Css NA 0.08355 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020331 Css NA 0.5179 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020331 Css NA 0.05108 mg/L PBTK NA 50% Rat Human +DTXSID8020331 Css NA 0.3049 mg/L PBTK NA 95% Rat Human +DTXSID8020337 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020337 Fup 0.0873 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020337 Vd NA 0.5959 L/kg 1compartment NA NA Human Human DTXSID8020337 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020337 TK.Half.Life NA 3.588 hours 1compartment NA NA Human Human -DTXSID8020337 Css NA 0.05684 mg/L 3compartmentss NA 50% Human Human -DTXSID8020337 Css NA 0.392 mg/L 3compartmentss NA 95% Human Human -DTXSID8020337 Css NA 0.03988 mg/L PBTK NA 50% Human Human -DTXSID8020337 Css NA 0.2601 mg/L PBTK NA 95% Human Human -DTXSID8020337 Clint NA 104.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020337 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020337 Vd NA 2.312 L/kg 1compartment NA NA Rat Human +DTXSID8020337 TK.Half.Life NA 4.316 hours 1compartment NA NA Human Human +DTXSID8020337 Css NA 1.048 mg/L 3compartmentss NA 50% Human Human +DTXSID8020337 Css NA 7.328 mg/L 3compartmentss NA 95% Human Human +DTXSID8020337 Css NA 0.6674 mg/L PBTK NA 50% Human Human +DTXSID8020337 Css NA 4.402 mg/L PBTK NA 95% Human Human +DTXSID8020337 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020337 Fup 0.0873 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020337 Vd NA 0.5885 L/kg 1compartment NA NA Rat Human DTXSID8020337 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020337 TK.Half.Life NA 1.055 hours 1compartment NA NA Rat Human -DTXSID8020337 Css NA 0.03149 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020337 Css NA 0.1884 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020337 Css NA 0.02123 mg/L PBTK NA 50% Rat Human -DTXSID8020337 Css NA 0.1205 mg/L PBTK NA 95% Rat Human -DTXSID8020381 Clint NA 122.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8020337 TK.Half.Life NA 2.62 hours 1compartment NA NA Rat Human +DTXSID8020337 Css NA 0.1291 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020337 Css NA 0.6782 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020337 Css NA 0.07988 mg/L PBTK NA 50% Rat Human +DTXSID8020337 Css NA 0.3954 mg/L PBTK NA 95% Rat Human +DTXSID8020381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8020381 Fup 0.01 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID8020381 Vd NA 4.24 L/kg 1compartment NA NA Human Human -DTXSID8020381 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8020381 TK.Half.Life NA 25.81 hours 1compartment NA NA Human Human -DTXSID8020381 Css NA 0.7548 mg/L 3compartmentss NA 50% Human Human -DTXSID8020381 Css NA 4.202 mg/L 3compartmentss NA 95% Human Human -DTXSID8020381 Css NA 0.4378 mg/L PBTK NA 50% Human Human -DTXSID8020381 Css NA 2.467 mg/L PBTK NA 95% Human Human +DTXSID8020381 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID8020381 TK.Half.Life NA 128.8 hours 1compartment NA NA Human Human +DTXSID8020381 Css NA 3.53 mg/L 3compartmentss NA 50% Human Human +DTXSID8020381 Css NA 20.42 mg/L 3compartmentss NA 95% Human Human +DTXSID8020381 Css NA 2.372 mg/L PBTK NA 50% Human Human +DTXSID8020381 Css NA 13.72 mg/L PBTK NA 95% Human Human DTXSID8020381 Clint 7 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID8020381 Fup 0.049 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID8020381 Vd NA 3.24 L/kg 1compartment NA NA Rat Rat -DTXSID8020381 Days.Css NA 49 Days PBTK NA NA Rat Rat +DTXSID8020381 Days.Css NA 48 Days PBTK NA NA Rat Rat DTXSID8020381 TK.Half.Life NA 50.59 hours 1compartment NA NA Rat Rat -DTXSID8020381 Css NA 7.418 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8020381 Css NA 31.75 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8020381 Css NA 4.008 mg/L PBTK NA 50% Rat Rat -DTXSID8020381 Css NA 17.16 mg/L PBTK NA 95% Rat Rat -DTXSID8020383 Clint NA 11.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020383 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020383 Vd NA 1.143 L/kg 1compartment NA NA Human Human -DTXSID8020383 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8020383 TK.Half.Life NA 11.34 hours 1compartment NA NA Human Human -DTXSID8020383 Css NA 1.637 mg/L 3compartmentss NA 50% Human Human -DTXSID8020383 Css NA 12.95 mg/L 3compartmentss NA 95% Human Human -DTXSID8020383 Css NA 1.033 mg/L PBTK NA 50% Human Human -DTXSID8020383 Css NA 7.906 mg/L PBTK NA 95% Human Human -DTXSID8020383 Clint NA 11.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020383 Fup NA 0.0333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020383 Vd NA 0.9327 L/kg 1compartment NA NA Rat Human +DTXSID8020381 Css NA 1.361 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8020381 Css NA 6.637 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8020381 Css NA 0.9465 mg/L PBTK NA 50% Rat Rat +DTXSID8020381 Css NA 4.618 mg/L PBTK NA 95% Rat Rat +DTXSID8020383 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020383 Fup 0.071 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020383 Vd NA 2.09 L/kg 1compartment NA NA Human Human +DTXSID8020383 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8020383 TK.Half.Life NA 9.187 hours 1compartment NA NA Human Human +DTXSID8020383 Css NA 0.4836 mg/L 3compartmentss NA 50% Human Human +DTXSID8020383 Css NA 3.227 mg/L 3compartmentss NA 95% Human Human +DTXSID8020383 Css NA 0.3244 mg/L PBTK NA 50% Human Human +DTXSID8020383 Css NA 2.073 mg/L PBTK NA 95% Human Human +DTXSID8020383 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020383 Fup 0.071 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020383 Vd NA 1.573 L/kg 1compartment NA NA Rat Human DTXSID8020383 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020383 TK.Half.Life NA 5.471 hours 1compartment NA NA Rat Human -DTXSID8020383 Css NA 0.9154 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020383 Css NA 5.435 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020383 Css NA 0.541 mg/L PBTK NA 50% Rat Human -DTXSID8020383 Css NA 3.05 mg/L PBTK NA 95% Rat Human -DTXSID8020410 Clint NA 39.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020410 Fup NA 0.0767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020410 Vd NA 2.999 L/kg 1compartment NA NA Human Human -DTXSID8020410 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8020410 TK.Half.Life NA 19.82 hours 1compartment NA NA Human Human -DTXSID8020410 Css NA 0.7464 mg/L 3compartmentss NA 50% Human Human -DTXSID8020410 Css NA 4.782 mg/L 3compartmentss NA 95% Human Human -DTXSID8020410 Css NA 0.5214 mg/L PBTK NA 50% Human Human -DTXSID8020410 Css NA 3.223 mg/L PBTK NA 95% Human Human -DTXSID8020410 Clint NA 39.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020410 Fup NA 0.0767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020410 Vd NA 2.25 L/kg 1compartment NA NA Rat Human -DTXSID8020410 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8020410 TK.Half.Life NA 3.481 hours 1compartment NA NA Rat Human -DTXSID8020410 Css NA 0.4214 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020410 Css NA 2.246 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020410 Css NA 0.28 mg/L PBTK NA 50% Rat Human -DTXSID8020410 Css NA 1.447 mg/L PBTK NA 95% Rat Human +DTXSID8020383 TK.Half.Life NA 2.912 hours 1compartment NA NA Rat Human +DTXSID8020383 Css NA 0.06227 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020383 Css NA 0.3221 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020383 Css NA 0.0413 mg/L PBTK NA 50% Rat Human +DTXSID8020383 Css NA 0.2097 mg/L PBTK NA 95% Rat Human +DTXSID8020410 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020410 Fup 0.00959 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020410 Vd NA 2.271 L/kg 1compartment NA NA Human Human +DTXSID8020410 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8020410 TK.Half.Life NA 38.32 hours 1compartment NA NA Human Human +DTXSID8020410 Css NA 2.472 mg/L 3compartmentss NA 50% Human Human +DTXSID8020410 Css NA 19.72 mg/L 3compartmentss NA 95% Human Human +DTXSID8020410 Css NA 1.608 mg/L PBTK NA 50% Human Human +DTXSID8020410 Css NA 12.21 mg/L PBTK NA 95% Human Human +DTXSID8020410 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020410 Fup 0.00959 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020410 Vd NA 1.687 L/kg 1compartment NA NA Rat Human +DTXSID8020410 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8020410 TK.Half.Life NA 10.75 hours 1compartment NA NA Rat Human +DTXSID8020410 Css NA 0.3251 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020410 Css NA 2.139 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020410 Css NA 0.2066 mg/L PBTK NA 50% Rat Human +DTXSID8020410 Css NA 1.3 mg/L PBTK NA 95% Rat Human DTXSID8020462 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020462 Fup 0.97 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID8020462 Vd NA 1.21 L/kg 1compartment NA NA Human Human -DTXSID8020462 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020462 TK.Half.Life NA 8.072 hours 1compartment NA NA Human Human -DTXSID8020462 Css NA 1.162 mg/L 3compartmentss NA 50% Human Human -DTXSID8020462 Css NA 5.575 mg/L 3compartmentss NA 95% Human Human -DTXSID8020462 Css NA 0.7303 mg/L PBTK NA 50% Human Human -DTXSID8020462 Css NA 3.393 mg/L PBTK NA 95% Human Human +DTXSID8020462 Vd NA 2.576 L/kg 1compartment NA NA Human Human +DTXSID8020462 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8020462 TK.Half.Life NA 18.81 hours 1compartment NA NA Human Human +DTXSID8020462 Css NA 1.021 mg/L 3compartmentss NA 50% Human Human +DTXSID8020462 Css NA 4.613 mg/L 3compartmentss NA 95% Human Human +DTXSID8020462 Css NA 0.6451 mg/L PBTK NA 50% Human Human +DTXSID8020462 Css NA 2.915 mg/L PBTK NA 95% Human Human DTXSID8020462 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020462 Fup 0.97 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID8020462 Vd NA 1.243 L/kg 1compartment NA NA Rat Human +DTXSID8020462 Vd NA 2.525 L/kg 1compartment NA NA Rat Human DTXSID8020462 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020462 TK.Half.Life NA 2.826 hours 1compartment NA NA Rat Human -DTXSID8020462 Css NA 0.3047 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020462 Css NA 1.316 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020462 Css NA 0.1818 mg/L PBTK NA 50% Rat Human -DTXSID8020462 Css NA 0.7291 mg/L PBTK NA 95% Rat Human -DTXSID8020464 Clint NA 86.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020464 Fup NA 0.6152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020464 Vd NA 0.9382 L/kg 1compartment NA NA Human Human +DTXSID8020462 TK.Half.Life NA 5.869 hours 1compartment NA NA Rat Human +DTXSID8020462 Css NA 0.01806 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020462 Css NA 0.1042 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020462 Css NA 0.01151 mg/L PBTK NA 50% Rat Human +DTXSID8020462 Css NA 0.06749 mg/L PBTK NA 95% Rat Human +DTXSID8020464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020464 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020464 Vd NA 1.799 L/kg 1compartment NA NA Human Human DTXSID8020464 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020464 TK.Half.Life NA 0.6436 hours 1compartment NA NA Human Human -DTXSID8020464 Css NA 0.008944 mg/L 3compartmentss NA 50% Human Human -DTXSID8020464 Css NA 0.1002 mg/L 3compartmentss NA 95% Human Human -DTXSID8020464 Css NA 0.007313 mg/L PBTK NA 50% Human Human -DTXSID8020464 Css NA 0.07072 mg/L PBTK NA 95% Human Human -DTXSID8020464 Clint NA 86.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020464 Fup NA 0.6152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020464 Vd NA 0.8931 L/kg 1compartment NA NA Rat Human +DTXSID8020464 TK.Half.Life NA 2.056 hours 1compartment NA NA Human Human +DTXSID8020464 Css NA 0.05372 mg/L 3compartmentss NA 50% Human Human +DTXSID8020464 Css NA 0.4176 mg/L 3compartmentss NA 95% Human Human +DTXSID8020464 Css NA 0.04356 mg/L PBTK NA 50% Human Human +DTXSID8020464 Css NA 0.3006 mg/L PBTK NA 95% Human Human +DTXSID8020464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020464 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020464 Vd NA 1.464 L/kg 1compartment NA NA Rat Human DTXSID8020464 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020464 TK.Half.Life NA 0.2776 hours 1compartment NA NA Rat Human -DTXSID8020464 Css NA 0.004644 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020464 Css NA 0.04711 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020464 Css NA 0.003746 mg/L PBTK NA 50% Rat Human -DTXSID8020464 Css NA 0.03119 mg/L PBTK NA 95% Rat Human -DTXSID8020466 Clint NA 2.169 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020466 Fup NA 0.9687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020466 Vd NA 1.117 L/kg 1compartment NA NA Human Human +DTXSID8020464 TK.Half.Life NA 0.7752 hours 1compartment NA NA Rat Human +DTXSID8020464 Css NA 0.0066 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020464 Css NA 0.0394 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020464 Css NA 0.005438 mg/L PBTK NA 50% Rat Human +DTXSID8020464 Css NA 0.02865 mg/L PBTK NA 95% Rat Human +DTXSID8020466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020466 Fup 0.683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020466 Vd NA 0.9014 L/kg 1compartment NA NA Human Human DTXSID8020466 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020466 TK.Half.Life NA 2.021 hours 1compartment NA NA Human Human -DTXSID8020466 Css NA 0.1748 mg/L 3compartmentss NA 50% Human Human -DTXSID8020466 Css NA 0.7879 mg/L 3compartmentss NA 95% Human Human -DTXSID8020466 Css NA 0.1556 mg/L PBTK NA 50% Human Human -DTXSID8020466 Css NA 0.6129 mg/L PBTK NA 95% Human Human -DTXSID8020466 Clint NA 2.169 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020466 Fup NA 0.9687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020466 Vd NA 1.092 L/kg 1compartment NA NA Rat Human +DTXSID8020466 TK.Half.Life NA 8.696 hours 1compartment NA NA Human Human +DTXSID8020466 Css NA 1.044 mg/L 3compartmentss NA 50% Human Human +DTXSID8020466 Css NA 7.056 mg/L 3compartmentss NA 95% Human Human +DTXSID8020466 Css NA 0.8758 mg/L PBTK NA 50% Human Human +DTXSID8020466 Css NA 4.558 mg/L PBTK NA 95% Human Human +DTXSID8020466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020466 Fup 0.683 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020466 Vd NA 0.8789 L/kg 1compartment NA NA Rat Human DTXSID8020466 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020466 TK.Half.Life NA 1.01 hours 1compartment NA NA Rat Human -DTXSID8020466 Css NA 0.07403 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020466 Css NA 0.2682 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020466 Css NA 0.06632 mg/L PBTK NA 50% Rat Human -DTXSID8020466 Css NA 0.1909 mg/L PBTK NA 95% Rat Human +DTXSID8020466 TK.Half.Life NA 2.849 hours 1compartment NA NA Rat Human +DTXSID8020466 Css NA 0.06262 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020466 Css NA 0.4003 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020466 Css NA 0.05296 mg/L PBTK NA 50% Rat Human +DTXSID8020466 Css NA 0.2485 mg/L PBTK NA 95% Rat Human DTXSID8020468 Clint NA 5.915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020468 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020468 Vd NA 0.7315 L/kg 1compartment NA NA Human Human +DTXSID8020468 Vd NA 0.7348 L/kg 1compartment NA NA Human Human DTXSID8020468 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020468 TK.Half.Life NA 0.7786 hours 1compartment NA NA Human Human -DTXSID8020468 Css NA 0.08144 mg/L 3compartmentss NA 50% Human Human -DTXSID8020468 Css NA 0.7668 mg/L 3compartmentss NA 95% Human Human -DTXSID8020468 Css NA 0.06643 mg/L PBTK NA 50% Human Human -DTXSID8020468 Css NA 0.5497 mg/L PBTK NA 95% Human Human +DTXSID8020468 TK.Half.Life NA 0.7822 hours 1compartment NA NA Human Human +DTXSID8020468 Css NA 0.06391 mg/L 3compartmentss NA 50% Human Human +DTXSID8020468 Css NA 0.6436 mg/L 3compartmentss NA 95% Human Human +DTXSID8020468 Css NA 0.05218 mg/L PBTK NA 50% Human Human +DTXSID8020468 Css NA 0.4507 mg/L PBTK NA 95% Human Human DTXSID8020468 Clint NA 5.915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020468 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020468 Vd NA 0.7741 L/kg 1compartment NA NA Rat Human +DTXSID8020468 Vd NA 0.7769 L/kg 1compartment NA NA Rat Human DTXSID8020468 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020468 TK.Half.Life NA 0.4252 hours 1compartment NA NA Rat Human -DTXSID8020468 Css NA 0.03831 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020468 Css NA 0.2819 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020468 Css NA 0.03108 mg/L PBTK NA 50% Rat Human -DTXSID8020468 Css NA 0.1817 mg/L PBTK NA 95% Rat Human +DTXSID8020468 TK.Half.Life NA 0.4268 hours 1compartment NA NA Rat Human +DTXSID8020468 Css NA 0.002134 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020468 Css NA 0.02372 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020468 Css NA 0.00174 mg/L PBTK NA 50% Rat Human +DTXSID8020468 Css NA 0.01645 mg/L PBTK NA 95% Rat Human DTXSID8020541 Clint 0.8178 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8020541 Fup 0.1624 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8020541 Vd NA 1.359 L/kg 1compartment NA NA Human Human DTXSID8020541 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID8020541 TK.Half.Life NA 27.66 hours 1compartment NA NA Human Human -DTXSID8020541 Css NA 2.161 mg/L 3compartmentss NA 50% Human Human -DTXSID8020541 Css NA 9.833 mg/L 3compartmentss NA 95% Human Human -DTXSID8020541 Css NA 1.759 mg/L PBTK NA 50% Human Human -DTXSID8020541 Css NA 6.753 mg/L PBTK NA 95% Human Human +DTXSID8020541 Css NA 1.948 mg/L 3compartmentss NA 50% Human Human +DTXSID8020541 Css NA 7.436 mg/L 3compartmentss NA 95% Human Human +DTXSID8020541 Css NA 1.726 mg/L PBTK NA 50% Human Human +DTXSID8020541 Css NA 6.598 mg/L PBTK NA 95% Human Human DTXSID8020541 Clint 17.08 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8020541 Fup 0.1305 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID8020541 Vd NA 0.9556 L/kg 1compartment NA NA Rat Rat +DTXSID8020541 Vd 0.029 0.9556 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID8020541 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8020541 TK.Half.Life NA 1.244 hours 1compartment NA NA Rat Rat -DTXSID8020541 Css NA 0.1285 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8020541 Css NA 0.7847 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8020541 Css NA 0.09942 mg/L PBTK NA 50% Rat Rat -DTXSID8020541 Css NA 0.52 mg/L PBTK NA 95% Rat Rat -DTXSID8020543 Clint NA 0.6701 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020543 Fup NA 0.2029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020543 Vd NA 0.45 L/kg 1compartment NA NA Human Human +DTXSID8020541 TK.Half.Life 0.019 1.244 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID8020541 Css 0.038 0.02479 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID8020541 Css 0.038 0.1404 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID8020541 Css 0.038 0.02278 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID8020541 Css 0.038 0.129 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID8020543 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020543 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020543 Vd NA 0.7638 L/kg 1compartment NA NA Human Human DTXSID8020543 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020543 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human -DTXSID8020543 Css NA 1.756 mg/L 3compartmentss NA 50% Human Human -DTXSID8020543 Css NA 7.165 mg/L 3compartmentss NA 95% Human Human -DTXSID8020543 Css NA 1.229 mg/L PBTK NA 50% Human Human -DTXSID8020543 Css NA 4.522 mg/L PBTK NA 95% Human Human -DTXSID8020543 Clint NA 0.6701 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020543 Fup NA 0.2029 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020543 Vd NA 0.4449 L/kg 1compartment NA NA Rat Human +DTXSID8020543 TK.Half.Life NA 1.615 hours 1compartment NA NA Human Human +DTXSID8020543 Css NA 0.1387 mg/L 3compartmentss NA 50% Human Human +DTXSID8020543 Css NA 0.9776 mg/L 3compartmentss NA 95% Human Human +DTXSID8020543 Css NA 0.1132 mg/L PBTK NA 50% Human Human +DTXSID8020543 Css NA 0.6988 mg/L PBTK NA 95% Human Human +DTXSID8020543 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020543 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020543 Vd NA 0.7646 L/kg 1compartment NA NA Rat Human DTXSID8020543 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020543 TK.Half.Life NA 3.162 hours 1compartment NA NA Rat Human -DTXSID8020543 Css NA 0.6744 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020543 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020543 Css NA 0.4479 mg/L PBTK NA 50% Rat Human -DTXSID8020543 Css NA 1.33 mg/L PBTK NA 95% Rat Human +DTXSID8020543 TK.Half.Life NA 0.9206 hours 1compartment NA NA Rat Human +DTXSID8020543 Css NA 0.006024 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020543 Css NA 0.04617 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020543 Css NA 0.004995 mg/L PBTK NA 50% Rat Human +DTXSID8020543 Css NA 0.03204 mg/L PBTK NA 95% Rat Human DTXSID8020545 Clint NA 4.582 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020545 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020545 Vd NA 0.5573 L/kg 1compartment NA NA Human Human +DTXSID8020545 Vd NA 0.5672 L/kg 1compartment NA NA Human Human DTXSID8020545 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020545 TK.Half.Life NA 0.6897 hours 1compartment NA NA Human Human -DTXSID8020545 Css NA 0.1101 mg/L 3compartmentss NA 50% Human Human -DTXSID8020545 Css NA 0.9477 mg/L 3compartmentss NA 95% Human Human -DTXSID8020545 Css NA 0.0831 mg/L PBTK NA 50% Human Human -DTXSID8020545 Css NA 0.641 mg/L PBTK NA 95% Human Human +DTXSID8020545 TK.Half.Life NA 0.7011 hours 1compartment NA NA Human Human +DTXSID8020545 Css NA 0.08688 mg/L 3compartmentss NA 50% Human Human +DTXSID8020545 Css NA 0.8317 mg/L 3compartmentss NA 95% Human Human +DTXSID8020545 Css NA 0.06644 mg/L PBTK NA 50% Human Human +DTXSID8020545 Css NA 0.5426 mg/L PBTK NA 95% Human Human DTXSID8020545 Clint NA 4.582 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020545 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020545 Vd NA 0.5769 L/kg 1compartment NA NA Rat Human +DTXSID8020545 Vd NA 0.5858 L/kg 1compartment NA NA Rat Human DTXSID8020545 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020545 TK.Half.Life NA 0.3671 hours 1compartment NA NA Rat Human -DTXSID8020545 Css NA 0.05103 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020545 Css NA 0.3423 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020545 Css NA 0.03804 mg/L PBTK NA 50% Rat Human -DTXSID8020545 Css NA 0.2099 mg/L PBTK NA 95% Rat Human -DTXSID8020591 Clint NA 42.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020591 Fup NA 0.1544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020591 Vd NA 1.548 L/kg 1compartment NA NA Human Human +DTXSID8020545 TK.Half.Life NA 0.3725 hours 1compartment NA NA Rat Human +DTXSID8020545 Css NA 0.002868 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020545 Css NA 0.02915 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020545 Css NA 0.002161 mg/L PBTK NA 50% Rat Human +DTXSID8020545 Css NA 0.01943 mg/L PBTK NA 95% Rat Human +DTXSID8020591 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020591 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020591 Vd NA 1.842 L/kg 1compartment NA NA Human Human DTXSID8020591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020591 TK.Half.Life NA 2.297 hours 1compartment NA NA Human Human -DTXSID8020591 Css NA 0.09787 mg/L 3compartmentss NA 50% Human Human -DTXSID8020591 Css NA 0.7596 mg/L 3compartmentss NA 95% Human Human -DTXSID8020591 Css NA 0.06729 mg/L PBTK NA 50% Human Human -DTXSID8020591 Css NA 0.4919 mg/L PBTK NA 95% Human Human -DTXSID8020591 Clint NA 42.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020591 Fup NA 0.1544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020591 Vd NA 1.203 L/kg 1compartment NA NA Rat Human +DTXSID8020591 TK.Half.Life NA 3.533 hours 1compartment NA NA Human Human +DTXSID8020591 Css NA 0.1397 mg/L 3compartmentss NA 50% Human Human +DTXSID8020591 Css NA 0.9193 mg/L 3compartmentss NA 95% Human Human +DTXSID8020591 Css NA 0.1013 mg/L PBTK NA 50% Human Human +DTXSID8020591 Css NA 0.6199 mg/L PBTK NA 95% Human Human +DTXSID8020591 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020591 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020591 Vd NA 1.43 L/kg 1compartment NA NA Rat Human DTXSID8020591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020591 TK.Half.Life NA 0.8614 hours 1compartment NA NA Rat Human -DTXSID8020591 Css NA 0.05538 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020591 Css NA 0.3293 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020591 Css NA 0.03632 mg/L PBTK NA 50% Rat Human -DTXSID8020591 Css NA 0.2012 mg/L PBTK NA 95% Rat Human +DTXSID8020591 TK.Half.Life NA 1.266 hours 1compartment NA NA Rat Human +DTXSID8020591 Css NA 0.01759 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020591 Css NA 0.08839 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020591 Css NA 0.0127 mg/L PBTK NA 50% Rat Human +DTXSID8020591 Css NA 0.0607 mg/L PBTK NA 95% Rat Human DTXSID8020593 Clint NA 0.009632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020593 Fup NA 0.9936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020593 Vd NA 0.8589 L/kg 1compartment NA NA Human Human DTXSID8020593 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8020593 TK.Half.Life NA 5.55 hours 1compartment NA NA Human Human -DTXSID8020593 Css NA 0.8436 mg/L 3compartmentss NA 50% Human Human -DTXSID8020593 Css NA 4.724 mg/L 3compartmentss NA 95% Human Human -DTXSID8020593 Css NA 0.709 mg/L PBTK NA 50% Human Human -DTXSID8020593 Css NA 3.137 mg/L PBTK NA 95% Human Human +DTXSID8020593 Css NA 0.722 mg/L 3compartmentss NA 50% Human Human +DTXSID8020593 Css NA 4.155 mg/L 3compartmentss NA 95% Human Human +DTXSID8020593 Css NA 0.606 mg/L PBTK NA 50% Human Human +DTXSID8020593 Css NA 2.753 mg/L PBTK NA 95% Human Human DTXSID8020593 Clint NA 0.009632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020593 Fup NA 0.9936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020593 Vd NA 0.8639 L/kg 1compartment NA NA Rat Human DTXSID8020593 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8020593 TK.Half.Life NA 1.906 hours 1compartment NA NA Rat Human -DTXSID8020593 Css NA 0.2162 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020593 Css NA 1.272 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020593 Css NA 0.1777 mg/L PBTK NA 50% Rat Human -DTXSID8020593 Css NA 0.77 mg/L PBTK NA 95% Rat Human +DTXSID8020593 Css NA 0.01378 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020593 Css NA 0.1031 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020593 Css NA 0.01122 mg/L PBTK NA 50% Rat Human +DTXSID8020593 Css NA 0.06778 mg/L PBTK NA 95% Rat Human DTXSID8020597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020597 Fup NA 0.7074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020597 Vd NA 0.6168 L/kg 1compartment NA NA Human Human DTXSID8020597 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8020597 TK.Half.Life NA 5.64 hours 1compartment NA NA Human Human -DTXSID8020597 Css NA 1.114 mg/L 3compartmentss NA 50% Human Human -DTXSID8020597 Css NA 7.174 mg/L 3compartmentss NA 95% Human Human -DTXSID8020597 Css NA 0.876 mg/L PBTK NA 50% Human Human -DTXSID8020597 Css NA 4.492 mg/L PBTK NA 95% Human Human +DTXSID8020597 Css NA 0.942 mg/L 3compartmentss NA 50% Human Human +DTXSID8020597 Css NA 6.173 mg/L 3compartmentss NA 95% Human Human +DTXSID8020597 Css NA 0.7422 mg/L PBTK NA 50% Human Human +DTXSID8020597 Css NA 3.879 mg/L PBTK NA 95% Human Human DTXSID8020597 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020597 Fup NA 0.7074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020597 Vd NA 0.6489 L/kg 1compartment NA NA Rat Human DTXSID8020597 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8020597 TK.Half.Life NA 2.023 hours 1compartment NA NA Rat Human -DTXSID8020597 Css NA 0.2872 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020597 Css NA 1.855 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020597 Css NA 0.2188 mg/L PBTK NA 50% Rat Human -DTXSID8020597 Css NA 1.085 mg/L PBTK NA 95% Rat Human +DTXSID8020597 Css NA 0.0181 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020597 Css NA 0.1472 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020597 Css NA 0.01374 mg/L PBTK NA 50% Rat Human +DTXSID8020597 Css NA 0.09277 mg/L PBTK NA 95% Rat Human +DTXSID80206109 Clint 42.89 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human +DTXSID80206109 Fup 0.0937 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80206109 Vd NA 0.3341 L/kg 1compartment NA NA Human Human +DTXSID80206109 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80206109 TK.Half.Life NA 0.6145 hours 1compartment NA NA Human Human +DTXSID80206109 Css NA 0.158 mg/L 3compartmentss NA 50% Human Human +DTXSID80206109 Css NA 1.348 mg/L 3compartmentss NA 95% Human Human +DTXSID80206109 Css NA 0.0963 mg/L PBTK NA 50% Human Human +DTXSID80206109 Css NA 0.8171 mg/L PBTK NA 95% Human Human +DTXSID80206109 Clint 42.89 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human +DTXSID80206109 Fup 0.0937 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80206109 Vd NA 0.305 L/kg 1compartment NA NA Rat Human +DTXSID80206109 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80206109 TK.Half.Life NA 0.3148 hours 1compartment NA NA Rat Human +DTXSID80206109 Css NA 0.02126 mg/L 3compartmentss NA 50% Rat Human +DTXSID80206109 Css NA 0.1401 mg/L 3compartmentss NA 95% Rat Human +DTXSID80206109 Css NA 0.01269 mg/L PBTK NA 50% Rat Human +DTXSID80206109 Css NA 0.0811 mg/L PBTK NA 95% Rat Human DTXSID8020620 Clint 87.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID8020620 Fup NA 0.0244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020620 Vd NA 2.474 L/kg 1compartment NA NA Human Human +DTXSID8020620 Fup 0.0072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020620 Vd NA 1.729 L/kg 1compartment NA NA Human Human DTXSID8020620 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020620 TK.Half.Life NA 8.365 hours 1compartment NA NA Human Human -DTXSID8020620 Css NA 0.3896 mg/L 3compartmentss NA 50% Human Human -DTXSID8020620 Css NA 2.862 mg/L 3compartmentss NA 95% Human Human -DTXSID8020620 Css NA 0.2583 mg/L PBTK NA 50% Human Human -DTXSID8020620 Css NA 1.812 mg/L PBTK NA 95% Human Human +DTXSID8020620 TK.Half.Life NA 9.226 hours 1compartment NA NA Human Human +DTXSID8020620 Css NA 0.7507 mg/L 3compartmentss NA 50% Human Human +DTXSID8020620 Css NA 7.045 mg/L 3compartmentss NA 95% Human Human +DTXSID8020620 Css NA 0.4682 mg/L PBTK NA 50% Human Human +DTXSID8020620 Css NA 4.266 mg/L PBTK NA 95% Human Human DTXSID8020620 Clint 87.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID8020620 Fup NA 0.0244 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020620 Vd NA 1.846 L/kg 1compartment NA NA Rat Human +DTXSID8020620 Fup 0.0072 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020620 Vd NA 1.276 L/kg 1compartment NA NA Rat Human DTXSID8020620 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020620 TK.Half.Life NA 2.242 hours 1compartment NA NA Rat Human -DTXSID8020620 Css NA 0.2178 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020620 Css NA 1.336 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020620 Css NA 0.1367 mg/L PBTK NA 50% Rat Human -DTXSID8020620 Css NA 0.7837 mg/L PBTK NA 95% Rat Human -DTXSID8020622 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020622 Fup NA 0.5819 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020622 Vd NA 0.4756 L/kg 1compartment NA NA Human Human -DTXSID8020622 TK.Half.Life NA NA hours 1compartment NA NA Human Human -DTXSID8020622 Css NA NA mg/L 3compartmentss NA 50% Human Human -DTXSID8020622 Css NA NA mg/L 3compartmentss NA 95% Human Human -DTXSID8020622 Css NA NA mg/L PBTK NA 50% Human Human -DTXSID8020622 Css NA NA mg/L PBTK NA 95% Human Human -DTXSID8020622 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020622 Fup NA 0.5819 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020622 Vd NA 0.5189 L/kg 1compartment NA NA Rat Human -DTXSID8020622 TK.Half.Life NA NA hours 1compartment NA NA Rat Human -DTXSID8020622 Css NA NA mg/L 3compartmentss NA 50% Rat Human -DTXSID8020622 Css NA NA mg/L 3compartmentss NA 95% Rat Human -DTXSID8020622 Css NA NA mg/L PBTK NA 50% Rat Human -DTXSID8020622 Css NA NA mg/L PBTK NA 95% Rat Human +DTXSID8020620 TK.Half.Life NA 1.501 hours 1compartment NA NA Rat Human +DTXSID8020620 Css NA 0.03568 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020620 Css NA 0.2713 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020620 Css NA 0.02169 mg/L PBTK NA 50% Rat Human +DTXSID8020620 Css NA 0.1591 mg/L PBTK NA 95% Rat Human DTXSID8020624 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020624 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020624 Vd NA 0.4732 L/kg 1compartment NA NA Human Human +DTXSID8020624 Vd NA 0.3524 L/kg 1compartment NA NA Human Human DTXSID8020624 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020624 TK.Half.Life NA 5.986 hours 1compartment NA NA Human Human -DTXSID8020624 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human -DTXSID8020624 Css NA 7.282 mg/L 3compartmentss NA 95% Human Human -DTXSID8020624 Css NA 1.074 mg/L PBTK NA 50% Human Human -DTXSID8020624 Css NA 4.538 mg/L PBTK NA 95% Human Human +DTXSID8020624 TK.Half.Life NA 4.376 hours 1compartment NA NA Human Human +DTXSID8020624 Css NA 1.273 mg/L 3compartmentss NA 50% Human Human +DTXSID8020624 Css NA 6.321 mg/L 3compartmentss NA 95% Human Human +DTXSID8020624 Css NA 0.889 mg/L PBTK NA 50% Human Human +DTXSID8020624 Css NA 3.895 mg/L PBTK NA 95% Human Human DTXSID8020624 Clint NA 0.03006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020624 Fup NA 0.4882 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020624 Vd NA 0.4747 L/kg 1compartment NA NA Rat Human +DTXSID8020624 Vd NA 0.371 L/kg 1compartment NA NA Rat Human DTXSID8020624 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020624 TK.Half.Life NA 2.095 hours 1compartment NA NA Rat Human -DTXSID8020624 Css NA 0.4147 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020624 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020624 Css NA 0.285 mg/L PBTK NA 50% Rat Human -DTXSID8020624 Css NA 1.07 mg/L PBTK NA 95% Rat Human -DTXSID8020626 Clint NA 218.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020626 Fup NA 0.2096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020626 Vd NA 3.529 L/kg 1compartment NA NA Human Human +DTXSID8020624 TK.Half.Life NA 1.623 hours 1compartment NA NA Rat Human +DTXSID8020624 Css NA 0.02472 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020624 Css NA 0.1699 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020624 Css NA 0.01664 mg/L PBTK NA 50% Rat Human +DTXSID8020624 Css NA 0.103 mg/L PBTK NA 95% Rat Human +DTXSID8020626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020626 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020626 Vd NA 1.219 L/kg 1compartment NA NA Human Human DTXSID8020626 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020626 TK.Half.Life NA 2.784 hours 1compartment NA NA Human Human -DTXSID8020626 Css NA 0.01582 mg/L 3compartmentss NA 50% Human Human -DTXSID8020626 Css NA 0.1066 mg/L 3compartmentss NA 95% Human Human -DTXSID8020626 Css NA 0.01368 mg/L PBTK NA 50% Human Human -DTXSID8020626 Css NA 0.0841 mg/L PBTK NA 95% Human Human -DTXSID8020626 Clint NA 218.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020626 Fup NA 0.2096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020626 Vd NA 3.002 L/kg 1compartment NA NA Rat Human +DTXSID8020626 TK.Half.Life NA 2.116 hours 1compartment NA NA Human Human +DTXSID8020626 Css NA 0.1164 mg/L 3compartmentss NA 50% Human Human +DTXSID8020626 Css NA 0.876 mg/L 3compartmentss NA 95% Human Human +DTXSID8020626 Css NA 0.08621 mg/L PBTK NA 50% Human Human +DTXSID8020626 Css NA 0.6013 mg/L PBTK NA 95% Human Human +DTXSID8020626 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020626 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020626 Vd NA 1.206 L/kg 1compartment NA NA Rat Human DTXSID8020626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020626 TK.Half.Life NA 0.9764 hours 1compartment NA NA Rat Human -DTXSID8020626 Css NA 0.008601 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020626 Css NA 0.05098 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020626 Css NA 0.007303 mg/L PBTK NA 50% Rat Human -DTXSID8020626 Css NA 0.04016 mg/L PBTK NA 95% Rat Human +DTXSID8020626 TK.Half.Life NA 1.195 hours 1compartment NA NA Rat Human +DTXSID8020626 Css NA 0.01489 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020626 Css NA 0.08319 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020626 Css NA 0.01102 mg/L PBTK NA 50% Rat Human +DTXSID8020626 Css NA 0.05693 mg/L PBTK NA 95% Rat Human DTXSID8020628 Clint 10.06 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8020628 Fup 0.2589 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8020628 Vd NA 1.777 L/kg 1compartment NA NA Human Human DTXSID8020628 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8020628 TK.Half.Life NA 4.548 hours 1compartment NA NA Human Human -DTXSID8020628 Css NA 0.2241 mg/L 3compartmentss NA 50% Human Human -DTXSID8020628 Css NA 1.389 mg/L 3compartmentss NA 95% Human Human -DTXSID8020628 Css NA 0.1668 mg/L PBTK NA 50% Human Human -DTXSID8020628 Css NA 0.9556 mg/L PBTK NA 95% Human Human +DTXSID8020628 Css NA 0.218 mg/L 3compartmentss NA 50% Human Human +DTXSID8020628 Css NA 1.351 mg/L 3compartmentss NA 95% Human Human +DTXSID8020628 Css NA 0.1626 mg/L PBTK NA 50% Human Human +DTXSID8020628 Css NA 0.9359 mg/L PBTK NA 95% Human Human DTXSID8020628 Clint 10.06 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8020628 Fup 0.2589 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8020628 Vd NA 1.4 L/kg 1compartment NA NA Rat Human DTXSID8020628 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8020628 TK.Half.Life NA 1.683 hours 1compartment NA NA Rat Human -DTXSID8020628 Css NA 0.1186 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020628 Css NA 0.5343 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020628 Css NA 0.085 mg/L PBTK NA 50% Rat Human -DTXSID8020628 Css NA 0.3549 mg/L PBTK NA 95% Rat Human -DTXSID8020674 Clint NA 15.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020674 Fup NA 0.1171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020674 Vd NA 0.9807 L/kg 1compartment NA NA Human Human +DTXSID8020628 Css NA 0.0266 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020628 Css NA 0.1228 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020628 Css NA 0.01968 mg/L PBTK NA 50% Rat Human +DTXSID8020628 Css NA 0.08316 mg/L PBTK NA 95% Rat Human +DTXSID8020674 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020674 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020674 Vd NA 1.211 L/kg 1compartment NA NA Human Human DTXSID8020674 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020674 TK.Half.Life NA 2.899 hours 1compartment NA NA Human Human -DTXSID8020674 Css NA 0.3428 mg/L 3compartmentss NA 50% Human Human -DTXSID8020674 Css NA 2.6 mg/L 3compartmentss NA 95% Human Human -DTXSID8020674 Css NA 0.2238 mg/L PBTK NA 50% Human Human -DTXSID8020674 Css NA 1.587 mg/L PBTK NA 95% Human Human -DTXSID8020674 Clint NA 15.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020674 Fup NA 0.1171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020674 Vd NA 0.7807 L/kg 1compartment NA NA Rat Human +DTXSID8020674 TK.Half.Life NA 5.134 hours 1compartment NA NA Human Human +DTXSID8020674 Css NA 0.4292 mg/L 3compartmentss NA 50% Human Human +DTXSID8020674 Css NA 2.447 mg/L 3compartmentss NA 95% Human Human +DTXSID8020674 Css NA 0.3014 mg/L PBTK NA 50% Human Human +DTXSID8020674 Css NA 1.58 mg/L PBTK NA 95% Human Human +DTXSID8020674 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020674 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020674 Vd NA 0.9677 L/kg 1compartment NA NA Rat Human DTXSID8020674 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020674 TK.Half.Life NA 1.296 hours 1compartment NA NA Rat Human -DTXSID8020674 Css NA 0.1884 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020674 Css NA 1.095 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020674 Css NA 0.1166 mg/L PBTK NA 50% Rat Human -DTXSID8020674 Css NA 0.6299 mg/L PBTK NA 95% Rat Human -DTXSID8020678 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020678 Fup NA 0.1362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020678 Vd NA 0.5622 L/kg 1compartment NA NA Human Human -DTXSID8020678 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8020678 TK.Half.Life NA 27.39 hours 1compartment NA NA Human Human -DTXSID8020678 Css NA 7.028 mg/L 3compartmentss NA 50% Human Human -DTXSID8020678 Css NA 32.05 mg/L 3compartmentss NA 95% Human Human -DTXSID8020678 Css NA 4.559 mg/L PBTK NA 50% Human Human -DTXSID8020678 Css NA 19.06 mg/L PBTK NA 95% Human Human -DTXSID8020678 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020678 Fup NA 0.1362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020678 Vd NA 0.4939 L/kg 1compartment NA NA Rat Human +DTXSID8020674 TK.Half.Life NA 2.195 hours 1compartment NA NA Rat Human +DTXSID8020674 Css NA 0.05162 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020674 Css NA 0.2155 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020674 Css NA 0.0357 mg/L PBTK NA 50% Rat Human +DTXSID8020674 Css NA 0.1368 mg/L PBTK NA 95% Rat Human +DTXSID8020678 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020678 Fup 0.205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020678 Vd NA 0.4177 L/kg 1compartment NA NA Human Human +DTXSID8020678 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8020678 TK.Half.Life NA 1.453 hours 1compartment NA NA Human Human +DTXSID8020678 Css NA 0.3506 mg/L 3compartmentss NA 50% Human Human +DTXSID8020678 Css NA 2.06 mg/L 3compartmentss NA 95% Human Human +DTXSID8020678 Css NA 0.2302 mg/L PBTK NA 50% Human Human +DTXSID8020678 Css NA 1.284 mg/L PBTK NA 95% Human Human +DTXSID8020678 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020678 Fup 0.205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020678 Vd NA 0.4119 L/kg 1compartment NA NA Rat Human DTXSID8020678 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020678 TK.Half.Life NA 8.042 hours 1compartment NA NA Rat Human -DTXSID8020678 Css NA 1.97 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020678 Css NA 7.691 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020678 Css NA 1.195 mg/L PBTK NA 50% Rat Human -DTXSID8020678 Css NA 4.296 mg/L PBTK NA 95% Rat Human -DTXSID8020703 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020703 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020703 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID8020703 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020703 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID8020703 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID8020703 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID8020703 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID8020703 Css NA 5.926 mg/L PBTK NA 95% Human Human -DTXSID8020703 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020703 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020703 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human -DTXSID8020703 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020703 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID8020703 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020703 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020703 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID8020703 Css NA 1.296 mg/L PBTK NA 95% Rat Human -DTXSID8020707 Clint NA 52.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020707 Fup NA 0.1564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020707 Vd NA 0.978 L/kg 1compartment NA NA Human Human +DTXSID8020678 TK.Half.Life NA 0.839 hours 1compartment NA NA Rat Human +DTXSID8020678 Css NA 0.0419 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020678 Css NA 0.1742 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020678 Css NA 0.02725 mg/L PBTK NA 50% Rat Human +DTXSID8020678 Css NA 0.1065 mg/L PBTK NA 95% Rat Human +DTXSID8020707 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020707 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020707 Vd NA 1.013 L/kg 1compartment NA NA Human Human DTXSID8020707 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020707 TK.Half.Life NA 1.265 hours 1compartment NA NA Human Human -DTXSID8020707 Css NA 0.07048 mg/L 3compartmentss NA 50% Human Human -DTXSID8020707 Css NA 0.5838 mg/L 3compartmentss NA 95% Human Human -DTXSID8020707 Css NA 0.04763 mg/L PBTK NA 50% Human Human -DTXSID8020707 Css NA 0.3745 mg/L PBTK NA 95% Human Human -DTXSID8020707 Clint NA 52.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020707 Fup NA 0.1564 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020707 Vd NA 0.7947 L/kg 1compartment NA NA Rat Human +DTXSID8020707 TK.Half.Life NA 2.022 hours 1compartment NA NA Human Human +DTXSID8020707 Css NA 0.1703 mg/L 3compartmentss NA 50% Human Human +DTXSID8020707 Css NA 1.289 mg/L 3compartmentss NA 95% Human Human +DTXSID8020707 Css NA 0.114 mg/L PBTK NA 50% Human Human +DTXSID8020707 Css NA 0.8253 mg/L PBTK NA 95% Human Human +DTXSID8020707 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020707 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020707 Vd NA 0.8177 L/kg 1compartment NA NA Rat Human DTXSID8020707 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020707 TK.Half.Life NA 0.5212 hours 1compartment NA NA Rat Human -DTXSID8020707 Css NA 0.03946 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020707 Css NA 0.2614 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020707 Css NA 0.02531 mg/L PBTK NA 50% Rat Human -DTXSID8020707 Css NA 0.1555 mg/L PBTK NA 95% Rat Human -DTXSID8020709 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020709 Fup NA 0.2666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020709 Vd NA 0.279 L/kg 1compartment NA NA Human Human +DTXSID8020707 TK.Half.Life NA 0.8841 hours 1compartment NA NA Rat Human +DTXSID8020707 Css NA 0.022 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020707 Css NA 0.1355 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020707 Css NA 0.01453 mg/L PBTK NA 50% Rat Human +DTXSID8020707 Css NA 0.08287 mg/L PBTK NA 95% Rat Human +DTXSID8020709 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020709 Fup 0.522 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020709 Vd NA 0.3689 L/kg 1compartment NA NA Human Human DTXSID8020709 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020709 TK.Half.Life NA 6.769 hours 1compartment NA NA Human Human -DTXSID8020709 Css NA 3.077 mg/L 3compartmentss NA 50% Human Human -DTXSID8020709 Css NA 11.62 mg/L 3compartmentss NA 95% Human Human -DTXSID8020709 Css NA 1.976 mg/L PBTK NA 50% Human Human -DTXSID8020709 Css NA 6.96 mg/L PBTK NA 95% Human Human -DTXSID8020709 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020709 Fup NA 0.2666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020709 Vd NA 0.2869 L/kg 1compartment NA NA Rat Human +DTXSID8020709 TK.Half.Life NA 0.3881 hours 1compartment NA NA Human Human +DTXSID8020709 Css NA 0.04058 mg/L 3compartmentss NA 50% Human Human +DTXSID8020709 Css NA 0.3494 mg/L 3compartmentss NA 95% Human Human +DTXSID8020709 Css NA 0.028 mg/L PBTK NA 50% Human Human +DTXSID8020709 Css NA 0.2237 mg/L PBTK NA 95% Human Human +DTXSID8020709 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020709 Fup 0.522 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020709 Vd NA 0.3832 L/kg 1compartment NA NA Rat Human DTXSID8020709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020709 TK.Half.Life NA 2.373 hours 1compartment NA NA Rat Human -DTXSID8020709 Css NA 0.8646 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020709 Css NA 2.639 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020709 Css NA 0.5224 mg/L PBTK NA 50% Rat Human -DTXSID8020709 Css NA 1.485 mg/L PBTK NA 95% Rat Human +DTXSID8020709 TK.Half.Life NA 0.1992 hours 1compartment NA NA Rat Human +DTXSID8020709 Css NA 0.005087 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020709 Css NA 0.03799 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020709 Css NA 0.00349 mg/L PBTK NA 50% Rat Human +DTXSID8020709 Css NA 0.02343 mg/L PBTK NA 95% Rat Human DTXSID8020753 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020753 Fup NA 0.886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020753 Vd NA 0.6362 L/kg 1compartment NA NA Human Human +DTXSID8020753 Vd NA 0.6358 L/kg 1compartment NA NA Human Human DTXSID8020753 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020753 TK.Half.Life NA 4.646 hours 1compartment NA NA Human Human -DTXSID8020753 Css NA 0.9618 mg/L 3compartmentss NA 50% Human Human -DTXSID8020753 Css NA 5.172 mg/L 3compartmentss NA 95% Human Human -DTXSID8020753 Css NA 0.775 mg/L PBTK NA 50% Human Human -DTXSID8020753 Css NA 3.319 mg/L PBTK NA 95% Human Human +DTXSID8020753 TK.Half.Life NA 4.643 hours 1compartment NA NA Human Human +DTXSID8020753 Css NA 0.8246 mg/L 3compartmentss NA 50% Human Human +DTXSID8020753 Css NA 4.462 mg/L 3compartmentss NA 95% Human Human +DTXSID8020753 Css NA 0.6588 mg/L PBTK NA 50% Human Human +DTXSID8020753 Css NA 2.89 mg/L PBTK NA 95% Human Human DTXSID8020753 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020753 Fup NA 0.886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020753 Vd NA 0.6859 L/kg 1compartment NA NA Rat Human +DTXSID8020753 Vd NA 0.6855 L/kg 1compartment NA NA Rat Human DTXSID8020753 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020753 TK.Half.Life NA 1.707 hours 1compartment NA NA Rat Human -DTXSID8020753 Css NA 0.2456 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020753 Css NA 1.374 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020753 Css NA 0.1909 mg/L PBTK NA 50% Rat Human -DTXSID8020753 Css NA 0.8183 mg/L PBTK NA 95% Rat Human +DTXSID8020753 TK.Half.Life NA 1.706 hours 1compartment NA NA Rat Human +DTXSID8020753 Css NA 0.01527 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020753 Css NA 0.1078 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020753 Css NA 0.01174 mg/L PBTK NA 50% Rat Human +DTXSID8020753 Css NA 0.07024 mg/L PBTK NA 95% Rat Human DTXSID8020755 Clint 1.11 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID8020755 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8020755 Vd NA 0.8569 L/kg 1compartment NA NA Human Human DTXSID8020755 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8020755 TK.Half.Life NA 2.158 hours 1compartment NA NA Human Human -DTXSID8020755 Css NA 0.294 mg/L 3compartmentss NA 50% Human Human -DTXSID8020755 Css NA 2.087 mg/L 3compartmentss NA 95% Human Human -DTXSID8020755 Css NA 0.2495 mg/L PBTK NA 50% Human Human -DTXSID8020755 Css NA 1.405 mg/L PBTK NA 95% Human Human +DTXSID8020755 Css NA 0.2815 mg/L 3compartmentss NA 50% Human Human +DTXSID8020755 Css NA 1.873 mg/L 3compartmentss NA 95% Human Human +DTXSID8020755 Css NA 0.2395 mg/L PBTK NA 50% Human Human +DTXSID8020755 Css NA 1.286 mg/L PBTK NA 95% Human Human DTXSID8020755 Clint 1.11 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID8020755 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8020755 Vd NA 0.8881 L/kg 1compartment NA NA Rat Human DTXSID8020755 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8020755 TK.Half.Life NA 1.084 hours 1compartment NA NA Rat Human -DTXSID8020755 Css NA 0.1103 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020755 Css NA 0.7203 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020755 Css NA 0.09314 mg/L PBTK NA 50% Rat Human -DTXSID8020755 Css NA 0.4328 mg/L PBTK NA 95% Rat Human -DTXSID8020757 Clint NA 0.006044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020757 Fup NA 0.3891 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020757 Vd NA 0.4027 L/kg 1compartment NA NA Human Human +DTXSID8020755 Css NA 0.02459 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020755 Css NA 0.1581 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020755 Css NA 0.02154 mg/L PBTK NA 50% Rat Human +DTXSID8020755 Css NA 0.09877 mg/L PBTK NA 95% Rat Human +DTXSID8020757 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020757 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020757 Vd NA 0.6388 L/kg 1compartment NA NA Human Human DTXSID8020757 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020757 TK.Half.Life NA 6.627 hours 1compartment NA NA Human Human -DTXSID8020757 Css NA 1.924 mg/L 3compartmentss NA 50% Human Human -DTXSID8020757 Css NA 8.267 mg/L 3compartmentss NA 95% Human Human -DTXSID8020757 Css NA 1.352 mg/L PBTK NA 50% Human Human -DTXSID8020757 Css NA 5.137 mg/L PBTK NA 95% Human Human -DTXSID8020757 Clint NA 0.006044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020757 Fup NA 0.3891 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020757 Vd NA 0.4113 L/kg 1compartment NA NA Rat Human +DTXSID8020757 TK.Half.Life NA 0.58 hours 1compartment NA NA Human Human +DTXSID8020757 Css NA 0.03234 mg/L 3compartmentss NA 50% Human Human +DTXSID8020757 Css NA 0.3492 mg/L 3compartmentss NA 95% Human Human +DTXSID8020757 Css NA 0.02546 mg/L PBTK NA 50% Human Human +DTXSID8020757 Css NA 0.2332 mg/L PBTK NA 95% Human Human +DTXSID8020757 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020757 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020757 Vd NA 0.6561 L/kg 1compartment NA NA Rat Human DTXSID8020757 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020757 TK.Half.Life NA 2.32 hours 1compartment NA NA Rat Human -DTXSID8020757 Css NA 0.5376 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020757 Css NA 1.946 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020757 Css NA 0.3589 mg/L PBTK NA 50% Rat Human -DTXSID8020757 Css NA 1.13 mg/L PBTK NA 95% Rat Human +DTXSID8020757 TK.Half.Life NA 0.2955 hours 1compartment NA NA Rat Human +DTXSID8020757 Css NA 0.00396 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020757 Css NA 0.0379 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020757 Css NA 0.003138 mg/L PBTK NA 50% Rat Human +DTXSID8020757 Css NA 0.02467 mg/L PBTK NA 95% Rat Human +DTXSID8020759 Clint 18.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID8020759 Fup NA 0.5319 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8020759 Vd NA 1.477 L/kg 1compartment NA NA Human Human +DTXSID8020759 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8020759 TK.Half.Life NA 1.515 hours 1compartment NA NA Human Human +DTXSID8020759 Css NA 0.04592 mg/L 3compartmentss NA 50% Human Human +DTXSID8020759 Css NA 0.468 mg/L 3compartmentss NA 95% Human Human +DTXSID8020759 Css NA 0.03846 mg/L PBTK NA 50% Human Human +DTXSID8020759 Css NA 0.3337 mg/L PBTK NA 95% Human Human +DTXSID8020759 Clint 19.3 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat +DTXSID8020759 Fup 0.561 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat +DTXSID8020759 Vd NA 1.296 L/kg 1compartment NA NA Rat Rat +DTXSID8020759 Days.Css NA 0 Days PBTK NA NA Rat Rat +DTXSID8020759 TK.Half.Life NA 0.6161 hours 1compartment NA NA Rat Rat +DTXSID8020759 Css NA 0.005074 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8020759 Css NA 0.04354 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8020759 Css NA 0.004371 mg/L PBTK NA 50% Rat Rat +DTXSID8020759 Css NA 0.02976 mg/L PBTK NA 95% Rat Rat DTXSID8020830 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8020830 Fup 0.09 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID8020830 Vd NA 0.6668 L/kg 1compartment NA NA Human Human -DTXSID8020830 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID8020830 TK.Half.Life NA 50.52 hours 1compartment NA NA Human Human -DTXSID8020830 Css NA 11.02 mg/L 3compartmentss NA 50% Human Human -DTXSID8020830 Css NA 51.12 mg/L 3compartmentss NA 95% Human Human -DTXSID8020830 Css NA 7.302 mg/L PBTK NA 50% Human Human -DTXSID8020830 Css NA 30.76 mg/L PBTK NA 95% Human Human +DTXSID8020830 Vd NA 0.8244 L/kg 1compartment NA NA Human Human +DTXSID8020830 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID8020830 TK.Half.Life NA 64.84 hours 1compartment NA NA Human Human +DTXSID8020830 Css NA 10.94 mg/L 3compartmentss NA 50% Human Human +DTXSID8020830 Css NA 45.63 mg/L 3compartmentss NA 95% Human Human +DTXSID8020830 Css NA 7.329 mg/L PBTK NA 50% Human Human +DTXSID8020830 Css NA 30.57 mg/L PBTK NA 95% Human Human DTXSID8020830 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID8020830 Fup 0.09 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human -DTXSID8020830 Vd NA 0.5455 L/kg 1compartment NA NA Rat Human -DTXSID8020830 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8020830 TK.Half.Life NA 13.53 hours 1compartment NA NA Rat Human -DTXSID8020830 Css NA 3.125 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020830 Css NA 12.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020830 Css NA 1.958 mg/L PBTK NA 50% Rat Human -DTXSID8020830 Css NA 6.962 mg/L PBTK NA 95% Rat Human +DTXSID8020830 Vd NA 0.6539 L/kg 1compartment NA NA Rat Human +DTXSID8020830 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8020830 TK.Half.Life NA 16.38 hours 1compartment NA NA Rat Human +DTXSID8020830 Css NA 0.6792 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020830 Css NA 2.328 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020830 Css NA 0.4714 mg/L PBTK NA 50% Rat Human +DTXSID8020830 Css NA 1.616 mg/L PBTK NA 95% Rat Human DTXSID8020834 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020834 Fup NA 0.7932 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8020834 Vd NA 0.7152 L/kg 1compartment NA NA Human Human DTXSID8020834 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8020834 TK.Half.Life NA 5.839 hours 1compartment NA NA Human Human -DTXSID8020834 Css NA 1.003 mg/L 3compartmentss NA 50% Human Human -DTXSID8020834 Css NA 6.023 mg/L 3compartmentss NA 95% Human Human -DTXSID8020834 Css NA 0.8223 mg/L PBTK NA 50% Human Human -DTXSID8020834 Css NA 3.906 mg/L PBTK NA 95% Human Human +DTXSID8020834 Css NA 0.8511 mg/L 3compartmentss NA 50% Human Human +DTXSID8020834 Css NA 5.363 mg/L 3compartmentss NA 95% Human Human +DTXSID8020834 Css NA 0.6981 mg/L PBTK NA 50% Human Human +DTXSID8020834 Css NA 3.43 mg/L PBTK NA 95% Human Human DTXSID8020834 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020834 Fup NA 0.7932 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8020834 Vd NA 0.7412 L/kg 1compartment NA NA Rat Human DTXSID8020834 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8020834 TK.Half.Life NA 2.061 hours 1compartment NA NA Rat Human -DTXSID8020834 Css NA 0.2561 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020834 Css NA 1.564 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020834 Css NA 0.203 mg/L PBTK NA 50% Rat Human -DTXSID8020834 Css NA 0.9308 mg/L PBTK NA 95% Rat Human -DTXSID8020838 Clint NA 31.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020838 Fup NA 0.0363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020838 Vd NA 2.032 L/kg 1compartment NA NA Human Human -DTXSID8020838 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020838 TK.Half.Life NA 10.27 hours 1compartment NA NA Human Human -DTXSID8020838 Css NA 0.6874 mg/L 3compartmentss NA 50% Human Human -DTXSID8020838 Css NA 5.228 mg/L 3compartmentss NA 95% Human Human -DTXSID8020838 Css NA 0.4464 mg/L PBTK NA 50% Human Human -DTXSID8020838 Css NA 3.287 mg/L PBTK NA 95% Human Human -DTXSID8020838 Clint NA 31.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020838 Fup NA 0.0363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020838 Vd NA 1.517 L/kg 1compartment NA NA Rat Human +DTXSID8020834 Css NA 0.01633 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020834 Css NA 0.1204 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020834 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID8020834 Css NA 0.07753 mg/L PBTK NA 95% Rat Human +DTXSID8020838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020838 Fup 0.0317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020838 Vd NA 2.224 L/kg 1compartment NA NA Human Human +DTXSID8020838 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8020838 TK.Half.Life NA 18.17 hours 1compartment NA NA Human Human +DTXSID8020838 Css NA 1.139 mg/L 3compartmentss NA 50% Human Human +DTXSID8020838 Css NA 8.779 mg/L 3compartmentss NA 95% Human Human +DTXSID8020838 Css NA 0.747 mg/L PBTK NA 50% Human Human +DTXSID8020838 Css NA 5.409 mg/L PBTK NA 95% Human Human +DTXSID8020838 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020838 Fup 0.0317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020838 Vd NA 1.66 L/kg 1compartment NA NA Rat Human DTXSID8020838 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020838 TK.Half.Life NA 3.302 hours 1compartment NA NA Rat Human -DTXSID8020838 Css NA 0.3961 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020838 Css NA 2.214 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020838 Css NA 0.2424 mg/L PBTK NA 50% Rat Human -DTXSID8020838 Css NA 1.291 mg/L PBTK NA 95% Rat Human -DTXSID8020880 Clint NA 23.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020880 Fup NA 0.7135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020880 Vd NA 1.064 L/kg 1compartment NA NA Human Human +DTXSID8020838 TK.Half.Life NA 5.307 hours 1compartment NA NA Rat Human +DTXSID8020838 Css NA 0.1461 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020838 Css NA 0.9159 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020838 Css NA 0.09388 mg/L PBTK NA 50% Rat Human +DTXSID8020838 Css NA 0.5616 mg/L PBTK NA 95% Rat Human +DTXSID8020880 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020880 Fup 0.765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020880 Vd NA 1.05 L/kg 1compartment NA NA Human Human DTXSID8020880 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020880 TK.Half.Life NA 0.8408 hours 1compartment NA NA Human Human -DTXSID8020880 Css NA 0.02793 mg/L 3compartmentss NA 50% Human Human -DTXSID8020880 Css NA 0.28 mg/L 3compartmentss NA 95% Human Human -DTXSID8020880 Css NA 0.02374 mg/L PBTK NA 50% Human Human -DTXSID8020880 Css NA 0.1992 mg/L PBTK NA 95% Human Human -DTXSID8020880 Clint NA 23.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020880 Fup NA 0.7135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020880 Vd NA 1.009 L/kg 1compartment NA NA Rat Human +DTXSID8020880 TK.Half.Life NA 1.304 hours 1compartment NA NA Human Human +DTXSID8020880 Css NA 0.08795 mg/L 3compartmentss NA 50% Human Human +DTXSID8020880 Css NA 0.7241 mg/L 3compartmentss NA 95% Human Human +DTXSID8020880 Css NA 0.07572 mg/L PBTK NA 50% Human Human +DTXSID8020880 Css NA 0.5092 mg/L PBTK NA 95% Human Human +DTXSID8020880 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020880 Fup 0.765 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020880 Vd NA 1.004 L/kg 1compartment NA NA Rat Human DTXSID8020880 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020880 TK.Half.Life NA 0.3866 hours 1compartment NA NA Rat Human -DTXSID8020880 Css NA 0.01424 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020880 Css NA 0.1277 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020880 Css NA 0.01193 mg/L PBTK NA 50% Rat Human -DTXSID8020880 Css NA 0.08538 mg/L PBTK NA 95% Rat Human -DTXSID8020886 Clint NA 20.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020886 Fup NA 0.4657 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020886 Vd NA 1.137 L/kg 1compartment NA NA Human Human +DTXSID8020880 TK.Half.Life NA 0.6545 hours 1compartment NA NA Rat Human +DTXSID8020880 Css NA 0.009538 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020880 Css NA 0.07485 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020880 Css NA 0.008423 mg/L PBTK NA 50% Rat Human +DTXSID8020880 Css NA 0.0489 mg/L PBTK NA 95% Rat Human +DTXSID8020886 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020886 Fup 0.502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020886 Vd NA 1.186 L/kg 1compartment NA NA Human Human DTXSID8020886 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020886 TK.Half.Life NA 1.137 hours 1compartment NA NA Human Human -DTXSID8020886 Css NA 0.04372 mg/L 3compartmentss NA 50% Human Human -DTXSID8020886 Css NA 0.3729 mg/L 3compartmentss NA 95% Human Human -DTXSID8020886 Css NA 0.03685 mg/L PBTK NA 50% Human Human -DTXSID8020886 Css NA 0.2663 mg/L PBTK NA 95% Human Human -DTXSID8020886 Clint NA 20.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020886 Fup NA 0.4657 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020886 Vd NA 1.124 L/kg 1compartment NA NA Rat Human +DTXSID8020886 TK.Half.Life NA 1.952 hours 1compartment NA NA Human Human +DTXSID8020886 Css NA 0.1172 mg/L 3compartmentss NA 50% Human Human +DTXSID8020886 Css NA 0.9095 mg/L 3compartmentss NA 95% Human Human +DTXSID8020886 Css NA 0.0997 mg/L PBTK NA 50% Human Human +DTXSID8020886 Css NA 0.6474 mg/L PBTK NA 95% Human Human +DTXSID8020886 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020886 Fup 0.502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020886 Vd NA 1.174 L/kg 1compartment NA NA Rat Human DTXSID8020886 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020886 TK.Half.Life NA 0.5835 hours 1compartment NA NA Rat Human -DTXSID8020886 Css NA 0.02278 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020886 Css NA 0.1571 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020886 Css NA 0.01863 mg/L PBTK NA 50% Rat Human -DTXSID8020886 Css NA 0.1067 mg/L PBTK NA 95% Rat Human -DTXSID8020911 Clint NA 1.448 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020911 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020911 Vd NA 0.9803 L/kg 1compartment NA NA Human Human -DTXSID8020911 Days.Css NA 67 Days PBTK NA NA Human Human -DTXSID8020911 TK.Half.Life NA 284.9 hours 1compartment NA NA Human Human -DTXSID8020911 Css NA 50.24 mg/L 3compartmentss NA 50% Human Human -DTXSID8020911 Css NA 367.5 mg/L 3compartmentss NA 95% Human Human -DTXSID8020911 Css NA 30.76 mg/L PBTK NA 50% Human Human -DTXSID8020911 Css NA 215.8 mg/L PBTK NA 95% Human Human -DTXSID8020911 Clint NA 1.448 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020911 Fup NA 0.0053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020911 Vd NA 0.7306 L/kg 1compartment NA NA Rat Human -DTXSID8020911 Days.Css NA 27 Days PBTK NA NA Rat Human -DTXSID8020911 TK.Half.Life NA 110.8 hours 1compartment NA NA Rat Human -DTXSID8020911 Css NA 23.84 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020911 Css NA 140 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020911 Css NA 13.68 mg/L PBTK NA 50% Rat Human -DTXSID8020911 Css NA 76.48 mg/L PBTK NA 95% Rat Human -DTXSID8020915 Clint NA 1.061 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020915 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020915 Vd NA 0.2039 L/kg 1compartment NA NA Human Human -DTXSID8020915 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8020915 TK.Half.Life NA 18.15 hours 1compartment NA NA Human Human -DTXSID8020915 Css NA 15.62 mg/L 3compartmentss NA 50% Human Human -DTXSID8020915 Css NA 104.7 mg/L 3compartmentss NA 95% Human Human -DTXSID8020915 Css NA 9.182 mg/L PBTK NA 50% Human Human -DTXSID8020915 Css NA 60.6 mg/L PBTK NA 95% Human Human -DTXSID8020915 Clint NA 1.061 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020915 Fup NA 0.0264 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020915 Vd NA 0.1979 L/kg 1compartment NA NA Rat Human +DTXSID8020886 TK.Half.Life NA 1.074 hours 1compartment NA NA Rat Human +DTXSID8020886 Css NA 0.01346 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020886 Css NA 0.08633 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020886 Css NA 0.01156 mg/L PBTK NA 50% Rat Human +DTXSID8020886 Css NA 0.05775 mg/L PBTK NA 95% Rat Human +DTXSID8020911 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020911 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020911 Vd NA 1.967 L/kg 1compartment NA NA Human Human +DTXSID8020911 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8020911 TK.Half.Life NA 22.78 hours 1compartment NA NA Human Human +DTXSID8020911 Css NA 1.727 mg/L 3compartmentss NA 50% Human Human +DTXSID8020911 Css NA 17.09 mg/L 3compartmentss NA 95% Human Human +DTXSID8020911 Css NA 1.153 mg/L PBTK NA 50% Human Human +DTXSID8020911 Css NA 10.68 mg/L PBTK NA 95% Human Human +DTXSID8020911 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020911 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020911 Vd NA 1.48 L/kg 1compartment NA NA Rat Human +DTXSID8020911 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8020911 TK.Half.Life NA 9.267 hours 1compartment NA NA Rat Human +DTXSID8020911 Css NA 0.2275 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020911 Css NA 1.757 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020911 Css NA 0.1479 mg/L PBTK NA 50% Rat Human +DTXSID8020911 Css NA 1.063 mg/L PBTK NA 95% Rat Human +DTXSID8020915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020915 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020915 Vd NA 0.5112 L/kg 1compartment NA NA Human Human +DTXSID8020915 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8020915 TK.Half.Life NA 1.046 hours 1compartment NA NA Human Human +DTXSID8020915 Css NA 0.1808 mg/L 3compartmentss NA 50% Human Human +DTXSID8020915 Css NA 1.6 mg/L 3compartmentss NA 95% Human Human +DTXSID8020915 Css NA 0.1244 mg/L PBTK NA 50% Human Human +DTXSID8020915 Css NA 1.016 mg/L PBTK NA 95% Human Human +DTXSID8020915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020915 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020915 Vd NA 0.5012 L/kg 1compartment NA NA Rat Human DTXSID8020915 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020915 TK.Half.Life NA 8.919 hours 1compartment NA NA Rat Human -DTXSID8020915 Css NA 6.678 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020915 Css NA 37.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020915 Css NA 3.678 mg/L PBTK NA 50% Rat Human -DTXSID8020915 Css NA 20.19 mg/L PBTK NA 95% Rat Human -DTXSID8020917 Clint NA 35.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020917 Fup NA 0.3681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020917 Vd NA 2.672 L/kg 1compartment NA NA Human Human -DTXSID8020917 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020917 TK.Half.Life NA 2.089 hours 1compartment NA NA Human Human -DTXSID8020917 Css NA 0.02489 mg/L 3compartmentss NA 50% Human Human -DTXSID8020917 Css NA 0.2116 mg/L 3compartmentss NA 95% Human Human -DTXSID8020917 Css NA 0.02577 mg/L PBTK NA 50% Human Human -DTXSID8020917 Css NA 0.1813 mg/L PBTK NA 95% Human Human -DTXSID8020917 Clint NA 35.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020917 Fup NA 0.3681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020917 Vd NA 2.702 L/kg 1compartment NA NA Rat Human +DTXSID8020915 TK.Half.Life NA 0.5965 hours 1compartment NA NA Rat Human +DTXSID8020915 Css NA 0.02393 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020915 Css NA 0.1522 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020915 Css NA 0.01609 mg/L PBTK NA 50% Rat Human +DTXSID8020915 Css NA 0.09285 mg/L PBTK NA 95% Rat Human +DTXSID8020917 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020917 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020917 Vd NA 0.8729 L/kg 1compartment NA NA Human Human +DTXSID8020917 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8020917 TK.Half.Life NA 12.15 hours 1compartment NA NA Human Human +DTXSID8020917 Css NA 1.428 mg/L 3compartmentss NA 50% Human Human +DTXSID8020917 Css NA 6.934 mg/L 3compartmentss NA 95% Human Human +DTXSID8020917 Css NA 1.141 mg/L PBTK NA 50% Human Human +DTXSID8020917 Css NA 4.497 mg/L PBTK NA 95% Human Human +DTXSID8020917 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020917 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020917 Vd NA 0.8199 L/kg 1compartment NA NA Rat Human DTXSID8020917 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020917 TK.Half.Life NA 1.092 hours 1compartment NA NA Rat Human -DTXSID8020917 Css NA 0.01295 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020917 Css NA 0.09441 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020917 Css NA 0.01333 mg/L PBTK NA 50% Rat Human -DTXSID8020917 Css NA 0.07607 mg/L PBTK NA 95% Rat Human -DTXSID8020919 Clint NA 7.482 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020919 Fup NA 0.2122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020919 Vd NA 0.7745 L/kg 1compartment NA NA Human Human -DTXSID8020919 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020919 TK.Half.Life NA 2.33 hours 1compartment NA NA Human Human -DTXSID8020919 Css NA 0.2909 mg/L 3compartmentss NA 50% Human Human -DTXSID8020919 Css NA 1.766 mg/L 3compartmentss NA 95% Human Human -DTXSID8020919 Css NA 0.2011 mg/L PBTK NA 50% Human Human -DTXSID8020919 Css NA 1.14 mg/L PBTK NA 95% Human Human -DTXSID8020919 Clint NA 7.482 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020919 Fup NA 0.2122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020919 Vd NA 0.6641 L/kg 1compartment NA NA Rat Human -DTXSID8020919 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020919 TK.Half.Life NA 1.137 hours 1compartment NA NA Rat Human -DTXSID8020919 Css NA 0.1516 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020919 Css NA 0.6678 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020919 Css NA 0.09946 mg/L PBTK NA 50% Rat Human -DTXSID8020919 Css NA 0.4005 mg/L PBTK NA 95% Rat Human -DTXSID8020963 Clint NA 1.244 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020963 Fup NA 0.1165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020963 Vd NA 0.3765 L/kg 1compartment NA NA Human Human +DTXSID8020917 TK.Half.Life NA 3.802 hours 1compartment NA NA Rat Human +DTXSID8020917 Css NA 0.08876 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020917 Css NA 0.394 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020917 Css NA 0.07055 mg/L PBTK NA 50% Rat Human +DTXSID8020917 Css NA 0.2472 mg/L PBTK NA 95% Rat Human +DTXSID8020919 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020919 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020919 Vd NA 1.48 L/kg 1compartment NA NA Human Human +DTXSID8020919 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8020919 TK.Half.Life NA 43.73 hours 1compartment NA NA Human Human +DTXSID8020919 Css NA 3.114 mg/L 3compartmentss NA 50% Human Human +DTXSID8020919 Css NA 11.49 mg/L 3compartmentss NA 95% Human Human +DTXSID8020919 Css NA 2.354 mg/L PBTK NA 50% Human Human +DTXSID8020919 Css NA 7.561 mg/L PBTK NA 95% Human Human +DTXSID8020919 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020919 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020919 Vd NA 1.194 L/kg 1compartment NA NA Rat Human +DTXSID8020919 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8020919 TK.Half.Life NA 10 hours 1compartment NA NA Rat Human +DTXSID8020919 Css NA 0.1992 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020919 Css NA 0.6238 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020919 Css NA 0.149 mg/L PBTK NA 50% Rat Human +DTXSID8020919 Css NA 0.3933 mg/L PBTK NA 95% Rat Human +DTXSID8020963 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020963 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020963 Vd NA 0.4993 L/kg 1compartment NA NA Human Human DTXSID8020963 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8020963 TK.Half.Life NA 6.972 hours 1compartment NA NA Human Human -DTXSID8020963 Css NA 2.79 mg/L 3compartmentss NA 50% Human Human -DTXSID8020963 Css NA 15.17 mg/L 3compartmentss NA 95% Human Human -DTXSID8020963 Css NA 1.786 mg/L PBTK NA 50% Human Human -DTXSID8020963 Css NA 9.026 mg/L PBTK NA 95% Human Human -DTXSID8020963 Clint NA 1.244 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020963 Fup NA 0.1165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020963 Vd NA 0.3733 L/kg 1compartment NA NA Rat Human +DTXSID8020963 TK.Half.Life NA 0.8019 hours 1compartment NA NA Human Human +DTXSID8020963 Css NA 0.1015 mg/L 3compartmentss NA 50% Human Human +DTXSID8020963 Css NA 0.7299 mg/L 3compartmentss NA 95% Human Human +DTXSID8020963 Css NA 0.07118 mg/L PBTK NA 50% Human Human +DTXSID8020963 Css NA 0.4835 mg/L PBTK NA 95% Human Human +DTXSID8020963 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020963 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020963 Vd NA 0.4975 L/kg 1compartment NA NA Rat Human DTXSID8020963 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020963 TK.Half.Life NA 3.564 hours 1compartment NA NA Rat Human -DTXSID8020963 Css NA 1.193 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020963 Css NA 5.094 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020963 Css NA 0.719 mg/L PBTK NA 50% Rat Human -DTXSID8020963 Css NA 2.842 mg/L PBTK NA 95% Rat Human -DTXSID8020965 Clint NA 0.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020965 Fup NA 0.3858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8020965 Vd NA 1.065 L/kg 1compartment NA NA Human Human -DTXSID8020965 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8020965 TK.Half.Life NA 14.89 hours 1compartment NA NA Human Human -DTXSID8020965 Css NA 1.439 mg/L 3compartmentss NA 50% Human Human -DTXSID8020965 Css NA 6.408 mg/L 3compartmentss NA 95% Human Human -DTXSID8020965 Css NA 1.124 mg/L PBTK NA 50% Human Human -DTXSID8020965 Css NA 4.175 mg/L PBTK NA 95% Human Human -DTXSID8020965 Clint NA 0.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020965 Fup NA 0.3858 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8020965 Vd NA 0.9301 L/kg 1compartment NA NA Rat Human +DTXSID8020963 TK.Half.Life NA 0.4446 hours 1compartment NA NA Rat Human +DTXSID8020963 Css NA 0.01288 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020963 Css NA 0.06999 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020963 Css NA 0.00889 mg/L PBTK NA 50% Rat Human +DTXSID8020963 Css NA 0.04495 mg/L PBTK NA 95% Rat Human +DTXSID8020965 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020965 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8020965 Vd NA 0.6681 L/kg 1compartment NA NA Human Human +DTXSID8020965 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8020965 TK.Half.Life NA 1.234 hours 1compartment NA NA Human Human +DTXSID8020965 Css NA 0.132 mg/L 3compartmentss NA 50% Human Human +DTXSID8020965 Css NA 0.9652 mg/L 3compartmentss NA 95% Human Human +DTXSID8020965 Css NA 0.08836 mg/L PBTK NA 50% Human Human +DTXSID8020965 Css NA 0.6124 mg/L PBTK NA 95% Human Human +DTXSID8020965 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020965 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8020965 Vd NA 0.5797 L/kg 1compartment NA NA Rat Human DTXSID8020965 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8020965 TK.Half.Life NA 4.722 hours 1compartment NA NA Rat Human -DTXSID8020965 Css NA 0.4592 mg/L 3compartmentss NA 50% Rat Human -DTXSID8020965 Css NA 1.686 mg/L 3compartmentss NA 95% Rat Human -DTXSID8020965 Css NA 0.3438 mg/L PBTK NA 50% Rat Human -DTXSID8020965 Css NA 1.031 mg/L PBTK NA 95% Rat Human -DTXSID8021060 Clint NA 0.6335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021060 Fup NA 0.9879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021060 Vd NA 1.071 L/kg 1compartment NA NA Human Human +DTXSID8020965 TK.Half.Life NA 0.596 hours 1compartment NA NA Rat Human +DTXSID8020965 Css NA 0.01711 mg/L 3compartmentss NA 50% Rat Human +DTXSID8020965 Css NA 0.09079 mg/L 3compartmentss NA 95% Rat Human +DTXSID8020965 Css NA 0.01129 mg/L PBTK NA 50% Rat Human +DTXSID8020965 Css NA 0.05771 mg/L PBTK NA 95% Rat Human +DTXSID80209993 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80209993 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80209993 Vd NA 0.5281 L/kg 1compartment NA NA Human Human +DTXSID80209993 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID80209993 TK.Half.Life NA 13.09 hours 1compartment NA NA Human Human +DTXSID80209993 Css NA 2.712 mg/L 3compartmentss NA 50% Human Human +DTXSID80209993 Css NA 10.46 mg/L 3compartmentss NA 95% Human Human +DTXSID80209993 Css NA 1.954 mg/L PBTK NA 50% Human Human +DTXSID80209993 Css NA 6.751 mg/L PBTK NA 95% Human Human +DTXSID80209993 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80209993 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80209993 Vd NA 0.5306 L/kg 1compartment NA NA Rat Human +DTXSID80209993 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80209993 TK.Half.Life NA 4.483 hours 1compartment NA NA Rat Human +DTXSID80209993 Css NA 0.1766 mg/L 3compartmentss NA 50% Rat Human +DTXSID80209993 Css NA 0.5787 mg/L 3compartmentss NA 95% Rat Human +DTXSID80209993 Css NA 0.1248 mg/L PBTK NA 50% Rat Human +DTXSID80209993 Css NA 0.3537 mg/L PBTK NA 95% Rat Human +DTXSID8021060 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021060 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021060 Vd NA 0.9172 L/kg 1compartment NA NA Human Human DTXSID8021060 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021060 TK.Half.Life NA 3.625 hours 1compartment NA NA Human Human -DTXSID8021060 Css NA 0.3735 mg/L 3compartmentss NA 50% Human Human -DTXSID8021060 Css NA 2.867 mg/L 3compartmentss NA 95% Human Human -DTXSID8021060 Css NA 0.3372 mg/L PBTK NA 50% Human Human -DTXSID8021060 Css NA 1.909 mg/L PBTK NA 95% Human Human -DTXSID8021060 Clint NA 0.6335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021060 Fup NA 0.9879 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021060 Vd NA 1.064 L/kg 1compartment NA NA Rat Human +DTXSID8021060 TK.Half.Life NA 7.815 hours 1compartment NA NA Human Human +DTXSID8021060 Css NA 0.9644 mg/L 3compartmentss NA 50% Human Human +DTXSID8021060 Css NA 6.305 mg/L 3compartmentss NA 95% Human Human +DTXSID8021060 Css NA 0.8212 mg/L PBTK NA 50% Human Human +DTXSID8021060 Css NA 4.109 mg/L PBTK NA 95% Human Human +DTXSID8021060 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021060 Fup 0.769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021060 Vd NA 0.9103 L/kg 1compartment NA NA Rat Human DTXSID8021060 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021060 TK.Half.Life NA 1.607 hours 1compartment NA NA Rat Human -DTXSID8021060 Css NA 0.1292 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021060 Css NA 0.9693 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021060 Css NA 0.1155 mg/L PBTK NA 50% Rat Human -DTXSID8021060 Css NA 0.5894 mg/L PBTK NA 95% Rat Human +DTXSID8021060 TK.Half.Life NA 2.619 hours 1compartment NA NA Rat Human +DTXSID8021060 Css NA 0.05655 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021060 Css NA 0.3561 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021060 Css NA 0.04863 mg/L PBTK NA 50% Rat Human +DTXSID8021060 Css NA 0.2224 mg/L PBTK NA 95% Rat Human DTXSID8021062 Clint NA 0.4719 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021062 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021062 Vd NA 0.9248 L/kg 1compartment NA NA Human Human DTXSID8021062 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8021062 TK.Half.Life NA 3.474 hours 1compartment NA NA Human Human -DTXSID8021062 Css NA 0.4465 mg/L 3compartmentss NA 50% Human Human -DTXSID8021062 Css NA 2.967 mg/L 3compartmentss NA 95% Human Human -DTXSID8021062 Css NA 0.3882 mg/L PBTK NA 50% Human Human -DTXSID8021062 Css NA 1.945 mg/L PBTK NA 95% Human Human +DTXSID8021062 Css NA 0.3704 mg/L 3compartmentss NA 50% Human Human +DTXSID8021062 Css NA 2.46 mg/L 3compartmentss NA 95% Human Human +DTXSID8021062 Css NA 0.323 mg/L PBTK NA 50% Human Human +DTXSID8021062 Css NA 1.67 mg/L PBTK NA 95% Human Human DTXSID8021062 Clint NA 0.4719 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021062 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021062 Vd NA 0.9443 L/kg 1compartment NA NA Rat Human DTXSID8021062 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8021062 TK.Half.Life NA 1.529 hours 1compartment NA NA Rat Human -DTXSID8021062 Css NA 0.1456 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021062 Css NA 0.9779 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021062 Css NA 0.1258 mg/L PBTK NA 50% Rat Human -DTXSID8021062 Css NA 0.5932 mg/L PBTK NA 95% Rat Human -DTXSID8021141 Clint NA 4.331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021141 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021141 Vd NA 0.9029 L/kg 1compartment NA NA Human Human +DTXSID8021062 Css NA 0.0086 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021062 Css NA 0.07834 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021062 Css NA 0.007322 mg/L PBTK NA 50% Rat Human +DTXSID8021062 Css NA 0.05036 mg/L PBTK NA 95% Rat Human +DTXSID8021141 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021141 Fup 0.624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021141 Vd NA 0.7315 L/kg 1compartment NA NA Human Human DTXSID8021141 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021141 TK.Half.Life NA 1.096 hours 1compartment NA NA Human Human -DTXSID8021141 Css NA 0.1034 mg/L 3compartmentss NA 50% Human Human -DTXSID8021141 Css NA 0.9068 mg/L 3compartmentss NA 95% Human Human -DTXSID8021141 Css NA 0.08844 mg/L PBTK NA 50% Human Human -DTXSID8021141 Css NA 0.6512 mg/L PBTK NA 95% Human Human -DTXSID8021141 Clint NA 4.331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021141 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021141 Vd NA 0.9256 L/kg 1compartment NA NA Rat Human +DTXSID8021141 TK.Half.Life NA 7.621 hours 1compartment NA NA Human Human +DTXSID8021141 Css NA 1.014 mg/L 3compartmentss NA 50% Human Human +DTXSID8021141 Css NA 6.855 mg/L 3compartmentss NA 95% Human Human +DTXSID8021141 Css NA 0.8152 mg/L PBTK NA 50% Human Human +DTXSID8021141 Css NA 4.303 mg/L PBTK NA 95% Human Human +DTXSID8021141 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021141 Fup 0.624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021141 Vd NA 0.7382 L/kg 1compartment NA NA Rat Human DTXSID8021141 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021141 TK.Half.Life NA 0.5879 hours 1compartment NA NA Rat Human -DTXSID8021141 Css NA 0.04708 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021141 Css NA 0.3278 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021141 Css NA 0.0401 mg/L PBTK NA 50% Rat Human -DTXSID8021141 Css NA 0.2143 mg/L PBTK NA 95% Rat Human -DTXSID8021145 Clint NA 17.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021145 Fup NA 0.4717 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021145 Vd NA 1.602 L/kg 1compartment NA NA Human Human +DTXSID8021141 TK.Half.Life NA 2.611 hours 1compartment NA NA Rat Human +DTXSID8021141 Css NA 0.01911 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021141 Css NA 0.1618 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021141 Css NA 0.01492 mg/L PBTK NA 50% Rat Human +DTXSID8021141 Css NA 0.1021 mg/L PBTK NA 95% Rat Human +DTXSID8021145 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021145 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021145 Vd NA 1.683 L/kg 1compartment NA NA Human Human DTXSID8021145 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021145 TK.Half.Life NA 1.869 hours 1compartment NA NA Human Human -DTXSID8021145 Css NA 0.06108 mg/L 3compartmentss NA 50% Human Human -DTXSID8021145 Css NA 0.4854 mg/L 3compartmentss NA 95% Human Human -DTXSID8021145 Css NA 0.05049 mg/L PBTK NA 50% Human Human -DTXSID8021145 Css NA 0.3529 mg/L PBTK NA 95% Human Human -DTXSID8021145 Clint NA 17.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021145 Fup NA 0.4717 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8021145 TK.Half.Life NA 2.647 hours 1compartment NA NA Human Human +DTXSID8021145 Css NA 0.09904 mg/L 3compartmentss NA 50% Human Human +DTXSID8021145 Css NA 0.6821 mg/L 3compartmentss NA 95% Human Human +DTXSID8021145 Css NA 0.07372 mg/L PBTK NA 50% Human Human +DTXSID8021145 Css NA 0.4732 mg/L PBTK NA 95% Human Human +DTXSID8021145 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021145 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8021145 Vd NA 1.332 L/kg 1compartment NA NA Rat Human DTXSID8021145 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021145 TK.Half.Life NA 0.7476 hours 1compartment NA NA Rat Human -DTXSID8021145 Css NA 0.0325 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021145 Css NA 0.1964 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021145 Css NA 0.02586 mg/L PBTK NA 50% Rat Human -DTXSID8021145 Css NA 0.1347 mg/L PBTK NA 95% Rat Human -DTXSID8021147 Clint NA 16.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021147 Fup NA 0.672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021147 Vd NA 1.245 L/kg 1compartment NA NA Human Human +DTXSID8021145 TK.Half.Life NA 0.9991 hours 1compartment NA NA Rat Human +DTXSID8021145 Css NA 0.0125 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021145 Css NA 0.06616 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021145 Css NA 0.009275 mg/L PBTK NA 50% Rat Human +DTXSID8021145 Css NA 0.04505 mg/L PBTK NA 95% Rat Human +DTXSID8021147 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021147 Fup 0.563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021147 Vd NA 1.122 L/kg 1compartment NA NA Human Human DTXSID8021147 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021147 TK.Half.Life NA 1.128 hours 1compartment NA NA Human Human -DTXSID8021147 Css NA 0.04134 mg/L 3compartmentss NA 50% Human Human -DTXSID8021147 Css NA 0.4211 mg/L 3compartmentss NA 95% Human Human -DTXSID8021147 Css NA 0.03558 mg/L PBTK NA 50% Human Human -DTXSID8021147 Css NA 0.2984 mg/L PBTK NA 95% Human Human -DTXSID8021147 Clint NA 16.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021147 Fup NA 0.672 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021147 Vd NA 1.128 L/kg 1compartment NA NA Rat Human +DTXSID8021147 TK.Half.Life NA 1.031 hours 1compartment NA NA Human Human +DTXSID8021147 Css NA 0.03486 mg/L 3compartmentss NA 50% Human Human +DTXSID8021147 Css NA 0.3653 mg/L 3compartmentss NA 95% Human Human +DTXSID8021147 Css NA 0.0289 mg/L PBTK NA 50% Human Human +DTXSID8021147 Css NA 0.2554 mg/L PBTK NA 95% Human Human +DTXSID8021147 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021147 Fup 0.563 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021147 Vd NA 1.016 L/kg 1compartment NA NA Rat Human DTXSID8021147 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021147 TK.Half.Life NA 0.5056 hours 1compartment NA NA Rat Human -DTXSID8021147 Css NA 0.02043 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021147 Css NA 0.1821 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021147 Css NA 0.0174 mg/L PBTK NA 50% Rat Human -DTXSID8021147 Css NA 0.1184 mg/L PBTK NA 95% Rat Human -DTXSID8021191 Clint NA 9.739 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021191 Fup NA 0.3617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021191 Vd NA 2.702 L/kg 1compartment NA NA Human Human +DTXSID8021147 TK.Half.Life NA 0.4606 hours 1compartment NA NA Rat Human +DTXSID8021147 Css NA 0.004227 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021147 Css NA 0.04012 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021147 Css NA 0.003548 mg/L PBTK NA 50% Rat Human +DTXSID8021147 Css NA 0.02588 mg/L PBTK NA 95% Rat Human +DTXSID8021191 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021191 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021191 Vd NA 1.925 L/kg 1compartment NA NA Human Human DTXSID8021191 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021191 TK.Half.Life NA 3.936 hours 1compartment NA NA Human Human -DTXSID8021191 Css NA 0.0853 mg/L 3compartmentss NA 50% Human Human -DTXSID8021191 Css NA 0.6736 mg/L 3compartmentss NA 95% Human Human -DTXSID8021191 Css NA 0.0887 mg/L PBTK NA 50% Human Human -DTXSID8021191 Css NA 0.5591 mg/L PBTK NA 95% Human Human -DTXSID8021191 Clint NA 9.739 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021191 Fup NA 0.3617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021191 Vd NA 2.734 L/kg 1compartment NA NA Rat Human +DTXSID8021191 TK.Half.Life NA 3.713 hours 1compartment NA NA Human Human +DTXSID8021191 Css NA 0.1621 mg/L 3compartmentss NA 50% Human Human +DTXSID8021191 Css NA 1.503 mg/L 3compartmentss NA 95% Human Human +DTXSID8021191 Css NA 0.1282 mg/L PBTK NA 50% Human Human +DTXSID8021191 Css NA 1.018 mg/L PBTK NA 95% Human Human +DTXSID8021191 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021191 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021191 Vd NA 1.902 L/kg 1compartment NA NA Rat Human DTXSID8021191 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021191 TK.Half.Life NA 2.283 hours 1compartment NA NA Rat Human -DTXSID8021191 Css NA 0.04243 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021191 Css NA 0.2751 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021191 Css NA 0.04424 mg/L PBTK NA 50% Rat Human -DTXSID8021191 Css NA 0.2124 mg/L PBTK NA 95% Rat Human -DTXSID8021193 Clint NA 51.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021193 Fup NA 0.2273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021193 Vd NA 2.703 L/kg 1compartment NA NA Human Human +DTXSID8021191 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human +DTXSID8021191 Css NA 0.02091 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021191 Css NA 0.1448 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021191 Css NA 0.01646 mg/L PBTK NA 50% Rat Human +DTXSID8021191 Css NA 0.09754 mg/L PBTK NA 95% Rat Human +DTXSID8021193 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021193 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021193 Vd NA 2.751 L/kg 1compartment NA NA Human Human DTXSID8021193 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021193 TK.Half.Life NA 2.036 hours 1compartment NA NA Human Human -DTXSID8021193 Css NA 0.02154 mg/L 3compartmentss NA 50% Human Human -DTXSID8021193 Css NA 0.1891 mg/L 3compartmentss NA 95% Human Human -DTXSID8021193 Css NA 0.02304 mg/L PBTK NA 50% Human Human -DTXSID8021193 Css NA 0.1647 mg/L PBTK NA 95% Human Human -DTXSID8021193 Clint NA 51.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021193 Fup NA 0.2273 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021193 Vd NA 2.697 L/kg 1compartment NA NA Rat Human +DTXSID8021193 TK.Half.Life NA 2.951 hours 1compartment NA NA Human Human +DTXSID8021193 Css NA 0.04661 mg/L 3compartmentss NA 50% Human Human +DTXSID8021193 Css NA 0.388 mg/L 3compartmentss NA 95% Human Human +DTXSID8021193 Css NA 0.05032 mg/L PBTK NA 50% Human Human +DTXSID8021193 Css NA 0.3445 mg/L PBTK NA 95% Human Human +DTXSID8021193 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021193 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021193 Vd NA 2.746 L/kg 1compartment NA NA Rat Human DTXSID8021193 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021193 TK.Half.Life NA 1.055 hours 1compartment NA NA Rat Human -DTXSID8021193 Css NA 0.01146 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021193 Css NA 0.08309 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021193 Css NA 0.01221 mg/L PBTK NA 50% Rat Human -DTXSID8021193 Css NA 0.06945 mg/L PBTK NA 95% Rat Human +DTXSID8021193 TK.Half.Life NA 1.667 hours 1compartment NA NA Rat Human +DTXSID8021193 Css NA 0.005656 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021193 Css NA 0.03756 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021193 Css NA 0.00634 mg/L PBTK NA 50% Rat Human +DTXSID8021193 Css NA 0.03367 mg/L PBTK NA 95% Rat Human +DTXSID8021195 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8021195 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8021195 Vd NA 0.8871 L/kg 1compartment NA NA Human Human +DTXSID8021195 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8021195 TK.Half.Life NA 5.762 hours 1compartment NA NA Human Human +DTXSID8021195 Css NA 0.6832 mg/L 3compartmentss NA 50% Human Human +DTXSID8021195 Css NA 4.888 mg/L 3compartmentss NA 95% Human Human +DTXSID8021195 Css NA 0.5941 mg/L PBTK NA 50% Human Human +DTXSID8021195 Css NA 3.266 mg/L PBTK NA 95% Human Human +DTXSID8021195 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8021195 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8021195 Vd NA 0.9093 L/kg 1compartment NA NA Rat Human +DTXSID8021195 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8021195 TK.Half.Life NA 2.007 hours 1compartment NA NA Rat Human +DTXSID8021195 Css NA 0.0125 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021195 Css NA 0.1036 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021195 Css NA 0.01061 mg/L PBTK NA 50% Rat Human +DTXSID8021195 Css NA 0.06811 mg/L PBTK NA 95% Rat Human DTXSID8021197 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021197 Fup NA 0.6755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021197 Vd NA 0.6478 L/kg 1compartment NA NA Human Human +DTXSID8021197 Vd NA 0.646 L/kg 1compartment NA NA Human Human DTXSID8021197 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021197 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human -DTXSID8021197 Css NA 1.131 mg/L 3compartmentss NA 50% Human Human -DTXSID8021197 Css NA 7.376 mg/L 3compartmentss NA 95% Human Human -DTXSID8021197 Css NA 0.905 mg/L PBTK NA 50% Human Human -DTXSID8021197 Css NA 4.67 mg/L PBTK NA 95% Human Human +DTXSID8021197 TK.Half.Life NA 6.194 hours 1compartment NA NA Human Human +DTXSID8021197 Css NA 0.9642 mg/L 3compartmentss NA 50% Human Human +DTXSID8021197 Css NA 6.456 mg/L 3compartmentss NA 95% Human Human +DTXSID8021197 Css NA 0.767 mg/L PBTK NA 50% Human Human +DTXSID8021197 Css NA 4.083 mg/L PBTK NA 95% Human Human DTXSID8021197 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021197 Fup NA 0.6755 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021197 Vd NA 0.6719 L/kg 1compartment NA NA Rat Human +DTXSID8021197 Vd NA 0.6708 L/kg 1compartment NA NA Rat Human DTXSID8021197 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021197 TK.Half.Life NA 2.194 hours 1compartment NA NA Rat Human -DTXSID8021197 Css NA 0.2954 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021197 Css NA 1.885 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021197 Css NA 0.2264 mg/L PBTK NA 50% Rat Human -DTXSID8021197 Css NA 1.105 mg/L PBTK NA 95% Rat Human +DTXSID8021197 TK.Half.Life NA 2.19 hours 1compartment NA NA Rat Human +DTXSID8021197 Css NA 0.01828 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021197 Css NA 0.1572 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021197 Css NA 0.01399 mg/L PBTK NA 50% Rat Human +DTXSID8021197 Css NA 0.09917 mg/L PBTK NA 95% Rat Human DTXSID8021199 Clint 159 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8021199 Fup 5.36e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8021199 Vd NA 0.229 L/kg 1compartment NA NA Human Human DTXSID8021199 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID8021199 TK.Half.Life NA 30.2 hours 1compartment NA NA Human Human -DTXSID8021199 Css NA 0.3463 mg/L 3compartmentss NA 50% Human Human -DTXSID8021199 Css NA 4.022 mg/L 3compartmentss NA 95% Human Human -DTXSID8021199 Css NA 0.2158 mg/L PBTK NA 50% Human Human -DTXSID8021199 Css NA 2.431 mg/L PBTK NA 95% Human Human +DTXSID8021199 Css NA 0.3314 mg/L 3compartmentss NA 50% Human Human +DTXSID8021199 Css NA 3.86 mg/L 3compartmentss NA 95% Human Human +DTXSID8021199 Css NA 0.2062 mg/L PBTK NA 50% Human Human +DTXSID8021199 Css NA 2.345 mg/L PBTK NA 95% Human Human DTXSID8021199 Clint 159 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8021199 Fup 5.36e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8021199 Vd NA 0.1949 L/kg 1compartment NA NA Rat Human DTXSID8021199 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID8021199 TK.Half.Life NA 17.96 hours 1compartment NA NA Rat Human -DTXSID8021199 Css NA 0.19 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021199 Css NA 2.036 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021199 Css NA 0.1117 mg/L PBTK NA 50% Rat Human -DTXSID8021199 Css NA 1.149 mg/L PBTK NA 95% Rat Human +DTXSID8021199 Css NA 0.04194 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021199 Css NA 0.449 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021199 Css NA 0.02551 mg/L PBTK NA 50% Rat Human +DTXSID8021199 Css NA 0.2632 mg/L PBTK NA 95% Rat Human DTXSID8021222 Clint NA 1.015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021222 Fup NA 0.8519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021222 Vd NA 0.901 L/kg 1compartment NA NA Human Human DTXSID8021222 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8021222 TK.Half.Life NA 2.735 hours 1compartment NA NA Human Human -DTXSID8021222 Css NA 0.3304 mg/L 3compartmentss NA 50% Human Human -DTXSID8021222 Css NA 2.31 mg/L 3compartmentss NA 95% Human Human -DTXSID8021222 Css NA 0.2981 mg/L PBTK NA 50% Human Human -DTXSID8021222 Css NA 1.569 mg/L PBTK NA 95% Human Human +DTXSID8021222 Css NA 0.3185 mg/L 3compartmentss NA 50% Human Human +DTXSID8021222 Css NA 2.205 mg/L 3compartmentss NA 95% Human Human +DTXSID8021222 Css NA 0.2874 mg/L PBTK NA 50% Human Human +DTXSID8021222 Css NA 1.469 mg/L PBTK NA 95% Human Human DTXSID8021222 Clint NA 1.015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021222 Fup NA 0.8519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021222 Vd NA 0.9097 L/kg 1compartment NA NA Rat Human DTXSID8021222 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8021222 TK.Half.Life NA 1.338 hours 1compartment NA NA Rat Human -DTXSID8021222 Css NA 0.1238 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021222 Css NA 0.7853 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021222 Css NA 0.1104 mg/L PBTK NA 50% Rat Human -DTXSID8021222 Css NA 0.4926 mg/L PBTK NA 95% Rat Human +DTXSID8021222 Css NA 0.02762 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021222 Css NA 0.1705 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021222 Css NA 0.02551 mg/L PBTK NA 50% Rat Human +DTXSID8021222 Css NA 0.1107 mg/L PBTK NA 95% Rat Human DTXSID8021224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021224 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021224 Vd NA 0.3769 L/kg 1compartment NA NA Human Human -DTXSID8021224 Days.Css NA 149 Days PBTK NA NA Human Human -DTXSID8021224 TK.Half.Life NA 579.6 hours 1compartment NA NA Human Human -DTXSID8021224 Css NA 266.3 mg/L 3compartmentss NA 50% Human Human -DTXSID8021224 Css NA 1510 mg/L 3compartmentss NA 95% Human Human -DTXSID8021224 Css NA 156.3 mg/L PBTK NA 50% Human Human -DTXSID8021224 Css NA 879.5 mg/L PBTK NA 95% Human Human +DTXSID8021224 Vd NA 0.1624 L/kg 1compartment NA NA Human Human +DTXSID8021224 Days.Css NA 59 Days PBTK NA NA Human Human +DTXSID8021224 TK.Half.Life NA 244.3 hours 1compartment NA NA Human Human +DTXSID8021224 Css NA 141.4 mg/L 3compartmentss NA 50% Human Human +DTXSID8021224 Css NA 878.8 mg/L 3compartmentss NA 95% Human Human +DTXSID8021224 Css NA 81.72 mg/L PBTK NA 50% Human Human +DTXSID8021224 Css NA 497.7 mg/L PBTK NA 95% Human Human DTXSID8021224 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021224 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021224 Vd NA 0.2931 L/kg 1compartment NA NA Rat Human -DTXSID8021224 Days.Css NA 35 Days PBTK NA NA Rat Human -DTXSID8021224 TK.Half.Life NA 151 hours 1compartment NA NA Rat Human -DTXSID8021224 Css NA 76.08 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021224 Css NA 370.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021224 Css NA 41.47 mg/L PBTK NA 50% Rat Human -DTXSID8021224 Css NA 200.3 mg/L PBTK NA 95% Rat Human -DTXSID8021270 Clint NA 20.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021270 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021270 Vd NA 1.82 L/kg 1compartment NA NA Human Human -DTXSID8021270 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID8021270 TK.Half.Life NA 67.49 hours 1compartment NA NA Human Human -DTXSID8021270 Css NA 6.205 mg/L 3compartmentss NA 50% Human Human -DTXSID8021270 Css NA 46.75 mg/L 3compartmentss NA 95% Human Human -DTXSID8021270 Css NA 3.878 mg/L PBTK NA 50% Human Human -DTXSID8021270 Css NA 28.55 mg/L PBTK NA 95% Human Human -DTXSID8021270 Clint NA 20.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021270 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021270 Vd NA 1.341 L/kg 1compartment NA NA Rat Human -DTXSID8021270 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID8021270 TK.Half.Life NA 24.01 hours 1compartment NA NA Rat Human -DTXSID8021270 Css NA 3.532 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021270 Css NA 20.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021270 Css NA 2.082 mg/L PBTK NA 50% Rat Human -DTXSID8021270 Css NA 11.94 mg/L PBTK NA 95% Rat Human +DTXSID8021224 Vd NA 0.1611 L/kg 1compartment NA NA Rat Human +DTXSID8021224 Days.Css NA 17 Days PBTK NA NA Rat Human +DTXSID8021224 TK.Half.Life NA 82.6 hours 1compartment NA NA Rat Human +DTXSID8021224 Css NA 0.773 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021224 Css NA 4.705 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021224 Css NA 0.4192 mg/L PBTK NA 50% Rat Human +DTXSID8021224 Css NA 2.548 mg/L PBTK NA 95% Rat Human +DTXSID8021270 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021270 Fup 0.00515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021270 Vd NA 2.373 L/kg 1compartment NA NA Human Human +DTXSID8021270 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID8021270 TK.Half.Life NA 53.82 hours 1compartment NA NA Human Human +DTXSID8021270 Css NA 3.36 mg/L 3compartmentss NA 50% Human Human +DTXSID8021270 Css NA 26.87 mg/L 3compartmentss NA 95% Human Human +DTXSID8021270 Css NA 2.201 mg/L PBTK NA 50% Human Human +DTXSID8021270 Css NA 16.8 mg/L PBTK NA 95% Human Human +DTXSID8021270 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021270 Fup 0.00515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021270 Vd NA 1.764 L/kg 1compartment NA NA Rat Human +DTXSID8021270 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID8021270 TK.Half.Life NA 14.78 hours 1compartment NA NA Rat Human +DTXSID8021270 Css NA 0.4454 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021270 Css NA 2.889 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021270 Css NA 0.285 mg/L PBTK NA 50% Rat Human +DTXSID8021270 Css NA 1.77 mg/L PBTK NA 95% Rat Human DTXSID8021272 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8021272 Fup NA 0.3056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021272 Vd NA 0.4265 L/kg 1compartment NA NA Human Human -DTXSID8021272 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021272 TK.Half.Life NA 9.03 hours 1compartment NA NA Human Human -DTXSID8021272 Css NA 0.006068 mg/L 3compartmentss NA 50% Human Human -DTXSID8021272 Css NA 0.06288 mg/L 3compartmentss NA 95% Human Human -DTXSID8021272 Css NA 0.004212 mg/L PBTK NA 50% Human Human -DTXSID8021272 Css NA 0.04051 mg/L PBTK NA 95% Human Human +DTXSID8021272 Vd NA 0.4514 L/kg 1compartment NA NA Human Human +DTXSID8021272 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8021272 TK.Half.Life NA 9.569 hours 1compartment NA NA Human Human +DTXSID8021272 Css NA 0.002982 mg/L 3compartmentss NA 50% Human Human +DTXSID8021272 Css NA 0.05631 mg/L 3compartmentss NA 95% Human Human +DTXSID8021272 Css NA 0.002094 mg/L PBTK NA 50% Human Human +DTXSID8021272 Css NA 0.03769 mg/L PBTK NA 95% Human Human DTXSID8021272 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8021272 Fup NA 0.3056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021272 Vd NA 0.4405 L/kg 1compartment NA NA Rat Human +DTXSID8021272 Vd NA 0.4587 L/kg 1compartment NA NA Rat Human DTXSID8021272 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021272 TK.Half.Life NA 3.178 hours 1compartment NA NA Rat Human -DTXSID8021272 Css NA 0.003473 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021272 Css NA 0.02632 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021272 Css NA 0.002337 mg/L PBTK NA 50% Rat Human -DTXSID8021272 Css NA 0.01649 mg/L PBTK NA 95% Rat Human -DTXSID8021276 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021276 Fup NA 0.4532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021276 Vd NA 0.5404 L/kg 1compartment NA NA Human Human -DTXSID8021276 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021276 TK.Half.Life NA 7.734 hours 1compartment NA NA Human Human -DTXSID8021276 Css NA 1.607 mg/L 3compartmentss NA 50% Human Human -DTXSID8021276 Css NA 7.573 mg/L 3compartmentss NA 95% Human Human -DTXSID8021276 Css NA 1.188 mg/L PBTK NA 50% Human Human -DTXSID8021276 Css NA 4.746 mg/L PBTK NA 95% Human Human -DTXSID8021276 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021276 Fup NA 0.4532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021276 Vd NA 0.5453 L/kg 1compartment NA NA Rat Human -DTXSID8021276 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021276 TK.Half.Life NA 2.655 hours 1compartment NA NA Rat Human -DTXSID8021276 Css NA 0.4405 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021276 Css NA 1.82 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021276 Css NA 0.3104 mg/L PBTK NA 50% Rat Human -DTXSID8021276 Css NA 1.07 mg/L PBTK NA 95% Rat Human -DTXSID8021278 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021278 Fup NA 0.8512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021278 Vd NA 2.469 L/kg 1compartment NA NA Human Human -DTXSID8021278 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8021278 TK.Half.Life NA 18.79 hours 1compartment NA NA Human Human -DTXSID8021278 Css NA 0.7313 mg/L 3compartmentss NA 50% Human Human -DTXSID8021278 Css NA 5.248 mg/L 3compartmentss NA 95% Human Human -DTXSID8021278 Css NA 0.7886 mg/L PBTK NA 50% Human Human -DTXSID8021278 Css NA 3.767 mg/L PBTK NA 95% Human Human -DTXSID8021278 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021278 Fup NA 0.8512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021278 Vd NA 2.511 L/kg 1compartment NA NA Rat Human +DTXSID8021272 TK.Half.Life NA 3.31 hours 1compartment NA NA Rat Human +DTXSID8021272 Css NA 9.095e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021272 Css NA 0.002275 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021272 Css NA 6.174e-05 mg/L PBTK NA 50% Rat Human +DTXSID8021272 Css NA 0.001419 mg/L PBTK NA 95% Rat Human +DTXSID8021278 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021278 Fup 0.621 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021278 Vd NA 1.019 L/kg 1compartment NA NA Human Human +DTXSID8021278 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8021278 TK.Half.Life NA 1.494 hours 1compartment NA NA Human Human +DTXSID8021278 Css NA 0.09044 mg/L 3compartmentss NA 50% Human Human +DTXSID8021278 Css NA 0.8649 mg/L 3compartmentss NA 95% Human Human +DTXSID8021278 Css NA 0.07495 mg/L PBTK NA 50% Human Human +DTXSID8021278 Css NA 0.5836 mg/L PBTK NA 95% Human Human +DTXSID8021278 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021278 Fup 0.621 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021278 Vd NA 0.9434 L/kg 1compartment NA NA Rat Human DTXSID8021278 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021278 TK.Half.Life NA 6.508 hours 1compartment NA NA Rat Human -DTXSID8021278 Css NA 0.1812 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021278 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021278 Css NA 0.195 mg/L PBTK NA 50% Rat Human -DTXSID8021278 Css NA 0.8771 mg/L PBTK NA 95% Rat Human +DTXSID8021278 TK.Half.Life NA 0.7321 hours 1compartment NA NA Rat Human +DTXSID8021278 Css NA 0.004096 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021278 Css NA 0.04209 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021278 Css NA 0.003424 mg/L PBTK NA 50% Rat Human +DTXSID8021278 Css NA 0.02797 mg/L PBTK NA 95% Rat Human DTXSID8021301 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8021301 Fup 0.0012 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8021301 Vd NA 0.8323 L/kg 1compartment NA NA Human Human -DTXSID8021301 Days.Css NA 1283 Days PBTK NA NA Human Human -DTXSID8021301 TK.Half.Life NA 4690 hours 1compartment NA NA Human Human -DTXSID8021301 Css NA 583.6 mg/L 3compartmentss NA 50% Human Human -DTXSID8021301 Css NA 3270 mg/L 3compartmentss NA 95% Human Human -DTXSID8021301 Css NA 361.8 mg/L PBTK NA 50% Human Human -DTXSID8021301 Css NA 1931 mg/L PBTK NA 95% Human Human +DTXSID8021301 Vd NA 0.1675 L/kg 1compartment NA NA Human Human +DTXSID8021301 Days.Css NA 240 Days PBTK NA NA Human Human +DTXSID8021301 TK.Half.Life NA 902.8 hours 1compartment NA NA Human Human +DTXSID8021301 Css NA 577.8 mg/L 3compartmentss NA 50% Human Human +DTXSID8021301 Css NA 3153 mg/L 3compartmentss NA 95% Human Human +DTXSID8021301 Css NA 335 mg/L PBTK NA 50% Human Human +DTXSID8021301 Css NA 1817 mg/L PBTK NA 95% Human Human DTXSID8021301 Clint 23.6 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID8021301 Fup 0.0075 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID8021301 Vd NA 1.909 L/kg 1compartment NA NA Rat Rat +DTXSID8021301 Vd NA 0.1998 L/kg 1compartment NA NA Rat Rat DTXSID8021301 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8021301 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Rat -DTXSID8021301 Css NA 0.05662 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8021301 Css NA 0.4842 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8021301 Css NA 0.03801 mg/L PBTK NA 50% Rat Rat -DTXSID8021301 Css NA 0.2965 mg/L PBTK NA 95% Rat Rat -DTXSID8021305 Clint NA 0.9168 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021305 Fup NA 0.6688 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021305 Vd NA 0.4423 L/kg 1compartment NA NA Human Human +DTXSID8021301 TK.Half.Life NA 3.016 hours 1compartment NA NA Rat Rat +DTXSID8021301 Css NA 0.532 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8021301 Css NA 4.209 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8021301 Css NA 0.2999 mg/L PBTK NA 50% Rat Rat +DTXSID8021301 Css NA 2.355 mg/L PBTK NA 95% Rat Rat +DTXSID8021305 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021305 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021305 Vd NA 0.4129 L/kg 1compartment NA NA Human Human DTXSID8021305 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021305 TK.Half.Life NA 1.81 hours 1compartment NA NA Human Human -DTXSID8021305 Css NA 0.4996 mg/L 3compartmentss NA 50% Human Human -DTXSID8021305 Css NA 3.266 mg/L 3compartmentss NA 95% Human Human -DTXSID8021305 Css NA 0.3638 mg/L PBTK NA 50% Human Human -DTXSID8021305 Css NA 2.01 mg/L PBTK NA 95% Human Human -DTXSID8021305 Clint NA 0.9168 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021305 Fup NA 0.6688 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021305 Vd NA 0.4576 L/kg 1compartment NA NA Rat Human +DTXSID8021305 TK.Half.Life NA 4.575 hours 1compartment NA NA Human Human +DTXSID8021305 Css NA 1.374 mg/L 3compartmentss NA 50% Human Human +DTXSID8021305 Css NA 8.735 mg/L 3compartmentss NA 95% Human Human +DTXSID8021305 Css NA 0.9796 mg/L PBTK NA 50% Human Human +DTXSID8021305 Css NA 5.321 mg/L PBTK NA 95% Human Human +DTXSID8021305 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021305 Fup 0.584 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021305 Vd NA 0.4267 L/kg 1compartment NA NA Rat Human DTXSID8021305 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021305 TK.Half.Life NA 0.8928 hours 1compartment NA NA Rat Human -DTXSID8021305 Css NA 0.1897 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021305 Css NA 1.153 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021305 Css NA 0.1323 mg/L PBTK NA 50% Rat Human -DTXSID8021305 Css NA 0.6633 mg/L PBTK NA 95% Rat Human +DTXSID8021305 TK.Half.Life NA 1.611 hours 1compartment NA NA Rat Human +DTXSID8021305 Css NA 0.08355 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021305 Css NA 0.4863 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021305 Css NA 0.05888 mg/L PBTK NA 50% Rat Human +DTXSID8021305 Css NA 0.2866 mg/L PBTK NA 95% Rat Human DTXSID8021309 Clint 2.336 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8021309 Fup 0.017 NA NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8021309 Vd NA 0.383 L/kg 1compartment NA NA Human Human DTXSID8021309 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID8021309 TK.Half.Life NA 28.62 hours 1compartment NA NA Human Human -DTXSID8021309 Css NA 13.47 mg/L 3compartmentss NA 50% Human Human -DTXSID8021309 Css NA 103.3 mg/L 3compartmentss NA 95% Human Human -DTXSID8021309 Css NA 8.022 mg/L PBTK NA 50% Human Human -DTXSID8021309 Css NA 59.7 mg/L PBTK NA 95% Human Human +DTXSID8021309 Css NA 13.17 mg/L 3compartmentss NA 50% Human Human +DTXSID8021309 Css NA 99.59 mg/L 3compartmentss NA 95% Human Human +DTXSID8021309 Css NA 7.816 mg/L PBTK NA 50% Human Human +DTXSID8021309 Css NA 58.46 mg/L PBTK NA 95% Human Human DTXSID8021309 Clint 2.336 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID8021309 Fup 0.017 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID8021309 Vd NA 0.3105 L/kg 1compartment NA NA Rat Human DTXSID8021309 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID8021309 TK.Half.Life NA 13.3 hours 1compartment NA NA Rat Human -DTXSID8021309 Css NA 6.528 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021309 Css NA 39.09 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021309 Css NA 3.606 mg/L PBTK NA 50% Rat Human -DTXSID8021309 Css NA 21.2 mg/L PBTK NA 95% Rat Human -DTXSID8021351 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021351 Fup NA 0.2407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021351 Vd NA 0.3128 L/kg 1compartment NA NA Human Human -DTXSID8021351 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021351 TK.Half.Life NA 8.407 hours 1compartment NA NA Human Human -DTXSID8021351 Css NA 3.322 mg/L 3compartmentss NA 50% Human Human -DTXSID8021351 Css NA 12.21 mg/L 3compartmentss NA 95% Human Human -DTXSID8021351 Css NA 2.18 mg/L PBTK NA 50% Human Human -DTXSID8021351 Css NA 7.434 mg/L PBTK NA 95% Human Human -DTXSID8021351 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021351 Fup NA 0.2407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021351 Vd NA 0.3349 L/kg 1compartment NA NA Rat Human -DTXSID8021351 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021351 TK.Half.Life NA 3.068 hours 1compartment NA NA Rat Human -DTXSID8021351 Css NA 0.9372 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021351 Css NA 2.819 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021351 Css NA 0.5772 mg/L PBTK NA 50% Rat Human -DTXSID8021351 Css NA 1.6 mg/L PBTK NA 95% Rat Human +DTXSID8021309 Css NA 1.47 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021309 Css NA 8.943 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021309 Css NA 0.8389 mg/L PBTK NA 50% Rat Human +DTXSID8021309 Css NA 5.024 mg/L PBTK NA 95% Rat Human DTXSID8021359 Clint 1.324 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8021359 Fup 0.04 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID8021359 Vd NA 0.1987 L/kg 1compartment NA NA Human Human DTXSID8021359 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID8021359 TK.Half.Life NA 10.12 hours 1compartment NA NA Human Human -DTXSID8021359 Css NA 6.894 mg/L 3compartmentss NA 50% Human Human -DTXSID8021359 Css NA 50.28 mg/L 3compartmentss NA 95% Human Human -DTXSID8021359 Css NA 4.655 mg/L PBTK NA 50% Human Human -DTXSID8021359 Css NA 30.56 mg/L PBTK NA 95% Human Human +DTXSID8021359 Css NA 7.786 mg/L 3compartmentss NA 50% Human Human +DTXSID8021359 Css NA 48.65 mg/L 3compartmentss NA 95% Human Human +DTXSID8021359 Css NA 5.292 mg/L PBTK NA 50% Human Human +DTXSID8021359 Css NA 33.08 mg/L PBTK NA 95% Human Human DTXSID8021359 Clint 2.042 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8021359 Fup 0.0071 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID8021359 Vd NA 0.1643 L/kg 1compartment NA NA Rat Rat +DTXSID8021359 Vd 0.2 0.1643 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID8021359 Days.Css NA 2 Days PBTK NA NA Rat Rat -DTXSID8021359 TK.Half.Life NA 19.28 hours 1compartment NA NA Rat Rat -DTXSID8021359 Css NA 15.22 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8021359 Css NA 103.6 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8021359 Css NA 9.721 mg/L PBTK NA 50% Rat Rat -DTXSID8021359 Css NA 57.83 mg/L PBTK NA 95% Rat Rat -DTXSID8021484 Clint NA 0.07389 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021484 Fup NA 0.2213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021484 Vd NA 0.4081 L/kg 1compartment NA NA Human Human +DTXSID8021359 TK.Half.Life 3 19.28 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID8021359 Css 0.92 3.244 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID8021359 Css 0.92 19.05 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID8021359 Css 0.92 2.284 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID8021359 Css 0.92 13.41 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID8021430 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021430 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8021430 Vd NA 3.822 L/kg 1compartment NA NA Human Human +DTXSID8021430 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8021430 TK.Half.Life NA 4.542 hours 1compartment NA NA Human Human +DTXSID8021430 Css NA 0.02794 mg/L 3compartmentss NA 50% Human Human +DTXSID8021430 Css NA 0.3739 mg/L 3compartmentss NA 95% Human Human +DTXSID8021430 Css NA 0.03198 mg/L PBTK NA 50% Human Human +DTXSID8021430 Css NA 0.3154 mg/L PBTK NA 95% Human Human +DTXSID8021430 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021430 Fup 0.14 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8021430 Vd NA 3.861 L/kg 1compartment NA NA Rat Human +DTXSID8021430 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8021430 TK.Half.Life NA 2.681 hours 1compartment NA NA Rat Human +DTXSID8021430 Css NA 0.0002543 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021430 Css NA 0.00303 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021430 Css NA 0.0002869 mg/L PBTK NA 50% Rat Human +DTXSID8021430 Css NA 0.002531 mg/L PBTK NA 95% Rat Human +DTXSID8021480 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021480 Fup 0.28 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8021480 Vd NA 1.379 L/kg 1compartment NA NA Human Human +DTXSID8021480 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8021480 TK.Half.Life NA 32.45 hours 1compartment NA NA Human Human +DTXSID8021480 Css NA 1.142 mg/L 3compartmentss NA 50% Human Human +DTXSID8021480 Css NA 5.208 mg/L 3compartmentss NA 95% Human Human +DTXSID8021480 Css NA 0.9222 mg/L PBTK NA 50% Human Human +DTXSID8021480 Css NA 3.509 mg/L PBTK NA 95% Human Human +DTXSID8021480 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021480 Fup 0.28 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8021480 Vd NA 1.357 L/kg 1compartment NA NA Rat Human +DTXSID8021480 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8021480 TK.Half.Life NA 10.73 hours 1compartment NA NA Rat Human +DTXSID8021480 Css NA 0.005664 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021480 Css NA 0.02455 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021480 Css NA 0.004441 mg/L PBTK NA 50% Rat Human +DTXSID8021480 Css NA 0.01586 mg/L PBTK NA 95% Rat Human +DTXSID8021484 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021484 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021484 Vd NA 0.5011 L/kg 1compartment NA NA Human Human DTXSID8021484 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8021484 TK.Half.Life NA 10.6 hours 1compartment NA NA Human Human -DTXSID8021484 Css NA 3.087 mg/L 3compartmentss NA 50% Human Human -DTXSID8021484 Css NA 11.87 mg/L 3compartmentss NA 95% Human Human -DTXSID8021484 Css NA 2.086 mg/L PBTK NA 50% Human Human -DTXSID8021484 Css NA 7.27 mg/L PBTK NA 95% Human Human -DTXSID8021484 Clint NA 0.07389 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021484 Fup NA 0.2213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021484 Vd NA 0.413 L/kg 1compartment NA NA Rat Human +DTXSID8021484 TK.Half.Life NA 9.853 hours 1compartment NA NA Human Human +DTXSID8021484 Css NA 1.191 mg/L 3compartmentss NA 50% Human Human +DTXSID8021484 Css NA 5.152 mg/L 3compartmentss NA 95% Human Human +DTXSID8021484 Css NA 0.8616 mg/L PBTK NA 50% Human Human +DTXSID8021484 Css NA 3.286 mg/L PBTK NA 95% Human Human +DTXSID8021484 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021484 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021484 Vd NA 0.5089 L/kg 1compartment NA NA Rat Human DTXSID8021484 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021484 TK.Half.Life NA 3.879 hours 1compartment NA NA Rat Human -DTXSID8021484 Css NA 0.9224 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021484 Css NA 2.949 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021484 Css NA 0.5906 mg/L PBTK NA 50% Rat Human -DTXSID8021484 Css NA 1.693 mg/L PBTK NA 95% Rat Human +DTXSID8021484 TK.Half.Life NA 3.411 hours 1compartment NA NA Rat Human +DTXSID8021484 Css NA 0.006362 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021484 Css NA 0.02888 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021484 Css NA 0.00441 mg/L PBTK NA 50% Rat Human +DTXSID8021484 Css NA 0.01755 mg/L PBTK NA 95% Rat Human DTXSID8021488 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021488 Fup NA 0.2459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021488 Vd NA 0.4471 L/kg 1compartment NA NA Human Human +DTXSID8021488 Vd NA 0.4816 L/kg 1compartment NA NA Human Human DTXSID8021488 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8021488 TK.Half.Life NA 11.76 hours 1compartment NA NA Human Human -DTXSID8021488 Css NA 3.134 mg/L 3compartmentss NA 50% Human Human -DTXSID8021488 Css NA 11.49 mg/L 3compartmentss NA 95% Human Human -DTXSID8021488 Css NA 2.152 mg/L PBTK NA 50% Human Human -DTXSID8021488 Css NA 7.217 mg/L PBTK NA 95% Human Human +DTXSID8021488 TK.Half.Life NA 12.67 hours 1compartment NA NA Human Human +DTXSID8021488 Css NA 1.625 mg/L 3compartmentss NA 50% Human Human +DTXSID8021488 Css NA 6.839 mg/L 3compartmentss NA 95% Human Human +DTXSID8021488 Css NA 1.148 mg/L PBTK NA 50% Human Human +DTXSID8021488 Css NA 4.287 mg/L PBTK NA 95% Human Human DTXSID8021488 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021488 Fup NA 0.2459 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021488 Vd NA 0.4513 L/kg 1compartment NA NA Rat Human +DTXSID8021488 Vd NA 0.4839 L/kg 1compartment NA NA Rat Human DTXSID8021488 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021488 TK.Half.Life NA 4.046 hours 1compartment NA NA Rat Human -DTXSID8021488 Css NA 0.8608 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021488 Css NA 2.715 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021488 Css NA 0.5649 mg/L PBTK NA 50% Rat Human -DTXSID8021488 Css NA 1.579 mg/L PBTK NA 95% Rat Human -DTXSID8021515 Clint NA 0.001199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021515 Fup NA 0.4361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021515 Vd NA 0.4203 L/kg 1compartment NA NA Human Human +DTXSID8021488 TK.Half.Life NA 4.338 hours 1compartment NA NA Rat Human +DTXSID8021488 Css NA 0.00878 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021488 Css NA 0.03588 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021488 Css NA 0.005902 mg/L PBTK NA 50% Rat Human +DTXSID8021488 Css NA 0.02179 mg/L PBTK NA 95% Rat Human +DTXSID8021515 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021515 Fup 0.593 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021515 Vd NA 0.4932 L/kg 1compartment NA NA Human Human DTXSID8021515 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021515 TK.Half.Life NA 6.222 hours 1compartment NA NA Human Human -DTXSID8021515 Css NA 1.749 mg/L 3compartmentss NA 50% Human Human -DTXSID8021515 Css NA 8.007 mg/L 3compartmentss NA 95% Human Human -DTXSID8021515 Css NA 1.247 mg/L PBTK NA 50% Human Human -DTXSID8021515 Css NA 5.007 mg/L PBTK NA 95% Human Human -DTXSID8021515 Clint NA 0.001199 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021515 Fup NA 0.4361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021515 Vd NA 0.4262 L/kg 1compartment NA NA Rat Human +DTXSID8021515 TK.Half.Life NA 5.382 hours 1compartment NA NA Human Human +DTXSID8021515 Css NA 1.113 mg/L 3compartmentss NA 50% Human Human +DTXSID8021515 Css NA 7.323 mg/L 3compartmentss NA 95% Human Human +DTXSID8021515 Css NA 0.8402 mg/L PBTK NA 50% Human Human +DTXSID8021515 Css NA 4.49 mg/L PBTK NA 95% Human Human +DTXSID8021515 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021515 Fup 0.593 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021515 Vd NA 0.5014 L/kg 1compartment NA NA Rat Human DTXSID8021515 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021515 TK.Half.Life NA 2.153 hours 1compartment NA NA Rat Human -DTXSID8021515 Css NA 0.473 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021515 Css NA 1.863 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021515 Css NA 0.3214 mg/L PBTK NA 50% Rat Human -DTXSID8021515 Css NA 1.083 mg/L PBTK NA 95% Rat Human +DTXSID8021515 TK.Half.Life NA 1.864 hours 1compartment NA NA Rat Human +DTXSID8021515 Css NA 0.02099 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021515 Css NA 0.1853 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021515 Css NA 0.01515 mg/L PBTK NA 50% Rat Human +DTXSID8021515 Css NA 0.1135 mg/L PBTK NA 95% Rat Human DTXSID8021517 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021517 Fup NA 0.5925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021517 Vd NA 0.5434 L/kg 1compartment NA NA Human Human DTXSID8021517 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8021517 TK.Half.Life NA 5.934 hours 1compartment NA NA Human Human -DTXSID8021517 Css NA 1.282 mg/L 3compartmentss NA 50% Human Human -DTXSID8021517 Css NA 8.733 mg/L 3compartmentss NA 95% Human Human -DTXSID8021517 Css NA 0.9898 mg/L PBTK NA 50% Human Human -DTXSID8021517 Css NA 5.464 mg/L PBTK NA 95% Human Human +DTXSID8021517 Css NA 1.096 mg/L 3compartmentss NA 50% Human Human +DTXSID8021517 Css NA 7.63 mg/L 3compartmentss NA 95% Human Human +DTXSID8021517 Css NA 0.8472 mg/L PBTK NA 50% Human Human +DTXSID8021517 Css NA 4.727 mg/L PBTK NA 95% Human Human DTXSID8021517 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021517 Fup NA 0.5925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021517 Vd NA 0.566 L/kg 1compartment NA NA Rat Human DTXSID8021517 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8021517 TK.Half.Life NA 2.106 hours 1compartment NA NA Rat Human -DTXSID8021517 Css NA 0.3387 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021517 Css NA 2.082 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021517 Css NA 0.2496 mg/L PBTK NA 50% Rat Human -DTXSID8021517 Css NA 1.209 mg/L PBTK NA 95% Rat Human -DTXSID8021519 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021519 Fup NA 0.6673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021519 Vd NA 0.8706 L/kg 1compartment NA NA Human Human +DTXSID8021517 Css NA 0.02086 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021517 Css NA 0.1762 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021517 Css NA 0.0154 mg/L PBTK NA 50% Rat Human +DTXSID8021517 Css NA 0.1088 mg/L PBTK NA 95% Rat Human +DTXSID8021519 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021519 Fup 0.613 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021519 Vd NA 0.8272 L/kg 1compartment NA NA Human Human DTXSID8021519 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021519 TK.Half.Life NA 8.585 hours 1compartment NA NA Human Human -DTXSID8021519 Css NA 1.105 mg/L 3compartmentss NA 50% Human Human -DTXSID8021519 Css NA 7.259 mg/L 3compartmentss NA 95% Human Human -DTXSID8021519 Css NA 0.9195 mg/L PBTK NA 50% Human Human -DTXSID8021519 Css NA 4.645 mg/L PBTK NA 95% Human Human -DTXSID8021519 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021519 Fup NA 0.6673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021519 Vd NA 0.8497 L/kg 1compartment NA NA Rat Human +DTXSID8021519 TK.Half.Life NA 8.867 hours 1compartment NA NA Human Human +DTXSID8021519 Css NA 1.152 mg/L 3compartmentss NA 50% Human Human +DTXSID8021519 Css NA 7.938 mg/L 3compartmentss NA 95% Human Human +DTXSID8021519 Css NA 0.9489 mg/L PBTK NA 50% Human Human +DTXSID8021519 Css NA 5.086 mg/L PBTK NA 95% Human Human +DTXSID8021519 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021519 Fup 0.613 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021519 Vd NA 0.8074 L/kg 1compartment NA NA Rat Human DTXSID8021519 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021519 TK.Half.Life NA 2.819 hours 1compartment NA NA Rat Human -DTXSID8021519 Css NA 0.2844 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021519 Css NA 1.825 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021519 Css NA 0.23 mg/L PBTK NA 50% Rat Human -DTXSID8021519 Css NA 1.089 mg/L PBTK NA 95% Rat Human +DTXSID8021519 TK.Half.Life NA 2.915 hours 1compartment NA NA Rat Human +DTXSID8021519 Css NA 0.071 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021519 Css NA 0.4656 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021519 Css NA 0.05808 mg/L PBTK NA 50% Rat Human +DTXSID8021519 Css NA 0.285 mg/L PBTK NA 95% Rat Human DTXSID8021561 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021561 Fup NA 0.9734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021561 Vd NA 0.8816 L/kg 1compartment NA NA Human Human DTXSID8021561 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8021561 TK.Half.Life NA 5.909 hours 1compartment NA NA Human Human -DTXSID8021561 Css NA 0.8321 mg/L 3compartmentss NA 50% Human Human -DTXSID8021561 Css NA 3.157 mg/L 3compartmentss NA 95% Human Human -DTXSID8021561 Css NA 0.7088 mg/L PBTK NA 50% Human Human -DTXSID8021561 Css NA 2.245 mg/L PBTK NA 95% Human Human +DTXSID8021561 Css NA 0.715 mg/L 3compartmentss NA 50% Human Human +DTXSID8021561 Css NA 2.804 mg/L 3compartmentss NA 95% Human Human +DTXSID8021561 Css NA 0.6073 mg/L PBTK NA 50% Human Human +DTXSID8021561 Css NA 1.949 mg/L PBTK NA 95% Human Human DTXSID8021561 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021561 Fup NA 0.9734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021561 Vd NA 0.8878 L/kg 1compartment NA NA Rat Human DTXSID8021561 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8021561 TK.Half.Life NA 2.015 hours 1compartment NA NA Rat Human -DTXSID8021561 Css NA 0.2152 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021561 Css NA 0.7477 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021561 Css NA 0.1792 mg/L PBTK NA 50% Rat Human -DTXSID8021561 Css NA 0.4849 mg/L PBTK NA 95% Rat Human -DTXSID8021563 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021563 Fup NA 0.0391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021563 Vd NA 0.5488 L/kg 1compartment NA NA Human Human -DTXSID8021563 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID8021563 TK.Half.Life NA 94.94 hours 1compartment NA NA Human Human -DTXSID8021563 Css NA 29.66 mg/L 3compartmentss NA 50% Human Human -DTXSID8021563 Css NA 164.2 mg/L 3compartmentss NA 95% Human Human -DTXSID8021563 Css NA 17.92 mg/L PBTK NA 50% Human Human -DTXSID8021563 Css NA 95.13 mg/L PBTK NA 95% Human Human -DTXSID8021563 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021563 Fup NA 0.0391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021563 Vd NA 0.4316 L/kg 1compartment NA NA Rat Human -DTXSID8021563 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID8021563 TK.Half.Life NA 24.61 hours 1compartment NA NA Rat Human -DTXSID8021563 Css NA 8.342 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021563 Css NA 40.56 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021563 Css NA 4.705 mg/L PBTK NA 50% Rat Human -DTXSID8021563 Css NA 22.11 mg/L PBTK NA 95% Rat Human -DTXSID8021640 Clint NA 2.395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021640 Fup NA 0.373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021640 Vd NA 0.5744 L/kg 1compartment NA NA Human Human +DTXSID8021561 Css NA 0.01297 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021561 Css NA 0.06775 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021561 Css NA 0.0106 mg/L PBTK NA 50% Rat Human +DTXSID8021561 Css NA 0.04919 mg/L PBTK NA 95% Rat Human +DTXSID8021563 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021563 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021563 Vd NA 0.7099 L/kg 1compartment NA NA Human Human +DTXSID8021563 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8021563 TK.Half.Life NA 1.391 hours 1compartment NA NA Human Human +DTXSID8021563 Css NA 0.168 mg/L 3compartmentss NA 50% Human Human +DTXSID8021563 Css NA 1.304 mg/L 3compartmentss NA 95% Human Human +DTXSID8021563 Css NA 0.1095 mg/L PBTK NA 50% Human Human +DTXSID8021563 Css NA 0.8082 mg/L PBTK NA 95% Human Human +DTXSID8021563 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021563 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021563 Vd NA 0.5858 L/kg 1compartment NA NA Rat Human +DTXSID8021563 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8021563 TK.Half.Life NA 0.6371 hours 1compartment NA NA Rat Human +DTXSID8021563 Css NA 0.02136 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021563 Css NA 0.1321 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021563 Css NA 0.01371 mg/L PBTK NA 50% Rat Human +DTXSID8021563 Css NA 0.07961 mg/L PBTK NA 95% Rat Human +DTXSID8021640 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021640 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021640 Vd NA 0.6146 L/kg 1compartment NA NA Human Human DTXSID8021640 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021640 TK.Half.Life NA 2.261 hours 1compartment NA NA Human Human -DTXSID8021640 Css NA 0.3926 mg/L 3compartmentss NA 50% Human Human -DTXSID8021640 Css NA 2.184 mg/L 3compartmentss NA 95% Human Human -DTXSID8021640 Css NA 0.2977 mg/L PBTK NA 50% Human Human -DTXSID8021640 Css NA 1.457 mg/L PBTK NA 95% Human Human -DTXSID8021640 Clint NA 2.395 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021640 Fup NA 0.373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021640 Vd NA 0.5759 L/kg 1compartment NA NA Rat Human +DTXSID8021640 TK.Half.Life NA 9.467 hours 1compartment NA NA Human Human +DTXSID8021640 Css NA 1.586 mg/L 3compartmentss NA 50% Human Human +DTXSID8021640 Css NA 7.206 mg/L 3compartmentss NA 95% Human Human +DTXSID8021640 Css NA 1.241 mg/L PBTK NA 50% Human Human +DTXSID8021640 Css NA 4.743 mg/L PBTK NA 95% Human Human +DTXSID8021640 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021640 Fup 0.42 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021640 Vd NA 0.6166 L/kg 1compartment NA NA Rat Human DTXSID8021640 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021640 TK.Half.Life NA 1.238 hours 1compartment NA NA Rat Human -DTXSID8021640 Css NA 0.1779 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021640 Css NA 0.7897 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021640 Css NA 0.1308 mg/L PBTK NA 50% Rat Human -DTXSID8021640 Css NA 0.478 mg/L PBTK NA 95% Rat Human -DTXSID8021642 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021642 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021642 Vd NA 47.93 L/kg 1compartment NA NA Human Human -DTXSID8021642 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8021642 TK.Half.Life NA 66080 hours 1compartment NA NA Human Human -DTXSID8021642 Css NA 30.25 mg/L 3compartmentss NA 50% Human Human -DTXSID8021642 Css NA 454.9 mg/L 3compartmentss NA 95% Human Human -DTXSID8021642 Css NA 135.5 mg/L PBTK NA 50% Human Human -DTXSID8021642 Css NA 692.5 mg/L PBTK NA 95% Human Human -DTXSID8021642 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021642 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021642 Vd NA 40.42 L/kg 1compartment NA NA Rat Human -DTXSID8021642 Days.Css NA 5257 Days PBTK NA NA Rat Human -DTXSID8021642 TK.Half.Life NA 15470 hours 1compartment NA NA Rat Human -DTXSID8021642 Css NA 7.517 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021642 Css NA 108.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021642 Css NA 35.73 mg/L PBTK NA 50% Rat Human -DTXSID8021642 Css NA 160 mg/L PBTK NA 95% Rat Human -DTXSID8021644 Clint NA 1.438 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021644 Fup NA 0.4678 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021644 Vd NA 0.5757 L/kg 1compartment NA NA Human Human +DTXSID8021640 TK.Half.Life NA 3.237 hours 1compartment NA NA Rat Human +DTXSID8021640 Css NA 0.09944 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021640 Css NA 0.401 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021640 Css NA 0.07773 mg/L PBTK NA 50% Rat Human +DTXSID8021640 Css NA 0.2517 mg/L PBTK NA 95% Rat Human +DTXSID8021642 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021642 Fup 0.0208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021642 Vd NA 88.84 L/kg 1compartment NA NA Human Human +DTXSID8021642 Days.Css NA 198 Days PBTK NA NA Human Human +DTXSID8021642 TK.Half.Life NA 831.9 hours 1compartment NA NA Human Human +DTXSID8021642 Css NA 0.0575 mg/L 3compartmentss NA 50% Human Human +DTXSID8021642 Css NA 0.994 mg/L 3compartmentss NA 95% Human Human +DTXSID8021642 Css NA 0.5217 mg/L PBTK NA 50% Human Human +DTXSID8021642 Css NA 4.442 mg/L PBTK NA 95% Human Human +DTXSID8021642 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021642 Fup 0.0208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021642 Vd NA 76.61 L/kg 1compartment NA NA Rat Human +DTXSID8021642 Days.Css NA 126 Days PBTK NA NA Rat Human +DTXSID8021642 TK.Half.Life NA 300.2 hours 1compartment NA NA Rat Human +DTXSID8021642 Css NA 0.0005418 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021642 Css NA 0.00929 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021642 Css NA 0.005383 mg/L PBTK NA 50% Rat Human +DTXSID8021642 Css NA 0.04148 mg/L PBTK NA 95% Rat Human +DTXSID8021644 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021644 Fup 0.603 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021644 Vd NA 0.5907 L/kg 1compartment NA NA Human Human DTXSID8021644 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021644 TK.Half.Life NA 2.537 hours 1compartment NA NA Human Human -DTXSID8021644 Css NA 0.4542 mg/L 3compartmentss NA 50% Human Human -DTXSID8021644 Css NA 2.548 mg/L 3compartmentss NA 95% Human Human -DTXSID8021644 Css NA 0.3518 mg/L PBTK NA 50% Human Human -DTXSID8021644 Css NA 1.65 mg/L PBTK NA 95% Human Human -DTXSID8021644 Clint NA 1.438 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021644 Fup NA 0.4678 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021644 Vd NA 0.5815 L/kg 1compartment NA NA Rat Human +DTXSID8021644 TK.Half.Life NA 6.336 hours 1compartment NA NA Human Human +DTXSID8021644 Css NA 1.209 mg/L 3compartmentss NA 50% Human Human +DTXSID8021644 Css NA 8.14 mg/L 3compartmentss NA 95% Human Human +DTXSID8021644 Css NA 0.9532 mg/L PBTK NA 50% Human Human +DTXSID8021644 Css NA 5.091 mg/L PBTK NA 95% Human Human +DTXSID8021644 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021644 Fup 0.603 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021644 Vd NA 0.6031 L/kg 1compartment NA NA Rat Human DTXSID8021644 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021644 TK.Half.Life NA 1.315 hours 1compartment NA NA Rat Human -DTXSID8021644 Css NA 0.1888 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021644 Css NA 0.9245 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021644 Css NA 0.1412 mg/L PBTK NA 50% Rat Human -DTXSID8021644 Css NA 0.5572 mg/L PBTK NA 95% Rat Human +DTXSID8021644 TK.Half.Life NA 2.205 hours 1compartment NA NA Rat Human +DTXSID8021644 Css NA 0.07356 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021644 Css NA 0.4669 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021644 Css NA 0.0578 mg/L PBTK NA 50% Rat Human +DTXSID8021644 Css NA 0.2824 mg/L PBTK NA 95% Rat Human DTXSID8021646 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8021646 Fup NA 0.7246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021646 Vd NA 0.6232 L/kg 1compartment NA NA Human Human +DTXSID8021646 Vd NA 0.6425 L/kg 1compartment NA NA Human Human DTXSID8021646 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021646 TK.Half.Life NA 5.563 hours 1compartment NA NA Human Human -DTXSID8021646 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human -DTXSID8021646 Css NA 6.657 mg/L 3compartmentss NA 95% Human Human -DTXSID8021646 Css NA 0.86 mg/L PBTK NA 50% Human Human -DTXSID8021646 Css NA 4.229 mg/L PBTK NA 95% Human Human +DTXSID8021646 TK.Half.Life NA 5.738 hours 1compartment NA NA Human Human +DTXSID8021646 Css NA 0.9018 mg/L 3compartmentss NA 50% Human Human +DTXSID8021646 Css NA 5.848 mg/L 3compartmentss NA 95% Human Human +DTXSID8021646 Css NA 0.7311 mg/L PBTK NA 50% Human Human +DTXSID8021646 Css NA 3.712 mg/L PBTK NA 95% Human Human DTXSID8021646 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8021646 Fup NA 0.7246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021646 Vd NA 0.6555 L/kg 1compartment NA NA Rat Human +DTXSID8021646 Vd NA 0.6723 L/kg 1compartment NA NA Rat Human DTXSID8021646 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021646 TK.Half.Life NA 1.995 hours 1compartment NA NA Rat Human -DTXSID8021646 Css NA 0.28 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021646 Css NA 1.693 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021646 Css NA 0.2153 mg/L PBTK NA 50% Rat Human -DTXSID8021646 Css NA 0.998 mg/L PBTK NA 95% Rat Human -DTXSID8021648 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021648 Fup NA 0.5643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021648 Vd NA 0.4024 L/kg 1compartment NA NA Human Human +DTXSID8021646 TK.Half.Life NA 2.046 hours 1compartment NA NA Rat Human +DTXSID8021646 Css NA 0.01758 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021646 Css NA 0.1423 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021646 Css NA 0.0135 mg/L PBTK NA 50% Rat Human +DTXSID8021646 Css NA 0.09085 mg/L PBTK NA 95% Rat Human +DTXSID8021648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021648 Fup 0.829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021648 Vd NA 0.4911 L/kg 1compartment NA NA Human Human DTXSID8021648 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021648 TK.Half.Life NA 4.615 hours 1compartment NA NA Human Human -DTXSID8021648 Css NA 1.437 mg/L 3compartmentss NA 50% Human Human -DTXSID8021648 Css NA 9.204 mg/L 3compartmentss NA 95% Human Human -DTXSID8021648 Css NA 1.029 mg/L PBTK NA 50% Human Human -DTXSID8021648 Css NA 5.592 mg/L PBTK NA 95% Human Human -DTXSID8021648 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021648 Fup NA 0.5643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021648 Vd NA 0.4179 L/kg 1compartment NA NA Rat Human +DTXSID8021648 TK.Half.Life NA 3.832 hours 1compartment NA NA Human Human +DTXSID8021648 Css NA 0.902 mg/L 3compartmentss NA 50% Human Human +DTXSID8021648 Css NA 5.228 mg/L 3compartmentss NA 95% Human Human +DTXSID8021648 Css NA 0.6811 mg/L PBTK NA 50% Human Human +DTXSID8021648 Css NA 3.228 mg/L PBTK NA 95% Human Human +DTXSID8021648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021648 Fup 0.829 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021648 Vd NA 0.5117 L/kg 1compartment NA NA Rat Human DTXSID8021648 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021648 TK.Half.Life NA 1.633 hours 1compartment NA NA Rat Human -DTXSID8021648 Css NA 0.3822 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021648 Css NA 2.306 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021648 Css NA 0.26 mg/L PBTK NA 50% Rat Human -DTXSID8021648 Css NA 1.31 mg/L PBTK NA 95% Rat Human -DTXSID8021690 Clint NA 1.736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021690 Fup NA 0.051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021690 Vd NA 0.7245 L/kg 1compartment NA NA Human Human -DTXSID8021690 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8021690 TK.Half.Life NA 23.89 hours 1compartment NA NA Human Human -DTXSID8021690 Css NA 5.351 mg/L 3compartmentss NA 50% Human Human -DTXSID8021690 Css NA 30.98 mg/L 3compartmentss NA 95% Human Human -DTXSID8021690 Css NA 3.441 mg/L PBTK NA 50% Human Human -DTXSID8021690 Css NA 18.6 mg/L PBTK NA 95% Human Human -DTXSID8021690 Clint NA 1.736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021690 Fup NA 0.051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021690 Vd NA 0.5874 L/kg 1compartment NA NA Rat Human -DTXSID8021690 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8021690 TK.Half.Life NA 10.24 hours 1compartment NA NA Rat Human -DTXSID8021690 Css NA 2.45 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021690 Css NA 11.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021690 Css NA 1.479 mg/L PBTK NA 50% Rat Human -DTXSID8021690 Css NA 6.385 mg/L PBTK NA 95% Rat Human -DTXSID8021721 Clint NA 15.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021721 Fup NA 0.3502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021721 Vd NA 2.417 L/kg 1compartment NA NA Human Human -DTXSID8021721 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021721 TK.Half.Life NA 2.715 hours 1compartment NA NA Human Human -DTXSID8021721 Css NA 0.05554 mg/L 3compartmentss NA 50% Human Human -DTXSID8021721 Css NA 0.443 mg/L 3compartmentss NA 95% Human Human -DTXSID8021721 Css NA 0.057 mg/L PBTK NA 50% Human Human -DTXSID8021721 Css NA 0.3776 mg/L PBTK NA 95% Human Human -DTXSID8021721 Clint NA 15.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021721 Fup NA 0.3502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021721 Vd NA 2.421 L/kg 1compartment NA NA Rat Human +DTXSID8021648 TK.Half.Life NA 1.361 hours 1compartment NA NA Rat Human +DTXSID8021648 Css NA 0.01714 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021648 Css NA 0.1255 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021648 Css NA 0.01237 mg/L PBTK NA 50% Rat Human +DTXSID8021648 Css NA 0.07674 mg/L PBTK NA 95% Rat Human +DTXSID8021690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021690 Fup 0.0598 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021690 Vd NA 0.7876 L/kg 1compartment NA NA Human Human +DTXSID8021690 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8021690 TK.Half.Life NA 2.9 hours 1compartment NA NA Human Human +DTXSID8021690 Css NA 0.4606 mg/L 3compartmentss NA 50% Human Human +DTXSID8021690 Css NA 3.84 mg/L 3compartmentss NA 95% Human Human +DTXSID8021690 Css NA 0.3014 mg/L PBTK NA 50% Human Human +DTXSID8021690 Css NA 2.371 mg/L PBTK NA 95% Human Human +DTXSID8021690 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021690 Fup 0.0598 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021690 Vd NA 0.639 L/kg 1compartment NA NA Rat Human +DTXSID8021690 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8021690 TK.Half.Life NA 1.4 hours 1compartment NA NA Rat Human +DTXSID8021690 Css NA 0.06061 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021690 Css NA 0.3808 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021690 Css NA 0.03853 mg/L PBTK NA 50% Rat Human +DTXSID8021690 Css NA 0.2296 mg/L PBTK NA 95% Rat Human +DTXSID8021721 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021721 Fup 0.522 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021721 Vd NA 1.034 L/kg 1compartment NA NA Human Human +DTXSID8021721 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8021721 TK.Half.Life NA 12.81 hours 1compartment NA NA Human Human +DTXSID8021721 Css NA 1.252 mg/L 3compartmentss NA 50% Human Human +DTXSID8021721 Css NA 7.415 mg/L 3compartmentss NA 95% Human Human +DTXSID8021721 Css NA 1.046 mg/L PBTK NA 50% Human Human +DTXSID8021721 Css NA 4.847 mg/L PBTK NA 95% Human Human +DTXSID8021721 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021721 Fup 0.522 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021721 Vd NA 1.061 L/kg 1compartment NA NA Rat Human DTXSID8021721 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021721 TK.Half.Life NA 1.524 hours 1compartment NA NA Rat Human -DTXSID8021721 Css NA 0.02848 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021721 Css NA 0.186 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021721 Css NA 0.02902 mg/L PBTK NA 50% Rat Human -DTXSID8021721 Css NA 0.1483 mg/L PBTK NA 95% Rat Human -DTXSID8021725 Clint NA 2.249 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021725 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021725 Vd NA 1.516 L/kg 1compartment NA NA Human Human +DTXSID8021721 TK.Half.Life NA 4.481 hours 1compartment NA NA Rat Human +DTXSID8021721 Css NA 0.07705 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021721 Css NA 0.4184 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021721 Css NA 0.06435 mg/L PBTK NA 50% Rat Human +DTXSID8021721 Css NA 0.2619 mg/L PBTK NA 95% Rat Human +DTXSID8021725 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021725 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021725 Vd NA 0.5103 L/kg 1compartment NA NA Human Human DTXSID8021725 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021725 TK.Half.Life NA 2.738 hours 1compartment NA NA Human Human -DTXSID8021725 Css NA 0.1608 mg/L 3compartmentss NA 50% Human Human -DTXSID8021725 Css NA 1.278 mg/L 3compartmentss NA 95% Human Human -DTXSID8021725 Css NA 0.1526 mg/L PBTK NA 50% Human Human -DTXSID8021725 Css NA 0.9613 mg/L PBTK NA 95% Human Human -DTXSID8021725 Clint NA 2.249 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021725 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021725 Vd NA 1.397 L/kg 1compartment NA NA Rat Human +DTXSID8021725 TK.Half.Life NA 0.9009 hours 1compartment NA NA Human Human +DTXSID8021725 Css NA 0.1368 mg/L 3compartmentss NA 50% Human Human +DTXSID8021725 Css NA 0.9864 mg/L 3compartmentss NA 95% Human Human +DTXSID8021725 Css NA 0.1008 mg/L PBTK NA 50% Human Human +DTXSID8021725 Css NA 0.6516 mg/L PBTK NA 95% Human Human +DTXSID8021725 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021725 Fup 0.488 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021725 Vd NA 0.5342 L/kg 1compartment NA NA Rat Human DTXSID8021725 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021725 TK.Half.Life NA 1.238 hours 1compartment NA NA Rat Human -DTXSID8021725 Css NA 0.06782 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021725 Css NA 0.4763 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021725 Css NA 0.06464 mg/L PBTK NA 50% Rat Human -DTXSID8021725 Css NA 0.309 mg/L PBTK NA 95% Rat Human -DTXSID8021729 Clint NA 10.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021729 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021729 Vd NA 0.1793 L/kg 1compartment NA NA Human Human +DTXSID8021725 TK.Half.Life NA 0.5165 hours 1compartment NA NA Rat Human +DTXSID8021725 Css NA 0.01572 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021725 Css NA 0.09257 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021725 Css NA 0.01157 mg/L PBTK NA 50% Rat Human +DTXSID8021725 Css NA 0.05797 mg/L PBTK NA 95% Rat Human +DTXSID8021729 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021729 Fup 0.0762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021729 Vd NA 0.7065 L/kg 1compartment NA NA Human Human DTXSID8021729 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021729 TK.Half.Life NA 9.241 hours 1compartment NA NA Human Human -DTXSID8021729 Css NA 9.888 mg/L 3compartmentss NA 50% Human Human -DTXSID8021729 Css NA 85.74 mg/L 3compartmentss NA 95% Human Human -DTXSID8021729 Css NA 5.794 mg/L PBTK NA 50% Human Human -DTXSID8021729 Css NA 49.45 mg/L PBTK NA 95% Human Human -DTXSID8021729 Clint NA 10.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021729 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021729 Vd NA 0.1766 L/kg 1compartment NA NA Rat Human +DTXSID8021729 TK.Half.Life NA 5.776 hours 1compartment NA NA Human Human +DTXSID8021729 Css NA 1.231 mg/L 3compartmentss NA 50% Human Human +DTXSID8021729 Css NA 8.252 mg/L 3compartmentss NA 95% Human Human +DTXSID8021729 Css NA 0.7692 mg/L PBTK NA 50% Human Human +DTXSID8021729 Css NA 4.896 mg/L PBTK NA 95% Human Human +DTXSID8021729 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021729 Fup 0.0762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021729 Vd NA 0.5684 L/kg 1compartment NA NA Rat Human DTXSID8021729 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021729 TK.Half.Life NA 5.996 hours 1compartment NA NA Rat Human -DTXSID8021729 Css NA 5.348 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021729 Css NA 38.56 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021729 Css NA 2.908 mg/L PBTK NA 50% Rat Human -DTXSID8021729 Css NA 20.89 mg/L PBTK NA 95% Rat Human +DTXSID8021729 TK.Half.Life NA 2.755 hours 1compartment NA NA Rat Human +DTXSID8021729 Css NA 0.1517 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021729 Css NA 0.7393 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021729 Css NA 0.0921 mg/L PBTK NA 50% Rat Human +DTXSID8021729 Css NA 0.4299 mg/L PBTK NA 95% Rat Human DTXSID8021771 Clint 20.96 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8021771 Fup NA 0.0857 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021771 Vd NA 3.287 L/kg 1compartment NA NA Human Human -DTXSID8021771 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8021771 TK.Half.Life NA 14.92 hours 1compartment NA NA Human Human -DTXSID8021771 Css NA 0.3567 mg/L 3compartmentss NA 50% Human Human -DTXSID8021771 Css NA 2.715 mg/L 3compartmentss NA 95% Human Human -DTXSID8021771 Css NA 0.3954 mg/L PBTK NA 50% Human Human -DTXSID8021771 Css NA 2.584 mg/L PBTK NA 95% Human Human +DTXSID8021771 Fup 0.0124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021771 Vd NA 1.959 L/kg 1compartment NA NA Human Human +DTXSID8021771 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8021771 TK.Half.Life NA 26.36 hours 1compartment NA NA Human Human +DTXSID8021771 Css NA 1.838 mg/L 3compartmentss NA 50% Human Human +DTXSID8021771 Css NA 16.7 mg/L 3compartmentss NA 95% Human Human +DTXSID8021771 Css NA 1.358 mg/L PBTK NA 50% Human Human +DTXSID8021771 Css NA 10.87 mg/L PBTK NA 95% Human Human DTXSID8021771 Clint 55.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID8021771 Fup 0.034 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID8021771 Vd NA 2.084 L/kg 1compartment NA NA Rat Rat +DTXSID8021771 Vd NA 2.186 L/kg 1compartment NA NA Rat Rat DTXSID8021771 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8021771 TK.Half.Life NA 2.799 hours 1compartment NA NA Rat Rat -DTXSID8021771 Css NA 0.1539 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8021771 Css NA 1.067 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8021771 Css NA 0.135 mg/L PBTK NA 50% Rat Rat -DTXSID8021771 Css NA 0.8121 mg/L PBTK NA 95% Rat Rat -DTXSID8021775 Clint NA 3.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021775 Fup NA 0.1654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021775 Vd NA 1.693 L/kg 1compartment NA NA Human Human -DTXSID8021775 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8021775 TK.Half.Life NA 13.95 hours 1compartment NA NA Human Human -DTXSID8021775 Css NA 0.9691 mg/L 3compartmentss NA 50% Human Human -DTXSID8021775 Css NA 4.805 mg/L 3compartmentss NA 95% Human Human -DTXSID8021775 Css NA 0.6819 mg/L PBTK NA 50% Human Human -DTXSID8021775 Css NA 3.175 mg/L PBTK NA 95% Human Human -DTXSID8021775 Clint NA 3.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021775 Fup NA 0.1654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021775 Vd NA 1.311 L/kg 1compartment NA NA Rat Human +DTXSID8021771 TK.Half.Life NA 2.946 hours 1compartment NA NA Rat Rat +DTXSID8021771 Css NA 0.04477 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8021771 Css NA 0.2814 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8021771 Css NA 0.03746 mg/L PBTK NA 50% Rat Rat +DTXSID8021771 Css NA 0.2138 mg/L PBTK NA 95% Rat Rat +DTXSID8021775 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021775 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021775 Vd NA 1.501 L/kg 1compartment NA NA Human Human +DTXSID8021775 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8021775 TK.Half.Life NA 3.639 hours 1compartment NA NA Human Human +DTXSID8021775 Css NA 0.2367 mg/L 3compartmentss NA 50% Human Human +DTXSID8021775 Css NA 1.83 mg/L 3compartmentss NA 95% Human Human +DTXSID8021775 Css NA 0.1606 mg/L PBTK NA 50% Human Human +DTXSID8021775 Css NA 1.146 mg/L PBTK NA 95% Human Human +DTXSID8021775 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021775 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021775 Vd NA 1.159 L/kg 1compartment NA NA Rat Human DTXSID8021775 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021775 TK.Half.Life NA 4.909 hours 1compartment NA NA Rat Human -DTXSID8021775 Css NA 0.473 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021775 Css NA 1.749 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021775 Css NA 0.3188 mg/L PBTK NA 50% Rat Human -DTXSID8021775 Css NA 1.061 mg/L PBTK NA 95% Rat Human -DTXSID8021777 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021777 Fup NA 0.4643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021777 Vd NA 0.4808 L/kg 1compartment NA NA Human Human +DTXSID8021775 TK.Half.Life NA 1.414 hours 1compartment NA NA Rat Human +DTXSID8021775 Css NA 0.03055 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021775 Css NA 0.1835 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021775 Css NA 0.02031 mg/L PBTK NA 50% Rat Human +DTXSID8021775 Css NA 0.1149 mg/L PBTK NA 95% Rat Human +DTXSID8021777 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021777 Fup 0.501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021777 Vd NA 0.5008 L/kg 1compartment NA NA Human Human DTXSID8021777 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021777 TK.Half.Life NA 6.697 hours 1compartment NA NA Human Human -DTXSID8021777 Css NA 1.576 mg/L 3compartmentss NA 50% Human Human -DTXSID8021777 Css NA 7.624 mg/L 3compartmentss NA 95% Human Human -DTXSID8021777 Css NA 1.164 mg/L PBTK NA 50% Human Human -DTXSID8021777 Css NA 4.75 mg/L PBTK NA 95% Human Human -DTXSID8021777 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021777 Fup NA 0.4643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021777 Vd NA 0.5052 L/kg 1compartment NA NA Rat Human +DTXSID8021777 TK.Half.Life NA 6.466 hours 1compartment NA NA Human Human +DTXSID8021777 Css NA 0.8025 mg/L 3compartmentss NA 50% Human Human +DTXSID8021777 Css NA 4.488 mg/L 3compartmentss NA 95% Human Human +DTXSID8021777 Css NA 0.5972 mg/L PBTK NA 50% Human Human +DTXSID8021777 Css NA 2.781 mg/L PBTK NA 95% Human Human +DTXSID8021777 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021777 Fup 0.501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021777 Vd NA 0.5269 L/kg 1compartment NA NA Rat Human DTXSID8021777 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021777 TK.Half.Life NA 2.398 hours 1compartment NA NA Rat Human -DTXSID8021777 Css NA 0.4391 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021777 Css NA 1.763 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021777 Css NA 0.3059 mg/L PBTK NA 50% Rat Human -DTXSID8021777 Css NA 1.034 mg/L PBTK NA 95% Rat Human +DTXSID8021777 TK.Half.Life NA 2.319 hours 1compartment NA NA Rat Human +DTXSID8021777 Css NA 0.004284 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021777 Css NA 0.02406 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021777 Css NA 0.003057 mg/L PBTK NA 50% Rat Human +DTXSID8021777 Css NA 0.01464 mg/L PBTK NA 95% Rat Human +DTXSID8021800 Clint 9.812 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID8021800 Fup 0.04287 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human +DTXSID8021800 Vd NA 1.733 L/kg 1compartment NA NA Human Human +DTXSID8021800 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8021800 TK.Half.Life NA 18.72 hours 1compartment NA NA Human Human +DTXSID8021800 Css NA 1.602 mg/L 3compartmentss NA 50% Human Human +DTXSID8021800 Css NA 11.88 mg/L 3compartmentss NA 95% Human Human +DTXSID8021800 Css NA 1.043 mg/L PBTK NA 50% Human Human +DTXSID8021800 Css NA 7.264 mg/L PBTK NA 95% Human Human +DTXSID8021800 Clint 9.812 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID8021800 Fup 0.04287 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human +DTXSID8021800 Vd NA 1.317 L/kg 1compartment NA NA Rat Human +DTXSID8021800 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8021800 TK.Half.Life NA 6.87 hours 1compartment NA NA Rat Human +DTXSID8021800 Css NA 0.2012 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021800 Css NA 1.151 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021800 Css NA 0.1274 mg/L PBTK NA 50% Rat Human +DTXSID8021800 Css NA 0.6946 mg/L PBTK NA 95% Rat Human DTXSID8021804 Clint 132 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8021804 Fup 0.338 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8021804 Vd NA 1.299 L/kg 1compartment NA NA Human Human DTXSID8021804 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8021804 TK.Half.Life NA 1.037 hours 1compartment NA NA Human Human -DTXSID8021804 Css NA 0.01057 mg/L 3compartmentss NA 50% Human Human -DTXSID8021804 Css NA 0.0664 mg/L 3compartmentss NA 95% Human Human -DTXSID8021804 Css NA 0.008105 mg/L PBTK NA 50% Human Human -DTXSID8021804 Css NA 0.04881 mg/L PBTK NA 95% Human Human +DTXSID8021804 Css NA 0.008491 mg/L 3compartmentss NA 50% Human Human +DTXSID8021804 Css NA 0.06683 mg/L 3compartmentss NA 95% Human Human +DTXSID8021804 Css NA 0.00653 mg/L PBTK NA 50% Human Human +DTXSID8021804 Css NA 0.04909 mg/L PBTK NA 95% Human Human DTXSID8021804 Clint 132 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8021804 Fup 0.338 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8021804 Vd NA 1.082 L/kg 1compartment NA NA Rat Human DTXSID8021804 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8021804 TK.Half.Life NA 0.3905 hours 1compartment NA NA Rat Human -DTXSID8021804 Css NA 0.005666 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021804 Css NA 0.03139 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021804 Css NA 0.004247 mg/L PBTK NA 50% Rat Human -DTXSID8021804 Css NA 0.02201 mg/L PBTK NA 95% Rat Human +DTXSID8021804 Css NA 0.001103 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021804 Css NA 0.007261 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021804 Css NA 0.0008608 mg/L PBTK NA 50% Rat Human +DTXSID8021804 Css NA 0.005483 mg/L PBTK NA 95% Rat Human DTXSID8021808 Clint 27.48 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8021808 Fup 0.38 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8021808 Vd NA 2.02 L/kg 1compartment NA NA Human Human DTXSID8021808 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8021808 TK.Half.Life NA 1.85 hours 1compartment NA NA Human Human -DTXSID8021808 Css NA 0.03694 mg/L 3compartmentss NA 50% Human Human -DTXSID8021808 Css NA 0.3022 mg/L 3compartmentss NA 95% Human Human -DTXSID8021808 Css NA 0.03845 mg/L PBTK NA 50% Human Human -DTXSID8021808 Css NA 0.2589 mg/L PBTK NA 95% Human Human +DTXSID8021808 Css NA 0.03424 mg/L 3compartmentss NA 50% Human Human +DTXSID8021808 Css NA 0.2997 mg/L 3compartmentss NA 95% Human Human +DTXSID8021808 Css NA 0.0358 mg/L PBTK NA 50% Human Human +DTXSID8021808 Css NA 0.2584 mg/L PBTK NA 95% Human Human DTXSID8021808 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID8021808 Fup 0.525 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID8021808 Vd NA 2.157 L/kg 1compartment NA NA Rat Rat DTXSID8021808 Days.Css NA 1 Days PBTK NA NA Rat Rat DTXSID8021808 TK.Half.Life NA 9.792 hours 1compartment NA NA Rat Rat -DTXSID8021808 Css NA 0.3118 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8021808 Css NA 1.724 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8021808 Css NA 0.3657 mg/L PBTK NA 50% Rat Rat -DTXSID8021808 Css NA 1.25 mg/L PBTK NA 95% Rat Rat +DTXSID8021808 Css NA 0.07126 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8021808 Css NA 0.3923 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8021808 Css NA 0.0862 mg/L PBTK NA 50% Rat Rat +DTXSID8021808 Css NA 0.294 mg/L PBTK NA 95% Rat Rat +DTXSID80218303 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80218303 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80218303 Vd NA 1.315 L/kg 1compartment NA NA Human Human +DTXSID80218303 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80218303 TK.Half.Life NA 2.386 hours 1compartment NA NA Human Human +DTXSID80218303 Css NA 0.1194 mg/L 3compartmentss NA 50% Human Human +DTXSID80218303 Css NA 0.9685 mg/L 3compartmentss NA 95% Human Human +DTXSID80218303 Css NA 0.0921 mg/L PBTK NA 50% Human Human +DTXSID80218303 Css NA 0.6511 mg/L PBTK NA 95% Human Human +DTXSID80218303 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80218303 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80218303 Vd NA 1.335 L/kg 1compartment NA NA Rat Human +DTXSID80218303 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80218303 TK.Half.Life NA 0.8881 hours 1compartment NA NA Rat Human +DTXSID80218303 Css NA 0.003816 mg/L 3compartmentss NA 50% Rat Human +DTXSID80218303 Css NA 0.03786 mg/L 3compartmentss NA 95% Rat Human +DTXSID80218303 Css NA 0.003157 mg/L PBTK NA 50% Rat Human +DTXSID80218303 Css NA 0.02585 mg/L PBTK NA 95% Rat Human DTXSID8021856 Clint 26.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8021856 Fup 0.0599 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8021856 Vd NA 1.615 L/kg 1compartment NA NA Human Human +DTXSID8021856 Vd NA 1.601 L/kg 1compartment NA NA Human Human DTXSID8021856 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8021856 TK.Half.Life NA 5.864 hours 1compartment NA NA Human Human -DTXSID8021856 Css NA 0.3732 mg/L 3compartmentss NA 50% Human Human -DTXSID8021856 Css NA 2.58 mg/L 3compartmentss NA 95% Human Human -DTXSID8021856 Css NA 0.2458 mg/L PBTK NA 50% Human Human -DTXSID8021856 Css NA 1.607 mg/L PBTK NA 95% Human Human +DTXSID8021856 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human +DTXSID8021856 Css NA 0.357 mg/L 3compartmentss NA 50% Human Human +DTXSID8021856 Css NA 2.511 mg/L 3compartmentss NA 95% Human Human +DTXSID8021856 Css NA 0.2354 mg/L PBTK NA 50% Human Human +DTXSID8021856 Css NA 1.598 mg/L PBTK NA 95% Human Human DTXSID8021856 Clint 26.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8021856 Fup 0.0599 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8021856 Vd NA 1.219 L/kg 1compartment NA NA Rat Human +DTXSID8021856 Vd NA 1.208 L/kg 1compartment NA NA Rat Human DTXSID8021856 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021856 TK.Half.Life NA 2.194 hours 1compartment NA NA Rat Human -DTXSID8021856 Css NA 0.2118 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021856 Css NA 1.086 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021856 Css NA 0.1322 mg/L PBTK NA 50% Rat Human -DTXSID8021856 Css NA 0.6605 mg/L PBTK NA 95% Rat Human -DTXSID8021931 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021931 Fup NA 0.6618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021931 Vd NA 2.034 L/kg 1compartment NA NA Human Human -DTXSID8021931 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8021931 TK.Half.Life NA 30.18 hours 1compartment NA NA Human Human -DTXSID8021931 Css NA 1.46 mg/L 3compartmentss NA 50% Human Human -DTXSID8021931 Css NA 8.031 mg/L 3compartmentss NA 95% Human Human -DTXSID8021931 Css NA 1.296 mg/L PBTK NA 50% Human Human -DTXSID8021931 Css NA 5.41 mg/L PBTK NA 95% Human Human -DTXSID8021931 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021931 Fup NA 0.6618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021931 Vd NA 1.676 L/kg 1compartment NA NA Rat Human +DTXSID8021856 TK.Half.Life NA 2.176 hours 1compartment NA NA Rat Human +DTXSID8021856 Css NA 0.04712 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021856 Css NA 0.2587 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021856 Css NA 0.03041 mg/L PBTK NA 50% Rat Human +DTXSID8021856 Css NA 0.1611 mg/L PBTK NA 95% Rat Human +DTXSID8021931 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021931 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021931 Vd NA 1.699 L/kg 1compartment NA NA Human Human +DTXSID8021931 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8021931 TK.Half.Life NA 1.903 hours 1compartment NA NA Human Human +DTXSID8021931 Css NA 0.04186 mg/L 3compartmentss NA 50% Human Human +DTXSID8021931 Css NA 0.3631 mg/L 3compartmentss NA 95% Human Human +DTXSID8021931 Css NA 0.03445 mg/L PBTK NA 50% Human Human +DTXSID8021931 Css NA 0.2633 mg/L PBTK NA 95% Human Human +DTXSID8021931 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021931 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021931 Vd NA 1.393 L/kg 1compartment NA NA Rat Human DTXSID8021931 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8021931 TK.Half.Life NA 6.273 hours 1compartment NA NA Rat Human -DTXSID8021931 Css NA 0.3909 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021931 Css NA 2.024 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021931 Css NA 0.3366 mg/L PBTK NA 50% Rat Human -DTXSID8021931 Css NA 1.266 mg/L PBTK NA 95% Rat Human -DTXSID8021937 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021937 Fup NA 0.4759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8021937 Vd NA 2.537 L/kg 1compartment NA NA Human Human -DTXSID8021937 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID8021937 TK.Half.Life NA 90.55 hours 1compartment NA NA Human Human -DTXSID8021937 Css NA 3.752 mg/L 3compartmentss NA 50% Human Human -DTXSID8021937 Css NA 12.84 mg/L 3compartmentss NA 95% Human Human -DTXSID8021937 Css NA 2.993 mg/L PBTK NA 50% Human Human -DTXSID8021937 Css NA 8.847 mg/L PBTK NA 95% Human Human -DTXSID8021937 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021937 Fup NA 0.4759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8021937 Vd NA 1.979 L/kg 1compartment NA NA Rat Human -DTXSID8021937 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID8021937 TK.Half.Life NA 12.73 hours 1compartment NA NA Rat Human -DTXSID8021937 Css NA 0.9965 mg/L 3compartmentss NA 50% Rat Human -DTXSID8021937 Css NA 2.893 mg/L 3compartmentss NA 95% Rat Human -DTXSID8021937 Css NA 0.7719 mg/L PBTK NA 50% Rat Human -DTXSID8021937 Css NA 1.846 mg/L PBTK NA 95% Rat Human +DTXSID8021931 TK.Half.Life NA 0.7348 hours 1compartment NA NA Rat Human +DTXSID8021931 Css NA 0.001483 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021931 Css NA 0.01404 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021931 Css NA 0.001195 mg/L PBTK NA 50% Rat Human +DTXSID8021931 Css NA 0.009874 mg/L PBTK NA 95% Rat Human +DTXSID8021937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021937 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8021937 Vd NA 2.263 L/kg 1compartment NA NA Human Human +DTXSID8021937 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8021937 TK.Half.Life NA 3.784 hours 1compartment NA NA Human Human +DTXSID8021937 Css NA 0.1106 mg/L 3compartmentss NA 50% Human Human +DTXSID8021937 Css NA 0.7125 mg/L 3compartmentss NA 95% Human Human +DTXSID8021937 Css NA 0.08398 mg/L PBTK NA 50% Human Human +DTXSID8021937 Css NA 0.5009 mg/L PBTK NA 95% Human Human +DTXSID8021937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021937 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8021937 Vd NA 1.758 L/kg 1compartment NA NA Rat Human +DTXSID8021937 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8021937 TK.Half.Life NA 1.212 hours 1compartment NA NA Rat Human +DTXSID8021937 Css NA 0.01369 mg/L 3compartmentss NA 50% Rat Human +DTXSID8021937 Css NA 0.06907 mg/L 3compartmentss NA 95% Rat Human +DTXSID8021937 Css NA 0.01042 mg/L PBTK NA 50% Rat Human +DTXSID8021937 Css NA 0.04997 mg/L PBTK NA 95% Rat Human +DTXSID8022036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022036 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022036 Vd NA 1.698 L/kg 1compartment NA NA Human Human +DTXSID8022036 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8022036 TK.Half.Life NA 2.769 hours 1compartment NA NA Human Human +DTXSID8022036 Css NA 0.1074 mg/L 3compartmentss NA 50% Human Human +DTXSID8022036 Css NA 0.7141 mg/L 3compartmentss NA 95% Human Human +DTXSID8022036 Css NA 0.07867 mg/L PBTK NA 50% Human Human +DTXSID8022036 Css NA 0.4953 mg/L PBTK NA 95% Human Human +DTXSID8022036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022036 Fup 0.245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022036 Vd NA 1.338 L/kg 1compartment NA NA Rat Human +DTXSID8022036 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8022036 TK.Half.Life NA 1.039 hours 1compartment NA NA Rat Human +DTXSID8022036 Css NA 0.01321 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022036 Css NA 0.06809 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022036 Css NA 0.009702 mg/L PBTK NA 50% Rat Human +DTXSID8022036 Css NA 0.04741 mg/L PBTK NA 95% Rat Human DTXSID8022080 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8022080 Fup NA 0.0487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8022080 Vd NA 2.924 L/kg 1compartment NA NA Human Human DTXSID8022080 Days.Css NA 651 Days PBTK NA NA Human Human DTXSID8022080 TK.Half.Life NA 3593 hours 1compartment NA NA Human Human -DTXSID8022080 Css NA 148 mg/L 3compartmentss NA 50% Human Human -DTXSID8022080 Css NA 432.6 mg/L 3compartmentss NA 95% Human Human -DTXSID8022080 Css NA 102.2 mg/L PBTK NA 50% Human Human -DTXSID8022080 Css NA 277.8 mg/L PBTK NA 95% Human Human +DTXSID8022080 Css NA 127.3 mg/L 3compartmentss NA 50% Human Human +DTXSID8022080 Css NA 369.9 mg/L 3compartmentss NA 95% Human Human +DTXSID8022080 Css NA 87.48 mg/L PBTK NA 50% Human Human +DTXSID8022080 Css NA 236.4 mg/L PBTK NA 95% Human Human DTXSID8022080 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8022080 Fup NA 0.0487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8022080 Vd NA 2.192 L/kg 1compartment NA NA Rat Human DTXSID8022080 Days.Css NA 244 Days PBTK NA NA Rat Human DTXSID8022080 TK.Half.Life NA 294.3 hours 1compartment NA NA Rat Human -DTXSID8022080 Css NA 40.47 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022080 Css NA 95.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022080 Css NA 26.62 mg/L PBTK NA 50% Rat Human -DTXSID8022080 Css NA 56.57 mg/L PBTK NA 95% Rat Human -DTXSID8022082 Clint NA 0.5204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022082 Fup NA 0.7749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022082 Vd NA 1.03 L/kg 1compartment NA NA Human Human +DTXSID8022080 Css NA 2.228 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022080 Css NA 10.76 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022080 Css NA 1.477 mg/L PBTK NA 50% Rat Human +DTXSID8022080 Css NA 6.894 mg/L PBTK NA 95% Rat Human +DTXSID8022082 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022082 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022082 Vd NA 0.6788 L/kg 1compartment NA NA Human Human DTXSID8022082 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022082 TK.Half.Life NA 4.864 hours 1compartment NA NA Human Human -DTXSID8022082 Css NA 0.5132 mg/L 3compartmentss NA 50% Human Human -DTXSID8022082 Css NA 3.28 mg/L 3compartmentss NA 95% Human Human -DTXSID8022082 Css NA 0.4482 mg/L PBTK NA 50% Human Human -DTXSID8022082 Css NA 2.193 mg/L PBTK NA 95% Human Human -DTXSID8022082 Clint NA 0.5204 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022082 Fup NA 0.7749 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022082 Vd NA 0.9917 L/kg 1compartment NA NA Rat Human +DTXSID8022082 TK.Half.Life NA 0.7793 hours 1compartment NA NA Human Human +DTXSID8022082 Css NA 0.05091 mg/L 3compartmentss NA 50% Human Human +DTXSID8022082 Css NA 0.4145 mg/L 3compartmentss NA 95% Human Human +DTXSID8022082 Css NA 0.03796 mg/L PBTK NA 50% Human Human +DTXSID8022082 Css NA 0.2796 mg/L PBTK NA 95% Human Human +DTXSID8022082 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022082 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022082 Vd NA 0.65 L/kg 1compartment NA NA Rat Human DTXSID8022082 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022082 TK.Half.Life NA 2.02 hours 1compartment NA NA Rat Human -DTXSID8022082 Css NA 0.174 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022082 Css NA 1.158 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022082 Css NA 0.1488 mg/L PBTK NA 50% Rat Human -DTXSID8022082 Css NA 0.7062 mg/L PBTK NA 95% Rat Human -DTXSID8022084 Clint NA 5.435 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022084 Fup NA 0.3291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022084 Vd NA 0.9679 L/kg 1compartment NA NA Human Human +DTXSID8022082 TK.Half.Life NA 0.3855 hours 1compartment NA NA Rat Human +DTXSID8022082 Css NA 0.006332 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022082 Css NA 0.03965 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022082 Css NA 0.004707 mg/L PBTK NA 50% Rat Human +DTXSID8022082 Css NA 0.02593 mg/L PBTK NA 95% Rat Human +DTXSID8022084 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022084 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022084 Vd NA 1.51 L/kg 1compartment NA NA Human Human DTXSID8022084 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022084 TK.Half.Life NA 2.552 hours 1compartment NA NA Human Human -DTXSID8022084 Css NA 0.236 mg/L 3compartmentss NA 50% Human Human -DTXSID8022084 Css NA 1.508 mg/L 3compartmentss NA 95% Human Human -DTXSID8022084 Css NA 0.177 mg/L PBTK NA 50% Human Human -DTXSID8022084 Css NA 1.015 mg/L PBTK NA 95% Human Human -DTXSID8022084 Clint NA 5.435 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022084 Fup NA 0.3291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022084 Vd NA 0.8447 L/kg 1compartment NA NA Rat Human +DTXSID8022084 TK.Half.Life NA 2.76 hours 1compartment NA NA Human Human +DTXSID8022084 Css NA 0.1292 mg/L 3compartmentss NA 50% Human Human +DTXSID8022084 Css NA 0.8678 mg/L 3compartmentss NA 95% Human Human +DTXSID8022084 Css NA 0.09255 mg/L PBTK NA 50% Human Human +DTXSID8022084 Css NA 0.5857 mg/L PBTK NA 95% Human Human +DTXSID8022084 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022084 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022084 Vd NA 1.187 L/kg 1compartment NA NA Rat Human DTXSID8022084 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022084 TK.Half.Life NA 1.221 hours 1compartment NA NA Rat Human -DTXSID8022084 Css NA 0.1186 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022084 Css NA 0.5769 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022084 Css NA 0.08557 mg/L PBTK NA 50% Rat Human -DTXSID8022084 Css NA 0.3627 mg/L PBTK NA 95% Rat Human -DTXSID8022086 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022086 Fup NA 0.6294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022086 Vd NA 0.9446 L/kg 1compartment NA NA Human Human -DTXSID8022086 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8022086 TK.Half.Life NA 9.998 hours 1compartment NA NA Human Human -DTXSID8022086 Css NA 1.139 mg/L 3compartmentss NA 50% Human Human -DTXSID8022086 Css NA 8.044 mg/L 3compartmentss NA 95% Human Human -DTXSID8022086 Css NA 0.9574 mg/L PBTK NA 50% Human Human -DTXSID8022086 Css NA 5.175 mg/L PBTK NA 95% Human Human -DTXSID8022086 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022086 Fup NA 0.6294 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022086 Vd NA 0.9007 L/kg 1compartment NA NA Rat Human +DTXSID8022084 TK.Half.Life NA 1.076 hours 1compartment NA NA Rat Human +DTXSID8022084 Css NA 0.01622 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022084 Css NA 0.08197 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022084 Css NA 0.01148 mg/L PBTK NA 50% Rat Human +DTXSID8022084 Css NA 0.05456 mg/L PBTK NA 95% Rat Human +DTXSID8022086 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022086 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022086 Vd NA 0.7698 L/kg 1compartment NA NA Human Human +DTXSID8022086 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8022086 TK.Half.Life NA 0.8145 hours 1compartment NA NA Human Human +DTXSID8022086 Css NA 0.04352 mg/L 3compartmentss NA 50% Human Human +DTXSID8022086 Css NA 0.3665 mg/L 3compartmentss NA 95% Human Human +DTXSID8022086 Css NA 0.03352 mg/L PBTK NA 50% Human Human +DTXSID8022086 Css NA 0.2535 mg/L PBTK NA 95% Human Human +DTXSID8022086 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022086 Fup 0.441 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022086 Vd NA 0.7309 L/kg 1compartment NA NA Rat Human DTXSID8022086 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022086 TK.Half.Life NA 3.177 hours 1compartment NA NA Rat Human -DTXSID8022086 Css NA 0.3024 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022086 Css NA 1.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022086 Css NA 0.245 mg/L PBTK NA 50% Rat Human -DTXSID8022086 Css NA 1.174 mg/L PBTK NA 95% Rat Human +DTXSID8022086 TK.Half.Life NA 0.3936 hours 1compartment NA NA Rat Human +DTXSID8022086 Css NA 0.005364 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022086 Css NA 0.03605 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022086 Css NA 0.00414 mg/L PBTK NA 50% Rat Human +DTXSID8022086 Css NA 0.02435 mg/L PBTK NA 95% Rat Human DTXSID8022111 Clint 11.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8022111 Fup 0.0713 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8022111 Vd NA 1.762 L/kg 1compartment NA NA Human Human DTXSID8022111 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8022111 TK.Half.Life NA 11.57 hours 1compartment NA NA Human Human -DTXSID8022111 Css NA 0.7371 mg/L 3compartmentss NA 50% Human Human -DTXSID8022111 Css NA 4.611 mg/L 3compartmentss NA 95% Human Human -DTXSID8022111 Css NA 0.4942 mg/L PBTK NA 50% Human Human -DTXSID8022111 Css NA 2.933 mg/L PBTK NA 95% Human Human +DTXSID8022111 Css NA 0.7252 mg/L 3compartmentss NA 50% Human Human +DTXSID8022111 Css NA 4.28 mg/L 3compartmentss NA 95% Human Human +DTXSID8022111 Css NA 0.484 mg/L PBTK NA 50% Human Human +DTXSID8022111 Css NA 2.771 mg/L PBTK NA 95% Human Human DTXSID8022111 Clint 11.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8022111 Fup 0.0713 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8022111 Vd NA 1.33 L/kg 1compartment NA NA Rat Human DTXSID8022111 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8022111 TK.Half.Life NA 4.104 hours 1compartment NA NA Rat Human -DTXSID8022111 Css NA 0.4051 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022111 Css NA 1.85 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022111 Css NA 0.2569 mg/L PBTK NA 50% Rat Human -DTXSID8022111 Css NA 1.116 mg/L PBTK NA 95% Rat Human -DTXSID8022117 Clint NA 112.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8022111 Css NA 0.09043 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022111 Css NA 0.424 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022111 Css NA 0.05967 mg/L PBTK NA 50% Rat Human +DTXSID8022111 Css NA 0.2661 mg/L PBTK NA 95% Rat Human +DTXSID8022117 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8022117 Fup 0.33 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8022117 Vd NA 2.41 L/kg 1compartment NA NA Human Human -DTXSID8022117 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022117 TK.Half.Life NA 1.418 hours 1compartment NA NA Human Human -DTXSID8022117 Css NA 0.007624 mg/L 3compartmentss NA 50% Human Human -DTXSID8022117 Css NA 0.07108 mg/L 3compartmentss NA 95% Human Human -DTXSID8022117 Css NA 0.008194 mg/L PBTK NA 50% Human Human -DTXSID8022117 Css NA 0.06198 mg/L PBTK NA 95% Human Human -DTXSID8022117 Clint NA 112.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8022117 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID8022117 TK.Half.Life NA 47.31 hours 1compartment NA NA Human Human +DTXSID8022117 Css NA 1.454 mg/L 3compartmentss NA 50% Human Human +DTXSID8022117 Css NA 7.214 mg/L 3compartmentss NA 95% Human Human +DTXSID8022117 Css NA 1.558 mg/L PBTK NA 50% Human Human +DTXSID8022117 Css NA 5.574 mg/L PBTK NA 95% Human Human +DTXSID8022117 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8022117 Fup 0.33 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8022117 Vd NA 2.39 L/kg 1compartment NA NA Rat Human -DTXSID8022117 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022117 TK.Half.Life NA 0.6652 hours 1compartment NA NA Rat Human -DTXSID8022117 Css NA 0.004162 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022117 Css NA 0.03157 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022117 Css NA 0.00439 mg/L PBTK NA 50% Rat Human -DTXSID8022117 Css NA 0.02654 mg/L PBTK NA 95% Rat Human +DTXSID8022117 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8022117 TK.Half.Life NA 15.97 hours 1compartment NA NA Rat Human +DTXSID8022117 Css NA 0.0887 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022117 Css NA 0.3963 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022117 Css NA 0.09803 mg/L PBTK NA 50% Rat Human +DTXSID8022117 Css NA 0.2935 mg/L PBTK NA 95% Rat Human DTXSID8022161 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8022161 Fup NA 0.0694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8022161 Vd NA 0.6285 L/kg 1compartment NA NA Human Human DTXSID8022161 Days.Css NA 11 Days PBTK NA NA Human Human DTXSID8022161 TK.Half.Life NA 61.72 hours 1compartment NA NA Human Human -DTXSID8022161 Css NA 15.4 mg/L 3compartmentss NA 50% Human Human -DTXSID8022161 Css NA 68.99 mg/L 3compartmentss NA 95% Human Human -DTXSID8022161 Css NA 9.657 mg/L PBTK NA 50% Human Human -DTXSID8022161 Css NA 40.39 mg/L PBTK NA 95% Human Human +DTXSID8022161 Css NA 13 mg/L 3compartmentss NA 50% Human Human +DTXSID8022161 Css NA 59.39 mg/L 3compartmentss NA 95% Human Human +DTXSID8022161 Css NA 8.166 mg/L PBTK NA 50% Human Human +DTXSID8022161 Css NA 35.05 mg/L PBTK NA 95% Human Human DTXSID8022161 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8022161 Fup NA 0.0694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8022161 Vd NA 0.5083 L/kg 1compartment NA NA Rat Human DTXSID8022161 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID8022161 TK.Half.Life NA 16.36 hours 1compartment NA NA Rat Human -DTXSID8022161 Css NA 4.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022161 Css NA 16.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022161 Css NA 2.569 mg/L PBTK NA 50% Rat Human -DTXSID8022161 Css NA 8.914 mg/L PBTK NA 95% Rat Human -DTXSID8022246 Clint NA 2.159 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022246 Fup NA 0.8128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022246 Vd NA 1.356 L/kg 1compartment NA NA Human Human -DTXSID8022246 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022246 TK.Half.Life NA 2.784 hours 1compartment NA NA Human Human -DTXSID8022246 Css NA 0.201 mg/L 3compartmentss NA 50% Human Human -DTXSID8022246 Css NA 1.444 mg/L 3compartmentss NA 95% Human Human -DTXSID8022246 Css NA 0.1848 mg/L PBTK NA 50% Human Human -DTXSID8022246 Css NA 1.037 mg/L PBTK NA 95% Human Human -DTXSID8022246 Clint NA 2.159 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022246 Fup NA 0.8128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022246 Vd NA 1.383 L/kg 1compartment NA NA Rat Human +DTXSID8022161 Css NA 0.244 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022161 Css NA 1.49 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022161 Css NA 0.1457 mg/L PBTK NA 50% Rat Human +DTXSID8022161 Css NA 0.8637 mg/L PBTK NA 95% Rat Human +DTXSID8022246 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022246 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022246 Vd NA 1.088 L/kg 1compartment NA NA Human Human +DTXSID8022246 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8022246 TK.Half.Life NA 12.14 hours 1compartment NA NA Human Human +DTXSID8022246 Css NA 1.133 mg/L 3compartmentss NA 50% Human Human +DTXSID8022246 Css NA 8.196 mg/L 3compartmentss NA 95% Human Human +DTXSID8022246 Css NA 0.9828 mg/L PBTK NA 50% Human Human +DTXSID8022246 Css NA 5.293 mg/L PBTK NA 95% Human Human +DTXSID8022246 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022246 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022246 Vd NA 1.108 L/kg 1compartment NA NA Rat Human DTXSID8022246 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022246 TK.Half.Life NA 1.495 hours 1compartment NA NA Rat Human -DTXSID8022246 Css NA 0.08302 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022246 Css NA 0.6049 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022246 Css NA 0.07636 mg/L PBTK NA 50% Rat Human -DTXSID8022246 Css NA 0.3806 mg/L PBTK NA 95% Rat Human +DTXSID8022246 TK.Half.Life NA 4.214 hours 1compartment NA NA Rat Human +DTXSID8022246 Css NA 0.06876 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022246 Css NA 0.4572 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022246 Css NA 0.05943 mg/L PBTK NA 50% Rat Human +DTXSID8022246 Css NA 0.285 mg/L PBTK NA 95% Rat Human DTXSID8022292 Clint 68.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8022292 Fup 1.89e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8022292 Vd NA 5.543 L/kg 1compartment NA NA Human Human DTXSID8022292 Days.Css NA 10 Days PBTK NA NA Human Human DTXSID8022292 TK.Half.Life NA 75.06 hours 1compartment NA NA Human Human -DTXSID8022292 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human -DTXSID8022292 Css NA 19.46 mg/L 3compartmentss NA 95% Human Human -DTXSID8022292 Css NA 0.986 mg/L PBTK NA 50% Human Human -DTXSID8022292 Css NA 12.93 mg/L PBTK NA 95% Human Human +DTXSID8022292 Css NA 1.526 mg/L 3compartmentss NA 50% Human Human +DTXSID8022292 Css NA 20.33 mg/L 3compartmentss NA 95% Human Human +DTXSID8022292 Css NA 0.9816 mg/L PBTK NA 50% Human Human +DTXSID8022292 Css NA 13.08 mg/L PBTK NA 95% Human Human DTXSID8022292 Clint 54.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8022292 Fup 0 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID8022292 Css NA 0.9932 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8022292 Css NA 4.252 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8022292 Css 0.0073 0.1889 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID8022292 Css 0.0073 0.9553 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID80222945 Clint 7.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80222945 Fup 0.0459 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80222945 Vd NA 0.7532 L/kg 1compartment NA NA Human Human +DTXSID80222945 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80222945 TK.Half.Life NA 8.297 hours 1compartment NA NA Human Human +DTXSID80222945 Css NA 1.729 mg/L 3compartmentss NA 50% Human Human +DTXSID80222945 Css NA 12.25 mg/L 3compartmentss NA 95% Human Human +DTXSID80222945 Css NA 1.066 mg/L PBTK NA 50% Human Human +DTXSID80222945 Css NA 7.362 mg/L PBTK NA 95% Human Human +DTXSID80222945 Clint 7.5 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80222945 Fup 0.0459 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80222945 Vd NA 0.5849 L/kg 1compartment NA NA Rat Human +DTXSID80222945 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80222945 TK.Half.Life NA 3.862 hours 1compartment NA NA Rat Human +DTXSID80222945 Css NA 0.22 mg/L 3compartmentss NA 50% Rat Human +DTXSID80222945 Css NA 1.11 mg/L 3compartmentss NA 95% Rat Human +DTXSID80222945 Css NA 0.1313 mg/L PBTK NA 50% Rat Human +DTXSID80222945 Css NA 0.6432 mg/L PBTK NA 95% Rat Human DTXSID8022325 Clint 136.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID8022325 Fup NA 0.0175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022325 Vd NA 2.778 L/kg 1compartment NA NA Human Human +DTXSID8022325 Fup 0.00581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022325 Vd NA 1.799 L/kg 1compartment NA NA Human Human DTXSID8022325 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022325 TK.Half.Life NA 9.113 hours 1compartment NA NA Human Human -DTXSID8022325 Css NA 0.3488 mg/L 3compartmentss NA 50% Human Human -DTXSID8022325 Css NA 2.507 mg/L 3compartmentss NA 95% Human Human -DTXSID8022325 Css NA 0.2352 mg/L PBTK NA 50% Human Human -DTXSID8022325 Css NA 1.63 mg/L PBTK NA 95% Human Human +DTXSID8022325 TK.Half.Life NA 7.418 hours 1compartment NA NA Human Human +DTXSID8022325 Css NA 0.5402 mg/L 3compartmentss NA 50% Human Human +DTXSID8022325 Css NA 5.005 mg/L 3compartmentss NA 95% Human Human +DTXSID8022325 Css NA 0.3382 mg/L PBTK NA 50% Human Human +DTXSID8022325 Css NA 3.054 mg/L PBTK NA 95% Human Human DTXSID8022325 Clint 136.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID8022325 Fup NA 0.0175 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022325 Vd NA 2.076 L/kg 1compartment NA NA Rat Human +DTXSID8022325 Fup 0.00581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022325 Vd NA 1.327 L/kg 1compartment NA NA Rat Human DTXSID8022325 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022325 TK.Half.Life NA 2.076 hours 1compartment NA NA Rat Human -DTXSID8022325 Css NA 0.1955 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022325 Css NA 1.218 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022325 Css NA 0.1251 mg/L PBTK NA 50% Rat Human -DTXSID8022325 Css NA 0.7428 mg/L PBTK NA 95% Rat Human -DTXSID8022329 Clint NA 12.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022329 Fup NA 0.0923 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022329 Vd NA 2.282 L/kg 1compartment NA NA Human Human -DTXSID8022329 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8022329 TK.Half.Life NA 14.33 hours 1compartment NA NA Human Human -DTXSID8022329 Css NA 0.7989 mg/L 3compartmentss NA 50% Human Human -DTXSID8022329 Css NA 5.303 mg/L 3compartmentss NA 95% Human Human -DTXSID8022329 Css NA 0.5437 mg/L PBTK NA 50% Human Human -DTXSID8022329 Css NA 3.467 mg/L PBTK NA 95% Human Human -DTXSID8022329 Clint NA 12.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022329 Fup NA 0.0923 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022329 Vd NA 1.721 L/kg 1compartment NA NA Rat Human +DTXSID8022325 TK.Half.Life NA 2.562 hours 1compartment NA NA Rat Human +DTXSID8022325 Css NA 0.07126 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022325 Css NA 0.553 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022325 Css NA 0.04362 mg/L PBTK NA 50% Rat Human +DTXSID8022325 Css NA 0.3292 mg/L PBTK NA 95% Rat Human +DTXSID8022329 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022329 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022329 Vd NA 2.575 L/kg 1compartment NA NA Human Human +DTXSID8022329 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8022329 TK.Half.Life NA 8.889 hours 1compartment NA NA Human Human +DTXSID8022329 Css NA 0.3399 mg/L 3compartmentss NA 50% Human Human +DTXSID8022329 Css NA 2.211 mg/L 3compartmentss NA 95% Human Human +DTXSID8022329 Css NA 0.2404 mg/L PBTK NA 50% Human Human +DTXSID8022329 Css NA 1.494 mg/L PBTK NA 95% Human Human +DTXSID8022329 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022329 Fup 0.155 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022329 Vd NA 1.949 L/kg 1compartment NA NA Rat Human DTXSID8022329 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022329 TK.Half.Life NA 4.111 hours 1compartment NA NA Rat Human -DTXSID8022329 Css NA 0.4348 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022329 Css NA 2.206 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022329 Css NA 0.281 mg/L PBTK NA 50% Rat Human -DTXSID8022329 Css NA 1.358 mg/L PBTK NA 95% Rat Human +DTXSID8022329 TK.Half.Life NA 2.3 hours 1compartment NA NA Rat Human +DTXSID8022329 Css NA 0.04352 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022329 Css NA 0.2296 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022329 Css NA 0.03062 mg/L PBTK NA 50% Rat Human +DTXSID8022329 Css NA 0.1554 mg/L PBTK NA 95% Rat Human +DTXSID80223659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80223659 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80223659 Vd NA 2.914 L/kg 1compartment NA NA Human Human +DTXSID80223659 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID80223659 TK.Half.Life NA 62.11 hours 1compartment NA NA Human Human +DTXSID80223659 Css NA 2.734 mg/L 3compartmentss NA 50% Human Human +DTXSID80223659 Css NA 19.22 mg/L 3compartmentss NA 95% Human Human +DTXSID80223659 Css NA 1.856 mg/L PBTK NA 50% Human Human +DTXSID80223659 Css NA 12.58 mg/L PBTK NA 95% Human Human +DTXSID80223659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80223659 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80223659 Vd NA 2.179 L/kg 1compartment NA NA Rat Human +DTXSID80223659 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID80223659 TK.Half.Life NA 10.8 hours 1compartment NA NA Rat Human +DTXSID80223659 Css NA 0.3548 mg/L 3compartmentss NA 50% Rat Human +DTXSID80223659 Css NA 2.098 mg/L 3compartmentss NA 95% Rat Human +DTXSID80223659 Css NA 0.2384 mg/L PBTK NA 50% Rat Human +DTXSID80223659 Css NA 1.395 mg/L PBTK NA 95% Rat Human DTXSID8022371 Clint 28.83 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.106.011569 NA Human Human DTXSID8022371 Fup 0.057 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8022371 Vd NA 1.969 L/kg 1compartment NA NA Human Human DTXSID8022371 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8022371 TK.Half.Life NA 7.689 hours 1compartment NA NA Human Human -DTXSID8022371 Css NA 0.4825 mg/L 3compartmentss NA 50% Human Human -DTXSID8022371 Css NA 3.426 mg/L 3compartmentss NA 95% Human Human -DTXSID8022371 Css NA 0.3182 mg/L PBTK NA 50% Human Human -DTXSID8022371 Css NA 2.17 mg/L PBTK NA 95% Human Human +DTXSID8022371 Css NA 0.4643 mg/L 3compartmentss NA 50% Human Human +DTXSID8022371 Css NA 3.438 mg/L 3compartmentss NA 95% Human Human +DTXSID8022371 Css NA 0.3056 mg/L PBTK NA 50% Human Human +DTXSID8022371 Css NA 2.18 mg/L PBTK NA 95% Human Human DTXSID8022371 Clint 28.83 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.106.011569 NA Rat Human DTXSID8022371 Fup 0.057 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8022371 Vd NA 1.478 L/kg 1compartment NA NA Rat Human DTXSID8022371 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8022371 TK.Half.Life NA 2.552 hours 1compartment NA NA Rat Human -DTXSID8022371 Css NA 0.271 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022371 Css NA 1.567 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022371 Css NA 0.1683 mg/L PBTK NA 50% Rat Human -DTXSID8022371 Css NA 0.938 mg/L PBTK NA 95% Rat Human +DTXSID8022371 Css NA 0.06078 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022371 Css NA 0.3653 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022371 Css NA 0.03918 mg/L PBTK NA 50% Rat Human +DTXSID8022371 Css NA 0.225 mg/L PBTK NA 95% Rat Human DTXSID8022377 Clint 55.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8022377 Fup 3.98e-05 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8022377 Vd NA 0.2395 L/kg 1compartment NA NA Human Human DTXSID8022377 Days.Css NA 17 Days PBTK NA NA Human Human DTXSID8022377 TK.Half.Life NA 84.48 hours 1compartment NA NA Human Human -DTXSID8022377 Css NA 0.744 mg/L 3compartmentss NA 50% Human Human -DTXSID8022377 Css NA 10.15 mg/L 3compartmentss NA 95% Human Human -DTXSID8022377 Css NA 0.4784 mg/L PBTK NA 50% Human Human -DTXSID8022377 Css NA 6.259 mg/L PBTK NA 95% Human Human +DTXSID8022377 Css NA 0.7307 mg/L 3compartmentss NA 50% Human Human +DTXSID8022377 Css NA 10.24 mg/L 3compartmentss NA 95% Human Human +DTXSID8022377 Css NA 0.467 mg/L PBTK NA 50% Human Human +DTXSID8022377 Css NA 6.166 mg/L PBTK NA 95% Human Human DTXSID8022377 Clint 55.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8022377 Fup 3.98e-05 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8022377 Vd NA 0.2011 L/kg 1compartment NA NA Rat Human DTXSID8022377 Days.Css NA 9 Days PBTK NA NA Rat Human DTXSID8022377 TK.Half.Life NA 49.51 hours 1compartment NA NA Rat Human -DTXSID8022377 Css NA 0.4245 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022377 Css NA 5.146 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022377 Css NA 0.2566 mg/L PBTK NA 50% Rat Human -DTXSID8022377 Css NA 2.901 mg/L PBTK NA 95% Rat Human -DTXSID8022404 Clint NA 86.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022404 Fup NA 0.0656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022404 Vd NA 1.253 L/kg 1compartment NA NA Human Human -DTXSID8022404 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022404 TK.Half.Life NA 1.994 hours 1compartment NA NA Human Human -DTXSID8022404 Css NA 0.1152 mg/L 3compartmentss NA 50% Human Human -DTXSID8022404 Css NA 0.868 mg/L 3compartmentss NA 95% Human Human -DTXSID8022404 Css NA 0.07405 mg/L PBTK NA 50% Human Human -DTXSID8022404 Css NA 0.5331 mg/L PBTK NA 95% Human Human -DTXSID8022404 Clint NA 86.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022404 Fup NA 0.0656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022404 Vd NA 0.9508 L/kg 1compartment NA NA Rat Human +DTXSID8022377 Css NA 0.0955 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022377 Css NA 1.181 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022377 Css NA 0.05949 mg/L PBTK NA 50% Rat Human +DTXSID8022377 Css NA 0.6921 mg/L PBTK NA 95% Rat Human +DTXSID8022404 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022404 Fup 0.0174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022404 Vd NA 1.418 L/kg 1compartment NA NA Human Human +DTXSID8022404 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8022404 TK.Half.Life NA 14.32 hours 1compartment NA NA Human Human +DTXSID8022404 Css NA 1.59 mg/L 3compartmentss NA 50% Human Human +DTXSID8022404 Css NA 14.59 mg/L 3compartmentss NA 95% Human Human +DTXSID8022404 Css NA 0.9843 mg/L PBTK NA 50% Human Human +DTXSID8022404 Css NA 8.82 mg/L PBTK NA 95% Human Human +DTXSID8022404 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022404 Fup 0.0174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022404 Vd NA 1.049 L/kg 1compartment NA NA Rat Human DTXSID8022404 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022404 TK.Half.Life NA 0.7599 hours 1compartment NA NA Rat Human -DTXSID8022404 Css NA 0.06554 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022404 Css NA 0.3799 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022404 Css NA 0.03962 mg/L PBTK NA 50% Rat Human -DTXSID8022404 Css NA 0.222 mg/L PBTK NA 95% Rat Human +DTXSID8022404 TK.Half.Life NA 5.635 hours 1compartment NA NA Rat Human +DTXSID8022404 Css NA 0.2082 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022404 Css NA 1.572 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022404 Css NA 0.1256 mg/L PBTK NA 50% Rat Human +DTXSID8022404 Css NA 0.9134 mg/L PBTK NA 95% Rat Human DTXSID8022406 Clint 39.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8022406 Fup 0.0113 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8022406 Vd NA 0.4107 L/kg 1compartment NA NA Human Human +DTXSID8022406 Vd NA 0.4295 L/kg 1compartment NA NA Human Human DTXSID8022406 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022406 TK.Half.Life NA 3.599 hours 1compartment NA NA Human Human -DTXSID8022406 Css NA 0.9887 mg/L 3compartmentss NA 50% Human Human -DTXSID8022406 Css NA 7.211 mg/L 3compartmentss NA 95% Human Human -DTXSID8022406 Css NA 0.5841 mg/L PBTK NA 50% Human Human -DTXSID8022406 Css NA 4.204 mg/L PBTK NA 95% Human Human +DTXSID8022406 TK.Half.Life NA 3.745 hours 1compartment NA NA Human Human +DTXSID8022406 Css NA 0.9396 mg/L 3compartmentss NA 50% Human Human +DTXSID8022406 Css NA 6.887 mg/L 3compartmentss NA 95% Human Human +DTXSID8022406 Css NA 0.5587 mg/L PBTK NA 50% Human Human +DTXSID8022406 Css NA 4.101 mg/L PBTK NA 95% Human Human DTXSID8022406 Clint 45.5 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID8022406 Fup 0.0188 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID8022406 Vd NA 0.4014 L/kg 1compartment NA NA Rat Rat +DTXSID8022406 Vd NA 0.4192 L/kg 1compartment NA NA Rat Rat DTXSID8022406 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8022406 TK.Half.Life NA 1.281 hours 1compartment NA NA Rat Rat -DTXSID8022406 Css NA 0.4465 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8022406 Css NA 3.834 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8022406 Css NA 0.2481 mg/L PBTK NA 50% Rat Rat -DTXSID8022406 Css NA 2.088 mg/L PBTK NA 95% Rat Rat +DTXSID8022406 TK.Half.Life NA 1.331 hours 1compartment NA NA Rat Rat +DTXSID8022406 Css NA 0.1011 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8022406 Css NA 0.8318 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8022406 Css NA 0.05822 mg/L PBTK NA 50% Rat Rat +DTXSID8022406 Css NA 0.4707 mg/L PBTK NA 95% Rat Rat DTXSID8022408 Clint 1.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8022408 Fup 0.142 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8022408 Vd NA 1.998 L/kg 1compartment NA NA Human Human -DTXSID8022408 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID8022408 TK.Half.Life NA 52 hours 1compartment NA NA Human Human -DTXSID8022408 Css NA 2.912 mg/L 3compartmentss NA 50% Human Human -DTXSID8022408 Css NA 11.19 mg/L 3compartmentss NA 95% Human Human -DTXSID8022408 Css NA 2.07 mg/L PBTK NA 50% Human Human -DTXSID8022408 Css NA 7.401 mg/L PBTK NA 95% Human Human +DTXSID8022408 Vd NA 2.881 L/kg 1compartment NA NA Human Human +DTXSID8022408 Days.Css NA 45 Days PBTK NA NA Human Human +DTXSID8022408 TK.Half.Life NA 217.3 hours 1compartment NA NA Human Human +DTXSID8022408 Css NA 7.785 mg/L 3compartmentss NA 50% Human Human +DTXSID8022408 Css NA 31.38 mg/L 3compartmentss NA 95% Human Human +DTXSID8022408 Css NA 5.526 mg/L PBTK NA 50% Human Human +DTXSID8022408 Css NA 21.38 mg/L PBTK NA 95% Human Human DTXSID8022408 Clint 1.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8022408 Fup 0.142 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8022408 Vd NA 1.522 L/kg 1compartment NA NA Rat Human -DTXSID8022408 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8022408 TK.Half.Life NA 13.66 hours 1compartment NA NA Rat Human -DTXSID8022408 Css NA 1.254 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022408 Css NA 3.404 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022408 Css NA 0.8514 mg/L PBTK NA 50% Rat Human -DTXSID8022408 Css NA 2.085 mg/L PBTK NA 95% Rat Human -DTXSID8022585 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022585 Fup NA 0.9536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022585 Vd NA 2.659 L/kg 1compartment NA NA Human Human -DTXSID8022585 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8022585 TK.Half.Life NA 18.05 hours 1compartment NA NA Human Human -DTXSID8022585 Css NA 0.6378 mg/L 3compartmentss NA 50% Human Human -DTXSID8022585 Css NA 2.575 mg/L 3compartmentss NA 95% Human Human -DTXSID8022585 Css NA 0.7158 mg/L PBTK NA 50% Human Human -DTXSID8022585 Css NA 2.156 mg/L PBTK NA 95% Human Human -DTXSID8022585 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022585 Fup NA 0.9536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022585 Vd NA 2.707 L/kg 1compartment NA NA Rat Human +DTXSID8022408 Vd NA 2.17 L/kg 1compartment NA NA Rat Human +DTXSID8022408 Days.Css NA 19 Days PBTK NA NA Rat Human +DTXSID8022408 TK.Half.Life NA 32.02 hours 1compartment NA NA Rat Human +DTXSID8022408 Css NA 0.3453 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022408 Css NA 1.528 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022408 Css NA 0.2394 mg/L PBTK NA 50% Rat Human +DTXSID8022408 Css NA 1.025 mg/L PBTK NA 95% Rat Human +DTXSID8022585 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022585 Fup 0.75 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022585 Vd NA 0.6004 L/kg 1compartment NA NA Human Human +DTXSID8022585 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8022585 TK.Half.Life NA 5.18 hours 1compartment NA NA Human Human +DTXSID8022585 Css NA 0.5868 mg/L 3compartmentss NA 50% Human Human +DTXSID8022585 Css NA 3.573 mg/L 3compartmentss NA 95% Human Human +DTXSID8022585 Css NA 0.4658 mg/L PBTK NA 50% Human Human +DTXSID8022585 Css NA 2.288 mg/L PBTK NA 95% Human Human +DTXSID8022585 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022585 Fup 0.75 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022585 Vd NA 0.6403 L/kg 1compartment NA NA Rat Human DTXSID8022585 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022585 TK.Half.Life NA 6.261 hours 1compartment NA NA Rat Human -DTXSID8022585 Css NA 0.1592 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022585 Css NA 0.5843 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022585 Css NA 0.1793 mg/L PBTK NA 50% Rat Human -DTXSID8022585 Css NA 0.4516 mg/L PBTK NA 95% Rat Human +DTXSID8022585 TK.Half.Life NA 1.882 hours 1compartment NA NA Rat Human +DTXSID8022585 Css NA 0.002989 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022585 Css NA 0.02072 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022585 Css NA 0.002298 mg/L PBTK NA 50% Rat Human +DTXSID8022585 Css NA 0.0126 mg/L PBTK NA 95% Rat Human DTXSID8022589 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human DTXSID8022589 Fup 0.563 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Human Human -DTXSID8022589 Vd NA 0.5413 L/kg 1compartment NA NA Human Human +DTXSID8022589 Vd NA 1.163 L/kg 1compartment NA NA Human Human DTXSID8022589 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022589 TK.Half.Life NA 2.936 hours 1compartment NA NA Human Human -DTXSID8022589 Css NA 0.6143 mg/L 3compartmentss NA 50% Human Human -DTXSID8022589 Css NA 4.198 mg/L 3compartmentss NA 95% Human Human -DTXSID8022589 Css NA 0.4662 mg/L PBTK NA 50% Human Human -DTXSID8022589 Css NA 2.612 mg/L PBTK NA 95% Human Human +DTXSID8022589 TK.Half.Life NA 6.684 hours 1compartment NA NA Human Human +DTXSID8022589 Css NA 0.5652 mg/L 3compartmentss NA 50% Human Human +DTXSID8022589 Css NA 3.969 mg/L 3compartmentss NA 95% Human Human +DTXSID8022589 Css NA 0.4778 mg/L PBTK NA 50% Human Human +DTXSID8022589 Css NA 2.593 mg/L PBTK NA 95% Human Human DTXSID8022589 Clint 0.723 NA uL/min/million hepatocytes NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human DTXSID8022589 Fup 0.563 NA NA https://doi.org/10.1007/s00204-011-0768-0 NA Rat Human -DTXSID8022589 Vd NA 0.5693 L/kg 1compartment NA NA Rat Human +DTXSID8022589 Vd NA 1.051 L/kg 1compartment NA NA Rat Human DTXSID8022589 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022589 TK.Half.Life NA 1.431 hours 1compartment NA NA Rat Human -DTXSID8022589 Css NA 0.2287 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022589 Css NA 1.432 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022589 Css NA 0.1662 mg/L PBTK NA 50% Rat Human -DTXSID8022589 Css NA 0.8311 mg/L PBTK NA 95% Rat Human -DTXSID8022610 Clint NA 58.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022610 Fup NA 0.098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022610 Vd NA 1.457 L/kg 1compartment NA NA Human Human +DTXSID8022589 TK.Half.Life NA 2.667 hours 1compartment NA NA Rat Human +DTXSID8022589 Css NA 0.04866 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022589 Css NA 0.3084 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022589 Css NA 0.04124 mg/L PBTK NA 50% Rat Human +DTXSID8022589 Css NA 0.1928 mg/L PBTK NA 95% Rat Human +DTXSID8022610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022610 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022610 Vd NA 2.659 L/kg 1compartment NA NA Human Human DTXSID8022610 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022610 TK.Half.Life NA 1.82 hours 1compartment NA NA Human Human -DTXSID8022610 Css NA 0.07722 mg/L 3compartmentss NA 50% Human Human -DTXSID8022610 Css NA 0.7119 mg/L 3compartmentss NA 95% Human Human -DTXSID8022610 Css NA 0.05845 mg/L PBTK NA 50% Human Human -DTXSID8022610 Css NA 0.4816 mg/L PBTK NA 95% Human Human -DTXSID8022610 Clint NA 58.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022610 Fup NA 0.098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022610 Vd NA 1.436 L/kg 1compartment NA NA Rat Human +DTXSID8022610 TK.Half.Life NA 3.515 hours 1compartment NA NA Human Human +DTXSID8022610 Css NA 0.08075 mg/L 3compartmentss NA 50% Human Human +DTXSID8022610 Css NA 0.8591 mg/L 3compartmentss NA 95% Human Human +DTXSID8022610 Css NA 0.07861 mg/L PBTK NA 50% Human Human +DTXSID8022610 Css NA 0.6578 mg/L PBTK NA 95% Human Human +DTXSID8022610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022610 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022610 Vd NA 2.646 L/kg 1compartment NA NA Rat Human DTXSID8022610 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022610 TK.Half.Life NA 0.9807 hours 1compartment NA NA Rat Human -DTXSID8022610 Css NA 0.04326 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022610 Css NA 0.3372 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022610 Css NA 0.03122 mg/L PBTK NA 50% Rat Human -DTXSID8022610 Css NA 0.2112 mg/L PBTK NA 95% Rat Human -DTXSID8022612 Clint NA 0.9277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022612 Fup NA 0.7976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022612 Vd NA 10.48 L/kg 1compartment NA NA Human Human -DTXSID8022612 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8022612 TK.Half.Life NA 28.69 hours 1compartment NA NA Human Human -DTXSID8022612 Css NA 0.08843 mg/L 3compartmentss NA 50% Human Human -DTXSID8022612 Css NA 0.9255 mg/L 3compartmentss NA 95% Human Human -DTXSID8022612 Css NA 0.2519 mg/L PBTK NA 50% Human Human -DTXSID8022612 Css NA 1.274 mg/L PBTK NA 95% Human Human -DTXSID8022612 Clint NA 0.9277 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022612 Fup NA 0.7976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022612 Vd NA 10.67 L/kg 1compartment NA NA Rat Human -DTXSID8022612 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8022612 TK.Half.Life NA 12.4 hours 1compartment NA NA Rat Human -DTXSID8022612 Css NA 0.03517 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022612 Css NA 0.3738 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022612 Css NA 0.1071 mg/L PBTK NA 50% Rat Human -DTXSID8022612 Css NA 0.4508 mg/L PBTK NA 95% Rat Human -DTXSID8022614 Clint NA 2.528 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8022610 TK.Half.Life NA 2.024 hours 1compartment NA NA Rat Human +DTXSID8022610 Css NA 0.01041 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022610 Css NA 0.08563 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022610 Css NA 0.01006 mg/L PBTK NA 50% Rat Human +DTXSID8022610 Css NA 0.06593 mg/L PBTK NA 95% Rat Human +DTXSID8022614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8022614 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8022614 Vd NA 0.7593 L/kg 1compartment NA NA Human Human -DTXSID8022614 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8022614 TK.Half.Life NA 19.07 hours 1compartment NA NA Human Human -DTXSID8022614 Css NA 4.212 mg/L 3compartmentss NA 50% Human Human -DTXSID8022614 Css NA 26.18 mg/L 3compartmentss NA 95% Human Human -DTXSID8022614 Css NA 2.624 mg/L PBTK NA 50% Human Human -DTXSID8022614 Css NA 15.36 mg/L PBTK NA 95% Human Human -DTXSID8022614 Clint NA 2.528 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8022614 Vd NA 1.151 L/kg 1compartment NA NA Human Human +DTXSID8022614 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8022614 TK.Half.Life NA 4.507 hours 1compartment NA NA Human Human +DTXSID8022614 Css NA 0.5058 mg/L 3compartmentss NA 50% Human Human +DTXSID8022614 Css NA 4.474 mg/L 3compartmentss NA 95% Human Human +DTXSID8022614 Css NA 0.3339 mg/L PBTK NA 50% Human Human +DTXSID8022614 Css NA 2.796 mg/L PBTK NA 95% Human Human +DTXSID8022614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8022614 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8022614 Vd NA 0.6331 L/kg 1compartment NA NA Rat Human +DTXSID8022614 Vd NA 1.051 L/kg 1compartment NA NA Rat Human DTXSID8022614 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022614 TK.Half.Life NA 8.887 hours 1compartment NA NA Rat Human -DTXSID8022614 Css NA 2.045 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022614 Css NA 9.952 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022614 Css NA 1.195 mg/L PBTK NA 50% Rat Human -DTXSID8022614 Css NA 5.491 mg/L PBTK NA 95% Rat Human -DTXSID8022741 Clint NA 29.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022741 Fup NA 0.1517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022741 Vd NA 0.28 L/kg 1compartment NA NA Human Human +DTXSID8022614 TK.Half.Life NA 2.502 hours 1compartment NA NA Rat Human +DTXSID8022614 Css NA 0.0662 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022614 Css NA 0.4533 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022614 Css NA 0.04246 mg/L PBTK NA 50% Rat Human +DTXSID8022614 Css NA 0.2701 mg/L PBTK NA 95% Rat Human +DTXSID8022741 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022741 Fup 0.483 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022741 Vd NA 0.4694 L/kg 1compartment NA NA Human Human DTXSID8022741 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022741 TK.Half.Life NA 0.48 hours 1compartment NA NA Human Human -DTXSID8022741 Css NA 0.1359 mg/L 3compartmentss NA 50% Human Human -DTXSID8022741 Css NA 1.079 mg/L 3compartmentss NA 95% Human Human -DTXSID8022741 Css NA 0.08509 mg/L PBTK NA 50% Human Human -DTXSID8022741 Css NA 0.6396 mg/L PBTK NA 95% Human Human -DTXSID8022741 Clint NA 29.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022741 Fup NA 0.1517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022741 Vd NA 0.2774 L/kg 1compartment NA NA Rat Human +DTXSID8022741 TK.Half.Life NA 6.301 hours 1compartment NA NA Human Human +DTXSID8022741 Css NA 1.529 mg/L 3compartmentss NA 50% Human Human +DTXSID8022741 Css NA 7.319 mg/L 3compartmentss NA 95% Human Human +DTXSID8022741 Css NA 1.112 mg/L PBTK NA 50% Human Human +DTXSID8022741 Css NA 4.542 mg/L PBTK NA 95% Human Human +DTXSID8022741 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022741 Fup 0.483 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022741 Vd NA 0.4692 L/kg 1compartment NA NA Rat Human DTXSID8022741 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022741 TK.Half.Life NA 0.2627 hours 1compartment NA NA Rat Human -DTXSID8022741 Css NA 0.07616 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022741 Css NA 0.4791 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022741 Css NA 0.04456 mg/L PBTK NA 50% Rat Human -DTXSID8022741 Css NA 0.2685 mg/L PBTK NA 95% Rat Human -DTXSID8022743 Clint NA 19.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8022741 TK.Half.Life NA 2.143 hours 1compartment NA NA Rat Human +DTXSID8022741 Css NA 0.09623 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022741 Css NA 0.414 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022741 Css NA 0.0689 mg/L PBTK NA 50% Rat Human +DTXSID8022741 Css NA 0.2495 mg/L PBTK NA 95% Rat Human +DTXSID8022743 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8022743 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8022743 Vd NA 0.3687 L/kg 1compartment NA NA Human Human -DTXSID8022743 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022743 TK.Half.Life NA 0.6001 hours 1compartment NA NA Human Human -DTXSID8022743 Css NA 0.1108 mg/L 3compartmentss NA 50% Human Human -DTXSID8022743 Css NA 0.7585 mg/L 3compartmentss NA 95% Human Human -DTXSID8022743 Css NA 0.07281 mg/L PBTK NA 50% Human Human -DTXSID8022743 Css NA 0.4808 mg/L PBTK NA 95% Human Human -DTXSID8022743 Clint NA 19.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8022743 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8022743 TK.Half.Life NA 10.4 hours 1compartment NA NA Human Human +DTXSID8022743 Css NA 3.374 mg/L 3compartmentss NA 50% Human Human +DTXSID8022743 Css NA 12.51 mg/L 3compartmentss NA 95% Human Human +DTXSID8022743 Css NA 2.237 mg/L PBTK NA 50% Human Human +DTXSID8022743 Css NA 7.593 mg/L PBTK NA 95% Human Human +DTXSID8022743 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8022743 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8022743 Vd NA 0.3603 L/kg 1compartment NA NA Rat Human DTXSID8022743 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022743 TK.Half.Life NA 0.3213 hours 1compartment NA NA Rat Human -DTXSID8022743 Css NA 0.06086 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022743 Css NA 0.305 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022743 Css NA 0.03809 mg/L PBTK NA 50% Rat Human -DTXSID8022743 Css NA 0.1829 mg/L PBTK NA 95% Rat Human +DTXSID8022743 TK.Half.Life NA 3.455 hours 1compartment NA NA Rat Human +DTXSID8022743 Css NA 0.2187 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022743 Css NA 0.6706 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022743 Css NA 0.1415 mg/L PBTK NA 50% Rat Human +DTXSID8022743 Css NA 0.396 mg/L PBTK NA 95% Rat Human DTXSID8022747 Clint 98.52 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8022747 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8022747 Vd NA 2.396 L/kg 1compartment NA NA Human Human DTXSID8022747 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8022747 TK.Half.Life NA 7.549 hours 1compartment NA NA Human Human -DTXSID8022747 Css NA 0.2428 mg/L 3compartmentss NA 50% Human Human -DTXSID8022747 Css NA 1.871 mg/L 3compartmentss NA 95% Human Human -DTXSID8022747 Css NA 0.1523 mg/L PBTK NA 50% Human Human -DTXSID8022747 Css NA 1.142 mg/L PBTK NA 95% Human Human +DTXSID8022747 Css NA 0.3308 mg/L 3compartmentss NA 50% Human Human +DTXSID8022747 Css NA 2.588 mg/L 3compartmentss NA 95% Human Human +DTXSID8022747 Css NA 0.2382 mg/L PBTK NA 50% Human Human +DTXSID8022747 Css NA 1.862 mg/L PBTK NA 95% Human Human DTXSID8022747 Clint 98.52 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID8022747 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8022747 Vd NA 1.802 L/kg 1compartment NA NA Rat Human DTXSID8022747 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8022747 TK.Half.Life NA 2.157 hours 1compartment NA NA Rat Human -DTXSID8022747 Css NA 0.2208 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022747 Css NA 1.439 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022747 Css NA 0.1311 mg/L PBTK NA 50% Rat Human -DTXSID8022747 Css NA 0.8377 mg/L PBTK NA 95% Rat Human -DTXSID8022749 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8022747 Css NA 0.04057 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022747 Css NA 0.2754 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022747 Css NA 0.03024 mg/L PBTK NA 50% Rat Human +DTXSID8022747 Css NA 0.2054 mg/L PBTK NA 95% Rat Human +DTXSID8022749 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8022749 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8022749 Vd NA 1.511 L/kg 1compartment NA NA Human Human -DTXSID8022749 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8022749 TK.Half.Life NA 25.21 hours 1compartment NA NA Human Human -DTXSID8022749 Css NA 1.606 mg/L 3compartmentss NA 50% Human Human -DTXSID8022749 Css NA 7.436 mg/L 3compartmentss NA 95% Human Human -DTXSID8022749 Css NA 1.379 mg/L PBTK NA 50% Human Human -DTXSID8022749 Css NA 5.129 mg/L PBTK NA 95% Human Human -DTXSID8022749 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8022749 Vd NA 0.7296 L/kg 1compartment NA NA Human Human +DTXSID8022749 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8022749 TK.Half.Life NA 12.11 hours 1compartment NA NA Human Human +DTXSID8022749 Css NA 0.9674 mg/L 3compartmentss NA 50% Human Human +DTXSID8022749 Css NA 4.624 mg/L 3compartmentss NA 95% Human Human +DTXSID8022749 Css NA 0.7301 mg/L PBTK NA 50% Human Human +DTXSID8022749 Css NA 3.012 mg/L PBTK NA 95% Human Human +DTXSID8022749 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8022749 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8022749 Vd NA 1.516 L/kg 1compartment NA NA Rat Human +DTXSID8022749 Vd NA 0.7529 L/kg 1compartment NA NA Rat Human DTXSID8022749 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022749 TK.Half.Life NA 8.579 hours 1compartment NA NA Rat Human -DTXSID8022749 Css NA 0.4328 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022749 Css NA 1.749 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022749 Css NA 0.3613 mg/L PBTK NA 50% Rat Human -DTXSID8022749 Css NA 1.112 mg/L PBTK NA 95% Rat Human -DTXSID8022822 Clint NA 0.1319 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022822 Fup NA 0.1011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022822 Vd NA 0.3261 L/kg 1compartment NA NA Human Human -DTXSID8022822 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8022822 TK.Half.Life NA 17.11 hours 1compartment NA NA Human Human -DTXSID8022822 Css NA 8.061 mg/L 3compartmentss NA 50% Human Human -DTXSID8022822 Css NA 37.07 mg/L 3compartmentss NA 95% Human Human -DTXSID8022822 Css NA 5.008 mg/L PBTK NA 50% Human Human -DTXSID8022822 Css NA 22.02 mg/L PBTK NA 95% Human Human -DTXSID8022822 Clint NA 0.1319 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022822 Fup NA 0.1011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022822 Vd NA 0.3252 L/kg 1compartment NA NA Rat Human +DTXSID8022749 TK.Half.Life NA 4.258 hours 1compartment NA NA Rat Human +DTXSID8022749 Css NA 0.005206 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022749 Css NA 0.02474 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022749 Css NA 0.00378 mg/L PBTK NA 50% Rat Human +DTXSID8022749 Css NA 0.01538 mg/L PBTK NA 95% Rat Human +DTXSID8022822 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022822 Fup 0.302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022822 Vd NA 0.5783 L/kg 1compartment NA NA Human Human +DTXSID8022822 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8022822 TK.Half.Life NA 12.39 hours 1compartment NA NA Human Human +DTXSID8022822 Css NA 2.3 mg/L 3compartmentss NA 50% Human Human +DTXSID8022822 Css NA 9.389 mg/L 3compartmentss NA 95% Human Human +DTXSID8022822 Css NA 1.695 mg/L PBTK NA 50% Human Human +DTXSID8022822 Css NA 6.045 mg/L PBTK NA 95% Human Human +DTXSID8022822 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022822 Fup 0.302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022822 Vd NA 0.5811 L/kg 1compartment NA NA Rat Human DTXSID8022822 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022822 TK.Half.Life NA 6.406 hours 1compartment NA NA Rat Human -DTXSID8022822 Css NA 2.513 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022822 Css NA 10.42 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022822 Css NA 1.473 mg/L PBTK NA 50% Rat Human -DTXSID8022822 Css NA 5.748 mg/L PBTK NA 95% Rat Human +DTXSID8022822 TK.Half.Life NA 4.242 hours 1compartment NA NA Rat Human +DTXSID8022822 Css NA 0.148 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022822 Css NA 0.5113 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022822 Css NA 0.1082 mg/L PBTK NA 50% Rat Human +DTXSID8022822 Css NA 0.3164 mg/L PBTK NA 95% Rat Human DTXSID8022824 Clint 4.17 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8022824 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8022824 Vd NA 0.7471 L/kg 1compartment NA NA Human Human DTXSID8022824 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8022824 TK.Half.Life NA 1.162 hours 1compartment NA NA Human Human -DTXSID8022824 Css NA 0.08636 mg/L 3compartmentss NA 50% Human Human -DTXSID8022824 Css NA 0.8137 mg/L 3compartmentss NA 95% Human Human -DTXSID8022824 Css NA 0.08682 mg/L PBTK NA 50% Human Human -DTXSID8022824 Css NA 0.5959 mg/L PBTK NA 95% Human Human +DTXSID8022824 Css NA 0.05152 mg/L 3compartmentss NA 50% Human Human +DTXSID8022824 Css NA 0.3985 mg/L 3compartmentss NA 95% Human Human +DTXSID8022824 Css NA 0.05476 mg/L PBTK NA 50% Human Human +DTXSID8022824 Css NA 0.4257 mg/L PBTK NA 95% Human Human DTXSID8022824 Clint 4.17 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8022824 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8022824 Vd NA 0.7786 L/kg 1compartment NA NA Rat Human DTXSID8022824 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8022824 TK.Half.Life NA 0.6743 hours 1compartment NA NA Rat Human -DTXSID8022824 Css NA 0.05262 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022824 Css NA 0.4299 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022824 Css NA 0.05171 mg/L PBTK NA 50% Rat Human -DTXSID8022824 Css NA 0.2835 mg/L PBTK NA 95% Rat Human +DTXSID8022824 Css NA 0.0003928 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022824 Css NA 0.002823 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022824 Css NA 0.0004215 mg/L PBTK NA 50% Rat Human +DTXSID8022824 Css NA 0.003031 mg/L PBTK NA 95% Rat Human +DTXSID8022826 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID8022826 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8022826 Vd NA 1.986 L/kg 1compartment NA NA Human Human +DTXSID8022826 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8022826 TK.Half.Life NA 17.48 hours 1compartment NA NA Human Human +DTXSID8022826 Css NA 0.8589 mg/L 3compartmentss NA 50% Human Human +DTXSID8022826 Css NA 4.167 mg/L 3compartmentss NA 95% Human Human +DTXSID8022826 Css NA 0.6988 mg/L PBTK NA 50% Human Human +DTXSID8022826 Css NA 2.944 mg/L PBTK NA 95% Human Human +DTXSID8022826 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID8022826 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8022826 Vd NA 1.805 L/kg 1compartment NA NA Rat Human +DTXSID8022826 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8022826 TK.Half.Life NA 7.795 hours 1compartment NA NA Rat Human +DTXSID8022826 Css NA 0.08865 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022826 Css NA 0.3363 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022826 Css NA 0.0723 mg/L PBTK NA 50% Rat Human +DTXSID8022826 Css NA 0.2228 mg/L PBTK NA 95% Rat Human DTXSID8022828 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8022828 Fup 0.9848 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8022828 Vd NA 0.9452 L/kg 1compartment NA NA Human Human DTXSID8022828 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8022828 TK.Half.Life NA 6.256 hours 1compartment NA NA Human Human -DTXSID8022828 Css NA 0.8039 mg/L 3compartmentss NA 50% Human Human -DTXSID8022828 Css NA 2.692 mg/L 3compartmentss NA 95% Human Human -DTXSID8022828 Css NA 0.705 mg/L PBTK NA 50% Human Human -DTXSID8022828 Css NA 1.959 mg/L PBTK NA 95% Human Human +DTXSID8022828 Css NA 0.766 mg/L 3compartmentss NA 50% Human Human +DTXSID8022828 Css NA 2.604 mg/L 3compartmentss NA 95% Human Human +DTXSID8022828 Css NA 0.6688 mg/L PBTK NA 50% Human Human +DTXSID8022828 Css NA 1.9 mg/L PBTK NA 95% Human Human DTXSID8022828 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID8022828 Fup 0.9848 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID8022828 Vd NA 0.9567 L/kg 1compartment NA NA Rat Human DTXSID8022828 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8022828 TK.Half.Life NA 2.146 hours 1compartment NA NA Rat Human -DTXSID8022828 Css NA 0.2034 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022828 Css NA 0.6289 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022828 Css NA 0.1754 mg/L PBTK NA 50% Rat Human -DTXSID8022828 Css NA 0.4236 mg/L PBTK NA 95% Rat Human +DTXSID8022828 Css NA 0.0401 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022828 Css NA 0.1198 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022828 Css NA 0.03642 mg/L PBTK NA 50% Rat Human +DTXSID8022828 Css NA 0.08448 mg/L PBTK NA 95% Rat Human DTXSID8022870 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8022870 Fup NA 0.9606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022870 Vd NA 0.5351 L/kg 1compartment NA NA Human Human +DTXSID8022870 Vd NA 0.5305 L/kg 1compartment NA NA Human Human DTXSID8022870 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022870 TK.Half.Life NA 3.605 hours 1compartment NA NA Human Human -DTXSID8022870 Css NA 0.9895 mg/L 3compartmentss NA 50% Human Human -DTXSID8022870 Css NA 5.154 mg/L 3compartmentss NA 95% Human Human -DTXSID8022870 Css NA 0.7449 mg/L PBTK NA 50% Human Human -DTXSID8022870 Css NA 3.3 mg/L PBTK NA 95% Human Human +DTXSID8022870 TK.Half.Life NA 3.573 hours 1compartment NA NA Human Human +DTXSID8022870 Css NA 0.8353 mg/L 3compartmentss NA 50% Human Human +DTXSID8022870 Css NA 4.337 mg/L 3compartmentss NA 95% Human Human +DTXSID8022870 Css NA 0.6292 mg/L PBTK NA 50% Human Human +DTXSID8022870 Css NA 2.768 mg/L PBTK NA 95% Human Human DTXSID8022870 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8022870 Fup NA 0.9606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022870 Vd NA 0.5612 L/kg 1compartment NA NA Rat Human +DTXSID8022870 Vd NA 0.556 L/kg 1compartment NA NA Rat Human DTXSID8022870 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022870 TK.Half.Life NA 1.288 hours 1compartment NA NA Rat Human -DTXSID8022870 Css NA 0.2531 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022870 Css NA 1.264 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022870 Css NA 0.1842 mg/L PBTK NA 50% Rat Human -DTXSID8022870 Css NA 0.7418 mg/L PBTK NA 95% Rat Human -DTXSID8022872 Clint NA 4.101 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022872 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022872 Vd NA 3.13 L/kg 1compartment NA NA Human Human -DTXSID8022872 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8022872 TK.Half.Life NA 15.18 hours 1compartment NA NA Human Human -DTXSID8022872 Css NA 0.5098 mg/L 3compartmentss NA 50% Human Human -DTXSID8022872 Css NA 4.183 mg/L 3compartmentss NA 95% Human Human -DTXSID8022872 Css NA 0.4551 mg/L PBTK NA 50% Human Human -DTXSID8022872 Css NA 3.178 mg/L PBTK NA 95% Human Human -DTXSID8022872 Clint NA 4.101 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022872 Fup NA 0.0641 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022872 Vd NA 2.935 L/kg 1compartment NA NA Rat Human +DTXSID8022870 TK.Half.Life NA 1.276 hours 1compartment NA NA Rat Human +DTXSID8022870 Css NA 0.01553 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022870 Css NA 0.1063 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022870 Css NA 0.01109 mg/L PBTK NA 50% Rat Human +DTXSID8022870 Css NA 0.06668 mg/L PBTK NA 95% Rat Human +DTXSID8022872 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022872 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022872 Vd NA 5.618 L/kg 1compartment NA NA Human Human +DTXSID8022872 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8022872 TK.Half.Life NA 9.143 hours 1compartment NA NA Human Human +DTXSID8022872 Css NA 0.07884 mg/L 3compartmentss NA 50% Human Human +DTXSID8022872 Css NA 0.5822 mg/L 3compartmentss NA 95% Human Human +DTXSID8022872 Css NA 0.1074 mg/L PBTK NA 50% Human Human +DTXSID8022872 Css NA 0.6589 mg/L PBTK NA 95% Human Human +DTXSID8022872 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022872 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022872 Vd NA 5.366 L/kg 1compartment NA NA Rat Human DTXSID8022872 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022872 TK.Half.Life NA 7.574 hours 1compartment NA NA Rat Human -DTXSID8022872 Css NA 0.2764 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022872 Css NA 1.663 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022872 Css NA 0.2383 mg/L PBTK NA 50% Rat Human -DTXSID8022872 Css NA 1.212 mg/L PBTK NA 95% Rat Human -DTXSID8022901 Clint NA 5.463 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022901 Fup NA 0.1299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022901 Vd NA 1.635 L/kg 1compartment NA NA Human Human +DTXSID8022872 TK.Half.Life NA 3.428 hours 1compartment NA NA Rat Human +DTXSID8022872 Css NA 0.009354 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022872 Css NA 0.05385 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022872 Css NA 0.01357 mg/L PBTK NA 50% Rat Human +DTXSID8022872 Css NA 0.06405 mg/L PBTK NA 95% Rat Human +DTXSID8022901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022901 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022901 Vd NA 1.986 L/kg 1compartment NA NA Human Human DTXSID8022901 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022901 TK.Half.Life NA 11.34 hours 1compartment NA NA Human Human -DTXSID8022901 Css NA 0.9113 mg/L 3compartmentss NA 50% Human Human -DTXSID8022901 Css NA 5.788 mg/L 3compartmentss NA 95% Human Human -DTXSID8022901 Css NA 0.6158 mg/L PBTK NA 50% Human Human -DTXSID8022901 Css NA 3.678 mg/L PBTK NA 95% Human Human -DTXSID8022901 Clint NA 5.463 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022901 Fup NA 0.1299 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022901 Vd NA 1.252 L/kg 1compartment NA NA Rat Human +DTXSID8022901 TK.Half.Life NA 3.866 hours 1compartment NA NA Human Human +DTXSID8022901 Css NA 0.1429 mg/L 3compartmentss NA 50% Human Human +DTXSID8022901 Css NA 0.95 mg/L 3compartmentss NA 95% Human Human +DTXSID8022901 Css NA 0.1037 mg/L PBTK NA 50% Human Human +DTXSID8022901 Css NA 0.6398 mg/L PBTK NA 95% Human Human +DTXSID8022901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022901 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022901 Vd NA 1.531 L/kg 1compartment NA NA Rat Human DTXSID8022901 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022901 TK.Half.Life NA 4.128 hours 1compartment NA NA Rat Human -DTXSID8022901 Css NA 0.4754 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022901 Css NA 2.113 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022901 Css NA 0.3049 mg/L PBTK NA 50% Rat Human -DTXSID8022901 Css NA 1.248 mg/L PBTK NA 95% Rat Human -DTXSID8022955 Clint NA 35.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022955 Fup NA 0.1976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022955 Vd NA 3.136 L/kg 1compartment NA NA Human Human -DTXSID8022955 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID8022955 TK.Half.Life NA 50.52 hours 1compartment NA NA Human Human -DTXSID8022955 Css NA 1.9 mg/L 3compartmentss NA 50% Human Human -DTXSID8022955 Css NA 12.01 mg/L 3compartmentss NA 95% Human Human -DTXSID8022955 Css NA 1.326 mg/L PBTK NA 50% Human Human -DTXSID8022955 Css NA 8.052 mg/L PBTK NA 95% Human Human -DTXSID8022955 Clint NA 35.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022955 Fup NA 0.1976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022955 Vd NA 2.35 L/kg 1compartment NA NA Rat Human -DTXSID8022955 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID8022955 TK.Half.Life NA 6.89 hours 1compartment NA NA Rat Human -DTXSID8022955 Css NA 1.051 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022955 Css NA 5.524 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022955 Css NA 0.7036 mg/L PBTK NA 50% Rat Human -DTXSID8022955 Css NA 3.561 mg/L PBTK NA 95% Rat Human +DTXSID8022901 TK.Half.Life NA 1.319 hours 1compartment NA NA Rat Human +DTXSID8022901 Css NA 0.01781 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022901 Css NA 0.09159 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022901 Css NA 0.01287 mg/L PBTK NA 50% Rat Human +DTXSID8022901 Css NA 0.06324 mg/L PBTK NA 95% Rat Human +DTXSID8022907 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022907 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8022907 Vd NA 3.867 L/kg 1compartment NA NA Human Human +DTXSID8022907 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8022907 TK.Half.Life NA 2.056 hours 1compartment NA NA Human Human +DTXSID8022907 Css NA 0.01536 mg/L 3compartmentss NA 50% Human Human +DTXSID8022907 Css NA 0.2031 mg/L 3compartmentss NA 95% Human Human +DTXSID8022907 Css NA 0.0207 mg/L PBTK NA 50% Human Human +DTXSID8022907 Css NA 0.1902 mg/L PBTK NA 95% Human Human +DTXSID8022907 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022907 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8022907 Vd NA 3.899 L/kg 1compartment NA NA Rat Human +DTXSID8022907 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8022907 TK.Half.Life NA 1.074 hours 1compartment NA NA Rat Human +DTXSID8022907 Css NA 0.001761 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022907 Css NA 0.01982 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022907 Css NA 0.002556 mg/L PBTK NA 50% Rat Human +DTXSID8022907 Css NA 0.01788 mg/L PBTK NA 95% Rat Human +DTXSID8022955 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022955 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022955 Vd NA 1.739 L/kg 1compartment NA NA Human Human +DTXSID8022955 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8022955 TK.Half.Life NA 11.82 hours 1compartment NA NA Human Human +DTXSID8022955 Css NA 0.863 mg/L 3compartmentss NA 50% Human Human +DTXSID8022955 Css NA 5.392 mg/L 3compartmentss NA 95% Human Human +DTXSID8022955 Css NA 0.587 mg/L PBTK NA 50% Human Human +DTXSID8022955 Css NA 3.419 mg/L PBTK NA 95% Human Human +DTXSID8022955 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022955 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022955 Vd NA 1.33 L/kg 1compartment NA NA Rat Human +DTXSID8022955 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8022955 TK.Half.Life NA 4.201 hours 1compartment NA NA Rat Human +DTXSID8022955 Css NA 0.1058 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022955 Css NA 0.4906 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022955 Css NA 0.07063 mg/L PBTK NA 50% Rat Human +DTXSID8022955 Css NA 0.3041 mg/L PBTK NA 95% Rat Human DTXSID8022959 Clint 49.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8022959 Fup NA 0.0389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8022959 Vd NA 0.503 L/kg 1compartment NA NA Human Human +DTXSID8022959 Fup 0.0918 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8022959 Vd NA 2.476 L/kg 1compartment NA NA Human Human DTXSID8022959 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8022959 TK.Half.Life NA 1.397 hours 1compartment NA NA Human Human -DTXSID8022959 Css NA 0.3485 mg/L 3compartmentss NA 50% Human Human -DTXSID8022959 Css NA 3.267 mg/L 3compartmentss NA 95% Human Human -DTXSID8022959 Css NA 0.2204 mg/L PBTK NA 50% Human Human -DTXSID8022959 Css NA 1.957 mg/L PBTK NA 95% Human Human +DTXSID8022959 TK.Half.Life NA 6.145 hours 1compartment NA NA Human Human +DTXSID8022959 Css NA 0.2285 mg/L 3compartmentss NA 50% Human Human +DTXSID8022959 Css NA 1.513 mg/L 3compartmentss NA 95% Human Human +DTXSID8022959 Css NA 0.1559 mg/L PBTK NA 50% Human Human +DTXSID8022959 Css NA 0.9899 mg/L PBTK NA 95% Human Human DTXSID8022959 Clint 49.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8022959 Fup NA 0.0389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8022959 Vd NA 0.4378 L/kg 1compartment NA NA Rat Human +DTXSID8022959 Fup 0.0918 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8022959 Vd NA 1.865 L/kg 1compartment NA NA Rat Human DTXSID8022959 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8022959 TK.Half.Life NA 0.7337 hours 1compartment NA NA Rat Human -DTXSID8022959 Css NA 0.1976 mg/L 3compartmentss NA 50% Rat Human -DTXSID8022959 Css NA 1.565 mg/L 3compartmentss NA 95% Rat Human -DTXSID8022959 Css NA 0.1172 mg/L PBTK NA 50% Rat Human -DTXSID8022959 Css NA 0.883 mg/L PBTK NA 95% Rat Human -DTXSID8023000 Clint NA 15.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023000 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023000 Vd NA 9.373 L/kg 1compartment NA NA Human Human -DTXSID8023000 Days.Css NA 83 Days PBTK NA NA Human Human -DTXSID8023000 TK.Half.Life NA 381.9 hours 1compartment NA NA Human Human -DTXSID8023000 Css NA 2.913 mg/L 3compartmentss NA 50% Human Human -DTXSID8023000 Css NA 17.58 mg/L 3compartmentss NA 95% Human Human -DTXSID8023000 Css NA 3.308 mg/L PBTK NA 50% Human Human -DTXSID8023000 Css NA 19.41 mg/L PBTK NA 95% Human Human -DTXSID8023000 Clint NA 15.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023000 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023000 Vd NA 7.358 L/kg 1compartment NA NA Rat Human -DTXSID8023000 Days.Css NA 49 Days PBTK NA NA Rat Human -DTXSID8023000 TK.Half.Life NA 52.63 hours 1compartment NA NA Rat Human -DTXSID8023000 Css NA 1.596 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023000 Css NA 6.529 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023000 Css NA 1.812 mg/L PBTK NA 50% Rat Human -DTXSID8023000 Css NA 7.604 mg/L PBTK NA 95% Rat Human -DTXSID8023050 Clint NA 0.9681 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023050 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023050 Vd NA 0.282 L/kg 1compartment NA NA Human Human -DTXSID8023050 Days.Css NA 37 Days PBTK NA NA Human Human -DTXSID8023050 TK.Half.Life NA 162.3 hours 1compartment NA NA Human Human -DTXSID8023050 Css NA 104.8 mg/L 3compartmentss NA 50% Human Human -DTXSID8023050 Css NA 493.9 mg/L 3compartmentss NA 95% Human Human -DTXSID8023050 Css NA 61.94 mg/L PBTK NA 50% Human Human -DTXSID8023050 Css NA 288.9 mg/L PBTK NA 95% Human Human -DTXSID8023050 Clint NA 0.9681 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023050 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023050 Vd NA 0.254 L/kg 1compartment NA NA Rat Human -DTXSID8023050 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID8023050 TK.Half.Life NA 73.88 hours 1compartment NA NA Rat Human -DTXSID8023050 Css NA 44.25 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023050 Css NA 169.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023050 Css NA 24.47 mg/L PBTK NA 50% Rat Human -DTXSID8023050 Css NA 92.25 mg/L PBTK NA 95% Rat Human -DTXSID8023054 Clint NA 218.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8022959 TK.Half.Life NA 1.711 hours 1compartment NA NA Rat Human +DTXSID8022959 Css NA 0.02929 mg/L 3compartmentss NA 50% Rat Human +DTXSID8022959 Css NA 0.1729 mg/L 3compartmentss NA 95% Rat Human +DTXSID8022959 Css NA 0.01982 mg/L PBTK NA 50% Rat Human +DTXSID8022959 Css NA 0.1149 mg/L PBTK NA 95% Rat Human +DTXSID8023000 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023000 Fup 0.012 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023000 Vd NA 3.115 L/kg 1compartment NA NA Human Human +DTXSID8023000 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID8023000 TK.Half.Life NA 94.24 hours 1compartment NA NA Human Human +DTXSID8023000 Css NA 3.442 mg/L 3compartmentss NA 50% Human Human +DTXSID8023000 Css NA 20.61 mg/L 3compartmentss NA 95% Human Human +DTXSID8023000 Css NA 2.387 mg/L PBTK NA 50% Human Human +DTXSID8023000 Css NA 14.36 mg/L PBTK NA 95% Human Human +DTXSID8023000 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023000 Fup 0.012 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023000 Vd NA 2.333 L/kg 1compartment NA NA Rat Human +DTXSID8023000 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID8023000 TK.Half.Life NA 12.74 hours 1compartment NA NA Rat Human +DTXSID8023000 Css NA 0.4505 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023000 Css NA 2.195 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023000 Css NA 0.3092 mg/L PBTK NA 50% Rat Human +DTXSID8023000 Css NA 1.525 mg/L PBTK NA 95% Rat Human +DTXSID8023004 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023004 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023004 Vd NA 4.39 L/kg 1compartment NA NA Human Human +DTXSID8023004 Days.Css NA 23 Days PBTK NA NA Human Human +DTXSID8023004 TK.Half.Life NA 132.3 hours 1compartment NA NA Human Human +DTXSID8023004 Css NA 3.083 mg/L 3compartmentss NA 50% Human Human +DTXSID8023004 Css NA 18.75 mg/L 3compartmentss NA 95% Human Human +DTXSID8023004 Css NA 2.368 mg/L PBTK NA 50% Human Human +DTXSID8023004 Css NA 14.34 mg/L PBTK NA 95% Human Human +DTXSID8023004 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023004 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023004 Vd NA 3.334 L/kg 1compartment NA NA Rat Human +DTXSID8023004 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID8023004 TK.Half.Life NA 17.9 hours 1compartment NA NA Rat Human +DTXSID8023004 Css NA 0.3986 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023004 Css NA 1.977 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023004 Css NA 0.3062 mg/L PBTK NA 50% Rat Human +DTXSID8023004 Css NA 1.556 mg/L PBTK NA 95% Rat Human +DTXSID8023006 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023006 Fup 0.18 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8023006 Vd NA 0.7818 L/kg 1compartment NA NA Human Human +DTXSID8023006 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8023006 TK.Half.Life NA 28.11 hours 1compartment NA NA Human Human +DTXSID8023006 Css NA 3.044 mg/L 3compartmentss NA 50% Human Human +DTXSID8023006 Css NA 10.27 mg/L 3compartmentss NA 95% Human Human +DTXSID8023006 Css NA 2.922 mg/L PBTK NA 50% Human Human +DTXSID8023006 Css NA 9.862 mg/L PBTK NA 95% Human Human +DTXSID8023006 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023006 Fup 0.18 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8023006 Vd NA 0.7815 L/kg 1compartment NA NA Rat Human +DTXSID8023006 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8023006 TK.Half.Life NA 9.573 hours 1compartment NA NA Rat Human +DTXSID8023006 Css NA 0.1844 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023006 Css NA 0.52 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023006 Css NA 0.1833 mg/L PBTK NA 50% Rat Human +DTXSID8023006 Css NA 0.517 mg/L PBTK NA 95% Rat Human +DTXSID8023050 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023050 Fup 0.00896 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023050 Vd NA 0.3844 L/kg 1compartment NA NA Human Human +DTXSID8023050 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023050 TK.Half.Life NA 7.292 hours 1compartment NA NA Human Human +DTXSID8023050 Css NA 3.256 mg/L 3compartmentss NA 50% Human Human +DTXSID8023050 Css NA 33.15 mg/L 3compartmentss NA 95% Human Human +DTXSID8023050 Css NA 1.98 mg/L PBTK NA 50% Human Human +DTXSID8023050 Css NA 19.46 mg/L PBTK NA 95% Human Human +DTXSID8023050 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023050 Fup 0.00896 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023050 Vd NA 0.3425 L/kg 1compartment NA NA Rat Human +DTXSID8023050 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023050 TK.Half.Life NA 4.332 hours 1compartment NA NA Rat Human +DTXSID8023050 Css NA 0.4383 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023050 Css NA 3.526 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023050 Css NA 0.2566 mg/L PBTK NA 50% Rat Human +DTXSID8023050 Css NA 2.005 mg/L PBTK NA 95% Rat Human +DTXSID8023054 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8023054 Fup 0.52 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8023054 Vd NA 4.051 L/kg 1compartment NA NA Human Human DTXSID8023054 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023054 TK.Half.Life NA 3.027 hours 1compartment NA NA Human Human -DTXSID8023054 Css NA 0.01638 mg/L 3compartmentss NA 50% Human Human -DTXSID8023054 Css NA 0.1026 mg/L 3compartmentss NA 95% Human Human -DTXSID8023054 Css NA 0.0102 mg/L PBTK NA 50% Human Human -DTXSID8023054 Css NA 0.0628 mg/L PBTK NA 95% Human Human -DTXSID8023054 Clint NA 218.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8023054 TK.Half.Life NA 7.551 hours 1compartment NA NA Human Human +DTXSID8023054 Css NA 0.121 mg/L 3compartmentss NA 50% Human Human +DTXSID8023054 Css NA 0.7475 mg/L 3compartmentss NA 95% Human Human +DTXSID8023054 Css NA 0.1076 mg/L PBTK NA 50% Human Human +DTXSID8023054 Css NA 0.6651 mg/L PBTK NA 95% Human Human +DTXSID8023054 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8023054 Fup 0.52 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8023054 Vd NA 3.465 L/kg 1compartment NA NA Rat Human DTXSID8023054 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023054 TK.Half.Life NA 1.03 hours 1compartment NA NA Rat Human -DTXSID8023054 Css NA 0.0103 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023054 Css NA 0.05598 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023054 Css NA 0.006068 mg/L PBTK NA 50% Rat Human -DTXSID8023054 Css NA 0.03294 mg/L PBTK NA 95% Rat Human -DTXSID8023137 Clint NA 53.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023137 Fup NA 0.0586 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023137 Vd NA 1.523 L/kg 1compartment NA NA Human Human +DTXSID8023054 TK.Half.Life NA 1.935 hours 1compartment NA NA Rat Human +DTXSID8023054 Css NA 0.01488 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023054 Css NA 0.07418 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023054 Css NA 0.01372 mg/L PBTK NA 50% Rat Human +DTXSID8023054 Css NA 0.06839 mg/L PBTK NA 95% Rat Human +DTXSID8023056 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023056 Fup 0.043 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8023056 Vd NA 0.2734 L/kg 1compartment NA NA Human Human +DTXSID8023056 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023056 TK.Half.Life NA 3.838 hours 1compartment NA NA Human Human +DTXSID8023056 Css NA 2.054 mg/L 3compartmentss NA 50% Human Human +DTXSID8023056 Css NA 14.07 mg/L 3compartmentss NA 95% Human Human +DTXSID8023056 Css NA 1.25 mg/L PBTK NA 50% Human Human +DTXSID8023056 Css NA 8.159 mg/L PBTK NA 95% Human Human +DTXSID8023056 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023056 Fup 0.043 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8023056 Vd NA 0.2674 L/kg 1compartment NA NA Rat Human +DTXSID8023056 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023056 TK.Half.Life NA 2.354 hours 1compartment NA NA Rat Human +DTXSID8023056 Css NA 0.09486 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023056 Css NA 0.7417 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023056 Css NA 0.05504 mg/L PBTK NA 50% Rat Human +DTXSID8023056 Css NA 0.4217 mg/L PBTK NA 95% Rat Human +DTXSID8023133 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023133 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8023133 Vd NA 2.093 L/kg 1compartment NA NA Human Human +DTXSID8023133 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023133 TK.Half.Life NA 2.253 hours 1compartment NA NA Human Human +DTXSID8023133 Css NA 0.06665 mg/L 3compartmentss NA 50% Human Human +DTXSID8023133 Css NA 0.495 mg/L 3compartmentss NA 95% Human Human +DTXSID8023133 Css NA 0.07082 mg/L PBTK NA 50% Human Human +DTXSID8023133 Css NA 0.5289 mg/L PBTK NA 95% Human Human +DTXSID8023133 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023133 Fup 0.86 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8023133 Vd NA 2.116 L/kg 1compartment NA NA Rat Human +DTXSID8023133 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023133 TK.Half.Life NA 1.214 hours 1compartment NA NA Rat Human +DTXSID8023133 Css NA 0.007204 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023133 Css NA 0.03896 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023133 Css NA 0.007984 mg/L PBTK NA 50% Rat Human +DTXSID8023133 Css NA 0.04317 mg/L PBTK NA 95% Rat Human +DTXSID8023135 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023135 Fup 0.57 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8023135 Vd NA 6.174 L/kg 1compartment NA NA Human Human +DTXSID8023135 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023135 TK.Half.Life NA 3.859 hours 1compartment NA NA Human Human +DTXSID8023135 Css NA 0.01777 mg/L 3compartmentss NA 50% Human Human +DTXSID8023135 Css NA 0.2324 mg/L 3compartmentss NA 95% Human Human +DTXSID8023135 Css NA 0.02868 mg/L PBTK NA 50% Human Human +DTXSID8023135 Css NA 0.257 mg/L PBTK NA 95% Human Human +DTXSID8023135 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023135 Fup 0.57 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8023135 Vd NA 6.183 L/kg 1compartment NA NA Rat Human +DTXSID8023135 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023135 TK.Half.Life NA 1.841 hours 1compartment NA NA Rat Human +DTXSID8023135 Css NA 0.002112 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023135 Css NA 0.02297 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023135 Css NA 0.003649 mg/L PBTK NA 50% Rat Human +DTXSID8023135 Css NA 0.02473 mg/L PBTK NA 95% Rat Human +DTXSID8023137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023137 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023137 Vd NA 2.004 L/kg 1compartment NA NA Human Human DTXSID8023137 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023137 TK.Half.Life NA 3.32 hours 1compartment NA NA Human Human -DTXSID8023137 Css NA 0.2186 mg/L 3compartmentss NA 50% Human Human -DTXSID8023137 Css NA 1.675 mg/L 3compartmentss NA 95% Human Human -DTXSID8023137 Css NA 0.1422 mg/L PBTK NA 50% Human Human -DTXSID8023137 Css NA 1.046 mg/L PBTK NA 95% Human Human -DTXSID8023137 Clint NA 53.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023137 Fup NA 0.0586 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023137 Vd NA 1.182 L/kg 1compartment NA NA Rat Human +DTXSID8023137 TK.Half.Life NA 4.035 hours 1compartment NA NA Human Human +DTXSID8023137 Css NA 0.1492 mg/L 3compartmentss NA 50% Human Human +DTXSID8023137 Css NA 1.026 mg/L 3compartmentss NA 95% Human Human +DTXSID8023137 Css NA 0.1095 mg/L PBTK NA 50% Human Human +DTXSID8023137 Css NA 0.723 mg/L PBTK NA 95% Human Human +DTXSID8023137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023137 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023137 Vd NA 1.609 L/kg 1compartment NA NA Rat Human DTXSID8023137 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023137 TK.Half.Life NA 1.305 hours 1compartment NA NA Rat Human -DTXSID8023137 Css NA 0.1258 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023137 Css NA 0.7904 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023137 Css NA 0.07711 mg/L PBTK NA 50% Rat Human -DTXSID8023137 Css NA 0.4644 mg/L PBTK NA 95% Rat Human -DTXSID8023181 Clint NA 814.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023181 Fup NA 0.0303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023181 Vd NA 0.6708 L/kg 1compartment NA NA Human Human -DTXSID8023181 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023181 TK.Half.Life NA 0.7297 hours 1compartment NA NA Human Human -DTXSID8023181 Css NA 0.0276 mg/L 3compartmentss NA 50% Human Human -DTXSID8023181 Css NA 0.2824 mg/L 3compartmentss NA 95% Human Human -DTXSID8023181 Css NA 0.01667 mg/L PBTK NA 50% Human Human -DTXSID8023181 Css NA 0.1664 mg/L PBTK NA 95% Human Human -DTXSID8023181 Clint NA 814.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023181 Fup NA 0.0303 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023181 Vd NA 0.5147 L/kg 1compartment NA NA Rat Human -DTXSID8023181 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023181 TK.Half.Life NA 0.2626 hours 1compartment NA NA Rat Human -DTXSID8023181 Css NA 0.01618 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023181 Css NA 0.1349 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023181 Css NA 0.009118 mg/L PBTK NA 50% Rat Human -DTXSID8023181 Css NA 0.07448 mg/L PBTK NA 95% Rat Human -DTXSID8023183 Clint NA 3943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023183 Fup NA 0.1753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023183 Vd NA 1.482 L/kg 1compartment NA NA Human Human -DTXSID8023183 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023183 TK.Half.Life NA 1.172 hours 1compartment NA NA Human Human -DTXSID8023183 Css NA 0.0008387 mg/L 3compartmentss NA 50% Human Human -DTXSID8023183 Css NA 0.006254 mg/L 3compartmentss NA 95% Human Human -DTXSID8023183 Css NA 0.0005952 mg/L PBTK NA 50% Human Human -DTXSID8023183 Css NA 0.004142 mg/L PBTK NA 95% Human Human -DTXSID8023183 Clint NA 3943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023183 Fup NA 0.1753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023183 Vd NA 1.177 L/kg 1compartment NA NA Rat Human -DTXSID8023183 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023183 TK.Half.Life NA 0.4056 hours 1compartment NA NA Rat Human -DTXSID8023183 Css NA 0.0004778 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023183 Css NA 0.002882 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023183 Css NA 0.0003219 mg/L PBTK NA 50% Rat Human -DTXSID8023183 Css NA 0.001849 mg/L PBTK NA 95% Rat Human +DTXSID8023137 TK.Half.Life NA 1.509 hours 1compartment NA NA Rat Human +DTXSID8023137 Css NA 0.01899 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023137 Css NA 0.0976 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023137 Css NA 0.01404 mg/L PBTK NA 50% Rat Human +DTXSID8023137 Css NA 0.06678 mg/L PBTK NA 95% Rat Human +DTXSID8023181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023181 Fup 0.0578 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023181 Vd NA 3.05 L/kg 1compartment NA NA Human Human +DTXSID8023181 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8023181 TK.Half.Life NA 47.51 hours 1compartment NA NA Human Human +DTXSID8023181 Css NA 1.613 mg/L 3compartmentss NA 50% Human Human +DTXSID8023181 Css NA 10.61 mg/L 3compartmentss NA 95% Human Human +DTXSID8023181 Css NA 1.116 mg/L PBTK NA 50% Human Human +DTXSID8023181 Css NA 7.236 mg/L PBTK NA 95% Human Human +DTXSID8023181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023181 Fup 0.0578 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023181 Vd NA 2.285 L/kg 1compartment NA NA Rat Human +DTXSID8023181 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8023181 TK.Half.Life NA 7.266 hours 1compartment NA NA Rat Human +DTXSID8023181 Css NA 0.08091 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023181 Css NA 0.5654 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023181 Css NA 0.05457 mg/L PBTK NA 50% Rat Human +DTXSID8023181 Css NA 0.3662 mg/L PBTK NA 95% Rat Human +DTXSID8023183 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023183 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023183 Vd NA 1.89 L/kg 1compartment NA NA Human Human +DTXSID8023183 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID8023183 TK.Half.Life NA 63.19 hours 1compartment NA NA Human Human +DTXSID8023183 Css NA 3.063 mg/L 3compartmentss NA 50% Human Human +DTXSID8023183 Css NA 11.31 mg/L 3compartmentss NA 95% Human Human +DTXSID8023183 Css NA 2.372 mg/L PBTK NA 50% Human Human +DTXSID8023183 Css NA 7.533 mg/L PBTK NA 95% Human Human +DTXSID8023183 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023183 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023183 Vd NA 1.51 L/kg 1compartment NA NA Rat Human +DTXSID8023183 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8023183 TK.Half.Life NA 12.7 hours 1compartment NA NA Rat Human +DTXSID8023183 Css NA 0.07314 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023183 Css NA 0.3684 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023183 Css NA 0.05535 mg/L PBTK NA 50% Rat Human +DTXSID8023183 Css NA 0.2486 mg/L PBTK NA 95% Rat Human DTXSID8023185 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8023185 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023185 Vd NA 0.9173 L/kg 1compartment NA NA Human Human +DTXSID8023185 Vd NA 0.7779 L/kg 1compartment NA NA Human Human DTXSID8023185 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023185 TK.Half.Life NA 5.934 hours 1compartment NA NA Human Human -DTXSID8023185 Css NA 0.8129 mg/L 3compartmentss NA 50% Human Human -DTXSID8023185 Css NA 5.505 mg/L 3compartmentss NA 95% Human Human -DTXSID8023185 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID8023185 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID8023185 TK.Half.Life NA 5.034 hours 1compartment NA NA Human Human +DTXSID8023185 Css NA 0.7016 mg/L 3compartmentss NA 50% Human Human +DTXSID8023185 Css NA 5.049 mg/L 3compartmentss NA 95% Human Human +DTXSID8023185 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID8023185 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID8023185 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8023185 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023185 Vd NA 0.9615 L/kg 1compartment NA NA Rat Human +DTXSID8023185 Vd NA 0.8418 L/kg 1compartment NA NA Rat Human DTXSID8023185 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023185 TK.Half.Life NA 2.12 hours 1compartment NA NA Rat Human -DTXSID8023185 Css NA 0.2036 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023185 Css NA 1.298 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023185 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID8023185 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID8023187 Clint NA 4.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8023185 TK.Half.Life NA 1.856 hours 1compartment NA NA Rat Human +DTXSID8023185 Css NA 0.01286 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023185 Css NA 0.09958 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023185 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID8023185 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID8023187 Clint 11 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID8023187 Fup 0.88 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID8023187 Vd NA 5.409 L/kg 1compartment NA NA Human Human +DTXSID8023187 Vd NA 5.391 L/kg 1compartment NA NA Human Human DTXSID8023187 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023187 TK.Half.Life NA 7.461 hours 1compartment NA NA Human Human -DTXSID8023187 Css NA 0.1159 mg/L 3compartmentss NA 50% Human Human -DTXSID8023187 Css NA 0.8801 mg/L 3compartmentss NA 95% Human Human -DTXSID8023187 Css NA 0.08678 mg/L PBTK NA 50% Human Human -DTXSID8023187 Css NA 0.5896 mg/L PBTK NA 95% Human Human -DTXSID8023187 Clint NA 4.942 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8023187 TK.Half.Life NA 5.307 hours 1compartment NA NA Human Human +DTXSID8023187 Css NA 0.04889 mg/L 3compartmentss NA 50% Human Human +DTXSID8023187 Css NA 0.3806 mg/L 3compartmentss NA 95% Human Human +DTXSID8023187 Css NA 0.03976 mg/L PBTK NA 50% Human Human +DTXSID8023187 Css NA 0.3118 mg/L PBTK NA 95% Human Human +DTXSID8023187 Clint 11 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID8023187 Fup 0.88 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human -DTXSID8023187 Vd NA 5.478 L/kg 1compartment NA NA Rat Human +DTXSID8023187 Vd NA 5.461 L/kg 1compartment NA NA Rat Human DTXSID8023187 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023187 TK.Half.Life NA 3.662 hours 1compartment NA NA Rat Human -DTXSID8023187 Css NA 0.05516 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023187 Css NA 0.3503 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023187 Css NA 0.04062 mg/L PBTK NA 50% Rat Human -DTXSID8023187 Css NA 0.2129 mg/L PBTK NA 95% Rat Human +DTXSID8023187 TK.Half.Life NA 2.547 hours 1compartment NA NA Rat Human +DTXSID8023187 Css NA 0.005512 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023187 Css NA 0.03586 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023187 Css NA 0.004686 mg/L PBTK NA 50% Rat Human +DTXSID8023187 Css NA 0.03046 mg/L PBTK NA 95% Rat Human +DTXSID8023189 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023189 Fup 0.0068 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8023189 Vd NA 0.4268 L/kg 1compartment NA NA Human Human +DTXSID8023189 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8023189 TK.Half.Life NA 9.861 hours 1compartment NA NA Human Human +DTXSID8023189 Css NA 4.132 mg/L 3compartmentss NA 50% Human Human +DTXSID8023189 Css NA 39.85 mg/L 3compartmentss NA 95% Human Human +DTXSID8023189 Css NA 2.428 mg/L PBTK NA 50% Human Human +DTXSID8023189 Css NA 23.11 mg/L PBTK NA 95% Human Human +DTXSID8023189 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023189 Fup 0.0068 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8023189 Vd NA 0.3297 L/kg 1compartment NA NA Rat Human +DTXSID8023189 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023189 TK.Half.Life NA 5.034 hours 1compartment NA NA Rat Human +DTXSID8023189 Css NA 0.4887 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023189 Css NA 3.993 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023189 Css NA 0.2766 mg/L PBTK NA 50% Rat Human +DTXSID8023189 Css NA 2.239 mg/L PBTK NA 95% Rat Human DTXSID8023214 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8023214 Fup 2.42e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8023214 Vd NA 0.5816 L/kg 1compartment NA NA Human Human +DTXSID8023214 Vd NA 0.2505 L/kg 1compartment NA NA Human Human DTXSID8023214 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8023214 TK.Half.Life NA 37650 hours 1compartment NA NA Human Human -DTXSID8023214 Css NA 5014 mg/L 3compartmentss NA 50% Human Human -DTXSID8023214 Css NA 13790 mg/L 3compartmentss NA 95% Human Human -DTXSID8023214 Css NA 3013 mg/L PBTK NA 50% Human Human -DTXSID8023214 Css NA 7911 mg/L PBTK NA 95% Human Human +DTXSID8023214 TK.Half.Life NA 16210 hours 1compartment NA NA Human Human +DTXSID8023214 Css NA 3962 mg/L 3compartmentss NA 50% Human Human +DTXSID8023214 Css NA 11900 mg/L 3compartmentss NA 95% Human Human +DTXSID8023214 Css NA 2336 mg/L PBTK NA 50% Human Human +DTXSID8023214 Css NA 6773 mg/L PBTK NA 95% Human Human DTXSID8023214 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8023214 Fup 2.42e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8023214 Vd NA 0.4275 L/kg 1compartment NA NA Rat Human -DTXSID8023214 Days.Css NA 2600 Days PBTK NA NA Rat Human -DTXSID8023214 TK.Half.Life NA 9425 hours 1compartment NA NA Rat Human -DTXSID8023214 Css NA 1875 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023214 Css NA 2419 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023214 Css NA 1031 mg/L PBTK NA 50% Rat Human -DTXSID8023214 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID8023214 Vd NA 0.2077 L/kg 1compartment NA NA Rat Human +DTXSID8023214 Days.Css NA 1263 Days PBTK NA NA Rat Human +DTXSID8023214 TK.Half.Life NA 4578 hours 1compartment NA NA Rat Human +DTXSID8023214 Css NA 59.62 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023214 Css NA 409 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023214 Css NA 32.53 mg/L PBTK NA 50% Rat Human +DTXSID8023214 Css NA 227.3 mg/L PBTK NA 95% Rat Human DTXSID8023216 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8023216 Fup 3.46e-05 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8023216 Vd NA 0.2199 L/kg 1compartment NA NA Human Human -DTXSID8023216 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8023216 TK.Half.Life NA 14230 hours 1compartment NA NA Human Human -DTXSID8023216 Css NA 131.4 mg/L 3compartmentss NA 50% Human Human -DTXSID8023216 Css NA 997.8 mg/L 3compartmentss NA 95% Human Human -DTXSID8023216 Css NA 81.91 mg/L PBTK NA 50% Human Human -DTXSID8023216 Css NA 584.4 mg/L PBTK NA 95% Human Human +DTXSID8023216 Vd NA 0.1591 L/kg 1compartment NA NA Human Human +DTXSID8023216 Days.Css NA 2843 Days PBTK NA NA Human Human +DTXSID8023216 TK.Half.Life NA 10300 hours 1compartment NA NA Human Human +DTXSID8023216 Css NA 43.04 mg/L 3compartmentss NA 50% Human Human +DTXSID8023216 Css NA 427.2 mg/L 3compartmentss NA 95% Human Human +DTXSID8023216 Css NA 24.94 mg/L PBTK NA 50% Human Human +DTXSID8023216 Css NA 243.7 mg/L PBTK NA 95% Human Human DTXSID8023216 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8023216 Fup 3.46e-05 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8023216 Vd NA 0.1898 L/kg 1compartment NA NA Rat Human -DTXSID8023216 Days.Css NA 1156 Days PBTK NA NA Rat Human -DTXSID8023216 TK.Half.Life NA 4186 hours 1compartment NA NA Rat Human -DTXSID8023216 Css NA 36.44 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023216 Css NA 278.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023216 Css NA 21.24 mg/L PBTK NA 50% Rat Human -DTXSID8023216 Css NA 152 mg/L PBTK NA 95% Rat Human -DTXSID8023260 Clint NA 7.467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023260 Fup NA 0.1847 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023260 Vd NA 0.8271 L/kg 1compartment NA NA Human Human +DTXSID8023216 Vd NA 0.1577 L/kg 1compartment NA NA Rat Human +DTXSID8023216 Days.Css NA 960 Days PBTK NA NA Rat Human +DTXSID8023216 TK.Half.Life NA 3476 hours 1compartment NA NA Rat Human +DTXSID8023216 Css NA 0.2042 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023216 Css NA 2.02 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023216 Css NA 0.1111 mg/L PBTK NA 50% Rat Human +DTXSID8023216 Css NA 1.094 mg/L PBTK NA 95% Rat Human +DTXSID8023260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023260 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023260 Vd NA 1.08 L/kg 1compartment NA NA Human Human DTXSID8023260 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023260 TK.Half.Life NA 2.792 hours 1compartment NA NA Human Human -DTXSID8023260 Css NA 0.3454 mg/L 3compartmentss NA 50% Human Human -DTXSID8023260 Css NA 2.053 mg/L 3compartmentss NA 95% Human Human -DTXSID8023260 Css NA 0.2368 mg/L PBTK NA 50% Human Human -DTXSID8023260 Css NA 1.329 mg/L PBTK NA 95% Human Human -DTXSID8023260 Clint NA 7.467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023260 Fup NA 0.1847 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023260 Vd NA 0.6982 L/kg 1compartment NA NA Rat Human +DTXSID8023260 TK.Half.Life NA 1.299 hours 1compartment NA NA Human Human +DTXSID8023260 Css NA 0.05714 mg/L 3compartmentss NA 50% Human Human +DTXSID8023260 Css NA 0.4312 mg/L 3compartmentss NA 95% Human Human +DTXSID8023260 Css NA 0.04379 mg/L PBTK NA 50% Human Human +DTXSID8023260 Css NA 0.2957 mg/L PBTK NA 95% Human Human +DTXSID8023260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023260 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023260 Vd NA 0.9301 L/kg 1compartment NA NA Rat Human DTXSID8023260 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023260 TK.Half.Life NA 1.344 hours 1compartment NA NA Rat Human -DTXSID8023260 Css NA 0.1807 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023260 Css NA 0.804 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023260 Css NA 0.1178 mg/L PBTK NA 50% Rat Human -DTXSID8023260 Css NA 0.4887 mg/L PBTK NA 95% Rat Human -DTXSID8023262 Clint NA 10.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023262 Fup NA 0.084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023262 Vd NA 3.131 L/kg 1compartment NA NA Human Human -DTXSID8023262 Days.Css NA 29 Days PBTK NA NA Human Human -DTXSID8023262 TK.Half.Life NA 156.8 hours 1compartment NA NA Human Human -DTXSID8023262 Css NA 6.212 mg/L 3compartmentss NA 50% Human Human -DTXSID8023262 Css NA 39.17 mg/L 3compartmentss NA 95% Human Human -DTXSID8023262 Css NA 4.32 mg/L PBTK NA 50% Human Human -DTXSID8023262 Css NA 26.25 mg/L PBTK NA 95% Human Human -DTXSID8023262 Clint NA 10.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023262 Fup NA 0.084 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023262 Vd NA 2.347 L/kg 1compartment NA NA Rat Human -DTXSID8023262 Days.Css NA 16 Days PBTK NA NA Rat Human -DTXSID8023262 TK.Half.Life NA 20.44 hours 1compartment NA NA Rat Human -DTXSID8023262 Css NA 3.415 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023262 Css NA 17.54 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023262 Css NA 2.277 mg/L PBTK NA 50% Rat Human -DTXSID8023262 Css NA 11.22 mg/L PBTK NA 95% Rat Human -DTXSID8023345 Clint NA 4.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8023260 TK.Half.Life NA 0.5705 hours 1compartment NA NA Rat Human +DTXSID8023260 Css NA 0.007194 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023260 Css NA 0.04181 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023260 Css NA 0.005498 mg/L PBTK NA 50% Rat Human +DTXSID8023260 Css NA 0.0288 mg/L PBTK NA 95% Rat Human +DTXSID8023262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023262 Fup 0.0524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023262 Vd NA 3.045 L/kg 1compartment NA NA Human Human +DTXSID8023262 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8023262 TK.Half.Life NA 47.35 hours 1compartment NA NA Human Human +DTXSID8023262 Css NA 1.818 mg/L 3compartmentss NA 50% Human Human +DTXSID8023262 Css NA 12.12 mg/L 3compartmentss NA 95% Human Human +DTXSID8023262 Css NA 1.264 mg/L PBTK NA 50% Human Human +DTXSID8023262 Css NA 8.171 mg/L PBTK NA 95% Human Human +DTXSID8023262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023262 Fup 0.0524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023262 Vd NA 2.286 L/kg 1compartment NA NA Rat Human +DTXSID8023262 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8023262 TK.Half.Life NA 7.35 hours 1compartment NA NA Rat Human +DTXSID8023262 Css NA 0.2368 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023262 Css NA 1.376 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023262 Css NA 0.1628 mg/L PBTK NA 50% Rat Human +DTXSID8023262 Css NA 0.9004 mg/L PBTK NA 95% Rat Human +DTXSID8023343 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023343 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8023343 Vd NA 1.33 L/kg 1compartment NA NA Human Human +DTXSID8023343 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023343 TK.Half.Life NA 3.081 hours 1compartment NA NA Human Human +DTXSID8023343 Css NA 0.194 mg/L 3compartmentss NA 50% Human Human +DTXSID8023343 Css NA 1.544 mg/L 3compartmentss NA 95% Human Human +DTXSID8023343 Css NA 0.1298 mg/L PBTK NA 50% Human Human +DTXSID8023343 Css NA 0.9752 mg/L PBTK NA 95% Human Human +DTXSID8023343 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023343 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8023343 Vd NA 1.026 L/kg 1compartment NA NA Rat Human +DTXSID8023343 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023343 TK.Half.Life NA 1.228 hours 1compartment NA NA Rat Human +DTXSID8023343 Css NA 0.00938 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023343 Css NA 0.08147 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023343 Css NA 0.0061 mg/L PBTK NA 50% Rat Human +DTXSID8023343 Css NA 0.0499 mg/L PBTK NA 95% Rat Human +DTXSID8023345 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8023345 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8023345 Vd NA 2.995 L/kg 1compartment NA NA Human Human +DTXSID8023345 Vd NA 2.605 L/kg 1compartment NA NA Human Human DTXSID8023345 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023345 TK.Half.Life NA 5.617 hours 1compartment NA NA Human Human -DTXSID8023345 Css NA 0.1201 mg/L 3compartmentss NA 50% Human Human -DTXSID8023345 Css NA 1.019 mg/L 3compartmentss NA 95% Human Human -DTXSID8023345 Css NA 0.1365 mg/L PBTK NA 50% Human Human -DTXSID8023345 Css NA 0.8475 mg/L PBTK NA 95% Human Human -DTXSID8023345 Clint NA 4.556 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8023345 TK.Half.Life NA 4.014 hours 1compartment NA NA Human Human +DTXSID8023345 Css NA 0.09404 mg/L 3compartmentss NA 50% Human Human +DTXSID8023345 Css NA 0.8209 mg/L 3compartmentss NA 95% Human Human +DTXSID8023345 Css NA 0.09974 mg/L PBTK NA 50% Human Human +DTXSID8023345 Css NA 0.6486 mg/L PBTK NA 95% Human Human +DTXSID8023345 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8023345 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8023345 Vd NA 3.018 L/kg 1compartment NA NA Rat Human +DTXSID8023345 Vd NA 2.631 L/kg 1compartment NA NA Rat Human DTXSID8023345 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023345 TK.Half.Life NA 3.158 hours 1compartment NA NA Rat Human -DTXSID8023345 Css NA 0.05709 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023345 Css NA 0.4092 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023345 Css NA 0.06444 mg/L PBTK NA 50% Rat Human -DTXSID8023345 Css NA 0.2989 mg/L PBTK NA 95% Rat Human -DTXSID8023347 Clint NA 4.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8023345 TK.Half.Life NA 2.281 hours 1compartment NA NA Rat Human +DTXSID8023345 Css NA 0.01058 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023345 Css NA 0.07574 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023345 Css NA 0.01159 mg/L PBTK NA 50% Rat Human +DTXSID8023345 Css NA 0.05726 mg/L PBTK NA 95% Rat Human +DTXSID8023347 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8023347 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8023347 Vd NA 5.722 L/kg 1compartment NA NA Human Human +DTXSID8023347 Vd NA 6.109 L/kg 1compartment NA NA Human Human DTXSID8023347 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023347 TK.Half.Life NA 9.348 hours 1compartment NA NA Human Human -DTXSID8023347 Css NA 0.121 mg/L 3compartmentss NA 50% Human Human -DTXSID8023347 Css NA 1.14 mg/L 3compartmentss NA 95% Human Human -DTXSID8023347 Css NA 0.1186 mg/L PBTK NA 50% Human Human -DTXSID8023347 Css NA 0.8405 mg/L PBTK NA 95% Human Human -DTXSID8023347 Clint NA 4.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8023347 TK.Half.Life NA 8.417 hours 1compartment NA NA Human Human +DTXSID8023347 Css NA 0.07799 mg/L 3compartmentss NA 50% Human Human +DTXSID8023347 Css NA 0.5853 mg/L 3compartmentss NA 95% Human Human +DTXSID8023347 Css NA 0.08613 mg/L PBTK NA 50% Human Human +DTXSID8023347 Css NA 0.6492 mg/L PBTK NA 95% Human Human +DTXSID8023347 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8023347 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8023347 Vd NA 5.798 L/kg 1compartment NA NA Rat Human +DTXSID8023347 Vd NA 6.144 L/kg 1compartment NA NA Rat Human DTXSID8023347 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023347 TK.Half.Life NA 4.794 hours 1compartment NA NA Rat Human -DTXSID8023347 Css NA 0.05708 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023347 Css NA 0.4581 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023347 Css NA 0.05556 mg/L PBTK NA 50% Rat Human -DTXSID8023347 Css NA 0.307 mg/L PBTK NA 95% Rat Human +DTXSID8023347 TK.Half.Life NA 4.061 hours 1compartment NA NA Rat Human +DTXSID8023347 Css NA 0.008929 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023347 Css NA 0.04944 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023347 Css NA 0.01027 mg/L PBTK NA 50% Rat Human +DTXSID8023347 Css NA 0.05684 mg/L PBTK NA 95% Rat Human DTXSID8023349 Clint 65.03 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8023349 Fup 0.559 NA NA https://doi.org/10.1124/dmd.30.8.892 NA Human Human DTXSID8023349 Vd NA 3.265 L/kg 1compartment NA NA Human Human DTXSID8023349 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8023349 TK.Half.Life NA 1.811 hours 1compartment NA NA Human Human -DTXSID8023349 Css NA 0.002144 mg/L 3compartmentss NA 50% Human Human -DTXSID8023349 Css NA 0.02605 mg/L 3compartmentss NA 95% Human Human -DTXSID8023349 Css NA 0.002271 mg/L PBTK NA 50% Human Human -DTXSID8023349 Css NA 0.02093 mg/L PBTK NA 95% Human Human +DTXSID8023349 Css NA 0.007897 mg/L 3compartmentss NA 50% Human Human +DTXSID8023349 Css NA 0.08048 mg/L 3compartmentss NA 95% Human Human +DTXSID8023349 Css NA 0.009596 mg/L PBTK NA 50% Human Human +DTXSID8023349 Css NA 0.09815 mg/L PBTK NA 95% Human Human DTXSID8023349 Clint 265.2 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8023349 Fup 0.62 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8023349 Vd NA 3.364 L/kg 1compartment NA NA Rat Rat DTXSID8023349 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID8023349 TK.Half.Life NA 0.6897 hours 1compartment NA NA Rat Rat -DTXSID8023349 Css NA 0.001299 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8023349 Css NA 0.01412 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8023349 Css NA 0.001358 mg/L PBTK NA 50% Rat Rat -DTXSID8023349 Css NA 0.01082 mg/L PBTK NA 95% Rat Rat +DTXSID8023349 Css NA 0.0001668 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8023349 Css NA 0.002003 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8023349 Css NA 0.0002138 mg/L PBTK NA 50% Rat Rat +DTXSID8023349 Css NA 0.002537 mg/L PBTK NA 95% Rat Rat +DTXSID8023391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023391 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8023391 Vd NA 0.2075 L/kg 1compartment NA NA Human Human +DTXSID8023391 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023391 TK.Half.Life NA 3.823 hours 1compartment NA NA Human Human +DTXSID8023391 Css NA 1.428 mg/L 3compartmentss NA 50% Human Human +DTXSID8023391 Css NA 15.08 mg/L 3compartmentss NA 95% Human Human +DTXSID8023391 Css NA 0.834 mg/L PBTK NA 50% Human Human +DTXSID8023391 Css NA 8.706 mg/L PBTK NA 95% Human Human +DTXSID8023391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023391 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8023391 Vd NA 0.2024 L/kg 1compartment NA NA Rat Human +DTXSID8023391 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023391 TK.Half.Life NA 2.495 hours 1compartment NA NA Rat Human +DTXSID8023391 Css NA 0.01404 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023391 Css NA 0.1245 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023391 Css NA 0.007739 mg/L PBTK NA 50% Rat Human +DTXSID8023391 Css NA 0.0678 mg/L PBTK NA 95% Rat Human DTXSID8023393 Clint 1.402 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8023393 Fup 0.25 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human -DTXSID8023393 Vd NA 2.914 L/kg 1compartment NA NA Human Human -DTXSID8023393 Days.Css NA 20 Days PBTK NA NA Human Human -DTXSID8023393 TK.Half.Life NA 110.3 hours 1compartment NA NA Human Human -DTXSID8023393 Css NA 4.836 mg/L 3compartmentss NA 50% Human Human -DTXSID8023393 Css NA 17.34 mg/L 3compartmentss NA 95% Human Human -DTXSID8023393 Css NA 2.98 mg/L PBTK NA 50% Human Human -DTXSID8023393 Css NA 10.51 mg/L PBTK NA 95% Human Human +DTXSID8023393 Vd NA 2.827 L/kg 1compartment NA NA Human Human +DTXSID8023393 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID8023393 TK.Half.Life NA 84.98 hours 1compartment NA NA Human Human +DTXSID8023393 Css NA 2.932 mg/L 3compartmentss NA 50% Human Human +DTXSID8023393 Css NA 10.73 mg/L 3compartmentss NA 95% Human Human +DTXSID8023393 Css NA 2.432 mg/L PBTK NA 50% Human Human +DTXSID8023393 Css NA 8.904 mg/L PBTK NA 95% Human Human DTXSID8023393 Clint 1.402 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID8023393 Fup 0.25 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human -DTXSID8023393 Vd NA 2.214 L/kg 1compartment NA NA Rat Human -DTXSID8023393 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID8023393 TK.Half.Life NA 16.96 hours 1compartment NA NA Rat Human -DTXSID8023393 Css NA 2.364 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023393 Css NA 5.833 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023393 Css NA 1.376 mg/L PBTK NA 50% Rat Human -DTXSID8023393 Css NA 3.3 mg/L PBTK NA 95% Rat Human -DTXSID8023395 Clint NA 493 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023395 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023395 Vd NA 3.09 L/kg 1compartment NA NA Human Human -DTXSID8023395 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023395 TK.Half.Life NA 6.484 hours 1compartment NA NA Human Human -DTXSID8023395 Css NA 0.1599 mg/L 3compartmentss NA 50% Human Human -DTXSID8023395 Css NA 0.9667 mg/L 3compartmentss NA 95% Human Human -DTXSID8023395 Css NA 0.1106 mg/L PBTK NA 50% Human Human -DTXSID8023395 Css NA 0.6532 mg/L PBTK NA 95% Human Human -DTXSID8023395 Clint NA 493 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023395 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023395 Vd NA 2.314 L/kg 1compartment NA NA Rat Human -DTXSID8023395 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023395 TK.Half.Life NA 1.365 hours 1compartment NA NA Rat Human -DTXSID8023395 Css NA 0.09104 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023395 Css NA 0.4021 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023395 Css NA 0.06022 mg/L PBTK NA 50% Rat Human -DTXSID8023395 Css NA 0.2647 mg/L PBTK NA 95% Rat Human -DTXSID8023422 Clint NA 0.8921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023422 Fup NA 0.1469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023422 Vd NA 1.225 L/kg 1compartment NA NA Human Human -DTXSID8023422 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8023422 TK.Half.Life NA 25.34 hours 1compartment NA NA Human Human -DTXSID8023422 Css NA 2.832 mg/L 3compartmentss NA 50% Human Human -DTXSID8023422 Css NA 13.16 mg/L 3compartmentss NA 95% Human Human -DTXSID8023422 Css NA 1.912 mg/L PBTK NA 50% Human Human -DTXSID8023422 Css NA 8.137 mg/L PBTK NA 95% Human Human -DTXSID8023422 Clint NA 0.8921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023422 Fup NA 0.1469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023422 Vd NA 0.9589 L/kg 1compartment NA NA Rat Human +DTXSID8023393 Vd 0.025 2.156 L/kg 1compartment Wambaugh et al. (2018) NA Rat Human +DTXSID8023393 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID8023393 TK.Half.Life 0.0093 14.37 hours 1compartment Wambaugh et al. (2018) NA Rat Human +DTXSID8023393 Css 0.022 0.2943 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Human +DTXSID8023393 Css 0.022 0.7141 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Human +DTXSID8023393 Css 0.022 0.253 mg/L PBTK Wambaugh et al. (2018) 50% Rat Human +DTXSID8023393 Css 0.022 0.6137 mg/L PBTK Wambaugh et al. (2018) 95% Rat Human +DTXSID8023395 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023395 Fup 0.017 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023395 Vd NA 293.7 L/kg 1compartment NA NA Human Human +DTXSID8023395 Days.Css NA 2333 Days PBTK NA NA Human Human +DTXSID8023395 TK.Half.Life NA 8593 hours 1compartment NA NA Human Human +DTXSID8023395 Css NA 0.05879 mg/L 3compartmentss NA 50% Human Human +DTXSID8023395 Css NA 0.3879 mg/L 3compartmentss NA 95% Human Human +DTXSID8023395 Css NA 2.385 mg/L PBTK NA 50% Human Human +DTXSID8023395 Css NA 14.2 mg/L PBTK NA 95% Human Human +DTXSID8023395 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023395 Fup 0.017 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023395 Vd NA 262 L/kg 1compartment NA NA Rat Human +DTXSID8023395 Days.Css NA 1482 Days PBTK NA NA Rat Human +DTXSID8023395 TK.Half.Life NA 1318 hours 1compartment NA NA Rat Human +DTXSID8023395 Css NA 0.006818 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023395 Css NA 0.03384 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023395 Css NA 0.3112 mg/L PBTK NA 50% Rat Human +DTXSID8023395 Css NA 1.573 mg/L PBTK NA 95% Rat Human +DTXSID8023397 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023397 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8023397 Vd NA 0.2807 L/kg 1compartment NA NA Human Human +DTXSID8023397 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023397 TK.Half.Life NA 2.501 hours 1compartment NA NA Human Human +DTXSID8023397 Css NA 1.192 mg/L 3compartmentss NA 50% Human Human +DTXSID8023397 Css NA 8.012 mg/L 3compartmentss NA 95% Human Human +DTXSID8023397 Css NA 0.7318 mg/L PBTK NA 50% Human Human +DTXSID8023397 Css NA 4.793 mg/L PBTK NA 95% Human Human +DTXSID8023397 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023397 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8023397 Vd NA 0.2751 L/kg 1compartment NA NA Rat Human +DTXSID8023397 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023397 TK.Half.Life NA 1.517 hours 1compartment NA NA Rat Human +DTXSID8023397 Css NA 0.05494 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023397 Css NA 0.4146 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023397 Css NA 0.0323 mg/L PBTK NA 50% Rat Human +DTXSID8023397 Css NA 0.2384 mg/L PBTK NA 95% Rat Human +DTXSID8023422 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023422 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023422 Vd NA 1.508 L/kg 1compartment NA NA Human Human +DTXSID8023422 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID8023422 TK.Half.Life NA 56.86 hours 1compartment NA NA Human Human +DTXSID8023422 Css NA 4.14 mg/L 3compartmentss NA 50% Human Human +DTXSID8023422 Css NA 14.3 mg/L 3compartmentss NA 95% Human Human +DTXSID8023422 Css NA 3.014 mg/L PBTK NA 50% Human Human +DTXSID8023422 Css NA 9.251 mg/L PBTK NA 95% Human Human +DTXSID8023422 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023422 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023422 Vd NA 1.187 L/kg 1compartment NA NA Rat Human DTXSID8023422 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8023422 TK.Half.Life NA 8.503 hours 1compartment NA NA Rat Human -DTXSID8023422 Css NA 1.151 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023422 Css NA 4.426 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023422 Css NA 0.7318 mg/L PBTK NA 50% Rat Human -DTXSID8023422 Css NA 2.539 mg/L PBTK NA 95% Rat Human -DTXSID8023426 Clint NA 11.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023426 Fup NA 0.3685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023426 Vd NA 1.512 L/kg 1compartment NA NA Human Human +DTXSID8023422 TK.Half.Life NA 12.3 hours 1compartment NA NA Rat Human +DTXSID8023422 Css NA 0.2652 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023422 Css NA 0.7641 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023422 Css NA 0.19 mg/L PBTK NA 50% Rat Human +DTXSID8023422 Css NA 0.4755 mg/L PBTK NA 95% Rat Human +DTXSID8023426 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023426 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023426 Vd NA 1.103 L/kg 1compartment NA NA Human Human DTXSID8023426 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023426 TK.Half.Life NA 2.528 hours 1compartment NA NA Human Human -DTXSID8023426 Css NA 0.1185 mg/L 3compartmentss NA 50% Human Human -DTXSID8023426 Css NA 0.7903 mg/L 3compartmentss NA 95% Human Human -DTXSID8023426 Css NA 0.09294 mg/L PBTK NA 50% Human Human -DTXSID8023426 Css NA 0.5588 mg/L PBTK NA 95% Human Human -DTXSID8023426 Clint NA 11.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023426 Fup NA 0.3685 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023426 Vd NA 1.238 L/kg 1compartment NA NA Rat Human +DTXSID8023426 TK.Half.Life NA 1.86 hours 1compartment NA NA Human Human +DTXSID8023426 Css NA 0.1116 mg/L 3compartmentss NA 50% Human Human +DTXSID8023426 Css NA 0.7774 mg/L 3compartmentss NA 95% Human Human +DTXSID8023426 Css NA 0.07867 mg/L PBTK NA 50% Human Human +DTXSID8023426 Css NA 0.5124 mg/L PBTK NA 95% Human Human +DTXSID8023426 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023426 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023426 Vd NA 0.8974 L/kg 1compartment NA NA Rat Human DTXSID8023426 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023426 TK.Half.Life NA 1.029 hours 1compartment NA NA Rat Human -DTXSID8023426 Css NA 0.06172 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023426 Css NA 0.3188 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023426 Css NA 0.04672 mg/L PBTK NA 50% Rat Human -DTXSID8023426 Css NA 0.2139 mg/L PBTK NA 95% Rat Human -DTXSID8023470 Clint NA 17.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023470 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023470 Vd NA 0.1866 L/kg 1compartment NA NA Human Human +DTXSID8023426 TK.Half.Life NA 0.7964 hours 1compartment NA NA Rat Human +DTXSID8023426 Css NA 0.01412 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023426 Css NA 0.07601 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023426 Css NA 0.009856 mg/L PBTK NA 50% Rat Human +DTXSID8023426 Css NA 0.04868 mg/L PBTK NA 95% Rat Human +DTXSID80234280 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80234280 Fup 0.548 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80234280 Vd NA 0.5934 L/kg 1compartment NA NA Human Human +DTXSID80234280 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80234280 TK.Half.Life NA 0.9586 hours 1compartment NA NA Human Human +DTXSID80234280 Css NA 0.1138 mg/L 3compartmentss NA 50% Human Human +DTXSID80234280 Css NA 1.022 mg/L 3compartmentss NA 95% Human Human +DTXSID80234280 Css NA 0.08653 mg/L PBTK NA 50% Human Human +DTXSID80234280 Css NA 0.6683 mg/L PBTK NA 95% Human Human +DTXSID80234280 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80234280 Fup 0.548 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80234280 Vd NA 0.6098 L/kg 1compartment NA NA Rat Human +DTXSID80234280 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80234280 TK.Half.Life NA 0.5348 hours 1compartment NA NA Rat Human +DTXSID80234280 Css NA 0.007517 mg/L 3compartmentss NA 50% Rat Human +DTXSID80234280 Css NA 0.06348 mg/L 3compartmentss NA 95% Rat Human +DTXSID80234280 Css NA 0.005826 mg/L PBTK NA 50% Rat Human +DTXSID80234280 Css NA 0.0396 mg/L PBTK NA 95% Rat Human +DTXSID8023470 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023470 Fup 0.0883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023470 Vd NA 0.2419 L/kg 1compartment NA NA Human Human DTXSID8023470 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023470 TK.Half.Life NA 2.938 hours 1compartment NA NA Human Human -DTXSID8023470 Css NA 2.911 mg/L 3compartmentss NA 50% Human Human -DTXSID8023470 Css NA 27.18 mg/L 3compartmentss NA 95% Human Human -DTXSID8023470 Css NA 1.705 mg/L PBTK NA 50% Human Human -DTXSID8023470 Css NA 15.79 mg/L PBTK NA 95% Human Human -DTXSID8023470 Clint NA 17.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023470 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023470 Vd NA 0.1841 L/kg 1compartment NA NA Rat Human +DTXSID8023470 TK.Half.Life NA 1.653 hours 1compartment NA NA Human Human +DTXSID8023470 Css NA 0.55 mg/L 3compartmentss NA 50% Human Human +DTXSID8023470 Css NA 4.245 mg/L 3compartmentss NA 95% Human Human +DTXSID8023470 Css NA 0.3342 mg/L PBTK NA 50% Human Human +DTXSID8023470 Css NA 2.483 mg/L PBTK NA 95% Human Human +DTXSID8023470 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023470 Fup 0.0883 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023470 Vd NA 0.2445 L/kg 1compartment NA NA Rat Human DTXSID8023470 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023470 TK.Half.Life NA 1.921 hours 1compartment NA NA Rat Human -DTXSID8023470 Css NA 1.617 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023470 Css NA 12.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023470 Css NA 0.8826 mg/L PBTK NA 50% Rat Human -DTXSID8023470 Css NA 6.628 mg/L PBTK NA 95% Rat Human +DTXSID8023470 TK.Half.Life NA 1.026 hours 1compartment NA NA Rat Human +DTXSID8023470 Css NA 0.005753 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023470 Css NA 0.03492 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023470 Css NA 0.003279 mg/L PBTK NA 50% Rat Human +DTXSID8023470 Css NA 0.01939 mg/L PBTK NA 95% Rat Human DTXSID8023472 Clint NA 58.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8023472 Fup NA 0.0069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023472 Vd NA 1812 L/kg 1compartment NA NA Human Human -DTXSID8023472 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8023472 TK.Half.Life NA 19880 hours 1compartment NA NA Human Human -DTXSID8023472 Css NA 0.003011 mg/L 3compartmentss NA 50% Human Human -DTXSID8023472 Css NA 0.01775 mg/L 3compartmentss NA 95% Human Human -DTXSID8023472 Css NA 0.9106 mg/L PBTK NA 50% Human Human -DTXSID8023472 Css NA 4.941 mg/L PBTK NA 95% Human Human +DTXSID8023472 Vd NA 273200 L/kg 1compartment NA NA Human Human +DTXSID8023472 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID8023472 TK.Half.Life NA 3001000 hours 1compartment NA NA Human Human +DTXSID8023472 Css NA 1.398e-05 mg/L 3compartmentss NA 50% Human Human +DTXSID8023472 Css NA 9.078e-05 mg/L 3compartmentss NA 95% Human Human +DTXSID8023472 Css NA 0.7692 mg/L PBTK NA 50% Human Human +DTXSID8023472 Css NA 4.629 mg/L PBTK NA 95% Human Human DTXSID8023472 Clint NA 58.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8023472 Fup NA 0.0069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023472 Vd NA 1676 L/kg 1compartment NA NA Rat Human -DTXSID8023472 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID8023472 TK.Half.Life NA 3270 hours 1compartment NA NA Rat Human -DTXSID8023472 Css NA 0.001522 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023472 Css NA 0.006685 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023472 Css NA 0.4948 mg/L PBTK NA 50% Rat Human -DTXSID8023472 Css NA 2.15 mg/L PBTK NA 95% Rat Human +DTXSID8023472 Vd NA 260400 L/kg 1compartment NA NA Rat Human +DTXSID8023472 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID8023472 TK.Half.Life NA 507800 hours 1compartment NA NA Rat Human +DTXSID8023472 Css NA 4.52e-07 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023472 Css NA 3.476e-06 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023472 Css NA 0.02773 mg/L PBTK NA 50% Rat Human +DTXSID8023472 Css NA 0.1917 mg/L PBTK NA 95% Rat Human DTXSID8023474 Clint 96.82 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID8023474 Fup NA 0.012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023474 Vd NA 4.794 L/kg 1compartment NA NA Human Human -DTXSID8023474 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023474 TK.Half.Life NA 7.187 hours 1compartment NA NA Human Human -DTXSID8023474 Css NA 0.09324 mg/L 3compartmentss NA 50% Human Human -DTXSID8023474 Css NA 0.6337 mg/L 3compartmentss NA 95% Human Human -DTXSID8023474 Css NA 0.0742 mg/L PBTK NA 50% Human Human -DTXSID8023474 Css NA 0.4703 mg/L PBTK NA 95% Human Human +DTXSID8023474 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023474 Vd NA 4.977 L/kg 1compartment NA NA Human Human +DTXSID8023474 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8023474 TK.Half.Life NA 36.03 hours 1compartment NA NA Human Human +DTXSID8023474 Css NA 0.657 mg/L 3compartmentss NA 50% Human Human +DTXSID8023474 Css NA 3.928 mg/L 3compartmentss NA 95% Human Human +DTXSID8023474 Css NA 0.5303 mg/L PBTK NA 50% Human Human +DTXSID8023474 Css NA 3.095 mg/L PBTK NA 95% Human Human DTXSID8023474 Clint 96.82 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID8023474 Fup NA 0.012 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023474 Vd NA 3.689 L/kg 1compartment NA NA Rat Human -DTXSID8023474 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023474 TK.Half.Life NA 1.768 hours 1compartment NA NA Rat Human -DTXSID8023474 Css NA 0.05182 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023474 Css NA 0.2997 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023474 Css NA 0.04008 mg/L PBTK NA 50% Rat Human -DTXSID8023474 Css NA 0.2108 mg/L PBTK NA 95% Rat Human +DTXSID8023474 Fup 0.0157 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023474 Vd NA 3.8 L/kg 1compartment NA NA Rat Human +DTXSID8023474 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8023474 TK.Half.Life NA 5.449 hours 1compartment NA NA Rat Human +DTXSID8023474 Css NA 0.08655 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023474 Css NA 0.4145 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023474 Css NA 0.06967 mg/L PBTK NA 50% Rat Human +DTXSID8023474 Css NA 0.3506 mg/L PBTK NA 95% Rat Human DTXSID8023476 Clint 2.531 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8023476 Fup 0.58 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8023476 Vd NA 3.576 L/kg 1compartment NA NA Human Human DTXSID8023476 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8023476 TK.Half.Life NA 8.83 hours 1compartment NA NA Human Human -DTXSID8023476 Css NA 0.1904 mg/L 3compartmentss NA 50% Human Human -DTXSID8023476 Css NA 1.727 mg/L 3compartmentss NA 95% Human Human -DTXSID8023476 Css NA 0.1836 mg/L PBTK NA 50% Human Human -DTXSID8023476 Css NA 1.198 mg/L PBTK NA 95% Human Human +DTXSID8023476 Css NA 0.1934 mg/L 3compartmentss NA 50% Human Human +DTXSID8023476 Css NA 1.235 mg/L 3compartmentss NA 95% Human Human +DTXSID8023476 Css NA 0.1925 mg/L PBTK NA 50% Human Human +DTXSID8023476 Css NA 1.234 mg/L PBTK NA 95% Human Human DTXSID8023476 Clint 52.29 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8023476 Fup 0.64 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8023476 Vd NA 3.905 L/kg 1compartment NA NA Rat Rat DTXSID8023476 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID8023476 TK.Half.Life NA 1.154 hours 1compartment NA NA Rat Rat -DTXSID8023476 Css NA 0.006058 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8023476 Css NA 0.06888 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8023476 Css NA 0.005676 mg/L PBTK NA 50% Rat Rat -DTXSID8023476 Css NA 0.04864 mg/L PBTK NA 95% Rat Rat -DTXSID8023478 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023478 Fup NA 0.6163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023478 Vd NA 4.578 L/kg 1compartment NA NA Human Human -DTXSID8023478 Days.Css NA 211 Days PBTK NA NA Human Human -DTXSID8023478 TK.Half.Life NA 849.1 hours 1compartment NA NA Human Human -DTXSID8023478 Css NA 15.08 mg/L 3compartmentss NA 50% Human Human -DTXSID8023478 Css NA 48.66 mg/L 3compartmentss NA 95% Human Human -DTXSID8023478 Css NA 15.11 mg/L PBTK NA 50% Human Human -DTXSID8023478 Css NA 40.01 mg/L PBTK NA 95% Human Human -DTXSID8023478 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023478 Fup NA 0.6163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023478 Vd NA 3.974 L/kg 1compartment NA NA Rat Human -DTXSID8023478 Days.Css NA 61 Days PBTK NA NA Rat Human -DTXSID8023478 TK.Half.Life NA 70.72 hours 1compartment NA NA Rat Human -DTXSID8023478 Css NA 3.893 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023478 Css NA 10.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023478 Css NA 3.881 mg/L PBTK NA 50% Rat Human -DTXSID8023478 Css NA 8.038 mg/L PBTK NA 95% Rat Human -DTXSID8023505 Clint NA 61.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023505 Fup NA 0.0565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023505 Vd NA 2.198 L/kg 1compartment NA NA Human Human +DTXSID8023476 Css NA 0.00115 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8023476 Css NA 0.01062 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8023476 Css NA 0.001196 mg/L PBTK NA 50% Rat Rat +DTXSID8023476 Css NA 0.01101 mg/L PBTK NA 95% Rat Rat +DTXSID8023505 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023505 Fup 0.0627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023505 Vd NA 2.264 L/kg 1compartment NA NA Human Human DTXSID8023505 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023505 TK.Half.Life NA 5.462 hours 1compartment NA NA Human Human -DTXSID8023505 Css NA 0.2524 mg/L 3compartmentss NA 50% Human Human -DTXSID8023505 Css NA 1.782 mg/L 3compartmentss NA 95% Human Human -DTXSID8023505 Css NA 0.1678 mg/L PBTK NA 50% Human Human -DTXSID8023505 Css NA 1.128 mg/L PBTK NA 95% Human Human -DTXSID8023505 Clint NA 61.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023505 Fup NA 0.0565 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023505 Vd NA 1.649 L/kg 1compartment NA NA Rat Human +DTXSID8023505 TK.Half.Life NA 11.84 hours 1compartment NA NA Human Human +DTXSID8023505 Css NA 0.642 mg/L 3compartmentss NA 50% Human Human +DTXSID8023505 Css NA 4.147 mg/L 3compartmentss NA 95% Human Human +DTXSID8023505 Css NA 0.4284 mg/L PBTK NA 50% Human Human +DTXSID8023505 Css NA 2.673 mg/L PBTK NA 95% Human Human +DTXSID8023505 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023505 Fup 0.0627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023505 Vd NA 1.699 L/kg 1compartment NA NA Rat Human DTXSID8023505 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023505 TK.Half.Life NA 1.684 hours 1compartment NA NA Rat Human -DTXSID8023505 Css NA 0.1432 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023505 Css NA 0.8273 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023505 Css NA 0.08988 mg/L PBTK NA 50% Rat Human -DTXSID8023505 Css NA 0.505 mg/L PBTK NA 95% Rat Human -DTXSID8023551 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023551 Fup NA 0.16 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023551 Vd NA 0.6787 L/kg 1compartment NA NA Human Human -DTXSID8023551 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8023551 TK.Half.Life NA 28.69 hours 1compartment NA NA Human Human -DTXSID8023551 Css NA 5.64 mg/L 3compartmentss NA 50% Human Human -DTXSID8023551 Css NA 23.63 mg/L 3compartmentss NA 95% Human Human -DTXSID8023551 Css NA 3.708 mg/L PBTK NA 50% Human Human -DTXSID8023551 Css NA 14.21 mg/L PBTK NA 95% Human Human -DTXSID8023551 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023551 Fup NA 0.16 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023551 Vd NA 0.578 L/kg 1compartment NA NA Rat Human +DTXSID8023505 TK.Half.Life NA 3.455 hours 1compartment NA NA Rat Human +DTXSID8023505 Css NA 0.0824 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023505 Css NA 0.4506 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023505 Css NA 0.05417 mg/L PBTK NA 50% Rat Human +DTXSID8023505 Css NA 0.2836 mg/L PBTK NA 95% Rat Human +DTXSID8023509 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023509 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023509 Vd NA 2.882 L/kg 1compartment NA NA Human Human +DTXSID8023509 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023509 TK.Half.Life NA 4.969 hours 1compartment NA NA Human Human +DTXSID8023509 Css NA 0.09928 mg/L 3compartmentss NA 50% Human Human +DTXSID8023509 Css NA 0.8183 mg/L 3compartmentss NA 95% Human Human +DTXSID8023509 Css NA 0.1135 mg/L PBTK NA 50% Human Human +DTXSID8023509 Css NA 0.6916 mg/L PBTK NA 95% Human Human +DTXSID8023509 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023509 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023509 Vd NA 2.898 L/kg 1compartment NA NA Rat Human +DTXSID8023509 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023509 TK.Half.Life NA 2.911 hours 1compartment NA NA Rat Human +DTXSID8023509 Css NA 0.01119 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023509 Css NA 0.07255 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023509 Css NA 0.01329 mg/L PBTK NA 50% Rat Human +DTXSID8023509 Css NA 0.05952 mg/L PBTK NA 95% Rat Human +DTXSID8023551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023551 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023551 Vd NA 1.648 L/kg 1compartment NA NA Human Human +DTXSID8023551 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023551 TK.Half.Life NA 3.014 hours 1compartment NA NA Human Human +DTXSID8023551 Css NA 0.1294 mg/L 3compartmentss NA 50% Human Human +DTXSID8023551 Css NA 0.8766 mg/L 3compartmentss NA 95% Human Human +DTXSID8023551 Css NA 0.09196 mg/L PBTK NA 50% Human Human +DTXSID8023551 Css NA 0.5784 mg/L PBTK NA 95% Human Human +DTXSID8023551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023551 Fup 0.207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023551 Vd NA 1.276 L/kg 1compartment NA NA Rat Human DTXSID8023551 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023551 TK.Half.Life NA 8.05 hours 1compartment NA NA Rat Human -DTXSID8023551 Css NA 1.578 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023551 Css NA 5.252 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023551 Css NA 0.9796 mg/L PBTK NA 50% Rat Human -DTXSID8023551 Css NA 2.976 mg/L PBTK NA 95% Rat Human -DTXSID8023557 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8023551 TK.Half.Life NA 1.113 hours 1compartment NA NA Rat Human +DTXSID8023551 Css NA 0.01645 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023551 Css NA 0.08226 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023551 Css NA 0.0117 mg/L PBTK NA 50% Rat Human +DTXSID8023551 Css NA 0.05492 mg/L PBTK NA 95% Rat Human +DTXSID8023557 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8023557 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8023557 Vd NA 0.7275 L/kg 1compartment NA NA Human Human DTXSID8023557 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8023557 TK.Half.Life NA 4.709 hours 1compartment NA NA Human Human -DTXSID8023557 Css NA 0.8404 mg/L 3compartmentss NA 50% Human Human -DTXSID8023557 Css NA 5.533 mg/L 3compartmentss NA 95% Human Human -DTXSID8023557 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID8023557 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID8023557 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8023557 Css NA 0.4312 mg/L 3compartmentss NA 50% Human Human +DTXSID8023557 Css NA 2.88 mg/L 3compartmentss NA 95% Human Human +DTXSID8023557 Css NA 0.3582 mg/L PBTK NA 50% Human Human +DTXSID8023557 Css NA 1.879 mg/L PBTK NA 95% Human Human +DTXSID8023557 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8023557 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8023557 Vd NA 0.7731 L/kg 1compartment NA NA Rat Human DTXSID8023557 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8023557 TK.Half.Life NA 1.704 hours 1compartment NA NA Rat Human -DTXSID8023557 Css NA 0.2111 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023557 Css NA 1.313 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023557 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID8023557 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID8023630 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023630 Fup NA 0.3893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023630 Vd NA 0.7608 L/kg 1compartment NA NA Human Human +DTXSID8023557 Css NA 0.00206 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023557 Css NA 0.01369 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023557 Css NA 0.001681 mg/L PBTK NA 50% Rat Human +DTXSID8023557 Css NA 0.008524 mg/L PBTK NA 95% Rat Human +DTXSID80235590 Clint 1.89 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80235590 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80235590 Vd NA 1.547 L/kg 1compartment NA NA Human Human +DTXSID80235590 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID80235590 TK.Half.Life NA 15.19 hours 1compartment NA NA Human Human +DTXSID80235590 Css NA 0.5728 mg/L 3compartmentss NA 50% Human Human +DTXSID80235590 Css NA 3.817 mg/L 3compartmentss NA 95% Human Human +DTXSID80235590 Css NA 0.4522 mg/L PBTK NA 50% Human Human +DTXSID80235590 Css NA 2.514 mg/L PBTK NA 95% Human Human +DTXSID80235590 Clint 1.89 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80235590 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80235590 Vd NA 1.544 L/kg 1compartment NA NA Rat Human +DTXSID80235590 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80235590 TK.Half.Life NA 8.367 hours 1compartment NA NA Rat Human +DTXSID80235590 Css NA 0.005048 mg/L 3compartmentss NA 50% Rat Human +DTXSID80235590 Css NA 0.0298 mg/L 3compartmentss NA 95% Rat Human +DTXSID80235590 Css NA 0.00387 mg/L PBTK NA 50% Rat Human +DTXSID80235590 Css NA 0.01881 mg/L PBTK NA 95% Rat Human +DTXSID8023630 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023630 Fup 0.562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023630 Vd NA 0.9435 L/kg 1compartment NA NA Human Human DTXSID8023630 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8023630 TK.Half.Life NA 13.12 hours 1compartment NA NA Human Human -DTXSID8023630 Css NA 1.894 mg/L 3compartmentss NA 50% Human Human -DTXSID8023630 Css NA 7.935 mg/L 3compartmentss NA 95% Human Human -DTXSID8023630 Css NA 1.416 mg/L PBTK NA 50% Human Human -DTXSID8023630 Css NA 5.117 mg/L PBTK NA 95% Human Human -DTXSID8023630 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023630 Fup NA 0.3893 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023630 Vd NA 0.686 L/kg 1compartment NA NA Rat Human +DTXSID8023630 TK.Half.Life NA 11.46 hours 1compartment NA NA Human Human +DTXSID8023630 Css NA 1.321 mg/L 3compartmentss NA 50% Human Human +DTXSID8023630 Css NA 8.557 mg/L 3compartmentss NA 95% Human Human +DTXSID8023630 Css NA 1.062 mg/L PBTK NA 50% Human Human +DTXSID8023630 Css NA 5.482 mg/L PBTK NA 95% Human Human +DTXSID8023630 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023630 Fup 0.562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023630 Vd NA 0.8516 L/kg 1compartment NA NA Rat Human DTXSID8023630 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023630 TK.Half.Life NA 3.921 hours 1compartment NA NA Rat Human -DTXSID8023630 Css NA 0.5218 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023630 Css NA 1.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023630 Css NA 0.371 mg/L PBTK NA 50% Rat Human -DTXSID8023630 Css NA 1.133 mg/L PBTK NA 95% Rat Human +DTXSID8023630 TK.Half.Life NA 3.385 hours 1compartment NA NA Rat Human +DTXSID8023630 Css NA 0.08047 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023630 Css NA 0.5136 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023630 Css NA 0.06424 mg/L PBTK NA 50% Rat Human +DTXSID8023630 Css NA 0.3122 mg/L PBTK NA 95% Rat Human DTXSID8023632 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8023632 Fup NA 0.7133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023632 Vd NA 0.5821 L/kg 1compartment NA NA Human Human +DTXSID8023632 Vd NA 0.62 L/kg 1compartment NA NA Human Human DTXSID8023632 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023632 TK.Half.Life NA 5.279 hours 1compartment NA NA Human Human -DTXSID8023632 Css NA 1.108 mg/L 3compartmentss NA 50% Human Human -DTXSID8023632 Css NA 7.149 mg/L 3compartmentss NA 95% Human Human -DTXSID8023632 Css NA 0.8702 mg/L PBTK NA 50% Human Human -DTXSID8023632 Css NA 4.461 mg/L PBTK NA 95% Human Human +DTXSID8023632 TK.Half.Life NA 5.622 hours 1compartment NA NA Human Human +DTXSID8023632 Css NA 0.9252 mg/L 3compartmentss NA 50% Human Human +DTXSID8023632 Css NA 6.091 mg/L 3compartmentss NA 95% Human Human +DTXSID8023632 Css NA 0.7363 mg/L PBTK NA 50% Human Human +DTXSID8023632 Css NA 3.917 mg/L PBTK NA 95% Human Human DTXSID8023632 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8023632 Fup NA 0.7133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023632 Vd NA 0.6208 L/kg 1compartment NA NA Rat Human +DTXSID8023632 Vd NA 0.6532 L/kg 1compartment NA NA Rat Human DTXSID8023632 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023632 TK.Half.Life NA 1.92 hours 1compartment NA NA Rat Human -DTXSID8023632 Css NA 0.2906 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023632 Css NA 1.768 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023632 Css NA 0.219 mg/L PBTK NA 50% Rat Human -DTXSID8023632 Css NA 1.035 mg/L PBTK NA 95% Rat Human +DTXSID8023632 TK.Half.Life NA 2.02 hours 1compartment NA NA Rat Human +DTXSID8023632 Css NA 0.01784 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023632 Css NA 0.1475 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023632 Css NA 0.01372 mg/L PBTK NA 50% Rat Human +DTXSID8023632 Css NA 0.09254 mg/L PBTK NA 95% Rat Human +DTXSID8023634 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023634 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8023634 Vd NA 0.3982 L/kg 1compartment NA NA Human Human +DTXSID8023634 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8023634 TK.Half.Life NA 3.681 hours 1compartment NA NA Human Human +DTXSID8023634 Css NA 0.6622 mg/L 3compartmentss NA 50% Human Human +DTXSID8023634 Css NA 4.225 mg/L 3compartmentss NA 95% Human Human +DTXSID8023634 Css NA 0.4768 mg/L PBTK NA 50% Human Human +DTXSID8023634 Css NA 2.595 mg/L PBTK NA 95% Human Human +DTXSID8023634 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023634 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8023634 Vd NA 0.4259 L/kg 1compartment NA NA Rat Human +DTXSID8023634 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8023634 TK.Half.Life NA 1.341 hours 1compartment NA NA Rat Human +DTXSID8023634 Css NA 0.00354 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023634 Css NA 0.02201 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023634 Css NA 0.002454 mg/L PBTK NA 50% Rat Human +DTXSID8023634 Css NA 0.01297 mg/L PBTK NA 95% Rat Human DTXSID8023636 Clint 3.98 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8023636 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8023636 Vd NA 12.2 L/kg 1compartment NA NA Human Human -DTXSID8023636 Days.Css NA 518 Days PBTK NA NA Human Human -DTXSID8023636 TK.Half.Life NA 1988 hours 1compartment NA NA Human Human -DTXSID8023636 Css NA 10.17 mg/L 3compartmentss NA 50% Human Human -DTXSID8023636 Css NA 60.66 mg/L 3compartmentss NA 95% Human Human -DTXSID8023636 Css NA 13.9 mg/L PBTK NA 50% Human Human -DTXSID8023636 Css NA 79.04 mg/L PBTK NA 95% Human Human +DTXSID8023636 Vd NA 54.08 L/kg 1compartment NA NA Human Human +DTXSID8023636 Days.Css NA 2410 Days PBTK NA NA Human Human +DTXSID8023636 TK.Half.Life NA 8797 hours 1compartment NA NA Human Human +DTXSID8023636 Css NA 2.254 mg/L 3compartmentss NA 50% Human Human +DTXSID8023636 Css NA 14.21 mg/L 3compartmentss NA 95% Human Human +DTXSID8023636 Css NA 13.42 mg/L PBTK NA 50% Human Human +DTXSID8023636 Css NA 76.2 mg/L PBTK NA 95% Human Human DTXSID8023636 Clint 3.98 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8023636 Fup 0.004 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8023636 Vd NA 9.693 L/kg 1compartment NA NA Rat Human -DTXSID8023636 Days.Css NA 293 Days PBTK NA NA Rat Human -DTXSID8023636 TK.Half.Life NA 296.2 hours 1compartment NA NA Rat Human -DTXSID8023636 Css NA 5.428 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023636 Css NA 23.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023636 Css NA 7.433 mg/L PBTK NA 50% Rat Human -DTXSID8023636 Css NA 32.51 mg/L PBTK NA 95% Rat Human -DTXSID8023638 Clint NA 33.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8023636 Vd NA 45.72 L/kg 1compartment NA NA Rat Human +DTXSID8023636 Days.Css NA 1426 Days PBTK NA NA Rat Human +DTXSID8023636 TK.Half.Life NA 1391 hours 1compartment NA NA Rat Human +DTXSID8023636 Css NA 0.2637 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023636 Css NA 1.302 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023636 Css NA 1.735 mg/L PBTK NA 50% Rat Human +DTXSID8023636 Css NA 8.973 mg/L PBTK NA 95% Rat Human +DTXSID8023638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8023638 Fup 0.0044 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8023638 Vd NA 0.1957 L/kg 1compartment NA NA Human Human +DTXSID8023638 Vd NA 0.1719 L/kg 1compartment NA NA Human Human DTXSID8023638 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023638 TK.Half.Life NA 5.097 hours 1compartment NA NA Human Human -DTXSID8023638 Css NA 4.902 mg/L 3compartmentss NA 50% Human Human -DTXSID8023638 Css NA 47.02 mg/L 3compartmentss NA 95% Human Human -DTXSID8023638 Css NA 2.859 mg/L PBTK NA 50% Human Human -DTXSID8023638 Css NA 27.12 mg/L PBTK NA 95% Human Human -DTXSID8023638 Clint NA 33.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8023638 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human +DTXSID8023638 Css NA 6.526 mg/L 3compartmentss NA 50% Human Human +DTXSID8023638 Css NA 65 mg/L 3compartmentss NA 95% Human Human +DTXSID8023638 Css NA 3.806 mg/L PBTK NA 50% Human Human +DTXSID8023638 Css NA 37.59 mg/L PBTK NA 95% Human Human +DTXSID8023638 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8023638 Fup 0.0044 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8023638 Vd NA 0.1814 L/kg 1compartment NA NA Rat Human +DTXSID8023638 Vd NA 0.1672 L/kg 1compartment NA NA Rat Human DTXSID8023638 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023638 TK.Half.Life NA 3.209 hours 1compartment NA NA Rat Human -DTXSID8023638 Css NA 2.76 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023638 Css NA 21.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023638 Css NA 1.497 mg/L PBTK NA 50% Rat Human -DTXSID8023638 Css NA 11.48 mg/L PBTK NA 95% Rat Human +DTXSID8023638 TK.Half.Life NA 4.542 hours 1compartment NA NA Rat Human +DTXSID8023638 Css NA 0.3257 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023638 Css NA 3.283 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023638 Css NA 0.1794 mg/L PBTK NA 50% Rat Human +DTXSID8023638 Css NA 1.819 mg/L PBTK NA 95% Rat Human DTXSID8023680 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8023680 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8023680 Vd NA 0.855 L/kg 1compartment NA NA Human Human +DTXSID8023680 Vd NA 0.7264 L/kg 1compartment NA NA Human Human DTXSID8023680 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023680 TK.Half.Life NA 5.532 hours 1compartment NA NA Human Human -DTXSID8023680 Css NA 0.8218 mg/L 3compartmentss NA 50% Human Human -DTXSID8023680 Css NA 5.515 mg/L 3compartmentss NA 95% Human Human -DTXSID8023680 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID8023680 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID8023680 TK.Half.Life NA 4.702 hours 1compartment NA NA Human Human +DTXSID8023680 Css NA 0.7098 mg/L 3compartmentss NA 50% Human Human +DTXSID8023680 Css NA 5.063 mg/L 3compartmentss NA 95% Human Human +DTXSID8023680 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID8023680 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID8023680 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8023680 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8023680 Vd NA 0.8996 L/kg 1compartment NA NA Rat Human +DTXSID8023680 Vd NA 0.7918 L/kg 1compartment NA NA Rat Human DTXSID8023680 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023680 TK.Half.Life NA 1.983 hours 1compartment NA NA Rat Human -DTXSID8023680 Css NA 0.2061 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023680 Css NA 1.303 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023680 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID8023680 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID8023688 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8023680 TK.Half.Life NA 1.746 hours 1compartment NA NA Rat Human +DTXSID8023680 Css NA 0.01302 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023680 Css NA 0.1 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023680 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID8023680 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID8023688 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8023688 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8023688 Vd NA 0.8257 L/kg 1compartment NA NA Human Human +DTXSID8023688 Vd NA 0.9247 L/kg 1compartment NA NA Human Human DTXSID8023688 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023688 TK.Half.Life NA 7.487 hours 1compartment NA NA Human Human -DTXSID8023688 Css NA 1.051 mg/L 3compartmentss NA 50% Human Human -DTXSID8023688 Css NA 6.801 mg/L 3compartmentss NA 95% Human Human -DTXSID8023688 Css NA 0.875 mg/L PBTK NA 50% Human Human -DTXSID8023688 Css NA 4.408 mg/L PBTK NA 95% Human Human -DTXSID8023688 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8023688 TK.Half.Life NA 8.459 hours 1compartment NA NA Human Human +DTXSID8023688 Css NA 0.9908 mg/L 3compartmentss NA 50% Human Human +DTXSID8023688 Css NA 6.584 mg/L 3compartmentss NA 95% Human Human +DTXSID8023688 Css NA 0.8521 mg/L PBTK NA 50% Human Human +DTXSID8023688 Css NA 4.276 mg/L PBTK NA 95% Human Human +DTXSID8023688 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8023688 Fup 0.72 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8023688 Vd NA 0.8243 L/kg 1compartment NA NA Rat Human +DTXSID8023688 Vd NA 0.9046 L/kg 1compartment NA NA Rat Human DTXSID8023688 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023688 TK.Half.Life NA 2.529 hours 1compartment NA NA Rat Human -DTXSID8023688 Css NA 0.2713 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023688 Css NA 1.719 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023688 Css NA 0.2186 mg/L PBTK NA 50% Rat Human -DTXSID8023688 Css NA 1.026 mg/L PBTK NA 95% Rat Human -DTXSID8023713 Clint NA 2230 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023713 Fup NA 0.4321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8023713 Vd NA 0.8494 L/kg 1compartment NA NA Human Human +DTXSID8023688 TK.Half.Life NA 2.781 hours 1compartment NA NA Rat Human +DTXSID8023688 Css NA 0.05992 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023688 Css NA 0.3921 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023688 Css NA 0.05122 mg/L PBTK NA 50% Rat Human +DTXSID8023688 Css NA 0.2437 mg/L PBTK NA 95% Rat Human +DTXSID8023713 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023713 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8023713 Vd NA 0.9888 L/kg 1compartment NA NA Human Human DTXSID8023713 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8023713 TK.Half.Life NA 0.5884 hours 1compartment NA NA Human Human -DTXSID8023713 Css NA 0.0004739 mg/L 3compartmentss NA 50% Human Human -DTXSID8023713 Css NA 0.004187 mg/L 3compartmentss NA 95% Human Human -DTXSID8023713 Css NA 0.0003666 mg/L PBTK NA 50% Human Human -DTXSID8023713 Css NA 0.002877 mg/L PBTK NA 95% Human Human -DTXSID8023713 Clint NA 2230 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023713 Fup NA 0.4321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8023713 Vd NA 0.7998 L/kg 1compartment NA NA Rat Human +DTXSID8023713 TK.Half.Life NA 1.82 hours 1compartment NA NA Human Human +DTXSID8023713 Css NA 0.1361 mg/L 3compartmentss NA 50% Human Human +DTXSID8023713 Css NA 1.014 mg/L 3compartmentss NA 95% Human Human +DTXSID8023713 Css NA 0.1091 mg/L PBTK NA 50% Human Human +DTXSID8023713 Css NA 0.688 mg/L PBTK NA 95% Human Human +DTXSID8023713 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023713 Fup 0.457 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8023713 Vd NA 0.9087 L/kg 1compartment NA NA Rat Human DTXSID8023713 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8023713 TK.Half.Life NA 0.2403 hours 1compartment NA NA Rat Human -DTXSID8023713 Css NA 0.000258 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023713 Css NA 0.00188 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023713 Css NA 0.0001934 mg/L PBTK NA 50% Rat Human -DTXSID8023713 Css NA 0.00124 mg/L PBTK NA 95% Rat Human +DTXSID8023713 TK.Half.Life NA 0.9081 hours 1compartment NA NA Rat Human +DTXSID8023713 Css NA 0.0158 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023713 Css NA 0.08744 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023713 Css NA 0.0127 mg/L PBTK NA 50% Rat Human +DTXSID8023713 Css NA 0.05753 mg/L PBTK NA 95% Rat Human DTXSID8023715 Clint 58.41 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8023715 Fup 0.051 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8023715 Vd NA 5.087 L/kg 1compartment NA NA Human Human -DTXSID8023715 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8023715 TK.Half.Life NA 32.53 hours 1compartment NA NA Human Human -DTXSID8023715 Css NA 0.391 mg/L 3compartmentss NA 50% Human Human -DTXSID8023715 Css NA 2.828 mg/L 3compartmentss NA 95% Human Human -DTXSID8023715 Css NA 0.5382 mg/L PBTK NA 50% Human Human -DTXSID8023715 Css NA 3.337 mg/L PBTK NA 95% Human Human +DTXSID8023715 Vd NA 8.092 L/kg 1compartment NA NA Human Human +DTXSID8023715 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8023715 TK.Half.Life NA 46.55 hours 1compartment NA NA Human Human +DTXSID8023715 Css NA 0.2446 mg/L 3compartmentss NA 50% Human Human +DTXSID8023715 Css NA 1.862 mg/L 3compartmentss NA 95% Human Human +DTXSID8023715 Css NA 0.4762 mg/L PBTK NA 50% Human Human +DTXSID8023715 Css NA 2.995 mg/L PBTK NA 95% Human Human DTXSID8023715 Clint 58.41 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID8023715 Fup 0.051 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8023715 Vd NA 4.548 L/kg 1compartment NA NA Rat Human -DTXSID8023715 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8023715 TK.Half.Life NA 5.965 hours 1compartment NA NA Rat Human -DTXSID8023715 Css NA 0.206 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023715 Css NA 1.239 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023715 Css NA 0.2857 mg/L PBTK NA 50% Rat Human -DTXSID8023715 Css NA 1.481 mg/L PBTK NA 95% Rat Human +DTXSID8023715 Vd NA 7.843 L/kg 1compartment NA NA Rat Human +DTXSID8023715 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID8023715 TK.Half.Life NA 9.352 hours 1compartment NA NA Rat Human +DTXSID8023715 Css NA 0.02843 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023715 Css NA 0.1989 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023715 Css NA 0.06048 mg/L PBTK NA 50% Rat Human +DTXSID8023715 Css NA 0.3411 mg/L PBTK NA 95% Rat Human DTXSID8023719 Clint 21.85 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.31.5.580 NA Human Human DTXSID8023719 Fup 0.000941 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Human Human -DTXSID8023719 Vd NA 0.909 L/kg 1compartment NA NA Human Human +DTXSID8023719 Vd NA 0.8689 L/kg 1compartment NA NA Human Human DTXSID8023719 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID8023719 TK.Half.Life NA 66.91 hours 1compartment NA NA Human Human -DTXSID8023719 Css NA 14.26 mg/L 3compartmentss NA 50% Human Human -DTXSID8023719 Css NA 111.9 mg/L 3compartmentss NA 95% Human Human -DTXSID8023719 Css NA 8.17 mg/L PBTK NA 50% Human Human -DTXSID8023719 Css NA 64.32 mg/L PBTK NA 95% Human Human +DTXSID8023719 TK.Half.Life NA 65.89 hours 1compartment NA NA Human Human +DTXSID8023719 Css NA 14.92 mg/L 3compartmentss NA 50% Human Human +DTXSID8023719 Css NA 117.1 mg/L 3compartmentss NA 95% Human Human +DTXSID8023719 Css NA 8.178 mg/L PBTK NA 50% Human Human +DTXSID8023719 Css NA 64.2 mg/L PBTK NA 95% Human Human DTXSID8023719 Clint 891 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8023719 Fup 0.000921 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat -DTXSID8023719 Vd NA 0.6559 L/kg 1compartment NA NA Rat Rat +DTXSID8023719 Vd NA 0.627 L/kg 1compartment NA NA Rat Rat DTXSID8023719 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8023719 TK.Half.Life NA 1.027 hours 1compartment NA NA Rat Rat -DTXSID8023719 Css NA 0.1504 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8023719 Css NA 1.038 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8023719 Css NA 0.07992 mg/L PBTK NA 50% Rat Rat -DTXSID8023719 Css NA 0.5569 mg/L PBTK NA 95% Rat Rat +DTXSID8023719 TK.Half.Life NA 1.011 hours 1compartment NA NA Rat Rat +DTXSID8023719 Css NA 0.04759 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8023719 Css NA 0.3227 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8023719 Css NA 0.02702 mg/L PBTK NA 50% Rat Rat +DTXSID8023719 Css NA 0.1831 mg/L PBTK NA 95% Rat Rat +DTXSID80237650 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80237650 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80237650 Vd NA 1.001 L/kg 1compartment NA NA Human Human +DTXSID80237650 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80237650 TK.Half.Life NA 5.523 hours 1compartment NA NA Human Human +DTXSID80237650 Css NA 0.7162 mg/L 3compartmentss NA 50% Human Human +DTXSID80237650 Css NA 4.898 mg/L 3compartmentss NA 95% Human Human +DTXSID80237650 Css NA 0.4698 mg/L PBTK NA 50% Human Human +DTXSID80237650 Css NA 3.044 mg/L PBTK NA 95% Human Human +DTXSID80237650 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80237650 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80237650 Vd NA 0.7982 L/kg 1compartment NA NA Rat Human +DTXSID80237650 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80237650 TK.Half.Life NA 2.467 hours 1compartment NA NA Rat Human +DTXSID80237650 Css NA 0.08838 mg/L 3compartmentss NA 50% Rat Human +DTXSID80237650 Css NA 0.4398 mg/L 3compartmentss NA 95% Rat Human +DTXSID80237650 Css NA 0.05698 mg/L PBTK NA 50% Rat Human +DTXSID80237650 Css NA 0.2631 mg/L PBTK NA 95% Rat Human DTXSID8023846 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8023846 Fup 0.8684 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8023846 Vd NA 0.6425 L/kg 1compartment NA NA Human Human DTXSID8023846 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8023846 TK.Half.Life NA 4.79 hours 1compartment NA NA Human Human -DTXSID8023846 Css NA 0.9802 mg/L 3compartmentss NA 50% Human Human -DTXSID8023846 Css NA 5.705 mg/L 3compartmentss NA 95% Human Human -DTXSID8023846 Css NA 0.7777 mg/L PBTK NA 50% Human Human -DTXSID8023846 Css NA 3.6 mg/L PBTK NA 95% Human Human +DTXSID8023846 Css NA 0.9362 mg/L 3compartmentss NA 50% Human Human +DTXSID8023846 Css NA 5.272 mg/L 3compartmentss NA 95% Human Human +DTXSID8023846 Css NA 0.7412 mg/L PBTK NA 50% Human Human +DTXSID8023846 Css NA 3.339 mg/L PBTK NA 95% Human Human DTXSID8023846 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8023846 Fup 0.8684 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8023846 Vd NA 0.6703 L/kg 1compartment NA NA Rat Human DTXSID8023846 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8023846 TK.Half.Life NA 1.702 hours 1compartment NA NA Rat Human -DTXSID8023846 Css NA 0.2536 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023846 Css NA 1.429 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023846 Css NA 0.1941 mg/L PBTK NA 50% Rat Human -DTXSID8023846 Css NA 0.8459 mg/L PBTK NA 95% Rat Human +DTXSID8023846 Css NA 0.04757 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023846 Css NA 0.2539 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023846 Css NA 0.03845 mg/L PBTK NA 50% Rat Human +DTXSID8023846 Css NA 0.1564 mg/L PBTK NA 95% Rat Human DTXSID8023848 Clint 84.71 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8023848 Fup 0.1598 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8023848 Vd NA 2.26 L/kg 1compartment NA NA Human Human DTXSID8023848 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8023848 TK.Half.Life NA 2.561 hours 1compartment NA NA Human Human -DTXSID8023848 Css NA 0.06796 mg/L 3compartmentss NA 50% Human Human -DTXSID8023848 Css NA 0.4573 mg/L 3compartmentss NA 95% Human Human -DTXSID8023848 Css NA 0.04764 mg/L PBTK NA 50% Human Human -DTXSID8023848 Css NA 0.3031 mg/L PBTK NA 95% Human Human +DTXSID8023848 Css NA 0.05171 mg/L 3compartmentss NA 50% Human Human +DTXSID8023848 Css NA 0.3361 mg/L 3compartmentss NA 95% Human Human +DTXSID8023848 Css NA 0.04489 mg/L PBTK NA 50% Human Human +DTXSID8023848 Css NA 0.292 mg/L PBTK NA 95% Human Human DTXSID8023848 Clint 59.28 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8023848 Fup 0.1923 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8023848 Vd NA 1.814 L/kg 1compartment NA NA Rat Rat DTXSID8023848 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID8023848 TK.Half.Life NA 0.9405 hours 1compartment NA NA Rat Rat -DTXSID8023848 Css NA 0.04698 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8023848 Css NA 0.2412 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8023848 Css NA 0.03117 mg/L PBTK NA 50% Rat Rat -DTXSID8023848 Css NA 0.1559 mg/L PBTK NA 95% Rat Rat +DTXSID8023848 Css NA 0.007943 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8023848 Css NA 0.04256 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8023848 Css NA 0.007156 mg/L PBTK NA 50% Rat Rat +DTXSID8023848 Css NA 0.03829 mg/L PBTK NA 95% Rat Rat +DTXSID80238485 Clint 23.44 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80238485 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80238485 Vd NA 2.181 L/kg 1compartment NA NA Human Human +DTXSID80238485 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80238485 TK.Half.Life NA 2.578 hours 1compartment NA NA Human Human +DTXSID80238485 Css NA 0.05622 mg/L 3compartmentss NA 50% Human Human +DTXSID80238485 Css NA 0.4517 mg/L 3compartmentss NA 95% Human Human +DTXSID80238485 Css NA 0.0513 mg/L PBTK NA 50% Human Human +DTXSID80238485 Css NA 0.3508 mg/L PBTK NA 95% Human Human +DTXSID80238485 Clint 23.44 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80238485 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80238485 Vd NA 2.172 L/kg 1compartment NA NA Rat Human +DTXSID80238485 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80238485 TK.Half.Life NA 1.404 hours 1compartment NA NA Rat Human +DTXSID80238485 Css NA 0.006952 mg/L 3compartmentss NA 50% Rat Human +DTXSID80238485 Css NA 0.04238 mg/L 3compartmentss NA 95% Rat Human +DTXSID80238485 Css NA 0.006441 mg/L PBTK NA 50% Rat Human +DTXSID80238485 Css NA 0.03352 mg/L PBTK NA 95% Rat Human +DTXSID80238521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80238521 Fup 0.05 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80238521 Vd NA 3.01 L/kg 1compartment NA NA Human Human +DTXSID80238521 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID80238521 TK.Half.Life NA 43.57 hours 1compartment NA NA Human Human +DTXSID80238521 Css NA 1.74 mg/L 3compartmentss NA 50% Human Human +DTXSID80238521 Css NA 11.33 mg/L 3compartmentss NA 95% Human Human +DTXSID80238521 Css NA 1.198 mg/L PBTK NA 50% Human Human +DTXSID80238521 Css NA 7.629 mg/L PBTK NA 95% Human Human +DTXSID80238521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80238521 Fup 0.05 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80238521 Vd NA 2.255 L/kg 1compartment NA NA Rat Human +DTXSID80238521 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID80238521 TK.Half.Life NA 7 hours 1compartment NA NA Rat Human +DTXSID80238521 Css NA 0.223 mg/L 3compartmentss NA 50% Rat Human +DTXSID80238521 Css NA 1.215 mg/L 3compartmentss NA 95% Rat Human +DTXSID80238521 Css NA 0.1524 mg/L PBTK NA 50% Rat Human +DTXSID80238521 Css NA 0.8159 mg/L PBTK NA 95% Rat Human DTXSID8023890 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8023890 Fup 0.456 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8023890 Vd NA 0.363 L/kg 1compartment NA NA Human Human DTXSID8023890 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8023890 TK.Half.Life NA 5.15 hours 1compartment NA NA Human Human -DTXSID8023890 Css NA 0.3478 mg/L 3compartmentss NA 50% Human Human -DTXSID8023890 Css NA 1.337 mg/L 3compartmentss NA 95% Human Human -DTXSID8023890 Css NA 0.2426 mg/L PBTK NA 50% Human Human -DTXSID8023890 Css NA 0.8759 mg/L PBTK NA 95% Human Human +DTXSID8023890 Css NA 0.333 mg/L 3compartmentss NA 50% Human Human +DTXSID8023890 Css NA 1.388 mg/L 3compartmentss NA 95% Human Human +DTXSID8023890 Css NA 0.2316 mg/L PBTK NA 50% Human Human +DTXSID8023890 Css NA 0.9152 mg/L PBTK NA 95% Human Human DTXSID8023890 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8023890 Fup 0.456 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8023890 Vd NA 0.3748 L/kg 1compartment NA NA Rat Human DTXSID8023890 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8023890 TK.Half.Life NA 1.812 hours 1compartment NA NA Rat Human -DTXSID8023890 Css NA 0.1559 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023890 Css NA 0.4308 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023890 Css NA 0.1039 mg/L PBTK NA 50% Rat Human -DTXSID8023890 Css NA 0.2671 mg/L PBTK NA 95% Rat Human +DTXSID8023890 Css NA 0.03469 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023890 Css NA 0.09936 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023890 Css NA 0.02393 mg/L PBTK NA 50% Rat Human +DTXSID8023890 Css NA 0.06337 mg/L PBTK NA 95% Rat Human DTXSID8023892 Clint 5.24 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8023892 Fup 0.06687 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8023892 Vd NA 3.019 L/kg 1compartment NA NA Human Human DTXSID8023892 Days.Css NA 28 Days PBTK NA NA Human Human DTXSID8023892 TK.Half.Life NA 151.2 hours 1compartment NA NA Human Human -DTXSID8023892 Css NA 6.306 mg/L 3compartmentss NA 50% Human Human -DTXSID8023892 Css NA 35.63 mg/L 3compartmentss NA 95% Human Human -DTXSID8023892 Css NA 4.381 mg/L PBTK NA 50% Human Human -DTXSID8023892 Css NA 24.16 mg/L PBTK NA 95% Human Human +DTXSID8023892 Css NA 5.32 mg/L 3compartmentss NA 50% Human Human +DTXSID8023892 Css NA 32.12 mg/L 3compartmentss NA 95% Human Human +DTXSID8023892 Css NA 3.7 mg/L PBTK NA 50% Human Human +DTXSID8023892 Css NA 21.48 mg/L PBTK NA 95% Human Human DTXSID8023892 Clint 5.24 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8023892 Fup 0.06687 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8023892 Vd NA 2.265 L/kg 1compartment NA NA Rat Human DTXSID8023892 Days.Css NA 15 Days PBTK NA NA Rat Human DTXSID8023892 TK.Half.Life NA 22.46 hours 1compartment NA NA Rat Human -DTXSID8023892 Css NA 3.465 mg/L 3compartmentss NA 50% Rat Human -DTXSID8023892 Css NA 15.06 mg/L 3compartmentss NA 95% Rat Human -DTXSID8023892 Css NA 2.292 mg/L PBTK NA 50% Rat Human -DTXSID8023892 Css NA 9.705 mg/L PBTK NA 95% Rat Human +DTXSID8023892 Css NA 0.1941 mg/L 3compartmentss NA 50% Rat Human +DTXSID8023892 Css NA 1.25 mg/L 3compartmentss NA 95% Rat Human +DTXSID8023892 Css NA 0.1304 mg/L PBTK NA 50% Rat Human +DTXSID8023892 Css NA 0.8203 mg/L PBTK NA 95% Rat Human DTXSID8024072 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8024072 Fup 0.301 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8024072 Vd NA 2.4 L/kg 1compartment NA NA Human Human -DTXSID8024072 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID8024072 TK.Half.Life NA 124.7 hours 1compartment NA NA Human Human -DTXSID8024072 Css NA 5.394 mg/L 3compartmentss NA 50% Human Human -DTXSID8024072 Css NA 16.06 mg/L 3compartmentss NA 95% Human Human -DTXSID8024072 Css NA 4.129 mg/L PBTK NA 50% Human Human -DTXSID8024072 Css NA 11.05 mg/L PBTK NA 95% Human Human +DTXSID8024072 Vd NA 1.568 L/kg 1compartment NA NA Human Human +DTXSID8024072 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8024072 TK.Half.Life NA 44.66 hours 1compartment NA NA Human Human +DTXSID8024072 Css NA 2.851 mg/L 3compartmentss NA 50% Human Human +DTXSID8024072 Css NA 8.632 mg/L 3compartmentss NA 95% Human Human +DTXSID8024072 Css NA 2.19 mg/L PBTK NA 50% Human Human +DTXSID8024072 Css NA 5.982 mg/L PBTK NA 95% Human Human DTXSID8024072 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8024072 Fup 0.301 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8024072 Vd NA 1.852 L/kg 1compartment NA NA Rat Human -DTXSID8024072 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID8024072 TK.Half.Life NA 18.16 hours 1compartment NA NA Rat Human -DTXSID8024072 Css NA 1.455 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024072 Css NA 3.479 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024072 Css NA 1.072 mg/L PBTK NA 50% Rat Human -DTXSID8024072 Css NA 2.211 mg/L PBTK NA 95% Rat Human -DTXSID8024101 Clint NA 5.411 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024101 Fup NA 0.0703 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024101 Vd NA 0.2547 L/kg 1compartment NA NA Human Human +DTXSID8024072 Vd NA 1.262 L/kg 1compartment NA NA Rat Human +DTXSID8024072 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8024072 TK.Half.Life NA 9.959 hours 1compartment NA NA Rat Human +DTXSID8024072 Css NA 0.179 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024072 Css NA 0.4533 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024072 Css NA 0.1375 mg/L PBTK NA 50% Rat Human +DTXSID8024072 Css NA 0.2971 mg/L PBTK NA 95% Rat Human +DTXSID8024101 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024101 Fup 0.0959 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024101 Vd NA 0.6197 L/kg 1compartment NA NA Human Human DTXSID8024101 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024101 TK.Half.Life NA 2.545 hours 1compartment NA NA Human Human -DTXSID8024101 Css NA 1.614 mg/L 3compartmentss NA 50% Human Human -DTXSID8024101 Css NA 9.716 mg/L 3compartmentss NA 95% Human Human -DTXSID8024101 Css NA 0.9786 mg/L PBTK NA 50% Human Human -DTXSID8024101 Css NA 5.774 mg/L PBTK NA 95% Human Human -DTXSID8024101 Clint NA 5.411 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024101 Fup NA 0.0703 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024101 Vd NA 0.2513 L/kg 1compartment NA NA Rat Human +DTXSID8024101 TK.Half.Life NA 4.114 hours 1compartment NA NA Human Human +DTXSID8024101 Css NA 0.8354 mg/L 3compartmentss NA 50% Human Human +DTXSID8024101 Css NA 5.884 mg/L 3compartmentss NA 95% Human Human +DTXSID8024101 Css NA 0.5279 mg/L PBTK NA 50% Human Human +DTXSID8024101 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID8024101 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024101 Fup 0.0959 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024101 Vd NA 0.5172 L/kg 1compartment NA NA Rat Human DTXSID8024101 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024101 TK.Half.Life NA 1.54 hours 1compartment NA NA Rat Human -DTXSID8024101 Css NA 0.8407 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024101 Css NA 3.721 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024101 Css NA 0.4794 mg/L PBTK NA 50% Rat Human -DTXSID8024101 Css NA 2.056 mg/L PBTK NA 95% Rat Human +DTXSID8024101 TK.Half.Life NA 2.048 hours 1compartment NA NA Rat Human +DTXSID8024101 Css NA 0.03791 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024101 Css NA 0.2912 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024101 Css NA 0.02321 mg/L PBTK NA 50% Rat Human +DTXSID8024101 Css NA 0.1711 mg/L PBTK NA 95% Rat Human DTXSID8024107 Clint 5.594 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8024107 Fup 0.1378 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8024107 Vd NA 2.188 L/kg 1compartment NA NA Human Human DTXSID8024107 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID8024107 TK.Half.Life NA 18.36 hours 1compartment NA NA Human Human -DTXSID8024107 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human -DTXSID8024107 Css NA 6.375 mg/L 3compartmentss NA 95% Human Human -DTXSID8024107 Css NA 0.7411 mg/L PBTK NA 50% Human Human -DTXSID8024107 Css NA 4.122 mg/L PBTK NA 95% Human Human +DTXSID8024107 Css NA 1.03 mg/L 3compartmentss NA 50% Human Human +DTXSID8024107 Css NA 6.098 mg/L 3compartmentss NA 95% Human Human +DTXSID8024107 Css NA 0.7161 mg/L PBTK NA 50% Human Human +DTXSID8024107 Css NA 3.998 mg/L PBTK NA 95% Human Human DTXSID8024107 Clint 5.594 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID8024107 Fup 0.1378 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID8024107 Vd NA 1.663 L/kg 1compartment NA NA Rat Human DTXSID8024107 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8024107 TK.Half.Life NA 5.386 hours 1compartment NA NA Rat Human -DTXSID8024107 Css NA 0.5534 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024107 Css NA 2.364 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024107 Css NA 0.3687 mg/L PBTK NA 50% Rat Human -DTXSID8024107 Css NA 1.446 mg/L PBTK NA 95% Rat Human +DTXSID8024107 Css NA 0.1261 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024107 Css NA 0.5221 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024107 Css NA 0.08668 mg/L PBTK NA 50% Rat Human +DTXSID8024107 Css NA 0.3353 mg/L PBTK NA 95% Rat Human DTXSID8024109 Clint 14.17 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024109 Fup 0.01882 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024109 Vd NA 1.786 L/kg 1compartment NA NA Human Human DTXSID8024109 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID8024109 TK.Half.Life NA 26.55 hours 1compartment NA NA Human Human -DTXSID8024109 Css NA 2.384 mg/L 3compartmentss NA 50% Human Human -DTXSID8024109 Css NA 19.92 mg/L 3compartmentss NA 95% Human Human -DTXSID8024109 Css NA 1.514 mg/L PBTK NA 50% Human Human -DTXSID8024109 Css NA 12.12 mg/L PBTK NA 95% Human Human +DTXSID8024109 Css NA 2.339 mg/L 3compartmentss NA 50% Human Human +DTXSID8024109 Css NA 19.12 mg/L 3compartmentss NA 95% Human Human +DTXSID8024109 Css NA 1.477 mg/L PBTK NA 50% Human Human +DTXSID8024109 Css NA 11.69 mg/L PBTK NA 95% Human Human DTXSID8024109 Clint 14.17 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024109 Fup 0.01882 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024109 Vd NA 1.325 L/kg 1compartment NA NA Rat Human DTXSID8024109 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID8024109 TK.Half.Life NA 9.235 hours 1compartment NA NA Rat Human -DTXSID8024109 Css NA 1.313 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024109 Css NA 8.814 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024109 Css NA 0.7855 mg/L PBTK NA 50% Rat Human -DTXSID8024109 Css NA 5.039 mg/L PBTK NA 95% Rat Human +DTXSID8024109 Css NA 0.301 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024109 Css NA 1.948 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024109 Css NA 0.1862 mg/L PBTK NA 50% Rat Human +DTXSID8024109 Css NA 1.143 mg/L PBTK NA 95% Rat Human DTXSID8024151 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024151 Fup 0.02956 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024151 Vd NA 1.691 L/kg 1compartment NA NA Human Human -DTXSID8024151 Days.Css NA 110 Days PBTK NA NA Human Human +DTXSID8024151 Days.Css NA 111 Days PBTK NA NA Human Human DTXSID8024151 TK.Half.Life NA 455.1 hours 1compartment NA NA Human Human -DTXSID8024151 Css NA 38.84 mg/L 3compartmentss NA 50% Human Human -DTXSID8024151 Css NA 226.4 mg/L 3compartmentss NA 95% Human Human -DTXSID8024151 Css NA 26.95 mg/L PBTK NA 50% Human Human -DTXSID8024151 Css NA 137.1 mg/L PBTK NA 95% Human Human +DTXSID8024151 Css NA 36.56 mg/L 3compartmentss NA 50% Human Human +DTXSID8024151 Css NA 184.7 mg/L 3compartmentss NA 95% Human Human +DTXSID8024151 Css NA 26.81 mg/L PBTK NA 50% Human Human +DTXSID8024151 Css NA 135.4 mg/L PBTK NA 95% Human Human DTXSID8024151 Clint 46.44 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8024151 Fup 0.04829 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID8024151 Vd NA 1.877 L/kg 1compartment NA NA Rat Rat +DTXSID8024151 Vd 4.4 1.877 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID8024151 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8024151 TK.Half.Life NA 1.929 hours 1compartment NA NA Rat Rat -DTXSID8024151 Css NA 0.1147 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8024151 Css NA 0.7646 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8024151 Css NA 0.07452 mg/L PBTK NA 50% Rat Rat -DTXSID8024151 Css NA 0.4664 mg/L PBTK NA 95% Rat Rat +DTXSID8024151 TK.Half.Life 0.11 1.929 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID8024151 Css 0.0015 0.02281 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID8024151 Css 0.0015 0.145 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID8024151 Css 0.0015 0.01733 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID8024151 Css 0.0015 0.11 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID8024153 Clint NA 37.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8024153 Fup NA 0.0215 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024153 Vd NA 10.56 L/kg 1compartment NA NA Human Human -DTXSID8024153 Days.Css NA 34 Days PBTK NA NA Human Human -DTXSID8024153 TK.Half.Life NA 184.1 hours 1compartment NA NA Human Human -DTXSID8024153 Css NA 1.134 mg/L 3compartmentss NA 50% Human Human -DTXSID8024153 Css NA 6.574 mg/L 3compartmentss NA 95% Human Human -DTXSID8024153 Css NA 1.4 mg/L PBTK NA 50% Human Human -DTXSID8024153 Css NA 7.674 mg/L PBTK NA 95% Human Human +DTXSID8024153 Vd NA 7.837 L/kg 1compartment NA NA Human Human +DTXSID8024153 Days.Css NA 23 Days PBTK NA NA Human Human +DTXSID8024153 TK.Half.Life NA 137.4 hours 1compartment NA NA Human Human +DTXSID8024153 Css NA 1.348 mg/L 3compartmentss NA 50% Human Human +DTXSID8024153 Css NA 7.943 mg/L 3compartmentss NA 95% Human Human +DTXSID8024153 Css NA 1.367 mg/L PBTK NA 50% Human Human +DTXSID8024153 Css NA 7.842 mg/L PBTK NA 95% Human Human DTXSID8024153 Clint NA 37.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8024153 Fup NA 0.0215 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024153 Vd NA 8.334 L/kg 1compartment NA NA Rat Human -DTXSID8024153 Days.Css NA 21 Days PBTK NA NA Rat Human -DTXSID8024153 TK.Half.Life NA 25.79 hours 1compartment NA NA Rat Human -DTXSID8024153 Css NA 0.6121 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024153 Css NA 2.638 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024153 Css NA 0.7603 mg/L PBTK NA 50% Rat Human -DTXSID8024153 Css NA 3.265 mg/L PBTK NA 95% Rat Human -DTXSID8024157 Clint 12.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8024157 Fup 2.92e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8024157 Vd NA 0.3747 L/kg 1compartment NA NA Human Human -DTXSID8024157 Days.Css NA 82 Days PBTK NA NA Human Human -DTXSID8024157 TK.Half.Life NA 328 hours 1compartment NA NA Human Human -DTXSID8024157 Css NA 61.74 mg/L 3compartmentss NA 50% Human Human -DTXSID8024157 Css NA 384.3 mg/L 3compartmentss NA 95% Human Human -DTXSID8024157 Css NA 36.44 mg/L PBTK NA 50% Human Human -DTXSID8024157 Css NA 223.4 mg/L PBTK NA 95% Human Human -DTXSID8024157 Clint 12.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8024157 Fup 2.92e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8024157 Vd NA 0.2862 L/kg 1compartment NA NA Rat Human -DTXSID8024157 Days.Css NA 40 Days PBTK NA NA Rat Human -DTXSID8024157 TK.Half.Life NA 173.4 hours 1compartment NA NA Rat Human -DTXSID8024157 Css NA 44.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024157 Css NA 141.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024157 Css NA 24.26 mg/L PBTK NA 50% Rat Human -DTXSID8024157 Css NA 77.04 mg/L PBTK NA 95% Rat Human +DTXSID8024153 Vd NA 6.105 L/kg 1compartment NA NA Rat Human +DTXSID8024153 Days.Css NA 14 Days PBTK NA NA Rat Human +DTXSID8024153 TK.Half.Life NA 19.16 hours 1compartment NA NA Rat Human +DTXSID8024153 Css NA 0.1707 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024153 Css NA 0.7962 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024153 Css NA 0.1765 mg/L PBTK NA 50% Rat Human +DTXSID8024153 Css NA 0.8172 mg/L PBTK NA 95% Rat Human DTXSID8024159 Clint 17.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8024159 Fup 0.0718 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8024159 Vd NA 2.788 L/kg 1compartment NA NA Human Human DTXSID8024159 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID8024159 TK.Half.Life NA 25.25 hours 1compartment NA NA Human Human -DTXSID8024159 Css NA 1.041 mg/L 3compartmentss NA 50% Human Human -DTXSID8024159 Css NA 5.946 mg/L 3compartmentss NA 95% Human Human -DTXSID8024159 Css NA 0.7254 mg/L PBTK NA 50% Human Human -DTXSID8024159 Css NA 4.021 mg/L PBTK NA 95% Human Human +DTXSID8024159 Css NA 1.008 mg/L 3compartmentss NA 50% Human Human +DTXSID8024159 Css NA 6.081 mg/L 3compartmentss NA 95% Human Human +DTXSID8024159 Css NA 0.6988 mg/L PBTK NA 50% Human Human +DTXSID8024159 Css NA 4.05 mg/L PBTK NA 95% Human Human DTXSID8024159 Clint 17.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8024159 Fup 0.0718 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8024159 Vd NA 2.093 L/kg 1compartment NA NA Rat Human DTXSID8024159 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID8024159 TK.Half.Life NA 5.184 hours 1compartment NA NA Rat Human -DTXSID8024159 Css NA 0.574 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024159 Css NA 2.771 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024159 Css NA 0.3809 mg/L PBTK NA 50% Rat Human -DTXSID8024159 Css NA 1.825 mg/L PBTK NA 95% Rat Human +DTXSID8024159 Css NA 0.1285 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024159 Css NA 0.6509 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024159 Css NA 0.0881 mg/L PBTK NA 50% Rat Human +DTXSID8024159 Css NA 0.4417 mg/L PBTK NA 95% Rat Human DTXSID8024234 Clint 11.09 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024234 Fup 0.1841 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024234 Vd NA 1.476 L/kg 1compartment NA NA Human Human DTXSID8024234 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8024234 TK.Half.Life NA 4.232 hours 1compartment NA NA Human Human -DTXSID8024234 Css NA 0.268 mg/L 3compartmentss NA 50% Human Human -DTXSID8024234 Css NA 1.762 mg/L 3compartmentss NA 95% Human Human -DTXSID8024234 Css NA 0.1902 mg/L PBTK NA 50% Human Human -DTXSID8024234 Css NA 1.187 mg/L PBTK NA 95% Human Human +DTXSID8024234 Css NA 0.2601 mg/L 3compartmentss NA 50% Human Human +DTXSID8024234 Css NA 1.65 mg/L 3compartmentss NA 95% Human Human +DTXSID8024234 Css NA 0.1849 mg/L PBTK NA 50% Human Human +DTXSID8024234 Css NA 1.106 mg/L PBTK NA 95% Human Human DTXSID8024234 Clint 11.09 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024234 Fup 0.1841 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024234 Vd NA 1.16 L/kg 1compartment NA NA Rat Human DTXSID8024234 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8024234 TK.Half.Life NA 1.688 hours 1compartment NA NA Rat Human -DTXSID8024234 Css NA 0.1452 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024234 Css NA 0.683 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024234 Css NA 0.09858 mg/L PBTK NA 50% Rat Human -DTXSID8024234 Css NA 0.4313 mg/L PBTK NA 95% Rat Human -DTXSID8024236 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024236 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024236 Vd NA 204.9 L/kg 1compartment NA NA Human Human -DTXSID8024236 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8024236 TK.Half.Life NA 9763000 hours 1compartment NA NA Human Human -DTXSID8024236 Css NA 135 mg/L 3compartmentss NA 50% Human Human -DTXSID8024236 Css NA 350.8 mg/L 3compartmentss NA 95% Human Human -DTXSID8024236 Css NA 3668 mg/L PBTK NA 50% Human Human -DTXSID8024236 Css NA 7840 mg/L PBTK NA 95% Human Human -DTXSID8024236 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024236 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024236 Vd NA 181.1 L/kg 1compartment NA NA Rat Human -DTXSID8024236 Days.Css NA 16400 Days PBTK NA NA Rat Human -DTXSID8024236 TK.Half.Life NA 719800 hours 1compartment NA NA Rat Human -DTXSID8024236 Css NA 32.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024236 Css NA 58.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024236 Css NA 983.2 mg/L PBTK NA 50% Rat Human -DTXSID8024236 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID8024234 Css NA 0.03262 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024234 Css NA 0.1507 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024234 Css NA 0.02302 mg/L PBTK NA 50% Rat Human +DTXSID8024234 Css NA 0.09831 mg/L PBTK NA 95% Rat Human DTXSID8024238 Clint 20.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024238 Fup 0.004802 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024238 Vd NA 0.2158 L/kg 1compartment NA NA Human Human DTXSID8024238 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8024238 TK.Half.Life NA 8.174 hours 1compartment NA NA Human Human -DTXSID8024238 Css NA 7.157 mg/L 3compartmentss NA 50% Human Human -DTXSID8024238 Css NA 68.35 mg/L 3compartmentss NA 95% Human Human -DTXSID8024238 Css NA 4.184 mg/L PBTK NA 50% Human Human -DTXSID8024238 Css NA 40 mg/L PBTK NA 95% Human Human +DTXSID8024238 Css NA 6.148 mg/L 3compartmentss NA 50% Human Human +DTXSID8024238 Css NA 59.24 mg/L 3compartmentss NA 95% Human Human +DTXSID8024238 Css NA 3.619 mg/L PBTK NA 50% Human Human +DTXSID8024238 Css NA 33.97 mg/L PBTK NA 95% Human Human DTXSID8024238 Clint 20.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024238 Fup 0.004802 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024238 Vd NA 0.1945 L/kg 1compartment NA NA Rat Human DTXSID8024238 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8024238 TK.Half.Life NA 4.969 hours 1compartment NA NA Rat Human -DTXSID8024238 Css NA 4.082 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024238 Css NA 30.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024238 Css NA 2.22 mg/L PBTK NA 50% Rat Human -DTXSID8024238 Css NA 16.57 mg/L PBTK NA 95% Rat Human +DTXSID8024238 Css NA 0.3012 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024238 Css NA 3.291 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024238 Css NA 0.1675 mg/L PBTK NA 50% Rat Human +DTXSID8024238 Css NA 1.838 mg/L PBTK NA 95% Rat Human DTXSID8024280 Clint 17 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8024280 Fup 0.0508 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8024280 Vd NA 2.433 L/kg 1compartment NA NA Human Human DTXSID8024280 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID8024280 TK.Half.Life NA 20.18 hours 1compartment NA NA Human Human -DTXSID8024280 Css NA 0.9854 mg/L 3compartmentss NA 50% Human Human -DTXSID8024280 Css NA 6.072 mg/L 3compartmentss NA 95% Human Human -DTXSID8024280 Css NA 0.6692 mg/L PBTK NA 50% Human Human -DTXSID8024280 Css NA 4.052 mg/L PBTK NA 95% Human Human +DTXSID8024280 Css NA 0.9635 mg/L 3compartmentss NA 50% Human Human +DTXSID8024280 Css NA 6.082 mg/L 3compartmentss NA 95% Human Human +DTXSID8024280 Css NA 0.6564 mg/L PBTK NA 50% Human Human +DTXSID8024280 Css NA 3.948 mg/L PBTK NA 95% Human Human DTXSID8024280 Clint 17 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8024280 Fup 0.0508 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8024280 Vd NA 1.822 L/kg 1compartment NA NA Rat Human -DTXSID8024280 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8024280 TK.Half.Life NA 5.279 hours 1compartment NA NA Rat Human -DTXSID8024280 Css NA 0.5428 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024280 Css NA 2.706 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024280 Css NA 0.3498 mg/L PBTK NA 50% Rat Human -DTXSID8024280 Css NA 1.711 mg/L PBTK NA 95% Rat Human -DTXSID8024284 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024284 Fup NA 0.9077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024284 Vd NA 0.8288 L/kg 1compartment NA NA Human Human -DTXSID8024284 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024284 TK.Half.Life NA 5.924 hours 1compartment NA NA Human Human -DTXSID8024284 Css NA 0.9046 mg/L 3compartmentss NA 50% Human Human -DTXSID8024284 Css NA 5.188 mg/L 3compartmentss NA 95% Human Human -DTXSID8024284 Css NA 0.765 mg/L PBTK NA 50% Human Human -DTXSID8024284 Css NA 3.394 mg/L PBTK NA 95% Human Human -DTXSID8024284 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024284 Fup NA 0.9077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024284 Vd NA 0.8504 L/kg 1compartment NA NA Rat Human +DTXSID8024280 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8024280 TK.Half.Life NA 1.017 hours 1compartment NA NA Rat Human +DTXSID8024280 Css NA 0.009155 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024280 Css NA 0.06014 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024280 Css NA 0.006113 mg/L PBTK NA 50% Rat Human +DTXSID8024280 Css NA 0.03913 mg/L PBTK NA 95% Rat Human +DTXSID8024284 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024284 Fup 0.308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024284 Vd NA 0.4837 L/kg 1compartment NA NA Human Human +DTXSID8024284 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8024284 TK.Half.Life NA 10.19 hours 1compartment NA NA Human Human +DTXSID8024284 Css NA 2.091 mg/L 3compartmentss NA 50% Human Human +DTXSID8024284 Css NA 8.502 mg/L 3compartmentss NA 95% Human Human +DTXSID8024284 Css NA 1.469 mg/L PBTK NA 50% Human Human +DTXSID8024284 Css NA 5.296 mg/L PBTK NA 95% Human Human +DTXSID8024284 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024284 Fup 0.308 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024284 Vd NA 0.4853 L/kg 1compartment NA NA Rat Human DTXSID8024284 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024284 TK.Half.Life NA 2.067 hours 1compartment NA NA Rat Human -DTXSID8024284 Css NA 0.2313 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024284 Css NA 1.301 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024284 Css NA 0.1902 mg/L PBTK NA 50% Rat Human -DTXSID8024284 Css NA 0.7909 mg/L PBTK NA 95% Rat Human +DTXSID8024284 TK.Half.Life NA 3.476 hours 1compartment NA NA Rat Human +DTXSID8024284 Css NA 0.03769 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024284 Css NA 0.2294 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024284 Css NA 0.02533 mg/L PBTK NA 50% Rat Human +DTXSID8024284 Css NA 0.142 mg/L PBTK NA 95% Rat Human DTXSID8024286 Clint NA 0.05139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8024286 Fup NA 0.6095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024286 Vd NA 1.663 L/kg 1compartment NA NA Human Human +DTXSID8024286 Vd NA 1.787 L/kg 1compartment NA NA Human Human DTXSID8024286 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8024286 TK.Half.Life NA 16.29 hours 1compartment NA NA Human Human -DTXSID8024286 Css NA 0.9412 mg/L 3compartmentss NA 50% Human Human -DTXSID8024286 Css NA 7.103 mg/L 3compartmentss NA 95% Human Human -DTXSID8024286 Css NA 0.8832 mg/L PBTK NA 50% Human Human -DTXSID8024286 Css NA 4.694 mg/L PBTK NA 95% Human Human +DTXSID8024286 TK.Half.Life NA 17.51 hours 1compartment NA NA Human Human +DTXSID8024286 Css NA 0.7817 mg/L 3compartmentss NA 50% Human Human +DTXSID8024286 Css NA 6.169 mg/L 3compartmentss NA 95% Human Human +DTXSID8024286 Css NA 0.7503 mg/L PBTK NA 50% Human Human +DTXSID8024286 Css NA 4.078 mg/L PBTK NA 95% Human Human DTXSID8024286 Clint NA 0.05139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8024286 Fup NA 0.6095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024286 Vd NA 1.684 L/kg 1compartment NA NA Rat Human +DTXSID8024286 Vd NA 1.808 L/kg 1compartment NA NA Rat Human DTXSID8024286 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024286 TK.Half.Life NA 5.849 hours 1compartment NA NA Rat Human -DTXSID8024286 Css NA 0.256 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024286 Css NA 1.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024286 Css NA 0.2348 mg/L PBTK NA 50% Rat Human -DTXSID8024286 Css NA 1.174 mg/L PBTK NA 95% Rat Human +DTXSID8024286 TK.Half.Life NA 6.284 hours 1compartment NA NA Rat Human +DTXSID8024286 Css NA 0.01557 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024286 Css NA 0.1517 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024286 Css NA 0.01469 mg/L PBTK NA 50% Rat Human +DTXSID8024286 Css NA 0.1051 mg/L PBTK NA 95% Rat Human DTXSID8024311 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8024311 Fup NA 0.3424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024311 Vd NA 0.4241 L/kg 1compartment NA NA Human Human +DTXSID8024311 Vd NA 0.4206 L/kg 1compartment NA NA Human Human DTXSID8024311 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024311 TK.Half.Life NA 8.014 hours 1compartment NA NA Human Human -DTXSID8024311 Css NA 2.217 mg/L 3compartmentss NA 50% Human Human -DTXSID8024311 Css NA 8.864 mg/L 3compartmentss NA 95% Human Human -DTXSID8024311 Css NA 1.561 mg/L PBTK NA 50% Human Human -DTXSID8024311 Css NA 5.526 mg/L PBTK NA 95% Human Human +DTXSID8024311 TK.Half.Life NA 7.948 hours 1compartment NA NA Human Human +DTXSID8024311 Css NA 1.858 mg/L 3compartmentss NA 50% Human Human +DTXSID8024311 Css NA 7.583 mg/L 3compartmentss NA 95% Human Human +DTXSID8024311 Css NA 1.304 mg/L PBTK NA 50% Human Human +DTXSID8024311 Css NA 4.737 mg/L PBTK NA 95% Human Human DTXSID8024311 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8024311 Fup NA 0.3424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024311 Vd NA 0.4369 L/kg 1compartment NA NA Rat Human +DTXSID8024311 Vd NA 0.4335 L/kg 1compartment NA NA Rat Human DTXSID8024311 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024311 TK.Half.Life NA 2.814 hours 1compartment NA NA Rat Human -DTXSID8024311 Css NA 0.6071 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024311 Css NA 2.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024311 Css NA 0.405 mg/L PBTK NA 50% Rat Human -DTXSID8024311 Css NA 1.223 mg/L PBTK NA 95% Rat Human +DTXSID8024311 TK.Half.Life NA 2.793 hours 1compartment NA NA Rat Human +DTXSID8024311 Css NA 0.03334 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024311 Css NA 0.2123 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024311 Css NA 0.02252 mg/L PBTK NA 50% Rat Human +DTXSID8024311 Css NA 0.1325 mg/L PBTK NA 95% Rat Human DTXSID8024315 Clint 16.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024315 Fup 0.08429 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024315 Vd NA 1.693 L/kg 1compartment NA NA Human Human DTXSID8024315 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8024315 TK.Half.Life NA 7.048 hours 1compartment NA NA Human Human -DTXSID8024315 Css NA 0.5262 mg/L 3compartmentss NA 50% Human Human -DTXSID8024315 Css NA 3.757 mg/L 3compartmentss NA 95% Human Human -DTXSID8024315 Css NA 0.3478 mg/L PBTK NA 50% Human Human -DTXSID8024315 Css NA 2.378 mg/L PBTK NA 95% Human Human +DTXSID8024315 Css NA 0.5114 mg/L 3compartmentss NA 50% Human Human +DTXSID8024315 Css NA 3.687 mg/L 3compartmentss NA 95% Human Human +DTXSID8024315 Css NA 0.3378 mg/L PBTK NA 50% Human Human +DTXSID8024315 Css NA 2.302 mg/L PBTK NA 95% Human Human DTXSID8024315 Clint 16.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024315 Fup 0.08429 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024315 Vd NA 1.284 L/kg 1compartment NA NA Rat Human DTXSID8024315 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024315 TK.Half.Life NA 2.585 hours 1compartment NA NA Rat Human -DTXSID8024315 Css NA 0.2922 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024315 Css NA 1.613 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024315 Css NA 0.1819 mg/L PBTK NA 50% Rat Human -DTXSID8024315 Css NA 0.9593 mg/L PBTK NA 95% Rat Human +DTXSID8024315 TK.Half.Life NA 0.8708 hours 1compartment NA NA Rat Human +DTXSID8024315 Css NA 0.01229 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024315 Css NA 0.08138 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024315 Css NA 0.007963 mg/L PBTK NA 50% Rat Human +DTXSID8024315 Css NA 0.051 mg/L PBTK NA 95% Rat Human DTXSID8024317 Clint 2.272 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024317 Fup 0.1029 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8024317 Vd NA 0.7047 L/kg 1compartment NA NA Human Human DTXSID8024317 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8024317 TK.Half.Life NA 9.764 hours 1compartment NA NA Human Human -DTXSID8024317 Css NA 2.123 mg/L 3compartmentss NA 50% Human Human -DTXSID8024317 Css NA 12.37 mg/L 3compartmentss NA 95% Human Human -DTXSID8024317 Css NA 1.354 mg/L PBTK NA 50% Human Human -DTXSID8024317 Css NA 7.477 mg/L PBTK NA 95% Human Human +DTXSID8024317 Css NA 2.063 mg/L 3compartmentss NA 50% Human Human +DTXSID8024317 Css NA 12.16 mg/L 3compartmentss NA 95% Human Human +DTXSID8024317 Css NA 1.32 mg/L PBTK NA 50% Human Human +DTXSID8024317 Css NA 7.355 mg/L PBTK NA 95% Human Human DTXSID8024317 Clint 2.272 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024317 Fup 0.1029 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8024317 Vd NA 0.5797 L/kg 1compartment NA NA Rat Human DTXSID8024317 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8024317 TK.Half.Life NA 4.376 hours 1compartment NA NA Rat Human -DTXSID8024317 Css NA 1.007 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024317 Css NA 4.446 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024317 Css NA 0.6049 mg/L PBTK NA 50% Rat Human -DTXSID8024317 Css NA 2.487 mg/L PBTK NA 95% Rat Human -DTXSID8024498 Clint NA 0.6529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024498 Fup NA 0.9125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024498 Vd NA 1.093 L/kg 1compartment NA NA Human Human +DTXSID8024317 Css NA 0.2256 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024317 Css NA 1.009 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024317 Css NA 0.1405 mg/L PBTK NA 50% Rat Human +DTXSID8024317 Css NA 0.5845 mg/L PBTK NA 95% Rat Human +DTXSID8024498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024498 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024498 Vd NA 0.7555 L/kg 1compartment NA NA Human Human DTXSID8024498 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024498 TK.Half.Life NA 3.974 hours 1compartment NA NA Human Human -DTXSID8024498 Css NA 0.3919 mg/L 3compartmentss NA 50% Human Human -DTXSID8024498 Css NA 1.677 mg/L 3compartmentss NA 95% Human Human -DTXSID8024498 Css NA 0.35 mg/L PBTK NA 50% Human Human -DTXSID8024498 Css NA 1.222 mg/L PBTK NA 95% Human Human -DTXSID8024498 Clint NA 0.6529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024498 Fup NA 0.9125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024498 Vd NA 1.063 L/kg 1compartment NA NA Rat Human +DTXSID8024498 TK.Half.Life NA 0.7533 hours 1compartment NA NA Human Human +DTXSID8024498 Css NA 0.03865 mg/L 3compartmentss NA 50% Human Human +DTXSID8024498 Css NA 0.3541 mg/L 3compartmentss NA 95% Human Human +DTXSID8024498 Css NA 0.03018 mg/L PBTK NA 50% Human Human +DTXSID8024498 Css NA 0.244 mg/L PBTK NA 95% Human Human +DTXSID8024498 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024498 Fup 0.495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024498 Vd NA 0.7317 L/kg 1compartment NA NA Rat Human DTXSID8024498 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024498 TK.Half.Life NA 1.722 hours 1compartment NA NA Rat Human -DTXSID8024498 Css NA 0.1384 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024498 Css NA 0.5064 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024498 Css NA 0.1225 mg/L PBTK NA 50% Rat Human -DTXSID8024498 Css NA 0.3415 mg/L PBTK NA 95% Rat Human +DTXSID8024498 TK.Half.Life NA 0.3681 hours 1compartment NA NA Rat Human +DTXSID8024498 Css NA 0.004818 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024498 Css NA 0.03476 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024498 Css NA 0.003754 mg/L PBTK NA 50% Rat Human +DTXSID8024498 Css NA 0.02299 mg/L PBTK NA 95% Rat Human DTXSID8024523 Clint 25.92 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8024523 Fup 0.1744 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8024523 Vd NA 1.939 L/kg 1compartment NA NA Human Human DTXSID8024523 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8024523 TK.Half.Life NA 3.819 hours 1compartment NA NA Human Human -DTXSID8024523 Css NA 0.1507 mg/L 3compartmentss NA 50% Human Human -DTXSID8024523 Css NA 0.9855 mg/L 3compartmentss NA 95% Human Human -DTXSID8024523 Css NA 0.1077 mg/L PBTK NA 50% Human Human -DTXSID8024523 Css NA 0.6748 mg/L PBTK NA 95% Human Human +DTXSID8024523 Css NA 0.1458 mg/L 3compartmentss NA 50% Human Human +DTXSID8024523 Css NA 0.9447 mg/L 3compartmentss NA 95% Human Human +DTXSID8024523 Css NA 0.104 mg/L PBTK NA 50% Human Human +DTXSID8024523 Css NA 0.6355 mg/L PBTK NA 95% Human Human DTXSID8024523 Clint 25.92 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID8024523 Fup 0.1744 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID8024523 Vd NA 1.492 L/kg 1compartment NA NA Rat Human DTXSID8024523 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8024523 TK.Half.Life NA 1.321 hours 1compartment NA NA Rat Human -DTXSID8024523 Css NA 0.08236 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024523 Css NA 0.4135 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024523 Css NA 0.05652 mg/L PBTK NA 50% Rat Human -DTXSID8024523 Css NA 0.2727 mg/L PBTK NA 95% Rat Human -DTXSID8024529 Clint NA 21.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024529 Fup NA 0.737 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024529 Vd NA 1.105 L/kg 1compartment NA NA Human Human +DTXSID8024523 Css NA 0.01831 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024523 Css NA 0.09858 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024523 Css NA 0.01297 mg/L PBTK NA 50% Rat Human +DTXSID8024523 Css NA 0.06781 mg/L PBTK NA 95% Rat Human +DTXSID8024529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024529 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024529 Vd NA 0.8855 L/kg 1compartment NA NA Human Human DTXSID8024529 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024529 TK.Half.Life NA 0.8722 hours 1compartment NA NA Human Human -DTXSID8024529 Css NA 0.02905 mg/L 3compartmentss NA 50% Human Human -DTXSID8024529 Css NA 0.2811 mg/L 3compartmentss NA 95% Human Human -DTXSID8024529 Css NA 0.02508 mg/L PBTK NA 50% Human Human -DTXSID8024529 Css NA 0.2094 mg/L PBTK NA 95% Human Human -DTXSID8024529 Clint NA 21.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024529 Fup NA 0.737 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024529 Vd NA 1.041 L/kg 1compartment NA NA Rat Human +DTXSID8024529 TK.Half.Life NA 0.8637 hours 1compartment NA NA Human Human +DTXSID8024529 Css NA 0.03708 mg/L 3compartmentss NA 50% Human Human +DTXSID8024529 Css NA 0.3423 mg/L 3compartmentss NA 95% Human Human +DTXSID8024529 Css NA 0.02958 mg/L PBTK NA 50% Human Human +DTXSID8024529 Css NA 0.2382 mg/L PBTK NA 95% Human Human +DTXSID8024529 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024529 Fup 0.508 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024529 Vd NA 0.8316 L/kg 1compartment NA NA Rat Human DTXSID8024529 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024529 TK.Half.Life NA 0.399 hours 1compartment NA NA Rat Human -DTXSID8024529 Css NA 0.0145 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024529 Css NA 0.1316 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024529 Css NA 0.01231 mg/L PBTK NA 50% Rat Human -DTXSID8024529 Css NA 0.08904 mg/L PBTK NA 95% Rat Human -DTXSID8024573 Clint NA 1.177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024573 Fup NA 0.517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024573 Vd NA 1.139 L/kg 1compartment NA NA Human Human +DTXSID8024529 TK.Half.Life NA 0.407 hours 1compartment NA NA Rat Human +DTXSID8024529 Css NA 0.004606 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024529 Css NA 0.03455 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024529 Css NA 0.003693 mg/L PBTK NA 50% Rat Human +DTXSID8024529 Css NA 0.02299 mg/L PBTK NA 95% Rat Human +DTXSID8024573 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024573 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024573 Vd NA 0.9098 L/kg 1compartment NA NA Human Human DTXSID8024573 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024573 TK.Half.Life NA 5.441 hours 1compartment NA NA Human Human -DTXSID8024573 Css NA 0.4692 mg/L 3compartmentss NA 50% Human Human -DTXSID8024573 Css NA 2.846 mg/L 3compartmentss NA 95% Human Human -DTXSID8024573 Css NA 0.3905 mg/L PBTK NA 50% Human Human -DTXSID8024573 Css NA 1.894 mg/L PBTK NA 95% Human Human -DTXSID8024573 Clint NA 1.177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024573 Fup NA 0.517 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024573 Vd NA 1.025 L/kg 1compartment NA NA Rat Human +DTXSID8024573 TK.Half.Life NA 1.086 hours 1compartment NA NA Human Human +DTXSID8024573 Css NA 0.05653 mg/L 3compartmentss NA 50% Human Human +DTXSID8024573 Css NA 0.4327 mg/L 3compartmentss NA 95% Human Human +DTXSID8024573 Css NA 0.0424 mg/L PBTK NA 50% Human Human +DTXSID8024573 Css NA 0.2985 mg/L PBTK NA 95% Human Human +DTXSID8024573 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024573 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024573 Vd NA 0.8157 L/kg 1compartment NA NA Rat Human DTXSID8024573 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024573 TK.Half.Life NA 2.328 hours 1compartment NA NA Rat Human -DTXSID8024573 Css NA 0.1928 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024573 Css NA 1.005 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024573 Css NA 0.1552 mg/L PBTK NA 50% Rat Human -DTXSID8024573 Css NA 0.6129 mg/L PBTK NA 95% Rat Human -DTXSID8024602 Clint NA 1255 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024602 Fup NA 0.987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024602 Vd NA 6.756 L/kg 1compartment NA NA Human Human -DTXSID8024602 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024602 TK.Half.Life NA 2.154 hours 1compartment NA NA Human Human -DTXSID8024602 Css NA 0.0003324 mg/L 3compartmentss NA 50% Human Human -DTXSID8024602 Css NA 0.002674 mg/L 3compartmentss NA 95% Human Human -DTXSID8024602 Css NA 0.0005478 mg/L PBTK NA 50% Human Human -DTXSID8024602 Css NA 0.003756 mg/L PBTK NA 95% Human Human -DTXSID8024602 Clint NA 1255 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024602 Fup NA 0.987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024602 Vd NA 6.564 L/kg 1compartment NA NA Rat Human +DTXSID8024573 TK.Half.Life NA 0.5026 hours 1compartment NA NA Rat Human +DTXSID8024573 Css NA 0.006969 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024573 Css NA 0.04305 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024573 Css NA 0.00525 mg/L PBTK NA 50% Rat Human +DTXSID8024573 Css NA 0.02916 mg/L PBTK NA 95% Rat Human +DTXSID8024602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024602 Fup 0.0809 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024602 Vd NA 1.47 L/kg 1compartment NA NA Human Human +DTXSID8024602 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8024602 TK.Half.Life NA 13.01 hours 1compartment NA NA Human Human +DTXSID8024602 Css NA 1.258 mg/L 3compartmentss NA 50% Human Human +DTXSID8024602 Css NA 7.995 mg/L 3compartmentss NA 95% Human Human +DTXSID8024602 Css NA 0.8184 mg/L PBTK NA 50% Human Human +DTXSID8024602 Css NA 4.94 mg/L PBTK NA 95% Human Human +DTXSID8024602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024602 Fup 0.0809 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024602 Vd NA 1.119 L/kg 1compartment NA NA Rat Human DTXSID8024602 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024602 TK.Half.Life NA 0.8916 hours 1compartment NA NA Rat Human -DTXSID8024602 Css NA 0.0001707 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024602 Css NA 0.00123 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024602 Css NA 0.0002901 mg/L PBTK NA 50% Rat Human -DTXSID8024602 Css NA 0.001744 mg/L PBTK NA 95% Rat Human +DTXSID8024602 TK.Half.Life NA 5.001 hours 1compartment NA NA Rat Human +DTXSID8024602 Css NA 0.1534 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024602 Css NA 0.7246 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024602 Css NA 0.09806 mg/L PBTK NA 50% Rat Human +DTXSID8024602 Css NA 0.433 mg/L PBTK NA 95% Rat Human DTXSID8024608 Clint NA 371.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8024608 Fup NA 0.0063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024608 Vd NA 2.942 L/kg 1compartment NA NA Human Human +DTXSID8024608 Vd NA 3.007 L/kg 1compartment NA NA Human Human DTXSID8024608 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024608 TK.Half.Life NA 6.769 hours 1compartment NA NA Human Human -DTXSID8024608 Css NA 0.2013 mg/L 3compartmentss NA 50% Human Human -DTXSID8024608 Css NA 1.314 mg/L 3compartmentss NA 95% Human Human -DTXSID8024608 Css NA 0.1368 mg/L PBTK NA 50% Human Human -DTXSID8024608 Css NA 0.8609 mg/L PBTK NA 95% Human Human +DTXSID8024608 TK.Half.Life NA 7.17 hours 1compartment NA NA Human Human +DTXSID8024608 Css NA 0.1721 mg/L 3compartmentss NA 50% Human Human +DTXSID8024608 Css NA 1.236 mg/L 3compartmentss NA 95% Human Human +DTXSID8024608 Css NA 0.1174 mg/L PBTK NA 50% Human Human +DTXSID8024608 Css NA 0.8294 mg/L PBTK NA 95% Human Human DTXSID8024608 Clint NA 371.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8024608 Fup NA 0.0063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024608 Vd NA 2.2 L/kg 1compartment NA NA Rat Human +DTXSID8024608 Vd NA 2.25 L/kg 1compartment NA NA Rat Human DTXSID8024608 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024608 TK.Half.Life NA 1.504 hours 1compartment NA NA Rat Human -DTXSID8024608 Css NA 0.1133 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024608 Css NA 0.6323 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024608 Css NA 0.07339 mg/L PBTK NA 50% Rat Human -DTXSID8024608 Css NA 0.3999 mg/L PBTK NA 95% Rat Human -DTXSID8024652 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024652 Fup NA 0.9048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024652 Vd NA 0.5682 L/kg 1compartment NA NA Human Human +DTXSID8024608 TK.Half.Life NA 1.52 hours 1compartment NA NA Rat Human +DTXSID8024608 Css NA 0.008857 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024608 Css NA 0.06125 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024608 Css NA 0.005948 mg/L PBTK NA 50% Rat Human +DTXSID8024608 Css NA 0.03915 mg/L PBTK NA 95% Rat Human +DTXSID8024652 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024652 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024652 Vd NA 0.5458 L/kg 1compartment NA NA Human Human DTXSID8024652 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024652 TK.Half.Life NA 4.065 hours 1compartment NA NA Human Human -DTXSID8024652 Css NA 0.9508 mg/L 3compartmentss NA 50% Human Human -DTXSID8024652 Css NA 3.494 mg/L 3compartmentss NA 95% Human Human -DTXSID8024652 Css NA 0.7308 mg/L PBTK NA 50% Human Human -DTXSID8024652 Css NA 2.294 mg/L PBTK NA 95% Human Human -DTXSID8024652 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024652 Fup NA 0.9048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024652 Vd NA 0.5889 L/kg 1compartment NA NA Rat Human +DTXSID8024652 TK.Half.Life NA 5.089 hours 1compartment NA NA Human Human +DTXSID8024652 Css NA 1.145 mg/L 3compartmentss NA 50% Human Human +DTXSID8024652 Css NA 7.14 mg/L 3compartmentss NA 95% Human Human +DTXSID8024652 Css NA 0.8672 mg/L PBTK NA 50% Human Human +DTXSID8024652 Css NA 4.438 mg/L PBTK NA 95% Human Human +DTXSID8024652 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024652 Fup 0.695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024652 Vd NA 0.5549 L/kg 1compartment NA NA Rat Human DTXSID8024652 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024652 TK.Half.Life NA 1.435 hours 1compartment NA NA Rat Human -DTXSID8024652 Css NA 0.2485 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024652 Css NA 0.8436 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024652 Css NA 0.185 mg/L PBTK NA 50% Rat Human -DTXSID8024652 Css NA 0.5172 mg/L PBTK NA 95% Rat Human -DTXSID8024733 Clint NA 26.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024733 Fup NA 0.2508 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024733 Vd NA 1.84 L/kg 1compartment NA NA Human Human +DTXSID8024652 TK.Half.Life NA 1.761 hours 1compartment NA NA Rat Human +DTXSID8024652 Css NA 0.06862 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024652 Css NA 0.4097 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024652 Css NA 0.05166 mg/L PBTK NA 50% Rat Human +DTXSID8024652 Css NA 0.2459 mg/L PBTK NA 95% Rat Human +DTXSID8024733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024733 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024733 Vd NA 1.879 L/kg 1compartment NA NA Human Human DTXSID8024733 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024733 TK.Half.Life NA 2.611 hours 1compartment NA NA Human Human -DTXSID8024733 Css NA 0.0853 mg/L 3compartmentss NA 50% Human Human -DTXSID8024733 Css NA 0.5605 mg/L 3compartmentss NA 95% Human Human -DTXSID8024733 Css NA 0.06491 mg/L PBTK NA 50% Human Human -DTXSID8024733 Css NA 0.3991 mg/L PBTK NA 95% Human Human -DTXSID8024733 Clint NA 26.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024733 Fup NA 0.2508 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024733 Vd NA 1.506 L/kg 1compartment NA NA Rat Human +DTXSID8024733 TK.Half.Life NA 2.179 hours 1compartment NA NA Human Human +DTXSID8024733 Css NA 0.05504 mg/L 3compartmentss NA 50% Human Human +DTXSID8024733 Css NA 0.4277 mg/L 3compartmentss NA 95% Human Human +DTXSID8024733 Css NA 0.04552 mg/L PBTK NA 50% Human Human +DTXSID8024733 Css NA 0.3182 mg/L PBTK NA 95% Human Human +DTXSID8024733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024733 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024733 Vd NA 1.595 L/kg 1compartment NA NA Rat Human DTXSID8024733 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024733 TK.Half.Life NA 1.017 hours 1compartment NA NA Rat Human -DTXSID8024733 Css NA 0.04584 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024733 Css NA 0.2468 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024733 Css NA 0.03387 mg/L PBTK NA 50% Rat Human -DTXSID8024733 Css NA 0.1695 mg/L PBTK NA 95% Rat Human -DTXSID8024787 Clint NA 0.8923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024787 Fup NA 0.1456 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024787 Vd NA 1.285 L/kg 1compartment NA NA Human Human -DTXSID8024787 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8024787 TK.Half.Life NA 26.91 hours 1compartment NA NA Human Human -DTXSID8024787 Css NA 2.79 mg/L 3compartmentss NA 50% Human Human -DTXSID8024787 Css NA 13.82 mg/L 3compartmentss NA 95% Human Human -DTXSID8024787 Css NA 1.92 mg/L PBTK NA 50% Human Human -DTXSID8024787 Css NA 8.532 mg/L PBTK NA 95% Human Human -DTXSID8024787 Clint NA 0.8923 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024787 Fup NA 0.1456 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024787 Vd NA 1.019 L/kg 1compartment NA NA Rat Human -DTXSID8024787 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8024787 TK.Half.Life NA 9.114 hours 1compartment NA NA Rat Human -DTXSID8024787 Css NA 1.139 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024787 Css NA 4.616 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024787 Css NA 0.7361 mg/L PBTK NA 50% Rat Human -DTXSID8024787 Css NA 2.626 mg/L PBTK NA 95% Rat Human -DTXSID8024862 Clint NA 36.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024862 Fup NA 0.3105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024862 Vd NA 1.654 L/kg 1compartment NA NA Human Human +DTXSID8024733 TK.Half.Life NA 0.8823 hours 1compartment NA NA Rat Human +DTXSID8024733 Css NA 0.006792 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024733 Css NA 0.04018 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024733 Css NA 0.005654 mg/L PBTK NA 50% Rat Human +DTXSID8024733 Css NA 0.02983 mg/L PBTK NA 95% Rat Human +DTXSID8024781 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8024781 Fup NA 0.0767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8024781 Vd NA 1.073 L/kg 1compartment NA NA Human Human +DTXSID8024781 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID8024781 TK.Half.Life NA 106.5 hours 1compartment NA NA Human Human +DTXSID8024781 Css NA 14.53 mg/L 3compartmentss NA 50% Human Human +DTXSID8024781 Css NA 62.7 mg/L 3compartmentss NA 95% Human Human +DTXSID8024781 Css NA 9.275 mg/L PBTK NA 50% Human Human +DTXSID8024781 Css NA 37.16 mg/L PBTK NA 95% Human Human +DTXSID8024781 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8024781 Fup NA 0.0767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8024781 Vd NA 0.8292 L/kg 1compartment NA NA Rat Human +DTXSID8024781 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID8024781 TK.Half.Life NA 24.84 hours 1compartment NA NA Rat Human +DTXSID8024781 Css NA 0.9457 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024781 Css NA 3.387 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024781 Css NA 0.5884 mg/L PBTK NA 50% Rat Human +DTXSID8024781 Css NA 1.959 mg/L PBTK NA 95% Rat Human +DTXSID8024787 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024787 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024787 Vd NA 1.259 L/kg 1compartment NA NA Human Human +DTXSID8024787 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8024787 TK.Half.Life NA 2.747 hours 1compartment NA NA Human Human +DTXSID8024787 Css NA 0.201 mg/L 3compartmentss NA 50% Human Human +DTXSID8024787 Css NA 1.64 mg/L 3compartmentss NA 95% Human Human +DTXSID8024787 Css NA 0.1354 mg/L PBTK NA 50% Human Human +DTXSID8024787 Css NA 1.036 mg/L PBTK NA 95% Human Human +DTXSID8024787 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024787 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024787 Vd NA 0.9953 L/kg 1compartment NA NA Rat Human +DTXSID8024787 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8024787 TK.Half.Life NA 1.146 hours 1compartment NA NA Rat Human +DTXSID8024787 Css NA 0.02597 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024787 Css NA 0.1578 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024787 Css NA 0.0171 mg/L PBTK NA 50% Rat Human +DTXSID8024787 Css NA 0.09616 mg/L PBTK NA 95% Rat Human +DTXSID8024810 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024810 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024810 Vd NA 0.8913 L/kg 1compartment NA NA Human Human +DTXSID8024810 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8024810 TK.Half.Life NA 1.859 hours 1compartment NA NA Human Human +DTXSID8024810 Css NA 0.1424 mg/L 3compartmentss NA 50% Human Human +DTXSID8024810 Css NA 0.9686 mg/L 3compartmentss NA 95% Human Human +DTXSID8024810 Css NA 0.109 mg/L PBTK NA 50% Human Human +DTXSID8024810 Css NA 0.6578 mg/L PBTK NA 95% Human Human +DTXSID8024810 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024810 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024810 Vd NA 0.8068 L/kg 1compartment NA NA Rat Human +DTXSID8024810 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8024810 TK.Half.Life NA 0.9236 hours 1compartment NA NA Rat Human +DTXSID8024810 Css NA 0.00458 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024810 Css NA 0.03815 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024810 Css NA 0.003498 mg/L PBTK NA 50% Rat Human +DTXSID8024810 Css NA 0.02571 mg/L PBTK NA 95% Rat Human +DTXSID8024862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024862 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024862 Vd NA 1.679 L/kg 1compartment NA NA Human Human DTXSID8024862 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024862 TK.Half.Life NA 1.857 hours 1compartment NA NA Human Human -DTXSID8024862 Css NA 0.04948 mg/L 3compartmentss NA 50% Human Human -DTXSID8024862 Css NA 0.3554 mg/L 3compartmentss NA 95% Human Human -DTXSID8024862 Css NA 0.03783 mg/L PBTK NA 50% Human Human -DTXSID8024862 Css NA 0.2528 mg/L PBTK NA 95% Human Human -DTXSID8024862 Clint NA 36.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024862 Fup NA 0.3105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024862 Vd NA 1.326 L/kg 1compartment NA NA Rat Human +DTXSID8024862 TK.Half.Life NA 3.154 hours 1compartment NA NA Human Human +DTXSID8024862 Css NA 0.1326 mg/L 3compartmentss NA 50% Human Human +DTXSID8024862 Css NA 0.9392 mg/L 3compartmentss NA 95% Human Human +DTXSID8024862 Css NA 0.09521 mg/L PBTK NA 50% Human Human +DTXSID8024862 Css NA 0.6279 mg/L PBTK NA 95% Human Human +DTXSID8024862 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024862 Fup 0.196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024862 Vd NA 1.31 L/kg 1compartment NA NA Rat Human DTXSID8024862 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024862 TK.Half.Life NA 0.6963 hours 1compartment NA NA Rat Human -DTXSID8024862 Css NA 0.02709 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024862 Css NA 0.1536 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024862 Css NA 0.01994 mg/L PBTK NA 50% Rat Human -DTXSID8024862 Css NA 0.1035 mg/L PBTK NA 95% Rat Human +DTXSID8024862 TK.Half.Life NA 1.18 hours 1compartment NA NA Rat Human +DTXSID8024862 Css NA 0.01693 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024862 Css NA 0.0907 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024862 Css NA 0.01209 mg/L PBTK NA 50% Rat Human +DTXSID8024862 Css NA 0.06081 mg/L PBTK NA 95% Rat Human DTXSID8024864 Clint NA 0.01267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8024864 Fup NA 0.8283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024864 Vd NA 1.056 L/kg 1compartment NA NA Human Human +DTXSID8024864 Vd NA 1.112 L/kg 1compartment NA NA Human Human DTXSID8024864 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024864 TK.Half.Life NA 8.311 hours 1compartment NA NA Human Human -DTXSID8024864 Css NA 0.9084 mg/L 3compartmentss NA 50% Human Human -DTXSID8024864 Css NA 5.701 mg/L 3compartmentss NA 95% Human Human -DTXSID8024864 Css NA 0.7978 mg/L PBTK NA 50% Human Human -DTXSID8024864 Css NA 3.752 mg/L PBTK NA 95% Human Human +DTXSID8024864 TK.Half.Life NA 8.83 hours 1compartment NA NA Human Human +DTXSID8024864 Css NA 0.7625 mg/L 3compartmentss NA 50% Human Human +DTXSID8024864 Css NA 4.757 mg/L 3compartmentss NA 95% Human Human +DTXSID8024864 Css NA 0.6754 mg/L PBTK NA 50% Human Human +DTXSID8024864 Css NA 3.134 mg/L PBTK NA 95% Human Human DTXSID8024864 Clint NA 0.01267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8024864 Fup NA 0.8283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024864 Vd NA 1.02 L/kg 1compartment NA NA Rat Human +DTXSID8024864 Vd NA 1.063 L/kg 1compartment NA NA Rat Human DTXSID8024864 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024864 TK.Half.Life NA 2.705 hours 1compartment NA NA Rat Human -DTXSID8024864 Css NA 0.2306 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024864 Css NA 1.413 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024864 Css NA 0.1985 mg/L PBTK NA 50% Rat Human -DTXSID8024864 Css NA 0.8666 mg/L PBTK NA 95% Rat Human -DTXSID8024866 Clint NA 33.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024866 Fup NA 0.0063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024866 Vd NA 0.6764 L/kg 1compartment NA NA Human Human -DTXSID8024866 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8024866 TK.Half.Life NA 10.4 hours 1compartment NA NA Human Human -DTXSID8024866 Css NA 2.73 mg/L 3compartmentss NA 50% Human Human -DTXSID8024866 Css NA 28.2 mg/L 3compartmentss NA 95% Human Human -DTXSID8024866 Css NA 1.634 mg/L PBTK NA 50% Human Human -DTXSID8024866 Css NA 16.4 mg/L PBTK NA 95% Human Human -DTXSID8024866 Clint NA 33.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024866 Fup NA 0.0063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024866 Vd NA 0.5238 L/kg 1compartment NA NA Rat Human -DTXSID8024866 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024866 TK.Half.Life NA 5.196 hours 1compartment NA NA Rat Human -DTXSID8024866 Css NA 1.572 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024866 Css NA 13.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024866 Css NA 0.8734 mg/L PBTK NA 50% Rat Human -DTXSID8024866 Css NA 7.137 mg/L PBTK NA 95% Rat Human -DTXSID8024947 Clint NA 15.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024947 Fup NA 0.0557 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024947 Vd NA 3.107 L/kg 1compartment NA NA Human Human -DTXSID8024947 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID8024947 TK.Half.Life NA 96.06 hours 1compartment NA NA Human Human -DTXSID8024947 Css NA 3.726 mg/L 3compartmentss NA 50% Human Human -DTXSID8024947 Css NA 23.74 mg/L 3compartmentss NA 95% Human Human -DTXSID8024947 Css NA 2.606 mg/L PBTK NA 50% Human Human -DTXSID8024947 Css NA 16.08 mg/L PBTK NA 95% Human Human -DTXSID8024947 Clint NA 15.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024947 Fup NA 0.0557 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024947 Vd NA 2.329 L/kg 1compartment NA NA Rat Human -DTXSID8024947 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID8024947 TK.Half.Life NA 13.14 hours 1compartment NA NA Rat Human -DTXSID8024947 Css NA 2.101 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024947 Css NA 11.45 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024947 Css NA 1.397 mg/L PBTK NA 50% Rat Human -DTXSID8024947 Css NA 7.474 mg/L PBTK NA 95% Rat Human +DTXSID8024864 TK.Half.Life NA 2.827 hours 1compartment NA NA Rat Human +DTXSID8024864 Css NA 0.01455 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024864 Css NA 0.1103 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024864 Css NA 0.01252 mg/L PBTK NA 50% Rat Human +DTXSID8024864 Css NA 0.0747 mg/L PBTK NA 95% Rat Human +DTXSID8024866 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024866 Fup 0.0996 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024866 Vd NA 3.145 L/kg 1compartment NA NA Human Human +DTXSID8024866 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID8024866 TK.Half.Life NA 65.39 hours 1compartment NA NA Human Human +DTXSID8024866 Css NA 2.407 mg/L 3compartmentss NA 50% Human Human +DTXSID8024866 Css NA 15.74 mg/L 3compartmentss NA 95% Human Human +DTXSID8024866 Css NA 1.687 mg/L PBTK NA 50% Human Human +DTXSID8024866 Css NA 10.73 mg/L PBTK NA 95% Human Human +DTXSID8024866 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024866 Fup 0.0996 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024866 Vd NA 2.365 L/kg 1compartment NA NA Rat Human +DTXSID8024866 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID8024866 TK.Half.Life NA 8.997 hours 1compartment NA NA Rat Human +DTXSID8024866 Css NA 0.3098 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024866 Css NA 1.775 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024866 Css NA 0.2146 mg/L PBTK NA 50% Rat Human +DTXSID8024866 Css NA 1.234 mg/L PBTK NA 95% Rat Human DTXSID8024993 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8024993 Fup NA 0.4187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024993 Vd NA 0.376 L/kg 1compartment NA NA Human Human +DTXSID8024993 Vd NA 0.3663 L/kg 1compartment NA NA Human Human DTXSID8024993 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8024993 TK.Half.Life NA 5.81 hours 1compartment NA NA Human Human -DTXSID8024993 Css NA 1.862 mg/L 3compartmentss NA 50% Human Human -DTXSID8024993 Css NA 7.836 mg/L 3compartmentss NA 95% Human Human -DTXSID8024993 Css NA 1.29 mg/L PBTK NA 50% Human Human -DTXSID8024993 Css NA 4.843 mg/L PBTK NA 95% Human Human +DTXSID8024993 TK.Half.Life NA 5.663 hours 1compartment NA NA Human Human +DTXSID8024993 Css NA 1.812 mg/L 3compartmentss NA 50% Human Human +DTXSID8024993 Css NA 7.605 mg/L 3compartmentss NA 95% Human Human +DTXSID8024993 Css NA 1.247 mg/L PBTK NA 50% Human Human +DTXSID8024993 Css NA 4.694 mg/L PBTK NA 95% Human Human DTXSID8024993 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8024993 Fup NA 0.4187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024993 Vd NA 0.3832 L/kg 1compartment NA NA Rat Human +DTXSID8024993 Vd NA 0.3745 L/kg 1compartment NA NA Rat Human DTXSID8024993 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024993 TK.Half.Life NA 2.018 hours 1compartment NA NA Rat Human -DTXSID8024993 Css NA 0.5097 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024993 Css NA 1.882 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024993 Css NA 0.3338 mg/L PBTK NA 50% Rat Human -DTXSID8024993 Css NA 1.083 mg/L PBTK NA 95% Rat Human -DTXSID8024997 Clint NA 5.214 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024997 Fup NA 0.1193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8024997 Vd NA 2.091 L/kg 1compartment NA NA Human Human -DTXSID8024997 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8024997 TK.Half.Life NA 19.89 hours 1compartment NA NA Human Human -DTXSID8024997 Css NA 1.256 mg/L 3compartmentss NA 50% Human Human -DTXSID8024997 Css NA 7.398 mg/L 3compartmentss NA 95% Human Human -DTXSID8024997 Css NA 0.8666 mg/L PBTK NA 50% Human Human -DTXSID8024997 Css NA 4.739 mg/L PBTK NA 95% Human Human -DTXSID8024997 Clint NA 5.214 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024997 Fup NA 0.1193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8024997 Vd NA 1.587 L/kg 1compartment NA NA Rat Human +DTXSID8024993 TK.Half.Life NA 1.973 hours 1compartment NA NA Rat Human +DTXSID8024993 Css NA 0.1159 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024993 Css NA 0.4248 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024993 Css NA 0.07817 mg/L PBTK NA 50% Rat Human +DTXSID8024993 Css NA 0.2528 mg/L PBTK NA 95% Rat Human +DTXSID8024997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024997 Fup 0.053 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8024997 Vd NA 1.532 L/kg 1compartment NA NA Human Human +DTXSID8024997 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8024997 TK.Half.Life NA 6.94 hours 1compartment NA NA Human Human +DTXSID8024997 Css NA 0.5949 mg/L 3compartmentss NA 50% Human Human +DTXSID8024997 Css NA 4.454 mg/L 3compartmentss NA 95% Human Human +DTXSID8024997 Css NA 0.3824 mg/L PBTK NA 50% Human Human +DTXSID8024997 Css NA 2.789 mg/L PBTK NA 95% Human Human +DTXSID8024997 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024997 Fup 0.053 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8024997 Vd NA 1.153 L/kg 1compartment NA NA Rat Human DTXSID8024997 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8024997 TK.Half.Life NA 6.043 hours 1compartment NA NA Rat Human -DTXSID8024997 Css NA 0.654 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024997 Css NA 2.684 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024997 Css NA 0.4278 mg/L PBTK NA 50% Rat Human -DTXSID8024997 Css NA 1.616 mg/L PBTK NA 95% Rat Human +DTXSID8024997 TK.Half.Life NA 2.655 hours 1compartment NA NA Rat Human +DTXSID8024997 Css NA 0.07722 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024997 Css NA 0.4732 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024997 Css NA 0.04834 mg/L PBTK NA 50% Rat Human +DTXSID8024997 Css NA 0.282 mg/L PBTK NA 95% Rat Human DTXSID8024999 Clint 387 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8024999 Fup 1.21e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8024999 Vd NA 0.1785 L/kg 1compartment NA NA Human Human DTXSID8024999 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID8024999 TK.Half.Life NA 13.82 hours 1compartment NA NA Human Human -DTXSID8024999 Css NA 0.1402 mg/L 3compartmentss NA 50% Human Human -DTXSID8024999 Css NA 2.426 mg/L 3compartmentss NA 95% Human Human -DTXSID8024999 Css NA 0.08441 mg/L PBTK NA 50% Human Human -DTXSID8024999 Css NA 1.397 mg/L PBTK NA 95% Human Human +DTXSID8024999 Css NA 0.1353 mg/L 3compartmentss NA 50% Human Human +DTXSID8024999 Css NA 2.361 mg/L 3compartmentss NA 95% Human Human +DTXSID8024999 Css NA 0.08125 mg/L PBTK NA 50% Human Human +DTXSID8024999 Css NA 1.375 mg/L PBTK NA 95% Human Human DTXSID8024999 Clint 387 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8024999 Fup 1.21e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8024999 Vd NA 0.1673 L/kg 1compartment NA NA Rat Human DTXSID8024999 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8024999 TK.Half.Life NA 9.038 hours 1compartment NA NA Rat Human -DTXSID8024999 Css NA 0.08152 mg/L 3compartmentss NA 50% Rat Human -DTXSID8024999 Css NA 1.212 mg/L 3compartmentss NA 95% Rat Human -DTXSID8024999 Css NA 0.04575 mg/L PBTK NA 50% Rat Human -DTXSID8024999 Css NA 0.6637 mg/L PBTK NA 95% Rat Human -DTXSID8025040 Clint NA 19.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025040 Fup NA 0.0396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025040 Vd NA 2.682 L/kg 1compartment NA NA Human Human -DTXSID8025040 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8025040 TK.Half.Life NA 28.03 hours 1compartment NA NA Human Human -DTXSID8025040 Css NA 1.399 mg/L 3compartmentss NA 50% Human Human -DTXSID8025040 Css NA 9.447 mg/L 3compartmentss NA 95% Human Human -DTXSID8025040 Css NA 0.9404 mg/L PBTK NA 50% Human Human -DTXSID8025040 Css NA 6.122 mg/L PBTK NA 95% Human Human -DTXSID8025040 Clint NA 19.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025040 Fup NA 0.0396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025040 Vd NA 2.008 L/kg 1compartment NA NA Rat Human -DTXSID8025040 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8025040 TK.Half.Life NA 6.172 hours 1compartment NA NA Rat Human -DTXSID8025040 Css NA 0.7771 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025040 Css NA 4.227 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025040 Css NA 0.5001 mg/L PBTK NA 50% Rat Human -DTXSID8025040 Css NA 2.63 mg/L PBTK NA 95% Rat Human -DTXSID8025046 Clint NA 728.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025046 Fup NA 0.2226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025046 Vd NA 1.092 L/kg 1compartment NA NA Human Human +DTXSID8024999 Css NA 0.01771 mg/L 3compartmentss NA 50% Rat Human +DTXSID8024999 Css NA 0.2749 mg/L 3compartmentss NA 95% Rat Human +DTXSID8024999 Css NA 0.01037 mg/L PBTK NA 50% Rat Human +DTXSID8024999 Css NA 0.1556 mg/L PBTK NA 95% Rat Human +DTXSID8025040 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025040 Fup 0.0591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025040 Vd NA 2.323 L/kg 1compartment NA NA Human Human +DTXSID8025040 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8025040 TK.Half.Life NA 13.1 hours 1compartment NA NA Human Human +DTXSID8025040 Css NA 0.6917 mg/L 3compartmentss NA 50% Human Human +DTXSID8025040 Css NA 4.957 mg/L 3compartmentss NA 95% Human Human +DTXSID8025040 Css NA 0.464 mg/L PBTK NA 50% Human Human +DTXSID8025040 Css NA 3.204 mg/L PBTK NA 95% Human Human +DTXSID8025040 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025040 Fup 0.0591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025040 Vd NA 1.743 L/kg 1compartment NA NA Rat Human +DTXSID8025040 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8025040 TK.Half.Life NA 3.705 hours 1compartment NA NA Rat Human +DTXSID8025040 Css NA 0.09054 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025040 Css NA 0.4927 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025040 Css NA 0.05973 mg/L PBTK NA 50% Rat Human +DTXSID8025040 Css NA 0.3149 mg/L PBTK NA 95% Rat Human +DTXSID8025046 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025046 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025046 Vd NA 1.302 L/kg 1compartment NA NA Human Human DTXSID8025046 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025046 TK.Half.Life NA 0.872 hours 1compartment NA NA Human Human -DTXSID8025046 Css NA 0.00319 mg/L 3compartmentss NA 50% Human Human -DTXSID8025046 Css NA 0.02339 mg/L 3compartmentss NA 95% Human Human -DTXSID8025046 Css NA 0.002272 mg/L PBTK NA 50% Human Human -DTXSID8025046 Css NA 0.01533 mg/L PBTK NA 95% Human Human -DTXSID8025046 Clint NA 728.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025046 Fup NA 0.2226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025046 Vd NA 0.8996 L/kg 1compartment NA NA Rat Human +DTXSID8025046 TK.Half.Life NA 1.713 hours 1compartment NA NA Human Human +DTXSID8025046 Css NA 0.06904 mg/L 3compartmentss NA 50% Human Human +DTXSID8025046 Css NA 0.5314 mg/L 3compartmentss NA 95% Human Human +DTXSID8025046 Css NA 0.05243 mg/L PBTK NA 50% Human Human +DTXSID8025046 Css NA 0.362 mg/L PBTK NA 95% Human Human +DTXSID8025046 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025046 Fup 0.31 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025046 Vd NA 1.076 L/kg 1compartment NA NA Rat Human DTXSID8025046 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025046 TK.Half.Life NA 0.3164 hours 1compartment NA NA Rat Human -DTXSID8025046 Css NA 0.001768 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025046 Css NA 0.01102 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025046 Css NA 0.001207 mg/L PBTK NA 50% Rat Human -DTXSID8025046 Css NA 0.007176 mg/L PBTK NA 95% Rat Human -DTXSID8025094 Clint NA 767.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025094 Fup NA 0.1539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025094 Vd NA 0.5792 L/kg 1compartment NA NA Human Human +DTXSID8025046 TK.Half.Life NA 0.711 hours 1compartment NA NA Rat Human +DTXSID8025046 Css NA 0.008756 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025046 Css NA 0.05028 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025046 Css NA 0.006634 mg/L PBTK NA 50% Rat Human +DTXSID8025046 Css NA 0.03441 mg/L PBTK NA 95% Rat Human +DTXSID8025094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025094 Fup 0.36 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025094 Vd NA 0.9761 L/kg 1compartment NA NA Human Human DTXSID8025094 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025094 TK.Half.Life NA 0.5093 hours 1compartment NA NA Human Human -DTXSID8025094 Css NA 0.00498 mg/L 3compartmentss NA 50% Human Human -DTXSID8025094 Css NA 0.04175 mg/L 3compartmentss NA 95% Human Human -DTXSID8025094 Css NA 0.00327 mg/L PBTK NA 50% Human Human -DTXSID8025094 Css NA 0.02575 mg/L PBTK NA 95% Human Human -DTXSID8025094 Clint NA 767.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025094 Fup NA 0.1539 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025094 Vd NA 0.5127 L/kg 1compartment NA NA Rat Human +DTXSID8025094 TK.Half.Life NA 1.151 hours 1compartment NA NA Human Human +DTXSID8025094 Css NA 0.05497 mg/L 3compartmentss NA 50% Human Human +DTXSID8025094 Css NA 0.4292 mg/L 3compartmentss NA 95% Human Human +DTXSID8025094 Css NA 0.04166 mg/L PBTK NA 50% Human Human +DTXSID8025094 Css NA 0.2982 mg/L PBTK NA 95% Human Human +DTXSID8025094 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025094 Fup 0.36 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025094 Vd NA 0.8595 L/kg 1compartment NA NA Rat Human DTXSID8025094 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025094 TK.Half.Life NA 0.2006 hours 1compartment NA NA Rat Human -DTXSID8025094 Css NA 0.002874 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025094 Css NA 0.01891 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025094 Css NA 0.001767 mg/L PBTK NA 50% Rat Human -DTXSID8025094 Css NA 0.01123 mg/L PBTK NA 95% Rat Human -DTXSID8025096 Clint NA 0.0543 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025096 Fup NA 0.7113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025096 Vd NA 1.137 L/kg 1compartment NA NA Human Human -DTXSID8025096 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8025096 TK.Half.Life NA 10.01 hours 1compartment NA NA Human Human -DTXSID8025096 Css NA 0.9284 mg/L 3compartmentss NA 50% Human Human -DTXSID8025096 Css NA 5.896 mg/L 3compartmentss NA 95% Human Human -DTXSID8025096 Css NA 0.8175 mg/L PBTK NA 50% Human Human -DTXSID8025096 Css NA 3.922 mg/L PBTK NA 95% Human Human -DTXSID8025096 Clint NA 0.0543 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025096 Fup NA 0.7113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025096 Vd NA 1.059 L/kg 1compartment NA NA Rat Human +DTXSID8025094 TK.Half.Life NA 0.5196 hours 1compartment NA NA Rat Human +DTXSID8025094 Css NA 0.006784 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025094 Css NA 0.04008 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025094 Css NA 0.005187 mg/L PBTK NA 50% Rat Human +DTXSID8025094 Css NA 0.02793 mg/L PBTK NA 95% Rat Human +DTXSID8025096 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025096 Fup 0.6 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025096 Vd NA 1.027 L/kg 1compartment NA NA Human Human +DTXSID8025096 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8025096 TK.Half.Life NA 0.9113 hours 1compartment NA NA Human Human +DTXSID8025096 Css NA 0.03199 mg/L 3compartmentss NA 50% Human Human +DTXSID8025096 Css NA 0.362 mg/L 3compartmentss NA 95% Human Human +DTXSID8025096 Css NA 0.02668 mg/L PBTK NA 50% Human Human +DTXSID8025096 Css NA 0.2508 mg/L PBTK NA 95% Human Human +DTXSID8025096 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025096 Fup 0.6 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025096 Vd NA 0.9552 L/kg 1compartment NA NA Rat Human DTXSID8025096 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025096 TK.Half.Life NA 3.184 hours 1compartment NA NA Rat Human -DTXSID8025096 Css NA 0.256 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025096 Css NA 1.684 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025096 Css NA 0.2172 mg/L PBTK NA 50% Rat Human -DTXSID8025096 Css NA 1.021 mg/L PBTK NA 95% Rat Human -DTXSID8025258 Clint NA 24.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025258 Fup NA 0.6803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025258 Vd NA 6.915 L/kg 1compartment NA NA Human Human +DTXSID8025096 TK.Half.Life NA 0.4183 hours 1compartment NA NA Rat Human +DTXSID8025096 Css NA 0.003911 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025096 Css NA 0.03647 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025096 Css NA 0.003302 mg/L PBTK NA 50% Rat Human +DTXSID8025096 Css NA 0.02447 mg/L PBTK NA 95% Rat Human +DTXSID8025258 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025258 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025258 Vd NA 0.2976 L/kg 1compartment NA NA Human Human DTXSID8025258 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025258 TK.Half.Life NA 3.466 hours 1compartment NA NA Human Human -DTXSID8025258 Css NA 0.01272 mg/L 3compartmentss NA 50% Human Human -DTXSID8025258 Css NA 0.1708 mg/L 3compartmentss NA 95% Human Human -DTXSID8025258 Css NA 0.02323 mg/L PBTK NA 50% Human Human -DTXSID8025258 Css NA 0.1922 mg/L PBTK NA 95% Human Human -DTXSID8025258 Clint NA 24.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025258 Fup NA 0.6803 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025258 Vd NA 7.003 L/kg 1compartment NA NA Rat Human +DTXSID8025258 TK.Half.Life NA 1.334 hours 1compartment NA NA Human Human +DTXSID8025258 Css NA 0.5643 mg/L 3compartmentss NA 50% Human Human +DTXSID8025258 Css NA 3.725 mg/L 3compartmentss NA 95% Human Human +DTXSID8025258 Css NA 0.353 mg/L PBTK NA 50% Human Human +DTXSID8025258 Css NA 2.23 mg/L PBTK NA 95% Human Human +DTXSID8025258 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025258 Fup 0.152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025258 Vd NA 0.3061 L/kg 1compartment NA NA Rat Human DTXSID8025258 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025258 TK.Half.Life NA 1.691 hours 1compartment NA NA Rat Human -DTXSID8025258 Css NA 0.006393 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025258 Css NA 0.07591 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025258 Css NA 0.01206 mg/L PBTK NA 50% Rat Human -DTXSID8025258 Css NA 0.07981 mg/L PBTK NA 95% Rat Human -DTXSID8025331 Clint NA 0.01529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025331 Fup NA 0.4956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025331 Vd NA 1.402 L/kg 1compartment NA NA Human Human -DTXSID8025331 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8025331 TK.Half.Life NA 20.99 hours 1compartment NA NA Human Human -DTXSID8025331 Css NA 1.509 mg/L 3compartmentss NA 50% Human Human -DTXSID8025331 Css NA 7.675 mg/L 3compartmentss NA 95% Human Human -DTXSID8025331 Css NA 1.259 mg/L PBTK NA 50% Human Human -DTXSID8025331 Css NA 5.14 mg/L PBTK NA 95% Human Human -DTXSID8025331 Clint NA 0.01529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025331 Fup NA 0.4956 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025331 Vd NA 1.197 L/kg 1compartment NA NA Rat Human +DTXSID8025258 TK.Half.Life NA 0.8185 hours 1compartment NA NA Rat Human +DTXSID8025258 Css NA 0.06878 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025258 Css NA 0.3367 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025258 Css NA 0.04208 mg/L PBTK NA 50% Rat Human +DTXSID8025258 Css NA 0.194 mg/L PBTK NA 95% Rat Human +DTXSID8025331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025331 Fup 0.0842 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025331 Vd NA 0.4713 L/kg 1compartment NA NA Human Human +DTXSID8025331 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8025331 TK.Half.Life NA 1.369 hours 1compartment NA NA Human Human +DTXSID8025331 Css NA 0.3449 mg/L 3compartmentss NA 50% Human Human +DTXSID8025331 Css NA 2.805 mg/L 3compartmentss NA 95% Human Human +DTXSID8025331 Css NA 0.2136 mg/L PBTK NA 50% Human Human +DTXSID8025331 Css NA 1.689 mg/L PBTK NA 95% Human Human +DTXSID8025331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025331 Fup 0.0842 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025331 Vd NA 0.4091 L/kg 1compartment NA NA Rat Human DTXSID8025331 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025331 TK.Half.Life NA 5.479 hours 1compartment NA NA Rat Human -DTXSID8025331 Css NA 0.4114 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025331 Css NA 1.863 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025331 Css NA 0.3322 mg/L PBTK NA 50% Rat Human -DTXSID8025331 Css NA 1.15 mg/L PBTK NA 95% Rat Human +DTXSID8025331 TK.Half.Life NA 0.7087 hours 1compartment NA NA Rat Human +DTXSID8025331 Css NA 0.04478 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025331 Css NA 0.279 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025331 Css NA 0.02697 mg/L PBTK NA 50% Rat Human +DTXSID8025331 Css NA 0.1617 mg/L PBTK NA 95% Rat Human DTXSID8025337 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8025337 Fup NA 0.599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8025337 Vd NA 0.5507 L/kg 1compartment NA NA Human Human DTXSID8025337 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8025337 TK.Half.Life NA 5.95 hours 1compartment NA NA Human Human -DTXSID8025337 Css NA 1.287 mg/L 3compartmentss NA 50% Human Human -DTXSID8025337 Css NA 8.803 mg/L 3compartmentss NA 95% Human Human -DTXSID8025337 Css NA 0.9826 mg/L PBTK NA 50% Human Human -DTXSID8025337 Css NA 5.459 mg/L PBTK NA 95% Human Human +DTXSID8025337 Css NA 1.094 mg/L 3compartmentss NA 50% Human Human +DTXSID8025337 Css NA 7.47 mg/L 3compartmentss NA 95% Human Human +DTXSID8025337 Css NA 0.8411 mg/L PBTK NA 50% Human Human +DTXSID8025337 Css NA 4.659 mg/L PBTK NA 95% Human Human DTXSID8025337 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8025337 Fup NA 0.599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025337 Vd NA 0.5805 L/kg 1compartment NA NA Rat Human +DTXSID8025337 Vd 0.72 0.5805 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID8025337 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025337 TK.Half.Life NA 2.137 hours 1compartment NA NA Rat Human -DTXSID8025337 Css NA 0.3425 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025337 Css NA 2.084 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025337 Css NA 0.2504 mg/L PBTK NA 50% Rat Human -DTXSID8025337 Css NA 1.208 mg/L PBTK NA 95% Rat Human -DTXSID8025466 Clint NA 4.092 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025466 Fup NA 0.0342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025466 Vd NA 3.114 L/kg 1compartment NA NA Human Human -DTXSID8025466 Days.Css NA 94 Days PBTK NA NA Human Human -DTXSID8025466 TK.Half.Life NA 413.3 hours 1compartment NA NA Human Human -DTXSID8025466 Css NA 16.45 mg/L 3compartmentss NA 50% Human Human -DTXSID8025466 Css NA 97.61 mg/L 3compartmentss NA 95% Human Human -DTXSID8025466 Css NA 11.48 mg/L PBTK NA 50% Human Human -DTXSID8025466 Css NA 66.16 mg/L PBTK NA 95% Human Human -DTXSID8025466 Clint NA 4.092 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025466 Fup NA 0.0342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025466 Vd NA 2.333 L/kg 1compartment NA NA Rat Human -DTXSID8025466 Days.Css NA 51 Days PBTK NA NA Rat Human -DTXSID8025466 TK.Half.Life NA 53.94 hours 1compartment NA NA Rat Human -DTXSID8025466 Css NA 9.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025466 Css NA 46.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025466 Css NA 6.081 mg/L PBTK NA 50% Rat Human -DTXSID8025466 Css NA 30.1 mg/L PBTK NA 95% Rat Human +DTXSID8025337 TK.Half.Life 14 2.137 hours 1compartment National Toxicology Program NA Rat Human +DTXSID8025337 Css 1.2 0.0209 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID8025337 Css 1.2 0.1742 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID8025337 Css 1.2 0.01541 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID8025337 Css 1.2 0.1074 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID8025464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025464 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025464 Vd NA 1.229 L/kg 1compartment NA NA Human Human +DTXSID8025464 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8025464 TK.Half.Life NA 1.364 hours 1compartment NA NA Human Human +DTXSID8025464 Css NA 0.04908 mg/L 3compartmentss NA 50% Human Human +DTXSID8025464 Css NA 0.3929 mg/L 3compartmentss NA 95% Human Human +DTXSID8025464 Css NA 0.03879 mg/L PBTK NA 50% Human Human +DTXSID8025464 Css NA 0.2771 mg/L PBTK NA 95% Human Human +DTXSID8025464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025464 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025464 Vd NA 1.087 L/kg 1compartment NA NA Rat Human +DTXSID8025464 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8025464 TK.Half.Life NA 0.6091 hours 1compartment NA NA Rat Human +DTXSID8025464 Css NA 0.006062 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025464 Css NA 0.03722 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025464 Css NA 0.004844 mg/L PBTK NA 50% Rat Human +DTXSID8025464 Css NA 0.02625 mg/L PBTK NA 95% Rat Human DTXSID8025591 Clint NA 0.3976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8025591 Fup NA 0.8751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025591 Vd NA 1.531 L/kg 1compartment NA NA Human Human +DTXSID8025591 Vd NA 1.756 L/kg 1compartment NA NA Human Human DTXSID8025591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025591 TK.Half.Life NA 6.918 hours 1compartment NA NA Human Human -DTXSID8025591 Css NA 0.4818 mg/L 3compartmentss NA 50% Human Human -DTXSID8025591 Css NA 3.169 mg/L 3compartmentss NA 95% Human Human -DTXSID8025591 Css NA 0.4593 mg/L PBTK NA 50% Human Human -DTXSID8025591 Css NA 2.186 mg/L PBTK NA 95% Human Human +DTXSID8025591 TK.Half.Life NA 7.961 hours 1compartment NA NA Human Human +DTXSID8025591 Css NA 0.3989 mg/L 3compartmentss NA 50% Human Human +DTXSID8025591 Css NA 2.684 mg/L 3compartmentss NA 95% Human Human +DTXSID8025591 Css NA 0.3898 mg/L PBTK NA 50% Human Human +DTXSID8025591 Css NA 1.869 mg/L PBTK NA 95% Human Human DTXSID8025591 Clint NA 0.3976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8025591 Fup NA 0.8751 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025591 Vd NA 1.575 L/kg 1compartment NA NA Rat Human +DTXSID8025591 Vd NA 1.794 L/kg 1compartment NA NA Rat Human DTXSID8025591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025591 TK.Half.Life NA 3.02 hours 1compartment NA NA Rat Human -DTXSID8025591 Css NA 0.1533 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025591 Css NA 1.005 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025591 Css NA 0.1453 mg/L PBTK NA 50% Rat Human -DTXSID8025591 Css NA 0.6362 mg/L PBTK NA 95% Rat Human -DTXSID8025593 Clint NA 23.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025593 Fup NA 0.0713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025593 Vd NA 0.7918 L/kg 1compartment NA NA Human Human +DTXSID8025591 TK.Half.Life NA 3.447 hours 1compartment NA NA Rat Human +DTXSID8025591 Css NA 0.00953 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025591 Css NA 0.07818 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025591 Css NA 0.00906 mg/L PBTK NA 50% Rat Human +DTXSID8025591 Css NA 0.05631 mg/L PBTK NA 95% Rat Human +DTXSID8025593 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025593 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025593 Vd NA 0.7654 L/kg 1compartment NA NA Human Human DTXSID8025593 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025593 TK.Half.Life NA 2.46 hours 1compartment NA NA Human Human -DTXSID8025593 Css NA 0.3657 mg/L 3compartmentss NA 50% Human Human -DTXSID8025593 Css NA 2.762 mg/L 3compartmentss NA 95% Human Human -DTXSID8025593 Css NA 0.2294 mg/L PBTK NA 50% Human Human -DTXSID8025593 Css NA 1.677 mg/L PBTK NA 95% Human Human -DTXSID8025593 Clint NA 23.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025593 Fup NA 0.0713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025593 Vd NA 0.626 L/kg 1compartment NA NA Rat Human +DTXSID8025593 TK.Half.Life NA 1.427 hours 1compartment NA NA Human Human +DTXSID8025593 Css NA 0.1423 mg/L 3compartmentss NA 50% Human Human +DTXSID8025593 Css NA 1.105 mg/L 3compartmentss NA 95% Human Human +DTXSID8025593 Css NA 0.09556 mg/L PBTK NA 50% Human Human +DTXSID8025593 Css NA 0.6891 mg/L PBTK NA 95% Human Human +DTXSID8025593 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025593 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025593 Vd NA 0.6472 L/kg 1compartment NA NA Rat Human DTXSID8025593 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025593 TK.Half.Life NA 1.13 hours 1compartment NA NA Rat Human -DTXSID8025593 Css NA 0.205 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025593 Css NA 1.119 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025593 Css NA 0.1211 mg/L PBTK NA 50% Rat Human -DTXSID8025593 Css NA 0.6428 mg/L PBTK NA 95% Rat Human +DTXSID8025593 TK.Half.Life NA 0.6678 hours 1compartment NA NA Rat Human +DTXSID8025593 Css NA 0.01829 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025593 Css NA 0.105 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025593 Css NA 0.01202 mg/L PBTK NA 50% Rat Human +DTXSID8025593 Css NA 0.06508 mg/L PBTK NA 95% Rat Human DTXSID8025595 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID8025595 Fup 1 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8025595 Vd NA 0.8218 L/kg 1compartment NA NA Human Human +DTXSID8025595 Vd NA 0.922 L/kg 1compartment NA NA Human Human DTXSID8025595 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025595 TK.Half.Life NA 5.324 hours 1compartment NA NA Human Human -DTXSID8025595 Css NA 0.8144 mg/L 3compartmentss NA 50% Human Human -DTXSID8025595 Css NA 5.621 mg/L 3compartmentss NA 95% Human Human -DTXSID8025595 Css NA 0.6937 mg/L PBTK NA 50% Human Human -DTXSID8025595 Css NA 3.755 mg/L PBTK NA 95% Human Human +DTXSID8025595 TK.Half.Life NA 6.001 hours 1compartment NA NA Human Human +DTXSID8025595 Css NA 0.7656 mg/L 3compartmentss NA 50% Human Human +DTXSID8025595 Css NA 5.61 mg/L 3compartmentss NA 95% Human Human +DTXSID8025595 Css NA 0.6737 mg/L PBTK NA 50% Human Human +DTXSID8025595 Css NA 3.679 mg/L PBTK NA 95% Human Human DTXSID8025595 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID8025595 Fup 1 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8025595 Vd NA 0.8528 L/kg 1compartment NA NA Rat Human +DTXSID8025595 Vd NA 0.9376 L/kg 1compartment NA NA Rat Human DTXSID8025595 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025595 TK.Half.Life NA 1.88 hours 1compartment NA NA Rat Human -DTXSID8025595 Css NA 0.205 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025595 Css NA 1.305 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025595 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID8025595 Css NA 0.7895 mg/L PBTK NA 95% Rat Human +DTXSID8025595 TK.Half.Life NA 2.07 hours 1compartment NA NA Rat Human +DTXSID8025595 Css NA 0.04497 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025595 Css NA 0.2841 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025595 Css NA 0.0401 mg/L PBTK NA 50% Rat Human +DTXSID8025595 Css NA 0.18 mg/L PBTK NA 95% Rat Human DTXSID8025599 Clint NA 1.807 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8025599 Fup NA 0.9805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025599 Vd NA 2.502 L/kg 1compartment NA NA Human Human +DTXSID8025599 Vd NA 1.032 L/kg 1compartment NA NA Human Human DTXSID8025599 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025599 TK.Half.Life NA 8.514 hours 1compartment NA NA Human Human -DTXSID8025599 Css NA 0.2775 mg/L 3compartmentss NA 50% Human Human -DTXSID8025599 Css NA 1.939 mg/L 3compartmentss NA 95% Human Human -DTXSID8025599 Css NA 0.2665 mg/L PBTK NA 50% Human Human -DTXSID8025599 Css NA 1.449 mg/L PBTK NA 95% Human Human +DTXSID8025599 TK.Half.Life NA 2.039 hours 1compartment NA NA Human Human +DTXSID8025599 Css NA 0.1672 mg/L 3compartmentss NA 50% Human Human +DTXSID8025599 Css NA 1.32 mg/L 3compartmentss NA 95% Human Human +DTXSID8025599 Css NA 0.148 mg/L PBTK NA 50% Human Human +DTXSID8025599 Css NA 0.9036 mg/L PBTK NA 95% Human Human DTXSID8025599 Clint NA 1.807 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8025599 Fup NA 0.9805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025599 Vd NA 2.047 L/kg 1compartment NA NA Rat Human +DTXSID8025599 Vd NA 1.025 L/kg 1compartment NA NA Rat Human DTXSID8025599 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025599 TK.Half.Life NA 2.386 hours 1compartment NA NA Rat Human -DTXSID8025599 Css NA 0.1154 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025599 Css NA 0.6979 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025599 Css NA 0.1113 mg/L PBTK NA 50% Rat Human -DTXSID8025599 Css NA 0.4708 mg/L PBTK NA 95% Rat Human -DTXSID8025628 Clint NA 7.822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025628 Fup NA 0.4606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025628 Vd NA 1.115 L/kg 1compartment NA NA Human Human +DTXSID8025599 TK.Half.Life NA 1.026 hours 1compartment NA NA Rat Human +DTXSID8025599 Css NA 0.004703 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025599 Css NA 0.04444 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025599 Css NA 0.004155 mg/L PBTK NA 50% Rat Human +DTXSID8025599 Css NA 0.03149 mg/L PBTK NA 95% Rat Human +DTXSID8025628 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025628 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025628 Vd NA 0.9622 L/kg 1compartment NA NA Human Human DTXSID8025628 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025628 TK.Half.Life NA 1.826 hours 1compartment NA NA Human Human -DTXSID8025628 Css NA 0.1182 mg/L 3compartmentss NA 50% Human Human -DTXSID8025628 Css NA 0.846 mg/L 3compartmentss NA 95% Human Human -DTXSID8025628 Css NA 0.09498 mg/L PBTK NA 50% Human Human -DTXSID8025628 Css NA 0.5889 mg/L PBTK NA 95% Human Human -DTXSID8025628 Clint NA 7.822 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025628 Fup NA 0.4606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025628 Vd NA 0.9854 L/kg 1compartment NA NA Rat Human +DTXSID8025628 TK.Half.Life NA 1.346 hours 1compartment NA NA Human Human +DTXSID8025628 Css NA 0.07804 mg/L 3compartmentss NA 50% Human Human +DTXSID8025628 Css NA 0.5732 mg/L 3compartmentss NA 95% Human Human +DTXSID8025628 Css NA 0.05639 mg/L PBTK NA 50% Human Human +DTXSID8025628 Css NA 0.3879 mg/L PBTK NA 95% Human Human +DTXSID8025628 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025628 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025628 Vd NA 0.8216 L/kg 1compartment NA NA Rat Human DTXSID8025628 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025628 TK.Half.Life NA 0.8556 hours 1compartment NA NA Rat Human -DTXSID8025628 Css NA 0.05969 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025628 Css NA 0.3336 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025628 Css NA 0.04649 mg/L PBTK NA 50% Rat Human -DTXSID8025628 Css NA 0.2175 mg/L PBTK NA 95% Rat Human -DTXSID8025670 Clint NA 2.003 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025670 Fup NA 0.1491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025670 Vd NA 0.7228 L/kg 1compartment NA NA Human Human +DTXSID8025628 TK.Half.Life NA 0.6027 hours 1compartment NA NA Rat Human +DTXSID8025628 Css NA 0.009818 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025628 Css NA 0.05301 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025628 Css NA 0.0071 mg/L PBTK NA 50% Rat Human +DTXSID8025628 Css NA 0.03552 mg/L PBTK NA 95% Rat Human +DTXSID8025670 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025670 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025670 Vd NA 0.7704 L/kg 1compartment NA NA Human Human DTXSID8025670 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025670 TK.Half.Life NA 7.76 hours 1compartment NA NA Human Human -DTXSID8025670 Css NA 1.484 mg/L 3compartmentss NA 50% Human Human -DTXSID8025670 Css NA 8.413 mg/L 3compartmentss NA 95% Human Human -DTXSID8025670 Css NA 0.9775 mg/L PBTK NA 50% Human Human -DTXSID8025670 Css NA 5.119 mg/L PBTK NA 95% Human Human -DTXSID8025670 Clint NA 2.003 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025670 Fup NA 0.1491 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025670 Vd NA 0.6026 L/kg 1compartment NA NA Rat Human +DTXSID8025670 TK.Half.Life NA 1.422 hours 1compartment NA NA Human Human +DTXSID8025670 Css NA 0.1298 mg/L 3compartmentss NA 50% Human Human +DTXSID8025670 Css NA 0.9736 mg/L 3compartmentss NA 95% Human Human +DTXSID8025670 Css NA 0.0871 mg/L PBTK NA 50% Human Human +DTXSID8025670 Css NA 0.6273 mg/L PBTK NA 95% Human Human +DTXSID8025670 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025670 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025670 Vd NA 0.6426 L/kg 1compartment NA NA Rat Human DTXSID8025670 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025670 TK.Half.Life NA 3.443 hours 1compartment NA NA Rat Human -DTXSID8025670 Css NA 0.6886 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025670 Css NA 2.854 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025670 Css NA 0.4278 mg/L PBTK NA 50% Rat Human -DTXSID8025670 Css NA 1.621 mg/L PBTK NA 95% Rat Human -DTXSID8025707 Clint NA 30.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025707 Fup NA 0.4761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025707 Vd NA 0.8639 L/kg 1compartment NA NA Human Human -DTXSID8025707 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025707 TK.Half.Life NA 0.7925 hours 1compartment NA NA Human Human -DTXSID8025707 Css NA 0.03146 mg/L 3compartmentss NA 50% Human Human -DTXSID8025707 Css NA 0.2694 mg/L 3compartmentss NA 95% Human Human -DTXSID8025707 Css NA 0.0245 mg/L PBTK NA 50% Human Human -DTXSID8025707 Css NA 0.1864 mg/L PBTK NA 95% Human Human -DTXSID8025707 Clint NA 30.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025707 Fup NA 0.4761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025707 Vd NA 0.8084 L/kg 1compartment NA NA Rat Human +DTXSID8025670 TK.Half.Life NA 0.6527 hours 1compartment NA NA Rat Human +DTXSID8025670 Css NA 0.01678 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025670 Css NA 0.08842 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025670 Css NA 0.01109 mg/L PBTK NA 50% Rat Human +DTXSID8025670 Css NA 0.05594 mg/L PBTK NA 95% Rat Human +DTXSID8025703 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025703 Fup 0.0271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025703 Vd NA 2.75 L/kg 1compartment NA NA Human Human +DTXSID8025703 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8025703 TK.Half.Life NA 34.99 hours 1compartment NA NA Human Human +DTXSID8025703 Css NA 1.675 mg/L 3compartmentss NA 50% Human Human +DTXSID8025703 Css NA 12.38 mg/L 3compartmentss NA 95% Human Human +DTXSID8025703 Css NA 1.13 mg/L PBTK NA 50% Human Human +DTXSID8025703 Css NA 7.915 mg/L PBTK NA 95% Human Human +DTXSID8025703 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025703 Fup 0.0271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025703 Vd NA 2.057 L/kg 1compartment NA NA Rat Human +DTXSID8025703 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8025703 TK.Half.Life NA 7.223 hours 1compartment NA NA Rat Human +DTXSID8025703 Css NA 0.2145 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025703 Css NA 1.244 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025703 Css NA 0.1424 mg/L PBTK NA 50% Rat Human +DTXSID8025703 Css NA 0.7886 mg/L PBTK NA 95% Rat Human +DTXSID8025707 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025707 Fup 0.611 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025707 Vd NA 0.897 L/kg 1compartment NA NA Human Human +DTXSID8025707 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8025707 TK.Half.Life NA 9.726 hours 1compartment NA NA Human Human +DTXSID8025707 Css NA 1.151 mg/L 3compartmentss NA 50% Human Human +DTXSID8025707 Css NA 7.99 mg/L 3compartmentss NA 95% Human Human +DTXSID8025707 Css NA 0.9524 mg/L PBTK NA 50% Human Human +DTXSID8025707 Css NA 5.105 mg/L PBTK NA 95% Human Human +DTXSID8025707 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025707 Fup 0.611 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025707 Vd NA 0.8614 L/kg 1compartment NA NA Rat Human DTXSID8025707 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025707 TK.Half.Life NA 0.364 hours 1compartment NA NA Rat Human -DTXSID8025707 Css NA 0.01654 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025707 Css NA 0.117 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025707 Css NA 0.01263 mg/L PBTK NA 50% Rat Human -DTXSID8025707 Css NA 0.07601 mg/L PBTK NA 95% Rat Human -DTXSID8025709 Clint NA 0.000918 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025709 Fup NA 0.0925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025709 Vd NA 7.131 L/kg 1compartment NA NA Human Human -DTXSID8025709 Days.Css NA 13780 Days PBTK NA NA Human Human -DTXSID8025709 TK.Half.Life NA 315600 hours 1compartment NA NA Human Human -DTXSID8025709 Css NA 3376 mg/L 3compartmentss NA 50% Human Human -DTXSID8025709 Css NA 7876 mg/L 3compartmentss NA 95% Human Human -DTXSID8025709 Css NA 3284 mg/L PBTK NA 50% Human Human -DTXSID8025709 Css NA 7025 mg/L PBTK NA 95% Human Human -DTXSID8025709 Clint NA 0.000918 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025709 Fup NA 0.0925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025709 Vd NA 5.53 L/kg 1compartment NA NA Rat Human -DTXSID8025709 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID8025709 TK.Half.Life NA 20670 hours 1compartment NA NA Rat Human -DTXSID8025709 Css NA 969.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025709 Css NA 1514 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025709 Css NA 929.8 mg/L PBTK NA 50% Rat Human -DTXSID8025709 Css NA 1281 mg/L PBTK NA 95% Rat Human +DTXSID8025707 TK.Half.Life NA 3.127 hours 1compartment NA NA Rat Human +DTXSID8025707 Css NA 0.07031 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025707 Css NA 0.4641 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025707 Css NA 0.05823 mg/L PBTK NA 50% Rat Human +DTXSID8025707 Css NA 0.2853 mg/L PBTK NA 95% Rat Human DTXSID8025751 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8025751 Fup NA 0.7638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8025751 Vd NA 0.7272 L/kg 1compartment NA NA Human Human DTXSID8025751 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8025751 TK.Half.Life NA 6.172 hours 1compartment NA NA Human Human -DTXSID8025751 Css NA 1.021 mg/L 3compartmentss NA 50% Human Human -DTXSID8025751 Css NA 6.306 mg/L 3compartmentss NA 95% Human Human -DTXSID8025751 Css NA 0.8395 mg/L PBTK NA 50% Human Human -DTXSID8025751 Css NA 4.049 mg/L PBTK NA 95% Human Human +DTXSID8025751 Css NA 0.8731 mg/L 3compartmentss NA 50% Human Human +DTXSID8025751 Css NA 5.612 mg/L 3compartmentss NA 95% Human Human +DTXSID8025751 Css NA 0.7182 mg/L PBTK NA 50% Human Human +DTXSID8025751 Css NA 3.609 mg/L PBTK NA 95% Human Human DTXSID8025751 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8025751 Fup NA 0.7638 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8025751 Vd NA 0.7479 L/kg 1compartment NA NA Rat Human DTXSID8025751 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8025751 TK.Half.Life NA 2.16 hours 1compartment NA NA Rat Human -DTXSID8025751 Css NA 0.2661 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025751 Css NA 1.638 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025751 Css NA 0.2103 mg/L PBTK NA 50% Rat Human -DTXSID8025751 Css NA 0.9731 mg/L PBTK NA 95% Rat Human -DTXSID8025759 Clint NA 0.6196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025759 Fup NA 0.2769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025759 Vd NA 0.3185 L/kg 1compartment NA NA Human Human +DTXSID8025751 Css NA 0.01638 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025751 Css NA 0.1314 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025751 Css NA 0.01287 mg/L PBTK NA 50% Rat Human +DTXSID8025751 Css NA 0.08435 mg/L PBTK NA 95% Rat Human +DTXSID8025759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025759 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025759 Vd NA 0.3611 L/kg 1compartment NA NA Human Human DTXSID8025759 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025759 TK.Half.Life NA 3.731 hours 1compartment NA NA Human Human -DTXSID8025759 Css NA 1.416 mg/L 3compartmentss NA 50% Human Human -DTXSID8025759 Css NA 5.886 mg/L 3compartmentss NA 95% Human Human -DTXSID8025759 Css NA 0.934 mg/L PBTK NA 50% Human Human -DTXSID8025759 Css NA 3.564 mg/L PBTK NA 95% Human Human -DTXSID8025759 Clint NA 0.6196 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025759 Fup NA 0.2769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025759 Vd NA 0.323 L/kg 1compartment NA NA Rat Human +DTXSID8025759 TK.Half.Life NA 0.4379 hours 1compartment NA NA Human Human +DTXSID8025759 Css NA 0.0557 mg/L 3compartmentss NA 50% Human Human +DTXSID8025759 Css NA 0.4286 mg/L 3compartmentss NA 95% Human Human +DTXSID8025759 Css NA 0.03777 mg/L PBTK NA 50% Human Human +DTXSID8025759 Css NA 0.2738 mg/L PBTK NA 95% Human Human +DTXSID8025759 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025759 Fup 0.379 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025759 Vd NA 0.3678 L/kg 1compartment NA NA Rat Human DTXSID8025759 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025759 TK.Half.Life NA 1.726 hours 1compartment NA NA Rat Human -DTXSID8025759 Css NA 0.5418 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025759 Css NA 1.766 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025759 Css NA 0.3367 mg/L PBTK NA 50% Rat Human -DTXSID8025759 Css NA 1.003 mg/L PBTK NA 95% Rat Human -DTXSID8025886 Clint NA 39.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025886 Fup NA 0.255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025886 Vd NA 1.184 L/kg 1compartment NA NA Human Human +DTXSID8025759 TK.Half.Life NA 0.2288 hours 1compartment NA NA Rat Human +DTXSID8025759 Css NA 0.006911 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025759 Css NA 0.04007 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025759 Css NA 0.004662 mg/L PBTK NA 50% Rat Human +DTXSID8025759 Css NA 0.02506 mg/L PBTK NA 95% Rat Human +DTXSID8025830 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8025830 Fup NA 0.1435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8025830 Vd NA 2.707 L/kg 1compartment NA NA Human Human +DTXSID8025830 Days.Css NA 125 Days PBTK NA NA Human Human +DTXSID8025830 TK.Half.Life NA 526.3 hours 1compartment NA NA Human Human +DTXSID8025830 Css NA 19.94 mg/L 3compartmentss NA 50% Human Human +DTXSID8025830 Css NA 60.61 mg/L 3compartmentss NA 95% Human Human +DTXSID8025830 Css NA 14.05 mg/L PBTK NA 50% Human Human +DTXSID8025830 Css NA 39.86 mg/L PBTK NA 95% Human Human +DTXSID8025830 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8025830 Fup NA 0.1435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8025830 Vd NA 2.044 L/kg 1compartment NA NA Rat Human +DTXSID8025830 Days.Css NA 30 Days PBTK NA NA Rat Human +DTXSID8025830 TK.Half.Life NA 56.22 hours 1compartment NA NA Rat Human +DTXSID8025830 Css NA 0.3472 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025830 Css NA 1.766 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025830 Css NA 0.2349 mg/L PBTK NA 50% Rat Human +DTXSID8025830 Css NA 1.139 mg/L PBTK NA 95% Rat Human +DTXSID8025886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025886 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025886 Vd NA 1.571 L/kg 1compartment NA NA Human Human DTXSID8025886 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025886 TK.Half.Life NA 1.355 hours 1compartment NA NA Human Human -DTXSID8025886 Css NA 0.0498 mg/L 3compartmentss NA 50% Human Human -DTXSID8025886 Css NA 0.3746 mg/L 3compartmentss NA 95% Human Human -DTXSID8025886 Css NA 0.03629 mg/L PBTK NA 50% Human Human -DTXSID8025886 Css NA 0.2547 mg/L PBTK NA 95% Human Human -DTXSID8025886 Clint NA 39.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025886 Fup NA 0.255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025886 Vd NA 0.9751 L/kg 1compartment NA NA Rat Human +DTXSID8025886 TK.Half.Life NA 2.814 hours 1compartment NA NA Human Human +DTXSID8025886 Css NA 0.1241 mg/L 3compartmentss NA 50% Human Human +DTXSID8025886 Css NA 0.8417 mg/L 3compartmentss NA 95% Human Human +DTXSID8025886 Css NA 0.08976 mg/L PBTK NA 50% Human Human +DTXSID8025886 Css NA 0.5639 mg/L PBTK NA 95% Human Human +DTXSID8025886 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025886 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025886 Vd NA 1.236 L/kg 1compartment NA NA Rat Human DTXSID8025886 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025886 TK.Half.Life NA 0.5506 hours 1compartment NA NA Rat Human -DTXSID8025886 Css NA 0.02749 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025886 Css NA 0.1609 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025886 Css NA 0.01922 mg/L PBTK NA 50% Rat Human -DTXSID8025886 Css NA 0.1053 mg/L PBTK NA 95% Rat Human -DTXSID8025888 Clint NA 4.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025888 Fup NA 0.7591 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025888 Vd NA 1.08 L/kg 1compartment NA NA Human Human +DTXSID8025886 TK.Half.Life NA 1.084 hours 1compartment NA NA Rat Human +DTXSID8025886 Css NA 0.01569 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025886 Css NA 0.0804 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025886 Css NA 0.01126 mg/L PBTK NA 50% Rat Human +DTXSID8025886 Css NA 0.05432 mg/L PBTK NA 95% Rat Human +DTXSID8025888 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025888 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025888 Vd NA 0.5883 L/kg 1compartment NA NA Human Human DTXSID8025888 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025888 TK.Half.Life NA 1.671 hours 1compartment NA NA Human Human -DTXSID8025888 Css NA 0.1298 mg/L 3compartmentss NA 50% Human Human -DTXSID8025888 Css NA 1.032 mg/L 3compartmentss NA 95% Human Human -DTXSID8025888 Css NA 0.1133 mg/L PBTK NA 50% Human Human -DTXSID8025888 Css NA 0.7202 mg/L PBTK NA 95% Human Human -DTXSID8025888 Clint NA 4.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025888 Fup NA 0.7591 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025888 Vd NA 1.026 L/kg 1compartment NA NA Rat Human +DTXSID8025888 TK.Half.Life NA 0.9217 hours 1compartment NA NA Human Human +DTXSID8025888 Css NA 0.09692 mg/L 3compartmentss NA 50% Human Human +DTXSID8025888 Css NA 0.6746 mg/L 3compartmentss NA 95% Human Human +DTXSID8025888 Css NA 0.06602 mg/L PBTK NA 50% Human Human +DTXSID8025888 Css NA 0.4414 mg/L PBTK NA 95% Human Human +DTXSID8025888 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025888 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025888 Vd NA 0.5413 L/kg 1compartment NA NA Rat Human DTXSID8025888 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025888 TK.Half.Life NA 0.8373 hours 1compartment NA NA Rat Human -DTXSID8025888 Css NA 0.06018 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025888 Css NA 0.4467 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025888 Css NA 0.05166 mg/L PBTK NA 50% Rat Human -DTXSID8025888 Css NA 0.2792 mg/L PBTK NA 95% Rat Human +DTXSID8025888 TK.Half.Life NA 0.4627 hours 1compartment NA NA Rat Human +DTXSID8025888 Css NA 0.01226 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025888 Css NA 0.06719 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025888 Css NA 0.008314 mg/L PBTK NA 50% Rat Human +DTXSID8025888 Css NA 0.04277 mg/L PBTK NA 95% Rat Human DTXSID8025961 Clint NA 0.003459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8025961 Fup NA 0.4002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8025961 Vd NA 0.3813 L/kg 1compartment NA NA Human Human DTXSID8025961 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8025961 TK.Half.Life NA 6.129 hours 1compartment NA NA Human Human -DTXSID8025961 Css NA 1.899 mg/L 3compartmentss NA 50% Human Human -DTXSID8025961 Css NA 8.338 mg/L 3compartmentss NA 95% Human Human -DTXSID8025961 Css NA 1.327 mg/L PBTK NA 50% Human Human -DTXSID8025961 Css NA 5.13 mg/L PBTK NA 95% Human Human +DTXSID8025961 Css NA 1.616 mg/L 3compartmentss NA 50% Human Human +DTXSID8025961 Css NA 7.161 mg/L 3compartmentss NA 95% Human Human +DTXSID8025961 Css NA 1.127 mg/L PBTK NA 50% Human Human +DTXSID8025961 Css NA 4.456 mg/L PBTK NA 95% Human Human DTXSID8025961 Clint NA 0.003459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8025961 Fup NA 0.4002 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8025961 Vd NA 0.3893 L/kg 1compartment NA NA Rat Human DTXSID8025961 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8025961 TK.Half.Life NA 2.138 hours 1compartment NA NA Rat Human -DTXSID8025961 Css NA 0.5312 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025961 Css NA 1.951 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025961 Css NA 0.3502 mg/L PBTK NA 50% Rat Human -DTXSID8025961 Css NA 1.126 mg/L PBTK NA 95% Rat Human -DTXSID8025963 Clint NA 26.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025963 Fup NA 0.6623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025963 Vd NA 1.227 L/kg 1compartment NA NA Human Human +DTXSID8025961 Css NA 0.02952 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025961 Css NA 0.1875 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025961 Css NA 0.01985 mg/L PBTK NA 50% Rat Human +DTXSID8025961 Css NA 0.1147 mg/L PBTK NA 95% Rat Human +DTXSID8025963 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025963 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025963 Vd NA 0.7162 L/kg 1compartment NA NA Human Human DTXSID8025963 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8025963 TK.Half.Life NA 0.9737 hours 1compartment NA NA Human Human -DTXSID8025963 Css NA 0.02588 mg/L 3compartmentss NA 50% Human Human -DTXSID8025963 Css NA 0.2869 mg/L 3compartmentss NA 95% Human Human -DTXSID8025963 Css NA 0.02232 mg/L PBTK NA 50% Human Human -DTXSID8025963 Css NA 0.2095 mg/L PBTK NA 95% Human Human -DTXSID8025963 Clint NA 26.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025963 Fup NA 0.6623 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025963 Vd NA 1.113 L/kg 1compartment NA NA Rat Human +DTXSID8025963 TK.Half.Life NA 0.8135 hours 1compartment NA NA Human Human +DTXSID8025963 Css NA 0.04072 mg/L 3compartmentss NA 50% Human Human +DTXSID8025963 Css NA 0.3549 mg/L 3compartmentss NA 95% Human Human +DTXSID8025963 Css NA 0.03046 mg/L PBTK NA 50% Human Human +DTXSID8025963 Css NA 0.2361 mg/L PBTK NA 95% Human Human +DTXSID8025963 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025963 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025963 Vd NA 0.6792 L/kg 1compartment NA NA Rat Human DTXSID8025963 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025963 TK.Half.Life NA 0.4232 hours 1compartment NA NA Rat Human -DTXSID8025963 Css NA 0.0132 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025963 Css NA 0.1301 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025963 Css NA 0.01125 mg/L PBTK NA 50% Rat Human -DTXSID8025963 Css NA 0.08551 mg/L PBTK NA 95% Rat Human -DTXSID8025967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025967 Fup NA 0.6554 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8025967 Vd NA 1.212 L/kg 1compartment NA NA Human Human +DTXSID8025963 TK.Half.Life NA 0.3979 hours 1compartment NA NA Rat Human +DTXSID8025963 Css NA 0.001424 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025963 Css NA 0.01407 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025963 Css NA 0.001036 mg/L PBTK NA 50% Rat Human +DTXSID8025963 Css NA 0.009228 mg/L PBTK NA 95% Rat Human +DTXSID8025967 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025967 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8025967 Vd NA 1.108 L/kg 1compartment NA NA Human Human DTXSID8025967 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8025967 TK.Half.Life NA 12.93 hours 1compartment NA NA Human Human -DTXSID8025967 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human -DTXSID8025967 Css NA 7.472 mg/L 3compartmentss NA 95% Human Human -DTXSID8025967 Css NA 0.971 mg/L PBTK NA 50% Human Human -DTXSID8025967 Css NA 4.921 mg/L PBTK NA 95% Human Human -DTXSID8025967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025967 Fup NA 0.6554 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8025967 Vd NA 1.101 L/kg 1compartment NA NA Rat Human +DTXSID8025967 TK.Half.Life NA 10.86 hours 1compartment NA NA Human Human +DTXSID8025967 Css NA 0.8922 mg/L 3compartmentss NA 50% Human Human +DTXSID8025967 Css NA 6.163 mg/L 3compartmentss NA 95% Human Human +DTXSID8025967 Css NA 0.7768 mg/L PBTK NA 50% Human Human +DTXSID8025967 Css NA 4.002 mg/L PBTK NA 95% Human Human +DTXSID8025967 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025967 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8025967 Vd NA 1.034 L/kg 1compartment NA NA Rat Human DTXSID8025967 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8025967 TK.Half.Life NA 3.775 hours 1compartment NA NA Rat Human -DTXSID8025967 Css NA 0.2911 mg/L 3compartmentss NA 50% Rat Human -DTXSID8025967 Css NA 1.863 mg/L 3compartmentss NA 95% Rat Human -DTXSID8025967 Css NA 0.246 mg/L PBTK NA 50% Rat Human -DTXSID8025967 Css NA 1.13 mg/L PBTK NA 95% Rat Human -DTXSID8026018 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026018 Fup NA 0.0603 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026018 Vd NA 0.8932 L/kg 1compartment NA NA Human Human -DTXSID8026018 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID8026018 TK.Half.Life NA 107.6 hours 1compartment NA NA Human Human -DTXSID8026018 Css NA 18.94 mg/L 3compartmentss NA 50% Human Human -DTXSID8026018 Css NA 85.11 mg/L 3compartmentss NA 95% Human Human -DTXSID8026018 Css NA 11.88 mg/L PBTK NA 50% Human Human -DTXSID8026018 Css NA 50.24 mg/L PBTK NA 95% Human Human -DTXSID8026018 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026018 Fup NA 0.0603 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026018 Vd NA 0.6909 L/kg 1compartment NA NA Rat Human -DTXSID8026018 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID8026018 TK.Half.Life NA 26 hours 1compartment NA NA Rat Human -DTXSID8026018 Css NA 5.343 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026018 Css NA 19.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026018 Css NA 3.13 mg/L PBTK NA 50% Rat Human -DTXSID8026018 Css NA 10.7 mg/L PBTK NA 95% Rat Human -DTXSID8026060 Clint NA 3.859 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026060 Fup NA 0.2719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026060 Vd NA 0.2736 L/kg 1compartment NA NA Human Human +DTXSID8025967 TK.Half.Life NA 3.326 hours 1compartment NA NA Rat Human +DTXSID8025967 Css NA 0.01697 mg/L 3compartmentss NA 50% Rat Human +DTXSID8025967 Css NA 0.1414 mg/L 3compartmentss NA 95% Rat Human +DTXSID8025967 Css NA 0.01436 mg/L PBTK NA 50% Rat Human +DTXSID8025967 Css NA 0.09443 mg/L PBTK NA 95% Rat Human +DTXSID8026018 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026018 Fup 0.0977 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026018 Vd NA 1.345 L/kg 1compartment NA NA Human Human +DTXSID8026018 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8026018 TK.Half.Life NA 3.777 hours 1compartment NA NA Human Human +DTXSID8026018 Css NA 0.2686 mg/L 3compartmentss NA 50% Human Human +DTXSID8026018 Css NA 2.149 mg/L 3compartmentss NA 95% Human Human +DTXSID8026018 Css NA 0.1758 mg/L PBTK NA 50% Human Human +DTXSID8026018 Css NA 1.318 mg/L PBTK NA 95% Human Human +DTXSID8026018 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026018 Fup 0.0977 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026018 Vd NA 1.033 L/kg 1compartment NA NA Rat Human +DTXSID8026018 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8026018 TK.Half.Life NA 1.518 hours 1compartment NA NA Rat Human +DTXSID8026018 Css NA 0.01316 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026018 Css NA 0.1184 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026018 Css NA 0.008398 mg/L PBTK NA 50% Rat Human +DTXSID8026018 Css NA 0.07077 mg/L PBTK NA 95% Rat Human +DTXSID8026060 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026060 Fup 0.364 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026060 Vd NA 0.3061 L/kg 1compartment NA NA Human Human DTXSID8026060 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026060 TK.Half.Life NA 1.021 hours 1compartment NA NA Human Human -DTXSID8026060 Css NA 0.4174 mg/L 3compartmentss NA 50% Human Human -DTXSID8026060 Css NA 2.171 mg/L 3compartmentss NA 95% Human Human -DTXSID8026060 Css NA 0.2674 mg/L PBTK NA 50% Human Human -DTXSID8026060 Css NA 1.324 mg/L PBTK NA 95% Human Human -DTXSID8026060 Clint NA 3.859 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026060 Fup NA 0.2719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026060 Vd NA 0.2827 L/kg 1compartment NA NA Rat Human +DTXSID8026060 TK.Half.Life NA 5.441 hours 1compartment NA NA Human Human +DTXSID8026060 Css NA 2.162 mg/L 3compartmentss NA 50% Human Human +DTXSID8026060 Css NA 8.371 mg/L 3compartmentss NA 95% Human Human +DTXSID8026060 Css NA 1.429 mg/L PBTK NA 50% Human Human +DTXSID8026060 Css NA 5.062 mg/L PBTK NA 95% Human Human +DTXSID8026060 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026060 Fup 0.364 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026060 Vd NA 0.3178 L/kg 1compartment NA NA Rat Human DTXSID8026060 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026060 TK.Half.Life NA 0.5996 hours 1compartment NA NA Rat Human -DTXSID8026060 Css NA 0.205 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026060 Css NA 0.8053 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026060 Css NA 0.1236 mg/L PBTK NA 50% Rat Human -DTXSID8026060 Css NA 0.4583 mg/L PBTK NA 95% Rat Human -DTXSID8026064 Clint NA 6.019 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8026060 TK.Half.Life NA 1.925 hours 1compartment NA NA Rat Human +DTXSID8026060 Css NA 0.1381 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026060 Css NA 0.4524 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026060 Css NA 0.08932 mg/L PBTK NA 50% Rat Human +DTXSID8026060 Css NA 0.2663 mg/L PBTK NA 95% Rat Human +DTXSID8026064 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8026064 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8026064 Vd NA 0.3205 L/kg 1compartment NA NA Human Human DTXSID8026064 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026064 TK.Half.Life NA 1.006 hours 1compartment NA NA Human Human -DTXSID8026064 Css NA 0.2788 mg/L 3compartmentss NA 50% Human Human -DTXSID8026064 Css NA 1.688 mg/L 3compartmentss NA 95% Human Human -DTXSID8026064 Css NA 0.2224 mg/L PBTK NA 50% Human Human -DTXSID8026064 Css NA 1.191 mg/L PBTK NA 95% Human Human -DTXSID8026064 Clint NA 6.019 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8026064 TK.Half.Life NA 0.9796 hours 1compartment NA NA Human Human +DTXSID8026064 Css NA 0.2657 mg/L 3compartmentss NA 50% Human Human +DTXSID8026064 Css NA 1.461 mg/L 3compartmentss NA 95% Human Human +DTXSID8026064 Css NA 0.2092 mg/L PBTK NA 50% Human Human +DTXSID8026064 Css NA 1.152 mg/L PBTK NA 95% Human Human +DTXSID8026064 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8026064 Fup 0.23 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8026064 Vd NA 0.3201 L/kg 1compartment NA NA Rat Human DTXSID8026064 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026064 TK.Half.Life NA 0.5924 hours 1compartment NA NA Rat Human -DTXSID8026064 Css NA 0.1415 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026064 Css NA 0.6397 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026064 Css NA 0.1094 mg/L PBTK NA 50% Rat Human -DTXSID8026064 Css NA 0.4186 mg/L PBTK NA 95% Rat Human +DTXSID8026064 TK.Half.Life NA 0.5771 hours 1compartment NA NA Rat Human +DTXSID8026064 Css NA 0.02991 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026064 Css NA 0.1193 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026064 Css NA 0.02447 mg/L PBTK NA 50% Rat Human +DTXSID8026064 Css NA 0.09762 mg/L PBTK NA 95% Rat Human DTXSID8026068 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8026068 Fup NA 0.1753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026068 Vd NA 0.2875 L/kg 1compartment NA NA Human Human +DTXSID8026068 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026068 Vd NA 0.2978 L/kg 1compartment NA NA Human Human DTXSID8026068 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8026068 TK.Half.Life NA 10.62 hours 1compartment NA NA Human Human -DTXSID8026068 Css NA 4.92 mg/L 3compartmentss NA 50% Human Human -DTXSID8026068 Css NA 17.71 mg/L 3compartmentss NA 95% Human Human -DTXSID8026068 Css NA 3.099 mg/L PBTK NA 50% Human Human -DTXSID8026068 Css NA 10.51 mg/L PBTK NA 95% Human Human +DTXSID8026068 TK.Half.Life NA 10.04 hours 1compartment NA NA Human Human +DTXSID8026068 Css NA 4.185 mg/L 3compartmentss NA 50% Human Human +DTXSID8026068 Css NA 15.09 mg/L 3compartmentss NA 95% Human Human +DTXSID8026068 Css NA 2.664 mg/L PBTK NA 50% Human Human +DTXSID8026068 Css NA 9.073 mg/L PBTK NA 95% Human Human DTXSID8026068 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8026068 Fup NA 0.1753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026068 Vd NA 0.2896 L/kg 1compartment NA NA Rat Human +DTXSID8026068 Fup 0.192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026068 Vd NA 0.3002 L/kg 1compartment NA NA Rat Human DTXSID8026068 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026068 TK.Half.Life NA 3.642 hours 1compartment NA NA Rat Human -DTXSID8026068 Css NA 1.364 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026068 Css NA 4.114 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026068 Css NA 0.807 mg/L PBTK NA 50% Rat Human -DTXSID8026068 Css NA 2.297 mg/L PBTK NA 95% Rat Human +DTXSID8026068 TK.Half.Life NA 3.447 hours 1compartment NA NA Rat Human +DTXSID8026068 Css NA 0.272 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026068 Css NA 0.7841 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026068 Css NA 0.1683 mg/L PBTK NA 50% Rat Human +DTXSID8026068 Css NA 0.456 mg/L PBTK NA 95% Rat Human DTXSID8026141 Clint NA 0.02482 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8026141 Fup NA 0.3822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8026141 Vd NA 0.4949 L/kg 1compartment NA NA Human Human DTXSID8026141 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8026141 TK.Half.Life NA 8.024 hours 1compartment NA NA Human Human -DTXSID8026141 Css NA 1.814 mg/L 3compartmentss NA 50% Human Human -DTXSID8026141 Css NA 8.057 mg/L 3compartmentss NA 95% Human Human -DTXSID8026141 Css NA 1.321 mg/L PBTK NA 50% Human Human -DTXSID8026141 Css NA 5.053 mg/L PBTK NA 95% Human Human +DTXSID8026141 Css NA 1.539 mg/L 3compartmentss NA 50% Human Human +DTXSID8026141 Css NA 6.741 mg/L 3compartmentss NA 95% Human Human +DTXSID8026141 Css NA 1.126 mg/L PBTK NA 50% Human Human +DTXSID8026141 Css NA 4.255 mg/L PBTK NA 95% Human Human DTXSID8026141 Clint NA 0.02482 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8026141 Fup NA 0.3822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8026141 Vd NA 0.5088 L/kg 1compartment NA NA Rat Human DTXSID8026141 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8026141 TK.Half.Life NA 2.874 hours 1compartment NA NA Rat Human -DTXSID8026141 Css NA 0.5134 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026141 Css NA 1.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026141 Css NA 0.3558 mg/L PBTK NA 50% Rat Human -DTXSID8026141 Css NA 1.125 mg/L PBTK NA 95% Rat Human -DTXSID8026147 Clint NA 15.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026147 Fup NA 0.2792 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026147 Vd NA 1.384 L/kg 1compartment NA NA Human Human +DTXSID8026141 Css NA 0.02892 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026141 Css NA 0.183 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026141 Css NA 0.02026 mg/L PBTK NA 50% Rat Human +DTXSID8026141 Css NA 0.1159 mg/L PBTK NA 95% Rat Human +DTXSID8026147 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026147 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026147 Vd NA 1.159 L/kg 1compartment NA NA Human Human DTXSID8026147 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026147 TK.Half.Life NA 2.261 hours 1compartment NA NA Human Human -DTXSID8026147 Css NA 0.1114 mg/L 3compartmentss NA 50% Human Human -DTXSID8026147 Css NA 0.7871 mg/L 3compartmentss NA 95% Human Human -DTXSID8026147 Css NA 0.08527 mg/L PBTK NA 50% Human Human -DTXSID8026147 Css NA 0.5505 mg/L PBTK NA 95% Human Human -DTXSID8026147 Clint NA 15.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026147 Fup NA 0.2792 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026147 Vd NA 1.2 L/kg 1compartment NA NA Rat Human +DTXSID8026147 TK.Half.Life NA 1.892 hours 1compartment NA NA Human Human +DTXSID8026147 Css NA 0.1154 mg/L 3compartmentss NA 50% Human Human +DTXSID8026147 Css NA 0.9398 mg/L 3compartmentss NA 95% Human Human +DTXSID8026147 Css NA 0.09654 mg/L PBTK NA 50% Human Human +DTXSID8026147 Css NA 0.649 mg/L PBTK NA 95% Human Human +DTXSID8026147 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026147 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026147 Vd NA 1.112 L/kg 1compartment NA NA Rat Human DTXSID8026147 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026147 TK.Half.Life NA 1.031 hours 1compartment NA NA Rat Human -DTXSID8026147 Css NA 0.0593 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026147 Css NA 0.3142 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026147 Css NA 0.04398 mg/L PBTK NA 50% Rat Human -DTXSID8026147 Css NA 0.2079 mg/L PBTK NA 95% Rat Human -DTXSID8026220 Clint NA 149.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026220 Fup NA 0.1522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026220 Vd NA 0.9473 L/kg 1compartment NA NA Human Human +DTXSID8026147 TK.Half.Life NA 0.9854 hours 1compartment NA NA Rat Human +DTXSID8026147 Css NA 0.01334 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026147 Css NA 0.08869 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026147 Css NA 0.01125 mg/L PBTK NA 50% Rat Human +DTXSID8026147 Css NA 0.05814 mg/L PBTK NA 95% Rat Human +DTXSID8026220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026220 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026220 Vd NA 1.498 L/kg 1compartment NA NA Human Human DTXSID8026220 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026220 TK.Half.Life NA 0.9423 hours 1compartment NA NA Human Human -DTXSID8026220 Css NA 0.02586 mg/L 3compartmentss NA 50% Human Human -DTXSID8026220 Css NA 0.2142 mg/L 3compartmentss NA 95% Human Human -DTXSID8026220 Css NA 0.01731 mg/L PBTK NA 50% Human Human -DTXSID8026220 Css NA 0.1356 mg/L PBTK NA 95% Human Human -DTXSID8026220 Clint NA 149.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026220 Fup NA 0.1522 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026220 Vd NA 0.7713 L/kg 1compartment NA NA Rat Human +DTXSID8026220 TK.Half.Life NA 2.28 hours 1compartment NA NA Human Human +DTXSID8026220 Css NA 0.09303 mg/L 3compartmentss NA 50% Human Human +DTXSID8026220 Css NA 0.6437 mg/L 3compartmentss NA 95% Human Human +DTXSID8026220 Css NA 0.06856 mg/L PBTK NA 50% Human Human +DTXSID8026220 Css NA 0.4437 mg/L PBTK NA 95% Human Human +DTXSID8026220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026220 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026220 Vd NA 1.199 L/kg 1compartment NA NA Rat Human DTXSID8026220 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026220 TK.Half.Life NA 0.361 hours 1compartment NA NA Rat Human -DTXSID8026220 Css NA 0.01477 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026220 Css NA 0.09617 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026220 Css NA 0.0094 mg/L PBTK NA 50% Rat Human -DTXSID8026220 Css NA 0.05728 mg/L PBTK NA 95% Rat Human +DTXSID8026220 TK.Half.Life NA 0.8995 hours 1compartment NA NA Rat Human +DTXSID8026220 Css NA 0.01159 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026220 Css NA 0.0636 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026220 Css NA 0.00859 mg/L PBTK NA 50% Rat Human +DTXSID8026220 Css NA 0.0427 mg/L PBTK NA 95% Rat Human DTXSID8026224 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8026224 Fup 0.66 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8026224 Vd NA 0.7073 L/kg 1compartment NA NA Human Human +DTXSID8026224 Vd NA 0.6639 L/kg 1compartment NA NA Human Human DTXSID8026224 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026224 TK.Half.Life NA 6.956 hours 1compartment NA NA Human Human -DTXSID8026224 Css NA 0.9144 mg/L 3compartmentss NA 50% Human Human -DTXSID8026224 Css NA 2.721 mg/L 3compartmentss NA 95% Human Human -DTXSID8026224 Css NA 0.7657 mg/L PBTK NA 50% Human Human -DTXSID8026224 Css NA 1.98 mg/L PBTK NA 95% Human Human +DTXSID8026224 TK.Half.Life NA 6.521 hours 1compartment NA NA Human Human +DTXSID8026224 Css NA 0.892 mg/L 3compartmentss NA 50% Human Human +DTXSID8026224 Css NA 2.624 mg/L 3compartmentss NA 95% Human Human +DTXSID8026224 Css NA 0.7382 mg/L PBTK NA 50% Human Human +DTXSID8026224 Css NA 1.914 mg/L PBTK NA 95% Human Human DTXSID8026224 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8026224 Fup 0.66 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8026224 Vd NA 0.7202 L/kg 1compartment NA NA Rat Human +DTXSID8026224 Vd NA 0.6841 L/kg 1compartment NA NA Rat Human DTXSID8026224 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026224 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human -DTXSID8026224 Css NA 0.2402 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026224 Css NA 0.5908 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026224 Css NA 0.1968 mg/L PBTK NA 50% Rat Human -DTXSID8026224 Css NA 0.4002 mg/L PBTK NA 95% Rat Human -DTXSID8026228 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026228 Fup NA 0.6316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026228 Vd NA 0.9441 L/kg 1compartment NA NA Human Human +DTXSID8026224 TK.Half.Life NA 2.286 hours 1compartment NA NA Rat Human +DTXSID8026224 Css NA 0.05483 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026224 Css NA 0.1348 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026224 Css NA 0.04588 mg/L PBTK NA 50% Rat Human +DTXSID8026224 Css NA 0.09378 mg/L PBTK NA 95% Rat Human +DTXSID8026228 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026228 Fup 0.6 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026228 Vd NA 0.9158 L/kg 1compartment NA NA Human Human DTXSID8026228 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8026228 TK.Half.Life NA 9.953 hours 1compartment NA NA Human Human -DTXSID8026228 Css NA 1.132 mg/L 3compartmentss NA 50% Human Human -DTXSID8026228 Css NA 7.545 mg/L 3compartmentss NA 95% Human Human -DTXSID8026228 Css NA 0.9553 mg/L PBTK NA 50% Human Human -DTXSID8026228 Css NA 4.843 mg/L PBTK NA 95% Human Human -DTXSID8026228 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026228 Fup NA 0.6316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026228 Vd NA 0.9006 L/kg 1compartment NA NA Rat Human +DTXSID8026228 TK.Half.Life NA 10.15 hours 1compartment NA NA Human Human +DTXSID8026228 Css NA 1.168 mg/L 3compartmentss NA 50% Human Human +DTXSID8026228 Css NA 8.248 mg/L 3compartmentss NA 95% Human Human +DTXSID8026228 Css NA 0.9786 mg/L PBTK NA 50% Human Human +DTXSID8026228 Css NA 5.274 mg/L PBTK NA 95% Human Human +DTXSID8026228 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026228 Fup 0.6 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026228 Vd NA 0.8734 L/kg 1compartment NA NA Rat Human DTXSID8026228 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026228 TK.Half.Life NA 3.165 hours 1compartment NA NA Rat Human -DTXSID8026228 Css NA 0.3012 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026228 Css NA 1.838 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026228 Css NA 0.2443 mg/L PBTK NA 50% Rat Human -DTXSID8026228 Css NA 1.103 mg/L PBTK NA 95% Rat Human -DTXSID8026270 Clint NA 27.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026270 Fup NA 0.2068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026270 Vd NA 0.2714 L/kg 1compartment NA NA Human Human +DTXSID8026228 TK.Half.Life NA 3.23 hours 1compartment NA NA Rat Human +DTXSID8026228 Css NA 0.07118 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026228 Css NA 0.4752 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026228 Css NA 0.05914 mg/L PBTK NA 50% Rat Human +DTXSID8026228 Css NA 0.2919 mg/L PBTK NA 95% Rat Human +DTXSID8026270 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026270 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026270 Vd NA 0.4987 L/kg 1compartment NA NA Human Human DTXSID8026270 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026270 TK.Half.Life NA 0.4109 hours 1compartment NA NA Human Human -DTXSID8026270 Css NA 0.09311 mg/L 3compartmentss NA 50% Human Human -DTXSID8026270 Css NA 0.6152 mg/L 3compartmentss NA 95% Human Human -DTXSID8026270 Css NA 0.0587 mg/L PBTK NA 50% Human Human -DTXSID8026270 Css NA 0.3804 mg/L PBTK NA 95% Human Human -DTXSID8026270 Clint NA 27.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026270 Fup NA 0.2068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026270 Vd NA 0.2757 L/kg 1compartment NA NA Rat Human +DTXSID8026270 TK.Half.Life NA 6.484 hours 1compartment NA NA Human Human +DTXSID8026270 Css NA 1.438 mg/L 3compartmentss NA 50% Human Human +DTXSID8026270 Css NA 7.508 mg/L 3compartmentss NA 95% Human Human +DTXSID8026270 Css NA 1.065 mg/L PBTK NA 50% Human Human +DTXSID8026270 Css NA 4.71 mg/L PBTK NA 95% Human Human +DTXSID8026270 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026270 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026270 Vd NA 0.496 L/kg 1compartment NA NA Rat Human DTXSID8026270 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026270 TK.Half.Life NA 0.2237 hours 1compartment NA NA Rat Human -DTXSID8026270 Css NA 0.05058 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026270 Css NA 0.2696 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026270 Css NA 0.03011 mg/L PBTK NA 50% Rat Human -DTXSID8026270 Css NA 0.1557 mg/L PBTK NA 95% Rat Human +DTXSID8026270 TK.Half.Life NA 2.193 hours 1compartment NA NA Rat Human +DTXSID8026270 Css NA 0.09214 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026270 Css NA 0.3947 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026270 Css NA 0.06706 mg/L PBTK NA 50% Rat Human +DTXSID8026270 Css NA 0.2394 mg/L PBTK NA 95% Rat Human DTXSID8026303 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8026303 Fup 0.0261 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8026303 Vd NA 2.434 L/kg 1compartment NA NA Human Human -DTXSID8026303 Days.Css NA 483 Days PBTK NA NA Human Human -DTXSID8026303 TK.Half.Life NA 1818 hours 1compartment NA NA Human Human -DTXSID8026303 Css NA 91.14 mg/L 3compartmentss NA 50% Human Human -DTXSID8026303 Css NA 285.4 mg/L 3compartmentss NA 95% Human Human -DTXSID8026303 Css NA 60.9 mg/L PBTK NA 50% Human Human -DTXSID8026303 Css NA 177.9 mg/L PBTK NA 95% Human Human +DTXSID8026303 Vd NA 1.631 L/kg 1compartment NA NA Human Human +DTXSID8026303 Days.Css NA 155 Days PBTK NA NA Human Human +DTXSID8026303 TK.Half.Life NA 621.1 hours 1compartment NA NA Human Human +DTXSID8026303 Css NA 46.26 mg/L 3compartmentss NA 50% Human Human +DTXSID8026303 Css NA 178.3 mg/L 3compartmentss NA 95% Human Human +DTXSID8026303 Css NA 29.72 mg/L PBTK NA 50% Human Human +DTXSID8026303 Css NA 107.8 mg/L PBTK NA 95% Human Human DTXSID8026303 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8026303 Fup 0.0261 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8026303 Vd NA 1.817 L/kg 1compartment NA NA Rat Human -DTXSID8026303 Days.Css NA 118 Days PBTK NA NA Rat Human -DTXSID8026303 TK.Half.Life NA 227.1 hours 1compartment NA NA Rat Human -DTXSID8026303 Css NA 24.94 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026303 Css NA 65.53 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026303 Css NA 15.89 mg/L PBTK NA 50% Rat Human -DTXSID8026303 Css NA 38.04 mg/L PBTK NA 95% Rat Human -DTXSID8026305 Clint NA 6.578 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026305 Fup NA 0.4234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026305 Vd NA 1.293 L/kg 1compartment NA NA Human Human +DTXSID8026303 Vd NA 1.212 L/kg 1compartment NA NA Rat Human +DTXSID8026303 Days.Css NA 36 Days PBTK NA NA Rat Human +DTXSID8026303 TK.Half.Life NA 115.4 hours 1compartment NA NA Rat Human +DTXSID8026303 Css NA 2.968 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026303 Css NA 9.813 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026303 Css NA 1.861 mg/L PBTK NA 50% Rat Human +DTXSID8026303 Css NA 5.705 mg/L PBTK NA 95% Rat Human +DTXSID8026305 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026305 Fup 0.417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026305 Vd NA 1.283 L/kg 1compartment NA NA Human Human DTXSID8026305 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026305 TK.Half.Life NA 2.565 hours 1compartment NA NA Human Human -DTXSID8026305 Css NA 0.1564 mg/L 3compartmentss NA 50% Human Human -DTXSID8026305 Css NA 1.051 mg/L 3compartmentss NA 95% Human Human -DTXSID8026305 Css NA 0.1251 mg/L PBTK NA 50% Human Human -DTXSID8026305 Css NA 0.7433 mg/L PBTK NA 95% Human Human -DTXSID8026305 Clint NA 6.578 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026305 Fup NA 0.4234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026305 Vd NA 1.104 L/kg 1compartment NA NA Rat Human +DTXSID8026305 TK.Half.Life NA 1.411 hours 1compartment NA NA Human Human +DTXSID8026305 Css NA 0.04884 mg/L 3compartmentss NA 50% Human Human +DTXSID8026305 Css NA 0.3861 mg/L 3compartmentss NA 95% Human Human +DTXSID8026305 Css NA 0.03887 mg/L PBTK NA 50% Human Human +DTXSID8026305 Css NA 0.2747 mg/L PBTK NA 95% Human Human +DTXSID8026305 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026305 Fup 0.417 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026305 Vd NA 1.095 L/kg 1compartment NA NA Rat Human DTXSID8026305 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026305 TK.Half.Life NA 1.141 hours 1compartment NA NA Rat Human -DTXSID8026305 Css NA 0.07883 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026305 Css NA 0.409 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026305 Css NA 0.06137 mg/L PBTK NA 50% Rat Human -DTXSID8026305 Css NA 0.263 mg/L PBTK NA 95% Rat Human -DTXSID8026307 Clint 8.96 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8026307 Fup 0.4311 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8026307 Vd NA 1.454 L/kg 1compartment NA NA Human Human -DTXSID8026307 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026307 TK.Half.Life NA 2.444 hours 1compartment NA NA Human Human -DTXSID8026307 Css NA 0.1213 mg/L 3compartmentss NA 50% Human Human -DTXSID8026307 Css NA 0.8234 mg/L 3compartmentss NA 95% Human Human -DTXSID8026307 Css NA 0.09716 mg/L PBTK NA 50% Human Human -DTXSID8026307 Css NA 0.5895 mg/L PBTK NA 95% Human Human -DTXSID8026307 Clint 8.96 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8026307 Fup 0.4311 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8026307 Vd NA 1.218 L/kg 1compartment NA NA Rat Human -DTXSID8026307 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026307 TK.Half.Life NA 1.034 hours 1compartment NA NA Rat Human -DTXSID8026307 Css NA 0.06116 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026307 Css NA 0.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026307 Css NA 0.04809 mg/L PBTK NA 50% Rat Human -DTXSID8026307 Css NA 0.2185 mg/L PBTK NA 95% Rat Human -DTXSID8026309 Clint NA 2.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026309 Fup NA 0.4082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026309 Vd NA 1.387 L/kg 1compartment NA NA Human Human +DTXSID8026305 TK.Half.Life NA 0.5975 hours 1compartment NA NA Rat Human +DTXSID8026305 Css NA 0.005906 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026305 Css NA 0.03823 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026305 Css NA 0.004747 mg/L PBTK NA 50% Rat Human +DTXSID8026305 Css NA 0.02678 mg/L PBTK NA 95% Rat Human +DTXSID8026309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026309 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026309 Vd NA 1.404 L/kg 1compartment NA NA Human Human DTXSID8026309 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026309 TK.Half.Life NA 5.541 hours 1compartment NA NA Human Human -DTXSID8026309 Css NA 0.3862 mg/L 3compartmentss NA 50% Human Human -DTXSID8026309 Css NA 2.04 mg/L 3compartmentss NA 95% Human Human -DTXSID8026309 Css NA 0.3112 mg/L PBTK NA 50% Human Human -DTXSID8026309 Css NA 1.423 mg/L PBTK NA 95% Human Human -DTXSID8026309 Clint NA 2.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026309 Fup NA 0.4082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026309 Vd NA 1.167 L/kg 1compartment NA NA Rat Human +DTXSID8026309 TK.Half.Life NA 1.588 hours 1compartment NA NA Human Human +DTXSID8026309 Css NA 0.04205 mg/L 3compartmentss NA 50% Human Human +DTXSID8026309 Css NA 0.3611 mg/L 3compartmentss NA 95% Human Human +DTXSID8026309 Css NA 0.03341 mg/L PBTK NA 50% Human Human +DTXSID8026309 Css NA 0.2551 mg/L PBTK NA 95% Human Human +DTXSID8026309 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026309 Fup 0.406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026309 Vd NA 1.178 L/kg 1compartment NA NA Rat Human DTXSID8026309 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026309 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human -DTXSID8026309 Css NA 0.1761 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026309 Css NA 0.7594 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026309 Css NA 0.1366 mg/L PBTK NA 50% Rat Human -DTXSID8026309 Css NA 0.4772 mg/L PBTK NA 95% Rat Human +DTXSID8026309 TK.Half.Life NA 0.6539 hours 1compartment NA NA Rat Human +DTXSID8026309 Css NA 0.00148 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026309 Css NA 0.01412 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026309 Css NA 0.00116 mg/L PBTK NA 50% Rat Human +DTXSID8026309 Css NA 0.009749 mg/L PBTK NA 95% Rat Human DTXSID8026432 Clint NA 0.01998 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8026432 Fup NA 0.4205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8026432 Vd NA 0.4708 L/kg 1compartment NA NA Human Human DTXSID8026432 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8026432 TK.Half.Life NA 7.015 hours 1compartment NA NA Human Human -DTXSID8026432 Css NA 1.677 mg/L 3compartmentss NA 50% Human Human -DTXSID8026432 Css NA 7.548 mg/L 3compartmentss NA 95% Human Human -DTXSID8026432 Css NA 1.23 mg/L PBTK NA 50% Human Human -DTXSID8026432 Css NA 4.768 mg/L PBTK NA 95% Human Human +DTXSID8026432 Css NA 1.423 mg/L 3compartmentss NA 50% Human Human +DTXSID8026432 Css NA 6.566 mg/L 3compartmentss NA 95% Human Human +DTXSID8026432 Css NA 1.045 mg/L PBTK NA 50% Human Human +DTXSID8026432 Css NA 4.118 mg/L PBTK NA 95% Human Human DTXSID8026432 Clint NA 0.01998 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8026432 Fup NA 0.4205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8026432 Vd NA 0.472 L/kg 1compartment NA NA Rat Human DTXSID8026432 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8026432 TK.Half.Life NA 2.436 hours 1compartment NA NA Rat Human -DTXSID8026432 Css NA 0.468 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026432 Css NA 1.867 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026432 Css NA 0.3274 mg/L PBTK NA 50% Rat Human -DTXSID8026432 Css NA 1.096 mg/L PBTK NA 95% Rat Human +DTXSID8026432 Css NA 0.02645 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026432 Css NA 0.1802 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026432 Css NA 0.0188 mg/L PBTK NA 50% Rat Human +DTXSID8026432 Css NA 0.1123 mg/L PBTK NA 95% Rat Human DTXSID8026436 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8026436 Fup NA 0.91 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026436 Vd NA 0.9073 L/kg 1compartment NA NA Human Human +DTXSID8026436 Vd NA 0.9202 L/kg 1compartment NA NA Human Human DTXSID8026436 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026436 TK.Half.Life NA 0.7442 hours 1compartment NA NA Human Human -DTXSID8026436 Css NA 0.04222 mg/L 3compartmentss NA 50% Human Human -DTXSID8026436 Css NA 0.3799 mg/L 3compartmentss NA 95% Human Human -DTXSID8026436 Css NA 0.03549 mg/L PBTK NA 50% Human Human -DTXSID8026436 Css NA 0.2754 mg/L PBTK NA 95% Human Human +DTXSID8026436 TK.Half.Life NA 0.7537 hours 1compartment NA NA Human Human +DTXSID8026436 Css NA 0.03185 mg/L 3compartmentss NA 50% Human Human +DTXSID8026436 Css NA 0.3456 mg/L 3compartmentss NA 95% Human Human +DTXSID8026436 Css NA 0.02696 mg/L PBTK NA 50% Human Human +DTXSID8026436 Css NA 0.2414 mg/L PBTK NA 95% Human Human DTXSID8026436 Clint NA 13.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8026436 Fup NA 0.91 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026436 Vd NA 0.9162 L/kg 1compartment NA NA Rat Human +DTXSID8026436 Vd NA 0.9265 L/kg 1compartment NA NA Rat Human DTXSID8026436 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026436 TK.Half.Life NA 0.3741 hours 1compartment NA NA Rat Human -DTXSID8026436 Css NA 0.02061 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026436 Css NA 0.1612 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026436 Css NA 0.01728 mg/L PBTK NA 50% Rat Human -DTXSID8026436 Css NA 0.1079 mg/L PBTK NA 95% Rat Human -DTXSID8026513 Clint NA 0.3976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026513 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026513 Vd NA 1.425 L/kg 1compartment NA NA Human Human -DTXSID8026513 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026513 TK.Half.Life NA 6.145 hours 1compartment NA NA Human Human -DTXSID8026513 Css NA 0.4436 mg/L 3compartmentss NA 50% Human Human -DTXSID8026513 Css NA 3.24 mg/L 3compartmentss NA 95% Human Human -DTXSID8026513 Css NA 0.4204 mg/L PBTK NA 50% Human Human -DTXSID8026513 Css NA 2.157 mg/L PBTK NA 95% Human Human -DTXSID8026513 Clint NA 0.3976 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026513 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026513 Vd NA 1.318 L/kg 1compartment NA NA Rat Human +DTXSID8026436 TK.Half.Life NA 0.3779 hours 1compartment NA NA Rat Human +DTXSID8026436 Css NA 0.0011 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026436 Css NA 0.01287 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026436 Css NA 0.0009246 mg/L PBTK NA 50% Rat Human +DTXSID8026436 Css NA 0.009221 mg/L PBTK NA 95% Rat Human +DTXSID8026513 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026513 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026513 Vd NA 0.9514 L/kg 1compartment NA NA Human Human +DTXSID8026513 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8026513 TK.Half.Life NA 11.24 hours 1compartment NA NA Human Human +DTXSID8026513 Css NA 1.238 mg/L 3compartmentss NA 50% Human Human +DTXSID8026513 Css NA 8.719 mg/L 3compartmentss NA 95% Human Human +DTXSID8026513 Css NA 1.02 mg/L PBTK NA 50% Human Human +DTXSID8026513 Css NA 5.591 mg/L PBTK NA 95% Human Human +DTXSID8026513 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026513 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026513 Vd NA 0.8884 L/kg 1compartment NA NA Rat Human DTXSID8026513 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026513 TK.Half.Life NA 2.258 hours 1compartment NA NA Rat Human -DTXSID8026513 Css NA 0.1419 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026513 Css NA 0.984 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026513 Css NA 0.1341 mg/L PBTK NA 50% Rat Human -DTXSID8026513 Css NA 0.6218 mg/L PBTK NA 95% Rat Human -DTXSID8026515 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026515 Fup NA 0.9791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026515 Vd NA 1.348 L/kg 1compartment NA NA Human Human -DTXSID8026515 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026515 TK.Half.Life NA 9.529 hours 1compartment NA NA Human Human -DTXSID8026515 Css NA 0.8004 mg/L 3compartmentss NA 50% Human Human -DTXSID8026515 Css NA 4.882 mg/L 3compartmentss NA 95% Human Human -DTXSID8026515 Css NA 0.7484 mg/L PBTK NA 50% Human Human -DTXSID8026515 Css NA 3.343 mg/L PBTK NA 95% Human Human -DTXSID8026515 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026515 Fup NA 0.9791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026515 Vd NA 1.265 L/kg 1compartment NA NA Rat Human +DTXSID8026513 TK.Half.Life NA 3.474 hours 1compartment NA NA Rat Human +DTXSID8026513 Css NA 0.0757 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026513 Css NA 0.4969 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026513 Css NA 0.0623 mg/L PBTK NA 50% Rat Human +DTXSID8026513 Css NA 0.3048 mg/L PBTK NA 95% Rat Human +DTXSID8026515 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026515 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026515 Vd NA 1.065 L/kg 1compartment NA NA Human Human +DTXSID8026515 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8026515 TK.Half.Life NA 15.71 hours 1compartment NA NA Human Human +DTXSID8026515 Css NA 1.478 mg/L 3compartmentss NA 50% Human Human +DTXSID8026515 Css NA 7.197 mg/L 3compartmentss NA 95% Human Human +DTXSID8026515 Css NA 1.199 mg/L PBTK NA 50% Human Human +DTXSID8026515 Css NA 4.749 mg/L PBTK NA 95% Human Human +DTXSID8026515 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026515 Fup 0.471 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026515 Vd NA 0.9518 L/kg 1compartment NA NA Rat Human DTXSID8026515 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026515 TK.Half.Life NA 2.897 hours 1compartment NA NA Rat Human -DTXSID8026515 Css NA 0.2029 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026515 Css NA 1.197 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026515 Css NA 0.1857 mg/L PBTK NA 50% Rat Human -DTXSID8026515 Css NA 0.7565 mg/L PBTK NA 95% Rat Human -DTXSID8026519 Clint NA 58.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026519 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026519 Vd NA 3.073 L/kg 1compartment NA NA Human Human -DTXSID8026519 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8026519 TK.Half.Life NA 33.05 hours 1compartment NA NA Human Human -DTXSID8026519 Css NA 1.28 mg/L 3compartmentss NA 50% Human Human -DTXSID8026519 Css NA 8.006 mg/L 3compartmentss NA 95% Human Human -DTXSID8026519 Css NA 0.882 mg/L PBTK NA 50% Human Human -DTXSID8026519 Css NA 5.43 mg/L PBTK NA 95% Human Human -DTXSID8026519 Clint NA 58.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026519 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026519 Vd NA 2.301 L/kg 1compartment NA NA Rat Human -DTXSID8026519 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8026519 TK.Half.Life NA 5.041 hours 1compartment NA NA Rat Human -DTXSID8026519 Css NA 0.718 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026519 Css NA 3.627 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026519 Css NA 0.4712 mg/L PBTK NA 50% Rat Human -DTXSID8026519 Css NA 2.335 mg/L PBTK NA 95% Rat Human -DTXSID8026563 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026563 Fup NA 0.0309 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026563 Vd NA 2.795 L/kg 1compartment NA NA Human Human -DTXSID8026563 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID8026563 TK.Half.Life NA 3461 hours 1compartment NA NA Human Human -DTXSID8026563 Css NA 158.5 mg/L 3compartmentss NA 50% Human Human -DTXSID8026563 Css NA 499.7 mg/L 3compartmentss NA 95% Human Human -DTXSID8026563 Css NA 107.5 mg/L PBTK NA 50% Human Human -DTXSID8026563 Css NA 316.5 mg/L PBTK NA 95% Human Human -DTXSID8026563 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026563 Fup NA 0.0309 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026563 Vd NA 2.092 L/kg 1compartment NA NA Rat Human -DTXSID8026563 Days.Css NA 234 Days PBTK NA NA Rat Human -DTXSID8026563 TK.Half.Life NA 324.1 hours 1compartment NA NA Rat Human -DTXSID8026563 Css NA 43.18 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026563 Css NA 112.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026563 Css NA 27.9 mg/L PBTK NA 50% Rat Human -DTXSID8026563 Css NA 65.68 mg/L PBTK NA 95% Rat Human -DTXSID8026698 Clint NA 16.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026698 Fup NA 0.7041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026698 Vd NA 0.8392 L/kg 1compartment NA NA Human Human -DTXSID8026698 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026698 TK.Half.Life NA 0.7523 hours 1compartment NA NA Human Human -DTXSID8026698 Css NA 0.04074 mg/L 3compartmentss NA 50% Human Human -DTXSID8026698 Css NA 0.4154 mg/L 3compartmentss NA 95% Human Human -DTXSID8026698 Css NA 0.03381 mg/L PBTK NA 50% Human Human -DTXSID8026698 Css NA 0.2845 mg/L PBTK NA 95% Human Human -DTXSID8026698 Clint NA 16.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026698 Fup NA 0.7041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026698 Vd NA 0.8332 L/kg 1compartment NA NA Rat Human -DTXSID8026698 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026698 TK.Half.Life NA 0.3741 hours 1compartment NA NA Rat Human -DTXSID8026698 Css NA 0.02076 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026698 Css NA 0.1869 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026698 Css NA 0.01682 mg/L PBTK NA 50% Rat Human -DTXSID8026698 Css NA 0.1188 mg/L PBTK NA 95% Rat Human -DTXSID8026725 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026725 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026725 Vd NA 8.608 L/kg 1compartment NA NA Human Human -DTXSID8026725 Days.Css NA 2299 Days PBTK NA NA Human Human -DTXSID8026725 TK.Half.Life NA 8411 hours 1compartment NA NA Human Human -DTXSID8026725 Css NA 87.65 mg/L 3compartmentss NA 50% Human Human -DTXSID8026725 Css NA 516.7 mg/L 3compartmentss NA 95% Human Human -DTXSID8026725 Css NA 91.68 mg/L PBTK NA 50% Human Human -DTXSID8026725 Css NA 377.7 mg/L PBTK NA 95% Human Human -DTXSID8026725 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026725 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026725 Vd NA 6.752 L/kg 1compartment NA NA Rat Human -DTXSID8026725 Days.Css NA 612 Days PBTK NA NA Rat Human -DTXSID8026725 TK.Half.Life NA 1363 hours 1compartment NA NA Rat Human -DTXSID8026725 Css NA 23.15 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026725 Css NA 121.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026725 Css NA 23.98 mg/L PBTK NA 50% Rat Human -DTXSID8026725 Css NA 83.05 mg/L PBTK NA 95% Rat Human -DTXSID8026727 Clint NA 33.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026727 Fup NA 0.2206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026727 Vd NA 2.895 L/kg 1compartment NA NA Human Human +DTXSID8026515 TK.Half.Life NA 4.533 hours 1compartment NA NA Rat Human +DTXSID8026515 Css NA 0.09338 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026515 Css NA 0.4027 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026515 Css NA 0.07551 mg/L PBTK NA 50% Rat Human +DTXSID8026515 Css NA 0.2551 mg/L PBTK NA 95% Rat Human +DTXSID8026519 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026519 Fup 0.0175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026519 Vd NA 3.117 L/kg 1compartment NA NA Human Human +DTXSID8026519 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID8026519 TK.Half.Life NA 91.86 hours 1compartment NA NA Human Human +DTXSID8026519 Css NA 3.473 mg/L 3compartmentss NA 50% Human Human +DTXSID8026519 Css NA 20.66 mg/L 3compartmentss NA 95% Human Human +DTXSID8026519 Css NA 2.415 mg/L PBTK NA 50% Human Human +DTXSID8026519 Css NA 14.22 mg/L PBTK NA 95% Human Human +DTXSID8026519 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026519 Fup 0.0175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026519 Vd NA 2.335 L/kg 1compartment NA NA Rat Human +DTXSID8026519 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID8026519 TK.Half.Life NA 12.39 hours 1compartment NA NA Rat Human +DTXSID8026519 Css NA 0.452 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026519 Css NA 2.222 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026519 Css NA 0.3096 mg/L PBTK NA 50% Rat Human +DTXSID8026519 Css NA 1.5 mg/L PBTK NA 95% Rat Human +DTXSID8026563 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026563 Fup 0.0125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026563 Vd NA 3.116 L/kg 1compartment NA NA Human Human +DTXSID8026563 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID8026563 TK.Half.Life NA 94.32 hours 1compartment NA NA Human Human +DTXSID8026563 Css NA 3.44 mg/L 3compartmentss NA 50% Human Human +DTXSID8026563 Css NA 19.23 mg/L 3compartmentss NA 95% Human Human +DTXSID8026563 Css NA 2.401 mg/L PBTK NA 50% Human Human +DTXSID8026563 Css NA 13.37 mg/L PBTK NA 95% Human Human +DTXSID8026563 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026563 Fup 0.0125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026563 Vd NA 2.334 L/kg 1compartment NA NA Rat Human +DTXSID8026563 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID8026563 TK.Half.Life NA 12.73 hours 1compartment NA NA Rat Human +DTXSID8026563 Css NA 0.4516 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026563 Css NA 2.219 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026563 Css NA 0.3087 mg/L PBTK NA 50% Rat Human +DTXSID8026563 Css NA 1.591 mg/L PBTK NA 95% Rat Human +DTXSID8026698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026698 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026698 Vd NA 1.946 L/kg 1compartment NA NA Human Human +DTXSID8026698 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID8026698 TK.Half.Life NA 86.97 hours 1compartment NA NA Human Human +DTXSID8026698 Css NA 4.781 mg/L 3compartmentss NA 50% Human Human +DTXSID8026698 Css NA 15.71 mg/L 3compartmentss NA 95% Human Human +DTXSID8026698 Css NA 3.555 mg/L PBTK NA 50% Human Human +DTXSID8026698 Css NA 10.23 mg/L PBTK NA 95% Human Human +DTXSID8026698 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026698 Fup 0.242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026698 Vd NA 1.515 L/kg 1compartment NA NA Rat Human +DTXSID8026698 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8026698 TK.Half.Life NA 16.01 hours 1compartment NA NA Rat Human +DTXSID8026698 Css NA 0.3014 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026698 Css NA 0.8419 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026698 Css NA 0.2228 mg/L PBTK NA 50% Rat Human +DTXSID8026698 Css NA 0.5341 mg/L PBTK NA 95% Rat Human +DTXSID8026725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026725 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026725 Vd NA 1.57 L/kg 1compartment NA NA Human Human +DTXSID8026725 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8026725 TK.Half.Life NA 18.93 hours 1compartment NA NA Human Human +DTXSID8026725 Css NA 1.878 mg/L 3compartmentss NA 50% Human Human +DTXSID8026725 Css NA 17.1 mg/L 3compartmentss NA 95% Human Human +DTXSID8026725 Css NA 1.191 mg/L PBTK NA 50% Human Human +DTXSID8026725 Css NA 10.38 mg/L PBTK NA 95% Human Human +DTXSID8026725 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026725 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026725 Vd NA 1.169 L/kg 1compartment NA NA Rat Human +DTXSID8026725 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8026725 TK.Half.Life NA 7.196 hours 1compartment NA NA Rat Human +DTXSID8026725 Css NA 0.2422 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026725 Css NA 1.808 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026725 Css NA 0.1503 mg/L PBTK NA 50% Rat Human +DTXSID8026725 Css NA 1.063 mg/L PBTK NA 95% Rat Human +DTXSID8026727 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026727 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026727 Vd NA 2.797 L/kg 1compartment NA NA Human Human DTXSID8026727 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026727 TK.Half.Life NA 8.774 hours 1compartment NA NA Human Human -DTXSID8026727 Css NA 0.2748 mg/L 3compartmentss NA 50% Human Human -DTXSID8026727 Css NA 1.659 mg/L 3compartmentss NA 95% Human Human -DTXSID8026727 Css NA 0.197 mg/L PBTK NA 50% Human Human -DTXSID8026727 Css NA 1.151 mg/L PBTK NA 95% Human Human -DTXSID8026727 Clint NA 33.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026727 Fup NA 0.2206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026727 Vd NA 2.189 L/kg 1compartment NA NA Rat Human +DTXSID8026727 TK.Half.Life NA 12.33 hours 1compartment NA NA Human Human +DTXSID8026727 Css NA 0.4485 mg/L 3compartmentss NA 50% Human Human +DTXSID8026727 Css NA 2.798 mg/L 3compartmentss NA 95% Human Human +DTXSID8026727 Css NA 0.3194 mg/L PBTK NA 50% Human Human +DTXSID8026727 Css NA 1.885 mg/L PBTK NA 95% Human Human +DTXSID8026727 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026727 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026727 Vd NA 2.111 L/kg 1compartment NA NA Rat Human DTXSID8026727 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026727 TK.Half.Life NA 1.914 hours 1compartment NA NA Rat Human -DTXSID8026727 Css NA 0.1525 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026727 Css NA 0.7519 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026727 Css NA 0.1053 mg/L PBTK NA 50% Rat Human -DTXSID8026727 Css NA 0.5033 mg/L PBTK NA 95% Rat Human -DTXSID8026773 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026773 Fup NA 0.9553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026773 Vd NA 0.8267 L/kg 1compartment NA NA Human Human +DTXSID8026727 TK.Half.Life NA 2.71 hours 1compartment NA NA Rat Human +DTXSID8026727 Css NA 0.05682 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026727 Css NA 0.2836 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026727 Css NA 0.04008 mg/L PBTK NA 50% Rat Human +DTXSID8026727 Css NA 0.1968 mg/L PBTK NA 95% Rat Human +DTXSID8026729 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026729 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026729 Vd NA 1.124 L/kg 1compartment NA NA Human Human +DTXSID8026729 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8026729 TK.Half.Life NA 1.149 hours 1compartment NA NA Human Human +DTXSID8026729 Css NA 0.04111 mg/L 3compartmentss NA 50% Human Human +DTXSID8026729 Css NA 0.3624 mg/L 3compartmentss NA 95% Human Human +DTXSID8026729 Css NA 0.03328 mg/L PBTK NA 50% Human Human +DTXSID8026729 Css NA 0.2565 mg/L PBTK NA 95% Human Human +DTXSID8026729 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026729 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026729 Vd NA 0.9931 L/kg 1compartment NA NA Rat Human +DTXSID8026729 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8026729 TK.Half.Life NA 0.5063 hours 1compartment NA NA Rat Human +DTXSID8026729 Css NA 0.005103 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026729 Css NA 0.0342 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026729 Css NA 0.004164 mg/L PBTK NA 50% Rat Human +DTXSID8026729 Css NA 0.02401 mg/L PBTK NA 95% Rat Human +DTXSID8026773 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026773 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026773 Vd NA 0.5852 L/kg 1compartment NA NA Human Human DTXSID8026773 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026773 TK.Half.Life NA 5.613 hours 1compartment NA NA Human Human -DTXSID8026773 Css NA 0.833 mg/L 3compartmentss NA 50% Human Human -DTXSID8026773 Css NA 2.99 mg/L 3compartmentss NA 95% Human Human -DTXSID8026773 Css NA 0.71 mg/L PBTK NA 50% Human Human -DTXSID8026773 Css NA 2.134 mg/L PBTK NA 95% Human Human -DTXSID8026773 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026773 Fup NA 0.9553 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026773 Vd NA 0.8539 L/kg 1compartment NA NA Rat Human +DTXSID8026773 TK.Half.Life NA 6.406 hours 1compartment NA NA Human Human +DTXSID8026773 Css NA 1.088 mg/L 3compartmentss NA 50% Human Human +DTXSID8026773 Css NA 7.469 mg/L 3compartmentss NA 95% Human Human +DTXSID8026773 Css NA 0.8476 mg/L PBTK NA 50% Human Human +DTXSID8026773 Css NA 4.65 mg/L PBTK NA 95% Human Human +DTXSID8026773 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026773 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026773 Vd NA 0.6093 L/kg 1compartment NA NA Rat Human DTXSID8026773 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026773 TK.Half.Life NA 1.971 hours 1compartment NA NA Rat Human -DTXSID8026773 Css NA 0.2158 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026773 Css NA 0.6883 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026773 Css NA 0.1796 mg/L PBTK NA 50% Rat Human -DTXSID8026773 Css NA 0.4517 mg/L PBTK NA 95% Rat Human -DTXSID8026775 Clint NA 0.0006303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026775 Fup NA 0.4333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026775 Vd NA 0.4043 L/kg 1compartment NA NA Human Human +DTXSID8026773 TK.Half.Life NA 2.273 hours 1compartment NA NA Rat Human +DTXSID8026773 Css NA 0.02082 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026773 Css NA 0.1812 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026773 Css NA 0.01555 mg/L PBTK NA 50% Rat Human +DTXSID8026773 Css NA 0.1106 mg/L PBTK NA 95% Rat Human +DTXSID8026775 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026775 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026775 Vd NA 0.4713 L/kg 1compartment NA NA Human Human DTXSID8026775 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026775 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human -DTXSID8026775 Css NA 1.757 mg/L 3compartmentss NA 50% Human Human -DTXSID8026775 Css NA 7.948 mg/L 3compartmentss NA 95% Human Human -DTXSID8026775 Css NA 1.237 mg/L PBTK NA 50% Human Human -DTXSID8026775 Css NA 4.955 mg/L PBTK NA 95% Human Human -DTXSID8026775 Clint NA 0.0006303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026775 Fup NA 0.4333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026775 Vd NA 0.4125 L/kg 1compartment NA NA Rat Human +DTXSID8026775 TK.Half.Life NA 5.212 hours 1compartment NA NA Human Human +DTXSID8026775 Css NA 1.155 mg/L 3compartmentss NA 50% Human Human +DTXSID8026775 Css NA 7.556 mg/L 3compartmentss NA 95% Human Human +DTXSID8026775 Css NA 0.86 mg/L PBTK NA 50% Human Human +DTXSID8026775 Css NA 4.685 mg/L PBTK NA 95% Human Human +DTXSID8026775 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026775 Fup 0.585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026775 Vd NA 0.4821 L/kg 1compartment NA NA Rat Human DTXSID8026775 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026775 TK.Half.Life NA 2.098 hours 1compartment NA NA Rat Human -DTXSID8026775 Css NA 0.4854 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026775 Css NA 1.858 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026775 Css NA 0.3261 mg/L PBTK NA 50% Rat Human -DTXSID8026775 Css NA 1.077 mg/L PBTK NA 95% Rat Human -DTXSID8026931 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026931 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026931 Vd NA 82.36 L/kg 1compartment NA NA Human Human -DTXSID8026931 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8026931 TK.Half.Life NA 172100 hours 1compartment NA NA Human Human -DTXSID8026931 Css NA 26.65 mg/L 3compartmentss NA 50% Human Human -DTXSID8026931 Css NA 315.5 mg/L 3compartmentss NA 95% Human Human -DTXSID8026931 Css NA 209.4 mg/L PBTK NA 50% Human Human -DTXSID8026931 Css NA 878.9 mg/L PBTK NA 95% Human Human -DTXSID8026931 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026931 Fup NA 0.0038 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026931 Vd NA 70.77 L/kg 1compartment NA NA Rat Human -DTXSID8026931 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID8026931 TK.Half.Life NA 43290 hours 1compartment NA NA Rat Human -DTXSID8026931 Css NA 6.482 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026931 Css NA 68.27 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026931 Css NA 55.28 mg/L PBTK NA 50% Rat Human -DTXSID8026931 Css NA 193 mg/L PBTK NA 95% Rat Human -DTXSID8026933 Clint NA 84.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026933 Fup NA 0.0347 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026933 Vd NA 16.47 L/kg 1compartment NA NA Human Human -DTXSID8026933 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026933 TK.Half.Life NA 4.173 hours 1compartment NA NA Human Human -DTXSID8026933 Css NA 0.002064 mg/L 3compartmentss NA 50% Human Human -DTXSID8026933 Css NA 0.02554 mg/L 3compartmentss NA 95% Human Human -DTXSID8026933 Css NA 0.004206 mg/L PBTK NA 50% Human Human -DTXSID8026933 Css NA 0.03315 mg/L PBTK NA 95% Human Human -DTXSID8026933 Clint NA 84.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026933 Fup NA 0.0347 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026933 Vd NA 13.84 L/kg 1compartment NA NA Rat Human -DTXSID8026933 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026933 TK.Half.Life NA 1.614 hours 1compartment NA NA Rat Human -DTXSID8026933 Css NA 0.00108 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026933 Css NA 0.01149 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026933 Css NA 0.002297 mg/L PBTK NA 50% Rat Human -DTXSID8026933 Css NA 0.01445 mg/L PBTK NA 95% Rat Human -DTXSID8026935 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026935 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026935 Vd NA 81.91 L/kg 1compartment NA NA Human Human -DTXSID8026935 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID8026935 TK.Half.Life NA 3916000 hours 1compartment NA NA Human Human -DTXSID8026935 Css NA 383.8 mg/L 3compartmentss NA 50% Human Human -DTXSID8026935 Css NA 1011 mg/L 3compartmentss NA 95% Human Human -DTXSID8026935 Css NA 3699 mg/L PBTK NA 50% Human Human -DTXSID8026935 Css NA 7983 mg/L PBTK NA 95% Human Human -DTXSID8026935 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026935 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026935 Vd NA 70.32 L/kg 1compartment NA NA Rat Human -DTXSID8026935 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID8026935 TK.Half.Life NA 284900 hours 1compartment NA NA Rat Human -DTXSID8026935 Css NA 94.19 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026935 Css NA 165 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026935 Css NA 992.8 mg/L PBTK NA 50% Rat Human -DTXSID8026935 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID8026981 Clint NA 3.233 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026981 Fup NA 0.2361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8026981 Vd NA 0.3573 L/kg 1compartment NA NA Human Human +DTXSID8026775 TK.Half.Life NA 1.817 hours 1compartment NA NA Rat Human +DTXSID8026775 Css NA 0.0217 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026775 Css NA 0.1896 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026775 Css NA 0.01545 mg/L PBTK NA 50% Rat Human +DTXSID8026775 Css NA 0.1152 mg/L PBTK NA 95% Rat Human +DTXSID8026981 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026981 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8026981 Vd NA 0.3345 L/kg 1compartment NA NA Human Human DTXSID8026981 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8026981 TK.Half.Life NA 1.755 hours 1compartment NA NA Human Human -DTXSID8026981 Css NA 0.5568 mg/L 3compartmentss NA 50% Human Human -DTXSID8026981 Css NA 2.807 mg/L 3compartmentss NA 95% Human Human -DTXSID8026981 Css NA 0.3694 mg/L PBTK NA 50% Human Human -DTXSID8026981 Css NA 1.753 mg/L PBTK NA 95% Human Human -DTXSID8026981 Clint NA 3.233 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026981 Fup NA 0.2361 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8026981 Vd NA 0.3521 L/kg 1compartment NA NA Rat Human +DTXSID8026981 TK.Half.Life NA 1.184 hours 1compartment NA NA Human Human +DTXSID8026981 Css NA 0.3643 mg/L 3compartmentss NA 50% Human Human +DTXSID8026981 Css NA 2.093 mg/L 3compartmentss NA 95% Human Human +DTXSID8026981 Css NA 0.2364 mg/L PBTK NA 50% Human Human +DTXSID8026981 Css NA 1.301 mg/L PBTK NA 95% Human Human +DTXSID8026981 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026981 Fup 0.202 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8026981 Vd NA 0.3293 L/kg 1compartment NA NA Rat Human DTXSID8026981 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8026981 TK.Half.Life NA 0.9814 hours 1compartment NA NA Rat Human -DTXSID8026981 Css NA 0.2716 mg/L 3compartmentss NA 50% Rat Human -DTXSID8026981 Css NA 1.032 mg/L 3compartmentss NA 95% Rat Human -DTXSID8026981 Css NA 0.1698 mg/L PBTK NA 50% Rat Human -DTXSID8026981 Css NA 0.593 mg/L PBTK NA 95% Rat Human +DTXSID8026981 TK.Half.Life NA 0.6829 hours 1compartment NA NA Rat Human +DTXSID8026981 Css NA 0.04358 mg/L 3compartmentss NA 50% Rat Human +DTXSID8026981 Css NA 0.1817 mg/L 3compartmentss NA 95% Rat Human +DTXSID8026981 Css NA 0.02761 mg/L PBTK NA 50% Rat Human +DTXSID8026981 Css NA 0.1091 mg/L PBTK NA 95% Rat Human DTXSID8027032 Clint NA 0.08986 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8027032 Fup NA 0.8622 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027032 Vd NA 1.627 L/kg 1compartment NA NA Human Human +DTXSID8027032 Vd NA 1.763 L/kg 1compartment NA NA Human Human DTXSID8027032 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8027032 TK.Half.Life NA 10.64 hours 1compartment NA NA Human Human -DTXSID8027032 Css NA 0.6883 mg/L 3compartmentss NA 50% Human Human -DTXSID8027032 Css NA 4.453 mg/L 3compartmentss NA 95% Human Human -DTXSID8027032 Css NA 0.6678 mg/L PBTK NA 50% Human Human -DTXSID8027032 Css NA 3.09 mg/L PBTK NA 95% Human Human +DTXSID8027032 TK.Half.Life NA 11.53 hours 1compartment NA NA Human Human +DTXSID8027032 Css NA 0.5696 mg/L 3compartmentss NA 50% Human Human +DTXSID8027032 Css NA 3.952 mg/L 3compartmentss NA 95% Human Human +DTXSID8027032 Css NA 0.5672 mg/L PBTK NA 50% Human Human +DTXSID8027032 Css NA 2.745 mg/L PBTK NA 95% Human Human DTXSID8027032 Clint NA 0.08986 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8027032 Fup NA 0.8622 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027032 Vd NA 1.651 L/kg 1compartment NA NA Rat Human +DTXSID8027032 Vd NA 1.784 L/kg 1compartment NA NA Rat Human DTXSID8027032 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027032 TK.Half.Life NA 3.938 hours 1compartment NA NA Rat Human -DTXSID8027032 Css NA 0.1874 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027032 Css NA 1.213 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027032 Css NA 0.1803 mg/L PBTK NA 50% Rat Human -DTXSID8027032 Css NA 0.7746 mg/L PBTK NA 95% Rat Human +DTXSID8027032 TK.Half.Life NA 4.258 hours 1compartment NA NA Rat Human +DTXSID8027032 Css NA 0.01171 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027032 Css NA 0.09049 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027032 Css NA 0.01132 mg/L PBTK NA 50% Rat Human +DTXSID8027032 Css NA 0.06765 mg/L PBTK NA 95% Rat Human DTXSID8027034 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8027034 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027034 Vd NA 0.7249 L/kg 1compartment NA NA Human Human +DTXSID8027034 Vd NA 1.387 L/kg 1compartment NA NA Human Human DTXSID8027034 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027034 TK.Half.Life NA 4.693 hours 1compartment NA NA Human Human -DTXSID8027034 Css NA 0.8421 mg/L 3compartmentss NA 50% Human Human -DTXSID8027034 Css NA 5.535 mg/L 3compartmentss NA 95% Human Human -DTXSID8027034 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID8027034 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID8027034 TK.Half.Life NA 9.682 hours 1compartment NA NA Human Human +DTXSID8027034 Css NA 0.6352 mg/L 3compartmentss NA 50% Human Human +DTXSID8027034 Css NA 4.73 mg/L 3compartmentss NA 95% Human Human +DTXSID8027034 Css NA 0.603 mg/L PBTK NA 50% Human Human +DTXSID8027034 Css NA 3.222 mg/L PBTK NA 95% Human Human DTXSID8027034 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8027034 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027034 Vd NA 0.7688 L/kg 1compartment NA NA Rat Human +DTXSID8027034 Vd NA 1.294 L/kg 1compartment NA NA Rat Human DTXSID8027034 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027034 TK.Half.Life NA 1.695 hours 1compartment NA NA Rat Human -DTXSID8027034 Css NA 0.2116 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027034 Css NA 1.314 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027034 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID8027034 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID8027036 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027036 Fup NA 0.9624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027036 Vd NA 0.8591 L/kg 1compartment NA NA Human Human +DTXSID8027034 TK.Half.Life NA 2.906 hours 1compartment NA NA Rat Human +DTXSID8027034 Css NA 0.01145 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027034 Css NA 0.09749 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027034 Css NA 0.01057 mg/L PBTK NA 50% Rat Human +DTXSID8027034 Css NA 0.06687 mg/L PBTK NA 95% Rat Human +DTXSID8027036 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027036 Fup 0.764 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027036 Vd NA 0.8275 L/kg 1compartment NA NA Human Human DTXSID8027036 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027036 TK.Half.Life NA 5.791 hours 1compartment NA NA Human Human -DTXSID8027036 Css NA 0.87 mg/L 3compartmentss NA 50% Human Human -DTXSID8027036 Css NA 5.028 mg/L 3compartmentss NA 95% Human Human -DTXSID8027036 Css NA 0.741 mg/L PBTK NA 50% Human Human -DTXSID8027036 Css NA 3.3 mg/L PBTK NA 95% Human Human -DTXSID8027036 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027036 Fup NA 0.9624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027036 Vd NA 0.8819 L/kg 1compartment NA NA Rat Human +DTXSID8027036 TK.Half.Life NA 7.059 hours 1compartment NA NA Human Human +DTXSID8027036 Css NA 0.8433 mg/L 3compartmentss NA 50% Human Human +DTXSID8027036 Css NA 5.632 mg/L 3compartmentss NA 95% Human Human +DTXSID8027036 Css NA 0.7112 mg/L PBTK NA 50% Human Human +DTXSID8027036 Css NA 3.644 mg/L PBTK NA 95% Human Human +DTXSID8027036 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027036 Fup 0.764 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027036 Vd NA 0.8325 L/kg 1compartment NA NA Rat Human DTXSID8027036 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027036 TK.Half.Life NA 2.022 hours 1compartment NA NA Rat Human -DTXSID8027036 Css NA 0.2204 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027036 Css NA 1.173 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027036 Css NA 0.1836 mg/L PBTK NA 50% Rat Human -DTXSID8027036 Css NA 0.7211 mg/L PBTK NA 95% Rat Human -DTXSID8027084 Clint NA 0.7305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027084 Fup NA 0.3506 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027084 Vd NA 0.5854 L/kg 1compartment NA NA Human Human +DTXSID8027036 TK.Half.Life NA 2.407 hours 1compartment NA NA Rat Human +DTXSID8027036 Css NA 0.01614 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027036 Css NA 0.126 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027036 Css NA 0.01309 mg/L PBTK NA 50% Rat Human +DTXSID8027036 Css NA 0.08171 mg/L PBTK NA 95% Rat Human +DTXSID8027084 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027084 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027084 Vd NA 0.4594 L/kg 1compartment NA NA Human Human DTXSID8027084 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027084 TK.Half.Life NA 5.045 hours 1compartment NA NA Human Human -DTXSID8027084 Css NA 0.9482 mg/L 3compartmentss NA 50% Human Human -DTXSID8027084 Css NA 4.34 mg/L 3compartmentss NA 95% Human Human -DTXSID8027084 Css NA 0.6904 mg/L PBTK NA 50% Human Human -DTXSID8027084 Css NA 2.756 mg/L PBTK NA 95% Human Human -DTXSID8027084 Clint NA 0.7305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027084 Fup NA 0.3506 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027084 Vd NA 0.5706 L/kg 1compartment NA NA Rat Human +DTXSID8027084 TK.Half.Life NA 6.995 hours 1compartment NA NA Human Human +DTXSID8027084 Css NA 1.711 mg/L 3compartmentss NA 50% Human Human +DTXSID8027084 Css NA 7.551 mg/L 3compartmentss NA 95% Human Human +DTXSID8027084 Css NA 1.221 mg/L PBTK NA 50% Human Human +DTXSID8027084 Css NA 4.73 mg/L PBTK NA 95% Human Human +DTXSID8027084 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027084 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027084 Vd NA 0.481 L/kg 1compartment NA NA Rat Human DTXSID8027084 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027084 TK.Half.Life NA 2.286 hours 1compartment NA NA Rat Human -DTXSID8027084 Css NA 0.3618 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027084 Css NA 1.374 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027084 Css NA 0.2516 mg/L PBTK NA 50% Rat Human -DTXSID8027084 Css NA 0.8113 mg/L PBTK NA 95% Rat Human -DTXSID8027086 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027086 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027086 Vd NA 7.206 L/kg 1compartment NA NA Human Human -DTXSID8027086 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8027086 TK.Half.Life NA 318400 hours 1compartment NA NA Human Human -DTXSID8027086 Css NA 3539 mg/L 3compartmentss NA 50% Human Human -DTXSID8027086 Css NA 8510 mg/L 3compartmentss NA 95% Human Human -DTXSID8027086 Css NA 3434 mg/L PBTK NA 50% Human Human -DTXSID8027086 Css NA 7550 mg/L PBTK NA 95% Human Human -DTXSID8027086 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027086 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027086 Vd NA 5.591 L/kg 1compartment NA NA Rat Human -DTXSID8027086 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID8027086 TK.Half.Life NA 20680 hours 1compartment NA NA Rat Human -DTXSID8027086 Css NA 949.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027086 Css NA 1596 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027086 Css NA 913.1 mg/L PBTK NA 50% Rat Human -DTXSID8027086 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID8027113 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027113 Fup NA 0.624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027113 Vd NA 1.185 L/kg 1compartment NA NA Human Human +DTXSID8027084 TK.Half.Life NA 2.495 hours 1compartment NA NA Rat Human +DTXSID8027084 Css NA 0.1087 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027084 Css NA 0.4181 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027084 Css NA 0.07706 mg/L PBTK NA 50% Rat Human +DTXSID8027084 Css NA 0.2528 mg/L PBTK NA 95% Rat Human +DTXSID8027086 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027086 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027086 Vd NA 3.07 L/kg 1compartment NA NA Human Human +DTXSID8027086 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID8027086 TK.Half.Life NA 79.32 hours 1compartment NA NA Human Human +DTXSID8027086 Css NA 1.72 mg/L 3compartmentss NA 50% Human Human +DTXSID8027086 Css NA 12.42 mg/L 3compartmentss NA 95% Human Human +DTXSID8027086 Css NA 1.184 mg/L PBTK NA 50% Human Human +DTXSID8027086 Css NA 8.197 mg/L PBTK NA 95% Human Human +DTXSID8027086 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027086 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027086 Vd NA 2.3 L/kg 1compartment NA NA Rat Human +DTXSID8027086 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID8027086 TK.Half.Life NA 11.49 hours 1compartment NA NA Rat Human +DTXSID8027086 Css NA 0.01883 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027086 Css NA 0.1233 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027086 Css NA 0.0124 mg/L PBTK NA 50% Rat Human +DTXSID8027086 Css NA 0.07883 mg/L PBTK NA 95% Rat Human +DTXSID8027113 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027113 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027113 Vd NA 1.186 L/kg 1compartment NA NA Human Human DTXSID8027113 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8027113 TK.Half.Life NA 13.26 hours 1compartment NA NA Human Human -DTXSID8027113 Css NA 1.153 mg/L 3compartmentss NA 50% Human Human -DTXSID8027113 Css NA 8.202 mg/L 3compartmentss NA 95% Human Human -DTXSID8027113 Css NA 1.002 mg/L PBTK NA 50% Human Human -DTXSID8027113 Css NA 5.356 mg/L PBTK NA 95% Human Human -DTXSID8027113 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027113 Fup NA 0.624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027113 Vd NA 1.074 L/kg 1compartment NA NA Rat Human +DTXSID8027113 TK.Half.Life NA 13.25 hours 1compartment NA NA Human Human +DTXSID8027113 Css NA 1.117 mg/L 3compartmentss NA 50% Human Human +DTXSID8027113 Css NA 7.776 mg/L 3compartmentss NA 95% Human Human +DTXSID8027113 Css NA 0.9683 mg/L PBTK NA 50% Human Human +DTXSID8027113 Css NA 5.096 mg/L PBTK NA 95% Human Human +DTXSID8027113 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027113 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027113 Vd NA 1.075 L/kg 1compartment NA NA Rat Human DTXSID8027113 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8027113 TK.Half.Life NA 3.866 hours 1compartment NA NA Rat Human -DTXSID8027113 Css NA 0.3054 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027113 Css NA 1.962 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027113 Css NA 0.2552 mg/L PBTK NA 50% Rat Human -DTXSID8027113 Css NA 1.184 mg/L PBTK NA 95% Rat Human +DTXSID8027113 Css NA 0.06917 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027113 Css NA 0.4446 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027113 Css NA 0.05977 mg/L PBTK NA 50% Rat Human +DTXSID8027113 Css NA 0.2779 mg/L PBTK NA 95% Rat Human DTXSID8027163 Clint NA 0.1015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8027163 Fup NA 0.5616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027163 Vd NA 1.547 L/kg 1compartment NA NA Human Human +DTXSID8027163 Vd NA 1.7 L/kg 1compartment NA NA Human Human DTXSID8027163 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8027163 TK.Half.Life NA 15.28 hours 1compartment NA NA Human Human -DTXSID8027163 Css NA 0.9324 mg/L 3compartmentss NA 50% Human Human -DTXSID8027163 Css NA 6.893 mg/L 3compartmentss NA 95% Human Human -DTXSID8027163 Css NA 0.8678 mg/L PBTK NA 50% Human Human -DTXSID8027163 Css NA 4.523 mg/L PBTK NA 95% Human Human +DTXSID8027163 TK.Half.Life NA 16.79 hours 1compartment NA NA Human Human +DTXSID8027163 Css NA 0.7694 mg/L 3compartmentss NA 50% Human Human +DTXSID8027163 Css NA 6.141 mg/L 3compartmentss NA 95% Human Human +DTXSID8027163 Css NA 0.7307 mg/L PBTK NA 50% Human Human +DTXSID8027163 Css NA 4.047 mg/L PBTK NA 95% Human Human DTXSID8027163 Clint NA 0.1015 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8027163 Fup NA 0.5616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027163 Vd NA 1.563 L/kg 1compartment NA NA Rat Human +DTXSID8027163 Vd NA 1.715 L/kg 1compartment NA NA Rat Human DTXSID8027163 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027163 TK.Half.Life NA 5.677 hours 1compartment NA NA Rat Human -DTXSID8027163 Css NA 0.2694 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027163 Css NA 1.939 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027163 Css NA 0.2422 mg/L PBTK NA 50% Rat Human -DTXSID8027163 Css NA 1.192 mg/L PBTK NA 95% Rat Human +DTXSID8027163 TK.Half.Life NA 6.228 hours 1compartment NA NA Rat Human +DTXSID8027163 Css NA 0.01614 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027163 Css NA 0.1527 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027163 Css NA 0.01494 mg/L PBTK NA 50% Rat Human +DTXSID8027163 Css NA 0.1048 mg/L PBTK NA 95% Rat Human DTXSID8027169 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8027169 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027169 Vd NA 0.5453 L/kg 1compartment NA NA Human Human +DTXSID8027169 Vd NA 0.5416 L/kg 1compartment NA NA Human Human DTXSID8027169 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027169 TK.Half.Life NA 5.001 hours 1compartment NA NA Human Human -DTXSID8027169 Css NA 1.121 mg/L 3compartmentss NA 50% Human Human -DTXSID8027169 Css NA 7.122 mg/L 3compartmentss NA 95% Human Human -DTXSID8027169 Css NA 0.8713 mg/L PBTK NA 50% Human Human -DTXSID8027169 Css NA 4.478 mg/L PBTK NA 95% Human Human +DTXSID8027169 TK.Half.Life NA 4.969 hours 1compartment NA NA Human Human +DTXSID8027169 Css NA 0.9748 mg/L 3compartmentss NA 50% Human Human +DTXSID8027169 Css NA 6.164 mg/L 3compartmentss NA 95% Human Human +DTXSID8027169 Css NA 0.7519 mg/L PBTK NA 50% Human Human +DTXSID8027169 Css NA 3.908 mg/L PBTK NA 95% Human Human DTXSID8027169 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8027169 Fup NA 0.7053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027169 Vd NA 0.5854 L/kg 1compartment NA NA Rat Human +DTXSID8027169 Vd NA 0.5825 L/kg 1compartment NA NA Rat Human DTXSID8027169 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027169 TK.Half.Life NA 1.83 hours 1compartment NA NA Rat Human -DTXSID8027169 Css NA 0.2987 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027169 Css NA 1.854 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027169 Css NA 0.2218 mg/L PBTK NA 50% Rat Human -DTXSID8027169 Css NA 1.078 mg/L PBTK NA 95% Rat Human -DTXSID8027240 Clint NA 2.444 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027240 Fup NA 0.328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027240 Vd NA 1.522 L/kg 1compartment NA NA Human Human +DTXSID8027169 TK.Half.Life NA 1.821 hours 1compartment NA NA Rat Human +DTXSID8027169 Css NA 0.01862 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027169 Css NA 0.1461 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027169 Css NA 0.01393 mg/L PBTK NA 50% Rat Human +DTXSID8027169 Css NA 0.09074 mg/L PBTK NA 95% Rat Human +DTXSID8027240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027240 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027240 Vd NA 1.054 L/kg 1compartment NA NA Human Human DTXSID8027240 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027240 TK.Half.Life NA 7.903 hours 1compartment NA NA Human Human -DTXSID8027240 Css NA 0.5362 mg/L 3compartmentss NA 50% Human Human -DTXSID8027240 Css NA 2.636 mg/L 3compartmentss NA 95% Human Human -DTXSID8027240 Css NA 0.4146 mg/L PBTK NA 50% Human Human -DTXSID8027240 Css NA 1.789 mg/L PBTK NA 95% Human Human -DTXSID8027240 Clint NA 2.444 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027240 Fup NA 0.328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027240 Vd NA 1.237 L/kg 1compartment NA NA Rat Human +DTXSID8027240 TK.Half.Life NA 2.034 hours 1compartment NA NA Human Human +DTXSID8027240 Css NA 0.1549 mg/L 3compartmentss NA 50% Human Human +DTXSID8027240 Css NA 1.171 mg/L 3compartmentss NA 95% Human Human +DTXSID8027240 Css NA 0.105 mg/L PBTK NA 50% Human Human +DTXSID8027240 Css NA 0.7533 mg/L PBTK NA 95% Human Human +DTXSID8027240 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027240 Fup 0.16 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027240 Vd NA 0.8499 L/kg 1compartment NA NA Rat Human DTXSID8027240 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027240 TK.Half.Life NA 3.02 hours 1compartment NA NA Rat Human -DTXSID8027240 Css NA 0.2456 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027240 Css NA 0.941 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027240 Css NA 0.1826 mg/L PBTK NA 50% Rat Human -DTXSID8027240 Css NA 0.5941 mg/L PBTK NA 95% Rat Human +DTXSID8027240 TK.Half.Life NA 0.8812 hours 1compartment NA NA Rat Human +DTXSID8027240 Css NA 0.01965 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027240 Css NA 0.1151 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027240 Css NA 0.01318 mg/L PBTK NA 50% Rat Human +DTXSID8027240 Css NA 0.07189 mg/L PBTK NA 95% Rat Human DTXSID8027246 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8027246 Fup NA 0.9558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8027246 Vd NA 0.7822 L/kg 1compartment NA NA Human Human DTXSID8027246 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8027246 TK.Half.Life NA 5.299 hours 1compartment NA NA Human Human -DTXSID8027246 Css NA 0.8869 mg/L 3compartmentss NA 50% Human Human -DTXSID8027246 Css NA 5.092 mg/L 3compartmentss NA 95% Human Human -DTXSID8027246 Css NA 0.743 mg/L PBTK NA 50% Human Human -DTXSID8027246 Css NA 3.351 mg/L PBTK NA 95% Human Human +DTXSID8027246 Css NA 0.7557 mg/L 3compartmentss NA 50% Human Human +DTXSID8027246 Css NA 4.425 mg/L 3compartmentss NA 95% Human Human +DTXSID8027246 Css NA 0.6334 mg/L PBTK NA 50% Human Human +DTXSID8027246 Css NA 2.892 mg/L PBTK NA 95% Human Human DTXSID8027246 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8027246 Fup NA 0.9558 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8027246 Vd NA 0.8153 L/kg 1compartment NA NA Rat Human DTXSID8027246 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8027246 TK.Half.Life NA 1.881 hours 1compartment NA NA Rat Human -DTXSID8027246 Css NA 0.2278 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027246 Css NA 1.19 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027246 Css NA 0.1852 mg/L PBTK NA 50% Rat Human -DTXSID8027246 Css NA 0.7254 mg/L PBTK NA 95% Rat Human -DTXSID8027292 Clint NA 261.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027292 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027292 Vd NA 9.1 L/kg 1compartment NA NA Human Human -DTXSID8027292 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8027292 TK.Half.Life NA 26.68 hours 1compartment NA NA Human Human -DTXSID8027292 Css NA 0.1787 mg/L 3compartmentss NA 50% Human Human -DTXSID8027292 Css NA 1.106 mg/L 3compartmentss NA 95% Human Human -DTXSID8027292 Css NA 0.2002 mg/L PBTK NA 50% Human Human -DTXSID8027292 Css NA 1.171 mg/L PBTK NA 95% Human Human -DTXSID8027292 Clint NA 261.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027292 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027292 Vd NA 7.134 L/kg 1compartment NA NA Rat Human -DTXSID8027292 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8027292 TK.Half.Life NA 4.513 hours 1compartment NA NA Rat Human -DTXSID8027292 Css NA 0.09865 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027292 Css NA 0.4159 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027292 Css NA 0.1099 mg/L PBTK NA 50% Rat Human -DTXSID8027292 Css NA 0.4652 mg/L PBTK NA 95% Rat Human -DTXSID8027294 Clint NA 0.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027294 Fup NA 0.9022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027294 Vd NA 1.063 L/kg 1compartment NA NA Human Human +DTXSID8027246 Css NA 0.01396 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027246 Css NA 0.105 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027246 Css NA 0.01124 mg/L PBTK NA 50% Rat Human +DTXSID8027246 Css NA 0.06841 mg/L PBTK NA 95% Rat Human +DTXSID8027294 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027294 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027294 Vd NA 0.9284 L/kg 1compartment NA NA Human Human DTXSID8027294 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027294 TK.Half.Life NA 4.944 hours 1compartment NA NA Human Human -DTXSID8027294 Css NA 0.5136 mg/L 3compartmentss NA 50% Human Human -DTXSID8027294 Css NA 2.145 mg/L 3compartmentss NA 95% Human Human -DTXSID8027294 Css NA 0.4568 mg/L PBTK NA 50% Human Human -DTXSID8027294 Css NA 1.533 mg/L PBTK NA 95% Human Human -DTXSID8027294 Clint NA 0.362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027294 Fup NA 0.9022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027294 Vd NA 1.042 L/kg 1compartment NA NA Rat Human +DTXSID8027294 TK.Half.Life NA 8.458 hours 1compartment NA NA Human Human +DTXSID8027294 Css NA 0.8684 mg/L 3compartmentss NA 50% Human Human +DTXSID8027294 Css NA 5.815 mg/L 3compartmentss NA 95% Human Human +DTXSID8027294 Css NA 0.7409 mg/L PBTK NA 50% Human Human +DTXSID8027294 Css NA 3.799 mg/L PBTK NA 95% Human Human +DTXSID8027294 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027294 Fup 0.723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027294 Vd NA 0.9082 L/kg 1compartment NA NA Rat Human DTXSID8027294 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027294 TK.Half.Life NA 1.994 hours 1compartment NA NA Rat Human -DTXSID8027294 Css NA 0.1628 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027294 Css NA 0.6143 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027294 Css NA 0.1437 mg/L PBTK NA 50% Rat Human -DTXSID8027294 Css NA 0.406 mg/L PBTK NA 95% Rat Human +DTXSID8027294 TK.Half.Life NA 2.781 hours 1compartment NA NA Rat Human +DTXSID8027294 Css NA 0.01674 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027294 Css NA 0.1316 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027294 Css NA 0.01376 mg/L PBTK NA 50% Rat Human +DTXSID8027294 Css NA 0.0854 mg/L PBTK NA 95% Rat Human DTXSID8027321 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8027321 Fup NA 0.4089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027321 Vd NA 0.3724 L/kg 1compartment NA NA Human Human +DTXSID8027321 Vd NA 0.3179 L/kg 1compartment NA NA Human Human DTXSID8027321 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027321 TK.Half.Life NA 5.894 hours 1compartment NA NA Human Human -DTXSID8027321 Css NA 1.912 mg/L 3compartmentss NA 50% Human Human -DTXSID8027321 Css NA 7.963 mg/L 3compartmentss NA 95% Human Human -DTXSID8027321 Css NA 1.32 mg/L PBTK NA 50% Human Human -DTXSID8027321 Css NA 4.903 mg/L PBTK NA 95% Human Human +DTXSID8027321 TK.Half.Life NA 5.03 hours 1compartment NA NA Human Human +DTXSID8027321 Css NA 1.886 mg/L 3compartmentss NA 50% Human Human +DTXSID8027321 Css NA 7.892 mg/L 3compartmentss NA 95% Human Human +DTXSID8027321 Css NA 1.278 mg/L PBTK NA 50% Human Human +DTXSID8027321 Css NA 4.899 mg/L PBTK NA 95% Human Human DTXSID8027321 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8027321 Fup NA 0.4089 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027321 Vd NA 0.3829 L/kg 1compartment NA NA Rat Human +DTXSID8027321 Vd NA 0.3364 L/kg 1compartment NA NA Rat Human DTXSID8027321 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027321 TK.Half.Life NA 2.065 hours 1compartment NA NA Rat Human -DTXSID8027321 Css NA 0.5228 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027321 Css NA 1.917 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027321 Css NA 0.3438 mg/L PBTK NA 50% Rat Human -DTXSID8027321 Css NA 1.105 mg/L PBTK NA 95% Rat Human -DTXSID8027323 Clint NA 8.643 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027323 Fup NA 0.0654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027323 Vd NA 2.581 L/kg 1compartment NA NA Human Human -DTXSID8027323 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8027323 TK.Half.Life NA 37.19 hours 1compartment NA NA Human Human -DTXSID8027323 Css NA 1.885 mg/L 3compartmentss NA 50% Human Human -DTXSID8027323 Css NA 10.9 mg/L 3compartmentss NA 95% Human Human -DTXSID8027323 Css NA 1.282 mg/L PBTK NA 50% Human Human -DTXSID8027323 Css NA 7.18 mg/L PBTK NA 95% Human Human -DTXSID8027323 Clint NA 8.643 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027323 Fup NA 0.0654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027323 Vd NA 1.938 L/kg 1compartment NA NA Rat Human -DTXSID8027323 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8027323 TK.Half.Life NA 8.6 hours 1compartment NA NA Rat Human -DTXSID8027323 Css NA 1.022 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027323 Css NA 4.472 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027323 Css NA 0.664 mg/L PBTK NA 50% Rat Human -DTXSID8027323 Css NA 2.805 mg/L PBTK NA 95% Rat Human -DTXSID8027377 Clint NA 3.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027377 Fup NA 0.4715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027377 Vd NA 1.347 L/kg 1compartment NA NA Human Human -DTXSID8027377 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027377 TK.Half.Life NA 3.986 hours 1compartment NA NA Human Human -DTXSID8027377 Css NA 0.2694 mg/L 3compartmentss NA 50% Human Human -DTXSID8027377 Css NA 1.675 mg/L 3compartmentss NA 95% Human Human -DTXSID8027377 Css NA 0.2204 mg/L PBTK NA 50% Human Human -DTXSID8027377 Css NA 1.153 mg/L PBTK NA 95% Human Human -DTXSID8027377 Clint NA 3.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027377 Fup NA 0.4715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027377 Vd NA 1.153 L/kg 1compartment NA NA Rat Human -DTXSID8027377 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027377 TK.Half.Life NA 1.72 hours 1compartment NA NA Rat Human -DTXSID8027377 Css NA 0.1253 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027377 Css NA 0.6283 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027377 Css NA 0.09947 mg/L PBTK NA 50% Rat Human -DTXSID8027377 Css NA 0.3979 mg/L PBTK NA 95% Rat Human -DTXSID8027402 Clint NA 488.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027402 Fup NA 0.3206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027402 Vd NA 1.315 L/kg 1compartment NA NA Human Human +DTXSID8027321 TK.Half.Life NA 1.815 hours 1compartment NA NA Rat Human +DTXSID8027321 Css NA 0.1216 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027321 Css NA 0.4292 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027321 Css NA 0.08022 mg/L PBTK NA 50% Rat Human +DTXSID8027321 Css NA 0.2537 mg/L PBTK NA 95% Rat Human +DTXSID8027323 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027323 Fup 0.0294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027323 Vd NA 2.136 L/kg 1compartment NA NA Human Human +DTXSID8027323 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8027323 TK.Half.Life NA 17.68 hours 1compartment NA NA Human Human +DTXSID8027323 Css NA 1.168 mg/L 3compartmentss NA 50% Human Human +DTXSID8027323 Css NA 9.553 mg/L 3compartmentss NA 95% Human Human +DTXSID8027323 Css NA 0.7576 mg/L PBTK NA 50% Human Human +DTXSID8027323 Css NA 5.899 mg/L PBTK NA 95% Human Human +DTXSID8027323 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027323 Fup 0.0294 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027323 Vd NA 1.593 L/kg 1compartment NA NA Rat Human +DTXSID8027323 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8027323 TK.Half.Life NA 5.377 hours 1compartment NA NA Rat Human +DTXSID8027323 Css NA 0.1514 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027323 Css NA 0.965 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027323 Css NA 0.09654 mg/L PBTK NA 50% Rat Human +DTXSID8027323 Css NA 0.5808 mg/L PBTK NA 95% Rat Human +DTXSID8027400 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027400 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027400 Vd NA 0.5615 L/kg 1compartment NA NA Human Human +DTXSID8027400 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8027400 TK.Half.Life NA 7.742 hours 1compartment NA NA Human Human +DTXSID8027400 Css NA 1.322 mg/L 3compartmentss NA 50% Human Human +DTXSID8027400 Css NA 6.229 mg/L 3compartmentss NA 95% Human Human +DTXSID8027400 Css NA 0.9896 mg/L PBTK NA 50% Human Human +DTXSID8027400 Css NA 3.983 mg/L PBTK NA 95% Human Human +DTXSID8027400 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027400 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027400 Vd NA 0.5744 L/kg 1compartment NA NA Rat Human +DTXSID8027400 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8027400 TK.Half.Life NA 2.696 hours 1compartment NA NA Rat Human +DTXSID8027400 Css NA 0.0242 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027400 Css NA 0.1638 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027400 Css NA 0.0174 mg/L PBTK NA 50% Rat Human +DTXSID8027400 Css NA 0.1054 mg/L PBTK NA 95% Rat Human +DTXSID8027402 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027402 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027402 Vd NA 1.397 L/kg 1compartment NA NA Human Human DTXSID8027402 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027402 TK.Half.Life NA 0.9754 hours 1compartment NA NA Human Human -DTXSID8027402 Css NA 0.003247 mg/L 3compartmentss NA 50% Human Human -DTXSID8027402 Css NA 0.02561 mg/L 3compartmentss NA 95% Human Human -DTXSID8027402 Css NA 0.002472 mg/L PBTK NA 50% Human Human -DTXSID8027402 Css NA 0.01789 mg/L PBTK NA 95% Human Human -DTXSID8027402 Clint NA 488.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027402 Fup NA 0.3206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027402 Vd NA 1.088 L/kg 1compartment NA NA Rat Human +DTXSID8027402 TK.Half.Life NA 2.039 hours 1compartment NA NA Human Human +DTXSID8027402 Css NA 0.0853 mg/L 3compartmentss NA 50% Human Human +DTXSID8027402 Css NA 0.6109 mg/L 3compartmentss NA 95% Human Human +DTXSID8027402 Css NA 0.06309 mg/L PBTK NA 50% Human Human +DTXSID8027402 Css NA 0.4212 mg/L PBTK NA 95% Human Human +DTXSID8027402 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027402 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027402 Vd NA 1.13 L/kg 1compartment NA NA Rat Human DTXSID8027402 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027402 TK.Half.Life NA 0.354 hours 1compartment NA NA Rat Human -DTXSID8027402 Css NA 0.001794 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027402 Css NA 0.01167 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027402 Css NA 0.001316 mg/L PBTK NA 50% Rat Human -DTXSID8027402 Css NA 0.007872 mg/L PBTK NA 95% Rat Human -DTXSID8027452 Clint NA 32.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027452 Fup NA 0.1151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027452 Vd NA 2.307 L/kg 1compartment NA NA Human Human -DTXSID8027452 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027452 TK.Half.Life NA 6.075 hours 1compartment NA NA Human Human -DTXSID8027452 Css NA 0.2643 mg/L 3compartmentss NA 50% Human Human -DTXSID8027452 Css NA 1.882 mg/L 3compartmentss NA 95% Human Human -DTXSID8027452 Css NA 0.1819 mg/L PBTK NA 50% Human Human -DTXSID8027452 Css NA 1.219 mg/L PBTK NA 95% Human Human -DTXSID8027452 Clint NA 32.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027452 Fup NA 0.1151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027452 Vd NA 1.745 L/kg 1compartment NA NA Rat Human -DTXSID8027452 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027452 TK.Half.Life NA 1.812 hours 1compartment NA NA Rat Human -DTXSID8027452 Css NA 0.1469 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027452 Css NA 0.7736 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027452 Css NA 0.09626 mg/L PBTK NA 50% Rat Human -DTXSID8027452 Css NA 0.4848 mg/L PBTK NA 95% Rat Human -DTXSID8027454 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027454 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027454 Vd NA 0.8718 L/kg 1compartment NA NA Human Human +DTXSID8027402 TK.Half.Life NA 0.8237 hours 1compartment NA NA Rat Human +DTXSID8027402 Css NA 0.01071 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027402 Css NA 0.05657 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027402 Css NA 0.007937 mg/L PBTK NA 50% Rat Human +DTXSID8027402 Css NA 0.03946 mg/L PBTK NA 95% Rat Human +DTXSID8027454 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027454 Fup 0.849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027454 Vd NA 0.7784 L/kg 1compartment NA NA Human Human DTXSID8027454 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027454 TK.Half.Life NA 5.658 hours 1compartment NA NA Human Human -DTXSID8027454 Css NA 0.8048 mg/L 3compartmentss NA 50% Human Human -DTXSID8027454 Css NA 5.595 mg/L 3compartmentss NA 95% Human Human -DTXSID8027454 Css NA 0.6972 mg/L PBTK NA 50% Human Human -DTXSID8027454 Css NA 3.652 mg/L PBTK NA 95% Human Human -DTXSID8027454 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027454 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027454 Vd NA 0.8969 L/kg 1compartment NA NA Rat Human +DTXSID8027454 TK.Half.Life NA 5.945 hours 1compartment NA NA Human Human +DTXSID8027454 Css NA 0.807 mg/L 3compartmentss NA 50% Human Human +DTXSID8027454 Css NA 5.158 mg/L 3compartmentss NA 95% Human Human +DTXSID8027454 Css NA 0.6725 mg/L PBTK NA 50% Human Human +DTXSID8027454 Css NA 3.34 mg/L PBTK NA 95% Human Human +DTXSID8027454 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027454 Fup 0.849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027454 Vd NA 0.802 L/kg 1compartment NA NA Rat Human DTXSID8027454 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027454 TK.Half.Life NA 1.979 hours 1compartment NA NA Rat Human -DTXSID8027454 Css NA 0.2028 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027454 Css NA 1.247 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027454 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID8027454 Css NA 0.7608 mg/L PBTK NA 95% Rat Human -DTXSID8027585 Clint NA 27.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027585 Fup NA 0.2671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027585 Vd NA 0.8673 L/kg 1compartment NA NA Human Human +DTXSID8027454 TK.Half.Life NA 2.083 hours 1compartment NA NA Rat Human +DTXSID8027454 Css NA 0.01498 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027454 Css NA 0.1107 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027454 Css NA 0.01206 mg/L PBTK NA 50% Rat Human +DTXSID8027454 Css NA 0.07222 mg/L PBTK NA 95% Rat Human +DTXSID8027585 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027585 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027585 Vd NA 1.167 L/kg 1compartment NA NA Human Human DTXSID8027585 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027585 TK.Half.Life NA 1.09 hours 1compartment NA NA Human Human -DTXSID8027585 Css NA 0.06388 mg/L 3compartmentss NA 50% Human Human -DTXSID8027585 Css NA 0.4688 mg/L 3compartmentss NA 95% Human Human -DTXSID8027585 Css NA 0.04604 mg/L PBTK NA 50% Human Human -DTXSID8027585 Css NA 0.3093 mg/L PBTK NA 95% Human Human -DTXSID8027585 Clint NA 27.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027585 Fup NA 0.2671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027585 Vd NA 0.7545 L/kg 1compartment NA NA Rat Human +DTXSID8027585 TK.Half.Life NA 2.332 hours 1compartment NA NA Human Human +DTXSID8027585 Css NA 0.1532 mg/L 3compartmentss NA 50% Human Human +DTXSID8027585 Css NA 1.086 mg/L 3compartmentss NA 95% Human Human +DTXSID8027585 Css NA 0.1218 mg/L PBTK NA 50% Human Human +DTXSID8027585 Css NA 0.7615 mg/L PBTK NA 95% Human Human +DTXSID8027585 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027585 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027585 Vd NA 1.013 L/kg 1compartment NA NA Rat Human DTXSID8027585 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027585 TK.Half.Life NA 0.4902 hours 1compartment NA NA Rat Human -DTXSID8027585 Css NA 0.03496 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027585 Css NA 0.1986 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027585 Css NA 0.02405 mg/L PBTK NA 50% Rat Human -DTXSID8027585 Css NA 0.1244 mg/L PBTK NA 95% Rat Human -DTXSID8027589 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027589 Fup NA 0.6708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027589 Vd NA 1.091 L/kg 1compartment NA NA Human Human -DTXSID8027589 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8027589 TK.Half.Life NA 11.06 hours 1compartment NA NA Human Human -DTXSID8027589 Css NA 1.076 mg/L 3compartmentss NA 50% Human Human -DTXSID8027589 Css NA 7.083 mg/L 3compartmentss NA 95% Human Human -DTXSID8027589 Css NA 0.9296 mg/L PBTK NA 50% Human Human -DTXSID8027589 Css NA 4.57 mg/L PBTK NA 95% Human Human -DTXSID8027589 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027589 Fup NA 0.6708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027589 Vd NA 1.017 L/kg 1compartment NA NA Rat Human +DTXSID8027585 TK.Half.Life NA 1.074 hours 1compartment NA NA Rat Human +DTXSID8027585 Css NA 0.01764 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027585 Css NA 0.09457 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027585 Css NA 0.01415 mg/L PBTK NA 50% Rat Human +DTXSID8027585 Css NA 0.06322 mg/L PBTK NA 95% Rat Human +DTXSID8027589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027589 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027589 Vd NA 1.139 L/kg 1compartment NA NA Human Human +DTXSID8027589 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8027589 TK.Half.Life NA 0.9856 hours 1compartment NA NA Human Human +DTXSID8027589 Css NA 0.03181 mg/L 3compartmentss NA 50% Human Human +DTXSID8027589 Css NA 0.3361 mg/L 3compartmentss NA 95% Human Human +DTXSID8027589 Css NA 0.02651 mg/L PBTK NA 50% Human Human +DTXSID8027589 Css NA 0.2361 mg/L PBTK NA 95% Human Human +DTXSID8027589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027589 Fup 0.627 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027589 Vd NA 1.042 L/kg 1compartment NA NA Rat Human DTXSID8027589 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027589 TK.Half.Life NA 3.385 hours 1compartment NA NA Rat Human -DTXSID8027589 Css NA 0.2838 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027589 Css NA 1.784 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027589 Css NA 0.2372 mg/L PBTK NA 50% Rat Human -DTXSID8027589 Css NA 1.079 mg/L PBTK NA 95% Rat Human -DTXSID8027747 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027747 Fup NA 0.3463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027747 Vd NA 1.044 L/kg 1compartment NA NA Human Human -DTXSID8027747 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8027747 TK.Half.Life NA 21.34 hours 1compartment NA NA Human Human -DTXSID8027747 Css NA 2.205 mg/L 3compartmentss NA 50% Human Human -DTXSID8027747 Css NA 8.994 mg/L 3compartmentss NA 95% Human Human -DTXSID8027747 Css NA 1.678 mg/L PBTK NA 50% Human Human -DTXSID8027747 Css NA 5.877 mg/L PBTK NA 95% Human Human -DTXSID8027747 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027747 Fup NA 0.3463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027747 Vd NA 0.8999 L/kg 1compartment NA NA Rat Human +DTXSID8027589 TK.Half.Life NA 0.4415 hours 1compartment NA NA Rat Human +DTXSID8027589 Css NA 0.003746 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027589 Css NA 0.03662 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027589 Css NA 0.003227 mg/L PBTK NA 50% Rat Human +DTXSID8027589 Css NA 0.02502 mg/L PBTK NA 95% Rat Human +DTXSID8027747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027747 Fup 0.37 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027747 Vd NA 1.544 L/kg 1compartment NA NA Human Human +DTXSID8027747 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8027747 TK.Half.Life NA 1.894 hours 1compartment NA NA Human Human +DTXSID8027747 Css NA 0.06083 mg/L 3compartmentss NA 50% Human Human +DTXSID8027747 Css NA 0.4667 mg/L 3compartmentss NA 95% Human Human +DTXSID8027747 Css NA 0.0473 mg/L PBTK NA 50% Human Human +DTXSID8027747 Css NA 0.3305 mg/L PBTK NA 95% Human Human +DTXSID8027747 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027747 Fup 0.37 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027747 Vd NA 1.26 L/kg 1compartment NA NA Rat Human DTXSID8027747 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027747 TK.Half.Life NA 5.859 hours 1compartment NA NA Rat Human -DTXSID8027747 Css NA 0.6069 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027747 Css NA 2.071 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027747 Css NA 0.4427 mg/L PBTK NA 50% Rat Human -DTXSID8027747 Css NA 1.256 mg/L PBTK NA 95% Rat Human -DTXSID8027793 Clint NA 9.484 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027793 Fup NA 0.0809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027793 Vd NA 2.525 L/kg 1compartment NA NA Human Human -DTXSID8027793 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8027793 TK.Half.Life NA 27.14 hours 1compartment NA NA Human Human -DTXSID8027793 Css NA 1.415 mg/L 3compartmentss NA 50% Human Human -DTXSID8027793 Css NA 8.421 mg/L 3compartmentss NA 95% Human Human -DTXSID8027793 Css NA 0.9674 mg/L PBTK NA 50% Human Human -DTXSID8027793 Css NA 5.584 mg/L PBTK NA 95% Human Human -DTXSID8027793 Clint NA 9.484 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027793 Fup NA 0.0809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027793 Vd NA 1.898 L/kg 1compartment NA NA Rat Human -DTXSID8027793 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8027793 TK.Half.Life NA 6.595 hours 1compartment NA NA Rat Human -DTXSID8027793 Css NA 0.7694 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027793 Css NA 3.403 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027793 Css NA 0.4998 mg/L PBTK NA 50% Rat Human -DTXSID8027793 Css NA 2.143 mg/L PBTK NA 95% Rat Human +DTXSID8027747 TK.Half.Life NA 0.7458 hours 1compartment NA NA Rat Human +DTXSID8027747 Css NA 0.007513 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027747 Css NA 0.04432 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027747 Css NA 0.005926 mg/L PBTK NA 50% Rat Human +DTXSID8027747 Css NA 0.03132 mg/L PBTK NA 95% Rat Human +DTXSID8027793 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027793 Fup 0.0357 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027793 Vd NA 2.046 L/kg 1compartment NA NA Human Human +DTXSID8027793 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8027793 TK.Half.Life NA 14.34 hours 1compartment NA NA Human Human +DTXSID8027793 Css NA 0.97 mg/L 3compartmentss NA 50% Human Human +DTXSID8027793 Css NA 6.634 mg/L 3compartmentss NA 95% Human Human +DTXSID8027793 Css NA 0.6291 mg/L PBTK NA 50% Human Human +DTXSID8027793 Css NA 4.194 mg/L PBTK NA 95% Human Human +DTXSID8027793 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027793 Fup 0.0357 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027793 Vd NA 1.527 L/kg 1compartment NA NA Rat Human +DTXSID8027793 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8027793 TK.Half.Life NA 4.551 hours 1compartment NA NA Rat Human +DTXSID8027793 Css NA 0.1257 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027793 Css NA 0.6996 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027793 Css NA 0.08016 mg/L PBTK NA 50% Rat Human +DTXSID8027793 Css NA 0.4346 mg/L PBTK NA 95% Rat Human DTXSID8027795 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8027795 Fup NA 0.0952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027795 Vd NA 2.355 L/kg 1compartment NA NA Human Human -DTXSID8027795 Days.Css NA 97 Days PBTK NA NA Human Human -DTXSID8027795 TK.Half.Life NA 414.8 hours 1compartment NA NA Human Human -DTXSID8027795 Css NA 23.12 mg/L 3compartmentss NA 50% Human Human -DTXSID8027795 Css NA 76.89 mg/L 3compartmentss NA 95% Human Human -DTXSID8027795 Css NA 15.78 mg/L PBTK NA 50% Human Human -DTXSID8027795 Css NA 48.08 mg/L PBTK NA 95% Human Human +DTXSID8027795 Vd NA 2.24 L/kg 1compartment NA NA Human Human +DTXSID8027795 Days.Css NA 80 Days PBTK NA NA Human Human +DTXSID8027795 TK.Half.Life NA 349.2 hours 1compartment NA NA Human Human +DTXSID8027795 Css NA 20.21 mg/L 3compartmentss NA 50% Human Human +DTXSID8027795 Css NA 69.01 mg/L 3compartmentss NA 95% Human Human +DTXSID8027795 Css NA 13.74 mg/L PBTK NA 50% Human Human +DTXSID8027795 Css NA 43 mg/L PBTK NA 95% Human Human DTXSID8027795 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8027795 Fup NA 0.0952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027795 Vd NA 1.776 L/kg 1compartment NA NA Rat Human -DTXSID8027795 Days.Css NA 23 Days PBTK NA NA Rat Human -DTXSID8027795 TK.Half.Life NA 56.72 hours 1compartment NA NA Rat Human -DTXSID8027795 Css NA 6.297 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027795 Css NA 17.65 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027795 Css NA 4.098 mg/L PBTK NA 50% Rat Human -DTXSID8027795 Css NA 10.31 mg/L PBTK NA 95% Rat Human -DTXSID8027797 Clint NA 65.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027797 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027797 Vd NA 1.515 L/kg 1compartment NA NA Human Human -DTXSID8027797 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027797 TK.Half.Life NA 5.462 hours 1compartment NA NA Human Human -DTXSID8027797 Css NA 0.4734 mg/L 3compartmentss NA 50% Human Human -DTXSID8027797 Css NA 4.214 mg/L 3compartmentss NA 95% Human Human -DTXSID8027797 Css NA 0.2976 mg/L PBTK NA 50% Human Human -DTXSID8027797 Css NA 2.523 mg/L PBTK NA 95% Human Human -DTXSID8027797 Clint NA 65.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027797 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027797 Vd NA 1.124 L/kg 1compartment NA NA Rat Human -DTXSID8027797 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027797 TK.Half.Life NA 2.06 hours 1compartment NA NA Rat Human -DTXSID8027797 Css NA 0.2713 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027797 Css NA 2.016 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027797 Css NA 0.1597 mg/L PBTK NA 50% Rat Human -DTXSID8027797 Css NA 1.146 mg/L PBTK NA 95% Rat Human -DTXSID8027822 Clint NA 23.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027822 Fup NA 0.3179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027822 Vd NA 2.633 L/kg 1compartment NA NA Human Human -DTXSID8027822 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027822 TK.Half.Life NA 5.454 hours 1compartment NA NA Human Human -DTXSID8027822 Css NA 0.1638 mg/L 3compartmentss NA 50% Human Human -DTXSID8027822 Css NA 0.9729 mg/L 3compartmentss NA 95% Human Human -DTXSID8027822 Css NA 0.1221 mg/L PBTK NA 50% Human Human -DTXSID8027822 Css NA 0.6901 mg/L PBTK NA 95% Human Human -DTXSID8027822 Clint NA 23.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027822 Fup NA 0.3179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027822 Vd NA 2.018 L/kg 1compartment NA NA Rat Human -DTXSID8027822 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027822 TK.Half.Life NA 1.475 hours 1compartment NA NA Rat Human -DTXSID8027822 Css NA 0.0866 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027822 Css NA 0.4236 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027822 Css NA 0.06279 mg/L PBTK NA 50% Rat Human -DTXSID8027822 Css NA 0.2958 mg/L PBTK NA 95% Rat Human -DTXSID8027826 Clint NA 6.044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027826 Fup NA 0.1519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027826 Vd NA 0.5194 L/kg 1compartment NA NA Human Human +DTXSID8027795 Vd NA 1.691 L/kg 1compartment NA NA Rat Human +DTXSID8027795 Days.Css NA 18 Days PBTK NA NA Rat Human +DTXSID8027795 TK.Half.Life NA 51.27 hours 1compartment NA NA Rat Human +DTXSID8027795 Css NA 1.275 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027795 Css NA 3.648 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027795 Css NA 0.8542 mg/L PBTK NA 50% Rat Human +DTXSID8027795 Css NA 2.199 mg/L PBTK NA 95% Rat Human +DTXSID8027797 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027797 Fup 0.0159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027797 Vd NA 3.583 L/kg 1compartment NA NA Human Human +DTXSID8027797 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID8027797 TK.Half.Life NA 108.2 hours 1compartment NA NA Human Human +DTXSID8027797 Css NA 3.252 mg/L 3compartmentss NA 50% Human Human +DTXSID8027797 Css NA 19.01 mg/L 3compartmentss NA 95% Human Human +DTXSID8027797 Css NA 2.358 mg/L PBTK NA 50% Human Human +DTXSID8027797 Css NA 13.37 mg/L PBTK NA 95% Human Human +DTXSID8027797 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027797 Fup 0.0159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027797 Vd NA 2.698 L/kg 1compartment NA NA Rat Human +DTXSID8027797 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID8027797 TK.Half.Life NA 14.55 hours 1compartment NA NA Rat Human +DTXSID8027797 Css NA 0.4303 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027797 Css NA 2.121 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027797 Css NA 0.3074 mg/L PBTK NA 50% Rat Human +DTXSID8027797 Css NA 1.528 mg/L PBTK NA 95% Rat Human +DTXSID8027826 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027826 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027826 Vd NA 0.4564 L/kg 1compartment NA NA Human Human DTXSID8027826 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027826 TK.Half.Life NA 2.354 hours 1compartment NA NA Human Human -DTXSID8027826 Css NA 0.5498 mg/L 3compartmentss NA 50% Human Human -DTXSID8027826 Css NA 3.797 mg/L 3compartmentss NA 95% Human Human -DTXSID8027826 Css NA 0.3806 mg/L PBTK NA 50% Human Human -DTXSID8027826 Css NA 2.407 mg/L PBTK NA 95% Human Human -DTXSID8027826 Clint NA 6.044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027826 Fup NA 0.1519 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027826 Vd NA 0.5129 L/kg 1compartment NA NA Rat Human +DTXSID8027826 TK.Half.Life NA 9.256 hours 1compartment NA NA Human Human +DTXSID8027826 Css NA 1.256 mg/L 3compartmentss NA 50% Human Human +DTXSID8027826 Css NA 5.507 mg/L 3compartmentss NA 95% Human Human +DTXSID8027826 Css NA 0.8885 mg/L PBTK NA 50% Human Human +DTXSID8027826 Css NA 3.492 mg/L PBTK NA 95% Human Human +DTXSID8027826 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027826 Fup 0.319 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027826 Vd NA 0.4665 L/kg 1compartment NA NA Rat Human DTXSID8027826 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027826 TK.Half.Life NA 1.395 hours 1compartment NA NA Rat Human -DTXSID8027826 Css NA 0.2874 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027826 Css NA 1.478 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027826 Css NA 0.1878 mg/L PBTK NA 50% Rat Human -DTXSID8027826 Css NA 0.8674 mg/L PBTK NA 95% Rat Human -DTXSID8027870 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027870 Fup NA 0.0474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027870 Vd NA 3.082 L/kg 1compartment NA NA Human Human -DTXSID8027870 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8027870 TK.Half.Life NA 14000 hours 1compartment NA NA Human Human -DTXSID8027870 Css NA 525.2 mg/L 3compartmentss NA 50% Human Human -DTXSID8027870 Css NA 1447 mg/L 3compartmentss NA 95% Human Human -DTXSID8027870 Css NA 364.4 mg/L PBTK NA 50% Human Human -DTXSID8027870 Css NA 941.6 mg/L PBTK NA 95% Human Human -DTXSID8027870 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027870 Fup NA 0.0474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027870 Vd NA 2.31 L/kg 1compartment NA NA Rat Human -DTXSID8027870 Days.Css NA 983 Days PBTK NA NA Rat Human -DTXSID8027870 TK.Half.Life NA 934.2 hours 1compartment NA NA Rat Human -DTXSID8027870 Css NA 142.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027870 Css NA 313 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027870 Css NA 94.8 mg/L PBTK NA 50% Rat Human -DTXSID8027870 Css NA 188.7 mg/L PBTK NA 95% Rat Human -DTXSID8027878 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027878 Fup NA 0.9132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027878 Vd NA 0.9565 L/kg 1compartment NA NA Human Human -DTXSID8027878 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027878 TK.Half.Life NA 6.856 hours 1compartment NA NA Human Human -DTXSID8027878 Css NA 0.8476 mg/L 3compartmentss NA 50% Human Human -DTXSID8027878 Css NA 3.282 mg/L 3compartmentss NA 95% Human Human -DTXSID8027878 Css NA 0.7407 mg/L PBTK NA 50% Human Human -DTXSID8027878 Css NA 2.316 mg/L PBTK NA 95% Human Human -DTXSID8027878 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027878 Fup NA 0.9132 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027878 Vd NA 0.9565 L/kg 1compartment NA NA Rat Human -DTXSID8027878 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027878 TK.Half.Life NA 2.316 hours 1compartment NA NA Rat Human -DTXSID8027878 Css NA 0.2154 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027878 Css NA 0.7723 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027878 Css NA 0.1847 mg/L PBTK NA 50% Rat Human -DTXSID8027878 Css NA 0.5064 mg/L PBTK NA 95% Rat Human -DTXSID8027905 Clint NA 30.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027905 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027905 Vd NA 2.933 L/kg 1compartment NA NA Human Human -DTXSID8027905 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8027905 TK.Half.Life NA 20.6 hours 1compartment NA NA Human Human -DTXSID8027905 Css NA 0.8153 mg/L 3compartmentss NA 50% Human Human -DTXSID8027905 Css NA 5.275 mg/L 3compartmentss NA 95% Human Human -DTXSID8027905 Css NA 0.564 mg/L PBTK NA 50% Human Human -DTXSID8027905 Css NA 3.49 mg/L PBTK NA 95% Human Human -DTXSID8027905 Clint NA 30.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027905 Fup NA 0.0743 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027905 Vd NA 2.202 L/kg 1compartment NA NA Rat Human -DTXSID8027905 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8027905 TK.Half.Life NA 3.825 hours 1compartment NA NA Rat Human -DTXSID8027905 Css NA 0.4571 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027905 Css NA 2.323 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027905 Css NA 0.302 mg/L PBTK NA 50% Rat Human -DTXSID8027905 Css NA 1.501 mg/L PBTK NA 95% Rat Human -DTXSID8027955 Clint NA 0.7402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027955 Fup NA 0.1111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027955 Vd NA 2.978 L/kg 1compartment NA NA Human Human -DTXSID8027955 Days.Css NA 119 Days PBTK NA NA Human Human -DTXSID8027955 TK.Half.Life NA 507.1 hours 1compartment NA NA Human Human -DTXSID8027955 Css NA 21.04 mg/L 3compartmentss NA 50% Human Human -DTXSID8027955 Css NA 73.26 mg/L 3compartmentss NA 95% Human Human -DTXSID8027955 Css NA 14.7 mg/L PBTK NA 50% Human Human -DTXSID8027955 Css NA 49.13 mg/L PBTK NA 95% Human Human -DTXSID8027955 Clint NA 0.7402 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027955 Fup NA 0.1111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027955 Vd NA 2.238 L/kg 1compartment NA NA Rat Human -DTXSID8027955 Days.Css NA 49 Days PBTK NA NA Rat Human -DTXSID8027955 TK.Half.Life NA 64.36 hours 1compartment NA NA Rat Human -DTXSID8027955 Css NA 9.191 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027955 Css NA 23.37 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027955 Css NA 6.154 mg/L PBTK NA 50% Rat Human -DTXSID8027955 Css NA 14.45 mg/L PBTK NA 95% Rat Human -DTXSID8027959 Clint NA 10.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027959 Fup NA 0.3609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8027959 Vd NA 1.557 L/kg 1compartment NA NA Human Human +DTXSID8027826 TK.Half.Life NA 3.224 hours 1compartment NA NA Rat Human +DTXSID8027826 Css NA 0.006794 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027826 Css NA 0.02953 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027826 Css NA 0.004588 mg/L PBTK NA 50% Rat Human +DTXSID8027826 Css NA 0.01789 mg/L PBTK NA 95% Rat Human +DTXSID8027959 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027959 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8027959 Vd NA 2.121 L/kg 1compartment NA NA Human Human DTXSID8027959 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8027959 TK.Half.Life NA 2.522 hours 1compartment NA NA Human Human -DTXSID8027959 Css NA 0.1093 mg/L 3compartmentss NA 50% Human Human -DTXSID8027959 Css NA 0.7962 mg/L 3compartmentss NA 95% Human Human -DTXSID8027959 Css NA 0.09002 mg/L PBTK NA 50% Human Human -DTXSID8027959 Css NA 0.5746 mg/L PBTK NA 95% Human Human -DTXSID8027959 Clint NA 10.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027959 Fup NA 0.3609 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8027959 Vd NA 1.407 L/kg 1compartment NA NA Rat Human +DTXSID8027959 TK.Half.Life NA 2.238 hours 1compartment NA NA Human Human +DTXSID8027959 Css NA 0.04606 mg/L 3compartmentss NA 50% Human Human +DTXSID8027959 Css NA 0.3951 mg/L 3compartmentss NA 95% Human Human +DTXSID8027959 Css NA 0.04058 mg/L PBTK NA 50% Human Human +DTXSID8027959 Css NA 0.2922 mg/L PBTK NA 95% Human Human +DTXSID8027959 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027959 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8027959 Vd NA 1.859 L/kg 1compartment NA NA Rat Human DTXSID8027959 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8027959 TK.Half.Life NA 1.206 hours 1compartment NA NA Rat Human -DTXSID8027959 Css NA 0.05687 mg/L 3compartmentss NA 50% Rat Human -DTXSID8027959 Css NA 0.3042 mg/L 3compartmentss NA 95% Rat Human -DTXSID8027959 Css NA 0.04542 mg/L PBTK NA 50% Rat Human -DTXSID8027959 Css NA 0.2074 mg/L PBTK NA 95% Rat Human -DTXSID8028842 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8028842 Fup NA 0.7127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8028842 Vd NA 0.5593 L/kg 1compartment NA NA Human Human -DTXSID8028842 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8028842 TK.Half.Life NA 5.078 hours 1compartment NA NA Human Human -DTXSID8028842 Css NA 1.123 mg/L 3compartmentss NA 50% Human Human -DTXSID8028842 Css NA 6.899 mg/L 3compartmentss NA 95% Human Human -DTXSID8028842 Css NA 0.8717 mg/L PBTK NA 50% Human Human -DTXSID8028842 Css NA 4.328 mg/L PBTK NA 95% Human Human -DTXSID8028842 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8028842 Fup NA 0.7127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8028842 Vd NA 0.6024 L/kg 1compartment NA NA Rat Human -DTXSID8028842 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8028842 TK.Half.Life NA 1.863 hours 1compartment NA NA Rat Human -DTXSID8028842 Css NA 0.292 mg/L 3compartmentss NA 50% Rat Human -DTXSID8028842 Css NA 1.84 mg/L 3compartmentss NA 95% Rat Human -DTXSID8028842 Css NA 0.2184 mg/L PBTK NA 50% Rat Human -DTXSID8028842 Css NA 1.071 mg/L PBTK NA 95% Rat Human -DTXSID8029072 Clint NA 0.007143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029072 Fup NA 0.2579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029072 Vd NA 0.3563 L/kg 1compartment NA NA Human Human -DTXSID8029072 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8029072 TK.Half.Life NA 8.833 hours 1compartment NA NA Human Human -DTXSID8029072 Css NA 2.968 mg/L 3compartmentss NA 50% Human Human -DTXSID8029072 Css NA 11.3 mg/L 3compartmentss NA 95% Human Human -DTXSID8029072 Css NA 1.99 mg/L PBTK NA 50% Human Human -DTXSID8029072 Css NA 6.883 mg/L PBTK NA 95% Human Human -DTXSID8029072 Clint NA 0.007143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029072 Fup NA 0.2579 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029072 Vd NA 0.3573 L/kg 1compartment NA NA Rat Human +DTXSID8027959 TK.Half.Life NA 0.933 hours 1compartment NA NA Rat Human +DTXSID8027959 Css NA 0.005622 mg/L 3compartmentss NA 50% Rat Human +DTXSID8027959 Css NA 0.03707 mg/L 3compartmentss NA 95% Rat Human +DTXSID8027959 Css NA 0.005017 mg/L PBTK NA 50% Rat Human +DTXSID8027959 Css NA 0.02712 mg/L PBTK NA 95% Rat Human +DTXSID80280666 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80280666 Fup 0.0693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80280666 Vd NA 2.517 L/kg 1compartment NA NA Human Human +DTXSID80280666 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID80280666 TK.Half.Life NA 14.55 hours 1compartment NA NA Human Human +DTXSID80280666 Css NA 0.6322 mg/L 3compartmentss NA 50% Human Human +DTXSID80280666 Css NA 4.089 mg/L 3compartmentss NA 95% Human Human +DTXSID80280666 Css NA 0.4298 mg/L PBTK NA 50% Human Human +DTXSID80280666 Css NA 2.708 mg/L PBTK NA 95% Human Human +DTXSID80280666 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80280666 Fup 0.0693 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80280666 Vd NA 1.89 L/kg 1compartment NA NA Rat Human +DTXSID80280666 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80280666 TK.Half.Life NA 3.705 hours 1compartment NA NA Rat Human +DTXSID80280666 Css NA 0.081 mg/L 3compartmentss NA 50% Rat Human +DTXSID80280666 Css NA 0.4087 mg/L 3compartmentss NA 95% Rat Human +DTXSID80280666 Css NA 0.05481 mg/L PBTK NA 50% Rat Human +DTXSID80280666 Css NA 0.2714 mg/L PBTK NA 95% Rat Human +DTXSID8029072 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029072 Fup 0.345 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029072 Vd NA 0.5549 L/kg 1compartment NA NA Human Human +DTXSID8029072 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8029072 TK.Half.Life NA 10.41 hours 1compartment NA NA Human Human +DTXSID8029072 Css NA 1.103 mg/L 3compartmentss NA 50% Human Human +DTXSID8029072 Css NA 4.946 mg/L 3compartmentss NA 95% Human Human +DTXSID8029072 Css NA 0.8272 mg/L PBTK NA 50% Human Human +DTXSID8029072 Css NA 3.225 mg/L PBTK NA 95% Human Human +DTXSID8029072 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029072 Fup 0.345 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029072 Vd NA 0.5596 L/kg 1compartment NA NA Rat Human DTXSID8029072 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029072 TK.Half.Life NA 3.037 hours 1compartment NA NA Rat Human -DTXSID8029072 Css NA 0.844 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029072 Css NA 2.721 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029072 Css NA 0.535 mg/L PBTK NA 50% Rat Human -DTXSID8029072 Css NA 1.557 mg/L PBTK NA 95% Rat Human -DTXSID8029105 Clint NA 0.9018 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029105 Fup NA 0.4973 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029105 Vd NA 0.8258 L/kg 1compartment NA NA Human Human +DTXSID8029072 TK.Half.Life NA 3.575 hours 1compartment NA NA Rat Human +DTXSID8029072 Css NA 0.005956 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029072 Css NA 0.02678 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029072 Css NA 0.004264 mg/L PBTK NA 50% Rat Human +DTXSID8029072 Css NA 0.01673 mg/L PBTK NA 95% Rat Human +DTXSID8029105 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029105 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029105 Vd NA 0.7389 L/kg 1compartment NA NA Human Human DTXSID8029105 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8029105 TK.Half.Life NA 4.584 hours 1compartment NA NA Human Human -DTXSID8029105 Css NA 0.5696 mg/L 3compartmentss NA 50% Human Human -DTXSID8029105 Css NA 3.371 mg/L 3compartmentss NA 95% Human Human -DTXSID8029105 Css NA 0.4542 mg/L PBTK NA 50% Human Human -DTXSID8029105 Css NA 2.184 mg/L PBTK NA 95% Human Human -DTXSID8029105 Clint NA 0.9018 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029105 Fup NA 0.4973 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029105 Vd NA 0.7845 L/kg 1compartment NA NA Rat Human +DTXSID8029105 TK.Half.Life NA 1.47 hours 1compartment NA NA Human Human +DTXSID8029105 Css NA 0.1584 mg/L 3compartmentss NA 50% Human Human +DTXSID8029105 Css NA 1.043 mg/L 3compartmentss NA 95% Human Human +DTXSID8029105 Css NA 0.1194 mg/L PBTK NA 50% Human Human +DTXSID8029105 Css NA 0.6976 mg/L PBTK NA 95% Human Human +DTXSID8029105 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029105 Fup 0.411 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029105 Vd NA 0.7013 L/kg 1compartment NA NA Rat Human DTXSID8029105 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029105 TK.Half.Life NA 2.059 hours 1compartment NA NA Rat Human -DTXSID8029105 Css NA 0.2194 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029105 Css NA 1.114 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029105 Css NA 0.1698 mg/L PBTK NA 50% Rat Human -DTXSID8029105 Css NA 0.67 mg/L PBTK NA 95% Rat Human -DTXSID8029153 Clint NA 23.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029153 Fup NA 0.0487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029153 Vd NA 2.669 L/kg 1compartment NA NA Human Human -DTXSID8029153 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8029153 TK.Half.Life NA 20.93 hours 1compartment NA NA Human Human -DTXSID8029153 Css NA 1 mg/L 3compartmentss NA 50% Human Human -DTXSID8029153 Css NA 6.813 mg/L 3compartmentss NA 95% Human Human -DTXSID8029153 Css NA 0.6782 mg/L PBTK NA 50% Human Human -DTXSID8029153 Css NA 4.413 mg/L PBTK NA 95% Human Human -DTXSID8029153 Clint NA 23.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029153 Fup NA 0.0487 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029153 Vd NA 1.999 L/kg 1compartment NA NA Rat Human +DTXSID8029105 TK.Half.Life NA 0.7723 hours 1compartment NA NA Rat Human +DTXSID8029105 Css NA 0.01828 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029105 Css NA 0.09247 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029105 Css NA 0.01373 mg/L PBTK NA 50% Rat Human +DTXSID8029105 Css NA 0.05975 mg/L PBTK NA 95% Rat Human +DTXSID8029153 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029153 Fup 0.0228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029153 Vd NA 2.292 L/kg 1compartment NA NA Human Human +DTXSID8029153 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8029153 TK.Half.Life NA 23.83 hours 1compartment NA NA Human Human +DTXSID8029153 Css NA 1.49 mg/L 3compartmentss NA 50% Human Human +DTXSID8029153 Css NA 11.17 mg/L 3compartmentss NA 95% Human Human +DTXSID8029153 Css NA 0.9726 mg/L PBTK NA 50% Human Human +DTXSID8029153 Css NA 6.95 mg/L PBTK NA 95% Human Human +DTXSID8029153 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029153 Fup 0.0228 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029153 Vd NA 1.708 L/kg 1compartment NA NA Rat Human DTXSID8029153 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8029153 TK.Half.Life NA 4.735 hours 1compartment NA NA Rat Human -DTXSID8029153 Css NA 0.5572 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029153 Css NA 3 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029153 Css NA 0.3591 mg/L PBTK NA 50% Rat Human -DTXSID8029153 Css NA 1.838 mg/L PBTK NA 95% Rat Human -DTXSID8029157 Clint NA 12.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029157 Fup NA 0.0664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029157 Vd NA 2.796 L/kg 1compartment NA NA Human Human -DTXSID8029157 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8029157 TK.Half.Life NA 37.43 hours 1compartment NA NA Human Human -DTXSID8029157 Css NA 1.716 mg/L 3compartmentss NA 50% Human Human -DTXSID8029157 Css NA 10.41 mg/L 3compartmentss NA 95% Human Human -DTXSID8029157 Css NA 1.18 mg/L PBTK NA 50% Human Human -DTXSID8029157 Css NA 6.853 mg/L PBTK NA 95% Human Human -DTXSID8029157 Clint NA 12.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029157 Fup NA 0.0664 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029157 Vd NA 2.098 L/kg 1compartment NA NA Rat Human -DTXSID8029157 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8029157 TK.Half.Life NA 7.412 hours 1compartment NA NA Rat Human -DTXSID8029157 Css NA 0.9402 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029157 Css NA 4.335 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029157 Css NA 0.6161 mg/L PBTK NA 50% Rat Human -DTXSID8029157 Css NA 2.747 mg/L PBTK NA 95% Rat Human -DTXSID8029159 Clint NA 51.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029159 Fup NA 0.0701 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029159 Vd NA 3.069 L/kg 1compartment NA NA Human Human +DTXSID8029153 TK.Half.Life NA 6.678 hours 1compartment NA NA Rat Human +DTXSID8029153 Css NA 0.1895 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029153 Css NA 1.234 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029153 Css NA 0.1218 mg/L PBTK NA 50% Rat Human +DTXSID8029153 Css NA 0.7571 mg/L PBTK NA 95% Rat Human +DTXSID8029157 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029157 Fup 0.0144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029157 Vd NA 2.806 L/kg 1compartment NA NA Human Human +DTXSID8029157 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8029157 TK.Half.Life NA 50.34 hours 1compartment NA NA Human Human +DTXSID8029157 Css NA 2.352 mg/L 3compartmentss NA 50% Human Human +DTXSID8029157 Css NA 16.57 mg/L 3compartmentss NA 95% Human Human +DTXSID8029157 Css NA 1.588 mg/L PBTK NA 50% Human Human +DTXSID8029157 Css NA 10.67 mg/L PBTK NA 95% Human Human +DTXSID8029157 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029157 Fup 0.0144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029157 Vd NA 2.097 L/kg 1compartment NA NA Rat Human +DTXSID8029157 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8029157 TK.Half.Life NA 9.761 hours 1compartment NA NA Rat Human +DTXSID8029157 Css NA 0.3076 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029157 Css NA 1.795 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029157 Css NA 0.205 mg/L PBTK NA 50% Rat Human +DTXSID8029157 Css NA 1.17 mg/L PBTK NA 95% Rat Human +DTXSID8029159 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029159 Fup 0.0646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029159 Vd NA 2.704 L/kg 1compartment NA NA Human Human DTXSID8029159 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8029159 TK.Half.Life NA 21.66 hours 1compartment NA NA Human Human -DTXSID8029159 Css NA 0.7904 mg/L 3compartmentss NA 50% Human Human -DTXSID8029159 Css NA 5.049 mg/L 3compartmentss NA 95% Human Human -DTXSID8029159 Css NA 0.5476 mg/L PBTK NA 50% Human Human -DTXSID8029159 Css NA 3.312 mg/L PBTK NA 95% Human Human -DTXSID8029159 Clint NA 51.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029159 Fup NA 0.0701 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029159 Vd NA 2.301 L/kg 1compartment NA NA Rat Human +DTXSID8029159 TK.Half.Life NA 19.65 hours 1compartment NA NA Human Human +DTXSID8029159 Css NA 0.8521 mg/L 3compartmentss NA 50% Human Human +DTXSID8029159 Css NA 5.459 mg/L 3compartmentss NA 95% Human Human +DTXSID8029159 Css NA 0.5812 mg/L PBTK NA 50% Human Human +DTXSID8029159 Css NA 3.61 mg/L PBTK NA 95% Human Human +DTXSID8029159 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029159 Fup 0.0646 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029159 Vd NA 2.03 L/kg 1compartment NA NA Rat Human DTXSID8029159 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8029159 TK.Half.Life NA 3.508 hours 1compartment NA NA Rat Human -DTXSID8029159 Css NA 0.4399 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029159 Css NA 2.361 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029159 Css NA 0.2926 mg/L PBTK NA 50% Rat Human -DTXSID8029159 Css NA 1.511 mg/L PBTK NA 95% Rat Human +DTXSID8029159 TK.Half.Life NA 4.365 hours 1compartment NA NA Rat Human +DTXSID8029159 Css NA 0.1116 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029159 Css NA 0.5871 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029159 Css NA 0.07492 mg/L PBTK NA 50% Rat Human +DTXSID8029159 Css NA 0.3832 mg/L PBTK NA 95% Rat Human DTXSID8029230 Clint NA 0.004913 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8029230 Fup NA 0.8053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029230 Vd NA 2.714 L/kg 1compartment NA NA Human Human +DTXSID8029230 Vd NA 2.287 L/kg 1compartment NA NA Human Human DTXSID8029230 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8029230 TK.Half.Life NA 21.63 hours 1compartment NA NA Human Human -DTXSID8029230 Css NA 0.709 mg/L 3compartmentss NA 50% Human Human -DTXSID8029230 Css NA 5.013 mg/L 3compartmentss NA 95% Human Human -DTXSID8029230 Css NA 0.8118 mg/L PBTK NA 50% Human Human -DTXSID8029230 Css NA 3.713 mg/L PBTK NA 95% Human Human +DTXSID8029230 TK.Half.Life NA 18.23 hours 1compartment NA NA Human Human +DTXSID8029230 Css NA 0.6349 mg/L 3compartmentss NA 50% Human Human +DTXSID8029230 Css NA 4.523 mg/L 3compartmentss NA 95% Human Human +DTXSID8029230 Css NA 0.68 mg/L PBTK NA 50% Human Human +DTXSID8029230 Css NA 3.284 mg/L PBTK NA 95% Human Human DTXSID8029230 Clint NA 0.004913 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8029230 Fup NA 0.8053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029230 Vd NA 2.744 L/kg 1compartment NA NA Rat Human +DTXSID8029230 Vd NA 2.31 L/kg 1compartment NA NA Rat Human DTXSID8029230 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029230 TK.Half.Life NA 7.485 hours 1compartment NA NA Rat Human -DTXSID8029230 Css NA 0.176 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029230 Css NA 1.321 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029230 Css NA 0.2007 mg/L PBTK NA 50% Rat Human -DTXSID8029230 Css NA 0.8925 mg/L PBTK NA 95% Rat Human +DTXSID8029230 TK.Half.Life NA 6.301 hours 1compartment NA NA Rat Human +DTXSID8029230 Css NA 0.01194 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029230 Css NA 0.1076 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029230 Css NA 0.01262 mg/L PBTK NA 50% Rat Human +DTXSID8029230 Css NA 0.07863 mg/L PBTK NA 95% Rat Human DTXSID8029232 Clint NA 0.6723 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8029232 Fup NA 0.7305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029232 Vd NA 0.5593 L/kg 1compartment NA NA Human Human +DTXSID8029232 Vd NA 0.5518 L/kg 1compartment NA NA Human Human DTXSID8029232 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8029232 TK.Half.Life NA 2.28 hours 1compartment NA NA Human Human -DTXSID8029232 Css NA 0.4857 mg/L 3compartmentss NA 50% Human Human -DTXSID8029232 Css NA 3.127 mg/L 3compartmentss NA 95% Human Human -DTXSID8029232 Css NA 0.3771 mg/L PBTK NA 50% Human Human -DTXSID8029232 Css NA 1.964 mg/L PBTK NA 95% Human Human +DTXSID8029232 TK.Half.Life NA 0.4332 hours 1compartment NA NA Human Human +DTXSID8029232 Css NA 0.01426 mg/L 3compartmentss NA 50% Human Human +DTXSID8029232 Css NA 0.1792 mg/L 3compartmentss NA 95% Human Human +DTXSID8029232 Css NA 0.01089 mg/L PBTK NA 50% Human Human +DTXSID8029232 Css NA 0.1253 mg/L PBTK NA 95% Human Human DTXSID8029232 Clint NA 0.6723 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8029232 Fup NA 0.7305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029232 Vd NA 0.6047 L/kg 1compartment NA NA Rat Human +DTXSID8029232 Vd NA 0.5989 L/kg 1compartment NA NA Rat Human DTXSID8029232 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029232 TK.Half.Life NA 1.148 hours 1compartment NA NA Rat Human -DTXSID8029232 Css NA 0.177 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029232 Css NA 1.096 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029232 Css NA 0.1339 mg/L PBTK NA 50% Rat Human -DTXSID8029232 Css NA 0.643 mg/L PBTK NA 95% Rat Human -DTXSID8029236 Clint NA 5.815 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029236 Fup NA 0.013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029236 Vd NA 10.36 L/kg 1compartment NA NA Human Human -DTXSID8029236 Days.Css NA 286 Days PBTK NA NA Human Human -DTXSID8029236 TK.Half.Life NA 1141 hours 1compartment NA NA Human Human -DTXSID8029236 Css NA 7.437 mg/L 3compartmentss NA 50% Human Human -DTXSID8029236 Css NA 44.3 mg/L 3compartmentss NA 95% Human Human -DTXSID8029236 Css NA 9.022 mg/L PBTK NA 50% Human Human -DTXSID8029236 Css NA 52.74 mg/L PBTK NA 95% Human Human -DTXSID8029236 Clint NA 5.815 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029236 Fup NA 0.013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029236 Vd NA 8.167 L/kg 1compartment NA NA Rat Human -DTXSID8029236 Days.Css NA 163 Days PBTK NA NA Rat Human -DTXSID8029236 TK.Half.Life NA 156.3 hours 1compartment NA NA Rat Human -DTXSID8029236 Css NA 4.044 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029236 Css NA 16.58 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029236 Css NA 4.901 mg/L PBTK NA 50% Rat Human -DTXSID8029236 Css NA 19.85 mg/L PBTK NA 95% Rat Human -DTXSID8029280 Clint NA 12.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029280 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029280 Vd NA 0.6415 L/kg 1compartment NA NA Human Human +DTXSID8029232 TK.Half.Life NA 0.2207 hours 1compartment NA NA Rat Human +DTXSID8029232 Css NA 0.0005111 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029232 Css NA 0.007227 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029232 Css NA 0.0003847 mg/L PBTK NA 50% Rat Human +DTXSID8029232 Css NA 0.004669 mg/L PBTK NA 95% Rat Human +DTXSID8029280 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029280 Fup 0.717 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029280 Vd NA 0.5304 L/kg 1compartment NA NA Human Human DTXSID8029280 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8029280 TK.Half.Life NA 0.5239 hours 1compartment NA NA Human Human -DTXSID8029280 Css NA 0.04 mg/L 3compartmentss NA 50% Human Human -DTXSID8029280 Css NA 0.4443 mg/L 3compartmentss NA 95% Human Human -DTXSID8029280 Css NA 0.03204 mg/L PBTK NA 50% Human Human -DTXSID8029280 Css NA 0.3277 mg/L PBTK NA 95% Human Human -DTXSID8029280 Clint NA 12.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029280 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029280 Vd NA 0.6656 L/kg 1compartment NA NA Rat Human +DTXSID8029280 TK.Half.Life NA 4.787 hours 1compartment NA NA Human Human +DTXSID8029280 Css NA 1.098 mg/L 3compartmentss NA 50% Human Human +DTXSID8029280 Css NA 6.664 mg/L 3compartmentss NA 95% Human Human +DTXSID8029280 Css NA 0.8453 mg/L PBTK NA 50% Human Human +DTXSID8029280 Css NA 4.193 mg/L PBTK NA 95% Human Human +DTXSID8029280 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029280 Fup 0.717 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029280 Vd NA 0.5494 L/kg 1compartment NA NA Rat Human DTXSID8029280 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029280 TK.Half.Life NA 0.2664 hours 1compartment NA NA Rat Human -DTXSID8029280 Css NA 0.01987 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029280 Css NA 0.1702 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029280 Css NA 0.01566 mg/L PBTK NA 50% Rat Human -DTXSID8029280 Css NA 0.1113 mg/L PBTK NA 95% Rat Human -DTXSID8029282 Clint NA 139.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029282 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029282 Vd NA 2.15 L/kg 1compartment NA NA Human Human -DTXSID8029282 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8029282 TK.Half.Life NA 5.157 hours 1compartment NA NA Human Human -DTXSID8029282 Css NA 0.2468 mg/L 3compartmentss NA 50% Human Human -DTXSID8029282 Css NA 2.089 mg/L 3compartmentss NA 95% Human Human -DTXSID8029282 Css NA 0.1604 mg/L PBTK NA 50% Human Human -DTXSID8029282 Css NA 1.28 mg/L PBTK NA 95% Human Human -DTXSID8029282 Clint NA 139.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029282 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029282 Vd NA 1.599 L/kg 1compartment NA NA Rat Human -DTXSID8029282 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029282 TK.Half.Life NA 1.602 hours 1compartment NA NA Rat Human -DTXSID8029282 Css NA 0.1416 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029282 Css NA 0.998 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029282 Css NA 0.08664 mg/L PBTK NA 50% Rat Human -DTXSID8029282 Css NA 0.5839 mg/L PBTK NA 95% Rat Human -DTXSID8029315 Clint NA 37.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029315 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029315 Vd NA 13.11 L/kg 1compartment NA NA Human Human -DTXSID8029315 Days.Css NA 44 Days PBTK NA NA Human Human -DTXSID8029315 TK.Half.Life NA 229.2 hours 1compartment NA NA Human Human -DTXSID8029315 Css NA 0.9714 mg/L 3compartmentss NA 50% Human Human -DTXSID8029315 Css NA 5.529 mg/L 3compartmentss NA 95% Human Human -DTXSID8029315 Css NA 1.415 mg/L PBTK NA 50% Human Human -DTXSID8029315 Css NA 7.855 mg/L PBTK NA 95% Human Human -DTXSID8029315 Clint NA 37.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029315 Fup NA 0.0118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029315 Vd NA 10.44 L/kg 1compartment NA NA Rat Human -DTXSID8029315 Days.Css NA 27 Days PBTK NA NA Rat Human -DTXSID8029315 TK.Half.Life NA 32.7 hours 1compartment NA NA Rat Human -DTXSID8029315 Css NA 0.5208 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029315 Css NA 2.314 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029315 Css NA 0.7708 mg/L PBTK NA 50% Rat Human -DTXSID8029315 Css NA 3.399 mg/L PBTK NA 95% Rat Human -DTXSID8029317 Clint NA 12.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029317 Fup NA 0.2141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029317 Vd NA 2.476 L/kg 1compartment NA NA Human Human -DTXSID8029317 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8029317 TK.Half.Life NA 9.529 hours 1compartment NA NA Human Human -DTXSID8029317 Css NA 0.3726 mg/L 3compartmentss NA 50% Human Human -DTXSID8029317 Css NA 2.299 mg/L 3compartmentss NA 95% Human Human -DTXSID8029317 Css NA 0.2711 mg/L PBTK NA 50% Human Human -DTXSID8029317 Css NA 1.568 mg/L PBTK NA 95% Human Human -DTXSID8029317 Clint NA 12.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029317 Fup NA 0.2141 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029317 Vd NA 1.89 L/kg 1compartment NA NA Rat Human -DTXSID8029317 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029317 TK.Half.Life NA 2.585 hours 1compartment NA NA Rat Human -DTXSID8029317 Css NA 0.2026 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029317 Css NA 0.9019 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029317 Css NA 0.1414 mg/L PBTK NA 50% Rat Human -DTXSID8029317 Css NA 0.5945 mg/L PBTK NA 95% Rat Human -DTXSID8029369 Clint NA 43.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029369 Fup NA 0.0822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029369 Vd NA 3.007 L/kg 1compartment NA NA Human Human -DTXSID8029369 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8029369 TK.Half.Life NA 18.2 hours 1compartment NA NA Human Human -DTXSID8029369 Css NA 0.6717 mg/L 3compartmentss NA 50% Human Human -DTXSID8029369 Css NA 4.314 mg/L 3compartmentss NA 95% Human Human -DTXSID8029369 Css NA 0.4658 mg/L PBTK NA 50% Human Human -DTXSID8029369 Css NA 2.927 mg/L PBTK NA 95% Human Human -DTXSID8029369 Clint NA 43.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029369 Fup NA 0.0822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029369 Vd NA 2.257 L/kg 1compartment NA NA Rat Human -DTXSID8029369 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029369 TK.Half.Life NA 3.206 hours 1compartment NA NA Rat Human -DTXSID8029369 Css NA 0.3799 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029369 Css NA 2.027 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029369 Css NA 0.2527 mg/L PBTK NA 50% Rat Human -DTXSID8029369 Css NA 1.314 mg/L PBTK NA 95% Rat Human -DTXSID8029575 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029575 Fup NA 0.4384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029575 Vd NA 2.841 L/kg 1compartment NA NA Human Human -DTXSID8029575 Days.Css NA 42 Days PBTK NA NA Human Human -DTXSID8029575 TK.Half.Life NA 203.2 hours 1compartment NA NA Human Human -DTXSID8029575 Css NA 7.677 mg/L 3compartmentss NA 50% Human Human -DTXSID8029575 Css NA 23.06 mg/L 3compartmentss NA 95% Human Human -DTXSID8029575 Css NA 5.862 mg/L PBTK NA 50% Human Human -DTXSID8029575 Css NA 15.59 mg/L PBTK NA 95% Human Human -DTXSID8029575 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029575 Fup NA 0.4384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029575 Vd NA 2.178 L/kg 1compartment NA NA Rat Human -DTXSID8029575 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID8029575 TK.Half.Life NA 21 hours 1compartment NA NA Rat Human -DTXSID8029575 Css NA 2.069 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029575 Css NA 5.017 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029575 Css NA 1.522 mg/L PBTK NA 50% Rat Human -DTXSID8029575 Css NA 3.179 mg/L PBTK NA 95% Rat Human +DTXSID8029280 TK.Half.Life NA 1.689 hours 1compartment NA NA Rat Human +DTXSID8029280 Css NA 0.0653 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029280 Css NA 0.4063 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029280 Css NA 0.05031 mg/L PBTK NA 50% Rat Human +DTXSID8029280 Css NA 0.2449 mg/L PBTK NA 95% Rat Human +DTXSID8029282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029282 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029282 Vd NA 1.729 L/kg 1compartment NA NA Human Human +DTXSID8029282 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8029282 TK.Half.Life NA 25.29 hours 1compartment NA NA Human Human +DTXSID8029282 Css NA 2.326 mg/L 3compartmentss NA 50% Human Human +DTXSID8029282 Css NA 20.29 mg/L 3compartmentss NA 95% Human Human +DTXSID8029282 Css NA 1.463 mg/L PBTK NA 50% Human Human +DTXSID8029282 Css NA 12.38 mg/L PBTK NA 95% Human Human +DTXSID8029282 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029282 Fup 0.0106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029282 Vd NA 1.278 L/kg 1compartment NA NA Rat Human +DTXSID8029282 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8029282 TK.Half.Life NA 9.021 hours 1compartment NA NA Rat Human +DTXSID8029282 Css NA 0.3004 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029282 Css NA 2.201 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029282 Css NA 0.1834 mg/L PBTK NA 50% Rat Human +DTXSID8029282 Css NA 1.278 mg/L PBTK NA 95% Rat Human +DTXSID8029286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029286 Fup 0.00727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029286 Vd NA 3.098 L/kg 1compartment NA NA Human Human +DTXSID8029286 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID8029286 TK.Half.Life NA 94.23 hours 1compartment NA NA Human Human +DTXSID8029286 Css NA 3.471 mg/L 3compartmentss NA 50% Human Human +DTXSID8029286 Css NA 20.86 mg/L 3compartmentss NA 95% Human Human +DTXSID8029286 Css NA 2.42 mg/L PBTK NA 50% Human Human +DTXSID8029286 Css NA 14.36 mg/L PBTK NA 95% Human Human +DTXSID8029286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029286 Fup 0.00727 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029286 Vd NA 2.321 L/kg 1compartment NA NA Rat Human +DTXSID8029286 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID8029286 TK.Half.Life NA 13.04 hours 1compartment NA NA Rat Human +DTXSID8029286 Css NA 0.4598 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029286 Css NA 2.267 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029286 Css NA 0.3133 mg/L PBTK NA 50% Rat Human +DTXSID8029286 Css NA 1.569 mg/L PBTK NA 95% Rat Human +DTXSID8029575 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029575 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029575 Vd NA 2.332 L/kg 1compartment NA NA Human Human +DTXSID8029575 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8029575 TK.Half.Life NA 3.868 hours 1compartment NA NA Human Human +DTXSID8029575 Css NA 0.1095 mg/L 3compartmentss NA 50% Human Human +DTXSID8029575 Css NA 0.7204 mg/L 3compartmentss NA 95% Human Human +DTXSID8029575 Css NA 0.08375 mg/L PBTK NA 50% Human Human +DTXSID8029575 Css NA 0.5119 mg/L PBTK NA 95% Human Human +DTXSID8029575 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029575 Fup 0.338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029575 Vd NA 1.812 L/kg 1compartment NA NA Rat Human +DTXSID8029575 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8029575 TK.Half.Life NA 1.215 hours 1compartment NA NA Rat Human +DTXSID8029575 Css NA 0.01335 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029575 Css NA 0.06953 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029575 Css NA 0.01028 mg/L PBTK NA 50% Rat Human +DTXSID8029575 Css NA 0.04999 mg/L PBTK NA 95% Rat Human DTXSID8029600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8029600 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8029600 Vd NA 0.7777 L/kg 1compartment NA NA Human Human DTXSID8029600 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8029600 TK.Half.Life NA 5.034 hours 1compartment NA NA Human Human -DTXSID8029600 Css NA 0.8272 mg/L 3compartmentss NA 50% Human Human -DTXSID8029600 Css NA 5.561 mg/L 3compartmentss NA 95% Human Human -DTXSID8029600 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID8029600 Css NA 3.572 mg/L PBTK NA 95% Human Human +DTXSID8029600 Css NA 0.6996 mg/L 3compartmentss NA 50% Human Human +DTXSID8029600 Css NA 4.74 mg/L 3compartmentss NA 95% Human Human +DTXSID8029600 Css NA 0.5926 mg/L PBTK NA 50% Human Human +DTXSID8029600 Css NA 3.103 mg/L PBTK NA 95% Human Human DTXSID8029600 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8029600 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8029600 Vd NA 0.8154 L/kg 1compartment NA NA Rat Human DTXSID8029600 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8029600 TK.Half.Life NA 1.798 hours 1compartment NA NA Rat Human -DTXSID8029600 Css NA 0.2081 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029600 Css NA 1.329 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029600 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID8029600 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID8029602 Clint NA 219.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029602 Fup NA 0.0065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029602 Vd NA 92.99 L/kg 1compartment NA NA Human Human -DTXSID8029602 Days.Css NA 54 Days PBTK NA NA Human Human -DTXSID8029602 TK.Half.Life NA 277.9 hours 1compartment NA NA Human Human -DTXSID8029602 Css NA 0.02219 mg/L 3compartmentss NA 50% Human Human -DTXSID8029602 Css NA 0.138 mg/L 3compartmentss NA 95% Human Human -DTXSID8029602 Css NA 0.244 mg/L PBTK NA 50% Human Human -DTXSID8029602 Css NA 1.376 mg/L PBTK NA 95% Human Human -DTXSID8029602 Clint NA 219.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029602 Fup NA 0.0065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029602 Vd NA 80.18 L/kg 1compartment NA NA Rat Human -DTXSID8029602 Days.Css NA 37 Days PBTK NA NA Rat Human -DTXSID8029602 TK.Half.Life NA 43.76 hours 1compartment NA NA Rat Human -DTXSID8029602 Css NA 0.0113 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029602 Css NA 0.05048 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029602 Css NA 0.1335 mg/L PBTK NA 50% Rat Human -DTXSID8029602 Css NA 0.5829 mg/L PBTK NA 95% Rat Human -DTXSID8029604 Clint NA 0.6529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029604 Fup NA 0.8112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029604 Vd NA 1.204 L/kg 1compartment NA NA Human Human +DTXSID8029600 Css NA 0.01275 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029600 Css NA 0.09988 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029600 Css NA 0.01048 mg/L PBTK NA 50% Rat Human +DTXSID8029600 Css NA 0.06659 mg/L PBTK NA 95% Rat Human +DTXSID8029602 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029602 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029602 Vd NA 39.04 L/kg 1compartment NA NA Human Human +DTXSID8029602 Days.Css NA 285 Days PBTK NA NA Human Human +DTXSID8029602 TK.Half.Life NA 1154 hours 1compartment NA NA Human Human +DTXSID8029602 Css NA 0.5654 mg/L 3compartmentss NA 50% Human Human +DTXSID8029602 Css NA 3.607 mg/L 3compartmentss NA 95% Human Human +DTXSID8029602 Css NA 2.385 mg/L PBTK NA 50% Human Human +DTXSID8029602 Css NA 14.02 mg/L PBTK NA 95% Human Human +DTXSID8029602 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029602 Fup 0.0138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029602 Vd NA 32.6 L/kg 1compartment NA NA Rat Human +DTXSID8029602 Days.Css NA 176 Days PBTK NA NA Rat Human +DTXSID8029602 TK.Half.Life NA 167.3 hours 1compartment NA NA Rat Human +DTXSID8029602 Css NA 0.06685 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029602 Css NA 0.3396 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029602 Css NA 0.3062 mg/L PBTK NA 50% Rat Human +DTXSID8029602 Css NA 1.622 mg/L PBTK NA 95% Rat Human +DTXSID8029604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029604 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8029604 Vd NA 0.5259 L/kg 1compartment NA NA Human Human DTXSID8029604 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8029604 TK.Half.Life NA 5.023 hours 1compartment NA NA Human Human -DTXSID8029604 Css NA 0.444 mg/L 3compartmentss NA 50% Human Human -DTXSID8029604 Css NA 2.907 mg/L 3compartmentss NA 95% Human Human -DTXSID8029604 Css NA 0.3934 mg/L PBTK NA 50% Human Human -DTXSID8029604 Css NA 1.962 mg/L PBTK NA 95% Human Human -DTXSID8029604 Clint NA 0.6529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029604 Fup NA 0.8112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029604 Vd NA 1.128 L/kg 1compartment NA NA Rat Human +DTXSID8029604 TK.Half.Life NA 0.8979 hours 1compartment NA NA Human Human +DTXSID8029604 Css NA 0.1139 mg/L 3compartmentss NA 50% Human Human +DTXSID8029604 Css NA 0.8368 mg/L 3compartmentss NA 95% Human Human +DTXSID8029604 Css NA 0.07636 mg/L PBTK NA 50% Human Human +DTXSID8029604 Css NA 0.5344 mg/L PBTK NA 95% Human Human +DTXSID8029604 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029604 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8029604 Vd NA 0.4874 L/kg 1compartment NA NA Rat Human DTXSID8029604 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029604 TK.Half.Life NA 2.06 hours 1compartment NA NA Rat Human -DTXSID8029604 Css NA 0.1538 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029604 Css NA 0.9997 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029604 Css NA 0.1362 mg/L PBTK NA 50% Rat Human -DTXSID8029604 Css NA 0.6151 mg/L PBTK NA 95% Rat Human +DTXSID8029604 TK.Half.Life NA 0.4612 hours 1compartment NA NA Rat Human +DTXSID8029604 Css NA 0.01444 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029604 Css NA 0.07772 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029604 Css NA 0.009572 mg/L PBTK NA 50% Rat Human +DTXSID8029604 Css NA 0.04859 mg/L PBTK NA 95% Rat Human DTXSID8029606 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8029606 Fup NA 0.9185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029606 Vd NA 1.223 L/kg 1compartment NA NA Human Human +DTXSID8029606 Vd NA 1.059 L/kg 1compartment NA NA Human Human DTXSID8029606 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8029606 TK.Half.Life NA 9.042 hours 1compartment NA NA Human Human -DTXSID8029606 Css NA 0.8096 mg/L 3compartmentss NA 50% Human Human -DTXSID8029606 Css NA 3.117 mg/L 3compartmentss NA 95% Human Human -DTXSID8029606 Css NA 0.7401 mg/L PBTK NA 50% Human Human -DTXSID8029606 Css NA 2.3 mg/L PBTK NA 95% Human Human +DTXSID8029606 TK.Half.Life NA 7.629 hours 1compartment NA NA Human Human +DTXSID8029606 Css NA 0.7031 mg/L 3compartmentss NA 50% Human Human +DTXSID8029606 Css NA 2.728 mg/L 3compartmentss NA 95% Human Human +DTXSID8029606 Css NA 0.6271 mg/L PBTK NA 50% Human Human +DTXSID8029606 Css NA 1.98 mg/L PBTK NA 95% Human Human DTXSID8029606 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8029606 Fup NA 0.9185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029606 Vd NA 1.162 L/kg 1compartment NA NA Rat Human +DTXSID8029606 Vd NA 1.038 L/kg 1compartment NA NA Rat Human DTXSID8029606 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8029606 TK.Half.Life NA 2.822 hours 1compartment NA NA Rat Human -DTXSID8029606 Css NA 0.2074 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029606 Css NA 0.7721 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029606 Css NA 0.1869 mg/L PBTK NA 50% Rat Human -DTXSID8029606 Css NA 0.5175 mg/L PBTK NA 95% Rat Human -DTXSID8029650 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029650 Fup NA 0.2199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029650 Vd NA 2.753 L/kg 1compartment NA NA Human Human -DTXSID8029650 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8029650 TK.Half.Life NA 34.64 hours 1compartment NA NA Human Human -DTXSID8029650 Css NA 1.436 mg/L 3compartmentss NA 50% Human Human -DTXSID8029650 Css NA 6.845 mg/L 3compartmentss NA 95% Human Human -DTXSID8029650 Css NA 1.034 mg/L PBTK NA 50% Human Human -DTXSID8029650 Css NA 4.713 mg/L PBTK NA 95% Human Human -DTXSID8029650 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029650 Fup NA 0.2199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029650 Vd NA 2.089 L/kg 1compartment NA NA Rat Human -DTXSID8029650 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8029650 TK.Half.Life NA 6.999 hours 1compartment NA NA Rat Human -DTXSID8029650 Css NA 0.7258 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029650 Css NA 2.481 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029650 Css NA 0.5042 mg/L PBTK NA 50% Rat Human -DTXSID8029650 Css NA 1.629 mg/L PBTK NA 95% Rat Human -DTXSID8029733 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029733 Fup NA 0.2199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029733 Vd NA 2.753 L/kg 1compartment NA NA Human Human -DTXSID8029733 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8029733 TK.Half.Life NA 34.64 hours 1compartment NA NA Human Human -DTXSID8029733 Css NA 1.436 mg/L 3compartmentss NA 50% Human Human -DTXSID8029733 Css NA 6.845 mg/L 3compartmentss NA 95% Human Human -DTXSID8029733 Css NA 1.034 mg/L PBTK NA 50% Human Human -DTXSID8029733 Css NA 4.713 mg/L PBTK NA 95% Human Human -DTXSID8029733 Clint NA 4.267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029733 Fup NA 0.2199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029733 Vd NA 2.089 L/kg 1compartment NA NA Rat Human -DTXSID8029733 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8029733 TK.Half.Life NA 6.999 hours 1compartment NA NA Rat Human -DTXSID8029733 Css NA 0.7258 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029733 Css NA 2.481 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029733 Css NA 0.5042 mg/L PBTK NA 50% Rat Human -DTXSID8029733 Css NA 1.629 mg/L PBTK NA 95% Rat Human -DTXSID8029739 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029739 Fup NA 0.3474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8029739 Vd NA 3.285 L/kg 1compartment NA NA Human Human -DTXSID8029739 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID8029739 TK.Half.Life NA 155200 hours 1compartment NA NA Human Human -DTXSID8029739 Css NA 5138 mg/L 3compartmentss NA 50% Human Human -DTXSID8029739 Css NA 11530 mg/L 3compartmentss NA 95% Human Human -DTXSID8029739 Css NA 3625 mg/L PBTK NA 50% Human Human -DTXSID8029739 Css NA 7848 mg/L PBTK NA 95% Human Human -DTXSID8029739 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029739 Fup NA 0.3474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8029739 Vd NA 2.466 L/kg 1compartment NA NA Rat Human -DTXSID8029739 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID8029739 TK.Half.Life NA 9476 hours 1compartment NA NA Rat Human -DTXSID8029739 Css NA 1425 mg/L 3compartmentss NA 50% Rat Human -DTXSID8029739 Css NA 2072 mg/L 3compartmentss NA 95% Rat Human -DTXSID8029739 Css NA 964.6 mg/L PBTK NA 50% Rat Human -DTXSID8029739 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID8029606 TK.Half.Life NA 2.505 hours 1compartment NA NA Rat Human +DTXSID8029606 Css NA 0.01255 mg/L 3compartmentss NA 50% Rat Human +DTXSID8029606 Css NA 0.06948 mg/L 3compartmentss NA 95% Rat Human +DTXSID8029606 Css NA 0.01085 mg/L PBTK NA 50% Rat Human +DTXSID8029606 Css NA 0.0518 mg/L PBTK NA 95% Rat Human DTXSID8029868 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8029868 Fup 0.02 NA NA https://doi.org/10.1124/dmd.117.077040 NA Human Human -DTXSID8029868 Vd NA 11.48 L/kg 1compartment NA NA Human Human -DTXSID8029868 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID8029868 TK.Half.Life NA 531100 hours 1compartment NA NA Human Human -DTXSID8029868 Css NA 2700 mg/L 3compartmentss NA 50% Human Human -DTXSID8029868 Css NA 6592 mg/L 3compartmentss NA 95% Human Human -DTXSID8029868 Css NA 3570 mg/L PBTK NA 50% Human Human -DTXSID8029868 Css NA 7703 mg/L PBTK NA 95% Human Human +DTXSID8029868 Vd NA 3.119 L/kg 1compartment NA NA Human Human +DTXSID8029868 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID8029868 TK.Half.Life NA 109800 hours 1compartment NA NA Human Human +DTXSID8029868 Css NA 3442 mg/L 3compartmentss NA 50% Human Human +DTXSID8029868 Css NA 8781 mg/L 3compartmentss NA 95% Human Human +DTXSID8029868 Css NA 2402 mg/L PBTK NA 50% Human Human +DTXSID8029868 Css NA 5803 mg/L PBTK NA 95% Human Human DTXSID8029868 Clint 86.04 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8029868 Fup 0.044 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID8029868 Vd NA 9.122 L/kg 1compartment NA NA Rat Rat -DTXSID8029868 Days.Css NA 8 Days PBTK NA NA Rat Rat -DTXSID8029868 TK.Half.Life NA 13.58 hours 1compartment NA NA Rat Rat -DTXSID8029868 Css NA 0.2482 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8029868 Css NA 1.049 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8029868 Css NA 0.3309 mg/L PBTK NA 50% Rat Rat -DTXSID8029868 Css NA 1.409 mg/L PBTK NA 95% Rat Rat -DTXSID8030138 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8029868 Vd NA 2.345 L/kg 1compartment NA NA Rat Rat +DTXSID8029868 Days.Css NA 1 Days PBTK NA NA Rat Rat +DTXSID8029868 TK.Half.Life NA 3.786 hours 1compartment NA NA Rat Rat +DTXSID8029868 Css NA 0.03743 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8029868 Css NA 0.2424 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8029868 Css NA 0.02546 mg/L PBTK NA 50% Rat Rat +DTXSID8029868 Css NA 0.16 mg/L PBTK NA 95% Rat Rat +DTXSID8030138 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8030138 Fup 0.93 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID8030138 Vd NA 0.8496 L/kg 1compartment NA NA Human Human DTXSID8030138 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8030138 TK.Half.Life NA 5.929 hours 1compartment NA NA Human Human -DTXSID8030138 Css NA 1.08 mg/L 3compartmentss NA 50% Human Human -DTXSID8030138 Css NA 3.523 mg/L 3compartmentss NA 95% Human Human -DTXSID8030138 Css NA 0.7275 mg/L PBTK NA 50% Human Human -DTXSID8030138 Css NA 2.21 mg/L PBTK NA 95% Human Human -DTXSID8030138 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8030138 Css NA 0.9012 mg/L 3compartmentss NA 50% Human Human +DTXSID8030138 Css NA 2.844 mg/L 3compartmentss NA 95% Human Human +DTXSID8030138 Css NA 0.618 mg/L PBTK NA 50% Human Human +DTXSID8030138 Css NA 1.95 mg/L PBTK NA 95% Human Human +DTXSID8030138 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8030138 Fup 0.93 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID8030138 Vd NA 0.8712 L/kg 1compartment NA NA Rat Human DTXSID8030138 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8030138 TK.Half.Life NA 2.067 hours 1compartment NA NA Rat Human -DTXSID8030138 Css NA 0.2852 mg/L 3compartmentss NA 50% Rat Human -DTXSID8030138 Css NA 0.8471 mg/L 3compartmentss NA 95% Rat Human -DTXSID8030138 Css NA 0.1832 mg/L PBTK NA 50% Rat Human -DTXSID8030138 Css NA 0.4898 mg/L PBTK NA 95% Rat Human -DTXSID8030423 Clint NA 29.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8030423 Fup NA 0.022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8030423 Vd NA 2.949 L/kg 1compartment NA NA Human Human -DTXSID8030423 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8030423 TK.Half.Life NA 39.7 hours 1compartment NA NA Human Human -DTXSID8030423 Css NA 1.71 mg/L 3compartmentss NA 50% Human Human -DTXSID8030423 Css NA 11.27 mg/L 3compartmentss NA 95% Human Human -DTXSID8030423 Css NA 1.171 mg/L PBTK NA 50% Human Human -DTXSID8030423 Css NA 7.381 mg/L PBTK NA 95% Human Human -DTXSID8030423 Clint NA 29.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8030423 Fup NA 0.022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8030423 Vd NA 2.208 L/kg 1compartment NA NA Rat Human -DTXSID8030423 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8030423 TK.Half.Life NA 6.829 hours 1compartment NA NA Rat Human -DTXSID8030423 Css NA 0.955 mg/L 3compartmentss NA 50% Rat Human -DTXSID8030423 Css NA 5.173 mg/L 3compartmentss NA 95% Rat Human -DTXSID8030423 Css NA 0.624 mg/L PBTK NA 50% Rat Human -DTXSID8030423 Css NA 3.332 mg/L PBTK NA 95% Rat Human -DTXSID8030760 Clint NA 106 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8030138 Css NA 0.01534 mg/L 3compartmentss NA 50% Rat Human +DTXSID8030138 Css NA 0.07237 mg/L 3compartmentss NA 95% Rat Human +DTXSID8030138 Css NA 0.01061 mg/L PBTK NA 50% Rat Human +DTXSID8030138 Css NA 0.05102 mg/L PBTK NA 95% Rat Human +DTXSID8030423 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8030423 Fup 0.00516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8030423 Vd NA 2.647 L/kg 1compartment NA NA Human Human +DTXSID8030423 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID8030423 TK.Half.Life NA 63.59 hours 1compartment NA NA Human Human +DTXSID8030423 Css NA 3.366 mg/L 3compartmentss NA 50% Human Human +DTXSID8030423 Css NA 24.16 mg/L 3compartmentss NA 95% Human Human +DTXSID8030423 Css NA 2.226 mg/L PBTK NA 50% Human Human +DTXSID8030423 Css NA 15.19 mg/L PBTK NA 95% Human Human +DTXSID8030423 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8030423 Fup 0.00516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8030423 Vd NA 1.973 L/kg 1compartment NA NA Rat Human +DTXSID8030423 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID8030423 TK.Half.Life NA 13.93 hours 1compartment NA NA Rat Human +DTXSID8030423 Css NA 0.4373 mg/L 3compartmentss NA 50% Rat Human +DTXSID8030423 Css NA 2.723 mg/L 3compartmentss NA 95% Rat Human +DTXSID8030423 Css NA 0.2862 mg/L PBTK NA 50% Rat Human +DTXSID8030423 Css NA 1.699 mg/L PBTK NA 95% Rat Human +DTXSID8030760 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8030760 Fup 0.88 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8030760 Vd NA 3.188 L/kg 1compartment NA NA Human Human -DTXSID8030760 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8030760 TK.Half.Life NA 6.342 hours 1compartment NA NA Human Human -DTXSID8030760 Css NA 0.1466 mg/L 3compartmentss NA 50% Human Human -DTXSID8030760 Css NA 0.9326 mg/L 3compartmentss NA 95% Human Human -DTXSID8030760 Css NA 0.1058 mg/L PBTK NA 50% Human Human -DTXSID8030760 Css NA 0.6504 mg/L PBTK NA 95% Human Human -DTXSID8030760 Clint NA 106 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8030760 Days.Css NA 362 Days PBTK NA NA Human Human +DTXSID8030760 TK.Half.Life NA 1405 hours 1compartment NA NA Human Human +DTXSID8030760 Css NA 38.42 mg/L 3compartmentss NA 50% Human Human +DTXSID8030760 Css NA 111.3 mg/L 3compartmentss NA 95% Human Human +DTXSID8030760 Css NA 27.96 mg/L PBTK NA 50% Human Human +DTXSID8030760 Css NA 74.64 mg/L PBTK NA 95% Human Human +DTXSID8030760 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8030760 Fup 0.88 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8030760 Vd NA 2.418 L/kg 1compartment NA NA Rat Human -DTXSID8030760 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8030760 TK.Half.Life NA 1.33 hours 1compartment NA NA Rat Human -DTXSID8030760 Css NA 0.08152 mg/L 3compartmentss NA 50% Rat Human -DTXSID8030760 Css NA 0.4532 mg/L 3compartmentss NA 95% Rat Human -DTXSID8030760 Css NA 0.05696 mg/L PBTK NA 50% Rat Human -DTXSID8030760 Css NA 0.3086 mg/L PBTK NA 95% Rat Human +DTXSID8030760 Days.Css NA 92 Days PBTK NA NA Rat Human +DTXSID8030760 TK.Half.Life NA 91.19 hours 1compartment NA NA Rat Human +DTXSID8030760 Css NA 0.4166 mg/L 3compartmentss NA 50% Rat Human +DTXSID8030760 Css NA 2.441 mg/L 3compartmentss NA 95% Rat Human +DTXSID8030760 Css NA 0.2911 mg/L PBTK NA 50% Rat Human +DTXSID8030760 Css NA 1.674 mg/L PBTK NA 95% Rat Human DTXSID8031077 Clint 297 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8031077 Fup 4.14e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8031077 Vd NA 0.166 L/kg 1compartment NA NA Human Human +DTXSID8031077 Vd NA 0.1678 L/kg 1compartment NA NA Human Human DTXSID8031077 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8031077 TK.Half.Life NA 18.95 hours 1compartment NA NA Human Human -DTXSID8031077 Css NA 6.693 mg/L 3compartmentss NA 50% Human Human -DTXSID8031077 Css NA 62.06 mg/L 3compartmentss NA 95% Human Human -DTXSID8031077 Css NA 3.904 mg/L PBTK NA 50% Human Human -DTXSID8031077 Css NA 36.11 mg/L PBTK NA 95% Human Human +DTXSID8031077 TK.Half.Life NA 18.76 hours 1compartment NA NA Human Human +DTXSID8031077 Css NA 6.386 mg/L 3compartmentss NA 50% Human Human +DTXSID8031077 Css NA 61.81 mg/L 3compartmentss NA 95% Human Human +DTXSID8031077 Css NA 3.735 mg/L PBTK NA 50% Human Human +DTXSID8031077 Css NA 36.09 mg/L PBTK NA 95% Human Human DTXSID8031077 Clint 297 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8031077 Fup 4.14e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8031077 Vd NA 0.1611 L/kg 1compartment NA NA Rat Human +DTXSID8031077 Vd NA 0.162 L/kg 1compartment NA NA Rat Human DTXSID8031077 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8031077 TK.Half.Life NA 12.85 hours 1compartment NA NA Rat Human -DTXSID8031077 Css NA 4.589 mg/L 3compartmentss NA 50% Rat Human -DTXSID8031077 Css NA 28.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID8031077 Css NA 2.479 mg/L PBTK NA 50% Rat Human -DTXSID8031077 Css NA 15.13 mg/L PBTK NA 95% Rat Human -DTXSID8031366 Clint NA 1.374 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8031366 Fup NA 0.3439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8031366 Vd NA 0.3741 L/kg 1compartment NA NA Human Human -DTXSID8031366 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8031366 TK.Half.Life NA 2.27 hours 1compartment NA NA Human Human -DTXSID8031366 Css NA 0.6922 mg/L 3compartmentss NA 50% Human Human -DTXSID8031366 Css NA 3.275 mg/L 3compartmentss NA 95% Human Human -DTXSID8031366 Css NA 0.4756 mg/L PBTK NA 50% Human Human -DTXSID8031366 Css NA 2.044 mg/L PBTK NA 95% Human Human -DTXSID8031366 Clint NA 1.374 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8031366 Fup NA 0.3439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8031366 Vd NA 0.3797 L/kg 1compartment NA NA Rat Human -DTXSID8031366 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8031366 TK.Half.Life NA 1.184 hours 1compartment NA NA Rat Human -DTXSID8031366 Css NA 0.2964 mg/L 3compartmentss NA 50% Rat Human -DTXSID8031366 Css NA 1.128 mg/L 3compartmentss NA 95% Rat Human -DTXSID8031366 Css NA 0.1942 mg/L PBTK NA 50% Rat Human -DTXSID8031366 Css NA 0.6534 mg/L PBTK NA 95% Rat Human -DTXSID8031603 Clint NA 6.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8031603 Fup NA 0.1544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8031603 Vd NA 1.255 L/kg 1compartment NA NA Human Human +DTXSID8031077 TK.Half.Life NA 12.65 hours 1compartment NA NA Rat Human +DTXSID8031077 Css NA 1.009 mg/L 3compartmentss NA 50% Rat Human +DTXSID8031077 Css NA 6.417 mg/L 3compartmentss NA 95% Rat Human +DTXSID8031077 Css NA 0.5646 mg/L PBTK NA 50% Rat Human +DTXSID8031077 Css NA 3.59 mg/L PBTK NA 95% Rat Human +DTXSID8031497 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8031497 Fup 0.767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8031497 Vd NA 1.234 L/kg 1compartment NA NA Human Human +DTXSID8031497 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8031497 TK.Half.Life NA 11.14 hours 1compartment NA NA Human Human +DTXSID8031497 Css NA 0.8288 mg/L 3compartmentss NA 50% Human Human +DTXSID8031497 Css NA 5.499 mg/L 3compartmentss NA 95% Human Human +DTXSID8031497 Css NA 0.7389 mg/L PBTK NA 50% Human Human +DTXSID8031497 Css NA 3.707 mg/L PBTK NA 95% Human Human +DTXSID8031497 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8031497 Fup 0.767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8031497 Vd NA 1.141 L/kg 1compartment NA NA Rat Human +DTXSID8031497 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8031497 TK.Half.Life NA 3.336 hours 1compartment NA NA Rat Human +DTXSID8031497 Css NA 0.01553 mg/L 3compartmentss NA 50% Rat Human +DTXSID8031497 Css NA 0.1218 mg/L 3compartmentss NA 95% Rat Human +DTXSID8031497 Css NA 0.01346 mg/L PBTK NA 50% Rat Human +DTXSID8031497 Css NA 0.08096 mg/L PBTK NA 95% Rat Human +DTXSID8031603 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8031603 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8031603 Vd NA 1.316 L/kg 1compartment NA NA Human Human DTXSID8031603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8031603 TK.Half.Life NA 6.048 hours 1compartment NA NA Human Human -DTXSID8031603 Css NA 0.5786 mg/L 3compartmentss NA 50% Human Human -DTXSID8031603 Css NA 3.779 mg/L 3compartmentss NA 95% Human Human -DTXSID8031603 Css NA 0.3934 mg/L PBTK NA 50% Human Human -DTXSID8031603 Css NA 2.395 mg/L PBTK NA 95% Human Human -DTXSID8031603 Clint NA 6.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8031603 Fup NA 0.1544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8031603 Vd NA 0.9793 L/kg 1compartment NA NA Rat Human +DTXSID8031603 TK.Half.Life NA 2.54 hours 1compartment NA NA Human Human +DTXSID8031603 Css NA 0.1432 mg/L 3compartmentss NA 50% Human Human +DTXSID8031603 Css NA 0.9839 mg/L 3compartmentss NA 95% Human Human +DTXSID8031603 Css NA 0.1007 mg/L PBTK NA 50% Human Human +DTXSID8031603 Css NA 0.6561 mg/L PBTK NA 95% Human Human +DTXSID8031603 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8031603 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8031603 Vd NA 1.027 L/kg 1compartment NA NA Rat Human DTXSID8031603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8031603 TK.Half.Life NA 2.482 hours 1compartment NA NA Rat Human -DTXSID8031603 Css NA 0.303 mg/L 3compartmentss NA 50% Rat Human -DTXSID8031603 Css NA 1.459 mg/L 3compartmentss NA 95% Rat Human -DTXSID8031603 Css NA 0.1979 mg/L PBTK NA 50% Rat Human -DTXSID8031603 Css NA 0.864 mg/L PBTK NA 95% Rat Human -DTXSID8031863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8031863 Fup 0.000992 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8031863 Vd NA 0.1669 L/kg 1compartment NA NA Human Human -DTXSID8031863 Days.Css NA 330 Days PBTK NA NA Human Human -DTXSID8031863 TK.Half.Life NA 1088 hours 1compartment NA NA Human Human -DTXSID8031863 Css NA 1128 mg/L 3compartmentss NA 50% Human Human -DTXSID8031863 Css NA 6409 mg/L 3compartmentss NA 95% Human Human -DTXSID8031863 Css NA 663.1 mg/L PBTK NA 50% Human Human -DTXSID8031863 Css NA 3705 mg/L PBTK NA 95% Human Human -DTXSID8031863 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8031863 Fup 0.000992 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8031863 Vd NA 0.1643 L/kg 1compartment NA NA Rat Human -DTXSID8031863 Days.Css NA 102 Days PBTK NA NA Rat Human -DTXSID8031863 TK.Half.Life NA 365.2 hours 1compartment NA NA Rat Human -DTXSID8031863 Css NA 323.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID8031863 Css NA 1706 mg/L 3compartmentss NA 95% Rat Human -DTXSID8031863 Css NA 174.9 mg/L PBTK NA 50% Rat Human -DTXSID8031863 Css NA 921.7 mg/L PBTK NA 95% Rat Human -DTXSID8031865 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID8031865 Fup 0.004779 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID8031865 Vd NA 0.1849 L/kg 1compartment NA NA Human Human -DTXSID8031865 Days.Css NA 63 Days PBTK NA NA Human Human -DTXSID8031865 TK.Half.Life NA 250.3 hours 1compartment NA NA Human Human -DTXSID8031865 Css NA 214 mg/L 3compartmentss NA 50% Human Human -DTXSID8031865 Css NA 1359 mg/L 3compartmentss NA 95% Human Human -DTXSID8031865 Css NA 137.9 mg/L PBTK NA 50% Human Human -DTXSID8031865 Css NA 814 mg/L PBTK NA 95% Human Human -DTXSID8031865 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID8031865 Fup 0.002929 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID8031865 Vd NA 0.1722 L/kg 1compartment NA NA Rat Rat -DTXSID8031865 Days.Css NA 30 Days PBTK NA NA Rat Rat -DTXSID8031865 TK.Half.Life NA 129.6 hours 1compartment NA NA Rat Rat -DTXSID8031865 Css NA 100.2 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8031865 Css NA 345 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8031865 Css NA 60.68 mg/L PBTK NA 50% Rat Rat -DTXSID8031865 Css NA 193.4 mg/L PBTK NA 95% Rat Rat +DTXSID8031603 TK.Half.Life NA 1.014 hours 1compartment NA NA Rat Human +DTXSID8031603 Css NA 0.01841 mg/L 3compartmentss NA 50% Rat Human +DTXSID8031603 Css NA 0.09657 mg/L 3compartmentss NA 95% Rat Human +DTXSID8031603 Css NA 0.01277 mg/L PBTK NA 50% Rat Human +DTXSID8031603 Css NA 0.06306 mg/L PBTK NA 95% Rat Human +DTXSID8032330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032330 Fup 0.00224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032330 Vd NA 3.003 L/kg 1compartment NA NA Human Human +DTXSID8032330 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID8032330 TK.Half.Life NA 95.04 hours 1compartment NA NA Human Human +DTXSID8032330 Css NA 3.763 mg/L 3compartmentss NA 50% Human Human +DTXSID8032330 Css NA 23.27 mg/L 3compartmentss NA 95% Human Human +DTXSID8032330 Css NA 2.584 mg/L PBTK NA 50% Human Human +DTXSID8032330 Css NA 15.58 mg/L PBTK NA 95% Human Human +DTXSID8032330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032330 Fup 0.00224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032330 Vd NA 2.246 L/kg 1compartment NA NA Rat Human +DTXSID8032330 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID8032330 TK.Half.Life NA 14.76 hours 1compartment NA NA Rat Human +DTXSID8032330 Css NA 0.4955 mg/L 3compartmentss NA 50% Rat Human +DTXSID8032330 Css NA 2.399 mg/L 3compartmentss NA 95% Rat Human +DTXSID8032330 Css NA 0.3344 mg/L PBTK NA 50% Rat Human +DTXSID8032330 Css NA 1.647 mg/L PBTK NA 95% Rat Human DTXSID8032386 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID8032386 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8032386 Vd NA 3.062 L/kg 1compartment NA NA Human Human +DTXSID8032386 Fup 0.00814 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032386 Vd NA 2.897 L/kg 1compartment NA NA Human Human DTXSID8032386 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8032386 TK.Half.Life NA 19370 hours 1compartment NA NA Human Human -DTXSID8032386 Css NA 749.7 mg/L 3compartmentss NA 50% Human Human -DTXSID8032386 Css NA 2094 mg/L 3compartmentss NA 95% Human Human -DTXSID8032386 Css NA 515.2 mg/L PBTK NA 50% Human Human -DTXSID8032386 Css NA 1358 mg/L PBTK NA 95% Human Human +DTXSID8032386 TK.Half.Life NA 19920 hours 1compartment NA NA Human Human +DTXSID8032386 Css NA 836.6 mg/L 3compartmentss NA 50% Human Human +DTXSID8032386 Css NA 2527 mg/L 3compartmentss NA 95% Human Human +DTXSID8032386 Css NA 571.2 mg/L PBTK NA 50% Human Human +DTXSID8032386 Css NA 1607 mg/L PBTK NA 95% Human Human DTXSID8032386 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID8032386 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8032386 Vd NA 2.295 L/kg 1compartment NA NA Rat Human -DTXSID8032386 Days.Css NA 1365 Days PBTK NA NA Rat Human -DTXSID8032386 TK.Half.Life NA 1325 hours 1compartment NA NA Rat Human -DTXSID8032386 Css NA 201.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID8032386 Css NA 457.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID8032386 Css NA 133.5 mg/L PBTK NA 50% Rat Human -DTXSID8032386 Css NA 274 mg/L PBTK NA 95% Rat Human +DTXSID8032386 Fup 0.00814 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032386 Vd NA 2.166 L/kg 1compartment NA NA Rat Human +DTXSID8032386 Days.Css NA 1394 Days PBTK NA NA Rat Human +DTXSID8032386 TK.Half.Life NA 1657 hours 1compartment NA NA Rat Human +DTXSID8032386 Css NA 52.56 mg/L 3compartmentss NA 50% Rat Human +DTXSID8032386 Css NA 128.6 mg/L 3compartmentss NA 95% Rat Human +DTXSID8032386 Css NA 35.24 mg/L PBTK NA 50% Rat Human +DTXSID8032386 Css NA 78.36 mg/L PBTK NA 95% Rat Human DTXSID8032417 Clint 158 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8032417 Fup 0.0105 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8032417 Vd NA 2.015 L/kg 1compartment NA NA Human Human DTXSID8032417 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8032417 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human -DTXSID8032417 Css NA 0.246 mg/L 3compartmentss NA 50% Human Human +DTXSID8032417 Css NA 0.2352 mg/L 3compartmentss NA 50% Human Human DTXSID8032417 Css NA 1.715 mg/L 3compartmentss NA 95% Human Human -DTXSID8032417 Css NA 0.1608 mg/L PBTK NA 50% Human Human -DTXSID8032417 Css NA 1.084 mg/L PBTK NA 95% Human Human +DTXSID8032417 Css NA 0.1542 mg/L PBTK NA 50% Human Human +DTXSID8032417 Css NA 1.103 mg/L PBTK NA 95% Human Human DTXSID8032417 Clint 158 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8032417 Fup 0.0105 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8032417 Vd NA 1.493 L/kg 1compartment NA NA Rat Human DTXSID8032417 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8032417 TK.Half.Life NA 1.869 hours 1compartment NA NA Rat Human -DTXSID8032417 Css NA 0.1397 mg/L 3compartmentss NA 50% Rat Human -DTXSID8032417 Css NA 0.8338 mg/L 3compartmentss NA 95% Rat Human -DTXSID8032417 Css NA 0.08633 mg/L PBTK NA 50% Rat Human -DTXSID8032417 Css NA 0.5103 mg/L PBTK NA 95% Rat Human +DTXSID8032417 Css NA 0.03098 mg/L 3compartmentss NA 50% Rat Human +DTXSID8032417 Css NA 0.1916 mg/L 3compartmentss NA 95% Rat Human +DTXSID8032417 Css NA 0.01997 mg/L PBTK NA 50% Rat Human +DTXSID8032417 Css NA 0.1202 mg/L PBTK NA 95% Rat Human +DTXSID8032463 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032463 Fup 0.0651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032463 Vd NA 0.4151 L/kg 1compartment NA NA Human Human +DTXSID8032463 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8032463 TK.Half.Life NA 1.457 hours 1compartment NA NA Human Human +DTXSID8032463 Css NA 0.3768 mg/L 3compartmentss NA 50% Human Human +DTXSID8032463 Css NA 2.898 mg/L 3compartmentss NA 95% Human Human +DTXSID8032463 Css NA 0.2421 mg/L PBTK NA 50% Human Human +DTXSID8032463 Css NA 1.79 mg/L PBTK NA 95% Human Human +DTXSID8032463 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032463 Fup 0.0651 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032463 Vd NA 0.4051 L/kg 1compartment NA NA Rat Human +DTXSID8032463 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8032463 TK.Half.Life NA 0.8802 hours 1compartment NA NA Rat Human +DTXSID8032463 Css NA 0.01831 mg/L 3compartmentss NA 50% Rat Human +DTXSID8032463 Css NA 0.1508 mg/L 3compartmentss NA 95% Rat Human +DTXSID8032463 Css NA 0.01131 mg/L PBTK NA 50% Rat Human +DTXSID8032463 Css NA 0.08955 mg/L PBTK NA 95% Rat Human DTXSID8032544 Clint 592 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8032544 Fup 0.865 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8032544 Vd NA 1.845 L/kg 1compartment NA NA Human Human DTXSID8032544 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8032544 TK.Half.Life NA 0.8392 hours 1compartment NA NA Human Human -DTXSID8032544 Css NA 0.0007219 mg/L 3compartmentss NA 50% Human Human -DTXSID8032544 Css NA 0.005088 mg/L 3compartmentss NA 95% Human Human -DTXSID8032544 Css NA 0.0008194 mg/L PBTK NA 50% Human Human -DTXSID8032544 Css NA 0.00501 mg/L PBTK NA 95% Human Human +DTXSID8032544 Css NA 0.0002376 mg/L 3compartmentss NA 50% Human Human +DTXSID8032544 Css NA 0.003894 mg/L 3compartmentss NA 95% Human Human +DTXSID8032544 Css NA 0.0002677 mg/L PBTK NA 50% Human Human +DTXSID8032544 Css NA 0.003892 mg/L PBTK NA 95% Human Human DTXSID8032544 Clint 592 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8032544 Fup 0.865 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8032544 Vd NA 1.629 L/kg 1compartment NA NA Rat Human DTXSID8032544 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8032544 TK.Half.Life NA 0.319 hours 1compartment NA NA Rat Human -DTXSID8032544 Css NA 0.0003728 mg/L 3compartmentss NA 50% Rat Human -DTXSID8032544 Css NA 0.002265 mg/L 3compartmentss NA 95% Rat Human -DTXSID8032544 Css NA 0.0004278 mg/L PBTK NA 50% Rat Human -DTXSID8032544 Css NA 0.002289 mg/L PBTK NA 95% Rat Human +DTXSID8032544 Css NA 3.238e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID8032544 Css NA 0.0004183 mg/L 3compartmentss NA 95% Rat Human +DTXSID8032544 Css NA 3.979e-05 mg/L PBTK NA 50% Rat Human +DTXSID8032544 Css NA 0.0004568 mg/L PBTK NA 95% Rat Human DTXSID8032548 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8032548 Fup 0.0188 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8032548 Vd NA 1.135 L/kg 1compartment NA NA Human Human DTXSID8032548 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8032548 TK.Half.Life NA 10.52 hours 1compartment NA NA Human Human -DTXSID8032548 Css NA 1.046 mg/L 3compartmentss NA 50% Human Human -DTXSID8032548 Css NA 7.215 mg/L 3compartmentss NA 95% Human Human -DTXSID8032548 Css NA 0.6808 mg/L PBTK NA 50% Human Human -DTXSID8032548 Css NA 4.487 mg/L PBTK NA 95% Human Human +DTXSID8032548 Css NA 1.026 mg/L 3compartmentss NA 50% Human Human +DTXSID8032548 Css NA 7.519 mg/L 3compartmentss NA 95% Human Human +DTXSID8032548 Css NA 0.6599 mg/L PBTK NA 50% Human Human +DTXSID8032548 Css NA 4.838 mg/L PBTK NA 95% Human Human DTXSID8032548 Clint 3.886 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8032548 Fup 0.293 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8032548 Vd NA 2.121 L/kg 1compartment NA NA Rat Rat DTXSID8032548 Days.Css NA 1 Days PBTK NA NA Rat Rat DTXSID8032548 TK.Half.Life NA 6.156 hours 1compartment NA NA Rat Rat -DTXSID8032548 Css NA 0.7795 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8032548 Css NA 2.423 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8032548 Css NA 0.435 mg/L PBTK NA 50% Rat Rat -DTXSID8032548 Css NA 1.346 mg/L PBTK NA 95% Rat Rat -DTXSID8032623 Clint NA 1.122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8032623 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8032623 Vd NA 0.2421 L/kg 1compartment NA NA Human Human -DTXSID8032623 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8032623 TK.Half.Life NA 18.07 hours 1compartment NA NA Human Human -DTXSID8032623 Css NA 12.86 mg/L 3compartmentss NA 50% Human Human -DTXSID8032623 Css NA 87.56 mg/L 3compartmentss NA 95% Human Human -DTXSID8032623 Css NA 7.719 mg/L PBTK NA 50% Human Human -DTXSID8032623 Css NA 50.26 mg/L PBTK NA 95% Human Human -DTXSID8032623 Clint NA 1.122 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8032623 Fup NA 0.0305 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8032623 Vd NA 0.2375 L/kg 1compartment NA NA Rat Human +DTXSID8032548 Css NA 0.1512 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8032548 Css NA 0.4812 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8032548 Css NA 0.1008 mg/L PBTK NA 50% Rat Rat +DTXSID8032548 Css NA 0.3206 mg/L PBTK NA 95% Rat Rat +DTXSID8032623 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032623 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032623 Vd NA 0.4967 L/kg 1compartment NA NA Human Human +DTXSID8032623 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8032623 TK.Half.Life NA 10.51 hours 1compartment NA NA Human Human +DTXSID8032623 Css NA 2.312 mg/L 3compartmentss NA 50% Human Human +DTXSID8032623 Css NA 9.4 mg/L 3compartmentss NA 95% Human Human +DTXSID8032623 Css NA 1.69 mg/L PBTK NA 50% Human Human +DTXSID8032623 Css NA 5.977 mg/L PBTK NA 95% Human Human +DTXSID8032623 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032623 Fup 0.306 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032623 Vd NA 0.4946 L/kg 1compartment NA NA Rat Human DTXSID8032623 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8032623 TK.Half.Life NA 9.05 hours 1compartment NA NA Rat Human -DTXSID8032623 Css NA 5.651 mg/L 3compartmentss NA 50% Rat Human -DTXSID8032623 Css NA 31.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID8032623 Css NA 3.156 mg/L PBTK NA 50% Rat Human -DTXSID8032623 Css NA 17.33 mg/L PBTK NA 95% Rat Human -DTXSID8032627 Clint NA 95.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8032627 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8032627 Vd NA 3.082 L/kg 1compartment NA NA Human Human -DTXSID8032627 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8032627 TK.Half.Life NA 20.42 hours 1compartment NA NA Human Human -DTXSID8032627 Css NA 0.733 mg/L 3compartmentss NA 50% Human Human -DTXSID8032627 Css NA 4.752 mg/L 3compartmentss NA 95% Human Human -DTXSID8032627 Css NA 0.5094 mg/L PBTK NA 50% Human Human -DTXSID8032627 Css NA 3.188 mg/L PBTK NA 95% Human Human -DTXSID8032627 Clint NA 95.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8032627 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8032627 Vd NA 2.308 L/kg 1compartment NA NA Rat Human -DTXSID8032627 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8032627 TK.Half.Life NA 3.271 hours 1compartment NA NA Rat Human -DTXSID8032627 Css NA 0.4146 mg/L 3compartmentss NA 50% Rat Human -DTXSID8032627 Css NA 2.183 mg/L 3compartmentss NA 95% Rat Human -DTXSID8032627 Css NA 0.2734 mg/L PBTK NA 50% Rat Human -DTXSID8032627 Css NA 1.375 mg/L PBTK NA 95% Rat Human -DTXSID8032671 Clint NA 97.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8032671 Fup NA 0.1712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8032671 Vd NA 0.76 L/kg 1compartment NA NA Human Human +DTXSID8032623 TK.Half.Life NA 3.564 hours 1compartment NA NA Rat Human +DTXSID8032623 Css NA 0.1493 mg/L 3compartmentss NA 50% Rat Human +DTXSID8032623 Css NA 0.5071 mg/L 3compartmentss NA 95% Rat Human +DTXSID8032623 Css NA 0.1074 mg/L PBTK NA 50% Rat Human +DTXSID8032623 Css NA 0.3116 mg/L PBTK NA 95% Rat Human +DTXSID8032627 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032627 Fup 0.0265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032627 Vd NA 3.107 L/kg 1compartment NA NA Human Human +DTXSID8032627 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID8032627 TK.Half.Life NA 81.36 hours 1compartment NA NA Human Human +DTXSID8032627 Css NA 3.134 mg/L 3compartmentss NA 50% Human Human +DTXSID8032627 Css NA 19.65 mg/L 3compartmentss NA 95% Human Human +DTXSID8032627 Css NA 2.163 mg/L PBTK NA 50% Human Human +DTXSID8032627 Css NA 13.42 mg/L PBTK NA 95% Human Human +DTXSID8032627 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032627 Fup 0.0265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032627 Vd NA 2.328 L/kg 1compartment NA NA Rat Human +DTXSID8032627 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID8032627 TK.Half.Life NA 11.2 hours 1compartment NA NA Rat Human +DTXSID8032627 Css NA 0.4027 mg/L 3compartmentss NA 50% Rat Human +DTXSID8032627 Css NA 2.242 mg/L 3compartmentss NA 95% Rat Human +DTXSID8032627 Css NA 0.2774 mg/L PBTK NA 50% Rat Human +DTXSID8032627 Css NA 1.506 mg/L PBTK NA 95% Rat Human +DTXSID8032671 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032671 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032671 Vd NA 1.532 L/kg 1compartment NA NA Human Human DTXSID8032671 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8032671 TK.Half.Life NA 0.7971 hours 1compartment NA NA Human Human -DTXSID8032671 Css NA 0.03044 mg/L 3compartmentss NA 50% Human Human -DTXSID8032671 Css NA 0.23 mg/L 3compartmentss NA 95% Human Human -DTXSID8032671 Css NA 0.0208 mg/L PBTK NA 50% Human Human -DTXSID8032671 Css NA 0.1483 mg/L PBTK NA 95% Human Human -DTXSID8032671 Clint NA 97.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8032671 Fup NA 0.1712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8032671 Vd NA 0.6462 L/kg 1compartment NA NA Rat Human +DTXSID8032671 TK.Half.Life NA 2.404 hours 1compartment NA NA Human Human +DTXSID8032671 Css NA 0.1132 mg/L 3compartmentss NA 50% Human Human +DTXSID8032671 Css NA 0.9864 mg/L 3compartmentss NA 95% Human Human +DTXSID8032671 Css NA 0.09791 mg/L PBTK NA 50% Human Human +DTXSID8032671 Css NA 0.7009 mg/L PBTK NA 95% Human Human +DTXSID8032671 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032671 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032671 Vd NA 1.319 L/kg 1compartment NA NA Rat Human DTXSID8032671 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8032671 TK.Half.Life NA 0.3282 hours 1compartment NA NA Rat Human -DTXSID8032671 Css NA 0.01705 mg/L 3compartmentss NA 50% Rat Human -DTXSID8032671 Css NA 0.09979 mg/L 3compartmentss NA 95% Rat Human -DTXSID8032671 Css NA 0.01102 mg/L PBTK NA 50% Rat Human -DTXSID8032671 Css NA 0.06058 mg/L PBTK NA 95% Rat Human +DTXSID8032671 TK.Half.Life NA 1.032 hours 1compartment NA NA Rat Human +DTXSID8032671 Css NA 0.01254 mg/L 3compartmentss NA 50% Rat Human +DTXSID8032671 Css NA 0.09548 mg/L 3compartmentss NA 95% Rat Human +DTXSID8032671 Css NA 0.01111 mg/L PBTK NA 50% Rat Human +DTXSID8032671 Css NA 0.06368 mg/L PBTK NA 95% Rat Human DTXSID8032673 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8032673 Fup 0.0334 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8032673 Vd NA 0.2712 L/kg 1compartment NA NA Human Human -DTXSID8032673 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID8032673 TK.Half.Life NA 52.55 hours 1compartment NA NA Human Human -DTXSID8032673 Css NA 19.96 mg/L 3compartmentss NA 50% Human Human -DTXSID8032673 Css NA 102 mg/L 3compartmentss NA 95% Human Human -DTXSID8032673 Css NA 14.91 mg/L PBTK NA 50% Human Human -DTXSID8032673 Css NA 64.4 mg/L PBTK NA 95% Human Human +DTXSID8032673 Vd NA 0.2086 L/kg 1compartment NA NA Human Human +DTXSID8032673 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID8032673 TK.Half.Life NA 40.42 hours 1compartment NA NA Human Human +DTXSID8032673 Css NA 19.91 mg/L 3compartmentss NA 50% Human Human +DTXSID8032673 Css NA 84.37 mg/L 3compartmentss NA 95% Human Human +DTXSID8032673 Css NA 14.46 mg/L PBTK NA 50% Human Human +DTXSID8032673 Css NA 61.28 mg/L PBTK NA 95% Human Human DTXSID8032673 Clint 1.949 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8032673 Fup 0.009272 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID8032673 Vd NA 0.1915 L/kg 1compartment NA NA Rat Rat +DTXSID8032673 Vd 0.35 0.1727 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID8032673 Days.Css NA 2 Days PBTK NA NA Rat Rat -DTXSID8032673 TK.Half.Life NA 17.77 hours 1compartment NA NA Rat Rat -DTXSID8032673 Css NA 11.28 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8032673 Css NA 82.55 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8032673 Css NA 7.634 mg/L PBTK NA 50% Rat Rat -DTXSID8032673 Css NA 46.62 mg/L PBTK NA 95% Rat Rat -DTXSID8032675 Clint NA 80.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8032675 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8032675 Vd NA 3.072 L/kg 1compartment NA NA Human Human -DTXSID8032675 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8032675 TK.Half.Life NA 23.67 hours 1compartment NA NA Human Human -DTXSID8032675 Css NA 0.882 mg/L 3compartmentss NA 50% Human Human -DTXSID8032675 Css NA 5.567 mg/L 3compartmentss NA 95% Human Human -DTXSID8032675 Css NA 0.6061 mg/L PBTK NA 50% Human Human -DTXSID8032675 Css NA 3.776 mg/L PBTK NA 95% Human Human -DTXSID8032675 Clint NA 80.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8032675 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8032675 Vd NA 2.301 L/kg 1compartment NA NA Rat Human -DTXSID8032675 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8032675 TK.Half.Life NA 3.751 hours 1compartment NA NA Rat Human -DTXSID8032675 Css NA 0.498 mg/L 3compartmentss NA 50% Rat Human -DTXSID8032675 Css NA 2.593 mg/L 3compartmentss NA 95% Rat Human -DTXSID8032675 Css NA 0.3286 mg/L PBTK NA 50% Rat Human -DTXSID8032675 Css NA 1.635 mg/L PBTK NA 95% Rat Human -DTXSID8033433 Clint NA 2.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033433 Fup NA 0.1181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033433 Vd NA 1.257 L/kg 1compartment NA NA Human Human -DTXSID8033433 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8033433 TK.Half.Life NA 16.25 hours 1compartment NA NA Human Human -DTXSID8033433 Css NA 1.85 mg/L 3compartmentss NA 50% Human Human -DTXSID8033433 Css NA 10.6 mg/L 3compartmentss NA 95% Human Human -DTXSID8033433 Css NA 1.236 mg/L PBTK NA 50% Human Human -DTXSID8033433 Css NA 6.525 mg/L PBTK NA 95% Human Human -DTXSID8033433 Clint NA 2.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033433 Fup NA 0.1181 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033433 Vd NA 0.9788 L/kg 1compartment NA NA Rat Human +DTXSID8032673 TK.Half.Life 0.15 15.67 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID8032673 Css 0.026 2.336 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID8032673 Css 0.026 13.73 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID8032673 Css 0.026 1.756 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID8032673 Css 0.026 10.33 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID8032675 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032675 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8032675 Vd NA 3.058 L/kg 1compartment NA NA Human Human +DTXSID8032675 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID8032675 TK.Half.Life NA 80.9 hours 1compartment NA NA Human Human +DTXSID8032675 Css NA 3.214 mg/L 3compartmentss NA 50% Human Human +DTXSID8032675 Css NA 21.12 mg/L 3compartmentss NA 95% Human Human +DTXSID8032675 Css NA 2.221 mg/L PBTK NA 50% Human Human +DTXSID8032675 Css NA 14.41 mg/L PBTK NA 95% Human Human +DTXSID8032675 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032675 Fup 0.0111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8032675 Vd NA 2.289 L/kg 1compartment NA NA Rat Human +DTXSID8032675 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID8032675 TK.Half.Life NA 11.86 hours 1compartment NA NA Rat Human +DTXSID8032675 Css NA 0.4184 mg/L 3compartmentss NA 50% Rat Human +DTXSID8032675 Css NA 2.374 mg/L 3compartmentss NA 95% Rat Human +DTXSID8032675 Css NA 0.2848 mg/L PBTK NA 50% Rat Human +DTXSID8032675 Css NA 1.58 mg/L PBTK NA 95% Rat Human +DTXSID80332078 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80332078 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80332078 Vd NA 0.3948 L/kg 1compartment NA NA Human Human +DTXSID80332078 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80332078 TK.Half.Life NA 0.5204 hours 1compartment NA NA Human Human +DTXSID80332078 Css NA 0.01623 mg/L 3compartmentss NA 50% Human Human +DTXSID80332078 Css NA 0.167 mg/L 3compartmentss NA 95% Human Human +DTXSID80332078 Css NA 0.01105 mg/L PBTK NA 50% Human Human +DTXSID80332078 Css NA 0.1074 mg/L PBTK NA 95% Human Human +DTXSID80332078 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80332078 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80332078 Vd NA 0.4127 L/kg 1compartment NA NA Rat Human +DTXSID80332078 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80332078 TK.Half.Life NA 0.2862 hours 1compartment NA NA Rat Human +DTXSID80332078 Css NA 0.0001175 mg/L 3compartmentss NA 50% Rat Human +DTXSID80332078 Css NA 0.001043 mg/L 3compartmentss NA 95% Rat Human +DTXSID80332078 Css NA 7.64e-05 mg/L PBTK NA 50% Rat Human +DTXSID80332078 Css NA 0.0006385 mg/L PBTK NA 95% Rat Human +DTXSID80332790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80332790 Fup 0.0327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80332790 Vd NA 1.179 L/kg 1compartment NA NA Human Human +DTXSID80332790 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80332790 TK.Half.Life NA 7.226 hours 1compartment NA NA Human Human +DTXSID80332790 Css NA 0.9076 mg/L 3compartmentss NA 50% Human Human +DTXSID80332790 Css NA 8.338 mg/L 3compartmentss NA 95% Human Human +DTXSID80332790 Css NA 0.5663 mg/L PBTK NA 50% Human Human +DTXSID80332790 Css NA 5.029 mg/L PBTK NA 95% Human Human +DTXSID80332790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80332790 Fup 0.0327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80332790 Vd NA 0.8839 L/kg 1compartment NA NA Rat Human +DTXSID80332790 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80332790 TK.Half.Life NA 3.036 hours 1compartment NA NA Rat Human +DTXSID80332790 Css NA 0.1205 mg/L 3compartmentss NA 50% Rat Human +DTXSID80332790 Css NA 0.8489 mg/L 3compartmentss NA 95% Rat Human +DTXSID80332790 Css NA 0.07254 mg/L PBTK NA 50% Rat Human +DTXSID80332790 Css NA 0.4885 mg/L PBTK NA 95% Rat Human +DTXSID80333449 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80333449 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80333449 Vd NA 0.9847 L/kg 1compartment NA NA Human Human +DTXSID80333449 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80333449 TK.Half.Life NA 2.039 hours 1compartment NA NA Human Human +DTXSID80333449 Css NA 0.1859 mg/L 3compartmentss NA 50% Human Human +DTXSID80333449 Css NA 1.484 mg/L 3compartmentss NA 95% Human Human +DTXSID80333449 Css NA 0.1234 mg/L PBTK NA 50% Human Human +DTXSID80333449 Css NA 0.9529 mg/L PBTK NA 95% Human Human +DTXSID80333449 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80333449 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80333449 Vd NA 0.8061 L/kg 1compartment NA NA Rat Human +DTXSID80333449 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80333449 TK.Half.Life NA 0.9163 hours 1compartment NA NA Rat Human +DTXSID80333449 Css NA 0.02401 mg/L 3compartmentss NA 50% Rat Human +DTXSID80333449 Css NA 0.1481 mg/L 3compartmentss NA 95% Rat Human +DTXSID80333449 Css NA 0.01577 mg/L PBTK NA 50% Rat Human +DTXSID80333449 Css NA 0.08985 mg/L PBTK NA 95% Rat Human +DTXSID8033433 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033433 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033433 Vd NA 1.688 L/kg 1compartment NA NA Human Human +DTXSID8033433 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8033433 TK.Half.Life NA 4.126 hours 1compartment NA NA Human Human +DTXSID8033433 Css NA 0.236 mg/L 3compartmentss NA 50% Human Human +DTXSID8033433 Css NA 1.734 mg/L 3compartmentss NA 95% Human Human +DTXSID8033433 Css NA 0.1609 mg/L PBTK NA 50% Human Human +DTXSID8033433 Css NA 1.119 mg/L PBTK NA 95% Human Human +DTXSID8033433 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033433 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033433 Vd NA 1.297 L/kg 1compartment NA NA Rat Human DTXSID8033433 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8033433 TK.Half.Life NA 6.245 hours 1compartment NA NA Rat Human -DTXSID8033433 Css NA 0.8854 mg/L 3compartmentss NA 50% Rat Human -DTXSID8033433 Css NA 3.813 mg/L 3compartmentss NA 95% Rat Human -DTXSID8033433 Css NA 0.5556 mg/L PBTK NA 50% Rat Human -DTXSID8033433 Css NA 2.173 mg/L PBTK NA 95% Rat Human -DTXSID8033512 Clint NA 11.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033512 Fup NA 0.1151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033512 Vd NA 1.167 L/kg 1compartment NA NA Human Human +DTXSID8033433 TK.Half.Life NA 1.525 hours 1compartment NA NA Rat Human +DTXSID8033433 Css NA 0.03032 mg/L 3compartmentss NA 50% Rat Human +DTXSID8033433 Css NA 0.1762 mg/L 3compartmentss NA 95% Rat Human +DTXSID8033433 Css NA 0.02033 mg/L PBTK NA 50% Rat Human +DTXSID8033433 Css NA 0.1116 mg/L PBTK NA 95% Rat Human +DTXSID80334653 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80334653 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80334653 Vd NA 0.7834 L/kg 1compartment NA NA Human Human +DTXSID80334653 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80334653 TK.Half.Life NA 7.566 hours 1compartment NA NA Human Human +DTXSID80334653 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human +DTXSID80334653 Css NA 6.946 mg/L 3compartmentss NA 95% Human Human +DTXSID80334653 Css NA 0.8912 mg/L PBTK NA 50% Human Human +DTXSID80334653 Css NA 4.509 mg/L PBTK NA 95% Human Human +DTXSID80334653 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80334653 Fup 0.675 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80334653 Vd NA 0.7845 L/kg 1compartment NA NA Rat Human +DTXSID80334653 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80334653 TK.Half.Life NA 2.567 hours 1compartment NA NA Rat Human +DTXSID80334653 Css NA 0.06432 mg/L 3compartmentss NA 50% Rat Human +DTXSID80334653 Css NA 0.4148 mg/L 3compartmentss NA 95% Rat Human +DTXSID80334653 Css NA 0.05301 mg/L PBTK NA 50% Rat Human +DTXSID80334653 Css NA 0.255 mg/L PBTK NA 95% Rat Human +DTXSID8033512 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033512 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033512 Vd NA 1.399 L/kg 1compartment NA NA Human Human DTXSID8033512 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8033512 TK.Half.Life NA 4.432 hours 1compartment NA NA Human Human -DTXSID8033512 Css NA 0.478 mg/L 3compartmentss NA 50% Human Human -DTXSID8033512 Css NA 3.405 mg/L 3compartmentss NA 95% Human Human -DTXSID8033512 Css NA 0.3158 mg/L PBTK NA 50% Human Human -DTXSID8033512 Css NA 2.121 mg/L PBTK NA 95% Human Human -DTXSID8033512 Clint NA 11.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033512 Fup NA 0.1151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033512 Vd NA 0.9135 L/kg 1compartment NA NA Rat Human +DTXSID8033512 TK.Half.Life NA 2.764 hours 1compartment NA NA Human Human +DTXSID8033512 Css NA 0.1476 mg/L 3compartmentss NA 50% Human Human +DTXSID8033512 Css NA 1.041 mg/L 3compartmentss NA 95% Human Human +DTXSID8033512 Css NA 0.1029 mg/L PBTK NA 50% Human Human +DTXSID8033512 Css NA 0.6862 mg/L PBTK NA 95% Human Human +DTXSID8033512 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033512 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033512 Vd NA 1.099 L/kg 1compartment NA NA Rat Human DTXSID8033512 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8033512 TK.Half.Life NA 1.9 hours 1compartment NA NA Rat Human -DTXSID8033512 Css NA 0.2592 mg/L 3compartmentss NA 50% Rat Human -DTXSID8033512 Css NA 1.376 mg/L 3compartmentss NA 95% Rat Human -DTXSID8033512 Css NA 0.1613 mg/L PBTK NA 50% Rat Human -DTXSID8033512 Css NA 0.799 mg/L PBTK NA 95% Rat Human +DTXSID8033512 TK.Half.Life NA 1.105 hours 1compartment NA NA Rat Human +DTXSID8033512 Css NA 0.0189 mg/L 3compartmentss NA 50% Rat Human +DTXSID8033512 Css NA 0.1008 mg/L 3compartmentss NA 95% Rat Human +DTXSID8033512 Css NA 0.01309 mg/L PBTK NA 50% Rat Human +DTXSID8033512 Css NA 0.06547 mg/L PBTK NA 95% Rat Human DTXSID8033562 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8033562 Fup 0.166 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8033562 Vd NA 1.834 L/kg 1compartment NA NA Human Human DTXSID8033562 Days.Css NA 22 Days PBTK NA NA Human Human DTXSID8033562 TK.Half.Life NA 114.8 hours 1compartment NA NA Human Human -DTXSID8033562 Css NA 6.901 mg/L 3compartmentss NA 50% Human Human -DTXSID8033562 Css NA 20.17 mg/L 3compartmentss NA 95% Human Human -DTXSID8033562 Css NA 4.938 mg/L PBTK NA 50% Human Human -DTXSID8033562 Css NA 13.26 mg/L PBTK NA 95% Human Human +DTXSID8033562 Css NA 6.691 mg/L 3compartmentss NA 50% Human Human +DTXSID8033562 Css NA 19.25 mg/L 3compartmentss NA 95% Human Human +DTXSID8033562 Css NA 4.809 mg/L PBTK NA 50% Human Human +DTXSID8033562 Css NA 12.61 mg/L PBTK NA 95% Human Human DTXSID8033562 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8033562 Fup 0.166 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8033562 Vd NA 1.414 L/kg 1compartment NA NA Rat Human -DTXSID8033562 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID8033562 TK.Half.Life NA 21.5 hours 1compartment NA NA Rat Human -DTXSID8033562 Css NA 1.893 mg/L 3compartmentss NA 50% Rat Human -DTXSID8033562 Css NA 4.385 mg/L 3compartmentss NA 95% Rat Human -DTXSID8033562 Css NA 1.296 mg/L PBTK NA 50% Rat Human -DTXSID8033562 Css NA 2.674 mg/L PBTK NA 95% Rat Human -DTXSID8033564 Clint NA 1.691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033564 Fup NA 0.1189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033564 Vd NA 0.3923 L/kg 1compartment NA NA Human Human +DTXSID8033562 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8033562 TK.Half.Life NA 5.94 hours 1compartment NA NA Rat Human +DTXSID8033562 Css NA 0.1172 mg/L 3compartmentss NA 50% Rat Human +DTXSID8033562 Css NA 0.362 mg/L 3compartmentss NA 95% Rat Human +DTXSID8033562 Css NA 0.08324 mg/L PBTK NA 50% Rat Human +DTXSID8033562 Css NA 0.2376 mg/L PBTK NA 95% Rat Human +DTXSID8033564 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033564 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033564 Vd NA 0.6085 L/kg 1compartment NA NA Human Human DTXSID8033564 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8033564 TK.Half.Life NA 5.781 hours 1compartment NA NA Human Human -DTXSID8033564 Css NA 2.204 mg/L 3compartmentss NA 50% Human Human -DTXSID8033564 Css NA 12.48 mg/L 3compartmentss NA 95% Human Human -DTXSID8033564 Css NA 1.413 mg/L PBTK NA 50% Human Human -DTXSID8033564 Css NA 7.481 mg/L PBTK NA 95% Human Human -DTXSID8033564 Clint NA 1.691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033564 Fup NA 0.1189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033564 Vd NA 0.373 L/kg 1compartment NA NA Rat Human +DTXSID8033564 TK.Half.Life NA 1.148 hours 1compartment NA NA Human Human +DTXSID8033564 Css NA 0.156 mg/L 3compartmentss NA 50% Human Human +DTXSID8033564 Css NA 1.246 mg/L 3compartmentss NA 95% Human Human +DTXSID8033564 Css NA 0.1083 mg/L PBTK NA 50% Human Human +DTXSID8033564 Css NA 0.8068 mg/L PBTK NA 95% Human Human +DTXSID8033564 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033564 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033564 Vd NA 0.5528 L/kg 1compartment NA NA Rat Human DTXSID8033564 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8033564 TK.Half.Life NA 2.965 hours 1compartment NA NA Rat Human -DTXSID8033564 Css NA 0.9835 mg/L 3compartmentss NA 50% Rat Human -DTXSID8033564 Css NA 4.597 mg/L 3compartmentss NA 95% Rat Human -DTXSID8033564 Css NA 0.6005 mg/L PBTK NA 50% Rat Human -DTXSID8033564 Css NA 2.576 mg/L PBTK NA 95% Rat Human -DTXSID8033566 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033566 Fup NA 0.7156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033566 Vd NA 0.5553 L/kg 1compartment NA NA Human Human -DTXSID8033566 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8033566 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human -DTXSID8033566 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human -DTXSID8033566 Css NA 6.927 mg/L 3compartmentss NA 95% Human Human -DTXSID8033566 Css NA 0.8629 mg/L PBTK NA 50% Human Human -DTXSID8033566 Css NA 4.361 mg/L PBTK NA 95% Human Human -DTXSID8033566 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033566 Fup NA 0.7156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033566 Vd NA 0.5995 L/kg 1compartment NA NA Rat Human -DTXSID8033566 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8033566 TK.Half.Life NA 1.847 hours 1compartment NA NA Rat Human -DTXSID8033566 Css NA 0.2928 mg/L 3compartmentss NA 50% Rat Human -DTXSID8033566 Css NA 1.822 mg/L 3compartmentss NA 95% Rat Human -DTXSID8033566 Css NA 0.2184 mg/L PBTK NA 50% Rat Human -DTXSID8033566 Css NA 1.061 mg/L PBTK NA 95% Rat Human -DTXSID8033649 Clint NA 0.002234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033649 Fup NA 0.5124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033649 Vd NA 0.3712 L/kg 1compartment NA NA Human Human +DTXSID8033564 TK.Half.Life NA 0.5934 hours 1compartment NA NA Rat Human +DTXSID8033564 Css NA 0.01967 mg/L 3compartmentss NA 50% Rat Human +DTXSID8033564 Css NA 0.1275 mg/L 3compartmentss NA 95% Rat Human +DTXSID8033564 Css NA 0.01355 mg/L PBTK NA 50% Rat Human +DTXSID8033564 Css NA 0.07952 mg/L PBTK NA 95% Rat Human +DTXSID8033649 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033649 Fup 0.825 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033649 Vd NA 0.7604 L/kg 1compartment NA NA Human Human DTXSID8033649 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8033649 TK.Half.Life NA 4.668 hours 1compartment NA NA Human Human -DTXSID8033649 Css NA 1.544 mg/L 3compartmentss NA 50% Human Human -DTXSID8033649 Css NA 7.851 mg/L 3compartmentss NA 95% Human Human -DTXSID8033649 Css NA 1.084 mg/L PBTK NA 50% Human Human -DTXSID8033649 Css NA 4.808 mg/L PBTK NA 95% Human Human -DTXSID8033649 Clint NA 0.002234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033649 Fup NA 0.5124 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033649 Vd NA 0.3849 L/kg 1compartment NA NA Rat Human +DTXSID8033649 TK.Half.Life NA 5.975 hours 1compartment NA NA Human Human +DTXSID8033649 Css NA 0.8242 mg/L 3compartmentss NA 50% Human Human +DTXSID8033649 Css NA 4.977 mg/L 3compartmentss NA 95% Human Human +DTXSID8033649 Css NA 0.687 mg/L PBTK NA 50% Human Human +DTXSID8033649 Css NA 3.201 mg/L PBTK NA 95% Human Human +DTXSID8033649 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033649 Fup 0.825 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033649 Vd NA 0.7836 L/kg 1compartment NA NA Rat Human DTXSID8033649 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8033649 TK.Half.Life NA 1.653 hours 1compartment NA NA Rat Human -DTXSID8033649 Css NA 0.4258 mg/L 3compartmentss NA 50% Rat Human -DTXSID8033649 Css NA 1.986 mg/L 3compartmentss NA 95% Rat Human -DTXSID8033649 Css NA 0.2818 mg/L PBTK NA 50% Rat Human -DTXSID8033649 Css NA 1.133 mg/L PBTK NA 95% Rat Human -DTXSID8033803 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033803 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8033803 Vd NA 1.938 L/kg 1compartment NA NA Human Human -DTXSID8033803 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8033803 TK.Half.Life NA 1.232 hours 1compartment NA NA Human Human -DTXSID8033803 Css NA 0.02503 mg/L 3compartmentss NA 50% Human Human -DTXSID8033803 Css NA 0.3122 mg/L 3compartmentss NA 95% Human Human -DTXSID8033803 Css NA 0.02542 mg/L PBTK NA 50% Human Human -DTXSID8033803 Css NA 0.27 mg/L PBTK NA 95% Human Human -DTXSID8033803 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033803 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8033803 Vd NA 1.974 L/kg 1compartment NA NA Rat Human +DTXSID8033649 TK.Half.Life NA 2.095 hours 1compartment NA NA Rat Human +DTXSID8033649 Css NA 0.01541 mg/L 3compartmentss NA 50% Rat Human +DTXSID8033649 Css NA 0.1185 mg/L 3compartmentss NA 95% Rat Human +DTXSID8033649 Css NA 0.01229 mg/L PBTK NA 50% Rat Human +DTXSID8033649 Css NA 0.07843 mg/L PBTK NA 95% Rat Human +DTXSID8033803 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033803 Fup 0.753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8033803 Vd NA 1.48 L/kg 1compartment NA NA Human Human +DTXSID8033803 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8033803 TK.Half.Life NA 12.72 hours 1compartment NA NA Human Human +DTXSID8033803 Css NA 0.8674 mg/L 3compartmentss NA 50% Human Human +DTXSID8033803 Css NA 5.872 mg/L 3compartmentss NA 95% Human Human +DTXSID8033803 Css NA 0.8191 mg/L PBTK NA 50% Human Human +DTXSID8033803 Css NA 3.887 mg/L PBTK NA 95% Human Human +DTXSID8033803 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033803 Fup 0.753 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8033803 Vd NA 1.509 L/kg 1compartment NA NA Rat Human DTXSID8033803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8033803 TK.Half.Life NA 0.6261 hours 1compartment NA NA Rat Human -DTXSID8033803 Css NA 0.01232 mg/L 3compartmentss NA 50% Rat Human -DTXSID8033803 Css NA 0.1226 mg/L 3compartmentss NA 95% Rat Human -DTXSID8033803 Css NA 0.0126 mg/L PBTK NA 50% Rat Human -DTXSID8033803 Css NA 0.09553 mg/L PBTK NA 95% Rat Human -DTXSID8034085 Clint NA 143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034085 Fup NA 0.0296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034085 Vd NA 2.946 L/kg 1compartment NA NA Human Human -DTXSID8034085 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8034085 TK.Half.Life NA 9.165 hours 1compartment NA NA Human Human -DTXSID8034085 Css NA 0.3054 mg/L 3compartmentss NA 50% Human Human -DTXSID8034085 Css NA 2.078 mg/L 3compartmentss NA 95% Human Human -DTXSID8034085 Css NA 0.2084 mg/L PBTK NA 50% Human Human -DTXSID8034085 Css NA 1.361 mg/L PBTK NA 95% Human Human -DTXSID8034085 Clint NA 143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034085 Fup NA 0.0296 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034085 Vd NA 2.206 L/kg 1compartment NA NA Rat Human -DTXSID8034085 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034085 TK.Half.Life NA 1.896 hours 1compartment NA NA Rat Human -DTXSID8034085 Css NA 0.1729 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034085 Css NA 0.9501 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034085 Css NA 0.1126 mg/L PBTK NA 50% Rat Human -DTXSID8034085 Css NA 0.5961 mg/L PBTK NA 95% Rat Human +DTXSID8033803 TK.Half.Life NA 4.418 hours 1compartment NA NA Rat Human +DTXSID8033803 Css NA 0.05043 mg/L 3compartmentss NA 50% Rat Human +DTXSID8033803 Css NA 0.3469 mg/L 3compartmentss NA 95% Rat Human +DTXSID8033803 Css NA 0.04858 mg/L PBTK NA 50% Rat Human +DTXSID8033803 Css NA 0.2246 mg/L PBTK NA 95% Rat Human DTXSID8034087 Clint NA 22.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8034087 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034087 Vd NA 0.8511 L/kg 1compartment NA NA Human Human +DTXSID8034087 Vd NA 0.9165 L/kg 1compartment NA NA Human Human DTXSID8034087 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8034087 TK.Half.Life NA 0.5859 hours 1compartment NA NA Human Human -DTXSID8034087 Css NA 0.02276 mg/L 3compartmentss NA 50% Human Human -DTXSID8034087 Css NA 0.2873 mg/L 3compartmentss NA 95% Human Human -DTXSID8034087 Css NA 0.01923 mg/L PBTK NA 50% Human Human -DTXSID8034087 Css NA 0.2176 mg/L PBTK NA 95% Human Human +DTXSID8034087 TK.Half.Life NA 0.6233 hours 1compartment NA NA Human Human +DTXSID8034087 Css NA 0.02 mg/L 3compartmentss NA 50% Human Human +DTXSID8034087 Css NA 0.2608 mg/L 3compartmentss NA 95% Human Human +DTXSID8034087 Css NA 0.01707 mg/L PBTK NA 50% Human Human +DTXSID8034087 Css NA 0.195 mg/L PBTK NA 95% Human Human DTXSID8034087 Clint NA 22.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8034087 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034087 Vd NA 0.8786 L/kg 1compartment NA NA Rat Human +DTXSID8034087 Vd NA 0.9339 L/kg 1compartment NA NA Rat Human DTXSID8034087 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034087 TK.Half.Life NA 0.2874 hours 1compartment NA NA Rat Human -DTXSID8034087 Css NA 0.01135 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034087 Css NA 0.1091 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034087 Css NA 0.009521 mg/L PBTK NA 50% Rat Human -DTXSID8034087 Css NA 0.0786 mg/L PBTK NA 95% Rat Human -DTXSID8034241 Clint NA 5.043 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034241 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034241 Vd NA 0.2744 L/kg 1compartment NA NA Human Human -DTXSID8034241 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8034241 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human -DTXSID8034241 Css NA 4.07 mg/L 3compartmentss NA 50% Human Human -DTXSID8034241 Css NA 31.11 mg/L 3compartmentss NA 95% Human Human -DTXSID8034241 Css NA 2.442 mg/L PBTK NA 50% Human Human -DTXSID8034241 Css NA 18.28 mg/L PBTK NA 95% Human Human -DTXSID8034241 Clint NA 5.043 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034241 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034241 Vd NA 0.268 L/kg 1compartment NA NA Rat Human +DTXSID8034087 TK.Half.Life NA 0.3023 hours 1compartment NA NA Rat Human +DTXSID8034087 Css NA 0.00235 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034087 Css NA 0.02445 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034087 Css NA 0.002092 mg/L PBTK NA 50% Rat Human +DTXSID8034087 Css NA 0.01805 mg/L PBTK NA 95% Rat Human +DTXSID8034089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034089 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034089 Vd NA 0.4946 L/kg 1compartment NA NA Human Human +DTXSID8034089 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8034089 TK.Half.Life NA 2.499 hours 1compartment NA NA Human Human +DTXSID8034089 Css NA 0.7513 mg/L 3compartmentss NA 50% Human Human +DTXSID8034089 Css NA 7.12 mg/L 3compartmentss NA 95% Human Human +DTXSID8034089 Css NA 0.4613 mg/L PBTK NA 50% Human Human +DTXSID8034089 Css NA 4.304 mg/L PBTK NA 95% Human Human +DTXSID8034089 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034089 Fup 0.0402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034089 Vd NA 0.4109 L/kg 1compartment NA NA Rat Human +DTXSID8034089 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8034089 TK.Half.Life NA 1.298 hours 1compartment NA NA Rat Human +DTXSID8034089 Css NA 0.09959 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034089 Css NA 0.7478 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034089 Css NA 0.05957 mg/L PBTK NA 50% Rat Human +DTXSID8034089 Css NA 0.4298 mg/L PBTK NA 95% Rat Human +DTXSID8034241 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034241 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034241 Vd NA 0.3675 L/kg 1compartment NA NA Human Human +DTXSID8034241 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8034241 TK.Half.Life NA 13.67 hours 1compartment NA NA Human Human +DTXSID8034241 Css NA 4.456 mg/L 3compartmentss NA 50% Human Human +DTXSID8034241 Css NA 15.95 mg/L 3compartmentss NA 95% Human Human +DTXSID8034241 Css NA 2.924 mg/L PBTK NA 50% Human Human +DTXSID8034241 Css NA 9.786 mg/L PBTK NA 95% Human Human +DTXSID8034241 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034241 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034241 Vd NA 0.3717 L/kg 1compartment NA NA Rat Human DTXSID8034241 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034241 TK.Half.Life NA 3.749 hours 1compartment NA NA Rat Human -DTXSID8034241 Css NA 2.121 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034241 Css NA 12.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034241 Css NA 1.202 mg/L PBTK NA 50% Rat Human -DTXSID8034241 Css NA 7.07 mg/L PBTK NA 95% Rat Human -DTXSID8034324 Clint NA 203 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034324 Fup NA 0.0291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034324 Vd NA 1.057 L/kg 1compartment NA NA Human Human +DTXSID8034241 TK.Half.Life NA 4.709 hours 1compartment NA NA Rat Human +DTXSID8034241 Css NA 0.2889 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034241 Css NA 0.8544 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034241 Css NA 0.185 mg/L PBTK NA 50% Rat Human +DTXSID8034241 Css NA 0.5034 mg/L PBTK NA 95% Rat Human +DTXSID8034324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034324 Fup 0.0634 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034324 Vd NA 1.526 L/kg 1compartment NA NA Human Human DTXSID8034324 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8034324 TK.Half.Life NA 1.629 hours 1compartment NA NA Human Human -DTXSID8034324 Css NA 0.114 mg/L 3compartmentss NA 50% Human Human -DTXSID8034324 Css NA 1.161 mg/L 3compartmentss NA 95% Human Human -DTXSID8034324 Css NA 0.07038 mg/L PBTK NA 50% Human Human -DTXSID8034324 Css NA 0.6872 mg/L PBTK NA 95% Human Human -DTXSID8034324 Clint NA 203 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034324 Fup NA 0.0291 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034324 Vd NA 0.7933 L/kg 1compartment NA NA Rat Human +DTXSID8034324 TK.Half.Life NA 6.054 hours 1compartment NA NA Human Human +DTXSID8034324 Css NA 0.5001 mg/L 3compartmentss NA 50% Human Human +DTXSID8034324 Css NA 3.643 mg/L 3compartmentss NA 95% Human Human +DTXSID8034324 Css NA 0.3226 mg/L PBTK NA 50% Human Human +DTXSID8034324 Css NA 2.237 mg/L PBTK NA 95% Human Human +DTXSID8034324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034324 Fup 0.0634 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034324 Vd NA 1.153 L/kg 1compartment NA NA Rat Human DTXSID8034324 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034324 TK.Half.Life NA 0.6211 hours 1compartment NA NA Rat Human -DTXSID8034324 Css NA 0.06601 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034324 Css NA 0.5233 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034324 Css NA 0.03796 mg/L PBTK NA 50% Rat Human -DTXSID8034324 Css NA 0.2951 mg/L PBTK NA 95% Rat Human -DTXSID8034372 Clint NA 2.453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034372 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034372 Vd NA 0.2038 L/kg 1compartment NA NA Human Human -DTXSID8034372 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8034372 TK.Half.Life NA 12.9 hours 1compartment NA NA Human Human -DTXSID8034372 Css NA 11.44 mg/L 3compartmentss NA 50% Human Human -DTXSID8034372 Css NA 85.72 mg/L 3compartmentss NA 95% Human Human -DTXSID8034372 Css NA 6.767 mg/L PBTK NA 50% Human Human -DTXSID8034372 Css NA 49.6 mg/L PBTK NA 95% Human Human -DTXSID8034372 Clint NA 2.453 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034372 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034372 Vd NA 0.2011 L/kg 1compartment NA NA Rat Human +DTXSID8034324 TK.Half.Life NA 2.322 hours 1compartment NA NA Rat Human +DTXSID8034324 Css NA 0.06412 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034324 Css NA 0.3762 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034324 Css NA 0.04056 mg/L PBTK NA 50% Rat Human +DTXSID8034324 Css NA 0.2282 mg/L PBTK NA 95% Rat Human +DTXSID8034372 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034372 Fup 0.0862 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034372 Vd NA 0.2897 L/kg 1compartment NA NA Human Human +DTXSID8034372 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8034372 TK.Half.Life NA 2.109 hours 1compartment NA NA Human Human +DTXSID8034372 Css NA 0.5901 mg/L 3compartmentss NA 50% Human Human +DTXSID8034372 Css NA 4.413 mg/L 3compartmentss NA 95% Human Human +DTXSID8034372 Css NA 0.3631 mg/L PBTK NA 50% Human Human +DTXSID8034372 Css NA 2.587 mg/L PBTK NA 95% Human Human +DTXSID8034372 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034372 Fup 0.0862 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034372 Vd NA 0.2895 L/kg 1compartment NA NA Rat Human DTXSID8034372 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034372 TK.Half.Life NA 7.364 hours 1compartment NA NA Rat Human -DTXSID8034372 Css NA 5.506 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034372 Css NA 33.57 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034372 Css NA 3.028 mg/L PBTK NA 50% Rat Human -DTXSID8034372 Css NA 18.19 mg/L PBTK NA 95% Rat Human -DTXSID8034376 Clint NA 21.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034376 Fup NA 0.9902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034376 Vd NA 3.151 L/kg 1compartment NA NA Human Human -DTXSID8034376 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8034376 TK.Half.Life NA 35.11 hours 1compartment NA NA Human Human -DTXSID8034376 Css NA 1.29 mg/L 3compartmentss NA 50% Human Human -DTXSID8034376 Css NA 9.089 mg/L 3compartmentss NA 95% Human Human -DTXSID8034376 Css NA 0.906 mg/L PBTK NA 50% Human Human -DTXSID8034376 Css NA 6.213 mg/L PBTK NA 95% Human Human -DTXSID8034376 Clint NA 21.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034376 Fup NA 0.9902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034376 Vd NA 2.37 L/kg 1compartment NA NA Rat Human -DTXSID8034376 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8034376 TK.Half.Life NA 4.944 hours 1compartment NA NA Rat Human -DTXSID8034376 Css NA 0.7063 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034376 Css NA 4.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034376 Css NA 0.4769 mg/L PBTK NA 50% Rat Human -DTXSID8034376 Css NA 2.976 mg/L PBTK NA 95% Rat Human +DTXSID8034372 TK.Half.Life NA 1.294 hours 1compartment NA NA Rat Human +DTXSID8034372 Css NA 0.006067 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034372 Css NA 0.03933 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034372 Css NA 0.003491 mg/L PBTK NA 50% Rat Human +DTXSID8034372 Css NA 0.02187 mg/L PBTK NA 95% Rat Human +DTXSID8034376 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034376 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034376 Vd NA 1.376 L/kg 1compartment NA NA Human Human +DTXSID8034376 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8034376 TK.Half.Life NA 2.153 hours 1compartment NA NA Human Human +DTXSID8034376 Css NA 0.0977 mg/L 3compartmentss NA 50% Human Human +DTXSID8034376 Css NA 0.6765 mg/L 3compartmentss NA 95% Human Human +DTXSID8034376 Css NA 0.07187 mg/L PBTK NA 50% Human Human +DTXSID8034376 Css NA 0.4682 mg/L PBTK NA 95% Human Human +DTXSID8034376 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034376 Fup 0.233 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034376 Vd NA 1.124 L/kg 1compartment NA NA Rat Human +DTXSID8034376 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8034376 TK.Half.Life NA 0.8936 hours 1compartment NA NA Rat Human +DTXSID8034376 Css NA 0.01231 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034376 Css NA 0.06602 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034376 Css NA 0.008948 mg/L PBTK NA 50% Rat Human +DTXSID8034376 Css NA 0.04467 mg/L PBTK NA 95% Rat Human DTXSID8034401 Clint 18.47 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8034401 Fup 0.0003605 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8034401 Vd NA 0.5318 L/kg 1compartment NA NA Human Human DTXSID8034401 Days.Css NA 25 Days PBTK NA NA Human Human DTXSID8034401 TK.Half.Life NA 115.8 hours 1compartment NA NA Human Human -DTXSID8034401 Css NA 40.11 mg/L 3compartmentss NA 50% Human Human -DTXSID8034401 Css NA 272.1 mg/L 3compartmentss NA 95% Human Human -DTXSID8034401 Css NA 23.43 mg/L PBTK NA 50% Human Human -DTXSID8034401 Css NA 157.8 mg/L PBTK NA 95% Human Human +DTXSID8034401 Css NA 39.2 mg/L 3compartmentss NA 50% Human Human +DTXSID8034401 Css NA 278.7 mg/L 3compartmentss NA 95% Human Human +DTXSID8034401 Css NA 22.79 mg/L PBTK NA 50% Human Human +DTXSID8034401 Css NA 163.4 mg/L PBTK NA 95% Human Human DTXSID8034401 Clint 18.47 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8034401 Fup 0.0003605 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8034401 Vd NA 0.3934 L/kg 1compartment NA NA Rat Human DTXSID8034401 Days.Css NA 11 Days PBTK NA NA Rat Human DTXSID8034401 TK.Half.Life NA 57.1 hours 1compartment NA NA Rat Human -DTXSID8034401 Css NA 24.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034401 Css NA 109.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034401 Css NA 13.15 mg/L PBTK NA 50% Rat Human -DTXSID8034401 Css NA 59.55 mg/L PBTK NA 95% Rat Human -DTXSID8034538 Clint NA 0.1784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034538 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034538 Vd NA 0.336 L/kg 1compartment NA NA Human Human -DTXSID8034538 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID8034538 TK.Half.Life NA 67.89 hours 1compartment NA NA Human Human -DTXSID8034538 Css NA 33.72 mg/L 3compartmentss NA 50% Human Human -DTXSID8034538 Css NA 207.7 mg/L 3compartmentss NA 95% Human Human -DTXSID8034538 Css NA 20.07 mg/L PBTK NA 50% Human Human -DTXSID8034538 Css NA 121 mg/L PBTK NA 95% Human Human -DTXSID8034538 Clint NA 0.1784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034538 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034538 Vd NA 0.28 L/kg 1compartment NA NA Rat Human -DTXSID8034538 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID8034538 TK.Half.Life NA 21.76 hours 1compartment NA NA Rat Human -DTXSID8034538 Css NA 11.19 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034538 Css NA 61.69 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034538 Css NA 6.184 mg/L PBTK NA 50% Rat Human -DTXSID8034538 Css NA 33.46 mg/L PBTK NA 95% Rat Human +DTXSID8034401 Css NA 5.433 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034401 Css NA 26.56 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034401 Css NA 3.067 mg/L PBTK NA 50% Rat Human +DTXSID8034401 Css NA 14.94 mg/L PBTK NA 95% Rat Human +DTXSID8034538 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034538 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034538 Vd NA 0.3323 L/kg 1compartment NA NA Human Human +DTXSID8034538 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8034538 TK.Half.Life NA 1.457 hours 1compartment NA NA Human Human +DTXSID8034538 Css NA 0.5412 mg/L 3compartmentss NA 50% Human Human +DTXSID8034538 Css NA 3.571 mg/L 3compartmentss NA 95% Human Human +DTXSID8034538 Css NA 0.3382 mg/L PBTK NA 50% Human Human +DTXSID8034538 Css NA 2.169 mg/L PBTK NA 95% Human Human +DTXSID8034538 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034538 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034538 Vd NA 0.3194 L/kg 1compartment NA NA Rat Human +DTXSID8034538 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8034538 TK.Half.Life NA 0.8329 hours 1compartment NA NA Rat Human +DTXSID8034538 Css NA 0.06587 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034538 Css NA 0.3107 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034538 Css NA 0.04031 mg/L PBTK NA 50% Rat Human +DTXSID8034538 Css NA 0.1829 mg/L PBTK NA 95% Rat Human DTXSID8034580 Clint 17.64 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8034580 Fup 0.1313 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8034580 Vd NA 1.665 L/kg 1compartment NA NA Human Human DTXSID8034580 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8034580 TK.Half.Life NA 4.435 hours 1compartment NA NA Human Human -DTXSID8034580 Css NA 0.2767 mg/L 3compartmentss NA 50% Human Human -DTXSID8034580 Css NA 2.032 mg/L 3compartmentss NA 95% Human Human -DTXSID8034580 Css NA 0.2082 mg/L PBTK NA 50% Human Human -DTXSID8034580 Css NA 1.4 mg/L PBTK NA 95% Human Human +DTXSID8034580 Css NA 0.234 mg/L 3compartmentss NA 50% Human Human +DTXSID8034580 Css NA 1.62 mg/L 3compartmentss NA 95% Human Human +DTXSID8034580 Css NA 0.1991 mg/L PBTK NA 50% Human Human +DTXSID8034580 Css NA 1.379 mg/L PBTK NA 95% Human Human DTXSID8034580 Clint 56.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8034580 Fup 0.1386 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8034580 Vd NA 1.31 L/kg 1compartment NA NA Rat Rat DTXSID8034580 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID8034580 TK.Half.Life NA 0.7841 hours 1compartment NA NA Rat Rat -DTXSID8034580 Css NA 0.04733 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8034580 Css NA 0.3004 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8034580 Css NA 0.03372 mg/L PBTK NA 50% Rat Rat -DTXSID8034580 Css NA 0.1929 mg/L PBTK NA 95% Rat Rat +DTXSID8034580 Css NA 0.008647 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8034580 Css NA 0.05554 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8034580 Css NA 0.007635 mg/L PBTK NA 50% Rat Rat +DTXSID8034580 Css NA 0.04898 mg/L PBTK NA 95% Rat Rat DTXSID8034586 Clint 18.48 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID8034586 Fup NA 0.0195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034586 Vd NA 1.796 L/kg 1compartment NA NA Human Human -DTXSID8034586 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8034586 TK.Half.Life NA 20.46 hours 1compartment NA NA Human Human -DTXSID8034586 Css NA 1.841 mg/L 3compartmentss NA 50% Human Human -DTXSID8034586 Css NA 14.6 mg/L 3compartmentss NA 95% Human Human -DTXSID8034586 Css NA 1.149 mg/L PBTK NA 50% Human Human -DTXSID8034586 Css NA 8.797 mg/L PBTK NA 95% Human Human +DTXSID8034586 Fup 0.00892 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034586 Vd NA 3.047 L/kg 1compartment NA NA Human Human +DTXSID8034586 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID8034586 TK.Half.Life NA 96.53 hours 1compartment NA NA Human Human +DTXSID8034586 Css NA 4.168 mg/L 3compartmentss NA 50% Human Human +DTXSID8034586 Css NA 25.43 mg/L 3compartmentss NA 95% Human Human +DTXSID8034586 Css NA 2.682 mg/L PBTK NA 50% Human Human +DTXSID8034586 Css NA 16.37 mg/L PBTK NA 95% Human Human DTXSID8034586 Clint 42.28 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8034586 Fup 0.00603 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID8034586 Vd NA 0.7886 L/kg 1compartment NA NA Rat Rat -DTXSID8034586 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8034586 TK.Half.Life NA 5.411 hours 1compartment NA NA Rat Rat -DTXSID8034586 Css NA 1.079 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8034586 Css NA 9.107 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8034586 Css NA 0.6457 mg/L PBTK NA 50% Rat Rat -DTXSID8034586 Css NA 5.097 mg/L PBTK NA 95% Rat Rat +DTXSID8034586 Vd 2.8 2.249 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID8034586 Days.Css NA 3 Days PBTK NA NA Rat Rat +DTXSID8034586 TK.Half.Life 0.24 7.089 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID8034586 Css 0.005 0.2349 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID8034586 Css 0.005 1.216 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID8034586 Css 0.005 0.1565 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID8034586 Css 0.005 0.8101 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID8034588 Clint 16.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8034588 Fup 0.0097 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8034588 Vd NA 2.627 L/kg 1compartment NA NA Human Human DTXSID8034588 Days.Css NA 9 Days PBTK NA NA Human Human DTXSID8034588 TK.Half.Life NA 64.72 hours 1compartment NA NA Human Human -DTXSID8034588 Css NA 2.98 mg/L 3compartmentss NA 50% Human Human -DTXSID8034588 Css NA 18.86 mg/L 3compartmentss NA 95% Human Human -DTXSID8034588 Css NA 2 mg/L PBTK NA 50% Human Human -DTXSID8034588 Css NA 12.2 mg/L PBTK NA 95% Human Human +DTXSID8034588 Css NA 2.901 mg/L 3compartmentss NA 50% Human Human +DTXSID8034588 Css NA 18.38 mg/L 3compartmentss NA 95% Human Human +DTXSID8034588 Css NA 1.955 mg/L PBTK NA 50% Human Human +DTXSID8034588 Css NA 12.14 mg/L PBTK NA 95% Human Human DTXSID8034588 Clint 16.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8034588 Fup 0.0097 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8034588 Vd NA 1.958 L/kg 1compartment NA NA Rat Human DTXSID8034588 Days.Css NA 5 Days PBTK NA NA Rat Human DTXSID8034588 TK.Half.Life NA 14.37 hours 1compartment NA NA Rat Human -DTXSID8034588 Css NA 1.659 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034588 Css NA 8.575 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034588 Css NA 1.067 mg/L PBTK NA 50% Rat Human -DTXSID8034588 Css NA 5.401 mg/L PBTK NA 95% Rat Human +DTXSID8034588 Css NA 0.372 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034588 Css NA 2.03 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034588 Css NA 0.2485 mg/L PBTK NA 50% Rat Human +DTXSID8034588 Css NA 1.314 mg/L PBTK NA 95% Rat Human DTXSID8034665 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8034665 Fup 0.9231 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID8034665 Vd NA 0.9615 L/kg 1compartment NA NA Human Human +DTXSID8034665 Vd NA 0.5814 L/kg 1compartment NA NA Human Human DTXSID8034665 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8034665 TK.Half.Life NA 6.816 hours 1compartment NA NA Human Human -DTXSID8034665 Css NA 0.8386 mg/L 3compartmentss NA 50% Human Human -DTXSID8034665 Css NA 3.073 mg/L 3compartmentss NA 95% Human Human -DTXSID8034665 Css NA 0.7313 mg/L PBTK NA 50% Human Human -DTXSID8034665 Css NA 2.216 mg/L PBTK NA 95% Human Human +DTXSID8034665 TK.Half.Life NA 4.075 hours 1compartment NA NA Human Human +DTXSID8034665 Css NA 0.608 mg/L 3compartmentss NA 50% Human Human +DTXSID8034665 Css NA 2.293 mg/L 3compartmentss NA 95% Human Human +DTXSID8034665 Css NA 0.4781 mg/L PBTK NA 50% Human Human +DTXSID8034665 Css NA 1.563 mg/L PBTK NA 95% Human Human DTXSID8034665 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8034665 Fup 0.9231 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID8034665 Vd NA 0.9625 L/kg 1compartment NA NA Rat Human +DTXSID8034665 Vd NA 0.5985 L/kg 1compartment NA NA Rat Human DTXSID8034665 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034665 TK.Half.Life NA 2.305 hours 1compartment NA NA Rat Human -DTXSID8034665 Css NA 0.2137 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034665 Css NA 0.7888 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034665 Css NA 0.1835 mg/L PBTK NA 50% Rat Human -DTXSID8034665 Css NA 0.5155 mg/L PBTK NA 95% Rat Human -DTXSID8034669 Clint NA 72.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034669 Fup NA 0.2059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034669 Vd NA 2.259 L/kg 1compartment NA NA Human Human +DTXSID8034665 TK.Half.Life NA 1.429 hours 1compartment NA NA Rat Human +DTXSID8034665 Css NA 0.00389 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034665 Css NA 0.01939 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034665 Css NA 0.002942 mg/L PBTK NA 50% Rat Human +DTXSID8034665 Css NA 0.01308 mg/L PBTK NA 95% Rat Human +DTXSID8034669 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034669 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034669 Vd NA 2.253 L/kg 1compartment NA NA Human Human DTXSID8034669 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8034669 TK.Half.Life NA 2.749 hours 1compartment NA NA Human Human -DTXSID8034669 Css NA 0.05609 mg/L 3compartmentss NA 50% Human Human -DTXSID8034669 Css NA 0.372 mg/L 3compartmentss NA 95% Human Human -DTXSID8034669 Css NA 0.04087 mg/L PBTK NA 50% Human Human -DTXSID8034669 Css NA 0.2611 mg/L PBTK NA 95% Human Human -DTXSID8034669 Clint NA 72.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034669 Fup NA 0.2059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034669 Vd NA 1.732 L/kg 1compartment NA NA Rat Human +DTXSID8034669 TK.Half.Life NA 5.082 hours 1compartment NA NA Human Human +DTXSID8034669 Css NA 0.1766 mg/L 3compartmentss NA 50% Human Human +DTXSID8034669 Css NA 1.162 mg/L 3compartmentss NA 95% Human Human +DTXSID8034669 Css NA 0.1292 mg/L PBTK NA 50% Human Human +DTXSID8034669 Css NA 0.8001 mg/L PBTK NA 95% Human Human +DTXSID8034669 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034669 Fup 0.204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034669 Vd NA 1.727 L/kg 1compartment NA NA Rat Human DTXSID8034669 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034669 TK.Half.Life NA 0.8854 hours 1compartment NA NA Rat Human -DTXSID8034669 Css NA 0.031 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034669 Css NA 0.1671 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034669 Css NA 0.02168 mg/L PBTK NA 50% Rat Human -DTXSID8034669 Css NA 0.1112 mg/L PBTK NA 95% Rat Human -DTXSID8034742 Clint NA 316.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034742 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034742 Vd NA 2.999 L/kg 1compartment NA NA Human Human -DTXSID8034742 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8034742 TK.Half.Life NA 6.217 hours 1compartment NA NA Human Human -DTXSID8034742 Css NA 0.1657 mg/L 3compartmentss NA 50% Human Human -DTXSID8034742 Css NA 1.067 mg/L 3compartmentss NA 95% Human Human -DTXSID8034742 Css NA 0.1134 mg/L PBTK NA 50% Human Human -DTXSID8034742 Css NA 0.7116 mg/L PBTK NA 95% Human Human -DTXSID8034742 Clint NA 316.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034742 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034742 Vd NA 2.246 L/kg 1compartment NA NA Rat Human -DTXSID8034742 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034742 TK.Half.Life NA 1.384 hours 1compartment NA NA Rat Human -DTXSID8034742 Css NA 0.09287 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034742 Css NA 0.4936 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034742 Css NA 0.06074 mg/L PBTK NA 50% Rat Human -DTXSID8034742 Css NA 0.3138 mg/L PBTK NA 95% Rat Human -DTXSID8034792 Clint NA 15.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034792 Fup NA 0.346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034792 Vd NA 0.4943 L/kg 1compartment NA NA Human Human +DTXSID8034669 TK.Half.Life NA 1.584 hours 1compartment NA NA Rat Human +DTXSID8034669 Css NA 0.02238 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034669 Css NA 0.1114 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034669 Css NA 0.01619 mg/L PBTK NA 50% Rat Human +DTXSID8034669 Css NA 0.07641 mg/L PBTK NA 95% Rat Human +DTXSID8034792 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034792 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034792 Vd NA 0.4042 L/kg 1compartment NA NA Human Human DTXSID8034792 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8034792 TK.Half.Life NA 0.705 hours 1compartment NA NA Human Human -DTXSID8034792 Css NA 0.08758 mg/L 3compartmentss NA 50% Human Human -DTXSID8034792 Css NA 0.6515 mg/L 3compartmentss NA 95% Human Human -DTXSID8034792 Css NA 0.06112 mg/L PBTK NA 50% Human Human -DTXSID8034792 Css NA 0.418 mg/L PBTK NA 95% Human Human -DTXSID8034792 Clint NA 15.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034792 Fup NA 0.346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034792 Vd NA 0.4807 L/kg 1compartment NA NA Rat Human +DTXSID8034792 TK.Half.Life NA 1.277 hours 1compartment NA NA Human Human +DTXSID8034792 Css NA 0.314 mg/L 3compartmentss NA 50% Human Human +DTXSID8034792 Css NA 1.829 mg/L 3compartmentss NA 95% Human Human +DTXSID8034792 Css NA 0.2074 mg/L PBTK NA 50% Human Human +DTXSID8034792 Css NA 1.149 mg/L PBTK NA 95% Human Human +DTXSID8034792 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034792 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034792 Vd NA 0.3924 L/kg 1compartment NA NA Rat Human DTXSID8034792 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034792 TK.Half.Life NA 0.3669 hours 1compartment NA NA Rat Human -DTXSID8034792 Css NA 0.04712 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034792 Css NA 0.254 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034792 Css NA 0.03134 mg/L PBTK NA 50% Rat Human -DTXSID8034792 Css NA 0.1547 mg/L PBTK NA 95% Rat Human -DTXSID8034823 Clint NA 37.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034823 Fup NA 0.0255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034823 Vd NA 1.406 L/kg 1compartment NA NA Human Human +DTXSID8034792 TK.Half.Life NA 0.7175 hours 1compartment NA NA Rat Human +DTXSID8034792 Css NA 0.03686 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034792 Css NA 0.1598 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034792 Css NA 0.02386 mg/L PBTK NA 50% Rat Human +DTXSID8034792 Css NA 0.09743 mg/L PBTK NA 95% Rat Human +DTXSID8034823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034823 Fup 0.0888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034823 Vd NA 2.1 L/kg 1compartment NA NA Human Human DTXSID8034823 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8034823 TK.Half.Life NA 6.822 hours 1compartment NA NA Human Human -DTXSID8034823 Css NA 0.6991 mg/L 3compartmentss NA 50% Human Human -DTXSID8034823 Css NA 6.381 mg/L 3compartmentss NA 95% Human Human -DTXSID8034823 Css NA 0.4368 mg/L PBTK NA 50% Human Human -DTXSID8034823 Css NA 3.846 mg/L PBTK NA 95% Human Human -DTXSID8034823 Clint NA 37.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034823 Fup NA 0.0255 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034823 Vd NA 1.046 L/kg 1compartment NA NA Rat Human +DTXSID8034823 TK.Half.Life NA 7.903 hours 1compartment NA NA Human Human +DTXSID8034823 Css NA 0.4246 mg/L 3compartmentss NA 50% Human Human +DTXSID8034823 Css NA 2.935 mg/L 3compartmentss NA 95% Human Human +DTXSID8034823 Css NA 0.2874 mg/L PBTK NA 50% Human Human +DTXSID8034823 Css NA 1.89 mg/L PBTK NA 95% Human Human +DTXSID8034823 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034823 Fup 0.0888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034823 Vd NA 1.585 L/kg 1compartment NA NA Rat Human DTXSID8034823 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8034823 TK.Half.Life NA 2.679 hours 1compartment NA NA Rat Human -DTXSID8034823 Css NA 0.3938 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034823 Css NA 2.966 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034823 Css NA 0.2314 mg/L PBTK NA 50% Rat Human -DTXSID8034823 Css NA 1.664 mg/L PBTK NA 95% Rat Human +DTXSID8034823 TK.Half.Life NA 2.513 hours 1compartment NA NA Rat Human +DTXSID8034823 Css NA 0.05516 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034823 Css NA 0.3072 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034823 Css NA 0.03659 mg/L PBTK NA 50% Rat Human +DTXSID8034823 Css NA 0.1926 mg/L PBTK NA 95% Rat Human DTXSID8034871 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8034871 Fup 0.435 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8034871 Vd NA 3.024 L/kg 1compartment NA NA Human Human DTXSID8034871 Days.Css NA 114 Days PBTK NA NA Human Human DTXSID8034871 TK.Half.Life NA 486.4 hours 1compartment NA NA Human Human -DTXSID8034871 Css NA 0.07348 mg/L 3compartmentss NA 50% Human Human -DTXSID8034871 Css NA 0.8188 mg/L 3compartmentss NA 95% Human Human -DTXSID8034871 Css NA 0.05414 mg/L PBTK NA 50% Human Human -DTXSID8034871 Css NA 0.5724 mg/L PBTK NA 95% Human Human +DTXSID8034871 Css NA 0.07076 mg/L 3compartmentss NA 50% Human Human +DTXSID8034871 Css NA 0.8268 mg/L 3compartmentss NA 95% Human Human +DTXSID8034871 Css NA 0.052 mg/L PBTK NA 50% Human Human +DTXSID8034871 Css NA 0.5848 mg/L PBTK NA 95% Human Human DTXSID8034871 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8034871 Fup 0.435 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8034871 Vd NA 2.294 L/kg 1compartment NA NA Rat Human DTXSID8034871 Days.Css NA 28 Days PBTK NA NA Rat Human DTXSID8034871 TK.Half.Life NA 38.81 hours 1compartment NA NA Rat Human -DTXSID8034871 Css NA 0.04245 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034871 Css NA 0.3752 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034871 Css NA 0.03007 mg/L PBTK NA 50% Rat Human -DTXSID8034871 Css NA 0.2491 mg/L PBTK NA 95% Rat Human -DTXSID8034873 Clint NA 31.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034873 Fup NA 0.053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8034873 Vd NA 2.905 L/kg 1compartment NA NA Human Human -DTXSID8034873 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8034873 TK.Half.Life NA 22.7 hours 1compartment NA NA Human Human -DTXSID8034873 Css NA 0.9444 mg/L 3compartmentss NA 50% Human Human -DTXSID8034873 Css NA 5.8 mg/L 3compartmentss NA 95% Human Human -DTXSID8034873 Css NA 0.6504 mg/L PBTK NA 50% Human Human -DTXSID8034873 Css NA 3.922 mg/L PBTK NA 95% Human Human -DTXSID8034873 Clint NA 31.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034873 Fup NA 0.053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8034873 Vd NA 2.178 L/kg 1compartment NA NA Rat Human -DTXSID8034873 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8034873 TK.Half.Life NA 4.268 hours 1compartment NA NA Rat Human -DTXSID8034873 Css NA 0.526 mg/L 3compartmentss NA 50% Rat Human -DTXSID8034873 Css NA 2.848 mg/L 3compartmentss NA 95% Rat Human -DTXSID8034873 Css NA 0.3444 mg/L PBTK NA 50% Rat Human -DTXSID8034873 Css NA 1.8 mg/L PBTK NA 95% Rat Human +DTXSID8034871 Css NA 0.009413 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034871 Css NA 0.08117 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034871 Css NA 0.006937 mg/L PBTK NA 50% Rat Human +DTXSID8034871 Css NA 0.05633 mg/L PBTK NA 95% Rat Human +DTXSID8034875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034875 Fup 0.0115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8034875 Vd NA 2.702 L/kg 1compartment NA NA Human Human +DTXSID8034875 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8034875 TK.Half.Life NA 49.37 hours 1compartment NA NA Human Human +DTXSID8034875 Css NA 2.481 mg/L 3compartmentss NA 50% Human Human +DTXSID8034875 Css NA 18.08 mg/L 3compartmentss NA 95% Human Human +DTXSID8034875 Css NA 1.659 mg/L PBTK NA 50% Human Human +DTXSID8034875 Css NA 11.46 mg/L PBTK NA 95% Human Human +DTXSID8034875 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034875 Fup 0.0115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8034875 Vd NA 2.016 L/kg 1compartment NA NA Rat Human +DTXSID8034875 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8034875 TK.Half.Life NA 10.43 hours 1compartment NA NA Rat Human +DTXSID8034875 Css NA 0.3203 mg/L 3compartmentss NA 50% Rat Human +DTXSID8034875 Css NA 2.066 mg/L 3compartmentss NA 95% Rat Human +DTXSID8034875 Css NA 0.2104 mg/L PBTK NA 50% Rat Human +DTXSID8034875 Css NA 1.29 mg/L PBTK NA 95% Rat Human DTXSID8034877 Clint 43.89 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8034877 Fup 0.01673 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8034877 Vd NA 0.704 L/kg 1compartment NA NA Human Human DTXSID8034877 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8034877 TK.Half.Life NA 3.84 hours 1compartment NA NA Human Human -DTXSID8034877 Css NA 0.777 mg/L 3compartmentss NA 50% Human Human -DTXSID8034877 Css NA 8.603 mg/L 3compartmentss NA 95% Human Human -DTXSID8034877 Css NA 0.5282 mg/L PBTK NA 50% Human Human -DTXSID8034877 Css NA 5.307 mg/L PBTK NA 95% Human Human +DTXSID8034877 Css NA 0.7413 mg/L 3compartmentss NA 50% Human Human +DTXSID8034877 Css NA 7.404 mg/L 3compartmentss NA 95% Human Human +DTXSID8034877 Css NA 0.5176 mg/L PBTK NA 50% Human Human +DTXSID8034877 Css NA 5.172 mg/L PBTK NA 95% Human Human DTXSID8034877 Clint 11.41 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8034877 Fup 0.07924 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8034877 Vd NA 1.15 L/kg 1compartment NA NA Rat Rat DTXSID8034877 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID8034877 TK.Half.Life NA 3.212 hours 1compartment NA NA Rat Rat -DTXSID8034877 Css NA 0.4083 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8034877 Css NA 2.158 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8034877 Css NA 0.2552 mg/L PBTK NA 50% Rat Rat -DTXSID8034877 Css NA 1.275 mg/L PBTK NA 95% Rat Rat +DTXSID8034877 Css NA 0.08311 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8034877 Css NA 0.4149 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8034877 Css NA 0.06014 mg/L PBTK NA 50% Rat Rat +DTXSID8034877 Css NA 0.3002 mg/L PBTK NA 95% Rat Rat DTXSID8034956 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8034956 Fup 0.02484 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8034956 Vd NA 1.764 L/kg 1compartment NA NA Human Human -DTXSID8034956 Days.Css NA 194 Days PBTK NA NA Human Human +DTXSID8034956 Days.Css NA 195 Days PBTK NA NA Human Human DTXSID8034956 TK.Half.Life NA 761.8 hours 1compartment NA NA Human Human -DTXSID8034956 Css NA 62.78 mg/L 3compartmentss NA 50% Human Human -DTXSID8034956 Css NA 310 mg/L 3compartmentss NA 95% Human Human -DTXSID8034956 Css NA 41.38 mg/L PBTK NA 50% Human Human -DTXSID8034956 Css NA 183.3 mg/L PBTK NA 95% Human Human +DTXSID8034956 Css NA 56.27 mg/L 3compartmentss NA 50% Human Human +DTXSID8034956 Css NA 247.7 mg/L 3compartmentss NA 95% Human Human +DTXSID8034956 Css NA 40.6 mg/L PBTK NA 50% Human Human +DTXSID8034956 Css NA 178.7 mg/L PBTK NA 95% Human Human DTXSID8034956 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8034956 Fup 0.05614 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID8034956 Vd NA 1.72 L/kg 1compartment NA NA Rat Rat DTXSID8034956 Days.Css NA 39 Days PBTK NA NA Rat Rat DTXSID8034956 TK.Half.Life NA 91.49 hours 1compartment NA NA Rat Rat -DTXSID8034956 Css NA 11.41 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8034956 Css NA 31.04 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8034956 Css NA 6.828 mg/L PBTK NA 50% Rat Rat -DTXSID8034956 Css NA 17.47 mg/L PBTK NA 95% Rat Rat -DTXSID8035001 Clint NA 0.4267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8035001 Fup NA 0.0782 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8035001 Vd NA 0.5673 L/kg 1compartment NA NA Human Human -DTXSID8035001 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8035001 TK.Half.Life NA 27.85 hours 1compartment NA NA Human Human -DTXSID8035001 Css NA 7.274 mg/L 3compartmentss NA 50% Human Human -DTXSID8035001 Css NA 36 mg/L 3compartmentss NA 95% Human Human -DTXSID8035001 Css NA 4.725 mg/L PBTK NA 50% Human Human -DTXSID8035001 Css NA 21.53 mg/L PBTK NA 95% Human Human -DTXSID8035001 Clint NA 0.4267 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8035001 Fup NA 0.0782 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8035001 Vd NA 0.4891 L/kg 1compartment NA NA Rat Human -DTXSID8035001 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8035001 TK.Half.Life NA 10.22 hours 1compartment NA NA Rat Human -DTXSID8035001 Css NA 2.687 mg/L 3compartmentss NA 50% Rat Human -DTXSID8035001 Css NA 11.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID8035001 Css NA 1.638 mg/L PBTK NA 50% Rat Human -DTXSID8035001 Css NA 6.268 mg/L PBTK NA 95% Rat Human -DTXSID8035138 Clint NA 0.1028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8035138 Fup NA 0.2182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8035138 Vd NA 0.29 L/kg 1compartment NA NA Human Human -DTXSID8035138 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8035138 TK.Half.Life NA 7.35 hours 1compartment NA NA Human Human -DTXSID8035138 Css NA 3.14 mg/L 3compartmentss NA 50% Human Human -DTXSID8035138 Css NA 11.47 mg/L 3compartmentss NA 95% Human Human -DTXSID8035138 Css NA 2.015 mg/L PBTK NA 50% Human Human -DTXSID8035138 Css NA 6.913 mg/L PBTK NA 95% Human Human -DTXSID8035138 Clint NA 0.1028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8035138 Fup NA 0.2182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8035138 Vd NA 0.2927 L/kg 1compartment NA NA Rat Human -DTXSID8035138 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8035138 TK.Half.Life NA 2.732 hours 1compartment NA NA Rat Human -DTXSID8035138 Css NA 0.969 mg/L 3compartmentss NA 50% Rat Human -DTXSID8035138 Css NA 2.975 mg/L 3compartmentss NA 95% Rat Human -DTXSID8035138 Css NA 0.584 mg/L PBTK NA 50% Rat Human -DTXSID8035138 Css NA 1.673 mg/L PBTK NA 95% Rat Human +DTXSID8034956 Css NA 2.115 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8034956 Css NA 5.537 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8034956 Css NA 1.581 mg/L PBTK NA 50% Rat Rat +DTXSID8034956 Css NA 4.138 mg/L PBTK NA 95% Rat Rat +DTXSID8035001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8035001 Fup 0.0887 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8035001 Vd NA 0.6055 L/kg 1compartment NA NA Human Human +DTXSID8035001 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8035001 TK.Half.Life NA 1.662 hours 1compartment NA NA Human Human +DTXSID8035001 Css NA 0.3024 mg/L 3compartmentss NA 50% Human Human +DTXSID8035001 Css NA 2.483 mg/L 3compartmentss NA 95% Human Human +DTXSID8035001 Css NA 0.2001 mg/L PBTK NA 50% Human Human +DTXSID8035001 Css NA 1.529 mg/L PBTK NA 95% Human Human +DTXSID8035001 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8035001 Fup 0.0887 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8035001 Vd NA 0.5221 L/kg 1compartment NA NA Rat Human +DTXSID8035001 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8035001 TK.Half.Life NA 0.8493 hours 1compartment NA NA Rat Human +DTXSID8035001 Css NA 0.03972 mg/L 3compartmentss NA 50% Rat Human +DTXSID8035001 Css NA 0.2577 mg/L 3compartmentss NA 95% Rat Human +DTXSID8035001 Css NA 0.02542 mg/L PBTK NA 50% Rat Human +DTXSID8035001 Css NA 0.1538 mg/L PBTK NA 95% Rat Human DTXSID8035180 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8035180 Fup 0.2902 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8035180 Vd NA 3.132 L/kg 1compartment NA NA Human Human DTXSID8035180 Days.Css NA 2454 Days PBTK NA NA Human Human DTXSID8035180 TK.Half.Life NA 8982 hours 1compartment NA NA Human Human -DTXSID8035180 Css NA 323.6 mg/L 3compartmentss NA 50% Human Human -DTXSID8035180 Css NA 887.2 mg/L 3compartmentss NA 95% Human Human -DTXSID8035180 Css NA 227.5 mg/L PBTK NA 50% Human Human -DTXSID8035180 Css NA 576 mg/L PBTK NA 95% Human Human +DTXSID8035180 Css NA 311.3 mg/L 3compartmentss NA 50% Human Human +DTXSID8035180 Css NA 851.4 mg/L 3compartmentss NA 95% Human Human +DTXSID8035180 Css NA 218.9 mg/L PBTK NA 50% Human Human +DTXSID8035180 Css NA 562.8 mg/L PBTK NA 95% Human Human DTXSID8035180 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8035180 Fup 0.2902 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8035180 Vd NA 2.349 L/kg 1compartment NA NA Rat Human -DTXSID8035180 Days.Css NA 626 Days PBTK NA NA Rat Human +DTXSID8035180 Days.Css NA 625 Days PBTK NA NA Rat Human DTXSID8035180 TK.Half.Life NA 560.8 hours 1compartment NA NA Rat Human -DTXSID8035180 Css NA 87.24 mg/L 3compartmentss NA 50% Rat Human -DTXSID8035180 Css NA 191.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID8035180 Css NA 58.64 mg/L PBTK NA 50% Rat Human -DTXSID8035180 Css NA 116.3 mg/L PBTK NA 95% Rat Human -DTXSID8035186 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8035186 Fup NA 0.8827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8035186 Vd NA 1.141 L/kg 1compartment NA NA Human Human +DTXSID8035180 Css NA 19.72 mg/L 3compartmentss NA 50% Rat Human +DTXSID8035180 Css NA 43.49 mg/L 3compartmentss NA 95% Rat Human +DTXSID8035180 Css NA 13.72 mg/L PBTK NA 50% Rat Human +DTXSID8035180 Css NA 27.3 mg/L PBTK NA 95% Rat Human +DTXSID8035184 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8035184 Fup 0.552 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8035184 Vd NA 0.4808 L/kg 1compartment NA NA Human Human +DTXSID8035184 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8035184 TK.Half.Life NA 5.64 hours 1compartment NA NA Human Human +DTXSID8035184 Css NA 1.371 mg/L 3compartmentss NA 50% Human Human +DTXSID8035184 Css NA 8.785 mg/L 3compartmentss NA 95% Human Human +DTXSID8035184 Css NA 1.017 mg/L PBTK NA 50% Human Human +DTXSID8035184 Css NA 5.399 mg/L PBTK NA 95% Human Human +DTXSID8035184 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8035184 Fup 0.552 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8035184 Vd NA 0.4855 L/kg 1compartment NA NA Rat Human +DTXSID8035184 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8035184 TK.Half.Life NA 1.939 hours 1compartment NA NA Rat Human +DTXSID8035184 Css NA 0.08402 mg/L 3compartmentss NA 50% Rat Human +DTXSID8035184 Css NA 0.4795 mg/L 3compartmentss NA 95% Rat Human +DTXSID8035184 Css NA 0.06163 mg/L PBTK NA 50% Rat Human +DTXSID8035184 Css NA 0.2863 mg/L PBTK NA 95% Rat Human +DTXSID8035186 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8035186 Fup 0.546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8035186 Vd NA 0.9874 L/kg 1compartment NA NA Human Human DTXSID8035186 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8035186 TK.Half.Life NA 8.681 hours 1compartment NA NA Human Human -DTXSID8035186 Css NA 0.8732 mg/L 3compartmentss NA 50% Human Human -DTXSID8035186 Css NA 5.061 mg/L 3compartmentss NA 95% Human Human -DTXSID8035186 Css NA 0.787 mg/L PBTK NA 50% Human Human -DTXSID8035186 Css NA 3.421 mg/L PBTK NA 95% Human Human -DTXSID8035186 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8035186 Fup NA 0.8827 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8035186 Vd NA 1.094 L/kg 1compartment NA NA Rat Human +DTXSID8035186 TK.Half.Life NA 0.9233 hours 1compartment NA NA Human Human +DTXSID8035186 Css NA 0.03533 mg/L 3compartmentss NA 50% Human Human +DTXSID8035186 Css NA 0.356 mg/L 3compartmentss NA 95% Human Human +DTXSID8035186 Css NA 0.02864 mg/L PBTK NA 50% Human Human +DTXSID8035186 Css NA 0.2439 mg/L PBTK NA 95% Human Human +DTXSID8035186 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8035186 Fup 0.546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8035186 Vd NA 0.9147 L/kg 1compartment NA NA Rat Human DTXSID8035186 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8035186 TK.Half.Life NA 2.757 hours 1compartment NA NA Rat Human -DTXSID8035186 Css NA 0.2205 mg/L 3compartmentss NA 50% Rat Human -DTXSID8035186 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID8035186 Css NA 0.1938 mg/L PBTK NA 50% Rat Human -DTXSID8035186 Css NA 0.8242 mg/L PBTK NA 95% Rat Human +DTXSID8035186 TK.Half.Life NA 0.4255 hours 1compartment NA NA Rat Human +DTXSID8035186 Css NA 0.004323 mg/L 3compartmentss NA 50% Rat Human +DTXSID8035186 Css NA 0.03689 mg/L 3compartmentss NA 95% Rat Human +DTXSID8035186 Css NA 0.003564 mg/L PBTK NA 50% Rat Human +DTXSID8035186 Css NA 0.02448 mg/L PBTK NA 95% Rat Human DTXSID8035217 Clint NA 7.531 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8035217 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8035217 Vd NA 0.824 L/kg 1compartment NA NA Human Human +DTXSID8035217 Vd NA 0.6851 L/kg 1compartment NA NA Human Human DTXSID8035217 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8035217 TK.Half.Life NA 0.7862 hours 1compartment NA NA Human Human -DTXSID8035217 Css NA 0.06482 mg/L 3compartmentss NA 50% Human Human -DTXSID8035217 Css NA 0.6414 mg/L 3compartmentss NA 95% Human Human -DTXSID8035217 Css NA 0.05413 mg/L PBTK NA 50% Human Human -DTXSID8035217 Css NA 0.4668 mg/L PBTK NA 95% Human Human +DTXSID8035217 TK.Half.Life NA 0.6502 hours 1compartment NA NA Human Human +DTXSID8035217 Css NA 0.0578 mg/L 3compartmentss NA 50% Human Human +DTXSID8035217 Css NA 0.6049 mg/L 3compartmentss NA 95% Human Human +DTXSID8035217 Css NA 0.04697 mg/L PBTK NA 50% Human Human +DTXSID8035217 Css NA 0.43 mg/L PBTK NA 95% Human Human DTXSID8035217 Clint NA 7.531 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8035217 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8035217 Vd NA 0.8555 L/kg 1compartment NA NA Rat Human +DTXSID8035217 Vd NA 0.738 L/kg 1compartment NA NA Rat Human DTXSID8035217 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8035217 TK.Half.Life NA 0.4178 hours 1compartment NA NA Rat Human -DTXSID8035217 Css NA 0.03057 mg/L 3compartmentss NA 50% Rat Human -DTXSID8035217 Css NA 0.2427 mg/L 3compartmentss NA 95% Rat Human -DTXSID8035217 Css NA 0.02544 mg/L PBTK NA 50% Rat Human -DTXSID8035217 Css NA 0.159 mg/L PBTK NA 95% Rat Human +DTXSID8035217 TK.Half.Life NA 0.3553 hours 1compartment NA NA Rat Human +DTXSID8035217 Css NA 0.006504 mg/L 3compartmentss NA 50% Rat Human +DTXSID8035217 Css NA 0.05063 mg/L 3compartmentss NA 95% Rat Human +DTXSID8035217 Css NA 0.005402 mg/L PBTK NA 50% Rat Human +DTXSID8035217 Css NA 0.03415 mg/L PBTK NA 95% Rat Human +DTXSID8036732 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8036732 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8036732 Vd NA 1.224 L/kg 1compartment NA NA Human Human +DTXSID8036732 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8036732 TK.Half.Life NA 26.74 hours 1compartment NA NA Human Human +DTXSID8036732 Css NA 2.262 mg/L 3compartmentss NA 50% Human Human +DTXSID8036732 Css NA 8.945 mg/L 3compartmentss NA 95% Human Human +DTXSID8036732 Css NA 1.742 mg/L PBTK NA 50% Human Human +DTXSID8036732 Css NA 5.89 mg/L PBTK NA 95% Human Human +DTXSID8036732 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8036732 Fup 0.339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8036732 Vd NA 1.034 L/kg 1compartment NA NA Rat Human +DTXSID8036732 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8036732 TK.Half.Life NA 6.959 hours 1compartment NA NA Rat Human +DTXSID8036732 Css NA 0.1441 mg/L 3compartmentss NA 50% Rat Human +DTXSID8036732 Css NA 0.4885 mg/L 3compartmentss NA 95% Rat Human +DTXSID8036732 Css NA 0.1104 mg/L PBTK NA 50% Rat Human +DTXSID8036732 Css NA 0.3094 mg/L PBTK NA 95% Rat Human +DTXSID8037128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037128 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8037128 Vd NA 4.507 L/kg 1compartment NA NA Human Human +DTXSID8037128 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8037128 TK.Half.Life NA 2.157 hours 1compartment NA NA Human Human +DTXSID8037128 Css NA 0.01324 mg/L 3compartmentss NA 50% Human Human +DTXSID8037128 Css NA 0.1831 mg/L 3compartmentss NA 95% Human Human +DTXSID8037128 Css NA 0.01944 mg/L PBTK NA 50% Human Human +DTXSID8037128 Css NA 0.1778 mg/L PBTK NA 95% Human Human +DTXSID8037128 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037128 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8037128 Vd NA 4.547 L/kg 1compartment NA NA Rat Human +DTXSID8037128 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8037128 TK.Half.Life NA 1.133 hours 1compartment NA NA Rat Human +DTXSID8037128 Css NA 0.001486 mg/L 3compartmentss NA 50% Rat Human +DTXSID8037128 Css NA 0.01771 mg/L 3compartmentss NA 95% Rat Human +DTXSID8037128 Css NA 0.002398 mg/L PBTK NA 50% Rat Human +DTXSID8037128 Css NA 0.01803 mg/L PBTK NA 95% Rat Human DTXSID8037207 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8037207 Fup NA 0.4683 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037207 Vd NA 0.6447 L/kg 1compartment NA NA Human Human +DTXSID8037207 Vd NA 0.5908 L/kg 1compartment NA NA Human Human DTXSID8037207 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8037207 TK.Half.Life NA 8.907 hours 1compartment NA NA Human Human -DTXSID8037207 Css NA 1.482 mg/L 3compartmentss NA 50% Human Human -DTXSID8037207 Css NA 7.163 mg/L 3compartmentss NA 95% Human Human -DTXSID8037207 Css NA 1.171 mg/L PBTK NA 50% Human Human -DTXSID8037207 Css NA 4.664 mg/L PBTK NA 95% Human Human +DTXSID8037207 TK.Half.Life NA 8.162 hours 1compartment NA NA Human Human +DTXSID8037207 Css NA 1.26 mg/L 3compartmentss NA 50% Human Human +DTXSID8037207 Css NA 6.426 mg/L 3compartmentss NA 95% Human Human +DTXSID8037207 Css NA 0.974 mg/L PBTK NA 50% Human Human +DTXSID8037207 Css NA 4.093 mg/L PBTK NA 95% Human Human DTXSID8037207 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8037207 Fup NA 0.4683 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037207 Vd NA 0.6555 L/kg 1compartment NA NA Rat Human +DTXSID8037207 Vd NA 0.6045 L/kg 1compartment NA NA Rat Human DTXSID8037207 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8037207 TK.Half.Life NA 3.086 hours 1compartment NA NA Rat Human -DTXSID8037207 Css NA 0.4014 mg/L 3compartmentss NA 50% Rat Human -DTXSID8037207 Css NA 1.695 mg/L 3compartmentss NA 95% Rat Human -DTXSID8037207 Css NA 0.3036 mg/L PBTK NA 50% Rat Human -DTXSID8037207 Css NA 1.024 mg/L PBTK NA 95% Rat Human +DTXSID8037207 TK.Half.Life NA 2.847 hours 1compartment NA NA Rat Human +DTXSID8037207 Css NA 0.02369 mg/L 3compartmentss NA 50% Rat Human +DTXSID8037207 Css NA 0.1615 mg/L 3compartmentss NA 95% Rat Human +DTXSID8037207 Css NA 0.0176 mg/L PBTK NA 50% Rat Human +DTXSID8037207 Css NA 0.1044 mg/L PBTK NA 95% Rat Human DTXSID8037594 Clint 6.53 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8037594 Fup 0.0461 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8037594 Vd NA 1.51 L/kg 1compartment NA NA Human Human DTXSID8037594 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID8037594 TK.Half.Life NA 21.04 hours 1compartment NA NA Human Human -DTXSID8037594 Css NA 1.727 mg/L 3compartmentss NA 50% Human Human -DTXSID8037594 Css NA 11.07 mg/L 3compartmentss NA 95% Human Human -DTXSID8037594 Css NA 1.119 mg/L PBTK NA 50% Human Human -DTXSID8037594 Css NA 6.885 mg/L PBTK NA 95% Human Human +DTXSID8037594 Css NA 1.662 mg/L 3compartmentss NA 50% Human Human +DTXSID8037594 Css NA 10.67 mg/L 3compartmentss NA 95% Human Human +DTXSID8037594 Css NA 1.087 mg/L PBTK NA 50% Human Human +DTXSID8037594 Css NA 6.681 mg/L PBTK NA 95% Human Human DTXSID8037594 Clint 6.53 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8037594 Fup 0.0461 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8037594 Vd NA 1.133 L/kg 1compartment NA NA Rat Human DTXSID8037594 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID8037594 TK.Half.Life NA 7.904 hours 1compartment NA NA Rat Human -DTXSID8037594 Css NA 0.9286 mg/L 3compartmentss NA 50% Rat Human -DTXSID8037594 Css NA 4.229 mg/L 3compartmentss NA 95% Rat Human -DTXSID8037594 Css NA 0.5719 mg/L PBTK NA 50% Rat Human -DTXSID8037594 Css NA 2.448 mg/L PBTK NA 95% Rat Human -DTXSID8037596 Clint NA 9.584 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037596 Fup NA 0.1769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037596 Vd NA 2.022 L/kg 1compartment NA NA Human Human +DTXSID8037594 Css NA 0.2091 mg/L 3compartmentss NA 50% Rat Human +DTXSID8037594 Css NA 0.9804 mg/L 3compartmentss NA 95% Rat Human +DTXSID8037594 Css NA 0.133 mg/L PBTK NA 50% Rat Human +DTXSID8037594 Css NA 0.5929 mg/L PBTK NA 95% Rat Human +DTXSID8037596 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037596 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037596 Vd NA 1.811 L/kg 1compartment NA NA Human Human DTXSID8037596 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8037596 TK.Half.Life NA 8.065 hours 1compartment NA NA Human Human -DTXSID8037596 Css NA 0.4144 mg/L 3compartmentss NA 50% Human Human -DTXSID8037596 Css NA 2.297 mg/L 3compartmentss NA 95% Human Human -DTXSID8037596 Css NA 0.2955 mg/L PBTK NA 50% Human Human -DTXSID8037596 Css NA 1.555 mg/L PBTK NA 95% Human Human -DTXSID8037596 Clint NA 9.584 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037596 Fup NA 0.1769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037596 Vd NA 1.554 L/kg 1compartment NA NA Rat Human +DTXSID8037596 TK.Half.Life NA 4.606 hours 1compartment NA NA Human Human +DTXSID8037596 Css NA 0.2456 mg/L 3compartmentss NA 50% Human Human +DTXSID8037596 Css NA 1.767 mg/L 3compartmentss NA 95% Human Human +DTXSID8037596 Css NA 0.1688 mg/L PBTK NA 50% Human Human +DTXSID8037596 Css NA 1.142 mg/L PBTK NA 95% Human Human +DTXSID8037596 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037596 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037596 Vd NA 1.388 L/kg 1compartment NA NA Rat Human DTXSID8037596 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8037596 TK.Half.Life NA 2.672 hours 1compartment NA NA Rat Human -DTXSID8037596 Css NA 0.2148 mg/L 3compartmentss NA 50% Rat Human -DTXSID8037596 Css NA 0.9318 mg/L 3compartmentss NA 95% Rat Human -DTXSID8037596 Css NA 0.1475 mg/L PBTK NA 50% Rat Human -DTXSID8037596 Css NA 0.595 mg/L PBTK NA 95% Rat Human -DTXSID8037706 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8037706 Fup 0.00363 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8037706 Vd NA 0.3428 L/kg 1compartment NA NA Human Human -DTXSID8037706 Days.Css NA 170 Days PBTK NA NA Human Human -DTXSID8037706 TK.Half.Life NA 617.8 hours 1compartment NA NA Human Human -DTXSID8037706 Css NA 314.5 mg/L 3compartmentss NA 50% Human Human -DTXSID8037706 Css NA 1430 mg/L 3compartmentss NA 95% Human Human -DTXSID8037706 Css NA 186.7 mg/L PBTK NA 50% Human Human -DTXSID8037706 Css NA 822.7 mg/L PBTK NA 95% Human Human -DTXSID8037706 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8037706 Fup 0.00363 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8037706 Vd NA 0.2949 L/kg 1compartment NA NA Rat Human -DTXSID8037706 Days.Css NA 45 Days PBTK NA NA Rat Human -DTXSID8037706 TK.Half.Life NA 179.6 hours 1compartment NA NA Rat Human -DTXSID8037706 Css NA 88.89 mg/L 3compartmentss NA 50% Rat Human -DTXSID8037706 Css NA 350.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID8037706 Css NA 49.25 mg/L PBTK NA 50% Rat Human -DTXSID8037706 Css NA 190.3 mg/L PBTK NA 95% Rat Human -DTXSID8037708 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8037708 Fup 0.00363 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8037708 Vd NA 0.1791 L/kg 1compartment NA NA Human Human -DTXSID8037708 Days.Css NA 90 Days PBTK NA NA Human Human -DTXSID8037708 TK.Half.Life NA 319.3 hours 1compartment NA NA Human Human -DTXSID8037708 Css NA 317.8 mg/L 3compartmentss NA 50% Human Human -DTXSID8037708 Css NA 1432 mg/L 3compartmentss NA 95% Human Human -DTXSID8037708 Css NA 185 mg/L PBTK NA 50% Human Human -DTXSID8037708 Css NA 819.4 mg/L PBTK NA 95% Human Human -DTXSID8037708 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8037708 Fup 0.00363 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8037708 Vd NA 0.1755 L/kg 1compartment NA NA Rat Human -DTXSID8037708 Days.Css NA 25 Days PBTK NA NA Rat Human -DTXSID8037708 TK.Half.Life NA 106.6 hours 1compartment NA NA Rat Human -DTXSID8037708 Css NA 89.93 mg/L 3compartmentss NA 50% Rat Human -DTXSID8037708 Css NA 351.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID8037708 Css NA 48.83 mg/L PBTK NA 50% Rat Human -DTXSID8037708 Css NA 189.9 mg/L PBTK NA 95% Rat Human -DTXSID8037750 Clint NA 39.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037750 Fup NA 0.0417 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037750 Vd NA 1.101 L/kg 1compartment NA NA Human Human -DTXSID8037750 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8037750 TK.Half.Life NA 3.504 hours 1compartment NA NA Human Human -DTXSID8037750 Css NA 0.4212 mg/L 3compartmentss NA 50% Human Human -DTXSID8037750 Css NA 3.263 mg/L 3compartmentss NA 95% Human Human -DTXSID8037750 Css NA 0.263 mg/L PBTK NA 50% Human Human -DTXSID8037750 Css NA 1.976 mg/L PBTK NA 95% Human Human -DTXSID8037750 Clint NA 39.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037750 Fup NA 0.0417 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037750 Vd NA 0.832 L/kg 1compartment NA NA Rat Human -DTXSID8037750 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8037750 TK.Half.Life NA 1.469 hours 1compartment NA NA Rat Human -DTXSID8037750 Css NA 0.2392 mg/L 3compartmentss NA 50% Rat Human -DTXSID8037750 Css NA 1.538 mg/L 3compartmentss NA 95% Rat Human -DTXSID8037750 Css NA 0.1399 mg/L PBTK NA 50% Rat Human -DTXSID8037750 Css NA 0.8684 mg/L PBTK NA 95% Rat Human -DTXSID8037752 Clint NA 33.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037752 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037752 Vd NA 1.582 L/kg 1compartment NA NA Human Human -DTXSID8037752 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8037752 TK.Half.Life NA 11.27 hours 1compartment NA NA Human Human -DTXSID8037752 Css NA 1.084 mg/L 3compartmentss NA 50% Human Human -DTXSID8037752 Css NA 10.01 mg/L 3compartmentss NA 95% Human Human -DTXSID8037752 Css NA 0.6804 mg/L PBTK NA 50% Human Human -DTXSID8037752 Css NA 6.054 mg/L PBTK NA 95% Human Human -DTXSID8037752 Clint NA 33.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037752 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037752 Vd NA 1.172 L/kg 1compartment NA NA Rat Human -DTXSID8037752 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8037752 TK.Half.Life NA 4.224 hours 1compartment NA NA Rat Human -DTXSID8037752 Css NA 0.6133 mg/L 3compartmentss NA 50% Rat Human -DTXSID8037752 Css NA 4.331 mg/L 3compartmentss NA 95% Rat Human -DTXSID8037752 Css NA 0.3602 mg/L PBTK NA 50% Rat Human -DTXSID8037752 Css NA 2.472 mg/L PBTK NA 95% Rat Human +DTXSID8037596 TK.Half.Life NA 1.646 hours 1compartment NA NA Rat Human +DTXSID8037596 Css NA 0.03198 mg/L 3compartmentss NA 50% Rat Human +DTXSID8037596 Css NA 0.1775 mg/L 3compartmentss NA 95% Rat Human +DTXSID8037596 Css NA 0.0216 mg/L PBTK NA 50% Rat Human +DTXSID8037596 Css NA 0.1136 mg/L PBTK NA 95% Rat Human +DTXSID8037750 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037750 Fup 0.0271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037750 Vd NA 2.985 L/kg 1compartment NA NA Human Human +DTXSID8037750 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID8037750 TK.Half.Life NA 52.83 hours 1compartment NA NA Human Human +DTXSID8037750 Css NA 2.188 mg/L 3compartmentss NA 50% Human Human +DTXSID8037750 Css NA 14.91 mg/L 3compartmentss NA 95% Human Human +DTXSID8037750 Css NA 1.503 mg/L PBTK NA 50% Human Human +DTXSID8037750 Css NA 9.854 mg/L PBTK NA 95% Human Human +DTXSID8037750 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037750 Fup 0.0271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037750 Vd NA 2.236 L/kg 1compartment NA NA Rat Human +DTXSID8037750 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID8037750 TK.Half.Life NA 8.596 hours 1compartment NA NA Rat Human +DTXSID8037750 Css NA 0.2812 mg/L 3compartmentss NA 50% Rat Human +DTXSID8037750 Css NA 1.597 mg/L 3compartmentss NA 95% Rat Human +DTXSID8037750 Css NA 0.1913 mg/L PBTK NA 50% Rat Human +DTXSID8037750 Css NA 1.063 mg/L PBTK NA 95% Rat Human +DTXSID8037752 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037752 Fup 0.00279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037752 Vd NA 1.084 L/kg 1compartment NA NA Human Human +DTXSID8037752 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID8037752 TK.Half.Life NA 39.36 hours 1compartment NA NA Human Human +DTXSID8037752 Css NA 5.984 mg/L 3compartmentss NA 50% Human Human +DTXSID8037752 Css NA 51.61 mg/L 3compartmentss NA 95% Human Human +DTXSID8037752 Css NA 3.621 mg/L PBTK NA 50% Human Human +DTXSID8037752 Css NA 30.5 mg/L PBTK NA 95% Human Human +DTXSID8037752 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037752 Fup 0.00279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037752 Vd NA 0.7925 L/kg 1compartment NA NA Rat Human +DTXSID8037752 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8037752 TK.Half.Life NA 17.04 hours 1compartment NA NA Rat Human +DTXSID8037752 Css NA 0.7897 mg/L 3compartmentss NA 50% Rat Human +DTXSID8037752 Css NA 5.507 mg/L 3compartmentss NA 95% Rat Human +DTXSID8037752 Css NA 0.4614 mg/L PBTK NA 50% Rat Human +DTXSID8037752 Css NA 3.136 mg/L PBTK NA 95% Rat Human DTXSID8037754 Clint 9.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8037754 Fup NA 0.1916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037754 Vd NA 1.31 L/kg 1compartment NA NA Human Human -DTXSID8037754 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8037754 TK.Half.Life NA 3.968 hours 1compartment NA NA Human Human -DTXSID8037754 Css NA 0.2881 mg/L 3compartmentss NA 50% Human Human -DTXSID8037754 Css NA 1.715 mg/L 3compartmentss NA 95% Human Human -DTXSID8037754 Css NA 0.2048 mg/L PBTK NA 50% Human Human -DTXSID8037754 Css NA 1.127 mg/L PBTK NA 95% Human Human +DTXSID8037754 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037754 Vd NA 2.738 L/kg 1compartment NA NA Human Human +DTXSID8037754 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8037754 TK.Half.Life NA 20.07 hours 1compartment NA NA Human Human +DTXSID8037754 Css NA 0.7851 mg/L 3compartmentss NA 50% Human Human +DTXSID8037754 Css NA 4.481 mg/L 3compartmentss NA 95% Human Human +DTXSID8037754 Css NA 0.5636 mg/L PBTK NA 50% Human Human +DTXSID8037754 Css NA 3.114 mg/L PBTK NA 95% Human Human DTXSID8037754 Clint 9.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8037754 Fup NA 0.1916 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037754 Vd NA 1.044 L/kg 1compartment NA NA Rat Human -DTXSID8037754 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8037754 TK.Half.Life NA 1.663 hours 1compartment NA NA Rat Human -DTXSID8037754 Css NA 0.1513 mg/L 3compartmentss NA 50% Rat Human -DTXSID8037754 Css NA 0.6792 mg/L 3compartmentss NA 95% Rat Human -DTXSID8037754 Css NA 0.1028 mg/L PBTK NA 50% Rat Human -DTXSID8037754 Css NA 0.4304 mg/L PBTK NA 95% Rat Human -DTXSID8037756 Clint NA 6.239 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037756 Fup NA 0.3839 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8037756 Vd NA 1.769 L/kg 1compartment NA NA Human Human +DTXSID8037754 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037754 Vd NA 2.073 L/kg 1compartment NA NA Rat Human +DTXSID8037754 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8037754 TK.Half.Life NA 4.357 hours 1compartment NA NA Rat Human +DTXSID8037754 Css NA 0.09657 mg/L 3compartmentss NA 50% Rat Human +DTXSID8037754 Css NA 0.4082 mg/L 3compartmentss NA 95% Rat Human +DTXSID8037754 Css NA 0.06868 mg/L PBTK NA 50% Rat Human +DTXSID8037754 Css NA 0.28 mg/L PBTK NA 95% Rat Human +DTXSID8037756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037756 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8037756 Vd NA 1.538 L/kg 1compartment NA NA Human Human DTXSID8037756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8037756 TK.Half.Life NA 4.415 hours 1compartment NA NA Human Human -DTXSID8037756 Css NA 0.2131 mg/L 3compartmentss NA 50% Human Human -DTXSID8037756 Css NA 1.273 mg/L 3compartmentss NA 95% Human Human -DTXSID8037756 Css NA 0.1701 mg/L PBTK NA 50% Human Human -DTXSID8037756 Css NA 0.9222 mg/L PBTK NA 95% Human Human -DTXSID8037756 Clint NA 6.239 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037756 Fup NA 0.3839 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8037756 Vd NA 1.44 L/kg 1compartment NA NA Rat Human +DTXSID8037756 TK.Half.Life NA 2.253 hours 1compartment NA NA Human Human +DTXSID8037756 Css NA 0.08696 mg/L 3compartmentss NA 50% Human Human +DTXSID8037756 Css NA 0.6059 mg/L 3compartmentss NA 95% Human Human +DTXSID8037756 Css NA 0.06486 mg/L PBTK NA 50% Human Human +DTXSID8037756 Css NA 0.4231 mg/L PBTK NA 95% Human Human +DTXSID8037756 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037756 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8037756 Vd NA 1.242 L/kg 1compartment NA NA Rat Human DTXSID8037756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8037756 TK.Half.Life NA 1.703 hours 1compartment NA NA Rat Human -DTXSID8037756 Css NA 0.1082 mg/L 3compartmentss NA 50% Rat Human -DTXSID8037756 Css NA 0.4768 mg/L 3compartmentss NA 95% Rat Human -DTXSID8037756 Css NA 0.08364 mg/L PBTK NA 50% Rat Human -DTXSID8037756 Css NA 0.3206 mg/L PBTK NA 95% Rat Human +DTXSID8037756 TK.Half.Life NA 0.8937 hours 1compartment NA NA Rat Human +DTXSID8037756 Css NA 0.01097 mg/L 3compartmentss NA 50% Rat Human +DTXSID8037756 Css NA 0.05858 mg/L 3compartmentss NA 95% Rat Human +DTXSID8037756 Css NA 0.008213 mg/L PBTK NA 50% Rat Human +DTXSID8037756 Css NA 0.04113 mg/L PBTK NA 95% Rat Human +DTXSID80379721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80379721 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80379721 Vd NA 2.545 L/kg 1compartment NA NA Human Human +DTXSID80379721 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID80379721 TK.Half.Life NA 17.29 hours 1compartment NA NA Human Human +DTXSID80379721 Css NA 0.8634 mg/L 3compartmentss NA 50% Human Human +DTXSID80379721 Css NA 5.625 mg/L 3compartmentss NA 95% Human Human +DTXSID80379721 Css NA 0.5836 mg/L PBTK NA 50% Human Human +DTXSID80379721 Css NA 3.64 mg/L PBTK NA 95% Human Human +DTXSID80379721 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80379721 Fup 0.0544 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80379721 Vd NA 1.908 L/kg 1compartment NA NA Rat Human +DTXSID80379721 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80379721 TK.Half.Life NA 4.247 hours 1compartment NA NA Rat Human +DTXSID80379721 Css NA 0.1119 mg/L 3compartmentss NA 50% Rat Human +DTXSID80379721 Css NA 0.6147 mg/L 3compartmentss NA 95% Rat Human +DTXSID80379721 Css NA 0.07421 mg/L PBTK NA 50% Rat Human +DTXSID80379721 Css NA 0.3964 mg/L PBTK NA 95% Rat Human DTXSID8038770 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8038770 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8038770 Vd NA 0.3755 L/kg 1compartment NA NA Human Human +DTXSID8038770 Vd NA 0.3234 L/kg 1compartment NA NA Human Human DTXSID8038770 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8038770 TK.Half.Life NA 7.52 hours 1compartment NA NA Human Human -DTXSID8038770 Css NA 2.375 mg/L 3compartmentss NA 50% Human Human -DTXSID8038770 Css NA 9.805 mg/L 3compartmentss NA 95% Human Human -DTXSID8038770 Css NA 1.629 mg/L PBTK NA 50% Human Human -DTXSID8038770 Css NA 6.145 mg/L PBTK NA 95% Human Human +DTXSID8038770 TK.Half.Life NA 6.472 hours 1compartment NA NA Human Human +DTXSID8038770 Css NA 2.061 mg/L 3compartmentss NA 50% Human Human +DTXSID8038770 Css NA 8.595 mg/L 3compartmentss NA 95% Human Human +DTXSID8038770 Css NA 1.383 mg/L PBTK NA 50% Human Human +DTXSID8038770 Css NA 5.276 mg/L PBTK NA 95% Human Human DTXSID8038770 Clint NA 9.794e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8038770 Fup NA 0.323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8038770 Vd NA 0.3863 L/kg 1compartment NA NA Rat Human +DTXSID8038770 Vd NA 0.3419 L/kg 1compartment NA NA Rat Human DTXSID8038770 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8038770 TK.Half.Life NA 2.636 hours 1compartment NA NA Rat Human -DTXSID8038770 Css NA 0.6596 mg/L 3compartmentss NA 50% Rat Human -DTXSID8038770 Css NA 2.281 mg/L 3compartmentss NA 95% Rat Human -DTXSID8038770 Css NA 0.4286 mg/L PBTK NA 50% Rat Human -DTXSID8038770 Css NA 1.313 mg/L PBTK NA 95% Rat Human -DTXSID8038801 Clint NA 8.507 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8038801 Fup NA 0.0843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8038801 Vd NA 1.693 L/kg 1compartment NA NA Human Human -DTXSID8038801 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8038801 TK.Half.Life NA 11.99 hours 1compartment NA NA Human Human -DTXSID8038801 Css NA 0.9852 mg/L 3compartmentss NA 50% Human Human -DTXSID8038801 Css NA 6.501 mg/L 3compartmentss NA 95% Human Human -DTXSID8038801 Css NA 0.6499 mg/L PBTK NA 50% Human Human -DTXSID8038801 Css NA 4.02 mg/L PBTK NA 95% Human Human -DTXSID8038801 Clint NA 8.507 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8038801 Fup NA 0.0843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8038801 Vd NA 1.284 L/kg 1compartment NA NA Rat Human +DTXSID8038770 TK.Half.Life NA 2.332 hours 1compartment NA NA Rat Human +DTXSID8038770 Css NA 0.03861 mg/L 3compartmentss NA 50% Rat Human +DTXSID8038770 Css NA 0.2276 mg/L 3compartmentss NA 95% Rat Human +DTXSID8038770 Css NA 0.02474 mg/L PBTK NA 50% Rat Human +DTXSID8038770 Css NA 0.1369 mg/L PBTK NA 95% Rat Human +DTXSID8038801 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8038801 Fup 0.066 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8038801 Vd NA 1.525 L/kg 1compartment NA NA Human Human +DTXSID8038801 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8038801 TK.Half.Life NA 16.34 hours 1compartment NA NA Human Human +DTXSID8038801 Css NA 1.565 mg/L 3compartmentss NA 50% Human Human +DTXSID8038801 Css NA 10.07 mg/L 3compartmentss NA 95% Human Human +DTXSID8038801 Css NA 1.016 mg/L PBTK NA 50% Human Human +DTXSID8038801 Css NA 6.252 mg/L PBTK NA 95% Human Human +DTXSID8038801 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8038801 Fup 0.066 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8038801 Vd NA 1.154 L/kg 1compartment NA NA Rat Human DTXSID8038801 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8038801 TK.Half.Life NA 4.343 hours 1compartment NA NA Rat Human -DTXSID8038801 Css NA 0.5308 mg/L 3compartmentss NA 50% Rat Human -DTXSID8038801 Css NA 2.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID8038801 Css NA 0.3318 mg/L PBTK NA 50% Rat Human -DTXSID8038801 Css NA 1.552 mg/L PBTK NA 95% Rat Human -DTXSID8038857 Clint NA 12.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8038857 Fup NA 0.1115 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8038857 Vd NA 2.565 L/kg 1compartment NA NA Human Human -DTXSID8038857 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8038857 TK.Half.Life NA 17.05 hours 1compartment NA NA Human Human -DTXSID8038857 Css NA 0.81 mg/L 3compartmentss NA 50% Human Human -DTXSID8038857 Css NA 4.947 mg/L 3compartmentss NA 95% Human Human -DTXSID8038857 Css NA 0.5639 mg/L PBTK NA 50% Human Human -DTXSID8038857 Css NA 3.324 mg/L PBTK NA 95% Human Human -DTXSID8038857 Clint NA 12.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8038857 Fup NA 0.1115 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8038857 Vd NA 1.935 L/kg 1compartment NA NA Rat Human +DTXSID8038801 TK.Half.Life NA 6.145 hours 1compartment NA NA Rat Human +DTXSID8038801 Css NA 0.1955 mg/L 3compartmentss NA 50% Rat Human +DTXSID8038801 Css NA 0.9403 mg/L 3compartmentss NA 95% Rat Human +DTXSID8038801 Css NA 0.1235 mg/L PBTK NA 50% Rat Human +DTXSID8038801 Css NA 0.5666 mg/L PBTK NA 95% Rat Human +DTXSID8038855 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8038855 Fup 0.0803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8038855 Vd NA 2.353 L/kg 1compartment NA NA Human Human +DTXSID8038855 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8038855 TK.Half.Life NA 10.92 hours 1compartment NA NA Human Human +DTXSID8038855 Css NA 0.54 mg/L 3compartmentss NA 50% Human Human +DTXSID8038855 Css NA 3.688 mg/L 3compartmentss NA 95% Human Human +DTXSID8038855 Css NA 0.366 mg/L PBTK NA 50% Human Human +DTXSID8038855 Css NA 2.367 mg/L PBTK NA 95% Human Human +DTXSID8038855 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8038855 Fup 0.0803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8038855 Vd NA 1.771 L/kg 1compartment NA NA Rat Human +DTXSID8038855 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8038855 TK.Half.Life NA 3.075 hours 1compartment NA NA Rat Human +DTXSID8038855 Css NA 0.06987 mg/L 3compartmentss NA 50% Rat Human +DTXSID8038855 Css NA 0.371 mg/L 3compartmentss NA 95% Rat Human +DTXSID8038855 Css NA 0.04668 mg/L PBTK NA 50% Rat Human +DTXSID8038855 Css NA 0.2348 mg/L PBTK NA 95% Rat Human +DTXSID8038857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8038857 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8038857 Vd NA 2.532 L/kg 1compartment NA NA Human Human +DTXSID8038857 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8038857 TK.Half.Life NA 6.454 hours 1compartment NA NA Human Human +DTXSID8038857 Css NA 0.2133 mg/L 3compartmentss NA 50% Human Human +DTXSID8038857 Css NA 1.313 mg/L 3compartmentss NA 95% Human Human +DTXSID8038857 Css NA 0.1571 mg/L PBTK NA 50% Human Human +DTXSID8038857 Css NA 0.9073 mg/L PBTK NA 95% Human Human +DTXSID8038857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8038857 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8038857 Vd NA 1.932 L/kg 1compartment NA NA Rat Human DTXSID8038857 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8038857 TK.Half.Life NA 4.186 hours 1compartment NA NA Rat Human -DTXSID8038857 Css NA 0.44 mg/L 3compartmentss NA 50% Rat Human -DTXSID8038857 Css NA 2.101 mg/L 3compartmentss NA 95% Rat Human -DTXSID8038857 Css NA 0.2912 mg/L PBTK NA 50% Rat Human -DTXSID8038857 Css NA 1.321 mg/L PBTK NA 95% Rat Human -DTXSID8039241 Clint NA 4.856 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8039241 Fup NA 0.8193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8039241 Vd NA 1.592 L/kg 1compartment NA NA Human Human +DTXSID8038857 TK.Half.Life NA 1.774 hours 1compartment NA NA Rat Human +DTXSID8038857 Css NA 0.02653 mg/L 3compartmentss NA 50% Rat Human +DTXSID8038857 Css NA 0.1352 mg/L 3compartmentss NA 95% Rat Human +DTXSID8038857 Css NA 0.0193 mg/L PBTK NA 50% Rat Human +DTXSID8038857 Css NA 0.09221 mg/L PBTK NA 95% Rat Human +DTXSID8039241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8039241 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8039241 Vd NA 0.934 L/kg 1compartment NA NA Human Human DTXSID8039241 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8039241 TK.Half.Life NA 2.275 hours 1compartment NA NA Human Human -DTXSID8039241 Css NA 0.11 mg/L 3compartmentss NA 50% Human Human -DTXSID8039241 Css NA 0.8849 mg/L 3compartmentss NA 95% Human Human -DTXSID8039241 Css NA 0.1005 mg/L PBTK NA 50% Human Human -DTXSID8039241 Css NA 0.6405 mg/L PBTK NA 95% Human Human -DTXSID8039241 Clint NA 4.856 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8039241 Fup NA 0.8193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8039241 Vd NA 1.407 L/kg 1compartment NA NA Rat Human +DTXSID8039241 TK.Half.Life NA 1.182 hours 1compartment NA NA Human Human +DTXSID8039241 Css NA 0.06406 mg/L 3compartmentss NA 50% Human Human +DTXSID8039241 Css NA 0.4845 mg/L 3compartmentss NA 95% Human Human +DTXSID8039241 Css NA 0.04758 mg/L PBTK NA 50% Human Human +DTXSID8039241 Css NA 0.3298 mg/L PBTK NA 95% Human Human +DTXSID8039241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8039241 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8039241 Vd NA 0.8172 L/kg 1compartment NA NA Rat Human DTXSID8039241 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8039241 TK.Half.Life NA 0.9946 hours 1compartment NA NA Rat Human -DTXSID8039241 Css NA 0.05107 mg/L 3compartmentss NA 50% Rat Human -DTXSID8039241 Css NA 0.3763 mg/L 3compartmentss NA 95% Rat Human -DTXSID8039241 Css NA 0.04634 mg/L PBTK NA 50% Rat Human -DTXSID8039241 Css NA 0.2433 mg/L PBTK NA 95% Rat Human +DTXSID8039241 TK.Half.Life NA 0.5365 hours 1compartment NA NA Rat Human +DTXSID8039241 Css NA 0.007912 mg/L 3compartmentss NA 50% Rat Human +DTXSID8039241 Css NA 0.04466 mg/L 3compartmentss NA 95% Rat Human +DTXSID8039241 Css NA 0.005912 mg/L PBTK NA 50% Rat Human +DTXSID8039241 Css NA 0.03009 mg/L PBTK NA 95% Rat Human DTXSID8040147 Clint 23.48 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.31.5.580 NA Human Human DTXSID8040147 Fup 0.22 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID8040147 Vd NA 1.773 L/kg 1compartment NA NA Human Human +DTXSID8040147 Vd NA 2.596 L/kg 1compartment NA NA Human Human DTXSID8040147 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8040147 TK.Half.Life NA 2.692 hours 1compartment NA NA Human Human -DTXSID8040147 Css NA 0.1048 mg/L 3compartmentss NA 50% Human Human -DTXSID8040147 Css NA 0.7015 mg/L 3compartmentss NA 95% Human Human -DTXSID8040147 Css NA 0.08814 mg/L PBTK NA 50% Human Human -DTXSID8040147 Css NA 0.5324 mg/L PBTK NA 95% Human Human +DTXSID8040147 TK.Half.Life NA 6.25 hours 1compartment NA NA Human Human +DTXSID8040147 Css NA 0.159 mg/L 3compartmentss NA 50% Human Human +DTXSID8040147 Css NA 0.9781 mg/L 3compartmentss NA 95% Human Human +DTXSID8040147 Css NA 0.1588 mg/L PBTK NA 50% Human Human +DTXSID8040147 Css NA 0.9772 mg/L PBTK NA 95% Human Human DTXSID8040147 Clint 687.5 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat DTXSID8040147 Fup 0.184 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat -DTXSID8040147 Vd NA 1.274 L/kg 1compartment NA NA Rat Rat +DTXSID8040147 Vd NA 1.899 L/kg 1compartment NA NA Rat Rat DTXSID8040147 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8040147 TK.Half.Life NA 0.3544 hours 1compartment NA NA Rat Rat -DTXSID8040147 Css NA 0.002226 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8040147 Css NA 0.01316 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8040147 Css NA 0.001868 mg/L PBTK NA 50% Rat Rat -DTXSID8040147 Css NA 0.0101 mg/L PBTK NA 95% Rat Rat +DTXSID8040147 TK.Half.Life NA 0.5361 hours 1compartment NA NA Rat Rat +DTXSID8040147 Css NA 0.0006121 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8040147 Css NA 0.003822 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8040147 Css NA 0.0006384 mg/L PBTK NA 50% Rat Rat +DTXSID8040147 Css NA 0.003963 mg/L PBTK NA 95% Rat Rat DTXSID8040222 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID8040222 Fup 0.00376 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID8040222 Vd NA 0.2109 L/kg 1compartment NA NA Human Human -DTXSID8040222 Days.Css NA 92 Days PBTK NA NA Human Human -DTXSID8040222 TK.Half.Life NA 363.9 hours 1compartment NA NA Human Human -DTXSID8040222 Css NA 306.8 mg/L 3compartmentss NA 50% Human Human -DTXSID8040222 Css NA 1414 mg/L 3compartmentss NA 95% Human Human -DTXSID8040222 Css NA 178.5 mg/L PBTK NA 50% Human Human -DTXSID8040222 Css NA 815.7 mg/L PBTK NA 95% Human Human +DTXSID8040222 Vd NA 0.1655 L/kg 1compartment NA NA Human Human +DTXSID8040222 Days.Css NA 70 Days PBTK NA NA Human Human +DTXSID8040222 TK.Half.Life NA 284.8 hours 1compartment NA NA Human Human +DTXSID8040222 Css NA 283 mg/L 3compartmentss NA 50% Human Human +DTXSID8040222 Css NA 1322 mg/L 3compartmentss NA 95% Human Human +DTXSID8040222 Css NA 165 mg/L PBTK NA 50% Human Human +DTXSID8040222 Css NA 781.7 mg/L PBTK NA 95% Human Human DTXSID8040222 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID8040222 Fup 0.00376 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID8040222 Vd NA 0.1896 L/kg 1compartment NA NA Rat Human -DTXSID8040222 Days.Css NA 24 Days PBTK NA NA Rat Human -DTXSID8040222 TK.Half.Life NA 111.3 hours 1compartment NA NA Rat Human -DTXSID8040222 Css NA 87.18 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040222 Css NA 338.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040222 Css NA 47.27 mg/L PBTK NA 50% Rat Human -DTXSID8040222 Css NA 183.1 mg/L PBTK NA 95% Rat Human -DTXSID8040270 Clint NA 5.075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040270 Fup NA 0.0809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040270 Vd NA 1.523 L/kg 1compartment NA NA Human Human +DTXSID8040222 Vd NA 0.1636 L/kg 1compartment NA NA Rat Human +DTXSID8040222 Days.Css NA 20 Days PBTK NA NA Rat Human +DTXSID8040222 TK.Half.Life NA 95.94 hours 1compartment NA NA Rat Human +DTXSID8040222 Css NA 14.24 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040222 Css NA 62.38 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040222 Css NA 7.934 mg/L PBTK NA 50% Rat Human +DTXSID8040222 Css NA 34.81 mg/L PBTK NA 95% Rat Human +DTXSID8040270 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040270 Fup 0.0893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040270 Vd NA 1.591 L/kg 1compartment NA NA Human Human DTXSID8040270 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8040270 TK.Half.Life NA 16.32 hours 1compartment NA NA Human Human -DTXSID8040270 Css NA 1.578 mg/L 3compartmentss NA 50% Human Human -DTXSID8040270 Css NA 9.489 mg/L 3compartmentss NA 95% Human Human -DTXSID8040270 Css NA 1.038 mg/L PBTK NA 50% Human Human -DTXSID8040270 Css NA 5.921 mg/L PBTK NA 95% Human Human -DTXSID8040270 Clint NA 5.075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040270 Fup NA 0.0809 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040270 Vd NA 1.158 L/kg 1compartment NA NA Rat Human +DTXSID8040270 TK.Half.Life NA 13.42 hours 1compartment NA NA Human Human +DTXSID8040270 Css NA 1.157 mg/L 3compartmentss NA 50% Human Human +DTXSID8040270 Css NA 7.469 mg/L 3compartmentss NA 95% Human Human +DTXSID8040270 Css NA 0.766 mg/L PBTK NA 50% Human Human +DTXSID8040270 Css NA 4.553 mg/L PBTK NA 95% Human Human +DTXSID8040270 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040270 Fup 0.0893 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040270 Vd NA 1.211 L/kg 1compartment NA NA Rat Human DTXSID8040270 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8040270 TK.Half.Life NA 6.096 hours 1compartment NA NA Rat Human -DTXSID8040270 Css NA 0.8228 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040270 Css NA 3.667 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040270 Css NA 0.5068 mg/L PBTK NA 50% Rat Human -DTXSID8040270 Css NA 2.132 mg/L PBTK NA 95% Rat Human -DTXSID8040274 Clint NA 46.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040274 Fup NA 0.0121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040274 Vd NA 2.982 L/kg 1compartment NA NA Human Human -DTXSID8040274 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8040274 TK.Half.Life NA 33.6 hours 1compartment NA NA Human Human -DTXSID8040274 Css NA 1.399 mg/L 3compartmentss NA 50% Human Human -DTXSID8040274 Css NA 9.01 mg/L 3compartmentss NA 95% Human Human -DTXSID8040274 Css NA 0.9524 mg/L PBTK NA 50% Human Human -DTXSID8040274 Css NA 5.965 mg/L PBTK NA 95% Human Human -DTXSID8040274 Clint NA 46.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040274 Fup NA 0.0121 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040274 Vd NA 2.232 L/kg 1compartment NA NA Rat Human -DTXSID8040274 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8040274 TK.Half.Life NA 5.64 hours 1compartment NA NA Rat Human -DTXSID8040274 Css NA 0.7897 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040274 Css NA 4.231 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040274 Css NA 0.5156 mg/L PBTK NA 50% Rat Human -DTXSID8040274 Css NA 2.625 mg/L PBTK NA 95% Rat Human +DTXSID8040270 TK.Half.Life NA 4.976 hours 1compartment NA NA Rat Human +DTXSID8040270 Css NA 0.142 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040270 Css NA 0.6765 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040270 Css NA 0.09214 mg/L PBTK NA 50% Rat Human +DTXSID8040270 Css NA 0.4086 mg/L PBTK NA 95% Rat Human +DTXSID8040274 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040274 Fup 0.01 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040274 Vd NA 2.952 L/kg 1compartment NA NA Human Human +DTXSID8040274 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID8040274 TK.Half.Life NA 68.76 hours 1compartment NA NA Human Human +DTXSID8040274 Css NA 2.951 mg/L 3compartmentss NA 50% Human Human +DTXSID8040274 Css NA 19.53 mg/L 3compartmentss NA 95% Human Human +DTXSID8040274 Css NA 2.009 mg/L PBTK NA 50% Human Human +DTXSID8040274 Css NA 12.91 mg/L PBTK NA 95% Human Human +DTXSID8040274 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040274 Fup 0.01 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040274 Vd NA 2.207 L/kg 1compartment NA NA Rat Human +DTXSID8040274 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID8040274 TK.Half.Life NA 11.46 hours 1compartment NA NA Rat Human +DTXSID8040274 Css NA 0.3835 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040274 Css NA 2.25 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040274 Css NA 0.2582 mg/L PBTK NA 50% Rat Human +DTXSID8040274 Css NA 1.464 mg/L PBTK NA 95% Rat Human DTXSID8040278 Clint NA 61.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8040278 Fup NA 0.0106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8040278 Vd NA 3.059 L/kg 1compartment NA NA Human Human DTXSID8040278 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID8040278 TK.Half.Life NA 30.75 hours 1compartment NA NA Human Human -DTXSID8040278 Css NA 1.194 mg/L 3compartmentss NA 50% Human Human -DTXSID8040278 Css NA 7.377 mg/L 3compartmentss NA 95% Human Human -DTXSID8040278 Css NA 0.8249 mg/L PBTK NA 50% Human Human -DTXSID8040278 Css NA 4.886 mg/L PBTK NA 95% Human Human +DTXSID8040278 Css NA 1.166 mg/L 3compartmentss NA 50% Human Human +DTXSID8040278 Css NA 7.563 mg/L 3compartmentss NA 95% Human Human +DTXSID8040278 Css NA 0.7998 mg/L PBTK NA 50% Human Human +DTXSID8040278 Css NA 5.086 mg/L PBTK NA 95% Human Human DTXSID8040278 Clint NA 61.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8040278 Fup NA 0.0106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8040278 Vd NA 2.29 L/kg 1compartment NA NA Rat Human DTXSID8040278 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID8040278 TK.Half.Life NA 4.794 hours 1compartment NA NA Rat Human -DTXSID8040278 Css NA 0.6699 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040278 Css NA 3.505 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040278 Css NA 0.4405 mg/L PBTK NA 50% Rat Human -DTXSID8040278 Css NA 2.224 mg/L PBTK NA 95% Rat Human -DTXSID8040436 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040436 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040436 Vd NA 0.2802 L/kg 1compartment NA NA Human Human +DTXSID8040278 Css NA 0.152 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040278 Css NA 0.8485 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040278 Css NA 0.1032 mg/L PBTK NA 50% Rat Human +DTXSID8040278 Css NA 0.5608 mg/L PBTK NA 95% Rat Human +DTXSID8040436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040436 Fup 0.617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040436 Vd NA 0.5831 L/kg 1compartment NA NA Human Human DTXSID8040436 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8040436 TK.Half.Life NA 5.527 hours 1compartment NA NA Human Human -DTXSID8040436 Css NA 2.49 mg/L 3compartmentss NA 50% Human Human -DTXSID8040436 Css NA 9.815 mg/L 3compartmentss NA 95% Human Human -DTXSID8040436 Css NA 1.618 mg/L PBTK NA 50% Human Human -DTXSID8040436 Css NA 5.888 mg/L PBTK NA 95% Human Human -DTXSID8040436 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040436 Fup NA 0.3279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040436 Vd NA 0.2952 L/kg 1compartment NA NA Rat Human +DTXSID8040436 TK.Half.Life NA 6.112 hours 1compartment NA NA Human Human +DTXSID8040436 Css NA 0.6728 mg/L 3compartmentss NA 50% Human Human +DTXSID8040436 Css NA 4.672 mg/L 3compartmentss NA 95% Human Human +DTXSID8040436 Css NA 0.5212 mg/L PBTK NA 50% Human Human +DTXSID8040436 Css NA 2.978 mg/L PBTK NA 95% Human Human +DTXSID8040436 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040436 Fup 0.617 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040436 Vd NA 0.6224 L/kg 1compartment NA NA Rat Human DTXSID8040436 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8040436 TK.Half.Life NA 1.984 hours 1compartment NA NA Rat Human -DTXSID8040436 Css NA 0.6993 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040436 Css NA 2.251 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040436 Css NA 0.4273 mg/L PBTK NA 50% Rat Human -DTXSID8040436 Css NA 1.27 mg/L PBTK NA 95% Rat Human -DTXSID8040438 Clint NA 1.965 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040438 Fup NA 0.5992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040438 Vd NA 0.5575 L/kg 1compartment NA NA Human Human +DTXSID8040436 TK.Half.Life NA 2.224 hours 1compartment NA NA Rat Human +DTXSID8040436 Css NA 0.003573 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040436 Css NA 0.02596 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040436 Css NA 0.002647 mg/L PBTK NA 50% Rat Human +DTXSID8040436 Css NA 0.01548 mg/L PBTK NA 95% Rat Human +DTXSID8040438 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040438 Fup 0.888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040438 Vd NA 0.7081 L/kg 1compartment NA NA Human Human DTXSID8040438 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8040438 TK.Half.Life NA 1.634 hours 1compartment NA NA Human Human -DTXSID8040438 Css NA 0.3098 mg/L 3compartmentss NA 50% Human Human -DTXSID8040438 Css NA 2.315 mg/L 3compartmentss NA 95% Human Human -DTXSID8040438 Css NA 0.2364 mg/L PBTK NA 50% Human Human -DTXSID8040438 Css NA 1.481 mg/L PBTK NA 95% Human Human -DTXSID8040438 Clint NA 1.965 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040438 Fup NA 0.5992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040438 Vd NA 0.5865 L/kg 1compartment NA NA Rat Human +DTXSID8040438 TK.Half.Life NA 5.161 hours 1compartment NA NA Human Human +DTXSID8040438 Css NA 0.516 mg/L 3compartmentss NA 50% Human Human +DTXSID8040438 Css NA 2.999 mg/L 3compartmentss NA 95% Human Human +DTXSID8040438 Css NA 0.4218 mg/L PBTK NA 50% Human Human +DTXSID8040438 Css NA 1.949 mg/L PBTK NA 95% Human Human +DTXSID8040438 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040438 Fup 0.888 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040438 Vd NA 0.7451 L/kg 1compartment NA NA Rat Human DTXSID8040438 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8040438 TK.Half.Life NA 0.9 hours 1compartment NA NA Rat Human -DTXSID8040438 Css NA 0.1337 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040438 Css NA 0.9332 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040438 Css NA 0.09862 mg/L PBTK NA 50% Rat Human -DTXSID8040438 Css NA 0.5386 mg/L PBTK NA 95% Rat Human -DTXSID8040484 Clint NA 30.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040484 Fup NA 0.2509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040484 Vd NA 1.522 L/kg 1compartment NA NA Human Human -DTXSID8040484 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8040484 TK.Half.Life NA 1.998 hours 1compartment NA NA Human Human -DTXSID8040484 Css NA 0.0718 mg/L 3compartmentss NA 50% Human Human -DTXSID8040484 Css NA 0.4783 mg/L 3compartmentss NA 95% Human Human -DTXSID8040484 Css NA 0.05299 mg/L PBTK NA 50% Human Human -DTXSID8040484 Css NA 0.3326 mg/L PBTK NA 95% Human Human -DTXSID8040484 Clint NA 30.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040484 Fup NA 0.2509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040484 Vd NA 1.216 L/kg 1compartment NA NA Rat Human +DTXSID8040438 TK.Half.Life NA 1.85 hours 1compartment NA NA Rat Human +DTXSID8040438 Css NA 0.002626 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040438 Css NA 0.01647 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040438 Css NA 0.002097 mg/L PBTK NA 50% Rat Human +DTXSID8040438 Css NA 0.01038 mg/L PBTK NA 95% Rat Human +DTXSID8040484 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040484 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040484 Vd NA 1.146 L/kg 1compartment NA NA Human Human +DTXSID8040484 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8040484 TK.Half.Life NA 21.11 hours 1compartment NA NA Human Human +DTXSID8040484 Css NA 1.87 mg/L 3compartmentss NA 50% Human Human +DTXSID8040484 Css NA 8.017 mg/L 3compartmentss NA 95% Human Human +DTXSID8040484 Css NA 1.476 mg/L PBTK NA 50% Human Human +DTXSID8040484 Css NA 5.227 mg/L PBTK NA 95% Human Human +DTXSID8040484 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040484 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040484 Vd NA 0.9896 L/kg 1compartment NA NA Rat Human DTXSID8040484 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8040484 TK.Half.Life NA 0.7719 hours 1compartment NA NA Rat Human -DTXSID8040484 Css NA 0.0385 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040484 Css NA 0.2104 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040484 Css NA 0.02726 mg/L PBTK NA 50% Rat Human -DTXSID8040484 Css NA 0.139 mg/L PBTK NA 95% Rat Human -DTXSID8040698 Clint NA 39.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040698 Fup NA 0.0881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040698 Vd NA 2.025 L/kg 1compartment NA NA Human Human -DTXSID8040698 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8040698 TK.Half.Life NA 4.888 hours 1compartment NA NA Human Human -DTXSID8040698 Css NA 0.2458 mg/L 3compartmentss NA 50% Human Human -DTXSID8040698 Css NA 1.783 mg/L 3compartmentss NA 95% Human Human -DTXSID8040698 Css NA 0.1647 mg/L PBTK NA 50% Human Human -DTXSID8040698 Css NA 1.141 mg/L PBTK NA 95% Human Human -DTXSID8040698 Clint NA 39.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040698 Fup NA 0.0881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040698 Vd NA 1.529 L/kg 1compartment NA NA Rat Human +DTXSID8040484 TK.Half.Life NA 5.738 hours 1compartment NA NA Rat Human +DTXSID8040484 Css NA 0.1172 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040484 Css NA 0.4501 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040484 Css NA 0.09212 mg/L PBTK NA 50% Rat Human +DTXSID8040484 Css NA 0.2847 mg/L PBTK NA 95% Rat Human +DTXSID8040640 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID8040640 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8040640 Vd NA 15.57 L/kg 1compartment NA NA Human Human +DTXSID8040640 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8040640 TK.Half.Life NA 27.88 hours 1compartment NA NA Human Human +DTXSID8040640 Css NA 0.08166 mg/L 3compartmentss NA 50% Human Human +DTXSID8040640 Css NA 0.6102 mg/L 3compartmentss NA 95% Human Human +DTXSID8040640 Css NA 0.04684 mg/L PBTK NA 50% Human Human +DTXSID8040640 Css NA 0.3526 mg/L PBTK NA 95% Human Human +DTXSID8040640 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID8040640 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8040640 Vd NA 16.42 L/kg 1compartment NA NA Rat Human +DTXSID8040640 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8040640 TK.Half.Life NA 12.41 hours 1compartment NA NA Rat Human +DTXSID8040640 Css NA 0.0007048 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040640 Css NA 0.00478 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040640 Css NA 0.0004098 mg/L PBTK NA 50% Rat Human +DTXSID8040640 Css NA 0.002785 mg/L PBTK NA 95% Rat Human +DTXSID8040694 Clint 864 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID8040694 Fup 0.313 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID8040694 Vd NA 3.056 L/kg 1compartment NA NA Human Human +DTXSID8040694 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8040694 TK.Half.Life NA 2.799 hours 1compartment NA NA Human Human +DTXSID8040694 Css NA 0.01273 mg/L 3compartmentss NA 50% Human Human +DTXSID8040694 Css NA 0.09981 mg/L 3compartmentss NA 95% Human Human +DTXSID8040694 Css NA 0.009092 mg/L PBTK NA 50% Human Human +DTXSID8040694 Css NA 0.06953 mg/L PBTK NA 95% Human Human +DTXSID8040694 Clint 864 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID8040694 Fup 0.313 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID8040694 Vd NA 2.307 L/kg 1compartment NA NA Rat Human +DTXSID8040694 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8040694 TK.Half.Life NA 0.8506 hours 1compartment NA NA Rat Human +DTXSID8040694 Css NA 0.001694 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040694 Css NA 0.01084 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040694 Css NA 0.001217 mg/L PBTK NA 50% Rat Human +DTXSID8040694 Css NA 0.007499 mg/L PBTK NA 95% Rat Human +DTXSID8040698 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040698 Fup 0.0692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040698 Vd NA 2.578 L/kg 1compartment NA NA Human Human +DTXSID8040698 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8040698 TK.Half.Life NA 15.73 hours 1compartment NA NA Human Human +DTXSID8040698 Css NA 0.7312 mg/L 3compartmentss NA 50% Human Human +DTXSID8040698 Css NA 4.688 mg/L 3compartmentss NA 95% Human Human +DTXSID8040698 Css NA 0.4936 mg/L PBTK NA 50% Human Human +DTXSID8040698 Css NA 3.103 mg/L PBTK NA 95% Human Human +DTXSID8040698 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040698 Fup 0.0692 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040698 Vd NA 1.935 L/kg 1compartment NA NA Rat Human DTXSID8040698 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8040698 TK.Half.Life NA 1.611 hours 1compartment NA NA Rat Human -DTXSID8040698 Css NA 0.1364 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040698 Css NA 0.7351 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040698 Css NA 0.08712 mg/L PBTK NA 50% Rat Human -DTXSID8040698 Css NA 0.4533 mg/L PBTK NA 95% Rat Human -DTXSID8040723 Clint NA 5.828 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040723 Fup NA 0.0447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040723 Vd NA 1.365 L/kg 1compartment NA NA Human Human -DTXSID8040723 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8040723 TK.Half.Life NA 20.83 hours 1compartment NA NA Human Human -DTXSID8040723 Css NA 2.468 mg/L 3compartmentss NA 50% Human Human -DTXSID8040723 Css NA 15.52 mg/L 3compartmentss NA 95% Human Human -DTXSID8040723 Css NA 1.555 mg/L PBTK NA 50% Human Human -DTXSID8040723 Css NA 9.429 mg/L PBTK NA 95% Human Human -DTXSID8040723 Clint NA 5.828 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040723 Fup NA 0.0447 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040723 Vd NA 1.026 L/kg 1compartment NA NA Rat Human -DTXSID8040723 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8040723 TK.Half.Life NA 8.126 hours 1compartment NA NA Rat Human -DTXSID8040723 Css NA 1.297 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040723 Css NA 6.442 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040723 Css NA 0.7696 mg/L PBTK NA 50% Rat Human -DTXSID8040723 Css NA 3.645 mg/L PBTK NA 95% Rat Human -DTXSID8040725 Clint NA 0.01933 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040725 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040725 Vd NA 0.3084 L/kg 1compartment NA NA Human Human -DTXSID8040725 Days.Css NA 19 Days PBTK NA NA Human Human -DTXSID8040725 TK.Half.Life NA 93.06 hours 1compartment NA NA Human Human -DTXSID8040725 Css NA 50.32 mg/L 3compartmentss NA 50% Human Human -DTXSID8040725 Css NA 322.5 mg/L 3compartmentss NA 95% Human Human -DTXSID8040725 Css NA 30.58 mg/L PBTK NA 50% Human Human -DTXSID8040725 Css NA 188.3 mg/L PBTK NA 95% Human Human -DTXSID8040725 Clint NA 0.01933 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040725 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040725 Vd NA 0.2929 L/kg 1compartment NA NA Rat Human -DTXSID8040725 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID8040725 TK.Half.Life NA 30.58 hours 1compartment NA NA Rat Human -DTXSID8040725 Css NA 14.55 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040725 Css NA 82.96 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040725 Css NA 8.256 mg/L PBTK NA 50% Rat Human -DTXSID8040725 Css NA 45.22 mg/L PBTK NA 95% Rat Human -DTXSID8040727 Clint NA 12.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040727 Fup NA 0.0761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040727 Vd NA 0.869 L/kg 1compartment NA NA Human Human +DTXSID8040698 TK.Half.Life NA 3.847 hours 1compartment NA NA Rat Human +DTXSID8040698 Css NA 0.09408 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040698 Css NA 0.503 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040698 Css NA 0.06304 mg/L PBTK NA 50% Rat Human +DTXSID8040698 Css NA 0.3258 mg/L PBTK NA 95% Rat Human +DTXSID8040723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040723 Fup 0.0135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040723 Vd NA 2.324 L/kg 1compartment NA NA Human Human +DTXSID8040723 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8040723 TK.Half.Life NA 33.21 hours 1compartment NA NA Human Human +DTXSID8040723 Css NA 2.081 mg/L 3compartmentss NA 50% Human Human +DTXSID8040723 Css NA 16.26 mg/L 3compartmentss NA 95% Human Human +DTXSID8040723 Css NA 1.349 mg/L PBTK NA 50% Human Human +DTXSID8040723 Css NA 10.21 mg/L PBTK NA 95% Human Human +DTXSID8040723 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040723 Fup 0.0135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040723 Vd NA 1.729 L/kg 1compartment NA NA Rat Human +DTXSID8040723 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8040723 TK.Half.Life NA 9.08 hours 1compartment NA NA Rat Human +DTXSID8040723 Css NA 0.2646 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040723 Css NA 1.754 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040723 Css NA 0.169 mg/L PBTK NA 50% Rat Human +DTXSID8040723 Css NA 1.076 mg/L PBTK NA 95% Rat Human +DTXSID8040727 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040727 Fup 0.097 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040727 Vd NA 0.9856 L/kg 1compartment NA NA Human Human DTXSID8040727 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8040727 TK.Half.Life NA 4.042 hours 1compartment NA NA Human Human -DTXSID8040727 Css NA 0.6534 mg/L 3compartmentss NA 50% Human Human -DTXSID8040727 Css NA 4.815 mg/L 3compartmentss NA 95% Human Human -DTXSID8040727 Css NA 0.4134 mg/L PBTK NA 50% Human Human -DTXSID8040727 Css NA 2.904 mg/L PBTK NA 95% Human Human -DTXSID8040727 Clint NA 12.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040727 Fup NA 0.0761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040727 Vd NA 0.6834 L/kg 1compartment NA NA Rat Human +DTXSID8040727 TK.Half.Life NA 6.717 hours 1compartment NA NA Human Human +DTXSID8040727 Css NA 0.9448 mg/L 3compartmentss NA 50% Human Human +DTXSID8040727 Css NA 6.559 mg/L 3compartmentss NA 95% Human Human +DTXSID8040727 Css NA 0.6142 mg/L PBTK NA 50% Human Human +DTXSID8040727 Css NA 3.976 mg/L PBTK NA 95% Human Human +DTXSID8040727 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040727 Fup 0.097 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040727 Vd NA 0.7763 L/kg 1compartment NA NA Rat Human DTXSID8040727 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8040727 TK.Half.Life NA 1.858 hours 1compartment NA NA Rat Human -DTXSID8040727 Css NA 0.362 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040727 Css NA 1.99 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040727 Css NA 0.2147 mg/L PBTK NA 50% Rat Human -DTXSID8040727 Css NA 1.13 mg/L PBTK NA 95% Rat Human -DTXSID8040775 Clint NA 3.588 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040775 Fup NA 0.2615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040775 Vd NA 2.472 L/kg 1compartment NA NA Human Human -DTXSID8040775 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8040775 TK.Half.Life NA 20.99 hours 1compartment NA NA Human Human -DTXSID8040775 Css NA 0.9236 mg/L 3compartmentss NA 50% Human Human -DTXSID8040775 Css NA 4.395 mg/L 3compartmentss NA 95% Human Human -DTXSID8040775 Css NA 0.6889 mg/L PBTK NA 50% Human Human -DTXSID8040775 Css NA 3.058 mg/L PBTK NA 95% Human Human -DTXSID8040775 Clint NA 3.588 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040775 Fup NA 0.2615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040775 Vd NA 1.896 L/kg 1compartment NA NA Rat Human -DTXSID8040775 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8040775 TK.Half.Life NA 5.243 hours 1compartment NA NA Rat Human -DTXSID8040775 Css NA 0.459 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040775 Css NA 1.529 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040775 Css NA 0.3303 mg/L PBTK NA 50% Rat Human -DTXSID8040775 Css NA 1.006 mg/L PBTK NA 95% Rat Human -DTXSID8040779 Clint NA 24.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040779 Fup NA 0.0069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040779 Vd NA 6.703 L/kg 1compartment NA NA Human Human -DTXSID8040779 Days.Css NA 33 Days PBTK NA NA Human Human -DTXSID8040779 TK.Half.Life NA 178.4 hours 1compartment NA NA Human Human -DTXSID8040779 Css NA 2.321 mg/L 3compartmentss NA 50% Human Human -DTXSID8040779 Css NA 12.76 mg/L 3compartmentss NA 95% Human Human -DTXSID8040779 Css NA 2.159 mg/L PBTK NA 50% Human Human -DTXSID8040779 Css NA 11.68 mg/L PBTK NA 95% Human Human -DTXSID8040779 Clint NA 24.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040779 Fup NA 0.0069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040779 Vd NA 5.185 L/kg 1compartment NA NA Rat Human -DTXSID8040779 Days.Css NA 20 Days PBTK NA NA Rat Human -DTXSID8040779 TK.Half.Life NA 25.33 hours 1compartment NA NA Rat Human -DTXSID8040779 Css NA 1.29 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040779 Css NA 5.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040779 Css NA 1.173 mg/L PBTK NA 50% Rat Human -DTXSID8040779 Css NA 5.087 mg/L PBTK NA 95% Rat Human +DTXSID8040727 TK.Half.Life NA 2.986 hours 1compartment NA NA Rat Human +DTXSID8040727 Css NA 0.116 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040727 Css NA 0.5985 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040727 Css NA 0.07298 mg/L PBTK NA 50% Rat Human +DTXSID8040727 Css NA 0.3534 mg/L PBTK NA 95% Rat Human +DTXSID8040779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040779 Fup 0.00745 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8040779 Vd NA 36.06 L/kg 1compartment NA NA Human Human +DTXSID8040779 Days.Css NA 264 Days PBTK NA NA Human Human +DTXSID8040779 TK.Half.Life NA 1075 hours 1compartment NA NA Human Human +DTXSID8040779 Css NA 0.6218 mg/L 3compartmentss NA 50% Human Human +DTXSID8040779 Css NA 3.967 mg/L 3compartmentss NA 95% Human Human +DTXSID8040779 Css NA 2.403 mg/L PBTK NA 50% Human Human +DTXSID8040779 Css NA 14.27 mg/L PBTK NA 95% Human Human +DTXSID8040779 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040779 Fup 0.00745 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8040779 Vd NA 30.01 L/kg 1compartment NA NA Rat Human +DTXSID8040779 Days.Css NA 162 Days PBTK NA NA Rat Human +DTXSID8040779 TK.Half.Life NA 159.3 hours 1compartment NA NA Rat Human +DTXSID8040779 Css NA 0.07451 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040779 Css NA 0.3578 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040779 Css NA 0.3133 mg/L PBTK NA 50% Rat Human +DTXSID8040779 Css NA 1.633 mg/L PBTK NA 95% Rat Human DTXSID8040800 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8040800 Fup NA 0.6977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8040800 Vd NA 0.4444 L/kg 1compartment NA NA Human Human +DTXSID8040800 Vd NA 0.3797 L/kg 1compartment NA NA Human Human DTXSID8040800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8040800 TK.Half.Life NA 4.121 hours 1compartment NA NA Human Human -DTXSID8040800 Css NA 1.208 mg/L 3compartmentss NA 50% Human Human -DTXSID8040800 Css NA 7.415 mg/L 3compartmentss NA 95% Human Human -DTXSID8040800 Css NA 0.8864 mg/L PBTK NA 50% Human Human -DTXSID8040800 Css NA 4.511 mg/L PBTK NA 95% Human Human +DTXSID8040800 TK.Half.Life NA 3.52 hours 1compartment NA NA Human Human +DTXSID8040800 Css NA 1.053 mg/L 3compartmentss NA 50% Human Human +DTXSID8040800 Css NA 6.374 mg/L 3compartmentss NA 95% Human Human +DTXSID8040800 Css NA 0.7514 mg/L PBTK NA 50% Human Human +DTXSID8040800 Css NA 3.899 mg/L PBTK NA 95% Human Human DTXSID8040800 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8040800 Fup NA 0.6977 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8040800 Vd NA 0.4614 L/kg 1compartment NA NA Rat Human +DTXSID8040800 Vd NA 0.4064 L/kg 1compartment NA NA Rat Human DTXSID8040800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8040800 TK.Half.Life NA 1.458 hours 1compartment NA NA Rat Human -DTXSID8040800 Css NA 0.3187 mg/L 3compartmentss NA 50% Rat Human -DTXSID8040800 Css NA 1.896 mg/L 3compartmentss NA 95% Rat Human -DTXSID8040800 Css NA 0.2232 mg/L PBTK NA 50% Rat Human -DTXSID8040800 Css NA 1.086 mg/L PBTK NA 95% Rat Human -DTXSID8041032 Clint NA 7.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8040800 TK.Half.Life NA 1.285 hours 1compartment NA NA Rat Human +DTXSID8040800 Css NA 0.02062 mg/L 3compartmentss NA 50% Rat Human +DTXSID8040800 Css NA 0.1563 mg/L 3compartmentss NA 95% Rat Human +DTXSID8040800 Css NA 0.0139 mg/L PBTK NA 50% Rat Human +DTXSID8040800 Css NA 0.09442 mg/L PBTK NA 95% Rat Human +DTXSID8041032 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8041032 Fup 0.99 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8041032 Vd NA 0.5829 L/kg 1compartment NA NA Human Human DTXSID8041032 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041032 TK.Half.Life NA 0.5093 hours 1compartment NA NA Human Human -DTXSID8041032 Css NA 0.005164 mg/L 3compartmentss NA 50% Human Human -DTXSID8041032 Css NA 0.04572 mg/L 3compartmentss NA 95% Human Human -DTXSID8041032 Css NA 0.004826 mg/L PBTK NA 50% Human Human -DTXSID8041032 Css NA 0.03521 mg/L PBTK NA 95% Human Human -DTXSID8041032 Clint NA 7.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8041032 TK.Half.Life NA 3.809 hours 1compartment NA NA Human Human +DTXSID8041032 Css NA 0.368 mg/L 3compartmentss NA 50% Human Human +DTXSID8041032 Css NA 1.725 mg/L 3compartmentss NA 95% Human Human +DTXSID8041032 Css NA 0.3975 mg/L PBTK NA 50% Human Human +DTXSID8041032 Css NA 1.863 mg/L PBTK NA 95% Human Human +DTXSID8041032 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8041032 Fup 0.99 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8041032 Vd NA 0.618 L/kg 1compartment NA NA Rat Human DTXSID8041032 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041032 TK.Half.Life NA 0.2813 hours 1compartment NA NA Rat Human -DTXSID8041032 Css NA 0.0271 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041032 Css NA 0.2056 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041032 Css NA 0.02555 mg/L PBTK NA 50% Rat Human -DTXSID8041032 Css NA 0.1426 mg/L PBTK NA 95% Rat Human -DTXSID8041034 Clint NA 142.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8041032 TK.Half.Life NA 1.376 hours 1compartment NA NA Rat Human +DTXSID8041032 Css NA 0.001837 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041032 Css NA 0.009434 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041032 Css NA 0.001988 mg/L PBTK NA 50% Rat Human +DTXSID8041032 Css NA 0.01021 mg/L PBTK NA 95% Rat Human +DTXSID8041034 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID8041034 Fup 0.089 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8041034 Vd NA 1.706 L/kg 1compartment NA NA Human Human -DTXSID8041034 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041034 TK.Half.Life NA 1.917 hours 1compartment NA NA Human Human -DTXSID8041034 Css NA 0.0512 mg/L 3compartmentss NA 50% Human Human -DTXSID8041034 Css NA 0.4315 mg/L 3compartmentss NA 95% Human Human -DTXSID8041034 Css NA 0.03534 mg/L PBTK NA 50% Human Human -DTXSID8041034 Css NA 0.2799 mg/L PBTK NA 95% Human Human -DTXSID8041034 Clint NA 142.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8041034 Vd NA 2.142 L/kg 1compartment NA NA Human Human +DTXSID8041034 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8041034 TK.Half.Life NA 28.25 hours 1compartment NA NA Human Human +DTXSID8041034 Css NA 1.732 mg/L 3compartmentss NA 50% Human Human +DTXSID8041034 Css NA 10.43 mg/L 3compartmentss NA 95% Human Human +DTXSID8041034 Css NA 1.229 mg/L PBTK NA 50% Human Human +DTXSID8041034 Css NA 6.625 mg/L PBTK NA 95% Human Human +DTXSID8041034 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID8041034 Fup 0.089 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8041034 Vd NA 1.429 L/kg 1compartment NA NA Rat Human -DTXSID8041034 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041034 TK.Half.Life NA 0.7673 hours 1compartment NA NA Rat Human -DTXSID8041034 Css NA 0.02891 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041034 Css NA 0.2029 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041034 Css NA 0.01904 mg/L PBTK NA 50% Rat Human -DTXSID8041034 Css NA 0.1251 mg/L PBTK NA 95% Rat Human -DTXSID8041080 Clint NA 7.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041080 Fup NA 0.3741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041080 Vd NA 0.4703 L/kg 1compartment NA NA Human Human +DTXSID8041034 Vd NA 1.74 L/kg 1compartment NA NA Rat Human +DTXSID8041034 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8041034 TK.Half.Life NA 10.15 hours 1compartment NA NA Rat Human +DTXSID8041034 Css NA 0.204 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041034 Css NA 0.8967 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041034 Css NA 0.1429 mg/L PBTK NA 50% Rat Human +DTXSID8041034 Css NA 0.56 mg/L PBTK NA 95% Rat Human +DTXSID8041080 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041080 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041080 Vd NA 0.6008 L/kg 1compartment NA NA Human Human DTXSID8041080 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041080 TK.Half.Life NA 0.9222 hours 1compartment NA NA Human Human -DTXSID8041080 Css NA 0.1614 mg/L 3compartmentss NA 50% Human Human -DTXSID8041080 Css NA 1.088 mg/L 3compartmentss NA 95% Human Human -DTXSID8041080 Css NA 0.1139 mg/L PBTK NA 50% Human Human -DTXSID8041080 Css NA 0.7031 mg/L PBTK NA 95% Human Human -DTXSID8041080 Clint NA 7.392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041080 Fup NA 0.3741 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041080 Vd NA 0.4848 L/kg 1compartment NA NA Rat Human +DTXSID8041080 TK.Half.Life NA 0.9267 hours 1compartment NA NA Human Human +DTXSID8041080 Css NA 0.1178 mg/L 3compartmentss NA 50% Human Human +DTXSID8041080 Css NA 1.024 mg/L 3compartmentss NA 95% Human Human +DTXSID8041080 Css NA 0.09 mg/L PBTK NA 50% Human Human +DTXSID8041080 Css NA 0.665 mg/L PBTK NA 95% Human Human +DTXSID8041080 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041080 Fup 0.583 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041080 Vd NA 0.6212 L/kg 1compartment NA NA Rat Human DTXSID8041080 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041080 TK.Half.Life NA 0.5299 hours 1compartment NA NA Rat Human -DTXSID8041080 Css NA 0.08276 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041080 Css NA 0.416 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041080 Css NA 0.05604 mg/L PBTK NA 50% Rat Human -DTXSID8041080 Css NA 0.2522 mg/L PBTK NA 95% Rat Human -DTXSID8041115 Clint NA 57.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041115 Fup NA 0.1011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041115 Vd NA 2.23 L/kg 1compartment NA NA Human Human +DTXSID8041080 TK.Half.Life NA 0.5173 hours 1compartment NA NA Rat Human +DTXSID8041080 Css NA 0.01335 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041080 Css NA 0.1022 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041080 Css NA 0.01024 mg/L PBTK NA 50% Rat Human +DTXSID8041080 Css NA 0.06305 mg/L PBTK NA 95% Rat Human +DTXSID8041115 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041115 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041115 Vd NA 2.717 L/kg 1compartment NA NA Human Human DTXSID8041115 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041115 TK.Half.Life NA 3.697 hours 1compartment NA NA Human Human -DTXSID8041115 Css NA 0.1301 mg/L 3compartmentss NA 50% Human Human -DTXSID8041115 Css NA 0.9556 mg/L 3compartmentss NA 95% Human Human -DTXSID8041115 Css NA 0.09268 mg/L PBTK NA 50% Human Human -DTXSID8041115 Css NA 0.6437 mg/L PBTK NA 95% Human Human -DTXSID8041115 Clint NA 57.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041115 Fup NA 0.1011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041115 Vd NA 1.81 L/kg 1compartment NA NA Rat Human +DTXSID8041115 TK.Half.Life NA 7.444 hours 1compartment NA NA Human Human +DTXSID8041115 Css NA 0.2176 mg/L 3compartmentss NA 50% Human Human +DTXSID8041115 Css NA 1.562 mg/L 3compartmentss NA 95% Human Human +DTXSID8041115 Css NA 0.1646 mg/L PBTK NA 50% Human Human +DTXSID8041115 Css NA 1.101 mg/L PBTK NA 95% Human Human +DTXSID8041115 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041115 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041115 Vd NA 2.212 L/kg 1compartment NA NA Rat Human DTXSID8041115 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041115 TK.Half.Life NA 1.366 hours 1compartment NA NA Rat Human -DTXSID8041115 Css NA 0.0714 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041115 Css NA 0.4382 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041115 Css NA 0.0486 mg/L PBTK NA 50% Rat Human -DTXSID8041115 Css NA 0.2809 mg/L PBTK NA 95% Rat Human -DTXSID8041117 Clint NA 323.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041117 Fup NA 0.3095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041117 Vd NA 3.105 L/kg 1compartment NA NA Human Human -DTXSID8041117 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041117 TK.Half.Life NA 2.08 hours 1compartment NA NA Human Human -DTXSID8041117 Css NA 0.006522 mg/L 3compartmentss NA 50% Human Human -DTXSID8041117 Css NA 0.04705 mg/L 3compartmentss NA 95% Human Human -DTXSID8041117 Css NA 0.005836 mg/L PBTK NA 50% Human Human -DTXSID8041117 Css NA 0.03892 mg/L PBTK NA 95% Human Human -DTXSID8041117 Clint NA 323.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041117 Fup NA 0.3095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041117 Vd NA 2.707 L/kg 1compartment NA NA Rat Human -DTXSID8041117 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041117 TK.Half.Life NA 0.7824 hours 1compartment NA NA Rat Human -DTXSID8041117 Css NA 0.00355 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041117 Css NA 0.02085 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041117 Css NA 0.003112 mg/L PBTK NA 50% Rat Human -DTXSID8041117 Css NA 0.01663 mg/L PBTK NA 95% Rat Human +DTXSID8041115 TK.Half.Life NA 2.407 hours 1compartment NA NA Rat Human +DTXSID8041115 Css NA 0.01048 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041115 Css NA 0.08052 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041115 Css NA 0.007836 mg/L PBTK NA 50% Rat Human +DTXSID8041115 Css NA 0.05571 mg/L PBTK NA 95% Rat Human +DTXSID8041117 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041117 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041117 Vd NA 3.234 L/kg 1compartment NA NA Human Human +DTXSID8041117 Days.Css NA 39 Days PBTK NA NA Human Human +DTXSID8041117 TK.Half.Life NA 193.1 hours 1compartment NA NA Human Human +DTXSID8041117 Css NA 4.832 mg/L 3compartmentss NA 50% Human Human +DTXSID8041117 Css NA 16.42 mg/L 3compartmentss NA 95% Human Human +DTXSID8041117 Css NA 4.198 mg/L PBTK NA 50% Human Human +DTXSID8041117 Css NA 12.02 mg/L PBTK NA 95% Human Human +DTXSID8041117 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041117 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041117 Vd NA 2.731 L/kg 1compartment NA NA Rat Human +DTXSID8041117 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID8041117 TK.Half.Life NA 29 hours 1compartment NA NA Rat Human +DTXSID8041117 Css NA 0.1164 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041117 Css NA 0.5355 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041117 Css NA 0.1006 mg/L PBTK NA 50% Rat Human +DTXSID8041117 Css NA 0.4034 mg/L PBTK NA 95% Rat Human DTXSID8041246 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8041246 Fup NA 0.864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8041246 Vd NA 0.7185 L/kg 1compartment NA NA Human Human DTXSID8041246 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8041246 TK.Half.Life NA 5.382 hours 1compartment NA NA Human Human -DTXSID8041246 Css NA 0.9548 mg/L 3compartmentss NA 50% Human Human -DTXSID8041246 Css NA 5.588 mg/L 3compartmentss NA 95% Human Human -DTXSID8041246 Css NA 0.7838 mg/L PBTK NA 50% Human Human -DTXSID8041246 Css NA 3.588 mg/L PBTK NA 95% Human Human +DTXSID8041246 Css NA 0.8106 mg/L 3compartmentss NA 50% Human Human +DTXSID8041246 Css NA 4.87 mg/L 3compartmentss NA 95% Human Human +DTXSID8041246 Css NA 0.6647 mg/L PBTK NA 50% Human Human +DTXSID8041246 Css NA 3.124 mg/L PBTK NA 95% Human Human DTXSID8041246 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8041246 Fup NA 0.864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8041246 Vd NA 0.7517 L/kg 1compartment NA NA Rat Human DTXSID8041246 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8041246 TK.Half.Life NA 1.918 hours 1compartment NA NA Rat Human -DTXSID8041246 Css NA 0.2436 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041246 Css NA 1.401 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041246 Css NA 0.194 mg/L PBTK NA 50% Rat Human -DTXSID8041246 Css NA 0.8395 mg/L PBTK NA 95% Rat Human +DTXSID8041246 Css NA 0.01506 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041246 Css NA 0.113 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041246 Css NA 0.01185 mg/L PBTK NA 50% Rat Human +DTXSID8041246 Css NA 0.07402 mg/L PBTK NA 95% Rat Human DTXSID8041248 Clint 117 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8041248 Fup 1.83e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8041248 Vd NA 0.4085 L/kg 1compartment NA NA Human Human -DTXSID8041248 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID8041248 TK.Half.Life NA 35.03 hours 1compartment NA NA Human Human -DTXSID8041248 Css NA 0.4876 mg/L 3compartmentss NA 50% Human Human -DTXSID8041248 Css NA 8.794 mg/L 3compartmentss NA 95% Human Human -DTXSID8041248 Css NA 0.3266 mg/L PBTK NA 50% Human Human -DTXSID8041248 Css NA 5.608 mg/L PBTK NA 95% Human Human +DTXSID8041248 Vd NA 0.1642 L/kg 1compartment NA NA Human Human +DTXSID8041248 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID8041248 TK.Half.Life NA 48.34 hours 1compartment NA NA Human Human +DTXSID8041248 Css NA 0.4024 mg/L 3compartmentss NA 50% Human Human +DTXSID8041248 Css NA 12.79 mg/L 3compartmentss NA 95% Human Human +DTXSID8041248 Css NA 0.242 mg/L PBTK NA 50% Human Human +DTXSID8041248 Css NA 7.623 mg/L PBTK NA 95% Human Human DTXSID8041248 Clint 117 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8041248 Fup 1.83e-07 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8041248 Vd NA 0.3086 L/kg 1compartment NA NA Rat Human -DTXSID8041248 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8041248 TK.Half.Life NA 18.47 hours 1compartment NA NA Rat Human -DTXSID8041248 Css NA 0.2864 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041248 Css NA 4.364 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041248 Css NA 0.1811 mg/L PBTK NA 50% Rat Human -DTXSID8041248 Css NA 2.636 mg/L PBTK NA 95% Rat Human -DTXSID8041298 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041298 Fup NA 0.8548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041298 Vd NA 0.9871 L/kg 1compartment NA NA Human Human +DTXSID8041248 Vd NA 0.1602 L/kg 1compartment NA NA Rat Human +DTXSID8041248 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID8041248 TK.Half.Life NA 32.93 hours 1compartment NA NA Rat Human +DTXSID8041248 Css NA 0.05404 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041248 Css NA 1.428 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041248 Css NA 0.03114 mg/L PBTK NA 50% Rat Human +DTXSID8041248 Css NA 0.8049 mg/L PBTK NA 95% Rat Human +DTXSID8041298 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041298 Fup 0.67 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041298 Vd NA 0.8064 L/kg 1compartment NA NA Human Human DTXSID8041298 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041298 TK.Half.Life NA 7.605 hours 1compartment NA NA Human Human -DTXSID8041298 Css NA 0.908 mg/L 3compartmentss NA 50% Human Human -DTXSID8041298 Css NA 5.711 mg/L 3compartmentss NA 95% Human Human -DTXSID8041298 Css NA 0.7912 mg/L PBTK NA 50% Human Human -DTXSID8041298 Css NA 3.712 mg/L PBTK NA 95% Human Human -DTXSID8041298 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041298 Fup NA 0.8548 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041298 Vd NA 0.9726 L/kg 1compartment NA NA Rat Human +DTXSID8041298 TK.Half.Life NA 7.862 hours 1compartment NA NA Human Human +DTXSID8041298 Css NA 1.076 mg/L 3compartmentss NA 50% Human Human +DTXSID8041298 Css NA 7.179 mg/L 3compartmentss NA 95% Human Human +DTXSID8041298 Css NA 0.8855 mg/L PBTK NA 50% Human Human +DTXSID8041298 Css NA 4.533 mg/L PBTK NA 95% Human Human +DTXSID8041298 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041298 Fup 0.67 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041298 Vd NA 0.8022 L/kg 1compartment NA NA Rat Human DTXSID8041298 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041298 TK.Half.Life NA 2.52 hours 1compartment NA NA Rat Human -DTXSID8041298 Css NA 0.2304 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041298 Css NA 1.398 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041298 Css NA 0.1963 mg/L PBTK NA 50% Rat Human -DTXSID8041298 Css NA 0.8551 mg/L PBTK NA 95% Rat Human +DTXSID8041298 TK.Half.Life NA 2.646 hours 1compartment NA NA Rat Human +DTXSID8041298 Css NA 0.06479 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041298 Css NA 0.4055 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041298 Css NA 0.05358 mg/L PBTK NA 50% Rat Human +DTXSID8041298 Css NA 0.2494 mg/L PBTK NA 95% Rat Human DTXSID8041321 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8041321 Fup NA 0.9532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041321 Vd NA 0.774 L/kg 1compartment NA NA Human Human +DTXSID8041321 Vd NA 0.7749 L/kg 1compartment NA NA Human Human DTXSID8041321 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041321 TK.Half.Life NA 5.259 hours 1compartment NA NA Human Human -DTXSID8041321 Css NA 0.9038 mg/L 3compartmentss NA 50% Human Human -DTXSID8041321 Css NA 5.014 mg/L 3compartmentss NA 95% Human Human -DTXSID8041321 Css NA 0.7513 mg/L PBTK NA 50% Human Human -DTXSID8041321 Css NA 3.298 mg/L PBTK NA 95% Human Human +DTXSID8041321 TK.Half.Life NA 5.267 hours 1compartment NA NA Human Human +DTXSID8041321 Css NA 0.7652 mg/L 3compartmentss NA 50% Human Human +DTXSID8041321 Css NA 4.205 mg/L 3compartmentss NA 95% Human Human +DTXSID8041321 Css NA 0.6397 mg/L PBTK NA 50% Human Human +DTXSID8041321 Css NA 2.759 mg/L PBTK NA 95% Human Human DTXSID8041321 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8041321 Fup NA 0.9532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041321 Vd NA 0.8079 L/kg 1compartment NA NA Rat Human +DTXSID8041321 Vd NA 0.8089 L/kg 1compartment NA NA Rat Human DTXSID8041321 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041321 TK.Half.Life NA 1.869 hours 1compartment NA NA Rat Human -DTXSID8041321 Css NA 0.2261 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041321 Css NA 1.266 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041321 Css NA 0.184 mg/L PBTK NA 50% Rat Human -DTXSID8041321 Css NA 0.7665 mg/L PBTK NA 95% Rat Human -DTXSID8041327 Clint NA 0.009503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041327 Fup NA 0.4157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041327 Vd NA 0.3772 L/kg 1compartment NA NA Human Human +DTXSID8041321 TK.Half.Life NA 1.871 hours 1compartment NA NA Rat Human +DTXSID8041321 Css NA 0.01401 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041321 Css NA 0.09886 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041321 Css NA 0.01122 mg/L PBTK NA 50% Rat Human +DTXSID8041321 Css NA 0.06597 mg/L PBTK NA 95% Rat Human +DTXSID8041327 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041327 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041327 Vd NA 0.5093 L/kg 1compartment NA NA Human Human DTXSID8041327 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041327 TK.Half.Life NA 5.776 hours 1compartment NA NA Human Human -DTXSID8041327 Css NA 1.83 mg/L 3compartmentss NA 50% Human Human -DTXSID8041327 Css NA 7.79 mg/L 3compartmentss NA 95% Human Human -DTXSID8041327 Css NA 1.27 mg/L PBTK NA 50% Human Human -DTXSID8041327 Css NA 4.788 mg/L PBTK NA 95% Human Human -DTXSID8041327 Clint NA 0.009503 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041327 Fup NA 0.4157 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041327 Vd NA 0.3858 L/kg 1compartment NA NA Rat Human +DTXSID8041327 TK.Half.Life NA 7.354 hours 1compartment NA NA Human Human +DTXSID8041327 Css NA 0.8722 mg/L 3compartmentss NA 50% Human Human +DTXSID8041327 Css NA 4.333 mg/L 3compartmentss NA 95% Human Human +DTXSID8041327 Css NA 0.6552 mg/L PBTK NA 50% Human Human +DTXSID8041327 Css NA 2.761 mg/L PBTK NA 95% Human Human +DTXSID8041327 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041327 Fup 0.448 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041327 Vd NA 0.5223 L/kg 1compartment NA NA Rat Human DTXSID8041327 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041327 TK.Half.Life NA 2.03 hours 1compartment NA NA Rat Human -DTXSID8041327 Css NA 0.5102 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041327 Css NA 1.918 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041327 Css NA 0.336 mg/L PBTK NA 50% Rat Human -DTXSID8041327 Css NA 1.105 mg/L PBTK NA 95% Rat Human -DTXSID8041329 Clint NA 11.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041329 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041329 Vd NA 2.953 L/kg 1compartment NA NA Human Human -DTXSID8041329 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID8041329 TK.Half.Life NA 128.5 hours 1compartment NA NA Human Human -DTXSID8041329 Css NA 5.709 mg/L 3compartmentss NA 50% Human Human -DTXSID8041329 Css NA 37.98 mg/L 3compartmentss NA 95% Human Human -DTXSID8041329 Css NA 3.888 mg/L PBTK NA 50% Human Human -DTXSID8041329 Css NA 25.31 mg/L PBTK NA 95% Human Human -DTXSID8041329 Clint NA 11.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041329 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041329 Vd NA 2.21 L/kg 1compartment NA NA Rat Human -DTXSID8041329 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID8041329 TK.Half.Life NA 20.94 hours 1compartment NA NA Rat Human -DTXSID8041329 Css NA 3.232 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041329 Css NA 16.94 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041329 Css NA 2.101 mg/L PBTK NA 50% Rat Human -DTXSID8041329 Css NA 10.73 mg/L PBTK NA 95% Rat Human -DTXSID8041371 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041371 Fup NA 0.6723 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041371 Vd NA 0.6947 L/kg 1compartment NA NA Human Human +DTXSID8041327 TK.Half.Life NA 2.571 hours 1compartment NA NA Rat Human +DTXSID8041327 Css NA 0.004658 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041327 Css NA 0.02404 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041327 Css NA 0.003324 mg/L PBTK NA 50% Rat Human +DTXSID8041327 Css NA 0.01476 mg/L PBTK NA 95% Rat Human +DTXSID8041329 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041329 Fup 0.00855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041329 Vd NA 2.925 L/kg 1compartment NA NA Human Human +DTXSID8041329 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID8041329 TK.Half.Life NA 69.48 hours 1compartment NA NA Human Human +DTXSID8041329 Css NA 3.053 mg/L 3compartmentss NA 50% Human Human +DTXSID8041329 Css NA 20.44 mg/L 3compartmentss NA 95% Human Human +DTXSID8041329 Css NA 2.08 mg/L PBTK NA 50% Human Human +DTXSID8041329 Css NA 13.76 mg/L PBTK NA 95% Human Human +DTXSID8041329 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041329 Fup 0.00855 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041329 Vd NA 2.188 L/kg 1compartment NA NA Rat Human +DTXSID8041329 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID8041329 TK.Half.Life NA 11.87 hours 1compartment NA NA Rat Human +DTXSID8041329 Css NA 0.3965 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041329 Css NA 2.289 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041329 Css NA 0.2663 mg/L PBTK NA 50% Rat Human +DTXSID8041329 Css NA 1.5 mg/L PBTK NA 95% Rat Human +DTXSID8041371 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041371 Fup 0.709 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041371 Vd NA 0.6729 L/kg 1compartment NA NA Human Human DTXSID8041371 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041371 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human -DTXSID8041371 Css NA 1.125 mg/L 3compartmentss NA 50% Human Human -DTXSID8041371 Css NA 7.073 mg/L 3compartmentss NA 95% Human Human -DTXSID8041371 Css NA 0.9035 mg/L PBTK NA 50% Human Human -DTXSID8041371 Css NA 4.547 mg/L PBTK NA 95% Human Human -DTXSID8041371 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041371 Fup NA 0.6723 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041371 Vd NA 0.71 L/kg 1compartment NA NA Rat Human +DTXSID8041371 TK.Half.Life NA 6.145 hours 1compartment NA NA Human Human +DTXSID8041371 Css NA 1.05 mg/L 3compartmentss NA 50% Human Human +DTXSID8041371 Css NA 6.924 mg/L 3compartmentss NA 95% Human Human +DTXSID8041371 Css NA 0.8478 mg/L PBTK NA 50% Human Human +DTXSID8041371 Css NA 4.392 mg/L PBTK NA 95% Human Human +DTXSID8041371 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041371 Fup 0.709 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041371 Vd NA 0.6955 L/kg 1compartment NA NA Rat Human DTXSID8041371 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041371 TK.Half.Life NA 2.33 hours 1compartment NA NA Rat Human -DTXSID8041371 Css NA 0.2938 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041371 Css NA 1.833 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041371 Css NA 0.2278 mg/L PBTK NA 50% Rat Human -DTXSID8041371 Css NA 1.081 mg/L PBTK NA 95% Rat Human -DTXSID8041373 Clint NA 0.332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041373 Fup NA 0.2742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041373 Vd NA 2.053 L/kg 1compartment NA NA Human Human -DTXSID8041373 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID8041373 TK.Half.Life NA 52.83 hours 1compartment NA NA Human Human -DTXSID8041373 Css NA 2.788 mg/L 3compartmentss NA 50% Human Human -DTXSID8041373 Css NA 9.528 mg/L 3compartmentss NA 95% Human Human -DTXSID8041373 Css NA 2.102 mg/L PBTK NA 50% Human Human -DTXSID8041373 Css NA 6.334 mg/L PBTK NA 95% Human Human -DTXSID8041373 Clint NA 0.332 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041373 Fup NA 0.2742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041373 Vd NA 1.601 L/kg 1compartment NA NA Rat Human -DTXSID8041373 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8041373 TK.Half.Life NA 11.68 hours 1compartment NA NA Rat Human -DTXSID8041373 Css NA 0.9571 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041373 Css NA 2.627 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041373 Css NA 0.6937 mg/L PBTK NA 50% Rat Human -DTXSID8041373 Css NA 1.63 mg/L PBTK NA 95% Rat Human -DTXSID8041379 Clint NA 29.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041379 Fup NA 0.0261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041379 Vd NA 3.089 L/kg 1compartment NA NA Human Human -DTXSID8041379 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID8041379 TK.Half.Life NA 55.32 hours 1compartment NA NA Human Human -DTXSID8041379 Css NA 2.183 mg/L 3compartmentss NA 50% Human Human -DTXSID8041379 Css NA 13.61 mg/L 3compartmentss NA 95% Human Human -DTXSID8041379 Css NA 1.512 mg/L PBTK NA 50% Human Human -DTXSID8041379 Css NA 9.074 mg/L PBTK NA 95% Human Human -DTXSID8041379 Clint NA 29.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041379 Fup NA 0.0261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041379 Vd NA 2.314 L/kg 1compartment NA NA Rat Human -DTXSID8041379 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID8041379 TK.Half.Life NA 7.952 hours 1compartment NA NA Rat Human -DTXSID8041379 Css NA 1.224 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041379 Css NA 6.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041379 Css NA 0.8101 mg/L PBTK NA 50% Rat Human -DTXSID8041379 Css NA 4.087 mg/L PBTK NA 95% Rat Human -DTXSID8041400 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041400 Fup NA 0.4725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041400 Vd NA 1.568 L/kg 1compartment NA NA Human Human -DTXSID8041400 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8041400 TK.Half.Life NA 27.09 hours 1compartment NA NA Human Human -DTXSID8041400 Css NA 1.755 mg/L 3compartmentss NA 50% Human Human -DTXSID8041400 Css NA 7.842 mg/L 3compartmentss NA 95% Human Human -DTXSID8041400 Css NA 1.457 mg/L PBTK NA 50% Human Human -DTXSID8041400 Css NA 5.304 mg/L PBTK NA 95% Human Human -DTXSID8041400 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041400 Fup NA 0.4725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041400 Vd NA 1.309 L/kg 1compartment NA NA Rat Human +DTXSID8041371 TK.Half.Life NA 2.164 hours 1compartment NA NA Rat Human +DTXSID8041371 Css NA 0.06299 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041371 Css NA 0.4086 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041371 Css NA 0.05071 mg/L PBTK NA 50% Rat Human +DTXSID8041371 Css NA 0.2483 mg/L PBTK NA 95% Rat Human +DTXSID8041373 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041373 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041373 Vd NA 0.5142 L/kg 1compartment NA NA Human Human +DTXSID8041373 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8041373 TK.Half.Life NA 10.24 hours 1compartment NA NA Human Human +DTXSID8041373 Css NA 2.222 mg/L 3compartmentss NA 50% Human Human +DTXSID8041373 Css NA 8.94 mg/L 3compartmentss NA 95% Human Human +DTXSID8041373 Css NA 1.583 mg/L PBTK NA 50% Human Human +DTXSID8041373 Css NA 5.623 mg/L PBTK NA 95% Human Human +DTXSID8041373 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041373 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041373 Vd NA 0.5127 L/kg 1compartment NA NA Rat Human +DTXSID8041373 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8041373 TK.Half.Life NA 3.471 hours 1compartment NA NA Rat Human +DTXSID8041373 Css NA 0.1442 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041373 Css NA 0.4936 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041373 Css NA 0.1006 mg/L PBTK NA 50% Rat Human +DTXSID8041373 Css NA 0.2993 mg/L PBTK NA 95% Rat Human +DTXSID8041379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041379 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041379 Vd NA 3.114 L/kg 1compartment NA NA Human Human +DTXSID8041379 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID8041379 TK.Half.Life NA 88.03 hours 1compartment NA NA Human Human +DTXSID8041379 Css NA 3.362 mg/L 3compartmentss NA 50% Human Human +DTXSID8041379 Css NA 20.9 mg/L 3compartmentss NA 95% Human Human +DTXSID8041379 Css NA 2.332 mg/L PBTK NA 50% Human Human +DTXSID8041379 Css NA 13.97 mg/L PBTK NA 95% Human Human +DTXSID8041379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041379 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041379 Vd NA 2.334 L/kg 1compartment NA NA Rat Human +DTXSID8041379 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID8041379 TK.Half.Life NA 11.95 hours 1compartment NA NA Rat Human +DTXSID8041379 Css NA 0.4347 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041379 Css NA 2.239 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041379 Css NA 0.2978 mg/L PBTK NA 50% Rat Human +DTXSID8041379 Css NA 1.478 mg/L PBTK NA 95% Rat Human +DTXSID8041400 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041400 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041400 Vd NA 1.824 L/kg 1compartment NA NA Human Human +DTXSID8041400 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8041400 TK.Half.Life NA 2.056 hours 1compartment NA NA Human Human +DTXSID8041400 Css NA 0.05188 mg/L 3compartmentss NA 50% Human Human +DTXSID8041400 Css NA 0.4116 mg/L 3compartmentss NA 95% Human Human +DTXSID8041400 Css NA 0.04271 mg/L PBTK NA 50% Human Human +DTXSID8041400 Css NA 0.3007 mg/L PBTK NA 95% Human Human +DTXSID8041400 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041400 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041400 Vd NA 1.485 L/kg 1compartment NA NA Rat Human DTXSID8041400 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041400 TK.Half.Life NA 6.49 hours 1compartment NA NA Rat Human -DTXSID8041400 Css NA 0.4707 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041400 Css NA 1.807 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041400 Css NA 0.3777 mg/L PBTK NA 50% Rat Human -DTXSID8041400 Css NA 1.134 mg/L PBTK NA 95% Rat Human -DTXSID8041404 Clint NA 14.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041404 Fup NA 0.1068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041404 Vd NA 2.354 L/kg 1compartment NA NA Human Human +DTXSID8041400 TK.Half.Life NA 0.7722 hours 1compartment NA NA Rat Human +DTXSID8041400 Css NA 0.006358 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041400 Css NA 0.03946 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041400 Css NA 0.005304 mg/L PBTK NA 50% Rat Human +DTXSID8041400 Css NA 0.02939 mg/L PBTK NA 95% Rat Human +DTXSID8041404 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041404 Fup 0.076 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041404 Vd NA 1.487 L/kg 1compartment NA NA Human Human DTXSID8041404 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041404 TK.Half.Life NA 12.54 hours 1compartment NA NA Human Human -DTXSID8041404 Css NA 0.6547 mg/L 3compartmentss NA 50% Human Human -DTXSID8041404 Css NA 4.299 mg/L 3compartmentss NA 95% Human Human -DTXSID8041404 Css NA 0.449 mg/L PBTK NA 50% Human Human -DTXSID8041404 Css NA 2.777 mg/L PBTK NA 95% Human Human -DTXSID8041404 Clint NA 14.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041404 Fup NA 0.1068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041404 Vd NA 1.778 L/kg 1compartment NA NA Rat Human +DTXSID8041404 TK.Half.Life NA 5.131 hours 1compartment NA NA Human Human +DTXSID8041404 Css NA 0.4097 mg/L 3compartmentss NA 50% Human Human +DTXSID8041404 Css NA 2.961 mg/L 3compartmentss NA 95% Human Human +DTXSID8041404 Css NA 0.267 mg/L PBTK NA 50% Human Human +DTXSID8041404 Css NA 1.846 mg/L PBTK NA 95% Human Human +DTXSID8041404 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041404 Fup 0.076 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041404 Vd NA 1.129 L/kg 1compartment NA NA Rat Human DTXSID8041404 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041404 TK.Half.Life NA 3.511 hours 1compartment NA NA Rat Human -DTXSID8041404 Css NA 0.3566 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041404 Css NA 1.778 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041404 Css NA 0.2325 mg/L PBTK NA 50% Rat Human -DTXSID8041404 Css NA 1.102 mg/L PBTK NA 95% Rat Human -DTXSID8041452 Clint NA 16.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041452 Fup NA 0.0869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041452 Vd NA 2.603 L/kg 1compartment NA NA Human Human +DTXSID8041404 TK.Half.Life NA 1.99 hours 1compartment NA NA Rat Human +DTXSID8041404 Css NA 0.05336 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041404 Css NA 0.3028 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041404 Css NA 0.03395 mg/L PBTK NA 50% Rat Human +DTXSID8041404 Css NA 0.1855 mg/L PBTK NA 95% Rat Human +DTXSID8041452 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041452 Fup 0.0327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041452 Vd NA 2.199 L/kg 1compartment NA NA Human Human DTXSID8041452 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8041452 TK.Half.Life NA 18.01 hours 1compartment NA NA Human Human -DTXSID8041452 Css NA 0.8512 mg/L 3compartmentss NA 50% Human Human -DTXSID8041452 Css NA 5.475 mg/L 3compartmentss NA 95% Human Human -DTXSID8041452 Css NA 0.587 mg/L PBTK NA 50% Human Human -DTXSID8041452 Css NA 3.555 mg/L PBTK NA 95% Human Human -DTXSID8041452 Clint NA 16.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041452 Fup NA 0.0869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041452 Vd NA 1.958 L/kg 1compartment NA NA Rat Human +DTXSID8041452 TK.Half.Life NA 17.41 hours 1compartment NA NA Human Human +DTXSID8041452 Css NA 1.092 mg/L 3compartmentss NA 50% Human Human +DTXSID8041452 Css NA 8.513 mg/L 3compartmentss NA 95% Human Human +DTXSID8041452 Css NA 0.719 mg/L PBTK NA 50% Human Human +DTXSID8041452 Css NA 5.413 mg/L PBTK NA 95% Human Human +DTXSID8041452 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041452 Fup 0.0327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041452 Vd NA 1.642 L/kg 1compartment NA NA Rat Human DTXSID8041452 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041452 TK.Half.Life NA 4.303 hours 1compartment NA NA Rat Human -DTXSID8041452 Css NA 0.4706 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041452 Css NA 2.347 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041452 Css NA 0.307 mg/L PBTK NA 50% Rat Human -DTXSID8041452 Css NA 1.459 mg/L PBTK NA 95% Rat Human +DTXSID8041452 TK.Half.Life NA 5.154 hours 1compartment NA NA Rat Human +DTXSID8041452 Css NA 0.1424 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041452 Css NA 0.8827 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041452 Css NA 0.09092 mg/L PBTK NA 50% Rat Human +DTXSID8041452 Css NA 0.5402 mg/L PBTK NA 95% Rat Human +DTXSID80415219 Clint 19.05 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80415219 Fup 0.03 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80415219 Vd NA 1.203 L/kg 1compartment NA NA Human Human +DTXSID80415219 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80415219 TK.Half.Life NA 8.813 hours 1compartment NA NA Human Human +DTXSID80415219 Css NA 1.124 mg/L 3compartmentss NA 50% Human Human +DTXSID80415219 Css NA 9.962 mg/L 3compartmentss NA 95% Human Human +DTXSID80415219 Css NA 0.7011 mg/L PBTK NA 50% Human Human +DTXSID80415219 Css NA 6.037 mg/L PBTK NA 95% Human Human +DTXSID80415219 Clint 19.05 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80415219 Fup 0.03 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80415219 Vd NA 0.9003 L/kg 1compartment NA NA Rat Human +DTXSID80415219 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80415219 TK.Half.Life NA 3.689 hours 1compartment NA NA Rat Human +DTXSID80415219 Css NA 0.1474 mg/L 3compartmentss NA 50% Rat Human +DTXSID80415219 Css NA 1.05 mg/L 3compartmentss NA 95% Rat Human +DTXSID80415219 Css NA 0.08877 mg/L PBTK NA 50% Rat Human +DTXSID80415219 Css NA 0.6088 mg/L PBTK NA 95% Rat Human DTXSID8041610 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8041610 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041610 Vd NA 0.5748 L/kg 1compartment NA NA Human Human +DTXSID8041610 Vd NA 0.567 L/kg 1compartment NA NA Human Human DTXSID8041610 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041610 TK.Half.Life NA 3.721 hours 1compartment NA NA Human Human -DTXSID8041610 Css NA 0.8974 mg/L 3compartmentss NA 50% Human Human -DTXSID8041610 Css NA 5.642 mg/L 3compartmentss NA 95% Human Human -DTXSID8041610 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID8041610 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID8041610 TK.Half.Life NA 3.669 hours 1compartment NA NA Human Human +DTXSID8041610 Css NA 0.76 mg/L 3compartmentss NA 50% Human Human +DTXSID8041610 Css NA 5.195 mg/L 3compartmentss NA 95% Human Human +DTXSID8041610 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID8041610 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID8041610 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8041610 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041610 Vd NA 0.6152 L/kg 1compartment NA NA Rat Human +DTXSID8041610 Vd NA 0.6088 L/kg 1compartment NA NA Rat Human DTXSID8041610 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041610 TK.Half.Life NA 1.356 hours 1compartment NA NA Rat Human -DTXSID8041610 Css NA 0.2273 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041610 Css NA 1.364 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041610 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID8041610 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID8041743 Clint NA 12.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041743 Fup NA 0.0063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041743 Vd NA 2.933 L/kg 1compartment NA NA Human Human -DTXSID8041743 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID8041743 TK.Half.Life NA 130.2 hours 1compartment NA NA Human Human -DTXSID8041743 Css NA 5.985 mg/L 3compartmentss NA 50% Human Human -DTXSID8041743 Css NA 38.43 mg/L 3compartmentss NA 95% Human Human -DTXSID8041743 Css NA 4.063 mg/L PBTK NA 50% Human Human -DTXSID8041743 Css NA 25.3 mg/L PBTK NA 95% Human Human -DTXSID8041743 Clint NA 12.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041743 Fup NA 0.0063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041743 Vd NA 2.193 L/kg 1compartment NA NA Rat Human -DTXSID8041743 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID8041743 TK.Half.Life NA 21.69 hours 1compartment NA NA Rat Human -DTXSID8041743 Css NA 3.348 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041743 Css NA 18.23 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041743 Css NA 2.171 mg/L PBTK NA 50% Rat Human -DTXSID8041743 Css NA 11.44 mg/L PBTK NA 95% Rat Human -DTXSID8041745 Clint NA 17.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041745 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041745 Vd NA 2.133 L/kg 1compartment NA NA Human Human +DTXSID8041610 TK.Half.Life NA 1.342 hours 1compartment NA NA Rat Human +DTXSID8041610 Css NA 0.01399 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041610 Css NA 0.103 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041610 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID8041610 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID8041743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041743 Fup 0.0034 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041743 Vd NA 1.297 L/kg 1compartment NA NA Human Human +DTXSID8041743 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID8041743 TK.Half.Life NA 39.29 hours 1compartment NA NA Human Human +DTXSID8041743 Css NA 5.192 mg/L 3compartmentss NA 50% Human Human +DTXSID8041743 Css NA 40.44 mg/L 3compartmentss NA 95% Human Human +DTXSID8041743 Css NA 3.178 mg/L PBTK NA 50% Human Human +DTXSID8041743 Css NA 23.85 mg/L PBTK NA 95% Human Human +DTXSID8041743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041743 Fup 0.0034 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041743 Vd NA 0.9508 L/kg 1compartment NA NA Rat Human +DTXSID8041743 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8041743 TK.Half.Life NA 16.1 hours 1compartment NA NA Rat Human +DTXSID8041743 Css NA 0.6974 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041743 Css NA 4.442 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041743 Css NA 0.4112 mg/L PBTK NA 50% Rat Human +DTXSID8041743 Css NA 2.567 mg/L PBTK NA 95% Rat Human +DTXSID8041745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041745 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041745 Vd NA 2.119 L/kg 1compartment NA NA Human Human DTXSID8041745 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8041745 TK.Half.Life NA 19.44 hours 1compartment NA NA Human Human -DTXSID8041745 Css NA 1.322 mg/L 3compartmentss NA 50% Human Human -DTXSID8041745 Css NA 9.413 mg/L 3compartmentss NA 95% Human Human -DTXSID8041745 Css NA 0.8598 mg/L PBTK NA 50% Human Human -DTXSID8041745 Css NA 5.908 mg/L PBTK NA 95% Human Human -DTXSID8041745 Clint NA 17.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041745 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041745 Vd NA 1.593 L/kg 1compartment NA NA Rat Human -DTXSID8041745 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8041745 TK.Half.Life NA 5.914 hours 1compartment NA NA Rat Human -DTXSID8041745 Css NA 0.7384 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041745 Css NA 4.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041745 Css NA 0.455 mg/L PBTK NA 50% Rat Human -DTXSID8041745 Css NA 2.404 mg/L PBTK NA 95% Rat Human -DTXSID8041793 Clint NA 0.3847 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041793 Fup NA 0.0307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041793 Vd NA 0.2319 L/kg 1compartment NA NA Human Human -DTXSID8041793 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8041793 TK.Half.Life NA 29.76 hours 1compartment NA NA Human Human -DTXSID8041793 Css NA 21.99 mg/L 3compartmentss NA 50% Human Human -DTXSID8041793 Css NA 137.7 mg/L 3compartmentss NA 95% Human Human -DTXSID8041793 Css NA 13.02 mg/L PBTK NA 50% Human Human -DTXSID8041793 Css NA 80.14 mg/L PBTK NA 95% Human Human -DTXSID8041793 Clint NA 0.3847 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041793 Fup NA 0.0307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041793 Vd NA 0.2168 L/kg 1compartment NA NA Rat Human -DTXSID8041793 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8041793 TK.Half.Life NA 11.86 hours 1compartment NA NA Rat Human -DTXSID8041793 Css NA 7.898 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041793 Css NA 41.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041793 Css NA 4.363 mg/L PBTK NA 50% Rat Human -DTXSID8041793 Css NA 22.65 mg/L PBTK NA 95% Rat Human -DTXSID8041797 Clint NA 2.604 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041797 Fup NA 0.0057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041797 Vd NA 0.1729 L/kg 1compartment NA NA Human Human -DTXSID8041797 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID8041797 TK.Half.Life NA 37.01 hours 1compartment NA NA Human Human -DTXSID8041797 Css NA 39.3 mg/L 3compartmentss NA 50% Human Human -DTXSID8041797 Css NA 297.3 mg/L 3compartmentss NA 95% Human Human -DTXSID8041797 Css NA 23.04 mg/L PBTK NA 50% Human Human -DTXSID8041797 Css NA 171.2 mg/L PBTK NA 95% Human Human -DTXSID8041797 Clint NA 2.604 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041797 Fup NA 0.0057 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041797 Vd NA 0.1698 L/kg 1compartment NA NA Rat Human -DTXSID8041797 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID8041797 TK.Half.Life NA 21.24 hours 1compartment NA NA Rat Human -DTXSID8041797 Css NA 19.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041797 Css NA 118.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041797 Css NA 10.54 mg/L PBTK NA 50% Rat Human -DTXSID8041797 Css NA 64.16 mg/L PBTK NA 95% Rat Human -DTXSID8041799 Clint NA 5.986 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041799 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041799 Vd NA 0.1694 L/kg 1compartment NA NA Human Human -DTXSID8041799 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8041799 TK.Half.Life NA 30.36 hours 1compartment NA NA Human Human -DTXSID8041799 Css NA 34.45 mg/L 3compartmentss NA 50% Human Human -DTXSID8041799 Css NA 247.1 mg/L 3compartmentss NA 95% Human Human -DTXSID8041799 Css NA 19.99 mg/L PBTK NA 50% Human Human -DTXSID8041799 Css NA 143.2 mg/L PBTK NA 95% Human Human -DTXSID8041799 Clint NA 5.986 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041799 Fup NA 0.0033 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041799 Vd NA 0.1661 L/kg 1compartment NA NA Rat Human -DTXSID8041799 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8041799 TK.Half.Life NA 19.04 hours 1compartment NA NA Rat Human -DTXSID8041799 Css NA 18.17 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041799 Css NA 98.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041799 Css NA 9.839 mg/L PBTK NA 50% Rat Human -DTXSID8041799 Css NA 53.39 mg/L PBTK NA 95% Rat Human -DTXSID8041828 Clint NA 51.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041828 Fup NA 0.098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041828 Vd NA 0.7906 L/kg 1compartment NA NA Human Human +DTXSID8041745 TK.Half.Life NA 14.84 hours 1compartment NA NA Human Human +DTXSID8041745 Css NA 0.9644 mg/L 3compartmentss NA 50% Human Human +DTXSID8041745 Css NA 7.376 mg/L 3compartmentss NA 95% Human Human +DTXSID8041745 Css NA 0.6268 mg/L PBTK NA 50% Human Human +DTXSID8041745 Css NA 4.628 mg/L PBTK NA 95% Human Human +DTXSID8041745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041745 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041745 Vd NA 1.583 L/kg 1compartment NA NA Rat Human +DTXSID8041745 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8041745 TK.Half.Life NA 4.575 hours 1compartment NA NA Rat Human +DTXSID8041745 Css NA 0.1259 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041745 Css NA 0.7476 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041745 Css NA 0.0807 mg/L PBTK NA 50% Rat Human +DTXSID8041745 Css NA 0.4587 mg/L PBTK NA 95% Rat Human +DTXSID8041793 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041793 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041793 Vd NA 1.15 L/kg 1compartment NA NA Human Human +DTXSID8041793 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8041793 TK.Half.Life NA 2.308 hours 1compartment NA NA Human Human +DTXSID8041793 Css NA 0.1723 mg/L 3compartmentss NA 50% Human Human +DTXSID8041793 Css NA 1.316 mg/L 3compartmentss NA 95% Human Human +DTXSID8041793 Css NA 0.1167 mg/L PBTK NA 50% Human Human +DTXSID8041793 Css NA 0.847 mg/L PBTK NA 95% Human Human +DTXSID8041793 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041793 Fup 0.153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041793 Vd NA 0.9162 L/kg 1compartment NA NA Rat Human +DTXSID8041793 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8041793 TK.Half.Life NA 0.9776 hours 1compartment NA NA Rat Human +DTXSID8041793 Css NA 0.02186 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041793 Css NA 0.1326 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041793 Css NA 0.01459 mg/L PBTK NA 50% Rat Human +DTXSID8041793 Css NA 0.08314 mg/L PBTK NA 95% Rat Human +DTXSID8041797 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041797 Fup 0.0328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041797 Vd NA 0.8019 L/kg 1compartment NA NA Human Human +DTXSID8041797 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8041797 TK.Half.Life NA 4.77 hours 1compartment NA NA Human Human +DTXSID8041797 Css NA 0.9162 mg/L 3compartmentss NA 50% Human Human +DTXSID8041797 Css NA 8.81 mg/L 3compartmentss NA 95% Human Human +DTXSID8041797 Css NA 0.5614 mg/L PBTK NA 50% Human Human +DTXSID8041797 Css NA 5.241 mg/L PBTK NA 95% Human Human +DTXSID8041797 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041797 Fup 0.0328 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041797 Vd NA 0.6121 L/kg 1compartment NA NA Rat Human +DTXSID8041797 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8041797 TK.Half.Life NA 2.197 hours 1compartment NA NA Rat Human +DTXSID8041797 Css NA 0.121 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041797 Css NA 0.8391 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041797 Css NA 0.07154 mg/L PBTK NA 50% Rat Human +DTXSID8041797 Css NA 0.4806 mg/L PBTK NA 95% Rat Human +DTXSID8041799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041799 Fup 0.0489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041799 Vd NA 1.181 L/kg 1compartment NA NA Human Human +DTXSID8041799 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8041799 TK.Half.Life NA 5.336 hours 1compartment NA NA Human Human +DTXSID8041799 Css NA 0.6152 mg/L 3compartmentss NA 50% Human Human +DTXSID8041799 Css NA 4.921 mg/L 3compartmentss NA 95% Human Human +DTXSID8041799 Css NA 0.3864 mg/L PBTK NA 50% Human Human +DTXSID8041799 Css NA 2.934 mg/L PBTK NA 95% Human Human +DTXSID8041799 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041799 Fup 0.0489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041799 Vd NA 0.894 L/kg 1compartment NA NA Rat Human +DTXSID8041799 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8041799 TK.Half.Life NA 2.238 hours 1compartment NA NA Rat Human +DTXSID8041799 Css NA 0.08001 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041799 Css NA 0.5282 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041799 Css NA 0.04906 mg/L PBTK NA 50% Rat Human +DTXSID8041799 Css NA 0.3121 mg/L PBTK NA 95% Rat Human +DTXSID8041828 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041828 Fup 0.0859 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041828 Vd NA 1.482 L/kg 1compartment NA NA Human Human DTXSID8041828 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041828 TK.Half.Life NA 1.28 hours 1compartment NA NA Human Human -DTXSID8041828 Css NA 0.1266 mg/L 3compartmentss NA 50% Human Human -DTXSID8041828 Css NA 1.049 mg/L 3compartmentss NA 95% Human Human -DTXSID8041828 Css NA 0.0808 mg/L PBTK NA 50% Human Human -DTXSID8041828 Css NA 0.6411 mg/L PBTK NA 95% Human Human -DTXSID8041828 Clint NA 51.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041828 Fup NA 0.098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041828 Vd NA 0.6379 L/kg 1compartment NA NA Rat Human +DTXSID8041828 TK.Half.Life NA 4.677 hours 1compartment NA NA Human Human +DTXSID8041828 Css NA 0.3586 mg/L 3compartmentss NA 50% Human Human +DTXSID8041828 Css NA 2.745 mg/L 3compartmentss NA 95% Human Human +DTXSID8041828 Css NA 0.2343 mg/L PBTK NA 50% Human Human +DTXSID8041828 Css NA 1.7 mg/L PBTK NA 95% Human Human +DTXSID8041828 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041828 Fup 0.0859 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041828 Vd NA 1.13 L/kg 1compartment NA NA Rat Human DTXSID8041828 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041828 TK.Half.Life NA 0.5523 hours 1compartment NA NA Rat Human -DTXSID8041828 Css NA 0.0715 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041828 Css NA 0.4904 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041828 Css NA 0.04294 mg/L PBTK NA 50% Rat Human -DTXSID8041828 Css NA 0.2792 mg/L PBTK NA 95% Rat Human -DTXSID8041901 Clint NA 7.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041901 Fup NA 0.1501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041901 Vd NA 0.8469 L/kg 1compartment NA NA Human Human +DTXSID8041828 TK.Half.Life NA 1.819 hours 1compartment NA NA Rat Human +DTXSID8041828 Css NA 0.04673 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041828 Css NA 0.2769 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041828 Css NA 0.03006 mg/L PBTK NA 50% Rat Human +DTXSID8041828 Css NA 0.17 mg/L PBTK NA 95% Rat Human +DTXSID8041901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041901 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041901 Vd NA 1.054 L/kg 1compartment NA NA Human Human DTXSID8041901 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041901 TK.Half.Life NA 3.35 hours 1compartment NA NA Human Human -DTXSID8041901 Css NA 0.4762 mg/L 3compartmentss NA 50% Human Human -DTXSID8041901 Css NA 3.336 mg/L 3compartmentss NA 95% Human Human -DTXSID8041901 Css NA 0.3181 mg/L PBTK NA 50% Human Human -DTXSID8041901 Css NA 2.064 mg/L PBTK NA 95% Human Human -DTXSID8041901 Clint NA 7.616 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041901 Fup NA 0.1501 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041901 Vd NA 0.6996 L/kg 1compartment NA NA Rat Human +DTXSID8041901 TK.Half.Life NA 1.643 hours 1compartment NA NA Human Human +DTXSID8041901 Css NA 0.09765 mg/L 3compartmentss NA 50% Human Human +DTXSID8041901 Css NA 0.6752 mg/L 3compartmentss NA 95% Human Human +DTXSID8041901 Css NA 0.06951 mg/L PBTK NA 50% Human Human +DTXSID8041901 Css NA 0.4488 mg/L PBTK NA 95% Human Human +DTXSID8041901 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041901 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041901 Vd NA 0.8729 L/kg 1compartment NA NA Rat Human DTXSID8041901 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041901 TK.Half.Life NA 1.587 hours 1compartment NA NA Rat Human -DTXSID8041901 Css NA 0.2531 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041901 Css NA 1.319 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041901 Css NA 0.1588 mg/L PBTK NA 50% Rat Human -DTXSID8041901 Css NA 0.7729 mg/L PBTK NA 95% Rat Human -DTXSID8041909 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041909 Fup NA 0.4088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041909 Vd NA 2.894 L/kg 1compartment NA NA Human Human -DTXSID8041909 Days.Css NA 58 Days PBTK NA NA Human Human -DTXSID8041909 TK.Half.Life NA 267.5 hours 1compartment NA NA Human Human -DTXSID8041909 Css NA 9.996 mg/L 3compartmentss NA 50% Human Human -DTXSID8041909 Css NA 29.17 mg/L 3compartmentss NA 95% Human Human -DTXSID8041909 Css NA 7.508 mg/L PBTK NA 50% Human Human -DTXSID8041909 Css NA 19.58 mg/L PBTK NA 95% Human Human -DTXSID8041909 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041909 Fup NA 0.4088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041909 Vd NA 2.208 L/kg 1compartment NA NA Rat Human -DTXSID8041909 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID8041909 TK.Half.Life NA 25.65 hours 1compartment NA NA Rat Human -DTXSID8041909 Css NA 2.684 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041909 Css NA 6.383 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041909 Css NA 1.945 mg/L PBTK NA 50% Rat Human -DTXSID8041909 Css NA 4.017 mg/L PBTK NA 95% Rat Human -DTXSID8041951 Clint NA 1.602 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041951 Fup NA 0.1065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041951 Vd NA 1.856 L/kg 1compartment NA NA Human Human -DTXSID8041951 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID8041951 TK.Half.Life NA 44.69 hours 1compartment NA NA Human Human -DTXSID8041951 Css NA 3.416 mg/L 3compartmentss NA 50% Human Human -DTXSID8041951 Css NA 15.79 mg/L 3compartmentss NA 95% Human Human -DTXSID8041951 Css NA 2.31 mg/L PBTK NA 50% Human Human -DTXSID8041951 Css NA 9.946 mg/L PBTK NA 95% Human Human -DTXSID8041951 Clint NA 1.602 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041951 Fup NA 0.1065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041951 Vd NA 1.411 L/kg 1compartment NA NA Rat Human -DTXSID8041951 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8041951 TK.Half.Life NA 13.19 hours 1compartment NA NA Rat Human -DTXSID8041951 Css NA 1.536 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041951 Css NA 5.658 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041951 Css NA 0.9863 mg/L PBTK NA 50% Rat Human -DTXSID8041951 Css NA 3.261 mg/L PBTK NA 95% Rat Human +DTXSID8041901 TK.Half.Life NA 0.7153 hours 1compartment NA NA Rat Human +DTXSID8041901 Css NA 0.01228 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041901 Css NA 0.06586 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041901 Css NA 0.008704 mg/L PBTK NA 50% Rat Human +DTXSID8041901 Css NA 0.04371 mg/L PBTK NA 95% Rat Human +DTXSID8041951 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041951 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041951 Vd NA 2.201 L/kg 1compartment NA NA Human Human +DTXSID8041951 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8041951 TK.Half.Life NA 6.944 hours 1compartment NA NA Human Human +DTXSID8041951 Css NA 0.3266 mg/L 3compartmentss NA 50% Human Human +DTXSID8041951 Css NA 2.217 mg/L 3compartmentss NA 95% Human Human +DTXSID8041951 Css NA 0.2252 mg/L PBTK NA 50% Human Human +DTXSID8041951 Css NA 1.458 mg/L PBTK NA 95% Human Human +DTXSID8041951 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041951 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041951 Vd NA 1.669 L/kg 1compartment NA NA Rat Human +DTXSID8041951 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8041951 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human +DTXSID8041951 Css NA 0.04214 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041951 Css NA 0.2311 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041951 Css NA 0.02858 mg/L PBTK NA 50% Rat Human +DTXSID8041951 Css NA 0.1493 mg/L PBTK NA 95% Rat Human DTXSID8041955 Clint NA 0.1474 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8041955 Fup NA 0.871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041955 Vd NA 2.019 L/kg 1compartment NA NA Human Human +DTXSID8041955 Vd NA 1.968 L/kg 1compartment NA NA Human Human DTXSID8041955 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8041955 TK.Half.Life NA 12.09 hours 1compartment NA NA Human Human -DTXSID8041955 Css NA 0.6008 mg/L 3compartmentss NA 50% Human Human -DTXSID8041955 Css NA 4.132 mg/L 3compartmentss NA 95% Human Human -DTXSID8041955 Css NA 0.6162 mg/L PBTK NA 50% Human Human -DTXSID8041955 Css NA 2.83 mg/L PBTK NA 95% Human Human +DTXSID8041955 TK.Half.Life NA 11.79 hours 1compartment NA NA Human Human +DTXSID8041955 Css NA 0.5175 mg/L 3compartmentss NA 50% Human Human +DTXSID8041955 Css NA 3.435 mg/L 3compartmentss NA 95% Human Human +DTXSID8041955 Css NA 0.5216 mg/L PBTK NA 50% Human Human +DTXSID8041955 Css NA 2.427 mg/L PBTK NA 95% Human Human DTXSID8041955 Clint NA 0.1474 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8041955 Fup NA 0.871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041955 Vd NA 2.056 L/kg 1compartment NA NA Rat Human +DTXSID8041955 Vd NA 2.004 L/kg 1compartment NA NA Rat Human DTXSID8041955 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041955 TK.Half.Life NA 4.658 hours 1compartment NA NA Rat Human -DTXSID8041955 Css NA 0.1689 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041955 Css NA 1.169 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041955 Css NA 0.1715 mg/L PBTK NA 50% Rat Human -DTXSID8041955 Css NA 0.7558 mg/L PBTK NA 95% Rat Human -DTXSID8041957 Clint NA 12.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041957 Fup NA 0.6403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8041957 Vd NA 1.174 L/kg 1compartment NA NA Human Human -DTXSID8041957 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8041957 TK.Half.Life NA 1.203 hours 1compartment NA NA Human Human -DTXSID8041957 Css NA 0.05426 mg/L 3compartmentss NA 50% Human Human -DTXSID8041957 Css NA 0.581 mg/L 3compartmentss NA 95% Human Human -DTXSID8041957 Css NA 0.04597 mg/L PBTK NA 50% Human Human -DTXSID8041957 Css NA 0.3972 mg/L PBTK NA 95% Human Human -DTXSID8041957 Clint NA 12.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041957 Fup NA 0.6403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8041957 Vd NA 1.071 L/kg 1compartment NA NA Rat Human +DTXSID8041955 TK.Half.Life NA 4.542 hours 1compartment NA NA Rat Human +DTXSID8041955 Css NA 0.01095 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041955 Css NA 0.08652 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041955 Css NA 0.01074 mg/L PBTK NA 50% Rat Human +DTXSID8041955 Css NA 0.06417 mg/L PBTK NA 95% Rat Human +DTXSID8041957 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041957 Fup 0.52 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8041957 Vd NA 1.04 L/kg 1compartment NA NA Human Human +DTXSID8041957 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8041957 TK.Half.Life NA 13.72 hours 1compartment NA NA Human Human +DTXSID8041957 Css NA 1.34 mg/L 3compartmentss NA 50% Human Human +DTXSID8041957 Css NA 7.314 mg/L 3compartmentss NA 95% Human Human +DTXSID8041957 Css NA 1.108 mg/L PBTK NA 50% Human Human +DTXSID8041957 Css NA 4.715 mg/L PBTK NA 95% Human Human +DTXSID8041957 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041957 Fup 0.52 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8041957 Vd NA 0.9463 L/kg 1compartment NA NA Rat Human DTXSID8041957 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8041957 TK.Half.Life NA 0.5559 hours 1compartment NA NA Rat Human -DTXSID8041957 Css NA 0.02725 mg/L 3compartmentss NA 50% Rat Human -DTXSID8041957 Css NA 0.236 mg/L 3compartmentss NA 95% Rat Human -DTXSID8041957 Css NA 0.0229 mg/L PBTK NA 50% Rat Human -DTXSID8041957 Css NA 0.1521 mg/L PBTK NA 95% Rat Human -DTXSID8042002 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042002 Fup NA 0.7018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042002 Vd NA 0.449 L/kg 1compartment NA NA Human Human +DTXSID8041957 TK.Half.Life NA 4.07 hours 1compartment NA NA Rat Human +DTXSID8041957 Css NA 0.08318 mg/L 3compartmentss NA 50% Rat Human +DTXSID8041957 Css NA 0.4236 mg/L 3compartmentss NA 95% Rat Human +DTXSID8041957 Css NA 0.0684 mg/L PBTK NA 50% Rat Human +DTXSID8041957 Css NA 0.2658 mg/L PBTK NA 95% Rat Human +DTXSID8042002 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042002 Fup 0.676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042002 Vd NA 0.4395 L/kg 1compartment NA NA Human Human DTXSID8042002 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042002 TK.Half.Life NA 4.141 hours 1compartment NA NA Human Human -DTXSID8042002 Css NA 1.198 mg/L 3compartmentss NA 50% Human Human -DTXSID8042002 Css NA 7.179 mg/L 3compartmentss NA 95% Human Human -DTXSID8042002 Css NA 0.8754 mg/L PBTK NA 50% Human Human -DTXSID8042002 Css NA 4.445 mg/L PBTK NA 95% Human Human -DTXSID8042002 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042002 Fup NA 0.7018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042002 Vd NA 0.4685 L/kg 1compartment NA NA Rat Human +DTXSID8042002 TK.Half.Life NA 4.206 hours 1compartment NA NA Human Human +DTXSID8042002 Css NA 1.069 mg/L 3compartmentss NA 50% Human Human +DTXSID8042002 Css NA 6.675 mg/L 3compartmentss NA 95% Human Human +DTXSID8042002 Css NA 0.7751 mg/L PBTK NA 50% Human Human +DTXSID8042002 Css NA 4.104 mg/L PBTK NA 95% Human Human +DTXSID8042002 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042002 Fup 0.676 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042002 Vd NA 0.4585 L/kg 1compartment NA NA Rat Human DTXSID8042002 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042002 TK.Half.Life NA 1.472 hours 1compartment NA NA Rat Human -DTXSID8042002 Css NA 0.3194 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042002 Css NA 1.877 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042002 Css NA 0.2223 mg/L PBTK NA 50% Rat Human -DTXSID8042002 Css NA 1.074 mg/L PBTK NA 95% Rat Human -DTXSID8042006 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042006 Fup NA 0.4043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042006 Vd NA 1.11 L/kg 1compartment NA NA Human Human -DTXSID8042006 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8042006 TK.Half.Life NA 19.5 hours 1compartment NA NA Human Human -DTXSID8042006 Css NA 1.871 mg/L 3compartmentss NA 50% Human Human -DTXSID8042006 Css NA 7.954 mg/L 3compartmentss NA 95% Human Human -DTXSID8042006 Css NA 1.47 mg/L PBTK NA 50% Human Human -DTXSID8042006 Css NA 5.288 mg/L PBTK NA 95% Human Human -DTXSID8042006 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042006 Fup NA 0.4043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042006 Vd NA 0.9666 L/kg 1compartment NA NA Rat Human -DTXSID8042006 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042006 TK.Half.Life NA 5.394 hours 1compartment NA NA Rat Human -DTXSID8042006 Css NA 0.5019 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042006 Css NA 1.902 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042006 Css NA 0.3812 mg/L PBTK NA 50% Rat Human -DTXSID8042006 Css NA 1.164 mg/L PBTK NA 95% Rat Human -DTXSID8042137 Clint NA 10.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042137 Fup NA 0.0769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042137 Vd NA 1.409 L/kg 1compartment NA NA Human Human +DTXSID8042002 TK.Half.Life NA 1.495 hours 1compartment NA NA Rat Human +DTXSID8042002 Css NA 0.02781 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042002 Css NA 0.2007 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042002 Css NA 0.01957 mg/L PBTK NA 50% Rat Human +DTXSID8042002 Css NA 0.1207 mg/L PBTK NA 95% Rat Human +DTXSID8042137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042137 Fup 0.0807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042137 Vd NA 1.298 L/kg 1compartment NA NA Human Human DTXSID8042137 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042137 TK.Half.Life NA 8.582 hours 1compartment NA NA Human Human -DTXSID8042137 Css NA 0.861 mg/L 3compartmentss NA 50% Human Human -DTXSID8042137 Css NA 5.913 mg/L 3compartmentss NA 95% Human Human -DTXSID8042137 Css NA 0.5583 mg/L PBTK NA 50% Human Human -DTXSID8042137 Css NA 3.635 mg/L PBTK NA 95% Human Human -DTXSID8042137 Clint NA 10.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042137 Fup NA 0.0769 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042137 Vd NA 1.073 L/kg 1compartment NA NA Rat Human +DTXSID8042137 TK.Half.Life NA 4.133 hours 1compartment NA NA Human Human +DTXSID8042137 Css NA 0.3685 mg/L 3compartmentss NA 50% Human Human +DTXSID8042137 Css NA 2.861 mg/L 3compartmentss NA 95% Human Human +DTXSID8042137 Css NA 0.2398 mg/L PBTK NA 50% Human Human +DTXSID8042137 Css NA 1.783 mg/L PBTK NA 95% Human Human +DTXSID8042137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042137 Fup 0.0807 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042137 Vd NA 0.9937 L/kg 1compartment NA NA Rat Human DTXSID8042137 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042137 TK.Half.Life NA 3.409 hours 1compartment NA NA Rat Human -DTXSID8042137 Css NA 0.466 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042137 Css NA 2.409 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042137 Css NA 0.2852 mg/L PBTK NA 50% Rat Human -DTXSID8042137 Css NA 1.405 mg/L PBTK NA 95% Rat Human -DTXSID8042181 Clint NA 4.977 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042181 Fup NA 0.2043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042181 Vd NA 1.945 L/kg 1compartment NA NA Human Human +DTXSID8042137 TK.Half.Life NA 1.685 hours 1compartment NA NA Rat Human +DTXSID8042137 Css NA 0.04828 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042137 Css NA 0.2839 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042137 Css NA 0.03048 mg/L PBTK NA 50% Rat Human +DTXSID8042137 Css NA 0.1726 mg/L PBTK NA 95% Rat Human +DTXSID8042181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042181 Fup 0.0769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042181 Vd NA 1.268 L/kg 1compartment NA NA Human Human DTXSID8042181 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042181 TK.Half.Life NA 11 hours 1compartment NA NA Human Human -DTXSID8042181 Css NA 0.608 mg/L 3compartmentss NA 50% Human Human -DTXSID8042181 Css NA 3.178 mg/L 3compartmentss NA 95% Human Human -DTXSID8042181 Css NA 0.4401 mg/L PBTK NA 50% Human Human -DTXSID8042181 Css NA 2.14 mg/L PBTK NA 95% Human Human -DTXSID8042181 Clint NA 4.977 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042181 Fup NA 0.2043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042181 Vd NA 1.504 L/kg 1compartment NA NA Rat Human +DTXSID8042181 TK.Half.Life NA 4.161 hours 1compartment NA NA Human Human +DTXSID8042181 Css NA 0.389 mg/L 3compartmentss NA 50% Human Human +DTXSID8042181 Css NA 2.843 mg/L 3compartmentss NA 95% Human Human +DTXSID8042181 Css NA 0.252 mg/L PBTK NA 50% Human Human +DTXSID8042181 Css NA 1.777 mg/L PBTK NA 95% Human Human +DTXSID8042181 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042181 Fup 0.0769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042181 Vd NA 0.9705 L/kg 1compartment NA NA Rat Human DTXSID8042181 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042181 TK.Half.Life NA 3.66 hours 1compartment NA NA Rat Human -DTXSID8042181 Css NA 0.306 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042181 Css NA 1.145 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042181 Css NA 0.213 mg/L PBTK NA 50% Rat Human -DTXSID8042181 Css NA 0.7345 mg/L PBTK NA 95% Rat Human -DTXSID8042187 Clint NA 27.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042187 Fup NA 0.3484 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042187 Vd NA 2.559 L/kg 1compartment NA NA Human Human +DTXSID8042181 TK.Half.Life NA 1.708 hours 1compartment NA NA Rat Human +DTXSID8042181 Css NA 0.05048 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042181 Css NA 0.297 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042181 Css NA 0.03182 mg/L PBTK NA 50% Rat Human +DTXSID8042181 Css NA 0.1797 mg/L PBTK NA 95% Rat Human +DTXSID8042187 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042187 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042187 Vd NA 2.149 L/kg 1compartment NA NA Human Human DTXSID8042187 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042187 TK.Half.Life NA 3.644 hours 1compartment NA NA Human Human -DTXSID8042187 Css NA 0.085 mg/L 3compartmentss NA 50% Human Human -DTXSID8042187 Css NA 0.5643 mg/L 3compartmentss NA 95% Human Human -DTXSID8042187 Css NA 0.0674 mg/L PBTK NA 50% Human Human -DTXSID8042187 Css NA 0.4206 mg/L PBTK NA 95% Human Human -DTXSID8042187 Clint NA 27.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042187 Fup NA 0.3484 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042187 Vd NA 2.049 L/kg 1compartment NA NA Rat Human +DTXSID8042187 TK.Half.Life NA 4.237 hours 1compartment NA NA Human Human +DTXSID8042187 Css NA 0.1414 mg/L 3compartmentss NA 50% Human Human +DTXSID8042187 Css NA 0.9374 mg/L 3compartmentss NA 95% Human Human +DTXSID8042187 Css NA 0.106 mg/L PBTK NA 50% Human Human +DTXSID8042187 Css NA 0.6693 mg/L PBTK NA 95% Human Human +DTXSID8042187 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042187 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042187 Vd NA 1.711 L/kg 1compartment NA NA Rat Human DTXSID8042187 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042187 TK.Half.Life NA 1.182 hours 1compartment NA NA Rat Human -DTXSID8042187 Css NA 0.0458 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042187 Css NA 0.2379 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042187 Css NA 0.03553 mg/L PBTK NA 50% Rat Human -DTXSID8042187 Css NA 0.1689 mg/L PBTK NA 95% Rat Human +DTXSID8042187 TK.Half.Life NA 1.499 hours 1compartment NA NA Rat Human +DTXSID8042187 Css NA 0.01797 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042187 Css NA 0.0933 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042187 Css NA 0.01337 mg/L PBTK NA 50% Rat Human +DTXSID8042187 Css NA 0.06468 mg/L PBTK NA 95% Rat Human DTXSID8042210 Clint NA 0.3653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8042210 Fup NA 0.699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8042210 Vd NA 1.862 L/kg 1compartment NA NA Human Human DTXSID8042210 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID8042210 TK.Half.Life NA 10.82 hours 1compartment NA NA Human Human -DTXSID8042210 Css NA 0.528 mg/L 3compartmentss NA 50% Human Human -DTXSID8042210 Css NA 4.038 mg/L 3compartmentss NA 95% Human Human -DTXSID8042210 Css NA 0.5352 mg/L PBTK NA 50% Human Human -DTXSID8042210 Css NA 2.825 mg/L PBTK NA 95% Human Human +DTXSID8042210 Css NA 0.4451 mg/L 3compartmentss NA 50% Human Human +DTXSID8042210 Css NA 3.439 mg/L 3compartmentss NA 95% Human Human +DTXSID8042210 Css NA 0.4585 mg/L PBTK NA 50% Human Human +DTXSID8042210 Css NA 2.366 mg/L PBTK NA 95% Human Human DTXSID8042210 Clint NA 0.3653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8042210 Fup NA 0.699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8042210 Vd NA 1.842 L/kg 1compartment NA NA Rat Human DTXSID8042210 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8042210 TK.Half.Life NA 4.498 hours 1compartment NA NA Rat Human -DTXSID8042210 Css NA 0.1683 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042210 Css NA 1.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042210 Css NA 0.1697 mg/L PBTK NA 50% Rat Human -DTXSID8042210 Css NA 0.8488 mg/L PBTK NA 95% Rat Human -DTXSID8042264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042264 Fup NA 0.2589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042264 Vd NA 1.387 L/kg 1compartment NA NA Human Human -DTXSID8042264 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID8042264 TK.Half.Life NA 43.08 hours 1compartment NA NA Human Human -DTXSID8042264 Css NA 3.428 mg/L 3compartmentss NA 50% Human Human -DTXSID8042264 Css NA 12.67 mg/L 3compartmentss NA 95% Human Human -DTXSID8042264 Css NA 2.543 mg/L PBTK NA 50% Human Human -DTXSID8042264 Css NA 8.17 mg/L PBTK NA 95% Human Human -DTXSID8042264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042264 Fup NA 0.2589 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042264 Vd NA 1.12 L/kg 1compartment NA NA Rat Human -DTXSID8042264 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8042264 TK.Half.Life NA 10.09 hours 1compartment NA NA Rat Human -DTXSID8042264 Css NA 0.9412 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042264 Css NA 2.821 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042264 Css NA 0.6684 mg/L PBTK NA 50% Rat Human -DTXSID8042264 Css NA 1.711 mg/L PBTK NA 95% Rat Human -DTXSID8042349 Clint NA 96.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042349 Fup NA 0.011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042349 Vd NA 3.086 L/kg 1compartment NA NA Human Human -DTXSID8042349 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8042349 TK.Half.Life NA 21.55 hours 1compartment NA NA Human Human -DTXSID8042349 Css NA 0.7817 mg/L 3compartmentss NA 50% Human Human -DTXSID8042349 Css NA 4.88 mg/L 3compartmentss NA 95% Human Human -DTXSID8042349 Css NA 0.5396 mg/L PBTK NA 50% Human Human -DTXSID8042349 Css NA 3.307 mg/L PBTK NA 95% Human Human -DTXSID8042349 Clint NA 96.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042349 Fup NA 0.011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042349 Vd NA 2.31 L/kg 1compartment NA NA Rat Human -DTXSID8042349 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8042349 TK.Half.Life NA 3.409 hours 1compartment NA NA Rat Human -DTXSID8042349 Css NA 0.4394 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042349 Css NA 2.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042349 Css NA 0.2908 mg/L PBTK NA 50% Rat Human -DTXSID8042349 Css NA 1.37 mg/L PBTK NA 95% Rat Human -DTXSID8042399 Clint NA 2.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042399 Fup NA 0.0184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042399 Vd NA 0.6934 L/kg 1compartment NA NA Human Human -DTXSID8042399 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID8042399 TK.Half.Life NA 44.95 hours 1compartment NA NA Human Human -DTXSID8042399 Css NA 11.57 mg/L 3compartmentss NA 50% Human Human -DTXSID8042399 Css NA 85.6 mg/L 3compartmentss NA 95% Human Human -DTXSID8042399 Css NA 6.978 mg/L PBTK NA 50% Human Human -DTXSID8042399 Css NA 50.06 mg/L PBTK NA 95% Human Human -DTXSID8042399 Clint NA 2.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042399 Fup NA 0.0184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042399 Vd NA 0.5237 L/kg 1compartment NA NA Rat Human -DTXSID8042399 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8042399 TK.Half.Life NA 18.96 hours 1compartment NA NA Rat Human -DTXSID8042399 Css NA 5.645 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042399 Css NA 34.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042399 Css NA 3.171 mg/L PBTK NA 50% Rat Human -DTXSID8042399 Css NA 18.52 mg/L PBTK NA 95% Rat Human -DTXSID8042422 Clint NA 6.594 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042422 Fup NA 0.7636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042422 Vd NA 1.078 L/kg 1compartment NA NA Human Human +DTXSID8042210 Css NA 0.01048 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042210 Css NA 0.1067 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042210 Css NA 0.01037 mg/L PBTK NA 50% Rat Human +DTXSID8042210 Css NA 0.07414 mg/L PBTK NA 95% Rat Human +DTXSID8042260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042260 Fup 0.0464 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042260 Vd NA 2.371 L/kg 1compartment NA NA Human Human +DTXSID8042260 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8042260 TK.Half.Life NA 16.24 hours 1compartment NA NA Human Human +DTXSID8042260 Css NA 0.8718 mg/L 3compartmentss NA 50% Human Human +DTXSID8042260 Css NA 6.068 mg/L 3compartmentss NA 95% Human Human +DTXSID8042260 Css NA 0.5827 mg/L PBTK NA 50% Human Human +DTXSID8042260 Css NA 3.812 mg/L PBTK NA 95% Human Human +DTXSID8042260 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042260 Fup 0.0464 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042260 Vd NA 1.775 L/kg 1compartment NA NA Rat Human +DTXSID8042260 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8042260 TK.Half.Life NA 4.432 hours 1compartment NA NA Rat Human +DTXSID8042260 Css NA 0.112 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042260 Css NA 0.6068 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042260 Css NA 0.07348 mg/L PBTK NA 50% Rat Human +DTXSID8042260 Css NA 0.3915 mg/L PBTK NA 95% Rat Human +DTXSID8042264 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042264 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042264 Vd NA 1.338 L/kg 1compartment NA NA Human Human +DTXSID8042264 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8042264 TK.Half.Life NA 2.062 hours 1compartment NA NA Human Human +DTXSID8042264 Css NA 0.09537 mg/L 3compartmentss NA 50% Human Human +DTXSID8042264 Css NA 0.6807 mg/L 3compartmentss NA 95% Human Human +DTXSID8042264 Css NA 0.06926 mg/L PBTK NA 50% Human Human +DTXSID8042264 Css NA 0.4509 mg/L PBTK NA 95% Human Human +DTXSID8042264 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042264 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042264 Vd NA 1.08 L/kg 1compartment NA NA Rat Human +DTXSID8042264 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8042264 TK.Half.Life NA 0.8421 hours 1compartment NA NA Rat Human +DTXSID8042264 Css NA 0.01189 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042264 Css NA 0.06272 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042264 Css NA 0.00868 mg/L PBTK NA 50% Rat Human +DTXSID8042264 Css NA 0.04314 mg/L PBTK NA 95% Rat Human +DTXSID8042349 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042349 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042349 Vd NA 3.096 L/kg 1compartment NA NA Human Human +DTXSID8042349 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID8042349 TK.Half.Life NA 86.6 hours 1compartment NA NA Human Human +DTXSID8042349 Css NA 3.342 mg/L 3compartmentss NA 50% Human Human +DTXSID8042349 Css NA 21.99 mg/L 3compartmentss NA 95% Human Human +DTXSID8042349 Css NA 2.325 mg/L PBTK NA 50% Human Human +DTXSID8042349 Css NA 14.76 mg/L PBTK NA 95% Human Human +DTXSID8042349 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042349 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042349 Vd NA 2.319 L/kg 1compartment NA NA Rat Human +DTXSID8042349 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID8042349 TK.Half.Life NA 12.04 hours 1compartment NA NA Rat Human +DTXSID8042349 Css NA 0.4354 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042349 Css NA 2.284 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042349 Css NA 0.2987 mg/L PBTK NA 50% Rat Human +DTXSID8042349 Css NA 1.565 mg/L PBTK NA 95% Rat Human +DTXSID8042399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042399 Fup 0.0279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042399 Vd NA 1.838 L/kg 1compartment NA NA Human Human +DTXSID8042399 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8042399 TK.Half.Life NA 14.32 hours 1compartment NA NA Human Human +DTXSID8042399 Css NA 1.135 mg/L 3compartmentss NA 50% Human Human +DTXSID8042399 Css NA 9.104 mg/L 3compartmentss NA 95% Human Human +DTXSID8042399 Css NA 0.7312 mg/L PBTK NA 50% Human Human +DTXSID8042399 Css NA 5.616 mg/L PBTK NA 95% Human Human +DTXSID8042399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042399 Fup 0.0279 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042399 Vd NA 1.368 L/kg 1compartment NA NA Rat Human +DTXSID8042399 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8042399 TK.Half.Life NA 4.909 hours 1compartment NA NA Rat Human +DTXSID8042399 Css NA 0.1459 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042399 Css NA 0.9746 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042399 Css NA 0.09192 mg/L PBTK NA 50% Rat Human +DTXSID8042399 Css NA 0.5816 mg/L PBTK NA 95% Rat Human +DTXSID8042422 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042422 Fup 0.456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042422 Vd NA 0.8251 L/kg 1compartment NA NA Human Human DTXSID8042422 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042422 TK.Half.Life NA 1.306 hours 1compartment NA NA Human Human -DTXSID8042422 Css NA 0.08712 mg/L 3compartmentss NA 50% Human Human -DTXSID8042422 Css NA 0.7369 mg/L 3compartmentss NA 95% Human Human -DTXSID8042422 Css NA 0.07546 mg/L PBTK NA 50% Human Human -DTXSID8042422 Css NA 0.5185 mg/L PBTK NA 95% Human Human -DTXSID8042422 Clint NA 6.594 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042422 Fup NA 0.7636 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042422 Vd NA 1.026 L/kg 1compartment NA NA Rat Human +DTXSID8042422 TK.Half.Life NA 0.855 hours 1compartment NA NA Human Human +DTXSID8042422 Css NA 0.04172 mg/L 3compartmentss NA 50% Human Human +DTXSID8042422 Css NA 0.369 mg/L 3compartmentss NA 95% Human Human +DTXSID8042422 Css NA 0.03234 mg/L PBTK NA 50% Human Human +DTXSID8042422 Css NA 0.2503 mg/L PBTK NA 95% Human Human +DTXSID8042422 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042422 Fup 0.456 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042422 Vd NA 0.775 L/kg 1compartment NA NA Rat Human DTXSID8042422 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042422 TK.Half.Life NA 0.6502 hours 1compartment NA NA Rat Human -DTXSID8042422 Css NA 0.04226 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042422 Css NA 0.3374 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042422 Css NA 0.03604 mg/L PBTK NA 50% Rat Human -DTXSID8042422 Css NA 0.2113 mg/L PBTK NA 95% Rat Human +DTXSID8042422 TK.Half.Life NA 0.4073 hours 1compartment NA NA Rat Human +DTXSID8042422 Css NA 0.005136 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042422 Css NA 0.03457 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042422 Css NA 0.004028 mg/L PBTK NA 50% Rat Human +DTXSID8042422 Css NA 0.0236 mg/L PBTK NA 95% Rat Human DTXSID8042424 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8042424 Fup 0.0037 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8042424 Vd NA 0.1921 L/kg 1compartment NA NA Human Human DTXSID8042424 Days.Css NA 84 Days PBTK NA NA Human Human DTXSID8042424 TK.Half.Life NA 336.3 hours 1compartment NA NA Human Human -DTXSID8042424 Css NA 144.7 mg/L 3compartmentss NA 50% Human Human -DTXSID8042424 Css NA 544.2 mg/L 3compartmentss NA 95% Human Human -DTXSID8042424 Css NA 84.06 mg/L PBTK NA 50% Human Human -DTXSID8042424 Css NA 313.4 mg/L PBTK NA 95% Human Human +DTXSID8042424 Css NA 139.4 mg/L 3compartmentss NA 50% Human Human +DTXSID8042424 Css NA 522.2 mg/L 3compartmentss NA 95% Human Human +DTXSID8042424 Css NA 81.29 mg/L PBTK NA 50% Human Human +DTXSID8042424 Css NA 300 mg/L PBTK NA 95% Human Human DTXSID8042424 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8042424 Fup 0.0037 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8042424 Vd NA 0.1788 L/kg 1compartment NA NA Rat Human DTXSID8042424 Days.Css NA 23 Days PBTK NA NA Rat Human DTXSID8042424 TK.Half.Life NA 106.6 hours 1compartment NA NA Rat Human -DTXSID8042424 Css NA 41.18 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042424 Css NA 123.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042424 Css NA 22.4 mg/L PBTK NA 50% Rat Human -DTXSID8042424 Css NA 67.04 mg/L PBTK NA 95% Rat Human +DTXSID8042424 Css NA 9.06 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042424 Css NA 26.99 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042424 Css NA 5.101 mg/L PBTK NA 50% Rat Human +DTXSID8042424 Css NA 15.12 mg/L PBTK NA 95% Rat Human DTXSID8042426 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8042426 Fup NA 0.824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042426 Vd NA 0.7555 L/kg 1compartment NA NA Human Human +DTXSID8042426 Vd NA 0.6867 L/kg 1compartment NA NA Human Human DTXSID8042426 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042426 TK.Half.Life NA 5.934 hours 1compartment NA NA Human Human -DTXSID8042426 Css NA 0.9568 mg/L 3compartmentss NA 50% Human Human -DTXSID8042426 Css NA 5.773 mg/L 3compartmentss NA 95% Human Human -DTXSID8042426 Css NA 0.8016 mg/L PBTK NA 50% Human Human -DTXSID8042426 Css NA 3.727 mg/L PBTK NA 95% Human Human +DTXSID8042426 TK.Half.Life NA 5.39 hours 1compartment NA NA Human Human +DTXSID8042426 Css NA 0.8417 mg/L 3compartmentss NA 50% Human Human +DTXSID8042426 Css NA 5.002 mg/L 3compartmentss NA 95% Human Human +DTXSID8042426 Css NA 0.6912 mg/L PBTK NA 50% Human Human +DTXSID8042426 Css NA 3.258 mg/L PBTK NA 95% Human Human DTXSID8042426 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8042426 Fup NA 0.824 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042426 Vd NA 0.7842 L/kg 1compartment NA NA Rat Human +DTXSID8042426 Vd NA 0.7222 L/kg 1compartment NA NA Rat Human DTXSID8042426 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042426 TK.Half.Life NA 2.099 hours 1compartment NA NA Rat Human -DTXSID8042426 Css NA 0.2464 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042426 Css NA 1.483 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042426 Css NA 0.2001 mg/L PBTK NA 50% Rat Human -DTXSID8042426 Css NA 0.8914 mg/L PBTK NA 95% Rat Human -DTXSID8042478 Clint NA 14.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042478 Fup NA 0.0179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042478 Vd NA 2.046 L/kg 1compartment NA NA Human Human -DTXSID8042478 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8042478 TK.Half.Life NA 32.59 hours 1compartment NA NA Human Human -DTXSID8042478 Css NA 2.491 mg/L 3compartmentss NA 50% Human Human -DTXSID8042478 Css NA 19.66 mg/L 3compartmentss NA 95% Human Human -DTXSID8042478 Css NA 1.602 mg/L PBTK NA 50% Human Human -DTXSID8042478 Css NA 11.98 mg/L PBTK NA 95% Human Human -DTXSID8042478 Clint NA 14.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042478 Fup NA 0.0179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042478 Vd NA 1.521 L/kg 1compartment NA NA Rat Human -DTXSID8042478 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8042478 TK.Half.Life NA 10.2 hours 1compartment NA NA Rat Human -DTXSID8042478 Css NA 1.361 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042478 Css NA 8.35 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042478 Css NA 0.8272 mg/L PBTK NA 50% Rat Human -DTXSID8042478 Css NA 4.874 mg/L PBTK NA 95% Rat Human -DTXSID8042503 Clint NA 5.059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042503 Fup NA 0.2063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042503 Vd NA 1.674 L/kg 1compartment NA NA Human Human +DTXSID8042426 TK.Half.Life NA 1.933 hours 1compartment NA NA Rat Human +DTXSID8042426 Css NA 0.01567 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042426 Css NA 0.1189 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042426 Css NA 0.01234 mg/L PBTK NA 50% Rat Human +DTXSID8042426 Css NA 0.07843 mg/L PBTK NA 95% Rat Human +DTXSID8042478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042478 Fup 0.0366 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042478 Vd NA 2.466 L/kg 1compartment NA NA Human Human +DTXSID8042478 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8042478 TK.Half.Life NA 20.96 hours 1compartment NA NA Human Human +DTXSID8042478 Css NA 1.123 mg/L 3compartmentss NA 50% Human Human +DTXSID8042478 Css NA 8.117 mg/L 3compartmentss NA 95% Human Human +DTXSID8042478 Css NA 0.7478 mg/L PBTK NA 50% Human Human +DTXSID8042478 Css NA 5.151 mg/L PBTK NA 95% Human Human +DTXSID8042478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042478 Fup 0.0366 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042478 Vd NA 1.844 L/kg 1compartment NA NA Rat Human +DTXSID8042478 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8042478 TK.Half.Life NA 5.369 hours 1compartment NA NA Rat Human +DTXSID8042478 Css NA 0.1467 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042478 Css NA 0.8239 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042478 Css NA 0.09605 mg/L PBTK NA 50% Rat Human +DTXSID8042478 Css NA 0.5281 mg/L PBTK NA 95% Rat Human +DTXSID8042503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042503 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042503 Vd NA 2.864 L/kg 1compartment NA NA Human Human DTXSID8042503 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042503 TK.Half.Life NA 8.259 hours 1compartment NA NA Human Human -DTXSID8042503 Css NA 0.5192 mg/L 3compartmentss NA 50% Human Human -DTXSID8042503 Css NA 2.726 mg/L 3compartmentss NA 95% Human Human -DTXSID8042503 Css NA 0.3766 mg/L PBTK NA 50% Human Human -DTXSID8042503 Css NA 1.849 mg/L PBTK NA 95% Human Human -DTXSID8042503 Clint NA 5.059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042503 Fup NA 0.2063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042503 Vd NA 1.31 L/kg 1compartment NA NA Rat Human +DTXSID8042503 TK.Half.Life NA 9.303 hours 1compartment NA NA Human Human +DTXSID8042503 Css NA 0.2876 mg/L 3compartmentss NA 50% Human Human +DTXSID8042503 Css NA 1.76 mg/L 3compartmentss NA 95% Human Human +DTXSID8042503 Css NA 0.21 mg/L PBTK NA 50% Human Human +DTXSID8042503 Css NA 1.237 mg/L PBTK NA 95% Human Human +DTXSID8042503 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042503 Fup 0.284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042503 Vd NA 2.175 L/kg 1compartment NA NA Rat Human DTXSID8042503 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042503 TK.Half.Life NA 3.051 hours 1compartment NA NA Rat Human -DTXSID8042503 Css NA 0.2638 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042503 Css NA 1.027 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042503 Css NA 0.1826 mg/L PBTK NA 50% Rat Human -DTXSID8042503 Css NA 0.6519 mg/L PBTK NA 95% Rat Human -DTXSID8042507 Clint NA 0.4024 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042507 Fup NA 0.6795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042507 Vd NA 1 L/kg 1compartment NA NA Human Human +DTXSID8042503 TK.Half.Life NA 2.054 hours 1compartment NA NA Rat Human +DTXSID8042503 Css NA 0.03657 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042503 Css NA 0.1807 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042503 Css NA 0.02669 mg/L PBTK NA 50% Rat Human +DTXSID8042503 Css NA 0.1268 mg/L PBTK NA 95% Rat Human +DTXSID8042507 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042507 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042507 Vd NA 0.8922 L/kg 1compartment NA NA Human Human DTXSID8042507 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042507 TK.Half.Life NA 5.975 hours 1compartment NA NA Human Human -DTXSID8042507 Css NA 0.6312 mg/L 3compartmentss NA 50% Human Human -DTXSID8042507 Css NA 4.296 mg/L 3compartmentss NA 95% Human Human -DTXSID8042507 Css NA 0.5376 mg/L PBTK NA 50% Human Human -DTXSID8042507 Css NA 2.808 mg/L PBTK NA 95% Human Human -DTXSID8042507 Clint NA 0.4024 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042507 Fup NA 0.6795 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042507 Vd NA 0.9523 L/kg 1compartment NA NA Rat Human +DTXSID8042507 TK.Half.Life NA 0.8253 hours 1compartment NA NA Human Human +DTXSID8042507 Css NA 0.0348 mg/L 3compartmentss NA 50% Human Human +DTXSID8042507 Css NA 0.3959 mg/L 3compartmentss NA 95% Human Human +DTXSID8042507 Css NA 0.02812 mg/L PBTK NA 50% Human Human +DTXSID8042507 Css NA 0.2656 mg/L PBTK NA 95% Human Human +DTXSID8042507 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042507 Fup 0.561 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042507 Vd NA 0.8477 L/kg 1compartment NA NA Rat Human DTXSID8042507 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042507 TK.Half.Life NA 2.362 hours 1compartment NA NA Rat Human -DTXSID8042507 Css NA 0.2078 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042507 Css NA 1.437 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042507 Css NA 0.1731 mg/L PBTK NA 50% Rat Human -DTXSID8042507 Css NA 0.8614 mg/L PBTK NA 95% Rat Human -DTXSID8042509 Clint NA 1.149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042509 Fup NA 0.0744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042509 Vd NA 0.4009 L/kg 1compartment NA NA Human Human -DTXSID8042509 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8042509 TK.Half.Life NA 12.14 hours 1compartment NA NA Human Human -DTXSID8042509 Css NA 4.648 mg/L 3compartmentss NA 50% Human Human -DTXSID8042509 Css NA 24.8 mg/L 3compartmentss NA 95% Human Human -DTXSID8042509 Css NA 3.01 mg/L PBTK NA 50% Human Human -DTXSID8042509 Css NA 14.91 mg/L PBTK NA 95% Human Human -DTXSID8042509 Clint NA 1.149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042509 Fup NA 0.0744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042509 Vd NA 0.3896 L/kg 1compartment NA NA Rat Human +DTXSID8042507 TK.Half.Life NA 0.3905 hours 1compartment NA NA Rat Human +DTXSID8042507 Css NA 0.004249 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042507 Css NA 0.03882 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042507 Css NA 0.003472 mg/L PBTK NA 50% Rat Human +DTXSID8042507 Css NA 0.02639 mg/L PBTK NA 95% Rat Human +DTXSID8042509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042509 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042509 Vd NA 2.236 L/kg 1compartment NA NA Human Human +DTXSID8042509 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8042509 TK.Half.Life NA 7.542 hours 1compartment NA NA Human Human +DTXSID8042509 Css NA 0.3573 mg/L 3compartmentss NA 50% Human Human +DTXSID8042509 Css NA 2.481 mg/L 3compartmentss NA 95% Human Human +DTXSID8042509 Css NA 0.2457 mg/L PBTK NA 50% Human Human +DTXSID8042509 Css NA 1.647 mg/L PBTK NA 95% Human Human +DTXSID8042509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042509 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042509 Vd NA 1.693 L/kg 1compartment NA NA Rat Human DTXSID8042509 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042509 TK.Half.Life NA 6.027 hours 1compartment NA NA Rat Human -DTXSID8042509 Css NA 2.006 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042509 Css NA 8.538 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042509 Css NA 1.213 mg/L PBTK NA 50% Rat Human -DTXSID8042509 Css NA 4.761 mg/L PBTK NA 95% Rat Human -DTXSID8042559 Clint NA 64.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042559 Fup NA 0.1233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042559 Vd NA 1.731 L/kg 1compartment NA NA Human Human +DTXSID8042509 TK.Half.Life NA 2.288 hours 1compartment NA NA Rat Human +DTXSID8042509 Css NA 0.04564 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042509 Css NA 0.2529 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042509 Css NA 0.03107 mg/L PBTK NA 50% Rat Human +DTXSID8042509 Css NA 0.164 mg/L PBTK NA 95% Rat Human +DTXSID8042559 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042559 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042559 Vd NA 1.578 L/kg 1compartment NA NA Human Human DTXSID8042559 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042559 TK.Half.Life NA 2.475 hours 1compartment NA NA Human Human -DTXSID8042559 Css NA 0.09343 mg/L 3compartmentss NA 50% Human Human -DTXSID8042559 Css NA 0.7245 mg/L 3compartmentss NA 95% Human Human -DTXSID8042559 Css NA 0.06321 mg/L PBTK NA 50% Human Human -DTXSID8042559 Css NA 0.462 mg/L PBTK NA 95% Human Human -DTXSID8042559 Clint NA 64.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042559 Fup NA 0.1233 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042559 Vd NA 1.326 L/kg 1compartment NA NA Rat Human +DTXSID8042559 TK.Half.Life NA 10.58 hours 1compartment NA NA Human Human +DTXSID8042559 Css NA 0.8678 mg/L 3compartmentss NA 50% Human Human +DTXSID8042559 Css NA 5.601 mg/L 3compartmentss NA 95% Human Human +DTXSID8042559 Css NA 0.586 mg/L PBTK NA 50% Human Human +DTXSID8042559 Css NA 3.533 mg/L PBTK NA 95% Human Human +DTXSID8042559 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042559 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042559 Vd NA 1.211 L/kg 1compartment NA NA Rat Human DTXSID8042559 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042559 TK.Half.Life NA 0.8804 hours 1compartment NA NA Rat Human -DTXSID8042559 Css NA 0.05272 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042559 Css NA 0.3235 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042559 Css NA 0.03392 mg/L PBTK NA 50% Rat Human -DTXSID8042559 Css NA 0.2013 mg/L PBTK NA 95% Rat Human -DTXSID8042632 Clint NA 10.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042632 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8042632 Vd NA 2.374 L/kg 1compartment NA NA Human Human +DTXSID8042559 TK.Half.Life NA 3.97 hours 1compartment NA NA Rat Human +DTXSID8042559 Css NA 0.1063 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042559 Css NA 0.5058 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042559 Css NA 0.06989 mg/L PBTK NA 50% Rat Human +DTXSID8042559 Css NA 0.3102 mg/L PBTK NA 95% Rat Human +DTXSID8042632 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042632 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8042632 Vd NA 3.357 L/kg 1compartment NA NA Human Human DTXSID8042632 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8042632 TK.Half.Life NA 6.652 hours 1compartment NA NA Human Human -DTXSID8042632 Css NA 0.2668 mg/L 3compartmentss NA 50% Human Human -DTXSID8042632 Css NA 2.397 mg/L 3compartmentss NA 95% Human Human -DTXSID8042632 Css NA 0.2338 mg/L PBTK NA 50% Human Human -DTXSID8042632 Css NA 1.701 mg/L PBTK NA 95% Human Human -DTXSID8042632 Clint NA 10.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042632 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8042632 Vd NA 2.369 L/kg 1compartment NA NA Rat Human +DTXSID8042632 TK.Half.Life NA 8.991 hours 1compartment NA NA Human Human +DTXSID8042632 Css NA 0.173 mg/L 3compartmentss NA 50% Human Human +DTXSID8042632 Css NA 1.297 mg/L 3compartmentss NA 95% Human Human +DTXSID8042632 Css NA 0.1896 mg/L PBTK NA 50% Human Human +DTXSID8042632 Css NA 1.138 mg/L PBTK NA 95% Human Human +DTXSID8042632 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042632 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8042632 Vd NA 3.379 L/kg 1compartment NA NA Rat Human DTXSID8042632 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8042632 TK.Half.Life NA 4.035 hours 1compartment NA NA Rat Human -DTXSID8042632 Css NA 0.1434 mg/L 3compartmentss NA 50% Rat Human -DTXSID8042632 Css NA 1.012 mg/L 3compartmentss NA 95% Rat Human -DTXSID8042632 Css NA 0.1218 mg/L PBTK NA 50% Rat Human -DTXSID8042632 Css NA 0.6778 mg/L PBTK NA 95% Rat Human -DTXSID8043814 Clint NA 1.138 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8043814 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8043814 Vd NA 2.755 L/kg 1compartment NA NA Human Human -DTXSID8043814 Days.Css NA 108 Days PBTK NA NA Human Human -DTXSID8043814 TK.Half.Life NA 463 hours 1compartment NA NA Human Human -DTXSID8043814 Css NA 22.82 mg/L 3compartmentss NA 50% Human Human -DTXSID8043814 Css NA 96.04 mg/L 3compartmentss NA 95% Human Human -DTXSID8043814 Css NA 15.48 mg/L PBTK NA 50% Human Human -DTXSID8043814 Css NA 62.4 mg/L PBTK NA 95% Human Human -DTXSID8043814 Clint NA 1.138 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8043814 Fup NA 0.0344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8043814 Vd NA 2.062 L/kg 1compartment NA NA Rat Human -DTXSID8043814 Days.Css NA 49 Days PBTK NA NA Rat Human -DTXSID8043814 TK.Half.Life NA 78.92 hours 1compartment NA NA Rat Human -DTXSID8043814 Css NA 11 mg/L 3compartmentss NA 50% Rat Human -DTXSID8043814 Css NA 32.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID8043814 Css NA 7.112 mg/L PBTK NA 50% Rat Human -DTXSID8043814 Css NA 19.34 mg/L PBTK NA 95% Rat Human -DTXSID8043941 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8043941 Fup NA 0.9935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8043941 Vd NA 1.66 L/kg 1compartment NA NA Human Human +DTXSID8042632 TK.Half.Life NA 5.361 hours 1compartment NA NA Rat Human +DTXSID8042632 Css NA 0.02015 mg/L 3compartmentss NA 50% Rat Human +DTXSID8042632 Css NA 0.1063 mg/L 3compartmentss NA 95% Rat Human +DTXSID8042632 Css NA 0.02327 mg/L PBTK NA 50% Rat Human +DTXSID8042632 Css NA 0.09328 mg/L PBTK NA 95% Rat Human +DTXSID80436500 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80436500 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80436500 Vd NA 2.332 L/kg 1compartment NA NA Human Human +DTXSID80436500 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID80436500 TK.Half.Life NA 20.75 hours 1compartment NA NA Human Human +DTXSID80436500 Css NA 0.8466 mg/L 3compartmentss NA 50% Human Human +DTXSID80436500 Css NA 5.088 mg/L 3compartmentss NA 95% Human Human +DTXSID80436500 Css NA 0.586 mg/L PBTK NA 50% Human Human +DTXSID80436500 Css NA 3.34 mg/L PBTK NA 95% Human Human +DTXSID80436500 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80436500 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80436500 Vd NA 1.767 L/kg 1compartment NA NA Rat Human +DTXSID80436500 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID80436500 TK.Half.Life NA 5.663 hours 1compartment NA NA Rat Human +DTXSID80436500 Css NA 0.01641 mg/L 3compartmentss NA 50% Rat Human +DTXSID80436500 Css NA 0.1291 mg/L 3compartmentss NA 95% Rat Human +DTXSID80436500 Css NA 0.01089 mg/L PBTK NA 50% Rat Human +DTXSID80436500 Css NA 0.08343 mg/L PBTK NA 95% Rat Human +DTXSID80437072 Clint 1.4 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80437072 Fup 0.0192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80437072 Vd NA 3.063 L/kg 1compartment NA NA Human Human +DTXSID80437072 Days.Css NA 267 Days PBTK NA NA Human Human +DTXSID80437072 TK.Half.Life NA 1055 hours 1compartment NA NA Human Human +DTXSID80437072 Css NA 42.91 mg/L 3compartmentss NA 50% Human Human +DTXSID80437072 Css NA 243.6 mg/L 3compartmentss NA 95% Human Human +DTXSID80437072 Css NA 29.61 mg/L PBTK NA 50% Human Human +DTXSID80437072 Css NA 164.2 mg/L PBTK NA 95% Human Human +DTXSID80437072 Clint 1.4 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80437072 Fup 0.0192 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80437072 Vd NA 2.294 L/kg 1compartment NA NA Rat Human +DTXSID80437072 Days.Css NA 137 Days PBTK NA NA Rat Human +DTXSID80437072 TK.Half.Life NA 142.5 hours 1compartment NA NA Rat Human +DTXSID80437072 Css NA 5.336 mg/L 3compartmentss NA 50% Rat Human +DTXSID80437072 Css NA 23.39 mg/L 3compartmentss NA 95% Rat Human +DTXSID80437072 Css NA 3.656 mg/L PBTK NA 50% Rat Human +DTXSID80437072 Css NA 15.68 mg/L PBTK NA 95% Rat Human +DTXSID8043814 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8043814 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8043814 Vd NA 3.044 L/kg 1compartment NA NA Human Human +DTXSID8043814 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8043814 TK.Half.Life NA 34.2 hours 1compartment NA NA Human Human +DTXSID8043814 Css NA 1.278 mg/L 3compartmentss NA 50% Human Human +DTXSID8043814 Css NA 8.137 mg/L 3compartmentss NA 95% Human Human +DTXSID8043814 Css NA 0.891 mg/L PBTK NA 50% Human Human +DTXSID8043814 Css NA 5.43 mg/L PBTK NA 95% Human Human +DTXSID8043814 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8043814 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8043814 Vd NA 2.286 L/kg 1compartment NA NA Rat Human +DTXSID8043814 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8043814 TK.Half.Life NA 5.415 hours 1compartment NA NA Rat Human +DTXSID8043814 Css NA 0.1645 mg/L 3compartmentss NA 50% Rat Human +DTXSID8043814 Css NA 0.8756 mg/L 3compartmentss NA 95% Rat Human +DTXSID8043814 Css NA 0.1137 mg/L PBTK NA 50% Rat Human +DTXSID8043814 Css NA 0.5885 mg/L PBTK NA 95% Rat Human +DTXSID8043941 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8043941 Fup 0.782 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8043941 Vd NA 1.415 L/kg 1compartment NA NA Human Human DTXSID8043941 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8043941 TK.Half.Life NA 10.83 hours 1compartment NA NA Human Human -DTXSID8043941 Css NA 0.7496 mg/L 3compartmentss NA 50% Human Human -DTXSID8043941 Css NA 5.201 mg/L 3compartmentss NA 95% Human Human -DTXSID8043941 Css NA 0.7188 mg/L PBTK NA 50% Human Human -DTXSID8043941 Css NA 3.536 mg/L PBTK NA 95% Human Human -DTXSID8043941 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8043941 Fup NA 0.9935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8043941 Vd NA 1.688 L/kg 1compartment NA NA Rat Human +DTXSID8043941 TK.Half.Life NA 11.73 hours 1compartment NA NA Human Human +DTXSID8043941 Css NA 0.8743 mg/L 3compartmentss NA 50% Human Human +DTXSID8043941 Css NA 5.939 mg/L 3compartmentss NA 95% Human Human +DTXSID8043941 Css NA 0.7998 mg/L PBTK NA 50% Human Human +DTXSID8043941 Css NA 3.94 mg/L PBTK NA 95% Human Human +DTXSID8043941 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8043941 Fup 0.782 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8043941 Vd NA 1.437 L/kg 1compartment NA NA Rat Human DTXSID8043941 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8043941 TK.Half.Life NA 3.747 hours 1compartment NA NA Rat Human -DTXSID8043941 Css NA 0.1884 mg/L 3compartmentss NA 50% Rat Human -DTXSID8043941 Css NA 1.164 mg/L 3compartmentss NA 95% Rat Human -DTXSID8043941 Css NA 0.1788 mg/L PBTK NA 50% Rat Human -DTXSID8043941 Css NA 0.7432 mg/L PBTK NA 95% Rat Human -DTXSID8044175 Clint NA 6.882 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044175 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044175 Vd NA 1.729 L/kg 1compartment NA NA Human Human -DTXSID8044175 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044175 TK.Half.Life NA 1.596 hours 1compartment NA NA Human Human -DTXSID8044175 Css NA 0.06229 mg/L 3compartmentss NA 50% Human Human -DTXSID8044175 Css NA 0.6221 mg/L 3compartmentss NA 95% Human Human -DTXSID8044175 Css NA 0.0593 mg/L PBTK NA 50% Human Human -DTXSID8044175 Css NA 0.4882 mg/L PBTK NA 95% Human Human -DTXSID8044175 Clint NA 6.882 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044175 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044175 Vd NA 1.764 L/kg 1compartment NA NA Rat Human -DTXSID8044175 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044175 TK.Half.Life NA 0.8556 hours 1compartment NA NA Rat Human -DTXSID8044175 Css NA 0.02883 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044175 Css NA 0.2365 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044175 Css NA 0.02782 mg/L PBTK NA 50% Rat Human -DTXSID8044175 Css NA 0.1651 mg/L PBTK NA 95% Rat Human -DTXSID8044177 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044177 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044177 Vd NA 0.6922 L/kg 1compartment NA NA Human Human -DTXSID8044177 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044177 TK.Half.Life NA 4.481 hours 1compartment NA NA Human Human -DTXSID8044177 Css NA 0.8486 mg/L 3compartmentss NA 50% Human Human -DTXSID8044177 Css NA 5.577 mg/L 3compartmentss NA 95% Human Human -DTXSID8044177 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID8044177 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID8044177 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044177 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044177 Vd NA 0.7437 L/kg 1compartment NA NA Rat Human -DTXSID8044177 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044177 TK.Half.Life NA 1.639 hours 1compartment NA NA Rat Human -DTXSID8044177 Css NA 0.2132 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044177 Css NA 1.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044177 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID8044177 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID8043941 TK.Half.Life NA 4.051 hours 1compartment NA NA Rat Human +DTXSID8043941 Css NA 0.05126 mg/L 3compartmentss NA 50% Rat Human +DTXSID8043941 Css NA 0.3348 mg/L 3compartmentss NA 95% Rat Human +DTXSID8043941 Css NA 0.04769 mg/L PBTK NA 50% Rat Human +DTXSID8043941 Css NA 0.2148 mg/L PBTK NA 95% Rat Human +DTXSID8044123 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID8044123 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8044123 Vd NA 1.08 L/kg 1compartment NA NA Human Human +DTXSID8044123 Days.Css NA 19 Days PBTK NA NA Human Human +DTXSID8044123 TK.Half.Life NA 100.2 hours 1compartment NA NA Human Human +DTXSID8044123 Css NA 15.96 mg/L 3compartmentss NA 50% Human Human +DTXSID8044123 Css NA 121.4 mg/L 3compartmentss NA 95% Human Human +DTXSID8044123 Css NA 9.762 mg/L PBTK NA 50% Human Human +DTXSID8044123 Css NA 70.27 mg/L PBTK NA 95% Human Human +DTXSID8044123 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID8044123 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8044123 Vd NA 0.7964 L/kg 1compartment NA NA Rat Human +DTXSID8044123 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID8044123 TK.Half.Life NA 39.84 hours 1compartment NA NA Rat Human +DTXSID8044123 Css NA 1.92 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044123 Css NA 11.65 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044123 Css NA 1.125 mg/L PBTK NA 50% Rat Human +DTXSID8044123 Css NA 6.6 mg/L PBTK NA 95% Rat Human DTXSID8044200 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8044200 Fup NA 0.5817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044200 Vd NA 0.4908 L/kg 1compartment NA NA Human Human +DTXSID8044200 Vd NA 0.4337 L/kg 1compartment NA NA Human Human DTXSID8044200 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044200 TK.Half.Life NA 5.458 hours 1compartment NA NA Human Human +DTXSID8044200 TK.Half.Life NA 4.824 hours 1compartment NA NA Human Human DTXSID8044200 Css NA 1.354 mg/L 3compartmentss NA 50% Human Human -DTXSID8044200 Css NA 9.288 mg/L 3compartmentss NA 95% Human Human -DTXSID8044200 Css NA 1.011 mg/L PBTK NA 50% Human Human -DTXSID8044200 Css NA 5.749 mg/L PBTK NA 95% Human Human +DTXSID8044200 Css NA 8.605 mg/L 3compartmentss NA 95% Human Human +DTXSID8044200 Css NA 0.9817 mg/L PBTK NA 50% Human Human +DTXSID8044200 Css NA 5.263 mg/L PBTK NA 95% Human Human DTXSID8044200 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8044200 Fup NA 0.5817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044200 Vd NA 0.4977 L/kg 1compartment NA NA Rat Human +DTXSID8044200 Vd NA 0.4455 L/kg 1compartment NA NA Rat Human DTXSID8044200 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044200 TK.Half.Life NA 1.886 hours 1compartment NA NA Rat Human -DTXSID8044200 Css NA 0.3554 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044200 Css NA 2.16 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044200 Css NA 0.2546 mg/L PBTK NA 50% Rat Human -DTXSID8044200 Css NA 1.244 mg/L PBTK NA 95% Rat Human -DTXSID8044204 Clint NA 114.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044204 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044204 Vd NA 3.137 L/kg 1compartment NA NA Human Human -DTXSID8044204 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044204 TK.Half.Life NA 7.058 hours 1compartment NA NA Human Human -DTXSID8044204 Css NA 0.1798 mg/L 3compartmentss NA 50% Human Human -DTXSID8044204 Css NA 1.211 mg/L 3compartmentss NA 95% Human Human -DTXSID8044204 Css NA 0.1258 mg/L PBTK NA 50% Human Human -DTXSID8044204 Css NA 0.8198 mg/L PBTK NA 95% Human Human -DTXSID8044204 Clint NA 114.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044204 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044204 Vd NA 2.365 L/kg 1compartment NA NA Rat Human -DTXSID8044204 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044204 TK.Half.Life NA 1.452 hours 1compartment NA NA Rat Human -DTXSID8044204 Css NA 0.1016 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044204 Css NA 0.5279 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044204 Css NA 0.06798 mg/L PBTK NA 50% Rat Human -DTXSID8044204 Css NA 0.3381 mg/L PBTK NA 95% Rat Human -DTXSID8044206 Clint NA 15.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044206 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044206 Vd NA 0.2134 L/kg 1compartment NA NA Human Human +DTXSID8044200 TK.Half.Life NA 1.689 hours 1compartment NA NA Rat Human +DTXSID8044200 Css NA 0.0832 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044200 Css NA 0.4784 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044200 Css NA 0.05962 mg/L PBTK NA 50% Rat Human +DTXSID8044200 Css NA 0.2834 mg/L PBTK NA 95% Rat Human +DTXSID8044204 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044204 Fup 0.0438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044204 Vd NA 3.156 L/kg 1compartment NA NA Human Human +DTXSID8044204 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8044204 TK.Half.Life NA 25.97 hours 1compartment NA NA Human Human +DTXSID8044204 Css NA 0.8924 mg/L 3compartmentss NA 50% Human Human +DTXSID8044204 Css NA 6.095 mg/L 3compartmentss NA 95% Human Human +DTXSID8044204 Css NA 0.6236 mg/L PBTK NA 50% Human Human +DTXSID8044204 Css NA 4.141 mg/L PBTK NA 95% Human Human +DTXSID8044204 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044204 Fup 0.0438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044204 Vd NA 2.382 L/kg 1compartment NA NA Rat Human +DTXSID8044204 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8044204 TK.Half.Life NA 3.952 hours 1compartment NA NA Rat Human +DTXSID8044204 Css NA 0.1165 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044204 Css NA 0.6934 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044204 Css NA 0.08068 mg/L PBTK NA 50% Rat Human +DTXSID8044204 Css NA 0.467 mg/L PBTK NA 95% Rat Human +DTXSID8044206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044206 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044206 Vd NA 0.2532 L/kg 1compartment NA NA Human Human DTXSID8044206 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044206 TK.Half.Life NA 5.216 hours 1compartment NA NA Human Human -DTXSID8044206 Css NA 4.501 mg/L 3compartmentss NA 50% Human Human -DTXSID8044206 Css NA 43.78 mg/L 3compartmentss NA 95% Human Human -DTXSID8044206 Css NA 2.644 mg/L PBTK NA 50% Human Human -DTXSID8044206 Css NA 25.33 mg/L PBTK NA 95% Human Human -DTXSID8044206 Clint NA 15.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044206 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044206 Vd NA 0.2039 L/kg 1compartment NA NA Rat Human +DTXSID8044206 TK.Half.Life NA 2.303 hours 1compartment NA NA Human Human +DTXSID8044206 Css NA 1.517 mg/L 3compartmentss NA 50% Human Human +DTXSID8044206 Css NA 14.71 mg/L 3compartmentss NA 95% Human Human +DTXSID8044206 Css NA 0.9146 mg/L PBTK NA 50% Human Human +DTXSID8044206 Css NA 8.679 mg/L PBTK NA 95% Human Human +DTXSID8044206 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044206 Fup 0.0211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044206 Vd NA 0.2411 L/kg 1compartment NA NA Rat Human DTXSID8044206 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044206 TK.Half.Life NA 3.313 hours 1compartment NA NA Rat Human -DTXSID8044206 Css NA 2.528 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044206 Css NA 19.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044206 Css NA 1.391 mg/L PBTK NA 50% Rat Human -DTXSID8044206 Css NA 10.64 mg/L PBTK NA 95% Rat Human -DTXSID8044208 Clint NA 6.158 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044208 Fup NA 0.1395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044208 Vd NA 1.626 L/kg 1compartment NA NA Human Human +DTXSID8044206 TK.Half.Life NA 1.438 hours 1compartment NA NA Rat Human +DTXSID8044206 Css NA 0.1986 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044206 Css NA 1.569 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044206 Css NA 0.1149 mg/L PBTK NA 50% Rat Human +DTXSID8044206 Css NA 0.8866 mg/L PBTK NA 95% Rat Human +DTXSID8044208 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044208 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044208 Vd NA 1.197 L/kg 1compartment NA NA Human Human DTXSID8044208 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044208 TK.Half.Life NA 9.544 hours 1compartment NA NA Human Human -DTXSID8044208 Css NA 0.7358 mg/L 3compartmentss NA 50% Human Human -DTXSID8044208 Css NA 4.811 mg/L 3compartmentss NA 95% Human Human -DTXSID8044208 Css NA 0.5039 mg/L PBTK NA 50% Human Human -DTXSID8044208 Css NA 3.037 mg/L PBTK NA 95% Human Human -DTXSID8044208 Clint NA 6.158 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044208 Fup NA 0.1395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044208 Vd NA 1.254 L/kg 1compartment NA NA Rat Human +DTXSID8044208 TK.Half.Life NA 3.49 hours 1compartment NA NA Human Human +DTXSID8044208 Css NA 0.263 mg/L 3compartmentss NA 50% Human Human +DTXSID8044208 Css NA 1.546 mg/L 3compartmentss NA 95% Human Human +DTXSID8044208 Css NA 0.1936 mg/L PBTK NA 50% Human Human +DTXSID8044208 Css NA 1.05 mg/L PBTK NA 95% Human Human +DTXSID8044208 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044208 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044208 Vd NA 0.9905 L/kg 1compartment NA NA Rat Human DTXSID8044208 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044208 TK.Half.Life NA 3.553 hours 1compartment NA NA Rat Human -DTXSID8044208 Css NA 0.3878 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044208 Css NA 1.844 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044208 Css NA 0.2531 mg/L PBTK NA 50% Rat Human -DTXSID8044208 Css NA 1.094 mg/L PBTK NA 95% Rat Human -DTXSID8044252 Clint NA 0.1529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044252 Fup NA 0.2716 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044252 Vd NA 0.4849 L/kg 1compartment NA NA Human Human -DTXSID8044252 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044252 TK.Half.Life NA 9.257 hours 1compartment NA NA Human Human -DTXSID8044252 Css NA 2.142 mg/L 3compartmentss NA 50% Human Human -DTXSID8044252 Css NA 8.502 mg/L 3compartmentss NA 95% Human Human -DTXSID8044252 Css NA 1.531 mg/L PBTK NA 50% Human Human -DTXSID8044252 Css NA 5.422 mg/L PBTK NA 95% Human Human -DTXSID8044252 Clint NA 0.1529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044252 Fup NA 0.2716 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044252 Vd NA 0.4738 L/kg 1compartment NA NA Rat Human +DTXSID8044208 TK.Half.Life NA 1.54 hours 1compartment NA NA Rat Human +DTXSID8044208 Css NA 0.03129 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044208 Css NA 0.1354 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044208 Css NA 0.02299 mg/L PBTK NA 50% Rat Human +DTXSID8044208 Css NA 0.08837 mg/L PBTK NA 95% Rat Human +DTXSID8044252 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044252 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044252 Vd NA 0.5599 L/kg 1compartment NA NA Human Human +DTXSID8044252 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8044252 TK.Half.Life NA 10.25 hours 1compartment NA NA Human Human +DTXSID8044252 Css NA 1.681 mg/L 3compartmentss NA 50% Human Human +DTXSID8044252 Css NA 7.143 mg/L 3compartmentss NA 95% Human Human +DTXSID8044252 Css NA 1.275 mg/L PBTK NA 50% Human Human +DTXSID8044252 Css NA 4.678 mg/L PBTK NA 95% Human Human +DTXSID8044252 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044252 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044252 Vd NA 0.5482 L/kg 1compartment NA NA Rat Human DTXSID8044252 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044252 TK.Half.Life NA 3.428 hours 1compartment NA NA Rat Human -DTXSID8044252 Css NA 0.6673 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044252 Css NA 2.239 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044252 Css NA 0.4557 mg/L PBTK NA 50% Rat Human -DTXSID8044252 Css NA 1.317 mg/L PBTK NA 95% Rat Human -DTXSID8044381 Clint NA 7.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044381 Fup NA 0.0626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044381 Vd NA 2.54 L/kg 1compartment NA NA Human Human -DTXSID8044381 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID8044381 TK.Half.Life NA 41.31 hours 1compartment NA NA Human Human -DTXSID8044381 Css NA 2.205 mg/L 3compartmentss NA 50% Human Human -DTXSID8044381 Css NA 12.54 mg/L 3compartmentss NA 95% Human Human -DTXSID8044381 Css NA 1.504 mg/L PBTK NA 50% Human Human -DTXSID8044381 Css NA 8.274 mg/L PBTK NA 95% Human Human -DTXSID8044381 Clint NA 7.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044381 Fup NA 0.0626 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044381 Vd NA 1.906 L/kg 1compartment NA NA Rat Human -DTXSID8044381 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8044381 TK.Half.Life NA 9.75 hours 1compartment NA NA Rat Human -DTXSID8044381 Css NA 1.188 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044381 Css NA 4.994 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044381 Css NA 0.7672 mg/L PBTK NA 50% Rat Human -DTXSID8044381 Css NA 3.123 mg/L PBTK NA 95% Rat Human -DTXSID8044385 Clint NA 5.202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044385 Fup NA 0.4729 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044385 Vd NA 1.663 L/kg 1compartment NA NA Human Human +DTXSID8044252 TK.Half.Life NA 3.408 hours 1compartment NA NA Rat Human +DTXSID8044252 Css NA 0.03052 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044252 Css NA 0.1873 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044252 Css NA 0.02212 mg/L PBTK NA 50% Rat Human +DTXSID8044252 Css NA 0.1219 mg/L PBTK NA 95% Rat Human +DTXSID8044381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044381 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044381 Vd NA 0.795 L/kg 1compartment NA NA Human Human +DTXSID8044381 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8044381 TK.Half.Life NA 1.767 hours 1compartment NA NA Human Human +DTXSID8044381 Css NA 0.214 mg/L 3compartmentss NA 50% Human Human +DTXSID8044381 Css NA 1.775 mg/L 3compartmentss NA 95% Human Human +DTXSID8044381 Css NA 0.1405 mg/L PBTK NA 50% Human Human +DTXSID8044381 Css NA 1.098 mg/L PBTK NA 95% Human Human +DTXSID8044381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044381 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044381 Vd NA 0.6527 L/kg 1compartment NA NA Rat Human +DTXSID8044381 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8044381 TK.Half.Life NA 0.8169 hours 1compartment NA NA Rat Human +DTXSID8044381 Css NA 0.02809 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044381 Css NA 0.1726 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044381 Css NA 0.01774 mg/L PBTK NA 50% Rat Human +DTXSID8044381 Css NA 0.1027 mg/L PBTK NA 95% Rat Human +DTXSID8044385 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044385 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044385 Vd NA 1.039 L/kg 1compartment NA NA Human Human DTXSID8044385 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044385 TK.Half.Life NA 3.806 hours 1compartment NA NA Human Human -DTXSID8044385 Css NA 0.1908 mg/L 3compartmentss NA 50% Human Human -DTXSID8044385 Css NA 1.24 mg/L 3compartmentss NA 95% Human Human -DTXSID8044385 Css NA 0.1582 mg/L PBTK NA 50% Human Human -DTXSID8044385 Css NA 0.8771 mg/L PBTK NA 95% Human Human -DTXSID8044385 Clint NA 5.202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044385 Fup NA 0.4729 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044385 Vd NA 1.375 L/kg 1compartment NA NA Rat Human +DTXSID8044385 TK.Half.Life NA 1.796 hours 1compartment NA NA Human Human +DTXSID8044385 Css NA 0.1164 mg/L 3compartmentss NA 50% Human Human +DTXSID8044385 Css NA 0.8506 mg/L 3compartmentss NA 95% Human Human +DTXSID8044385 Css NA 0.08106 mg/L PBTK NA 50% Human Human +DTXSID8044385 Css NA 0.5616 mg/L PBTK NA 95% Human Human +DTXSID8044385 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044385 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044385 Vd NA 0.8502 L/kg 1compartment NA NA Rat Human DTXSID8044385 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044385 TK.Half.Life NA 1.517 hours 1compartment NA NA Rat Human -DTXSID8044385 Css NA 0.09466 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044385 Css NA 0.486 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044385 Css NA 0.07569 mg/L PBTK NA 50% Rat Human -DTXSID8044385 Css NA 0.3149 mg/L PBTK NA 95% Rat Human -DTXSID8044389 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044389 Fup NA 0.833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044389 Vd NA 1.082 L/kg 1compartment NA NA Human Human +DTXSID8044385 TK.Half.Life NA 0.7825 hours 1compartment NA NA Rat Human +DTXSID8044385 Css NA 0.0147 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044385 Css NA 0.07866 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044385 Css NA 0.0102 mg/L PBTK NA 50% Rat Human +DTXSID8044385 Css NA 0.05063 mg/L PBTK NA 95% Rat Human +DTXSID8044389 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044389 Fup 0.779 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044389 Vd NA 0.8543 L/kg 1compartment NA NA Human Human DTXSID8044389 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044389 TK.Half.Life NA 8.677 hours 1compartment NA NA Human Human -DTXSID8044389 Css NA 0.9123 mg/L 3compartmentss NA 50% Human Human -DTXSID8044389 Css NA 5.682 mg/L 3compartmentss NA 95% Human Human -DTXSID8044389 Css NA 0.8059 mg/L PBTK NA 50% Human Human -DTXSID8044389 Css NA 3.737 mg/L PBTK NA 95% Human Human -DTXSID8044389 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044389 Fup NA 0.833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044389 Vd NA 1.041 L/kg 1compartment NA NA Rat Human +DTXSID8044389 TK.Half.Life NA 7.158 hours 1compartment NA NA Human Human +DTXSID8044389 Css NA 0.8325 mg/L 3compartmentss NA 50% Human Human +DTXSID8044389 Css NA 5.279 mg/L 3compartmentss NA 95% Human Human +DTXSID8044389 Css NA 0.7027 mg/L PBTK NA 50% Human Human +DTXSID8044389 Css NA 3.417 mg/L PBTK NA 95% Human Human +DTXSID8044389 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044389 Fup 0.779 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044389 Vd NA 0.8561 L/kg 1compartment NA NA Rat Human DTXSID8044389 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044389 TK.Half.Life NA 2.776 hours 1compartment NA NA Rat Human -DTXSID8044389 Css NA 0.2341 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044389 Css NA 1.443 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044389 Css NA 0.2019 mg/L PBTK NA 50% Rat Human -DTXSID8044389 Css NA 0.8853 mg/L PBTK NA 95% Rat Human -DTXSID8044410 Clint NA 4.477 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044410 Fup NA 0.3888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044410 Vd NA 0.3192 L/kg 1compartment NA NA Human Human +DTXSID8044389 TK.Half.Life NA 2.428 hours 1compartment NA NA Rat Human +DTXSID8044389 Css NA 0.0158 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044389 Css NA 0.1225 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044389 Css NA 0.01288 mg/L PBTK NA 50% Rat Human +DTXSID8044389 Css NA 0.08062 mg/L PBTK NA 95% Rat Human +DTXSID8044410 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044410 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044410 Vd NA 0.2969 L/kg 1compartment NA NA Human Human DTXSID8044410 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044410 TK.Half.Life NA 0.8164 hours 1compartment NA NA Human Human -DTXSID8044410 Css NA 0.2509 mg/L 3compartmentss NA 50% Human Human -DTXSID8044410 Css NA 1.504 mg/L 3compartmentss NA 95% Human Human -DTXSID8044410 Css NA 0.167 mg/L PBTK NA 50% Human Human -DTXSID8044410 Css NA 0.9401 mg/L PBTK NA 95% Human Human -DTXSID8044410 Clint NA 4.477 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044410 Fup NA 0.3888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044410 Vd NA 0.331 L/kg 1compartment NA NA Rat Human +DTXSID8044410 TK.Half.Life NA 5.263 hours 1compartment NA NA Human Human +DTXSID8044410 Css NA 1.186 mg/L 3compartmentss NA 50% Human Human +DTXSID8044410 Css NA 5.04 mg/L 3compartmentss NA 95% Human Human +DTXSID8044410 Css NA 0.7834 mg/L PBTK NA 50% Human Human +DTXSID8044410 Css NA 3.087 mg/L PBTK NA 95% Human Human +DTXSID8044410 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044410 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044410 Vd NA 0.3102 L/kg 1compartment NA NA Rat Human DTXSID8044410 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044410 TK.Half.Life NA 0.4706 hours 1compartment NA NA Rat Human -DTXSID8044410 Css NA 0.1257 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044410 Css NA 0.5498 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044410 Css NA 0.07921 mg/L PBTK NA 50% Rat Human -DTXSID8044410 Css NA 0.3179 mg/L PBTK NA 95% Rat Human -DTXSID8044412 Clint NA 0.3287 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044412 Fup NA 0.5612 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044412 Vd NA 0.6775 L/kg 1compartment NA NA Human Human +DTXSID8044410 TK.Half.Life NA 1.874 hours 1compartment NA NA Rat Human +DTXSID8044410 Css NA 0.006355 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044410 Css NA 0.02756 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044410 Css NA 0.003977 mg/L PBTK NA 50% Rat Human +DTXSID8044410 Css NA 0.01601 mg/L PBTK NA 95% Rat Human +DTXSID8044412 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044412 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044412 Vd NA 0.4104 L/kg 1compartment NA NA Human Human DTXSID8044412 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044412 TK.Half.Life NA 5.192 hours 1compartment NA NA Human Human -DTXSID8044412 Css NA 0.8512 mg/L 3compartmentss NA 50% Human Human -DTXSID8044412 Css NA 5.753 mg/L 3compartmentss NA 95% Human Human -DTXSID8044412 Css NA 0.659 mg/L PBTK NA 50% Human Human -DTXSID8044412 Css NA 3.567 mg/L PBTK NA 95% Human Human -DTXSID8044412 Clint NA 0.3287 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044412 Fup NA 0.5612 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044412 Vd NA 0.6432 L/kg 1compartment NA NA Rat Human +DTXSID8044412 TK.Half.Life NA 0.8948 hours 1compartment NA NA Human Human +DTXSID8044412 Css NA 0.189 mg/L 3compartmentss NA 50% Human Human +DTXSID8044412 Css NA 1.158 mg/L 3compartmentss NA 95% Human Human +DTXSID8044412 Css NA 0.1295 mg/L PBTK NA 50% Human Human +DTXSID8044412 Css NA 0.7422 mg/L PBTK NA 95% Human Human +DTXSID8044412 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044412 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044412 Vd NA 0.4105 L/kg 1compartment NA NA Rat Human DTXSID8044412 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044412 TK.Half.Life NA 2.013 hours 1compartment NA NA Rat Human -DTXSID8044412 Css NA 0.2805 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044412 Css NA 1.827 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044412 Css NA 0.2078 mg/L PBTK NA 50% Rat Human -DTXSID8044412 Css NA 1.061 mg/L PBTK NA 95% Rat Human -DTXSID8044414 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044414 Fup NA 0.096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044414 Vd NA 0.2491 L/kg 1compartment NA NA Human Human +DTXSID8044412 TK.Half.Life NA 0.4994 hours 1compartment NA NA Rat Human +DTXSID8044412 Css NA 0.02179 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044412 Css NA 0.105 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044412 Css NA 0.01484 mg/L PBTK NA 50% Rat Human +DTXSID8044412 Css NA 0.0649 mg/L PBTK NA 95% Rat Human +DTXSID8044414 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044414 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044414 Vd NA 0.3077 L/kg 1compartment NA NA Human Human DTXSID8044414 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044414 TK.Half.Life NA 9.035 hours 1compartment NA NA Human Human -DTXSID8044414 Css NA 5.72 mg/L 3compartmentss NA 50% Human Human -DTXSID8044414 Css NA 27.52 mg/L 3compartmentss NA 95% Human Human -DTXSID8044414 Css NA 3.491 mg/L PBTK NA 50% Human Human -DTXSID8044414 Css NA 16.03 mg/L PBTK NA 95% Human Human -DTXSID8044414 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044414 Fup NA 0.096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044414 Vd NA 0.2476 L/kg 1compartment NA NA Rat Human +DTXSID8044414 TK.Half.Life NA 0.5747 hours 1compartment NA NA Human Human +DTXSID8044414 Css NA 0.1336 mg/L 3compartmentss NA 50% Human Human +DTXSID8044414 Css NA 0.9998 mg/L 3compartmentss NA 95% Human Human +DTXSID8044414 Css NA 0.08553 mg/L PBTK NA 50% Human Human +DTXSID8044414 Css NA 0.6193 mg/L PBTK NA 95% Human Human +DTXSID8044414 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044414 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044414 Vd NA 0.3066 L/kg 1compartment NA NA Rat Human DTXSID8044414 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044414 TK.Half.Life NA 4.009 hours 1compartment NA NA Rat Human -DTXSID8044414 Css NA 2.171 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044414 Css NA 8.525 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044414 Css NA 1.239 mg/L PBTK NA 50% Rat Human -DTXSID8044414 Css NA 4.675 mg/L PBTK NA 95% Rat Human -DTXSID8044416 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044416 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044416 Vd NA 0.7789 L/kg 1compartment NA NA Human Human +DTXSID8044414 TK.Half.Life NA 0.3224 hours 1compartment NA NA Rat Human +DTXSID8044414 Css NA 0.01728 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044414 Css NA 0.09046 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044414 Css NA 0.01088 mg/L PBTK NA 50% Rat Human +DTXSID8044414 Css NA 0.055 mg/L PBTK NA 95% Rat Human +DTXSID8044416 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044416 Fup 0.842 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044416 Vd NA 0.6933 L/kg 1compartment NA NA Human Human DTXSID8044416 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044416 TK.Half.Life NA 5.041 hours 1compartment NA NA Human Human -DTXSID8044416 Css NA 0.8268 mg/L 3compartmentss NA 50% Human Human -DTXSID8044416 Css NA 5.561 mg/L 3compartmentss NA 95% Human Human -DTXSID8044416 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID8044416 Css NA 3.572 mg/L PBTK NA 95% Human Human -DTXSID8044416 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044416 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044416 Vd NA 0.8165 L/kg 1compartment NA NA Rat Human +DTXSID8044416 TK.Half.Life NA 5.328 hours 1compartment NA NA Human Human +DTXSID8044416 Css NA 0.8324 mg/L 3compartmentss NA 50% Human Human +DTXSID8044416 Css NA 4.876 mg/L 3compartmentss NA 95% Human Human +DTXSID8044416 Css NA 0.6765 mg/L PBTK NA 50% Human Human +DTXSID8044416 Css NA 3.121 mg/L PBTK NA 95% Human Human +DTXSID8044416 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044416 Fup 0.842 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044416 Vd NA 0.7279 L/kg 1compartment NA NA Rat Human DTXSID8044416 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044416 TK.Half.Life NA 1.801 hours 1compartment NA NA Rat Human -DTXSID8044416 Css NA 0.208 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044416 Css NA 1.329 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044416 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID8044416 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID8044462 Clint NA 38.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044462 Fup NA 0.0214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044462 Vd NA 0.9365 L/kg 1compartment NA NA Human Human -DTXSID8044462 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044462 TK.Half.Life NA 4.868 hours 1compartment NA NA Human Human -DTXSID8044462 Css NA 0.7908 mg/L 3compartmentss NA 50% Human Human -DTXSID8044462 Css NA 7.709 mg/L 3compartmentss NA 95% Human Human -DTXSID8044462 Css NA 0.4784 mg/L PBTK NA 50% Human Human -DTXSID8044462 Css NA 4.546 mg/L PBTK NA 95% Human Human -DTXSID8044462 Clint NA 38.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044462 Fup NA 0.0214 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044462 Vd NA 0.7009 L/kg 1compartment NA NA Rat Human -DTXSID8044462 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044462 TK.Half.Life NA 2.144 hours 1compartment NA NA Rat Human -DTXSID8044462 Css NA 0.4477 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044462 Css NA 3.472 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044462 Css NA 0.255 mg/L PBTK NA 50% Rat Human -DTXSID8044462 Css NA 1.913 mg/L PBTK NA 95% Rat Human -DTXSID8044464 Clint NA 3.336 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044464 Fup NA 0.0363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044464 Vd NA 0.7889 L/kg 1compartment NA NA Human Human -DTXSID8044464 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8044464 TK.Half.Life NA 21.51 hours 1compartment NA NA Human Human -DTXSID8044464 Css NA 4.905 mg/L 3compartmentss NA 50% Human Human -DTXSID8044464 Css NA 30.56 mg/L 3compartmentss NA 95% Human Human -DTXSID8044464 Css NA 2.979 mg/L PBTK NA 50% Human Human -DTXSID8044464 Css NA 17.98 mg/L PBTK NA 95% Human Human -DTXSID8044464 Clint NA 3.336 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044464 Fup NA 0.0363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044464 Vd NA 0.5993 L/kg 1compartment NA NA Rat Human -DTXSID8044464 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8044464 TK.Half.Life NA 9.217 hours 1compartment NA NA Rat Human -DTXSID8044464 Css NA 2.532 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044464 Css NA 11.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044464 Css NA 1.442 mg/L PBTK NA 50% Rat Human -DTXSID8044464 Css NA 6.349 mg/L PBTK NA 95% Rat Human -DTXSID8044466 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044466 Fup NA 0.3383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044466 Vd NA 0.555 L/kg 1compartment NA NA Human Human +DTXSID8044416 TK.Half.Life NA 1.906 hours 1compartment NA NA Rat Human +DTXSID8044416 Css NA 0.01533 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044416 Css NA 0.1139 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044416 Css NA 0.0121 mg/L PBTK NA 50% Rat Human +DTXSID8044416 Css NA 0.07387 mg/L PBTK NA 95% Rat Human +DTXSID8044464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044464 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044464 Vd NA 2.191 L/kg 1compartment NA NA Human Human +DTXSID8044464 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8044464 TK.Half.Life NA 16.98 hours 1compartment NA NA Human Human +DTXSID8044464 Css NA 1.082 mg/L 3compartmentss NA 50% Human Human +DTXSID8044464 Css NA 7.391 mg/L 3compartmentss NA 95% Human Human +DTXSID8044464 Css NA 0.7078 mg/L PBTK NA 50% Human Human +DTXSID8044464 Css NA 4.69 mg/L PBTK NA 95% Human Human +DTXSID8044464 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044464 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044464 Vd NA 1.634 L/kg 1compartment NA NA Rat Human +DTXSID8044464 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8044464 TK.Half.Life NA 5.016 hours 1compartment NA NA Rat Human +DTXSID8044464 Css NA 0.1393 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044464 Css NA 0.7654 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044464 Css NA 0.08913 mg/L PBTK NA 50% Rat Human +DTXSID8044464 Css NA 0.4815 mg/L PBTK NA 95% Rat Human +DTXSID8044466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044466 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044466 Vd NA 0.4118 L/kg 1compartment NA NA Human Human DTXSID8044466 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8044466 TK.Half.Life NA 10.61 hours 1compartment NA NA Human Human -DTXSID8044466 Css NA 2.117 mg/L 3compartmentss NA 50% Human Human -DTXSID8044466 Css NA 8.787 mg/L 3compartmentss NA 95% Human Human -DTXSID8044466 Css NA 1.576 mg/L PBTK NA 50% Human Human -DTXSID8044466 Css NA 5.656 mg/L PBTK NA 95% Human Human -DTXSID8044466 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044466 Fup NA 0.3383 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044466 Vd NA 0.5609 L/kg 1compartment NA NA Rat Human +DTXSID8044466 TK.Half.Life NA 14.88 hours 1compartment NA NA Human Human +DTXSID8044466 Css NA 3.736 mg/L 3compartmentss NA 50% Human Human +DTXSID8044466 Css NA 14.25 mg/L 3compartmentss NA 95% Human Human +DTXSID8044466 Css NA 2.498 mg/L PBTK NA 50% Human Human +DTXSID8044466 Css NA 8.758 mg/L PBTK NA 95% Human Human +DTXSID8044466 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044466 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044466 Vd NA 0.4131 L/kg 1compartment NA NA Rat Human DTXSID8044466 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044466 TK.Half.Life NA 3.654 hours 1compartment NA NA Rat Human -DTXSID8044466 Css NA 0.5873 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044466 Css NA 2.055 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044466 Css NA 0.4143 mg/L PBTK NA 50% Rat Human -DTXSID8044466 Css NA 1.225 mg/L PBTK NA 95% Rat Human -DTXSID8044541 Clint NA 0.1102 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044541 Fup NA 0.4068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044541 Vd NA 2.342 L/kg 1compartment NA NA Human Human -DTXSID8044541 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID8044541 TK.Half.Life NA 66.27 hours 1compartment NA NA Human Human -DTXSID8044541 Css NA 2.887 mg/L 3compartmentss NA 50% Human Human -DTXSID8044541 Css NA 9.781 mg/L 3compartmentss NA 95% Human Human -DTXSID8044541 Css NA 2.304 mg/L PBTK NA 50% Human Human -DTXSID8044541 Css NA 6.702 mg/L PBTK NA 95% Human Human -DTXSID8044541 Clint NA 0.1102 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044541 Fup NA 0.4068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044541 Vd NA 1.833 L/kg 1compartment NA NA Rat Human -DTXSID8044541 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8044541 TK.Half.Life NA 11.5 hours 1compartment NA NA Rat Human -DTXSID8044541 Css NA 0.8732 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044541 Css NA 2.618 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044541 Css NA 0.6697 mg/L PBTK NA 50% Rat Human -DTXSID8044541 Css NA 1.654 mg/L PBTK NA 95% Rat Human -DTXSID8044543 Clint NA 8.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044543 Fup NA 0.1627 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044543 Vd NA 0.3095 L/kg 1compartment NA NA Human Human -DTXSID8044543 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044543 TK.Half.Life NA 1.022 hours 1compartment NA NA Human Human -DTXSID8044543 Css NA 0.373 mg/L 3compartmentss NA 50% Human Human -DTXSID8044543 Css NA 2.421 mg/L 3compartmentss NA 95% Human Human -DTXSID8044543 Css NA 0.237 mg/L PBTK NA 50% Human Human -DTXSID8044543 Css NA 1.489 mg/L PBTK NA 95% Human Human -DTXSID8044543 Clint NA 8.889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044543 Fup NA 0.1627 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044543 Vd NA 0.3065 L/kg 1compartment NA NA Rat Human +DTXSID8044466 TK.Half.Life NA 5.089 hours 1compartment NA NA Rat Human +DTXSID8044466 Css NA 0.06746 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044466 Css NA 0.3975 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044466 Css NA 0.04348 mg/L PBTK NA 50% Rat Human +DTXSID8044466 Css NA 0.2415 mg/L PBTK NA 95% Rat Human +DTXSID8044543 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044543 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044543 Vd NA 0.2153 L/kg 1compartment NA NA Human Human +DTXSID8044543 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8044543 TK.Half.Life NA 10.97 hours 1compartment NA NA Human Human +DTXSID8044543 Css NA 4.239 mg/L 3compartmentss NA 50% Human Human +DTXSID8044543 Css NA 20.04 mg/L 3compartmentss NA 95% Human Human +DTXSID8044543 Css NA 2.57 mg/L PBTK NA 50% Human Human +DTXSID8044543 Css NA 11.67 mg/L PBTK NA 95% Human Human +DTXSID8044543 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044543 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044543 Vd NA 0.22 L/kg 1compartment NA NA Rat Human DTXSID8044543 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044543 TK.Half.Life NA 0.6006 hours 1compartment NA NA Rat Human -DTXSID8044543 Css NA 0.1968 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044543 Css NA 0.9835 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044543 Css NA 0.118 mg/L PBTK NA 50% Rat Human -DTXSID8044543 Css NA 0.5616 mg/L PBTK NA 95% Rat Human -DTXSID8044549 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044549 Fup NA 0.4899 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044549 Vd NA 3.134 L/kg 1compartment NA NA Human Human -DTXSID8044549 Days.Css NA 1085 Days PBTK NA NA Human Human -DTXSID8044549 TK.Half.Life NA 4025 hours 1compartment NA NA Human Human -DTXSID8044549 Css NA 143.7 mg/L 3compartmentss NA 50% Human Human -DTXSID8044549 Css NA 402 mg/L 3compartmentss NA 95% Human Human -DTXSID8044549 Css NA 101.6 mg/L PBTK NA 50% Human Human -DTXSID8044549 Css NA 262.6 mg/L PBTK NA 95% Human Human -DTXSID8044549 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044549 Fup NA 0.4899 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044549 Vd NA 2.354 L/kg 1compartment NA NA Rat Human -DTXSID8044549 Days.Css NA 275 Days PBTK NA NA Rat Human -DTXSID8044549 TK.Half.Life NA 253.7 hours 1compartment NA NA Rat Human -DTXSID8044549 Css NA 38.83 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044549 Css NA 85.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044549 Css NA 26.3 mg/L PBTK NA 50% Rat Human -DTXSID8044549 Css NA 52.04 mg/L PBTK NA 95% Rat Human -DTXSID8044591 Clint NA 18.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044591 Fup NA 0.2363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044591 Vd NA 0.5706 L/kg 1compartment NA NA Human Human +DTXSID8044543 TK.Half.Life NA 3.819 hours 1compartment NA NA Rat Human +DTXSID8044543 Css NA 0.02327 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044543 Css NA 0.1118 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044543 Css NA 0.01319 mg/L PBTK NA 50% Rat Human +DTXSID8044543 Css NA 0.06164 mg/L PBTK NA 95% Rat Human +DTXSID8044591 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044591 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044591 Vd NA 0.7417 L/kg 1compartment NA NA Human Human DTXSID8044591 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044591 TK.Half.Life NA 0.9144 hours 1compartment NA NA Human Human -DTXSID8044591 Css NA 0.1066 mg/L 3compartmentss NA 50% Human Human -DTXSID8044591 Css NA 0.7429 mg/L 3compartmentss NA 95% Human Human -DTXSID8044591 Css NA 0.07378 mg/L PBTK NA 50% Human Human -DTXSID8044591 Css NA 0.4711 mg/L PBTK NA 95% Human Human -DTXSID8044591 Clint NA 18.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044591 Fup NA 0.2363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044591 Vd NA 0.5336 L/kg 1compartment NA NA Rat Human +DTXSID8044591 TK.Half.Life NA 1.502 hours 1compartment NA NA Human Human +DTXSID8044591 Css NA 0.1592 mg/L 3compartmentss NA 50% Human Human +DTXSID8044591 Css NA 1.076 mg/L 3compartmentss NA 95% Human Human +DTXSID8044591 Css NA 0.1212 mg/L PBTK NA 50% Human Human +DTXSID8044591 Css NA 0.7547 mg/L PBTK NA 95% Human Human +DTXSID8044591 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044591 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044591 Vd NA 0.7013 L/kg 1compartment NA NA Rat Human DTXSID8044591 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044591 TK.Half.Life NA 0.469 hours 1compartment NA NA Rat Human -DTXSID8044591 Css NA 0.05898 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044591 Css NA 0.3012 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044591 Css NA 0.0387 mg/L PBTK NA 50% Rat Human -DTXSID8044591 Css NA 0.1858 mg/L PBTK NA 95% Rat Human +DTXSID8044591 TK.Half.Life NA 0.7867 hours 1compartment NA NA Rat Human +DTXSID8044591 Css NA 0.01833 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044591 Css NA 0.09405 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044591 Css NA 0.01382 mg/L PBTK NA 50% Rat Human +DTXSID8044591 Css NA 0.06176 mg/L PBTK NA 95% Rat Human DTXSID8044593 Clint 7.31 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8044593 Fup 0.599 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8044593 Vd NA 2.984 L/kg 1compartment NA NA Human Human -DTXSID8044593 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8044593 TK.Half.Life NA 15.66 hours 1compartment NA NA Human Human -DTXSID8044593 Css NA 0.506 mg/L 3compartmentss NA 50% Human Human -DTXSID8044593 Css NA 2.73 mg/L 3compartmentss NA 95% Human Human -DTXSID8044593 Css NA 0.3896 mg/L PBTK NA 50% Human Human -DTXSID8044593 Css NA 1.978 mg/L PBTK NA 95% Human Human +DTXSID8044593 Vd NA 2.446 L/kg 1compartment NA NA Human Human +DTXSID8044593 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8044593 TK.Half.Life NA 5.328 hours 1compartment NA NA Human Human +DTXSID8044593 Css NA 0.09058 mg/L 3compartmentss NA 50% Human Human +DTXSID8044593 Css NA 0.544 mg/L 3compartmentss NA 95% Human Human +DTXSID8044593 Css NA 0.07746 mg/L PBTK NA 50% Human Human +DTXSID8044593 Css NA 0.4298 mg/L PBTK NA 95% Human Human DTXSID8044593 Clint 7.31 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8044593 Fup 0.599 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8044593 Vd NA 2.284 L/kg 1compartment NA NA Rat Human +DTXSID8044593 Vd NA 1.941 L/kg 1compartment NA NA Rat Human DTXSID8044593 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044593 TK.Half.Life NA 2.943 hours 1compartment NA NA Rat Human -DTXSID8044593 Css NA 0.2616 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044593 Css NA 1.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044593 Css NA 0.1957 mg/L PBTK NA 50% Rat Human -DTXSID8044593 Css NA 0.7057 mg/L PBTK NA 95% Rat Human -DTXSID8044595 Clint NA 62.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044595 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044595 Vd NA 2.713 L/kg 1compartment NA NA Human Human -DTXSID8044595 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044595 TK.Half.Life NA 9.102 hours 1compartment NA NA Human Human -DTXSID8044595 Css NA 0.352 mg/L 3compartmentss NA 50% Human Human -DTXSID8044595 Css NA 2.482 mg/L 3compartmentss NA 95% Human Human -DTXSID8044595 Css NA 0.241 mg/L PBTK NA 50% Human Human -DTXSID8044595 Css NA 1.606 mg/L PBTK NA 95% Human Human -DTXSID8044595 Clint NA 62.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044595 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044595 Vd NA 2.034 L/kg 1compartment NA NA Rat Human -DTXSID8044595 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044595 TK.Half.Life NA 2.164 hours 1compartment NA NA Rat Human -DTXSID8044595 Css NA 0.2002 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044595 Css NA 1.058 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044595 Css NA 0.1292 mg/L PBTK NA 50% Rat Human -DTXSID8044595 Css NA 0.6666 mg/L PBTK NA 95% Rat Human -DTXSID8044597 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044597 Fup NA 0.0113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044597 Vd NA 2.068 L/kg 1compartment NA NA Human Human -DTXSID8044597 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID8044597 TK.Half.Life NA 59.5 hours 1compartment NA NA Human Human -DTXSID8044597 Css NA 4.61 mg/L 3compartmentss NA 50% Human Human -DTXSID8044597 Css NA 34.95 mg/L 3compartmentss NA 95% Human Human -DTXSID8044597 Css NA 2.956 mg/L PBTK NA 50% Human Human -DTXSID8044597 Css NA 21.22 mg/L PBTK NA 95% Human Human -DTXSID8044597 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044597 Fup NA 0.0113 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044597 Vd NA 1.534 L/kg 1compartment NA NA Rat Human -DTXSID8044597 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID8044597 TK.Half.Life NA 18.26 hours 1compartment NA NA Rat Human -DTXSID8044597 Css NA 2.55 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044597 Css NA 15.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044597 Css NA 1.542 mg/L PBTK NA 50% Rat Human -DTXSID8044597 Css NA 8.984 mg/L PBTK NA 95% Rat Human -DTXSID8044620 Clint NA 815.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044620 Fup NA 0.2605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044620 Vd NA 0.9138 L/kg 1compartment NA NA Human Human +DTXSID8044593 TK.Half.Life NA 1.606 hours 1compartment NA NA Rat Human +DTXSID8044593 Css NA 0.0009826 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044593 Css NA 0.006074 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044593 Css NA 0.000824 mg/L PBTK NA 50% Rat Human +DTXSID8044593 Css NA 0.004797 mg/L PBTK NA 95% Rat Human +DTXSID8044595 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044595 Fup 0.0129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044595 Vd NA 2.491 L/kg 1compartment NA NA Human Human +DTXSID8044595 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8044595 TK.Half.Life NA 38.85 hours 1compartment NA NA Human Human +DTXSID8044595 Css NA 2.21 mg/L 3compartmentss NA 50% Human Human +DTXSID8044595 Css NA 16.88 mg/L 3compartmentss NA 95% Human Human +DTXSID8044595 Css NA 1.452 mg/L PBTK NA 50% Human Human +DTXSID8044595 Css NA 10.72 mg/L PBTK NA 95% Human Human +DTXSID8044595 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044595 Fup 0.0129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044595 Vd NA 1.856 L/kg 1compartment NA NA Rat Human +DTXSID8044595 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8044595 TK.Half.Life NA 9.594 hours 1compartment NA NA Rat Human +DTXSID8044595 Css NA 0.286 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044595 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044595 Css NA 0.1851 mg/L PBTK NA 50% Rat Human +DTXSID8044595 Css NA 1.144 mg/L PBTK NA 95% Rat Human +DTXSID8044597 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044597 Fup 0.0156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044597 Vd NA 3.108 L/kg 1compartment NA NA Human Human +DTXSID8044597 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID8044597 TK.Half.Life NA 89.28 hours 1compartment NA NA Human Human +DTXSID8044597 Css NA 3 mg/L 3compartmentss NA 50% Human Human +DTXSID8044597 Css NA 19.18 mg/L 3compartmentss NA 95% Human Human +DTXSID8044597 Css NA 2.08 mg/L PBTK NA 50% Human Human +DTXSID8044597 Css NA 13.08 mg/L PBTK NA 95% Human Human +DTXSID8044597 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044597 Fup 0.0156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044597 Vd NA 2.327 L/kg 1compartment NA NA Rat Human +DTXSID8044597 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID8044597 TK.Half.Life NA 12.2 hours 1compartment NA NA Rat Human +DTXSID8044597 Css NA 0.1542 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044597 Css NA 0.9774 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044597 Css NA 0.1032 mg/L PBTK NA 50% Rat Human +DTXSID8044597 Css NA 0.6309 mg/L PBTK NA 95% Rat Human +DTXSID8044599 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044599 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044599 Vd NA 2.561 L/kg 1compartment NA NA Human Human +DTXSID8044599 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8044599 TK.Half.Life NA 6.273 hours 1compartment NA NA Human Human +DTXSID8044599 Css NA 0.1965 mg/L 3compartmentss NA 50% Human Human +DTXSID8044599 Css NA 1.241 mg/L 3compartmentss NA 95% Human Human +DTXSID8044599 Css NA 0.1447 mg/L PBTK NA 50% Human Human +DTXSID8044599 Css NA 0.8604 mg/L PBTK NA 95% Human Human +DTXSID8044599 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044599 Fup 0.244 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044599 Vd NA 1.956 L/kg 1compartment NA NA Rat Human +DTXSID8044599 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8044599 TK.Half.Life NA 1.71 hours 1compartment NA NA Rat Human +DTXSID8044599 Css NA 0.02511 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044599 Css NA 0.1274 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044599 Css NA 0.01831 mg/L PBTK NA 50% Rat Human +DTXSID8044599 Css NA 0.08932 mg/L PBTK NA 95% Rat Human +DTXSID8044620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044620 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044620 Vd NA 1.222 L/kg 1compartment NA NA Human Human DTXSID8044620 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044620 TK.Half.Life NA 0.7127 hours 1compartment NA NA Human Human -DTXSID8044620 Css NA 0.002324 mg/L 3compartmentss NA 50% Human Human -DTXSID8044620 Css NA 0.01812 mg/L 3compartmentss NA 95% Human Human -DTXSID8044620 Css NA 0.001675 mg/L PBTK NA 50% Human Human -DTXSID8044620 Css NA 0.01224 mg/L PBTK NA 95% Human Human -DTXSID8044620 Clint NA 815.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044620 Fup NA 0.2605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044620 Vd NA 0.7854 L/kg 1compartment NA NA Rat Human +DTXSID8044620 TK.Half.Life NA 1.781 hours 1compartment NA NA Human Human +DTXSID8044620 Css NA 0.08563 mg/L 3compartmentss NA 50% Human Human +DTXSID8044620 Css NA 0.6049 mg/L 3compartmentss NA 95% Human Human +DTXSID8044620 Css NA 0.06266 mg/L PBTK NA 50% Human Human +DTXSID8044620 Css NA 0.4099 mg/L PBTK NA 95% Human Human +DTXSID8044620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044620 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044620 Vd NA 1.003 L/kg 1compartment NA NA Rat Human DTXSID8044620 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044620 TK.Half.Life NA 0.2691 hours 1compartment NA NA Rat Human -DTXSID8044620 Css NA 0.001288 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044620 Css NA 0.008279 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044620 Css NA 0.0008914 mg/L PBTK NA 50% Rat Human -DTXSID8044620 Css NA 0.005346 mg/L PBTK NA 95% Rat Human -DTXSID8044622 Clint NA 591 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044622 Fup NA 0.4639 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044622 Vd NA 9.922 L/kg 1compartment NA NA Human Human -DTXSID8044622 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044622 TK.Half.Life NA 15.26 hours 1compartment NA NA Human Human -DTXSID8044622 Css NA 0.07415 mg/L 3compartmentss NA 50% Human Human -DTXSID8044622 Css NA 0.441 mg/L 3compartmentss NA 95% Human Human -DTXSID8044622 Css NA 0.08846 mg/L PBTK NA 50% Human Human -DTXSID8044622 Css NA 0.497 mg/L PBTK NA 95% Human Human -DTXSID8044622 Clint NA 591 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044622 Fup NA 0.4639 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044622 Vd NA 7.807 L/kg 1compartment NA NA Rat Human -DTXSID8044622 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044622 TK.Half.Life NA 2.999 hours 1compartment NA NA Rat Human -DTXSID8044622 Css NA 0.04027 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044622 Css NA 0.1778 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044622 Css NA 0.04782 mg/L PBTK NA 50% Rat Human -DTXSID8044622 Css NA 0.2091 mg/L PBTK NA 95% Rat Human -DTXSID8044626 Clint NA 15.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044626 Fup NA 0.0281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044626 Vd NA 0.6005 L/kg 1compartment NA NA Human Human +DTXSID8044620 TK.Half.Life NA 0.7481 hours 1compartment NA NA Rat Human +DTXSID8044620 Css NA 0.01082 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044620 Css NA 0.05856 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044620 Css NA 0.007868 mg/L PBTK NA 50% Rat Human +DTXSID8044620 Css NA 0.03933 mg/L PBTK NA 95% Rat Human +DTXSID8044626 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044626 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044626 Vd NA 0.9664 L/kg 1compartment NA NA Human Human DTXSID8044626 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044626 TK.Half.Life NA 5.373 hours 1compartment NA NA Human Human -DTXSID8044626 Css NA 1.541 mg/L 3compartmentss NA 50% Human Human -DTXSID8044626 Css NA 13.86 mg/L 3compartmentss NA 95% Human Human -DTXSID8044626 Css NA 0.933 mg/L PBTK NA 50% Human Human -DTXSID8044626 Css NA 8.123 mg/L PBTK NA 95% Human Human -DTXSID8044626 Clint NA 15.58 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044626 Fup NA 0.0281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044626 Vd NA 0.4731 L/kg 1compartment NA NA Rat Human +DTXSID8044626 TK.Half.Life NA 4.245 hours 1compartment NA NA Human Human +DTXSID8044626 Css NA 0.501 mg/L 3compartmentss NA 50% Human Human +DTXSID8044626 Css NA 3.196 mg/L 3compartmentss NA 95% Human Human +DTXSID8044626 Css NA 0.3412 mg/L PBTK NA 50% Human Human +DTXSID8044626 Css NA 2.053 mg/L PBTK NA 95% Human Human +DTXSID8044626 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044626 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044626 Vd NA 0.8058 L/kg 1compartment NA NA Rat Human DTXSID8044626 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044626 TK.Half.Life NA 2.662 hours 1compartment NA NA Rat Human -DTXSID8044626 Css NA 0.8408 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044626 Css NA 5.965 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044626 Css NA 0.4747 mg/L PBTK NA 50% Rat Human -DTXSID8044626 Css NA 3.266 mg/L PBTK NA 95% Rat Human -DTXSID8044670 Clint NA 17.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044670 Fup NA 0.3629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044670 Vd NA 2.106 L/kg 1compartment NA NA Human Human -DTXSID8044670 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044670 TK.Half.Life NA 2.35 hours 1compartment NA NA Human Human -DTXSID8044670 Css NA 0.05443 mg/L 3compartmentss NA 50% Human Human -DTXSID8044670 Css NA 0.4365 mg/L 3compartmentss NA 95% Human Human -DTXSID8044670 Css NA 0.05148 mg/L PBTK NA 50% Human Human -DTXSID8044670 Css NA 0.3331 mg/L PBTK NA 95% Human Human -DTXSID8044670 Clint NA 17.92 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044670 Fup NA 0.3629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044670 Vd NA 2.093 L/kg 1compartment NA NA Rat Human +DTXSID8044626 TK.Half.Life NA 2.001 hours 1compartment NA NA Rat Human +DTXSID8044626 Css NA 0.0608 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044626 Css NA 0.2904 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044626 Css NA 0.04064 mg/L PBTK NA 50% Rat Human +DTXSID8044626 Css NA 0.1765 mg/L PBTK NA 95% Rat Human +DTXSID8044670 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044670 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044670 Vd NA 1.468 L/kg 1compartment NA NA Human Human +DTXSID8044670 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8044670 TK.Half.Life NA 26.95 hours 1compartment NA NA Human Human +DTXSID8044670 Css NA 1.838 mg/L 3compartmentss NA 50% Human Human +DTXSID8044670 Css NA 7.848 mg/L 3compartmentss NA 95% Human Human +DTXSID8044670 Css NA 1.49 mg/L PBTK NA 50% Human Human +DTXSID8044670 Css NA 5.243 mg/L PBTK NA 95% Human Human +DTXSID8044670 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044670 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044670 Vd NA 1.226 L/kg 1compartment NA NA Rat Human DTXSID8044670 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044670 TK.Half.Life NA 1.259 hours 1compartment NA NA Rat Human -DTXSID8044670 Css NA 0.0286 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044670 Css NA 0.1857 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044670 Css NA 0.02624 mg/L PBTK NA 50% Rat Human -DTXSID8044670 Css NA 0.1388 mg/L PBTK NA 95% Rat Human -DTXSID8044676 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044676 Fup NA 0.0542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044676 Vd NA 3.13 L/kg 1compartment NA NA Human Human -DTXSID8044676 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID8044676 TK.Half.Life NA 23560 hours 1compartment NA NA Human Human -DTXSID8044676 Css NA 852.1 mg/L 3compartmentss NA 50% Human Human -DTXSID8044676 Css NA 2360 mg/L 3compartmentss NA 95% Human Human -DTXSID8044676 Css NA 597.7 mg/L PBTK NA 50% Human Human -DTXSID8044676 Css NA 1542 mg/L PBTK NA 95% Human Human -DTXSID8044676 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044676 Fup NA 0.0542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044676 Vd NA 2.354 L/kg 1compartment NA NA Rat Human -DTXSID8044676 Days.Css NA 1667 Days PBTK NA NA Rat Human -DTXSID8044676 TK.Half.Life NA 1512 hours 1compartment NA NA Rat Human -DTXSID8044676 Css NA 232.2 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044676 Css NA 515.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044676 Css NA 155.4 mg/L PBTK NA 50% Rat Human -DTXSID8044676 Css NA 311.7 mg/L PBTK NA 95% Rat Human -DTXSID8044678 Clint NA 11.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044678 Fup NA 0.1075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044678 Vd NA 3.025 L/kg 1compartment NA NA Human Human +DTXSID8044670 TK.Half.Life NA 6.595 hours 1compartment NA NA Rat Human +DTXSID8044670 Css NA 0.1152 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044670 Css NA 0.4305 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044670 Css NA 0.09347 mg/L PBTK NA 50% Rat Human +DTXSID8044670 Css NA 0.2773 mg/L PBTK NA 95% Rat Human +DTXSID8044678 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044678 Fup 0.226 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044678 Vd NA 0.9623 L/kg 1compartment NA NA Human Human DTXSID8044678 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044678 TK.Half.Life NA 9.483 hours 1compartment NA NA Human Human -DTXSID8044678 Css NA 0.3066 mg/L 3compartmentss NA 50% Human Human -DTXSID8044678 Css NA 2.398 mg/L 3compartmentss NA 95% Human Human -DTXSID8044678 Css NA 0.2601 mg/L PBTK NA 50% Human Human -DTXSID8044678 Css NA 1.809 mg/L PBTK NA 95% Human Human -DTXSID8044678 Clint NA 11.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044678 Fup NA 0.1075 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044678 Vd NA 2.76 L/kg 1compartment NA NA Rat Human +DTXSID8044678 TK.Half.Life NA 1.429 hours 1compartment NA NA Human Human +DTXSID8044678 Css NA 0.08792 mg/L 3compartmentss NA 50% Human Human +DTXSID8044678 Css NA 0.6819 mg/L 3compartmentss NA 95% Human Human +DTXSID8044678 Css NA 0.06412 mg/L PBTK NA 50% Human Human +DTXSID8044678 Css NA 0.4593 mg/L PBTK NA 95% Human Human +DTXSID8044678 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044678 Fup 0.226 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044678 Vd NA 0.9631 L/kg 1compartment NA NA Rat Human DTXSID8044678 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044678 TK.Half.Life NA 4.276 hours 1compartment NA NA Rat Human -DTXSID8044678 Css NA 0.1656 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044678 Css NA 0.9888 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044678 Css NA 0.137 mg/L PBTK NA 50% Rat Human -DTXSID8044678 Css NA 0.6895 mg/L PBTK NA 95% Rat Human -DTXSID8044701 Clint NA 107.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044701 Fup NA 0.2019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044701 Vd NA 1.542 L/kg 1compartment NA NA Human Human +DTXSID8044678 TK.Half.Life NA 0.7912 hours 1compartment NA NA Rat Human +DTXSID8044678 Css NA 0.01115 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044678 Css NA 0.06038 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044678 Css NA 0.008118 mg/L PBTK NA 50% Rat Human +DTXSID8044678 Css NA 0.04024 mg/L PBTK NA 95% Rat Human +DTXSID8044701 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044701 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044701 Vd NA 1.27 L/kg 1compartment NA NA Human Human DTXSID8044701 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044701 TK.Half.Life NA 1.513 hours 1compartment NA NA Human Human -DTXSID8044701 Css NA 0.02674 mg/L 3compartmentss NA 50% Human Human -DTXSID8044701 Css NA 0.1939 mg/L 3compartmentss NA 95% Human Human -DTXSID8044701 Css NA 0.01922 mg/L PBTK NA 50% Human Human -DTXSID8044701 Css NA 0.1296 mg/L PBTK NA 95% Human Human -DTXSID8044701 Clint NA 107.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044701 Fup NA 0.2019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044701 Vd NA 1.214 L/kg 1compartment NA NA Rat Human +DTXSID8044701 TK.Half.Life NA 2.817 hours 1compartment NA NA Human Human +DTXSID8044701 Css NA 0.2082 mg/L 3compartmentss NA 50% Human Human +DTXSID8044701 Css NA 1.599 mg/L 3compartmentss NA 95% Human Human +DTXSID8044701 Css NA 0.1401 mg/L PBTK NA 50% Human Human +DTXSID8044701 Css NA 1.027 mg/L PBTK NA 95% Human Human +DTXSID8044701 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044701 Fup 0.135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044701 Vd NA 0.9958 L/kg 1compartment NA NA Rat Human DTXSID8044701 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044701 TK.Half.Life NA 0.5458 hours 1compartment NA NA Rat Human -DTXSID8044701 Css NA 0.01488 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044701 Css NA 0.0809 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044701 Css NA 0.01024 mg/L PBTK NA 50% Rat Human -DTXSID8044701 Css NA 0.0528 mg/L PBTK NA 95% Rat Human +DTXSID8044701 TK.Half.Life NA 1.159 hours 1compartment NA NA Rat Human +DTXSID8044701 Css NA 0.02674 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044701 Css NA 0.1627 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044701 Css NA 0.01759 mg/L PBTK NA 50% Rat Human +DTXSID8044701 Css NA 0.1003 mg/L PBTK NA 95% Rat Human DTXSID8044703 Clint NA 3.103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8044703 Fup NA 0.3571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8044703 Vd NA 2.092 L/kg 1compartment NA NA Human Human DTXSID8044703 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8044703 TK.Half.Life NA 10.89 hours 1compartment NA NA Human Human -DTXSID8044703 Css NA 0.5253 mg/L 3compartmentss NA 50% Human Human -DTXSID8044703 Css NA 2.598 mg/L 3compartmentss NA 95% Human Human -DTXSID8044703 Css NA 0.4112 mg/L PBTK NA 50% Human Human -DTXSID8044703 Css NA 1.82 mg/L PBTK NA 95% Human Human +DTXSID8044703 Css NA 0.508 mg/L 3compartmentss NA 50% Human Human +DTXSID8044703 Css NA 2.522 mg/L 3compartmentss NA 95% Human Human +DTXSID8044703 Css NA 0.3978 mg/L PBTK NA 50% Human Human +DTXSID8044703 Css NA 1.813 mg/L PBTK NA 95% Human Human DTXSID8044703 Clint NA 3.103 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8044703 Fup NA 0.3571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8044703 Vd NA 1.648 L/kg 1compartment NA NA Rat Human DTXSID8044703 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8044703 TK.Half.Life NA 3.415 hours 1compartment NA NA Rat Human -DTXSID8044703 Css NA 0.2508 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044703 Css NA 0.9124 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044703 Css NA 0.1889 mg/L PBTK NA 50% Rat Human -DTXSID8044703 Css NA 0.5933 mg/L PBTK NA 95% Rat Human -DTXSID8044709 Clint NA 8.698 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044709 Fup NA 0.5079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044709 Vd NA 1.492 L/kg 1compartment NA NA Human Human +DTXSID8044703 Css NA 0.05592 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044703 Css NA 0.2015 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044703 Css NA 0.04382 mg/L PBTK NA 50% Rat Human +DTXSID8044703 Css NA 0.1373 mg/L PBTK NA 95% Rat Human +DTXSID8044709 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044709 Fup 0.354 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044709 Vd NA 0.9669 L/kg 1compartment NA NA Human Human DTXSID8044709 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044709 TK.Half.Life NA 2.261 hours 1compartment NA NA Human Human -DTXSID8044709 Css NA 0.103 mg/L 3compartmentss NA 50% Human Human -DTXSID8044709 Css NA 0.7824 mg/L 3compartmentss NA 95% Human Human -DTXSID8044709 Css NA 0.08611 mg/L PBTK NA 50% Human Human -DTXSID8044709 Css NA 0.5449 mg/L PBTK NA 95% Human Human -DTXSID8044709 Clint NA 8.698 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044709 Fup NA 0.5079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044709 Vd NA 1.264 L/kg 1compartment NA NA Rat Human +DTXSID8044709 TK.Half.Life NA 2.193 hours 1compartment NA NA Human Human +DTXSID8044709 Css NA 0.1843 mg/L 3compartmentss NA 50% Human Human +DTXSID8044709 Css NA 1.239 mg/L 3compartmentss NA 95% Human Human +DTXSID8044709 Css NA 0.1393 mg/L PBTK NA 50% Human Human +DTXSID8044709 Css NA 0.8401 mg/L PBTK NA 95% Human Human +DTXSID8044709 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044709 Fup 0.354 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044709 Vd NA 0.8512 L/kg 1compartment NA NA Rat Human DTXSID8044709 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044709 TK.Half.Life NA 0.9586 hours 1compartment NA NA Rat Human -DTXSID8044709 Css NA 0.05342 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044709 Css NA 0.3177 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044709 Css NA 0.04316 mg/L PBTK NA 50% Rat Human -DTXSID8044709 Css NA 0.2079 mg/L PBTK NA 95% Rat Human +DTXSID8044709 TK.Half.Life NA 1.056 hours 1compartment NA NA Rat Human +DTXSID8044709 Css NA 0.0217 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044709 Css NA 0.1038 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044709 Css NA 0.01645 mg/L PBTK NA 50% Rat Human +DTXSID8044709 Css NA 0.0675 mg/L PBTK NA 95% Rat Human DTXSID8044751 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8044751 Fup NA 0.4895 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044751 Vd NA 0.4257 L/kg 1compartment NA NA Human Human +DTXSID8044751 Vd NA 0.4153 L/kg 1compartment NA NA Human Human DTXSID8044751 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044751 TK.Half.Life NA 5.626 hours 1compartment NA NA Human Human -DTXSID8044751 Css NA 1.562 mg/L 3compartmentss NA 50% Human Human -DTXSID8044751 Css NA 7.445 mg/L 3compartmentss NA 95% Human Human -DTXSID8044751 Css NA 1.132 mg/L PBTK NA 50% Human Human -DTXSID8044751 Css NA 4.617 mg/L PBTK NA 95% Human Human +DTXSID8044751 TK.Half.Life NA 5.488 hours 1compartment NA NA Human Human +DTXSID8044751 Css NA 0.8273 mg/L 3compartmentss NA 50% Human Human +DTXSID8044751 Css NA 4.436 mg/L 3compartmentss NA 95% Human Human +DTXSID8044751 Css NA 0.5982 mg/L PBTK NA 50% Human Human +DTXSID8044751 Css NA 2.75 mg/L PBTK NA 95% Human Human DTXSID8044751 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8044751 Fup NA 0.4895 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044751 Vd NA 0.443 L/kg 1compartment NA NA Rat Human +DTXSID8044751 Vd NA 0.4341 L/kg 1compartment NA NA Rat Human DTXSID8044751 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044751 TK.Half.Life NA 1.995 hours 1compartment NA NA Rat Human -DTXSID8044751 Css NA 0.4211 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044751 Css NA 1.813 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044751 Css NA 0.2901 mg/L PBTK NA 50% Rat Human -DTXSID8044751 Css NA 1.054 mg/L PBTK NA 95% Rat Human -DTXSID8044830 Clint NA 3.297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044830 Fup NA 0.4151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044830 Vd NA 1.355 L/kg 1compartment NA NA Human Human +DTXSID8044751 TK.Half.Life NA 1.955 hours 1compartment NA NA Rat Human +DTXSID8044751 Css NA 0.004532 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044751 Css NA 0.02389 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044751 Css NA 0.003122 mg/L PBTK NA 50% Rat Human +DTXSID8044751 Css NA 0.01407 mg/L PBTK NA 95% Rat Human +DTXSID8044830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044830 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044830 Vd NA 0.7646 L/kg 1compartment NA NA Human Human DTXSID8044830 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044830 TK.Half.Life NA 4.455 hours 1compartment NA NA Human Human -DTXSID8044830 Css NA 0.3121 mg/L 3compartmentss NA 50% Human Human -DTXSID8044830 Css NA 1.76 mg/L 3compartmentss NA 95% Human Human -DTXSID8044830 Css NA 0.2434 mg/L PBTK NA 50% Human Human -DTXSID8044830 Css NA 1.207 mg/L PBTK NA 95% Human Human -DTXSID8044830 Clint NA 3.297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044830 Fup NA 0.4151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044830 Vd NA 1.115 L/kg 1compartment NA NA Rat Human +DTXSID8044830 TK.Half.Life NA 0.9659 hours 1compartment NA NA Human Human +DTXSID8044830 Css NA 0.06276 mg/L 3compartmentss NA 50% Human Human +DTXSID8044830 Css NA 0.4715 mg/L 3compartmentss NA 95% Human Human +DTXSID8044830 Css NA 0.045 mg/L PBTK NA 50% Human Human +DTXSID8044830 Css NA 0.311 mg/L PBTK NA 95% Human Human +DTXSID8044830 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044830 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044830 Vd NA 0.6748 L/kg 1compartment NA NA Rat Human DTXSID8044830 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044830 TK.Half.Life NA 1.816 hours 1compartment NA NA Rat Human -DTXSID8044830 Css NA 0.1488 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044830 Css NA 0.646 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044830 Css NA 0.1123 mg/L PBTK NA 50% Rat Human -DTXSID8044830 Css NA 0.4094 mg/L PBTK NA 95% Rat Human +DTXSID8044830 TK.Half.Life NA 0.4426 hours 1compartment NA NA Rat Human +DTXSID8044830 Css NA 0.007905 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044830 Css NA 0.0476 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044830 Css NA 0.005657 mg/L PBTK NA 50% Rat Human +DTXSID8044830 Css NA 0.03104 mg/L PBTK NA 95% Rat Human DTXSID8044834 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8044834 Fup NA 0.9254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044834 Vd NA 0.5608 L/kg 1compartment NA NA Human Human +DTXSID8044834 Vd NA 0.5242 L/kg 1compartment NA NA Human Human DTXSID8044834 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044834 TK.Half.Life NA 3.921 hours 1compartment NA NA Human Human -DTXSID8044834 Css NA 0.9266 mg/L 3compartmentss NA 50% Human Human -DTXSID8044834 Css NA 3.326 mg/L 3compartmentss NA 95% Human Human -DTXSID8044834 Css NA 0.7271 mg/L PBTK NA 50% Human Human -DTXSID8044834 Css NA 2.231 mg/L PBTK NA 95% Human Human +DTXSID8044834 TK.Half.Life NA 3.666 hours 1compartment NA NA Human Human +DTXSID8044834 Css NA 0.8093 mg/L 3compartmentss NA 50% Human Human +DTXSID8044834 Css NA 2.92 mg/L 3compartmentss NA 95% Human Human +DTXSID8044834 Css NA 0.6223 mg/L PBTK NA 50% Human Human +DTXSID8044834 Css NA 1.959 mg/L PBTK NA 95% Human Human DTXSID8044834 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8044834 Fup NA 0.9254 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044834 Vd NA 0.5831 L/kg 1compartment NA NA Rat Human +DTXSID8044834 Vd NA 0.5508 L/kg 1compartment NA NA Rat Human DTXSID8044834 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044834 TK.Half.Life NA 1.389 hours 1compartment NA NA Rat Human -DTXSID8044834 Css NA 0.2418 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044834 Css NA 0.8027 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044834 Css NA 0.1831 mg/L PBTK NA 50% Rat Human -DTXSID8044834 Css NA 0.4977 mg/L PBTK NA 95% Rat Human +DTXSID8044834 TK.Half.Life NA 1.313 hours 1compartment NA NA Rat Human +DTXSID8044834 Css NA 0.01458 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044834 Css NA 0.07776 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044834 Css NA 0.01074 mg/L PBTK NA 50% Rat Human +DTXSID8044834 Css NA 0.05232 mg/L PBTK NA 95% Rat Human DTXSID8044836 Clint 21.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8044836 Fup 0.0196 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8044836 Vd NA 0.6103 L/kg 1compartment NA NA Human Human +DTXSID8044836 Vd NA 0.8029 L/kg 1compartment NA NA Human Human DTXSID8044836 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044836 TK.Half.Life NA 5.668 hours 1compartment NA NA Human Human -DTXSID8044836 Css NA 1.13 mg/L 3compartmentss NA 50% Human Human -DTXSID8044836 Css NA 9.376 mg/L 3compartmentss NA 95% Human Human -DTXSID8044836 Css NA 0.6828 mg/L PBTK NA 50% Human Human -DTXSID8044836 Css NA 5.499 mg/L PBTK NA 95% Human Human +DTXSID8044836 TK.Half.Life NA 7.392 hours 1compartment NA NA Human Human +DTXSID8044836 Css NA 1.072 mg/L 3compartmentss NA 50% Human Human +DTXSID8044836 Css NA 9.179 mg/L 3compartmentss NA 95% Human Human +DTXSID8044836 Css NA 0.6571 mg/L PBTK NA 50% Human Human +DTXSID8044836 Css NA 5.432 mg/L PBTK NA 95% Human Human DTXSID8044836 Clint 21.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8044836 Fup 0.0196 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8044836 Vd NA 0.4666 L/kg 1compartment NA NA Rat Human +DTXSID8044836 Vd NA 0.6026 L/kg 1compartment NA NA Rat Human DTXSID8044836 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044836 TK.Half.Life NA 2.736 hours 1compartment NA NA Rat Human -DTXSID8044836 Css NA 0.6426 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044836 Css NA 4.002 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044836 Css NA 0.3638 mg/L PBTK NA 50% Rat Human -DTXSID8044836 Css NA 2.228 mg/L PBTK NA 95% Rat Human -DTXSID8044880 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044880 Fup NA 0.6615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044880 Vd NA 1.052 L/kg 1compartment NA NA Human Human -DTXSID8044880 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8044880 TK.Half.Life NA 10.36 hours 1compartment NA NA Human Human -DTXSID8044880 Css NA 1.09 mg/L 3compartmentss NA 50% Human Human -DTXSID8044880 Css NA 7.052 mg/L 3compartmentss NA 95% Human Human -DTXSID8044880 Css NA 0.9228 mg/L PBTK NA 50% Human Human -DTXSID8044880 Css NA 4.593 mg/L PBTK NA 95% Human Human -DTXSID8044880 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044880 Fup NA 0.6615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044880 Vd NA 1.055 L/kg 1compartment NA NA Rat Human +DTXSID8044836 TK.Half.Life NA 3.399 hours 1compartment NA NA Rat Human +DTXSID8044836 Css NA 0.1457 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044836 Css NA 0.9207 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044836 Css NA 0.08641 mg/L PBTK NA 50% Rat Human +DTXSID8044836 Css NA 0.5345 mg/L PBTK NA 95% Rat Human +DTXSID8044880 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044880 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044880 Vd NA 0.85 L/kg 1compartment NA NA Human Human +DTXSID8044880 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8044880 TK.Half.Life NA 8.469 hours 1compartment NA NA Human Human +DTXSID8044880 Css NA 1.091 mg/L 3compartmentss NA 50% Human Human +DTXSID8044880 Css NA 7.331 mg/L 3compartmentss NA 95% Human Human +DTXSID8044880 Css NA 0.8964 mg/L PBTK NA 50% Human Human +DTXSID8044880 Css NA 4.696 mg/L PBTK NA 95% Human Human +DTXSID8044880 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044880 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044880 Vd NA 0.8679 L/kg 1compartment NA NA Rat Human DTXSID8044880 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044880 TK.Half.Life NA 3.522 hours 1compartment NA NA Rat Human -DTXSID8044880 Css NA 0.2815 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044880 Css NA 1.836 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044880 Css NA 0.2326 mg/L PBTK NA 50% Rat Human -DTXSID8044880 Css NA 1.103 mg/L PBTK NA 95% Rat Human -DTXSID8044882 Clint NA 1.813 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044882 Fup NA 0.3813 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044882 Vd NA 0.9881 L/kg 1compartment NA NA Human Human +DTXSID8044880 TK.Half.Life NA 2.945 hours 1compartment NA NA Rat Human +DTXSID8044880 Css NA 0.06606 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044880 Css NA 0.4098 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044880 Css NA 0.05417 mg/L PBTK NA 50% Rat Human +DTXSID8044880 Css NA 0.2523 mg/L PBTK NA 95% Rat Human +DTXSID8044882 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044882 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044882 Vd NA 1.601 L/kg 1compartment NA NA Human Human DTXSID8044882 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044882 TK.Half.Life NA 4.774 hours 1compartment NA NA Human Human -DTXSID8044882 Css NA 0.4897 mg/L 3compartmentss NA 50% Human Human -DTXSID8044882 Css NA 2.573 mg/L 3compartmentss NA 95% Human Human -DTXSID8044882 Css NA 0.3758 mg/L PBTK NA 50% Human Human -DTXSID8044882 Css NA 1.714 mg/L PBTK NA 95% Human Human -DTXSID8044882 Clint NA 1.813 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044882 Fup NA 0.3813 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044882 Vd NA 0.8739 L/kg 1compartment NA NA Rat Human +DTXSID8044882 TK.Half.Life NA 1.688 hours 1compartment NA NA Human Human +DTXSID8044882 Css NA 0.04488 mg/L 3compartmentss NA 50% Human Human +DTXSID8044882 Css NA 0.3725 mg/L 3compartmentss NA 95% Human Human +DTXSID8044882 Css NA 0.03703 mg/L PBTK NA 50% Human Human +DTXSID8044882 Css NA 0.2677 mg/L PBTK NA 95% Human Human +DTXSID8044882 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044882 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044882 Vd NA 1.333 L/kg 1compartment NA NA Rat Human DTXSID8044882 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044882 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human -DTXSID8044882 Css NA 0.2148 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044882 Css NA 0.8795 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044882 Css NA 0.1601 mg/L PBTK NA 50% Rat Human -DTXSID8044882 Css NA 0.5411 mg/L PBTK NA 95% Rat Human -DTXSID8044884 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044884 Fup NA 0.692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044884 Vd NA 1.497 L/kg 1compartment NA NA Human Human -DTXSID8044884 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8044884 TK.Half.Life NA 16.34 hours 1compartment NA NA Human Human -DTXSID8044884 Css NA 1.093 mg/L 3compartmentss NA 50% Human Human -DTXSID8044884 Css NA 7.253 mg/L 3compartmentss NA 95% Human Human -DTXSID8044884 Css NA 0.9806 mg/L PBTK NA 50% Human Human -DTXSID8044884 Css NA 4.844 mg/L PBTK NA 95% Human Human -DTXSID8044884 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044884 Fup NA 0.692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044884 Vd NA 1.312 L/kg 1compartment NA NA Rat Human +DTXSID8044882 TK.Half.Life NA 0.6691 hours 1compartment NA NA Rat Human +DTXSID8044882 Css NA 0.005532 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044882 Css NA 0.0369 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044882 Css NA 0.00462 mg/L PBTK NA 50% Rat Human +DTXSID8044882 Css NA 0.02607 mg/L PBTK NA 95% Rat Human +DTXSID8044884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044884 Fup 0.652 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044884 Vd NA 0.9667 L/kg 1compartment NA NA Human Human +DTXSID8044884 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8044884 TK.Half.Life NA 0.8218 hours 1compartment NA NA Human Human +DTXSID8044884 Css NA 0.02981 mg/L 3compartmentss NA 50% Human Human +DTXSID8044884 Css NA 0.3236 mg/L 3compartmentss NA 95% Human Human +DTXSID8044884 Css NA 0.02477 mg/L PBTK NA 50% Human Human +DTXSID8044884 Css NA 0.2307 mg/L PBTK NA 95% Human Human +DTXSID8044884 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044884 Fup 0.652 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044884 Vd NA 0.9214 L/kg 1compartment NA NA Rat Human DTXSID8044884 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044884 TK.Half.Life NA 4.346 hours 1compartment NA NA Rat Human -DTXSID8044884 Css NA 0.2857 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044884 Css NA 1.794 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044884 Css NA 0.25 mg/L PBTK NA 50% Rat Human -DTXSID8044884 Css NA 1.104 mg/L PBTK NA 95% Rat Human -DTXSID8044886 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044886 Fup NA 0.0894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044886 Vd NA 0.4989 L/kg 1compartment NA NA Human Human -DTXSID8044886 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID8044886 TK.Half.Life NA 36.93 hours 1compartment NA NA Human Human -DTXSID8044886 Css NA 11.47 mg/L 3compartmentss NA 50% Human Human -DTXSID8044886 Css NA 53.44 mg/L 3compartmentss NA 95% Human Human -DTXSID8044886 Css NA 7.16 mg/L PBTK NA 50% Human Human -DTXSID8044886 Css NA 31.69 mg/L PBTK NA 95% Human Human -DTXSID8044886 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044886 Fup NA 0.0894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044886 Vd NA 0.4304 L/kg 1compartment NA NA Rat Human -DTXSID8044886 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8044886 TK.Half.Life NA 10.67 hours 1compartment NA NA Rat Human -DTXSID8044886 Css NA 3.292 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044886 Css NA 12.56 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044886 Css NA 1.922 mg/L PBTK NA 50% Rat Human -DTXSID8044886 Css NA 6.935 mg/L PBTK NA 95% Rat Human -DTXSID8044888 Clint NA 0.1736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044888 Fup NA 0.1972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044888 Vd NA 0.4442 L/kg 1compartment NA NA Human Human -DTXSID8044888 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8044888 TK.Half.Life NA 11.36 hours 1compartment NA NA Human Human -DTXSID8044888 Css NA 2.971 mg/L 3compartmentss NA 50% Human Human -DTXSID8044888 Css NA 11.38 mg/L 3compartmentss NA 95% Human Human -DTXSID8044888 Css NA 2.052 mg/L PBTK NA 50% Human Human -DTXSID8044888 Css NA 7.104 mg/L PBTK NA 95% Human Human -DTXSID8044888 Clint NA 0.1736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044888 Fup NA 0.1972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044888 Vd NA 0.4322 L/kg 1compartment NA NA Rat Human +DTXSID8044884 TK.Half.Life NA 0.3853 hours 1compartment NA NA Rat Human +DTXSID8044884 Css NA 0.00352 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044884 Css NA 0.03559 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044884 Css NA 0.002991 mg/L PBTK NA 50% Rat Human +DTXSID8044884 Css NA 0.02367 mg/L PBTK NA 95% Rat Human +DTXSID8044886 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044886 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044886 Vd NA 0.3982 L/kg 1compartment NA NA Human Human +DTXSID8044886 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8044886 TK.Half.Life NA 2.239 hours 1compartment NA NA Human Human +DTXSID8044886 Css NA 0.7772 mg/L 3compartmentss NA 50% Human Human +DTXSID8044886 Css NA 5.462 mg/L 3compartmentss NA 95% Human Human +DTXSID8044886 Css NA 0.4862 mg/L PBTK NA 50% Human Human +DTXSID8044886 Css NA 3.285 mg/L PBTK NA 95% Human Human +DTXSID8044886 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044886 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044886 Vd NA 0.3717 L/kg 1compartment NA NA Rat Human +DTXSID8044886 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8044886 TK.Half.Life NA 1.261 hours 1compartment NA NA Rat Human +DTXSID8044886 Css NA 0.09477 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044886 Css NA 0.4937 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044886 Css NA 0.05803 mg/L PBTK NA 50% Rat Human +DTXSID8044886 Css NA 0.2843 mg/L PBTK NA 95% Rat Human +DTXSID8044888 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044888 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044888 Vd NA 0.3753 L/kg 1compartment NA NA Human Human +DTXSID8044888 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8044888 TK.Half.Life NA 5.303 hours 1compartment NA NA Human Human +DTXSID8044888 Css NA 1.651 mg/L 3compartmentss NA 50% Human Human +DTXSID8044888 Css NA 7.446 mg/L 3compartmentss NA 95% Human Human +DTXSID8044888 Css NA 1.154 mg/L PBTK NA 50% Human Human +DTXSID8044888 Css NA 4.588 mg/L PBTK NA 95% Human Human +DTXSID8044888 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044888 Fup 0.458 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044888 Vd NA 0.3865 L/kg 1compartment NA NA Rat Human DTXSID8044888 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044888 TK.Half.Life NA 4.242 hours 1compartment NA NA Rat Human -DTXSID8044888 Css NA 0.9512 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044888 Css NA 2.977 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044888 Css NA 0.623 mg/L PBTK NA 50% Rat Human -DTXSID8044888 Css NA 1.731 mg/L PBTK NA 95% Rat Human -DTXSID8044911 Clint NA 11.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044911 Fup NA 0.0867 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044911 Vd NA 2.953 L/kg 1compartment NA NA Human Human -DTXSID8044911 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID8044911 TK.Half.Life NA 48.51 hours 1compartment NA NA Human Human -DTXSID8044911 Css NA 2.034 mg/L 3compartmentss NA 50% Human Human -DTXSID8044911 Css NA 12.53 mg/L 3compartmentss NA 95% Human Human -DTXSID8044911 Css NA 1.412 mg/L PBTK NA 50% Human Human -DTXSID8044911 Css NA 8.168 mg/L PBTK NA 95% Human Human -DTXSID8044911 Clint NA 11.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044911 Fup NA 0.0867 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044911 Vd NA 2.217 L/kg 1compartment NA NA Rat Human -DTXSID8044911 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID8044911 TK.Half.Life NA 8.205 hours 1compartment NA NA Rat Human -DTXSID8044911 Css NA 1.115 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044911 Css NA 5.234 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044911 Css NA 0.7389 mg/L PBTK NA 50% Rat Human -DTXSID8044911 Css NA 3.403 mg/L PBTK NA 95% Rat Human -DTXSID8044913 Clint NA 67.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044913 Fup NA 0.0915 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044913 Vd NA 2.358 L/kg 1compartment NA NA Human Human +DTXSID8044888 TK.Half.Life NA 1.86 hours 1compartment NA NA Rat Human +DTXSID8044888 Css NA 0.1052 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044888 Css NA 0.4006 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044888 Css NA 0.07204 mg/L PBTK NA 50% Rat Human +DTXSID8044888 Css NA 0.2393 mg/L PBTK NA 95% Rat Human +DTXSID8044913 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044913 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044913 Vd NA 3.527 L/kg 1compartment NA NA Human Human DTXSID8044913 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044913 TK.Half.Life NA 2.612 hours 1compartment NA NA Human Human -DTXSID8044913 Css NA 0.06124 mg/L 3compartmentss NA 50% Human Human -DTXSID8044913 Css NA 0.5679 mg/L 3compartmentss NA 95% Human Human -DTXSID8044913 Css NA 0.04959 mg/L PBTK NA 50% Human Human -DTXSID8044913 Css NA 0.4092 mg/L PBTK NA 95% Human Human -DTXSID8044913 Clint NA 67.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044913 Fup NA 0.0915 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044913 Vd NA 2.27 L/kg 1compartment NA NA Rat Human +DTXSID8044913 TK.Half.Life NA 6.102 hours 1compartment NA NA Human Human +DTXSID8044913 Css NA 0.1247 mg/L 3compartmentss NA 50% Human Human +DTXSID8044913 Css NA 0.9706 mg/L 3compartmentss NA 95% Human Human +DTXSID8044913 Css NA 0.1112 mg/L PBTK NA 50% Human Human +DTXSID8044913 Css NA 0.7747 mg/L PBTK NA 95% Human Human +DTXSID8044913 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044913 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044913 Vd NA 3.177 L/kg 1compartment NA NA Rat Human DTXSID8044913 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044913 TK.Half.Life NA 1.31 hours 1compartment NA NA Rat Human -DTXSID8044913 Css NA 0.03409 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044913 Css NA 0.2579 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044913 Css NA 0.02648 mg/L PBTK NA 50% Rat Human -DTXSID8044913 Css NA 0.1745 mg/L PBTK NA 95% Rat Human -DTXSID8044915 Clint NA 9.678 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044915 Fup NA 0.4684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044915 Vd NA 1.835 L/kg 1compartment NA NA Human Human +DTXSID8044913 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human +DTXSID8044913 Css NA 0.01558 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044913 Css NA 0.108 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044913 Css NA 0.0141 mg/L PBTK NA 50% Rat Human +DTXSID8044913 Css NA 0.0841 mg/L PBTK NA 95% Rat Human +DTXSID8044915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044915 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044915 Vd NA 1.272 L/kg 1compartment NA NA Human Human DTXSID8044915 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044915 TK.Half.Life NA 3.005 hours 1compartment NA NA Human Human -DTXSID8044915 Css NA 0.1156 mg/L 3compartmentss NA 50% Human Human -DTXSID8044915 Css NA 0.8251 mg/L 3compartmentss NA 95% Human Human -DTXSID8044915 Css NA 0.09561 mg/L PBTK NA 50% Human Human -DTXSID8044915 Css NA 0.5903 mg/L PBTK NA 95% Human Human -DTXSID8044915 Clint NA 9.678 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044915 Fup NA 0.4684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044915 Vd NA 1.51 L/kg 1compartment NA NA Rat Human +DTXSID8044915 TK.Half.Life NA 1.824 hours 1compartment NA NA Human Human +DTXSID8044915 Css NA 0.08312 mg/L 3compartmentss NA 50% Human Human +DTXSID8044915 Css NA 0.5933 mg/L 3compartmentss NA 95% Human Human +DTXSID8044915 Css NA 0.06128 mg/L PBTK NA 50% Human Human +DTXSID8044915 Css NA 0.4101 mg/L PBTK NA 95% Human Human +DTXSID8044915 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044915 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044915 Vd NA 1.052 L/kg 1compartment NA NA Rat Human DTXSID8044915 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044915 TK.Half.Life NA 1.165 hours 1compartment NA NA Rat Human -DTXSID8044915 Css NA 0.0597 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044915 Css NA 0.3271 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044915 Css NA 0.04813 mg/L PBTK NA 50% Rat Human -DTXSID8044915 Css NA 0.2255 mg/L PBTK NA 95% Rat Human -DTXSID8044919 Clint NA 1.778 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044919 Fup NA 0.1592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044919 Vd NA 0.4085 L/kg 1compartment NA NA Human Human +DTXSID8044915 TK.Half.Life NA 0.7693 hours 1compartment NA NA Rat Human +DTXSID8044915 Css NA 0.01028 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044915 Css NA 0.05708 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044915 Css NA 0.0076 mg/L PBTK NA 50% Rat Human +DTXSID8044915 Css NA 0.03825 mg/L PBTK NA 95% Rat Human +DTXSID8044919 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044919 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044919 Vd NA 1.292 L/kg 1compartment NA NA Human Human DTXSID8044919 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044919 TK.Half.Life NA 4.401 hours 1compartment NA NA Human Human -DTXSID8044919 Css NA 1.477 mg/L 3compartmentss NA 50% Human Human -DTXSID8044919 Css NA 7.778 mg/L 3compartmentss NA 95% Human Human -DTXSID8044919 Css NA 0.9429 mg/L PBTK NA 50% Human Human -DTXSID8044919 Css NA 4.673 mg/L PBTK NA 95% Human Human -DTXSID8044919 Clint NA 1.778 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044919 Fup NA 0.1592 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044919 Vd NA 0.3778 L/kg 1compartment NA NA Rat Human +DTXSID8044919 TK.Half.Life NA 2.664 hours 1compartment NA NA Human Human +DTXSID8044919 Css NA 0.1758 mg/L 3compartmentss NA 50% Human Human +DTXSID8044919 Css NA 1.377 mg/L 3compartmentss NA 95% Human Human +DTXSID8044919 Css NA 0.1196 mg/L PBTK NA 50% Human Human +DTXSID8044919 Css NA 0.8891 mg/L PBTK NA 95% Human Human +DTXSID8044919 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044919 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044919 Vd NA 1.004 L/kg 1compartment NA NA Rat Human DTXSID8044919 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044919 TK.Half.Life NA 2.191 hours 1compartment NA NA Rat Human -DTXSID8044919 Css NA 0.6724 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044919 Css NA 2.666 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044919 Css NA 0.4034 mg/L PBTK NA 50% Rat Human -DTXSID8044919 Css NA 1.493 mg/L PBTK NA 95% Rat Human -DTXSID8044961 Clint 0.5757 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID8044961 Fup NA 0.2212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044961 Vd NA 2.286 L/kg 1compartment NA NA Human Human -DTXSID8044961 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8044961 TK.Half.Life NA 36.1 hours 1compartment NA NA Human Human -DTXSID8044961 Css NA 1.431 mg/L 3compartmentss NA 50% Human Human -DTXSID8044961 Css NA 6.335 mg/L 3compartmentss NA 95% Human Human -DTXSID8044961 Css NA 1.288 mg/L PBTK NA 50% Human Human -DTXSID8044961 Css NA 4.553 mg/L PBTK NA 95% Human Human -DTXSID8044961 Clint 0.5757 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID8044961 Fup NA 0.2212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044961 Vd NA 2.206 L/kg 1compartment NA NA Rat Human -DTXSID8044961 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8044961 TK.Half.Life NA 14.92 hours 1compartment NA NA Rat Human -DTXSID8044961 Css NA 0.5322 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044961 Css NA 1.973 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044961 Css NA 0.4655 mg/L PBTK NA 50% Rat Human -DTXSID8044961 Css NA 1.314 mg/L PBTK NA 95% Rat Human -DTXSID8044963 Clint NA 0.1826 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044963 Fup NA 0.1251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044963 Vd NA 0.261 L/kg 1compartment NA NA Human Human -DTXSID8044963 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8044963 TK.Half.Life NA 10.39 hours 1compartment NA NA Human Human -DTXSID8044963 Css NA 5.992 mg/L 3compartmentss NA 50% Human Human -DTXSID8044963 Css NA 28.54 mg/L 3compartmentss NA 95% Human Human -DTXSID8044963 Css NA 3.698 mg/L PBTK NA 50% Human Human -DTXSID8044963 Css NA 16.72 mg/L PBTK NA 95% Human Human -DTXSID8044963 Clint NA 0.1826 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044963 Fup NA 0.1251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044963 Vd NA 0.2584 L/kg 1compartment NA NA Rat Human +DTXSID8044919 TK.Half.Life NA 1.068 hours 1compartment NA NA Rat Human +DTXSID8044919 Css NA 0.02274 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044919 Css NA 0.1327 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044919 Css NA 0.01521 mg/L PBTK NA 50% Rat Human +DTXSID8044919 Css NA 0.08305 mg/L PBTK NA 95% Rat Human +DTXSID8044963 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044963 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044963 Vd NA 0.3644 L/kg 1compartment NA NA Human Human +DTXSID8044963 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8044963 TK.Half.Life NA 0.9082 hours 1compartment NA NA Human Human +DTXSID8044963 Css NA 0.2266 mg/L 3compartmentss NA 50% Human Human +DTXSID8044963 Css NA 1.388 mg/L 3compartmentss NA 95% Human Human +DTXSID8044963 Css NA 0.1518 mg/L PBTK NA 50% Human Human +DTXSID8044963 Css NA 0.8787 mg/L PBTK NA 95% Human Human +DTXSID8044963 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044963 Fup 0.315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044963 Vd NA 0.3653 L/kg 1compartment NA NA Rat Human DTXSID8044963 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044963 TK.Half.Life NA 3.972 hours 1compartment NA NA Rat Human -DTXSID8044963 Css NA 1.964 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044963 Css NA 7.822 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044963 Css NA 1.129 mg/L PBTK NA 50% Rat Human -DTXSID8044963 Css NA 4.297 mg/L PBTK NA 95% Rat Human -DTXSID8044967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044967 Fup NA 0.9665 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8044967 Vd NA 0.8285 L/kg 1compartment NA NA Human Human +DTXSID8044963 TK.Half.Life NA 0.5154 hours 1compartment NA NA Rat Human +DTXSID8044963 Css NA 0.02673 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044963 Css NA 0.1235 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044963 Css NA 0.0176 mg/L PBTK NA 50% Rat Human +DTXSID8044963 Css NA 0.0741 mg/L PBTK NA 95% Rat Human +DTXSID8044967 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044967 Fup 0.879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8044967 Vd NA 0.7636 L/kg 1compartment NA NA Human Human DTXSID8044967 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8044967 TK.Half.Life NA 5.554 hours 1compartment NA NA Human Human -DTXSID8044967 Css NA 0.8752 mg/L 3compartmentss NA 50% Human Human -DTXSID8044967 Css NA 4.806 mg/L 3compartmentss NA 95% Human Human -DTXSID8044967 Css NA 0.74 mg/L PBTK NA 50% Human Human -DTXSID8044967 Css NA 3.203 mg/L PBTK NA 95% Human Human -DTXSID8044967 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044967 Fup NA 0.9665 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8044967 Vd NA 0.8577 L/kg 1compartment NA NA Rat Human +DTXSID8044967 TK.Half.Life NA 5.626 hours 1compartment NA NA Human Human +DTXSID8044967 Css NA 0.9018 mg/L 3compartmentss NA 50% Human Human +DTXSID8044967 Css NA 5.419 mg/L 3compartmentss NA 95% Human Human +DTXSID8044967 Css NA 0.7491 mg/L PBTK NA 50% Human Human +DTXSID8044967 Css NA 3.496 mg/L PBTK NA 95% Human Human +DTXSID8044967 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044967 Fup 0.879 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8044967 Vd NA 0.7934 L/kg 1compartment NA NA Rat Human DTXSID8044967 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8044967 TK.Half.Life NA 1.957 hours 1compartment NA NA Rat Human -DTXSID8044967 Css NA 0.2218 mg/L 3compartmentss NA 50% Rat Human -DTXSID8044967 Css NA 1.2 mg/L 3compartmentss NA 95% Rat Human -DTXSID8044967 Css NA 0.1829 mg/L PBTK NA 50% Rat Human -DTXSID8044967 Css NA 0.7335 mg/L PBTK NA 95% Rat Human -DTXSID8045141 Clint NA 339.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045141 Fup NA 0.3245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045141 Vd NA 1.729 L/kg 1compartment NA NA Human Human +DTXSID8044967 TK.Half.Life NA 1.991 hours 1compartment NA NA Rat Human +DTXSID8044967 Css NA 0.0535 mg/L 3compartmentss NA 50% Rat Human +DTXSID8044967 Css NA 0.3066 mg/L 3compartmentss NA 95% Rat Human +DTXSID8044967 Css NA 0.04475 mg/L PBTK NA 50% Rat Human +DTXSID8044967 Css NA 0.1914 mg/L PBTK NA 95% Rat Human +DTXSID8045141 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045141 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045141 Vd NA 1.684 L/kg 1compartment NA NA Human Human DTXSID8045141 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045141 TK.Half.Life NA 1.231 hours 1compartment NA NA Human Human -DTXSID8045141 Css NA 0.004454 mg/L 3compartmentss NA 50% Human Human -DTXSID8045141 Css NA 0.03442 mg/L 3compartmentss NA 95% Human Human -DTXSID8045141 Css NA 0.0036 mg/L PBTK NA 50% Human Human -DTXSID8045141 Css NA 0.02528 mg/L PBTK NA 95% Human Human -DTXSID8045141 Clint NA 339.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045141 Fup NA 0.3245 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045141 Vd NA 1.5 L/kg 1compartment NA NA Rat Human +DTXSID8045141 TK.Half.Life NA 3.582 hours 1compartment NA NA Human Human +DTXSID8045141 Css NA 0.1603 mg/L 3compartmentss NA 50% Human Human +DTXSID8045141 Css NA 1.123 mg/L 3compartmentss NA 95% Human Human +DTXSID8045141 Css NA 0.1348 mg/L PBTK NA 50% Human Human +DTXSID8045141 Css NA 0.8116 mg/L PBTK NA 95% Human Human +DTXSID8045141 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045141 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045141 Vd NA 1.502 L/kg 1compartment NA NA Rat Human DTXSID8045141 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045141 TK.Half.Life NA 0.4709 hours 1compartment NA NA Rat Human -DTXSID8045141 Css NA 0.00244 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045141 Css NA 0.01641 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045141 Css NA 0.00191 mg/L PBTK NA 50% Rat Human -DTXSID8045141 Css NA 0.01149 mg/L PBTK NA 95% Rat Human -DTXSID8045145 Clint NA 18.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045145 Fup NA 0.1054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045145 Vd NA 2.802 L/kg 1compartment NA NA Human Human +DTXSID8045141 TK.Half.Life NA 1.665 hours 1compartment NA NA Rat Human +DTXSID8045141 Css NA 0.01881 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045141 Css NA 0.09569 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045141 Css NA 0.01591 mg/L PBTK NA 50% Rat Human +DTXSID8045141 Css NA 0.06718 mg/L PBTK NA 95% Rat Human +DTXSID8045145 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045145 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045145 Vd NA 3.729 L/kg 1compartment NA NA Human Human DTXSID8045145 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045145 TK.Half.Life NA 3.447 hours 1compartment NA NA Human Human -DTXSID8045145 Css NA 0.07782 mg/L 3compartmentss NA 50% Human Human -DTXSID8045145 Css NA 0.7491 mg/L 3compartmentss NA 95% Human Human -DTXSID8045145 Css NA 0.07647 mg/L PBTK NA 50% Human Human -DTXSID8045145 Css NA 0.6062 mg/L PBTK NA 95% Human Human -DTXSID8045145 Clint NA 18.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045145 Fup NA 0.1054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045145 Vd NA 2.766 L/kg 1compartment NA NA Rat Human +DTXSID8045145 TK.Half.Life NA 3.141 hours 1compartment NA NA Human Human +DTXSID8045145 Css NA 0.02818 mg/L 3compartmentss NA 50% Human Human +DTXSID8045145 Css NA 0.2749 mg/L 3compartmentss NA 95% Human Human +DTXSID8045145 Css NA 0.03642 mg/L PBTK NA 50% Human Human +DTXSID8045145 Css NA 0.2762 mg/L PBTK NA 95% Human Human +DTXSID8045145 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045145 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045145 Vd NA 3.722 L/kg 1compartment NA NA Rat Human DTXSID8045145 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045145 TK.Half.Life NA 1.944 hours 1compartment NA NA Rat Human -DTXSID8045145 Css NA 0.04232 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045145 Css NA 0.3454 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045145 Css NA 0.04102 mg/L PBTK NA 50% Rat Human -DTXSID8045145 Css NA 0.2603 mg/L PBTK NA 95% Rat Human -DTXSID8045147 Clint NA 5.763 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8045145 TK.Half.Life NA 1.746 hours 1compartment NA NA Rat Human +DTXSID8045145 Css NA 0.003497 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045145 Css NA 0.02491 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045145 Css NA 0.004726 mg/L PBTK NA 50% Rat Human +DTXSID8045145 Css NA 0.02549 mg/L PBTK NA 95% Rat Human +DTXSID8045147 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID8045147 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8045147 Vd NA 0.6749 L/kg 1compartment NA NA Human Human +DTXSID8045147 Vd NA 0.6715 L/kg 1compartment NA NA Human Human DTXSID8045147 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045147 TK.Half.Life NA 1.813 hours 1compartment NA NA Human Human -DTXSID8045147 Css NA 0.25 mg/L 3compartmentss NA 50% Human Human -DTXSID8045147 Css NA 1.489 mg/L 3compartmentss NA 95% Human Human -DTXSID8045147 Css NA 0.1804 mg/L PBTK NA 50% Human Human -DTXSID8045147 Css NA 0.964 mg/L PBTK NA 95% Human Human -DTXSID8045147 Clint NA 5.763 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8045147 TK.Half.Life NA 2.301 hours 1compartment NA NA Human Human +DTXSID8045147 Css NA 0.3315 mg/L 3compartmentss NA 50% Human Human +DTXSID8045147 Css NA 1.939 mg/L 3compartmentss NA 95% Human Human +DTXSID8045147 Css NA 0.236 mg/L PBTK NA 50% Human Human +DTXSID8045147 Css NA 1.259 mg/L PBTK NA 95% Human Human +DTXSID8045147 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID8045147 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8045147 Vd NA 0.6257 L/kg 1compartment NA NA Rat Human +DTXSID8045147 Vd NA 0.6229 L/kg 1compartment NA NA Rat Human DTXSID8045147 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045147 TK.Half.Life NA 0.9509 hours 1compartment NA NA Rat Human -DTXSID8045147 Css NA 0.127 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045147 Css NA 0.5663 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045147 Css NA 0.0873 mg/L PBTK NA 50% Rat Human -DTXSID8045147 Css NA 0.3456 mg/L PBTK NA 95% Rat Human +DTXSID8045147 TK.Half.Life NA 1.199 hours 1compartment NA NA Rat Human +DTXSID8045147 Css NA 0.03752 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045147 Css NA 0.1639 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045147 Css NA 0.02668 mg/L PBTK NA 50% Rat Human +DTXSID8045147 Css NA 0.1019 mg/L PBTK NA 95% Rat Human DTXSID8045149 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID8045149 Fup NA 0.4469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045149 Vd NA 3.774 L/kg 1compartment NA NA Human Human +DTXSID8045149 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045149 Vd NA 3.135 L/kg 1compartment NA NA Human Human DTXSID8045149 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045149 TK.Half.Life NA 9.801 hours 1compartment NA NA Human Human -DTXSID8045149 Css NA 0.163 mg/L 3compartmentss NA 50% Human Human -DTXSID8045149 Css NA 1.241 mg/L 3compartmentss NA 95% Human Human -DTXSID8045149 Css NA 0.2069 mg/L PBTK NA 50% Human Human -DTXSID8045149 Css NA 1.089 mg/L PBTK NA 95% Human Human +DTXSID8045149 TK.Half.Life NA 10.02 hours 1compartment NA NA Human Human +DTXSID8045149 Css NA 0.2132 mg/L 3compartmentss NA 50% Human Human +DTXSID8045149 Css NA 1.439 mg/L 3compartmentss NA 95% Human Human +DTXSID8045149 Css NA 0.2392 mg/L PBTK NA 50% Human Human +DTXSID8045149 Css NA 1.226 mg/L PBTK NA 95% Human Human DTXSID8045149 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID8045149 Fup NA 0.4469 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045149 Vd NA 3.841 L/kg 1compartment NA NA Rat Human +DTXSID8045149 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045149 Vd NA 3.176 L/kg 1compartment NA NA Rat Human DTXSID8045149 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045149 TK.Half.Life NA 5.59 hours 1compartment NA NA Rat Human -DTXSID8045149 Css NA 0.07222 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045149 Css NA 0.4676 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045149 Css NA 0.09388 mg/L PBTK NA 50% Rat Human -DTXSID8045149 Css NA 0.3759 mg/L PBTK NA 95% Rat Human +DTXSID8045149 TK.Half.Life NA 5.743 hours 1compartment NA NA Rat Human +DTXSID8045149 Css NA 0.0227 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045149 Css NA 0.1236 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045149 Css NA 0.0265 mg/L PBTK NA 50% Rat Human +DTXSID8045149 Css NA 0.0988 mg/L PBTK NA 95% Rat Human DTXSID8045191 Clint 1.324 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8045191 Fup 0.95 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8045191 Vd NA 2.248 L/kg 1compartment NA NA Human Human DTXSID8045191 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8045191 TK.Half.Life NA 5.357 hours 1compartment NA NA Human Human -DTXSID8045191 Css NA 0.162 mg/L 3compartmentss NA 50% Human Human -DTXSID8045191 Css NA 1.012 mg/L 3compartmentss NA 95% Human Human -DTXSID8045191 Css NA 0.1476 mg/L PBTK NA 50% Human Human -DTXSID8045191 Css NA 0.7168 mg/L PBTK NA 95% Human Human +DTXSID8045191 Css NA 0.1478 mg/L 3compartmentss NA 50% Human Human +DTXSID8045191 Css NA 0.7678 mg/L 3compartmentss NA 95% Human Human +DTXSID8045191 Css NA 0.1511 mg/L PBTK NA 50% Human Human +DTXSID8045191 Css NA 0.79 mg/L PBTK NA 95% Human Human DTXSID8045191 Clint 1.324 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID8045191 Fup 0.95 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8045191 Vd NA 1.971 L/kg 1compartment NA NA Rat Human DTXSID8045191 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8045191 TK.Half.Life NA 2.856 hours 1compartment NA NA Rat Human -DTXSID8045191 Css NA 0.1091 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045191 Css NA 0.8061 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045191 Css NA 0.1037 mg/L PBTK NA 50% Rat Human -DTXSID8045191 Css NA 0.5094 mg/L PBTK NA 95% Rat Human +DTXSID8045191 Css NA 0.001557 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045191 Css NA 0.01138 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045191 Css NA 0.001608 mg/L PBTK NA 50% Rat Human +DTXSID8045191 Css NA 0.01183 mg/L PBTK NA 95% Rat Human DTXSID8045193 Clint 10.9 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8045193 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8045193 Vd NA 3.021 L/kg 1compartment NA NA Human Human -DTXSID8045193 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8045193 TK.Half.Life NA 20.8 hours 1compartment NA NA Human Human -DTXSID8045193 Css NA 0.963 mg/L 3compartmentss NA 50% Human Human -DTXSID8045193 Css NA 5.632 mg/L 3compartmentss NA 95% Human Human -DTXSID8045193 Css NA 0.5845 mg/L PBTK NA 50% Human Human -DTXSID8045193 Css NA 3.29 mg/L PBTK NA 95% Human Human +DTXSID8045193 Vd NA 2.129 L/kg 1compartment NA NA Human Human +DTXSID8045193 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045193 TK.Half.Life NA 9.137 hours 1compartment NA NA Human Human +DTXSID8045193 Css NA 0.5297 mg/L 3compartmentss NA 50% Human Human +DTXSID8045193 Css NA 3.616 mg/L 3compartmentss NA 95% Human Human +DTXSID8045193 Css NA 0.3544 mg/L PBTK NA 50% Human Human +DTXSID8045193 Css NA 2.422 mg/L PBTK NA 95% Human Human DTXSID8045193 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8045193 Fup 0.12 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat -DTXSID8045193 Vd NA 2.499 L/kg 1compartment NA NA Rat Rat -DTXSID8045193 Days.Css NA 45 Days PBTK NA NA Rat Rat -DTXSID8045193 TK.Half.Life NA 80.91 hours 1compartment NA NA Rat Rat -DTXSID8045193 Css NA 8.938 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8045193 Css NA 20.77 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8045193 Css NA 5.051 mg/L PBTK NA 50% Rat Rat -DTXSID8045193 Css NA 11.45 mg/L PBTK NA 95% Rat Rat -DTXSID8045195 Clint NA 9.177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8045193 Vd NA 2.03 L/kg 1compartment NA NA Rat Rat +DTXSID8045193 Days.Css NA 9 Days PBTK NA NA Rat Rat +DTXSID8045193 TK.Half.Life NA 40.94 hours 1compartment NA NA Rat Rat +DTXSID8045193 Css NA 0.6192 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8045193 Css NA 1.921 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8045193 Css NA 0.4296 mg/L PBTK NA 50% Rat Rat +DTXSID8045193 Css NA 1.333 mg/L PBTK NA 95% Rat Rat +DTXSID8045195 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8045195 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID8045195 Vd NA 2.835 L/kg 1compartment NA NA Human Human DTXSID8045195 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045195 TK.Half.Life NA 6.545 hours 1compartment NA NA Human Human -DTXSID8045195 Css NA 0.1926 mg/L 3compartmentss NA 50% Human Human -DTXSID8045195 Css NA 1.272 mg/L 3compartmentss NA 95% Human Human -DTXSID8045195 Css NA 0.1591 mg/L PBTK NA 50% Human Human -DTXSID8045195 Css NA 0.9562 mg/L PBTK NA 95% Human Human -DTXSID8045195 Clint NA 9.177 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8045195 TK.Half.Life NA 3.892 hours 1compartment NA NA Human Human +DTXSID8045195 Css NA 0.08052 mg/L 3compartmentss NA 50% Human Human +DTXSID8045195 Css NA 0.6379 mg/L 3compartmentss NA 95% Human Human +DTXSID8045195 Css NA 0.06692 mg/L PBTK NA 50% Human Human +DTXSID8045195 Css NA 0.4719 mg/L PBTK NA 95% Human Human +DTXSID8045195 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8045195 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID8045195 Vd NA 2.266 L/kg 1compartment NA NA Rat Human DTXSID8045195 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045195 TK.Half.Life NA 1.781 hours 1compartment NA NA Rat Human -DTXSID8045195 Css NA 0.09944 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045195 Css NA 0.5076 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045195 Css NA 0.0806 mg/L PBTK NA 50% Rat Human -DTXSID8045195 Css NA 0.3599 mg/L PBTK NA 95% Rat Human -DTXSID8045220 Clint NA 19.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045220 Fup NA 0.2357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045220 Vd NA 0.8865 L/kg 1compartment NA NA Human Human +DTXSID8045195 TK.Half.Life NA 1.144 hours 1compartment NA NA Rat Human +DTXSID8045195 Css NA 0.009889 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045195 Css NA 0.06284 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045195 Css NA 0.008288 mg/L PBTK NA 50% Rat Human +DTXSID8045195 Css NA 0.0478 mg/L PBTK NA 95% Rat Human +DTXSID8045220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045220 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045220 Vd NA 0.7389 L/kg 1compartment NA NA Human Human DTXSID8045220 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045220 TK.Half.Life NA 1.397 hours 1compartment NA NA Human Human -DTXSID8045220 Css NA 0.1047 mg/L 3compartmentss NA 50% Human Human -DTXSID8045220 Css NA 0.7 mg/L 3compartmentss NA 95% Human Human -DTXSID8045220 Css NA 0.07413 mg/L PBTK NA 50% Human Human -DTXSID8045220 Css NA 0.4671 mg/L PBTK NA 95% Human Human -DTXSID8045220 Clint NA 19.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045220 Fup NA 0.2357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045220 Vd NA 0.76 L/kg 1compartment NA NA Rat Human +DTXSID8045220 TK.Half.Life NA 1.05 hours 1compartment NA NA Human Human +DTXSID8045220 Css NA 0.07951 mg/L 3compartmentss NA 50% Human Human +DTXSID8045220 Css NA 0.5859 mg/L 3compartmentss NA 95% Human Human +DTXSID8045220 Css NA 0.05635 mg/L PBTK NA 50% Human Human +DTXSID8045220 Css NA 0.3877 mg/L PBTK NA 95% Human Human +DTXSID8045220 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045220 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045220 Vd NA 0.6601 L/kg 1compartment NA NA Rat Human DTXSID8045220 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045220 TK.Half.Life NA 0.643 hours 1compartment NA NA Rat Human -DTXSID8045220 Css NA 0.05712 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045220 Css NA 0.2955 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045220 Css NA 0.03872 mg/L PBTK NA 50% Rat Human -DTXSID8045220 Css NA 0.1866 mg/L PBTK NA 95% Rat Human -DTXSID8045222 Clint NA 14.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8045220 TK.Half.Life NA 0.5005 hours 1compartment NA NA Rat Human +DTXSID8045220 Css NA 0.01029 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045220 Css NA 0.05642 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045220 Css NA 0.007186 mg/L PBTK NA 50% Rat Human +DTXSID8045220 Css NA 0.03675 mg/L PBTK NA 95% Rat Human +DTXSID8045222 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8045222 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8045222 Vd NA 2.532 L/kg 1compartment NA NA Human Human -DTXSID8045222 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045222 TK.Half.Life NA 1.65 hours 1compartment NA NA Human Human -DTXSID8045222 Css NA 0.0299 mg/L 3compartmentss NA 50% Human Human -DTXSID8045222 Css NA 0.3102 mg/L 3compartmentss NA 95% Human Human -DTXSID8045222 Css NA 0.03186 mg/L PBTK NA 50% Human Human -DTXSID8045222 Css NA 0.2589 mg/L PBTK NA 95% Human Human -DTXSID8045222 Clint NA 14.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8045222 Vd NA 2.54 L/kg 1compartment NA NA Human Human +DTXSID8045222 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8045222 TK.Half.Life NA 16.94 hours 1compartment NA NA Human Human +DTXSID8045222 Css NA 0.5814 mg/L 3compartmentss NA 50% Human Human +DTXSID8045222 Css NA 3.968 mg/L 3compartmentss NA 95% Human Human +DTXSID8045222 Css NA 0.6397 mg/L PBTK NA 50% Human Human +DTXSID8045222 Css NA 2.89 mg/L PBTK NA 95% Human Human +DTXSID8045222 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8045222 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8045222 Vd NA 2.577 L/kg 1compartment NA NA Rat Human +DTXSID8045222 Vd NA 2.585 L/kg 1compartment NA NA Rat Human DTXSID8045222 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045222 TK.Half.Life NA 0.8596 hours 1compartment NA NA Rat Human -DTXSID8045222 Css NA 0.0146 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045222 Css NA 0.1293 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045222 Css NA 0.0159 mg/L PBTK NA 50% Rat Human -DTXSID8045222 Css NA 0.09859 mg/L PBTK NA 95% Rat Human -DTXSID8045224 Clint NA 0.7706 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045224 Fup NA 0.034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045224 Vd NA 0.2645 L/kg 1compartment NA NA Human Human -DTXSID8045224 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8045224 TK.Half.Life NA 22.03 hours 1compartment NA NA Human Human -DTXSID8045224 Css NA 15.1 mg/L 3compartmentss NA 50% Human Human -DTXSID8045224 Css NA 72.88 mg/L 3compartmentss NA 95% Human Human -DTXSID8045224 Css NA 8.964 mg/L PBTK NA 50% Human Human -DTXSID8045224 Css NA 41.59 mg/L PBTK NA 95% Human Human -DTXSID8045224 Clint NA 0.7706 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045224 Fup NA 0.034 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045224 Vd NA 0.2469 L/kg 1compartment NA NA Rat Human -DTXSID8045224 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8045224 TK.Half.Life NA 9.842 hours 1compartment NA NA Rat Human -DTXSID8045224 Css NA 6.061 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045224 Css NA 25.04 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045224 Css NA 3.348 mg/L PBTK NA 50% Rat Human -DTXSID8045224 Css NA 13.6 mg/L PBTK NA 95% Rat Human -DTXSID8045228 Clint NA 12.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045228 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045228 Vd NA 0.4399 L/kg 1compartment NA NA Human Human +DTXSID8045222 TK.Half.Life NA 5.879 hours 1compartment NA NA Rat Human +DTXSID8045222 Css NA 0.01476 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045222 Css NA 0.1053 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045222 Css NA 0.01596 mg/L PBTK NA 50% Rat Human +DTXSID8045222 Css NA 0.08077 mg/L PBTK NA 95% Rat Human +DTXSID8045224 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045224 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045224 Vd NA 0.8108 L/kg 1compartment NA NA Human Human +DTXSID8045224 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045224 TK.Half.Life NA 1.812 hours 1compartment NA NA Human Human +DTXSID8045224 Css NA 0.1822 mg/L 3compartmentss NA 50% Human Human +DTXSID8045224 Css NA 1.211 mg/L 3compartmentss NA 95% Human Human +DTXSID8045224 Css NA 0.1357 mg/L PBTK NA 50% Human Human +DTXSID8045224 Css NA 0.8027 mg/L PBTK NA 95% Human Human +DTXSID8045224 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045224 Fup 0.355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045224 Vd NA 0.7546 L/kg 1compartment NA NA Rat Human +DTXSID8045224 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8045224 TK.Half.Life NA 0.9399 hours 1compartment NA NA Rat Human +DTXSID8045224 Css NA 0.02158 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045224 Css NA 0.1058 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045224 Css NA 0.016 mg/L PBTK NA 50% Rat Human +DTXSID8045224 Css NA 0.06806 mg/L PBTK NA 95% Rat Human +DTXSID8045228 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045228 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045228 Vd NA 0.401 L/kg 1compartment NA NA Human Human DTXSID8045228 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045228 TK.Half.Life NA 6.558 hours 1compartment NA NA Human Human -DTXSID8045228 Css NA 2.513 mg/L 3compartmentss NA 50% Human Human -DTXSID8045228 Css NA 24.31 mg/L 3compartmentss NA 95% Human Human -DTXSID8045228 Css NA 1.575 mg/L PBTK NA 50% Human Human -DTXSID8045228 Css NA 14.24 mg/L PBTK NA 95% Human Human -DTXSID8045228 Clint NA 12.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045228 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045228 Vd NA 0.4064 L/kg 1compartment NA NA Rat Human +DTXSID8045228 TK.Half.Life NA 2.766 hours 1compartment NA NA Human Human +DTXSID8045228 Css NA 0.5612 mg/L 3compartmentss NA 50% Human Human +DTXSID8045228 Css NA 6.263 mg/L 3compartmentss NA 95% Human Human +DTXSID8045228 Css NA 0.3519 mg/L PBTK NA 50% Human Human +DTXSID8045228 Css NA 3.752 mg/L PBTK NA 95% Human Human +DTXSID8045228 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045228 Fup 0.0284 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045228 Vd NA 0.3821 L/kg 1compartment NA NA Rat Human DTXSID8045228 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045228 TK.Half.Life NA 3.95 hours 1compartment NA NA Rat Human -DTXSID8045228 Css NA 1.412 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045228 Css NA 10.83 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045228 Css NA 0.8271 mg/L PBTK NA 50% Rat Human -DTXSID8045228 Css NA 6.077 mg/L PBTK NA 95% Rat Human -DTXSID8045305 Clint NA 6.887 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045305 Fup NA 0.0515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045305 Vd NA 0.2808 L/kg 1compartment NA NA Human Human -DTXSID8045305 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045305 TK.Half.Life NA 3.066 hours 1compartment NA NA Human Human -DTXSID8045305 Css NA 1.853 mg/L 3compartmentss NA 50% Human Human -DTXSID8045305 Css NA 12.81 mg/L 3compartmentss NA 95% Human Human -DTXSID8045305 Css NA 1.121 mg/L PBTK NA 50% Human Human -DTXSID8045305 Css NA 7.553 mg/L PBTK NA 95% Human Human -DTXSID8045305 Clint NA 6.887 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045305 Fup NA 0.0515 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045305 Vd NA 0.2752 L/kg 1compartment NA NA Rat Human -DTXSID8045305 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045305 TK.Half.Life NA 1.885 hours 1compartment NA NA Rat Human -DTXSID8045305 Css NA 0.9801 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045305 Css NA 5.407 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045305 Css NA 0.5598 mg/L PBTK NA 50% Rat Human -DTXSID8045305 Css NA 2.978 mg/L PBTK NA 95% Rat Human -DTXSID8045307 Clint NA 1.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045307 Fup NA 0.0761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045307 Vd NA 0.4122 L/kg 1compartment NA NA Human Human -DTXSID8045307 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045307 TK.Half.Life NA 8.923 hours 1compartment NA NA Human Human -DTXSID8045307 Css NA 3.485 mg/L 3compartmentss NA 50% Human Human -DTXSID8045307 Css NA 18.99 mg/L 3compartmentss NA 95% Human Human -DTXSID8045307 Css NA 2.188 mg/L PBTK NA 50% Human Human -DTXSID8045307 Css NA 11.26 mg/L PBTK NA 95% Human Human -DTXSID8045307 Clint NA 1.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045307 Fup NA 0.0761 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045307 Vd NA 0.3665 L/kg 1compartment NA NA Rat Human +DTXSID8045228 TK.Half.Life NA 1.708 hours 1compartment NA NA Rat Human +DTXSID8045228 Css NA 0.006344 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045228 Css NA 0.05846 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045228 Css NA 0.00374 mg/L PBTK NA 50% Rat Human +DTXSID8045228 Css NA 0.03287 mg/L PBTK NA 95% Rat Human +DTXSID8045305 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045305 Fup 0.0672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045305 Vd NA 0.3375 L/kg 1compartment NA NA Human Human +DTXSID8045305 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID8045305 TK.Half.Life NA 32.5 hours 1compartment NA NA Human Human +DTXSID8045305 Css NA 14.08 mg/L 3compartmentss NA 50% Human Human +DTXSID8045305 Css NA 58.05 mg/L 3compartmentss NA 95% Human Human +DTXSID8045305 Css NA 8.817 mg/L PBTK NA 50% Human Human +DTXSID8045305 Css NA 34.94 mg/L PBTK NA 95% Human Human +DTXSID8045305 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045305 Fup 0.0672 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045305 Vd NA 0.33 L/kg 1compartment NA NA Rat Human +DTXSID8045305 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8045305 TK.Half.Life NA 10.83 hours 1compartment NA NA Rat Human +DTXSID8045305 Css NA 0.93 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045305 Css NA 3.141 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045305 Css NA 0.5658 mg/L PBTK NA 50% Rat Human +DTXSID8045305 Css NA 1.805 mg/L PBTK NA 95% Rat Human +DTXSID8045307 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045307 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045307 Vd NA 0.5347 L/kg 1compartment NA NA Human Human +DTXSID8045307 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8045307 TK.Half.Life NA 27.19 hours 1compartment NA NA Human Human +DTXSID8045307 Css NA 7.032 mg/L 3compartmentss NA 50% Human Human +DTXSID8045307 Css NA 33.08 mg/L 3compartmentss NA 95% Human Human +DTXSID8045307 Css NA 4.642 mg/L PBTK NA 50% Human Human +DTXSID8045307 Css NA 19.94 mg/L PBTK NA 95% Human Human +DTXSID8045307 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045307 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045307 Vd NA 0.4749 L/kg 1compartment NA NA Rat Human DTXSID8045307 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045307 TK.Half.Life NA 4.327 hours 1compartment NA NA Rat Human -DTXSID8045307 Css NA 1.621 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045307 Css NA 6.886 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045307 Css NA 0.9522 mg/L PBTK NA 50% Rat Human -DTXSID8045307 Css NA 3.815 mg/L PBTK NA 95% Rat Human -DTXSID8045351 Clint NA 8.433 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045351 Fup NA 0.1156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045351 Vd NA 0.2377 L/kg 1compartment NA NA Human Human +DTXSID8045307 TK.Half.Life NA 8.098 hours 1compartment NA NA Rat Human +DTXSID8045307 Css NA 0.4548 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045307 Css NA 1.829 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045307 Css NA 0.2928 mg/L PBTK NA 50% Rat Human +DTXSID8045307 Css NA 1.066 mg/L PBTK NA 95% Rat Human +DTXSID8045351 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045351 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045351 Vd NA 0.2805 L/kg 1compartment NA NA Human Human DTXSID8045351 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045351 TK.Half.Life NA 1.079 hours 1compartment NA NA Human Human -DTXSID8045351 Css NA 0.6402 mg/L 3compartmentss NA 50% Human Human -DTXSID8045351 Css NA 4.432 mg/L 3compartmentss NA 95% Human Human -DTXSID8045351 Css NA 0.3898 mg/L PBTK NA 50% Human Human -DTXSID8045351 Css NA 2.621 mg/L PBTK NA 95% Human Human -DTXSID8045351 Clint NA 8.433 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045351 Fup NA 0.1156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045351 Vd NA 0.2382 L/kg 1compartment NA NA Rat Human +DTXSID8045351 TK.Half.Life NA 1.042 hours 1compartment NA NA Human Human +DTXSID8045351 Css NA 0.3878 mg/L 3compartmentss NA 50% Human Human +DTXSID8045351 Css NA 2.275 mg/L 3compartmentss NA 95% Human Human +DTXSID8045351 Css NA 0.2468 mg/L PBTK NA 50% Human Human +DTXSID8045351 Css NA 1.374 mg/L PBTK NA 95% Human Human +DTXSID8045351 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045351 Fup 0.191 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045351 Vd NA 0.2822 L/kg 1compartment NA NA Rat Human DTXSID8045351 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045351 TK.Half.Life NA 0.657 hours 1compartment NA NA Rat Human -DTXSID8045351 Css NA 0.3477 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045351 Css NA 1.783 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045351 Css NA 0.1975 mg/L PBTK NA 50% Rat Human -DTXSID8045351 Css NA 0.9839 mg/L PBTK NA 95% Rat Human -DTXSID8045355 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045355 Fup NA 0.166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045355 Vd NA 0.493 L/kg 1compartment NA NA Human Human -DTXSID8045355 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8045355 TK.Half.Life NA 19.23 hours 1compartment NA NA Human Human -DTXSID8045355 Css NA 4.81 mg/L 3compartmentss NA 50% Human Human -DTXSID8045355 Css NA 17.49 mg/L 3compartmentss NA 95% Human Human -DTXSID8045355 Css NA 3.166 mg/L PBTK NA 50% Human Human -DTXSID8045355 Css NA 10.78 mg/L PBTK NA 95% Human Human -DTXSID8045355 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045355 Fup NA 0.166 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045355 Vd NA 0.4912 L/kg 1compartment NA NA Rat Human -DTXSID8045355 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045355 TK.Half.Life NA 6.527 hours 1compartment NA NA Rat Human -DTXSID8045355 Css NA 1.362 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045355 Css NA 4.095 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045355 Css NA 0.8447 mg/L PBTK NA 50% Rat Human -DTXSID8045355 Css NA 2.331 mg/L PBTK NA 95% Rat Human -DTXSID8045357 Clint NA 10.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045357 Fup NA 0.1315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045357 Vd NA 3.779 L/kg 1compartment NA NA Human Human +DTXSID8045351 TK.Half.Life NA 0.6161 hours 1compartment NA NA Rat Human +DTXSID8045351 Css NA 0.04739 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045351 Css NA 0.1934 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045351 Css NA 0.02929 mg/L PBTK NA 50% Rat Human +DTXSID8045351 Css NA 0.1149 mg/L PBTK NA 95% Rat Human +DTXSID8045357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045357 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045357 Vd NA 3.755 L/kg 1compartment NA NA Human Human DTXSID8045357 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045357 TK.Half.Life NA 9.08 hours 1compartment NA NA Human Human -DTXSID8045357 Css NA 0.1947 mg/L 3compartmentss NA 50% Human Human -DTXSID8045357 Css NA 1.511 mg/L 3compartmentss NA 95% Human Human -DTXSID8045357 Css NA 0.1881 mg/L PBTK NA 50% Human Human -DTXSID8045357 Css NA 1.238 mg/L PBTK NA 95% Human Human -DTXSID8045357 Clint NA 10.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045357 Fup NA 0.1315 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045357 Vd NA 3.487 L/kg 1compartment NA NA Rat Human +DTXSID8045357 TK.Half.Life NA 4.593 hours 1compartment NA NA Human Human +DTXSID8045357 Css NA 0.05754 mg/L 3compartmentss NA 50% Human Human +DTXSID8045357 Css NA 0.4684 mg/L 3compartmentss NA 95% Human Human +DTXSID8045357 Css NA 0.06297 mg/L PBTK NA 50% Human Human +DTXSID8045357 Css NA 0.4307 mg/L PBTK NA 95% Human Human +DTXSID8045357 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045357 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045357 Vd NA 3.663 L/kg 1compartment NA NA Rat Human DTXSID8045357 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045357 TK.Half.Life NA 3.786 hours 1compartment NA NA Rat Human -DTXSID8045357 Css NA 0.1026 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045357 Css NA 0.6479 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045357 Css NA 0.09712 mg/L PBTK NA 50% Rat Human -DTXSID8045357 Css NA 0.5159 mg/L PBTK NA 95% Rat Human -DTXSID8045359 Clint NA 11.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045359 Fup NA 0.0649 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045359 Vd NA 3.363 L/kg 1compartment NA NA Human Human +DTXSID8045357 TK.Half.Life NA 2.335 hours 1compartment NA NA Rat Human +DTXSID8045357 Css NA 0.007036 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045357 Css NA 0.04563 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045357 Css NA 0.008004 mg/L PBTK NA 50% Rat Human +DTXSID8045357 Css NA 0.04249 mg/L PBTK NA 95% Rat Human +DTXSID8045359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045359 Fup 0.0607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045359 Vd NA 3.258 L/kg 1compartment NA NA Human Human DTXSID8045359 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045359 TK.Half.Life NA 7.673 hours 1compartment NA NA Human Human -DTXSID8045359 Css NA 0.1956 mg/L 3compartmentss NA 50% Human Human -DTXSID8045359 Css NA 1.489 mg/L 3compartmentss NA 95% Human Human -DTXSID8045359 Css NA 0.1697 mg/L PBTK NA 50% Human Human -DTXSID8045359 Css NA 1.134 mg/L PBTK NA 95% Human Human -DTXSID8045359 Clint NA 11.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045359 Fup NA 0.0649 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045359 Vd NA 3.02 L/kg 1compartment NA NA Rat Human +DTXSID8045359 TK.Half.Life NA 5.104 hours 1compartment NA NA Human Human +DTXSID8045359 Css NA 0.1146 mg/L 3compartmentss NA 50% Human Human +DTXSID8045359 Css NA 0.8979 mg/L 3compartmentss NA 95% Human Human +DTXSID8045359 Css NA 0.09752 mg/L PBTK NA 50% Human Human +DTXSID8045359 Css NA 0.674 mg/L PBTK NA 95% Human Human +DTXSID8045359 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045359 Fup 0.0607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045359 Vd NA 2.931 L/kg 1compartment NA NA Rat Human DTXSID8045359 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045359 TK.Half.Life NA 3.114 hours 1compartment NA NA Rat Human -DTXSID8045359 Css NA 0.1073 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045359 Css NA 0.6677 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045359 Css NA 0.09096 mg/L PBTK NA 50% Rat Human -DTXSID8045359 Css NA 0.5059 mg/L PBTK NA 95% Rat Human -DTXSID8045432 Clint NA 58.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045432 Fup NA 0.6949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045432 Vd NA 1.375 L/kg 1compartment NA NA Human Human +DTXSID8045359 TK.Half.Life NA 2.111 hours 1compartment NA NA Rat Human +DTXSID8045359 Css NA 0.01446 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045359 Css NA 0.1027 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045359 Css NA 0.01248 mg/L PBTK NA 50% Rat Human +DTXSID8045359 Css NA 0.07768 mg/L PBTK NA 95% Rat Human +DTXSID8045432 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045432 Fup 0.801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045432 Vd NA 0.605 L/kg 1compartment NA NA Human Human DTXSID8045432 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045432 TK.Half.Life NA 0.8648 hours 1compartment NA NA Human Human -DTXSID8045432 Css NA 0.01093 mg/L 3compartmentss NA 50% Human Human -DTXSID8045432 Css NA 0.1224 mg/L 3compartmentss NA 95% Human Human -DTXSID8045432 Css NA 0.009852 mg/L PBTK NA 50% Human Human -DTXSID8045432 Css NA 0.08764 mg/L PBTK NA 95% Human Human -DTXSID8045432 Clint NA 58.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045432 Fup NA 0.6949 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045432 Vd NA 1.404 L/kg 1compartment NA NA Rat Human +DTXSID8045432 TK.Half.Life NA 4.885 hours 1compartment NA NA Human Human +DTXSID8045432 Css NA 0.9946 mg/L 3compartmentss NA 50% Human Human +DTXSID8045432 Css NA 5.915 mg/L 3compartmentss NA 95% Human Human +DTXSID8045432 Css NA 0.7893 mg/L PBTK NA 50% Human Human +DTXSID8045432 Css NA 3.795 mg/L PBTK NA 95% Human Human +DTXSID8045432 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045432 Fup 0.801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045432 Vd NA 0.6492 L/kg 1compartment NA NA Rat Human DTXSID8045432 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045432 TK.Half.Life NA 0.4094 hours 1compartment NA NA Rat Human -DTXSID8045432 Css NA 0.005477 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045432 Css NA 0.0587 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045432 Css NA 0.004964 mg/L PBTK NA 50% Rat Human -DTXSID8045432 Css NA 0.04001 mg/L PBTK NA 95% Rat Human -DTXSID8045434 Clint NA 11.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045434 Fup NA 0.9712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045434 Vd NA 0.6531 L/kg 1compartment NA NA Human Human +DTXSID8045432 TK.Half.Life NA 1.787 hours 1compartment NA NA Rat Human +DTXSID8045432 Css NA 0.05947 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045432 Css NA 0.3397 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045432 Css NA 0.04712 mg/L PBTK NA 50% Rat Human +DTXSID8045432 Css NA 0.2077 mg/L PBTK NA 95% Rat Human +DTXSID8045434 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045434 Fup 0.61 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045434 Vd NA 0.5016 L/kg 1compartment NA NA Human Human DTXSID8045434 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045434 TK.Half.Life NA 0.564 hours 1compartment NA NA Human Human -DTXSID8045434 Css NA 0.04899 mg/L 3compartmentss NA 50% Human Human -DTXSID8045434 Css NA 0.4399 mg/L 3compartmentss NA 95% Human Human -DTXSID8045434 Css NA 0.03779 mg/L PBTK NA 50% Human Human -DTXSID8045434 Css NA 0.3053 mg/L PBTK NA 95% Human Human -DTXSID8045434 Clint NA 11.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045434 Fup NA 0.9712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045434 Vd NA 0.6885 L/kg 1compartment NA NA Rat Human +DTXSID8045434 TK.Half.Life NA 5.32 hours 1compartment NA NA Human Human +DTXSID8045434 Css NA 1.25 mg/L 3compartmentss NA 50% Human Human +DTXSID8045434 Css NA 8.339 mg/L 3compartmentss NA 95% Human Human +DTXSID8045434 Css NA 0.9355 mg/L PBTK NA 50% Human Human +DTXSID8045434 Css NA 5.098 mg/L PBTK NA 95% Human Human +DTXSID8045434 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045434 Fup 0.61 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045434 Vd NA 0.5273 L/kg 1compartment NA NA Rat Human DTXSID8045434 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045434 TK.Half.Life NA 0.2937 hours 1compartment NA NA Rat Human -DTXSID8045434 Css NA 0.02369 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045434 Css NA 0.1801 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045434 Css NA 0.0183 mg/L PBTK NA 50% Rat Human -DTXSID8045434 Css NA 0.1158 mg/L PBTK NA 95% Rat Human -DTXSID8045438 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045438 Fup NA 0.3103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045438 Vd NA 2.897 L/kg 1compartment NA NA Human Human +DTXSID8045434 TK.Half.Life NA 1.906 hours 1compartment NA NA Rat Human +DTXSID8045434 Css NA 0.0774 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045434 Css NA 0.4796 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045434 Css NA 0.05716 mg/L PBTK NA 50% Rat Human +DTXSID8045434 Css NA 0.2855 mg/L PBTK NA 95% Rat Human +DTXSID8045438 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045438 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045438 Vd NA 2.274 L/kg 1compartment NA NA Human Human DTXSID8045438 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045438 TK.Half.Life NA 7.853 hours 1compartment NA NA Human Human -DTXSID8045438 Css NA 0.1796 mg/L 3compartmentss NA 50% Human Human -DTXSID8045438 Css NA 1.272 mg/L 3compartmentss NA 95% Human Human -DTXSID8045438 Css NA 0.2035 mg/L PBTK NA 50% Human Human -DTXSID8045438 Css NA 1.096 mg/L PBTK NA 95% Human Human -DTXSID8045438 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045438 Fup NA 0.3103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045438 Vd NA 2.902 L/kg 1compartment NA NA Rat Human +DTXSID8045438 TK.Half.Life NA 4.693 hours 1compartment NA NA Human Human +DTXSID8045438 Css NA 0.1146 mg/L 3compartmentss NA 50% Human Human +DTXSID8045438 Css NA 0.9126 mg/L 3compartmentss NA 95% Human Human +DTXSID8045438 Css NA 0.1173 mg/L PBTK NA 50% Human Human +DTXSID8045438 Css NA 0.7382 mg/L PBTK NA 95% Human Human +DTXSID8045438 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045438 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045438 Vd NA 2.266 L/kg 1compartment NA NA Rat Human DTXSID8045438 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045438 TK.Half.Life NA 4.624 hours 1compartment NA NA Rat Human -DTXSID8045438 Css NA 0.08695 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045438 Css NA 0.4803 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045438 Css NA 0.09765 mg/L PBTK NA 50% Rat Human -DTXSID8045438 Css NA 0.3814 mg/L PBTK NA 95% Rat Human +DTXSID8045438 TK.Half.Life NA 2.741 hours 1compartment NA NA Rat Human +DTXSID8045438 Css NA 0.004948 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045438 Css NA 0.04227 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045438 Css NA 0.005234 mg/L PBTK NA 50% Rat Human +DTXSID8045438 Css NA 0.03428 mg/L PBTK NA 95% Rat Human DTXSID8045480 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8045480 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045480 Vd NA 1.025 L/kg 1compartment NA NA Human Human +DTXSID8045480 Vd NA 1.181 L/kg 1compartment NA NA Human Human DTXSID8045480 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045480 TK.Half.Life NA 6.633 hours 1compartment NA NA Human Human -DTXSID8045480 Css NA 0.7968 mg/L 3compartmentss NA 50% Human Human -DTXSID8045480 Css NA 5.459 mg/L 3compartmentss NA 95% Human Human -DTXSID8045480 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID8045480 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID8045480 TK.Half.Life NA 7.643 hours 1compartment NA NA Human Human +DTXSID8045480 Css NA 0.4277 mg/L 3compartmentss NA 50% Human Human +DTXSID8045480 Css NA 2.939 mg/L 3compartmentss NA 95% Human Human +DTXSID8045480 Css NA 0.3837 mg/L PBTK NA 50% Human Human +DTXSID8045480 Css NA 2 mg/L PBTK NA 95% Human Human DTXSID8045480 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8045480 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045480 Vd NA 1.069 L/kg 1compartment NA NA Rat Human +DTXSID8045480 Vd NA 1.214 L/kg 1compartment NA NA Rat Human DTXSID8045480 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045480 TK.Half.Life NA 2.357 hours 1compartment NA NA Rat Human -DTXSID8045480 Css NA 0.1992 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045480 Css NA 1.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045480 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID8045480 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID8045484 Clint NA 11.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045484 Fup NA 0.8883 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045484 Vd NA 0.7948 L/kg 1compartment NA NA Human Human +DTXSID8045480 TK.Half.Life NA 2.677 hours 1compartment NA NA Rat Human +DTXSID8045480 Css NA 0.002114 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045480 Css NA 0.01558 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045480 Css NA 0.00187 mg/L PBTK NA 50% Rat Human +DTXSID8045480 Css NA 0.01021 mg/L PBTK NA 95% Rat Human +DTXSID8045484 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045484 Fup 0.682 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045484 Vd NA 0.5959 L/kg 1compartment NA NA Human Human DTXSID8045484 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045484 TK.Half.Life NA 0.7157 hours 1compartment NA NA Human Human -DTXSID8045484 Css NA 0.05142 mg/L 3compartmentss NA 50% Human Human -DTXSID8045484 Css NA 0.4847 mg/L 3compartmentss NA 95% Human Human -DTXSID8045484 Css NA 0.04195 mg/L PBTK NA 50% Human Human -DTXSID8045484 Css NA 0.3365 mg/L PBTK NA 95% Human Human -DTXSID8045484 Clint NA 11.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045484 Fup NA 0.8883 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045484 Vd NA 0.8154 L/kg 1compartment NA NA Rat Human +DTXSID8045484 TK.Half.Life NA 5.654 hours 1compartment NA NA Human Human +DTXSID8045484 Css NA 0.99 mg/L 3compartmentss NA 50% Human Human +DTXSID8045484 Css NA 6.133 mg/L 3compartmentss NA 95% Human Human +DTXSID8045484 Css NA 0.774 mg/L PBTK NA 50% Human Human +DTXSID8045484 Css NA 3.927 mg/L PBTK NA 95% Human Human +DTXSID8045484 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045484 Fup 0.682 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045484 Vd NA 0.6245 L/kg 1compartment NA NA Rat Human DTXSID8045484 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045484 TK.Half.Life NA 0.3701 hours 1compartment NA NA Rat Human -DTXSID8045484 Css NA 0.02512 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045484 Css NA 0.1897 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045484 Css NA 0.02035 mg/L PBTK NA 50% Rat Human -DTXSID8045484 Css NA 0.1227 mg/L PBTK NA 95% Rat Human +DTXSID8045484 TK.Half.Life NA 2.019 hours 1compartment NA NA Rat Human +DTXSID8045484 Css NA 0.02586 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045484 Css NA 0.1898 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045484 Css NA 0.01962 mg/L PBTK NA 50% Rat Human +DTXSID8045484 Css NA 0.119 mg/L PBTK NA 95% Rat Human DTXSID8045486 Clint 1.869 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID8045486 Fup 0.009 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID8045486 Vd NA 0.1811 L/kg 1compartment NA NA Human Human +DTXSID8045486 Vd NA 0.1815 L/kg 1compartment NA NA Human Human DTXSID8045486 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID8045486 TK.Half.Life NA 31.62 hours 1compartment NA NA Human Human -DTXSID8045486 Css NA 26.23 mg/L 3compartmentss NA 50% Human Human -DTXSID8045486 Css NA 214.3 mg/L 3compartmentss NA 95% Human Human -DTXSID8045486 Css NA 17.48 mg/L PBTK NA 50% Human Human -DTXSID8045486 Css NA 129.2 mg/L PBTK NA 95% Human Human +DTXSID8045486 TK.Half.Life NA 31.69 hours 1compartment NA NA Human Human +DTXSID8045486 Css NA 27.26 mg/L 3compartmentss NA 50% Human Human +DTXSID8045486 Css NA 194.8 mg/L 3compartmentss NA 95% Human Human +DTXSID8045486 Css NA 18.26 mg/L PBTK NA 50% Human Human +DTXSID8045486 Css NA 130.5 mg/L PBTK NA 95% Human Human DTXSID8045486 Clint 1.869 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID8045486 Fup 0.009 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human -DTXSID8045486 Vd NA 0.1899 L/kg 1compartment NA NA Rat Human +DTXSID8045486 Vd NA 0.1904 L/kg 1compartment NA NA Rat Human DTXSID8045486 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8045486 TK.Half.Life NA 9.801 hours 1compartment NA NA Rat Human -DTXSID8045486 Css NA 6.749 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045486 Css NA 44.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045486 Css NA 4.252 mg/L PBTK NA 50% Rat Human -DTXSID8045486 Css NA 24.8 mg/L PBTK NA 95% Rat Human -DTXSID8045488 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045488 Fup NA 0.1192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045488 Vd NA 0.238 L/kg 1compartment NA NA Human Human -DTXSID8045488 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8045488 TK.Half.Life NA 12.92 hours 1compartment NA NA Human Human -DTXSID8045488 Css NA 8.442 mg/L 3compartmentss NA 50% Human Human -DTXSID8045488 Css NA 38.32 mg/L 3compartmentss NA 95% Human Human -DTXSID8045488 Css NA 5.134 mg/L PBTK NA 50% Human Human -DTXSID8045488 Css NA 22.36 mg/L PBTK NA 95% Human Human -DTXSID8045488 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045488 Fup NA 0.1192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045488 Vd NA 0.2403 L/kg 1compartment NA NA Rat Human +DTXSID8045486 TK.Half.Life NA 9.826 hours 1compartment NA NA Rat Human +DTXSID8045486 Css NA 1.426 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045486 Css NA 8.538 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045486 Css NA 0.9893 mg/L PBTK NA 50% Rat Human +DTXSID8045486 Css NA 5.923 mg/L PBTK NA 95% Rat Human +DTXSID8045488 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045488 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045488 Vd NA 0.2543 L/kg 1compartment NA NA Human Human +DTXSID8045488 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045488 TK.Half.Life NA 0.9441 hours 1compartment NA NA Human Human +DTXSID8045488 Css NA 0.208 mg/L 3compartmentss NA 50% Human Human +DTXSID8045488 Css NA 1.332 mg/L 3compartmentss NA 95% Human Human +DTXSID8045488 Css NA 0.129 mg/L PBTK NA 50% Human Human +DTXSID8045488 Css NA 0.8093 mg/L PBTK NA 95% Human Human +DTXSID8045488 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045488 Fup 0.178 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045488 Vd NA 0.2602 L/kg 1compartment NA NA Rat Human DTXSID8045488 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045488 TK.Half.Life NA 4.446 hours 1compartment NA NA Rat Human -DTXSID8045488 Css NA 2.383 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045488 Css NA 8.966 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045488 Css NA 1.36 mg/L PBTK NA 50% Rat Human -DTXSID8045488 Css NA 4.918 mg/L PBTK NA 95% Rat Human -DTXSID8045511 Clint NA 3.232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8045488 TK.Half.Life NA 0.5705 hours 1compartment NA NA Rat Human +DTXSID8045488 Css NA 0.002031 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045488 Css NA 0.01124 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045488 Css NA 0.001205 mg/L PBTK NA 50% Rat Human +DTXSID8045488 Css NA 0.006467 mg/L PBTK NA 95% Rat Human +DTXSID8045511 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8045511 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8045511 Vd NA 2.959 L/kg 1compartment NA NA Human Human -DTXSID8045511 Days.Css NA 27 Days PBTK NA NA Human Human -DTXSID8045511 TK.Half.Life NA 147.4 hours 1compartment NA NA Human Human -DTXSID8045511 Css NA 6.292 mg/L 3compartmentss NA 50% Human Human -DTXSID8045511 Css NA 30.8 mg/L 3compartmentss NA 95% Human Human -DTXSID8045511 Css NA 4.421 mg/L PBTK NA 50% Human Human -DTXSID8045511 Css NA 20.7 mg/L PBTK NA 95% Human Human -DTXSID8045511 Clint NA 3.232 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8045511 Vd NA 2.658 L/kg 1compartment NA NA Human Human +DTXSID8045511 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045511 TK.Half.Life NA 13.68 hours 1compartment NA NA Human Human +DTXSID8045511 Css NA 0.5802 mg/L 3compartmentss NA 50% Human Human +DTXSID8045511 Css NA 3.778 mg/L 3compartmentss NA 95% Human Human +DTXSID8045511 Css NA 0.4019 mg/L PBTK NA 50% Human Human +DTXSID8045511 Css NA 2.512 mg/L PBTK NA 95% Human Human +DTXSID8045511 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8045511 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8045511 Vd NA 2.223 L/kg 1compartment NA NA Rat Human -DTXSID8045511 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID8045511 TK.Half.Life NA 22.82 hours 1compartment NA NA Rat Human -DTXSID8045511 Css NA 3.266 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045511 Css NA 11.54 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045511 Css NA 2.184 mg/L PBTK NA 50% Rat Human -DTXSID8045511 Css NA 7.478 mg/L PBTK NA 95% Rat Human -DTXSID8045513 Clint NA 16.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045513 Fup NA 0.0578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045513 Vd NA 2.372 L/kg 1compartment NA NA Human Human +DTXSID8045511 Vd NA 2.001 L/kg 1compartment NA NA Rat Human +DTXSID8045511 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8045511 TK.Half.Life NA 3.228 hours 1compartment NA NA Rat Human +DTXSID8045511 Css NA 0.07333 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045511 Css NA 0.3978 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045511 Css NA 0.05011 mg/L PBTK NA 50% Rat Human +DTXSID8045511 Css NA 0.2662 mg/L PBTK NA 95% Rat Human +DTXSID8045513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045513 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045513 Vd NA 2.064 L/kg 1compartment NA NA Human Human DTXSID8045513 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8045513 TK.Half.Life NA 17.78 hours 1compartment NA NA Human Human -DTXSID8045513 Css NA 0.976 mg/L 3compartmentss NA 50% Human Human -DTXSID8045513 Css NA 6.594 mg/L 3compartmentss NA 95% Human Human -DTXSID8045513 Css NA 0.6562 mg/L PBTK NA 50% Human Human -DTXSID8045513 Css NA 4.297 mg/L PBTK NA 95% Human Human -DTXSID8045513 Clint NA 16.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045513 Fup NA 0.0578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045513 Vd NA 1.78 L/kg 1compartment NA NA Rat Human +DTXSID8045513 TK.Half.Life NA 19.04 hours 1compartment NA NA Human Human +DTXSID8045513 Css NA 1.344 mg/L 3compartmentss NA 50% Human Human +DTXSID8045513 Css NA 10.7 mg/L 3compartmentss NA 95% Human Human +DTXSID8045513 Css NA 0.8725 mg/L PBTK NA 50% Human Human +DTXSID8045513 Css NA 6.694 mg/L PBTK NA 95% Human Human +DTXSID8045513 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045513 Fup 0.024 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045513 Vd NA 1.536 L/kg 1compartment NA NA Rat Human DTXSID8045513 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045513 TK.Half.Life NA 4.834 hours 1compartment NA NA Rat Human -DTXSID8045513 Css NA 0.545 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045513 Css NA 2.734 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045513 Css NA 0.3474 mg/L PBTK NA 50% Rat Human -DTXSID8045513 Css NA 1.661 mg/L PBTK NA 95% Rat Human -DTXSID8045515 Clint NA 2192 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045515 Fup NA 0.4788 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045515 Vd NA 2.477 L/kg 1compartment NA NA Human Human +DTXSID8045513 TK.Half.Life NA 5.97 hours 1compartment NA NA Rat Human +DTXSID8045513 Css NA 0.1718 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045513 Css NA 1.153 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045513 Css NA 0.1088 mg/L PBTK NA 50% Rat Human +DTXSID8045513 Css NA 0.6906 mg/L PBTK NA 95% Rat Human +DTXSID8045515 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045515 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045515 Vd NA 1.035 L/kg 1compartment NA NA Human Human DTXSID8045515 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045515 TK.Half.Life NA 1.426 hours 1compartment NA NA Human Human -DTXSID8045515 Css NA 0.0004683 mg/L 3compartmentss NA 50% Human Human -DTXSID8045515 Css NA 0.004229 mg/L 3compartmentss NA 95% Human Human -DTXSID8045515 Css NA 0.0004351 mg/L PBTK NA 50% Human Human -DTXSID8045515 Css NA 0.003357 mg/L PBTK NA 95% Human Human -DTXSID8045515 Clint NA 2192 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045515 Fup NA 0.4788 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045515 Vd NA 2.222 L/kg 1compartment NA NA Rat Human +DTXSID8045515 TK.Half.Life NA 2.275 hours 1compartment NA NA Human Human +DTXSID8045515 Css NA 0.1784 mg/L 3compartmentss NA 50% Human Human +DTXSID8045515 Css NA 1.168 mg/L 3compartmentss NA 95% Human Human +DTXSID8045515 Css NA 0.1353 mg/L PBTK NA 50% Human Human +DTXSID8045515 Css NA 0.7924 mg/L PBTK NA 95% Human Human +DTXSID8045515 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045515 Fup 0.381 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045515 Vd NA 0.8741 L/kg 1compartment NA NA Rat Human DTXSID8045515 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045515 TK.Half.Life NA 0.5519 hours 1compartment NA NA Rat Human -DTXSID8045515 Css NA 0.0002528 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045515 Css NA 0.001839 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045515 Css NA 0.0002294 mg/L PBTK NA 50% Rat Human -DTXSID8045515 Css NA 0.001423 mg/L PBTK NA 95% Rat Human -DTXSID8045519 Clint NA 4.061 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045519 Fup NA 0.4545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045519 Vd NA 1.921 L/kg 1compartment NA NA Human Human +DTXSID8045515 TK.Half.Life NA 1.024 hours 1compartment NA NA Rat Human +DTXSID8045515 Css NA 0.02077 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045515 Css NA 0.1039 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045515 Css NA 0.01573 mg/L PBTK NA 50% Rat Human +DTXSID8045515 Css NA 0.06803 mg/L PBTK NA 95% Rat Human +DTXSID8045519 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045519 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045519 Vd NA 1.949 L/kg 1compartment NA NA Human Human DTXSID8045519 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045519 TK.Half.Life NA 5.208 hours 1compartment NA NA Human Human -DTXSID8045519 Css NA 0.2303 mg/L 3compartmentss NA 50% Human Human -DTXSID8045519 Css NA 1.459 mg/L 3compartmentss NA 95% Human Human -DTXSID8045519 Css NA 0.1975 mg/L PBTK NA 50% Human Human -DTXSID8045519 Css NA 1.054 mg/L PBTK NA 95% Human Human -DTXSID8045519 Clint NA 4.061 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045519 Fup NA 0.4545 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045519 Vd NA 1.672 L/kg 1compartment NA NA Rat Human +DTXSID8045519 TK.Half.Life NA 3.508 hours 1compartment NA NA Human Human +DTXSID8045519 Css NA 0.1269 mg/L 3compartmentss NA 50% Human Human +DTXSID8045519 Css NA 0.9772 mg/L 3compartmentss NA 95% Human Human +DTXSID8045519 Css NA 0.1139 mg/L PBTK NA 50% Human Human +DTXSID8045519 Css NA 0.7082 mg/L PBTK NA 95% Human Human +DTXSID8045519 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045519 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045519 Vd NA 1.719 L/kg 1compartment NA NA Rat Human DTXSID8045519 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045519 TK.Half.Life NA 2.203 hours 1compartment NA NA Rat Human -DTXSID8045519 Css NA 0.1121 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045519 Css NA 0.5323 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045519 Css NA 0.09444 mg/L PBTK NA 50% Rat Human -DTXSID8045519 Css NA 0.3569 mg/L PBTK NA 95% Rat Human -DTXSID8045561 Clint NA 3.459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045561 Fup NA 0.2871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045561 Vd NA 0.35 L/kg 1compartment NA NA Human Human +DTXSID8045519 TK.Half.Life NA 1.529 hours 1compartment NA NA Rat Human +DTXSID8045519 Css NA 0.01473 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045519 Css NA 0.09339 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045519 Css NA 0.01333 mg/L PBTK NA 50% Rat Human +DTXSID8045519 Css NA 0.06418 mg/L PBTK NA 95% Rat Human +DTXSID8045561 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045561 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045561 Vd NA 0.4194 L/kg 1compartment NA NA Human Human DTXSID8045561 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045561 TK.Half.Life NA 1.363 hours 1compartment NA NA Human Human -DTXSID8045561 Css NA 0.4198 mg/L 3compartmentss NA 50% Human Human -DTXSID8045561 Css NA 2.283 mg/L 3compartmentss NA 95% Human Human -DTXSID8045561 Css NA 0.2812 mg/L PBTK NA 50% Human Human -DTXSID8045561 Css NA 1.43 mg/L PBTK NA 95% Human Human -DTXSID8045561 Clint NA 3.459 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045561 Fup NA 0.2871 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045561 Vd NA 0.3548 L/kg 1compartment NA NA Rat Human +DTXSID8045561 TK.Half.Life NA 6.49 hours 1compartment NA NA Human Human +DTXSID8045561 Css NA 0.964 mg/L 3compartmentss NA 50% Human Human +DTXSID8045561 Css NA 4.492 mg/L 3compartmentss NA 95% Human Human +DTXSID8045561 Css NA 0.6864 mg/L PBTK NA 50% Human Human +DTXSID8045561 Css NA 2.824 mg/L PBTK NA 95% Human Human +DTXSID8045561 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045561 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045561 Vd NA 0.4265 L/kg 1compartment NA NA Rat Human DTXSID8045561 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045561 TK.Half.Life NA 0.7802 hours 1compartment NA NA Rat Human -DTXSID8045561 Css NA 0.2074 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045561 Css NA 0.803 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045561 Css NA 0.132 mg/L PBTK NA 50% Rat Human -DTXSID8045561 Css NA 0.4662 mg/L PBTK NA 95% Rat Human -DTXSID8045563 Clint NA 33.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045563 Fup NA 0.0634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045563 Vd NA 2.463 L/kg 1compartment NA NA Human Human +DTXSID8045561 TK.Half.Life NA 2.25 hours 1compartment NA NA Rat Human +DTXSID8045561 Css NA 0.005224 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045561 Css NA 0.02443 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045561 Css NA 0.003562 mg/L PBTK NA 50% Rat Human +DTXSID8045561 Css NA 0.01459 mg/L PBTK NA 95% Rat Human +DTXSID8045563 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045563 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045563 Vd NA 1.108 L/kg 1compartment NA NA Human Human DTXSID8045563 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045563 TK.Half.Life NA 3.508 hours 1compartment NA NA Human Human -DTXSID8045563 Css NA 0.1037 mg/L 3compartmentss NA 50% Human Human -DTXSID8045563 Css NA 0.9917 mg/L 3compartmentss NA 95% Human Human -DTXSID8045563 Css NA 0.08666 mg/L PBTK NA 50% Human Human -DTXSID8045563 Css NA 0.6909 mg/L PBTK NA 95% Human Human -DTXSID8045563 Clint NA 33.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045563 Fup NA 0.0634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045563 Vd NA 2.381 L/kg 1compartment NA NA Rat Human +DTXSID8045563 TK.Half.Life NA 2.383 hours 1compartment NA NA Human Human +DTXSID8045563 Css NA 0.201 mg/L 3compartmentss NA 50% Human Human +DTXSID8045563 Css NA 1.776 mg/L 3compartmentss NA 95% Human Human +DTXSID8045563 Css NA 0.1417 mg/L PBTK NA 50% Human Human +DTXSID8045563 Css NA 1.114 mg/L PBTK NA 95% Human Human +DTXSID8045563 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045563 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045563 Vd NA 1.097 L/kg 1compartment NA NA Rat Human DTXSID8045563 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045563 TK.Half.Life NA 1.87 hours 1compartment NA NA Rat Human -DTXSID8045563 Css NA 0.05874 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045563 Css NA 0.4214 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045563 Css NA 0.04723 mg/L PBTK NA 50% Rat Human -DTXSID8045563 Css NA 0.2909 mg/L PBTK NA 95% Rat Human -DTXSID8045565 Clint NA 30.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045565 Fup NA 0.0396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045565 Vd NA 2.74 L/kg 1compartment NA NA Human Human +DTXSID8045563 TK.Half.Life NA 1.394 hours 1compartment NA NA Rat Human +DTXSID8045563 Css NA 0.02613 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045563 Css NA 0.1702 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045563 Css NA 0.01806 mg/L PBTK NA 50% Rat Human +DTXSID8045563 Css NA 0.1061 mg/L PBTK NA 95% Rat Human +DTXSID8045565 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045565 Fup 0.0546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045565 Vd NA 3.396 L/kg 1compartment NA NA Human Human DTXSID8045565 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045565 TK.Half.Life NA 2.712 hours 1compartment NA NA Human Human -DTXSID8045565 Css NA 0.04916 mg/L 3compartmentss NA 50% Human Human -DTXSID8045565 Css NA 0.5412 mg/L 3compartmentss NA 95% Human Human -DTXSID8045565 Css NA 0.04214 mg/L PBTK NA 50% Human Human -DTXSID8045565 Css NA 0.3822 mg/L PBTK NA 95% Human Human -DTXSID8045565 Clint NA 30.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045565 Fup NA 0.0396 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045565 Vd NA 2.547 L/kg 1compartment NA NA Rat Human +DTXSID8045565 TK.Half.Life NA 6.123 hours 1compartment NA NA Human Human +DTXSID8045565 Css NA 0.1393 mg/L 3compartmentss NA 50% Human Human +DTXSID8045565 Css NA 1.246 mg/L 3compartmentss NA 95% Human Human +DTXSID8045565 Css NA 0.1296 mg/L PBTK NA 50% Human Human +DTXSID8045565 Css NA 0.9618 mg/L PBTK NA 95% Human Human +DTXSID8045565 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045565 Fup 0.0546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045565 Vd NA 3.14 L/kg 1compartment NA NA Rat Human DTXSID8045565 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045565 TK.Half.Life NA 1.243 hours 1compartment NA NA Rat Human -DTXSID8045565 Css NA 0.02793 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045565 Css NA 0.2568 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045565 Css NA 0.02271 mg/L PBTK NA 50% Rat Human -DTXSID8045565 Css NA 0.1724 mg/L PBTK NA 95% Rat Human -DTXSID8045567 Clint NA 77.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045567 Fup NA 0.0022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045567 Vd NA 0.1973 L/kg 1compartment NA NA Human Human +DTXSID8045565 TK.Half.Life NA 2.786 hours 1compartment NA NA Rat Human +DTXSID8045565 Css NA 0.0176 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045565 Css NA 0.1337 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045565 Css NA 0.0166 mg/L PBTK NA 50% Rat Human +DTXSID8045565 Css NA 0.1051 mg/L PBTK NA 95% Rat Human +DTXSID8045567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045567 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045567 Vd NA 0.2399 L/kg 1compartment NA NA Human Human DTXSID8045567 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045567 TK.Half.Life NA 4.519 hours 1compartment NA NA Human Human -DTXSID8045567 Css NA 4.158 mg/L 3compartmentss NA 50% Human Human -DTXSID8045567 Css NA 39.82 mg/L 3compartmentss NA 95% Human Human -DTXSID8045567 Css NA 2.436 mg/L PBTK NA 50% Human Human -DTXSID8045567 Css NA 23.19 mg/L PBTK NA 95% Human Human -DTXSID8045567 Clint NA 77.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045567 Fup NA 0.0022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045567 Vd NA 0.188 L/kg 1compartment NA NA Rat Human +DTXSID8045567 TK.Half.Life NA 3.265 hours 1compartment NA NA Human Human +DTXSID8045567 Css NA 2.366 mg/L 3compartmentss NA 50% Human Human +DTXSID8045567 Css NA 24.36 mg/L 3compartmentss NA 95% Human Human +DTXSID8045567 Css NA 1.406 mg/L PBTK NA 50% Human Human +DTXSID8045567 Css NA 14.08 mg/L PBTK NA 95% Human Human +DTXSID8045567 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045567 Fup 0.0137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045567 Vd NA 0.2321 L/kg 1compartment NA NA Rat Human DTXSID8045567 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045567 TK.Half.Life NA 2.951 hours 1compartment NA NA Rat Human -DTXSID8045567 Css NA 2.42 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045567 Css NA 19.25 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045567 Css NA 1.318 mg/L PBTK NA 50% Rat Human -DTXSID8045567 Css NA 10.42 mg/L PBTK NA 95% Rat Human -DTXSID8045569 Clint NA 10.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045569 Fup NA 0.1844 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045569 Vd NA 4.246 L/kg 1compartment NA NA Human Human +DTXSID8045567 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human +DTXSID8045567 Css NA 0.31 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045567 Css NA 2.437 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045567 Css NA 0.1778 mg/L PBTK NA 50% Rat Human +DTXSID8045567 Css NA 1.376 mg/L PBTK NA 95% Rat Human +DTXSID8045569 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045569 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045569 Vd NA 5.068 L/kg 1compartment NA NA Human Human DTXSID8045569 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045569 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human -DTXSID8045569 Css NA 0.07427 mg/L 3compartmentss NA 50% Human Human -DTXSID8045569 Css NA 0.5826 mg/L 3compartmentss NA 95% Human Human -DTXSID8045569 Css NA 0.0936 mg/L PBTK NA 50% Human Human -DTXSID8045569 Css NA 0.5871 mg/L PBTK NA 95% Human Human -DTXSID8045569 Clint NA 10.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045569 Fup NA 0.1844 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045569 Vd NA 4.248 L/kg 1compartment NA NA Rat Human +DTXSID8045569 TK.Half.Life NA 3.751 hours 1compartment NA NA Human Human +DTXSID8045569 Css NA 0.02256 mg/L 3compartmentss NA 50% Human Human +DTXSID8045569 Css NA 0.209 mg/L 3compartmentss NA 95% Human Human +DTXSID8045569 Css NA 0.03328 mg/L PBTK NA 50% Human Human +DTXSID8045569 Css NA 0.2332 mg/L PBTK NA 95% Human Human +DTXSID8045569 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045569 Fup 0.27 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045569 Vd NA 5.113 L/kg 1compartment NA NA Rat Human DTXSID8045569 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045569 TK.Half.Life NA 3.43 hours 1compartment NA NA Rat Human -DTXSID8045569 Css NA 0.03737 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045569 Css NA 0.2459 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045569 Css NA 0.04864 mg/L PBTK NA 50% Rat Human -DTXSID8045569 Css NA 0.2377 mg/L PBTK NA 95% Rat Human -DTXSID8045640 Clint NA 15.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045640 Fup NA 0.2252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045640 Vd NA 4.563 L/kg 1compartment NA NA Human Human +DTXSID8045569 TK.Half.Life NA 2.036 hours 1compartment NA NA Rat Human +DTXSID8045569 Css NA 0.002676 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045569 Css NA 0.02005 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045569 Css NA 0.004248 mg/L PBTK NA 50% Rat Human +DTXSID8045569 Css NA 0.02278 mg/L PBTK NA 95% Rat Human +DTXSID8045640 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045640 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045640 Vd NA 4.237 L/kg 1compartment NA NA Human Human DTXSID8045640 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045640 TK.Half.Life NA 5.594 hours 1compartment NA NA Human Human -DTXSID8045640 Css NA 0.05889 mg/L 3compartmentss NA 50% Human Human -DTXSID8045640 Css NA 0.4552 mg/L 3compartmentss NA 95% Human Human -DTXSID8045640 Css NA 0.07264 mg/L PBTK NA 50% Human Human -DTXSID8045640 Css NA 0.464 mg/L PBTK NA 95% Human Human -DTXSID8045640 Clint NA 15.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045640 Fup NA 0.2252 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045640 Vd NA 4.45 L/kg 1compartment NA NA Rat Human +DTXSID8045640 TK.Half.Life NA 4.725 hours 1compartment NA NA Human Human +DTXSID8045640 Css NA 0.04825 mg/L 3compartmentss NA 50% Human Human +DTXSID8045640 Css NA 0.3873 mg/L 3compartmentss NA 95% Human Human +DTXSID8045640 Css NA 0.0567 mg/L PBTK NA 50% Human Human +DTXSID8045640 Css NA 0.3747 mg/L PBTK NA 95% Human Human +DTXSID8045640 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045640 Fup 0.193 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045640 Vd NA 4.116 L/kg 1compartment NA NA Rat Human DTXSID8045640 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045640 TK.Half.Life NA 2.698 hours 1compartment NA NA Rat Human -DTXSID8045640 Css NA 0.03062 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045640 Css NA 0.1849 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045640 Css NA 0.0379 mg/L PBTK NA 50% Rat Human -DTXSID8045640 Css NA 0.1802 mg/L PBTK NA 95% Rat Human -DTXSID8045642 Clint NA 10.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045642 Fup NA 0.1624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045642 Vd NA 2.323 L/kg 1compartment NA NA Human Human +DTXSID8045640 TK.Half.Life NA 2.286 hours 1compartment NA NA Rat Human +DTXSID8045640 Css NA 0.005923 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045640 Css NA 0.03639 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045640 Css NA 0.007161 mg/L PBTK NA 50% Rat Human +DTXSID8045640 Css NA 0.036 mg/L PBTK NA 95% Rat Human +DTXSID8045642 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045642 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045642 Vd NA 2.059 L/kg 1compartment NA NA Human Human DTXSID8045642 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045642 TK.Half.Life NA 11.4 hours 1compartment NA NA Human Human -DTXSID8045642 Css NA 0.5394 mg/L 3compartmentss NA 50% Human Human -DTXSID8045642 Css NA 3.204 mg/L 3compartmentss NA 95% Human Human -DTXSID8045642 Css NA 0.3834 mg/L PBTK NA 50% Human Human -DTXSID8045642 Css NA 2.156 mg/L PBTK NA 95% Human Human -DTXSID8045642 Clint NA 10.15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045642 Fup NA 0.1624 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045642 Vd NA 1.768 L/kg 1compartment NA NA Rat Human +DTXSID8045642 TK.Half.Life NA 6.49 hours 1compartment NA NA Human Human +DTXSID8045642 Css NA 0.335 mg/L 3compartmentss NA 50% Human Human +DTXSID8045642 Css NA 2.41 mg/L 3compartmentss NA 95% Human Human +DTXSID8045642 Css NA 0.227 mg/L PBTK NA 50% Human Human +DTXSID8045642 Css NA 1.549 mg/L PBTK NA 95% Human Human +DTXSID8045642 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045642 Fup 0.111 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045642 Vd NA 1.561 L/kg 1compartment NA NA Rat Human DTXSID8045642 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045642 TK.Half.Life NA 3.265 hours 1compartment NA NA Rat Human -DTXSID8045642 Css NA 0.2898 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045642 Css NA 1.306 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045642 Css NA 0.1962 mg/L PBTK NA 50% Rat Human -DTXSID8045642 Css NA 0.8362 mg/L PBTK NA 95% Rat Human -DTXSID8045646 Clint NA 0.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045646 Fup NA 0.0924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045646 Vd NA 1.115 L/kg 1compartment NA NA Human Human -DTXSID8045646 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID8045646 TK.Half.Life NA 33.78 hours 1compartment NA NA Human Human -DTXSID8045646 Css NA 4.492 mg/L 3compartmentss NA 50% Human Human -DTXSID8045646 Css NA 22.41 mg/L 3compartmentss NA 95% Human Human -DTXSID8045646 Css NA 2.926 mg/L PBTK NA 50% Human Human -DTXSID8045646 Css NA 13.54 mg/L PBTK NA 95% Human Human -DTXSID8045646 Clint NA 0.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045646 Fup NA 0.0924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045646 Vd NA 0.8583 L/kg 1compartment NA NA Rat Human -DTXSID8045646 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8045646 TK.Half.Life NA 11.5 hours 1compartment NA NA Rat Human -DTXSID8045646 Css NA 1.884 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045646 Css NA 7.527 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045646 Css NA 1.154 mg/L PBTK NA 50% Rat Human -DTXSID8045646 Css NA 4.22 mg/L PBTK NA 95% Rat Human -DTXSID8045648 Clint NA 1.733 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045648 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045648 Vd NA 0.7296 L/kg 1compartment NA NA Human Human +DTXSID8045642 TK.Half.Life NA 2.115 hours 1compartment NA NA Rat Human +DTXSID8045642 Css NA 0.04242 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045642 Css NA 0.2464 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045642 Css NA 0.02856 mg/L PBTK NA 50% Rat Human +DTXSID8045642 Css NA 0.1574 mg/L PBTK NA 95% Rat Human +DTXSID8045646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045646 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045646 Vd NA 1.137 L/kg 1compartment NA NA Human Human +DTXSID8045646 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045646 TK.Half.Life NA 2.524 hours 1compartment NA NA Human Human +DTXSID8045646 Css NA 0.2067 mg/L 3compartmentss NA 50% Human Human +DTXSID8045646 Css NA 1.622 mg/L 3compartmentss NA 95% Human Human +DTXSID8045646 Css NA 0.1386 mg/L PBTK NA 50% Human Human +DTXSID8045646 Css NA 1.024 mg/L PBTK NA 95% Human Human +DTXSID8045646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045646 Fup 0.132 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045646 Vd NA 0.8872 L/kg 1compartment NA NA Rat Human +DTXSID8045646 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8045646 TK.Half.Life NA 1.051 hours 1compartment NA NA Rat Human +DTXSID8045646 Css NA 0.02734 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045646 Css NA 0.1588 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045646 Css NA 0.0179 mg/L PBTK NA 50% Rat Human +DTXSID8045646 Css NA 0.09849 mg/L PBTK NA 95% Rat Human +DTXSID8045648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045648 Fup 0.797 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045648 Vd NA 0.6313 L/kg 1compartment NA NA Human Human DTXSID8045648 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045648 TK.Half.Life NA 1.441 hours 1compartment NA NA Human Human -DTXSID8045648 Css NA 0.2222 mg/L 3compartmentss NA 50% Human Human -DTXSID8045648 Css NA 1.586 mg/L 3compartmentss NA 95% Human Human -DTXSID8045648 Css NA 0.1824 mg/L PBTK NA 50% Human Human -DTXSID8045648 Css NA 1.073 mg/L PBTK NA 95% Human Human -DTXSID8045648 Clint NA 1.733 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045648 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045648 Vd NA 0.7744 L/kg 1compartment NA NA Rat Human +DTXSID8045648 TK.Half.Life NA 5.127 hours 1compartment NA NA Human Human +DTXSID8045648 Css NA 0.8737 mg/L 3compartmentss NA 50% Human Human +DTXSID8045648 Css NA 5.318 mg/L 3compartmentss NA 95% Human Human +DTXSID8045648 Css NA 0.6998 mg/L PBTK NA 50% Human Human +DTXSID8045648 Css NA 3.378 mg/L PBTK NA 95% Human Human +DTXSID8045648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045648 Fup 0.797 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045648 Vd NA 0.6709 L/kg 1compartment NA NA Rat Human DTXSID8045648 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045648 TK.Half.Life NA 0.7752 hours 1compartment NA NA Rat Human -DTXSID8045648 Css NA 0.09032 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045648 Css NA 0.5673 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045648 Css NA 0.07367 mg/L PBTK NA 50% Rat Human -DTXSID8045648 Css NA 0.3462 mg/L PBTK NA 95% Rat Human -DTXSID8045690 Clint NA 139.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045690 Fup NA 0.1285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045690 Vd NA 2.622 L/kg 1compartment NA NA Human Human +DTXSID8045648 TK.Half.Life NA 1.856 hours 1compartment NA NA Rat Human +DTXSID8045648 Css NA 0.01658 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045648 Css NA 0.1277 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045648 Css NA 0.0127 mg/L PBTK NA 50% Rat Human +DTXSID8045648 Css NA 0.08079 mg/L PBTK NA 95% Rat Human +DTXSID8045690 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045690 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045690 Vd NA 0.9836 L/kg 1compartment NA NA Human Human DTXSID8045690 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045690 TK.Half.Life NA 2.418 hours 1compartment NA NA Human Human -DTXSID8045690 Css NA 0.03144 mg/L 3compartmentss NA 50% Human Human -DTXSID8045690 Css NA 0.2625 mg/L 3compartmentss NA 95% Human Human -DTXSID8045690 Css NA 0.02479 mg/L PBTK NA 50% Human Human -DTXSID8045690 Css NA 0.189 mg/L PBTK NA 95% Human Human -DTXSID8045690 Clint NA 139.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045690 Fup NA 0.1285 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045690 Vd NA 2.287 L/kg 1compartment NA NA Rat Human +DTXSID8045690 TK.Half.Life NA 2.792 hours 1compartment NA NA Human Human +DTXSID8045690 Css NA 0.2511 mg/L 3compartmentss NA 50% Human Human +DTXSID8045690 Css NA 1.518 mg/L 3compartmentss NA 95% Human Human +DTXSID8045690 Css NA 0.187 mg/L PBTK NA 50% Human Human +DTXSID8045690 Css NA 1.018 mg/L PBTK NA 95% Human Human +DTXSID8045690 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045690 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045690 Vd NA 0.9838 L/kg 1compartment NA NA Rat Human DTXSID8045690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045690 TK.Half.Life NA 0.955 hours 1compartment NA NA Rat Human -DTXSID8045690 Css NA 0.01725 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045690 Css NA 0.1147 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045690 Css NA 0.01306 mg/L PBTK NA 50% Rat Human -DTXSID8045690 Css NA 0.08054 mg/L PBTK NA 95% Rat Human -DTXSID8045692 Clint NA 3.185 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8045690 TK.Half.Life NA 1.625 hours 1compartment NA NA Rat Human +DTXSID8045690 Css NA 0.02931 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045690 Css NA 0.1344 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045690 Css NA 0.02188 mg/L PBTK NA 50% Rat Human +DTXSID8045690 Css NA 0.08773 mg/L PBTK NA 95% Rat Human +DTXSID8045692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8045692 Fup 0.76 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8045692 Vd NA 0.8181 L/kg 1compartment NA NA Human Human +DTXSID8045692 Vd NA 0.8541 L/kg 1compartment NA NA Human Human DTXSID8045692 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045692 TK.Half.Life NA 1.464 hours 1compartment NA NA Human Human -DTXSID8045692 Css NA 0.1702 mg/L 3compartmentss NA 50% Human Human -DTXSID8045692 Css NA 1.352 mg/L 3compartmentss NA 95% Human Human -DTXSID8045692 Css NA 0.14 mg/L PBTK NA 50% Human Human -DTXSID8045692 Css NA 0.9037 mg/L PBTK NA 95% Human Human -DTXSID8045692 Clint NA 3.185 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8045692 TK.Half.Life NA 0.6769 hours 1compartment NA NA Human Human +DTXSID8045692 Css NA 0.02682 mg/L 3compartmentss NA 50% Human Human +DTXSID8045692 Css NA 0.2889 mg/L 3compartmentss NA 95% Human Human +DTXSID8045692 Css NA 0.02222 mg/L PBTK NA 50% Human Human +DTXSID8045692 Css NA 0.2012 mg/L PBTK NA 95% Human Human +DTXSID8045692 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8045692 Fup 0.76 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8045692 Vd NA 0.8244 L/kg 1compartment NA NA Rat Human +DTXSID8045692 Vd NA 0.8531 L/kg 1compartment NA NA Rat Human DTXSID8045692 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045692 TK.Half.Life NA 0.7842 hours 1compartment NA NA Rat Human -DTXSID8045692 Css NA 0.07524 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045692 Css NA 0.5488 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045692 Css NA 0.06145 mg/L PBTK NA 50% Rat Human -DTXSID8045692 Css NA 0.3306 mg/L PBTK NA 95% Rat Human -DTXSID8045694 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045694 Fup NA 0.011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045694 Vd NA 0.196 L/kg 1compartment NA NA Human Human -DTXSID8045694 Days.Css NA 25 Days PBTK NA NA Human Human -DTXSID8045694 TK.Half.Life NA 115.4 hours 1compartment NA NA Human Human -DTXSID8045694 Css NA 102.2 mg/L 3compartmentss NA 50% Human Human -DTXSID8045694 Css NA 627 mg/L 3compartmentss NA 95% Human Human -DTXSID8045694 Css NA 59.78 mg/L PBTK NA 50% Human Human -DTXSID8045694 Css NA 365.4 mg/L PBTK NA 95% Human Human -DTXSID8045694 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045694 Fup NA 0.011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045694 Vd NA 0.1859 L/kg 1compartment NA NA Rat Human -DTXSID8045694 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID8045694 TK.Half.Life NA 37.27 hours 1compartment NA NA Rat Human -DTXSID8045694 Css NA 28.88 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045694 Css NA 151.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045694 Css NA 15.74 mg/L PBTK NA 50% Rat Human -DTXSID8045694 Css NA 82.07 mg/L PBTK NA 95% Rat Human +DTXSID8045692 TK.Half.Life NA 0.3293 hours 1compartment NA NA Rat Human +DTXSID8045692 Css NA 0.003156 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045692 Css NA 0.03045 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045692 Css NA 0.002676 mg/L PBTK NA 50% Rat Human +DTXSID8045692 Css NA 0.02028 mg/L PBTK NA 95% Rat Human +DTXSID8045694 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045694 Fup 0.0502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045694 Vd NA 0.3893 L/kg 1compartment NA NA Human Human +DTXSID8045694 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045694 TK.Half.Life NA 1.664 hours 1compartment NA NA Human Human +DTXSID8045694 Css NA 0.6018 mg/L 3compartmentss NA 50% Human Human +DTXSID8045694 Css NA 5.158 mg/L 3compartmentss NA 95% Human Human +DTXSID8045694 Css NA 0.3657 mg/L PBTK NA 50% Human Human +DTXSID8045694 Css NA 3.087 mg/L PBTK NA 95% Human Human +DTXSID8045694 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045694 Fup 0.0502 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045694 Vd NA 0.3361 L/kg 1compartment NA NA Rat Human +DTXSID8045694 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8045694 TK.Half.Life NA 0.8943 hours 1compartment NA NA Rat Human +DTXSID8045694 Css NA 0.07907 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045694 Css NA 0.5129 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045694 Css NA 0.04698 mg/L PBTK NA 50% Rat Human +DTXSID8045694 Css NA 0.2959 mg/L PBTK NA 95% Rat Human DTXSID8045696 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8045696 Fup NA 0.6436 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045696 Vd NA 0.6211 L/kg 1compartment NA NA Human Human +DTXSID8045696 Vd NA 0.5599 L/kg 1compartment NA NA Human Human DTXSID8045696 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045696 TK.Half.Life NA 6.245 hours 1compartment NA NA Human Human -DTXSID8045696 Css NA 1.169 mg/L 3compartmentss NA 50% Human Human -DTXSID8045696 Css NA 7.534 mg/L 3compartmentss NA 95% Human Human -DTXSID8045696 Css NA 0.9284 mg/L PBTK NA 50% Human Human -DTXSID8045696 Css NA 4.766 mg/L PBTK NA 95% Human Human +DTXSID8045696 TK.Half.Life NA 5.631 hours 1compartment NA NA Human Human +DTXSID8045696 Css NA 1.022 mg/L 3compartmentss NA 50% Human Human +DTXSID8045696 Css NA 6.584 mg/L 3compartmentss NA 95% Human Human +DTXSID8045696 Css NA 0.7892 mg/L PBTK NA 50% Human Human +DTXSID8045696 Css NA 4.083 mg/L PBTK NA 95% Human Human DTXSID8045696 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8045696 Fup NA 0.6436 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045696 Vd NA 0.6476 L/kg 1compartment NA NA Rat Human +DTXSID8045696 Vd NA 0.594 L/kg 1compartment NA NA Rat Human DTXSID8045696 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045696 TK.Half.Life NA 2.219 hours 1compartment NA NA Rat Human -DTXSID8045696 Css NA 0.3055 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045696 Css NA 1.861 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045696 Css NA 0.2333 mg/L PBTK NA 50% Rat Human -DTXSID8045696 Css NA 1.094 mg/L PBTK NA 95% Rat Human -DTXSID8045698 Clint NA 5.272 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045698 Fup NA 0.0975 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045698 Vd NA 0.9249 L/kg 1compartment NA NA Human Human +DTXSID8045696 TK.Half.Life NA 2.035 hours 1compartment NA NA Rat Human +DTXSID8045696 Css NA 0.01964 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045696 Css NA 0.1568 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045696 Css NA 0.01456 mg/L PBTK NA 50% Rat Human +DTXSID8045696 Css NA 0.09872 mg/L PBTK NA 95% Rat Human +DTXSID8045698 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045698 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045698 Vd NA 1.207 L/kg 1compartment NA NA Human Human DTXSID8045698 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045698 TK.Half.Life NA 7.078 hours 1compartment NA NA Human Human -DTXSID8045698 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human -DTXSID8045698 Css NA 7.301 mg/L 3compartmentss NA 95% Human Human -DTXSID8045698 Css NA 0.7236 mg/L PBTK NA 50% Human Human -DTXSID8045698 Css NA 4.406 mg/L PBTK NA 95% Human Human -DTXSID8045698 Clint NA 5.272 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045698 Fup NA 0.0975 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045698 Vd NA 0.7522 L/kg 1compartment NA NA Rat Human +DTXSID8045698 TK.Half.Life NA 4.106 hours 1compartment NA NA Human Human +DTXSID8045698 Css NA 0.3266 mg/L 3compartmentss NA 50% Human Human +DTXSID8045698 Css NA 1.838 mg/L 3compartmentss NA 95% Human Human +DTXSID8045698 Css NA 0.2363 mg/L PBTK NA 50% Human Human +DTXSID8045698 Css NA 1.233 mg/L PBTK NA 95% Human Human +DTXSID8045698 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045698 Fup 0.222 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045698 Vd NA 1.013 L/kg 1compartment NA NA Rat Human DTXSID8045698 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045698 TK.Half.Life NA 3.291 hours 1compartment NA NA Rat Human -DTXSID8045698 Css NA 0.5797 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045698 Css NA 2.892 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045698 Css NA 0.3542 mg/L PBTK NA 50% Rat Human -DTXSID8045698 Css NA 1.653 mg/L PBTK NA 95% Rat Human -DTXSID8045771 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045771 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045771 Vd NA 1.272 L/kg 1compartment NA NA Human Human -DTXSID8045771 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID8045771 TK.Half.Life NA 109.8 hours 1compartment NA NA Human Human -DTXSID8045771 Css NA 12.38 mg/L 3compartmentss NA 50% Human Human -DTXSID8045771 Css NA 58.06 mg/L 3compartmentss NA 95% Human Human -DTXSID8045771 Css NA 8.525 mg/L PBTK NA 50% Human Human -DTXSID8045771 Css NA 35.57 mg/L PBTK NA 95% Human Human -DTXSID8045771 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045771 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045771 Vd NA 1.224 L/kg 1compartment NA NA Rat Human -DTXSID8045771 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID8045771 TK.Half.Life NA 35.2 hours 1compartment NA NA Rat Human -DTXSID8045771 Css NA 3.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045771 Css NA 13.99 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045771 Css NA 2.226 mg/L PBTK NA 50% Rat Human -DTXSID8045771 Css NA 8 mg/L PBTK NA 95% Rat Human -DTXSID8045773 Clint NA 7.465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045773 Fup NA 0.7407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045773 Vd NA 4.582 L/kg 1compartment NA NA Human Human +DTXSID8045698 TK.Half.Life NA 1.872 hours 1compartment NA NA Rat Human +DTXSID8045698 Css NA 0.03817 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045698 Css NA 0.1646 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045698 Css NA 0.02738 mg/L PBTK NA 50% Rat Human +DTXSID8045698 Css NA 0.1076 mg/L PBTK NA 95% Rat Human +DTXSID8045771 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045771 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045771 Vd NA 1.581 L/kg 1compartment NA NA Human Human +DTXSID8045771 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045771 TK.Half.Life NA 4.138 hours 1compartment NA NA Human Human +DTXSID8045771 Css NA 0.2091 mg/L 3compartmentss NA 50% Human Human +DTXSID8045771 Css NA 1.322 mg/L 3compartmentss NA 95% Human Human +DTXSID8045771 Css NA 0.1746 mg/L PBTK NA 50% Human Human +DTXSID8045771 Css NA 0.9597 mg/L PBTK NA 95% Human Human +DTXSID8045771 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045771 Fup 0.271 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045771 Vd NA 1.583 L/kg 1compartment NA NA Rat Human +DTXSID8045771 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8045771 TK.Half.Life NA 2.418 hours 1compartment NA NA Rat Human +DTXSID8045771 Css NA 0.02454 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045771 Css NA 0.1197 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045771 Css NA 0.02058 mg/L PBTK NA 50% Rat Human +DTXSID8045771 Css NA 0.08476 mg/L PBTK NA 95% Rat Human +DTXSID8045773 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045773 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045773 Vd NA 2.824 L/kg 1compartment NA NA Human Human DTXSID8045773 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045773 TK.Half.Life NA 4.186 hours 1compartment NA NA Human Human -DTXSID8045773 Css NA 0.04679 mg/L 3compartmentss NA 50% Human Human -DTXSID8045773 Css NA 0.5071 mg/L 3compartmentss NA 95% Human Human -DTXSID8045773 Css NA 0.06673 mg/L PBTK NA 50% Human Human -DTXSID8045773 Css NA 0.4713 mg/L PBTK NA 95% Human Human -DTXSID8045773 Clint NA 7.465 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045773 Fup NA 0.7407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045773 Vd NA 4.691 L/kg 1compartment NA NA Rat Human +DTXSID8045773 TK.Half.Life NA 6.25 hours 1compartment NA NA Human Human +DTXSID8045773 Css NA 0.1438 mg/L 3compartmentss NA 50% Human Human +DTXSID8045773 Css NA 1.057 mg/L 3compartmentss NA 95% Human Human +DTXSID8045773 Css NA 0.1514 mg/L PBTK NA 50% Human Human +DTXSID8045773 Css NA 0.8892 mg/L PBTK NA 95% Human Human +DTXSID8045773 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045773 Fup 0.297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045773 Vd NA 2.858 L/kg 1compartment NA NA Rat Human DTXSID8045773 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045773 TK.Half.Life NA 2.408 hours 1compartment NA NA Rat Human -DTXSID8045773 Css NA 0.02154 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045773 Css NA 0.2312 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045773 Css NA 0.03184 mg/L PBTK NA 50% Rat Human -DTXSID8045773 Css NA 0.1878 mg/L PBTK NA 95% Rat Human -DTXSID8045775 Clint NA 26.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045775 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045775 Vd NA 0.2969 L/kg 1compartment NA NA Human Human +DTXSID8045773 TK.Half.Life NA 3.717 hours 1compartment NA NA Rat Human +DTXSID8045773 Css NA 0.0165 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045773 Css NA 0.0922 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045773 Css NA 0.01781 mg/L PBTK NA 50% Rat Human +DTXSID8045773 Css NA 0.07376 mg/L PBTK NA 95% Rat Human +DTXSID8045775 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045775 Fup 0.0198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045775 Vd NA 0.4403 L/kg 1compartment NA NA Human Human DTXSID8045775 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045775 TK.Half.Life NA 8.658 hours 1compartment NA NA Human Human -DTXSID8045775 Css NA 5.36 mg/L 3compartmentss NA 50% Human Human -DTXSID8045775 Css NA 52.61 mg/L 3compartmentss NA 95% Human Human -DTXSID8045775 Css NA 3.156 mg/L PBTK NA 50% Human Human -DTXSID8045775 Css NA 30.53 mg/L PBTK NA 95% Human Human -DTXSID8045775 Clint NA 26.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045775 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045775 Vd NA 0.2622 L/kg 1compartment NA NA Rat Human +DTXSID8045775 TK.Half.Life NA 4.101 hours 1compartment NA NA Human Human +DTXSID8045775 Css NA 1.506 mg/L 3compartmentss NA 50% Human Human +DTXSID8045775 Css NA 14.89 mg/L 3compartmentss NA 95% Human Human +DTXSID8045775 Css NA 0.9382 mg/L PBTK NA 50% Human Human +DTXSID8045775 Css NA 8.865 mg/L PBTK NA 95% Human Human +DTXSID8045775 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045775 Fup 0.0198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045775 Vd NA 0.4039 L/kg 1compartment NA NA Rat Human DTXSID8045775 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045775 TK.Half.Life NA 5.165 hours 1compartment NA NA Rat Human -DTXSID8045775 Css NA 3.039 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045775 Css NA 24.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045775 Css NA 1.681 mg/L PBTK NA 50% Rat Human -DTXSID8045775 Css NA 13.42 mg/L PBTK NA 95% Rat Human -DTXSID8045777 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045777 Fup NA 0.6502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045777 Vd NA 0.5744 L/kg 1compartment NA NA Human Human +DTXSID8045775 TK.Half.Life NA 2.464 hours 1compartment NA NA Rat Human +DTXSID8045775 Css NA 0.1949 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045775 Css NA 1.632 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045775 Css NA 0.1177 mg/L PBTK NA 50% Rat Human +DTXSID8045775 Css NA 0.9556 mg/L PBTK NA 95% Rat Human +DTXSID8045777 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045777 Fup 0.868 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045777 Vd NA 0.6882 L/kg 1compartment NA NA Human Human DTXSID8045777 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045777 TK.Half.Life NA 5.714 hours 1compartment NA NA Human Human -DTXSID8045777 Css NA 1.196 mg/L 3compartmentss NA 50% Human Human -DTXSID8045777 Css NA 7.593 mg/L 3compartmentss NA 95% Human Human -DTXSID8045777 Css NA 0.9248 mg/L PBTK NA 50% Human Human -DTXSID8045777 Css NA 4.734 mg/L PBTK NA 95% Human Human -DTXSID8045777 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045777 Fup NA 0.6502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045777 Vd NA 0.607 L/kg 1compartment NA NA Rat Human +DTXSID8045777 TK.Half.Life NA 5.131 hours 1compartment NA NA Human Human +DTXSID8045777 Css NA 0.5262 mg/L 3compartmentss NA 50% Human Human +DTXSID8045777 Css NA 3.145 mg/L 3compartmentss NA 95% Human Human +DTXSID8045777 Css NA 0.4281 mg/L PBTK NA 50% Human Human +DTXSID8045777 Css NA 2.061 mg/L PBTK NA 95% Human Human +DTXSID8045777 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045777 Fup 0.868 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045777 Vd NA 0.7261 L/kg 1compartment NA NA Rat Human DTXSID8045777 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045777 TK.Half.Life NA 2.059 hours 1compartment NA NA Rat Human -DTXSID8045777 Css NA 0.3114 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045777 Css NA 1.885 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045777 Css NA 0.2322 mg/L PBTK NA 50% Rat Human -DTXSID8045777 Css NA 1.1 mg/L PBTK NA 95% Rat Human +DTXSID8045777 TK.Half.Life NA 1.844 hours 1compartment NA NA Rat Human +DTXSID8045777 Css NA 0.002692 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045777 Css NA 0.01754 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045777 Css NA 0.002128 mg/L PBTK NA 50% Rat Human +DTXSID8045777 Css NA 0.01079 mg/L PBTK NA 95% Rat Human DTXSID8045779 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8045779 Fup NA 0.6523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045779 Vd NA 1.59 L/kg 1compartment NA NA Human Human +DTXSID8045779 Vd NA 1.356 L/kg 1compartment NA NA Human Human DTXSID8045779 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8045779 TK.Half.Life NA 15.77 hours 1compartment NA NA Human Human -DTXSID8045779 Css NA 0.9765 mg/L 3compartmentss NA 50% Human Human -DTXSID8045779 Css NA 6.966 mg/L 3compartmentss NA 95% Human Human -DTXSID8045779 Css NA 0.9198 mg/L PBTK NA 50% Human Human -DTXSID8045779 Css NA 4.672 mg/L PBTK NA 95% Human Human +DTXSID8045779 TK.Half.Life NA 13.45 hours 1compartment NA NA Human Human +DTXSID8045779 Css NA 0.8603 mg/L 3compartmentss NA 50% Human Human +DTXSID8045779 Css NA 6.004 mg/L 3compartmentss NA 95% Human Human +DTXSID8045779 Css NA 0.7845 mg/L PBTK NA 50% Human Human +DTXSID8045779 Css NA 3.989 mg/L PBTK NA 95% Human Human DTXSID8045779 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8045779 Fup NA 0.6523 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045779 Vd NA 1.616 L/kg 1compartment NA NA Rat Human +DTXSID8045779 Vd NA 1.387 L/kg 1compartment NA NA Rat Human DTXSID8045779 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045779 TK.Half.Life NA 5.462 hours 1compartment NA NA Rat Human -DTXSID8045779 Css NA 0.2534 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045779 Css NA 1.789 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045779 Css NA 0.233 mg/L PBTK NA 50% Rat Human -DTXSID8045779 Css NA 1.109 mg/L PBTK NA 95% Rat Human -DTXSID8045800 Clint NA 353.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045800 Fup NA 0.2344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045800 Vd NA 1.931 L/kg 1compartment NA NA Human Human +DTXSID8045779 TK.Half.Life NA 4.687 hours 1compartment NA NA Rat Human +DTXSID8045779 Css NA 0.01643 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045779 Css NA 0.1381 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045779 Css NA 0.01447 mg/L PBTK NA 50% Rat Human +DTXSID8045779 Css NA 0.09369 mg/L PBTK NA 95% Rat Human +DTXSID8045800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045800 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045800 Vd NA 2.244 L/kg 1compartment NA NA Human Human DTXSID8045800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045800 TK.Half.Life NA 1.184 hours 1compartment NA NA Human Human -DTXSID8045800 Css NA 0.00378 mg/L 3compartmentss NA 50% Human Human -DTXSID8045800 Css NA 0.03194 mg/L 3compartmentss NA 95% Human Human -DTXSID8045800 Css NA 0.003578 mg/L PBTK NA 50% Human Human -DTXSID8045800 Css NA 0.02593 mg/L PBTK NA 95% Human Human -DTXSID8045800 Clint NA 353.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045800 Fup NA 0.2344 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045800 Vd NA 1.902 L/kg 1compartment NA NA Rat Human +DTXSID8045800 TK.Half.Life NA 5.1 hours 1compartment NA NA Human Human +DTXSID8045800 Css NA 0.1505 mg/L 3compartmentss NA 50% Human Human +DTXSID8045800 Css NA 1.077 mg/L 3compartmentss NA 95% Human Human +DTXSID8045800 Css NA 0.1535 mg/L PBTK NA 50% Human Human +DTXSID8045800 Css NA 0.8898 mg/L PBTK NA 95% Human Human +DTXSID8045800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045800 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045800 Vd NA 2.217 L/kg 1compartment NA NA Rat Human DTXSID8045800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045800 TK.Half.Life NA 0.5275 hours 1compartment NA NA Rat Human -DTXSID8045800 Css NA 0.002069 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045800 Css NA 0.01478 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045800 Css NA 0.00192 mg/L PBTK NA 50% Rat Human -DTXSID8045800 Css NA 0.01131 mg/L PBTK NA 95% Rat Human -DTXSID8045802 Clint NA 13.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045802 Fup NA 0.098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045802 Vd NA 3.665 L/kg 1compartment NA NA Human Human +DTXSID8045800 TK.Half.Life NA 2.998 hours 1compartment NA NA Rat Human +DTXSID8045800 Css NA 0.01756 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045800 Css NA 0.09669 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045800 Css NA 0.01839 mg/L PBTK NA 50% Rat Human +DTXSID8045800 Css NA 0.07567 mg/L PBTK NA 95% Rat Human +DTXSID8045802 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045802 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045802 Vd NA 3.452 L/kg 1compartment NA NA Human Human DTXSID8045802 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045802 TK.Half.Life NA 6.539 hours 1compartment NA NA Human Human -DTXSID8045802 Css NA 0.1342 mg/L 3compartmentss NA 50% Human Human -DTXSID8045802 Css NA 1.154 mg/L 3compartmentss NA 95% Human Human -DTXSID8045802 Css NA 0.1307 mg/L PBTK NA 50% Human Human -DTXSID8045802 Css NA 0.9365 mg/L PBTK NA 95% Human Human -DTXSID8045802 Clint NA 13.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045802 Fup NA 0.098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045802 Vd NA 3.45 L/kg 1compartment NA NA Rat Human +DTXSID8045802 TK.Half.Life NA 4.687 hours 1compartment NA NA Human Human +DTXSID8045802 Css NA 0.0869 mg/L 3compartmentss NA 50% Human Human +DTXSID8045802 Css NA 0.7763 mg/L 3compartmentss NA 95% Human Human +DTXSID8045802 Css NA 0.08369 mg/L PBTK NA 50% Human Human +DTXSID8045802 Css NA 0.6404 mg/L PBTK NA 95% Human Human +DTXSID8045802 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045802 Fup 0.105 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045802 Vd NA 3.322 L/kg 1compartment NA NA Rat Human DTXSID8045802 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045802 TK.Half.Life NA 3.041 hours 1compartment NA NA Rat Human -DTXSID8045802 Css NA 0.07258 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045802 Css NA 0.5215 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045802 Css NA 0.06886 mg/L PBTK NA 50% Rat Human -DTXSID8045802 Css NA 0.4037 mg/L PBTK NA 95% Rat Human -DTXSID8045804 Clint NA 19.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045804 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045804 Vd NA 3.055 L/kg 1compartment NA NA Human Human -DTXSID8045804 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8045804 TK.Half.Life NA 17.16 hours 1compartment NA NA Human Human -DTXSID8045804 Css NA 0.641 mg/L 3compartmentss NA 50% Human Human -DTXSID8045804 Css NA 4.345 mg/L 3compartmentss NA 95% Human Human -DTXSID8045804 Css NA 0.4479 mg/L PBTK NA 50% Human Human -DTXSID8045804 Css NA 2.887 mg/L PBTK NA 95% Human Human -DTXSID8045804 Clint NA 19.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045804 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045804 Vd NA 2.336 L/kg 1compartment NA NA Rat Human +DTXSID8045802 TK.Half.Life NA 2.359 hours 1compartment NA NA Rat Human +DTXSID8045802 Css NA 0.01088 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045802 Css NA 0.08556 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045802 Css NA 0.01063 mg/L PBTK NA 50% Rat Human +DTXSID8045802 Css NA 0.06793 mg/L PBTK NA 95% Rat Human +DTXSID8045804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045804 Fup 0.0634 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045804 Vd NA 1.276 L/kg 1compartment NA NA Human Human +DTXSID8045804 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045804 TK.Half.Life NA 4.075 hours 1compartment NA NA Human Human +DTXSID8045804 Css NA 0.3763 mg/L 3compartmentss NA 50% Human Human +DTXSID8045804 Css NA 3.091 mg/L 3compartmentss NA 95% Human Human +DTXSID8045804 Css NA 0.2582 mg/L PBTK NA 50% Human Human +DTXSID8045804 Css NA 1.964 mg/L PBTK NA 95% Human Human +DTXSID8045804 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045804 Fup 0.0634 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045804 Vd NA 1.219 L/kg 1compartment NA NA Rat Human DTXSID8045804 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045804 TK.Half.Life NA 3.363 hours 1compartment NA NA Rat Human -DTXSID8045804 Css NA 0.3622 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045804 Css NA 2.039 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045804 Css NA 0.2426 mg/L PBTK NA 50% Rat Human -DTXSID8045804 Css NA 1.31 mg/L PBTK NA 95% Rat Human -DTXSID8045806 Clint NA 292.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045806 Fup NA 0.0129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045806 Vd NA 0.4736 L/kg 1compartment NA NA Human Human +DTXSID8045804 TK.Half.Life NA 2.367 hours 1compartment NA NA Rat Human +DTXSID8045804 Css NA 0.04893 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045804 Css NA 0.3225 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045804 Css NA 0.03267 mg/L PBTK NA 50% Rat Human +DTXSID8045804 Css NA 0.198 mg/L PBTK NA 95% Rat Human +DTXSID8045806 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045806 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045806 Vd NA 2.704 L/kg 1compartment NA NA Human Human DTXSID8045806 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045806 TK.Half.Life NA 0.8655 hours 1compartment NA NA Human Human -DTXSID8045806 Css NA 0.1682 mg/L 3compartmentss NA 50% Human Human -DTXSID8045806 Css NA 1.733 mg/L 3compartmentss NA 95% Human Human -DTXSID8045806 Css NA 0.1011 mg/L PBTK NA 50% Human Human -DTXSID8045806 Css NA 1.042 mg/L PBTK NA 95% Human Human -DTXSID8045806 Clint NA 292.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045806 Fup NA 0.0129 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045806 Vd NA 0.4545 L/kg 1compartment NA NA Rat Human +DTXSID8045806 TK.Half.Life NA 3.683 hours 1compartment NA NA Human Human +DTXSID8045806 Css NA 0.07241 mg/L 3compartmentss NA 50% Human Human +DTXSID8045806 Css NA 0.5777 mg/L 3compartmentss NA 95% Human Human +DTXSID8045806 Css NA 0.06994 mg/L PBTK NA 50% Human Human +DTXSID8045806 Css NA 0.4724 mg/L PBTK NA 95% Human Human +DTXSID8045806 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045806 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045806 Vd NA 2.71 L/kg 1compartment NA NA Rat Human DTXSID8045806 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045806 TK.Half.Life NA 0.4687 hours 1compartment NA NA Rat Human -DTXSID8045806 Css NA 0.09688 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045806 Css NA 0.8991 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045806 Css NA 0.05468 mg/L PBTK NA 50% Rat Human -DTXSID8045806 Css NA 0.4931 mg/L PBTK NA 95% Rat Human -DTXSID8045850 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045850 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045850 Vd NA 0.5374 L/kg 1compartment NA NA Human Human +DTXSID8045806 TK.Half.Life NA 2.1 hours 1compartment NA NA Rat Human +DTXSID8045806 Css NA 0.008888 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045806 Css NA 0.05557 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045806 Css NA 0.008877 mg/L PBTK NA 50% Rat Human +DTXSID8045806 Css NA 0.04505 mg/L PBTK NA 95% Rat Human +DTXSID80458181 Clint 54.95 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80458181 Fup 0.0874 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80458181 Vd NA 1.886 L/kg 1compartment NA NA Human Human +DTXSID80458181 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80458181 TK.Half.Life NA 2.164 hours 1compartment NA NA Human Human +DTXSID80458181 Css NA 0.06321 mg/L 3compartmentss NA 50% Human Human +DTXSID80458181 Css NA 0.636 mg/L 3compartmentss NA 95% Human Human +DTXSID80458181 Css NA 0.05164 mg/L PBTK NA 50% Human Human +DTXSID80458181 Css NA 0.4423 mg/L PBTK NA 95% Human Human +DTXSID80458181 Clint 54.95 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80458181 Fup 0.0874 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80458181 Vd NA 1.863 L/kg 1compartment NA NA Rat Human +DTXSID80458181 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80458181 TK.Half.Life NA 1.17 hours 1compartment NA NA Rat Human +DTXSID80458181 Css NA 0.008382 mg/L 3compartmentss NA 50% Rat Human +DTXSID80458181 Css NA 0.06756 mg/L 3compartmentss NA 95% Rat Human +DTXSID80458181 Css NA 0.006779 mg/L PBTK NA 50% Rat Human +DTXSID80458181 Css NA 0.04708 mg/L PBTK NA 95% Rat Human +DTXSID8045850 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045850 Fup 0.909 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045850 Vd NA 0.4323 L/kg 1compartment NA NA Human Human DTXSID8045850 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045850 TK.Half.Life NA 3.478 hours 1compartment NA NA Human Human -DTXSID8045850 Css NA 0.9108 mg/L 3compartmentss NA 50% Human Human -DTXSID8045850 Css NA 5.658 mg/L 3compartmentss NA 95% Human Human -DTXSID8045850 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID8045850 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID8045850 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045850 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045850 Vd NA 0.5578 L/kg 1compartment NA NA Rat Human +DTXSID8045850 TK.Half.Life NA 3.077 hours 1compartment NA NA Human Human +DTXSID8045850 Css NA 0.8922 mg/L 3compartmentss NA 50% Human Human +DTXSID8045850 Css NA 4.57 mg/L 3compartmentss NA 95% Human Human +DTXSID8045850 Css NA 0.6491 mg/L PBTK NA 50% Human Human +DTXSID8045850 Css NA 2.829 mg/L PBTK NA 95% Human Human +DTXSID8045850 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045850 Fup 0.909 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045850 Vd NA 0.4622 L/kg 1compartment NA NA Rat Human DTXSID8045850 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045850 TK.Half.Life NA 1.23 hours 1compartment NA NA Rat Human -DTXSID8045850 Css NA 0.231 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045850 Css NA 1.347 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045850 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID8045850 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID8045852 Clint NA 0.8604 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045852 Fup NA 0.6656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045852 Vd NA 0.9418 L/kg 1compartment NA NA Human Human +DTXSID8045850 TK.Half.Life NA 1.121 hours 1compartment NA NA Rat Human +DTXSID8045850 Css NA 0.01662 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045850 Css NA 0.1143 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045850 Css NA 0.01164 mg/L PBTK NA 50% Rat Human +DTXSID8045850 Css NA 0.07161 mg/L PBTK NA 95% Rat Human +DTXSID8045852 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045852 Fup 0.739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045852 Vd NA 0.6509 L/kg 1compartment NA NA Human Human DTXSID8045852 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045852 TK.Half.Life NA 4.009 hours 1compartment NA NA Human Human -DTXSID8045852 Css NA 0.4488 mg/L 3compartmentss NA 50% Human Human -DTXSID8045852 Css NA 3.244 mg/L 3compartmentss NA 95% Human Human -DTXSID8045852 Css NA 0.3808 mg/L PBTK NA 50% Human Human -DTXSID8045852 Css NA 2.091 mg/L PBTK NA 95% Human Human -DTXSID8045852 Clint NA 0.8604 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045852 Fup NA 0.6656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045852 Vd NA 0.9358 L/kg 1compartment NA NA Rat Human +DTXSID8045852 TK.Half.Life NA 0.8366 hours 1compartment NA NA Human Human +DTXSID8045852 Css NA 0.09308 mg/L 3compartmentss NA 50% Human Human +DTXSID8045852 Css NA 0.811 mg/L 3compartmentss NA 95% Human Human +DTXSID8045852 Css NA 0.07303 mg/L PBTK NA 50% Human Human +DTXSID8045852 Css NA 0.5445 mg/L PBTK NA 95% Human Human +DTXSID8045852 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045852 Fup 0.739 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045852 Vd NA 0.6895 L/kg 1compartment NA NA Rat Human DTXSID8045852 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045852 TK.Half.Life NA 1.877 hours 1compartment NA NA Rat Human -DTXSID8045852 Css NA 0.166 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045852 Css NA 1.142 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045852 Css NA 0.137 mg/L PBTK NA 50% Rat Human -DTXSID8045852 Css NA 0.6877 mg/L PBTK NA 95% Rat Human -DTXSID8045854 Clint NA 98.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045854 Fup NA 0.0316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045854 Vd NA 1.9 L/kg 1compartment NA NA Human Human +DTXSID8045852 TK.Half.Life NA 0.4677 hours 1compartment NA NA Rat Human +DTXSID8045852 Css NA 0.01054 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045852 Css NA 0.07871 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045852 Css NA 0.00841 mg/L PBTK NA 50% Rat Human +DTXSID8045852 Css NA 0.0495 mg/L PBTK NA 95% Rat Human +DTXSID8045854 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045854 Fup 0.0979 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045854 Vd NA 1.463 L/kg 1compartment NA NA Human Human DTXSID8045854 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045854 TK.Half.Life NA 4.153 hours 1compartment NA NA Human Human -DTXSID8045854 Css NA 0.2228 mg/L 3compartmentss NA 50% Human Human -DTXSID8045854 Css NA 2.011 mg/L 3compartmentss NA 95% Human Human -DTXSID8045854 Css NA 0.1464 mg/L PBTK NA 50% Human Human -DTXSID8045854 Css NA 1.254 mg/L PBTK NA 95% Human Human -DTXSID8045854 Clint NA 98.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045854 Fup NA 0.0316 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045854 Vd NA 1.49 L/kg 1compartment NA NA Rat Human +DTXSID8045854 TK.Half.Life NA 9.826 hours 1compartment NA NA Human Human +DTXSID8045854 Css NA 0.878 mg/L 3compartmentss NA 50% Human Human +DTXSID8045854 Css NA 6.255 mg/L 3compartmentss NA 95% Human Human +DTXSID8045854 Css NA 0.6068 mg/L PBTK NA 50% Human Human +DTXSID8045854 Css NA 3.977 mg/L PBTK NA 95% Human Human +DTXSID8045854 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045854 Fup 0.0979 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045854 Vd NA 1.284 L/kg 1compartment NA NA Rat Human DTXSID8045854 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045854 TK.Half.Life NA 1.554 hours 1compartment NA NA Rat Human -DTXSID8045854 Css NA 0.1259 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045854 Css NA 0.9616 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045854 Css NA 0.07814 mg/L PBTK NA 50% Rat Human -DTXSID8045854 Css NA 0.5668 mg/L PBTK NA 95% Rat Human -DTXSID8045856 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045856 Fup NA 0.3304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045856 Vd NA 1.002 L/kg 1compartment NA NA Human Human -DTXSID8045856 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8045856 TK.Half.Life NA 20.96 hours 1compartment NA NA Human Human -DTXSID8045856 Css NA 2.304 mg/L 3compartmentss NA 50% Human Human -DTXSID8045856 Css NA 8.96 mg/L 3compartmentss NA 95% Human Human -DTXSID8045856 Css NA 1.728 mg/L PBTK NA 50% Human Human -DTXSID8045856 Css NA 5.826 mg/L PBTK NA 95% Human Human -DTXSID8045856 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045856 Fup NA 0.3304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045856 Vd NA 0.8879 L/kg 1compartment NA NA Rat Human +DTXSID8045854 TK.Half.Life NA 4.868 hours 1compartment NA NA Rat Human +DTXSID8045854 Css NA 0.1078 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045854 Css NA 0.5924 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045854 Css NA 0.07317 mg/L PBTK NA 50% Rat Human +DTXSID8045854 Css NA 0.3574 mg/L PBTK NA 95% Rat Human +DTXSID8045856 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045856 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045856 Vd NA 0.293 L/kg 1compartment NA NA Human Human +DTXSID8045856 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045856 TK.Half.Life NA 1.446 hours 1compartment NA NA Human Human +DTXSID8045856 Css NA 0.557 mg/L 3compartmentss NA 50% Human Human +DTXSID8045856 Css NA 4.025 mg/L 3compartmentss NA 95% Human Human +DTXSID8045856 Css NA 0.3494 mg/L PBTK NA 50% Human Human +DTXSID8045856 Css NA 2.438 mg/L PBTK NA 95% Human Human +DTXSID8045856 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045856 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045856 Vd NA 0.2898 L/kg 1compartment NA NA Rat Human DTXSID8045856 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045856 TK.Half.Life NA 6.022 hours 1compartment NA NA Rat Human -DTXSID8045856 Css NA 0.6276 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045856 Css NA 2.176 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045856 Css NA 0.4504 mg/L PBTK NA 50% Rat Human -DTXSID8045856 Css NA 1.308 mg/L PBTK NA 95% Rat Human -DTXSID8045933 Clint NA 14.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8045856 TK.Half.Life NA 0.8588 hours 1compartment NA NA Rat Human +DTXSID8045856 Css NA 0.01981 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045856 Css NA 0.1551 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045856 Css NA 0.01191 mg/L PBTK NA 50% Rat Human +DTXSID8045856 Css NA 0.09067 mg/L PBTK NA 95% Rat Human +DTXSID8045933 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8045933 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8045933 Vd NA 1.931 L/kg 1compartment NA NA Human Human -DTXSID8045933 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045933 TK.Half.Life NA 1.61 hours 1compartment NA NA Human Human -DTXSID8045933 Css NA 0.03831 mg/L 3compartmentss NA 50% Human Human -DTXSID8045933 Css NA 0.3678 mg/L 3compartmentss NA 95% Human Human -DTXSID8045933 Css NA 0.03699 mg/L PBTK NA 50% Human Human -DTXSID8045933 Css NA 0.2809 mg/L PBTK NA 95% Human Human -DTXSID8045933 Clint NA 14.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8045933 Vd NA 2.037 L/kg 1compartment NA NA Human Human +DTXSID8045933 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8045933 TK.Half.Life NA 19.61 hours 1compartment NA NA Human Human +DTXSID8045933 Css NA 0.8812 mg/L 3compartmentss NA 50% Human Human +DTXSID8045933 Css NA 6.319 mg/L 3compartmentss NA 95% Human Human +DTXSID8045933 Css NA 0.8732 mg/L PBTK NA 50% Human Human +DTXSID8045933 Css NA 4.286 mg/L PBTK NA 95% Human Human +DTXSID8045933 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8045933 Fup 0.75 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8045933 Vd NA 1.848 L/kg 1compartment NA NA Rat Human +DTXSID8045933 Vd NA 1.933 L/kg 1compartment NA NA Rat Human DTXSID8045933 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045933 TK.Half.Life NA 0.7693 hours 1compartment NA NA Rat Human -DTXSID8045933 Css NA 0.01863 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045933 Css NA 0.1714 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045933 Css NA 0.01813 mg/L PBTK NA 50% Rat Human -DTXSID8045933 Css NA 0.1219 mg/L PBTK NA 95% Rat Human -DTXSID8045935 Clint NA 4.664 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045935 Fup NA 0.4105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045935 Vd NA 0.4554 L/kg 1compartment NA NA Human Human +DTXSID8045933 TK.Half.Life NA 5.839 hours 1compartment NA NA Rat Human +DTXSID8045933 Css NA 0.05189 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045933 Css NA 0.3542 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045933 Css NA 0.05261 mg/L PBTK NA 50% Rat Human +DTXSID8045933 Css NA 0.2344 mg/L PBTK NA 95% Rat Human +DTXSID8045935 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045935 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045935 Vd NA 0.4679 L/kg 1compartment NA NA Human Human DTXSID8045935 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045935 TK.Half.Life NA 1.1 hours 1compartment NA NA Human Human -DTXSID8045935 Css NA 0.2256 mg/L 3compartmentss NA 50% Human Human -DTXSID8045935 Css NA 1.379 mg/L 3compartmentss NA 95% Human Human -DTXSID8045935 Css NA 0.1582 mg/L PBTK NA 50% Human Human -DTXSID8045935 Css NA 0.8729 mg/L PBTK NA 95% Human Human -DTXSID8045935 Clint NA 4.664 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045935 Fup NA 0.4105 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045935 Vd NA 0.4578 L/kg 1compartment NA NA Rat Human +DTXSID8045935 TK.Half.Life NA 0.7451 hours 1compartment NA NA Human Human +DTXSID8045935 Css NA 0.1248 mg/L 3compartmentss NA 50% Human Human +DTXSID8045935 Css NA 1.087 mg/L 3compartmentss NA 95% Human Human +DTXSID8045935 Css NA 0.08986 mg/L PBTK NA 50% Human Human +DTXSID8045935 Css NA 0.6913 mg/L PBTK NA 95% Human Human +DTXSID8045935 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045935 Fup 0.575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045935 Vd NA 0.4846 L/kg 1compartment NA NA Rat Human DTXSID8045935 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045935 TK.Half.Life NA 0.6139 hours 1compartment NA NA Rat Human -DTXSID8045935 Css NA 0.1104 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045935 Css NA 0.5371 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045935 Css NA 0.07415 mg/L PBTK NA 50% Rat Human -DTXSID8045935 Css NA 0.3209 mg/L PBTK NA 95% Rat Human -DTXSID8045937 Clint NA 2.618 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045937 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045937 Vd NA 0.2209 L/kg 1compartment NA NA Human Human -DTXSID8045937 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8045937 TK.Half.Life NA 16.68 hours 1compartment NA NA Human Human -DTXSID8045937 Css NA 13.81 mg/L 3compartmentss NA 50% Human Human -DTXSID8045937 Css NA 103 mg/L 3compartmentss NA 95% Human Human -DTXSID8045937 Css NA 8.197 mg/L PBTK NA 50% Human Human -DTXSID8045937 Css NA 59.02 mg/L PBTK NA 95% Human Human -DTXSID8045937 Clint NA 2.618 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045937 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045937 Vd NA 0.2159 L/kg 1compartment NA NA Rat Human -DTXSID8045937 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8045937 TK.Half.Life NA 9.513 hours 1compartment NA NA Rat Human -DTXSID8045937 Css NA 6.565 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045937 Css NA 41.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045937 Css NA 3.625 mg/L PBTK NA 50% Rat Human -DTXSID8045937 Css NA 22.41 mg/L PBTK NA 95% Rat Human -DTXSID8045939 Clint NA 7.897 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045939 Fup NA 0.4851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045939 Vd NA 0.5899 L/kg 1compartment NA NA Human Human +DTXSID8045935 TK.Half.Life NA 0.4141 hours 1compartment NA NA Rat Human +DTXSID8045935 Css NA 0.01427 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045935 Css NA 0.1052 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045935 Css NA 0.01032 mg/L PBTK NA 50% Rat Human +DTXSID8045935 Css NA 0.06388 mg/L PBTK NA 95% Rat Human +DTXSID8045937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045937 Fup 0.0571 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045937 Vd NA 0.3329 L/kg 1compartment NA NA Human Human +DTXSID8045937 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8045937 TK.Half.Life NA 1.309 hours 1compartment NA NA Human Human +DTXSID8045937 Css NA 0.2812 mg/L 3compartmentss NA 50% Human Human +DTXSID8045937 Css NA 2.5 mg/L 3compartmentss NA 95% Human Human +DTXSID8045937 Css NA 0.1741 mg/L PBTK NA 50% Human Human +DTXSID8045937 Css NA 1.503 mg/L PBTK NA 95% Human Human +DTXSID8045937 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045937 Fup 0.0571 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045937 Vd NA 0.3266 L/kg 1compartment NA NA Rat Human +DTXSID8045937 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8045937 TK.Half.Life NA 0.8005 hours 1compartment NA NA Rat Human +DTXSID8045937 Css NA 0.003029 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045937 Css NA 0.02309 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045937 Css NA 0.001765 mg/L PBTK NA 50% Rat Human +DTXSID8045937 Css NA 0.01295 mg/L PBTK NA 95% Rat Human +DTXSID8045939 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045939 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045939 Vd NA 0.6286 L/kg 1compartment NA NA Human Human DTXSID8045939 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045939 TK.Half.Life NA 0.9201 hours 1compartment NA NA Human Human -DTXSID8045939 Css NA 0.1157 mg/L 3compartmentss NA 50% Human Human -DTXSID8045939 Css NA 0.8533 mg/L 3compartmentss NA 95% Human Human -DTXSID8045939 Css NA 0.08693 mg/L PBTK NA 50% Human Human -DTXSID8045939 Css NA 0.5618 mg/L PBTK NA 95% Human Human -DTXSID8045939 Clint NA 7.897 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045939 Fup NA 0.4851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045939 Vd NA 0.5981 L/kg 1compartment NA NA Rat Human +DTXSID8045939 TK.Half.Life NA 0.9056 hours 1compartment NA NA Human Human +DTXSID8045939 Css NA 0.1037 mg/L 3compartmentss NA 50% Human Human +DTXSID8045939 Css NA 0.9356 mg/L 3compartmentss NA 95% Human Human +DTXSID8045939 Css NA 0.08136 mg/L PBTK NA 50% Human Human +DTXSID8045939 Css NA 0.6131 mg/L PBTK NA 95% Human Human +DTXSID8045939 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045939 Fup 0.596 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045939 Vd NA 0.6507 L/kg 1compartment NA NA Rat Human DTXSID8045939 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045939 TK.Half.Life NA 0.5074 hours 1compartment NA NA Rat Human -DTXSID8045939 Css NA 0.05808 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045939 Css NA 0.3361 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045939 Css NA 0.04208 mg/L PBTK NA 50% Rat Human -DTXSID8045939 Css NA 0.2044 mg/L PBTK NA 95% Rat Human -DTXSID8045983 Clint NA 0.07628 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045983 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045983 Vd NA 0.7715 L/kg 1compartment NA NA Human Human +DTXSID8045939 TK.Half.Life NA 0.5048 hours 1compartment NA NA Rat Human +DTXSID8045939 Css NA 0.01199 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045939 Css NA 0.09664 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045939 Css NA 0.009465 mg/L PBTK NA 50% Rat Human +DTXSID8045939 Css NA 0.05993 mg/L PBTK NA 95% Rat Human +DTXSID8045983 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045983 Fup 0.645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045983 Vd NA 0.6338 L/kg 1compartment NA NA Human Human DTXSID8045983 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045983 TK.Half.Life NA 4.44 hours 1compartment NA NA Human Human -DTXSID8045983 Css NA 0.7256 mg/L 3compartmentss NA 50% Human Human -DTXSID8045983 Css NA 4.963 mg/L 3compartmentss NA 95% Human Human -DTXSID8045983 Css NA 0.6085 mg/L PBTK NA 50% Human Human -DTXSID8045983 Css NA 3.184 mg/L PBTK NA 95% Human Human -DTXSID8045983 Clint NA 0.07628 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045983 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045983 Vd NA 0.8014 L/kg 1compartment NA NA Rat Human +DTXSID8045983 TK.Half.Life NA 6.365 hours 1compartment NA NA Human Human +DTXSID8045983 Css NA 1.144 mg/L 3compartmentss NA 50% Human Human +DTXSID8045983 Css NA 7.692 mg/L 3compartmentss NA 95% Human Human +DTXSID8045983 Css NA 0.9014 mg/L PBTK NA 50% Human Human +DTXSID8045983 Css NA 4.884 mg/L PBTK NA 95% Human Human +DTXSID8045983 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045983 Fup 0.645 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045983 Vd NA 0.657 L/kg 1compartment NA NA Rat Human DTXSID8045983 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045983 TK.Half.Life NA 1.666 hours 1compartment NA NA Rat Human -DTXSID8045983 Css NA 0.1981 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045983 Css NA 1.258 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045983 Css NA 0.162 mg/L PBTK NA 50% Rat Human -DTXSID8045983 Css NA 0.7546 mg/L PBTK NA 95% Rat Human -DTXSID8045985 Clint NA 23.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045985 Fup NA 0.1578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045985 Vd NA 0.4185 L/kg 1compartment NA NA Human Human +DTXSID8045983 TK.Half.Life NA 2.247 hours 1compartment NA NA Rat Human +DTXSID8045983 Css NA 0.06963 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045983 Css NA 0.4125 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045983 Css NA 0.05476 mg/L PBTK NA 50% Rat Human +DTXSID8045983 Css NA 0.2513 mg/L PBTK NA 95% Rat Human +DTXSID8045985 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045985 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045985 Vd NA 1.035 L/kg 1compartment NA NA Human Human DTXSID8045985 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045985 TK.Half.Life NA 0.7779 hours 1compartment NA NA Human Human -DTXSID8045985 Css NA 0.155 mg/L 3compartmentss NA 50% Human Human -DTXSID8045985 Css NA 1.14 mg/L 3compartmentss NA 95% Human Human -DTXSID8045985 Css NA 0.09946 mg/L PBTK NA 50% Human Human -DTXSID8045985 Css NA 0.7049 mg/L PBTK NA 95% Human Human -DTXSID8045985 Clint NA 23.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045985 Fup NA 0.1578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045985 Vd NA 0.3907 L/kg 1compartment NA NA Rat Human +DTXSID8045985 TK.Half.Life NA 3.342 hours 1compartment NA NA Human Human +DTXSID8045985 Css NA 0.303 mg/L 3compartmentss NA 50% Human Human +DTXSID8045985 Css NA 1.798 mg/L 3compartmentss NA 95% Human Human +DTXSID8045985 Css NA 0.2152 mg/L PBTK NA 50% Human Human +DTXSID8045985 Css NA 1.196 mg/L PBTK NA 95% Human Human +DTXSID8045985 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045985 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045985 Vd NA 0.8495 L/kg 1compartment NA NA Rat Human DTXSID8045985 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045985 TK.Half.Life NA 0.408 hours 1compartment NA NA Rat Human -DTXSID8045985 Css NA 0.08638 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045985 Css NA 0.5204 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045985 Css NA 0.05202 mg/L PBTK NA 50% Rat Human -DTXSID8045985 Css NA 0.2985 mg/L PBTK NA 95% Rat Human +DTXSID8045985 TK.Half.Life NA 1.495 hours 1compartment NA NA Rat Human +DTXSID8045985 Css NA 0.03614 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045985 Css NA 0.1545 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045985 Css NA 0.02534 mg/L PBTK NA 50% Rat Human +DTXSID8045985 Css NA 0.09974 mg/L PBTK NA 95% Rat Human DTXSID8045987 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8045987 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045987 Vd NA 0.4839 L/kg 1compartment NA NA Human Human +DTXSID8045987 Vd NA 0.4823 L/kg 1compartment NA NA Human Human DTXSID8045987 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045987 TK.Half.Life NA 3.132 hours 1compartment NA NA Human Human -DTXSID8045987 Css NA 0.9358 mg/L 3compartmentss NA 50% Human Human -DTXSID8045987 Css NA 5.738 mg/L 3compartmentss NA 95% Human Human -DTXSID8045987 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID8045987 Css NA 3.627 mg/L PBTK NA 95% Human Human +DTXSID8045987 TK.Half.Life NA 3.121 hours 1compartment NA NA Human Human +DTXSID8045987 Css NA 0.7905 mg/L 3compartmentss NA 50% Human Human +DTXSID8045987 Css NA 5.23 mg/L 3compartmentss NA 95% Human Human +DTXSID8045987 Css NA 0.5892 mg/L PBTK NA 50% Human Human +DTXSID8045987 Css NA 3.3 mg/L PBTK NA 95% Human Human DTXSID8045987 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8045987 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045987 Vd NA 0.514 L/kg 1compartment NA NA Rat Human +DTXSID8045987 Vd NA 0.5124 L/kg 1compartment NA NA Rat Human DTXSID8045987 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045987 TK.Half.Life NA 1.133 hours 1compartment NA NA Rat Human -DTXSID8045987 Css NA 0.238 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045987 Css NA 1.381 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045987 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID8045987 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID8045989 Clint NA 5.285 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045989 Fup NA 0.2307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8045989 Vd NA 3.289 L/kg 1compartment NA NA Human Human +DTXSID8045987 TK.Half.Life NA 1.13 hours 1compartment NA NA Rat Human +DTXSID8045987 Css NA 0.01462 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045987 Css NA 0.1054 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045987 Css NA 0.01051 mg/L PBTK NA 50% Rat Human +DTXSID8045987 Css NA 0.06515 mg/L PBTK NA 95% Rat Human +DTXSID8045989 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045989 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8045989 Vd NA 1.286 L/kg 1compartment NA NA Human Human DTXSID8045989 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8045989 TK.Half.Life NA 13 hours 1compartment NA NA Human Human -DTXSID8045989 Css NA 0.3223 mg/L 3compartmentss NA 50% Human Human -DTXSID8045989 Css NA 1.881 mg/L 3compartmentss NA 95% Human Human -DTXSID8045989 Css NA 0.3067 mg/L PBTK NA 50% Human Human -DTXSID8045989 Css NA 1.564 mg/L PBTK NA 95% Human Human -DTXSID8045989 Clint NA 5.285 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045989 Fup NA 0.2307 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8045989 Vd NA 3.019 L/kg 1compartment NA NA Rat Human +DTXSID8045989 TK.Half.Life NA 2.589 hours 1compartment NA NA Human Human +DTXSID8045989 Css NA 0.1512 mg/L 3compartmentss NA 50% Human Human +DTXSID8045989 Css NA 1.07 mg/L 3compartmentss NA 95% Human Human +DTXSID8045989 Css NA 0.1246 mg/L PBTK NA 50% Human Human +DTXSID8045989 Css NA 0.7459 mg/L PBTK NA 95% Human Human +DTXSID8045989 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045989 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8045989 Vd NA 1.294 L/kg 1compartment NA NA Rat Human DTXSID8045989 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8045989 TK.Half.Life NA 5.484 hours 1compartment NA NA Rat Human -DTXSID8045989 Css NA 0.16 mg/L 3compartmentss NA 50% Rat Human -DTXSID8045989 Css NA 0.7252 mg/L 3compartmentss NA 95% Rat Human -DTXSID8045989 Css NA 0.1521 mg/L PBTK NA 50% Rat Human -DTXSID8045989 Css NA 0.5666 mg/L PBTK NA 95% Rat Human -DTXSID8046030 Clint NA 0.0404 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046030 Fup NA 0.6329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046030 Vd NA 0.4636 L/kg 1compartment NA NA Human Human +DTXSID8045989 TK.Half.Life NA 1.479 hours 1compartment NA NA Rat Human +DTXSID8045989 Css NA 0.01724 mg/L 3compartmentss NA 50% Rat Human +DTXSID8045989 Css NA 0.09247 mg/L 3compartmentss NA 95% Rat Human +DTXSID8045989 Css NA 0.01441 mg/L PBTK NA 50% Rat Human +DTXSID8045989 Css NA 0.0627 mg/L PBTK NA 95% Rat Human +DTXSID8046030 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046030 Fup 0.67 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046030 Vd NA 0.4226 L/kg 1compartment NA NA Human Human DTXSID8046030 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046030 TK.Half.Life NA 4.432 hours 1compartment NA NA Human Human -DTXSID8046030 Css NA 1.17 mg/L 3compartmentss NA 50% Human Human -DTXSID8046030 Css NA 7.226 mg/L 3compartmentss NA 95% Human Human -DTXSID8046030 Css NA 0.8689 mg/L PBTK NA 50% Human Human -DTXSID8046030 Css NA 4.496 mg/L PBTK NA 95% Human Human -DTXSID8046030 Clint NA 0.0404 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046030 Fup NA 0.6329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046030 Vd NA 0.4777 L/kg 1compartment NA NA Rat Human +DTXSID8046030 TK.Half.Life NA 4.08 hours 1compartment NA NA Human Human +DTXSID8046030 Css NA 0.6772 mg/L 3compartmentss NA 50% Human Human +DTXSID8046030 Css NA 4.308 mg/L 3compartmentss NA 95% Human Human +DTXSID8046030 Css NA 0.494 mg/L PBTK NA 50% Human Human +DTXSID8046030 Css NA 2.634 mg/L PBTK NA 95% Human Human +DTXSID8046030 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046030 Fup 0.67 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046030 Vd NA 0.4439 L/kg 1compartment NA NA Rat Human DTXSID8046030 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046030 TK.Half.Life NA 1.61 hours 1compartment NA NA Rat Human -DTXSID8046030 Css NA 0.3216 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046030 Css NA 1.985 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046030 Css NA 0.2284 mg/L PBTK NA 50% Rat Human -DTXSID8046030 Css NA 1.14 mg/L PBTK NA 95% Rat Human +DTXSID8046030 TK.Half.Life NA 1.461 hours 1compartment NA NA Rat Human +DTXSID8046030 Css NA 0.003564 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046030 Css NA 0.02445 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046030 Css NA 0.002504 mg/L PBTK NA 50% Rat Human +DTXSID8046030 Css NA 0.01435 mg/L PBTK NA 95% Rat Human DTXSID8046034 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8046034 Fup NA 0.7167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046034 Vd NA 0.7363 L/kg 1compartment NA NA Human Human +DTXSID8046034 Vd NA 0.573 L/kg 1compartment NA NA Human Human DTXSID8046034 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046034 TK.Half.Life NA 6.646 hours 1compartment NA NA Human Human -DTXSID8046034 Css NA 1.061 mg/L 3compartmentss NA 50% Human Human -DTXSID8046034 Css NA 6.911 mg/L 3compartmentss NA 95% Human Human -DTXSID8046034 Css NA 0.866 mg/L PBTK NA 50% Human Human -DTXSID8046034 Css NA 4.41 mg/L PBTK NA 95% Human Human +DTXSID8046034 TK.Half.Life NA 5.173 hours 1compartment NA NA Human Human +DTXSID8046034 Css NA 0.945 mg/L 3compartmentss NA 50% Human Human +DTXSID8046034 Css NA 5.908 mg/L 3compartmentss NA 95% Human Human +DTXSID8046034 Css NA 0.744 mg/L PBTK NA 50% Human Human +DTXSID8046034 Css NA 3.781 mg/L PBTK NA 95% Human Human DTXSID8046034 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8046034 Fup NA 0.7167 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046034 Vd NA 0.7868 L/kg 1compartment NA NA Rat Human +DTXSID8046034 Vd NA 0.614 L/kg 1compartment NA NA Rat Human DTXSID8046034 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046034 TK.Half.Life NA 2.421 hours 1compartment NA NA Rat Human -DTXSID8046034 Css NA 0.2784 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046034 Css NA 1.769 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046034 Css NA 0.218 mg/L PBTK NA 50% Rat Human -DTXSID8046034 Css NA 1.045 mg/L PBTK NA 95% Rat Human -DTXSID8046036 Clint NA 42.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046036 Fup NA 0.0321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046036 Vd NA 2.123 L/kg 1compartment NA NA Human Human -DTXSID8046036 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046036 TK.Half.Life NA 9.332 hours 1compartment NA NA Human Human -DTXSID8046036 Css NA 0.5742 mg/L 3compartmentss NA 50% Human Human -DTXSID8046036 Css NA 4.689 mg/L 3compartmentss NA 95% Human Human -DTXSID8046036 Css NA 0.3762 mg/L PBTK NA 50% Human Human -DTXSID8046036 Css NA 2.861 mg/L PBTK NA 95% Human Human -DTXSID8046036 Clint NA 42.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046036 Fup NA 0.0321 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046036 Vd NA 1.584 L/kg 1compartment NA NA Rat Human +DTXSID8046034 TK.Half.Life NA 1.889 hours 1compartment NA NA Rat Human +DTXSID8046034 Css NA 0.01833 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046034 Css NA 0.1494 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046034 Css NA 0.01368 mg/L PBTK NA 50% Rat Human +DTXSID8046034 Css NA 0.09272 mg/L PBTK NA 95% Rat Human +DTXSID8046036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046036 Fup 0.0224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046036 Vd NA 1.975 L/kg 1compartment NA NA Human Human +DTXSID8046036 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046036 TK.Half.Life NA 18.56 hours 1compartment NA NA Human Human +DTXSID8046036 Css NA 1.398 mg/L 3compartmentss NA 50% Human Human +DTXSID8046036 Css NA 11.72 mg/L 3compartmentss NA 95% Human Human +DTXSID8046036 Css NA 0.8948 mg/L PBTK NA 50% Human Human +DTXSID8046036 Css NA 7.208 mg/L PBTK NA 95% Human Human +DTXSID8046036 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046036 Fup 0.0224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046036 Vd NA 1.469 L/kg 1compartment NA NA Rat Human DTXSID8046036 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046036 TK.Half.Life NA 2.899 hours 1compartment NA NA Rat Human -DTXSID8046036 Css NA 0.3224 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046036 Css NA 2.111 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046036 Css NA 0.199 mg/L PBTK NA 50% Rat Human -DTXSID8046036 Css NA 1.217 mg/L PBTK NA 95% Rat Human -DTXSID8046038 Clint NA 15.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046038 Fup NA 0.3098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046038 Vd NA 0.8101 L/kg 1compartment NA NA Human Human -DTXSID8046038 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046038 TK.Half.Life NA 1.166 hours 1compartment NA NA Human Human -DTXSID8046038 Css NA 0.08876 mg/L 3compartmentss NA 50% Human Human -DTXSID8046038 Css NA 0.6842 mg/L 3compartmentss NA 95% Human Human -DTXSID8046038 Css NA 0.06606 mg/L PBTK NA 50% Human Human -DTXSID8046038 Css NA 0.4588 mg/L PBTK NA 95% Human Human -DTXSID8046038 Clint NA 15.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046038 Fup NA 0.3098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046038 Vd NA 0.8255 L/kg 1compartment NA NA Rat Human +DTXSID8046036 TK.Half.Life NA 6.038 hours 1compartment NA NA Rat Human +DTXSID8046036 Css NA 0.1774 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046036 Css NA 1.224 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046036 Css NA 0.1117 mg/L PBTK NA 50% Rat Human +DTXSID8046036 Css NA 0.7354 mg/L PBTK NA 95% Rat Human +DTXSID8046038 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046038 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046038 Vd NA 1.007 L/kg 1compartment NA NA Human Human +DTXSID8046038 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046038 TK.Half.Life NA 14.51 hours 1compartment NA NA Human Human +DTXSID8046038 Css NA 1.422 mg/L 3compartmentss NA 50% Human Human +DTXSID8046038 Css NA 6.887 mg/L 3compartmentss NA 95% Human Human +DTXSID8046038 Css NA 1.161 mg/L PBTK NA 50% Human Human +DTXSID8046038 Css NA 4.509 mg/L PBTK NA 95% Human Human +DTXSID8046038 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046038 Fup 0.449 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046038 Vd NA 1.03 L/kg 1compartment NA NA Rat Human DTXSID8046038 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046038 TK.Half.Life NA 0.6502 hours 1compartment NA NA Rat Human -DTXSID8046038 Css NA 0.04741 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046038 Css NA 0.2754 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046038 Css NA 0.03395 mg/L PBTK NA 50% Rat Human -DTXSID8046038 Css NA 0.1744 mg/L PBTK NA 95% Rat Human -DTXSID8046084 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046084 Fup NA 0.4764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046084 Vd NA 0.3665 L/kg 1compartment NA NA Human Human +DTXSID8046038 TK.Half.Life NA 5.056 hours 1compartment NA NA Rat Human +DTXSID8046038 Css NA 0.09052 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046038 Css NA 0.389 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046038 Css NA 0.07366 mg/L PBTK NA 50% Rat Human +DTXSID8046038 Css NA 0.247 mg/L PBTK NA 95% Rat Human +DTXSID8046084 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046084 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046084 Vd NA 0.298 L/kg 1compartment NA NA Human Human DTXSID8046084 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046084 TK.Half.Life NA 4.976 hours 1compartment NA NA Human Human -DTXSID8046084 Css NA 1.656 mg/L 3compartmentss NA 50% Human Human -DTXSID8046084 Css NA 7.544 mg/L 3compartmentss NA 95% Human Human -DTXSID8046084 Css NA 1.149 mg/L PBTK NA 50% Human Human -DTXSID8046084 Css NA 4.644 mg/L PBTK NA 95% Human Human -DTXSID8046084 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046084 Fup NA 0.4764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046084 Vd NA 0.3782 L/kg 1compartment NA NA Rat Human +DTXSID8046084 TK.Half.Life NA 6.583 hours 1compartment NA NA Human Human +DTXSID8046084 Css NA 1.493 mg/L 3compartmentss NA 50% Human Human +DTXSID8046084 Css NA 5.934 mg/L 3compartmentss NA 95% Human Human +DTXSID8046084 Css NA 0.9718 mg/L PBTK NA 50% Human Human +DTXSID8046084 Css NA 3.619 mg/L PBTK NA 95% Human Human +DTXSID8046084 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046084 Fup 0.293 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046084 Vd NA 0.3056 L/kg 1compartment NA NA Rat Human DTXSID8046084 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046084 TK.Half.Life NA 1.75 hours 1compartment NA NA Rat Human -DTXSID8046084 Css NA 0.452 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046084 Css NA 1.843 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046084 Css NA 0.2973 mg/L PBTK NA 50% Rat Human -DTXSID8046084 Css NA 1.056 mg/L PBTK NA 95% Rat Human -DTXSID8046086 Clint NA 8.812 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046086 Fup NA 0.2111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046086 Vd NA 1.399 L/kg 1compartment NA NA Human Human +DTXSID8046084 TK.Half.Life NA 2.3 hours 1compartment NA NA Rat Human +DTXSID8046084 Css NA 0.008054 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046084 Css NA 0.03353 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046084 Css NA 0.004979 mg/L PBTK NA 50% Rat Human +DTXSID8046084 Css NA 0.01938 mg/L PBTK NA 95% Rat Human +DTXSID8046086 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046086 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046086 Vd NA 0.6422 L/kg 1compartment NA NA Human Human DTXSID8046086 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046086 TK.Half.Life NA 4.141 hours 1compartment NA NA Human Human -DTXSID8046086 Css NA 0.2742 mg/L 3compartmentss NA 50% Human Human -DTXSID8046086 Css NA 1.669 mg/L 3compartmentss NA 95% Human Human -DTXSID8046086 Css NA 0.1978 mg/L PBTK NA 50% Human Human -DTXSID8046086 Css NA 1.135 mg/L PBTK NA 95% Human Human -DTXSID8046086 Clint NA 8.812 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046086 Fup NA 0.2111 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046086 Vd NA 1.114 L/kg 1compartment NA NA Rat Human +DTXSID8046086 TK.Half.Life NA 1.535 hours 1compartment NA NA Human Human +DTXSID8046086 Css NA 0.2047 mg/L 3compartmentss NA 50% Human Human +DTXSID8046086 Css NA 1.312 mg/L 3compartmentss NA 95% Human Human +DTXSID8046086 Css NA 0.1476 mg/L PBTK NA 50% Human Human +DTXSID8046086 Css NA 0.8525 mg/L PBTK NA 95% Human Human +DTXSID8046086 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046086 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046086 Vd NA 0.6094 L/kg 1compartment NA NA Rat Human DTXSID8046086 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046086 TK.Half.Life NA 1.701 hours 1compartment NA NA Rat Human -DTXSID8046086 Css NA 0.1458 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046086 Css NA 0.6416 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046086 Css NA 0.1003 mg/L PBTK NA 50% Rat Human -DTXSID8046086 Css NA 0.4003 mg/L PBTK NA 95% Rat Human -DTXSID8046088 Clint NA 36.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046088 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046088 Vd NA 2.435 L/kg 1compartment NA NA Human Human -DTXSID8046088 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8046088 TK.Half.Life NA 19.62 hours 1compartment NA NA Human Human -DTXSID8046088 Css NA 1.139 mg/L 3compartmentss NA 50% Human Human -DTXSID8046088 Css NA 8.633 mg/L 3compartmentss NA 95% Human Human -DTXSID8046088 Css NA 0.7544 mg/L PBTK NA 50% Human Human -DTXSID8046088 Css NA 5.492 mg/L PBTK NA 95% Human Human -DTXSID8046088 Clint NA 36.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046088 Fup NA 0.0162 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046088 Vd NA 1.847 L/kg 1compartment NA NA Rat Human -DTXSID8046088 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8046088 TK.Half.Life NA 5.506 hours 1compartment NA NA Rat Human -DTXSID8046088 Css NA 0.6232 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046088 Css NA 4.059 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046088 Css NA 0.3918 mg/L PBTK NA 50% Rat Human -DTXSID8046088 Css NA 2.444 mg/L PBTK NA 95% Rat Human -DTXSID8046113 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046113 Fup NA 0.3926 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046113 Vd NA 1.097 L/kg 1compartment NA NA Human Human +DTXSID8046086 TK.Half.Life NA 0.8219 hours 1compartment NA NA Rat Human +DTXSID8046086 Css NA 0.02388 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046086 Css NA 0.1142 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046086 Css NA 0.0171 mg/L PBTK NA 50% Rat Human +DTXSID8046086 Css NA 0.07244 mg/L PBTK NA 95% Rat Human +DTXSID8046088 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046088 Fup 0.0444 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046088 Vd NA 1.823 L/kg 1compartment NA NA Human Human +DTXSID8046088 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8046088 TK.Half.Life NA 10.16 hours 1compartment NA NA Human Human +DTXSID8046088 Css NA 0.7554 mg/L 3compartmentss NA 50% Human Human +DTXSID8046088 Css NA 5.578 mg/L 3compartmentss NA 95% Human Human +DTXSID8046088 Css NA 0.4878 mg/L PBTK NA 50% Human Human +DTXSID8046088 Css NA 3.498 mg/L PBTK NA 95% Human Human +DTXSID8046088 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046088 Fup 0.0444 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046088 Vd NA 1.364 L/kg 1compartment NA NA Rat Human +DTXSID8046088 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8046088 TK.Half.Life NA 3.526 hours 1compartment NA NA Rat Human +DTXSID8046088 Css NA 0.09642 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046088 Css NA 0.5784 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046088 Css NA 0.0611 mg/L PBTK NA 50% Rat Human +DTXSID8046088 Css NA 0.353 mg/L PBTK NA 95% Rat Human +DTXSID8046113 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046113 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046113 Vd NA 0.8427 L/kg 1compartment NA NA Human Human DTXSID8046113 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046113 TK.Half.Life NA 2.288 hours 1compartment NA NA Human Human -DTXSID8046113 Css NA 0.169 mg/L 3compartmentss NA 50% Human Human -DTXSID8046113 Css NA 1.077 mg/L 3compartmentss NA 95% Human Human -DTXSID8046113 Css NA 0.1315 mg/L PBTK NA 50% Human Human -DTXSID8046113 Css NA 0.7617 mg/L PBTK NA 95% Human Human -DTXSID8046113 Clint NA 6.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046113 Fup NA 0.3926 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046113 Vd NA 0.954 L/kg 1compartment NA NA Rat Human +DTXSID8046113 TK.Half.Life NA 0.9314 hours 1compartment NA NA Human Human +DTXSID8046113 Css NA 0.04751 mg/L 3compartmentss NA 50% Human Human +DTXSID8046113 Css NA 0.4002 mg/L 3compartmentss NA 95% Human Human +DTXSID8046113 Css NA 0.03668 mg/L PBTK NA 50% Human Human +DTXSID8046113 Css NA 0.2779 mg/L PBTK NA 95% Human Human +DTXSID8046113 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046113 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046113 Vd NA 0.7754 L/kg 1compartment NA NA Rat Human DTXSID8046113 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046113 TK.Half.Life NA 1.067 hours 1compartment NA NA Rat Human -DTXSID8046113 Css NA 0.08474 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046113 Css NA 0.4292 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046113 Css NA 0.06389 mg/L PBTK NA 50% Rat Human -DTXSID8046113 Css NA 0.2714 mg/L PBTK NA 95% Rat Human -DTXSID8046117 Clint NA 1.105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046117 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046117 Vd NA 2.814 L/kg 1compartment NA NA Human Human -DTXSID8046117 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8046117 TK.Half.Life NA 20.9 hours 1compartment NA NA Human Human -DTXSID8046117 Css NA 0.7036 mg/L 3compartmentss NA 50% Human Human -DTXSID8046117 Css NA 3.996 mg/L 3compartmentss NA 95% Human Human -DTXSID8046117 Css NA 0.6195 mg/L PBTK NA 50% Human Human -DTXSID8046117 Css NA 2.837 mg/L PBTK NA 95% Human Human -DTXSID8046117 Clint NA 1.105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046117 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046117 Vd NA 2.219 L/kg 1compartment NA NA Rat Human +DTXSID8046113 TK.Half.Life NA 0.4384 hours 1compartment NA NA Rat Human +DTXSID8046113 Css NA 0.005876 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046113 Css NA 0.0382 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046113 Css NA 0.004515 mg/L PBTK NA 50% Rat Human +DTXSID8046113 Css NA 0.02606 mg/L PBTK NA 95% Rat Human +DTXSID8046117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046117 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046117 Vd NA 0.3154 L/kg 1compartment NA NA Human Human +DTXSID8046117 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8046117 TK.Half.Life NA 0.4909 hours 1compartment NA NA Human Human +DTXSID8046117 Css NA 0.09625 mg/L 3compartmentss NA 50% Human Human +DTXSID8046117 Css NA 0.6667 mg/L 3compartmentss NA 95% Human Human +DTXSID8046117 Css NA 0.06236 mg/L PBTK NA 50% Human Human +DTXSID8046117 Css NA 0.4149 mg/L PBTK NA 95% Human Human +DTXSID8046117 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046117 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046117 Vd NA 0.3289 L/kg 1compartment NA NA Rat Human DTXSID8046117 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046117 TK.Half.Life NA 3.974 hours 1compartment NA NA Rat Human -DTXSID8046117 Css NA 0.2801 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046117 Css NA 1.177 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046117 Css NA 0.2412 mg/L PBTK NA 50% Rat Human -DTXSID8046117 Css NA 0.7717 mg/L PBTK NA 95% Rat Human -DTXSID8046119 Clint NA 10.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046119 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046119 Vd NA 7.549 L/kg 1compartment NA NA Human Human +DTXSID8046117 TK.Half.Life NA 0.2773 hours 1compartment NA NA Rat Human +DTXSID8046117 Css NA 0.01206 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046117 Css NA 0.06692 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046117 Css NA 0.007668 mg/L PBTK NA 50% Rat Human +DTXSID8046117 Css NA 0.04005 mg/L PBTK NA 95% Rat Human +DTXSID8046119 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046119 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046119 Vd NA 3.568 L/kg 1compartment NA NA Human Human DTXSID8046119 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046119 TK.Half.Life NA 4.085 hours 1compartment NA NA Human Human -DTXSID8046119 Css NA 0.01836 mg/L 3compartmentss NA 50% Human Human -DTXSID8046119 Css NA 0.2997 mg/L 3compartmentss NA 95% Human Human -DTXSID8046119 Css NA 0.03626 mg/L PBTK NA 50% Human Human -DTXSID8046119 Css NA 0.3641 mg/L PBTK NA 95% Human Human -DTXSID8046119 Clint NA 10.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046119 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046119 Vd NA 7.779 L/kg 1compartment NA NA Rat Human +DTXSID8046119 TK.Half.Life NA 5.475 hours 1compartment NA NA Human Human +DTXSID8046119 Css NA 0.1017 mg/L 3compartmentss NA 50% Human Human +DTXSID8046119 Css NA 0.8961 mg/L 3compartmentss NA 95% Human Human +DTXSID8046119 Css NA 0.09556 mg/L PBTK NA 50% Human Human +DTXSID8046119 Css NA 0.7131 mg/L PBTK NA 95% Human Human +DTXSID8046119 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046119 Fup 0.115 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046119 Vd NA 3.317 L/kg 1compartment NA NA Rat Human DTXSID8046119 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046119 TK.Half.Life NA 2.245 hours 1compartment NA NA Rat Human -DTXSID8046119 Css NA 0.008472 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046119 Css NA 0.107 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046119 Css NA 0.01782 mg/L PBTK NA 50% Rat Human -DTXSID8046119 Css NA 0.1188 mg/L PBTK NA 95% Rat Human -DTXSID8046161 Clint NA 1.736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046161 Fup NA 0.1694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046161 Vd NA 0.3214 L/kg 1compartment NA NA Human Human +DTXSID8046119 TK.Half.Life NA 2.423 hours 1compartment NA NA Rat Human +DTXSID8046119 Css NA 0.01294 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046119 Css NA 0.09234 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046119 Css NA 0.01231 mg/L PBTK NA 50% Rat Human +DTXSID8046119 Css NA 0.07445 mg/L PBTK NA 95% Rat Human +DTXSID8046161 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046161 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046161 Vd NA 0.3599 L/kg 1compartment NA NA Human Human DTXSID8046161 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046161 TK.Half.Life NA 3.288 hours 1compartment NA NA Human Human -DTXSID8046161 Css NA 1.266 mg/L 3compartmentss NA 50% Human Human -DTXSID8046161 Css NA 5.616 mg/L 3compartmentss NA 95% Human Human -DTXSID8046161 Css NA 0.8247 mg/L PBTK NA 50% Human Human -DTXSID8046161 Css NA 3.414 mg/L PBTK NA 95% Human Human -DTXSID8046161 Clint NA 1.736 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046161 Fup NA 0.1694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046161 Vd NA 0.3226 L/kg 1compartment NA NA Rat Human +DTXSID8046161 TK.Half.Life NA 1.174 hours 1compartment NA NA Human Human +DTXSID8046161 Css NA 0.3226 mg/L 3compartmentss NA 50% Human Human +DTXSID8046161 Css NA 1.851 mg/L 3compartmentss NA 95% Human Human +DTXSID8046161 Css NA 0.2138 mg/L PBTK NA 50% Human Human +DTXSID8046161 Css NA 1.17 mg/L PBTK NA 95% Human Human +DTXSID8046161 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046161 Fup 0.219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046161 Vd NA 0.362 L/kg 1compartment NA NA Rat Human DTXSID8046161 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046161 TK.Half.Life NA 1.78 hours 1compartment NA NA Rat Human -DTXSID8046161 Css NA 0.5734 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046161 Css NA 1.892 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046161 Css NA 0.3486 mg/L PBTK NA 50% Rat Human -DTXSID8046161 Css NA 1.077 mg/L PBTK NA 95% Rat Human -DTXSID8046163 Clint NA 12.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046163 Fup NA 0.1595 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046163 Vd NA 0.5028 L/kg 1compartment NA NA Human Human +DTXSID8046161 TK.Half.Life NA 0.6904 hours 1compartment NA NA Rat Human +DTXSID8046161 Css NA 0.03834 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046161 Css NA 0.1664 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046161 Css NA 0.02505 mg/L PBTK NA 50% Rat Human +DTXSID8046161 Css NA 0.1003 mg/L PBTK NA 95% Rat Human +DTXSID8046163 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046163 Fup 0.525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046163 Vd NA 0.8783 L/kg 1compartment NA NA Human Human DTXSID8046163 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046163 TK.Half.Life NA 1.315 hours 1compartment NA NA Human Human -DTXSID8046163 Css NA 0.2706 mg/L 3compartmentss NA 50% Human Human -DTXSID8046163 Css NA 1.908 mg/L 3compartmentss NA 95% Human Human -DTXSID8046163 Css NA 0.1762 mg/L PBTK NA 50% Human Human -DTXSID8046163 Css NA 1.175 mg/L PBTK NA 95% Human Human -DTXSID8046163 Clint NA 12.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046163 Fup NA 0.1595 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046163 Vd NA 0.461 L/kg 1compartment NA NA Rat Human +DTXSID8046163 TK.Half.Life NA 1.449 hours 1compartment NA NA Human Human +DTXSID8046163 Css NA 0.1211 mg/L 3compartmentss NA 50% Human Human +DTXSID8046163 Css NA 0.9768 mg/L 3compartmentss NA 95% Human Human +DTXSID8046163 Css NA 0.09648 mg/L PBTK NA 50% Human Human +DTXSID8046163 Css NA 0.6695 mg/L PBTK NA 95% Human Human +DTXSID8046163 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046163 Fup 0.525 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046163 Vd NA 0.8298 L/kg 1compartment NA NA Rat Human DTXSID8046163 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046163 TK.Half.Life NA 0.7045 hours 1compartment NA NA Rat Human -DTXSID8046163 Css NA 0.1474 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046163 Css NA 0.7554 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046163 Css NA 0.09088 mg/L PBTK NA 50% Rat Human -DTXSID8046163 Css NA 0.4344 mg/L PBTK NA 95% Rat Human -DTXSID8046165 Clint NA 0.4848 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046165 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046165 Vd NA 1.989 L/kg 1compartment NA NA Human Human +DTXSID8046163 TK.Half.Life NA 0.7412 hours 1compartment NA NA Rat Human +DTXSID8046163 Css NA 0.01393 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046163 Css NA 0.09473 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046163 Css NA 0.01118 mg/L PBTK NA 50% Rat Human +DTXSID8046163 Css NA 0.06031 mg/L PBTK NA 95% Rat Human +DTXSID8046165 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046165 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046165 Vd NA 1.052 L/kg 1compartment NA NA Human Human DTXSID8046165 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046165 TK.Half.Life NA 9.587 hours 1compartment NA NA Human Human -DTXSID8046165 Css NA 0.414 mg/L 3compartmentss NA 50% Human Human -DTXSID8046165 Css NA 2.977 mg/L 3compartmentss NA 95% Human Human -DTXSID8046165 Css NA 0.4182 mg/L PBTK NA 50% Human Human -DTXSID8046165 Css NA 2.096 mg/L PBTK NA 95% Human Human -DTXSID8046165 Clint NA 0.4848 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046165 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046165 Vd NA 1.718 L/kg 1compartment NA NA Rat Human +DTXSID8046165 TK.Half.Life NA 2.66 hours 1compartment NA NA Human Human +DTXSID8046165 Css NA 0.2148 mg/L 3compartmentss NA 50% Human Human +DTXSID8046165 Css NA 1.314 mg/L 3compartmentss NA 95% Human Human +DTXSID8046165 Css NA 0.1609 mg/L PBTK NA 50% Human Human +DTXSID8046165 Css NA 0.8858 mg/L PBTK NA 95% Human Human +DTXSID8046165 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046165 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046165 Vd NA 0.8999 L/kg 1compartment NA NA Rat Human DTXSID8046165 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046165 TK.Half.Life NA 2.942 hours 1compartment NA NA Rat Human -DTXSID8046165 Css NA 0.1376 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046165 Css NA 0.9035 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046165 Css NA 0.1387 mg/L PBTK NA 50% Rat Human -DTXSID8046165 Css NA 0.5883 mg/L PBTK NA 95% Rat Human +DTXSID8046165 TK.Half.Life NA 1.236 hours 1compartment NA NA Rat Human +DTXSID8046165 Css NA 0.02502 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046165 Css NA 0.1234 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046165 Css NA 0.01876 mg/L PBTK NA 50% Rat Human +DTXSID8046165 Css NA 0.08103 mg/L PBTK NA 95% Rat Human +DTXSID8046167 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046167 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046167 Vd NA 5.47 L/kg 1compartment NA NA Human Human +DTXSID8046167 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8046167 TK.Half.Life NA 2.677 hours 1compartment NA NA Human Human +DTXSID8046167 Css NA 0.008302 mg/L 3compartmentss NA 50% Human Human +DTXSID8046167 Css NA 0.081 mg/L 3compartmentss NA 95% Human Human +DTXSID8046167 Css NA 0.01362 mg/L PBTK NA 50% Human Human +DTXSID8046167 Css NA 0.09895 mg/L PBTK NA 95% Human Human +DTXSID8046167 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046167 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046167 Vd NA 5.349 L/kg 1compartment NA NA Rat Human +DTXSID8046167 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8046167 TK.Half.Life NA 1.25 hours 1compartment NA NA Rat Human +DTXSID8046167 Css NA 0.001019 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046167 Css NA 0.007854 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046167 Css NA 0.0018 mg/L PBTK NA 50% Rat Human +DTXSID8046167 Css NA 0.01056 mg/L PBTK NA 95% Rat Human DTXSID8046169 Clint NA 3814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8046169 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046169 Vd NA 388.1 L/kg 1compartment NA NA Human Human -DTXSID8046169 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID8046169 TK.Half.Life NA 70.44 hours 1compartment NA NA Human Human -DTXSID8046169 Css NA 0.0002556 mg/L 3compartmentss NA 50% Human Human -DTXSID8046169 Css NA 0.001595 mg/L 3compartmentss NA 95% Human Human -DTXSID8046169 Css NA 0.01433 mg/L PBTK NA 50% Human Human -DTXSID8046169 Css NA 0.08121 mg/L PBTK NA 95% Human Human +DTXSID8046169 Vd NA 6.953 L/kg 1compartment NA NA Human Human +DTXSID8046169 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8046169 TK.Half.Life NA 5.295 hours 1compartment NA NA Human Human +DTXSID8046169 Css NA 0.009755 mg/L 3compartmentss NA 50% Human Human +DTXSID8046169 Css NA 0.07474 mg/L 3compartmentss NA 95% Human Human +DTXSID8046169 Css NA 0.009168 mg/L PBTK NA 50% Human Human +DTXSID8046169 Css NA 0.06907 mg/L PBTK NA 95% Human Human DTXSID8046169 Clint NA 3814 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8046169 Fup NA 0.0036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046169 Vd NA 348.7 L/kg 1compartment NA NA Rat Human -DTXSID8046169 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID8046169 TK.Half.Life NA 12.65 hours 1compartment NA NA Rat Human -DTXSID8046169 Css NA 0.0001306 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046169 Css NA 0.0005454 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046169 Css NA 0.007808 mg/L PBTK NA 50% Rat Human -DTXSID8046169 Css NA 0.03287 mg/L PBTK NA 95% Rat Human -DTXSID8046240 Clint NA 7.439 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046240 Fup NA 0.0329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046240 Vd NA 0.2734 L/kg 1compartment NA NA Human Human +DTXSID8046169 Vd NA 5.386 L/kg 1compartment NA NA Rat Human +DTXSID8046169 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8046169 TK.Half.Life NA 1.566 hours 1compartment NA NA Rat Human +DTXSID8046169 Css NA 0.0003328 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046169 Css NA 0.002988 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046169 Css NA 0.0003145 mg/L PBTK NA 50% Rat Human +DTXSID8046169 Css NA 0.002762 mg/L PBTK NA 95% Rat Human +DTXSID8046240 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046240 Fup 0.0654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046240 Vd NA 0.36 L/kg 1compartment NA NA Human Human DTXSID8046240 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046240 TK.Half.Life NA 4.245 hours 1compartment NA NA Human Human -DTXSID8046240 Css NA 2.746 mg/L 3compartmentss NA 50% Human Human -DTXSID8046240 Css NA 22.12 mg/L 3compartmentss NA 95% Human Human -DTXSID8046240 Css NA 1.655 mg/L PBTK NA 50% Human Human -DTXSID8046240 Css NA 12.91 mg/L PBTK NA 95% Human Human -DTXSID8046240 Clint NA 7.439 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046240 Fup NA 0.0329 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046240 Vd NA 0.2647 L/kg 1compartment NA NA Rat Human +DTXSID8046240 TK.Half.Life NA 3.396 hours 1compartment NA NA Human Human +DTXSID8046240 Css NA 1.386 mg/L 3compartmentss NA 50% Human Human +DTXSID8046240 Css NA 8.955 mg/L 3compartmentss NA 95% Human Human +DTXSID8046240 Css NA 0.875 mg/L PBTK NA 50% Human Human +DTXSID8046240 Css NA 5.447 mg/L PBTK NA 95% Human Human +DTXSID8046240 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046240 Fup 0.0654 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046240 Vd NA 0.3493 L/kg 1compartment NA NA Rat Human DTXSID8046240 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046240 TK.Half.Life NA 2.614 hours 1compartment NA NA Rat Human -DTXSID8046240 Css NA 1.493 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046240 Css NA 9.174 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046240 Css NA 0.8447 mg/L PBTK NA 50% Rat Human -DTXSID8046240 Css NA 5.014 mg/L PBTK NA 95% Rat Human -DTXSID8046242 Clint NA 57.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046242 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046242 Vd NA 1.217 L/kg 1compartment NA NA Human Human +DTXSID8046240 TK.Half.Life NA 2.043 hours 1compartment NA NA Rat Human +DTXSID8046240 Css NA 0.1713 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046240 Css NA 0.8122 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046240 Css NA 0.1053 mg/L PBTK NA 50% Rat Human +DTXSID8046240 Css NA 0.4718 mg/L PBTK NA 95% Rat Human +DTXSID8046242 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046242 Fup 0.0497 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046242 Vd NA 1.833 L/kg 1compartment NA NA Human Human DTXSID8046242 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046242 TK.Half.Life NA 3.234 hours 1compartment NA NA Human Human -DTXSID8046242 Css NA 0.321 mg/L 3compartmentss NA 50% Human Human -DTXSID8046242 Css NA 2.792 mg/L 3compartmentss NA 95% Human Human -DTXSID8046242 Css NA 0.1997 mg/L PBTK NA 50% Human Human -DTXSID8046242 Css NA 1.655 mg/L PBTK NA 95% Human Human -DTXSID8046242 Clint NA 57.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046242 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046242 Vd NA 0.914 L/kg 1compartment NA NA Rat Human +DTXSID8046242 TK.Half.Life NA 9.44 hours 1compartment NA NA Human Human +DTXSID8046242 Css NA 0.6742 mg/L 3compartmentss NA 50% Human Human +DTXSID8046242 Css NA 5.328 mg/L 3compartmentss NA 95% Human Human +DTXSID8046242 Css NA 0.4362 mg/L PBTK NA 50% Human Human +DTXSID8046242 Css NA 3.315 mg/L PBTK NA 95% Human Human +DTXSID8046242 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046242 Fup 0.0497 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046242 Vd NA 1.374 L/kg 1compartment NA NA Rat Human DTXSID8046242 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046242 TK.Half.Life NA 1.299 hours 1compartment NA NA Rat Human -DTXSID8046242 Css NA 0.1829 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046242 Css NA 1.362 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046242 Css NA 0.1074 mg/L PBTK NA 50% Rat Human -DTXSID8046242 Css NA 0.7759 mg/L PBTK NA 95% Rat Human -DTXSID8046244 Clint NA 0.3384 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046244 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046244 Vd NA 0.2181 L/kg 1compartment NA NA Human Human -DTXSID8046244 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID8046244 TK.Half.Life NA 86.54 hours 1compartment NA NA Human Human -DTXSID8046244 Css NA 67.12 mg/L 3compartmentss NA 50% Human Human -DTXSID8046244 Css NA 433.2 mg/L 3compartmentss NA 95% Human Human -DTXSID8046244 Css NA 39.7 mg/L PBTK NA 50% Human Human -DTXSID8046244 Css NA 250.3 mg/L PBTK NA 95% Human Human -DTXSID8046244 Clint NA 0.3384 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046244 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046244 Vd NA 0.2087 L/kg 1compartment NA NA Rat Human -DTXSID8046244 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID8046244 TK.Half.Life NA 34.66 hours 1compartment NA NA Rat Human -DTXSID8046244 Css NA 24.04 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046244 Css NA 139.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046244 Css NA 13.22 mg/L PBTK NA 50% Rat Human -DTXSID8046244 Css NA 75.66 mg/L PBTK NA 95% Rat Human -DTXSID8046246 Clint NA 34.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046246 Fup NA 0.2785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046246 Vd NA 0.5276 L/kg 1compartment NA NA Human Human -DTXSID8046246 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046246 TK.Half.Life NA 0.6161 hours 1compartment NA NA Human Human -DTXSID8046246 Css NA 0.051 mg/L 3compartmentss NA 50% Human Human -DTXSID8046246 Css NA 0.3848 mg/L 3compartmentss NA 95% Human Human -DTXSID8046246 Css NA 0.03536 mg/L PBTK NA 50% Human Human -DTXSID8046246 Css NA 0.2523 mg/L PBTK NA 95% Human Human -DTXSID8046246 Clint NA 34.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046246 Fup NA 0.2785 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046246 Vd NA 0.4868 L/kg 1compartment NA NA Rat Human +DTXSID8046242 TK.Half.Life NA 3.276 hours 1compartment NA NA Rat Human +DTXSID8046242 Css NA 0.08796 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046242 Css NA 0.5134 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046242 Css NA 0.05594 mg/L PBTK NA 50% Rat Human +DTXSID8046242 Css NA 0.3179 mg/L PBTK NA 95% Rat Human +DTXSID8046244 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046244 Fup 0.0179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046244 Vd NA 1.842 L/kg 1compartment NA NA Human Human +DTXSID8046244 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046244 TK.Half.Life NA 19.45 hours 1compartment NA NA Human Human +DTXSID8046244 Css NA 1.59 mg/L 3compartmentss NA 50% Human Human +DTXSID8046244 Css NA 13.2 mg/L 3compartmentss NA 95% Human Human +DTXSID8046244 Css NA 1.014 mg/L PBTK NA 50% Human Human +DTXSID8046244 Css NA 8.145 mg/L PBTK NA 95% Human Human +DTXSID8046244 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046244 Fup 0.0179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046244 Vd NA 1.366 L/kg 1compartment NA NA Rat Human +DTXSID8046244 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8046244 TK.Half.Life NA 6.665 hours 1compartment NA NA Rat Human +DTXSID8046244 Css NA 0.2069 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046244 Css NA 1.439 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046244 Css NA 0.1282 mg/L PBTK NA 50% Rat Human +DTXSID8046244 Css NA 0.8571 mg/L PBTK NA 95% Rat Human +DTXSID8046246 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046246 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046246 Vd NA 0.708 L/kg 1compartment NA NA Human Human +DTXSID8046246 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046246 TK.Half.Life NA 10.59 hours 1compartment NA NA Human Human +DTXSID8046246 Css NA 1.59 mg/L 3compartmentss NA 50% Human Human +DTXSID8046246 Css NA 7.293 mg/L 3compartmentss NA 95% Human Human +DTXSID8046246 Css NA 1.215 mg/L PBTK NA 50% Human Human +DTXSID8046246 Css NA 4.688 mg/L PBTK NA 95% Human Human +DTXSID8046246 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046246 Fup 0.445 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046246 Vd NA 0.6494 L/kg 1compartment NA NA Rat Human DTXSID8046246 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046246 TK.Half.Life NA 0.2894 hours 1compartment NA NA Rat Human -DTXSID8046246 Css NA 0.02752 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046246 Css NA 0.1619 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046246 Css NA 0.01813 mg/L PBTK NA 50% Rat Human -DTXSID8046246 Css NA 0.1004 mg/L PBTK NA 95% Rat Human -DTXSID8046248 Clint NA 36.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046248 Fup NA 0.2714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046248 Vd NA 4.612 L/kg 1compartment NA NA Human Human +DTXSID8046246 TK.Half.Life NA 3.239 hours 1compartment NA NA Rat Human +DTXSID8046246 Css NA 0.1014 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046246 Css NA 0.4106 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046246 Css NA 0.0764 mg/L PBTK NA 50% Rat Human +DTXSID8046246 Css NA 0.2538 mg/L PBTK NA 95% Rat Human +DTXSID8046248 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046248 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046248 Vd NA 3.055 L/kg 1compartment NA NA Human Human DTXSID8046248 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046248 TK.Half.Life NA 1.893 hours 1compartment NA NA Human Human -DTXSID8046248 Css NA 0.005467 mg/L 3compartmentss NA 50% Human Human -DTXSID8046248 Css NA 0.05429 mg/L 3compartmentss NA 95% Human Human -DTXSID8046248 Css NA 0.009138 mg/L PBTK NA 50% Human Human -DTXSID8046248 Css NA 0.06513 mg/L PBTK NA 95% Human Human -DTXSID8046248 Clint NA 36.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046248 Fup NA 0.2714 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046248 Vd NA 4.547 L/kg 1compartment NA NA Rat Human +DTXSID8046248 TK.Half.Life NA 2.375 hours 1compartment NA NA Human Human +DTXSID8046248 Css NA 0.024 mg/L 3compartmentss NA 50% Human Human +DTXSID8046248 Css NA 0.2226 mg/L 3compartmentss NA 95% Human Human +DTXSID8046248 Css NA 0.02971 mg/L PBTK NA 50% Human Human +DTXSID8046248 Css NA 0.2198 mg/L PBTK NA 95% Human Human +DTXSID8046248 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046248 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046248 Vd NA 3.009 L/kg 1compartment NA NA Rat Human DTXSID8046248 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046248 TK.Half.Life NA 0.9104 hours 1compartment NA NA Rat Human -DTXSID8046248 Css NA 0.002811 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046248 Css NA 0.02273 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046248 Css NA 0.004868 mg/L PBTK NA 50% Rat Human -DTXSID8046248 Css NA 0.02831 mg/L PBTK NA 95% Rat Human -DTXSID8046290 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046290 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046290 Vd NA 0.6488 L/kg 1compartment NA NA Human Human -DTXSID8046290 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046290 TK.Half.Life NA 5.475 hours 1compartment NA NA Human Human -DTXSID8046290 Css NA 1.031 mg/L 3compartmentss NA 50% Human Human -DTXSID8046290 Css NA 6.305 mg/L 3compartmentss NA 95% Human Human -DTXSID8046290 Css NA 0.8386 mg/L PBTK NA 50% Human Human -DTXSID8046290 Css NA 4.082 mg/L PBTK NA 95% Human Human -DTXSID8046290 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046290 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046290 Vd NA 0.7024 L/kg 1compartment NA NA Rat Human -DTXSID8046290 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046290 TK.Half.Life NA 2.02 hours 1compartment NA NA Rat Human -DTXSID8046290 Css NA 0.2628 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046290 Css NA 1.666 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046290 Css NA 0.2078 mg/L PBTK NA 50% Rat Human -DTXSID8046290 Css NA 0.9876 mg/L PBTK NA 95% Rat Human -DTXSID8046292 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046292 Fup NA 0.0786 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046292 Vd NA 0.268 L/kg 1compartment NA NA Human Human -DTXSID8046292 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8046292 TK.Half.Life NA 22.06 hours 1compartment NA NA Human Human -DTXSID8046292 Css NA 13.31 mg/L 3compartmentss NA 50% Human Human -DTXSID8046292 Css NA 58.85 mg/L 3compartmentss NA 95% Human Human -DTXSID8046292 Css NA 8.148 mg/L PBTK NA 50% Human Human -DTXSID8046292 Css NA 34.65 mg/L PBTK NA 95% Human Human -DTXSID8046292 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046292 Fup NA 0.0786 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046292 Vd NA 0.2641 L/kg 1compartment NA NA Rat Human +DTXSID8046248 TK.Half.Life NA 1.276 hours 1compartment NA NA Rat Human +DTXSID8046248 Css NA 0.002934 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046248 Css NA 0.02229 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046248 Css NA 0.003832 mg/L PBTK NA 50% Rat Human +DTXSID8046248 Css NA 0.02239 mg/L PBTK NA 95% Rat Human +DTXSID8046292 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046292 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046292 Vd NA 0.3221 L/kg 1compartment NA NA Human Human +DTXSID8046292 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8046292 TK.Half.Life NA 1.392 hours 1compartment NA NA Human Human +DTXSID8046292 Css NA 0.5178 mg/L 3compartmentss NA 50% Human Human +DTXSID8046292 Css NA 3.366 mg/L 3compartmentss NA 95% Human Human +DTXSID8046292 Css NA 0.331 mg/L PBTK NA 50% Human Human +DTXSID8046292 Css NA 2.062 mg/L PBTK NA 95% Human Human +DTXSID8046292 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046292 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046292 Vd NA 0.3206 L/kg 1compartment NA NA Rat Human DTXSID8046292 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046292 TK.Half.Life NA 7.409 hours 1compartment NA NA Rat Human -DTXSID8046292 Css NA 3.724 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046292 Css NA 14.36 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046292 Css NA 2.133 mg/L PBTK NA 50% Rat Human -DTXSID8046292 Css NA 7.885 mg/L PBTK NA 95% Rat Human -DTXSID8046294 Clint NA 17.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046294 Fup NA 0.0669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046294 Vd NA 2.395 L/kg 1compartment NA NA Human Human +DTXSID8046292 TK.Half.Life NA 0.8255 hours 1compartment NA NA Rat Human +DTXSID8046292 Css NA 0.06356 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046292 Css NA 0.3009 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046292 Css NA 0.03974 mg/L PBTK NA 50% Rat Human +DTXSID8046292 Css NA 0.1773 mg/L PBTK NA 95% Rat Human +DTXSID8046294 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046294 Fup 0.0854 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046294 Vd NA 2.506 L/kg 1compartment NA NA Human Human DTXSID8046294 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046294 TK.Half.Life NA 10.05 hours 1compartment NA NA Human Human -DTXSID8046294 Css NA 0.505 mg/L 3compartmentss NA 50% Human Human -DTXSID8046294 Css NA 3.751 mg/L 3compartmentss NA 95% Human Human -DTXSID8046294 Css NA 0.3632 mg/L PBTK NA 50% Human Human -DTXSID8046294 Css NA 2.498 mg/L PBTK NA 95% Human Human -DTXSID8046294 Clint NA 17.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046294 Fup NA 0.0669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046294 Vd NA 1.985 L/kg 1compartment NA NA Rat Human +DTXSID8046294 TK.Half.Life NA 7.513 hours 1compartment NA NA Human Human +DTXSID8046294 Css NA 0.3016 mg/L 3compartmentss NA 50% Human Human +DTXSID8046294 Css NA 2.321 mg/L 3compartmentss NA 95% Human Human +DTXSID8046294 Css NA 0.225 mg/L PBTK NA 50% Human Human +DTXSID8046294 Css NA 1.595 mg/L PBTK NA 95% Human Human +DTXSID8046294 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046294 Fup 0.0854 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046294 Vd NA 2.104 L/kg 1compartment NA NA Rat Human DTXSID8046294 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046294 TK.Half.Life NA 3.83 hours 1compartment NA NA Rat Human -DTXSID8046294 Css NA 0.2812 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046294 Css NA 1.524 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046294 Css NA 0.1927 mg/L PBTK NA 50% Rat Human -DTXSID8046294 Css NA 0.9694 mg/L PBTK NA 95% Rat Human -DTXSID8046296 Clint NA 121.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046296 Fup NA 0.0241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046296 Vd NA 2.228 L/kg 1compartment NA NA Human Human -DTXSID8046296 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046296 TK.Half.Life NA 5.506 hours 1compartment NA NA Human Human -DTXSID8046296 Css NA 0.2595 mg/L 3compartmentss NA 50% Human Human -DTXSID8046296 Css NA 2.035 mg/L 3compartmentss NA 95% Human Human -DTXSID8046296 Css NA 0.1696 mg/L PBTK NA 50% Human Human -DTXSID8046296 Css NA 1.268 mg/L PBTK NA 95% Human Human -DTXSID8046296 Clint NA 121.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046296 Fup NA 0.0241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046296 Vd NA 1.661 L/kg 1compartment NA NA Rat Human +DTXSID8046294 TK.Half.Life NA 2.883 hours 1compartment NA NA Rat Human +DTXSID8046294 Css NA 0.039 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046294 Css NA 0.2376 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046294 Css NA 0.02869 mg/L PBTK NA 50% Rat Human +DTXSID8046294 Css NA 0.1619 mg/L PBTK NA 95% Rat Human +DTXSID8046296 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046296 Fup 0.0618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046296 Vd NA 2.421 L/kg 1compartment NA NA Human Human +DTXSID8046296 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046296 TK.Half.Life NA 14.03 hours 1compartment NA NA Human Human +DTXSID8046296 Css NA 0.7248 mg/L 3compartmentss NA 50% Human Human +DTXSID8046296 Css NA 4.936 mg/L 3compartmentss NA 95% Human Human +DTXSID8046296 Css NA 0.4873 mg/L PBTK NA 50% Human Human +DTXSID8046296 Css NA 3.201 mg/L PBTK NA 95% Human Human +DTXSID8046296 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046296 Fup 0.0618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046296 Vd NA 1.819 L/kg 1compartment NA NA Rat Human DTXSID8046296 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046296 TK.Half.Life NA 1.67 hours 1compartment NA NA Rat Human -DTXSID8046296 Css NA 0.1458 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046296 Css NA 0.9628 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046296 Css NA 0.0897 mg/L PBTK NA 50% Rat Human -DTXSID8046296 Css NA 0.5697 mg/L PBTK NA 95% Rat Human -DTXSID8046298 Clint NA 0.3879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046298 Fup NA 0.9666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046298 Vd NA 1.466 L/kg 1compartment NA NA Human Human -DTXSID8046298 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046298 TK.Half.Life NA 6.736 hours 1compartment NA NA Human Human -DTXSID8046298 Css NA 0.4614 mg/L 3compartmentss NA 50% Human Human -DTXSID8046298 Css NA 1.754 mg/L 3compartmentss NA 95% Human Human -DTXSID8046298 Css NA 0.4317 mg/L PBTK NA 50% Human Human -DTXSID8046298 Css NA 1.338 mg/L PBTK NA 95% Human Human -DTXSID8046298 Clint NA 0.3879 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046298 Fup NA 0.9666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046298 Vd NA 1.331 L/kg 1compartment NA NA Rat Human +DTXSID8046296 TK.Half.Life NA 3.784 hours 1compartment NA NA Rat Human +DTXSID8046296 Css NA 0.0925 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046296 Css NA 0.5239 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046296 Css NA 0.06153 mg/L PBTK NA 50% Rat Human +DTXSID8046296 Css NA 0.3335 mg/L PBTK NA 95% Rat Human +DTXSID8046298 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046298 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046298 Vd NA 0.8785 L/kg 1compartment NA NA Human Human +DTXSID8046298 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046298 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human +DTXSID8046298 Css NA 1.389 mg/L 3compartmentss NA 50% Human Human +DTXSID8046298 Css NA 7.698 mg/L 3compartmentss NA 95% Human Human +DTXSID8046298 Css NA 1.112 mg/L PBTK NA 50% Human Human +DTXSID8046298 Css NA 4.946 mg/L PBTK NA 95% Human Human +DTXSID8046298 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046298 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046298 Vd NA 0.8154 L/kg 1compartment NA NA Rat Human DTXSID8046298 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046298 TK.Half.Life NA 2.384 hours 1compartment NA NA Rat Human -DTXSID8046298 Css NA 0.1504 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046298 Css NA 0.5084 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046298 Css NA 0.1401 mg/L PBTK NA 50% Rat Human -DTXSID8046298 Css NA 0.358 mg/L PBTK NA 95% Rat Human -DTXSID8046321 Clint NA 0.5017 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046321 Fup NA 0.7369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046321 Vd NA 1.737 L/kg 1compartment NA NA Human Human -DTXSID8046321 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046321 TK.Half.Life NA 9.632 hours 1compartment NA NA Human Human -DTXSID8046321 Css NA 0.5304 mg/L 3compartmentss NA 50% Human Human -DTXSID8046321 Css NA 3.407 mg/L 3compartmentss NA 95% Human Human -DTXSID8046321 Css NA 0.5014 mg/L PBTK NA 50% Human Human -DTXSID8046321 Css NA 2.314 mg/L PBTK NA 95% Human Human -DTXSID8046321 Clint NA 0.5017 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046321 Fup NA 0.7369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046321 Vd NA 1.582 L/kg 1compartment NA NA Rat Human +DTXSID8046298 TK.Half.Life NA 3.597 hours 1compartment NA NA Rat Human +DTXSID8046298 Css NA 0.08606 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046298 Css NA 0.423 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046298 Css NA 0.06832 mg/L PBTK NA 50% Rat Human +DTXSID8046298 Css NA 0.2626 mg/L PBTK NA 95% Rat Human +DTXSID8046321 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046321 Fup 0.541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046321 Vd NA 1.453 L/kg 1compartment NA NA Human Human +DTXSID8046321 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8046321 TK.Half.Life NA 19.29 hours 1compartment NA NA Human Human +DTXSID8046321 Css NA 1.279 mg/L 3compartmentss NA 50% Human Human +DTXSID8046321 Css NA 7.934 mg/L 3compartmentss NA 95% Human Human +DTXSID8046321 Css NA 1.112 mg/L PBTK NA 50% Human Human +DTXSID8046321 Css NA 5.166 mg/L PBTK NA 95% Human Human +DTXSID8046321 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046321 Fup 0.541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046321 Vd NA 1.318 L/kg 1compartment NA NA Rat Human DTXSID8046321 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046321 TK.Half.Life NA 3.492 hours 1compartment NA NA Rat Human -DTXSID8046321 Css NA 0.1797 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046321 Css NA 1.212 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046321 Css NA 0.1664 mg/L PBTK NA 50% Rat Human -DTXSID8046321 Css NA 0.7554 mg/L PBTK NA 95% Rat Human -DTXSID8046323 Clint NA 23.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046323 Fup NA 0.1791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046323 Vd NA 0.6777 L/kg 1compartment NA NA Human Human -DTXSID8046323 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046323 TK.Half.Life NA 1.141 hours 1compartment NA NA Human Human -DTXSID8046323 Css NA 0.1168 mg/L 3compartmentss NA 50% Human Human -DTXSID8046323 Css NA 0.7883 mg/L 3compartmentss NA 95% Human Human -DTXSID8046323 Css NA 0.07861 mg/L PBTK NA 50% Human Human -DTXSID8046323 Css NA 0.5059 mg/L PBTK NA 95% Human Human -DTXSID8046323 Clint NA 23.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046323 Fup NA 0.1791 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046323 Vd NA 0.5901 L/kg 1compartment NA NA Rat Human +DTXSID8046321 TK.Half.Life NA 5.514 hours 1compartment NA NA Rat Human +DTXSID8046321 Css NA 0.07883 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046321 Css NA 0.4495 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046321 Css NA 0.06881 mg/L PBTK NA 50% Rat Human +DTXSID8046321 Css NA 0.2855 mg/L PBTK NA 95% Rat Human +DTXSID8046323 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046323 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046323 Vd NA 0.8589 L/kg 1compartment NA NA Human Human +DTXSID8046323 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046323 TK.Half.Life NA 10.85 hours 1compartment NA NA Human Human +DTXSID8046323 Css NA 1.332 mg/L 3compartmentss NA 50% Human Human +DTXSID8046323 Css NA 7.545 mg/L 3compartmentss NA 95% Human Human +DTXSID8046323 Css NA 1.069 mg/L PBTK NA 50% Human Human +DTXSID8046323 Css NA 4.893 mg/L PBTK NA 95% Human Human +DTXSID8046323 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046323 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046323 Vd NA 0.8127 L/kg 1compartment NA NA Rat Human DTXSID8046323 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046323 TK.Half.Life NA 0.5449 hours 1compartment NA NA Rat Human -DTXSID8046323 Css NA 0.06376 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046323 Css NA 0.3395 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046323 Css NA 0.0408 mg/L PBTK NA 50% Rat Human -DTXSID8046323 Css NA 0.2055 mg/L PBTK NA 95% Rat Human -DTXSID8046325 Clint NA 3.536 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046325 Fup NA 0.3226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046325 Vd NA 2.348 L/kg 1compartment NA NA Human Human +DTXSID8046323 TK.Half.Life NA 3.428 hours 1compartment NA NA Rat Human +DTXSID8046323 Css NA 0.08207 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046323 Css NA 0.4323 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046323 Css NA 0.06558 mg/L PBTK NA 50% Rat Human +DTXSID8046323 Css NA 0.2669 mg/L PBTK NA 95% Rat Human +DTXSID8046325 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046325 Fup 0.505 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046325 Vd NA 1.166 L/kg 1compartment NA NA Human Human DTXSID8046325 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046325 TK.Half.Life NA 8.212 hours 1compartment NA NA Human Human -DTXSID8046325 Css NA 0.2872 mg/L 3compartmentss NA 50% Human Human -DTXSID8046325 Css NA 1.733 mg/L 3compartmentss NA 95% Human Human -DTXSID8046325 Css NA 0.2666 mg/L PBTK NA 50% Human Human -DTXSID8046325 Css NA 1.333 mg/L PBTK NA 95% Human Human -DTXSID8046325 Clint NA 3.536 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046325 Fup NA 0.3226 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046325 Vd NA 2.255 L/kg 1compartment NA NA Rat Human +DTXSID8046325 TK.Half.Life NA 1.929 hours 1compartment NA NA Human Human +DTXSID8046325 Css NA 0.1174 mg/L 3compartmentss NA 50% Human Human +DTXSID8046325 Css NA 0.9463 mg/L 3compartmentss NA 95% Human Human +DTXSID8046325 Css NA 0.09864 mg/L PBTK NA 50% Human Human +DTXSID8046325 Css NA 0.6558 mg/L PBTK NA 95% Human Human +DTXSID8046325 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046325 Fup 0.505 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046325 Vd NA 1.181 L/kg 1compartment NA NA Rat Human DTXSID8046325 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046325 TK.Half.Life NA 4.214 hours 1compartment NA NA Rat Human -DTXSID8046325 Css NA 0.1346 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046325 Css NA 0.6519 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046325 Css NA 0.1236 mg/L PBTK NA 50% Rat Human -DTXSID8046325 Css NA 0.4517 mg/L PBTK NA 95% Rat Human -DTXSID8046327 Clint NA 2.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046327 Fup NA 0.5203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046327 Vd NA 2.122 L/kg 1compartment NA NA Human Human -DTXSID8046327 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046327 TK.Half.Life NA 6.161 hours 1compartment NA NA Human Human -DTXSID8046327 Css NA 0.2364 mg/L 3compartmentss NA 50% Human Human -DTXSID8046327 Css NA 1.732 mg/L 3compartmentss NA 95% Human Human -DTXSID8046327 Css NA 0.2345 mg/L PBTK NA 50% Human Human -DTXSID8046327 Css NA 1.28 mg/L PBTK NA 95% Human Human -DTXSID8046327 Clint NA 2.301 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046327 Fup NA 0.5203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046327 Vd NA 2.147 L/kg 1compartment NA NA Rat Human +DTXSID8046325 TK.Half.Life NA 1.082 hours 1compartment NA NA Rat Human +DTXSID8046325 Css NA 0.01355 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046325 Css NA 0.08744 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046325 Css NA 0.0114 mg/L PBTK NA 50% Rat Human +DTXSID8046325 Css NA 0.05817 mg/L PBTK NA 95% Rat Human +DTXSID8046327 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046327 Fup 0.477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046327 Vd NA 1.862 L/kg 1compartment NA NA Human Human +DTXSID8046327 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8046327 TK.Half.Life NA 25.87 hours 1compartment NA NA Human Human +DTXSID8046327 Css NA 1.213 mg/L 3compartmentss NA 50% Human Human +DTXSID8046327 Css NA 6.48 mg/L 3compartmentss NA 95% Human Human +DTXSID8046327 Css NA 1.136 mg/L PBTK NA 50% Human Human +DTXSID8046327 Css NA 4.548 mg/L PBTK NA 95% Human Human +DTXSID8046327 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046327 Fup 0.477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046327 Vd NA 1.854 L/kg 1compartment NA NA Rat Human DTXSID8046327 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046327 TK.Half.Life NA 3.385 hours 1compartment NA NA Rat Human -DTXSID8046327 Css NA 0.1021 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046327 Css NA 0.6625 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046327 Css NA 0.1006 mg/L PBTK NA 50% Rat Human -DTXSID8046327 Css NA 0.4456 mg/L PBTK NA 95% Rat Human -DTXSID8046400 Clint NA 49.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046400 Fup NA 0.0864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046400 Vd NA 3.79 L/kg 1compartment NA NA Human Human +DTXSID8046327 TK.Half.Life NA 8.619 hours 1compartment NA NA Rat Human +DTXSID8046327 Css NA 0.07519 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046327 Css NA 0.37 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046327 Css NA 0.07128 mg/L PBTK NA 50% Rat Human +DTXSID8046327 Css NA 0.2485 mg/L PBTK NA 95% Rat Human +DTXSID8046400 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046400 Fup 0.0782 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046400 Vd NA 1.075 L/kg 1compartment NA NA Human Human DTXSID8046400 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046400 TK.Half.Life NA 3.276 hours 1compartment NA NA Human Human -DTXSID8046400 Css NA 0.02375 mg/L 3compartmentss NA 50% Human Human -DTXSID8046400 Css NA 0.1686 mg/L 3compartmentss NA 95% Human Human -DTXSID8046400 Css NA 0.02026 mg/L PBTK NA 50% Human Human -DTXSID8046400 Css NA 0.1316 mg/L PBTK NA 95% Human Human -DTXSID8046400 Clint NA 49.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046400 Fup NA 0.0864 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046400 Vd NA 3.181 L/kg 1compartment NA NA Rat Human +DTXSID8046400 TK.Half.Life NA 3.032 hours 1compartment NA NA Human Human +DTXSID8046400 Css NA 0.3129 mg/L 3compartmentss NA 50% Human Human +DTXSID8046400 Css NA 2.695 mg/L 3compartmentss NA 95% Human Human +DTXSID8046400 Css NA 0.2151 mg/L PBTK NA 50% Human Human +DTXSID8046400 Css NA 1.699 mg/L PBTK NA 95% Human Human +DTXSID8046400 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046400 Fup 0.0782 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046400 Vd NA 1.061 L/kg 1compartment NA NA Rat Human DTXSID8046400 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046400 TK.Half.Life NA 1.071 hours 1compartment NA NA Rat Human -DTXSID8046400 Css NA 0.01308 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046400 Css NA 0.07672 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046400 Css NA 0.01088 mg/L PBTK NA 50% Rat Human -DTXSID8046400 Css NA 0.06027 mg/L PBTK NA 95% Rat Human -DTXSID8046402 Clint NA 4.076 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046402 Fup NA 0.4777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046402 Vd NA 0.4071 L/kg 1compartment NA NA Human Human +DTXSID8046400 TK.Half.Life NA 1.829 hours 1compartment NA NA Rat Human +DTXSID8046400 Css NA 0.04106 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046400 Css NA 0.264 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046400 Css NA 0.02746 mg/L PBTK NA 50% Rat Human +DTXSID8046400 Css NA 0.1604 mg/L PBTK NA 95% Rat Human +DTXSID8046402 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046402 Fup 0.396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046402 Vd NA 0.3719 L/kg 1compartment NA NA Human Human DTXSID8046402 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046402 TK.Half.Life NA 0.9322 hours 1compartment NA NA Human Human -DTXSID8046402 Css NA 0.2165 mg/L 3compartmentss NA 50% Human Human -DTXSID8046402 Css NA 1.404 mg/L 3compartmentss NA 95% Human Human -DTXSID8046402 Css NA 0.1538 mg/L PBTK NA 50% Human Human -DTXSID8046402 Css NA 0.8986 mg/L PBTK NA 95% Human Human -DTXSID8046402 Clint NA 4.076 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046402 Fup NA 0.4777 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046402 Vd NA 0.4166 L/kg 1compartment NA NA Rat Human +DTXSID8046402 TK.Half.Life NA 0.4379 hours 1compartment NA NA Human Human +DTXSID8046402 Css NA 0.05222 mg/L 3compartmentss NA 50% Human Human +DTXSID8046402 Css NA 0.3963 mg/L 3compartmentss NA 95% Human Human +DTXSID8046402 Css NA 0.036 mg/L PBTK NA 50% Human Human +DTXSID8046402 Css NA 0.2529 mg/L PBTK NA 95% Human Human +DTXSID8046402 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046402 Fup 0.396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046402 Vd NA 0.3799 L/kg 1compartment NA NA Rat Human DTXSID8046402 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046402 TK.Half.Life NA 0.5231 hours 1compartment NA NA Rat Human -DTXSID8046402 Css NA 0.1044 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046402 Css NA 0.5424 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046402 Css NA 0.07056 mg/L PBTK NA 50% Rat Human -DTXSID8046402 Css NA 0.3202 mg/L PBTK NA 95% Rat Human -DTXSID8046404 Clint NA 6.364 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046404 Fup NA 0.4509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046404 Vd NA 0.9186 L/kg 1compartment NA NA Human Human +DTXSID8046402 TK.Half.Life NA 0.2284 hours 1compartment NA NA Rat Human +DTXSID8046402 Css NA 0.006389 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046402 Css NA 0.03929 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046402 Css NA 0.004344 mg/L PBTK NA 50% Rat Human +DTXSID8046402 Css NA 0.02477 mg/L PBTK NA 95% Rat Human +DTXSID8046404 Clint 51 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID8046404 Fup 0.036 NA NA Williamson 2020 NA Human Human +DTXSID8046404 Vd NA 0.3315 L/kg 1compartment NA NA Human Human DTXSID8046404 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046404 TK.Half.Life NA 1.692 hours 1compartment NA NA Human Human -DTXSID8046404 Css NA 0.1427 mg/L 3compartmentss NA 50% Human Human -DTXSID8046404 Css NA 0.9946 mg/L 3compartmentss NA 95% Human Human -DTXSID8046404 Css NA 0.1131 mg/L PBTK NA 50% Human Human -DTXSID8046404 Css NA 0.6742 mg/L PBTK NA 95% Human Human -DTXSID8046404 Clint NA 6.364 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046404 Fup NA 0.4509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046404 Vd NA 0.8418 L/kg 1compartment NA NA Rat Human +DTXSID8046404 TK.Half.Life NA 0.9857 hours 1compartment NA NA Human Human +DTXSID8046404 Css NA 0.3856 mg/L 3compartmentss NA 50% Human Human +DTXSID8046404 Css NA 3.367 mg/L 3compartmentss NA 95% Human Human +DTXSID8046404 Css NA 0.2286 mg/L PBTK NA 50% Human Human +DTXSID8046404 Css NA 1.985 mg/L PBTK NA 95% Human Human +DTXSID8046404 Clint 51 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID8046404 Fup 0.036 NA NA Williamson 2020 NA Rat Human +DTXSID8046404 Vd NA 0.2895 L/kg 1compartment NA NA Rat Human DTXSID8046404 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046404 TK.Half.Life NA 0.8432 hours 1compartment NA NA Rat Human -DTXSID8046404 Css NA 0.07179 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046404 Css NA 0.3959 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046404 Css NA 0.05486 mg/L PBTK NA 50% Rat Human -DTXSID8046404 Css NA 0.2472 mg/L PBTK NA 95% Rat Human -DTXSID8046406 Clint NA 39.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046406 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046406 Vd NA 0.2317 L/kg 1compartment NA NA Human Human +DTXSID8046404 TK.Half.Life NA 0.5227 hours 1compartment NA NA Rat Human +DTXSID8046404 Css NA 0.05164 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046404 Css NA 0.3457 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046404 Css NA 0.02977 mg/L PBTK NA 50% Rat Human +DTXSID8046404 Css NA 0.1969 mg/L PBTK NA 95% Rat Human +DTXSID8046406 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046406 Fup 0.0377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046406 Vd NA 0.3102 L/kg 1compartment NA NA Human Human DTXSID8046406 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046406 TK.Half.Life NA 1.701 hours 1compartment NA NA Human Human -DTXSID8046406 Css NA 1.26 mg/L 3compartmentss NA 50% Human Human -DTXSID8046406 Css NA 12.32 mg/L 3compartmentss NA 95% Human Human -DTXSID8046406 Css NA 0.7404 mg/L PBTK NA 50% Human Human -DTXSID8046406 Css NA 7.208 mg/L PBTK NA 95% Human Human -DTXSID8046406 Clint NA 39.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046406 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046406 Vd NA 0.2107 L/kg 1compartment NA NA Rat Human +DTXSID8046406 TK.Half.Life NA 1.684 hours 1compartment NA NA Human Human +DTXSID8046406 Css NA 0.839 mg/L 3compartmentss NA 50% Human Human +DTXSID8046406 Css NA 7.957 mg/L 3compartmentss NA 95% Human Human +DTXSID8046406 Css NA 0.4994 mg/L PBTK NA 50% Human Human +DTXSID8046406 Css NA 4.657 mg/L PBTK NA 95% Human Human +DTXSID8046406 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046406 Fup 0.0377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046406 Vd NA 0.2751 L/kg 1compartment NA NA Rat Human DTXSID8046406 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046406 TK.Half.Life NA 1.016 hours 1compartment NA NA Rat Human -DTXSID8046406 Css NA 0.7127 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046406 Css NA 5.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046406 Css NA 0.3904 mg/L PBTK NA 50% Rat Human -DTXSID8046406 Css NA 3.224 mg/L PBTK NA 95% Rat Human -DTXSID8046450 Clint NA 24.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046450 Fup NA 0.0016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046450 Vd NA 256.1 L/kg 1compartment NA NA Human Human -DTXSID8046450 Days.Css NA 3459 Days PBTK NA NA Human Human -DTXSID8046450 TK.Half.Life NA 12670 hours 1compartment NA NA Human Human -DTXSID8046450 Css NA 0.1976 mg/L 3compartmentss NA 50% Human Human -DTXSID8046450 Css NA 5.823 mg/L 3compartmentss NA 95% Human Human -DTXSID8046450 Css NA 5.456 mg/L PBTK NA 50% Human Human -DTXSID8046450 Css NA 50.64 mg/L PBTK NA 95% Human Human -DTXSID8046450 Clint NA 24.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046450 Fup NA 0.0016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046450 Vd NA 227.7 L/kg 1compartment NA NA Rat Human -DTXSID8046450 Days.Css NA 2168 Days PBTK NA NA Rat Human -DTXSID8046450 TK.Half.Life NA 7119 hours 1compartment NA NA Rat Human -DTXSID8046450 Css NA 0.09704 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046450 Css NA 2.594 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046450 Css NA 2.956 mg/L PBTK NA 50% Rat Human -DTXSID8046450 Css NA 21.51 mg/L PBTK NA 95% Rat Human -DTXSID8046452 Clint NA 98.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046452 Fup NA 0.0068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046452 Vd NA 1.449 L/kg 1compartment NA NA Human Human -DTXSID8046452 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046452 TK.Half.Life NA 7.236 hours 1compartment NA NA Human Human -DTXSID8046452 Css NA 0.7358 mg/L 3compartmentss NA 50% Human Human -DTXSID8046452 Css NA 6.427 mg/L 3compartmentss NA 95% Human Human -DTXSID8046452 Css NA 0.4578 mg/L PBTK NA 50% Human Human -DTXSID8046452 Css NA 3.908 mg/L PBTK NA 95% Human Human -DTXSID8046452 Clint NA 98.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046452 Fup NA 0.0068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046452 Vd NA 1.068 L/kg 1compartment NA NA Rat Human -DTXSID8046452 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046452 TK.Half.Life NA 2.794 hours 1compartment NA NA Rat Human -DTXSID8046452 Css NA 0.4171 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046452 Css NA 3.325 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046452 Css NA 0.242 mg/L PBTK NA 50% Rat Human -DTXSID8046452 Css NA 1.88 mg/L PBTK NA 95% Rat Human -DTXSID8046454 Clint NA 237.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8046406 TK.Half.Life NA 0.9491 hours 1compartment NA NA Rat Human +DTXSID8046406 Css NA 0.1116 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046406 Css NA 0.801 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046406 Css NA 0.06476 mg/L PBTK NA 50% Rat Human +DTXSID8046406 Css NA 0.4557 mg/L PBTK NA 95% Rat Human +DTXSID8046450 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046450 Fup 0.00873 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046450 Vd NA 24.81 L/kg 1compartment NA NA Human Human +DTXSID8046450 Days.Css NA 85 Days PBTK NA NA Human Human +DTXSID8046450 TK.Half.Life NA 395 hours 1compartment NA NA Human Human +DTXSID8046450 Css NA 0.731 mg/L 3compartmentss NA 50% Human Human +DTXSID8046450 Css NA 10.44 mg/L 3compartmentss NA 95% Human Human +DTXSID8046450 Css NA 1.669 mg/L PBTK NA 50% Human Human +DTXSID8046450 Css NA 14.16 mg/L PBTK NA 95% Human Human +DTXSID8046450 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046450 Fup 0.00873 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046450 Vd NA 20.33 L/kg 1compartment NA NA Rat Human +DTXSID8046450 Days.Css NA 52 Days PBTK NA NA Rat Human +DTXSID8046450 TK.Half.Life NA 152.3 hours 1compartment NA NA Rat Human +DTXSID8046450 Css NA 0.08639 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046450 Css NA 1.089 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046450 Css NA 0.2104 mg/L PBTK NA 50% Rat Human +DTXSID8046450 Css NA 1.401 mg/L PBTK NA 95% Rat Human +DTXSID8046452 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046452 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046452 Vd NA 8.547 L/kg 1compartment NA NA Human Human +DTXSID8046452 Days.Css NA 24 Days PBTK NA NA Human Human +DTXSID8046452 TK.Half.Life NA 142 hours 1compartment NA NA Human Human +DTXSID8046452 Css NA 1.552 mg/L 3compartmentss NA 50% Human Human +DTXSID8046452 Css NA 13.67 mg/L 3compartmentss NA 95% Human Human +DTXSID8046452 Css NA 1.589 mg/L PBTK NA 50% Human Human +DTXSID8046452 Css NA 11.68 mg/L PBTK NA 95% Human Human +DTXSID8046452 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046452 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046452 Vd NA 6.685 L/kg 1compartment NA NA Rat Human +DTXSID8046452 Days.Css NA 15 Days PBTK NA NA Rat Human +DTXSID8046452 TK.Half.Life NA 37.96 hours 1compartment NA NA Rat Human +DTXSID8046452 Css NA 0.1925 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046452 Css NA 1.45 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046452 Css NA 0.2042 mg/L PBTK NA 50% Rat Human +DTXSID8046452 Css NA 1.265 mg/L PBTK NA 95% Rat Human +DTXSID8046454 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID8046454 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8046454 Vd NA 1.537 L/kg 1compartment NA NA Human Human -DTXSID8046454 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046454 TK.Half.Life NA 1.726 hours 1compartment NA NA Human Human -DTXSID8046454 Css NA 0.0437 mg/L 3compartmentss NA 50% Human Human -DTXSID8046454 Css NA 0.3323 mg/L 3compartmentss NA 95% Human Human -DTXSID8046454 Css NA 0.02832 mg/L PBTK NA 50% Human Human -DTXSID8046454 Css NA 0.2041 mg/L PBTK NA 95% Human Human -DTXSID8046454 Clint NA 237.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8046454 Vd NA 1.248 L/kg 1compartment NA NA Human Human +DTXSID8046454 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046454 TK.Half.Life NA 14.32 hours 1compartment NA NA Human Human +DTXSID8046454 Css NA 1.7 mg/L 3compartmentss NA 50% Human Human +DTXSID8046454 Css NA 10.2 mg/L 3compartmentss NA 95% Human Human +DTXSID8046454 Css NA 1.088 mg/L PBTK NA 50% Human Human +DTXSID8046454 Css NA 6.302 mg/L PBTK NA 95% Human Human +DTXSID8046454 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID8046454 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8046454 Vd NA 1.164 L/kg 1compartment NA NA Rat Human +DTXSID8046454 Vd NA 0.953 L/kg 1compartment NA NA Rat Human DTXSID8046454 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046454 TK.Half.Life NA 0.6022 hours 1compartment NA NA Rat Human -DTXSID8046454 Css NA 0.02457 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046454 Css NA 0.1543 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046454 Css NA 0.01511 mg/L PBTK NA 50% Rat Human -DTXSID8046454 Css NA 0.09125 mg/L PBTK NA 95% Rat Human -DTXSID8046456 Clint NA 850.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046456 Fup NA 0.0398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046456 Vd NA 3.012 L/kg 1compartment NA NA Human Human -DTXSID8046456 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046456 TK.Half.Life NA 3.652 hours 1compartment NA NA Human Human -DTXSID8046456 Css NA 0.05166 mg/L 3compartmentss NA 50% Human Human -DTXSID8046456 Css NA 0.3405 mg/L 3compartmentss NA 95% Human Human -DTXSID8046456 Css NA 0.03562 mg/L PBTK NA 50% Human Human -DTXSID8046456 Css NA 0.226 mg/L PBTK NA 95% Human Human -DTXSID8046456 Clint NA 850.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046456 Fup NA 0.0398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046456 Vd NA 2.256 L/kg 1compartment NA NA Rat Human -DTXSID8046456 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046456 TK.Half.Life NA 0.9891 hours 1compartment NA NA Rat Human -DTXSID8046456 Css NA 0.02896 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046456 Css NA 0.156 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046456 Css NA 0.01904 mg/L PBTK NA 50% Rat Human -DTXSID8046456 Css NA 0.1011 mg/L PBTK NA 95% Rat Human -DTXSID8046458 Clint NA 29.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046458 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046458 Vd NA 1.876 L/kg 1compartment NA NA Human Human -DTXSID8046458 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046458 TK.Half.Life NA 10.32 hours 1compartment NA NA Human Human -DTXSID8046458 Css NA 0.7774 mg/L 3compartmentss NA 50% Human Human -DTXSID8046458 Css NA 7.297 mg/L 3compartmentss NA 95% Human Human -DTXSID8046458 Css NA 0.5094 mg/L PBTK NA 50% Human Human -DTXSID8046458 Css NA 4.523 mg/L PBTK NA 95% Human Human -DTXSID8046458 Clint NA 29.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046458 Fup NA 0.0104 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046458 Vd NA 1.479 L/kg 1compartment NA NA Rat Human +DTXSID8046454 TK.Half.Life NA 5.786 hours 1compartment NA NA Rat Human +DTXSID8046454 Css NA 0.2045 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046454 Css NA 0.918 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046454 Css NA 0.1278 mg/L PBTK NA 50% Rat Human +DTXSID8046454 Css NA 0.5362 mg/L PBTK NA 95% Rat Human +DTXSID8046456 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046456 Fup 0.0269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046456 Vd NA 2.921 L/kg 1compartment NA NA Human Human +DTXSID8046456 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8046456 TK.Half.Life NA 46.03 hours 1compartment NA NA Human Human +DTXSID8046456 Css NA 1.741 mg/L 3compartmentss NA 50% Human Human +DTXSID8046456 Css NA 12.59 mg/L 3compartmentss NA 95% Human Human +DTXSID8046456 Css NA 1.193 mg/L PBTK NA 50% Human Human +DTXSID8046456 Css NA 8.242 mg/L PBTK NA 95% Human Human +DTXSID8046456 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046456 Fup 0.0269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046456 Vd NA 2.186 L/kg 1compartment NA NA Rat Human +DTXSID8046456 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8046456 TK.Half.Life NA 8.077 hours 1compartment NA NA Rat Human +DTXSID8046456 Css NA 0.08764 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046456 Css NA 0.6083 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046456 Css NA 0.05834 mg/L PBTK NA 50% Rat Human +DTXSID8046456 Css NA 0.3832 mg/L PBTK NA 95% Rat Human +DTXSID8046458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046458 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046458 Vd NA 3.019 L/kg 1compartment NA NA Human Human +DTXSID8046458 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046458 TK.Half.Life NA 17.08 hours 1compartment NA NA Human Human +DTXSID8046458 Css NA 0.6344 mg/L 3compartmentss NA 50% Human Human +DTXSID8046458 Css NA 4.468 mg/L 3compartmentss NA 95% Human Human +DTXSID8046458 Css NA 0.4412 mg/L PBTK NA 50% Human Human +DTXSID8046458 Css NA 2.954 mg/L PBTK NA 95% Human Human +DTXSID8046458 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046458 Fup 0.0139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046458 Vd NA 2.295 L/kg 1compartment NA NA Rat Human DTXSID8046458 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046458 TK.Half.Life NA 4.077 hours 1compartment NA NA Rat Human -DTXSID8046458 Css NA 0.4426 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046458 Css NA 3.476 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046458 Css NA 0.2714 mg/L PBTK NA 50% Rat Human -DTXSID8046458 Css NA 2.022 mg/L PBTK NA 95% Rat Human -DTXSID8046531 Clint NA 0.7392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046531 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046531 Vd NA 0.9668 L/kg 1compartment NA NA Human Human +DTXSID8046458 TK.Half.Life NA 3.32 hours 1compartment NA NA Rat Human +DTXSID8046458 Css NA 0.08202 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046458 Css NA 0.5069 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046458 Css NA 0.05637 mg/L PBTK NA 50% Rat Human +DTXSID8046458 Css NA 0.3423 mg/L PBTK NA 95% Rat Human +DTXSID8046531 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046531 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046531 Vd NA 0.6731 L/kg 1compartment NA NA Human Human DTXSID8046531 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046531 TK.Half.Life NA 2.995 hours 1compartment NA NA Human Human -DTXSID8046531 Css NA 0.3603 mg/L 3compartmentss NA 50% Human Human -DTXSID8046531 Css NA 2.487 mg/L 3compartmentss NA 95% Human Human -DTXSID8046531 Css NA 0.3153 mg/L PBTK NA 50% Human Human -DTXSID8046531 Css NA 1.63 mg/L PBTK NA 95% Human Human -DTXSID8046531 Clint NA 0.7392 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046531 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046531 Vd NA 0.9768 L/kg 1compartment NA NA Rat Human +DTXSID8046531 TK.Half.Life NA 7.953 hours 1compartment NA NA Human Human +DTXSID8046531 Css NA 1.302 mg/L 3compartmentss NA 50% Human Human +DTXSID8046531 Css NA 8.289 mg/L 3compartmentss NA 95% Human Human +DTXSID8046531 Css NA 1.024 mg/L PBTK NA 50% Human Human +DTXSID8046531 Css NA 5.235 mg/L PBTK NA 95% Human Human +DTXSID8046531 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046531 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046531 Vd NA 0.6778 L/kg 1compartment NA NA Rat Human DTXSID8046531 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046531 TK.Half.Life NA 1.386 hours 1compartment NA NA Rat Human -DTXSID8046531 Css NA 0.1262 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046531 Css NA 0.8473 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046531 Css NA 0.1096 mg/L PBTK NA 50% Rat Human -DTXSID8046531 Css NA 0.5153 mg/L PBTK NA 95% Rat Human -DTXSID8046537 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046537 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046537 Vd NA 0.6447 L/kg 1compartment NA NA Human Human -DTXSID8046537 TK.Half.Life NA NA hours 1compartment NA NA Human Human -DTXSID8046537 Css NA NA mg/L 3compartmentss NA 50% Human Human -DTXSID8046537 Css NA NA mg/L 3compartmentss NA 95% Human Human -DTXSID8046537 Css NA NA mg/L PBTK NA 50% Human Human -DTXSID8046537 Css NA NA mg/L PBTK NA 95% Human Human -DTXSID8046537 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046537 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046537 Vd NA 0.7067 L/kg 1compartment NA NA Rat Human -DTXSID8046537 TK.Half.Life NA NA hours 1compartment NA NA Rat Human -DTXSID8046537 Css NA NA mg/L 3compartmentss NA 50% Rat Human -DTXSID8046537 Css NA NA mg/L 3compartmentss NA 95% Rat Human -DTXSID8046537 Css NA NA mg/L PBTK NA 50% Rat Human -DTXSID8046537 Css NA NA mg/L PBTK NA 95% Rat Human -DTXSID8046539 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046539 Fup NA 0.5643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046539 Vd NA 0.4024 L/kg 1compartment NA NA Human Human +DTXSID8046531 TK.Half.Life NA 2.72 hours 1compartment NA NA Rat Human +DTXSID8046531 Css NA 0.08009 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046531 Css NA 0.4796 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046531 Css NA 0.06246 mg/L PBTK NA 50% Rat Human +DTXSID8046531 Css NA 0.2909 mg/L PBTK NA 95% Rat Human +DTXSID8046539 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046539 Fup 0.828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046539 Vd NA 0.4746 L/kg 1compartment NA NA Human Human DTXSID8046539 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046539 TK.Half.Life NA 4.615 hours 1compartment NA NA Human Human -DTXSID8046539 Css NA 1.437 mg/L 3compartmentss NA 50% Human Human -DTXSID8046539 Css NA 9.204 mg/L 3compartmentss NA 95% Human Human -DTXSID8046539 Css NA 1.029 mg/L PBTK NA 50% Human Human -DTXSID8046539 Css NA 5.592 mg/L PBTK NA 95% Human Human -DTXSID8046539 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046539 Fup NA 0.5643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046539 Vd NA 0.4179 L/kg 1compartment NA NA Rat Human +DTXSID8046539 TK.Half.Life NA 3.709 hours 1compartment NA NA Human Human +DTXSID8046539 Css NA 0.9181 mg/L 3compartmentss NA 50% Human Human +DTXSID8046539 Css NA 5.236 mg/L 3compartmentss NA 95% Human Human +DTXSID8046539 Css NA 0.6857 mg/L PBTK NA 50% Human Human +DTXSID8046539 Css NA 3.265 mg/L PBTK NA 95% Human Human +DTXSID8046539 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046539 Fup 0.828 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046539 Vd NA 0.4973 L/kg 1compartment NA NA Rat Human DTXSID8046539 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046539 TK.Half.Life NA 1.633 hours 1compartment NA NA Rat Human -DTXSID8046539 Css NA 0.3822 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046539 Css NA 2.306 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046539 Css NA 0.26 mg/L PBTK NA 50% Rat Human -DTXSID8046539 Css NA 1.31 mg/L PBTK NA 95% Rat Human -DTXSID8046581 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046581 Fup NA 0.7382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046581 Vd NA 1.237 L/kg 1compartment NA NA Human Human -DTXSID8046581 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8046581 TK.Half.Life NA 11.66 hours 1compartment NA NA Human Human -DTXSID8046581 Css NA 0.9884 mg/L 3compartmentss NA 50% Human Human -DTXSID8046581 Css NA 6.808 mg/L 3compartmentss NA 95% Human Human -DTXSID8046581 Css NA 0.882 mg/L PBTK NA 50% Human Human -DTXSID8046581 Css NA 4.393 mg/L PBTK NA 95% Human Human -DTXSID8046581 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046581 Fup NA 0.7382 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046581 Vd NA 1.136 L/kg 1compartment NA NA Rat Human +DTXSID8046539 TK.Half.Life NA 1.324 hours 1compartment NA NA Rat Human +DTXSID8046539 Css NA 0.01722 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046539 Css NA 0.1209 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046539 Css NA 0.01226 mg/L PBTK NA 50% Rat Human +DTXSID8046539 Css NA 0.07617 mg/L PBTK NA 95% Rat Human +DTXSID8046581 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046581 Fup 0.503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046581 Vd NA 0.6898 L/kg 1compartment NA NA Human Human +DTXSID8046581 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8046581 TK.Half.Life NA 8.945 hours 1compartment NA NA Human Human +DTXSID8046581 Css NA 1.403 mg/L 3compartmentss NA 50% Human Human +DTXSID8046581 Css NA 7.398 mg/L 3compartmentss NA 95% Human Human +DTXSID8046581 Css NA 1.091 mg/L PBTK NA 50% Human Human +DTXSID8046581 Css NA 4.741 mg/L PBTK NA 95% Human Human +DTXSID8046581 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046581 Fup 0.503 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046581 Vd NA 0.6824 L/kg 1compartment NA NA Rat Human DTXSID8046581 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046581 TK.Half.Life NA 3.454 hours 1compartment NA NA Rat Human -DTXSID8046581 Css NA 0.2594 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046581 Css NA 1.723 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046581 Css NA 0.2244 mg/L PBTK NA 50% Rat Human -DTXSID8046581 Css NA 1.05 mg/L PBTK NA 95% Rat Human -DTXSID8046583 Clint NA 0.002996 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046583 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046583 Vd NA 0.6447 L/kg 1compartment NA NA Human Human -DTXSID8046583 TK.Half.Life NA NA hours 1compartment NA NA Human Human -DTXSID8046583 Css NA NA mg/L 3compartmentss NA 50% Human Human -DTXSID8046583 Css NA NA mg/L 3compartmentss NA 95% Human Human -DTXSID8046583 Css NA NA mg/L PBTK NA 50% Human Human -DTXSID8046583 Css NA NA mg/L PBTK NA 95% Human Human -DTXSID8046583 Clint NA 0.002996 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046583 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046583 Vd NA 0.7067 L/kg 1compartment NA NA Rat Human -DTXSID8046583 TK.Half.Life NA NA hours 1compartment NA NA Rat Human -DTXSID8046583 Css NA NA mg/L 3compartmentss NA 50% Rat Human -DTXSID8046583 Css NA NA mg/L 3compartmentss NA 95% Rat Human -DTXSID8046583 Css NA NA mg/L PBTK NA 50% Rat Human -DTXSID8046583 Css NA NA mg/L PBTK NA 95% Rat Human -DTXSID8046585 Clint NA 7.509 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046585 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046585 Vd NA 0.1922 L/kg 1compartment NA NA Human Human +DTXSID8046581 TK.Half.Life NA 2.998 hours 1compartment NA NA Rat Human +DTXSID8046581 Css NA 0.08676 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046581 Css NA 0.415 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046581 Css NA 0.06709 mg/L PBTK NA 50% Rat Human +DTXSID8046581 Css NA 0.2557 mg/L PBTK NA 95% Rat Human +DTXSID8046585 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046585 Fup 0.0484 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046585 Vd NA 0.2675 L/kg 1compartment NA NA Human Human DTXSID8046585 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046585 TK.Half.Life NA 6.911 hours 1compartment NA NA Human Human -DTXSID8046585 Css NA 6.732 mg/L 3compartmentss NA 50% Human Human -DTXSID8046585 Css NA 55.97 mg/L 3compartmentss NA 95% Human Human -DTXSID8046585 Css NA 3.968 mg/L PBTK NA 50% Human Human -DTXSID8046585 Css NA 32.48 mg/L PBTK NA 95% Human Human -DTXSID8046585 Clint NA 7.509 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046585 Fup NA 0.0137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046585 Vd NA 0.1879 L/kg 1compartment NA NA Rat Human +DTXSID8046585 TK.Half.Life NA 1.203 hours 1compartment NA NA Human Human +DTXSID8046585 Css NA 0.6387 mg/L 3compartmentss NA 50% Human Human +DTXSID8046585 Css NA 5.572 mg/L 3compartmentss NA 95% Human Human +DTXSID8046585 Css NA 0.3896 mg/L PBTK NA 50% Human Human +DTXSID8046585 Css NA 3.282 mg/L PBTK NA 95% Human Human +DTXSID8046585 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046585 Fup 0.0484 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046585 Vd NA 0.26 L/kg 1compartment NA NA Rat Human DTXSID8046585 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046585 TK.Half.Life NA 4.354 hours 1compartment NA NA Rat Human -DTXSID8046585 Css NA 3.598 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046585 Css NA 24.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046585 Css NA 1.969 mg/L PBTK NA 50% Rat Human -DTXSID8046585 Css NA 13.48 mg/L PBTK NA 95% Rat Human -DTXSID8046589 Clint NA 4.978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046589 Fup NA 0.0598 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046589 Vd NA 3.073 L/kg 1compartment NA NA Human Human -DTXSID8046589 Days.Css NA 45 Days PBTK NA NA Human Human -DTXSID8046589 TK.Half.Life NA 219.9 hours 1compartment NA NA Human Human -DTXSID8046589 Css NA 8.868 mg/L 3compartmentss NA 50% Human Human -DTXSID8046589 Css NA 51.81 mg/L 3compartmentss NA 95% Human Human -DTXSID8046589 Css NA 6.159 mg/L PBTK NA 50% Human Human -DTXSID8046589 Css NA 35.49 mg/L PBTK NA 95% Human Human -DTXSID8046589 Clint NA 4.978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046589 Fup NA 0.0598 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046589 Vd NA 2.303 L/kg 1compartment NA NA Rat Human -DTXSID8046589 Days.Css NA 24 Days PBTK NA NA Rat Human -DTXSID8046589 TK.Half.Life NA 30.31 hours 1compartment NA NA Rat Human -DTXSID8046589 Css NA 4.888 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046589 Css NA 22.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046589 Css NA 3.258 mg/L PBTK NA 50% Rat Human -DTXSID8046589 Css NA 14.85 mg/L PBTK NA 95% Rat Human -DTXSID8046610 Clint NA 2.408 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046610 Fup NA 0.2851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046610 Vd NA 2.682 L/kg 1compartment NA NA Human Human -DTXSID8046610 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8046610 TK.Half.Life NA 28.34 hours 1compartment NA NA Human Human -DTXSID8046610 Css NA 1.102 mg/L 3compartmentss NA 50% Human Human -DTXSID8046610 Css NA 4.867 mg/L 3compartmentss NA 95% Human Human -DTXSID8046610 Css NA 0.8644 mg/L PBTK NA 50% Human Human -DTXSID8046610 Css NA 3.497 mg/L PBTK NA 95% Human Human -DTXSID8046610 Clint NA 2.408 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046610 Fup NA 0.2851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046610 Vd NA 2.133 L/kg 1compartment NA NA Rat Human -DTXSID8046610 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8046610 TK.Half.Life NA 7.081 hours 1compartment NA NA Rat Human -DTXSID8046610 Css NA 0.5238 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046610 Css NA 1.598 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046610 Css NA 0.3962 mg/L PBTK NA 50% Rat Human -DTXSID8046610 Css NA 1.079 mg/L PBTK NA 95% Rat Human -DTXSID8046618 Clint NA 17.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046618 Fup NA 0.3528 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046618 Vd NA 0.514 L/kg 1compartment NA NA Human Human +DTXSID8046585 TK.Half.Life NA 0.7362 hours 1compartment NA NA Rat Human +DTXSID8046585 Css NA 0.08477 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046585 Css NA 0.5547 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046585 Css NA 0.04991 mg/L PBTK NA 50% Rat Human +DTXSID8046585 Css NA 0.3185 mg/L PBTK NA 95% Rat Human +DTXSID8046589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046589 Fup 0.0167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046589 Vd NA 2.922 L/kg 1compartment NA NA Human Human +DTXSID8046589 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID8046589 TK.Half.Life NA 55.85 hours 1compartment NA NA Human Human +DTXSID8046589 Css NA 2.136 mg/L 3compartmentss NA 50% Human Human +DTXSID8046589 Css NA 14.89 mg/L 3compartmentss NA 95% Human Human +DTXSID8046589 Css NA 1.457 mg/L PBTK NA 50% Human Human +DTXSID8046589 Css NA 9.928 mg/L PBTK NA 95% Human Human +DTXSID8046589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046589 Fup 0.0167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046589 Vd NA 2.186 L/kg 1compartment NA NA Rat Human +DTXSID8046589 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID8046589 TK.Half.Life NA 9.682 hours 1compartment NA NA Rat Human +DTXSID8046589 Css NA 0.1096 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046589 Css NA 0.7509 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046589 Css NA 0.0729 mg/L PBTK NA 50% Rat Human +DTXSID8046589 Css NA 0.4756 mg/L PBTK NA 95% Rat Human +DTXSID8046610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046610 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046610 Vd NA 2.129 L/kg 1compartment NA NA Human Human +DTXSID8046610 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8046610 TK.Half.Life NA 2.849 hours 1compartment NA NA Human Human +DTXSID8046610 Css NA 0.07181 mg/L 3compartmentss NA 50% Human Human +DTXSID8046610 Css NA 0.5338 mg/L 3compartmentss NA 95% Human Human +DTXSID8046610 Css NA 0.05896 mg/L PBTK NA 50% Human Human +DTXSID8046610 Css NA 0.3946 mg/L PBTK NA 95% Human Human +DTXSID8046610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046610 Fup 0.333 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046610 Vd NA 1.789 L/kg 1compartment NA NA Rat Human +DTXSID8046610 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8046610 TK.Half.Life NA 1.115 hours 1compartment NA NA Rat Human +DTXSID8046610 Css NA 0.009018 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046610 Css NA 0.05092 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046610 Css NA 0.007395 mg/L PBTK NA 50% Rat Human +DTXSID8046610 Css NA 0.03723 mg/L PBTK NA 95% Rat Human +DTXSID8046618 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046618 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046618 Vd NA 0.5903 L/kg 1compartment NA NA Human Human DTXSID8046618 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046618 TK.Half.Life NA 0.6816 hours 1compartment NA NA Human Human -DTXSID8046618 Css NA 0.07614 mg/L 3compartmentss NA 50% Human Human -DTXSID8046618 Css NA 0.5458 mg/L 3compartmentss NA 95% Human Human -DTXSID8046618 Css NA 0.05411 mg/L PBTK NA 50% Human Human -DTXSID8046618 Css NA 0.3612 mg/L PBTK NA 95% Human Human -DTXSID8046618 Clint NA 17.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046618 Fup NA 0.3528 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046618 Vd NA 0.5174 L/kg 1compartment NA NA Rat Human +DTXSID8046618 TK.Half.Life NA 5.311 hours 1compartment NA NA Human Human +DTXSID8046618 Css NA 0.9346 mg/L 3compartmentss NA 50% Human Human +DTXSID8046618 Css NA 6.005 mg/L 3compartmentss NA 95% Human Human +DTXSID8046618 Css NA 0.7352 mg/L PBTK NA 50% Human Human +DTXSID8046618 Css NA 3.789 mg/L PBTK NA 95% Human Human +DTXSID8046618 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046618 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046618 Vd NA 0.6227 L/kg 1compartment NA NA Rat Human DTXSID8046618 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046618 TK.Half.Life NA 0.3642 hours 1compartment NA NA Rat Human -DTXSID8046618 Css NA 0.04039 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046618 Css NA 0.226 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046618 Css NA 0.02767 mg/L PBTK NA 50% Rat Human -DTXSID8046618 Css NA 0.1408 mg/L PBTK NA 95% Rat Human -DTXSID8046660 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046660 Fup NA 0.3692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046660 Vd NA 0.3219 L/kg 1compartment NA NA Human Human +DTXSID8046618 TK.Half.Life NA 1.91 hours 1compartment NA NA Rat Human +DTXSID8046618 Css NA 0.01789 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046618 Css NA 0.1476 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046618 Css NA 0.01354 mg/L PBTK NA 50% Rat Human +DTXSID8046618 Css NA 0.09281 mg/L PBTK NA 95% Rat Human +DTXSID8046660 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046660 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046660 Vd NA 0.2844 L/kg 1compartment NA NA Human Human DTXSID8046660 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046660 TK.Half.Life NA 5.64 hours 1compartment NA NA Human Human -DTXSID8046660 Css NA 2.159 mg/L 3compartmentss NA 50% Human Human -DTXSID8046660 Css NA 8.548 mg/L 3compartmentss NA 95% Human Human -DTXSID8046660 Css NA 1.448 mg/L PBTK NA 50% Human Human -DTXSID8046660 Css NA 5.255 mg/L PBTK NA 95% Human Human -DTXSID8046660 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046660 Fup NA 0.3692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046660 Vd NA 0.3327 L/kg 1compartment NA NA Rat Human +DTXSID8046660 TK.Half.Life NA 6.843 hours 1compartment NA NA Human Human +DTXSID8046660 Css NA 1.613 mg/L 3compartmentss NA 50% Human Human +DTXSID8046660 Css NA 6.437 mg/L 3compartmentss NA 95% Human Human +DTXSID8046660 Css NA 1.043 mg/L PBTK NA 50% Human Human +DTXSID8046660 Css NA 3.907 mg/L PBTK NA 95% Human Human +DTXSID8046660 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046660 Fup 0.269 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046660 Vd NA 0.2965 L/kg 1compartment NA NA Rat Human DTXSID8046660 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046660 TK.Half.Life NA 1.986 hours 1compartment NA NA Rat Human -DTXSID8046660 Css NA 0.6003 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046660 Css NA 1.988 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046660 Css NA 0.3792 mg/L PBTK NA 50% Rat Human -DTXSID8046660 Css NA 1.135 mg/L PBTK NA 95% Rat Human -DTXSID8046662 Clint NA 22.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046662 Fup NA 0.0719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046662 Vd NA 2.459 L/kg 1compartment NA NA Human Human +DTXSID8046660 TK.Half.Life NA 2.43 hours 1compartment NA NA Rat Human +DTXSID8046660 Css NA 0.008822 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046660 Css NA 0.03652 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046660 Css NA 0.005413 mg/L PBTK NA 50% Rat Human +DTXSID8046660 Css NA 0.02118 mg/L PBTK NA 95% Rat Human +DTXSID8046662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046662 Fup 0.0648 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046662 Vd NA 2.1 L/kg 1compartment NA NA Human Human DTXSID8046662 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046662 TK.Half.Life NA 12.14 hours 1compartment NA NA Human Human -DTXSID8046662 Css NA 0.5965 mg/L 3compartmentss NA 50% Human Human -DTXSID8046662 Css NA 4.124 mg/L 3compartmentss NA 95% Human Human -DTXSID8046662 Css NA 0.4062 mg/L PBTK NA 50% Human Human -DTXSID8046662 Css NA 2.679 mg/L PBTK NA 95% Human Human -DTXSID8046662 Clint NA 22.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046662 Fup NA 0.0719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046662 Vd NA 1.872 L/kg 1compartment NA NA Rat Human +DTXSID8046662 TK.Half.Life NA 9.963 hours 1compartment NA NA Human Human +DTXSID8046662 Css NA 0.5695 mg/L 3compartmentss NA 50% Human Human +DTXSID8046662 Css NA 3.787 mg/L 3compartmentss NA 95% Human Human +DTXSID8046662 Css NA 0.3781 mg/L PBTK NA 50% Human Human +DTXSID8046662 Css NA 2.445 mg/L PBTK NA 95% Human Human +DTXSID8046662 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046662 Fup 0.0648 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046662 Vd NA 1.574 L/kg 1compartment NA NA Rat Human DTXSID8046662 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046662 TK.Half.Life NA 3.383 hours 1compartment NA NA Rat Human -DTXSID8046662 Css NA 0.3304 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046662 Css NA 1.708 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046662 Css NA 0.215 mg/L PBTK NA 50% Rat Human -DTXSID8046662 Css NA 1.059 mg/L PBTK NA 95% Rat Human -DTXSID8046664 Clint NA 0.7467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046664 Fup NA 0.9269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046664 Vd NA 0.9683 L/kg 1compartment NA NA Human Human +DTXSID8046662 TK.Half.Life NA 3.107 hours 1compartment NA NA Rat Human +DTXSID8046662 Css NA 0.07383 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046662 Css NA 0.4038 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046662 Css NA 0.04844 mg/L PBTK NA 50% Rat Human +DTXSID8046662 Css NA 0.2562 mg/L PBTK NA 95% Rat Human +DTXSID8046664 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046664 Fup 0.443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046664 Vd NA 0.5696 L/kg 1compartment NA NA Human Human DTXSID8046664 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046664 TK.Half.Life NA 3.206 hours 1compartment NA NA Human Human -DTXSID8046664 Css NA 0.3736 mg/L 3compartmentss NA 50% Human Human -DTXSID8046664 Css NA 1.508 mg/L 3compartmentss NA 95% Human Human -DTXSID8046664 Css NA 0.3234 mg/L PBTK NA 50% Human Human -DTXSID8046664 Css NA 1.078 mg/L PBTK NA 95% Human Human -DTXSID8046664 Clint NA 0.7467 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046664 Fup NA 0.9269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046664 Vd NA 0.9791 L/kg 1compartment NA NA Rat Human +DTXSID8046664 TK.Half.Life NA 8.328 hours 1compartment NA NA Human Human +DTXSID8046664 Css NA 1.589 mg/L 3compartmentss NA 50% Human Human +DTXSID8046664 Css NA 7.277 mg/L 3compartmentss NA 95% Human Human +DTXSID8046664 Css NA 1.182 mg/L PBTK NA 50% Human Human +DTXSID8046664 Css NA 4.623 mg/L PBTK NA 95% Human Human +DTXSID8046664 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046664 Fup 0.443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046664 Vd NA 0.5821 L/kg 1compartment NA NA Rat Human DTXSID8046664 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046664 TK.Half.Life NA 1.492 hours 1compartment NA NA Rat Human -DTXSID8046664 Css NA 0.1334 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046664 Css NA 0.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046664 Css NA 0.1148 mg/L PBTK NA 50% Rat Human -DTXSID8046664 Css NA 0.3176 mg/L PBTK NA 95% Rat Human -DTXSID8046666 Clint NA 20.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046666 Fup NA 0.0972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046666 Vd NA 3.435 L/kg 1compartment NA NA Human Human -DTXSID8046666 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046666 TK.Half.Life NA 8.461 hours 1compartment NA NA Human Human -DTXSID8046666 Css NA 0.2133 mg/L 3compartmentss NA 50% Human Human -DTXSID8046666 Css NA 1.499 mg/L 3compartmentss NA 95% Human Human -DTXSID8046666 Css NA 0.1743 mg/L PBTK NA 50% Human Human -DTXSID8046666 Css NA 1.131 mg/L PBTK NA 95% Human Human -DTXSID8046666 Clint NA 20.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046666 Fup NA 0.0972 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046666 Vd NA 2.892 L/kg 1compartment NA NA Rat Human -DTXSID8046666 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046666 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human -DTXSID8046666 Css NA 0.1166 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046666 Css NA 0.651 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046666 Css NA 0.09229 mg/L PBTK NA 50% Rat Human -DTXSID8046666 Css NA 0.477 mg/L PBTK NA 95% Rat Human -DTXSID8046743 Clint NA 9.653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046743 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046743 Vd NA 2.841 L/kg 1compartment NA NA Human Human -DTXSID8046743 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID8046743 TK.Half.Life NA 58.99 hours 1compartment NA NA Human Human -DTXSID8046743 Css NA 2.697 mg/L 3compartmentss NA 50% Human Human -DTXSID8046743 Css NA 16.75 mg/L 3compartmentss NA 95% Human Human -DTXSID8046743 Css NA 1.856 mg/L PBTK NA 50% Human Human -DTXSID8046743 Css NA 11.1 mg/L PBTK NA 95% Human Human -DTXSID8046743 Clint NA 9.653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046743 Fup NA 0.0527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046743 Vd NA 2.132 L/kg 1compartment NA NA Rat Human -DTXSID8046743 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID8046743 TK.Half.Life NA 11.04 hours 1compartment NA NA Rat Human -DTXSID8046743 Css NA 1.474 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046743 Css NA 6.998 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046743 Css NA 0.9668 mg/L PBTK NA 50% Rat Human -DTXSID8046743 Css NA 4.458 mg/L PBTK NA 95% Rat Human -DTXSID8046749 Clint NA 12.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046749 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046749 Vd NA 5893 L/kg 1compartment NA NA Human Human -DTXSID8046749 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID8046749 TK.Half.Life NA 300300 hours 1compartment NA NA Human Human -DTXSID8046749 Css NA 0.004022 mg/L 3compartmentss NA 50% Human Human -DTXSID8046749 Css NA 0.02362 mg/L 3compartmentss NA 95% Human Human -DTXSID8046749 Css NA 4.277 mg/L PBTK NA 50% Human Human -DTXSID8046749 Css NA 23.53 mg/L PBTK NA 95% Human Human -DTXSID8046749 Clint NA 12.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046749 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046749 Vd NA 5521 L/kg 1compartment NA NA Rat Human +DTXSID8046664 TK.Half.Life NA 2.899 hours 1compartment NA NA Rat Human +DTXSID8046664 Css NA 0.1019 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046664 Css NA 0.3944 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046664 Css NA 0.07489 mg/L PBTK NA 50% Rat Human +DTXSID8046664 Css NA 0.2418 mg/L PBTK NA 95% Rat Human +DTXSID8046743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046743 Fup 0.0436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046743 Vd NA 2.723 L/kg 1compartment NA NA Human Human +DTXSID8046743 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8046743 TK.Half.Life NA 25.66 hours 1compartment NA NA Human Human +DTXSID8046743 Css NA 1.173 mg/L 3compartmentss NA 50% Human Human +DTXSID8046743 Css NA 8.131 mg/L 3compartmentss NA 95% Human Human +DTXSID8046743 Css NA 0.7976 mg/L PBTK NA 50% Human Human +DTXSID8046743 Css NA 5.383 mg/L PBTK NA 95% Human Human +DTXSID8046743 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046743 Fup 0.0436 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046743 Vd NA 2.042 L/kg 1compartment NA NA Rat Human +DTXSID8046743 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8046743 TK.Half.Life NA 5.541 hours 1compartment NA NA Rat Human +DTXSID8046743 Css NA 0.1518 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046743 Css NA 0.8668 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046743 Css NA 0.1018 mg/L PBTK NA 50% Rat Human +DTXSID8046743 Css NA 0.5724 mg/L PBTK NA 95% Rat Human +DTXSID8046749 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046749 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046749 Vd NA 14.01 L/kg 1compartment NA NA Human Human +DTXSID8046749 Days.Css NA 13780 Days PBTK NA NA Human Human +DTXSID8046749 TK.Half.Life NA 667100 hours 1compartment NA NA Human Human +DTXSID8046749 Css NA 2314 mg/L 3compartmentss NA 50% Human Human +DTXSID8046749 Css NA 5630 mg/L 3compartmentss NA 95% Human Human +DTXSID8046749 Css NA 3576 mg/L PBTK NA 50% Human Human +DTXSID8046749 Css NA 7702 mg/L PBTK NA 95% Human Human +DTXSID8046749 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046749 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046749 Vd NA 11.2 L/kg 1compartment NA NA Rat Human DTXSID8046749 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID8046749 TK.Half.Life NA 51730 hours 1compartment NA NA Rat Human -DTXSID8046749 Css NA 0.002036 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046749 Css NA 0.008618 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046749 Css NA 2.296 mg/L PBTK NA 50% Rat Human -DTXSID8046749 Css NA 9.937 mg/L PBTK NA 95% Rat Human -DTXSID8046791 Clint NA 42.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046791 Fup NA 0.0476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046791 Vd NA 2.579 L/kg 1compartment NA NA Human Human -DTXSID8046791 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046791 TK.Half.Life NA 11.36 hours 1compartment NA NA Human Human -DTXSID8046791 Css NA 0.5132 mg/L 3compartmentss NA 50% Human Human -DTXSID8046791 Css NA 3.582 mg/L 3compartmentss NA 95% Human Human -DTXSID8046791 Css NA 0.3464 mg/L PBTK NA 50% Human Human -DTXSID8046791 Css NA 2.34 mg/L PBTK NA 95% Human Human -DTXSID8046791 Clint NA 42.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046791 Fup NA 0.0476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046791 Vd NA 1.931 L/kg 1compartment NA NA Rat Human -DTXSID8046791 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046791 TK.Half.Life NA 2.833 hours 1compartment NA NA Rat Human -DTXSID8046791 Css NA 0.292 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046791 Css NA 1.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046791 Css NA 0.1871 mg/L PBTK NA 50% Rat Human -DTXSID8046791 Css NA 0.9864 mg/L PBTK NA 95% Rat Human +DTXSID8046749 TK.Half.Life NA 45070 hours 1compartment NA NA Rat Human +DTXSID8046749 Css NA 138.9 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046749 Css NA 227.2 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046749 Css NA 229.4 mg/L PBTK NA 50% Rat Human +DTXSID8046749 Css NA 311.1 mg/L PBTK NA 95% Rat Human +DTXSID8046791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046791 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046791 Vd NA 2.493 L/kg 1compartment NA NA Human Human +DTXSID8046791 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8046791 TK.Half.Life NA 22.53 hours 1compartment NA NA Human Human +DTXSID8046791 Css NA 1.187 mg/L 3compartmentss NA 50% Human Human +DTXSID8046791 Css NA 8.046 mg/L 3compartmentss NA 95% Human Human +DTXSID8046791 Css NA 0.7891 mg/L PBTK NA 50% Human Human +DTXSID8046791 Css NA 5.175 mg/L PBTK NA 95% Human Human +DTXSID8046791 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046791 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046791 Vd NA 1.864 L/kg 1compartment NA NA Rat Human +DTXSID8046791 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8046791 TK.Half.Life NA 5.668 hours 1compartment NA NA Rat Human +DTXSID8046791 Css NA 0.1566 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046791 Css NA 0.8465 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046791 Css NA 0.1022 mg/L PBTK NA 50% Rat Human +DTXSID8046791 Css NA 0.5443 mg/L PBTK NA 95% Rat Human DTXSID8046793 Clint NA 216.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8046793 Fup NA 0.3251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046793 Vd NA 2.55 L/kg 1compartment NA NA Human Human +DTXSID8046793 Vd NA 0.3307 L/kg 1compartment NA NA Human Human DTXSID8046793 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046793 TK.Half.Life NA 1.317 hours 1compartment NA NA Human Human -DTXSID8046793 Css NA 0.00385 mg/L 3compartmentss NA 50% Human Human -DTXSID8046793 Css NA 0.03524 mg/L 3compartmentss NA 95% Human Human -DTXSID8046793 Css NA 0.004322 mg/L PBTK NA 50% Human Human -DTXSID8046793 Css NA 0.03189 mg/L PBTK NA 95% Human Human +DTXSID8046793 TK.Half.Life NA 0.2891 hours 1compartment NA NA Human Human +DTXSID8046793 Css NA 0.003133 mg/L 3compartmentss NA 50% Human Human +DTXSID8046793 Css NA 0.0431 mg/L 3compartmentss NA 95% Human Human +DTXSID8046793 Css NA 0.002048 mg/L PBTK NA 50% Human Human +DTXSID8046793 Css NA 0.02732 mg/L PBTK NA 95% Human Human DTXSID8046793 Clint NA 216.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8046793 Fup NA 0.3251 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046793 Vd NA 2.515 L/kg 1compartment NA NA Rat Human +DTXSID8046793 Vd NA 0.3475 L/kg 1compartment NA NA Rat Human DTXSID8046793 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046793 TK.Half.Life NA 0.596 hours 1compartment NA NA Rat Human -DTXSID8046793 Css NA 0.002036 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046793 Css NA 0.01607 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046793 Css NA 0.002304 mg/L PBTK NA 50% Rat Human -DTXSID8046793 Css NA 0.01426 mg/L PBTK NA 95% Rat Human -DTXSID8046795 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046795 Fup NA 0.9183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046795 Vd NA 0.9429 L/kg 1compartment NA NA Human Human +DTXSID8046793 TK.Half.Life NA 0.136 hours 1compartment NA NA Rat Human +DTXSID8046793 Css NA 0.0001019 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046793 Css NA 0.001757 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046793 Css NA 6.543e-05 mg/L PBTK NA 50% Rat Human +DTXSID8046793 Css NA 0.001069 mg/L PBTK NA 95% Rat Human +DTXSID8046795 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046795 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046795 Vd NA 0.429 L/kg 1compartment NA NA Human Human DTXSID8046795 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046795 TK.Half.Life NA 6.71 hours 1compartment NA NA Human Human -DTXSID8046795 Css NA 0.849 mg/L 3compartmentss NA 50% Human Human -DTXSID8046795 Css NA 3.214 mg/L 3compartmentss NA 95% Human Human -DTXSID8046795 Css NA 0.7356 mg/L PBTK NA 50% Human Human -DTXSID8046795 Css NA 2.275 mg/L PBTK NA 95% Human Human -DTXSID8046795 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046795 Fup NA 0.9183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046795 Vd NA 0.9437 L/kg 1compartment NA NA Rat Human +DTXSID8046795 TK.Half.Life NA 7.733 hours 1compartment NA NA Human Human +DTXSID8046795 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human +DTXSID8046795 Css NA 4.97 mg/L 3compartmentss NA 95% Human Human +DTXSID8046795 Css NA 0.7963 mg/L PBTK NA 50% Human Human +DTXSID8046795 Css NA 3.103 mg/L PBTK NA 95% Human Human +DTXSID8046795 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046795 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046795 Vd NA 0.4463 L/kg 1compartment NA NA Rat Human DTXSID8046795 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046795 TK.Half.Life NA 2.271 hours 1compartment NA NA Rat Human -DTXSID8046795 Css NA 0.2175 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046795 Css NA 0.7818 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046795 Css NA 0.1846 mg/L PBTK NA 50% Rat Human -DTXSID8046795 Css NA 0.5096 mg/L PBTK NA 95% Rat Human -DTXSID8046799 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046799 Fup NA 0.3216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046799 Vd NA 0.3803 L/kg 1compartment NA NA Human Human +DTXSID8046795 TK.Half.Life NA 2.74 hours 1compartment NA NA Rat Human +DTXSID8046795 Css NA 0.006097 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046795 Css NA 0.02713 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046795 Css NA 0.004068 mg/L PBTK NA 50% Rat Human +DTXSID8046795 Css NA 0.01624 mg/L PBTK NA 95% Rat Human +DTXSID8046799 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046799 Fup 0.567 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046799 Vd NA 0.5027 L/kg 1compartment NA NA Human Human DTXSID8046799 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046799 TK.Half.Life NA 7.661 hours 1compartment NA NA Human Human -DTXSID8046799 Css NA 2.456 mg/L 3compartmentss NA 50% Human Human -DTXSID8046799 Css NA 9.605 mg/L 3compartmentss NA 95% Human Human -DTXSID8046799 Css NA 1.658 mg/L PBTK NA 50% Human Human -DTXSID8046799 Css NA 5.894 mg/L PBTK NA 95% Human Human -DTXSID8046799 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046799 Fup NA 0.3216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046799 Vd NA 0.3832 L/kg 1compartment NA NA Rat Human +DTXSID8046799 TK.Half.Life NA 5.747 hours 1compartment NA NA Human Human +DTXSID8046799 Css NA 1.343 mg/L 3compartmentss NA 50% Human Human +DTXSID8046799 Css NA 9.209 mg/L 3compartmentss NA 95% Human Human +DTXSID8046799 Css NA 0.9902 mg/L PBTK NA 50% Human Human +DTXSID8046799 Css NA 5.648 mg/L PBTK NA 95% Human Human +DTXSID8046799 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046799 Fup 0.567 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046799 Vd NA 0.5095 L/kg 1compartment NA NA Rat Human DTXSID8046799 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046799 TK.Half.Life NA 2.628 hours 1compartment NA NA Rat Human -DTXSID8046799 Css NA 0.68 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046799 Css NA 2.252 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046799 Css NA 0.434 mg/L PBTK NA 50% Rat Human -DTXSID8046799 Css NA 1.291 mg/L PBTK NA 95% Rat Human -DTXSID8046820 Clint NA 31.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046820 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046820 Vd NA 24.41 L/kg 1compartment NA NA Human Human -DTXSID8046820 Days.Css NA 112 Days PBTK NA NA Human Human -DTXSID8046820 TK.Half.Life NA 502.3 hours 1compartment NA NA Human Human -DTXSID8046820 Css NA 0.6526 mg/L 3compartmentss NA 50% Human Human -DTXSID8046820 Css NA 4.043 mg/L 3compartmentss NA 95% Human Human -DTXSID8046820 Css NA 1.67 mg/L PBTK NA 50% Human Human -DTXSID8046820 Css NA 9.62 mg/L PBTK NA 95% Human Human -DTXSID8046820 Clint NA 31.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046820 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046820 Vd NA 19.97 L/kg 1compartment NA NA Rat Human -DTXSID8046820 Days.Css NA 70 Days PBTK NA NA Rat Human -DTXSID8046820 TK.Half.Life NA 72.82 hours 1compartment NA NA Rat Human -DTXSID8046820 Css NA 0.3442 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046820 Css NA 1.481 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046820 Css NA 0.9192 mg/L PBTK NA 50% Rat Human -DTXSID8046820 Css NA 3.883 mg/L PBTK NA 95% Rat Human -DTXSID8046822 Clint NA 13.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046822 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046822 Vd NA 2.746 L/kg 1compartment NA NA Human Human -DTXSID8046822 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID8046822 TK.Half.Life NA 70.76 hours 1compartment NA NA Human Human -DTXSID8046822 Css NA 3.568 mg/L 3compartmentss NA 50% Human Human -DTXSID8046822 Css NA 24.3 mg/L 3compartmentss NA 95% Human Human -DTXSID8046822 Css NA 2.414 mg/L PBTK NA 50% Human Human -DTXSID8046822 Css NA 15.64 mg/L PBTK NA 95% Human Human -DTXSID8046822 Clint NA 13.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046822 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046822 Vd NA 2.051 L/kg 1compartment NA NA Rat Human -DTXSID8046822 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID8046822 TK.Half.Life NA 14.27 hours 1compartment NA NA Rat Human -DTXSID8046822 Css NA 2.022 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046822 Css NA 11.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046822 Css NA 1.294 mg/L PBTK NA 50% Rat Human -DTXSID8046822 Css NA 6.791 mg/L PBTK NA 95% Rat Human +DTXSID8046799 TK.Half.Life NA 1.982 hours 1compartment NA NA Rat Human +DTXSID8046799 Css NA 0.0835 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046799 Css NA 0.4985 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046799 Css NA 0.0607 mg/L PBTK NA 50% Rat Human +DTXSID8046799 Css NA 0.2961 mg/L PBTK NA 95% Rat Human +DTXSID8046822 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046822 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046822 Vd NA 2.496 L/kg 1compartment NA NA Human Human +DTXSID8046822 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8046822 TK.Half.Life NA 32.82 hours 1compartment NA NA Human Human +DTXSID8046822 Css NA 1.83 mg/L 3compartmentss NA 50% Human Human +DTXSID8046822 Css NA 13.57 mg/L 3compartmentss NA 95% Human Human +DTXSID8046822 Css NA 1.212 mg/L PBTK NA 50% Human Human +DTXSID8046822 Css NA 8.633 mg/L PBTK NA 95% Human Human +DTXSID8046822 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046822 Fup 0.018 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046822 Vd NA 1.861 L/kg 1compartment NA NA Rat Human +DTXSID8046822 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8046822 TK.Half.Life NA 8.113 hours 1compartment NA NA Rat Human +DTXSID8046822 Css NA 0.2347 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046822 Css NA 1.47 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046822 Css NA 0.1523 mg/L PBTK NA 50% Rat Human +DTXSID8046822 Css NA 0.9117 mg/L PBTK NA 95% Rat Human DTXSID8046824 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8046824 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046824 Vd NA 1.464 L/kg 1compartment NA NA Human Human +DTXSID8046824 Vd NA 1.554 L/kg 1compartment NA NA Human Human DTXSID8046824 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8046824 TK.Half.Life NA 10.4 hours 1compartment NA NA Human Human -DTXSID8046824 Css NA 0.7346 mg/L 3compartmentss NA 50% Human Human -DTXSID8046824 Css NA 5.487 mg/L 3compartmentss NA 95% Human Human -DTXSID8046824 Css NA 0.7082 mg/L PBTK NA 50% Human Human -DTXSID8046824 Css NA 3.737 mg/L PBTK NA 95% Human Human +DTXSID8046824 TK.Half.Life NA 11.32 hours 1compartment NA NA Human Human +DTXSID8046824 Css NA 0.722 mg/L 3compartmentss NA 50% Human Human +DTXSID8046824 Css NA 5.541 mg/L 3compartmentss NA 95% Human Human +DTXSID8046824 Css NA 0.6976 mg/L PBTK NA 50% Human Human +DTXSID8046824 Css NA 3.752 mg/L PBTK NA 95% Human Human DTXSID8046824 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8046824 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046824 Vd NA 1.353 L/kg 1compartment NA NA Rat Human +DTXSID8046824 Vd NA 1.417 L/kg 1compartment NA NA Rat Human DTXSID8046824 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046824 TK.Half.Life NA 3.052 hours 1compartment NA NA Rat Human -DTXSID8046824 Css NA 0.1883 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046824 Css NA 1.291 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046824 Css NA 0.1783 mg/L PBTK NA 50% Rat Human -DTXSID8046824 Css NA 0.8126 mg/L PBTK NA 95% Rat Human -DTXSID8046826 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046826 Fup NA 0.3504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046826 Vd NA 0.3175 L/kg 1compartment NA NA Human Human -DTXSID8046826 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046826 TK.Half.Life NA 5.864 hours 1compartment NA NA Human Human -DTXSID8046826 Css NA 2.258 mg/L 3compartmentss NA 50% Human Human -DTXSID8046826 Css NA 8.948 mg/L 3compartmentss NA 95% Human Human -DTXSID8046826 Css NA 1.518 mg/L PBTK NA 50% Human Human -DTXSID8046826 Css NA 5.445 mg/L PBTK NA 95% Human Human -DTXSID8046826 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046826 Fup NA 0.3504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046826 Vd NA 0.3351 L/kg 1compartment NA NA Rat Human -DTXSID8046826 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046826 TK.Half.Life NA 2.107 hours 1compartment NA NA Rat Human -DTXSID8046826 Css NA 0.6272 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046826 Css NA 2.102 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046826 Css NA 0.3974 mg/L PBTK NA 50% Rat Human -DTXSID8046826 Css NA 1.201 mg/L PBTK NA 95% Rat Human +DTXSID8046824 TK.Half.Life NA 3.218 hours 1compartment NA NA Rat Human +DTXSID8046824 Css NA 0.04172 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046824 Css NA 0.2867 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046824 Css NA 0.0416 mg/L PBTK NA 50% Rat Human +DTXSID8046824 Css NA 0.1882 mg/L PBTK NA 95% Rat Human DTXSID8046828 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8046828 Fup NA 0.4511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046828 Vd NA 0.3234 L/kg 1compartment NA NA Human Human +DTXSID8046828 Vd NA 0.3298 L/kg 1compartment NA NA Human Human DTXSID8046828 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046828 TK.Half.Life NA 4.64 hours 1compartment NA NA Human Human -DTXSID8046828 Css NA 1.768 mg/L 3compartmentss NA 50% Human Human -DTXSID8046828 Css NA 7.718 mg/L 3compartmentss NA 95% Human Human -DTXSID8046828 Css NA 1.197 mg/L PBTK NA 50% Human Human -DTXSID8046828 Css NA 4.73 mg/L PBTK NA 95% Human Human +DTXSID8046828 TK.Half.Life NA 4.731 hours 1compartment NA NA Human Human +DTXSID8046828 Css NA 0.938 mg/L 3compartmentss NA 50% Human Human +DTXSID8046828 Css NA 4.674 mg/L 3compartmentss NA 95% Human Human +DTXSID8046828 Css NA 0.6388 mg/L PBTK NA 50% Human Human +DTXSID8046828 Css NA 2.851 mg/L PBTK NA 95% Human Human DTXSID8046828 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8046828 Fup NA 0.4511 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046828 Vd NA 0.3406 L/kg 1compartment NA NA Rat Human +DTXSID8046828 Vd NA 0.346 L/kg 1compartment NA NA Rat Human DTXSID8046828 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046828 TK.Half.Life NA 1.665 hours 1compartment NA NA Rat Human -DTXSID8046828 Css NA 0.4863 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046828 Css NA 1.843 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046828 Css NA 0.3109 mg/L PBTK NA 50% Rat Human -DTXSID8046828 Css NA 1.049 mg/L PBTK NA 95% Rat Human -DTXSID8046870 Clint NA 11.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046870 Fup NA 0.6384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046870 Vd NA 0.8429 L/kg 1compartment NA NA Human Human +DTXSID8046828 TK.Half.Life NA 1.691 hours 1compartment NA NA Rat Human +DTXSID8046828 Css NA 0.00518 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046828 Css NA 0.02436 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046828 Css NA 0.003348 mg/L PBTK NA 50% Rat Human +DTXSID8046828 Css NA 0.01416 mg/L PBTK NA 95% Rat Human +DTXSID8046870 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046870 Fup 0.505 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046870 Vd NA 0.7316 L/kg 1compartment NA NA Human Human DTXSID8046870 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046870 TK.Half.Life NA 0.9077 hours 1compartment NA NA Human Human -DTXSID8046870 Css NA 0.06325 mg/L 3compartmentss NA 50% Human Human -DTXSID8046870 Css NA 0.6366 mg/L 3compartmentss NA 95% Human Human -DTXSID8046870 Css NA 0.05141 mg/L PBTK NA 50% Human Human -DTXSID8046870 Css NA 0.4315 mg/L PBTK NA 95% Human Human -DTXSID8046870 Clint NA 11.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046870 Fup NA 0.6384 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046870 Vd NA 0.8542 L/kg 1compartment NA NA Rat Human +DTXSID8046870 TK.Half.Life NA 9.395 hours 1compartment NA NA Human Human +DTXSID8046870 Css NA 1.196 mg/L 3compartmentss NA 50% Human Human +DTXSID8046870 Css NA 6.675 mg/L 3compartmentss NA 95% Human Human +DTXSID8046870 Css NA 0.9404 mg/L PBTK NA 50% Human Human +DTXSID8046870 Css NA 4.274 mg/L PBTK NA 95% Human Human +DTXSID8046870 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046870 Fup 0.505 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046870 Vd NA 0.7397 L/kg 1compartment NA NA Rat Human DTXSID8046870 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046870 TK.Half.Life NA 0.4784 hours 1compartment NA NA Rat Human -DTXSID8046870 Css NA 0.0314 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046870 Css NA 0.2576 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046870 Css NA 0.0247 mg/L PBTK NA 50% Rat Human -DTXSID8046870 Css NA 0.1635 mg/L PBTK NA 95% Rat Human -DTXSID8046872 Clint NA 11.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046872 Fup NA 0.0461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046872 Vd NA 2.689 L/kg 1compartment NA NA Human Human -DTXSID8046872 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID8046872 TK.Half.Life NA 42.55 hours 1compartment NA NA Human Human -DTXSID8046872 Css NA 2.093 mg/L 3compartmentss NA 50% Human Human -DTXSID8046872 Css NA 13.46 mg/L 3compartmentss NA 95% Human Human -DTXSID8046872 Css NA 1.418 mg/L PBTK NA 50% Human Human -DTXSID8046872 Css NA 8.845 mg/L PBTK NA 95% Human Human -DTXSID8046872 Clint NA 11.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046872 Fup NA 0.0461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046872 Vd NA 2.014 L/kg 1compartment NA NA Rat Human -DTXSID8046872 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID8046872 TK.Half.Life NA 9.088 hours 1compartment NA NA Rat Human -DTXSID8046872 Css NA 1.16 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046872 Css NA 5.568 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046872 Css NA 0.7502 mg/L PBTK NA 50% Rat Human -DTXSID8046872 Css NA 3.461 mg/L PBTK NA 95% Rat Human -DTXSID8046876 Clint NA 2712 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046876 Fup NA 0.1098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046876 Vd NA 1.929 L/kg 1compartment NA NA Human Human -DTXSID8046876 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046876 TK.Half.Life NA 1.569 hours 1compartment NA NA Human Human -DTXSID8046876 Css NA 0.002468 mg/L 3compartmentss NA 50% Human Human -DTXSID8046876 Css NA 0.02038 mg/L 3compartmentss NA 95% Human Human -DTXSID8046876 Css NA 0.001712 mg/L PBTK NA 50% Human Human -DTXSID8046876 Css NA 0.01337 mg/L PBTK NA 95% Human Human -DTXSID8046876 Clint NA 2712 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046876 Fup NA 0.1098 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046876 Vd NA 1.524 L/kg 1compartment NA NA Rat Human +DTXSID8046870 TK.Half.Life NA 3.231 hours 1compartment NA NA Rat Human +DTXSID8046870 Css NA 0.03021 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046870 Css NA 0.2122 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046870 Css NA 0.02328 mg/L PBTK NA 50% Rat Human +DTXSID8046870 Css NA 0.1352 mg/L PBTK NA 95% Rat Human +DTXSID8046876 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046876 Fup 0.076 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046876 Vd NA 1.503 L/kg 1compartment NA NA Human Human +DTXSID8046876 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8046876 TK.Half.Life NA 13.63 hours 1compartment NA NA Human Human +DTXSID8046876 Css NA 1.127 mg/L 3compartmentss NA 50% Human Human +DTXSID8046876 Css NA 7.25 mg/L 3compartmentss NA 95% Human Human +DTXSID8046876 Css NA 0.7501 mg/L PBTK NA 50% Human Human +DTXSID8046876 Css NA 4.547 mg/L PBTK NA 95% Human Human +DTXSID8046876 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046876 Fup 0.076 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046876 Vd NA 1.19 L/kg 1compartment NA NA Rat Human DTXSID8046876 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046876 TK.Half.Life NA 0.5419 hours 1compartment NA NA Rat Human -DTXSID8046876 Css NA 0.001407 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046876 Css NA 0.008957 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046876 Css NA 0.0009321 mg/L PBTK NA 50% Rat Human -DTXSID8046876 Css NA 0.005594 mg/L PBTK NA 95% Rat Human +DTXSID8046876 TK.Half.Life NA 5.617 hours 1compartment NA NA Rat Human +DTXSID8046876 Css NA 0.0525 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046876 Css NA 0.3784 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046876 Css NA 0.03375 mg/L PBTK NA 50% Rat Human +DTXSID8046876 Css NA 0.2262 mg/L PBTK NA 95% Rat Human DTXSID8046878 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8046878 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8046878 Vd NA 0.714 L/kg 1compartment NA NA Human Human +DTXSID8046878 Vd NA 0.5377 L/kg 1compartment NA NA Human Human DTXSID8046878 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046878 TK.Half.Life NA 5.501 hours 1compartment NA NA Human Human -DTXSID8046878 Css NA 0.968 mg/L 3compartmentss NA 50% Human Human -DTXSID8046878 Css NA 5.637 mg/L 3compartmentss NA 95% Human Human -DTXSID8046878 Css NA 0.7944 mg/L PBTK NA 50% Human Human -DTXSID8046878 Css NA 3.656 mg/L PBTK NA 95% Human Human +DTXSID8046878 TK.Half.Life NA 4.141 hours 1compartment NA NA Human Human +DTXSID8046878 Css NA 0.8678 mg/L 3compartmentss NA 50% Human Human +DTXSID8046878 Css NA 4.964 mg/L 3compartmentss NA 95% Human Human +DTXSID8046878 Css NA 0.673 mg/L PBTK NA 50% Human Human +DTXSID8046878 Css NA 3.151 mg/L PBTK NA 95% Human Human DTXSID8046878 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8046878 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8046878 Vd NA 0.7459 L/kg 1compartment NA NA Rat Human +DTXSID8046878 Vd NA 0.5667 L/kg 1compartment NA NA Rat Human DTXSID8046878 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046878 TK.Half.Life NA 1.959 hours 1compartment NA NA Rat Human -DTXSID8046878 Css NA 0.249 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046878 Css NA 1.445 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046878 Css NA 0.1976 mg/L PBTK NA 50% Rat Human -DTXSID8046878 Css NA 0.864 mg/L PBTK NA 95% Rat Human -DTXSID8046901 Clint NA 4202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046901 Fup NA 0.0815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046901 Vd NA 1.734 L/kg 1compartment NA NA Human Human -DTXSID8046901 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046901 TK.Half.Life NA 1.447 hours 1compartment NA NA Human Human -DTXSID8046901 Css NA 0.002074 mg/L 3compartmentss NA 50% Human Human -DTXSID8046901 Css NA 0.01697 mg/L 3compartmentss NA 95% Human Human -DTXSID8046901 Css NA 0.001402 mg/L PBTK NA 50% Human Human -DTXSID8046901 Css NA 0.01091 mg/L PBTK NA 95% Human Human -DTXSID8046901 Clint NA 4202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046901 Fup NA 0.0815 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046901 Vd NA 1.375 L/kg 1compartment NA NA Rat Human -DTXSID8046901 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046901 TK.Half.Life NA 0.503 hours 1compartment NA NA Rat Human -DTXSID8046901 Css NA 0.001178 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046901 Css NA 0.007902 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046901 Css NA 0.0007526 mg/L PBTK NA 50% Rat Human -DTXSID8046901 Css NA 0.004802 mg/L PBTK NA 95% Rat Human -DTXSID8046903 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046903 Fup NA 0.3598 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046903 Vd NA 2.649 L/kg 1compartment NA NA Human Human -DTXSID8046903 Days.Css NA 31 Days PBTK NA NA Human Human -DTXSID8046903 TK.Half.Life NA 159.1 hours 1compartment NA NA Human Human -DTXSID8046903 Css NA 6.434 mg/L 3compartmentss NA 50% Human Human -DTXSID8046903 Css NA 20.29 mg/L 3compartmentss NA 95% Human Human -DTXSID8046903 Css NA 4.906 mg/L PBTK NA 50% Human Human -DTXSID8046903 Css NA 13.8 mg/L PBTK NA 95% Human Human -DTXSID8046903 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046903 Fup NA 0.3598 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046903 Vd NA 2.036 L/kg 1compartment NA NA Rat Human -DTXSID8046903 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID8046903 TK.Half.Life NA 19.43 hours 1compartment NA NA Rat Human -DTXSID8046903 Css NA 1.738 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046903 Css NA 4.366 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046903 Css NA 1.278 mg/L PBTK NA 50% Rat Human -DTXSID8046903 Css NA 2.754 mg/L PBTK NA 95% Rat Human -DTXSID8046905 Clint NA 1.086 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046905 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046905 Vd NA 0.2659 L/kg 1compartment NA NA Human Human -DTXSID8046905 Days.Css NA 27 Days PBTK NA NA Human Human -DTXSID8046905 TK.Half.Life NA 123 hours 1compartment NA NA Human Human -DTXSID8046905 Css NA 80.96 mg/L 3compartmentss NA 50% Human Human -DTXSID8046905 Css NA 570.4 mg/L 3compartmentss NA 95% Human Human -DTXSID8046905 Css NA 48.16 mg/L PBTK NA 50% Human Human -DTXSID8046905 Css NA 324.1 mg/L PBTK NA 95% Human Human -DTXSID8046905 Clint NA 1.086 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046905 Fup NA 0.0048 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046905 Vd NA 0.2431 L/kg 1compartment NA NA Rat Human -DTXSID8046905 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID8046905 TK.Half.Life NA 57.81 hours 1compartment NA NA Rat Human -DTXSID8046905 Css NA 35.25 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046905 Css NA 201.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046905 Css NA 19.45 mg/L PBTK NA 50% Rat Human -DTXSID8046905 Css NA 109.4 mg/L PBTK NA 95% Rat Human -DTXSID8046909 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046909 Fup NA 0.7042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046909 Vd NA 0.6937 L/kg 1compartment NA NA Human Human +DTXSID8046878 TK.Half.Life NA 1.487 hours 1compartment NA NA Rat Human +DTXSID8046878 Css NA 0.01644 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046878 Css NA 0.1195 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046878 Css NA 0.01214 mg/L PBTK NA 50% Rat Human +DTXSID8046878 Css NA 0.07658 mg/L PBTK NA 95% Rat Human +DTXSID8046903 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046903 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046903 Vd NA 0.5294 L/kg 1compartment NA NA Human Human +DTXSID8046903 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8046903 TK.Half.Life NA 0.8924 hours 1compartment NA NA Human Human +DTXSID8046903 Css NA 0.1136 mg/L 3compartmentss NA 50% Human Human +DTXSID8046903 Css NA 0.8313 mg/L 3compartmentss NA 95% Human Human +DTXSID8046903 Css NA 0.08061 mg/L PBTK NA 50% Human Human +DTXSID8046903 Css NA 0.5555 mg/L PBTK NA 95% Human Human +DTXSID8046903 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046903 Fup 0.185 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046903 Vd NA 0.5232 L/kg 1compartment NA NA Rat Human +DTXSID8046903 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8046903 TK.Half.Life NA 0.4976 hours 1compartment NA NA Rat Human +DTXSID8046903 Css NA 0.01448 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046903 Css NA 0.0776 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046903 Css NA 0.01014 mg/L PBTK NA 50% Rat Human +DTXSID8046903 Css NA 0.05079 mg/L PBTK NA 95% Rat Human +DTXSID8046905 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046905 Fup 0.0898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046905 Vd NA 0.4509 L/kg 1compartment NA NA Human Human +DTXSID8046905 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8046905 TK.Half.Life NA 1.241 hours 1compartment NA NA Human Human +DTXSID8046905 Css NA 0.3049 mg/L 3compartmentss NA 50% Human Human +DTXSID8046905 Css NA 2.536 mg/L 3compartmentss NA 95% Human Human +DTXSID8046905 Css NA 0.2009 mg/L PBTK NA 50% Human Human +DTXSID8046905 Css NA 1.553 mg/L PBTK NA 95% Human Human +DTXSID8046905 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046905 Fup 0.0898 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046905 Vd NA 0.4419 L/kg 1compartment NA NA Rat Human +DTXSID8046905 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8046905 TK.Half.Life NA 0.7345 hours 1compartment NA NA Rat Human +DTXSID8046905 Css NA 0.04018 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046905 Css NA 0.257 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046905 Css NA 0.02555 mg/L PBTK NA 50% Rat Human +DTXSID8046905 Css NA 0.1521 mg/L PBTK NA 95% Rat Human +DTXSID8046909 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046909 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046909 Vd NA 0.4414 L/kg 1compartment NA NA Human Human DTXSID8046909 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046909 TK.Half.Life NA 6.454 hours 1compartment NA NA Human Human -DTXSID8046909 Css NA 1.115 mg/L 3compartmentss NA 50% Human Human -DTXSID8046909 Css NA 7.234 mg/L 3compartmentss NA 95% Human Human -DTXSID8046909 Css NA 0.8836 mg/L PBTK NA 50% Human Human -DTXSID8046909 Css NA 4.555 mg/L PBTK NA 95% Human Human -DTXSID8046909 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046909 Fup NA 0.7042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046909 Vd NA 0.6743 L/kg 1compartment NA NA Rat Human +DTXSID8046909 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human +DTXSID8046909 Css NA 0.8838 mg/L 3compartmentss NA 50% Human Human +DTXSID8046909 Css NA 4.434 mg/L 3compartmentss NA 95% Human Human +DTXSID8046909 Css NA 0.6324 mg/L PBTK NA 50% Human Human +DTXSID8046909 Css NA 2.752 mg/L PBTK NA 95% Human Human +DTXSID8046909 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046909 Fup 0.46 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046909 Vd NA 0.464 L/kg 1compartment NA NA Rat Human DTXSID8046909 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046909 TK.Half.Life NA 2.118 hours 1compartment NA NA Rat Human -DTXSID8046909 Css NA 0.2922 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046909 Css NA 1.797 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046909 Css NA 0.2225 mg/L PBTK NA 50% Rat Human -DTXSID8046909 Css NA 1.054 mg/L PBTK NA 95% Rat Human -DTXSID8046951 Clint NA 15.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046951 Fup NA 0.0709 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8046951 Vd NA 2.887 L/kg 1compartment NA NA Human Human +DTXSID8046909 TK.Half.Life NA 2.224 hours 1compartment NA NA Rat Human +DTXSID8046909 Css NA 0.00477 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046909 Css NA 0.02448 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046909 Css NA 0.003278 mg/L PBTK NA 50% Rat Human +DTXSID8046909 Css NA 0.01478 mg/L PBTK NA 95% Rat Human +DTXSID8046951 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046951 Fup 0.0702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8046951 Vd NA 3.04 L/kg 1compartment NA NA Human Human DTXSID8046951 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8046951 TK.Half.Life NA 9.732 hours 1compartment NA NA Human Human -DTXSID8046951 Css NA 0.3389 mg/L 3compartmentss NA 50% Human Human -DTXSID8046951 Css NA 2.357 mg/L 3compartmentss NA 95% Human Human -DTXSID8046951 Css NA 0.2682 mg/L PBTK NA 50% Human Human -DTXSID8046951 Css NA 1.684 mg/L PBTK NA 95% Human Human -DTXSID8046951 Clint NA 15.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046951 Fup NA 0.0709 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8046951 Vd NA 2.5 L/kg 1compartment NA NA Rat Human +DTXSID8046951 TK.Half.Life NA 8.092 hours 1compartment NA NA Human Human +DTXSID8046951 Css NA 0.2432 mg/L 3compartmentss NA 50% Human Human +DTXSID8046951 Css NA 1.738 mg/L 3compartmentss NA 95% Human Human +DTXSID8046951 Css NA 0.1903 mg/L PBTK NA 50% Human Human +DTXSID8046951 Css NA 1.26 mg/L PBTK NA 95% Human Human +DTXSID8046951 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046951 Fup 0.0702 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8046951 Vd NA 2.583 L/kg 1compartment NA NA Rat Human DTXSID8046951 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8046951 TK.Half.Life NA 3.79 hours 1compartment NA NA Rat Human -DTXSID8046951 Css NA 0.1853 mg/L 3compartmentss NA 50% Rat Human -DTXSID8046951 Css NA 1.004 mg/L 3compartmentss NA 95% Rat Human -DTXSID8046951 Css NA 0.1418 mg/L PBTK NA 50% Rat Human -DTXSID8046951 Css NA 0.6948 mg/L PBTK NA 95% Rat Human -DTXSID8047006 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047006 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047006 Vd NA 0.403 L/kg 1compartment NA NA Human Human -DTXSID8047006 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID8047006 TK.Half.Life NA 52.12 hours 1compartment NA NA Human Human -DTXSID8047006 Css NA 21.75 mg/L 3compartmentss NA 50% Human Human -DTXSID8047006 Css NA 103.3 mg/L 3compartmentss NA 95% Human Human -DTXSID8047006 Css NA 12.84 mg/L PBTK NA 50% Human Human -DTXSID8047006 Css NA 60.24 mg/L PBTK NA 95% Human Human -DTXSID8047006 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047006 Fup NA 0.0513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8046951 TK.Half.Life NA 2.831 hours 1compartment NA NA Rat Human +DTXSID8046951 Css NA 0.03093 mg/L 3compartmentss NA 50% Rat Human +DTXSID8046951 Css NA 0.1845 mg/L 3compartmentss NA 95% Rat Human +DTXSID8046951 Css NA 0.02427 mg/L PBTK NA 50% Rat Human +DTXSID8046951 Css NA 0.1339 mg/L PBTK NA 95% Rat Human +DTXSID8047000 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047000 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047000 Vd NA 0.9693 L/kg 1compartment NA NA Human Human +DTXSID8047000 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047000 TK.Half.Life NA 0.9274 hours 1compartment NA NA Human Human +DTXSID8047000 Css NA 0.0361 mg/L 3compartmentss NA 50% Human Human +DTXSID8047000 Css NA 0.35 mg/L 3compartmentss NA 95% Human Human +DTXSID8047000 Css NA 0.02941 mg/L PBTK NA 50% Human Human +DTXSID8047000 Css NA 0.2403 mg/L PBTK NA 95% Human Human +DTXSID8047000 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047000 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047000 Vd NA 0.8964 L/kg 1compartment NA NA Rat Human +DTXSID8047000 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047000 TK.Half.Life NA 0.4281 hours 1compartment NA NA Rat Human +DTXSID8047000 Css NA 0.004469 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047000 Css NA 0.03593 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047000 Css NA 0.00363 mg/L PBTK NA 50% Rat Human +DTXSID8047000 Css NA 0.02391 mg/L PBTK NA 95% Rat Human +DTXSID8047006 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047006 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047006 Vd NA 0.7602 L/kg 1compartment NA NA Human Human +DTXSID8047006 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8047006 TK.Half.Life NA 27.67 hours 1compartment NA NA Human Human +DTXSID8047006 Css NA 3.982 mg/L 3compartmentss NA 50% Human Human +DTXSID8047006 Css NA 13.95 mg/L 3compartmentss NA 95% Human Human +DTXSID8047006 Css NA 2.498 mg/L PBTK NA 50% Human Human +DTXSID8047006 Css NA 8.353 mg/L PBTK NA 95% Human Human +DTXSID8047006 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047006 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8047006 Vd NA 0.311 L/kg 1compartment NA NA Rat Human DTXSID8047006 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID8047006 TK.Half.Life NA 13.8 hours 1compartment NA NA Rat Human -DTXSID8047006 Css NA 6.4 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047006 Css NA 25.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047006 Css NA 3.528 mg/L PBTK NA 50% Rat Human -DTXSID8047006 Css NA 14.08 mg/L PBTK NA 95% Rat Human +DTXSID8047006 Css NA 0.3552 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047006 Css NA 2.402 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047006 Css NA 0.1987 mg/L PBTK NA 50% Rat Human +DTXSID8047006 Css NA 1.348 mg/L PBTK NA 95% Rat Human +DTXSID8047050 Clint 172 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID8047050 Fup 8.72e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human +DTXSID8047050 Vd NA 0.2316 L/kg 1compartment NA NA Human Human +DTXSID8047050 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8047050 TK.Half.Life NA 27.85 hours 1compartment NA NA Human Human +DTXSID8047050 Css NA 0.2948 mg/L 3compartmentss NA 50% Human Human +DTXSID8047050 Css NA 3.411 mg/L 3compartmentss NA 95% Human Human +DTXSID8047050 Css NA 0.1838 mg/L PBTK NA 50% Human Human +DTXSID8047050 Css NA 2.069 mg/L PBTK NA 95% Human Human +DTXSID8047050 Clint 172 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID8047050 Fup 8.72e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human +DTXSID8047050 Vd NA 0.1964 L/kg 1compartment NA NA Rat Human +DTXSID8047050 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8047050 TK.Half.Life NA 16.5 hours 1compartment NA NA Rat Human +DTXSID8047050 Css NA 0.03692 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047050 Css NA 0.3915 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047050 Css NA 0.0225 mg/L PBTK NA 50% Rat Human +DTXSID8047050 Css NA 0.2302 mg/L PBTK NA 95% Rat Human DTXSID8047056 Clint NA 1128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8047056 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047056 Vd NA 8.785 L/kg 1compartment NA NA Human Human +DTXSID8047056 Vd NA 0.5891 L/kg 1compartment NA NA Human Human DTXSID8047056 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047056 TK.Half.Life NA 4.151 hours 1compartment NA NA Human Human -DTXSID8047056 Css NA 0.001897 mg/L 3compartmentss NA 50% Human Human -DTXSID8047056 Css NA 0.02624 mg/L 3compartmentss NA 95% Human Human -DTXSID8047056 Css NA 0.002088 mg/L PBTK NA 50% Human Human -DTXSID8047056 Css NA 0.02085 mg/L PBTK NA 95% Human Human +DTXSID8047056 TK.Half.Life NA 0.6273 hours 1compartment NA NA Human Human +DTXSID8047056 Css NA 0.0154 mg/L 3compartmentss NA 50% Human Human +DTXSID8047056 Css NA 0.2136 mg/L 3compartmentss NA 95% Human Human +DTXSID8047056 Css NA 0.009389 mg/L PBTK NA 50% Human Human +DTXSID8047056 Css NA 0.1265 mg/L PBTK NA 95% Human Human DTXSID8047056 Clint NA 1128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8047056 Fup NA 0.0047 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047056 Vd NA 7.082 L/kg 1compartment NA NA Rat Human +DTXSID8047056 Vd NA 0.543 L/kg 1compartment NA NA Rat Human DTXSID8047056 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047056 TK.Half.Life NA 1.494 hours 1compartment NA NA Rat Human -DTXSID8047056 Css NA 0.001044 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047056 Css NA 0.01308 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047056 Css NA 0.00113 mg/L PBTK NA 50% Rat Human -DTXSID8047056 Css NA 0.009535 mg/L PBTK NA 95% Rat Human -DTXSID8047058 Clint NA 10.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047058 Fup NA 0.8964 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047058 Vd NA 1.035 L/kg 1compartment NA NA Human Human +DTXSID8047056 TK.Half.Life NA 0.2719 hours 1compartment NA NA Rat Human +DTXSID8047056 Css NA 0.0005856 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047056 Css NA 0.009412 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047056 Css NA 0.000341 mg/L PBTK NA 50% Rat Human +DTXSID8047056 Css NA 0.005303 mg/L PBTK NA 95% Rat Human +DTXSID8047058 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047058 Fup 0.764 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047058 Vd NA 0.8819 L/kg 1compartment NA NA Human Human DTXSID8047058 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047058 TK.Half.Life NA 0.9252 hours 1compartment NA NA Human Human -DTXSID8047058 Css NA 0.05178 mg/L 3compartmentss NA 50% Human Human -DTXSID8047058 Css NA 0.4723 mg/L 3compartmentss NA 95% Human Human -DTXSID8047058 Css NA 0.0448 mg/L PBTK NA 50% Human Human -DTXSID8047058 Css NA 0.3325 mg/L PBTK NA 95% Human Human -DTXSID8047058 Clint NA 10.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047058 Fup NA 0.8964 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047058 Vd NA 1.016 L/kg 1compartment NA NA Rat Human +DTXSID8047058 TK.Half.Life NA 0.6948 hours 1compartment NA NA Human Human +DTXSID8047058 Css NA 0.02699 mg/L 3compartmentss NA 50% Human Human +DTXSID8047058 Css NA 0.2677 mg/L 3compartmentss NA 95% Human Human +DTXSID8047058 Css NA 0.0225 mg/L PBTK NA 50% Human Human +DTXSID8047058 Css NA 0.1917 mg/L PBTK NA 95% Human Human +DTXSID8047058 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047058 Fup 0.764 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047058 Vd NA 0.8759 L/kg 1compartment NA NA Rat Human DTXSID8047058 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047058 TK.Half.Life NA 0.4606 hours 1compartment NA NA Rat Human -DTXSID8047058 Css NA 0.02541 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047058 Css NA 0.1878 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047058 Css NA 0.02186 mg/L PBTK NA 50% Rat Human -DTXSID8047058 Css NA 0.1279 mg/L PBTK NA 95% Rat Human -DTXSID8047137 Clint NA 1.115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047137 Fup NA 0.1605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047137 Vd NA 0.3556 L/kg 1compartment NA NA Human Human +DTXSID8047058 TK.Half.Life NA 0.3357 hours 1compartment NA NA Rat Human +DTXSID8047058 Css NA 0.003147 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047058 Css NA 0.02995 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047058 Css NA 0.002684 mg/L PBTK NA 50% Rat Human +DTXSID8047058 Css NA 0.02022 mg/L PBTK NA 95% Rat Human +DTXSID8047131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047131 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047131 Vd NA 2.032 L/kg 1compartment NA NA Human Human +DTXSID8047131 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047131 TK.Half.Life NA 6.769 hours 1compartment NA NA Human Human +DTXSID8047131 Css NA 0.3673 mg/L 3compartmentss NA 50% Human Human +DTXSID8047131 Css NA 2.553 mg/L 3compartmentss NA 95% Human Human +DTXSID8047131 Css NA 0.2484 mg/L PBTK NA 50% Human Human +DTXSID8047131 Css NA 1.644 mg/L PBTK NA 95% Human Human +DTXSID8047131 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047131 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047131 Vd NA 1.539 L/kg 1compartment NA NA Rat Human +DTXSID8047131 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047131 TK.Half.Life NA 2.222 hours 1compartment NA NA Rat Human +DTXSID8047131 Css NA 0.04678 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047131 Css NA 0.2627 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047131 Css NA 0.03124 mg/L PBTK NA 50% Rat Human +DTXSID8047131 Css NA 0.1656 mg/L PBTK NA 95% Rat Human +DTXSID8047137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047137 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047137 Vd NA 0.4539 L/kg 1compartment NA NA Human Human DTXSID8047137 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047137 TK.Half.Life NA 5.165 hours 1compartment NA NA Human Human -DTXSID8047137 Css NA 1.976 mg/L 3compartmentss NA 50% Human Human -DTXSID8047137 Css NA 9.78 mg/L 3compartmentss NA 95% Human Human -DTXSID8047137 Css NA 1.261 mg/L PBTK NA 50% Human Human -DTXSID8047137 Css NA 5.823 mg/L PBTK NA 95% Human Human -DTXSID8047137 Clint NA 1.115 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047137 Fup NA 0.1605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047137 Vd NA 0.3382 L/kg 1compartment NA NA Rat Human +DTXSID8047137 TK.Half.Life NA 0.6319 hours 1compartment NA NA Human Human +DTXSID8047137 Css NA 0.03471 mg/L 3compartmentss NA 50% Human Human +DTXSID8047137 Css NA 0.3167 mg/L 3compartmentss NA 95% Human Human +DTXSID8047137 Css NA 0.02342 mg/L PBTK NA 50% Human Human +DTXSID8047137 Css NA 0.2005 mg/L PBTK NA 95% Human Human +DTXSID8047137 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047137 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047137 Vd NA 0.4342 L/kg 1compartment NA NA Rat Human DTXSID8047137 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047137 TK.Half.Life NA 2.474 hours 1compartment NA NA Rat Human -DTXSID8047137 Css NA 0.8398 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047137 Css NA 3.19 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047137 Css NA 0.501 mg/L PBTK NA 50% Rat Human -DTXSID8047137 Css NA 1.779 mg/L PBTK NA 95% Rat Human -DTXSID8047183 Clint NA 2.431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047183 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047183 Vd NA 0.6997 L/kg 1compartment NA NA Human Human -DTXSID8047183 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8047183 TK.Half.Life NA 25.98 hours 1compartment NA NA Human Human -DTXSID8047183 Css NA 6.368 mg/L 3compartmentss NA 50% Human Human -DTXSID8047183 Css NA 37.9 mg/L 3compartmentss NA 95% Human Human -DTXSID8047183 Css NA 4.01 mg/L PBTK NA 50% Human Human -DTXSID8047183 Css NA 22.46 mg/L PBTK NA 95% Human Human -DTXSID8047183 Clint NA 2.431 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047183 Fup NA 0.0341 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047183 Vd NA 0.557 L/kg 1compartment NA NA Rat Human -DTXSID8047183 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8047183 TK.Half.Life NA 11.5 hours 1compartment NA NA Rat Human -DTXSID8047183 Css NA 3.158 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047183 Css NA 14.33 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047183 Css NA 1.854 mg/L PBTK NA 50% Rat Human -DTXSID8047183 Css NA 7.936 mg/L PBTK NA 95% Rat Human -DTXSID8047218 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047218 Fup NA 0.4955 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047218 Vd NA 0.4801 L/kg 1compartment NA NA Human Human -DTXSID8047218 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047218 TK.Half.Life NA 6.267 hours 1compartment NA NA Human Human -DTXSID8047218 Css NA 1.5 mg/L 3compartmentss NA 50% Human Human -DTXSID8047218 Css NA 7.704 mg/L 3compartmentss NA 95% Human Human -DTXSID8047218 Css NA 1.104 mg/L PBTK NA 50% Human Human -DTXSID8047218 Css NA 4.815 mg/L PBTK NA 95% Human Human -DTXSID8047218 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047218 Fup NA 0.4955 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047218 Vd NA 0.5098 L/kg 1compartment NA NA Rat Human -DTXSID8047218 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047218 TK.Half.Life NA 2.268 hours 1compartment NA NA Rat Human -DTXSID8047218 Css NA 0.4114 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047218 Css NA 1.824 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047218 Css NA 0.2892 mg/L PBTK NA 50% Rat Human -DTXSID8047218 Css NA 1.065 mg/L PBTK NA 95% Rat Human -DTXSID8047262 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047262 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047262 Vd NA 0.5047 L/kg 1compartment NA NA Human Human -DTXSID8047262 Days.Css NA 75 Days PBTK NA NA Human Human -DTXSID8047262 TK.Half.Life NA 303.9 hours 1compartment NA NA Human Human -DTXSID8047262 Css NA 103.3 mg/L 3compartmentss NA 50% Human Human -DTXSID8047262 Css NA 620 mg/L 3compartmentss NA 95% Human Human -DTXSID8047262 Css NA 61.26 mg/L PBTK NA 50% Human Human -DTXSID8047262 Css NA 359.3 mg/L PBTK NA 95% Human Human -DTXSID8047262 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047262 Fup NA 0.0112 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047262 Vd NA 0.3859 L/kg 1compartment NA NA Rat Human -DTXSID8047262 Days.Css NA 16 Days PBTK NA NA Rat Human -DTXSID8047262 TK.Half.Life NA 76.73 hours 1compartment NA NA Rat Human -DTXSID8047262 Css NA 28.98 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047262 Css NA 149.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047262 Css NA 16.01 mg/L PBTK NA 50% Rat Human -DTXSID8047262 Css NA 81.11 mg/L PBTK NA 95% Rat Human -DTXSID8047264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047264 Fup NA 0.082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047264 Vd NA 0.6493 L/kg 1compartment NA NA Human Human -DTXSID8047264 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID8047264 TK.Half.Life NA 51.23 hours 1compartment NA NA Human Human -DTXSID8047264 Css NA 11.86 mg/L 3compartmentss NA 50% Human Human -DTXSID8047264 Css NA 56.72 mg/L 3compartmentss NA 95% Human Human -DTXSID8047264 Css NA 7.738 mg/L PBTK NA 50% Human Human -DTXSID8047264 Css NA 33.8 mg/L PBTK NA 95% Human Human -DTXSID8047264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047264 Fup NA 0.082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047264 Vd NA 0.6256 L/kg 1compartment NA NA Rat Human -DTXSID8047264 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8047264 TK.Half.Life NA 16.82 hours 1compartment NA NA Rat Human -DTXSID8047264 Css NA 3.335 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047264 Css NA 13.28 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047264 Css NA 2.039 mg/L PBTK NA 50% Rat Human -DTXSID8047264 Css NA 7.433 mg/L PBTK NA 95% Rat Human +DTXSID8047137 TK.Half.Life NA 0.3211 hours 1compartment NA NA Rat Human +DTXSID8047137 Css NA 0.0003206 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047137 Css NA 0.002798 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047137 Css NA 0.0002073 mg/L PBTK NA 50% Rat Human +DTXSID8047137 Css NA 0.001696 mg/L PBTK NA 95% Rat Human +DTXSID8047183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047183 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047183 Vd NA 0.2528 L/kg 1compartment NA NA Human Human +DTXSID8047183 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047183 TK.Half.Life NA 0.4965 hours 1compartment NA NA Human Human +DTXSID8047183 Css NA 0.167 mg/L 3compartmentss NA 50% Human Human +DTXSID8047183 Css NA 1.305 mg/L 3compartmentss NA 95% Human Human +DTXSID8047183 Css NA 0.1031 mg/L PBTK NA 50% Human Human +DTXSID8047183 Css NA 0.7793 mg/L PBTK NA 95% Human Human +DTXSID8047183 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047183 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047183 Vd NA 0.2553 L/kg 1compartment NA NA Rat Human +DTXSID8047183 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047183 TK.Half.Life NA 0.2833 hours 1compartment NA NA Rat Human +DTXSID8047183 Css NA 0.0217 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047183 Css NA 0.1283 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047183 Css NA 0.01306 mg/L PBTK NA 50% Rat Human +DTXSID8047183 Css NA 0.0742 mg/L PBTK NA 95% Rat Human +DTXSID8047185 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047185 Fup 0.0495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047185 Vd NA 2.805 L/kg 1compartment NA NA Human Human +DTXSID8047185 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8047185 TK.Half.Life NA 27.34 hours 1compartment NA NA Human Human +DTXSID8047185 Css NA 1.186 mg/L 3compartmentss NA 50% Human Human +DTXSID8047185 Css NA 7.874 mg/L 3compartmentss NA 95% Human Human +DTXSID8047185 Css NA 0.8104 mg/L PBTK NA 50% Human Human +DTXSID8047185 Css NA 5.181 mg/L PBTK NA 95% Human Human +DTXSID8047185 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047185 Fup 0.0495 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047185 Vd NA 2.103 L/kg 1compartment NA NA Rat Human +DTXSID8047185 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8047185 TK.Half.Life NA 5.492 hours 1compartment NA NA Rat Human +DTXSID8047185 Css NA 0.154 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047185 Css NA 0.8356 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047185 Css NA 0.104 mg/L PBTK NA 50% Rat Human +DTXSID8047185 Css NA 0.5483 mg/L PBTK NA 95% Rat Human +DTXSID8047187 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047187 Fup 0.0331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047187 Vd NA 3.115 L/kg 1compartment NA NA Human Human +DTXSID8047187 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID8047187 TK.Half.Life NA 82.57 hours 1compartment NA NA Human Human +DTXSID8047187 Css NA 3.105 mg/L 3compartmentss NA 50% Human Human +DTXSID8047187 Css NA 19.66 mg/L 3compartmentss NA 95% Human Human +DTXSID8047187 Css NA 2.143 mg/L PBTK NA 50% Human Human +DTXSID8047187 Css NA 13.13 mg/L PBTK NA 95% Human Human +DTXSID8047187 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047187 Fup 0.0331 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047187 Vd NA 2.334 L/kg 1compartment NA NA Rat Human +DTXSID8047187 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID8047187 TK.Half.Life NA 11.22 hours 1compartment NA NA Rat Human +DTXSID8047187 Css NA 0.4072 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047187 Css NA 2.213 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047187 Css NA 0.28 mg/L PBTK NA 50% Rat Human +DTXSID8047187 Css NA 1.455 mg/L PBTK NA 95% Rat Human +DTXSID8047262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047262 Fup 0.0209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047262 Vd NA 0.5491 L/kg 1compartment NA NA Human Human +DTXSID8047262 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047262 TK.Half.Life NA 4.738 hours 1compartment NA NA Human Human +DTXSID8047262 Css NA 1.42 mg/L 3compartmentss NA 50% Human Human +DTXSID8047262 Css NA 14.09 mg/L 3compartmentss NA 95% Human Human +DTXSID8047262 Css NA 0.8472 mg/L PBTK NA 50% Human Human +DTXSID8047262 Css NA 8.228 mg/L PBTK NA 95% Human Human +DTXSID8047262 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047262 Fup 0.0209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047262 Vd NA 0.423 L/kg 1compartment NA NA Rat Human +DTXSID8047262 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047262 TK.Half.Life NA 2.316 hours 1compartment NA NA Rat Human +DTXSID8047262 Css NA 0.1865 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047262 Css NA 1.452 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047262 Css NA 0.1084 mg/L PBTK NA 50% Rat Human +DTXSID8047262 Css NA 0.8191 mg/L PBTK NA 95% Rat Human +DTXSID8047264 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047264 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047264 Vd NA 1.551 L/kg 1compartment NA NA Human Human +DTXSID8047264 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047264 TK.Half.Life NA 4.153 hours 1compartment NA NA Human Human +DTXSID8047264 Css NA 0.2046 mg/L 3compartmentss NA 50% Human Human +DTXSID8047264 Css NA 1.361 mg/L 3compartmentss NA 95% Human Human +DTXSID8047264 Css NA 0.1786 mg/L PBTK NA 50% Human Human +DTXSID8047264 Css NA 1.017 mg/L PBTK NA 95% Human Human +DTXSID8047264 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047264 Fup 0.239 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047264 Vd NA 1.518 L/kg 1compartment NA NA Rat Human +DTXSID8047264 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047264 TK.Half.Life NA 2.412 hours 1compartment NA NA Rat Human +DTXSID8047264 Css NA 0.02409 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047264 Css NA 0.1191 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047264 Css NA 0.02123 mg/L PBTK NA 50% Rat Human +DTXSID8047264 Css NA 0.08728 mg/L PBTK NA 95% Rat Human DTXSID8047266 Clint 2.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID8047266 Fup 0.145 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8047266 Vd NA 0.8148 L/kg 1compartment NA NA Human Human +DTXSID8047266 Vd NA 0.5379 L/kg 1compartment NA NA Human Human DTXSID8047266 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047266 TK.Half.Life NA 8.329 hours 1compartment NA NA Human Human -DTXSID8047266 Css NA 1.158 mg/L 3compartmentss NA 50% Human Human -DTXSID8047266 Css NA 5.036 mg/L 3compartmentss NA 95% Human Human -DTXSID8047266 Css NA 0.7713 mg/L PBTK NA 50% Human Human -DTXSID8047266 Css NA 3.158 mg/L PBTK NA 95% Human Human +DTXSID8047266 TK.Half.Life NA 5.344 hours 1compartment NA NA Human Human +DTXSID8047266 Css NA 0.9688 mg/L 3compartmentss NA 50% Human Human +DTXSID8047266 Css NA 4.4 mg/L 3compartmentss NA 95% Human Human +DTXSID8047266 Css NA 0.6337 mg/L PBTK NA 50% Human Human +DTXSID8047266 Css NA 2.707 mg/L PBTK NA 95% Human Human DTXSID8047266 Clint 2.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID8047266 Fup 0.145 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8047266 Vd NA 0.6588 L/kg 1compartment NA NA Rat Human +DTXSID8047266 Vd NA 0.4638 L/kg 1compartment NA NA Rat Human DTXSID8047266 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047266 TK.Half.Life NA 3.578 hours 1compartment NA NA Rat Human -DTXSID8047266 Css NA 0.5386 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047266 Css NA 1.687 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047266 Css NA 0.3425 mg/L PBTK NA 50% Rat Human -DTXSID8047266 Css NA 0.9952 mg/L PBTK NA 95% Rat Human -DTXSID8047268 Clint NA 1.129 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047268 Fup NA 0.0373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047268 Vd NA 0.3668 L/kg 1compartment NA NA Human Human -DTXSID8047268 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8047268 TK.Half.Life NA 21.92 hours 1compartment NA NA Human Human -DTXSID8047268 Css NA 10.58 mg/L 3compartmentss NA 50% Human Human -DTXSID8047268 Css NA 66.01 mg/L 3compartmentss NA 95% Human Human -DTXSID8047268 Css NA 6.354 mg/L PBTK NA 50% Human Human -DTXSID8047268 Css NA 38.41 mg/L PBTK NA 95% Human Human -DTXSID8047268 Clint NA 1.129 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047268 Fup NA 0.0373 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047268 Vd NA 0.3118 L/kg 1compartment NA NA Rat Human -DTXSID8047268 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8047268 TK.Half.Life NA 9.5 hours 1compartment NA NA Rat Human -DTXSID8047268 Css NA 4.552 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047268 Css NA 22.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047268 Css NA 2.548 mg/L PBTK NA 50% Rat Human -DTXSID8047268 Css NA 12.38 mg/L PBTK NA 95% Rat Human -DTXSID8047341 Clint NA 24.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047341 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047341 Vd NA 3.106 L/kg 1compartment NA NA Human Human -DTXSID8047341 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID8047341 TK.Half.Life NA 79.83 hours 1compartment NA NA Human Human -DTXSID8047341 Css NA 3.1 mg/L 3compartmentss NA 50% Human Human -DTXSID8047341 Css NA 19.63 mg/L 3compartmentss NA 95% Human Human -DTXSID8047341 Css NA 2.152 mg/L PBTK NA 50% Human Human -DTXSID8047341 Css NA 13.23 mg/L PBTK NA 95% Human Human -DTXSID8047341 Clint NA 24.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047341 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047341 Vd NA 2.327 L/kg 1compartment NA NA Rat Human -DTXSID8047341 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID8047341 TK.Half.Life NA 11.01 hours 1compartment NA NA Rat Human -DTXSID8047341 Css NA 1.774 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047341 Css NA 7.861 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047341 Css NA 1.175 mg/L PBTK NA 50% Rat Human -DTXSID8047341 Css NA 5.118 mg/L PBTK NA 95% Rat Human -DTXSID8047347 Clint NA 14.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047347 Fup NA 0.0987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047347 Vd NA 1.528 L/kg 1compartment NA NA Human Human +DTXSID8047266 TK.Half.Life NA 2.535 hours 1compartment NA NA Rat Human +DTXSID8047266 Css NA 0.03944 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047266 Css NA 0.2168 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047266 Css NA 0.02494 mg/L PBTK NA 50% Rat Human +DTXSID8047266 Css NA 0.1302 mg/L PBTK NA 95% Rat Human +DTXSID8047268 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047268 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047268 Vd NA 0.633 L/kg 1compartment NA NA Human Human +DTXSID8047268 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047268 TK.Half.Life NA 3.731 hours 1compartment NA NA Human Human +DTXSID8047268 Css NA 0.8104 mg/L 3compartmentss NA 50% Human Human +DTXSID8047268 Css NA 5.514 mg/L 3compartmentss NA 95% Human Human +DTXSID8047268 Css NA 0.5152 mg/L PBTK NA 50% Human Human +DTXSID8047268 Css NA 3.339 mg/L PBTK NA 95% Human Human +DTXSID8047268 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047268 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047268 Vd NA 0.5288 L/kg 1compartment NA NA Rat Human +DTXSID8047268 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047268 TK.Half.Life NA 1.846 hours 1compartment NA NA Rat Human +DTXSID8047268 Css NA 0.0999 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047268 Css NA 0.5203 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047268 Css NA 0.06195 mg/L PBTK NA 50% Rat Human +DTXSID8047268 Css NA 0.3037 mg/L PBTK NA 95% Rat Human +DTXSID8047341 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047341 Fup 0.022 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047341 Vd NA 5.224 L/kg 1compartment NA NA Human Human +DTXSID8047341 Days.Css NA 27 Days PBTK NA NA Human Human +DTXSID8047341 TK.Half.Life NA 151.4 hours 1compartment NA NA Human Human +DTXSID8047341 Css NA 2.544 mg/L 3compartmentss NA 50% Human Human +DTXSID8047341 Css NA 15.95 mg/L 3compartmentss NA 95% Human Human +DTXSID8047341 Css NA 2.102 mg/L PBTK NA 50% Human Human +DTXSID8047341 Css NA 12.8 mg/L PBTK NA 95% Human Human +DTXSID8047341 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047341 Fup 0.022 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047341 Vd NA 3.996 L/kg 1compartment NA NA Rat Human +DTXSID8047341 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID8047341 TK.Half.Life NA 20.64 hours 1compartment NA NA Rat Human +DTXSID8047341 Css NA 0.127 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047341 Css NA 0.8319 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047341 Css NA 0.104 mg/L PBTK NA 50% Rat Human +DTXSID8047341 Css NA 0.6399 mg/L PBTK NA 95% Rat Human +DTXSID8047347 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047347 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047347 Vd NA 1.548 L/kg 1compartment NA NA Human Human DTXSID8047347 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047347 TK.Half.Life NA 3.206 hours 1compartment NA NA Human Human -DTXSID8047347 Css NA 0.1947 mg/L 3compartmentss NA 50% Human Human -DTXSID8047347 Css NA 1.754 mg/L 3compartmentss NA 95% Human Human -DTXSID8047347 Css NA 0.1562 mg/L PBTK NA 50% Human Human -DTXSID8047347 Css NA 1.2 mg/L PBTK NA 95% Human Human -DTXSID8047347 Clint NA 14.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047347 Fup NA 0.0987 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047347 Vd NA 1.488 L/kg 1compartment NA NA Rat Human +DTXSID8047347 TK.Half.Life NA 6.006 hours 1compartment NA NA Human Human +DTXSID8047347 Css NA 0.4152 mg/L 3compartmentss NA 50% Human Human +DTXSID8047347 Css NA 3.623 mg/L 3compartmentss NA 95% Human Human +DTXSID8047347 Css NA 0.3364 mg/L PBTK NA 50% Human Human +DTXSID8047347 Css NA 2.488 mg/L PBTK NA 95% Human Human +DTXSID8047347 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047347 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047347 Vd NA 1.509 L/kg 1compartment NA NA Rat Human DTXSID8047347 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047347 TK.Half.Life NA 1.886 hours 1compartment NA NA Rat Human -DTXSID8047347 Css NA 0.1083 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047347 Css NA 0.7529 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047347 Css NA 0.08396 mg/L PBTK NA 50% Rat Human -DTXSID8047347 Css NA 0.4853 mg/L PBTK NA 95% Rat Human -DTXSID8047349 Clint NA 9.864 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047349 Fup NA 0.0348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047349 Vd NA 0.3903 L/kg 1compartment NA NA Human Human +DTXSID8047347 TK.Half.Life NA 3.65 hours 1compartment NA NA Rat Human +DTXSID8047347 Css NA 0.05156 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047347 Css NA 0.3582 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047347 Css NA 0.04161 mg/L PBTK NA 50% Rat Human +DTXSID8047347 Css NA 0.2345 mg/L PBTK NA 95% Rat Human +DTXSID8047349 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047349 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047349 Vd NA 0.4856 L/kg 1compartment NA NA Human Human DTXSID8047349 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047349 TK.Half.Life NA 4.359 hours 1compartment NA NA Human Human -DTXSID8047349 Css NA 1.978 mg/L 3compartmentss NA 50% Human Human -DTXSID8047349 Css NA 13.58 mg/L 3compartmentss NA 95% Human Human -DTXSID8047349 Css NA 1.183 mg/L PBTK NA 50% Human Human -DTXSID8047349 Css NA 7.884 mg/L PBTK NA 95% Human Human -DTXSID8047349 Clint NA 9.864 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047349 Fup NA 0.0348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047349 Vd NA 0.3235 L/kg 1compartment NA NA Rat Human +DTXSID8047349 TK.Half.Life NA 0.893 hours 1compartment NA NA Human Human +DTXSID8047349 Css NA 0.1204 mg/L 3compartmentss NA 50% Human Human +DTXSID8047349 Css NA 0.9626 mg/L 3compartmentss NA 95% Human Human +DTXSID8047349 Css NA 0.08283 mg/L PBTK NA 50% Human Human +DTXSID8047349 Css NA 0.6187 mg/L PBTK NA 95% Human Human +DTXSID8047349 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047349 Fup 0.163 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047349 Vd NA 0.4808 L/kg 1compartment NA NA Rat Human DTXSID8047349 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047349 TK.Half.Life NA 2.294 hours 1compartment NA NA Rat Human -DTXSID8047349 Css NA 1.094 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047349 Css NA 5.885 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047349 Css NA 0.6096 mg/L PBTK NA 50% Rat Human -DTXSID8047349 Css NA 3.221 mg/L PBTK NA 95% Rat Human -DTXSID8047391 Clint NA 10.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047391 Fup NA 0.0429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047391 Vd NA 0.239 L/kg 1compartment NA NA Human Human +DTXSID8047349 TK.Half.Life NA 0.5045 hours 1compartment NA NA Rat Human +DTXSID8047349 Css NA 0.005702 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047349 Css NA 0.05041 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047349 Css NA 0.003851 mg/L PBTK NA 50% Rat Human +DTXSID8047349 Css NA 0.03117 mg/L PBTK NA 95% Rat Human +DTXSID8047391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047391 Fup 0.0447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047391 Vd NA 0.8953 L/kg 1compartment NA NA Human Human DTXSID8047391 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047391 TK.Half.Life NA 2.167 hours 1compartment NA NA Human Human -DTXSID8047391 Css NA 1.52 mg/L 3compartmentss NA 50% Human Human -DTXSID8047391 Css NA 12.32 mg/L 3compartmentss NA 95% Human Human -DTXSID8047391 Css NA 0.9035 mg/L PBTK NA 50% Human Human -DTXSID8047391 Css NA 7.201 mg/L PBTK NA 95% Human Human -DTXSID8047391 Clint NA 10.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047391 Fup NA 0.0429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047391 Vd NA 0.2252 L/kg 1compartment NA NA Rat Human +DTXSID8047391 TK.Half.Life NA 4.201 hours 1compartment NA NA Human Human +DTXSID8047391 Css NA 0.6584 mg/L 3compartmentss NA 50% Human Human +DTXSID8047391 Css NA 5.346 mg/L 3compartmentss NA 95% Human Human +DTXSID8047391 Css NA 0.4082 mg/L PBTK NA 50% Human Human +DTXSID8047391 Css NA 3.242 mg/L PBTK NA 95% Human Human +DTXSID8047391 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047391 Fup 0.0447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047391 Vd NA 0.6836 L/kg 1compartment NA NA Rat Human DTXSID8047391 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047391 TK.Half.Life NA 1.301 hours 1compartment NA NA Rat Human -DTXSID8047391 Css NA 0.8384 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047391 Css NA 5.257 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047391 Css NA 0.4662 mg/L PBTK NA 50% Rat Human -DTXSID8047391 Css NA 2.87 mg/L PBTK NA 95% Rat Human -DTXSID8047395 Clint NA 121.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047395 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047395 Vd NA 618.2 L/kg 1compartment NA NA Human Human -DTXSID8047395 Days.Css NA 861 Days PBTK NA NA Human Human -DTXSID8047395 TK.Half.Life NA 3291 hours 1compartment NA NA Human Human -DTXSID8047395 Css NA 0.004745 mg/L 3compartmentss NA 50% Human Human -DTXSID8047395 Css NA 0.02957 mg/L 3compartmentss NA 95% Human Human -DTXSID8047395 Css NA 0.4412 mg/L PBTK NA 50% Human Human -DTXSID8047395 Css NA 2.486 mg/L PBTK NA 95% Human Human -DTXSID8047395 Clint NA 121.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047395 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047395 Vd NA 561 L/kg 1compartment NA NA Rat Human -DTXSID8047395 Days.Css NA 571 Days PBTK NA NA Rat Human -DTXSID8047395 TK.Half.Life NA 535.7 hours 1compartment NA NA Rat Human -DTXSID8047395 Css NA 0.002396 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047395 Css NA 0.01071 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047395 Css NA 0.2415 mg/L PBTK NA 50% Rat Human -DTXSID8047395 Css NA 1.059 mg/L PBTK NA 95% Rat Human -DTXSID8047397 Clint NA 21.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047397 Fup NA 0.2205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047397 Vd NA 3.289 L/kg 1compartment NA NA Human Human -DTXSID8047397 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047397 TK.Half.Life NA 3.513 hours 1compartment NA NA Human Human -DTXSID8047397 Css NA 0.04884 mg/L 3compartmentss NA 50% Human Human -DTXSID8047397 Css NA 0.392 mg/L 3compartmentss NA 95% Human Human -DTXSID8047397 Css NA 0.05473 mg/L PBTK NA 50% Human Human -DTXSID8047397 Css NA 0.355 mg/L PBTK NA 95% Human Human -DTXSID8047397 Clint NA 21.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047397 Fup NA 0.2205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047397 Vd NA 3.317 L/kg 1compartment NA NA Rat Human +DTXSID8047391 TK.Half.Life NA 1.88 hours 1compartment NA NA Rat Human +DTXSID8047391 Css NA 0.08592 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047391 Css NA 0.5431 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047391 Css NA 0.05206 mg/L PBTK NA 50% Rat Human +DTXSID8047391 Css NA 0.3182 mg/L PBTK NA 95% Rat Human +DTXSID8047397 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047397 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047397 Vd NA 1.741 L/kg 1compartment NA NA Human Human +DTXSID8047397 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8047397 TK.Half.Life NA 24.07 hours 1compartment NA NA Human Human +DTXSID8047397 Css NA 1.19 mg/L 3compartmentss NA 50% Human Human +DTXSID8047397 Css NA 6.645 mg/L 3compartmentss NA 95% Human Human +DTXSID8047397 Css NA 1.119 mg/L PBTK NA 50% Human Human +DTXSID8047397 Css NA 4.569 mg/L PBTK NA 95% Human Human +DTXSID8047397 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047397 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047397 Vd NA 1.749 L/kg 1compartment NA NA Rat Human DTXSID8047397 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047397 TK.Half.Life NA 2.004 hours 1compartment NA NA Rat Human -DTXSID8047397 Css NA 0.02548 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047397 Css NA 0.1654 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047397 Css NA 0.02871 mg/L PBTK NA 50% Rat Human -DTXSID8047397 Css NA 0.1454 mg/L PBTK NA 95% Rat Human -DTXSID8047420 Clint NA 10.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047420 Fup NA 0.3286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047420 Vd NA 1.261 L/kg 1compartment NA NA Human Human +DTXSID8047397 TK.Half.Life NA 8.241 hours 1compartment NA NA Rat Human +DTXSID8047397 Css NA 0.07437 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047397 Css NA 0.3701 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047397 Css NA 0.07058 mg/L PBTK NA 50% Rat Human +DTXSID8047397 Css NA 0.2482 mg/L PBTK NA 95% Rat Human +DTXSID8047399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047399 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047399 Vd NA 2.587 L/kg 1compartment NA NA Human Human +DTXSID8047399 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8047399 TK.Half.Life NA 25.18 hours 1compartment NA NA Human Human +DTXSID8047399 Css NA 1.284 mg/L 3compartmentss NA 50% Human Human +DTXSID8047399 Css NA 8.302 mg/L 3compartmentss NA 95% Human Human +DTXSID8047399 Css NA 0.8603 mg/L PBTK NA 50% Human Human +DTXSID8047399 Css NA 5.4 mg/L PBTK NA 95% Human Human +DTXSID8047399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047399 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047399 Vd NA 1.935 L/kg 1compartment NA NA Rat Human +DTXSID8047399 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8047399 TK.Half.Life NA 5.945 hours 1compartment NA NA Rat Human +DTXSID8047399 Css NA 0.1653 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047399 Css NA 0.9053 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047399 Css NA 0.1091 mg/L PBTK NA 50% Rat Human +DTXSID8047399 Css NA 0.57 mg/L PBTK NA 95% Rat Human +DTXSID8047420 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047420 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047420 Vd NA 0.6018 L/kg 1compartment NA NA Human Human DTXSID8047420 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047420 TK.Half.Life NA 2.309 hours 1compartment NA NA Human Human -DTXSID8047420 Css NA 0.1385 mg/L 3compartmentss NA 50% Human Human -DTXSID8047420 Css NA 0.8851 mg/L 3compartmentss NA 95% Human Human -DTXSID8047420 Css NA 0.106 mg/L PBTK NA 50% Human Human -DTXSID8047420 Css NA 0.613 mg/L PBTK NA 95% Human Human -DTXSID8047420 Clint NA 10.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047420 Fup NA 0.3286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047420 Vd NA 1.051 L/kg 1compartment NA NA Rat Human +DTXSID8047420 TK.Half.Life NA 0.6918 hours 1compartment NA NA Human Human +DTXSID8047420 Css NA 0.05136 mg/L 3compartmentss NA 50% Human Human +DTXSID8047420 Css NA 0.4082 mg/L 3compartmentss NA 95% Human Human +DTXSID8047420 Css NA 0.03753 mg/L PBTK NA 50% Human Human +DTXSID8047420 Css NA 0.271 mg/L PBTK NA 95% Human Human +DTXSID8047420 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047420 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047420 Vd NA 0.5922 L/kg 1compartment NA NA Rat Human DTXSID8047420 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047420 TK.Half.Life NA 1.004 hours 1compartment NA NA Rat Human -DTXSID8047420 Css NA 0.07176 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047420 Css NA 0.3703 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047420 Css NA 0.05274 mg/L PBTK NA 50% Rat Human -DTXSID8047420 Css NA 0.2366 mg/L PBTK NA 95% Rat Human -DTXSID8047428 Clint NA 84.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047428 Fup NA 0.1668 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047428 Vd NA 1.712 L/kg 1compartment NA NA Human Human +DTXSID8047420 TK.Half.Life NA 0.3515 hours 1compartment NA NA Rat Human +DTXSID8047420 Css NA 0.00638 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047420 Css NA 0.03882 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047420 Css NA 0.004674 mg/L PBTK NA 50% Rat Human +DTXSID8047420 Css NA 0.02539 mg/L PBTK NA 95% Rat Human +DTXSID8047426 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047426 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047426 Vd NA 1.652 L/kg 1compartment NA NA Human Human +DTXSID8047426 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047426 TK.Half.Life NA 2.679 hours 1compartment NA NA Human Human +DTXSID8047426 Css NA 0.1038 mg/L 3compartmentss NA 50% Human Human +DTXSID8047426 Css NA 0.7069 mg/L 3compartmentss NA 95% Human Human +DTXSID8047426 Css NA 0.07646 mg/L PBTK NA 50% Human Human +DTXSID8047426 Css NA 0.4828 mg/L PBTK NA 95% Human Human +DTXSID8047426 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047426 Fup 0.243 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047426 Vd NA 1.304 L/kg 1compartment NA NA Rat Human +DTXSID8047426 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047426 TK.Half.Life NA 1.016 hours 1compartment NA NA Rat Human +DTXSID8047426 Css NA 0.01303 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047426 Css NA 0.06826 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047426 Css NA 0.00959 mg/L PBTK NA 50% Rat Human +DTXSID8047426 Css NA 0.04826 mg/L PBTK NA 95% Rat Human +DTXSID8047428 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047428 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047428 Vd NA 1.929 L/kg 1compartment NA NA Human Human DTXSID8047428 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047428 TK.Half.Life NA 1.943 hours 1compartment NA NA Human Human -DTXSID8047428 Css NA 0.04468 mg/L 3compartmentss NA 50% Human Human -DTXSID8047428 Css NA 0.3052 mg/L 3compartmentss NA 95% Human Human -DTXSID8047428 Css NA 0.03192 mg/L PBTK NA 50% Human Human -DTXSID8047428 Css NA 0.2045 mg/L PBTK NA 95% Human Human -DTXSID8047428 Clint NA 84.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047428 Fup NA 0.1668 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047428 Vd NA 1.326 L/kg 1compartment NA NA Rat Human +DTXSID8047428 TK.Half.Life NA 4.677 hours 1compartment NA NA Human Human +DTXSID8047428 Css NA 0.2216 mg/L 3compartmentss NA 50% Human Human +DTXSID8047428 Css NA 1.591 mg/L 3compartmentss NA 95% Human Human +DTXSID8047428 Css NA 0.1543 mg/L PBTK NA 50% Human Human +DTXSID8047428 Css NA 1.06 mg/L PBTK NA 95% Human Human +DTXSID8047428 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047428 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047428 Vd NA 1.478 L/kg 1compartment NA NA Rat Human DTXSID8047428 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047428 TK.Half.Life NA 0.689 hours 1compartment NA NA Rat Human -DTXSID8047428 Css NA 0.02504 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047428 Css NA 0.137 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047428 Css NA 0.01683 mg/L PBTK NA 50% Rat Human -DTXSID8047428 Css NA 0.09079 mg/L PBTK NA 95% Rat Human -DTXSID8047470 Clint NA 106.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047470 Fup NA 0.2896 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047470 Vd NA 1.408 L/kg 1compartment NA NA Human Human -DTXSID8047470 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047470 TK.Half.Life NA 1.22 hours 1compartment NA NA Human Human -DTXSID8047470 Css NA 0.01725 mg/L 3compartmentss NA 50% Human Human -DTXSID8047470 Css NA 0.1245 mg/L 3compartmentss NA 95% Human Human -DTXSID8047470 Css NA 0.01296 mg/L PBTK NA 50% Human Human -DTXSID8047470 Css NA 0.0859 mg/L PBTK NA 95% Human Human -DTXSID8047470 Clint NA 106.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047470 Fup NA 0.2896 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047470 Vd NA 1.145 L/kg 1compartment NA NA Rat Human -DTXSID8047470 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047470 TK.Half.Life NA 0.4524 hours 1compartment NA NA Rat Human -DTXSID8047470 Css NA 0.009508 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047470 Css NA 0.05829 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047470 Css NA 0.006885 mg/L PBTK NA 50% Rat Human -DTXSID8047470 Css NA 0.03836 mg/L PBTK NA 95% Rat Human -DTXSID8047501 Clint NA 931.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047501 Fup NA 0.0403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047501 Vd NA 3.05 L/kg 1compartment NA NA Human Human -DTXSID8047501 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047501 TK.Half.Life NA 3.729 hours 1compartment NA NA Human Human -DTXSID8047501 Css NA 0.05176 mg/L 3compartmentss NA 50% Human Human -DTXSID8047501 Css NA 0.3428 mg/L 3compartmentss NA 95% Human Human -DTXSID8047501 Css NA 0.03581 mg/L PBTK NA 50% Human Human -DTXSID8047501 Css NA 0.2293 mg/L PBTK NA 95% Human Human -DTXSID8047501 Clint NA 931.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047501 Fup NA 0.0403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047501 Vd NA 2.286 L/kg 1compartment NA NA Rat Human -DTXSID8047501 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047501 TK.Half.Life NA 0.9978 hours 1compartment NA NA Rat Human -DTXSID8047501 Css NA 0.0293 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047501 Css NA 0.1576 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047501 Css NA 0.01934 mg/L PBTK NA 50% Rat Human -DTXSID8047501 Css NA 0.1008 mg/L PBTK NA 95% Rat Human +DTXSID8047428 TK.Half.Life NA 1.615 hours 1compartment NA NA Rat Human +DTXSID8047428 Css NA 0.02858 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047428 Css NA 0.164 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047428 Css NA 0.01971 mg/L PBTK NA 50% Rat Human +DTXSID8047428 Css NA 0.1057 mg/L PBTK NA 95% Rat Human +DTXSID8047474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047474 Fup 0.0461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047474 Vd NA 2.451 L/kg 1compartment NA NA Human Human +DTXSID8047474 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8047474 TK.Half.Life NA 17.75 hours 1compartment NA NA Human Human +DTXSID8047474 Css NA 0.9253 mg/L 3compartmentss NA 50% Human Human +DTXSID8047474 Css NA 6.152 mg/L 3compartmentss NA 95% Human Human +DTXSID8047474 Css NA 0.6152 mg/L PBTK NA 50% Human Human +DTXSID8047474 Css NA 3.958 mg/L PBTK NA 95% Human Human +DTXSID8047474 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047474 Fup 0.0461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047474 Vd NA 1.835 L/kg 1compartment NA NA Rat Human +DTXSID8047474 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047474 TK.Half.Life NA 4.624 hours 1compartment NA NA Rat Human +DTXSID8047474 Css NA 0.119 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047474 Css NA 0.6365 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047474 Css NA 0.0786 mg/L PBTK NA 50% Rat Human +DTXSID8047474 Css NA 0.4136 mg/L PBTK NA 95% Rat Human DTXSID8047505 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8047505 Fup NA 0.0457 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047505 Vd NA 2.42 L/kg 1compartment NA NA Human Human -DTXSID8047505 Days.Css NA 249 Days PBTK NA NA Human Human -DTXSID8047505 TK.Half.Life NA 980.4 hours 1compartment NA NA Human Human -DTXSID8047505 Css NA 54.35 mg/L 3compartmentss NA 50% Human Human -DTXSID8047505 Css NA 174.8 mg/L 3compartmentss NA 95% Human Human -DTXSID8047505 Css NA 36.54 mg/L PBTK NA 50% Human Human -DTXSID8047505 Css NA 108 mg/L PBTK NA 95% Human Human +DTXSID8047505 Vd NA 0.2361 L/kg 1compartment NA NA Human Human +DTXSID8047505 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID8047505 TK.Half.Life NA 33.47 hours 1compartment NA NA Human Human +DTXSID8047505 Css NA 12.88 mg/L 3compartmentss NA 50% Human Human +DTXSID8047505 Css NA 61.53 mg/L 3compartmentss NA 95% Human Human +DTXSID8047505 Css NA 7.637 mg/L PBTK NA 50% Human Human +DTXSID8047505 Css NA 35.21 mg/L PBTK NA 95% Human Human DTXSID8047505 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8047505 Fup NA 0.0457 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047505 Vd NA 1.816 L/kg 1compartment NA NA Rat Human -DTXSID8047505 Days.Css NA 60 Days PBTK NA NA Rat Human -DTXSID8047505 TK.Half.Life NA 126.5 hours 1compartment NA NA Rat Human -DTXSID8047505 Css NA 14.86 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047505 Css NA 39.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047505 Css NA 9.456 mg/L PBTK NA 50% Rat Human -DTXSID8047505 Css NA 23.01 mg/L PBTK NA 95% Rat Human -DTXSID8047551 Clint NA 0.03077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047551 Fup NA 0.2443 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047551 Vd NA 2.571 L/kg 1compartment NA NA Human Human -DTXSID8047551 Days.Css NA 41 Days PBTK NA NA Human Human -DTXSID8047551 TK.Half.Life NA 200.7 hours 1compartment NA NA Human Human -DTXSID8047551 Css NA 8.572 mg/L 3compartmentss NA 50% Human Human -DTXSID8047551 Css NA 25.07 mg/L 3compartmentss NA 95% Human Human -DTXSID8047551 Css NA 6.341 mg/L PBTK NA 50% Human Human -DTXSID8047551 Css NA 16.91 mg/L PBTK NA 95% Human Human -DTXSID8047551 Clint NA 0.03077 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047551 Fup NA 0.2443 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047551 Vd NA 1.963 L/kg 1compartment NA NA Rat Human -DTXSID8047551 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID8047551 TK.Half.Life NA 25.93 hours 1compartment NA NA Rat Human -DTXSID8047551 Css NA 2.425 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047551 Css NA 5.776 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047551 Css NA 1.716 mg/L PBTK NA 50% Rat Human -DTXSID8047551 Css NA 3.584 mg/L PBTK NA 95% Rat Human -DTXSID8047553 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID8047553 Fup 8.05e-09 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8047553 Vd NA 0.1603 L/kg 1compartment NA NA Human Human -DTXSID8047553 Days.Css NA 3255 Days PBTK NA NA Human Human -DTXSID8047553 TK.Half.Life NA 10370 hours 1compartment NA NA Human Human -DTXSID8047553 Css NA 5759 mg/L 3compartmentss NA 50% Human Human -DTXSID8047553 Css NA 14040 mg/L 3compartmentss NA 95% Human Human -DTXSID8047553 Css NA 3372 mg/L PBTK NA 50% Human Human -DTXSID8047553 Css NA 7918 mg/L PBTK NA 95% Human Human -DTXSID8047553 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID8047553 Fup 8.05e-09 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8047553 Vd NA 0.1586 L/kg 1compartment NA NA Rat Human -DTXSID8047553 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID8047553 TK.Half.Life NA 3497 hours 1compartment NA NA Rat Human -DTXSID8047553 Css NA 1929 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047553 Css NA 2453 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047553 Css NA 1042 mg/L PBTK NA 50% Rat Human -DTXSID8047553 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID8047630 Clint NA 372 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047630 Fup NA 0.5634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047630 Vd NA 2.212 L/kg 1compartment NA NA Human Human -DTXSID8047630 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047630 TK.Half.Life NA 1.159 hours 1compartment NA NA Human Human -DTXSID8047630 Css NA 0.001821 mg/L 3compartmentss NA 50% Human Human -DTXSID8047630 Css NA 0.02272 mg/L 3compartmentss NA 95% Human Human -DTXSID8047630 Css NA 0.001828 mg/L PBTK NA 50% Human Human -DTXSID8047630 Css NA 0.01746 mg/L PBTK NA 95% Human Human -DTXSID8047630 Clint NA 372 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047630 Fup NA 0.5634 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047630 Vd NA 2.239 L/kg 1compartment NA NA Rat Human -DTXSID8047630 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047630 TK.Half.Life NA 0.5177 hours 1compartment NA NA Rat Human -DTXSID8047630 Css NA 0.0009594 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047630 Css NA 0.0108 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047630 Css NA 0.0009469 mg/L PBTK NA 50% Rat Human -DTXSID8047630 Css NA 0.008093 mg/L PBTK NA 95% Rat Human -DTXSID8047680 Clint NA 1.915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047680 Fup NA 0.7617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047680 Vd NA 1.378 L/kg 1compartment NA NA Human Human +DTXSID8047505 Vd NA 0.2251 L/kg 1compartment NA NA Rat Human +DTXSID8047505 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8047505 TK.Half.Life NA 10.87 hours 1compartment NA NA Rat Human +DTXSID8047505 Css NA 0.07084 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047505 Css NA 0.325 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047505 Css NA 0.03956 mg/L PBTK NA 50% Rat Human +DTXSID8047505 Css NA 0.1783 mg/L PBTK NA 95% Rat Human +DTXSID8047551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047551 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047551 Vd NA 2.39 L/kg 1compartment NA NA Human Human +DTXSID8047551 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047551 TK.Half.Life NA 5.691 hours 1compartment NA NA Human Human +DTXSID8047551 Css NA 0.1908 mg/L 3compartmentss NA 50% Human Human +DTXSID8047551 Css NA 1.215 mg/L 3compartmentss NA 95% Human Human +DTXSID8047551 Css NA 0.1381 mg/L PBTK NA 50% Human Human +DTXSID8047551 Css NA 0.8456 mg/L PBTK NA 95% Human Human +DTXSID8047551 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047551 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047551 Vd NA 1.827 L/kg 1compartment NA NA Rat Human +DTXSID8047551 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047551 TK.Half.Life NA 1.674 hours 1compartment NA NA Rat Human +DTXSID8047551 Css NA 0.02419 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047551 Css NA 0.1193 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047551 Css NA 0.01756 mg/L PBTK NA 50% Rat Human +DTXSID8047551 Css NA 0.08421 mg/L PBTK NA 95% Rat Human +DTXSID8047680 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047680 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047680 Vd NA 0.8631 L/kg 1compartment NA NA Human Human DTXSID8047680 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047680 TK.Half.Life NA 3.508 hours 1compartment NA NA Human Human -DTXSID8047680 Css NA 0.2433 mg/L 3compartmentss NA 50% Human Human -DTXSID8047680 Css NA 1.719 mg/L 3compartmentss NA 95% Human Human -DTXSID8047680 Css NA 0.2184 mg/L PBTK NA 50% Human Human -DTXSID8047680 Css NA 1.198 mg/L PBTK NA 95% Human Human -DTXSID8047680 Clint NA 1.915 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047680 Fup NA 0.7617 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047680 Vd NA 1.243 L/kg 1compartment NA NA Rat Human +DTXSID8047680 TK.Half.Life NA 1.256 hours 1compartment NA NA Human Human +DTXSID8047680 Css NA 0.08464 mg/L 3compartmentss NA 50% Human Human +DTXSID8047680 Css NA 0.6013 mg/L 3compartmentss NA 95% Human Human +DTXSID8047680 Css NA 0.06056 mg/L PBTK NA 50% Human Human +DTXSID8047680 Css NA 0.3977 mg/L PBTK NA 95% Human Human +DTXSID8047680 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047680 Fup 0.248 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047680 Vd NA 0.7453 L/kg 1compartment NA NA Rat Human DTXSID8047680 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047680 TK.Half.Life NA 1.545 hours 1compartment NA NA Rat Human -DTXSID8047680 Css NA 0.1015 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047680 Css NA 0.7387 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047680 Css NA 0.08999 mg/L PBTK NA 50% Rat Human -DTXSID8047680 Css NA 0.4519 mg/L PBTK NA 95% Rat Human -DTXSID8047686 Clint NA 7.248 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047686 Fup NA 0.0578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047686 Vd NA 2.772 L/kg 1compartment NA NA Human Human -DTXSID8047686 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID8047686 TK.Half.Life NA 64.3 hours 1compartment NA NA Human Human -DTXSID8047686 Css NA 3.02 mg/L 3compartmentss NA 50% Human Human -DTXSID8047686 Css NA 18.07 mg/L 3compartmentss NA 95% Human Human -DTXSID8047686 Css NA 2.071 mg/L PBTK NA 50% Human Human -DTXSID8047686 Css NA 11.91 mg/L PBTK NA 95% Human Human -DTXSID8047686 Clint NA 7.248 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047686 Fup NA 0.0578 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047686 Vd NA 2.079 L/kg 1compartment NA NA Rat Human -DTXSID8047686 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID8047686 TK.Half.Life NA 12.6 hours 1compartment NA NA Rat Human -DTXSID8047686 Css NA 1.66 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047686 Css NA 7.129 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047686 Css NA 1.082 mg/L PBTK NA 50% Rat Human -DTXSID8047686 Css NA 4.429 mg/L PBTK NA 95% Rat Human -DTXSID8047711 Clint NA 5592 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047711 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047711 Vd NA 533300 L/kg 1compartment NA NA Human Human -DTXSID8047711 Days.Css NA 13780 Days PBTK NA NA Human Human -DTXSID8047711 TK.Half.Life NA 62390 hours 1compartment NA NA Human Human -DTXSID8047711 Css NA 8.9e-08 mg/L 3compartmentss NA 50% Human Human -DTXSID8047711 Css NA 5.58e-07 mg/L 3compartmentss NA 95% Human Human -DTXSID8047711 Css NA 0.009709 mg/L PBTK NA 50% Human Human -DTXSID8047711 Css NA 0.05416 mg/L PBTK NA 95% Human Human -DTXSID8047711 Clint NA 5592 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047711 Fup NA 0.0041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047711 Vd NA 509100 L/kg 1compartment NA NA Rat Human -DTXSID8047711 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID8047711 TK.Half.Life NA 11000 hours 1compartment NA NA Rat Human -DTXSID8047711 Css NA 4.6e-08 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047711 Css NA 2.01e-07 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047711 Css NA 0.005282 mg/L PBTK NA 50% Rat Human -DTXSID8047711 Css NA 0.02324 mg/L PBTK NA 95% Rat Human -DTXSID8047713 Clint NA 112.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047713 Fup NA 0.1781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047713 Vd NA 1.747 L/kg 1compartment NA NA Human Human +DTXSID8047680 TK.Half.Life NA 0.5762 hours 1compartment NA NA Rat Human +DTXSID8047680 Css NA 0.01068 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047680 Css NA 0.05992 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047680 Css NA 0.007521 mg/L PBTK NA 50% Rat Human +DTXSID8047680 Css NA 0.03843 mg/L PBTK NA 95% Rat Human +DTXSID8047684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047684 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047684 Vd NA 2.239 L/kg 1compartment NA NA Human Human +DTXSID8047684 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8047684 TK.Half.Life NA 15.88 hours 1compartment NA NA Human Human +DTXSID8047684 Css NA 0.9604 mg/L 3compartmentss NA 50% Human Human +DTXSID8047684 Css NA 7.52 mg/L 3compartmentss NA 95% Human Human +DTXSID8047684 Css NA 0.6334 mg/L PBTK NA 50% Human Human +DTXSID8047684 Css NA 4.751 mg/L PBTK NA 95% Human Human +DTXSID8047684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047684 Fup 0.0395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047684 Vd NA 1.674 L/kg 1compartment NA NA Rat Human +DTXSID8047684 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047684 TK.Half.Life NA 4.633 hours 1compartment NA NA Rat Human +DTXSID8047684 Css NA 0.125 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047684 Css NA 0.77 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047684 Css NA 0.0807 mg/L PBTK NA 50% Rat Human +DTXSID8047684 Css NA 0.474 mg/L PBTK NA 95% Rat Human +DTXSID8047686 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047686 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047686 Vd NA 0.5128 L/kg 1compartment NA NA Human Human +DTXSID8047686 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8047686 TK.Half.Life NA 12.95 hours 1compartment NA NA Human Human +DTXSID8047686 Css NA 2.904 mg/L 3compartmentss NA 50% Human Human +DTXSID8047686 Css NA 10.91 mg/L 3compartmentss NA 95% Human Human +DTXSID8047686 Css NA 2.003 mg/L PBTK NA 50% Human Human +DTXSID8047686 Css NA 6.908 mg/L PBTK NA 95% Human Human +DTXSID8047686 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047686 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047686 Vd NA 0.4969 L/kg 1compartment NA NA Rat Human +DTXSID8047686 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047686 TK.Half.Life NA 4.252 hours 1compartment NA NA Rat Human +DTXSID8047686 Css NA 0.1868 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047686 Css NA 0.6079 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047686 Css NA 0.1268 mg/L PBTK NA 50% Rat Human +DTXSID8047686 Css NA 0.3652 mg/L PBTK NA 95% Rat Human +DTXSID8047713 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047713 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047713 Vd NA 1.95 L/kg 1compartment NA NA Human Human DTXSID8047713 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047713 TK.Half.Life NA 1.798 hours 1compartment NA NA Human Human -DTXSID8047713 Css NA 0.03191 mg/L 3compartmentss NA 50% Human Human -DTXSID8047713 Css NA 0.2206 mg/L 3compartmentss NA 95% Human Human -DTXSID8047713 Css NA 0.02266 mg/L PBTK NA 50% Human Human -DTXSID8047713 Css NA 0.1517 mg/L PBTK NA 95% Human Human -DTXSID8047713 Clint NA 112.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047713 Fup NA 0.1781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047713 Vd NA 1.353 L/kg 1compartment NA NA Rat Human +DTXSID8047713 TK.Half.Life NA 3.741 hours 1compartment NA NA Human Human +DTXSID8047713 Css NA 0.1385 mg/L 3compartmentss NA 50% Human Human +DTXSID8047713 Css NA 0.9307 mg/L 3compartmentss NA 95% Human Human +DTXSID8047713 Css NA 0.1009 mg/L PBTK NA 50% Human Human +DTXSID8047713 Css NA 0.6282 mg/L PBTK NA 95% Human Human +DTXSID8047713 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047713 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047713 Vd NA 1.51 L/kg 1compartment NA NA Rat Human DTXSID8047713 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047713 TK.Half.Life NA 0.6284 hours 1compartment NA NA Rat Human -DTXSID8047713 Css NA 0.01776 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047713 Css NA 0.09862 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047713 Css NA 0.01215 mg/L PBTK NA 50% Rat Human -DTXSID8047713 Css NA 0.06391 mg/L PBTK NA 95% Rat Human -DTXSID8047717 Clint NA 31.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047717 Fup NA 0.1139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047717 Vd NA 2.948 L/kg 1compartment NA NA Human Human -DTXSID8047717 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8047717 TK.Half.Life NA 16.35 hours 1compartment NA NA Human Human -DTXSID8047717 Css NA 0.6197 mg/L 3compartmentss NA 50% Human Human -DTXSID8047717 Css NA 3.906 mg/L 3compartmentss NA 95% Human Human -DTXSID8047717 Css NA 0.4302 mg/L PBTK NA 50% Human Human -DTXSID8047717 Css NA 2.611 mg/L PBTK NA 95% Human Human -DTXSID8047717 Clint NA 31.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047717 Fup NA 0.1139 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047717 Vd NA 2.216 L/kg 1compartment NA NA Rat Human +DTXSID8047713 TK.Half.Life NA 1.3 hours 1compartment NA NA Rat Human +DTXSID8047713 Css NA 0.01738 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047713 Css NA 0.08936 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047713 Css NA 0.0126 mg/L PBTK NA 50% Rat Human +DTXSID8047713 Css NA 0.06222 mg/L PBTK NA 95% Rat Human +DTXSID8047717 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047717 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047717 Vd NA 1.915 L/kg 1compartment NA NA Human Human +DTXSID8047717 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047717 TK.Half.Life NA 4.621 hours 1compartment NA NA Human Human +DTXSID8047717 Css NA 0.2199 mg/L 3compartmentss NA 50% Human Human +DTXSID8047717 Css NA 1.582 mg/L 3compartmentss NA 95% Human Human +DTXSID8047717 Css NA 0.1532 mg/L PBTK NA 50% Human Human +DTXSID8047717 Css NA 1.055 mg/L PBTK NA 95% Human Human +DTXSID8047717 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047717 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047717 Vd NA 1.467 L/kg 1compartment NA NA Rat Human DTXSID8047717 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047717 TK.Half.Life NA 3.088 hours 1compartment NA NA Rat Human -DTXSID8047717 Css NA 0.343 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047717 Css NA 1.721 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047717 Css NA 0.2286 mg/L PBTK NA 50% Rat Human -DTXSID8047717 Css NA 1.11 mg/L PBTK NA 95% Rat Human -DTXSID8047840 Clint NA 239.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047840 Fup NA 0.374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047840 Vd NA 2.859 L/kg 1compartment NA NA Human Human +DTXSID8047717 TK.Half.Life NA 1.6 hours 1compartment NA NA Rat Human +DTXSID8047717 Css NA 0.0284 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047717 Css NA 0.1637 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047717 Css NA 0.01957 mg/L PBTK NA 50% Rat Human +DTXSID8047717 Css NA 0.1051 mg/L PBTK NA 95% Rat Human +DTXSID8047840 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047840 Fup 0.582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047840 Vd NA 1.43 L/kg 1compartment NA NA Human Human DTXSID8047840 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047840 TK.Half.Life NA 1.349 hours 1compartment NA NA Human Human -DTXSID8047840 Css NA 0.00269 mg/L 3compartmentss NA 50% Human Human -DTXSID8047840 Css NA 0.02741 mg/L 3compartmentss NA 95% Human Human -DTXSID8047840 Css NA 0.003233 mg/L PBTK NA 50% Human Human -DTXSID8047840 Css NA 0.02512 mg/L PBTK NA 95% Human Human -DTXSID8047840 Clint NA 239.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047840 Fup NA 0.374 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047840 Vd NA 2.833 L/kg 1compartment NA NA Rat Human +DTXSID8047840 TK.Half.Life NA 2.066 hours 1compartment NA NA Human Human +DTXSID8047840 Css NA 0.09954 mg/L 3compartmentss NA 50% Human Human +DTXSID8047840 Css NA 0.9763 mg/L 3compartmentss NA 95% Human Human +DTXSID8047840 Css NA 0.09092 mg/L PBTK NA 50% Human Human +DTXSID8047840 Css NA 0.6859 mg/L PBTK NA 95% Human Human +DTXSID8047840 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047840 Fup 0.582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047840 Vd NA 1.415 L/kg 1compartment NA NA Rat Human DTXSID8047840 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047840 TK.Half.Life NA 0.607 hours 1compartment NA NA Rat Human -DTXSID8047840 Css NA 0.001428 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047840 Css NA 0.01195 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047840 Css NA 0.001721 mg/L PBTK NA 50% Rat Human -DTXSID8047840 Css NA 0.01082 mg/L PBTK NA 95% Rat Human -DTXSID8047842 Clint NA 13.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047842 Fup NA 0.4449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047842 Vd NA 0.3708 L/kg 1compartment NA NA Human Human +DTXSID8047840 TK.Half.Life NA 1.128 hours 1compartment NA NA Rat Human +DTXSID8047840 Css NA 0.01109 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047840 Css NA 0.0979 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047840 Css NA 0.01031 mg/L PBTK NA 50% Rat Human +DTXSID8047840 Css NA 0.06487 mg/L PBTK NA 95% Rat Human +DTXSID8047842 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047842 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047842 Vd NA 0.4552 L/kg 1compartment NA NA Human Human DTXSID8047842 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047842 TK.Half.Life NA 0.5019 hours 1compartment NA NA Human Human -DTXSID8047842 Css NA 0.08281 mg/L 3compartmentss NA 50% Human Human -DTXSID8047842 Css NA 0.6074 mg/L 3compartmentss NA 95% Human Human -DTXSID8047842 Css NA 0.05695 mg/L PBTK NA 50% Human Human -DTXSID8047842 Css NA 0.3904 mg/L PBTK NA 95% Human Human -DTXSID8047842 Clint NA 13.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047842 Fup NA 0.4449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047842 Vd NA 0.3828 L/kg 1compartment NA NA Rat Human +DTXSID8047842 TK.Half.Life NA 0.9882 hours 1compartment NA NA Human Human +DTXSID8047842 Css NA 0.1861 mg/L 3compartmentss NA 50% Human Human +DTXSID8047842 Css NA 1.15 mg/L 3compartmentss NA 95% Human Human +DTXSID8047842 Css NA 0.1296 mg/L PBTK NA 50% Human Human +DTXSID8047842 Css NA 0.7423 mg/L PBTK NA 95% Human Human +DTXSID8047842 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047842 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047842 Vd NA 0.4466 L/kg 1compartment NA NA Rat Human DTXSID8047842 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047842 TK.Half.Life NA 0.2722 hours 1compartment NA NA Rat Human -DTXSID8047842 Css NA 0.04351 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047842 Css NA 0.2482 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047842 Css NA 0.02845 mg/L PBTK NA 50% Rat Human -DTXSID8047842 Css NA 0.1474 mg/L PBTK NA 95% Rat Human -DTXSID8047844 Clint NA 11.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047844 Fup NA 0.1938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047844 Vd NA 2.947 L/kg 1compartment NA NA Human Human -DTXSID8047844 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8047844 TK.Half.Life NA 24.2 hours 1compartment NA NA Human Human -DTXSID8047844 Css NA 0.898 mg/L 3compartmentss NA 50% Human Human -DTXSID8047844 Css NA 5.156 mg/L 3compartmentss NA 95% Human Human -DTXSID8047844 Css NA 0.6449 mg/L PBTK NA 50% Human Human -DTXSID8047844 Css NA 3.6 mg/L PBTK NA 95% Human Human -DTXSID8047844 Clint NA 11.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047844 Fup NA 0.1938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047844 Vd NA 2.238 L/kg 1compartment NA NA Rat Human -DTXSID8047844 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8047844 TK.Half.Life NA 4.551 hours 1compartment NA NA Rat Human -DTXSID8047844 Css NA 0.4867 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047844 Css NA 2.185 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047844 Css NA 0.3357 mg/L PBTK NA 50% Rat Human -DTXSID8047844 Css NA 1.456 mg/L PBTK NA 95% Rat Human -DTXSID8047846 Clint NA 11.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047846 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047846 Vd NA 0.8169 L/kg 1compartment NA NA Human Human +DTXSID8047842 TK.Half.Life NA 0.5411 hours 1compartment NA NA Rat Human +DTXSID8047842 Css NA 0.02139 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047842 Css NA 0.1058 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047842 Css NA 0.0148 mg/L PBTK NA 50% Rat Human +DTXSID8047842 Css NA 0.06505 mg/L PBTK NA 95% Rat Human +DTXSID8047844 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047844 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047844 Vd NA 2.55 L/kg 1compartment NA NA Human Human +DTXSID8047844 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047844 TK.Half.Life NA 5.377 hours 1compartment NA NA Human Human +DTXSID8047844 Css NA 0.1583 mg/L 3compartmentss NA 50% Human Human +DTXSID8047844 Css NA 1.052 mg/L 3compartmentss NA 95% Human Human +DTXSID8047844 Css NA 0.1189 mg/L PBTK NA 50% Human Human +DTXSID8047844 Css NA 0.75 mg/L PBTK NA 95% Human Human +DTXSID8047844 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047844 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047844 Vd NA 1.985 L/kg 1compartment NA NA Rat Human +DTXSID8047844 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047844 TK.Half.Life NA 1.581 hours 1compartment NA NA Rat Human +DTXSID8047844 Css NA 0.01987 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047844 Css NA 0.1012 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047844 Css NA 0.01493 mg/L PBTK NA 50% Rat Human +DTXSID8047844 Css NA 0.0733 mg/L PBTK NA 95% Rat Human +DTXSID8047846 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047846 Fup 0.0657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047846 Vd NA 1.115 L/kg 1compartment NA NA Human Human DTXSID8047846 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047846 TK.Half.Life NA 6.359 hours 1compartment NA NA Human Human -DTXSID8047846 Css NA 1.227 mg/L 3compartmentss NA 50% Human Human -DTXSID8047846 Css NA 8.569 mg/L 3compartmentss NA 95% Human Human -DTXSID8047846 Css NA 0.7594 mg/L PBTK NA 50% Human Human -DTXSID8047846 Css NA 5.147 mg/L PBTK NA 95% Human Human -DTXSID8047846 Clint NA 11.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047846 Fup NA 0.0464 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047846 Vd NA 0.6617 L/kg 1compartment NA NA Rat Human +DTXSID8047846 TK.Half.Life NA 10.71 hours 1compartment NA NA Human Human +DTXSID8047846 Css NA 1.332 mg/L 3compartmentss NA 50% Human Human +DTXSID8047846 Css NA 8.088 mg/L 3compartmentss NA 95% Human Human +DTXSID8047846 Css NA 0.8596 mg/L PBTK NA 50% Human Human +DTXSID8047846 Css NA 5.025 mg/L PBTK NA 95% Human Human +DTXSID8047846 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047846 Fup 0.0657 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047846 Vd NA 0.894 L/kg 1compartment NA NA Rat Human DTXSID8047846 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047846 TK.Half.Life NA 3.127 hours 1compartment NA NA Rat Human -DTXSID8047846 Css NA 0.6879 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047846 Css NA 3.677 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047846 Css NA 0.3976 mg/L PBTK NA 50% Rat Human -DTXSID8047846 Css NA 2.052 mg/L PBTK NA 95% Rat Human -DTXSID8047848 Clint NA 3.771 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047848 Fup NA 0.3857 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047848 Vd NA 3.457 L/kg 1compartment NA NA Human Human +DTXSID8047846 TK.Half.Life NA 4.861 hours 1compartment NA NA Rat Human +DTXSID8047846 Css NA 0.1654 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047846 Css NA 0.7386 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047846 Css NA 0.1039 mg/L PBTK NA 50% Rat Human +DTXSID8047846 Css NA 0.4369 mg/L PBTK NA 95% Rat Human +DTXSID8047848 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047848 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047848 Vd NA 0.9355 L/kg 1compartment NA NA Human Human DTXSID8047848 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047848 TK.Half.Life NA 8.961 hours 1compartment NA NA Human Human -DTXSID8047848 Css NA 0.1681 mg/L 3compartmentss NA 50% Human Human -DTXSID8047848 Css NA 1.178 mg/L 3compartmentss NA 95% Human Human -DTXSID8047848 Css NA 0.1973 mg/L PBTK NA 50% Human Human -DTXSID8047848 Css NA 1.062 mg/L PBTK NA 95% Human Human -DTXSID8047848 Clint NA 3.771 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047848 Fup NA 0.3857 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047848 Vd NA 3.484 L/kg 1compartment NA NA Rat Human +DTXSID8047848 TK.Half.Life NA 2.015 hours 1compartment NA NA Human Human +DTXSID8047848 Css NA 0.1703 mg/L 3compartmentss NA 50% Human Human +DTXSID8047848 Css NA 1.177 mg/L 3compartmentss NA 95% Human Human +DTXSID8047848 Css NA 0.1318 mg/L PBTK NA 50% Human Human +DTXSID8047848 Css NA 0.7981 mg/L PBTK NA 95% Human Human +DTXSID8047848 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047848 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047848 Vd NA 0.9514 L/kg 1compartment NA NA Rat Human DTXSID8047848 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047848 TK.Half.Life NA 5.041 hours 1compartment NA NA Rat Human -DTXSID8047848 Css NA 0.07954 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047848 Css NA 0.4306 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047848 Css NA 0.09322 mg/L PBTK NA 50% Rat Human -DTXSID8047848 Css NA 0.3491 mg/L PBTK NA 95% Rat Human +DTXSID8047848 TK.Half.Life NA 1.163 hours 1compartment NA NA Rat Human +DTXSID8047848 Css NA 0.01996 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047848 Css NA 0.1002 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047848 Css NA 0.01546 mg/L PBTK NA 50% Rat Human +DTXSID8047848 Css NA 0.06507 mg/L PBTK NA 95% Rat Human DTXSID8047890 Clint 191 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID8047890 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047890 Vd NA 2.189 L/kg 1compartment NA NA Human Human +DTXSID8047890 Fup 0.00948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047890 Vd NA 1.939 L/kg 1compartment NA NA Human Human DTXSID8047890 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047890 TK.Half.Life NA 4.101 hours 1compartment NA NA Human Human -DTXSID8047890 Css NA 0.1688 mg/L 3compartmentss NA 50% Human Human -DTXSID8047890 Css NA 2.001 mg/L 3compartmentss NA 95% Human Human -DTXSID8047890 Css NA 0.1108 mg/L PBTK NA 50% Human Human -DTXSID8047890 Css NA 1.23 mg/L PBTK NA 95% Human Human +DTXSID8047890 TK.Half.Life NA 5.097 hours 1compartment NA NA Human Human +DTXSID8047890 Css NA 0.2938 mg/L 3compartmentss NA 50% Human Human +DTXSID8047890 Css NA 3.882 mg/L 3compartmentss NA 95% Human Human +DTXSID8047890 Css NA 0.1869 mg/L PBTK NA 50% Human Human +DTXSID8047890 Css NA 2.394 mg/L PBTK NA 95% Human Human DTXSID8047890 Clint 191 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID8047890 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047890 Vd NA 1.63 L/kg 1compartment NA NA Rat Human +DTXSID8047890 Fup 0.00948 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047890 Vd NA 1.435 L/kg 1compartment NA NA Rat Human DTXSID8047890 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047890 TK.Half.Life NA 1.272 hours 1compartment NA NA Rat Human -DTXSID8047890 Css NA 0.09826 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047890 Css NA 1.005 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047890 Css NA 0.06078 mg/L PBTK NA 50% Rat Human -DTXSID8047890 Css NA 0.5923 mg/L PBTK NA 95% Rat Human -DTXSID8047894 Clint NA 25.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047894 Fup NA 0.0345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047894 Vd NA 1.433 L/kg 1compartment NA NA Human Human +DTXSID8047890 TK.Half.Life NA 1.679 hours 1compartment NA NA Rat Human +DTXSID8047890 Css NA 0.03942 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047890 Css NA 0.4336 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047890 Css NA 0.02454 mg/L PBTK NA 50% Rat Human +DTXSID8047890 Css NA 0.2597 mg/L PBTK NA 95% Rat Human +DTXSID8047894 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047894 Fup 0.0307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047894 Vd NA 0.7234 L/kg 1compartment NA NA Human Human DTXSID8047894 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047894 TK.Half.Life NA 7.76 hours 1compartment NA NA Human Human -DTXSID8047894 Css NA 0.8086 mg/L 3compartmentss NA 50% Human Human -DTXSID8047894 Css NA 5.87 mg/L 3compartmentss NA 95% Human Human -DTXSID8047894 Css NA 0.5075 mg/L PBTK NA 50% Human Human -DTXSID8047894 Css NA 3.556 mg/L PBTK NA 95% Human Human -DTXSID8047894 Clint NA 25.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047894 Fup NA 0.0345 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047894 Vd NA 1.068 L/kg 1compartment NA NA Rat Human +DTXSID8047894 TK.Half.Life NA 4.533 hours 1compartment NA NA Human Human +DTXSID8047894 Css NA 0.9746 mg/L 3compartmentss NA 50% Human Human +DTXSID8047894 Css NA 9.222 mg/L 3compartmentss NA 95% Human Human +DTXSID8047894 Css NA 0.5906 mg/L PBTK NA 50% Human Human +DTXSID8047894 Css NA 5.465 mg/L PBTK NA 95% Human Human +DTXSID8047894 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047894 Fup 0.0307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047894 Vd NA 0.5513 L/kg 1compartment NA NA Rat Human DTXSID8047894 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047894 TK.Half.Life NA 3.029 hours 1compartment NA NA Rat Human -DTXSID8047894 Css NA 0.4522 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047894 Css NA 2.628 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047894 Css NA 0.2656 mg/L PBTK NA 50% Rat Human -DTXSID8047894 Css NA 1.504 mg/L PBTK NA 95% Rat Human -DTXSID8047896 Clint NA 10.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047896 Fup NA 0.0438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047896 Vd NA 3.488 L/kg 1compartment NA NA Human Human -DTXSID8047896 Days.Css NA 43 Days PBTK NA NA Human Human -DTXSID8047896 TK.Half.Life NA 215.9 hours 1compartment NA NA Human Human -DTXSID8047896 Css NA 6.986 mg/L 3compartmentss NA 50% Human Human -DTXSID8047896 Css NA 39.72 mg/L 3compartmentss NA 95% Human Human -DTXSID8047896 Css NA 5.026 mg/L PBTK NA 50% Human Human -DTXSID8047896 Css NA 28.45 mg/L PBTK NA 95% Human Human -DTXSID8047896 Clint NA 10.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047896 Fup NA 0.0438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047896 Vd NA 2.625 L/kg 1compartment NA NA Rat Human -DTXSID8047896 Days.Css NA 24 Days PBTK NA NA Rat Human -DTXSID8047896 TK.Half.Life NA 27.98 hours 1compartment NA NA Rat Human -DTXSID8047896 Css NA 3.977 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047896 Css NA 16.41 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047896 Css NA 2.732 mg/L PBTK NA 50% Rat Human -DTXSID8047896 Css NA 11.31 mg/L PBTK NA 95% Rat Human +DTXSID8047894 TK.Half.Life NA 2.111 hours 1compartment NA NA Rat Human +DTXSID8047894 Css NA 0.1283 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047894 Css NA 0.9879 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047894 Css NA 0.07503 mg/L PBTK NA 50% Rat Human +DTXSID8047894 Css NA 0.5601 mg/L PBTK NA 95% Rat Human +DTXSID8047896 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047896 Fup 0.0195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047896 Vd NA 3.105 L/kg 1compartment NA NA Human Human +DTXSID8047896 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID8047896 TK.Half.Life NA 85.27 hours 1compartment NA NA Human Human +DTXSID8047896 Css NA 3.259 mg/L 3compartmentss NA 50% Human Human +DTXSID8047896 Css NA 20.81 mg/L 3compartmentss NA 95% Human Human +DTXSID8047896 Css NA 2.251 mg/L PBTK NA 50% Human Human +DTXSID8047896 Css NA 13.95 mg/L PBTK NA 95% Human Human +DTXSID8047896 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047896 Fup 0.0195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047896 Vd NA 2.326 L/kg 1compartment NA NA Rat Human +DTXSID8047896 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID8047896 TK.Half.Life NA 11.73 hours 1compartment NA NA Rat Human +DTXSID8047896 Css NA 0.4232 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047896 Css NA 2.241 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047896 Css NA 0.2899 mg/L PBTK NA 50% Rat Human +DTXSID8047896 Css NA 1.498 mg/L PBTK NA 95% Rat Human DTXSID8047898 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8047898 Fup NA 0.518 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047898 Vd NA 0.5448 L/kg 1compartment NA NA Human Human +DTXSID8047898 Vd NA 0.537 L/kg 1compartment NA NA Human Human DTXSID8047898 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047898 TK.Half.Life NA 6.809 hours 1compartment NA NA Human Human -DTXSID8047898 Css NA 1.442 mg/L 3compartmentss NA 50% Human Human -DTXSID8047898 Css NA 7.712 mg/L 3compartmentss NA 95% Human Human -DTXSID8047898 Css NA 1.086 mg/L PBTK NA 50% Human Human -DTXSID8047898 Css NA 4.87 mg/L PBTK NA 95% Human Human +DTXSID8047898 TK.Half.Life NA 6.71 hours 1compartment NA NA Human Human +DTXSID8047898 Css NA 1.232 mg/L 3compartmentss NA 50% Human Human +DTXSID8047898 Css NA 6.617 mg/L 3compartmentss NA 95% Human Human +DTXSID8047898 Css NA 0.924 mg/L PBTK NA 50% Human Human +DTXSID8047898 Css NA 4.164 mg/L PBTK NA 95% Human Human DTXSID8047898 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8047898 Fup NA 0.518 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047898 Vd NA 0.5665 L/kg 1compartment NA NA Rat Human +DTXSID8047898 Vd NA 0.5599 L/kg 1compartment NA NA Rat Human DTXSID8047898 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047898 TK.Half.Life NA 2.412 hours 1compartment NA NA Rat Human -DTXSID8047898 Css NA 0.387 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047898 Css NA 1.879 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047898 Css NA 0.279 mg/L PBTK NA 50% Rat Human -DTXSID8047898 Css NA 1.101 mg/L PBTK NA 95% Rat Human -DTXSID8047923 Clint NA 196.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047923 Fup NA 0.1852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047923 Vd NA 3.138 L/kg 1compartment NA NA Human Human -DTXSID8047923 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047923 TK.Half.Life NA 9.723 hours 1compartment NA NA Human Human -DTXSID8047923 Css NA 0.2824 mg/L 3compartmentss NA 50% Human Human -DTXSID8047923 Css NA 1.774 mg/L 3compartmentss NA 95% Human Human -DTXSID8047923 Css NA 0.1968 mg/L PBTK NA 50% Human Human -DTXSID8047923 Css NA 1.212 mg/L PBTK NA 95% Human Human -DTXSID8047923 Clint NA 196.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047923 Fup NA 0.1852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047923 Vd NA 2.355 L/kg 1compartment NA NA Rat Human -DTXSID8047923 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047923 TK.Half.Life NA 1.755 hours 1compartment NA NA Rat Human -DTXSID8047923 Css NA 0.1574 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047923 Css NA 0.8269 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047923 Css NA 0.1052 mg/L PBTK NA 50% Rat Human -DTXSID8047923 Css NA 0.5288 mg/L PBTK NA 95% Rat Human +DTXSID8047898 TK.Half.Life NA 2.384 hours 1compartment NA NA Rat Human +DTXSID8047898 Css NA 0.02258 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047898 Css NA 0.1686 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047898 Css NA 0.01658 mg/L PBTK NA 50% Rat Human +DTXSID8047898 Css NA 0.1066 mg/L PBTK NA 95% Rat Human DTXSID8047927 Clint NA 0.2547 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8047927 Fup NA 0.7225 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047927 Vd NA 1.62 L/kg 1compartment NA NA Human Human +DTXSID8047927 Vd NA 1.035 L/kg 1compartment NA NA Human Human DTXSID8047927 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047927 TK.Half.Life NA 10.26 hours 1compartment NA NA Human Human -DTXSID8047927 Css NA 0.6095 mg/L 3compartmentss NA 50% Human Human -DTXSID8047927 Css NA 4.372 mg/L 3compartmentss NA 95% Human Human -DTXSID8047927 Css NA 0.5933 mg/L PBTK NA 50% Human Human -DTXSID8047927 Css NA 2.994 mg/L PBTK NA 95% Human Human +DTXSID8047927 TK.Half.Life NA 6.57 hours 1compartment NA NA Human Human +DTXSID8047927 Css NA 0.5868 mg/L 3compartmentss NA 50% Human Human +DTXSID8047927 Css NA 3.81 mg/L 3compartmentss NA 95% Human Human +DTXSID8047927 Css NA 0.5088 mg/L PBTK NA 50% Human Human +DTXSID8047927 Css NA 2.494 mg/L PBTK NA 95% Human Human DTXSID8047927 Clint NA 0.2547 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8047927 Fup NA 0.7225 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047927 Vd NA 1.605 L/kg 1compartment NA NA Rat Human +DTXSID8047927 Vd NA 1.04 L/kg 1compartment NA NA Rat Human DTXSID8047927 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047927 TK.Half.Life NA 4.073 hours 1compartment NA NA Rat Human -DTXSID8047927 Css NA 0.1876 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047927 Css NA 1.377 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047927 Css NA 0.1788 mg/L PBTK NA 50% Rat Human -DTXSID8047927 Css NA 0.8604 mg/L PBTK NA 95% Rat Human -DTXSID8047973 Clint NA 90.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047973 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8047973 Vd NA 1.992 L/kg 1compartment NA NA Human Human -DTXSID8047973 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8047973 TK.Half.Life NA 7.147 hours 1compartment NA NA Human Human -DTXSID8047973 Css NA 0.4532 mg/L 3compartmentss NA 50% Human Human -DTXSID8047973 Css NA 3.862 mg/L 3compartmentss NA 95% Human Human -DTXSID8047973 Css NA 0.2884 mg/L PBTK NA 50% Human Human -DTXSID8047973 Css NA 2.336 mg/L PBTK NA 95% Human Human -DTXSID8047973 Clint NA 90.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047973 Fup NA 0.0154 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8047973 Vd NA 1.479 L/kg 1compartment NA NA Rat Human -DTXSID8047973 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8047973 TK.Half.Life NA 2.327 hours 1compartment NA NA Rat Human -DTXSID8047973 Css NA 0.2562 mg/L 3compartmentss NA 50% Rat Human -DTXSID8047973 Css NA 1.842 mg/L 3compartmentss NA 95% Rat Human -DTXSID8047973 Css NA 0.1545 mg/L PBTK NA 50% Rat Human -DTXSID8047973 Css NA 1.057 mg/L PBTK NA 95% Rat Human +DTXSID8047927 TK.Half.Life NA 2.643 hours 1compartment NA NA Rat Human +DTXSID8047927 Css NA 0.01332 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047927 Css NA 0.1114 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047927 Css NA 0.01121 mg/L PBTK NA 50% Rat Human +DTXSID8047927 Css NA 0.072 mg/L PBTK NA 95% Rat Human +DTXSID8047929 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047929 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047929 Vd NA 1.098 L/kg 1compartment NA NA Human Human +DTXSID8047929 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8047929 TK.Half.Life NA 1.241 hours 1compartment NA NA Human Human +DTXSID8047929 Css NA 0.051 mg/L 3compartmentss NA 50% Human Human +DTXSID8047929 Css NA 0.4119 mg/L 3compartmentss NA 95% Human Human +DTXSID8047929 Css NA 0.04003 mg/L PBTK NA 50% Human Human +DTXSID8047929 Css NA 0.2864 mg/L PBTK NA 95% Human Human +DTXSID8047929 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047929 Fup 0.363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047929 Vd NA 1.088 L/kg 1compartment NA NA Rat Human +DTXSID8047929 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8047929 TK.Half.Life NA 0.6454 hours 1compartment NA NA Rat Human +DTXSID8047929 Css NA 0.006259 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047929 Css NA 0.03814 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047929 Css NA 0.004952 mg/L PBTK NA 50% Rat Human +DTXSID8047929 Css NA 0.02652 mg/L PBTK NA 95% Rat Human +DTXSID8047973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047973 Fup 0.00769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8047973 Vd NA 2.35 L/kg 1compartment NA NA Human Human +DTXSID8047973 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8047973 TK.Half.Life NA 44.95 hours 1compartment NA NA Human Human +DTXSID8047973 Css NA 2.8 mg/L 3compartmentss NA 50% Human Human +DTXSID8047973 Css NA 21.98 mg/L 3compartmentss NA 95% Human Human +DTXSID8047973 Css NA 1.822 mg/L PBTK NA 50% Human Human +DTXSID8047973 Css NA 13.72 mg/L PBTK NA 95% Human Human +DTXSID8047973 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047973 Fup 0.00769 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8047973 Vd NA 1.746 L/kg 1compartment NA NA Rat Human +DTXSID8047973 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8047973 TK.Half.Life NA 12.04 hours 1compartment NA NA Rat Human +DTXSID8047973 Css NA 0.3676 mg/L 3compartmentss NA 50% Rat Human +DTXSID8047973 Css NA 2.485 mg/L 3compartmentss NA 95% Rat Human +DTXSID8047973 Css NA 0.2347 mg/L PBTK NA 50% Rat Human +DTXSID8047973 Css NA 1.534 mg/L PBTK NA 95% Rat Human +DTXSID8048234 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048234 Fup 0.0327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048234 Vd NA 3.122 L/kg 1compartment NA NA Human Human +DTXSID8048234 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8048234 TK.Half.Life NA 36.44 hours 1compartment NA NA Human Human +DTXSID8048234 Css NA 1.175 mg/L 3compartmentss NA 50% Human Human +DTXSID8048234 Css NA 8.391 mg/L 3compartmentss NA 95% Human Human +DTXSID8048234 Css NA 0.8198 mg/L PBTK NA 50% Human Human +DTXSID8048234 Css NA 5.704 mg/L PBTK NA 95% Human Human +DTXSID8048234 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048234 Fup 0.0327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048234 Vd NA 2.353 L/kg 1compartment NA NA Rat Human +DTXSID8048234 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8048234 TK.Half.Life NA 5.506 hours 1compartment NA NA Rat Human +DTXSID8048234 Css NA 0.05904 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048234 Css NA 0.4106 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048234 Css NA 0.04008 mg/L PBTK NA 50% Rat Human +DTXSID8048234 Css NA 0.2673 mg/L PBTK NA 95% Rat Human +DTXSID8048238 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048238 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8048238 Vd NA 0.3681 L/kg 1compartment NA NA Human Human +DTXSID8048238 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048238 TK.Half.Life NA 3.97 hours 1compartment NA NA Human Human +DTXSID8048238 Css NA 0.7582 mg/L 3compartmentss NA 50% Human Human +DTXSID8048238 Css NA 4.951 mg/L 3compartmentss NA 95% Human Human +DTXSID8048238 Css NA 0.5338 mg/L PBTK NA 50% Human Human +DTXSID8048238 Css NA 3.019 mg/L PBTK NA 95% Human Human +DTXSID8048238 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048238 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8048238 Vd NA 0.3877 L/kg 1compartment NA NA Rat Human +DTXSID8048238 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048238 TK.Half.Life NA 1.425 hours 1compartment NA NA Rat Human +DTXSID8048238 Css NA 0.004013 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048238 Css NA 0.02767 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048238 Css NA 0.002702 mg/L PBTK NA 50% Rat Human +DTXSID8048238 Css NA 0.01586 mg/L PBTK NA 95% Rat Human +DTXSID8048280 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID8048280 Fup 0.024 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8048280 Vd NA 2.242 L/kg 1compartment NA NA Human Human +DTXSID8048280 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID8048280 TK.Half.Life NA 49.65 hours 1compartment NA NA Human Human +DTXSID8048280 Css NA 3.31 mg/L 3compartmentss NA 50% Human Human +DTXSID8048280 Css NA 23.9 mg/L 3compartmentss NA 95% Human Human +DTXSID8048280 Css NA 2.169 mg/L PBTK NA 50% Human Human +DTXSID8048280 Css NA 14.99 mg/L PBTK NA 95% Human Human +DTXSID8048280 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID8048280 Fup 0.024 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8048280 Vd NA 1.672 L/kg 1compartment NA NA Rat Human +DTXSID8048280 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8048280 TK.Half.Life NA 13.94 hours 1compartment NA NA Rat Human +DTXSID8048280 Css NA 0.4161 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048280 Css NA 2.418 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048280 Css NA 0.2672 mg/L PBTK NA 50% Rat Human +DTXSID8048280 Css NA 1.457 mg/L PBTK NA 95% Rat Human +DTXSID8048282 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048282 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8048282 Vd NA 0.225 L/kg 1compartment NA NA Human Human +DTXSID8048282 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048282 TK.Half.Life NA 1.203 hours 1compartment NA NA Human Human +DTXSID8048282 Css NA 0.4039 mg/L 3compartmentss NA 50% Human Human +DTXSID8048282 Css NA 3.112 mg/L 3compartmentss NA 95% Human Human +DTXSID8048282 Css NA 0.2452 mg/L PBTK NA 50% Human Human +DTXSID8048282 Css NA 1.803 mg/L PBTK NA 95% Human Human +DTXSID8048282 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048282 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8048282 Vd NA 0.228 L/kg 1compartment NA NA Rat Human +DTXSID8048282 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048282 TK.Half.Life NA 0.7368 hours 1compartment NA NA Rat Human +DTXSID8048282 Css NA 0.004134 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048282 Css NA 0.02552 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048282 Css NA 0.002362 mg/L PBTK NA 50% Rat Human +DTXSID8048282 Css NA 0.01416 mg/L PBTK NA 95% Rat Human +DTXSID8048286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048286 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8048286 Vd NA 5.853 L/kg 1compartment NA NA Human Human +DTXSID8048286 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048286 TK.Half.Life NA 5.934 hours 1compartment NA NA Human Human +DTXSID8048286 Css NA 0.02108 mg/L 3compartmentss NA 50% Human Human +DTXSID8048286 Css NA 0.1806 mg/L 3compartmentss NA 95% Human Human +DTXSID8048286 Css NA 0.01348 mg/L PBTK NA 50% Human Human +DTXSID8048286 Css NA 0.1155 mg/L PBTK NA 95% Human Human +DTXSID8048286 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048286 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8048286 Vd NA 5.049 L/kg 1compartment NA NA Rat Human +DTXSID8048286 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048286 TK.Half.Life NA 2.25 hours 1compartment NA NA Rat Human +DTXSID8048286 Css NA 0.002688 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048286 Css NA 0.0186 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048286 Css NA 0.001787 mg/L PBTK NA 50% Rat Human +DTXSID8048286 Css NA 0.01233 mg/L PBTK NA 95% Rat Human +DTXSID8048317 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048317 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048317 Vd NA 2.688 L/kg 1compartment NA NA Human Human +DTXSID8048317 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048317 TK.Half.Life NA 5.914 hours 1compartment NA NA Human Human +DTXSID8048317 Css NA 0.1742 mg/L 3compartmentss NA 50% Human Human +DTXSID8048317 Css NA 1.3 mg/L 3compartmentss NA 95% Human Human +DTXSID8048317 Css NA 0.1371 mg/L PBTK NA 50% Human Human +DTXSID8048317 Css NA 0.9238 mg/L PBTK NA 95% Human Human +DTXSID8048317 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048317 Fup 0.154 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048317 Vd NA 2.277 L/kg 1compartment NA NA Rat Human +DTXSID8048317 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048317 TK.Half.Life NA 2.212 hours 1compartment NA NA Rat Human +DTXSID8048317 Css NA 0.01794 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048317 Css NA 0.106 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048317 Css NA 0.01427 mg/L PBTK NA 50% Rat Human +DTXSID8048317 Css NA 0.07718 mg/L PBTK NA 95% Rat Human +DTXSID8048446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048446 Fup 0.36 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8048446 Vd NA 3.068 L/kg 1compartment NA NA Human Human +DTXSID8048446 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048446 TK.Half.Life NA 2.757 hours 1compartment NA NA Human Human +DTXSID8048446 Css NA 0.03334 mg/L 3compartmentss NA 50% Human Human +DTXSID8048446 Css NA 0.3088 mg/L 3compartmentss NA 95% Human Human +DTXSID8048446 Css NA 0.03765 mg/L PBTK NA 50% Human Human +DTXSID8048446 Css NA 0.2693 mg/L PBTK NA 95% Human Human +DTXSID8048446 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048446 Fup 0.36 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8048446 Vd NA 3.108 L/kg 1compartment NA NA Rat Human +DTXSID8048446 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048446 TK.Half.Life NA 1.529 hours 1compartment NA NA Rat Human +DTXSID8048446 Css NA 0.004065 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048446 Css NA 0.02911 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048446 Css NA 0.004741 mg/L PBTK NA 50% Rat Human +DTXSID8048446 Css NA 0.02556 mg/L PBTK NA 95% Rat Human +DTXSID8048490 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048490 Fup 0.88 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8048490 Vd NA 0.6431 L/kg 1compartment NA NA Human Human +DTXSID8048490 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048490 TK.Half.Life NA 4.728 hours 1compartment NA NA Human Human +DTXSID8048490 Css NA 0.8238 mg/L 3compartmentss NA 50% Human Human +DTXSID8048490 Css NA 4.481 mg/L 3compartmentss NA 95% Human Human +DTXSID8048490 Css NA 0.6619 mg/L PBTK NA 50% Human Human +DTXSID8048490 Css NA 2.875 mg/L PBTK NA 95% Human Human +DTXSID8048490 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048490 Fup 0.88 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8048490 Vd NA 0.6902 L/kg 1compartment NA NA Rat Human +DTXSID8048490 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048490 TK.Half.Life NA 1.729 hours 1compartment NA NA Rat Human +DTXSID8048490 Css NA 0.01514 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048490 Css NA 0.1092 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048490 Css NA 0.01165 mg/L PBTK NA 50% Rat Human +DTXSID8048490 Css NA 0.06988 mg/L PBTK NA 95% Rat Human +DTXSID8048492 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048492 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8048492 Vd NA 0.2752 L/kg 1compartment NA NA Human Human +DTXSID8048492 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048492 TK.Half.Life NA 1.514 hours 1compartment NA NA Human Human +DTXSID8048492 Css NA 0.6752 mg/L 3compartmentss NA 50% Human Human +DTXSID8048492 Css NA 4.68 mg/L 3compartmentss NA 95% Human Human +DTXSID8048492 Css NA 0.4149 mg/L PBTK NA 50% Human Human +DTXSID8048492 Css NA 2.789 mg/L PBTK NA 95% Human Human DTXSID8048492 Clint 12.5 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID8048492 Fup 0.064 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID8048492 Vd NA 0.7753 L/kg 1compartment NA NA Rat Rat +DTXSID8048492 Vd NA 0.2288 L/kg 1compartment NA NA Rat Rat DTXSID8048492 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8048492 TK.Half.Life NA 2.477 hours 1compartment NA NA Rat Rat -DTXSID8048492 Css NA 0.444 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8048492 Css NA 2.358 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8048492 Css NA 0.2629 mg/L PBTK NA 50% Rat Rat -DTXSID8048492 Css NA 1.353 mg/L PBTK NA 95% Rat Rat -DTXSID8048494 Clint NA 7.897 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048494 Fup NA 0.4851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048494 Vd NA 0.5899 L/kg 1compartment NA NA Human Human +DTXSID8048492 TK.Half.Life NA 0.7945 hours 1compartment NA NA Rat Rat +DTXSID8048492 Css NA 0.03417 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8048492 Css NA 0.2842 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8048492 Css NA 0.01946 mg/L PBTK NA 50% Rat Rat +DTXSID8048492 Css NA 0.1598 mg/L PBTK NA 95% Rat Rat +DTXSID8048494 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048494 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048494 Vd NA 0.6146 L/kg 1compartment NA NA Human Human DTXSID8048494 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048494 TK.Half.Life NA 0.9201 hours 1compartment NA NA Human Human -DTXSID8048494 Css NA 0.1157 mg/L 3compartmentss NA 50% Human Human -DTXSID8048494 Css NA 0.8533 mg/L 3compartmentss NA 95% Human Human -DTXSID8048494 Css NA 0.08693 mg/L PBTK NA 50% Human Human -DTXSID8048494 Css NA 0.5618 mg/L PBTK NA 95% Human Human -DTXSID8048494 Clint NA 7.897 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048494 Fup NA 0.4851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048494 Vd NA 0.5981 L/kg 1compartment NA NA Rat Human +DTXSID8048494 TK.Half.Life NA 0.892 hours 1compartment NA NA Human Human +DTXSID8048494 Css NA 0.1065 mg/L 3compartmentss NA 50% Human Human +DTXSID8048494 Css NA 0.9694 mg/L 3compartmentss NA 95% Human Human +DTXSID8048494 Css NA 0.08204 mg/L PBTK NA 50% Human Human +DTXSID8048494 Css NA 0.6298 mg/L PBTK NA 95% Human Human +DTXSID8048494 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048494 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048494 Vd NA 0.6369 L/kg 1compartment NA NA Rat Human DTXSID8048494 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048494 TK.Half.Life NA 0.5074 hours 1compartment NA NA Rat Human -DTXSID8048494 Css NA 0.05808 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048494 Css NA 0.3361 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048494 Css NA 0.04208 mg/L PBTK NA 50% Rat Human -DTXSID8048494 Css NA 0.2044 mg/L PBTK NA 95% Rat Human -DTXSID8048521 Clint NA 141.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048521 Fup NA 0.1016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048521 Vd NA 2.945 L/kg 1compartment NA NA Human Human -DTXSID8048521 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048521 TK.Half.Life NA 5.545 hours 1compartment NA NA Human Human -DTXSID8048521 Css NA 0.1398 mg/L 3compartmentss NA 50% Human Human -DTXSID8048521 Css NA 0.9079 mg/L 3compartmentss NA 95% Human Human -DTXSID8048521 Css NA 0.0979 mg/L PBTK NA 50% Human Human -DTXSID8048521 Css NA 0.6111 mg/L PBTK NA 95% Human Human -DTXSID8048521 Clint NA 141.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048521 Fup NA 0.1016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048521 Vd NA 2.222 L/kg 1compartment NA NA Rat Human -DTXSID8048521 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048521 TK.Half.Life NA 1.328 hours 1compartment NA NA Rat Human -DTXSID8048521 Css NA 0.0785 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048521 Css NA 0.4314 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048521 Css NA 0.05279 mg/L PBTK NA 50% Rat Human -DTXSID8048521 Css NA 0.2806 mg/L PBTK NA 95% Rat Human +DTXSID8048494 TK.Half.Life NA 0.498 hours 1compartment NA NA Rat Human +DTXSID8048494 Css NA 0.01209 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048494 Css NA 0.09412 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048494 Css NA 0.009455 mg/L PBTK NA 50% Rat Human +DTXSID8048494 Css NA 0.0584 mg/L PBTK NA 95% Rat Human +DTXSID8048496 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048496 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8048496 Vd NA 1.568 L/kg 1compartment NA NA Human Human +DTXSID8048496 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048496 TK.Half.Life NA 10.52 hours 1compartment NA NA Human Human +DTXSID8048496 Css NA 0.9808 mg/L 3compartmentss NA 50% Human Human +DTXSID8048496 Css NA 8.658 mg/L 3compartmentss NA 95% Human Human +DTXSID8048496 Css NA 0.6304 mg/L PBTK NA 50% Human Human +DTXSID8048496 Css NA 5.37 mg/L PBTK NA 95% Human Human +DTXSID8048496 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048496 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8048496 Vd NA 1.225 L/kg 1compartment NA NA Rat Human +DTXSID8048496 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048496 TK.Half.Life NA 4.37 hours 1compartment NA NA Rat Human +DTXSID8048496 Css NA 0.128 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048496 Css NA 0.9156 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048496 Css NA 0.07997 mg/L PBTK NA 50% Rat Human +DTXSID8048496 Css NA 0.5438 mg/L PBTK NA 95% Rat Human +DTXSID8048521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048521 Fup 0.0598 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048521 Vd NA 3.063 L/kg 1compartment NA NA Human Human +DTXSID8048521 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8048521 TK.Half.Life NA 48 hours 1compartment NA NA Human Human +DTXSID8048521 Css NA 1.003 mg/L 3compartmentss NA 50% Human Human +DTXSID8048521 Css NA 6.976 mg/L 3compartmentss NA 95% Human Human +DTXSID8048521 Css NA 0.6972 mg/L PBTK NA 50% Human Human +DTXSID8048521 Css NA 4.76 mg/L PBTK NA 95% Human Human +DTXSID8048521 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048521 Fup 0.0598 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048521 Vd NA 2.3 L/kg 1compartment NA NA Rat Human +DTXSID8048521 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8048521 TK.Half.Life NA 7.306 hours 1compartment NA NA Rat Human +DTXSID8048521 Css NA 0.01087 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048521 Css NA 0.07222 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048521 Css NA 0.007258 mg/L PBTK NA 50% Rat Human +DTXSID8048521 Css NA 0.04632 mg/L PBTK NA 95% Rat Human +DTXSID8048529 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048529 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID8048529 Vd NA 3.614 L/kg 1compartment NA NA Human Human +DTXSID8048529 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8048529 TK.Half.Life NA 26.03 hours 1compartment NA NA Human Human +DTXSID8048529 Css NA 0.4936 mg/L 3compartmentss NA 50% Human Human +DTXSID8048529 Css NA 2.348 mg/L 3compartmentss NA 95% Human Human +DTXSID8048529 Css NA 0.6334 mg/L PBTK NA 50% Human Human +DTXSID8048529 Css NA 2.086 mg/L PBTK NA 95% Human Human +DTXSID8048529 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048529 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID8048529 Vd NA 3.685 L/kg 1compartment NA NA Rat Human +DTXSID8048529 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048529 TK.Half.Life NA 9.032 hours 1compartment NA NA Rat Human +DTXSID8048529 Css NA 0.01192 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048529 Css NA 0.06985 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048529 Css NA 0.0152 mg/L PBTK NA 50% Rat Human +DTXSID8048529 Css NA 0.06576 mg/L PBTK NA 95% Rat Human DTXSID8048575 Clint NA 47.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8048575 Fup NA 0.5151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048575 Vd NA 1.791 L/kg 1compartment NA NA Human Human +DTXSID8048575 Vd NA 0.4901 L/kg 1compartment NA NA Human Human DTXSID8048575 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048575 TK.Half.Life NA 1.3 hours 1compartment NA NA Human Human -DTXSID8048575 Css NA 0.01663 mg/L 3compartmentss NA 50% Human Human -DTXSID8048575 Css NA 0.162 mg/L 3compartmentss NA 95% Human Human -DTXSID8048575 Css NA 0.01499 mg/L PBTK NA 50% Human Human -DTXSID8048575 Css NA 0.1203 mg/L PBTK NA 95% Human Human +DTXSID8048575 TK.Half.Life NA 0.4268 hours 1compartment NA NA Human Human +DTXSID8048575 Css NA 0.01311 mg/L 3compartmentss NA 50% Human Human +DTXSID8048575 Css NA 0.1535 mg/L 3compartmentss NA 95% Human Human +DTXSID8048575 Css NA 0.009497 mg/L PBTK NA 50% Human Human +DTXSID8048575 Css NA 0.09903 mg/L PBTK NA 95% Human Human DTXSID8048575 Clint NA 47.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8048575 Fup NA 0.5151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048575 Vd NA 1.789 L/kg 1compartment NA NA Rat Human +DTXSID8048575 Vd NA 0.4925 L/kg 1compartment NA NA Rat Human DTXSID8048575 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048575 TK.Half.Life NA 0.6217 hours 1compartment NA NA Rat Human -DTXSID8048575 Css NA 0.008692 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048575 Css NA 0.07205 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048575 Css NA 0.007714 mg/L PBTK NA 50% Rat Human -DTXSID8048575 Css NA 0.05136 mg/L PBTK NA 95% Rat Human -DTXSID8048577 Clint NA 22.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048577 Fup NA 0.0574 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048577 Vd NA 0.3118 L/kg 1compartment NA NA Human Human +DTXSID8048575 TK.Half.Life NA 0.2016 hours 1compartment NA NA Rat Human +DTXSID8048575 Css NA 0.0004758 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048575 Css NA 0.006284 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048575 Css NA 0.0003394 mg/L PBTK NA 50% Rat Human +DTXSID8048575 Css NA 0.004047 mg/L PBTK NA 95% Rat Human +DTXSID8048577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048577 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048577 Vd NA 0.5115 L/kg 1compartment NA NA Human Human DTXSID8048577 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048577 TK.Half.Life NA 1.202 hours 1compartment NA NA Human Human -DTXSID8048577 Css NA 0.5406 mg/L 3compartmentss NA 50% Human Human -DTXSID8048577 Css NA 4.368 mg/L 3compartmentss NA 95% Human Human -DTXSID8048577 Css NA 0.3255 mg/L PBTK NA 50% Human Human -DTXSID8048577 Css NA 2.553 mg/L PBTK NA 95% Human Human -DTXSID8048577 Clint NA 22.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048577 Fup NA 0.0574 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048577 Vd NA 0.2872 L/kg 1compartment NA NA Rat Human +DTXSID8048577 TK.Half.Life NA 0.7815 hours 1compartment NA NA Human Human +DTXSID8048577 Css NA 0.07882 mg/L 3compartmentss NA 50% Human Human +DTXSID8048577 Css NA 0.6125 mg/L 3compartmentss NA 95% Human Human +DTXSID8048577 Css NA 0.05332 mg/L PBTK NA 50% Human Human +DTXSID8048577 Css NA 0.3916 mg/L PBTK NA 95% Human Human +DTXSID8048577 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048577 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048577 Vd NA 0.4878 L/kg 1compartment NA NA Rat Human DTXSID8048577 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048577 TK.Half.Life NA 0.6856 hours 1compartment NA NA Rat Human -DTXSID8048577 Css NA 0.3064 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048577 Css NA 1.878 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048577 Css NA 0.1729 mg/L PBTK NA 50% Rat Human -DTXSID8048577 Css NA 1.038 mg/L PBTK NA 95% Rat Human -DTXSID8048579 Clint NA 230.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8048577 TK.Half.Life NA 0.4053 hours 1compartment NA NA Rat Human +DTXSID8048577 Css NA 0.003746 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048577 Css NA 0.03159 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048577 Css NA 0.002492 mg/L PBTK NA 50% Rat Human +DTXSID8048577 Css NA 0.01951 mg/L PBTK NA 95% Rat Human +DTXSID8048579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8048579 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8048579 Vd NA 0.2552 L/kg 1compartment NA NA Human Human -DTXSID8048579 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048579 TK.Half.Life NA 0.3002 hours 1compartment NA NA Human Human -DTXSID8048579 Css NA 0.0439 mg/L 3compartmentss NA 50% Human Human -DTXSID8048579 Css NA 0.3584 mg/L 3compartmentss NA 95% Human Human -DTXSID8048579 Css NA 0.02642 mg/L PBTK NA 50% Human Human -DTXSID8048579 Css NA 0.2103 mg/L PBTK NA 95% Human Human -DTXSID8048579 Clint NA 230.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8048579 Vd NA 0.2444 L/kg 1compartment NA NA Human Human +DTXSID8048579 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8048579 TK.Half.Life NA 22.6 hours 1compartment NA NA Human Human +DTXSID8048579 Css NA 12.95 mg/L 3compartmentss NA 50% Human Human +DTXSID8048579 Css NA 57.33 mg/L 3compartmentss NA 95% Human Human +DTXSID8048579 Css NA 7.808 mg/L PBTK NA 50% Human Human +DTXSID8048579 Css NA 33.11 mg/L PBTK NA 95% Human Human +DTXSID8048579 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8048579 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8048579 Vd NA 0.2491 L/kg 1compartment NA NA Rat Human +DTXSID8048579 Vd NA 0.2413 L/kg 1compartment NA NA Rat Human DTXSID8048579 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048579 TK.Half.Life NA 0.1434 hours 1compartment NA NA Rat Human -DTXSID8048579 Css NA 0.02522 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048579 Css NA 0.1668 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048579 Css NA 0.01419 mg/L PBTK NA 50% Rat Human -DTXSID8048579 Css NA 0.09217 mg/L PBTK NA 95% Rat Human -DTXSID8048600 Clint NA 82.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048600 Fup NA 0.0209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048600 Vd NA 2.292 L/kg 1compartment NA NA Human Human -DTXSID8048600 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048600 TK.Half.Life NA 8.138 hours 1compartment NA NA Human Human -DTXSID8048600 Css NA 0.4324 mg/L 3compartmentss NA 50% Human Human -DTXSID8048600 Css NA 3.541 mg/L 3compartmentss NA 95% Human Human -DTXSID8048600 Css NA 0.2817 mg/L PBTK NA 50% Human Human -DTXSID8048600 Css NA 2.189 mg/L PBTK NA 95% Human Human -DTXSID8048600 Clint NA 82.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048600 Fup NA 0.0209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048600 Vd NA 1.708 L/kg 1compartment NA NA Rat Human -DTXSID8048600 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048600 TK.Half.Life NA 2.362 hours 1compartment NA NA Rat Human -DTXSID8048600 Css NA 0.2446 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048600 Css NA 1.554 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048600 Css NA 0.151 mg/L PBTK NA 50% Rat Human -DTXSID8048600 Css NA 0.9204 mg/L PBTK NA 95% Rat Human -DTXSID8048602 Clint NA 64.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048602 Fup NA 0.1881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048602 Vd NA 1.635 L/kg 1compartment NA NA Human Human +DTXSID8048579 TK.Half.Life NA 7.603 hours 1compartment NA NA Rat Human +DTXSID8048579 Css NA 0.3146 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048579 Css NA 1.832 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048579 Css NA 0.1813 mg/L PBTK NA 50% Rat Human +DTXSID8048579 Css NA 1.037 mg/L PBTK NA 95% Rat Human +DTXSID8048600 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048600 Fup 0.0216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048600 Vd NA 2.575 L/kg 1compartment NA NA Human Human +DTXSID8048600 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8048600 TK.Half.Life NA 32.12 hours 1compartment NA NA Human Human +DTXSID8048600 Css NA 1.697 mg/L 3compartmentss NA 50% Human Human +DTXSID8048600 Css NA 12.72 mg/L 3compartmentss NA 95% Human Human +DTXSID8048600 Css NA 1.134 mg/L PBTK NA 50% Human Human +DTXSID8048600 Css NA 8.113 mg/L PBTK NA 95% Human Human +DTXSID8048600 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048600 Fup 0.0216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048600 Vd NA 1.923 L/kg 1compartment NA NA Rat Human +DTXSID8048600 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8048600 TK.Half.Life NA 7.552 hours 1compartment NA NA Rat Human +DTXSID8048600 Css NA 0.2196 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048600 Css NA 1.336 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048600 Css NA 0.1433 mg/L PBTK NA 50% Rat Human +DTXSID8048600 Css NA 0.8582 mg/L PBTK NA 95% Rat Human +DTXSID8048602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048602 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048602 Vd NA 1.735 L/kg 1compartment NA NA Human Human DTXSID8048602 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048602 TK.Half.Life NA 1.73 hours 1compartment NA NA Human Human -DTXSID8048602 Css NA 0.03966 mg/L 3compartmentss NA 50% Human Human -DTXSID8048602 Css NA 0.3012 mg/L 3compartmentss NA 95% Human Human -DTXSID8048602 Css NA 0.03024 mg/L PBTK NA 50% Human Human -DTXSID8048602 Css NA 0.2091 mg/L PBTK NA 95% Human Human -DTXSID8048602 Clint NA 64.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048602 Fup NA 0.1881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048602 Vd NA 1.444 L/kg 1compartment NA NA Rat Human +DTXSID8048602 TK.Half.Life NA 5.196 hours 1compartment NA NA Human Human +DTXSID8048602 Css NA 0.2188 mg/L 3compartmentss NA 50% Human Human +DTXSID8048602 Css NA 1.449 mg/L 3compartmentss NA 95% Human Human +DTXSID8048602 Css NA 0.1759 mg/L PBTK NA 50% Human Human +DTXSID8048602 Css NA 1.026 mg/L PBTK NA 95% Human Human +DTXSID8048602 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048602 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048602 Vd NA 1.569 L/kg 1compartment NA NA Rat Human DTXSID8048602 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048602 TK.Half.Life NA 0.7475 hours 1compartment NA NA Rat Human -DTXSID8048602 Css NA 0.02212 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048602 Css NA 0.1279 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048602 Css NA 0.01616 mg/L PBTK NA 50% Rat Human -DTXSID8048602 Css NA 0.08756 mg/L PBTK NA 95% Rat Human -DTXSID8048604 Clint NA 2512 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048604 Fup NA 0.2126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048604 Vd NA 2.192 L/kg 1compartment NA NA Human Human -DTXSID8048604 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048604 TK.Half.Life NA 1.494 hours 1compartment NA NA Human Human -DTXSID8048604 Css NA 0.0009418 mg/L 3compartmentss NA 50% Human Human -DTXSID8048604 Css NA 0.00708 mg/L 3compartmentss NA 95% Human Human -DTXSID8048604 Css NA 0.000766 mg/L PBTK NA 50% Human Human -DTXSID8048604 Css NA 0.00521 mg/L PBTK NA 95% Human Human -DTXSID8048604 Clint NA 2512 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048604 Fup NA 0.2126 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048604 Vd NA 1.941 L/kg 1compartment NA NA Rat Human -DTXSID8048604 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048604 TK.Half.Life NA 0.5767 hours 1compartment NA NA Rat Human -DTXSID8048604 Css NA 0.0005153 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048604 Css NA 0.003172 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048604 Css NA 0.0004079 mg/L PBTK NA 50% Rat Human -DTXSID8048604 Css NA 0.002314 mg/L PBTK NA 95% Rat Human -DTXSID8048606 Clint NA 84.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048606 Fup NA 0.004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048606 Vd NA 0.1949 L/kg 1compartment NA NA Human Human +DTXSID8048602 TK.Half.Life NA 2.534 hours 1compartment NA NA Rat Human +DTXSID8048602 Css NA 0.009613 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048602 Css NA 0.07315 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048602 Css NA 0.007848 mg/L PBTK NA 50% Rat Human +DTXSID8048602 Css NA 0.05107 mg/L PBTK NA 95% Rat Human +DTXSID8048606 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048606 Fup 0.0232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048606 Vd NA 0.3192 L/kg 1compartment NA NA Human Human DTXSID8048606 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048606 TK.Half.Life NA 2.393 hours 1compartment NA NA Human Human -DTXSID8048606 Css NA 2.188 mg/L 3compartmentss NA 50% Human Human -DTXSID8048606 Css NA 16.86 mg/L 3compartmentss NA 95% Human Human -DTXSID8048606 Css NA 1.284 mg/L PBTK NA 50% Human Human -DTXSID8048606 Css NA 9.637 mg/L PBTK NA 95% Human Human -DTXSID8048606 Clint NA 84.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048606 Fup NA 0.004 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048606 Vd NA 0.1885 L/kg 1compartment NA NA Rat Human +DTXSID8048606 TK.Half.Life NA 2.656 hours 1compartment NA NA Human Human +DTXSID8048606 Css NA 1.36 mg/L 3compartmentss NA 50% Human Human +DTXSID8048606 Css NA 13.47 mg/L 3compartmentss NA 95% Human Human +DTXSID8048606 Css NA 0.8351 mg/L PBTK NA 50% Human Human +DTXSID8048606 Css NA 7.962 mg/L PBTK NA 95% Human Human +DTXSID8048606 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048606 Fup 0.0232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048606 Vd NA 0.3057 L/kg 1compartment NA NA Rat Human DTXSID8048606 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048606 TK.Half.Life NA 1.564 hours 1compartment NA NA Rat Human -DTXSID8048606 Css NA 1.265 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048606 Css NA 7.518 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048606 Css NA 0.69 mg/L PBTK NA 50% Rat Human -DTXSID8048606 Css NA 4.092 mg/L PBTK NA 95% Rat Human -DTXSID8048608 Clint NA 14.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048608 Fup NA 0.0227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048608 Vd NA 2.401 L/kg 1compartment NA NA Human Human -DTXSID8048608 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8048608 TK.Half.Life NA 38.32 hours 1compartment NA NA Human Human -DTXSID8048608 Css NA 2.351 mg/L 3compartmentss NA 50% Human Human -DTXSID8048608 Css NA 17.12 mg/L 3compartmentss NA 95% Human Human -DTXSID8048608 Css NA 1.555 mg/L PBTK NA 50% Human Human -DTXSID8048608 Css NA 10.7 mg/L PBTK NA 95% Human Human -DTXSID8048608 Clint NA 14.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048608 Fup NA 0.0227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048608 Vd NA 1.791 L/kg 1compartment NA NA Rat Human -DTXSID8048608 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8048608 TK.Half.Life NA 9.972 hours 1compartment NA NA Rat Human -DTXSID8048608 Css NA 1.294 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048608 Css NA 7.551 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048608 Css NA 0.8069 mg/L PBTK NA 50% Rat Human -DTXSID8048608 Css NA 4.56 mg/L PBTK NA 95% Rat Human -DTXSID8048650 Clint NA 6.549 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048650 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048650 Vd NA 0.2181 L/kg 1compartment NA NA Human Human +DTXSID8048606 TK.Half.Life NA 1.662 hours 1compartment NA NA Rat Human +DTXSID8048606 Css NA 0.1751 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048606 Css NA 1.454 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048606 Css NA 0.103 mg/L PBTK NA 50% Rat Human +DTXSID8048606 Css NA 0.8263 mg/L PBTK NA 95% Rat Human +DTXSID8048650 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048650 Fup 0.0802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048650 Vd NA 0.3829 L/kg 1compartment NA NA Human Human DTXSID8048650 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048650 TK.Half.Life NA 7.396 hours 1compartment NA NA Human Human -DTXSID8048650 Css NA 6.285 mg/L 3compartmentss NA 50% Human Human -DTXSID8048650 Css NA 53.12 mg/L 3compartmentss NA 95% Human Human -DTXSID8048650 Css NA 3.74 mg/L PBTK NA 50% Human Human -DTXSID8048650 Css NA 31.03 mg/L PBTK NA 95% Human Human -DTXSID8048650 Clint NA 6.549 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048650 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048650 Vd NA 0.2129 L/kg 1compartment NA NA Rat Human +DTXSID8048650 TK.Half.Life NA 3.001 hours 1compartment NA NA Human Human +DTXSID8048650 Css NA 1.156 mg/L 3compartmentss NA 50% Human Human +DTXSID8048650 Css NA 7.822 mg/L 3compartmentss NA 95% Human Human +DTXSID8048650 Css NA 0.7393 mg/L PBTK NA 50% Human Human +DTXSID8048650 Css NA 4.779 mg/L PBTK NA 95% Human Human +DTXSID8048650 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048650 Fup 0.0802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048650 Vd NA 0.3749 L/kg 1compartment NA NA Rat Human DTXSID8048650 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048650 TK.Half.Life NA 4.606 hours 1compartment NA NA Rat Human -DTXSID8048650 Css NA 3.332 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048650 Css NA 22.16 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048650 Css NA 1.84 mg/L PBTK NA 50% Rat Human -DTXSID8048650 Css NA 12.03 mg/L PBTK NA 95% Rat Human -DTXSID8048652 Clint NA 1.681 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048652 Fup NA 0.2229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048652 Vd NA 3.139 L/kg 1compartment NA NA Human Human -DTXSID8048652 Days.Css NA 192 Days PBTK NA NA Human Human -DTXSID8048652 TK.Half.Life NA 775.4 hours 1compartment NA NA Human Human -DTXSID8048652 Css NA 30.26 mg/L 3compartmentss NA 50% Human Human -DTXSID8048652 Css NA 165.4 mg/L 3compartmentss NA 95% Human Human -DTXSID8048652 Css NA 21.16 mg/L PBTK NA 50% Human Human -DTXSID8048652 Css NA 112 mg/L PBTK NA 95% Human Human -DTXSID8048652 Clint NA 1.681 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048652 Fup NA 0.2229 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048652 Vd NA 2.357 L/kg 1compartment NA NA Rat Human -DTXSID8048652 Days.Css NA 98 Days PBTK NA NA Rat Human -DTXSID8048652 TK.Half.Life NA 95.21 hours 1compartment NA NA Rat Human -DTXSID8048652 Css NA 16.06 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048652 Css NA 66.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048652 Css NA 10.76 mg/L PBTK NA 50% Rat Human -DTXSID8048652 Css NA 43.97 mg/L PBTK NA 95% Rat Human -DTXSID8048654 Clint NA 168.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048654 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048654 Vd NA 2.265 L/kg 1compartment NA NA Human Human -DTXSID8048654 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048654 TK.Half.Life NA 4.912 hours 1compartment NA NA Human Human -DTXSID8048654 Css NA 0.212 mg/L 3compartmentss NA 50% Human Human -DTXSID8048654 Css NA 1.716 mg/L 3compartmentss NA 95% Human Human -DTXSID8048654 Css NA 0.1392 mg/L PBTK NA 50% Human Human -DTXSID8048654 Css NA 1.074 mg/L PBTK NA 95% Human Human -DTXSID8048654 Clint NA 168.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048654 Fup NA 0.0193 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048654 Vd NA 1.722 L/kg 1compartment NA NA Rat Human -DTXSID8048654 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048654 TK.Half.Life NA 1.557 hours 1compartment NA NA Rat Human -DTXSID8048654 Css NA 0.118 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048654 Css NA 0.8189 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048654 Css NA 0.07394 mg/L PBTK NA 50% Rat Human -DTXSID8048654 Css NA 0.4852 mg/L PBTK NA 95% Rat Human -DTXSID8048656 Clint NA 235.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048656 Fup NA 0.0338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048656 Vd NA 2.681 L/kg 1compartment NA NA Human Human +DTXSID8048650 TK.Half.Life NA 1.811 hours 1compartment NA NA Rat Human +DTXSID8048650 Css NA 0.1421 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048650 Css NA 0.7167 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048650 Css NA 0.088 mg/L PBTK NA 50% Rat Human +DTXSID8048650 Css NA 0.4207 mg/L PBTK NA 95% Rat Human +DTXSID8048652 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048652 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048652 Vd NA 0.3936 L/kg 1compartment NA NA Human Human +DTXSID8048652 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048652 TK.Half.Life NA 1.32 hours 1compartment NA NA Human Human +DTXSID8048652 Css NA 0.3352 mg/L 3compartmentss NA 50% Human Human +DTXSID8048652 Css NA 1.94 mg/L 3compartmentss NA 95% Human Human +DTXSID8048652 Css NA 0.2206 mg/L PBTK NA 50% Human Human +DTXSID8048652 Css NA 1.214 mg/L PBTK NA 95% Human Human +DTXSID8048652 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048652 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048652 Vd NA 0.3753 L/kg 1compartment NA NA Rat Human +DTXSID8048652 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048652 TK.Half.Life NA 0.733 hours 1compartment NA NA Rat Human +DTXSID8048652 Css NA 0.04007 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048652 Css NA 0.1733 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048652 Css NA 0.02582 mg/L PBTK NA 50% Rat Human +DTXSID8048652 Css NA 0.1034 mg/L PBTK NA 95% Rat Human +DTXSID8048654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048654 Fup 0.0633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048654 Vd NA 2.857 L/kg 1compartment NA NA Human Human +DTXSID8048654 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8048654 TK.Half.Life NA 21.14 hours 1compartment NA NA Human Human +DTXSID8048654 Css NA 0.8626 mg/L 3compartmentss NA 50% Human Human +DTXSID8048654 Css NA 5.808 mg/L 3compartmentss NA 95% Human Human +DTXSID8048654 Css NA 0.6071 mg/L PBTK NA 50% Human Human +DTXSID8048654 Css NA 3.888 mg/L PBTK NA 95% Human Human +DTXSID8048654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048654 Fup 0.0633 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048654 Vd NA 2.194 L/kg 1compartment NA NA Rat Human +DTXSID8048654 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8048654 TK.Half.Life NA 4.767 hours 1compartment NA NA Rat Human +DTXSID8048654 Css NA 0.1113 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048654 Css NA 0.5983 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048654 Css NA 0.07733 mg/L PBTK NA 50% Rat Human +DTXSID8048654 Css NA 0.4067 mg/L PBTK NA 95% Rat Human +DTXSID8048656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048656 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048656 Vd NA 0.5764 L/kg 1compartment NA NA Human Human DTXSID8048656 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048656 TK.Half.Life NA 4.53 hours 1compartment NA NA Human Human -DTXSID8048656 Css NA 0.124 mg/L 3compartmentss NA 50% Human Human -DTXSID8048656 Css NA 0.8648 mg/L 3compartmentss NA 95% Human Human -DTXSID8048656 Css NA 0.08414 mg/L PBTK NA 50% Human Human -DTXSID8048656 Css NA 0.566 mg/L PBTK NA 95% Human Human -DTXSID8048656 Clint NA 235.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048656 Fup NA 0.0338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048656 Vd NA 2.022 L/kg 1compartment NA NA Rat Human +DTXSID8048656 TK.Half.Life NA 0.9902 hours 1compartment NA NA Human Human +DTXSID8048656 Css NA 0.1161 mg/L 3compartmentss NA 50% Human Human +DTXSID8048656 Css NA 0.8253 mg/L 3compartmentss NA 95% Human Human +DTXSID8048656 Css NA 0.07794 mg/L PBTK NA 50% Human Human +DTXSID8048656 Css NA 0.5293 mg/L PBTK NA 95% Human Human +DTXSID8048656 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048656 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048656 Vd NA 0.5663 L/kg 1compartment NA NA Rat Human DTXSID8048656 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048656 TK.Half.Life NA 1.25 hours 1compartment NA NA Rat Human -DTXSID8048656 Css NA 0.0711 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048656 Css NA 0.4033 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048656 Css NA 0.0458 mg/L PBTK NA 50% Rat Human -DTXSID8048656 Css NA 0.2483 mg/L PBTK NA 95% Rat Human -DTXSID8048658 Clint NA 22.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048658 Fup NA 0.0218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048658 Vd NA 0.2445 L/kg 1compartment NA NA Human Human +DTXSID8048656 TK.Half.Life NA 0.5432 hours 1compartment NA NA Rat Human +DTXSID8048656 Css NA 0.01476 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048656 Css NA 0.08014 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048656 Css NA 0.009766 mg/L PBTK NA 50% Rat Human +DTXSID8048656 Css NA 0.05033 mg/L PBTK NA 95% Rat Human +DTXSID8048658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048658 Fup 0.031 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048658 Vd NA 0.2743 L/kg 1compartment NA NA Human Human DTXSID8048658 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048658 TK.Half.Life NA 2.128 hours 1compartment NA NA Human Human -DTXSID8048658 Css NA 1.523 mg/L 3compartmentss NA 50% Human Human -DTXSID8048658 Css NA 14.18 mg/L 3compartmentss NA 95% Human Human -DTXSID8048658 Css NA 0.9072 mg/L PBTK NA 50% Human Human -DTXSID8048658 Css NA 8.27 mg/L PBTK NA 95% Human Human -DTXSID8048658 Clint NA 22.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048658 Fup NA 0.0218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048658 Vd NA 0.2332 L/kg 1compartment NA NA Rat Human +DTXSID8048658 TK.Half.Life NA 1.777 hours 1compartment NA NA Human Human +DTXSID8048658 Css NA 1.019 mg/L 3compartmentss NA 50% Human Human +DTXSID8048658 Css NA 9.799 mg/L 3compartmentss NA 95% Human Human +DTXSID8048658 Css NA 0.6182 mg/L PBTK NA 50% Human Human +DTXSID8048658 Css NA 5.808 mg/L PBTK NA 95% Human Human +DTXSID8048658 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048658 Fup 0.031 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048658 Vd NA 0.2608 L/kg 1compartment NA NA Rat Human DTXSID8048658 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048658 TK.Half.Life NA 1.328 hours 1compartment NA NA Rat Human -DTXSID8048658 Css NA 0.8262 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048658 Css NA 6.495 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048658 Css NA 0.4604 mg/L PBTK NA 50% Rat Human -DTXSID8048658 Css NA 3.557 mg/L PBTK NA 95% Rat Human -DTXSID8048731 Clint NA 35.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048731 Fup NA 0.1976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048731 Vd NA 3.136 L/kg 1compartment NA NA Human Human -DTXSID8048731 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID8048731 TK.Half.Life NA 50.52 hours 1compartment NA NA Human Human -DTXSID8048731 Css NA 1.9 mg/L 3compartmentss NA 50% Human Human -DTXSID8048731 Css NA 12.01 mg/L 3compartmentss NA 95% Human Human -DTXSID8048731 Css NA 1.326 mg/L PBTK NA 50% Human Human -DTXSID8048731 Css NA 8.052 mg/L PBTK NA 95% Human Human -DTXSID8048731 Clint NA 35.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048731 Fup NA 0.1976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048731 Vd NA 2.35 L/kg 1compartment NA NA Rat Human -DTXSID8048731 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID8048731 TK.Half.Life NA 6.89 hours 1compartment NA NA Rat Human -DTXSID8048731 Css NA 1.051 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048731 Css NA 5.524 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048731 Css NA 0.7036 mg/L PBTK NA 50% Rat Human -DTXSID8048731 Css NA 3.561 mg/L PBTK NA 95% Rat Human -DTXSID8048733 Clint NA 90.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8048658 TK.Half.Life NA 1.09 hours 1compartment NA NA Rat Human +DTXSID8048658 Css NA 0.1343 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048658 Css NA 1.045 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048658 Css NA 0.07848 mg/L PBTK NA 50% Rat Human +DTXSID8048658 Css NA 0.5945 mg/L PBTK NA 95% Rat Human +DTXSID8048731 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048731 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048731 Vd NA 3.261 L/kg 1compartment NA NA Human Human +DTXSID8048731 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID8048731 TK.Half.Life NA 98.8 hours 1compartment NA NA Human Human +DTXSID8048731 Css NA 3.412 mg/L 3compartmentss NA 50% Human Human +DTXSID8048731 Css NA 19.84 mg/L 3compartmentss NA 95% Human Human +DTXSID8048731 Css NA 2.399 mg/L PBTK NA 50% Human Human +DTXSID8048731 Css NA 13.83 mg/L PBTK NA 95% Human Human +DTXSID8048731 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048731 Fup 0.0113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048731 Vd NA 2.447 L/kg 1compartment NA NA Rat Human +DTXSID8048731 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID8048731 TK.Half.Life NA 13.4 hours 1compartment NA NA Rat Human +DTXSID8048731 Css NA 0.4443 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048731 Css NA 2.271 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048731 Css NA 0.3089 mg/L PBTK NA 50% Rat Human +DTXSID8048731 Css NA 1.583 mg/L PBTK NA 95% Rat Human +DTXSID8048733 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8048733 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8048733 Vd NA 0.4557 L/kg 1compartment NA NA Human Human -DTXSID8048733 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048733 TK.Half.Life NA 2.171 hours 1compartment NA NA Human Human -DTXSID8048733 Css NA 0.7312 mg/L 3compartmentss NA 50% Human Human -DTXSID8048733 Css NA 7.722 mg/L 3compartmentss NA 95% Human Human -DTXSID8048733 Css NA 0.4306 mg/L PBTK NA 50% Human Human -DTXSID8048733 Css NA 4.437 mg/L PBTK NA 95% Human Human -DTXSID8048733 Clint NA 90.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8048733 Vd NA 0.5462 L/kg 1compartment NA NA Human Human +DTXSID8048733 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8048733 TK.Half.Life NA 27.88 hours 1compartment NA NA Human Human +DTXSID8048733 Css NA 9.216 mg/L 3compartmentss NA 50% Human Human +DTXSID8048733 Css NA 81.14 mg/L 3compartmentss NA 95% Human Human +DTXSID8048733 Css NA 5.47 mg/L PBTK NA 50% Human Human +DTXSID8048733 Css NA 47.32 mg/L PBTK NA 95% Human Human +DTXSID8048733 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8048733 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8048733 Vd NA 0.3656 L/kg 1compartment NA NA Rat Human -DTXSID8048733 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048733 TK.Half.Life NA 1.103 hours 1compartment NA NA Rat Human -DTXSID8048733 Css NA 0.4257 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048733 Css NA 3.637 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048733 Css NA 0.235 mg/L PBTK NA 50% Rat Human -DTXSID8048733 Css NA 1.982 mg/L PBTK NA 95% Rat Human -DTXSID8048735 Clint NA 1.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048735 Fup NA 0.5796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048735 Vd NA 0.6252 L/kg 1compartment NA NA Human Human -DTXSID8048735 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048735 TK.Half.Life NA 1.887 hours 1compartment NA NA Human Human -DTXSID8048735 Css NA 0.3126 mg/L 3compartmentss NA 50% Human Human -DTXSID8048735 Css NA 2.283 mg/L 3compartmentss NA 95% Human Human -DTXSID8048735 Css NA 0.2464 mg/L PBTK NA 50% Human Human -DTXSID8048735 Css NA 1.467 mg/L PBTK NA 95% Human Human -DTXSID8048735 Clint NA 1.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048735 Fup NA 0.5796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048735 Vd NA 0.6451 L/kg 1compartment NA NA Rat Human +DTXSID8048733 Vd NA 0.428 L/kg 1compartment NA NA Rat Human +DTXSID8048733 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8048733 TK.Half.Life NA 13.69 hours 1compartment NA NA Rat Human +DTXSID8048733 Css NA 1.146 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048733 Css NA 8.059 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048733 Css NA 0.6572 mg/L PBTK NA 50% Rat Human +DTXSID8048733 Css NA 4.528 mg/L PBTK NA 95% Rat Human +DTXSID8048735 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048735 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048735 Vd NA 0.6687 L/kg 1compartment NA NA Human Human +DTXSID8048735 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8048735 TK.Half.Life NA 10.13 hours 1compartment NA NA Human Human +DTXSID8048735 Css NA 0.844 mg/L 3compartmentss NA 50% Human Human +DTXSID8048735 Css NA 4.326 mg/L 3compartmentss NA 95% Human Human +DTXSID8048735 Css NA 0.6733 mg/L PBTK NA 50% Human Human +DTXSID8048735 Css NA 2.837 mg/L PBTK NA 95% Human Human +DTXSID8048735 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048735 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048735 Vd NA 0.6753 L/kg 1compartment NA NA Rat Human DTXSID8048735 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048735 TK.Half.Life NA 1.023 hours 1compartment NA NA Rat Human -DTXSID8048735 Css NA 0.1343 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048735 Css NA 0.9062 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048735 Css NA 0.1023 mg/L PBTK NA 50% Rat Human -DTXSID8048735 Css NA 0.5329 mg/L PBTK NA 95% Rat Human -DTXSID8048737 Clint NA 23.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048737 Fup NA 0.0337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048737 Vd NA 0.5325 L/kg 1compartment NA NA Human Human +DTXSID8048735 TK.Half.Life NA 3.488 hours 1compartment NA NA Rat Human +DTXSID8048735 Css NA 0.004526 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048735 Css NA 0.02434 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048735 Css NA 0.003486 mg/L PBTK NA 50% Rat Human +DTXSID8048735 Css NA 0.01532 mg/L PBTK NA 95% Rat Human +DTXSID8048737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048737 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048737 Vd NA 2.672 L/kg 1compartment NA NA Human Human DTXSID8048737 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048737 TK.Half.Life NA 2.886 hours 1compartment NA NA Human Human -DTXSID8048737 Css NA 0.8878 mg/L 3compartmentss NA 50% Human Human -DTXSID8048737 Css NA 6.911 mg/L 3compartmentss NA 95% Human Human -DTXSID8048737 Css NA 0.5306 mg/L PBTK NA 50% Human Human -DTXSID8048737 Css NA 4.054 mg/L PBTK NA 95% Human Human -DTXSID8048737 Clint NA 23.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048737 Fup NA 0.0337 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048737 Vd NA 0.4219 L/kg 1compartment NA NA Rat Human +DTXSID8048737 TK.Half.Life NA 11.1 hours 1compartment NA NA Human Human +DTXSID8048737 Css NA 0.4338 mg/L 3compartmentss NA 50% Human Human +DTXSID8048737 Css NA 2.875 mg/L 3compartmentss NA 95% Human Human +DTXSID8048737 Css NA 0.3055 mg/L PBTK NA 50% Human Human +DTXSID8048737 Css NA 1.932 mg/L PBTK NA 95% Human Human +DTXSID8048737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048737 Fup 0.138 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048737 Vd NA 2.017 L/kg 1compartment NA NA Rat Human DTXSID8048737 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048737 TK.Half.Life NA 1.427 hours 1compartment NA NA Rat Human -DTXSID8048737 Css NA 0.5036 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048737 Css NA 2.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048737 Css NA 0.2824 mg/L PBTK NA 50% Rat Human -DTXSID8048737 Css NA 1.633 mg/L PBTK NA 95% Rat Human +DTXSID8048737 TK.Half.Life NA 2.663 hours 1compartment NA NA Rat Human +DTXSID8048737 Css NA 0.05543 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048737 Css NA 0.2901 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048737 Css NA 0.0385 mg/L PBTK NA 50% Rat Human +DTXSID8048737 Css NA 0.1954 mg/L PBTK NA 95% Rat Human DTXSID8048739 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8048739 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048739 Vd NA 0.9173 L/kg 1compartment NA NA Human Human +DTXSID8048739 Vd NA 1.035 L/kg 1compartment NA NA Human Human DTXSID8048739 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048739 TK.Half.Life NA 5.934 hours 1compartment NA NA Human Human -DTXSID8048739 Css NA 0.8129 mg/L 3compartmentss NA 50% Human Human -DTXSID8048739 Css NA 5.505 mg/L 3compartmentss NA 95% Human Human -DTXSID8048739 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID8048739 Css NA 3.574 mg/L PBTK NA 95% Human Human +DTXSID8048739 TK.Half.Life NA 6.697 hours 1compartment NA NA Human Human +DTXSID8048739 Css NA 0.4381 mg/L 3compartmentss NA 50% Human Human +DTXSID8048739 Css NA 2.995 mg/L 3compartmentss NA 95% Human Human +DTXSID8048739 Css NA 0.3839 mg/L PBTK NA 50% Human Human +DTXSID8048739 Css NA 2.013 mg/L PBTK NA 95% Human Human DTXSID8048739 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8048739 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048739 Vd NA 0.9615 L/kg 1compartment NA NA Rat Human +DTXSID8048739 Vd NA 1.068 L/kg 1compartment NA NA Rat Human DTXSID8048739 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048739 TK.Half.Life NA 2.12 hours 1compartment NA NA Rat Human -DTXSID8048739 Css NA 0.2036 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048739 Css NA 1.298 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048739 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID8048739 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID8048781 Clint NA 7.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048781 Fup NA 0.954 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048781 Vd NA 3.38 L/kg 1compartment NA NA Human Human -DTXSID8048781 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID8048781 TK.Half.Life NA 43.95 hours 1compartment NA NA Human Human -DTXSID8048781 Css NA 1.423 mg/L 3compartmentss NA 50% Human Human -DTXSID8048781 Css NA 8.939 mg/L 3compartmentss NA 95% Human Human -DTXSID8048781 Css NA 1.061 mg/L PBTK NA 50% Human Human -DTXSID8048781 Css NA 6.335 mg/L PBTK NA 95% Human Human -DTXSID8048781 Clint NA 7.855 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048781 Fup NA 0.954 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048781 Vd NA 2.628 L/kg 1compartment NA NA Rat Human -DTXSID8048781 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID8048781 TK.Half.Life NA 6.273 hours 1compartment NA NA Rat Human -DTXSID8048781 Css NA 0.7699 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048781 Css NA 3.896 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048781 Css NA 0.5563 mg/L PBTK NA 50% Rat Human -DTXSID8048781 Css NA 2.687 mg/L PBTK NA 95% Rat Human -DTXSID8048783 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048783 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048783 Vd NA 0.2015 L/kg 1compartment NA NA Human Human -DTXSID8048783 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID8048783 TK.Half.Life NA 50.74 hours 1compartment NA NA Human Human -DTXSID8048783 Css NA 43.34 mg/L 3compartmentss NA 50% Human Human -DTXSID8048783 Css NA 256.8 mg/L 3compartmentss NA 95% Human Human -DTXSID8048783 Css NA 25.55 mg/L PBTK NA 50% Human Human -DTXSID8048783 Css NA 147.9 mg/L PBTK NA 95% Human Human -DTXSID8048783 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048783 Fup NA 0.0257 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048783 Vd NA 0.198 L/kg 1compartment NA NA Rat Human -DTXSID8048783 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8048783 TK.Half.Life NA 16.98 hours 1compartment NA NA Rat Human -DTXSID8048783 Css NA 12.34 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048783 Css NA 63.58 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048783 Css NA 6.793 mg/L PBTK NA 50% Rat Human -DTXSID8048783 Css NA 34.46 mg/L PBTK NA 95% Rat Human +DTXSID8048739 TK.Half.Life NA 2.355 hours 1compartment NA NA Rat Human +DTXSID8048739 Css NA 0.002168 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048739 Css NA 0.01573 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048739 Css NA 0.00187 mg/L PBTK NA 50% Rat Human +DTXSID8048739 Css NA 0.01021 mg/L PBTK NA 95% Rat Human +DTXSID8048781 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048781 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048781 Vd NA 0.583 L/kg 1compartment NA NA Human Human +DTXSID8048781 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048781 TK.Half.Life NA 1.073 hours 1compartment NA NA Human Human +DTXSID8048781 Css NA 0.1427 mg/L 3compartmentss NA 50% Human Human +DTXSID8048781 Css NA 1.023 mg/L 3compartmentss NA 95% Human Human +DTXSID8048781 Css NA 0.09421 mg/L PBTK NA 50% Human Human +DTXSID8048781 Css NA 0.6355 mg/L PBTK NA 95% Human Human +DTXSID8048781 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048781 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048781 Vd NA 0.5844 L/kg 1compartment NA NA Rat Human +DTXSID8048781 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048781 TK.Half.Life NA 0.6096 hours 1compartment NA NA Rat Human +DTXSID8048781 Css NA 0.01826 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048781 Css NA 0.1002 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048781 Css NA 0.0119 mg/L PBTK NA 50% Rat Human +DTXSID8048781 Css NA 0.06251 mg/L PBTK NA 95% Rat Human +DTXSID8048783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048783 Fup 0.0999 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048783 Vd NA 0.3225 L/kg 1compartment NA NA Human Human +DTXSID8048783 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048783 TK.Half.Life NA 0.8363 hours 1compartment NA NA Human Human +DTXSID8048783 Css NA 0.2452 mg/L 3compartmentss NA 50% Human Human +DTXSID8048783 Css NA 2.091 mg/L 3compartmentss NA 95% Human Human +DTXSID8048783 Css NA 0.1548 mg/L PBTK NA 50% Human Human +DTXSID8048783 Css NA 1.255 mg/L PBTK NA 95% Human Human +DTXSID8048783 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048783 Fup 0.0999 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048783 Vd NA 0.3157 L/kg 1compartment NA NA Rat Human +DTXSID8048783 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048783 TK.Half.Life NA 0.4874 hours 1compartment NA NA Rat Human +DTXSID8048783 Css NA 0.008986 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048783 Css NA 0.08599 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048783 Css NA 0.005448 mg/L PBTK NA 50% Rat Human +DTXSID8048783 Css NA 0.04975 mg/L PBTK NA 95% Rat Human DTXSID8048785 Clint 3.236 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.31.5.580 NA Human Human DTXSID8048785 Fup 0.005 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Human Human -DTXSID8048785 Vd NA 0.7704 L/kg 1compartment NA NA Human Human -DTXSID8048785 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID8048785 TK.Half.Life NA 121.2 hours 1compartment NA NA Human Human -DTXSID8048785 Css NA 28.55 mg/L 3compartmentss NA 50% Human Human -DTXSID8048785 Css NA 222.2 mg/L 3compartmentss NA 95% Human Human -DTXSID8048785 Css NA 17.39 mg/L PBTK NA 50% Human Human -DTXSID8048785 Css NA 131.4 mg/L PBTK NA 95% Human Human +DTXSID8048785 Vd NA 0.5274 L/kg 1compartment NA NA Human Human +DTXSID8048785 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID8048785 TK.Half.Life NA 88.88 hours 1compartment NA NA Human Human +DTXSID8048785 Css NA 30.4 mg/L 3compartmentss NA 50% Human Human +DTXSID8048785 Css NA 231.8 mg/L 3compartmentss NA 95% Human Human +DTXSID8048785 Css NA 18.24 mg/L PBTK NA 50% Human Human +DTXSID8048785 Css NA 139.1 mg/L PBTK NA 95% Human Human DTXSID8048785 Clint 47.08 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat DTXSID8048785 Fup 0.01 NA NA https://doi.org/10.1124/dmd.31.5.580 NA Rat Rat -DTXSID8048785 Vd NA 0.8011 L/kg 1compartment NA NA Rat Rat +DTXSID8048785 Vd NA 0.5508 L/kg 1compartment NA NA Rat Rat DTXSID8048785 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID8048785 TK.Half.Life NA 3.473 hours 1compartment NA NA Rat Rat -DTXSID8048785 Css NA 0.4893 mg/L 3compartmentss NA 50% Rat Rat -DTXSID8048785 Css NA 3.868 mg/L 3compartmentss NA 95% Rat Rat -DTXSID8048785 Css NA 0.2776 mg/L PBTK NA 50% Rat Rat -DTXSID8048785 Css NA 2.17 mg/L PBTK NA 95% Rat Rat -DTXSID8048787 Clint NA 1.805 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048787 Fup NA 0.0213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048787 Vd NA 0.2908 L/kg 1compartment NA NA Human Human -DTXSID8048787 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8048787 TK.Half.Life NA 22.15 hours 1compartment NA NA Human Human -DTXSID8048787 Css NA 13.26 mg/L 3compartmentss NA 50% Human Human -DTXSID8048787 Css NA 96.71 mg/L 3compartmentss NA 95% Human Human -DTXSID8048787 Css NA 8.046 mg/L PBTK NA 50% Human Human -DTXSID8048787 Css NA 56.22 mg/L PBTK NA 95% Human Human -DTXSID8048787 Clint NA 1.805 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048787 Fup NA 0.0213 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048787 Vd NA 0.2807 L/kg 1compartment NA NA Rat Human -DTXSID8048787 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8048787 TK.Half.Life NA 11.83 hours 1compartment NA NA Rat Human -DTXSID8048787 Css NA 6.129 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048787 Css NA 35.97 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048787 Css NA 3.472 mg/L PBTK NA 50% Rat Human -DTXSID8048787 Css NA 19.56 mg/L PBTK NA 95% Rat Human -DTXSID8048789 Clint NA 3.756 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048789 Fup NA 0.1828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048789 Vd NA 0.5887 L/kg 1compartment NA NA Human Human +DTXSID8048785 TK.Half.Life NA 2.643 hours 1compartment NA NA Rat Rat +DTXSID8048785 Css NA 0.1555 mg/L 3compartmentss NA 50% Rat Rat +DTXSID8048785 Css NA 1.328 mg/L 3compartmentss NA 95% Rat Rat +DTXSID8048785 Css NA 0.0966 mg/L PBTK NA 50% Rat Rat +DTXSID8048785 Css NA 0.8252 mg/L PBTK NA 95% Rat Rat +DTXSID8048787 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048787 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048787 Vd NA 0.2862 L/kg 1compartment NA NA Human Human +DTXSID8048787 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8048787 TK.Half.Life NA 13.13 hours 1compartment NA NA Human Human +DTXSID8048787 Css NA 6.613 mg/L 3compartmentss NA 50% Human Human +DTXSID8048787 Css NA 29.45 mg/L 3compartmentss NA 95% Human Human +DTXSID8048787 Css NA 4.138 mg/L PBTK NA 50% Human Human +DTXSID8048787 Css NA 17.39 mg/L PBTK NA 95% Human Human +DTXSID8048787 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048787 Fup 0.141 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048787 Vd NA 0.2944 L/kg 1compartment NA NA Rat Human +DTXSID8048787 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048787 TK.Half.Life NA 4.603 hours 1compartment NA NA Rat Human +DTXSID8048787 Css NA 0.4298 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048787 Css NA 1.624 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048787 Css NA 0.2604 mg/L PBTK NA 50% Rat Human +DTXSID8048787 Css NA 0.929 mg/L PBTK NA 95% Rat Human +DTXSID8048789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048789 Fup 0.274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048789 Vd NA 0.7338 L/kg 1compartment NA NA Human Human DTXSID8048789 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048789 TK.Half.Life NA 3.257 hours 1compartment NA NA Human Human -DTXSID8048789 Css NA 0.6293 mg/L 3compartmentss NA 50% Human Human -DTXSID8048789 Css NA 3.224 mg/L 3compartmentss NA 95% Human Human -DTXSID8048789 Css NA 0.4223 mg/L PBTK NA 50% Human Human -DTXSID8048789 Css NA 2.036 mg/L PBTK NA 95% Human Human -DTXSID8048789 Clint NA 3.756 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048789 Fup NA 0.1828 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048789 Vd NA 0.5267 L/kg 1compartment NA NA Rat Human +DTXSID8048789 TK.Half.Life NA 1.01 hours 1compartment NA NA Human Human +DTXSID8048789 Css NA 0.07533 mg/L 3compartmentss NA 50% Human Human +DTXSID8048789 Css NA 0.5304 mg/L 3compartmentss NA 95% Human Human +DTXSID8048789 Css NA 0.05342 mg/L PBTK NA 50% Human Human +DTXSID8048789 Css NA 0.3546 mg/L PBTK NA 95% Human Human +DTXSID8048789 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048789 Fup 0.274 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048789 Vd NA 0.6579 L/kg 1compartment NA NA Rat Human DTXSID8048789 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048789 TK.Half.Life NA 1.668 hours 1compartment NA NA Rat Human -DTXSID8048789 Css NA 0.311 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048789 Css NA 1.173 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048789 Css NA 0.1968 mg/L PBTK NA 50% Rat Human -DTXSID8048789 Css NA 0.6879 mg/L PBTK NA 95% Rat Human -DTXSID8048810 Clint NA 0.1183 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048810 Fup NA 0.4963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048810 Vd NA 3.924 L/kg 1compartment NA NA Human Human -DTXSID8048810 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID8048810 TK.Half.Life NA 42.34 hours 1compartment NA NA Human Human -DTXSID8048810 Css NA 0.6517 mg/L 3compartmentss NA 50% Human Human -DTXSID8048810 Css NA 4.897 mg/L 3compartmentss NA 95% Human Human -DTXSID8048810 Css NA 0.8989 mg/L PBTK NA 50% Human Human -DTXSID8048810 Css NA 4.052 mg/L PBTK NA 95% Human Human -DTXSID8048810 Clint NA 0.1183 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048810 Fup NA 0.4963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048810 Vd NA 3.982 L/kg 1compartment NA NA Rat Human -DTXSID8048810 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8048810 TK.Half.Life NA 16.04 hours 1compartment NA NA Rat Human -DTXSID8048810 Css NA 0.188 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048810 Css NA 1.317 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048810 Css NA 0.2598 mg/L PBTK NA 50% Rat Human -DTXSID8048810 Css NA 1.004 mg/L PBTK NA 95% Rat Human -DTXSID8048812 Clint NA 455.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048812 Fup NA 0.0234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048812 Vd NA 0.6945 L/kg 1compartment NA NA Human Human +DTXSID8048789 TK.Half.Life NA 0.4804 hours 1compartment NA NA Rat Human +DTXSID8048789 Css NA 0.009357 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048789 Css NA 0.05479 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048789 Css NA 0.00663 mg/L PBTK NA 50% Rat Human +DTXSID8048789 Css NA 0.03566 mg/L PBTK NA 95% Rat Human +DTXSID8048810 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048810 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048810 Vd NA 3.278 L/kg 1compartment NA NA Human Human +DTXSID8048810 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048810 TK.Half.Life NA 5.64 hours 1compartment NA NA Human Human +DTXSID8048810 Css NA 0.09576 mg/L 3compartmentss NA 50% Human Human +DTXSID8048810 Css NA 0.7677 mg/L 3compartmentss NA 95% Human Human +DTXSID8048810 Css NA 0.1152 mg/L PBTK NA 50% Human Human +DTXSID8048810 Css NA 0.6885 mg/L PBTK NA 95% Human Human +DTXSID8048810 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048810 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048810 Vd NA 3.314 L/kg 1compartment NA NA Rat Human +DTXSID8048810 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048810 TK.Half.Life NA 3.336 hours 1compartment NA NA Rat Human +DTXSID8048810 Css NA 0.01082 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048810 Css NA 0.06877 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048810 Css NA 0.01352 mg/L PBTK NA 50% Rat Human +DTXSID8048810 Css NA 0.05807 mg/L PBTK NA 95% Rat Human +DTXSID8048812 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048812 Fup 0.0905 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048812 Vd NA 0.6893 L/kg 1compartment NA NA Human Human DTXSID8048812 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048812 TK.Half.Life NA 0.8868 hours 1compartment NA NA Human Human -DTXSID8048812 Css NA 0.06239 mg/L 3compartmentss NA 50% Human Human -DTXSID8048812 Css NA 0.6572 mg/L 3compartmentss NA 95% Human Human -DTXSID8048812 Css NA 0.03759 mg/L PBTK NA 50% Human Human -DTXSID8048812 Css NA 0.3845 mg/L PBTK NA 95% Human Human -DTXSID8048812 Clint NA 455.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048812 Fup NA 0.0234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048812 Vd NA 0.5387 L/kg 1compartment NA NA Rat Human +DTXSID8048812 TK.Half.Life NA 4.814 hours 1compartment NA NA Human Human +DTXSID8048812 Css NA 1.009 mg/L 3compartmentss NA 50% Human Human +DTXSID8048812 Css NA 6.799 mg/L 3compartmentss NA 95% Human Human +DTXSID8048812 Css NA 0.6362 mg/L PBTK NA 50% Human Human +DTXSID8048812 Css NA 4.089 mg/L PBTK NA 95% Human Human +DTXSID8048812 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048812 Fup 0.0905 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048812 Vd NA 0.5832 L/kg 1compartment NA NA Rat Human DTXSID8048812 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048812 TK.Half.Life NA 0.3423 hours 1compartment NA NA Rat Human -DTXSID8048812 Css NA 0.03652 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048812 Css NA 0.3181 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048812 Css NA 0.02064 mg/L PBTK NA 50% Rat Human -DTXSID8048812 Css NA 0.1767 mg/L PBTK NA 95% Rat Human -DTXSID8048814 Clint NA 15.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048814 Fup NA 0.0635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048814 Vd NA 1.973 L/kg 1compartment NA NA Human Human +DTXSID8048812 TK.Half.Life NA 2.43 hours 1compartment NA NA Rat Human +DTXSID8048812 Css NA 0.1235 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048812 Css NA 0.6407 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048812 Css NA 0.07611 mg/L PBTK NA 50% Rat Human +DTXSID8048812 Css NA 0.3748 mg/L PBTK NA 95% Rat Human +DTXSID8048814 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048814 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048814 Vd NA 2.27 L/kg 1compartment NA NA Human Human DTXSID8048814 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048814 TK.Half.Life NA 11.52 hours 1compartment NA NA Human Human -DTXSID8048814 Css NA 0.7856 mg/L 3compartmentss NA 50% Human Human -DTXSID8048814 Css NA 5.592 mg/L 3compartmentss NA 95% Human Human -DTXSID8048814 Css NA 0.5192 mg/L PBTK NA 50% Human Human -DTXSID8048814 Css NA 3.524 mg/L PBTK NA 95% Human Human -DTXSID8048814 Clint NA 15.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048814 Fup NA 0.0635 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048814 Vd NA 1.483 L/kg 1compartment NA NA Rat Human +DTXSID8048814 TK.Half.Life NA 7.847 hours 1compartment NA NA Human Human +DTXSID8048814 Css NA 0.3677 mg/L 3compartmentss NA 50% Human Human +DTXSID8048814 Css NA 2.607 mg/L 3compartmentss NA 95% Human Human +DTXSID8048814 Css NA 0.2521 mg/L PBTK NA 50% Human Human +DTXSID8048814 Css NA 1.702 mg/L PBTK NA 95% Human Human +DTXSID8048814 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048814 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048814 Vd NA 1.717 L/kg 1compartment NA NA Rat Human DTXSID8048814 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048814 TK.Half.Life NA 3.796 hours 1compartment NA NA Rat Human -DTXSID8048814 Css NA 0.4318 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048814 Css NA 2.234 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048814 Css NA 0.2699 mg/L PBTK NA 50% Rat Human -DTXSID8048814 Css NA 1.323 mg/L PBTK NA 95% Rat Human -DTXSID8048816 Clint NA 15.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048816 Fup NA 0.1775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048816 Vd NA 2.438 L/kg 1compartment NA NA Human Human +DTXSID8048814 TK.Half.Life NA 2.343 hours 1compartment NA NA Rat Human +DTXSID8048814 Css NA 0.04742 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048814 Css NA 0.258 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048814 Css NA 0.03205 mg/L PBTK NA 50% Rat Human +DTXSID8048814 Css NA 0.1656 mg/L PBTK NA 95% Rat Human +DTXSID8048816 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048816 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048816 Vd NA 1.097 L/kg 1compartment NA NA Human Human DTXSID8048816 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048816 TK.Half.Life NA 6.022 hours 1compartment NA NA Human Human -DTXSID8048816 Css NA 0.2008 mg/L 3compartmentss NA 50% Human Human -DTXSID8048816 Css NA 1.291 mg/L 3compartmentss NA 95% Human Human -DTXSID8048816 Css NA 0.1634 mg/L PBTK NA 50% Human Human -DTXSID8048816 Css NA 0.9664 mg/L PBTK NA 95% Human Human -DTXSID8048816 Clint NA 15.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048816 Fup NA 0.1775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048816 Vd NA 2.11 L/kg 1compartment NA NA Rat Human +DTXSID8048816 TK.Half.Life NA 2.163 hours 1compartment NA NA Human Human +DTXSID8048816 Css NA 0.1492 mg/L 3compartmentss NA 50% Human Human +DTXSID8048816 Css NA 1.032 mg/L 3compartmentss NA 95% Human Human +DTXSID8048816 Css NA 0.1191 mg/L PBTK NA 50% Human Human +DTXSID8048816 Css NA 0.7107 mg/L PBTK NA 95% Human Human +DTXSID8048816 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048816 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048816 Vd NA 1.102 L/kg 1compartment NA NA Rat Human DTXSID8048816 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048816 TK.Half.Life NA 2.501 hours 1compartment NA NA Rat Human -DTXSID8048816 Css NA 0.1083 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048816 Css NA 0.5268 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048816 Css NA 0.08472 mg/L PBTK NA 50% Rat Human -DTXSID8048816 Css NA 0.384 mg/L PBTK NA 95% Rat Human -DTXSID8048818 Clint NA 52.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048818 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048818 Vd NA 0.833 L/kg 1compartment NA NA Human Human +DTXSID8048816 TK.Half.Life NA 1.223 hours 1compartment NA NA Rat Human +DTXSID8048816 Css NA 0.01717 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048816 Css NA 0.09181 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048816 Css NA 0.01384 mg/L PBTK NA 50% Rat Human +DTXSID8048816 Css NA 0.0615 mg/L PBTK NA 95% Rat Human +DTXSID8048818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048818 Fup 0.0553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048818 Vd NA 0.9063 L/kg 1compartment NA NA Human Human DTXSID8048818 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048818 TK.Half.Life NA 3.495 hours 1compartment NA NA Human Human -DTXSID8048818 Css NA 0.5999 mg/L 3compartmentss NA 50% Human Human -DTXSID8048818 Css NA 6.019 mg/L 3compartmentss NA 95% Human Human -DTXSID8048818 Css NA 0.3659 mg/L PBTK NA 50% Human Human -DTXSID8048818 Css NA 3.606 mg/L PBTK NA 95% Human Human -DTXSID8048818 Clint NA 52.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048818 Fup NA 0.0202 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048818 Vd NA 0.626 L/kg 1compartment NA NA Rat Human +DTXSID8048818 TK.Half.Life NA 3.62 hours 1compartment NA NA Human Human +DTXSID8048818 Css NA 0.5278 mg/L 3compartmentss NA 50% Human Human +DTXSID8048818 Css NA 4.258 mg/L 3compartmentss NA 95% Human Human +DTXSID8048818 Css NA 0.3346 mg/L PBTK NA 50% Human Human +DTXSID8048818 Css NA 2.59 mg/L PBTK NA 95% Human Human +DTXSID8048818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048818 Fup 0.0553 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048818 Vd NA 0.6981 L/kg 1compartment NA NA Rat Human DTXSID8048818 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048818 TK.Half.Life NA 1.556 hours 1compartment NA NA Rat Human -DTXSID8048818 Css NA 0.3481 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048818 Css NA 2.891 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048818 Css NA 0.1985 mg/L PBTK NA 50% Rat Human -DTXSID8048818 Css NA 1.593 mg/L PBTK NA 95% Rat Human -DTXSID8048860 Clint NA 1.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048860 Fup NA 0.4817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048860 Vd NA 2.806 L/kg 1compartment NA NA Human Human -DTXSID8048860 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID8048860 TK.Half.Life NA 38.02 hours 1compartment NA NA Human Human -DTXSID8048860 Css NA 1.465 mg/L 3compartmentss NA 50% Human Human -DTXSID8048860 Css NA 6.124 mg/L 3compartmentss NA 95% Human Human -DTXSID8048860 Css NA 1.132 mg/L PBTK NA 50% Human Human -DTXSID8048860 Css NA 4.264 mg/L PBTK NA 95% Human Human -DTXSID8048860 Clint NA 1.619 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048860 Fup NA 0.4817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048860 Vd NA 2.16 L/kg 1compartment NA NA Rat Human -DTXSID8048860 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8048860 TK.Half.Life NA 6.931 hours 1compartment NA NA Rat Human -DTXSID8048860 Css NA 0.6578 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048860 Css NA 1.938 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048860 Css NA 0.4913 mg/L PBTK NA 50% Rat Human -DTXSID8048860 Css NA 1.254 mg/L PBTK NA 95% Rat Human +DTXSID8048818 TK.Half.Life NA 1.616 hours 1compartment NA NA Rat Human +DTXSID8048818 Css NA 0.06932 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048818 Css NA 0.439 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048818 Css NA 0.0425 mg/L PBTK NA 50% Rat Human +DTXSID8048818 Css NA 0.2578 mg/L PBTK NA 95% Rat Human +DTXSID8048860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048860 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048860 Vd NA 2.482 L/kg 1compartment NA NA Human Human +DTXSID8048860 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8048860 TK.Half.Life NA 5.432 hours 1compartment NA NA Human Human +DTXSID8048860 Css NA 0.169 mg/L 3compartmentss NA 50% Human Human +DTXSID8048860 Css NA 1.081 mg/L 3compartmentss NA 95% Human Human +DTXSID8048860 Css NA 0.1255 mg/L PBTK NA 50% Human Human +DTXSID8048860 Css NA 0.7651 mg/L PBTK NA 95% Human Human +DTXSID8048860 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048860 Fup 0.261 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048860 Vd NA 1.903 L/kg 1compartment NA NA Rat Human +DTXSID8048860 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048860 TK.Half.Life NA 1.556 hours 1compartment NA NA Rat Human +DTXSID8048860 Css NA 0.02119 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048860 Css NA 0.1051 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048860 Css NA 0.01567 mg/L PBTK NA 50% Rat Human +DTXSID8048860 Css NA 0.07506 mg/L PBTK NA 95% Rat Human DTXSID8048862 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8048862 Fup NA 0.7771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048862 Vd NA 0.5962 L/kg 1compartment NA NA Human Human -DTXSID8048862 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048862 TK.Half.Life NA 4.962 hours 1compartment NA NA Human Human -DTXSID8048862 Css NA 1.046 mg/L 3compartmentss NA 50% Human Human -DTXSID8048862 Css NA 6.139 mg/L 3compartmentss NA 95% Human Human -DTXSID8048862 Css NA 0.827 mg/L PBTK NA 50% Human Human -DTXSID8048862 Css NA 3.941 mg/L PBTK NA 95% Human Human +DTXSID8048862 Vd NA 3.486 L/kg 1compartment NA NA Human Human +DTXSID8048862 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8048862 TK.Half.Life NA 29.07 hours 1compartment NA NA Human Human +DTXSID8048862 Css NA 0.5818 mg/L 3compartmentss NA 50% Human Human +DTXSID8048862 Css NA 4.941 mg/L 3compartmentss NA 95% Human Human +DTXSID8048862 Css NA 0.8144 mg/L PBTK NA 50% Human Human +DTXSID8048862 Css NA 3.895 mg/L PBTK NA 95% Human Human DTXSID8048862 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8048862 Fup NA 0.7771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048862 Vd NA 0.64 L/kg 1compartment NA NA Rat Human -DTXSID8048862 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048862 TK.Half.Life NA 1.816 hours 1compartment NA NA Rat Human -DTXSID8048862 Css NA 0.2709 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048862 Css NA 1.685 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048862 Css NA 0.2065 mg/L PBTK NA 50% Rat Human -DTXSID8048862 Css NA 0.9883 mg/L PBTK NA 95% Rat Human -DTXSID8048864 Clint NA 14.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048864 Fup NA 0.6218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048864 Vd NA 3.583 L/kg 1compartment NA NA Human Human +DTXSID8048862 Vd NA 3.456 L/kg 1compartment NA NA Rat Human +DTXSID8048862 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8048862 TK.Half.Life NA 9.81 hours 1compartment NA NA Rat Human +DTXSID8048862 Css NA 0.0325 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048862 Css NA 0.2886 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048862 Css NA 0.0479 mg/L PBTK NA 50% Rat Human +DTXSID8048862 Css NA 0.219 mg/L PBTK NA 95% Rat Human +DTXSID8048864 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048864 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048864 Vd NA 3.497 L/kg 1compartment NA NA Human Human DTXSID8048864 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048864 TK.Half.Life NA 2.636 hours 1compartment NA NA Human Human -DTXSID8048864 Css NA 0.03026 mg/L 3compartmentss NA 50% Human Human -DTXSID8048864 Css NA 0.372 mg/L 3compartmentss NA 95% Human Human -DTXSID8048864 Css NA 0.03996 mg/L PBTK NA 50% Human Human -DTXSID8048864 Css NA 0.3258 mg/L PBTK NA 95% Human Human -DTXSID8048864 Clint NA 14.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048864 Fup NA 0.6218 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048864 Vd NA 3.6 L/kg 1compartment NA NA Rat Human +DTXSID8048864 TK.Half.Life NA 2.407 hours 1compartment NA NA Human Human +DTXSID8048864 Css NA 0.02053 mg/L 3compartmentss NA 50% Human Human +DTXSID8048864 Css NA 0.243 mg/L 3compartmentss NA 95% Human Human +DTXSID8048864 Css NA 0.02692 mg/L PBTK NA 50% Human Human +DTXSID8048864 Css NA 0.2252 mg/L PBTK NA 95% Human Human +DTXSID8048864 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048864 Fup 0.499 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048864 Vd NA 3.511 L/kg 1compartment NA NA Rat Human DTXSID8048864 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048864 TK.Half.Life NA 1.449 hours 1compartment NA NA Rat Human -DTXSID8048864 Css NA 0.01476 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048864 Css NA 0.1662 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048864 Css NA 0.01995 mg/L PBTK NA 50% Rat Human -DTXSID8048864 Css NA 0.1352 mg/L PBTK NA 95% Rat Human -DTXSID8048866 Clint NA 2.757 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048866 Fup NA 0.9863 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048866 Vd NA 2.87 L/kg 1compartment NA NA Human Human +DTXSID8048864 TK.Half.Life NA 1.298 hours 1compartment NA NA Rat Human +DTXSID8048864 Css NA 0.002468 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048864 Css NA 0.02374 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048864 Css NA 0.0034 mg/L PBTK NA 50% Rat Human +DTXSID8048864 Css NA 0.02128 mg/L PBTK NA 95% Rat Human +DTXSID8048866 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048866 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048866 Vd NA 2 L/kg 1compartment NA NA Human Human DTXSID8048866 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048866 TK.Half.Life NA 7.774 hours 1compartment NA NA Human Human -DTXSID8048866 Css NA 0.2195 mg/L 3compartmentss NA 50% Human Human -DTXSID8048866 Css NA 1.519 mg/L 3compartmentss NA 95% Human Human -DTXSID8048866 Css NA 0.2145 mg/L PBTK NA 50% Human Human -DTXSID8048866 Css NA 1.17 mg/L PBTK NA 95% Human Human -DTXSID8048866 Clint NA 2.757 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048866 Fup NA 0.9863 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048866 Vd NA 2.416 L/kg 1compartment NA NA Rat Human +DTXSID8048866 TK.Half.Life NA 2.759 hours 1compartment NA NA Human Human +DTXSID8048866 Css NA 0.07789 mg/L 3compartmentss NA 50% Human Human +DTXSID8048866 Css NA 0.5217 mg/L 3compartmentss NA 95% Human Human +DTXSID8048866 Css NA 0.06162 mg/L PBTK NA 50% Human Human +DTXSID8048866 Css NA 0.3816 mg/L PBTK NA 95% Human Human +DTXSID8048866 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048866 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048866 Vd NA 1.641 L/kg 1compartment NA NA Rat Human DTXSID8048866 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048866 TK.Half.Life NA 2.279 hours 1compartment NA NA Rat Human -DTXSID8048866 Css NA 0.09918 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048866 Css NA 0.526 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048866 Css NA 0.09582 mg/L PBTK NA 50% Rat Human -DTXSID8048866 Css NA 0.3762 mg/L PBTK NA 95% Rat Human -DTXSID8048868 Clint NA 15.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048868 Fup NA 0.4733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048868 Vd NA 2.951 L/kg 1compartment NA NA Human Human +DTXSID8048866 TK.Half.Life NA 1.049 hours 1compartment NA NA Rat Human +DTXSID8048866 Css NA 0.009621 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048866 Css NA 0.05146 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048866 Css NA 0.007656 mg/L PBTK NA 50% Rat Human +DTXSID8048866 Css NA 0.03748 mg/L PBTK NA 95% Rat Human +DTXSID8048868 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048868 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048868 Vd NA 2.533 L/kg 1compartment NA NA Human Human DTXSID8048868 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048868 TK.Half.Life NA 2.441 hours 1compartment NA NA Human Human -DTXSID8048868 Css NA 0.0323 mg/L 3compartmentss NA 50% Human Human -DTXSID8048868 Css NA 0.3296 mg/L 3compartmentss NA 95% Human Human -DTXSID8048868 Css NA 0.04036 mg/L PBTK NA 50% Human Human -DTXSID8048868 Css NA 0.2984 mg/L PBTK NA 95% Human Human -DTXSID8048868 Clint NA 15.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048868 Fup NA 0.4733 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048868 Vd NA 2.925 L/kg 1compartment NA NA Rat Human +DTXSID8048868 TK.Half.Life NA 2.139 hours 1compartment NA NA Human Human +DTXSID8048868 Css NA 0.02926 mg/L 3compartmentss NA 50% Human Human +DTXSID8048868 Css NA 0.2801 mg/L 3compartmentss NA 95% Human Human +DTXSID8048868 Css NA 0.03282 mg/L PBTK NA 50% Human Human +DTXSID8048868 Css NA 0.2457 mg/L PBTK NA 95% Human Human +DTXSID8048868 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048868 Fup 0.38 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048868 Vd NA 2.504 L/kg 1compartment NA NA Rat Human DTXSID8048868 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048868 TK.Half.Life NA 1.332 hours 1compartment NA NA Rat Human -DTXSID8048868 Css NA 0.01633 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048868 Css NA 0.1369 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048868 Css NA 0.02062 mg/L PBTK NA 50% Rat Human -DTXSID8048868 Css NA 0.1188 mg/L PBTK NA 95% Rat Human -DTXSID8048941 Clint NA 8.207 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048941 Fup NA 0.5902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048941 Vd NA 4.041 L/kg 1compartment NA NA Human Human +DTXSID8048868 TK.Half.Life NA 1.146 hours 1compartment NA NA Rat Human +DTXSID8048868 Css NA 0.003567 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048868 Css NA 0.0257 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048868 Css NA 0.004166 mg/L PBTK NA 50% Rat Human +DTXSID8048868 Css NA 0.02285 mg/L PBTK NA 95% Rat Human +DTXSID8048941 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048941 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048941 Vd NA 2.109 L/kg 1compartment NA NA Human Human DTXSID8048941 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048941 TK.Half.Life NA 4.404 hours 1compartment NA NA Human Human -DTXSID8048941 Css NA 0.05669 mg/L 3compartmentss NA 50% Human Human -DTXSID8048941 Css NA 0.6429 mg/L 3compartmentss NA 95% Human Human -DTXSID8048941 Css NA 0.07344 mg/L PBTK NA 50% Human Human -DTXSID8048941 Css NA 0.5574 mg/L PBTK NA 95% Human Human -DTXSID8048941 Clint NA 8.207 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048941 Fup NA 0.5902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048941 Vd NA 4.092 L/kg 1compartment NA NA Rat Human +DTXSID8048941 TK.Half.Life NA 3.959 hours 1compartment NA NA Human Human +DTXSID8048941 Css NA 0.1248 mg/L 3compartmentss NA 50% Human Human +DTXSID8048941 Css NA 0.9457 mg/L 3compartmentss NA 95% Human Human +DTXSID8048941 Css NA 0.1193 mg/L PBTK NA 50% Human Human +DTXSID8048941 Css NA 0.7246 mg/L PBTK NA 95% Human Human +DTXSID8048941 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048941 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048941 Vd NA 2.127 L/kg 1compartment NA NA Rat Human DTXSID8048941 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048941 TK.Half.Life NA 2.445 hours 1compartment NA NA Rat Human -DTXSID8048941 Css NA 0.0274 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048941 Css NA 0.268 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048941 Css NA 0.03592 mg/L PBTK NA 50% Rat Human -DTXSID8048941 Css NA 0.2075 mg/L PBTK NA 95% Rat Human -DTXSID8048943 Clint NA 31.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048943 Fup NA 0.022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048943 Vd NA 1.552 L/kg 1compartment NA NA Human Human -DTXSID8048943 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048943 TK.Half.Life NA 9.529 hours 1compartment NA NA Human Human -DTXSID8048943 Css NA 0.9368 mg/L 3compartmentss NA 50% Human Human -DTXSID8048943 Css NA 8.153 mg/L 3compartmentss NA 95% Human Human -DTXSID8048943 Css NA 0.5938 mg/L PBTK NA 50% Human Human -DTXSID8048943 Css NA 4.937 mg/L PBTK NA 95% Human Human -DTXSID8048943 Clint NA 31.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048943 Fup NA 0.022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048943 Vd NA 1.18 L/kg 1compartment NA NA Rat Human +DTXSID8048941 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human +DTXSID8048941 Css NA 0.01431 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048941 Css NA 0.08149 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048941 Css NA 0.01399 mg/L PBTK NA 50% Rat Human +DTXSID8048941 Css NA 0.06079 mg/L PBTK NA 95% Rat Human +DTXSID8048943 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048943 Fup 0.0751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048943 Vd NA 2.723 L/kg 1compartment NA NA Human Human +DTXSID8048943 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8048943 TK.Half.Life NA 18.38 hours 1compartment NA NA Human Human +DTXSID8048943 Css NA 0.7958 mg/L 3compartmentss NA 50% Human Human +DTXSID8048943 Css NA 5.053 mg/L 3compartmentss NA 95% Human Human +DTXSID8048943 Css NA 0.5443 mg/L PBTK NA 50% Human Human +DTXSID8048943 Css NA 3.316 mg/L PBTK NA 95% Human Human +DTXSID8048943 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048943 Fup 0.0751 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048943 Vd NA 2.046 L/kg 1compartment NA NA Rat Human DTXSID8048943 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048943 TK.Half.Life NA 3.784 hours 1compartment NA NA Rat Human -DTXSID8048943 Css NA 0.5129 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048943 Css NA 3.812 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048943 Css NA 0.3046 mg/L PBTK NA 50% Rat Human -DTXSID8048943 Css NA 2.183 mg/L PBTK NA 95% Rat Human +DTXSID8048943 TK.Half.Life NA 4.049 hours 1compartment NA NA Rat Human +DTXSID8048943 Css NA 0.1027 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048943 Css NA 0.536 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048943 Css NA 0.06958 mg/L PBTK NA 50% Rat Human +DTXSID8048943 Css NA 0.3509 mg/L PBTK NA 95% Rat Human DTXSID8048945 Clint 13.83 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID8048945 Fup NA 0.0095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048945 Vd NA 0.5924 L/kg 1compartment NA NA Human Human +DTXSID8048945 Fup 0.028 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048945 Vd NA 1.586 L/kg 1compartment NA NA Human Human DTXSID8048945 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8048945 TK.Half.Life NA 14.94 hours 1compartment NA NA Human Human -DTXSID8048945 Css NA 4.644 mg/L 3compartmentss NA 50% Human Human -DTXSID8048945 Css NA 42.84 mg/L 3compartmentss NA 95% Human Human -DTXSID8048945 Css NA 2.758 mg/L PBTK NA 50% Human Human -DTXSID8048945 Css NA 25.19 mg/L PBTK NA 95% Human Human +DTXSID8048945 TK.Half.Life NA 17.27 hours 1compartment NA NA Human Human +DTXSID8048945 Css NA 1.697 mg/L 3compartmentss NA 50% Human Human +DTXSID8048945 Css NA 14.19 mg/L 3compartmentss NA 95% Human Human +DTXSID8048945 Css NA 1.078 mg/L PBTK NA 50% Human Human +DTXSID8048945 Css NA 8.752 mg/L PBTK NA 95% Human Human DTXSID8048945 Clint 13.83 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID8048945 Fup NA 0.0095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048945 Vd NA 0.446 L/kg 1compartment NA NA Rat Human +DTXSID8048945 Fup 0.028 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048945 Vd NA 1.18 L/kg 1compartment NA NA Rat Human DTXSID8048945 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048945 TK.Half.Life NA 7.193 hours 1compartment NA NA Rat Human -DTXSID8048945 Css NA 2.601 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048945 Css NA 19.39 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048945 Css NA 1.438 mg/L PBTK NA 50% Rat Human -DTXSID8048945 Css NA 10.6 mg/L PBTK NA 95% Rat Human +DTXSID8048945 TK.Half.Life NA 6.43 hours 1compartment NA NA Rat Human +DTXSID8048945 Css NA 0.215 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048945 Css NA 1.414 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048945 Css NA 0.1332 mg/L PBTK NA 50% Rat Human +DTXSID8048945 Css NA 0.8328 mg/L PBTK NA 95% Rat Human DTXSID8048947 Clint 0.9947 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID8048947 Fup NA 0.0843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048947 Vd NA 3.108 L/kg 1compartment NA NA Human Human -DTXSID8048947 Days.Css NA 199 Days PBTK NA NA Human Human -DTXSID8048947 TK.Half.Life NA 806.5 hours 1compartment NA NA Human Human -DTXSID8048947 Css NA 32.13 mg/L 3compartmentss NA 50% Human Human -DTXSID8048947 Css NA 138.4 mg/L 3compartmentss NA 95% Human Human -DTXSID8048947 Css NA 22.52 mg/L PBTK NA 50% Human Human -DTXSID8048947 Css NA 92.95 mg/L PBTK NA 95% Human Human +DTXSID8048947 Fup 0.0489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048947 Vd NA 1.951 L/kg 1compartment NA NA Human Human +DTXSID8048947 Days.Css NA 25 Days PBTK NA NA Human Human +DTXSID8048947 TK.Half.Life NA 130.7 hours 1compartment NA NA Human Human +DTXSID8048947 Css NA 8.535 mg/L 3compartmentss NA 50% Human Human +DTXSID8048947 Css NA 42.4 mg/L 3compartmentss NA 95% Human Human +DTXSID8048947 Css NA 5.7 mg/L PBTK NA 50% Human Human +DTXSID8048947 Css NA 26 mg/L PBTK NA 95% Human Human DTXSID8048947 Clint 0.9947 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID8048947 Fup NA 0.0843 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048947 Vd NA 2.346 L/kg 1compartment NA NA Rat Human -DTXSID8048947 Days.Css NA 94 Days PBTK NA NA Rat Human -DTXSID8048947 TK.Half.Life NA 100.9 hours 1compartment NA NA Rat Human -DTXSID8048947 Css NA 15.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048947 Css NA 46.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048947 Css NA 10.49 mg/L PBTK NA 50% Rat Human -DTXSID8048947 Css NA 29.68 mg/L PBTK NA 95% Rat Human -DTXSID8048949 Clint NA 72.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8048947 Fup 0.0489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048947 Vd NA 1.519 L/kg 1compartment NA NA Rat Human +DTXSID8048947 Days.Css NA 10 Days PBTK NA NA Rat Human +DTXSID8048947 TK.Half.Life NA 37.69 hours 1compartment NA NA Rat Human +DTXSID8048947 Css NA 0.3209 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048947 Css NA 1.973 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048947 Css NA 0.2074 mg/L PBTK NA 50% Rat Human +DTXSID8048947 Css NA 1.186 mg/L PBTK NA 95% Rat Human +DTXSID8048949 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8048949 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8048949 Vd NA 4.015 L/kg 1compartment NA NA Human Human -DTXSID8048949 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048949 TK.Half.Life NA 3.244 hours 1compartment NA NA Human Human -DTXSID8048949 Css NA 0.02454 mg/L 3compartmentss NA 50% Human Human -DTXSID8048949 Css NA 0.1745 mg/L 3compartmentss NA 95% Human Human -DTXSID8048949 Css NA 0.02518 mg/L PBTK NA 50% Human Human -DTXSID8048949 Css NA 0.1586 mg/L PBTK NA 95% Human Human -DTXSID8048949 Clint NA 72.27 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8048949 Vd NA 3.129 L/kg 1compartment NA NA Human Human +DTXSID8048949 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8048949 TK.Half.Life NA 51 hours 1compartment NA NA Human Human +DTXSID8048949 Css NA 1.836 mg/L 3compartmentss NA 50% Human Human +DTXSID8048949 Css NA 11.9 mg/L 3compartmentss NA 95% Human Human +DTXSID8048949 Css NA 1.283 mg/L PBTK NA 50% Human Human +DTXSID8048949 Css NA 8.177 mg/L PBTK NA 95% Human Human +DTXSID8048949 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8048949 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8048949 Vd NA 3.655 L/kg 1compartment NA NA Rat Human -DTXSID8048949 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048949 TK.Half.Life NA 1.247 hours 1compartment NA NA Rat Human -DTXSID8048949 Css NA 0.01321 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048949 Css NA 0.0783 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048949 Css NA 0.0134 mg/L PBTK NA 50% Rat Human -DTXSID8048949 Css NA 0.07045 mg/L PBTK NA 95% Rat Human +DTXSID8048949 Vd NA 2.347 L/kg 1compartment NA NA Rat Human +DTXSID8048949 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID8048949 TK.Half.Life NA 7.048 hours 1compartment NA NA Rat Human +DTXSID8048949 Css NA 0.2375 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048949 Css NA 1.292 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048949 Css NA 0.1652 mg/L PBTK NA 50% Rat Human +DTXSID8048949 Css NA 0.8689 mg/L PBTK NA 95% Rat Human DTXSID8048991 Clint NA 226.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8048991 Fup NA 0.4123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048991 Vd NA 1.931 L/kg 1compartment NA NA Human Human +DTXSID8048991 Vd NA 0.6262 L/kg 1compartment NA NA Human Human DTXSID8048991 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048991 TK.Half.Life NA 1.177 hours 1compartment NA NA Human Human -DTXSID8048991 Css NA 0.004025 mg/L 3compartmentss NA 50% Human Human -DTXSID8048991 Css NA 0.03675 mg/L 3compartmentss NA 95% Human Human -DTXSID8048991 Css NA 0.003716 mg/L PBTK NA 50% Human Human -DTXSID8048991 Css NA 0.02893 mg/L PBTK NA 95% Human Human +DTXSID8048991 TK.Half.Life NA 0.479 hours 1compartment NA NA Human Human +DTXSID8048991 Css NA 0.001972 mg/L 3compartmentss NA 50% Human Human +DTXSID8048991 Css NA 0.03179 mg/L 3compartmentss NA 95% Human Human +DTXSID8048991 Css NA 0.001461 mg/L PBTK NA 50% Human Human +DTXSID8048991 Css NA 0.02122 mg/L PBTK NA 95% Human Human DTXSID8048991 Clint NA 226.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8048991 Fup NA 0.4123 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048991 Vd NA 1.945 L/kg 1compartment NA NA Rat Human +DTXSID8048991 Vd NA 0.6073 L/kg 1compartment NA NA Rat Human DTXSID8048991 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048991 TK.Half.Life NA 0.5332 hours 1compartment NA NA Rat Human -DTXSID8048991 Css NA 0.002126 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048991 Css NA 0.01642 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048991 Css NA 0.001946 mg/L PBTK NA 50% Rat Human -DTXSID8048991 Css NA 0.01206 mg/L PBTK NA 95% Rat Human -DTXSID8048995 Clint NA 0.8889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048995 Fup NA 0.3742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048995 Vd NA 0.3403 L/kg 1compartment NA NA Human Human +DTXSID8048991 TK.Half.Life NA 0.2068 hours 1compartment NA NA Rat Human +DTXSID8048991 Css NA 6.184e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048991 Css NA 0.00139 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048991 Css NA 4.554e-05 mg/L PBTK NA 50% Rat Human +DTXSID8048991 Css NA 0.0009057 mg/L PBTK NA 95% Rat Human +DTXSID8048995 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048995 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048995 Vd NA 0.3691 L/kg 1compartment NA NA Human Human DTXSID8048995 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048995 TK.Half.Life NA 2.443 hours 1compartment NA NA Human Human -DTXSID8048995 Css NA 0.8429 mg/L 3compartmentss NA 50% Human Human -DTXSID8048995 Css NA 3.829 mg/L 3compartmentss NA 95% Human Human -DTXSID8048995 Css NA 0.568 mg/L PBTK NA 50% Human Human -DTXSID8048995 Css NA 2.363 mg/L PBTK NA 95% Human Human -DTXSID8048995 Clint NA 0.8889 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048995 Fup NA 0.3742 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048995 Vd NA 0.3492 L/kg 1compartment NA NA Rat Human +DTXSID8048995 TK.Half.Life NA 5.259 hours 1compartment NA NA Human Human +DTXSID8048995 Css NA 0.9142 mg/L 3compartmentss NA 50% Human Human +DTXSID8048995 Css NA 4.48 mg/L 3compartmentss NA 95% Human Human +DTXSID8048995 Css NA 0.6414 mg/L PBTK NA 50% Human Human +DTXSID8048995 Css NA 2.761 mg/L PBTK NA 95% Human Human +DTXSID8048995 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048995 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048995 Vd NA 0.3798 L/kg 1compartment NA NA Rat Human DTXSID8048995 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048995 TK.Half.Life NA 1.21 hours 1compartment NA NA Rat Human -DTXSID8048995 Css NA 0.3338 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048995 Css NA 1.273 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048995 Css NA 0.2145 mg/L PBTK NA 50% Rat Human -DTXSID8048995 Css NA 0.7331 mg/L PBTK NA 95% Rat Human -DTXSID8048997 Clint NA 4.027 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048997 Fup NA 0.2195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048997 Vd NA 2.857 L/kg 1compartment NA NA Human Human -DTXSID8048997 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8048997 TK.Half.Life NA 21.38 hours 1compartment NA NA Human Human -DTXSID8048997 Css NA 0.7439 mg/L 3compartmentss NA 50% Human Human -DTXSID8048997 Css NA 3.733 mg/L 3compartmentss NA 95% Human Human -DTXSID8048997 Css NA 0.6096 mg/L PBTK NA 50% Human Human -DTXSID8048997 Css NA 2.761 mg/L PBTK NA 95% Human Human -DTXSID8048997 Clint NA 4.027 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048997 Fup NA 0.2195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048997 Vd NA 2.39 L/kg 1compartment NA NA Rat Human -DTXSID8048997 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8048997 TK.Half.Life NA 6.62 hours 1compartment NA NA Rat Human -DTXSID8048997 Css NA 0.3644 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048997 Css NA 1.331 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048997 Css NA 0.2893 mg/L PBTK NA 50% Rat Human -DTXSID8048997 Css NA 0.9309 mg/L PBTK NA 95% Rat Human -DTXSID8048999 Clint NA 29.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048999 Fup NA 0.0267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8048999 Vd NA 0.4892 L/kg 1compartment NA NA Human Human +DTXSID8048995 TK.Half.Life NA 1.845 hours 1compartment NA NA Rat Human +DTXSID8048995 Css NA 0.005012 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048995 Css NA 0.02401 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048995 Css NA 0.00332 mg/L PBTK NA 50% Rat Human +DTXSID8048995 Css NA 0.01436 mg/L PBTK NA 95% Rat Human +DTXSID8048997 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048997 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048997 Vd NA 1.618 L/kg 1compartment NA NA Human Human +DTXSID8048997 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID8048997 TK.Half.Life NA 26.37 hours 1compartment NA NA Human Human +DTXSID8048997 Css NA 1.463 mg/L 3compartmentss NA 50% Human Human +DTXSID8048997 Css NA 7.11 mg/L 3compartmentss NA 95% Human Human +DTXSID8048997 Css NA 1.31 mg/L PBTK NA 50% Human Human +DTXSID8048997 Css NA 4.934 mg/L PBTK NA 95% Human Human +DTXSID8048997 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048997 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048997 Vd NA 1.624 L/kg 1compartment NA NA Rat Human +DTXSID8048997 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8048997 TK.Half.Life NA 9.019 hours 1compartment NA NA Rat Human +DTXSID8048997 Css NA 0.09132 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048997 Css NA 0.3867 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048997 Css NA 0.08238 mg/L PBTK NA 50% Rat Human +DTXSID8048997 Css NA 0.2586 mg/L PBTK NA 95% Rat Human +DTXSID8048999 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048999 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8048999 Vd NA 0.8766 L/kg 1compartment NA NA Human Human DTXSID8048999 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8048999 TK.Half.Life NA 2.711 hours 1compartment NA NA Human Human -DTXSID8048999 Css NA 0.8836 mg/L 3compartmentss NA 50% Human Human -DTXSID8048999 Css NA 8.837 mg/L 3compartmentss NA 95% Human Human -DTXSID8048999 Css NA 0.5296 mg/L PBTK NA 50% Human Human -DTXSID8048999 Css NA 5.166 mg/L PBTK NA 95% Human Human -DTXSID8048999 Clint NA 29.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048999 Fup NA 0.0267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8048999 Vd NA 0.3891 L/kg 1compartment NA NA Rat Human +DTXSID8048999 TK.Half.Life NA 2.556 hours 1compartment NA NA Human Human +DTXSID8048999 Css NA 0.339 mg/L 3compartmentss NA 50% Human Human +DTXSID8048999 Css NA 2.706 mg/L 3compartmentss NA 95% Human Human +DTXSID8048999 Css NA 0.215 mg/L PBTK NA 50% Human Human +DTXSID8048999 Css NA 1.66 mg/L PBTK NA 95% Human Human +DTXSID8048999 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048999 Fup 0.0849 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8048999 Vd NA 0.6931 L/kg 1compartment NA NA Rat Human DTXSID8048999 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8048999 TK.Half.Life NA 1.358 hours 1compartment NA NA Rat Human -DTXSID8048999 Css NA 0.4959 mg/L 3compartmentss NA 50% Rat Human -DTXSID8048999 Css NA 3.806 mg/L 3compartmentss NA 95% Rat Human -DTXSID8048999 Css NA 0.2777 mg/L PBTK NA 50% Rat Human -DTXSID8048999 Css NA 2.083 mg/L PBTK NA 95% Rat Human -DTXSID8049040 Clint NA 11.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049040 Fup NA 0.1279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049040 Vd NA 3.084 L/kg 1compartment NA NA Human Human +DTXSID8048999 TK.Half.Life NA 1.154 hours 1compartment NA NA Rat Human +DTXSID8048999 Css NA 0.04394 mg/L 3compartmentss NA 50% Rat Human +DTXSID8048999 Css NA 0.2694 mg/L 3compartmentss NA 95% Rat Human +DTXSID8048999 Css NA 0.02731 mg/L PBTK NA 50% Rat Human +DTXSID8048999 Css NA 0.1601 mg/L PBTK NA 95% Rat Human +DTXSID8049040 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049040 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049040 Vd NA 1.32 L/kg 1compartment NA NA Human Human DTXSID8049040 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049040 TK.Half.Life NA 7.326 hours 1compartment NA NA Human Human -DTXSID8049040 Css NA 0.2042 mg/L 3compartmentss NA 50% Human Human -DTXSID8049040 Css NA 1.792 mg/L 3compartmentss NA 95% Human Human -DTXSID8049040 Css NA 0.1899 mg/L PBTK NA 50% Human Human -DTXSID8049040 Css NA 1.336 mg/L PBTK NA 95% Human Human -DTXSID8049040 Clint NA 11.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049040 Fup NA 0.1279 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049040 Vd NA 2.987 L/kg 1compartment NA NA Rat Human +DTXSID8049040 TK.Half.Life NA 3.07 hours 1compartment NA NA Human Human +DTXSID8049040 Css NA 0.1829 mg/L 3compartmentss NA 50% Human Human +DTXSID8049040 Css NA 1.21 mg/L 3compartmentss NA 95% Human Human +DTXSID8049040 Css NA 0.1489 mg/L PBTK NA 50% Human Human +DTXSID8049040 Css NA 0.8671 mg/L PBTK NA 95% Human Human +DTXSID8049040 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049040 Fup 0.321 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049040 Vd NA 1.326 L/kg 1compartment NA NA Rat Human DTXSID8049040 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049040 TK.Half.Life NA 3.952 hours 1compartment NA NA Rat Human -DTXSID8049040 Css NA 0.1086 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049040 Css NA 0.7482 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049040 Css NA 0.09818 mg/L PBTK NA 50% Rat Human -DTXSID8049040 Css NA 0.5481 mg/L PBTK NA 95% Rat Human -DTXSID8049042 Clint NA 1.671 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049042 Fup NA 0.3362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049042 Vd NA 1.605 L/kg 1compartment NA NA Human Human +DTXSID8049040 TK.Half.Life NA 1.777 hours 1compartment NA NA Rat Human +DTXSID8049040 Css NA 0.02126 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049040 Css NA 0.1068 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049040 Css NA 0.01752 mg/L PBTK NA 50% Rat Human +DTXSID8049040 Css NA 0.07329 mg/L PBTK NA 95% Rat Human +DTXSID8049042 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049042 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049042 Vd NA 0.358 L/kg 1compartment NA NA Human Human DTXSID8049042 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049042 TK.Half.Life NA 10.06 hours 1compartment NA NA Human Human -DTXSID8049042 Css NA 0.6272 mg/L 3compartmentss NA 50% Human Human -DTXSID8049042 Css NA 2.973 mg/L 3compartmentss NA 95% Human Human -DTXSID8049042 Css NA 0.5045 mg/L PBTK NA 50% Human Human -DTXSID8049042 Css NA 2.043 mg/L PBTK NA 95% Human Human -DTXSID8049042 Clint NA 1.671 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049042 Fup NA 0.3362 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049042 Vd NA 1.382 L/kg 1compartment NA NA Rat Human +DTXSID8049042 TK.Half.Life NA 0.9392 hours 1compartment NA NA Human Human +DTXSID8049042 Css NA 0.2457 mg/L 3compartmentss NA 50% Human Human +DTXSID8049042 Css NA 1.47 mg/L 3compartmentss NA 95% Human Human +DTXSID8049042 Css NA 0.1628 mg/L PBTK NA 50% Human Human +DTXSID8049042 Css NA 0.9243 mg/L PBTK NA 95% Human Human +DTXSID8049042 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049042 Fup 0.295 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049042 Vd NA 0.3584 L/kg 1compartment NA NA Rat Human DTXSID8049042 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049042 TK.Half.Life NA 4.053 hours 1compartment NA NA Rat Human -DTXSID8049042 Css NA 0.2734 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049042 Css NA 1.041 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049042 Css NA 0.2125 mg/L PBTK NA 50% Rat Human -DTXSID8049042 Css NA 0.6583 mg/L PBTK NA 95% Rat Human -DTXSID8049044 Clint NA 0.9797 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049044 Fup NA 0.063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049044 Vd NA 0.2298 L/kg 1compartment NA NA Human Human +DTXSID8049042 TK.Half.Life NA 0.5352 hours 1compartment NA NA Rat Human +DTXSID8049042 Css NA 0.02894 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049042 Css NA 0.1284 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049042 Css NA 0.01886 mg/L PBTK NA 50% Rat Human +DTXSID8049042 Css NA 0.07706 mg/L PBTK NA 95% Rat Human +DTXSID8049044 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049044 Fup 0.199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049044 Vd NA 0.3316 L/kg 1compartment NA NA Human Human DTXSID8049044 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049044 TK.Half.Life NA 9.071 hours 1compartment NA NA Human Human -DTXSID8049044 Css NA 6.658 mg/L 3compartmentss NA 50% Human Human -DTXSID8049044 Css NA 33.37 mg/L 3compartmentss NA 95% Human Human -DTXSID8049044 Css NA 3.984 mg/L PBTK NA 50% Human Human -DTXSID8049044 Css NA 19.4 mg/L PBTK NA 95% Human Human -DTXSID8049044 Clint NA 0.9797 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049044 Fup NA 0.063 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049044 Vd NA 0.2252 L/kg 1compartment NA NA Rat Human +DTXSID8049044 TK.Half.Life NA 1.19 hours 1compartment NA NA Human Human +DTXSID8049044 Css NA 0.3716 mg/L 3compartmentss NA 50% Human Human +DTXSID8049044 Css NA 2.35 mg/L 3compartmentss NA 95% Human Human +DTXSID8049044 Css NA 0.2384 mg/L PBTK NA 50% Human Human +DTXSID8049044 Css NA 1.434 mg/L PBTK NA 95% Human Human +DTXSID8049044 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049044 Fup 0.199 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049044 Vd NA 0.3293 L/kg 1compartment NA NA Rat Human DTXSID8049044 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049044 TK.Half.Life NA 4.423 hours 1compartment NA NA Rat Human -DTXSID8049044 Css NA 2.781 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049044 Css NA 10.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049044 Css NA 1.555 mg/L PBTK NA 50% Rat Human -DTXSID8049044 Css NA 5.932 mg/L PBTK NA 95% Rat Human -DTXSID8049046 Clint NA 11.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049046 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049046 Vd NA 3.028 L/kg 1compartment NA NA Human Human -DTXSID8049046 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID8049046 TK.Half.Life NA 121.1 hours 1compartment NA NA Human Human -DTXSID8049046 Css NA 5.114 mg/L 3compartmentss NA 50% Human Human -DTXSID8049046 Css NA 34.58 mg/L 3compartmentss NA 95% Human Human -DTXSID8049046 Css NA 3.513 mg/L PBTK NA 50% Human Human -DTXSID8049046 Css NA 22.72 mg/L PBTK NA 95% Human Human -DTXSID8049046 Clint NA 11.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049046 Fup NA 0.0172 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049046 Vd NA 2.269 L/kg 1compartment NA NA Rat Human -DTXSID8049046 Days.Css NA 12 Days PBTK NA NA Rat Human -DTXSID8049046 TK.Half.Life NA 18.35 hours 1compartment NA NA Rat Human -DTXSID8049046 Css NA 2.872 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049046 Css NA 15.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049046 Css NA 1.885 mg/L PBTK NA 50% Rat Human -DTXSID8049046 Css NA 9.719 mg/L PBTK NA 95% Rat Human -DTXSID8049048 Clint NA 5.094 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID8049044 TK.Half.Life NA 0.6925 hours 1compartment NA NA Rat Human +DTXSID8049044 Css NA 0.045 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049044 Css NA 0.188 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049044 Css NA 0.02831 mg/L PBTK NA 50% Rat Human +DTXSID8049044 Css NA 0.1117 mg/L PBTK NA 95% Rat Human +DTXSID8049046 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049046 Fup 0.015 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049046 Vd NA 3.01 L/kg 1compartment NA NA Human Human +DTXSID8049046 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID8049046 TK.Half.Life NA 66.97 hours 1compartment NA NA Human Human +DTXSID8049046 Css NA 2.758 mg/L 3compartmentss NA 50% Human Human +DTXSID8049046 Css NA 18.69 mg/L 3compartmentss NA 95% Human Human +DTXSID8049046 Css NA 1.896 mg/L PBTK NA 50% Human Human +DTXSID8049046 Css NA 12.21 mg/L PBTK NA 95% Human Human +DTXSID8049046 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049046 Fup 0.015 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049046 Vd NA 2.255 L/kg 1compartment NA NA Rat Human +DTXSID8049046 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID8049046 TK.Half.Life NA 10.58 hours 1compartment NA NA Rat Human +DTXSID8049046 Css NA 0.3587 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049046 Css NA 2.051 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049046 Css NA 0.2446 mg/L PBTK NA 50% Rat Human +DTXSID8049046 Css NA 1.365 mg/L PBTK NA 95% Rat Human +DTXSID8049048 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID8049048 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID8049048 Vd NA 2.505 L/kg 1compartment NA NA Human Human -DTXSID8049048 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8049048 TK.Half.Life NA 21.8 hours 1compartment NA NA Human Human -DTXSID8049048 Css NA 1.132 mg/L 3compartmentss NA 50% Human Human -DTXSID8049048 Css NA 8.556 mg/L 3compartmentss NA 95% Human Human -DTXSID8049048 Css NA 0.8624 mg/L PBTK NA 50% Human Human -DTXSID8049048 Css NA 5.756 mg/L PBTK NA 95% Human Human -DTXSID8049048 Clint NA 5.094 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID8049048 Vd NA 2.117 L/kg 1compartment NA NA Human Human +DTXSID8049048 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8049048 TK.Half.Life NA 5.879 hours 1compartment NA NA Human Human +DTXSID8049048 Css NA 0.2926 mg/L 3compartmentss NA 50% Human Human +DTXSID8049048 Css NA 2.765 mg/L 3compartmentss NA 95% Human Human +DTXSID8049048 Css NA 0.2201 mg/L PBTK NA 50% Human Human +DTXSID8049048 Css NA 1.865 mg/L PBTK NA 95% Human Human +DTXSID8049048 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID8049048 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID8049048 Vd NA 2.224 L/kg 1compartment NA NA Rat Human -DTXSID8049048 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8049048 TK.Half.Life NA 9.913 hours 1compartment NA NA Rat Human -DTXSID8049048 Css NA 0.6067 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049048 Css NA 3.778 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049048 Css NA 0.4413 mg/L PBTK NA 50% Rat Human -DTXSID8049048 Css NA 2.378 mg/L PBTK NA 95% Rat Human -DTXSID8049200 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049200 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049200 Vd NA 2.278 L/kg 1compartment NA NA Human Human -DTXSID8049200 Days.Css NA 22 Days PBTK NA NA Human Human -DTXSID8049200 TK.Half.Life NA 120.4 hours 1compartment NA NA Human Human -DTXSID8049200 Css NA 5.766 mg/L 3compartmentss NA 50% Human Human -DTXSID8049200 Css NA 18.35 mg/L 3compartmentss NA 95% Human Human -DTXSID8049200 Css NA 4.315 mg/L PBTK NA 50% Human Human -DTXSID8049200 Css NA 12.3 mg/L PBTK NA 95% Human Human -DTXSID8049200 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049200 Fup NA 0.2651 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049200 Vd NA 1.758 L/kg 1compartment NA NA Rat Human -DTXSID8049200 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID8049200 TK.Half.Life NA 18.69 hours 1compartment NA NA Rat Human -DTXSID8049200 Css NA 1.568 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049200 Css NA 4.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049200 Css NA 1.13 mg/L PBTK NA 50% Rat Human -DTXSID8049200 Css NA 2.563 mg/L PBTK NA 95% Rat Human -DTXSID8049202 Clint NA 17.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049202 Fup NA 0.0398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049202 Vd NA 1.758 L/kg 1compartment NA NA Human Human -DTXSID8049202 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049202 TK.Half.Life NA 12.59 hours 1compartment NA NA Human Human -DTXSID8049202 Css NA 1.059 mg/L 3compartmentss NA 50% Human Human -DTXSID8049202 Css NA 8.489 mg/L 3compartmentss NA 95% Human Human -DTXSID8049202 Css NA 0.6843 mg/L PBTK NA 50% Human Human -DTXSID8049202 Css NA 5.251 mg/L PBTK NA 95% Human Human -DTXSID8049202 Clint NA 17.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049202 Fup NA 0.0398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049202 Vd NA 1.314 L/kg 1compartment NA NA Rat Human -DTXSID8049202 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049202 TK.Half.Life NA 4.466 hours 1compartment NA NA Rat Human -DTXSID8049202 Css NA 0.5951 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049202 Css NA 3.737 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049202 Css NA 0.3593 mg/L PBTK NA 50% Rat Human -DTXSID8049202 Css NA 2.166 mg/L PBTK NA 95% Rat Human -DTXSID8049206 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049206 Fup NA 0.818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049206 Vd NA 0.6054 L/kg 1compartment NA NA Human Human -DTXSID8049206 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049206 TK.Half.Life NA 4.787 hours 1compartment NA NA Human Human -DTXSID8049206 Css NA 1.002 mg/L 3compartmentss NA 50% Human Human -DTXSID8049206 Css NA 6.138 mg/L 3compartmentss NA 95% Human Human -DTXSID8049206 Css NA 0.799 mg/L PBTK NA 50% Human Human -DTXSID8049206 Css NA 3.937 mg/L PBTK NA 95% Human Human -DTXSID8049206 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049206 Fup NA 0.818 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049206 Vd NA 0.6525 L/kg 1compartment NA NA Rat Human -DTXSID8049206 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049206 TK.Half.Life NA 1.758 hours 1compartment NA NA Rat Human -DTXSID8049206 Css NA 0.2599 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049206 Css NA 1.523 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049206 Css NA 0.1993 mg/L PBTK NA 50% Rat Human -DTXSID8049206 Css NA 0.8992 mg/L PBTK NA 95% Rat Human -DTXSID8049208 Clint NA 6.521 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049208 Fup NA 0.2711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049208 Vd NA 1.881 L/kg 1compartment NA NA Human Human +DTXSID8049048 Vd NA 1.954 L/kg 1compartment NA NA Rat Human +DTXSID8049048 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8049048 TK.Half.Life NA 3.066 hours 1compartment NA NA Rat Human +DTXSID8049048 Css NA 0.03828 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049048 Css NA 0.2813 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049048 Css NA 0.02824 mg/L PBTK NA 50% Rat Human +DTXSID8049048 Css NA 0.182 mg/L PBTK NA 95% Rat Human +DTXSID8049208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049208 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049208 Vd NA 1.202 L/kg 1compartment NA NA Human Human DTXSID8049208 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049208 TK.Half.Life NA 6.545 hours 1compartment NA NA Human Human -DTXSID8049208 Css NA 0.3319 mg/L 3compartmentss NA 50% Human Human -DTXSID8049208 Css NA 1.945 mg/L 3compartmentss NA 95% Human Human -DTXSID8049208 Css NA 0.25 mg/L PBTK NA 50% Human Human -DTXSID8049208 Css NA 1.332 mg/L PBTK NA 95% Human Human -DTXSID8049208 Clint NA 6.521 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049208 Fup NA 0.2711 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049208 Vd NA 1.476 L/kg 1compartment NA NA Rat Human +DTXSID8049208 TK.Half.Life NA 3.194 hours 1compartment NA NA Human Human +DTXSID8049208 Css NA 0.281 mg/L 3compartmentss NA 50% Human Human +DTXSID8049208 Css NA 2.218 mg/L 3compartmentss NA 95% Human Human +DTXSID8049208 Css NA 0.1847 mg/L PBTK NA 50% Human Human +DTXSID8049208 Css NA 1.39 mg/L PBTK NA 95% Human Human +DTXSID8049208 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049208 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049208 Vd NA 0.9336 L/kg 1compartment NA NA Rat Human DTXSID8049208 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049208 TK.Half.Life NA 2.311 hours 1compartment NA NA Rat Human -DTXSID8049208 Css NA 0.1707 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049208 Css NA 0.7006 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049208 Css NA 0.1237 mg/L PBTK NA 50% Rat Human -DTXSID8049208 Css NA 0.4648 mg/L PBTK NA 95% Rat Human -DTXSID8049250 Clint NA 226.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049250 Fup NA 0.096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049250 Vd NA 3.13 L/kg 1compartment NA NA Human Human -DTXSID8049250 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049250 TK.Half.Life NA 8.841 hours 1compartment NA NA Human Human -DTXSID8049250 Css NA 0.2496 mg/L 3compartmentss NA 50% Human Human -DTXSID8049250 Css NA 1.613 mg/L 3compartmentss NA 95% Human Human -DTXSID8049250 Css NA 0.1741 mg/L PBTK NA 50% Human Human -DTXSID8049250 Css NA 1.081 mg/L PBTK NA 95% Human Human -DTXSID8049250 Clint NA 226.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049250 Fup NA 0.096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049250 Vd NA 2.348 L/kg 1compartment NA NA Rat Human -DTXSID8049250 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049250 TK.Half.Life NA 1.652 hours 1compartment NA NA Rat Human -DTXSID8049250 Css NA 0.1399 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049250 Css NA 0.7239 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049250 Css NA 0.0932 mg/L PBTK NA 50% Rat Human -DTXSID8049250 Css NA 0.477 mg/L PBTK NA 95% Rat Human -DTXSID8049254 Clint NA 196.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049254 Fup NA 0.1852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049254 Vd NA 3.138 L/kg 1compartment NA NA Human Human -DTXSID8049254 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049254 TK.Half.Life NA 9.723 hours 1compartment NA NA Human Human -DTXSID8049254 Css NA 0.2824 mg/L 3compartmentss NA 50% Human Human -DTXSID8049254 Css NA 1.774 mg/L 3compartmentss NA 95% Human Human -DTXSID8049254 Css NA 0.1968 mg/L PBTK NA 50% Human Human -DTXSID8049254 Css NA 1.212 mg/L PBTK NA 95% Human Human -DTXSID8049254 Clint NA 196.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049254 Fup NA 0.1852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049254 Vd NA 2.355 L/kg 1compartment NA NA Rat Human -DTXSID8049254 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049254 TK.Half.Life NA 1.755 hours 1compartment NA NA Rat Human -DTXSID8049254 Css NA 0.1574 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049254 Css NA 0.8269 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049254 Css NA 0.1052 mg/L PBTK NA 50% Rat Human -DTXSID8049254 Css NA 0.5288 mg/L PBTK NA 95% Rat Human -DTXSID8049331 Clint NA 0.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049331 Fup NA 0.5595 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049331 Vd NA 0.7662 L/kg 1compartment NA NA Human Human +DTXSID8049208 TK.Half.Life NA 1.334 hours 1compartment NA NA Rat Human +DTXSID8049208 Css NA 0.03696 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049208 Css NA 0.2224 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049208 Css NA 0.02362 mg/L PBTK NA 50% Rat Human +DTXSID8049208 Css NA 0.1339 mg/L PBTK NA 95% Rat Human +DTXSID8049331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049331 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049331 Vd NA 0.3804 L/kg 1compartment NA NA Human Human DTXSID8049331 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049331 TK.Half.Life NA 6.925 hours 1compartment NA NA Human Human -DTXSID8049331 Css NA 0.9678 mg/L 3compartmentss NA 50% Human Human -DTXSID8049331 Css NA 6.67 mg/L 3compartmentss NA 95% Human Human -DTXSID8049331 Css NA 0.7802 mg/L PBTK NA 50% Human Human -DTXSID8049331 Css NA 4.265 mg/L PBTK NA 95% Human Human -DTXSID8049331 Clint NA 0.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049331 Fup NA 0.5595 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049331 Vd NA 0.7518 L/kg 1compartment NA NA Rat Human +DTXSID8049331 TK.Half.Life NA 0.7544 hours 1compartment NA NA Human Human +DTXSID8049331 Css NA 0.1718 mg/L 3compartmentss NA 50% Human Human +DTXSID8049331 Css NA 1.312 mg/L 3compartmentss NA 95% Human Human +DTXSID8049331 Css NA 0.1093 mg/L PBTK NA 50% Human Human +DTXSID8049331 Css NA 0.8059 mg/L PBTK NA 95% Human Human +DTXSID8049331 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049331 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049331 Vd NA 0.3701 L/kg 1compartment NA NA Rat Human DTXSID8049331 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049331 TK.Half.Life NA 2.598 hours 1compartment NA NA Rat Human -DTXSID8049331 Css NA 0.2978 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049331 Css NA 1.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049331 Css NA 0.2301 mg/L PBTK NA 50% Rat Human -DTXSID8049331 Css NA 1.155 mg/L PBTK NA 95% Rat Human -DTXSID8049333 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049333 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049333 Vd NA 3.157 L/kg 1compartment NA NA Human Human -DTXSID8049333 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049333 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human -DTXSID8049333 Css NA 0.3557 mg/L 3compartmentss NA 50% Human Human -DTXSID8049333 Css NA 2.326 mg/L 3compartmentss NA 95% Human Human -DTXSID8049333 Css NA 0.2508 mg/L PBTK NA 50% Human Human -DTXSID8049333 Css NA 1.568 mg/L PBTK NA 95% Human Human -DTXSID8049333 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049333 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049333 Vd NA 2.375 L/kg 1compartment NA NA Rat Human -DTXSID8049333 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049333 TK.Half.Life NA 2.005 hours 1compartment NA NA Rat Human -DTXSID8049333 Css NA 0.199 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049333 Css NA 1.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049333 Css NA 0.1344 mg/L PBTK NA 50% Rat Human -DTXSID8049333 Css NA 0.7061 mg/L PBTK NA 95% Rat Human -DTXSID8049337 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049337 Fup NA 0.817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049337 Vd NA 0.6405 L/kg 1compartment NA NA Human Human +DTXSID8049331 TK.Half.Life NA 0.4178 hours 1compartment NA NA Rat Human +DTXSID8049331 Css NA 0.02236 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049331 Css NA 0.1378 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049331 Css NA 0.01388 mg/L PBTK NA 50% Rat Human +DTXSID8049331 Css NA 0.08189 mg/L PBTK NA 95% Rat Human +DTXSID8049337 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049337 Fup 0.534 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049337 Vd NA 0.5769 L/kg 1compartment NA NA Human Human DTXSID8049337 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049337 TK.Half.Life NA 5.097 hours 1compartment NA NA Human Human -DTXSID8049337 Css NA 1.025 mg/L 3compartmentss NA 50% Human Human -DTXSID8049337 Css NA 6.016 mg/L 3compartmentss NA 95% Human Human -DTXSID8049337 Css NA 0.805 mg/L PBTK NA 50% Human Human -DTXSID8049337 Css NA 3.833 mg/L PBTK NA 95% Human Human -DTXSID8049337 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049337 Fup NA 0.817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049337 Vd NA 0.6428 L/kg 1compartment NA NA Rat Human +DTXSID8049337 TK.Half.Life NA 0.5762 hours 1compartment NA NA Human Human +DTXSID8049337 Css NA 0.03102 mg/L 3compartmentss NA 50% Human Human +DTXSID8049337 Css NA 0.3113 mg/L 3compartmentss NA 95% Human Human +DTXSID8049337 Css NA 0.02298 mg/L PBTK NA 50% Human Human +DTXSID8049337 Css NA 0.2033 mg/L PBTK NA 95% Human Human +DTXSID8049337 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049337 Fup 0.534 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049337 Vd NA 0.563 L/kg 1compartment NA NA Rat Human DTXSID8049337 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049337 TK.Half.Life NA 1.736 hours 1compartment NA NA Rat Human -DTXSID8049337 Css NA 0.2653 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049337 Css NA 1.532 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049337 Css NA 0.201 mg/L PBTK NA 50% Rat Human -DTXSID8049337 Css NA 0.9016 mg/L PBTK NA 95% Rat Human -DTXSID8049381 Clint NA 0.5434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049381 Fup NA 0.7502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049381 Vd NA 1.354 L/kg 1compartment NA NA Human Human -DTXSID8049381 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049381 TK.Half.Life NA 6.46 hours 1compartment NA NA Human Human -DTXSID8049381 Css NA 0.4989 mg/L 3compartmentss NA 50% Human Human -DTXSID8049381 Css NA 3.277 mg/L 3compartmentss NA 95% Human Human -DTXSID8049381 Css NA 0.4522 mg/L PBTK NA 50% Human Human -DTXSID8049381 Css NA 2.194 mg/L PBTK NA 95% Human Human -DTXSID8049381 Clint NA 0.5434 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049381 Fup NA 0.7502 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049381 Vd NA 1.327 L/kg 1compartment NA NA Rat Human -DTXSID8049381 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049381 TK.Half.Life NA 2.756 hours 1compartment NA NA Rat Human -DTXSID8049381 Css NA 0.1656 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049381 Css NA 1.183 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049381 Css NA 0.1482 mg/L PBTK NA 50% Rat Human -DTXSID8049381 Css NA 0.728 mg/L PBTK NA 95% Rat Human -DTXSID8049383 Clint NA 4.296 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049383 Fup NA 0.6106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049383 Vd NA 1.246 L/kg 1compartment NA NA Human Human -DTXSID8049383 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049383 TK.Half.Life NA 2.349 hours 1compartment NA NA Human Human -DTXSID8049383 Css NA 0.1574 mg/L 3compartmentss NA 50% Human Human -DTXSID8049383 Css NA 1.366 mg/L 3compartmentss NA 95% Human Human -DTXSID8049383 Css NA 0.1332 mg/L PBTK NA 50% Human Human -DTXSID8049383 Css NA 0.9291 mg/L PBTK NA 95% Human Human -DTXSID8049383 Clint NA 4.296 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049383 Fup NA 0.6106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049383 Vd NA 1.103 L/kg 1compartment NA NA Rat Human -DTXSID8049383 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049383 TK.Half.Life NA 1.075 hours 1compartment NA NA Rat Human -DTXSID8049383 Css NA 0.07515 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049383 Css NA 0.5599 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049383 Css NA 0.06188 mg/L PBTK NA 50% Rat Human -DTXSID8049383 Css NA 0.3461 mg/L PBTK NA 95% Rat Human +DTXSID8049337 TK.Half.Life NA 0.2797 hours 1compartment NA NA Rat Human +DTXSID8049337 Css NA 0.001106 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049337 Css NA 0.01295 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049337 Css NA 0.0008074 mg/L PBTK NA 50% Rat Human +DTXSID8049337 Css NA 0.008248 mg/L PBTK NA 95% Rat Human DTXSID8049387 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8049387 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049387 Vd NA 802.8 L/kg 1compartment NA NA Human Human +DTXSID8049387 Vd NA 4.98 L/kg 1compartment NA NA Human Human DTXSID8049387 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID8049387 TK.Half.Life NA 38510000 hours 1compartment NA NA Human Human -DTXSID8049387 Css NA 29.94 mg/L 3compartmentss NA 50% Human Human -DTXSID8049387 Css NA 79.26 mg/L 3compartmentss NA 95% Human Human -DTXSID8049387 Css NA 3728 mg/L PBTK NA 50% Human Human -DTXSID8049387 Css NA 8075 mg/L PBTK NA 95% Human Human +DTXSID8049387 TK.Half.Life NA 238900 hours 1compartment NA NA Human Human +DTXSID8049387 Css NA 2483 mg/L 3compartmentss NA 50% Human Human +DTXSID8049387 Css NA 6329 mg/L 3compartmentss NA 95% Human Human +DTXSID8049387 Css NA 2016 mg/L PBTK NA 50% Human Human +DTXSID8049387 Css NA 4867 mg/L PBTK NA 95% Human Human DTXSID8049387 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8049387 Fup NA 0.0043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049387 Vd NA 732.5 L/kg 1compartment NA NA Rat Human -DTXSID8049387 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID8049387 TK.Half.Life NA 3136000 hours 1compartment NA NA Rat Human -DTXSID8049387 Css NA 7.303 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049387 Css NA 12.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049387 Css NA 1006 mg/L PBTK NA 50% Rat Human -DTXSID8049387 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID8049387 Vd NA 3.803 L/kg 1compartment NA NA Rat Human +DTXSID8049387 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID8049387 TK.Half.Life NA 16290 hours 1compartment NA NA Rat Human +DTXSID8049387 Css NA 12.88 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049387 Css NA 34.44 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049387 Css NA 10.12 mg/L PBTK NA 50% Rat Human +DTXSID8049387 Css NA 26 mg/L PBTK NA 95% Rat Human DTXSID8049410 Clint NA 1.451 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8049410 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8049410 Vd NA 0.8907 L/kg 1compartment NA NA Human Human DTXSID8049410 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID8049410 TK.Half.Life NA 1.946 hours 1compartment NA NA Human Human -DTXSID8049410 Css NA 0.2408 mg/L 3compartmentss NA 50% Human Human -DTXSID8049410 Css NA 1.758 mg/L 3compartmentss NA 95% Human Human -DTXSID8049410 Css NA 0.2077 mg/L PBTK NA 50% Human Human -DTXSID8049410 Css NA 1.205 mg/L PBTK NA 95% Human Human +DTXSID8049410 Css NA 0.2005 mg/L 3compartmentss NA 50% Human Human +DTXSID8049410 Css NA 1.519 mg/L 3compartmentss NA 95% Human Human +DTXSID8049410 Css NA 0.1726 mg/L PBTK NA 50% Human Human +DTXSID8049410 Css NA 1.043 mg/L PBTK NA 95% Human Human DTXSID8049410 Clint NA 1.451 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8049410 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8049410 Vd NA 0.9124 L/kg 1compartment NA NA Rat Human DTXSID8049410 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID8049410 TK.Half.Life NA 0.9939 hours 1compartment NA NA Rat Human -DTXSID8049410 Css NA 0.0958 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049410 Css NA 0.6327 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049410 Css NA 0.08175 mg/L PBTK NA 50% Rat Human -DTXSID8049410 Css NA 0.3899 mg/L PBTK NA 95% Rat Human -DTXSID8049412 Clint NA 0.3943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049412 Fup NA 0.6418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049412 Vd NA 0.9397 L/kg 1compartment NA NA Human Human +DTXSID8049410 Css NA 0.005497 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049410 Css NA 0.0528 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049410 Css NA 0.004666 mg/L PBTK NA 50% Rat Human +DTXSID8049410 Css NA 0.03462 mg/L PBTK NA 95% Rat Human +DTXSID8049412 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049412 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049412 Vd NA 0.6944 L/kg 1compartment NA NA Human Human DTXSID8049412 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049412 TK.Half.Life NA 5.955 hours 1compartment NA NA Human Human -DTXSID8049412 Css NA 0.665 mg/L 3compartmentss NA 50% Human Human -DTXSID8049412 Css NA 4.641 mg/L 3compartmentss NA 95% Human Human -DTXSID8049412 Css NA 0.5601 mg/L PBTK NA 50% Human Human -DTXSID8049412 Css NA 3.022 mg/L PBTK NA 95% Human Human -DTXSID8049412 Clint NA 0.3943 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049412 Fup NA 0.6418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049412 Vd NA 0.8994 L/kg 1compartment NA NA Rat Human +DTXSID8049412 TK.Half.Life NA 0.7954 hours 1compartment NA NA Human Human +DTXSID8049412 Css NA 0.05042 mg/L 3compartmentss NA 50% Human Human +DTXSID8049412 Css NA 0.4044 mg/L 3compartmentss NA 95% Human Human +DTXSID8049412 Css NA 0.0376 mg/L PBTK NA 50% Human Human +DTXSID8049412 Css NA 0.2697 mg/L PBTK NA 95% Human Human +DTXSID8049412 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049412 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049412 Vd NA 0.6621 L/kg 1compartment NA NA Rat Human DTXSID8049412 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049412 TK.Half.Life NA 2.371 hours 1compartment NA NA Rat Human -DTXSID8049412 Css NA 0.221 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049412 Css NA 1.516 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049412 Css NA 0.1806 mg/L PBTK NA 50% Rat Human -DTXSID8049412 Css NA 0.9063 mg/L PBTK NA 95% Rat Human -DTXSID8049414 Clint NA 6.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049414 Fup NA 0.0462 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049414 Vd NA 2.241 L/kg 1compartment NA NA Human Human -DTXSID8049414 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID8049414 TK.Half.Life NA 39.27 hours 1compartment NA NA Human Human -DTXSID8049414 Css NA 2.572 mg/L 3compartmentss NA 50% Human Human -DTXSID8049414 Css NA 15.28 mg/L 3compartmentss NA 95% Human Human -DTXSID8049414 Css NA 1.698 mg/L PBTK NA 50% Human Human -DTXSID8049414 Css NA 9.615 mg/L PBTK NA 95% Human Human -DTXSID8049414 Clint NA 6.966 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049414 Fup NA 0.0462 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049414 Vd NA 1.678 L/kg 1compartment NA NA Rat Human -DTXSID8049414 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8049414 TK.Half.Life NA 10.98 hours 1compartment NA NA Rat Human -DTXSID8049414 Css NA 1.361 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049414 Css NA 6.047 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049414 Css NA 0.8531 mg/L PBTK NA 50% Rat Human -DTXSID8049414 Css NA 3.619 mg/L PBTK NA 95% Rat Human -DTXSID8049416 Clint NA 2.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049416 Fup NA 0.3551 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049416 Vd NA 0.367 L/kg 1compartment NA NA Human Human -DTXSID8049416 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8049416 TK.Half.Life NA 1.422 hours 1compartment NA NA Human Human -DTXSID8049416 Css NA 0.4188 mg/L 3compartmentss NA 50% Human Human -DTXSID8049416 Css NA 2.213 mg/L 3compartmentss NA 95% Human Human -DTXSID8049416 Css NA 0.2832 mg/L PBTK NA 50% Human Human -DTXSID8049416 Css NA 1.377 mg/L PBTK NA 95% Human Human -DTXSID8049416 Clint NA 2.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049416 Fup NA 0.3551 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049416 Vd NA 0.3707 L/kg 1compartment NA NA Rat Human +DTXSID8049412 TK.Half.Life NA 0.3916 hours 1compartment NA NA Rat Human +DTXSID8049412 Css NA 0.006297 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049412 Css NA 0.03886 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049412 Css NA 0.004695 mg/L PBTK NA 50% Rat Human +DTXSID8049412 Css NA 0.0258 mg/L PBTK NA 95% Rat Human +DTXSID8049414 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049414 Fup 0.0314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049414 Vd NA 2.309 L/kg 1compartment NA NA Human Human +DTXSID8049414 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8049414 TK.Half.Life NA 19.78 hours 1compartment NA NA Human Human +DTXSID8049414 Css NA 1.173 mg/L 3compartmentss NA 50% Human Human +DTXSID8049414 Css NA 9.634 mg/L 3compartmentss NA 95% Human Human +DTXSID8049414 Css NA 0.7707 mg/L PBTK NA 50% Human Human +DTXSID8049414 Css NA 5.981 mg/L PBTK NA 95% Human Human +DTXSID8049414 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049414 Fup 0.0314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049414 Vd NA 1.725 L/kg 1compartment NA NA Rat Human +DTXSID8049414 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8049414 TK.Half.Life NA 5.523 hours 1compartment NA NA Rat Human +DTXSID8049414 Css NA 0.1531 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049414 Css NA 0.9315 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049414 Css NA 0.09858 mg/L PBTK NA 50% Rat Human +DTXSID8049414 Css NA 0.5714 mg/L PBTK NA 95% Rat Human +DTXSID8049416 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049416 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049416 Vd NA 0.6618 L/kg 1compartment NA NA Human Human +DTXSID8049416 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8049416 TK.Half.Life NA 10.35 hours 1compartment NA NA Human Human +DTXSID8049416 Css NA 1.678 mg/L 3compartmentss NA 50% Human Human +DTXSID8049416 Css NA 7.349 mg/L 3compartmentss NA 95% Human Human +DTXSID8049416 Css NA 1.266 mg/L PBTK NA 50% Human Human +DTXSID8049416 Css NA 4.745 mg/L PBTK NA 95% Human Human +DTXSID8049416 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049416 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049416 Vd NA 0.6451 L/kg 1compartment NA NA Rat Human DTXSID8049416 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049416 TK.Half.Life NA 0.7879 hours 1compartment NA NA Rat Human -DTXSID8049416 Css NA 0.1964 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049416 Css NA 0.7845 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049416 Css NA 0.1266 mg/L PBTK NA 50% Rat Human -DTXSID8049416 Css NA 0.4553 mg/L PBTK NA 95% Rat Human -DTXSID8049418 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049418 Fup NA 0.8869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8049418 Vd NA 1.641 L/kg 1compartment NA NA Human Human -DTXSID8049418 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8049418 TK.Half.Life NA 14.15 hours 1compartment NA NA Human Human -DTXSID8049418 Css NA 0.8752 mg/L 3compartmentss NA 50% Human Human -DTXSID8049418 Css NA 5.13 mg/L 3compartmentss NA 95% Human Human -DTXSID8049418 Css NA 0.8318 mg/L PBTK NA 50% Human Human -DTXSID8049418 Css NA 3.579 mg/L PBTK NA 95% Human Human -DTXSID8049418 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049418 Fup NA 0.8869 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8049418 Vd NA 1.455 L/kg 1compartment NA NA Rat Human +DTXSID8049416 TK.Half.Life NA 3.411 hours 1compartment NA NA Rat Human +DTXSID8049416 Css NA 0.1065 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049416 Css NA 0.4078 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049416 Css NA 0.07963 mg/L PBTK NA 50% Rat Human +DTXSID8049416 Css NA 0.2524 mg/L PBTK NA 95% Rat Human +DTXSID8049418 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049418 Fup 0.562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8049418 Vd NA 1.272 L/kg 1compartment NA NA Human Human +DTXSID8049418 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8049418 TK.Half.Life NA 1.177 hours 1compartment NA NA Human Human +DTXSID8049418 Css NA 0.02796 mg/L 3compartmentss NA 50% Human Human +DTXSID8049418 Css NA 0.3431 mg/L 3compartmentss NA 95% Human Human +DTXSID8049418 Css NA 0.02361 mg/L PBTK NA 50% Human Human +DTXSID8049418 Css NA 0.2345 mg/L PBTK NA 95% Human Human +DTXSID8049418 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049418 Fup 0.562 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8049418 Vd NA 1.122 L/kg 1compartment NA NA Rat Human DTXSID8049418 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8049418 TK.Half.Life NA 3.775 hours 1compartment NA NA Rat Human -DTXSID8049418 Css NA 0.2249 mg/L 3compartmentss NA 50% Rat Human -DTXSID8049418 Css NA 1.395 mg/L 3compartmentss NA 95% Rat Human -DTXSID8049418 Css NA 0.2089 mg/L PBTK NA 50% Rat Human -DTXSID8049418 Css NA 0.8819 mg/L PBTK NA 95% Rat Human -DTXSID8051544 Clint NA 0.3856 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051544 Fup NA 0.7671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051544 Vd NA 1.931 L/kg 1compartment NA NA Human Human -DTXSID8051544 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8051544 TK.Half.Life NA 10.09 hours 1compartment NA NA Human Human -DTXSID8051544 Css NA 0.4965 mg/L 3compartmentss NA 50% Human Human -DTXSID8051544 Css NA 3.566 mg/L 3compartmentss NA 95% Human Human -DTXSID8051544 Css NA 0.4989 mg/L PBTK NA 50% Human Human -DTXSID8051544 Css NA 2.462 mg/L PBTK NA 95% Human Human -DTXSID8051544 Clint NA 0.3856 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051544 Fup NA 0.7671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051544 Vd NA 1.962 L/kg 1compartment NA NA Rat Human -DTXSID8051544 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8051544 TK.Half.Life NA 4.329 hours 1compartment NA NA Rat Human -DTXSID8051544 Css NA 0.1613 mg/L 3compartmentss NA 50% Rat Human -DTXSID8051544 Css NA 1.205 mg/L 3compartmentss NA 95% Rat Human -DTXSID8051544 Css NA 0.1597 mg/L PBTK NA 50% Rat Human -DTXSID8051544 Css NA 0.7628 mg/L PBTK NA 95% Rat Human +DTXSID8049418 TK.Half.Life NA 0.5074 hours 1compartment NA NA Rat Human +DTXSID8049418 Css NA 0.001 mg/L 3compartmentss NA 50% Rat Human +DTXSID8049418 Css NA 0.01423 mg/L 3compartmentss NA 95% Rat Human +DTXSID8049418 Css NA 0.0008409 mg/L PBTK NA 50% Rat Human +DTXSID8049418 Css NA 0.009639 mg/L PBTK NA 95% Rat Human +DTXSID8051540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8051540 Fup 0.0736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8051540 Vd NA 3.058 L/kg 1compartment NA NA Human Human +DTXSID8051540 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID8051540 TK.Half.Life NA 44.15 hours 1compartment NA NA Human Human +DTXSID8051540 Css NA 1.682 mg/L 3compartmentss NA 50% Human Human +DTXSID8051540 Css NA 10.73 mg/L 3compartmentss NA 95% Human Human +DTXSID8051540 Css NA 1.174 mg/L PBTK NA 50% Human Human +DTXSID8051540 Css NA 7.172 mg/L PBTK NA 95% Human Human +DTXSID8051540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8051540 Fup 0.0736 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8051540 Vd NA 2.293 L/kg 1compartment NA NA Rat Human +DTXSID8051540 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8051540 TK.Half.Life NA 6.73 hours 1compartment NA NA Rat Human +DTXSID8051540 Css NA 0.2162 mg/L 3compartmentss NA 50% Rat Human +DTXSID8051540 Css NA 1.187 mg/L 3compartmentss NA 95% Rat Human +DTXSID8051540 Css NA 0.1493 mg/L PBTK NA 50% Rat Human +DTXSID8051540 Css NA 0.7966 mg/L PBTK NA 95% Rat Human DTXSID8051629 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8051629 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051629 Vd NA 0.7546 L/kg 1compartment NA NA Human Human +DTXSID8051629 Vd NA 0.774 L/kg 1compartment NA NA Human Human DTXSID8051629 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8051629 TK.Half.Life NA 4.888 hours 1compartment NA NA Human Human -DTXSID8051629 Css NA 0.8402 mg/L 3compartmentss NA 50% Human Human -DTXSID8051629 Css NA 5.53 mg/L 3compartmentss NA 95% Human Human -DTXSID8051629 Css NA 0.7001 mg/L PBTK NA 50% Human Human -DTXSID8051629 Css NA 3.55 mg/L PBTK NA 95% Human Human +DTXSID8051629 TK.Half.Life NA 5.016 hours 1compartment NA NA Human Human +DTXSID8051629 Css NA 0.7068 mg/L 3compartmentss NA 50% Human Human +DTXSID8051629 Css NA 5.104 mg/L 3compartmentss NA 95% Human Human +DTXSID8051629 Css NA 0.5898 mg/L PBTK NA 50% Human Human +DTXSID8051629 Css NA 3.289 mg/L PBTK NA 95% Human Human DTXSID8051629 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8051629 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051629 Vd NA 0.7838 L/kg 1compartment NA NA Rat Human +DTXSID8051629 Vd NA 0.8005 L/kg 1compartment NA NA Rat Human DTXSID8051629 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8051629 TK.Half.Life NA 1.729 hours 1compartment NA NA Rat Human -DTXSID8051629 Css NA 0.2117 mg/L 3compartmentss NA 50% Rat Human -DTXSID8051629 Css NA 1.324 mg/L 3compartmentss NA 95% Rat Human -DTXSID8051629 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID8051629 Css NA 0.7933 mg/L PBTK NA 95% Rat Human -DTXSID8051704 Clint NA 6.617 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051704 Fup NA 0.7674 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051704 Vd NA 0.5587 L/kg 1compartment NA NA Human Human -DTXSID8051704 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8051704 TK.Half.Life NA 0.4395 hours 1compartment NA NA Human Human -DTXSID8051704 Css NA 0.02327 mg/L 3compartmentss NA 50% Human Human -DTXSID8051704 Css NA 0.2254 mg/L 3compartmentss NA 95% Human Human -DTXSID8051704 Css NA 0.01792 mg/L PBTK NA 50% Human Human -DTXSID8051704 Css NA 0.1512 mg/L PBTK NA 95% Human Human -DTXSID8051704 Clint NA 6.617 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051704 Fup NA 0.7674 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051704 Vd NA 0.6095 L/kg 1compartment NA NA Rat Human -DTXSID8051704 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8051704 TK.Half.Life NA 0.2264 hours 1compartment NA NA Rat Human -DTXSID8051704 Css NA 0.01205 mg/L 3compartmentss NA 50% Rat Human -DTXSID8051704 Css NA 0.1077 mg/L 3compartmentss NA 95% Rat Human -DTXSID8051704 Css NA 0.009032 mg/L PBTK NA 50% Rat Human -DTXSID8051704 Css NA 0.06777 mg/L PBTK NA 95% Rat Human -DTXSID8051708 Clint NA 0.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051708 Fup NA 0.3171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051708 Vd NA 2.001 L/kg 1compartment NA NA Human Human -DTXSID8051708 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID8051708 TK.Half.Life NA 25.58 hours 1compartment NA NA Human Human -DTXSID8051708 Css NA 1.36 mg/L 3compartmentss NA 50% Human Human -DTXSID8051708 Css NA 5.472 mg/L 3compartmentss NA 95% Human Human -DTXSID8051708 Css NA 1.05 mg/L PBTK NA 50% Human Human -DTXSID8051708 Css NA 3.718 mg/L PBTK NA 95% Human Human -DTXSID8051708 Clint NA 0.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051708 Fup NA 0.3171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051708 Vd NA 1.574 L/kg 1compartment NA NA Rat Human -DTXSID8051708 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8051708 TK.Half.Life NA 6.985 hours 1compartment NA NA Rat Human -DTXSID8051708 Css NA 0.5466 mg/L 3compartmentss NA 50% Rat Human -DTXSID8051708 Css NA 1.706 mg/L 3compartmentss NA 95% Rat Human -DTXSID8051708 Css NA 0.4071 mg/L PBTK NA 50% Rat Human -DTXSID8051708 Css NA 1.08 mg/L PBTK NA 95% Rat Human -DTXSID8051754 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051754 Fup NA 0.4216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051754 Vd NA 1.934 L/kg 1compartment NA NA Human Human -DTXSID8051754 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID8051754 TK.Half.Life NA 45.9 hours 1compartment NA NA Human Human -DTXSID8051754 Css NA 2.458 mg/L 3compartmentss NA 50% Human Human -DTXSID8051754 Css NA 9.613 mg/L 3compartmentss NA 95% Human Human -DTXSID8051754 Css NA 1.99 mg/L PBTK NA 50% Human Human -DTXSID8051754 Css NA 6.487 mg/L PBTK NA 95% Human Human -DTXSID8051754 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051754 Fup NA 0.4216 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051754 Vd NA 1.552 L/kg 1compartment NA NA Rat Human -DTXSID8051754 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8051754 TK.Half.Life NA 9.178 hours 1compartment NA NA Rat Human -DTXSID8051754 Css NA 0.6593 mg/L 3compartmentss NA 50% Rat Human -DTXSID8051754 Css NA 2.154 mg/L 3compartmentss NA 95% Rat Human -DTXSID8051754 Css NA 0.5161 mg/L PBTK NA 50% Rat Human -DTXSID8051754 Css NA 1.361 mg/L PBTK NA 95% Rat Human -DTXSID8051914 Clint NA 137.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051914 Fup NA 0.0495 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8051914 Vd NA 2.217 L/kg 1compartment NA NA Human Human -DTXSID8051914 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8051914 TK.Half.Life NA 3.707 hours 1compartment NA NA Human Human -DTXSID8051914 Css NA 0.1278 mg/L 3compartmentss NA 50% Human Human -DTXSID8051914 Css NA 0.97 mg/L 3compartmentss NA 95% Human Human -DTXSID8051914 Css NA 0.08495 mg/L PBTK NA 50% Human Human -DTXSID8051914 Css NA 0.6213 mg/L PBTK NA 95% Human Human -DTXSID8051914 Clint NA 137.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051914 Fup NA 0.0495 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8051914 Vd NA 1.661 L/kg 1compartment NA NA Rat Human -DTXSID8051914 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8051914 TK.Half.Life NA 1.157 hours 1compartment NA NA Rat Human -DTXSID8051914 Css NA 0.07215 mg/L 3compartmentss NA 50% Rat Human -DTXSID8051914 Css NA 0.4549 mg/L 3compartmentss NA 95% Rat Human -DTXSID8051914 Css NA 0.04534 mg/L PBTK NA 50% Rat Human -DTXSID8051914 Css NA 0.2711 mg/L PBTK NA 95% Rat Human +DTXSID8051629 TK.Half.Life NA 1.766 hours 1compartment NA NA Rat Human +DTXSID8051629 Css NA 0.01281 mg/L 3compartmentss NA 50% Rat Human +DTXSID8051629 Css NA 0.1008 mg/L 3compartmentss NA 95% Rat Human +DTXSID8051629 Css NA 0.0104 mg/L PBTK NA 50% Rat Human +DTXSID8051629 Css NA 0.0666 mg/L PBTK NA 95% Rat Human +DTXSID8051708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8051708 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8051708 Vd NA 1.355 L/kg 1compartment NA NA Human Human +DTXSID8051708 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8051708 TK.Half.Life NA 3.125 hours 1compartment NA NA Human Human +DTXSID8051708 Css NA 0.2206 mg/L 3compartmentss NA 50% Human Human +DTXSID8051708 Css NA 1.731 mg/L 3compartmentss NA 95% Human Human +DTXSID8051708 Css NA 0.1486 mg/L PBTK NA 50% Human Human +DTXSID8051708 Css NA 1.086 mg/L PBTK NA 95% Human Human +DTXSID8051708 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8051708 Fup 0.13 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8051708 Vd NA 1.054 L/kg 1compartment NA NA Rat Human +DTXSID8051708 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8051708 TK.Half.Life NA 1.258 hours 1compartment NA NA Rat Human +DTXSID8051708 Css NA 0.0284 mg/L 3compartmentss NA 50% Rat Human +DTXSID8051708 Css NA 0.1721 mg/L 3compartmentss NA 95% Rat Human +DTXSID8051708 Css NA 0.01869 mg/L PBTK NA 50% Rat Human +DTXSID8051708 Css NA 0.1067 mg/L PBTK NA 95% Rat Human +DTXSID8051754 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8051754 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8051754 Vd NA 1.91 L/kg 1compartment NA NA Human Human +DTXSID8051754 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8051754 TK.Half.Life NA 2.368 hours 1compartment NA NA Human Human +DTXSID8051754 Css NA 0.06336 mg/L 3compartmentss NA 50% Human Human +DTXSID8051754 Css NA 0.4664 mg/L 3compartmentss NA 95% Human Human +DTXSID8051754 Css NA 0.05077 mg/L PBTK NA 50% Human Human +DTXSID8051754 Css NA 0.3333 mg/L PBTK NA 95% Human Human +DTXSID8051754 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8051754 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8051754 Vd NA 1.532 L/kg 1compartment NA NA Rat Human +DTXSID8051754 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8051754 TK.Half.Life NA 0.8633 hours 1compartment NA NA Rat Human +DTXSID8051754 Css NA 0.007791 mg/L 3compartmentss NA 50% Rat Human +DTXSID8051754 Css NA 0.04585 mg/L 3compartmentss NA 95% Rat Human +DTXSID8051754 Css NA 0.006285 mg/L PBTK NA 50% Rat Human +DTXSID8051754 Css NA 0.03361 mg/L PBTK NA 95% Rat Human +DTXSID8051914 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8051914 Fup 0.0219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8051914 Vd NA 2.416 L/kg 1compartment NA NA Human Human +DTXSID8051914 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8051914 TK.Half.Life NA 27.29 hours 1compartment NA NA Human Human +DTXSID8051914 Css NA 1.578 mg/L 3compartmentss NA 50% Human Human +DTXSID8051914 Css NA 12.11 mg/L 3compartmentss NA 95% Human Human +DTXSID8051914 Css NA 1.04 mg/L PBTK NA 50% Human Human +DTXSID8051914 Css NA 7.641 mg/L PBTK NA 95% Human Human +DTXSID8051914 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8051914 Fup 0.0219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8051914 Vd NA 1.802 L/kg 1compartment NA NA Rat Human +DTXSID8051914 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID8051914 TK.Half.Life NA 7.117 hours 1compartment NA NA Rat Human +DTXSID8051914 Css NA 0.2037 mg/L 3compartmentss NA 50% Rat Human +DTXSID8051914 Css NA 1.276 mg/L 3compartmentss NA 95% Rat Human +DTXSID8051914 Css NA 0.1314 mg/L PBTK NA 50% Rat Human +DTXSID8051914 Css NA 0.7931 mg/L PBTK NA 95% Rat Human DTXSID8052148 Clint 109.1 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID8052148 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID8052148 Clint 109.1 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID8052148 Fup 0 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID8052300 Clint NA 2.925 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8052300 Fup NA 0.8158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8052300 Vd NA 0.8144 L/kg 1compartment NA NA Human Human +DTXSID8052300 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052300 Fup 0.816 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052300 Vd NA 0.8002 L/kg 1compartment NA NA Human Human DTXSID8052300 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8052300 TK.Half.Life NA 1.437 hours 1compartment NA NA Human Human -DTXSID8052300 Css NA 0.1751 mg/L 3compartmentss NA 50% Human Human -DTXSID8052300 Css NA 1.268 mg/L 3compartmentss NA 95% Human Human -DTXSID8052300 Css NA 0.1418 mg/L PBTK NA 50% Human Human -DTXSID8052300 Css NA 0.8669 mg/L PBTK NA 95% Human Human -DTXSID8052300 Clint NA 2.925 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8052300 Fup NA 0.8158 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8052300 Vd NA 0.8466 L/kg 1compartment NA NA Rat Human +DTXSID8052300 TK.Half.Life NA 6.348 hours 1compartment NA NA Human Human +DTXSID8052300 Css NA 0.8281 mg/L 3compartmentss NA 50% Human Human +DTXSID8052300 Css NA 5.125 mg/L 3compartmentss NA 95% Human Human +DTXSID8052300 Css NA 0.6853 mg/L PBTK NA 50% Human Human +DTXSID8052300 Css NA 3.281 mg/L PBTK NA 95% Human Human +DTXSID8052300 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052300 Fup 0.816 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052300 Vd NA 0.8341 L/kg 1compartment NA NA Rat Human DTXSID8052300 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8052300 TK.Half.Life NA 0.7898 hours 1compartment NA NA Rat Human -DTXSID8052300 Css NA 0.07717 mg/L 3compartmentss NA 50% Rat Human -DTXSID8052300 Css NA 0.4958 mg/L 3compartmentss NA 95% Rat Human -DTXSID8052300 Css NA 0.06208 mg/L PBTK NA 50% Rat Human -DTXSID8052300 Css NA 0.3057 mg/L PBTK NA 95% Rat Human -DTXSID8052308 Clint NA 0.01775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8052308 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8052308 Vd NA 0.8069 L/kg 1compartment NA NA Human Human +DTXSID8052300 TK.Half.Life NA 2.254 hours 1compartment NA NA Rat Human +DTXSID8052300 Css NA 0.01554 mg/L 3compartmentss NA 50% Rat Human +DTXSID8052300 Css NA 0.1161 mg/L 3compartmentss NA 95% Rat Human +DTXSID8052300 Css NA 0.01236 mg/L PBTK NA 50% Rat Human +DTXSID8052300 Css NA 0.07661 mg/L PBTK NA 95% Rat Human +DTXSID8052308 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052308 Fup 0.808 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052308 Vd NA 0.709 L/kg 1compartment NA NA Human Human DTXSID8052308 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8052308 TK.Half.Life NA 5.082 hours 1compartment NA NA Human Human -DTXSID8052308 Css NA 0.7893 mg/L 3compartmentss NA 50% Human Human -DTXSID8052308 Css NA 5.519 mg/L 3compartmentss NA 95% Human Human -DTXSID8052308 Css NA 0.6713 mg/L PBTK NA 50% Human Human -DTXSID8052308 Css NA 3.571 mg/L PBTK NA 95% Human Human -DTXSID8052308 Clint NA 0.01775 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8052308 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8052308 Vd NA 0.8395 L/kg 1compartment NA NA Rat Human +DTXSID8052308 TK.Half.Life NA 5.682 hours 1compartment NA NA Human Human +DTXSID8052308 Css NA 0.847 mg/L 3compartmentss NA 50% Human Human +DTXSID8052308 Css NA 5.145 mg/L 3compartmentss NA 95% Human Human +DTXSID8052308 Css NA 0.6896 mg/L PBTK NA 50% Human Human +DTXSID8052308 Css NA 3.281 mg/L PBTK NA 95% Human Human +DTXSID8052308 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052308 Fup 0.808 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052308 Vd NA 0.7369 L/kg 1compartment NA NA Rat Human DTXSID8052308 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8052308 TK.Half.Life NA 1.826 hours 1compartment NA NA Rat Human -DTXSID8052308 Css NA 0.2044 mg/L 3compartmentss NA 50% Rat Human -DTXSID8052308 Css NA 1.314 mg/L 3compartmentss NA 95% Rat Human -DTXSID8052308 Css NA 0.1701 mg/L PBTK NA 50% Rat Human -DTXSID8052308 Css NA 0.7921 mg/L PBTK NA 95% Rat Human -DTXSID8052641 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8052641 Fup NA 0.2661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8052641 Vd NA 1.627 L/kg 1compartment NA NA Human Human -DTXSID8052641 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID8052641 TK.Half.Life NA 54.84 hours 1compartment NA NA Human Human -DTXSID8052641 Css NA 3.708 mg/L 3compartmentss NA 50% Human Human -DTXSID8052641 Css NA 13.37 mg/L 3compartmentss NA 95% Human Human -DTXSID8052641 Css NA 2.772 mg/L PBTK NA 50% Human Human -DTXSID8052641 Css NA 8.724 mg/L PBTK NA 95% Human Human -DTXSID8052641 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8052641 Fup NA 0.2661 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8052641 Vd NA 1.29 L/kg 1compartment NA NA Rat Human -DTXSID8052641 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8052641 TK.Half.Life NA 11.67 hours 1compartment NA NA Rat Human -DTXSID8052641 Css NA 1.013 mg/L 3compartmentss NA 50% Rat Human -DTXSID8052641 Css NA 3.039 mg/L 3compartmentss NA 95% Rat Human -DTXSID8052641 Css NA 0.725 mg/L PBTK NA 50% Rat Human -DTXSID8052641 Css NA 1.85 mg/L PBTK NA 95% Rat Human -DTXSID8052724 Clint NA 2.542 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8052724 Fup NA 0.052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8052724 Vd NA 0.2619 L/kg 1compartment NA NA Human Human +DTXSID8052308 TK.Half.Life NA 2.011 hours 1compartment NA NA Rat Human +DTXSID8052308 Css NA 0.01604 mg/L 3compartmentss NA 50% Rat Human +DTXSID8052308 Css NA 0.1206 mg/L 3compartmentss NA 95% Rat Human +DTXSID8052308 Css NA 0.01255 mg/L PBTK NA 50% Rat Human +DTXSID8052308 Css NA 0.07704 mg/L PBTK NA 95% Rat Human +DTXSID8052510 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052510 Fup 0.824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052510 Vd NA 0.8369 L/kg 1compartment NA NA Human Human +DTXSID8052510 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8052510 TK.Half.Life NA 0.6394 hours 1compartment NA NA Human Human +DTXSID8052510 Css NA 0.0203 mg/L 3compartmentss NA 50% Human Human +DTXSID8052510 Css NA 0.2377 mg/L 3compartmentss NA 95% Human Human +DTXSID8052510 Css NA 0.01677 mg/L PBTK NA 50% Human Human +DTXSID8052510 Css NA 0.1664 mg/L PBTK NA 95% Human Human +DTXSID8052510 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052510 Fup 0.824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052510 Vd NA 0.8503 L/kg 1compartment NA NA Rat Human +DTXSID8052510 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8052510 TK.Half.Life NA 0.3141 hours 1compartment NA NA Rat Human +DTXSID8052510 Css NA 0.0007022 mg/L 3compartmentss NA 50% Rat Human +DTXSID8052510 Css NA 0.009617 mg/L 3compartmentss NA 95% Rat Human +DTXSID8052510 Css NA 0.0005694 mg/L PBTK NA 50% Rat Human +DTXSID8052510 Css NA 0.006704 mg/L PBTK NA 95% Rat Human +DTXSID8052641 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052641 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052641 Vd NA 1.349 L/kg 1compartment NA NA Human Human +DTXSID8052641 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8052641 TK.Half.Life NA 5.83 hours 1compartment NA NA Human Human +DTXSID8052641 Css NA 0.4432 mg/L 3compartmentss NA 50% Human Human +DTXSID8052641 Css NA 2.532 mg/L 3compartmentss NA 95% Human Human +DTXSID8052641 Css NA 0.3113 mg/L PBTK NA 50% Human Human +DTXSID8052641 Css NA 1.67 mg/L PBTK NA 95% Human Human +DTXSID8052641 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052641 Fup 0.179 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052641 Vd NA 1.064 L/kg 1compartment NA NA Rat Human +DTXSID8052641 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8052641 TK.Half.Life NA 2.382 hours 1compartment NA NA Rat Human +DTXSID8052641 Css NA 0.05283 mg/L 3compartmentss NA 50% Rat Human +DTXSID8052641 Css NA 0.2197 mg/L 3compartmentss NA 95% Rat Human +DTXSID8052641 Css NA 0.03675 mg/L PBTK NA 50% Rat Human +DTXSID8052641 Css NA 0.1396 mg/L PBTK NA 95% Rat Human +DTXSID8052645 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052645 Fup 0.582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052645 Vd NA 0.4711 L/kg 1compartment NA NA Human Human +DTXSID8052645 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8052645 TK.Half.Life NA 5.243 hours 1compartment NA NA Human Human +DTXSID8052645 Css NA 1.342 mg/L 3compartmentss NA 50% Human Human +DTXSID8052645 Css NA 8.826 mg/L 3compartmentss NA 95% Human Human +DTXSID8052645 Css NA 0.9806 mg/L PBTK NA 50% Human Human +DTXSID8052645 Css NA 5.377 mg/L PBTK NA 95% Human Human +DTXSID8052645 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052645 Fup 0.582 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052645 Vd NA 0.4795 L/kg 1compartment NA NA Rat Human +DTXSID8052645 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8052645 TK.Half.Life NA 1.817 hours 1compartment NA NA Rat Human +DTXSID8052645 Css NA 0.08271 mg/L 3compartmentss NA 50% Rat Human +DTXSID8052645 Css NA 0.477 mg/L 3compartmentss NA 95% Rat Human +DTXSID8052645 Css NA 0.05964 mg/L PBTK NA 50% Rat Human +DTXSID8052645 Css NA 0.2831 mg/L PBTK NA 95% Rat Human +DTXSID8052699 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052699 Fup 0.64 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052699 Vd NA 0.772 L/kg 1compartment NA NA Human Human +DTXSID8052699 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8052699 TK.Half.Life NA 7.805 hours 1compartment NA NA Human Human +DTXSID8052699 Css NA 0.9254 mg/L 3compartmentss NA 50% Human Human +DTXSID8052699 Css NA 6.56 mg/L 3compartmentss NA 95% Human Human +DTXSID8052699 Css NA 0.7904 mg/L PBTK NA 50% Human Human +DTXSID8052699 Css NA 4.176 mg/L PBTK NA 95% Human Human +DTXSID8052699 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052699 Fup 0.64 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052699 Vd NA 0.7824 L/kg 1compartment NA NA Rat Human +DTXSID8052699 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8052699 TK.Half.Life NA 2.695 hours 1compartment NA NA Rat Human +DTXSID8052699 Css NA 0.01782 mg/L 3compartmentss NA 50% Rat Human +DTXSID8052699 Css NA 0.1542 mg/L 3compartmentss NA 95% Rat Human +DTXSID8052699 Css NA 0.0146 mg/L PBTK NA 50% Rat Human +DTXSID8052699 Css NA 0.1005 mg/L PBTK NA 95% Rat Human +DTXSID8052724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052724 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8052724 Vd NA 0.3938 L/kg 1compartment NA NA Human Human DTXSID8052724 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8052724 TK.Half.Life NA 6.365 hours 1compartment NA NA Human Human -DTXSID8052724 Css NA 4.201 mg/L 3compartmentss NA 50% Human Human -DTXSID8052724 Css NA 25.24 mg/L 3compartmentss NA 95% Human Human -DTXSID8052724 Css NA 2.519 mg/L PBTK NA 50% Human Human -DTXSID8052724 Css NA 14.82 mg/L PBTK NA 95% Human Human -DTXSID8052724 Clint NA 2.542 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8052724 Fup NA 0.052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8052724 Vd NA 0.2462 L/kg 1compartment NA NA Rat Human +DTXSID8052724 TK.Half.Life NA 1.852 hours 1compartment NA NA Human Human +DTXSID8052724 Css NA 0.6032 mg/L 3compartmentss NA 50% Human Human +DTXSID8052724 Css NA 4.057 mg/L 3compartmentss NA 95% Human Human +DTXSID8052724 Css NA 0.3805 mg/L PBTK NA 50% Human Human +DTXSID8052724 Css NA 2.48 mg/L PBTK NA 95% Human Human +DTXSID8052724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052724 Fup 0.143 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8052724 Vd NA 0.3672 L/kg 1compartment NA NA Rat Human DTXSID8052724 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8052724 TK.Half.Life NA 3.45 hours 1compartment NA NA Rat Human -DTXSID8052724 Css NA 2.057 mg/L 3compartmentss NA 50% Rat Human -DTXSID8052724 Css NA 9.583 mg/L 3compartmentss NA 95% Rat Human -DTXSID8052724 Css NA 1.149 mg/L PBTK NA 50% Rat Human -DTXSID8052724 Css NA 5.219 mg/L PBTK NA 95% Rat Human -DTXSID8057641 Clint NA 8.304 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057641 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057641 Vd NA 3.121 L/kg 1compartment NA NA Human Human -DTXSID8057641 Days.Css NA 39 Days PBTK NA NA Human Human -DTXSID8057641 TK.Half.Life NA 198.1 hours 1compartment NA NA Human Human -DTXSID8057641 Css NA 7.722 mg/L 3compartmentss NA 50% Human Human -DTXSID8057641 Css NA 49.88 mg/L 3compartmentss NA 95% Human Human -DTXSID8057641 Css NA 5.386 mg/L PBTK NA 50% Human Human -DTXSID8057641 Css NA 33.38 mg/L PBTK NA 95% Human Human -DTXSID8057641 Clint NA 8.304 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057641 Fup NA 0.0556 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057641 Vd NA 2.339 L/kg 1compartment NA NA Rat Human -DTXSID8057641 Days.Css NA 22 Days PBTK NA NA Rat Human -DTXSID8057641 TK.Half.Life NA 25.96 hours 1compartment NA NA Rat Human -DTXSID8057641 Css NA 4.355 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057641 Css NA 21.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057641 Css NA 2.896 mg/L PBTK NA 50% Rat Human -DTXSID8057641 Css NA 13.98 mg/L PBTK NA 95% Rat Human -DTXSID8057643 Clint NA 56.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057643 Fup NA 0.0516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057643 Vd NA 2.935 L/kg 1compartment NA NA Human Human +DTXSID8052724 TK.Half.Life NA 1.03 hours 1compartment NA NA Rat Human +DTXSID8052724 Css NA 0.07486 mg/L 3compartmentss NA 50% Rat Human +DTXSID8052724 Css NA 0.3667 mg/L 3compartmentss NA 95% Rat Human +DTXSID8052724 Css NA 0.04606 mg/L PBTK NA 50% Rat Human +DTXSID8052724 Css NA 0.2126 mg/L PBTK NA 95% Rat Human +DTXSID8057641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057641 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057641 Vd NA 3.113 L/kg 1compartment NA NA Human Human +DTXSID8057641 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID8057641 TK.Half.Life NA 89.5 hours 1compartment NA NA Human Human +DTXSID8057641 Css NA 3.423 mg/L 3compartmentss NA 50% Human Human +DTXSID8057641 Css NA 21.02 mg/L 3compartmentss NA 95% Human Human +DTXSID8057641 Css NA 2.386 mg/L PBTK NA 50% Human Human +DTXSID8057641 Css NA 14.19 mg/L PBTK NA 95% Human Human +DTXSID8057641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057641 Fup 0.0176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057641 Vd NA 2.332 L/kg 1compartment NA NA Rat Human +DTXSID8057641 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID8057641 TK.Half.Life NA 12.16 hours 1compartment NA NA Rat Human +DTXSID8057641 Css NA 0.4432 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057641 Css NA 2.28 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057641 Css NA 0.3036 mg/L PBTK NA 50% Rat Human +DTXSID8057641 Css NA 1.531 mg/L PBTK NA 95% Rat Human +DTXSID8057643 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057643 Fup 0.0767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057643 Vd NA 3.201 L/kg 1compartment NA NA Human Human DTXSID8057643 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057643 TK.Half.Life NA 6.261 hours 1compartment NA NA Human Human -DTXSID8057643 Css NA 0.1883 mg/L 3compartmentss NA 50% Human Human -DTXSID8057643 Css NA 1.293 mg/L 3compartmentss NA 95% Human Human -DTXSID8057643 Css NA 0.1368 mg/L PBTK NA 50% Human Human -DTXSID8057643 Css NA 0.879 mg/L PBTK NA 95% Human Human -DTXSID8057643 Clint NA 56.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057643 Fup NA 0.0516 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057643 Vd NA 2.341 L/kg 1compartment NA NA Rat Human +DTXSID8057643 TK.Half.Life NA 14.66 hours 1compartment NA NA Human Human +DTXSID8057643 Css NA 0.4664 mg/L 3compartmentss NA 50% Human Human +DTXSID8057643 Css NA 3.078 mg/L 3compartmentss NA 95% Human Human +DTXSID8057643 Css NA 0.34 mg/L PBTK NA 50% Human Human +DTXSID8057643 Css NA 2.159 mg/L PBTK NA 95% Human Human +DTXSID8057643 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057643 Fup 0.0767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057643 Vd NA 2.513 L/kg 1compartment NA NA Rat Human DTXSID8057643 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057643 TK.Half.Life NA 1.817 hours 1compartment NA NA Rat Human -DTXSID8057643 Css NA 0.1038 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057643 Css NA 0.6284 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057643 Css NA 0.07252 mg/L PBTK NA 50% Rat Human -DTXSID8057643 Css NA 0.4099 mg/L PBTK NA 95% Rat Human -DTXSID8057645 Clint NA 26.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057645 Fup NA 0.1835 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057645 Vd NA 0.3843 L/kg 1compartment NA NA Human Human -DTXSID8057645 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057645 TK.Half.Life NA 0.6194 hours 1compartment NA NA Human Human -DTXSID8057645 Css NA 0.1073 mg/L 3compartmentss NA 50% Human Human -DTXSID8057645 Css NA 0.7635 mg/L 3compartmentss NA 95% Human Human -DTXSID8057645 Css NA 0.06997 mg/L PBTK NA 50% Human Human -DTXSID8057645 Css NA 0.4788 mg/L PBTK NA 95% Human Human -DTXSID8057645 Clint NA 26.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057645 Fup NA 0.1835 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057645 Vd NA 0.3816 L/kg 1compartment NA NA Rat Human +DTXSID8057643 TK.Half.Life NA 3.09 hours 1compartment NA NA Rat Human +DTXSID8057643 Css NA 0.05955 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057643 Css NA 0.3356 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057643 Css NA 0.04374 mg/L PBTK NA 50% Rat Human +DTXSID8057643 Css NA 0.2313 mg/L PBTK NA 95% Rat Human +DTXSID8057645 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057645 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057645 Vd NA 0.5877 L/kg 1compartment NA NA Human Human +DTXSID8057645 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID8057645 TK.Half.Life NA 11.81 hours 1compartment NA NA Human Human +DTXSID8057645 Css NA 2.216 mg/L 3compartmentss NA 50% Human Human +DTXSID8057645 Css NA 9.099 mg/L 3compartmentss NA 95% Human Human +DTXSID8057645 Css NA 1.607 mg/L PBTK NA 50% Human Human +DTXSID8057645 Css NA 5.739 mg/L PBTK NA 95% Human Human +DTXSID8057645 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057645 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057645 Vd NA 0.5689 L/kg 1compartment NA NA Rat Human DTXSID8057645 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057645 TK.Half.Life NA 0.3375 hours 1compartment NA NA Rat Human -DTXSID8057645 Css NA 0.05948 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057645 Css NA 0.3101 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057645 Css NA 0.03653 mg/L PBTK NA 50% Rat Human -DTXSID8057645 Css NA 0.185 mg/L PBTK NA 95% Rat Human -DTXSID8057647 Clint NA 10.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057647 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057647 Vd NA 2.817 L/kg 1compartment NA NA Human Human -DTXSID8057647 Days.Css NA 24 Days PBTK NA NA Human Human -DTXSID8057647 TK.Half.Life NA 133.3 hours 1compartment NA NA Human Human -DTXSID8057647 Css NA 6.604 mg/L 3compartmentss NA 50% Human Human -DTXSID8057647 Css NA 42.8 mg/L 3compartmentss NA 95% Human Human -DTXSID8057647 Css NA 4.464 mg/L PBTK NA 50% Human Human -DTXSID8057647 Css NA 27.78 mg/L PBTK NA 95% Human Human -DTXSID8057647 Clint NA 10.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057647 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057647 Vd NA 2.104 L/kg 1compartment NA NA Rat Human -DTXSID8057647 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID8057647 TK.Half.Life NA 24.92 hours 1compartment NA NA Rat Human -DTXSID8057647 Css NA 3.708 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057647 Css NA 20.03 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057647 Css NA 2.367 mg/L PBTK NA 50% Rat Human -DTXSID8057647 Css NA 12.57 mg/L PBTK NA 95% Rat Human -DTXSID8057649 Clint NA 40.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057649 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057649 Vd NA 2.326 L/kg 1compartment NA NA Human Human -DTXSID8057649 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8057649 TK.Half.Life NA 24.48 hours 1compartment NA NA Human Human -DTXSID8057649 Css NA 1.539 mg/L 3compartmentss NA 50% Human Human -DTXSID8057649 Css NA 12.4 mg/L 3compartmentss NA 95% Human Human -DTXSID8057649 Css NA 0.9972 mg/L PBTK NA 50% Human Human -DTXSID8057649 Css NA 7.727 mg/L PBTK NA 95% Human Human -DTXSID8057649 Clint NA 40.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057649 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057649 Vd NA 1.728 L/kg 1compartment NA NA Rat Human -DTXSID8057649 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID8057649 TK.Half.Life NA 6.723 hours 1compartment NA NA Rat Human -DTXSID8057649 Css NA 0.8761 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057649 Css NA 5.569 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057649 Css NA 0.5362 mg/L PBTK NA 50% Rat Human -DTXSID8057649 Css NA 3.301 mg/L PBTK NA 95% Rat Human -DTXSID8057691 Clint NA 0.1128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057691 Fup NA 0.115 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057691 Vd NA 0.2349 L/kg 1compartment NA NA Human Human -DTXSID8057691 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID8057691 TK.Half.Life NA 11.08 hours 1compartment NA NA Human Human -DTXSID8057691 Css NA 7.238 mg/L 3compartmentss NA 50% Human Human -DTXSID8057691 Css NA 33.26 mg/L 3compartmentss NA 95% Human Human -DTXSID8057691 Css NA 4.41 mg/L PBTK NA 50% Human Human -DTXSID8057691 Css NA 19.51 mg/L PBTK NA 95% Human Human -DTXSID8057691 Clint NA 0.1128 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057691 Fup NA 0.115 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057691 Vd NA 0.237 L/kg 1compartment NA NA Rat Human +DTXSID8057645 TK.Half.Life NA 3.866 hours 1compartment NA NA Rat Human +DTXSID8057645 Css NA 0.144 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057645 Css NA 0.4907 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057645 Css NA 0.1018 mg/L PBTK NA 50% Rat Human +DTXSID8057645 Css NA 0.2995 mg/L PBTK NA 95% Rat Human +DTXSID8057647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057647 Fup 0.00597 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057647 Vd NA 3.011 L/kg 1compartment NA NA Human Human +DTXSID8057647 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID8057647 TK.Half.Life NA 83.89 hours 1compartment NA NA Human Human +DTXSID8057647 Css NA 3.482 mg/L 3compartmentss NA 50% Human Human +DTXSID8057647 Css NA 22.99 mg/L 3compartmentss NA 95% Human Human +DTXSID8057647 Css NA 2.372 mg/L PBTK NA 50% Human Human +DTXSID8057647 Css NA 15.26 mg/L PBTK NA 95% Human Human +DTXSID8057647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057647 Fup 0.00597 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057647 Vd NA 2.254 L/kg 1compartment NA NA Rat Human +DTXSID8057647 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID8057647 TK.Half.Life NA 12.98 hours 1compartment NA NA Rat Human +DTXSID8057647 Css NA 0.4526 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057647 Css NA 2.426 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057647 Css NA 0.3067 mg/L PBTK NA 50% Rat Human +DTXSID8057647 Css NA 1.576 mg/L PBTK NA 95% Rat Human +DTXSID8057649 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057649 Fup 0.0148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057649 Vd NA 2.491 L/kg 1compartment NA NA Human Human +DTXSID8057649 Days.Css NA 21 Days PBTK NA NA Human Human +DTXSID8057649 TK.Half.Life NA 117.9 hours 1compartment NA NA Human Human +DTXSID8057649 Css NA 6.88 mg/L 3compartmentss NA 50% Human Human +DTXSID8057649 Css NA 47.79 mg/L 3compartmentss NA 95% Human Human +DTXSID8057649 Css NA 4.506 mg/L PBTK NA 50% Human Human +DTXSID8057649 Css NA 29.89 mg/L PBTK NA 95% Human Human +DTXSID8057649 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057649 Fup 0.0148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057649 Vd NA 1.857 L/kg 1compartment NA NA Rat Human +DTXSID8057649 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID8057649 TK.Half.Life NA 28.1 hours 1compartment NA NA Rat Human +DTXSID8057649 Css NA 0.8768 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057649 Css NA 4.653 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057649 Css NA 0.5696 mg/L PBTK NA 50% Rat Human +DTXSID8057649 Css NA 2.872 mg/L PBTK NA 95% Rat Human +DTXSID8057691 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057691 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057691 Vd NA 0.3345 L/kg 1compartment NA NA Human Human +DTXSID8057691 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8057691 TK.Half.Life NA 6.89 hours 1compartment NA NA Human Human +DTXSID8057691 Css NA 2.452 mg/L 3compartmentss NA 50% Human Human +DTXSID8057691 Css NA 9.371 mg/L 3compartmentss NA 95% Human Human +DTXSID8057691 Css NA 1.638 mg/L PBTK NA 50% Human Human +DTXSID8057691 Css NA 5.736 mg/L PBTK NA 95% Human Human +DTXSID8057691 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057691 Fup 0.314 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057691 Vd NA 0.342 L/kg 1compartment NA NA Rat Human DTXSID8057691 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057691 TK.Half.Life NA 4.156 hours 1compartment NA NA Rat Human -DTXSID8057691 Css NA 2.288 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057691 Css NA 8.916 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057691 Css NA 1.302 mg/L PBTK NA 50% Rat Human -DTXSID8057691 Css NA 4.89 mg/L PBTK NA 95% Rat Human -DTXSID8057693 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057693 Fup NA 0.0074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057693 Vd NA 0.1791 L/kg 1compartment NA NA Human Human -DTXSID8057693 Days.Css NA 36 Days PBTK NA NA Human Human -DTXSID8057693 TK.Half.Life NA 156.6 hours 1compartment NA NA Human Human -DTXSID8057693 Css NA 152 mg/L 3compartmentss NA 50% Human Human -DTXSID8057693 Css NA 922.2 mg/L 3compartmentss NA 95% Human Human -DTXSID8057693 Css NA 88.42 mg/L PBTK NA 50% Human Human -DTXSID8057693 Css NA 533.2 mg/L PBTK NA 95% Human Human -DTXSID8057693 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057693 Fup NA 0.0074 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057693 Vd NA 0.1749 L/kg 1compartment NA NA Rat Human -DTXSID8057693 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID8057693 TK.Half.Life NA 52.12 hours 1compartment NA NA Rat Human -DTXSID8057693 Css NA 43.02 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057693 Css NA 224.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057693 Css NA 23.4 mg/L PBTK NA 50% Rat Human -DTXSID8057693 Css NA 121.6 mg/L PBTK NA 95% Rat Human -DTXSID8057695 Clint NA 40.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057695 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057695 Vd NA 0.2355 L/kg 1compartment NA NA Human Human -DTXSID8057695 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057695 TK.Half.Life NA 1.926 hours 1compartment NA NA Human Human -DTXSID8057695 Css NA 1.398 mg/L 3compartmentss NA 50% Human Human -DTXSID8057695 Css NA 14.62 mg/L 3compartmentss NA 95% Human Human -DTXSID8057695 Css NA 0.8179 mg/L PBTK NA 50% Human Human -DTXSID8057695 Css NA 8.434 mg/L PBTK NA 95% Human Human -DTXSID8057695 Clint NA 40.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057695 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057695 Vd NA 0.2109 L/kg 1compartment NA NA Rat Human -DTXSID8057695 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057695 TK.Half.Life NA 1.138 hours 1compartment NA NA Rat Human -DTXSID8057695 Css NA 0.8024 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057695 Css NA 6.718 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057695 Css NA 0.4386 mg/L PBTK NA 50% Rat Human -DTXSID8057695 Css NA 3.633 mg/L PBTK NA 95% Rat Human -DTXSID8057697 Clint NA 475.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057697 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057697 Vd NA 3.047 L/kg 1compartment NA NA Human Human -DTXSID8057697 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057697 TK.Half.Life NA 6.033 hours 1compartment NA NA Human Human -DTXSID8057697 Css NA 0.1497 mg/L 3compartmentss NA 50% Human Human -DTXSID8057697 Css NA 0.9785 mg/L 3compartmentss NA 95% Human Human -DTXSID8057697 Css NA 0.1034 mg/L PBTK NA 50% Human Human -DTXSID8057697 Css NA 0.6447 mg/L PBTK NA 95% Human Human -DTXSID8057697 Clint NA 475.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057697 Fup NA 0.0107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057697 Vd NA 2.281 L/kg 1compartment NA NA Rat Human -DTXSID8057697 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057697 TK.Half.Life NA 1.328 hours 1compartment NA NA Rat Human -DTXSID8057697 Css NA 0.08498 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057697 Css NA 0.4499 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057697 Css NA 0.05585 mg/L PBTK NA 50% Rat Human -DTXSID8057697 Css NA 0.2876 mg/L PBTK NA 95% Rat Human -DTXSID8057699 Clint NA 26.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057699 Fup NA 0.1512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057699 Vd NA 2.245 L/kg 1compartment NA NA Human Human +DTXSID8057691 TK.Half.Life NA 2.401 hours 1compartment NA NA Rat Human +DTXSID8057691 Css NA 0.1576 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057691 Css NA 0.5208 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057691 Css NA 0.1032 mg/L PBTK NA 50% Rat Human +DTXSID8057691 Css NA 0.3079 mg/L PBTK NA 95% Rat Human +DTXSID8057693 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057693 Fup 0.0778 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057693 Vd NA 0.3129 L/kg 1compartment NA NA Human Human +DTXSID8057693 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8057693 TK.Half.Life NA 0.9692 hours 1compartment NA NA Human Human +DTXSID8057693 Css NA 0.3796 mg/L 3compartmentss NA 50% Human Human +DTXSID8057693 Css NA 2.925 mg/L 3compartmentss NA 95% Human Human +DTXSID8057693 Css NA 0.2356 mg/L PBTK NA 50% Human Human +DTXSID8057693 Css NA 1.747 mg/L PBTK NA 95% Human Human +DTXSID8057693 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057693 Fup 0.0778 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057693 Vd NA 0.3015 L/kg 1compartment NA NA Rat Human +DTXSID8057693 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8057693 TK.Half.Life NA 0.5677 hours 1compartment NA NA Rat Human +DTXSID8057693 Css NA 0.04956 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057693 Css NA 0.3011 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057693 Css NA 0.02981 mg/L PBTK NA 50% Rat Human +DTXSID8057693 Css NA 0.1734 mg/L PBTK NA 95% Rat Human +DTXSID8057695 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057695 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057695 Vd NA 3.259 L/kg 1compartment NA NA Human Human +DTXSID8057695 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID8057695 TK.Half.Life NA 51.65 hours 1compartment NA NA Human Human +DTXSID8057695 Css NA 1.488 mg/L 3compartmentss NA 50% Human Human +DTXSID8057695 Css NA 9.177 mg/L 3compartmentss NA 95% Human Human +DTXSID8057695 Css NA 1.104 mg/L PBTK NA 50% Human Human +DTXSID8057695 Css NA 6.403 mg/L PBTK NA 95% Human Human +DTXSID8057695 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057695 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057695 Vd NA 2.538 L/kg 1compartment NA NA Rat Human +DTXSID8057695 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID8057695 TK.Half.Life NA 8.494 hours 1compartment NA NA Rat Human +DTXSID8057695 Css NA 0.07397 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057695 Css NA 0.4468 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057695 Css NA 0.05384 mg/L PBTK NA 50% Rat Human +DTXSID8057695 Css NA 0.3112 mg/L PBTK NA 95% Rat Human +DTXSID8057697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057697 Fup 0.00876 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057697 Vd NA 2.079 L/kg 1compartment NA NA Human Human +DTXSID8057697 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID8057697 TK.Half.Life NA 35.49 hours 1compartment NA NA Human Human +DTXSID8057697 Css NA 2.634 mg/L 3compartmentss NA 50% Human Human +DTXSID8057697 Css NA 21.97 mg/L 3compartmentss NA 95% Human Human +DTXSID8057697 Css NA 1.688 mg/L PBTK NA 50% Human Human +DTXSID8057697 Css NA 13.41 mg/L PBTK NA 95% Human Human +DTXSID8057697 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057697 Fup 0.00876 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057697 Vd NA 1.54 L/kg 1compartment NA NA Rat Human +DTXSID8057697 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID8057697 TK.Half.Life NA 10.95 hours 1compartment NA NA Rat Human +DTXSID8057697 Css NA 0.342 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057697 Css NA 2.28 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057697 Css NA 0.2136 mg/L PBTK NA 50% Rat Human +DTXSID8057697 Css NA 1.377 mg/L PBTK NA 95% Rat Human +DTXSID8057699 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057699 Fup 0.25 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057699 Vd NA 3.116 L/kg 1compartment NA NA Human Human DTXSID8057699 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057699 TK.Half.Life NA 3.259 hours 1compartment NA NA Human Human -DTXSID8057699 Css NA 0.09948 mg/L 3compartmentss NA 50% Human Human -DTXSID8057699 Css NA 0.8819 mg/L 3compartmentss NA 95% Human Human -DTXSID8057699 Css NA 0.08504 mg/L PBTK NA 50% Human Human -DTXSID8057699 Css NA 0.6477 mg/L PBTK NA 95% Human Human -DTXSID8057699 Clint NA 26.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057699 Fup NA 0.1512 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057699 Vd NA 2.222 L/kg 1compartment NA NA Rat Human +DTXSID8057699 TK.Half.Life NA 7.909 hours 1compartment NA NA Human Human +DTXSID8057699 Css NA 0.1675 mg/L 3compartmentss NA 50% Human Human +DTXSID8057699 Css NA 1.224 mg/L 3compartmentss NA 95% Human Human +DTXSID8057699 Css NA 0.1776 mg/L PBTK NA 50% Human Human +DTXSID8057699 Css NA 1.044 mg/L PBTK NA 95% Human Human +DTXSID8057699 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057699 Fup 0.25 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057699 Vd NA 3.111 L/kg 1compartment NA NA Rat Human DTXSID8057699 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057699 TK.Half.Life NA 1.818 hours 1compartment NA NA Rat Human -DTXSID8057699 Css NA 0.05456 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057699 Css NA 0.3786 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057699 Css NA 0.04488 mg/L PBTK NA 50% Rat Human -DTXSID8057699 Css NA 0.2585 mg/L PBTK NA 95% Rat Human -DTXSID8057720 Clint NA 170.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057720 Fup NA 0.1799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057720 Vd NA 1.091 L/kg 1compartment NA NA Human Human +DTXSID8057699 TK.Half.Life NA 4.53 hours 1compartment NA NA Rat Human +DTXSID8057699 Css NA 0.01959 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057699 Css NA 0.1047 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057699 Css NA 0.02124 mg/L PBTK NA 50% Rat Human +DTXSID8057699 Css NA 0.08639 mg/L PBTK NA 95% Rat Human +DTXSID8057720 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057720 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057720 Vd NA 1.34 L/kg 1compartment NA NA Human Human DTXSID8057720 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057720 TK.Half.Life NA 1.014 hours 1compartment NA NA Human Human -DTXSID8057720 Css NA 0.01724 mg/L 3compartmentss NA 50% Human Human -DTXSID8057720 Css NA 0.13 mg/L 3compartmentss NA 95% Human Human -DTXSID8057720 Css NA 0.01199 mg/L PBTK NA 50% Human Human -DTXSID8057720 Css NA 0.08499 mg/L PBTK NA 95% Human Human -DTXSID8057720 Clint NA 170.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057720 Fup NA 0.1799 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057720 Vd NA 0.884 L/kg 1compartment NA NA Rat Human +DTXSID8057720 TK.Half.Life NA 2.513 hours 1compartment NA NA Human Human +DTXSID8057720 Css NA 0.1374 mg/L 3compartmentss NA 50% Human Human +DTXSID8057720 Css NA 0.9909 mg/L 3compartmentss NA 95% Human Human +DTXSID8057720 Css NA 0.09603 mg/L PBTK NA 50% Human Human +DTXSID8057720 Css NA 0.6673 mg/L PBTK NA 95% Human Human +DTXSID8057720 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057720 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057720 Vd NA 1.06 L/kg 1compartment NA NA Rat Human DTXSID8057720 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057720 TK.Half.Life NA 0.3788 hours 1compartment NA NA Rat Human -DTXSID8057720 Css NA 0.009583 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057720 Css NA 0.05955 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057720 Css NA 0.006346 mg/L PBTK NA 50% Rat Human -DTXSID8057720 Css NA 0.03772 mg/L PBTK NA 95% Rat Human -DTXSID8057722 Clint NA 263.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057722 Fup NA 0.4713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057722 Vd NA 1.887 L/kg 1compartment NA NA Human Human +DTXSID8057720 TK.Half.Life NA 1.019 hours 1compartment NA NA Rat Human +DTXSID8057720 Css NA 0.0176 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057720 Css NA 0.09327 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057720 Css NA 0.0122 mg/L PBTK NA 50% Rat Human +DTXSID8057720 Css NA 0.06044 mg/L PBTK NA 95% Rat Human +DTXSID8057722 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057722 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057722 Vd NA 1.282 L/kg 1compartment NA NA Human Human DTXSID8057722 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057722 TK.Half.Life NA 1.173 hours 1compartment NA NA Human Human -DTXSID8057722 Css NA 0.003467 mg/L 3compartmentss NA 50% Human Human -DTXSID8057722 Css NA 0.03237 mg/L 3compartmentss NA 95% Human Human -DTXSID8057722 Css NA 0.00312 mg/L PBTK NA 50% Human Human -DTXSID8057722 Css NA 0.02411 mg/L PBTK NA 95% Human Human -DTXSID8057722 Clint NA 263.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057722 Fup NA 0.4713 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057722 Vd NA 1.75 L/kg 1compartment NA NA Rat Human +DTXSID8057722 TK.Half.Life NA 3.588 hours 1compartment NA NA Human Human +DTXSID8057722 Css NA 0.2422 mg/L 3compartmentss NA 50% Human Human +DTXSID8057722 Css NA 1.46 mg/L 3compartmentss NA 95% Human Human +DTXSID8057722 Css NA 0.186 mg/L PBTK NA 50% Human Human +DTXSID8057722 Css NA 1.012 mg/L PBTK NA 95% Human Human +DTXSID8057722 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057722 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057722 Vd NA 1.187 L/kg 1compartment NA NA Rat Human DTXSID8057722 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057722 TK.Half.Life NA 0.48 hours 1compartment NA NA Rat Human -DTXSID8057722 Css NA 0.001859 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057722 Css NA 0.01483 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057722 Css NA 0.00164 mg/L PBTK NA 50% Rat Human -DTXSID8057722 Css NA 0.01105 mg/L PBTK NA 95% Rat Human -DTXSID8057724 Clint NA 24.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057724 Fup NA 0.2246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057724 Vd NA 1.888 L/kg 1compartment NA NA Human Human +DTXSID8057722 TK.Half.Life NA 1.866 hours 1compartment NA NA Rat Human +DTXSID8057722 Css NA 0.02806 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057722 Css NA 0.1352 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057722 Css NA 0.02171 mg/L PBTK NA 50% Rat Human +DTXSID8057722 Css NA 0.08944 mg/L PBTK NA 95% Rat Human +DTXSID8057724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057724 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057724 Vd NA 3.017 L/kg 1compartment NA NA Human Human DTXSID8057724 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057724 TK.Half.Life NA 2.296 hours 1compartment NA NA Human Human -DTXSID8057724 Css NA 0.06297 mg/L 3compartmentss NA 50% Human Human -DTXSID8057724 Css NA 0.4762 mg/L 3compartmentss NA 95% Human Human -DTXSID8057724 Css NA 0.05714 mg/L PBTK NA 50% Human Human -DTXSID8057724 Css NA 0.3803 mg/L PBTK NA 95% Human Human -DTXSID8057724 Clint NA 24.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057724 Fup NA 0.2246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057724 Vd NA 1.872 L/kg 1compartment NA NA Rat Human +DTXSID8057724 TK.Half.Life NA 4.741 hours 1compartment NA NA Human Human +DTXSID8057724 Css NA 0.08766 mg/L 3compartmentss NA 50% Human Human +DTXSID8057724 Css NA 0.7086 mg/L 3compartmentss NA 95% Human Human +DTXSID8057724 Css NA 0.105 mg/L PBTK NA 50% Human Human +DTXSID8057724 Css NA 0.6377 mg/L PBTK NA 95% Human Human +DTXSID8057724 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057724 Fup 0.434 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057724 Vd NA 3.02 L/kg 1compartment NA NA Rat Human DTXSID8057724 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057724 TK.Half.Life NA 1.272 hours 1compartment NA NA Rat Human -DTXSID8057724 Css NA 0.0333 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057724 Css NA 0.2003 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057724 Css NA 0.02968 mg/L PBTK NA 50% Rat Human -DTXSID8057724 Css NA 0.1471 mg/L PBTK NA 95% Rat Human -DTXSID8057726 Clint NA 41.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057726 Fup NA 0.6929 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057726 Vd NA 1.113 L/kg 1compartment NA NA Human Human +DTXSID8057724 TK.Half.Life NA 2.759 hours 1compartment NA NA Rat Human +DTXSID8057724 Css NA 0.009736 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057724 Css NA 0.06825 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057724 Css NA 0.01216 mg/L PBTK NA 50% Rat Human +DTXSID8057724 Css NA 0.05761 mg/L PBTK NA 95% Rat Human +DTXSID8057726 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057726 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057726 Vd NA 1.06 L/kg 1compartment NA NA Human Human DTXSID8057726 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057726 TK.Half.Life NA 0.79 hours 1compartment NA NA Human Human -DTXSID8057726 Css NA 0.01652 mg/L 3compartmentss NA 50% Human Human -DTXSID8057726 Css NA 0.1737 mg/L 3compartmentss NA 95% Human Human -DTXSID8057726 Css NA 0.01416 mg/L PBTK NA 50% Human Human -DTXSID8057726 Css NA 0.127 mg/L PBTK NA 95% Human Human -DTXSID8057726 Clint NA 41.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057726 Fup NA 0.6929 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057726 Vd NA 1.041 L/kg 1compartment NA NA Rat Human +DTXSID8057726 TK.Half.Life NA 1.537 hours 1compartment NA NA Human Human +DTXSID8057726 Css NA 0.1052 mg/L 3compartmentss NA 50% Human Human +DTXSID8057726 Css NA 0.9187 mg/L 3compartmentss NA 95% Human Human +DTXSID8057726 Css NA 0.0883 mg/L PBTK NA 50% Human Human +DTXSID8057726 Css NA 0.6276 mg/L PBTK NA 95% Human Human +DTXSID8057726 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057726 Fup 0.626 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057726 Vd NA 0.9868 L/kg 1compartment NA NA Rat Human DTXSID8057726 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057726 TK.Half.Life NA 0.3448 hours 1compartment NA NA Rat Human -DTXSID8057726 Css NA 0.008402 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057726 Css NA 0.0859 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057726 Css NA 0.007104 mg/L PBTK NA 50% Rat Human -DTXSID8057726 Css NA 0.0569 mg/L PBTK NA 95% Rat Human +DTXSID8057726 TK.Half.Life NA 0.7581 hours 1compartment NA NA Rat Human +DTXSID8057726 Css NA 0.01165 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057726 Css NA 0.09432 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057726 Css NA 0.009972 mg/L PBTK NA 50% Rat Human +DTXSID8057726 Css NA 0.0601 mg/L PBTK NA 95% Rat Human DTXSID8057728 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID8057728 Fup NA 0.267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057728 Vd NA 1.859 L/kg 1compartment NA NA Human Human -DTXSID8057728 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID8057728 TK.Half.Life NA 60.96 hours 1compartment NA NA Human Human -DTXSID8057728 Css NA 3.44 mg/L 3compartmentss NA 50% Human Human -DTXSID8057728 Css NA 12.74 mg/L 3compartmentss NA 95% Human Human -DTXSID8057728 Css NA 2.699 mg/L PBTK NA 50% Human Human -DTXSID8057728 Css NA 8.551 mg/L PBTK NA 95% Human Human +DTXSID8057728 Vd NA 0.3486 L/kg 1compartment NA NA Human Human +DTXSID8057728 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8057728 TK.Half.Life NA 8.446 hours 1compartment NA NA Human Human +DTXSID8057728 Css NA 2.485 mg/L 3compartmentss NA 50% Human Human +DTXSID8057728 Css NA 9.584 mg/L 3compartmentss NA 95% Human Human +DTXSID8057728 Css NA 1.664 mg/L PBTK NA 50% Human Human +DTXSID8057728 Css NA 5.849 mg/L PBTK NA 95% Human Human DTXSID8057728 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID8057728 Fup NA 0.267 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057728 Vd NA 1.558 L/kg 1compartment NA NA Rat Human -DTXSID8057728 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8057728 TK.Half.Life NA 13.95 hours 1compartment NA NA Rat Human -DTXSID8057728 Css NA 0.938 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057728 Css NA 2.908 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057728 Css NA 0.708 mg/L PBTK NA 50% Rat Human -DTXSID8057728 Css NA 1.814 mg/L PBTK NA 95% Rat Human -DTXSID8057770 Clint NA 8.727 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057770 Fup NA 0.26 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057770 Vd NA 2.166 L/kg 1compartment NA NA Human Human +DTXSID8057728 Vd NA 0.3679 L/kg 1compartment NA NA Rat Human +DTXSID8057728 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8057728 TK.Half.Life NA 3.037 hours 1compartment NA NA Rat Human +DTXSID8057728 Css NA 0.04633 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057728 Css NA 0.26 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057728 Css NA 0.02938 mg/L PBTK NA 50% Rat Human +DTXSID8057728 Css NA 0.158 mg/L PBTK NA 95% Rat Human +DTXSID8057770 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057770 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057770 Vd NA 1.893 L/kg 1compartment NA NA Human Human DTXSID8057770 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057770 TK.Half.Life NA 5.208 hours 1compartment NA NA Human Human -DTXSID8057770 Css NA 0.1905 mg/L 3compartmentss NA 50% Human Human -DTXSID8057770 Css NA 1.249 mg/L 3compartmentss NA 95% Human Human -DTXSID8057770 Css NA 0.1618 mg/L PBTK NA 50% Human Human -DTXSID8057770 Css NA 0.9312 mg/L PBTK NA 95% Human Human -DTXSID8057770 Clint NA 8.727 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057770 Fup NA 0.26 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057770 Vd NA 1.969 L/kg 1compartment NA NA Rat Human +DTXSID8057770 TK.Half.Life NA 1.938 hours 1compartment NA NA Human Human +DTXSID8057770 Css NA 0.04237 mg/L 3compartmentss NA 50% Human Human +DTXSID8057770 Css NA 0.3711 mg/L 3compartmentss NA 95% Human Human +DTXSID8057770 Css NA 0.03803 mg/L PBTK NA 50% Human Human +DTXSID8057770 Css NA 0.2816 mg/L PBTK NA 95% Human Human +DTXSID8057770 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057770 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057770 Vd NA 1.833 L/kg 1compartment NA NA Rat Human DTXSID8057770 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057770 TK.Half.Life NA 2.48 hours 1compartment NA NA Rat Human -DTXSID8057770 Css NA 0.0984 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057770 Css NA 0.4716 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057770 Css NA 0.08141 mg/L PBTK NA 50% Rat Human -DTXSID8057770 Css NA 0.3358 mg/L PBTK NA 95% Rat Human -DTXSID8057772 Clint NA 0.7305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057772 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057772 Vd NA 0.2979 L/kg 1compartment NA NA Human Human -DTXSID8057772 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID8057772 TK.Half.Life NA 35.42 hours 1compartment NA NA Human Human -DTXSID8057772 Css NA 19.99 mg/L 3compartmentss NA 50% Human Human -DTXSID8057772 Css NA 131.7 mg/L 3compartmentss NA 95% Human Human -DTXSID8057772 Css NA 12.11 mg/L PBTK NA 50% Human Human -DTXSID8057772 Css NA 77.05 mg/L PBTK NA 95% Human Human -DTXSID8057772 Clint NA 0.7305 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057772 Fup NA 0.0246 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057772 Vd NA 0.2882 L/kg 1compartment NA NA Rat Human -DTXSID8057772 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID8057772 TK.Half.Life NA 16.26 hours 1compartment NA NA Rat Human -DTXSID8057772 Css NA 8.035 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057772 Css NA 45.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057772 Css NA 4.554 mg/L PBTK NA 50% Rat Human -DTXSID8057772 Css NA 24.79 mg/L PBTK NA 95% Rat Human -DTXSID8057774 Clint NA 26.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057774 Fup NA 0.594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057774 Vd NA 0.4798 L/kg 1compartment NA NA Human Human -DTXSID8057774 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057774 TK.Half.Life NA 0.4449 hours 1compartment NA NA Human Human -DTXSID8057774 Css NA 0.03308 mg/L 3compartmentss NA 50% Human Human -DTXSID8057774 Css NA 0.3132 mg/L 3compartmentss NA 95% Human Human -DTXSID8057774 Css NA 0.02402 mg/L PBTK NA 50% Human Human -DTXSID8057774 Css NA 0.2066 mg/L PBTK NA 95% Human Human -DTXSID8057774 Clint NA 26.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057774 Fup NA 0.594 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057774 Vd NA 0.4898 L/kg 1compartment NA NA Rat Human -DTXSID8057774 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057774 TK.Half.Life NA 0.2196 hours 1compartment NA NA Rat Human -DTXSID8057774 Css NA 0.01721 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057774 Css NA 0.1482 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057774 Css NA 0.01192 mg/L PBTK NA 50% Rat Human -DTXSID8057774 Css NA 0.08878 mg/L PBTK NA 95% Rat Human -DTXSID8057776 Clint NA 0.8516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057776 Fup NA 0.5367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057776 Vd NA 0.4671 L/kg 1compartment NA NA Human Human +DTXSID8057770 TK.Half.Life NA 0.9743 hours 1compartment NA NA Rat Human +DTXSID8057770 Css NA 0.005182 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057770 Css NA 0.03523 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057770 Css NA 0.00473 mg/L PBTK NA 50% Rat Human +DTXSID8057770 Css NA 0.02723 mg/L PBTK NA 95% Rat Human +DTXSID8057772 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057772 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057772 Vd NA 0.3537 L/kg 1compartment NA NA Human Human +DTXSID8057772 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8057772 TK.Half.Life NA 5.658 hours 1compartment NA NA Human Human +DTXSID8057772 Css NA 2.694 mg/L 3compartmentss NA 50% Human Human +DTXSID8057772 Css NA 21.9 mg/L 3compartmentss NA 95% Human Human +DTXSID8057772 Css NA 1.671 mg/L PBTK NA 50% Human Human +DTXSID8057772 Css NA 13.02 mg/L PBTK NA 95% Human Human +DTXSID8057772 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057772 Fup 0.0372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057772 Vd NA 0.343 L/kg 1compartment NA NA Rat Human +DTXSID8057772 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8057772 TK.Half.Life NA 3.452 hours 1compartment NA NA Rat Human +DTXSID8057772 Css NA 0.3402 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057772 Css NA 2 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057772 Css NA 0.205 mg/L PBTK NA 50% Rat Human +DTXSID8057772 Css NA 1.154 mg/L PBTK NA 95% Rat Human +DTXSID8057776 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057776 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057776 Vd NA 0.6822 L/kg 1compartment NA NA Human Human DTXSID8057776 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057776 TK.Half.Life NA 2.458 hours 1compartment NA NA Human Human -DTXSID8057776 Css NA 0.6073 mg/L 3compartmentss NA 50% Human Human -DTXSID8057776 Css NA 3.643 mg/L 3compartmentss NA 95% Human Human -DTXSID8057776 Css NA 0.4422 mg/L PBTK NA 50% Human Human -DTXSID8057776 Css NA 2.277 mg/L PBTK NA 95% Human Human -DTXSID8057776 Clint NA 0.8516 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057776 Fup NA 0.5367 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057776 Vd NA 0.4784 L/kg 1compartment NA NA Rat Human +DTXSID8057776 TK.Half.Life NA 8.069 hours 1compartment NA NA Human Human +DTXSID8057776 Css NA 1.302 mg/L 3compartmentss NA 50% Human Human +DTXSID8057776 Css NA 8.143 mg/L 3compartmentss NA 95% Human Human +DTXSID8057776 Css NA 1.023 mg/L PBTK NA 50% Human Human +DTXSID8057776 Css NA 5.104 mg/L PBTK NA 95% Human Human +DTXSID8057776 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057776 Fup 0.55 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057776 Vd NA 0.6848 L/kg 1compartment NA NA Rat Human DTXSID8057776 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057776 TK.Half.Life NA 1.193 hours 1compartment NA NA Rat Human -DTXSID8057776 Css NA 0.2328 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057776 Css NA 1.255 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057776 Css NA 0.1617 mg/L PBTK NA 50% Rat Human -DTXSID8057776 Css NA 0.7216 mg/L PBTK NA 95% Rat Human -DTXSID8057778 Clint NA 4.105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057778 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057778 Vd NA 1.984 L/kg 1compartment NA NA Human Human -DTXSID8057778 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID8057778 TK.Half.Life NA 112.8 hours 1compartment NA NA Human Human -DTXSID8057778 Css NA 9.189 mg/L 3compartmentss NA 50% Human Human -DTXSID8057778 Css NA 64.22 mg/L 3compartmentss NA 95% Human Human -DTXSID8057778 Css NA 5.884 mg/L PBTK NA 50% Human Human -DTXSID8057778 Css NA 39.13 mg/L PBTK NA 95% Human Human -DTXSID8057778 Clint NA 4.105 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057778 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057778 Vd NA 1.471 L/kg 1compartment NA NA Rat Human -DTXSID8057778 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID8057778 TK.Half.Life NA 34.38 hours 1compartment NA NA Rat Human -DTXSID8057778 Css NA 4.87 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057778 Css NA 26.14 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057778 Css NA 2.942 mg/L PBTK NA 50% Rat Human -DTXSID8057778 Css NA 14.89 mg/L PBTK NA 95% Rat Human -DTXSID8057801 Clint NA 4.504 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057801 Fup NA 0.1861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057801 Vd NA 0.3139 L/kg 1compartment NA NA Human Human +DTXSID8057776 TK.Half.Life NA 2.748 hours 1compartment NA NA Rat Human +DTXSID8057776 Css NA 0.0803 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057776 Css NA 0.4742 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057776 Css NA 0.06274 mg/L PBTK NA 50% Rat Human +DTXSID8057776 Css NA 0.2881 mg/L PBTK NA 95% Rat Human +DTXSID8057778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057778 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057778 Vd NA 0.3617 L/kg 1compartment NA NA Human Human +DTXSID8057778 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8057778 TK.Half.Life NA 0.6353 hours 1compartment NA NA Human Human +DTXSID8057778 Css NA 0.1209 mg/L 3compartmentss NA 50% Human Human +DTXSID8057778 Css NA 0.8513 mg/L 3compartmentss NA 95% Human Human +DTXSID8057778 Css NA 0.07788 mg/L PBTK NA 50% Human Human +DTXSID8057778 Css NA 0.5291 mg/L PBTK NA 95% Human Human +DTXSID8057778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057778 Fup 0.187 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057778 Vd NA 0.3497 L/kg 1compartment NA NA Rat Human +DTXSID8057778 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8057778 TK.Half.Life NA 0.3409 hours 1compartment NA NA Rat Human +DTXSID8057778 Css NA 0.01552 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057778 Css NA 0.08282 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057778 Css NA 0.009752 mg/L PBTK NA 50% Rat Human +DTXSID8057778 Css NA 0.05026 mg/L PBTK NA 95% Rat Human +DTXSID8057801 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057801 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057801 Vd NA 0.462 L/kg 1compartment NA NA Human Human DTXSID8057801 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057801 TK.Half.Life NA 1.471 hours 1compartment NA NA Human Human -DTXSID8057801 Css NA 0.5498 mg/L 3compartmentss NA 50% Human Human -DTXSID8057801 Css NA 3.15 mg/L 3compartmentss NA 95% Human Human -DTXSID8057801 Css NA 0.3548 mg/L PBTK NA 50% Human Human -DTXSID8057801 Css NA 1.913 mg/L PBTK NA 95% Human Human -DTXSID8057801 Clint NA 4.504 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057801 Fup NA 0.1861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057801 Vd NA 0.3171 L/kg 1compartment NA NA Rat Human +DTXSID8057801 TK.Half.Life NA 7.625 hours 1compartment NA NA Human Human +DTXSID8057801 Css NA 0.9956 mg/L 3compartmentss NA 50% Human Human +DTXSID8057801 Css NA 4.566 mg/L 3compartmentss NA 95% Human Human +DTXSID8057801 Css NA 0.725 mg/L PBTK NA 50% Human Human +DTXSID8057801 Css NA 2.91 mg/L PBTK NA 95% Human Human +DTXSID8057801 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057801 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057801 Vd NA 0.4682 L/kg 1compartment NA NA Rat Human DTXSID8057801 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057801 TK.Half.Life NA 0.8698 hours 1compartment NA NA Rat Human -DTXSID8057801 Css NA 0.2786 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057801 Css NA 1.119 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057801 Css NA 0.169 mg/L PBTK NA 50% Rat Human -DTXSID8057801 Css NA 0.643 mg/L PBTK NA 95% Rat Human -DTXSID8057803 Clint NA 28.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057803 Fup NA 0.3394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057803 Vd NA 3.48 L/kg 1compartment NA NA Human Human +DTXSID8057801 TK.Half.Life NA 2.635 hours 1compartment NA NA Rat Human +DTXSID8057801 Css NA 0.005394 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057801 Css NA 0.02587 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057801 Css NA 0.003764 mg/L PBTK NA 50% Rat Human +DTXSID8057801 Css NA 0.01566 mg/L PBTK NA 95% Rat Human +DTXSID8057803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057803 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057803 Vd NA 3.221 L/kg 1compartment NA NA Human Human DTXSID8057803 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057803 TK.Half.Life NA 2.442 hours 1compartment NA NA Human Human -DTXSID8057803 Css NA 0.02132 mg/L 3compartmentss NA 50% Human Human -DTXSID8057803 Css NA 0.1983 mg/L 3compartmentss NA 95% Human Human -DTXSID8057803 Css NA 0.02788 mg/L PBTK NA 50% Human Human -DTXSID8057803 Css NA 0.1914 mg/L PBTK NA 95% Human Human -DTXSID8057803 Clint NA 28.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057803 Fup NA 0.3394 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057803 Vd NA 3.477 L/kg 1compartment NA NA Rat Human +DTXSID8057803 TK.Half.Life NA 2.831 hours 1compartment NA NA Human Human +DTXSID8057803 Css NA 0.03143 mg/L 3compartmentss NA 50% Human Human +DTXSID8057803 Css NA 0.2917 mg/L 3compartmentss NA 95% Human Human +DTXSID8057803 Css NA 0.03849 mg/L PBTK NA 50% Human Human +DTXSID8057803 Css NA 0.2691 mg/L PBTK NA 95% Human Human +DTXSID8057803 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057803 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057803 Vd NA 3.214 L/kg 1compartment NA NA Rat Human DTXSID8057803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057803 TK.Half.Life NA 1.313 hours 1compartment NA NA Rat Human -DTXSID8057803 Css NA 0.01103 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057803 Css NA 0.08467 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057803 Css NA 0.01442 mg/L PBTK NA 50% Rat Human -DTXSID8057803 Css NA 0.08229 mg/L PBTK NA 95% Rat Human -DTXSID8057805 Clint NA 1.933 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057805 Fup NA 0.0606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057805 Vd NA 0.7182 L/kg 1compartment NA NA Human Human -DTXSID8057805 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8057805 TK.Half.Life NA 18.32 hours 1compartment NA NA Human Human -DTXSID8057805 Css NA 3.967 mg/L 3compartmentss NA 50% Human Human -DTXSID8057805 Css NA 22.85 mg/L 3compartmentss NA 95% Human Human -DTXSID8057805 Css NA 2.734 mg/L PBTK NA 50% Human Human -DTXSID8057805 Css NA 14.16 mg/L PBTK NA 95% Human Human -DTXSID8057805 Clint NA 1.933 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057805 Fup NA 0.0606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057805 Vd NA 0.6501 L/kg 1compartment NA NA Rat Human +DTXSID8057803 TK.Half.Life NA 1.577 hours 1compartment NA NA Rat Human +DTXSID8057803 Css NA 0.00385 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057803 Css NA 0.02778 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057803 Css NA 0.00489 mg/L PBTK NA 50% Rat Human +DTXSID8057803 Css NA 0.02597 mg/L PBTK NA 95% Rat Human +DTXSID8057805 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057805 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057805 Vd NA 0.2531 L/kg 1compartment NA NA Human Human +DTXSID8057805 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8057805 TK.Half.Life NA 0.7405 hours 1compartment NA NA Human Human +DTXSID8057805 Css NA 0.1773 mg/L 3compartmentss NA 50% Human Human +DTXSID8057805 Css NA 1.558 mg/L 3compartmentss NA 95% Human Human +DTXSID8057805 Css NA 0.109 mg/L PBTK NA 50% Human Human +DTXSID8057805 Css NA 0.9137 mg/L PBTK NA 95% Human Human +DTXSID8057805 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057805 Fup 0.12 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057805 Vd NA 0.2628 L/kg 1compartment NA NA Rat Human DTXSID8057805 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057805 TK.Half.Life NA 9.087 hours 1compartment NA NA Rat Human -DTXSID8057805 Css NA 1.795 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057805 Css NA 8.163 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057805 Css NA 1.18 mg/L PBTK NA 50% Rat Human -DTXSID8057805 Css NA 4.681 mg/L PBTK NA 95% Rat Human -DTXSID8057807 Clint NA 4.687 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057807 Fup NA 0.7304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057807 Vd NA 0.6976 L/kg 1compartment NA NA Human Human +DTXSID8057805 TK.Half.Life NA 0.4587 hours 1compartment NA NA Rat Human +DTXSID8057805 Css NA 0.001858 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057805 Css NA 0.01411 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057805 Css NA 0.001075 mg/L PBTK NA 50% Rat Human +DTXSID8057805 Css NA 0.007907 mg/L PBTK NA 95% Rat Human +DTXSID8057807 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057807 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057807 Vd NA 0.6308 L/kg 1compartment NA NA Human Human DTXSID8057807 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057807 TK.Half.Life NA 1.05 hours 1compartment NA NA Human Human -DTXSID8057807 Css NA 0.13 mg/L 3compartmentss NA 50% Human Human -DTXSID8057807 Css NA 1.052 mg/L 3compartmentss NA 95% Human Human -DTXSID8057807 Css NA 0.1036 mg/L PBTK NA 50% Human Human -DTXSID8057807 Css NA 0.697 mg/L PBTK NA 95% Human Human -DTXSID8057807 Clint NA 4.687 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057807 Fup NA 0.7304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057807 Vd NA 0.721 L/kg 1compartment NA NA Rat Human +DTXSID8057807 TK.Half.Life NA 6.633 hours 1compartment NA NA Human Human +DTXSID8057807 Css NA 1.044 mg/L 3compartmentss NA 50% Human Human +DTXSID8057807 Css NA 7.12 mg/L 3compartmentss NA 95% Human Human +DTXSID8057807 Css NA 0.824 mg/L PBTK NA 50% Human Human +DTXSID8057807 Css NA 4.46 mg/L PBTK NA 95% Human Human +DTXSID8057807 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057807 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057807 Vd NA 0.6517 L/kg 1compartment NA NA Rat Human DTXSID8057807 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057807 TK.Half.Life NA 0.5796 hours 1compartment NA NA Rat Human -DTXSID8057807 Css NA 0.06 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057807 Css NA 0.4286 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057807 Css NA 0.04711 mg/L PBTK NA 50% Rat Human -DTXSID8057807 Css NA 0.2599 mg/L PBTK NA 95% Rat Human -DTXSID8057809 Clint NA 1.129 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057809 Fup NA 0.0673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057809 Vd NA 0.2293 L/kg 1compartment NA NA Human Human +DTXSID8057807 TK.Half.Life NA 2.333 hours 1compartment NA NA Rat Human +DTXSID8057807 Css NA 0.02732 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057807 Css NA 0.2185 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057807 Css NA 0.02101 mg/L PBTK NA 50% Rat Human +DTXSID8057807 Css NA 0.137 mg/L PBTK NA 95% Rat Human +DTXSID8057809 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057809 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057809 Vd NA 0.283 L/kg 1compartment NA NA Human Human DTXSID8057809 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057809 TK.Half.Life NA 7.738 hours 1compartment NA NA Human Human -DTXSID8057809 Css NA 5.539 mg/L 3compartmentss NA 50% Human Human -DTXSID8057809 Css NA 24.93 mg/L 3compartmentss NA 95% Human Human -DTXSID8057809 Css NA 3.342 mg/L PBTK NA 50% Human Human -DTXSID8057809 Css NA 14.63 mg/L PBTK NA 95% Human Human -DTXSID8057809 Clint NA 1.129 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057809 Fup NA 0.0673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057809 Vd NA 0.2279 L/kg 1compartment NA NA Rat Human +DTXSID8057809 TK.Half.Life NA 1.435 hours 1compartment NA NA Human Human +DTXSID8057809 Css NA 0.6768 mg/L 3compartmentss NA 50% Human Human +DTXSID8057809 Css NA 4.851 mg/L 3compartmentss NA 95% Human Human +DTXSID8057809 Css NA 0.4222 mg/L PBTK NA 50% Human Human +DTXSID8057809 Css NA 2.855 mg/L PBTK NA 95% Human Human +DTXSID8057809 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057809 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057809 Vd NA 0.2825 L/kg 1compartment NA NA Rat Human DTXSID8057809 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057809 TK.Half.Life NA 3.923 hours 1compartment NA NA Rat Human -DTXSID8057809 Css NA 2.34 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057809 Css NA 8.263 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057809 Css NA 1.318 mg/L PBTK NA 50% Rat Human -DTXSID8057809 Css NA 4.525 mg/L PBTK NA 95% Rat Human -DTXSID8057851 Clint NA 57.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057851 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057851 Vd NA 1.59 L/kg 1compartment NA NA Human Human +DTXSID8057809 TK.Half.Life NA 0.8619 hours 1compartment NA NA Rat Human +DTXSID8057809 Css NA 0.08308 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057809 Css NA 0.4309 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057809 Css NA 0.05022 mg/L PBTK NA 50% Rat Human +DTXSID8057809 Css NA 0.2482 mg/L PBTK NA 95% Rat Human +DTXSID8057851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057851 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057851 Vd NA 3.592 L/kg 1compartment NA NA Human Human DTXSID8057851 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057851 TK.Half.Life NA 2.307 hours 1compartment NA NA Human Human -DTXSID8057851 Css NA 0.1081 mg/L 3compartmentss NA 50% Human Human -DTXSID8057851 Css NA 0.9774 mg/L 3compartmentss NA 95% Human Human -DTXSID8057851 Css NA 0.07941 mg/L PBTK NA 50% Human Human -DTXSID8057851 Css NA 0.6522 mg/L PBTK NA 95% Human Human -DTXSID8057851 Clint NA 57.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057851 Fup NA 0.0772 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057851 Vd NA 1.557 L/kg 1compartment NA NA Rat Human +DTXSID8057851 TK.Half.Life NA 4.245 hours 1compartment NA NA Human Human +DTXSID8057851 Css NA 0.0554 mg/L 3compartmentss NA 50% Human Human +DTXSID8057851 Css NA 0.43 mg/L 3compartmentss NA 95% Human Human +DTXSID8057851 Css NA 0.06 mg/L PBTK NA 50% Human Human +DTXSID8057851 Css NA 0.3969 mg/L PBTK NA 95% Human Human +DTXSID8057851 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057851 Fup 0.211 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057851 Vd NA 3.538 L/kg 1compartment NA NA Rat Human DTXSID8057851 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057851 TK.Half.Life NA 1.255 hours 1compartment NA NA Rat Human -DTXSID8057851 Css NA 0.06106 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057851 Css NA 0.4494 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057851 Css NA 0.04243 mg/L PBTK NA 50% Rat Human -DTXSID8057851 Css NA 0.2761 mg/L PBTK NA 95% Rat Human -DTXSID8057853 Clint NA 1.154 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057853 Fup NA 0.0413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057853 Vd NA 0.299 L/kg 1compartment NA NA Human Human -DTXSID8057853 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID8057853 TK.Half.Life NA 16.22 hours 1compartment NA NA Human Human -DTXSID8057853 Css NA 9.353 mg/L 3compartmentss NA 50% Human Human -DTXSID8057853 Css NA 60.14 mg/L 3compartmentss NA 95% Human Human -DTXSID8057853 Css NA 5.71 mg/L PBTK NA 50% Human Human -DTXSID8057853 Css NA 34.95 mg/L PBTK NA 95% Human Human -DTXSID8057853 Clint NA 1.154 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057853 Fup NA 0.0413 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057853 Vd NA 0.2926 L/kg 1compartment NA NA Rat Human +DTXSID8057851 TK.Half.Life NA 2.227 hours 1compartment NA NA Rat Human +DTXSID8057851 Css NA 0.006634 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057851 Css NA 0.04125 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057851 Css NA 0.007512 mg/L PBTK NA 50% Rat Human +DTXSID8057851 Css NA 0.03909 mg/L PBTK NA 95% Rat Human +DTXSID8057853 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057853 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057853 Vd NA 0.4769 L/kg 1compartment NA NA Human Human +DTXSID8057853 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8057853 TK.Half.Life NA 1.115 hours 1compartment NA NA Human Human +DTXSID8057853 Css NA 0.235 mg/L 3compartmentss NA 50% Human Human +DTXSID8057853 Css NA 1.987 mg/L 3compartmentss NA 95% Human Human +DTXSID8057853 Css NA 0.1557 mg/L PBTK NA 50% Human Human +DTXSID8057853 Css NA 1.236 mg/L PBTK NA 95% Human Human +DTXSID8057853 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057853 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057853 Vd NA 0.47 L/kg 1compartment NA NA Rat Human DTXSID8057853 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057853 TK.Half.Life NA 8.136 hours 1compartment NA NA Rat Human -DTXSID8057853 Css NA 4.042 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057853 Css NA 21.15 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057853 Css NA 2.3 mg/L PBTK NA 50% Rat Human -DTXSID8057853 Css NA 11.55 mg/L PBTK NA 95% Rat Human -DTXSID8057855 Clint NA 5.905 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057855 Fup NA 0.8204 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057855 Vd NA 2.144 L/kg 1compartment NA NA Human Human +DTXSID8057853 TK.Half.Life NA 0.6502 hours 1compartment NA NA Rat Human +DTXSID8057853 Css NA 0.03038 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057853 Css NA 0.1957 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057853 Css NA 0.01967 mg/L PBTK NA 50% Rat Human +DTXSID8057853 Css NA 0.1179 mg/L PBTK NA 95% Rat Human +DTXSID8057855 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057855 Fup 0.631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057855 Vd NA 1.808 L/kg 1compartment NA NA Human Human DTXSID8057855 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057855 TK.Half.Life NA 2.471 hours 1compartment NA NA Human Human -DTXSID8057855 Css NA 0.08056 mg/L 3compartmentss NA 50% Human Human -DTXSID8057855 Css NA 0.671 mg/L 3compartmentss NA 95% Human Human -DTXSID8057855 Css NA 0.0806 mg/L PBTK NA 50% Human Human -DTXSID8057855 Css NA 0.5329 mg/L PBTK NA 95% Human Human -DTXSID8057855 Clint NA 5.905 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057855 Fup NA 0.8204 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057855 Vd NA 2.118 L/kg 1compartment NA NA Rat Human +DTXSID8057855 TK.Half.Life NA 2.487 hours 1compartment NA NA Human Human +DTXSID8057855 Css NA 0.09168 mg/L 3compartmentss NA 50% Human Human +DTXSID8057855 Css NA 0.938 mg/L 3compartmentss NA 95% Human Human +DTXSID8057855 Css NA 0.08732 mg/L PBTK NA 50% Human Human +DTXSID8057855 Css NA 0.6712 mg/L PBTK NA 95% Human Human +DTXSID8057855 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057855 Fup 0.631 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057855 Vd NA 1.779 L/kg 1compartment NA NA Rat Human DTXSID8057855 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057855 TK.Half.Life NA 1.291 hours 1compartment NA NA Rat Human -DTXSID8057855 Css NA 0.03758 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057855 Css NA 0.3003 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057855 Css NA 0.03795 mg/L PBTK NA 50% Rat Human -DTXSID8057855 Css NA 0.2042 mg/L PBTK NA 95% Rat Human -DTXSID8057857 Clint NA 86.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057857 Fup NA 0.052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID8057857 Vd NA 2.735 L/kg 1compartment NA NA Human Human -DTXSID8057857 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID8057857 TK.Half.Life NA 7.706 hours 1compartment NA NA Human Human -DTXSID8057857 Css NA 0.2785 mg/L 3compartmentss NA 50% Human Human -DTXSID8057857 Css NA 1.803 mg/L 3compartmentss NA 95% Human Human -DTXSID8057857 Css NA 0.1889 mg/L PBTK NA 50% Human Human -DTXSID8057857 Css NA 1.183 mg/L PBTK NA 95% Human Human -DTXSID8057857 Clint NA 86.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057857 Fup NA 0.052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID8057857 Vd NA 2.05 L/kg 1compartment NA NA Rat Human -DTXSID8057857 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID8057857 TK.Half.Life NA 1.851 hours 1compartment NA NA Rat Human -DTXSID8057857 Css NA 0.1572 mg/L 3compartmentss NA 50% Rat Human -DTXSID8057857 Css NA 0.8648 mg/L 3compartmentss NA 95% Rat Human -DTXSID8057857 Css NA 0.1021 mg/L PBTK NA 50% Rat Human -DTXSID8057857 Css NA 0.5488 mg/L PBTK NA 95% Rat Human -DTXSID901017944 Clint NA 0.03394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID901017944 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID901017944 Vd NA 0.2303 L/kg 1compartment NA NA Human Human -DTXSID901017944 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID901017944 TK.Half.Life NA 58.84 hours 1compartment NA NA Human Human -DTXSID901017944 Css NA 43.3 mg/L 3compartmentss NA 50% Human Human -DTXSID901017944 Css NA 262 mg/L 3compartmentss NA 95% Human Human -DTXSID901017944 Css NA 25.47 mg/L PBTK NA 50% Human Human -DTXSID901017944 Css NA 152.1 mg/L PBTK NA 95% Human Human -DTXSID901017944 Clint NA 0.03394 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID901017944 Fup NA 0.024 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID901017944 Vd NA 0.2133 L/kg 1compartment NA NA Rat Human -DTXSID901017944 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID901017944 TK.Half.Life NA 19.07 hours 1compartment NA NA Rat Human -DTXSID901017944 Css NA 12.75 mg/L 3compartmentss NA 50% Rat Human -DTXSID901017944 Css NA 72.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID901017944 Css NA 7.017 mg/L PBTK NA 50% Rat Human -DTXSID901017944 Css NA 39.34 mg/L PBTK NA 95% Rat Human +DTXSID8057855 TK.Half.Life NA 1.32 hours 1compartment NA NA Rat Human +DTXSID8057855 Css NA 0.01006 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057855 Css NA 0.09236 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057855 Css NA 0.00981 mg/L PBTK NA 50% Rat Human +DTXSID8057855 Css NA 0.06169 mg/L PBTK NA 95% Rat Human +DTXSID8057857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057857 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8057857 Vd NA 2.733 L/kg 1compartment NA NA Human Human +DTXSID8057857 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID8057857 TK.Half.Life NA 44.09 hours 1compartment NA NA Human Human +DTXSID8057857 Css NA 2.166 mg/L 3compartmentss NA 50% Human Human +DTXSID8057857 Css NA 15.7 mg/L 3compartmentss NA 95% Human Human +DTXSID8057857 Css NA 1.45 mg/L PBTK NA 50% Human Human +DTXSID8057857 Css NA 10.04 mg/L PBTK NA 95% Human Human +DTXSID8057857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057857 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8057857 Vd NA 2.042 L/kg 1compartment NA NA Rat Human +DTXSID8057857 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8057857 TK.Half.Life NA 9.131 hours 1compartment NA NA Rat Human +DTXSID8057857 Css NA 0.2786 mg/L 3compartmentss NA 50% Rat Human +DTXSID8057857 Css NA 1.651 mg/L 3compartmentss NA 95% Rat Human +DTXSID8057857 Css NA 0.184 mg/L PBTK NA 50% Rat Human +DTXSID8057857 Css NA 1.076 mg/L PBTK NA 95% Rat Human +DTXSID8059766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8059766 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8059766 Vd NA 1.665 L/kg 1compartment NA NA Human Human +DTXSID8059766 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8059766 TK.Half.Life NA 11.65 hours 1compartment NA NA Human Human +DTXSID8059766 Css NA 1.014 mg/L 3compartmentss NA 50% Human Human +DTXSID8059766 Css NA 8.732 mg/L 3compartmentss NA 95% Human Human +DTXSID8059766 Css NA 0.6457 mg/L PBTK NA 50% Human Human +DTXSID8059766 Css NA 5.326 mg/L PBTK NA 95% Human Human +DTXSID8059766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8059766 Fup 0.0305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8059766 Vd NA 1.241 L/kg 1compartment NA NA Rat Human +DTXSID8059766 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8059766 TK.Half.Life NA 4.263 hours 1compartment NA NA Rat Human +DTXSID8059766 Css NA 0.132 mg/L 3compartmentss NA 50% Rat Human +DTXSID8059766 Css NA 0.9166 mg/L 3compartmentss NA 95% Rat Human +DTXSID8059766 Css NA 0.08188 mg/L PBTK NA 50% Rat Human +DTXSID8059766 Css NA 0.5364 mg/L PBTK NA 95% Rat Human +DTXSID8060539 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8060539 Fup 0.00998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8060539 Vd NA 2.798 L/kg 1compartment NA NA Human Human +DTXSID8060539 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID8060539 TK.Half.Life NA 57.33 hours 1compartment NA NA Human Human +DTXSID8060539 Css NA 2.718 mg/L 3compartmentss NA 50% Human Human +DTXSID8060539 Css NA 18.84 mg/L 3compartmentss NA 95% Human Human +DTXSID8060539 Css NA 1.824 mg/L PBTK NA 50% Human Human +DTXSID8060539 Css NA 12.08 mg/L PBTK NA 95% Human Human +DTXSID8060539 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8060539 Fup 0.00998 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8060539 Vd NA 2.09 L/kg 1compartment NA NA Rat Human +DTXSID8060539 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID8060539 TK.Half.Life NA 11.14 hours 1compartment NA NA Rat Human +DTXSID8060539 Css NA 0.3516 mg/L 3compartmentss NA 50% Rat Human +DTXSID8060539 Css NA 2.105 mg/L 3compartmentss NA 95% Rat Human +DTXSID8060539 Css NA 0.233 mg/L PBTK NA 50% Rat Human +DTXSID8060539 Css NA 1.363 mg/L PBTK NA 95% Rat Human +DTXSID8060614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8060614 Fup 0.0217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8060614 Vd NA 2.822 L/kg 1compartment NA NA Human Human +DTXSID8060614 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID8060614 TK.Half.Life NA 43.08 hours 1compartment NA NA Human Human +DTXSID8060614 Css NA 1.981 mg/L 3compartmentss NA 50% Human Human +DTXSID8060614 Css NA 13.72 mg/L 3compartmentss NA 95% Human Human +DTXSID8060614 Css NA 1.338 mg/L PBTK NA 50% Human Human +DTXSID8060614 Css NA 9.019 mg/L PBTK NA 95% Human Human +DTXSID8060614 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8060614 Fup 0.0217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8060614 Vd NA 2.11 L/kg 1compartment NA NA Rat Human +DTXSID8060614 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID8060614 TK.Half.Life NA 8.296 hours 1compartment NA NA Rat Human +DTXSID8060614 Css NA 0.2549 mg/L 3compartmentss NA 50% Rat Human +DTXSID8060614 Css NA 1.513 mg/L 3compartmentss NA 95% Rat Human +DTXSID8060614 Css NA 0.17 mg/L PBTK NA 50% Rat Human +DTXSID8060614 Css NA 0.9907 mg/L PBTK NA 95% Rat Human +DTXSID8060878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8060878 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8060878 Vd NA 3.124 L/kg 1compartment NA NA Human Human +DTXSID8060878 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID8060878 TK.Half.Life NA 90.37 hours 1compartment NA NA Human Human +DTXSID8060878 Css NA 1.855 mg/L 3compartmentss NA 50% Human Human +DTXSID8060878 Css NA 12.01 mg/L 3compartmentss NA 95% Human Human +DTXSID8060878 Css NA 1.289 mg/L PBTK NA 50% Human Human +DTXSID8060878 Css NA 8.009 mg/L PBTK NA 95% Human Human +DTXSID8060878 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8060878 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8060878 Vd NA 2.339 L/kg 1compartment NA NA Rat Human +DTXSID8060878 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID8060878 TK.Half.Life NA 12.09 hours 1compartment NA NA Rat Human +DTXSID8060878 Css NA 0.02026 mg/L 3compartmentss NA 50% Rat Human +DTXSID8060878 Css NA 0.1238 mg/L 3compartmentss NA 95% Rat Human +DTXSID8060878 Css NA 0.01352 mg/L PBTK NA 50% Rat Human +DTXSID8060878 Css NA 0.08127 mg/L PBTK NA 95% Rat Human +DTXSID8060905 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8060905 Fup 0.0674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8060905 Vd NA 0.4109 L/kg 1compartment NA NA Human Human +DTXSID8060905 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID8060905 TK.Half.Life NA 1.407 hours 1compartment NA NA Human Human +DTXSID8060905 Css NA 0.2912 mg/L 3compartmentss NA 50% Human Human +DTXSID8060905 Css NA 2.41 mg/L 3compartmentss NA 95% Human Human +DTXSID8060905 Css NA 0.1762 mg/L PBTK NA 50% Human Human +DTXSID8060905 Css NA 1.446 mg/L PBTK NA 95% Human Human +DTXSID8060905 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8060905 Fup 0.0674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8060905 Vd NA 0.3517 L/kg 1compartment NA NA Rat Human +DTXSID8060905 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8060905 TK.Half.Life NA 0.7321 hours 1compartment NA NA Rat Human +DTXSID8060905 Css NA 0.00429 mg/L 3compartmentss NA 50% Rat Human +DTXSID8060905 Css NA 0.03864 mg/L 3compartmentss NA 95% Rat Human +DTXSID8060905 Css NA 0.00246 mg/L PBTK NA 50% Rat Human +DTXSID8060905 Css NA 0.02165 mg/L PBTK NA 95% Rat Human +DTXSID8061684 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8061684 Fup 0.795 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8061684 Vd NA 2.241 L/kg 1compartment NA NA Human Human +DTXSID8061684 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID8061684 TK.Half.Life NA 18.32 hours 1compartment NA NA Human Human +DTXSID8061684 Css NA 0.6698 mg/L 3compartmentss NA 50% Human Human +DTXSID8061684 Css NA 4.834 mg/L 3compartmentss NA 95% Human Human +DTXSID8061684 Css NA 0.6986 mg/L PBTK NA 50% Human Human +DTXSID8061684 Css NA 3.327 mg/L PBTK NA 95% Human Human +DTXSID8061684 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8061684 Fup 0.795 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8061684 Vd NA 2.273 L/kg 1compartment NA NA Rat Human +DTXSID8061684 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID8061684 TK.Half.Life NA 6.313 hours 1compartment NA NA Rat Human +DTXSID8061684 Css NA 0.0123 mg/L 3compartmentss NA 50% Rat Human +DTXSID8061684 Css NA 0.1054 mg/L 3compartmentss NA 95% Rat Human +DTXSID8061684 Css NA 0.01257 mg/L PBTK NA 50% Rat Human +DTXSID8061684 Css NA 0.07752 mg/L PBTK NA 95% Rat Human +DTXSID80648969 Clint 1.627 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80648969 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80648969 Vd NA 3.943 L/kg 1compartment NA NA Human Human +DTXSID80648969 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID80648969 TK.Half.Life NA 17.42 hours 1compartment NA NA Human Human +DTXSID80648969 Css NA 0.2717 mg/L 3compartmentss NA 50% Human Human +DTXSID80648969 Css NA 1.841 mg/L 3compartmentss NA 95% Human Human +DTXSID80648969 Css NA 0.3512 mg/L PBTK NA 50% Human Human +DTXSID80648969 Css NA 1.623 mg/L PBTK NA 95% Human Human +DTXSID80648969 Clint 1.627 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80648969 Fup 0.397 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80648969 Vd NA 4.004 L/kg 1compartment NA NA Rat Human +DTXSID80648969 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID80648969 TK.Half.Life NA 9.275 hours 1compartment NA NA Rat Human +DTXSID80648969 Css NA 0.02635 mg/L 3compartmentss NA 50% Rat Human +DTXSID80648969 Css NA 0.1512 mg/L 3compartmentss NA 95% Rat Human +DTXSID80648969 Css NA 0.03544 mg/L PBTK NA 50% Rat Human +DTXSID80648969 Css NA 0.1242 mg/L PBTK NA 95% Rat Human +DTXSID80655299 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80655299 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80655299 Vd NA 0.5084 L/kg 1compartment NA NA Human Human +DTXSID80655299 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80655299 TK.Half.Life NA 1.428 hours 1compartment NA NA Human Human +DTXSID80655299 Css NA 0.2555 mg/L 3compartmentss NA 50% Human Human +DTXSID80655299 Css NA 1.592 mg/L 3compartmentss NA 95% Human Human +DTXSID80655299 Css NA 0.1774 mg/L PBTK NA 50% Human Human +DTXSID80655299 Css NA 1.02 mg/L PBTK NA 95% Human Human +DTXSID80655299 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80655299 Fup 0.266 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80655299 Vd NA 0.4955 L/kg 1compartment NA NA Rat Human +DTXSID80655299 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80655299 TK.Half.Life NA 0.7997 hours 1compartment NA NA Rat Human +DTXSID80655299 Css NA 0.02932 mg/L 3compartmentss NA 50% Rat Human +DTXSID80655299 Css NA 0.1353 mg/L 3compartmentss NA 95% Rat Human +DTXSID80655299 Css NA 0.01996 mg/L PBTK NA 50% Rat Human +DTXSID80655299 Css NA 0.08447 mg/L PBTK NA 95% Rat Human +DTXSID80676308 Clint 3.151 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80676308 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80676308 Vd NA 3.033 L/kg 1compartment NA NA Human Human +DTXSID80676308 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID80676308 TK.Half.Life NA 23.77 hours 1compartment NA NA Human Human +DTXSID80676308 Css NA 0.7831 mg/L 3compartmentss NA 50% Human Human +DTXSID80676308 Css NA 4.815 mg/L 3compartmentss NA 95% Human Human +DTXSID80676308 Css NA 0.6842 mg/L PBTK NA 50% Human Human +DTXSID80676308 Css NA 3.569 mg/L PBTK NA 95% Human Human +DTXSID80676308 Clint 3.151 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80676308 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80676308 Vd NA 2.771 L/kg 1compartment NA NA Rat Human +DTXSID80676308 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID80676308 TK.Half.Life NA 10.07 hours 1compartment NA NA Rat Human +DTXSID80676308 Css NA 0.08864 mg/L 3compartmentss NA 50% Rat Human +DTXSID80676308 Css NA 0.42 mg/L 3compartmentss NA 95% Rat Human +DTXSID80676308 Css NA 0.07873 mg/L PBTK NA 50% Rat Human +DTXSID80676308 Css NA 0.2992 mg/L PBTK NA 95% Rat Human +DTXSID8073928 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8073928 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8073928 Vd NA 3.084 L/kg 1compartment NA NA Human Human +DTXSID8073928 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID8073928 TK.Half.Life NA 87.29 hours 1compartment NA NA Human Human +DTXSID8073928 Css NA 3.38 mg/L 3compartmentss NA 50% Human Human +DTXSID8073928 Css NA 21.41 mg/L 3compartmentss NA 95% Human Human +DTXSID8073928 Css NA 2.339 mg/L PBTK NA 50% Human Human +DTXSID8073928 Css NA 14.33 mg/L PBTK NA 95% Human Human +DTXSID8073928 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8073928 Fup 0.0104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8073928 Vd NA 2.31 L/kg 1compartment NA NA Rat Human +DTXSID8073928 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID8073928 TK.Half.Life NA 12.34 hours 1compartment NA NA Rat Human +DTXSID8073928 Css NA 0.4474 mg/L 3compartmentss NA 50% Rat Human +DTXSID8073928 Css NA 2.393 mg/L 3compartmentss NA 95% Rat Human +DTXSID8073928 Css NA 0.3046 mg/L PBTK NA 50% Rat Human +DTXSID8073928 Css NA 1.564 mg/L PBTK NA 95% Rat Human +DTXSID8075205 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8075205 Fup 0.0196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID8075205 Vd NA 3.064 L/kg 1compartment NA NA Human Human +DTXSID8075205 Days.Css NA 11 Days PBTK NA NA Human Human +DTXSID8075205 TK.Half.Life NA 72.54 hours 1compartment NA NA Human Human +DTXSID8075205 Css NA 2.867 mg/L 3compartmentss NA 50% Human Human +DTXSID8075205 Css NA 18.53 mg/L 3compartmentss NA 95% Human Human +DTXSID8075205 Css NA 1.976 mg/L PBTK NA 50% Human Human +DTXSID8075205 Css NA 12.28 mg/L PBTK NA 95% Human Human +DTXSID8075205 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8075205 Fup 0.0196 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID8075205 Vd NA 2.295 L/kg 1compartment NA NA Rat Human +DTXSID8075205 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID8075205 TK.Half.Life NA 10.61 hours 1compartment NA NA Rat Human +DTXSID8075205 Css NA 0.3706 mg/L 3compartmentss NA 50% Rat Human +DTXSID8075205 Css NA 2.079 mg/L 3compartmentss NA 95% Rat Human +DTXSID8075205 Css NA 0.2525 mg/L PBTK NA 50% Rat Human +DTXSID8075205 Css NA 1.391 mg/L PBTK NA 95% Rat Human +DTXSID80859119 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80859119 Fup 0.023 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human +DTXSID80859119 Vd NA 0.8662 L/kg 1compartment NA NA Human Human +DTXSID80859119 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80859119 TK.Half.Life NA 6.849 hours 1compartment NA NA Human Human +DTXSID80859119 Css NA 1.248 mg/L 3compartmentss NA 50% Human Human +DTXSID80859119 Css NA 12.35 mg/L 3compartmentss NA 95% Human Human +DTXSID80859119 Css NA 0.7568 mg/L PBTK NA 50% Human Human +DTXSID80859119 Css NA 7.337 mg/L PBTK NA 95% Human Human +DTXSID80859119 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80859119 Fup 0.023 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Rat Human +DTXSID80859119 Vd NA 0.6482 L/kg 1compartment NA NA Rat Human +DTXSID80859119 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80859119 TK.Half.Life NA 3.086 hours 1compartment NA NA Rat Human +DTXSID80859119 Css NA 0.1668 mg/L 3compartmentss NA 50% Rat Human +DTXSID80859119 Css NA 1.268 mg/L 3compartmentss NA 95% Rat Human +DTXSID80859119 Css NA 0.09782 mg/L PBTK NA 50% Rat Human +DTXSID80859119 Css NA 0.7248 mg/L PBTK NA 95% Rat Human +DTXSID80859311 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80859311 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80859311 Vd NA 3.264 L/kg 1compartment NA NA Human Human +DTXSID80859311 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80859311 TK.Half.Life NA 12.28 hours 1compartment NA NA Human Human +DTXSID80859311 Css NA 0.3462 mg/L 3compartmentss NA 50% Human Human +DTXSID80859311 Css NA 2.318 mg/L 3compartmentss NA 95% Human Human +DTXSID80859311 Css NA 0.2498 mg/L PBTK NA 50% Human Human +DTXSID80859311 Css NA 1.608 mg/L PBTK NA 95% Human Human +DTXSID80859311 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80859311 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80859311 Vd NA 2.504 L/kg 1compartment NA NA Rat Human +DTXSID80859311 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80859311 TK.Half.Life NA 2.189 hours 1compartment NA NA Rat Human +DTXSID80859311 Css NA 0.04482 mg/L 3compartmentss NA 50% Rat Human +DTXSID80859311 Css NA 0.266 mg/L 3compartmentss NA 95% Rat Human +DTXSID80859311 Css NA 0.03212 mg/L PBTK NA 50% Rat Human +DTXSID80859311 Css NA 0.1882 mg/L PBTK NA 95% Rat Human +DTXSID80862527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80862527 Fup 0.0254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80862527 Vd NA 1.601 L/kg 1compartment NA NA Human Human +DTXSID80862527 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID80862527 TK.Half.Life NA 12.63 hours 1compartment NA NA Human Human +DTXSID80862527 Css NA 1.19 mg/L 3compartmentss NA 50% Human Human +DTXSID80862527 Css NA 10.43 mg/L 3compartmentss NA 95% Human Human +DTXSID80862527 Css NA 0.7517 mg/L PBTK NA 50% Human Human +DTXSID80862527 Css NA 6.376 mg/L PBTK NA 95% Human Human +DTXSID80862527 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80862527 Fup 0.0254 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80862527 Vd NA 1.192 L/kg 1compartment NA NA Rat Human +DTXSID80862527 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80862527 TK.Half.Life NA 4.715 hours 1compartment NA NA Rat Human +DTXSID80862527 Css NA 0.1531 mg/L 3compartmentss NA 50% Rat Human +DTXSID80862527 Css NA 1.053 mg/L 3compartmentss NA 95% Rat Human +DTXSID80862527 Css NA 0.09423 mg/L PBTK NA 50% Rat Human +DTXSID80862527 Css NA 0.6167 mg/L PBTK NA 95% Rat Human +DTXSID80864425 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80864425 Fup 0.889 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80864425 Vd NA 0.9859 L/kg 1compartment NA NA Human Human +DTXSID80864425 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80864425 TK.Half.Life NA 7.289 hours 1compartment NA NA Human Human +DTXSID80864425 Css NA 0.8704 mg/L 3compartmentss NA 50% Human Human +DTXSID80864425 Css NA 4.833 mg/L 3compartmentss NA 95% Human Human +DTXSID80864425 Css NA 0.7568 mg/L PBTK NA 50% Human Human +DTXSID80864425 Css NA 3.25 mg/L PBTK NA 95% Human Human +DTXSID80864425 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80864425 Fup 0.889 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80864425 Vd NA 0.9767 L/kg 1compartment NA NA Rat Human +DTXSID80864425 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80864425 TK.Half.Life NA 2.432 hours 1compartment NA NA Rat Human +DTXSID80864425 Css NA 0.05084 mg/L 3compartmentss NA 50% Rat Human +DTXSID80864425 Css NA 0.3048 mg/L 3compartmentss NA 95% Rat Human +DTXSID80864425 Css NA 0.04495 mg/L PBTK NA 50% Rat Human +DTXSID80864425 Css NA 0.1935 mg/L PBTK NA 95% Rat Human +DTXSID80867815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80867815 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80867815 Vd NA 1.374 L/kg 1compartment NA NA Human Human +DTXSID80867815 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80867815 TK.Half.Life NA 1.455 hours 1compartment NA NA Human Human +DTXSID80867815 Css NA 0.04546 mg/L 3compartmentss NA 50% Human Human +DTXSID80867815 Css NA 0.3796 mg/L 3compartmentss NA 95% Human Human +DTXSID80867815 Css NA 0.03656 mg/L PBTK NA 50% Human Human +DTXSID80867815 Css NA 0.2718 mg/L PBTK NA 95% Human Human +DTXSID80867815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80867815 Fup 0.452 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80867815 Vd NA 1.166 L/kg 1compartment NA NA Rat Human +DTXSID80867815 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80867815 TK.Half.Life NA 0.6048 hours 1compartment NA NA Rat Human +DTXSID80867815 Css NA 0.005534 mg/L 3compartmentss NA 50% Rat Human +DTXSID80867815 Css NA 0.03489 mg/L 3compartmentss NA 95% Rat Human +DTXSID80867815 Css NA 0.004533 mg/L PBTK NA 50% Rat Human +DTXSID80867815 Css NA 0.02445 mg/L PBTK NA 95% Rat Human +DTXSID80869253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80869253 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80869253 Vd NA 0.2003 L/kg 1compartment NA NA Human Human +DTXSID80869253 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80869253 TK.Half.Life NA 5.844 hours 1compartment NA NA Human Human +DTXSID80869253 Css NA 4.78 mg/L 3compartmentss NA 50% Human Human +DTXSID80869253 Css NA 45.58 mg/L 3compartmentss NA 95% Human Human +DTXSID80869253 Css NA 2.787 mg/L PBTK NA 50% Human Human +DTXSID80869253 Css NA 26.25 mg/L PBTK NA 95% Human Human +DTXSID80869253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80869253 Fup 0.006 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80869253 Vd NA 0.1873 L/kg 1compartment NA NA Rat Human +DTXSID80869253 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80869253 TK.Half.Life NA 3.681 hours 1compartment NA NA Rat Human +DTXSID80869253 Css NA 0.2358 mg/L 3compartmentss NA 50% Rat Human +DTXSID80869253 Css NA 2.554 mg/L 3compartmentss NA 95% Rat Human +DTXSID80869253 Css NA 0.1303 mg/L PBTK NA 50% Rat Human +DTXSID80869253 Css NA 1.423 mg/L PBTK NA 95% Rat Human +DTXSID80869455 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80869455 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80869455 Vd NA 2.802 L/kg 1compartment NA NA Human Human +DTXSID80869455 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80869455 TK.Half.Life NA 6.102 hours 1compartment NA NA Human Human +DTXSID80869455 Css NA 0.1692 mg/L 3compartmentss NA 50% Human Human +DTXSID80869455 Css NA 1.137 mg/L 3compartmentss NA 95% Human Human +DTXSID80869455 Css NA 0.1482 mg/L PBTK NA 50% Human Human +DTXSID80869455 Css NA 0.8731 mg/L PBTK NA 95% Human Human +DTXSID80869455 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80869455 Fup 0.96 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80869455 Vd NA 2.225 L/kg 1compartment NA NA Rat Human +DTXSID80869455 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80869455 TK.Half.Life NA 1.564 hours 1compartment NA NA Rat Human +DTXSID80869455 Css NA 0.0194 mg/L 3compartmentss NA 50% Rat Human +DTXSID80869455 Css NA 0.1004 mg/L 3compartmentss NA 95% Rat Human +DTXSID80869455 Css NA 0.01729 mg/L PBTK NA 50% Rat Human +DTXSID80869455 Css NA 0.07564 mg/L PBTK NA 95% Rat Human +DTXSID80870086 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID80870086 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80870086 Vd NA 1.929 L/kg 1compartment NA NA Human Human +DTXSID80870086 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID80870086 TK.Half.Life NA 85.76 hours 1compartment NA NA Human Human +DTXSID80870086 Css NA 6.927 mg/L 3compartmentss NA 50% Human Human +DTXSID80870086 Css NA 43.68 mg/L 3compartmentss NA 95% Human Human +DTXSID80870086 Css NA 4.491 mg/L PBTK NA 50% Human Human +DTXSID80870086 Css NA 26.89 mg/L PBTK NA 95% Human Human +DTXSID80870086 Clint 3 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID80870086 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80870086 Vd NA 1.444 L/kg 1compartment NA NA Rat Human +DTXSID80870086 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID80870086 TK.Half.Life NA 26.46 hours 1compartment NA NA Rat Human +DTXSID80870086 Css NA 0.8146 mg/L 3compartmentss NA 50% Rat Human +DTXSID80870086 Css NA 3.953 mg/L 3compartmentss NA 95% Rat Human +DTXSID80870086 Css NA 0.5112 mg/L PBTK NA 50% Rat Human +DTXSID80870086 Css NA 2.316 mg/L PBTK NA 95% Rat Human +DTXSID80872343 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80872343 Fup 0.396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80872343 Vd NA 0.4358 L/kg 1compartment NA NA Human Human +DTXSID80872343 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80872343 TK.Half.Life NA 0.7118 hours 1compartment NA NA Human Human +DTXSID80872343 Css NA 0.1144 mg/L 3compartmentss NA 50% Human Human +DTXSID80872343 Css NA 0.7678 mg/L 3compartmentss NA 95% Human Human +DTXSID80872343 Css NA 0.08099 mg/L PBTK NA 50% Human Human +DTXSID80872343 Css NA 0.5061 mg/L PBTK NA 95% Human Human +DTXSID80872343 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80872343 Fup 0.396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80872343 Vd NA 0.4597 L/kg 1compartment NA NA Rat Human +DTXSID80872343 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80872343 TK.Half.Life NA 0.4104 hours 1compartment NA NA Rat Human +DTXSID80872343 Css NA 0.0135 mg/L 3compartmentss NA 50% Rat Human +DTXSID80872343 Css NA 0.07267 mg/L 3compartmentss NA 95% Rat Human +DTXSID80872343 Css NA 0.009432 mg/L PBTK NA 50% Rat Human +DTXSID80872343 Css NA 0.04574 mg/L PBTK NA 95% Rat Human +DTXSID80873219 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80873219 Fup 0.011 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80873219 Vd NA 0.5787 L/kg 1compartment NA NA Human Human +DTXSID80873219 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80873219 TK.Half.Life NA 8.531 hours 1compartment NA NA Human Human +DTXSID80873219 Css NA 2.524 mg/L 3compartmentss NA 50% Human Human +DTXSID80873219 Css NA 24.71 mg/L 3compartmentss NA 95% Human Human +DTXSID80873219 Css NA 1.504 mg/L PBTK NA 50% Human Human +DTXSID80873219 Css NA 14.53 mg/L PBTK NA 95% Human Human +DTXSID80873219 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80873219 Fup 0.011 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80873219 Vd NA 0.4383 L/kg 1compartment NA NA Rat Human +DTXSID80873219 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80873219 TK.Half.Life NA 4.156 hours 1compartment NA NA Rat Human +DTXSID80873219 Css NA 0.3376 mg/L 3compartmentss NA 50% Rat Human +DTXSID80873219 Css NA 2.724 mg/L 3compartmentss NA 95% Rat Human +DTXSID80873219 Css NA 0.1936 mg/L PBTK NA 50% Rat Human +DTXSID80873219 Css NA 1.538 mg/L PBTK NA 95% Rat Human +DTXSID80873976 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80873976 Fup 0.774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80873976 Vd NA 0.6721 L/kg 1compartment NA NA Human Human +DTXSID80873976 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80873976 TK.Half.Life NA 5.622 hours 1compartment NA NA Human Human +DTXSID80873976 Css NA 0.4128 mg/L 3compartmentss NA 50% Human Human +DTXSID80873976 Css NA 2.786 mg/L 3compartmentss NA 95% Human Human +DTXSID80873976 Css NA 0.3324 mg/L PBTK NA 50% Human Human +DTXSID80873976 Css NA 1.772 mg/L PBTK NA 95% Human Human +DTXSID80873976 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80873976 Fup 0.774 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80873976 Vd NA 0.7035 L/kg 1compartment NA NA Rat Human +DTXSID80873976 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80873976 TK.Half.Life NA 2.004 hours 1compartment NA NA Rat Human +DTXSID80873976 Css NA 0.001794 mg/L 3compartmentss NA 50% Rat Human +DTXSID80873976 Css NA 0.01133 mg/L 3compartmentss NA 95% Rat Human +DTXSID80873976 Css NA 0.001421 mg/L PBTK NA 50% Rat Human +DTXSID80873976 Css NA 0.006793 mg/L PBTK NA 95% Rat Human +DTXSID80879993 Clint 54.95 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80879993 Fup 0.0186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80879993 Vd NA 3.092 L/kg 1compartment NA NA Human Human +DTXSID80879993 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID80879993 TK.Half.Life NA 33.55 hours 1compartment NA NA Human Human +DTXSID80879993 Css NA 1.241 mg/L 3compartmentss NA 50% Human Human +DTXSID80879993 Css NA 7.85 mg/L 3compartmentss NA 95% Human Human +DTXSID80879993 Css NA 0.8601 mg/L PBTK NA 50% Human Human +DTXSID80879993 Css NA 5.315 mg/L PBTK NA 95% Human Human +DTXSID80879993 Clint 54.95 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80879993 Fup 0.0186 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80879993 Vd NA 2.316 L/kg 1compartment NA NA Rat Human +DTXSID80879993 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID80879993 TK.Half.Life NA 5.005 hours 1compartment NA NA Rat Human +DTXSID80879993 Css NA 0.1606 mg/L 3compartmentss NA 50% Rat Human +DTXSID80879993 Css NA 0.8777 mg/L 3compartmentss NA 95% Rat Human +DTXSID80879993 Css NA 0.1101 mg/L PBTK NA 50% Rat Human +DTXSID80879993 Css NA 0.5821 mg/L PBTK NA 95% Rat Human +DTXSID80880685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880685 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880685 Vd NA 1.283 L/kg 1compartment NA NA Human Human +DTXSID80880685 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80880685 TK.Half.Life NA 2.646 hours 1compartment NA NA Human Human +DTXSID80880685 Css NA 0.1778 mg/L 3compartmentss NA 50% Human Human +DTXSID80880685 Css NA 1.327 mg/L 3compartmentss NA 95% Human Human +DTXSID80880685 Css NA 0.1208 mg/L PBTK NA 50% Human Human +DTXSID80880685 Css NA 0.8546 mg/L PBTK NA 95% Human Human +DTXSID80880685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880685 Fup 0.151 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880685 Vd NA 1.01 L/kg 1compartment NA NA Rat Human +DTXSID80880685 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80880685 TK.Half.Life NA 1.085 hours 1compartment NA NA Rat Human +DTXSID80880685 Css NA 0.02295 mg/L 3compartmentss NA 50% Rat Human +DTXSID80880685 Css NA 0.1382 mg/L 3compartmentss NA 95% Rat Human +DTXSID80880685 Css NA 0.01542 mg/L PBTK NA 50% Rat Human +DTXSID80880685 Css NA 0.08626 mg/L PBTK NA 95% Rat Human +DTXSID80880706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880706 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880706 Vd NA 1.866 L/kg 1compartment NA NA Human Human +DTXSID80880706 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80880706 TK.Half.Life NA 2.077 hours 1compartment NA NA Human Human +DTXSID80880706 Css NA 0.05093 mg/L 3compartmentss NA 50% Human Human +DTXSID80880706 Css NA 0.4234 mg/L 3compartmentss NA 95% Human Human +DTXSID80880706 Css NA 0.0417 mg/L PBTK NA 50% Human Human +DTXSID80880706 Css NA 0.3068 mg/L PBTK NA 95% Human Human +DTXSID80880706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880706 Fup 0.476 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880706 Vd NA 1.518 L/kg 1compartment NA NA Rat Human +DTXSID80880706 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80880706 TK.Half.Life NA 0.7737 hours 1compartment NA NA Rat Human +DTXSID80880706 Css NA 0.006358 mg/L 3compartmentss NA 50% Rat Human +DTXSID80880706 Css NA 0.03986 mg/L 3compartmentss NA 95% Rat Human +DTXSID80880706 Css NA 0.005263 mg/L PBTK NA 50% Rat Human +DTXSID80880706 Css NA 0.0283 mg/L PBTK NA 95% Rat Human +DTXSID80880882 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880882 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880882 Vd NA 0.9901 L/kg 1compartment NA NA Human Human +DTXSID80880882 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80880882 TK.Half.Life NA 9.247 hours 1compartment NA NA Human Human +DTXSID80880882 Css NA 0.8827 mg/L 3compartmentss NA 50% Human Human +DTXSID80880882 Css NA 6.006 mg/L 3compartmentss NA 95% Human Human +DTXSID80880882 Css NA 0.7528 mg/L PBTK NA 50% Human Human +DTXSID80880882 Css NA 3.914 mg/L PBTK NA 95% Human Human +DTXSID80880882 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880882 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880882 Vd NA 0.9982 L/kg 1compartment NA NA Rat Human +DTXSID80880882 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80880882 TK.Half.Life NA 3.165 hours 1compartment NA NA Rat Human +DTXSID80880882 Css NA 0.01677 mg/L 3compartmentss NA 50% Rat Human +DTXSID80880882 Css NA 0.1404 mg/L 3compartmentss NA 95% Rat Human +DTXSID80880882 Css NA 0.01387 mg/L PBTK NA 50% Rat Human +DTXSID80880882 Css NA 0.09092 mg/L PBTK NA 95% Rat Human +DTXSID80880887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880887 Fup 0.0195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880887 Vd NA 155.6 L/kg 1compartment NA NA Human Human +DTXSID80880887 Days.Css NA 1221 Days PBTK NA NA Human Human +DTXSID80880887 TK.Half.Life NA 4572 hours 1compartment NA NA Human Human +DTXSID80880887 Css NA 0.1174 mg/L 3compartmentss NA 50% Human Human +DTXSID80880887 Css NA 0.7308 mg/L 3compartmentss NA 95% Human Human +DTXSID80880887 Css NA 2.367 mg/L PBTK NA 50% Human Human +DTXSID80880887 Css NA 13.58 mg/L PBTK NA 95% Human Human +DTXSID80880887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880887 Fup 0.0195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880887 Vd NA 136.4 L/kg 1compartment NA NA Rat Human +DTXSID80880887 Days.Css NA 767 Days PBTK NA NA Rat Human +DTXSID80880887 TK.Half.Life NA 685.6 hours 1compartment NA NA Rat Human +DTXSID80880887 Css NA 0.01374 mg/L 3compartmentss NA 50% Rat Human +DTXSID80880887 Css NA 0.06623 mg/L 3compartmentss NA 95% Rat Human +DTXSID80880887 Css NA 0.3068 mg/L PBTK NA 50% Rat Human +DTXSID80880887 Css NA 1.498 mg/L PBTK NA 95% Rat Human +DTXSID80880908 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880908 Fup 0.017 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880908 Vd NA 3.081 L/kg 1compartment NA NA Human Human +DTXSID80880908 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID80880908 TK.Half.Life NA 79.18 hours 1compartment NA NA Human Human +DTXSID80880908 Css NA 3.102 mg/L 3compartmentss NA 50% Human Human +DTXSID80880908 Css NA 20.48 mg/L 3compartmentss NA 95% Human Human +DTXSID80880908 Css NA 2.136 mg/L PBTK NA 50% Human Human +DTXSID80880908 Css NA 13.74 mg/L PBTK NA 95% Human Human +DTXSID80880908 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880908 Fup 0.017 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880908 Vd NA 2.308 L/kg 1compartment NA NA Rat Human +DTXSID80880908 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID80880908 TK.Half.Life NA 11.29 hours 1compartment NA NA Rat Human +DTXSID80880908 Css NA 0.4031 mg/L 3compartmentss NA 50% Rat Human +DTXSID80880908 Css NA 2.276 mg/L 3compartmentss NA 95% Rat Human +DTXSID80880908 Css NA 0.2751 mg/L PBTK NA 50% Rat Human +DTXSID80880908 Css NA 1.517 mg/L PBTK NA 95% Rat Human +DTXSID80880923 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880923 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80880923 Vd NA 2.097 L/kg 1compartment NA NA Human Human +DTXSID80880923 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80880923 TK.Half.Life NA 4.263 hours 1compartment NA NA Human Human +DTXSID80880923 Css NA 0.1514 mg/L 3compartmentss NA 50% Human Human +DTXSID80880923 Css NA 1.002 mg/L 3compartmentss NA 95% Human Human +DTXSID80880923 Css NA 0.1106 mg/L PBTK NA 50% Human Human +DTXSID80880923 Css NA 0.6876 mg/L PBTK NA 95% Human Human +DTXSID80880923 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880923 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80880923 Vd NA 1.616 L/kg 1compartment NA NA Rat Human +DTXSID80880923 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80880923 TK.Half.Life NA 1.413 hours 1compartment NA NA Rat Human +DTXSID80880923 Css NA 0.01913 mg/L 3compartmentss NA 50% Rat Human +DTXSID80880923 Css NA 0.1001 mg/L 3compartmentss NA 95% Rat Human +DTXSID80880923 Css NA 0.01394 mg/L PBTK NA 50% Rat Human +DTXSID80880923 Css NA 0.06932 mg/L PBTK NA 95% Rat Human +DTXSID80881091 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80881091 Fup 0.8851 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80881091 Vd NA 2.944 L/kg 1compartment NA NA Human Human +DTXSID80881091 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID80881091 TK.Half.Life NA 21.63 hours 1compartment NA NA Human Human +DTXSID80881091 Css NA 0.5754 mg/L 3compartmentss NA 50% Human Human +DTXSID80881091 Css NA 3.937 mg/L 3compartmentss NA 95% Human Human +DTXSID80881091 Css NA 0.6666 mg/L PBTK NA 50% Human Human +DTXSID80881091 Css NA 2.935 mg/L PBTK NA 95% Human Human +DTXSID80881091 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80881091 Fup 0.8851 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80881091 Vd NA 2.997 L/kg 1compartment NA NA Rat Human +DTXSID80881091 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80881091 TK.Half.Life NA 7.475 hours 1compartment NA NA Rat Human +DTXSID80881091 Css NA 0.0145 mg/L 3compartmentss NA 50% Rat Human +DTXSID80881091 Css NA 0.1148 mg/L 3compartmentss NA 95% Rat Human +DTXSID80881091 Css NA 0.01645 mg/L PBTK NA 50% Rat Human +DTXSID80881091 Css NA 0.08863 mg/L PBTK NA 95% Rat Human +DTXSID80891478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80891478 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80891478 Vd NA 1.06 L/kg 1compartment NA NA Human Human +DTXSID80891478 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80891478 TK.Half.Life NA 2.804 hours 1compartment NA NA Human Human +DTXSID80891478 Css NA 0.2858 mg/L 3compartmentss NA 50% Human Human +DTXSID80891478 Css NA 2.289 mg/L 3compartmentss NA 95% Human Human +DTXSID80891478 Css NA 0.1847 mg/L PBTK NA 50% Human Human +DTXSID80891478 Css NA 1.41 mg/L PBTK NA 95% Human Human +DTXSID80891478 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80891478 Fup 0.1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80891478 Vd NA 0.8301 L/kg 1compartment NA NA Rat Human +DTXSID80891478 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80891478 TK.Half.Life NA 1.209 hours 1compartment NA NA Rat Human +DTXSID80891478 Css NA 0.03663 mg/L 3compartmentss NA 50% Rat Human +DTXSID80891478 Css NA 0.2361 mg/L 3compartmentss NA 95% Rat Human +DTXSID80891478 Css NA 0.02329 mg/L PBTK NA 50% Rat Human +DTXSID80891478 Css NA 0.1427 mg/L PBTK NA 95% Rat Human +DTXSID80894126 Clint 118.1 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80894126 Fup 0.0558 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80894126 Vd NA 1.402 L/kg 1compartment NA NA Human Human +DTXSID80894126 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80894126 TK.Half.Life NA 2.064 hours 1compartment NA NA Human Human +DTXSID80894126 Css NA 0.08276 mg/L 3compartmentss NA 50% Human Human +DTXSID80894126 Css NA 0.7632 mg/L 3compartmentss NA 95% Human Human +DTXSID80894126 Css NA 0.0539 mg/L PBTK NA 50% Human Human +DTXSID80894126 Css NA 0.4669 mg/L PBTK NA 95% Human Human +DTXSID80894126 Clint 118.1 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80894126 Fup 0.0558 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80894126 Vd NA 1.106 L/kg 1compartment NA NA Rat Human +DTXSID80894126 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80894126 TK.Half.Life NA 0.8093 hours 1compartment NA NA Rat Human +DTXSID80894126 Css NA 0.004141 mg/L 3compartmentss NA 50% Rat Human +DTXSID80894126 Css NA 0.04259 mg/L 3compartmentss NA 95% Rat Human +DTXSID80894126 Css NA 0.002623 mg/L PBTK NA 50% Rat Human +DTXSID80894126 Css NA 0.02527 mg/L PBTK NA 95% Rat Human +DTXSID80904653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80904653 Fup 0.00725 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80904653 Vd NA 0.2022 L/kg 1compartment NA NA Human Human +DTXSID80904653 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80904653 TK.Half.Life NA 4.972 hours 1compartment NA NA Human Human +DTXSID80904653 Css NA 4.455 mg/L 3compartmentss NA 50% Human Human +DTXSID80904653 Css NA 44.83 mg/L 3compartmentss NA 95% Human Human +DTXSID80904653 Css NA 2.606 mg/L PBTK NA 50% Human Human +DTXSID80904653 Css NA 26.18 mg/L PBTK NA 95% Human Human +DTXSID80904653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80904653 Fup 0.00725 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80904653 Vd NA 0.193 L/kg 1compartment NA NA Rat Human +DTXSID80904653 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80904653 TK.Half.Life NA 3.194 hours 1compartment NA NA Rat Human +DTXSID80904653 Css NA 0.5908 mg/L 3compartmentss NA 50% Rat Human +DTXSID80904653 Css NA 4.64 mg/L 3compartmentss NA 95% Rat Human +DTXSID80904653 Css NA 0.3352 mg/L PBTK NA 50% Rat Human +DTXSID80904653 Css NA 2.617 mg/L PBTK NA 95% Rat Human +DTXSID80914272 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80914272 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80914272 Vd NA 0.6861 L/kg 1compartment NA NA Human Human +DTXSID80914272 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80914272 TK.Half.Life NA 4.933 hours 1compartment NA NA Human Human +DTXSID80914272 Css NA 0.4917 mg/L 3compartmentss NA 50% Human Human +DTXSID80914272 Css NA 1.995 mg/L 3compartmentss NA 95% Human Human +DTXSID80914272 Css NA 0.4036 mg/L PBTK NA 50% Human Human +DTXSID80914272 Css NA 1.416 mg/L PBTK NA 95% Human Human +DTXSID80914272 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80914272 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80914272 Vd NA 0.7273 L/kg 1compartment NA NA Rat Human +DTXSID80914272 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80914272 TK.Half.Life NA 1.782 hours 1compartment NA NA Rat Human +DTXSID80914272 Css NA 0.002523 mg/L 3compartmentss NA 50% Rat Human +DTXSID80914272 Css NA 0.01064 mg/L 3compartmentss NA 95% Rat Human +DTXSID80914272 Css NA 0.00201 mg/L PBTK NA 50% Rat Human +DTXSID80914272 Css NA 0.007232 mg/L PBTK NA 95% Rat Human +DTXSID80919666 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80919666 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80919666 Vd NA 0.3469 L/kg 1compartment NA NA Human Human +DTXSID80919666 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80919666 TK.Half.Life NA 1.205 hours 1compartment NA NA Human Human +DTXSID80919666 Css NA 0.3465 mg/L 3compartmentss NA 50% Human Human +DTXSID80919666 Css NA 2.085 mg/L 3compartmentss NA 95% Human Human +DTXSID80919666 Css NA 0.2275 mg/L PBTK NA 50% Human Human +DTXSID80919666 Css NA 1.314 mg/L PBTK NA 95% Human Human +DTXSID80919666 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80919666 Fup 0.206 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80919666 Vd NA 0.3442 L/kg 1compartment NA NA Rat Human +DTXSID80919666 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80919666 TK.Half.Life NA 0.7005 hours 1compartment NA NA Rat Human +DTXSID80919666 Css NA 0.03832 mg/L 3compartmentss NA 50% Rat Human +DTXSID80919666 Css NA 0.1683 mg/L 3compartmentss NA 95% Rat Human +DTXSID80919666 Css NA 0.02471 mg/L PBTK NA 50% Rat Human +DTXSID80919666 Css NA 0.1015 mg/L PBTK NA 95% Rat Human +DTXSID80923001 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80923001 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80923001 Vd NA 0.7907 L/kg 1compartment NA NA Human Human +DTXSID80923001 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID80923001 TK.Half.Life NA 5.119 hours 1compartment NA NA Human Human +DTXSID80923001 Css NA 0.7177 mg/L 3compartmentss NA 50% Human Human +DTXSID80923001 Css NA 4.901 mg/L 3compartmentss NA 95% Human Human +DTXSID80923001 Css NA 0.6061 mg/L PBTK NA 50% Human Human +DTXSID80923001 Css NA 3.247 mg/L PBTK NA 95% Human Human +DTXSID80923001 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80923001 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80923001 Vd NA 0.8276 L/kg 1compartment NA NA Rat Human +DTXSID80923001 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID80923001 TK.Half.Life NA 1.825 hours 1compartment NA NA Rat Human +DTXSID80923001 Css NA 0.01784 mg/L 3compartmentss NA 50% Rat Human +DTXSID80923001 Css NA 0.1285 mg/L 3compartmentss NA 95% Rat Human +DTXSID80923001 Css NA 0.01476 mg/L PBTK NA 50% Rat Human +DTXSID80923001 Css NA 0.08324 mg/L PBTK NA 95% Rat Human +DTXSID80965062 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID80965062 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID80965062 Vd NA 2.429 L/kg 1compartment NA NA Human Human +DTXSID80965062 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID80965062 TK.Half.Life NA 27.51 hours 1compartment NA NA Human Human +DTXSID80965062 Css NA 1.584 mg/L 3compartmentss NA 50% Human Human +DTXSID80965062 Css NA 12.31 mg/L 3compartmentss NA 95% Human Human +DTXSID80965062 Css NA 1.059 mg/L PBTK NA 50% Human Human +DTXSID80965062 Css NA 7.844 mg/L PBTK NA 95% Human Human +DTXSID80965062 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID80965062 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID80965062 Vd NA 1.851 L/kg 1compartment NA NA Rat Human +DTXSID80965062 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID80965062 TK.Half.Life NA 7.79 hours 1compartment NA NA Rat Human +DTXSID80965062 Css NA 0.2029 mg/L 3compartmentss NA 50% Rat Human +DTXSID80965062 Css NA 1.335 mg/L 3compartmentss NA 95% Rat Human +DTXSID80965062 Css NA 0.133 mg/L PBTK NA 50% Rat Human +DTXSID80965062 Css NA 0.8265 mg/L PBTK NA 95% Rat Human +DTXSID901007381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID901007381 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID901007381 Vd NA 2.309 L/kg 1compartment NA NA Human Human +DTXSID901007381 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID901007381 TK.Half.Life NA 20.36 hours 1compartment NA NA Human Human +DTXSID901007381 Css NA 1.216 mg/L 3compartmentss NA 50% Human Human +DTXSID901007381 Css NA 9.487 mg/L 3compartmentss NA 95% Human Human +DTXSID901007381 Css NA 0.8011 mg/L PBTK NA 50% Human Human +DTXSID901007381 Css NA 6.008 mg/L PBTK NA 95% Human Human +DTXSID901007381 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID901007381 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID901007381 Vd NA 1.723 L/kg 1compartment NA NA Rat Human +DTXSID901007381 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID901007381 TK.Half.Life NA 5.682 hours 1compartment NA NA Rat Human +DTXSID901007381 Css NA 0.1559 mg/L 3compartmentss NA 50% Rat Human +DTXSID901007381 Css NA 0.9637 mg/L 3compartmentss NA 95% Rat Human +DTXSID901007381 Css NA 0.1007 mg/L PBTK NA 50% Rat Human +DTXSID901007381 Css NA 0.5917 mg/L PBTK NA 95% Rat Human +DTXSID901009337 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID901009337 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID901009337 Vd NA 1.065 L/kg 1compartment NA NA Human Human +DTXSID901009337 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID901009337 TK.Half.Life NA 47.54 hours 1compartment NA NA Human Human +DTXSID901009337 Css NA 6.924 mg/L 3compartmentss NA 50% Human Human +DTXSID901009337 Css NA 65.88 mg/L 3compartmentss NA 95% Human Human +DTXSID901009337 Css NA 4.166 mg/L PBTK NA 50% Human Human +DTXSID901009337 Css NA 39.09 mg/L PBTK NA 95% Human Human +DTXSID901009337 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID901009337 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID901009337 Vd NA 0.7775 L/kg 1compartment NA NA Rat Human +DTXSID901009337 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID901009337 TK.Half.Life NA 20.71 hours 1compartment NA NA Rat Human +DTXSID901009337 Css NA 0.3538 mg/L 3compartmentss NA 50% Rat Human +DTXSID901009337 Css NA 3.636 mg/L 3compartmentss NA 95% Rat Human +DTXSID901009337 Css NA 0.2028 mg/L PBTK NA 50% Rat Human +DTXSID901009337 Css NA 2.044 mg/L PBTK NA 95% Rat Human +DTXSID901017944 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID901017944 Fup 0.0663 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID901017944 Vd NA 0.3193 L/kg 1compartment NA NA Human Human +DTXSID901017944 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID901017944 TK.Half.Life NA 2.957 hours 1compartment NA NA Human Human +DTXSID901017944 Css NA 1.456 mg/L 3compartmentss NA 50% Human Human +DTXSID901017944 Css NA 9.906 mg/L 3compartmentss NA 95% Human Human +DTXSID901017944 Css NA 0.888 mg/L PBTK NA 50% Human Human +DTXSID901017944 Css NA 5.843 mg/L PBTK NA 95% Human Human +DTXSID901017944 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID901017944 Fup 0.0663 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID901017944 Vd NA 0.29 L/kg 1compartment NA NA Rat Human +DTXSID901017944 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID901017944 TK.Half.Life NA 1.659 hours 1compartment NA NA Rat Human +DTXSID901017944 Css NA 0.1812 mg/L 3compartmentss NA 50% Rat Human +DTXSID901017944 Css NA 0.8798 mg/L 3compartmentss NA 95% Rat Human +DTXSID901017944 Css NA 0.1064 mg/L PBTK NA 50% Rat Human +DTXSID901017944 Css NA 0.5041 mg/L PBTK NA 95% Rat Human +DTXSID901122470 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID901122470 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID901122470 Vd NA 2.213 L/kg 1compartment NA NA Human Human +DTXSID901122470 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID901122470 TK.Half.Life NA 16.09 hours 1compartment NA NA Human Human +DTXSID901122470 Css NA 0.8579 mg/L 3compartmentss NA 50% Human Human +DTXSID901122470 Css NA 5.072 mg/L 3compartmentss NA 95% Human Human +DTXSID901122470 Css NA 0.6043 mg/L PBTK NA 50% Human Human +DTXSID901122470 Css NA 3.314 mg/L PBTK NA 95% Human Human +DTXSID901122470 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID901122470 Fup 0.148 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID901122470 Vd NA 1.687 L/kg 1compartment NA NA Rat Human +DTXSID901122470 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID901122470 TK.Half.Life NA 4.741 hours 1compartment NA NA Rat Human +DTXSID901122470 Css NA 0.1051 mg/L 3compartmentss NA 50% Rat Human +DTXSID901122470 Css NA 0.4672 mg/L 3compartmentss NA 95% Rat Human +DTXSID901122470 Css NA 0.07314 mg/L PBTK NA 50% Rat Human +DTXSID901122470 Css NA 0.302 mg/L PBTK NA 95% Rat Human +DTXSID901179952 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID901179952 Fup 0.0944 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID901179952 Vd NA 3.08 L/kg 1compartment NA NA Human Human +DTXSID901179952 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID901179952 TK.Half.Life NA 45.24 hours 1compartment NA NA Human Human +DTXSID901179952 Css NA 1.684 mg/L 3compartmentss NA 50% Human Human +DTXSID901179952 Css NA 11.17 mg/L 3compartmentss NA 95% Human Human +DTXSID901179952 Css NA 1.181 mg/L PBTK NA 50% Human Human +DTXSID901179952 Css NA 7.519 mg/L PBTK NA 95% Human Human +DTXSID901179952 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID901179952 Fup 0.0944 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID901179952 Vd NA 2.311 L/kg 1compartment NA NA Rat Human +DTXSID901179952 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID901179952 TK.Half.Life NA 6.697 hours 1compartment NA NA Rat Human +DTXSID901179952 Css NA 0.2192 mg/L 3compartmentss NA 50% Rat Human +DTXSID901179952 Css NA 1.244 mg/L 3compartmentss NA 95% Rat Human +DTXSID901179952 Css NA 0.1519 mg/L PBTK NA 50% Rat Human +DTXSID901179952 Css NA 0.8347 mg/L PBTK NA 95% Rat Human +DTXSID90145616 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90145616 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90145616 Vd NA 2.772 L/kg 1compartment NA NA Human Human +DTXSID90145616 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID90145616 TK.Half.Life NA 25.71 hours 1compartment NA NA Human Human +DTXSID90145616 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human +DTXSID90145616 Css NA 7.688 mg/L 3compartmentss NA 95% Human Human +DTXSID90145616 Css NA 0.7753 mg/L PBTK NA 50% Human Human +DTXSID90145616 Css NA 5.07 mg/L PBTK NA 95% Human Human +DTXSID90145616 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90145616 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90145616 Vd NA 2.077 L/kg 1compartment NA NA Rat Human +DTXSID90145616 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID90145616 TK.Half.Life NA 5.32 hours 1compartment NA NA Rat Human +DTXSID90145616 Css NA 0.147 mg/L 3compartmentss NA 50% Rat Human +DTXSID90145616 Css NA 0.793 mg/L 3compartmentss NA 95% Rat Human +DTXSID90145616 Css NA 0.09875 mg/L PBTK NA 50% Rat Human +DTXSID90145616 Css NA 0.5175 mg/L PBTK NA 95% Rat Human +DTXSID90154283 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90154283 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90154283 Vd NA 0.7296 L/kg 1compartment NA NA Human Human +DTXSID90154283 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90154283 TK.Half.Life NA 5.243 hours 1compartment NA NA Human Human +DTXSID90154283 Css NA 0.7527 mg/L 3compartmentss NA 50% Human Human +DTXSID90154283 Css NA 2.988 mg/L 3compartmentss NA 95% Human Human +DTXSID90154283 Css NA 0.6265 mg/L PBTK NA 50% Human Human +DTXSID90154283 Css NA 2.067 mg/L PBTK NA 95% Human Human +DTXSID90154283 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90154283 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90154283 Vd NA 0.7665 L/kg 1compartment NA NA Rat Human +DTXSID90154283 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90154283 TK.Half.Life NA 1.878 hours 1compartment NA NA Rat Human +DTXSID90154283 Css NA 0.01362 mg/L 3compartmentss NA 50% Rat Human +DTXSID90154283 Css NA 0.07445 mg/L 3compartmentss NA 95% Rat Human +DTXSID90154283 Css NA 0.01102 mg/L PBTK NA 50% Rat Human +DTXSID90154283 Css NA 0.05292 mg/L PBTK NA 95% Rat Human +DTXSID90158605 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90158605 Fup 0.63 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90158605 Vd NA 7.15 L/kg 1compartment NA NA Human Human +DTXSID90158605 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90158605 TK.Half.Life NA 7.728 hours 1compartment NA NA Human Human +DTXSID90158605 Css NA 0.04216 mg/L 3compartmentss NA 50% Human Human +DTXSID90158605 Css NA 0.5115 mg/L 3compartmentss NA 95% Human Human +DTXSID90158605 Css NA 0.0795 mg/L PBTK NA 50% Human Human +DTXSID90158605 Css NA 0.5533 mg/L PBTK NA 95% Human Human +DTXSID90158605 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90158605 Fup 0.63 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90158605 Vd NA 7.278 L/kg 1compartment NA NA Rat Human +DTXSID90158605 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90158605 TK.Half.Life NA 4.049 hours 1compartment NA NA Rat Human +DTXSID90158605 Css NA 0.004558 mg/L 3compartmentss NA 50% Rat Human +DTXSID90158605 Css NA 0.05428 mg/L 3compartmentss NA 95% Rat Human +DTXSID90158605 Css NA 0.009296 mg/L PBTK NA 50% Rat Human +DTXSID90158605 Css NA 0.0539 mg/L PBTK NA 95% Rat Human +DTXSID90164605 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90164605 Fup 0.678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90164605 Vd NA 0.7504 L/kg 1compartment NA NA Human Human +DTXSID90164605 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90164605 TK.Half.Life NA 7.197 hours 1compartment NA NA Human Human +DTXSID90164605 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human +DTXSID90164605 Css NA 6.981 mg/L 3compartmentss NA 95% Human Human +DTXSID90164605 Css NA 0.8778 mg/L PBTK NA 50% Human Human +DTXSID90164605 Css NA 4.479 mg/L PBTK NA 95% Human Human +DTXSID90164605 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90164605 Fup 0.678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90164605 Vd NA 0.7577 L/kg 1compartment NA NA Rat Human +DTXSID90164605 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90164605 TK.Half.Life NA 2.467 hours 1compartment NA NA Rat Human +DTXSID90164605 Css NA 0.06502 mg/L 3compartmentss NA 50% Rat Human +DTXSID90164605 Css NA 0.4098 mg/L 3compartmentss NA 95% Rat Human +DTXSID90164605 Css NA 0.05304 mg/L PBTK NA 50% Rat Human +DTXSID90164605 Css NA 0.2514 mg/L PBTK NA 95% Rat Human +DTXSID90166700 Clint 14.45 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90166700 Fup 0.0971 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90166700 Vd NA 1.6 L/kg 1compartment NA NA Human Human +DTXSID90166700 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90166700 TK.Half.Life NA 4.93 hours 1compartment NA NA Human Human +DTXSID90166700 Css NA 0.2926 mg/L 3compartmentss NA 50% Human Human +DTXSID90166700 Css NA 2.516 mg/L 3compartmentss NA 95% Human Human +DTXSID90166700 Css NA 0.2147 mg/L PBTK NA 50% Human Human +DTXSID90166700 Css NA 1.67 mg/L PBTK NA 95% Human Human +DTXSID90166700 Clint 14.45 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90166700 Fup 0.0971 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90166700 Vd NA 1.555 L/kg 1compartment NA NA Rat Human +DTXSID90166700 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90166700 TK.Half.Life NA 2.888 hours 1compartment NA NA Rat Human +DTXSID90166700 Css NA 0.01366 mg/L 3compartmentss NA 50% Rat Human +DTXSID90166700 Css NA 0.1331 mg/L 3compartmentss NA 95% Rat Human +DTXSID90166700 Css NA 0.01004 mg/L PBTK NA 50% Rat Human +DTXSID90166700 Css NA 0.08573 mg/L PBTK NA 95% Rat Human +DTXSID90174648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90174648 Fup 0.944 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90174648 Vd NA 0.7027 L/kg 1compartment NA NA Human Human +DTXSID90174648 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90174648 TK.Half.Life NA 4.817 hours 1compartment NA NA Human Human +DTXSID90174648 Css NA 0.4172 mg/L 3compartmentss NA 50% Human Human +DTXSID90174648 Css NA 2.303 mg/L 3compartmentss NA 95% Human Human +DTXSID90174648 Css NA 0.3432 mg/L PBTK NA 50% Human Human +DTXSID90174648 Css NA 1.53 mg/L PBTK NA 95% Human Human +DTXSID90174648 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90174648 Fup 0.944 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90174648 Vd NA 0.7468 L/kg 1compartment NA NA Rat Human +DTXSID90174648 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90174648 TK.Half.Life NA 1.744 hours 1compartment NA NA Rat Human +DTXSID90174648 Css NA 0.001879 mg/L 3compartmentss NA 50% Rat Human +DTXSID90174648 Css NA 0.01056 mg/L 3compartmentss NA 95% Rat Human +DTXSID90174648 Css NA 0.001502 mg/L PBTK NA 50% Rat Human +DTXSID90174648 Css NA 0.006563 mg/L PBTK NA 95% Rat Human +DTXSID90179850 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90179850 Fup 0.799 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90179850 Vd NA 0.6249 L/kg 1compartment NA NA Human Human +DTXSID90179850 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90179850 TK.Half.Life NA 5.067 hours 1compartment NA NA Human Human +DTXSID90179850 Css NA 1.01 mg/L 3compartmentss NA 50% Human Human +DTXSID90179850 Css NA 5.957 mg/L 3compartmentss NA 95% Human Human +DTXSID90179850 Css NA 0.7891 mg/L PBTK NA 50% Human Human +DTXSID90179850 Css NA 3.763 mg/L PBTK NA 95% Human Human +DTXSID90179850 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90179850 Fup 0.799 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90179850 Vd NA 0.7133 L/kg 1compartment NA NA Rat Human +DTXSID90179850 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90179850 TK.Half.Life NA 1.656 hours 1compartment NA NA Rat Human +DTXSID90179850 Css NA 0.05332 mg/L 3compartmentss NA 50% Rat Human +DTXSID90179850 Css NA 0.2848 mg/L 3compartmentss NA 95% Rat Human +DTXSID90179850 Css NA 0.043 mg/L PBTK NA 50% Rat Human +DTXSID90179850 Css NA 0.1765 mg/L PBTK NA 95% Rat Human DTXSID90185198 Clint 5.05 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID90185198 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID90185198 Vd NA 2.325 L/kg 1compartment NA NA Human Human -DTXSID90185198 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID90185198 TK.Half.Life NA 53.86 hours 1compartment NA NA Human Human -DTXSID90185198 Css NA 3.362 mg/L 3compartmentss NA 50% Human Human -DTXSID90185198 Css NA 19.39 mg/L 3compartmentss NA 95% Human Human -DTXSID90185198 Css NA 2.25 mg/L PBTK NA 50% Human Human -DTXSID90185198 Css NA 12.5 mg/L PBTK NA 95% Human Human +DTXSID90185198 Vd NA 2.351 L/kg 1compartment NA NA Human Human +DTXSID90185198 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID90185198 TK.Half.Life NA 55.36 hours 1compartment NA NA Human Human +DTXSID90185198 Css NA 3.287 mg/L 3compartmentss NA 50% Human Human +DTXSID90185198 Css NA 19.81 mg/L 3compartmentss NA 95% Human Human +DTXSID90185198 Css NA 2.199 mg/L PBTK NA 50% Human Human +DTXSID90185198 Css NA 12.65 mg/L PBTK NA 95% Human Human DTXSID90185198 Clint 5.05 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID90185198 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID90185198 Vd NA 1.742 L/kg 1compartment NA NA Rat Human +DTXSID90185198 Vd NA 1.762 L/kg 1compartment NA NA Rat Human DTXSID90185198 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID90185198 TK.Half.Life NA 14.17 hours 1compartment NA NA Rat Human -DTXSID90185198 Css NA 1.76 mg/L 3compartmentss NA 50% Rat Human -DTXSID90185198 Css NA 7.754 mg/L 3compartmentss NA 95% Rat Human -DTXSID90185198 Css NA 1.116 mg/L PBTK NA 50% Rat Human -DTXSID90185198 Css NA 4.638 mg/L PBTK NA 95% Rat Human +DTXSID90185198 TK.Half.Life NA 14.37 hours 1compartment NA NA Rat Human +DTXSID90185198 Css NA 0.4037 mg/L 3compartmentss NA 50% Rat Human +DTXSID90185198 Css NA 1.726 mg/L 3compartmentss NA 95% Rat Human +DTXSID90185198 Css NA 0.2654 mg/L PBTK NA 50% Rat Human +DTXSID90185198 Css NA 1.079 mg/L PBTK NA 95% Rat Human +DTXSID90197271 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90197271 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90197271 Vd NA 0.9666 L/kg 1compartment NA NA Human Human +DTXSID90197271 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90197271 TK.Half.Life NA 0.8591 hours 1compartment NA NA Human Human +DTXSID90197271 Css NA 0.03206 mg/L 3compartmentss NA 50% Human Human +DTXSID90197271 Css NA 0.3661 mg/L 3compartmentss NA 95% Human Human +DTXSID90197271 Css NA 0.02632 mg/L PBTK NA 50% Human Human +DTXSID90197271 Css NA 0.2541 mg/L PBTK NA 95% Human Human +DTXSID90197271 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90197271 Fup 0.6 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90197271 Vd NA 0.9129 L/kg 1compartment NA NA Rat Human +DTXSID90197271 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90197271 TK.Half.Life NA 0.4014 hours 1compartment NA NA Rat Human +DTXSID90197271 Css NA 0.003937 mg/L 3compartmentss NA 50% Rat Human +DTXSID90197271 Css NA 0.03668 mg/L 3compartmentss NA 95% Rat Human +DTXSID90197271 Css NA 0.003302 mg/L PBTK NA 50% Rat Human +DTXSID90197271 Css NA 0.02464 mg/L PBTK NA 95% Rat Human +DTXSID90198647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90198647 Fup 0.0221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90198647 Vd NA 7.721 L/kg 1compartment NA NA Human Human +DTXSID90198647 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID90198647 TK.Half.Life NA 63.13 hours 1compartment NA NA Human Human +DTXSID90198647 Css NA 0.805 mg/L 3compartmentss NA 50% Human Human +DTXSID90198647 Css NA 8.932 mg/L 3compartmentss NA 95% Human Human +DTXSID90198647 Css NA 0.8309 mg/L PBTK NA 50% Human Human +DTXSID90198647 Css NA 7.326 mg/L PBTK NA 95% Human Human +DTXSID90198647 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90198647 Fup 0.0221 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90198647 Vd NA 6.033 L/kg 1compartment NA NA Rat Human +DTXSID90198647 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID90198647 TK.Half.Life NA 25.82 hours 1compartment NA NA Rat Human +DTXSID90198647 Css NA 0.09904 mg/L 3compartmentss NA 50% Rat Human +DTXSID90198647 Css NA 0.9167 mg/L 3compartmentss NA 95% Rat Human +DTXSID90198647 Css NA 0.104 mg/L PBTK NA 50% Rat Human +DTXSID90198647 Css NA 0.6966 mg/L PBTK NA 95% Rat Human DTXSID9020031 Clint NA 746.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020031 Fup NA 0.1731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020031 Vd NA 1.471 L/kg 1compartment NA NA Human Human +DTXSID9020031 Vd NA 2.7 L/kg 1compartment NA NA Human Human DTXSID9020031 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020031 TK.Half.Life NA 1.214 hours 1compartment NA NA Human Human -DTXSID9020031 Css NA 0.00463 mg/L 3compartmentss NA 50% Human Human -DTXSID9020031 Css NA 0.03425 mg/L 3compartmentss NA 95% Human Human -DTXSID9020031 Css NA 0.003252 mg/L PBTK NA 50% Human Human -DTXSID9020031 Css NA 0.02243 mg/L PBTK NA 95% Human Human +DTXSID9020031 TK.Half.Life NA 2.088 hours 1compartment NA NA Human Human +DTXSID9020031 Css NA 0.002808 mg/L 3compartmentss NA 50% Human Human +DTXSID9020031 Css NA 0.03475 mg/L 3compartmentss NA 95% Human Human +DTXSID9020031 Css NA 0.00219 mg/L PBTK NA 50% Human Human +DTXSID9020031 Css NA 0.02575 mg/L PBTK NA 95% Human Human DTXSID9020031 Clint NA 746.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020031 Fup NA 0.1731 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020031 Vd NA 1.153 L/kg 1compartment NA NA Rat Human +DTXSID9020031 Vd NA 2.195 L/kg 1compartment NA NA Rat Human DTXSID9020031 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020031 TK.Half.Life NA 0.4183 hours 1compartment NA NA Rat Human -DTXSID9020031 Css NA 0.002578 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020031 Css NA 0.01539 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020031 Css NA 0.001729 mg/L PBTK NA 50% Rat Human -DTXSID9020031 Css NA 0.009983 mg/L PBTK NA 95% Rat Human +DTXSID9020031 TK.Half.Life NA 0.7322 hours 1compartment NA NA Rat Human +DTXSID9020031 Css NA 9.385e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020031 Css NA 0.001476 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020031 Css NA 7.134e-05 mg/L PBTK NA 50% Rat Human +DTXSID9020031 Css NA 0.001048 mg/L PBTK NA 95% Rat Human DTXSID9020035 Clint 11.28 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID9020035 Fup 0.1045 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID9020035 Vd NA 0.7552 L/kg 1compartment NA NA Human Human +DTXSID9020035 Vd NA 2.207 L/kg 1compartment NA NA Human Human DTXSID9020035 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020035 TK.Half.Life NA 2.976 hours 1compartment NA NA Human Human -DTXSID9020035 Css NA 0.429 mg/L 3compartmentss NA 50% Human Human -DTXSID9020035 Css NA 2.515 mg/L 3compartmentss NA 95% Human Human -DTXSID9020035 Css NA 0.2784 mg/L PBTK NA 50% Human Human -DTXSID9020035 Css NA 1.585 mg/L PBTK NA 95% Human Human +DTXSID9020035 TK.Half.Life NA 13.12 hours 1compartment NA NA Human Human +DTXSID9020035 Css NA 0.6396 mg/L 3compartmentss NA 50% Human Human +DTXSID9020035 Css NA 3.744 mg/L 3compartmentss NA 95% Human Human +DTXSID9020035 Css NA 0.4427 mg/L PBTK NA 50% Human Human +DTXSID9020035 Css NA 2.508 mg/L PBTK NA 95% Human Human DTXSID9020035 Clint 11.28 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID9020035 Fup 0.1045 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID9020035 Vd NA 0.6159 L/kg 1compartment NA NA Rat Human +DTXSID9020035 Vd NA 1.669 L/kg 1compartment NA NA Rat Human DTXSID9020035 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020035 TK.Half.Life NA 1.426 hours 1compartment NA NA Rat Human -DTXSID9020035 Css NA 0.2292 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020035 Css NA 0.9943 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020035 Css NA 0.1409 mg/L PBTK NA 50% Rat Human -DTXSID9020035 Css NA 0.5845 mg/L PBTK NA 95% Rat Human +DTXSID9020035 TK.Half.Life NA 3.918 hours 1compartment NA NA Rat Human +DTXSID9020035 Css NA 0.07922 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020035 Css NA 0.348 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020035 Css NA 0.05441 mg/L PBTK NA 50% Rat Human +DTXSID9020035 Css NA 0.2268 mg/L PBTK NA 95% Rat Human DTXSID9020081 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID9020081 Fup 0.39 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID9020081 Vd NA 1.458 L/kg 1compartment NA NA Human Human DTXSID9020081 Days.Css NA 5 Days PBTK NA NA Human Human DTXSID9020081 TK.Half.Life NA 30.23 hours 1compartment NA NA Human Human -DTXSID9020081 Css NA 1.359 mg/L 3compartmentss NA 50% Human Human -DTXSID9020081 Css NA 6.678 mg/L 3compartmentss NA 95% Human Human -DTXSID9020081 Css NA 1.733 mg/L PBTK NA 50% Human Human -DTXSID9020081 Css NA 5.78 mg/L PBTK NA 95% Human Human +DTXSID9020081 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human +DTXSID9020081 Css NA 3.768 mg/L 3compartmentss NA 95% Human Human +DTXSID9020081 Css NA 1.668 mg/L PBTK NA 50% Human Human +DTXSID9020081 Css NA 5.652 mg/L PBTK NA 95% Human Human DTXSID9020081 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID9020081 Fup 0.39 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human DTXSID9020081 Vd NA 1.197 L/kg 1compartment NA NA Rat Human DTXSID9020081 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9020081 TK.Half.Life NA 7.171 hours 1compartment NA NA Rat Human -DTXSID9020081 Css NA 0.3518 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020081 Css NA 1.555 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020081 Css NA 0.4506 mg/L PBTK NA 50% Rat Human -DTXSID9020081 Css NA 1.254 mg/L PBTK NA 95% Rat Human -DTXSID9020087 Clint NA 81.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020087 Fup NA 0.168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020087 Vd NA 2.279 L/kg 1compartment NA NA Human Human -DTXSID9020087 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020087 TK.Half.Life NA 2.925 hours 1compartment NA NA Human Human -DTXSID9020087 Css NA 0.06302 mg/L 3compartmentss NA 50% Human Human -DTXSID9020087 Css NA 0.4203 mg/L 3compartmentss NA 95% Human Human -DTXSID9020087 Css NA 0.04488 mg/L PBTK NA 50% Human Human -DTXSID9020087 Css NA 0.2873 mg/L PBTK NA 95% Human Human -DTXSID9020087 Clint NA 81.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020087 Fup NA 0.168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020087 Vd NA 1.737 L/kg 1compartment NA NA Rat Human -DTXSID9020087 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020087 TK.Half.Life NA 0.9298 hours 1compartment NA NA Rat Human -DTXSID9020087 Css NA 0.03502 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020087 Css NA 0.1932 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020087 Css NA 0.02399 mg/L PBTK NA 50% Rat Human -DTXSID9020087 Css NA 0.1286 mg/L PBTK NA 95% Rat Human +DTXSID9020081 Css NA 0.06742 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020081 Css NA 0.196 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020081 Css NA 0.1047 mg/L PBTK NA 50% Rat Human +DTXSID9020081 Css NA 0.3043 mg/L PBTK NA 95% Rat Human DTXSID9020089 Clint 22.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID9020089 Fup NA 0.0403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020089 Vd NA 2.493 L/kg 1compartment NA NA Human Human -DTXSID9020089 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9020089 TK.Half.Life NA 19.65 hours 1compartment NA NA Human Human -DTXSID9020089 Css NA 1.065 mg/L 3compartmentss NA 50% Human Human -DTXSID9020089 Css NA 7.753 mg/L 3compartmentss NA 95% Human Human -DTXSID9020089 Css NA 0.7132 mg/L PBTK NA 50% Human Human -DTXSID9020089 Css NA 4.97 mg/L PBTK NA 95% Human Human +DTXSID9020089 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020089 Vd NA 1.964 L/kg 1compartment NA NA Human Human +DTXSID9020089 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9020089 TK.Half.Life NA 21.76 hours 1compartment NA NA Human Human +DTXSID9020089 Css NA 1.649 mg/L 3compartmentss NA 50% Human Human +DTXSID9020089 Css NA 14.01 mg/L 3compartmentss NA 95% Human Human +DTXSID9020089 Css NA 1.053 mg/L PBTK NA 50% Human Human +DTXSID9020089 Css NA 8.695 mg/L PBTK NA 95% Human Human DTXSID9020089 Clint 22.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID9020089 Fup NA 0.0403 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020089 Vd NA 1.866 L/kg 1compartment NA NA Rat Human +DTXSID9020089 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020089 Vd NA 1.458 L/kg 1compartment NA NA Rat Human DTXSID9020089 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9020089 TK.Half.Life NA 4.976 hours 1compartment NA NA Rat Human -DTXSID9020089 Css NA 0.5982 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020089 Css NA 3.419 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020089 Css NA 0.3793 mg/L PBTK NA 50% Rat Human -DTXSID9020089 Css NA 2.092 mg/L PBTK NA 95% Rat Human -DTXSID9020110 Clint NA 39.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020110 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020110 Vd NA 2.935 L/kg 1compartment NA NA Human Human +DTXSID9020089 TK.Half.Life NA 7.097 hours 1compartment NA NA Rat Human +DTXSID9020089 Css NA 0.2148 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020089 Css NA 1.499 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020089 Css NA 0.1344 mg/L PBTK NA 50% Rat Human +DTXSID9020089 Css NA 0.8975 mg/L PBTK NA 95% Rat Human +DTXSID9020110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020110 Fup 0.0267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020110 Vd NA 3.15 L/kg 1compartment NA NA Human Human DTXSID9020110 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020110 TK.Half.Life NA 6.424 hours 1compartment NA NA Human Human -DTXSID9020110 Css NA 0.1976 mg/L 3compartmentss NA 50% Human Human -DTXSID9020110 Css NA 1.42 mg/L 3compartmentss NA 95% Human Human -DTXSID9020110 Css NA 0.1384 mg/L PBTK NA 50% Human Human -DTXSID9020110 Css NA 0.9393 mg/L PBTK NA 95% Human Human -DTXSID9020110 Clint NA 39.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020110 Fup NA 0.0165 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020110 Vd NA 2.281 L/kg 1compartment NA NA Rat Human +DTXSID9020110 TK.Half.Life NA 9.975 hours 1compartment NA NA Human Human +DTXSID9020110 Css NA 0.2979 mg/L 3compartmentss NA 50% Human Human +DTXSID9020110 Css NA 2.162 mg/L 3compartmentss NA 95% Human Human +DTXSID9020110 Css NA 0.2126 mg/L PBTK NA 50% Human Human +DTXSID9020110 Css NA 1.486 mg/L PBTK NA 95% Human Human +DTXSID9020110 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020110 Fup 0.0267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020110 Vd NA 2.43 L/kg 1compartment NA NA Rat Human DTXSID9020110 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020110 TK.Half.Life NA 1.69 hours 1compartment NA NA Rat Human -DTXSID9020110 Css NA 0.109 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020110 Css NA 0.6606 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020110 Css NA 0.0734 mg/L PBTK NA 50% Rat Human -DTXSID9020110 Css NA 0.42 mg/L PBTK NA 95% Rat Human +DTXSID9020110 TK.Half.Life NA 2.096 hours 1compartment NA NA Rat Human +DTXSID9020110 Css NA 0.03881 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020110 Css NA 0.2385 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020110 Css NA 0.02756 mg/L PBTK NA 50% Rat Human +DTXSID9020110 Css NA 0.1609 mg/L PBTK NA 95% Rat Human DTXSID9020112 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9020112 Fup 0.1237 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9020112 Vd NA 1.501 L/kg 1compartment NA NA Human Human DTXSID9020112 Days.Css NA 20 Days PBTK NA NA Human Human DTXSID9020112 TK.Half.Life NA 107.4 hours 1compartment NA NA Human Human -DTXSID9020112 Css NA 9.742 mg/L 3compartmentss NA 50% Human Human -DTXSID9020112 Css NA 41.08 mg/L 3compartmentss NA 95% Human Human -DTXSID9020112 Css NA 6.579 mg/L PBTK NA 50% Human Human -DTXSID9020112 Css NA 24.9 mg/L PBTK NA 95% Human Human +DTXSID9020112 Css NA 9.507 mg/L 3compartmentss NA 50% Human Human +DTXSID9020112 Css NA 39.22 mg/L 3compartmentss NA 95% Human Human +DTXSID9020112 Css NA 6.418 mg/L PBTK NA 50% Human Human +DTXSID9020112 Css NA 23.93 mg/L PBTK NA 95% Human Human DTXSID9020112 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9020112 Fup 0.1237 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9020112 Vd NA 1.158 L/kg 1compartment NA NA Rat Human -DTXSID9020112 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9020112 TK.Half.Life NA 22.46 hours 1compartment NA NA Rat Human -DTXSID9020112 Css NA 2.686 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020112 Css NA 9.703 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020112 Css NA 1.717 mg/L PBTK NA 50% Rat Human -DTXSID9020112 Css NA 5.538 mg/L PBTK NA 95% Rat Human +DTXSID9020112 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9020112 TK.Half.Life NA 1.943 hours 1compartment NA NA Rat Human +DTXSID9020112 Css NA 0.0477 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020112 Css NA 0.2598 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020112 Css NA 0.03152 mg/L PBTK NA 50% Rat Human +DTXSID9020112 Css NA 0.1595 mg/L PBTK NA 95% Rat Human DTXSID9020114 Clint 8.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020114 Fup 0.107 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9020114 Vd NA 1.477 L/kg 1compartment NA NA Human Human +DTXSID9020114 Vd NA 1.308 L/kg 1compartment NA NA Human Human DTXSID9020114 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020114 TK.Half.Life NA 5.131 hours 1compartment NA NA Human Human -DTXSID9020114 Css NA 0.3028 mg/L 3compartmentss NA 50% Human Human -DTXSID9020114 Css NA 2.049 mg/L 3compartmentss NA 95% Human Human -DTXSID9020114 Css NA 0.2499 mg/L PBTK NA 50% Human Human -DTXSID9020114 Css NA 1.486 mg/L PBTK NA 95% Human Human +DTXSID9020114 TK.Half.Life NA 4.912 hours 1compartment NA NA Human Human +DTXSID9020114 Css NA 0.3358 mg/L 3compartmentss NA 50% Human Human +DTXSID9020114 Css NA 2.165 mg/L 3compartmentss NA 95% Human Human +DTXSID9020114 Css NA 0.2631 mg/L PBTK NA 50% Human Human +DTXSID9020114 Css NA 1.559 mg/L PBTK NA 95% Human Human DTXSID9020114 Clint 8.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020114 Fup 0.107 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9020114 Vd NA 1.443 L/kg 1compartment NA NA Rat Human +DTXSID9020114 Vd NA 1.275 L/kg 1compartment NA NA Rat Human DTXSID9020114 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020114 TK.Half.Life NA 3.107 hours 1compartment NA NA Rat Human -DTXSID9020114 Css NA 0.1597 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020114 Css NA 0.7933 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020114 Css NA 0.1273 mg/L PBTK NA 50% Rat Human -DTXSID9020114 Css NA 0.549 mg/L PBTK NA 95% Rat Human -DTXSID9020116 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020116 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020116 Vd NA 1.211 L/kg 1compartment NA NA Human Human +DTXSID9020114 TK.Half.Life NA 2.967 hours 1compartment NA NA Rat Human +DTXSID9020114 Css NA 0.04092 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020114 Css NA 0.1957 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020114 Css NA 0.032 mg/L PBTK NA 50% Rat Human +DTXSID9020114 Css NA 0.137 mg/L PBTK NA 95% Rat Human +DTXSID9020116 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020116 Fup 0.907 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020116 Vd NA 1.137 L/kg 1compartment NA NA Human Human DTXSID9020116 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020116 TK.Half.Life NA 7.837 hours 1compartment NA NA Human Human -DTXSID9020116 Css NA 0.767 mg/L 3compartmentss NA 50% Human Human -DTXSID9020116 Css NA 5.395 mg/L 3compartmentss NA 95% Human Human -DTXSID9020116 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID9020116 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID9020116 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020116 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020116 Vd NA 1.26 L/kg 1compartment NA NA Rat Human +DTXSID9020116 TK.Half.Life NA 8.111 hours 1compartment NA NA Human Human +DTXSID9020116 Css NA 0.4706 mg/L 3compartmentss NA 50% Human Human +DTXSID9020116 Css NA 2.843 mg/L 3compartmentss NA 95% Human Human +DTXSID9020116 Css NA 0.4178 mg/L PBTK NA 50% Human Human +DTXSID9020116 Css NA 1.917 mg/L PBTK NA 95% Human Human +DTXSID9020116 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020116 Fup 0.907 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020116 Vd NA 1.183 L/kg 1compartment NA NA Rat Human DTXSID9020116 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020116 TK.Half.Life NA 2.778 hours 1compartment NA NA Rat Human -DTXSID9020116 Css NA 0.1908 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020116 Css NA 1.295 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020116 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID9020116 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID9020118 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020118 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020118 Vd NA 0.7165 L/kg 1compartment NA NA Human Human +DTXSID9020116 TK.Half.Life NA 2.876 hours 1compartment NA NA Rat Human +DTXSID9020116 Css NA 0.00241 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020116 Css NA 0.01567 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020116 Css NA 0.002092 mg/L PBTK NA 50% Rat Human +DTXSID9020116 Css NA 0.0103 mg/L PBTK NA 95% Rat Human +DTXSID9020118 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020118 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020118 Vd NA 0.6291 L/kg 1compartment NA NA Human Human DTXSID9020118 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020118 TK.Half.Life NA 4.636 hours 1compartment NA NA Human Human -DTXSID9020118 Css NA 0.8432 mg/L 3compartmentss NA 50% Human Human -DTXSID9020118 Css NA 5.536 mg/L 3compartmentss NA 95% Human Human -DTXSID9020118 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID9020118 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID9020118 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020118 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020118 Vd NA 0.7633 L/kg 1compartment NA NA Rat Human +DTXSID9020118 TK.Half.Life NA 5.071 hours 1compartment NA NA Human Human +DTXSID9020118 Css NA 0.992 mg/L 3compartmentss NA 50% Human Human +DTXSID9020118 Css NA 5.618 mg/L 3compartmentss NA 95% Human Human +DTXSID9020118 Css NA 0.7918 mg/L PBTK NA 50% Human Human +DTXSID9020118 Css NA 3.586 mg/L PBTK NA 95% Human Human +DTXSID9020118 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020118 Fup 0.803 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020118 Vd NA 0.6696 L/kg 1compartment NA NA Rat Human DTXSID9020118 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020118 TK.Half.Life NA 1.683 hours 1compartment NA NA Rat Human -DTXSID9020118 Css NA 0.2119 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020118 Css NA 1.314 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020118 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID9020118 Css NA 0.7874 mg/L PBTK NA 95% Rat Human +DTXSID9020118 TK.Half.Life NA 1.839 hours 1compartment NA NA Rat Human +DTXSID9020118 Css NA 0.05864 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020118 Css NA 0.3295 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020118 Css NA 0.04692 mg/L PBTK NA 50% Rat Human +DTXSID9020118 Css NA 0.2027 mg/L PBTK NA 95% Rat Human DTXSID9020160 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9020160 Fup NA 0.0039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020160 Vd NA 4.114 L/kg 1compartment NA NA Human Human +DTXSID9020160 Fup 0.00777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020160 Vd NA 3.102 L/kg 1compartment NA NA Human Human DTXSID9020160 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID9020160 TK.Half.Life NA 201300 hours 1compartment NA NA Human Human -DTXSID9020160 Css NA 5066 mg/L 3compartmentss NA 50% Human Human -DTXSID9020160 Css NA 11240 mg/L 3compartmentss NA 95% Human Human -DTXSID9020160 Css NA 3814 mg/L PBTK NA 50% Human Human -DTXSID9020160 Css NA 8069 mg/L PBTK NA 95% Human Human +DTXSID9020160 TK.Half.Life NA 149100 hours 1compartment NA NA Human Human +DTXSID9020160 Css NA 5174 mg/L 3compartmentss NA 50% Human Human +DTXSID9020160 Css NA 11740 mg/L 3compartmentss NA 95% Human Human +DTXSID9020160 Css NA 3590 mg/L PBTK NA 50% Human Human +DTXSID9020160 Css NA 7819 mg/L PBTK NA 95% Human Human DTXSID9020160 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9020160 Fup NA 0.0039 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020160 Vd NA 3.116 L/kg 1compartment NA NA Rat Human -DTXSID9020160 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID9020160 TK.Half.Life NA 13720 hours 1compartment NA NA Rat Human -DTXSID9020160 Css NA 1410 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020160 Css NA 1939 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020160 Css NA 1023 mg/L PBTK NA 50% Rat Human -DTXSID9020160 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID9020164 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020164 Fup NA 0.615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020164 Vd NA 1.059 L/kg 1compartment NA NA Human Human -DTXSID9020164 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9020164 TK.Half.Life NA 11.71 hours 1compartment NA NA Human Human -DTXSID9020164 Css NA 1.185 mg/L 3compartmentss NA 50% Human Human -DTXSID9020164 Css NA 7.953 mg/L 3compartmentss NA 95% Human Human -DTXSID9020164 Css NA 1.006 mg/L PBTK NA 50% Human Human -DTXSID9020164 Css NA 5.054 mg/L PBTK NA 95% Human Human -DTXSID9020164 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020164 Fup NA 0.615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020164 Vd NA 0.9815 L/kg 1compartment NA NA Rat Human +DTXSID9020160 Fup 0.00777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020160 Vd NA 2.323 L/kg 1compartment NA NA Rat Human +DTXSID9020160 Days.Css NA 8526 Days PBTK NA NA Rat Human +DTXSID9020160 TK.Half.Life NA 9573 hours 1compartment NA NA Rat Human +DTXSID9020160 Css NA 338.7 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020160 Css NA 474.6 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020160 Css NA 232.8 mg/L PBTK NA 50% Rat Human +DTXSID9020160 Css NA 311.1 mg/L PBTK NA 95% Rat Human +DTXSID9020164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020164 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020164 Vd NA 0.9903 L/kg 1compartment NA NA Human Human +DTXSID9020164 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9020164 TK.Half.Life NA 0.9233 hours 1compartment NA NA Human Human +DTXSID9020164 Css NA 0.03481 mg/L 3compartmentss NA 50% Human Human +DTXSID9020164 Css NA 0.3535 mg/L 3compartmentss NA 95% Human Human +DTXSID9020164 Css NA 0.02844 mg/L PBTK NA 50% Human Human +DTXSID9020164 Css NA 0.2447 mg/L PBTK NA 95% Human Human +DTXSID9020164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020164 Fup 0.549 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020164 Vd NA 0.9169 L/kg 1compartment NA NA Rat Human DTXSID9020164 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020164 TK.Half.Life NA 3.562 hours 1compartment NA NA Rat Human -DTXSID9020164 Css NA 0.3102 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020164 Css NA 2.007 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020164 Css NA 0.2542 mg/L PBTK NA 50% Rat Human -DTXSID9020164 Css NA 1.203 mg/L PBTK NA 95% Rat Human -DTXSID9020166 Clint NA 345.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020166 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020166 Vd NA 541400 L/kg 1compartment NA NA Human Human -DTXSID9020166 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID9020166 TK.Half.Life NA 1009000 hours 1compartment NA NA Human Human -DTXSID9020166 Css NA 1.397e-06 mg/L 3compartmentss NA 50% Human Human -DTXSID9020166 Css NA 8.723e-06 mg/L 3compartmentss NA 95% Human Human -DTXSID9020166 Css NA 0.1551 mg/L PBTK NA 50% Human Human -DTXSID9020166 Css NA 0.8823 mg/L PBTK NA 95% Human Human -DTXSID9020166 Clint NA 345.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020166 Fup NA 0.0077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020166 Vd NA 516600 L/kg 1compartment NA NA Rat Human -DTXSID9020166 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID9020166 TK.Half.Life NA 170000 hours 1compartment NA NA Rat Human -DTXSID9020166 Css NA 7.19e-07 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020166 Css NA 3.07e-06 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020166 Css NA 0.08397 mg/L PBTK NA 50% Rat Human -DTXSID9020166 Css NA 0.3597 mg/L PBTK NA 95% Rat Human -DTXSID9020168 Clint NA 1.293 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020168 Fup NA 0.6211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020168 Vd NA 1.218 L/kg 1compartment NA NA Human Human +DTXSID9020164 TK.Half.Life NA 0.4247 hours 1compartment NA NA Rat Human +DTXSID9020164 Css NA 0.004233 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020164 Css NA 0.03688 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020164 Css NA 0.003528 mg/L PBTK NA 50% Rat Human +DTXSID9020164 Css NA 0.02529 mg/L PBTK NA 95% Rat Human +DTXSID9020168 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020168 Fup 0.529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020168 Vd NA 1.11 L/kg 1compartment NA NA Human Human DTXSID9020168 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020168 TK.Half.Life NA 4.668 hours 1compartment NA NA Human Human -DTXSID9020168 Css NA 0.3796 mg/L 3compartmentss NA 50% Human Human -DTXSID9020168 Css NA 2.808 mg/L 3compartmentss NA 95% Human Human -DTXSID9020168 Css NA 0.3292 mg/L PBTK NA 50% Human Human -DTXSID9020168 Css NA 1.856 mg/L PBTK NA 95% Human Human -DTXSID9020168 Clint NA 1.293 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020168 Fup NA 0.6211 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020168 Vd NA 1.098 L/kg 1compartment NA NA Rat Human +DTXSID9020168 TK.Half.Life NA 1.056 hours 1compartment NA NA Human Human +DTXSID9020168 Css NA 0.02937 mg/L 3compartmentss NA 50% Human Human +DTXSID9020168 Css NA 0.2989 mg/L 3compartmentss NA 95% Human Human +DTXSID9020168 Css NA 0.02406 mg/L PBTK NA 50% Human Human +DTXSID9020168 Css NA 0.2143 mg/L PBTK NA 95% Human Human +DTXSID9020168 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020168 Fup 0.529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020168 Vd NA 0.9986 L/kg 1compartment NA NA Rat Human DTXSID9020168 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020168 TK.Half.Life NA 2.003 hours 1compartment NA NA Rat Human -DTXSID9020168 Css NA 0.154 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020168 Css NA 1.051 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020168 Css NA 0.1293 mg/L PBTK NA 50% Rat Human -DTXSID9020168 Css NA 0.6386 mg/L PBTK NA 95% Rat Human -DTXSID9020241 Clint NA 6.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020241 Fup NA 0.059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020241 Vd NA 2.037 L/kg 1compartment NA NA Human Human -DTXSID9020241 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9020241 TK.Half.Life NA 26.97 hours 1compartment NA NA Human Human -DTXSID9020241 Css NA 1.908 mg/L 3compartmentss NA 50% Human Human -DTXSID9020241 Css NA 11.66 mg/L 3compartmentss NA 95% Human Human -DTXSID9020241 Css NA 1.264 mg/L PBTK NA 50% Human Human -DTXSID9020241 Css NA 7.314 mg/L PBTK NA 95% Human Human -DTXSID9020241 Clint NA 6.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020241 Fup NA 0.059 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020241 Vd NA 1.529 L/kg 1compartment NA NA Rat Human -DTXSID9020241 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9020241 TK.Half.Life NA 8.358 hours 1compartment NA NA Rat Human -DTXSID9020241 Css NA 1.027 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020241 Css NA 4.586 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020241 Css NA 0.6404 mg/L PBTK NA 50% Rat Human -DTXSID9020241 Css NA 2.733 mg/L PBTK NA 95% Rat Human -DTXSID9020243 Clint NA 2.683 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020243 Fup NA 0.1204 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020243 Vd NA 1.366 L/kg 1compartment NA NA Human Human -DTXSID9020243 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9020243 TK.Half.Life NA 16.36 hours 1compartment NA NA Human Human -DTXSID9020243 Css NA 1.688 mg/L 3compartmentss NA 50% Human Human -DTXSID9020243 Css NA 9.559 mg/L 3compartmentss NA 95% Human Human -DTXSID9020243 Css NA 1.133 mg/L PBTK NA 50% Human Human -DTXSID9020243 Css NA 5.957 mg/L PBTK NA 95% Human Human -DTXSID9020243 Clint NA 2.683 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020243 Fup NA 0.1204 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020243 Vd NA 1.059 L/kg 1compartment NA NA Rat Human +DTXSID9020168 TK.Half.Life NA 0.4712 hours 1compartment NA NA Rat Human +DTXSID9020168 Css NA 0.001042 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020168 Css NA 0.01225 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020168 Css NA 0.000842 mg/L PBTK NA 50% Rat Human +DTXSID9020168 Css NA 0.008533 mg/L PBTK NA 95% Rat Human +DTXSID9020241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020241 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020241 Vd NA 1.994 L/kg 1compartment NA NA Human Human +DTXSID9020241 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9020241 TK.Half.Life NA 6.319 hours 1compartment NA NA Human Human +DTXSID9020241 Css NA 0.3438 mg/L 3compartmentss NA 50% Human Human +DTXSID9020241 Css NA 2.428 mg/L 3compartmentss NA 95% Human Human +DTXSID9020241 Css NA 0.233 mg/L PBTK NA 50% Human Human +DTXSID9020241 Css NA 1.561 mg/L PBTK NA 95% Human Human +DTXSID9020241 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020241 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020241 Vd NA 1.512 L/kg 1compartment NA NA Rat Human +DTXSID9020241 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9020241 TK.Half.Life NA 2.107 hours 1compartment NA NA Rat Human +DTXSID9020241 Css NA 0.04363 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020241 Css NA 0.2509 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020241 Css NA 0.02905 mg/L PBTK NA 50% Rat Human +DTXSID9020241 Css NA 0.1584 mg/L PBTK NA 95% Rat Human +DTXSID9020243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020243 Fup 0.097 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020243 Vd NA 1.592 L/kg 1compartment NA NA Human Human +DTXSID9020243 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9020243 TK.Half.Life NA 4.731 hours 1compartment NA NA Human Human +DTXSID9020243 Css NA 0.3268 mg/L 3compartmentss NA 50% Human Human +DTXSID9020243 Css NA 2.47 mg/L 3compartmentss NA 95% Human Human +DTXSID9020243 Css NA 0.2157 mg/L PBTK NA 50% Human Human +DTXSID9020243 Css NA 1.554 mg/L PBTK NA 95% Human Human +DTXSID9020243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020243 Fup 0.097 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020243 Vd NA 1.215 L/kg 1compartment NA NA Rat Human DTXSID9020243 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020243 TK.Half.Life NA 6.172 hours 1compartment NA NA Rat Human -DTXSID9020243 Css NA 0.818 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020243 Css NA 3.493 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020243 Css NA 0.519 mg/L PBTK NA 50% Rat Human -DTXSID9020243 Css NA 1.996 mg/L PBTK NA 95% Rat Human -DTXSID9020245 Clint NA 1.345 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020245 Fup NA 0.9472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020245 Vd NA 0.9471 L/kg 1compartment NA NA Human Human +DTXSID9020243 TK.Half.Life NA 1.788 hours 1compartment NA NA Rat Human +DTXSID9020243 Css NA 0.04204 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020243 Css NA 0.2498 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020243 Css NA 0.02747 mg/L PBTK NA 50% Rat Human +DTXSID9020243 Css NA 0.1551 mg/L PBTK NA 95% Rat Human +DTXSID9020245 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020245 Fup 0.576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020245 Vd NA 0.701 L/kg 1compartment NA NA Human Human DTXSID9020245 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020245 TK.Half.Life NA 2.272 hours 1compartment NA NA Human Human -DTXSID9020245 Css NA 0.258 mg/L 3compartmentss NA 50% Human Human -DTXSID9020245 Css NA 1.105 mg/L 3compartmentss NA 95% Human Human -DTXSID9020245 Css NA 0.2227 mg/L PBTK NA 50% Human Human -DTXSID9020245 Css NA 0.8345 mg/L PBTK NA 95% Human Human -DTXSID9020245 Clint NA 1.345 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020245 Fup NA 0.9472 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020245 Vd NA 0.9535 L/kg 1compartment NA NA Rat Human +DTXSID9020245 TK.Half.Life NA 7.917 hours 1compartment NA NA Human Human +DTXSID9020245 Css NA 1.249 mg/L 3compartmentss NA 50% Human Human +DTXSID9020245 Css NA 8.557 mg/L 3compartmentss NA 95% Human Human +DTXSID9020245 Css NA 0.9926 mg/L PBTK NA 50% Human Human +DTXSID9020245 Css NA 5.402 mg/L PBTK NA 95% Human Human +DTXSID9020245 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020245 Fup 0.576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020245 Vd NA 0.7037 L/kg 1compartment NA NA Rat Human DTXSID9020245 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020245 TK.Half.Life NA 1.131 hours 1compartment NA NA Rat Human -DTXSID9020245 Css NA 0.1019 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020245 Css NA 0.3641 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020245 Css NA 0.08811 mg/L PBTK NA 50% Rat Human -DTXSID9020245 Css NA 0.2485 mg/L PBTK NA 95% Rat Human +DTXSID9020245 TK.Half.Life NA 2.698 hours 1compartment NA NA Rat Human +DTXSID9020245 Css NA 0.07606 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020245 Css NA 0.4801 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020245 Css NA 0.06016 mg/L PBTK NA 50% Rat Human +DTXSID9020245 Css NA 0.2912 mg/L PBTK NA 95% Rat Human DTXSID9020247 Clint 27.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9020247 Fup 0.6922 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID9020247 Vd NA 2.359 L/kg 1compartment NA NA Human Human +DTXSID9020247 Vd NA 2.256 L/kg 1compartment NA NA Human Human DTXSID9020247 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020247 TK.Half.Life NA 2.29 hours 1compartment NA NA Human Human -DTXSID9020247 Css NA 0.04762 mg/L 3compartmentss NA 50% Human Human -DTXSID9020247 Css NA 0.3906 mg/L 3compartmentss NA 95% Human Human -DTXSID9020247 Css NA 0.0338 mg/L PBTK NA 50% Human Human -DTXSID9020247 Css NA 0.2567 mg/L PBTK NA 95% Human Human +DTXSID9020247 TK.Half.Life NA 2.153 hours 1compartment NA NA Human Human +DTXSID9020247 Css NA 0.03613 mg/L 3compartmentss NA 50% Human Human +DTXSID9020247 Css NA 0.2843 mg/L 3compartmentss NA 95% Human Human +DTXSID9020247 Css NA 0.03064 mg/L PBTK NA 50% Human Human +DTXSID9020247 Css NA 0.242 mg/L PBTK NA 95% Human Human DTXSID9020247 Clint 14.97 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID9020247 Fup 0.3753 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID9020247 Vd NA 1.491 L/kg 1compartment NA NA Rat Rat +DTXSID9020247 Vd 44 1.409 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID9020247 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID9020247 TK.Half.Life NA 1.045 hours 1compartment NA NA Rat Rat -DTXSID9020247 Css NA 0.05821 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9020247 Css NA 0.2964 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9020247 Css NA 0.04225 mg/L PBTK NA 50% Rat Rat -DTXSID9020247 Css NA 0.199 mg/L PBTK NA 95% Rat Rat +DTXSID9020247 TK.Half.Life 0.54 0.9835 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID9020247 Css 0.00074 0.0108 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID9020247 Css 0.00074 0.05125 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID9020247 Css 0.00074 0.00953 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID9020247 Css 0.00074 0.04522 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat DTXSID9020249 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9020249 Fup 0.4213 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9020249 Vd NA 0.8914 L/kg 1compartment NA NA Human Human +DTXSID9020249 Vd NA 0.6598 L/kg 1compartment NA NA Human Human DTXSID9020249 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9020249 TK.Half.Life NA 14.6 hours 1compartment NA NA Human Human -DTXSID9020249 Css NA 1.797 mg/L 3compartmentss NA 50% Human Human -DTXSID9020249 Css NA 7.891 mg/L 3compartmentss NA 95% Human Human -DTXSID9020249 Css NA 1.372 mg/L PBTK NA 50% Human Human -DTXSID9020249 Css NA 5.138 mg/L PBTK NA 95% Human Human +DTXSID9020249 TK.Half.Life NA 10.37 hours 1compartment NA NA Human Human +DTXSID9020249 Css NA 1.692 mg/L 3compartmentss NA 50% Human Human +DTXSID9020249 Css NA 7.671 mg/L 3compartmentss NA 95% Human Human +DTXSID9020249 Css NA 1.26 mg/L PBTK NA 50% Human Human +DTXSID9020249 Css NA 4.892 mg/L PBTK NA 95% Human Human DTXSID9020249 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9020249 Fup 0.4213 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID9020249 Vd NA 0.778 L/kg 1compartment NA NA Rat Human +DTXSID9020249 Vd NA 0.6087 L/kg 1compartment NA NA Rat Human DTXSID9020249 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020249 TK.Half.Life NA 4.136 hours 1compartment NA NA Rat Human -DTXSID9020249 Css NA 0.4848 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020249 Css NA 1.811 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020249 Css NA 0.3549 mg/L PBTK NA 50% Rat Human -DTXSID9020249 Css NA 1.091 mg/L PBTK NA 95% Rat Human -DTXSID9020293 Clint NA 10.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020293 Fup NA 0.3505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020293 Vd NA 1.973 L/kg 1compartment NA NA Human Human +DTXSID9020249 TK.Half.Life NA 3.203 hours 1compartment NA NA Rat Human +DTXSID9020249 Css NA 0.1084 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020249 Css NA 0.4195 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020249 Css NA 0.07974 mg/L PBTK NA 50% Rat Human +DTXSID9020249 Css NA 0.2576 mg/L PBTK NA 95% Rat Human +DTXSID9020293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020293 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020293 Vd NA 0.9976 L/kg 1compartment NA NA Human Human DTXSID9020293 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020293 TK.Half.Life NA 4.156 hours 1compartment NA NA Human Human -DTXSID9020293 Css NA 0.1666 mg/L 3compartmentss NA 50% Human Human -DTXSID9020293 Css NA 1.039 mg/L 3compartmentss NA 95% Human Human -DTXSID9020293 Css NA 0.1307 mg/L PBTK NA 50% Human Human -DTXSID9020293 Css NA 0.7584 mg/L PBTK NA 95% Human Human -DTXSID9020293 Clint NA 10.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020293 Fup NA 0.3505 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020293 Vd NA 1.562 L/kg 1compartment NA NA Rat Human +DTXSID9020293 TK.Half.Life NA 1.602 hours 1compartment NA NA Human Human +DTXSID9020293 Css NA 0.1009 mg/L 3compartmentss NA 50% Human Human +DTXSID9020293 Css NA 0.7225 mg/L 3compartmentss NA 95% Human Human +DTXSID9020293 Css NA 0.07162 mg/L PBTK NA 50% Human Human +DTXSID9020293 Css NA 0.4746 mg/L PBTK NA 95% Human Human +DTXSID9020293 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020293 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020293 Vd NA 0.829 L/kg 1compartment NA NA Rat Human DTXSID9020293 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020293 TK.Half.Life NA 1.471 hours 1compartment NA NA Rat Human -DTXSID9020293 Css NA 0.08757 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020293 Css NA 0.4095 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020293 Css NA 0.0662 mg/L PBTK NA 50% Rat Human -DTXSID9020293 Css NA 0.2781 mg/L PBTK NA 95% Rat Human +DTXSID9020293 TK.Half.Life NA 0.7063 hours 1compartment NA NA Rat Human +DTXSID9020293 Css NA 0.01287 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020293 Css NA 0.06975 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020293 Css NA 0.008974 mg/L PBTK NA 50% Rat Human +DTXSID9020293 Css NA 0.04625 mg/L PBTK NA 95% Rat Human DTXSID9020295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020295 Fup 0.264 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020295 Vd NA 1.112 L/kg 1compartment NA NA Human Human DTXSID9020295 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID9020295 TK.Half.Life NA 30.79 hours 1compartment NA NA Human Human -DTXSID9020295 Css NA 2.897 mg/L 3compartmentss NA 50% Human Human -DTXSID9020295 Css NA 8.806 mg/L 3compartmentss NA 95% Human Human -DTXSID9020295 Css NA 2.137 mg/L PBTK NA 50% Human Human -DTXSID9020295 Css NA 5.912 mg/L PBTK NA 95% Human Human +DTXSID9020295 Css NA 2.813 mg/L 3compartmentss NA 50% Human Human +DTXSID9020295 Css NA 8.401 mg/L 3compartmentss NA 95% Human Human +DTXSID9020295 Css NA 2.083 mg/L PBTK NA 50% Human Human +DTXSID9020295 Css NA 5.652 mg/L PBTK NA 95% Human Human DTXSID9020295 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020295 Fup 0.264 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020295 Vd NA 0.927 L/kg 1compartment NA NA Rat Human DTXSID9020295 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9020295 TK.Half.Life NA 7.981 hours 1compartment NA NA Rat Human -DTXSID9020295 Css NA 0.8106 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020295 Css NA 1.913 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020295 Css NA 0.574 mg/L PBTK NA 50% Rat Human -DTXSID9020295 Css NA 1.189 mg/L PBTK NA 95% Rat Human +DTXSID9020295 Css NA 0.183 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020295 Css NA 0.4272 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020295 Css NA 0.1344 mg/L PBTK NA 50% Rat Human +DTXSID9020295 Css NA 0.2754 mg/L PBTK NA 95% Rat Human DTXSID9020299 Clint 477 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9020299 Fup NA 0.0182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020299 Vd NA 2.864 L/kg 1compartment NA NA Human Human +DTXSID9020299 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020299 Vd NA 2.707 L/kg 1compartment NA NA Human Human DTXSID9020299 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020299 TK.Half.Life NA 4.53 hours 1compartment NA NA Human Human -DTXSID9020299 Css NA 0.1057 mg/L 3compartmentss NA 50% Human Human -DTXSID9020299 Css NA 0.8391 mg/L 3compartmentss NA 95% Human Human -DTXSID9020299 Css NA 0.0714 mg/L PBTK NA 50% Human Human -DTXSID9020299 Css NA 0.5513 mg/L PBTK NA 95% Human Human +DTXSID9020299 TK.Half.Life NA 4.495 hours 1compartment NA NA Human Human +DTXSID9020299 Css NA 0.115 mg/L 3compartmentss NA 50% Human Human +DTXSID9020299 Css NA 0.9673 mg/L 3compartmentss NA 95% Human Human +DTXSID9020299 Css NA 0.07689 mg/L PBTK NA 50% Human Human +DTXSID9020299 Css NA 0.6301 mg/L PBTK NA 95% Human Human DTXSID9020299 Clint 477 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9020299 Fup NA 0.0182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020299 Vd NA 2.141 L/kg 1compartment NA NA Rat Human +DTXSID9020299 Fup 0.0109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020299 Vd NA 2.02 L/kg 1compartment NA NA Rat Human DTXSID9020299 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020299 TK.Half.Life NA 1.163 hours 1compartment NA NA Rat Human -DTXSID9020299 Css NA 0.06014 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020299 Css NA 0.3737 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020299 Css NA 0.03901 mg/L PBTK NA 50% Rat Human -DTXSID9020299 Css NA 0.2336 mg/L PBTK NA 95% Rat Human -DTXSID9020322 Clint NA 10.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9020299 TK.Half.Life NA 1.203 hours 1compartment NA NA Rat Human +DTXSID9020299 Css NA 0.01542 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020299 Css NA 0.1133 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020299 Css NA 0.01018 mg/L PBTK NA 50% Rat Human +DTXSID9020299 Css NA 0.07081 mg/L PBTK NA 95% Rat Human +DTXSID9020322 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9020322 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9020322 Vd NA 0.2072 L/kg 1compartment NA NA Human Human DTXSID9020322 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020322 TK.Half.Life NA 2.573 hours 1compartment NA NA Human Human -DTXSID9020322 Css NA 2.2 mg/L 3compartmentss NA 50% Human Human -DTXSID9020322 Css NA 19.31 mg/L 3compartmentss NA 95% Human Human -DTXSID9020322 Css NA 1.308 mg/L PBTK NA 50% Human Human -DTXSID9020322 Css NA 11.29 mg/L PBTK NA 95% Human Human -DTXSID9020322 Clint NA 10.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9020322 TK.Half.Life NA 4.101 hours 1compartment NA NA Human Human +DTXSID9020322 Css NA 3.501 mg/L 3compartmentss NA 50% Human Human +DTXSID9020322 Css NA 28.33 mg/L 3compartmentss NA 95% Human Human +DTXSID9020322 Css NA 2.07 mg/L PBTK NA 50% Human Human +DTXSID9020322 Css NA 16.78 mg/L PBTK NA 95% Human Human +DTXSID9020322 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9020322 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9020322 Vd NA 0.2027 L/kg 1compartment NA NA Rat Human DTXSID9020322 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020322 TK.Half.Life NA 1.625 hours 1compartment NA NA Rat Human -DTXSID9020322 Css NA 1.227 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020322 Css NA 8.535 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020322 Css NA 0.6772 mg/L PBTK NA 50% Rat Human -DTXSID9020322 Css NA 4.631 mg/L PBTK NA 95% Rat Human -DTXSID9020326 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020326 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020326 Vd NA 0.6447 L/kg 1compartment NA NA Human Human -DTXSID9020326 TK.Half.Life NA NA hours 1compartment NA NA Human Human -DTXSID9020326 Css NA NA mg/L 3compartmentss NA 50% Human Human -DTXSID9020326 Css NA NA mg/L 3compartmentss NA 95% Human Human -DTXSID9020326 Css NA NA mg/L PBTK NA 50% Human Human -DTXSID9020326 Css NA NA mg/L PBTK NA 95% Human Human -DTXSID9020326 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020326 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020326 Vd NA 0.7067 L/kg 1compartment NA NA Rat Human -DTXSID9020326 TK.Half.Life NA NA hours 1compartment NA NA Rat Human -DTXSID9020326 Css NA NA mg/L 3compartmentss NA 50% Rat Human -DTXSID9020326 Css NA NA mg/L 3compartmentss NA 95% Rat Human -DTXSID9020326 Css NA NA mg/L PBTK NA 50% Rat Human -DTXSID9020326 Css NA NA mg/L PBTK NA 95% Rat Human -DTXSID9020328 Clint NA 3.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020328 Fup NA 0.0331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020328 Vd NA 0.4238 L/kg 1compartment NA NA Human Human -DTXSID9020328 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9020328 TK.Half.Life NA 13.4 hours 1compartment NA NA Human Human -DTXSID9020328 Css NA 5.821 mg/L 3compartmentss NA 50% Human Human -DTXSID9020328 Css NA 40.33 mg/L 3compartmentss NA 95% Human Human -DTXSID9020328 Css NA 3.491 mg/L PBTK NA 50% Human Human -DTXSID9020328 Css NA 23.63 mg/L PBTK NA 95% Human Human -DTXSID9020328 Clint NA 3.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020328 Fup NA 0.0331 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020328 Vd NA 0.3436 L/kg 1compartment NA NA Rat Human +DTXSID9020322 TK.Half.Life NA 2.532 hours 1compartment NA NA Rat Human +DTXSID9020322 Css NA 0.4358 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020322 Css NA 2.783 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020322 Css NA 0.2489 mg/L PBTK NA 50% Rat Human +DTXSID9020322 Css NA 1.57 mg/L PBTK NA 95% Rat Human +DTXSID9020328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020328 Fup 0.0446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020328 Vd NA 0.8623 L/kg 1compartment NA NA Human Human +DTXSID9020328 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9020328 TK.Half.Life NA 4.049 hours 1compartment NA NA Human Human +DTXSID9020328 Css NA 0.6627 mg/L 3compartmentss NA 50% Human Human +DTXSID9020328 Css NA 5.545 mg/L 3compartmentss NA 95% Human Human +DTXSID9020328 Css NA 0.4106 mg/L PBTK NA 50% Human Human +DTXSID9020328 Css NA 3.339 mg/L PBTK NA 95% Human Human +DTXSID9020328 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020328 Fup 0.0446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020328 Vd NA 0.6568 L/kg 1compartment NA NA Rat Human DTXSID9020328 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020328 TK.Half.Life NA 6.377 hours 1compartment NA NA Rat Human -DTXSID9020328 Css NA 2.849 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020328 Css NA 15.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020328 Css NA 1.596 mg/L PBTK NA 50% Rat Human -DTXSID9020328 Css NA 8.218 mg/L PBTK NA 95% Rat Human +DTXSID9020328 TK.Half.Life NA 1.817 hours 1compartment NA NA Rat Human +DTXSID9020328 Css NA 0.08669 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020328 Css NA 0.5583 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020328 Css NA 0.05213 mg/L PBTK NA 50% Rat Human +DTXSID9020328 Css NA 0.3228 mg/L PBTK NA 95% Rat Human DTXSID9020370 Clint 2.29 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020370 Fup 0.939 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020370 Vd NA 0.6961 L/kg 1compartment NA NA Human Human DTXSID9020370 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9020370 TK.Half.Life NA 0.9799 hours 1compartment NA NA Human Human -DTXSID9020370 Css NA 0.1173 mg/L 3compartmentss NA 50% Human Human -DTXSID9020370 Css NA 0.5163 mg/L 3compartmentss NA 95% Human Human -DTXSID9020370 Css NA 0.09576 mg/L PBTK NA 50% Human Human -DTXSID9020370 Css NA 0.3984 mg/L PBTK NA 95% Human Human +DTXSID9020370 Css NA 0.09568 mg/L 3compartmentss NA 50% Human Human +DTXSID9020370 Css NA 0.4525 mg/L 3compartmentss NA 95% Human Human +DTXSID9020370 Css NA 0.07836 mg/L PBTK NA 50% Human Human +DTXSID9020370 Css NA 0.3441 mg/L PBTK NA 95% Human Human DTXSID9020370 Clint 2.29 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020370 Fup 0.939 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020370 Vd NA 0.7391 L/kg 1compartment NA NA Rat Human DTXSID9020370 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9020370 TK.Half.Life NA 0.5454 hours 1compartment NA NA Rat Human -DTXSID9020370 Css NA 0.05436 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020370 Css NA 0.1718 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020370 Css NA 0.04435 mg/L PBTK NA 50% Rat Human -DTXSID9020370 Css NA 0.1285 mg/L PBTK NA 95% Rat Human -DTXSID9020372 Clint NA 15.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020372 Fup NA 0.0179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020372 Vd NA 10.73 L/kg 1compartment NA NA Human Human -DTXSID9020372 Days.Css NA 96 Days PBTK NA NA Human Human -DTXSID9020372 TK.Half.Life NA 433.2 hours 1compartment NA NA Human Human -DTXSID9020372 Css NA 2.622 mg/L 3compartmentss NA 50% Human Human -DTXSID9020372 Css NA 15.73 mg/L 3compartmentss NA 95% Human Human -DTXSID9020372 Css NA 3.31 mg/L PBTK NA 50% Human Human -DTXSID9020372 Css NA 19.15 mg/L PBTK NA 95% Human Human -DTXSID9020372 Clint NA 15.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020372 Fup NA 0.0179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020372 Vd NA 8.476 L/kg 1compartment NA NA Rat Human -DTXSID9020372 Days.Css NA 57 Days PBTK NA NA Rat Human -DTXSID9020372 TK.Half.Life NA 59.6 hours 1compartment NA NA Rat Human -DTXSID9020372 Css NA 1.414 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020372 Css NA 6.214 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020372 Css NA 1.778 mg/L PBTK NA 50% Rat Human -DTXSID9020372 Css NA 7.578 mg/L PBTK NA 95% Rat Human -DTXSID9020378 Clint NA 27.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020378 Fup NA 0.15 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020378 Vd NA 1.852 L/kg 1compartment NA NA Human Human -DTXSID9020378 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020378 TK.Half.Life NA 2.802 hours 1compartment NA NA Human Human -DTXSID9020378 Css NA 0.1088 mg/L 3compartmentss NA 50% Human Human -DTXSID9020378 Css NA 0.9626 mg/L 3compartmentss NA 95% Human Human -DTXSID9020378 Css NA 0.08656 mg/L PBTK NA 50% Human Human -DTXSID9020378 Css NA 0.6626 mg/L PBTK NA 95% Human Human -DTXSID9020378 Clint NA 27.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020378 Fup NA 0.15 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020378 Vd NA 1.83 L/kg 1compartment NA NA Rat Human -DTXSID9020378 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020378 TK.Half.Life NA 1.564 hours 1compartment NA NA Rat Human -DTXSID9020378 Css NA 0.0597 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020378 Css NA 0.4205 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020378 Css NA 0.0457 mg/L PBTK NA 50% Rat Human -DTXSID9020378 Css NA 0.2777 mg/L PBTK NA 95% Rat Human -DTXSID9020401 Clint NA 39.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020401 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020401 Vd NA 1.142 L/kg 1compartment NA NA Human Human +DTXSID9020370 Css NA 0.002816 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020370 Css NA 0.01731 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020370 Css NA 0.00228 mg/L PBTK NA 50% Rat Human +DTXSID9020370 Css NA 0.01343 mg/L PBTK NA 95% Rat Human +DTXSID9020372 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020372 Fup 0.0103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020372 Vd NA 3.158 L/kg 1compartment NA NA Human Human +DTXSID9020372 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID9020372 TK.Half.Life NA 95.84 hours 1compartment NA NA Human Human +DTXSID9020372 Css NA 3.386 mg/L 3compartmentss NA 50% Human Human +DTXSID9020372 Css NA 19.85 mg/L 3compartmentss NA 95% Human Human +DTXSID9020372 Css NA 2.37 mg/L PBTK NA 50% Human Human +DTXSID9020372 Css NA 13.72 mg/L PBTK NA 95% Human Human +DTXSID9020372 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020372 Fup 0.0103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020372 Vd NA 2.367 L/kg 1compartment NA NA Rat Human +DTXSID9020372 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID9020372 TK.Half.Life NA 13.02 hours 1compartment NA NA Rat Human +DTXSID9020372 Css NA 0.4516 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020372 Css NA 2.203 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020372 Css NA 0.3121 mg/L PBTK NA 50% Rat Human +DTXSID9020372 Css NA 1.523 mg/L PBTK NA 95% Rat Human +DTXSID90203740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90203740 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90203740 Vd NA 0.9721 L/kg 1compartment NA NA Human Human +DTXSID90203740 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID90203740 TK.Half.Life NA 45.27 hours 1compartment NA NA Human Human +DTXSID90203740 Css NA 8.221 mg/L 3compartmentss NA 50% Human Human +DTXSID90203740 Css NA 76.77 mg/L 3compartmentss NA 95% Human Human +DTXSID90203740 Css NA 4.93 mg/L PBTK NA 50% Human Human +DTXSID90203740 Css NA 45.31 mg/L PBTK NA 95% Human Human +DTXSID90203740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90203740 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90203740 Vd NA 0.7102 L/kg 1compartment NA NA Rat Human +DTXSID90203740 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID90203740 TK.Half.Life NA 20.16 hours 1compartment NA NA Rat Human +DTXSID90203740 Css NA 1.102 mg/L 3compartmentss NA 50% Rat Human +DTXSID90203740 Css NA 8.749 mg/L 3compartmentss NA 95% Rat Human +DTXSID90203740 Css NA 0.6373 mg/L PBTK NA 50% Rat Human +DTXSID90203740 Css NA 4.94 mg/L PBTK NA 95% Rat Human +DTXSID9020376 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9020376 Fup NA 0.0163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9020376 Vd NA 4.75 L/kg 1compartment NA NA Human Human +DTXSID9020376 Days.Css NA 8526 Days PBTK NA NA Human Human +DTXSID9020376 TK.Half.Life NA 226300 hours 1compartment NA NA Human Human +DTXSID9020376 Css NA 3917 mg/L 3compartmentss NA 50% Human Human +DTXSID9020376 Css NA 9276 mg/L 3compartmentss NA 95% Human Human +DTXSID9020376 Css NA 3139 mg/L PBTK NA 50% Human Human +DTXSID9020376 Css NA 6991 mg/L PBTK NA 95% Human Human +DTXSID9020376 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9020376 Fup NA 0.0163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9020376 Vd NA 3.619 L/kg 1compartment NA NA Rat Human +DTXSID9020376 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID9020376 TK.Half.Life NA 14370 hours 1compartment NA NA Rat Human +DTXSID9020376 Css NA 64.66 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020376 Css NA 296.9 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020376 Css NA 50.55 mg/L PBTK NA 50% Rat Human +DTXSID9020376 Css NA 226.7 mg/L PBTK NA 95% Rat Human +DTXSID9020378 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020378 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020378 Vd NA 3.377 L/kg 1compartment NA NA Human Human +DTXSID9020378 Days.Css NA 17 Days PBTK NA NA Human Human +DTXSID9020378 TK.Half.Life NA 97.74 hours 1compartment NA NA Human Human +DTXSID9020378 Css NA 2.122 mg/L 3compartmentss NA 50% Human Human +DTXSID9020378 Css NA 9.435 mg/L 3compartmentss NA 95% Human Human +DTXSID9020378 Css NA 2.3 mg/L PBTK NA 50% Human Human +DTXSID9020378 Css NA 7.536 mg/L PBTK NA 95% Human Human +DTXSID9020378 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020378 Fup 0.262 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020378 Vd NA 3.311 L/kg 1compartment NA NA Rat Human +DTXSID9020378 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID9020378 TK.Half.Life NA 29 hours 1compartment NA NA Rat Human +DTXSID9020378 Css NA 0.1309 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020378 Css NA 0.5037 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020378 Css NA 0.1451 mg/L PBTK NA 50% Rat Human +DTXSID9020378 Css NA 0.386 mg/L PBTK NA 95% Rat Human +DTXSID9020401 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020401 Fup 0.658 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020401 Vd NA 0.9457 L/kg 1compartment NA NA Human Human DTXSID9020401 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020401 TK.Half.Life NA 0.6843 hours 1compartment NA NA Human Human -DTXSID9020401 Css NA 0.01254 mg/L 3compartmentss NA 50% Human Human -DTXSID9020401 Css NA 0.1755 mg/L 3compartmentss NA 95% Human Human -DTXSID9020401 Css NA 0.01125 mg/L PBTK NA 50% Human Human -DTXSID9020401 Css NA 0.1363 mg/L PBTK NA 95% Human Human -DTXSID9020401 Clint NA 39.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020401 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020401 Vd NA 1.131 L/kg 1compartment NA NA Rat Human +DTXSID9020401 TK.Half.Life NA 9.476 hours 1compartment NA NA Human Human +DTXSID9020401 Css NA 1.07 mg/L 3compartmentss NA 50% Human Human +DTXSID9020401 Css NA 6.898 mg/L 3compartmentss NA 95% Human Human +DTXSID9020401 Css NA 0.902 mg/L PBTK NA 50% Human Human +DTXSID9020401 Css NA 4.479 mg/L PBTK NA 95% Human Human +DTXSID9020401 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020401 Fup 0.658 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020401 Vd NA 0.9222 L/kg 1compartment NA NA Rat Human DTXSID9020401 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020401 TK.Half.Life NA 0.3118 hours 1compartment NA NA Rat Human -DTXSID9020401 Css NA 0.006291 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020401 Css NA 0.07002 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020401 Css NA 0.005602 mg/L PBTK NA 50% Rat Human -DTXSID9020401 Css NA 0.05274 mg/L PBTK NA 95% Rat Human +DTXSID9020401 TK.Half.Life NA 3.104 hours 1compartment NA NA Rat Human +DTXSID9020401 Css NA 0.06409 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020401 Css NA 0.4225 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020401 Css NA 0.05428 mg/L PBTK NA 50% Rat Human +DTXSID9020401 Css NA 0.2607 mg/L PBTK NA 95% Rat Human DTXSID9020407 Clint 30.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020407 Fup 0.0388 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020407 Vd NA 2.392 L/kg 1compartment NA NA Human Human DTXSID9020407 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID9020407 TK.Half.Life NA 13.92 hours 1compartment NA NA Human Human -DTXSID9020407 Css NA 0.6673 mg/L 3compartmentss NA 50% Human Human -DTXSID9020407 Css NA 4.2 mg/L 3compartmentss NA 95% Human Human -DTXSID9020407 Css NA 0.4502 mg/L PBTK NA 50% Human Human -DTXSID9020407 Css NA 2.697 mg/L PBTK NA 95% Human Human +DTXSID9020407 Css NA 0.6483 mg/L 3compartmentss NA 50% Human Human +DTXSID9020407 Css NA 4.179 mg/L 3compartmentss NA 95% Human Human +DTXSID9020407 Css NA 0.4361 mg/L PBTK NA 50% Human Human +DTXSID9020407 Css NA 2.689 mg/L PBTK NA 95% Human Human DTXSID9020407 Clint 30.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020407 Fup 0.0388 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020407 Vd NA 1.79 L/kg 1compartment NA NA Rat Human DTXSID9020407 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9020407 TK.Half.Life NA 3.786 hours 1compartment NA NA Rat Human -DTXSID9020407 Css NA 0.3706 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020407 Css NA 1.96 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020407 Css NA 0.237 mg/L PBTK NA 50% Rat Human -DTXSID9020407 Css NA 1.198 mg/L PBTK NA 95% Rat Human +DTXSID9020407 Css NA 0.08328 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020407 Css NA 0.4802 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020407 Css NA 0.05506 mg/L PBTK NA 50% Rat Human +DTXSID9020407 Css NA 0.3124 mg/L PBTK NA 95% Rat Human DTXSID9020409 Clint NA 171.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020409 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020409 Vd NA 9.878 L/kg 1compartment NA NA Human Human DTXSID9020409 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID9020409 TK.Half.Life NA 41.38 hours 1compartment NA NA Human Human -DTXSID9020409 Css NA 0.259 mg/L 3compartmentss NA 50% Human Human -DTXSID9020409 Css NA 1.562 mg/L 3compartmentss NA 95% Human Human -DTXSID9020409 Css NA 0.3082 mg/L PBTK NA 50% Human Human -DTXSID9020409 Css NA 1.797 mg/L PBTK NA 95% Human Human +DTXSID9020409 Css NA 0.2538 mg/L 3compartmentss NA 50% Human Human +DTXSID9020409 Css NA 1.517 mg/L 3compartmentss NA 95% Human Human +DTXSID9020409 Css NA 0.3001 mg/L PBTK NA 50% Human Human +DTXSID9020409 Css NA 1.73 mg/L PBTK NA 95% Human Human DTXSID9020409 Clint NA 171.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020409 Fup NA 0.0206 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020409 Vd NA 7.772 L/kg 1compartment NA NA Rat Human DTXSID9020409 Days.Css NA 3 Days PBTK NA NA Rat Human DTXSID9020409 TK.Half.Life NA 6.539 hours 1compartment NA NA Rat Human -DTXSID9020409 Css NA 0.142 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020409 Css NA 0.6177 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020409 Css NA 0.1666 mg/L PBTK NA 50% Rat Human -DTXSID9020409 Css NA 0.7106 mg/L PBTK NA 95% Rat Human -DTXSID9020451 Clint NA 1.455 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020451 Fup NA 0.1585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020451 Vd NA 2.832 L/kg 1compartment NA NA Human Human -DTXSID9020451 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID9020451 TK.Half.Life NA 138.4 hours 1compartment NA NA Human Human -DTXSID9020451 Css NA 5.994 mg/L 3compartmentss NA 50% Human Human -DTXSID9020451 Css NA 23.55 mg/L 3compartmentss NA 95% Human Human -DTXSID9020451 Css NA 4.238 mg/L PBTK NA 50% Human Human -DTXSID9020451 Css NA 15.89 mg/L PBTK NA 95% Human Human -DTXSID9020451 Clint NA 1.455 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020451 Fup NA 0.1585 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020451 Vd NA 2.136 L/kg 1compartment NA NA Rat Human -DTXSID9020451 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID9020451 TK.Half.Life NA 22.3 hours 1compartment NA NA Rat Human -DTXSID9020451 Css NA 2.75 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020451 Css NA 7.524 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020451 Css NA 1.861 mg/L PBTK NA 50% Rat Human -DTXSID9020451 Css NA 4.739 mg/L PBTK NA 95% Rat Human +DTXSID9020409 Css NA 0.03196 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020409 Css NA 0.1522 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020409 Css NA 0.0391 mg/L PBTK NA 50% Rat Human +DTXSID9020409 Css NA 0.1973 mg/L PBTK NA 95% Rat Human +DTXSID9020451 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020451 Fup 0.0609 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020451 Vd NA 2.419 L/kg 1compartment NA NA Human Human +DTXSID9020451 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9020451 TK.Half.Life NA 14.23 hours 1compartment NA NA Human Human +DTXSID9020451 Css NA 0.7352 mg/L 3compartmentss NA 50% Human Human +DTXSID9020451 Css NA 4.915 mg/L 3compartmentss NA 95% Human Human +DTXSID9020451 Css NA 0.4944 mg/L PBTK NA 50% Human Human +DTXSID9020451 Css NA 3.227 mg/L PBTK NA 95% Human Human +DTXSID9020451 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020451 Fup 0.0609 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020451 Vd NA 1.814 L/kg 1compartment NA NA Rat Human +DTXSID9020451 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9020451 TK.Half.Life NA 3.813 hours 1compartment NA NA Rat Human +DTXSID9020451 Css NA 0.09514 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020451 Css NA 0.5286 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020451 Css NA 0.06262 mg/L PBTK NA 50% Rat Human +DTXSID9020451 Css NA 0.3382 mg/L PBTK NA 95% Rat Human DTXSID9020453 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9020453 Fup 0.009376 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9020453 Vd NA 2.931 L/kg 1compartment NA NA Human Human DTXSID9020453 Days.Css NA 3276 Days PBTK NA NA Human Human DTXSID9020453 TK.Half.Life NA 20270 hours 1compartment NA NA Human Human -DTXSID9020453 Css NA 855.3 mg/L 3compartmentss NA 50% Human Human -DTXSID9020453 Css NA 2568 mg/L 3compartmentss NA 95% Human Human -DTXSID9020453 Css NA 584 mg/L PBTK NA 50% Human Human -DTXSID9020453 Css NA 1616 mg/L PBTK NA 95% Human Human +DTXSID9020453 Css NA 830.4 mg/L 3compartmentss NA 50% Human Human +DTXSID9020453 Css NA 2504 mg/L 3compartmentss NA 95% Human Human +DTXSID9020453 Css NA 564.8 mg/L PBTK NA 50% Human Human +DTXSID9020453 Css NA 1603 mg/L PBTK NA 95% Human Human DTXSID9020453 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9020453 Fup 0.009376 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9020453 Vd NA 2.192 L/kg 1compartment NA NA Rat Human -DTXSID9020453 Days.Css NA 1421 Days PBTK NA NA Rat Human +DTXSID9020453 Days.Css NA 1420 Days PBTK NA NA Rat Human DTXSID9020453 TK.Half.Life NA 1624 hours 1compartment NA NA Rat Human -DTXSID9020453 Css NA 233.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020453 Css NA 574.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020453 Css NA 151.5 mg/L PBTK NA 50% Rat Human -DTXSID9020453 Css NA 338.4 mg/L PBTK NA 95% Rat Human -DTXSID9020459 Clint NA 0.08824 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020459 Fup NA 0.9687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020459 Vd NA 1.27 L/kg 1compartment NA NA Human Human +DTXSID9020453 Css NA 52.54 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020453 Css NA 125.9 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020453 Css NA 35.34 mg/L PBTK NA 50% Rat Human +DTXSID9020453 Css NA 77.01 mg/L PBTK NA 95% Rat Human +DTXSID9020459 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020459 Fup 0.824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020459 Vd NA 1.144 L/kg 1compartment NA NA Human Human DTXSID9020459 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020459 TK.Half.Life NA 7.511 hours 1compartment NA NA Human Human -DTXSID9020459 Css NA 0.6616 mg/L 3compartmentss NA 50% Human Human -DTXSID9020459 Css NA 2.322 mg/L 3compartmentss NA 95% Human Human -DTXSID9020459 Css NA 0.6065 mg/L PBTK NA 50% Human Human -DTXSID9020459 Css NA 1.768 mg/L PBTK NA 95% Human Human -DTXSID9020459 Clint NA 0.08824 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020459 Fup NA 0.9687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020459 Vd NA 1.269 L/kg 1compartment NA NA Rat Human +DTXSID9020459 TK.Half.Life NA 9.089 hours 1compartment NA NA Human Human +DTXSID9020459 Css NA 0.7695 mg/L 3compartmentss NA 50% Human Human +DTXSID9020459 Css NA 5.065 mg/L 3compartmentss NA 95% Human Human +DTXSID9020459 Css NA 0.6891 mg/L PBTK NA 50% Human Human +DTXSID9020459 Css NA 3.322 mg/L PBTK NA 95% Human Human +DTXSID9020459 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020459 Fup 0.824 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020459 Vd NA 1.143 L/kg 1compartment NA NA Rat Human DTXSID9020459 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020459 TK.Half.Life NA 2.707 hours 1compartment NA NA Rat Human -DTXSID9020459 Css NA 0.1812 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020459 Css NA 0.5823 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020459 Css NA 0.1644 mg/L PBTK NA 50% Rat Human -DTXSID9020459 Css NA 0.4026 mg/L PBTK NA 95% Rat Human -DTXSID9020538 Clint NA 65.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020538 Fup NA 0.0232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020538 Vd NA 0.9444 L/kg 1compartment NA NA Human Human -DTXSID9020538 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020538 TK.Half.Life NA 3.074 hours 1compartment NA NA Human Human -DTXSID9020538 Css NA 0.4316 mg/L 3compartmentss NA 50% Human Human -DTXSID9020538 Css NA 4.215 mg/L 3compartmentss NA 95% Human Human -DTXSID9020538 Css NA 0.2642 mg/L PBTK NA 50% Human Human -DTXSID9020538 Css NA 2.489 mg/L PBTK NA 95% Human Human -DTXSID9020538 Clint NA 65.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020538 Fup NA 0.0232 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020538 Vd NA 0.7077 L/kg 1compartment NA NA Rat Human +DTXSID9020459 TK.Half.Life NA 3.067 hours 1compartment NA NA Rat Human +DTXSID9020459 Css NA 0.01451 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020459 Css NA 0.1136 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020459 Css NA 0.01257 mg/L PBTK NA 50% Rat Human +DTXSID9020459 Css NA 0.07672 mg/L PBTK NA 95% Rat Human +DTXSID9020538 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020538 Fup 0.0618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020538 Vd NA 1.106 L/kg 1compartment NA NA Human Human +DTXSID9020538 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9020538 TK.Half.Life NA 11.41 hours 1compartment NA NA Human Human +DTXSID9020538 Css NA 1.628 mg/L 3compartmentss NA 50% Human Human +DTXSID9020538 Css NA 10.78 mg/L 3compartmentss NA 95% Human Human +DTXSID9020538 Css NA 1.022 mg/L PBTK NA 50% Human Human +DTXSID9020538 Css NA 6.509 mg/L PBTK NA 95% Human Human +DTXSID9020538 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020538 Fup 0.0618 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020538 Vd NA 0.846 L/kg 1compartment NA NA Rat Human DTXSID9020538 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020538 TK.Half.Life NA 1.315 hours 1compartment NA NA Rat Human -DTXSID9020538 Css NA 0.2454 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020538 Css NA 1.961 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020538 Css NA 0.1401 mg/L PBTK NA 50% Rat Human -DTXSID9020538 Css NA 1.089 mg/L PBTK NA 95% Rat Human -DTXSID9020580 Clint NA 2.286 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020580 Fup NA 0.4091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020580 Vd NA 0.7282 L/kg 1compartment NA NA Human Human +DTXSID9020538 TK.Half.Life NA 4.834 hours 1compartment NA NA Rat Human +DTXSID9020538 Css NA 0.1998 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020538 Css NA 1.039 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020538 Css NA 0.1224 mg/L PBTK NA 50% Rat Human +DTXSID9020538 Css NA 0.6022 mg/L PBTK NA 95% Rat Human +DTXSID9020580 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020580 Fup 0.578 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020580 Vd NA 0.788 L/kg 1compartment NA NA Human Human DTXSID9020580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020580 TK.Half.Life NA 2.755 hours 1compartment NA NA Human Human -DTXSID9020580 Css NA 0.378 mg/L 3compartmentss NA 50% Human Human -DTXSID9020580 Css NA 2.067 mg/L 3compartmentss NA 95% Human Human -DTXSID9020580 Css NA 0.2864 mg/L PBTK NA 50% Human Human -DTXSID9020580 Css NA 1.372 mg/L PBTK NA 95% Human Human -DTXSID9020580 Clint NA 2.286 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020580 Fup NA 0.4091 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020580 Vd NA 0.6929 L/kg 1compartment NA NA Rat Human +DTXSID9020580 TK.Half.Life NA 1.209 hours 1compartment NA NA Human Human +DTXSID9020580 Css NA 0.1136 mg/L 3compartmentss NA 50% Human Human +DTXSID9020580 Css NA 1.046 mg/L 3compartmentss NA 95% Human Human +DTXSID9020580 Css NA 0.09145 mg/L PBTK NA 50% Human Human +DTXSID9020580 Css NA 0.6854 mg/L PBTK NA 95% Human Human +DTXSID9020580 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020580 Fup 0.578 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020580 Vd NA 0.7722 L/kg 1compartment NA NA Rat Human DTXSID9020580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020580 TK.Half.Life NA 1.403 hours 1compartment NA NA Rat Human -DTXSID9020580 Css NA 0.1724 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020580 Css NA 0.7567 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020580 Css NA 0.1255 mg/L PBTK NA 50% Rat Human -DTXSID9020580 Css NA 0.4592 mg/L PBTK NA 95% Rat Human +DTXSID9020580 TK.Half.Life NA 0.64 hours 1compartment NA NA Rat Human +DTXSID9020580 Css NA 0.01296 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020580 Css NA 0.1009 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020580 Css NA 0.01046 mg/L PBTK NA 50% Rat Human +DTXSID9020580 Css NA 0.06165 mg/L PBTK NA 95% Rat Human DTXSID9020582 Clint 15.16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9020582 Fup 0.01069 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9020582 Vd NA 0.7523 L/kg 1compartment NA NA Human Human -DTXSID9020582 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9020582 TK.Half.Life NA 15.41 hours 1compartment NA NA Human Human -DTXSID9020582 Css NA 3.649 mg/L 3compartmentss NA 50% Human Human -DTXSID9020582 Css NA 34.03 mg/L 3compartmentss NA 95% Human Human -DTXSID9020582 Css NA 2.178 mg/L PBTK NA 50% Human Human -DTXSID9020582 Css NA 19.92 mg/L PBTK NA 95% Human Human +DTXSID9020582 Vd NA 1.449 L/kg 1compartment NA NA Human Human +DTXSID9020582 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9020582 TK.Half.Life NA 28.8 hours 1compartment NA NA Human Human +DTXSID9020582 Css NA 3.282 mg/L 3compartmentss NA 50% Human Human +DTXSID9020582 Css NA 28.86 mg/L 3compartmentss NA 95% Human Human +DTXSID9020582 Css NA 2.037 mg/L PBTK NA 50% Human Human +DTXSID9020582 Css NA 17.41 mg/L PBTK NA 95% Human Human DTXSID9020582 Clint 15.16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9020582 Fup 0.01069 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID9020582 Vd NA 0.5607 L/kg 1compartment NA NA Rat Human -DTXSID9020582 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020582 TK.Half.Life NA 7.165 hours 1compartment NA NA Rat Human -DTXSID9020582 Css NA 2.064 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020582 Css NA 15.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020582 Css NA 1.155 mg/L PBTK NA 50% Rat Human -DTXSID9020582 Css NA 8.704 mg/L PBTK NA 95% Rat Human +DTXSID9020582 Vd NA 1.103 L/kg 1compartment NA NA Rat Human +DTXSID9020582 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9020582 TK.Half.Life NA 11.93 hours 1compartment NA NA Rat Human +DTXSID9020582 Css NA 0.4287 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020582 Css NA 3.153 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020582 Css NA 0.2603 mg/L PBTK NA 50% Rat Human +DTXSID9020582 Css NA 1.805 mg/L PBTK NA 95% Rat Human DTXSID9020584 Clint 19.98 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID9020584 Fup 0.9338 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Human Human DTXSID9020584 Vd NA 0.8452 L/kg 1compartment NA NA Human Human DTXSID9020584 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9020584 TK.Half.Life NA 0.6167 hours 1compartment NA NA Human Human -DTXSID9020584 Css NA 0.02837 mg/L 3compartmentss NA 50% Human Human -DTXSID9020584 Css NA 0.2701 mg/L 3compartmentss NA 95% Human Human -DTXSID9020584 Css NA 0.0234 mg/L PBTK NA 50% Human Human -DTXSID9020584 Css NA 0.1975 mg/L PBTK NA 95% Human Human +DTXSID9020584 Css NA 0.02063 mg/L 3compartmentss NA 50% Human Human +DTXSID9020584 Css NA 0.2291 mg/L 3compartmentss NA 95% Human Human +DTXSID9020584 Css NA 0.017 mg/L PBTK NA 50% Human Human +DTXSID9020584 Css NA 0.1656 mg/L PBTK NA 95% Human Human DTXSID9020584 Clint 31.1 NA uL/min/million hepatocytes NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID9020584 Fup 0.842 NA NA https://doi.org/10.1038/s41370-020-0238-y NA Rat Rat DTXSID9020584 Vd NA 0.8136 L/kg 1compartment NA NA Rat Rat DTXSID9020584 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9020584 TK.Half.Life NA 0.2707 hours 1compartment NA NA Rat Rat -DTXSID9020584 Css NA 0.009901 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9020584 Css NA 0.08739 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9020584 Css NA 0.008111 mg/L PBTK NA 50% Rat Rat -DTXSID9020584 Css NA 0.05855 mg/L PBTK NA 95% Rat Rat +DTXSID9020584 Css NA 0.000462 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9020584 Css NA 0.00669 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9020584 Css NA 0.0003756 mg/L PBTK NA 50% Rat Rat +DTXSID9020584 Css NA 0.004661 mg/L PBTK NA 95% Rat Rat +DTXSID90205860 Clint 150 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90205860 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90205860 Vd NA 1 L/kg 1compartment NA NA Human Human +DTXSID90205860 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90205860 TK.Half.Life NA 0.9455 hours 1compartment NA NA Human Human +DTXSID90205860 Css NA 0.01572 mg/L 3compartmentss NA 50% Human Human +DTXSID90205860 Css NA 0.1311 mg/L 3compartmentss NA 95% Human Human +DTXSID90205860 Css NA 0.01082 mg/L PBTK NA 50% Human Human +DTXSID90205860 Css NA 0.08546 mg/L PBTK NA 95% Human Human +DTXSID90205860 Clint 150 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90205860 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90205860 Vd NA 0.8117 L/kg 1compartment NA NA Rat Human +DTXSID90205860 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90205860 TK.Half.Life NA 0.356 hours 1compartment NA NA Rat Human +DTXSID90205860 Css NA 0.002126 mg/L 3compartmentss NA 50% Rat Human +DTXSID90205860 Css NA 0.0137 mg/L 3compartmentss NA 95% Rat Human +DTXSID90205860 Css NA 0.001455 mg/L PBTK NA 50% Rat Human +DTXSID90205860 Css NA 0.008886 mg/L PBTK NA 95% Rat Human DTXSID9020615 Clint 7.9 NA uL/min/million hepatocytes NA https://doi.org/10.3109/00498254.2012.669080 NA Human Human DTXSID9020615 Fup 0.008 NA NA https://doi.org/10.3109/00498254.2012.669080 NA Human Human -DTXSID9020615 Vd NA 0.372 L/kg 1compartment NA NA Human Human -DTXSID9020615 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9020615 TK.Half.Life NA 19.58 hours 1compartment NA NA Human Human -DTXSID9020615 Css NA 9.304 mg/L 3compartmentss NA 50% Human Human -DTXSID9020615 Css NA 84.64 mg/L 3compartmentss NA 95% Human Human -DTXSID9020615 Css NA 5.722 mg/L PBTK NA 50% Human Human -DTXSID9020615 Css NA 49.38 mg/L PBTK NA 95% Human Human +DTXSID9020615 Vd NA 0.8939 L/kg 1compartment NA NA Human Human +DTXSID9020615 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID9020615 TK.Half.Life NA 41.76 hours 1compartment NA NA Human Human +DTXSID9020615 Css NA 8.272 mg/L 3compartmentss NA 50% Human Human +DTXSID9020615 Css NA 71.87 mg/L 3compartmentss NA 95% Human Human +DTXSID9020615 Css NA 4.962 mg/L PBTK NA 50% Human Human +DTXSID9020615 Css NA 43.12 mg/L PBTK NA 95% Human Human DTXSID9020615 Clint 7.9 NA uL/min/million hepatocytes NA https://doi.org/10.3109/00498254.2012.669080 NA Rat Human DTXSID9020615 Fup 0.008 NA NA https://doi.org/10.3109/00498254.2012.669080 NA Rat Human -DTXSID9020615 Vd NA 0.3049 L/kg 1compartment NA NA Rat Human -DTXSID9020615 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9020615 TK.Half.Life NA 10.35 hours 1compartment NA NA Rat Human -DTXSID9020615 Css NA 5.13 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020615 Css NA 37.58 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020615 Css NA 2.926 mg/L PBTK NA 50% Rat Human -DTXSID9020615 Css NA 20.51 mg/L PBTK NA 95% Rat Human +DTXSID9020615 Vd NA 0.6595 L/kg 1compartment NA NA Rat Human +DTXSID9020615 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9020615 TK.Half.Life NA 18.45 hours 1compartment NA NA Rat Human +DTXSID9020615 Css NA 0.9819 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020615 Css NA 6.686 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020615 Css NA 0.61 mg/L PBTK NA 50% Rat Human +DTXSID9020615 Css NA 4.154 mg/L PBTK NA 95% Rat Human DTXSID9020617 Clint 103.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9020617 Fup 0.1922 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9020617 Vd NA 1.368 L/kg 1compartment NA NA Human Human DTXSID9020617 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9020617 TK.Half.Life NA 1.364 hours 1compartment NA NA Human Human -DTXSID9020617 Css NA 0.02778 mg/L 3compartmentss NA 50% Human Human -DTXSID9020617 Css NA 0.203 mg/L 3compartmentss NA 95% Human Human -DTXSID9020617 Css NA 0.01981 mg/L PBTK NA 50% Human Human -DTXSID9020617 Css NA 0.1361 mg/L PBTK NA 95% Human Human +DTXSID9020617 Css NA 0.0245 mg/L 3compartmentss NA 50% Human Human +DTXSID9020617 Css NA 0.2028 mg/L 3compartmentss NA 95% Human Human +DTXSID9020617 Css NA 0.01742 mg/L PBTK NA 50% Human Human +DTXSID9020617 Css NA 0.1347 mg/L PBTK NA 95% Human Human DTXSID9020617 Clint 103.6 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9020617 Fup 0.1922 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9020617 Vd NA 1.086 L/kg 1compartment NA NA Rat Human DTXSID9020617 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9020617 TK.Half.Life NA 0.5034 hours 1compartment NA NA Rat Human -DTXSID9020617 Css NA 0.01538 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020617 Css NA 0.09048 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020617 Css NA 0.01046 mg/L PBTK NA 50% Rat Human -DTXSID9020617 Css NA 0.05886 mg/L PBTK NA 95% Rat Human +DTXSID9020617 Css NA 0.003274 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020617 Css NA 0.01967 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020617 Css NA 0.002301 mg/L PBTK NA 50% Rat Human +DTXSID9020617 Css NA 0.01342 mg/L PBTK NA 95% Rat Human +DTXSID90206493 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90206493 Fup 0.043 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90206493 Vd NA 1.204 L/kg 1compartment NA NA Human Human +DTXSID90206493 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID90206493 TK.Half.Life NA 17.33 hours 1compartment NA NA Human Human +DTXSID90206493 Css NA 2.285 mg/L 3compartmentss NA 50% Human Human +DTXSID90206493 Css NA 14.13 mg/L 3compartmentss NA 95% Human Human +DTXSID90206493 Css NA 1.429 mg/L PBTK NA 50% Human Human +DTXSID90206493 Css NA 8.64 mg/L PBTK NA 95% Human Human +DTXSID90206493 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90206493 Fup 0.043 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90206493 Vd NA 0.9055 L/kg 1compartment NA NA Rat Human +DTXSID90206493 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90206493 TK.Half.Life NA 7.076 hours 1compartment NA NA Rat Human +DTXSID90206493 Css NA 0.2818 mg/L 3compartmentss NA 50% Rat Human +DTXSID90206493 Css NA 1.387 mg/L 3compartmentss NA 95% Rat Human +DTXSID90206493 Css NA 0.1717 mg/L PBTK NA 50% Rat Human +DTXSID90206493 Css NA 0.8097 mg/L PBTK NA 95% Rat Human DTXSID9020663 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020663 Fup NA 0.9513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020663 Vd NA 0.7318 L/kg 1compartment NA NA Human Human DTXSID9020663 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9020663 TK.Half.Life NA 4.98 hours 1compartment NA NA Human Human -DTXSID9020663 Css NA 0.9085 mg/L 3compartmentss NA 50% Human Human -DTXSID9020663 Css NA 4.979 mg/L 3compartmentss NA 95% Human Human -DTXSID9020663 Css NA 0.7483 mg/L PBTK NA 50% Human Human -DTXSID9020663 Css NA 3.228 mg/L PBTK NA 95% Human Human +DTXSID9020663 Css NA 0.7749 mg/L 3compartmentss NA 50% Human Human +DTXSID9020663 Css NA 4.35 mg/L 3compartmentss NA 95% Human Human +DTXSID9020663 Css NA 0.6395 mg/L PBTK NA 50% Human Human +DTXSID9020663 Css NA 2.805 mg/L PBTK NA 95% Human Human DTXSID9020663 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020663 Fup NA 0.9513 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020663 Vd NA 0.7755 L/kg 1compartment NA NA Rat Human DTXSID9020663 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9020663 TK.Half.Life NA 1.797 hours 1compartment NA NA Rat Human -DTXSID9020663 Css NA 0.2316 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020663 Css NA 1.243 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020663 Css NA 0.185 mg/L PBTK NA 50% Rat Human -DTXSID9020663 Css NA 0.7505 mg/L PBTK NA 95% Rat Human +DTXSID9020663 Css NA 0.01429 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020663 Css NA 0.1036 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020663 Css NA 0.01134 mg/L PBTK NA 50% Rat Human +DTXSID9020663 Css NA 0.0668 mg/L PBTK NA 95% Rat Human DTXSID9020667 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020667 Fup NA 0.8249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020667 Vd NA 0.6005 L/kg 1compartment NA NA Human Human DTXSID9020667 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9020667 TK.Half.Life NA 4.709 hours 1compartment NA NA Human Human -DTXSID9020667 Css NA 0.9719 mg/L 3compartmentss NA 50% Human Human -DTXSID9020667 Css NA 4.22 mg/L 3compartmentss NA 95% Human Human -DTXSID9020667 Css NA 0.7743 mg/L PBTK NA 50% Human Human -DTXSID9020667 Css NA 2.783 mg/L PBTK NA 95% Human Human +DTXSID9020667 Css NA 0.8364 mg/L 3compartmentss NA 50% Human Human +DTXSID9020667 Css NA 3.693 mg/L 3compartmentss NA 95% Human Human +DTXSID9020667 Css NA 0.6648 mg/L PBTK NA 50% Human Human +DTXSID9020667 Css NA 2.472 mg/L PBTK NA 95% Human Human DTXSID9020667 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020667 Fup NA 0.8249 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020667 Vd NA 0.648 L/kg 1compartment NA NA Rat Human DTXSID9020667 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9020667 TK.Half.Life NA 1.732 hours 1compartment NA NA Rat Human -DTXSID9020667 Css NA 0.2554 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020667 Css NA 1.018 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020667 Css NA 0.1961 mg/L PBTK NA 50% Rat Human -DTXSID9020667 Css NA 0.6228 mg/L PBTK NA 95% Rat Human -DTXSID9020669 Clint NA 14.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020669 Fup NA 0.0179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020669 Vd NA 0.3041 L/kg 1compartment NA NA Human Human +DTXSID9020667 Css NA 0.01494 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020667 Css NA 0.09154 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020667 Css NA 0.01138 mg/L PBTK NA 50% Rat Human +DTXSID9020667 Css NA 0.06172 mg/L PBTK NA 95% Rat Human +DTXSID9020669 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020669 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020669 Vd NA 0.3508 L/kg 1compartment NA NA Human Human DTXSID9020669 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020669 TK.Half.Life NA 4.412 hours 1compartment NA NA Human Human -DTXSID9020669 Css NA 2.609 mg/L 3compartmentss NA 50% Human Human -DTXSID9020669 Css NA 24.45 mg/L 3compartmentss NA 95% Human Human -DTXSID9020669 Css NA 1.545 mg/L PBTK NA 50% Human Human -DTXSID9020669 Css NA 14.43 mg/L PBTK NA 95% Human Human -DTXSID9020669 Clint NA 14.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020669 Fup NA 0.0179 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020669 Vd NA 0.3934 L/kg 1compartment NA NA Rat Human +DTXSID9020669 TK.Half.Life NA 2.207 hours 1compartment NA NA Human Human +DTXSID9020669 Css NA 0.8568 mg/L 3compartmentss NA 50% Human Human +DTXSID9020669 Css NA 8.623 mg/L 3compartmentss NA 95% Human Human +DTXSID9020669 Css NA 0.5174 mg/L PBTK NA 50% Human Human +DTXSID9020669 Css NA 5.069 mg/L PBTK NA 95% Human Human +DTXSID9020669 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020669 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020669 Vd NA 0.3669 L/kg 1compartment NA NA Rat Human DTXSID9020669 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020669 TK.Half.Life NA 1.431 hours 1compartment NA NA Rat Human -DTXSID9020669 Css NA 0.4934 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020669 Css NA 3.17 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020669 Css NA 0.2844 mg/L PBTK NA 50% Rat Human -DTXSID9020669 Css NA 1.768 mg/L PBTK NA 95% Rat Human +DTXSID9020669 TK.Half.Life NA 0.977 hours 1compartment NA NA Rat Human +DTXSID9020669 Css NA 0.02522 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020669 Css NA 0.2503 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020669 Css NA 0.01494 mg/L PBTK NA 50% Rat Human +DTXSID9020669 Css NA 0.1429 mg/L PBTK NA 95% Rat Human DTXSID9020740 Clint 9.35 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020740 Fup 0.0103 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020740 Vd NA 2.218 L/kg 1compartment NA NA Human Human DTXSID9020740 Days.Css NA 13 Days PBTK NA NA Human Human DTXSID9020740 TK.Half.Life NA 79.05 hours 1compartment NA NA Human Human -DTXSID9020740 Css NA 4.368 mg/L 3compartmentss NA 50% Human Human -DTXSID9020740 Css NA 26.26 mg/L 3compartmentss NA 95% Human Human -DTXSID9020740 Css NA 2.894 mg/L PBTK NA 50% Human Human -DTXSID9020740 Css NA 16.48 mg/L PBTK NA 95% Human Human +DTXSID9020740 Css NA 4.206 mg/L 3compartmentss NA 50% Human Human +DTXSID9020740 Css NA 25.64 mg/L 3compartmentss NA 95% Human Human +DTXSID9020740 Css NA 2.784 mg/L PBTK NA 50% Human Human +DTXSID9020740 Css NA 16.4 mg/L PBTK NA 95% Human Human DTXSID9020740 Clint 1.062 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID9020740 Fup 0.003 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID9020740 Vd NA 1.046 L/kg 1compartment NA NA Rat Rat -DTXSID9020740 Days.Css NA 81 Days PBTK NA NA Rat Rat +DTXSID9020740 Days.Css NA 80 Days PBTK NA NA Rat Rat DTXSID9020740 TK.Half.Life NA 253.6 hours 1compartment NA NA Rat Rat -DTXSID9020740 Css NA 44.16 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9020740 Css NA 175.8 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9020740 Css NA 25.29 mg/L PBTK NA 50% Rat Rat -DTXSID9020740 Css NA 97.31 mg/L PBTK NA 95% Rat Rat +DTXSID9020740 Css NA 9.932 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9020740 Css NA 40.74 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9020740 Css NA 5.898 mg/L PBTK NA 50% Rat Rat +DTXSID9020740 Css NA 23.27 mg/L PBTK NA 95% Rat Rat DTXSID9020742 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020742 Fup NA 0.8286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020742 Vd NA 0.7893 L/kg 1compartment NA NA Human Human DTXSID9020742 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9020742 TK.Half.Life NA 6.189 hours 1compartment NA NA Human Human -DTXSID9020742 Css NA 0.9632 mg/L 3compartmentss NA 50% Human Human -DTXSID9020742 Css NA 5.424 mg/L 3compartmentss NA 95% Human Human -DTXSID9020742 Css NA 0.8018 mg/L PBTK NA 50% Human Human -DTXSID9020742 Css NA 3.581 mg/L PBTK NA 95% Human Human +DTXSID9020742 Css NA 0.8199 mg/L 3compartmentss NA 50% Human Human +DTXSID9020742 Css NA 4.927 mg/L 3compartmentss NA 95% Human Human +DTXSID9020742 Css NA 0.682 mg/L PBTK NA 50% Human Human +DTXSID9020742 Css NA 3.227 mg/L PBTK NA 95% Human Human DTXSID9020742 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020742 Fup NA 0.8286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020742 Vd NA 0.8065 L/kg 1compartment NA NA Rat Human DTXSID9020742 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9020742 TK.Half.Life NA 2.147 hours 1compartment NA NA Rat Human -DTXSID9020742 Css NA 0.2476 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020742 Css NA 1.464 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020742 Css NA 0.2 mg/L PBTK NA 50% Rat Human -DTXSID9020742 Css NA 0.8796 mg/L PBTK NA 95% Rat Human +DTXSID9020742 Css NA 0.01532 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020742 Css NA 0.1144 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020742 Css NA 0.01226 mg/L PBTK NA 50% Rat Human +DTXSID9020742 Css NA 0.07461 mg/L PBTK NA 95% Rat Human DTXSID9020790 Clint 55.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020790 Fup 0.538 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9020790 Vd NA 1.496 L/kg 1compartment NA NA Human Human +DTXSID9020790 Vd NA 1.616 L/kg 1compartment NA NA Human Human DTXSID9020790 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020790 TK.Half.Life NA 1.136 hours 1compartment NA NA Human Human -DTXSID9020790 Css NA 0.01346 mg/L 3compartmentss NA 50% Human Human -DTXSID9020790 Css NA 0.08566 mg/L 3compartmentss NA 95% Human Human -DTXSID9020790 Css NA 0.01168 mg/L PBTK NA 50% Human Human -DTXSID9020790 Css NA 0.06843 mg/L PBTK NA 95% Human Human +DTXSID9020790 TK.Half.Life NA 1.238 hours 1compartment NA NA Human Human +DTXSID9020790 Css NA 0.0119 mg/L 3compartmentss NA 50% Human Human +DTXSID9020790 Css NA 0.08676 mg/L 3compartmentss NA 95% Human Human +DTXSID9020790 Css NA 0.0103 mg/L PBTK NA 50% Human Human +DTXSID9020790 Css NA 0.06964 mg/L PBTK NA 95% Human Human DTXSID9020790 Clint 55.9 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020790 Fup 0.538 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9020790 Vd NA 1.275 L/kg 1compartment NA NA Rat Human +DTXSID9020790 Vd NA 1.359 L/kg 1compartment NA NA Rat Human DTXSID9020790 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020790 TK.Half.Life NA 0.4423 hours 1compartment NA NA Rat Human -DTXSID9020790 Css NA 0.006985 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020790 Css NA 0.03723 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020790 Css NA 0.005974 mg/L PBTK NA 50% Rat Human -DTXSID9020790 Css NA 0.02977 mg/L PBTK NA 95% Rat Human +DTXSID9020790 TK.Half.Life NA 0.4718 hours 1compartment NA NA Rat Human +DTXSID9020790 Css NA 0.001494 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020790 Css NA 0.00919 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020790 Css NA 0.001338 mg/L PBTK NA 50% Rat Human +DTXSID9020790 Css NA 0.0078 mg/L PBTK NA 95% Rat Human DTXSID9020792 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020792 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020792 Vd NA 0.6917 L/kg 1compartment NA NA Human Human DTXSID9020792 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9020792 TK.Half.Life NA 4.478 hours 1compartment NA NA Human Human -DTXSID9020792 Css NA 0.5596 mg/L 3compartmentss NA 50% Human Human -DTXSID9020792 Css NA 3.085 mg/L 3compartmentss NA 95% Human Human -DTXSID9020792 Css NA 0.4657 mg/L PBTK NA 50% Human Human -DTXSID9020792 Css NA 2.12 mg/L PBTK NA 95% Human Human +DTXSID9020792 Css NA 0.4698 mg/L 3compartmentss NA 50% Human Human +DTXSID9020792 Css NA 2.64 mg/L 3compartmentss NA 95% Human Human +DTXSID9020792 Css NA 0.3897 mg/L PBTK NA 50% Human Human +DTXSID9020792 Css NA 1.839 mg/L PBTK NA 95% Human Human DTXSID9020792 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020792 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020792 Vd NA 0.722 L/kg 1compartment NA NA Rat Human DTXSID9020792 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9020792 TK.Half.Life NA 1.592 hours 1compartment NA NA Rat Human -DTXSID9020792 Css NA 0.1743 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020792 Css NA 0.6901 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020792 Css NA 0.1456 mg/L PBTK NA 50% Rat Human -DTXSID9020792 Css NA 0.438 mg/L PBTK NA 95% Rat Human -DTXSID9020794 Clint NA 2.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020794 Fup NA 0.6137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020794 Vd NA 1.674 L/kg 1compartment NA NA Human Human +DTXSID9020792 Css NA 0.005713 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020792 Css NA 0.06379 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020792 Css NA 0.004556 mg/L PBTK NA 50% Rat Human +DTXSID9020792 Css NA 0.04515 mg/L PBTK NA 95% Rat Human +DTXSID9020794 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020794 Fup 0.459 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020794 Vd NA 0.5966 L/kg 1compartment NA NA Human Human DTXSID9020794 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020794 TK.Half.Life NA 4.643 hours 1compartment NA NA Human Human -DTXSID9020794 Css NA 0.2492 mg/L 3compartmentss NA 50% Human Human -DTXSID9020794 Css NA 2.105 mg/L 3compartmentss NA 95% Human Human -DTXSID9020794 Css NA 0.2312 mg/L PBTK NA 50% Human Human -DTXSID9020794 Css NA 1.433 mg/L PBTK NA 95% Human Human -DTXSID9020794 Clint NA 2.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020794 Fup NA 0.6137 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020794 Vd NA 1.652 L/kg 1compartment NA NA Rat Human +DTXSID9020794 TK.Half.Life NA 8.409 hours 1compartment NA NA Human Human +DTXSID9020794 Css NA 1.488 mg/L 3compartmentss NA 50% Human Human +DTXSID9020794 Css NA 6.834 mg/L 3compartmentss NA 95% Human Human +DTXSID9020794 Css NA 1.15 mg/L PBTK NA 50% Human Human +DTXSID9020794 Css NA 4.412 mg/L PBTK NA 95% Human Human +DTXSID9020794 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020794 Fup 0.459 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020794 Vd NA 0.6099 L/kg 1compartment NA NA Rat Human DTXSID9020794 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020794 TK.Half.Life NA 2.392 hours 1compartment NA NA Rat Human -DTXSID9020794 Css NA 0.1056 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020794 Css NA 0.8671 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020794 Css NA 0.09698 mg/L PBTK NA 50% Rat Human -DTXSID9020794 Css NA 0.5338 mg/L PBTK NA 95% Rat Human -DTXSID9020796 Clint NA 362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020796 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020796 Vd NA 2.02 L/kg 1compartment NA NA Human Human -DTXSID9020796 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020796 TK.Half.Life NA 3.326 hours 1compartment NA NA Human Human -DTXSID9020796 Css NA 0.1281 mg/L 3compartmentss NA 50% Human Human -DTXSID9020796 Css NA 1.092 mg/L 3compartmentss NA 95% Human Human -DTXSID9020796 Css NA 0.0827 mg/L PBTK NA 50% Human Human -DTXSID9020796 Css NA 0.6737 mg/L PBTK NA 95% Human Human -DTXSID9020796 Clint NA 362 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020796 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020796 Vd NA 1.499 L/kg 1compartment NA NA Rat Human -DTXSID9020796 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020796 TK.Half.Life NA 1.076 hours 1compartment NA NA Rat Human -DTXSID9020796 Css NA 0.07244 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020796 Css NA 0.5446 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020796 Css NA 0.04392 mg/L PBTK NA 50% Rat Human -DTXSID9020796 Css NA 0.3165 mg/L PBTK NA 95% Rat Human -DTXSID9020821 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020821 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020821 Vd NA 0.7316 L/kg 1compartment NA NA Human Human +DTXSID9020794 TK.Half.Life NA 2.93 hours 1compartment NA NA Rat Human +DTXSID9020794 Css NA 0.09464 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020794 Css NA 0.3826 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020794 Css NA 0.07212 mg/L PBTK NA 50% Rat Human +DTXSID9020794 Css NA 0.2374 mg/L PBTK NA 95% Rat Human +DTXSID9020796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020796 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020796 Vd NA 3.065 L/kg 1compartment NA NA Human Human +DTXSID9020796 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9020796 TK.Half.Life NA 38.34 hours 1compartment NA NA Human Human +DTXSID9020796 Css NA 1.424 mg/L 3compartmentss NA 50% Human Human +DTXSID9020796 Css NA 9.243 mg/L 3compartmentss NA 95% Human Human +DTXSID9020796 Css NA 0.9982 mg/L PBTK NA 50% Human Human +DTXSID9020796 Css NA 6.219 mg/L PBTK NA 95% Human Human +DTXSID9020796 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020796 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020796 Vd NA 2.3 L/kg 1compartment NA NA Rat Human +DTXSID9020796 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9020796 TK.Half.Life NA 5.844 hours 1compartment NA NA Rat Human +DTXSID9020796 Css NA 0.1838 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020796 Css NA 1.004 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020796 Css NA 0.1273 mg/L PBTK NA 50% Rat Human +DTXSID9020796 Css NA 0.6888 mg/L PBTK NA 95% Rat Human +DTXSID9020821 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020821 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020821 Vd NA 0.3904 L/kg 1compartment NA NA Human Human DTXSID9020821 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020821 TK.Half.Life NA 4.735 hours 1compartment NA NA Human Human -DTXSID9020821 Css NA 0.8408 mg/L 3compartmentss NA 50% Human Human -DTXSID9020821 Css NA 5.533 mg/L 3compartmentss NA 95% Human Human -DTXSID9020821 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID9020821 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID9020821 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020821 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020821 Vd NA 0.777 L/kg 1compartment NA NA Rat Human +DTXSID9020821 TK.Half.Life NA 3.629 hours 1compartment NA NA Human Human +DTXSID9020821 Css NA 1.05 mg/L 3compartmentss NA 50% Human Human +DTXSID9020821 Css NA 6.299 mg/L 3compartmentss NA 95% Human Human +DTXSID9020821 Css NA 0.7504 mg/L PBTK NA 50% Human Human +DTXSID9020821 Css NA 3.913 mg/L PBTK NA 95% Human Human +DTXSID9020821 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020821 Fup 0.696 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020821 Vd NA 0.4137 L/kg 1compartment NA NA Rat Human DTXSID9020821 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020821 TK.Half.Life NA 1.713 hours 1compartment NA NA Rat Human -DTXSID9020821 Css NA 0.2112 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020821 Css NA 1.313 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020821 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID9020821 Css NA 0.7874 mg/L PBTK NA 95% Rat Human -DTXSID9020825 Clint NA 92.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020825 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020825 Vd NA 1.058 L/kg 1compartment NA NA Human Human +DTXSID9020821 TK.Half.Life NA 1.311 hours 1compartment NA NA Rat Human +DTXSID9020821 Css NA 0.0204 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020821 Css NA 0.1578 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020821 Css NA 0.01391 mg/L PBTK NA 50% Rat Human +DTXSID9020821 Css NA 0.09307 mg/L PBTK NA 95% Rat Human +DTXSID9020825 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020825 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020825 Vd NA 2.353 L/kg 1compartment NA NA Human Human DTXSID9020825 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020825 TK.Half.Life NA 1.634 hours 1compartment NA NA Human Human -DTXSID9020825 Css NA 0.114 mg/L 3compartmentss NA 50% Human Human -DTXSID9020825 Css NA 0.9777 mg/L 3compartmentss NA 95% Human Human -DTXSID9020825 Css NA 0.07209 mg/L PBTK NA 50% Human Human -DTXSID9020825 Css NA 0.5858 mg/L PBTK NA 95% Human Human -DTXSID9020825 Clint NA 92.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020825 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020825 Vd NA 0.8124 L/kg 1compartment NA NA Rat Human +DTXSID9020825 TK.Half.Life NA 7.343 hours 1compartment NA NA Human Human +DTXSID9020825 Css NA 0.3148 mg/L 3compartmentss NA 50% Human Human +DTXSID9020825 Css NA 2.184 mg/L 3compartmentss NA 95% Human Human +DTXSID9020825 Css NA 0.22 mg/L PBTK NA 50% Human Human +DTXSID9020825 Css NA 1.452 mg/L PBTK NA 95% Human Human +DTXSID9020825 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020825 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020825 Vd NA 1.784 L/kg 1compartment NA NA Rat Human DTXSID9020825 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020825 TK.Half.Life NA 0.6436 hours 1compartment NA NA Rat Human -DTXSID9020825 Css NA 0.06596 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020825 Css NA 0.4274 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020825 Css NA 0.03914 mg/L PBTK NA 50% Rat Human -DTXSID9020825 Css NA 0.2417 mg/L PBTK NA 95% Rat Human +DTXSID9020825 TK.Half.Life NA 2.134 hours 1compartment NA NA Rat Human +DTXSID9020825 Css NA 0.03993 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020825 Css NA 0.2101 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020825 Css NA 0.02752 mg/L PBTK NA 50% Rat Human +DTXSID9020825 Css NA 0.1365 mg/L PBTK NA 95% Rat Human DTXSID9020827 Clint 12.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020827 Fup 0.0171 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9020827 Vd NA 3.011 L/kg 1compartment NA NA Human Human DTXSID9020827 Days.Css NA 19 Days PBTK NA NA Human Human DTXSID9020827 TK.Half.Life NA 111.7 hours 1compartment NA NA Human Human -DTXSID9020827 Css NA 4.55 mg/L 3compartmentss NA 50% Human Human -DTXSID9020827 Css NA 29.12 mg/L 3compartmentss NA 95% Human Human -DTXSID9020827 Css NA 3.16 mg/L PBTK NA 50% Human Human -DTXSID9020827 Css NA 19.32 mg/L PBTK NA 95% Human Human +DTXSID9020827 Css NA 4.382 mg/L 3compartmentss NA 50% Human Human +DTXSID9020827 Css NA 28.52 mg/L 3compartmentss NA 95% Human Human +DTXSID9020827 Css NA 3.035 mg/L PBTK NA 50% Human Human +DTXSID9020827 Css NA 19.18 mg/L PBTK NA 95% Human Human DTXSID9020827 Clint 12.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020827 Fup 0.0171 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9020827 Vd NA 2.254 L/kg 1compartment NA NA Rat Human DTXSID9020827 Days.Css NA 11 Days PBTK NA NA Rat Human DTXSID9020827 TK.Half.Life NA 17.11 hours 1compartment NA NA Rat Human -DTXSID9020827 Css NA 2.56 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020827 Css NA 13.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020827 Css NA 1.686 mg/L PBTK NA 50% Rat Human -DTXSID9020827 Css NA 8.617 mg/L PBTK NA 95% Rat Human +DTXSID9020827 Css NA 0.5754 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020827 Css NA 3.179 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020827 Css NA 0.3938 mg/L PBTK NA 50% Rat Human +DTXSID9020827 Css NA 2.139 mg/L PBTK NA 95% Rat Human +DTXSID9020829 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020829 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020829 Vd NA 0.4111 L/kg 1compartment NA NA Human Human +DTXSID9020829 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9020829 TK.Half.Life NA 0.9839 hours 1compartment NA NA Human Human +DTXSID9020829 Css NA 0.212 mg/L 3compartmentss NA 50% Human Human +DTXSID9020829 Css NA 1.29 mg/L 3compartmentss NA 95% Human Human +DTXSID9020829 Css NA 0.1468 mg/L PBTK NA 50% Human Human +DTXSID9020829 Css NA 0.8377 mg/L PBTK NA 95% Human Human +DTXSID9020829 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020829 Fup 0.327 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020829 Vd NA 0.4123 L/kg 1compartment NA NA Rat Human +DTXSID9020829 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9020829 TK.Half.Life NA 0.559 hours 1compartment NA NA Rat Human +DTXSID9020829 Css NA 0.02446 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020829 Css NA 0.1163 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020829 Css NA 0.01687 mg/L PBTK NA 50% Rat Human +DTXSID9020829 Css NA 0.0724 mg/L PBTK NA 95% Rat Human DTXSID9020875 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9020875 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020875 Vd NA 0.5069 L/kg 1compartment NA NA Human Human -DTXSID9020875 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020875 TK.Half.Life NA 5.854 hours 1compartment NA NA Human Human -DTXSID9020875 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human -DTXSID9020875 Css NA 9.631 mg/L 3compartmentss NA 95% Human Human -DTXSID9020875 Css NA 1.035 mg/L PBTK NA 50% Human Human -DTXSID9020875 Css NA 5.926 mg/L PBTK NA 95% Human Human +DTXSID9020875 Vd NA 0.9882 L/kg 1compartment NA NA Human Human +DTXSID9020875 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9020875 TK.Half.Life NA 11.41 hours 1compartment NA NA Human Human +DTXSID9020875 Css NA 1.048 mg/L 3compartmentss NA 50% Human Human +DTXSID9020875 Css NA 7.611 mg/L 3compartmentss NA 95% Human Human +DTXSID9020875 Css NA 0.8733 mg/L PBTK NA 50% Human Human +DTXSID9020875 Css NA 4.817 mg/L PBTK NA 95% Human Human DTXSID9020875 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9020875 Fup NA 0.5602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020875 Vd NA 0.5402 L/kg 1compartment NA NA Rat Human +DTXSID9020875 Vd NA 1.009 L/kg 1compartment NA NA Rat Human DTXSID9020875 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020875 TK.Half.Life NA 2.126 hours 1compartment NA NA Rat Human -DTXSID9020875 Css NA 0.3649 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020875 Css NA 2.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020875 Css NA 0.262 mg/L PBTK NA 50% Rat Human -DTXSID9020875 Css NA 1.296 mg/L PBTK NA 95% Rat Human -DTXSID9020902 Clint NA 6.691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020902 Fup NA 0.7253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020902 Vd NA 2.098 L/kg 1compartment NA NA Human Human -DTXSID9020902 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020902 TK.Half.Life NA 2.4 hours 1compartment NA NA Human Human -DTXSID9020902 Css NA 0.0759 mg/L 3compartmentss NA 50% Human Human -DTXSID9020902 Css NA 0.6933 mg/L 3compartmentss NA 95% Human Human -DTXSID9020902 Css NA 0.07664 mg/L PBTK NA 50% Human Human -DTXSID9020902 Css NA 0.5238 mg/L PBTK NA 95% Human Human -DTXSID9020902 Clint NA 6.691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020902 Fup NA 0.7253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020902 Vd NA 2.126 L/kg 1compartment NA NA Rat Human +DTXSID9020875 TK.Half.Life NA 3.972 hours 1compartment NA NA Rat Human +DTXSID9020875 Css NA 0.01982 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020875 Css NA 0.1893 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020875 Css NA 0.01597 mg/L PBTK NA 50% Rat Human +DTXSID9020875 Css NA 0.1206 mg/L PBTK NA 95% Rat Human +DTXSID9020902 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020902 Fup 0.652 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020902 Vd NA 1.911 L/kg 1compartment NA NA Human Human +DTXSID9020902 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9020902 TK.Half.Life NA 18.96 hours 1compartment NA NA Human Human +DTXSID9020902 Css NA 0.5034 mg/L 3compartmentss NA 50% Human Human +DTXSID9020902 Css NA 3.885 mg/L 3compartmentss NA 95% Human Human +DTXSID9020902 Css NA 0.5067 mg/L PBTK NA 50% Human Human +DTXSID9020902 Css NA 2.673 mg/L PBTK NA 95% Human Human +DTXSID9020902 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020902 Fup 0.652 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020902 Vd NA 1.934 L/kg 1compartment NA NA Rat Human DTXSID9020902 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020902 TK.Half.Life NA 1.33 hours 1compartment NA NA Rat Human -DTXSID9020902 Css NA 0.03593 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020902 Css NA 0.3077 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020902 Css NA 0.03654 mg/L PBTK NA 50% Rat Human -DTXSID9020902 Css NA 0.2079 mg/L PBTK NA 95% Rat Human -DTXSID9020956 Clint NA 0.1348 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020956 Fup NA 0.1681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020956 Vd NA 0.3206 L/kg 1compartment NA NA Human Human -DTXSID9020956 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9020956 TK.Half.Life NA 10.07 hours 1compartment NA NA Human Human -DTXSID9020956 Css NA 3.887 mg/L 3compartmentss NA 50% Human Human -DTXSID9020956 Css NA 14.03 mg/L 3compartmentss NA 95% Human Human -DTXSID9020956 Css NA 2.53 mg/L PBTK NA 50% Human Human -DTXSID9020956 Css NA 8.487 mg/L PBTK NA 95% Human Human -DTXSID9020956 Clint NA 0.1348 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020956 Fup NA 0.1681 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020956 Vd NA 0.3203 L/kg 1compartment NA NA Rat Human -DTXSID9020956 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020956 TK.Half.Life NA 3.788 hours 1compartment NA NA Rat Human -DTXSID9020956 Css NA 1.217 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020956 Css NA 3.828 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020956 Css NA 0.7459 mg/L PBTK NA 50% Rat Human -DTXSID9020956 Css NA 2.167 mg/L PBTK NA 95% Rat Human -DTXSID9020958 Clint NA 3.598 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020958 Fup NA 0.7426 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9020958 Vd NA 1.081 L/kg 1compartment NA NA Human Human +DTXSID9020902 TK.Half.Life NA 6.539 hours 1compartment NA NA Rat Human +DTXSID9020902 Css NA 0.002566 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020902 Css NA 0.02107 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020902 Css NA 0.002539 mg/L PBTK NA 50% Rat Human +DTXSID9020902 Css NA 0.01415 mg/L PBTK NA 95% Rat Human +DTXSID90209085 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90209085 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90209085 Vd NA 0.2853 L/kg 1compartment NA NA Human Human +DTXSID90209085 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90209085 TK.Half.Life NA 8.055 hours 1compartment NA NA Human Human +DTXSID90209085 Css NA 4.506 mg/L 3compartmentss NA 50% Human Human +DTXSID90209085 Css NA 38.23 mg/L 3compartmentss NA 95% Human Human +DTXSID90209085 Css NA 2.647 mg/L PBTK NA 50% Human Human +DTXSID90209085 Css NA 22.28 mg/L PBTK NA 95% Human Human +DTXSID90209085 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90209085 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90209085 Vd NA 0.2446 L/kg 1compartment NA NA Rat Human +DTXSID90209085 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90209085 TK.Half.Life NA 4.373 hours 1compartment NA NA Rat Human +DTXSID90209085 Css NA 0.2073 mg/L 3compartmentss NA 50% Rat Human +DTXSID90209085 Css NA 1.959 mg/L 3compartmentss NA 95% Rat Human +DTXSID90209085 Css NA 0.1158 mg/L PBTK NA 50% Rat Human +DTXSID90209085 Css NA 1.092 mg/L PBTK NA 95% Rat Human +DTXSID9020958 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020958 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9020958 Vd NA 0.7767 L/kg 1compartment NA NA Human Human DTXSID9020958 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9020958 TK.Half.Life NA 1.854 hours 1compartment NA NA Human Human -DTXSID9020958 Css NA 0.1521 mg/L 3compartmentss NA 50% Human Human -DTXSID9020958 Css NA 1.21 mg/L 3compartmentss NA 95% Human Human -DTXSID9020958 Css NA 0.1312 mg/L PBTK NA 50% Human Human -DTXSID9020958 Css NA 0.8371 mg/L PBTK NA 95% Human Human -DTXSID9020958 Clint NA 3.598 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020958 Fup NA 0.7426 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9020958 Vd NA 1.024 L/kg 1compartment NA NA Rat Human +DTXSID9020958 TK.Half.Life NA 0.8376 hours 1compartment NA NA Human Human +DTXSID9020958 Css NA 0.04512 mg/L 3compartmentss NA 50% Human Human +DTXSID9020958 Css NA 0.3763 mg/L 3compartmentss NA 95% Human Human +DTXSID9020958 Css NA 0.03452 mg/L PBTK NA 50% Human Human +DTXSID9020958 Css NA 0.2601 mg/L PBTK NA 95% Human Human +DTXSID9020958 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020958 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9020958 Vd NA 0.7325 L/kg 1compartment NA NA Rat Human DTXSID9020958 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9020958 TK.Half.Life NA 0.9244 hours 1compartment NA NA Rat Human -DTXSID9020958 Css NA 0.06716 mg/L 3compartmentss NA 50% Rat Human -DTXSID9020958 Css NA 0.5094 mg/L 3compartmentss NA 95% Rat Human -DTXSID9020958 Css NA 0.05754 mg/L PBTK NA 50% Rat Human -DTXSID9020958 Css NA 0.3168 mg/L PBTK NA 95% Rat Human -DTXSID9021053 Clint NA 104.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021053 Fup NA 0.6606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021053 Vd NA 1.247 L/kg 1compartment NA NA Human Human +DTXSID9020958 TK.Half.Life NA 0.4032 hours 1compartment NA NA Rat Human +DTXSID9020958 Css NA 0.005576 mg/L 3compartmentss NA 50% Rat Human +DTXSID9020958 Css NA 0.0369 mg/L 3compartmentss NA 95% Rat Human +DTXSID9020958 Css NA 0.00429 mg/L PBTK NA 50% Rat Human +DTXSID9020958 Css NA 0.02466 mg/L PBTK NA 95% Rat Human +DTXSID90210035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90210035 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90210035 Vd NA 3.095 L/kg 1compartment NA NA Human Human +DTXSID90210035 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID90210035 TK.Half.Life NA 81.82 hours 1compartment NA NA Human Human +DTXSID90210035 Css NA 3.17 mg/L 3compartmentss NA 50% Human Human +DTXSID90210035 Css NA 20.49 mg/L 3compartmentss NA 95% Human Human +DTXSID90210035 Css NA 2.192 mg/L PBTK NA 50% Human Human +DTXSID90210035 Css NA 13.85 mg/L PBTK NA 95% Human Human +DTXSID90210035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90210035 Fup 0.019 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90210035 Vd NA 2.319 L/kg 1compartment NA NA Rat Human +DTXSID90210035 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID90210035 TK.Half.Life NA 11.43 hours 1compartment NA NA Rat Human +DTXSID90210035 Css NA 0.4082 mg/L 3compartmentss NA 50% Rat Human +DTXSID90210035 Css NA 2.247 mg/L 3compartmentss NA 95% Rat Human +DTXSID90210035 Css NA 0.2812 mg/L PBTK NA 50% Rat Human +DTXSID90210035 Css NA 1.491 mg/L PBTK NA 95% Rat Human +DTXSID9021053 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021053 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021053 Vd NA 1.125 L/kg 1compartment NA NA Human Human DTXSID9021053 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021053 TK.Half.Life NA 0.8018 hours 1compartment NA NA Human Human -DTXSID9021053 Css NA 0.006852 mg/L 3compartmentss NA 50% Human Human -DTXSID9021053 Css NA 0.07681 mg/L 3compartmentss NA 95% Human Human -DTXSID9021053 Css NA 0.005893 mg/L PBTK NA 50% Human Human -DTXSID9021053 Css NA 0.05553 mg/L PBTK NA 95% Human Human -DTXSID9021053 Clint NA 104.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021053 Fup NA 0.6606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021053 Vd NA 1.127 L/kg 1compartment NA NA Rat Human +DTXSID9021053 TK.Half.Life NA 1.148 hours 1compartment NA NA Human Human +DTXSID9021053 Css NA 0.04088 mg/L 3compartmentss NA 50% Human Human +DTXSID9021053 Css NA 0.349 mg/L 3compartmentss NA 95% Human Human +DTXSID9021053 Css NA 0.03289 mg/L PBTK NA 50% Human Human +DTXSID9021053 Css NA 0.2492 mg/L PBTK NA 95% Human Human +DTXSID9021053 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021053 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021053 Vd NA 0.9945 L/kg 1compartment NA NA Rat Human DTXSID9021053 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021053 TK.Half.Life NA 0.3234 hours 1compartment NA NA Rat Human -DTXSID9021053 Css NA 0.003576 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021053 Css NA 0.03645 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021053 Css NA 0.003028 mg/L PBTK NA 50% Rat Human -DTXSID9021053 Css NA 0.02459 mg/L PBTK NA 95% Rat Human -DTXSID9021059 Clint NA 0.1458 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021059 Fup NA 0.7771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021059 Vd NA 0.9904 L/kg 1compartment NA NA Human Human +DTXSID9021053 TK.Half.Life NA 0.5059 hours 1compartment NA NA Rat Human +DTXSID9021053 Css NA 0.00509 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021053 Css NA 0.03516 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021053 Css NA 0.00411 mg/L PBTK NA 50% Rat Human +DTXSID9021053 Css NA 0.02462 mg/L PBTK NA 95% Rat Human +DTXSID9021059 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021059 Fup 0.724 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021059 Vd NA 0.9475 L/kg 1compartment NA NA Human Human DTXSID9021059 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021059 TK.Half.Life NA 6.717 hours 1compartment NA NA Human Human -DTXSID9021059 Css NA 0.7585 mg/L 3compartmentss NA 50% Human Human -DTXSID9021059 Css NA 4.626 mg/L 3compartmentss NA 95% Human Human -DTXSID9021059 Css NA 0.6556 mg/L PBTK NA 50% Human Human -DTXSID9021059 Css NA 3.033 mg/L PBTK NA 95% Human Human -DTXSID9021059 Clint NA 0.1458 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021059 Fup NA 0.7771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021059 Vd NA 0.9941 L/kg 1compartment NA NA Rat Human +DTXSID9021059 TK.Half.Life NA 8.53 hours 1compartment NA NA Human Human +DTXSID9021059 Css NA 0.9947 mg/L 3compartmentss NA 50% Human Human +DTXSID9021059 Css NA 6.445 mg/L 3compartmentss NA 95% Human Human +DTXSID9021059 Css NA 0.8404 mg/L PBTK NA 50% Human Human +DTXSID9021059 Css NA 4.214 mg/L PBTK NA 95% Human Human +DTXSID9021059 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021059 Fup 0.724 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021059 Vd NA 0.9507 L/kg 1compartment NA NA Rat Human DTXSID9021059 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021059 TK.Half.Life NA 2.533 hours 1compartment NA NA Rat Human -DTXSID9021059 Css NA 0.2202 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021059 Css NA 1.432 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021059 Css NA 0.1846 mg/L PBTK NA 50% Rat Human -DTXSID9021059 Css NA 0.8654 mg/L PBTK NA 95% Rat Human -DTXSID9021130 Clint NA 1.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9021059 TK.Half.Life NA 2.9 hours 1compartment NA NA Rat Human +DTXSID9021059 Css NA 0.05931 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021059 Css NA 0.3814 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021059 Css NA 0.05056 mg/L PBTK NA 50% Rat Human +DTXSID9021059 Css NA 0.2373 mg/L PBTK NA 95% Rat Human +DTXSID9021130 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID9021130 Fup 0.89 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9021130 Vd NA 2.003 L/kg 1compartment NA NA Human Human +DTXSID9021130 Vd NA 1.448 L/kg 1compartment NA NA Human Human DTXSID9021130 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021130 TK.Half.Life NA 5.929 hours 1compartment NA NA Human Human -DTXSID9021130 Css NA 0.2655 mg/L 3compartmentss NA 50% Human Human -DTXSID9021130 Css NA 1.748 mg/L 3compartmentss NA 95% Human Human -DTXSID9021130 Css NA 0.2523 mg/L PBTK NA 50% Human Human -DTXSID9021130 Css NA 1.267 mg/L PBTK NA 95% Human Human -DTXSID9021130 Clint NA 1.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9021130 TK.Half.Life NA 3.118 hours 1compartment NA NA Human Human +DTXSID9021130 Css NA 0.2002 mg/L 3compartmentss NA 50% Human Human +DTXSID9021130 Css NA 1.494 mg/L 3compartmentss NA 95% Human Human +DTXSID9021130 Css NA 0.1846 mg/L PBTK NA 50% Human Human +DTXSID9021130 Css NA 1.047 mg/L PBTK NA 95% Human Human +DTXSID9021130 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID9021130 Fup 0.89 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9021130 Vd NA 1.704 L/kg 1compartment NA NA Rat Human +DTXSID9021130 Vd NA 1.32 L/kg 1compartment NA NA Rat Human DTXSID9021130 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021130 TK.Half.Life NA 2.092 hours 1compartment NA NA Rat Human -DTXSID9021130 Css NA 0.1092 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021130 Css NA 0.6567 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021130 Css NA 0.103 mg/L PBTK NA 50% Rat Human -DTXSID9021130 Css NA 0.4312 mg/L PBTK NA 95% Rat Human -DTXSID9021132 Clint NA 11.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021132 Fup NA 0.1096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021132 Vd NA 1.485 L/kg 1compartment NA NA Human Human +DTXSID9021130 TK.Half.Life NA 1.386 hours 1compartment NA NA Rat Human +DTXSID9021130 Css NA 0.01944 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021130 Css NA 0.1236 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021130 Css NA 0.0184 mg/L PBTK NA 50% Rat Human +DTXSID9021130 Css NA 0.08188 mg/L PBTK NA 95% Rat Human +DTXSID9021132 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021132 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021132 Vd NA 1.037 L/kg 1compartment NA NA Human Human DTXSID9021132 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021132 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human -DTXSID9021132 Css NA 0.5168 mg/L 3compartmentss NA 50% Human Human -DTXSID9021132 Css NA 3.726 mg/L 3compartmentss NA 95% Human Human -DTXSID9021132 Css NA 0.3462 mg/L PBTK NA 50% Human Human -DTXSID9021132 Css NA 2.352 mg/L PBTK NA 95% Human Human -DTXSID9021132 Clint NA 11.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021132 Fup NA 0.1096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021132 Vd NA 1.141 L/kg 1compartment NA NA Rat Human +DTXSID9021132 TK.Half.Life NA 1.951 hours 1compartment NA NA Human Human +DTXSID9021132 Css NA 0.1362 mg/L 3compartmentss NA 50% Human Human +DTXSID9021132 Css NA 0.982 mg/L 3compartmentss NA 95% Human Human +DTXSID9021132 Css NA 0.09342 mg/L PBTK NA 50% Human Human +DTXSID9021132 Css NA 0.6377 mg/L PBTK NA 95% Human Human +DTXSID9021132 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021132 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021132 Vd NA 0.8399 L/kg 1compartment NA NA Rat Human DTXSID9021132 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021132 TK.Half.Life NA 2.422 hours 1compartment NA NA Rat Human -DTXSID9021132 Css NA 0.2838 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021132 Css NA 1.478 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021132 Css NA 0.1794 mg/L PBTK NA 50% Rat Human -DTXSID9021132 Css NA 0.874 mg/L PBTK NA 95% Rat Human -DTXSID9021134 Clint NA 0.7535 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021134 Fup NA 0.7116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021134 Vd NA 0.9746 L/kg 1compartment NA NA Human Human +DTXSID9021132 TK.Half.Life NA 0.8489 hours 1compartment NA NA Rat Human +DTXSID9021132 Css NA 0.01756 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021132 Css NA 0.09382 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021132 Css NA 0.0119 mg/L PBTK NA 50% Rat Human +DTXSID9021132 Css NA 0.06004 mg/L PBTK NA 95% Rat Human +DTXSID9021134 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021134 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021134 Vd NA 0.6708 L/kg 1compartment NA NA Human Human DTXSID9021134 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021134 TK.Half.Life NA 4.209 hours 1compartment NA NA Human Human -DTXSID9021134 Css NA 0.461 mg/L 3compartmentss NA 50% Human Human -DTXSID9021134 Css NA 3.002 mg/L 3compartmentss NA 95% Human Human -DTXSID9021134 Css NA 0.3938 mg/L PBTK NA 50% Human Human -DTXSID9021134 Css NA 1.975 mg/L PBTK NA 95% Human Human -DTXSID9021134 Clint NA 0.7535 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021134 Fup NA 0.7116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021134 Vd NA 0.9386 L/kg 1compartment NA NA Rat Human +DTXSID9021134 TK.Half.Life NA 0.7761 hours 1compartment NA NA Human Human +DTXSID9021134 Css NA 0.05179 mg/L 3compartmentss NA 50% Human Human +DTXSID9021134 Css NA 0.407 mg/L 3compartmentss NA 95% Human Human +DTXSID9021134 Css NA 0.03858 mg/L PBTK NA 50% Human Human +DTXSID9021134 Css NA 0.2713 mg/L PBTK NA 95% Human Human +DTXSID9021134 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021134 Fup 0.377 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021134 Vd NA 0.6428 L/kg 1compartment NA NA Rat Human DTXSID9021134 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021134 TK.Half.Life NA 1.852 hours 1compartment NA NA Rat Human -DTXSID9021134 Css NA 0.164 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021134 Css NA 1.171 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021134 Css NA 0.1381 mg/L PBTK NA 50% Rat Human -DTXSID9021134 Css NA 0.7004 mg/L PBTK NA 95% Rat Human -DTXSID9021136 Clint NA 0.4437 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021136 Fup NA 0.0174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021136 Vd NA 0.2137 L/kg 1compartment NA NA Human Human -DTXSID9021136 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID9021136 TK.Half.Life NA 45.72 hours 1compartment NA NA Human Human -DTXSID9021136 Css NA 36.02 mg/L 3compartmentss NA 50% Human Human -DTXSID9021136 Css NA 239.4 mg/L 3compartmentss NA 95% Human Human -DTXSID9021136 Css NA 21.36 mg/L PBTK NA 50% Human Human -DTXSID9021136 Css NA 136.4 mg/L PBTK NA 95% Human Human -DTXSID9021136 Clint NA 0.4437 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021136 Fup NA 0.0174 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021136 Vd NA 0.2062 L/kg 1compartment NA NA Rat Human -DTXSID9021136 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9021136 TK.Half.Life NA 19.23 hours 1compartment NA NA Rat Human -DTXSID9021136 Css NA 13.36 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021136 Css NA 76.75 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021136 Css NA 7.376 mg/L PBTK NA 50% Rat Human -DTXSID9021136 Css NA 41.59 mg/L PBTK NA 95% Rat Human -DTXSID9021138 Clint NA 4.331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021138 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021138 Vd NA 0.9029 L/kg 1compartment NA NA Human Human +DTXSID9021134 TK.Half.Life NA 0.3849 hours 1compartment NA NA Rat Human +DTXSID9021134 Css NA 0.006434 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021134 Css NA 0.03919 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021134 Css NA 0.004794 mg/L PBTK NA 50% Rat Human +DTXSID9021134 Css NA 0.02573 mg/L PBTK NA 95% Rat Human +DTXSID9021136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021136 Fup 0.0414 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021136 Vd NA 1.524 L/kg 1compartment NA NA Human Human +DTXSID9021136 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9021136 TK.Half.Life NA 8.266 hours 1compartment NA NA Human Human +DTXSID9021136 Css NA 0.7739 mg/L 3compartmentss NA 50% Human Human +DTXSID9021136 Css NA 6.507 mg/L 3compartmentss NA 95% Human Human +DTXSID9021136 Css NA 0.4918 mg/L PBTK NA 50% Human Human +DTXSID9021136 Css NA 3.982 mg/L PBTK NA 95% Human Human +DTXSID9021136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021136 Fup 0.0414 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021136 Vd NA 1.141 L/kg 1compartment NA NA Rat Human +DTXSID9021136 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9021136 TK.Half.Life NA 3.164 hours 1compartment NA NA Rat Human +DTXSID9021136 Css NA 0.1013 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021136 Css NA 0.6578 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021136 Css NA 0.06276 mg/L PBTK NA 50% Rat Human +DTXSID9021136 Css NA 0.3837 mg/L PBTK NA 95% Rat Human +DTXSID9021138 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021138 Fup 0.636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021138 Vd NA 0.6862 L/kg 1compartment NA NA Human Human DTXSID9021138 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021138 TK.Half.Life NA 1.096 hours 1compartment NA NA Human Human -DTXSID9021138 Css NA 0.1034 mg/L 3compartmentss NA 50% Human Human -DTXSID9021138 Css NA 0.9068 mg/L 3compartmentss NA 95% Human Human -DTXSID9021138 Css NA 0.08844 mg/L PBTK NA 50% Human Human -DTXSID9021138 Css NA 0.6512 mg/L PBTK NA 95% Human Human -DTXSID9021138 Clint NA 4.331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021138 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021138 Vd NA 0.9256 L/kg 1compartment NA NA Rat Human +DTXSID9021138 TK.Half.Life NA 6.997 hours 1compartment NA NA Human Human +DTXSID9021138 Css NA 0.988 mg/L 3compartmentss NA 50% Human Human +DTXSID9021138 Css NA 6.449 mg/L 3compartmentss NA 95% Human Human +DTXSID9021138 Css NA 0.8005 mg/L PBTK NA 50% Human Human +DTXSID9021138 Css NA 4.168 mg/L PBTK NA 95% Human Human +DTXSID9021138 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021138 Fup 0.636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021138 Vd NA 0.7017 L/kg 1compartment NA NA Rat Human DTXSID9021138 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021138 TK.Half.Life NA 0.5879 hours 1compartment NA NA Rat Human -DTXSID9021138 Css NA 0.04708 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021138 Css NA 0.3278 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021138 Css NA 0.0401 mg/L PBTK NA 50% Rat Human -DTXSID9021138 Css NA 0.2143 mg/L PBTK NA 95% Rat Human +DTXSID9021138 TK.Half.Life NA 2.433 hours 1compartment NA NA Rat Human +DTXSID9021138 Css NA 0.01922 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021138 Css NA 0.1588 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021138 Css NA 0.01476 mg/L PBTK NA 50% Rat Human +DTXSID9021138 Css NA 0.0994 mg/L PBTK NA 95% Rat Human +DTXSID90211380 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90211380 Fup 0.0833 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90211380 Vd NA 1.155 L/kg 1compartment NA NA Human Human +DTXSID90211380 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90211380 TK.Half.Life NA 3.513 hours 1compartment NA NA Human Human +DTXSID90211380 Css NA 0.3491 mg/L 3compartmentss NA 50% Human Human +DTXSID90211380 Css NA 2.787 mg/L 3compartmentss NA 95% Human Human +DTXSID90211380 Css NA 0.2247 mg/L PBTK NA 50% Human Human +DTXSID90211380 Css NA 1.686 mg/L PBTK NA 95% Human Human +DTXSID90211380 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90211380 Fup 0.0833 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90211380 Vd NA 0.8939 L/kg 1compartment NA NA Rat Human +DTXSID90211380 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90211380 TK.Half.Life NA 1.488 hours 1compartment NA NA Rat Human +DTXSID90211380 Css NA 0.04184 mg/L 3compartmentss NA 50% Rat Human +DTXSID90211380 Css NA 0.2467 mg/L 3compartmentss NA 95% Rat Human +DTXSID90211380 Css NA 0.02638 mg/L PBTK NA 50% Rat Human +DTXSID90211380 Css NA 0.1465 mg/L PBTK NA 95% Rat Human DTXSID9021182 Clint 17.38 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID9021182 Fup NA 0.2093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021182 Vd NA 0.9128 L/kg 1compartment NA NA Human Human +DTXSID9021182 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021182 Vd NA 1.595 L/kg 1compartment NA NA Human Human DTXSID9021182 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021182 TK.Half.Life NA 1.654 hours 1compartment NA NA Human Human -DTXSID9021182 Css NA 0.1355 mg/L 3compartmentss NA 50% Human Human -DTXSID9021182 Css NA 0.8518 mg/L 3compartmentss NA 95% Human Human -DTXSID9021182 Css NA 0.09468 mg/L PBTK NA 50% Human Human -DTXSID9021182 Css NA 0.5726 mg/L PBTK NA 95% Human Human +DTXSID9021182 TK.Half.Life NA 3.197 hours 1compartment NA NA Human Human +DTXSID9021182 Css NA 0.1481 mg/L 3compartmentss NA 50% Human Human +DTXSID9021182 Css NA 1.055 mg/L 3compartmentss NA 95% Human Human +DTXSID9021182 Css NA 0.1073 mg/L PBTK NA 50% Human Human +DTXSID9021182 Css NA 0.7041 mg/L PBTK NA 95% Human Human DTXSID9021182 Clint 17.38 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID9021182 Fup NA 0.2093 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021182 Vd NA 0.7688 L/kg 1compartment NA NA Rat Human +DTXSID9021182 Fup 0.209 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021182 Vd NA 1.255 L/kg 1compartment NA NA Rat Human DTXSID9021182 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021182 TK.Half.Life NA 0.7584 hours 1compartment NA NA Rat Human -DTXSID9021182 Css NA 0.07184 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021182 Css NA 0.3707 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021182 Css NA 0.04814 mg/L PBTK NA 50% Rat Human -DTXSID9021182 Css NA 0.2313 mg/L PBTK NA 95% Rat Human +DTXSID9021182 TK.Half.Life NA 1.235 hours 1compartment NA NA Rat Human +DTXSID9021182 Css NA 0.01886 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021182 Css NA 0.0934 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021182 Css NA 0.01357 mg/L PBTK NA 50% Rat Human +DTXSID9021182 Css NA 0.06225 mg/L PBTK NA 95% Rat Human DTXSID9021184 Clint 5.841 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID9021184 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9021184 Vd NA 0.9342 L/kg 1compartment NA NA Human Human DTXSID9021184 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9021184 TK.Half.Life NA 2.759 hours 1compartment NA NA Human Human -DTXSID9021184 Css NA 0.2264 mg/L 3compartmentss NA 50% Human Human -DTXSID9021184 Css NA 1.425 mg/L 3compartmentss NA 95% Human Human -DTXSID9021184 Css NA 0.218 mg/L PBTK NA 50% Human Human -DTXSID9021184 Css NA 1.135 mg/L PBTK NA 95% Human Human +DTXSID9021184 Css NA 0.2068 mg/L 3compartmentss NA 50% Human Human +DTXSID9021184 Css NA 1.183 mg/L 3compartmentss NA 95% Human Human +DTXSID9021184 Css NA 0.2062 mg/L PBTK NA 50% Human Human +DTXSID9021184 Css NA 1.182 mg/L PBTK NA 95% Human Human DTXSID9021184 Clint 5.841 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID9021184 Fup 0.25 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9021184 Vd NA 0.812 L/kg 1compartment NA NA Rat Human DTXSID9021184 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9021184 TK.Half.Life NA 1.369 hours 1compartment NA NA Rat Human -DTXSID9021184 Css NA 0.1124 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021184 Css NA 0.5759 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021184 Css NA 0.1067 mg/L PBTK NA 50% Rat Human -DTXSID9021184 Css NA 0.4132 mg/L PBTK NA 95% Rat Human -DTXSID9021188 Clint NA 2.668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9021184 Css NA 0.02054 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021184 Css NA 0.08488 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021184 Css NA 0.02126 mg/L PBTK NA 50% Rat Human +DTXSID9021184 Css NA 0.08785 mg/L PBTK NA 95% Rat Human +DTXSID9021188 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9021188 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9021188 Vd NA 0.5233 L/kg 1compartment NA NA Human Human DTXSID9021188 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021188 TK.Half.Life NA 5.078 hours 1compartment NA NA Human Human -DTXSID9021188 Css NA 1.318 mg/L 3compartmentss NA 50% Human Human -DTXSID9021188 Css NA 8.288 mg/L 3compartmentss NA 95% Human Human -DTXSID9021188 Css NA 0.908 mg/L PBTK NA 50% Human Human -DTXSID9021188 Css NA 5.255 mg/L PBTK NA 95% Human Human -DTXSID9021188 Clint NA 2.668 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9021188 TK.Half.Life NA 2.638 hours 1compartment NA NA Human Human +DTXSID9021188 Css NA 0.6208 mg/L 3compartmentss NA 50% Human Human +DTXSID9021188 Css NA 4.601 mg/L 3compartmentss NA 95% Human Human +DTXSID9021188 Css NA 0.4305 mg/L PBTK NA 50% Human Human +DTXSID9021188 Css NA 2.858 mg/L PBTK NA 95% Human Human +DTXSID9021188 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9021188 Fup 0.13 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9021188 Vd NA 0.5113 L/kg 1compartment NA NA Rat Human DTXSID9021188 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021188 TK.Half.Life NA 2.837 hours 1compartment NA NA Rat Human -DTXSID9021188 Css NA 0.6264 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021188 Css NA 3.078 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021188 Css NA 0.41 mg/L PBTK NA 50% Rat Human -DTXSID9021188 Css NA 1.766 mg/L PBTK NA 95% Rat Human -DTXSID9021215 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021215 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021215 Vd NA 0.836 L/kg 1compartment NA NA Human Human +DTXSID9021188 TK.Half.Life NA 1.56 hours 1compartment NA NA Rat Human +DTXSID9021188 Css NA 0.07554 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021188 Css NA 0.4197 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021188 Css NA 0.05109 mg/L PBTK NA 50% Rat Human +DTXSID9021188 Css NA 0.2542 mg/L PBTK NA 95% Rat Human +DTXSID9021215 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021215 Fup 0.821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021215 Vd NA 0.7413 L/kg 1compartment NA NA Human Human DTXSID9021215 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021215 TK.Half.Life NA 3.006 hours 1compartment NA NA Human Human -DTXSID9021215 Css NA 0.4354 mg/L 3compartmentss NA 50% Human Human -DTXSID9021215 Css NA 3.001 mg/L 3compartmentss NA 95% Human Human -DTXSID9021215 Css NA 0.3714 mg/L PBTK NA 50% Human Human -DTXSID9021215 Css NA 2.007 mg/L PBTK NA 95% Human Human -DTXSID9021215 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021215 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021215 Vd NA 0.866 L/kg 1compartment NA NA Rat Human +DTXSID9021215 TK.Half.Life NA 5.849 hours 1compartment NA NA Human Human +DTXSID9021215 Css NA 0.9435 mg/L 3compartmentss NA 50% Human Human +DTXSID9021215 Css NA 5.717 mg/L 3compartmentss NA 95% Human Human +DTXSID9021215 Css NA 0.7794 mg/L PBTK NA 50% Human Human +DTXSID9021215 Css NA 3.711 mg/L PBTK NA 95% Human Human +DTXSID9021215 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021215 Fup 0.821 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021215 Vd NA 0.7669 L/kg 1compartment NA NA Rat Human DTXSID9021215 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021215 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Human -DTXSID9021215 Css NA 0.145 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021215 Css NA 0.9131 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021215 Css NA 0.1224 mg/L PBTK NA 50% Rat Human -DTXSID9021215 Css NA 0.5536 mg/L PBTK NA 95% Rat Human +DTXSID9021215 TK.Half.Life NA 2.06 hours 1compartment NA NA Rat Human +DTXSID9021215 Css NA 0.05619 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021215 Css NA 0.3366 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021215 Css NA 0.04656 mg/L PBTK NA 50% Rat Human +DTXSID9021215 Css NA 0.2086 mg/L PBTK NA 95% Rat Human DTXSID9021217 Clint 2.768 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9021217 Fup 0.1177 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9021217 Vd NA 1.655 L/kg 1compartment NA NA Human Human DTXSID9021217 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID9021217 TK.Half.Life NA 20.3 hours 1compartment NA NA Human Human -DTXSID9021217 Css NA 1.682 mg/L 3compartmentss NA 50% Human Human -DTXSID9021217 Css NA 9.8 mg/L 3compartmentss NA 95% Human Human -DTXSID9021217 Css NA 1.17 mg/L PBTK NA 50% Human Human -DTXSID9021217 Css NA 6.132 mg/L PBTK NA 95% Human Human +DTXSID9021217 Css NA 1.651 mg/L 3compartmentss NA 50% Human Human +DTXSID9021217 Css NA 9.178 mg/L 3compartmentss NA 95% Human Human +DTXSID9021217 Css NA 1.138 mg/L PBTK NA 50% Human Human +DTXSID9021217 Css NA 5.767 mg/L PBTK NA 95% Human Human DTXSID9021217 Clint 2.768 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9021217 Fup 0.1177 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9021217 Vd NA 1.335 L/kg 1compartment NA NA Rat Human DTXSID9021217 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID9021217 TK.Half.Life NA 7.796 hours 1compartment NA NA Rat Human -DTXSID9021217 Css NA 0.8169 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021217 Css NA 3.517 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021217 Css NA 0.5354 mg/L PBTK NA 50% Rat Human -DTXSID9021217 Css NA 2.062 mg/L PBTK NA 95% Rat Human -DTXSID9021219 Clint NA 8.978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021219 Fup NA 0.0358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021219 Vd NA 0.2443 L/kg 1compartment NA NA Human Human +DTXSID9021217 Css NA 0.1839 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021217 Css NA 0.8029 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021217 Css NA 0.1251 mg/L PBTK NA 50% Rat Human +DTXSID9021217 Css NA 0.4866 mg/L PBTK NA 95% Rat Human +DTXSID9021219 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021219 Fup 0.0198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021219 Vd NA 0.2294 L/kg 1compartment NA NA Human Human DTXSID9021219 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021219 TK.Half.Life NA 2.953 hours 1compartment NA NA Human Human -DTXSID9021219 Css NA 2.092 mg/L 3compartmentss NA 50% Human Human -DTXSID9021219 Css NA 13.58 mg/L 3compartmentss NA 95% Human Human -DTXSID9021219 Css NA 1.246 mg/L PBTK NA 50% Human Human -DTXSID9021219 Css NA 7.959 mg/L PBTK NA 95% Human Human -DTXSID9021219 Clint NA 8.978 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021219 Fup NA 0.0358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021219 Vd NA 0.2277 L/kg 1compartment NA NA Rat Human +DTXSID9021219 TK.Half.Life NA 2.197 hours 1compartment NA NA Human Human +DTXSID9021219 Css NA 1.426 mg/L 3compartmentss NA 50% Human Human +DTXSID9021219 Css NA 14.24 mg/L 3compartmentss NA 95% Human Human +DTXSID9021219 Css NA 0.838 mg/L PBTK NA 50% Human Human +DTXSID9021219 Css NA 8.27 mg/L PBTK NA 95% Human Human +DTXSID9021219 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021219 Fup 0.0198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021219 Vd NA 0.2104 L/kg 1compartment NA NA Rat Human DTXSID9021219 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021219 TK.Half.Life NA 1.758 hours 1compartment NA NA Rat Human -DTXSID9021219 Css NA 1.137 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021219 Css NA 5.456 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021219 Css NA 0.6288 mg/L PBTK NA 50% Rat Human -DTXSID9021219 Css NA 2.971 mg/L PBTK NA 95% Rat Human -DTXSID9021267 Clint NA 33.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021267 Fup NA 0.7959 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021267 Vd NA 1.146 L/kg 1compartment NA NA Human Human +DTXSID9021219 TK.Half.Life NA 1.322 hours 1compartment NA NA Rat Human +DTXSID9021219 Css NA 0.07045 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021219 Css NA 0.7603 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021219 Css NA 0.03944 mg/L PBTK NA 50% Rat Human +DTXSID9021219 Css NA 0.4226 mg/L PBTK NA 95% Rat Human +DTXSID9021267 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021267 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021267 Vd NA 0.7961 L/kg 1compartment NA NA Human Human DTXSID9021267 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021267 TK.Half.Life NA 0.7928 hours 1compartment NA NA Human Human -DTXSID9021267 Css NA 0.01815 mg/L 3compartmentss NA 50% Human Human -DTXSID9021267 Css NA 0.184 mg/L 3compartmentss NA 95% Human Human -DTXSID9021267 Css NA 0.0156 mg/L PBTK NA 50% Human Human -DTXSID9021267 Css NA 0.1311 mg/L PBTK NA 95% Human Human -DTXSID9021267 Clint NA 33.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021267 Fup NA 0.7959 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021267 Vd NA 1.073 L/kg 1compartment NA NA Rat Human +DTXSID9021267 TK.Half.Life NA 0.8616 hours 1compartment NA NA Human Human +DTXSID9021267 Css NA 0.04536 mg/L 3compartmentss NA 50% Human Human +DTXSID9021267 Css NA 0.3786 mg/L 3compartmentss NA 95% Human Human +DTXSID9021267 Css NA 0.03456 mg/L PBTK NA 50% Human Human +DTXSID9021267 Css NA 0.2623 mg/L PBTK NA 95% Human Human +DTXSID9021267 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021267 Fup 0.425 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021267 Vd NA 0.7408 L/kg 1compartment NA NA Rat Human DTXSID9021267 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021267 TK.Half.Life NA 0.3471 hours 1compartment NA NA Rat Human -DTXSID9021267 Css NA 0.009141 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021267 Css NA 0.0882 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021267 Css NA 0.007817 mg/L PBTK NA 50% Rat Human -DTXSID9021267 Css NA 0.06127 mg/L PBTK NA 95% Rat Human +DTXSID9021267 TK.Half.Life NA 0.4085 hours 1compartment NA NA Rat Human +DTXSID9021267 Css NA 0.005656 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021267 Css NA 0.03689 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021267 Css NA 0.004329 mg/L PBTK NA 50% Rat Human +DTXSID9021267 Css NA 0.02493 mg/L PBTK NA 95% Rat Human DTXSID9021340 Clint NA 0.178 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021340 Fup NA 0.9073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021340 Vd NA 1.075 L/kg 1compartment NA NA Human Human DTXSID9021340 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9021340 TK.Half.Life NA 5.97 hours 1compartment NA NA Human Human -DTXSID9021340 Css NA 0.6637 mg/L 3compartmentss NA 50% Human Human -DTXSID9021340 Css NA 4.042 mg/L 3compartmentss NA 95% Human Human -DTXSID9021340 Css NA 0.5798 mg/L PBTK NA 50% Human Human -DTXSID9021340 Css NA 2.63 mg/L PBTK NA 95% Human Human +DTXSID9021340 Css NA 0.5604 mg/L 3compartmentss NA 50% Human Human +DTXSID9021340 Css NA 3.434 mg/L 3compartmentss NA 95% Human Human +DTXSID9021340 Css NA 0.4916 mg/L PBTK NA 50% Human Human +DTXSID9021340 Css NA 2.279 mg/L PBTK NA 95% Human Human DTXSID9021340 Clint NA 0.178 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021340 Fup NA 0.9073 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021340 Vd NA 1.094 L/kg 1compartment NA NA Rat Human DTXSID9021340 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9021340 TK.Half.Life NA 2.331 hours 1compartment NA NA Rat Human -DTXSID9021340 Css NA 0.1912 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021340 Css NA 1.138 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021340 Css NA 0.1639 mg/L PBTK NA 50% Rat Human -DTXSID9021340 Css NA 0.6989 mg/L PBTK NA 95% Rat Human -DTXSID9021342 Clint NA 20.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021342 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021342 Vd NA 1.82 L/kg 1compartment NA NA Human Human -DTXSID9021342 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID9021342 TK.Half.Life NA 67.49 hours 1compartment NA NA Human Human -DTXSID9021342 Css NA 6.205 mg/L 3compartmentss NA 50% Human Human -DTXSID9021342 Css NA 46.75 mg/L 3compartmentss NA 95% Human Human -DTXSID9021342 Css NA 3.878 mg/L PBTK NA 50% Human Human -DTXSID9021342 Css NA 28.55 mg/L PBTK NA 95% Human Human -DTXSID9021342 Clint NA 20.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021342 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021342 Vd NA 1.341 L/kg 1compartment NA NA Rat Human -DTXSID9021342 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID9021342 TK.Half.Life NA 24.01 hours 1compartment NA NA Rat Human -DTXSID9021342 Css NA 3.532 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021342 Css NA 20.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021342 Css NA 2.082 mg/L PBTK NA 50% Rat Human -DTXSID9021342 Css NA 11.94 mg/L PBTK NA 95% Rat Human -DTXSID9021344 Clint NA 25.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021344 Fup NA 0.1286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021344 Vd NA 1.03 L/kg 1compartment NA NA Human Human +DTXSID9021340 Css NA 0.01215 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021340 Css NA 0.0888 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021340 Css NA 0.0103 mg/L PBTK NA 50% Rat Human +DTXSID9021340 Css NA 0.05997 mg/L PBTK NA 95% Rat Human +DTXSID9021342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021342 Fup 0.00515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021342 Vd NA 2.373 L/kg 1compartment NA NA Human Human +DTXSID9021342 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID9021342 TK.Half.Life NA 53.82 hours 1compartment NA NA Human Human +DTXSID9021342 Css NA 3.36 mg/L 3compartmentss NA 50% Human Human +DTXSID9021342 Css NA 26.87 mg/L 3compartmentss NA 95% Human Human +DTXSID9021342 Css NA 2.201 mg/L PBTK NA 50% Human Human +DTXSID9021342 Css NA 16.8 mg/L PBTK NA 95% Human Human +DTXSID9021342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021342 Fup 0.00515 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021342 Vd NA 1.764 L/kg 1compartment NA NA Rat Human +DTXSID9021342 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID9021342 TK.Half.Life NA 14.78 hours 1compartment NA NA Rat Human +DTXSID9021342 Css NA 0.4454 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021342 Css NA 2.889 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021342 Css NA 0.285 mg/L PBTK NA 50% Rat Human +DTXSID9021342 Css NA 1.77 mg/L PBTK NA 95% Rat Human +DTXSID9021344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021344 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021344 Vd NA 0.9844 L/kg 1compartment NA NA Human Human DTXSID9021344 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021344 TK.Half.Life NA 2.081 hours 1compartment NA NA Human Human -DTXSID9021344 Css NA 0.1907 mg/L 3compartmentss NA 50% Human Human -DTXSID9021344 Css NA 1.518 mg/L 3compartmentss NA 95% Human Human -DTXSID9021344 Css NA 0.1264 mg/L PBTK NA 50% Human Human -DTXSID9021344 Css NA 0.9499 mg/L PBTK NA 95% Human Human -DTXSID9021344 Clint NA 25.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021344 Fup NA 0.1286 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021344 Vd NA 0.8212 L/kg 1compartment NA NA Rat Human +DTXSID9021344 TK.Half.Life NA 2.306 hours 1compartment NA NA Human Human +DTXSID9021344 Css NA 0.2351 mg/L 3compartmentss NA 50% Human Human +DTXSID9021344 Css NA 1.89 mg/L 3compartmentss NA 95% Human Human +DTXSID9021344 Css NA 0.153 mg/L PBTK NA 50% Human Human +DTXSID9021344 Css NA 1.173 mg/L PBTK NA 95% Human Human +DTXSID9021344 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021344 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021344 Vd NA 0.7846 L/kg 1compartment NA NA Rat Human DTXSID9021344 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021344 TK.Half.Life NA 0.8969 hours 1compartment NA NA Rat Human -DTXSID9021344 Css NA 0.1055 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021344 Css NA 0.657 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021344 Css NA 0.06593 mg/L PBTK NA 50% Rat Human -DTXSID9021344 Css NA 0.3861 mg/L PBTK NA 95% Rat Human +DTXSID9021344 TK.Half.Life NA 1.015 hours 1compartment NA NA Rat Human +DTXSID9021344 Css NA 0.03021 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021344 Css NA 0.19 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021344 Css NA 0.01935 mg/L PBTK NA 50% Rat Human +DTXSID9021344 Css NA 0.1146 mg/L PBTK NA 95% Rat Human DTXSID9021346 Clint NA 4.257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021346 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021346 Vd NA 0.6972 L/kg 1compartment NA NA Human Human +DTXSID9021346 Vd NA 0.6989 L/kg 1compartment NA NA Human Human DTXSID9021346 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021346 TK.Half.Life NA 0.8518 hours 1compartment NA NA Human Human -DTXSID9021346 Css NA 0.1066 mg/L 3compartmentss NA 50% Human Human -DTXSID9021346 Css NA 0.9309 mg/L 3compartmentss NA 95% Human Human -DTXSID9021346 Css NA 0.08623 mg/L PBTK NA 50% Human Human -DTXSID9021346 Css NA 0.646 mg/L PBTK NA 95% Human Human +DTXSID9021346 TK.Half.Life NA 0.8547 hours 1compartment NA NA Human Human +DTXSID9021346 Css NA 0.08518 mg/L 3compartmentss NA 50% Human Human +DTXSID9021346 Css NA 0.8045 mg/L 3compartmentss NA 95% Human Human +DTXSID9021346 Css NA 0.06912 mg/L PBTK NA 50% Human Human +DTXSID9021346 Css NA 0.5568 mg/L PBTK NA 95% Human Human DTXSID9021346 Clint NA 4.257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021346 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021346 Vd NA 0.7477 L/kg 1compartment NA NA Rat Human +DTXSID9021346 Vd NA 0.7492 L/kg 1compartment NA NA Rat Human DTXSID9021346 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021346 TK.Half.Life NA 0.4751 hours 1compartment NA NA Rat Human -DTXSID9021346 Css NA 0.04889 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021346 Css NA 0.3376 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021346 Css NA 0.03942 mg/L PBTK NA 50% Rat Human -DTXSID9021346 Css NA 0.2149 mg/L PBTK NA 95% Rat Human +DTXSID9021346 TK.Half.Life NA 0.4764 hours 1compartment NA NA Rat Human +DTXSID9021346 Css NA 0.002767 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021346 Css NA 0.02833 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021346 Css NA 0.00224 mg/L PBTK NA 50% Rat Human +DTXSID9021346 Css NA 0.01976 mg/L PBTK NA 95% Rat Human DTXSID9021348 Clint NA 0.07948 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021348 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021348 Vd NA 0.786 L/kg 1compartment NA NA Human Human DTXSID9021348 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9021348 TK.Half.Life NA 4.504 hours 1compartment NA NA Human Human -DTXSID9021348 Css NA 0.7178 mg/L 3compartmentss NA 50% Human Human -DTXSID9021348 Css NA 4.717 mg/L 3compartmentss NA 95% Human Human -DTXSID9021348 Css NA 0.6042 mg/L PBTK NA 50% Human Human -DTXSID9021348 Css NA 3.129 mg/L PBTK NA 95% Human Human +DTXSID9021348 Css NA 0.6047 mg/L 3compartmentss NA 50% Human Human +DTXSID9021348 Css NA 3.842 mg/L 3compartmentss NA 95% Human Human +DTXSID9021348 Css NA 0.5127 mg/L PBTK NA 50% Human Human +DTXSID9021348 Css NA 2.525 mg/L PBTK NA 95% Human Human DTXSID9021348 Clint NA 0.07948 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021348 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021348 Vd NA 0.823 L/kg 1compartment NA NA Rat Human DTXSID9021348 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9021348 TK.Half.Life NA 1.706 hours 1compartment NA NA Rat Human -DTXSID9021348 Css NA 0.1949 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021348 Css NA 1.227 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021348 Css NA 0.1615 mg/L PBTK NA 50% Rat Human -DTXSID9021348 Css NA 0.7415 mg/L PBTK NA 95% Rat Human +DTXSID9021348 Css NA 0.0118 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021348 Css NA 0.09611 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021348 Css NA 0.009672 mg/L PBTK NA 50% Rat Human +DTXSID9021348 Css NA 0.06383 mg/L PBTK NA 95% Rat Human DTXSID9021392 Clint NA 0.2974 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021392 Fup NA 0.9182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021392 Vd NA 1.778 L/kg 1compartment NA NA Human Human DTXSID9021392 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9021392 TK.Half.Life NA 8.488 hours 1compartment NA NA Human Human -DTXSID9021392 Css NA 0.486 mg/L 3compartmentss NA 50% Human Human -DTXSID9021392 Css NA 2.034 mg/L 3compartmentss NA 95% Human Human -DTXSID9021392 Css NA 0.4798 mg/L PBTK NA 50% Human Human -DTXSID9021392 Css NA 1.553 mg/L PBTK NA 95% Human Human +DTXSID9021392 Css NA 0.413 mg/L 3compartmentss NA 50% Human Human +DTXSID9021392 Css NA 1.814 mg/L 3compartmentss NA 95% Human Human +DTXSID9021392 Css NA 0.4094 mg/L PBTK NA 50% Human Human +DTXSID9021392 Css NA 1.375 mg/L PBTK NA 95% Human Human DTXSID9021392 Clint NA 0.2974 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021392 Fup NA 0.9182 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021392 Vd NA 1.817 L/kg 1compartment NA NA Rat Human DTXSID9021392 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9021392 TK.Half.Life NA 3.535 hours 1compartment NA NA Rat Human -DTXSID9021392 Css NA 0.1491 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021392 Css NA 0.5607 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021392 Css NA 0.1473 mg/L PBTK NA 50% Rat Human -DTXSID9021392 Css NA 0.3962 mg/L PBTK NA 95% Rat Human -DTXSID9021396 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9021392 Css NA 0.009058 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021392 Css NA 0.05176 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021392 Css NA 0.008755 mg/L PBTK NA 50% Rat Human +DTXSID9021392 Css NA 0.04258 mg/L PBTK NA 95% Rat Human +DTXSID9021396 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9021396 Fup 0.89 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID9021396 Vd NA 1.182 L/kg 1compartment NA NA Human Human +DTXSID9021396 Vd NA 1.107 L/kg 1compartment NA NA Human Human DTXSID9021396 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021396 TK.Half.Life NA 8.68 hours 1compartment NA NA Human Human -DTXSID9021396 Css NA 1.095 mg/L 3compartmentss NA 50% Human Human -DTXSID9021396 Css NA 5.548 mg/L 3compartmentss NA 95% Human Human -DTXSID9021396 Css NA 0.7715 mg/L PBTK NA 50% Human Human -DTXSID9021396 Css NA 3.431 mg/L PBTK NA 95% Human Human -DTXSID9021396 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9021396 TK.Half.Life NA 8.096 hours 1compartment NA NA Human Human +DTXSID9021396 Css NA 1.026 mg/L 3compartmentss NA 50% Human Human +DTXSID9021396 Css NA 4.515 mg/L 3compartmentss NA 95% Human Human +DTXSID9021396 Css NA 0.7456 mg/L PBTK NA 50% Human Human +DTXSID9021396 Css NA 3.279 mg/L PBTK NA 95% Human Human +DTXSID9021396 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9021396 Fup 0.89 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID9021396 Vd NA 1.186 L/kg 1compartment NA NA Rat Human +DTXSID9021396 Vd NA 1.118 L/kg 1compartment NA NA Rat Human DTXSID9021396 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021396 TK.Half.Life NA 2.946 hours 1compartment NA NA Rat Human -DTXSID9021396 Css NA 0.2834 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021396 Css NA 1.427 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021396 Css NA 0.1914 mg/L PBTK NA 50% Rat Human -DTXSID9021396 Css NA 0.8156 mg/L PBTK NA 95% Rat Human -DTXSID9021398 Clint NA 2.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021398 Fup NA 0.2908 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021398 Vd NA 1.673 L/kg 1compartment NA NA Human Human +DTXSID9021396 TK.Half.Life NA 2.774 hours 1compartment NA NA Rat Human +DTXSID9021396 Css NA 0.05945 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021396 Css NA 0.2559 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021396 Css NA 0.04472 mg/L PBTK NA 50% Rat Human +DTXSID9021396 Css NA 0.1925 mg/L PBTK NA 95% Rat Human +DTXSID9021398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021398 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021398 Vd NA 1.505 L/kg 1compartment NA NA Human Human DTXSID9021398 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021398 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human -DTXSID9021398 Css NA 0.7368 mg/L 3compartmentss NA 50% Human Human -DTXSID9021398 Css NA 3.372 mg/L 3compartmentss NA 95% Human Human -DTXSID9021398 Css NA 0.562 mg/L PBTK NA 50% Human Human -DTXSID9021398 Css NA 2.325 mg/L PBTK NA 95% Human Human -DTXSID9021398 Clint NA 2.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021398 Fup NA 0.2908 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021398 Vd NA 1.336 L/kg 1compartment NA NA Rat Human +DTXSID9021398 TK.Half.Life NA 2.438 hours 1compartment NA NA Human Human +DTXSID9021398 Css NA 0.1045 mg/L 3compartmentss NA 50% Human Human +DTXSID9021398 Css NA 0.7147 mg/L 3compartmentss NA 95% Human Human +DTXSID9021398 Css NA 0.07634 mg/L PBTK NA 50% Human Human +DTXSID9021398 Css NA 0.4931 mg/L PBTK NA 95% Human Human +DTXSID9021398 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021398 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021398 Vd NA 1.199 L/kg 1compartment NA NA Rat Human DTXSID9021398 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021398 TK.Half.Life NA 4.104 hours 1compartment NA NA Rat Human -DTXSID9021398 Css NA 0.3351 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021398 Css NA 1.191 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021398 Css NA 0.2461 mg/L PBTK NA 50% Rat Human -DTXSID9021398 Css NA 0.7493 mg/L PBTK NA 95% Rat Human -DTXSID9021425 Clint NA 22.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021425 Fup NA 0.3177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021425 Vd NA 1.965 L/kg 1compartment NA NA Human Human +DTXSID9021398 TK.Half.Life NA 0.9602 hours 1compartment NA NA Rat Human +DTXSID9021398 Css NA 0.01296 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021398 Css NA 0.0706 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021398 Css NA 0.009474 mg/L PBTK NA 50% Rat Human +DTXSID9021398 Css NA 0.04747 mg/L PBTK NA 95% Rat Human +DTXSID9021425 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021425 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021425 Vd NA 2.131 L/kg 1compartment NA NA Human Human DTXSID9021425 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021425 TK.Half.Life NA 2.157 hours 1compartment NA NA Human Human -DTXSID9021425 Css NA 0.05257 mg/L 3compartmentss NA 50% Human Human -DTXSID9021425 Css NA 0.4148 mg/L 3compartmentss NA 95% Human Human -DTXSID9021425 Css NA 0.0471 mg/L PBTK NA 50% Human Human -DTXSID9021425 Css NA 0.3209 mg/L PBTK NA 95% Human Human -DTXSID9021425 Clint NA 22.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021425 Fup NA 0.3177 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021425 Vd NA 1.952 L/kg 1compartment NA NA Rat Human +DTXSID9021425 TK.Half.Life NA 4.384 hours 1compartment NA NA Human Human +DTXSID9021425 Css NA 0.1418 mg/L 3compartmentss NA 50% Human Human +DTXSID9021425 Css NA 1.012 mg/L 3compartmentss NA 95% Human Human +DTXSID9021425 Css NA 0.1342 mg/L PBTK NA 50% Human Human +DTXSID9021425 Css NA 0.7839 mg/L PBTK NA 95% Human Human +DTXSID9021425 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021425 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021425 Vd NA 2.122 L/kg 1compartment NA NA Rat Human DTXSID9021425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021425 TK.Half.Life NA 1.149 hours 1compartment NA NA Rat Human -DTXSID9021425 Css NA 0.02748 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021425 Css NA 0.17 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021425 Css NA 0.02398 mg/L PBTK NA 50% Rat Human -DTXSID9021425 Css NA 0.1255 mg/L PBTK NA 95% Rat Human -DTXSID9021427 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021427 Fup NA 0.8886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021427 Vd NA 0.847 L/kg 1compartment NA NA Human Human +DTXSID9021425 TK.Half.Life NA 2.478 hours 1compartment NA NA Rat Human +DTXSID9021425 Css NA 0.01635 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021425 Css NA 0.09062 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021425 Css NA 0.01561 mg/L PBTK NA 50% Rat Human +DTXSID9021425 Css NA 0.06625 mg/L PBTK NA 95% Rat Human +DTXSID9021427 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021427 Fup 0.724 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021427 Vd NA 0.7475 L/kg 1compartment NA NA Human Human DTXSID9021427 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021427 TK.Half.Life NA 6.194 hours 1compartment NA NA Human Human -DTXSID9021427 Css NA 0.9113 mg/L 3compartmentss NA 50% Human Human -DTXSID9021427 Css NA 5.312 mg/L 3compartmentss NA 95% Human Human -DTXSID9021427 Css NA 0.7741 mg/L PBTK NA 50% Human Human -DTXSID9021427 Css NA 3.452 mg/L PBTK NA 95% Human Human -DTXSID9021427 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021427 Fup NA 0.8886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021427 Vd NA 0.8632 L/kg 1compartment NA NA Rat Human +DTXSID9021427 TK.Half.Life NA 6.704 hours 1compartment NA NA Human Human +DTXSID9021427 Css NA 0.8948 mg/L 3compartmentss NA 50% Human Human +DTXSID9021427 Css NA 6.07 mg/L 3compartmentss NA 95% Human Human +DTXSID9021427 Css NA 0.7427 mg/L PBTK NA 50% Human Human +DTXSID9021427 Css NA 3.875 mg/L PBTK NA 95% Human Human +DTXSID9021427 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021427 Fup 0.724 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021427 Vd NA 0.7612 L/kg 1compartment NA NA Rat Human DTXSID9021427 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021427 TK.Half.Life NA 2.145 hours 1compartment NA NA Rat Human -DTXSID9021427 Css NA 0.2331 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021427 Css NA 1.337 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021427 Css NA 0.1924 mg/L PBTK NA 50% Rat Human -DTXSID9021427 Css NA 0.8127 mg/L PBTK NA 95% Rat Human -DTXSID9021477 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021477 Fup NA 0.3474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021477 Vd NA 3.285 L/kg 1compartment NA NA Human Human -DTXSID9021477 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID9021477 TK.Half.Life NA 155200 hours 1compartment NA NA Human Human -DTXSID9021477 Css NA 5138 mg/L 3compartmentss NA 50% Human Human -DTXSID9021477 Css NA 11530 mg/L 3compartmentss NA 95% Human Human -DTXSID9021477 Css NA 3625 mg/L PBTK NA 50% Human Human -DTXSID9021477 Css NA 7848 mg/L PBTK NA 95% Human Human -DTXSID9021477 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021477 Fup NA 0.3474 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021477 Vd NA 2.466 L/kg 1compartment NA NA Rat Human -DTXSID9021477 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID9021477 TK.Half.Life NA 9476 hours 1compartment NA NA Rat Human -DTXSID9021477 Css NA 1425 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021477 Css NA 2072 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021477 Css NA 964.6 mg/L PBTK NA 50% Rat Human -DTXSID9021477 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID9021479 Clint NA 11.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021479 Fup NA 0.0928 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021479 Vd NA 0.8841 L/kg 1compartment NA NA Human Human +DTXSID9021427 TK.Half.Life NA 2.321 hours 1compartment NA NA Rat Human +DTXSID9021427 Css NA 0.01706 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021427 Css NA 0.147 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021427 Css NA 0.01348 mg/L PBTK NA 50% Rat Human +DTXSID9021427 Css NA 0.09441 mg/L PBTK NA 95% Rat Human +DTXSID9021479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021479 Fup 0.0695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021479 Vd NA 1.01 L/kg 1compartment NA NA Human Human DTXSID9021479 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021479 TK.Half.Life NA 3.717 hours 1compartment NA NA Human Human -DTXSID9021479 Css NA 0.561 mg/L 3compartmentss NA 50% Human Human -DTXSID9021479 Css NA 4.112 mg/L 3compartmentss NA 95% Human Human -DTXSID9021479 Css NA 0.3592 mg/L PBTK NA 50% Human Human -DTXSID9021479 Css NA 2.539 mg/L PBTK NA 95% Human Human -DTXSID9021479 Clint NA 11.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021479 Fup NA 0.0928 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021479 Vd NA 0.7017 L/kg 1compartment NA NA Rat Human +DTXSID9021479 TK.Half.Life NA 3.443 hours 1compartment NA NA Human Human +DTXSID9021479 Css NA 0.431 mg/L 3compartmentss NA 50% Human Human +DTXSID9021479 Css NA 3.345 mg/L 3compartmentss NA 95% Human Human +DTXSID9021479 Css NA 0.2732 mg/L PBTK NA 50% Human Human +DTXSID9021479 Css NA 2.031 mg/L PBTK NA 95% Human Human +DTXSID9021479 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021479 Fup 0.0695 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021479 Vd NA 0.7809 L/kg 1compartment NA NA Rat Human DTXSID9021479 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021479 TK.Half.Life NA 1.709 hours 1compartment NA NA Rat Human -DTXSID9021479 Css NA 0.3067 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021479 Css NA 1.779 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021479 Css NA 0.1846 mg/L PBTK NA 50% Rat Human -DTXSID9021479 Css NA 1.006 mg/L PBTK NA 95% Rat Human -DTXSID9021554 Clint NA 1.164 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021554 Fup NA 0.0782 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021554 Vd NA 0.6273 L/kg 1compartment NA NA Human Human -DTXSID9021554 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9021554 TK.Half.Life NA 17.97 hours 1compartment NA NA Human Human -DTXSID9021554 Css NA 4.289 mg/L 3compartmentss NA 50% Human Human -DTXSID9021554 Css NA 23.15 mg/L 3compartmentss NA 95% Human Human -DTXSID9021554 Css NA 2.835 mg/L PBTK NA 50% Human Human -DTXSID9021554 Css NA 14.03 mg/L PBTK NA 95% Human Human -DTXSID9021554 Clint NA 1.164 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021554 Fup NA 0.0782 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021554 Vd NA 0.5389 L/kg 1compartment NA NA Rat Human +DTXSID9021479 TK.Half.Life NA 1.505 hours 1compartment NA NA Rat Human +DTXSID9021479 Css NA 0.05554 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021479 Css NA 0.3357 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021479 Css NA 0.03416 mg/L PBTK NA 50% Rat Human +DTXSID9021479 Css NA 0.2011 mg/L PBTK NA 95% Rat Human +DTXSID9021554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021554 Fup 0.0988 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021554 Vd NA 0.7101 L/kg 1compartment NA NA Human Human +DTXSID9021554 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9021554 TK.Half.Life NA 1.794 hours 1compartment NA NA Human Human +DTXSID9021554 Css NA 0.2631 mg/L 3compartmentss NA 50% Human Human +DTXSID9021554 Css NA 2.253 mg/L 3compartmentss NA 95% Human Human +DTXSID9021554 Css NA 0.1788 mg/L PBTK NA 50% Human Human +DTXSID9021554 Css NA 1.434 mg/L PBTK NA 95% Human Human +DTXSID9021554 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021554 Fup 0.0988 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021554 Vd NA 0.6105 L/kg 1compartment NA NA Rat Human DTXSID9021554 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021554 TK.Half.Life NA 7.753 hours 1compartment NA NA Rat Human -DTXSID9021554 Css NA 1.845 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021554 Css NA 8.113 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021554 Css NA 1.15 mg/L PBTK NA 50% Rat Human -DTXSID9021554 Css NA 4.54 mg/L PBTK NA 95% Rat Human -DTXSID9021633 Clint NA 0.02043 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021633 Fup NA 0.358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021633 Vd NA 0.4637 L/kg 1compartment NA NA Human Human +DTXSID9021554 TK.Half.Life NA 0.9018 hours 1compartment NA NA Rat Human +DTXSID9021554 Css NA 0.0342 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021554 Css NA 0.2209 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021554 Css NA 0.02274 mg/L PBTK NA 50% Rat Human +DTXSID9021554 Css NA 0.1345 mg/L PBTK NA 95% Rat Human +DTXSID9021633 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021633 Fup 0.542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021633 Vd NA 0.5805 L/kg 1compartment NA NA Human Human DTXSID9021633 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021633 TK.Half.Life NA 8.113 hours 1compartment NA NA Human Human -DTXSID9021633 Css NA 1.976 mg/L 3compartmentss NA 50% Human Human -DTXSID9021633 Css NA 8.495 mg/L 3compartmentss NA 95% Human Human -DTXSID9021633 Css NA 1.43 mg/L PBTK NA 50% Human Human -DTXSID9021633 Css NA 5.336 mg/L PBTK NA 95% Human Human -DTXSID9021633 Clint NA 0.02043 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021633 Fup NA 0.358 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021633 Vd NA 0.4615 L/kg 1compartment NA NA Rat Human +DTXSID9021633 TK.Half.Life NA 6.94 hours 1compartment NA NA Human Human +DTXSID9021633 Css NA 1.132 mg/L 3compartmentss NA 50% Human Human +DTXSID9021633 Css NA 7.16 mg/L 3compartmentss NA 95% Human Human +DTXSID9021633 Css NA 0.8978 mg/L PBTK NA 50% Human Human +DTXSID9021633 Css NA 4.488 mg/L PBTK NA 95% Human Human +DTXSID9021633 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021633 Fup 0.542 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021633 Vd NA 0.58 L/kg 1compartment NA NA Rat Human DTXSID9021633 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021633 TK.Half.Life NA 2.796 hours 1compartment NA NA Rat Human -DTXSID9021633 Css NA 0.5508 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021633 Css NA 2.081 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021633 Css NA 0.38 mg/L PBTK NA 50% Rat Human -DTXSID9021633 Css NA 1.221 mg/L PBTK NA 95% Rat Human -DTXSID9021637 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021637 Fup NA 0.5203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021637 Vd NA 0.5048 L/kg 1compartment NA NA Human Human -DTXSID9021637 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021637 TK.Half.Life NA 6.284 hours 1compartment NA NA Human Human -DTXSID9021637 Css NA 1.447 mg/L 3compartmentss NA 50% Human Human -DTXSID9021637 Css NA 7.812 mg/L 3compartmentss NA 95% Human Human -DTXSID9021637 Css NA 1.088 mg/L PBTK NA 50% Human Human -DTXSID9021637 Css NA 4.847 mg/L PBTK NA 95% Human Human -DTXSID9021637 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021637 Fup NA 0.5203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021637 Vd NA 0.5069 L/kg 1compartment NA NA Rat Human -DTXSID9021637 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021637 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human -DTXSID9021637 Css NA 0.3868 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021637 Css NA 1.889 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021637 Css NA 0.2778 mg/L PBTK NA 50% Rat Human -DTXSID9021637 Css NA 1.104 mg/L PBTK NA 95% Rat Human -DTXSID9021683 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021683 Fup NA 0.1043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021683 Vd NA 0.5516 L/kg 1compartment NA NA Human Human -DTXSID9021683 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID9021683 TK.Half.Life NA 34.45 hours 1compartment NA NA Human Human -DTXSID9021683 Css NA 8.726 mg/L 3compartmentss NA 50% Human Human -DTXSID9021683 Css NA 42.39 mg/L 3compartmentss NA 95% Human Human -DTXSID9021683 Css NA 6.008 mg/L PBTK NA 50% Human Human -DTXSID9021683 Css NA 25.85 mg/L PBTK NA 95% Human Human -DTXSID9021683 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021683 Fup NA 0.1043 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021683 Vd NA 0.5287 L/kg 1compartment NA NA Rat Human -DTXSID9021683 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9021683 TK.Half.Life NA 11.2 hours 1compartment NA NA Rat Human -DTXSID9021683 Css NA 2.432 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021683 Css NA 10.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021683 Css NA 1.586 mg/L PBTK NA 50% Rat Human -DTXSID9021683 Css NA 5.851 mg/L PBTK NA 95% Rat Human -DTXSID9021685 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021685 Fup NA 0.7186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021685 Vd NA 2.13 L/kg 1compartment NA NA Human Human -DTXSID9021685 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9021685 TK.Half.Life NA 30.45 hours 1compartment NA NA Human Human -DTXSID9021685 Css NA 1.413 mg/L 3compartmentss NA 50% Human Human -DTXSID9021685 Css NA 7.653 mg/L 3compartmentss NA 95% Human Human -DTXSID9021685 Css NA 1.266 mg/L PBTK NA 50% Human Human -DTXSID9021685 Css NA 5.174 mg/L PBTK NA 95% Human Human -DTXSID9021685 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021685 Fup NA 0.7186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021685 Vd NA 1.753 L/kg 1compartment NA NA Rat Human +DTXSID9021633 TK.Half.Life NA 2.361 hours 1compartment NA NA Rat Human +DTXSID9021633 Css NA 0.02124 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021633 Css NA 0.1767 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021633 Css NA 0.01632 mg/L PBTK NA 50% Rat Human +DTXSID9021633 Css NA 0.1114 mg/L PBTK NA 95% Rat Human +DTXSID9021683 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021683 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021683 Vd NA 0.5087 L/kg 1compartment NA NA Human Human +DTXSID9021683 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9021683 TK.Half.Life NA 25.59 hours 1compartment NA NA Human Human +DTXSID9021683 Css NA 6.662 mg/L 3compartmentss NA 50% Human Human +DTXSID9021683 Css NA 32.18 mg/L 3compartmentss NA 95% Human Human +DTXSID9021683 Css NA 4.594 mg/L PBTK NA 50% Human Human +DTXSID9021683 Css NA 19.74 mg/L PBTK NA 95% Human Human +DTXSID9021683 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021683 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021683 Vd NA 0.4948 L/kg 1compartment NA NA Rat Human +DTXSID9021683 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9021683 TK.Half.Life NA 8.464 hours 1compartment NA NA Rat Human +DTXSID9021683 Css NA 0.4308 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021683 Css NA 1.776 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021683 Css NA 0.2905 mg/L PBTK NA 50% Rat Human +DTXSID9021683 Css NA 1.049 mg/L PBTK NA 95% Rat Human +DTXSID9021685 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021685 Fup 0.516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021685 Vd NA 0.988 L/kg 1compartment NA NA Human Human +DTXSID9021685 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9021685 TK.Half.Life NA 13 hours 1compartment NA NA Human Human +DTXSID9021685 Css NA 1.359 mg/L 3compartmentss NA 50% Human Human +DTXSID9021685 Css NA 7.416 mg/L 3compartmentss NA 95% Human Human +DTXSID9021685 Css NA 1.109 mg/L PBTK NA 50% Human Human +DTXSID9021685 Css NA 4.815 mg/L PBTK NA 95% Human Human +DTXSID9021685 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021685 Fup 0.516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021685 Vd NA 0.908 L/kg 1compartment NA NA Rat Human DTXSID9021685 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021685 TK.Half.Life NA 6.134 hours 1compartment NA NA Rat Human -DTXSID9021685 Css NA 0.3672 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021685 Css NA 1.94 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021685 Css NA 0.3228 mg/L PBTK NA 50% Rat Human -DTXSID9021685 Css NA 1.222 mg/L PBTK NA 95% Rat Human +DTXSID9021685 TK.Half.Life NA 3.927 hours 1compartment NA NA Rat Human +DTXSID9021685 Css NA 0.08324 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021685 Css NA 0.419 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021685 Css NA 0.06792 mg/L PBTK NA 50% Rat Human +DTXSID9021685 Css NA 0.2621 mg/L PBTK NA 95% Rat Human +DTXSID9021689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021689 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021689 Vd NA 7.351 L/kg 1compartment NA NA Human Human +DTXSID9021689 Days.Css NA 43 Days PBTK NA NA Human Human +DTXSID9021689 TK.Half.Life NA 219.4 hours 1compartment NA NA Human Human +DTXSID9021689 Css NA 1.304 mg/L 3compartmentss NA 50% Human Human +DTXSID9021689 Css NA 8.621 mg/L 3compartmentss NA 95% Human Human +DTXSID9021689 Css NA 1.283 mg/L PBTK NA 50% Human Human +DTXSID9021689 Css NA 8.076 mg/L PBTK NA 95% Human Human +DTXSID9021689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021689 Fup 0.0338 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021689 Vd NA 5.709 L/kg 1compartment NA NA Rat Human +DTXSID9021689 Days.Css NA 25 Days PBTK NA NA Rat Human +DTXSID9021689 TK.Half.Life NA 29.71 hours 1compartment NA NA Rat Human +DTXSID9021689 Css NA 0.0139 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021689 Css NA 0.08342 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021689 Css NA 0.01352 mg/L PBTK NA 50% Rat Human +DTXSID9021689 Css NA 0.08041 mg/L PBTK NA 95% Rat Human DTXSID9021716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9021716 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021716 Vd NA 0.8456 L/kg 1compartment NA NA Human Human -DTXSID9021716 Days.Css NA 267 Days PBTK NA NA Human Human -DTXSID9021716 TK.Half.Life NA 1016 hours 1compartment NA NA Human Human -DTXSID9021716 Css NA 201 mg/L 3compartmentss NA 50% Human Human -DTXSID9021716 Css NA 1150 mg/L 3compartmentss NA 95% Human Human -DTXSID9021716 Css NA 120.4 mg/L PBTK NA 50% Human Human -DTXSID9021716 Css NA 672.7 mg/L PBTK NA 95% Human Human +DTXSID9021716 Fup 0.00605 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021716 Vd NA 0.842 L/kg 1compartment NA NA Human Human +DTXSID9021716 Days.Css NA 269 Days PBTK NA NA Human Human +DTXSID9021716 TK.Half.Life NA 1019 hours 1compartment NA NA Human Human +DTXSID9021716 Css NA 197.2 mg/L 3compartmentss NA 50% Human Human +DTXSID9021716 Css NA 1131 mg/L 3compartmentss NA 95% Human Human +DTXSID9021716 Css NA 117.6 mg/L PBTK NA 50% Human Human +DTXSID9021716 Css NA 660.5 mg/L PBTK NA 95% Human Human DTXSID9021716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9021716 Fup NA 0.0061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021716 Vd NA 0.6225 L/kg 1compartment NA NA Rat Human +DTXSID9021716 Fup 0.00605 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021716 Vd NA 0.62 L/kg 1compartment NA NA Rat Human DTXSID9021716 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9021716 TK.Half.Life NA 21.03 hours 1compartment NA NA Rat Human -DTXSID9021716 Css NA 5.666 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021716 Css NA 40.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021716 Css NA 3.151 mg/L PBTK NA 50% Rat Human -DTXSID9021716 Css NA 22.09 mg/L PBTK NA 95% Rat Human -DTXSID9021718 Clint NA 101.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021718 Fup NA 0.7779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021718 Vd NA 4.505 L/kg 1compartment NA NA Human Human +DTXSID9021716 TK.Half.Life NA 21.12 hours 1compartment NA NA Rat Human +DTXSID9021716 Css NA 1.294 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021716 Css NA 8.869 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021716 Css NA 0.7476 mg/L PBTK NA 50% Rat Human +DTXSID9021716 Css NA 5.011 mg/L PBTK NA 95% Rat Human +DTXSID9021718 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021718 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021718 Vd NA 1.569 L/kg 1compartment NA NA Human Human DTXSID9021718 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021718 TK.Half.Life NA 1.488 hours 1compartment NA NA Human Human -DTXSID9021718 Css NA 0.002982 mg/L 3compartmentss NA 50% Human Human -DTXSID9021718 Css NA 0.04151 mg/L 3compartmentss NA 95% Human Human -DTXSID9021718 Css NA 0.004677 mg/L PBTK NA 50% Human Human -DTXSID9021718 Css NA 0.04092 mg/L PBTK NA 95% Human Human -DTXSID9021718 Clint NA 101.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021718 Fup NA 0.7779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021718 Vd NA 4.5 L/kg 1compartment NA NA Rat Human +DTXSID9021718 TK.Half.Life NA 1.421 hours 1compartment NA NA Human Human +DTXSID9021718 Css NA 0.0338 mg/L 3compartmentss NA 50% Human Human +DTXSID9021718 Css NA 0.3191 mg/L 3compartmentss NA 95% Human Human +DTXSID9021718 Css NA 0.03105 mg/L PBTK NA 50% Human Human +DTXSID9021718 Css NA 0.2403 mg/L PBTK NA 95% Human Human +DTXSID9021718 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021718 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021718 Vd NA 1.547 L/kg 1compartment NA NA Rat Human DTXSID9021718 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021718 TK.Half.Life NA 0.6897 hours 1compartment NA NA Rat Human -DTXSID9021718 Css NA 0.001488 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021718 Css NA 0.01925 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021718 Css NA 0.002438 mg/L PBTK NA 50% Rat Human -DTXSID9021718 Css NA 0.01905 mg/L PBTK NA 95% Rat Human +DTXSID9021718 TK.Half.Life NA 0.7295 hours 1compartment NA NA Rat Human +DTXSID9021718 Css NA 0.004063 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021718 Css NA 0.03057 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021718 Css NA 0.00384 mg/L PBTK NA 50% Rat Human +DTXSID9021718 Css NA 0.02307 mg/L PBTK NA 95% Rat Human DTXSID9021762 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021762 Fup NA 0.8377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021762 Vd NA 1.033 L/kg 1compartment NA NA Human Human DTXSID9021762 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9021762 TK.Half.Life NA 8.178 hours 1compartment NA NA Human Human -DTXSID9021762 Css NA 0.9215 mg/L 3compartmentss NA 50% Human Human -DTXSID9021762 Css NA 5.66 mg/L 3compartmentss NA 95% Human Human -DTXSID9021762 Css NA 0.8054 mg/L PBTK NA 50% Human Human -DTXSID9021762 Css NA 3.797 mg/L PBTK NA 95% Human Human +DTXSID9021762 Css NA 0.7777 mg/L 3compartmentss NA 50% Human Human +DTXSID9021762 Css NA 5.058 mg/L 3compartmentss NA 95% Human Human +DTXSID9021762 Css NA 0.6876 mg/L PBTK NA 50% Human Human +DTXSID9021762 Css NA 3.311 mg/L PBTK NA 95% Human Human DTXSID9021762 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021762 Fup NA 0.8377 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021762 Vd NA 1.004 L/kg 1compartment NA NA Rat Human DTXSID9021762 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9021762 TK.Half.Life NA 2.658 hours 1compartment NA NA Rat Human -DTXSID9021762 Css NA 0.2341 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021762 Css NA 1.439 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021762 Css NA 0.2003 mg/L PBTK NA 50% Rat Human -DTXSID9021762 Css NA 0.8807 mg/L PBTK NA 95% Rat Human +DTXSID9021762 Css NA 0.01467 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021762 Css NA 0.1072 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021762 Css NA 0.01248 mg/L PBTK NA 50% Rat Human +DTXSID9021762 Css NA 0.07325 mg/L PBTK NA 95% Rat Human DTXSID9021764 Clint NA 0.1044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021764 Fup NA 0.8148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021764 Vd NA 1.476 L/kg 1compartment NA NA Human Human DTXSID9021764 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9021764 TK.Half.Life NA 10.01 hours 1compartment NA NA Human Human -DTXSID9021764 Css NA 0.7103 mg/L 3compartmentss NA 50% Human Human -DTXSID9021764 Css NA 4.772 mg/L 3compartmentss NA 95% Human Human -DTXSID9021764 Css NA 0.6758 mg/L PBTK NA 50% Human Human -DTXSID9021764 Css NA 3.219 mg/L PBTK NA 95% Human Human +DTXSID9021764 Css NA 0.6017 mg/L 3compartmentss NA 50% Human Human +DTXSID9021764 Css NA 4.08 mg/L 3compartmentss NA 95% Human Human +DTXSID9021764 Css NA 0.5748 mg/L PBTK NA 50% Human Human +DTXSID9021764 Css NA 2.762 mg/L PBTK NA 95% Human Human DTXSID9021764 Clint NA 0.1044 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021764 Fup NA 0.8148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021764 Vd NA 1.495 L/kg 1compartment NA NA Rat Human DTXSID9021764 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9021764 TK.Half.Life NA 3.735 hours 1compartment NA NA Rat Human -DTXSID9021764 Css NA 0.1954 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021764 Css NA 1.369 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021764 Css NA 0.1835 mg/L PBTK NA 50% Rat Human -DTXSID9021764 Css NA 0.8567 mg/L PBTK NA 95% Rat Human -DTXSID9021841 Clint NA 20.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021841 Fup NA 0.5547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021841 Vd NA 1.463 L/kg 1compartment NA NA Human Human +DTXSID9021764 Css NA 0.01242 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021764 Css NA 0.1044 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021764 Css NA 0.01148 mg/L PBTK NA 50% Rat Human +DTXSID9021764 Css NA 0.07283 mg/L PBTK NA 95% Rat Human +DTXSID9021841 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021841 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021841 Vd NA 1.255 L/kg 1compartment NA NA Human Human DTXSID9021841 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021841 TK.Half.Life NA 1.402 hours 1compartment NA NA Human Human -DTXSID9021841 Css NA 0.04152 mg/L 3compartmentss NA 50% Human Human -DTXSID9021841 Css NA 0.4211 mg/L 3compartmentss NA 95% Human Human -DTXSID9021841 Css NA 0.03522 mg/L PBTK NA 50% Human Human -DTXSID9021841 Css NA 0.296 mg/L PBTK NA 95% Human Human -DTXSID9021841 Clint NA 20.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021841 Fup NA 0.5547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021841 Vd NA 1.258 L/kg 1compartment NA NA Rat Human +DTXSID9021841 TK.Half.Life NA 1.376 hours 1compartment NA NA Human Human +DTXSID9021841 Css NA 0.0474 mg/L 3compartmentss NA 50% Human Human +DTXSID9021841 Css NA 0.385 mg/L 3compartmentss NA 95% Human Human +DTXSID9021841 Css NA 0.03767 mg/L PBTK NA 50% Human Human +DTXSID9021841 Css NA 0.2735 mg/L PBTK NA 95% Human Human +DTXSID9021841 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021841 Fup 0.418 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021841 Vd NA 1.075 L/kg 1compartment NA NA Rat Human DTXSID9021841 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021841 TK.Half.Life NA 0.582 hours 1compartment NA NA Rat Human -DTXSID9021841 Css NA 0.02182 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021841 Css NA 0.1719 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021841 Css NA 0.01801 mg/L PBTK NA 50% Rat Human -DTXSID9021841 Css NA 0.1158 mg/L PBTK NA 95% Rat Human -DTXSID9021843 Clint NA 1.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021843 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021843 Vd NA 1.085 L/kg 1compartment NA NA Human Human +DTXSID9021841 TK.Half.Life NA 0.5864 hours 1compartment NA NA Rat Human +DTXSID9021841 Css NA 0.005956 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021841 Css NA 0.03571 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021841 Css NA 0.004732 mg/L PBTK NA 50% Rat Human +DTXSID9021841 Css NA 0.02518 mg/L PBTK NA 95% Rat Human +DTXSID9021843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021843 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021843 Vd NA 0.6308 L/kg 1compartment NA NA Human Human DTXSID9021843 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021843 TK.Half.Life NA 2.216 hours 1compartment NA NA Human Human -DTXSID9021843 Css NA 0.212 mg/L 3compartmentss NA 50% Human Human -DTXSID9021843 Css NA 1.631 mg/L 3compartmentss NA 95% Human Human -DTXSID9021843 Css NA 0.1899 mg/L PBTK NA 50% Human Human -DTXSID9021843 Css NA 1.133 mg/L PBTK NA 95% Human Human -DTXSID9021843 Clint NA 1.655 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021843 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021843 Vd NA 1.07 L/kg 1compartment NA NA Rat Human +DTXSID9021843 TK.Half.Life NA 0.7066 hours 1compartment NA NA Human Human +DTXSID9021843 Css NA 0.04824 mg/L 3compartmentss NA 50% Human Human +DTXSID9021843 Css NA 0.3838 mg/L 3compartmentss NA 95% Human Human +DTXSID9021843 Css NA 0.03568 mg/L PBTK NA 50% Human Human +DTXSID9021843 Css NA 0.2663 mg/L PBTK NA 95% Human Human +DTXSID9021843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021843 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021843 Vd NA 0.6186 L/kg 1compartment NA NA Rat Human DTXSID9021843 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021843 TK.Half.Life NA 1.095 hours 1compartment NA NA Rat Human -DTXSID9021843 Css NA 0.08585 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021843 Css NA 0.5795 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021843 Css NA 0.07674 mg/L PBTK NA 50% Rat Human -DTXSID9021843 Css NA 0.3682 mg/L PBTK NA 95% Rat Human -DTXSID9021897 Clint NA 1.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021897 Fup NA 0.9338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021897 Vd NA 1.569 L/kg 1compartment NA NA Human Human +DTXSID9021843 TK.Half.Life NA 0.3562 hours 1compartment NA NA Rat Human +DTXSID9021843 Css NA 0.006013 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021843 Css NA 0.03867 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021843 Css NA 0.004462 mg/L PBTK NA 50% Rat Human +DTXSID9021843 Css NA 0.0257 mg/L PBTK NA 95% Rat Human +DTXSID9021897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021897 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021897 Vd NA 1.075 L/kg 1compartment NA NA Human Human DTXSID9021897 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021897 TK.Half.Life NA 4.458 hours 1compartment NA NA Human Human -DTXSID9021897 Css NA 0.2878 mg/L 3compartmentss NA 50% Human Human -DTXSID9021897 Css NA 1.884 mg/L 3compartmentss NA 95% Human Human -DTXSID9021897 Css NA 0.2716 mg/L PBTK NA 50% Human Human -DTXSID9021897 Css NA 1.336 mg/L PBTK NA 95% Human Human -DTXSID9021897 Clint NA 1.135 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021897 Fup NA 0.9338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021897 Vd NA 1.454 L/kg 1compartment NA NA Rat Human +DTXSID9021897 TK.Half.Life NA 1.056 hours 1compartment NA NA Human Human +DTXSID9021897 Css NA 0.03024 mg/L 3compartmentss NA 50% Human Human +DTXSID9021897 Css NA 0.2942 mg/L 3compartmentss NA 95% Human Human +DTXSID9021897 Css NA 0.02479 mg/L PBTK NA 50% Human Human +DTXSID9021897 Css NA 0.2079 mg/L PBTK NA 95% Human Human +DTXSID9021897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021897 Fup 0.493 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021897 Vd NA 0.989 L/kg 1compartment NA NA Rat Human DTXSID9021897 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021897 TK.Half.Life NA 1.896 hours 1compartment NA NA Rat Human -DTXSID9021897 Css NA 0.1097 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021897 Css NA 0.6808 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021897 Css NA 0.1029 mg/L PBTK NA 50% Rat Human -DTXSID9021897 Css NA 0.434 mg/L PBTK NA 95% Rat Human -DTXSID9021899 Clint NA 1.445 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021899 Fup NA 0.9452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021899 Vd NA 1.502 L/kg 1compartment NA NA Human Human +DTXSID9021897 TK.Half.Life NA 0.4868 hours 1compartment NA NA Rat Human +DTXSID9021897 Css NA 0.001068 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021897 Css NA 0.012 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021897 Css NA 0.0008734 mg/L PBTK NA 50% Rat Human +DTXSID9021897 Css NA 0.008329 mg/L PBTK NA 95% Rat Human +DTXSID9021899 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021899 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021899 Vd NA 0.9939 L/kg 1compartment NA NA Human Human DTXSID9021899 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021899 TK.Half.Life NA 3.635 hours 1compartment NA NA Human Human -DTXSID9021899 Css NA 0.2432 mg/L 3compartmentss NA 50% Human Human -DTXSID9021899 Css NA 1.713 mg/L 3compartmentss NA 95% Human Human -DTXSID9021899 Css NA 0.2284 mg/L PBTK NA 50% Human Human -DTXSID9021899 Css NA 1.201 mg/L PBTK NA 95% Human Human -DTXSID9021899 Clint NA 1.445 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021899 Fup NA 0.9452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021899 Vd NA 1.404 L/kg 1compartment NA NA Rat Human +DTXSID9021899 TK.Half.Life NA 0.9988 hours 1compartment NA NA Human Human +DTXSID9021899 Css NA 0.03138 mg/L 3compartmentss NA 50% Human Human +DTXSID9021899 Css NA 0.3165 mg/L 3compartmentss NA 95% Human Human +DTXSID9021899 Css NA 0.0251 mg/L PBTK NA 50% Human Human +DTXSID9021899 Css NA 0.2189 mg/L PBTK NA 95% Human Human +DTXSID9021899 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021899 Fup 0.474 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021899 Vd NA 0.923 L/kg 1compartment NA NA Rat Human DTXSID9021899 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021899 TK.Half.Life NA 1.623 hours 1compartment NA NA Rat Human -DTXSID9021899 Css NA 0.09593 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021899 Css NA 0.6075 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021899 Css NA 0.08969 mg/L PBTK NA 50% Rat Human -DTXSID9021899 Css NA 0.3864 mg/L PBTK NA 95% Rat Human -DTXSID9021922 Clint NA 0.4299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021922 Fup NA 0.8314 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021922 Vd NA 1.422 L/kg 1compartment NA NA Human Human -DTXSID9021922 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021922 TK.Half.Life NA 6.595 hours 1compartment NA NA Human Human -DTXSID9021922 Css NA 0.4956 mg/L 3compartmentss NA 50% Human Human -DTXSID9021922 Css NA 3.193 mg/L 3compartmentss NA 95% Human Human -DTXSID9021922 Css NA 0.4644 mg/L PBTK NA 50% Human Human -DTXSID9021922 Css NA 2.152 mg/L PBTK NA 95% Human Human -DTXSID9021922 Clint NA 0.4299 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021922 Fup NA 0.8314 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021922 Vd NA 1.429 L/kg 1compartment NA NA Rat Human +DTXSID9021899 TK.Half.Life NA 0.4677 hours 1compartment NA NA Rat Human +DTXSID9021899 Css NA 0.001098 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021899 Css NA 0.01269 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021899 Css NA 0.0008766 mg/L PBTK NA 50% Rat Human +DTXSID9021899 Css NA 0.008647 mg/L PBTK NA 95% Rat Human +DTXSID9021922 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021922 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021922 Vd NA 0.9875 L/kg 1compartment NA NA Human Human +DTXSID9021922 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9021922 TK.Half.Life NA 16.01 hours 1compartment NA NA Human Human +DTXSID9021922 Css NA 1.398 mg/L 3compartmentss NA 50% Human Human +DTXSID9021922 Css NA 6.643 mg/L 3compartmentss NA 95% Human Human +DTXSID9021922 Css NA 1.13 mg/L PBTK NA 50% Human Human +DTXSID9021922 Css NA 4.394 mg/L PBTK NA 95% Human Human +DTXSID9021922 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021922 Fup 0.399 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021922 Vd NA 0.982 L/kg 1compartment NA NA Rat Human DTXSID9021922 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021922 TK.Half.Life NA 2.838 hours 1compartment NA NA Rat Human -DTXSID9021922 Css NA 0.1596 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021922 Css NA 1.034 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021922 Css NA 0.1479 mg/L PBTK NA 50% Rat Human -DTXSID9021922 Css NA 0.6521 mg/L PBTK NA 95% Rat Human +DTXSID9021922 TK.Half.Life NA 5.428 hours 1compartment NA NA Rat Human +DTXSID9021922 Css NA 0.02563 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021922 Css NA 0.1713 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021922 Css NA 0.02023 mg/L PBTK NA 50% Rat Human +DTXSID9021922 Css NA 0.1152 mg/L PBTK NA 95% Rat Human DTXSID9021924 Clint NA 2.414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021924 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9021924 Vd NA 1.174 L/kg 1compartment NA NA Human Human DTXSID9021924 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9021924 TK.Half.Life NA 1.949 hours 1compartment NA NA Human Human -DTXSID9021924 Css NA 0.1593 mg/L 3compartmentss NA 50% Human Human -DTXSID9021924 Css NA 1.233 mg/L 3compartmentss NA 95% Human Human -DTXSID9021924 Css NA 0.144 mg/L PBTK NA 50% Human Human -DTXSID9021924 Css NA 0.9122 mg/L PBTK NA 95% Human Human +DTXSID9021924 Css NA 0.1298 mg/L 3compartmentss NA 50% Human Human +DTXSID9021924 Css NA 1.007 mg/L 3compartmentss NA 95% Human Human +DTXSID9021924 Css NA 0.1183 mg/L PBTK NA 50% Human Human +DTXSID9021924 Css NA 0.7604 mg/L PBTK NA 95% Human Human DTXSID9021924 Clint NA 2.414 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9021924 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021924 Vd NA 1.14 L/kg 1compartment NA NA Rat Human +DTXSID9021924 Vd 2.2 1.14 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID9021924 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021924 TK.Half.Life NA 0.9694 hours 1compartment NA NA Rat Human -DTXSID9021924 Css NA 0.06734 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021924 Css NA 0.4615 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021924 Css NA 0.06128 mg/L PBTK NA 50% Rat Human -DTXSID9021924 Css NA 0.2948 mg/L PBTK NA 95% Rat Human -DTXSID9021928 Clint NA 71.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021928 Fup NA 0.8571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9021928 Vd NA 1.039 L/kg 1compartment NA NA Human Human +DTXSID9021924 TK.Half.Life 3.9 0.9694 hours 1compartment National Toxicology Program NA Rat Human +DTXSID9021924 Css 0.11 0.003778 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID9021924 Css 0.11 0.03747 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID9021924 Css 0.11 0.003421 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID9021924 Css 0.11 0.02732 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID9021928 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021928 Fup 0.847 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021928 Vd NA 0.9133 L/kg 1compartment NA NA Human Human DTXSID9021928 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9021928 TK.Half.Life NA 0.6301 hours 1compartment NA NA Human Human -DTXSID9021928 Css NA 0.008236 mg/L 3compartmentss NA 50% Human Human -DTXSID9021928 Css NA 0.08988 mg/L 3compartmentss NA 95% Human Human -DTXSID9021928 Css NA 0.007078 mg/L PBTK NA 50% Human Human -DTXSID9021928 Css NA 0.06558 mg/L PBTK NA 95% Human Human -DTXSID9021928 Clint NA 71.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021928 Fup NA 0.8571 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9021928 Vd NA 1.012 L/kg 1compartment NA NA Rat Human +DTXSID9021928 TK.Half.Life NA 0.6802 hours 1compartment NA NA Human Human +DTXSID9021928 Css NA 0.02486 mg/L 3compartmentss NA 50% Human Human +DTXSID9021928 Css NA 0.2602 mg/L 3compartmentss NA 95% Human Human +DTXSID9021928 Css NA 0.021 mg/L PBTK NA 50% Human Human +DTXSID9021928 Css NA 0.1881 mg/L PBTK NA 95% Human Human +DTXSID9021928 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021928 Fup 0.847 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021928 Vd NA 0.9124 L/kg 1compartment NA NA Rat Human DTXSID9021928 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9021928 TK.Half.Life NA 0.276 hours 1compartment NA NA Rat Human -DTXSID9021928 Css NA 0.004192 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021928 Css NA 0.03871 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021928 Css NA 0.0036 mg/L PBTK NA 50% Rat Human -DTXSID9021928 Css NA 0.02739 mg/L PBTK NA 95% Rat Human +DTXSID9021928 TK.Half.Life NA 0.3279 hours 1compartment NA NA Rat Human +DTXSID9021928 Css NA 0.002897 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021928 Css NA 0.02582 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021928 Css NA 0.002509 mg/L PBTK NA 50% Rat Human +DTXSID9021928 Css NA 0.01845 mg/L PBTK NA 95% Rat Human +DTXSID9021974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021974 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9021974 Vd NA 1.397 L/kg 1compartment NA NA Human Human +DTXSID9021974 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9021974 TK.Half.Life NA 3.032 hours 1compartment NA NA Human Human +DTXSID9021974 Css NA 0.1937 mg/L 3compartmentss NA 50% Human Human +DTXSID9021974 Css NA 1.526 mg/L 3compartmentss NA 95% Human Human +DTXSID9021974 Css NA 0.1318 mg/L PBTK NA 50% Human Human +DTXSID9021974 Css NA 0.969 mg/L PBTK NA 95% Human Human +DTXSID9021974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021974 Fup 0.144 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9021974 Vd NA 1.09 L/kg 1compartment NA NA Rat Human +DTXSID9021974 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9021974 TK.Half.Life NA 1.21 hours 1compartment NA NA Rat Human +DTXSID9021974 Css NA 0.02524 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021974 Css NA 0.1495 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021974 Css NA 0.01682 mg/L PBTK NA 50% Rat Human +DTXSID9021974 Css NA 0.09378 mg/L PBTK NA 95% Rat Human DTXSID9021976 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9021976 Fup 0.2957 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9021976 Vd NA 0.7345 L/kg 1compartment NA NA Human Human DTXSID9021976 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID9021976 TK.Half.Life NA 16.57 hours 1compartment NA NA Human Human -DTXSID9021976 Css NA 2.538 mg/L 3compartmentss NA 50% Human Human -DTXSID9021976 Css NA 10.5 mg/L 3compartmentss NA 95% Human Human -DTXSID9021976 Css NA 1.84 mg/L PBTK NA 50% Human Human -DTXSID9021976 Css NA 6.642 mg/L PBTK NA 95% Human Human +DTXSID9021976 Css NA 2.473 mg/L 3compartmentss NA 50% Human Human +DTXSID9021976 Css NA 9.962 mg/L 3compartmentss NA 95% Human Human +DTXSID9021976 Css NA 1.786 mg/L PBTK NA 50% Human Human +DTXSID9021976 Css NA 6.305 mg/L PBTK NA 95% Human Human DTXSID9021976 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9021976 Fup 0.2957 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9021976 Vd NA 0.6685 L/kg 1compartment NA NA Rat Human DTXSID9021976 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9021976 TK.Half.Life NA 5.023 hours 1compartment NA NA Rat Human -DTXSID9021976 Css NA 0.7093 mg/L 3compartmentss NA 50% Rat Human -DTXSID9021976 Css NA 2.329 mg/L 3compartmentss NA 95% Rat Human -DTXSID9021976 Css NA 0.4894 mg/L PBTK NA 50% Rat Human -DTXSID9021976 Css NA 1.381 mg/L PBTK NA 95% Rat Human -DTXSID9022027 Clint NA 6.659 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022027 Fup NA 0.8151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022027 Vd NA 1.316 L/kg 1compartment NA NA Human Human +DTXSID9021976 Css NA 0.1591 mg/L 3compartmentss NA 50% Rat Human +DTXSID9021976 Css NA 0.5384 mg/L 3compartmentss NA 95% Rat Human +DTXSID9021976 Css NA 0.1138 mg/L PBTK NA 50% Rat Human +DTXSID9021976 Css NA 0.33 mg/L PBTK NA 95% Rat Human +DTXSID9022027 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022027 Fup 0.412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022027 Vd NA 0.8823 L/kg 1compartment NA NA Human Human DTXSID9022027 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022027 TK.Half.Life NA 1.531 hours 1compartment NA NA Human Human -DTXSID9022027 Css NA 0.08229 mg/L 3compartmentss NA 50% Human Human -DTXSID9022027 Css NA 0.6863 mg/L 3compartmentss NA 95% Human Human -DTXSID9022027 Css NA 0.073 mg/L PBTK NA 50% Human Human -DTXSID9022027 Css NA 0.4995 mg/L PBTK NA 95% Human Human -DTXSID9022027 Clint NA 6.659 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022027 Fup NA 0.8151 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022027 Vd NA 1.21 L/kg 1compartment NA NA Rat Human +DTXSID9022027 TK.Half.Life NA 0.9642 hours 1compartment NA NA Human Human +DTXSID9022027 Css NA 0.03796 mg/L 3compartmentss NA 50% Human Human +DTXSID9022027 Css NA 0.3204 mg/L 3compartmentss NA 95% Human Human +DTXSID9022027 Css NA 0.02919 mg/L PBTK NA 50% Human Human +DTXSID9022027 Css NA 0.2278 mg/L PBTK NA 95% Human Human +DTXSID9022027 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022027 Fup 0.412 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022027 Vd NA 0.8061 L/kg 1compartment NA NA Rat Human DTXSID9022027 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022027 TK.Half.Life NA 0.7205 hours 1compartment NA NA Rat Human -DTXSID9022027 Css NA 0.03876 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022027 Css NA 0.2914 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022027 Css NA 0.03434 mg/L PBTK NA 50% Rat Human -DTXSID9022027 Css NA 0.191 mg/L PBTK NA 95% Rat Human -DTXSID9022100 Clint NA 29.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022100 Fup NA 0.188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022100 Vd NA 2.553 L/kg 1compartment NA NA Human Human +DTXSID9022027 TK.Half.Life NA 0.4492 hours 1compartment NA NA Rat Human +DTXSID9022027 Css NA 0.001309 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022027 Css NA 0.01311 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022027 Css NA 0.0009925 mg/L PBTK NA 50% Rat Human +DTXSID9022027 Css NA 0.008933 mg/L PBTK NA 95% Rat Human +DTXSID9022079 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9022079 Fup NA 0.0056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9022079 Vd NA 3.017 L/kg 1compartment NA NA Human Human +DTXSID9022079 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID9022079 TK.Half.Life NA 59240 hours 1compartment NA NA Human Human +DTXSID9022079 Css NA 2003 mg/L 3compartmentss NA 50% Human Human +DTXSID9022079 Css NA 5720 mg/L 3compartmentss NA 95% Human Human +DTXSID9022079 Css NA 1373 mg/L PBTK NA 50% Human Human +DTXSID9022079 Css NA 3676 mg/L PBTK NA 95% Human Human +DTXSID9022079 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9022079 Fup NA 0.0056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9022079 Vd NA 2.257 L/kg 1compartment NA NA Rat Human +DTXSID9022079 Days.Css NA 3276 Days PBTK NA NA Rat Human +DTXSID9022079 TK.Half.Life NA 4279 hours 1compartment NA NA Rat Human +DTXSID9022079 Css NA 35.07 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022079 Css NA 167.6 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022079 Css NA 22.98 mg/L PBTK NA 50% Rat Human +DTXSID9022079 Css NA 108.2 mg/L PBTK NA 95% Rat Human +DTXSID9022100 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022100 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022100 Vd NA 2.387 L/kg 1compartment NA NA Human Human DTXSID9022100 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022100 TK.Half.Life NA 6.043 hours 1compartment NA NA Human Human -DTXSID9022100 Css NA 0.1956 mg/L 3compartmentss NA 50% Human Human -DTXSID9022100 Css NA 1.241 mg/L 3compartmentss NA 95% Human Human -DTXSID9022100 Css NA 0.1412 mg/L PBTK NA 50% Human Human -DTXSID9022100 Css NA 0.8448 mg/L PBTK NA 95% Human Human -DTXSID9022100 Clint NA 29.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022100 Fup NA 0.188 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022100 Vd NA 1.94 L/kg 1compartment NA NA Rat Human +DTXSID9022100 TK.Half.Life NA 7.628 hours 1compartment NA NA Human Human +DTXSID9022100 Css NA 0.323 mg/L 3compartmentss NA 50% Human Human +DTXSID9022100 Css NA 2.234 mg/L 3compartmentss NA 95% Human Human +DTXSID9022100 Css NA 0.2255 mg/L PBTK NA 50% Human Human +DTXSID9022100 Css NA 1.49 mg/L PBTK NA 95% Human Human +DTXSID9022100 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022100 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022100 Vd NA 1.81 L/kg 1compartment NA NA Rat Human DTXSID9022100 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022100 TK.Half.Life NA 1.652 hours 1compartment NA NA Rat Human -DTXSID9022100 Css NA 0.1089 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022100 Css NA 0.5385 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022100 Css NA 0.07536 mg/L PBTK NA 50% Rat Human -DTXSID9022100 Css NA 0.3582 mg/L PBTK NA 95% Rat Human +DTXSID9022100 TK.Half.Life NA 2.179 hours 1compartment NA NA Rat Human +DTXSID9022100 Css NA 0.04103 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022100 Css NA 0.2144 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022100 Css NA 0.02828 mg/L PBTK NA 50% Rat Human +DTXSID9022100 Css NA 0.14 mg/L PBTK NA 95% Rat Human DTXSID9022310 Clint 15.4 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9022310 Fup 0.0553 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9022310 Vd NA 1.787 L/kg 1compartment NA NA Human Human DTXSID9022310 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9022310 TK.Half.Life NA 11.13 hours 1compartment NA NA Human Human -DTXSID9022310 Css NA 0.7188 mg/L 3compartmentss NA 50% Human Human -DTXSID9022310 Css NA 4.41 mg/L 3compartmentss NA 95% Human Human -DTXSID9022310 Css NA 0.476 mg/L PBTK NA 50% Human Human -DTXSID9022310 Css NA 2.815 mg/L PBTK NA 95% Human Human +DTXSID9022310 Css NA 0.668 mg/L 3compartmentss NA 50% Human Human +DTXSID9022310 Css NA 4.434 mg/L 3compartmentss NA 95% Human Human +DTXSID9022310 Css NA 0.4479 mg/L PBTK NA 50% Human Human +DTXSID9022310 Css NA 2.87 mg/L PBTK NA 95% Human Human DTXSID9022310 Clint 31.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9022310 Fup 0.0315 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9022310 Vd NA 1.054 L/kg 1compartment NA NA Rat Rat DTXSID9022310 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9022310 TK.Half.Life NA 2.658 hours 1compartment NA NA Rat Rat -DTXSID9022310 Css NA 0.3884 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9022310 Css NA 2.604 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9022310 Css NA 0.229 mg/L PBTK NA 50% Rat Rat -DTXSID9022310 Css NA 1.489 mg/L PBTK NA 95% Rat Rat +DTXSID9022310 Css NA 0.08334 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9022310 Css NA 0.6122 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9022310 Css NA 0.05105 mg/L PBTK NA 50% Rat Rat +DTXSID9022310 Css NA 0.3583 mg/L PBTK NA 95% Rat Rat DTXSID9022312 Clint 15.65 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9022312 Fup NA 0.0224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022312 Vd NA 3.063 L/kg 1compartment NA NA Human Human +DTXSID9022312 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022312 Vd NA 2.996 L/kg 1compartment NA NA Human Human DTXSID9022312 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID9022312 TK.Half.Life NA 95.59 hours 1compartment NA NA Human Human -DTXSID9022312 Css NA 3.927 mg/L 3compartmentss NA 50% Human Human -DTXSID9022312 Css NA 24.44 mg/L 3compartmentss NA 95% Human Human -DTXSID9022312 Css NA 2.728 mg/L PBTK NA 50% Human Human -DTXSID9022312 Css NA 16.39 mg/L PBTK NA 95% Human Human +DTXSID9022312 TK.Half.Life NA 96.59 hours 1compartment NA NA Human Human +DTXSID9022312 Css NA 4.055 mg/L 3compartmentss NA 50% Human Human +DTXSID9022312 Css NA 27.7 mg/L 3compartmentss NA 95% Human Human +DTXSID9022312 Css NA 2.771 mg/L PBTK NA 50% Human Human +DTXSID9022312 Css NA 18.45 mg/L PBTK NA 95% Human Human DTXSID9022312 Clint 15.65 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID9022312 Fup NA 0.0224 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022312 Vd NA 2.294 L/kg 1compartment NA NA Rat Human +DTXSID9022312 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022312 Vd NA 2.242 L/kg 1compartment NA NA Rat Human DTXSID9022312 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID9022312 TK.Half.Life NA 13.84 hours 1compartment NA NA Rat Human -DTXSID9022312 Css NA 2.171 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022312 Css NA 11.32 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022312 Css NA 1.436 mg/L PBTK NA 50% Rat Human -DTXSID9022312 Css NA 7.265 mg/L PBTK NA 95% Rat Human +DTXSID9022312 TK.Half.Life NA 15.16 hours 1compartment NA NA Rat Human +DTXSID9022312 Css NA 0.529 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022312 Css NA 3.036 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022312 Css NA 0.357 mg/L PBTK NA 50% Rat Human +DTXSID9022312 Css NA 2.065 mg/L PBTK NA 95% Rat Human DTXSID9022360 Clint 26.98 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9022360 Fup 0.01902 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9022360 Vd NA 7.252 L/kg 1compartment NA NA Human Human -DTXSID9022360 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID9022360 TK.Half.Life NA 108.3 hours 1compartment NA NA Human Human -DTXSID9022360 Css NA 0.4008 mg/L 3compartmentss NA 50% Human Human -DTXSID9022360 Css NA 3.527 mg/L 3compartmentss NA 95% Human Human -DTXSID9022360 Css NA 1.354 mg/L PBTK NA 50% Human Human -DTXSID9022360 Css NA 8.868 mg/L PBTK NA 95% Human Human +DTXSID9022360 Vd NA 11.6 L/kg 1compartment NA NA Human Human +DTXSID9022360 Days.Css NA 27 Days PBTK NA NA Human Human +DTXSID9022360 TK.Half.Life NA 131.3 hours 1compartment NA NA Human Human +DTXSID9022360 Css NA 0.164 mg/L 3compartmentss NA 50% Human Human +DTXSID9022360 Css NA 1.722 mg/L 3compartmentss NA 95% Human Human +DTXSID9022360 Css NA 1.059 mg/L PBTK NA 50% Human Human +DTXSID9022360 Css NA 7.237 mg/L PBTK NA 95% Human Human DTXSID9022360 Clint 169.2 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9022360 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID9022360 Css NA 0.04178 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9022360 Css NA 0.2579 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9022360 Css NA 0.008586 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9022360 Css NA 0.1221 mg/L 3compartmentss NA 95% Rat Rat DTXSID9022364 Clint 70.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9022364 Fup 0.0313 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9022364 Vd NA 1.903 L/kg 1compartment NA NA Human Human DTXSID9022364 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9022364 TK.Half.Life NA 5.466 hours 1compartment NA NA Human Human -DTXSID9022364 Css NA 0.2731 mg/L 3compartmentss NA 50% Human Human -DTXSID9022364 Css NA 1.948 mg/L 3compartmentss NA 95% Human Human -DTXSID9022364 Css NA 0.1793 mg/L PBTK NA 50% Human Human -DTXSID9022364 Css NA 1.236 mg/L PBTK NA 95% Human Human +DTXSID9022364 Css NA 0.2622 mg/L 3compartmentss NA 50% Human Human +DTXSID9022364 Css NA 1.891 mg/L 3compartmentss NA 95% Human Human +DTXSID9022364 Css NA 0.1726 mg/L PBTK NA 50% Human Human +DTXSID9022364 Css NA 1.205 mg/L PBTK NA 95% Human Human DTXSID9022364 Clint 104 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9022364 Fup 0.0265 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9022364 Vd NA 1.333 L/kg 1compartment NA NA Rat Rat DTXSID9022364 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9022364 TK.Half.Life NA 1.508 hours 1compartment NA NA Rat Rat -DTXSID9022364 Css NA 0.1453 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9022364 Css NA 1.03 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9022364 Css NA 0.08748 mg/L PBTK NA 50% Rat Rat -DTXSID9022364 Css NA 0.5911 mg/L PBTK NA 95% Rat Rat -DTXSID9022366 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022366 Fup NA 0.0861 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022366 Vd NA 1.082 L/kg 1compartment NA NA Human Human -DTXSID9022366 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID9022366 TK.Half.Life NA 95.7 hours 1compartment NA NA Human Human -DTXSID9022366 Css NA 13.14 mg/L 3compartmentss NA 50% Human Human -DTXSID9022366 Css NA 57.05 mg/L 3compartmentss NA 95% Human Human -DTXSID9022366 Css NA 8.521 mg/L PBTK NA 50% Human Human -DTXSID9022366 Css NA 34.13 mg/L PBTK NA 95% Human Human +DTXSID9022364 Css NA 0.03248 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9022364 Css NA 0.2532 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9022364 Css NA 0.02024 mg/L PBTK NA 50% Rat Rat +DTXSID9022364 Css NA 0.1503 mg/L PBTK NA 95% Rat Rat +DTXSID9022366 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022366 Fup 0.0989 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022366 Vd NA 1.161 L/kg 1compartment NA NA Human Human +DTXSID9022366 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022366 TK.Half.Life NA 3.135 hours 1compartment NA NA Human Human +DTXSID9022366 Css NA 0.2927 mg/L 3compartmentss NA 50% Human Human +DTXSID9022366 Css NA 2.351 mg/L 3compartmentss NA 95% Human Human +DTXSID9022366 Css NA 0.1906 mg/L PBTK NA 50% Human Human +DTXSID9022366 Css NA 1.447 mg/L PBTK NA 95% Human Human DTXSID9022366 Clint 8.3 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9022366 Fup 0.106 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9022366 Vd NA 0.9345 L/kg 1compartment NA NA Rat Rat DTXSID9022366 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9022366 TK.Half.Life NA 2.668 hours 1compartment NA NA Rat Rat -DTXSID9022366 Css NA 0.3782 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9022366 Css NA 1.965 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9022366 Css NA 0.2338 mg/L PBTK NA 50% Rat Rat -DTXSID9022366 Css NA 1.124 mg/L PBTK NA 95% Rat Rat +DTXSID9022366 Css NA 0.0849 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9022366 Css NA 0.4513 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9022366 Css NA 0.0544 mg/L PBTK NA 50% Rat Rat +DTXSID9022366 Css NA 0.268 mg/L PBTK NA 95% Rat Rat DTXSID9022445 Clint 25.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9022445 Fup NA 0.0758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022445 Vd NA 1.573 L/kg 1compartment NA NA Human Human +DTXSID9022445 Fup 0.0396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022445 Vd NA 1.165 L/kg 1compartment NA NA Human Human DTXSID9022445 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022445 TK.Half.Life NA 4.93 hours 1compartment NA NA Human Human -DTXSID9022445 Css NA 0.372 mg/L 3compartmentss NA 50% Human Human -DTXSID9022445 Css NA 2.812 mg/L 3compartmentss NA 95% Human Human -DTXSID9022445 Css NA 0.2422 mg/L PBTK NA 50% Human Human -DTXSID9022445 Css NA 1.743 mg/L PBTK NA 95% Human Human +DTXSID9022445 TK.Half.Life NA 5.411 hours 1compartment NA NA Human Human +DTXSID9022445 Css NA 0.657 mg/L 3compartmentss NA 50% Human Human +DTXSID9022445 Css NA 6.231 mg/L 3compartmentss NA 95% Human Human +DTXSID9022445 Css NA 0.411 mg/L PBTK NA 50% Human Human +DTXSID9022445 Css NA 3.746 mg/L PBTK NA 95% Human Human DTXSID9022445 Clint 25.5 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9022445 Fup NA 0.0758 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022445 Vd NA 1.192 L/kg 1compartment NA NA Rat Human +DTXSID9022445 Fup 0.0396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022445 Vd NA 0.8771 L/kg 1compartment NA NA Rat Human DTXSID9022445 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022445 TK.Half.Life NA 1.863 hours 1compartment NA NA Rat Human -DTXSID9022445 Css NA 0.2094 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022445 Css NA 1.208 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022445 Css NA 0.1291 mg/L PBTK NA 50% Rat Human -DTXSID9022445 Css NA 0.723 mg/L PBTK NA 95% Rat Human +DTXSID9022445 TK.Half.Life NA 2.273 hours 1compartment NA NA Rat Human +DTXSID9022445 Css NA 0.08697 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022445 Css NA 0.6379 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022445 Css NA 0.05264 mg/L PBTK NA 50% Rat Human +DTXSID9022445 Css NA 0.3702 mg/L PBTK NA 95% Rat Human +DTXSID9022520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022520 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022520 Vd NA 1.994 L/kg 1compartment NA NA Human Human +DTXSID9022520 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022520 TK.Half.Life NA 5.894 hours 1compartment NA NA Human Human +DTXSID9022520 Css NA 0.3092 mg/L 3compartmentss NA 50% Human Human +DTXSID9022520 Css NA 2.134 mg/L 3compartmentss NA 95% Human Human +DTXSID9022520 Css NA 0.2105 mg/L PBTK NA 50% Human Human +DTXSID9022520 Css NA 1.373 mg/L PBTK NA 95% Human Human +DTXSID9022520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022520 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022520 Vd NA 1.515 L/kg 1compartment NA NA Rat Human +DTXSID9022520 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9022520 TK.Half.Life NA 1.971 hours 1compartment NA NA Rat Human +DTXSID9022520 Css NA 0.03885 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022520 Css NA 0.2242 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022520 Css NA 0.0262 mg/L PBTK NA 50% Rat Human +DTXSID9022520 Css NA 0.1441 mg/L PBTK NA 95% Rat Human DTXSID9022522 Clint 345 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9022522 Fup 0.000435 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9022522 Vd NA 0.4749 L/kg 1compartment NA NA Human Human DTXSID9022522 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9022522 TK.Half.Life NA 5.955 hours 1compartment NA NA Human Human -DTXSID9022522 Css NA 2.093 mg/L 3compartmentss NA 50% Human Human -DTXSID9022522 Css NA 16.11 mg/L 3compartmentss NA 95% Human Human -DTXSID9022522 Css NA 1.224 mg/L PBTK NA 50% Human Human -DTXSID9022522 Css NA 9.473 mg/L PBTK NA 95% Human Human +DTXSID9022522 Css NA 2.045 mg/L 3compartmentss NA 50% Human Human +DTXSID9022522 Css NA 15.06 mg/L 3compartmentss NA 95% Human Human +DTXSID9022522 Css NA 1.199 mg/L PBTK NA 50% Human Human +DTXSID9022522 Css NA 8.885 mg/L PBTK NA 95% Human Human DTXSID9022522 Clint 345 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9022522 Fup 0.000435 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9022522 Vd NA 0.3545 L/kg 1compartment NA NA Rat Human DTXSID9022522 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9022522 TK.Half.Life NA 2.941 hours 1compartment NA NA Rat Human -DTXSID9022522 Css NA 1.259 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022522 Css NA 6.605 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022522 Css NA 0.6859 mg/L PBTK NA 50% Rat Human -DTXSID9022522 Css NA 3.588 mg/L PBTK NA 95% Rat Human -DTXSID9022524 Clint NA 14.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9022522 Css NA 0.2823 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022522 Css NA 1.51 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022522 Css NA 0.1593 mg/L PBTK NA 50% Rat Human +DTXSID9022522 Css NA 0.8491 mg/L PBTK NA 95% Rat Human +DTXSID9022524 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID9022524 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9022524 Vd NA 0.38 L/kg 1compartment NA NA Human Human DTXSID9022524 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022524 TK.Half.Life NA 0.5275 hours 1compartment NA NA Human Human -DTXSID9022524 Css NA 0.08469 mg/L 3compartmentss NA 50% Human Human -DTXSID9022524 Css NA 0.6062 mg/L 3compartmentss NA 95% Human Human -DTXSID9022524 Css NA 0.05778 mg/L PBTK NA 50% Human Human -DTXSID9022524 Css NA 0.3861 mg/L PBTK NA 95% Human Human -DTXSID9022524 Clint NA 14.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9022524 TK.Half.Life NA 1.035 hours 1compartment NA NA Human Human +DTXSID9022524 Css NA 0.2607 mg/L 3compartmentss NA 50% Human Human +DTXSID9022524 Css NA 1.53 mg/L 3compartmentss NA 95% Human Human +DTXSID9022524 Css NA 0.1786 mg/L PBTK NA 50% Human Human +DTXSID9022524 Css NA 0.9658 mg/L PBTK NA 95% Human Human +DTXSID9022524 Clint 4 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID9022524 Fup 0.4 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9022524 Vd NA 0.3858 L/kg 1compartment NA NA Rat Human DTXSID9022524 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022524 TK.Half.Life NA 0.2835 hours 1compartment NA NA Rat Human -DTXSID9022524 Css NA 0.04512 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022524 Css NA 0.2541 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022524 Css NA 0.02944 mg/L PBTK NA 50% Rat Human -DTXSID9022524 Css NA 0.1526 mg/L PBTK NA 95% Rat Human +DTXSID9022524 TK.Half.Life NA 0.5825 hours 1compartment NA NA Rat Human +DTXSID9022524 Css NA 0.02914 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022524 Css NA 0.13 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022524 Css NA 0.01973 mg/L PBTK NA 50% Rat Human +DTXSID9022524 Css NA 0.07856 mg/L PBTK NA 95% Rat Human DTXSID9022526 Clint 633 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9022526 Fup 0.00674 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9022526 Vd NA 0.9386 L/kg 1compartment NA NA Human Human DTXSID9022526 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9022526 TK.Half.Life NA 1.536 hours 1compartment NA NA Human Human -DTXSID9022526 Css NA 0.09244 mg/L 3compartmentss NA 50% Human Human -DTXSID9022526 Css NA 0.8212 mg/L 3compartmentss NA 95% Human Human -DTXSID9022526 Css NA 0.05598 mg/L PBTK NA 50% Human Human -DTXSID9022526 Css NA 0.4914 mg/L PBTK NA 95% Human Human +DTXSID9022526 Css NA 0.08694 mg/L 3compartmentss NA 50% Human Human +DTXSID9022526 Css NA 0.8373 mg/L 3compartmentss NA 95% Human Human +DTXSID9022526 Css NA 0.053 mg/L PBTK NA 50% Human Human +DTXSID9022526 Css NA 0.4856 mg/L PBTK NA 95% Human Human DTXSID9022526 Clint 633 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9022526 Fup 0.00674 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9022526 Vd NA 0.691 L/kg 1compartment NA NA Rat Human DTXSID9022526 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9022526 TK.Half.Life NA 0.5815 hours 1compartment NA NA Rat Human -DTXSID9022526 Css NA 0.05252 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022526 Css NA 0.3701 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022526 Css NA 0.0298 mg/L PBTK NA 50% Rat Human -DTXSID9022526 Css NA 0.2078 mg/L PBTK NA 95% Rat Human +DTXSID9022526 Css NA 0.01186 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022526 Css NA 0.08389 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022526 Css NA 0.006988 mg/L PBTK NA 50% Rat Human +DTXSID9022526 Css NA 0.04858 mg/L PBTK NA 95% Rat Human DTXSID9022528 Clint 57.24 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9022528 Fup 0.1057 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9022528 Vd NA 1.204 L/kg 1compartment NA NA Human Human DTXSID9022528 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9022528 TK.Half.Life NA 1.55 hours 1compartment NA NA Human Human -DTXSID9022528 Css NA 0.08893 mg/L 3compartmentss NA 50% Human Human -DTXSID9022528 Css NA 0.7934 mg/L 3compartmentss NA 95% Human Human -DTXSID9022528 Css NA 0.0728 mg/L PBTK NA 50% Human Human -DTXSID9022528 Css NA 0.574 mg/L PBTK NA 95% Human Human +DTXSID9022528 Css NA 0.07481 mg/L 3compartmentss NA 50% Human Human +DTXSID9022528 Css NA 0.59 mg/L 3compartmentss NA 95% Human Human +DTXSID9022528 Css NA 0.0678 mg/L PBTK NA 50% Human Human +DTXSID9022528 Css NA 0.5353 mg/L PBTK NA 95% Human Human DTXSID9022528 Clint 126 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9022528 Fup 0.1275 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9022528 Vd NA 1.029 L/kg 1compartment NA NA Rat Rat DTXSID9022528 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9022528 TK.Half.Life NA 0.4324 hours 1compartment NA NA Rat Rat -DTXSID9022528 Css NA 0.01914 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9022528 Css NA 0.1312 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9022528 Css NA 0.01502 mg/L PBTK NA 50% Rat Rat -DTXSID9022528 Css NA 0.09303 mg/L PBTK NA 95% Rat Rat +DTXSID9022528 Css NA 0.003491 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9022528 Css NA 0.02395 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9022528 Css NA 0.003286 mg/L PBTK NA 50% Rat Rat +DTXSID9022528 Css NA 0.02251 mg/L PBTK NA 95% Rat Rat +DTXSID90225664 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90225664 Fup 0.017 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90225664 Vd NA 2.645 L/kg 1compartment NA NA Human Human +DTXSID90225664 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID90225664 TK.Half.Life NA 39.07 hours 1compartment NA NA Human Human +DTXSID90225664 Css NA 2.003 mg/L 3compartmentss NA 50% Human Human +DTXSID90225664 Css NA 14.9 mg/L 3compartmentss NA 95% Human Human +DTXSID90225664 Css NA 1.344 mg/L PBTK NA 50% Human Human +DTXSID90225664 Css NA 9.542 mg/L PBTK NA 95% Human Human +DTXSID90225664 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90225664 Fup 0.017 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90225664 Vd NA 1.975 L/kg 1compartment NA NA Rat Human +DTXSID90225664 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID90225664 TK.Half.Life NA 8.697 hours 1compartment NA NA Rat Human +DTXSID90225664 Css NA 0.2608 mg/L 3compartmentss NA 50% Rat Human +DTXSID90225664 Css NA 1.591 mg/L 3compartmentss NA 95% Rat Human +DTXSID90225664 Css NA 0.1711 mg/L PBTK NA 50% Rat Human +DTXSID90225664 Css NA 1.016 mg/L PBTK NA 95% Rat Human DTXSID9022570 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID9022570 Fup 0.086 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9022570 Vd NA 0.368 L/kg 1compartment NA NA Human Human DTXSID9022570 Days.Css NA 4 Days PBTK NA NA Human Human DTXSID9022570 TK.Half.Life NA 27.96 hours 1compartment NA NA Human Human -DTXSID9022570 Css NA 11.66 mg/L 3compartmentss NA 50% Human Human -DTXSID9022570 Css NA 54.24 mg/L 3compartmentss NA 95% Human Human -DTXSID9022570 Css NA 7.422 mg/L PBTK NA 50% Human Human -DTXSID9022570 Css NA 32.16 mg/L PBTK NA 95% Human Human +DTXSID9022570 Css NA 11.41 mg/L 3compartmentss NA 50% Human Human +DTXSID9022570 Css NA 49.18 mg/L 3compartmentss NA 95% Human Human +DTXSID9022570 Css NA 7.186 mg/L PBTK NA 50% Human Human +DTXSID9022570 Css NA 30.98 mg/L PBTK NA 95% Human Human DTXSID9022570 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID9022570 Fup 0.11 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID9022570 Vd NA 0.3647 L/kg 1compartment NA NA Rat Rat DTXSID9022570 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9022570 TK.Half.Life NA 7.329 hours 1compartment NA NA Rat Rat -DTXSID9022570 Css NA 2.516 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9022570 Css NA 9.941 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9022570 Css NA 1.506 mg/L PBTK NA 50% Rat Rat -DTXSID9022570 Css NA 5.527 mg/L PBTK NA 95% Rat Rat -DTXSID9022574 Clint NA 15.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022574 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022574 Vd NA 3.112 L/kg 1compartment NA NA Human Human -DTXSID9022574 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID9022574 TK.Half.Life NA 118.2 hours 1compartment NA NA Human Human -DTXSID9022574 Css NA 4.662 mg/L 3compartmentss NA 50% Human Human -DTXSID9022574 Css NA 28.43 mg/L 3compartmentss NA 95% Human Human -DTXSID9022574 Css NA 3.207 mg/L PBTK NA 50% Human Human -DTXSID9022574 Css NA 18.93 mg/L PBTK NA 95% Human Human -DTXSID9022574 Clint NA 15.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022574 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022574 Vd NA 2.331 L/kg 1compartment NA NA Rat Human -DTXSID9022574 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID9022574 TK.Half.Life NA 15.95 hours 1compartment NA NA Rat Human -DTXSID9022574 Css NA 2.633 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022574 Css NA 12.43 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022574 Css NA 1.743 mg/L PBTK NA 50% Rat Human -DTXSID9022574 Css NA 8 mg/L PBTK NA 95% Rat Human -DTXSID9022576 Clint NA 21.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022576 Fup NA 0.0917 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022576 Vd NA 1.937 L/kg 1compartment NA NA Human Human +DTXSID9022570 Css NA 0.5376 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9022570 Css NA 1.981 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9022570 Css NA 0.3506 mg/L PBTK NA 50% Rat Rat +DTXSID9022570 Css NA 1.293 mg/L PBTK NA 95% Rat Rat +DTXSID9022574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022574 Fup 0.0297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022574 Vd NA 3.042 L/kg 1compartment NA NA Human Human +DTXSID9022574 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID9022574 TK.Half.Life NA 59.6 hours 1compartment NA NA Human Human +DTXSID9022574 Css NA 2.364 mg/L 3compartmentss NA 50% Human Human +DTXSID9022574 Css NA 16.45 mg/L 3compartmentss NA 95% Human Human +DTXSID9022574 Css NA 1.631 mg/L PBTK NA 50% Human Human +DTXSID9022574 Css NA 10.99 mg/L PBTK NA 95% Human Human +DTXSID9022574 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022574 Fup 0.0297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022574 Vd NA 2.279 L/kg 1compartment NA NA Rat Human +DTXSID9022574 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID9022574 TK.Half.Life NA 9.058 hours 1compartment NA NA Rat Human +DTXSID9022574 Css NA 0.3094 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022574 Css NA 1.795 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022574 Css NA 0.2114 mg/L PBTK NA 50% Rat Human +DTXSID9022574 Css NA 1.201 mg/L PBTK NA 95% Rat Human +DTXSID9022576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022576 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022576 Vd NA 1.775 L/kg 1compartment NA NA Human Human DTXSID9022576 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022576 TK.Half.Life NA 6.691 hours 1compartment NA NA Human Human -DTXSID9022576 Css NA 0.4028 mg/L 3compartmentss NA 50% Human Human -DTXSID9022576 Css NA 2.905 mg/L 3compartmentss NA 95% Human Human -DTXSID9022576 Css NA 0.27 mg/L PBTK NA 50% Human Human -DTXSID9022576 Css NA 1.876 mg/L PBTK NA 95% Human Human -DTXSID9022576 Clint NA 21.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022576 Fup NA 0.0917 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022576 Vd NA 1.466 L/kg 1compartment NA NA Rat Human +DTXSID9022576 TK.Half.Life NA 5.39 hours 1compartment NA NA Human Human +DTXSID9022576 Css NA 0.3326 mg/L 3compartmentss NA 50% Human Human +DTXSID9022576 Css NA 2.392 mg/L 3compartmentss NA 95% Human Human +DTXSID9022576 Css NA 0.2228 mg/L PBTK NA 50% Human Human +DTXSID9022576 Css NA 1.52 mg/L PBTK NA 95% Human Human +DTXSID9022576 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022576 Fup 0.101 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022576 Vd NA 1.35 L/kg 1compartment NA NA Rat Human DTXSID9022576 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022576 TK.Half.Life NA 2.267 hours 1compartment NA NA Rat Human -DTXSID9022576 Css NA 0.2225 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022576 Css NA 1.259 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022576 Css NA 0.142 mg/L PBTK NA 50% Rat Human -DTXSID9022576 Css NA 0.7529 mg/L PBTK NA 95% Rat Human -DTXSID9022578 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022578 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022578 Vd NA 0.3567 L/kg 1compartment NA NA Human Human -DTXSID9022578 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9022578 TK.Half.Life NA 29.61 hours 1compartment NA NA Human Human -DTXSID9022578 Css NA 12.99 mg/L 3compartmentss NA 50% Human Human -DTXSID9022578 Css NA 58.71 mg/L 3compartmentss NA 95% Human Human -DTXSID9022578 Css NA 8.214 mg/L PBTK NA 50% Human Human -DTXSID9022578 Css NA 34.86 mg/L PBTK NA 95% Human Human -DTXSID9022578 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022578 Fup NA 0.0781 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022578 Vd NA 0.3433 L/kg 1compartment NA NA Rat Human -DTXSID9022578 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9022578 TK.Half.Life NA 9.697 hours 1compartment NA NA Rat Human -DTXSID9022578 Css NA 3.62 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022578 Css NA 14.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022578 Css NA 2.151 mg/L PBTK NA 50% Rat Human -DTXSID9022578 Css NA 7.936 mg/L PBTK NA 95% Rat Human +DTXSID9022576 TK.Half.Life NA 1.932 hours 1compartment NA NA Rat Human +DTXSID9022576 Css NA 0.04266 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022576 Css NA 0.2436 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022576 Css NA 0.02797 mg/L PBTK NA 50% Rat Human +DTXSID9022576 Css NA 0.1539 mg/L PBTK NA 95% Rat Human +DTXSID9022578 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022578 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022578 Vd NA 0.4052 L/kg 1compartment NA NA Human Human +DTXSID9022578 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022578 TK.Half.Life NA 1.013 hours 1compartment NA NA Human Human +DTXSID9022578 Css NA 0.2316 mg/L 3compartmentss NA 50% Human Human +DTXSID9022578 Css NA 1.997 mg/L 3compartmentss NA 95% Human Human +DTXSID9022578 Css NA 0.1514 mg/L PBTK NA 50% Human Human +DTXSID9022578 Css NA 1.237 mg/L PBTK NA 95% Human Human +DTXSID9022578 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022578 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022578 Vd NA 0.3906 L/kg 1compartment NA NA Rat Human +DTXSID9022578 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9022578 TK.Half.Life NA 0.581 hours 1compartment NA NA Rat Human +DTXSID9022578 Css NA 0.01097 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022578 Css NA 0.1039 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022578 Css NA 0.006998 mg/L PBTK NA 50% Rat Human +DTXSID9022578 Css NA 0.06115 mg/L PBTK NA 95% Rat Human DTXSID9022601 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9022601 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9022601 Vd NA 0.1935 L/kg 1compartment NA NA Human Human +DTXSID9022601 Vd NA 0.1888 L/kg 1compartment NA NA Human Human DTXSID9022601 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID9022601 TK.Half.Life NA 41.76 hours 1compartment NA NA Human Human -DTXSID9022601 Css NA 37.32 mg/L 3compartmentss NA 50% Human Human -DTXSID9022601 Css NA 218.9 mg/L 3compartmentss NA 95% Human Human -DTXSID9022601 Css NA 21.84 mg/L PBTK NA 50% Human Human -DTXSID9022601 Css NA 125.3 mg/L PBTK NA 95% Human Human +DTXSID9022601 TK.Half.Life NA 40.73 hours 1compartment NA NA Human Human +DTXSID9022601 Css NA 32.02 mg/L 3compartmentss NA 50% Human Human +DTXSID9022601 Css NA 189.6 mg/L 3compartmentss NA 95% Human Human +DTXSID9022601 Css NA 18.84 mg/L PBTK NA 50% Human Human +DTXSID9022601 Css NA 109.2 mg/L PBTK NA 95% Human Human DTXSID9022601 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9022601 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9022601 Vd NA 0.1906 L/kg 1compartment NA NA Rat Human +DTXSID9022601 Vd NA 0.187 L/kg 1compartment NA NA Rat Human DTXSID9022601 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9022601 TK.Half.Life NA 14.01 hours 1compartment NA NA Rat Human -DTXSID9022601 Css NA 10.63 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022601 Css NA 52.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022601 Css NA 5.824 mg/L PBTK NA 50% Rat Human -DTXSID9022601 Css NA 28.66 mg/L PBTK NA 95% Rat Human -DTXSID9022603 Clint NA 2.149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9022601 TK.Half.Life NA 13.74 hours 1compartment NA NA Rat Human +DTXSID9022601 Css NA 0.5984 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022601 Css NA 4.76 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022601 Css NA 0.3321 mg/L PBTK NA 50% Rat Human +DTXSID9022601 Css NA 2.627 mg/L PBTK NA 95% Rat Human +DTXSID9022603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9022603 Fup 0.89 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9022603 Vd NA 1.299 L/kg 1compartment NA NA Human Human -DTXSID9022603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022603 TK.Half.Life NA 2.612 hours 1compartment NA NA Human Human -DTXSID9022603 Css NA 0.198 mg/L 3compartmentss NA 50% Human Human -DTXSID9022603 Css NA 1.411 mg/L 3compartmentss NA 95% Human Human -DTXSID9022603 Css NA 0.1784 mg/L PBTK NA 50% Human Human -DTXSID9022603 Css NA 0.9853 mg/L PBTK NA 95% Human Human -DTXSID9022603 Clint NA 2.149 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9022603 Vd NA 1.475 L/kg 1compartment NA NA Human Human +DTXSID9022603 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9022603 TK.Half.Life NA 11.75 hours 1compartment NA NA Human Human +DTXSID9022603 Css NA 0.8238 mg/L 3compartmentss NA 50% Human Human +DTXSID9022603 Css NA 5.039 mg/L 3compartmentss NA 95% Human Human +DTXSID9022603 Css NA 0.7694 mg/L PBTK NA 50% Human Human +DTXSID9022603 Css NA 3.489 mg/L PBTK NA 95% Human Human +DTXSID9022603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9022603 Fup 0.89 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9022603 Vd NA 1.213 L/kg 1compartment NA NA Rat Human +DTXSID9022603 Vd NA 1.364 L/kg 1compartment NA NA Rat Human DTXSID9022603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022603 TK.Half.Life NA 1.223 hours 1compartment NA NA Rat Human -DTXSID9022603 Css NA 0.08222 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022603 Css NA 0.5288 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022603 Css NA 0.07376 mg/L PBTK NA 50% Rat Human -DTXSID9022603 Css NA 0.3359 mg/L PBTK NA 95% Rat Human -DTXSID9022607 Clint NA 2.951 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022607 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022607 Vd NA 1.579 L/kg 1compartment NA NA Human Human -DTXSID9022607 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9022607 TK.Half.Life NA 18.73 hours 1compartment NA NA Human Human -DTXSID9022607 Css NA 1.651 mg/L 3compartmentss NA 50% Human Human -DTXSID9022607 Css NA 9.262 mg/L 3compartmentss NA 95% Human Human -DTXSID9022607 Css NA 1.118 mg/L PBTK NA 50% Human Human -DTXSID9022607 Css NA 5.782 mg/L PBTK NA 95% Human Human -DTXSID9022607 Clint NA 2.951 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022607 Fup NA 0.1208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022607 Vd NA 1.213 L/kg 1compartment NA NA Rat Human +DTXSID9022603 TK.Half.Life NA 3.457 hours 1compartment NA NA Rat Human +DTXSID9022603 Css NA 0.0487 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022603 Css NA 0.2984 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022603 Css NA 0.04637 mg/L PBTK NA 50% Rat Human +DTXSID9022603 Css NA 0.1949 mg/L PBTK NA 95% Rat Human +DTXSID9022607 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022607 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022607 Vd NA 1.882 L/kg 1compartment NA NA Human Human +DTXSID9022607 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022607 TK.Half.Life NA 6.054 hours 1compartment NA NA Human Human +DTXSID9022607 Css NA 0.289 mg/L 3compartmentss NA 50% Human Human +DTXSID9022607 Css NA 1.717 mg/L 3compartmentss NA 95% Human Human +DTXSID9022607 Css NA 0.2214 mg/L PBTK NA 50% Human Human +DTXSID9022607 Css NA 1.186 mg/L PBTK NA 95% Human Human +DTXSID9022607 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022607 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022607 Vd NA 1.487 L/kg 1compartment NA NA Rat Human DTXSID9022607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022607 TK.Half.Life NA 6.658 hours 1compartment NA NA Rat Human -DTXSID9022607 Css NA 0.8094 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022607 Css NA 3.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022607 Css NA 0.5184 mg/L PBTK NA 50% Rat Human -DTXSID9022607 Css NA 1.976 mg/L PBTK NA 95% Rat Human -DTXSID9022609 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022609 Fup NA 0.0762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022609 Vd NA 2.452 L/kg 1compartment NA NA Human Human -DTXSID9022609 Days.Css NA 150 Days PBTK NA NA Human Human -DTXSID9022609 TK.Half.Life NA 615.6 hours 1compartment NA NA Human Human -DTXSID9022609 Css NA 32.94 mg/L 3compartmentss NA 50% Human Human -DTXSID9022609 Css NA 106.1 mg/L 3compartmentss NA 95% Human Human -DTXSID9022609 Css NA 22.37 mg/L PBTK NA 50% Human Human -DTXSID9022609 Css NA 66.48 mg/L PBTK NA 95% Human Human -DTXSID9022609 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022609 Fup NA 0.0762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022609 Vd NA 1.843 L/kg 1compartment NA NA Rat Human -DTXSID9022609 Days.Css NA 36 Days PBTK NA NA Rat Human -DTXSID9022609 TK.Half.Life NA 78.22 hours 1compartment NA NA Rat Human -DTXSID9022609 Css NA 8.944 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022609 Css NA 23.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022609 Css NA 5.79 mg/L PBTK NA 50% Rat Human -DTXSID9022609 Css NA 13.92 mg/L PBTK NA 95% Rat Human +DTXSID9022607 TK.Half.Life NA 2.156 hours 1compartment NA NA Rat Human +DTXSID9022607 Css NA 0.03417 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022607 Css NA 0.1439 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022607 Css NA 0.02617 mg/L PBTK NA 50% Rat Human +DTXSID9022607 Css NA 0.09874 mg/L PBTK NA 95% Rat Human +DTXSID9022609 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022609 Fup 0.0914 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022609 Vd NA 2.545 L/kg 1compartment NA NA Human Human +DTXSID9022609 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022609 TK.Half.Life NA 12.46 hours 1compartment NA NA Human Human +DTXSID9022609 Css NA 0.559 mg/L 3compartmentss NA 50% Human Human +DTXSID9022609 Css NA 3.563 mg/L 3compartmentss NA 95% Human Human +DTXSID9022609 Css NA 0.3834 mg/L PBTK NA 50% Human Human +DTXSID9022609 Css NA 2.354 mg/L PBTK NA 95% Human Human +DTXSID9022609 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022609 Fup 0.0914 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022609 Vd NA 1.916 L/kg 1compartment NA NA Rat Human +DTXSID9022609 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9022609 TK.Half.Life NA 3.162 hours 1compartment NA NA Rat Human +DTXSID9022609 Css NA 0.0721 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022609 Css NA 0.3891 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022609 Css NA 0.0487 mg/L PBTK NA 50% Rat Human +DTXSID9022609 Css NA 0.2562 mg/L PBTK NA 95% Rat Human DTXSID9022655 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9022655 Fup NA 0.0873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022655 Vd NA 1.051 L/kg 1compartment NA NA Human Human +DTXSID9022655 Vd NA 1.05 L/kg 1compartment NA NA Human Human DTXSID9022655 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID9022655 TK.Half.Life NA 90.79 hours 1compartment NA NA Human Human -DTXSID9022655 Css NA 12.85 mg/L 3compartmentss NA 50% Human Human -DTXSID9022655 Css NA 55.29 mg/L 3compartmentss NA 95% Human Human -DTXSID9022655 Css NA 8.277 mg/L PBTK NA 50% Human Human -DTXSID9022655 Css NA 33.41 mg/L PBTK NA 95% Human Human +DTXSID9022655 TK.Half.Life NA 90.7 hours 1compartment NA NA Human Human +DTXSID9022655 Css NA 11.12 mg/L 3compartmentss NA 50% Human Human +DTXSID9022655 Css NA 48.87 mg/L 3compartmentss NA 95% Human Human +DTXSID9022655 Css NA 7.155 mg/L PBTK NA 50% Human Human +DTXSID9022655 Css NA 29.43 mg/L PBTK NA 95% Human Human DTXSID9022655 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9022655 Fup NA 0.0873 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9022655 Vd NA 0.8168 L/kg 1compartment NA NA Rat Human DTXSID9022655 Days.Css NA 3 Days PBTK NA NA Rat Human DTXSID9022655 TK.Half.Life NA 21.45 hours 1compartment NA NA Rat Human -DTXSID9022655 Css NA 3.652 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022655 Css NA 13.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022655 Css NA 2.206 mg/L PBTK NA 50% Rat Human -DTXSID9022655 Css NA 7.319 mg/L PBTK NA 95% Rat Human -DTXSID9022657 Clint NA 84.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022657 Fup NA 0.1041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022657 Vd NA 0.6011 L/kg 1compartment NA NA Human Human +DTXSID9022655 Css NA 0.2694 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022655 Css NA 1.635 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022655 Css NA 0.1694 mg/L PBTK NA 50% Rat Human +DTXSID9022655 Css NA 0.9565 mg/L PBTK NA 95% Rat Human +DTXSID9022657 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022657 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022657 Vd NA 1.532 L/kg 1compartment NA NA Human Human DTXSID9022657 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022657 TK.Half.Life NA 0.7723 hours 1compartment NA NA Human Human -DTXSID9022657 Css NA 0.07239 mg/L 3compartmentss NA 50% Human Human -DTXSID9022657 Css NA 0.6338 mg/L 3compartmentss NA 95% Human Human -DTXSID9022657 Css NA 0.04677 mg/L PBTK NA 50% Human Human -DTXSID9022657 Css NA 0.3958 mg/L PBTK NA 95% Human Human -DTXSID9022657 Clint NA 84.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022657 Fup NA 0.1041 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022657 Vd NA 0.586 L/kg 1compartment NA NA Rat Human +DTXSID9022657 TK.Half.Life NA 2.79 hours 1compartment NA NA Human Human +DTXSID9022657 Css NA 0.1258 mg/L 3compartmentss NA 50% Human Human +DTXSID9022657 Css NA 0.9582 mg/L 3compartmentss NA 95% Human Human +DTXSID9022657 Css NA 0.1134 mg/L PBTK NA 50% Human Human +DTXSID9022657 Css NA 0.7114 mg/L PBTK NA 95% Human Human +DTXSID9022657 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022657 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022657 Vd NA 1.519 L/kg 1compartment NA NA Rat Human DTXSID9022657 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022657 TK.Half.Life NA 0.3927 hours 1compartment NA NA Rat Human -DTXSID9022657 Css NA 0.04098 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022657 Css NA 0.285 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022657 Css NA 0.02498 mg/L PBTK NA 50% Rat Human -DTXSID9022657 Css NA 0.1645 mg/L PBTK NA 95% Rat Human -DTXSID9022659 Clint NA 7.361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022659 Fup NA 0.1197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022659 Vd NA 3.492 L/kg 1compartment NA NA Human Human +DTXSID9022657 TK.Half.Life NA 1.571 hours 1compartment NA NA Rat Human +DTXSID9022657 Css NA 0.01436 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022657 Css NA 0.0855 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022657 Css NA 0.01308 mg/L PBTK NA 50% Rat Human +DTXSID9022657 Css NA 0.06003 mg/L PBTK NA 95% Rat Human +DTXSID9022659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022659 Fup 0.0703 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022659 Vd NA 2.832 L/kg 1compartment NA NA Human Human DTXSID9022659 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022659 TK.Half.Life NA 11.17 hours 1compartment NA NA Human Human -DTXSID9022659 Css NA 0.2876 mg/L 3compartmentss NA 50% Human Human -DTXSID9022659 Css NA 2.384 mg/L 3compartmentss NA 95% Human Human -DTXSID9022659 Css NA 0.2766 mg/L PBTK NA 50% Human Human -DTXSID9022659 Css NA 1.886 mg/L PBTK NA 95% Human Human -DTXSID9022659 Clint NA 7.361 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022659 Fup NA 0.1197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022659 Vd NA 3.317 L/kg 1compartment NA NA Rat Human +DTXSID9022659 TK.Half.Life NA 5.501 hours 1compartment NA NA Human Human +DTXSID9022659 Css NA 0.1581 mg/L 3compartmentss NA 50% Human Human +DTXSID9022659 Css NA 1.379 mg/L 3compartmentss NA 95% Human Human +DTXSID9022659 Css NA 0.1324 mg/L PBTK NA 50% Human Human +DTXSID9022659 Css NA 1.018 mg/L PBTK NA 95% Human Human +DTXSID9022659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022659 Fup 0.0703 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022659 Vd NA 2.628 L/kg 1compartment NA NA Rat Human DTXSID9022659 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022659 TK.Half.Life NA 5.484 hours 1compartment NA NA Rat Human -DTXSID9022659 Css NA 0.1532 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022659 Css NA 0.9512 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022659 Css NA 0.1428 mg/L PBTK NA 50% Rat Human -DTXSID9022659 Css NA 0.7229 mg/L PBTK NA 95% Rat Human -DTXSID9022730 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022730 Fup NA 0.8768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022730 Vd NA 1.078 L/kg 1compartment NA NA Human Human +DTXSID9022659 TK.Half.Life NA 2.666 hours 1compartment NA NA Rat Human +DTXSID9022659 Css NA 0.0203 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022659 Css NA 0.1407 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022659 Css NA 0.01711 mg/L PBTK NA 50% Rat Human +DTXSID9022659 Css NA 0.1032 mg/L PBTK NA 95% Rat Human +DTXSID9022730 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022730 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022730 Vd NA 0.6058 L/kg 1compartment NA NA Human Human DTXSID9022730 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022730 TK.Half.Life NA 8.01 hours 1compartment NA NA Human Human -DTXSID9022730 Css NA 0.8793 mg/L 3compartmentss NA 50% Human Human -DTXSID9022730 Css NA 5.235 mg/L 3compartmentss NA 95% Human Human -DTXSID9022730 Css NA 0.7745 mg/L PBTK NA 50% Human Human -DTXSID9022730 Css NA 3.5 mg/L PBTK NA 95% Human Human -DTXSID9022730 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022730 Fup NA 0.8768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022730 Vd NA 1.087 L/kg 1compartment NA NA Rat Human +DTXSID9022730 TK.Half.Life NA 8.152 hours 1compartment NA NA Human Human +DTXSID9022730 Css NA 1.272 mg/L 3compartmentss NA 50% Human Human +DTXSID9022730 Css NA 6.513 mg/L 3compartmentss NA 95% Human Human +DTXSID9022730 Css NA 0.9602 mg/L PBTK NA 50% Human Human +DTXSID9022730 Css NA 4.148 mg/L PBTK NA 95% Human Human +DTXSID9022730 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022730 Fup 0.481 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022730 Vd NA 0.6242 L/kg 1compartment NA NA Rat Human DTXSID9022730 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022730 TK.Half.Life NA 2.738 hours 1compartment NA NA Rat Human -DTXSID9022730 Css NA 0.2267 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022730 Css NA 1.344 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022730 Css NA 0.1942 mg/L PBTK NA 50% Rat Human -DTXSID9022730 Css NA 0.8258 mg/L PBTK NA 95% Rat Human -DTXSID9022732 Clint NA 0.05592 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022732 Fup NA 0.7348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022732 Vd NA 0.4812 L/kg 1compartment NA NA Human Human +DTXSID9022730 TK.Half.Life NA 2.862 hours 1compartment NA NA Rat Human +DTXSID9022730 Css NA 0.02386 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022730 Css NA 0.1623 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022730 Css NA 0.01725 mg/L PBTK NA 50% Rat Human +DTXSID9022730 Css NA 0.1045 mg/L PBTK NA 95% Rat Human +DTXSID9022732 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022732 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022732 Vd NA 0.408 L/kg 1compartment NA NA Human Human DTXSID9022732 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022732 TK.Half.Life NA 3.879 hours 1compartment NA NA Human Human -DTXSID9022732 Css NA 1.044 mg/L 3compartmentss NA 50% Human Human -DTXSID9022732 Css NA 6.039 mg/L 3compartmentss NA 95% Human Human -DTXSID9022732 Css NA 0.7746 mg/L PBTK NA 50% Human Human -DTXSID9022732 Css NA 3.781 mg/L PBTK NA 95% Human Human -DTXSID9022732 Clint NA 0.05592 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022732 Fup NA 0.7348 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022732 Vd NA 0.5012 L/kg 1compartment NA NA Rat Human +DTXSID9022732 TK.Half.Life NA 4.64 hours 1compartment NA NA Human Human +DTXSID9022732 Css NA 0.7762 mg/L 3compartmentss NA 50% Human Human +DTXSID9022732 Css NA 5.182 mg/L 3compartmentss NA 95% Human Human +DTXSID9022732 Css NA 0.5558 mg/L PBTK NA 50% Human Human +DTXSID9022732 Css NA 3.213 mg/L PBTK NA 95% Human Human +DTXSID9022732 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022732 Fup 0.569 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022732 Vd NA 0.4265 L/kg 1compartment NA NA Rat Human DTXSID9022732 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022732 TK.Half.Life NA 1.439 hours 1compartment NA NA Rat Human -DTXSID9022732 Css NA 0.2878 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022732 Css NA 1.716 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022732 Css NA 0.204 mg/L PBTK NA 50% Rat Human -DTXSID9022732 Css NA 0.988 mg/L PBTK NA 95% Rat Human -DTXSID9022734 Clint NA 23.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022734 Fup NA 0.1407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022734 Vd NA 3.067 L/kg 1compartment NA NA Human Human +DTXSID9022732 TK.Half.Life NA 1.652 hours 1compartment NA NA Rat Human +DTXSID9022732 Css NA 0.004169 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022732 Css NA 0.028 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022732 Css NA 0.00283 mg/L PBTK NA 50% Rat Human +DTXSID9022732 Css NA 0.01635 mg/L PBTK NA 95% Rat Human +DTXSID9022734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022734 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022734 Vd NA 2.994 L/kg 1compartment NA NA Human Human DTXSID9022734 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9022734 TK.Half.Life NA 21.2 hours 1compartment NA NA Human Human -DTXSID9022734 Css NA 0.7586 mg/L 3compartmentss NA 50% Human Human -DTXSID9022734 Css NA 4.987 mg/L 3compartmentss NA 95% Human Human -DTXSID9022734 Css NA 0.5426 mg/L PBTK NA 50% Human Human -DTXSID9022734 Css NA 3.421 mg/L PBTK NA 95% Human Human -DTXSID9022734 Clint NA 23.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022734 Fup NA 0.1407 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022734 Vd NA 2.338 L/kg 1compartment NA NA Rat Human +DTXSID9022734 TK.Half.Life NA 21.98 hours 1compartment NA NA Human Human +DTXSID9022734 Css NA 0.8248 mg/L 3compartmentss NA 50% Human Human +DTXSID9022734 Css NA 5.291 mg/L 3compartmentss NA 95% Human Human +DTXSID9022734 Css NA 0.5805 mg/L PBTK NA 50% Human Human +DTXSID9022734 Css NA 3.59 mg/L PBTK NA 95% Human Human +DTXSID9022734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022734 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022734 Vd NA 2.282 L/kg 1compartment NA NA Rat Human DTXSID9022734 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9022734 TK.Half.Life NA 3.836 hours 1compartment NA NA Rat Human -DTXSID9022734 Css NA 0.4234 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022734 Css NA 2.043 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022734 Css NA 0.2906 mg/L PBTK NA 50% Rat Human -DTXSID9022734 Css NA 1.366 mg/L PBTK NA 95% Rat Human -DTXSID9022736 Clint NA 23.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022736 Fup NA 0.4695 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022736 Vd NA 0.6038 L/kg 1compartment NA NA Human Human +DTXSID9022734 TK.Half.Life NA 4.229 hours 1compartment NA NA Rat Human +DTXSID9022734 Css NA 0.1046 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022734 Css NA 0.5619 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022734 Css NA 0.07348 mg/L PBTK NA 50% Rat Human +DTXSID9022734 Css NA 0.3903 mg/L PBTK NA 95% Rat Human +DTXSID9022736 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022736 Fup 0.733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022736 Vd NA 0.8799 L/kg 1compartment NA NA Human Human DTXSID9022736 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022736 TK.Half.Life NA 0.6134 hours 1compartment NA NA Human Human -DTXSID9022736 Css NA 0.04155 mg/L 3compartmentss NA 50% Human Human -DTXSID9022736 Css NA 0.3533 mg/L 3compartmentss NA 95% Human Human -DTXSID9022736 Css NA 0.03128 mg/L PBTK NA 50% Human Human -DTXSID9022736 Css NA 0.2392 mg/L PBTK NA 95% Human Human -DTXSID9022736 Clint NA 23.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022736 Fup NA 0.4695 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022736 Vd NA 0.6089 L/kg 1compartment NA NA Rat Human +DTXSID9022736 TK.Half.Life NA 7.87 hours 1compartment NA NA Human Human +DTXSID9022736 Css NA 0.9914 mg/L 3compartmentss NA 50% Human Human +DTXSID9022736 Css NA 6.374 mg/L 3compartmentss NA 95% Human Human +DTXSID9022736 Css NA 0.8396 mg/L PBTK NA 50% Human Human +DTXSID9022736 Css NA 4.141 mg/L PBTK NA 95% Human Human +DTXSID9022736 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022736 Fup 0.733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022736 Vd NA 0.8697 L/kg 1compartment NA NA Rat Human DTXSID9022736 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022736 TK.Half.Life NA 0.3112 hours 1compartment NA NA Rat Human -DTXSID9022736 Css NA 0.02184 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022736 Css NA 0.1531 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022736 Css NA 0.01583 mg/L PBTK NA 50% Rat Human -DTXSID9022736 Css NA 0.09643 mg/L PBTK NA 95% Rat Human +DTXSID9022736 TK.Half.Life NA 2.625 hours 1compartment NA NA Rat Human +DTXSID9022736 Css NA 0.05886 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022736 Css NA 0.3817 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022736 Css NA 0.05011 mg/L PBTK NA 50% Rat Human +DTXSID9022736 Css NA 0.2368 mg/L PBTK NA 95% Rat Human DTXSID9022738 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9022738 Fup NA 0.8768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022738 Vd NA 0.7472 L/kg 1compartment NA NA Human Human +DTXSID9022738 Vd NA 0.687 L/kg 1compartment NA NA Human Human DTXSID9022738 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022738 TK.Half.Life NA 5.519 hours 1compartment NA NA Human Human -DTXSID9022738 Css NA 0.9408 mg/L 3compartmentss NA 50% Human Human -DTXSID9022738 Css NA 5.579 mg/L 3compartmentss NA 95% Human Human -DTXSID9022738 Css NA 0.7761 mg/L PBTK NA 50% Human Human -DTXSID9022738 Css NA 3.578 mg/L PBTK NA 95% Human Human +DTXSID9022738 TK.Half.Life NA 5.071 hours 1compartment NA NA Human Human +DTXSID9022738 Css NA 0.5212 mg/L 3compartmentss NA 50% Human Human +DTXSID9022738 Css NA 3.129 mg/L 3compartmentss NA 95% Human Human +DTXSID9022738 Css NA 0.4248 mg/L PBTK NA 50% Human Human +DTXSID9022738 Css NA 2.031 mg/L PBTK NA 95% Human Human DTXSID9022738 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9022738 Fup NA 0.8768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022738 Vd NA 0.7765 L/kg 1compartment NA NA Rat Human +DTXSID9022738 Vd NA 0.727 L/kg 1compartment NA NA Rat Human DTXSID9022738 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022738 TK.Half.Life NA 1.953 hours 1compartment NA NA Rat Human -DTXSID9022738 Css NA 0.2402 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022738 Css NA 1.317 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022738 Css NA 0.1928 mg/L PBTK NA 50% Rat Human -DTXSID9022738 Css NA 0.7951 mg/L PBTK NA 95% Rat Human -DTXSID9022780 Clint NA 1.406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9022738 TK.Half.Life NA 1.828 hours 1compartment NA NA Rat Human +DTXSID9022738 Css NA 0.00268 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022738 Css NA 0.01672 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022738 Css NA 0.002133 mg/L PBTK NA 50% Rat Human +DTXSID9022738 Css NA 0.01038 mg/L PBTK NA 95% Rat Human +DTXSID9022780 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9022780 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9022780 Vd NA 1.078 L/kg 1compartment NA NA Human Human DTXSID9022780 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022780 TK.Half.Life NA 2.766 hours 1compartment NA NA Human Human -DTXSID9022780 Css NA 0.2417 mg/L 3compartmentss NA 50% Human Human -DTXSID9022780 Css NA 1.736 mg/L 3compartmentss NA 95% Human Human -DTXSID9022780 Css NA 0.2254 mg/L PBTK NA 50% Human Human -DTXSID9022780 Css NA 1.193 mg/L PBTK NA 95% Human Human -DTXSID9022780 Clint NA 1.406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9022780 TK.Half.Life NA 8.314 hours 1compartment NA NA Human Human +DTXSID9022780 Css NA 0.3749 mg/L 3compartmentss NA 50% Human Human +DTXSID9022780 Css NA 1.847 mg/L 3compartmentss NA 95% Human Human +DTXSID9022780 Css NA 0.3824 mg/L PBTK NA 50% Human Human +DTXSID9022780 Css NA 1.883 mg/L PBTK NA 95% Human Human +DTXSID9022780 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9022780 Fup 0.85 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9022780 Vd NA 1.068 L/kg 1compartment NA NA Rat Human DTXSID9022780 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022780 TK.Half.Life NA 1.371 hours 1compartment NA NA Rat Human -DTXSID9022780 Css NA 0.1023 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022780 Css NA 0.7013 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022780 Css NA 0.09494 mg/L PBTK NA 50% Rat Human -DTXSID9022780 Css NA 0.4468 mg/L PBTK NA 95% Rat Human -DTXSID9022782 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9022780 TK.Half.Life NA 2.779 hours 1compartment NA NA Rat Human +DTXSID9022780 Css NA 0.001729 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022780 Css NA 0.007822 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022780 Css NA 0.001767 mg/L PBTK NA 50% Rat Human +DTXSID9022780 Css NA 0.007999 mg/L PBTK NA 95% Rat Human +DTXSID9022782 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9022782 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9022782 Vd NA 0.4555 L/kg 1compartment NA NA Human Human +DTXSID9022782 Vd NA 0.4559 L/kg 1compartment NA NA Human Human DTXSID9022782 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022782 TK.Half.Life NA 0.582 hours 1compartment NA NA Human Human -DTXSID9022782 Css NA 0.1037 mg/L 3compartmentss NA 50% Human Human -DTXSID9022782 Css NA 0.7813 mg/L 3compartmentss NA 95% Human Human -DTXSID9022782 Css NA 0.07615 mg/L PBTK NA 50% Human Human -DTXSID9022782 Css NA 0.5132 mg/L PBTK NA 95% Human Human -DTXSID9022782 Clint NA 4.428 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9022782 TK.Half.Life NA 0.5071 hours 1compartment NA NA Human Human +DTXSID9022782 Css NA 0.0335 mg/L 3compartmentss NA 50% Human Human +DTXSID9022782 Css NA 0.3388 mg/L 3compartmentss NA 95% Human Human +DTXSID9022782 Css NA 0.02464 mg/L PBTK NA 50% Human Human +DTXSID9022782 Css NA 0.2251 mg/L PBTK NA 95% Human Human +DTXSID9022782 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9022782 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9022782 Vd NA 0.483 L/kg 1compartment NA NA Rat Human +DTXSID9022782 Vd NA 0.4832 L/kg 1compartment NA NA Rat Human DTXSID9022782 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022782 TK.Half.Life NA 0.32 hours 1compartment NA NA Rat Human -DTXSID9022782 Css NA 0.04946 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022782 Css NA 0.3332 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022782 Css NA 0.03536 mg/L PBTK NA 50% Rat Human -DTXSID9022782 Css NA 0.1998 mg/L PBTK NA 95% Rat Human +DTXSID9022782 TK.Half.Life NA 0.2736 hours 1compartment NA NA Rat Human +DTXSID9022782 Css NA 0.0002904 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022782 Css NA 0.002925 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022782 Css NA 0.0002073 mg/L PBTK NA 50% Rat Human +DTXSID9022782 Css NA 0.001842 mg/L PBTK NA 95% Rat Human +DTXSID9022784 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022784 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9022784 Vd NA 0.3703 L/kg 1compartment NA NA Human Human +DTXSID9022784 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022784 TK.Half.Life NA 4.357 hours 1compartment NA NA Human Human +DTXSID9022784 Css NA 0.7969 mg/L 3compartmentss NA 50% Human Human +DTXSID9022784 Css NA 5.048 mg/L 3compartmentss NA 95% Human Human +DTXSID9022784 Css NA 0.5632 mg/L PBTK NA 50% Human Human +DTXSID9022784 Css NA 3.022 mg/L PBTK NA 95% Human Human +DTXSID9022784 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022784 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9022784 Vd NA 0.3881 L/kg 1compartment NA NA Rat Human +DTXSID9022784 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9022784 TK.Half.Life NA 1.556 hours 1compartment NA NA Rat Human +DTXSID9022784 Css NA 0.004265 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022784 Css NA 0.02716 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022784 Css NA 0.002873 mg/L PBTK NA 50% Rat Human +DTXSID9022784 Css NA 0.01584 mg/L PBTK NA 95% Rat Human DTXSID9022786 Clint 6.1 NA uL/min/million hepatocytes NA https://doi.org/10.1016/j.etap.2016.01.017 NA Human Human DTXSID9022786 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9022786 Vd NA 1.51 L/kg 1compartment NA NA Human Human DTXSID9022786 Days.Css NA 12 Days PBTK NA NA Human Human DTXSID9022786 TK.Half.Life NA 74.18 hours 1compartment NA NA Human Human -DTXSID9022786 Css NA 8.462 mg/L 3compartmentss NA 50% Human Human -DTXSID9022786 Css NA 67.4 mg/L 3compartmentss NA 95% Human Human -DTXSID9022786 Css NA 5.262 mg/L PBTK NA 50% Human Human -DTXSID9022786 Css NA 40.5 mg/L PBTK NA 95% Human Human +DTXSID9022786 Css NA 7.302 mg/L 3compartmentss NA 50% Human Human +DTXSID9022786 Css NA 58.68 mg/L 3compartmentss NA 95% Human Human +DTXSID9022786 Css NA 4.52 mg/L PBTK NA 50% Human Human +DTXSID9022786 Css NA 35.16 mg/L PBTK NA 95% Human Human DTXSID9022786 Clint 2.292 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID9022786 Fup 0.029 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID9022786 Vd NA 1.647 L/kg 1compartment NA NA Rat Rat DTXSID9022786 Days.Css NA 13 Days PBTK NA NA Rat Rat DTXSID9022786 TK.Half.Life NA 38.06 hours 1compartment NA NA Rat Rat -DTXSID9022786 Css NA 5.108 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9022786 Css NA 21.67 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9022786 Css NA 3.165 mg/L PBTK NA 50% Rat Rat -DTXSID9022786 Css NA 12.33 mg/L PBTK NA 95% Rat Rat +DTXSID9022786 Css NA 0.3841 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9022786 Css NA 2.615 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9022786 Css NA 0.2436 mg/L PBTK NA 50% Rat Rat +DTXSID9022786 Css NA 1.563 mg/L PBTK NA 95% Rat Rat +DTXSID9022811 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022811 Fup 0.52 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9022811 Vd NA 0.4328 L/kg 1compartment NA NA Human Human +DTXSID9022811 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022811 TK.Half.Life NA 5.386 hours 1compartment NA NA Human Human +DTXSID9022811 Css NA 0.82 mg/L 3compartmentss NA 50% Human Human +DTXSID9022811 Css NA 4.515 mg/L 3compartmentss NA 95% Human Human +DTXSID9022811 Css NA 0.5872 mg/L PBTK NA 50% Human Human +DTXSID9022811 Css NA 2.839 mg/L PBTK NA 95% Human Human +DTXSID9022811 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022811 Fup 0.52 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9022811 Vd NA 0.4474 L/kg 1compartment NA NA Rat Human +DTXSID9022811 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9022811 TK.Half.Life NA 1.898 hours 1compartment NA NA Rat Human +DTXSID9022811 Css NA 0.004419 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022811 Css NA 0.02512 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022811 Css NA 0.003008 mg/L PBTK NA 50% Rat Human +DTXSID9022811 Css NA 0.01493 mg/L PBTK NA 95% Rat Human DTXSID9022813 Clint 10.96 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID9022813 Fup NA 0.1393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022813 Vd NA 0.5473 L/kg 1compartment NA NA Human Human +DTXSID9022813 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022813 Vd NA 0.6818 L/kg 1compartment NA NA Human Human DTXSID9022813 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022813 TK.Half.Life NA 1.745 hours 1compartment NA NA Human Human -DTXSID9022813 Css NA 0.3722 mg/L 3compartmentss NA 50% Human Human -DTXSID9022813 Css NA 2.873 mg/L 3compartmentss NA 95% Human Human -DTXSID9022813 Css NA 0.2398 mg/L PBTK NA 50% Human Human -DTXSID9022813 Css NA 1.754 mg/L PBTK NA 95% Human Human +DTXSID9022813 TK.Half.Life NA 1.923 hours 1compartment NA NA Human Human +DTXSID9022813 Css NA 0.2764 mg/L 3compartmentss NA 50% Human Human +DTXSID9022813 Css NA 1.947 mg/L 3compartmentss NA 95% Human Human +DTXSID9022813 Css NA 0.1839 mg/L PBTK NA 50% Human Human +DTXSID9022813 Css NA 1.217 mg/L PBTK NA 95% Human Human DTXSID9022813 Clint 10.96 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID9022813 Fup NA 0.1393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022813 Vd NA 0.4822 L/kg 1compartment NA NA Rat Human +DTXSID9022813 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022813 Vd NA 0.5854 L/kg 1compartment NA NA Rat Human DTXSID9022813 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022813 TK.Half.Life NA 0.909 hours 1compartment NA NA Rat Human -DTXSID9022813 Css NA 0.2068 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022813 Css NA 1.117 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022813 Css NA 0.1254 mg/L PBTK NA 50% Rat Human -DTXSID9022813 Css NA 0.639 mg/L PBTK NA 95% Rat Human +DTXSID9022813 TK.Half.Life NA 0.9559 hours 1compartment NA NA Rat Human +DTXSID9022813 Css NA 0.03457 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022813 Css NA 0.1758 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022813 Css NA 0.02256 mg/L PBTK NA 50% Rat Human +DTXSID9022813 Css NA 0.1086 mg/L PBTK NA 95% Rat Human DTXSID9022815 Clint NA 250.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9022815 Fup NA 0.0538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022815 Vd NA 0.2194 L/kg 1compartment NA NA Human Human +DTXSID9022815 Vd NA 0.1821 L/kg 1compartment NA NA Human Human DTXSID9022815 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022815 TK.Half.Life NA 0.2648 hours 1compartment NA NA Human Human -DTXSID9022815 Css NA 0.04764 mg/L 3compartmentss NA 50% Human Human -DTXSID9022815 Css NA 0.4315 mg/L 3compartmentss NA 95% Human Human -DTXSID9022815 Css NA 0.02849 mg/L PBTK NA 50% Human Human -DTXSID9022815 Css NA 0.2506 mg/L PBTK NA 95% Human Human +DTXSID9022815 TK.Half.Life NA 0.2175 hours 1compartment NA NA Human Human +DTXSID9022815 Css NA 0.03125 mg/L 3compartmentss NA 50% Human Human +DTXSID9022815 Css NA 0.3239 mg/L 3compartmentss NA 95% Human Human +DTXSID9022815 Css NA 0.01833 mg/L PBTK NA 50% Human Human +DTXSID9022815 Css NA 0.1897 mg/L PBTK NA 95% Human Human DTXSID9022815 Clint NA 250.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9022815 Fup NA 0.0538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022815 Vd NA 0.2216 L/kg 1compartment NA NA Rat Human +DTXSID9022815 Vd NA 0.1837 L/kg 1compartment NA NA Rat Human DTXSID9022815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022815 TK.Half.Life NA 0.1316 hours 1compartment NA NA Rat Human -DTXSID9022815 Css NA 0.0279 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022815 Css NA 0.2048 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022815 Css NA 0.01554 mg/L PBTK NA 50% Rat Human -DTXSID9022815 Css NA 0.1123 mg/L PBTK NA 95% Rat Human +DTXSID9022815 TK.Half.Life NA 0.1068 hours 1compartment NA NA Rat Human +DTXSID9022815 Css NA 0.001197 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022815 Css NA 0.01395 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022815 Css NA 0.0006695 mg/L PBTK NA 50% Rat Human +DTXSID9022815 Css NA 0.007817 mg/L PBTK NA 95% Rat Human DTXSID9022817 Clint 88.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9022817 Fup 3.85e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9022817 Vd NA 0.1593 L/kg 1compartment NA NA Human Human +DTXSID9022817 Vd NA 0.1592 L/kg 1compartment NA NA Human Human DTXSID9022817 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID9022817 TK.Half.Life NA 69.25 hours 1compartment NA NA Human Human -DTXSID9022817 Css NA 21.2 mg/L 3compartmentss NA 50% Human Human -DTXSID9022817 Css NA 437.9 mg/L 3compartmentss NA 95% Human Human -DTXSID9022817 Css NA 12.31 mg/L PBTK NA 50% Human Human -DTXSID9022817 Css NA 253.7 mg/L PBTK NA 95% Human Human +DTXSID9022817 TK.Half.Life NA 69.58 hours 1compartment NA NA Human Human +DTXSID9022817 Css NA 6.142 mg/L 3compartmentss NA 50% Human Human +DTXSID9022817 Css NA 148.9 mg/L 3compartmentss NA 95% Human Human +DTXSID9022817 Css NA 3.584 mg/L PBTK NA 50% Human Human +DTXSID9022817 Css NA 85.88 mg/L PBTK NA 95% Human Human DTXSID9022817 Clint 88.8 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9022817 Fup 3.85e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9022817 Vd NA 0.1578 L/kg 1compartment NA NA Rat Human DTXSID9022817 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID9022817 TK.Half.Life NA 47.8 hours 1compartment NA NA Rat Human -DTXSID9022817 Css NA 13.11 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022817 Css NA 204.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022817 Css NA 7.082 mg/L PBTK NA 50% Rat Human -DTXSID9022817 Css NA 110.7 mg/L PBTK NA 95% Rat Human -DTXSID9022861 Clint NA 0.3782 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022861 Fup NA 0.8119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022861 Vd NA 1.532 L/kg 1compartment NA NA Human Human +DTXSID9022817 TK.Half.Life NA 48.07 hours 1compartment NA NA Rat Human +DTXSID9022817 Css NA 0.06268 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022817 Css NA 1.052 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022817 Css NA 0.03391 mg/L PBTK NA 50% Rat Human +DTXSID9022817 Css NA 0.569 mg/L PBTK NA 95% Rat Human +DTXSID9022819 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022819 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9022819 Vd NA 6.769 L/kg 1compartment NA NA Human Human +DTXSID9022819 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022819 TK.Half.Life NA 2.946 hours 1compartment NA NA Human Human +DTXSID9022819 Css NA 0.008052 mg/L 3compartmentss NA 50% Human Human +DTXSID9022819 Css NA 0.1152 mg/L 3compartmentss NA 95% Human Human +DTXSID9022819 Css NA 0.01707 mg/L PBTK NA 50% Human Human +DTXSID9022819 Css NA 0.1477 mg/L PBTK NA 95% Human Human +DTXSID9022819 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022819 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9022819 Vd NA 6.836 L/kg 1compartment NA NA Rat Human +DTXSID9022819 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9022819 TK.Half.Life NA 1.584 hours 1compartment NA NA Rat Human +DTXSID9022819 Css NA 0.0009634 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022819 Css NA 0.01125 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022819 Css NA 0.002195 mg/L PBTK NA 50% Rat Human +DTXSID9022819 Css NA 0.01463 mg/L PBTK NA 95% Rat Human +DTXSID9022861 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022861 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022861 Vd NA 0.5769 L/kg 1compartment NA NA Human Human DTXSID9022861 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022861 TK.Half.Life NA 8.175 hours 1compartment NA NA Human Human -DTXSID9022861 Css NA 0.5412 mg/L 3compartmentss NA 50% Human Human -DTXSID9022861 Css NA 3.608 mg/L 3compartmentss NA 95% Human Human -DTXSID9022861 Css NA 0.5029 mg/L PBTK NA 50% Human Human -DTXSID9022861 Css NA 2.404 mg/L PBTK NA 95% Human Human -DTXSID9022861 Clint NA 0.3782 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022861 Fup NA 0.8119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022861 Vd NA 1.439 L/kg 1compartment NA NA Rat Human +DTXSID9022861 TK.Half.Life NA 7.156 hours 1compartment NA NA Human Human +DTXSID9022861 Css NA 0.7651 mg/L 3compartmentss NA 50% Human Human +DTXSID9022861 Css NA 4.616 mg/L 3compartmentss NA 95% Human Human +DTXSID9022861 Css NA 0.5808 mg/L PBTK NA 50% Human Human +DTXSID9022861 Css NA 2.903 mg/L PBTK NA 95% Human Human +DTXSID9022861 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022861 Fup 0.526 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022861 Vd NA 0.561 L/kg 1compartment NA NA Rat Human DTXSID9022861 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022861 TK.Half.Life NA 3.059 hours 1compartment NA NA Rat Human -DTXSID9022861 Css NA 0.1762 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022861 Css NA 1.121 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022861 Css NA 0.1598 mg/L PBTK NA 50% Rat Human -DTXSID9022861 Css NA 0.6993 mg/L PBTK NA 95% Rat Human +DTXSID9022861 TK.Half.Life NA 2.357 hours 1compartment NA NA Rat Human +DTXSID9022861 Css NA 0.004062 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022861 Css NA 0.02447 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022861 Css NA 0.002961 mg/L PBTK NA 50% Rat Human +DTXSID9022861 Css NA 0.01476 mg/L PBTK NA 95% Rat Human DTXSID9022940 Clint 13.63 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID9022940 Fup 0.198 NA NA https://doi.org/10.1023/B:PHAM.0000026429.12114.7d NA Human Human DTXSID9022940 Vd NA 1.965 L/kg 1compartment NA NA Human Human DTXSID9022940 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9022940 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human -DTXSID9022940 Css NA 0.1966 mg/L 3compartmentss NA 50% Human Human -DTXSID9022940 Css NA 1.239 mg/L 3compartmentss NA 95% Human Human -DTXSID9022940 Css NA 0.157 mg/L PBTK NA 50% Human Human -DTXSID9022940 Css NA 0.9246 mg/L PBTK NA 95% Human Human +DTXSID9022940 Css NA 0.1775 mg/L 3compartmentss NA 50% Human Human +DTXSID9022940 Css NA 1.087 mg/L 3compartmentss NA 95% Human Human +DTXSID9022940 Css NA 0.1736 mg/L PBTK NA 50% Human Human +DTXSID9022940 Css NA 1.064 mg/L PBTK NA 95% Human Human DTXSID9022940 Clint 682.7 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID9022940 Fup 0.18 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID9022940 Vd NA 1.463 L/kg 1compartment NA NA Rat Rat DTXSID9022940 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9022940 TK.Half.Life NA 0.4085 hours 1compartment NA NA Rat Rat -DTXSID9022940 Css NA 0.002739 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9022940 Css NA 0.01677 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9022940 Css NA 0.002144 mg/L PBTK NA 50% Rat Rat -DTXSID9022940 Css NA 0.01203 mg/L PBTK NA 95% Rat Rat -DTXSID9022944 Clint NA 40.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022944 Fup NA 0.5991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022944 Vd NA 9.054 L/kg 1compartment NA NA Human Human -DTXSID9022944 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9022944 TK.Half.Life NA 29.57 hours 1compartment NA NA Human Human -DTXSID9022944 Css NA 0.2096 mg/L 3compartmentss NA 50% Human Human -DTXSID9022944 Css NA 1.482 mg/L 3compartmentss NA 95% Human Human -DTXSID9022944 Css NA 0.2388 mg/L PBTK NA 50% Human Human -DTXSID9022944 Css NA 1.486 mg/L PBTK NA 95% Human Human -DTXSID9022944 Clint NA 40.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022944 Fup NA 0.5991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022944 Vd NA 7.119 L/kg 1compartment NA NA Rat Human -DTXSID9022944 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9022944 TK.Half.Life NA 4.857 hours 1compartment NA NA Rat Human -DTXSID9022944 Css NA 0.1156 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022944 Css NA 0.6519 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022944 Css NA 0.1296 mg/L PBTK NA 50% Rat Human -DTXSID9022944 Css NA 0.6652 mg/L PBTK NA 95% Rat Human -DTXSID9022946 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022946 Fup NA 0.0874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022946 Vd NA 0.6936 L/kg 1compartment NA NA Human Human -DTXSID9022946 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID9022946 TK.Half.Life NA 52.43 hours 1compartment NA NA Human Human -DTXSID9022946 Css NA 10.31 mg/L 3compartmentss NA 50% Human Human -DTXSID9022946 Css NA 50.83 mg/L 3compartmentss NA 95% Human Human -DTXSID9022946 Css NA 7.324 mg/L PBTK NA 50% Human Human -DTXSID9022946 Css NA 31.5 mg/L PBTK NA 95% Human Human -DTXSID9022946 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022946 Fup NA 0.0874 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022946 Vd NA 0.6416 L/kg 1compartment NA NA Rat Human -DTXSID9022946 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9022946 TK.Half.Life NA 16.27 hours 1compartment NA NA Rat Human -DTXSID9022946 Css NA 2.931 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022946 Css NA 12.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022946 Css NA 1.964 mg/L PBTK NA 50% Rat Human -DTXSID9022946 Css NA 6.994 mg/L PBTK NA 95% Rat Human -DTXSID9022994 Clint NA 83.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022994 Fup NA 0.284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022994 Vd NA 2.536 L/kg 1compartment NA NA Human Human -DTXSID9022994 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9022994 TK.Half.Life NA 2.819 hours 1compartment NA NA Human Human -DTXSID9022994 Css NA 0.04474 mg/L 3compartmentss NA 50% Human Human -DTXSID9022994 Css NA 0.2914 mg/L 3compartmentss NA 95% Human Human -DTXSID9022994 Css NA 0.03334 mg/L PBTK NA 50% Human Human -DTXSID9022994 Css NA 0.2087 mg/L PBTK NA 95% Human Human -DTXSID9022994 Clint NA 83.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022994 Fup NA 0.284 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022994 Vd NA 1.948 L/kg 1compartment NA NA Rat Human -DTXSID9022994 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9022994 TK.Half.Life NA 0.8672 hours 1compartment NA NA Rat Human -DTXSID9022994 Css NA 0.02454 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022994 Css NA 0.1352 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022994 Css NA 0.01766 mg/L PBTK NA 50% Rat Human -DTXSID9022994 Css NA 0.09353 mg/L PBTK NA 95% Rat Human -DTXSID9022998 Clint NA 74.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022998 Fup NA 0.0088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9022998 Vd NA 5.034 L/kg 1compartment NA NA Human Human -DTXSID9022998 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID9022998 TK.Half.Life NA 46.93 hours 1compartment NA NA Human Human -DTXSID9022998 Css NA 0.8858 mg/L 3compartmentss NA 50% Human Human -DTXSID9022998 Css NA 5.497 mg/L 3compartmentss NA 95% Human Human -DTXSID9022998 Css NA 0.7199 mg/L PBTK NA 50% Human Human -DTXSID9022998 Css NA 4.274 mg/L PBTK NA 95% Human Human -DTXSID9022998 Clint NA 74.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022998 Fup NA 0.0088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9022998 Vd NA 3.845 L/kg 1compartment NA NA Rat Human -DTXSID9022998 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9022998 TK.Half.Life NA 7.011 hours 1compartment NA NA Rat Human -DTXSID9022998 Css NA 0.5012 mg/L 3compartmentss NA 50% Rat Human -DTXSID9022998 Css NA 2.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID9022998 Css NA 0.3939 mg/L PBTK NA 50% Rat Human -DTXSID9022998 Css NA 1.798 mg/L PBTK NA 95% Rat Human -DTXSID9023041 Clint NA 16.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023041 Fup NA 0.4399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023041 Vd NA 0.6244 L/kg 1compartment NA NA Human Human +DTXSID9022940 Css NA 0.0003808 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9022940 Css NA 0.002736 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9022940 Css NA 0.0003908 mg/L PBTK NA 50% Rat Rat +DTXSID9022940 Css NA 0.002783 mg/L PBTK NA 95% Rat Rat +DTXSID9022944 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022944 Fup 0.0467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022944 Vd NA 0.9006 L/kg 1compartment NA NA Human Human +DTXSID9022944 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022944 TK.Half.Life NA 3.798 hours 1compartment NA NA Human Human +DTXSID9022944 Css NA 0.2955 mg/L 3compartmentss NA 50% Human Human +DTXSID9022944 Css NA 2.725 mg/L 3compartmentss NA 95% Human Human +DTXSID9022944 Css NA 0.1917 mg/L PBTK NA 50% Human Human +DTXSID9022944 Css NA 1.687 mg/L PBTK NA 95% Human Human +DTXSID9022944 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022944 Fup 0.0467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022944 Vd NA 0.8658 L/kg 1compartment NA NA Rat Human +DTXSID9022944 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9022944 TK.Half.Life NA 2.289 hours 1compartment NA NA Rat Human +DTXSID9022944 Css NA 0.003226 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022944 Css NA 0.02612 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022944 Css NA 0.00196 mg/L PBTK NA 50% Rat Human +DTXSID9022944 Css NA 0.01515 mg/L PBTK NA 95% Rat Human +DTXSID9022946 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022946 Fup 0.074 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022946 Vd NA 0.636 L/kg 1compartment NA NA Human Human +DTXSID9022946 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9022946 TK.Half.Life NA 1.956 hours 1compartment NA NA Human Human +DTXSID9022946 Css NA 0.3309 mg/L 3compartmentss NA 50% Human Human +DTXSID9022946 Css NA 2.743 mg/L 3compartmentss NA 95% Human Human +DTXSID9022946 Css NA 0.2282 mg/L PBTK NA 50% Human Human +DTXSID9022946 Css NA 1.743 mg/L PBTK NA 95% Human Human +DTXSID9022946 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022946 Fup 0.074 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022946 Vd NA 0.587 L/kg 1compartment NA NA Rat Human +DTXSID9022946 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9022946 TK.Half.Life NA 1.101 hours 1compartment NA NA Rat Human +DTXSID9022946 Css NA 0.02468 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022946 Css NA 0.198 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022946 Css NA 0.01682 mg/L PBTK NA 50% Rat Human +DTXSID9022946 Css NA 0.123 mg/L PBTK NA 95% Rat Human +DTXSID9022994 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022994 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022994 Vd NA 2.599 L/kg 1compartment NA NA Human Human +DTXSID9022994 Days.Css NA 32 Days PBTK NA NA Human Human +DTXSID9022994 TK.Half.Life NA 164.2 hours 1compartment NA NA Human Human +DTXSID9022994 Css NA 6.63 mg/L 3compartmentss NA 50% Human Human +DTXSID9022994 Css NA 20.45 mg/L 3compartmentss NA 95% Human Human +DTXSID9022994 Css NA 5.018 mg/L PBTK NA 50% Human Human +DTXSID9022994 Css NA 13.72 mg/L PBTK NA 95% Human Human +DTXSID9022994 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022994 Fup 0.317 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022994 Vd NA 1.999 L/kg 1compartment NA NA Rat Human +DTXSID9022994 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID9022994 TK.Half.Life NA 20.86 hours 1compartment NA NA Rat Human +DTXSID9022994 Css NA 0.4167 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022994 Css NA 1.034 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022994 Css NA 0.3144 mg/L PBTK NA 50% Rat Human +DTXSID9022994 Css NA 0.6724 mg/L PBTK NA 95% Rat Human +DTXSID9022998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022998 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9022998 Vd NA 3.039 L/kg 1compartment NA NA Human Human +DTXSID9022998 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID9022998 TK.Half.Life NA 76.66 hours 1compartment NA NA Human Human +DTXSID9022998 Css NA 3.092 mg/L 3compartmentss NA 50% Human Human +DTXSID9022998 Css NA 20.9 mg/L 3compartmentss NA 95% Human Human +DTXSID9022998 Css NA 2.121 mg/L PBTK NA 50% Human Human +DTXSID9022998 Css NA 14.16 mg/L PBTK NA 95% Human Human +DTXSID9022998 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022998 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9022998 Vd NA 2.275 L/kg 1compartment NA NA Rat Human +DTXSID9022998 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID9022998 TK.Half.Life NA 11.52 hours 1compartment NA NA Rat Human +DTXSID9022998 Css NA 0.4036 mg/L 3compartmentss NA 50% Rat Human +DTXSID9022998 Css NA 2.326 mg/L 3compartmentss NA 95% Rat Human +DTXSID9022998 Css NA 0.2739 mg/L PBTK NA 50% Rat Human +DTXSID9022998 Css NA 1.58 mg/L PBTK NA 95% Rat Human +DTXSID9023041 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023041 Fup 0.57 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023041 Vd NA 0.5982 L/kg 1compartment NA NA Human Human DTXSID9023041 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023041 TK.Half.Life NA 0.7477 hours 1compartment NA NA Human Human -DTXSID9023041 Css NA 0.06426 mg/L 3compartmentss NA 50% Human Human -DTXSID9023041 Css NA 0.4704 mg/L 3compartmentss NA 95% Human Human -DTXSID9023041 Css NA 0.04754 mg/L PBTK NA 50% Human Human -DTXSID9023041 Css NA 0.313 mg/L PBTK NA 95% Human Human -DTXSID9023041 Clint NA 16.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023041 Fup NA 0.4399 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023041 Vd NA 0.6 L/kg 1compartment NA NA Rat Human +DTXSID9023041 TK.Half.Life NA 0.5752 hours 1compartment NA NA Human Human +DTXSID9023041 Css NA 0.03649 mg/L 3compartmentss NA 50% Human Human +DTXSID9023041 Css NA 0.3996 mg/L 3compartmentss NA 95% Human Human +DTXSID9023041 Css NA 0.02734 mg/L PBTK NA 50% Human Human +DTXSID9023041 Css NA 0.2574 mg/L PBTK NA 95% Human Human +DTXSID9023041 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023041 Fup 0.57 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023041 Vd NA 0.5991 L/kg 1compartment NA NA Rat Human DTXSID9023041 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023041 TK.Half.Life NA 0.3737 hours 1compartment NA NA Rat Human -DTXSID9023041 Css NA 0.03291 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023041 Css NA 0.2035 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023041 Css NA 0.0234 mg/L PBTK NA 50% Rat Human -DTXSID9023041 Css NA 0.1285 mg/L PBTK NA 95% Rat Human -DTXSID9023043 Clint NA 4.881 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023043 Fup NA 0.0185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023043 Vd NA 0.2309 L/kg 1compartment NA NA Human Human +DTXSID9023041 TK.Half.Life NA 0.2856 hours 1compartment NA NA Rat Human +DTXSID9023041 Css NA 0.004386 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023041 Css NA 0.04151 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023041 Css NA 0.003324 mg/L PBTK NA 50% Rat Human +DTXSID9023041 Css NA 0.02672 mg/L PBTK NA 95% Rat Human +DTXSID9023043 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023043 Fup 0.0289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023043 Vd NA 0.2643 L/kg 1compartment NA NA Human Human DTXSID9023043 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023043 TK.Half.Life NA 9.042 hours 1compartment NA NA Human Human -DTXSID9023043 Css NA 7.167 mg/L 3compartmentss NA 50% Human Human -DTXSID9023043 Css NA 59.34 mg/L 3compartmentss NA 95% Human Human -DTXSID9023043 Css NA 4.296 mg/L PBTK NA 50% Human Human -DTXSID9023043 Css NA 34.65 mg/L PBTK NA 95% Human Human -DTXSID9023043 Clint NA 4.881 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023043 Fup NA 0.0185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023043 Vd NA 0.2239 L/kg 1compartment NA NA Rat Human +DTXSID9023043 TK.Half.Life NA 5.403 hours 1compartment NA NA Human Human +DTXSID9023043 Css NA 3.582 mg/L 3compartmentss NA 50% Human Human +DTXSID9023043 Css NA 30.36 mg/L 3compartmentss NA 95% Human Human +DTXSID9023043 Css NA 2.176 mg/L PBTK NA 50% Human Human +DTXSID9023043 Css NA 17.58 mg/L PBTK NA 95% Human Human +DTXSID9023043 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023043 Fup 0.0289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023043 Vd NA 0.256 L/kg 1compartment NA NA Rat Human DTXSID9023043 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023043 TK.Half.Life NA 5.466 hours 1compartment NA NA Rat Human -DTXSID9023043 Css NA 3.708 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023043 Css NA 24.64 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023043 Css NA 2.06 mg/L PBTK NA 50% Rat Human -DTXSID9023043 Css NA 13.39 mg/L PBTK NA 95% Rat Human +DTXSID9023043 TK.Half.Life NA 3.305 hours 1compartment NA NA Rat Human +DTXSID9023043 Css NA 0.4352 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023043 Css NA 2.938 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023043 Css NA 0.254 mg/L PBTK NA 50% Rat Human +DTXSID9023043 Css NA 1.677 mg/L PBTK NA 95% Rat Human DTXSID9023045 Clint 11.29 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID9023045 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9023045 Vd NA 0.2745 L/kg 1compartment NA NA Human Human +DTXSID9023045 Vd NA 0.261 L/kg 1compartment NA NA Human Human DTXSID9023045 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023045 TK.Half.Life NA 4.655 hours 1compartment NA NA Human Human -DTXSID9023045 Css NA 3.149 mg/L 3compartmentss NA 50% Human Human -DTXSID9023045 Css NA 28.26 mg/L 3compartmentss NA 95% Human Human -DTXSID9023045 Css NA 1.804 mg/L PBTK NA 50% Human Human -DTXSID9023045 Css NA 16.04 mg/L PBTK NA 95% Human Human +DTXSID9023045 TK.Half.Life NA 4.446 hours 1compartment NA NA Human Human +DTXSID9023045 Css NA 3.15 mg/L 3compartmentss NA 50% Human Human +DTXSID9023045 Css NA 27.84 mg/L 3compartmentss NA 95% Human Human +DTXSID9023045 Css NA 1.732 mg/L PBTK NA 50% Human Human +DTXSID9023045 Css NA 15.31 mg/L PBTK NA 95% Human Human DTXSID9023045 Clint 11.29 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID9023045 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9023045 Vd NA 0.256 L/kg 1compartment NA NA Rat Human +DTXSID9023045 Vd NA 0.2456 L/kg 1compartment NA NA Rat Human DTXSID9023045 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023045 TK.Half.Life NA 2.828 hours 1compartment NA NA Rat Human -DTXSID9023045 Css NA 1.751 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023045 Css NA 11.84 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023045 Css NA 0.9322 mg/L PBTK NA 50% Rat Human -DTXSID9023045 Css NA 6.375 mg/L PBTK NA 95% Rat Human -DTXSID9023049 Clint NA 14.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9023045 TK.Half.Life NA 2.725 hours 1compartment NA NA Rat Human +DTXSID9023045 Css NA 0.3258 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023045 Css NA 2.437 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023045 Css NA 0.185 mg/L PBTK NA 50% Rat Human +DTXSID9023045 Css NA 1.388 mg/L PBTK NA 95% Rat Human +DTXSID9023049 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9023049 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9023049 Vd NA 3.115 L/kg 1compartment NA NA Human Human -DTXSID9023049 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9023049 TK.Half.Life NA 26.42 hours 1compartment NA NA Human Human -DTXSID9023049 Css NA 1.127 mg/L 3compartmentss NA 50% Human Human -DTXSID9023049 Css NA 6.777 mg/L 3compartmentss NA 95% Human Human -DTXSID9023049 Css NA 0.7 mg/L PBTK NA 50% Human Human -DTXSID9023049 Css NA 4.142 mg/L PBTK NA 95% Human Human -DTXSID9023049 Clint NA 14.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9023049 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9023049 TK.Half.Life NA 18.73 hours 1compartment NA NA Human Human +DTXSID9023049 Css NA 0.479 mg/L 3compartmentss NA 50% Human Human +DTXSID9023049 Css NA 2.95 mg/L 3compartmentss NA 95% Human Human +DTXSID9023049 Css NA 0.4645 mg/L PBTK NA 50% Human Human +DTXSID9023049 Css NA 2.861 mg/L PBTK NA 95% Human Human +DTXSID9023049 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9023049 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9023049 Vd NA 2.388 L/kg 1compartment NA NA Rat Human DTXSID9023049 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9023049 TK.Half.Life NA 4.797 hours 1compartment NA NA Rat Human -DTXSID9023049 Css NA 0.6381 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023049 Css NA 2.99 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023049 Css NA 0.3745 mg/L PBTK NA 50% Rat Human -DTXSID9023049 Css NA 1.747 mg/L PBTK NA 95% Rat Human -DTXSID9023095 Clint NA 3.421 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9023049 TK.Half.Life NA 3.506 hours 1compartment NA NA Rat Human +DTXSID9023049 Css NA 0.0601 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023049 Css NA 0.304 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023049 Css NA 0.06038 mg/L PBTK NA 50% Rat Human +DTXSID9023049 Css NA 0.3055 mg/L PBTK NA 95% Rat Human +DTXSID9023095 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9023095 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9023095 Vd NA 0.21 L/kg 1compartment NA NA Human Human +DTXSID9023095 Vd NA 0.2234 L/kg 1compartment NA NA Human Human DTXSID9023095 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023095 TK.Half.Life NA 6.948 hours 1compartment NA NA Human Human -DTXSID9023095 Css NA 5.967 mg/L 3compartmentss NA 50% Human Human -DTXSID9023095 Css NA 44.87 mg/L 3compartmentss NA 95% Human Human -DTXSID9023095 Css NA 3.562 mg/L PBTK NA 50% Human Human -DTXSID9023095 Css NA 26.17 mg/L PBTK NA 95% Human Human -DTXSID9023095 Clint NA 3.421 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9023095 TK.Half.Life NA 1.508 hours 1compartment NA NA Human Human +DTXSID9023095 Css NA 1.086 mg/L 3compartmentss NA 50% Human Human +DTXSID9023095 Css NA 10.3 mg/L 3compartmentss NA 95% Human Human +DTXSID9023095 Css NA 0.6456 mg/L PBTK NA 50% Human Human +DTXSID9023095 Css NA 6.141 mg/L PBTK NA 95% Human Human +DTXSID9023095 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9023095 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9023095 Vd NA 0.2063 L/kg 1compartment NA NA Rat Human +DTXSID9023095 Vd NA 0.2181 L/kg 1compartment NA NA Rat Human DTXSID9023095 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023095 TK.Half.Life NA 4.094 hours 1compartment NA NA Rat Human -DTXSID9023095 Css NA 3.037 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023095 Css NA 18.28 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023095 Css NA 1.68 mg/L PBTK NA 50% Rat Human -DTXSID9023095 Css NA 9.926 mg/L PBTK NA 95% Rat Human -DTXSID9023097 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023097 Fup NA 0.0872 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023097 Vd NA 0.3517 L/kg 1compartment NA NA Human Human -DTXSID9023097 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9023097 TK.Half.Life NA 26.24 hours 1compartment NA NA Human Human -DTXSID9023097 Css NA 11.74 mg/L 3compartmentss NA 50% Human Human -DTXSID9023097 Css NA 53.16 mg/L 3compartmentss NA 95% Human Human -DTXSID9023097 Css NA 7.236 mg/L PBTK NA 50% Human Human -DTXSID9023097 Css NA 31.4 mg/L PBTK NA 95% Human Human -DTXSID9023097 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023097 Fup NA 0.0872 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023097 Vd NA 0.3281 L/kg 1compartment NA NA Rat Human +DTXSID9023095 TK.Half.Life NA 0.9513 hours 1compartment NA NA Rat Human +DTXSID9023095 Css NA 0.1438 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023095 Css NA 1.098 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023095 Css NA 0.08268 mg/L PBTK NA 50% Rat Human +DTXSID9023095 Css NA 0.6192 mg/L PBTK NA 95% Rat Human +DTXSID9023097 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023097 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023097 Vd NA 0.4408 L/kg 1compartment NA NA Human Human +DTXSID9023097 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023097 TK.Half.Life NA 1.296 hours 1compartment NA NA Human Human +DTXSID9023097 Css NA 0.1426 mg/L 3compartmentss NA 50% Human Human +DTXSID9023097 Css NA 1.011 mg/L 3compartmentss NA 95% Human Human +DTXSID9023097 Css NA 0.09838 mg/L PBTK NA 50% Human Human +DTXSID9023097 Css NA 0.6463 mg/L PBTK NA 95% Human Human +DTXSID9023097 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023097 Fup 0.246 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023097 Vd NA 0.4454 L/kg 1compartment NA NA Rat Human DTXSID9023097 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023097 TK.Half.Life NA 8.306 hours 1compartment NA NA Rat Human -DTXSID9023097 Css NA 3.374 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023097 Css NA 12.65 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023097 Css NA 1.94 mg/L PBTK NA 50% Rat Human -DTXSID9023097 Css NA 6.958 mg/L PBTK NA 95% Rat Human +DTXSID9023097 TK.Half.Life NA 0.7599 hours 1compartment NA NA Rat Human +DTXSID9023097 Css NA 0.001389 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023097 Css NA 0.007842 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023097 Css NA 0.000913 mg/L PBTK NA 50% Rat Human +DTXSID9023097 Css NA 0.004758 mg/L PBTK NA 95% Rat Human DTXSID9023122 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID9023122 Fup 0.53 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID9023122 Vd NA 1.426 L/kg 1compartment NA NA Human Human DTXSID9023122 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID9023122 TK.Half.Life NA 22.64 hours 1compartment NA NA Human Human -DTXSID9023122 Css NA 1.54 mg/L 3compartmentss NA 50% Human Human -DTXSID9023122 Css NA 8.416 mg/L 3compartmentss NA 95% Human Human -DTXSID9023122 Css NA 1.371 mg/L PBTK NA 50% Human Human -DTXSID9023122 Css NA 5.699 mg/L PBTK NA 95% Human Human +DTXSID9023122 Css NA 1.322 mg/L 3compartmentss NA 50% Human Human +DTXSID9023122 Css NA 5.318 mg/L 3compartmentss NA 95% Human Human +DTXSID9023122 Css NA 1.322 mg/L PBTK NA 50% Human Human +DTXSID9023122 Css NA 5.318 mg/L PBTK NA 95% Human Human DTXSID9023122 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID9023122 Fup 0.53 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human DTXSID9023122 Vd NA 1.273 L/kg 1compartment NA NA Rat Human DTXSID9023122 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9023122 TK.Half.Life NA 4.39 hours 1compartment NA NA Rat Human -DTXSID9023122 Css NA 0.3516 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023122 Css NA 1.938 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023122 Css NA 0.294 mg/L PBTK NA 50% Rat Human -DTXSID9023122 Css NA 1.189 mg/L PBTK NA 95% Rat Human -DTXSID9023128 Clint NA 15.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023128 Fup NA 0.0905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023128 Vd NA 1.325 L/kg 1compartment NA NA Human Human +DTXSID9023122 Css NA 0.06566 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023122 Css NA 0.2666 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023122 Css NA 0.068 mg/L PBTK NA 50% Rat Human +DTXSID9023122 Css NA 0.2761 mg/L PBTK NA 95% Rat Human +DTXSID9023128 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023128 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023128 Vd NA 1.29 L/kg 1compartment NA NA Human Human DTXSID9023128 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023128 TK.Half.Life NA 4.037 hours 1compartment NA NA Human Human -DTXSID9023128 Css NA 0.3508 mg/L 3compartmentss NA 50% Human Human -DTXSID9023128 Css NA 2.942 mg/L 3compartmentss NA 95% Human Human -DTXSID9023128 Css NA 0.2524 mg/L PBTK NA 50% Human Human -DTXSID9023128 Css NA 1.892 mg/L PBTK NA 95% Human Human -DTXSID9023128 Clint NA 15.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023128 Fup NA 0.0905 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023128 Vd NA 1.313 L/kg 1compartment NA NA Rat Human +DTXSID9023128 TK.Half.Life NA 3.621 hours 1compartment NA NA Human Human +DTXSID9023128 Css NA 0.2497 mg/L 3compartmentss NA 50% Human Human +DTXSID9023128 Css NA 1.553 mg/L 3compartmentss NA 95% Human Human +DTXSID9023128 Css NA 0.1841 mg/L PBTK NA 50% Human Human +DTXSID9023128 Css NA 1.058 mg/L PBTK NA 95% Human Human +DTXSID9023128 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023128 Fup 0.298 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023128 Vd NA 1.04 L/kg 1compartment NA NA Rat Human DTXSID9023128 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023128 TK.Half.Life NA 2.459 hours 1compartment NA NA Rat Human -DTXSID9023128 Css NA 0.1921 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023128 Css NA 1.276 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023128 Css NA 0.1314 mg/L PBTK NA 50% Rat Human -DTXSID9023128 Css NA 0.7649 mg/L PBTK NA 95% Rat Human -DTXSID9023170 Clint NA 89.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023170 Fup NA 0.1498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023170 Vd NA 1.858 L/kg 1compartment NA NA Human Human +DTXSID9023128 TK.Half.Life NA 1.505 hours 1compartment NA NA Rat Human +DTXSID9023128 Css NA 0.02944 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023128 Css NA 0.1285 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023128 Css NA 0.02164 mg/L PBTK NA 50% Rat Human +DTXSID9023128 Css NA 0.08606 mg/L PBTK NA 95% Rat Human +DTXSID9023170 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023170 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023170 Vd NA 2.294 L/kg 1compartment NA NA Human Human DTXSID9023170 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023170 TK.Half.Life NA 2.199 hours 1compartment NA NA Human Human -DTXSID9023170 Css NA 0.056 mg/L 3compartmentss NA 50% Human Human -DTXSID9023170 Css NA 0.4246 mg/L 3compartmentss NA 95% Human Human -DTXSID9023170 Css NA 0.039 mg/L PBTK NA 50% Human Human -DTXSID9023170 Css NA 0.2777 mg/L PBTK NA 95% Human Human -DTXSID9023170 Clint NA 89.61 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023170 Fup NA 0.1498 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023170 Vd NA 1.426 L/kg 1compartment NA NA Rat Human +DTXSID9023170 TK.Half.Life NA 5.97 hours 1compartment NA NA Human Human +DTXSID9023170 Css NA 0.2198 mg/L 3compartmentss NA 50% Human Human +DTXSID9023170 Css NA 1.422 mg/L 3compartmentss NA 95% Human Human +DTXSID9023170 Css NA 0.157 mg/L PBTK NA 50% Human Human +DTXSID9023170 Css NA 0.9554 mg/L PBTK NA 95% Human Human +DTXSID9023170 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023170 Fup 0.172 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023170 Vd NA 1.749 L/kg 1compartment NA NA Rat Human DTXSID9023170 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023170 TK.Half.Life NA 0.7592 hours 1compartment NA NA Rat Human -DTXSID9023170 Css NA 0.03142 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023170 Css NA 0.1894 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023170 Css NA 0.02083 mg/L PBTK NA 50% Rat Human -DTXSID9023170 Css NA 0.1207 mg/L PBTK NA 95% Rat Human -DTXSID9023174 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023174 Fup NA 0.9199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023174 Vd NA 6.422 L/kg 1compartment NA NA Human Human -DTXSID9023174 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9023174 TK.Half.Life NA 15.71 hours 1compartment NA NA Human Human -DTXSID9023174 Css NA 0.132 mg/L 3compartmentss NA 50% Human Human -DTXSID9023174 Css NA 0.9907 mg/L 3compartmentss NA 95% Human Human -DTXSID9023174 Css NA 0.1931 mg/L PBTK NA 50% Human Human -DTXSID9023174 Css NA 1.134 mg/L PBTK NA 95% Human Human -DTXSID9023174 Clint NA 4.234 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023174 Fup NA 0.9199 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023174 Vd NA 6.084 L/kg 1compartment NA NA Rat Human +DTXSID9023170 TK.Half.Life NA 1.807 hours 1compartment NA NA Rat Human +DTXSID9023170 Css NA 0.0278 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023170 Css NA 0.1375 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023170 Css NA 0.0198 mg/L PBTK NA 50% Rat Human +DTXSID9023170 Css NA 0.09435 mg/L PBTK NA 95% Rat Human +DTXSID9023174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023174 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023174 Vd NA 2.015 L/kg 1compartment NA NA Human Human +DTXSID9023174 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023174 TK.Half.Life NA 5.884 hours 1compartment NA NA Human Human +DTXSID9023174 Css NA 0.3364 mg/L 3compartmentss NA 50% Human Human +DTXSID9023174 Css NA 3.291 mg/L 3compartmentss NA 95% Human Human +DTXSID9023174 Css NA 0.2456 mg/L PBTK NA 50% Human Human +DTXSID9023174 Css NA 2.148 mg/L PBTK NA 95% Human Human +DTXSID9023174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023174 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023174 Vd NA 1.854 L/kg 1compartment NA NA Rat Human DTXSID9023174 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023174 TK.Half.Life NA 3.961 hours 1compartment NA NA Rat Human -DTXSID9023174 Css NA 0.06604 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023174 Css NA 0.3589 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023174 Css NA 0.09818 mg/L PBTK NA 50% Rat Human -DTXSID9023174 Css NA 0.417 mg/L PBTK NA 95% Rat Human -DTXSID9023176 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9023174 TK.Half.Life NA 3.092 hours 1compartment NA NA Rat Human +DTXSID9023174 Css NA 0.04326 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023174 Css NA 0.3605 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023174 Css NA 0.03111 mg/L PBTK NA 50% Rat Human +DTXSID9023174 Css NA 0.2277 mg/L PBTK NA 95% Rat Human +DTXSID9023176 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9023176 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9023176 Vd NA 0.544 L/kg 1compartment NA NA Human Human DTXSID9023176 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9023176 TK.Half.Life NA 3.52 hours 1compartment NA NA Human Human -DTXSID9023176 Css NA 0.907 mg/L 3compartmentss NA 50% Human Human -DTXSID9023176 Css NA 5.647 mg/L 3compartmentss NA 95% Human Human -DTXSID9023176 Css NA 0.6984 mg/L PBTK NA 50% Human Human -DTXSID9023176 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID9023176 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9023176 Css NA 0.8712 mg/L 3compartmentss NA 50% Human Human +DTXSID9023176 Css NA 5.713 mg/L 3compartmentss NA 95% Human Human +DTXSID9023176 Css NA 0.6743 mg/L PBTK NA 50% Human Human +DTXSID9023176 Css NA 3.677 mg/L PBTK NA 95% Human Human +DTXSID9023176 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9023176 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9023176 Vd NA 0.5641 L/kg 1compartment NA NA Rat Human DTXSID9023176 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9023176 TK.Half.Life NA 1.244 hours 1compartment NA NA Rat Human -DTXSID9023176 Css NA 0.23 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023176 Css NA 1.345 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023176 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID9023176 Css NA 0.7874 mg/L PBTK NA 95% Rat Human +DTXSID9023176 Css NA 0.05154 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023176 Css NA 0.297 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023176 Css NA 0.03996 mg/L PBTK NA 50% Rat Human +DTXSID9023176 Css NA 0.1803 mg/L PBTK NA 95% Rat Human DTXSID9023201 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID9023201 Fup NA 0.0411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023201 Vd NA 1.482 L/kg 1compartment NA NA Human Human -DTXSID9023201 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID9023201 TK.Half.Life NA 44.29 hours 1compartment NA NA Human Human -DTXSID9023201 Css NA 4.948 mg/L 3compartmentss NA 50% Human Human -DTXSID9023201 Css NA 32.38 mg/L 3compartmentss NA 95% Human Human -DTXSID9023201 Css NA 3.141 mg/L PBTK NA 50% Human Human -DTXSID9023201 Css NA 19.51 mg/L PBTK NA 95% Human Human +DTXSID9023201 Fup 0.0673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023201 Vd NA 1.341 L/kg 1compartment NA NA Human Human +DTXSID9023201 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9023201 TK.Half.Life NA 24.92 hours 1compartment NA NA Human Human +DTXSID9023201 Css NA 2.71 mg/L 3compartmentss NA 50% Human Human +DTXSID9023201 Css NA 14.29 mg/L 3compartmentss NA 95% Human Human +DTXSID9023201 Css NA 1.753 mg/L PBTK NA 50% Human Human +DTXSID9023201 Css NA 8.743 mg/L PBTK NA 95% Human Human DTXSID9023201 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID9023201 Fup NA 0.0411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023201 Vd NA 1.11 L/kg 1compartment NA NA Rat Human -DTXSID9023201 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9023201 TK.Half.Life NA 15.82 hours 1compartment NA NA Rat Human -DTXSID9023201 Css NA 2.478 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023201 Css NA 12.39 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023201 Css NA 1.48 mg/L PBTK NA 50% Rat Human -DTXSID9023201 Css NA 6.936 mg/L PBTK NA 95% Rat Human -DTXSID9023205 Clint NA 6.114 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023205 Fup NA 0.1323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023205 Vd NA 2.712 L/kg 1compartment NA NA Human Human -DTXSID9023205 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9023205 TK.Half.Life NA 29.5 hours 1compartment NA NA Human Human -DTXSID9023205 Css NA 1.325 mg/L 3compartmentss NA 50% Human Human -DTXSID9023205 Css NA 7.69 mg/L 3compartmentss NA 95% Human Human -DTXSID9023205 Css NA 0.9547 mg/L PBTK NA 50% Human Human -DTXSID9023205 Css NA 5.133 mg/L PBTK NA 95% Human Human -DTXSID9023205 Clint NA 6.114 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023205 Fup NA 0.1323 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023205 Vd NA 2.104 L/kg 1compartment NA NA Rat Human -DTXSID9023205 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9023205 TK.Half.Life NA 7.191 hours 1compartment NA NA Rat Human -DTXSID9023205 Css NA 0.7023 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023205 Css NA 2.803 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023205 Css NA 0.4838 mg/L PBTK NA 50% Rat Human -DTXSID9023205 Css NA 1.789 mg/L PBTK NA 95% Rat Human -DTXSID9023209 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9023201 Fup 0.0673 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023201 Vd NA 1.019 L/kg 1compartment NA NA Rat Human +DTXSID9023201 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9023201 TK.Half.Life NA 9.374 hours 1compartment NA NA Rat Human +DTXSID9023201 Css NA 0.3119 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023201 Css NA 1.173 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023201 Css NA 0.1968 mg/L PBTK NA 50% Rat Human +DTXSID9023201 Css NA 0.693 mg/L PBTK NA 95% Rat Human +DTXSID9023205 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023205 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023205 Vd NA 4.476 L/kg 1compartment NA NA Human Human +DTXSID9023205 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023205 TK.Half.Life NA 4.34 hours 1compartment NA NA Human Human +DTXSID9023205 Css NA 0.03707 mg/L 3compartmentss NA 50% Human Human +DTXSID9023205 Css NA 0.323 mg/L 3compartmentss NA 95% Human Human +DTXSID9023205 Css NA 0.04636 mg/L PBTK NA 50% Human Human +DTXSID9023205 Css NA 0.3331 mg/L PBTK NA 95% Human Human +DTXSID9023205 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023205 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023205 Vd NA 4.419 L/kg 1compartment NA NA Rat Human +DTXSID9023205 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9023205 TK.Half.Life NA 2.205 hours 1compartment NA NA Rat Human +DTXSID9023205 Css NA 0.004511 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023205 Css NA 0.03077 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023205 Css NA 0.005948 mg/L PBTK NA 50% Rat Human +DTXSID9023205 Css NA 0.03181 mg/L PBTK NA 95% Rat Human +DTXSID9023207 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023207 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9023207 Vd NA 0.6942 L/kg 1compartment NA NA Human Human +DTXSID9023207 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023207 TK.Half.Life NA 4.99 hours 1compartment NA NA Human Human +DTXSID9023207 Css NA 0.6735 mg/L 3compartmentss NA 50% Human Human +DTXSID9023207 Css NA 2.207 mg/L 3compartmentss NA 95% Human Human +DTXSID9023207 Css NA 0.7206 mg/L PBTK NA 50% Human Human +DTXSID9023207 Css NA 2.362 mg/L PBTK NA 95% Human Human +DTXSID9023207 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023207 Fup 0.9 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9023207 Vd NA 0.7343 L/kg 1compartment NA NA Rat Human +DTXSID9023207 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9023207 TK.Half.Life NA 1.799 hours 1compartment NA NA Rat Human +DTXSID9023207 Css NA 0.03902 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023207 Css NA 0.1088 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023207 Css NA 0.04324 mg/L PBTK NA 50% Rat Human +DTXSID9023207 Css NA 0.1206 mg/L PBTK NA 95% Rat Human +DTXSID9023209 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9023209 Fup 0.76 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9023209 Vd NA 0.5933 L/kg 1compartment NA NA Human Human DTXSID9023209 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9023209 TK.Half.Life NA 5.052 hours 1compartment NA NA Human Human -DTXSID9023209 Css NA 1.065 mg/L 3compartmentss NA 50% Human Human -DTXSID9023209 Css NA 6.292 mg/L 3compartmentss NA 95% Human Human -DTXSID9023209 Css NA 0.8392 mg/L PBTK NA 50% Human Human -DTXSID9023209 Css NA 3.977 mg/L PBTK NA 95% Human Human -DTXSID9023209 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9023209 Css NA 0.5775 mg/L 3compartmentss NA 50% Human Human +DTXSID9023209 Css NA 3.63 mg/L 3compartmentss NA 95% Human Human +DTXSID9023209 Css NA 0.4557 mg/L PBTK NA 50% Human Human +DTXSID9023209 Css NA 2.307 mg/L PBTK NA 95% Human Human +DTXSID9023209 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9023209 Fup 0.76 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9023209 Vd NA 0.6346 L/kg 1compartment NA NA Rat Human DTXSID9023209 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9023209 TK.Half.Life NA 1.841 hours 1compartment NA NA Rat Human -DTXSID9023209 Css NA 0.2762 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023209 Css NA 1.702 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023209 Css NA 0.2095 mg/L PBTK NA 50% Rat Human -DTXSID9023209 Css NA 0.9975 mg/L PBTK NA 95% Rat Human -DTXSID9023255 Clint NA 99.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023255 Fup NA 0.3225 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023255 Vd NA 0.7424 L/kg 1compartment NA NA Human Human +DTXSID9023209 Css NA 0.003006 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023209 Css NA 0.01995 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023209 Css NA 0.002292 mg/L PBTK NA 50% Rat Human +DTXSID9023209 Css NA 0.01232 mg/L PBTK NA 95% Rat Human +DTXSID9023253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023253 Fup 0.42 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9023253 Vd NA 4.497 L/kg 1compartment NA NA Human Human +DTXSID9023253 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023253 TK.Half.Life NA 4.362 hours 1compartment NA NA Human Human +DTXSID9023253 Css NA 0.03598 mg/L 3compartmentss NA 50% Human Human +DTXSID9023253 Css NA 0.2765 mg/L 3compartmentss NA 95% Human Human +DTXSID9023253 Css NA 0.03115 mg/L PBTK NA 50% Human Human +DTXSID9023253 Css NA 0.2399 mg/L PBTK NA 95% Human Human +DTXSID9023253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023253 Fup 0.42 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9023253 Vd NA 4.565 L/kg 1compartment NA NA Rat Human +DTXSID9023253 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9023253 TK.Half.Life NA 2.236 hours 1compartment NA NA Rat Human +DTXSID9023253 Css NA 0.004334 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023253 Css NA 0.025 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023253 Css NA 0.003912 mg/L PBTK NA 50% Rat Human +DTXSID9023253 Css NA 0.02253 mg/L PBTK NA 95% Rat Human +DTXSID9023255 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023255 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023255 Vd NA 0.9142 L/kg 1compartment NA NA Human Human DTXSID9023255 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023255 TK.Half.Life NA 0.6412 hours 1compartment NA NA Human Human -DTXSID9023255 Css NA 0.01495 mg/L 3compartmentss NA 50% Human Human -DTXSID9023255 Css NA 0.1184 mg/L 3compartmentss NA 95% Human Human -DTXSID9023255 Css NA 0.0108 mg/L PBTK NA 50% Human Human -DTXSID9023255 Css NA 0.0782 mg/L PBTK NA 95% Human Human -DTXSID9023255 Clint NA 99.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023255 Fup NA 0.3225 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023255 Vd NA 0.6733 L/kg 1compartment NA NA Rat Human +DTXSID9023255 TK.Half.Life NA 1.031 hours 1compartment NA NA Human Human +DTXSID9023255 Css NA 0.04945 mg/L 3compartmentss NA 50% Human Human +DTXSID9023255 Css NA 0.416 mg/L 3compartmentss NA 95% Human Human +DTXSID9023255 Css NA 0.03772 mg/L PBTK NA 50% Human Human +DTXSID9023255 Css NA 0.2838 mg/L PBTK NA 95% Human Human +DTXSID9023255 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023255 Fup 0.394 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023255 Vd NA 0.8147 L/kg 1compartment NA NA Rat Human DTXSID9023255 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023255 TK.Half.Life NA 0.2699 hours 1compartment NA NA Rat Human -DTXSID9023255 Css NA 0.008208 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023255 Css NA 0.05257 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023255 Css NA 0.00571 mg/L PBTK NA 50% Rat Human -DTXSID9023255 Css NA 0.0339 mg/L PBTK NA 95% Rat Human +DTXSID9023255 TK.Half.Life NA 0.4683 hours 1compartment NA NA Rat Human +DTXSID9023255 Css NA 0.006167 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023255 Css NA 0.03769 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023255 Css NA 0.00471 mg/L PBTK NA 50% Rat Human +DTXSID9023255 Css NA 0.02583 mg/L PBTK NA 95% Rat Human +DTXSID9023259 Clint 1 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID9023259 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9023259 Vd NA 1.951 L/kg 1compartment NA NA Human Human +DTXSID9023259 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9023259 TK.Half.Life NA 17.46 hours 1compartment NA NA Human Human +DTXSID9023259 Css NA 0.7952 mg/L 3compartmentss NA 50% Human Human +DTXSID9023259 Css NA 3.123 mg/L 3compartmentss NA 95% Human Human +DTXSID9023259 Css NA 0.7143 mg/L PBTK NA 50% Human Human +DTXSID9023259 Css NA 2.809 mg/L PBTK NA 95% Human Human +DTXSID9023259 Clint 1 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID9023259 Fup 0.3 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9023259 Vd NA 1.849 L/kg 1compartment NA NA Rat Human +DTXSID9023259 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9023259 TK.Half.Life NA 7.661 hours 1compartment NA NA Rat Human +DTXSID9023259 Css NA 0.07096 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023259 Css NA 0.217 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023259 Css NA 0.06612 mg/L PBTK NA 50% Rat Human +DTXSID9023259 Css NA 0.2023 mg/L PBTK NA 95% Rat Human +DTXSID9023330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023330 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9023330 Vd NA 1.631 L/kg 1compartment NA NA Human Human +DTXSID9023330 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023330 TK.Half.Life NA 3.825 hours 1compartment NA NA Human Human +DTXSID9023330 Css NA 0.1964 mg/L 3compartmentss NA 50% Human Human +DTXSID9023330 Css NA 1.612 mg/L 3compartmentss NA 95% Human Human +DTXSID9023330 Css NA 0.1376 mg/L PBTK NA 50% Human Human +DTXSID9023330 Css NA 1.047 mg/L PBTK NA 95% Human Human +DTXSID9023330 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023330 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9023330 Vd NA 1.383 L/kg 1compartment NA NA Rat Human +DTXSID9023330 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9023330 TK.Half.Life NA 1.722 hours 1compartment NA NA Rat Human +DTXSID9023330 Css NA 0.009423 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023330 Css NA 0.08506 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023330 Css NA 0.006486 mg/L PBTK NA 50% Rat Human +DTXSID9023330 Css NA 0.05352 mg/L PBTK NA 95% Rat Human DTXSID9023334 Clint 29.6 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID9023334 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9023334 Vd NA 303.6 L/kg 1compartment NA NA Human Human -DTXSID9023334 Days.Css NA 2911 Days PBTK NA NA Human Human -DTXSID9023334 TK.Half.Life NA 10660 hours 1compartment NA NA Human Human -DTXSID9023334 Css NA 4.332 mg/L 3compartmentss NA 50% Human Human -DTXSID9023334 Css NA 39.97 mg/L 3compartmentss NA 95% Human Human -DTXSID9023334 Css NA 2.482 mg/L PBTK NA 50% Human Human -DTXSID9023334 Css NA 23.05 mg/L PBTK NA 95% Human Human +DTXSID9023334 Vd NA 17.48 L/kg 1compartment NA NA Human Human +DTXSID9023334 Days.Css NA 144 Days PBTK NA NA Human Human +DTXSID9023334 TK.Half.Life NA 613.9 hours 1compartment NA NA Human Human +DTXSID9023334 Css NA 6.706 mg/L 3compartmentss NA 50% Human Human +DTXSID9023334 Css NA 62.62 mg/L 3compartmentss NA 95% Human Human +DTXSID9023334 Css NA 3.689 mg/L PBTK NA 50% Human Human +DTXSID9023334 Css NA 34.44 mg/L PBTK NA 95% Human Human DTXSID9023334 Clint 29.6 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID9023334 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9023334 Vd NA 271.1 L/kg 1compartment NA NA Rat Human -DTXSID9023334 Days.Css NA 1788 Days PBTK NA NA Rat Human -DTXSID9023334 TK.Half.Life NA 5849 hours 1compartment NA NA Rat Human -DTXSID9023334 Css NA 3.859 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023334 Css NA 27.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023334 Css NA 2.055 mg/L PBTK NA 50% Rat Human -DTXSID9023334 Css NA 14.75 mg/L PBTK NA 95% Rat Human +DTXSID9023334 Vd NA 14.11 L/kg 1compartment NA NA Rat Human +DTXSID9023334 Days.Css NA 81 Days PBTK NA NA Rat Human +DTXSID9023334 TK.Half.Life NA 304.5 hours 1compartment NA NA Rat Human +DTXSID9023334 Css NA 0.8418 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023334 Css NA 6.679 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023334 Css NA 0.4795 mg/L PBTK NA 50% Rat Human +DTXSID9023334 Css NA 3.805 mg/L PBTK NA 95% Rat Human DTXSID9023336 Clint 24 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Human Human DTXSID9023336 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9023336 Vd NA 2.584 L/kg 1compartment NA NA Human Human DTXSID9023336 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9023336 TK.Half.Life NA 1.993 hours 1compartment NA NA Human Human -DTXSID9023336 Css NA 0.02706 mg/L 3compartmentss NA 50% Human Human -DTXSID9023336 Css NA 0.3083 mg/L 3compartmentss NA 95% Human Human -DTXSID9023336 Css NA 0.02453 mg/L PBTK NA 50% Human Human -DTXSID9023336 Css NA 0.2194 mg/L PBTK NA 95% Human Human +DTXSID9023336 Css NA 0.02314 mg/L 3compartmentss NA 50% Human Human +DTXSID9023336 Css NA 0.2343 mg/L 3compartmentss NA 95% Human Human +DTXSID9023336 Css NA 0.02184 mg/L PBTK NA 50% Human Human +DTXSID9023336 Css NA 0.2221 mg/L PBTK NA 95% Human Human DTXSID9023336 Clint 24 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.104.000026 NA Rat Human DTXSID9023336 Fup 0.65 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9023336 Vd NA 2.82 L/kg 1compartment NA NA Rat Human DTXSID9023336 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9023336 TK.Half.Life NA 1.029 hours 1compartment NA NA Rat Human -DTXSID9023336 Css NA 0.01288 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023336 Css NA 0.1169 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023336 Css NA 0.01148 mg/L PBTK NA 50% Rat Human -DTXSID9023336 Css NA 0.07973 mg/L PBTK NA 95% Rat Human +DTXSID9023336 Css NA 0.002536 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023336 Css NA 0.01977 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023336 Css NA 0.0025 mg/L PBTK NA 50% Rat Human +DTXSID9023336 Css NA 0.01945 mg/L PBTK NA 95% Rat Human +DTXSID9023338 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023338 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9023338 Vd NA 0.3966 L/kg 1compartment NA NA Human Human +DTXSID9023338 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023338 TK.Half.Life NA 6.583 hours 1compartment NA NA Human Human +DTXSID9023338 Css NA 1.039 mg/L 3compartmentss NA 50% Human Human +DTXSID9023338 Css NA 4.782 mg/L 3compartmentss NA 95% Human Human +DTXSID9023338 Css NA 0.7301 mg/L PBTK NA 50% Human Human +DTXSID9023338 Css NA 3.012 mg/L PBTK NA 95% Human Human +DTXSID9023338 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023338 Fup 0.39 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9023338 Vd NA 0.4117 L/kg 1compartment NA NA Rat Human +DTXSID9023338 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9023338 TK.Half.Life NA 2.328 hours 1compartment NA NA Rat Human +DTXSID9023338 Css NA 0.005618 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023338 Css NA 0.02557 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023338 Css NA 0.00378 mg/L PBTK NA 50% Rat Human +DTXSID9023338 Css NA 0.01538 mg/L PBTK NA 95% Rat Human DTXSID9023380 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9023380 Fup 0.0516 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9023380 Vd NA 1.404 L/kg 1compartment NA NA Human Human DTXSID9023380 Days.Css NA 53 Days PBTK NA NA Human Human DTXSID9023380 TK.Half.Life NA 237.8 hours 1compartment NA NA Human Human -DTXSID9023380 Css NA 12.78 mg/L 3compartmentss NA 50% Human Human -DTXSID9023380 Css NA 61.98 mg/L 3compartmentss NA 95% Human Human -DTXSID9023380 Css NA 8.425 mg/L PBTK NA 50% Human Human -DTXSID9023380 Css NA 37.57 mg/L PBTK NA 95% Human Human +DTXSID9023380 Css NA 12.38 mg/L 3compartmentss NA 50% Human Human +DTXSID9023380 Css NA 60.45 mg/L 3compartmentss NA 95% Human Human +DTXSID9023380 Css NA 8.256 mg/L PBTK NA 50% Human Human +DTXSID9023380 Css NA 36.69 mg/L PBTK NA 95% Human Human DTXSID9023380 Clint 53.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9023380 Fup 0.029 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9023380 Vd NA 0.7995 L/kg 1compartment NA NA Rat Rat DTXSID9023380 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9023380 TK.Half.Life NA 1.47 hours 1compartment NA NA Rat Rat -DTXSID9023380 Css NA 0.2455 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9023380 Css NA 1.871 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9023380 Css NA 0.1414 mg/L PBTK NA 50% Rat Rat -DTXSID9023380 Css NA 1.05 mg/L PBTK NA 95% Rat Rat +DTXSID9023380 Css NA 0.0557 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9023380 Css NA 0.4436 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9023380 Css NA 0.03321 mg/L PBTK NA 50% Rat Rat +DTXSID9023380 Css NA 0.254 mg/L PBTK NA 95% Rat Rat DTXSID9023384 Clint 9.865e-06 NA uL/min/million hepatocytes NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human DTXSID9023384 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9023384 Vd NA 2.794 L/kg 1compartment NA NA Human Human DTXSID9023384 Days.Css NA 34 Days PBTK NA NA Human Human DTXSID9023384 TK.Half.Life NA 157.1 hours 1compartment NA NA Human Human -DTXSID9023384 Css NA 2.968 mg/L 3compartmentss NA 50% Human Human -DTXSID9023384 Css NA 21.63 mg/L 3compartmentss NA 95% Human Human -DTXSID9023384 Css NA 3.894 mg/L PBTK NA 50% Human Human -DTXSID9023384 Css NA 17.1 mg/L PBTK NA 95% Human Human +DTXSID9023384 Css NA 3.485 mg/L 3compartmentss NA 50% Human Human +DTXSID9023384 Css NA 14.9 mg/L 3compartmentss NA 95% Human Human +DTXSID9023384 Css NA 5.227 mg/L PBTK NA 50% Human Human +DTXSID9023384 Css NA 22.35 mg/L PBTK NA 95% Human Human DTXSID9023384 Clint 9.865e-06 NA uL/min/million hepatocytes NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human DTXSID9023384 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9023384 Vd NA 2.743 L/kg 1compartment NA NA Rat Human DTXSID9023384 Days.Css NA 9 Days PBTK NA NA Rat Human DTXSID9023384 TK.Half.Life NA 50.89 hours 1compartment NA NA Rat Human -DTXSID9023384 Css NA 1.07 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023384 Css NA 6.897 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023384 Css NA 1.404 mg/L PBTK NA 50% Rat Human -DTXSID9023384 Css NA 5.171 mg/L PBTK NA 95% Rat Human -DTXSID9023386 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023386 Fup NA 0.0281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023386 Vd NA 0.2066 L/kg 1compartment NA NA Human Human +DTXSID9023384 Css NA 0.2095 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023384 Css NA 0.784 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023384 Css NA 0.3254 mg/L PBTK NA 50% Rat Human +DTXSID9023384 Css NA 1.218 mg/L PBTK NA 95% Rat Human +DTXSID9023386 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023386 Fup 0.0993 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023386 Vd NA 0.3688 L/kg 1compartment NA NA Human Human DTXSID9023386 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023386 TK.Half.Life NA 0.9663 hours 1compartment NA NA Human Human -DTXSID9023386 Css NA 0.7374 mg/L 3compartmentss NA 50% Human Human -DTXSID9023386 Css NA 7 mg/L 3compartmentss NA 95% Human Human -DTXSID9023386 Css NA 0.4384 mg/L PBTK NA 50% Human Human -DTXSID9023386 Css NA 4.06 mg/L PBTK NA 95% Human Human -DTXSID9023386 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023386 Fup NA 0.0281 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023386 Vd NA 0.202 L/kg 1compartment NA NA Rat Human +DTXSID9023386 TK.Half.Life NA 0.9521 hours 1compartment NA NA Human Human +DTXSID9023386 Css NA 0.1432 mg/L 3compartmentss NA 50% Human Human +DTXSID9023386 Css NA 1.365 mg/L 3compartmentss NA 95% Human Human +DTXSID9023386 Css NA 0.09182 mg/L PBTK NA 50% Human Human +DTXSID9023386 Css NA 0.838 mg/L PBTK NA 95% Human Human +DTXSID9023386 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023386 Fup 0.0993 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023386 Vd NA 0.3524 L/kg 1compartment NA NA Rat Human DTXSID9023386 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023386 TK.Half.Life NA 0.6017 hours 1compartment NA NA Rat Human -DTXSID9023386 Css NA 0.4114 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023386 Css NA 3.149 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023386 Css NA 0.2275 mg/L PBTK NA 50% Rat Human -DTXSID9023386 Css NA 1.71 mg/L PBTK NA 95% Rat Human +DTXSID9023386 TK.Half.Life NA 0.5415 hours 1compartment NA NA Rat Human +DTXSID9023386 Css NA 0.001546 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023386 Css NA 0.01225 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023386 Css NA 0.0009283 mg/L PBTK NA 50% Rat Human +DTXSID9023386 Css NA 0.007077 mg/L PBTK NA 95% Rat Human DTXSID9023388 Clint 2 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Human Human -DTXSID9023388 Fup NA 0.2003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023388 Vd NA 3.616 L/kg 1compartment NA NA Human Human +DTXSID9023388 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023388 Vd NA 2.105 L/kg 1compartment NA NA Human Human DTXSID9023388 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9023388 TK.Half.Life NA 27.02 hours 1compartment NA NA Human Human -DTXSID9023388 Css NA 0.5848 mg/L 3compartmentss NA 50% Human Human -DTXSID9023388 Css NA 3.111 mg/L 3compartmentss NA 95% Human Human -DTXSID9023388 Css NA 0.611 mg/L PBTK NA 50% Human Human -DTXSID9023388 Css NA 2.652 mg/L PBTK NA 95% Human Human +DTXSID9023388 TK.Half.Life NA 23.75 hours 1compartment NA NA Human Human +DTXSID9023388 Css NA 1.22 mg/L 3compartmentss NA 50% Human Human +DTXSID9023388 Css NA 5.122 mg/L 3compartmentss NA 95% Human Human +DTXSID9023388 Css NA 0.9112 mg/L PBTK NA 50% Human Human +DTXSID9023388 Css NA 3.497 mg/L PBTK NA 95% Human Human DTXSID9023388 Clint 2 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Rat Human -DTXSID9023388 Fup NA 0.2003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023388 Vd NA 3.617 L/kg 1compartment NA NA Rat Human +DTXSID9023388 Fup 0.217 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023388 Vd NA 1.654 L/kg 1compartment NA NA Rat Human DTXSID9023388 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9023388 TK.Half.Life NA 13.92 hours 1compartment NA NA Rat Human -DTXSID9023388 Css NA 0.2623 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023388 Css NA 1.146 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023388 Css NA 0.2726 mg/L PBTK NA 50% Rat Human -DTXSID9023388 Css NA 0.8639 mg/L PBTK NA 95% Rat Human -DTXSID9023411 Clint NA 50.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023411 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023411 Vd NA 2.946 L/kg 1compartment NA NA Human Human -DTXSID9023411 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9023411 TK.Half.Life NA 27.56 hours 1compartment NA NA Human Human -DTXSID9023411 Css NA 1.165 mg/L 3compartmentss NA 50% Human Human -DTXSID9023411 Css NA 7.476 mg/L 3compartmentss NA 95% Human Human -DTXSID9023411 Css NA 0.7926 mg/L PBTK NA 50% Human Human -DTXSID9023411 Css NA 4.95 mg/L PBTK NA 95% Human Human -DTXSID9023411 Clint NA 50.25 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023411 Fup NA 0.0148 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023411 Vd NA 2.204 L/kg 1compartment NA NA Rat Human -DTXSID9023411 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9023411 TK.Half.Life NA 4.881 hours 1compartment NA NA Rat Human -DTXSID9023411 Css NA 0.657 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023411 Css NA 3.554 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023411 Css NA 0.4272 mg/L PBTK NA 50% Rat Human -DTXSID9023411 Css NA 2.223 mg/L PBTK NA 95% Rat Human -DTXSID9023413 Clint NA 659.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9023388 TK.Half.Life NA 7.108 hours 1compartment NA NA Rat Human +DTXSID9023388 Css NA 0.1289 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023388 Css NA 0.405 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023388 Css NA 0.09548 mg/L PBTK NA 50% Rat Human +DTXSID9023388 Css NA 0.2648 mg/L PBTK NA 95% Rat Human +DTXSID9023411 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023411 Fup 0.0082 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023411 Vd NA 2.594 L/kg 1compartment NA NA Human Human +DTXSID9023411 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID9023411 TK.Half.Life NA 51.77 hours 1compartment NA NA Human Human +DTXSID9023411 Css NA 2.822 mg/L 3compartmentss NA 50% Human Human +DTXSID9023411 Css NA 20.86 mg/L 3compartmentss NA 95% Human Human +DTXSID9023411 Css NA 1.862 mg/L PBTK NA 50% Human Human +DTXSID9023411 Css NA 13.16 mg/L PBTK NA 95% Human Human +DTXSID9023411 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023411 Fup 0.0082 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023411 Vd NA 1.933 L/kg 1compartment NA NA Rat Human +DTXSID9023411 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID9023411 TK.Half.Life NA 11.84 hours 1compartment NA NA Rat Human +DTXSID9023411 Css NA 0.3612 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023411 Css NA 2.306 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023411 Css NA 0.2348 mg/L PBTK NA 50% Rat Human +DTXSID9023411 Css NA 1.422 mg/L PBTK NA 95% Rat Human +DTXSID9023413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9023413 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9023413 Vd NA 0.3395 L/kg 1compartment NA NA Human Human +DTXSID9023413 Vd NA 0.6408 L/kg 1compartment NA NA Human Human DTXSID9023413 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023413 TK.Half.Life NA 0.32 hours 1compartment NA NA Human Human -DTXSID9023413 Css NA 0.008322 mg/L 3compartmentss NA 50% Human Human -DTXSID9023413 Css NA 0.07055 mg/L 3compartmentss NA 95% Human Human -DTXSID9023413 Css NA 0.005192 mg/L PBTK NA 50% Human Human -DTXSID9023413 Css NA 0.0424 mg/L PBTK NA 95% Human Human -DTXSID9023413 Clint NA 659.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9023413 TK.Half.Life NA 1.453 hours 1compartment NA NA Human Human +DTXSID9023413 Css NA 0.223 mg/L 3compartmentss NA 50% Human Human +DTXSID9023413 Css NA 1.861 mg/L 3compartmentss NA 95% Human Human +DTXSID9023413 Css NA 0.144 mg/L PBTK NA 50% Human Human +DTXSID9023413 Css NA 1.139 mg/L PBTK NA 95% Human Human +DTXSID9023413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9023413 Fup 0.12 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9023413 Vd NA 0.3179 L/kg 1compartment NA NA Rat Human +DTXSID9023413 Vd NA 0.5332 L/kg 1compartment NA NA Rat Human DTXSID9023413 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023413 TK.Half.Life NA 0.1347 hours 1compartment NA NA Rat Human -DTXSID9023413 Css NA 0.00476 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023413 Css NA 0.03427 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023413 Css NA 0.002793 mg/L PBTK NA 50% Rat Human -DTXSID9023413 Css NA 0.01955 mg/L PBTK NA 95% Rat Human -DTXSID9023415 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9023413 TK.Half.Life NA 0.6911 hours 1compartment NA NA Rat Human +DTXSID9023413 Css NA 0.02899 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023413 Css NA 0.1862 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023413 Css NA 0.01843 mg/L PBTK NA 50% Rat Human +DTXSID9023413 Css NA 0.1102 mg/L PBTK NA 95% Rat Human +DTXSID9023415 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9023415 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9023415 Vd NA 3.18 L/kg 1compartment NA NA Human Human -DTXSID9023415 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID9023415 TK.Half.Life NA 16320 hours 1compartment NA NA Human Human -DTXSID9023415 Css NA 574.2 mg/L 3compartmentss NA 50% Human Human -DTXSID9023415 Css NA 1614 mg/L 3compartmentss NA 95% Human Human -DTXSID9023415 Css NA 407.4 mg/L PBTK NA 50% Human Human -DTXSID9023415 Css NA 1058 mg/L PBTK NA 95% Human Human -DTXSID9023415 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9023415 Vd NA 3.19 L/kg 1compartment NA NA Human Human +DTXSID9023415 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID9023415 TK.Half.Life NA 46.96 hours 1compartment NA NA Human Human +DTXSID9023415 Css NA 1.673 mg/L 3compartmentss NA 50% Human Human +DTXSID9023415 Css NA 10.73 mg/L 3compartmentss NA 95% Human Human +DTXSID9023415 Css NA 1.235 mg/L PBTK NA 50% Human Human +DTXSID9023415 Css NA 7.471 mg/L PBTK NA 95% Human Human +DTXSID9023415 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9023415 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9023415 Vd NA 2.407 L/kg 1compartment NA NA Rat Human -DTXSID9023415 Days.Css NA 1158 Days PBTK NA NA Rat Human -DTXSID9023415 TK.Half.Life NA 1048 hours 1compartment NA NA Rat Human -DTXSID9023415 Css NA 155.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023415 Css NA 347.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023415 Css NA 105.6 mg/L PBTK NA 50% Rat Human -DTXSID9023415 Css NA 211.5 mg/L PBTK NA 95% Rat Human -DTXSID9023419 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023419 Fup NA 0.8842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023419 Vd NA 1.094 L/kg 1compartment NA NA Human Human -DTXSID9023419 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023419 TK.Half.Life NA 8.246 hours 1compartment NA NA Human Human -DTXSID9023419 Css NA 0.8802 mg/L 3compartmentss NA 50% Human Human -DTXSID9023419 Css NA 5.144 mg/L 3compartmentss NA 95% Human Human -DTXSID9023419 Css NA 0.7846 mg/L PBTK NA 50% Human Human -DTXSID9023419 Css NA 3.49 mg/L PBTK NA 95% Human Human -DTXSID9023419 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023419 Fup NA 0.8842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023419 Vd NA 1.059 L/kg 1compartment NA NA Rat Human -DTXSID9023419 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023419 TK.Half.Life NA 2.66 hours 1compartment NA NA Rat Human -DTXSID9023419 Css NA 0.2219 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023419 Css NA 1.394 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023419 Css NA 0.1934 mg/L PBTK NA 50% Rat Human -DTXSID9023419 Css NA 0.8573 mg/L PBTK NA 95% Rat Human -DTXSID9023463 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023463 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023463 Vd NA 0.7539 L/kg 1compartment NA NA Human Human +DTXSID9023415 Vd NA 2.5 L/kg 1compartment NA NA Rat Human +DTXSID9023415 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID9023415 TK.Half.Life NA 8.859 hours 1compartment NA NA Rat Human +DTXSID9023415 Css NA 0.2114 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023415 Css NA 1.037 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023415 Css NA 0.1555 mg/L PBTK NA 50% Rat Human +DTXSID9023415 Css NA 0.7273 mg/L PBTK NA 95% Rat Human +DTXSID9023463 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023463 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023463 Vd NA 0.5143 L/kg 1compartment NA NA Human Human DTXSID9023463 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023463 TK.Half.Life NA 4.878 hours 1compartment NA NA Human Human -DTXSID9023463 Css NA 0.8348 mg/L 3compartmentss NA 50% Human Human -DTXSID9023463 Css NA 5.56 mg/L 3compartmentss NA 95% Human Human -DTXSID9023463 Css NA 0.6989 mg/L PBTK NA 50% Human Human -DTXSID9023463 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID9023463 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023463 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023463 Vd NA 0.7949 L/kg 1compartment NA NA Rat Human +DTXSID9023463 TK.Half.Life NA 6.436 hours 1compartment NA NA Human Human +DTXSID9023463 Css NA 1.408 mg/L 3compartmentss NA 50% Human Human +DTXSID9023463 Css NA 7.784 mg/L 3compartmentss NA 95% Human Human +DTXSID9023463 Css NA 1.057 mg/L PBTK NA 50% Human Human +DTXSID9023463 Css NA 4.864 mg/L PBTK NA 95% Human Human +DTXSID9023463 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023463 Fup 0.517 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023463 Vd NA 0.5403 L/kg 1compartment NA NA Rat Human DTXSID9023463 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023463 TK.Half.Life NA 1.753 hours 1compartment NA NA Rat Human -DTXSID9023463 Css NA 0.2096 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023463 Css NA 1.332 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023463 Css NA 0.1721 mg/L PBTK NA 50% Rat Human -DTXSID9023463 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID9023540 Clint NA 721.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023540 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023540 Vd NA 2.307 L/kg 1compartment NA NA Human Human +DTXSID9023463 TK.Half.Life NA 2.304 hours 1compartment NA NA Rat Human +DTXSID9023463 Css NA 0.08843 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023463 Css NA 0.4196 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023463 Css NA 0.06533 mg/L PBTK NA 50% Rat Human +DTXSID9023463 Css NA 0.2539 mg/L PBTK NA 95% Rat Human +DTXSID9023540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023540 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023540 Vd NA 1.112 L/kg 1compartment NA NA Human Human DTXSID9023540 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023540 TK.Half.Life NA 1.222 hours 1compartment NA NA Human Human -DTXSID9023540 Css NA 0.0007598 mg/L 3compartmentss NA 50% Human Human -DTXSID9023540 Css NA 0.01147 mg/L 3compartmentss NA 95% Human Human -DTXSID9023540 Css NA 0.0007515 mg/L PBTK NA 50% Human Human -DTXSID9023540 Css NA 0.009387 mg/L PBTK NA 95% Human Human -DTXSID9023540 Clint NA 721.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023540 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023540 Vd NA 1.932 L/kg 1compartment NA NA Rat Human +DTXSID9023540 TK.Half.Life NA 0.9431 hours 1compartment NA NA Human Human +DTXSID9023540 Css NA 0.02948 mg/L 3compartmentss NA 50% Human Human +DTXSID9023540 Css NA 0.3453 mg/L 3compartmentss NA 95% Human Human +DTXSID9023540 Css NA 0.02518 mg/L PBTK NA 50% Human Human +DTXSID9023540 Css NA 0.2414 mg/L PBTK NA 95% Human Human +DTXSID9023540 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023540 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023540 Vd NA 1.03 L/kg 1compartment NA NA Rat Human DTXSID9023540 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023540 TK.Half.Life NA 0.4324 hours 1compartment NA NA Rat Human -DTXSID9023540 Css NA 0.0003946 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023540 Css NA 0.00494 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023540 Css NA 0.0003909 mg/L PBTK NA 50% Rat Human -DTXSID9023540 Css NA 0.004053 mg/L PBTK NA 95% Rat Human -DTXSID9023542 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023542 Fup NA 0.2109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023542 Vd NA 3.481 L/kg 1compartment NA NA Human Human +DTXSID9023540 TK.Half.Life NA 0.4279 hours 1compartment NA NA Rat Human +DTXSID9023540 Css NA 0.003536 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023540 Css NA 0.03579 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023540 Css NA 0.003095 mg/L PBTK NA 50% Rat Human +DTXSID9023540 Css NA 0.02411 mg/L PBTK NA 95% Rat Human +DTXSID9023542 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023542 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023542 Vd NA 4.268 L/kg 1compartment NA NA Human Human DTXSID9023542 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023542 TK.Half.Life NA 6.118 hours 1compartment NA NA Human Human -DTXSID9023542 Css NA 0.1083 mg/L 3compartmentss NA 50% Human Human -DTXSID9023542 Css NA 0.7764 mg/L 3compartmentss NA 95% Human Human -DTXSID9023542 Css NA 0.1101 mg/L PBTK NA 50% Human Human -DTXSID9023542 Css NA 0.6954 mg/L PBTK NA 95% Human Human -DTXSID9023542 Clint NA 14.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023542 Fup NA 0.2109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023542 Vd NA 3.29 L/kg 1compartment NA NA Rat Human +DTXSID9023542 TK.Half.Life NA 10.66 hours 1compartment NA NA Human Human +DTXSID9023542 Css NA 0.1556 mg/L 3compartmentss NA 50% Human Human +DTXSID9023542 Css NA 1.044 mg/L 3compartmentss NA 95% Human Human +DTXSID9023542 Css NA 0.1804 mg/L PBTK NA 50% Human Human +DTXSID9023542 Css NA 0.9721 mg/L PBTK NA 95% Human Human +DTXSID9023542 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023542 Fup 0.325 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023542 Vd NA 4.06 L/kg 1compartment NA NA Rat Human DTXSID9023542 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023542 TK.Half.Life NA 2.875 hours 1compartment NA NA Rat Human -DTXSID9023542 Css NA 0.05748 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023542 Css NA 0.3086 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023542 Css NA 0.05744 mg/L PBTK NA 50% Rat Human -DTXSID9023542 Css NA 0.2573 mg/L PBTK NA 95% Rat Human -DTXSID9023546 Clint NA 38.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9023542 TK.Half.Life NA 4.581 hours 1compartment NA NA Rat Human +DTXSID9023542 Css NA 0.01798 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023542 Css NA 0.09239 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023542 Css NA 0.02145 mg/L PBTK NA 50% Rat Human +DTXSID9023542 Css NA 0.08677 mg/L PBTK NA 95% Rat Human +DTXSID9023546 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9023546 Fup 0.17 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Human Human -DTXSID9023546 Vd NA 2.37 L/kg 1compartment NA NA Human Human +DTXSID9023546 Vd NA 2.42 L/kg 1compartment NA NA Human Human DTXSID9023546 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023546 TK.Half.Life NA 2.87 hours 1compartment NA NA Human Human -DTXSID9023546 Css NA 0.0663 mg/L 3compartmentss NA 50% Human Human -DTXSID9023546 Css NA 0.5046 mg/L 3compartmentss NA 95% Human Human -DTXSID9023546 Css NA 0.05528 mg/L PBTK NA 50% Human Human -DTXSID9023546 Css NA 0.3694 mg/L PBTK NA 95% Human Human -DTXSID9023546 Clint NA 38.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9023546 TK.Half.Life NA 4.037 hours 1compartment NA NA Human Human +DTXSID9023546 Css NA 0.1036 mg/L 3compartmentss NA 50% Human Human +DTXSID9023546 Css NA 0.682 mg/L 3compartmentss NA 95% Human Human +DTXSID9023546 Css NA 0.09302 mg/L PBTK NA 50% Human Human +DTXSID9023546 Css NA 0.6131 mg/L PBTK NA 95% Human Human +DTXSID9023546 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9023546 Fup 0.17 NA NA https://doi.org/10.1016/j.ijpharm.2012.03.019 NA Rat Human -DTXSID9023546 Vd NA 2.179 L/kg 1compartment NA NA Rat Human +DTXSID9023546 Vd NA 2.217 L/kg 1compartment NA NA Rat Human DTXSID9023546 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023546 TK.Half.Life NA 1.341 hours 1compartment NA NA Rat Human -DTXSID9023546 Css NA 0.03607 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023546 Css NA 0.2128 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023546 Css NA 0.02904 mg/L PBTK NA 50% Rat Human -DTXSID9023546 Css NA 0.1561 mg/L PBTK NA 95% Rat Human -DTXSID9023548 Clint NA 25.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023548 Fup NA 0.328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023548 Vd NA 0.3991 L/kg 1compartment NA NA Human Human +DTXSID9023546 TK.Half.Life NA 1.922 hours 1compartment NA NA Rat Human +DTXSID9023546 Css NA 0.0127 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023546 Css NA 0.06333 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023546 Css NA 0.01184 mg/L PBTK NA 50% Rat Human +DTXSID9023546 Css NA 0.05904 mg/L PBTK NA 95% Rat Human +DTXSID9023548 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023548 Fup 0.367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023548 Vd NA 0.4116 L/kg 1compartment NA NA Human Human DTXSID9023548 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023548 TK.Half.Life NA 0.4909 hours 1compartment NA NA Human Human -DTXSID9023548 Css NA 0.05951 mg/L 3compartmentss NA 50% Human Human -DTXSID9023548 Css NA 0.431 mg/L 3compartmentss NA 95% Human Human -DTXSID9023548 Css NA 0.04021 mg/L PBTK NA 50% Human Human -DTXSID9023548 Css NA 0.2788 mg/L PBTK NA 95% Human Human -DTXSID9023548 Clint NA 25.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023548 Fup NA 0.328 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023548 Vd NA 0.3998 L/kg 1compartment NA NA Rat Human +DTXSID9023548 TK.Half.Life NA 7.265 hours 1compartment NA NA Human Human +DTXSID9023548 Css NA 2.049 mg/L 3compartmentss NA 50% Human Human +DTXSID9023548 Css NA 8.49 mg/L 3compartmentss NA 95% Human Human +DTXSID9023548 Css NA 1.415 mg/L PBTK NA 50% Human Human +DTXSID9023548 Css NA 5.252 mg/L PBTK NA 95% Human Human +DTXSID9023548 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023548 Fup 0.367 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023548 Vd NA 0.4147 L/kg 1compartment NA NA Rat Human DTXSID9023548 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023548 TK.Half.Life NA 0.2533 hours 1compartment NA NA Rat Human -DTXSID9023548 Css NA 0.03267 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023548 Css NA 0.1843 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023548 Css NA 0.02095 mg/L PBTK NA 50% Rat Human -DTXSID9023548 Css NA 0.1114 mg/L PBTK NA 95% Rat Human -DTXSID9023590 Clint NA 16.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9023548 TK.Half.Life NA 2.493 hours 1compartment NA NA Rat Human +DTXSID9023548 Css NA 0.1322 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023548 Css NA 0.4491 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023548 Css NA 0.08934 mg/L PBTK NA 50% Rat Human +DTXSID9023548 Css NA 0.2687 mg/L PBTK NA 95% Rat Human +DTXSID9023590 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9023590 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9023590 Vd NA 0.6515 L/kg 1compartment NA NA Human Human DTXSID9023590 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023590 TK.Half.Life NA 0.6789 hours 1compartment NA NA Human Human -DTXSID9023590 Css NA 0.0508 mg/L 3compartmentss NA 50% Human Human -DTXSID9023590 Css NA 0.4711 mg/L 3compartmentss NA 95% Human Human -DTXSID9023590 Css NA 0.0396 mg/L PBTK NA 50% Human Human -DTXSID9023590 Css NA 0.3171 mg/L PBTK NA 95% Human Human -DTXSID9023590 Clint NA 16.64 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9023590 TK.Half.Life NA 7.691 hours 1compartment NA NA Human Human +DTXSID9023590 Css NA 1.316 mg/L 3compartmentss NA 50% Human Human +DTXSID9023590 Css NA 8.169 mg/L 3compartmentss NA 95% Human Human +DTXSID9023590 Css NA 1.026 mg/L PBTK NA 50% Human Human +DTXSID9023590 Css NA 5.119 mg/L PBTK NA 95% Human Human +DTXSID9023590 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9023590 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9023590 Vd NA 0.6587 L/kg 1compartment NA NA Rat Human DTXSID9023590 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023590 TK.Half.Life NA 0.3517 hours 1compartment NA NA Rat Human -DTXSID9023590 Css NA 0.0264 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023590 Css NA 0.214 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023590 Css NA 0.01969 mg/L PBTK NA 50% Rat Human -DTXSID9023590 Css NA 0.1327 mg/L PBTK NA 95% Rat Human +DTXSID9023590 TK.Half.Life NA 2.643 hours 1compartment NA NA Rat Human +DTXSID9023590 Css NA 0.08055 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023590 Css NA 0.4835 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023590 Css NA 0.06247 mg/L PBTK NA 50% Rat Human +DTXSID9023590 Css NA 0.2928 mg/L PBTK NA 95% Rat Human +DTXSID9023592 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023592 Fup 0.734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023592 Vd NA 0.5974 L/kg 1compartment NA NA Human Human +DTXSID9023592 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023592 TK.Half.Life NA 5.267 hours 1compartment NA NA Human Human +DTXSID9023592 Css NA 0.9438 mg/L 3compartmentss NA 50% Human Human +DTXSID9023592 Css NA 5.806 mg/L 3compartmentss NA 95% Human Human +DTXSID9023592 Css NA 0.742 mg/L PBTK NA 50% Human Human +DTXSID9023592 Css NA 3.608 mg/L PBTK NA 95% Human Human +DTXSID9023592 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023592 Fup 0.734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023592 Vd NA 0.6335 L/kg 1compartment NA NA Rat Human +DTXSID9023592 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9023592 TK.Half.Life NA 1.903 hours 1compartment NA NA Rat Human +DTXSID9023592 Css NA 0.02421 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023592 Css NA 0.1851 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023592 Css NA 0.01858 mg/L PBTK NA 50% Rat Human +DTXSID9023592 Css NA 0.1161 mg/L PBTK NA 95% Rat Human DTXSID9023621 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9023621 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023621 Vd NA 0.1643 L/kg 1compartment NA NA Human Human -DTXSID9023621 Days.Css NA 40 Days PBTK NA NA Human Human -DTXSID9023621 TK.Half.Life NA 171.4 hours 1compartment NA NA Human Human -DTXSID9023621 Css NA 181.7 mg/L 3compartmentss NA 50% Human Human -DTXSID9023621 Css NA 1094 mg/L 3compartmentss NA 95% Human Human -DTXSID9023621 Css NA 105.9 mg/L PBTK NA 50% Human Human -DTXSID9023621 Css NA 641 mg/L PBTK NA 95% Human Human +DTXSID9023621 Vd NA 0.1619 L/kg 1compartment NA NA Human Human +DTXSID9023621 Days.Css NA 39 Days PBTK NA NA Human Human +DTXSID9023621 TK.Half.Life NA 168.9 hours 1compartment NA NA Human Human +DTXSID9023621 Css NA 154.2 mg/L 3compartmentss NA 50% Human Human +DTXSID9023621 Css NA 949.9 mg/L 3compartmentss NA 95% Human Human +DTXSID9023621 Css NA 89.74 mg/L PBTK NA 50% Human Human +DTXSID9023621 Css NA 546.2 mg/L PBTK NA 95% Human Human DTXSID9023621 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9023621 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023621 Vd NA 0.1628 L/kg 1compartment NA NA Rat Human +DTXSID9023621 Vd NA 0.1607 L/kg 1compartment NA NA Rat Human DTXSID9023621 Days.Css NA 11 Days PBTK NA NA Rat Human -DTXSID9023621 TK.Half.Life NA 57.91 hours 1compartment NA NA Rat Human -DTXSID9023621 Css NA 51.84 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023621 Css NA 277.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023621 Css NA 28.08 mg/L PBTK NA 50% Rat Human -DTXSID9023621 Css NA 149.8 mg/L PBTK NA 95% Rat Human -DTXSID9023623 Clint NA 2.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023623 Fup NA 0.106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023623 Vd NA 0.2839 L/kg 1compartment NA NA Human Human -DTXSID9023623 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023623 TK.Half.Life NA 3.312 hours 1compartment NA NA Human Human -DTXSID9023623 Css NA 1.826 mg/L 3compartmentss NA 50% Human Human -DTXSID9023623 Css NA 10.52 mg/L 3compartmentss NA 95% Human Human -DTXSID9023623 Css NA 1.129 mg/L PBTK NA 50% Human Human -DTXSID9023623 Css NA 6.214 mg/L PBTK NA 95% Human Human -DTXSID9023623 Clint NA 2.66 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023623 Fup NA 0.106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023623 Vd NA 0.2849 L/kg 1compartment NA NA Rat Human +DTXSID9023621 TK.Half.Life NA 57.14 hours 1compartment NA NA Rat Human +DTXSID9023621 Css NA 2.96 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023621 Css NA 23.22 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023621 Css NA 1.621 mg/L PBTK NA 50% Rat Human +DTXSID9023621 Css NA 12.87 mg/L PBTK NA 95% Rat Human +DTXSID9023623 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023623 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023623 Vd NA 0.2747 L/kg 1compartment NA NA Human Human +DTXSID9023623 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9023623 TK.Half.Life NA 13.56 hours 1compartment NA NA Human Human +DTXSID9023623 Css NA 4.012 mg/L 3compartmentss NA 50% Human Human +DTXSID9023623 Css NA 19.6 mg/L 3compartmentss NA 95% Human Human +DTXSID9023623 Css NA 2.488 mg/L PBTK NA 50% Human Human +DTXSID9023623 Css NA 11.58 mg/L PBTK NA 95% Human Human +DTXSID9023623 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023623 Fup 0.131 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023623 Vd NA 0.2833 L/kg 1compartment NA NA Rat Human DTXSID9023623 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023623 TK.Half.Life NA 1.91 hours 1compartment NA NA Rat Human -DTXSID9023623 Css NA 0.8796 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023623 Css NA 3.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023623 Css NA 0.5108 mg/L PBTK NA 50% Rat Human -DTXSID9023623 Css NA 2.184 mg/L PBTK NA 95% Rat Human -DTXSID9023629 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023629 Fup NA 0.0425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023629 Vd NA 1.981 L/kg 1compartment NA NA Human Human +DTXSID9023623 TK.Half.Life NA 4.767 hours 1compartment NA NA Rat Human +DTXSID9023623 Css NA 0.02185 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023623 Css NA 0.1075 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023623 Css NA 0.01278 mg/L PBTK NA 50% Rat Human +DTXSID9023623 Css NA 0.06012 mg/L PBTK NA 95% Rat Human +DTXSID9023629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023629 Fup 0.0741 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023629 Vd NA 2.462 L/kg 1compartment NA NA Human Human DTXSID9023629 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023629 TK.Half.Life NA 7.451 hours 1compartment NA NA Human Human -DTXSID9023629 Css NA 0.4799 mg/L 3compartmentss NA 50% Human Human -DTXSID9023629 Css NA 3.923 mg/L 3compartmentss NA 95% Human Human -DTXSID9023629 Css NA 0.3178 mg/L PBTK NA 50% Human Human -DTXSID9023629 Css NA 2.457 mg/L PBTK NA 95% Human Human -DTXSID9023629 Clint NA 36.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023629 Fup NA 0.0425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023629 Vd NA 1.535 L/kg 1compartment NA NA Rat Human +DTXSID9023629 TK.Half.Life NA 13.03 hours 1compartment NA NA Human Human +DTXSID9023629 Css NA 0.6254 mg/L 3compartmentss NA 50% Human Human +DTXSID9023629 Css NA 4.051 mg/L 3compartmentss NA 95% Human Human +DTXSID9023629 Css NA 0.4234 mg/L PBTK NA 50% Human Human +DTXSID9023629 Css NA 2.663 mg/L PBTK NA 95% Human Human +DTXSID9023629 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023629 Fup 0.0741 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023629 Vd NA 1.85 L/kg 1compartment NA NA Rat Human DTXSID9023629 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023629 TK.Half.Life NA 2.686 hours 1compartment NA NA Rat Human -DTXSID9023629 Css NA 0.2709 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023629 Css NA 1.798 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023629 Css NA 0.1699 mg/L PBTK NA 50% Rat Human -DTXSID9023629 Css NA 1.065 mg/L PBTK NA 95% Rat Human -DTXSID9023673 Clint NA 69.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023673 Fup NA 0.0971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023673 Vd NA 2.421 L/kg 1compartment NA NA Human Human -DTXSID9023673 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023673 TK.Half.Life NA 4.281 hours 1compartment NA NA Human Human -DTXSID9023673 Css NA 0.1397 mg/L 3compartmentss NA 50% Human Human -DTXSID9023673 Css NA 0.9996 mg/L 3compartmentss NA 95% Human Human -DTXSID9023673 Css NA 0.09763 mg/L PBTK NA 50% Human Human -DTXSID9023673 Css NA 0.6626 mg/L PBTK NA 95% Human Human -DTXSID9023673 Clint NA 69.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023673 Fup NA 0.0971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023673 Vd NA 1.872 L/kg 1compartment NA NA Rat Human -DTXSID9023673 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023673 TK.Half.Life NA 1.347 hours 1compartment NA NA Rat Human -DTXSID9023673 Css NA 0.078 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023673 Css NA 0.4413 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023673 Css NA 0.05185 mg/L PBTK NA 50% Rat Human -DTXSID9023673 Css NA 0.2878 mg/L PBTK NA 95% Rat Human -DTXSID9023677 Clint NA 15.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023677 Fup NA 0.0421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023677 Vd NA 0.4166 L/kg 1compartment NA NA Human Human +DTXSID9023629 TK.Half.Life NA 3.44 hours 1compartment NA NA Rat Human +DTXSID9023629 Css NA 0.08045 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023629 Css NA 0.4373 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023629 Css NA 0.05373 mg/L PBTK NA 50% Rat Human +DTXSID9023629 Css NA 0.2843 mg/L PBTK NA 95% Rat Human +DTXSID9023671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023671 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023671 Vd NA 2.835 L/kg 1compartment NA NA Human Human +DTXSID9023671 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023671 TK.Half.Life NA 7.646 hours 1compartment NA NA Human Human +DTXSID9023671 Css NA 0.2219 mg/L 3compartmentss NA 50% Human Human +DTXSID9023671 Css NA 1.431 mg/L 3compartmentss NA 95% Human Human +DTXSID9023671 Css NA 0.1685 mg/L PBTK NA 50% Human Human +DTXSID9023671 Css NA 1.026 mg/L PBTK NA 95% Human Human +DTXSID9023671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023671 Fup 0.215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023671 Vd NA 2.244 L/kg 1compartment NA NA Rat Human +DTXSID9023671 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9023671 TK.Half.Life NA 2.109 hours 1compartment NA NA Rat Human +DTXSID9023671 Css NA 0.02787 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023671 Css NA 0.1388 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023671 Css NA 0.02133 mg/L PBTK NA 50% Rat Human +DTXSID9023671 Css NA 0.1036 mg/L PBTK NA 95% Rat Human +DTXSID9023673 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023673 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023673 Vd NA 3.008 L/kg 1compartment NA NA Human Human +DTXSID9023673 Days.Css NA 13 Days PBTK NA NA Human Human +DTXSID9023673 TK.Half.Life NA 84.04 hours 1compartment NA NA Human Human +DTXSID9023673 Css NA 3.335 mg/L 3compartmentss NA 50% Human Human +DTXSID9023673 Css NA 19.01 mg/L 3compartmentss NA 95% Human Human +DTXSID9023673 Css NA 2.327 mg/L PBTK NA 50% Human Human +DTXSID9023673 Css NA 12.83 mg/L PBTK NA 95% Human Human +DTXSID9023673 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023673 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023673 Vd NA 2.26 L/kg 1compartment NA NA Rat Human +DTXSID9023673 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID9023673 TK.Half.Life NA 12.9 hours 1compartment NA NA Rat Human +DTXSID9023673 Css NA 0.4192 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023673 Css NA 1.803 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023673 Css NA 0.2901 mg/L PBTK NA 50% Rat Human +DTXSID9023673 Css NA 1.223 mg/L PBTK NA 95% Rat Human +DTXSID9023677 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023677 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023677 Vd NA 0.8947 L/kg 1compartment NA NA Human Human DTXSID9023677 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023677 TK.Half.Life NA 2.712 hours 1compartment NA NA Human Human -DTXSID9023677 Css NA 1.116 mg/L 3compartmentss NA 50% Human Human -DTXSID9023677 Css NA 8.911 mg/L 3compartmentss NA 95% Human Human -DTXSID9023677 Css NA 0.6703 mg/L PBTK NA 50% Human Human -DTXSID9023677 Css NA 5.2 mg/L PBTK NA 95% Human Human -DTXSID9023677 Clint NA 15.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023677 Fup NA 0.0421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023677 Vd NA 0.3711 L/kg 1compartment NA NA Rat Human +DTXSID9023677 TK.Half.Life NA 1.587 hours 1compartment NA NA Human Human +DTXSID9023677 Css NA 0.1224 mg/L 3compartmentss NA 50% Human Human +DTXSID9023677 Css NA 0.8775 mg/L 3compartmentss NA 95% Human Human +DTXSID9023677 Css NA 0.08516 mg/L PBTK NA 50% Human Human +DTXSID9023677 Css NA 0.5744 mg/L PBTK NA 95% Human Human +DTXSID9023677 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023677 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023677 Vd NA 0.8003 L/kg 1compartment NA NA Rat Human DTXSID9023677 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023677 TK.Half.Life NA 1.534 hours 1compartment NA NA Rat Human -DTXSID9023677 Css NA 0.6247 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023677 Css NA 3.761 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023677 Css NA 0.3518 mg/L PBTK NA 50% Rat Human -DTXSID9023677 Css NA 2.086 mg/L PBTK NA 95% Rat Human -DTXSID9023679 Clint NA 28.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9023677 TK.Half.Life NA 0.7861 hours 1compartment NA NA Rat Human +DTXSID9023677 Css NA 0.01536 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023677 Css NA 0.08256 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023677 Css NA 0.01056 mg/L PBTK NA 50% Rat Human +DTXSID9023677 Css NA 0.05258 mg/L PBTK NA 95% Rat Human +DTXSID9023679 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9023679 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9023679 Vd NA 3.005 L/kg 1compartment NA NA Human Human +DTXSID9023679 Vd NA 2.194 L/kg 1compartment NA NA Human Human DTXSID9023679 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023679 TK.Half.Life NA 2.207 hours 1compartment NA NA Human Human -DTXSID9023679 Css NA 0.02384 mg/L 3compartmentss NA 50% Human Human -DTXSID9023679 Css NA 0.2507 mg/L 3compartmentss NA 95% Human Human -DTXSID9023679 Css NA 0.02465 mg/L PBTK NA 50% Human Human -DTXSID9023679 Css NA 0.2016 mg/L PBTK NA 95% Human Human -DTXSID9023679 Clint NA 28.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9023679 TK.Half.Life NA 2.814 hours 1compartment NA NA Human Human +DTXSID9023679 Css NA 0.08307 mg/L 3compartmentss NA 50% Human Human +DTXSID9023679 Css NA 0.7729 mg/L 3compartmentss NA 95% Human Human +DTXSID9023679 Css NA 0.08316 mg/L PBTK NA 50% Human Human +DTXSID9023679 Css NA 0.5782 mg/L PBTK NA 95% Human Human +DTXSID9023679 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9023679 Fup 0.7 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9023679 Vd NA 2.751 L/kg 1compartment NA NA Rat Human +DTXSID9023679 Vd NA 2.131 L/kg 1compartment NA NA Rat Human DTXSID9023679 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023679 TK.Half.Life NA 0.9119 hours 1compartment NA NA Rat Human -DTXSID9023679 Css NA 0.01223 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023679 Css NA 0.1103 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023679 Css NA 0.01272 mg/L PBTK NA 50% Rat Human -DTXSID9023679 Css NA 0.08871 mg/L PBTK NA 95% Rat Human +DTXSID9023679 TK.Half.Life NA 1.438 hours 1compartment NA NA Rat Human +DTXSID9023679 Css NA 0.008916 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023679 Css NA 0.07566 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023679 Css NA 0.009214 mg/L PBTK NA 50% Rat Human +DTXSID9023679 Css NA 0.0544 mg/L PBTK NA 95% Rat Human DTXSID9023702 Clint NA 117.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9023702 Fup NA 0.9654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023702 Vd NA 1.866 L/kg 1compartment NA NA Human Human +DTXSID9023702 Vd NA 1.265 L/kg 1compartment NA NA Human Human DTXSID9023702 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023702 TK.Half.Life NA 0.8976 hours 1compartment NA NA Human Human -DTXSID9023702 Css NA 0.004043 mg/L 3compartmentss NA 50% Human Human -DTXSID9023702 Css NA 0.0491 mg/L 3compartmentss NA 95% Human Human -DTXSID9023702 Css NA 0.004015 mg/L PBTK NA 50% Human Human -DTXSID9023702 Css NA 0.03966 mg/L PBTK NA 95% Human Human +DTXSID9023702 TK.Half.Life NA 0.6665 hours 1compartment NA NA Human Human +DTXSID9023702 Css NA 0.001776 mg/L 3compartmentss NA 50% Human Human +DTXSID9023702 Css NA 0.03794 mg/L 3compartmentss NA 95% Human Human +DTXSID9023702 Css NA 0.001624 mg/L PBTK NA 50% Human Human +DTXSID9023702 Css NA 0.02839 mg/L PBTK NA 95% Human Human DTXSID9023702 Clint NA 117.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9023702 Fup NA 0.9654 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023702 Vd NA 1.878 L/kg 1compartment NA NA Rat Human +DTXSID9023702 Vd NA 1.299 L/kg 1compartment NA NA Rat Human DTXSID9023702 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023702 TK.Half.Life NA 0.4023 hours 1compartment NA NA Rat Human -DTXSID9023702 Css NA 0.002095 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023702 Css NA 0.02247 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023702 Css NA 0.002088 mg/L PBTK NA 50% Rat Human -DTXSID9023702 Css NA 0.01774 mg/L PBTK NA 95% Rat Human -DTXSID9023706 Clint NA 0.5075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023706 Fup NA 0.0924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023706 Vd NA 0.3113 L/kg 1compartment NA NA Human Human -DTXSID9023706 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9023706 TK.Half.Life NA 11.91 hours 1compartment NA NA Human Human -DTXSID9023706 Css NA 5.896 mg/L 3compartmentss NA 50% Human Human -DTXSID9023706 Css NA 29.13 mg/L 3compartmentss NA 95% Human Human -DTXSID9023706 Css NA 3.705 mg/L PBTK NA 50% Human Human -DTXSID9023706 Css NA 17.18 mg/L PBTK NA 95% Human Human -DTXSID9023706 Clint NA 0.5075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023706 Fup NA 0.0924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023706 Vd NA 0.306 L/kg 1compartment NA NA Rat Human +DTXSID9023702 TK.Half.Life NA 0.3031 hours 1compartment NA NA Rat Human +DTXSID9023702 Css NA 6.112e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023702 Css NA 0.001602 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023702 Css NA 5.458e-05 mg/L PBTK NA 50% Rat Human +DTXSID9023702 Css NA 0.001224 mg/L PBTK NA 95% Rat Human +DTXSID9023706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023706 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023706 Vd NA 2.048 L/kg 1compartment NA NA Human Human +DTXSID9023706 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023706 TK.Half.Life NA 5.94 hours 1compartment NA NA Human Human +DTXSID9023706 Css NA 0.2924 mg/L 3compartmentss NA 50% Human Human +DTXSID9023706 Css NA 2.147 mg/L 3compartmentss NA 95% Human Human +DTXSID9023706 Css NA 0.2024 mg/L PBTK NA 50% Human Human +DTXSID9023706 Css NA 1.368 mg/L PBTK NA 95% Human Human +DTXSID9023706 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023706 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023706 Vd NA 1.557 L/kg 1compartment NA NA Rat Human DTXSID9023706 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023706 TK.Half.Life NA 5.196 hours 1compartment NA NA Rat Human -DTXSID9023706 Css NA 2.196 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023706 Css NA 9.101 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023706 Css NA 1.289 mg/L PBTK NA 50% Rat Human -DTXSID9023706 Css NA 5.01 mg/L PBTK NA 95% Rat Human +DTXSID9023706 TK.Half.Life NA 1.953 hours 1compartment NA NA Rat Human +DTXSID9023706 Css NA 0.03842 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023706 Css NA 0.2077 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023706 Css NA 0.02604 mg/L PBTK NA 50% Rat Human +DTXSID9023706 Css NA 0.1354 mg/L PBTK NA 95% Rat Human DTXSID9023752 Clint 2.298 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID9023752 Fup 0.07 NA NA https://doi.org/10.1124/dmd.117.077040 NA Human Human -DTXSID9023752 Vd NA 0.2588 L/kg 1compartment NA NA Human Human +DTXSID9023752 Vd NA 0.3139 L/kg 1compartment NA NA Human Human DTXSID9023752 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023752 TK.Half.Life NA 5.127 hours 1compartment NA NA Human Human -DTXSID9023752 Css NA 3.314 mg/L 3compartmentss NA 50% Human Human -DTXSID9023752 Css NA 18.07 mg/L 3compartmentss NA 95% Human Human -DTXSID9023752 Css NA 2 mg/L PBTK NA 50% Human Human -DTXSID9023752 Css NA 10.61 mg/L PBTK NA 95% Human Human +DTXSID9023752 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human +DTXSID9023752 Css NA 3.196 mg/L 3compartmentss NA 50% Human Human +DTXSID9023752 Css NA 16.95 mg/L 3compartmentss NA 95% Human Human +DTXSID9023752 Css NA 1.938 mg/L PBTK NA 50% Human Human +DTXSID9023752 Css NA 9.97 mg/L PBTK NA 95% Human Human DTXSID9023752 Clint 2.298 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID9023752 Fup 0.07 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human -DTXSID9023752 Vd NA 0.2553 L/kg 1compartment NA NA Rat Human +DTXSID9023752 Vd NA 0.2944 L/kg 1compartment NA NA Rat Human DTXSID9023752 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023752 TK.Half.Life NA 2.865 hours 1compartment NA NA Rat Human -DTXSID9023752 Css NA 1.583 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023752 Css NA 6.438 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023752 Css NA 0.8918 mg/L PBTK NA 50% Rat Human -DTXSID9023752 Css NA 3.53 mg/L PBTK NA 95% Rat Human -DTXSID9023756 Clint NA 57.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023756 Fup NA 0.0313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023756 Vd NA 1.326 L/kg 1compartment NA NA Human Human +DTXSID9023752 TK.Half.Life NA 3.28 hours 1compartment NA NA Rat Human +DTXSID9023752 Css NA 0.3501 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023752 Css NA 1.445 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023752 Css NA 0.2062 mg/L PBTK NA 50% Rat Human +DTXSID9023752 Css NA 0.8218 mg/L PBTK NA 95% Rat Human +DTXSID9023754 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023754 Fup 0.0572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023754 Vd NA 0.2832 L/kg 1compartment NA NA Human Human +DTXSID9023754 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9023754 TK.Half.Life NA 5.523 hours 1compartment NA NA Human Human +DTXSID9023754 Css NA 3.248 mg/L 3compartmentss NA 50% Human Human +DTXSID9023754 Css NA 19.35 mg/L 3compartmentss NA 95% Human Human +DTXSID9023754 Css NA 1.976 mg/L PBTK NA 50% Human Human +DTXSID9023754 Css NA 11.44 mg/L PBTK NA 95% Human Human +DTXSID9023754 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023754 Fup 0.0572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023754 Vd NA 0.2717 L/kg 1compartment NA NA Rat Human +DTXSID9023754 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9023754 TK.Half.Life NA 3.11 hours 1compartment NA NA Rat Human +DTXSID9023754 Css NA 0.3654 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023754 Css NA 1.734 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023754 Css NA 0.216 mg/L PBTK NA 50% Rat Human +DTXSID9023754 Css NA 0.9866 mg/L PBTK NA 95% Rat Human +DTXSID9023756 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023756 Fup 0.0609 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023756 Vd NA 2.209 L/kg 1compartment NA NA Human Human DTXSID9023756 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023756 TK.Half.Life NA 2.511 hours 1compartment NA NA Human Human -DTXSID9023756 Css NA 0.1809 mg/L 3compartmentss NA 50% Human Human -DTXSID9023756 Css NA 2.079 mg/L 3compartmentss NA 95% Human Human -DTXSID9023756 Css NA 0.1249 mg/L PBTK NA 50% Human Human -DTXSID9023756 Css NA 1.305 mg/L PBTK NA 95% Human Human -DTXSID9023756 Clint NA 57.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023756 Fup NA 0.0313 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023756 Vd NA 1.284 L/kg 1compartment NA NA Rat Human +DTXSID9023756 TK.Half.Life NA 11.56 hours 1compartment NA NA Human Human +DTXSID9023756 Css NA 0.6384 mg/L 3compartmentss NA 50% Human Human +DTXSID9023756 Css NA 5.291 mg/L 3compartmentss NA 95% Human Human +DTXSID9023756 Css NA 0.5065 mg/L PBTK NA 50% Human Human +DTXSID9023756 Css NA 3.683 mg/L PBTK NA 95% Human Human +DTXSID9023756 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023756 Fup 0.0609 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023756 Vd NA 2.155 L/kg 1compartment NA NA Rat Human DTXSID9023756 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023756 TK.Half.Life NA 1.414 hours 1compartment NA NA Rat Human -DTXSID9023756 Css NA 0.1054 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023756 Css NA 0.9127 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023756 Css NA 0.0686 mg/L PBTK NA 50% Rat Human -DTXSID9023756 Css NA 0.5357 mg/L PBTK NA 95% Rat Human -DTXSID9023833 Clint NA 0.002095 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023833 Fup NA 0.5478 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023833 Vd NA 1.125 L/kg 1compartment NA NA Human Human -DTXSID9023833 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9023833 TK.Half.Life NA 14.25 hours 1compartment NA NA Human Human -DTXSID9023833 Css NA 1.326 mg/L 3compartmentss NA 50% Human Human -DTXSID9023833 Css NA 8.09 mg/L 3compartmentss NA 95% Human Human -DTXSID9023833 Css NA 1.11 mg/L PBTK NA 50% Human Human -DTXSID9023833 Css NA 5.268 mg/L PBTK NA 95% Human Human -DTXSID9023833 Clint NA 0.002095 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023833 Fup NA 0.5478 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023833 Vd NA 1.014 L/kg 1compartment NA NA Rat Human -DTXSID9023833 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023833 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human -DTXSID9023833 Css NA 0.3509 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023833 Css NA 2.156 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023833 Css NA 0.2838 mg/L PBTK NA 50% Rat Human -DTXSID9023833 Css NA 1.292 mg/L PBTK NA 95% Rat Human -DTXSID9023835 Clint NA 956.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023835 Fup NA 0.052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023835 Vd NA 3.065 L/kg 1compartment NA NA Human Human +DTXSID9023756 TK.Half.Life NA 6.931 hours 1compartment NA NA Rat Human +DTXSID9023756 Css NA 0.07961 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023756 Css NA 0.5381 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023756 Css NA 0.06352 mg/L PBTK NA 50% Rat Human +DTXSID9023756 Css NA 0.358 mg/L PBTK NA 95% Rat Human +DTXSID90238097 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90238097 Fup 0.46 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90238097 Vd NA 0.7021 L/kg 1compartment NA NA Human Human +DTXSID90238097 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90238097 TK.Half.Life NA 0.7428 hours 1compartment NA NA Human Human +DTXSID90238097 Css NA 0.04302 mg/L 3compartmentss NA 50% Human Human +DTXSID90238097 Css NA 0.3533 mg/L 3compartmentss NA 95% Human Human +DTXSID90238097 Css NA 0.0322 mg/L PBTK NA 50% Human Human +DTXSID90238097 Css NA 0.2376 mg/L PBTK NA 95% Human Human +DTXSID90238097 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90238097 Fup 0.46 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90238097 Vd NA 0.6564 L/kg 1compartment NA NA Rat Human +DTXSID90238097 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90238097 TK.Half.Life NA 0.3506 hours 1compartment NA NA Rat Human +DTXSID90238097 Css NA 0.005267 mg/L 3compartmentss NA 50% Rat Human +DTXSID90238097 Css NA 0.03503 mg/L 3compartmentss NA 95% Rat Human +DTXSID90238097 Css NA 0.003945 mg/L PBTK NA 50% Rat Human +DTXSID90238097 Css NA 0.02364 mg/L PBTK NA 95% Rat Human +DTXSID9023835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023835 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023835 Vd NA 0.5375 L/kg 1compartment NA NA Human Human DTXSID9023835 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9023835 TK.Half.Life NA 2.781 hours 1compartment NA NA Human Human -DTXSID9023835 Css NA 0.01587 mg/L 3compartmentss NA 50% Human Human -DTXSID9023835 Css NA 0.1029 mg/L 3compartmentss NA 95% Human Human -DTXSID9023835 Css NA 0.01128 mg/L PBTK NA 50% Human Human -DTXSID9023835 Css NA 0.07082 mg/L PBTK NA 95% Human Human -DTXSID9023835 Clint NA 956.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023835 Fup NA 0.052 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023835 Vd NA 2.369 L/kg 1compartment NA NA Rat Human +DTXSID9023835 TK.Half.Life NA 1.146 hours 1compartment NA NA Human Human +DTXSID9023835 Css NA 0.173 mg/L 3compartmentss NA 50% Human Human +DTXSID9023835 Css NA 1.5 mg/L 3compartmentss NA 95% Human Human +DTXSID9023835 Css NA 0.1118 mg/L PBTK NA 50% Human Human +DTXSID9023835 Css NA 0.8965 mg/L PBTK NA 95% Human Human +DTXSID9023835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023835 Fup 0.133 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023835 Vd NA 0.5376 L/kg 1compartment NA NA Rat Human DTXSID9023835 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023835 TK.Half.Life NA 0.8842 hours 1compartment NA NA Rat Human -DTXSID9023835 Css NA 0.00895 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023835 Css NA 0.05023 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023835 Css NA 0.006113 mg/L PBTK NA 50% Rat Human -DTXSID9023835 Css NA 0.03353 mg/L PBTK NA 95% Rat Human -DTXSID9023837 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023837 Fup NA 0.4584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023837 Vd NA 1.036 L/kg 1compartment NA NA Human Human -DTXSID9023837 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9023837 TK.Half.Life NA 14.64 hours 1compartment NA NA Human Human -DTXSID9023837 Css NA 1.256 mg/L 3compartmentss NA 50% Human Human -DTXSID9023837 Css NA 6.757 mg/L 3compartmentss NA 95% Human Human -DTXSID9023837 Css NA 1.194 mg/L PBTK NA 50% Human Human -DTXSID9023837 Css NA 4.751 mg/L PBTK NA 95% Human Human -DTXSID9023837 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023837 Fup NA 0.4584 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023837 Vd NA 1.037 L/kg 1compartment NA NA Rat Human -DTXSID9023837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9023837 TK.Half.Life NA 4.987 hours 1compartment NA NA Rat Human -DTXSID9023837 Css NA 0.3387 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023837 Css NA 1.583 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023837 Css NA 0.3103 mg/L PBTK NA 50% Rat Human -DTXSID9023837 Css NA 1.034 mg/L PBTK NA 95% Rat Human +DTXSID9023835 TK.Half.Life NA 0.6646 hours 1compartment NA NA Rat Human +DTXSID9023835 Css NA 0.008503 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023835 Css NA 0.07935 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023835 Css NA 0.005382 mg/L PBTK NA 50% Rat Human +DTXSID9023835 Css NA 0.04709 mg/L PBTK NA 95% Rat Human DTXSID9023881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9023881 Fup NA 0.0425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023881 Vd NA 1.457 L/kg 1compartment NA NA Human Human -DTXSID9023881 Days.Css NA 72 Days PBTK NA NA Human Human -DTXSID9023881 TK.Half.Life NA 308.5 hours 1compartment NA NA Human Human -DTXSID9023881 Css NA 32.72 mg/L 3compartmentss NA 50% Human Human -DTXSID9023881 Css NA 161.3 mg/L 3compartmentss NA 95% Human Human -DTXSID9023881 Css NA 20.78 mg/L PBTK NA 50% Human Human -DTXSID9023881 Css NA 95.52 mg/L PBTK NA 95% Human Human +DTXSID9023881 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023881 Vd NA 1.478 L/kg 1compartment NA NA Human Human +DTXSID9023881 Days.Css NA 71 Days PBTK NA NA Human Human +DTXSID9023881 TK.Half.Life NA 305.8 hours 1compartment NA NA Human Human +DTXSID9023881 Css NA 30.26 mg/L 3compartmentss NA 50% Human Human +DTXSID9023881 Css NA 143.2 mg/L 3compartmentss NA 95% Human Human +DTXSID9023881 Css NA 19.31 mg/L PBTK NA 50% Human Human +DTXSID9023881 Css NA 83.6 mg/L PBTK NA 95% Human Human DTXSID9023881 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9023881 Fup NA 0.0425 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023881 Vd NA 1.093 L/kg 1compartment NA NA Rat Human +DTXSID9023881 Fup 0.0439 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023881 Vd NA 1.109 L/kg 1compartment NA NA Rat Human DTXSID9023881 Days.Css NA 16 Days PBTK NA NA Rat Human -DTXSID9023881 TK.Half.Life NA 62 hours 1compartment NA NA Rat Human -DTXSID9023881 Css NA 9.305 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023881 Css NA 37.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023881 Css NA 5.538 mg/L PBTK NA 50% Rat Human -DTXSID9023881 Css NA 20.8 mg/L PBTK NA 95% Rat Human -DTXSID9023883 Clint NA 15.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023883 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023883 Vd NA 3.127 L/kg 1compartment NA NA Human Human -DTXSID9023883 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID9023883 TK.Half.Life NA 128.1 hours 1compartment NA NA Human Human -DTXSID9023883 Css NA 4.796 mg/L 3compartmentss NA 50% Human Human -DTXSID9023883 Css NA 28.11 mg/L 3compartmentss NA 95% Human Human -DTXSID9023883 Css NA 3.328 mg/L PBTK NA 50% Human Human -DTXSID9023883 Css NA 19.31 mg/L PBTK NA 95% Human Human -DTXSID9023883 Clint NA 15.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023883 Fup NA 0.0265 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023883 Vd NA 2.343 L/kg 1compartment NA NA Rat Human -DTXSID9023883 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID9023883 TK.Half.Life NA 16.86 hours 1compartment NA NA Rat Human -DTXSID9023883 Css NA 2.764 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023883 Css NA 11.46 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023883 Css NA 1.828 mg/L PBTK NA 50% Rat Human -DTXSID9023883 Css NA 7.575 mg/L PBTK NA 95% Rat Human +DTXSID9023881 TK.Half.Life NA 61.07 hours 1compartment NA NA Rat Human +DTXSID9023881 Css NA 1.965 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023881 Css NA 7.62 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023881 Css NA 1.217 mg/L PBTK NA 50% Rat Human +DTXSID9023881 Css NA 4.391 mg/L PBTK NA 95% Rat Human DTXSID9023889 Clint 35.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9023889 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9023889 Vd NA 2.505 L/kg 1compartment NA NA Human Human +DTXSID9023889 Fup 0.00912 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9023889 Vd NA 2.16 L/kg 1compartment NA NA Human Human DTXSID9023889 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9023889 TK.Half.Life NA 21.85 hours 1compartment NA NA Human Human -DTXSID9023889 Css NA 1.191 mg/L 3compartmentss NA 50% Human Human -DTXSID9023889 Css NA 9.05 mg/L 3compartmentss NA 95% Human Human -DTXSID9023889 Css NA 0.7872 mg/L PBTK NA 50% Human Human -DTXSID9023889 Css NA 5.787 mg/L PBTK NA 95% Human Human +DTXSID9023889 TK.Half.Life NA 23.28 hours 1compartment NA NA Human Human +DTXSID9023889 Css NA 1.566 mg/L 3compartmentss NA 50% Human Human +DTXSID9023889 Css NA 12.74 mg/L 3compartmentss NA 95% Human Human +DTXSID9023889 Css NA 1.006 mg/L PBTK NA 50% Human Human +DTXSID9023889 Css NA 7.954 mg/L PBTK NA 95% Human Human DTXSID9023889 Clint 35.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9023889 Fup NA 0.017 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9023889 Vd NA 1.868 L/kg 1compartment NA NA Rat Human +DTXSID9023889 Fup 0.00912 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9023889 Vd NA 1.602 L/kg 1compartment NA NA Rat Human DTXSID9023889 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9023889 TK.Half.Life NA 5.458 hours 1compartment NA NA Rat Human -DTXSID9023889 Css NA 0.6712 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023889 Css NA 3.879 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023889 Css NA 0.4184 mg/L PBTK NA 50% Rat Human -DTXSID9023889 Css NA 2.373 mg/L PBTK NA 95% Rat Human +DTXSID9023889 TK.Half.Life NA 6.962 hours 1compartment NA NA Rat Human +DTXSID9023889 Css NA 0.2049 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023889 Css NA 1.4 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023889 Css NA 0.1282 mg/L PBTK NA 50% Rat Human +DTXSID9023889 Css NA 0.8458 mg/L PBTK NA 95% Rat Human DTXSID9023914 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9023914 Fup 0.8457 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9023914 Vd NA 1.097 L/kg 1compartment NA NA Human Human DTXSID9023914 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9023914 TK.Half.Life NA 8.439 hours 1compartment NA NA Human Human -DTXSID9023914 Css NA 0.8898 mg/L 3compartmentss NA 50% Human Human -DTXSID9023914 Css NA 5.884 mg/L 3compartmentss NA 95% Human Human -DTXSID9023914 Css NA 0.7832 mg/L PBTK NA 50% Human Human -DTXSID9023914 Css NA 3.862 mg/L PBTK NA 95% Human Human +DTXSID9023914 Css NA 0.8651 mg/L 3compartmentss NA 50% Human Human +DTXSID9023914 Css NA 5.698 mg/L 3compartmentss NA 95% Human Human +DTXSID9023914 Css NA 0.7632 mg/L PBTK NA 50% Human Human +DTXSID9023914 Css NA 3.759 mg/L PBTK NA 95% Human Human DTXSID9023914 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9023914 Fup 0.8457 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9023914 Vd NA 1.108 L/kg 1compartment NA NA Rat Human DTXSID9023914 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9023914 TK.Half.Life NA 2.893 hours 1compartment NA NA Rat Human -DTXSID9023914 Css NA 0.229 mg/L 3compartmentss NA 50% Rat Human -DTXSID9023914 Css NA 1.369 mg/L 3compartmentss NA 95% Rat Human -DTXSID9023914 Css NA 0.1964 mg/L PBTK NA 50% Rat Human -DTXSID9023914 Css NA 0.8404 mg/L PBTK NA 95% Rat Human +DTXSID9023914 Css NA 0.05125 mg/L 3compartmentss NA 50% Rat Human +DTXSID9023914 Css NA 0.3014 mg/L 3compartmentss NA 95% Rat Human +DTXSID9023914 Css NA 0.04561 mg/L PBTK NA 50% Rat Human +DTXSID9023914 Css NA 0.1922 mg/L PBTK NA 95% Rat Human DTXSID9024063 Clint 20.52 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9024063 Fup 0.2086 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9024063 Vd NA 1.809 L/kg 1compartment NA NA Human Human DTXSID9024063 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9024063 TK.Half.Life NA 3.054 hours 1compartment NA NA Human Human -DTXSID9024063 Css NA 0.1121 mg/L 3compartmentss NA 50% Human Human -DTXSID9024063 Css NA 0.7956 mg/L 3compartmentss NA 95% Human Human -DTXSID9024063 Css NA 0.0948 mg/L PBTK NA 50% Human Human -DTXSID9024063 Css NA 0.6028 mg/L PBTK NA 95% Human Human +DTXSID9024063 Css NA 0.1088 mg/L 3compartmentss NA 50% Human Human +DTXSID9024063 Css NA 0.7759 mg/L 3compartmentss NA 95% Human Human +DTXSID9024063 Css NA 0.0915 mg/L PBTK NA 50% Human Human +DTXSID9024063 Css NA 0.5801 mg/L PBTK NA 95% Human Human DTXSID9024063 Clint 20.52 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9024063 Fup 0.2086 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9024063 Vd NA 1.517 L/kg 1compartment NA NA Rat Human DTXSID9024063 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9024063 TK.Half.Life NA 1.279 hours 1compartment NA NA Rat Human -DTXSID9024063 Css NA 0.0602 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024063 Css NA 0.3158 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024063 Css NA 0.04957 mg/L PBTK NA 50% Rat Human -DTXSID9024063 Css NA 0.2301 mg/L PBTK NA 95% Rat Human +DTXSID9024063 Css NA 0.01338 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024063 Css NA 0.07095 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024063 Css NA 0.01148 mg/L PBTK NA 50% Rat Human +DTXSID9024063 Css NA 0.05434 mg/L PBTK NA 95% Rat Human DTXSID9024065 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9024065 Fup 0.391 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9024065 Vd NA 1.066 L/kg 1compartment NA NA Human Human DTXSID9024065 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID9024065 TK.Half.Life NA 19.2 hours 1compartment NA NA Human Human -DTXSID9024065 Css NA 1.89 mg/L 3compartmentss NA 50% Human Human -DTXSID9024065 Css NA 7.164 mg/L 3compartmentss NA 95% Human Human -DTXSID9024065 Css NA 1.473 mg/L PBTK NA 50% Human Human -DTXSID9024065 Css NA 4.816 mg/L PBTK NA 95% Human Human +DTXSID9024065 Css NA 1.838 mg/L 3compartmentss NA 50% Human Human +DTXSID9024065 Css NA 7.005 mg/L 3compartmentss NA 95% Human Human +DTXSID9024065 Css NA 1.434 mg/L PBTK NA 50% Human Human +DTXSID9024065 Css NA 4.669 mg/L PBTK NA 95% Human Human DTXSID9024065 Clint 5.8 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9024065 Fup 0.35 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9024065 Vd NA 0.8748 L/kg 1compartment NA NA Rat Rat DTXSID9024065 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9024065 TK.Half.Life NA 1.151 hours 1compartment NA NA Rat Rat -DTXSID9024065 Css NA 0.1046 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9024065 Css NA 0.4905 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9024065 Css NA 0.07664 mg/L PBTK NA 50% Rat Rat -DTXSID9024065 Css NA 0.3129 mg/L PBTK NA 95% Rat Rat -DTXSID9024194 Clint NA 1.715 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024194 Fup NA 0.0356 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024194 Vd NA 0.2612 L/kg 1compartment NA NA Human Human -DTXSID9024194 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9024194 TK.Half.Life NA 12.46 hours 1compartment NA NA Human Human -DTXSID9024194 Css NA 8.62 mg/L 3compartmentss NA 50% Human Human -DTXSID9024194 Css NA 46.73 mg/L 3compartmentss NA 95% Human Human -DTXSID9024194 Css NA 5.208 mg/L PBTK NA 50% Human Human -DTXSID9024194 Css NA 27.46 mg/L PBTK NA 95% Human Human -DTXSID9024194 Clint NA 1.715 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024194 Fup NA 0.0356 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024194 Vd NA 0.2522 L/kg 1compartment NA NA Rat Human +DTXSID9024065 Css NA 0.02335 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9024065 Css NA 0.1089 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9024065 Css NA 0.01781 mg/L PBTK NA 50% Rat Rat +DTXSID9024065 Css NA 0.07134 mg/L PBTK NA 95% Rat Rat +DTXSID90241748 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90241748 Fup 0.0045 NA NA https://doi.org/10.1002/bdd.711 NA Human Human +DTXSID90241748 Vd NA 0.8424 L/kg 1compartment NA NA Human Human +DTXSID90241748 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID90241748 TK.Half.Life NA 15.01 hours 1compartment NA NA Human Human +DTXSID90241748 Css NA 2.794 mg/L 3compartmentss NA 50% Human Human +DTXSID90241748 Css NA 26.53 mg/L 3compartmentss NA 95% Human Human +DTXSID90241748 Css NA 1.872 mg/L PBTK NA 50% Human Human +DTXSID90241748 Css NA 17.77 mg/L PBTK NA 95% Human Human +DTXSID90241748 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90241748 Fup 0.0045 NA NA https://doi.org/10.1002/bdd.711 NA Rat Human +DTXSID90241748 Vd NA 1.457 L/kg 1compartment NA NA Rat Human +DTXSID90241748 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90241748 TK.Half.Life NA 4.495 hours 1compartment NA NA Rat Human +DTXSID90241748 Css NA 0.09927 mg/L 3compartmentss NA 50% Rat Human +DTXSID90241748 Css NA 0.7541 mg/L 3compartmentss NA 95% Rat Human +DTXSID90241748 Css NA 0.06882 mg/L PBTK NA 50% Rat Human +DTXSID90241748 Css NA 0.5233 mg/L PBTK NA 95% Rat Human +DTXSID9024194 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024194 Fup 0.052 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024194 Vd NA 0.2988 L/kg 1compartment NA NA Human Human +DTXSID9024194 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9024194 TK.Half.Life NA 1.261 hours 1compartment NA NA Human Human +DTXSID9024194 Css NA 0.5854 mg/L 3compartmentss NA 50% Human Human +DTXSID9024194 Css NA 5.254 mg/L 3compartmentss NA 95% Human Human +DTXSID9024194 Css NA 0.3595 mg/L PBTK NA 50% Human Human +DTXSID9024194 Css NA 3.135 mg/L PBTK NA 95% Human Human +DTXSID9024194 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024194 Fup 0.052 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024194 Vd NA 0.2886 L/kg 1compartment NA NA Rat Human DTXSID9024194 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024194 TK.Half.Life NA 6.583 hours 1compartment NA NA Rat Human -DTXSID9024194 Css NA 3.959 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024194 Css NA 16.42 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024194 Css NA 2.23 mg/L PBTK NA 50% Rat Human -DTXSID9024194 Css NA 8.985 mg/L PBTK NA 95% Rat Human -DTXSID9024300 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024300 Fup NA 0.4935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024300 Vd NA 0.534 L/kg 1compartment NA NA Human Human -DTXSID9024300 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024300 TK.Half.Life NA 7.001 hours 1compartment NA NA Human Human -DTXSID9024300 Css NA 1.474 mg/L 3compartmentss NA 50% Human Human -DTXSID9024300 Css NA 7.614 mg/L 3compartmentss NA 95% Human Human -DTXSID9024300 Css NA 1.114 mg/L PBTK NA 50% Human Human -DTXSID9024300 Css NA 4.762 mg/L PBTK NA 95% Human Human -DTXSID9024300 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024300 Fup NA 0.4935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024300 Vd NA 0.5562 L/kg 1compartment NA NA Rat Human -DTXSID9024300 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024300 TK.Half.Life NA 2.485 hours 1compartment NA NA Rat Human -DTXSID9024300 Css NA 0.397 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024300 Css NA 1.821 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024300 Css NA 0.2864 mg/L PBTK NA 50% Rat Human -DTXSID9024300 Css NA 1.071 mg/L PBTK NA 95% Rat Human +DTXSID9024194 TK.Half.Life NA 0.7641 hours 1compartment NA NA Rat Human +DTXSID9024194 Css NA 0.07719 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024194 Css NA 0.5187 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024194 Css NA 0.04604 mg/L PBTK NA 50% Rat Human +DTXSID9024194 Css NA 0.2976 mg/L PBTK NA 95% Rat Human +DTXSID90242053 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90242053 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90242053 Vd NA 2.161 L/kg 1compartment NA NA Human Human +DTXSID90242053 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID90242053 TK.Half.Life NA 17.97 hours 1compartment NA NA Human Human +DTXSID90242053 Css NA 1.048 mg/L 3compartmentss NA 50% Human Human +DTXSID90242053 Css NA 6.301 mg/L 3compartmentss NA 95% Human Human +DTXSID90242053 Css NA 0.723 mg/L PBTK NA 50% Human Human +DTXSID90242053 Css NA 4.095 mg/L PBTK NA 95% Human Human +DTXSID90242053 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90242053 Fup 0.121 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90242053 Vd NA 1.646 L/kg 1compartment NA NA Rat Human +DTXSID90242053 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90242053 TK.Half.Life NA 5.419 hours 1compartment NA NA Rat Human +DTXSID90242053 Css NA 0.1281 mg/L 3compartmentss NA 50% Rat Human +DTXSID90242053 Css NA 0.5622 mg/L 3compartmentss NA 95% Rat Human +DTXSID90242053 Css NA 0.08766 mg/L PBTK NA 50% Rat Human +DTXSID90242053 Css NA 0.3559 mg/L PBTK NA 95% Rat Human DTXSID9024304 Clint 11.87 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9024304 Fup 0.05472 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9024304 Vd NA 2.104 L/kg 1compartment NA NA Human Human DTXSID9024304 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID9024304 TK.Half.Life NA 18.83 hours 1compartment NA NA Human Human -DTXSID9024304 Css NA 1.277 mg/L 3compartmentss NA 50% Human Human -DTXSID9024304 Css NA 7.928 mg/L 3compartmentss NA 95% Human Human -DTXSID9024304 Css NA 0.848 mg/L PBTK NA 50% Human Human -DTXSID9024304 Css NA 5.014 mg/L PBTK NA 95% Human Human +DTXSID9024304 Css NA 1.231 mg/L 3compartmentss NA 50% Human Human +DTXSID9024304 Css NA 7.996 mg/L 3compartmentss NA 95% Human Human +DTXSID9024304 Css NA 0.8156 mg/L PBTK NA 50% Human Human +DTXSID9024304 Css NA 5.046 mg/L PBTK NA 95% Human Human DTXSID9024304 Clint 11.87 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9024304 Fup 0.05472 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9024304 Vd NA 1.575 L/kg 1compartment NA NA Rat Human DTXSID9024304 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9024304 TK.Half.Life NA 5.747 hours 1compartment NA NA Rat Human -DTXSID9024304 Css NA 0.6809 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024304 Css NA 3.507 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024304 Css NA 0.4288 mg/L PBTK NA 50% Rat Human -DTXSID9024304 Css NA 2.089 mg/L PBTK NA 95% Rat Human -DTXSID9024431 Clint NA 3.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024431 Fup NA 0.7122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024431 Vd NA 2.09 L/kg 1compartment NA NA Human Human +DTXSID9024304 Css NA 0.154 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024304 Css NA 0.8002 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024304 Css NA 0.1003 mg/L PBTK NA 50% Rat Human +DTXSID9024304 Css NA 0.5025 mg/L PBTK NA 95% Rat Human +DTXSID9024431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024431 Fup 0.506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024431 Vd NA 1.359 L/kg 1compartment NA NA Human Human DTXSID9024431 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024431 TK.Half.Life NA 5.157 hours 1compartment NA NA Human Human -DTXSID9024431 Css NA 0.2149 mg/L 3compartmentss NA 50% Human Human -DTXSID9024431 Css NA 1.458 mg/L 3compartmentss NA 95% Human Human -DTXSID9024431 Css NA 0.1903 mg/L PBTK NA 50% Human Human -DTXSID9024431 Css NA 1.059 mg/L PBTK NA 95% Human Human -DTXSID9024431 Clint NA 3.367 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024431 Fup NA 0.7122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024431 Vd NA 1.717 L/kg 1compartment NA NA Rat Human +DTXSID9024431 TK.Half.Life NA 1.354 hours 1compartment NA NA Human Human +DTXSID9024431 Css NA 0.03993 mg/L 3compartmentss NA 50% Human Human +DTXSID9024431 Css NA 0.3626 mg/L 3compartmentss NA 95% Human Human +DTXSID9024431 Css NA 0.03287 mg/L PBTK NA 50% Human Human +DTXSID9024431 Css NA 0.2556 mg/L PBTK NA 95% Human Human +DTXSID9024431 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024431 Fup 0.506 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024431 Vd NA 1.163 L/kg 1compartment NA NA Rat Human DTXSID9024431 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024431 TK.Half.Life NA 1.784 hours 1compartment NA NA Rat Human -DTXSID9024431 Css NA 0.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024431 Css NA 0.5983 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024431 Css NA 0.08662 mg/L PBTK NA 50% Rat Human -DTXSID9024431 Css NA 0.3846 mg/L PBTK NA 95% Rat Human +DTXSID9024431 TK.Half.Life NA 0.5635 hours 1compartment NA NA Rat Human +DTXSID9024431 Css NA 0.004906 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024431 Css NA 0.03568 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024431 Css NA 0.004083 mg/L PBTK NA 50% Rat Human +DTXSID9024431 Css NA 0.02503 mg/L PBTK NA 95% Rat Human DTXSID9024481 Clint 12.02 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID9024481 Fup NA 0.1881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024481 Vd NA 0.727 L/kg 1compartment NA NA Human Human +DTXSID9024481 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024481 Vd NA 0.7367 L/kg 1compartment NA NA Human Human DTXSID9024481 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024481 TK.Half.Life NA 1.746 hours 1compartment NA NA Human Human -DTXSID9024481 Css NA 0.2118 mg/L 3compartmentss NA 50% Human Human -DTXSID9024481 Css NA 1.37 mg/L 3compartmentss NA 95% Human Human -DTXSID9024481 Css NA 0.1448 mg/L PBTK NA 50% Human Human -DTXSID9024481 Css NA 0.894 mg/L PBTK NA 95% Human Human +DTXSID9024481 TK.Half.Life NA 1.386 hours 1compartment NA NA Human Human +DTXSID9024481 Css NA 0.14 mg/L 3compartmentss NA 50% Human Human +DTXSID9024481 Css NA 0.9438 mg/L 3compartmentss NA 95% Human Human +DTXSID9024481 Css NA 0.09921 mg/L PBTK NA 50% Human Human +DTXSID9024481 Css NA 0.6376 mg/L PBTK NA 95% Human Human DTXSID9024481 Clint 12.02 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID9024481 Fup NA 0.1881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024481 Vd NA 0.63 L/kg 1compartment NA NA Rat Human +DTXSID9024481 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024481 Vd NA 0.6618 L/kg 1compartment NA NA Rat Human DTXSID9024481 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024481 TK.Half.Life NA 0.8618 hours 1compartment NA NA Rat Human -DTXSID9024481 Css NA 0.1142 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024481 Css NA 0.5321 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024481 Css NA 0.07426 mg/L PBTK NA 50% Rat Human -DTXSID9024481 Css NA 0.3263 mg/L PBTK NA 95% Rat Human -DTXSID9024483 Clint NA 34.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024483 Fup NA 0.0923 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024483 Vd NA 1.2 L/kg 1compartment NA NA Human Human +DTXSID9024481 TK.Half.Life NA 0.6925 hours 1compartment NA NA Rat Human +DTXSID9024481 Css NA 0.01704 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024481 Css NA 0.08726 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024481 Css NA 0.01202 mg/L PBTK NA 50% Rat Human +DTXSID9024481 Css NA 0.05596 mg/L PBTK NA 95% Rat Human +DTXSID9024483 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024483 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024483 Vd NA 1.184 L/kg 1compartment NA NA Human Human DTXSID9024483 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024483 TK.Half.Life NA 2.536 hours 1compartment NA NA Human Human -DTXSID9024483 Css NA 0.2072 mg/L 3compartmentss NA 50% Human Human -DTXSID9024483 Css NA 1.67 mg/L 3compartmentss NA 95% Human Human -DTXSID9024483 Css NA 0.1347 mg/L PBTK NA 50% Human Human -DTXSID9024483 Css NA 1.049 mg/L PBTK NA 95% Human Human -DTXSID9024483 Clint NA 34.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024483 Fup NA 0.0923 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024483 Vd NA 0.9271 L/kg 1compartment NA NA Rat Human +DTXSID9024483 TK.Half.Life NA 5.762 hours 1compartment NA NA Human Human +DTXSID9024483 Css NA 0.5868 mg/L 3compartmentss NA 50% Human Human +DTXSID9024483 Css NA 3.685 mg/L 3compartmentss NA 95% Human Human +DTXSID9024483 Css NA 0.3983 mg/L PBTK NA 50% Human Human +DTXSID9024483 Css NA 2.372 mg/L PBTK NA 95% Human Human +DTXSID9024483 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024483 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024483 Vd NA 0.9391 L/kg 1compartment NA NA Rat Human DTXSID9024483 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024483 TK.Half.Life NA 1.034 hours 1compartment NA NA Rat Human -DTXSID9024483 Css NA 0.1163 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024483 Css NA 0.7518 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024483 Css NA 0.07136 mg/L PBTK NA 50% Rat Human -DTXSID9024483 Css NA 0.4346 mg/L PBTK NA 95% Rat Human -DTXSID9024485 Clint NA 39.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024485 Fup NA 0.2694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024485 Vd NA 1.523 L/kg 1compartment NA NA Human Human +DTXSID9024483 TK.Half.Life NA 2.464 hours 1compartment NA NA Rat Human +DTXSID9024483 Css NA 0.07086 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024483 Css NA 0.3525 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024483 Css NA 0.04732 mg/L PBTK NA 50% Rat Human +DTXSID9024483 Css NA 0.2172 mg/L PBTK NA 95% Rat Human +DTXSID9024485 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024485 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024485 Vd NA 0.9187 L/kg 1compartment NA NA Human Human DTXSID9024485 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024485 TK.Half.Life NA 1.745 hours 1compartment NA NA Human Human -DTXSID9024485 Css NA 0.05074 mg/L 3compartmentss NA 50% Human Human -DTXSID9024485 Css NA 0.3676 mg/L 3compartmentss NA 95% Human Human -DTXSID9024485 Css NA 0.03785 mg/L PBTK NA 50% Human Human -DTXSID9024485 Css NA 0.2475 mg/L PBTK NA 95% Human Human -DTXSID9024485 Clint NA 39.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024485 Fup NA 0.2694 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024485 Vd NA 1.221 L/kg 1compartment NA NA Rat Human +DTXSID9024485 TK.Half.Life NA 1.394 hours 1compartment NA NA Human Human +DTXSID9024485 Css NA 0.0921 mg/L 3compartmentss NA 50% Human Human +DTXSID9024485 Css NA 0.648 mg/L 3compartmentss NA 95% Human Human +DTXSID9024485 Css NA 0.06556 mg/L PBTK NA 50% Human Human +DTXSID9024485 Css NA 0.4336 mg/L PBTK NA 95% Human Human +DTXSID9024485 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024485 Fup 0.232 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024485 Vd NA 0.7798 L/kg 1compartment NA NA Rat Human DTXSID9024485 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024485 TK.Half.Life NA 0.6646 hours 1compartment NA NA Rat Human -DTXSID9024485 Css NA 0.02798 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024485 Css NA 0.1552 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024485 Css NA 0.02001 mg/L PBTK NA 50% Rat Human -DTXSID9024485 Css NA 0.1037 mg/L PBTK NA 95% Rat Human -DTXSID9024487 Clint NA 4.008 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024487 Fup NA 0.2357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024487 Vd NA 1.343 L/kg 1compartment NA NA Human Human +DTXSID9024485 TK.Half.Life NA 0.629 hours 1compartment NA NA Rat Human +DTXSID9024485 Css NA 0.01145 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024485 Css NA 0.0646 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024485 Css NA 0.008084 mg/L PBTK NA 50% Rat Human +DTXSID9024485 Css NA 0.04176 mg/L PBTK NA 95% Rat Human +DTXSID9024487 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024487 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024487 Vd NA 1.052 L/kg 1compartment NA NA Human Human DTXSID9024487 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024487 TK.Half.Life NA 6.118 hours 1compartment NA NA Human Human -DTXSID9024487 Css NA 0.4686 mg/L 3compartmentss NA 50% Human Human -DTXSID9024487 Css NA 2.467 mg/L 3compartmentss NA 95% Human Human -DTXSID9024487 Css NA 0.3477 mg/L PBTK NA 50% Human Human -DTXSID9024487 Css NA 1.656 mg/L PBTK NA 95% Human Human -DTXSID9024487 Clint NA 4.008 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024487 Fup NA 0.2357 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024487 Vd NA 1.124 L/kg 1compartment NA NA Rat Human +DTXSID9024487 TK.Half.Life NA 2.088 hours 1compartment NA NA Human Human +DTXSID9024487 Css NA 0.17 mg/L 3compartmentss NA 50% Human Human +DTXSID9024487 Css NA 1.319 mg/L 3compartmentss NA 95% Human Human +DTXSID9024487 Css NA 0.1146 mg/L PBTK NA 50% Human Human +DTXSID9024487 Css NA 0.8387 mg/L PBTK NA 95% Human Human +DTXSID9024487 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024487 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024487 Vd NA 0.8759 L/kg 1compartment NA NA Rat Human DTXSID9024487 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024487 TK.Half.Life NA 2.676 hours 1compartment NA NA Rat Human -DTXSID9024487 Css NA 0.2327 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024487 Css NA 0.9101 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024487 Css NA 0.1645 mg/L PBTK NA 50% Rat Human -DTXSID9024487 Css NA 0.5735 mg/L PBTK NA 95% Rat Human +DTXSID9024487 TK.Half.Life NA 0.9494 hours 1compartment NA NA Rat Human +DTXSID9024487 Css NA 0.02158 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024487 Css NA 0.138 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024487 Css NA 0.01451 mg/L PBTK NA 50% Rat Human +DTXSID9024487 Css NA 0.08603 mg/L PBTK NA 95% Rat Human DTXSID9024489 Clint 16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9024489 Fup 0.604 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9024489 Vd NA 0.9088 L/kg 1compartment NA NA Human Human +DTXSID9024489 Vd NA 1.08 L/kg 1compartment NA NA Human Human DTXSID9024489 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024489 TK.Half.Life NA 0.8893 hours 1compartment NA NA Human Human -DTXSID9024489 Css NA 0.0381 mg/L 3compartmentss NA 50% Human Human -DTXSID9024489 Css NA 0.2331 mg/L 3compartmentss NA 95% Human Human -DTXSID9024489 Css NA 0.03194 mg/L PBTK NA 50% Human Human -DTXSID9024489 Css NA 0.186 mg/L PBTK NA 95% Human Human +DTXSID9024489 TK.Half.Life NA 1.054 hours 1compartment NA NA Human Human +DTXSID9024489 Css NA 0.03524 mg/L 3compartmentss NA 50% Human Human +DTXSID9024489 Css NA 0.2349 mg/L 3compartmentss NA 95% Human Human +DTXSID9024489 Css NA 0.03038 mg/L PBTK NA 50% Human Human +DTXSID9024489 Css NA 0.188 mg/L PBTK NA 95% Human Human DTXSID9024489 Clint 16 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9024489 Fup 0.604 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9024489 Vd NA 0.8695 L/kg 1compartment NA NA Rat Human +DTXSID9024489 Vd NA 0.995 L/kg 1compartment NA NA Rat Human DTXSID9024489 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024489 TK.Half.Life NA 0.4313 hours 1compartment NA NA Rat Human -DTXSID9024489 Css NA 0.01971 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024489 Css NA 0.09169 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024489 Css NA 0.01646 mg/L PBTK NA 50% Rat Human -DTXSID9024489 Css NA 0.07003 mg/L PBTK NA 95% Rat Human -DTXSID9024512 Clint NA 14.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024512 Fup NA 0.2431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024512 Vd NA 1.548 L/kg 1compartment NA NA Human Human +DTXSID9024489 TK.Half.Life NA 0.4892 hours 1compartment NA NA Rat Human +DTXSID9024489 Css NA 0.004312 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024489 Css NA 0.02095 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024489 Css NA 0.003815 mg/L PBTK NA 50% Rat Human +DTXSID9024489 Css NA 0.01721 mg/L PBTK NA 95% Rat Human +DTXSID9024512 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024512 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024512 Vd NA 1.509 L/kg 1compartment NA NA Human Human DTXSID9024512 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024512 TK.Half.Life NA 3.1 hours 1compartment NA NA Human Human -DTXSID9024512 Css NA 0.1572 mg/L 3compartmentss NA 50% Human Human -DTXSID9024512 Css NA 1.017 mg/L 3compartmentss NA 95% Human Human -DTXSID9024512 Css NA 0.1154 mg/L PBTK NA 50% Human Human -DTXSID9024512 Css NA 0.7038 mg/L PBTK NA 95% Human Human -DTXSID9024512 Clint NA 14.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024512 Fup NA 0.2431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024512 Vd NA 1.231 L/kg 1compartment NA NA Rat Human +DTXSID9024512 TK.Half.Life NA 2.461 hours 1compartment NA NA Human Human +DTXSID9024512 Css NA 0.1066 mg/L 3compartmentss NA 50% Human Human +DTXSID9024512 Css NA 0.7349 mg/L 3compartmentss NA 95% Human Human +DTXSID9024512 Css NA 0.0776 mg/L PBTK NA 50% Human Human +DTXSID9024512 Css NA 0.4965 mg/L PBTK NA 95% Human Human +DTXSID9024512 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024512 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024512 Vd NA 1.198 L/kg 1compartment NA NA Rat Human DTXSID9024512 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024512 TK.Half.Life NA 1.222 hours 1compartment NA NA Rat Human -DTXSID9024512 Css NA 0.08414 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024512 Css NA 0.4207 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024512 Css NA 0.05952 mg/L PBTK NA 50% Rat Human -DTXSID9024512 Css NA 0.2704 mg/L PBTK NA 95% Rat Human -DTXSID9024568 Clint NA 0.4173 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024568 Fup NA 0.3208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024568 Vd NA 0.5597 L/kg 1compartment NA NA Human Human +DTXSID9024512 TK.Half.Life NA 0.9651 hours 1compartment NA NA Rat Human +DTXSID9024512 Css NA 0.01331 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024512 Css NA 0.06954 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024512 Css NA 0.00967 mg/L PBTK NA 50% Rat Human +DTXSID9024512 Css NA 0.04765 mg/L PBTK NA 95% Rat Human +DTXSID9024568 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024568 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024568 Vd NA 0.4554 L/kg 1compartment NA NA Human Human DTXSID9024568 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024568 TK.Half.Life NA 6.71 hours 1compartment NA NA Human Human -DTXSID9024568 Css NA 1.301 mg/L 3compartmentss NA 50% Human Human -DTXSID9024568 Css NA 5.767 mg/L 3compartmentss NA 95% Human Human -DTXSID9024568 Css NA 0.9592 mg/L PBTK NA 50% Human Human -DTXSID9024568 Css NA 3.648 mg/L PBTK NA 95% Human Human -DTXSID9024568 Clint NA 0.4173 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024568 Fup NA 0.3208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024568 Vd NA 0.5651 L/kg 1compartment NA NA Rat Human +DTXSID9024568 TK.Half.Life NA 0.8515 hours 1compartment NA NA Human Human +DTXSID9024568 Css NA 0.1435 mg/L 3compartmentss NA 50% Human Human +DTXSID9024568 Css NA 0.9885 mg/L 3compartmentss NA 95% Human Human +DTXSID9024568 Css NA 0.1021 mg/L PBTK NA 50% Human Human +DTXSID9024568 Css NA 0.6419 mg/L PBTK NA 95% Human Human +DTXSID9024568 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024568 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024568 Vd NA 0.4755 L/kg 1compartment NA NA Rat Human DTXSID9024568 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024568 TK.Half.Life NA 2.91 hours 1compartment NA NA Rat Human -DTXSID9024568 Css NA 0.4567 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024568 Css NA 1.641 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024568 Css NA 0.3226 mg/L PBTK NA 50% Rat Human -DTXSID9024568 Css NA 0.9767 mg/L PBTK NA 95% Rat Human -DTXSID9024641 Clint NA 1.497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024641 Fup NA 0.2615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024641 Vd NA 2.306 L/kg 1compartment NA NA Human Human -DTXSID9024641 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9024641 TK.Half.Life NA 32.76 hours 1compartment NA NA Human Human -DTXSID9024641 Css NA 1.566 mg/L 3compartmentss NA 50% Human Human -DTXSID9024641 Css NA 6.33 mg/L 3compartmentss NA 95% Human Human -DTXSID9024641 Css NA 1.173 mg/L PBTK NA 50% Human Human -DTXSID9024641 Css NA 4.329 mg/L PBTK NA 95% Human Human -DTXSID9024641 Clint NA 1.497 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024641 Fup NA 0.2615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024641 Vd NA 1.778 L/kg 1compartment NA NA Rat Human -DTXSID9024641 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9024641 TK.Half.Life NA 8.098 hours 1compartment NA NA Rat Human -DTXSID9024641 Css NA 0.6999 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024641 Css NA 2.017 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024641 Css NA 0.5034 mg/L PBTK NA 50% Rat Human -DTXSID9024641 Css NA 1.283 mg/L PBTK NA 95% Rat Human -DTXSID9024699 Clint NA 341.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024699 Fup NA 0.1507 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024699 Vd NA 2.477 L/kg 1compartment NA NA Human Human +DTXSID9024568 TK.Half.Life NA 0.4933 hours 1compartment NA NA Rat Human +DTXSID9024568 Css NA 0.01691 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024568 Css NA 0.08627 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024568 Css NA 0.01193 mg/L PBTK NA 50% Rat Human +DTXSID9024568 Css NA 0.05433 mg/L PBTK NA 95% Rat Human +DTXSID9024641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024641 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024641 Vd NA 1.622 L/kg 1compartment NA NA Human Human +DTXSID9024641 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9024641 TK.Half.Life NA 3.639 hours 1compartment NA NA Human Human +DTXSID9024641 Css NA 0.2004 mg/L 3compartmentss NA 50% Human Human +DTXSID9024641 Css NA 1.495 mg/L 3compartmentss NA 95% Human Human +DTXSID9024641 Css NA 0.1384 mg/L PBTK NA 50% Human Human +DTXSID9024641 Css NA 0.9661 mg/L PBTK NA 95% Human Human +DTXSID9024641 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024641 Fup 0.147 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024641 Vd NA 1.253 L/kg 1compartment NA NA Rat Human +DTXSID9024641 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9024641 TK.Half.Life NA 1.373 hours 1compartment NA NA Rat Human +DTXSID9024641 Css NA 0.0261 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024641 Css NA 0.15 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024641 Css NA 0.01771 mg/L PBTK NA 50% Rat Human +DTXSID9024641 Css NA 0.09634 mg/L PBTK NA 95% Rat Human +DTXSID9024691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024691 Fup 0.629 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024691 Vd NA 0.8748 L/kg 1compartment NA NA Human Human +DTXSID9024691 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9024691 TK.Half.Life NA 0.7627 hours 1compartment NA NA Human Human +DTXSID9024691 Css NA 0.03135 mg/L 3compartmentss NA 50% Human Human +DTXSID9024691 Css NA 0.3418 mg/L 3compartmentss NA 95% Human Human +DTXSID9024691 Css NA 0.0255 mg/L PBTK NA 50% Human Human +DTXSID9024691 Css NA 0.2371 mg/L PBTK NA 95% Human Human +DTXSID9024691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024691 Fup 0.629 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024691 Vd NA 0.8479 L/kg 1compartment NA NA Rat Human +DTXSID9024691 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9024691 TK.Half.Life NA 0.365 hours 1compartment NA NA Rat Human +DTXSID9024691 Css NA 0.003797 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024691 Css NA 0.03557 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024691 Css NA 0.003172 mg/L PBTK NA 50% Rat Human +DTXSID9024691 Css NA 0.02381 mg/L PBTK NA 95% Rat Human +DTXSID9024699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024699 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024699 Vd NA 2.257 L/kg 1compartment NA NA Human Human DTXSID9024699 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024699 TK.Half.Life NA 2.353 hours 1compartment NA NA Human Human -DTXSID9024699 Css NA 0.02143 mg/L 3compartmentss NA 50% Human Human -DTXSID9024699 Css NA 0.1463 mg/L 3compartmentss NA 95% Human Human -DTXSID9024699 Css NA 0.01509 mg/L PBTK NA 50% Human Human -DTXSID9024699 Css NA 0.1002 mg/L PBTK NA 95% Human Human -DTXSID9024699 Clint NA 341.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024699 Fup NA 0.1507 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024699 Vd NA 1.878 L/kg 1compartment NA NA Rat Human +DTXSID9024699 TK.Half.Life NA 5.825 hours 1compartment NA NA Human Human +DTXSID9024699 Css NA 0.2152 mg/L 3compartmentss NA 50% Human Human +DTXSID9024699 Css NA 1.416 mg/L 3compartmentss NA 95% Human Human +DTXSID9024699 Css NA 0.1538 mg/L PBTK NA 50% Human Human +DTXSID9024699 Css NA 0.9633 mg/L PBTK NA 95% Human Human +DTXSID9024699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024699 Fup 0.169 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024699 Vd NA 1.722 L/kg 1compartment NA NA Rat Human DTXSID9024699 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024699 TK.Half.Life NA 0.7477 hours 1compartment NA NA Rat Human -DTXSID9024699 Css NA 0.01208 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024699 Css NA 0.0708 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024699 Css NA 0.008141 mg/L PBTK NA 50% Rat Human -DTXSID9024699 Css NA 0.04541 mg/L PBTK NA 95% Rat Human +DTXSID9024699 TK.Half.Life NA 1.79 hours 1compartment NA NA Rat Human +DTXSID9024699 Css NA 0.0275 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024699 Css NA 0.1358 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024699 Css NA 0.01953 mg/L PBTK NA 50% Rat Human +DTXSID9024699 Css NA 0.09343 mg/L PBTK NA 95% Rat Human +DTXSID9024724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024724 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024724 Vd NA 1.952 L/kg 1compartment NA NA Human Human +DTXSID9024724 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9024724 TK.Half.Life NA 4.311 hours 1compartment NA NA Human Human +DTXSID9024724 Css NA 0.1736 mg/L 3compartmentss NA 50% Human Human +DTXSID9024724 Css NA 1.151 mg/L 3compartmentss NA 95% Human Human +DTXSID9024724 Css NA 0.1237 mg/L PBTK NA 50% Human Human +DTXSID9024724 Css NA 0.7762 mg/L PBTK NA 95% Human Human +DTXSID9024724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024724 Fup 0.174 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024724 Vd NA 1.501 L/kg 1compartment NA NA Rat Human +DTXSID9024724 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9024724 TK.Half.Life NA 1.484 hours 1compartment NA NA Rat Human +DTXSID9024724 Css NA 0.02181 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024724 Css NA 0.1111 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024724 Css NA 0.01555 mg/L PBTK NA 50% Rat Human +DTXSID9024724 Css NA 0.07434 mg/L PBTK NA 95% Rat Human DTXSID9024726 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9024726 Fup NA 0.8439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024726 Vd NA 0.6546 L/kg 1compartment NA NA Human Human +DTXSID9024726 Vd NA 0.6762 L/kg 1compartment NA NA Human Human DTXSID9024726 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024726 TK.Half.Life NA 5.019 hours 1compartment NA NA Human Human -DTXSID9024726 Css NA 0.9834 mg/L 3compartmentss NA 50% Human Human -DTXSID9024726 Css NA 5.652 mg/L 3compartmentss NA 95% Human Human -DTXSID9024726 Css NA 0.7907 mg/L PBTK NA 50% Human Human -DTXSID9024726 Css NA 3.624 mg/L PBTK NA 95% Human Human +DTXSID9024726 TK.Half.Life NA 5.184 hours 1compartment NA NA Human Human +DTXSID9024726 Css NA 0.8281 mg/L 3compartmentss NA 50% Human Human +DTXSID9024726 Css NA 4.937 mg/L 3compartmentss NA 95% Human Human +DTXSID9024726 Css NA 0.6742 mg/L PBTK NA 50% Human Human +DTXSID9024726 Css NA 3.123 mg/L PBTK NA 95% Human Human DTXSID9024726 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9024726 Fup NA 0.8439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024726 Vd NA 0.6957 L/kg 1compartment NA NA Rat Human +DTXSID9024726 Vd NA 0.7138 L/kg 1compartment NA NA Rat Human DTXSID9024726 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024726 TK.Half.Life NA 1.818 hours 1compartment NA NA Rat Human -DTXSID9024726 Css NA 0.251 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024726 Css NA 1.443 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024726 Css NA 0.1958 mg/L PBTK NA 50% Rat Human -DTXSID9024726 Css NA 0.8585 mg/L PBTK NA 95% Rat Human -DTXSID9024770 Clint NA 0.2205 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024770 Fup NA 0.0674 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024770 Vd NA 0.3291 L/kg 1compartment NA NA Human Human -DTXSID9024770 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9024770 TK.Half.Life NA 23.17 hours 1compartment NA NA Human Human -DTXSID9024770 Css NA 10.84 mg/L 3compartmentss NA 50% Human Human -DTXSID9024770 Css NA 48.93 mg/L 3compartmentss NA 95% Human Human -DTXSID9024770 Css NA 6.802 mg/L PBTK NA 50% Human Human -DTXSID9024770 Css NA 28.99 mg/L PBTK NA 95% Human Human -DTXSID9024770 Clint NA 0.2205 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024770 Fup NA 0.0674 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024770 Vd NA 0.3219 L/kg 1compartment NA NA Rat Human +DTXSID9024726 TK.Half.Life NA 1.865 hours 1compartment NA NA Rat Human +DTXSID9024726 Css NA 0.01551 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024726 Css NA 0.1134 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024726 Css NA 0.01212 mg/L PBTK NA 50% Rat Human +DTXSID9024726 Css NA 0.07427 mg/L PBTK NA 95% Rat Human +DTXSID9024770 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024770 Fup 0.0732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024770 Vd NA 0.341 L/kg 1compartment NA NA Human Human +DTXSID9024770 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9024770 TK.Half.Life NA 1.105 hours 1compartment NA NA Human Human +DTXSID9024770 Css NA 0.3946 mg/L 3compartmentss NA 50% Human Human +DTXSID9024770 Css NA 3.299 mg/L 3compartmentss NA 95% Human Human +DTXSID9024770 Css NA 0.247 mg/L PBTK NA 50% Human Human +DTXSID9024770 Css NA 1.976 mg/L PBTK NA 95% Human Human +DTXSID9024770 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024770 Fup 0.0732 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024770 Vd NA 0.3337 L/kg 1compartment NA NA Rat Human DTXSID9024770 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024770 TK.Half.Life NA 8.95 hours 1compartment NA NA Rat Human -DTXSID9024770 Css NA 3.673 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024770 Css NA 13.81 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024770 Css NA 2.144 mg/L PBTK NA 50% Rat Human -DTXSID9024770 Css NA 7.635 mg/L PBTK NA 95% Rat Human -DTXSID9024772 Clint NA 0.006691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024772 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024772 Vd NA 0.2887 L/kg 1compartment NA NA Human Human -DTXSID9024772 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID9024772 TK.Half.Life NA 32.03 hours 1compartment NA NA Human Human -DTXSID9024772 Css NA 17.98 mg/L 3compartmentss NA 50% Human Human -DTXSID9024772 Css NA 85.06 mg/L 3compartmentss NA 95% Human Human -DTXSID9024772 Css NA 10.98 mg/L PBTK NA 50% Human Human -DTXSID9024772 Css NA 50.19 mg/L PBTK NA 95% Human Human -DTXSID9024772 Clint NA 0.006691 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024772 Fup NA 0.0577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024772 Vd NA 0.2819 L/kg 1compartment NA NA Rat Human -DTXSID9024772 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9024772 TK.Half.Life NA 10.72 hours 1compartment NA NA Rat Human -DTXSID9024772 Css NA 5.201 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024772 Css NA 21.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024772 Css NA 2.982 mg/L PBTK NA 50% Rat Human -DTXSID9024772 Css NA 11.55 mg/L PBTK NA 95% Rat Human -DTXSID9024809 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024809 Fup NA 0.902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024809 Vd NA 1.035 L/kg 1compartment NA NA Human Human +DTXSID9024770 TK.Half.Life NA 0.662 hours 1compartment NA NA Rat Human +DTXSID9024770 Css NA 0.05226 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024770 Css NA 0.3333 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024770 Css NA 0.03176 mg/L PBTK NA 50% Rat Human +DTXSID9024770 Css NA 0.1956 mg/L PBTK NA 95% Rat Human +DTXSID9024772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024772 Fup 0.06 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024772 Vd NA 0.293 L/kg 1compartment NA NA Human Human +DTXSID9024772 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9024772 TK.Half.Life NA 1.11 hours 1compartment NA NA Human Human +DTXSID9024772 Css NA 0.5098 mg/L 3compartmentss NA 50% Human Human +DTXSID9024772 Css NA 4.092 mg/L 3compartmentss NA 95% Human Human +DTXSID9024772 Css NA 0.3131 mg/L PBTK NA 50% Human Human +DTXSID9024772 Css NA 2.441 mg/L PBTK NA 95% Human Human +DTXSID9024772 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024772 Fup 0.06 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024772 Vd NA 0.2861 L/kg 1compartment NA NA Rat Human +DTXSID9024772 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9024772 TK.Half.Life NA 0.673 hours 1compartment NA NA Rat Human +DTXSID9024772 Css NA 0.06612 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024772 Css NA 0.4223 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024772 Css NA 0.0394 mg/L PBTK NA 50% Rat Human +DTXSID9024772 Css NA 0.2447 mg/L PBTK NA 95% Rat Human +DTXSID9024809 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024809 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024809 Vd NA 0.8801 L/kg 1compartment NA NA Human Human DTXSID9024809 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024809 TK.Half.Life NA 7.578 hours 1compartment NA NA Human Human -DTXSID9024809 Css NA 0.8357 mg/L 3compartmentss NA 50% Human Human -DTXSID9024809 Css NA 3.352 mg/L 3compartmentss NA 95% Human Human -DTXSID9024809 Css NA 0.7391 mg/L PBTK NA 50% Human Human -DTXSID9024809 Css NA 2.396 mg/L PBTK NA 95% Human Human -DTXSID9024809 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024809 Fup NA 0.902 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024809 Vd NA 1.017 L/kg 1compartment NA NA Rat Human +DTXSID9024809 TK.Half.Life NA 0.7302 hours 1compartment NA NA Human Human +DTXSID9024809 Css NA 0.02254 mg/L 3compartmentss NA 50% Human Human +DTXSID9024809 Css NA 0.2753 mg/L 3compartmentss NA 95% Human Human +DTXSID9024809 Css NA 0.01869 mg/L PBTK NA 50% Human Human +DTXSID9024809 Css NA 0.1925 mg/L PBTK NA 95% Human Human +DTXSID9024809 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024809 Fup 0.691 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024809 Vd NA 0.8633 L/kg 1compartment NA NA Rat Human DTXSID9024809 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024809 TK.Half.Life NA 2.498 hours 1compartment NA NA Rat Human -DTXSID9024809 Css NA 0.2147 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024809 Css NA 0.8172 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024809 Css NA 0.1869 mg/L PBTK NA 50% Rat Human -DTXSID9024809 Css NA 0.5355 mg/L PBTK NA 95% Rat Human -DTXSID9024853 Clint NA 10.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024853 Fup NA 0.6866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024853 Vd NA 1.266 L/kg 1compartment NA NA Human Human -DTXSID9024853 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024853 TK.Half.Life NA 1.341 hours 1compartment NA NA Human Human -DTXSID9024853 Css NA 0.06094 mg/L 3compartmentss NA 50% Human Human -DTXSID9024853 Css NA 0.5672 mg/L 3compartmentss NA 95% Human Human -DTXSID9024853 Css NA 0.05329 mg/L PBTK NA 50% Human Human -DTXSID9024853 Css NA 0.4074 mg/L PBTK NA 95% Human Human -DTXSID9024853 Clint NA 10.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024853 Fup NA 0.6866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024853 Vd NA 1.146 L/kg 1compartment NA NA Rat Human -DTXSID9024853 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024853 TK.Half.Life NA 0.615 hours 1compartment NA NA Rat Human -DTXSID9024853 Css NA 0.02966 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024853 Css NA 0.2532 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024853 Css NA 0.02561 mg/L PBTK NA 50% Rat Human -DTXSID9024853 Css NA 0.1653 mg/L PBTK NA 95% Rat Human -DTXSID9024855 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024855 Fup NA 0.5295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024855 Vd NA 0.9969 L/kg 1compartment NA NA Human Human +DTXSID9024809 TK.Half.Life NA 0.3511 hours 1compartment NA NA Rat Human +DTXSID9024809 Css NA 0.0007972 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024809 Css NA 0.01169 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024809 Css NA 0.0006566 mg/L PBTK NA 50% Rat Human +DTXSID9024809 Css NA 0.007837 mg/L PBTK NA 95% Rat Human +DTXSID9024855 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024855 Fup 0.429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024855 Vd NA 0.9289 L/kg 1compartment NA NA Human Human DTXSID9024855 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024855 TK.Half.Life NA 1.031 hours 1compartment NA NA Human Human -DTXSID9024855 Css NA 0.0487 mg/L 3compartmentss NA 50% Human Human -DTXSID9024855 Css NA 0.4597 mg/L 3compartmentss NA 95% Human Human -DTXSID9024855 Css NA 0.03976 mg/L PBTK NA 50% Human Human -DTXSID9024855 Css NA 0.3202 mg/L PBTK NA 95% Human Human -DTXSID9024855 Clint NA 16.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024855 Fup NA 0.5295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024855 Vd NA 0.9193 L/kg 1compartment NA NA Rat Human +DTXSID9024855 TK.Half.Life NA 0.9919 hours 1compartment NA NA Human Human +DTXSID9024855 Css NA 0.04471 mg/L 3compartmentss NA 50% Human Human +DTXSID9024855 Css NA 0.3816 mg/L 3compartmentss NA 95% Human Human +DTXSID9024855 Css NA 0.03461 mg/L PBTK NA 50% Human Human +DTXSID9024855 Css NA 0.2679 mg/L PBTK NA 95% Human Human +DTXSID9024855 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024855 Fup 0.429 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024855 Vd NA 0.8455 L/kg 1compartment NA NA Rat Human DTXSID9024855 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024855 TK.Half.Life NA 0.483 hours 1compartment NA NA Rat Human -DTXSID9024855 Css NA 0.02595 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024855 Css NA 0.1871 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024855 Css NA 0.02058 mg/L PBTK NA 50% Rat Human -DTXSID9024855 Css NA 0.1231 mg/L PBTK NA 95% Rat Human +DTXSID9024855 TK.Half.Life NA 0.4581 hours 1compartment NA NA Rat Human +DTXSID9024855 Css NA 0.005451 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024855 Css NA 0.03652 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024855 Css NA 0.004276 mg/L PBTK NA 50% Rat Human +DTXSID9024855 Css NA 0.02562 mg/L PBTK NA 95% Rat Human DTXSID9024930 Clint 8.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9024930 Fup NA 0.7297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024930 Vd NA 0.9773 L/kg 1compartment NA NA Human Human +DTXSID9024930 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024930 Vd NA 0.9104 L/kg 1compartment NA NA Human Human DTXSID9024930 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9024930 TK.Half.Life NA 1.099 hours 1compartment NA NA Human Human -DTXSID9024930 Css NA 0.07522 mg/L 3compartmentss NA 50% Human Human -DTXSID9024930 Css NA 0.6861 mg/L 3compartmentss NA 95% Human Human -DTXSID9024930 Css NA 0.06366 mg/L PBTK NA 50% Human Human -DTXSID9024930 Css NA 0.4814 mg/L PBTK NA 95% Human Human +DTXSID9024930 TK.Half.Life NA 1.113 hours 1compartment NA NA Human Human +DTXSID9024930 Css NA 0.07746 mg/L 3compartmentss NA 50% Human Human +DTXSID9024930 Css NA 0.8282 mg/L 3compartmentss NA 95% Human Human +DTXSID9024930 Css NA 0.06456 mg/L PBTK NA 50% Human Human +DTXSID9024930 Css NA 0.5517 mg/L PBTK NA 95% Human Human DTXSID9024930 Clint 8.27 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9024930 Fup NA 0.7297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024930 Vd NA 0.9465 L/kg 1compartment NA NA Rat Human +DTXSID9024930 Fup 0.649 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024930 Vd NA 0.8811 L/kg 1compartment NA NA Rat Human DTXSID9024930 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024930 TK.Half.Life NA 0.5559 hours 1compartment NA NA Rat Human -DTXSID9024930 Css NA 0.03678 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024930 Css NA 0.2952 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024930 Css NA 0.03076 mg/L PBTK NA 50% Rat Human -DTXSID9024930 Css NA 0.1882 mg/L PBTK NA 95% Rat Human -DTXSID9024934 Clint NA 15.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024934 Fup NA 0.0481 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024934 Vd NA 1.974 L/kg 1compartment NA NA Human Human -DTXSID9024934 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9024934 TK.Half.Life NA 14.85 hours 1compartment NA NA Human Human -DTXSID9024934 Css NA 1.067 mg/L 3compartmentss NA 50% Human Human -DTXSID9024934 Css NA 7.495 mg/L 3compartmentss NA 95% Human Human -DTXSID9024934 Css NA 0.6961 mg/L PBTK NA 50% Human Human -DTXSID9024934 Css NA 4.714 mg/L PBTK NA 95% Human Human -DTXSID9024934 Clint NA 15.08 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024934 Fup NA 0.0481 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024934 Vd NA 1.478 L/kg 1compartment NA NA Rat Human +DTXSID9024930 TK.Half.Life NA 0.5686 hours 1compartment NA NA Rat Human +DTXSID9024930 Css NA 0.008954 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024930 Css NA 0.07771 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024930 Css NA 0.007586 mg/L PBTK NA 50% Rat Human +DTXSID9024930 Css NA 0.04942 mg/L PBTK NA 95% Rat Human +DTXSID9024934 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024934 Fup 0.0447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024934 Vd NA 1.705 L/kg 1compartment NA NA Human Human +DTXSID9024934 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9024934 TK.Half.Life NA 9.126 hours 1compartment NA NA Human Human +DTXSID9024934 Css NA 0.7188 mg/L 3compartmentss NA 50% Human Human +DTXSID9024934 Css NA 5.488 mg/L 3compartmentss NA 95% Human Human +DTXSID9024934 Css NA 0.4621 mg/L PBTK NA 50% Human Human +DTXSID9024934 Css NA 3.406 mg/L PBTK NA 95% Human Human +DTXSID9024934 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024934 Fup 0.0447 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024934 Vd NA 1.277 L/kg 1compartment NA NA Rat Human DTXSID9024934 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9024934 TK.Half.Life NA 4.854 hours 1compartment NA NA Rat Human -DTXSID9024934 Css NA 0.5938 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024934 Css NA 3.224 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024934 Css NA 0.3662 mg/L PBTK NA 50% Rat Human -DTXSID9024934 Css NA 1.904 mg/L PBTK NA 95% Rat Human -DTXSID9024980 Clint NA 0.009632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024980 Fup NA 0.0241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024980 Vd NA 0.2506 L/kg 1compartment NA NA Human Human -DTXSID9024980 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID9024980 TK.Half.Life NA 66.27 hours 1compartment NA NA Human Human -DTXSID9024980 Css NA 44.32 mg/L 3compartmentss NA 50% Human Human -DTXSID9024980 Css NA 273.5 mg/L 3compartmentss NA 95% Human Human -DTXSID9024980 Css NA 26.42 mg/L PBTK NA 50% Human Human -DTXSID9024980 Css NA 157.6 mg/L PBTK NA 95% Human Human -DTXSID9024980 Clint NA 0.009632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024980 Fup NA 0.0241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9024980 Vd NA 0.2426 L/kg 1compartment NA NA Rat Human -DTXSID9024980 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9024980 TK.Half.Life NA 22.03 hours 1compartment NA NA Rat Human -DTXSID9024980 Css NA 12.74 mg/L 3compartmentss NA 50% Rat Human -DTXSID9024980 Css NA 73.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID9024980 Css NA 7.127 mg/L PBTK NA 50% Rat Human -DTXSID9024980 Css NA 39.94 mg/L PBTK NA 95% Rat Human -DTXSID9024986 Clint NA 0.6529 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024986 Fup NA 0.0418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9024986 Vd NA 1.747 L/kg 1compartment NA NA Human Human -DTXSID9024986 Days.Css NA 36 Days PBTK NA NA Human Human -DTXSID9024986 TK.Half.Life NA 174.1 hours 1compartment NA NA Human Human -DTXSID9024986 Css NA 15.48 mg/L 3compartmentss NA 50% Human Human -DTXSID9024986 Css NA 65.64 mg/L 3compartmentss NA 95% Human Human -DTXSID9024986 Css NA 10 mg/L PBTK NA 50% Human Human -DTXSID9024986 Css NA 39.57 mg/L PBTK NA 95% Human Human +DTXSID9024934 TK.Half.Life NA 3.307 hours 1compartment NA NA Rat Human +DTXSID9024934 Css NA 0.09418 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024934 Css NA 0.5552 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024934 Css NA 0.05908 mg/L PBTK NA 50% Rat Human +DTXSID9024934 Css NA 0.3352 mg/L PBTK NA 95% Rat Human +DTXSID9024980 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024980 Fup 0.0407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024980 Vd NA 0.3009 L/kg 1compartment NA NA Human Human +DTXSID9024980 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9024980 TK.Half.Life NA 1.553 hours 1compartment NA NA Human Human +DTXSID9024980 Css NA 0.7797 mg/L 3compartmentss NA 50% Human Human +DTXSID9024980 Css NA 7.455 mg/L 3compartmentss NA 95% Human Human +DTXSID9024980 Css NA 0.4808 mg/L PBTK NA 50% Human Human +DTXSID9024980 Css NA 4.357 mg/L PBTK NA 95% Human Human +DTXSID9024980 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024980 Fup 0.0407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9024980 Vd NA 0.2913 L/kg 1compartment NA NA Rat Human +DTXSID9024980 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9024980 TK.Half.Life NA 0.9578 hours 1compartment NA NA Rat Human +DTXSID9024980 Css NA 0.1033 mg/L 3compartmentss NA 50% Rat Human +DTXSID9024980 Css NA 0.7665 mg/L 3compartmentss NA 95% Rat Human +DTXSID9024980 Css NA 0.06107 mg/L PBTK NA 50% Rat Human +DTXSID9024980 Css NA 0.4385 mg/L PBTK NA 95% Rat Human +DTXSID9024986 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024986 Fup 0.0118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9024986 Vd NA 1.773 L/kg 1compartment NA NA Human Human +DTXSID9024986 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9024986 TK.Half.Life NA 24.33 hours 1compartment NA NA Human Human +DTXSID9024986 Css NA 2.138 mg/L 3compartmentss NA 50% Human Human +DTXSID9024986 Css NA 18.88 mg/L 3compartmentss NA 95% Human Human +DTXSID9024986 Css NA 1.349 mg/L PBTK NA 50% Human Human +DTXSID9024986 Css NA 11.39 mg/L PBTK NA 95% Human Human DTXSID9024986 Clint 49.4 NA uL/min/million hepatocytes NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat DTXSID9024986 Fup 0 NA NA https://doi.org/10.1371/journal.pone.0217564 NA Rat Rat -DTXSID9024986 Css NA 1.145 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9024986 Css NA 9.387 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9025035 Clint NA 11.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025035 Fup NA 0.053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025035 Vd NA 1.305 L/kg 1compartment NA NA Human Human +DTXSID9024986 Css NA 0.238 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9024986 Css NA 1.914 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9025035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025035 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025035 Vd NA 2.119 L/kg 1compartment NA NA Human Human DTXSID9025035 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025035 TK.Half.Life NA 9.4 hours 1compartment NA NA Human Human -DTXSID9025035 Css NA 1.088 mg/L 3compartmentss NA 50% Human Human -DTXSID9025035 Css NA 7.677 mg/L 3compartmentss NA 95% Human Human -DTXSID9025035 Css NA 0.7004 mg/L PBTK NA 50% Human Human -DTXSID9025035 Css NA 4.659 mg/L PBTK NA 95% Human Human -DTXSID9025035 Clint NA 11.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025035 Fup NA 0.053 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025035 Vd NA 1.022 L/kg 1compartment NA NA Rat Human +DTXSID9025035 TK.Half.Life NA 4.507 hours 1compartment NA NA Human Human +DTXSID9025035 Css NA 0.1639 mg/L 3compartmentss NA 50% Human Human +DTXSID9025035 Css NA 1.156 mg/L 3compartmentss NA 95% Human Human +DTXSID9025035 Css NA 0.1212 mg/L PBTK NA 50% Human Human +DTXSID9025035 Css NA 0.8044 mg/L PBTK NA 95% Human Human +DTXSID9025035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025035 Fup 0.177 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025035 Vd NA 1.697 L/kg 1compartment NA NA Rat Human DTXSID9025035 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025035 TK.Half.Life NA 4.073 hours 1compartment NA NA Rat Human -DTXSID9025035 Css NA 0.5902 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025035 Css NA 3.434 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025035 Css NA 0.3565 mg/L PBTK NA 50% Rat Human -DTXSID9025035 Css NA 1.96 mg/L PBTK NA 95% Rat Human -DTXSID9025037 Clint NA 4.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025037 Fup NA 0.2822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025037 Vd NA 2.058 L/kg 1compartment NA NA Human Human +DTXSID9025035 TK.Half.Life NA 1.636 hours 1compartment NA NA Rat Human +DTXSID9025035 Css NA 0.02088 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025035 Css NA 0.1083 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025035 Css NA 0.01534 mg/L PBTK NA 50% Rat Human +DTXSID9025035 Css NA 0.07479 mg/L PBTK NA 95% Rat Human +DTXSID9025037 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025037 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025037 Vd NA 1.775 L/kg 1compartment NA NA Human Human DTXSID9025037 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025037 TK.Half.Life NA 9.335 hours 1compartment NA NA Human Human -DTXSID9025037 Css NA 0.4538 mg/L 3compartmentss NA 50% Human Human -DTXSID9025037 Css NA 2.426 mg/L 3compartmentss NA 95% Human Human -DTXSID9025037 Css NA 0.345 mg/L PBTK NA 50% Human Human -DTXSID9025037 Css NA 1.703 mg/L PBTK NA 95% Human Human -DTXSID9025037 Clint NA 4.721 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025037 Fup NA 0.2822 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025037 Vd NA 1.622 L/kg 1compartment NA NA Rat Human +DTXSID9025037 TK.Half.Life NA 3.081 hours 1compartment NA NA Human Human +DTXSID9025037 Css NA 0.1188 mg/L 3compartmentss NA 50% Human Human +DTXSID9025037 Css NA 0.7948 mg/L 3compartmentss NA 95% Human Human +DTXSID9025037 Css NA 0.0869 mg/L PBTK NA 50% Human Human +DTXSID9025037 Css NA 0.5431 mg/L PBTK NA 95% Human Human +DTXSID9025037 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025037 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025037 Vd NA 1.388 L/kg 1compartment NA NA Rat Human DTXSID9025037 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025037 TK.Half.Life NA 3.107 hours 1compartment NA NA Rat Human -DTXSID9025037 Css NA 0.2273 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025037 Css NA 0.8711 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025037 Css NA 0.1668 mg/L PBTK NA 50% Rat Human -DTXSID9025037 Css NA 0.5675 mg/L PBTK NA 95% Rat Human +DTXSID9025037 TK.Half.Life NA 1.128 hours 1compartment NA NA Rat Human +DTXSID9025037 Css NA 0.01485 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025037 Css NA 0.07634 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025037 Css NA 0.01081 mg/L PBTK NA 50% Rat Human +DTXSID9025037 Css NA 0.05252 mg/L PBTK NA 95% Rat Human DTXSID9025085 Clint NA 0.1678 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9025085 Fup NA 0.7096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9025085 Vd NA 2.2 L/kg 1compartment NA NA Human Human DTXSID9025085 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID9025085 TK.Half.Life NA 15.64 hours 1compartment NA NA Human Human -DTXSID9025085 Css NA 0.6095 mg/L 3compartmentss NA 50% Human Human -DTXSID9025085 Css NA 4.638 mg/L 3compartmentss NA 95% Human Human -DTXSID9025085 Css NA 0.668 mg/L PBTK NA 50% Human Human -DTXSID9025085 Css NA 3.306 mg/L PBTK NA 95% Human Human +DTXSID9025085 Css NA 0.5129 mg/L 3compartmentss NA 50% Human Human +DTXSID9025085 Css NA 3.914 mg/L 3compartmentss NA 95% Human Human +DTXSID9025085 Css NA 0.5681 mg/L PBTK NA 50% Human Human +DTXSID9025085 Css NA 2.819 mg/L PBTK NA 95% Human Human DTXSID9025085 Clint NA 0.1678 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9025085 Fup NA 0.7096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9025085 Vd NA 2.176 L/kg 1compartment NA NA Rat Human DTXSID9025085 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9025085 TK.Half.Life NA 5.94 hours 1compartment NA NA Rat Human -DTXSID9025085 Css NA 0.1755 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025085 Css NA 1.405 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025085 Css NA 0.1907 mg/L PBTK NA 50% Rat Human -DTXSID9025085 Css NA 0.9191 mg/L PBTK NA 95% Rat Human -DTXSID9025087 Clint NA 10.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025087 Fup NA 0.1497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025087 Vd NA 3.037 L/kg 1compartment NA NA Human Human -DTXSID9025087 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025087 TK.Half.Life NA 7.102 hours 1compartment NA NA Human Human -DTXSID9025087 Css NA 0.1918 mg/L 3compartmentss NA 50% Human Human -DTXSID9025087 Css NA 1.632 mg/L 3compartmentss NA 95% Human Human -DTXSID9025087 Css NA 0.1829 mg/L PBTK NA 50% Human Human -DTXSID9025087 Css NA 1.247 mg/L PBTK NA 95% Human Human -DTXSID9025087 Clint NA 10.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025087 Fup NA 0.1497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025087 Vd NA 2.978 L/kg 1compartment NA NA Rat Human -DTXSID9025087 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025087 TK.Half.Life NA 3.965 hours 1compartment NA NA Rat Human -DTXSID9025087 Css NA 0.1021 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025087 Css NA 0.6592 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025087 Css NA 0.09463 mg/L PBTK NA 50% Rat Human -DTXSID9025087 Css NA 0.482 mg/L PBTK NA 95% Rat Human -DTXSID9025110 Clint NA 26.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025110 Fup NA 0.0277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025110 Vd NA 3.106 L/kg 1compartment NA NA Human Human -DTXSID9025110 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID9025110 TK.Half.Life NA 66.39 hours 1compartment NA NA Human Human -DTXSID9025110 Css NA 2.575 mg/L 3compartmentss NA 50% Human Human -DTXSID9025110 Css NA 17.14 mg/L 3compartmentss NA 95% Human Human -DTXSID9025110 Css NA 1.792 mg/L PBTK NA 50% Human Human -DTXSID9025110 Css NA 11.3 mg/L PBTK NA 95% Human Human -DTXSID9025110 Clint NA 26.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025110 Fup NA 0.0277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025110 Vd NA 2.326 L/kg 1compartment NA NA Rat Human -DTXSID9025110 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID9025110 TK.Half.Life NA 9.256 hours 1compartment NA NA Rat Human -DTXSID9025110 Css NA 1.445 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025110 Css NA 7.881 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025110 Css NA 0.9614 mg/L PBTK NA 50% Rat Human -DTXSID9025110 Css NA 4.971 mg/L PBTK NA 95% Rat Human -DTXSID9025114 Clint NA 72.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025114 Fup NA 0.0223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025114 Vd NA 2.238 L/kg 1compartment NA NA Human Human -DTXSID9025114 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025114 TK.Half.Life NA 8.34 hours 1compartment NA NA Human Human -DTXSID9025114 Css NA 0.4612 mg/L 3compartmentss NA 50% Human Human -DTXSID9025114 Css NA 3.641 mg/L 3compartmentss NA 95% Human Human -DTXSID9025114 Css NA 0.3003 mg/L PBTK NA 50% Human Human -DTXSID9025114 Css NA 2.311 mg/L PBTK NA 95% Human Human -DTXSID9025114 Clint NA 72.21 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025114 Fup NA 0.0223 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025114 Vd NA 1.669 L/kg 1compartment NA NA Rat Human -DTXSID9025114 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025114 TK.Half.Life NA 2.476 hours 1compartment NA NA Rat Human -DTXSID9025114 Css NA 0.2576 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025114 Css NA 1.725 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025114 Css NA 0.1593 mg/L PBTK NA 50% Rat Human -DTXSID9025114 Css NA 1.031 mg/L PBTK NA 95% Rat Human -DTXSID9025164 Clint NA 4.349 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025164 Fup NA 0.1314 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025164 Vd NA 1.849 L/kg 1compartment NA NA Human Human +DTXSID9025085 Css NA 0.01096 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025085 Css NA 0.1096 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025085 Css NA 0.01188 mg/L PBTK NA 50% Rat Human +DTXSID9025085 Css NA 0.07933 mg/L PBTK NA 95% Rat Human +DTXSID9025114 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025114 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025114 Vd NA 2.798 L/kg 1compartment NA NA Human Human +DTXSID9025114 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID9025114 TK.Half.Life NA 46.77 hours 1compartment NA NA Human Human +DTXSID9025114 Css NA 2.202 mg/L 3compartmentss NA 50% Human Human +DTXSID9025114 Css NA 15.57 mg/L 3compartmentss NA 95% Human Human +DTXSID9025114 Css NA 1.488 mg/L PBTK NA 50% Human Human +DTXSID9025114 Css NA 9.956 mg/L PBTK NA 95% Human Human +DTXSID9025114 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025114 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025114 Vd NA 2.092 L/kg 1compartment NA NA Rat Human +DTXSID9025114 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID9025114 TK.Half.Life NA 9.154 hours 1compartment NA NA Rat Human +DTXSID9025114 Css NA 0.2856 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025114 Css NA 1.709 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025114 Css NA 0.1894 mg/L PBTK NA 50% Rat Human +DTXSID9025114 Css NA 1.115 mg/L PBTK NA 95% Rat Human +DTXSID9025164 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025164 Fup 0.0846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025164 Vd NA 1.54 L/kg 1compartment NA NA Human Human DTXSID9025164 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9025164 TK.Half.Life NA 16.57 hours 1compartment NA NA Human Human -DTXSID9025164 Css NA 1.191 mg/L 3compartmentss NA 50% Human Human -DTXSID9025164 Css NA 6.867 mg/L 3compartmentss NA 95% Human Human -DTXSID9025164 Css NA 0.8213 mg/L PBTK NA 50% Human Human -DTXSID9025164 Css NA 4.398 mg/L PBTK NA 95% Human Human -DTXSID9025164 Clint NA 4.349 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025164 Fup NA 0.1314 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025164 Vd NA 1.414 L/kg 1compartment NA NA Rat Human +DTXSID9025164 TK.Half.Life NA 13.4 hours 1compartment NA NA Human Human +DTXSID9025164 Css NA 1.215 mg/L 3compartmentss NA 50% Human Human +DTXSID9025164 Css NA 7.884 mg/L 3compartmentss NA 95% Human Human +DTXSID9025164 Css NA 0.7984 mg/L PBTK NA 50% Human Human +DTXSID9025164 Css NA 4.886 mg/L PBTK NA 95% Human Human +DTXSID9025164 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025164 Fup 0.0846 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025164 Vd NA 1.172 L/kg 1compartment NA NA Rat Human DTXSID9025164 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025164 TK.Half.Life NA 5.541 hours 1compartment NA NA Rat Human -DTXSID9025164 Css NA 0.5996 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025164 Css NA 2.578 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025164 Css NA 0.3905 mg/L PBTK NA 50% Rat Human -DTXSID9025164 Css NA 1.526 mg/L PBTK NA 95% Rat Human -DTXSID9025166 Clint NA 11.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025166 Fup NA 0.1397 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025166 Vd NA 1.466 L/kg 1compartment NA NA Human Human +DTXSID9025164 TK.Half.Life NA 5.041 hours 1compartment NA NA Rat Human +DTXSID9025164 Css NA 0.149 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025164 Css NA 0.706 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025164 Css NA 0.09581 mg/L PBTK NA 50% Rat Human +DTXSID9025164 Css NA 0.423 mg/L PBTK NA 95% Rat Human +DTXSID9025166 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025166 Fup 0.0902 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025166 Vd NA 1.186 L/kg 1compartment NA NA Human Human DTXSID9025166 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025166 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human -DTXSID9025166 Css NA 0.4075 mg/L 3compartmentss NA 50% Human Human -DTXSID9025166 Css NA 2.827 mg/L 3compartmentss NA 95% Human Human -DTXSID9025166 Css NA 0.277 mg/L PBTK NA 50% Human Human -DTXSID9025166 Css NA 1.776 mg/L PBTK NA 95% Human Human -DTXSID9025166 Clint NA 11.28 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025166 Fup NA 0.1397 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025166 Vd NA 1.138 L/kg 1compartment NA NA Rat Human +DTXSID9025166 TK.Half.Life NA 8.929 hours 1compartment NA NA Human Human +DTXSID9025166 Css NA 1.063 mg/L 3compartmentss NA 50% Human Human +DTXSID9025166 Css NA 7.011 mg/L 3compartmentss NA 95% Human Human +DTXSID9025166 Css NA 0.6899 mg/L PBTK NA 50% Human Human +DTXSID9025166 Css NA 4.331 mg/L PBTK NA 95% Human Human +DTXSID9025166 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025166 Fup 0.0902 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025166 Vd NA 0.9173 L/kg 1compartment NA NA Rat Human DTXSID9025166 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025166 TK.Half.Life NA 2.04 hours 1compartment NA NA Rat Human -DTXSID9025166 Css NA 0.2186 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025166 Css NA 1.136 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025166 Css NA 0.1415 mg/L PBTK NA 50% Rat Human -DTXSID9025166 Css NA 0.6755 mg/L PBTK NA 95% Rat Human -DTXSID9025245 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025245 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025245 Vd NA 17.31 L/kg 1compartment NA NA Human Human -DTXSID9025245 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID9025245 TK.Half.Life NA 822200 hours 1compartment NA NA Human Human -DTXSID9025245 Css NA 1972 mg/L 3compartmentss NA 50% Human Human -DTXSID9025245 Css NA 4858 mg/L 3compartmentss NA 95% Human Human -DTXSID9025245 Css NA 3650 mg/L PBTK NA 50% Human Human -DTXSID9025245 Css NA 7842 mg/L PBTK NA 95% Human Human -DTXSID9025245 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025245 Fup NA 0.0228 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025245 Vd NA 13.96 L/kg 1compartment NA NA Rat Human -DTXSID9025245 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID9025245 TK.Half.Life NA 54880 hours 1compartment NA NA Rat Human -DTXSID9025245 Css NA 502.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025245 Css NA 841.5 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025245 Css NA 977.4 mg/L PBTK NA 50% Rat Human -DTXSID9025245 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID9025166 TK.Half.Life NA 3.743 hours 1compartment NA NA Rat Human +DTXSID9025166 Css NA 0.1299 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025166 Css NA 0.6486 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025166 Css NA 0.08185 mg/L PBTK NA 50% Rat Human +DTXSID9025166 Css NA 0.386 mg/L PBTK NA 95% Rat Human +DTXSID9025245 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025245 Fup 0.0194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025245 Vd NA 3.112 L/kg 1compartment NA NA Human Human +DTXSID9025245 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID9025245 TK.Half.Life NA 87.57 hours 1compartment NA NA Human Human +DTXSID9025245 Css NA 1.821 mg/L 3compartmentss NA 50% Human Human +DTXSID9025245 Css NA 12.09 mg/L 3compartmentss NA 95% Human Human +DTXSID9025245 Css NA 1.26 mg/L PBTK NA 50% Human Human +DTXSID9025245 Css NA 8.23 mg/L PBTK NA 95% Human Human +DTXSID9025245 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025245 Fup 0.0194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025245 Vd NA 2.331 L/kg 1compartment NA NA Rat Human +DTXSID9025245 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID9025245 TK.Half.Life NA 11.96 hours 1compartment NA NA Rat Human +DTXSID9025245 Css NA 0.01996 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025245 Css NA 0.1242 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025245 Css NA 0.0132 mg/L PBTK NA 50% Rat Human +DTXSID9025245 Css NA 0.08052 mg/L PBTK NA 95% Rat Human +DTXSID9025249 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025249 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025249 Vd NA 5.152 L/kg 1compartment NA NA Human Human +DTXSID9025249 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID9025249 TK.Half.Life NA 154.5 hours 1compartment NA NA Human Human +DTXSID9025249 Css NA 1.586 mg/L 3compartmentss NA 50% Human Human +DTXSID9025249 Css NA 10.05 mg/L 3compartmentss NA 95% Human Human +DTXSID9025249 Css NA 1.304 mg/L PBTK NA 50% Human Human +DTXSID9025249 Css NA 8.135 mg/L PBTK NA 95% Human Human +DTXSID9025249 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025249 Fup 0.0242 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025249 Vd NA 3.939 L/kg 1compartment NA NA Rat Human +DTXSID9025249 Days.Css NA 16 Days PBTK NA NA Rat Human +DTXSID9025249 TK.Half.Life NA 20.84 hours 1compartment NA NA Rat Human +DTXSID9025249 Css NA 0.01695 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025249 Css NA 0.103 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025249 Css NA 0.01369 mg/L PBTK NA 50% Rat Human +DTXSID9025249 Css NA 0.08243 mg/L PBTK NA 95% Rat Human DTXSID9025293 Clint 1.715 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID9025293 Fup 0.1316 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID9025293 Vd NA 0.366 L/kg 1compartment NA NA Human Human DTXSID9025293 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9025293 TK.Half.Life NA 4.857 hours 1compartment NA NA Human Human -DTXSID9025293 Css NA 1.655 mg/L 3compartmentss NA 50% Human Human -DTXSID9025293 Css NA 6.717 mg/L 3compartmentss NA 95% Human Human -DTXSID9025293 Css NA 1.081 mg/L PBTK NA 50% Human Human -DTXSID9025293 Css NA 4.196 mg/L PBTK NA 95% Human Human +DTXSID9025293 Css NA 1.607 mg/L 3compartmentss NA 50% Human Human +DTXSID9025293 Css NA 6.553 mg/L 3compartmentss NA 95% Human Human +DTXSID9025293 Css NA 1.05 mg/L PBTK NA 50% Human Human +DTXSID9025293 Css NA 4.045 mg/L PBTK NA 95% Human Human DTXSID9025293 Clint 1.715 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID9025293 Fup 0.1316 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID9025293 Vd NA 0.3553 L/kg 1compartment NA NA Rat Human DTXSID9025293 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9025293 TK.Half.Life NA 2.545 hours 1compartment NA NA Rat Human -DTXSID9025293 Css NA 0.7383 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025293 Css NA 2.158 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025293 Css NA 0.4564 mg/L PBTK NA 50% Rat Human -DTXSID9025293 Css NA 1.248 mg/L PBTK NA 95% Rat Human -DTXSID9025299 Clint NA 33.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025299 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025299 Vd NA 3.089 L/kg 1compartment NA NA Human Human -DTXSID9025299 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID9025299 TK.Half.Life NA 59.5 hours 1compartment NA NA Human Human -DTXSID9025299 Css NA 2.301 mg/L 3compartmentss NA 50% Human Human -DTXSID9025299 Css NA 13.78 mg/L 3compartmentss NA 95% Human Human -DTXSID9025299 Css NA 1.589 mg/L PBTK NA 50% Human Human -DTXSID9025299 Css NA 9.278 mg/L PBTK NA 95% Human Human -DTXSID9025299 Clint NA 33.91 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025299 Fup NA 0.0079 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025299 Vd NA 2.313 L/kg 1compartment NA NA Rat Human -DTXSID9025299 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9025299 TK.Half.Life NA 8.514 hours 1compartment NA NA Rat Human -DTXSID9025299 Css NA 1.309 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025299 Css NA 6.037 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025299 Css NA 0.8656 mg/L PBTK NA 50% Rat Human -DTXSID9025299 Css NA 3.931 mg/L PBTK NA 95% Rat Human -DTXSID9025326 Clint NA 0.000918 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025326 Fup NA 0.0925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025326 Vd NA 7.131 L/kg 1compartment NA NA Human Human -DTXSID9025326 Days.Css NA 13780 Days PBTK NA NA Human Human -DTXSID9025326 TK.Half.Life NA 315600 hours 1compartment NA NA Human Human -DTXSID9025326 Css NA 3376 mg/L 3compartmentss NA 50% Human Human -DTXSID9025326 Css NA 7876 mg/L 3compartmentss NA 95% Human Human -DTXSID9025326 Css NA 3284 mg/L PBTK NA 50% Human Human -DTXSID9025326 Css NA 7025 mg/L PBTK NA 95% Human Human -DTXSID9025326 Clint NA 0.000918 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025326 Fup NA 0.0925 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025326 Vd NA 5.53 L/kg 1compartment NA NA Rat Human -DTXSID9025326 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID9025326 TK.Half.Life NA 20670 hours 1compartment NA NA Rat Human -DTXSID9025326 Css NA 969.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025326 Css NA 1514 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025326 Css NA 929.8 mg/L PBTK NA 50% Rat Human -DTXSID9025326 Css NA 1281 mg/L PBTK NA 95% Rat Human +DTXSID9025293 Css NA 0.167 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025293 Css NA 0.4789 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025293 Css NA 0.1069 mg/L PBTK NA 50% Rat Human +DTXSID9025293 Css NA 0.2861 mg/L PBTK NA 95% Rat Human +DTXSID9025299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025299 Fup 0.00398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025299 Vd NA 3.578 L/kg 1compartment NA NA Human Human +DTXSID9025299 Days.Css NA 19 Days PBTK NA NA Human Human +DTXSID9025299 TK.Half.Life NA 110.7 hours 1compartment NA NA Human Human +DTXSID9025299 Css NA 3.345 mg/L 3compartmentss NA 50% Human Human +DTXSID9025299 Css NA 19.78 mg/L 3compartmentss NA 95% Human Human +DTXSID9025299 Css NA 2.407 mg/L PBTK NA 50% Human Human +DTXSID9025299 Css NA 14.12 mg/L PBTK NA 95% Human Human +DTXSID9025299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025299 Fup 0.00398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025299 Vd NA 2.695 L/kg 1compartment NA NA Rat Human +DTXSID9025299 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID9025299 TK.Half.Life NA 15.95 hours 1compartment NA NA Rat Human +DTXSID9025299 Css NA 0.4435 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025299 Css NA 2.229 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025299 Css NA 0.3172 mg/L PBTK NA 50% Rat Human +DTXSID9025299 Css NA 1.653 mg/L PBTK NA 95% Rat Human +DTXSID9025324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025324 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025324 Vd NA 2.899 L/kg 1compartment NA NA Human Human +DTXSID9025324 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9025324 TK.Half.Life NA 11.52 hours 1compartment NA NA Human Human +DTXSID9025324 Css NA 0.3771 mg/L 3compartmentss NA 50% Human Human +DTXSID9025324 Css NA 2.336 mg/L 3compartmentss NA 95% Human Human +DTXSID9025324 Css NA 0.2724 mg/L PBTK NA 50% Human Human +DTXSID9025324 Css NA 1.625 mg/L PBTK NA 95% Human Human +DTXSID9025324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025324 Fup 0.241 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025324 Vd NA 2.194 L/kg 1compartment NA NA Rat Human +DTXSID9025324 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9025324 TK.Half.Life NA 2.395 hours 1compartment NA NA Rat Human +DTXSID9025324 Css NA 0.04802 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025324 Css NA 0.2348 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025324 Css NA 0.03438 mg/L PBTK NA 50% Rat Human +DTXSID9025324 Css NA 0.1609 mg/L PBTK NA 95% Rat Human DTXSID9025328 Clint NA 15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9025328 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025328 Vd NA 2.387 L/kg 1compartment NA NA Human Human -DTXSID9025328 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID9025328 TK.Half.Life NA 46.24 hours 1compartment NA NA Human Human -DTXSID9025328 Css NA 2.89 mg/L 3compartmentss NA 50% Human Human -DTXSID9025328 Css NA 21.04 mg/L 3compartmentss NA 95% Human Human -DTXSID9025328 Css NA 1.891 mg/L PBTK NA 50% Human Human -DTXSID9025328 Css NA 13.26 mg/L PBTK NA 95% Human Human +DTXSID9025328 Vd NA 0.2166 L/kg 1compartment NA NA Human Human +DTXSID9025328 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9025328 TK.Half.Life NA 3.691 hours 1compartment NA NA Human Human +DTXSID9025328 Css NA 2.65 mg/L 3compartmentss NA 50% Human Human +DTXSID9025328 Css NA 25.46 mg/L 3compartmentss NA 95% Human Human +DTXSID9025328 Css NA 1.557 mg/L PBTK NA 50% Human Human +DTXSID9025328 Css NA 14.89 mg/L PBTK NA 95% Human Human DTXSID9025328 Clint NA 15 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9025328 Fup NA 0.0152 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025328 Vd NA 1.778 L/kg 1compartment NA NA Rat Human -DTXSID9025328 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9025328 TK.Half.Life NA 12.08 hours 1compartment NA NA Rat Human -DTXSID9025328 Css NA 1.613 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025328 Css NA 9.821 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025328 Css NA 1.001 mg/L PBTK NA 50% Rat Human -DTXSID9025328 Css NA 5.816 mg/L PBTK NA 95% Rat Human -DTXSID9025370 Clint NA 1.261 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025370 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025370 Vd NA 0.2016 L/kg 1compartment NA NA Human Human -DTXSID9025370 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9025370 TK.Half.Life NA 20.27 hours 1compartment NA NA Human Human -DTXSID9025370 Css NA 17.68 mg/L 3compartmentss NA 50% Human Human -DTXSID9025370 Css NA 119.4 mg/L 3compartmentss NA 95% Human Human -DTXSID9025370 Css NA 10.46 mg/L PBTK NA 50% Human Human -DTXSID9025370 Css NA 70.33 mg/L PBTK NA 95% Human Human -DTXSID9025370 Clint NA 1.261 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025370 Fup NA 0.0208 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025370 Vd NA 0.1994 L/kg 1compartment NA NA Rat Human -DTXSID9025370 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9025370 TK.Half.Life NA 10.47 hours 1compartment NA NA Rat Human -DTXSID9025370 Css NA 7.778 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025370 Css NA 46.11 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025370 Css NA 4.272 mg/L PBTK NA 50% Rat Human -DTXSID9025370 Css NA 24.96 mg/L PBTK NA 95% Rat Human -DTXSID9025401 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025401 Fup NA 0.25 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025401 Vd NA 1.433 L/kg 1compartment NA NA Human Human -DTXSID9025401 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID9025401 TK.Half.Life NA 47.09 hours 1compartment NA NA Human Human -DTXSID9025401 Css NA 3.672 mg/L 3compartmentss NA 50% Human Human -DTXSID9025401 Css NA 13.08 mg/L 3compartmentss NA 95% Human Human -DTXSID9025401 Css NA 2.705 mg/L PBTK NA 50% Human Human -DTXSID9025401 Css NA 8.491 mg/L PBTK NA 95% Human Human -DTXSID9025401 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025401 Fup NA 0.25 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025401 Vd NA 1.151 L/kg 1compartment NA NA Rat Human -DTXSID9025401 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9025401 TK.Half.Life NA 10.8 hours 1compartment NA NA Rat Human -DTXSID9025401 Css NA 0.9925 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025401 Css NA 3.022 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025401 Css NA 0.7031 mg/L PBTK NA 50% Rat Human -DTXSID9025401 Css NA 1.828 mg/L PBTK NA 95% Rat Human -DTXSID9025409 Clint NA 14.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025409 Fup NA 0.0561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025409 Vd NA 0.4738 L/kg 1compartment NA NA Human Human +DTXSID9025328 Vd NA 0.2024 L/kg 1compartment NA NA Rat Human +DTXSID9025328 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9025328 TK.Half.Life NA 2.278 hours 1compartment NA NA Rat Human +DTXSID9025328 Css NA 0.1311 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025328 Css NA 1.422 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025328 Css NA 0.07287 mg/L PBTK NA 50% Rat Human +DTXSID9025328 Css NA 0.7899 mg/L PBTK NA 95% Rat Human +DTXSID9025370 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025370 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025370 Vd NA 0.4379 L/kg 1compartment NA NA Human Human +DTXSID9025370 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9025370 TK.Half.Life NA 1.617 hours 1compartment NA NA Human Human +DTXSID9025370 Css NA 0.3687 mg/L 3compartmentss NA 50% Human Human +DTXSID9025370 Css NA 2.186 mg/L 3compartmentss NA 95% Human Human +DTXSID9025370 Css NA 0.2498 mg/L PBTK NA 50% Human Human +DTXSID9025370 Css NA 1.404 mg/L PBTK NA 95% Human Human +DTXSID9025370 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025370 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025370 Vd NA 0.4389 L/kg 1compartment NA NA Rat Human +DTXSID9025370 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9025370 TK.Half.Life NA 0.9582 hours 1compartment NA NA Rat Human +DTXSID9025370 Css NA 0.04464 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025370 Css NA 0.1862 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025370 Css NA 0.02972 mg/L PBTK NA 50% Rat Human +DTXSID9025370 Css NA 0.1146 mg/L PBTK NA 95% Rat Human +DTXSID9025401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025401 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025401 Vd NA 2.456 L/kg 1compartment NA NA Human Human +DTXSID9025401 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9025401 TK.Half.Life NA 4.472 hours 1compartment NA NA Human Human +DTXSID9025401 Css NA 0.124 mg/L 3compartmentss NA 50% Human Human +DTXSID9025401 Css NA 0.8566 mg/L 3compartmentss NA 95% Human Human +DTXSID9025401 Css NA 0.09407 mg/L PBTK NA 50% Human Human +DTXSID9025401 Css NA 0.6209 mg/L PBTK NA 95% Human Human +DTXSID9025401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025401 Fup 0.329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025401 Vd NA 1.897 L/kg 1compartment NA NA Rat Human +DTXSID9025401 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9025401 TK.Half.Life NA 1.328 hours 1compartment NA NA Rat Human +DTXSID9025401 Css NA 0.01584 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025401 Css NA 0.0809 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025401 Css NA 0.01207 mg/L PBTK NA 50% Rat Human +DTXSID9025401 Css NA 0.05725 mg/L PBTK NA 95% Rat Human +DTXSID9025403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025403 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025403 Vd NA 3.07 L/kg 1compartment NA NA Human Human +DTXSID9025403 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID9025403 TK.Half.Life NA 65.39 hours 1compartment NA NA Human Human +DTXSID9025403 Css NA 2.559 mg/L 3compartmentss NA 50% Human Human +DTXSID9025403 Css NA 17.55 mg/L 3compartmentss NA 95% Human Human +DTXSID9025403 Css NA 1.765 mg/L PBTK NA 50% Human Human +DTXSID9025403 Css NA 11.59 mg/L PBTK NA 95% Human Human +DTXSID9025403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025403 Fup 0.0313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025403 Vd NA 2.3 L/kg 1compartment NA NA Rat Human +DTXSID9025403 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID9025403 TK.Half.Life NA 9.534 hours 1compartment NA NA Rat Human +DTXSID9025403 Css NA 0.331 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025403 Css NA 1.857 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025403 Css NA 0.2263 mg/L PBTK NA 50% Rat Human +DTXSID9025403 Css NA 1.256 mg/L PBTK NA 95% Rat Human +DTXSID9025409 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025409 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025409 Vd NA 1.081 L/kg 1compartment NA NA Human Human DTXSID9025409 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025409 TK.Half.Life NA 2.519 hours 1compartment NA NA Human Human -DTXSID9025409 Css NA 0.8035 mg/L 3compartmentss NA 50% Human Human -DTXSID9025409 Css NA 6.053 mg/L 3compartmentss NA 95% Human Human -DTXSID9025409 Css NA 0.4925 mg/L PBTK NA 50% Human Human -DTXSID9025409 Css NA 3.628 mg/L PBTK NA 95% Human Human -DTXSID9025409 Clint NA 14.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025409 Fup NA 0.0561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025409 Vd NA 0.4252 L/kg 1compartment NA NA Rat Human +DTXSID9025409 TK.Half.Life NA 3.142 hours 1compartment NA NA Human Human +DTXSID9025409 Css NA 0.2589 mg/L 3compartmentss NA 50% Human Human +DTXSID9025409 Css NA 1.563 mg/L 3compartmentss NA 95% Human Human +DTXSID9025409 Css NA 0.1927 mg/L PBTK NA 50% Human Human +DTXSID9025409 Css NA 1.058 mg/L PBTK NA 95% Human Human +DTXSID9025409 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025409 Fup 0.255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025409 Vd NA 0.9847 L/kg 1compartment NA NA Rat Human DTXSID9025409 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025409 TK.Half.Life NA 1.414 hours 1compartment NA NA Rat Human -DTXSID9025409 Css NA 0.4525 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025409 Css NA 2.595 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025409 Css NA 0.26 mg/L PBTK NA 50% Rat Human -DTXSID9025409 Css NA 1.433 mg/L PBTK NA 95% Rat Human -DTXSID9025455 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025455 Fup NA 0.796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025455 Vd NA 1.289 L/kg 1compartment NA NA Human Human -DTXSID9025455 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9025455 TK.Half.Life NA 11.31 hours 1compartment NA NA Human Human -DTXSID9025455 Css NA 0.9364 mg/L 3compartmentss NA 50% Human Human -DTXSID9025455 Css NA 5.999 mg/L 3compartmentss NA 95% Human Human -DTXSID9025455 Css NA 0.8464 mg/L PBTK NA 50% Human Human -DTXSID9025455 Css NA 4.045 mg/L PBTK NA 95% Human Human -DTXSID9025455 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025455 Fup NA 0.796 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025455 Vd NA 1.186 L/kg 1compartment NA NA Rat Human +DTXSID9025409 TK.Half.Life NA 1.613 hours 1compartment NA NA Rat Human +DTXSID9025409 Css NA 0.03042 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025409 Css NA 0.1364 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025409 Css NA 0.02261 mg/L PBTK NA 50% Rat Human +DTXSID9025409 Css NA 0.08957 mg/L PBTK NA 95% Rat Human +DTXSID9025451 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025451 Fup 0.0329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025451 Vd NA 2.435 L/kg 1compartment NA NA Human Human +DTXSID9025451 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9025451 TK.Half.Life NA 21.67 hours 1compartment NA NA Human Human +DTXSID9025451 Css NA 1.206 mg/L 3compartmentss NA 50% Human Human +DTXSID9025451 Css NA 8.45 mg/L 3compartmentss NA 95% Human Human +DTXSID9025451 Css NA 0.8028 mg/L PBTK NA 50% Human Human +DTXSID9025451 Css NA 5.394 mg/L PBTK NA 95% Human Human +DTXSID9025451 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025451 Fup 0.0329 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025451 Vd NA 1.82 L/kg 1compartment NA NA Rat Human +DTXSID9025451 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9025451 TK.Half.Life NA 5.649 hours 1compartment NA NA Rat Human +DTXSID9025451 Css NA 0.1554 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025451 Css NA 0.9248 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025451 Css NA 0.1013 mg/L PBTK NA 50% Rat Human +DTXSID9025451 Css NA 0.582 mg/L PBTK NA 95% Rat Human +DTXSID9025455 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025455 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025455 Vd NA 0.8964 L/kg 1compartment NA NA Human Human +DTXSID9025455 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9025455 TK.Half.Life NA 0.8251 hours 1compartment NA NA Human Human +DTXSID9025455 Css NA 0.03378 mg/L 3compartmentss NA 50% Human Human +DTXSID9025455 Css NA 0.388 mg/L 3compartmentss NA 95% Human Human +DTXSID9025455 Css NA 0.02739 mg/L PBTK NA 50% Human Human +DTXSID9025455 Css NA 0.2675 mg/L PBTK NA 95% Human Human +DTXSID9025455 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025455 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025455 Vd NA 0.8522 L/kg 1compartment NA NA Rat Human DTXSID9025455 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025455 TK.Half.Life NA 3.347 hours 1compartment NA NA Rat Human -DTXSID9025455 Css NA 0.239 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025455 Css NA 1.503 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025455 Css NA 0.2114 mg/L PBTK NA 50% Rat Human -DTXSID9025455 Css NA 0.9294 mg/L PBTK NA 95% Rat Human +DTXSID9025455 TK.Half.Life NA 0.3901 hours 1compartment NA NA Rat Human +DTXSID9025455 Css NA 0.004149 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025455 Css NA 0.0384 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025455 Css NA 0.003406 mg/L PBTK NA 50% Rat Human +DTXSID9025455 Css NA 0.02597 mg/L PBTK NA 95% Rat Human DTXSID9025536 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9025536 Fup 0.4 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9025536 Vd NA 1.22 L/kg 1compartment NA NA Human Human DTXSID9025536 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID9025536 TK.Half.Life NA 22.36 hours 1compartment NA NA Human Human -DTXSID9025536 Css NA 1.828 mg/L 3compartmentss NA 50% Human Human -DTXSID9025536 Css NA 5.742 mg/L 3compartmentss NA 95% Human Human -DTXSID9025536 Css NA 1.458 mg/L PBTK NA 50% Human Human -DTXSID9025536 Css NA 3.985 mg/L PBTK NA 95% Human Human +DTXSID9025536 Css NA 1.779 mg/L 3compartmentss NA 50% Human Human +DTXSID9025536 Css NA 5.66 mg/L 3compartmentss NA 95% Human Human +DTXSID9025536 Css NA 1.423 mg/L PBTK NA 50% Human Human +DTXSID9025536 Css NA 3.908 mg/L PBTK NA 95% Human Human DTXSID9025536 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9025536 Fup 0.4 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9025536 Vd NA 1.043 L/kg 1compartment NA NA Rat Human DTXSID9025536 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9025536 TK.Half.Life NA 5.929 hours 1compartment NA NA Rat Human -DTXSID9025536 Css NA 0.4929 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025536 Css NA 1.249 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025536 Css NA 0.3811 mg/L PBTK NA 50% Rat Human -DTXSID9025536 Css NA 0.8111 mg/L PBTK NA 95% Rat Human -DTXSID9025538 Clint NA 0.3397 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025538 Fup NA 0.8304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025538 Vd NA 0.8816 L/kg 1compartment NA NA Human Human +DTXSID9025536 Css NA 0.1127 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025536 Css NA 0.2797 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025536 Css NA 0.09007 mg/L PBTK NA 50% Rat Human +DTXSID9025536 Css NA 0.1885 mg/L PBTK NA 95% Rat Human +DTXSID9025538 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025538 Fup 0.679 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025538 Vd NA 0.8037 L/kg 1compartment NA NA Human Human DTXSID9025538 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025538 TK.Half.Life NA 4.469 hours 1compartment NA NA Human Human -DTXSID9025538 Css NA 0.6117 mg/L 3compartmentss NA 50% Human Human -DTXSID9025538 Css NA 3.892 mg/L 3compartmentss NA 95% Human Human -DTXSID9025538 Css NA 0.502 mg/L PBTK NA 50% Human Human -DTXSID9025538 Css NA 2.528 mg/L PBTK NA 95% Human Human -DTXSID9025538 Clint NA 0.3397 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025538 Fup NA 0.8304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025538 Vd NA 0.9006 L/kg 1compartment NA NA Rat Human +DTXSID9025538 TK.Half.Life NA 7.667 hours 1compartment NA NA Human Human +DTXSID9025538 Css NA 1.092 mg/L 3compartmentss NA 50% Human Human +DTXSID9025538 Css NA 7.082 mg/L 3compartmentss NA 95% Human Human +DTXSID9025538 Css NA 0.8754 mg/L PBTK NA 50% Human Human +DTXSID9025538 Css NA 4.469 mg/L PBTK NA 95% Human Human +DTXSID9025538 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025538 Fup 0.679 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025538 Vd NA 0.817 L/kg 1compartment NA NA Rat Human DTXSID9025538 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025538 TK.Half.Life NA 1.891 hours 1compartment NA NA Rat Human -DTXSID9025538 Css NA 0.1923 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025538 Css NA 1.174 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025538 Css NA 0.1546 mg/L PBTK NA 50% Rat Human -DTXSID9025538 Css NA 0.705 mg/L PBTK NA 95% Rat Human -DTXSID9025588 Clint NA 2.502 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025588 Fup NA 0.1547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025588 Vd NA 0.672 L/kg 1compartment NA NA Human Human +DTXSID9025538 TK.Half.Life NA 2.654 hours 1compartment NA NA Rat Human +DTXSID9025538 Css NA 0.06567 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025538 Css NA 0.42 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025538 Css NA 0.05244 mg/L PBTK NA 50% Rat Human +DTXSID9025538 Css NA 0.2556 mg/L PBTK NA 95% Rat Human +DTXSID9025588 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025588 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025588 Vd NA 0.7909 L/kg 1compartment NA NA Human Human DTXSID9025588 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025588 TK.Half.Life NA 5.879 hours 1compartment NA NA Human Human -DTXSID9025588 Css NA 1.174 mg/L 3compartmentss NA 50% Human Human -DTXSID9025588 Css NA 6.648 mg/L 3compartmentss NA 95% Human Human -DTXSID9025588 Css NA 0.7718 mg/L PBTK NA 50% Human Human -DTXSID9025588 Css NA 4.043 mg/L PBTK NA 95% Human Human -DTXSID9025588 Clint NA 2.502 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025588 Fup NA 0.1547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025588 Vd NA 0.5782 L/kg 1compartment NA NA Rat Human +DTXSID9025588 TK.Half.Life NA 1.326 hours 1compartment NA NA Human Human +DTXSID9025588 Css NA 0.1093 mg/L 3compartmentss NA 50% Human Human +DTXSID9025588 Css NA 0.7793 mg/L 3compartmentss NA 95% Human Human +DTXSID9025588 Css NA 0.07561 mg/L PBTK NA 50% Human Human +DTXSID9025588 Css NA 0.5094 mg/L PBTK NA 95% Human Human +DTXSID9025588 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025588 Fup 0.195 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025588 Vd NA 0.6767 L/kg 1compartment NA NA Rat Human DTXSID9025588 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025588 TK.Half.Life NA 2.787 hours 1compartment NA NA Rat Human -DTXSID9025588 Css NA 0.5654 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025588 Css NA 2.437 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025588 Css NA 0.3515 mg/L PBTK NA 50% Rat Human -DTXSID9025588 Css NA 1.388 mg/L PBTK NA 95% Rat Human -DTXSID9025617 Clint NA 0.7468 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025617 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025617 Vd NA 2 L/kg 1compartment NA NA Human Human -DTXSID9025617 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025617 TK.Half.Life NA 6.107 hours 1compartment NA NA Human Human -DTXSID9025617 Css NA 0.3084 mg/L 3compartmentss NA 50% Human Human -DTXSID9025617 Css NA 2.349 mg/L 3compartmentss NA 95% Human Human -DTXSID9025617 Css NA 0.3125 mg/L PBTK NA 50% Human Human -DTXSID9025617 Css NA 1.705 mg/L PBTK NA 95% Human Human -DTXSID9025617 Clint NA 0.7468 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025617 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025617 Vd NA 2.028 L/kg 1compartment NA NA Rat Human +DTXSID9025588 TK.Half.Life NA 0.6178 hours 1compartment NA NA Rat Human +DTXSID9025588 Css NA 0.014 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025588 Css NA 0.07434 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025588 Css NA 0.009549 mg/L PBTK NA 50% Rat Human +DTXSID9025588 Css NA 0.04812 mg/L PBTK NA 95% Rat Human +DTXSID9025613 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025613 Fup 0.711 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025613 Vd NA 0.7328 L/kg 1compartment NA NA Human Human +DTXSID9025613 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9025613 TK.Half.Life NA 6.691 hours 1compartment NA NA Human Human +DTXSID9025613 Css NA 0.9117 mg/L 3compartmentss NA 50% Human Human +DTXSID9025613 Css NA 6.014 mg/L 3compartmentss NA 95% Human Human +DTXSID9025613 Css NA 0.7448 mg/L PBTK NA 50% Human Human +DTXSID9025613 Css NA 3.793 mg/L PBTK NA 95% Human Human +DTXSID9025613 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025613 Fup 0.711 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025613 Vd NA 0.7478 L/kg 1compartment NA NA Rat Human +DTXSID9025613 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9025613 TK.Half.Life NA 2.321 hours 1compartment NA NA Rat Human +DTXSID9025613 Css NA 0.0175 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025613 Css NA 0.1419 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025613 Css NA 0.01382 mg/L PBTK NA 50% Rat Human +DTXSID9025613 Css NA 0.09065 mg/L PBTK NA 95% Rat Human +DTXSID9025617 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025617 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025617 Vd NA 1.45 L/kg 1compartment NA NA Human Human +DTXSID9025617 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9025617 TK.Half.Life NA 15.22 hours 1compartment NA NA Human Human +DTXSID9025617 Css NA 0.894 mg/L 3compartmentss NA 50% Human Human +DTXSID9025617 Css NA 6.808 mg/L 3compartmentss NA 95% Human Human +DTXSID9025617 Css NA 0.8048 mg/L PBTK NA 50% Human Human +DTXSID9025617 Css NA 4.455 mg/L PBTK NA 95% Human Human +DTXSID9025617 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025617 Fup 0.619 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025617 Vd 1.2 1.461 L/kg 1compartment National Toxicology Program NA Rat Human DTXSID9025617 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025617 TK.Half.Life NA 2.857 hours 1compartment NA NA Rat Human -DTXSID9025617 Css NA 0.1073 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025617 Css NA 0.8199 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025617 Css NA 0.1094 mg/L PBTK NA 50% Rat Human -DTXSID9025617 Css NA 0.5237 mg/L PBTK NA 95% Rat Human -DTXSID9025665 Clint NA 0.3189 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025665 Fup NA 0.5071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025665 Vd NA 0.4562 L/kg 1compartment NA NA Human Human +DTXSID9025617 TK.Half.Life 0.81 5.208 hours 1compartment National Toxicology Program NA Rat Human +DTXSID9025617 Css 0.04 0.01731 mg/L 3compartmentss National Toxicology Program 50% Rat Human +DTXSID9025617 Css 0.04 0.1586 mg/L 3compartmentss National Toxicology Program 95% Rat Human +DTXSID9025617 Css 0.04 0.0151 mg/L PBTK National Toxicology Program 50% Rat Human +DTXSID9025617 Css 0.04 0.1055 mg/L PBTK National Toxicology Program 95% Rat Human +DTXSID9025665 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025665 Fup 0.546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025665 Vd NA 0.6002 L/kg 1compartment NA NA Human Human DTXSID9025665 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025665 TK.Half.Life NA 3.853 hours 1compartment NA NA Human Human -DTXSID9025665 Css NA 0.9735 mg/L 3compartmentss NA 50% Human Human -DTXSID9025665 Css NA 5.078 mg/L 3compartmentss NA 95% Human Human -DTXSID9025665 Css NA 0.7024 mg/L PBTK NA 50% Human Human -DTXSID9025665 Css NA 3.166 mg/L PBTK NA 95% Human Human -DTXSID9025665 Clint NA 0.3189 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025665 Fup NA 0.5071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025665 Vd NA 0.4684 L/kg 1compartment NA NA Rat Human +DTXSID9025665 TK.Half.Life NA 7.122 hours 1compartment NA NA Human Human +DTXSID9025665 Css NA 1.326 mg/L 3compartmentss NA 50% Human Human +DTXSID9025665 Css NA 8.409 mg/L 3compartmentss NA 95% Human Human +DTXSID9025665 Css NA 1.02 mg/L PBTK NA 50% Human Human +DTXSID9025665 Css NA 5.266 mg/L PBTK NA 95% Human Human +DTXSID9025665 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025665 Fup 0.546 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025665 Vd NA 0.6167 L/kg 1compartment NA NA Rat Human DTXSID9025665 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025665 TK.Half.Life NA 1.628 hours 1compartment NA NA Rat Human -DTXSID9025665 Css NA 0.3316 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025665 Css NA 1.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025665 Css NA 0.2265 mg/L PBTK NA 50% Rat Human -DTXSID9025665 Css NA 0.8639 mg/L PBTK NA 95% Rat Human -DTXSID9025740 Clint NA 1.715 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025740 Fup NA 0.3349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025740 Vd NA 0.9555 L/kg 1compartment NA NA Human Human +DTXSID9025665 TK.Half.Life NA 2.491 hours 1compartment NA NA Rat Human +DTXSID9025665 Css NA 0.08211 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025665 Css NA 0.4639 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025665 Css NA 0.0627 mg/L PBTK NA 50% Rat Human +DTXSID9025665 Css NA 0.2806 mg/L PBTK NA 95% Rat Human +DTXSID9025740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025740 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025740 Vd NA 0.5749 L/kg 1compartment NA NA Human Human DTXSID9025740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025740 TK.Half.Life NA 5.488 hours 1compartment NA NA Human Human -DTXSID9025740 Css NA 0.6094 mg/L 3compartmentss NA 50% Human Human -DTXSID9025740 Css NA 3.056 mg/L 3compartmentss NA 95% Human Human -DTXSID9025740 Css NA 0.4499 mg/L PBTK NA 50% Human Human -DTXSID9025740 Css NA 1.993 mg/L PBTK NA 95% Human Human -DTXSID9025740 Clint NA 1.715 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025740 Fup NA 0.3349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025740 Vd NA 0.8088 L/kg 1compartment NA NA Rat Human +DTXSID9025740 TK.Half.Life NA 1.483 hours 1compartment NA NA Human Human +DTXSID9025740 Css NA 0.2825 mg/L 3compartmentss NA 50% Human Human +DTXSID9025740 Css NA 2.312 mg/L 3compartmentss NA 95% Human Human +DTXSID9025740 Css NA 0.1759 mg/L PBTK NA 50% Human Human +DTXSID9025740 Css NA 1.396 mg/L PBTK NA 95% Human Human +DTXSID9025740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025740 Fup 0.1 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025740 Vd NA 0.4753 L/kg 1compartment NA NA Rat Human DTXSID9025740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025740 TK.Half.Life NA 2.325 hours 1compartment NA NA Rat Human -DTXSID9025740 Css NA 0.2691 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025740 Css NA 1.019 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025740 Css NA 0.1914 mg/L PBTK NA 50% Rat Human -DTXSID9025740 Css NA 0.6229 mg/L PBTK NA 95% Rat Human -DTXSID9025742 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025742 Fup NA 0.2885 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025742 Vd NA 0.6738 L/kg 1compartment NA NA Human Human -DTXSID9025742 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9025742 TK.Half.Life NA 15.66 hours 1compartment NA NA Human Human -DTXSID9025742 Css NA 2.692 mg/L 3compartmentss NA 50% Human Human -DTXSID9025742 Css NA 10.74 mg/L 3compartmentss NA 95% Human Human -DTXSID9025742 Css NA 1.895 mg/L PBTK NA 50% Human Human -DTXSID9025742 Css NA 6.702 mg/L PBTK NA 95% Human Human -DTXSID9025742 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025742 Fup NA 0.2885 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025742 Vd NA 0.5947 L/kg 1compartment NA NA Rat Human +DTXSID9025740 TK.Half.Life NA 0.7134 hours 1compartment NA NA Rat Human +DTXSID9025740 Css NA 0.03666 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025740 Css NA 0.2406 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025740 Css NA 0.02227 mg/L PBTK NA 50% Rat Human +DTXSID9025740 Css NA 0.1401 mg/L PBTK NA 95% Rat Human +DTXSID9025742 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025742 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025742 Vd NA 0.4377 L/kg 1compartment NA NA Human Human +DTXSID9025742 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9025742 TK.Half.Life NA 1.008 hours 1compartment NA NA Human Human +DTXSID9025742 Css NA 0.2312 mg/L 3compartmentss NA 50% Human Human +DTXSID9025742 Css NA 1.918 mg/L 3compartmentss NA 95% Human Human +DTXSID9025742 Css NA 0.1454 mg/L PBTK NA 50% Human Human +DTXSID9025742 Css NA 1.136 mg/L PBTK NA 95% Human Human +DTXSID9025742 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025742 Fup 0.119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025742 Vd NA 0.3849 L/kg 1compartment NA NA Rat Human DTXSID9025742 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025742 TK.Half.Life NA 4.584 hours 1compartment NA NA Rat Human -DTXSID9025742 Css NA 0.7482 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025742 Css NA 2.412 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025742 Css NA 0.5013 mg/L PBTK NA 50% Rat Human -DTXSID9025742 Css NA 1.414 mg/L PBTK NA 95% Rat Human -DTXSID9025744 Clint NA 5.422 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025744 Fup NA 0.2569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025744 Vd NA 1.949 L/kg 1compartment NA NA Human Human +DTXSID9025742 TK.Half.Life NA 0.5131 hours 1compartment NA NA Rat Human +DTXSID9025742 Css NA 0.03044 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025742 Css NA 0.186 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025742 Css NA 0.01854 mg/L PBTK NA 50% Rat Human +DTXSID9025742 Css NA 0.1079 mg/L PBTK NA 95% Rat Human +DTXSID9025744 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025744 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025744 Vd NA 1.322 L/kg 1compartment NA NA Human Human DTXSID9025744 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025744 TK.Half.Life NA 8.417 hours 1compartment NA NA Human Human -DTXSID9025744 Css NA 0.4324 mg/L 3compartmentss NA 50% Human Human -DTXSID9025744 Css NA 2.319 mg/L 3compartmentss NA 95% Human Human -DTXSID9025744 Css NA 0.3232 mg/L PBTK NA 50% Human Human -DTXSID9025744 Css NA 1.624 mg/L PBTK NA 95% Human Human -DTXSID9025744 Clint NA 5.422 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025744 Fup NA 0.2569 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025744 Vd NA 1.522 L/kg 1compartment NA NA Rat Human +DTXSID9025744 TK.Half.Life NA 3.487 hours 1compartment NA NA Human Human +DTXSID9025744 Css NA 0.279 mg/L 3compartmentss NA 50% Human Human +DTXSID9025744 Css NA 2.1 mg/L 3compartmentss NA 95% Human Human +DTXSID9025744 Css NA 0.1841 mg/L PBTK NA 50% Human Human +DTXSID9025744 Css NA 1.313 mg/L PBTK NA 95% Human Human +DTXSID9025744 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025744 Fup 0.106 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025744 Vd NA 1.021 L/kg 1compartment NA NA Rat Human DTXSID9025744 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025744 TK.Half.Life NA 2.857 hours 1compartment NA NA Rat Human -DTXSID9025744 Css NA 0.219 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025744 Css NA 0.8707 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025744 Css NA 0.1577 mg/L PBTK NA 50% Rat Human -DTXSID9025744 Css NA 0.5624 mg/L PBTK NA 95% Rat Human -DTXSID9025746 Clint NA 1.405 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025746 Fup NA 0.0602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025746 Vd NA 2.572 L/kg 1compartment NA NA Human Human -DTXSID9025746 Days.Css NA 39 Days PBTK NA NA Human Human -DTXSID9025746 TK.Half.Life NA 192.5 hours 1compartment NA NA Human Human -DTXSID9025746 Css NA 10.33 mg/L 3compartmentss NA 50% Human Human -DTXSID9025746 Css NA 42.72 mg/L 3compartmentss NA 95% Human Human -DTXSID9025746 Css NA 7.034 mg/L PBTK NA 50% Human Human -DTXSID9025746 Css NA 27.79 mg/L PBTK NA 95% Human Human -DTXSID9025746 Clint NA 1.405 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025746 Fup NA 0.0602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025746 Vd NA 1.929 L/kg 1compartment NA NA Rat Human -DTXSID9025746 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID9025746 TK.Half.Life NA 37.98 hours 1compartment NA NA Rat Human -DTXSID9025746 Css NA 4.833 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025746 Css NA 14.3 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025746 Css NA 3.12 mg/L PBTK NA 50% Rat Human -DTXSID9025746 Css NA 8.553 mg/L PBTK NA 95% Rat Human -DTXSID9025825 Clint NA 2006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025825 Fup NA 0.0376 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025825 Vd NA 1.187 L/kg 1compartment NA NA Human Human +DTXSID9025744 TK.Half.Life NA 1.413 hours 1compartment NA NA Rat Human +DTXSID9025744 Css NA 0.03568 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025744 Css NA 0.2193 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025744 Css NA 0.02303 mg/L PBTK NA 50% Rat Human +DTXSID9025744 Css NA 0.1347 mg/L PBTK NA 95% Rat Human +DTXSID9025746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025746 Fup 0.0194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025746 Vd NA 1.895 L/kg 1compartment NA NA Human Human +DTXSID9025746 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9025746 TK.Half.Life NA 19.2 hours 1compartment NA NA Human Human +DTXSID9025746 Css NA 1.511 mg/L 3compartmentss NA 50% Human Human +DTXSID9025746 Css NA 12.74 mg/L 3compartmentss NA 95% Human Human +DTXSID9025746 Css NA 0.9662 mg/L PBTK NA 50% Human Human +DTXSID9025746 Css NA 7.82 mg/L PBTK NA 95% Human Human +DTXSID9025746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025746 Fup 0.0194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025746 Vd NA 1.407 L/kg 1compartment NA NA Rat Human +DTXSID9025746 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9025746 TK.Half.Life NA 6.442 hours 1compartment NA NA Rat Human +DTXSID9025746 Css NA 0.1958 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025746 Css NA 1.324 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025746 Css NA 0.122 mg/L PBTK NA 50% Rat Human +DTXSID9025746 Css NA 0.7829 mg/L PBTK NA 95% Rat Human +DTXSID9025825 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025825 Fup 0.0758 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025825 Vd NA 2.121 L/kg 1compartment NA NA Human Human DTXSID9025825 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9025825 TK.Half.Life NA 1.131 hours 1compartment NA NA Human Human -DTXSID9025825 Css NA 0.00925 mg/L 3compartmentss NA 50% Human Human -DTXSID9025825 Css NA 0.08751 mg/L 3compartmentss NA 95% Human Human -DTXSID9025825 Css NA 0.00576 mg/L PBTK NA 50% Human Human -DTXSID9025825 Css NA 0.05218 mg/L PBTK NA 95% Human Human -DTXSID9025825 Clint NA 2006 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025825 Fup NA 0.0376 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025825 Vd NA 0.8981 L/kg 1compartment NA NA Rat Human +DTXSID9025825 TK.Half.Life NA 8.927 hours 1compartment NA NA Human Human +DTXSID9025825 Css NA 0.4955 mg/L 3compartmentss NA 50% Human Human +DTXSID9025825 Css NA 3.356 mg/L 3compartmentss NA 95% Human Human +DTXSID9025825 Css NA 0.3345 mg/L PBTK NA 50% Human Human +DTXSID9025825 Css NA 2.159 mg/L PBTK NA 95% Human Human +DTXSID9025825 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025825 Fup 0.0758 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025825 Vd NA 1.605 L/kg 1compartment NA NA Rat Human DTXSID9025825 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025825 TK.Half.Life NA 0.3819 hours 1compartment NA NA Rat Human -DTXSID9025825 Css NA 0.005332 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025825 Css NA 0.04321 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025825 Css NA 0.003128 mg/L PBTK NA 50% Rat Human -DTXSID9025825 Css NA 0.02443 mg/L PBTK NA 95% Rat Human -DTXSID9025873 Clint NA 0.2502 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025873 Fup NA 0.1918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025873 Vd NA 0.4001 L/kg 1compartment NA NA Human Human +DTXSID9025825 TK.Half.Life NA 2.837 hours 1compartment NA NA Rat Human +DTXSID9025825 Css NA 0.06422 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025825 Css NA 0.3446 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025825 Css NA 0.0423 mg/L PBTK NA 50% Rat Human +DTXSID9025825 Css NA 0.2214 mg/L PBTK NA 95% Rat Human +DTXSID9025873 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025873 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025873 Vd NA 0.5393 L/kg 1compartment NA NA Human Human DTXSID9025873 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9025873 TK.Half.Life NA 9.544 hours 1compartment NA NA Human Human -DTXSID9025873 Css NA 2.808 mg/L 3compartmentss NA 50% Human Human -DTXSID9025873 Css NA 10.86 mg/L 3compartmentss NA 95% Human Human -DTXSID9025873 Css NA 1.888 mg/L PBTK NA 50% Human Human -DTXSID9025873 Css NA 6.652 mg/L PBTK NA 95% Human Human -DTXSID9025873 Clint NA 0.2502 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025873 Fup NA 0.1918 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025873 Vd NA 0.4005 L/kg 1compartment NA NA Rat Human +DTXSID9025873 TK.Half.Life NA 10.26 hours 1compartment NA NA Human Human +DTXSID9025873 Css NA 2.042 mg/L 3compartmentss NA 50% Human Human +DTXSID9025873 Css NA 8.522 mg/L 3compartmentss NA 95% Human Human +DTXSID9025873 Css NA 1.521 mg/L PBTK NA 50% Human Human +DTXSID9025873 Css NA 5.461 mg/L PBTK NA 95% Human Human +DTXSID9025873 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025873 Fup 0.34 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025873 Vd NA 0.5424 L/kg 1compartment NA NA Rat Human DTXSID9025873 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025873 TK.Half.Life NA 3.832 hours 1compartment NA NA Rat Human -DTXSID9025873 Css NA 0.9445 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025873 Css NA 2.971 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025873 Css NA 0.6008 mg/L PBTK NA 50% Rat Human -DTXSID9025873 Css NA 1.707 mg/L PBTK NA 95% Rat Human -DTXSID9025879 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025879 Fup NA 0.0908 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9025879 Vd NA 0.333 L/kg 1compartment NA NA Human Human -DTXSID9025879 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9025879 TK.Half.Life NA 23.73 hours 1compartment NA NA Human Human -DTXSID9025879 Css NA 11.05 mg/L 3compartmentss NA 50% Human Human -DTXSID9025879 Css NA 51.27 mg/L 3compartmentss NA 95% Human Human -DTXSID9025879 Css NA 6.942 mg/L PBTK NA 50% Human Human -DTXSID9025879 Css NA 30.29 mg/L PBTK NA 95% Human Human -DTXSID9025879 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025879 Fup NA 0.0908 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9025879 Vd NA 0.329 L/kg 1compartment NA NA Rat Human +DTXSID9025873 TK.Half.Life NA 3.517 hours 1compartment NA NA Rat Human +DTXSID9025873 Css NA 0.131 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025873 Css NA 0.4576 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025873 Css NA 0.09601 mg/L PBTK NA 50% Rat Human +DTXSID9025873 Css NA 0.283 mg/L PBTK NA 95% Rat Human +DTXSID9025879 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025879 Fup 0.0871 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9025879 Vd NA 0.3433 L/kg 1compartment NA NA Human Human +DTXSID9025879 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9025879 TK.Half.Life NA 0.98 hours 1compartment NA NA Human Human +DTXSID9025879 Css NA 0.3312 mg/L 3compartmentss NA 50% Human Human +DTXSID9025879 Css NA 2.679 mg/L 3compartmentss NA 95% Human Human +DTXSID9025879 Css NA 0.2088 mg/L PBTK NA 50% Human Human +DTXSID9025879 Css NA 1.622 mg/L PBTK NA 95% Human Human +DTXSID9025879 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025879 Fup 0.0871 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9025879 Vd NA 0.3384 L/kg 1compartment NA NA Rat Human DTXSID9025879 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9025879 TK.Half.Life NA 7.987 hours 1compartment NA NA Rat Human -DTXSID9025879 Css NA 3.124 mg/L 3compartmentss NA 50% Rat Human -DTXSID9025879 Css NA 12.24 mg/L 3compartmentss NA 95% Rat Human -DTXSID9025879 Css NA 1.834 mg/L PBTK NA 50% Rat Human -DTXSID9025879 Css NA 6.765 mg/L PBTK NA 95% Rat Human -DTXSID9026051 Clint NA 0.9309 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026051 Fup NA 0.2076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026051 Vd NA 2.586 L/kg 1compartment NA NA Human Human -DTXSID9026051 Days.Css NA 14 Days PBTK NA NA Human Human -DTXSID9026051 TK.Half.Life NA 87.22 hours 1compartment NA NA Human Human -DTXSID9026051 Css NA 3.825 mg/L 3compartmentss NA 50% Human Human -DTXSID9026051 Css NA 13.43 mg/L 3compartmentss NA 95% Human Human -DTXSID9026051 Css NA 2.786 mg/L PBTK NA 50% Human Human -DTXSID9026051 Css NA 8.996 mg/L PBTK NA 95% Human Human -DTXSID9026051 Clint NA 0.9309 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026051 Fup NA 0.2076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026051 Vd NA 1.967 L/kg 1compartment NA NA Rat Human -DTXSID9026051 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID9026051 TK.Half.Life NA 16.27 hours 1compartment NA NA Rat Human -DTXSID9026051 Css NA 1.591 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026051 Css NA 4.104 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026051 Css NA 1.113 mg/L PBTK NA 50% Rat Human -DTXSID9026051 Css NA 2.559 mg/L PBTK NA 95% Rat Human +DTXSID9025879 TK.Half.Life NA 0.5825 hours 1compartment NA NA Rat Human +DTXSID9025879 Css NA 0.0433 mg/L 3compartmentss NA 50% Rat Human +DTXSID9025879 Css NA 0.2721 mg/L 3compartmentss NA 95% Rat Human +DTXSID9025879 Css NA 0.02647 mg/L PBTK NA 50% Rat Human +DTXSID9025879 Css NA 0.1595 mg/L PBTK NA 95% Rat Human DTXSID9026053 Clint NA 16.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9026053 Fup NA 0.9473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026053 Vd NA 0.9685 L/kg 1compartment NA NA Human Human +DTXSID9026053 Vd NA 0.4825 L/kg 1compartment NA NA Human Human DTXSID9026053 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026053 TK.Half.Life NA 0.7114 hours 1compartment NA NA Human Human -DTXSID9026053 Css NA 0.02984 mg/L 3compartmentss NA 50% Human Human -DTXSID9026053 Css NA 0.2154 mg/L 3compartmentss NA 95% Human Human -DTXSID9026053 Css NA 0.02575 mg/L PBTK NA 50% Human Human -DTXSID9026053 Css NA 0.1654 mg/L PBTK NA 95% Human Human +DTXSID9026053 TK.Half.Life NA 0.384 hours 1compartment NA NA Human Human +DTXSID9026053 Css NA 0.01924 mg/L 3compartmentss NA 50% Human Human +DTXSID9026053 Css NA 0.1642 mg/L 3compartmentss NA 95% Human Human +DTXSID9026053 Css NA 0.01412 mg/L PBTK NA 50% Human Human +DTXSID9026053 Css NA 0.1126 mg/L PBTK NA 95% Human Human DTXSID9026053 Clint NA 16.06 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9026053 Fup NA 0.9473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026053 Vd NA 1.002 L/kg 1compartment NA NA Rat Human +DTXSID9026053 Vd NA 0.5119 L/kg 1compartment NA NA Rat Human DTXSID9026053 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026053 TK.Half.Life NA 0.361 hours 1compartment NA NA Rat Human -DTXSID9026053 Css NA 0.01496 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026053 Css NA 0.08341 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026053 Css NA 0.01302 mg/L PBTK NA 50% Rat Human -DTXSID9026053 Css NA 0.06416 mg/L PBTK NA 95% Rat Human +DTXSID9026053 TK.Half.Life NA 0.1918 hours 1compartment NA NA Rat Human +DTXSID9026053 Css NA 0.0006759 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026053 Css NA 0.006035 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026053 Css NA 0.0004906 mg/L PBTK NA 50% Rat Human +DTXSID9026053 Css NA 0.004071 mg/L PBTK NA 95% Rat Human DTXSID9026059 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9026059 Fup NA 0.9936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9026059 Vd NA 0.7869 L/kg 1compartment NA NA Human Human DTXSID9026059 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9026059 TK.Half.Life NA 5.127 hours 1compartment NA NA Human Human -DTXSID9026059 Css NA 0.8546 mg/L 3compartmentss NA 50% Human Human -DTXSID9026059 Css NA 5.202 mg/L 3compartmentss NA 95% Human Human -DTXSID9026059 Css NA 0.7188 mg/L PBTK NA 50% Human Human -DTXSID9026059 Css NA 3.379 mg/L PBTK NA 95% Human Human +DTXSID9026059 Css NA 0.736 mg/L 3compartmentss NA 50% Human Human +DTXSID9026059 Css NA 4.405 mg/L 3compartmentss NA 95% Human Human +DTXSID9026059 Css NA 0.6177 mg/L PBTK NA 50% Human Human +DTXSID9026059 Css NA 2.869 mg/L PBTK NA 95% Human Human DTXSID9026059 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9026059 Fup NA 0.9936 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9026059 Vd NA 0.8229 L/kg 1compartment NA NA Rat Human DTXSID9026059 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9026059 TK.Half.Life NA 1.826 hours 1compartment NA NA Rat Human -DTXSID9026059 Css NA 0.2183 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026059 Css NA 1.248 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026059 Css NA 0.1789 mg/L PBTK NA 50% Rat Human -DTXSID9026059 Css NA 0.7565 mg/L PBTK NA 95% Rat Human +DTXSID9026059 Css NA 0.01348 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026059 Css NA 0.1022 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026059 Css NA 0.01096 mg/L PBTK NA 50% Rat Human +DTXSID9026059 Css NA 0.06732 mg/L PBTK NA 95% Rat Human DTXSID9026132 Clint 396 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9026132 Fup 0.955 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9026132 Vd NA 0.7904 L/kg 1compartment NA NA Human Human DTXSID9026132 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9026132 TK.Half.Life NA 0.451 hours 1compartment NA NA Human Human -DTXSID9026132 Css NA 0.001271 mg/L 3compartmentss NA 50% Human Human -DTXSID9026132 Css NA 0.01054 mg/L 3compartmentss NA 95% Human Human -DTXSID9026132 Css NA 0.00106 mg/L PBTK NA 50% Human Human -DTXSID9026132 Css NA 0.008265 mg/L PBTK NA 95% Human Human +DTXSID9026132 Css NA 0.0005046 mg/L 3compartmentss NA 50% Human Human +DTXSID9026132 Css NA 0.008711 mg/L 3compartmentss NA 95% Human Human +DTXSID9026132 Css NA 0.0004238 mg/L PBTK NA 50% Human Human +DTXSID9026132 Css NA 0.007009 mg/L PBTK NA 95% Human Human DTXSID9026132 Clint 396 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9026132 Fup 0.955 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9026132 Vd NA 0.8223 L/kg 1compartment NA NA Rat Human DTXSID9026132 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9026132 TK.Half.Life NA 0.2027 hours 1compartment NA NA Rat Human -DTXSID9026132 Css NA 0.0006824 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026132 Css NA 0.004516 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026132 Css NA 0.0005663 mg/L PBTK NA 50% Rat Human -DTXSID9026132 Css NA 0.003407 mg/L PBTK NA 95% Rat Human -DTXSID9026219 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026219 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026219 Vd NA 47.93 L/kg 1compartment NA NA Human Human -DTXSID9026219 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID9026219 TK.Half.Life NA 66080 hours 1compartment NA NA Human Human -DTXSID9026219 Css NA 30.25 mg/L 3compartmentss NA 50% Human Human -DTXSID9026219 Css NA 454.9 mg/L 3compartmentss NA 95% Human Human -DTXSID9026219 Css NA 135.5 mg/L PBTK NA 50% Human Human -DTXSID9026219 Css NA 692.5 mg/L PBTK NA 95% Human Human -DTXSID9026219 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026219 Fup NA 0.0062 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026219 Vd NA 40.42 L/kg 1compartment NA NA Rat Human -DTXSID9026219 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID9026219 TK.Half.Life NA 15470 hours 1compartment NA NA Rat Human -DTXSID9026219 Css NA 7.517 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026219 Css NA 108.1 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026219 Css NA 35.73 mg/L PBTK NA 50% Rat Human -DTXSID9026219 Css NA 160 mg/L PBTK NA 95% Rat Human +DTXSID9026132 Css NA 7.189e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026132 Css NA 0.0008596 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026132 Css NA 6.314e-05 mg/L PBTK NA 50% Rat Human +DTXSID9026132 Css NA 0.000678 mg/L PBTK NA 95% Rat Human +DTXSID9026219 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026219 Fup 0.0792 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026219 Vd NA 0.2375 L/kg 1compartment NA NA Human Human +DTXSID9026219 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9026219 TK.Half.Life NA 0.7356 hours 1compartment NA NA Human Human +DTXSID9026219 Css NA 0.379 mg/L 3compartmentss NA 50% Human Human +DTXSID9026219 Css NA 3.074 mg/L 3compartmentss NA 95% Human Human +DTXSID9026219 Css NA 0.2292 mg/L PBTK NA 50% Human Human +DTXSID9026219 Css NA 1.805 mg/L PBTK NA 95% Human Human +DTXSID9026219 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026219 Fup 0.0792 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026219 Vd NA 0.235 L/kg 1compartment NA NA Rat Human +DTXSID9026219 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9026219 TK.Half.Life NA 0.4409 hours 1compartment NA NA Rat Human +DTXSID9026219 Css NA 0.05028 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026219 Css NA 0.3004 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026219 Css NA 0.02936 mg/L PBTK NA 50% Rat Human +DTXSID9026219 Css NA 0.1713 mg/L PBTK NA 95% Rat Human DTXSID9026261 Clint 5.092 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9026261 Fup 0.01078 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9026261 Vd NA 1.352 L/kg 1compartment NA NA Human Human DTXSID9026261 Days.Css NA 13 Days PBTK NA NA Human Human DTXSID9026261 TK.Half.Life NA 73.79 hours 1compartment NA NA Human Human -DTXSID9026261 Css NA 9.46 mg/L 3compartmentss NA 50% Human Human -DTXSID9026261 Css NA 74.12 mg/L 3compartmentss NA 95% Human Human -DTXSID9026261 Css NA 5.824 mg/L PBTK NA 50% Human Human -DTXSID9026261 Css NA 44.2 mg/L PBTK NA 95% Human Human +DTXSID9026261 Css NA 9.263 mg/L 3compartmentss NA 50% Human Human +DTXSID9026261 Css NA 71.47 mg/L 3compartmentss NA 95% Human Human +DTXSID9026261 Css NA 5.696 mg/L PBTK NA 50% Human Human +DTXSID9026261 Css NA 42.38 mg/L PBTK NA 95% Human Human DTXSID9026261 Clint 5.092 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9026261 Fup 0.01078 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9026261 Vd NA 0.9971 L/kg 1compartment NA NA Rat Human DTXSID9026261 Days.Css NA 6 Days PBTK NA NA Rat Human DTXSID9026261 TK.Half.Life NA 28.5 hours 1compartment NA NA Rat Human -DTXSID9026261 Css NA 5.061 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026261 Css NA 32.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026261 Css NA 2.934 mg/L PBTK NA 50% Rat Human -DTXSID9026261 Css NA 18.05 mg/L PBTK NA 95% Rat Human -DTXSID9026265 Clint NA 220.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026265 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026265 Vd NA 89.91 L/kg 1compartment NA NA Human Human -DTXSID9026265 Days.Css NA 53 Days PBTK NA NA Human Human -DTXSID9026265 TK.Half.Life NA 272.6 hours 1compartment NA NA Human Human -DTXSID9026265 Css NA 0.0234 mg/L 3compartmentss NA 50% Human Human -DTXSID9026265 Css NA 0.1415 mg/L 3compartmentss NA 95% Human Human -DTXSID9026265 Css NA 0.2487 mg/L PBTK NA 50% Human Human -DTXSID9026265 Css NA 1.454 mg/L PBTK NA 95% Human Human -DTXSID9026265 Clint NA 220.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026265 Fup NA 0.0035 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026265 Vd NA 77.43 L/kg 1compartment NA NA Rat Human -DTXSID9026265 Days.Css NA 36 Days PBTK NA NA Rat Human -DTXSID9026265 TK.Half.Life NA 44.98 hours 1compartment NA NA Rat Human -DTXSID9026265 Css NA 0.01204 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026265 Css NA 0.05049 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026265 Css NA 0.1354 mg/L PBTK NA 50% Rat Human -DTXSID9026265 Css NA 0.5744 mg/L PBTK NA 95% Rat Human -DTXSID9026267 Clint NA 1441 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026267 Fup NA 0.0031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026267 Vd NA 17.72 L/kg 1compartment NA NA Human Human -DTXSID9026267 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026267 TK.Half.Life NA 13.19 hours 1compartment NA NA Human Human -DTXSID9026267 Css NA 0.02019 mg/L 3compartmentss NA 50% Human Human -DTXSID9026267 Css NA 0.1183 mg/L 3compartmentss NA 95% Human Human -DTXSID9026267 Css NA 0.03825 mg/L PBTK NA 50% Human Human -DTXSID9026267 Css NA 0.2107 mg/L PBTK NA 95% Human Human -DTXSID9026267 Clint NA 1441 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026267 Fup NA 0.0031 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026267 Vd NA 14.31 L/kg 1compartment NA NA Rat Human -DTXSID9026267 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026267 TK.Half.Life NA 3.04 hours 1compartment NA NA Rat Human -DTXSID9026267 Css NA 0.0107 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026267 Css NA 0.04632 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026267 Css NA 0.02065 mg/L PBTK NA 50% Rat Human -DTXSID9026267 Css NA 0.09017 mg/L PBTK NA 95% Rat Human -DTXSID9026342 Clint NA 4.892 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026342 Fup NA 0.5201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026342 Vd NA 1.323 L/kg 1compartment NA NA Human Human +DTXSID9026261 Css NA 1.163 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026261 Css NA 7.215 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026261 Css NA 0.6926 mg/L PBTK NA 50% Rat Human +DTXSID9026261 Css NA 4.138 mg/L PBTK NA 95% Rat Human +DTXSID9026265 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026265 Fup 0.0581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026265 Vd NA 3.133 L/kg 1compartment NA NA Human Human +DTXSID9026265 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID9026265 TK.Half.Life NA 92.93 hours 1compartment NA NA Human Human +DTXSID9026265 Css NA 3.412 mg/L 3compartmentss NA 50% Human Human +DTXSID9026265 Css NA 19.43 mg/L 3compartmentss NA 95% Human Human +DTXSID9026265 Css NA 2.377 mg/L PBTK NA 50% Human Human +DTXSID9026265 Css NA 13.51 mg/L PBTK NA 95% Human Human +DTXSID9026265 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026265 Fup 0.0581 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026265 Vd NA 2.348 L/kg 1compartment NA NA Rat Human +DTXSID9026265 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID9026265 TK.Half.Life NA 12.26 hours 1compartment NA NA Rat Human +DTXSID9026265 Css NA 0.4476 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026265 Css NA 2.292 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026265 Css NA 0.3078 mg/L PBTK NA 50% Rat Human +DTXSID9026265 Css NA 1.582 mg/L PBTK NA 95% Rat Human +DTXSID9026342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026342 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026342 Vd NA 1.112 L/kg 1compartment NA NA Human Human DTXSID9026342 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026342 TK.Half.Life NA 2.561 hours 1compartment NA NA Human Human -DTXSID9026342 Css NA 0.1549 mg/L 3compartmentss NA 50% Human Human -DTXSID9026342 Css NA 1.164 mg/L 3compartmentss NA 95% Human Human -DTXSID9026342 Css NA 0.1321 mg/L PBTK NA 50% Human Human -DTXSID9026342 Css NA 0.815 mg/L PBTK NA 95% Human Human -DTXSID9026342 Clint NA 4.892 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026342 Fup NA 0.5201 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026342 Vd NA 1.215 L/kg 1compartment NA NA Rat Human +DTXSID9026342 TK.Half.Life NA 1.237 hours 1compartment NA NA Human Human +DTXSID9026342 Css NA 0.0495 mg/L 3compartmentss NA 50% Human Human +DTXSID9026342 Css NA 0.3939 mg/L 3compartmentss NA 95% Human Human +DTXSID9026342 Css NA 0.03892 mg/L PBTK NA 50% Human Human +DTXSID9026342 Css NA 0.2763 mg/L PBTK NA 95% Human Human +DTXSID9026342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026342 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026342 Vd NA 1.018 L/kg 1compartment NA NA Rat Human DTXSID9026342 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026342 TK.Half.Life NA 1.251 hours 1compartment NA NA Rat Human -DTXSID9026342 Css NA 0.07561 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026342 Css NA 0.4607 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026342 Css NA 0.06228 mg/L PBTK NA 50% Rat Human -DTXSID9026342 Css NA 0.2961 mg/L PBTK NA 95% Rat Human -DTXSID9026558 Clint NA 7.295 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026558 Fup NA 0.5463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026558 Vd NA 1.131 L/kg 1compartment NA NA Human Human +DTXSID9026342 TK.Half.Life NA 0.5805 hours 1compartment NA NA Rat Human +DTXSID9026342 Css NA 0.005944 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026342 Css NA 0.03842 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026342 Css NA 0.00473 mg/L PBTK NA 50% Rat Human +DTXSID9026342 Css NA 0.02608 mg/L PBTK NA 95% Rat Human +DTXSID9026558 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026558 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026558 Vd NA 0.7654 L/kg 1compartment NA NA Human Human DTXSID9026558 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026558 TK.Half.Life NA 1.689 hours 1compartment NA NA Human Human -DTXSID9026558 Css NA 0.106 mg/L 3compartmentss NA 50% Human Human -DTXSID9026558 Css NA 0.9261 mg/L 3compartmentss NA 95% Human Human -DTXSID9026558 Css NA 0.08758 mg/L PBTK NA 50% Human Human -DTXSID9026558 Css NA 0.6318 mg/L PBTK NA 95% Human Human -DTXSID9026558 Clint NA 7.295 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026558 Fup NA 0.5463 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026558 Vd NA 1.018 L/kg 1compartment NA NA Rat Human +DTXSID9026558 TK.Half.Life NA 1.544 hours 1compartment NA NA Human Human +DTXSID9026558 Css NA 0.1588 mg/L 3compartmentss NA 50% Human Human +DTXSID9026558 Css NA 1.099 mg/L 3compartmentss NA 95% Human Human +DTXSID9026558 Css NA 0.1204 mg/L PBTK NA 50% Human Human +DTXSID9026558 Css NA 0.7288 mg/L PBTK NA 95% Human Human +DTXSID9026558 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026558 Fup 0.404 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026558 Vd NA 0.7195 L/kg 1compartment NA NA Rat Human DTXSID9026558 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026558 TK.Half.Life NA 0.801 hours 1compartment NA NA Rat Human -DTXSID9026558 Css NA 0.05349 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026558 Css NA 0.3701 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026558 Css NA 0.04299 mg/L PBTK NA 50% Rat Human -DTXSID9026558 Css NA 0.238 mg/L PBTK NA 95% Rat Human -DTXSID9026631 Clint NA 7.489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026631 Fup NA 0.4125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026631 Vd NA 1.904 L/kg 1compartment NA NA Human Human +DTXSID9026558 TK.Half.Life NA 0.803 hours 1compartment NA NA Rat Human +DTXSID9026558 Css NA 0.01836 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026558 Css NA 0.09729 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026558 Css NA 0.0139 mg/L PBTK NA 50% Rat Human +DTXSID9026558 Css NA 0.06324 mg/L PBTK NA 95% Rat Human +DTXSID9026631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026631 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026631 Vd NA 1.178 L/kg 1compartment NA NA Human Human DTXSID9026631 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026631 TK.Half.Life NA 4.221 hours 1compartment NA NA Human Human -DTXSID9026631 Css NA 0.1793 mg/L 3compartmentss NA 50% Human Human -DTXSID9026631 Css NA 1.137 mg/L 3compartmentss NA 95% Human Human -DTXSID9026631 Css NA 0.1444 mg/L PBTK NA 50% Human Human -DTXSID9026631 Css NA 0.8129 mg/L PBTK NA 95% Human Human -DTXSID9026631 Clint NA 7.489 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026631 Fup NA 0.4125 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026631 Vd NA 1.529 L/kg 1compartment NA NA Rat Human +DTXSID9026631 TK.Half.Life NA 2.553 hours 1compartment NA NA Human Human +DTXSID9026631 Css NA 0.1997 mg/L 3compartmentss NA 50% Human Human +DTXSID9026631 Css NA 1.641 mg/L 3compartmentss NA 95% Human Human +DTXSID9026631 Css NA 0.1336 mg/L PBTK NA 50% Human Human +DTXSID9026631 Css NA 1.024 mg/L PBTK NA 95% Human Human +DTXSID9026631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026631 Fup 0.137 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026631 Vd NA 0.9295 L/kg 1compartment NA NA Rat Human DTXSID9026631 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026631 TK.Half.Life NA 1.542 hours 1compartment NA NA Rat Human -DTXSID9026631 Css NA 0.09257 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026631 Css NA 0.4296 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026631 Css NA 0.07234 mg/L PBTK NA 50% Rat Human -DTXSID9026631 Css NA 0.2929 mg/L PBTK NA 95% Rat Human -DTXSID9026633 Clint NA 2.023 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026633 Fup NA 0.555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026633 Vd NA 2.834 L/kg 1compartment NA NA Human Human +DTXSID9026631 TK.Half.Life NA 1.072 hours 1compartment NA NA Rat Human +DTXSID9026631 Css NA 0.02578 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026631 Css NA 0.1573 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026631 Css NA 0.01689 mg/L PBTK NA 50% Rat Human +DTXSID9026631 Css NA 0.0953 mg/L PBTK NA 95% Rat Human +DTXSID9026633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026633 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026633 Vd NA 2.203 L/kg 1compartment NA NA Human Human DTXSID9026633 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026633 TK.Half.Life NA 7.889 hours 1compartment NA NA Human Human -DTXSID9026633 Css NA 0.1948 mg/L 3compartmentss NA 50% Human Human -DTXSID9026633 Css NA 1.928 mg/L 3compartmentss NA 95% Human Human -DTXSID9026633 Css NA 0.2369 mg/L PBTK NA 50% Human Human -DTXSID9026633 Css NA 1.475 mg/L PBTK NA 95% Human Human -DTXSID9026633 Clint NA 2.023 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026633 Fup NA 0.555 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026633 Vd NA 2.818 L/kg 1compartment NA NA Rat Human +DTXSID9026633 TK.Half.Life NA 1.944 hours 1compartment NA NA Human Human +DTXSID9026633 Css NA 0.0323 mg/L 3compartmentss NA 50% Human Human +DTXSID9026633 Css NA 0.2993 mg/L 3compartmentss NA 95% Human Human +DTXSID9026633 Css NA 0.03331 mg/L PBTK NA 50% Human Human +DTXSID9026633 Css NA 0.2507 mg/L PBTK NA 95% Human Human +DTXSID9026633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026633 Fup 0.407 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026633 Vd NA 2.18 L/kg 1compartment NA NA Rat Human DTXSID9026633 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026633 TK.Half.Life NA 4.271 hours 1compartment NA NA Rat Human -DTXSID9026633 Css NA 0.08107 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026633 Css NA 0.758 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026633 Css NA 0.09986 mg/L PBTK NA 50% Rat Human -DTXSID9026633 Css NA 0.5218 mg/L PBTK NA 95% Rat Human +DTXSID9026633 TK.Half.Life NA 1.031 hours 1compartment NA NA Rat Human +DTXSID9026633 Css NA 0.003878 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026633 Css NA 0.02866 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026633 Css NA 0.004207 mg/L PBTK NA 50% Rat Human +DTXSID9026633 Css NA 0.02361 mg/L PBTK NA 95% Rat Human DTXSID9026689 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9026689 Fup NA 0.6982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026689 Vd NA 2.28 L/kg 1compartment NA NA Human Human +DTXSID9026689 Fup 0.658 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026689 Vd NA 2.301 L/kg 1compartment NA NA Human Human DTXSID9026689 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9026689 TK.Half.Life NA 21.14 hours 1compartment NA NA Human Human -DTXSID9026689 Css NA 0.8424 mg/L 3compartmentss NA 50% Human Human -DTXSID9026689 Css NA 6.282 mg/L 3compartmentss NA 95% Human Human -DTXSID9026689 Css NA 0.8875 mg/L PBTK NA 50% Human Human -DTXSID9026689 Css NA 4.373 mg/L PBTK NA 95% Human Human +DTXSID9026689 TK.Half.Life NA 22.64 hours 1compartment NA NA Human Human +DTXSID9026689 Css NA 0.4726 mg/L 3compartmentss NA 50% Human Human +DTXSID9026689 Css NA 3.823 mg/L 3compartmentss NA 95% Human Human +DTXSID9026689 Css NA 0.5017 mg/L PBTK NA 50% Human Human +DTXSID9026689 Css NA 2.692 mg/L PBTK NA 95% Human Human DTXSID9026689 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9026689 Fup NA 0.6982 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026689 Vd NA 2.313 L/kg 1compartment NA NA Rat Human +DTXSID9026689 Fup 0.658 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026689 Vd NA 2.333 L/kg 1compartment NA NA Rat Human DTXSID9026689 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026689 TK.Half.Life NA 7.304 hours 1compartment NA NA Rat Human -DTXSID9026689 Css NA 0.2127 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026689 Css NA 1.682 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026689 Css NA 0.2212 mg/L PBTK NA 50% Rat Human -DTXSID9026689 Css NA 1.08 mg/L PBTK NA 95% Rat Human -DTXSID9026710 Clint NA 50.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026710 Fup NA 0.3441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026710 Vd NA 2.309 L/kg 1compartment NA NA Human Human -DTXSID9026710 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026710 TK.Half.Life NA 2.55 hours 1compartment NA NA Human Human -DTXSID9026710 Css NA 0.04714 mg/L 3compartmentss NA 50% Human Human -DTXSID9026710 Css NA 0.325 mg/L 3compartmentss NA 95% Human Human -DTXSID9026710 Css NA 0.03602 mg/L PBTK NA 50% Human Human -DTXSID9026710 Css NA 0.2294 mg/L PBTK NA 95% Human Human -DTXSID9026710 Clint NA 50.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026710 Fup NA 0.3441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026710 Vd NA 1.797 L/kg 1compartment NA NA Rat Human -DTXSID9026710 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026710 TK.Half.Life NA 0.8293 hours 1compartment NA NA Rat Human -DTXSID9026710 Css NA 0.0256 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026710 Css NA 0.1431 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026710 Css NA 0.019 mg/L PBTK NA 50% Rat Human -DTXSID9026710 Css NA 0.09999 mg/L PBTK NA 95% Rat Human -DTXSID9026712 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026712 Fup NA 0.7656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026712 Vd NA 1.374 L/kg 1compartment NA NA Human Human -DTXSID9026712 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9026712 TK.Half.Life NA 12.87 hours 1compartment NA NA Human Human -DTXSID9026712 Css NA 0.9712 mg/L 3compartmentss NA 50% Human Human -DTXSID9026712 Css NA 6.28 mg/L 3compartmentss NA 95% Human Human -DTXSID9026712 Css NA 0.8858 mg/L PBTK NA 50% Human Human -DTXSID9026712 Css NA 4.159 mg/L PBTK NA 95% Human Human -DTXSID9026712 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026712 Fup NA 0.7656 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026712 Vd NA 1.241 L/kg 1compartment NA NA Rat Human +DTXSID9026689 TK.Half.Life NA 7.82 hours 1compartment NA NA Rat Human +DTXSID9026689 Css NA 0.00243 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026689 Css NA 0.02102 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026689 Css NA 0.002536 mg/L PBTK NA 50% Rat Human +DTXSID9026689 Css NA 0.01435 mg/L PBTK NA 95% Rat Human +DTXSID9026712 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026712 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026712 Vd NA 2.073 L/kg 1compartment NA NA Human Human +DTXSID9026712 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9026712 TK.Half.Life NA 2.297 hours 1compartment NA NA Human Human +DTXSID9026712 Css NA 0.05186 mg/L 3compartmentss NA 50% Human Human +DTXSID9026712 Css NA 0.4281 mg/L 3compartmentss NA 95% Human Human +DTXSID9026712 Css NA 0.04298 mg/L PBTK NA 50% Human Human +DTXSID9026712 Css NA 0.3187 mg/L PBTK NA 95% Human Human +DTXSID9026712 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026712 Fup 0.524 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026712 Vd NA 1.672 L/kg 1compartment NA NA Rat Human DTXSID9026712 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026712 TK.Half.Life NA 3.667 hours 1compartment NA NA Rat Human -DTXSID9026712 Css NA 0.2492 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026712 Css NA 1.629 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026712 Css NA 0.221 mg/L PBTK NA 50% Rat Human -DTXSID9026712 Css NA 1.004 mg/L PBTK NA 95% Rat Human -DTXSID9026714 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026714 Fup NA 0.6912 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026714 Vd NA 1.617 L/kg 1compartment NA NA Human Human -DTXSID9026714 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9026714 TK.Half.Life NA 18.47 hours 1compartment NA NA Human Human -DTXSID9026714 Css NA 1.138 mg/L 3compartmentss NA 50% Human Human -DTXSID9026714 Css NA 7.257 mg/L 3compartmentss NA 95% Human Human -DTXSID9026714 Css NA 1.02 mg/L PBTK NA 50% Human Human -DTXSID9026714 Css NA 4.824 mg/L PBTK NA 95% Human Human -DTXSID9026714 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026714 Fup NA 0.6912 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026714 Vd NA 1.396 L/kg 1compartment NA NA Rat Human -DTXSID9026714 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026714 TK.Half.Life NA 4.687 hours 1compartment NA NA Rat Human -DTXSID9026714 Css NA 0.2968 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026714 Css NA 1.828 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026714 Css NA 0.2606 mg/L PBTK NA 50% Rat Human -DTXSID9026714 Css NA 1.13 mg/L PBTK NA 95% Rat Human -DTXSID9026716 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026716 Fup NA 0.9768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026716 Vd NA 0.9805 L/kg 1compartment NA NA Human Human +DTXSID9026712 TK.Half.Life NA 0.8161 hours 1compartment NA NA Rat Human +DTXSID9026712 Css NA 0.006398 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026712 Css NA 0.04191 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026712 Css NA 0.005356 mg/L PBTK NA 50% Rat Human +DTXSID9026712 Css NA 0.03125 mg/L PBTK NA 95% Rat Human +DTXSID9026716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026716 Fup 0.771 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026716 Vd NA 0.749 L/kg 1compartment NA NA Human Human DTXSID9026716 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026716 TK.Half.Life NA 6.564 hours 1compartment NA NA Human Human -DTXSID9026716 Css NA 0.7748 mg/L 3compartmentss NA 50% Human Human -DTXSID9026716 Css NA 5.441 mg/L 3compartmentss NA 95% Human Human -DTXSID9026716 Css NA 0.6908 mg/L PBTK NA 50% Human Human -DTXSID9026716 Css NA 3.553 mg/L PBTK NA 95% Human Human -DTXSID9026716 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026716 Fup NA 0.9768 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026716 Vd NA 0.9841 L/kg 1compartment NA NA Rat Human +DTXSID9026716 TK.Half.Life NA 6.301 hours 1compartment NA NA Human Human +DTXSID9026716 Css NA 0.8608 mg/L 3compartmentss NA 50% Human Human +DTXSID9026716 Css NA 5.381 mg/L 3compartmentss NA 95% Human Human +DTXSID9026716 Css NA 0.7089 mg/L PBTK NA 50% Human Human +DTXSID9026716 Css NA 3.463 mg/L PBTK NA 95% Human Human +DTXSID9026716 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026716 Fup 0.771 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026716 Vd NA 0.7682 L/kg 1compartment NA NA Rat Human DTXSID9026716 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026716 TK.Half.Life NA 2.227 hours 1compartment NA NA Rat Human -DTXSID9026716 Css NA 0.1943 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026716 Css NA 1.509 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026716 Css NA 0.1709 mg/L PBTK NA 50% Rat Human -DTXSID9026716 Css NA 0.9109 mg/L PBTK NA 95% Rat Human -DTXSID9026718 Clint NA 0.004784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026718 Fup NA 0.5366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026718 Vd NA 0.3812 L/kg 1compartment NA NA Human Human +DTXSID9026716 TK.Half.Life NA 2.198 hours 1compartment NA NA Rat Human +DTXSID9026716 Css NA 0.01591 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026716 Css NA 0.1372 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026716 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID9026716 Css NA 0.08652 mg/L PBTK NA 95% Rat Human +DTXSID9026718 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026718 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026718 Vd NA 0.6907 L/kg 1compartment NA NA Human Human DTXSID9026718 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026718 TK.Half.Life NA 4.56 hours 1compartment NA NA Human Human -DTXSID9026718 Css NA 1.481 mg/L 3compartmentss NA 50% Human Human -DTXSID9026718 Css NA 8.04 mg/L 3compartmentss NA 95% Human Human -DTXSID9026718 Css NA 1.04 mg/L PBTK NA 50% Human Human -DTXSID9026718 Css NA 4.907 mg/L PBTK NA 95% Human Human -DTXSID9026718 Clint NA 0.004784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026718 Fup NA 0.5366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026718 Vd NA 0.3948 L/kg 1compartment NA NA Rat Human +DTXSID9026718 TK.Half.Life NA 7.173 hours 1compartment NA NA Human Human +DTXSID9026718 Css NA 1.016 mg/L 3compartmentss NA 50% Human Human +DTXSID9026718 Css NA 6.74 mg/L 3compartmentss NA 95% Human Human +DTXSID9026718 Css NA 0.8134 mg/L PBTK NA 50% Human Human +DTXSID9026718 Css NA 4.234 mg/L PBTK NA 95% Human Human +DTXSID9026718 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026718 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026718 Vd NA 0.7023 L/kg 1compartment NA NA Rat Human DTXSID9026718 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026718 TK.Half.Life NA 1.615 hours 1compartment NA NA Rat Human -DTXSID9026718 Css NA 0.4054 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026718 Css NA 2.059 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026718 Css NA 0.2704 mg/L PBTK NA 50% Rat Human -DTXSID9026718 Css NA 1.172 mg/L PBTK NA 95% Rat Human -DTXSID9026841 Clint NA 26.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026841 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026841 Vd NA 3.123 L/kg 1compartment NA NA Human Human -DTXSID9026841 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID9026841 TK.Half.Life NA 76.85 hours 1compartment NA NA Human Human -DTXSID9026841 Css NA 2.869 mg/L 3compartmentss NA 50% Human Human -DTXSID9026841 Css NA 16.26 mg/L 3compartmentss NA 95% Human Human -DTXSID9026841 Css NA 1.976 mg/L PBTK NA 50% Human Human -DTXSID9026841 Css NA 11.24 mg/L PBTK NA 95% Human Human -DTXSID9026841 Clint NA 26.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026841 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026841 Vd NA 2.34 L/kg 1compartment NA NA Rat Human -DTXSID9026841 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID9026841 TK.Half.Life NA 10.37 hours 1compartment NA NA Rat Human -DTXSID9026841 Css NA 1.638 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026841 Css NA 6.902 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026841 Css NA 1.086 mg/L PBTK NA 50% Rat Human -DTXSID9026841 Css NA 4.547 mg/L PBTK NA 95% Rat Human -DTXSID9026849 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026849 Fup NA 0.9538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026849 Vd NA 0.7862 L/kg 1compartment NA NA Human Human +DTXSID9026718 TK.Half.Life NA 2.48 hours 1compartment NA NA Rat Human +DTXSID9026718 Css NA 0.01962 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026718 Css NA 0.1633 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026718 Css NA 0.01525 mg/L PBTK NA 50% Rat Human +DTXSID9026718 Css NA 0.1024 mg/L PBTK NA 95% Rat Human +DTXSID9026841 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026841 Fup 0.0127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026841 Vd NA 4.248 L/kg 1compartment NA NA Human Human +DTXSID9026841 Days.Css NA 22 Days PBTK NA NA Human Human +DTXSID9026841 TK.Half.Life NA 128.3 hours 1compartment NA NA Human Human +DTXSID9026841 Css NA 1.714 mg/L 3compartmentss NA 50% Human Human +DTXSID9026841 Css NA 10.95 mg/L 3compartmentss NA 95% Human Human +DTXSID9026841 Css NA 1.308 mg/L PBTK NA 50% Human Human +DTXSID9026841 Css NA 8.188 mg/L PBTK NA 95% Human Human +DTXSID9026841 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026841 Fup 0.0127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026841 Vd NA 3.222 L/kg 1compartment NA NA Rat Human +DTXSID9026841 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID9026841 TK.Half.Life NA 17.46 hours 1compartment NA NA Rat Human +DTXSID9026841 Css NA 0.01867 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026841 Css NA 0.112 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026841 Css NA 0.01382 mg/L PBTK NA 50% Rat Human +DTXSID9026841 Css NA 0.08148 mg/L PBTK NA 95% Rat Human +DTXSID9026849 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026849 Fup 0.827 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026849 Vd NA 0.7212 L/kg 1compartment NA NA Human Human DTXSID9026849 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026849 TK.Half.Life NA 5.336 hours 1compartment NA NA Human Human -DTXSID9026849 Css NA 0.8953 mg/L 3compartmentss NA 50% Human Human -DTXSID9026849 Css NA 4.909 mg/L 3compartmentss NA 95% Human Human -DTXSID9026849 Css NA 0.7484 mg/L PBTK NA 50% Human Human -DTXSID9026849 Css NA 3.253 mg/L PBTK NA 95% Human Human -DTXSID9026849 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026849 Fup NA 0.9538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026849 Vd NA 0.8183 L/kg 1compartment NA NA Rat Human +DTXSID9026849 TK.Half.Life NA 5.645 hours 1compartment NA NA Human Human +DTXSID9026849 Css NA 0.8378 mg/L 3compartmentss NA 50% Human Human +DTXSID9026849 Css NA 5.009 mg/L 3compartmentss NA 95% Human Human +DTXSID9026849 Css NA 0.6848 mg/L PBTK NA 50% Human Human +DTXSID9026849 Css NA 3.212 mg/L PBTK NA 95% Human Human +DTXSID9026849 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026849 Fup 0.827 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026849 Vd NA 0.7503 L/kg 1compartment NA NA Rat Human DTXSID9026849 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026849 TK.Half.Life NA 1.892 hours 1compartment NA NA Rat Human -DTXSID9026849 Css NA 0.2256 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026849 Css NA 1.218 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026849 Css NA 0.1841 mg/L PBTK NA 50% Rat Human -DTXSID9026849 Css NA 0.7413 mg/L PBTK NA 95% Rat Human +DTXSID9026849 TK.Half.Life NA 2.001 hours 1compartment NA NA Rat Human +DTXSID9026849 Css NA 0.01568 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026849 Css NA 0.1212 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026849 Css NA 0.01238 mg/L PBTK NA 50% Rat Human +DTXSID9026849 Css NA 0.07817 mg/L PBTK NA 95% Rat Human DTXSID9026899 Clint NA 1.793 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9026899 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026899 Vd NA 1.156 L/kg 1compartment NA NA Human Human +DTXSID9026899 Vd NA 1.088 L/kg 1compartment NA NA Human Human DTXSID9026899 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026899 TK.Half.Life NA 2.269 hours 1compartment NA NA Human Human -DTXSID9026899 Css NA 0.1998 mg/L 3compartmentss NA 50% Human Human -DTXSID9026899 Css NA 1.542 mg/L 3compartmentss NA 95% Human Human -DTXSID9026899 Css NA 0.1804 mg/L PBTK NA 50% Human Human -DTXSID9026899 Css NA 1.072 mg/L PBTK NA 95% Human Human +DTXSID9026899 TK.Half.Life NA 2.126 hours 1compartment NA NA Human Human +DTXSID9026899 Css NA 0.1946 mg/L 3compartmentss NA 50% Human Human +DTXSID9026899 Css NA 1.367 mg/L 3compartmentss NA 95% Human Human +DTXSID9026899 Css NA 0.1731 mg/L PBTK NA 50% Human Human +DTXSID9026899 Css NA 0.9594 mg/L PBTK NA 95% Human Human DTXSID9026899 Clint NA 1.793 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9026899 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026899 Vd NA 1.126 L/kg 1compartment NA NA Rat Human +DTXSID9026899 Vd NA 1.073 L/kg 1compartment NA NA Rat Human DTXSID9026899 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026899 TK.Half.Life NA 1.11 hours 1compartment NA NA Rat Human -DTXSID9026899 Css NA 0.08082 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026899 Css NA 0.5475 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026899 Css NA 0.07331 mg/L PBTK NA 50% Rat Human -DTXSID9026899 Css NA 0.3463 mg/L PBTK NA 95% Rat Human -DTXSID9026922 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026922 Fup NA 0.9147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026922 Vd NA 0.9856 L/kg 1compartment NA NA Human Human +DTXSID9026899 TK.Half.Life NA 1.058 hours 1compartment NA NA Rat Human +DTXSID9026899 Css NA 0.01813 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026899 Css NA 0.1258 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026899 Css NA 0.01688 mg/L PBTK NA 50% Rat Human +DTXSID9026899 Css NA 0.0809 mg/L PBTK NA 95% Rat Human +DTXSID9026922 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026922 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026922 Vd NA 0.7395 L/kg 1compartment NA NA Human Human DTXSID9026922 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026922 TK.Half.Life NA 6.978 hours 1compartment NA NA Human Human -DTXSID9026922 Css NA 0.8524 mg/L 3compartmentss NA 50% Human Human -DTXSID9026922 Css NA 3.173 mg/L 3compartmentss NA 95% Human Human -DTXSID9026922 Css NA 0.7382 mg/L PBTK NA 50% Human Human -DTXSID9026922 Css NA 2.266 mg/L PBTK NA 95% Human Human -DTXSID9026922 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026922 Fup NA 0.9147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026922 Vd NA 1.013 L/kg 1compartment NA NA Rat Human +DTXSID9026922 TK.Half.Life NA 6.975 hours 1compartment NA NA Human Human +DTXSID9026922 Css NA 1.072 mg/L 3compartmentss NA 50% Human Human +DTXSID9026922 Css NA 6.894 mg/L 3compartmentss NA 95% Human Human +DTXSID9026922 Css NA 0.8648 mg/L PBTK NA 50% Human Human +DTXSID9026922 Css NA 4.406 mg/L PBTK NA 95% Human Human +DTXSID9026922 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026922 Fup 0.686 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026922 Vd NA 0.7688 L/kg 1compartment NA NA Rat Human DTXSID9026922 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026922 TK.Half.Life NA 2.442 hours 1compartment NA NA Rat Human -DTXSID9026922 Css NA 0.219 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026922 Css NA 0.7793 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026922 Css NA 0.185 mg/L PBTK NA 50% Rat Human -DTXSID9026922 Css NA 0.5074 mg/L PBTK NA 95% Rat Human -DTXSID9026924 Clint NA 67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026924 Fup NA 0.0311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026924 Vd NA 3.24 L/kg 1compartment NA NA Human Human -DTXSID9026924 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9026924 TK.Half.Life NA 2.862 hours 1compartment NA NA Human Human -DTXSID9026924 Css NA 0.02454 mg/L 3compartmentss NA 50% Human Human -DTXSID9026924 Css NA 0.1965 mg/L 3compartmentss NA 95% Human Human -DTXSID9026924 Css NA 0.01907 mg/L PBTK NA 50% Human Human -DTXSID9026924 Css NA 0.1406 mg/L PBTK NA 95% Human Human -DTXSID9026924 Clint NA 67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026924 Fup NA 0.0311 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026924 Vd NA 2.691 L/kg 1compartment NA NA Rat Human -DTXSID9026924 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9026924 TK.Half.Life NA 0.9911 hours 1compartment NA NA Rat Human -DTXSID9026924 Css NA 0.0134 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026924 Css NA 0.09134 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026924 Css NA 0.01018 mg/L PBTK NA 50% Rat Human -DTXSID9026924 Css NA 0.06455 mg/L PBTK NA 95% Rat Human -DTXSID9026926 Clint NA 39.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026926 Fup NA 0.0243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026926 Vd NA 4.196 L/kg 1compartment NA NA Human Human -DTXSID9026926 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID9026926 TK.Half.Life NA 70.28 hours 1compartment NA NA Human Human -DTXSID9026926 Css NA 1.738 mg/L 3compartmentss NA 50% Human Human -DTXSID9026926 Css NA 9.767 mg/L 3compartmentss NA 95% Human Human -DTXSID9026926 Css NA 1.324 mg/L PBTK NA 50% Human Human -DTXSID9026926 Css NA 7.332 mg/L PBTK NA 95% Human Human -DTXSID9026926 Clint NA 39.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026926 Fup NA 0.0243 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026926 Vd NA 3.18 L/kg 1compartment NA NA Rat Human -DTXSID9026926 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID9026926 TK.Half.Life NA 9.705 hours 1compartment NA NA Rat Human -DTXSID9026926 Css NA 0.975 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026926 Css NA 4.133 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026926 Css NA 0.7141 mg/L PBTK NA 50% Rat Human -DTXSID9026926 Css NA 2.986 mg/L PBTK NA 95% Rat Human -DTXSID9026974 Clint NA 60 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026974 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9026974 Vd NA 3.062 L/kg 1compartment NA NA Human Human -DTXSID9026974 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9026974 TK.Half.Life NA 28.18 hours 1compartment NA NA Human Human -DTXSID9026974 Css NA 1.076 mg/L 3compartmentss NA 50% Human Human -DTXSID9026974 Css NA 7.082 mg/L 3compartmentss NA 95% Human Human -DTXSID9026974 Css NA 0.7461 mg/L PBTK NA 50% Human Human -DTXSID9026974 Css NA 4.774 mg/L PBTK NA 95% Human Human -DTXSID9026974 Clint NA 60 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026974 Fup NA 0.0183 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9026974 Vd NA 2.293 L/kg 1compartment NA NA Rat Human -DTXSID9026974 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9026974 TK.Half.Life NA 4.426 hours 1compartment NA NA Rat Human -DTXSID9026974 Css NA 0.6013 mg/L 3compartmentss NA 50% Rat Human -DTXSID9026974 Css NA 3.153 mg/L 3compartmentss NA 95% Rat Human -DTXSID9026974 Css NA 0.3981 mg/L PBTK NA 50% Rat Human -DTXSID9026974 Css NA 1.998 mg/L PBTK NA 95% Rat Human -DTXSID9027021 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027021 Fup NA 0.3935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027021 Vd NA 0.7983 L/kg 1compartment NA NA Human Human -DTXSID9027021 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9027021 TK.Half.Life NA 13.52 hours 1compartment NA NA Human Human -DTXSID9027021 Css NA 1.822 mg/L 3compartmentss NA 50% Human Human -DTXSID9027021 Css NA 8.029 mg/L 3compartmentss NA 95% Human Human -DTXSID9027021 Css NA 1.397 mg/L PBTK NA 50% Human Human -DTXSID9027021 Css NA 5.238 mg/L PBTK NA 95% Human Human -DTXSID9027021 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027021 Fup NA 0.3935 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027021 Vd NA 0.7407 L/kg 1compartment NA NA Rat Human +DTXSID9026922 TK.Half.Life NA 2.47 hours 1compartment NA NA Rat Human +DTXSID9026922 Css NA 0.06432 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026922 Css NA 0.4055 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026922 Css NA 0.05182 mg/L PBTK NA 50% Rat Human +DTXSID9026922 Css NA 0.2479 mg/L PBTK NA 95% Rat Human +DTXSID9026974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026974 Fup 0.0245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9026974 Vd NA 3.126 L/kg 1compartment NA NA Human Human +DTXSID9026974 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID9026974 TK.Half.Life NA 94.2 hours 1compartment NA NA Human Human +DTXSID9026974 Css NA 3.388 mg/L 3compartmentss NA 50% Human Human +DTXSID9026974 Css NA 19.97 mg/L 3compartmentss NA 95% Human Human +DTXSID9026974 Css NA 2.358 mg/L PBTK NA 50% Human Human +DTXSID9026974 Css NA 13.88 mg/L PBTK NA 95% Human Human +DTXSID9026974 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026974 Fup 0.0245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9026974 Vd NA 2.342 L/kg 1compartment NA NA Rat Human +DTXSID9026974 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID9026974 TK.Half.Life NA 12.52 hours 1compartment NA NA Rat Human +DTXSID9026974 Css NA 0.4465 mg/L 3compartmentss NA 50% Rat Human +DTXSID9026974 Css NA 2.163 mg/L 3compartmentss NA 95% Rat Human +DTXSID9026974 Css NA 0.3064 mg/L PBTK NA 50% Rat Human +DTXSID9026974 Css NA 1.508 mg/L PBTK NA 95% Rat Human +DTXSID9027021 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027021 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027021 Vd NA 1.313 L/kg 1compartment NA NA Human Human +DTXSID9027021 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9027021 TK.Half.Life NA 1.204 hours 1compartment NA NA Human Human +DTXSID9027021 Css NA 0.03442 mg/L 3compartmentss NA 50% Human Human +DTXSID9027021 Css NA 0.3809 mg/L 3compartmentss NA 95% Human Human +DTXSID9027021 Css NA 0.02901 mg/L PBTK NA 50% Human Human +DTXSID9027021 Css NA 0.2628 mg/L PBTK NA 95% Human Human +DTXSID9027021 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027021 Fup 0.573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027021 Vd NA 1.154 L/kg 1compartment NA NA Rat Human DTXSID9027021 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027021 TK.Half.Life NA 4.181 hours 1compartment NA NA Rat Human -DTXSID9027021 Css NA 0.5034 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027021 Css NA 1.831 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027021 Css NA 0.3681 mg/L PBTK NA 50% Rat Human -DTXSID9027021 Css NA 1.105 mg/L PBTK NA 95% Rat Human -DTXSID9027104 Clint NA 34.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027104 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027104 Vd NA 111 L/kg 1compartment NA NA Human Human -DTXSID9027104 Days.Css NA 531 Days PBTK NA NA Human Human -DTXSID9027104 TK.Half.Life NA 2072 hours 1compartment NA NA Human Human -DTXSID9027104 Css NA 0.1145 mg/L 3compartmentss NA 50% Human Human -DTXSID9027104 Css NA 0.6957 mg/L 3compartmentss NA 95% Human Human -DTXSID9027104 Css NA 1.553 mg/L PBTK NA 50% Human Human -DTXSID9027104 Css NA 8.446 mg/L PBTK NA 95% Human Human -DTXSID9027104 Clint NA 34.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027104 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027104 Vd NA 96.26 L/kg 1compartment NA NA Rat Human -DTXSID9027104 Days.Css NA 336 Days PBTK NA NA Rat Human -DTXSID9027104 TK.Half.Life NA 317.1 hours 1compartment NA NA Rat Human -DTXSID9027104 Css NA 0.05792 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027104 Css NA 0.2573 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027104 Css NA 0.8378 mg/L PBTK NA 50% Rat Human -DTXSID9027104 Css NA 3.545 mg/L PBTK NA 95% Rat Human -DTXSID9027158 Clint NA 11.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027158 Fup NA 0.1941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027158 Vd NA 0.82 L/kg 1compartment NA NA Human Human +DTXSID9027021 TK.Half.Life NA 0.515 hours 1compartment NA NA Rat Human +DTXSID9027021 Css NA 0.004196 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027021 Css NA 0.03839 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027021 Css NA 0.003604 mg/L PBTK NA 50% Rat Human +DTXSID9027021 Css NA 0.02632 mg/L PBTK NA 95% Rat Human +DTXSID9027025 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027025 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027025 Vd NA 9.531 L/kg 1compartment NA NA Human Human +DTXSID9027025 Days.Css NA 58 Days PBTK NA NA Human Human +DTXSID9027025 TK.Half.Life NA 285.1 hours 1compartment NA NA Human Human +DTXSID9027025 Css NA 1.127 mg/L 3compartmentss NA 50% Human Human +DTXSID9027025 Css NA 7.357 mg/L 3compartmentss NA 95% Human Human +DTXSID9027025 Css NA 1.306 mg/L PBTK NA 50% Human Human +DTXSID9027025 Css NA 8.229 mg/L PBTK NA 95% Human Human +DTXSID9027025 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027025 Fup 0.014 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027025 Vd NA 7.488 L/kg 1compartment NA NA Rat Human +DTXSID9027025 Days.Css NA 35 Days PBTK NA NA Rat Human +DTXSID9027025 TK.Half.Life NA 39.56 hours 1compartment NA NA Rat Human +DTXSID9027025 Css NA 0.01185 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027025 Css NA 0.07279 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027025 Css NA 0.01375 mg/L PBTK NA 50% Rat Human +DTXSID9027025 Css NA 0.08328 mg/L PBTK NA 95% Rat Human +DTXSID9027158 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027158 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027158 Vd NA 0.8136 L/kg 1compartment NA NA Human Human DTXSID9027158 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027158 TK.Half.Life NA 1.992 hours 1compartment NA NA Human Human -DTXSID9027158 Css NA 0.2116 mg/L 3compartmentss NA 50% Human Human -DTXSID9027158 Css NA 1.38 mg/L 3compartmentss NA 95% Human Human -DTXSID9027158 Css NA 0.146 mg/L PBTK NA 50% Human Human -DTXSID9027158 Css NA 0.9051 mg/L PBTK NA 95% Human Human -DTXSID9027158 Clint NA 11.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027158 Fup NA 0.1941 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027158 Vd NA 0.6968 L/kg 1compartment NA NA Rat Human +DTXSID9027158 TK.Half.Life NA 1.369 hours 1compartment NA NA Human Human +DTXSID9027158 Css NA 0.11 mg/L 3compartmentss NA 50% Human Human +DTXSID9027158 Css NA 0.7818 mg/L 3compartmentss NA 95% Human Human +DTXSID9027158 Css NA 0.07617 mg/L PBTK NA 50% Human Human +DTXSID9027158 Css NA 0.5127 mg/L PBTK NA 95% Human Human +DTXSID9027158 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027158 Fup 0.194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027158 Vd NA 0.6922 L/kg 1compartment NA NA Rat Human DTXSID9027158 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027158 TK.Half.Life NA 0.9558 hours 1compartment NA NA Rat Human -DTXSID9027158 Css NA 0.1145 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027158 Css NA 0.5342 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027158 Css NA 0.07544 mg/L PBTK NA 50% Rat Human -DTXSID9027158 Css NA 0.3299 mg/L PBTK NA 95% Rat Human +DTXSID9027158 TK.Half.Life NA 0.6336 hours 1compartment NA NA Rat Human +DTXSID9027158 Css NA 0.01407 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027158 Css NA 0.07263 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027158 Css NA 0.009568 mg/L PBTK NA 50% Rat Human +DTXSID9027158 Css NA 0.0472 mg/L PBTK NA 95% Rat Human DTXSID9027233 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9027233 Fup NA 0.4967 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9027233 Vd NA 0.6538 L/kg 1compartment NA NA Human Human DTXSID9027233 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9027233 TK.Half.Life NA 8.515 hours 1compartment NA NA Human Human -DTXSID9027233 Css NA 1.386 mg/L 3compartmentss NA 50% Human Human -DTXSID9027233 Css NA 7.396 mg/L 3compartmentss NA 95% Human Human -DTXSID9027233 Css NA 1.106 mg/L PBTK NA 50% Human Human -DTXSID9027233 Css NA 4.8 mg/L PBTK NA 95% Human Human +DTXSID9027233 Css NA 1.164 mg/L 3compartmentss NA 50% Human Human +DTXSID9027233 Css NA 6.228 mg/L 3compartmentss NA 95% Human Human +DTXSID9027233 Css NA 0.9322 mg/L PBTK NA 50% Human Human +DTXSID9027233 Css NA 4.055 mg/L PBTK NA 95% Human Human DTXSID9027233 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9027233 Fup NA 0.4967 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9027233 Vd NA 0.6644 L/kg 1compartment NA NA Rat Human DTXSID9027233 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9027233 TK.Half.Life NA 2.948 hours 1compartment NA NA Rat Human -DTXSID9027233 Css NA 0.3741 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027233 Css NA 1.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027233 Css NA 0.2867 mg/L PBTK NA 50% Rat Human -DTXSID9027233 Css NA 1.064 mg/L PBTK NA 95% Rat Human -DTXSID9027239 Clint NA 0.1171 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027239 Fup NA 0.1116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027239 Vd NA 0.2803 L/kg 1compartment NA NA Human Human +DTXSID9027233 Css NA 0.022 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027233 Css NA 0.1637 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027233 Css NA 0.01705 mg/L PBTK NA 50% Rat Human +DTXSID9027233 Css NA 0.1061 mg/L PBTK NA 95% Rat Human +DTXSID9027239 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027239 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027239 Vd NA 0.2965 L/kg 1compartment NA NA Human Human DTXSID9027239 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9027239 TK.Half.Life NA 13.62 hours 1compartment NA NA Human Human -DTXSID9027239 Css NA 7.327 mg/L 3compartmentss NA 50% Human Human -DTXSID9027239 Css NA 34.94 mg/L 3compartmentss NA 95% Human Human -DTXSID9027239 Css NA 4.544 mg/L PBTK NA 50% Human Human -DTXSID9027239 Css NA 20.59 mg/L PBTK NA 95% Human Human -DTXSID9027239 Clint NA 0.1171 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027239 Fup NA 0.1116 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027239 Vd NA 0.2766 L/kg 1compartment NA NA Rat Human +DTXSID9027239 TK.Half.Life NA 14.87 hours 1compartment NA NA Human Human +DTXSID9027239 Css NA 7.312 mg/L 3compartmentss NA 50% Human Human +DTXSID9027239 Css NA 33.29 mg/L 3compartmentss NA 95% Human Human +DTXSID9027239 Css NA 4.586 mg/L PBTK NA 50% Human Human +DTXSID9027239 Css NA 19.72 mg/L PBTK NA 95% Human Human +DTXSID9027239 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027239 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027239 Vd NA 0.2928 L/kg 1compartment NA NA Rat Human DTXSID9027239 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027239 TK.Half.Life NA 4.994 hours 1compartment NA NA Rat Human -DTXSID9027239 Css NA 2.319 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027239 Css NA 9.214 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027239 Css NA 1.346 mg/L PBTK NA 50% Rat Human -DTXSID9027239 Css NA 5.077 mg/L PBTK NA 95% Rat Human -DTXSID9027281 Clint NA 0.4806 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027281 Fup NA 0.0826 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027281 Vd NA 0.2915 L/kg 1compartment NA NA Human Human -DTXSID9027281 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9027281 TK.Half.Life NA 12.68 hours 1compartment NA NA Human Human -DTXSID9027281 Css NA 6.896 mg/L 3compartmentss NA 50% Human Human -DTXSID9027281 Css NA 34.29 mg/L 3compartmentss NA 95% Human Human -DTXSID9027281 Css NA 4.246 mg/L PBTK NA 50% Human Human -DTXSID9027281 Css NA 19.88 mg/L PBTK NA 95% Human Human -DTXSID9027281 Clint NA 0.4806 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027281 Fup NA 0.0826 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027281 Vd NA 0.2911 L/kg 1compartment NA NA Rat Human +DTXSID9027239 TK.Half.Life NA 5.005 hours 1compartment NA NA Rat Human +DTXSID9027239 Css NA 0.476 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027239 Css NA 1.829 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027239 Css NA 0.29 mg/L PBTK NA 50% Rat Human +DTXSID9027239 Css NA 1.048 mg/L PBTK NA 95% Rat Human +DTXSID9027281 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027281 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027281 Vd NA 0.35 L/kg 1compartment NA NA Human Human +DTXSID9027281 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9027281 TK.Half.Life NA 1.794 hours 1compartment NA NA Human Human +DTXSID9027281 Css NA 0.3692 mg/L 3compartmentss NA 50% Human Human +DTXSID9027281 Css NA 2.841 mg/L 3compartmentss NA 95% Human Human +DTXSID9027281 Css NA 0.2362 mg/L PBTK NA 50% Human Human +DTXSID9027281 Css NA 1.706 mg/L PBTK NA 95% Human Human +DTXSID9027281 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027281 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027281 Vd NA 0.3506 L/kg 1compartment NA NA Rat Human DTXSID9027281 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027281 TK.Half.Life NA 5.594 hours 1compartment NA NA Rat Human -DTXSID9027281 Css NA 2.562 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027281 Css NA 10.48 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027281 Css NA 1.475 mg/L PBTK NA 50% Rat Human -DTXSID9027281 Css NA 5.779 mg/L PBTK NA 95% Rat Human -DTXSID9027312 Clint NA 31.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027312 Fup NA 0.3762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027312 Vd NA 1.137 L/kg 1compartment NA NA Human Human +DTXSID9027281 TK.Half.Life NA 1.085 hours 1compartment NA NA Rat Human +DTXSID9027281 Css NA 0.003731 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027281 Css NA 0.02317 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027281 Css NA 0.002226 mg/L PBTK NA 50% Rat Human +DTXSID9027281 Css NA 0.01317 mg/L PBTK NA 95% Rat Human +DTXSID9027312 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027312 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027312 Vd NA 1.118 L/kg 1compartment NA NA Human Human DTXSID9027312 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027312 TK.Half.Life NA 1.15 hours 1compartment NA NA Human Human -DTXSID9027312 Css NA 0.03934 mg/L 3compartmentss NA 50% Human Human -DTXSID9027312 Css NA 0.2916 mg/L 3compartmentss NA 95% Human Human -DTXSID9027312 Css NA 0.03049 mg/L PBTK NA 50% Human Human -DTXSID9027312 Css NA 0.2042 mg/L PBTK NA 95% Human Human -DTXSID9027312 Clint NA 31.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027312 Fup NA 0.3762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027312 Vd NA 0.9784 L/kg 1compartment NA NA Rat Human +DTXSID9027312 TK.Half.Life NA 1.315 hours 1compartment NA NA Human Human +DTXSID9027312 Css NA 0.05549 mg/L 3compartmentss NA 50% Human Human +DTXSID9027312 Css NA 0.4241 mg/L 3compartmentss NA 95% Human Human +DTXSID9027312 Css NA 0.04254 mg/L PBTK NA 50% Human Human +DTXSID9027312 Css NA 0.2964 mg/L PBTK NA 95% Human Human +DTXSID9027312 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027312 Fup 0.365 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027312 Vd NA 0.9617 L/kg 1compartment NA NA Rat Human DTXSID9027312 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027312 TK.Half.Life NA 0.4857 hours 1compartment NA NA Rat Human -DTXSID9027312 Css NA 0.02119 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027312 Css NA 0.1271 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027312 Css NA 0.01579 mg/L PBTK NA 50% Rat Human -DTXSID9027312 Css NA 0.0843 mg/L PBTK NA 95% Rat Human -DTXSID9027314 Clint NA 0.01645 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027314 Fup NA 0.5194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027314 Vd NA 0.6425 L/kg 1compartment NA NA Human Human +DTXSID9027312 TK.Half.Life NA 0.5733 hours 1compartment NA NA Rat Human +DTXSID9027312 Css NA 0.00678 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027312 Css NA 0.03911 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027312 Css NA 0.005244 mg/L PBTK NA 50% Rat Human +DTXSID9027312 Css NA 0.02749 mg/L PBTK NA 95% Rat Human +DTXSID9027314 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027314 Fup 0.801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027314 Vd NA 0.8487 L/kg 1compartment NA NA Human Human DTXSID9027314 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027314 TK.Half.Life NA 7.787 hours 1compartment NA NA Human Human -DTXSID9027314 Css NA 1.295 mg/L 3compartmentss NA 50% Human Human -DTXSID9027314 Css NA 7.099 mg/L 3compartmentss NA 95% Human Human -DTXSID9027314 Css NA 1.039 mg/L PBTK NA 50% Human Human -DTXSID9027314 Css NA 4.554 mg/L PBTK NA 95% Human Human -DTXSID9027314 Clint NA 0.01645 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027314 Fup NA 0.5194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027314 Vd NA 0.6528 L/kg 1compartment NA NA Rat Human +DTXSID9027314 TK.Half.Life NA 6.856 hours 1compartment NA NA Human Human +DTXSID9027314 Css NA 0.7929 mg/L 3compartmentss NA 50% Human Human +DTXSID9027314 Css NA 5.072 mg/L 3compartmentss NA 95% Human Human +DTXSID9027314 Css NA 0.6944 mg/L PBTK NA 50% Human Human +DTXSID9027314 Css NA 3.383 mg/L PBTK NA 95% Human Human +DTXSID9027314 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027314 Fup 0.801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027314 Vd NA 0.8634 L/kg 1compartment NA NA Rat Human DTXSID9027314 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027314 TK.Half.Life NA 2.734 hours 1compartment NA NA Rat Human -DTXSID9027314 Css NA 0.3605 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027314 Css NA 1.866 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027314 Css NA 0.2757 mg/L PBTK NA 50% Rat Human -DTXSID9027314 Css NA 1.112 mg/L PBTK NA 95% Rat Human +DTXSID9027314 TK.Half.Life NA 2.377 hours 1compartment NA NA Rat Human +DTXSID9027314 Css NA 0.01473 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027314 Css NA 0.1224 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027314 Css NA 0.0125 mg/L PBTK NA 50% Rat Human +DTXSID9027314 Css NA 0.08181 mg/L PBTK NA 95% Rat Human DTXSID9027360 Clint NA 4.752e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9027360 Fup NA 0.414 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027360 Vd NA 0.3214 L/kg 1compartment NA NA Human Human +DTXSID9027360 Vd NA 0.3357 L/kg 1compartment NA NA Human Human DTXSID9027360 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027360 TK.Half.Life NA 5.023 hours 1compartment NA NA Human Human -DTXSID9027360 Css NA 1.945 mg/L 3compartmentss NA 50% Human Human -DTXSID9027360 Css NA 8.057 mg/L 3compartmentss NA 95% Human Human -DTXSID9027360 Css NA 1.304 mg/L PBTK NA 50% Human Human -DTXSID9027360 Css NA 4.862 mg/L PBTK NA 95% Human Human +DTXSID9027360 TK.Half.Life NA 5.247 hours 1compartment NA NA Human Human +DTXSID9027360 Css NA 1.619 mg/L 3compartmentss NA 50% Human Human +DTXSID9027360 Css NA 7.038 mg/L 3compartmentss NA 95% Human Human +DTXSID9027360 Css NA 1.099 mg/L PBTK NA 50% Human Human +DTXSID9027360 Css NA 4.294 mg/L PBTK NA 95% Human Human DTXSID9027360 Clint NA 4.752e-05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9027360 Fup NA 0.414 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027360 Vd NA 0.3347 L/kg 1compartment NA NA Rat Human +DTXSID9027360 Vd NA 0.3471 L/kg 1compartment NA NA Rat Human DTXSID9027360 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027360 TK.Half.Life NA 1.782 hours 1compartment NA NA Rat Human -DTXSID9027360 Css NA 0.5322 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027360 Css NA 2.004 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027360 Css NA 0.3382 mg/L PBTK NA 50% Rat Human -DTXSID9027360 Css NA 1.139 mg/L PBTK NA 95% Rat Human -DTXSID9027368 Clint NA 9.374 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027368 Fup NA 0.2308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027368 Vd NA 0.3255 L/kg 1compartment NA NA Human Human +DTXSID9027360 TK.Half.Life NA 1.848 hours 1compartment NA NA Rat Human +DTXSID9027360 Css NA 0.0299 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027360 Css NA 0.1849 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027360 Css NA 0.01959 mg/L PBTK NA 50% Rat Human +DTXSID9027360 Css NA 0.1124 mg/L PBTK NA 95% Rat Human +DTXSID9027364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027364 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027364 Vd NA 2.236 L/kg 1compartment NA NA Human Human +DTXSID9027364 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9027364 TK.Half.Life NA 3.44 hours 1compartment NA NA Human Human +DTXSID9027364 Css NA 0.09465 mg/L 3compartmentss NA 50% Human Human +DTXSID9027364 Css NA 0.633 mg/L 3compartmentss NA 95% Human Human +DTXSID9027364 Css NA 0.07339 mg/L PBTK NA 50% Human Human +DTXSID9027364 Css NA 0.4552 mg/L PBTK NA 95% Human Human +DTXSID9027364 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027364 Fup 0.35 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027364 Vd NA 1.75 L/kg 1compartment NA NA Rat Human +DTXSID9027364 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9027364 TK.Half.Life NA 1.127 hours 1compartment NA NA Rat Human +DTXSID9027364 Css NA 0.01181 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027364 Css NA 0.06142 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027364 Css NA 0.00919 mg/L PBTK NA 50% Rat Human +DTXSID9027364 Css NA 0.04409 mg/L PBTK NA 95% Rat Human +DTXSID9027368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027368 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027368 Vd NA 0.4186 L/kg 1compartment NA NA Human Human DTXSID9027368 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027368 TK.Half.Life NA 0.7903 hours 1compartment NA NA Human Human -DTXSID9027368 Css NA 0.2255 mg/L 3compartmentss NA 50% Human Human -DTXSID9027368 Css NA 1.371 mg/L 3compartmentss NA 95% Human Human -DTXSID9027368 Css NA 0.1464 mg/L PBTK NA 50% Human Human -DTXSID9027368 Css NA 0.8551 mg/L PBTK NA 95% Human Human -DTXSID9027368 Clint NA 9.374 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027368 Fup NA 0.2308 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027368 Vd NA 0.3281 L/kg 1compartment NA NA Rat Human +DTXSID9027368 TK.Half.Life NA 0.8084 hours 1compartment NA NA Human Human +DTXSID9027368 Css NA 0.07815 mg/L 3compartmentss NA 50% Human Human +DTXSID9027368 Css NA 0.6349 mg/L 3compartmentss NA 95% Human Human +DTXSID9027368 Css NA 0.05572 mg/L PBTK NA 50% Human Human +DTXSID9027368 Css NA 0.4107 mg/L PBTK NA 95% Human Human +DTXSID9027368 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027368 Fup 0.432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027368 Vd NA 0.4256 L/kg 1compartment NA NA Rat Human DTXSID9027368 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027368 TK.Half.Life NA 0.4584 hours 1compartment NA NA Rat Human -DTXSID9027368 Css NA 0.1175 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027368 Css NA 0.554 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027368 Css NA 0.07318 mg/L PBTK NA 50% Rat Human -DTXSID9027368 Css NA 0.3267 mg/L PBTK NA 95% Rat Human +DTXSID9027368 TK.Half.Life NA 0.4536 hours 1compartment NA NA Rat Human +DTXSID9027368 Css NA 0.0007148 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027368 Css NA 0.004858 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027368 Css NA 0.0004886 mg/L PBTK NA 50% Rat Human +DTXSID9027368 Css NA 0.002975 mg/L PBTK NA 95% Rat Human +DTXSID90274238 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90274238 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90274238 Vd NA 0.7305 L/kg 1compartment NA NA Human Human +DTXSID90274238 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90274238 TK.Half.Life NA 8.054 hours 1compartment NA NA Human Human +DTXSID90274238 Css NA 1.048 mg/L 3compartmentss NA 50% Human Human +DTXSID90274238 Css NA 7.343 mg/L 3compartmentss NA 95% Human Human +DTXSID90274238 Css NA 0.8472 mg/L PBTK NA 50% Human Human +DTXSID90274238 Css NA 4.645 mg/L PBTK NA 95% Human Human +DTXSID90274238 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90274238 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90274238 Vd NA 0.7293 L/kg 1compartment NA NA Rat Human +DTXSID90274238 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90274238 TK.Half.Life NA 2.725 hours 1compartment NA NA Rat Human +DTXSID90274238 Css NA 0.0204 mg/L 3compartmentss NA 50% Rat Human +DTXSID90274238 Css NA 0.1731 mg/L 3compartmentss NA 95% Rat Human +DTXSID90274238 Css NA 0.01564 mg/L PBTK NA 50% Rat Human +DTXSID90274238 Css NA 0.1088 mg/L PBTK NA 95% Rat Human DTXSID9027441 Clint 807 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9027441 Fup 1.37e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9027441 Vd NA 4.341 L/kg 1compartment NA NA Human Human +DTXSID9027441 Vd NA 4.41 L/kg 1compartment NA NA Human Human DTXSID9027441 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027441 TK.Half.Life NA 8.314 hours 1compartment NA NA Human Human -DTXSID9027441 Css NA 0.115 mg/L 3compartmentss NA 50% Human Human -DTXSID9027441 Css NA 0.6192 mg/L 3compartmentss NA 95% Human Human -DTXSID9027441 Css NA 0.08976 mg/L PBTK NA 50% Human Human -DTXSID9027441 Css NA 0.4904 mg/L PBTK NA 95% Human Human +DTXSID9027441 TK.Half.Life NA 8.428 hours 1compartment NA NA Human Human +DTXSID9027441 Css NA 0.1101 mg/L 3compartmentss NA 50% Human Human +DTXSID9027441 Css NA 0.6538 mg/L 3compartmentss NA 95% Human Human +DTXSID9027441 Css NA 0.08612 mg/L PBTK NA 50% Human Human +DTXSID9027441 Css NA 0.5137 mg/L PBTK NA 95% Human Human DTXSID9027441 Clint 807 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9027441 Fup 1.37e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9027441 Vd NA 3.295 L/kg 1compartment NA NA Rat Human +DTXSID9027441 Vd NA 3.349 L/kg 1compartment NA NA Rat Human DTXSID9027441 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027441 TK.Half.Life NA 3.792 hours 1compartment NA NA Rat Human -DTXSID9027441 Css NA 0.06468 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027441 Css NA 0.2937 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027441 Css NA 0.0489 mg/L PBTK NA 50% Rat Human -DTXSID9027441 Css NA 0.2211 mg/L PBTK NA 95% Rat Human -DTXSID9027443 Clint NA 0.8501 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027443 Fup NA 0.6849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027443 Vd NA 0.8189 L/kg 1compartment NA NA Human Human -DTXSID9027443 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027443 TK.Half.Life NA 3.426 hours 1compartment NA NA Human Human -DTXSID9027443 Css NA 0.4603 mg/L 3compartmentss NA 50% Human Human -DTXSID9027443 Css NA 3.148 mg/L 3compartmentss NA 95% Human Human -DTXSID9027443 Css NA 0.379 mg/L PBTK NA 50% Human Human -DTXSID9027443 Css NA 2.025 mg/L PBTK NA 95% Human Human -DTXSID9027443 Clint NA 0.8501 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027443 Fup NA 0.6849 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027443 Vd NA 0.8047 L/kg 1compartment NA NA Rat Human +DTXSID9027441 TK.Half.Life NA 3.849 hours 1compartment NA NA Rat Human +DTXSID9027441 Css NA 0.01428 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027441 Css NA 0.07013 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027441 Css NA 0.01123 mg/L PBTK NA 50% Rat Human +DTXSID9027441 Css NA 0.05609 mg/L PBTK NA 95% Rat Human +DTXSID9027443 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027443 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027443 Vd NA 1.11 L/kg 1compartment NA NA Human Human +DTXSID9027443 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9027443 TK.Half.Life NA 11.27 hours 1compartment NA NA Human Human +DTXSID9027443 Css NA 1.056 mg/L 3compartmentss NA 50% Human Human +DTXSID9027443 Css NA 7.242 mg/L 3compartmentss NA 95% Human Human +DTXSID9027443 Css NA 0.9054 mg/L PBTK NA 50% Human Human +DTXSID9027443 Css NA 4.751 mg/L PBTK NA 95% Human Human +DTXSID9027443 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027443 Fup 0.677 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027443 Vd NA 1.021 L/kg 1compartment NA NA Rat Human DTXSID9027443 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027443 TK.Half.Life NA 1.578 hours 1compartment NA NA Rat Human -DTXSID9027443 Css NA 0.1694 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027443 Css NA 1.161 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027443 Css NA 0.1361 mg/L PBTK NA 50% Rat Human -DTXSID9027443 Css NA 0.6893 mg/L PBTK NA 95% Rat Human -DTXSID9027520 Clint NA 168.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027520 Fup NA 0.1963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027520 Vd NA 1.709 L/kg 1compartment NA NA Human Human +DTXSID9027443 TK.Half.Life NA 3.375 hours 1compartment NA NA Rat Human +DTXSID9027443 Css NA 0.064 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027443 Css NA 0.412 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027443 Css NA 0.05512 mg/L PBTK NA 50% Rat Human +DTXSID9027443 Css NA 0.2572 mg/L PBTK NA 95% Rat Human +DTXSID9027520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027520 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027520 Vd NA 1.794 L/kg 1compartment NA NA Human Human DTXSID9027520 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027520 TK.Half.Life NA 1.57 hours 1compartment NA NA Human Human -DTXSID9027520 Css NA 0.01888 mg/L 3compartmentss NA 50% Human Human -DTXSID9027520 Css NA 0.1306 mg/L 3compartmentss NA 95% Human Human -DTXSID9027520 Css NA 0.01361 mg/L PBTK NA 50% Human Human -DTXSID9027520 Css NA 0.08942 mg/L PBTK NA 95% Human Human -DTXSID9027520 Clint NA 168.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027520 Fup NA 0.1963 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027520 Vd NA 1.334 L/kg 1compartment NA NA Rat Human +DTXSID9027520 TK.Half.Life NA 3.253 hours 1compartment NA NA Human Human +DTXSID9027520 Css NA 0.127 mg/L 3compartmentss NA 50% Human Human +DTXSID9027520 Css NA 0.8664 mg/L 3compartmentss NA 95% Human Human +DTXSID9027520 Css NA 0.09243 mg/L PBTK NA 50% Human Human +DTXSID9027520 Css NA 0.5754 mg/L PBTK NA 95% Human Human +DTXSID9027520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027520 Fup 0.216 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027520 Vd NA 1.401 L/kg 1compartment NA NA Rat Human DTXSID9027520 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027520 TK.Half.Life NA 0.5484 hours 1compartment NA NA Rat Human -DTXSID9027520 Css NA 0.01038 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027520 Css NA 0.06032 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027520 Css NA 0.007154 mg/L PBTK NA 50% Rat Human -DTXSID9027520 Css NA 0.04031 mg/L PBTK NA 95% Rat Human +DTXSID9027520 TK.Half.Life NA 1.187 hours 1compartment NA NA Rat Human +DTXSID9027520 Css NA 0.01587 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027520 Css NA 0.08227 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027520 Css NA 0.01151 mg/L PBTK NA 50% Rat Human +DTXSID9027520 Css NA 0.05595 mg/L PBTK NA 95% Rat Human DTXSID9027522 Clint 5.87 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9027522 Fup 0.0223 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9027522 Vd NA 2.298 L/kg 1compartment NA NA Human Human -DTXSID9027522 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID9027522 TK.Half.Life NA 81.73 hours 1compartment NA NA Human Human -DTXSID9027522 Css NA 4.565 mg/L 3compartmentss NA 50% Human Human -DTXSID9027522 Css NA 27.57 mg/L 3compartmentss NA 95% Human Human -DTXSID9027522 Css NA 3.04 mg/L PBTK NA 50% Human Human -DTXSID9027522 Css NA 17.67 mg/L PBTK NA 95% Human Human +DTXSID9027522 Vd NA 6.876 L/kg 1compartment NA NA Human Human +DTXSID9027522 Days.Css NA 179 Days PBTK NA NA Human Human +DTXSID9027522 TK.Half.Life NA 743.3 hours 1compartment NA NA Human Human +DTXSID9027522 Css NA 9.271 mg/L 3compartmentss NA 50% Human Human +DTXSID9027522 Css NA 57.82 mg/L 3compartmentss NA 95% Human Human +DTXSID9027522 Css NA 8.725 mg/L PBTK NA 50% Human Human +DTXSID9027522 Css NA 51.29 mg/L PBTK NA 95% Human Human DTXSID9027522 Clint 5.87 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9027522 Fup 0.0223 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9027522 Vd NA 1.713 L/kg 1compartment NA NA Rat Human -DTXSID9027522 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID9027522 TK.Half.Life NA 21.82 hours 1compartment NA NA Rat Human -DTXSID9027522 Css NA 2.49 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027522 Css NA 11.16 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027522 Css NA 1.566 mg/L PBTK NA 50% Rat Human -DTXSID9027522 Css NA 6.814 mg/L PBTK NA 95% Rat Human -DTXSID9027528 Clint NA 36.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027528 Fup NA 0.8992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027528 Vd NA 1.409 L/kg 1compartment NA NA Human Human -DTXSID9027528 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027528 TK.Half.Life NA 0.8894 hours 1compartment NA NA Human Human -DTXSID9027528 Css NA 0.01381 mg/L 3compartmentss NA 50% Human Human -DTXSID9027528 Css NA 0.1091 mg/L 3compartmentss NA 95% Human Human -DTXSID9027528 Css NA 0.01263 mg/L PBTK NA 50% Human Human -DTXSID9027528 Css NA 0.0871 mg/L PBTK NA 95% Human Human -DTXSID9027528 Clint NA 36.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027528 Fup NA 0.8992 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027528 Vd NA 1.294 L/kg 1compartment NA NA Rat Human -DTXSID9027528 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027528 TK.Half.Life NA 0.3759 hours 1compartment NA NA Rat Human -DTXSID9027528 Css NA 0.007054 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027528 Css NA 0.04619 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027528 Css NA 0.006506 mg/L PBTK NA 50% Rat Human -DTXSID9027528 Css NA 0.03784 mg/L PBTK NA 95% Rat Human -DTXSID9027570 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027570 Fup NA 0.898 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027570 Vd NA 1.086 L/kg 1compartment NA NA Human Human +DTXSID9027522 Vd NA 5.324 L/kg 1compartment NA NA Rat Human +DTXSID9027522 Days.Css NA 101 Days PBTK NA NA Rat Human +DTXSID9027522 TK.Half.Life NA 98.91 hours 1compartment NA NA Rat Human +DTXSID9027522 Css NA 1.185 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027522 Css NA 5.783 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027522 Css NA 1.136 mg/L PBTK NA 50% Rat Human +DTXSID9027522 Css NA 5.782 mg/L PBTK NA 95% Rat Human +DTXSID9027570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027570 Fup 0.674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027570 Vd NA 1.293 L/kg 1compartment NA NA Human Human DTXSID9027570 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027570 TK.Half.Life NA 8.042 hours 1compartment NA NA Human Human -DTXSID9027570 Css NA 0.8814 mg/L 3compartmentss NA 50% Human Human -DTXSID9027570 Css NA 4.978 mg/L 3compartmentss NA 95% Human Human -DTXSID9027570 Css NA 0.7798 mg/L PBTK NA 50% Human Human -DTXSID9027570 Css NA 3.367 mg/L PBTK NA 95% Human Human -DTXSID9027570 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027570 Fup NA 0.898 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027570 Vd NA 1.056 L/kg 1compartment NA NA Rat Human +DTXSID9027570 TK.Half.Life NA 1.077 hours 1compartment NA NA Human Human +DTXSID9027570 Css NA 0.0292 mg/L 3compartmentss NA 50% Human Human +DTXSID9027570 Css NA 0.3257 mg/L 3compartmentss NA 95% Human Human +DTXSID9027570 Css NA 0.02518 mg/L PBTK NA 50% Human Human +DTXSID9027570 Css NA 0.2389 mg/L PBTK NA 95% Human Human +DTXSID9027570 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027570 Fup 0.674 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027570 Vd NA 1.163 L/kg 1compartment NA NA Rat Human DTXSID9027570 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027570 TK.Half.Life NA 2.61 hours 1compartment NA NA Rat Human -DTXSID9027570 Css NA 0.2205 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027570 Css NA 1.288 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027570 Css NA 0.192 mg/L PBTK NA 50% Rat Human -DTXSID9027570 Css NA 0.7979 mg/L PBTK NA 95% Rat Human -DTXSID9027603 Clint NA 2.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027603 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027603 Vd NA 0.8249 L/kg 1compartment NA NA Human Human +DTXSID9027570 TK.Half.Life NA 0.4687 hours 1compartment NA NA Rat Human +DTXSID9027570 Css NA 0.003456 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027570 Css NA 0.03322 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027570 Css NA 0.003085 mg/L PBTK NA 50% Rat Human +DTXSID9027570 Css NA 0.02289 mg/L PBTK NA 95% Rat Human +DTXSID9027603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027603 Fup 0.565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027603 Vd NA 0.6126 L/kg 1compartment NA NA Human Human DTXSID9027603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027603 TK.Half.Life NA 1.269 hours 1compartment NA NA Human Human -DTXSID9027603 Css NA 0.1547 mg/L 3compartmentss NA 50% Human Human -DTXSID9027603 Css NA 1.271 mg/L 3compartmentss NA 95% Human Human -DTXSID9027603 Css NA 0.1296 mg/L PBTK NA 50% Human Human -DTXSID9027603 Css NA 0.8681 mg/L PBTK NA 95% Human Human -DTXSID9027603 Clint NA 2.76 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027603 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027603 Vd NA 0.8564 L/kg 1compartment NA NA Rat Human +DTXSID9027603 TK.Half.Life NA 7.024 hours 1compartment NA NA Human Human +DTXSID9027603 Css NA 1.296 mg/L 3compartmentss NA 50% Human Human +DTXSID9027603 Css NA 8.517 mg/L 3compartmentss NA 95% Human Human +DTXSID9027603 Css NA 1.008 mg/L PBTK NA 50% Human Human +DTXSID9027603 Css NA 5.253 mg/L PBTK NA 95% Human Human +DTXSID9027603 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027603 Fup 0.565 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027603 Vd NA 0.6298 L/kg 1compartment NA NA Rat Human DTXSID9027603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027603 TK.Half.Life NA 0.6856 hours 1compartment NA NA Rat Human -DTXSID9027603 Css NA 0.06634 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027603 Css NA 0.4564 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027603 Css NA 0.05546 mg/L PBTK NA 50% Rat Human -DTXSID9027603 Css NA 0.2791 mg/L PBTK NA 95% Rat Human -DTXSID9027738 Clint NA 0.009632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027738 Fup NA 0.0602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027738 Vd NA 10.77 L/kg 1compartment NA NA Human Human -DTXSID9027738 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID9027738 TK.Half.Life NA 296500 hours 1compartment NA NA Human Human -DTXSID9027738 Css NA 1656 mg/L 3compartmentss NA 50% Human Human -DTXSID9027738 Css NA 4309 mg/L 3compartmentss NA 95% Human Human -DTXSID9027738 Css NA 2101 mg/L PBTK NA 50% Human Human -DTXSID9027738 Css NA 4946 mg/L PBTK NA 95% Human Human -DTXSID9027738 Clint NA 0.009632 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027738 Fup NA 0.0602 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027738 Vd NA 8.51 L/kg 1compartment NA NA Rat Human -DTXSID9027738 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID9027738 TK.Half.Life NA 24430 hours 1compartment NA NA Rat Human -DTXSID9027738 Css NA 569.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027738 Css NA 992 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027738 Css NA 729.5 mg/L PBTK NA 50% Rat Human -DTXSID9027738 Css NA 1083 mg/L PBTK NA 95% Rat Human -DTXSID9027863 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027863 Fup NA 0.8561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027863 Vd NA 0.718 L/kg 1compartment NA NA Human Human -DTXSID9027863 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9027863 TK.Half.Life NA 5.428 hours 1compartment NA NA Human Human -DTXSID9027863 Css NA 0.9645 mg/L 3compartmentss NA 50% Human Human -DTXSID9027863 Css NA 5.7 mg/L 3compartmentss NA 95% Human Human -DTXSID9027863 Css NA 0.7876 mg/L PBTK NA 50% Human Human -DTXSID9027863 Css NA 3.639 mg/L PBTK NA 95% Human Human -DTXSID9027863 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027863 Fup NA 0.8561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027863 Vd NA 0.7507 L/kg 1compartment NA NA Rat Human -DTXSID9027863 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9027863 TK.Half.Life NA 1.933 hours 1compartment NA NA Rat Human -DTXSID9027863 Css NA 0.2454 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027863 Css NA 1.42 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027863 Css NA 0.1953 mg/L PBTK NA 50% Rat Human -DTXSID9027863 Css NA 0.8502 mg/L PBTK NA 95% Rat Human -DTXSID9027948 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027948 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9027948 Vd NA 77.33 L/kg 1compartment NA NA Human Human -DTXSID9027948 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID9027948 TK.Half.Life NA 3707000 hours 1compartment NA NA Human Human -DTXSID9027948 Css NA 409.1 mg/L 3compartmentss NA 50% Human Human -DTXSID9027948 Css NA 1077 mg/L 3compartmentss NA 95% Human Human -DTXSID9027948 Css NA 3700 mg/L PBTK NA 50% Human Human -DTXSID9027948 Css NA 7986 mg/L PBTK NA 95% Human Human -DTXSID9027948 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027948 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9027948 Vd NA 66.26 L/kg 1compartment NA NA Rat Human -DTXSID9027948 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID9027948 TK.Half.Life NA 268800 hours 1compartment NA NA Rat Human -DTXSID9027948 Css NA 100.5 mg/L 3compartmentss NA 50% Rat Human -DTXSID9027948 Css NA 175.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID9027948 Css NA 992.8 mg/L PBTK NA 50% Rat Human -DTXSID9027948 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID9029017 Clint NA 137.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029017 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029017 Vd NA 19.37 L/kg 1compartment NA NA Human Human -DTXSID9029017 Days.Css NA 14 Days PBTK NA NA Human Human -DTXSID9029017 TK.Half.Life NA 95.96 hours 1compartment NA NA Human Human -DTXSID9029017 Css NA 0.1904 mg/L 3compartmentss NA 50% Human Human -DTXSID9029017 Css NA 1.15 mg/L 3compartmentss NA 95% Human Human -DTXSID9029017 Css NA 0.3908 mg/L PBTK NA 50% Human Human -DTXSID9029017 Css NA 2.223 mg/L PBTK NA 95% Human Human -DTXSID9029017 Clint NA 137.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029017 Fup NA 0.0076 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029017 Vd NA 15.7 L/kg 1compartment NA NA Rat Human -DTXSID9029017 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID9029017 TK.Half.Life NA 14.83 hours 1compartment NA NA Rat Human -DTXSID9029017 Css NA 0.1003 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029017 Css NA 0.4328 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029017 Css NA 0.2124 mg/L PBTK NA 50% Rat Human -DTXSID9029017 Css NA 0.9051 mg/L PBTK NA 95% Rat Human -DTXSID9029061 Clint NA 38.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029061 Fup NA 0.3831 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029061 Vd NA 2.518 L/kg 1compartment NA NA Human Human -DTXSID9029061 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9029061 TK.Half.Life NA 3.225 hours 1compartment NA NA Human Human -DTXSID9029061 Css NA 0.06842 mg/L 3compartmentss NA 50% Human Human -DTXSID9029061 Css NA 0.4472 mg/L 3compartmentss NA 95% Human Human -DTXSID9029061 Css NA 0.05291 mg/L PBTK NA 50% Human Human -DTXSID9029061 Css NA 0.3232 mg/L PBTK NA 95% Human Human -DTXSID9029061 Clint NA 38.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029061 Fup NA 0.3831 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029061 Vd NA 1.951 L/kg 1compartment NA NA Rat Human -DTXSID9029061 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9029061 TK.Half.Life NA 0.98 hours 1compartment NA NA Rat Human -DTXSID9029061 Css NA 0.03712 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029061 Css NA 0.1949 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029061 Css NA 0.02771 mg/L PBTK NA 50% Rat Human -DTXSID9029061 Css NA 0.1361 mg/L PBTK NA 95% Rat Human +DTXSID9027603 TK.Half.Life NA 2.458 hours 1compartment NA NA Rat Human +DTXSID9027603 Css NA 0.07934 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027603 Css NA 0.5073 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027603 Css NA 0.06103 mg/L PBTK NA 50% Rat Human +DTXSID9027603 Css NA 0.3039 mg/L PBTK NA 95% Rat Human +DTXSID9027653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027653 Fup 0.042 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9027653 Vd NA 3.089 L/kg 1compartment NA NA Human Human +DTXSID9027653 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID9027653 TK.Half.Life NA 65.27 hours 1compartment NA NA Human Human +DTXSID9027653 Css NA 2.456 mg/L 3compartmentss NA 50% Human Human +DTXSID9027653 Css NA 16.03 mg/L 3compartmentss NA 95% Human Human +DTXSID9027653 Css NA 1.71 mg/L PBTK NA 50% Human Human +DTXSID9027653 Css NA 10.61 mg/L PBTK NA 95% Human Human +DTXSID9027653 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027653 Fup 0.042 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9027653 Vd NA 2.315 L/kg 1compartment NA NA Rat Human +DTXSID9027653 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID9027653 TK.Half.Life NA 9.308 hours 1compartment NA NA Rat Human +DTXSID9027653 Css NA 0.3229 mg/L 3compartmentss NA 50% Rat Human +DTXSID9027653 Css NA 1.869 mg/L 3compartmentss NA 95% Rat Human +DTXSID9027653 Css NA 0.2223 mg/L PBTK NA 50% Rat Human +DTXSID9027653 Css NA 1.252 mg/L PBTK NA 95% Rat Human DTXSID9029146 Clint NA 0.05689 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9029146 Fup NA 0.7241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9029146 Vd NA 1.849 L/kg 1compartment NA NA Human Human DTXSID9029146 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID9029146 TK.Half.Life NA 15.11 hours 1compartment NA NA Human Human -DTXSID9029146 Css NA 0.7876 mg/L 3compartmentss NA 50% Human Human -DTXSID9029146 Css NA 5.508 mg/L 3compartmentss NA 95% Human Human -DTXSID9029146 Css NA 0.7783 mg/L PBTK NA 50% Human Human -DTXSID9029146 Css NA 3.732 mg/L PBTK NA 95% Human Human +DTXSID9029146 Css NA 0.6622 mg/L 3compartmentss NA 50% Human Human +DTXSID9029146 Css NA 4.724 mg/L 3compartmentss NA 95% Human Human +DTXSID9029146 Css NA 0.6572 mg/L PBTK NA 50% Human Human +DTXSID9029146 Css NA 3.212 mg/L PBTK NA 95% Human Human DTXSID9029146 Clint NA 0.05689 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9029146 Fup NA 0.7241 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9029146 Vd NA 1.879 L/kg 1compartment NA NA Rat Human DTXSID9029146 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9029146 TK.Half.Life NA 5.471 hours 1compartment NA NA Rat Human -DTXSID9029146 Css NA 0.2111 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029146 Css NA 1.564 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029146 Css NA 0.205 mg/L PBTK NA 50% Rat Human -DTXSID9029146 Css NA 0.9825 mg/L PBTK NA 95% Rat Human +DTXSID9029146 Css NA 0.01336 mg/L 3compartmentss NA 50% Rat Human +DTXSID9029146 Css NA 0.1266 mg/L 3compartmentss NA 95% Rat Human +DTXSID9029146 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID9029146 Css NA 0.08662 mg/L PBTK NA 95% Rat Human DTXSID9029221 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9029221 Fup 0.438 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9029221 Vd NA 0.6478 L/kg 1compartment NA NA Human Human DTXSID9029221 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID9029221 TK.Half.Life NA 9.567 hours 1compartment NA NA Human Human -DTXSID9029221 Css NA 0.4304 mg/L 3compartmentss NA 50% Human Human -DTXSID9029221 Css NA 1.708 mg/L 3compartmentss NA 95% Human Human -DTXSID9029221 Css NA 0.3393 mg/L PBTK NA 50% Human Human -DTXSID9029221 Css NA 1.209 mg/L PBTK NA 95% Human Human +DTXSID9029221 Css NA 0.4244 mg/L 3compartmentss NA 50% Human Human +DTXSID9029221 Css NA 1.78 mg/L 3compartmentss NA 95% Human Human +DTXSID9029221 Css NA 0.3306 mg/L PBTK NA 50% Human Human +DTXSID9029221 Css NA 1.241 mg/L PBTK NA 95% Human Human DTXSID9029221 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9029221 Fup 0.438 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9029221 Vd NA 0.6568 L/kg 1compartment NA NA Rat Human DTXSID9029221 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9029221 TK.Half.Life NA 3.305 hours 1compartment NA NA Rat Human -DTXSID9029221 Css NA 0.1844 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029221 Css NA 0.5425 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029221 Css NA 0.1404 mg/L PBTK NA 50% Rat Human -DTXSID9029221 Css NA 0.3519 mg/L PBTK NA 95% Rat Human -DTXSID9029225 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029225 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029225 Vd NA 1.703 L/kg 1compartment NA NA Human Human -DTXSID9029225 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9029225 TK.Half.Life NA 11.02 hours 1compartment NA NA Human Human -DTXSID9029225 Css NA 0.7117 mg/L 3compartmentss NA 50% Human Human -DTXSID9029225 Css NA 5.274 mg/L 3compartmentss NA 95% Human Human -DTXSID9029225 Css NA 0.6986 mg/L PBTK NA 50% Human Human -DTXSID9029225 Css NA 3.574 mg/L PBTK NA 95% Human Human -DTXSID9029225 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029225 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029225 Vd NA 1.743 L/kg 1compartment NA NA Rat Human +DTXSID9029221 Css NA 0.042 mg/L 3compartmentss NA 50% Rat Human +DTXSID9029221 Css NA 0.1244 mg/L 3compartmentss NA 95% Rat Human +DTXSID9029221 Css NA 0.03274 mg/L PBTK NA 50% Rat Human +DTXSID9029221 Css NA 0.08414 mg/L PBTK NA 95% Rat Human +DTXSID9029225 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029225 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029225 Vd NA 0.568 L/kg 1compartment NA NA Human Human +DTXSID9029225 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9029225 TK.Half.Life NA 5.295 hours 1compartment NA NA Human Human +DTXSID9029225 Css NA 0.9604 mg/L 3compartmentss NA 50% Human Human +DTXSID9029225 Css NA 6.369 mg/L 3compartmentss NA 95% Human Human +DTXSID9029225 Css NA 0.7536 mg/L PBTK NA 50% Human Human +DTXSID9029225 Css NA 4.005 mg/L PBTK NA 95% Human Human +DTXSID9029225 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029225 Fup 0.694 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029225 Vd NA 0.607 L/kg 1compartment NA NA Rat Human DTXSID9029225 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9029225 TK.Half.Life NA 3.842 hours 1compartment NA NA Rat Human -DTXSID9029225 Css NA 0.1754 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029225 Css NA 1.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029225 Css NA 0.172 mg/L PBTK NA 50% Rat Human -DTXSID9029225 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID9029275 Clint NA 0.09535 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029275 Fup NA 0.8547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029275 Vd NA 1.68 L/kg 1compartment NA NA Human Human -DTXSID9029275 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9029275 TK.Half.Life NA 11 hours 1compartment NA NA Human Human -DTXSID9029275 Css NA 0.6882 mg/L 3compartmentss NA 50% Human Human -DTXSID9029275 Css NA 4.662 mg/L 3compartmentss NA 95% Human Human -DTXSID9029275 Css NA 0.669 mg/L PBTK NA 50% Human Human -DTXSID9029275 Css NA 3.199 mg/L PBTK NA 95% Human Human -DTXSID9029275 Clint NA 0.09535 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029275 Fup NA 0.8547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029275 Vd NA 1.716 L/kg 1compartment NA NA Rat Human +DTXSID9029225 TK.Half.Life NA 1.928 hours 1compartment NA NA Rat Human +DTXSID9029225 Css NA 0.01847 mg/L 3compartmentss NA 50% Rat Human +DTXSID9029225 Css NA 0.1531 mg/L 3compartmentss NA 95% Rat Human +DTXSID9029225 Css NA 0.01376 mg/L PBTK NA 50% Rat Human +DTXSID9029225 Css NA 0.09554 mg/L PBTK NA 95% Rat Human +DTXSID9029227 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029227 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029227 Vd NA 2.951 L/kg 1compartment NA NA Human Human +DTXSID9029227 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID9029227 TK.Half.Life NA 40.87 hours 1compartment NA NA Human Human +DTXSID9029227 Css NA 1.711 mg/L 3compartmentss NA 50% Human Human +DTXSID9029227 Css NA 11.13 mg/L 3compartmentss NA 95% Human Human +DTXSID9029227 Css NA 1.17 mg/L PBTK NA 50% Human Human +DTXSID9029227 Css NA 7.432 mg/L PBTK NA 95% Human Human +DTXSID9029227 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029227 Fup 0.0406 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029227 Vd NA 2.212 L/kg 1compartment NA NA Rat Human +DTXSID9029227 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9029227 TK.Half.Life NA 7.007 hours 1compartment NA NA Rat Human +DTXSID9029227 Css NA 0.2202 mg/L 3compartmentss NA 50% Rat Human +DTXSID9029227 Css NA 1.248 mg/L 3compartmentss NA 95% Rat Human +DTXSID9029227 Css NA 0.1488 mg/L PBTK NA 50% Rat Human +DTXSID9029227 Css NA 0.8213 mg/L PBTK NA 95% Rat Human +DTXSID9029275 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029275 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029275 Vd NA 1.166 L/kg 1compartment NA NA Human Human +DTXSID9029275 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9029275 TK.Half.Life NA 24.73 hours 1compartment NA NA Human Human +DTXSID9029275 Css NA 1.843 mg/L 3compartmentss NA 50% Human Human +DTXSID9029275 Css NA 7.914 mg/L 3compartmentss NA 95% Human Human +DTXSID9029275 Css NA 1.482 mg/L PBTK NA 50% Human Human +DTXSID9029275 Css NA 5.287 mg/L PBTK NA 95% Human Human +DTXSID9029275 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029275 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029275 Vd NA 1.17 L/kg 1compartment NA NA Rat Human DTXSID9029275 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9029275 TK.Half.Life NA 4.114 hours 1compartment NA NA Rat Human -DTXSID9029275 Css NA 0.1857 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029275 Css NA 1.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029275 Css NA 0.1796 mg/L PBTK NA 50% Rat Human -DTXSID9029275 Css NA 0.7712 mg/L PBTK NA 95% Rat Human +DTXSID9029275 TK.Half.Life NA 8.457 hours 1compartment NA NA Rat Human +DTXSID9029275 Css NA 0.03323 mg/L 3compartmentss NA 50% Rat Human +DTXSID9029275 Css NA 0.2123 mg/L 3compartmentss NA 95% Rat Human +DTXSID9029275 Css NA 0.02564 mg/L PBTK NA 50% Rat Human +DTXSID9029275 Css NA 0.1425 mg/L PBTK NA 95% Rat Human +DTXSID9029277 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029277 Fup 0.084 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029277 Vd NA 0.2111 L/kg 1compartment NA NA Human Human +DTXSID9029277 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9029277 TK.Half.Life NA 1.425 hours 1compartment NA NA Human Human +DTXSID9029277 Css NA 0.5565 mg/L 3compartmentss NA 50% Human Human +DTXSID9029277 Css NA 4.324 mg/L 3compartmentss NA 95% Human Human +DTXSID9029277 Css NA 0.3304 mg/L PBTK NA 50% Human Human +DTXSID9029277 Css NA 2.554 mg/L PBTK NA 95% Human Human +DTXSID9029277 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029277 Fup 0.084 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029277 Vd NA 0.2141 L/kg 1compartment NA NA Rat Human +DTXSID9029277 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9029277 TK.Half.Life NA 0.8908 hours 1compartment NA NA Rat Human +DTXSID9029277 Css NA 0.005723 mg/L 3compartmentss NA 50% Rat Human +DTXSID9029277 Css NA 0.03693 mg/L 3compartmentss NA 95% Rat Human +DTXSID9029277 Css NA 0.003216 mg/L PBTK NA 50% Rat Human +DTXSID9029277 Css NA 0.02022 mg/L PBTK NA 95% Rat Human DTXSID9029279 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9029279 Fup NA 0.3198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029279 Vd NA 0.4169 L/kg 1compartment NA NA Human Human +DTXSID9029279 Vd NA 0.3865 L/kg 1compartment NA NA Human Human DTXSID9029279 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9029279 TK.Half.Life NA 8.434 hours 1compartment NA NA Human Human -DTXSID9029279 Css NA 2.376 mg/L 3compartmentss NA 50% Human Human -DTXSID9029279 Css NA 9.51 mg/L 3compartmentss NA 95% Human Human -DTXSID9029279 Css NA 1.659 mg/L PBTK NA 50% Human Human -DTXSID9029279 Css NA 5.882 mg/L PBTK NA 95% Human Human +DTXSID9029279 TK.Half.Life NA 7.82 hours 1compartment NA NA Human Human +DTXSID9029279 Css NA 2.044 mg/L 3compartmentss NA 50% Human Human +DTXSID9029279 Css NA 8.274 mg/L 3compartmentss NA 95% Human Human +DTXSID9029279 Css NA 1.404 mg/L PBTK NA 50% Human Human +DTXSID9029279 Css NA 5.11 mg/L PBTK NA 95% Human Human DTXSID9029279 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9029279 Fup NA 0.3198 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029279 Vd NA 0.4337 L/kg 1compartment NA NA Rat Human +DTXSID9029279 Vd NA 0.4077 L/kg 1compartment NA NA Rat Human DTXSID9029279 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9029279 TK.Half.Life NA 2.992 hours 1compartment NA NA Rat Human -DTXSID9029279 Css NA 0.6619 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029279 Css NA 2.245 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029279 Css NA 0.4351 mg/L PBTK NA 50% Rat Human -DTXSID9029279 Css NA 1.301 mg/L PBTK NA 95% Rat Human -DTXSID9029300 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029300 Fup NA 0.1163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029300 Vd NA 1.58 L/kg 1compartment NA NA Human Human -DTXSID9029300 Days.Css NA 25 Days PBTK NA NA Human Human -DTXSID9029300 TK.Half.Life NA 125.3 hours 1compartment NA NA Human Human -DTXSID9029300 Css NA 10.96 mg/L 3compartmentss NA 50% Human Human -DTXSID9029300 Css NA 44.91 mg/L 3compartmentss NA 95% Human Human -DTXSID9029300 Css NA 7.39 mg/L PBTK NA 50% Human Human -DTXSID9029300 Css NA 27.41 mg/L PBTK NA 95% Human Human -DTXSID9029300 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029300 Fup NA 0.1163 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029300 Vd NA 1.213 L/kg 1compartment NA NA Rat Human -DTXSID9029300 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID9029300 TK.Half.Life NA 25.33 hours 1compartment NA NA Rat Human -DTXSID9029300 Css NA 3.027 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029300 Css NA 10.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029300 Css NA 1.928 mg/L PBTK NA 50% Rat Human -DTXSID9029300 Css NA 5.885 mg/L PBTK NA 95% Rat Human -DTXSID9029302 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029302 Fup NA 0.1424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029302 Vd NA 3.004 L/kg 1compartment NA NA Human Human +DTXSID9029279 TK.Half.Life NA 2.812 hours 1compartment NA NA Rat Human +DTXSID9029279 Css NA 0.03714 mg/L 3compartmentss NA 50% Rat Human +DTXSID9029279 Css NA 0.2187 mg/L 3compartmentss NA 95% Rat Human +DTXSID9029279 Css NA 0.0245 mg/L PBTK NA 50% Rat Human +DTXSID9029279 Css NA 0.1346 mg/L PBTK NA 95% Rat Human +DTXSID9029302 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029302 Fup 0.0968 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029302 Vd NA 2.975 L/kg 1compartment NA NA Human Human DTXSID9029302 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9029302 TK.Half.Life NA 27.97 hours 1compartment NA NA Human Human -DTXSID9029302 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human -DTXSID9029302 Css NA 6.618 mg/L 3compartmentss NA 95% Human Human -DTXSID9029302 Css NA 0.7581 mg/L PBTK NA 50% Human Human -DTXSID9029302 Css NA 4.47 mg/L PBTK NA 95% Human Human -DTXSID9029302 Clint NA 18.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029302 Fup NA 0.1424 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029302 Vd NA 2.259 L/kg 1compartment NA NA Rat Human +DTXSID9029302 TK.Half.Life NA 27.36 hours 1compartment NA NA Human Human +DTXSID9029302 Css NA 1.047 mg/L 3compartmentss NA 50% Human Human +DTXSID9029302 Css NA 6.64 mg/L 3compartmentss NA 95% Human Human +DTXSID9029302 Css NA 0.7294 mg/L PBTK NA 50% Human Human +DTXSID9029302 Css NA 4.419 mg/L PBTK NA 95% Human Human +DTXSID9029302 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029302 Fup 0.0968 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029302 Vd NA 2.235 L/kg 1compartment NA NA Rat Human DTXSID9029302 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9029302 TK.Half.Life NA 4.728 hours 1compartment NA NA Rat Human -DTXSID9029302 Css NA 0.596 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029302 Css NA 2.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029302 Css NA 0.4 mg/L PBTK NA 50% Rat Human -DTXSID9029302 Css NA 1.907 mg/L PBTK NA 95% Rat Human -DTXSID9029304 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029304 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029304 Vd NA 5.144 L/kg 1compartment NA NA Human Human -DTXSID9029304 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID9029304 TK.Half.Life NA 244900 hours 1compartment NA NA Human Human -DTXSID9029304 Css NA 4461 mg/L 3compartmentss NA 50% Human Human -DTXSID9029304 Css NA 10130 mg/L 3compartmentss NA 95% Human Human -DTXSID9029304 Css NA 3670 mg/L PBTK NA 50% Human Human -DTXSID9029304 Css NA 7880 mg/L PBTK NA 95% Human Human -DTXSID9029304 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029304 Fup NA 0.0173 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029304 Vd NA 3.933 L/kg 1compartment NA NA Rat Human -DTXSID9029304 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID9029304 TK.Half.Life NA 15590 hours 1compartment NA NA Rat Human -DTXSID9029304 Css NA 1227 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029304 Css NA 1807 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029304 Css NA 982.5 mg/L PBTK NA 50% Rat Human -DTXSID9029304 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID9029649 Clint NA 4.945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029649 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029649 Vd NA 2.797 L/kg 1compartment NA NA Human Human -DTXSID9029649 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9029649 TK.Half.Life NA 2.828 hours 1compartment NA NA Human Human -DTXSID9029649 Css NA 0.06973 mg/L 3compartmentss NA 50% Human Human -DTXSID9029649 Css NA 0.7146 mg/L 3compartmentss NA 95% Human Human -DTXSID9029649 Css NA 0.07955 mg/L PBTK NA 50% Human Human -DTXSID9029649 Css NA 0.6109 mg/L PBTK NA 95% Human Human -DTXSID9029649 Clint NA 4.945 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029649 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029649 Vd NA 2.83 L/kg 1compartment NA NA Rat Human +DTXSID9029302 TK.Half.Life NA 4.751 hours 1compartment NA NA Rat Human +DTXSID9029302 Css NA 0.1349 mg/L 3compartmentss NA 50% Rat Human +DTXSID9029302 Css NA 0.7499 mg/L 3compartmentss NA 95% Rat Human +DTXSID9029302 Css NA 0.09316 mg/L PBTK NA 50% Rat Human +DTXSID9029302 Css NA 0.5028 mg/L PBTK NA 95% Rat Human +DTXSID90296016 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90296016 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90296016 Vd NA 0.4397 L/kg 1compartment NA NA Human Human +DTXSID90296016 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90296016 TK.Half.Life NA 1.088 hours 1compartment NA NA Human Human +DTXSID90296016 Css NA 0.2159 mg/L 3compartmentss NA 50% Human Human +DTXSID90296016 Css NA 1.367 mg/L 3compartmentss NA 95% Human Human +DTXSID90296016 Css NA 0.1512 mg/L PBTK NA 50% Human Human +DTXSID90296016 Css NA 0.8871 mg/L PBTK NA 95% Human Human +DTXSID90296016 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90296016 Fup 0.307 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90296016 Vd NA 0.4449 L/kg 1compartment NA NA Rat Human +DTXSID90296016 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90296016 TK.Half.Life NA 0.6273 hours 1compartment NA NA Rat Human +DTXSID90296016 Css NA 0.02462 mg/L 3compartmentss NA 50% Rat Human +DTXSID90296016 Css NA 0.1158 mg/L 3compartmentss NA 95% Rat Human +DTXSID90296016 Css NA 0.01708 mg/L PBTK NA 50% Rat Human +DTXSID90296016 Css NA 0.07247 mg/L PBTK NA 95% Rat Human +DTXSID9029649 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029649 Fup 0.688 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9029649 Vd NA 2.024 L/kg 1compartment NA NA Human Human +DTXSID9029649 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9029649 TK.Half.Life NA 19.04 hours 1compartment NA NA Human Human +DTXSID9029649 Css NA 0.855 mg/L 3compartmentss NA 50% Human Human +DTXSID9029649 Css NA 6.553 mg/L 3compartmentss NA 95% Human Human +DTXSID9029649 Css NA 0.8765 mg/L PBTK NA 50% Human Human +DTXSID9029649 Css NA 4.442 mg/L PBTK NA 95% Human Human +DTXSID9029649 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029649 Fup 0.688 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9029649 Vd NA 2.039 L/kg 1compartment NA NA Rat Human DTXSID9029649 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9029649 TK.Half.Life NA 1.557 hours 1compartment NA NA Rat Human -DTXSID9029649 Css NA 0.03142 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029649 Css NA 0.2668 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029649 Css NA 0.03695 mg/L PBTK NA 50% Rat Human -DTXSID9029649 Css NA 0.2006 mg/L PBTK NA 95% Rat Human -DTXSID9029691 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029691 Fup NA 0.7231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029691 Vd NA 0.5748 L/kg 1compartment NA NA Human Human -DTXSID9029691 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9029691 TK.Half.Life NA 5.142 hours 1compartment NA NA Human Human -DTXSID9029691 Css NA 1.112 mg/L 3compartmentss NA 50% Human Human -DTXSID9029691 Css NA 6.84 mg/L 3compartmentss NA 95% Human Human -DTXSID9029691 Css NA 0.8676 mg/L PBTK NA 50% Human Human -DTXSID9029691 Css NA 4.217 mg/L PBTK NA 95% Human Human -DTXSID9029691 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029691 Fup NA 0.7231 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029691 Vd NA 0.6163 L/kg 1compartment NA NA Rat Human -DTXSID9029691 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9029691 TK.Half.Life NA 1.879 hours 1compartment NA NA Rat Human -DTXSID9029691 Css NA 0.2872 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029691 Css NA 1.754 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029691 Css NA 0.2162 mg/L PBTK NA 50% Rat Human -DTXSID9029691 Css NA 1.026 mg/L PBTK NA 95% Rat Human -DTXSID9029695 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029695 Fup NA 0.2389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9029695 Vd NA 0.312 L/kg 1compartment NA NA Human Human -DTXSID9029695 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9029695 TK.Half.Life NA 8.448 hours 1compartment NA NA Human Human -DTXSID9029695 Css NA 3.391 mg/L 3compartmentss NA 50% Human Human -DTXSID9029695 Css NA 12.16 mg/L 3compartmentss NA 95% Human Human -DTXSID9029695 Css NA 2.208 mg/L PBTK NA 50% Human Human -DTXSID9029695 Css NA 7.429 mg/L PBTK NA 95% Human Human -DTXSID9029695 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029695 Fup NA 0.2389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9029695 Vd NA 0.3339 L/kg 1compartment NA NA Rat Human -DTXSID9029695 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9029695 TK.Half.Life NA 3.082 hours 1compartment NA NA Rat Human -DTXSID9029695 Css NA 0.9414 mg/L 3compartmentss NA 50% Rat Human -DTXSID9029695 Css NA 2.841 mg/L 3compartmentss NA 95% Rat Human -DTXSID9029695 Css NA 0.5795 mg/L PBTK NA 50% Rat Human -DTXSID9029695 Css NA 1.611 mg/L PBTK NA 95% Rat Human +DTXSID9029649 TK.Half.Life NA 6.533 hours 1compartment NA NA Rat Human +DTXSID9029649 Css NA 0.04934 mg/L 3compartmentss NA 50% Rat Human +DTXSID9029649 Css NA 0.3613 mg/L 3compartmentss NA 95% Rat Human +DTXSID9029649 Css NA 0.05182 mg/L PBTK NA 50% Rat Human +DTXSID9029649 Css NA 0.24 mg/L PBTK NA 95% Rat Human +DTXSID9030048 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9030048 Fup NA 0.018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9030048 Vd NA 27.29 L/kg 1compartment NA NA Human Human +DTXSID9030048 Days.Css NA 3276 Days PBTK NA NA Human Human +DTXSID9030048 TK.Half.Life NA 1298000 hours 1compartment NA NA Human Human +DTXSID9030048 Css NA 1072 mg/L 3compartmentss NA 50% Human Human +DTXSID9030048 Css NA 2817 mg/L 3compartmentss NA 95% Human Human +DTXSID9030048 Css NA 3119 mg/L PBTK NA 50% Human Human +DTXSID9030048 Css NA 6926 mg/L PBTK NA 95% Human Human +DTXSID9030048 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9030048 Fup NA 0.018 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9030048 Vd NA 22.45 L/kg 1compartment NA NA Rat Human +DTXSID9030048 Days.Css NA 5901 Days PBTK NA NA Rat Human +DTXSID9030048 TK.Half.Life NA 88870 hours 1compartment NA NA Rat Human +DTXSID9030048 Css NA 16.38 mg/L 3compartmentss NA 50% Rat Human +DTXSID9030048 Css NA 81.96 mg/L 3compartmentss NA 95% Rat Human +DTXSID9030048 Css NA 50.44 mg/L PBTK NA 50% Rat Human +DTXSID9030048 Css NA 227 mg/L PBTK NA 95% Rat Human DTXSID9030707 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9030707 Fup NA 0.2466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9030707 Vd NA 2.524 L/kg 1compartment NA NA Human Human -DTXSID9030707 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID9030707 TK.Half.Life NA 69.04 hours 1compartment NA NA Human Human -DTXSID9030707 Css NA 2.308 mg/L 3compartmentss NA 50% Human Human -DTXSID9030707 Css NA 10.41 mg/L 3compartmentss NA 95% Human Human -DTXSID9030707 Css NA 2.218 mg/L PBTK NA 50% Human Human -DTXSID9030707 Css NA 7.728 mg/L PBTK NA 95% Human Human +DTXSID9030707 Vd NA 1.391 L/kg 1compartment NA NA Human Human +DTXSID9030707 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID9030707 TK.Half.Life NA 36.5 hours 1compartment NA NA Human Human +DTXSID9030707 Css NA 2.213 mg/L 3compartmentss NA 50% Human Human +DTXSID9030707 Css NA 9.395 mg/L 3compartmentss NA 95% Human Human +DTXSID9030707 Css NA 1.808 mg/L PBTK NA 50% Human Human +DTXSID9030707 Css NA 6.42 mg/L PBTK NA 95% Human Human DTXSID9030707 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9030707 Fup NA 0.2466 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9030707 Vd NA 2.52 L/kg 1compartment NA NA Rat Human -DTXSID9030707 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9030707 TK.Half.Life NA 22.76 hours 1compartment NA NA Rat Human -DTXSID9030707 Css NA 0.6152 mg/L 3compartmentss NA 50% Rat Human -DTXSID9030707 Css NA 2.349 mg/L 3compartmentss NA 95% Rat Human -DTXSID9030707 Css NA 0.5851 mg/L PBTK NA 50% Rat Human -DTXSID9030707 Css NA 1.618 mg/L PBTK NA 95% Rat Human -DTXSID9031800 Clint NA 26.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9031800 Fup NA 0.0503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9031800 Vd NA 0.3964 L/kg 1compartment NA NA Human Human +DTXSID9030707 Vd NA 1.382 L/kg 1compartment NA NA Rat Human +DTXSID9030707 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9030707 TK.Half.Life NA 12.36 hours 1compartment NA NA Rat Human +DTXSID9030707 Css NA 0.03933 mg/L 3compartmentss NA 50% Rat Human +DTXSID9030707 Css NA 0.2513 mg/L 3compartmentss NA 95% Rat Human +DTXSID9030707 Css NA 0.03124 mg/L PBTK NA 50% Rat Human +DTXSID9030707 Css NA 0.1722 mg/L PBTK NA 95% Rat Human +DTXSID90311733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90311733 Fup 0.0134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90311733 Vd NA 2.201 L/kg 1compartment NA NA Human Human +DTXSID90311733 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID90311733 TK.Half.Life NA 30.41 hours 1compartment NA NA Human Human +DTXSID90311733 Css NA 2.058 mg/L 3compartmentss NA 50% Human Human +DTXSID90311733 Css NA 16.42 mg/L 3compartmentss NA 95% Human Human +DTXSID90311733 Css NA 1.329 mg/L PBTK NA 50% Human Human +DTXSID90311733 Css NA 10.17 mg/L PBTK NA 95% Human Human +DTXSID90311733 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90311733 Fup 0.0134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90311733 Vd NA 1.636 L/kg 1compartment NA NA Rat Human +DTXSID90311733 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID90311733 TK.Half.Life NA 8.873 hours 1compartment NA NA Rat Human +DTXSID90311733 Css NA 0.2652 mg/L 3compartmentss NA 50% Rat Human +DTXSID90311733 Css NA 1.691 mg/L 3compartmentss NA 95% Rat Human +DTXSID90311733 Css NA 0.1677 mg/L PBTK NA 50% Rat Human +DTXSID90311733 Css NA 1.032 mg/L PBTK NA 95% Rat Human +DTXSID9031800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9031800 Fup 0.0733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9031800 Vd NA 0.4656 L/kg 1compartment NA NA Human Human DTXSID9031800 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9031800 TK.Half.Life NA 1.445 hours 1compartment NA NA Human Human -DTXSID9031800 Css NA 0.5094 mg/L 3compartmentss NA 50% Human Human -DTXSID9031800 Css NA 4.257 mg/L 3compartmentss NA 95% Human Human -DTXSID9031800 Css NA 0.3079 mg/L PBTK NA 50% Human Human -DTXSID9031800 Css NA 2.532 mg/L PBTK NA 95% Human Human -DTXSID9031800 Clint NA 26.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9031800 Fup NA 0.0503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9031800 Vd NA 0.341 L/kg 1compartment NA NA Rat Human +DTXSID9031800 TK.Half.Life NA 3.914 hours 1compartment NA NA Human Human +DTXSID9031800 Css NA 1.267 mg/L 3compartmentss NA 50% Human Human +DTXSID9031800 Css NA 8.843 mg/L 3compartmentss NA 95% Human Human +DTXSID9031800 Css NA 0.7823 mg/L PBTK NA 50% Human Human +DTXSID9031800 Css NA 5.305 mg/L PBTK NA 95% Human Human +DTXSID9031800 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9031800 Fup 0.0733 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9031800 Vd NA 0.4 L/kg 1compartment NA NA Rat Human DTXSID9031800 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9031800 TK.Half.Life NA 0.7651 hours 1compartment NA NA Rat Human -DTXSID9031800 Css NA 0.2872 mg/L 3compartmentss NA 50% Rat Human -DTXSID9031800 Css NA 1.934 mg/L 3compartmentss NA 95% Rat Human -DTXSID9031800 Css NA 0.1623 mg/L PBTK NA 50% Rat Human -DTXSID9031800 Css NA 1.068 mg/L PBTK NA 95% Rat Human +DTXSID9031800 TK.Half.Life NA 2.052 hours 1compartment NA NA Rat Human +DTXSID9031800 Css NA 0.1581 mg/L 3compartmentss NA 50% Rat Human +DTXSID9031800 Css NA 0.8144 mg/L 3compartmentss NA 95% Rat Human +DTXSID9031800 Css NA 0.09444 mg/L PBTK NA 50% Rat Human +DTXSID9031800 Css NA 0.4664 mg/L PBTK NA 95% Rat Human DTXSID9032113 Clint 5.278 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9032113 Fup 0.06601 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9032113 Vd NA 2.545 L/kg 1compartment NA NA Human Human DTXSID9032113 Days.Css NA 7 Days PBTK NA NA Human Human DTXSID9032113 TK.Half.Life NA 54.84 hours 1compartment NA NA Human Human -DTXSID9032113 Css NA 2.968 mg/L 3compartmentss NA 50% Human Human -DTXSID9032113 Css NA 16.96 mg/L 3compartmentss NA 95% Human Human -DTXSID9032113 Css NA 2.023 mg/L PBTK NA 50% Human Human -DTXSID9032113 Css NA 10.88 mg/L PBTK NA 95% Human Human +DTXSID9032113 Css NA 2.917 mg/L 3compartmentss NA 50% Human Human +DTXSID9032113 Css NA 16.69 mg/L 3compartmentss NA 95% Human Human +DTXSID9032113 Css NA 1.975 mg/L PBTK NA 50% Human Human +DTXSID9032113 Css NA 10.67 mg/L PBTK NA 95% Human Human DTXSID9032113 Clint 5.278 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9032113 Fup 0.06601 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9032113 Vd NA 1.91 L/kg 1compartment NA NA Rat Human DTXSID9032113 Days.Css NA 4 Days PBTK NA NA Rat Human DTXSID9032113 TK.Half.Life NA 12.63 hours 1compartment NA NA Rat Human -DTXSID9032113 Css NA 1.583 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032113 Css NA 6.284 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032113 Css NA 1.02 mg/L PBTK NA 50% Rat Human -DTXSID9032113 Css NA 3.881 mg/L PBTK NA 95% Rat Human +DTXSID9032113 Css NA 0.3544 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032113 Css NA 1.465 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032113 Css NA 0.237 mg/L PBTK NA 50% Rat Human +DTXSID9032113 Css NA 0.9455 mg/L PBTK NA 95% Rat Human DTXSID9032327 Clint 21.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9032327 Fup 0.1971 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9032327 Vd NA 0.5897 L/kg 1compartment NA NA Human Human DTXSID9032327 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9032327 TK.Half.Life NA 0.9912 hours 1compartment NA NA Human Human -DTXSID9032327 Css NA 0.1187 mg/L 3compartmentss NA 50% Human Human -DTXSID9032327 Css NA 0.7933 mg/L 3compartmentss NA 95% Human Human -DTXSID9032327 Css NA 0.07947 mg/L PBTK NA 50% Human Human -DTXSID9032327 Css NA 0.505 mg/L PBTK NA 95% Human Human +DTXSID9032327 Css NA 0.1116 mg/L 3compartmentss NA 50% Human Human +DTXSID9032327 Css NA 0.8132 mg/L 3compartmentss NA 95% Human Human +DTXSID9032327 Css NA 0.07478 mg/L PBTK NA 50% Human Human +DTXSID9032327 Css NA 0.5117 mg/L PBTK NA 95% Human Human DTXSID9032327 Clint 21.66 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9032327 Fup 0.1971 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9032327 Vd NA 0.5167 L/kg 1compartment NA NA Rat Human DTXSID9032327 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9032327 TK.Half.Life NA 0.4761 hours 1compartment NA NA Rat Human -DTXSID9032327 Css NA 0.06493 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032327 Css NA 0.3224 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032327 Css NA 0.04108 mg/L PBTK NA 50% Rat Human -DTXSID9032327 Css NA 0.1953 mg/L PBTK NA 95% Rat Human +DTXSID9032327 Css NA 0.01427 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032327 Css NA 0.07638 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032327 Css NA 0.009398 mg/L PBTK NA 50% Rat Human +DTXSID9032327 Css NA 0.04759 mg/L PBTK NA 95% Rat Human DTXSID9032329 Clint 250.3 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9032329 Fup 0.006078 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9032329 Vd NA 1.763 L/kg 1compartment NA NA Human Human DTXSID9032329 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9032329 TK.Half.Life NA 4.533 hours 1compartment NA NA Human Human -DTXSID9032329 Css NA 0.2992 mg/L 3compartmentss NA 50% Human Human -DTXSID9032329 Css NA 2.694 mg/L 3compartmentss NA 95% Human Human -DTXSID9032329 Css NA 0.188 mg/L PBTK NA 50% Human Human -DTXSID9032329 Css NA 1.608 mg/L PBTK NA 95% Human Human +DTXSID9032329 Css NA 0.2785 mg/L 3compartmentss NA 50% Human Human +DTXSID9032329 Css NA 2.411 mg/L 3compartmentss NA 95% Human Human +DTXSID9032329 Css NA 0.1811 mg/L PBTK NA 50% Human Human +DTXSID9032329 Css NA 1.568 mg/L PBTK NA 95% Human Human DTXSID9032329 Clint 37.52 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID9032329 Fup 0.008183 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat -DTXSID9032329 Vd NA 1.453 L/kg 1compartment NA NA Rat Rat +DTXSID9032329 Vd 0.83 1.454 L/kg 1compartment Wambaugh et al. (2018) NA Rat Rat DTXSID9032329 Days.Css NA 1 Days PBTK NA NA Rat Rat -DTXSID9032329 TK.Half.Life NA 6.762 hours 1compartment NA NA Rat Rat -DTXSID9032329 Css NA 0.9506 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9032329 Css NA 6.706 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9032329 Css NA 0.5525 mg/L PBTK NA 50% Rat Rat -DTXSID9032329 Css NA 3.773 mg/L PBTK NA 95% Rat Rat -DTXSID9032375 Clint NA 0.1784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032375 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032375 Vd NA 0.7368 L/kg 1compartment NA NA Human Human -DTXSID9032375 Days.Css NA 35 Days PBTK NA NA Human Human -DTXSID9032375 TK.Half.Life NA 155.9 hours 1compartment NA NA Human Human -DTXSID9032375 Css NA 34.52 mg/L 3compartmentss NA 50% Human Human -DTXSID9032375 Css NA 205.7 mg/L 3compartmentss NA 95% Human Human -DTXSID9032375 Css NA 20.91 mg/L PBTK NA 50% Human Human -DTXSID9032375 Css NA 120.2 mg/L PBTK NA 95% Human Human -DTXSID9032375 Clint NA 0.1784 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032375 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032375 Vd NA 0.5603 L/kg 1compartment NA NA Rat Human -DTXSID9032375 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID9032375 TK.Half.Life NA 43.68 hours 1compartment NA NA Rat Human -DTXSID9032375 Css NA 11.49 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032375 Css NA 61.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032375 Css NA 6.49 mg/L PBTK NA 50% Rat Human -DTXSID9032375 Css NA 33.52 mg/L PBTK NA 95% Rat Human +DTXSID9032329 TK.Half.Life 0.098 6.762 hours 1compartment Wambaugh et al. (2018) NA Rat Rat +DTXSID9032329 Css 0.0071 0.1893 mg/L 3compartmentss Wambaugh et al. (2018) 50% Rat Rat +DTXSID9032329 Css 0.0071 1.305 mg/L 3compartmentss Wambaugh et al. (2018) 95% Rat Rat +DTXSID9032329 Css 0.0071 0.1275 mg/L PBTK Wambaugh et al. (2018) 50% Rat Rat +DTXSID9032329 Css 0.0071 0.8787 mg/L PBTK Wambaugh et al. (2018) 95% Rat Rat +DTXSID9032375 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032375 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032375 Vd NA 0.2854 L/kg 1compartment NA NA Human Human +DTXSID9032375 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9032375 TK.Half.Life NA 1.154 hours 1compartment NA NA Human Human +DTXSID9032375 Css NA 0.4388 mg/L 3compartmentss NA 50% Human Human +DTXSID9032375 Css NA 2.529 mg/L 3compartmentss NA 95% Human Human +DTXSID9032375 Css NA 0.2764 mg/L PBTK NA 50% Human Human +DTXSID9032375 Css NA 1.535 mg/L PBTK NA 95% Human Human +DTXSID9032375 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032375 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032375 Vd NA 0.2862 L/kg 1compartment NA NA Rat Human +DTXSID9032375 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9032375 TK.Half.Life NA 0.6836 hours 1compartment NA NA Rat Human +DTXSID9032375 Css NA 0.05292 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032375 Css NA 0.2186 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032375 Css NA 0.03244 mg/L PBTK NA 50% Rat Human +DTXSID9032375 Css NA 0.1271 mg/L PBTK NA 95% Rat Human DTXSID9032379 Clint 13.25 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID9032379 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032379 Vd NA 2.821 L/kg 1compartment NA NA Human Human -DTXSID9032379 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID9032379 TK.Half.Life NA 84.21 hours 1compartment NA NA Human Human -DTXSID9032379 Css NA 4.685 mg/L 3compartmentss NA 50% Human Human -DTXSID9032379 Css NA 30.38 mg/L 3compartmentss NA 95% Human Human -DTXSID9032379 Css NA 2.765 mg/L PBTK NA 50% Human Human -DTXSID9032379 Css NA 17.98 mg/L PBTK NA 95% Human Human +DTXSID9032379 Fup 0.00783 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032379 Vd NA 2.632 L/kg 1compartment NA NA Human Human +DTXSID9032379 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID9032379 TK.Half.Life NA 87.08 hours 1compartment NA NA Human Human +DTXSID9032379 Css NA 4.809 mg/L 3compartmentss NA 50% Human Human +DTXSID9032379 Css NA 33.93 mg/L 3compartmentss NA 95% Human Human +DTXSID9032379 Css NA 3.095 mg/L PBTK NA 50% Human Human +DTXSID9032379 Css NA 21.84 mg/L PBTK NA 95% Human Human DTXSID9032379 Clint 17.51 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID9032379 Fup 0.002593 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID9032379 Vd NA 1.509 L/kg 1compartment NA NA Rat Rat DTXSID9032379 Days.Css NA 6 Days PBTK NA NA Rat Rat DTXSID9032379 TK.Half.Life NA 23.67 hours 1compartment NA NA Rat Rat -DTXSID9032379 Css NA 3.52 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9032379 Css NA 20.97 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9032379 Css NA 2.025 mg/L PBTK NA 50% Rat Rat -DTXSID9032379 Css NA 11.97 mg/L PBTK NA 95% Rat Rat +DTXSID9032379 Css NA 0.7092 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9032379 Css NA 4.209 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9032379 Css NA 0.4726 mg/L PBTK NA 50% Rat Rat +DTXSID9032379 Css NA 2.806 mg/L PBTK NA 95% Rat Rat DTXSID9032406 Clint NA 0.02705 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9032406 Fup NA 0.6618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032406 Vd NA 0.4419 L/kg 1compartment NA NA Human Human +DTXSID9032406 Vd NA 0.4194 L/kg 1compartment NA NA Human Human DTXSID9032406 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9032406 TK.Half.Life NA 4.068 hours 1compartment NA NA Human Human -DTXSID9032406 Css NA 1.165 mg/L 3compartmentss NA 50% Human Human -DTXSID9032406 Css NA 7.005 mg/L 3compartmentss NA 95% Human Human -DTXSID9032406 Css NA 0.8592 mg/L PBTK NA 50% Human Human -DTXSID9032406 Css NA 4.352 mg/L PBTK NA 95% Human Human +DTXSID9032406 TK.Half.Life NA 3.66 hours 1compartment NA NA Human Human +DTXSID9032406 Css NA 0.927 mg/L 3compartmentss NA 50% Human Human +DTXSID9032406 Css NA 5.609 mg/L 3compartmentss NA 95% Human Human +DTXSID9032406 Css NA 0.6807 mg/L PBTK NA 50% Human Human +DTXSID9032406 Css NA 3.483 mg/L PBTK NA 95% Human Human DTXSID9032406 Clint NA 0.02705 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9032406 Fup NA 0.6618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032406 Vd NA 0.4669 L/kg 1compartment NA NA Rat Human +DTXSID9032406 Vd NA 0.4483 L/kg 1compartment NA NA Rat Human DTXSID9032406 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9032406 TK.Half.Life NA 1.51 hours 1compartment NA NA Rat Human -DTXSID9032406 Css NA 0.3129 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032406 Css NA 1.931 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032406 Css NA 0.2215 mg/L PBTK NA 50% Rat Human -DTXSID9032406 Css NA 1.107 mg/L PBTK NA 95% Rat Human -DTXSID9032531 Clint NA 9.241 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032531 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032531 Vd NA 1.707 L/kg 1compartment NA NA Human Human -DTXSID9032531 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9032531 TK.Half.Life NA 18.64 hours 1compartment NA NA Human Human -DTXSID9032531 Css NA 1.653 mg/L 3compartmentss NA 50% Human Human -DTXSID9032531 Css NA 10.82 mg/L 3compartmentss NA 95% Human Human -DTXSID9032531 Css NA 1.07 mg/L PBTK NA 50% Human Human -DTXSID9032531 Css NA 6.744 mg/L PBTK NA 95% Human Human -DTXSID9032531 Clint NA 9.241 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032531 Fup NA 0.0458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032531 Vd NA 1.279 L/kg 1compartment NA NA Rat Human +DTXSID9032406 TK.Half.Life NA 1.411 hours 1compartment NA NA Rat Human +DTXSID9032406 Css NA 0.01909 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032406 Css NA 0.1514 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032406 Css NA 0.01342 mg/L PBTK NA 50% Rat Human +DTXSID9032406 Css NA 0.09222 mg/L PBTK NA 95% Rat Human +DTXSID9032531 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032531 Fup 0.0931 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032531 Vd NA 2.186 L/kg 1compartment NA NA Human Human +DTXSID9032531 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9032531 TK.Half.Life NA 8.289 hours 1compartment NA NA Human Human +DTXSID9032531 Css NA 0.4236 mg/L 3compartmentss NA 50% Human Human +DTXSID9032531 Css NA 3.075 mg/L 3compartmentss NA 95% Human Human +DTXSID9032531 Css NA 0.2874 mg/L PBTK NA 50% Human Human +DTXSID9032531 Css NA 1.97 mg/L PBTK NA 95% Human Human +DTXSID9032531 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032531 Fup 0.0931 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032531 Vd NA 1.651 L/kg 1compartment NA NA Rat Human DTXSID9032531 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9032531 TK.Half.Life NA 6.658 hours 1compartment NA NA Rat Human -DTXSID9032531 Css NA 0.9112 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032531 Css NA 4.424 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032531 Css NA 0.5536 mg/L PBTK NA 50% Rat Human -DTXSID9032531 Css NA 2.581 mg/L PBTK NA 95% Rat Human -DTXSID9032533 Clint NA 9.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032533 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032533 Vd NA 2.665 L/kg 1compartment NA NA Human Human -DTXSID9032533 Days.Css NA 23 Days PBTK NA NA Human Human -DTXSID9032533 TK.Half.Life NA 128.4 hours 1compartment NA NA Human Human -DTXSID9032533 Css NA 7.017 mg/L 3compartmentss NA 50% Human Human -DTXSID9032533 Css NA 46.25 mg/L 3compartmentss NA 95% Human Human -DTXSID9032533 Css NA 4.677 mg/L PBTK NA 50% Human Human -DTXSID9032533 Css NA 29.57 mg/L PBTK NA 95% Human Human -DTXSID9032533 Clint NA 9.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032533 Fup NA 0.0071 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032533 Vd NA 1.988 L/kg 1compartment NA NA Rat Human -DTXSID9032533 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID9032533 TK.Half.Life NA 27.29 hours 1compartment NA NA Rat Human -DTXSID9032533 Css NA 3.922 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032533 Css NA 21.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032533 Css NA 2.471 mg/L PBTK NA 50% Rat Human -DTXSID9032533 Css NA 13.29 mg/L PBTK NA 95% Rat Human +DTXSID9032531 TK.Half.Life NA 2.548 hours 1compartment NA NA Rat Human +DTXSID9032531 Css NA 0.05492 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032531 Css NA 0.313 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032531 Css NA 0.03673 mg/L PBTK NA 50% Rat Human +DTXSID9032531 Css NA 0.1995 mg/L PBTK NA 95% Rat Human +DTXSID9032533 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032533 Fup 0.0184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032533 Vd NA 2.935 L/kg 1compartment NA NA Human Human +DTXSID9032533 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID9032533 TK.Half.Life NA 55.14 hours 1compartment NA NA Human Human +DTXSID9032533 Css NA 2.334 mg/L 3compartmentss NA 50% Human Human +DTXSID9032533 Css NA 16.14 mg/L 3compartmentss NA 95% Human Human +DTXSID9032533 Css NA 1.602 mg/L PBTK NA 50% Human Human +DTXSID9032533 Css NA 10.68 mg/L PBTK NA 95% Human Human +DTXSID9032533 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032533 Fup 0.0184 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032533 Vd NA 2.197 L/kg 1compartment NA NA Rat Human +DTXSID9032533 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID9032533 TK.Half.Life NA 9.441 hours 1compartment NA NA Rat Human +DTXSID9032533 Css NA 0.3087 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032533 Css NA 1.686 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032533 Css NA 0.2073 mg/L PBTK NA 50% Rat Human +DTXSID9032533 Css NA 1.115 mg/L PBTK NA 95% Rat Human DTXSID9032535 Clint 3.82 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9032535 Fup 0.137 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9032535 Vd NA 0.354 L/kg 1compartment NA NA Human Human DTXSID9032535 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9032535 TK.Half.Life NA 2.501 hours 1compartment NA NA Human Human -DTXSID9032535 Css NA 0.8358 mg/L 3compartmentss NA 50% Human Human -DTXSID9032535 Css NA 3.723 mg/L 3compartmentss NA 95% Human Human -DTXSID9032535 Css NA 0.5429 mg/L PBTK NA 50% Human Human -DTXSID9032535 Css NA 2.346 mg/L PBTK NA 95% Human Human +DTXSID9032535 Css NA 0.8162 mg/L 3compartmentss NA 50% Human Human +DTXSID9032535 Css NA 3.662 mg/L 3compartmentss NA 95% Human Human +DTXSID9032535 Css NA 0.5313 mg/L PBTK NA 50% Human Human +DTXSID9032535 Css NA 2.298 mg/L PBTK NA 95% Human Human DTXSID9032535 Clint 3.82 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9032535 Fup 0.137 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9032535 Vd NA 0.3521 L/kg 1compartment NA NA Rat Human DTXSID9032535 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9032535 TK.Half.Life NA 1.463 hours 1compartment NA NA Rat Human -DTXSID9032535 Css NA 0.4125 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032535 Css NA 1.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032535 Css NA 0.2525 mg/L PBTK NA 50% Rat Human -DTXSID9032535 Css NA 0.7837 mg/L PBTK NA 95% Rat Human -DTXSID9032537 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9032537 Fup NA 0.2306 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032537 Vd NA 4.579 L/kg 1compartment NA NA Human Human -DTXSID9032537 Days.Css NA 236 Days PBTK NA NA Human Human -DTXSID9032537 TK.Half.Life NA 944.1 hours 1compartment NA NA Human Human -DTXSID9032537 Css NA 15.8 mg/L 3compartmentss NA 50% Human Human -DTXSID9032537 Css NA 51.61 mg/L 3compartmentss NA 95% Human Human -DTXSID9032537 Css NA 16.54 mg/L PBTK NA 50% Human Human -DTXSID9032537 Css NA 43.56 mg/L PBTK NA 95% Human Human -DTXSID9032537 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID9032537 Fup NA 0.2306 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032537 Vd NA 4.03 L/kg 1compartment NA NA Rat Human -DTXSID9032537 Days.Css NA 70 Days PBTK NA NA Rat Human -DTXSID9032537 TK.Half.Life NA 96.82 hours 1compartment NA NA Rat Human -DTXSID9032537 Css NA 4.123 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032537 Css NA 10.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032537 Css NA 4.288 mg/L PBTK NA 50% Rat Human -DTXSID9032537 Css NA 8.624 mg/L PBTK NA 95% Rat Human +DTXSID9032535 Css NA 0.09364 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032535 Css NA 0.2985 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032535 Css NA 0.05923 mg/L PBTK NA 50% Rat Human +DTXSID9032535 Css NA 0.1812 mg/L PBTK NA 95% Rat Human DTXSID9032581 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9032581 Fup 0.01031 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9032581 Vd NA 1.398 L/kg 1compartment NA NA Human Human -DTXSID9032581 Days.Css NA 319 Days PBTK NA NA Human Human +DTXSID9032581 Days.Css NA 318 Days PBTK NA NA Human Human DTXSID9032581 TK.Half.Life NA 1211 hours 1compartment NA NA Human Human -DTXSID9032581 Css NA 132 mg/L 3compartmentss NA 50% Human Human -DTXSID9032581 Css NA 707.2 mg/L 3compartmentss NA 95% Human Human -DTXSID9032581 Css NA 85.66 mg/L PBTK NA 50% Human Human -DTXSID9032581 Css NA 415.5 mg/L PBTK NA 95% Human Human +DTXSID9032581 Css NA 121.8 mg/L 3compartmentss NA 50% Human Human +DTXSID9032581 Css NA 629.8 mg/L 3compartmentss NA 95% Human Human +DTXSID9032581 Css NA 81.84 mg/L PBTK NA 50% Human Human +DTXSID9032581 Css NA 423.1 mg/L PBTK NA 95% Human Human DTXSID9032581 Clint 41.26 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID9032581 Fup 0.05388 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID9032581 Vd NA 1.831 L/kg 1compartment NA NA Rat Rat DTXSID9032581 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9032581 TK.Half.Life NA 2.537 hours 1compartment NA NA Rat Rat -DTXSID9032581 Css NA 0.2745 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9032581 Css NA 1.585 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9032581 Css NA 0.1574 mg/L PBTK NA 50% Rat Rat -DTXSID9032581 Css NA 0.8927 mg/L PBTK NA 95% Rat Rat -DTXSID9032589 Clint NA 17.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032589 Fup NA 0.0013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032589 Vd NA 0.7942 L/kg 1compartment NA NA Human Human -DTXSID9032589 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID9032589 TK.Half.Life NA 87.78 hours 1compartment NA NA Human Human -DTXSID9032589 Css NA 20.94 mg/L 3compartmentss NA 50% Human Human -DTXSID9032589 Css NA 168.1 mg/L 3compartmentss NA 95% Human Human -DTXSID9032589 Css NA 12.51 mg/L PBTK NA 50% Human Human -DTXSID9032589 Css NA 97.65 mg/L PBTK NA 95% Human Human -DTXSID9032589 Clint NA 17.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032589 Fup NA 0.0013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032589 Vd NA 0.5852 L/kg 1compartment NA NA Rat Human -DTXSID9032589 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID9032589 TK.Half.Life NA 43.27 hours 1compartment NA NA Rat Human -DTXSID9032589 Css NA 11.89 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032589 Css NA 76.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032589 Css NA 6.609 mg/L PBTK NA 50% Rat Human -DTXSID9032589 Css NA 41.81 mg/L PBTK NA 95% Rat Human -DTXSID9032610 Clint NA 234.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032610 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032610 Vd NA 17.25 L/kg 1compartment NA NA Human Human -DTXSID9032610 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID9032610 TK.Half.Life NA 52.12 hours 1compartment NA NA Human Human -DTXSID9032610 Css NA 0.122 mg/L 3compartmentss NA 50% Human Human -DTXSID9032610 Css NA 0.7466 mg/L 3compartmentss NA 95% Human Human -DTXSID9032610 Css NA 0.2242 mg/L PBTK NA 50% Human Human -DTXSID9032610 Css NA 1.319 mg/L PBTK NA 95% Human Human -DTXSID9032610 Clint NA 234.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032610 Fup NA 0.0136 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032610 Vd NA 13.92 L/kg 1compartment NA NA Rat Human -DTXSID9032610 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9032610 TK.Half.Life NA 8.346 hours 1compartment NA NA Rat Human -DTXSID9032610 Css NA 0.06501 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032610 Css NA 0.2702 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032610 Css NA 0.1229 mg/L PBTK NA 50% Rat Human -DTXSID9032610 Css NA 0.5191 mg/L PBTK NA 95% Rat Human -DTXSID9032614 Clint NA 30.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032614 Fup NA 0.0178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032614 Vd NA 2.822 L/kg 1compartment NA NA Human Human -DTXSID9032614 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9032614 TK.Half.Life NA 34.66 hours 1compartment NA NA Human Human -DTXSID9032614 Css NA 1.606 mg/L 3compartmentss NA 50% Human Human -DTXSID9032614 Css NA 11.18 mg/L 3compartmentss NA 95% Human Human -DTXSID9032614 Css NA 1.087 mg/L PBTK NA 50% Human Human -DTXSID9032614 Css NA 7.304 mg/L PBTK NA 95% Human Human -DTXSID9032614 Clint NA 30.09 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032614 Fup NA 0.0178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032614 Vd NA 2.11 L/kg 1compartment NA NA Rat Human -DTXSID9032614 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9032614 TK.Half.Life NA 6.749 hours 1compartment NA NA Rat Human -DTXSID9032614 Css NA 0.9034 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032614 Css NA 4.936 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032614 Css NA 0.5806 mg/L PBTK NA 50% Rat Human -DTXSID9032614 Css NA 3.121 mg/L PBTK NA 95% Rat Human -DTXSID9032878 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032878 Fup NA 0.9605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9032878 Vd NA 0.9248 L/kg 1compartment NA NA Human Human +DTXSID9032581 Css NA 0.05332 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9032581 Css NA 0.2983 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9032581 Css NA 0.0371 mg/L PBTK NA 50% Rat Rat +DTXSID9032581 Css NA 0.2076 mg/L PBTK NA 95% Rat Rat +DTXSID9032589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032589 Fup 0.00224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032589 Vd NA 0.722 L/kg 1compartment NA NA Human Human +DTXSID9032589 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID9032589 TK.Half.Life NA 39.32 hours 1compartment NA NA Human Human +DTXSID9032589 Css NA 8.63 mg/L 3compartmentss NA 50% Human Human +DTXSID9032589 Css NA 84.92 mg/L 3compartmentss NA 95% Human Human +DTXSID9032589 Css NA 5.131 mg/L PBTK NA 50% Human Human +DTXSID9032589 Css NA 49.83 mg/L PBTK NA 95% Human Human +DTXSID9032589 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032589 Fup 0.00224 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032589 Vd NA 0.5369 L/kg 1compartment NA NA Rat Human +DTXSID9032589 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9032589 TK.Half.Life NA 19.24 hours 1compartment NA NA Rat Human +DTXSID9032589 Css NA 0.4372 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032589 Css NA 4.642 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032589 Css NA 0.2487 mg/L PBTK NA 50% Rat Human +DTXSID9032589 Css NA 2.597 mg/L PBTK NA 95% Rat Human +DTXSID9032610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032610 Fup 0.00334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032610 Vd NA 16.87 L/kg 1compartment NA NA Human Human +DTXSID9032610 Days.Css NA 116 Days PBTK NA NA Human Human +DTXSID9032610 TK.Half.Life NA 516.9 hours 1compartment NA NA Human Human +DTXSID9032610 Css NA 1.363 mg/L 3compartmentss NA 50% Human Human +DTXSID9032610 Css NA 8.024 mg/L 3compartmentss NA 95% Human Human +DTXSID9032610 Css NA 2.468 mg/L PBTK NA 50% Human Human +DTXSID9032610 Css NA 13.97 mg/L PBTK NA 95% Human Human +DTXSID9032610 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032610 Fup 0.00334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032610 Vd NA 13.59 L/kg 1compartment NA NA Rat Human +DTXSID9032610 Days.Css NA 70 Days PBTK NA NA Rat Human +DTXSID9032610 TK.Half.Life NA 79.36 hours 1compartment NA NA Rat Human +DTXSID9032610 Css NA 0.168 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032610 Css NA 0.7832 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032610 Css NA 0.32 mg/L PBTK NA 50% Rat Human +DTXSID9032610 Css NA 1.583 mg/L PBTK NA 95% Rat Human +DTXSID9032878 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032878 Fup 0.728 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9032878 Vd NA 0.7674 L/kg 1compartment NA NA Human Human DTXSID9032878 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9032878 TK.Half.Life NA 6.273 hours 1compartment NA NA Human Human -DTXSID9032878 Css NA 0.8141 mg/L 3compartmentss NA 50% Human Human -DTXSID9032878 Css NA 2.949 mg/L 3compartmentss NA 95% Human Human -DTXSID9032878 Css NA 0.7091 mg/L PBTK NA 50% Human Human -DTXSID9032878 Css NA 2.121 mg/L PBTK NA 95% Human Human -DTXSID9032878 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032878 Fup NA 0.9605 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9032878 Vd NA 0.9365 L/kg 1compartment NA NA Rat Human +DTXSID9032878 TK.Half.Life NA 6.849 hours 1compartment NA NA Human Human +DTXSID9032878 Css NA 0.8912 mg/L 3compartmentss NA 50% Human Human +DTXSID9032878 Css NA 5.629 mg/L 3compartmentss NA 95% Human Human +DTXSID9032878 Css NA 0.7397 mg/L PBTK NA 50% Human Human +DTXSID9032878 Css NA 3.656 mg/L PBTK NA 95% Human Human +DTXSID9032878 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032878 Fup 0.728 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9032878 Vd NA 0.7789 L/kg 1compartment NA NA Rat Human DTXSID9032878 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9032878 TK.Half.Life NA 2.153 hours 1compartment NA NA Rat Human -DTXSID9032878 Css NA 0.21 mg/L 3compartmentss NA 50% Rat Human -DTXSID9032878 Css NA 0.6563 mg/L 3compartmentss NA 95% Rat Human -DTXSID9032878 Css NA 0.1794 mg/L PBTK NA 50% Rat Human -DTXSID9032878 Css NA 0.4387 mg/L PBTK NA 95% Rat Human -DTXSID9033008 Clint NA 1.076 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033008 Fup NA 0.0886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033008 Vd NA 0.9776 L/kg 1compartment NA NA Human Human -DTXSID9033008 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9033008 TK.Half.Life NA 27.6 hours 1compartment NA NA Human Human -DTXSID9033008 Css NA 4.328 mg/L 3compartmentss NA 50% Human Human -DTXSID9033008 Css NA 21.93 mg/L 3compartmentss NA 95% Human Human -DTXSID9033008 Css NA 2.768 mg/L PBTK NA 50% Human Human -DTXSID9033008 Css NA 13.08 mg/L PBTK NA 95% Human Human -DTXSID9033008 Clint NA 1.076 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033008 Fup NA 0.0886 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033008 Vd NA 0.7662 L/kg 1compartment NA NA Rat Human -DTXSID9033008 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9033008 TK.Half.Life NA 10.11 hours 1compartment NA NA Rat Human -DTXSID9033008 Css NA 1.84 mg/L 3compartmentss NA 50% Rat Human -DTXSID9033008 Css NA 7.591 mg/L 3compartmentss NA 95% Rat Human -DTXSID9033008 Css NA 1.115 mg/L PBTK NA 50% Rat Human -DTXSID9033008 Css NA 4.237 mg/L PBTK NA 95% Rat Human +DTXSID9032878 TK.Half.Life NA 2.362 hours 1compartment NA NA Rat Human +DTXSID9032878 Css NA 0.01698 mg/L 3compartmentss NA 50% Rat Human +DTXSID9032878 Css NA 0.1375 mg/L 3compartmentss NA 95% Rat Human +DTXSID9032878 Css NA 0.01342 mg/L PBTK NA 50% Rat Human +DTXSID9032878 Css NA 0.08807 mg/L PBTK NA 95% Rat Human +DTXSID9033008 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9033008 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9033008 Vd NA 1.068 L/kg 1compartment NA NA Human Human +DTXSID9033008 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9033008 TK.Half.Life NA 2.665 hours 1compartment NA NA Human Human +DTXSID9033008 Css NA 0.2577 mg/L 3compartmentss NA 50% Human Human +DTXSID9033008 Css NA 2.016 mg/L 3compartmentss NA 95% Human Human +DTXSID9033008 Css NA 0.168 mg/L PBTK NA 50% Human Human +DTXSID9033008 Css NA 1.267 mg/L PBTK NA 95% Human Human +DTXSID9033008 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9033008 Fup 0.109 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9033008 Vd NA 0.8396 L/kg 1compartment NA NA Rat Human +DTXSID9033008 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9033008 TK.Half.Life NA 1.148 hours 1compartment NA NA Rat Human +DTXSID9033008 Css NA 0.03356 mg/L 3compartmentss NA 50% Rat Human +DTXSID9033008 Css NA 0.2028 mg/L 3compartmentss NA 95% Rat Human +DTXSID9033008 Css NA 0.02142 mg/L PBTK NA 50% Rat Human +DTXSID9033008 Css NA 0.1241 mg/L PBTK NA 95% Rat Human DTXSID9033058 Clint NA 0.5851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9033058 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033058 Vd NA 0.8926 L/kg 1compartment NA NA Human Human +DTXSID9033058 Vd NA 0.8945 L/kg 1compartment NA NA Human Human DTXSID9033058 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9033058 TK.Half.Life NA 3.067 hours 1compartment NA NA Human Human -DTXSID9033058 Css NA 0.4042 mg/L 3compartmentss NA 50% Human Human -DTXSID9033058 Css NA 2.734 mg/L 3compartmentss NA 95% Human Human -DTXSID9033058 Css NA 0.3506 mg/L PBTK NA 50% Human Human -DTXSID9033058 Css NA 1.852 mg/L PBTK NA 95% Human Human +DTXSID9033058 TK.Half.Life NA 3.074 hours 1compartment NA NA Human Human +DTXSID9033058 Css NA 0.3395 mg/L 3compartmentss NA 50% Human Human +DTXSID9033058 Css NA 2.26 mg/L 3compartmentss NA 95% Human Human +DTXSID9033058 Css NA 0.2938 mg/L PBTK NA 50% Human Human +DTXSID9033058 Css NA 1.512 mg/L PBTK NA 95% Human Human DTXSID9033058 Clint NA 0.5851 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9033058 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033058 Vd NA 0.9139 L/kg 1compartment NA NA Rat Human +DTXSID9033058 Vd NA 0.9155 L/kg 1compartment NA NA Rat Human DTXSID9033058 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9033058 TK.Half.Life NA 1.395 hours 1compartment NA NA Rat Human -DTXSID9033058 Css NA 0.1379 mg/L 3compartmentss NA 50% Rat Human -DTXSID9033058 Css NA 0.9116 mg/L 3compartmentss NA 95% Rat Human -DTXSID9033058 Css NA 0.1183 mg/L PBTK NA 50% Rat Human -DTXSID9033058 Css NA 0.5522 mg/L PBTK NA 95% Rat Human -DTXSID9033187 Clint NA 12.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033187 Fup NA 0.0631 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033187 Vd NA 2.917 L/kg 1compartment NA NA Human Human +DTXSID9033058 TK.Half.Life NA 1.397 hours 1compartment NA NA Rat Human +DTXSID9033058 Css NA 0.008105 mg/L 3compartmentss NA 50% Rat Human +DTXSID9033058 Css NA 0.07473 mg/L 3compartmentss NA 95% Rat Human +DTXSID9033058 Css NA 0.006857 mg/L PBTK NA 50% Rat Human +DTXSID9033058 Css NA 0.04746 mg/L PBTK NA 95% Rat Human +DTXSID9033187 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9033187 Fup 0.081 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9033187 Vd NA 3.291 L/kg 1compartment NA NA Human Human DTXSID9033187 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9033187 TK.Half.Life NA 4.297 hours 1compartment NA NA Human Human -DTXSID9033187 Css NA 0.1086 mg/L 3compartmentss NA 50% Human Human -DTXSID9033187 Css NA 1.106 mg/L 3compartmentss NA 95% Human Human -DTXSID9033187 Css NA 0.101 mg/L PBTK NA 50% Human Human -DTXSID9033187 Css NA 0.8319 mg/L PBTK NA 95% Human Human -DTXSID9033187 Clint NA 12.24 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033187 Fup NA 0.0631 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033187 Vd NA 2.807 L/kg 1compartment NA NA Rat Human +DTXSID9033187 TK.Half.Life NA 6.809 hours 1compartment NA NA Human Human +DTXSID9033187 Css NA 0.1629 mg/L 3compartmentss NA 50% Human Human +DTXSID9033187 Css NA 1.545 mg/L 3compartmentss NA 95% Human Human +DTXSID9033187 Css NA 0.1626 mg/L PBTK NA 50% Human Human +DTXSID9033187 Css NA 1.251 mg/L PBTK NA 95% Human Human +DTXSID9033187 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9033187 Fup 0.081 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9033187 Vd NA 3.19 L/kg 1compartment NA NA Rat Human DTXSID9033187 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9033187 TK.Half.Life NA 2.288 hours 1compartment NA NA Rat Human -DTXSID9033187 Css NA 0.05975 mg/L 3compartmentss NA 50% Rat Human -DTXSID9033187 Css NA 0.4517 mg/L 3compartmentss NA 95% Rat Human -DTXSID9033187 Css NA 0.05402 mg/L PBTK NA 50% Rat Human -DTXSID9033187 Css NA 0.3328 mg/L PBTK NA 95% Rat Human -DTXSID9033264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033264 Fup NA 0.4009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033264 Vd NA 1.347 L/kg 1compartment NA NA Human Human -DTXSID9033264 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9033264 TK.Half.Life NA 25.66 hours 1compartment NA NA Human Human -DTXSID9033264 Css NA 1.987 mg/L 3compartmentss NA 50% Human Human -DTXSID9033264 Css NA 8.521 mg/L 3compartmentss NA 95% Human Human -DTXSID9033264 Css NA 1.589 mg/L PBTK NA 50% Human Human -DTXSID9033264 Css NA 5.584 mg/L PBTK NA 95% Human Human -DTXSID9033264 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033264 Fup NA 0.4009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033264 Vd NA 1.134 L/kg 1compartment NA NA Rat Human -DTXSID9033264 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9033264 TK.Half.Life NA 6.508 hours 1compartment NA NA Rat Human -DTXSID9033264 Css NA 0.5321 mg/L 3compartmentss NA 50% Rat Human -DTXSID9033264 Css NA 1.956 mg/L 3compartmentss NA 95% Rat Human -DTXSID9033264 Css NA 0.4101 mg/L PBTK NA 50% Rat Human -DTXSID9033264 Css NA 1.209 mg/L PBTK NA 95% Rat Human -DTXSID9033896 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033896 Fup NA 0.1145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033896 Vd NA 1.435 L/kg 1compartment NA NA Human Human -DTXSID9033896 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID9033896 TK.Half.Life NA 108.1 hours 1compartment NA NA Human Human -DTXSID9033896 Css NA 10.47 mg/L 3compartmentss NA 50% Human Human -DTXSID9033896 Css NA 44.57 mg/L 3compartmentss NA 95% Human Human -DTXSID9033896 Css NA 7.014 mg/L PBTK NA 50% Human Human -DTXSID9033896 Css NA 27.13 mg/L PBTK NA 95% Human Human -DTXSID9033896 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033896 Fup NA 0.1145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033896 Vd NA 1.107 L/kg 1compartment NA NA Rat Human -DTXSID9033896 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9033896 TK.Half.Life NA 23 hours 1compartment NA NA Rat Human -DTXSID9033896 Css NA 2.904 mg/L 3compartmentss NA 50% Rat Human -DTXSID9033896 Css NA 10.38 mg/L 3compartmentss NA 95% Rat Human -DTXSID9033896 Css NA 1.836 mg/L PBTK NA 50% Rat Human -DTXSID9033896 Css NA 5.902 mg/L PBTK NA 95% Rat Human +DTXSID9033187 TK.Half.Life NA 3.749 hours 1compartment NA NA Rat Human +DTXSID9033187 Css NA 0.0205 mg/L 3compartmentss NA 50% Rat Human +DTXSID9033187 Css NA 0.1542 mg/L 3compartmentss NA 95% Rat Human +DTXSID9033187 Css NA 0.02077 mg/L PBTK NA 50% Rat Human +DTXSID9033187 Css NA 0.1247 mg/L PBTK NA 95% Rat Human +DTXSID90334987 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90334987 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90334987 Vd NA 2.897 L/kg 1compartment NA NA Human Human +DTXSID90334987 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90334987 TK.Half.Life NA 10.13 hours 1compartment NA NA Human Human +DTXSID90334987 Css NA 0.3185 mg/L 3compartmentss NA 50% Human Human +DTXSID90334987 Css NA 1.97 mg/L 3compartmentss NA 95% Human Human +DTXSID90334987 Css NA 0.231 mg/L PBTK NA 50% Human Human +DTXSID90334987 Css NA 1.383 mg/L PBTK NA 95% Human Human +DTXSID90334987 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90334987 Fup 0.281 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90334987 Vd NA 2.197 L/kg 1compartment NA NA Rat Human +DTXSID90334987 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90334987 TK.Half.Life NA 2.162 hours 1compartment NA NA Rat Human +DTXSID90334987 Css NA 0.04021 mg/L 3compartmentss NA 50% Rat Human +DTXSID90334987 Css NA 0.201 mg/L 3compartmentss NA 95% Rat Human +DTXSID90334987 Css NA 0.02919 mg/L PBTK NA 50% Rat Human +DTXSID90334987 Css NA 0.1392 mg/L PBTK NA 95% Rat Human +DTXSID90338228 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90338228 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90338228 Vd NA 1.759 L/kg 1compartment NA NA Human Human +DTXSID90338228 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90338228 TK.Half.Life NA 2.056 hours 1compartment NA NA Human Human +DTXSID90338228 Css NA 0.0561 mg/L 3compartmentss NA 50% Human Human +DTXSID90338228 Css NA 0.4453 mg/L 3compartmentss NA 95% Human Human +DTXSID90338228 Css NA 0.04536 mg/L PBTK NA 50% Human Human +DTXSID90338228 Css NA 0.3246 mg/L PBTK NA 95% Human Human +DTXSID90338228 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90338228 Fup 0.424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90338228 Vd NA 1.43 L/kg 1compartment NA NA Rat Human +DTXSID90338228 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90338228 TK.Half.Life NA 0.7799 hours 1compartment NA NA Rat Human +DTXSID90338228 Css NA 0.006928 mg/L 3compartmentss NA 50% Rat Human +DTXSID90338228 Css NA 0.04092 mg/L 3compartmentss NA 95% Rat Human +DTXSID90338228 Css NA 0.005632 mg/L PBTK NA 50% Rat Human +DTXSID90338228 Css NA 0.02978 mg/L PBTK NA 95% Rat Human DTXSID9033923 Clint 5.32 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9033923 Fup 0.0499 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9033923 Vd NA 1.534 L/kg 1compartment NA NA Human Human DTXSID9033923 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID9033923 TK.Half.Life NA 24.05 hours 1compartment NA NA Human Human -DTXSID9033923 Css NA 2.018 mg/L 3compartmentss NA 50% Human Human -DTXSID9033923 Css NA 11.89 mg/L 3compartmentss NA 95% Human Human -DTXSID9033923 Css NA 1.32 mg/L PBTK NA 50% Human Human -DTXSID9033923 Css NA 7.417 mg/L PBTK NA 95% Human Human +DTXSID9033923 Css NA 1.977 mg/L 3compartmentss NA 50% Human Human +DTXSID9033923 Css NA 11.75 mg/L 3compartmentss NA 95% Human Human +DTXSID9033923 Css NA 1.291 mg/L PBTK NA 50% Human Human +DTXSID9033923 Css NA 7.302 mg/L PBTK NA 95% Human Human DTXSID9033923 Clint 5.32 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9033923 Fup 0.0499 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9033923 Vd NA 1.153 L/kg 1compartment NA NA Rat Human DTXSID9033923 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID9033923 TK.Half.Life NA 8.883 hours 1compartment NA NA Rat Human -DTXSID9033923 Css NA 1.068 mg/L 3compartmentss NA 50% Rat Human -DTXSID9033923 Css NA 4.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID9033923 Css NA 0.6566 mg/L PBTK NA 50% Rat Human -DTXSID9033923 Css NA 2.694 mg/L PBTK NA 95% Rat Human -DTXSID9033979 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033979 Fup NA 0.0991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9033979 Vd NA 0.2844 L/kg 1compartment NA NA Human Human -DTXSID9033979 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9033979 TK.Half.Life NA 18.6 hours 1compartment NA NA Human Human -DTXSID9033979 Css NA 10.25 mg/L 3compartmentss NA 50% Human Human -DTXSID9033979 Css NA 45.32 mg/L 3compartmentss NA 95% Human Human -DTXSID9033979 Css NA 6.329 mg/L PBTK NA 50% Human Human -DTXSID9033979 Css NA 26.65 mg/L PBTK NA 95% Human Human -DTXSID9033979 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033979 Fup NA 0.0991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9033979 Vd NA 0.2755 L/kg 1compartment NA NA Rat Human +DTXSID9033923 Css NA 0.2398 mg/L 3compartmentss NA 50% Rat Human +DTXSID9033923 Css NA 1.04 mg/L 3compartmentss NA 95% Rat Human +DTXSID9033923 Css NA 0.1525 mg/L PBTK NA 50% Rat Human +DTXSID9033923 Css NA 0.6277 mg/L PBTK NA 95% Rat Human +DTXSID9033979 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9033979 Fup 0.0885 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9033979 Vd NA 0.3088 L/kg 1compartment NA NA Human Human +DTXSID9033979 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9033979 TK.Half.Life NA 22.64 hours 1compartment NA NA Human Human +DTXSID9033979 Css NA 11.27 mg/L 3compartmentss NA 50% Human Human +DTXSID9033979 Css NA 51.21 mg/L 3compartmentss NA 95% Human Human +DTXSID9033979 Css NA 6.974 mg/L PBTK NA 50% Human Human +DTXSID9033979 Css NA 29.94 mg/L PBTK NA 95% Human Human +DTXSID9033979 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9033979 Fup 0.0885 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9033979 Vd NA 0.2925 L/kg 1compartment NA NA Rat Human DTXSID9033979 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9033979 TK.Half.Life NA 6.129 hours 1compartment NA NA Rat Human -DTXSID9033979 Css NA 2.884 mg/L 3compartmentss NA 50% Rat Human -DTXSID9033979 Css NA 11.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID9033979 Css NA 1.662 mg/L PBTK NA 50% Rat Human -DTXSID9033979 Css NA 6.164 mg/L PBTK NA 95% Rat Human +DTXSID9033979 TK.Half.Life NA 7.293 hours 1compartment NA NA Rat Human +DTXSID9033979 Css NA 0.744 mg/L 3compartmentss NA 50% Rat Human +DTXSID9033979 Css NA 2.78 mg/L 3compartmentss NA 95% Rat Human +DTXSID9033979 Css NA 0.4446 mg/L PBTK NA 50% Rat Human +DTXSID9033979 Css NA 1.585 mg/L PBTK NA 95% Rat Human DTXSID9034232 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9034232 Fup 0.02239 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID9034232 Vd NA 0.2203 L/kg 1compartment NA NA Human Human +DTXSID9034232 Vd NA 0.2206 L/kg 1compartment NA NA Human Human DTXSID9034232 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID9034232 TK.Half.Life NA 63.65 hours 1compartment NA NA Human Human -DTXSID9034232 Css NA 49.96 mg/L 3compartmentss NA 50% Human Human -DTXSID9034232 Css NA 306.5 mg/L 3compartmentss NA 95% Human Human -DTXSID9034232 Css NA 29.46 mg/L PBTK NA 50% Human Human -DTXSID9034232 Css NA 176.6 mg/L PBTK NA 95% Human Human +DTXSID9034232 TK.Half.Life NA 63.77 hours 1compartment NA NA Human Human +DTXSID9034232 Css NA 48.2 mg/L 3compartmentss NA 50% Human Human +DTXSID9034232 Css NA 297.8 mg/L 3compartmentss NA 95% Human Human +DTXSID9034232 Css NA 28.47 mg/L PBTK NA 50% Human Human +DTXSID9034232 Css NA 172.1 mg/L PBTK NA 95% Human Human DTXSID9034232 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9034232 Fup 0.02239 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID9034232 Vd NA 0.2154 L/kg 1compartment NA NA Rat Human +DTXSID9034232 Vd NA 0.2156 L/kg 1compartment NA NA Rat Human DTXSID9034232 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9034232 TK.Half.Life NA 21.21 hours 1compartment NA NA Rat Human -DTXSID9034232 Css NA 14.04 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034232 Css NA 75.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034232 Css NA 7.771 mg/L PBTK NA 50% Rat Human -DTXSID9034232 Css NA 40.94 mg/L PBTK NA 95% Rat Human -DTXSID9034282 Clint NA 3.705 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9034282 Fup NA 0.0738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9034282 Vd NA 0.3262 L/kg 1compartment NA NA Human Human -DTXSID9034282 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9034282 TK.Half.Life NA 4.227 hours 1compartment NA NA Human Human -DTXSID9034282 Css NA 2.08 mg/L 3compartmentss NA 50% Human Human -DTXSID9034282 Css NA 13.11 mg/L 3compartmentss NA 95% Human Human -DTXSID9034282 Css NA 1.3 mg/L PBTK NA 50% Human Human -DTXSID9034282 Css NA 7.816 mg/L PBTK NA 95% Human Human -DTXSID9034282 Clint NA 3.705 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9034282 Fup NA 0.0738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9034282 Vd NA 0.3212 L/kg 1compartment NA NA Rat Human +DTXSID9034232 TK.Half.Life NA 21.23 hours 1compartment NA NA Rat Human +DTXSID9034232 Css NA 3.141 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034232 Css NA 16.58 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034232 Css NA 1.8 mg/L PBTK NA 50% Rat Human +DTXSID9034232 Css NA 9.319 mg/L PBTK NA 95% Rat Human +DTXSID9034282 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9034282 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9034282 Vd NA 0.4007 L/kg 1compartment NA NA Human Human +DTXSID9034282 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9034282 TK.Half.Life NA 22.35 hours 1compartment NA NA Human Human +DTXSID9034282 Css NA 7.944 mg/L 3compartmentss NA 50% Human Human +DTXSID9034282 Css NA 38.19 mg/L 3compartmentss NA 95% Human Human +DTXSID9034282 Css NA 5.145 mg/L PBTK NA 50% Human Human +DTXSID9034282 Css NA 22.85 mg/L PBTK NA 95% Human Human +DTXSID9034282 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9034282 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9034282 Vd NA 0.3957 L/kg 1compartment NA NA Rat Human DTXSID9034282 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9034282 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human -DTXSID9034282 Css NA 1.06 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034282 Css NA 4.831 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034282 Css NA 0.6176 mg/L PBTK NA 50% Rat Human -DTXSID9034282 Css NA 2.681 mg/L PBTK NA 95% Rat Human -DTXSID9034286 Clint NA 1.568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9034286 Fup NA 0.9083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9034286 Vd NA 0.8798 L/kg 1compartment NA NA Human Human -DTXSID9034286 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9034286 TK.Half.Life NA 2.013 hours 1compartment NA NA Human Human -DTXSID9034286 Css NA 0.2592 mg/L 3compartmentss NA 50% Human Human -DTXSID9034286 Css NA 1.631 mg/L 3compartmentss NA 95% Human Human -DTXSID9034286 Css NA 0.2192 mg/L PBTK NA 50% Human Human -DTXSID9034286 Css NA 1.103 mg/L PBTK NA 95% Human Human -DTXSID9034286 Clint NA 1.568 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9034286 Fup NA 0.9083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9034286 Vd NA 0.8939 L/kg 1compartment NA NA Rat Human +DTXSID9034282 TK.Half.Life NA 7.52 hours 1compartment NA NA Rat Human +DTXSID9034282 Css NA 0.515 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034282 Css NA 2.116 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034282 Css NA 0.3248 mg/L PBTK NA 50% Rat Human +DTXSID9034282 Css NA 1.223 mg/L PBTK NA 95% Rat Human +DTXSID9034286 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9034286 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9034286 Vd NA 0.6432 L/kg 1compartment NA NA Human Human +DTXSID9034286 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9034286 TK.Half.Life NA 9.732 hours 1compartment NA NA Human Human +DTXSID9034286 Css NA 1.614 mg/L 3compartmentss NA 50% Human Human +DTXSID9034286 Css NA 7.269 mg/L 3compartmentss NA 95% Human Human +DTXSID9034286 Css NA 1.224 mg/L PBTK NA 50% Human Human +DTXSID9034286 Css NA 4.715 mg/L PBTK NA 95% Human Human +DTXSID9034286 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9034286 Fup 0.431 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9034286 Vd NA 0.6335 L/kg 1compartment NA NA Rat Human DTXSID9034286 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9034286 TK.Half.Life NA 1.031 hours 1compartment NA NA Rat Human +DTXSID9034286 TK.Half.Life NA 3.248 hours 1compartment NA NA Rat Human DTXSID9034286 Css NA 0.1022 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034286 Css NA 0.6216 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034286 Css NA 0.08589 mg/L PBTK NA 50% Rat Human -DTXSID9034286 Css NA 0.3832 mg/L PBTK NA 95% Rat Human -DTXSID9034317 Clint NA 116.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9034317 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9034317 Vd NA 1.277 L/kg 1compartment NA NA Human Human -DTXSID9034317 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9034317 TK.Half.Life NA 0.8879 hours 1compartment NA NA Human Human -DTXSID9034317 Css NA 0.007749 mg/L 3compartmentss NA 50% Human Human -DTXSID9034317 Css NA 0.07535 mg/L 3compartmentss NA 95% Human Human -DTXSID9034317 Css NA 0.006376 mg/L PBTK NA 50% Human Human -DTXSID9034317 Css NA 0.05475 mg/L PBTK NA 95% Human Human -DTXSID9034317 Clint NA 116.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9034317 Fup NA 0.526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9034317 Vd NA 1.117 L/kg 1compartment NA NA Rat Human -DTXSID9034317 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9034317 TK.Half.Life NA 0.3474 hours 1compartment NA NA Rat Human -DTXSID9034317 Css NA 0.004074 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034317 Css NA 0.03656 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034317 Css NA 0.003304 mg/L PBTK NA 50% Rat Human -DTXSID9034317 Css NA 0.02472 mg/L PBTK NA 95% Rat Human +DTXSID9034286 Css NA 0.4035 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034286 Css NA 0.07666 mg/L PBTK NA 50% Rat Human +DTXSID9034286 Css NA 0.2494 mg/L PBTK NA 95% Rat Human DTXSID9034361 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9034361 Fup 0.488 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9034361 Vd NA 3.14 L/kg 1compartment NA NA Human Human -DTXSID9034361 Days.Css NA 651 Days PBTK NA NA Human Human -DTXSID9034361 TK.Half.Life NA 3644 hours 1compartment NA NA Human Human -DTXSID9034361 Css NA 128.2 mg/L 3compartmentss NA 50% Human Human -DTXSID9034361 Css NA 358.5 mg/L 3compartmentss NA 95% Human Human -DTXSID9034361 Css NA 91.16 mg/L PBTK NA 50% Human Human -DTXSID9034361 Css NA 235 mg/L PBTK NA 95% Human Human +DTXSID9034361 Vd NA 0.8137 L/kg 1compartment NA NA Human Human +DTXSID9034361 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9034361 TK.Half.Life NA 10.95 hours 1compartment NA NA Human Human +DTXSID9034361 Css NA 1.278 mg/L 3compartmentss NA 50% Human Human +DTXSID9034361 Css NA 3.79 mg/L 3compartmentss NA 95% Human Human +DTXSID9034361 Css NA 1.026 mg/L PBTK NA 50% Human Human +DTXSID9034361 Css NA 2.721 mg/L PBTK NA 95% Human Human DTXSID9034361 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9034361 Fup 0.488 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9034361 Vd NA 2.361 L/kg 1compartment NA NA Rat Human -DTXSID9034361 Days.Css NA 249 Days PBTK NA NA Rat Human -DTXSID9034361 TK.Half.Life NA 230.8 hours 1compartment NA NA Rat Human -DTXSID9034361 Css NA 34.94 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034361 Css NA 76.98 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034361 Css NA 23.73 mg/L PBTK NA 50% Rat Human -DTXSID9034361 Css NA 46.98 mg/L PBTK NA 95% Rat Human -DTXSID9034365 Clint NA 7.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9034365 Fup NA 0.0476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9034365 Vd NA 0.4949 L/kg 1compartment NA NA Human Human +DTXSID9034361 Vd NA 0.7903 L/kg 1compartment NA NA Rat Human +DTXSID9034361 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9034361 TK.Half.Life NA 3.582 hours 1compartment NA NA Rat Human +DTXSID9034361 Css NA 0.07958 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034361 Css NA 0.1934 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034361 Css NA 0.0642 mg/L PBTK NA 50% Rat Human +DTXSID9034361 Css NA 0.1314 mg/L PBTK NA 95% Rat Human +DTXSID9034365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9034365 Fup 0.0576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9034365 Vd NA 0.5475 L/kg 1compartment NA NA Human Human DTXSID9034365 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9034365 TK.Half.Life NA 5.239 hours 1compartment NA NA Human Human -DTXSID9034365 Css NA 1.642 mg/L 3compartmentss NA 50% Human Human -DTXSID9034365 Css NA 13.02 mg/L 3compartmentss NA 95% Human Human -DTXSID9034365 Css NA 1.071 mg/L PBTK NA 50% Human Human -DTXSID9034365 Css NA 7.864 mg/L PBTK NA 95% Human Human -DTXSID9034365 Clint NA 7.596 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9034365 Fup NA 0.0476 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9034365 Vd NA 0.4747 L/kg 1compartment NA NA Rat Human +DTXSID9034365 TK.Half.Life NA 2.07 hours 1compartment NA NA Human Human +DTXSID9034365 Css NA 0.4229 mg/L 3compartmentss NA 50% Human Human +DTXSID9034365 Css NA 3.552 mg/L 3compartmentss NA 95% Human Human +DTXSID9034365 Css NA 0.2814 mg/L PBTK NA 50% Human Human +DTXSID9034365 Css NA 2.22 mg/L PBTK NA 95% Human Human +DTXSID9034365 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9034365 Fup 0.0576 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9034365 Vd NA 0.5263 L/kg 1compartment NA NA Rat Human DTXSID9034365 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9034365 TK.Half.Life NA 3.172 hours 1compartment NA NA Rat Human -DTXSID9034365 Css NA 0.8898 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034365 Css NA 5.227 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034365 Css NA 0.5442 mg/L PBTK NA 50% Rat Human -DTXSID9034365 Css NA 2.956 mg/L PBTK NA 95% Rat Human +DTXSID9034365 TK.Half.Life NA 1.242 hours 1compartment NA NA Rat Human +DTXSID9034365 Css NA 0.02027 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034365 Css NA 0.1903 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034365 Css NA 0.01319 mg/L PBTK NA 50% Rat Human +DTXSID9034365 Css NA 0.1145 mg/L PBTK NA 95% Rat Human DTXSID9034490 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9034490 Fup NA 0.5996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9034490 Vd NA 0.6247 L/kg 1compartment NA NA Human Human DTXSID9034490 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9034490 TK.Half.Life NA 6.743 hours 1compartment NA NA Human Human -DTXSID9034490 Css NA 1.26 mg/L 3compartmentss NA 50% Human Human -DTXSID9034490 Css NA 8.118 mg/L 3compartmentss NA 95% Human Human -DTXSID9034490 Css NA 0.9848 mg/L PBTK NA 50% Human Human -DTXSID9034490 Css NA 5.06 mg/L PBTK NA 95% Human Human +DTXSID9034490 Css NA 1.071 mg/L 3compartmentss NA 50% Human Human +DTXSID9034490 Css NA 7.312 mg/L 3compartmentss NA 95% Human Human +DTXSID9034490 Css NA 0.8426 mg/L PBTK NA 50% Human Human +DTXSID9034490 Css NA 4.541 mg/L PBTK NA 95% Human Human DTXSID9034490 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9034490 Fup NA 0.5996 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9034490 Vd NA 0.6468 L/kg 1compartment NA NA Rat Human DTXSID9034490 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9034490 TK.Half.Life NA 2.379 hours 1compartment NA NA Rat Human -DTXSID9034490 Css NA 0.334 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034490 Css NA 2.002 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034490 Css NA 0.2496 mg/L PBTK NA 50% Rat Human -DTXSID9034490 Css NA 1.17 mg/L PBTK NA 95% Rat Human +DTXSID9034490 Css NA 0.02038 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034490 Css NA 0.1719 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034490 Css NA 0.01544 mg/L PBTK NA 50% Rat Human +DTXSID9034490 Css NA 0.1063 mg/L PBTK NA 95% Rat Human DTXSID9034492 Clint 10 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9034492 Fup 0.051 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9034492 Vd NA 0.2313 L/kg 1compartment NA NA Human Human +DTXSID9034492 Vd NA 0.3557 L/kg 1compartment NA NA Human Human DTXSID9034492 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9034492 TK.Half.Life NA 1.83 hours 1compartment NA NA Human Human -DTXSID9034492 Css NA 0.8592 mg/L 3compartmentss NA 50% Human Human -DTXSID9034492 Css NA 5.089 mg/L 3compartmentss NA 95% Human Human -DTXSID9034492 Css NA 0.5192 mg/L PBTK NA 50% Human Human -DTXSID9034492 Css NA 3.029 mg/L PBTK NA 95% Human Human +DTXSID9034492 TK.Half.Life NA 2.849 hours 1compartment NA NA Human Human +DTXSID9034492 Css NA 0.7938 mg/L 3compartmentss NA 50% Human Human +DTXSID9034492 Css NA 4.712 mg/L 3compartmentss NA 95% Human Human +DTXSID9034492 Css NA 0.5124 mg/L PBTK NA 50% Human Human +DTXSID9034492 Css NA 2.957 mg/L PBTK NA 95% Human Human DTXSID9034492 Clint 10 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9034492 Fup 0.051 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9034492 Vd NA 0.2308 L/kg 1compartment NA NA Rat Human +DTXSID9034492 Vd NA 0.3463 L/kg 1compartment NA NA Rat Human DTXSID9034492 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9034492 TK.Half.Life NA 1.158 hours 1compartment NA NA Rat Human -DTXSID9034492 Css NA 0.4668 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034492 Css NA 1.965 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034492 Css NA 0.2654 mg/L PBTK NA 50% Rat Human -DTXSID9034492 Css NA 1.101 mg/L PBTK NA 95% Rat Human +DTXSID9034492 TK.Half.Life NA 1.761 hours 1compartment NA NA Rat Human +DTXSID9034492 Css NA 0.09984 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034492 Css NA 0.44 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034492 Css NA 0.06264 mg/L PBTK NA 50% Rat Human +DTXSID9034492 Css NA 0.2691 mg/L PBTK NA 95% Rat Human +DTXSID9034496 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9034496 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9034496 Vd NA 0.3679 L/kg 1compartment NA NA Human Human +DTXSID9034496 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9034496 TK.Half.Life NA 4.868 hours 1compartment NA NA Human Human +DTXSID9034496 Css NA 1.356 mg/L 3compartmentss NA 50% Human Human +DTXSID9034496 Css NA 6.606 mg/L 3compartmentss NA 95% Human Human +DTXSID9034496 Css NA 0.9562 mg/L PBTK NA 50% Human Human +DTXSID9034496 Css NA 4.104 mg/L PBTK NA 95% Human Human +DTXSID9034496 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9034496 Fup 0.489 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9034496 Vd NA 0.3933 L/kg 1compartment NA NA Rat Human +DTXSID9034496 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9034496 TK.Half.Life NA 1.774 hours 1compartment NA NA Rat Human +DTXSID9034496 Css NA 0.03408 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034496 Css NA 0.2206 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034496 Css NA 0.02324 mg/L PBTK NA 50% Rat Human +DTXSID9034496 Css NA 0.1325 mg/L PBTK NA 95% Rat Human DTXSID9034573 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9034573 Fup 0.01566 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9034573 Vd NA 0.1901 L/kg 1compartment NA NA Human Human DTXSID9034573 Days.Css NA 16 Days PBTK NA NA Human Human DTXSID9034573 TK.Half.Life NA 78.53 hours 1compartment NA NA Human Human -DTXSID9034573 Css NA 71.04 mg/L 3compartmentss NA 50% Human Human -DTXSID9034573 Css NA 435.8 mg/L 3compartmentss NA 95% Human Human -DTXSID9034573 Css NA 41.64 mg/L PBTK NA 50% Human Human -DTXSID9034573 Css NA 249.1 mg/L PBTK NA 95% Human Human +DTXSID9034573 Css NA 61.37 mg/L 3compartmentss NA 50% Human Human +DTXSID9034573 Css NA 384.2 mg/L 3compartmentss NA 95% Human Human +DTXSID9034573 Css NA 35.86 mg/L PBTK NA 50% Human Human +DTXSID9034573 Css NA 223.2 mg/L PBTK NA 95% Human Human DTXSID9034573 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9034573 Fup 0.01566 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human DTXSID9034573 Vd NA 0.1875 L/kg 1compartment NA NA Rat Human DTXSID9034573 Days.Css NA 4 Days PBTK NA NA Rat Human DTXSID9034573 TK.Half.Life NA 26.4 hours 1compartment NA NA Rat Human -DTXSID9034573 Css NA 20.27 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034573 Css NA 105.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034573 Css NA 11.08 mg/L PBTK NA 50% Rat Human -DTXSID9034573 Css NA 57.2 mg/L PBTK NA 95% Rat Human +DTXSID9034573 Css NA 1.419 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034573 Css NA 11 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034573 Css NA 0.789 mg/L PBTK NA 50% Rat Human +DTXSID9034573 Css NA 6.137 mg/L PBTK NA 95% Rat Human DTXSID9034650 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9034650 Fup 0.009462 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human DTXSID9034650 Vd NA 0.1655 L/kg 1compartment NA NA Human Human DTXSID9034650 Days.Css NA 26 Days PBTK NA NA Human Human DTXSID9034650 TK.Half.Life NA 113.1 hours 1compartment NA NA Human Human -DTXSID9034650 Css NA 105 mg/L 3compartmentss NA 50% Human Human -DTXSID9034650 Css NA 718.4 mg/L 3compartmentss NA 95% Human Human -DTXSID9034650 Css NA 69.66 mg/L PBTK NA 50% Human Human -DTXSID9034650 Css NA 421.3 mg/L PBTK NA 95% Human Human +DTXSID9034650 Css NA 89.66 mg/L 3compartmentss NA 50% Human Human +DTXSID9034650 Css NA 538.5 mg/L 3compartmentss NA 95% Human Human +DTXSID9034650 Css NA 59.8 mg/L PBTK NA 50% Human Human +DTXSID9034650 Css NA 359.2 mg/L PBTK NA 95% Human Human DTXSID9034650 Clint 9.948 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID9034650 Fup 0.005002 NA NA https://doi.org/10.1093/toxsci/kft012 NA Rat Rat DTXSID9034650 Vd NA 0.1612 L/kg 1compartment NA NA Rat Rat DTXSID9034650 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9034650 TK.Half.Life NA 7.733 hours 1compartment NA NA Rat Rat -DTXSID9034650 Css NA 6.669 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9034650 Css NA 51.3 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9034650 Css NA 4.173 mg/L PBTK NA 50% Rat Rat -DTXSID9034650 Css NA 28.66 mg/L PBTK NA 95% Rat Rat +DTXSID9034650 Css NA 0.4671 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9034650 Css NA 4.689 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9034650 Css NA 0.3163 mg/L PBTK NA 50% Rat Rat +DTXSID9034650 Css NA 3.222 mg/L PBTK NA 95% Rat Rat +DTXSID90346601 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90346601 Fup 0.505 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90346601 Vd NA 0.6939 L/kg 1compartment NA NA Human Human +DTXSID90346601 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90346601 TK.Half.Life NA 9.051 hours 1compartment NA NA Human Human +DTXSID90346601 Css NA 1.396 mg/L 3compartmentss NA 50% Human Human +DTXSID90346601 Css NA 7.576 mg/L 3compartmentss NA 95% Human Human +DTXSID90346601 Css NA 1.073 mg/L PBTK NA 50% Human Human +DTXSID90346601 Css NA 4.836 mg/L PBTK NA 95% Human Human +DTXSID90346601 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90346601 Fup 0.505 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90346601 Vd NA 0.6582 L/kg 1compartment NA NA Rat Human +DTXSID90346601 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90346601 TK.Half.Life NA 2.886 hours 1compartment NA NA Rat Human +DTXSID90346601 Css NA 0.08635 mg/L 3compartmentss NA 50% Rat Human +DTXSID90346601 Css NA 0.4132 mg/L 3compartmentss NA 95% Rat Human +DTXSID90346601 Css NA 0.06561 mg/L PBTK NA 50% Rat Human +DTXSID90346601 Css NA 0.2526 mg/L PBTK NA 95% Rat Human DTXSID9034816 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9034816 Fup 0.898 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9034816 Vd NA 1.291 L/kg 1compartment NA NA Human Human DTXSID9034816 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9034816 TK.Half.Life NA 9.332 hours 1compartment NA NA Human Human -DTXSID9034816 Css NA 0.2129 mg/L 3compartmentss NA 50% Human Human -DTXSID9034816 Css NA 0.7865 mg/L 3compartmentss NA 95% Human Human -DTXSID9034816 Css NA 0.195 mg/L PBTK NA 50% Human Human -DTXSID9034816 Css NA 0.6479 mg/L PBTK NA 95% Human Human +DTXSID9034816 Css NA 0.203 mg/L 3compartmentss NA 50% Human Human +DTXSID9034816 Css NA 0.7416 mg/L 3compartmentss NA 95% Human Human +DTXSID9034816 Css NA 0.1852 mg/L PBTK NA 50% Human Human +DTXSID9034816 Css NA 0.6162 mg/L PBTK NA 95% Human Human DTXSID9034816 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9034816 Fup 0.898 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9034816 Vd NA 1.311 L/kg 1compartment NA NA Rat Human DTXSID9034816 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9034816 TK.Half.Life NA 3.221 hours 1compartment NA NA Rat Human -DTXSID9034816 Css NA 0.08521 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034816 Css NA 0.2338 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034816 Css NA 0.07844 mg/L PBTK NA 50% Rat Human -DTXSID9034816 Css NA 0.1775 mg/L PBTK NA 95% Rat Human +DTXSID9034816 Css NA 0.01908 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034816 Css NA 0.05319 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034816 Css NA 0.0182 mg/L PBTK NA 50% Rat Human +DTXSID9034816 Css NA 0.04242 mg/L PBTK NA 95% Rat Human DTXSID9034818 Clint 429 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9034818 Fup 0.553 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9034818 Vd NA 0.5212 L/kg 1compartment NA NA Human Human DTXSID9034818 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9034818 TK.Half.Life NA 0.3669 hours 1compartment NA NA Human Human -DTXSID9034818 Css NA 0.001714 mg/L 3compartmentss NA 50% Human Human -DTXSID9034818 Css NA 0.01186 mg/L 3compartmentss NA 95% Human Human -DTXSID9034818 Css NA 0.001316 mg/L PBTK NA 50% Human Human -DTXSID9034818 Css NA 0.008676 mg/L PBTK NA 95% Human Human +DTXSID9034818 Css NA 0.0004058 mg/L 3compartmentss NA 50% Human Human +DTXSID9034818 Css NA 0.007339 mg/L 3compartmentss NA 95% Human Human +DTXSID9034818 Css NA 0.0003121 mg/L PBTK NA 50% Human Human +DTXSID9034818 Css NA 0.005295 mg/L PBTK NA 95% Human Human DTXSID9034818 Clint 429 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9034818 Fup 0.553 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9034818 Vd NA 0.5272 L/kg 1compartment NA NA Rat Human DTXSID9034818 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9034818 TK.Half.Life NA 0.162 hours 1compartment NA NA Rat Human -DTXSID9034818 Css NA 0.0009332 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034818 Css NA 0.005152 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034818 Css NA 0.0006993 mg/L PBTK NA 50% Rat Human -DTXSID9034818 Css NA 0.003583 mg/L PBTK NA 95% Rat Human +DTXSID9034818 Css NA 1.752e-05 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034818 Css NA 0.0003717 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034818 Css NA 1.364e-05 mg/L PBTK NA 50% Rat Human +DTXSID9034818 Css NA 0.0002688 mg/L PBTK NA 95% Rat Human DTXSID9034864 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9034864 Fup 0.00891 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9034864 Vd NA 0.1774 L/kg 1compartment NA NA Human Human -DTXSID9034864 Days.Css NA 28 Days PBTK NA NA Human Human -DTXSID9034864 TK.Half.Life NA 128.8 hours 1compartment NA NA Human Human -DTXSID9034864 Css NA 29.32 mg/L 3compartmentss NA 50% Human Human -DTXSID9034864 Css NA 131.2 mg/L 3compartmentss NA 95% Human Human -DTXSID9034864 Css NA 17.07 mg/L PBTK NA 50% Human Human -DTXSID9034864 Css NA 77.02 mg/L PBTK NA 95% Human Human +DTXSID9034864 Vd NA 0.1968 L/kg 1compartment NA NA Human Human +DTXSID9034864 Days.Css NA 32 Days PBTK NA NA Human Human +DTXSID9034864 TK.Half.Life NA 142.9 hours 1compartment NA NA Human Human +DTXSID9034864 Css NA 10.37 mg/L 3compartmentss NA 50% Human Human +DTXSID9034864 Css NA 53.78 mg/L 3compartmentss NA 95% Human Human +DTXSID9034864 Css NA 6.11 mg/L PBTK NA 50% Human Human +DTXSID9034864 Css NA 31.52 mg/L PBTK NA 95% Human Human DTXSID9034864 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9034864 Fup 0.00891 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9034864 Vd NA 0.1754 L/kg 1compartment NA NA Rat Human -DTXSID9034864 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID9034864 TK.Half.Life NA 43.4 hours 1compartment NA NA Rat Human -DTXSID9034864 Css NA 12.62 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034864 Css NA 44.39 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034864 Css NA 6.886 mg/L PBTK NA 50% Rat Human -DTXSID9034864 Css NA 24.06 mg/L PBTK NA 95% Rat Human +DTXSID9034864 Vd NA 0.1924 L/kg 1compartment NA NA Rat Human +DTXSID9034864 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID9034864 TK.Half.Life NA 47.61 hours 1compartment NA NA Rat Human +DTXSID9034864 Css NA 0.07264 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034864 Css NA 0.2922 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034864 Css NA 0.04001 mg/L PBTK NA 50% Rat Human +DTXSID9034864 Css NA 0.1593 mg/L PBTK NA 95% Rat Human DTXSID9034868 Clint 10.37 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human -DTXSID9034868 Fup 0 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Human Human +DTXSID9034868 Fup 0.0419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9034868 Vd NA 197.1 L/kg 1compartment NA NA Human Human +DTXSID9034868 Days.Css NA 441 Days PBTK NA NA Human Human +DTXSID9034868 TK.Half.Life NA 1742 hours 1compartment NA NA Human Human +DTXSID9034868 Css NA 0.0369 mg/L 3compartmentss NA 50% Human Human +DTXSID9034868 Css NA 0.5448 mg/L 3compartmentss NA 95% Human Human +DTXSID9034868 Css NA 0.8224 mg/L PBTK NA 50% Human Human +DTXSID9034868 Css NA 5.488 mg/L PBTK NA 95% Human Human DTXSID9034868 Clint 10.37 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID9034868 Fup 0 NA NA https://doi.org/10.1093/toxsci/kfr254 NA Rat Human -DTXSID9034997 Clint 16.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9034997 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9034997 Vd NA 132.9 L/kg 1compartment NA NA Human Human -DTXSID9034997 Days.Css NA 1360 Days PBTK NA NA Human Human -DTXSID9034997 TK.Half.Life NA 5085 hours 1compartment NA NA Human Human -DTXSID9034997 Css NA 0.1907 mg/L 3compartmentss NA 50% Human Human -DTXSID9034997 Css NA 1.084 mg/L 3compartmentss NA 95% Human Human -DTXSID9034997 Css NA 3.184 mg/L PBTK NA 50% Human Human -DTXSID9034997 Css NA 16.59 mg/L PBTK NA 95% Human Human -DTXSID9034997 Clint 16.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9034997 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9034997 Vd NA 115.8 L/kg 1compartment NA NA Rat Human -DTXSID9034997 Days.Css NA 850 Days PBTK NA NA Rat Human -DTXSID9034997 TK.Half.Life NA 763.7 hours 1compartment NA NA Rat Human -DTXSID9034997 Css NA 0.09674 mg/L 3compartmentss NA 50% Rat Human -DTXSID9034997 Css NA 0.3812 mg/L 3compartmentss NA 95% Rat Human -DTXSID9034997 Css NA 1.711 mg/L PBTK NA 50% Rat Human -DTXSID9034997 Css NA 7.16 mg/L PBTK NA 95% Rat Human -DTXSID9035175 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9035175 Fup NA 0.6867 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9035175 Vd NA 2.633 L/kg 1compartment NA NA Human Human -DTXSID9035175 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9035175 TK.Half.Life NA 4.051 hours 1compartment NA NA Human Human -DTXSID9035175 Css NA 0.1105 mg/L 3compartmentss NA 50% Human Human -DTXSID9035175 Css NA 1.084 mg/L 3compartmentss NA 95% Human Human -DTXSID9035175 Css NA 0.1199 mg/L PBTK NA 50% Human Human -DTXSID9035175 Css NA 0.8362 mg/L PBTK NA 95% Human Human -DTXSID9035175 Clint NA 4.137 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9035175 Fup NA 0.6867 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9035175 Vd NA 2.674 L/kg 1compartment NA NA Rat Human -DTXSID9035175 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9035175 TK.Half.Life NA 2.285 hours 1compartment NA NA Rat Human -DTXSID9035175 Css NA 0.05017 mg/L 3compartmentss NA 50% Rat Human -DTXSID9035175 Css NA 0.455 mg/L 3compartmentss NA 95% Rat Human -DTXSID9035175 Css NA 0.05496 mg/L PBTK NA 50% Rat Human -DTXSID9035175 Css NA 0.3071 mg/L PBTK NA 95% Rat Human -DTXSID9035204 Clint NA 151.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9035204 Fup NA 0.0097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9035204 Vd NA 17.81 L/kg 1compartment NA NA Human Human -DTXSID9035204 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID9035204 TK.Half.Life NA 80.58 hours 1compartment NA NA Human Human -DTXSID9035204 Css NA 0.185 mg/L 3compartmentss NA 50% Human Human -DTXSID9035204 Css NA 1.097 mg/L 3compartmentss NA 95% Human Human -DTXSID9035204 Css NA 0.3522 mg/L PBTK NA 50% Human Human -DTXSID9035204 Css NA 1.955 mg/L PBTK NA 95% Human Human -DTXSID9035204 Clint NA 151.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9035204 Fup NA 0.0097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9035204 Vd NA 14.39 L/kg 1compartment NA NA Rat Human -DTXSID9035204 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID9035204 TK.Half.Life NA 12.47 hours 1compartment NA NA Rat Human -DTXSID9035204 Css NA 0.09851 mg/L 3compartmentss NA 50% Rat Human -DTXSID9035204 Css NA 0.4162 mg/L 3compartmentss NA 95% Rat Human -DTXSID9035204 Css NA 0.191 mg/L PBTK NA 50% Rat Human -DTXSID9035204 Css NA 0.819 mg/L PBTK NA 95% Rat Human -DTXSID9035620 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9035620 Fup NA 0.4778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9035620 Vd NA 2.01 L/kg 1compartment NA NA Human Human -DTXSID9035620 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID9035620 TK.Half.Life NA 43.32 hours 1compartment NA NA Human Human -DTXSID9035620 Css NA 2.163 mg/L 3compartmentss NA 50% Human Human -DTXSID9035620 Css NA 9.115 mg/L 3compartmentss NA 95% Human Human -DTXSID9035620 Css NA 1.801 mg/L PBTK NA 50% Human Human -DTXSID9035620 Css NA 6.163 mg/L PBTK NA 95% Human Human -DTXSID9035620 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9035620 Fup NA 0.4778 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9035620 Vd NA 1.618 L/kg 1compartment NA NA Rat Human -DTXSID9035620 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9035620 TK.Half.Life NA 8.523 hours 1compartment NA NA Rat Human -DTXSID9035620 Css NA 0.5878 mg/L 3compartmentss NA 50% Rat Human -DTXSID9035620 Css NA 2.039 mg/L 3compartmentss NA 95% Rat Human -DTXSID9035620 Css NA 0.4713 mg/L PBTK NA 50% Rat Human -DTXSID9035620 Css NA 1.296 mg/L PBTK NA 95% Rat Human -DTXSID9035753 Clint NA 10.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9035753 Fup NA 0.4051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9035753 Vd NA 2.337 L/kg 1compartment NA NA Human Human -DTXSID9035753 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9035753 TK.Half.Life NA 2.957 hours 1compartment NA NA Human Human -DTXSID9035753 Css NA 0.07025 mg/L 3compartmentss NA 50% Human Human -DTXSID9035753 Css NA 0.5461 mg/L 3compartmentss NA 95% Human Human -DTXSID9035753 Css NA 0.07166 mg/L PBTK NA 50% Human Human -DTXSID9035753 Css NA 0.4587 mg/L PBTK NA 95% Human Human -DTXSID9035753 Clint NA 10.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9035753 Fup NA 0.4051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9035753 Vd NA 2.342 L/kg 1compartment NA NA Rat Human -DTXSID9035753 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9035753 TK.Half.Life NA 1.678 hours 1compartment NA NA Rat Human -DTXSID9035753 Css NA 0.0346 mg/L 3compartmentss NA 50% Rat Human -DTXSID9035753 Css NA 0.2279 mg/L 3compartmentss NA 95% Rat Human -DTXSID9035753 Css NA 0.03568 mg/L PBTK NA 50% Rat Human -DTXSID9035753 Css NA 0.1746 mg/L PBTK NA 95% Rat Human -DTXSID9036226 Clint NA 6.789 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9036226 Fup NA 0.1593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9036226 Vd NA 0.2926 L/kg 1compartment NA NA Human Human -DTXSID9036226 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9036226 TK.Half.Life NA 1.19 hours 1compartment NA NA Human Human -DTXSID9036226 Css NA 0.5019 mg/L 3compartmentss NA 50% Human Human -DTXSID9036226 Css NA 3.092 mg/L 3compartmentss NA 95% Human Human -DTXSID9036226 Css NA 0.3162 mg/L PBTK NA 50% Human Human -DTXSID9036226 Css NA 1.866 mg/L PBTK NA 95% Human Human -DTXSID9036226 Clint NA 6.789 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9036226 Fup NA 0.1593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9036226 Vd NA 0.2898 L/kg 1compartment NA NA Rat Human +DTXSID9034868 Fup 0.0419 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9034868 Vd NA 173.9 L/kg 1compartment NA NA Rat Human +DTXSID9034868 Days.Css NA 274 Days PBTK NA NA Rat Human +DTXSID9034868 TK.Half.Life NA 847.1 hours 1compartment NA NA Rat Human +DTXSID9034868 Css NA 0.001472 mg/L 3compartmentss NA 50% Rat Human +DTXSID9034868 Css NA 0.024 mg/L 3compartmentss NA 95% Rat Human +DTXSID9034868 Css NA 0.03824 mg/L PBTK NA 50% Rat Human +DTXSID9034868 Css NA 0.2802 mg/L PBTK NA 95% Rat Human +DTXSID90349379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90349379 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90349379 Vd NA 2.095 L/kg 1compartment NA NA Human Human +DTXSID90349379 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90349379 TK.Half.Life NA 6.627 hours 1compartment NA NA Human Human +DTXSID90349379 Css NA 0.3364 mg/L 3compartmentss NA 50% Human Human +DTXSID90349379 Css NA 2.358 mg/L 3compartmentss NA 95% Human Human +DTXSID90349379 Css NA 0.2294 mg/L PBTK NA 50% Human Human +DTXSID90349379 Css NA 1.512 mg/L PBTK NA 95% Human Human +DTXSID90349379 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90349379 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90349379 Vd NA 1.59 L/kg 1compartment NA NA Rat Human +DTXSID90349379 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90349379 TK.Half.Life NA 2.133 hours 1compartment NA NA Rat Human +DTXSID90349379 Css NA 0.04284 mg/L 3compartmentss NA 50% Rat Human +DTXSID90349379 Css NA 0.2354 mg/L 3compartmentss NA 95% Rat Human +DTXSID90349379 Css NA 0.0289 mg/L PBTK NA 50% Rat Human +DTXSID90349379 Css NA 0.1509 mg/L PBTK NA 95% Rat Human +DTXSID9035175 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9035175 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9035175 Vd NA 3.918 L/kg 1compartment NA NA Human Human +DTXSID9035175 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID9035175 TK.Half.Life NA 43.95 hours 1compartment NA NA Human Human +DTXSID9035175 Css NA 0.7476 mg/L 3compartmentss NA 50% Human Human +DTXSID9035175 Css NA 7.074 mg/L 3compartmentss NA 95% Human Human +DTXSID9035175 Css NA 0.978 mg/L PBTK NA 50% Human Human +DTXSID9035175 Css NA 5.272 mg/L PBTK NA 95% Human Human +DTXSID9035175 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9035175 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9035175 Vd NA 3.977 L/kg 1compartment NA NA Rat Human +DTXSID9035175 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9035175 TK.Half.Life NA 14.63 hours 1compartment NA NA Rat Human +DTXSID9035175 Css NA 0.04418 mg/L 3compartmentss NA 50% Rat Human +DTXSID9035175 Css NA 0.3986 mg/L 3compartmentss NA 95% Rat Human +DTXSID9035175 Css NA 0.06002 mg/L PBTK NA 50% Rat Human +DTXSID9035175 Css NA 0.2892 mg/L PBTK NA 95% Rat Human +DTXSID9035620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9035620 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9035620 Vd NA 1.578 L/kg 1compartment NA NA Human Human +DTXSID9035620 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9035620 TK.Half.Life NA 2.326 hours 1compartment NA NA Human Human +DTXSID9035620 Css NA 0.0883 mg/L 3compartmentss NA 50% Human Human +DTXSID9035620 Css NA 0.6042 mg/L 3compartmentss NA 95% Human Human +DTXSID9035620 Css NA 0.06626 mg/L PBTK NA 50% Human Human +DTXSID9035620 Css NA 0.4174 mg/L PBTK NA 95% Human Human +DTXSID9035620 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9035620 Fup 0.276 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9035620 Vd NA 1.262 L/kg 1compartment NA NA Rat Human +DTXSID9035620 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9035620 TK.Half.Life NA 0.9024 hours 1compartment NA NA Rat Human +DTXSID9035620 Css NA 0.01086 mg/L 3compartmentss NA 50% Rat Human +DTXSID9035620 Css NA 0.06118 mg/L 3compartmentss NA 95% Rat Human +DTXSID9035620 Css NA 0.008105 mg/L PBTK NA 50% Rat Human +DTXSID9035620 Css NA 0.04284 mg/L PBTK NA 95% Rat Human +DTXSID9035753 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9035753 Fup 0.605 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9035753 Vd NA 3.249 L/kg 1compartment NA NA Human Human +DTXSID9035753 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9035753 TK.Half.Life NA 34.8 hours 1compartment NA NA Human Human +DTXSID9035753 Css NA 0.7594 mg/L 3compartmentss NA 50% Human Human +DTXSID9035753 Css NA 6.942 mg/L 3compartmentss NA 95% Human Human +DTXSID9035753 Css NA 0.9494 mg/L PBTK NA 50% Human Human +DTXSID9035753 Css NA 5.073 mg/L PBTK NA 95% Human Human +DTXSID9035753 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9035753 Fup 0.605 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9035753 Vd NA 3.277 L/kg 1compartment NA NA Rat Human +DTXSID9035753 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9035753 TK.Half.Life NA 11.95 hours 1compartment NA NA Rat Human +DTXSID9035753 Css NA 0.04464 mg/L 3compartmentss NA 50% Rat Human +DTXSID9035753 Css NA 0.3938 mg/L 3compartmentss NA 95% Rat Human +DTXSID9035753 Css NA 0.05783 mg/L PBTK NA 50% Rat Human +DTXSID9035753 Css NA 0.2804 mg/L PBTK NA 95% Rat Human +DTXSID9036226 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9036226 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9036226 Vd NA 1.062 L/kg 1compartment NA NA Human Human +DTXSID9036226 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9036226 TK.Half.Life NA 18.52 hours 1compartment NA NA Human Human +DTXSID9036226 Css NA 1.765 mg/L 3compartmentss NA 50% Human Human +DTXSID9036226 Css NA 7.864 mg/L 3compartmentss NA 95% Human Human +DTXSID9036226 Css NA 1.394 mg/L PBTK NA 50% Human Human +DTXSID9036226 Css NA 5.178 mg/L PBTK NA 95% Human Human +DTXSID9036226 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9036226 Fup 0.398 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9036226 Vd NA 0.9474 L/kg 1compartment NA NA Rat Human DTXSID9036226 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9036226 TK.Half.Life NA 0.7019 hours 1compartment NA NA Rat Human -DTXSID9036226 Css NA 0.2647 mg/L 3compartmentss NA 50% Rat Human -DTXSID9036226 Css NA 1.225 mg/L 3compartmentss NA 95% Rat Human -DTXSID9036226 Css NA 0.1567 mg/L PBTK NA 50% Rat Human -DTXSID9036226 Css NA 0.6968 mg/L PBTK NA 95% Rat Human -DTXSID9036438 Clint NA 41.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9036438 Fup NA 0.0135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9036438 Vd NA 1.618 L/kg 1compartment NA NA Human Human -DTXSID9036438 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9036438 TK.Half.Life NA 11.28 hours 1compartment NA NA Human Human -DTXSID9036438 Css NA 1.057 mg/L 3compartmentss NA 50% Human Human -DTXSID9036438 Css NA 9.433 mg/L 3compartmentss NA 95% Human Human -DTXSID9036438 Css NA 0.6632 mg/L PBTK NA 50% Human Human -DTXSID9036438 Css NA 5.764 mg/L PBTK NA 95% Human Human -DTXSID9036438 Clint NA 41.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9036438 Fup NA 0.0135 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9036438 Vd NA 1.197 L/kg 1compartment NA NA Rat Human -DTXSID9036438 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9036438 TK.Half.Life NA 4.178 hours 1compartment NA NA Rat Human -DTXSID9036438 Css NA 0.5939 mg/L 3compartmentss NA 50% Rat Human -DTXSID9036438 Css NA 4.356 mg/L 3compartmentss NA 95% Rat Human -DTXSID9036438 Css NA 0.3481 mg/L PBTK NA 50% Rat Human -DTXSID9036438 Css NA 2.455 mg/L PBTK NA 95% Rat Human +DTXSID9036226 TK.Half.Life NA 5.34 hours 1compartment NA NA Rat Human +DTXSID9036226 Css NA 0.1125 mg/L 3compartmentss NA 50% Rat Human +DTXSID9036226 Css NA 0.4365 mg/L 3compartmentss NA 95% Rat Human +DTXSID9036226 Css NA 0.08828 mg/L PBTK NA 50% Rat Human +DTXSID9036226 Css NA 0.2753 mg/L PBTK NA 95% Rat Human +DTXSID90363979 Clint 9.77 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90363979 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90363979 Vd NA 0.3734 L/kg 1compartment NA NA Human Human +DTXSID90363979 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90363979 TK.Half.Life NA 0.6515 hours 1compartment NA NA Human Human +DTXSID90363979 Css NA 0.1263 mg/L 3compartmentss NA 50% Human Human +DTXSID90363979 Css NA 0.9059 mg/L 3compartmentss NA 95% Human Human +DTXSID90363979 Css NA 0.08604 mg/L PBTK NA 50% Human Human +DTXSID90363979 Css NA 0.5765 mg/L PBTK NA 95% Human Human +DTXSID90363979 Clint 9.77 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90363979 Fup 0.361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90363979 Vd NA 0.3779 L/kg 1compartment NA NA Rat Human +DTXSID90363979 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90363979 TK.Half.Life NA 0.3625 hours 1compartment NA NA Rat Human +DTXSID90363979 Css NA 0.01546 mg/L 3compartmentss NA 50% Rat Human +DTXSID90363979 Css NA 0.07778 mg/L 3compartmentss NA 95% Rat Human +DTXSID90363979 Css NA 0.01044 mg/L PBTK NA 50% Rat Human +DTXSID90363979 Css NA 0.04842 mg/L PBTK NA 95% Rat Human +DTXSID9036438 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9036438 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9036438 Vd NA 6.864 L/kg 1compartment NA NA Human Human +DTXSID9036438 Days.Css NA 39 Days PBTK NA NA Human Human +DTXSID9036438 TK.Half.Life NA 205.5 hours 1compartment NA NA Human Human +DTXSID9036438 Css NA 2.534 mg/L 3compartmentss NA 50% Human Human +DTXSID9036438 Css NA 15.22 mg/L 3compartmentss NA 95% Human Human +DTXSID9036438 Css NA 2.376 mg/L PBTK NA 50% Human Human +DTXSID9036438 Css NA 14.04 mg/L PBTK NA 95% Human Human +DTXSID9036438 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9036438 Fup 0.0146 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9036438 Vd NA 5.313 L/kg 1compartment NA NA Rat Human +DTXSID9036438 Days.Css NA 23 Days PBTK NA NA Rat Human +DTXSID9036438 TK.Half.Life NA 28.27 hours 1compartment NA NA Rat Human +DTXSID9036438 Css NA 0.3239 mg/L 3compartmentss NA 50% Rat Human +DTXSID9036438 Css NA 1.522 mg/L 3compartmentss NA 95% Rat Human +DTXSID9036438 Css NA 0.3105 mg/L PBTK NA 50% Rat Human +DTXSID9036438 Css NA 1.486 mg/L PBTK NA 95% Rat Human DTXSID9036515 Clint 427 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9036515 Fup 3.71e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9036515 Vd NA 0.2701 L/kg 1compartment NA NA Human Human +DTXSID9036515 Vd NA 0.3893 L/kg 1compartment NA NA Human Human DTXSID9036515 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9036515 TK.Half.Life NA 10.9 hours 1compartment NA NA Human Human -DTXSID9036515 Css NA 2.438 mg/L 3compartmentss NA 50% Human Human -DTXSID9036515 Css NA 21.05 mg/L 3compartmentss NA 95% Human Human -DTXSID9036515 Css NA 1.434 mg/L PBTK NA 50% Human Human -DTXSID9036515 Css NA 12.2 mg/L PBTK NA 95% Human Human +DTXSID9036515 TK.Half.Life NA 10.01 hours 1compartment NA NA Human Human +DTXSID9036515 Css NA 1.548 mg/L 3compartmentss NA 50% Human Human +DTXSID9036515 Css NA 13.63 mg/L 3compartmentss NA 95% Human Human +DTXSID9036515 Css NA 0.9228 mg/L PBTK NA 50% Human Human +DTXSID9036515 Css NA 8.011 mg/L PBTK NA 95% Human Human DTXSID9036515 Clint 427 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9036515 Fup 3.71e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9036515 Vd NA 0.2194 L/kg 1compartment NA NA Rat Human +DTXSID9036515 Vd NA 0.2958 L/kg 1compartment NA NA Rat Human DTXSID9036515 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9036515 TK.Half.Life NA 6.161 hours 1compartment NA NA Rat Human -DTXSID9036515 Css NA 1.674 mg/L 3compartmentss NA 50% Rat Human -DTXSID9036515 Css NA 9.294 mg/L 3compartmentss NA 95% Rat Human -DTXSID9036515 Css NA 0.9103 mg/L PBTK NA 50% Rat Human -DTXSID9036515 Css NA 5.032 mg/L PBTK NA 95% Rat Human -DTXSID9036646 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9036646 Fup NA 0.6143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9036646 Vd NA 1.785 L/kg 1compartment NA NA Human Human -DTXSID9036646 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9036646 TK.Half.Life NA 25.19 hours 1compartment NA NA Human Human -DTXSID9036646 Css NA 1.416 mg/L 3compartmentss NA 50% Human Human -DTXSID9036646 Css NA 8.247 mg/L 3compartmentss NA 95% Human Human -DTXSID9036646 Css NA 1.25 mg/L PBTK NA 50% Human Human -DTXSID9036646 Css NA 5.549 mg/L PBTK NA 95% Human Human -DTXSID9036646 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9036646 Fup NA 0.6143 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9036646 Vd NA 1.495 L/kg 1compartment NA NA Rat Human +DTXSID9036515 TK.Half.Life NA 5.259 hours 1compartment NA NA Rat Human +DTXSID9036515 Css NA 0.2406 mg/L 3compartmentss NA 50% Rat Human +DTXSID9036515 Css NA 1.42 mg/L 3compartmentss NA 95% Rat Human +DTXSID9036515 Css NA 0.1362 mg/L PBTK NA 50% Rat Human +DTXSID9036515 Css NA 0.7996 mg/L PBTK NA 95% Rat Human +DTXSID9036646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9036646 Fup 0.442 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9036646 Vd NA 1.78 L/kg 1compartment NA NA Human Human +DTXSID9036646 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9036646 TK.Half.Life NA 2.036 hours 1compartment NA NA Human Human +DTXSID9036646 Css NA 0.05354 mg/L 3compartmentss NA 50% Human Human +DTXSID9036646 Css NA 0.4125 mg/L 3compartmentss NA 95% Human Human +DTXSID9036646 Css NA 0.04374 mg/L PBTK NA 50% Human Human +DTXSID9036646 Css NA 0.2958 mg/L PBTK NA 95% Human Human +DTXSID9036646 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9036646 Fup 0.442 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9036646 Vd NA 1.449 L/kg 1compartment NA NA Rat Human DTXSID9036646 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9036646 TK.Half.Life NA 5.8 hours 1compartment NA NA Rat Human -DTXSID9036646 Css NA 0.374 mg/L 3compartmentss NA 50% Rat Human -DTXSID9036646 Css NA 2.141 mg/L 3compartmentss NA 95% Rat Human -DTXSID9036646 Css NA 0.3184 mg/L PBTK NA 50% Rat Human -DTXSID9036646 Css NA 1.317 mg/L PBTK NA 95% Rat Human +DTXSID9036646 TK.Half.Life NA 0.7702 hours 1compartment NA NA Rat Human +DTXSID9036646 Css NA 0.006649 mg/L 3compartmentss NA 50% Rat Human +DTXSID9036646 Css NA 0.03983 mg/L 3compartmentss NA 95% Rat Human +DTXSID9036646 Css NA 0.005459 mg/L PBTK NA 50% Rat Human +DTXSID9036646 Css NA 0.02931 mg/L PBTK NA 95% Rat Human DTXSID9036690 Clint 865 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9036690 Fup NA 0.0894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9036690 Vd NA 2.843 L/kg 1compartment NA NA Human Human +DTXSID9036690 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9036690 Vd NA 3.051 L/kg 1compartment NA NA Human Human DTXSID9036690 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9036690 TK.Half.Life NA 2.768 hours 1compartment NA NA Human Human -DTXSID9036690 Css NA 0.02158 mg/L 3compartmentss NA 50% Human Human -DTXSID9036690 Css NA 0.1395 mg/L 3compartmentss NA 95% Human Human -DTXSID9036690 Css NA 0.01495 mg/L PBTK NA 50% Human Human -DTXSID9036690 Css NA 0.09681 mg/L PBTK NA 95% Human Human +DTXSID9036690 TK.Half.Life NA 3.219 hours 1compartment NA NA Human Human +DTXSID9036690 Css NA 0.02776 mg/L 3compartmentss NA 50% Human Human +DTXSID9036690 Css NA 0.1976 mg/L 3compartmentss NA 95% Human Human +DTXSID9036690 Css NA 0.01939 mg/L PBTK NA 50% Human Human +DTXSID9036690 Css NA 0.1342 mg/L PBTK NA 95% Human Human DTXSID9036690 Clint 865 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9036690 Fup NA 0.0894 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9036690 Vd NA 2.137 L/kg 1compartment NA NA Rat Human +DTXSID9036690 Fup 0.127 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9036690 Vd NA 2.291 L/kg 1compartment NA NA Rat Human DTXSID9036690 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9036690 TK.Half.Life NA 0.8436 hours 1compartment NA NA Rat Human -DTXSID9036690 Css NA 0.01217 mg/L 3compartmentss NA 50% Rat Human -DTXSID9036690 Css NA 0.06965 mg/L 3compartmentss NA 95% Rat Human -DTXSID9036690 Css NA 0.008042 mg/L PBTK NA 50% Rat Human -DTXSID9036690 Css NA 0.04475 mg/L PBTK NA 95% Rat Human -DTXSID9036933 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9036933 Fup NA 0.2924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9036933 Vd NA 7726 L/kg 1compartment NA NA Human Human -DTXSID9036933 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID9036933 TK.Half.Life NA 346600000 hours 1compartment NA NA Human Human -DTXSID9036933 Css NA 2.498 mg/L 3compartmentss NA 50% Human Human -DTXSID9036933 Css NA 6.827 mg/L 3compartmentss NA 95% Human Human -DTXSID9036933 Css NA 3613 mg/L PBTK NA 50% Human Human -DTXSID9036933 Css NA 7844 mg/L PBTK NA 95% Human Human -DTXSID9036933 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9036933 Fup NA 0.2924 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9036933 Vd NA 7255 L/kg 1compartment NA NA Rat Human -DTXSID9036933 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID9036933 TK.Half.Life NA 27730000 hours 1compartment NA NA Rat Human -DTXSID9036933 Css NA 0.6056 mg/L 3compartmentss NA 50% Rat Human -DTXSID9036933 Css NA 1.142 mg/L 3compartmentss NA 95% Rat Human -DTXSID9036933 Css NA 965.3 mg/L PBTK NA 50% Rat Human -DTXSID9036933 Css NA 1325 mg/L PBTK NA 95% Rat Human +DTXSID9036690 TK.Half.Life NA 0.9206 hours 1compartment NA NA Rat Human +DTXSID9036690 Css NA 0.00366 mg/L 3compartmentss NA 50% Rat Human +DTXSID9036690 Css NA 0.0232 mg/L 3compartmentss NA 95% Rat Human +DTXSID9036690 Css NA 0.002537 mg/L PBTK NA 50% Rat Human +DTXSID9036690 Css NA 0.01563 mg/L PBTK NA 95% Rat Human DTXSID9037038 Clint NA 2.492 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9037038 Fup NA 0.3604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037038 Vd NA 0.6086 L/kg 1compartment NA NA Human Human +DTXSID9037038 Vd NA 0.6653 L/kg 1compartment NA NA Human Human DTXSID9037038 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9037038 TK.Half.Life NA 2.433 hours 1compartment NA NA Human Human -DTXSID9037038 Css NA 0.4102 mg/L 3compartmentss NA 50% Human Human -DTXSID9037038 Css NA 2.201 mg/L 3compartmentss NA 95% Human Human -DTXSID9037038 Css NA 0.3 mg/L PBTK NA 50% Human Human -DTXSID9037038 Css NA 1.428 mg/L PBTK NA 95% Human Human +DTXSID9037038 TK.Half.Life NA 2.664 hours 1compartment NA NA Human Human +DTXSID9037038 Css NA 0.397 mg/L 3compartmentss NA 50% Human Human +DTXSID9037038 Css NA 2.216 mg/L 3compartmentss NA 95% Human Human +DTXSID9037038 Css NA 0.2933 mg/L PBTK NA 50% Human Human +DTXSID9037038 Css NA 1.439 mg/L PBTK NA 95% Human Human DTXSID9037038 Clint NA 2.492 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9037038 Fup NA 0.3604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037038 Vd NA 0.5926 L/kg 1compartment NA NA Rat Human +DTXSID9037038 Vd NA 0.6349 L/kg 1compartment NA NA Rat Human DTXSID9037038 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9037038 TK.Half.Life NA 1.291 hours 1compartment NA NA Rat Human -DTXSID9037038 Css NA 0.188 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037038 Css NA 0.8118 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037038 Css NA 0.1318 mg/L PBTK NA 50% Rat Human -DTXSID9037038 Css NA 0.4879 mg/L PBTK NA 95% Rat Human +DTXSID9037038 TK.Half.Life NA 1.381 hours 1compartment NA NA Rat Human +DTXSID9037038 Css NA 0.04211 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037038 Css NA 0.1786 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037038 Css NA 0.03096 mg/L PBTK NA 50% Rat Human +DTXSID9037038 Css NA 0.1123 mg/L PBTK NA 95% Rat Human DTXSID9037246 Clint NA 0.02376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9037246 Fup NA 0.9069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037246 Vd NA 1.568 L/kg 1compartment NA NA Human Human -DTXSID9037246 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9037246 TK.Half.Life NA 10.76 hours 1compartment NA NA Human Human -DTXSID9037246 Css NA 0.7652 mg/L 3compartmentss NA 50% Human Human -DTXSID9037246 Css NA 4.946 mg/L 3compartmentss NA 95% Human Human -DTXSID9037246 Css NA 0.7309 mg/L PBTK NA 50% Human Human -DTXSID9037246 Css NA 3.36 mg/L PBTK NA 95% Human Human +DTXSID9037246 Vd NA 0.6996 L/kg 1compartment NA NA Human Human +DTXSID9037246 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9037246 TK.Half.Life NA 4.774 hours 1compartment NA NA Human Human +DTXSID9037246 Css NA 0.7692 mg/L 3compartmentss NA 50% Human Human +DTXSID9037246 Css NA 4.227 mg/L 3compartmentss NA 95% Human Human +DTXSID9037246 Css NA 0.6214 mg/L PBTK NA 50% Human Human +DTXSID9037246 Css NA 2.732 mg/L PBTK NA 95% Human Human DTXSID9037246 Clint NA 0.02376 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9037246 Fup NA 0.9069 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037246 Vd NA 1.552 L/kg 1compartment NA NA Rat Human +DTXSID9037246 Vd NA 0.739 L/kg 1compartment NA NA Rat Human DTXSID9037246 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9037246 TK.Half.Life NA 3.703 hours 1compartment NA NA Rat Human -DTXSID9037246 Css NA 0.1969 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037246 Css NA 1.219 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037246 Css NA 0.1844 mg/L PBTK NA 50% Rat Human -DTXSID9037246 Css NA 0.7741 mg/L PBTK NA 95% Rat Human -DTXSID9037248 Clint NA 193.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037248 Fup NA 0.4276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037248 Vd NA 2.131 L/kg 1compartment NA NA Human Human +DTXSID9037246 TK.Half.Life NA 1.758 hours 1compartment NA NA Rat Human +DTXSID9037246 Css NA 0.01461 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037246 Css NA 0.1049 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037246 Css NA 0.01132 mg/L PBTK NA 50% Rat Human +DTXSID9037246 Css NA 0.06823 mg/L PBTK NA 95% Rat Human +DTXSID9037248 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037248 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037248 Vd NA 1.042 L/kg 1compartment NA NA Human Human DTXSID9037248 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9037248 TK.Half.Life NA 1.174 hours 1compartment NA NA Human Human -DTXSID9037248 Css NA 0.003959 mg/L 3compartmentss NA 50% Human Human -DTXSID9037248 Css NA 0.03841 mg/L 3compartmentss NA 95% Human Human -DTXSID9037248 Css NA 0.004056 mg/L PBTK NA 50% Human Human -DTXSID9037248 Css NA 0.03136 mg/L PBTK NA 95% Human Human -DTXSID9037248 Clint NA 193.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037248 Fup NA 0.4276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037248 Vd NA 2.109 L/kg 1compartment NA NA Rat Human +DTXSID9037248 TK.Half.Life NA 1.558 hours 1compartment NA NA Human Human +DTXSID9037248 Css NA 0.1084 mg/L 3compartmentss NA 50% Human Human +DTXSID9037248 Css NA 0.9805 mg/L 3compartmentss NA 95% Human Human +DTXSID9037248 Css NA 0.09102 mg/L PBTK NA 50% Human Human +DTXSID9037248 Css NA 0.6734 mg/L PBTK NA 95% Human Human +DTXSID9037248 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037248 Fup 0.58 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037248 Vd NA 1.043 L/kg 1compartment NA NA Rat Human DTXSID9037248 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9037248 TK.Half.Life NA 0.5275 hours 1compartment NA NA Rat Human -DTXSID9037248 Css NA 0.002071 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037248 Css NA 0.01672 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037248 Css NA 0.002124 mg/L PBTK NA 50% Rat Human -DTXSID9037248 Css NA 0.01361 mg/L PBTK NA 95% Rat Human -DTXSID9037535 Clint NA 170.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037535 Fup NA 0.1989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037535 Vd NA 1.111 L/kg 1compartment NA NA Human Human +DTXSID9037248 TK.Half.Life NA 0.8528 hours 1compartment NA NA Rat Human +DTXSID9037248 Css NA 0.01226 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037248 Css NA 0.09555 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037248 Css NA 0.01039 mg/L PBTK NA 50% Rat Human +DTXSID9037248 Css NA 0.06217 mg/L PBTK NA 95% Rat Human +DTXSID90373412 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90373412 Fup 0.0671 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90373412 Vd NA 1.399 L/kg 1compartment NA NA Human Human +DTXSID90373412 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90373412 TK.Half.Life NA 5.184 hours 1compartment NA NA Human Human +DTXSID90373412 Css NA 0.4618 mg/L 3compartmentss NA 50% Human Human +DTXSID90373412 Css NA 3.498 mg/L 3compartmentss NA 95% Human Human +DTXSID90373412 Css NA 0.2982 mg/L PBTK NA 50% Human Human +DTXSID90373412 Css NA 2.164 mg/L PBTK NA 95% Human Human +DTXSID90373412 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90373412 Fup 0.0671 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90373412 Vd NA 1.061 L/kg 1compartment NA NA Rat Human +DTXSID90373412 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90373412 TK.Half.Life NA 2.059 hours 1compartment NA NA Rat Human +DTXSID90373412 Css NA 0.05528 mg/L 3compartmentss NA 50% Rat Human +DTXSID90373412 Css NA 0.3432 mg/L 3compartmentss NA 95% Rat Human +DTXSID90373412 Css NA 0.03461 mg/L PBTK NA 50% Rat Human +DTXSID90373412 Css NA 0.2062 mg/L PBTK NA 95% Rat Human +DTXSID9037535 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037535 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037535 Vd NA 1.647 L/kg 1compartment NA NA Human Human DTXSID9037535 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9037535 TK.Half.Life NA 1.005 hours 1compartment NA NA Human Human -DTXSID9037535 Css NA 0.0154 mg/L 3compartmentss NA 50% Human Human -DTXSID9037535 Css NA 0.1132 mg/L 3compartmentss NA 95% Human Human -DTXSID9037535 Css NA 0.01082 mg/L PBTK NA 50% Human Human -DTXSID9037535 Css NA 0.07565 mg/L PBTK NA 95% Human Human -DTXSID9037535 Clint NA 170.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037535 Fup NA 0.1989 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037535 Vd NA 0.9049 L/kg 1compartment NA NA Rat Human +DTXSID9037535 TK.Half.Life NA 2.45 hours 1compartment NA NA Human Human +DTXSID9037535 Css NA 0.08788 mg/L 3compartmentss NA 50% Human Human +DTXSID9037535 Css NA 0.6306 mg/L 3compartmentss NA 95% Human Human +DTXSID9037535 Css NA 0.06626 mg/L PBTK NA 50% Human Human +DTXSID9037535 Css NA 0.448 mg/L PBTK NA 95% Human Human +DTXSID9037535 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037535 Fup 0.278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037535 Vd NA 1.312 L/kg 1compartment NA NA Rat Human DTXSID9037535 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9037535 TK.Half.Life NA 0.3759 hours 1compartment NA NA Rat Human -DTXSID9037535 Css NA 0.008658 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037535 Css NA 0.05278 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037535 Css NA 0.005808 mg/L PBTK NA 50% Rat Human -DTXSID9037535 Css NA 0.03345 mg/L PBTK NA 95% Rat Human +DTXSID9037535 TK.Half.Life NA 0.9355 hours 1compartment NA NA Rat Human +DTXSID9037535 Css NA 0.01104 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037535 Css NA 0.05963 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037535 Css NA 0.008301 mg/L PBTK NA 50% Rat Human +DTXSID9037535 Css NA 0.0412 mg/L PBTK NA 95% Rat Human DTXSID9037539 Clint NA 22.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9037539 Fup NA 0.022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037539 Vd NA 2.408 L/kg 1compartment NA NA Human Human -DTXSID9037539 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9037539 TK.Half.Life NA 26.23 hours 1compartment NA NA Human Human -DTXSID9037539 Css NA 1.57 mg/L 3compartmentss NA 50% Human Human -DTXSID9037539 Css NA 11.55 mg/L 3compartmentss NA 95% Human Human -DTXSID9037539 Css NA 1.031 mg/L PBTK NA 50% Human Human -DTXSID9037539 Css NA 7.228 mg/L PBTK NA 95% Human Human +DTXSID9037539 Vd NA 2.08 L/kg 1compartment NA NA Human Human +DTXSID9037539 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9037539 TK.Half.Life NA 19.82 hours 1compartment NA NA Human Human +DTXSID9037539 Css NA 1.383 mg/L 3compartmentss NA 50% Human Human +DTXSID9037539 Css NA 11.49 mg/L 3compartmentss NA 95% Human Human +DTXSID9037539 Css NA 0.8951 mg/L PBTK NA 50% Human Human +DTXSID9037539 Css NA 7.076 mg/L PBTK NA 95% Human Human DTXSID9037539 Clint NA 22.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9037539 Fup NA 0.022 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037539 Vd NA 1.796 L/kg 1compartment NA NA Rat Human +DTXSID9037539 Vd NA 1.547 L/kg 1compartment NA NA Rat Human DTXSID9037539 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9037539 TK.Half.Life NA 6.883 hours 1compartment NA NA Rat Human -DTXSID9037539 Css NA 0.8625 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037539 Css NA 5.297 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037539 Css NA 0.5387 mg/L PBTK NA 50% Rat Human -DTXSID9037539 Css NA 3.159 mg/L PBTK NA 95% Rat Human +DTXSID9037539 TK.Half.Life NA 6.167 hours 1compartment NA NA Rat Human +DTXSID9037539 Css NA 0.1787 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037539 Css NA 1.151 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037539 Css NA 0.1128 mg/L PBTK NA 50% Rat Human +DTXSID9037539 Css NA 0.7004 mg/L PBTK NA 95% Rat Human DTXSID9037612 Clint 30.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9037612 Fup 0.049 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9037612 Vd NA 1.899 L/kg 1compartment NA NA Human Human DTXSID9037612 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9037612 TK.Half.Life NA 7.743 hours 1compartment NA NA Human Human -DTXSID9037612 Css NA 0.4272 mg/L 3compartmentss NA 50% Human Human -DTXSID9037612 Css NA 2.8 mg/L 3compartmentss NA 95% Human Human -DTXSID9037612 Css NA 0.2845 mg/L PBTK NA 50% Human Human -DTXSID9037612 Css NA 1.8 mg/L PBTK NA 95% Human Human +DTXSID9037612 Css NA 0.4122 mg/L 3compartmentss NA 50% Human Human +DTXSID9037612 Css NA 2.682 mg/L 3compartmentss NA 95% Human Human +DTXSID9037612 Css NA 0.273 mg/L PBTK NA 50% Human Human +DTXSID9037612 Css NA 1.706 mg/L PBTK NA 95% Human Human DTXSID9037612 Clint 30.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9037612 Fup 0.049 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9037612 Vd NA 1.423 L/kg 1compartment NA NA Rat Human DTXSID9037612 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9037612 TK.Half.Life NA 2.63 hours 1compartment NA NA Rat Human -DTXSID9037612 Css NA 0.238 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037612 Css NA 1.293 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037612 Css NA 0.1495 mg/L PBTK NA 50% Rat Human -DTXSID9037612 Css NA 0.7788 mg/L PBTK NA 95% Rat Human -DTXSID9037616 Clint NA 0.8805 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037616 Fup NA 0.5615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037616 Vd NA 0.7268 L/kg 1compartment NA NA Human Human -DTXSID9037616 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9037616 TK.Half.Life NA 3.601 hours 1compartment NA NA Human Human -DTXSID9037616 Css NA 0.5334 mg/L 3compartmentss NA 50% Human Human -DTXSID9037616 Css NA 3.925 mg/L 3compartmentss NA 95% Human Human -DTXSID9037616 Css NA 0.4252 mg/L PBTK NA 50% Human Human -DTXSID9037616 Css NA 2.517 mg/L PBTK NA 95% Human Human -DTXSID9037616 Clint NA 0.8805 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037616 Fup NA 0.5615 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037616 Vd NA 0.7205 L/kg 1compartment NA NA Rat Human +DTXSID9037612 Css NA 0.05314 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037612 Css NA 0.3136 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037612 Css NA 0.03459 mg/L PBTK NA 50% Rat Human +DTXSID9037612 Css NA 0.1988 mg/L PBTK NA 95% Rat Human +DTXSID9037616 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037616 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037616 Vd NA 0.9844 L/kg 1compartment NA NA Human Human +DTXSID9037616 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9037616 TK.Half.Life NA 10.03 hours 1compartment NA NA Human Human +DTXSID9037616 Css NA 1.067 mg/L 3compartmentss NA 50% Human Human +DTXSID9037616 Css NA 7.443 mg/L 3compartmentss NA 95% Human Human +DTXSID9037616 Css NA 0.9121 mg/L PBTK NA 50% Human Human +DTXSID9037616 Css NA 4.834 mg/L PBTK NA 95% Human Human +DTXSID9037616 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037616 Fup 0.656 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037616 Vd NA 0.9349 L/kg 1compartment NA NA Rat Human DTXSID9037616 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9037616 TK.Half.Life NA 1.695 hours 1compartment NA NA Rat Human -DTXSID9037616 Css NA 0.2014 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037616 Css NA 1.359 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037616 Css NA 0.1552 mg/L PBTK NA 50% Rat Human -DTXSID9037616 Css NA 0.8033 mg/L PBTK NA 95% Rat Human +DTXSID9037616 TK.Half.Life NA 3.168 hours 1compartment NA NA Rat Human +DTXSID9037616 Css NA 0.06482 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037616 Css NA 0.4152 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037616 Css NA 0.05525 mg/L PBTK NA 50% Rat Human +DTXSID9037616 Css NA 0.2579 mg/L PBTK NA 95% Rat Human DTXSID9037741 Clint 118 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9037741 Fup 0.0188 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9037741 Vd NA 1.234 L/kg 1compartment NA NA Human Human +DTXSID9037741 Vd NA 1.184 L/kg 1compartment NA NA Human Human DTXSID9037741 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9037741 TK.Half.Life NA 3.088 hours 1compartment NA NA Human Human -DTXSID9037741 Css NA 0.1956 mg/L 3compartmentss NA 50% Human Human -DTXSID9037741 Css NA 1.469 mg/L 3compartmentss NA 95% Human Human -DTXSID9037741 Css NA 0.123 mg/L PBTK NA 50% Human Human -DTXSID9037741 Css NA 0.8921 mg/L PBTK NA 95% Human Human +DTXSID9037741 TK.Half.Life NA 2.96 hours 1compartment NA NA Human Human +DTXSID9037741 Css NA 0.1864 mg/L 3compartmentss NA 50% Human Human +DTXSID9037741 Css NA 1.522 mg/L 3compartmentss NA 95% Human Human +DTXSID9037741 Css NA 0.1168 mg/L PBTK NA 50% Human Human +DTXSID9037741 Css NA 0.9315 mg/L PBTK NA 95% Human Human DTXSID9037741 Clint 118 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9037741 Fup 0.0188 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9037741 Vd NA 0.9158 L/kg 1compartment NA NA Rat Human +DTXSID9037741 Vd NA 0.8789 L/kg 1compartment NA NA Rat Human DTXSID9037741 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9037741 TK.Half.Life NA 1.212 hours 1compartment NA NA Rat Human -DTXSID9037741 Css NA 0.1132 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037741 Css NA 0.702 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037741 Css NA 0.06696 mg/L PBTK NA 50% Rat Human -DTXSID9037741 Css NA 0.4082 mg/L PBTK NA 95% Rat Human -DTXSID9037745 Clint NA 183.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037745 Fup NA 0.0122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037745 Vd NA 1.91 L/kg 1compartment NA NA Human Human -DTXSID9037745 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9037745 TK.Half.Life NA 4.618 hours 1compartment NA NA Human Human -DTXSID9037745 Css NA 0.261 mg/L 3compartmentss NA 50% Human Human -DTXSID9037745 Css NA 2.239 mg/L 3compartmentss NA 95% Human Human -DTXSID9037745 Css NA 0.1661 mg/L PBTK NA 50% Human Human -DTXSID9037745 Css NA 1.361 mg/L PBTK NA 95% Human Human -DTXSID9037745 Clint NA 183.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037745 Fup NA 0.0122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037745 Vd NA 1.415 L/kg 1compartment NA NA Rat Human +DTXSID9037741 TK.Half.Life NA 1.172 hours 1compartment NA NA Rat Human +DTXSID9037741 Css NA 0.02515 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037741 Css NA 0.166 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037741 Css NA 0.01538 mg/L PBTK NA 50% Rat Human +DTXSID9037741 Css NA 0.09884 mg/L PBTK NA 95% Rat Human +DTXSID9037745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037745 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037745 Vd NA 1.367 L/kg 1compartment NA NA Human Human +DTXSID9037745 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9037745 TK.Half.Life NA 14.48 hours 1compartment NA NA Human Human +DTXSID9037745 Css NA 1.675 mg/L 3compartmentss NA 50% Human Human +DTXSID9037745 Css NA 15.82 mg/L 3compartmentss NA 95% Human Human +DTXSID9037745 Css NA 1.037 mg/L PBTK NA 50% Human Human +DTXSID9037745 Css NA 9.394 mg/L PBTK NA 95% Human Human +DTXSID9037745 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037745 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037745 Vd NA 1.012 L/kg 1compartment NA NA Rat Human DTXSID9037745 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9037745 TK.Half.Life NA 1.538 hours 1compartment NA NA Rat Human -DTXSID9037745 Css NA 0.1466 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037745 Css NA 1.049 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037745 Css NA 0.08798 mg/L PBTK NA 50% Rat Human -DTXSID9037745 Css NA 0.5972 mg/L PBTK NA 95% Rat Human -DTXSID9037749 Clint NA 26.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037749 Fup NA 0.0234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9037749 Vd NA 2.326 L/kg 1compartment NA NA Human Human -DTXSID9037749 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9037749 TK.Half.Life NA 20 hours 1compartment NA NA Human Human -DTXSID9037749 Css NA 1.221 mg/L 3compartmentss NA 50% Human Human -DTXSID9037749 Css NA 9.462 mg/L 3compartmentss NA 95% Human Human -DTXSID9037749 Css NA 0.7996 mg/L PBTK NA 50% Human Human -DTXSID9037749 Css NA 5.836 mg/L PBTK NA 95% Human Human -DTXSID9037749 Clint NA 26.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037749 Fup NA 0.0234 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9037749 Vd NA 1.734 L/kg 1compartment NA NA Rat Human +DTXSID9037745 TK.Half.Life NA 5.796 hours 1compartment NA NA Rat Human +DTXSID9037745 Css NA 0.2196 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037745 Css NA 1.594 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037745 Css NA 0.1324 mg/L PBTK NA 50% Rat Human +DTXSID9037745 Css NA 0.9181 mg/L PBTK NA 95% Rat Human +DTXSID9037749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037749 Fup 0.012 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9037749 Vd NA 2.006 L/kg 1compartment NA NA Human Human +DTXSID9037749 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9037749 TK.Half.Life NA 28.23 hours 1compartment NA NA Human Human +DTXSID9037749 Css NA 2.133 mg/L 3compartmentss NA 50% Human Human +DTXSID9037749 Css NA 18.1 mg/L 3compartmentss NA 95% Human Human +DTXSID9037749 Css NA 1.368 mg/L PBTK NA 50% Human Human +DTXSID9037749 Css NA 10.8 mg/L PBTK NA 95% Human Human +DTXSID9037749 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037749 Fup 0.012 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9037749 Vd NA 1.487 L/kg 1compartment NA NA Rat Human DTXSID9037749 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9037749 TK.Half.Life NA 5.532 hours 1compartment NA NA Rat Human -DTXSID9037749 Css NA 0.6797 mg/L 3compartmentss NA 50% Rat Human -DTXSID9037749 Css NA 4.366 mg/L 3compartmentss NA 95% Rat Human -DTXSID9037749 Css NA 0.4226 mg/L PBTK NA 50% Rat Human -DTXSID9037749 Css NA 2.577 mg/L PBTK NA 95% Rat Human -DTXSID9038686 Clint NA 0.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9038686 Fup NA 0.0805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9038686 Vd NA 0.4005 L/kg 1compartment NA NA Human Human -DTXSID9038686 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9038686 TK.Half.Life NA 18.35 hours 1compartment NA NA Human Human -DTXSID9038686 Css NA 6.892 mg/L 3compartmentss NA 50% Human Human -DTXSID9038686 Css NA 34.8 mg/L 3compartmentss NA 95% Human Human -DTXSID9038686 Css NA 4.442 mg/L PBTK NA 50% Human Human -DTXSID9038686 Css NA 20.72 mg/L PBTK NA 95% Human Human -DTXSID9038686 Clint NA 0.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9038686 Fup NA 0.0805 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9038686 Vd NA 0.3925 L/kg 1compartment NA NA Rat Human +DTXSID9037749 TK.Half.Life NA 9.025 hours 1compartment NA NA Rat Human +DTXSID9037749 Css NA 0.2776 mg/L 3compartmentss NA 50% Rat Human +DTXSID9037749 Css NA 1.887 mg/L 3compartmentss NA 95% Rat Human +DTXSID9037749 Css NA 0.1733 mg/L PBTK NA 50% Rat Human +DTXSID9037749 Css NA 1.147 mg/L PBTK NA 95% Rat Human +DTXSID9038686 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9038686 Fup 0.0899 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9038686 Vd NA 0.4228 L/kg 1compartment NA NA Human Human +DTXSID9038686 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9038686 TK.Half.Life NA 1.168 hours 1compartment NA NA Human Human +DTXSID9038686 Css NA 0.3137 mg/L 3compartmentss NA 50% Human Human +DTXSID9038686 Css NA 2.594 mg/L 3compartmentss NA 95% Human Human +DTXSID9038686 Css NA 0.2027 mg/L PBTK NA 50% Human Human +DTXSID9038686 Css NA 1.598 mg/L PBTK NA 95% Human Human +DTXSID9038686 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9038686 Fup 0.0899 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9038686 Vd NA 0.4148 L/kg 1compartment NA NA Rat Human DTXSID9038686 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9038686 TK.Half.Life NA 7.861 hours 1compartment NA NA Rat Human -DTXSID9038686 Css NA 2.558 mg/L 3compartmentss NA 50% Rat Human -DTXSID9038686 Css NA 10.78 mg/L 3compartmentss NA 95% Rat Human -DTXSID9038686 Css NA 1.539 mg/L PBTK NA 50% Rat Human -DTXSID9038686 Css NA 5.999 mg/L PBTK NA 95% Rat Human -DTXSID9039238 Clint NA 4.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9039238 Fup NA 0.1922 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9039238 Vd NA 1.507 L/kg 1compartment NA NA Human Human +DTXSID9038686 TK.Half.Life NA 0.6911 hours 1compartment NA NA Rat Human +DTXSID9038686 Css NA 0.04061 mg/L 3compartmentss NA 50% Rat Human +DTXSID9038686 Css NA 0.2582 mg/L 3compartmentss NA 95% Rat Human +DTXSID9038686 Css NA 0.02554 mg/L PBTK NA 50% Rat Human +DTXSID9038686 Css NA 0.152 mg/L PBTK NA 95% Rat Human +DTXSID9039232 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9039232 Fup 0.802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9039232 Vd NA 0.9464 L/kg 1compartment NA NA Human Human +DTXSID9039232 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9039232 TK.Half.Life NA 7.76 hours 1compartment NA NA Human Human +DTXSID9039232 Css NA 0.9212 mg/L 3compartmentss NA 50% Human Human +DTXSID9039232 Css NA 5.905 mg/L 3compartmentss NA 95% Human Human +DTXSID9039232 Css NA 0.7959 mg/L PBTK NA 50% Human Human +DTXSID9039232 Css NA 3.818 mg/L PBTK NA 95% Human Human +DTXSID9039232 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9039232 Fup 0.802 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9039232 Vd NA 0.9322 L/kg 1compartment NA NA Rat Human +DTXSID9039232 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9039232 TK.Half.Life NA 2.572 hours 1compartment NA NA Rat Human +DTXSID9039232 Css NA 0.05446 mg/L 3compartmentss NA 50% Rat Human +DTXSID9039232 Css NA 0.3226 mg/L 3compartmentss NA 95% Rat Human +DTXSID9039232 Css NA 0.04743 mg/L PBTK NA 50% Rat Human +DTXSID9039232 Css NA 0.2039 mg/L PBTK NA 95% Rat Human +DTXSID9039238 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9039238 Fup 0.0767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9039238 Vd NA 0.953 L/kg 1compartment NA NA Human Human DTXSID9039238 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9039238 TK.Half.Life NA 8.778 hours 1compartment NA NA Human Human -DTXSID9039238 Css NA 0.6371 mg/L 3compartmentss NA 50% Human Human -DTXSID9039238 Css NA 3.306 mg/L 3compartmentss NA 95% Human Human -DTXSID9039238 Css NA 0.4544 mg/L PBTK NA 50% Human Human -DTXSID9039238 Css NA 2.169 mg/L PBTK NA 95% Human Human -DTXSID9039238 Clint NA 4.107 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9039238 Fup NA 0.1922 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9039238 Vd NA 1.185 L/kg 1compartment NA NA Rat Human +DTXSID9039238 TK.Half.Life NA 7.946 hours 1compartment NA NA Human Human +DTXSID9039238 Css NA 1.234 mg/L 3compartmentss NA 50% Human Human +DTXSID9039238 Css NA 8.142 mg/L 3compartmentss NA 95% Human Human +DTXSID9039238 Css NA 0.7816 mg/L PBTK NA 50% Human Human +DTXSID9039238 Css NA 4.912 mg/L PBTK NA 95% Human Human +DTXSID9039238 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9039238 Fup 0.0767 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9039238 Vd NA 0.7432 L/kg 1compartment NA NA Rat Human DTXSID9039238 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9039238 TK.Half.Life NA 3.375 hours 1compartment NA NA Rat Human -DTXSID9039238 Css NA 0.3151 mg/L 3compartmentss NA 50% Rat Human -DTXSID9039238 Css NA 1.181 mg/L 3compartmentss NA 95% Rat Human -DTXSID9039238 Css NA 0.2161 mg/L PBTK NA 50% Rat Human -DTXSID9039238 Css NA 0.7351 mg/L PBTK NA 95% Rat Human +DTXSID9039238 TK.Half.Life NA 3.531 hours 1compartment NA NA Rat Human +DTXSID9039238 Css NA 0.1518 mg/L 3compartmentss NA 50% Rat Human +DTXSID9039238 Css NA 0.735 mg/L 3compartmentss NA 95% Rat Human +DTXSID9039238 Css NA 0.09356 mg/L PBTK NA 50% Rat Human +DTXSID9039238 Css NA 0.4304 mg/L PBTK NA 95% Rat Human DTXSID9040001 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9040001 Fup 0.372 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9040001 Vd NA 0.4023 L/kg 1compartment NA NA Human Human DTXSID9040001 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9040001 TK.Half.Life NA 6.999 hours 1compartment NA NA Human Human -DTXSID9040001 Css NA 1.818 mg/L 3compartmentss NA 50% Human Human -DTXSID9040001 Css NA 5.797 mg/L 3compartmentss NA 95% Human Human -DTXSID9040001 Css NA 1.279 mg/L PBTK NA 50% Human Human -DTXSID9040001 Css NA 3.74 mg/L PBTK NA 95% Human Human +DTXSID9040001 Css NA 1.278 mg/L 3compartmentss NA 50% Human Human +DTXSID9040001 Css NA 4.384 mg/L 3compartmentss NA 95% Human Human +DTXSID9040001 Css NA 0.9066 mg/L PBTK NA 50% Human Human +DTXSID9040001 Css NA 2.821 mg/L PBTK NA 95% Human Human DTXSID9040001 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9040001 Fup 0.372 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9040001 Vd NA 0.4045 L/kg 1compartment NA NA Rat Human DTXSID9040001 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9040001 TK.Half.Life NA 2.398 hours 1compartment NA NA Rat Human -DTXSID9040001 Css NA 0.5166 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040001 Css NA 1.319 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040001 Css NA 0.3478 mg/L PBTK NA 50% Rat Human -DTXSID9040001 Css NA 0.7898 mg/L PBTK NA 95% Rat Human -DTXSID9040130 Clint NA 12.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9040001 Css NA 0.01065 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040001 Css NA 0.06058 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040001 Css NA 0.007138 mg/L PBTK NA 50% Rat Human +DTXSID9040001 Css NA 0.03982 mg/L PBTK NA 95% Rat Human +DTXSID9040130 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9040130 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9040130 Vd NA 2.26 L/kg 1compartment NA NA Human Human DTXSID9040130 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040130 TK.Half.Life NA 4.881 hours 1compartment NA NA Human Human -DTXSID9040130 Css NA 0.1608 mg/L 3compartmentss NA 50% Human Human -DTXSID9040130 Css NA 1.074 mg/L 3compartmentss NA 95% Human Human -DTXSID9040130 Css NA 0.137 mg/L PBTK NA 50% Human Human -DTXSID9040130 Css NA 0.7993 mg/L PBTK NA 95% Human Human -DTXSID9040130 Clint NA 12.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9040130 TK.Half.Life NA 8.042 hours 1compartment NA NA Human Human +DTXSID9040130 Css NA 0.301 mg/L 3compartmentss NA 50% Human Human +DTXSID9040130 Css NA 1.858 mg/L 3compartmentss NA 95% Human Human +DTXSID9040130 Css NA 0.2548 mg/L PBTK NA 50% Human Human +DTXSID9040130 Css NA 1.39 mg/L PBTK NA 95% Human Human +DTXSID9040130 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9040130 Fup 0.2 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9040130 Vd NA 2.094 L/kg 1compartment NA NA Rat Human DTXSID9040130 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040130 TK.Half.Life NA 2.427 hours 1compartment NA NA Rat Human -DTXSID9040130 Css NA 0.08541 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040130 Css NA 0.4374 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040130 Css NA 0.07081 mg/L PBTK NA 50% Rat Human -DTXSID9040130 Css NA 0.3134 mg/L PBTK NA 95% Rat Human -DTXSID9040134 Clint NA 5.365 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040134 Fup NA 0.209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040134 Vd NA 2.105 L/kg 1compartment NA NA Human Human +DTXSID9040130 TK.Half.Life NA 4.002 hours 1compartment NA NA Rat Human +DTXSID9040130 Css NA 0.03504 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040130 Css NA 0.1608 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040130 Css NA 0.03024 mg/L PBTK NA 50% Rat Human +DTXSID9040130 Css NA 0.1179 mg/L PBTK NA 95% Rat Human +DTXSID9040132 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040132 Fup 0.93 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9040132 Vd NA 0.6078 L/kg 1compartment NA NA Human Human +DTXSID9040132 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9040132 TK.Half.Life NA 4.229 hours 1compartment NA NA Human Human +DTXSID9040132 Css NA 0.7832 mg/L 3compartmentss NA 50% Human Human +DTXSID9040132 Css NA 2.8 mg/L 3compartmentss NA 95% Human Human +DTXSID9040132 Css NA 0.6274 mg/L PBTK NA 50% Human Human +DTXSID9040132 Css NA 1.932 mg/L PBTK NA 95% Human Human +DTXSID9040132 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040132 Fup 0.93 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9040132 Vd NA 0.6338 L/kg 1compartment NA NA Rat Human +DTXSID9040132 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9040132 TK.Half.Life NA 1.503 hours 1compartment NA NA Rat Human +DTXSID9040132 Css NA 0.01938 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040132 Css NA 0.09169 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040132 Css NA 0.01506 mg/L PBTK NA 50% Rat Human +DTXSID9040132 Css NA 0.06336 mg/L PBTK NA 95% Rat Human +DTXSID9040134 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040134 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040134 Vd NA 2.31 L/kg 1compartment NA NA Human Human DTXSID9040134 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040134 TK.Half.Life NA 11.25 hours 1compartment NA NA Human Human -DTXSID9040134 Css NA 0.5612 mg/L 3compartmentss NA 50% Human Human -DTXSID9040134 Css NA 2.914 mg/L 3compartmentss NA 95% Human Human -DTXSID9040134 Css NA 0.4173 mg/L PBTK NA 50% Human Human -DTXSID9040134 Css NA 2.072 mg/L PBTK NA 95% Human Human -DTXSID9040134 Clint NA 5.365 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040134 Fup NA 0.209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040134 Vd NA 1.66 L/kg 1compartment NA NA Rat Human +DTXSID9040134 TK.Half.Life NA 3.952 hours 1compartment NA NA Human Human +DTXSID9040134 Css NA 0.1132 mg/L 3compartmentss NA 50% Human Human +DTXSID9040134 Css NA 0.7957 mg/L 3compartmentss NA 95% Human Human +DTXSID9040134 Css NA 0.08726 mg/L PBTK NA 50% Human Human +DTXSID9040134 Css NA 0.5642 mg/L PBTK NA 95% Human Human +DTXSID9040134 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040134 Fup 0.286 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040134 Vd NA 1.833 L/kg 1compartment NA NA Rat Human DTXSID9040134 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040134 TK.Half.Life NA 3.767 hours 1compartment NA NA Rat Human -DTXSID9040134 Css NA 0.2846 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040134 Css NA 1.093 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040134 Css NA 0.2032 mg/L PBTK NA 50% Rat Human -DTXSID9040134 Css NA 0.7182 mg/L PBTK NA 95% Rat Human +DTXSID9040134 TK.Half.Life NA 1.324 hours 1compartment NA NA Rat Human +DTXSID9040134 Css NA 0.01422 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040134 Css NA 0.07277 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040134 Css NA 0.01099 mg/L PBTK NA 50% Rat Human +DTXSID9040134 Css NA 0.05239 mg/L PBTK NA 95% Rat Human DTXSID9040215 Clint 0.4575 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID9040215 Fup NA 0.9402 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040215 Vd NA 0.5909 L/kg 1compartment NA NA Human Human +DTXSID9040215 Fup 0.868 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040215 Vd NA 0.4948 L/kg 1compartment NA NA Human Human DTXSID9040215 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040215 TK.Half.Life NA 2.385 hours 1compartment NA NA Human Human -DTXSID9040215 Css NA 0.5194 mg/L 3compartmentss NA 50% Human Human -DTXSID9040215 Css NA 1.903 mg/L 3compartmentss NA 95% Human Human -DTXSID9040215 Css NA 0.4012 mg/L PBTK NA 50% Human Human -DTXSID9040215 Css NA 1.287 mg/L PBTK NA 95% Human Human +DTXSID9040215 TK.Half.Life NA 2.135 hours 1compartment NA NA Human Human +DTXSID9040215 Css NA 0.3112 mg/L 3compartmentss NA 50% Human Human +DTXSID9040215 Css NA 1.909 mg/L 3compartmentss NA 95% Human Human +DTXSID9040215 Css NA 0.2304 mg/L PBTK NA 50% Human Human +DTXSID9040215 Css NA 1.214 mg/L PBTK NA 95% Human Human DTXSID9040215 Clint 0.4575 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID9040215 Fup NA 0.9402 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040215 Vd NA 0.6118 L/kg 1compartment NA NA Rat Human +DTXSID9040215 Fup 0.868 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040215 Vd NA 0.5245 L/kg 1compartment NA NA Rat Human DTXSID9040215 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040215 TK.Half.Life NA 1.062 hours 1compartment NA NA Rat Human -DTXSID9040215 Css NA 0.1734 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040215 Css NA 0.5484 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040215 Css NA 0.131 mg/L PBTK NA 50% Rat Human -DTXSID9040215 Css NA 0.344 mg/L PBTK NA 95% Rat Human -DTXSID9040265 Clint NA 48.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040265 Fup NA 0.0426 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040265 Vd NA 2.862 L/kg 1compartment NA NA Human Human -DTXSID9040265 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9040265 TK.Half.Life NA 16.18 hours 1compartment NA NA Human Human -DTXSID9040265 Css NA 0.6681 mg/L 3compartmentss NA 50% Human Human -DTXSID9040265 Css NA 4.412 mg/L 3compartmentss NA 95% Human Human -DTXSID9040265 Css NA 0.4576 mg/L PBTK NA 50% Human Human -DTXSID9040265 Css NA 2.925 mg/L PBTK NA 95% Human Human -DTXSID9040265 Clint NA 48.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040265 Fup NA 0.0426 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040265 Vd NA 2.144 L/kg 1compartment NA NA Rat Human -DTXSID9040265 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040265 TK.Half.Life NA 3.254 hours 1compartment NA NA Rat Human -DTXSID9040265 Css NA 0.3732 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040265 Css NA 1.993 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040265 Css NA 0.2431 mg/L PBTK NA 50% Rat Human -DTXSID9040265 Css NA 1.262 mg/L PBTK NA 95% Rat Human -DTXSID9040269 Clint NA 116.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040269 Fup NA 0.0529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040269 Vd NA 1.336 L/kg 1compartment NA NA Human Human +DTXSID9040215 TK.Half.Life NA 0.9781 hours 1compartment NA NA Rat Human +DTXSID9040215 Css NA 0.002075 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040215 Css NA 0.01274 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040215 Css NA 0.001493 mg/L PBTK NA 50% Rat Human +DTXSID9040215 Css NA 0.007643 mg/L PBTK NA 95% Rat Human +DTXSID9040265 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040265 Fup 0.0219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040265 Vd NA 2.639 L/kg 1compartment NA NA Human Human +DTXSID9040265 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9040265 TK.Half.Life NA 34.11 hours 1compartment NA NA Human Human +DTXSID9040265 Css NA 1.739 mg/L 3compartmentss NA 50% Human Human +DTXSID9040265 Css NA 13.03 mg/L 3compartmentss NA 95% Human Human +DTXSID9040265 Css NA 1.162 mg/L PBTK NA 50% Human Human +DTXSID9040265 Css NA 8.228 mg/L PBTK NA 95% Human Human +DTXSID9040265 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040265 Fup 0.0219 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040265 Vd NA 1.971 L/kg 1compartment NA NA Rat Human +DTXSID9040265 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9040265 TK.Half.Life NA 7.667 hours 1compartment NA NA Rat Human +DTXSID9040265 Css NA 0.2246 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040265 Css NA 1.347 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040265 Css NA 0.1474 mg/L PBTK NA 50% Rat Human +DTXSID9040265 Css NA 0.8734 mg/L PBTK NA 95% Rat Human +DTXSID9040269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040269 Fup 0.0153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040269 Vd NA 0.4447 L/kg 1compartment NA NA Human Human DTXSID9040269 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040269 TK.Half.Life NA 2.041 hours 1compartment NA NA Human Human -DTXSID9040269 Css NA 0.1137 mg/L 3compartmentss NA 50% Human Human -DTXSID9040269 Css NA 0.8941 mg/L 3compartmentss NA 95% Human Human -DTXSID9040269 Css NA 0.07327 mg/L PBTK NA 50% Human Human -DTXSID9040269 Css NA 0.5526 mg/L PBTK NA 95% Human Human -DTXSID9040269 Clint NA 116.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040269 Fup NA 0.0529 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040269 Vd NA 1.009 L/kg 1compartment NA NA Rat Human +DTXSID9040269 TK.Half.Life NA 5.063 hours 1compartment NA NA Human Human +DTXSID9040269 Css NA 1.914 mg/L 3compartmentss NA 50% Human Human +DTXSID9040269 Css NA 19.38 mg/L 3compartmentss NA 95% Human Human +DTXSID9040269 Css NA 1.142 mg/L PBTK NA 50% Human Human +DTXSID9040269 Css NA 11.3 mg/L PBTK NA 95% Human Human +DTXSID9040269 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040269 Fup 0.0153 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040269 Vd NA 0.3496 L/kg 1compartment NA NA Rat Human DTXSID9040269 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040269 TK.Half.Life NA 0.7609 hours 1compartment NA NA Rat Human -DTXSID9040269 Css NA 0.06335 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040269 Css NA 0.4287 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040269 Css NA 0.03856 mg/L PBTK NA 50% Rat Human -DTXSID9040269 Css NA 0.2485 mg/L PBTK NA 95% Rat Human -DTXSID9040342 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040342 Fup NA 0.8494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040342 Vd NA 0.8617 L/kg 1compartment NA NA Human Human +DTXSID9040269 TK.Half.Life NA 2.583 hours 1compartment NA NA Rat Human +DTXSID9040269 Css NA 0.252 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040269 Css NA 2.016 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040269 Css NA 0.1446 mg/L PBTK NA 50% Rat Human +DTXSID9040269 Css NA 1.133 mg/L PBTK NA 95% Rat Human +DTXSID9040342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040342 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040342 Vd NA 0.8409 L/kg 1compartment NA NA Human Human DTXSID9040342 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040342 TK.Half.Life NA 6.608 hours 1compartment NA NA Human Human -DTXSID9040342 Css NA 0.9317 mg/L 3compartmentss NA 50% Human Human -DTXSID9040342 Css NA 5.573 mg/L 3compartmentss NA 95% Human Human -DTXSID9040342 Css NA 0.7916 mg/L PBTK NA 50% Human Human -DTXSID9040342 Css NA 3.68 mg/L PBTK NA 95% Human Human -DTXSID9040342 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040342 Fup NA 0.8494 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040342 Vd NA 0.8716 L/kg 1compartment NA NA Rat Human +DTXSID9040342 TK.Half.Life NA 0.6856 hours 1compartment NA NA Human Human +DTXSID9040342 Css NA 0.0223 mg/L 3compartmentss NA 50% Human Human +DTXSID9040342 Css NA 0.2556 mg/L 3compartmentss NA 95% Human Human +DTXSID9040342 Css NA 0.01838 mg/L PBTK NA 50% Human Human +DTXSID9040342 Css NA 0.1797 mg/L PBTK NA 95% Human Human +DTXSID9040342 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040342 Fup 0.722 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040342 Vd NA 0.8374 L/kg 1compartment NA NA Rat Human DTXSID9040342 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040342 TK.Half.Life NA 2.266 hours 1compartment NA NA Rat Human -DTXSID9040342 Css NA 0.2365 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040342 Css NA 1.431 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040342 Css NA 0.196 mg/L PBTK NA 50% Rat Human -DTXSID9040342 Css NA 0.8662 mg/L PBTK NA 95% Rat Human -DTXSID9040502 Clint NA 35.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040502 Fup NA 0.0414 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040502 Vd NA 2.156 L/kg 1compartment NA NA Human Human +DTXSID9040342 TK.Half.Life NA 0.3336 hours 1compartment NA NA Rat Human +DTXSID9040342 Css NA 0.0007956 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040342 Css NA 0.00996 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040342 Css NA 0.0006428 mg/L PBTK NA 50% Rat Human +DTXSID9040342 Css NA 0.006789 mg/L PBTK NA 95% Rat Human +DTXSID9040502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040502 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040502 Vd NA 0.557 L/kg 1compartment NA NA Human Human DTXSID9040502 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040502 TK.Half.Life NA 5.056 hours 1compartment NA NA Human Human -DTXSID9040502 Css NA 0.2526 mg/L 3compartmentss NA 50% Human Human -DTXSID9040502 Css NA 2.33 mg/L 3compartmentss NA 95% Human Human -DTXSID9040502 Css NA 0.182 mg/L PBTK NA 50% Human Human -DTXSID9040502 Css NA 1.54 mg/L PBTK NA 95% Human Human -DTXSID9040502 Clint NA 35.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040502 Fup NA 0.0414 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040502 Vd NA 1.89 L/kg 1compartment NA NA Rat Human +DTXSID9040502 TK.Half.Life NA 1.118 hours 1compartment NA NA Human Human +DTXSID9040502 Css NA 0.1536 mg/L 3compartmentss NA 50% Human Human +DTXSID9040502 Css NA 1.321 mg/L 3compartmentss NA 95% Human Human +DTXSID9040502 Css NA 0.1002 mg/L PBTK NA 50% Human Human +DTXSID9040502 Css NA 0.8081 mg/L PBTK NA 95% Human Human +DTXSID9040502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040502 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040502 Vd NA 0.5612 L/kg 1compartment NA NA Rat Human DTXSID9040502 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040502 TK.Half.Life NA 2.315 hours 1compartment NA NA Rat Human -DTXSID9040502 Css NA 0.1391 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040502 Css NA 1.084 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040502 Css NA 0.09493 mg/L PBTK NA 50% Rat Human -DTXSID9040502 Css NA 0.6676 mg/L PBTK NA 95% Rat Human +DTXSID9040502 TK.Half.Life NA 0.6472 hours 1compartment NA NA Rat Human +DTXSID9040502 Css NA 0.007508 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040502 Css NA 0.0709 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040502 Css NA 0.004756 mg/L PBTK NA 50% Rat Human +DTXSID9040502 Css NA 0.04199 mg/L PBTK NA 95% Rat Human DTXSID9040554 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Human Human DTXSID9040554 Fup 0.77 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9040554 Vd NA 1.587 L/kg 1compartment NA NA Human Human +DTXSID9040554 Vd NA 1.841 L/kg 1compartment NA NA Human Human DTXSID9040554 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040554 TK.Half.Life NA 2.974 hours 1compartment NA NA Human Human -DTXSID9040554 Css NA 0.1633 mg/L 3compartmentss NA 50% Human Human -DTXSID9040554 Css NA 1.281 mg/L 3compartmentss NA 95% Human Human -DTXSID9040554 Css NA 0.1514 mg/L PBTK NA 50% Human Human -DTXSID9040554 Css NA 0.9209 mg/L PBTK NA 95% Human Human +DTXSID9040554 TK.Half.Life NA 3.61 hours 1compartment NA NA Human Human +DTXSID9040554 Css NA 0.1582 mg/L 3compartmentss NA 50% Human Human +DTXSID9040554 Css NA 1.233 mg/L 3compartmentss NA 95% Human Human +DTXSID9040554 Css NA 0.1498 mg/L PBTK NA 50% Human Human +DTXSID9040554 Css NA 0.8882 mg/L PBTK NA 95% Human Human DTXSID9040554 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077396 NA Rat Human DTXSID9040554 Fup 0.77 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9040554 Vd NA 1.494 L/kg 1compartment NA NA Rat Human +DTXSID9040554 Vd NA 1.683 L/kg 1compartment NA NA Rat Human DTXSID9040554 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040554 TK.Half.Life NA 1.436 hours 1compartment NA NA Rat Human -DTXSID9040554 Css NA 0.07148 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040554 Css NA 0.5504 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040554 Css NA 0.06576 mg/L PBTK NA 50% Rat Human -DTXSID9040554 Css NA 0.3474 mg/L PBTK NA 95% Rat Human +DTXSID9040554 TK.Half.Life NA 1.629 hours 1compartment NA NA Rat Human +DTXSID9040554 Css NA 0.01628 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040554 Css NA 0.1202 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040554 Css NA 0.01584 mg/L PBTK NA 50% Rat Human +DTXSID9040554 Css NA 0.08115 mg/L PBTK NA 95% Rat Human +DTXSID9040556 Clint 25 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID9040556 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9040556 Vd NA 1.501 L/kg 1compartment NA NA Human Human +DTXSID9040556 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9040556 TK.Half.Life NA 6.876 hours 1compartment NA NA Human Human +DTXSID9040556 Css NA 0.3752 mg/L 3compartmentss NA 50% Human Human +DTXSID9040556 Css NA 3.533 mg/L 3compartmentss NA 95% Human Human +DTXSID9040556 Css NA 0.4502 mg/L PBTK NA 50% Human Human +DTXSID9040556 Css NA 4.239 mg/L PBTK NA 95% Human Human DTXSID9040556 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID9040556 Fup 0.02 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID9040556 Vd NA 1.289 L/kg 1compartment NA NA Rat Rat DTXSID9040556 Days.Css NA 39 Days PBTK NA NA Rat Rat DTXSID9040556 TK.Half.Life NA 148.1 hours 1compartment NA NA Rat Rat -DTXSID9040556 Css NA 10.14 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9040556 Css NA 74.01 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9040556 Css NA 9.98 mg/L PBTK NA 50% Rat Rat -DTXSID9040556 Css NA 46.96 mg/L PBTK NA 95% Rat Rat -DTXSID9040635 Clint NA 2.928 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040635 Fup NA 0.2765 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040635 Vd NA 0.8852 L/kg 1compartment NA NA Human Human +DTXSID9040556 Css NA 1.86 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9040556 Css NA 8.689 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9040556 Css NA 2.312 mg/L PBTK NA 50% Rat Rat +DTXSID9040556 Css NA 10.8 mg/L PBTK NA 95% Rat Rat +DTXSID9040635 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040635 Fup 0.304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040635 Vd NA 0.9335 L/kg 1compartment NA NA Human Human DTXSID9040635 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040635 TK.Half.Life NA 4.121 hours 1compartment NA NA Human Human -DTXSID9040635 Css NA 0.4872 mg/L 3compartmentss NA 50% Human Human -DTXSID9040635 Css NA 2.599 mg/L 3compartmentss NA 95% Human Human -DTXSID9040635 Css NA 0.355 mg/L PBTK NA 50% Human Human -DTXSID9040635 Css NA 1.702 mg/L PBTK NA 95% Human Human -DTXSID9040635 Clint NA 2.928 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040635 Fup NA 0.2765 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040635 Vd NA 0.7708 L/kg 1compartment NA NA Rat Human +DTXSID9040635 TK.Half.Life NA 2.389 hours 1compartment NA NA Human Human +DTXSID9040635 Css NA 0.2198 mg/L 3compartmentss NA 50% Human Human +DTXSID9040635 Css NA 1.398 mg/L 3compartmentss NA 95% Human Human +DTXSID9040635 Css NA 0.1622 mg/L PBTK NA 50% Human Human +DTXSID9040635 Css NA 0.9443 mg/L PBTK NA 95% Human Human +DTXSID9040635 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040635 Fup 0.304 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040635 Vd NA 0.8134 L/kg 1compartment NA NA Rat Human DTXSID9040635 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040635 TK.Half.Life NA 1.942 hours 1compartment NA NA Rat Human -DTXSID9040635 Css NA 0.2334 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040635 Css NA 0.8958 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040635 Css NA 0.1623 mg/L PBTK NA 50% Rat Human -DTXSID9040635 Css NA 0.5478 mg/L PBTK NA 95% Rat Human -DTXSID9040683 Clint NA 26.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040683 Fup NA 0.0658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040683 Vd NA 2.026 L/kg 1compartment NA NA Human Human +DTXSID9040635 TK.Half.Life NA 1.15 hours 1compartment NA NA Rat Human +DTXSID9040635 Css NA 0.02618 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040635 Css NA 0.1183 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040635 Css NA 0.01918 mg/L PBTK NA 50% Rat Human +DTXSID9040635 Css NA 0.07623 mg/L PBTK NA 95% Rat Human +DTXSID9040683 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040683 Fup 0.0477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040683 Vd NA 1.734 L/kg 1compartment NA NA Human Human DTXSID9040683 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040683 TK.Half.Life NA 7.832 hours 1compartment NA NA Human Human -DTXSID9040683 Css NA 0.4641 mg/L 3compartmentss NA 50% Human Human -DTXSID9040683 Css NA 3.112 mg/L 3compartmentss NA 95% Human Human -DTXSID9040683 Css NA 0.3066 mg/L PBTK NA 50% Human Human -DTXSID9040683 Css NA 1.979 mg/L PBTK NA 95% Human Human -DTXSID9040683 Clint NA 26.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040683 Fup NA 0.0658 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040683 Vd NA 1.523 L/kg 1compartment NA NA Rat Human +DTXSID9040683 TK.Half.Life NA 8.923 hours 1compartment NA NA Human Human +DTXSID9040683 Css NA 0.6888 mg/L 3compartmentss NA 50% Human Human +DTXSID9040683 Css NA 5.301 mg/L 3compartmentss NA 95% Human Human +DTXSID9040683 Css NA 0.4449 mg/L PBTK NA 50% Human Human +DTXSID9040683 Css NA 3.318 mg/L PBTK NA 95% Human Human +DTXSID9040683 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040683 Fup 0.0477 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040683 Vd NA 1.3 L/kg 1compartment NA NA Rat Human DTXSID9040683 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040683 TK.Half.Life NA 2.55 hours 1compartment NA NA Rat Human -DTXSID9040683 Css NA 0.2579 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040683 Css NA 1.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040683 Css NA 0.1624 mg/L PBTK NA 50% Rat Human -DTXSID9040683 Css NA 0.8514 mg/L PBTK NA 95% Rat Human -DTXSID9040685 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9040683 TK.Half.Life NA 3.205 hours 1compartment NA NA Rat Human +DTXSID9040683 Css NA 0.08886 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040683 Css NA 0.5419 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040683 Css NA 0.05609 mg/L PBTK NA 50% Rat Human +DTXSID9040683 Css NA 0.3299 mg/L PBTK NA 95% Rat Human +DTXSID9040685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9040685 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9040685 Vd NA 1.613 L/kg 1compartment NA NA Human Human -DTXSID9040685 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9040685 TK.Half.Life NA 11.74 hours 1compartment NA NA Human Human -DTXSID9040685 Css NA 0.729 mg/L 3compartmentss NA 50% Human Human -DTXSID9040685 Css NA 5.402 mg/L 3compartmentss NA 95% Human Human -DTXSID9040685 Css NA 0.7126 mg/L PBTK NA 50% Human Human -DTXSID9040685 Css NA 3.599 mg/L PBTK NA 95% Human Human -DTXSID9040685 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9040685 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9040685 TK.Half.Life NA 1.067 hours 1compartment NA NA Human Human +DTXSID9040685 Css NA 0.0188 mg/L 3compartmentss NA 50% Human Human +DTXSID9040685 Css NA 0.2577 mg/L 3compartmentss NA 95% Human Human +DTXSID9040685 Css NA 0.0179 mg/L PBTK NA 50% Human Human +DTXSID9040685 Css NA 0.2033 mg/L PBTK NA 95% Human Human +DTXSID9040685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9040685 Fup 1 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9040685 Vd NA 1.479 L/kg 1compartment NA NA Rat Human DTXSID9040685 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040685 TK.Half.Life NA 3.358 hours 1compartment NA NA Rat Human -DTXSID9040685 Css NA 0.1859 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040685 Css NA 1.239 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040685 Css NA 0.1797 mg/L PBTK NA 50% Rat Human -DTXSID9040685 Css NA 0.7896 mg/L PBTK NA 95% Rat Human -DTXSID9040687 Clint NA 4.373 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9040685 TK.Half.Life NA 0.459 hours 1compartment NA NA Rat Human +DTXSID9040685 Css NA 0.002186 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040685 Css NA 0.02284 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040685 Css NA 0.002172 mg/L PBTK NA 50% Rat Human +DTXSID9040685 Css NA 0.01879 mg/L PBTK NA 95% Rat Human +DTXSID9040687 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID9040687 Fup 0.029 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9040687 Vd NA 0.2976 L/kg 1compartment NA NA Human Human +DTXSID9040687 Vd NA 0.2755 L/kg 1compartment NA NA Human Human DTXSID9040687 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040687 TK.Half.Life NA 8.121 hours 1compartment NA NA Human Human -DTXSID9040687 Css NA 4.885 mg/L 3compartmentss NA 50% Human Human -DTXSID9040687 Css NA 39.21 mg/L 3compartmentss NA 95% Human Human -DTXSID9040687 Css NA 2.968 mg/L PBTK NA 50% Human Human -DTXSID9040687 Css NA 23.02 mg/L PBTK NA 95% Human Human -DTXSID9040687 Clint NA 4.373 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9040687 TK.Half.Life NA 6.736 hours 1compartment NA NA Human Human +DTXSID9040687 Css NA 4.287 mg/L 3compartmentss NA 50% Human Human +DTXSID9040687 Css NA 35.09 mg/L 3compartmentss NA 95% Human Human +DTXSID9040687 Css NA 2.601 mg/L PBTK NA 50% Human Human +DTXSID9040687 Css NA 20.38 mg/L PBTK NA 95% Human Human +DTXSID9040687 Clint 5 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID9040687 Fup 0.029 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9040687 Vd NA 0.2767 L/kg 1compartment NA NA Rat Human +DTXSID9040687 Vd NA 0.2596 L/kg 1compartment NA NA Rat Human DTXSID9040687 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040687 TK.Half.Life NA 4.643 hours 1compartment NA NA Rat Human -DTXSID9040687 Css NA 2.526 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040687 Css NA 15.77 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040687 Css NA 1.432 mg/L PBTK NA 50% Rat Human -DTXSID9040687 Css NA 8.613 mg/L PBTK NA 95% Rat Human -DTXSID9040712 Clint NA 72.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040712 Fup NA 0.0764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040712 Vd NA 3.133 L/kg 1compartment NA NA Human Human -DTXSID9040712 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9040712 TK.Half.Life NA 28.76 hours 1compartment NA NA Human Human -DTXSID9040712 Css NA 1.032 mg/L 3compartmentss NA 50% Human Human -DTXSID9040712 Css NA 6.149 mg/L 3compartmentss NA 95% Human Human -DTXSID9040712 Css NA 0.7175 mg/L PBTK NA 50% Human Human -DTXSID9040712 Css NA 4.225 mg/L PBTK NA 95% Human Human -DTXSID9040712 Clint NA 72.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040712 Fup NA 0.0764 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040712 Vd NA 2.348 L/kg 1compartment NA NA Rat Human -DTXSID9040712 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9040712 TK.Half.Life NA 4.156 hours 1compartment NA NA Rat Human -DTXSID9040712 Css NA 0.5851 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040712 Css NA 2.818 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040712 Css NA 0.3902 mg/L PBTK NA 50% Rat Human -DTXSID9040712 Css NA 1.815 mg/L PBTK NA 95% Rat Human -DTXSID9040714 Clint NA 1.982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040714 Fup NA 0.1971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040714 Vd NA 1.294 L/kg 1compartment NA NA Human Human -DTXSID9040714 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9040714 TK.Half.Life NA 11.93 hours 1compartment NA NA Human Human -DTXSID9040714 Css NA 1.063 mg/L 3compartmentss NA 50% Human Human -DTXSID9040714 Css NA 4.772 mg/L 3compartmentss NA 95% Human Human -DTXSID9040714 Css NA 0.7572 mg/L PBTK NA 50% Human Human -DTXSID9040714 Css NA 3.087 mg/L PBTK NA 95% Human Human -DTXSID9040714 Clint NA 1.982 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040714 Fup NA 0.1971 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040714 Vd NA 1.035 L/kg 1compartment NA NA Rat Human +DTXSID9040687 TK.Half.Life NA 3.945 hours 1compartment NA NA Rat Human +DTXSID9040687 Css NA 0.5163 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040687 Css NA 3.287 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040687 Css NA 0.3016 mg/L PBTK NA 50% Rat Human +DTXSID9040687 Css NA 1.854 mg/L PBTK NA 95% Rat Human +DTXSID9040714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040714 Fup 0.0919 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040714 Vd NA 1.152 L/kg 1compartment NA NA Human Human +DTXSID9040714 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9040714 TK.Half.Life NA 3.27 hours 1compartment NA NA Human Human +DTXSID9040714 Css NA 0.3188 mg/L 3compartmentss NA 50% Human Human +DTXSID9040714 Css NA 2.394 mg/L 3compartmentss NA 95% Human Human +DTXSID9040714 Css NA 0.2064 mg/L PBTK NA 50% Human Human +DTXSID9040714 Css NA 1.502 mg/L PBTK NA 95% Human Human +DTXSID9040714 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040714 Fup 0.0919 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040714 Vd NA 0.8933 L/kg 1compartment NA NA Rat Human DTXSID9040714 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040714 TK.Half.Life NA 4.584 hours 1compartment NA NA Rat Human -DTXSID9040714 Css NA 0.482 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040714 Css NA 1.593 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040714 Css NA 0.3282 mg/L PBTK NA 50% Rat Human -DTXSID9040714 Css NA 0.9611 mg/L PBTK NA 95% Rat Human -DTXSID9040716 Clint NA 0.4202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040716 Fup NA 0.1435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040716 Vd NA 2.636 L/kg 1compartment NA NA Human Human -DTXSID9040716 Days.Css NA 46 Days PBTK NA NA Human Human -DTXSID9040716 TK.Half.Life NA 220.2 hours 1compartment NA NA Human Human -DTXSID9040716 Css NA 10.14 mg/L 3compartmentss NA 50% Human Human -DTXSID9040716 Css NA 33.85 mg/L 3compartmentss NA 95% Human Human -DTXSID9040716 Css NA 7.185 mg/L PBTK NA 50% Human Human -DTXSID9040716 Css NA 22.14 mg/L PBTK NA 95% Human Human -DTXSID9040716 Clint NA 0.4202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040716 Fup NA 0.1435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040716 Vd NA 1.993 L/kg 1compartment NA NA Rat Human -DTXSID9040716 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID9040716 TK.Half.Life NA 33.88 hours 1compartment NA NA Rat Human -DTXSID9040716 Css NA 3.822 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040716 Css NA 9.816 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040716 Css NA 2.574 mg/L PBTK NA 50% Rat Human -DTXSID9040716 Css NA 5.914 mg/L PBTK NA 95% Rat Human -DTXSID9040718 Clint NA 220.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040718 Fup NA 0.2732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9040718 Vd NA 0.8784 L/kg 1compartment NA NA Human Human -DTXSID9040718 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9040718 TK.Half.Life NA 0.7202 hours 1compartment NA NA Human Human -DTXSID9040718 Css NA 0.008126 mg/L 3compartmentss NA 50% Human Human -DTXSID9040718 Css NA 0.06355 mg/L 3compartmentss NA 95% Human Human -DTXSID9040718 Css NA 0.00588 mg/L PBTK NA 50% Human Human -DTXSID9040718 Css NA 0.04273 mg/L PBTK NA 95% Human Human -DTXSID9040718 Clint NA 220.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040718 Fup NA 0.2732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9040718 Vd NA 0.7642 L/kg 1compartment NA NA Rat Human -DTXSID9040718 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9040718 TK.Half.Life NA 0.2825 hours 1compartment NA NA Rat Human -DTXSID9040718 Css NA 0.004457 mg/L 3compartmentss NA 50% Rat Human -DTXSID9040718 Css NA 0.02851 mg/L 3compartmentss NA 95% Rat Human -DTXSID9040718 Css NA 0.0031 mg/L PBTK NA 50% Rat Human -DTXSID9040718 Css NA 0.01856 mg/L PBTK NA 95% Rat Human +DTXSID9040714 TK.Half.Life NA 1.382 hours 1compartment NA NA Rat Human +DTXSID9040714 Css NA 0.04093 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040714 Css NA 0.2627 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040714 Css NA 0.02599 mg/L PBTK NA 50% Rat Human +DTXSID9040714 Css NA 0.1583 mg/L PBTK NA 95% Rat Human +DTXSID9040716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040716 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040716 Vd NA 2.342 L/kg 1compartment NA NA Human Human +DTXSID9040716 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9040716 TK.Half.Life NA 8.621 hours 1compartment NA NA Human Human +DTXSID9040716 Css NA 0.3964 mg/L 3compartmentss NA 50% Human Human +DTXSID9040716 Css NA 2.722 mg/L 3compartmentss NA 95% Human Human +DTXSID9040716 Css NA 0.2739 mg/L PBTK NA 50% Human Human +DTXSID9040716 Css NA 1.771 mg/L PBTK NA 95% Human Human +DTXSID9040716 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040716 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040716 Vd NA 1.77 L/kg 1compartment NA NA Rat Human +DTXSID9040716 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9040716 TK.Half.Life NA 2.484 hours 1compartment NA NA Rat Human +DTXSID9040716 Css NA 0.05117 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040716 Css NA 0.2786 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040716 Css NA 0.03467 mg/L PBTK NA 50% Rat Human +DTXSID9040716 Css NA 0.1809 mg/L PBTK NA 95% Rat Human +DTXSID9040718 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040718 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040718 Vd NA 1.167 L/kg 1compartment NA NA Human Human +DTXSID9040718 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID9040718 TK.Half.Life NA 33.98 hours 1compartment NA NA Human Human +DTXSID9040718 Css NA 3.161 mg/L 3compartmentss NA 50% Human Human +DTXSID9040718 Css NA 11.63 mg/L 3compartmentss NA 95% Human Human +DTXSID9040718 Css NA 2.328 mg/L PBTK NA 50% Human Human +DTXSID9040718 Css NA 7.521 mg/L PBTK NA 95% Human Human +DTXSID9040718 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040718 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040718 Vd NA 0.9637 L/kg 1compartment NA NA Rat Human +DTXSID9040718 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9040718 TK.Half.Life NA 8.599 hours 1compartment NA NA Rat Human +DTXSID9040718 Css NA 0.2001 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040718 Css NA 0.6457 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040718 Css NA 0.1454 mg/L PBTK NA 50% Rat Human +DTXSID9040718 Css NA 0.3999 mg/L PBTK NA 95% Rat Human +DTXSID9040760 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040760 Fup 0.0259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040760 Vd NA 1.631 L/kg 1compartment NA NA Human Human +DTXSID9040760 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9040760 TK.Half.Life NA 12.33 hours 1compartment NA NA Human Human +DTXSID9040760 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human +DTXSID9040760 Css NA 9.402 mg/L 3compartmentss NA 95% Human Human +DTXSID9040760 Css NA 0.7176 mg/L PBTK NA 50% Human Human +DTXSID9040760 Css NA 5.943 mg/L PBTK NA 95% Human Human +DTXSID9040760 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040760 Fup 0.0259 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040760 Vd NA 1.247 L/kg 1compartment NA NA Rat Human +DTXSID9040760 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9040760 TK.Half.Life NA 4.885 hours 1compartment NA NA Rat Human +DTXSID9040760 Css NA 0.1366 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040760 Css NA 1.063 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040760 Css NA 0.09099 mg/L PBTK NA 50% Rat Human +DTXSID9040760 Css NA 0.6519 mg/L PBTK NA 95% Rat Human +DTXSID9040766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9040766 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9040766 Vd NA 1.127 L/kg 1compartment NA NA Human Human +DTXSID9040766 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9040766 TK.Half.Life NA 0.8117 hours 1compartment NA NA Human Human +DTXSID9040766 Css NA 0.02366 mg/L 3compartmentss NA 50% Human Human +DTXSID9040766 Css NA 0.2565 mg/L 3compartmentss NA 95% Human Human +DTXSID9040766 Css NA 0.02055 mg/L PBTK NA 50% Human Human +DTXSID9040766 Css NA 0.1882 mg/L PBTK NA 95% Human Human +DTXSID9040766 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9040766 Fup 0.87 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9040766 Vd NA 1.082 L/kg 1compartment NA NA Rat Human +DTXSID9040766 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9040766 TK.Half.Life NA 0.3747 hours 1compartment NA NA Rat Human +DTXSID9040766 Css NA 0.002741 mg/L 3compartmentss NA 50% Rat Human +DTXSID9040766 Css NA 0.02427 mg/L 3compartmentss NA 95% Rat Human +DTXSID9040766 Css NA 0.002479 mg/L PBTK NA 50% Rat Human +DTXSID9040766 Css NA 0.01783 mg/L PBTK NA 95% Rat Human DTXSID9041021 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9041021 Fup NA 0.9938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041021 Vd NA 0.6713 L/kg 1compartment NA NA Human Human +DTXSID9041021 Vd NA 0.6715 L/kg 1compartment NA NA Human Human DTXSID9041021 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9041021 TK.Half.Life NA 4.37 hours 1compartment NA NA Human Human -DTXSID9041021 Css NA 0.8915 mg/L 3compartmentss NA 50% Human Human -DTXSID9041021 Css NA 5.294 mg/L 3compartmentss NA 95% Human Human -DTXSID9041021 Css NA 0.7226 mg/L PBTK NA 50% Human Human -DTXSID9041021 Css NA 3.389 mg/L PBTK NA 95% Human Human +DTXSID9041021 Css NA 0.763 mg/L 3compartmentss NA 50% Human Human +DTXSID9041021 Css NA 4.345 mg/L 3compartmentss NA 95% Human Human +DTXSID9041021 Css NA 0.6182 mg/L PBTK NA 50% Human Human +DTXSID9041021 Css NA 2.82 mg/L PBTK NA 95% Human Human DTXSID9041021 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9041021 Fup NA 0.9938 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041021 Vd NA 0.7242 L/kg 1compartment NA NA Rat Human +DTXSID9041021 Vd NA 0.7244 L/kg 1compartment NA NA Rat Human DTXSID9041021 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9041021 TK.Half.Life NA 1.607 hours 1compartment NA NA Rat Human -DTXSID9041021 Css NA 0.2261 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041021 Css NA 1.215 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041021 Css NA 0.1787 mg/L PBTK NA 50% Rat Human -DTXSID9041021 Css NA 0.7302 mg/L PBTK NA 95% Rat Human -DTXSID9041023 Clint NA 48.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041023 Fup NA 0.0119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041023 Vd NA 3.718 L/kg 1compartment NA NA Human Human -DTXSID9041023 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9041023 TK.Half.Life NA 23.47 hours 1compartment NA NA Human Human -DTXSID9041023 Css NA 0.8159 mg/L 3compartmentss NA 50% Human Human -DTXSID9041023 Css NA 8.791 mg/L 3compartmentss NA 95% Human Human -DTXSID9041023 Css NA 0.6504 mg/L PBTK NA 50% Human Human -DTXSID9041023 Css NA 5.946 mg/L PBTK NA 95% Human Human -DTXSID9041023 Clint NA 48.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041023 Fup NA 0.0119 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041023 Vd NA 2.885 L/kg 1compartment NA NA Rat Human -DTXSID9041023 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9041023 TK.Half.Life NA 11.35 hours 1compartment NA NA Rat Human -DTXSID9041023 Css NA 0.463 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041023 Css NA 4.275 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041023 Css NA 0.3496 mg/L PBTK NA 50% Rat Human -DTXSID9041023 Css NA 2.658 mg/L PBTK NA 95% Rat Human -DTXSID9041104 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041104 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041104 Vd NA 0.6954 L/kg 1compartment NA NA Human Human +DTXSID9041021 Css NA 0.01426 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041021 Css NA 0.09695 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041021 Css NA 0.0112 mg/L PBTK NA 50% Rat Human +DTXSID9041021 Css NA 0.06327 mg/L PBTK NA 95% Rat Human +DTXSID9041023 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041023 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041023 Vd NA 4.14 L/kg 1compartment NA NA Human Human +DTXSID9041023 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID9041023 TK.Half.Life NA 46.9 hours 1compartment NA NA Human Human +DTXSID9041023 Css NA 1.405 mg/L 3compartmentss NA 50% Human Human +DTXSID9041023 Css NA 16.89 mg/L 3compartmentss NA 95% Human Human +DTXSID9041023 Css NA 1.162 mg/L PBTK NA 50% Human Human +DTXSID9041023 Css NA 11.37 mg/L PBTK NA 95% Human Human +DTXSID9041023 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041023 Fup 0.0142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041023 Vd NA 3.227 L/kg 1compartment NA NA Rat Human +DTXSID9041023 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID9041023 TK.Half.Life NA 22.58 hours 1compartment NA NA Rat Human +DTXSID9041023 Css NA 0.1822 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041023 Css NA 1.775 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041023 Css NA 0.1507 mg/L PBTK NA 50% Rat Human +DTXSID9041023 Css NA 1.159 mg/L PBTK NA 95% Rat Human +DTXSID9041104 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041104 Fup 0.744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041104 Vd NA 0.5848 L/kg 1compartment NA NA Human Human DTXSID9041104 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041104 TK.Half.Life NA 4.501 hours 1compartment NA NA Human Human -DTXSID9041104 Css NA 0.8479 mg/L 3compartmentss NA 50% Human Human -DTXSID9041104 Css NA 5.576 mg/L 3compartmentss NA 95% Human Human -DTXSID9041104 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID9041104 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID9041104 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041104 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041104 Vd NA 0.7461 L/kg 1compartment NA NA Rat Human +DTXSID9041104 TK.Half.Life NA 5.085 hours 1compartment NA NA Human Human +DTXSID9041104 Css NA 0.9193 mg/L 3compartmentss NA 50% Human Human +DTXSID9041104 Css NA 5.733 mg/L 3compartmentss NA 95% Human Human +DTXSID9041104 Css NA 0.7236 mg/L PBTK NA 50% Human Human +DTXSID9041104 Css NA 3.592 mg/L PBTK NA 95% Human Human +DTXSID9041104 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041104 Fup 0.744 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041104 Vd NA 0.6265 L/kg 1compartment NA NA Rat Human DTXSID9041104 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041104 TK.Half.Life NA 1.645 hours 1compartment NA NA Rat Human -DTXSID9041104 Css NA 0.213 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041104 Css NA 1.339 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041104 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID9041104 Css NA 0.8001 mg/L PBTK NA 95% Rat Human +DTXSID9041104 TK.Half.Life NA 1.857 hours 1compartment NA NA Rat Human +DTXSID9041104 Css NA 0.01746 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041104 Css NA 0.1372 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041104 Css NA 0.01306 mg/L PBTK NA 50% Rat Human +DTXSID9041104 Css NA 0.08637 mg/L PBTK NA 95% Rat Human DTXSID9041152 Clint 12.7 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9041152 Fup 0.1 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human DTXSID9041152 Vd NA 7.939 L/kg 1compartment NA NA Human Human DTXSID9041152 Days.Css NA 1 Days PBTK NA NA Human Human DTXSID9041152 TK.Half.Life NA 23.54 hours 1compartment NA NA Human Human -DTXSID9041152 Css NA 0.3367 mg/L 3compartmentss NA 50% Human Human -DTXSID9041152 Css NA 2.434 mg/L 3compartmentss NA 95% Human Human -DTXSID9041152 Css NA 0.2382 mg/L PBTK NA 50% Human Human -DTXSID9041152 Css NA 1.602 mg/L PBTK NA 95% Human Human +DTXSID9041152 Css NA 0.2942 mg/L 3compartmentss NA 50% Human Human +DTXSID9041152 Css NA 2.132 mg/L 3compartmentss NA 95% Human Human +DTXSID9041152 Css NA 0.2264 mg/L PBTK NA 50% Human Human +DTXSID9041152 Css NA 1.64 mg/L PBTK NA 95% Human Human DTXSID9041152 Clint 138.3 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID9041152 Fup 0.05 NA NA https://doi.org/10.18637%2Fjss.v079.i04 NA Rat Rat DTXSID9041152 Vd NA 5.347 L/kg 1compartment NA NA Rat Rat DTXSID9041152 Days.Css NA 0 Days PBTK NA NA Rat Rat DTXSID9041152 TK.Half.Life NA 2.726 hours 1compartment NA NA Rat Rat -DTXSID9041152 Css NA 0.03192 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9041152 Css NA 0.2525 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9041152 Css NA 0.02178 mg/L PBTK NA 50% Rat Rat -DTXSID9041152 Css NA 0.1563 mg/L PBTK NA 95% Rat Rat +DTXSID9041152 Css NA 0.006171 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9041152 Css NA 0.04489 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9041152 Css NA 0.004928 mg/L PBTK NA 50% Rat Rat +DTXSID9041152 Css NA 0.0358 mg/L PBTK NA 95% Rat Rat DTXSID9041233 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9041233 Fup NA 0.1108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041233 Vd NA 0.3138 L/kg 1compartment NA NA Human Human -DTXSID9041233 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9041233 TK.Half.Life NA 18.32 hours 1compartment NA NA Human Human -DTXSID9041233 Css NA 9.044 mg/L 3compartmentss NA 50% Human Human -DTXSID9041233 Css NA 41.26 mg/L 3compartmentss NA 95% Human Human -DTXSID9041233 Css NA 5.634 mg/L PBTK NA 50% Human Human -DTXSID9041233 Css NA 24.52 mg/L PBTK NA 95% Human Human +DTXSID9041233 Vd NA 0.2398 L/kg 1compartment NA NA Human Human +DTXSID9041233 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9041233 TK.Half.Life NA 14 hours 1compartment NA NA Human Human +DTXSID9041233 Css NA 7.82 mg/L 3compartmentss NA 50% Human Human +DTXSID9041233 Css NA 36.87 mg/L 3compartmentss NA 95% Human Human +DTXSID9041233 Css NA 4.74 mg/L PBTK NA 50% Human Human +DTXSID9041233 Css NA 21.46 mg/L PBTK NA 95% Human Human DTXSID9041233 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9041233 Fup NA 0.1108 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041233 Vd NA 0.3152 L/kg 1compartment NA NA Rat Human +DTXSID9041233 Vd NA 0.2505 L/kg 1compartment NA NA Rat Human DTXSID9041233 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041233 TK.Half.Life NA 6.273 hours 1compartment NA NA Rat Human -DTXSID9041233 Css NA 2.529 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041233 Css NA 9.613 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041233 Css NA 1.479 mg/L PBTK NA 50% Rat Human -DTXSID9041233 Css NA 5.31 mg/L PBTK NA 95% Rat Human -DTXSID9041362 Clint NA 5.011 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041362 Fup NA 0.1477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041362 Vd NA 1.414 L/kg 1compartment NA NA Human Human +DTXSID9041233 TK.Half.Life NA 4.987 hours 1compartment NA NA Rat Human +DTXSID9041233 Css NA 0.1452 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041233 Css NA 0.9414 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041233 Css NA 0.08388 mg/L PBTK NA 50% Rat Human +DTXSID9041233 Css NA 0.5343 mg/L PBTK NA 95% Rat Human +DTXSID9041362 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041362 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041362 Vd NA 1.59 L/kg 1compartment NA NA Human Human DTXSID9041362 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041362 TK.Half.Life NA 8.705 hours 1compartment NA NA Human Human -DTXSID9041362 Css NA 0.7839 mg/L 3compartmentss NA 50% Human Human -DTXSID9041362 Css NA 4.772 mg/L 3compartmentss NA 95% Human Human -DTXSID9041362 Css NA 0.537 mg/L PBTK NA 50% Human Human -DTXSID9041362 Css NA 2.976 mg/L PBTK NA 95% Human Human -DTXSID9041362 Clint NA 5.011 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041362 Fup NA 0.1477 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041362 Vd NA 1.103 L/kg 1compartment NA NA Rat Human +DTXSID9041362 TK.Half.Life NA 4.731 hours 1compartment NA NA Human Human +DTXSID9041362 Css NA 0.3276 mg/L 3compartmentss NA 50% Human Human +DTXSID9041362 Css NA 2.477 mg/L 3compartmentss NA 95% Human Human +DTXSID9041362 Css NA 0.2162 mg/L PBTK NA 50% Human Human +DTXSID9041362 Css NA 1.558 mg/L PBTK NA 95% Human Human +DTXSID9041362 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041362 Fup 0.0967 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041362 Vd NA 1.213 L/kg 1compartment NA NA Rat Human DTXSID9041362 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041362 TK.Half.Life NA 3.438 hours 1compartment NA NA Rat Human -DTXSID9041362 Css NA 0.4032 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041362 Css NA 1.847 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041362 Css NA 0.2612 mg/L PBTK NA 50% Rat Human -DTXSID9041362 Css NA 1.093 mg/L PBTK NA 95% Rat Human -DTXSID9041366 Clint NA 23.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041366 Fup NA 0.4599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041366 Vd NA 1.132 L/kg 1compartment NA NA Human Human +DTXSID9041362 TK.Half.Life NA 1.789 hours 1compartment NA NA Rat Human +DTXSID9041362 Css NA 0.04216 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041362 Css NA 0.2505 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041362 Css NA 0.02753 mg/L PBTK NA 50% Rat Human +DTXSID9041362 Css NA 0.1554 mg/L PBTK NA 95% Rat Human +DTXSID9041366 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041366 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041366 Vd NA 0.582 L/kg 1compartment NA NA Human Human DTXSID9041366 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041366 TK.Half.Life NA 1.165 hours 1compartment NA NA Human Human -DTXSID9041366 Css NA 0.0437 mg/L 3compartmentss NA 50% Human Human -DTXSID9041366 Css NA 0.3508 mg/L 3compartmentss NA 95% Human Human -DTXSID9041366 Css NA 0.03422 mg/L PBTK NA 50% Human Human -DTXSID9041366 Css NA 0.2451 mg/L PBTK NA 95% Human Human -DTXSID9041366 Clint NA 23.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041366 Fup NA 0.4599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041366 Vd NA 0.9642 L/kg 1compartment NA NA Rat Human +DTXSID9041366 TK.Half.Life NA 1.237 hours 1compartment NA NA Human Human +DTXSID9041366 Css NA 0.198 mg/L 3compartmentss NA 50% Human Human +DTXSID9041366 Css NA 1.675 mg/L 3compartmentss NA 95% Human Human +DTXSID9041366 Css NA 0.127 mg/L PBTK NA 50% Human Human +DTXSID9041366 Css NA 1.027 mg/L PBTK NA 95% Human Human +DTXSID9041366 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041366 Fup 0.134 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041366 Vd NA 0.4927 L/kg 1compartment NA NA Rat Human DTXSID9041366 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041366 TK.Half.Life NA 0.4871 hours 1compartment NA NA Rat Human -DTXSID9041366 Css NA 0.02312 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041366 Css NA 0.1489 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041366 Css NA 0.01746 mg/L PBTK NA 50% Rat Human -DTXSID9041366 Css NA 0.09845 mg/L PBTK NA 95% Rat Human -DTXSID9041368 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041368 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041368 Vd NA 0.9223 L/kg 1compartment NA NA Human Human +DTXSID9041366 TK.Half.Life NA 0.5945 hours 1compartment NA NA Rat Human +DTXSID9041366 Css NA 0.02608 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041366 Css NA 0.1598 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041366 Css NA 0.01625 mg/L PBTK NA 50% Rat Human +DTXSID9041366 Css NA 0.09477 mg/L PBTK NA 95% Rat Human +DTXSID9041368 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041368 Fup 0.839 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041368 Vd NA 0.8298 L/kg 1compartment NA NA Human Human DTXSID9041368 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041368 TK.Half.Life NA 6.001 hours 1compartment NA NA Human Human -DTXSID9041368 Css NA 0.7956 mg/L 3compartmentss NA 50% Human Human -DTXSID9041368 Css NA 5.481 mg/L 3compartmentss NA 95% Human Human -DTXSID9041368 Css NA 0.6974 mg/L PBTK NA 50% Human Human -DTXSID9041368 Css NA 3.638 mg/L PBTK NA 95% Human Human -DTXSID9041368 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041368 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041368 Vd NA 0.9362 L/kg 1compartment NA NA Rat Human +DTXSID9041368 TK.Half.Life NA 6.436 hours 1compartment NA NA Human Human +DTXSID9041368 Css NA 0.9244 mg/L 3compartmentss NA 50% Human Human +DTXSID9041368 Css NA 5.543 mg/L 3compartmentss NA 95% Human Human +DTXSID9041368 Css NA 0.7779 mg/L PBTK NA 50% Human Human +DTXSID9041368 Css NA 3.601 mg/L PBTK NA 95% Human Human +DTXSID9041368 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041368 Fup 0.839 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041368 Vd NA 0.8409 L/kg 1compartment NA NA Rat Human DTXSID9041368 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041368 TK.Half.Life NA 2.067 hours 1compartment NA NA Rat Human -DTXSID9041368 Css NA 0.2009 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041368 Css NA 1.303 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041368 Css NA 0.1725 mg/L PBTK NA 50% Rat Human -DTXSID9041368 Css NA 0.7936 mg/L PBTK NA 95% Rat Human -DTXSID9041441 Clint NA 1.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041441 Fup NA 0.1272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041441 Vd NA 0.3733 L/kg 1compartment NA NA Human Human +DTXSID9041368 TK.Half.Life NA 2.213 hours 1compartment NA NA Rat Human +DTXSID9041368 Css NA 0.05461 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041368 Css NA 0.3121 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041368 Css NA 0.04628 mg/L PBTK NA 50% Rat Human +DTXSID9041368 Css NA 0.1959 mg/L PBTK NA 95% Rat Human +DTXSID9041441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041441 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041441 Vd NA 0.4646 L/kg 1compartment NA NA Human Human DTXSID9041441 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041441 TK.Half.Life NA 6.964 hours 1compartment NA NA Human Human -DTXSID9041441 Css NA 2.753 mg/L 3compartmentss NA 50% Human Human -DTXSID9041441 Css NA 14.49 mg/L 3compartmentss NA 95% Human Human -DTXSID9041441 Css NA 1.772 mg/L PBTK NA 50% Human Human -DTXSID9041441 Css NA 8.717 mg/L PBTK NA 95% Human Human -DTXSID9041441 Clint NA 1.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041441 Fup NA 0.1272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041441 Vd NA 0.3694 L/kg 1compartment NA NA Rat Human +DTXSID9041441 TK.Half.Life NA 0.7628 hours 1compartment NA NA Human Human +DTXSID9041441 Css NA 0.106 mg/L 3compartmentss NA 50% Human Human +DTXSID9041441 Css NA 0.7757 mg/L 3compartmentss NA 95% Human Human +DTXSID9041441 Css NA 0.07309 mg/L PBTK NA 50% Human Human +DTXSID9041441 Css NA 0.4966 mg/L PBTK NA 95% Human Human +DTXSID9041441 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041441 Fup 0.198 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041441 Vd NA 0.4614 L/kg 1compartment NA NA Rat Human DTXSID9041441 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041441 TK.Half.Life NA 3.466 hours 1compartment NA NA Rat Human -DTXSID9041441 Css NA 1.149 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041441 Css NA 4.863 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041441 Css NA 0.6966 mg/L PBTK NA 50% Rat Human -DTXSID9041441 Css NA 2.715 mg/L PBTK NA 95% Rat Human -DTXSID9041491 Clint NA 7.468 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041491 Fup NA 0.3611 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041491 Vd NA 1.446 L/kg 1compartment NA NA Human Human +DTXSID9041441 TK.Half.Life NA 0.4227 hours 1compartment NA NA Rat Human +DTXSID9041441 Css NA 0.01362 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041441 Css NA 0.07058 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041441 Css NA 0.009343 mg/L PBTK NA 50% Rat Human +DTXSID9041441 Css NA 0.04575 mg/L PBTK NA 95% Rat Human +DTXSID9041491 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041491 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041491 Vd NA 1.214 L/kg 1compartment NA NA Human Human DTXSID9041491 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041491 TK.Half.Life NA 3.118 hours 1compartment NA NA Human Human -DTXSID9041491 Css NA 0.1765 mg/L 3compartmentss NA 50% Human Human -DTXSID9041491 Css NA 1.11 mg/L 3compartmentss NA 95% Human Human -DTXSID9041491 Css NA 0.138 mg/L PBTK NA 50% Human Human -DTXSID9041491 Css NA 0.7777 mg/L PBTK NA 95% Human Human -DTXSID9041491 Clint NA 7.468 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041491 Fup NA 0.3611 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041491 Vd NA 1.194 L/kg 1compartment NA NA Rat Human +DTXSID9041491 TK.Half.Life NA 1.766 hours 1compartment NA NA Human Human +DTXSID9041491 Css NA 0.0853 mg/L 3compartmentss NA 50% Human Human +DTXSID9041491 Css NA 0.6047 mg/L 3compartmentss NA 95% Human Human +DTXSID9041491 Css NA 0.06254 mg/L PBTK NA 50% Human Human +DTXSID9041491 Css NA 0.4091 mg/L PBTK NA 95% Human Human +DTXSID9041491 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041491 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041491 Vd NA 0.9986 L/kg 1compartment NA NA Rat Human DTXSID9041491 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041491 TK.Half.Life NA 1.307 hours 1compartment NA NA Rat Human -DTXSID9041491 Css NA 0.08958 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041491 Css NA 0.4299 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041491 Css NA 0.0678 mg/L PBTK NA 50% Rat Human -DTXSID9041491 Css NA 0.287 mg/L PBTK NA 95% Rat Human -DTXSID9041520 Clint NA 6.921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041520 Fup NA 0.5527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041520 Vd NA 1.696 L/kg 1compartment NA NA Human Human +DTXSID9041491 TK.Half.Life NA 0.7448 hours 1compartment NA NA Rat Human +DTXSID9041491 Css NA 0.01078 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041491 Css NA 0.05852 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041491 Css NA 0.007848 mg/L PBTK NA 50% Rat Human +DTXSID9041491 Css NA 0.03926 mg/L PBTK NA 95% Rat Human +DTXSID9041520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041520 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041520 Vd NA 1.189 L/kg 1compartment NA NA Human Human DTXSID9041520 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041520 TK.Half.Life NA 2.868 hours 1compartment NA NA Human Human -DTXSID9041520 Css NA 0.1276 mg/L 3compartmentss NA 50% Human Human -DTXSID9041520 Css NA 1.042 mg/L 3compartmentss NA 95% Human Human -DTXSID9041520 Css NA 0.1082 mg/L PBTK NA 50% Human Human -DTXSID9041520 Css NA 0.7249 mg/L PBTK NA 95% Human Human -DTXSID9041520 Clint NA 6.921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041520 Fup NA 0.5527 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041520 Vd NA 1.418 L/kg 1compartment NA NA Rat Human +DTXSID9041520 TK.Half.Life NA 1.637 hours 1compartment NA NA Human Human +DTXSID9041520 Css NA 0.07501 mg/L 3compartmentss NA 50% Human Human +DTXSID9041520 Css NA 0.5914 mg/L 3compartmentss NA 95% Human Human +DTXSID9041520 Css NA 0.05578 mg/L PBTK NA 50% Human Human +DTXSID9041520 Css NA 0.4072 mg/L PBTK NA 95% Human Human +DTXSID9041520 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041520 Fup 0.282 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041520 Vd NA 0.9875 L/kg 1compartment NA NA Rat Human DTXSID9041520 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041520 TK.Half.Life NA 1.156 hours 1compartment NA NA Rat Human -DTXSID9041520 Css NA 0.06249 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041520 Css NA 0.4293 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041520 Css NA 0.05202 mg/L PBTK NA 50% Rat Human -DTXSID9041520 Css NA 0.278 mg/L PBTK NA 95% Rat Human -DTXSID9041524 Clint NA 0.07143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041524 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041524 Vd NA 0.5176 L/kg 1compartment NA NA Human Human -DTXSID9041524 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041524 TK.Half.Life NA 2.988 hours 1compartment NA NA Human Human -DTXSID9041524 Css NA 0.8041 mg/L 3compartmentss NA 50% Human Human -DTXSID9041524 Css NA 4.937 mg/L 3compartmentss NA 95% Human Human -DTXSID9041524 Css NA 0.6103 mg/L PBTK NA 50% Human Human -DTXSID9041524 Css NA 3.18 mg/L PBTK NA 95% Human Human -DTXSID9041524 Clint NA 0.07143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041524 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041524 Vd NA 0.5404 L/kg 1compartment NA NA Rat Human -DTXSID9041524 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041524 TK.Half.Life NA 1.125 hours 1compartment NA NA Rat Human -DTXSID9041524 Css NA 0.2213 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041524 Css NA 1.285 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041524 Css NA 0.1627 mg/L PBTK NA 50% Rat Human -DTXSID9041524 Css NA 0.7488 mg/L PBTK NA 95% Rat Human -DTXSID9041528 Clint NA 2.689 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041528 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041528 Vd NA 1.088 L/kg 1compartment NA NA Human Human +DTXSID9041520 TK.Half.Life NA 0.6948 hours 1compartment NA NA Rat Human +DTXSID9041520 Css NA 0.009554 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041520 Css NA 0.05252 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041520 Css NA 0.007076 mg/L PBTK NA 50% Rat Human +DTXSID9041520 Css NA 0.03616 mg/L PBTK NA 95% Rat Human +DTXSID9041528 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041528 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041528 Vd NA 0.6697 L/kg 1compartment NA NA Human Human DTXSID9041528 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041528 TK.Half.Life NA 1.693 hours 1compartment NA NA Human Human -DTXSID9041528 Css NA 0.1464 mg/L 3compartmentss NA 50% Human Human -DTXSID9041528 Css NA 1.205 mg/L 3compartmentss NA 95% Human Human -DTXSID9041528 Css NA 0.1311 mg/L PBTK NA 50% Human Human -DTXSID9041528 Css NA 0.8451 mg/L PBTK NA 95% Human Human -DTXSID9041528 Clint NA 2.689 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041528 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041528 Vd NA 1.073 L/kg 1compartment NA NA Rat Human +DTXSID9041528 TK.Half.Life NA 0.7103 hours 1compartment NA NA Human Human +DTXSID9041528 Css NA 0.04295 mg/L 3compartmentss NA 50% Human Human +DTXSID9041528 Css NA 0.3654 mg/L 3compartmentss NA 95% Human Human +DTXSID9041528 Css NA 0.03232 mg/L PBTK NA 50% Human Human +DTXSID9041528 Css NA 0.2519 mg/L PBTK NA 95% Human Human +DTXSID9041528 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041528 Fup 0.446 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041528 Vd NA 0.6569 L/kg 1compartment NA NA Rat Human DTXSID9041528 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041528 TK.Half.Life NA 0.8644 hours 1compartment NA NA Rat Human -DTXSID9041528 Css NA 0.06332 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041528 Css NA 0.4574 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041528 Css NA 0.05667 mg/L PBTK NA 50% Rat Human -DTXSID9041528 Css NA 0.286 mg/L PBTK NA 95% Rat Human +DTXSID9041528 TK.Half.Life NA 0.3549 hours 1compartment NA NA Rat Human +DTXSID9041528 Css NA 0.005393 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041528 Css NA 0.03639 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041528 Css NA 0.004083 mg/L PBTK NA 50% Rat Human +DTXSID9041528 Css NA 0.02425 mg/L PBTK NA 95% Rat Human DTXSID9041570 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9041570 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9041570 Vd NA 0.8334 L/kg 1compartment NA NA Human Human DTXSID9041570 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9041570 TK.Half.Life NA 5.403 hours 1compartment NA NA Human Human -DTXSID9041570 Css NA 0.8144 mg/L 3compartmentss NA 50% Human Human -DTXSID9041570 Css NA 5.681 mg/L 3compartmentss NA 95% Human Human -DTXSID9041570 Css NA 0.6964 mg/L PBTK NA 50% Human Human -DTXSID9041570 Css NA 3.672 mg/L PBTK NA 95% Human Human +DTXSID9041570 Css NA 0.6901 mg/L 3compartmentss NA 50% Human Human +DTXSID9041570 Css NA 5.08 mg/L 3compartmentss NA 95% Human Human +DTXSID9041570 Css NA 0.5904 mg/L PBTK NA 50% Human Human +DTXSID9041570 Css NA 3.291 mg/L PBTK NA 95% Human Human DTXSID9041570 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9041570 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9041570 Vd NA 0.8616 L/kg 1compartment NA NA Rat Human DTXSID9041570 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9041570 TK.Half.Life NA 1.901 hours 1compartment NA NA Rat Human -DTXSID9041570 Css NA 0.205 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041570 Css NA 1.238 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041570 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID9041570 Css NA 0.7536 mg/L PBTK NA 95% Rat Human -DTXSID9041607 Clint NA 8.346 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041607 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041607 Vd NA 1.495 L/kg 1compartment NA NA Human Human +DTXSID9041570 Css NA 0.01252 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041570 Css NA 0.1004 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041570 Css NA 0.0104 mg/L PBTK NA 50% Rat Human +DTXSID9041570 Css NA 0.06659 mg/L PBTK NA 95% Rat Human +DTXSID9041607 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041607 Fup 0.612 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041607 Vd NA 1.107 L/kg 1compartment NA NA Human Human DTXSID9041607 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041607 TK.Half.Life NA 1.33 hours 1compartment NA NA Human Human -DTXSID9041607 Css NA 0.05258 mg/L 3compartmentss NA 50% Human Human -DTXSID9041607 Css NA 0.5851 mg/L 3compartmentss NA 95% Human Human -DTXSID9041607 Css NA 0.04957 mg/L PBTK NA 50% Human Human -DTXSID9041607 Css NA 0.4622 mg/L PBTK NA 95% Human Human -DTXSID9041607 Clint NA 8.346 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041607 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041607 Vd NA 1.424 L/kg 1compartment NA NA Rat Human +DTXSID9041607 TK.Half.Life NA 1.62 hours 1compartment NA NA Human Human +DTXSID9041607 Css NA 0.105 mg/L 3compartmentss NA 50% Human Human +DTXSID9041607 Css NA 0.9453 mg/L 3compartmentss NA 95% Human Human +DTXSID9041607 Css NA 0.0886 mg/L PBTK NA 50% Human Human +DTXSID9041607 Css NA 0.6481 mg/L PBTK NA 95% Human Human +DTXSID9041607 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041607 Fup 0.612 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041607 Vd NA 1.049 L/kg 1compartment NA NA Rat Human DTXSID9041607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041607 TK.Half.Life NA 0.6388 hours 1compartment NA NA Rat Human -DTXSID9041607 Css NA 0.02471 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041607 Css NA 0.2139 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041607 Css NA 0.02356 mg/L PBTK NA 50% Rat Human -DTXSID9041607 Css NA 0.1499 mg/L PBTK NA 95% Rat Human +DTXSID9041607 TK.Half.Life NA 0.8192 hours 1compartment NA NA Rat Human +DTXSID9041607 Css NA 0.01186 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041607 Css NA 0.09405 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041607 Css NA 0.01017 mg/L PBTK NA 50% Rat Human +DTXSID9041607 Css NA 0.06114 mg/L PBTK NA 95% Rat Human DTXSID9041653 Clint 268 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9041653 Fup 0.0335 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9041653 Vd NA 0.2304 L/kg 1compartment NA NA Human Human +DTXSID9041653 Vd NA 0.2899 L/kg 1compartment NA NA Human Human DTXSID9041653 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041653 TK.Half.Life NA 0.3202 hours 1compartment NA NA Human Human -DTXSID9041653 Css NA 0.0618 mg/L 3compartmentss NA 50% Human Human -DTXSID9041653 Css NA 0.5233 mg/L 3compartmentss NA 95% Human Human -DTXSID9041653 Css NA 0.03684 mg/L PBTK NA 50% Human Human -DTXSID9041653 Css NA 0.3031 mg/L PBTK NA 95% Human Human +DTXSID9041653 TK.Half.Life NA 0.399 hours 1compartment NA NA Human Human +DTXSID9041653 Css NA 0.05673 mg/L 3compartmentss NA 50% Human Human +DTXSID9041653 Css NA 0.5174 mg/L 3compartmentss NA 95% Human Human +DTXSID9041653 Css NA 0.03421 mg/L PBTK NA 50% Human Human +DTXSID9041653 Css NA 0.3026 mg/L PBTK NA 95% Human Human DTXSID9041653 Clint 268 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9041653 Fup 0.0335 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9041653 Vd NA 0.216 L/kg 1compartment NA NA Rat Human +DTXSID9041653 Vd NA 0.2556 L/kg 1compartment NA NA Rat Human DTXSID9041653 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041653 TK.Half.Life NA 0.1553 hours 1compartment NA NA Rat Human -DTXSID9041653 Css NA 0.03688 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041653 Css NA 0.2438 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041653 Css NA 0.02052 mg/L PBTK NA 50% Rat Human -DTXSID9041653 Css NA 0.1355 mg/L PBTK NA 95% Rat Human +DTXSID9041653 TK.Half.Life NA 0.1816 hours 1compartment NA NA Rat Human +DTXSID9041653 Css NA 0.007757 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041653 Css NA 0.05557 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041653 Css NA 0.004504 mg/L PBTK NA 50% Rat Human +DTXSID9041653 Css NA 0.03164 mg/L PBTK NA 95% Rat Human DTXSID9041659 Clint NA 0.002583 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9041659 Fup NA 0.1628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9041659 Vd NA 0.3971 L/kg 1compartment NA NA Human Human DTXSID9041659 Days.Css NA 2 Days PBTK NA NA Human Human DTXSID9041659 TK.Half.Life NA 15.71 hours 1compartment NA NA Human Human -DTXSID9041659 Css NA 5.118 mg/L 3compartmentss NA 50% Human Human -DTXSID9041659 Css NA 21.14 mg/L 3compartmentss NA 95% Human Human -DTXSID9041659 Css NA 3.387 mg/L PBTK NA 50% Human Human -DTXSID9041659 Css NA 12.68 mg/L PBTK NA 95% Human Human +DTXSID9041659 Css NA 5.028 mg/L 3compartmentss NA 50% Human Human +DTXSID9041659 Css NA 20.35 mg/L 3compartmentss NA 95% Human Human +DTXSID9041659 Css NA 3.319 mg/L PBTK NA 50% Human Human +DTXSID9041659 Css NA 12.35 mg/L PBTK NA 95% Human Human DTXSID9041659 Clint NA 0.002583 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9041659 Fup NA 0.1628 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9041659 Vd NA 0.396 L/kg 1compartment NA NA Rat Human DTXSID9041659 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9041659 TK.Half.Life NA 5.352 hours 1compartment NA NA Rat Human -DTXSID9041659 Css NA 1.439 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041659 Css NA 5.304 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041659 Css NA 0.8974 mg/L PBTK NA 50% Rat Human -DTXSID9041659 Css NA 2.997 mg/L PBTK NA 95% Rat Human -DTXSID9041813 Clint NA 2.996 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041813 Fup NA 0.4542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041813 Vd NA 2.124 L/kg 1compartment NA NA Human Human +DTXSID9041659 Css NA 0.323 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041659 Css NA 1.166 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041659 Css NA 0.2084 mg/L PBTK NA 50% Rat Human +DTXSID9041659 Css NA 0.6833 mg/L PBTK NA 95% Rat Human +DTXSID9041813 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041813 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041813 Vd NA 1.48 L/kg 1compartment NA NA Human Human DTXSID9041813 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041813 TK.Half.Life NA 9.082 hours 1compartment NA NA Human Human -DTXSID9041813 Css NA 0.4114 mg/L 3compartmentss NA 50% Human Human -DTXSID9041813 Css NA 2.133 mg/L 3compartmentss NA 95% Human Human -DTXSID9041813 Css NA 0.3375 mg/L PBTK NA 50% Human Human -DTXSID9041813 Css NA 1.497 mg/L PBTK NA 95% Human Human -DTXSID9041813 Clint NA 2.996 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041813 Fup NA 0.4542 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041813 Vd NA 1.692 L/kg 1compartment NA NA Rat Human +DTXSID9041813 TK.Half.Life NA 1.701 hours 1compartment NA NA Human Human +DTXSID9041813 Css NA 0.05312 mg/L 3compartmentss NA 50% Human Human +DTXSID9041813 Css NA 0.4089 mg/L 3compartmentss NA 95% Human Human +DTXSID9041813 Css NA 0.04234 mg/L PBTK NA 50% Human Human +DTXSID9041813 Css NA 0.2906 mg/L PBTK NA 95% Human Human +DTXSID9041813 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041813 Fup 0.403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041813 Vd NA 1.228 L/kg 1compartment NA NA Rat Human DTXSID9041813 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041813 TK.Half.Life NA 2.881 hours 1compartment NA NA Rat Human -DTXSID9041813 Css NA 0.1948 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041813 Css NA 0.7766 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041813 Css NA 0.1541 mg/L PBTK NA 50% Rat Human -DTXSID9041813 Css NA 0.5076 mg/L PBTK NA 95% Rat Human -DTXSID9041815 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041815 Fup NA 0.3178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041815 Vd NA 2.745 L/kg 1compartment NA NA Human Human +DTXSID9041813 TK.Half.Life NA 0.6856 hours 1compartment NA NA Rat Human +DTXSID9041813 Css NA 0.006533 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041813 Css NA 0.03898 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041813 Css NA 0.005274 mg/L PBTK NA 50% Rat Human +DTXSID9041813 Css NA 0.02738 mg/L PBTK NA 95% Rat Human +DTXSID9041815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041815 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041815 Vd NA 2.394 L/kg 1compartment NA NA Human Human DTXSID9041815 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041815 TK.Half.Life NA 11.36 hours 1compartment NA NA Human Human -DTXSID9041815 Css NA 0.4094 mg/L 3compartmentss NA 50% Human Human -DTXSID9041815 Css NA 2.311 mg/L 3compartmentss NA 95% Human Human -DTXSID9041815 Css NA 0.3036 mg/L PBTK NA 50% Human Human -DTXSID9041815 Css NA 1.634 mg/L PBTK NA 95% Human Human -DTXSID9041815 Clint NA 10.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041815 Fup NA 0.3178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041815 Vd NA 2.096 L/kg 1compartment NA NA Rat Human +DTXSID9041815 TK.Half.Life NA 4.78 hours 1compartment NA NA Human Human +DTXSID9041815 Css NA 0.1466 mg/L 3compartmentss NA 50% Human Human +DTXSID9041815 Css NA 0.9491 mg/L 3compartmentss NA 95% Human Human +DTXSID9041815 Css NA 0.1092 mg/L PBTK NA 50% Human Human +DTXSID9041815 Css NA 0.6657 mg/L PBTK NA 95% Human Human +DTXSID9041815 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041815 Fup 0.273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041815 Vd NA 1.842 L/kg 1compartment NA NA Rat Human DTXSID9041815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041815 TK.Half.Life NA 2.63 hours 1compartment NA NA Rat Human -DTXSID9041815 Css NA 0.2152 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041815 Css NA 0.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041815 Css NA 0.1545 mg/L PBTK NA 50% Rat Human -DTXSID9041815 Css NA 0.6301 mg/L PBTK NA 95% Rat Human -DTXSID9041861 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041861 Fup NA 0.8577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9041861 Vd NA 0.6589 L/kg 1compartment NA NA Human Human +DTXSID9041815 TK.Half.Life NA 1.433 hours 1compartment NA NA Rat Human +DTXSID9041815 Css NA 0.01854 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041815 Css NA 0.09175 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041815 Css NA 0.01384 mg/L PBTK NA 50% Rat Human +DTXSID9041815 Css NA 0.06526 mg/L PBTK NA 95% Rat Human +DTXSID9041861 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041861 Fup 0.714 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9041861 Vd NA 0.7462 L/kg 1compartment NA NA Human Human DTXSID9041861 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9041861 TK.Half.Life NA 4.987 hours 1compartment NA NA Human Human -DTXSID9041861 Css NA 0.9924 mg/L 3compartmentss NA 50% Human Human -DTXSID9041861 Css NA 5.986 mg/L 3compartmentss NA 95% Human Human -DTXSID9041861 Css NA 0.7864 mg/L PBTK NA 50% Human Human -DTXSID9041861 Css NA 3.812 mg/L PBTK NA 95% Human Human -DTXSID9041861 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041861 Fup NA 0.8577 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9041861 Vd NA 0.6695 L/kg 1compartment NA NA Rat Human +DTXSID9041861 TK.Half.Life NA 6.863 hours 1compartment NA NA Human Human +DTXSID9041861 Css NA 0.9316 mg/L 3compartmentss NA 50% Human Human +DTXSID9041861 Css NA 6.216 mg/L 3compartmentss NA 95% Human Human +DTXSID9041861 Css NA 0.7488 mg/L PBTK NA 50% Human Human +DTXSID9041861 Css NA 3.923 mg/L PBTK NA 95% Human Human +DTXSID9041861 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041861 Fup 0.714 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9041861 Vd NA 0.7241 L/kg 1compartment NA NA Rat Human DTXSID9041861 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9041861 TK.Half.Life NA 1.722 hours 1compartment NA NA Rat Human -DTXSID9041861 Css NA 0.255 mg/L 3compartmentss NA 50% Rat Human -DTXSID9041861 Css NA 1.457 mg/L 3compartmentss NA 95% Rat Human -DTXSID9041861 Css NA 0.1948 mg/L PBTK NA 50% Rat Human -DTXSID9041861 Css NA 0.8606 mg/L PBTK NA 95% Rat Human -DTXSID9042124 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042124 Fup NA 0.2346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042124 Vd NA 0.3099 L/kg 1compartment NA NA Human Human -DTXSID9042124 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042124 TK.Half.Life NA 8.548 hours 1compartment NA NA Human Human -DTXSID9042124 Css NA 3.481 mg/L 3compartmentss NA 50% Human Human -DTXSID9042124 Css NA 12.34 mg/L 3compartmentss NA 95% Human Human -DTXSID9042124 Css NA 2.272 mg/L PBTK NA 50% Human Human -DTXSID9042124 Css NA 7.52 mg/L PBTK NA 95% Human Human -DTXSID9042124 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042124 Fup NA 0.2346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042124 Vd NA 0.3311 L/kg 1compartment NA NA Rat Human -DTXSID9042124 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042124 TK.Half.Life NA 3.112 hours 1compartment NA NA Rat Human -DTXSID9042124 Css NA 0.9676 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042124 Css NA 2.962 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042124 Css NA 0.594 mg/L PBTK NA 50% Rat Human -DTXSID9042124 Css NA 1.677 mg/L PBTK NA 95% Rat Human +DTXSID9041861 TK.Half.Life NA 2.244 hours 1compartment NA NA Rat Human +DTXSID9041861 Css NA 0.01772 mg/L 3compartmentss NA 50% Rat Human +DTXSID9041861 Css NA 0.1469 mg/L 3compartmentss NA 95% Rat Human +DTXSID9041861 Css NA 0.01357 mg/L PBTK NA 50% Rat Human +DTXSID9041861 Css NA 0.09167 mg/L PBTK NA 95% Rat Human +DTXSID9042093 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042093 Fup 0.336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042093 Vd NA 1.652 L/kg 1compartment NA NA Human Human +DTXSID9042093 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID9042093 TK.Half.Life NA 43.35 hours 1compartment NA NA Human Human +DTXSID9042093 Css NA 2.7 mg/L 3compartmentss NA 50% Human Human +DTXSID9042093 Css NA 9.913 mg/L 3compartmentss NA 95% Human Human +DTXSID9042093 Css NA 2.112 mg/L PBTK NA 50% Human Human +DTXSID9042093 Css NA 6.587 mg/L PBTK NA 95% Human Human +DTXSID9042093 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042093 Fup 0.336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042093 Vd NA 1.331 L/kg 1compartment NA NA Rat Human +DTXSID9042093 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9042093 TK.Half.Life NA 9.487 hours 1compartment NA NA Rat Human +DTXSID9042093 Css NA 0.1714 mg/L 3compartmentss NA 50% Rat Human +DTXSID9042093 Css NA 0.5491 mg/L 3compartmentss NA 95% Rat Human +DTXSID9042093 Css NA 0.1328 mg/L PBTK NA 50% Rat Human +DTXSID9042093 Css NA 0.3517 mg/L PBTK NA 95% Rat Human +DTXSID9042097 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042097 Fup 0.358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042097 Vd NA 3.012 L/kg 1compartment NA NA Human Human +DTXSID9042097 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9042097 TK.Half.Life NA 12.23 hours 1compartment NA NA Human Human +DTXSID9042097 Css NA 0.3854 mg/L 3compartmentss NA 50% Human Human +DTXSID9042097 Css NA 2.429 mg/L 3compartmentss NA 95% Human Human +DTXSID9042097 Css NA 0.279 mg/L PBTK NA 50% Human Human +DTXSID9042097 Css NA 1.704 mg/L PBTK NA 95% Human Human +DTXSID9042097 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042097 Fup 0.358 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042097 Vd NA 2.28 L/kg 1compartment NA NA Rat Human +DTXSID9042097 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9042097 TK.Half.Life NA 2.327 hours 1compartment NA NA Rat Human +DTXSID9042097 Css NA 0.04828 mg/L 3compartmentss NA 50% Rat Human +DTXSID9042097 Css NA 0.2373 mg/L 3compartmentss NA 95% Rat Human +DTXSID9042097 Css NA 0.03498 mg/L PBTK NA 50% Rat Human +DTXSID9042097 Css NA 0.169 mg/L PBTK NA 95% Rat Human DTXSID9042170 Clint 2.573 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID9042170 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID9042170 Vd NA 1.642 L/kg 1compartment NA NA Human Human +DTXSID9042170 Vd NA 1.928 L/kg 1compartment NA NA Human Human DTXSID9042170 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042170 TK.Half.Life NA 2.551 hours 1compartment NA NA Human Human -DTXSID9042170 Css NA 0.1333 mg/L 3compartmentss NA 50% Human Human -DTXSID9042170 Css NA 0.5492 mg/L 3compartmentss NA 95% Human Human -DTXSID9042170 Css NA 0.1276 mg/L PBTK NA 50% Human Human -DTXSID9042170 Css NA 0.4744 mg/L PBTK NA 95% Human Human +DTXSID9042170 TK.Half.Life NA 2.986 hours 1compartment NA NA Human Human +DTXSID9042170 Css NA 0.1218 mg/L 3compartmentss NA 50% Human Human +DTXSID9042170 Css NA 0.5081 mg/L 3compartmentss NA 95% Human Human +DTXSID9042170 Css NA 0.122 mg/L PBTK NA 50% Human Human +DTXSID9042170 Css NA 0.4639 mg/L PBTK NA 95% Human Human DTXSID9042170 Clint 2.573 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID9042170 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID9042170 Vd NA 1.663 L/kg 1compartment NA NA Rat Human +DTXSID9042170 Vd NA 1.941 L/kg 1compartment NA NA Rat Human DTXSID9042170 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042170 TK.Half.Life NA 1.356 hours 1compartment NA NA Rat Human -DTXSID9042170 Css NA 0.05754 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042170 Css NA 0.1776 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042170 Css NA 0.05574 mg/L PBTK NA 50% Rat Human -DTXSID9042170 Css NA 0.1447 mg/L PBTK NA 95% Rat Human -DTXSID9042203 Clint NA 12.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042203 Fup NA 0.0968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042203 Vd NA 2.546 L/kg 1compartment NA NA Human Human -DTXSID9042203 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9042203 TK.Half.Life NA 19.29 hours 1compartment NA NA Human Human -DTXSID9042203 Css NA 0.9516 mg/L 3compartmentss NA 50% Human Human -DTXSID9042203 Css NA 5.834 mg/L 3compartmentss NA 95% Human Human -DTXSID9042203 Css NA 0.6557 mg/L PBTK NA 50% Human Human -DTXSID9042203 Css NA 3.892 mg/L PBTK NA 95% Human Human -DTXSID9042203 Clint NA 12.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042203 Fup NA 0.0968 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042203 Vd NA 1.917 L/kg 1compartment NA NA Rat Human -DTXSID9042203 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042203 TK.Half.Life NA 4.741 hours 1compartment NA NA Rat Human -DTXSID9042203 Css NA 0.5164 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042203 Css NA 2.402 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042203 Css NA 0.3384 mg/L PBTK NA 50% Rat Human -DTXSID9042203 Css NA 1.517 mg/L PBTK NA 95% Rat Human -DTXSID9042209 Clint NA 79.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042209 Fup NA 0.0387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042209 Vd NA 3.118 L/kg 1compartment NA NA Human Human -DTXSID9042209 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042209 TK.Half.Life NA 2.045 hours 1compartment NA NA Human Human -DTXSID9042209 Css NA 0.008215 mg/L 3compartmentss NA 50% Human Human -DTXSID9042209 Css NA 0.08399 mg/L 3compartmentss NA 95% Human Human -DTXSID9042209 Css NA 0.007239 mg/L PBTK NA 50% Human Human -DTXSID9042209 Css NA 0.06181 mg/L PBTK NA 95% Human Human -DTXSID9042209 Clint NA 79.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042209 Fup NA 0.0387 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042209 Vd NA 2.805 L/kg 1compartment NA NA Rat Human -DTXSID9042209 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042209 TK.Half.Life NA 0.818 hours 1compartment NA NA Rat Human -DTXSID9042209 Css NA 0.004526 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042209 Css NA 0.03828 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042209 Css NA 0.003899 mg/L PBTK NA 50% Rat Human -DTXSID9042209 Css NA 0.02743 mg/L PBTK NA 95% Rat Human -DTXSID9042259 Clint NA 4.569 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042259 Fup NA 0.0684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042259 Vd NA 0.7469 L/kg 1compartment NA NA Human Human +DTXSID9042170 TK.Half.Life NA 1.575 hours 1compartment NA NA Rat Human +DTXSID9042170 Css NA 0.01222 mg/L 3compartmentss NA 50% Rat Human +DTXSID9042170 Css NA 0.03731 mg/L 3compartmentss NA 95% Rat Human +DTXSID9042170 Css NA 0.01293 mg/L PBTK NA 50% Rat Human +DTXSID9042170 Css NA 0.03307 mg/L PBTK NA 95% Rat Human +DTXSID9042259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042259 Fup 0.0342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042259 Vd NA 0.828 L/kg 1compartment NA NA Human Human DTXSID9042259 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042259 TK.Half.Life NA 8.733 hours 1compartment NA NA Human Human -DTXSID9042259 Css NA 1.919 mg/L 3compartmentss NA 50% Human Human -DTXSID9042259 Css NA 11.74 mg/L 3compartmentss NA 95% Human Human -DTXSID9042259 Css NA 1.2 mg/L PBTK NA 50% Human Human -DTXSID9042259 Css NA 7.09 mg/L PBTK NA 95% Human Human -DTXSID9042259 Clint NA 4.569 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042259 Fup NA 0.0684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042259 Vd NA 0.5927 L/kg 1compartment NA NA Rat Human +DTXSID9042259 TK.Half.Life NA 4.77 hours 1compartment NA NA Human Human +DTXSID9042259 Css NA 0.8893 mg/L 3compartmentss NA 50% Human Human +DTXSID9042259 Css NA 6.595 mg/L 3compartmentss NA 95% Human Human +DTXSID9042259 Css NA 0.5486 mg/L PBTK NA 50% Human Human +DTXSID9042259 Css NA 3.909 mg/L PBTK NA 95% Human Human +DTXSID9042259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042259 Fup 0.0342 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042259 Vd NA 0.6311 L/kg 1compartment NA NA Rat Human DTXSID9042259 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042259 TK.Half.Life NA 4.023 hours 1compartment NA NA Rat Human -DTXSID9042259 Css NA 0.9904 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042259 Css NA 4.654 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042259 Css NA 0.5794 mg/L PBTK NA 50% Rat Human -DTXSID9042259 Css NA 2.593 mg/L PBTK NA 95% Rat Human -DTXSID9042336 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042336 Fup NA 0.9168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042336 Vd NA 0.6184 L/kg 1compartment NA NA Human Human +DTXSID9042259 TK.Half.Life NA 2.182 hours 1compartment NA NA Rat Human +DTXSID9042259 Css NA 0.1184 mg/L 3compartmentss NA 50% Rat Human +DTXSID9042259 Css NA 0.6874 mg/L 3compartmentss NA 95% Rat Human +DTXSID9042259 Css NA 0.06992 mg/L PBTK NA 50% Rat Human +DTXSID9042259 Css NA 0.3973 mg/L PBTK NA 95% Rat Human +DTXSID9042336 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042336 Fup 0.848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042336 Vd NA 0.6963 L/kg 1compartment NA NA Human Human DTXSID9042336 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042336 TK.Half.Life NA 4.37 hours 1compartment NA NA Human Human -DTXSID9042336 Css NA 0.9377 mg/L 3compartmentss NA 50% Human Human -DTXSID9042336 Css NA 3.361 mg/L 3compartmentss NA 95% Human Human -DTXSID9042336 Css NA 0.737 mg/L PBTK NA 50% Human Human -DTXSID9042336 Css NA 2.257 mg/L PBTK NA 95% Human Human -DTXSID9042336 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042336 Fup NA 0.9168 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042336 Vd NA 0.6333 L/kg 1compartment NA NA Rat Human +DTXSID9042336 TK.Half.Life NA 0.5497 hours 1compartment NA NA Human Human +DTXSID9042336 Css NA 0.02112 mg/L 3compartmentss NA 50% Human Human +DTXSID9042336 Css NA 0.2318 mg/L 3compartmentss NA 95% Human Human +DTXSID9042336 Css NA 0.01653 mg/L PBTK NA 50% Human Human +DTXSID9042336 Css NA 0.158 mg/L PBTK NA 95% Human Human +DTXSID9042336 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042336 Fup 0.848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042336 Vd NA 0.6931 L/kg 1compartment NA NA Rat Human DTXSID9042336 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042336 TK.Half.Life NA 1.524 hours 1compartment NA NA Rat Human -DTXSID9042336 Css NA 0.2415 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042336 Css NA 0.8172 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042336 Css NA 0.1835 mg/L PBTK NA 50% Rat Human -DTXSID9042336 Css NA 0.5063 mg/L PBTK NA 95% Rat Human -DTXSID9042338 Clint NA 28.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042338 Fup NA 0.3734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042338 Vd NA 1.15 L/kg 1compartment NA NA Human Human -DTXSID9042338 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042338 TK.Half.Life NA 1.219 hours 1compartment NA NA Human Human -DTXSID9042338 Css NA 0.04458 mg/L 3compartmentss NA 50% Human Human -DTXSID9042338 Css NA 0.3374 mg/L 3compartmentss NA 95% Human Human -DTXSID9042338 Css NA 0.03448 mg/L PBTK NA 50% Human Human -DTXSID9042338 Css NA 0.2354 mg/L PBTK NA 95% Human Human -DTXSID9042338 Clint NA 28.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042338 Fup NA 0.3734 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042338 Vd NA 0.9862 L/kg 1compartment NA NA Rat Human -DTXSID9042338 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042338 TK.Half.Life NA 0.518 hours 1compartment NA NA Rat Human -DTXSID9042338 Css NA 0.024 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042338 Css NA 0.1445 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042338 Css NA 0.01801 mg/L PBTK NA 50% Rat Human -DTXSID9042338 Css NA 0.09889 mg/L PBTK NA 95% Rat Human -DTXSID9042382 Clint NA 153.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042382 Fup NA 0.0253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042382 Vd NA 2.096 L/kg 1compartment NA NA Human Human -DTXSID9042382 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042382 TK.Half.Life NA 4.266 hours 1compartment NA NA Human Human -DTXSID9042382 Css NA 0.1918 mg/L 3compartmentss NA 50% Human Human -DTXSID9042382 Css NA 1.572 mg/L 3compartmentss NA 95% Human Human -DTXSID9042382 Css NA 0.1248 mg/L PBTK NA 50% Human Human -DTXSID9042382 Css NA 0.9742 mg/L PBTK NA 95% Human Human -DTXSID9042382 Clint NA 153.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042382 Fup NA 0.0253 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042382 Vd NA 1.562 L/kg 1compartment NA NA Rat Human +DTXSID9042336 TK.Half.Life NA 0.2617 hours 1compartment NA NA Rat Human +DTXSID9042336 Css NA 0.0007355 mg/L 3compartmentss NA 50% Rat Human +DTXSID9042336 Css NA 0.009057 mg/L 3compartmentss NA 95% Rat Human +DTXSID9042336 Css NA 0.0005639 mg/L PBTK NA 50% Rat Human +DTXSID9042336 Css NA 0.005996 mg/L PBTK NA 95% Rat Human +DTXSID9042382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042382 Fup 0.0796 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042382 Vd NA 2.622 L/kg 1compartment NA NA Human Human +DTXSID9042382 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9042382 TK.Half.Life NA 15.18 hours 1compartment NA NA Human Human +DTXSID9042382 Css NA 0.667 mg/L 3compartmentss NA 50% Human Human +DTXSID9042382 Css NA 4.475 mg/L 3compartmentss NA 95% Human Human +DTXSID9042382 Css NA 0.4569 mg/L PBTK NA 50% Human Human +DTXSID9042382 Css NA 2.948 mg/L PBTK NA 95% Human Human +DTXSID9042382 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042382 Fup 0.0796 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042382 Vd NA 1.971 L/kg 1compartment NA NA Rat Human DTXSID9042382 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042382 TK.Half.Life NA 1.356 hours 1compartment NA NA Rat Human -DTXSID9042382 Css NA 0.108 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042382 Css NA 0.7312 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042382 Css NA 0.06616 mg/L PBTK NA 50% Rat Human -DTXSID9042382 Css NA 0.4315 mg/L PBTK NA 95% Rat Human -DTXSID9042415 Clint NA 0.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042415 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042415 Vd NA 0.4776 L/kg 1compartment NA NA Human Human +DTXSID9042382 TK.Half.Life NA 3.629 hours 1compartment NA NA Rat Human +DTXSID9042382 Css NA 0.08726 mg/L 3compartmentss NA 50% Rat Human +DTXSID9042382 Css NA 0.4518 mg/L 3compartmentss NA 95% Rat Human +DTXSID9042382 Css NA 0.059 mg/L PBTK NA 50% Rat Human +DTXSID9042382 Css NA 0.2948 mg/L PBTK NA 95% Rat Human +DTXSID9042415 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042415 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042415 Vd NA 0.3951 L/kg 1compartment NA NA Human Human DTXSID9042415 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042415 TK.Half.Life NA 7.834 hours 1compartment NA NA Human Human -DTXSID9042415 Css NA 1.861 mg/L 3compartmentss NA 50% Human Human -DTXSID9042415 Css NA 7.666 mg/L 3compartmentss NA 95% Human Human -DTXSID9042415 Css NA 1.302 mg/L PBTK NA 50% Human Human -DTXSID9042415 Css NA 4.768 mg/L PBTK NA 95% Human Human -DTXSID9042415 Clint NA 0.399 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042415 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042415 Vd NA 0.4809 L/kg 1compartment NA NA Rat Human +DTXSID9042415 TK.Half.Life NA 0.365 hours 1compartment NA NA Human Human +DTXSID9042415 Css NA 0.01288 mg/L 3compartmentss NA 50% Human Human +DTXSID9042415 Css NA 0.1308 mg/L 3compartmentss NA 95% Human Human +DTXSID9042415 Css NA 0.008958 mg/L PBTK NA 50% Human Human +DTXSID9042415 Css NA 0.08536 mg/L PBTK NA 95% Human Human +DTXSID9042415 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042415 Fup 0.376 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042415 Vd NA 0.423 L/kg 1compartment NA NA Rat Human DTXSID9042415 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042415 TK.Half.Life NA 3.371 hours 1compartment NA NA Rat Human -DTXSID9042415 Css NA 0.6588 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042415 Css NA 2.201 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042415 Css NA 0.4376 mg/L PBTK NA 50% Rat Human -DTXSID9042415 Css NA 1.283 mg/L PBTK NA 95% Rat Human -DTXSID9042465 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042465 Fup NA 0.7127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042465 Vd NA 0.5593 L/kg 1compartment NA NA Human Human -DTXSID9042465 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042465 TK.Half.Life NA 5.078 hours 1compartment NA NA Human Human -DTXSID9042465 Css NA 1.123 mg/L 3compartmentss NA 50% Human Human -DTXSID9042465 Css NA 6.899 mg/L 3compartmentss NA 95% Human Human -DTXSID9042465 Css NA 0.8717 mg/L PBTK NA 50% Human Human -DTXSID9042465 Css NA 4.328 mg/L PBTK NA 95% Human Human -DTXSID9042465 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042465 Fup NA 0.7127 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042465 Vd NA 0.6024 L/kg 1compartment NA NA Rat Human -DTXSID9042465 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042465 TK.Half.Life NA 1.863 hours 1compartment NA NA Rat Human -DTXSID9042465 Css NA 0.292 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042465 Css NA 1.84 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042465 Css NA 0.2184 mg/L PBTK NA 50% Rat Human -DTXSID9042465 Css NA 1.071 mg/L PBTK NA 95% Rat Human -DTXSID9042592 Clint NA 40.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042592 Fup NA 0.0532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9042592 Vd NA 0.9321 L/kg 1compartment NA NA Human Human +DTXSID9042415 TK.Half.Life NA 0.1842 hours 1compartment NA NA Rat Human +DTXSID9042415 Css NA 0.0004433 mg/L 3compartmentss NA 50% Rat Human +DTXSID9042415 Css NA 0.005522 mg/L 3compartmentss NA 95% Rat Human +DTXSID9042415 Css NA 0.000301 mg/L PBTK NA 50% Rat Human +DTXSID9042415 Css NA 0.003435 mg/L PBTK NA 95% Rat Human +DTXSID90424897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90424897 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90424897 Vd NA 2.317 L/kg 1compartment NA NA Human Human +DTXSID90424897 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90424897 TK.Half.Life NA 7.554 hours 1compartment NA NA Human Human +DTXSID90424897 Css NA 0.313 mg/L 3compartmentss NA 50% Human Human +DTXSID90424897 Css NA 2.179 mg/L 3compartmentss NA 95% Human Human +DTXSID90424897 Css NA 0.2184 mg/L PBTK NA 50% Human Human +DTXSID90424897 Css NA 1.436 mg/L PBTK NA 95% Human Human +DTXSID90424897 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90424897 Fup 0.126 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90424897 Vd NA 1.761 L/kg 1compartment NA NA Rat Human +DTXSID90424897 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90424897 TK.Half.Life NA 2.241 hours 1compartment NA NA Rat Human +DTXSID90424897 Css NA 0.02481 mg/L 3compartmentss NA 50% Rat Human +DTXSID90424897 Css NA 0.1559 mg/L 3compartmentss NA 95% Rat Human +DTXSID90424897 Css NA 0.01722 mg/L PBTK NA 50% Rat Human +DTXSID90424897 Css NA 0.09933 mg/L PBTK NA 95% Rat Human +DTXSID9042592 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042592 Fup 0.0635 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9042592 Vd NA 1.988 L/kg 1compartment NA NA Human Human DTXSID9042592 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9042592 TK.Half.Life NA 2.429 hours 1compartment NA NA Human Human -DTXSID9042592 Css NA 0.3059 mg/L 3compartmentss NA 50% Human Human -DTXSID9042592 Css NA 2.509 mg/L 3compartmentss NA 95% Human Human -DTXSID9042592 Css NA 0.194 mg/L PBTK NA 50% Human Human -DTXSID9042592 Css NA 1.54 mg/L PBTK NA 95% Human Human -DTXSID9042592 Clint NA 40.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042592 Fup NA 0.0532 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9042592 Vd NA 0.815 L/kg 1compartment NA NA Rat Human +DTXSID9042592 TK.Half.Life NA 9.107 hours 1compartment NA NA Human Human +DTXSID9042592 Css NA 0.5668 mg/L 3compartmentss NA 50% Human Human +DTXSID9042592 Css NA 3.923 mg/L 3compartmentss NA 95% Human Human +DTXSID9042592 Css NA 0.375 mg/L PBTK NA 50% Human Human +DTXSID9042592 Css NA 2.484 mg/L PBTK NA 95% Human Human +DTXSID9042592 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042592 Fup 0.0635 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9042592 Vd NA 1.49 L/kg 1compartment NA NA Rat Human DTXSID9042592 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9042592 TK.Half.Life NA 1.242 hours 1compartment NA NA Rat Human -DTXSID9042592 Css NA 0.1714 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042592 Css NA 1.171 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042592 Css NA 0.1026 mg/L PBTK NA 50% Rat Human -DTXSID9042592 Css NA 0.6693 mg/L PBTK NA 95% Rat Human -DTXSID9042594 Clint NA 78.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9042592 TK.Half.Life NA 2.977 hours 1compartment NA NA Rat Human +DTXSID9042592 Css NA 0.07344 mg/L 3compartmentss NA 50% Rat Human +DTXSID9042592 Css NA 0.4136 mg/L 3compartmentss NA 95% Rat Human +DTXSID9042592 Css NA 0.04733 mg/L PBTK NA 50% Rat Human +DTXSID9042592 Css NA 0.2571 mg/L PBTK NA 95% Rat Human +DTXSID9042594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9042594 Fup 0.008 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9042594 Vd NA 2.936 L/kg 1compartment NA NA Human Human -DTXSID9042594 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9042594 TK.Half.Life NA 21.67 hours 1compartment NA NA Human Human -DTXSID9042594 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human -DTXSID9042594 Css NA 6.545 mg/L 3compartmentss NA 95% Human Human -DTXSID9042594 Css NA 0.6028 mg/L PBTK NA 50% Human Human -DTXSID9042594 Css NA 3.872 mg/L PBTK NA 95% Human Human -DTXSID9042594 Clint NA 78.39 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9042594 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID9042594 TK.Half.Life NA 71.58 hours 1compartment NA NA Human Human +DTXSID9042594 Css NA 2.884 mg/L 3compartmentss NA 50% Human Human +DTXSID9042594 Css NA 19.2 mg/L 3compartmentss NA 95% Human Human +DTXSID9042594 Css NA 1.874 mg/L PBTK NA 50% Human Human +DTXSID9042594 Css NA 12.48 mg/L PBTK NA 95% Human Human +DTXSID9042594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9042594 Fup 0.008 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9042594 Vd NA 2.289 L/kg 1compartment NA NA Rat Human -DTXSID9042594 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9042594 TK.Half.Life NA 3.418 hours 1compartment NA NA Rat Human -DTXSID9042594 Css NA 0.5412 mg/L 3compartmentss NA 50% Rat Human -DTXSID9042594 Css NA 2.816 mg/L 3compartmentss NA 95% Rat Human -DTXSID9042594 Css NA 0.2944 mg/L PBTK NA 50% Rat Human -DTXSID9042594 Css NA 1.528 mg/L PBTK NA 95% Rat Human +DTXSID9042594 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID9042594 TK.Half.Life NA 10.32 hours 1compartment NA NA Rat Human +DTXSID9042594 Css NA 0.1274 mg/L 3compartmentss NA 50% Rat Human +DTXSID9042594 Css NA 0.8362 mg/L 3compartmentss NA 95% Rat Human +DTXSID9042594 Css NA 0.08399 mg/L PBTK NA 50% Rat Human +DTXSID9042594 Css NA 0.561 mg/L PBTK NA 95% Rat Human +DTXSID90430791 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90430791 Fup 0.528 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90430791 Vd NA 1.657 L/kg 1compartment NA NA Human Human +DTXSID90430791 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90430791 TK.Half.Life NA 3.062 hours 1compartment NA NA Human Human +DTXSID90430791 Css NA 0.137 mg/L 3compartmentss NA 50% Human Human +DTXSID90430791 Css NA 1.028 mg/L 3compartmentss NA 95% Human Human +DTXSID90430791 Css NA 0.1149 mg/L PBTK NA 50% Human Human +DTXSID90430791 Css NA 0.7235 mg/L PBTK NA 95% Human Human +DTXSID90430791 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90430791 Fup 0.528 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90430791 Vd NA 1.384 L/kg 1compartment NA NA Rat Human +DTXSID90430791 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90430791 TK.Half.Life NA 1.242 hours 1compartment NA NA Rat Human +DTXSID90430791 Css NA 0.01591 mg/L 3compartmentss NA 50% Rat Human +DTXSID90430791 Css NA 0.09715 mg/L 3compartmentss NA 95% Rat Human +DTXSID90430791 Css NA 0.01358 mg/L PBTK NA 50% Rat Human +DTXSID90430791 Css NA 0.06495 mg/L PBTK NA 95% Rat Human +DTXSID90432396 Clint 9.087 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90432396 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90432396 Vd NA 1.958 L/kg 1compartment NA NA Human Human +DTXSID90432396 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90432396 TK.Half.Life NA 6.802 hours 1compartment NA NA Human Human +DTXSID90432396 Css NA 0.3273 mg/L 3compartmentss NA 50% Human Human +DTXSID90432396 Css NA 1.895 mg/L 3compartmentss NA 95% Human Human +DTXSID90432396 Css NA 0.2387 mg/L PBTK NA 50% Human Human +DTXSID90432396 Css NA 1.292 mg/L PBTK NA 95% Human Human +DTXSID90432396 Clint 9.087 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90432396 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90432396 Vd NA 1.516 L/kg 1compartment NA NA Rat Human +DTXSID90432396 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90432396 TK.Half.Life NA 2.328 hours 1compartment NA NA Rat Human +DTXSID90432396 Css NA 0.03955 mg/L 3compartmentss NA 50% Rat Human +DTXSID90432396 Css NA 0.1717 mg/L 3compartmentss NA 95% Rat Human +DTXSID90432396 Css NA 0.02875 mg/L PBTK NA 50% Rat Human +DTXSID90432396 Css NA 0.116 mg/L PBTK NA 95% Rat Human +DTXSID90433025 Clint 16.22 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90433025 Fup 0.0678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90433025 Vd NA 2.328 L/kg 1compartment NA NA Human Human +DTXSID90433025 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID90433025 TK.Half.Life NA 15.28 hours 1compartment NA NA Human Human +DTXSID90433025 Css NA 0.8352 mg/L 3compartmentss NA 50% Human Human +DTXSID90433025 Css NA 5.745 mg/L 3compartmentss NA 95% Human Human +DTXSID90433025 Css NA 0.5604 mg/L PBTK NA 50% Human Human +DTXSID90433025 Css NA 3.7 mg/L PBTK NA 95% Human Human +DTXSID90433025 Clint 16.22 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90433025 Fup 0.0678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90433025 Vd NA 1.749 L/kg 1compartment NA NA Rat Human +DTXSID90433025 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90433025 TK.Half.Life NA 4.279 hours 1compartment NA NA Rat Human +DTXSID90433025 Css NA 0.1065 mg/L 3compartmentss NA 50% Rat Human +DTXSID90433025 Css NA 0.5567 mg/L 3compartmentss NA 95% Rat Human +DTXSID90433025 Css NA 0.07035 mg/L PBTK NA 50% Rat Human +DTXSID90433025 Css NA 0.3552 mg/L PBTK NA 95% Rat Human +DTXSID9043774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9043774 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9043774 Vd NA 1.049 L/kg 1compartment NA NA Human Human +DTXSID9043774 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9043774 TK.Half.Life NA 9.294 hours 1compartment NA NA Human Human +DTXSID9043774 Css NA 1.26 mg/L 3compartmentss NA 50% Human Human +DTXSID9043774 Css NA 11.84 mg/L 3compartmentss NA 95% Human Human +DTXSID9043774 Css NA 0.7698 mg/L PBTK NA 50% Human Human +DTXSID9043774 Css NA 7.004 mg/L PBTK NA 95% Human Human +DTXSID9043774 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9043774 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9043774 Vd NA 0.7817 L/kg 1compartment NA NA Rat Human +DTXSID9043774 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9043774 TK.Half.Life NA 4.042 hours 1compartment NA NA Rat Human +DTXSID9043774 Css NA 0.06268 mg/L 3compartmentss NA 50% Rat Human +DTXSID9043774 Css NA 0.6535 mg/L 3compartmentss NA 95% Rat Human +DTXSID9043774 Css NA 0.0368 mg/L PBTK NA 50% Rat Human +DTXSID9043774 Css NA 0.3676 mg/L PBTK NA 95% Rat Human DTXSID9043853 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human -DTXSID9043853 Fup NA 0.7186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9043853 Vd NA 0.7313 L/kg 1compartment NA NA Human Human +DTXSID9043853 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9043853 Vd NA 0.5619 L/kg 1compartment NA NA Human Human DTXSID9043853 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9043853 TK.Half.Life NA 1.424 hours 1compartment NA NA Human Human -DTXSID9043853 Css NA 0.19 mg/L 3compartmentss NA 50% Human Human -DTXSID9043853 Css NA 1.441 mg/L 3compartmentss NA 95% Human Human -DTXSID9043853 Css NA 0.154 mg/L PBTK NA 50% Human Human -DTXSID9043853 Css NA 0.9433 mg/L PBTK NA 95% Human Human +DTXSID9043853 TK.Half.Life NA 1.431 hours 1compartment NA NA Human Human +DTXSID9043853 Css NA 0.1634 mg/L 3compartmentss NA 50% Human Human +DTXSID9043853 Css NA 1.223 mg/L 3compartmentss NA 95% Human Human +DTXSID9043853 Css NA 0.1236 mg/L PBTK NA 50% Human Human +DTXSID9043853 Css NA 0.7899 mg/L PBTK NA 95% Human Human DTXSID9043853 Clint 3 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human -DTXSID9043853 Fup NA 0.7186 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9043853 Vd NA 0.7474 L/kg 1compartment NA NA Rat Human +DTXSID9043853 Fup 0.527 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9043853 Vd NA 0.5819 L/kg 1compartment NA NA Rat Human DTXSID9043853 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9043853 TK.Half.Life NA 0.7747 hours 1compartment NA NA Rat Human -DTXSID9043853 Css NA 0.0839 mg/L 3compartmentss NA 50% Rat Human -DTXSID9043853 Css NA 0.5802 mg/L 3compartmentss NA 95% Rat Human -DTXSID9043853 Css NA 0.06668 mg/L PBTK NA 50% Rat Human -DTXSID9043853 Css NA 0.3469 mg/L PBTK NA 95% Rat Human -DTXSID9043855 Clint NA 0.1797 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9043855 Fup NA 0.1346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9043855 Vd NA 0.2806 L/kg 1compartment NA NA Human Human -DTXSID9043855 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9043855 TK.Half.Life NA 10.41 hours 1compartment NA NA Human Human -DTXSID9043855 Css NA 5.403 mg/L 3compartmentss NA 50% Human Human -DTXSID9043855 Css NA 25.8 mg/L 3compartmentss NA 95% Human Human -DTXSID9043855 Css NA 3.378 mg/L PBTK NA 50% Human Human -DTXSID9043855 Css NA 15.13 mg/L PBTK NA 95% Human Human -DTXSID9043855 Clint NA 0.1797 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9043855 Fup NA 0.1346 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9043855 Vd NA 0.2783 L/kg 1compartment NA NA Rat Human +DTXSID9043853 TK.Half.Life NA 0.8033 hours 1compartment NA NA Rat Human +DTXSID9043853 Css NA 0.002112 mg/L 3compartmentss NA 50% Rat Human +DTXSID9043853 Css NA 0.01883 mg/L 3compartmentss NA 95% Rat Human +DTXSID9043853 Css NA 0.001536 mg/L PBTK NA 50% Rat Human +DTXSID9043853 Css NA 0.01205 mg/L PBTK NA 95% Rat Human +DTXSID9043855 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9043855 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9043855 Vd NA 0.3002 L/kg 1compartment NA NA Human Human +DTXSID9043855 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9043855 TK.Half.Life NA 0.5771 hours 1compartment NA NA Human Human +DTXSID9043855 Css NA 0.1569 mg/L 3compartmentss NA 50% Human Human +DTXSID9043855 Css NA 1.205 mg/L 3compartmentss NA 95% Human Human +DTXSID9043855 Css NA 0.09934 mg/L PBTK NA 50% Human Human +DTXSID9043855 Css NA 0.7229 mg/L PBTK NA 95% Human Human +DTXSID9043855 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9043855 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9043855 Vd NA 0.298 L/kg 1compartment NA NA Rat Human DTXSID9043855 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9043855 TK.Half.Life NA 3.986 hours 1compartment NA NA Rat Human -DTXSID9043855 Css NA 1.775 mg/L 3compartmentss NA 50% Rat Human -DTXSID9043855 Css NA 7.005 mg/L 3compartmentss NA 95% Rat Human -DTXSID9043855 Css NA 1.035 mg/L PBTK NA 50% Rat Human -DTXSID9043855 Css NA 3.863 mg/L PBTK NA 95% Rat Human +DTXSID9043855 TK.Half.Life NA 0.3239 hours 1compartment NA NA Rat Human +DTXSID9043855 Css NA 0.02017 mg/L 3compartmentss NA 50% Rat Human +DTXSID9043855 Css NA 0.1206 mg/L 3compartmentss NA 95% Rat Human +DTXSID9043855 Css NA 0.01244 mg/L PBTK NA 50% Rat Human +DTXSID9043855 Css NA 0.0711 mg/L PBTK NA 95% Rat Human DTXSID9043938 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9043938 Fup 0.0352 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9043938 Vd NA 0.2575 L/kg 1compartment NA NA Human Human -DTXSID9043938 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID9043938 TK.Half.Life NA 47.44 hours 1compartment NA NA Human Human -DTXSID9043938 Css NA 31.6 mg/L 3compartmentss NA 50% Human Human -DTXSID9043938 Css NA 137 mg/L 3compartmentss NA 95% Human Human -DTXSID9043938 Css NA 18.81 mg/L PBTK NA 50% Human Human -DTXSID9043938 Css NA 79.22 mg/L PBTK NA 95% Human Human +DTXSID9043938 Vd NA 0.2774 L/kg 1compartment NA NA Human Human +DTXSID9043938 Days.Css NA 9 Days PBTK NA NA Human Human +DTXSID9043938 TK.Half.Life NA 51.19 hours 1compartment NA NA Human Human +DTXSID9043938 Css NA 30.15 mg/L 3compartmentss NA 50% Human Human +DTXSID9043938 Css NA 130.5 mg/L 3compartmentss NA 95% Human Human +DTXSID9043938 Css NA 18.08 mg/L PBTK NA 50% Human Human +DTXSID9043938 Css NA 76.33 mg/L PBTK NA 95% Human Human DTXSID9043938 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9043938 Fup 0.0352 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID9043938 Vd NA 0.2407 L/kg 1compartment NA NA Rat Human -DTXSID9043938 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9043938 TK.Half.Life NA 15.08 hours 1compartment NA NA Rat Human -DTXSID9043938 Css NA 8.91 mg/L 3compartmentss NA 50% Rat Human -DTXSID9043938 Css NA 31.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID9043938 Css NA 4.972 mg/L PBTK NA 50% Rat Human -DTXSID9043938 Css NA 17.4 mg/L PBTK NA 95% Rat Human -DTXSID9043988 Clint NA 698.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9043988 Fup NA 0.0082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9043988 Vd NA 2.21 L/kg 1compartment NA NA Human Human -DTXSID9043988 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9043988 TK.Half.Life NA 3.121 hours 1compartment NA NA Human Human -DTXSID9043988 Css NA 0.08694 mg/L 3compartmentss NA 50% Human Human -DTXSID9043988 Css NA 0.7178 mg/L 3compartmentss NA 95% Human Human -DTXSID9043988 Css NA 0.0561 mg/L PBTK NA 50% Human Human -DTXSID9043988 Css NA 0.4441 mg/L PBTK NA 95% Human Human -DTXSID9043988 Clint NA 698.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9043988 Fup NA 0.0082 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9043988 Vd NA 1.641 L/kg 1compartment NA NA Rat Human -DTXSID9043988 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9043988 TK.Half.Life NA 0.9746 hours 1compartment NA NA Rat Human -DTXSID9043988 Css NA 0.04989 mg/L 3compartmentss NA 50% Rat Human -DTXSID9043988 Css NA 0.3473 mg/L 3compartmentss NA 95% Rat Human -DTXSID9043988 Css NA 0.03032 mg/L PBTK NA 50% Rat Human -DTXSID9043988 Css NA 0.2041 mg/L PBTK NA 95% Rat Human -DTXSID9044112 Clint NA 11.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044112 Fup NA 0.085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044112 Vd NA 0.6116 L/kg 1compartment NA NA Human Human +DTXSID9043938 Vd NA 0.255 L/kg 1compartment NA NA Rat Human +DTXSID9043938 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9043938 TK.Half.Life NA 15.98 hours 1compartment NA NA Rat Human +DTXSID9043938 Css NA 1.65 mg/L 3compartmentss NA 50% Rat Human +DTXSID9043938 Css NA 6.409 mg/L 3compartmentss NA 95% Rat Human +DTXSID9043938 Css NA 0.9554 mg/L PBTK NA 50% Rat Human +DTXSID9043938 Css NA 3.618 mg/L PBTK NA 95% Rat Human +DTXSID9043988 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9043988 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9043988 Vd NA 2.804 L/kg 1compartment NA NA Human Human +DTXSID9043988 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9043988 TK.Half.Life NA 38.59 hours 1compartment NA NA Human Human +DTXSID9043988 Css NA 1.576 mg/L 3compartmentss NA 50% Human Human +DTXSID9043988 Css NA 10.7 mg/L 3compartmentss NA 95% Human Human +DTXSID9043988 Css NA 1.064 mg/L PBTK NA 50% Human Human +DTXSID9043988 Css NA 6.915 mg/L PBTK NA 95% Human Human +DTXSID9043988 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9043988 Fup 0.0258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9043988 Vd NA 2.099 L/kg 1compartment NA NA Rat Human +DTXSID9043988 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9043988 TK.Half.Life NA 7.605 hours 1compartment NA NA Rat Human +DTXSID9043988 Css NA 0.07988 mg/L 3compartmentss NA 50% Rat Human +DTXSID9043988 Css NA 0.5788 mg/L 3compartmentss NA 95% Rat Human +DTXSID9043988 Css NA 0.05248 mg/L PBTK NA 50% Rat Human +DTXSID9043988 Css NA 0.3628 mg/L PBTK NA 95% Rat Human +DTXSID9044112 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044112 Fup 0.0615 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044112 Vd NA 0.7483 L/kg 1compartment NA NA Human Human DTXSID9044112 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044112 TK.Half.Life NA 2.721 hours 1compartment NA NA Human Human -DTXSID9044112 Css NA 0.6192 mg/L 3compartmentss NA 50% Human Human -DTXSID9044112 Css NA 4.595 mg/L 3compartmentss NA 95% Human Human -DTXSID9044112 Css NA 0.3903 mg/L PBTK NA 50% Human Human -DTXSID9044112 Css NA 2.791 mg/L PBTK NA 95% Human Human -DTXSID9044112 Clint NA 11.87 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044112 Fup NA 0.085 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044112 Vd NA 0.5065 L/kg 1compartment NA NA Rat Human +DTXSID9044112 TK.Half.Life NA 7.42 hours 1compartment NA NA Human Human +DTXSID9044112 Css NA 1.609 mg/L 3compartmentss NA 50% Human Human +DTXSID9044112 Css NA 11.09 mg/L 3compartmentss NA 95% Human Human +DTXSID9044112 Css NA 0.9942 mg/L PBTK NA 50% Human Human +DTXSID9044112 Css NA 6.545 mg/L PBTK NA 95% Human Human +DTXSID9044112 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044112 Fup 0.0615 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044112 Vd NA 0.59 L/kg 1compartment NA NA Rat Human DTXSID9044112 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044112 TK.Half.Life NA 1.358 hours 1compartment NA NA Rat Human -DTXSID9044112 Css NA 0.343 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044112 Css NA 1.923 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044112 Css NA 0.2021 mg/L PBTK NA 50% Rat Human -DTXSID9044112 Css NA 1.082 mg/L PBTK NA 95% Rat Human -DTXSID9044164 Clint NA 63.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044164 Fup NA 0.0701 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044164 Vd NA 2.854 L/kg 1compartment NA NA Human Human -DTXSID9044164 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044164 TK.Half.Life NA 9.956 hours 1compartment NA NA Human Human -DTXSID9044164 Css NA 0.3579 mg/L 3compartmentss NA 50% Human Human -DTXSID9044164 Css NA 2.307 mg/L 3compartmentss NA 95% Human Human -DTXSID9044164 Css NA 0.246 mg/L PBTK NA 50% Human Human -DTXSID9044164 Css NA 1.521 mg/L PBTK NA 95% Human Human -DTXSID9044164 Clint NA 63.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044164 Fup NA 0.0701 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044164 Vd NA 2.142 L/kg 1compartment NA NA Rat Human -DTXSID9044164 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044164 TK.Half.Life NA 2.154 hours 1compartment NA NA Rat Human -DTXSID9044164 Css NA 0.1995 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044164 Css NA 1.059 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044164 Css NA 0.1316 mg/L PBTK NA 50% Rat Human -DTXSID9044164 Css NA 0.6785 mg/L PBTK NA 95% Rat Human -DTXSID9044241 Clint NA 0.1684 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044241 Fup NA 0.2629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044241 Vd NA 0.4619 L/kg 1compartment NA NA Human Human +DTXSID9044112 TK.Half.Life NA 3.466 hours 1compartment NA NA Rat Human +DTXSID9044112 Css NA 0.1982 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044112 Css NA 1.024 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044112 Css NA 0.1194 mg/L PBTK NA 50% Rat Human +DTXSID9044112 Css NA 0.5906 mg/L PBTK NA 95% Rat Human +DTXSID9044164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044164 Fup 0.0245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044164 Vd NA 2.438 L/kg 1compartment NA NA Human Human +DTXSID9044164 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9044164 TK.Half.Life NA 26.07 hours 1compartment NA NA Human Human +DTXSID9044164 Css NA 1.466 mg/L 3compartmentss NA 50% Human Human +DTXSID9044164 Css NA 11.14 mg/L 3compartmentss NA 95% Human Human +DTXSID9044164 Css NA 0.9716 mg/L PBTK NA 50% Human Human +DTXSID9044164 Css NA 7.091 mg/L PBTK NA 95% Human Human +DTXSID9044164 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044164 Fup 0.0245 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044164 Vd NA 1.82 L/kg 1compartment NA NA Rat Human +DTXSID9044164 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9044164 TK.Half.Life NA 6.73 hours 1compartment NA NA Rat Human +DTXSID9044164 Css NA 0.1912 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044164 Css NA 1.162 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044164 Css NA 0.1239 mg/L PBTK NA 50% Rat Human +DTXSID9044164 Css NA 0.7256 mg/L PBTK NA 95% Rat Human +DTXSID9044241 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044241 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044241 Vd NA 0.5721 L/kg 1compartment NA NA Human Human DTXSID9044241 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044241 TK.Half.Life NA 8.923 hours 1compartment NA NA Human Human -DTXSID9044241 Css NA 2.174 mg/L 3compartmentss NA 50% Human Human -DTXSID9044241 Css NA 8.763 mg/L 3compartmentss NA 95% Human Human -DTXSID9044241 Css NA 1.54 mg/L PBTK NA 50% Human Human -DTXSID9044241 Css NA 5.541 mg/L PBTK NA 95% Human Human -DTXSID9044241 Clint NA 0.1684 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044241 Fup NA 0.2629 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044241 Vd NA 0.4533 L/kg 1compartment NA NA Rat Human +DTXSID9044241 TK.Half.Life NA 9.476 hours 1compartment NA NA Human Human +DTXSID9044241 Css NA 1.704 mg/L 3compartmentss NA 50% Human Human +DTXSID9044241 Css NA 7.835 mg/L 3compartmentss NA 95% Human Human +DTXSID9044241 Css NA 1.312 mg/L PBTK NA 50% Human Human +DTXSID9044241 Css NA 5.044 mg/L PBTK NA 95% Human Human +DTXSID9044241 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044241 Fup 0.392 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044241 Vd NA 0.5633 L/kg 1compartment NA NA Rat Human DTXSID9044241 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044241 TK.Half.Life NA 3.352 hours 1compartment NA NA Rat Human -DTXSID9044241 Css NA 0.6947 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044241 Css NA 2.285 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044241 Css NA 0.4676 mg/L PBTK NA 50% Rat Human -DTXSID9044241 Css NA 1.345 mg/L PBTK NA 95% Rat Human +DTXSID9044241 TK.Half.Life NA 3.172 hours 1compartment NA NA Rat Human +DTXSID9044241 Css NA 0.1089 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044241 Css NA 0.4102 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044241 Css NA 0.08328 mg/L PBTK NA 50% Rat Human +DTXSID9044241 Css NA 0.2568 mg/L PBTK NA 95% Rat Human DTXSID9044247 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9044247 Fup NA 0.8952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044247 Vd NA 0.6387 L/kg 1compartment NA NA Human Human +DTXSID9044247 Vd NA 0.6277 L/kg 1compartment NA NA Human Human DTXSID9044247 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044247 TK.Half.Life NA 4.615 hours 1compartment NA NA Human Human -DTXSID9044247 Css NA 0.9139 mg/L 3compartmentss NA 50% Human Human -DTXSID9044247 Css NA 3.502 mg/L 3compartmentss NA 95% Human Human -DTXSID9044247 Css NA 0.736 mg/L PBTK NA 50% Human Human -DTXSID9044247 Css NA 2.4 mg/L PBTK NA 95% Human Human +DTXSID9044247 TK.Half.Life NA 4.536 hours 1compartment NA NA Human Human +DTXSID9044247 Css NA 0.784 mg/L 3compartmentss NA 50% Human Human +DTXSID9044247 Css NA 3.034 mg/L 3compartmentss NA 95% Human Human +DTXSID9044247 Css NA 0.6315 mg/L PBTK NA 50% Human Human +DTXSID9044247 Css NA 2.079 mg/L PBTK NA 95% Human Human DTXSID9044247 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9044247 Fup NA 0.8952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044247 Vd NA 0.6885 L/kg 1compartment NA NA Rat Human +DTXSID9044247 Vd NA 0.6807 L/kg 1compartment NA NA Rat Human DTXSID9044247 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044247 TK.Half.Life NA 1.696 hours 1compartment NA NA Rat Human -DTXSID9044247 Css NA 0.2371 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044247 Css NA 0.8454 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044247 Css NA 0.1858 mg/L PBTK NA 50% Rat Human -DTXSID9044247 Css NA 0.5289 mg/L PBTK NA 95% Rat Human -DTXSID9044299 Clint NA 12.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9044247 TK.Half.Life NA 1.677 hours 1compartment NA NA Rat Human +DTXSID9044247 Css NA 0.01422 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044247 Css NA 0.07586 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044247 Css NA 0.011 mg/L PBTK NA 50% Rat Human +DTXSID9044247 Css NA 0.05297 mg/L PBTK NA 95% Rat Human +DTXSID9044297 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044297 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9044297 Vd NA 0.6272 L/kg 1compartment NA NA Human Human +DTXSID9044297 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044297 TK.Half.Life NA 2.951 hours 1compartment NA NA Human Human +DTXSID9044297 Css NA 0.6662 mg/L 3compartmentss NA 50% Human Human +DTXSID9044297 Css NA 7.007 mg/L 3compartmentss NA 95% Human Human +DTXSID9044297 Css NA 0.4236 mg/L PBTK NA 50% Human Human +DTXSID9044297 Css NA 4.184 mg/L PBTK NA 95% Human Human +DTXSID9044297 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044297 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9044297 Vd NA 0.5982 L/kg 1compartment NA NA Rat Human +DTXSID9044297 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9044297 TK.Half.Life NA 1.812 hours 1compartment NA NA Rat Human +DTXSID9044297 Css NA 0.08812 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044297 Css NA 0.8073 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044297 Css NA 0.05432 mg/L PBTK NA 50% Rat Human +DTXSID9044297 Css NA 0.4649 mg/L PBTK NA 95% Rat Human +DTXSID9044299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9044299 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9044299 Vd NA 0.3286 L/kg 1compartment NA NA Human Human +DTXSID9044299 Vd NA 0.2577 L/kg 1compartment NA NA Human Human DTXSID9044299 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044299 TK.Half.Life NA 2.227 hours 1compartment NA NA Human Human -DTXSID9044299 Css NA 1.097 mg/L 3compartmentss NA 50% Human Human -DTXSID9044299 Css NA 8.526 mg/L 3compartmentss NA 95% Human Human -DTXSID9044299 Css NA 0.6548 mg/L PBTK NA 50% Human Human -DTXSID9044299 Css NA 4.948 mg/L PBTK NA 95% Human Human -DTXSID9044299 Clint NA 12.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9044299 TK.Half.Life NA 1.126 hours 1compartment NA NA Human Human +DTXSID9044299 Css NA 0.5417 mg/L 3compartmentss NA 50% Human Human +DTXSID9044299 Css NA 4.703 mg/L 3compartmentss NA 95% Human Human +DTXSID9044299 Css NA 0.3251 mg/L PBTK NA 50% Human Human +DTXSID9044299 Css NA 2.766 mg/L PBTK NA 95% Human Human +DTXSID9044299 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9044299 Fup 0.05 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9044299 Vd NA 0.2866 L/kg 1compartment NA NA Rat Human +DTXSID9044299 Vd NA 0.2394 L/kg 1compartment NA NA Rat Human DTXSID9044299 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044299 TK.Half.Life NA 1.226 hours 1compartment NA NA Rat Human -DTXSID9044299 Css NA 0.6034 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044299 Css NA 3.736 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044299 Css NA 0.3375 mg/L PBTK NA 50% Rat Human -DTXSID9044299 Css NA 2.04 mg/L PBTK NA 95% Rat Human +DTXSID9044299 TK.Half.Life NA 0.6545 hours 1compartment NA NA Rat Human +DTXSID9044299 Css NA 0.02662 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044299 Css NA 0.2596 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044299 Css NA 0.01518 mg/L PBTK NA 50% Rat Human +DTXSID9044299 Css NA 0.1461 mg/L PBTK NA 95% Rat Human DTXSID9044320 Clint NA 0.3685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9044320 Fup NA 0.7435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044320 Vd NA 1.687 L/kg 1compartment NA NA Human Human +DTXSID9044320 Vd NA 1.732 L/kg 1compartment NA NA Human Human DTXSID9044320 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044320 TK.Half.Life NA 9.215 hours 1compartment NA NA Human Human -DTXSID9044320 Css NA 0.5289 mg/L 3compartmentss NA 50% Human Human -DTXSID9044320 Css NA 3.764 mg/L 3compartmentss NA 95% Human Human -DTXSID9044320 Css NA 0.5178 mg/L PBTK NA 50% Human Human -DTXSID9044320 Css NA 2.581 mg/L PBTK NA 95% Human Human +DTXSID9044320 TK.Half.Life NA 9.46 hours 1compartment NA NA Human Human +DTXSID9044320 Css NA 0.4432 mg/L 3compartmentss NA 50% Human Human +DTXSID9044320 Css NA 3.076 mg/L 3compartmentss NA 95% Human Human +DTXSID9044320 Css NA 0.4384 mg/L PBTK NA 50% Human Human +DTXSID9044320 Css NA 2.139 mg/L PBTK NA 95% Human Human DTXSID9044320 Clint NA 0.3685 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9044320 Fup NA 0.7435 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044320 Vd NA 1.671 L/kg 1compartment NA NA Rat Human +DTXSID9044320 Vd NA 1.716 L/kg 1compartment NA NA Rat Human DTXSID9044320 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044320 TK.Half.Life NA 3.836 hours 1compartment NA NA Rat Human -DTXSID9044320 Css NA 0.1683 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044320 Css NA 1.268 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044320 Css NA 0.1631 mg/L PBTK NA 50% Rat Human -DTXSID9044320 Css NA 0.7956 mg/L PBTK NA 95% Rat Human -DTXSID9044322 Clint NA 36.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044322 Fup NA 0.1489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044322 Vd NA 4.053 L/kg 1compartment NA NA Human Human -DTXSID9044322 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044322 TK.Half.Life NA 2.081 hours 1compartment NA NA Human Human -DTXSID9044322 Css NA 0.01003 mg/L 3compartmentss NA 50% Human Human -DTXSID9044322 Css NA 0.1089 mg/L 3compartmentss NA 95% Human Human -DTXSID9044322 Css NA 0.01322 mg/L PBTK NA 50% Human Human -DTXSID9044322 Css NA 0.1016 mg/L PBTK NA 95% Human Human -DTXSID9044322 Clint NA 36.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044322 Fup NA 0.1489 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044322 Vd NA 3.967 L/kg 1compartment NA NA Rat Human -DTXSID9044322 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044322 TK.Half.Life NA 0.9867 hours 1compartment NA NA Rat Human -DTXSID9044322 Css NA 0.005421 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044322 Css NA 0.04556 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044322 Css NA 0.007116 mg/L PBTK NA 50% Rat Human -DTXSID9044322 Css NA 0.04427 mg/L PBTK NA 95% Rat Human -DTXSID9044328 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044328 Fup NA 0.236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044328 Vd NA 0.6078 L/kg 1compartment NA NA Human Human +DTXSID9044320 TK.Half.Life NA 3.938 hours 1compartment NA NA Rat Human +DTXSID9044320 Css NA 0.01058 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044320 Css NA 0.09041 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044320 Css NA 0.01018 mg/L PBTK NA 50% Rat Human +DTXSID9044320 Css NA 0.06478 mg/L PBTK NA 95% Rat Human +DTXSID9044328 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044328 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044328 Vd NA 0.7054 L/kg 1compartment NA NA Human Human DTXSID9044328 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9044328 TK.Half.Life NA 16.68 hours 1compartment NA NA Human Human -DTXSID9044328 Css NA 3.242 mg/L 3compartmentss NA 50% Human Human -DTXSID9044328 Css NA 12.36 mg/L 3compartmentss NA 95% Human Human -DTXSID9044328 Css NA 2.237 mg/L PBTK NA 50% Human Human -DTXSID9044328 Css NA 7.678 mg/L PBTK NA 95% Human Human -DTXSID9044328 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044328 Fup NA 0.236 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044328 Vd NA 0.6076 L/kg 1compartment NA NA Rat Human +DTXSID9044328 TK.Half.Life NA 19.88 hours 1compartment NA NA Human Human +DTXSID9044328 Css NA 2.77 mg/L 3compartmentss NA 50% Human Human +DTXSID9044328 Css NA 10.85 mg/L 3compartmentss NA 95% Human Human +DTXSID9044328 Css NA 1.955 mg/L PBTK NA 50% Human Human +DTXSID9044328 Css NA 6.905 mg/L PBTK NA 95% Human Human +DTXSID9044328 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044328 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044328 Vd NA 0.7006 L/kg 1compartment NA NA Rat Human DTXSID9044328 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044328 TK.Half.Life NA 5.677 hours 1compartment NA NA Rat Human -DTXSID9044328 Css NA 0.9082 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044328 Css NA 2.872 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044328 Css NA 0.5933 mg/L PBTK NA 50% Rat Human -DTXSID9044328 Css NA 1.666 mg/L PBTK NA 95% Rat Human -DTXSID9044370 Clint NA 16.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044370 Fup NA 0.1503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044370 Vd NA 2.787 L/kg 1compartment NA NA Human Human -DTXSID9044370 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9044370 TK.Half.Life NA 16.05 hours 1compartment NA NA Human Human -DTXSID9044370 Css NA 0.6452 mg/L 3compartmentss NA 50% Human Human -DTXSID9044370 Css NA 4.034 mg/L 3compartmentss NA 95% Human Human -DTXSID9044370 Css NA 0.4556 mg/L PBTK NA 50% Human Human -DTXSID9044370 Css NA 2.718 mg/L PBTK NA 95% Human Human -DTXSID9044370 Clint NA 16.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044370 Fup NA 0.1503 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044370 Vd NA 2.105 L/kg 1compartment NA NA Rat Human +DTXSID9044328 TK.Half.Life NA 6.717 hours 1compartment NA NA Rat Human +DTXSID9044328 Css NA 0.06729 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044328 Css NA 0.36 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044328 Css NA 0.04624 mg/L PBTK NA 50% Rat Human +DTXSID9044328 Css NA 0.2252 mg/L PBTK NA 95% Rat Human +DTXSID9044370 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044370 Fup 0.081 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044370 Vd NA 2.52 L/kg 1compartment NA NA Human Human +DTXSID9044370 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044370 TK.Half.Life NA 13.1 hours 1compartment NA NA Human Human +DTXSID9044370 Css NA 0.6032 mg/L 3compartmentss NA 50% Human Human +DTXSID9044370 Css NA 4.056 mg/L 3compartmentss NA 95% Human Human +DTXSID9044370 Css NA 0.4107 mg/L PBTK NA 50% Human Human +DTXSID9044370 Css NA 2.679 mg/L PBTK NA 95% Human Human +DTXSID9044370 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044370 Fup 0.081 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044370 Vd NA 1.896 L/kg 1compartment NA NA Rat Human DTXSID9044370 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044370 TK.Half.Life NA 3.45 hours 1compartment NA NA Rat Human -DTXSID9044370 Css NA 0.3531 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044370 Css NA 1.701 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044370 Css NA 0.2377 mg/L PBTK NA 50% Rat Human -DTXSID9044370 Css NA 1.109 mg/L PBTK NA 95% Rat Human +DTXSID9044370 TK.Half.Life NA 3.363 hours 1compartment NA NA Rat Human +DTXSID9044370 Css NA 0.07803 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044370 Css NA 0.4026 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044370 Css NA 0.05258 mg/L PBTK NA 50% Rat Human +DTXSID9044370 Css NA 0.2629 mg/L PBTK NA 95% Rat Human DTXSID9044372 Clint NA 550.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9044372 Fup NA 0.2551 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044372 Vd NA 2.225 L/kg 1compartment NA NA Human Human +DTXSID9044372 Vd NA 2.314 L/kg 1compartment NA NA Human Human DTXSID9044372 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044372 TK.Half.Life NA 1.763 hours 1compartment NA NA Human Human -DTXSID9044372 Css NA 0.00571 mg/L 3compartmentss NA 50% Human Human -DTXSID9044372 Css NA 0.04128 mg/L 3compartmentss NA 95% Human Human -DTXSID9044372 Css NA 0.004268 mg/L PBTK NA 50% Human Human -DTXSID9044372 Css NA 0.02876 mg/L PBTK NA 95% Human Human +DTXSID9044372 TK.Half.Life NA 1.846 hours 1compartment NA NA Human Human +DTXSID9044372 Css NA 0.004426 mg/L 3compartmentss NA 50% Human Human +DTXSID9044372 Css NA 0.04036 mg/L 3compartmentss NA 95% Human Human +DTXSID9044372 Css NA 0.003274 mg/L PBTK NA 50% Human Human +DTXSID9044372 Css NA 0.02826 mg/L PBTK NA 95% Human Human DTXSID9044372 Clint NA 550.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9044372 Fup NA 0.2551 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044372 Vd NA 1.718 L/kg 1compartment NA NA Rat Human +DTXSID9044372 Vd NA 1.782 L/kg 1compartment NA NA Rat Human DTXSID9044372 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044372 TK.Half.Life NA 0.5864 hours 1compartment NA NA Rat Human -DTXSID9044372 Css NA 0.003211 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044372 Css NA 0.01891 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044372 Css NA 0.002293 mg/L PBTK NA 50% Rat Human -DTXSID9044372 Css NA 0.01261 mg/L PBTK NA 95% Rat Human -DTXSID9044374 Clint NA 6.487 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044374 Fup NA 0.4114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044374 Vd NA 1.722 L/kg 1compartment NA NA Human Human -DTXSID9044374 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044374 TK.Half.Life NA 3.936 hours 1compartment NA NA Human Human -DTXSID9044374 Css NA 0.1907 mg/L 3compartmentss NA 50% Human Human -DTXSID9044374 Css NA 1.169 mg/L 3compartmentss NA 95% Human Human -DTXSID9044374 Css NA 0.1537 mg/L PBTK NA 50% Human Human -DTXSID9044374 Css NA 0.8281 mg/L PBTK NA 95% Human Human -DTXSID9044374 Clint NA 6.487 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044374 Fup NA 0.4114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044374 Vd NA 1.401 L/kg 1compartment NA NA Rat Human -DTXSID9044374 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044374 TK.Half.Life NA 1.525 hours 1compartment NA NA Rat Human -DTXSID9044374 Css NA 0.09566 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044374 Css NA 0.4508 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044374 Css NA 0.07436 mg/L PBTK NA 50% Rat Human -DTXSID9044374 Css NA 0.3036 mg/L PBTK NA 95% Rat Human -DTXSID9044378 Clint NA 0.5316 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044378 Fup NA 0.1103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044378 Vd NA 0.3779 L/kg 1compartment NA NA Human Human -DTXSID9044378 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9044378 TK.Half.Life NA 11.86 hours 1compartment NA NA Human Human -DTXSID9044378 Css NA 4.686 mg/L 3compartmentss NA 50% Human Human -DTXSID9044378 Css NA 23.79 mg/L 3compartmentss NA 95% Human Human -DTXSID9044378 Css NA 2.939 mg/L PBTK NA 50% Human Human -DTXSID9044378 Css NA 13.95 mg/L PBTK NA 95% Human Human -DTXSID9044378 Clint NA 0.5316 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044378 Fup NA 0.1103 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044378 Vd NA 0.3452 L/kg 1compartment NA NA Rat Human +DTXSID9044372 TK.Half.Life NA 0.6102 hours 1compartment NA NA Rat Human +DTXSID9044372 Css NA 0.0005992 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044372 Css NA 0.004339 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044372 Css NA 0.000448 mg/L PBTK NA 50% Rat Human +DTXSID9044372 Css NA 0.002984 mg/L PBTK NA 95% Rat Human +DTXSID9044378 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044378 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044378 Vd NA 2.813 L/kg 1compartment NA NA Human Human +DTXSID9044378 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044378 TK.Half.Life NA 13.04 hours 1compartment NA NA Human Human +DTXSID9044378 Css NA 0.4792 mg/L 3compartmentss NA 50% Human Human +DTXSID9044378 Css NA 3.166 mg/L 3compartmentss NA 95% Human Human +DTXSID9044378 Css NA 0.3372 mg/L PBTK NA 50% Human Human +DTXSID9044378 Css NA 2.169 mg/L PBTK NA 95% Human Human +DTXSID9044378 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044378 Fup 0.156 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044378 Vd NA 2.123 L/kg 1compartment NA NA Rat Human DTXSID9044378 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044378 TK.Half.Life NA 4.83 hours 1compartment NA NA Rat Human -DTXSID9044378 Css NA 1.792 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044378 Css NA 7.457 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044378 Css NA 1.052 mg/L PBTK NA 50% Rat Human -DTXSID9044378 Css NA 4.113 mg/L PBTK NA 95% Rat Human -DTXSID9044401 Clint NA 1.658 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044401 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044401 Vd NA 1.97 L/kg 1compartment NA NA Human Human +DTXSID9044378 TK.Half.Life NA 2.814 hours 1compartment NA NA Rat Human +DTXSID9044378 Css NA 0.06088 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044378 Css NA 0.3051 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044378 Css NA 0.04256 mg/L PBTK NA 50% Rat Human +DTXSID9044378 Css NA 0.2104 mg/L PBTK NA 95% Rat Human +DTXSID9044401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044401 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044401 Vd NA 1.004 L/kg 1compartment NA NA Human Human DTXSID9044401 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044401 TK.Half.Life NA 3.849 hours 1compartment NA NA Human Human -DTXSID9044401 Css NA 0.1859 mg/L 3compartmentss NA 50% Human Human -DTXSID9044401 Css NA 1.472 mg/L 3compartmentss NA 95% Human Human -DTXSID9044401 Css NA 0.1906 mg/L PBTK NA 50% Human Human -DTXSID9044401 Css NA 1.093 mg/L PBTK NA 95% Human Human -DTXSID9044401 Clint NA 1.658 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044401 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044401 Vd NA 1.949 L/kg 1compartment NA NA Rat Human +DTXSID9044401 TK.Half.Life NA 1.082 hours 1compartment NA NA Human Human +DTXSID9044401 Css NA 0.04548 mg/L 3compartmentss NA 50% Human Human +DTXSID9044401 Css NA 0.3722 mg/L 3compartmentss NA 95% Human Human +DTXSID9044401 Css NA 0.03627 mg/L PBTK NA 50% Human Human +DTXSID9044401 Css NA 0.2619 mg/L PBTK NA 95% Human Human +DTXSID9044401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044401 Fup 0.395 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044401 Vd NA 0.9851 L/kg 1compartment NA NA Rat Human DTXSID9044401 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044401 TK.Half.Life NA 1.956 hours 1compartment NA NA Rat Human -DTXSID9044401 Css NA 0.07336 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044401 Css NA 0.5307 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044401 Css NA 0.07642 mg/L PBTK NA 50% Rat Human -DTXSID9044401 Css NA 0.3526 mg/L PBTK NA 95% Rat Human -DTXSID9044403 Clint NA 33.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044403 Fup NA 0.2393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044403 Vd NA 1.587 L/kg 1compartment NA NA Human Human +DTXSID9044401 TK.Half.Life NA 0.5536 hours 1compartment NA NA Rat Human +DTXSID9044401 Css NA 0.005608 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044401 Css NA 0.03562 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044401 Css NA 0.004517 mg/L PBTK NA 50% Rat Human +DTXSID9044401 Css NA 0.02477 mg/L PBTK NA 95% Rat Human +DTXSID9044403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044403 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044403 Vd NA 1.202 L/kg 1compartment NA NA Human Human DTXSID9044403 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044403 TK.Half.Life NA 2.102 hours 1compartment NA NA Human Human -DTXSID9044403 Css NA 0.07134 mg/L 3compartmentss NA 50% Human Human -DTXSID9044403 Css NA 0.4996 mg/L 3compartmentss NA 95% Human Human -DTXSID9044403 Css NA 0.05268 mg/L PBTK NA 50% Human Human -DTXSID9044403 Css NA 0.3395 mg/L PBTK NA 95% Human Human -DTXSID9044403 Clint NA 33.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044403 Fup NA 0.2393 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044403 Vd NA 1.258 L/kg 1compartment NA NA Rat Human +DTXSID9044403 TK.Half.Life NA 2.37 hours 1compartment NA NA Human Human +DTXSID9044403 Css NA 0.1618 mg/L 3compartmentss NA 50% Human Human +DTXSID9044403 Css NA 1.208 mg/L 3compartmentss NA 95% Human Human +DTXSID9044403 Css NA 0.111 mg/L PBTK NA 50% Human Human +DTXSID9044403 Css NA 0.7721 mg/L PBTK NA 95% Human Human +DTXSID9044403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044403 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044403 Vd NA 0.9556 L/kg 1compartment NA NA Rat Human DTXSID9044403 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044403 TK.Half.Life NA 0.7964 hours 1compartment NA NA Rat Human -DTXSID9044403 Css NA 0.03954 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044403 Css NA 0.2117 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044403 Css NA 0.02786 mg/L PBTK NA 50% Rat Human -DTXSID9044403 Css NA 0.1374 mg/L PBTK NA 95% Rat Human +DTXSID9044403 TK.Half.Life NA 0.9913 hours 1compartment NA NA Rat Human +DTXSID9044403 Css NA 0.02078 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044403 Css NA 0.1216 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044403 Css NA 0.01404 mg/L PBTK NA 50% Rat Human +DTXSID9044403 Css NA 0.07658 mg/L PBTK NA 95% Rat Human DTXSID9044405 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9044405 Fup NA 0.889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044405 Vd NA 1.713 L/kg 1compartment NA NA Human Human -DTXSID9044405 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9044405 TK.Half.Life NA 12.47 hours 1compartment NA NA Human Human -DTXSID9044405 Css NA 0.7824 mg/L 3compartmentss NA 50% Human Human -DTXSID9044405 Css NA 4.877 mg/L 3compartmentss NA 95% Human Human -DTXSID9044405 Css NA 0.767 mg/L PBTK NA 50% Human Human -DTXSID9044405 Css NA 3.424 mg/L PBTK NA 95% Human Human +DTXSID9044405 Vd NA 1.204 L/kg 1compartment NA NA Human Human +DTXSID9044405 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044405 TK.Half.Life NA 8.762 hours 1compartment NA NA Human Human +DTXSID9044405 Css NA 0.7091 mg/L 3compartmentss NA 50% Human Human +DTXSID9044405 Css NA 4.266 mg/L 3compartmentss NA 95% Human Human +DTXSID9044405 Css NA 0.6563 mg/L PBTK NA 50% Human Human +DTXSID9044405 Css NA 2.879 mg/L PBTK NA 95% Human Human DTXSID9044405 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9044405 Fup NA 0.889 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044405 Vd NA 1.751 L/kg 1compartment NA NA Rat Human +DTXSID9044405 Vd NA 1.271 L/kg 1compartment NA NA Rat Human DTXSID9044405 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044405 TK.Half.Life NA 4.343 hours 1compartment NA NA Rat Human -DTXSID9044405 Css NA 0.1972 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044405 Css NA 1.236 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044405 Css NA 0.1916 mg/L PBTK NA 50% Rat Human -DTXSID9044405 Css NA 0.796 mg/L PBTK NA 95% Rat Human -DTXSID9044407 Clint NA 1.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044407 Fup NA 0.9411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044407 Vd NA 0.9207 L/kg 1compartment NA NA Human Human +DTXSID9044405 TK.Half.Life NA 3.152 hours 1compartment NA NA Rat Human +DTXSID9044405 Css NA 0.01316 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044405 Css NA 0.1026 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044405 Css NA 0.01184 mg/L PBTK NA 50% Rat Human +DTXSID9044405 Css NA 0.07084 mg/L PBTK NA 95% Rat Human +DTXSID9044407 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044407 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044407 Vd NA 0.6184 L/kg 1compartment NA NA Human Human DTXSID9044407 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044407 TK.Half.Life NA 1.871 hours 1compartment NA NA Human Human -DTXSID9044407 Css NA 0.2142 mg/L 3compartmentss NA 50% Human Human -DTXSID9044407 Css NA 0.9404 mg/L 3compartmentss NA 95% Human Human -DTXSID9044407 Css NA 0.1828 mg/L PBTK NA 50% Human Human -DTXSID9044407 Css NA 0.7099 mg/L PBTK NA 95% Human Human -DTXSID9044407 Clint NA 1.829 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044407 Fup NA 0.9411 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044407 Vd NA 0.9314 L/kg 1compartment NA NA Rat Human +DTXSID9044407 TK.Half.Life NA 7.538 hours 1compartment NA NA Human Human +DTXSID9044407 Css NA 1.354 mg/L 3compartmentss NA 50% Human Human +DTXSID9044407 Css NA 7.874 mg/L 3compartmentss NA 95% Human Human +DTXSID9044407 Css NA 1.043 mg/L PBTK NA 50% Human Human +DTXSID9044407 Css NA 4.973 mg/L PBTK NA 95% Human Human +DTXSID9044407 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044407 Fup 0.532 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044407 Vd NA 0.6297 L/kg 1compartment NA NA Rat Human DTXSID9044407 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044407 TK.Half.Life NA 0.965 hours 1compartment NA NA Rat Human -DTXSID9044407 Css NA 0.08755 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044407 Css NA 0.3258 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044407 Css NA 0.07475 mg/L PBTK NA 50% Rat Human -DTXSID9044407 Css NA 0.2214 mg/L PBTK NA 95% Rat Human -DTXSID9044451 Clint NA 0.05075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044451 Fup NA 0.4779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044451 Vd NA 0.3981 L/kg 1compartment NA NA Human Human +DTXSID9044407 TK.Half.Life NA 2.611 hours 1compartment NA NA Rat Human +DTXSID9044407 Css NA 0.0834 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044407 Css NA 0.4372 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044407 Css NA 0.06386 mg/L PBTK NA 50% Rat Human +DTXSID9044407 Css NA 0.2663 mg/L PBTK NA 95% Rat Human +DTXSID9044451 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044451 Fup 0.826 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044451 Vd NA 0.5467 L/kg 1compartment NA NA Human Human DTXSID9044451 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044451 TK.Half.Life NA 4.965 hours 1compartment NA NA Human Human -DTXSID9044451 Css NA 1.475 mg/L 3compartmentss NA 50% Human Human -DTXSID9044451 Css NA 6.985 mg/L 3compartmentss NA 95% Human Human -DTXSID9044451 Css NA 1.044 mg/L PBTK NA 50% Human Human -DTXSID9044451 Css NA 4.302 mg/L PBTK NA 95% Human Human -DTXSID9044451 Clint NA 0.05075 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044451 Fup NA 0.4779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044451 Vd NA 0.4074 L/kg 1compartment NA NA Rat Human +DTXSID9044451 TK.Half.Life NA 4.281 hours 1compartment NA NA Human Human +DTXSID9044451 Css NA 1.006 mg/L 3compartmentss NA 50% Human Human +DTXSID9044451 Css NA 5.842 mg/L 3compartmentss NA 95% Human Human +DTXSID9044451 Css NA 0.7784 mg/L PBTK NA 50% Human Human +DTXSID9044451 Css NA 3.657 mg/L PBTK NA 95% Human Human +DTXSID9044451 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044451 Fup 0.826 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044451 Vd NA 0.5599 L/kg 1compartment NA NA Rat Human DTXSID9044451 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044451 TK.Half.Life NA 1.805 hours 1compartment NA NA Rat Human -DTXSID9044451 Css NA 0.424 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044451 Css NA 1.777 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044451 Css NA 0.2852 mg/L PBTK NA 50% Rat Human -DTXSID9044451 Css NA 1.025 mg/L PBTK NA 95% Rat Human -DTXSID9044455 Clint NA 0.8921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044455 Fup NA 0.1261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044455 Vd NA 2.555 L/kg 1compartment NA NA Human Human -DTXSID9044455 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID9044455 TK.Half.Life NA 137.9 hours 1compartment NA NA Human Human -DTXSID9044455 Css NA 6.973 mg/L 3compartmentss NA 50% Human Human -DTXSID9044455 Css NA 26.28 mg/L 3compartmentss NA 95% Human Human -DTXSID9044455 Css NA 4.868 mg/L PBTK NA 50% Human Human -DTXSID9044455 Css NA 17.08 mg/L PBTK NA 95% Human Human -DTXSID9044455 Clint NA 0.8921 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044455 Fup NA 0.1261 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044455 Vd NA 1.93 L/kg 1compartment NA NA Rat Human -DTXSID9044455 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID9044455 TK.Half.Life NA 25.66 hours 1compartment NA NA Rat Human -DTXSID9044455 Css NA 2.928 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044455 Css NA 8.253 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044455 Css NA 1.958 mg/L PBTK NA 50% Rat Human -DTXSID9044455 Css NA 4.962 mg/L PBTK NA 95% Rat Human -DTXSID9044459 Clint NA 2.561 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9044451 TK.Half.Life NA 1.494 hours 1compartment NA NA Rat Human +DTXSID9044451 Css NA 0.0603 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044451 Css NA 0.3306 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044451 Css NA 0.04648 mg/L PBTK NA 50% Rat Human +DTXSID9044451 Css NA 0.2012 mg/L PBTK NA 95% Rat Human +DTXSID9044455 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044455 Fup 0.0949 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044455 Vd NA 2.939 L/kg 1compartment NA NA Human Human +DTXSID9044455 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9044455 TK.Half.Life NA 24.85 hours 1compartment NA NA Human Human +DTXSID9044455 Css NA 0.9618 mg/L 3compartmentss NA 50% Human Human +DTXSID9044455 Css NA 6.338 mg/L 3compartmentss NA 95% Human Human +DTXSID9044455 Css NA 0.667 mg/L PBTK NA 50% Human Human +DTXSID9044455 Css NA 4.291 mg/L PBTK NA 95% Human Human +DTXSID9044455 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044455 Fup 0.0949 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044455 Vd NA 2.208 L/kg 1compartment NA NA Rat Human +DTXSID9044455 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9044455 TK.Half.Life NA 4.498 hours 1compartment NA NA Rat Human +DTXSID9044455 Css NA 0.1251 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044455 Css NA 0.6543 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044455 Css NA 0.08584 mg/L PBTK NA 50% Rat Human +DTXSID9044455 Css NA 0.4496 mg/L PBTK NA 95% Rat Human +DTXSID9044459 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9044459 Fup 0.00183 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9044459 Vd NA 0.4916 L/kg 1compartment NA NA Human Human -DTXSID9044459 Days.Css NA 58 Days PBTK NA NA Human Human -DTXSID9044459 TK.Half.Life NA 241 hours 1compartment NA NA Human Human -DTXSID9044459 Css NA 48.59 mg/L 3compartmentss NA 50% Human Human -DTXSID9044459 Css NA 255.5 mg/L 3compartmentss NA 95% Human Human -DTXSID9044459 Css NA 29.04 mg/L PBTK NA 50% Human Human -DTXSID9044459 Css NA 150.1 mg/L PBTK NA 95% Human Human -DTXSID9044459 Clint NA 2.561 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9044459 Vd NA 0.1708 L/kg 1compartment NA NA Human Human +DTXSID9044459 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9044459 TK.Half.Life NA 16.13 hours 1compartment NA NA Human Human +DTXSID9044459 Css NA 7.974 mg/L 3compartmentss NA 50% Human Human +DTXSID9044459 Css NA 54.91 mg/L 3compartmentss NA 95% Human Human +DTXSID9044459 Css NA 4.682 mg/L PBTK NA 50% Human Human +DTXSID9044459 Css NA 31.9 mg/L PBTK NA 95% Human Human +DTXSID9044459 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9044459 Fup 0.00183 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9044459 Vd NA 0.3735 L/kg 1compartment NA NA Rat Human -DTXSID9044459 Days.Css NA 24 Days PBTK NA NA Rat Human -DTXSID9044459 TK.Half.Life NA 109.1 hours 1compartment NA NA Rat Human -DTXSID9044459 Css NA 24.58 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044459 Css NA 92.47 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044459 Css NA 13.71 mg/L PBTK NA 50% Rat Human -DTXSID9044459 Css NA 50.69 mg/L PBTK NA 95% Rat Human -DTXSID9044532 Clint NA 13.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9044459 Vd NA 0.1662 L/kg 1compartment NA NA Rat Human +DTXSID9044459 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9044459 TK.Half.Life NA 10.68 hours 1compartment NA NA Rat Human +DTXSID9044459 Css NA 0.3035 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044459 Css NA 2.485 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044459 Css NA 0.1664 mg/L PBTK NA 50% Rat Human +DTXSID9044459 Css NA 1.38 mg/L PBTK NA 95% Rat Human +DTXSID9044532 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9044532 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID9044532 Vd NA 3.146 L/kg 1compartment NA NA Human Human -DTXSID9044532 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9044532 TK.Half.Life NA 34.92 hours 1compartment NA NA Human Human -DTXSID9044532 Css NA 1.251 mg/L 3compartmentss NA 50% Human Human -DTXSID9044532 Css NA 7.415 mg/L 3compartmentss NA 95% Human Human -DTXSID9044532 Css NA 0.8916 mg/L PBTK NA 50% Human Human -DTXSID9044532 Css NA 5.067 mg/L PBTK NA 95% Human Human -DTXSID9044532 Clint NA 13.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9044532 Vd NA 1.216 L/kg 1compartment NA NA Human Human +DTXSID9044532 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044532 TK.Half.Life NA 0.8113 hours 1compartment NA NA Human Human +DTXSID9044532 Css NA 0.01425 mg/L 3compartmentss NA 50% Human Human +DTXSID9044532 Css NA 0.104 mg/L 3compartmentss NA 95% Human Human +DTXSID9044532 Css NA 0.01296 mg/L PBTK NA 50% Human Human +DTXSID9044532 Css NA 0.08593 mg/L PBTK NA 95% Human Human +DTXSID9044532 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9044532 Fup 1 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID9044532 Vd NA 2.37 L/kg 1compartment NA NA Rat Human -DTXSID9044532 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9044532 TK.Half.Life NA 4.933 hours 1compartment NA NA Rat Human -DTXSID9044532 Css NA 0.6762 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044532 Css NA 3.278 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044532 Css NA 0.4645 mg/L PBTK NA 50% Rat Human -DTXSID9044532 Css NA 2.172 mg/L PBTK NA 95% Rat Human -DTXSID9044534 Clint NA 7.283 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044534 Fup NA 0.3948 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044534 Vd NA 0.9376 L/kg 1compartment NA NA Human Human +DTXSID9044532 Vd NA 1.165 L/kg 1compartment NA NA Rat Human +DTXSID9044532 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9044532 TK.Half.Life NA 0.3693 hours 1compartment NA NA Rat Human +DTXSID9044532 Css NA 0.0006658 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044532 Css NA 0.00491 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044532 Css NA 0.0006186 mg/L PBTK NA 50% Rat Human +DTXSID9044532 Css NA 0.004094 mg/L PBTK NA 95% Rat Human +DTXSID9044534 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044534 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044534 Vd NA 0.8215 L/kg 1compartment NA NA Human Human DTXSID9044534 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044534 TK.Half.Life NA 1.773 hours 1compartment NA NA Human Human -DTXSID9044534 Css NA 0.1464 mg/L 3compartmentss NA 50% Human Human -DTXSID9044534 Css NA 0.9592 mg/L 3compartmentss NA 95% Human Human -DTXSID9044534 Css NA 0.1139 mg/L PBTK NA 50% Human Human -DTXSID9044534 Css NA 0.6465 mg/L PBTK NA 95% Human Human -DTXSID9044534 Clint NA 7.283 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044534 Fup NA 0.3948 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044534 Vd NA 0.8416 L/kg 1compartment NA NA Rat Human +DTXSID9044534 TK.Half.Life NA 1.046 hours 1compartment NA NA Human Human +DTXSID9044534 Css NA 0.06371 mg/L 3compartmentss NA 50% Human Human +DTXSID9044534 Css NA 0.4999 mg/L 3compartmentss NA 95% Human Human +DTXSID9044534 Css NA 0.0467 mg/L PBTK NA 50% Human Human +DTXSID9044534 Css NA 0.3372 mg/L PBTK NA 95% Human Human +DTXSID9044534 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044534 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044534 Vd NA 0.7359 L/kg 1compartment NA NA Rat Human DTXSID9044534 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044534 TK.Half.Life NA 0.8671 hours 1compartment NA NA Rat Human -DTXSID9044534 Css NA 0.07431 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044534 Css NA 0.3835 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044534 Css NA 0.05547 mg/L PBTK NA 50% Rat Human -DTXSID9044534 Css NA 0.2453 mg/L PBTK NA 95% Rat Human -DTXSID9044536 Clint NA 8.877 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044536 Fup NA 0.0269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044536 Vd NA 3.096 L/kg 1compartment NA NA Human Human -DTXSID9044536 Days.Css NA 36 Days PBTK NA NA Human Human -DTXSID9044536 TK.Half.Life NA 182.6 hours 1compartment NA NA Human Human -DTXSID9044536 Css NA 7.398 mg/L 3compartmentss NA 50% Human Human -DTXSID9044536 Css NA 46.52 mg/L 3compartmentss NA 95% Human Human -DTXSID9044536 Css NA 5.124 mg/L PBTK NA 50% Human Human -DTXSID9044536 Css NA 30.99 mg/L PBTK NA 95% Human Human -DTXSID9044536 Clint NA 8.877 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044536 Fup NA 0.0269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044536 Vd NA 2.319 L/kg 1compartment NA NA Rat Human -DTXSID9044536 Days.Css NA 20 Days PBTK NA NA Rat Human -DTXSID9044536 TK.Half.Life NA 24.79 hours 1compartment NA NA Rat Human -DTXSID9044536 Css NA 4.117 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044536 Css NA 20.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044536 Css NA 2.728 mg/L PBTK NA 50% Rat Human -DTXSID9044536 Css NA 13.11 mg/L PBTK NA 95% Rat Human +DTXSID9044534 TK.Half.Life NA 0.4899 hours 1compartment NA NA Rat Human +DTXSID9044534 Css NA 0.007962 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044534 Css NA 0.05001 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044534 Css NA 0.005817 mg/L PBTK NA 50% Rat Human +DTXSID9044534 Css NA 0.03254 mg/L PBTK NA 95% Rat Human +DTXSID9044536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044536 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044536 Vd NA 3.104 L/kg 1compartment NA NA Human Human +DTXSID9044536 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID9044536 TK.Half.Life NA 87.35 hours 1compartment NA NA Human Human +DTXSID9044536 Css NA 3.375 mg/L 3compartmentss NA 50% Human Human +DTXSID9044536 Css NA 21.4 mg/L 3compartmentss NA 95% Human Human +DTXSID9044536 Css NA 2.319 mg/L PBTK NA 50% Human Human +DTXSID9044536 Css NA 14.62 mg/L PBTK NA 95% Human Human +DTXSID9044536 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044536 Fup 0.0162 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044536 Vd NA 2.325 L/kg 1compartment NA NA Rat Human +DTXSID9044536 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID9044536 TK.Half.Life NA 12.02 hours 1compartment NA NA Rat Human +DTXSID9044536 Css NA 0.4337 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044536 Css NA 2.365 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044536 Css NA 0.297 mg/L PBTK NA 50% Rat Human +DTXSID9044536 Css NA 1.581 mg/L PBTK NA 95% Rat Human DTXSID9044538 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9044538 Fup 0.00145 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9044538 Vd NA 0.3284 L/kg 1compartment NA NA Human Human -DTXSID9044538 Days.Css NA 402 Days PBTK NA NA Human Human -DTXSID9044538 TK.Half.Life NA 1489 hours 1compartment NA NA Human Human -DTXSID9044538 Css NA 543.7 mg/L 3compartmentss NA 50% Human Human -DTXSID9044538 Css NA 2649 mg/L 3compartmentss NA 95% Human Human -DTXSID9044538 Css NA 316.4 mg/L PBTK NA 50% Human Human -DTXSID9044538 Css NA 1530 mg/L PBTK NA 95% Human Human +DTXSID9044538 Vd NA 0.244 L/kg 1compartment NA NA Human Human +DTXSID9044538 Days.Css NA 293 Days PBTK NA NA Human Human +DTXSID9044538 TK.Half.Life NA 1095 hours 1compartment NA NA Human Human +DTXSID9044538 Css NA 528.4 mg/L 3compartmentss NA 50% Human Human +DTXSID9044538 Css NA 2484 mg/L 3compartmentss NA 95% Human Human +DTXSID9044538 Css NA 307.6 mg/L PBTK NA 50% Human Human +DTXSID9044538 Css NA 1430 mg/L PBTK NA 95% Human Human DTXSID9044538 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9044538 Fup 0.00145 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9044538 Vd NA 0.2588 L/kg 1compartment NA NA Rat Human -DTXSID9044538 Days.Css NA 101 Days PBTK NA NA Rat Human -DTXSID9044538 TK.Half.Life NA 395.2 hours 1compartment NA NA Rat Human -DTXSID9044538 Css NA 155 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044538 Css NA 631.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044538 Css NA 84.31 mg/L PBTK NA 50% Rat Human -DTXSID9044538 Css NA 341.7 mg/L PBTK NA 95% Rat Human -DTXSID9044580 Clint NA 46.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044580 Fup NA 0.269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044580 Vd NA 0.9164 L/kg 1compartment NA NA Human Human -DTXSID9044580 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044580 TK.Half.Life NA 0.9669 hours 1compartment NA NA Human Human -DTXSID9044580 Css NA 0.03834 mg/L 3compartmentss NA 50% Human Human -DTXSID9044580 Css NA 0.2893 mg/L 3compartmentss NA 95% Human Human -DTXSID9044580 Css NA 0.02772 mg/L PBTK NA 50% Human Human -DTXSID9044580 Css NA 0.1914 mg/L PBTK NA 95% Human Human -DTXSID9044580 Clint NA 46.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044580 Fup NA 0.269 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044580 Vd NA 0.79 L/kg 1compartment NA NA Rat Human -DTXSID9044580 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044580 TK.Half.Life NA 0.4114 hours 1compartment NA NA Rat Human -DTXSID9044580 Css NA 0.02128 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044580 Css NA 0.1224 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044580 Css NA 0.01472 mg/L PBTK NA 50% Rat Human -DTXSID9044580 Css NA 0.07986 mg/L PBTK NA 95% Rat Human -DTXSID9044582 Clint NA 10.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044582 Fup NA 0.0606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044582 Vd NA 3.015 L/kg 1compartment NA NA Human Human -DTXSID9044582 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID9044582 TK.Half.Life NA 84.03 hours 1compartment NA NA Human Human -DTXSID9044582 Css NA 3.486 mg/L 3compartmentss NA 50% Human Human -DTXSID9044582 Css NA 21.06 mg/L 3compartmentss NA 95% Human Human -DTXSID9044582 Css NA 2.408 mg/L PBTK NA 50% Human Human -DTXSID9044582 Css NA 13.9 mg/L PBTK NA 95% Human Human -DTXSID9044582 Clint NA 10.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044582 Fup NA 0.0606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044582 Vd NA 2.261 L/kg 1compartment NA NA Rat Human -DTXSID9044582 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID9044582 TK.Half.Life NA 12.93 hours 1compartment NA NA Rat Human -DTXSID9044582 Css NA 1.919 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044582 Css NA 9.023 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044582 Css NA 1.268 mg/L PBTK NA 50% Rat Human -DTXSID9044582 Css NA 5.868 mg/L PBTK NA 95% Rat Human -DTXSID9044588 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044588 Fup NA 0.6593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044588 Vd NA 1.026 L/kg 1compartment NA NA Human Human -DTXSID9044588 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9044588 TK.Half.Life NA 10.51 hours 1compartment NA NA Human Human -DTXSID9044588 Css NA 1.116 mg/L 3compartmentss NA 50% Human Human -DTXSID9044588 Css NA 7.103 mg/L 3compartmentss NA 95% Human Human -DTXSID9044588 Css NA 0.9483 mg/L PBTK NA 50% Human Human -DTXSID9044588 Css NA 4.631 mg/L PBTK NA 95% Human Human -DTXSID9044588 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044588 Fup NA 0.6593 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044588 Vd NA 0.9588 L/kg 1compartment NA NA Rat Human +DTXSID9044538 Vd NA 0.2062 L/kg 1compartment NA NA Rat Human +DTXSID9044538 Days.Css NA 79 Days PBTK NA NA Rat Human +DTXSID9044538 TK.Half.Life NA 313.9 hours 1compartment NA NA Rat Human +DTXSID9044538 Css NA 34.54 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044538 Css NA 142.1 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044538 Css NA 19.4 mg/L PBTK NA 50% Rat Human +DTXSID9044538 Css NA 79.54 mg/L PBTK NA 95% Rat Human +DTXSID9044582 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044582 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044582 Vd NA 2.342 L/kg 1compartment NA NA Human Human +DTXSID9044582 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9044582 TK.Half.Life NA 36.03 hours 1compartment NA NA Human Human +DTXSID9044582 Css NA 2.222 mg/L 3compartmentss NA 50% Human Human +DTXSID9044582 Css NA 17.61 mg/L 3compartmentss NA 95% Human Human +DTXSID9044582 Css NA 1.447 mg/L PBTK NA 50% Human Human +DTXSID9044582 Css NA 10.95 mg/L PBTK NA 95% Human Human +DTXSID9044582 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044582 Fup 0.0119 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044582 Vd NA 1.742 L/kg 1compartment NA NA Rat Human +DTXSID9044582 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9044582 TK.Half.Life NA 9.73 hours 1compartment NA NA Rat Human +DTXSID9044582 Css NA 0.2893 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044582 Css NA 1.866 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044582 Css NA 0.1849 mg/L PBTK NA 50% Rat Human +DTXSID9044582 Css NA 1.156 mg/L PBTK NA 95% Rat Human +DTXSID9044584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044584 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044584 Vd NA 1.723 L/kg 1compartment NA NA Human Human +DTXSID9044584 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044584 TK.Half.Life NA 1.966 hours 1compartment NA NA Human Human +DTXSID9044584 Css NA 0.05256 mg/L 3compartmentss NA 50% Human Human +DTXSID9044584 Css NA 0.4167 mg/L 3compartmentss NA 95% Human Human +DTXSID9044584 Css NA 0.04577 mg/L PBTK NA 50% Human Human +DTXSID9044584 Css NA 0.3116 mg/L PBTK NA 95% Human Human +DTXSID9044584 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044584 Fup 0.313 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044584 Vd NA 1.729 L/kg 1compartment NA NA Rat Human +DTXSID9044584 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9044584 TK.Half.Life NA 1.068 hours 1compartment NA NA Rat Human +DTXSID9044584 Css NA 0.006504 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044584 Css NA 0.04143 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044584 Css NA 0.005694 mg/L PBTK NA 50% Rat Human +DTXSID9044584 Css NA 0.03153 mg/L PBTK NA 95% Rat Human +DTXSID9044588 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044588 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044588 Vd NA 1.089 L/kg 1compartment NA NA Human Human +DTXSID9044588 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044588 TK.Half.Life NA 1.239 hours 1compartment NA NA Human Human +DTXSID9044588 Css NA 0.05149 mg/L 3compartmentss NA 50% Human Human +DTXSID9044588 Css NA 0.3958 mg/L 3compartmentss NA 95% Human Human +DTXSID9044588 Css NA 0.03949 mg/L PBTK NA 50% Human Human +DTXSID9044588 Css NA 0.2792 mg/L PBTK NA 95% Human Human +DTXSID9044588 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044588 Fup 0.389 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044588 Vd NA 0.9412 L/kg 1compartment NA NA Rat Human DTXSID9044588 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044588 TK.Half.Life NA 3.241 hours 1compartment NA NA Rat Human -DTXSID9044588 Css NA 0.2922 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044588 Css NA 1.844 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044588 Css NA 0.2396 mg/L PBTK NA 50% Rat Human -DTXSID9044588 Css NA 1.107 mg/L PBTK NA 95% Rat Human -DTXSID9044611 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044611 Fup NA 0.2036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044611 Vd NA 0.3293 L/kg 1compartment NA NA Human Human -DTXSID9044611 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9044611 TK.Half.Life NA 10.47 hours 1compartment NA NA Human Human -DTXSID9044611 Css NA 3.944 mg/L 3compartmentss NA 50% Human Human -DTXSID9044611 Css NA 14.54 mg/L 3compartmentss NA 95% Human Human -DTXSID9044611 Css NA 2.583 mg/L PBTK NA 50% Human Human -DTXSID9044611 Css NA 8.917 mg/L PBTK NA 95% Human Human -DTXSID9044611 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044611 Fup NA 0.2036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044611 Vd NA 0.3315 L/kg 1compartment NA NA Rat Human +DTXSID9044588 TK.Half.Life NA 0.5411 hours 1compartment NA NA Rat Human +DTXSID9044588 Css NA 0.006305 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044588 Css NA 0.03916 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044588 Css NA 0.004915 mg/L PBTK NA 50% Rat Human +DTXSID9044588 Css NA 0.02692 mg/L PBTK NA 95% Rat Human +DTXSID9044611 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044611 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044611 Vd NA 0.2432 L/kg 1compartment NA NA Human Human +DTXSID9044611 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044611 TK.Half.Life NA 0.7638 hours 1compartment NA NA Human Human +DTXSID9044611 Css NA 0.1803 mg/L 3compartmentss NA 50% Human Human +DTXSID9044611 Css NA 1.375 mg/L 3compartmentss NA 95% Human Human +DTXSID9044611 Css NA 0.1117 mg/L PBTK NA 50% Human Human +DTXSID9044611 Css NA 0.8143 mg/L PBTK NA 95% Human Human +DTXSID9044611 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044611 Fup 0.161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044611 Vd NA 0.2515 L/kg 1compartment NA NA Rat Human DTXSID9044611 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044611 TK.Half.Life NA 3.59 hours 1compartment NA NA Rat Human -DTXSID9044611 Css NA 1.108 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044611 Css NA 3.336 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044611 Css NA 0.683 mg/L PBTK NA 50% Rat Human -DTXSID9044611 Css NA 1.894 mg/L PBTK NA 95% Rat Human -DTXSID9044613 Clint NA 0.8233 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044613 Fup NA 0.1643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044613 Vd NA 2.784 L/kg 1compartment NA NA Human Human -DTXSID9044613 Days.Css NA 35 Days PBTK NA NA Human Human -DTXSID9044613 TK.Half.Life NA 178.2 hours 1compartment NA NA Human Human -DTXSID9044613 Css NA 7.655 mg/L 3compartmentss NA 50% Human Human -DTXSID9044613 Css NA 26.5 mg/L 3compartmentss NA 95% Human Human -DTXSID9044613 Css NA 5.468 mg/L PBTK NA 50% Human Human -DTXSID9044613 Css NA 17.52 mg/L PBTK NA 95% Human Human -DTXSID9044613 Clint NA 0.8233 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044613 Fup NA 0.1643 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044613 Vd NA 2.102 L/kg 1compartment NA NA Rat Human -DTXSID9044613 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID9044613 TK.Half.Life NA 27.47 hours 1compartment NA NA Rat Human -DTXSID9044613 Css NA 3.197 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044613 Css NA 7.862 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044613 Css NA 2.18 mg/L PBTK NA 50% Rat Human -DTXSID9044613 Css NA 4.876 mg/L PBTK NA 95% Rat Human -DTXSID9044615 Clint NA 0.8242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044615 Fup NA 0.7976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044615 Vd NA 1.415 L/kg 1compartment NA NA Human Human -DTXSID9044615 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044615 TK.Half.Life NA 5.603 hours 1compartment NA NA Human Human -DTXSID9044615 Css NA 0.4012 mg/L 3compartmentss NA 50% Human Human -DTXSID9044615 Css NA 2.685 mg/L 3compartmentss NA 95% Human Human -DTXSID9044615 Css NA 0.3628 mg/L PBTK NA 50% Human Human -DTXSID9044615 Css NA 1.823 mg/L PBTK NA 95% Human Human -DTXSID9044615 Clint NA 0.8242 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044615 Fup NA 0.7976 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044615 Vd NA 1.277 L/kg 1compartment NA NA Rat Human +DTXSID9044611 TK.Half.Life NA 0.4671 hours 1compartment NA NA Rat Human +DTXSID9044611 Css NA 0.001825 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044611 Css NA 0.01186 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044611 Css NA 0.001067 mg/L PBTK NA 50% Rat Human +DTXSID9044611 Css NA 0.00672 mg/L PBTK NA 95% Rat Human +DTXSID9044613 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044613 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044613 Vd NA 2.277 L/kg 1compartment NA NA Human Human +DTXSID9044613 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044613 TK.Half.Life NA 8.445 hours 1compartment NA NA Human Human +DTXSID9044613 Css NA 0.411 mg/L 3compartmentss NA 50% Human Human +DTXSID9044613 Css NA 2.714 mg/L 3compartmentss NA 95% Human Human +DTXSID9044613 Css NA 0.28 mg/L PBTK NA 50% Human Human +DTXSID9044613 Css NA 1.783 mg/L PBTK NA 95% Human Human +DTXSID9044613 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044613 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044613 Vd NA 1.72 L/kg 1compartment NA NA Rat Human +DTXSID9044613 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9044613 TK.Half.Life NA 2.502 hours 1compartment NA NA Rat Human +DTXSID9044613 Css NA 0.0518 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044613 Css NA 0.2862 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044613 Css NA 0.03507 mg/L PBTK NA 50% Rat Human +DTXSID9044613 Css NA 0.1865 mg/L PBTK NA 95% Rat Human +DTXSID9044615 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044615 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044615 Vd NA 0.8947 L/kg 1compartment NA NA Human Human +DTXSID9044615 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9044615 TK.Half.Life NA 12.53 hours 1compartment NA NA Human Human +DTXSID9044615 Css NA 1.434 mg/L 3compartmentss NA 50% Human Human +DTXSID9044615 Css NA 6.919 mg/L 3compartmentss NA 95% Human Human +DTXSID9044615 Css NA 1.144 mg/L PBTK NA 50% Human Human +DTXSID9044615 Css NA 4.519 mg/L PBTK NA 95% Human Human +DTXSID9044615 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044615 Fup 0.479 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044615 Vd NA 0.8316 L/kg 1compartment NA NA Rat Human DTXSID9044615 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044615 TK.Half.Life NA 2.21 hours 1compartment NA NA Rat Human -DTXSID9044615 Css NA 0.1446 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044615 Css NA 0.9773 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044615 Css NA 0.13 mg/L PBTK NA 50% Rat Human -DTXSID9044615 Css NA 0.6037 mg/L PBTK NA 95% Rat Human -DTXSID9044661 Clint NA 14.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044661 Fup NA 0.0114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044661 Vd NA 1.817 L/kg 1compartment NA NA Human Human -DTXSID9044661 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9044661 TK.Half.Life NA 36.58 hours 1compartment NA NA Human Human -DTXSID9044661 Css NA 3.255 mg/L 3compartmentss NA 50% Human Human -DTXSID9044661 Css NA 27.55 mg/L 3compartmentss NA 95% Human Human -DTXSID9044661 Css NA 2.066 mg/L PBTK NA 50% Human Human -DTXSID9044661 Css NA 16.87 mg/L PBTK NA 95% Human Human -DTXSID9044661 Clint NA 14.81 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044661 Fup NA 0.0114 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044661 Vd NA 1.345 L/kg 1compartment NA NA Rat Human -DTXSID9044661 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9044661 TK.Half.Life NA 12.57 hours 1compartment NA NA Rat Human -DTXSID9044661 Css NA 1.835 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044661 Css NA 12.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044661 Css NA 1.086 mg/L PBTK NA 50% Rat Human -DTXSID9044661 Css NA 6.932 mg/L PBTK NA 95% Rat Human -DTXSID9044663 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044663 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044663 Vd NA 0.2337 L/kg 1compartment NA NA Human Human -DTXSID9044663 Days.Css NA 11 Days PBTK NA NA Human Human -DTXSID9044663 TK.Half.Life NA 61.34 hours 1compartment NA NA Human Human -DTXSID9044663 Css NA 45.73 mg/L 3compartmentss NA 50% Human Human -DTXSID9044663 Css NA 269.9 mg/L 3compartmentss NA 95% Human Human -DTXSID9044663 Css NA 26.9 mg/L PBTK NA 50% Human Human -DTXSID9044663 Css NA 155.7 mg/L PBTK NA 95% Human Human -DTXSID9044663 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044663 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044663 Vd NA 0.2187 L/kg 1compartment NA NA Rat Human -DTXSID9044663 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9044663 TK.Half.Life NA 19.53 hours 1compartment NA NA Rat Human -DTXSID9044663 Css NA 12.95 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044663 Css NA 64.82 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044663 Css NA 7.122 mg/L PBTK NA 50% Rat Human -DTXSID9044663 Css NA 35.14 mg/L PBTK NA 95% Rat Human -DTXSID9044667 Clint NA 118.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044667 Fup NA 0.4855 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044667 Vd NA 3.278 L/kg 1compartment NA NA Human Human -DTXSID9044667 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044667 TK.Half.Life NA 1.428 hours 1compartment NA NA Human Human -DTXSID9044667 Css NA 0.003919 mg/L 3compartmentss NA 50% Human Human -DTXSID9044667 Css NA 0.04533 mg/L 3compartmentss NA 95% Human Human -DTXSID9044667 Css NA 0.005214 mg/L PBTK NA 50% Human Human -DTXSID9044667 Css NA 0.04276 mg/L PBTK NA 95% Human Human -DTXSID9044667 Clint NA 118.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044667 Fup NA 0.4855 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044667 Vd NA 3.249 L/kg 1compartment NA NA Rat Human -DTXSID9044667 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044667 TK.Half.Life NA 0.6583 hours 1compartment NA NA Rat Human -DTXSID9044667 Css NA 0.001999 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044667 Css NA 0.01942 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044667 Css NA 0.002707 mg/L PBTK NA 50% Rat Human -DTXSID9044667 Css NA 0.01854 mg/L PBTK NA 95% Rat Human -DTXSID9044740 Clint NA 39.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044740 Fup NA 0.398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044740 Vd NA 1.245 L/kg 1compartment NA NA Human Human +DTXSID9044615 TK.Half.Life NA 3.862 hours 1compartment NA NA Rat Human +DTXSID9044615 Css NA 0.09087 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044615 Css NA 0.3927 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044615 Css NA 0.07214 mg/L PBTK NA 50% Rat Human +DTXSID9044615 Css NA 0.2468 mg/L PBTK NA 95% Rat Human +DTXSID9044619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044619 Fup 0.463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044619 Vd NA 3.488 L/kg 1compartment NA NA Human Human +DTXSID9044619 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044619 TK.Half.Life NA 2.274 hours 1compartment NA NA Human Human +DTXSID9044619 Css NA 0.01822 mg/L 3compartmentss NA 50% Human Human +DTXSID9044619 Css NA 0.2008 mg/L 3compartmentss NA 95% Human Human +DTXSID9044619 Css NA 0.02536 mg/L PBTK NA 50% Human Human +DTXSID9044619 Css NA 0.1961 mg/L PBTK NA 95% Human Human +DTXSID9044619 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044619 Fup 0.463 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044619 Vd NA 3.461 L/kg 1compartment NA NA Rat Human +DTXSID9044619 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9044619 TK.Half.Life NA 1.216 hours 1compartment NA NA Rat Human +DTXSID9044619 Css NA 0.002163 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044619 Css NA 0.02024 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044619 Css NA 0.00315 mg/L PBTK NA 50% Rat Human +DTXSID9044619 Css NA 0.01957 mg/L PBTK NA 95% Rat Human +DTXSID9044661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044661 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044661 Vd NA 5.309 L/kg 1compartment NA NA Human Human +DTXSID9044661 Days.Css NA 29 Days PBTK NA NA Human Human +DTXSID9044661 TK.Half.Life NA 158.9 hours 1compartment NA NA Human Human +DTXSID9044661 Css NA 2.872 mg/L 3compartmentss NA 50% Human Human +DTXSID9044661 Css NA 17.45 mg/L 3compartmentss NA 95% Human Human +DTXSID9044661 Css NA 2.385 mg/L PBTK NA 50% Human Human +DTXSID9044661 Css NA 14.19 mg/L PBTK NA 95% Human Human +DTXSID9044661 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044661 Fup 0.0171 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044661 Vd NA 4.063 L/kg 1compartment NA NA Rat Human +DTXSID9044661 Days.Css NA 17 Days PBTK NA NA Rat Human +DTXSID9044661 TK.Half.Life NA 21.61 hours 1compartment NA NA Rat Human +DTXSID9044661 Css NA 0.3698 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044661 Css NA 1.809 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044661 Css NA 0.3092 mg/L PBTK NA 50% Rat Human +DTXSID9044661 Css NA 1.548 mg/L PBTK NA 95% Rat Human +DTXSID9044663 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044663 Fup 0.0585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044663 Vd NA 0.2268 L/kg 1compartment NA NA Human Human +DTXSID9044663 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044663 TK.Half.Life NA 2.391 hours 1compartment NA NA Human Human +DTXSID9044663 Css NA 0.9414 mg/L 3compartmentss NA 50% Human Human +DTXSID9044663 Css NA 7.017 mg/L 3compartmentss NA 95% Human Human +DTXSID9044663 Css NA 0.5628 mg/L PBTK NA 50% Human Human +DTXSID9044663 Css NA 4.17 mg/L PBTK NA 95% Human Human +DTXSID9044663 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044663 Fup 0.0585 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044663 Vd NA 0.2275 L/kg 1compartment NA NA Rat Human +DTXSID9044663 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9044663 TK.Half.Life NA 1.49 hours 1compartment NA NA Rat Human +DTXSID9044663 Css NA 0.009648 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044663 Css NA 0.0613 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044663 Css NA 0.005423 mg/L PBTK NA 50% Rat Human +DTXSID9044663 Css NA 0.03382 mg/L PBTK NA 95% Rat Human +DTXSID9044667 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044667 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044667 Vd NA 2.485 L/kg 1compartment NA NA Human Human +DTXSID9044667 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID9044667 TK.Half.Life NA 42.16 hours 1compartment NA NA Human Human +DTXSID9044667 Css NA 1.189 mg/L 3compartmentss NA 50% Human Human +DTXSID9044667 Css NA 6.57 mg/L 3compartmentss NA 95% Human Human +DTXSID9044667 Css NA 1.357 mg/L PBTK NA 50% Human Human +DTXSID9044667 Css NA 5.123 mg/L PBTK NA 95% Human Human +DTXSID9044667 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044667 Fup 0.382 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044667 Vd NA 2.453 L/kg 1compartment NA NA Rat Human +DTXSID9044667 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9044667 TK.Half.Life NA 14.17 hours 1compartment NA NA Rat Human +DTXSID9044667 Css NA 0.07307 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044667 Css NA 0.3565 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044667 Css NA 0.08548 mg/L PBTK NA 50% Rat Human +DTXSID9044667 Css NA 0.2689 mg/L PBTK NA 95% Rat Human +DTXSID9044740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044740 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044740 Vd NA 1.976 L/kg 1compartment NA NA Human Human DTXSID9044740 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044740 TK.Half.Life NA 1.156 hours 1compartment NA NA Human Human -DTXSID9044740 Css NA 0.02988 mg/L 3compartmentss NA 50% Human Human -DTXSID9044740 Css NA 0.2404 mg/L 3compartmentss NA 95% Human Human -DTXSID9044740 Css NA 0.02344 mg/L PBTK NA 50% Human Human -DTXSID9044740 Css NA 0.1675 mg/L PBTK NA 95% Human Human -DTXSID9044740 Clint NA 39.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044740 Fup NA 0.398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044740 Vd NA 1.061 L/kg 1compartment NA NA Rat Human +DTXSID9044740 TK.Half.Life NA 2.718 hours 1compartment NA NA Human Human +DTXSID9044740 Css NA 0.07597 mg/L 3compartmentss NA 50% Human Human +DTXSID9044740 Css NA 0.5555 mg/L 3compartmentss NA 95% Human Human +DTXSID9044740 Css NA 0.05963 mg/L PBTK NA 50% Human Human +DTXSID9044740 Css NA 0.4003 mg/L PBTK NA 95% Human Human +DTXSID9044740 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044740 Fup 0.359 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044740 Vd NA 1.567 L/kg 1compartment NA NA Rat Human DTXSID9044740 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044740 TK.Half.Life NA 0.4712 hours 1compartment NA NA Rat Human -DTXSID9044740 Css NA 0.01614 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044740 Css NA 0.1004 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044740 Css NA 0.01231 mg/L PBTK NA 50% Rat Human -DTXSID9044740 Css NA 0.06745 mg/L PBTK NA 95% Rat Human -DTXSID9044742 Clint NA 41.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044742 Fup NA 0.9248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044742 Vd NA 2.193 L/kg 1compartment NA NA Human Human -DTXSID9044742 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044742 TK.Half.Life NA 1.16 hours 1compartment NA NA Human Human -DTXSID9044742 Css NA 0.01057 mg/L 3compartmentss NA 50% Human Human -DTXSID9044742 Css NA 0.08508 mg/L 3compartmentss NA 95% Human Human -DTXSID9044742 Css NA 0.0109 mg/L PBTK NA 50% Human Human -DTXSID9044742 Css NA 0.07434 mg/L PBTK NA 95% Human Human -DTXSID9044742 Clint NA 41.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044742 Fup NA 0.9248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044742 Vd NA 2.233 L/kg 1compartment NA NA Rat Human +DTXSID9044740 TK.Half.Life NA 0.9655 hours 1compartment NA NA Rat Human +DTXSID9044740 Css NA 0.009577 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044740 Css NA 0.05031 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044740 Css NA 0.007531 mg/L PBTK NA 50% Rat Human +DTXSID9044740 Css NA 0.03646 mg/L PBTK NA 95% Rat Human +DTXSID9044742 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044742 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044742 Vd NA 1.376 L/kg 1compartment NA NA Human Human +DTXSID9044742 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9044742 TK.Half.Life NA 15.06 hours 1compartment NA NA Human Human +DTXSID9044742 Css NA 0.9276 mg/L 3compartmentss NA 50% Human Human +DTXSID9044742 Css NA 7.116 mg/L 3compartmentss NA 95% Human Human +DTXSID9044742 Css NA 0.8474 mg/L PBTK NA 50% Human Human +DTXSID9044742 Css NA 4.627 mg/L PBTK NA 95% Human Human +DTXSID9044742 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044742 Fup 0.591 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044742 Vd NA 1.401 L/kg 1compartment NA NA Rat Human DTXSID9044742 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044742 TK.Half.Life NA 0.5554 hours 1compartment NA NA Rat Human -DTXSID9044742 Css NA 0.005361 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044742 Css NA 0.03766 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044742 Css NA 0.005592 mg/L PBTK NA 50% Rat Human -DTXSID9044742 Css NA 0.03334 mg/L PBTK NA 95% Rat Human -DTXSID9044744 Clint NA 1.679 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044744 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044744 Vd NA 3.437 L/kg 1compartment NA NA Human Human -DTXSID9044744 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044744 TK.Half.Life NA 6.533 hours 1compartment NA NA Human Human -DTXSID9044744 Css NA 0.1562 mg/L 3compartmentss NA 50% Human Human -DTXSID9044744 Css NA 1.426 mg/L 3compartmentss NA 95% Human Human -DTXSID9044744 Css NA 0.1912 mg/L PBTK NA 50% Human Human -DTXSID9044744 Css NA 1.151 mg/L PBTK NA 95% Human Human -DTXSID9044744 Clint NA 1.679 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044744 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044744 Vd NA 3.507 L/kg 1compartment NA NA Rat Human -DTXSID9044744 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044744 TK.Half.Life NA 3.462 hours 1compartment NA NA Rat Human -DTXSID9044744 Css NA 0.06035 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044744 Css NA 0.5044 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044744 Css NA 0.07642 mg/L PBTK NA 50% Rat Human -DTXSID9044744 Css NA 0.3606 mg/L PBTK NA 95% Rat Human -DTXSID9044748 Clint NA 5.298 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044748 Fup NA 0.189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044748 Vd NA 1.809 L/kg 1compartment NA NA Human Human +DTXSID9044742 TK.Half.Life NA 5.227 hours 1compartment NA NA Rat Human +DTXSID9044742 Css NA 0.01768 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044742 Css NA 0.1693 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044742 Css NA 0.0155 mg/L PBTK NA 50% Rat Human +DTXSID9044742 Css NA 0.1105 mg/L PBTK NA 95% Rat Human +DTXSID9044744 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044744 Fup 0.763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044744 Vd NA 3.4 L/kg 1compartment NA NA Human Human +DTXSID9044744 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9044744 TK.Half.Life NA 28.95 hours 1compartment NA NA Human Human +DTXSID9044744 Css NA 0.5698 mg/L 3compartmentss NA 50% Human Human +DTXSID9044744 Css NA 4.863 mg/L 3compartmentss NA 95% Human Human +DTXSID9044744 Css NA 0.7094 mg/L PBTK NA 50% Human Human +DTXSID9044744 Css NA 3.664 mg/L PBTK NA 95% Human Human +DTXSID9044744 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044744 Fup 0.763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044744 Vd NA 3.465 L/kg 1compartment NA NA Rat Human +DTXSID9044744 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9044744 TK.Half.Life NA 10.02 hours 1compartment NA NA Rat Human +DTXSID9044744 Css NA 0.01066 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044744 Css NA 0.1094 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044744 Css NA 0.01292 mg/L PBTK NA 50% Rat Human +DTXSID9044744 Css NA 0.0855 mg/L PBTK NA 95% Rat Human +DTXSID9044746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044746 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044746 Vd NA 2.467 L/kg 1compartment NA NA Human Human +DTXSID9044746 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044746 TK.Half.Life NA 7.264 hours 1compartment NA NA Human Human +DTXSID9044746 Css NA 0.2636 mg/L 3compartmentss NA 50% Human Human +DTXSID9044746 Css NA 1.671 mg/L 3compartmentss NA 95% Human Human +DTXSID9044746 Css NA 0.1881 mg/L PBTK NA 50% Human Human +DTXSID9044746 Css NA 1.138 mg/L PBTK NA 95% Human Human +DTXSID9044746 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044746 Fup 0.17 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044746 Vd NA 1.875 L/kg 1compartment NA NA Rat Human +DTXSID9044746 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9044746 TK.Half.Life NA 2.018 hours 1compartment NA NA Rat Human +DTXSID9044746 Css NA 0.03342 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044746 Css NA 0.1663 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044746 Css NA 0.02383 mg/L PBTK NA 50% Rat Human +DTXSID9044746 Css NA 0.114 mg/L PBTK NA 95% Rat Human +DTXSID9044748 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044748 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044748 Vd NA 1.604 L/kg 1compartment NA NA Human Human DTXSID9044748 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044748 TK.Half.Life NA 9.936 hours 1compartment NA NA Human Human -DTXSID9044748 Css NA 0.5935 mg/L 3compartmentss NA 50% Human Human -DTXSID9044748 Css NA 3.162 mg/L 3compartmentss NA 95% Human Human -DTXSID9044748 Css NA 0.4233 mg/L PBTK NA 50% Human Human -DTXSID9044748 Css NA 2.127 mg/L PBTK NA 95% Human Human -DTXSID9044748 Clint NA 5.298 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044748 Fup NA 0.189 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044748 Vd NA 1.394 L/kg 1compartment NA NA Rat Human +DTXSID9044748 TK.Half.Life NA 3.697 hours 1compartment NA NA Human Human +DTXSID9044748 Css NA 0.2149 mg/L 3compartmentss NA 50% Human Human +DTXSID9044748 Css NA 1.628 mg/L 3compartmentss NA 95% Human Human +DTXSID9044748 Css NA 0.1468 mg/L PBTK NA 50% Human Human +DTXSID9044748 Css NA 1.063 mg/L PBTK NA 95% Human Human +DTXSID9044748 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044748 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044748 Vd NA 1.232 L/kg 1compartment NA NA Rat Human DTXSID9044748 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044748 TK.Half.Life NA 3.435 hours 1compartment NA NA Rat Human -DTXSID9044748 Css NA 0.302 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044748 Css NA 1.183 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044748 Css NA 0.2064 mg/L PBTK NA 50% Rat Human -DTXSID9044748 Css NA 0.741 mg/L PBTK NA 95% Rat Human -DTXSID9044790 Clint NA 19.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044790 Fup NA 0.0497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044790 Vd NA 1.952 L/kg 1compartment NA NA Human Human -DTXSID9044790 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044790 TK.Half.Life NA 11.44 hours 1compartment NA NA Human Human -DTXSID9044790 Css NA 0.8016 mg/L 3compartmentss NA 50% Human Human -DTXSID9044790 Css NA 6.055 mg/L 3compartmentss NA 95% Human Human -DTXSID9044790 Css NA 0.526 mg/L PBTK NA 50% Human Human -DTXSID9044790 Css NA 3.788 mg/L PBTK NA 95% Human Human -DTXSID9044790 Clint NA 19.49 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044790 Fup NA 0.0497 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044790 Vd NA 1.463 L/kg 1compartment NA NA Rat Human +DTXSID9044748 TK.Half.Life NA 1.385 hours 1compartment NA NA Rat Human +DTXSID9044748 Css NA 0.0275 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044748 Css NA 0.1642 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044748 Css NA 0.01841 mg/L PBTK NA 50% Rat Human +DTXSID9044748 Css NA 0.104 mg/L PBTK NA 95% Rat Human +DTXSID9044790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044790 Fup 0.0238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044790 Vd NA 1.706 L/kg 1compartment NA NA Human Human +DTXSID9044790 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9044790 TK.Half.Life NA 14.39 hours 1compartment NA NA Human Human +DTXSID9044790 Css NA 1.24 mg/L 3compartmentss NA 50% Human Human +DTXSID9044790 Css NA 10.62 mg/L 3compartmentss NA 95% Human Human +DTXSID9044790 Css NA 0.7902 mg/L PBTK NA 50% Human Human +DTXSID9044790 Css NA 6.49 mg/L PBTK NA 95% Human Human +DTXSID9044790 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044790 Fup 0.0238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044790 Vd NA 1.268 L/kg 1compartment NA NA Rat Human DTXSID9044790 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044790 TK.Half.Life NA 3.794 hours 1compartment NA NA Rat Human -DTXSID9044790 Css NA 0.4444 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044790 Css NA 2.503 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044790 Css NA 0.274 mg/L PBTK NA 50% Rat Human -DTXSID9044790 Css NA 1.46 mg/L PBTK NA 95% Rat Human -DTXSID9044794 Clint NA 0.7919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044794 Fup NA 0.5738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044794 Vd NA 0.4851 L/kg 1compartment NA NA Human Human +DTXSID9044790 TK.Half.Life NA 5.188 hours 1compartment NA NA Rat Human +DTXSID9044790 Css NA 0.1629 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044790 Css NA 1.17 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044790 Css NA 0.1007 mg/L PBTK NA 50% Rat Human +DTXSID9044790 Css NA 0.6849 mg/L PBTK NA 95% Rat Human +DTXSID9044794 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044794 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044794 Vd NA 0.4336 L/kg 1compartment NA NA Human Human DTXSID9044794 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044794 TK.Half.Life NA 2.476 hours 1compartment NA NA Human Human -DTXSID9044794 Css NA 0.5826 mg/L 3compartmentss NA 50% Human Human -DTXSID9044794 Css NA 4.016 mg/L 3compartmentss NA 95% Human Human -DTXSID9044794 Css NA 0.4366 mg/L PBTK NA 50% Human Human -DTXSID9044794 Css NA 2.475 mg/L PBTK NA 95% Human Human -DTXSID9044794 Clint NA 0.7919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044794 Fup NA 0.5738 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044794 Vd NA 0.4917 L/kg 1compartment NA NA Rat Human +DTXSID9044794 TK.Half.Life NA 0.7839 hours 1compartment NA NA Human Human +DTXSID9044794 Css NA 0.143 mg/L 3compartmentss NA 50% Human Human +DTXSID9044794 Css NA 1.029 mg/L 3compartmentss NA 95% Human Human +DTXSID9044794 Css NA 0.1019 mg/L PBTK NA 50% Human Human +DTXSID9044794 Css NA 0.66 mg/L PBTK NA 95% Human Human +DTXSID9044794 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044794 Fup 0.478 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044794 Vd NA 0.4396 L/kg 1compartment NA NA Rat Human DTXSID9044794 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044794 TK.Half.Life NA 1.177 hours 1compartment NA NA Rat Human -DTXSID9044794 Css NA 0.22 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044794 Css NA 1.435 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044794 Css NA 0.1578 mg/L PBTK NA 50% Rat Human -DTXSID9044794 Css NA 0.8221 mg/L PBTK NA 95% Rat Human -DTXSID9044796 Clint NA 131.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044796 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044796 Vd NA 12.45 L/kg 1compartment NA NA Human Human -DTXSID9044796 Days.Css NA 8 Days PBTK NA NA Human Human -DTXSID9044796 TK.Half.Life NA 65.7 hours 1compartment NA NA Human Human -DTXSID9044796 Css NA 0.2892 mg/L 3compartmentss NA 50% Human Human -DTXSID9044796 Css NA 1.747 mg/L 3compartmentss NA 95% Human Human -DTXSID9044796 Css NA 0.4046 mg/L PBTK NA 50% Human Human -DTXSID9044796 Css NA 2.302 mg/L PBTK NA 95% Human Human -DTXSID9044796 Clint NA 131.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044796 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044796 Vd NA 9.892 L/kg 1compartment NA NA Rat Human -DTXSID9044796 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID9044796 TK.Half.Life NA 10.1 hours 1compartment NA NA Rat Human -DTXSID9044796 Css NA 0.155 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044796 Css NA 0.665 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044796 Css NA 0.2186 mg/L PBTK NA 50% Rat Human -DTXSID9044796 Css NA 0.9513 mg/L PBTK NA 95% Rat Human +DTXSID9044794 TK.Half.Life NA 0.4346 hours 1compartment NA NA Rat Human +DTXSID9044794 Css NA 0.01654 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044794 Css NA 0.09494 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044794 Css NA 0.01174 mg/L PBTK NA 50% Rat Human +DTXSID9044794 Css NA 0.05858 mg/L PBTK NA 95% Rat Human +DTXSID9044798 Clint NA 9.193 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9044798 Fup NA 0.0452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9044798 Vd NA 0.2021 L/kg 1compartment NA NA Human Human +DTXSID9044798 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044798 TK.Half.Life NA 1.938 hours 1compartment NA NA Human Human +DTXSID9044798 Css NA 1.354 mg/L 3compartmentss NA 50% Human Human +DTXSID9044798 Css NA 9.985 mg/L 3compartmentss NA 95% Human Human +DTXSID9044798 Css NA 0.7994 mg/L PBTK NA 50% Human Human +DTXSID9044798 Css NA 5.795 mg/L PBTK NA 95% Human Human +DTXSID9044798 Clint NA 9.193 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9044798 Fup NA 0.0452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9044798 Vd NA 0.2048 L/kg 1compartment NA NA Rat Human +DTXSID9044798 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9044798 TK.Half.Life NA 1.247 hours 1compartment NA NA Rat Human +DTXSID9044798 Css NA 0.04992 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044798 Css NA 0.4015 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044798 Css NA 0.02809 mg/L PBTK NA 50% Rat Human +DTXSID9044798 Css NA 0.2249 mg/L PBTK NA 95% Rat Human DTXSID9044821 Clint 161.3 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human DTXSID9044821 Fup 0.007005 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Human Human -DTXSID9044821 Vd NA 0.5271 L/kg 1compartment NA NA Human Human +DTXSID9044821 Vd NA 0.4457 L/kg 1compartment NA NA Human Human DTXSID9044821 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044821 TK.Half.Life NA 2.02 hours 1compartment NA NA Human Human -DTXSID9044821 Css NA 0.4356 mg/L 3compartmentss NA 50% Human Human -DTXSID9044821 Css NA 3.708 mg/L 3compartmentss NA 95% Human Human -DTXSID9044821 Css NA 0.2588 mg/L PBTK NA 50% Human Human -DTXSID9044821 Css NA 2.157 mg/L PBTK NA 95% Human Human +DTXSID9044821 TK.Half.Life NA 1.746 hours 1compartment NA NA Human Human +DTXSID9044821 Css NA 0.4304 mg/L 3compartmentss NA 50% Human Human +DTXSID9044821 Css NA 3.878 mg/L 3compartmentss NA 95% Human Human +DTXSID9044821 Css NA 0.2526 mg/L PBTK NA 50% Human Human +DTXSID9044821 Css NA 2.286 mg/L PBTK NA 95% Human Human DTXSID9044821 Clint 161.3 NA uL/min/million hepatocytes NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human DTXSID9044821 Fup 0.007005 NA NA https://data.europa.eu/89h/a2ff867f-db80-4acf-8e5c-e45502713bee NA Rat Human -DTXSID9044821 Vd NA 0.3989 L/kg 1compartment NA NA Rat Human +DTXSID9044821 Vd NA 0.3433 L/kg 1compartment NA NA Rat Human DTXSID9044821 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044821 TK.Half.Life NA 0.9399 hours 1compartment NA NA Rat Human -DTXSID9044821 Css NA 0.2516 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044821 Css NA 1.722 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044821 Css NA 0.1392 mg/L PBTK NA 50% Rat Human -DTXSID9044821 Css NA 0.9405 mg/L PBTK NA 95% Rat Human +DTXSID9044821 TK.Half.Life NA 0.8358 hours 1compartment NA NA Rat Human +DTXSID9044821 Css NA 0.05802 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044821 Css NA 0.4164 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044821 Css NA 0.03308 mg/L PBTK NA 50% Rat Human +DTXSID9044821 Css NA 0.2351 mg/L PBTK NA 95% Rat Human DTXSID9044823 Clint NA 0.001328 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9044823 Fup NA 0.4524 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044823 Vd NA 0.4455 L/kg 1compartment NA NA Human Human +DTXSID9044823 Vd NA 0.3767 L/kg 1compartment NA NA Human Human DTXSID9044823 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044823 TK.Half.Life NA 6.359 hours 1compartment NA NA Human Human -DTXSID9044823 Css NA 1.65 mg/L 3compartmentss NA 50% Human Human -DTXSID9044823 Css NA 7.817 mg/L 3compartmentss NA 95% Human Human -DTXSID9044823 Css NA 1.195 mg/L PBTK NA 50% Human Human -DTXSID9044823 Css NA 4.833 mg/L PBTK NA 95% Human Human +DTXSID9044823 TK.Half.Life NA 5.373 hours 1compartment NA NA Human Human +DTXSID9044823 Css NA 1.442 mg/L 3compartmentss NA 50% Human Human +DTXSID9044823 Css NA 6.769 mg/L 3compartmentss NA 95% Human Human +DTXSID9044823 Css NA 1.012 mg/L PBTK NA 50% Human Human +DTXSID9044823 Css NA 4.156 mg/L PBTK NA 95% Human Human DTXSID9044823 Clint NA 0.001328 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9044823 Fup NA 0.4524 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044823 Vd NA 0.4509 L/kg 1compartment NA NA Rat Human +DTXSID9044823 Vd NA 0.3886 L/kg 1compartment NA NA Rat Human DTXSID9044823 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044823 TK.Half.Life NA 2.195 hours 1compartment NA NA Rat Human -DTXSID9044823 Css NA 0.4494 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044823 Css NA 1.871 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044823 Css NA 0.3109 mg/L PBTK NA 50% Rat Human -DTXSID9044823 Css NA 1.091 mg/L PBTK NA 95% Rat Human +DTXSID9044823 TK.Half.Life NA 1.892 hours 1compartment NA NA Rat Human +DTXSID9044823 Css NA 0.02679 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044823 Css NA 0.1749 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044823 Css NA 0.01803 mg/L PBTK NA 50% Rat Human +DTXSID9044823 Css NA 0.1066 mg/L PBTK NA 95% Rat Human DTXSID9044825 Clint 40.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9044825 Fup 0.116 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9044825 Vd NA 2.397 L/kg 1compartment NA NA Human Human DTXSID9044825 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9044825 TK.Half.Life NA 5.686 hours 1compartment NA NA Human Human -DTXSID9044825 Css NA 0.1983 mg/L 3compartmentss NA 50% Human Human -DTXSID9044825 Css NA 1.278 mg/L 3compartmentss NA 95% Human Human -DTXSID9044825 Css NA 0.1391 mg/L PBTK NA 50% Human Human -DTXSID9044825 Css NA 0.8518 mg/L PBTK NA 95% Human Human +DTXSID9044825 Css NA 0.19 mg/L 3compartmentss NA 50% Human Human +DTXSID9044825 Css NA 1.229 mg/L 3compartmentss NA 95% Human Human +DTXSID9044825 Css NA 0.1326 mg/L PBTK NA 50% Human Human +DTXSID9044825 Css NA 0.8295 mg/L PBTK NA 95% Human Human DTXSID9044825 Clint 40.2 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9044825 Fup 0.116 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9044825 Vd NA 1.812 L/kg 1compartment NA NA Rat Human DTXSID9044825 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9044825 TK.Half.Life NA 1.648 hours 1compartment NA NA Rat Human -DTXSID9044825 Css NA 0.1098 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044825 Css NA 0.5394 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044825 Css NA 0.07376 mg/L PBTK NA 50% Rat Human -DTXSID9044825 Css NA 0.3506 mg/L PBTK NA 95% Rat Human -DTXSID9044827 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044827 Fup NA 0.9011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044827 Vd NA 1.221 L/kg 1compartment NA NA Human Human +DTXSID9044825 Css NA 0.02453 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044825 Css NA 0.128 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044825 Css NA 0.01702 mg/L PBTK NA 50% Rat Human +DTXSID9044825 Css NA 0.08771 mg/L PBTK NA 95% Rat Human +DTXSID9044827 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044827 Fup 0.792 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044827 Vd NA 1.082 L/kg 1compartment NA NA Human Human DTXSID9044827 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044827 TK.Half.Life NA 0.724 hours 1compartment NA NA Human Human -DTXSID9044827 Css NA 0.008598 mg/L 3compartmentss NA 50% Human Human -DTXSID9044827 Css NA 0.07047 mg/L 3compartmentss NA 95% Human Human -DTXSID9044827 Css NA 0.007694 mg/L PBTK NA 50% Human Human -DTXSID9044827 Css NA 0.0552 mg/L PBTK NA 95% Human Human -DTXSID9044827 Clint NA 60.44 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044827 Fup NA 0.9011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044827 Vd NA 1.157 L/kg 1compartment NA NA Rat Human +DTXSID9044827 TK.Half.Life NA 0.8228 hours 1compartment NA NA Human Human +DTXSID9044827 Css NA 0.02513 mg/L 3compartmentss NA 50% Human Human +DTXSID9044827 Css NA 0.2676 mg/L 3compartmentss NA 95% Human Human +DTXSID9044827 Css NA 0.02169 mg/L PBTK NA 50% Human Human +DTXSID9044827 Css NA 0.1937 mg/L PBTK NA 95% Human Human +DTXSID9044827 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044827 Fup 0.792 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044827 Vd NA 1.034 L/kg 1compartment NA NA Rat Human DTXSID9044827 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044827 TK.Half.Life NA 0.3096 hours 1compartment NA NA Rat Human -DTXSID9044827 Css NA 0.004412 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044827 Css NA 0.03029 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044827 Css NA 0.003929 mg/L PBTK NA 50% Rat Human -DTXSID9044827 Css NA 0.02376 mg/L PBTK NA 95% Rat Human -DTXSID9044829 Clint NA 22.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044829 Fup NA 0.0369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044829 Vd NA 2.942 L/kg 1compartment NA NA Human Human -DTXSID9044829 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9044829 TK.Half.Life NA 40.04 hours 1compartment NA NA Human Human -DTXSID9044829 Css NA 1.707 mg/L 3compartmentss NA 50% Human Human -DTXSID9044829 Css NA 11.25 mg/L 3compartmentss NA 95% Human Human -DTXSID9044829 Css NA 1.178 mg/L PBTK NA 50% Human Human -DTXSID9044829 Css NA 7.354 mg/L PBTK NA 95% Human Human -DTXSID9044829 Clint NA 22.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044829 Fup NA 0.0369 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044829 Vd NA 2.204 L/kg 1compartment NA NA Rat Human -DTXSID9044829 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9044829 TK.Half.Life NA 6.935 hours 1compartment NA NA Rat Human -DTXSID9044829 Css NA 0.9609 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044829 Css NA 5.042 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044829 Css NA 0.6287 mg/L PBTK NA 50% Rat Human -DTXSID9044829 Css NA 3.209 mg/L PBTK NA 95% Rat Human -DTXSID9044875 Clint NA 0.1826 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044875 Fup NA 0.8191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044875 Vd NA 2.072 L/kg 1compartment NA NA Human Human -DTXSID9044875 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9044875 TK.Half.Life NA 12.62 hours 1compartment NA NA Human Human -DTXSID9044875 Css NA 0.5842 mg/L 3compartmentss NA 50% Human Human -DTXSID9044875 Css NA 4.056 mg/L 3compartmentss NA 95% Human Human -DTXSID9044875 Css NA 0.6087 mg/L PBTK NA 50% Human Human -DTXSID9044875 Css NA 2.822 mg/L PBTK NA 95% Human Human -DTXSID9044875 Clint NA 0.1826 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044875 Fup NA 0.8191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044875 Vd NA 2.092 L/kg 1compartment NA NA Rat Human +DTXSID9044827 TK.Half.Life NA 0.3804 hours 1compartment NA NA Rat Human +DTXSID9044827 Css NA 0.002988 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044827 Css NA 0.02718 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044827 Css NA 0.002656 mg/L PBTK NA 50% Rat Human +DTXSID9044827 Css NA 0.01939 mg/L PBTK NA 95% Rat Human +DTXSID9044829 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044829 Fup 0.00839 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044829 Vd NA 3.622 L/kg 1compartment NA NA Human Human +DTXSID9044829 Days.Css NA 18 Days PBTK NA NA Human Human +DTXSID9044829 TK.Half.Life NA 110.1 hours 1compartment NA NA Human Human +DTXSID9044829 Css NA 3.319 mg/L 3compartmentss NA 50% Human Human +DTXSID9044829 Css NA 20.12 mg/L 3compartmentss NA 95% Human Human +DTXSID9044829 Css NA 2.4 mg/L PBTK NA 50% Human Human +DTXSID9044829 Css NA 14.4 mg/L PBTK NA 95% Human Human +DTXSID9044829 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044829 Fup 0.00839 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044829 Vd NA 2.729 L/kg 1compartment NA NA Rat Human +DTXSID9044829 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID9044829 TK.Half.Life NA 15.14 hours 1compartment NA NA Rat Human +DTXSID9044829 Css NA 0.4354 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044829 Css NA 2.135 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044829 Css NA 0.3118 mg/L PBTK NA 50% Rat Human +DTXSID9044829 Css NA 1.552 mg/L PBTK NA 95% Rat Human +DTXSID9044871 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044871 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044871 Vd NA 1.532 L/kg 1compartment NA NA Human Human +DTXSID9044871 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9044871 TK.Half.Life NA 3.629 hours 1compartment NA NA Human Human +DTXSID9044871 Css NA 0.2298 mg/L 3compartmentss NA 50% Human Human +DTXSID9044871 Css NA 1.822 mg/L 3compartmentss NA 95% Human Human +DTXSID9044871 Css NA 0.1584 mg/L PBTK NA 50% Human Human +DTXSID9044871 Css NA 1.174 mg/L PBTK NA 95% Human Human +DTXSID9044871 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044871 Fup 0.125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044871 Vd NA 1.228 L/kg 1compartment NA NA Rat Human +DTXSID9044871 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9044871 TK.Half.Life NA 1.498 hours 1compartment NA NA Rat Human +DTXSID9044871 Css NA 0.02941 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044871 Css NA 0.1752 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044871 Css NA 0.01985 mg/L PBTK NA 50% Rat Human +DTXSID9044871 Css NA 0.1102 mg/L PBTK NA 95% Rat Human +DTXSID9044875 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044875 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044875 Vd NA 1.57 L/kg 1compartment NA NA Human Human +DTXSID9044875 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9044875 TK.Half.Life NA 21.75 hours 1compartment NA NA Human Human +DTXSID9044875 Css NA 1.069 mg/L 3compartmentss NA 50% Human Human +DTXSID9044875 Css NA 5.833 mg/L 3compartmentss NA 95% Human Human +DTXSID9044875 Css NA 0.9918 mg/L PBTK NA 50% Human Human +DTXSID9044875 Css NA 4.07 mg/L PBTK NA 95% Human Human +DTXSID9044875 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044875 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044875 Vd NA 1.573 L/kg 1compartment NA NA Rat Human DTXSID9044875 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044875 TK.Half.Life NA 4.916 hours 1compartment NA NA Rat Human -DTXSID9044875 Css NA 0.1678 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044875 Css NA 1.212 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044875 Css NA 0.1736 mg/L PBTK NA 50% Rat Human -DTXSID9044875 Css NA 0.7861 mg/L PBTK NA 95% Rat Human -DTXSID9044877 Clint NA 14.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044877 Fup NA 0.7051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044877 Vd NA 0.8897 L/kg 1compartment NA NA Human Human +DTXSID9044875 TK.Half.Life NA 7.428 hours 1compartment NA NA Rat Human +DTXSID9044875 Css NA 0.02003 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044875 Css NA 0.1434 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044875 Css NA 0.0179 mg/L PBTK NA 50% Rat Human +DTXSID9044875 Css NA 0.1046 mg/L PBTK NA 95% Rat Human +DTXSID9044877 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044877 Fup 0.519 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044877 Vd NA 0.7439 L/kg 1compartment NA NA Human Human DTXSID9044877 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044877 TK.Half.Life NA 0.815 hours 1compartment NA NA Human Human -DTXSID9044877 Css NA 0.04504 mg/L 3compartmentss NA 50% Human Human -DTXSID9044877 Css NA 0.4227 mg/L 3compartmentss NA 95% Human Human -DTXSID9044877 Css NA 0.0371 mg/L PBTK NA 50% Human Human -DTXSID9044877 Css NA 0.2981 mg/L PBTK NA 95% Human Human -DTXSID9044877 Clint NA 14.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044877 Fup NA 0.7051 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044877 Vd NA 0.8736 L/kg 1compartment NA NA Rat Human +DTXSID9044877 TK.Half.Life NA 0.7247 hours 1compartment NA NA Human Human +DTXSID9044877 Css NA 0.03748 mg/L 3compartmentss NA 50% Human Human +DTXSID9044877 Css NA 0.3415 mg/L 3compartmentss NA 95% Human Human +DTXSID9044877 Css NA 0.02928 mg/L PBTK NA 50% Human Human +DTXSID9044877 Css NA 0.2387 mg/L PBTK NA 95% Human Human +DTXSID9044877 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044877 Fup 0.519 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044877 Vd NA 0.7279 L/kg 1compartment NA NA Rat Human DTXSID9044877 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044877 TK.Half.Life NA 0.4032 hours 1compartment NA NA Rat Human -DTXSID9044877 Css NA 0.02189 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044877 Css NA 0.1998 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044877 Css NA 0.0179 mg/L PBTK NA 50% Rat Human -DTXSID9044877 Css NA 0.1287 mg/L PBTK NA 95% Rat Human -DTXSID9044879 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044879 Fup NA 0.5395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044879 Vd NA 1.504 L/kg 1compartment NA NA Human Human +DTXSID9044877 TK.Half.Life NA 0.356 hours 1compartment NA NA Rat Human +DTXSID9044877 Css NA 0.00451 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044877 Css NA 0.03493 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044877 Css NA 0.003554 mg/L PBTK NA 50% Rat Human +DTXSID9044877 Css NA 0.02359 mg/L PBTK NA 95% Rat Human +DTXSID9044879 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044879 Fup 0.685 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044879 Vd NA 1.862 L/kg 1compartment NA NA Human Human DTXSID9044879 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9044879 TK.Half.Life NA 18.27 hours 1compartment NA NA Human Human -DTXSID9044879 Css NA 1.183 mg/L 3compartmentss NA 50% Human Human -DTXSID9044879 Css NA 7.655 mg/L 3compartmentss NA 95% Human Human -DTXSID9044879 Css NA 1.065 mg/L PBTK NA 50% Human Human -DTXSID9044879 Css NA 5.163 mg/L PBTK NA 95% Human Human -DTXSID9044879 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044879 Fup NA 0.5395 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044879 Vd NA 1.5 L/kg 1compartment NA NA Rat Human +DTXSID9044879 TK.Half.Life NA 18 hours 1compartment NA NA Human Human +DTXSID9044879 Css NA 0.7996 mg/L 3compartmentss NA 50% Human Human +DTXSID9044879 Css NA 5.899 mg/L 3compartmentss NA 95% Human Human +DTXSID9044879 Css NA 0.7851 mg/L PBTK NA 50% Human Human +DTXSID9044879 Css NA 4.063 mg/L PBTK NA 95% Human Human +DTXSID9044879 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044879 Fup 0.685 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044879 Vd NA 1.857 L/kg 1compartment NA NA Rat Human DTXSID9044879 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044879 TK.Half.Life NA 6.15 hours 1compartment NA NA Rat Human -DTXSID9044879 Css NA 0.3136 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044879 Css NA 1.913 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044879 Css NA 0.2736 mg/L PBTK NA 50% Rat Human -DTXSID9044879 Css NA 1.18 mg/L PBTK NA 95% Rat Human -DTXSID9044900 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044900 Fup NA 0.4097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044900 Vd NA 1.111 L/kg 1compartment NA NA Human Human -DTXSID9044900 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9044900 TK.Half.Life NA 19.24 hours 1compartment NA NA Human Human -DTXSID9044900 Css NA 1.828 mg/L 3compartmentss NA 50% Human Human -DTXSID9044900 Css NA 8.147 mg/L 3compartmentss NA 95% Human Human -DTXSID9044900 Css NA 1.452 mg/L PBTK NA 50% Human Human -DTXSID9044900 Css NA 5.335 mg/L PBTK NA 95% Human Human -DTXSID9044900 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044900 Fup NA 0.4097 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044900 Vd NA 0.9686 L/kg 1compartment NA NA Rat Human -DTXSID9044900 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044900 TK.Half.Life NA 5.332 hours 1compartment NA NA Rat Human -DTXSID9044900 Css NA 0.4921 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044900 Css NA 1.836 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044900 Css NA 0.375 mg/L PBTK NA 50% Rat Human -DTXSID9044900 Css NA 1.127 mg/L PBTK NA 95% Rat Human -DTXSID9044902 Clint NA 0.5553 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044902 Fup NA 0.1003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044902 Vd NA 0.4972 L/kg 1compartment NA NA Human Human -DTXSID9044902 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9044902 TK.Half.Life NA 16.84 hours 1compartment NA NA Human Human -DTXSID9044902 Css NA 4.908 mg/L 3compartmentss NA 50% Human Human -DTXSID9044902 Css NA 26.06 mg/L 3compartmentss NA 95% Human Human -DTXSID9044902 Css NA 3.218 mg/L PBTK NA 50% Human Human -DTXSID9044902 Css NA 15.42 mg/L PBTK NA 95% Human Human -DTXSID9044902 Clint NA 0.5553 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044902 Fup NA 0.1003 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044902 Vd NA 0.4466 L/kg 1compartment NA NA Rat Human -DTXSID9044902 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044902 TK.Half.Life NA 6.769 hours 1compartment NA NA Rat Human -DTXSID9044902 Css NA 1.888 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044902 Css NA 8.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044902 Css NA 1.158 mg/L PBTK NA 50% Rat Human -DTXSID9044902 Css NA 4.527 mg/L PBTK NA 95% Rat Human -DTXSID9044904 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044904 Fup NA 0.2001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044904 Vd NA 0.3026 L/kg 1compartment NA NA Human Human -DTXSID9044904 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9044904 TK.Half.Life NA 9.783 hours 1compartment NA NA Human Human -DTXSID9044904 Css NA 4.093 mg/L 3compartmentss NA 50% Human Human -DTXSID9044904 Css NA 14.76 mg/L 3compartmentss NA 95% Human Human -DTXSID9044904 Css NA 2.634 mg/L PBTK NA 50% Human Human -DTXSID9044904 Css NA 8.891 mg/L PBTK NA 95% Human Human -DTXSID9044904 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044904 Fup NA 0.2001 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044904 Vd NA 0.319 L/kg 1compartment NA NA Rat Human -DTXSID9044904 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044904 TK.Half.Life NA 3.515 hours 1compartment NA NA Rat Human -DTXSID9044904 Css NA 1.139 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044904 Css NA 3.315 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044904 Css NA 0.6903 mg/L PBTK NA 50% Rat Human -DTXSID9044904 Css NA 1.871 mg/L PBTK NA 95% Rat Human -DTXSID9044908 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044908 Fup NA 0.6603 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044908 Vd NA 1.555 L/kg 1compartment NA NA Human Human +DTXSID9044879 TK.Half.Life NA 6.012 hours 1compartment NA NA Rat Human +DTXSID9044879 Css NA 0.02028 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044879 Css NA 0.1873 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044879 Css NA 0.01959 mg/L PBTK NA 50% Rat Human +DTXSID9044879 Css NA 0.1295 mg/L PBTK NA 95% Rat Human +DTXSID9044908 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044908 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9044908 Vd NA 1.452 L/kg 1compartment NA NA Human Human DTXSID9044908 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9044908 TK.Half.Life NA 18.31 hours 1compartment NA NA Human Human -DTXSID9044908 Css NA 1.178 mg/L 3compartmentss NA 50% Human Human -DTXSID9044908 Css NA 7.209 mg/L 3compartmentss NA 95% Human Human -DTXSID9044908 Css NA 1.048 mg/L PBTK NA 50% Human Human -DTXSID9044908 Css NA 4.762 mg/L PBTK NA 95% Human Human -DTXSID9044908 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044908 Fup NA 0.6603 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044908 Vd NA 1.343 L/kg 1compartment NA NA Rat Human +DTXSID9044908 TK.Half.Life NA 18.23 hours 1compartment NA NA Human Human +DTXSID9044908 Css NA 1.233 mg/L 3compartmentss NA 50% Human Human +DTXSID9044908 Css NA 8.116 mg/L 3compartmentss NA 95% Human Human +DTXSID9044908 Css NA 1.07 mg/L PBTK NA 50% Human Human +DTXSID9044908 Css NA 5.36 mg/L PBTK NA 95% Human Human +DTXSID9044908 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044908 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9044908 Vd NA 1.258 L/kg 1compartment NA NA Rat Human DTXSID9044908 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044908 TK.Half.Life NA 4.699 hours 1compartment NA NA Rat Human -DTXSID9044908 Css NA 0.3108 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044908 Css NA 1.858 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044908 Css NA 0.2685 mg/L PBTK NA 50% Rat Human -DTXSID9044908 Css NA 1.145 mg/L PBTK NA 95% Rat Human +DTXSID9044908 TK.Half.Life NA 4.78 hours 1compartment NA NA Rat Human +DTXSID9044908 Css NA 0.07608 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044908 Css NA 0.4826 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044908 Css NA 0.06631 mg/L PBTK NA 50% Rat Human +DTXSID9044908 Css NA 0.3024 mg/L PBTK NA 95% Rat Human DTXSID9044950 Clint 28.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9044950 Fup 1.93e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9044950 Vd NA 0.1593 L/kg 1compartment NA NA Human Human DTXSID9044950 Days.Css NA 51 Days PBTK NA NA Human Human DTXSID9044950 TK.Half.Life NA 214.7 hours 1compartment NA NA Human Human -DTXSID9044950 Css NA 97.34 mg/L 3compartmentss NA 50% Human Human -DTXSID9044950 Css NA 583.3 mg/L 3compartmentss NA 95% Human Human -DTXSID9044950 Css NA 56.52 mg/L PBTK NA 50% Human Human -DTXSID9044950 Css NA 339.6 mg/L PBTK NA 95% Human Human +DTXSID9044950 Css NA 83.59 mg/L 3compartmentss NA 50% Human Human +DTXSID9044950 Css NA 556.2 mg/L 3compartmentss NA 95% Human Human +DTXSID9044950 Css NA 48.83 mg/L PBTK NA 50% Human Human +DTXSID9044950 Css NA 320 mg/L PBTK NA 95% Human Human DTXSID9044950 Clint 28.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9044950 Fup 1.93e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9044950 Vd NA 0.1579 L/kg 1compartment NA NA Rat Human DTXSID9044950 Days.Css NA 33 Days PBTK NA NA Rat Human DTXSID9044950 TK.Half.Life NA 146.2 hours 1compartment NA NA Rat Human -DTXSID9044950 Css NA 68.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044950 Css NA 214.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044950 Css NA 37.04 mg/L PBTK NA 50% Rat Human -DTXSID9044950 Css NA 115.9 mg/L PBTK NA 95% Rat Human -DTXSID9044958 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044958 Fup NA 0.729 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9044958 Vd NA 0.8833 L/kg 1compartment NA NA Human Human -DTXSID9044958 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9044958 TK.Half.Life NA 7.949 hours 1compartment NA NA Human Human -DTXSID9044958 Css NA 1.021 mg/L 3compartmentss NA 50% Human Human -DTXSID9044958 Css NA 7.03 mg/L 3compartmentss NA 95% Human Human -DTXSID9044958 Css NA 0.8657 mg/L PBTK NA 50% Human Human -DTXSID9044958 Css NA 4.507 mg/L PBTK NA 95% Human Human -DTXSID9044958 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044958 Fup NA 0.729 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9044958 Vd NA 0.8716 L/kg 1compartment NA NA Rat Human -DTXSID9044958 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9044958 TK.Half.Life NA 2.646 hours 1compartment NA NA Rat Human -DTXSID9044958 Css NA 0.2636 mg/L 3compartmentss NA 50% Rat Human -DTXSID9044958 Css NA 1.727 mg/L 3compartmentss NA 95% Rat Human -DTXSID9044958 Css NA 0.2163 mg/L PBTK NA 50% Rat Human -DTXSID9044958 Css NA 1.034 mg/L PBTK NA 95% Rat Human -DTXSID9045003 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045003 Fup NA 0.9016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045003 Vd NA 2.103 L/kg 1compartment NA NA Human Human -DTXSID9045003 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9045003 TK.Half.Life NA 22.33 hours 1compartment NA NA Human Human -DTXSID9045003 Css NA 0.9617 mg/L 3compartmentss NA 50% Human Human -DTXSID9045003 Css NA 3.813 mg/L 3compartmentss NA 95% Human Human -DTXSID9045003 Css NA 0.9286 mg/L PBTK NA 50% Human Human -DTXSID9045003 Css NA 2.858 mg/L PBTK NA 95% Human Human -DTXSID9045003 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045003 Fup NA 0.9016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045003 Vd NA 1.77 L/kg 1compartment NA NA Rat Human +DTXSID9044950 Css NA 3.52 mg/L 3compartmentss NA 50% Rat Human +DTXSID9044950 Css NA 27.48 mg/L 3compartmentss NA 95% Rat Human +DTXSID9044950 Css NA 1.921 mg/L PBTK NA 50% Rat Human +DTXSID9044950 Css NA 15.25 mg/L PBTK NA 95% Rat Human +DTXSID9045003 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045003 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045003 Vd NA 0.4411 L/kg 1compartment NA NA Human Human +DTXSID9045003 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045003 TK.Half.Life NA 1.025 hours 1compartment NA NA Human Human +DTXSID9045003 Css NA 0.1991 mg/L 3compartmentss NA 50% Human Human +DTXSID9045003 Css NA 1.25 mg/L 3compartmentss NA 95% Human Human +DTXSID9045003 Css NA 0.1386 mg/L PBTK NA 50% Human Human +DTXSID9045003 Css NA 0.8065 mg/L PBTK NA 95% Human Human +DTXSID9045003 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045003 Fup 0.341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045003 Vd NA 0.4546 L/kg 1compartment NA NA Rat Human DTXSID9045003 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045003 TK.Half.Life NA 4.824 hours 1compartment NA NA Rat Human -DTXSID9045003 Css NA 0.2513 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045003 Css NA 0.9254 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045003 Css NA 0.2384 mg/L PBTK NA 50% Rat Human -DTXSID9045003 Css NA 0.6406 mg/L PBTK NA 95% Rat Human -DTXSID9045007 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045007 Fup NA 0.1473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045007 Vd NA 0.2931 L/kg 1compartment NA NA Human Human -DTXSID9045007 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9045007 TK.Half.Life NA 12.87 hours 1compartment NA NA Human Human -DTXSID9045007 Css NA 6.396 mg/L 3compartmentss NA 50% Human Human -DTXSID9045007 Css NA 27.81 mg/L 3compartmentss NA 95% Human Human -DTXSID9045007 Css NA 4.036 mg/L PBTK NA 50% Human Human -DTXSID9045007 Css NA 16.57 mg/L PBTK NA 95% Human Human -DTXSID9045007 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045007 Fup NA 0.1473 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045007 Vd NA 0.2919 L/kg 1compartment NA NA Rat Human -DTXSID9045007 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045007 TK.Half.Life NA 4.368 hours 1compartment NA NA Rat Human -DTXSID9045007 Css NA 1.806 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045007 Css NA 6.693 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045007 Css NA 1.066 mg/L PBTK NA 50% Rat Human -DTXSID9045007 Css NA 3.711 mg/L PBTK NA 95% Rat Human -DTXSID9045132 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045132 Fup NA 0.0611 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045132 Vd NA 1.839 L/kg 1compartment NA NA Human Human -DTXSID9045132 Days.Css NA 77 Days PBTK NA NA Human Human -DTXSID9045132 TK.Half.Life NA 335 hours 1compartment NA NA Human Human -DTXSID9045132 Css NA 26.82 mg/L 3compartmentss NA 50% Human Human -DTXSID9045132 Css NA 102.8 mg/L 3compartmentss NA 95% Human Human -DTXSID9045132 Css NA 17.56 mg/L PBTK NA 50% Human Human -DTXSID9045132 Css NA 62.45 mg/L PBTK NA 95% Human Human -DTXSID9045132 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045132 Fup NA 0.0611 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045132 Vd NA 1.378 L/kg 1compartment NA NA Rat Human -DTXSID9045132 Days.Css NA 17 Days PBTK NA NA Rat Human -DTXSID9045132 TK.Half.Life NA 58.3 hours 1compartment NA NA Rat Human -DTXSID9045132 Css NA 7.415 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045132 Css NA 23.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045132 Css NA 4.584 mg/L PBTK NA 50% Rat Human -DTXSID9045132 Css NA 13.54 mg/L PBTK NA 95% Rat Human -DTXSID9045136 Clint NA 14.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045136 Fup NA 0.0537 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045136 Vd NA 1.712 L/kg 1compartment NA NA Human Human +DTXSID9045003 TK.Half.Life NA 0.596 hours 1compartment NA NA Rat Human +DTXSID9045003 Css NA 0.02376 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045003 Css NA 0.11 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045003 Css NA 0.01639 mg/L PBTK NA 50% Rat Human +DTXSID9045003 Css NA 0.06868 mg/L PBTK NA 95% Rat Human +DTXSID9045132 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045132 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045132 Vd NA 0.513 L/kg 1compartment NA NA Human Human +DTXSID9045132 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045132 TK.Half.Life NA 3.194 hours 1compartment NA NA Human Human +DTXSID9045132 Css NA 0.8933 mg/L 3compartmentss NA 50% Human Human +DTXSID9045132 Css NA 6.108 mg/L 3compartmentss NA 95% Human Human +DTXSID9045132 Css NA 0.5637 mg/L PBTK NA 50% Human Human +DTXSID9045132 Css NA 3.651 mg/L PBTK NA 95% Human Human +DTXSID9045132 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045132 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045132 Vd NA 0.4318 L/kg 1compartment NA NA Rat Human +DTXSID9045132 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045132 TK.Half.Life NA 1.611 hours 1compartment NA NA Rat Human +DTXSID9045132 Css NA 0.1081 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045132 Css NA 0.5598 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045132 Css NA 0.066 mg/L PBTK NA 50% Rat Human +DTXSID9045132 Css NA 0.3255 mg/L PBTK NA 95% Rat Human +DTXSID9045136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045136 Fup 0.226 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045136 Vd NA 2.274 L/kg 1compartment NA NA Human Human DTXSID9045136 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045136 TK.Half.Life NA 10.99 hours 1compartment NA NA Human Human -DTXSID9045136 Css NA 0.9062 mg/L 3compartmentss NA 50% Human Human -DTXSID9045136 Css NA 6.581 mg/L 3compartmentss NA 95% Human Human -DTXSID9045136 Css NA 0.5887 mg/L PBTK NA 50% Human Human -DTXSID9045136 Css NA 3.997 mg/L PBTK NA 95% Human Human -DTXSID9045136 Clint NA 14.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045136 Fup NA 0.0537 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045136 Vd NA 1.294 L/kg 1compartment NA NA Rat Human +DTXSID9045136 TK.Half.Life NA 4.69 hours 1compartment NA NA Human Human +DTXSID9045136 Css NA 0.1556 mg/L 3compartmentss NA 50% Human Human +DTXSID9045136 Css NA 1.051 mg/L 3compartmentss NA 95% Human Human +DTXSID9045136 Css NA 0.1146 mg/L PBTK NA 50% Human Human +DTXSID9045136 Css NA 0.7321 mg/L PBTK NA 95% Human Human +DTXSID9045136 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045136 Fup 0.226 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045136 Vd NA 1.766 L/kg 1compartment NA NA Rat Human DTXSID9045136 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045136 TK.Half.Life NA 4.023 hours 1compartment NA NA Rat Human -DTXSID9045136 Css NA 0.5011 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045136 Css NA 2.802 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045136 Css NA 0.3077 mg/L PBTK NA 50% Rat Human -DTXSID9045136 Css NA 1.655 mg/L PBTK NA 95% Rat Human -DTXSID9045138 Clint NA 29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045138 Fup NA 0.4851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045138 Vd NA 2.33 L/kg 1compartment NA NA Human Human +DTXSID9045136 TK.Half.Life NA 1.503 hours 1compartment NA NA Rat Human +DTXSID9045136 Css NA 0.01955 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045136 Css NA 0.0974 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045136 Css NA 0.01447 mg/L PBTK NA 50% Rat Human +DTXSID9045136 Css NA 0.06921 mg/L PBTK NA 95% Rat Human +DTXSID9045138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045138 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045138 Vd NA 2.287 L/kg 1compartment NA NA Human Human DTXSID9045138 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045138 TK.Half.Life NA 2.104 hours 1compartment NA NA Human Human -DTXSID9045138 Css NA 0.03513 mg/L 3compartmentss NA 50% Human Human -DTXSID9045138 Css NA 0.2825 mg/L 3compartmentss NA 95% Human Human -DTXSID9045138 Css NA 0.03163 mg/L PBTK NA 50% Human Human -DTXSID9045138 Css NA 0.2184 mg/L PBTK NA 95% Human Human -DTXSID9045138 Clint NA 29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045138 Fup NA 0.4851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045138 Vd NA 2.072 L/kg 1compartment NA NA Rat Human +DTXSID9045138 TK.Half.Life NA 2.35 hours 1compartment NA NA Human Human +DTXSID9045138 Css NA 0.04415 mg/L 3compartmentss NA 50% Human Human +DTXSID9045138 Css NA 0.3605 mg/L 3compartmentss NA 95% Human Human +DTXSID9045138 Css NA 0.03966 mg/L PBTK NA 50% Human Human +DTXSID9045138 Css NA 0.2831 mg/L PBTK NA 95% Human Human +DTXSID9045138 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045138 Fup 0.467 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045138 Vd NA 2.032 L/kg 1compartment NA NA Rat Human DTXSID9045138 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045138 TK.Half.Life NA 0.8725 hours 1compartment NA NA Rat Human -DTXSID9045138 Css NA 0.01823 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045138 Css NA 0.1251 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045138 Css NA 0.01624 mg/L PBTK NA 50% Rat Human -DTXSID9045138 Css NA 0.09321 mg/L PBTK NA 95% Rat Human -DTXSID9045180 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045180 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045180 Vd NA 1.547 L/kg 1compartment NA NA Human Human -DTXSID9045180 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045180 TK.Half.Life NA 10.01 hours 1compartment NA NA Human Human -DTXSID9045180 Css NA 0.7164 mg/L 3compartmentss NA 50% Human Human -DTXSID9045180 Css NA 5.301 mg/L 3compartmentss NA 95% Human Human -DTXSID9045180 Css NA 0.698 mg/L PBTK NA 50% Human Human -DTXSID9045180 Css NA 3.627 mg/L PBTK NA 95% Human Human -DTXSID9045180 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045180 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045180 Vd NA 1.6 L/kg 1compartment NA NA Rat Human +DTXSID9045138 TK.Half.Life NA 0.9905 hours 1compartment NA NA Rat Human +DTXSID9045138 Css NA 0.005378 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045138 Css NA 0.03544 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045138 Css NA 0.004963 mg/L PBTK NA 50% Rat Human +DTXSID9045138 Css NA 0.02725 mg/L PBTK NA 95% Rat Human +DTXSID9045180 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045180 Fup 0.766 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045180 Vd NA 1.286 L/kg 1compartment NA NA Human Human +DTXSID9045180 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9045180 TK.Half.Life NA 10.86 hours 1compartment NA NA Human Human +DTXSID9045180 Css NA 0.8786 mg/L 3compartmentss NA 50% Human Human +DTXSID9045180 Css NA 6.167 mg/L 3compartmentss NA 95% Human Human +DTXSID9045180 Css NA 0.8117 mg/L PBTK NA 50% Human Human +DTXSID9045180 Css NA 4.137 mg/L PBTK NA 95% Human Human +DTXSID9045180 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045180 Fup 0.766 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045180 Vd NA 1.331 L/kg 1compartment NA NA Rat Human DTXSID9045180 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045180 TK.Half.Life NA 3.527 hours 1compartment NA NA Rat Human -DTXSID9045180 Css NA 0.1766 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045180 Css NA 1.263 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045180 Css NA 0.1718 mg/L PBTK NA 50% Rat Human -DTXSID9045180 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID9045182 Clint NA 32.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045182 Fup NA 0.1418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045182 Vd NA 2.742 L/kg 1compartment NA NA Human Human -DTXSID9045182 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045182 TK.Half.Life NA 6.442 hours 1compartment NA NA Human Human -DTXSID9045182 Css NA 0.2094 mg/L 3compartmentss NA 50% Human Human -DTXSID9045182 Css NA 1.466 mg/L 3compartmentss NA 95% Human Human -DTXSID9045182 Css NA 0.1552 mg/L PBTK NA 50% Human Human -DTXSID9045182 Css NA 1.016 mg/L PBTK NA 95% Human Human -DTXSID9045182 Clint NA 32.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045182 Fup NA 0.1418 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045182 Vd NA 2.2 L/kg 1compartment NA NA Rat Human +DTXSID9045180 TK.Half.Life NA 3.832 hours 1compartment NA NA Rat Human +DTXSID9045180 Css NA 0.05158 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045180 Css NA 0.3592 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045180 Css NA 0.04805 mg/L PBTK NA 50% Rat Human +DTXSID9045180 Css NA 0.2292 mg/L PBTK NA 95% Rat Human +DTXSID9045182 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045182 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045182 Vd NA 2.508 L/kg 1compartment NA NA Human Human +DTXSID9045182 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9045182 TK.Half.Life NA 16.43 hours 1compartment NA NA Human Human +DTXSID9045182 Css NA 0.7233 mg/L 3compartmentss NA 50% Human Human +DTXSID9045182 Css NA 4.409 mg/L 3compartmentss NA 95% Human Human +DTXSID9045182 Css NA 0.5452 mg/L PBTK NA 50% Human Human +DTXSID9045182 Css NA 3.082 mg/L PBTK NA 95% Human Human +DTXSID9045182 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045182 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045182 Vd NA 2.059 L/kg 1compartment NA NA Rat Human DTXSID9045182 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045182 TK.Half.Life NA 1.99 hours 1compartment NA NA Rat Human -DTXSID9045182 Css NA 0.1152 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045182 Css NA 0.6461 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045182 Css NA 0.08272 mg/L PBTK NA 50% Rat Human -DTXSID9045182 Css NA 0.4305 mg/L PBTK NA 95% Rat Human +DTXSID9045182 TK.Half.Life NA 5.559 hours 1compartment NA NA Rat Human +DTXSID9045182 Css NA 0.08746 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045182 Css NA 0.3973 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045182 Css NA 0.06596 mg/L PBTK NA 50% Rat Human +DTXSID9045182 Css NA 0.2709 mg/L PBTK NA 95% Rat Human DTXSID9045184 Clint 38.94 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID9045184 Fup 0.04 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID9045184 Vd NA 1.665 L/kg 1compartment NA NA Human Human +DTXSID9045184 Vd NA 1.773 L/kg 1compartment NA NA Human Human DTXSID9045184 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045184 TK.Half.Life NA 5.631 hours 1compartment NA NA Human Human -DTXSID9045184 Css NA 0.07421 mg/L 3compartmentss NA 50% Human Human -DTXSID9045184 Css NA 0.6598 mg/L 3compartmentss NA 95% Human Human -DTXSID9045184 Css NA 0.0492 mg/L PBTK NA 50% Human Human -DTXSID9045184 Css NA 0.4139 mg/L PBTK NA 95% Human Human +DTXSID9045184 TK.Half.Life NA 6.129 hours 1compartment NA NA Human Human +DTXSID9045184 Css NA 0.4067 mg/L 3compartmentss NA 50% Human Human +DTXSID9045184 Css NA 3.582 mg/L 3compartmentss NA 95% Human Human +DTXSID9045184 Css NA 0.2845 mg/L PBTK NA 50% Human Human +DTXSID9045184 Css NA 2.507 mg/L PBTK NA 95% Human Human DTXSID9045184 Clint 2287 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat DTXSID9045184 Fup 0.022 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Rat -DTXSID9045184 Vd NA 0.9802 L/kg 1compartment NA NA Rat Rat +DTXSID9045184 Vd NA 1.049 L/kg 1compartment NA NA Rat Rat DTXSID9045184 Days.Css NA 0 Days PBTK NA NA Rat Rat -DTXSID9045184 TK.Half.Life NA 0.3836 hours 1compartment NA NA Rat Rat -DTXSID9045184 Css NA 0.006738 mg/L 3compartmentss NA 50% Rat Rat -DTXSID9045184 Css NA 0.06004 mg/L 3compartmentss NA 95% Rat Rat -DTXSID9045184 Css NA 0.004284 mg/L PBTK NA 50% Rat Rat -DTXSID9045184 Css NA 0.03574 mg/L PBTK NA 95% Rat Rat -DTXSID9045186 Clint NA 0.04752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9045184 TK.Half.Life NA 0.4097 hours 1compartment NA NA Rat Rat +DTXSID9045184 Css NA 0.001198 mg/L 3compartmentss NA 50% Rat Rat +DTXSID9045184 Css NA 0.01094 mg/L 3compartmentss NA 95% Rat Rat +DTXSID9045184 Css NA 0.0008741 mg/L PBTK NA 50% Rat Rat +DTXSID9045184 Css NA 0.007938 mg/L PBTK NA 95% Rat Rat +DTXSID9045186 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9045186 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9045186 Vd NA 0.7101 L/kg 1compartment NA NA Human Human +DTXSID9045186 Vd NA 0.6272 L/kg 1compartment NA NA Human Human DTXSID9045186 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045186 TK.Half.Life NA 7.807 hours 1compartment NA NA Human Human -DTXSID9045186 Css NA 1.212 mg/L 3compartmentss NA 50% Human Human -DTXSID9045186 Css NA 7.579 mg/L 3compartmentss NA 95% Human Human -DTXSID9045186 Css NA 0.953 mg/L PBTK NA 50% Human Human -DTXSID9045186 Css NA 4.785 mg/L PBTK NA 95% Human Human -DTXSID9045186 Clint NA 0.04752 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9045186 TK.Half.Life NA 7.409 hours 1compartment NA NA Human Human +DTXSID9045186 Css NA 1.33 mg/L 3compartmentss NA 50% Human Human +DTXSID9045186 Css NA 8.246 mg/L 3compartmentss NA 95% Human Human +DTXSID9045186 Css NA 1.025 mg/L PBTK NA 50% Human Human +DTXSID9045186 Css NA 5.117 mg/L PBTK NA 95% Human Human +DTXSID9045186 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9045186 Fup 0.55 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9045186 Vd NA 0.7043 L/kg 1compartment NA NA Rat Human +DTXSID9045186 Vd NA 0.6313 L/kg 1compartment NA NA Rat Human DTXSID9045186 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045186 TK.Half.Life NA 2.725 hours 1compartment NA NA Rat Human -DTXSID9045186 Css NA 0.3409 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045186 Css NA 2.022 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045186 Css NA 0.258 mg/L PBTK NA 50% Rat Human -DTXSID9045186 Css NA 1.188 mg/L PBTK NA 95% Rat Human -DTXSID9045188 Clint NA 17.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045188 Fup NA 0.1708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045188 Vd NA 0.8269 L/kg 1compartment NA NA Human Human +DTXSID9045186 TK.Half.Life NA 2.533 hours 1compartment NA NA Rat Human +DTXSID9045186 Css NA 0.08156 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045186 Css NA 0.4822 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045186 Css NA 0.0623 mg/L PBTK NA 50% Rat Human +DTXSID9045186 Css NA 0.2908 mg/L PBTK NA 95% Rat Human +DTXSID9045188 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045188 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045188 Vd NA 1.203 L/kg 1compartment NA NA Human Human DTXSID9045188 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045188 TK.Half.Life NA 1.67 hours 1compartment NA NA Human Human -DTXSID9045188 Css NA 0.1687 mg/L 3compartmentss NA 50% Human Human -DTXSID9045188 Css NA 1.155 mg/L 3compartmentss NA 95% Human Human -DTXSID9045188 Css NA 0.1154 mg/L PBTK NA 50% Human Human -DTXSID9045188 Css NA 0.7427 mg/L PBTK NA 95% Human Human -DTXSID9045188 Clint NA 17.78 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045188 Fup NA 0.1708 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045188 Vd NA 0.7198 L/kg 1compartment NA NA Rat Human +DTXSID9045188 TK.Half.Life NA 2.195 hours 1compartment NA NA Human Human +DTXSID9045188 Css NA 0.1364 mg/L 3compartmentss NA 50% Human Human +DTXSID9045188 Css NA 0.9756 mg/L 3compartmentss NA 95% Human Human +DTXSID9045188 Css NA 0.111 mg/L PBTK NA 50% Human Human +DTXSID9045188 Css NA 0.6849 mg/L PBTK NA 95% Human Human +DTXSID9045188 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045188 Fup 0.465 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045188 Vd NA 1.097 L/kg 1compartment NA NA Rat Human DTXSID9045188 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045188 TK.Half.Life NA 0.8153 hours 1compartment NA NA Rat Human -DTXSID9045188 Css NA 0.09095 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045188 Css NA 0.4728 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045188 Css NA 0.059 mg/L PBTK NA 50% Rat Human -DTXSID9045188 Css NA 0.2906 mg/L PBTK NA 95% Rat Human -DTXSID9045215 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045215 Fup NA 0.3333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045215 Vd NA 0.4234 L/kg 1compartment NA NA Human Human -DTXSID9045215 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045215 TK.Half.Life NA 8.218 hours 1compartment NA NA Human Human -DTXSID9045215 Css NA 2.288 mg/L 3compartmentss NA 50% Human Human -DTXSID9045215 Css NA 9.098 mg/L 3compartmentss NA 95% Human Human -DTXSID9045215 Css NA 1.61 mg/L PBTK NA 50% Human Human -DTXSID9045215 Css NA 5.668 mg/L PBTK NA 95% Human Human -DTXSID9045215 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045215 Fup NA 0.3333 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045215 Vd NA 0.4313 L/kg 1compartment NA NA Rat Human +DTXSID9045188 TK.Half.Life NA 1.075 hours 1compartment NA NA Rat Human +DTXSID9045188 Css NA 0.01536 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045188 Css NA 0.08823 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045188 Css NA 0.01274 mg/L PBTK NA 50% Rat Human +DTXSID9045188 Css NA 0.05972 mg/L PBTK NA 95% Rat Human +DTXSID9045215 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045215 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045215 Vd NA 0.3881 L/kg 1compartment NA NA Human Human +DTXSID9045215 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9045215 TK.Half.Life NA 10.64 hours 1compartment NA NA Human Human +DTXSID9045215 Css NA 3.18 mg/L 3compartmentss NA 50% Human Human +DTXSID9045215 Css NA 12.03 mg/L 3compartmentss NA 95% Human Human +DTXSID9045215 Css NA 2.16 mg/L PBTK NA 50% Human Human +DTXSID9045215 Css NA 7.489 mg/L PBTK NA 95% Human Human +DTXSID9045215 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045215 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045215 Vd NA 0.391 L/kg 1compartment NA NA Rat Human DTXSID9045215 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045215 TK.Half.Life NA 2.852 hours 1compartment NA NA Rat Human -DTXSID9045215 Css NA 0.6336 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045215 Css NA 2.138 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045215 Css NA 0.4219 mg/L PBTK NA 50% Rat Human -DTXSID9045215 Css NA 1.246 mg/L PBTK NA 95% Rat Human -DTXSID9045217 Clint NA 2.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045217 Fup NA 0.078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045217 Vd NA 1.009 L/kg 1compartment NA NA Human Human -DTXSID9045217 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9045217 TK.Half.Life NA 19.73 hours 1compartment NA NA Human Human -DTXSID9045217 Css NA 3.062 mg/L 3compartmentss NA 50% Human Human -DTXSID9045217 Css NA 16.69 mg/L 3compartmentss NA 95% Human Human -DTXSID9045217 Css NA 1.965 mg/L PBTK NA 50% Human Human -DTXSID9045217 Css NA 10.04 mg/L PBTK NA 95% Human Human -DTXSID9045217 Clint NA 2.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045217 Fup NA 0.078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045217 Vd NA 0.7842 L/kg 1compartment NA NA Rat Human +DTXSID9045215 TK.Half.Life NA 3.654 hours 1compartment NA NA Rat Human +DTXSID9045215 Css NA 0.2073 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045215 Css NA 0.6461 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045215 Css NA 0.1375 mg/L PBTK NA 50% Rat Human +DTXSID9045215 Css NA 0.3854 mg/L PBTK NA 95% Rat Human +DTXSID9045217 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045217 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045217 Vd NA 1.287 L/kg 1compartment NA NA Human Human +DTXSID9045217 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045217 TK.Half.Life NA 7.509 hours 1compartment NA NA Human Human +DTXSID9045217 Css NA 0.7468 mg/L 3compartmentss NA 50% Human Human +DTXSID9045217 Css NA 5.063 mg/L 3compartmentss NA 95% Human Human +DTXSID9045217 Css NA 0.502 mg/L PBTK NA 50% Human Human +DTXSID9045217 Css NA 3.164 mg/L PBTK NA 95% Human Human +DTXSID9045217 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045217 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045217 Vd NA 1.003 L/kg 1compartment NA NA Rat Human DTXSID9045217 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045217 TK.Half.Life NA 7.894 hours 1compartment NA NA Rat Human -DTXSID9045217 Css NA 1.451 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045217 Css NA 6.162 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045217 Css NA 0.8714 mg/L PBTK NA 50% Rat Human -DTXSID9045217 Css NA 3.453 mg/L PBTK NA 95% Rat Human -DTXSID9045265 Clint NA 3.701 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045265 Fup NA 0.0561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045265 Vd NA 0.224 L/kg 1compartment NA NA Human Human +DTXSID9045217 TK.Half.Life NA 3.092 hours 1compartment NA NA Rat Human +DTXSID9045217 Css NA 0.09197 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045217 Css NA 0.4498 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045217 Css NA 0.06044 mg/L PBTK NA 50% Rat Human +DTXSID9045217 Css NA 0.2695 mg/L PBTK NA 95% Rat Human +DTXSID9045265 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045265 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045265 Vd NA 0.2778 L/kg 1compartment NA NA Human Human DTXSID9045265 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045265 TK.Half.Life NA 3.775 hours 1compartment NA NA Human Human -DTXSID9045265 Css NA 2.905 mg/L 3compartmentss NA 50% Human Human -DTXSID9045265 Css NA 17.58 mg/L 3compartmentss NA 95% Human Human -DTXSID9045265 Css NA 1.739 mg/L PBTK NA 50% Human Human -DTXSID9045265 Css NA 10.29 mg/L PBTK NA 95% Human Human -DTXSID9045265 Clint NA 3.701 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045265 Fup NA 0.0561 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045265 Vd NA 0.2216 L/kg 1compartment NA NA Rat Human +DTXSID9045265 TK.Half.Life NA 1.595 hours 1compartment NA NA Human Human +DTXSID9045265 Css NA 0.8059 mg/L 3compartmentss NA 50% Human Human +DTXSID9045265 Css NA 5.63 mg/L 3compartmentss NA 95% Human Human +DTXSID9045265 Css NA 0.5024 mg/L PBTK NA 50% Human Human +DTXSID9045265 Css NA 3.387 mg/L PBTK NA 95% Human Human +DTXSID9045265 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045265 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045265 Vd NA 0.2759 L/kg 1compartment NA NA Rat Human DTXSID9045265 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045265 TK.Half.Life NA 2.24 hours 1compartment NA NA Rat Human -DTXSID9045265 Css NA 1.485 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045265 Css NA 6.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045265 Css NA 0.8304 mg/L PBTK NA 50% Rat Human -DTXSID9045265 Css NA 3.704 mg/L PBTK NA 95% Rat Human -DTXSID9045267 Clint NA 13.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045267 Fup NA 0.1544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045267 Vd NA 1.575 L/kg 1compartment NA NA Human Human +DTXSID9045265 TK.Half.Life NA 0.9606 hours 1compartment NA NA Rat Human +DTXSID9045265 Css NA 0.09903 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045265 Css NA 0.513 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045265 Css NA 0.0596 mg/L PBTK NA 50% Rat Human +DTXSID9045265 Css NA 0.2945 mg/L PBTK NA 95% Rat Human +DTXSID9045267 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045267 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045267 Vd NA 1.391 L/kg 1compartment NA NA Human Human DTXSID9045267 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045267 TK.Half.Life NA 4.658 hours 1compartment NA NA Human Human -DTXSID9045267 Css NA 0.3068 mg/L 3compartmentss NA 50% Human Human -DTXSID9045267 Css NA 2.172 mg/L 3compartmentss NA 95% Human Human -DTXSID9045267 Css NA 0.2114 mg/L PBTK NA 50% Human Human -DTXSID9045267 Css NA 1.409 mg/L PBTK NA 95% Human Human -DTXSID9045267 Clint NA 13.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045267 Fup NA 0.1544 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045267 Vd NA 1.222 L/kg 1compartment NA NA Rat Human +DTXSID9045267 TK.Half.Life NA 5.074 hours 1compartment NA NA Human Human +DTXSID9045267 Css NA 0.3525 mg/L 3compartmentss NA 50% Human Human +DTXSID9045267 Css NA 2.076 mg/L 3compartmentss NA 95% Human Human +DTXSID9045267 Css NA 0.2538 mg/L PBTK NA 50% Human Human +DTXSID9045267 Css NA 1.389 mg/L PBTK NA 95% Human Human +DTXSID9045267 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045267 Fup 0.22 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045267 Vd NA 1.111 L/kg 1compartment NA NA Rat Human DTXSID9045267 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045267 TK.Half.Life NA 1.796 hours 1compartment NA NA Rat Human -DTXSID9045267 Css NA 0.1688 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045267 Css NA 0.8911 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045267 Css NA 0.1111 mg/L PBTK NA 50% Rat Human -DTXSID9045267 Css NA 0.5384 mg/L PBTK NA 95% Rat Human -DTXSID9045342 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045342 Fup NA 0.952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045342 Vd NA 0.5361 L/kg 1compartment NA NA Human Human +DTXSID9045267 TK.Half.Life NA 2.082 hours 1compartment NA NA Rat Human +DTXSID9045267 Css NA 0.04187 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045267 Css NA 0.1822 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045267 Css NA 0.03003 mg/L PBTK NA 50% Rat Human +DTXSID9045267 Css NA 0.1168 mg/L PBTK NA 95% Rat Human +DTXSID9045342 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045342 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045342 Vd NA 0.369 L/kg 1compartment NA NA Human Human DTXSID9045342 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045342 TK.Half.Life NA 3.642 hours 1compartment NA NA Human Human -DTXSID9045342 Css NA 0.9912 mg/L 3compartmentss NA 50% Human Human -DTXSID9045342 Css NA 5.25 mg/L 3compartmentss NA 95% Human Human -DTXSID9045342 Css NA 0.7502 mg/L PBTK NA 50% Human Human -DTXSID9045342 Css NA 3.266 mg/L PBTK NA 95% Human Human -DTXSID9045342 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045342 Fup NA 0.952 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045342 Vd NA 0.5583 L/kg 1compartment NA NA Rat Human +DTXSID9045342 TK.Half.Life NA 3.934 hours 1compartment NA NA Human Human +DTXSID9045342 Css NA 0.7409 mg/L 3compartmentss NA 50% Human Human +DTXSID9045342 Css NA 4.914 mg/L 3compartmentss NA 95% Human Human +DTXSID9045342 Css NA 0.5258 mg/L PBTK NA 50% Human Human +DTXSID9045342 Css NA 2.955 mg/L PBTK NA 95% Human Human +DTXSID9045342 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045342 Fup 0.607 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045342 Vd NA 0.3957 L/kg 1compartment NA NA Rat Human DTXSID9045342 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045342 TK.Half.Life NA 1.293 hours 1compartment NA NA Rat Human -DTXSID9045342 Css NA 0.2524 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045342 Css NA 1.284 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045342 Css NA 0.1844 mg/L PBTK NA 50% Rat Human -DTXSID9045342 Css NA 0.7531 mg/L PBTK NA 95% Rat Human -DTXSID9045344 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045344 Fup NA 0.4762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045344 Vd NA 1.266 L/kg 1compartment NA NA Human Human -DTXSID9045344 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9045344 TK.Half.Life NA 17.2 hours 1compartment NA NA Human Human -DTXSID9045344 Css NA 1.332 mg/L 3compartmentss NA 50% Human Human -DTXSID9045344 Css NA 6.989 mg/L 3compartmentss NA 95% Human Human -DTXSID9045344 Css NA 1.15 mg/L PBTK NA 50% Human Human -DTXSID9045344 Css NA 4.625 mg/L PBTK NA 95% Human Human -DTXSID9045344 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045344 Fup NA 0.4762 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045344 Vd NA 1.28 L/kg 1compartment NA NA Rat Human +DTXSID9045342 TK.Half.Life NA 1.437 hours 1compartment NA NA Rat Human +DTXSID9045342 Css NA 0.003925 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045342 Css NA 0.02663 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045342 Css NA 0.002668 mg/L PBTK NA 50% Rat Human +DTXSID9045342 Css NA 0.01547 mg/L PBTK NA 95% Rat Human +DTXSID9045344 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045344 Fup 0.393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045344 Vd NA 0.3413 L/kg 1compartment NA NA Human Human +DTXSID9045344 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045344 TK.Half.Life NA 5.617 hours 1compartment NA NA Human Human +DTXSID9045344 Css NA 1.683 mg/L 3compartmentss NA 50% Human Human +DTXSID9045344 Css NA 7.467 mg/L 3compartmentss NA 95% Human Human +DTXSID9045344 Css NA 1.145 mg/L PBTK NA 50% Human Human +DTXSID9045344 Css NA 4.549 mg/L PBTK NA 95% Human Human +DTXSID9045344 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045344 Fup 0.393 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045344 Vd NA 0.3534 L/kg 1compartment NA NA Rat Human DTXSID9045344 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045344 TK.Half.Life NA 5.924 hours 1compartment NA NA Rat Human -DTXSID9045344 Css NA 0.3554 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045344 Css NA 1.681 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045344 Css NA 0.2979 mg/L PBTK NA 50% Rat Human -DTXSID9045344 Css NA 1.05 mg/L PBTK NA 95% Rat Human -DTXSID9045346 Clint NA 3.311 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045346 Fup NA 0.3666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045346 Vd NA 0.4834 L/kg 1compartment NA NA Human Human +DTXSID9045344 TK.Half.Life NA 1.982 hours 1compartment NA NA Rat Human +DTXSID9045344 Css NA 0.03149 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045344 Css NA 0.1977 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045344 Css NA 0.0205 mg/L PBTK NA 50% Rat Human +DTXSID9045344 Css NA 0.1195 mg/L PBTK NA 95% Rat Human +DTXSID9045346 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045346 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045346 Vd NA 0.4589 L/kg 1compartment NA NA Human Human DTXSID9045346 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045346 TK.Half.Life NA 1.584 hours 1compartment NA NA Human Human -DTXSID9045346 Css NA 0.3305 mg/L 3compartmentss NA 50% Human Human -DTXSID9045346 Css NA 1.892 mg/L 3compartmentss NA 95% Human Human -DTXSID9045346 Css NA 0.2366 mg/L PBTK NA 50% Human Human -DTXSID9045346 Css NA 1.219 mg/L PBTK NA 95% Human Human -DTXSID9045346 Clint NA 3.311 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045346 Fup NA 0.3666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045346 Vd NA 0.4945 L/kg 1compartment NA NA Rat Human +DTXSID9045346 TK.Half.Life NA 1.087 hours 1compartment NA NA Human Human +DTXSID9045346 Css NA 0.2095 mg/L 3compartmentss NA 50% Human Human +DTXSID9045346 Css NA 1.286 mg/L 3compartmentss NA 95% Human Human +DTXSID9045346 Css NA 0.1451 mg/L PBTK NA 50% Human Human +DTXSID9045346 Css NA 0.8285 mg/L PBTK NA 95% Human Human +DTXSID9045346 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045346 Fup 0.332 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045346 Vd NA 0.469 L/kg 1compartment NA NA Rat Human DTXSID9045346 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045346 TK.Half.Life NA 0.9005 hours 1compartment NA NA Rat Human -DTXSID9045346 Css NA 0.1574 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045346 Css NA 0.6809 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045346 Css NA 0.107 mg/L PBTK NA 50% Rat Human -DTXSID9045346 Css NA 0.408 mg/L PBTK NA 95% Rat Human -DTXSID9045348 Clint NA 31.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045348 Fup NA 0.0178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045348 Vd NA 3.092 L/kg 1compartment NA NA Human Human -DTXSID9045348 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID9045348 TK.Half.Life NA 56.22 hours 1compartment NA NA Human Human -DTXSID9045348 Css NA 2.182 mg/L 3compartmentss NA 50% Human Human -DTXSID9045348 Css NA 14.31 mg/L 3compartmentss NA 95% Human Human -DTXSID9045348 Css NA 1.518 mg/L PBTK NA 50% Human Human -DTXSID9045348 Css NA 9.647 mg/L PBTK NA 95% Human Human -DTXSID9045348 Clint NA 31.93 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045348 Fup NA 0.0178 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045348 Vd NA 2.317 L/kg 1compartment NA NA Rat Human -DTXSID9045348 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9045348 TK.Half.Life NA 8.054 hours 1compartment NA NA Rat Human -DTXSID9045348 Css NA 1.237 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045348 Css NA 6.514 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045348 Css NA 0.8174 mg/L PBTK NA 50% Rat Human -DTXSID9045348 Css NA 4.142 mg/L PBTK NA 95% Rat Human -DTXSID9045390 Clint NA 24.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045390 Fup NA 0.2671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045390 Vd NA 2.328 L/kg 1compartment NA NA Human Human +DTXSID9045346 TK.Half.Life NA 0.629 hours 1compartment NA NA Rat Human +DTXSID9045346 Css NA 0.02432 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045346 Css NA 0.1169 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045346 Css NA 0.01677 mg/L PBTK NA 50% Rat Human +DTXSID9045346 Css NA 0.07219 mg/L PBTK NA 95% Rat Human +DTXSID9045348 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045348 Fup 0.0638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045348 Vd NA 1.933 L/kg 1compartment NA NA Human Human +DTXSID9045348 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045348 TK.Half.Life NA 8.485 hours 1compartment NA NA Human Human +DTXSID9045348 Css NA 0.536 mg/L 3compartmentss NA 50% Human Human +DTXSID9045348 Css NA 3.757 mg/L 3compartmentss NA 95% Human Human +DTXSID9045348 Css NA 0.3534 mg/L PBTK NA 50% Human Human +DTXSID9045348 Css NA 2.37 mg/L PBTK NA 95% Human Human +DTXSID9045348 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045348 Fup 0.0638 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045348 Vd NA 1.464 L/kg 1compartment NA NA Rat Human +DTXSID9045348 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045348 TK.Half.Life NA 2.91 hours 1compartment NA NA Rat Human +DTXSID9045348 Css NA 0.07012 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045348 Css NA 0.3897 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045348 Css NA 0.04548 mg/L PBTK NA 50% Rat Human +DTXSID9045348 Css NA 0.244 mg/L PBTK NA 95% Rat Human +DTXSID9045390 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045390 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045390 Vd NA 2.478 L/kg 1compartment NA NA Human Human DTXSID9045390 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045390 TK.Half.Life NA 2.817 hours 1compartment NA NA Human Human -DTXSID9045390 Css NA 0.06212 mg/L 3compartmentss NA 50% Human Human -DTXSID9045390 Css NA 0.474 mg/L 3compartmentss NA 95% Human Human -DTXSID9045390 Css NA 0.05539 mg/L PBTK NA 50% Human Human -DTXSID9045390 Css NA 0.3596 mg/L PBTK NA 95% Human Human -DTXSID9045390 Clint NA 24.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045390 Fup NA 0.2671 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045390 Vd NA 2.181 L/kg 1compartment NA NA Rat Human +DTXSID9045390 TK.Half.Life NA 4.606 hours 1compartment NA NA Human Human +DTXSID9045390 Css NA 0.1216 mg/L 3compartmentss NA 50% Human Human +DTXSID9045390 Css NA 0.8888 mg/L 3compartmentss NA 95% Human Human +DTXSID9045390 Css NA 0.1206 mg/L PBTK NA 50% Human Human +DTXSID9045390 Css NA 0.7254 mg/L PBTK NA 95% Human Human +DTXSID9045390 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045390 Fup 0.423 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045390 Vd NA 2.411 L/kg 1compartment NA NA Rat Human DTXSID9045390 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045390 TK.Half.Life NA 1.355 hours 1compartment NA NA Rat Human -DTXSID9045390 Css NA 0.03323 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045390 Css NA 0.1902 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045390 Css NA 0.02884 mg/L PBTK NA 50% Rat Human -DTXSID9045390 Css NA 0.1416 mg/L PBTK NA 95% Rat Human -DTXSID9045392 Clint NA 63.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045392 Fup NA 0.6719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045392 Vd NA 0.95 L/kg 1compartment NA NA Human Human -DTXSID9045392 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045392 TK.Half.Life NA 0.6527 hours 1compartment NA NA Human Human -DTXSID9045392 Css NA 0.01134 mg/L 3compartmentss NA 50% Human Human -DTXSID9045392 Css NA 0.1294 mg/L 3compartmentss NA 95% Human Human -DTXSID9045392 Css NA 0.009362 mg/L PBTK NA 50% Human Human -DTXSID9045392 Css NA 0.08826 mg/L PBTK NA 95% Human Human -DTXSID9045392 Clint NA 63.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045392 Fup NA 0.6719 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045392 Vd NA 0.9566 L/kg 1compartment NA NA Rat Human +DTXSID9045390 TK.Half.Life NA 2.432 hours 1compartment NA NA Rat Human +DTXSID9045390 Css NA 0.01394 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045390 Css NA 0.08028 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045390 Css NA 0.01407 mg/L PBTK NA 50% Rat Human +DTXSID9045390 Css NA 0.06132 mg/L PBTK NA 95% Rat Human +DTXSID9045392 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045392 Fup 0.61 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045392 Vd NA 1.116 L/kg 1compartment NA NA Human Human +DTXSID9045392 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9045392 TK.Half.Life NA 11.84 hours 1compartment NA NA Human Human +DTXSID9045392 Css NA 1.083 mg/L 3compartmentss NA 50% Human Human +DTXSID9045392 Css NA 7.999 mg/L 3compartmentss NA 95% Human Human +DTXSID9045392 Css NA 0.9354 mg/L PBTK NA 50% Human Human +DTXSID9045392 Css NA 5.098 mg/L PBTK NA 95% Human Human +DTXSID9045392 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045392 Fup 0.61 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045392 Vd NA 1.148 L/kg 1compartment NA NA Rat Human DTXSID9045392 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045392 TK.Half.Life NA 0.3015 hours 1compartment NA NA Rat Human -DTXSID9045392 Css NA 0.0058 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045392 Css NA 0.057 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045392 Css NA 0.004729 mg/L PBTK NA 50% Rat Human -DTXSID9045392 Css NA 0.03765 mg/L PBTK NA 95% Rat Human +DTXSID9045392 TK.Half.Life NA 4.148 hours 1compartment NA NA Rat Human +DTXSID9045392 Css NA 0.06583 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045392 Css NA 0.4595 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045392 Css NA 0.05715 mg/L PBTK NA 50% Rat Human +DTXSID9045392 Css NA 0.2855 mg/L PBTK NA 95% Rat Human DTXSID9045394 Clint NA 0.3303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9045394 Fup NA 0.2842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045394 Vd NA 0.4415 L/kg 1compartment NA NA Human Human +DTXSID9045394 Vd NA 0.4047 L/kg 1compartment NA NA Human Human DTXSID9045394 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045394 TK.Half.Life NA 6.418 hours 1compartment NA NA Human Human -DTXSID9045394 Css NA 1.685 mg/L 3compartmentss NA 50% Human Human -DTXSID9045394 Css NA 6.624 mg/L 3compartmentss NA 95% Human Human -DTXSID9045394 Css NA 1.168 mg/L PBTK NA 50% Human Human -DTXSID9045394 Css NA 4.141 mg/L PBTK NA 95% Human Human +DTXSID9045394 TK.Half.Life NA 5.728 hours 1compartment NA NA Human Human +DTXSID9045394 Css NA 0.8852 mg/L 3compartmentss NA 50% Human Human +DTXSID9045394 Css NA 3.862 mg/L 3compartmentss NA 95% Human Human +DTXSID9045394 Css NA 0.6062 mg/L PBTK NA 50% Human Human +DTXSID9045394 Css NA 2.392 mg/L PBTK NA 95% Human Human DTXSID9045394 Clint NA 0.3303 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9045394 Fup NA 0.2842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045394 Vd NA 0.4517 L/kg 1compartment NA NA Rat Human +DTXSID9045394 Vd NA 0.4186 L/kg 1compartment NA NA Rat Human DTXSID9045394 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045394 TK.Half.Life NA 2.744 hours 1compartment NA NA Rat Human -DTXSID9045394 Css NA 0.581 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045394 Css NA 2.004 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045394 Css NA 0.3829 mg/L PBTK NA 50% Rat Human -DTXSID9045394 Css NA 1.165 mg/L PBTK NA 95% Rat Human -DTXSID9045398 Clint NA 36.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045398 Fup NA 0.3732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045398 Vd NA 1.214 L/kg 1compartment NA NA Human Human -DTXSID9045398 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045398 TK.Half.Life NA 1.183 hours 1compartment NA NA Human Human -DTXSID9045398 Css NA 0.0347 mg/L 3compartmentss NA 50% Human Human -DTXSID9045398 Css NA 0.2539 mg/L 3compartmentss NA 95% Human Human -DTXSID9045398 Css NA 0.02704 mg/L PBTK NA 50% Human Human -DTXSID9045398 Css NA 0.1799 mg/L PBTK NA 95% Human Human -DTXSID9045398 Clint NA 36.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045398 Fup NA 0.3732 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045398 Vd NA 1.036 L/kg 1compartment NA NA Rat Human +DTXSID9045394 TK.Half.Life NA 2.503 hours 1compartment NA NA Rat Human +DTXSID9045394 Css NA 0.005964 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045394 Css NA 0.02626 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045394 Css NA 0.003901 mg/L PBTK NA 50% Rat Human +DTXSID9045394 Css NA 0.01544 mg/L PBTK NA 95% Rat Human +DTXSID9045398 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045398 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045398 Vd NA 1.109 L/kg 1compartment NA NA Human Human +DTXSID9045398 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9045398 TK.Half.Life NA 16.39 hours 1compartment NA NA Human Human +DTXSID9045398 Css NA 1.297 mg/L 3compartmentss NA 50% Human Human +DTXSID9045398 Css NA 6.319 mg/L 3compartmentss NA 95% Human Human +DTXSID9045398 Css NA 1.06 mg/L PBTK NA 50% Human Human +DTXSID9045398 Css NA 4.159 mg/L PBTK NA 95% Human Human +DTXSID9045398 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045398 Fup 0.473 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045398 Vd NA 0.9893 L/kg 1compartment NA NA Rat Human DTXSID9045398 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045398 TK.Half.Life NA 0.4888 hours 1compartment NA NA Rat Human -DTXSID9045398 Css NA 0.01852 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045398 Css NA 0.1124 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045398 Css NA 0.01395 mg/L PBTK NA 50% Rat Human -DTXSID9045398 Css NA 0.07587 mg/L PBTK NA 95% Rat Human -DTXSID9045425 Clint NA 50.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045425 Fup NA 0.1338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045425 Vd NA 1.356 L/kg 1compartment NA NA Human Human +DTXSID9045398 TK.Half.Life NA 4.699 hours 1compartment NA NA Rat Human +DTXSID9045398 Css NA 0.03138 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045398 Css NA 0.2088 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045398 Css NA 0.02534 mg/L PBTK NA 50% Rat Human +DTXSID9045398 Css NA 0.1406 mg/L PBTK NA 95% Rat Human +DTXSID9045425 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045425 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045425 Vd NA 1.296 L/kg 1compartment NA NA Human Human DTXSID9045425 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045425 TK.Half.Life NA 1.727 hours 1compartment NA NA Human Human -DTXSID9045425 Css NA 0.07753 mg/L 3compartmentss NA 50% Human Human -DTXSID9045425 Css NA 0.6765 mg/L 3compartmentss NA 95% Human Human -DTXSID9045425 Css NA 0.05628 mg/L PBTK NA 50% Human Human -DTXSID9045425 Css NA 0.4388 mg/L PBTK NA 95% Human Human -DTXSID9045425 Clint NA 50.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045425 Fup NA 0.1338 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045425 Vd NA 1.32 L/kg 1compartment NA NA Rat Human +DTXSID9045425 TK.Half.Life NA 5.023 hours 1compartment NA NA Human Human +DTXSID9045425 Css NA 0.34 mg/L 3compartmentss NA 50% Human Human +DTXSID9045425 Css NA 1.924 mg/L 3compartmentss NA 95% Human Human +DTXSID9045425 Css NA 0.2403 mg/L PBTK NA 50% Human Human +DTXSID9045425 Css NA 1.278 mg/L PBTK NA 95% Human Human +DTXSID9045425 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045425 Fup 0.201 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045425 Vd NA 1.029 L/kg 1compartment NA NA Rat Human DTXSID9045425 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045425 TK.Half.Life NA 0.8996 hours 1compartment NA NA Rat Human -DTXSID9045425 Css NA 0.0434 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045425 Css NA 0.2886 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045425 Css NA 0.02992 mg/L PBTK NA 50% Rat Human -DTXSID9045425 Css NA 0.1834 mg/L PBTK NA 95% Rat Human -DTXSID9045429 Clint NA 3.329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045429 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045429 Vd NA 0.767 L/kg 1compartment NA NA Human Human +DTXSID9045425 TK.Half.Life NA 2.083 hours 1compartment NA NA Rat Human +DTXSID9045425 Css NA 0.01504 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045425 Css NA 0.1004 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045425 Css NA 0.01053 mg/L PBTK NA 50% Rat Human +DTXSID9045425 Css NA 0.06486 mg/L PBTK NA 95% Rat Human +DTXSID9045429 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045429 Fup 0.734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045429 Vd NA 0.6091 L/kg 1compartment NA NA Human Human DTXSID9045429 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045429 TK.Half.Life NA 1.071 hours 1compartment NA NA Human Human -DTXSID9045429 Css NA 0.1331 mg/L 3compartmentss NA 50% Human Human -DTXSID9045429 Css NA 1.085 mg/L 3compartmentss NA 95% Human Human -DTXSID9045429 Css NA 0.11 mg/L PBTK NA 50% Human Human -DTXSID9045429 Css NA 0.7711 mg/L PBTK NA 95% Human Human -DTXSID9045429 Clint NA 3.329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045429 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045429 Vd NA 0.807 L/kg 1compartment NA NA Rat Human +DTXSID9045429 TK.Half.Life NA 5.369 hours 1compartment NA NA Human Human +DTXSID9045429 Css NA 0.9382 mg/L 3compartmentss NA 50% Human Human +DTXSID9045429 Css NA 5.799 mg/L 3compartmentss NA 95% Human Human +DTXSID9045429 Css NA 0.742 mg/L PBTK NA 50% Human Human +DTXSID9045429 Css NA 3.608 mg/L PBTK NA 95% Human Human +DTXSID9045429 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045429 Fup 0.734 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045429 Vd NA 0.6457 L/kg 1compartment NA NA Rat Human DTXSID9045429 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045429 TK.Half.Life NA 0.5884 hours 1compartment NA NA Rat Human -DTXSID9045429 Css NA 0.05908 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045429 Css NA 0.3953 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045429 Css NA 0.04872 mg/L PBTK NA 50% Rat Human -DTXSID9045429 Css NA 0.2444 mg/L PBTK NA 95% Rat Human -DTXSID9045479 Clint NA 4.202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045479 Fup NA 0.9573 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045479 Vd NA 0.7055 L/kg 1compartment NA NA Human Human +DTXSID9045429 TK.Half.Life NA 1.939 hours 1compartment NA NA Rat Human +DTXSID9045429 Css NA 0.02405 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045429 Css NA 0.1845 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045429 Css NA 0.01858 mg/L PBTK NA 50% Rat Human +DTXSID9045429 Css NA 0.1161 mg/L PBTK NA 95% Rat Human +DTXSID9045479 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045479 Fup 0.461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045479 Vd NA 0.4413 L/kg 1compartment NA NA Human Human DTXSID9045479 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045479 TK.Half.Life NA 0.9173 hours 1compartment NA NA Human Human -DTXSID9045479 Css NA 0.122 mg/L 3compartmentss NA 50% Human Human -DTXSID9045479 Css NA 0.8937 mg/L 3compartmentss NA 95% Human Human -DTXSID9045479 Css NA 0.09687 mg/L PBTK NA 50% Human Human -DTXSID9045479 Css NA 0.6044 mg/L PBTK NA 95% Human Human -DTXSID9045479 Clint NA 4.202 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045479 Fup NA 0.9573 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045479 Vd NA 0.7379 L/kg 1compartment NA NA Rat Human +DTXSID9045479 TK.Half.Life NA 6.194 hours 1compartment NA NA Human Human +DTXSID9045479 Css NA 1.41 mg/L 3compartmentss NA 50% Human Human +DTXSID9045479 Css NA 6.564 mg/L 3compartmentss NA 95% Human Human +DTXSID9045479 Css NA 1.007 mg/L PBTK NA 50% Human Human +DTXSID9045479 Css NA 4.116 mg/L PBTK NA 95% Human Human +DTXSID9045479 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045479 Fup 0.461 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045479 Vd NA 0.4645 L/kg 1compartment NA NA Rat Human DTXSID9045479 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045479 TK.Half.Life NA 0.5005 hours 1compartment NA NA Rat Human -DTXSID9045479 Css NA 0.05542 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045479 Css NA 0.3506 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045479 Css NA 0.04338 mg/L PBTK NA 50% Rat Human -DTXSID9045479 Css NA 0.2188 mg/L PBTK NA 95% Rat Human -DTXSID9045500 Clint NA 12.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045500 Fup NA 0.1566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045500 Vd NA 0.3779 L/kg 1compartment NA NA Human Human +DTXSID9045479 TK.Half.Life NA 2.222 hours 1compartment NA NA Rat Human +DTXSID9045479 Css NA 0.03482 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045479 Css NA 0.2142 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045479 Css NA 0.02424 mg/L PBTK NA 50% Rat Human +DTXSID9045479 Css NA 0.1327 mg/L PBTK NA 95% Rat Human +DTXSID9045500 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045500 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045500 Vd NA 0.5293 L/kg 1compartment NA NA Human Human DTXSID9045500 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045500 TK.Half.Life NA 1.035 hours 1compartment NA NA Human Human -DTXSID9045500 Css NA 0.2978 mg/L 3compartmentss NA 50% Human Human -DTXSID9045500 Css NA 2.09 mg/L 3compartmentss NA 95% Human Human -DTXSID9045500 Css NA 0.1891 mg/L PBTK NA 50% Human Human -DTXSID9045500 Css NA 1.28 mg/L PBTK NA 95% Human Human -DTXSID9045500 Clint NA 12.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045500 Fup NA 0.1566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045500 Vd NA 0.3698 L/kg 1compartment NA NA Rat Human +DTXSID9045500 TK.Half.Life NA 1.384 hours 1compartment NA NA Human Human +DTXSID9045500 Css NA 0.2334 mg/L 3compartmentss NA 50% Human Human +DTXSID9045500 Css NA 1.441 mg/L 3compartmentss NA 95% Human Human +DTXSID9045500 Css NA 0.1631 mg/L PBTK NA 50% Human Human +DTXSID9045500 Css NA 0.9354 mg/L PBTK NA 95% Human Human +DTXSID9045500 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045500 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045500 Vd NA 0.517 L/kg 1compartment NA NA Rat Human DTXSID9045500 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045500 TK.Half.Life NA 0.5965 hours 1compartment NA NA Rat Human -DTXSID9045500 Css NA 0.1601 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045500 Css NA 0.8618 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045500 Css NA 0.09682 mg/L PBTK NA 50% Rat Human -DTXSID9045500 Css NA 0.4949 mg/L PBTK NA 95% Rat Human -DTXSID9045502 Clint NA 19.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045502 Fup NA 0.1322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045502 Vd NA 2.367 L/kg 1compartment NA NA Human Human +DTXSID9045500 TK.Half.Life NA 0.7714 hours 1compartment NA NA Rat Human +DTXSID9045500 Css NA 0.02778 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045500 Css NA 0.1303 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045500 Css NA 0.01917 mg/L PBTK NA 50% Rat Human +DTXSID9045500 Css NA 0.08144 mg/L PBTK NA 95% Rat Human +DTXSID9045502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045502 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045502 Vd NA 1.76 L/kg 1compartment NA NA Human Human DTXSID9045502 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045502 TK.Half.Life NA 8.492 hours 1compartment NA NA Human Human -DTXSID9045502 Css NA 0.3872 mg/L 3compartmentss NA 50% Human Human -DTXSID9045502 Css NA 2.575 mg/L 3compartmentss NA 95% Human Human -DTXSID9045502 Css NA 0.2702 mg/L PBTK NA 50% Human Human -DTXSID9045502 Css NA 1.693 mg/L PBTK NA 95% Human Human -DTXSID9045502 Clint NA 19.33 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045502 Fup NA 0.1322 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045502 Vd NA 1.792 L/kg 1compartment NA NA Rat Human +DTXSID9045502 TK.Half.Life NA 5.115 hours 1compartment NA NA Human Human +DTXSID9045502 Css NA 0.3083 mg/L 3compartmentss NA 50% Human Human +DTXSID9045502 Css NA 2.306 mg/L 3compartmentss NA 95% Human Human +DTXSID9045502 Css NA 0.2059 mg/L PBTK NA 50% Human Human +DTXSID9045502 Css NA 1.468 mg/L PBTK NA 95% Human Human +DTXSID9045502 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045502 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045502 Vd NA 1.34 L/kg 1compartment NA NA Rat Human DTXSID9045502 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045502 TK.Half.Life NA 2.423 hours 1compartment NA NA Rat Human -DTXSID9045502 Css NA 0.2153 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045502 Css NA 1.075 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045502 Css NA 0.143 mg/L PBTK NA 50% Rat Human -DTXSID9045502 Css NA 0.6854 mg/L PBTK NA 95% Rat Human -DTXSID9045506 Clint NA 0.2046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045506 Fup NA 0.1437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045506 Vd NA 0.3588 L/kg 1compartment NA NA Human Human -DTXSID9045506 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9045506 TK.Half.Life NA 12.12 hours 1compartment NA NA Human Human -DTXSID9045506 Css NA 4.815 mg/L 3compartmentss NA 50% Human Human -DTXSID9045506 Css NA 22.27 mg/L 3compartmentss NA 95% Human Human -DTXSID9045506 Css NA 3.029 mg/L PBTK NA 50% Human Human -DTXSID9045506 Css NA 13.31 mg/L PBTK NA 95% Human Human -DTXSID9045506 Clint NA 0.2046 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045506 Fup NA 0.1437 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045506 Vd NA 0.3367 L/kg 1compartment NA NA Rat Human +DTXSID9045502 TK.Half.Life NA 1.841 hours 1compartment NA NA Rat Human +DTXSID9045502 Css NA 0.03996 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045502 Css NA 0.2231 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045502 Css NA 0.02646 mg/L PBTK NA 50% Rat Human +DTXSID9045502 Css NA 0.1399 mg/L PBTK NA 95% Rat Human +DTXSID9045506 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045506 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045506 Vd NA 0.4525 L/kg 1compartment NA NA Human Human +DTXSID9045506 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045506 TK.Half.Life NA 1.385 hours 1compartment NA NA Human Human +DTXSID9045506 Css NA 0.2848 mg/L 3compartmentss NA 50% Human Human +DTXSID9045506 Css NA 1.738 mg/L 3compartmentss NA 95% Human Human +DTXSID9045506 Css NA 0.1982 mg/L PBTK NA 50% Human Human +DTXSID9045506 Css NA 1.112 mg/L PBTK NA 95% Human Human +DTXSID9045506 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045506 Fup 0.236 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045506 Vd NA 0.4535 L/kg 1compartment NA NA Rat Human DTXSID9045506 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045506 TK.Half.Life NA 4.438 hours 1compartment NA NA Rat Human -DTXSID9045506 Css NA 1.605 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045506 Css NA 6.254 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045506 Css NA 0.9466 mg/L PBTK NA 50% Rat Human -DTXSID9045506 Css NA 3.458 mg/L PBTK NA 95% Rat Human -DTXSID9045508 Clint NA 32.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045508 Fup NA 0.0419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045508 Vd NA 2.009 L/kg 1compartment NA NA Human Human +DTXSID9045506 TK.Half.Life NA 0.8085 hours 1compartment NA NA Rat Human +DTXSID9045506 Css NA 0.03416 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045506 Css NA 0.1503 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045506 Css NA 0.02337 mg/L PBTK NA 50% Rat Human +DTXSID9045506 Css NA 0.0935 mg/L PBTK NA 95% Rat Human +DTXSID9045508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045508 Fup 0.0648 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045508 Vd NA 0.6681 L/kg 1compartment NA NA Human Human DTXSID9045508 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045508 TK.Half.Life NA 8.858 hours 1compartment NA NA Human Human -DTXSID9045508 Css NA 0.5668 mg/L 3compartmentss NA 50% Human Human -DTXSID9045508 Css NA 4.06 mg/L 3compartmentss NA 95% Human Human -DTXSID9045508 Css NA 0.371 mg/L PBTK NA 50% Human Human -DTXSID9045508 Css NA 2.545 mg/L PBTK NA 95% Human Human -DTXSID9045508 Clint NA 32.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045508 Fup NA 0.0419 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045508 Vd NA 1.502 L/kg 1compartment NA NA Rat Human +DTXSID9045508 TK.Half.Life NA 2.269 hours 1compartment NA NA Human Human +DTXSID9045508 Css NA 0.4025 mg/L 3compartmentss NA 50% Human Human +DTXSID9045508 Css NA 3.154 mg/L 3compartmentss NA 95% Human Human +DTXSID9045508 Css NA 0.276 mg/L PBTK NA 50% Human Human +DTXSID9045508 Css NA 2.004 mg/L PBTK NA 95% Human Human +DTXSID9045508 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045508 Fup 0.0648 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045508 Vd NA 0.6067 L/kg 1compartment NA NA Rat Human DTXSID9045508 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045508 TK.Half.Life NA 2.885 hours 1compartment NA NA Rat Human -DTXSID9045508 Css NA 0.3184 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045508 Css NA 1.748 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045508 Css NA 0.1959 mg/L PBTK NA 50% Rat Human -DTXSID9045508 Css NA 1.07 mg/L PBTK NA 95% Rat Human -DTXSID9045550 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045550 Fup NA 0.5801 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045550 Vd NA 0.4841 L/kg 1compartment NA NA Human Human +DTXSID9045508 TK.Half.Life NA 1.265 hours 1compartment NA NA Rat Human +DTXSID9045508 Css NA 0.05195 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045508 Css NA 0.3237 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045508 Css NA 0.03505 mg/L PBTK NA 50% Rat Human +DTXSID9045508 Css NA 0.2028 mg/L PBTK NA 95% Rat Human +DTXSID9045550 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045550 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045550 Vd NA 0.4638 L/kg 1compartment NA NA Human Human DTXSID9045550 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045550 TK.Half.Life NA 5.398 hours 1compartment NA NA Human Human -DTXSID9045550 Css NA 1.368 mg/L 3compartmentss NA 50% Human Human -DTXSID9045550 Css NA 9.031 mg/L 3compartmentss NA 95% Human Human -DTXSID9045550 Css NA 1.012 mg/L PBTK NA 50% Human Human -DTXSID9045550 Css NA 5.523 mg/L PBTK NA 95% Human Human -DTXSID9045550 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045550 Fup NA 0.5801 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045550 Vd NA 0.5068 L/kg 1compartment NA NA Rat Human +DTXSID9045550 TK.Half.Life NA 5.955 hours 1compartment NA NA Human Human +DTXSID9045550 Css NA 0.8116 mg/L 3compartmentss NA 50% Human Human +DTXSID9045550 Css NA 4.561 mg/L 3compartmentss NA 95% Human Human +DTXSID9045550 Css NA 0.5916 mg/L PBTK NA 50% Human Human +DTXSID9045550 Css NA 2.853 mg/L PBTK NA 95% Human Human +DTXSID9045550 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045550 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045550 Vd NA 0.482 L/kg 1compartment NA NA Rat Human DTXSID9045550 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045550 TK.Half.Life NA 1.926 hours 1compartment NA NA Rat Human -DTXSID9045550 Css NA 0.3633 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045550 Css NA 2.203 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045550 Css NA 0.2554 mg/L PBTK NA 50% Rat Human -DTXSID9045550 Css NA 1.262 mg/L PBTK NA 95% Rat Human -DTXSID9045552 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9045550 TK.Half.Life NA 2.109 hours 1compartment NA NA Rat Human +DTXSID9045550 Css NA 0.004426 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045550 Css NA 0.02439 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045550 Css NA 0.003063 mg/L PBTK NA 50% Rat Human +DTXSID9045550 Css NA 0.01455 mg/L PBTK NA 95% Rat Human +DTXSID9045552 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9045552 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9045552 Vd NA 0.4666 L/kg 1compartment NA NA Human Human -DTXSID9045552 Days.Css NA 35 Days PBTK NA NA Human Human -DTXSID9045552 TK.Half.Life NA 156.1 hours 1compartment NA NA Human Human -DTXSID9045552 Css NA 56.96 mg/L 3compartmentss NA 50% Human Human -DTXSID9045552 Css NA 343.1 mg/L 3compartmentss NA 95% Human Human -DTXSID9045552 Css NA 33.79 mg/L PBTK NA 50% Human Human -DTXSID9045552 Css NA 200.8 mg/L PBTK NA 95% Human Human -DTXSID9045552 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9045552 Vd NA 0.7974 L/kg 1compartment NA NA Human Human +DTXSID9045552 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045552 TK.Half.Life NA 7.048 hours 1compartment NA NA Human Human +DTXSID9045552 Css NA 1.28 mg/L 3compartmentss NA 50% Human Human +DTXSID9045552 Css NA 12.15 mg/L 3compartmentss NA 95% Human Human +DTXSID9045552 Css NA 0.7717 mg/L PBTK NA 50% Human Human +DTXSID9045552 Css NA 7.181 mg/L PBTK NA 95% Human Human +DTXSID9045552 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9045552 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9045552 Vd NA 0.3649 L/kg 1compartment NA NA Rat Human -DTXSID9045552 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID9045552 TK.Half.Life NA 40.56 hours 1compartment NA NA Rat Human -DTXSID9045552 Css NA 16.16 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045552 Css NA 83.95 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045552 Css NA 8.961 mg/L PBTK NA 50% Rat Human -DTXSID9045552 Css NA 45.58 mg/L PBTK NA 95% Rat Human -DTXSID9045556 Clint NA 15.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045556 Fup NA 0.26 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045556 Vd NA 2.774 L/kg 1compartment NA NA Human Human +DTXSID9045552 Vd NA 0.5966 L/kg 1compartment NA NA Rat Human +DTXSID9045552 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045552 TK.Half.Life NA 3.225 hours 1compartment NA NA Rat Human +DTXSID9045552 Css NA 0.06312 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045552 Css NA 0.6799 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045552 Css NA 0.0367 mg/L PBTK NA 50% Rat Human +DTXSID9045552 Css NA 0.3828 mg/L PBTK NA 95% Rat Human +DTXSID9045556 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045556 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045556 Vd NA 0.8888 L/kg 1compartment NA NA Human Human DTXSID9045556 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045556 TK.Half.Life NA 7.205 hours 1compartment NA NA Human Human -DTXSID9045556 Css NA 0.2164 mg/L 3compartmentss NA 50% Human Human -DTXSID9045556 Css NA 1.317 mg/L 3compartmentss NA 95% Human Human -DTXSID9045556 Css NA 0.172 mg/L PBTK NA 50% Human Human -DTXSID9045556 Css NA 0.9865 mg/L PBTK NA 95% Human Human -DTXSID9045556 Clint NA 15.05 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045556 Fup NA 0.26 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045556 Vd NA 2.251 L/kg 1compartment NA NA Rat Human +DTXSID9045556 TK.Half.Life NA 1.699 hours 1compartment NA NA Human Human +DTXSID9045556 Css NA 0.1471 mg/L 3compartmentss NA 50% Human Human +DTXSID9045556 Css NA 0.9903 mg/L 3compartmentss NA 95% Human Human +DTXSID9045556 Css NA 0.1134 mg/L PBTK NA 50% Human Human +DTXSID9045556 Css NA 0.6848 mg/L PBTK NA 95% Human Human +DTXSID9045556 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045556 Fup 0.427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045556 Vd NA 0.893 L/kg 1compartment NA NA Rat Human DTXSID9045556 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045556 TK.Half.Life NA 2.217 hours 1compartment NA NA Rat Human -DTXSID9045556 Css NA 0.1154 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045556 Css NA 0.5416 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045556 Css NA 0.0888 mg/L PBTK NA 50% Rat Human -DTXSID9045556 Css NA 0.389 mg/L PBTK NA 95% Rat Human -DTXSID9045558 Clint NA 11.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045558 Fup NA 0.1095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045558 Vd NA 3.053 L/kg 1compartment NA NA Human Human -DTXSID9045558 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9045558 TK.Half.Life NA 32.96 hours 1compartment NA NA Human Human -DTXSID9045558 Css NA 1.264 mg/L 3compartmentss NA 50% Human Human -DTXSID9045558 Css NA 7.762 mg/L 3compartmentss NA 95% Human Human -DTXSID9045558 Css NA 0.9198 mg/L PBTK NA 50% Human Human -DTXSID9045558 Css NA 5.353 mg/L PBTK NA 95% Human Human -DTXSID9045558 Clint NA 11.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045558 Fup NA 0.1095 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045558 Vd NA 2.374 L/kg 1compartment NA NA Rat Human -DTXSID9045558 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9045558 TK.Half.Life NA 6.652 hours 1compartment NA NA Rat Human -DTXSID9045558 Css NA 0.6959 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045558 Css NA 3.165 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045558 Css NA 0.4858 mg/L PBTK NA 50% Rat Human -DTXSID9045558 Css NA 2.126 mg/L PBTK NA 95% Rat Human -DTXSID9045631 Clint NA 22.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045631 Fup NA 0.0248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045631 Vd NA 2.965 L/kg 1compartment NA NA Human Human -DTXSID9045631 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID9045631 TK.Half.Life NA 49.44 hours 1compartment NA NA Human Human -DTXSID9045631 Css NA 2.138 mg/L 3compartmentss NA 50% Human Human -DTXSID9045631 Css NA 13.33 mg/L 3compartmentss NA 95% Human Human -DTXSID9045631 Css NA 1.466 mg/L PBTK NA 50% Human Human -DTXSID9045631 Css NA 8.907 mg/L PBTK NA 95% Human Human -DTXSID9045631 Clint NA 22.89 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045631 Fup NA 0.0248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045631 Vd NA 2.221 L/kg 1compartment NA NA Rat Human -DTXSID9045631 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9045631 TK.Half.Life NA 8.276 hours 1compartment NA NA Rat Human -DTXSID9045631 Css NA 1.193 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045631 Css NA 6.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045631 Css NA 0.7805 mg/L PBTK NA 50% Rat Human -DTXSID9045631 Css NA 4.117 mg/L PBTK NA 95% Rat Human -DTXSID9045633 Clint NA 68.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045633 Fup NA 0.0771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045633 Vd NA 2.65 L/kg 1compartment NA NA Human Human -DTXSID9045633 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045633 TK.Half.Life NA 6.633 hours 1compartment NA NA Human Human -DTXSID9045633 Css NA 0.2348 mg/L 3compartmentss NA 50% Human Human -DTXSID9045633 Css NA 1.594 mg/L 3compartmentss NA 95% Human Human -DTXSID9045633 Css NA 0.1612 mg/L PBTK NA 50% Human Human -DTXSID9045633 Css NA 1.05 mg/L PBTK NA 95% Human Human -DTXSID9045633 Clint NA 68.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045633 Fup NA 0.0771 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045633 Vd NA 1.99 L/kg 1compartment NA NA Rat Human +DTXSID9045556 TK.Half.Life NA 0.9524 hours 1compartment NA NA Rat Human +DTXSID9045556 Css NA 0.0168 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045556 Css NA 0.0929 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045556 Css NA 0.01311 mg/L PBTK NA 50% Rat Human +DTXSID9045556 Css NA 0.06064 mg/L PBTK NA 95% Rat Human +DTXSID9045558 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045558 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045558 Vd NA 0.3059 L/kg 1compartment NA NA Human Human +DTXSID9045558 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045558 TK.Half.Life NA 0.9717 hours 1compartment NA NA Human Human +DTXSID9045558 Css NA 0.3204 mg/L 3compartmentss NA 50% Human Human +DTXSID9045558 Css NA 1.874 mg/L 3compartmentss NA 95% Human Human +DTXSID9045558 Css NA 0.2071 mg/L PBTK NA 50% Human Human +DTXSID9045558 Css NA 1.158 mg/L PBTK NA 95% Human Human +DTXSID9045558 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045558 Fup 0.231 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045558 Vd NA 0.316 L/kg 1compartment NA NA Rat Human +DTXSID9045558 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045558 TK.Half.Life NA 0.582 hours 1compartment NA NA Rat Human +DTXSID9045558 Css NA 0.03814 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045558 Css NA 0.1659 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045558 Css NA 0.02404 mg/L PBTK NA 50% Rat Human +DTXSID9045558 Css NA 0.09807 mg/L PBTK NA 95% Rat Human +DTXSID9045631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045631 Fup 0.00501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045631 Vd NA 2.442 L/kg 1compartment NA NA Human Human +DTXSID9045631 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID9045631 TK.Half.Life NA 56.91 hours 1compartment NA NA Human Human +DTXSID9045631 Css NA 3.408 mg/L 3compartmentss NA 50% Human Human +DTXSID9045631 Css NA 26.48 mg/L 3compartmentss NA 95% Human Human +DTXSID9045631 Css NA 2.238 mg/L PBTK NA 50% Human Human +DTXSID9045631 Css NA 16.74 mg/L PBTK NA 95% Human Human +DTXSID9045631 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045631 Fup 0.00501 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045631 Vd NA 1.816 L/kg 1compartment NA NA Rat Human +DTXSID9045631 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID9045631 TK.Half.Life NA 14.4 hours 1compartment NA NA Rat Human +DTXSID9045631 Css NA 0.4439 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045631 Css NA 2.877 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045631 Css NA 0.2844 mg/L PBTK NA 50% Rat Human +DTXSID9045631 Css NA 1.795 mg/L PBTK NA 95% Rat Human +DTXSID9045633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045633 Fup 0.0758 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045633 Vd NA 2.642 L/kg 1compartment NA NA Human Human +DTXSID9045633 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9045633 TK.Half.Life NA 16.21 hours 1compartment NA NA Human Human +DTXSID9045633 Css NA 0.7231 mg/L 3compartmentss NA 50% Human Human +DTXSID9045633 Css NA 4.592 mg/L 3compartmentss NA 95% Human Human +DTXSID9045633 Css NA 0.4924 mg/L PBTK NA 50% Human Human +DTXSID9045633 Css NA 3.071 mg/L PBTK NA 95% Human Human +DTXSID9045633 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045633 Fup 0.0758 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045633 Vd NA 1.985 L/kg 1compartment NA NA Rat Human DTXSID9045633 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045633 TK.Half.Life NA 1.698 hours 1compartment NA NA Rat Human -DTXSID9045633 Css NA 0.1327 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045633 Css NA 0.7496 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045633 Css NA 0.08656 mg/L PBTK NA 50% Rat Human -DTXSID9045633 Css NA 0.4725 mg/L PBTK NA 95% Rat Human -DTXSID9045635 Clint NA 6.209 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045635 Fup NA 0.1011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045635 Vd NA 3.352 L/kg 1compartment NA NA Human Human -DTXSID9045635 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9045635 TK.Half.Life NA 29.56 hours 1compartment NA NA Human Human -DTXSID9045635 Css NA 0.9815 mg/L 3compartmentss NA 50% Human Human -DTXSID9045635 Css NA 5.978 mg/L 3compartmentss NA 95% Human Human -DTXSID9045635 Css NA 0.7624 mg/L PBTK NA 50% Human Human -DTXSID9045635 Css NA 4.353 mg/L PBTK NA 95% Human Human -DTXSID9045635 Clint NA 6.209 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045635 Fup NA 0.1011 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045635 Vd NA 2.734 L/kg 1compartment NA NA Rat Human -DTXSID9045635 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9045635 TK.Half.Life NA 6.776 hours 1compartment NA NA Rat Human -DTXSID9045635 Css NA 0.5242 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045635 Css NA 2.522 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045635 Css NA 0.396 mg/L PBTK NA 50% Rat Human -DTXSID9045635 Css NA 1.803 mg/L PBTK NA 95% Rat Human -DTXSID9045637 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045637 Fup NA 0.6677 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045637 Vd NA 1.796 L/kg 1compartment NA NA Human Human -DTXSID9045637 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9045637 TK.Half.Life NA 21.2 hours 1compartment NA NA Human Human -DTXSID9045637 Css NA 1.133 mg/L 3compartmentss NA 50% Human Human -DTXSID9045637 Css NA 7.557 mg/L 3compartmentss NA 95% Human Human -DTXSID9045637 Css NA 1.047 mg/L PBTK NA 50% Human Human -DTXSID9045637 Css NA 5.079 mg/L PBTK NA 95% Human Human -DTXSID9045637 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045637 Fup NA 0.6677 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045637 Vd NA 1.587 L/kg 1compartment NA NA Rat Human +DTXSID9045633 TK.Half.Life NA 3.796 hours 1compartment NA NA Rat Human +DTXSID9045633 Css NA 0.09312 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045633 Css NA 0.4877 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045633 Css NA 0.0629 mg/L PBTK NA 50% Rat Human +DTXSID9045633 Css NA 0.3189 mg/L PBTK NA 95% Rat Human +DTXSID9045635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045635 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045635 Vd NA 3.546 L/kg 1compartment NA NA Human Human +DTXSID9045635 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045635 TK.Half.Life NA 10.28 hours 1compartment NA NA Human Human +DTXSID9045635 Css NA 0.2293 mg/L 3compartmentss NA 50% Human Human +DTXSID9045635 Css NA 1.62 mg/L 3compartmentss NA 95% Human Human +DTXSID9045635 Css NA 0.185 mg/L PBTK NA 50% Human Human +DTXSID9045635 Css NA 1.24 mg/L PBTK NA 95% Human Human +DTXSID9045635 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045635 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045635 Vd NA 2.893 L/kg 1compartment NA NA Rat Human +DTXSID9045635 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045635 TK.Half.Life NA 2.354 hours 1compartment NA NA Rat Human +DTXSID9045635 Css NA 0.02919 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045635 Css NA 0.1604 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045635 Css NA 0.02384 mg/L PBTK NA 50% Rat Human +DTXSID9045635 Css NA 0.125 mg/L PBTK NA 95% Rat Human +DTXSID9045637 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045637 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045637 Vd NA 2.656 L/kg 1compartment NA NA Human Human +DTXSID9045637 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045637 TK.Half.Life NA 8.099 hours 1compartment NA NA Human Human +DTXSID9045637 Css NA 0.1372 mg/L 3compartmentss NA 50% Human Human +DTXSID9045637 Css NA 1.016 mg/L 3compartmentss NA 95% Human Human +DTXSID9045637 Css NA 0.09986 mg/L PBTK NA 50% Human Human +DTXSID9045637 Css NA 0.7054 mg/L PBTK NA 95% Human Human +DTXSID9045637 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045637 Fup 0.19 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045637 Vd NA 2.035 L/kg 1compartment NA NA Rat Human DTXSID9045637 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045637 TK.Half.Life NA 5.514 hours 1compartment NA NA Rat Human -DTXSID9045637 Css NA 0.2994 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045637 Css NA 1.866 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045637 Css NA 0.2686 mg/L PBTK NA 50% Rat Human -DTXSID9045637 Css NA 1.162 mg/L PBTK NA 95% Rat Human -DTXSID9045639 Clint NA 3.767 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045639 Fup NA 0.1292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045639 Vd NA 0.2948 L/kg 1compartment NA NA Human Human +DTXSID9045637 TK.Half.Life NA 2.116 hours 1compartment NA NA Rat Human +DTXSID9045637 Css NA 0.00143 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045637 Css NA 0.008982 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045637 Css NA 0.001006 mg/L PBTK NA 50% Rat Human +DTXSID9045637 Css NA 0.005997 mg/L PBTK NA 95% Rat Human +DTXSID9045639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045639 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045639 Vd NA 0.4069 L/kg 1compartment NA NA Human Human DTXSID9045639 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045639 TK.Half.Life NA 2.235 hours 1compartment NA NA Human Human -DTXSID9045639 Css NA 1.1 mg/L 3compartmentss NA 50% Human Human -DTXSID9045639 Css NA 7.088 mg/L 3compartmentss NA 95% Human Human -DTXSID9045639 Css NA 0.6882 mg/L PBTK NA 50% Human Human -DTXSID9045639 Css NA 4.218 mg/L PBTK NA 95% Human Human -DTXSID9045639 Clint NA 3.767 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045639 Fup NA 0.1292 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045639 Vd NA 0.2921 L/kg 1compartment NA NA Rat Human +DTXSID9045639 TK.Half.Life NA 1.124 hours 1compartment NA NA Human Human +DTXSID9045639 Css NA 0.2542 mg/L 3compartmentss NA 50% Human Human +DTXSID9045639 Css NA 1.534 mg/L 3compartmentss NA 95% Human Human +DTXSID9045639 Css NA 0.1755 mg/L PBTK NA 50% Human Human +DTXSID9045639 Css NA 0.9847 mg/L PBTK NA 95% Human Human +DTXSID9045639 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045639 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045639 Vd NA 0.4054 L/kg 1compartment NA NA Rat Human DTXSID9045639 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045639 TK.Half.Life NA 1.302 hours 1compartment NA NA Rat Human -DTXSID9045639 Css NA 0.5584 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045639 Css NA 2.626 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045639 Css NA 0.3292 mg/L PBTK NA 50% Rat Human -DTXSID9045639 Css NA 1.464 mg/L PBTK NA 95% Rat Human -DTXSID9045683 Clint NA 19.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045683 Fup NA 0.3006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045683 Vd NA 2.583 L/kg 1compartment NA NA Human Human +DTXSID9045639 TK.Half.Life NA 0.6442 hours 1compartment NA NA Rat Human +DTXSID9045639 Css NA 0.03038 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045639 Css NA 0.136 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045639 Css NA 0.02065 mg/L PBTK NA 50% Rat Human +DTXSID9045639 Css NA 0.08528 mg/L PBTK NA 95% Rat Human +DTXSID9045683 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045683 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045683 Vd NA 1.498 L/kg 1compartment NA NA Human Human DTXSID9045683 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045683 TK.Half.Life NA 2.88 hours 1compartment NA NA Human Human -DTXSID9045683 Css NA 0.05418 mg/L 3compartmentss NA 50% Human Human -DTXSID9045683 Css NA 0.4245 mg/L 3compartmentss NA 95% Human Human -DTXSID9045683 Css NA 0.05472 mg/L PBTK NA 50% Human Human -DTXSID9045683 Css NA 0.3496 mg/L PBTK NA 95% Human Human -DTXSID9045683 Clint NA 19.35 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045683 Fup NA 0.3006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045683 Vd NA 2.611 L/kg 1compartment NA NA Rat Human +DTXSID9045683 TK.Half.Life NA 1.945 hours 1compartment NA NA Human Human +DTXSID9045683 Css NA 0.06773 mg/L 3compartmentss NA 50% Human Human +DTXSID9045683 Css NA 0.5255 mg/L 3compartmentss NA 95% Human Human +DTXSID9045683 Css NA 0.05523 mg/L PBTK NA 50% Human Human +DTXSID9045683 Css NA 0.3784 mg/L PBTK NA 95% Human Human +DTXSID9045683 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045683 Fup 0.258 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045683 Vd NA 1.501 L/kg 1compartment NA NA Rat Human DTXSID9045683 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045683 TK.Half.Life NA 1.622 hours 1compartment NA NA Rat Human -DTXSID9045683 Css NA 0.02824 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045683 Css NA 0.1774 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045683 Css NA 0.02818 mg/L PBTK NA 50% Rat Human -DTXSID9045683 Css NA 0.1427 mg/L PBTK NA 95% Rat Human -DTXSID9045685 Clint NA 0.7273 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045685 Fup NA 0.1298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045685 Vd NA 0.5086 L/kg 1compartment NA NA Human Human -DTXSID9045685 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9045685 TK.Half.Life NA 11.63 hours 1compartment NA NA Human Human -DTXSID9045685 Css NA 3.142 mg/L 3compartmentss NA 50% Human Human -DTXSID9045685 Css NA 17.11 mg/L 3compartmentss NA 95% Human Human -DTXSID9045685 Css NA 2.145 mg/L PBTK NA 50% Human Human -DTXSID9045685 Css NA 10.44 mg/L PBTK NA 95% Human Human -DTXSID9045685 Clint NA 0.7273 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045685 Fup NA 0.1298 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045685 Vd NA 0.502 L/kg 1compartment NA NA Rat Human +DTXSID9045683 TK.Half.Life NA 1.075 hours 1compartment NA NA Rat Human +DTXSID9045683 Css NA 0.008514 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045683 Css NA 0.0501 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045683 Css NA 0.007033 mg/L PBTK NA 50% Rat Human +DTXSID9045683 Css NA 0.03645 mg/L PBTK NA 95% Rat Human +DTXSID9045685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045685 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045685 Vd NA 0.4694 L/kg 1compartment NA NA Human Human +DTXSID9045685 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045685 TK.Half.Life NA 1.068 hours 1compartment NA NA Human Human +DTXSID9045685 Css NA 0.1979 mg/L 3compartmentss NA 50% Human Human +DTXSID9045685 Css NA 1.641 mg/L 3compartmentss NA 95% Human Human +DTXSID9045685 Css NA 0.1315 mg/L PBTK NA 50% Human Human +DTXSID9045685 Css NA 1.041 mg/L PBTK NA 95% Human Human +DTXSID9045685 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045685 Fup 0.118 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045685 Vd NA 0.4632 L/kg 1compartment NA NA Rat Human DTXSID9045685 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045685 TK.Half.Life NA 5.407 hours 1compartment NA NA Rat Human -DTXSID9045685 Css NA 1.246 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045685 Css NA 5.567 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045685 Css NA 0.7954 mg/L PBTK NA 50% Rat Human -DTXSID9045685 Css NA 3.149 mg/L PBTK NA 95% Rat Human -DTXSID9045687 Clint NA 1.833 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9045685 TK.Half.Life NA 0.6205 hours 1compartment NA NA Rat Human +DTXSID9045685 Css NA 0.00935 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045685 Css NA 0.0908 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045685 Css NA 0.006044 mg/L PBTK NA 50% Rat Human +DTXSID9045685 Css NA 0.05462 mg/L PBTK NA 95% Rat Human +DTXSID9045687 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9045687 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9045687 Vd NA 1.226 L/kg 1compartment NA NA Human Human -DTXSID9045687 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID9045687 TK.Half.Life NA 36.16 hours 1compartment NA NA Human Human -DTXSID9045687 Css NA 4.72 mg/L 3compartmentss NA 50% Human Human -DTXSID9045687 Css NA 24.84 mg/L 3compartmentss NA 95% Human Human -DTXSID9045687 Css NA 3 mg/L PBTK NA 50% Human Human -DTXSID9045687 Css NA 14.79 mg/L PBTK NA 95% Human Human -DTXSID9045687 Clint NA 1.833 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9045687 Vd NA 1.238 L/kg 1compartment NA NA Human Human +DTXSID9045687 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9045687 TK.Half.Life NA 13.38 hours 1compartment NA NA Human Human +DTXSID9045687 Css NA 1.624 mg/L 3compartmentss NA 50% Human Human +DTXSID9045687 Css NA 11.35 mg/L 3compartmentss NA 95% Human Human +DTXSID9045687 Css NA 1.033 mg/L PBTK NA 50% Human Human +DTXSID9045687 Css NA 6.854 mg/L PBTK NA 95% Human Human +DTXSID9045687 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9045687 Fup 0.06 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9045687 Vd NA 0.9383 L/kg 1compartment NA NA Rat Human -DTXSID9045687 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9045687 TK.Half.Life NA 13.37 hours 1compartment NA NA Rat Human -DTXSID9045687 Css NA 2.178 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045687 Css NA 8.984 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045687 Css NA 1.314 mg/L PBTK NA 50% Rat Human -DTXSID9045687 Css NA 5.037 mg/L PBTK NA 95% Rat Human -DTXSID9045689 Clint NA 68.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045689 Fup NA 0.0297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045689 Vd NA 2.709 L/kg 1compartment NA NA Human Human -DTXSID9045689 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045689 TK.Half.Life NA 11.59 hours 1compartment NA NA Human Human -DTXSID9045689 Css NA 0.4992 mg/L 3compartmentss NA 50% Human Human -DTXSID9045689 Css NA 3.621 mg/L 3compartmentss NA 95% Human Human -DTXSID9045689 Css NA 0.3381 mg/L PBTK NA 50% Human Human -DTXSID9045689 Css NA 2.314 mg/L PBTK NA 95% Human Human -DTXSID9045689 Clint NA 68.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045689 Fup NA 0.0297 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045689 Vd NA 2.026 L/kg 1compartment NA NA Rat Human -DTXSID9045689 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045689 TK.Half.Life NA 2.673 hours 1compartment NA NA Rat Human -DTXSID9045689 Css NA 0.2834 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045689 Css NA 1.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045689 Css NA 0.1814 mg/L PBTK NA 50% Rat Human -DTXSID9045689 Css NA 0.9864 mg/L PBTK NA 95% Rat Human -DTXSID9045710 Clint NA 44.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045710 Fup NA 0.1691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045710 Vd NA 0.888 L/kg 1compartment NA NA Human Human +DTXSID9045687 Vd NA 0.9471 L/kg 1compartment NA NA Rat Human +DTXSID9045687 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045687 TK.Half.Life NA 5.527 hours 1compartment NA NA Rat Human +DTXSID9045687 Css NA 0.2006 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045687 Css NA 1.029 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045687 Css NA 0.1249 mg/L PBTK NA 50% Rat Human +DTXSID9045687 Css NA 0.6085 mg/L PBTK NA 95% Rat Human +DTXSID9045689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045689 Fup 0.0643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045689 Vd NA 3.042 L/kg 1compartment NA NA Human Human +DTXSID9045689 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID9045689 TK.Half.Life NA 43.9 hours 1compartment NA NA Human Human +DTXSID9045689 Css NA 1.682 mg/L 3compartmentss NA 50% Human Human +DTXSID9045689 Css NA 10.88 mg/L 3compartmentss NA 95% Human Human +DTXSID9045689 Css NA 1.17 mg/L PBTK NA 50% Human Human +DTXSID9045689 Css NA 7.341 mg/L PBTK NA 95% Human Human +DTXSID9045689 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045689 Fup 0.0643 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045689 Vd NA 2.282 L/kg 1compartment NA NA Rat Human +DTXSID9045689 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID9045689 TK.Half.Life NA 6.809 hours 1compartment NA NA Rat Human +DTXSID9045689 Css NA 0.2172 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045689 Css NA 1.219 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045689 Css NA 0.1496 mg/L PBTK NA 50% Rat Human +DTXSID9045689 Css NA 0.8272 mg/L PBTK NA 95% Rat Human +DTXSID9045710 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045710 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045710 Vd NA 1.101 L/kg 1compartment NA NA Human Human DTXSID9045710 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045710 TK.Half.Life NA 1.17 hours 1compartment NA NA Human Human -DTXSID9045710 Css NA 0.06691 mg/L 3compartmentss NA 50% Human Human -DTXSID9045710 Css NA 0.49 mg/L 3compartmentss NA 95% Human Human -DTXSID9045710 Css NA 0.04595 mg/L PBTK NA 50% Human Human -DTXSID9045710 Css NA 0.3153 mg/L PBTK NA 95% Human Human -DTXSID9045710 Clint NA 44.88 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045710 Fup NA 0.1691 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045710 Vd NA 0.7357 L/kg 1compartment NA NA Rat Human +DTXSID9045710 TK.Half.Life NA 2.977 hours 1compartment NA NA Human Human +DTXSID9045710 Css NA 0.2344 mg/L 3compartmentss NA 50% Human Human +DTXSID9045710 Css NA 1.479 mg/L 3compartmentss NA 95% Human Human +DTXSID9045710 Css NA 0.1737 mg/L PBTK NA 50% Human Human +DTXSID9045710 Css NA 1.007 mg/L PBTK NA 95% Human Human +DTXSID9045710 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045710 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045710 Vd NA 0.928 L/kg 1compartment NA NA Rat Human DTXSID9045710 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045710 TK.Half.Life NA 0.498 hours 1compartment NA NA Rat Human -DTXSID9045710 Css NA 0.03735 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045710 Css NA 0.2086 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045710 Css NA 0.02418 mg/L PBTK NA 50% Rat Human -DTXSID9045710 Css NA 0.1281 mg/L PBTK NA 95% Rat Human -DTXSID9045762 Clint NA 236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045762 Fup NA 0.0842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045762 Vd NA 2.766 L/kg 1compartment NA NA Human Human +DTXSID9045710 TK.Half.Life NA 1.356 hours 1compartment NA NA Rat Human +DTXSID9045710 Css NA 0.02796 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045710 Css NA 0.1316 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045710 Css NA 0.0207 mg/L PBTK NA 50% Rat Human +DTXSID9045710 Css NA 0.08633 mg/L PBTK NA 95% Rat Human +DTXSID9045762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045762 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045762 Vd NA 3.402 L/kg 1compartment NA NA Human Human DTXSID9045762 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045762 TK.Half.Life NA 1.815 hours 1compartment NA NA Human Human -DTXSID9045762 Css NA 0.01041 mg/L 3compartmentss NA 50% Human Human -DTXSID9045762 Css NA 0.103 mg/L 3compartmentss NA 95% Human Human -DTXSID9045762 Css NA 0.009372 mg/L PBTK NA 50% Human Human -DTXSID9045762 Css NA 0.07708 mg/L PBTK NA 95% Human Human -DTXSID9045762 Clint NA 236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045762 Fup NA 0.0842 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045762 Vd NA 2.719 L/kg 1compartment NA NA Rat Human +DTXSID9045762 TK.Half.Life NA 4.035 hours 1compartment NA NA Human Human +DTXSID9045762 Css NA 0.06808 mg/L 3compartmentss NA 50% Human Human +DTXSID9045762 Css NA 0.7046 mg/L 3compartmentss NA 95% Human Human +DTXSID9045762 Css NA 0.06912 mg/L PBTK NA 50% Human Human +DTXSID9045762 Css NA 0.5574 mg/L PBTK NA 95% Human Human +DTXSID9045762 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045762 Fup 0.116 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045762 Vd NA 3.363 L/kg 1compartment NA NA Rat Human DTXSID9045762 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045762 TK.Half.Life NA 0.8321 hours 1compartment NA NA Rat Human -DTXSID9045762 Css NA 0.00581 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045762 Css NA 0.04849 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045762 Css NA 0.005103 mg/L PBTK NA 50% Rat Human -DTXSID9045762 Css NA 0.03459 mg/L PBTK NA 95% Rat Human -DTXSID9045764 Clint NA 3.491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045764 Fup NA 0.101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045764 Vd NA 0.2996 L/kg 1compartment NA NA Human Human +DTXSID9045762 TK.Half.Life NA 2.201 hours 1compartment NA NA Rat Human +DTXSID9045762 Css NA 0.008566 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045762 Css NA 0.07289 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045762 Css NA 0.00891 mg/L PBTK NA 50% Rat Human +DTXSID9045762 Css NA 0.05774 mg/L PBTK NA 95% Rat Human +DTXSID9045764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045764 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045764 Vd NA 0.3605 L/kg 1compartment NA NA Human Human DTXSID9045764 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045764 TK.Half.Life NA 3.018 hours 1compartment NA NA Human Human -DTXSID9045764 Css NA 1.584 mg/L 3compartmentss NA 50% Human Human -DTXSID9045764 Css NA 9.571 mg/L 3compartmentss NA 95% Human Human -DTXSID9045764 Css NA 0.9732 mg/L PBTK NA 50% Human Human -DTXSID9045764 Css NA 5.681 mg/L PBTK NA 95% Human Human -DTXSID9045764 Clint NA 3.491 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045764 Fup NA 0.101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045764 Vd NA 0.2835 L/kg 1compartment NA NA Rat Human +DTXSID9045764 TK.Half.Life NA 0.5869 hours 1compartment NA NA Human Human +DTXSID9045764 Css NA 0.1037 mg/L 3compartmentss NA 50% Human Human +DTXSID9045764 Css NA 0.7414 mg/L 3compartmentss NA 95% Human Human +DTXSID9045764 Css NA 0.06783 mg/L PBTK NA 50% Human Human +DTXSID9045764 Css NA 0.4633 mg/L PBTK NA 95% Human Human +DTXSID9045764 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045764 Fup 0.213 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045764 Vd NA 0.3499 L/kg 1compartment NA NA Rat Human DTXSID9045764 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045764 TK.Half.Life NA 1.68 hours 1compartment NA NA Rat Human -DTXSID9045764 Css NA 0.7996 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045764 Css NA 3.687 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045764 Css NA 0.4606 mg/L PBTK NA 50% Rat Human -DTXSID9045764 Css NA 2.026 mg/L PBTK NA 95% Rat Human -DTXSID9045766 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045766 Fup NA 0.3318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045766 Vd NA 3.138 L/kg 1compartment NA NA Human Human -DTXSID9045766 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID9045766 TK.Half.Life NA 74260 hours 1compartment NA NA Human Human -DTXSID9045766 Css NA 2671 mg/L 3compartmentss NA 50% Human Human -DTXSID9045766 Css NA 7335 mg/L 3compartmentss NA 95% Human Human -DTXSID9045766 Css NA 1867 mg/L PBTK NA 50% Human Human -DTXSID9045766 Css NA 4795 mg/L PBTK NA 95% Human Human -DTXSID9045766 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045766 Fup NA 0.3318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045766 Vd NA 2.351 L/kg 1compartment NA NA Rat Human -DTXSID9045766 Days.Css NA 3276 Days PBTK NA NA Rat Human -DTXSID9045766 TK.Half.Life NA 4530 hours 1compartment NA NA Rat Human -DTXSID9045766 Css NA 723.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045766 Css NA 1585 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045766 Css NA 483.4 mg/L PBTK NA 50% Rat Human -DTXSID9045766 Css NA 958.3 mg/L PBTK NA 95% Rat Human -DTXSID9045768 Clint NA 14.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045768 Fup NA 0.1088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045768 Vd NA 3.915 L/kg 1compartment NA NA Human Human +DTXSID9045764 TK.Half.Life NA 0.3121 hours 1compartment NA NA Rat Human +DTXSID9045764 Css NA 0.01338 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045764 Css NA 0.07187 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045764 Css NA 0.008522 mg/L PBTK NA 50% Rat Human +DTXSID9045764 Css NA 0.04418 mg/L PBTK NA 95% Rat Human +DTXSID9045768 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045768 Fup 0.0516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045768 Vd NA 3.267 L/kg 1compartment NA NA Human Human DTXSID9045768 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045768 TK.Half.Life NA 6.973 hours 1compartment NA NA Human Human -DTXSID9045768 Css NA 0.1278 mg/L 3compartmentss NA 50% Human Human -DTXSID9045768 Css NA 0.9059 mg/L 3compartmentss NA 95% Human Human -DTXSID9045768 Css NA 0.115 mg/L PBTK NA 50% Human Human -DTXSID9045768 Css NA 0.734 mg/L PBTK NA 95% Human Human -DTXSID9045768 Clint NA 14.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045768 Fup NA 0.1088 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045768 Vd NA 3.432 L/kg 1compartment NA NA Rat Human +DTXSID9045768 TK.Half.Life NA 5.631 hours 1compartment NA NA Human Human +DTXSID9045768 Css NA 0.1289 mg/L 3compartmentss NA 50% Human Human +DTXSID9045768 Css NA 1.021 mg/L 3compartmentss NA 95% Human Human +DTXSID9045768 Css NA 0.1045 mg/L PBTK NA 50% Human Human +DTXSID9045768 Css NA 0.7452 mg/L PBTK NA 95% Human Human +DTXSID9045768 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045768 Fup 0.0516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045768 Vd NA 2.811 L/kg 1compartment NA NA Rat Human DTXSID9045768 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045768 TK.Half.Life NA 2.219 hours 1compartment NA NA Rat Human -DTXSID9045768 Css NA 0.06912 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045768 Css NA 0.4059 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045768 Css NA 0.06172 mg/L PBTK NA 50% Rat Human -DTXSID9045768 Css NA 0.3237 mg/L PBTK NA 95% Rat Human -DTXSID9045843 Clint NA 40.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045843 Fup NA 0.7913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045843 Vd NA 1.048 L/kg 1compartment NA NA Human Human +DTXSID9045768 TK.Half.Life NA 1.985 hours 1compartment NA NA Rat Human +DTXSID9045768 Css NA 0.01632 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045768 Css NA 0.1107 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045768 Css NA 0.01335 mg/L PBTK NA 50% Rat Human +DTXSID9045768 Css NA 0.08406 mg/L PBTK NA 95% Rat Human +DTXSID9045843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045843 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045843 Vd NA 0.7654 L/kg 1compartment NA NA Human Human DTXSID9045843 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045843 TK.Half.Life NA 0.7046 hours 1compartment NA NA Human Human -DTXSID9045843 Css NA 0.01539 mg/L 3compartmentss NA 50% Human Human -DTXSID9045843 Css NA 0.1654 mg/L 3compartmentss NA 95% Human Human -DTXSID9045843 Css NA 0.0132 mg/L PBTK NA 50% Human Human -DTXSID9045843 Css NA 0.1201 mg/L PBTK NA 95% Human Human -DTXSID9045843 Clint NA 40.36 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045843 Fup NA 0.7913 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045843 Vd NA 1.008 L/kg 1compartment NA NA Rat Human +DTXSID9045843 TK.Half.Life NA 0.7853 hours 1compartment NA NA Human Human +DTXSID9045843 Css NA 0.04093 mg/L 3compartmentss NA 50% Human Human +DTXSID9045843 Css NA 0.3552 mg/L 3compartmentss NA 95% Human Human +DTXSID9045843 Css NA 0.03164 mg/L PBTK NA 50% Human Human +DTXSID9045843 Css NA 0.2466 mg/L PBTK NA 95% Human Human +DTXSID9045843 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045843 Fup 0.468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045843 Vd NA 0.7338 L/kg 1compartment NA NA Rat Human DTXSID9045843 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045843 TK.Half.Life NA 0.3149 hours 1compartment NA NA Rat Human -DTXSID9045843 Css NA 0.007739 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045843 Css NA 0.07423 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045843 Css NA 0.006622 mg/L PBTK NA 50% Rat Human -DTXSID9045843 Css NA 0.05113 mg/L PBTK NA 95% Rat Human -DTXSID9045845 Clint NA 1.956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045845 Fup NA 0.5789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045845 Vd NA 3.098 L/kg 1compartment NA NA Human Human -DTXSID9045845 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045845 TK.Half.Life NA 8.221 hours 1compartment NA NA Human Human -DTXSID9045845 Css NA 0.1784 mg/L 3compartmentss NA 50% Human Human -DTXSID9045845 Css NA 1.805 mg/L 3compartmentss NA 95% Human Human -DTXSID9045845 Css NA 0.2316 mg/L PBTK NA 50% Human Human -DTXSID9045845 Css NA 1.417 mg/L PBTK NA 95% Human Human -DTXSID9045845 Clint NA 1.956 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045845 Fup NA 0.5789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045845 Vd NA 3.073 L/kg 1compartment NA NA Rat Human -DTXSID9045845 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045845 TK.Half.Life NA 4.446 hours 1compartment NA NA Rat Human -DTXSID9045845 Css NA 0.0738 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045845 Css NA 0.7334 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045845 Css NA 0.09651 mg/L PBTK NA 50% Rat Human -DTXSID9045845 Css NA 0.5202 mg/L PBTK NA 95% Rat Human -DTXSID9045847 Clint NA 6.335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045847 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045847 Vd NA 0.2897 L/kg 1compartment NA NA Human Human -DTXSID9045847 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045847 TK.Half.Life NA 0.8827 hours 1compartment NA NA Human Human -DTXSID9045847 Css NA 0.3088 mg/L 3compartmentss NA 50% Human Human -DTXSID9045847 Css NA 1.869 mg/L 3compartmentss NA 95% Human Human -DTXSID9045847 Css NA 0.1984 mg/L PBTK NA 50% Human Human -DTXSID9045847 Css NA 1.125 mg/L PBTK NA 95% Human Human -DTXSID9045847 Clint NA 6.335 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045847 Fup NA 0.2381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045847 Vd NA 0.2944 L/kg 1compartment NA NA Rat Human -DTXSID9045847 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045847 TK.Half.Life NA 0.5184 hours 1compartment NA NA Rat Human -DTXSID9045847 Css NA 0.1623 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045847 Css NA 0.6884 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045847 Css NA 0.0983 mg/L PBTK NA 50% Rat Human -DTXSID9045847 Css NA 0.3951 mg/L PBTK NA 95% Rat Human -DTXSID9045849 Clint NA 0.1653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045849 Fup NA 0.0266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045849 Vd NA 0.4369 L/kg 1compartment NA NA Human Human -DTXSID9045849 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID9045849 TK.Half.Life NA 84.05 hours 1compartment NA NA Human Human -DTXSID9045849 Css NA 32.08 mg/L 3compartmentss NA 50% Human Human -DTXSID9045849 Css NA 194.3 mg/L 3compartmentss NA 95% Human Human -DTXSID9045849 Css NA 19.2 mg/L PBTK NA 50% Human Human -DTXSID9045849 Css NA 112.6 mg/L PBTK NA 95% Human Human -DTXSID9045849 Clint NA 0.1653 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045849 Fup NA 0.0266 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045849 Vd NA 0.3495 L/kg 1compartment NA NA Rat Human -DTXSID9045849 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9045849 TK.Half.Life NA 25.47 hours 1compartment NA NA Rat Human -DTXSID9045849 Css NA 10.54 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045849 Css NA 58.26 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045849 Css NA 5.857 mg/L PBTK NA 50% Rat Human -DTXSID9045849 Css NA 31.64 mg/L PBTK NA 95% Rat Human -DTXSID9045891 Clint NA 0.1839 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045891 Fup NA 0.6979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045891 Vd NA 2.099 L/kg 1compartment NA NA Human Human -DTXSID9045891 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9045891 TK.Half.Life NA 14.94 hours 1compartment NA NA Human Human -DTXSID9045891 Css NA 0.631 mg/L 3compartmentss NA 50% Human Human -DTXSID9045891 Css NA 4.749 mg/L 3compartmentss NA 95% Human Human -DTXSID9045891 Css NA 0.6632 mg/L PBTK NA 50% Human Human -DTXSID9045891 Css NA 3.301 mg/L PBTK NA 95% Human Human -DTXSID9045891 Clint NA 0.1839 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045891 Fup NA 0.6979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045891 Vd NA 2.099 L/kg 1compartment NA NA Rat Human +DTXSID9045843 TK.Half.Life NA 0.3813 hours 1compartment NA NA Rat Human +DTXSID9045843 Css NA 0.00499 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045843 Css NA 0.03608 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045843 Css NA 0.003904 mg/L PBTK NA 50% Rat Human +DTXSID9045843 Css NA 0.02416 mg/L PBTK NA 95% Rat Human +DTXSID9045849 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045849 Fup 0.0363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045849 Vd NA 0.8136 L/kg 1compartment NA NA Human Human +DTXSID9045849 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9045849 TK.Half.Life NA 12.98 hours 1compartment NA NA Human Human +DTXSID9045849 Css NA 2.748 mg/L 3compartmentss NA 50% Human Human +DTXSID9045849 Css NA 18.95 mg/L 3compartmentss NA 95% Human Human +DTXSID9045849 Css NA 1.681 mg/L PBTK NA 50% Human Human +DTXSID9045849 Css NA 11.2 mg/L PBTK NA 95% Human Human +DTXSID9045849 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045849 Fup 0.0363 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045849 Vd NA 0.6179 L/kg 1compartment NA NA Rat Human +DTXSID9045849 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045849 TK.Half.Life NA 5.805 hours 1compartment NA NA Rat Human +DTXSID9045849 Css NA 0.3453 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045849 Css NA 1.804 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045849 Css NA 0.2038 mg/L PBTK NA 50% Rat Human +DTXSID9045849 Css NA 1.031 mg/L PBTK NA 95% Rat Human +DTXSID9045891 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045891 Fup 0.624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045891 Vd NA 1.809 L/kg 1compartment NA NA Human Human +DTXSID9045891 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9045891 TK.Half.Life NA 18.76 hours 1compartment NA NA Human Human +DTXSID9045891 Css NA 0.8181 mg/L 3compartmentss NA 50% Human Human +DTXSID9045891 Css NA 6.259 mg/L 3compartmentss NA 95% Human Human +DTXSID9045891 Css NA 0.8134 mg/L PBTK NA 50% Human Human +DTXSID9045891 Css NA 4.253 mg/L PBTK NA 95% Human Human +DTXSID9045891 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045891 Fup 0.624 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045891 Vd NA 1.807 L/kg 1compartment NA NA Rat Human DTXSID9045891 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045891 TK.Half.Life NA 5.776 hours 1compartment NA NA Rat Human -DTXSID9045891 Css NA 0.1842 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045891 Css NA 1.452 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045891 Css NA 0.1914 mg/L PBTK NA 50% Rat Human -DTXSID9045891 Css NA 0.9354 mg/L PBTK NA 95% Rat Human -DTXSID9045895 Clint NA 0.7111 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045895 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045895 Vd NA 0.49 L/kg 1compartment NA NA Human Human -DTXSID9045895 Days.Css NA 30 Days PBTK NA NA Human Human -DTXSID9045895 TK.Half.Life NA 136.1 hours 1compartment NA NA Human Human -DTXSID9045895 Css NA 46.16 mg/L 3compartmentss NA 50% Human Human -DTXSID9045895 Css NA 309 mg/L 3compartmentss NA 95% Human Human -DTXSID9045895 Css NA 28.4 mg/L PBTK NA 50% Human Human -DTXSID9045895 Css NA 183.3 mg/L PBTK NA 95% Human Human -DTXSID9045895 Clint NA 0.7111 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045895 Fup NA 0.0102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045895 Vd NA 0.421 L/kg 1compartment NA NA Rat Human -DTXSID9045895 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID9045895 TK.Half.Life NA 55.54 hours 1compartment NA NA Rat Human -DTXSID9045895 Css NA 18.66 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045895 Css NA 113.6 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045895 Css NA 10.75 mg/L PBTK NA 50% Rat Human -DTXSID9045895 Css NA 61.99 mg/L PBTK NA 95% Rat Human +DTXSID9045891 TK.Half.Life NA 6.383 hours 1compartment NA NA Rat Human +DTXSID9045891 Css NA 0.01554 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045891 Css NA 0.1578 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045891 Css NA 0.01484 mg/L PBTK NA 50% Rat Human +DTXSID9045891 Css NA 0.1068 mg/L PBTK NA 95% Rat Human +DTXSID9045895 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045895 Fup 0.0339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045895 Vd NA 0.7588 L/kg 1compartment NA NA Human Human +DTXSID9045895 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045895 TK.Half.Life NA 4.319 hours 1compartment NA NA Human Human +DTXSID9045895 Css NA 0.7318 mg/L 3compartmentss NA 50% Human Human +DTXSID9045895 Css NA 6.199 mg/L 3compartmentss NA 95% Human Human +DTXSID9045895 Css NA 0.4908 mg/L PBTK NA 50% Human Human +DTXSID9045895 Css NA 3.887 mg/L PBTK NA 95% Human Human +DTXSID9045895 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045895 Fup 0.0339 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045895 Vd NA 0.6735 L/kg 1compartment NA NA Rat Human +DTXSID9045895 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045895 TK.Half.Life NA 2.418 hours 1compartment NA NA Rat Human +DTXSID9045895 Css NA 0.0352 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045895 Css NA 0.3329 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045895 Css NA 0.02288 mg/L PBTK NA 50% Rat Human +DTXSID9045895 Css NA 0.2043 mg/L PBTK NA 95% Rat Human DTXSID9045897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9045897 Fup NA 0.7904 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045897 Vd NA 0.4364 L/kg 1compartment NA NA Human Human +DTXSID9045897 Vd NA 0.4544 L/kg 1compartment NA NA Human Human DTXSID9045897 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045897 TK.Half.Life NA 3.573 hours 1compartment NA NA Human Human -DTXSID9045897 Css NA 1.136 mg/L 3compartmentss NA 50% Human Human -DTXSID9045897 Css NA 6.144 mg/L 3compartmentss NA 95% Human Human -DTXSID9045897 Css NA 0.8268 mg/L PBTK NA 50% Human Human -DTXSID9045897 Css NA 3.793 mg/L PBTK NA 95% Human Human +DTXSID9045897 TK.Half.Life NA 3.719 hours 1compartment NA NA Human Human +DTXSID9045897 Css NA 0.9504 mg/L 3compartmentss NA 50% Human Human +DTXSID9045897 Css NA 5.603 mg/L 3compartmentss NA 95% Human Human +DTXSID9045897 Css NA 0.6984 mg/L PBTK NA 50% Human Human +DTXSID9045897 Css NA 3.464 mg/L PBTK NA 95% Human Human DTXSID9045897 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9045897 Fup NA 0.7904 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045897 Vd NA 0.4591 L/kg 1compartment NA NA Rat Human +DTXSID9045897 Vd NA 0.4748 L/kg 1compartment NA NA Rat Human DTXSID9045897 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045897 TK.Half.Life NA 1.281 hours 1compartment NA NA Rat Human -DTXSID9045897 Css NA 0.2892 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045897 Css NA 1.626 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045897 Css NA 0.2027 mg/L PBTK NA 50% Rat Human -DTXSID9045897 Css NA 0.9348 mg/L PBTK NA 95% Rat Human -DTXSID9045899 Clint NA 16.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045899 Fup NA 0.099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045899 Vd NA 2.401 L/kg 1compartment NA NA Human Human +DTXSID9045897 TK.Half.Life NA 1.324 hours 1compartment NA NA Rat Human +DTXSID9045897 Css NA 0.01758 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045897 Css NA 0.1282 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045897 Css NA 0.01238 mg/L PBTK NA 50% Rat Human +DTXSID9045897 Css NA 0.0783 mg/L PBTK NA 95% Rat Human +DTXSID9045899 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045899 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045899 Vd NA 2.224 L/kg 1compartment NA NA Human Human DTXSID9045899 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045899 TK.Half.Life NA 12.53 hours 1compartment NA NA Human Human -DTXSID9045899 Css NA 0.6342 mg/L 3compartmentss NA 50% Human Human -DTXSID9045899 Css NA 3.965 mg/L 3compartmentss NA 95% Human Human -DTXSID9045899 Css NA 0.4362 mg/L PBTK NA 50% Human Human -DTXSID9045899 Css NA 2.635 mg/L PBTK NA 95% Human Human -DTXSID9045899 Clint NA 16.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045899 Fup NA 0.099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045899 Vd NA 1.811 L/kg 1compartment NA NA Rat Human +DTXSID9045899 TK.Half.Life NA 7.02 hours 1compartment NA NA Human Human +DTXSID9045899 Css NA 0.3251 mg/L 3compartmentss NA 50% Human Human +DTXSID9045899 Css NA 2.298 mg/L 3compartmentss NA 95% Human Human +DTXSID9045899 Css NA 0.2244 mg/L PBTK NA 50% Human Human +DTXSID9045899 Css NA 1.492 mg/L PBTK NA 95% Human Human +DTXSID9045899 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045899 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045899 Vd NA 1.686 L/kg 1compartment NA NA Rat Human DTXSID9045899 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045899 TK.Half.Life NA 3.43 hours 1compartment NA NA Rat Human -DTXSID9045899 Css NA 0.3497 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045899 Css NA 1.69 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045899 Css NA 0.2275 mg/L PBTK NA 50% Rat Human -DTXSID9045899 Css NA 1.054 mg/L PBTK NA 95% Rat Human -DTXSID9045922 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045922 Fup NA 0.0817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045922 Vd NA 0.2323 L/kg 1compartment NA NA Human Human -DTXSID9045922 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9045922 TK.Half.Life NA 18.4 hours 1compartment NA NA Human Human -DTXSID9045922 Css NA 12.85 mg/L 3compartmentss NA 50% Human Human -DTXSID9045922 Css NA 58.33 mg/L 3compartmentss NA 95% Human Human -DTXSID9045922 Css NA 7.768 mg/L PBTK NA 50% Human Human -DTXSID9045922 Css NA 33.91 mg/L PBTK NA 95% Human Human -DTXSID9045922 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045922 Fup NA 0.0817 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045922 Vd NA 0.2306 L/kg 1compartment NA NA Rat Human +DTXSID9045899 TK.Half.Life NA 2.149 hours 1compartment NA NA Rat Human +DTXSID9045899 Css NA 0.04236 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045899 Css NA 0.2269 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045899 Css NA 0.02889 mg/L PBTK NA 50% Rat Human +DTXSID9045899 Css NA 0.1469 mg/L PBTK NA 95% Rat Human +DTXSID9045922 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045922 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045922 Vd NA 0.4808 L/kg 1compartment NA NA Human Human +DTXSID9045922 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045922 TK.Half.Life NA 0.8645 hours 1compartment NA NA Human Human +DTXSID9045922 Css NA 0.1083 mg/L 3compartmentss NA 50% Human Human +DTXSID9045922 Css NA 0.7826 mg/L 3compartmentss NA 95% Human Human +DTXSID9045922 Css NA 0.07591 mg/L PBTK NA 50% Human Human +DTXSID9045922 Css NA 0.516 mg/L PBTK NA 95% Human Human +DTXSID9045922 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045922 Fup 0.168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045922 Vd NA 0.4727 L/kg 1compartment NA NA Rat Human DTXSID9045922 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045922 TK.Half.Life NA 6.222 hours 1compartment NA NA Rat Human -DTXSID9045922 Css NA 3.628 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045922 Css NA 13.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045922 Css NA 2.046 mg/L PBTK NA 50% Rat Human -DTXSID9045922 Css NA 7.595 mg/L PBTK NA 95% Rat Human -DTXSID9045924 Clint NA 2.696 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045924 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045924 Vd NA 0.2867 L/kg 1compartment NA NA Human Human -DTXSID9045924 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9045924 TK.Half.Life NA 25.45 hours 1compartment NA NA Human Human -DTXSID9045924 Css NA 16.28 mg/L 3compartmentss NA 50% Human Human -DTXSID9045924 Css NA 124.9 mg/L 3compartmentss NA 95% Human Human -DTXSID9045924 Css NA 9.567 mg/L PBTK NA 50% Human Human -DTXSID9045924 Css NA 72.68 mg/L PBTK NA 95% Human Human -DTXSID9045924 Clint NA 2.696 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045924 Fup NA 0.0128 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045924 Vd NA 0.2412 L/kg 1compartment NA NA Rat Human -DTXSID9045924 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9045924 TK.Half.Life NA 12.58 hours 1compartment NA NA Rat Human -DTXSID9045924 Css NA 7.941 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045924 Css NA 49.29 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045924 Css NA 4.352 mg/L PBTK NA 50% Rat Human -DTXSID9045924 Css NA 26.7 mg/L PBTK NA 95% Rat Human -DTXSID9045928 Clint NA 3.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045928 Fup NA 0.0391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045928 Vd NA 0.2219 L/kg 1compartment NA NA Human Human +DTXSID9045922 TK.Half.Life NA 0.4837 hours 1compartment NA NA Rat Human +DTXSID9045922 Css NA 0.005076 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045922 Css NA 0.0415 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045922 Css NA 0.003508 mg/L PBTK NA 50% Rat Human +DTXSID9045922 Css NA 0.02635 mg/L PBTK NA 95% Rat Human +DTXSID9045924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045924 Fup 0.0588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045924 Vd NA 0.7156 L/kg 1compartment NA NA Human Human +DTXSID9045924 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045924 TK.Half.Life NA 2.689 hours 1compartment NA NA Human Human +DTXSID9045924 Css NA 0.4294 mg/L 3compartmentss NA 50% Human Human +DTXSID9045924 Css NA 3.473 mg/L 3compartmentss NA 95% Human Human +DTXSID9045924 Css NA 0.2694 mg/L PBTK NA 50% Human Human +DTXSID9045924 Css NA 2.071 mg/L PBTK NA 95% Human Human +DTXSID9045924 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045924 Fup 0.0588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045924 Vd NA 0.5997 L/kg 1compartment NA NA Rat Human +DTXSID9045924 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045924 TK.Half.Life NA 1.359 hours 1compartment NA NA Rat Human +DTXSID9045924 Css NA 0.02097 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045924 Css NA 0.1845 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045924 Css NA 0.01264 mg/L PBTK NA 50% Rat Human +DTXSID9045924 Css NA 0.1072 mg/L PBTK NA 95% Rat Human +DTXSID9045928 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045928 Fup 0.0723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045928 Vd NA 1.114 L/kg 1compartment NA NA Human Human DTXSID9045928 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045928 TK.Half.Life NA 5.407 hours 1compartment NA NA Human Human -DTXSID9045928 Css NA 4.476 mg/L 3compartmentss NA 50% Human Human -DTXSID9045928 Css NA 32.6 mg/L 3compartmentss NA 95% Human Human -DTXSID9045928 Css NA 2.652 mg/L PBTK NA 50% Human Human -DTXSID9045928 Css NA 19.09 mg/L PBTK NA 95% Human Human -DTXSID9045928 Clint NA 3.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045928 Fup NA 0.0391 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045928 Vd NA 0.2179 L/kg 1compartment NA NA Rat Human +DTXSID9045928 TK.Half.Life NA 10.03 hours 1compartment NA NA Human Human +DTXSID9045928 Css NA 1.174 mg/L 3compartmentss NA 50% Human Human +DTXSID9045928 Css NA 7.89 mg/L 3compartmentss NA 95% Human Human +DTXSID9045928 Css NA 0.7533 mg/L PBTK NA 50% Human Human +DTXSID9045928 Css NA 4.834 mg/L PBTK NA 95% Human Human +DTXSID9045928 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045928 Fup 0.0723 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045928 Vd NA 0.8566 L/kg 1compartment NA NA Rat Human DTXSID9045928 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045928 TK.Half.Life NA 3.196 hours 1compartment NA NA Rat Human -DTXSID9045928 Css NA 2.232 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045928 Css NA 13.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045928 Css NA 1.244 mg/L PBTK NA 50% Rat Human -DTXSID9045928 Css NA 7.101 mg/L PBTK NA 95% Rat Human -DTXSID9045976 Clint NA 0.4406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045976 Fup NA 0.1666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045976 Vd NA 0.3488 L/kg 1compartment NA NA Human Human +DTXSID9045928 TK.Half.Life NA 4.263 hours 1compartment NA NA Rat Human +DTXSID9045928 Css NA 0.05321 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045928 Css NA 0.4035 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045928 Css NA 0.03279 mg/L PBTK NA 50% Rat Human +DTXSID9045928 Css NA 0.2393 mg/L PBTK NA 95% Rat Human +DTXSID9045976 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045976 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045976 Vd NA 0.4325 L/kg 1compartment NA NA Human Human DTXSID9045976 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9045976 TK.Half.Life NA 7.845 hours 1compartment NA NA Human Human -DTXSID9045976 Css NA 2.84 mg/L 3compartmentss NA 50% Human Human -DTXSID9045976 Css NA 10.94 mg/L 3compartmentss NA 95% Human Human -DTXSID9045976 Css NA 1.847 mg/L PBTK NA 50% Human Human -DTXSID9045976 Css NA 6.65 mg/L PBTK NA 95% Human Human -DTXSID9045976 Clint NA 0.4406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045976 Fup NA 0.1666 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045976 Vd NA 0.3493 L/kg 1compartment NA NA Rat Human +DTXSID9045976 TK.Half.Life NA 1.241 hours 1compartment NA NA Human Human +DTXSID9045976 Css NA 0.2664 mg/L 3compartmentss NA 50% Human Human +DTXSID9045976 Css NA 1.575 mg/L 3compartmentss NA 95% Human Human +DTXSID9045976 Css NA 0.185 mg/L PBTK NA 50% Human Human +DTXSID9045976 Css NA 1.01 mg/L PBTK NA 95% Human Human +DTXSID9045976 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045976 Fup 0.256 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045976 Vd NA 0.4343 L/kg 1compartment NA NA Rat Human DTXSID9045976 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9045976 TK.Half.Life NA 3.411 hours 1compartment NA NA Rat Human -DTXSID9045976 Css NA 1.024 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045976 Css NA 3.379 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045976 Css NA 0.6304 mg/L PBTK NA 50% Rat Human -DTXSID9045976 Css NA 1.91 mg/L PBTK NA 95% Rat Human -DTXSID9045978 Clint NA 38.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045978 Fup NA 0.0621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9045978 Vd NA 77.95 L/kg 1compartment NA NA Human Human -DTXSID9045978 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID9045978 TK.Half.Life NA 88.92 hours 1compartment NA NA Human Human -DTXSID9045978 Css NA 0.01064 mg/L 3compartmentss NA 50% Human Human -DTXSID9045978 Css NA 0.08837 mg/L 3compartmentss NA 95% Human Human -DTXSID9045978 Css NA 0.09488 mg/L PBTK NA 50% Human Human -DTXSID9045978 Css NA 0.592 mg/L PBTK NA 95% Human Human -DTXSID9045978 Clint NA 38.79 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045978 Fup NA 0.0621 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9045978 Vd NA 66.89 L/kg 1compartment NA NA Rat Human -DTXSID9045978 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID9045978 TK.Half.Life NA 15.1 hours 1compartment NA NA Rat Human -DTXSID9045978 Css NA 0.005314 mg/L 3compartmentss NA 50% Rat Human -DTXSID9045978 Css NA 0.03704 mg/L 3compartmentss NA 95% Rat Human -DTXSID9045978 Css NA 0.05152 mg/L PBTK NA 50% Rat Human -DTXSID9045978 Css NA 0.2699 mg/L PBTK NA 95% Rat Human -DTXSID9046023 Clint NA 6.028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046023 Fup NA 0.3625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046023 Vd NA 0.5125 L/kg 1compartment NA NA Human Human +DTXSID9045976 TK.Half.Life NA 0.7207 hours 1compartment NA NA Rat Human +DTXSID9045976 Css NA 0.03141 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045976 Css NA 0.1387 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045976 Css NA 0.02164 mg/L PBTK NA 50% Rat Human +DTXSID9045976 Css NA 0.08711 mg/L PBTK NA 95% Rat Human +DTXSID9045978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045978 Fup 0.0403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9045978 Vd NA 2.849 L/kg 1compartment NA NA Human Human +DTXSID9045978 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9045978 TK.Half.Life NA 7.396 hours 1compartment NA NA Human Human +DTXSID9045978 Css NA 0.2552 mg/L 3compartmentss NA 50% Human Human +DTXSID9045978 Css NA 2.281 mg/L 3compartmentss NA 95% Human Human +DTXSID9045978 Css NA 0.1921 mg/L PBTK NA 50% Human Human +DTXSID9045978 Css NA 1.554 mg/L PBTK NA 95% Human Human +DTXSID9045978 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045978 Fup 0.0403 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9045978 Vd NA 2.403 L/kg 1compartment NA NA Rat Human +DTXSID9045978 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9045978 TK.Half.Life NA 2.673 hours 1compartment NA NA Rat Human +DTXSID9045978 Css NA 0.03324 mg/L 3compartmentss NA 50% Rat Human +DTXSID9045978 Css NA 0.2421 mg/L 3compartmentss NA 95% Rat Human +DTXSID9045978 Css NA 0.02492 mg/L PBTK NA 50% Rat Human +DTXSID9045978 Css NA 0.1647 mg/L PBTK NA 95% Rat Human +DTXSID9046023 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046023 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046023 Vd NA 0.4766 L/kg 1compartment NA NA Human Human DTXSID9046023 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046023 TK.Half.Life NA 1.16 hours 1compartment NA NA Human Human -DTXSID9046023 Css NA 0.2025 mg/L 3compartmentss NA 50% Human Human -DTXSID9046023 Css NA 1.224 mg/L 3compartmentss NA 95% Human Human -DTXSID9046023 Css NA 0.1431 mg/L PBTK NA 50% Human Human -DTXSID9046023 Css NA 0.795 mg/L PBTK NA 95% Human Human -DTXSID9046023 Clint NA 6.028 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046023 Fup NA 0.3625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046023 Vd NA 0.5049 L/kg 1compartment NA NA Rat Human +DTXSID9046023 TK.Half.Life NA 1.187 hours 1compartment NA NA Human Human +DTXSID9046023 Css NA 0.2223 mg/L 3compartmentss NA 50% Human Human +DTXSID9046023 Css NA 1.403 mg/L 3compartmentss NA 95% Human Human +DTXSID9046023 Css NA 0.1536 mg/L PBTK NA 50% Human Human +DTXSID9046023 Css NA 0.9064 mg/L PBTK NA 95% Human Human +DTXSID9046023 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046023 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046023 Vd NA 0.4684 L/kg 1compartment NA NA Rat Human DTXSID9046023 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046023 TK.Half.Life NA 0.6412 hours 1compartment NA NA Rat Human -DTXSID9046023 Css NA 0.1009 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046023 Css NA 0.4892 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046023 Css NA 0.06785 mg/L PBTK NA 50% Rat Human -DTXSID9046023 Css NA 0.2948 mg/L PBTK NA 95% Rat Human -DTXSID9046029 Clint NA 3.523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046029 Fup NA 0.0184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046029 Vd NA 2.014 L/kg 1compartment NA NA Human Human -DTXSID9046029 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID9046029 TK.Half.Life NA 116.6 hours 1compartment NA NA Human Human -DTXSID9046029 Css NA 9.31 mg/L 3compartmentss NA 50% Human Human -DTXSID9046029 Css NA 62.67 mg/L 3compartmentss NA 95% Human Human -DTXSID9046029 Css NA 5.992 mg/L PBTK NA 50% Human Human -DTXSID9046029 Css NA 38.19 mg/L PBTK NA 95% Human Human -DTXSID9046029 Clint NA 3.523 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046029 Fup NA 0.0184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046029 Vd NA 1.497 L/kg 1compartment NA NA Rat Human -DTXSID9046029 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID9046029 TK.Half.Life NA 34.8 hours 1compartment NA NA Rat Human -DTXSID9046029 Css NA 4.816 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046029 Css NA 25.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046029 Css NA 2.919 mg/L PBTK NA 50% Rat Human -DTXSID9046029 Css NA 14.14 mg/L PBTK NA 95% Rat Human -DTXSID9046071 Clint NA 14.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046071 Fup NA 0.0639 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046071 Vd NA 2.147 L/kg 1compartment NA NA Human Human +DTXSID9046023 TK.Half.Life NA 0.6614 hours 1compartment NA NA Rat Human +DTXSID9046023 Css NA 0.02632 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046023 Css NA 0.1185 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046023 Css NA 0.01794 mg/L PBTK NA 50% Rat Human +DTXSID9046023 Css NA 0.07374 mg/L PBTK NA 95% Rat Human +DTXSID9046029 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046029 Fup 0.0203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046029 Vd NA 2.836 L/kg 1compartment NA NA Human Human +DTXSID9046029 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID9046029 TK.Half.Life NA 45.36 hours 1compartment NA NA Human Human +DTXSID9046029 Css NA 2.065 mg/L 3compartmentss NA 50% Human Human +DTXSID9046029 Css NA 13.92 mg/L 3compartmentss NA 95% Human Human +DTXSID9046029 Css NA 1.396 mg/L PBTK NA 50% Human Human +DTXSID9046029 Css NA 9.146 mg/L PBTK NA 95% Human Human +DTXSID9046029 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046029 Fup 0.0203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046029 Vd NA 2.122 L/kg 1compartment NA NA Rat Human +DTXSID9046029 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID9046029 TK.Half.Life NA 8.602 hours 1compartment NA NA Rat Human +DTXSID9046029 Css NA 0.2678 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046029 Css NA 1.535 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046029 Css NA 0.18 mg/L PBTK NA 50% Rat Human +DTXSID9046029 Css NA 1.007 mg/L PBTK NA 95% Rat Human +DTXSID9046071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046071 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046071 Vd NA 2.122 L/kg 1compartment NA NA Human Human DTXSID9046071 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046071 TK.Half.Life NA 13.04 hours 1compartment NA NA Human Human -DTXSID9046071 Css NA 0.7986 mg/L 3compartmentss NA 50% Human Human -DTXSID9046071 Css NA 5.289 mg/L 3compartmentss NA 95% Human Human -DTXSID9046071 Css NA 0.5462 mg/L PBTK NA 50% Human Human -DTXSID9046071 Css NA 3.45 mg/L PBTK NA 95% Human Human -DTXSID9046071 Clint NA 14.54 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046071 Fup NA 0.0639 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046071 Vd NA 1.694 L/kg 1compartment NA NA Rat Human +DTXSID9046071 TK.Half.Life NA 4.141 hours 1compartment NA NA Human Human +DTXSID9046071 Css NA 0.1396 mg/L 3compartmentss NA 50% Human Human +DTXSID9046071 Css NA 0.9858 mg/L 3compartmentss NA 95% Human Human +DTXSID9046071 Css NA 0.1078 mg/L PBTK NA 50% Human Human +DTXSID9046071 Css NA 0.7001 mg/L PBTK NA 95% Human Human +DTXSID9046071 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046071 Fup 0.173 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046071 Vd NA 1.8 L/kg 1compartment NA NA Rat Human DTXSID9046071 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046071 TK.Half.Life NA 4.615 hours 1compartment NA NA Rat Human -DTXSID9046071 Css NA 0.4394 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046071 Css NA 2.294 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046071 Css NA 0.2868 mg/L PBTK NA 50% Rat Human -DTXSID9046071 Css NA 1.394 mg/L PBTK NA 95% Rat Human -DTXSID9046073 Clint NA 0.4331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046073 Fup NA 0.2687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046073 Vd NA 0.3204 L/kg 1compartment NA NA Human Human +DTXSID9046071 TK.Half.Life NA 1.714 hours 1compartment NA NA Rat Human +DTXSID9046071 Css NA 0.01752 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046071 Css NA 0.09196 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046071 Css NA 0.01352 mg/L PBTK NA 50% Rat Human +DTXSID9046071 Css NA 0.06647 mg/L PBTK NA 95% Rat Human +DTXSID9046073 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046073 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046073 Vd NA 0.3834 L/kg 1compartment NA NA Human Human DTXSID9046073 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046073 TK.Half.Life NA 4.489 hours 1compartment NA NA Human Human -DTXSID9046073 Css NA 1.704 mg/L 3compartmentss NA 50% Human Human -DTXSID9046073 Css NA 6.808 mg/L 3compartmentss NA 95% Human Human -DTXSID9046073 Css NA 1.118 mg/L PBTK NA 50% Human Human -DTXSID9046073 Css NA 4.113 mg/L PBTK NA 95% Human Human -DTXSID9046073 Clint NA 0.4331 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046073 Fup NA 0.2687 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046073 Vd NA 0.3261 L/kg 1compartment NA NA Rat Human +DTXSID9046073 TK.Half.Life NA 6.2 hours 1compartment NA NA Human Human +DTXSID9046073 Css NA 1.357 mg/L 3compartmentss NA 50% Human Human +DTXSID9046073 Css NA 6.025 mg/L 3compartmentss NA 95% Human Human +DTXSID9046073 Css NA 0.9507 mg/L PBTK NA 50% Human Human +DTXSID9046073 Css NA 3.712 mg/L PBTK NA 95% Human Human +DTXSID9046073 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046073 Fup 0.4 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046073 Vd NA 0.3917 L/kg 1compartment NA NA Rat Human DTXSID9046073 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046073 TK.Half.Life NA 1.979 hours 1compartment NA NA Rat Human -DTXSID9046073 Css NA 0.6136 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046073 Css NA 2.008 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046073 Css NA 0.3824 mg/L PBTK NA 50% Rat Human -DTXSID9046073 Css NA 1.139 mg/L PBTK NA 95% Rat Human -DTXSID9046100 Clint NA 7.008 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046100 Fup NA 0.439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046100 Vd NA 0.86 L/kg 1compartment NA NA Human Human +DTXSID9046073 TK.Half.Life NA 2.158 hours 1compartment NA NA Rat Human +DTXSID9046073 Css NA 0.01128 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046073 Css NA 0.07738 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046073 Css NA 0.007468 mg/L PBTK NA 50% Rat Human +DTXSID9046073 Css NA 0.04748 mg/L PBTK NA 95% Rat Human +DTXSID9046100 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046100 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046100 Vd NA 0.9837 L/kg 1compartment NA NA Human Human DTXSID9046100 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046100 TK.Half.Life NA 1.527 hours 1compartment NA NA Human Human -DTXSID9046100 Css NA 0.1376 mg/L 3compartmentss NA 50% Human Human -DTXSID9046100 Css NA 0.9643 mg/L 3compartmentss NA 95% Human Human -DTXSID9046100 Css NA 0.1067 mg/L PBTK NA 50% Human Human -DTXSID9046100 Css NA 0.6618 mg/L PBTK NA 95% Human Human -DTXSID9046100 Clint NA 7.008 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046100 Fup NA 0.439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046100 Vd NA 0.7956 L/kg 1compartment NA NA Rat Human +DTXSID9046100 TK.Half.Life NA 1.205 hours 1compartment NA NA Human Human +DTXSID9046100 Css NA 0.06021 mg/L 3compartmentss NA 50% Human Human +DTXSID9046100 Css NA 0.4493 mg/L 3compartmentss NA 95% Human Human +DTXSID9046100 Css NA 0.04532 mg/L PBTK NA 50% Human Human +DTXSID9046100 Css NA 0.306 mg/L PBTK NA 95% Human Human +DTXSID9046100 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046100 Fup 0.337 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046100 Vd NA 0.8571 L/kg 1compartment NA NA Rat Human DTXSID9046100 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046100 TK.Half.Life NA 0.7708 hours 1compartment NA NA Rat Human -DTXSID9046100 Css NA 0.06801 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046100 Css NA 0.3754 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046100 Css NA 0.05152 mg/L PBTK NA 50% Rat Human -DTXSID9046100 Css NA 0.2439 mg/L PBTK NA 95% Rat Human -DTXSID9046102 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046102 Fup NA 0.283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046102 Vd NA 0.3051 L/kg 1compartment NA NA Human Human +DTXSID9046100 TK.Half.Life NA 0.5403 hours 1compartment NA NA Rat Human +DTXSID9046100 Css NA 0.007422 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046100 Css NA 0.04405 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046100 Css NA 0.005556 mg/L PBTK NA 50% Rat Human +DTXSID9046100 Css NA 0.03069 mg/L PBTK NA 95% Rat Human +DTXSID9046102 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046102 Fup 0.67 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046102 Vd NA 0.4569 L/kg 1compartment NA NA Human Human DTXSID9046102 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046102 TK.Half.Life NA 6.975 hours 1compartment NA NA Human Human -DTXSID9046102 Css NA 2.886 mg/L 3compartmentss NA 50% Human Human -DTXSID9046102 Css NA 10.47 mg/L 3compartmentss NA 95% Human Human -DTXSID9046102 Css NA 1.885 mg/L PBTK NA 50% Human Human -DTXSID9046102 Css NA 6.427 mg/L PBTK NA 95% Human Human -DTXSID9046102 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046102 Fup NA 0.283 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046102 Vd NA 0.3165 L/kg 1compartment NA NA Rat Human +DTXSID9046102 TK.Half.Life NA 4.412 hours 1compartment NA NA Human Human +DTXSID9046102 Css NA 0.663 mg/L 3compartmentss NA 50% Human Human +DTXSID9046102 Css NA 4.279 mg/L 3compartmentss NA 95% Human Human +DTXSID9046102 Css NA 0.494 mg/L PBTK NA 50% Human Human +DTXSID9046102 Css NA 2.634 mg/L PBTK NA 95% Human Human +DTXSID9046102 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046102 Fup 0.67 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046102 Vd NA 0.4791 L/kg 1compartment NA NA Rat Human DTXSID9046102 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046102 TK.Half.Life NA 2.466 hours 1compartment NA NA Rat Human -DTXSID9046102 Css NA 0.7915 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046102 Css NA 2.521 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046102 Css NA 0.4905 mg/L PBTK NA 50% Rat Human -DTXSID9046102 Css NA 1.43 mg/L PBTK NA 95% Rat Human -DTXSID9046104 Clint NA 12.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9046102 TK.Half.Life NA 1.577 hours 1compartment NA NA Rat Human +DTXSID9046102 Css NA 0.003489 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046102 Css NA 0.02427 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046102 Css NA 0.002504 mg/L PBTK NA 50% Rat Human +DTXSID9046102 Css NA 0.01435 mg/L PBTK NA 95% Rat Human +DTXSID9046104 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9046104 Fup 7e-04 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Human Human -DTXSID9046104 Vd NA 0.1611 L/kg 1compartment NA NA Human Human -DTXSID9046104 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID9046104 TK.Half.Life NA 69.79 hours 1compartment NA NA Human Human -DTXSID9046104 Css NA 83.2 mg/L 3compartmentss NA 50% Human Human -DTXSID9046104 Css NA 625.8 mg/L 3compartmentss NA 95% Human Human -DTXSID9046104 Css NA 48.22 mg/L PBTK NA 50% Human Human -DTXSID9046104 Css NA 365.1 mg/L PBTK NA 95% Human Human -DTXSID9046104 Clint NA 12.22 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9046104 Vd NA 0.1602 L/kg 1compartment NA NA Human Human +DTXSID9046104 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID9046104 TK.Half.Life NA 40.25 hours 1compartment NA NA Human Human +DTXSID9046104 Css NA 48.8 mg/L 3compartmentss NA 50% Human Human +DTXSID9046104 Css NA 405 mg/L 3compartmentss NA 95% Human Human +DTXSID9046104 Css NA 27.33 mg/L PBTK NA 50% Human Human +DTXSID9046104 Css NA 226.8 mg/L PBTK NA 95% Human Human +DTXSID9046104 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9046104 Fup 7e-04 NA NA Obach, R. S. (1999) Drug Metabolism and Disposition 27(11), 1350-9 NA Rat Human -DTXSID9046104 Vd NA 0.1593 L/kg 1compartment NA NA Rat Human -DTXSID9046104 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID9046104 TK.Half.Life NA 46.15 hours 1compartment NA NA Rat Human -DTXSID9046104 Css NA 46.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046104 Css NA 261.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046104 Css NA 25.01 mg/L PBTK NA 50% Rat Human -DTXSID9046104 Css NA 141.4 mg/L PBTK NA 95% Rat Human -DTXSID9046106 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046106 Fup NA 0.2293 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046106 Vd NA 0.2827 L/kg 1compartment NA NA Human Human +DTXSID9046104 Vd NA 0.1586 L/kg 1compartment NA NA Rat Human +DTXSID9046104 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID9046104 TK.Half.Life NA 27.17 hours 1compartment NA NA Rat Human +DTXSID9046104 Css NA 6.082 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046104 Css NA 37.72 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046104 Css NA 3.528 mg/L PBTK NA 50% Rat Human +DTXSID9046104 Css NA 21.88 mg/L PBTK NA 95% Rat Human +DTXSID9046106 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046106 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046106 Vd NA 0.3144 L/kg 1compartment NA NA Human Human DTXSID9046106 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046106 TK.Half.Life NA 7.975 hours 1compartment NA NA Human Human -DTXSID9046106 Css NA 3.602 mg/L 3compartmentss NA 50% Human Human -DTXSID9046106 Css NA 13.02 mg/L 3compartmentss NA 95% Human Human -DTXSID9046106 Css NA 2.303 mg/L PBTK NA 50% Human Human -DTXSID9046106 Css NA 7.785 mg/L PBTK NA 95% Human Human -DTXSID9046106 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046106 Fup NA 0.2293 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046106 Vd NA 0.2875 L/kg 1compartment NA NA Rat Human +DTXSID9046106 TK.Half.Life NA 0.8104 hours 1compartment NA NA Human Human +DTXSID9046106 Css NA 0.1216 mg/L 3compartmentss NA 50% Human Human +DTXSID9046106 Css NA 0.8594 mg/L 3compartmentss NA 95% Human Human +DTXSID9046106 Css NA 0.07997 mg/L PBTK NA 50% Human Human +DTXSID9046106 Css NA 0.5359 mg/L PBTK NA 95% Human Human +DTXSID9046106 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046106 Fup 0.3 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046106 Vd NA 0.3205 L/kg 1compartment NA NA Rat Human DTXSID9046106 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046106 TK.Half.Life NA 2.765 hours 1compartment NA NA Rat Human -DTXSID9046106 Css NA 0.999 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046106 Css NA 3.058 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046106 Css NA 0.6019 mg/L PBTK NA 50% Rat Human -DTXSID9046106 Css NA 1.718 mg/L PBTK NA 95% Rat Human -DTXSID9046108 Clint NA 2.857 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046108 Fup NA 0.4185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046108 Vd NA 0.8175 L/kg 1compartment NA NA Human Human +DTXSID9046106 TK.Half.Life NA 0.469 hours 1compartment NA NA Rat Human +DTXSID9046106 Css NA 0.001178 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046106 Css NA 0.006797 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046106 Css NA 0.0007341 mg/L PBTK NA 50% Rat Human +DTXSID9046106 Css NA 0.004017 mg/L PBTK NA 95% Rat Human +DTXSID9046108 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046108 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046108 Vd NA 0.6705 L/kg 1compartment NA NA Human Human DTXSID9046108 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046108 TK.Half.Life NA 2.638 hours 1compartment NA NA Human Human -DTXSID9046108 Css NA 0.3096 mg/L 3compartmentss NA 50% Human Human -DTXSID9046108 Css NA 1.822 mg/L 3compartmentss NA 95% Human Human -DTXSID9046108 Css NA 0.24 mg/L PBTK NA 50% Human Human -DTXSID9046108 Css NA 1.219 mg/L PBTK NA 95% Human Human -DTXSID9046108 Clint NA 2.857 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046108 Fup NA 0.4185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046108 Vd NA 0.7569 L/kg 1compartment NA NA Rat Human +DTXSID9046108 TK.Half.Life NA 0.8919 hours 1compartment NA NA Human Human +DTXSID9046108 Css NA 0.06954 mg/L 3compartmentss NA 50% Human Human +DTXSID9046108 Css NA 0.5412 mg/L 3compartmentss NA 95% Human Human +DTXSID9046108 Css NA 0.04936 mg/L PBTK NA 50% Human Human +DTXSID9046108 Css NA 0.3532 mg/L PBTK NA 95% Human Human +DTXSID9046108 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046108 Fup 0.292 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046108 Vd NA 0.6183 L/kg 1compartment NA NA Rat Human DTXSID9046108 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046108 TK.Half.Life NA 1.318 hours 1compartment NA NA Rat Human -DTXSID9046108 Css NA 0.1442 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046108 Css NA 0.6578 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046108 Css NA 0.107 mg/L PBTK NA 50% Rat Human -DTXSID9046108 Css NA 0.4045 mg/L PBTK NA 95% Rat Human -DTXSID9046150 Clint NA 31.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046150 Fup NA 0.2745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046150 Vd NA 2.581 L/kg 1compartment NA NA Human Human +DTXSID9046108 TK.Half.Life NA 0.4351 hours 1compartment NA NA Rat Human +DTXSID9046108 Css NA 0.008817 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046108 Css NA 0.05223 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046108 Css NA 0.006263 mg/L PBTK NA 50% Rat Human +DTXSID9046108 Css NA 0.03333 mg/L PBTK NA 95% Rat Human +DTXSID9046150 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046150 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046150 Vd NA 3.105 L/kg 1compartment NA NA Human Human DTXSID9046150 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046150 TK.Half.Life NA 2.936 hours 1compartment NA NA Human Human -DTXSID9046150 Css NA 0.05474 mg/L 3compartmentss NA 50% Human Human -DTXSID9046150 Css NA 0.3909 mg/L 3compartmentss NA 95% Human Human -DTXSID9046150 Css NA 0.04898 mg/L PBTK NA 50% Human Human -DTXSID9046150 Css NA 0.3154 mg/L PBTK NA 95% Human Human -DTXSID9046150 Clint NA 31.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046150 Fup NA 0.2745 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046150 Vd NA 2.335 L/kg 1compartment NA NA Rat Human +DTXSID9046150 TK.Half.Life NA 7.075 hours 1compartment NA NA Human Human +DTXSID9046150 Css NA 0.1594 mg/L 3compartmentss NA 50% Human Human +DTXSID9046150 Css NA 1.112 mg/L 3compartmentss NA 95% Human Human +DTXSID9046150 Css NA 0.1573 mg/L PBTK NA 50% Human Human +DTXSID9046150 Css NA 0.9309 mg/L PBTK NA 95% Human Human +DTXSID9046150 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046150 Fup 0.426 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046150 Vd NA 2.847 L/kg 1compartment NA NA Rat Human DTXSID9046150 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046150 TK.Half.Life NA 1.278 hours 1compartment NA NA Rat Human -DTXSID9046150 Css NA 0.02961 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046150 Css NA 0.1637 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046150 Css NA 0.02553 mg/L PBTK NA 50% Rat Human -DTXSID9046150 Css NA 0.1251 mg/L PBTK NA 95% Rat Human -DTXSID9046152 Clint NA 673 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046152 Fup NA 0.0449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046152 Vd NA 1.986 L/kg 1compartment NA NA Human Human +DTXSID9046150 TK.Half.Life NA 3.002 hours 1compartment NA NA Rat Human +DTXSID9046150 Css NA 0.01802 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046150 Css NA 0.09614 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046150 Css NA 0.01848 mg/L PBTK NA 50% Rat Human +DTXSID9046150 Css NA 0.07377 mg/L PBTK NA 95% Rat Human +DTXSID9046152 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046152 Fup 0.0545 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046152 Vd NA 1.869 L/kg 1compartment NA NA Human Human DTXSID9046152 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046152 TK.Half.Life NA 2.027 hours 1compartment NA NA Human Human -DTXSID9046152 Css NA 0.02647 mg/L 3compartmentss NA 50% Human Human -DTXSID9046152 Css NA 0.1984 mg/L 3compartmentss NA 95% Human Human -DTXSID9046152 Css NA 0.01727 mg/L PBTK NA 50% Human Human -DTXSID9046152 Css NA 0.1253 mg/L PBTK NA 95% Human Human -DTXSID9046152 Clint NA 673 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046152 Fup NA 0.0449 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046152 Vd NA 1.486 L/kg 1compartment NA NA Rat Human +DTXSID9046152 TK.Half.Life NA 9.104 hours 1compartment NA NA Human Human +DTXSID9046152 Css NA 0.6254 mg/L 3compartmentss NA 50% Human Human +DTXSID9046152 Css NA 4.53 mg/L 3compartmentss NA 95% Human Human +DTXSID9046152 Css NA 0.4076 mg/L PBTK NA 50% Human Human +DTXSID9046152 Css NA 2.869 mg/L PBTK NA 95% Human Human +DTXSID9046152 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046152 Fup 0.0545 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046152 Vd NA 1.403 L/kg 1compartment NA NA Rat Human DTXSID9046152 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046152 TK.Half.Life NA 0.6652 hours 1compartment NA NA Rat Human -DTXSID9046152 Css NA 0.01488 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046152 Css NA 0.09214 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046152 Css NA 0.009172 mg/L PBTK NA 50% Rat Human -DTXSID9046152 Css NA 0.05482 mg/L PBTK NA 95% Rat Human -DTXSID9046154 Clint NA 2.612 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046154 Fup NA 0.1726 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046154 Vd NA 0.7352 L/kg 1compartment NA NA Human Human +DTXSID9046152 TK.Half.Life NA 3.127 hours 1compartment NA NA Rat Human +DTXSID9046152 Css NA 0.08152 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046152 Css NA 0.4893 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046152 Css NA 0.05222 mg/L PBTK NA 50% Rat Human +DTXSID9046152 Css NA 0.3014 mg/L PBTK NA 95% Rat Human +DTXSID9046154 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046154 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046154 Vd NA 0.7657 L/kg 1compartment NA NA Human Human DTXSID9046154 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046154 TK.Half.Life NA 5.7 hours 1compartment NA NA Human Human -DTXSID9046154 Css NA 0.9206 mg/L 3compartmentss NA 50% Human Human -DTXSID9046154 Css NA 4.432 mg/L 3compartmentss NA 95% Human Human -DTXSID9046154 Css NA 0.6174 mg/L PBTK NA 50% Human Human -DTXSID9046154 Css NA 2.805 mg/L PBTK NA 95% Human Human -DTXSID9046154 Clint NA 2.612 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046154 Fup NA 0.1726 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046154 Vd NA 0.609 L/kg 1compartment NA NA Rat Human +DTXSID9046154 TK.Half.Life NA 1.429 hours 1compartment NA NA Human Human +DTXSID9046154 Css NA 0.1346 mg/L 3compartmentss NA 50% Human Human +DTXSID9046154 Css NA 0.9771 mg/L 3compartmentss NA 95% Human Human +DTXSID9046154 Css NA 0.08982 mg/L PBTK NA 50% Human Human +DTXSID9046154 Css NA 0.6203 mg/L PBTK NA 95% Human Human +DTXSID9046154 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046154 Fup 0.166 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046154 Vd NA 0.6288 L/kg 1compartment NA NA Rat Human DTXSID9046154 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046154 TK.Half.Life NA 2.571 hours 1compartment NA NA Rat Human -DTXSID9046154 Css NA 0.4308 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046154 Css NA 1.552 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046154 Css NA 0.2738 mg/L PBTK NA 50% Rat Human -DTXSID9046154 Css NA 0.9074 mg/L PBTK NA 95% Rat Human -DTXSID9046156 Clint NA 0.7143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046156 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046156 Vd NA 1.257 L/kg 1compartment NA NA Human Human -DTXSID9046156 Days.Css NA 46 Days PBTK NA NA Human Human -DTXSID9046156 TK.Half.Life NA 206.9 hours 1compartment NA NA Human Human -DTXSID9046156 Css NA 26.92 mg/L 3compartmentss NA 50% Human Human -DTXSID9046156 Css NA 162.1 mg/L 3compartmentss NA 95% Human Human -DTXSID9046156 Css NA 16.72 mg/L PBTK NA 50% Human Human -DTXSID9046156 Css NA 94.27 mg/L PBTK NA 95% Human Human -DTXSID9046156 Clint NA 0.7143 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046156 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046156 Vd NA 0.9326 L/kg 1compartment NA NA Rat Human -DTXSID9046156 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID9046156 TK.Half.Life NA 63.83 hours 1compartment NA NA Rat Human -DTXSID9046156 Css NA 11.1 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046156 Css NA 56.79 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046156 Css NA 6.464 mg/L PBTK NA 50% Rat Human -DTXSID9046156 Css NA 31.16 mg/L PBTK NA 95% Rat Human -DTXSID9046158 Clint NA 0.3634 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046158 Fup NA 0.0092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046158 Vd NA 0.1911 L/kg 1compartment NA NA Human Human -DTXSID9046158 Days.Css NA 17 Days PBTK NA NA Human Human -DTXSID9046158 TK.Half.Life NA 83.52 hours 1compartment NA NA Human Human -DTXSID9046158 Css NA 74.6 mg/L 3compartmentss NA 50% Human Human -DTXSID9046158 Css NA 480.5 mg/L 3compartmentss NA 95% Human Human -DTXSID9046158 Css NA 43.7 mg/L PBTK NA 50% Human Human -DTXSID9046158 Css NA 279.3 mg/L PBTK NA 95% Human Human -DTXSID9046158 Clint NA 0.3634 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046158 Fup NA 0.0092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046158 Vd NA 0.1838 L/kg 1compartment NA NA Rat Human -DTXSID9046158 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID9046158 TK.Half.Life NA 33.99 hours 1compartment NA NA Rat Human -DTXSID9046158 Css NA 26.88 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046158 Css NA 155.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046158 Css NA 14.65 mg/L PBTK NA 50% Rat Human -DTXSID9046158 Css NA 84.31 mg/L PBTK NA 95% Rat Human -DTXSID9046231 Clint NA 5.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046231 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046231 Vd NA 0.3538 L/kg 1compartment NA NA Human Human +DTXSID9046154 TK.Half.Life NA 0.6442 hours 1compartment NA NA Rat Human +DTXSID9046154 Css NA 0.01744 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046154 Css NA 0.09228 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046154 Css NA 0.01148 mg/L PBTK NA 50% Rat Human +DTXSID9046154 Css NA 0.05846 mg/L PBTK NA 95% Rat Human +DTXSID9046156 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046156 Fup 0.00432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046156 Vd NA 0.6068 L/kg 1compartment NA NA Human Human +DTXSID9046156 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9046156 TK.Half.Life NA 19.15 hours 1compartment NA NA Human Human +DTXSID9046156 Css NA 5.022 mg/L 3compartmentss NA 50% Human Human +DTXSID9046156 Css NA 50.01 mg/L 3compartmentss NA 95% Human Human +DTXSID9046156 Css NA 2.973 mg/L PBTK NA 50% Human Human +DTXSID9046156 Css NA 29.34 mg/L PBTK NA 95% Human Human +DTXSID9046156 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046156 Fup 0.00432 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046156 Vd NA 0.4516 L/kg 1compartment NA NA Rat Human +DTXSID9046156 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9046156 TK.Half.Life NA 9.239 hours 1compartment NA NA Rat Human +DTXSID9046156 Css NA 0.2536 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046156 Css NA 2.53 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046156 Css NA 0.142 mg/L PBTK NA 50% Rat Human +DTXSID9046156 Css NA 1.423 mg/L PBTK NA 95% Rat Human +DTXSID9046158 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046158 Fup 0.0575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046158 Vd NA 0.2966 L/kg 1compartment NA NA Human Human +DTXSID9046158 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046158 TK.Half.Life NA 1.155 hours 1compartment NA NA Human Human +DTXSID9046158 Css NA 0.5303 mg/L 3compartmentss NA 50% Human Human +DTXSID9046158 Css NA 4.304 mg/L 3compartmentss NA 95% Human Human +DTXSID9046158 Css NA 0.325 mg/L PBTK NA 50% Human Human +DTXSID9046158 Css NA 2.533 mg/L PBTK NA 95% Human Human +DTXSID9046158 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046158 Fup 0.0575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046158 Vd NA 0.2811 L/kg 1compartment NA NA Rat Human +DTXSID9046158 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046158 TK.Half.Life NA 0.6796 hours 1compartment NA NA Rat Human +DTXSID9046158 Css NA 0.06963 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046158 Css NA 0.4229 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046158 Css NA 0.04114 mg/L PBTK NA 50% Rat Human +DTXSID9046158 Css NA 0.2427 mg/L PBTK NA 95% Rat Human +DTXSID9046231 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046231 Fup 0.0935 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046231 Vd NA 0.3807 L/kg 1compartment NA NA Human Human DTXSID9046231 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046231 TK.Half.Life NA 3.577 hours 1compartment NA NA Human Human -DTXSID9046231 Css NA 1.621 mg/L 3compartmentss NA 50% Human Human -DTXSID9046231 Css NA 11.13 mg/L 3compartmentss NA 95% Human Human -DTXSID9046231 Css NA 1.011 mg/L PBTK NA 50% Human Human -DTXSID9046231 Css NA 6.682 mg/L PBTK NA 95% Human Human -DTXSID9046231 Clint NA 5.946 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046231 Fup NA 0.0637 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046231 Vd NA 0.3471 L/kg 1compartment NA NA Rat Human +DTXSID9046231 TK.Half.Life NA 2.6 hours 1compartment NA NA Human Human +DTXSID9046231 Css NA 0.9742 mg/L 3compartmentss NA 50% Human Human +DTXSID9046231 Css NA 6.946 mg/L 3compartmentss NA 95% Human Human +DTXSID9046231 Css NA 0.6206 mg/L PBTK NA 50% Human Human +DTXSID9046231 Css NA 4.206 mg/L PBTK NA 95% Human Human +DTXSID9046231 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046231 Fup 0.0935 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046231 Vd NA 0.3759 L/kg 1compartment NA NA Rat Human DTXSID9046231 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046231 TK.Half.Life NA 2.174 hours 1compartment NA NA Rat Human -DTXSID9046231 Css NA 0.856 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046231 Css NA 4.161 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046231 Css NA 0.5017 mg/L PBTK NA 50% Rat Human -DTXSID9046231 Css NA 2.324 mg/L PBTK NA 95% Rat Human -DTXSID9046233 Clint NA 48.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046233 Fup NA 0.2026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046233 Vd NA 0.743 L/kg 1compartment NA NA Human Human -DTXSID9046233 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046233 TK.Half.Life NA 0.8883 hours 1compartment NA NA Human Human -DTXSID9046233 Css NA 0.05152 mg/L 3compartmentss NA 50% Human Human -DTXSID9046233 Css NA 0.3709 mg/L 3compartmentss NA 95% Human Human -DTXSID9046233 Css NA 0.03524 mg/L PBTK NA 50% Human Human -DTXSID9046233 Css NA 0.2395 mg/L PBTK NA 95% Human Human -DTXSID9046233 Clint NA 48.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046233 Fup NA 0.2026 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046233 Vd NA 0.6303 L/kg 1compartment NA NA Rat Human +DTXSID9046231 TK.Half.Life NA 1.572 hours 1compartment NA NA Rat Human +DTXSID9046231 Css NA 0.1204 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046231 Css NA 0.623 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046231 Css NA 0.07458 mg/L PBTK NA 50% Rat Human +DTXSID9046231 Css NA 0.3626 mg/L PBTK NA 95% Rat Human +DTXSID9046233 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046233 Fup 0.421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046233 Vd NA 1.109 L/kg 1compartment NA NA Human Human +DTXSID9046233 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9046233 TK.Half.Life NA 19 hours 1compartment NA NA Human Human +DTXSID9046233 Css NA 1.776 mg/L 3compartmentss NA 50% Human Human +DTXSID9046233 Css NA 7.749 mg/L 3compartmentss NA 95% Human Human +DTXSID9046233 Css NA 1.385 mg/L PBTK NA 50% Human Human +DTXSID9046233 Css NA 5.08 mg/L PBTK NA 95% Human Human +DTXSID9046233 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046233 Fup 0.421 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046233 Vd NA 0.9458 L/kg 1compartment NA NA Rat Human DTXSID9046233 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046233 TK.Half.Life NA 0.3806 hours 1compartment NA NA Rat Human -DTXSID9046233 Css NA 0.02879 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046233 Css NA 0.1625 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046233 Css NA 0.0186 mg/L PBTK NA 50% Rat Human -DTXSID9046233 Css NA 0.1002 mg/L PBTK NA 95% Rat Human -DTXSID9046235 Clint NA 0.5905 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046235 Fup NA 0.0227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046235 Vd NA 0.7231 L/kg 1compartment NA NA Human Human -DTXSID9046235 Days.Css NA 21 Days PBTK NA NA Human Human -DTXSID9046235 TK.Half.Life NA 103.9 hours 1compartment NA NA Human Human -DTXSID9046235 Css NA 24.49 mg/L 3compartmentss NA 50% Human Human -DTXSID9046235 Css NA 154.7 mg/L 3compartmentss NA 95% Human Human -DTXSID9046235 Css NA 14.7 mg/L PBTK NA 50% Human Human -DTXSID9046235 Css NA 90.23 mg/L PBTK NA 95% Human Human -DTXSID9046235 Clint NA 0.5905 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046235 Fup NA 0.0227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046235 Vd NA 0.5476 L/kg 1compartment NA NA Rat Human -DTXSID9046235 Days.Css NA 6 Days PBTK NA NA Rat Human -DTXSID9046235 TK.Half.Life NA 34.76 hours 1compartment NA NA Rat Human -DTXSID9046235 Css NA 9.492 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046235 Css NA 52.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046235 Css NA 5.339 mg/L PBTK NA 50% Rat Human -DTXSID9046235 Css NA 28.69 mg/L PBTK NA 95% Rat Human -DTXSID9046237 Clint NA 30.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046237 Fup NA 0.0462 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046237 Vd NA 2.823 L/kg 1compartment NA NA Human Human -DTXSID9046237 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9046237 TK.Half.Life NA 21.66 hours 1compartment NA NA Human Human -DTXSID9046237 Css NA 0.946 mg/L 3compartmentss NA 50% Human Human -DTXSID9046237 Css NA 5.958 mg/L 3compartmentss NA 95% Human Human -DTXSID9046237 Css NA 0.6427 mg/L PBTK NA 50% Human Human -DTXSID9046237 Css NA 3.902 mg/L PBTK NA 95% Human Human -DTXSID9046237 Clint NA 30.03 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046237 Fup NA 0.0462 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046237 Vd NA 2.118 L/kg 1compartment NA NA Rat Human -DTXSID9046237 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9046237 TK.Half.Life NA 4.398 hours 1compartment NA NA Rat Human -DTXSID9046237 Css NA 0.524 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046237 Css NA 2.769 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046237 Css NA 0.3407 mg/L PBTK NA 50% Rat Human -DTXSID9046237 Css NA 1.754 mg/L PBTK NA 95% Rat Human -DTXSID9046239 Clint NA 0.3297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046239 Fup NA 0.6195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046239 Vd NA 1.189 L/kg 1compartment NA NA Human Human +DTXSID9046233 TK.Half.Life NA 5.089 hours 1compartment NA NA Rat Human +DTXSID9046233 Css NA 0.1111 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046233 Css NA 0.4317 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046233 Css NA 0.0862 mg/L PBTK NA 50% Rat Human +DTXSID9046233 Css NA 0.2714 mg/L PBTK NA 95% Rat Human +DTXSID9046235 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046235 Fup 0.0315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046235 Vd NA 0.8359 L/kg 1compartment NA NA Human Human +DTXSID9046235 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9046235 TK.Half.Life NA 15.12 hours 1compartment NA NA Human Human +DTXSID9046235 Css NA 3.076 mg/L 3compartmentss NA 50% Human Human +DTXSID9046235 Css NA 24.91 mg/L 3compartmentss NA 95% Human Human +DTXSID9046235 Css NA 1.878 mg/L PBTK NA 50% Human Human +DTXSID9046235 Css NA 14.87 mg/L PBTK NA 95% Human Human +DTXSID9046235 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046235 Fup 0.0315 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046235 Vd NA 0.6333 L/kg 1compartment NA NA Rat Human +DTXSID9046235 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046235 TK.Half.Life NA 6.743 hours 1compartment NA NA Rat Human +DTXSID9046235 Css NA 0.3816 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046235 Css NA 2.379 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046235 Css NA 0.2259 mg/L PBTK NA 50% Rat Human +DTXSID9046235 Css NA 1.351 mg/L PBTK NA 95% Rat Human +DTXSID9046237 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046237 Fup 0.0541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046237 Vd NA 2.953 L/kg 1compartment NA NA Human Human +DTXSID9046237 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9046237 TK.Half.Life NA 35.15 hours 1compartment NA NA Human Human +DTXSID9046237 Css NA 1.44 mg/L 3compartmentss NA 50% Human Human +DTXSID9046237 Css NA 9.122 mg/L 3compartmentss NA 95% Human Human +DTXSID9046237 Css NA 0.9982 mg/L PBTK NA 50% Human Human +DTXSID9046237 Css NA 6.139 mg/L PBTK NA 95% Human Human +DTXSID9046237 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046237 Fup 0.0541 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046237 Vd NA 2.216 L/kg 1compartment NA NA Rat Human +DTXSID9046237 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9046237 TK.Half.Life NA 6.123 hours 1compartment NA NA Rat Human +DTXSID9046237 Css NA 0.1821 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046237 Css NA 1.011 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046237 Css NA 0.1249 mg/L PBTK NA 50% Rat Human +DTXSID9046237 Css NA 0.665 mg/L PBTK NA 95% Rat Human +DTXSID9046239 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046239 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046239 Vd NA 0.9187 L/kg 1compartment NA NA Human Human DTXSID9046239 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046239 TK.Half.Life NA 8.693 hours 1compartment NA NA Human Human -DTXSID9046239 Css NA 0.7355 mg/L 3compartmentss NA 50% Human Human -DTXSID9046239 Css NA 5.226 mg/L 3compartmentss NA 95% Human Human -DTXSID9046239 Css NA 0.634 mg/L PBTK NA 50% Human Human -DTXSID9046239 Css NA 3.33 mg/L PBTK NA 95% Human Human -DTXSID9046239 Clint NA 0.3297 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046239 Fup NA 0.6195 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046239 Vd NA 1.077 L/kg 1compartment NA NA Rat Human +DTXSID9046239 TK.Half.Life NA 1.927 hours 1compartment NA NA Human Human +DTXSID9046239 Css NA 0.1676 mg/L 3compartmentss NA 50% Human Human +DTXSID9046239 Css NA 1.105 mg/L 3compartmentss NA 95% Human Human +DTXSID9046239 Css NA 0.1285 mg/L PBTK NA 50% Human Human +DTXSID9046239 Css NA 0.7569 mg/L PBTK NA 95% Human Human +DTXSID9046239 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046239 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046239 Vd NA 0.8267 L/kg 1compartment NA NA Rat Human DTXSID9046239 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046239 TK.Half.Life NA 3.085 hours 1compartment NA NA Rat Human -DTXSID9046239 Css NA 0.2446 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046239 Css NA 1.608 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046239 Css NA 0.2044 mg/L PBTK NA 50% Rat Human -DTXSID9046239 Css NA 0.9637 mg/L PBTK NA 95% Rat Human -DTXSID9046281 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046281 Fup NA 0.0988 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046281 Vd NA 1.2 L/kg 1compartment NA NA Human Human -DTXSID9046281 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID9046281 TK.Half.Life NA 87.94 hours 1compartment NA NA Human Human -DTXSID9046281 Css NA 10.46 mg/L 3compartmentss NA 50% Human Human -DTXSID9046281 Css NA 46.05 mg/L 3compartmentss NA 95% Human Human -DTXSID9046281 Css NA 7.034 mg/L PBTK NA 50% Human Human -DTXSID9046281 Css NA 27.82 mg/L PBTK NA 95% Human Human -DTXSID9046281 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046281 Fup NA 0.0988 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046281 Vd NA 1.025 L/kg 1compartment NA NA Rat Human -DTXSID9046281 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9046281 TK.Half.Life NA 23.53 hours 1compartment NA NA Rat Human -DTXSID9046281 Css NA 2.91 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046281 Css NA 11.4 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046281 Css NA 1.84 mg/L PBTK NA 50% Rat Human -DTXSID9046281 Css NA 6.456 mg/L PBTK NA 95% Rat Human -DTXSID9046283 Clint NA 12.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046283 Fup NA 0.1107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046283 Vd NA 2.101 L/kg 1compartment NA NA Human Human +DTXSID9046239 TK.Half.Life NA 0.9498 hours 1compartment NA NA Rat Human +DTXSID9046239 Css NA 0.01892 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046239 Css NA 0.09731 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046239 Css NA 0.01456 mg/L PBTK NA 50% Rat Human +DTXSID9046239 Css NA 0.06472 mg/L PBTK NA 95% Rat Human +DTXSID9046281 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046281 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046281 Vd NA 1.87 L/kg 1compartment NA NA Human Human +DTXSID9046281 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046281 TK.Half.Life NA 11.77 hours 1compartment NA NA Human Human +DTXSID9046281 Css NA 0.7698 mg/L 3compartmentss NA 50% Human Human +DTXSID9046281 Css NA 5.158 mg/L 3compartmentss NA 95% Human Human +DTXSID9046281 Css NA 0.546 mg/L PBTK NA 50% Human Human +DTXSID9046281 Css NA 3.34 mg/L PBTK NA 95% Human Human +DTXSID9046281 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046281 Fup 0.123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046281 Vd NA 1.535 L/kg 1compartment NA NA Rat Human +DTXSID9046281 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046281 TK.Half.Life NA 4.757 hours 1compartment NA NA Rat Human +DTXSID9046281 Css NA 0.0933 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046281 Css NA 0.4592 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046281 Css NA 0.06523 mg/L PBTK NA 50% Rat Human +DTXSID9046281 Css NA 0.288 mg/L PBTK NA 95% Rat Human +DTXSID9046283 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046283 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046283 Vd NA 2.514 L/kg 1compartment NA NA Human Human DTXSID9046283 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046283 TK.Half.Life NA 7.046 hours 1compartment NA NA Human Human -DTXSID9046283 Css NA 0.3648 mg/L 3compartmentss NA 50% Human Human -DTXSID9046283 Css NA 2.831 mg/L 3compartmentss NA 95% Human Human -DTXSID9046283 Css NA 0.2794 mg/L PBTK NA 50% Human Human -DTXSID9046283 Css NA 1.919 mg/L PBTK NA 95% Human Human -DTXSID9046283 Clint NA 12.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046283 Fup NA 0.1107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046283 Vd NA 1.892 L/kg 1compartment NA NA Rat Human +DTXSID9046283 TK.Half.Life NA 11.01 hours 1compartment NA NA Human Human +DTXSID9046283 Css NA 0.4913 mg/L 3compartmentss NA 50% Human Human +DTXSID9046283 Css NA 3.219 mg/L 3compartmentss NA 95% Human Human +DTXSID9046283 Css NA 0.3378 mg/L PBTK NA 50% Human Human +DTXSID9046283 Css NA 2.137 mg/L PBTK NA 95% Human Human +DTXSID9046283 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046283 Fup 0.103 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046283 Vd NA 1.895 L/kg 1compartment NA NA Rat Human DTXSID9046283 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046283 TK.Half.Life NA 3.445 hours 1compartment NA NA Rat Human -DTXSID9046283 Css NA 0.1965 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046283 Css NA 1.171 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046283 Css NA 0.1436 mg/L PBTK NA 50% Rat Human -DTXSID9046283 Css NA 0.7475 mg/L PBTK NA 95% Rat Human -DTXSID9046285 Clint NA 52.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046285 Fup NA 0.1613 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046285 Vd NA 2.413 L/kg 1compartment NA NA Human Human +DTXSID9046283 TK.Half.Life NA 2.871 hours 1compartment NA NA Rat Human +DTXSID9046283 Css NA 0.06176 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046283 Css NA 0.3378 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046283 Css NA 0.04221 mg/L PBTK NA 50% Rat Human +DTXSID9046283 Css NA 0.222 mg/L PBTK NA 95% Rat Human +DTXSID9046285 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046285 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046285 Vd NA 2.883 L/kg 1compartment NA NA Human Human DTXSID9046285 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046285 TK.Half.Life NA 2.736 hours 1compartment NA NA Human Human -DTXSID9046285 Css NA 0.0563 mg/L 3compartmentss NA 50% Human Human -DTXSID9046285 Css NA 0.4443 mg/L 3compartmentss NA 95% Human Human -DTXSID9046285 Css NA 0.04638 mg/L PBTK NA 50% Human Human -DTXSID9046285 Css NA 0.3215 mg/L PBTK NA 95% Human Human -DTXSID9046285 Clint NA 52.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046285 Fup NA 0.1613 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046285 Vd NA 2.181 L/kg 1compartment NA NA Rat Human +DTXSID9046285 TK.Half.Life NA 13.04 hours 1compartment NA NA Human Human +DTXSID9046285 Css NA 0.393 mg/L 3compartmentss NA 50% Human Human +DTXSID9046285 Css NA 2.353 mg/L 3compartmentss NA 95% Human Human +DTXSID9046285 Css NA 0.3371 mg/L PBTK NA 50% Human Human +DTXSID9046285 Css NA 1.849 mg/L PBTK NA 95% Human Human +DTXSID9046285 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046285 Fup 0.183 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046285 Vd NA 2.54 L/kg 1compartment NA NA Rat Human DTXSID9046285 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046285 TK.Half.Life NA 1.208 hours 1compartment NA NA Rat Human -DTXSID9046285 Css NA 0.03072 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046285 Css NA 0.1933 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046285 Css NA 0.02438 mg/L PBTK NA 50% Rat Human -DTXSID9046285 Css NA 0.1323 mg/L PBTK NA 95% Rat Human -DTXSID9046287 Clint NA 30.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046287 Fup NA 0.1606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046287 Vd NA 0.6697 L/kg 1compartment NA NA Human Human +DTXSID9046285 TK.Half.Life NA 5.146 hours 1compartment NA NA Rat Human +DTXSID9046285 Css NA 0.0471 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046285 Css NA 0.2024 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046285 Css NA 0.04102 mg/L PBTK NA 50% Rat Human +DTXSID9046285 Css NA 0.1524 mg/L PBTK NA 95% Rat Human +DTXSID9046287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046287 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046287 Vd NA 0.6342 L/kg 1compartment NA NA Human Human DTXSID9046287 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046287 TK.Half.Life NA 1.066 hours 1compartment NA NA Human Human -DTXSID9046287 Css NA 0.1129 mg/L 3compartmentss NA 50% Human Human -DTXSID9046287 Css NA 0.9182 mg/L 3compartmentss NA 95% Human Human -DTXSID9046287 Css NA 0.07445 mg/L PBTK NA 50% Human Human -DTXSID9046287 Css NA 0.5701 mg/L PBTK NA 95% Human Human -DTXSID9046287 Clint NA 30.42 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046287 Fup NA 0.1606 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046287 Vd NA 0.5777 L/kg 1compartment NA NA Rat Human +DTXSID9046287 TK.Half.Life NA 1.276 hours 1compartment NA NA Human Human +DTXSID9046287 Css NA 0.1754 mg/L 3compartmentss NA 50% Human Human +DTXSID9046287 Css NA 1.435 mg/L 3compartmentss NA 95% Human Human +DTXSID9046287 Css NA 0.114 mg/L PBTK NA 50% Human Human +DTXSID9046287 Css NA 0.8928 mg/L PBTK NA 95% Human Human +DTXSID9046287 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046287 Fup 0.145 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046287 Vd NA 0.5468 L/kg 1compartment NA NA Rat Human DTXSID9046287 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046287 TK.Half.Life NA 0.4983 hours 1compartment NA NA Rat Human -DTXSID9046287 Css NA 0.0637 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046287 Css NA 0.3806 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046287 Css NA 0.03984 mg/L PBTK NA 50% Rat Human -DTXSID9046287 Css NA 0.2255 mg/L PBTK NA 95% Rat Human -DTXSID9046289 Clint NA 40.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046289 Fup NA 0.1054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046289 Vd NA 1.34 L/kg 1compartment NA NA Human Human +DTXSID9046287 TK.Half.Life NA 0.6205 hours 1compartment NA NA Rat Human +DTXSID9046287 Css NA 0.02295 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046287 Css NA 0.1404 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046287 Css NA 0.01458 mg/L PBTK NA 50% Rat Human +DTXSID9046287 Css NA 0.08566 mg/L PBTK NA 95% Rat Human +DTXSID9046289 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046289 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046289 Vd NA 1.749 L/kg 1compartment NA NA Human Human DTXSID9046289 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046289 TK.Half.Life NA 2.43 hours 1compartment NA NA Human Human -DTXSID9046289 Css NA 0.1559 mg/L 3compartmentss NA 50% Human Human -DTXSID9046289 Css NA 1.215 mg/L 3compartmentss NA 95% Human Human -DTXSID9046289 Css NA 0.1028 mg/L PBTK NA 50% Human Human -DTXSID9046289 Css NA 0.7698 mg/L PBTK NA 95% Human Human -DTXSID9046289 Clint NA 40.97 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046289 Fup NA 0.1054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046289 Vd NA 1.034 L/kg 1compartment NA NA Rat Human +DTXSID9046289 TK.Half.Life NA 6.406 hours 1compartment NA NA Human Human +DTXSID9046289 Css NA 0.3445 mg/L 3compartmentss NA 50% Human Human +DTXSID9046289 Css NA 2.024 mg/L 3compartmentss NA 95% Human Human +DTXSID9046289 Css NA 0.2559 mg/L PBTK NA 50% Human Human +DTXSID9046289 Css NA 1.377 mg/L PBTK NA 95% Human Human +DTXSID9046289 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046289 Fup 0.249 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046289 Vd NA 1.377 L/kg 1compartment NA NA Rat Human DTXSID9046289 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046289 TK.Half.Life NA 0.952 hours 1compartment NA NA Rat Human -DTXSID9046289 Css NA 0.08768 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046289 Css NA 0.5425 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046289 Css NA 0.05468 mg/L PBTK NA 50% Rat Human -DTXSID9046289 Css NA 0.3242 mg/L PBTK NA 95% Rat Human -DTXSID9046310 Clint NA 137.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046310 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046310 Vd NA 2.618 L/kg 1compartment NA NA Human Human -DTXSID9046310 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046310 TK.Half.Life NA 4.557 hours 1compartment NA NA Human Human -DTXSID9046310 Css NA 0.14 mg/L 3compartmentss NA 50% Human Human -DTXSID9046310 Css NA 1.076 mg/L 3compartmentss NA 95% Human Human -DTXSID9046310 Css NA 0.09598 mg/L PBTK NA 50% Human Human -DTXSID9046310 Css NA 0.6924 mg/L PBTK NA 95% Human Human -DTXSID9046310 Clint NA 137.7 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046310 Fup NA 0.0247 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046310 Vd NA 2.029 L/kg 1compartment NA NA Rat Human +DTXSID9046289 TK.Half.Life NA 2.361 hours 1compartment NA NA Rat Human +DTXSID9046289 Css NA 0.04124 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046289 Css NA 0.1706 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046289 Css NA 0.03055 mg/L PBTK NA 50% Rat Human +DTXSID9046289 Css NA 0.1142 mg/L PBTK NA 95% Rat Human +DTXSID9046310 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046310 Fup 0.0468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046310 Vd NA 2.946 L/kg 1compartment NA NA Human Human +DTXSID9046310 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9046310 TK.Half.Life NA 16.74 hours 1compartment NA NA Human Human +DTXSID9046310 Css NA 0.642 mg/L 3compartmentss NA 50% Human Human +DTXSID9046310 Css NA 4.423 mg/L 3compartmentss NA 95% Human Human +DTXSID9046310 Css NA 0.4534 mg/L PBTK NA 50% Human Human +DTXSID9046310 Css NA 2.981 mg/L PBTK NA 95% Human Human +DTXSID9046310 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046310 Fup 0.0468 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046310 Vd NA 2.294 L/kg 1compartment NA NA Rat Human DTXSID9046310 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046310 TK.Half.Life NA 1.383 hours 1compartment NA NA Rat Human -DTXSID9046310 Css NA 0.0779 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046310 Css NA 0.5113 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046310 Css NA 0.0508 mg/L PBTK NA 50% Rat Human -DTXSID9046310 Css NA 0.3146 mg/L PBTK NA 95% Rat Human -DTXSID9046318 Clint NA 30.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046318 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046318 Vd NA 10.47 L/kg 1compartment NA NA Human Human -DTXSID9046318 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9046318 TK.Half.Life NA 43.84 hours 1compartment NA NA Human Human -DTXSID9046318 Css NA 0.2694 mg/L 3compartmentss NA 50% Human Human -DTXSID9046318 Css NA 2.021 mg/L 3compartmentss NA 95% Human Human -DTXSID9046318 Css NA 0.3286 mg/L PBTK NA 50% Human Human -DTXSID9046318 Css NA 2.147 mg/L PBTK NA 95% Human Human -DTXSID9046318 Clint NA 30.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046318 Fup NA 0.0268 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046318 Vd NA 8.28 L/kg 1compartment NA NA Rat Human -DTXSID9046318 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9046318 TK.Half.Life NA 7.274 hours 1compartment NA NA Rat Human -DTXSID9046318 Css NA 0.1442 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046318 Css NA 0.8505 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046318 Css NA 0.1778 mg/L PBTK NA 50% Rat Human -DTXSID9046318 Css NA 0.8915 mg/L PBTK NA 95% Rat Human -DTXSID9046360 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046360 Fup NA 0.4439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046360 Vd NA 2.962 L/kg 1compartment NA NA Human Human -DTXSID9046360 Days.Css NA 63 Days PBTK NA NA Human Human -DTXSID9046360 TK.Half.Life NA 288.6 hours 1compartment NA NA Human Human -DTXSID9046360 Css NA 10.5 mg/L 3compartmentss NA 50% Human Human -DTXSID9046360 Css NA 31.14 mg/L 3compartmentss NA 95% Human Human -DTXSID9046360 Css NA 7.935 mg/L PBTK NA 50% Human Human -DTXSID9046360 Css NA 21.38 mg/L PBTK NA 95% Human Human -DTXSID9046360 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046360 Fup NA 0.4439 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046360 Vd NA 2.267 L/kg 1compartment NA NA Rat Human -DTXSID9046360 Days.Css NA 15 Days PBTK NA NA Rat Human -DTXSID9046360 TK.Half.Life NA 26.52 hours 1compartment NA NA Rat Human -DTXSID9046360 Css NA 2.818 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046360 Css NA 6.543 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046360 Css NA 2.051 mg/L PBTK NA 50% Rat Human -DTXSID9046360 Css NA 4.142 mg/L PBTK NA 95% Rat Human -DTXSID9046443 Clint NA 164.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046443 Fup NA 0.0618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046443 Vd NA 2.584 L/kg 1compartment NA NA Human Human -DTXSID9046443 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046443 TK.Half.Life NA 4.133 hours 1compartment NA NA Human Human -DTXSID9046443 Css NA 0.1132 mg/L 3compartmentss NA 50% Human Human -DTXSID9046443 Css NA 0.767 mg/L 3compartmentss NA 95% Human Human -DTXSID9046443 Css NA 0.07678 mg/L PBTK NA 50% Human Human -DTXSID9046443 Css NA 0.4999 mg/L PBTK NA 95% Human Human -DTXSID9046443 Clint NA 164.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046443 Fup NA 0.0618 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046443 Vd NA 1.941 L/kg 1compartment NA NA Rat Human -DTXSID9046443 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046443 TK.Half.Life NA 1.168 hours 1compartment NA NA Rat Human -DTXSID9046443 Css NA 0.0634 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046443 Css NA 0.3717 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046443 Css NA 0.04099 mg/L PBTK NA 50% Rat Human -DTXSID9046443 Css NA 0.23 mg/L PBTK NA 95% Rat Human -DTXSID9046445 Clint NA 3.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9046310 TK.Half.Life NA 3.934 hours 1compartment NA NA Rat Human +DTXSID9046310 Css NA 0.08163 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046310 Css NA 0.4838 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046310 Css NA 0.05755 mg/L PBTK NA 50% Rat Human +DTXSID9046310 Css NA 0.3225 mg/L PBTK NA 95% Rat Human +DTXSID9046360 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046360 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046360 Vd NA 1.18 L/kg 1compartment NA NA Human Human +DTXSID9046360 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046360 TK.Half.Life NA 1.341 hours 1compartment NA NA Human Human +DTXSID9046360 Css NA 0.04416 mg/L 3compartmentss NA 50% Human Human +DTXSID9046360 Css NA 0.3597 mg/L 3compartmentss NA 95% Human Human +DTXSID9046360 Css NA 0.03638 mg/L PBTK NA 50% Human Human +DTXSID9046360 Css NA 0.2614 mg/L PBTK NA 95% Human Human +DTXSID9046360 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046360 Fup 0.372 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046360 Vd NA 1.003 L/kg 1compartment NA NA Rat Human +DTXSID9046360 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046360 TK.Half.Life NA 0.5752 hours 1compartment NA NA Rat Human +DTXSID9046360 Css NA 0.002009 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046360 Css NA 0.01788 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046360 Css NA 0.001658 mg/L PBTK NA 50% Rat Human +DTXSID9046360 Css NA 0.01276 mg/L PBTK NA 95% Rat Human +DTXSID9046443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046443 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046443 Vd NA 3.051 L/kg 1compartment NA NA Human Human +DTXSID9046443 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9046443 TK.Half.Life NA 35.51 hours 1compartment NA NA Human Human +DTXSID9046443 Css NA 1.324 mg/L 3compartmentss NA 50% Human Human +DTXSID9046443 Css NA 8.418 mg/L 3compartmentss NA 95% Human Human +DTXSID9046443 Css NA 0.923 mg/L PBTK NA 50% Human Human +DTXSID9046443 Css NA 5.628 mg/L PBTK NA 95% Human Human +DTXSID9046443 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046443 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046443 Vd NA 2.291 L/kg 1compartment NA NA Rat Human +DTXSID9046443 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9046443 TK.Half.Life NA 5.554 hours 1compartment NA NA Rat Human +DTXSID9046443 Css NA 0.1705 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046443 Css NA 0.9116 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046443 Css NA 0.1178 mg/L PBTK NA 50% Rat Human +DTXSID9046443 Css NA 0.6129 mg/L PBTK NA 95% Rat Human +DTXSID9046445 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9046445 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9046445 Vd NA 0.2008 L/kg 1compartment NA NA Human Human +DTXSID9046445 Vd NA 0.2166 L/kg 1compartment NA NA Human Human DTXSID9046445 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046445 TK.Half.Life NA 9.342 hours 1compartment NA NA Human Human -DTXSID9046445 Css NA 8.55 mg/L 3compartmentss NA 50% Human Human -DTXSID9046445 Css NA 66.77 mg/L 3compartmentss NA 95% Human Human -DTXSID9046445 Css NA 5.029 mg/L PBTK NA 50% Human Human -DTXSID9046445 Css NA 38.62 mg/L PBTK NA 95% Human Human -DTXSID9046445 Clint NA 3.62 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9046445 TK.Half.Life NA 6.245 hours 1compartment NA NA Human Human +DTXSID9046445 Css NA 5.188 mg/L 3compartmentss NA 50% Human Human +DTXSID9046445 Css NA 43.75 mg/L 3compartmentss NA 95% Human Human +DTXSID9046445 Css NA 3.066 mg/L PBTK NA 50% Human Human +DTXSID9046445 Css NA 25.71 mg/L PBTK NA 95% Human Human +DTXSID9046445 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9046445 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9046445 Vd NA 0.1914 L/kg 1compartment NA NA Rat Human +DTXSID9046445 Vd NA 0.2013 L/kg 1compartment NA NA Rat Human DTXSID9046445 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046445 TK.Half.Life NA 5.394 hours 1compartment NA NA Rat Human -DTXSID9046445 Css NA 4.348 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046445 Css NA 27.07 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046445 Css NA 2.374 mg/L PBTK NA 50% Rat Human -DTXSID9046445 Css NA 14.68 mg/L PBTK NA 95% Rat Human -DTXSID9046449 Clint NA 38.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046449 Fup NA 0.0436 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046449 Vd NA 0.6274 L/kg 1compartment NA NA Human Human +DTXSID9046445 TK.Half.Life NA 3.685 hours 1compartment NA NA Rat Human +DTXSID9046445 Css NA 0.6302 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046445 Css NA 4.279 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046445 Css NA 0.357 mg/L PBTK NA 50% Rat Human +DTXSID9046445 Css NA 2.398 mg/L PBTK NA 95% Rat Human +DTXSID9046449 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046449 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046449 Vd NA 0.4204 L/kg 1compartment NA NA Human Human DTXSID9046449 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046449 TK.Half.Life NA 1.942 hours 1compartment NA NA Human Human -DTXSID9046449 Css NA 0.394 mg/L 3compartmentss NA 50% Human Human -DTXSID9046449 Css NA 3.788 mg/L 3compartmentss NA 95% Human Human -DTXSID9046449 Css NA 0.2395 mg/L PBTK NA 50% Human Human -DTXSID9046449 Css NA 2.243 mg/L PBTK NA 95% Human Human -DTXSID9046449 Clint NA 38.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046449 Fup NA 0.0436 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046449 Vd NA 0.4895 L/kg 1compartment NA NA Rat Human +DTXSID9046449 TK.Half.Life NA 1.046 hours 1compartment NA NA Human Human +DTXSID9046449 Css NA 0.2658 mg/L 3compartmentss NA 50% Human Human +DTXSID9046449 Css NA 2.16 mg/L 3compartmentss NA 95% Human Human +DTXSID9046449 Css NA 0.1706 mg/L PBTK NA 50% Human Human +DTXSID9046449 Css NA 1.325 mg/L PBTK NA 95% Human Human +DTXSID9046449 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046449 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046449 Vd NA 0.388 L/kg 1compartment NA NA Rat Human DTXSID9046449 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046449 TK.Half.Life NA 0.8979 hours 1compartment NA NA Rat Human -DTXSID9046449 Css NA 0.2274 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046449 Css NA 1.637 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046449 Css NA 0.13 mg/L PBTK NA 50% Rat Human -DTXSID9046449 Css NA 0.9079 mg/L PBTK NA 95% Rat Human -DTXSID9046491 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9046449 TK.Half.Life NA 0.5705 hours 1compartment NA NA Rat Human +DTXSID9046449 Css NA 0.03432 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046449 Css NA 0.2148 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046449 Css NA 0.0214 mg/L PBTK NA 50% Rat Human +DTXSID9046449 Css NA 0.1268 mg/L PBTK NA 95% Rat Human +DTXSID9046491 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9046491 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9046491 Vd NA 0.4649 L/kg 1compartment NA NA Human Human +DTXSID9046491 Vd NA 0.4553 L/kg 1compartment NA NA Human Human DTXSID9046491 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046491 TK.Half.Life NA 3.58 hours 1compartment NA NA Human Human -DTXSID9046491 Css NA 1.078 mg/L 3compartmentss NA 50% Human Human -DTXSID9046491 Css NA 5.801 mg/L 3compartmentss NA 95% Human Human -DTXSID9046491 Css NA 0.7945 mg/L PBTK NA 50% Human Human -DTXSID9046491 Css NA 3.612 mg/L PBTK NA 95% Human Human -DTXSID9046491 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9046491 TK.Half.Life NA 3.506 hours 1compartment NA NA Human Human +DTXSID9046491 Css NA 0.9335 mg/L 3compartmentss NA 50% Human Human +DTXSID9046491 Css NA 5.157 mg/L 3compartmentss NA 95% Human Human +DTXSID9046491 Css NA 0.685 mg/L PBTK NA 50% Human Human +DTXSID9046491 Css NA 3.254 mg/L PBTK NA 95% Human Human +DTXSID9046491 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9046491 Fup 0.84 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9046491 Vd NA 0.4868 L/kg 1compartment NA NA Rat Human +DTXSID9046491 Vd NA 0.4784 L/kg 1compartment NA NA Rat Human DTXSID9046491 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046491 TK.Half.Life NA 1.278 hours 1compartment NA NA Rat Human -DTXSID9046491 Css NA 0.2798 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046491 Css NA 1.483 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046491 Css NA 0.1976 mg/L PBTK NA 50% Rat Human -DTXSID9046491 Css NA 0.8578 mg/L PBTK NA 95% Rat Human -DTXSID9046495 Clint NA 60.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9046491 TK.Half.Life NA 1.256 hours 1compartment NA NA Rat Human +DTXSID9046491 Css NA 0.02427 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046491 Css NA 0.1601 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046491 Css NA 0.01721 mg/L PBTK NA 50% Rat Human +DTXSID9046491 Css NA 0.09824 mg/L PBTK NA 95% Rat Human +DTXSID9046495 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9046495 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9046495 Vd NA 0.4925 L/kg 1compartment NA NA Human Human +DTXSID9046495 Vd NA 0.2768 L/kg 1compartment NA NA Human Human DTXSID9046495 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046495 TK.Half.Life NA 0.7812 hours 1compartment NA NA Human Human -DTXSID9046495 Css NA 0.1234 mg/L 3compartmentss NA 50% Human Human -DTXSID9046495 Css NA 1.034 mg/L 3compartmentss NA 95% Human Human -DTXSID9046495 Css NA 0.07612 mg/L PBTK NA 50% Human Human -DTXSID9046495 Css NA 0.6147 mg/L PBTK NA 95% Human Human -DTXSID9046495 Clint NA 60.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9046495 TK.Half.Life NA 1.96 hours 1compartment NA NA Human Human +DTXSID9046495 Css NA 1.072 mg/L 3compartmentss NA 50% Human Human +DTXSID9046495 Css NA 7.225 mg/L 3compartmentss NA 95% Human Human +DTXSID9046495 Css NA 0.6499 mg/L PBTK NA 50% Human Human +DTXSID9046495 Css NA 4.255 mg/L PBTK NA 95% Human Human +DTXSID9046495 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9046495 Fup 0.09 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9046495 Vd NA 0.4532 L/kg 1compartment NA NA Rat Human +DTXSID9046495 Vd NA 0.2639 L/kg 1compartment NA NA Rat Human DTXSID9046495 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046495 TK.Half.Life NA 0.3914 hours 1compartment NA NA Rat Human -DTXSID9046495 Css NA 0.0696 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046495 Css NA 0.4743 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046495 Css NA 0.04064 mg/L PBTK NA 50% Rat Human -DTXSID9046495 Css NA 0.2687 mg/L PBTK NA 95% Rat Human -DTXSID9046497 Clint NA 5.495 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046497 Fup NA 0.0295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046497 Vd NA 0.7519 L/kg 1compartment NA NA Human Human -DTXSID9046497 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9046497 TK.Half.Life NA 16.08 hours 1compartment NA NA Human Human -DTXSID9046497 Css NA 3.762 mg/L 3compartmentss NA 50% Human Human -DTXSID9046497 Css NA 29.89 mg/L 3compartmentss NA 95% Human Human -DTXSID9046497 Css NA 2.287 mg/L PBTK NA 50% Human Human -DTXSID9046497 Css NA 17.45 mg/L PBTK NA 95% Human Human -DTXSID9046497 Clint NA 5.495 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046497 Fup NA 0.0295 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046497 Vd NA 0.5736 L/kg 1compartment NA NA Rat Human +DTXSID9046495 TK.Half.Life NA 1.142 hours 1compartment NA NA Rat Human +DTXSID9046495 Css NA 0.1308 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046495 Css NA 0.6691 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046495 Css NA 0.0771 mg/L PBTK NA 50% Rat Human +DTXSID9046495 Css NA 0.3827 mg/L PBTK NA 95% Rat Human +DTXSID9046497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046497 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046497 Vd NA 1.015 L/kg 1compartment NA NA Human Human +DTXSID9046497 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046497 TK.Half.Life NA 2.261 hours 1compartment NA NA Human Human +DTXSID9046497 Css NA 0.184 mg/L 3compartmentss NA 50% Human Human +DTXSID9046497 Css NA 1.582 mg/L 3compartmentss NA 95% Human Human +DTXSID9046497 Css NA 0.1217 mg/L PBTK NA 50% Human Human +DTXSID9046497 Css NA 0.9767 mg/L PBTK NA 95% Human Human +DTXSID9046497 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046497 Fup 0.128 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046497 Vd NA 0.8083 L/kg 1compartment NA NA Rat Human DTXSID9046497 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046497 TK.Half.Life NA 7.279 hours 1compartment NA NA Rat Human -DTXSID9046497 Css NA 1.991 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046497 Css NA 12.8 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046497 Css NA 1.13 mg/L PBTK NA 50% Rat Human -DTXSID9046497 Css NA 7.026 mg/L PBTK NA 95% Rat Human -DTXSID9046499 Clint NA 41.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046499 Fup NA 0.1248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046499 Vd NA 2.817 L/kg 1compartment NA NA Human Human +DTXSID9046497 TK.Half.Life NA 0.9843 hours 1compartment NA NA Rat Human +DTXSID9046497 Css NA 0.008945 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046497 Css NA 0.07806 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046497 Css NA 0.005776 mg/L PBTK NA 50% Rat Human +DTXSID9046497 Css NA 0.04674 mg/L PBTK NA 95% Rat Human +DTXSID9046499 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046499 Fup 0.0983 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046499 Vd NA 2.055 L/kg 1compartment NA NA Human Human DTXSID9046499 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046499 TK.Half.Life NA 2.696 hours 1compartment NA NA Human Human -DTXSID9046499 Css NA 0.04684 mg/L 3compartmentss NA 50% Human Human -DTXSID9046499 Css NA 0.5015 mg/L 3compartmentss NA 95% Human Human -DTXSID9046499 Css NA 0.04548 mg/L PBTK NA 50% Human Human -DTXSID9046499 Css NA 0.3807 mg/L PBTK NA 95% Human Human -DTXSID9046499 Clint NA 41.46 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046499 Fup NA 0.1248 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046499 Vd NA 2.81 L/kg 1compartment NA NA Rat Human +DTXSID9046499 TK.Half.Life NA 9.414 hours 1compartment NA NA Human Human +DTXSID9046499 Css NA 0.4935 mg/L 3compartmentss NA 50% Human Human +DTXSID9046499 Css NA 4.287 mg/L 3compartmentss NA 95% Human Human +DTXSID9046499 Css NA 0.4106 mg/L PBTK NA 50% Human Human +DTXSID9046499 Css NA 2.979 mg/L PBTK NA 95% Human Human +DTXSID9046499 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046499 Fup 0.0983 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046499 Vd NA 2.041 L/kg 1compartment NA NA Rat Human DTXSID9046499 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046499 TK.Half.Life NA 1.459 hours 1compartment NA NA Rat Human -DTXSID9046499 Css NA 0.02609 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046499 Css NA 0.2074 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046499 Css NA 0.0245 mg/L PBTK NA 50% Rat Human -DTXSID9046499 Css NA 0.1537 mg/L PBTK NA 95% Rat Human -DTXSID9046520 Clint NA 0.0724 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046520 Fup NA 0.8727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046520 Vd NA 0.6525 L/kg 1compartment NA NA Human Human +DTXSID9046499 TK.Half.Life NA 5.805 hours 1compartment NA NA Rat Human +DTXSID9046499 Css NA 0.06039 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046499 Css NA 0.3972 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046499 Css NA 0.05032 mg/L PBTK NA 50% Rat Human +DTXSID9046499 Css NA 0.2654 mg/L PBTK NA 95% Rat Human +DTXSID9046520 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046520 Fup 0.749 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046520 Vd NA 0.5451 L/kg 1compartment NA NA Human Human DTXSID9046520 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046520 TK.Half.Life NA 4.327 hours 1compartment NA NA Human Human -DTXSID9046520 Css NA 0.88 mg/L 3compartmentss NA 50% Human Human -DTXSID9046520 Css NA 4.908 mg/L 3compartmentss NA 95% Human Human -DTXSID9046520 Css NA 0.6836 mg/L PBTK NA 50% Human Human -DTXSID9046520 Css NA 3.126 mg/L PBTK NA 95% Human Human -DTXSID9046520 Clint NA 0.0724 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046520 Fup NA 0.8727 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046520 Vd NA 0.6703 L/kg 1compartment NA NA Rat Human +DTXSID9046520 TK.Half.Life NA 4.709 hours 1compartment NA NA Human Human +DTXSID9046520 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human +DTXSID9046520 Css NA 6.445 mg/L 3compartmentss NA 95% Human Human +DTXSID9046520 Css NA 0.8238 mg/L PBTK NA 50% Human Human +DTXSID9046520 Css NA 4.029 mg/L PBTK NA 95% Human Human +DTXSID9046520 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046520 Fup 0.749 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046520 Vd NA 0.5664 L/kg 1compartment NA NA Rat Human DTXSID9046520 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046520 TK.Half.Life NA 1.601 hours 1compartment NA NA Rat Human -DTXSID9046520 Css NA 0.2421 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046520 Css NA 1.289 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046520 Css NA 0.1814 mg/L PBTK NA 50% Rat Human -DTXSID9046520 Css NA 0.7598 mg/L PBTK NA 95% Rat Human -DTXSID9046524 Clint NA 9.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046524 Fup NA 0.6495 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046524 Vd NA 0.7995 L/kg 1compartment NA NA Human Human +DTXSID9046520 TK.Half.Life NA 1.667 hours 1compartment NA NA Rat Human +DTXSID9046520 Css NA 0.06574 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046520 Css NA 0.3796 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046520 Css NA 0.04902 mg/L PBTK NA 50% Rat Human +DTXSID9046520 Css NA 0.2276 mg/L PBTK NA 95% Rat Human +DTXSID9046524 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046524 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046524 Vd NA 0.7529 L/kg 1compartment NA NA Human Human DTXSID9046524 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046524 TK.Half.Life NA 0.9154 hours 1compartment NA NA Human Human -DTXSID9046524 Css NA 0.07181 mg/L 3compartmentss NA 50% Human Human -DTXSID9046524 Css NA 0.731 mg/L 3compartmentss NA 95% Human Human -DTXSID9046524 Css NA 0.05791 mg/L PBTK NA 50% Human Human -DTXSID9046524 Css NA 0.49 mg/L PBTK NA 95% Human Human -DTXSID9046524 Clint NA 9.68 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046524 Fup NA 0.6495 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046524 Vd NA 0.7934 L/kg 1compartment NA NA Rat Human +DTXSID9046524 TK.Half.Life NA 1.143 hours 1compartment NA NA Human Human +DTXSID9046524 Css NA 0.1136 mg/L 3compartmentss NA 50% Human Human +DTXSID9046524 Css NA 1.012 mg/L 3compartmentss NA 95% Human Human +DTXSID9046524 Css NA 0.0908 mg/L PBTK NA 50% Human Human +DTXSID9046524 Css NA 0.6673 mg/L PBTK NA 95% Human Human +DTXSID9046524 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046524 Fup 0.587 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046524 Vd NA 0.7465 L/kg 1compartment NA NA Rat Human DTXSID9046524 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046524 TK.Half.Life NA 0.4761 hours 1compartment NA NA Rat Human -DTXSID9046524 Css NA 0.0352 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046524 Css NA 0.3019 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046524 Css NA 0.0281 mg/L PBTK NA 50% Rat Human -DTXSID9046524 Css NA 0.1824 mg/L PBTK NA 95% Rat Human -DTXSID9046526 Clint NA 17.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046526 Fup NA 0.616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046526 Vd NA 1.235 L/kg 1compartment NA NA Human Human +DTXSID9046524 TK.Half.Life NA 0.6123 hours 1compartment NA NA Rat Human +DTXSID9046524 Css NA 0.01295 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046524 Css NA 0.1029 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046524 Css NA 0.01036 mg/L PBTK NA 50% Rat Human +DTXSID9046524 Css NA 0.06337 mg/L PBTK NA 95% Rat Human +DTXSID9046526 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046526 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046526 Vd NA 0.9754 L/kg 1compartment NA NA Human Human DTXSID9046526 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046526 TK.Half.Life NA 1.152 hours 1compartment NA NA Human Human -DTXSID9046526 Css NA 0.04208 mg/L 3compartmentss NA 50% Human Human -DTXSID9046526 Css NA 0.4425 mg/L 3compartmentss NA 95% Human Human -DTXSID9046526 Css NA 0.0357 mg/L PBTK NA 50% Human Human -DTXSID9046526 Css NA 0.3139 mg/L PBTK NA 95% Human Human -DTXSID9046526 Clint NA 17.82 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046526 Fup NA 0.616 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046526 Vd NA 1.109 L/kg 1compartment NA NA Rat Human +DTXSID9046526 TK.Half.Life NA 1.07 hours 1compartment NA NA Human Human +DTXSID9046526 Css NA 0.04702 mg/L 3compartmentss NA 50% Human Human +DTXSID9046526 Css NA 0.3758 mg/L 3compartmentss NA 95% Human Human +DTXSID9046526 Css NA 0.03682 mg/L PBTK NA 50% Human Human +DTXSID9046526 Css NA 0.2623 mg/L PBTK NA 95% Human Human +DTXSID9046526 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046526 Fup 0.409 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046526 Vd NA 0.8725 L/kg 1compartment NA NA Rat Human DTXSID9046526 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046526 TK.Half.Life NA 0.5119 hours 1compartment NA NA Rat Human -DTXSID9046526 Css NA 0.02132 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046526 Css NA 0.1975 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046526 Css NA 0.01774 mg/L PBTK NA 50% Rat Human -DTXSID9046526 Css NA 0.1279 mg/L PBTK NA 95% Rat Human -DTXSID9046528 Clint NA 222.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046528 Fup NA 0.2306 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046528 Vd NA 4.579 L/kg 1compartment NA NA Human Human -DTXSID9046528 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046528 TK.Half.Life NA 2.606 hours 1compartment NA NA Human Human -DTXSID9046528 Css NA 0.003184 mg/L 3compartmentss NA 50% Human Human -DTXSID9046528 Css NA 0.02195 mg/L 3compartmentss NA 95% Human Human -DTXSID9046528 Css NA 0.003294 mg/L PBTK NA 50% Human Human -DTXSID9046528 Css NA 0.02064 mg/L PBTK NA 95% Human Human -DTXSID9046528 Clint NA 222.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046528 Fup NA 0.2306 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046528 Vd NA 4.03 L/kg 1compartment NA NA Rat Human -DTXSID9046528 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046528 TK.Half.Life NA 0.9693 hours 1compartment NA NA Rat Human -DTXSID9046528 Css NA 0.001705 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046528 Css NA 0.01042 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046528 Css NA 0.001754 mg/L PBTK NA 50% Rat Human -DTXSID9046528 Css NA 0.009491 mg/L PBTK NA 95% Rat Human -DTXSID9046570 Clint NA 6.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046570 Fup NA 0.3438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046570 Vd NA 0.6053 L/kg 1compartment NA NA Human Human +DTXSID9046526 TK.Half.Life NA 0.4861 hours 1compartment NA NA Rat Human +DTXSID9046526 Css NA 0.005844 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046526 Css NA 0.03861 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046526 Css NA 0.00455 mg/L PBTK NA 50% Rat Human +DTXSID9046526 Css NA 0.0261 mg/L PBTK NA 95% Rat Human +DTXSID9046570 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046570 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046570 Vd NA 0.5332 L/kg 1compartment NA NA Human Human DTXSID9046570 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046570 TK.Half.Life NA 1.416 hours 1compartment NA NA Human Human -DTXSID9046570 Css NA 0.2054 mg/L 3compartmentss NA 50% Human Human -DTXSID9046570 Css NA 1.316 mg/L 3compartmentss NA 95% Human Human -DTXSID9046570 Css NA 0.1477 mg/L PBTK NA 50% Human Human -DTXSID9046570 Css NA 0.858 mg/L PBTK NA 95% Human Human -DTXSID9046570 Clint NA 6.074 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046570 Fup NA 0.3438 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046570 Vd NA 0.5736 L/kg 1compartment NA NA Rat Human +DTXSID9046570 TK.Half.Life NA 1.474 hours 1compartment NA NA Human Human +DTXSID9046570 Css NA 0.2549 mg/L 3compartmentss NA 50% Human Human +DTXSID9046570 Css NA 1.543 mg/L 3compartmentss NA 95% Human Human +DTXSID9046570 Css NA 0.1759 mg/L PBTK NA 50% Human Human +DTXSID9046570 Css NA 0.99 mg/L PBTK NA 95% Human Human +DTXSID9046570 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046570 Fup 0.272 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046570 Vd NA 0.5047 L/kg 1compartment NA NA Rat Human DTXSID9046570 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046570 TK.Half.Life NA 0.7533 hours 1compartment NA NA Rat Human -DTXSID9046570 Css NA 0.1062 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046570 Css NA 0.4854 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046570 Css NA 0.0727 mg/L PBTK NA 50% Rat Human -DTXSID9046570 Css NA 0.297 mg/L PBTK NA 95% Rat Human +DTXSID9046570 TK.Half.Life NA 0.7976 hours 1compartment NA NA Rat Human +DTXSID9046570 Css NA 0.03051 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046570 Css NA 0.1354 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046570 Css NA 0.02073 mg/L PBTK NA 50% Rat Human +DTXSID9046570 Css NA 0.08424 mg/L PBTK NA 95% Rat Human DTXSID9046572 Clint NA 0.4493 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9046572 Fup NA 0.5851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046572 Vd NA 0.6221 L/kg 1compartment NA NA Human Human +DTXSID9046572 Vd NA 0.6288 L/kg 1compartment NA NA Human Human DTXSID9046572 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046572 TK.Half.Life NA 4.03 hours 1compartment NA NA Human Human -DTXSID9046572 Css NA 0.7231 mg/L 3compartmentss NA 50% Human Human -DTXSID9046572 Css NA 4.947 mg/L 3compartmentss NA 95% Human Human -DTXSID9046572 Css NA 0.5641 mg/L PBTK NA 50% Human Human -DTXSID9046572 Css NA 3.087 mg/L PBTK NA 95% Human Human +DTXSID9046572 TK.Half.Life NA 4.073 hours 1compartment NA NA Human Human +DTXSID9046572 Css NA 0.6096 mg/L 3compartmentss NA 50% Human Human +DTXSID9046572 Css NA 4.165 mg/L 3compartmentss NA 95% Human Human +DTXSID9046572 Css NA 0.4772 mg/L PBTK NA 50% Human Human +DTXSID9046572 Css NA 2.624 mg/L PBTK NA 95% Human Human DTXSID9046572 Clint NA 0.4493 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9046572 Fup NA 0.5851 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046572 Vd NA 0.6392 L/kg 1compartment NA NA Rat Human +DTXSID9046572 Vd NA 0.6448 L/kg 1compartment NA NA Rat Human DTXSID9046572 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046572 TK.Half.Life NA 1.784 hours 1compartment NA NA Rat Human -DTXSID9046572 Css NA 0.2499 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046572 Css NA 1.613 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046572 Css NA 0.1869 mg/L PBTK NA 50% Rat Human -DTXSID9046572 Css NA 0.9402 mg/L PBTK NA 95% Rat Human +DTXSID9046572 TK.Half.Life NA 1.8 hours 1compartment NA NA Rat Human +DTXSID9046572 Css NA 0.0151 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046572 Css NA 0.1323 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046572 Css NA 0.01141 mg/L PBTK NA 50% Rat Human +DTXSID9046572 Css NA 0.08205 mg/L PBTK NA 95% Rat Human DTXSID9046574 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9046574 Fup NA 0.7461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046574 Vd NA 0.6539 L/kg 1compartment NA NA Human Human +DTXSID9046574 Vd NA 0.6649 L/kg 1compartment NA NA Human Human DTXSID9046574 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046574 TK.Half.Life NA 5.672 hours 1compartment NA NA Human Human -DTXSID9046574 Css NA 1.052 mg/L 3compartmentss NA 50% Human Human -DTXSID9046574 Css NA 6.35 mg/L 3compartmentss NA 95% Human Human -DTXSID9046574 Css NA 0.8476 mg/L PBTK NA 50% Human Human -DTXSID9046574 Css NA 4.014 mg/L PBTK NA 95% Human Human +DTXSID9046574 TK.Half.Life NA 5.767 hours 1compartment NA NA Human Human +DTXSID9046574 Css NA 0.8994 mg/L 3compartmentss NA 50% Human Human +DTXSID9046574 Css NA 5.487 mg/L 3compartmentss NA 95% Human Human +DTXSID9046574 Css NA 0.7292 mg/L PBTK NA 50% Human Human +DTXSID9046574 Css NA 3.477 mg/L PBTK NA 95% Human Human DTXSID9046574 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9046574 Fup NA 0.7461 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046574 Vd NA 0.6846 L/kg 1compartment NA NA Rat Human +DTXSID9046574 Vd NA 0.6943 L/kg 1compartment NA NA Rat Human DTXSID9046574 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046574 TK.Half.Life NA 2.024 hours 1compartment NA NA Rat Human -DTXSID9046574 Css NA 0.275 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046574 Css NA 1.67 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046574 Css NA 0.2126 mg/L PBTK NA 50% Rat Human -DTXSID9046574 Css NA 0.9854 mg/L PBTK NA 95% Rat Human -DTXSID9046576 Clint NA 25.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046576 Fup NA 0.4429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046576 Vd NA 3.138 L/kg 1compartment NA NA Human Human -DTXSID9046576 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID9046576 TK.Half.Life NA 65.08 hours 1compartment NA NA Human Human -DTXSID9046576 Css NA 2.44 mg/L 3compartmentss NA 50% Human Human -DTXSID9046576 Css NA 15.23 mg/L 3compartmentss NA 95% Human Human -DTXSID9046576 Css NA 1.696 mg/L PBTK NA 50% Human Human -DTXSID9046576 Css NA 10.27 mg/L PBTK NA 95% Human Human -DTXSID9046576 Clint NA 25.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046576 Fup NA 0.4429 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046576 Vd NA 2.353 L/kg 1compartment NA NA Rat Human -DTXSID9046576 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID9046576 TK.Half.Life NA 8.704 hours 1compartment NA NA Rat Human -DTXSID9046576 Css NA 1.386 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046576 Css NA 7.198 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046576 Css NA 0.9232 mg/L PBTK NA 50% Rat Human -DTXSID9046576 Css NA 4.595 mg/L PBTK NA 95% Rat Human -DTXSID9046578 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046578 Fup NA 0.013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046578 Vd NA 0.5127 L/kg 1compartment NA NA Human Human -DTXSID9046578 Days.Css NA 65 Days PBTK NA NA Human Human -DTXSID9046578 TK.Half.Life NA 266.2 hours 1compartment NA NA Human Human -DTXSID9046578 Css NA 87.82 mg/L 3compartmentss NA 50% Human Human -DTXSID9046578 Css NA 542.8 mg/L 3compartmentss NA 95% Human Human -DTXSID9046578 Css NA 52.1 mg/L PBTK NA 50% Human Human -DTXSID9046578 Css NA 310.8 mg/L PBTK NA 95% Human Human -DTXSID9046578 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046578 Fup NA 0.013 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046578 Vd NA 0.3926 L/kg 1compartment NA NA Rat Human -DTXSID9046578 Days.Css NA 13 Days PBTK NA NA Rat Human -DTXSID9046578 TK.Half.Life NA 67.23 hours 1compartment NA NA Rat Human -DTXSID9046578 Css NA 25.24 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046578 Css NA 130.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046578 Css NA 13.94 mg/L PBTK NA 50% Rat Human -DTXSID9046578 Css NA 70.91 mg/L PBTK NA 95% Rat Human +DTXSID9046574 TK.Half.Life NA 2.052 hours 1compartment NA NA Rat Human +DTXSID9046574 Css NA 0.01708 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046574 Css NA 0.1382 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046574 Css NA 0.01328 mg/L PBTK NA 50% Rat Human +DTXSID9046574 Css NA 0.08763 mg/L PBTK NA 95% Rat Human +DTXSID9046576 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046576 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046576 Vd NA 0.4486 L/kg 1compartment NA NA Human Human +DTXSID9046576 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046576 TK.Half.Life NA 1.845 hours 1compartment NA NA Human Human +DTXSID9046576 Css NA 0.468 mg/L 3compartmentss NA 50% Human Human +DTXSID9046576 Css NA 2.79 mg/L 3compartmentss NA 95% Human Human +DTXSID9046576 Css NA 0.3057 mg/L PBTK NA 50% Human Human +DTXSID9046576 Css NA 1.737 mg/L PBTK NA 95% Human Human +DTXSID9046576 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046576 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046576 Vd NA 0.4253 L/kg 1compartment NA NA Rat Human +DTXSID9046576 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046576 TK.Half.Life NA 1.036 hours 1compartment NA NA Rat Human +DTXSID9046576 Css NA 0.05626 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046576 Css NA 0.2488 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046576 Css NA 0.03614 mg/L PBTK NA 50% Rat Human +DTXSID9046576 Css NA 0.1491 mg/L PBTK NA 95% Rat Human +DTXSID9046578 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046578 Fup 0.07 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046578 Vd NA 0.2044 L/kg 1compartment NA NA Human Human +DTXSID9046578 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046578 TK.Half.Life NA 1.748 hours 1compartment NA NA Human Human +DTXSID9046578 Css NA 1.184 mg/L 3compartmentss NA 50% Human Human +DTXSID9046578 Css NA 7.616 mg/L 3compartmentss NA 95% Human Human +DTXSID9046578 Css NA 0.7044 mg/L PBTK NA 50% Human Human +DTXSID9046578 Css NA 4.52 mg/L PBTK NA 95% Human Human +DTXSID9046578 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046578 Fup 0.07 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046578 Vd NA 0.2087 L/kg 1compartment NA NA Rat Human +DTXSID9046578 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046578 TK.Half.Life NA 1.105 hours 1compartment NA NA Rat Human +DTXSID9046578 Css NA 0.04196 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046578 Css NA 0.3064 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046578 Css NA 0.0236 mg/L PBTK NA 50% Rat Human +DTXSID9046578 Css NA 0.1732 mg/L PBTK NA 95% Rat Human +DTXSID90465947 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90465947 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90465947 Vd NA 0.5026 L/kg 1compartment NA NA Human Human +DTXSID90465947 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90465947 TK.Half.Life NA 3.1 hours 1compartment NA NA Human Human +DTXSID90465947 Css NA 0.8312 mg/L 3compartmentss NA 50% Human Human +DTXSID90465947 Css NA 5.992 mg/L 3compartmentss NA 95% Human Human +DTXSID90465947 Css NA 0.522 mg/L PBTK NA 50% Human Human +DTXSID90465947 Css NA 3.616 mg/L PBTK NA 95% Human Human +DTXSID90465947 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90465947 Fup 0.104 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90465947 Vd NA 0.4395 L/kg 1compartment NA NA Rat Human +DTXSID90465947 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90465947 TK.Half.Life NA 1.631 hours 1compartment NA NA Rat Human +DTXSID90465947 Css NA 0.0775 mg/L 3compartmentss NA 50% Rat Human +DTXSID90465947 Css NA 0.4294 mg/L 3compartmentss NA 95% Rat Human +DTXSID90465947 Css NA 0.04774 mg/L PBTK NA 50% Rat Human +DTXSID90465947 Css NA 0.2506 mg/L PBTK NA 95% Rat Human DTXSID9046601 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9046601 Fup NA 0.7675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046601 Vd NA 0.612 L/kg 1compartment NA NA Human Human +DTXSID9046601 Vd NA 0.5621 L/kg 1compartment NA NA Human Human DTXSID9046601 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046601 TK.Half.Life NA 5.157 hours 1compartment NA NA Human Human -DTXSID9046601 Css NA 1.046 mg/L 3compartmentss NA 50% Human Human -DTXSID9046601 Css NA 6.513 mg/L 3compartmentss NA 95% Human Human -DTXSID9046601 Css NA 0.8332 mg/L PBTK NA 50% Human Human -DTXSID9046601 Css NA 4.156 mg/L PBTK NA 95% Human Human +DTXSID9046601 TK.Half.Life NA 4.738 hours 1compartment NA NA Human Human +DTXSID9046601 Css NA 0.91 mg/L 3compartmentss NA 50% Human Human +DTXSID9046601 Css NA 5.711 mg/L 3compartmentss NA 95% Human Human +DTXSID9046601 Css NA 0.7116 mg/L PBTK NA 50% Human Human +DTXSID9046601 Css NA 3.577 mg/L PBTK NA 95% Human Human DTXSID9046601 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9046601 Fup NA 0.7675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046601 Vd NA 0.6488 L/kg 1compartment NA NA Rat Human +DTXSID9046601 Vd NA 0.6075 L/kg 1compartment NA NA Rat Human DTXSID9046601 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046601 TK.Half.Life NA 1.864 hours 1compartment NA NA Rat Human -DTXSID9046601 Css NA 0.2704 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046601 Css NA 1.656 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046601 Css NA 0.2077 mg/L PBTK NA 50% Rat Human -DTXSID9046601 Css NA 0.9745 mg/L PBTK NA 95% Rat Human +DTXSID9046601 TK.Half.Life NA 1.745 hours 1compartment NA NA Rat Human +DTXSID9046601 Css NA 0.0172 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046601 Css NA 0.1318 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046601 Css NA 0.01282 mg/L PBTK NA 50% Rat Human +DTXSID9046601 Css NA 0.08387 mg/L PBTK NA 95% Rat Human DTXSID9046603 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9046603 Fup NA 0.7441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046603 Vd NA 0.5741 L/kg 1compartment NA NA Human Human -DTXSID9046603 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046603 TK.Half.Life NA 4.99 hours 1compartment NA NA Human Human -DTXSID9046603 Css NA 1.084 mg/L 3compartmentss NA 50% Human Human -DTXSID9046603 Css NA 6.544 mg/L 3compartmentss NA 95% Human Human -DTXSID9046603 Css NA 0.8514 mg/L PBTK NA 50% Human Human -DTXSID9046603 Css NA 4.128 mg/L PBTK NA 95% Human Human +DTXSID9046603 Vd NA 2.531 L/kg 1compartment NA NA Human Human +DTXSID9046603 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9046603 TK.Half.Life NA 22.01 hours 1compartment NA NA Human Human +DTXSID9046603 Css NA 0.6238 mg/L 3compartmentss NA 50% Human Human +DTXSID9046603 Css NA 4.988 mg/L 3compartmentss NA 95% Human Human +DTXSID9046603 Css NA 0.7262 mg/L PBTK NA 50% Human Human +DTXSID9046603 Css NA 3.643 mg/L PBTK NA 95% Human Human DTXSID9046603 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9046603 Fup NA 0.7441 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046603 Vd NA 0.6175 L/kg 1compartment NA NA Rat Human +DTXSID9046603 Vd NA 2.511 L/kg 1compartment NA NA Rat Human DTXSID9046603 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046603 TK.Half.Life NA 1.83 hours 1compartment NA NA Rat Human -DTXSID9046603 Css NA 0.2814 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046603 Css NA 1.729 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046603 Css NA 0.2123 mg/L PBTK NA 50% Rat Human -DTXSID9046603 Css NA 1.012 mg/L PBTK NA 95% Rat Human -DTXSID9046605 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046605 Fup NA 0.7904 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046605 Vd NA 0.5763 L/kg 1compartment NA NA Human Human -DTXSID9046605 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046605 TK.Half.Life NA 4.718 hours 1compartment NA NA Human Human -DTXSID9046605 Css NA 1.058 mg/L 3compartmentss NA 50% Human Human -DTXSID9046605 Css NA 5.992 mg/L 3compartmentss NA 95% Human Human -DTXSID9046605 Css NA 0.8268 mg/L PBTK NA 50% Human Human -DTXSID9046605 Css NA 3.793 mg/L PBTK NA 95% Human Human -DTXSID9046605 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046605 Fup NA 0.7904 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046605 Vd NA 0.6261 L/kg 1compartment NA NA Rat Human -DTXSID9046605 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046605 TK.Half.Life NA 1.746 hours 1compartment NA NA Rat Human -DTXSID9046605 Css NA 0.267 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046605 Css NA 1.591 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046605 Css NA 0.2027 mg/L PBTK NA 50% Rat Human -DTXSID9046605 Css NA 0.9348 mg/L PBTK NA 95% Rat Human -DTXSID9046607 Clint NA 0.8663 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046607 Fup NA 0.4669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046607 Vd NA 0.6233 L/kg 1compartment NA NA Human Human +DTXSID9046603 TK.Half.Life NA 7.441 hours 1compartment NA NA Rat Human +DTXSID9046603 Css NA 0.01172 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046603 Css NA 0.1145 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046603 Css NA 0.01332 mg/L PBTK NA 50% Rat Human +DTXSID9046603 Css NA 0.08479 mg/L PBTK NA 95% Rat Human +DTXSID9046607 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046607 Fup 0.572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046607 Vd NA 0.614 L/kg 1compartment NA NA Human Human DTXSID9046607 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046607 TK.Half.Life NA 3.637 hours 1compartment NA NA Human Human -DTXSID9046607 Css NA 0.5992 mg/L 3compartmentss NA 50% Human Human -DTXSID9046607 Css NA 3.344 mg/L 3compartmentss NA 95% Human Human -DTXSID9046607 Css NA 0.4711 mg/L PBTK NA 50% Human Human -DTXSID9046607 Css NA 2.2 mg/L PBTK NA 95% Human Human -DTXSID9046607 Clint NA 0.8663 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046607 Fup NA 0.4669 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046607 Vd NA 0.6357 L/kg 1compartment NA NA Rat Human +DTXSID9046607 TK.Half.Life NA 6.945 hours 1compartment NA NA Human Human +DTXSID9046607 Css NA 1.103 mg/L 3compartmentss NA 50% Human Human +DTXSID9046607 Css NA 7.702 mg/L 3compartmentss NA 95% Human Human +DTXSID9046607 Css NA 0.8692 mg/L PBTK NA 50% Human Human +DTXSID9046607 Css NA 4.872 mg/L PBTK NA 95% Human Human +DTXSID9046607 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046607 Fup 0.572 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046607 Vd NA 0.6354 L/kg 1compartment NA NA Rat Human DTXSID9046607 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046607 TK.Half.Life NA 1.781 hours 1compartment NA NA Rat Human -DTXSID9046607 Css NA 0.2354 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046607 Css NA 1.089 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046607 Css NA 0.1768 mg/L PBTK NA 50% Rat Human -DTXSID9046607 Css NA 0.6548 mg/L PBTK NA 95% Rat Human -DTXSID9046609 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046609 Fup NA 0.7509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046609 Vd NA 2.722 L/kg 1compartment NA NA Human Human -DTXSID9046609 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9046609 TK.Half.Life NA 23.46 hours 1compartment NA NA Human Human -DTXSID9046609 Css NA 0.6968 mg/L 3compartmentss NA 50% Human Human -DTXSID9046609 Css NA 5.548 mg/L 3compartmentss NA 95% Human Human -DTXSID9046609 Css NA 0.8403 mg/L PBTK NA 50% Human Human -DTXSID9046609 Css NA 4.113 mg/L PBTK NA 95% Human Human -DTXSID9046609 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046609 Fup NA 0.7509 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046609 Vd NA 2.719 L/kg 1compartment NA NA Rat Human +DTXSID9046607 TK.Half.Life NA 2.449 hours 1compartment NA NA Rat Human +DTXSID9046607 Css NA 0.02104 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046607 Css NA 0.1873 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046607 Css NA 0.01592 mg/L PBTK NA 50% Rat Human +DTXSID9046607 Css NA 0.1159 mg/L PBTK NA 95% Rat Human +DTXSID9046609 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046609 Fup 0.516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046609 Vd NA 0.4619 L/kg 1compartment NA NA Human Human +DTXSID9046609 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046609 TK.Half.Life NA 5.796 hours 1compartment NA NA Human Human +DTXSID9046609 Css NA 1.259 mg/L 3compartmentss NA 50% Human Human +DTXSID9046609 Css NA 6.521 mg/L 3compartmentss NA 95% Human Human +DTXSID9046609 Css NA 0.9222 mg/L PBTK NA 50% Human Human +DTXSID9046609 Css NA 4.096 mg/L PBTK NA 95% Human Human +DTXSID9046609 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046609 Fup 0.516 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046609 Vd NA 0.4661 L/kg 1compartment NA NA Rat Human DTXSID9046609 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046609 TK.Half.Life NA 7.983 hours 1compartment NA NA Rat Human -DTXSID9046609 Css NA 0.1754 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046609 Css NA 1.477 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046609 Css NA 0.2103 mg/L PBTK NA 50% Rat Human -DTXSID9046609 Css NA 1.002 mg/L PBTK NA 95% Rat Human -DTXSID9046651 Clint NA 25.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046651 Fup NA 0.0712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046651 Vd NA 2.692 L/kg 1compartment NA NA Human Human +DTXSID9046609 TK.Half.Life NA 1.992 hours 1compartment NA NA Rat Human +DTXSID9046609 Css NA 0.02366 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046609 Css NA 0.1719 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046609 Css NA 0.0167 mg/L PBTK NA 50% Rat Human +DTXSID9046609 Css NA 0.1066 mg/L PBTK NA 95% Rat Human +DTXSID9046651 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046651 Fup 0.0355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046651 Vd NA 2.355 L/kg 1compartment NA NA Human Human DTXSID9046651 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9046651 TK.Half.Life NA 15.59 hours 1compartment NA NA Human Human -DTXSID9046651 Css NA 0.6762 mg/L 3compartmentss NA 50% Human Human -DTXSID9046651 Css NA 4.403 mg/L 3compartmentss NA 95% Human Human -DTXSID9046651 Css NA 0.4634 mg/L PBTK NA 50% Human Human -DTXSID9046651 Css NA 2.939 mg/L PBTK NA 95% Human Human -DTXSID9046651 Clint NA 25.85 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046651 Fup NA 0.0712 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046651 Vd NA 2.021 L/kg 1compartment NA NA Rat Human +DTXSID9046651 TK.Half.Life NA 19.07 hours 1compartment NA NA Human Human +DTXSID9046651 Css NA 1.062 mg/L 3compartmentss NA 50% Human Human +DTXSID9046651 Css NA 7.399 mg/L 3compartmentss NA 95% Human Human +DTXSID9046651 Css NA 0.7024 mg/L PBTK NA 50% Human Human +DTXSID9046651 Css NA 4.622 mg/L PBTK NA 95% Human Human +DTXSID9046651 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046651 Fup 0.0355 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046651 Vd NA 1.761 L/kg 1compartment NA NA Rat Human DTXSID9046651 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046651 TK.Half.Life NA 3.555 hours 1compartment NA NA Rat Human -DTXSID9046651 Css NA 0.3756 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046651 Css NA 1.886 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046651 Css NA 0.245 mg/L PBTK NA 50% Rat Human -DTXSID9046651 Css NA 1.194 mg/L PBTK NA 95% Rat Human -DTXSID9046653 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046653 Fup NA 0.5699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046653 Vd NA 0.5442 L/kg 1compartment NA NA Human Human +DTXSID9046651 TK.Half.Life NA 5.216 hours 1compartment NA NA Rat Human +DTXSID9046651 Css NA 0.1372 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046651 Css NA 0.7757 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046651 Css NA 0.08917 mg/L PBTK NA 50% Rat Human +DTXSID9046651 Css NA 0.4872 mg/L PBTK NA 95% Rat Human +DTXSID9046653 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046653 Fup 0.804 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046653 Vd NA 0.6515 L/kg 1compartment NA NA Human Human DTXSID9046653 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046653 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human -DTXSID9046653 Css NA 1.339 mg/L 3compartmentss NA 50% Human Human -DTXSID9046653 Css NA 9.2 mg/L 3compartmentss NA 95% Human Human -DTXSID9046653 Css NA 1.025 mg/L PBTK NA 50% Human Human -DTXSID9046653 Css NA 5.677 mg/L PBTK NA 95% Human Human -DTXSID9046653 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046653 Fup NA 0.5699 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046653 Vd NA 0.5718 L/kg 1compartment NA NA Rat Human +DTXSID9046653 TK.Half.Life NA 5.243 hours 1compartment NA NA Human Human +DTXSID9046653 Css NA 0.5552 mg/L 3compartmentss NA 50% Human Human +DTXSID9046653 Css NA 3.31 mg/L 3compartmentss NA 95% Human Human +DTXSID9046653 Css NA 0.4468 mg/L PBTK NA 50% Human Human +DTXSID9046653 Css NA 2.127 mg/L PBTK NA 95% Human Human +DTXSID9046653 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046653 Fup 0.804 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046653 Vd NA 0.6887 L/kg 1compartment NA NA Rat Human DTXSID9046653 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046653 TK.Half.Life NA 2.212 hours 1compartment NA NA Rat Human -DTXSID9046653 Css NA 0.3573 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046653 Css NA 2.218 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046653 Css NA 0.2596 mg/L PBTK NA 50% Rat Human -DTXSID9046653 Css NA 1.282 mg/L PBTK NA 95% Rat Human -DTXSID9046657 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046657 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046657 Vd NA 1.798 L/kg 1compartment NA NA Human Human +DTXSID9046653 TK.Half.Life NA 1.888 hours 1compartment NA NA Rat Human +DTXSID9046653 Css NA 0.002794 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046653 Css NA 0.01846 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046653 Css NA 0.002186 mg/L PBTK NA 50% Rat Human +DTXSID9046653 Css NA 0.01136 mg/L PBTK NA 95% Rat Human +DTXSID9046657 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046657 Fup 0.848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046657 Vd NA 1.575 L/kg 1compartment NA NA Human Human DTXSID9046657 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9046657 TK.Half.Life NA 11.64 hours 1compartment NA NA Human Human -DTXSID9046657 Css NA 0.7038 mg/L 3compartmentss NA 50% Human Human -DTXSID9046657 Css NA 5.282 mg/L 3compartmentss NA 95% Human Human -DTXSID9046657 Css NA 0.6992 mg/L PBTK NA 50% Human Human -DTXSID9046657 Css NA 3.599 mg/L PBTK NA 95% Human Human -DTXSID9046657 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046657 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046657 Vd NA 1.833 L/kg 1compartment NA NA Rat Human +DTXSID9046657 TK.Half.Life NA 12.02 hours 1compartment NA NA Human Human +DTXSID9046657 Css NA 0.8152 mg/L 3compartmentss NA 50% Human Human +DTXSID9046657 Css NA 5.485 mg/L 3compartmentss NA 95% Human Human +DTXSID9046657 Css NA 0.7702 mg/L PBTK NA 50% Human Human +DTXSID9046657 Css NA 3.645 mg/L PBTK NA 95% Human Human +DTXSID9046657 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046657 Fup 0.848 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046657 Vd NA 1.604 L/kg 1compartment NA NA Rat Human DTXSID9046657 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046657 TK.Half.Life NA 4.042 hours 1compartment NA NA Rat Human -DTXSID9046657 Css NA 0.174 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046657 Css NA 1.256 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046657 Css NA 0.1722 mg/L PBTK NA 50% Rat Human -DTXSID9046657 Css NA 0.8001 mg/L PBTK NA 95% Rat Human -DTXSID9046659 Clint NA 83.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9046657 TK.Half.Life NA 4.171 hours 1compartment NA NA Rat Human +DTXSID9046657 Css NA 0.04737 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046657 Css NA 0.2979 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046657 Css NA 0.04561 mg/L PBTK NA 50% Rat Human +DTXSID9046657 Css NA 0.195 mg/L PBTK NA 95% Rat Human +DTXSID9046659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9046659 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9046659 Vd NA 2.288 L/kg 1compartment NA NA Human Human -DTXSID9046659 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046659 TK.Half.Life NA 11.45 hours 1compartment NA NA Human Human -DTXSID9046659 Css NA 0.6627 mg/L 3compartmentss NA 50% Human Human -DTXSID9046659 Css NA 5.299 mg/L 3compartmentss NA 95% Human Human -DTXSID9046659 Css NA 0.4304 mg/L PBTK NA 50% Human Human -DTXSID9046659 Css NA 3.281 mg/L PBTK NA 95% Human Human -DTXSID9046659 Clint NA 83.07 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9046659 Vd NA 1.638 L/kg 1compartment NA NA Human Human +DTXSID9046659 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9046659 TK.Half.Life NA 24.71 hours 1compartment NA NA Human Human +DTXSID9046659 Css NA 2.397 mg/L 3compartmentss NA 50% Human Human +DTXSID9046659 Css NA 21.47 mg/L 3compartmentss NA 95% Human Human +DTXSID9046659 Css NA 1.509 mg/L PBTK NA 50% Human Human +DTXSID9046659 Css NA 12.94 mg/L PBTK NA 95% Human Human +DTXSID9046659 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9046659 Fup 0.01 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9046659 Vd NA 1.699 L/kg 1compartment NA NA Rat Human -DTXSID9046659 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046659 TK.Half.Life NA 3.266 hours 1compartment NA NA Rat Human -DTXSID9046659 Css NA 0.3743 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046659 Css NA 2.504 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046659 Css NA 0.2308 mg/L PBTK NA 50% Rat Human -DTXSID9046659 Css NA 1.492 mg/L PBTK NA 95% Rat Human -DTXSID9046730 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046730 Fup NA 0.3066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046730 Vd NA 0.4176 L/kg 1compartment NA NA Human Human +DTXSID9046659 Vd NA 1.208 L/kg 1compartment NA NA Rat Human +DTXSID9046659 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9046659 TK.Half.Life NA 9.071 hours 1compartment NA NA Rat Human +DTXSID9046659 Css NA 0.3134 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046659 Css NA 2.364 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046659 Css NA 0.1906 mg/L PBTK NA 50% Rat Human +DTXSID9046659 Css NA 1.38 mg/L PBTK NA 95% Rat Human +DTXSID9046730 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046730 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046730 Vd NA 0.3399 L/kg 1compartment NA NA Human Human DTXSID9046730 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046730 TK.Half.Life NA 8.812 hours 1compartment NA NA Human Human -DTXSID9046730 Css NA 2.496 mg/L 3compartmentss NA 50% Human Human -DTXSID9046730 Css NA 9.922 mg/L 3compartmentss NA 95% Human Human -DTXSID9046730 Css NA 1.738 mg/L PBTK NA 50% Human Human -DTXSID9046730 Css NA 6.193 mg/L PBTK NA 95% Human Human -DTXSID9046730 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046730 Fup NA 0.3066 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046730 Vd NA 0.4239 L/kg 1compartment NA NA Rat Human +DTXSID9046730 TK.Half.Life NA 1.184 hours 1compartment NA NA Human Human +DTXSID9046730 Css NA 0.1844 mg/L 3compartmentss NA 50% Human Human +DTXSID9046730 Css NA 1.226 mg/L 3compartmentss NA 95% Human Human +DTXSID9046730 Css NA 0.1205 mg/L PBTK NA 50% Human Human +DTXSID9046730 Css NA 0.7643 mg/L PBTK NA 95% Human Human +DTXSID9046730 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046730 Fup 0.2 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046730 Vd NA 0.3439 L/kg 1compartment NA NA Rat Human DTXSID9046730 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046730 TK.Half.Life NA 3.048 hours 1compartment NA NA Rat Human -DTXSID9046730 Css NA 0.6855 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046730 Css NA 2.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046730 Css NA 0.4533 mg/L PBTK NA 50% Rat Human -DTXSID9046730 Css NA 1.342 mg/L PBTK NA 95% Rat Human +DTXSID9046730 TK.Half.Life NA 0.7033 hours 1compartment NA NA Rat Human +DTXSID9046730 Css NA 0.001815 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046730 Css NA 0.01002 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046730 Css NA 0.001127 mg/L PBTK NA 50% Rat Human +DTXSID9046730 Css NA 0.005946 mg/L PBTK NA 95% Rat Human DTXSID9046732 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9046732 Fup NA 0.7421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046732 Vd NA 0.6808 L/kg 1compartment NA NA Human Human +DTXSID9046732 Vd NA 0.5944 L/kg 1compartment NA NA Human Human DTXSID9046732 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046732 TK.Half.Life NA 5.934 hours 1compartment NA NA Human Human -DTXSID9046732 Css NA 1.049 mg/L 3compartmentss NA 50% Human Human -DTXSID9046732 Css NA 6.515 mg/L 3compartmentss NA 95% Human Human -DTXSID9046732 Css NA 0.8542 mg/L PBTK NA 50% Human Human -DTXSID9046732 Css NA 4.103 mg/L PBTK NA 95% Human Human +DTXSID9046732 TK.Half.Life NA 5.18 hours 1compartment NA NA Human Human +DTXSID9046732 Css NA 0.9168 mg/L 3compartmentss NA 50% Human Human +DTXSID9046732 Css NA 5.682 mg/L 3compartmentss NA 95% Human Human +DTXSID9046732 Css NA 0.728 mg/L PBTK NA 50% Human Human +DTXSID9046732 Css NA 3.592 mg/L PBTK NA 95% Human Human DTXSID9046732 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9046732 Fup NA 0.7421 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046732 Vd NA 0.7098 L/kg 1compartment NA NA Rat Human +DTXSID9046732 Vd NA 0.6345 L/kg 1compartment NA NA Rat Human DTXSID9046732 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046732 TK.Half.Life NA 2.109 hours 1compartment NA NA Rat Human -DTXSID9046732 Css NA 0.2684 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046732 Css NA 1.741 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046732 Css NA 0.2115 mg/L PBTK NA 50% Rat Human -DTXSID9046732 Css NA 1.029 mg/L PBTK NA 95% Rat Human -DTXSID9046734 Clint NA 14.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046734 Fup NA 0.5271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046734 Vd NA 2.544 L/kg 1compartment NA NA Human Human +DTXSID9046732 TK.Half.Life NA 1.885 hours 1compartment NA NA Rat Human +DTXSID9046732 Css NA 0.01772 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046732 Css NA 0.1397 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046732 Css NA 0.01341 mg/L PBTK NA 50% Rat Human +DTXSID9046732 Css NA 0.08837 mg/L PBTK NA 95% Rat Human +DTXSID9046734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046734 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046734 Vd NA 1.66 L/kg 1compartment NA NA Human Human DTXSID9046734 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046734 TK.Half.Life NA 2.672 hours 1compartment NA NA Human Human -DTXSID9046734 Css NA 0.05285 mg/L 3compartmentss NA 50% Human Human -DTXSID9046734 Css NA 0.4415 mg/L 3compartmentss NA 95% Human Human -DTXSID9046734 Css NA 0.05244 mg/L PBTK NA 50% Human Human -DTXSID9046734 Css NA 0.3578 mg/L PBTK NA 95% Human Human -DTXSID9046734 Clint NA 14.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046734 Fup NA 0.5271 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046734 Vd NA 2.413 L/kg 1compartment NA NA Rat Human +DTXSID9046734 TK.Half.Life NA 2.222 hours 1compartment NA NA Human Human +DTXSID9046734 Css NA 0.07262 mg/L 3compartmentss NA 50% Human Human +DTXSID9046734 Css NA 0.5423 mg/L 3compartmentss NA 95% Human Human +DTXSID9046734 Css NA 0.0589 mg/L PBTK NA 50% Human Human +DTXSID9046734 Css NA 0.3892 mg/L PBTK NA 95% Human Human +DTXSID9046734 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046734 Fup 0.26 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046734 Vd NA 1.557 L/kg 1compartment NA NA Rat Human DTXSID9046734 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046734 TK.Half.Life NA 1.28 hours 1compartment NA NA Rat Human -DTXSID9046734 Css NA 0.02706 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046734 Css NA 0.2037 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046734 Css NA 0.02672 mg/L PBTK NA 50% Rat Human -DTXSID9046734 Css NA 0.1467 mg/L PBTK NA 95% Rat Human +DTXSID9046734 TK.Half.Life NA 1.109 hours 1compartment NA NA Rat Human +DTXSID9046734 Css NA 0.009064 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046734 Css NA 0.05134 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046734 Css NA 0.007351 mg/L PBTK NA 50% Rat Human +DTXSID9046734 Css NA 0.03731 mg/L PBTK NA 95% Rat Human DTXSID9046736 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9046736 Fup NA 0.4431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046736 Vd NA 1.479 L/kg 1compartment NA NA Human Human -DTXSID9046736 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9046736 TK.Half.Life NA 23.71 hours 1compartment NA NA Human Human -DTXSID9046736 Css NA 1.573 mg/L 3compartmentss NA 50% Human Human -DTXSID9046736 Css NA 7.24 mg/L 3compartmentss NA 95% Human Human -DTXSID9046736 Css NA 1.338 mg/L PBTK NA 50% Human Human -DTXSID9046736 Css NA 4.941 mg/L PBTK NA 95% Human Human +DTXSID9046736 Vd NA 0.4659 L/kg 1compartment NA NA Human Human +DTXSID9046736 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046736 TK.Half.Life NA 6.802 hours 1compartment NA NA Human Human +DTXSID9046736 Css NA 1.42 mg/L 3compartmentss NA 50% Human Human +DTXSID9046736 Css NA 6.491 mg/L 3compartmentss NA 95% Human Human +DTXSID9046736 Css NA 1.029 mg/L PBTK NA 50% Human Human +DTXSID9046736 Css NA 4.072 mg/L PBTK NA 95% Human Human DTXSID9046736 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9046736 Fup NA 0.4431 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046736 Vd NA 1.357 L/kg 1compartment NA NA Rat Human +DTXSID9046736 Vd NA 0.4899 L/kg 1compartment NA NA Rat Human DTXSID9046736 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046736 TK.Half.Life NA 6.911 hours 1compartment NA NA Rat Human -DTXSID9046736 Css NA 0.4286 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046736 Css NA 1.7 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046736 Css NA 0.3516 mg/L PBTK NA 50% Rat Human -DTXSID9046736 Css NA 1.074 mg/L PBTK NA 95% Rat Human -DTXSID9046738 Clint NA 5.818 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046738 Fup NA 0.005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046738 Vd NA 0.5906 L/kg 1compartment NA NA Human Human -DTXSID9046738 Days.Css NA 10 Days PBTK NA NA Human Human -DTXSID9046738 TK.Half.Life NA 57.57 hours 1compartment NA NA Human Human -DTXSID9046738 Css NA 18.46 mg/L 3compartmentss NA 50% Human Human -DTXSID9046738 Css NA 155.9 mg/L 3compartmentss NA 95% Human Human -DTXSID9046738 Css NA 10.88 mg/L PBTK NA 50% Human Human -DTXSID9046738 Css NA 90.04 mg/L PBTK NA 95% Human Human -DTXSID9046738 Clint NA 5.818 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046738 Fup NA 0.005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046738 Vd NA 0.4407 L/kg 1compartment NA NA Rat Human -DTXSID9046738 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9046738 TK.Half.Life NA 26.72 hours 1compartment NA NA Rat Human -DTXSID9046738 Css NA 9.928 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046738 Css NA 65.31 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046738 Css NA 5.46 mg/L PBTK NA 50% Rat Human -DTXSID9046738 Css NA 35.44 mg/L PBTK NA 95% Rat Human -DTXSID9046780 Clint NA 31.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046780 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046780 Vd NA 2.173 L/kg 1compartment NA NA Human Human -DTXSID9046780 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046780 TK.Half.Life NA 5.394 hours 1compartment NA NA Human Human -DTXSID9046780 Css NA 0.272 mg/L 3compartmentss NA 50% Human Human -DTXSID9046780 Css NA 2.481 mg/L 3compartmentss NA 95% Human Human -DTXSID9046780 Css NA 0.1952 mg/L PBTK NA 50% Human Human -DTXSID9046780 Css NA 1.594 mg/L PBTK NA 95% Human Human -DTXSID9046780 Clint NA 31.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046780 Fup NA 0.0381 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046780 Vd NA 1.91 L/kg 1compartment NA NA Rat Human -DTXSID9046780 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046780 TK.Half.Life NA 2.493 hours 1compartment NA NA Rat Human -DTXSID9046780 Css NA 0.1528 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046780 Css NA 1.205 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046780 Css NA 0.1052 mg/L PBTK NA 50% Rat Human -DTXSID9046780 Css NA 0.7515 mg/L PBTK NA 95% Rat Human -DTXSID9046782 Clint NA 17.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9046736 TK.Half.Life NA 2.438 hours 1compartment NA NA Rat Human +DTXSID9046736 Css NA 0.02666 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046736 Css NA 0.1715 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046736 Css NA 0.01858 mg/L PBTK NA 50% Rat Human +DTXSID9046736 Css NA 0.1068 mg/L PBTK NA 95% Rat Human +DTXSID9046738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046738 Fup 0.0297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046738 Vd NA 0.8751 L/kg 1compartment NA NA Human Human +DTXSID9046738 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046738 TK.Half.Life NA 5.649 hours 1compartment NA NA Human Human +DTXSID9046738 Css NA 0.9928 mg/L 3compartmentss NA 50% Human Human +DTXSID9046738 Css NA 9.538 mg/L 3compartmentss NA 95% Human Human +DTXSID9046738 Css NA 0.6074 mg/L PBTK NA 50% Human Human +DTXSID9046738 Css NA 5.625 mg/L PBTK NA 95% Human Human +DTXSID9046738 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046738 Fup 0.0297 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046738 Vd NA 0.6614 L/kg 1compartment NA NA Rat Human +DTXSID9046738 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046738 TK.Half.Life NA 2.55 hours 1compartment NA NA Rat Human +DTXSID9046738 Css NA 0.1306 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046738 Css NA 0.969 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046738 Css NA 0.0771 mg/L PBTK NA 50% Rat Human +DTXSID9046738 Css NA 0.5552 mg/L PBTK NA 95% Rat Human +DTXSID9046780 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046780 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046780 Vd NA 2.782 L/kg 1compartment NA NA Human Human +DTXSID9046780 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9046780 TK.Half.Life NA 36.06 hours 1compartment NA NA Human Human +DTXSID9046780 Css NA 1.69 mg/L 3compartmentss NA 50% Human Human +DTXSID9046780 Css NA 11.91 mg/L 3compartmentss NA 95% Human Human +DTXSID9046780 Css NA 1.14 mg/L PBTK NA 50% Human Human +DTXSID9046780 Css NA 7.769 mg/L PBTK NA 95% Human Human +DTXSID9046780 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046780 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046780 Vd NA 2.081 L/kg 1compartment NA NA Rat Human +DTXSID9046780 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9046780 TK.Half.Life NA 7.256 hours 1compartment NA NA Rat Human +DTXSID9046780 Css NA 0.2175 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046780 Css NA 1.274 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046780 Css NA 0.1449 mg/L PBTK NA 50% Rat Human +DTXSID9046780 Css NA 0.8323 mg/L PBTK NA 95% Rat Human +DTXSID9046782 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human DTXSID9046782 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID9046782 Vd NA 1.086 L/kg 1compartment NA NA Human Human -DTXSID9046782 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9046782 TK.Half.Life NA 11.56 hours 1compartment NA NA Human Human -DTXSID9046782 Css NA 1.765 mg/L 3compartmentss NA 50% Human Human -DTXSID9046782 Css NA 16.09 mg/L 3compartmentss NA 95% Human Human -DTXSID9046782 Css NA 1.09 mg/L PBTK NA 50% Human Human -DTXSID9046782 Css NA 9.547 mg/L PBTK NA 95% Human Human -DTXSID9046782 Clint NA 17.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9046782 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9046782 TK.Half.Life NA 21.23 hours 1compartment NA NA Human Human +DTXSID9046782 Css NA 3.302 mg/L 3compartmentss NA 50% Human Human +DTXSID9046782 Css NA 28.58 mg/L 3compartmentss NA 95% Human Human +DTXSID9046782 Css NA 2.021 mg/L PBTK NA 50% Human Human +DTXSID9046782 Css NA 16.89 mg/L PBTK NA 95% Human Human +DTXSID9046782 Clint 9 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human DTXSID9046782 Fup 0.02 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID9046782 Vd NA 0.8082 L/kg 1compartment NA NA Rat Human -DTXSID9046782 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046782 TK.Half.Life NA 4.983 hours 1compartment NA NA Rat Human -DTXSID9046782 Css NA 1.002 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046782 Css NA 7.191 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046782 Css NA 0.5727 mg/L PBTK NA 50% Rat Human -DTXSID9046782 Css NA 3.983 mg/L PBTK NA 95% Rat Human -DTXSID9046784 Clint NA 26.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046784 Fup NA 0.8363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046784 Vd NA 0.538 L/kg 1compartment NA NA Human Human +DTXSID9046782 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9046782 TK.Half.Life NA 9.037 hours 1compartment NA NA Rat Human +DTXSID9046782 Css NA 0.411 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046782 Css NA 2.861 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046782 Css NA 0.2446 mg/L PBTK NA 50% Rat Human +DTXSID9046782 Css NA 1.633 mg/L PBTK NA 95% Rat Human +DTXSID9046784 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046784 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046784 Vd NA 0.4781 L/kg 1compartment NA NA Human Human DTXSID9046784 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046784 TK.Half.Life NA 0.4295 hours 1compartment NA NA Human Human -DTXSID9046784 Css NA 0.025 mg/L 3compartmentss NA 50% Human Human -DTXSID9046784 Css NA 0.2375 mg/L 3compartmentss NA 95% Human Human -DTXSID9046784 Css NA 0.01837 mg/L PBTK NA 50% Human Human -DTXSID9046784 Css NA 0.1554 mg/L PBTK NA 95% Human Human -DTXSID9046784 Clint NA 26.83 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046784 Fup NA 0.8363 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046784 Vd NA 0.5601 L/kg 1compartment NA NA Rat Human +DTXSID9046784 TK.Half.Life NA 4.661 hours 1compartment NA NA Human Human +DTXSID9046784 Css NA 0.6731 mg/L 3compartmentss NA 50% Human Human +DTXSID9046784 Css NA 4.371 mg/L 3compartmentss NA 95% Human Human +DTXSID9046784 Css NA 0.4998 mg/L PBTK NA 50% Human Human +DTXSID9046784 Css NA 2.691 mg/L PBTK NA 95% Human Human +DTXSID9046784 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046784 Fup 0.664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046784 Vd NA 0.4922 L/kg 1compartment NA NA Rat Human DTXSID9046784 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046784 TK.Half.Life NA 0.2095 hours 1compartment NA NA Rat Human -DTXSID9046784 Css NA 0.0128 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046784 Css NA 0.107 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046784 Css NA 0.009209 mg/L PBTK NA 50% Rat Human -DTXSID9046784 Css NA 0.06694 mg/L PBTK NA 95% Rat Human -DTXSID9046786 Clint NA 5.744 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046786 Fup NA 0.1349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046786 Vd NA 1.572 L/kg 1compartment NA NA Human Human +DTXSID9046784 TK.Half.Life NA 1.635 hours 1compartment NA NA Rat Human +DTXSID9046784 Css NA 0.003586 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046784 Css NA 0.02439 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046784 Css NA 0.002543 mg/L PBTK NA 50% Rat Human +DTXSID9046784 Css NA 0.01443 mg/L PBTK NA 95% Rat Human +DTXSID9046786 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046786 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046786 Vd NA 3.224 L/kg 1compartment NA NA Human Human DTXSID9046786 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046786 TK.Half.Life NA 7.614 hours 1compartment NA NA Human Human -DTXSID9046786 Css NA 0.5545 mg/L 3compartmentss NA 50% Human Human -DTXSID9046786 Css NA 4.456 mg/L 3compartmentss NA 95% Human Human -DTXSID9046786 Css NA 0.4266 mg/L PBTK NA 50% Human Human -DTXSID9046786 Css NA 2.886 mg/L PBTK NA 95% Human Human -DTXSID9046786 Clint NA 5.744 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046786 Fup NA 0.1349 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046786 Vd NA 1.568 L/kg 1compartment NA NA Rat Human +DTXSID9046786 TK.Half.Life NA 6.863 hours 1compartment NA NA Human Human +DTXSID9046786 Css NA 0.1303 mg/L 3compartmentss NA 50% Human Human +DTXSID9046786 Css NA 0.9775 mg/L 3compartmentss NA 95% Human Human +DTXSID9046786 Css NA 0.1446 mg/L PBTK NA 50% Human Human +DTXSID9046786 Css NA 0.8614 mg/L PBTK NA 95% Human Human +DTXSID9046786 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046786 Fup 0.305 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046786 Vd NA 3.259 L/kg 1compartment NA NA Rat Human DTXSID9046786 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046786 TK.Half.Life NA 4.603 hours 1compartment NA NA Rat Human -DTXSID9046786 Css NA 0.2924 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046786 Css NA 1.677 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046786 Css NA 0.2144 mg/L PBTK NA 50% Rat Human -DTXSID9046786 Css NA 1.009 mg/L PBTK NA 95% Rat Human -DTXSID9046788 Clint NA 33.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046788 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046788 Vd NA 2.168 L/kg 1compartment NA NA Human Human +DTXSID9046786 TK.Half.Life NA 4.037 hours 1compartment NA NA Rat Human +DTXSID9046786 Css NA 0.01503 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046786 Css NA 0.08562 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046786 Css NA 0.01734 mg/L PBTK NA 50% Rat Human +DTXSID9046786 Css NA 0.07224 mg/L PBTK NA 95% Rat Human +DTXSID9046788 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046788 Fup 0.0422 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046788 Vd NA 1.405 L/kg 1compartment NA NA Human Human DTXSID9046788 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046788 TK.Half.Life NA 4.933 hours 1compartment NA NA Human Human -DTXSID9046788 Css NA 0.2229 mg/L 3compartmentss NA 50% Human Human -DTXSID9046788 Css NA 1.713 mg/L 3compartmentss NA 95% Human Human -DTXSID9046788 Css NA 0.16 mg/L PBTK NA 50% Human Human -DTXSID9046788 Css NA 1.145 mg/L PBTK NA 95% Human Human -DTXSID9046788 Clint NA 33.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046788 Fup NA 0.0787 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046788 Vd NA 1.816 L/kg 1compartment NA NA Rat Human +DTXSID9046788 TK.Half.Life NA 6.359 hours 1compartment NA NA Human Human +DTXSID9046788 Css NA 0.6274 mg/L 3compartmentss NA 50% Human Human +DTXSID9046788 Css NA 5.626 mg/L 3compartmentss NA 95% Human Human +DTXSID9046788 Css NA 0.411 mg/L PBTK NA 50% Human Human +DTXSID9046788 Css NA 3.49 mg/L PBTK NA 95% Human Human +DTXSID9046788 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046788 Fup 0.0422 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046788 Vd NA 1.185 L/kg 1compartment NA NA Rat Human DTXSID9046788 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046788 TK.Half.Life NA 2.014 hours 1compartment NA NA Rat Human -DTXSID9046788 Css NA 0.1242 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046788 Css NA 0.7683 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046788 Css NA 0.08486 mg/L PBTK NA 50% Rat Human -DTXSID9046788 Css NA 0.4835 mg/L PBTK NA 95% Rat Human -DTXSID9046813 Clint NA 31.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046813 Fup NA 0.0645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046813 Vd NA 1.347 L/kg 1compartment NA NA Human Human +DTXSID9046788 TK.Half.Life NA 3.082 hours 1compartment NA NA Rat Human +DTXSID9046788 Css NA 0.08193 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046788 Css NA 0.6017 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046788 Css NA 0.05221 mg/L PBTK NA 50% Rat Human +DTXSID9046788 Css NA 0.352 mg/L PBTK NA 95% Rat Human +DTXSID9046813 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046813 Fup 0.0688 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046813 Vd NA 1.342 L/kg 1compartment NA NA Human Human DTXSID9046813 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046813 TK.Half.Life NA 3.809 hours 1compartment NA NA Human Human -DTXSID9046813 Css NA 0.3282 mg/L 3compartmentss NA 50% Human Human -DTXSID9046813 Css NA 2.498 mg/L 3compartmentss NA 95% Human Human -DTXSID9046813 Css NA 0.2115 mg/L PBTK NA 50% Human Human -DTXSID9046813 Css NA 1.548 mg/L PBTK NA 95% Human Human -DTXSID9046813 Clint NA 31.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046813 Fup NA 0.0645 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9046813 TK.Half.Life NA 4.722 hours 1compartment NA NA Human Human +DTXSID9046813 Css NA 0.4391 mg/L 3compartmentss NA 50% Human Human +DTXSID9046813 Css NA 3.189 mg/L 3compartmentss NA 95% Human Human +DTXSID9046813 Css NA 0.2867 mg/L PBTK NA 50% Human Human +DTXSID9046813 Css NA 2.005 mg/L PBTK NA 95% Human Human +DTXSID9046813 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046813 Fup 0.0688 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9046813 Vd NA 1.059 L/kg 1compartment NA NA Rat Human DTXSID9046813 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046813 TK.Half.Life NA 1.606 hours 1compartment NA NA Rat Human -DTXSID9046813 Css NA 0.1843 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046813 Css NA 1.08 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046813 Css NA 0.1128 mg/L PBTK NA 50% Rat Human -DTXSID9046813 Css NA 0.6311 mg/L PBTK NA 95% Rat Human -DTXSID9046815 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046815 Fup NA 0.4587 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046815 Vd NA 0.4867 L/kg 1compartment NA NA Human Human +DTXSID9046813 TK.Half.Life NA 2.024 hours 1compartment NA NA Rat Human +DTXSID9046813 Css NA 0.05664 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046813 Css NA 0.3314 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046813 Css NA 0.03597 mg/L PBTK NA 50% Rat Human +DTXSID9046813 Css NA 0.2035 mg/L PBTK NA 95% Rat Human +DTXSID9046815 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046815 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046815 Vd NA 0.5578 L/kg 1compartment NA NA Human Human DTXSID9046815 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046815 TK.Half.Life NA 6.87 hours 1compartment NA NA Human Human -DTXSID9046815 Css NA 1.622 mg/L 3compartmentss NA 50% Human Human -DTXSID9046815 Css NA 7.375 mg/L 3compartmentss NA 95% Human Human -DTXSID9046815 Css NA 1.186 mg/L PBTK NA 50% Human Human -DTXSID9046815 Css NA 4.656 mg/L PBTK NA 95% Human Human -DTXSID9046815 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046815 Fup NA 0.4587 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046815 Vd NA 0.5099 L/kg 1compartment NA NA Rat Human +DTXSID9046815 TK.Half.Life NA 6.139 hours 1compartment NA NA Human Human +DTXSID9046815 Css NA 0.7091 mg/L 3compartmentss NA 50% Human Human +DTXSID9046815 Css NA 4.982 mg/L 3compartmentss NA 95% Human Human +DTXSID9046815 Css NA 0.5458 mg/L PBTK NA 50% Human Human +DTXSID9046815 Css NA 3.084 mg/L PBTK NA 95% Human Human +DTXSID9046815 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046815 Fup 0.588 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046815 Vd NA 0.5853 L/kg 1compartment NA NA Rat Human DTXSID9046815 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046815 TK.Half.Life NA 2.451 hours 1compartment NA NA Rat Human -DTXSID9046815 Css NA 0.4442 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046815 Css NA 1.762 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046815 Css NA 0.3097 mg/L PBTK NA 50% Rat Human -DTXSID9046815 Css NA 1.035 mg/L PBTK NA 95% Rat Human -DTXSID9046817 Clint NA 10.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046817 Fup NA 0.0422 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046817 Vd NA 2.432 L/kg 1compartment NA NA Human Human -DTXSID9046817 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9046817 TK.Half.Life NA 36.06 hours 1compartment NA NA Human Human -DTXSID9046817 Css NA 2.145 mg/L 3compartmentss NA 50% Human Human -DTXSID9046817 Css NA 14.69 mg/L 3compartmentss NA 95% Human Human -DTXSID9046817 Css NA 1.425 mg/L PBTK NA 50% Human Human -DTXSID9046817 Css NA 9.352 mg/L PBTK NA 95% Human Human -DTXSID9046817 Clint NA 10.18 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046817 Fup NA 0.0422 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046817 Vd NA 1.824 L/kg 1compartment NA NA Rat Human -DTXSID9046817 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9046817 TK.Half.Life NA 9.283 hours 1compartment NA NA Rat Human -DTXSID9046817 Css NA 1.176 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046817 Css NA 5.893 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046817 Css NA 0.7454 mg/L PBTK NA 50% Rat Human -DTXSID9046817 Css NA 3.586 mg/L PBTK NA 95% Rat Human -DTXSID9046819 Clint NA 26.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046819 Fup NA 0.6192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046819 Vd NA 1.445 L/kg 1compartment NA NA Human Human -DTXSID9046819 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046819 TK.Half.Life NA 1.092 hours 1compartment NA NA Human Human -DTXSID9046819 Css NA 0.02481 mg/L 3compartmentss NA 50% Human Human -DTXSID9046819 Css NA 0.2781 mg/L 3compartmentss NA 95% Human Human -DTXSID9046819 Css NA 0.02277 mg/L PBTK NA 50% Human Human -DTXSID9046819 Css NA 0.2004 mg/L PBTK NA 95% Human Human -DTXSID9046819 Clint NA 26.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046819 Fup NA 0.6192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046819 Vd NA 1.426 L/kg 1compartment NA NA Rat Human -DTXSID9046819 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046819 TK.Half.Life NA 0.5344 hours 1compartment NA NA Rat Human -DTXSID9046819 Css NA 0.01274 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046819 Css NA 0.1277 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046819 Css NA 0.01154 mg/L PBTK NA 50% Rat Human -DTXSID9046819 Css NA 0.08671 mg/L PBTK NA 95% Rat Human -DTXSID9046861 Clint NA 6.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9046815 TK.Half.Life NA 2.196 hours 1compartment NA NA Rat Human +DTXSID9046815 Css NA 0.00374 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046815 Css NA 0.02636 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046815 Css NA 0.002758 mg/L PBTK NA 50% Rat Human +DTXSID9046815 Css NA 0.01582 mg/L PBTK NA 95% Rat Human +DTXSID9046817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046817 Fup 0.0334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046817 Vd NA 1.822 L/kg 1compartment NA NA Human Human +DTXSID9046817 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046817 TK.Half.Life NA 12.37 hours 1compartment NA NA Human Human +DTXSID9046817 Css NA 0.985 mg/L 3compartmentss NA 50% Human Human +DTXSID9046817 Css NA 7.272 mg/L 3compartmentss NA 95% Human Human +DTXSID9046817 Css NA 0.6332 mg/L PBTK NA 50% Human Human +DTXSID9046817 Css NA 4.469 mg/L PBTK NA 95% Human Human +DTXSID9046817 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046817 Fup 0.0334 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046817 Vd NA 1.364 L/kg 1compartment NA NA Rat Human +DTXSID9046817 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046817 TK.Half.Life NA 4.332 hours 1compartment NA NA Rat Human +DTXSID9046817 Css NA 0.1275 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046817 Css NA 0.7662 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046817 Css NA 0.07984 mg/L PBTK NA 50% Rat Human +DTXSID9046817 Css NA 0.4613 mg/L PBTK NA 95% Rat Human +DTXSID9046861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9046861 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9046861 Vd NA 3.246 L/kg 1compartment NA NA Human Human +DTXSID9046861 Vd NA 3.581 L/kg 1compartment NA NA Human Human DTXSID9046861 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046861 TK.Half.Life NA 12.85 hours 1compartment NA NA Human Human -DTXSID9046861 Css NA 0.3634 mg/L 3compartmentss NA 50% Human Human -DTXSID9046861 Css NA 2.726 mg/L 3compartmentss NA 95% Human Human -DTXSID9046861 Css NA 0.3376 mg/L PBTK NA 50% Human Human -DTXSID9046861 Css NA 2.092 mg/L PBTK NA 95% Human Human -DTXSID9046861 Clint NA 6.37 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9046861 TK.Half.Life NA 6.178 hours 1compartment NA NA Human Human +DTXSID9046861 Css NA 0.1167 mg/L 3compartmentss NA 50% Human Human +DTXSID9046861 Css NA 0.9174 mg/L 3compartmentss NA 95% Human Human +DTXSID9046861 Css NA 0.1067 mg/L PBTK NA 50% Human Human +DTXSID9046861 Css NA 0.7429 mg/L PBTK NA 95% Human Human +DTXSID9046861 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9046861 Fup 0.15 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9046861 Vd NA 3.033 L/kg 1compartment NA NA Rat Human +DTXSID9046861 Vd NA 3.229 L/kg 1compartment NA NA Rat Human DTXSID9046861 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046861 TK.Half.Life NA 6.001 hours 1compartment NA NA Rat Human -DTXSID9046861 Css NA 0.1879 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046861 Css NA 1.074 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046861 Css NA 0.1698 mg/L PBTK NA 50% Rat Human -DTXSID9046861 Css NA 0.7885 mg/L PBTK NA 95% Rat Human -DTXSID9046863 Clint NA 10.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046863 Fup NA 0.4006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046863 Vd NA 1.866 L/kg 1compartment NA NA Human Human +DTXSID9046861 TK.Half.Life NA 2.412 hours 1compartment NA NA Rat Human +DTXSID9046861 Css NA 0.0147 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046861 Css NA 0.09626 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046861 Css NA 0.01376 mg/L PBTK NA 50% Rat Human +DTXSID9046861 Css NA 0.07688 mg/L PBTK NA 95% Rat Human +DTXSID9046863 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046863 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046863 Vd NA 0.4256 L/kg 1compartment NA NA Human Human DTXSID9046863 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046863 TK.Half.Life NA 3.344 hours 1compartment NA NA Human Human -DTXSID9046863 Css NA 0.1316 mg/L 3compartmentss NA 50% Human Human -DTXSID9046863 Css NA 0.8488 mg/L 3compartmentss NA 95% Human Human -DTXSID9046863 Css NA 0.1052 mg/L PBTK NA 50% Human Human -DTXSID9046863 Css NA 0.6202 mg/L PBTK NA 95% Human Human -DTXSID9046863 Clint NA 10.55 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046863 Fup NA 0.4006 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046863 Vd NA 1.51 L/kg 1compartment NA NA Rat Human +DTXSID9046863 TK.Half.Life NA 1.766 hours 1compartment NA NA Human Human +DTXSID9046863 Css NA 0.4026 mg/L 3compartmentss NA 50% Human Human +DTXSID9046863 Css NA 2.554 mg/L 3compartmentss NA 95% Human Human +DTXSID9046863 Css NA 0.2634 mg/L PBTK NA 50% Human Human +DTXSID9046863 Css NA 1.579 mg/L PBTK NA 95% Human Human +DTXSID9046863 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046863 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046863 Vd NA 0.3961 L/kg 1compartment NA NA Rat Human DTXSID9046863 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046863 TK.Half.Life NA 1.259 hours 1compartment NA NA Rat Human -DTXSID9046863 Css NA 0.06866 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046863 Css NA 0.3413 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046863 Css NA 0.05304 mg/L PBTK NA 50% Rat Human -DTXSID9046863 Css NA 0.2324 mg/L PBTK NA 95% Rat Human -DTXSID9046867 Clint NA 2.263 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046867 Fup NA 0.0398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046867 Vd NA 1.512 L/kg 1compartment NA NA Human Human -DTXSID9046867 Days.Css NA 9 Days PBTK NA NA Human Human -DTXSID9046867 TK.Half.Life NA 59.19 hours 1compartment NA NA Human Human -DTXSID9046867 Css NA 6.43 mg/L 3compartmentss NA 50% Human Human -DTXSID9046867 Css NA 40.82 mg/L 3compartmentss NA 95% Human Human -DTXSID9046867 Css NA 4.092 mg/L PBTK NA 50% Human Human -DTXSID9046867 Css NA 24.71 mg/L PBTK NA 95% Human Human -DTXSID9046867 Clint NA 2.263 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046867 Fup NA 0.0398 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046867 Vd NA 1.132 L/kg 1compartment NA NA Rat Human -DTXSID9046867 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9046867 TK.Half.Life NA 20.31 hours 1compartment NA NA Rat Human -DTXSID9046867 Css NA 3.156 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046867 Css NA 15.51 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046867 Css NA 1.883 mg/L PBTK NA 50% Rat Human -DTXSID9046867 Css NA 8.631 mg/L PBTK NA 95% Rat Human -DTXSID9046869 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046869 Fup NA 0.4631 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046869 Vd NA 2.401 L/kg 1compartment NA NA Human Human +DTXSID9046863 TK.Half.Life NA 0.973 hours 1compartment NA NA Rat Human +DTXSID9046863 Css NA 0.01799 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046863 Css NA 0.1306 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046863 Css NA 0.0115 mg/L PBTK NA 50% Rat Human +DTXSID9046863 Css NA 0.07855 mg/L PBTK NA 95% Rat Human +DTXSID9046867 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046867 Fup 0.0443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046867 Vd NA 1.484 L/kg 1compartment NA NA Human Human +DTXSID9046867 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9046867 TK.Half.Life NA 22.07 hours 1compartment NA NA Human Human +DTXSID9046867 Css NA 2.322 mg/L 3compartmentss NA 50% Human Human +DTXSID9046867 Css NA 16.05 mg/L 3compartmentss NA 95% Human Human +DTXSID9046867 Css NA 1.478 mg/L PBTK NA 50% Human Human +DTXSID9046867 Css NA 9.865 mg/L PBTK NA 95% Human Human +DTXSID9046867 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046867 Fup 0.0443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046867 Vd NA 1.114 L/kg 1compartment NA NA Rat Human +DTXSID9046867 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9046867 TK.Half.Life NA 8.343 hours 1compartment NA NA Rat Human +DTXSID9046867 Css NA 0.2825 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046867 Css NA 1.533 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046867 Css NA 0.1754 mg/L PBTK NA 50% Rat Human +DTXSID9046867 Css NA 0.897 mg/L PBTK NA 95% Rat Human +DTXSID9046869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046869 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046869 Vd NA 2.348 L/kg 1compartment NA NA Human Human DTXSID9046869 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046869 TK.Half.Life NA 1.548 hours 1compartment NA NA Human Human -DTXSID9046869 Css NA 0.01586 mg/L 3compartmentss NA 50% Human Human -DTXSID9046869 Css NA 0.1616 mg/L 3compartmentss NA 95% Human Human -DTXSID9046869 Css NA 0.0179 mg/L PBTK NA 50% Human Human -DTXSID9046869 Css NA 0.1388 mg/L PBTK NA 95% Human Human -DTXSID9046869 Clint NA 38.14 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046869 Fup NA 0.4631 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046869 Vd NA 2.366 L/kg 1compartment NA NA Rat Human +DTXSID9046869 TK.Half.Life NA 1.836 hours 1compartment NA NA Human Human +DTXSID9046869 Css NA 0.02572 mg/L 3compartmentss NA 50% Human Human +DTXSID9046869 Css NA 0.2641 mg/L 3compartmentss NA 95% Human Human +DTXSID9046869 Css NA 0.02859 mg/L PBTK NA 50% Human Human +DTXSID9046869 Css NA 0.2228 mg/L PBTK NA 95% Human Human +DTXSID9046869 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046869 Fup 0.47 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046869 Vd NA 2.314 L/kg 1compartment NA NA Rat Human DTXSID9046869 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046869 TK.Half.Life NA 0.7678 hours 1compartment NA NA Rat Human -DTXSID9046869 Css NA 0.008252 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046869 Css NA 0.06998 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046869 Css NA 0.009222 mg/L PBTK NA 50% Rat Human -DTXSID9046869 Css NA 0.0588 mg/L PBTK NA 95% Rat Human -DTXSID9046942 Clint NA 31.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046942 Fup NA 0.0881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046942 Vd NA 3.125 L/kg 1compartment NA NA Human Human -DTXSID9046942 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9046942 TK.Half.Life NA 35.58 hours 1compartment NA NA Human Human -DTXSID9046942 Css NA 1.333 mg/L 3compartmentss NA 50% Human Human -DTXSID9046942 Css NA 8.492 mg/L 3compartmentss NA 95% Human Human -DTXSID9046942 Css NA 0.9324 mg/L PBTK NA 50% Human Human -DTXSID9046942 Css NA 5.737 mg/L PBTK NA 95% Human Human -DTXSID9046942 Clint NA 31.45 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046942 Fup NA 0.0881 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046942 Vd NA 2.356 L/kg 1compartment NA NA Rat Human -DTXSID9046942 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9046942 TK.Half.Life NA 5.348 hours 1compartment NA NA Rat Human -DTXSID9046942 Css NA 0.7381 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046942 Css NA 3.875 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046942 Css NA 0.4943 mg/L PBTK NA 50% Rat Human -DTXSID9046942 Css NA 2.538 mg/L PBTK NA 95% Rat Human -DTXSID9046946 Clint NA 59.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046946 Fup NA 0.2081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046946 Vd NA 2.908 L/kg 1compartment NA NA Human Human +DTXSID9046869 TK.Half.Life NA 0.9582 hours 1compartment NA NA Rat Human +DTXSID9046869 Css NA 0.003071 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046869 Css NA 0.02555 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046869 Css NA 0.003546 mg/L PBTK NA 50% Rat Human +DTXSID9046869 Css NA 0.02165 mg/L PBTK NA 95% Rat Human +DTXSID9046942 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046942 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046942 Vd NA 2.597 L/kg 1compartment NA NA Human Human +DTXSID9046942 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046942 TK.Half.Life NA 3.28 hours 1compartment NA NA Human Human +DTXSID9046942 Css NA 0.0632 mg/L 3compartmentss NA 50% Human Human +DTXSID9046942 Css NA 0.5063 mg/L 3compartmentss NA 95% Human Human +DTXSID9046942 Css NA 0.06148 mg/L PBTK NA 50% Human Human +DTXSID9046942 Css NA 0.4047 mg/L PBTK NA 95% Human Human +DTXSID9046942 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046942 Fup 0.208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046942 Vd NA 2.617 L/kg 1compartment NA NA Rat Human +DTXSID9046942 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046942 TK.Half.Life NA 1.88 hours 1compartment NA NA Rat Human +DTXSID9046942 Css NA 0.007685 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046942 Css NA 0.04709 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046942 Css NA 0.007782 mg/L PBTK NA 50% Rat Human +DTXSID9046942 Css NA 0.03937 mg/L PBTK NA 95% Rat Human +DTXSID9046944 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046944 Fup 0.28 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9046944 Vd NA 1.035 L/kg 1compartment NA NA Human Human +DTXSID9046944 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9046944 TK.Half.Life NA 2.87 hours 1compartment NA NA Human Human +DTXSID9046944 Css NA 0.242 mg/L 3compartmentss NA 50% Human Human +DTXSID9046944 Css NA 1.558 mg/L 3compartmentss NA 95% Human Human +DTXSID9046944 Css NA 0.1778 mg/L PBTK NA 50% Human Human +DTXSID9046944 Css NA 1.027 mg/L PBTK NA 95% Human Human +DTXSID9046944 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046944 Fup 0.28 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9046944 Vd NA 0.8777 L/kg 1compartment NA NA Rat Human +DTXSID9046944 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9046944 TK.Half.Life NA 1.33 hours 1compartment NA NA Rat Human +DTXSID9046944 Css NA 0.02882 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046944 Css NA 0.1325 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046944 Css NA 0.02113 mg/L PBTK NA 50% Rat Human +DTXSID9046944 Css NA 0.08514 mg/L PBTK NA 95% Rat Human +DTXSID9046946 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046946 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046946 Vd NA 3.315 L/kg 1compartment NA NA Human Human DTXSID9046946 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046946 TK.Half.Life NA 3.517 hours 1compartment NA NA Human Human -DTXSID9046946 Css NA 0.05936 mg/L 3compartmentss NA 50% Human Human -DTXSID9046946 Css NA 0.3926 mg/L 3compartmentss NA 95% Human Human -DTXSID9046946 Css NA 0.04868 mg/L PBTK NA 50% Human Human -DTXSID9046946 Css NA 0.299 mg/L PBTK NA 95% Human Human -DTXSID9046946 Clint NA 59.19 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046946 Fup NA 0.2081 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046946 Vd NA 2.448 L/kg 1compartment NA NA Rat Human +DTXSID9046946 TK.Half.Life NA 8.818 hours 1compartment NA NA Human Human +DTXSID9046946 Css NA 0.2061 mg/L 3compartmentss NA 50% Human Human +DTXSID9046946 Css NA 1.408 mg/L 3compartmentss NA 95% Human Human +DTXSID9046946 Css NA 0.1685 mg/L PBTK NA 50% Human Human +DTXSID9046946 Css NA 1.068 mg/L PBTK NA 95% Human Human +DTXSID9046946 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046946 Fup 0.291 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046946 Vd NA 2.705 L/kg 1compartment NA NA Rat Human DTXSID9046946 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046946 TK.Half.Life NA 1.244 hours 1compartment NA NA Rat Human -DTXSID9046946 Css NA 0.03231 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046946 Css NA 0.1813 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046946 Css NA 0.02585 mg/L PBTK NA 50% Rat Human -DTXSID9046946 Css NA 0.1369 mg/L PBTK NA 95% Rat Human -DTXSID9046992 Clint NA 121.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046992 Fup NA 0.0227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046992 Vd NA 2.048 L/kg 1compartment NA NA Human Human -DTXSID9046992 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046992 TK.Half.Life NA 4.868 hours 1compartment NA NA Human Human -DTXSID9046992 Css NA 0.2521 mg/L 3compartmentss NA 50% Human Human -DTXSID9046992 Css NA 2.19 mg/L 3compartmentss NA 95% Human Human -DTXSID9046992 Css NA 0.1637 mg/L PBTK NA 50% Human Human -DTXSID9046992 Css NA 1.332 mg/L PBTK NA 95% Human Human -DTXSID9046992 Clint NA 121.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046992 Fup NA 0.0227 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046992 Vd NA 1.556 L/kg 1compartment NA NA Rat Human -DTXSID9046992 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046992 TK.Half.Life NA 1.643 hours 1compartment NA NA Rat Human -DTXSID9046992 Css NA 0.1404 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046992 Css NA 1.037 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046992 Css NA 0.08647 mg/L PBTK NA 50% Rat Human -DTXSID9046992 Css NA 0.6023 mg/L PBTK NA 95% Rat Human -DTXSID9046994 Clint NA 24.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046994 Fup NA 0.7504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9046994 Vd NA 1.59 L/kg 1compartment NA NA Human Human +DTXSID9046946 TK.Half.Life NA 2.253 hours 1compartment NA NA Rat Human +DTXSID9046946 Css NA 0.02591 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046946 Css NA 0.1349 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046946 Css NA 0.02132 mg/L PBTK NA 50% Rat Human +DTXSID9046946 Css NA 0.1048 mg/L PBTK NA 95% Rat Human +DTXSID9046992 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046992 Fup 0.0647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046992 Vd NA 2.798 L/kg 1compartment NA NA Human Human +DTXSID9046992 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9046992 TK.Half.Life NA 19.88 hours 1compartment NA NA Human Human +DTXSID9046992 Css NA 0.8285 mg/L 3compartmentss NA 50% Human Human +DTXSID9046992 Css NA 5.592 mg/L 3compartmentss NA 95% Human Human +DTXSID9046992 Css NA 0.5786 mg/L PBTK NA 50% Human Human +DTXSID9046992 Css NA 3.688 mg/L PBTK NA 95% Human Human +DTXSID9046992 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046992 Fup 0.0647 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046992 Vd NA 2.139 L/kg 1compartment NA NA Rat Human +DTXSID9046992 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9046992 TK.Half.Life NA 4.554 hours 1compartment NA NA Rat Human +DTXSID9046992 Css NA 0.1058 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046992 Css NA 0.5757 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046992 Css NA 0.0735 mg/L PBTK NA 50% Rat Human +DTXSID9046992 Css NA 0.3848 mg/L PBTK NA 95% Rat Human +DTXSID9046994 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046994 Fup 0.678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9046994 Vd NA 0.5815 L/kg 1compartment NA NA Human Human DTXSID9046994 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9046994 TK.Half.Life NA 1.134 hours 1compartment NA NA Human Human -DTXSID9046994 Css NA 0.02438 mg/L 3compartmentss NA 50% Human Human -DTXSID9046994 Css NA 0.2481 mg/L 3compartmentss NA 95% Human Human -DTXSID9046994 Css NA 0.02217 mg/L PBTK NA 50% Human Human -DTXSID9046994 Css NA 0.1863 mg/L PBTK NA 95% Human Human -DTXSID9046994 Clint NA 24.57 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046994 Fup NA 0.7504 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9046994 Vd NA 1.603 L/kg 1compartment NA NA Rat Human +DTXSID9046994 TK.Half.Life NA 5.563 hours 1compartment NA NA Human Human +DTXSID9046994 Css NA 1.15 mg/L 3compartmentss NA 50% Human Human +DTXSID9046994 Css NA 7.204 mg/L 3compartmentss NA 95% Human Human +DTXSID9046994 Css NA 0.879 mg/L PBTK NA 50% Human Human +DTXSID9046994 Css NA 4.531 mg/L PBTK NA 95% Human Human +DTXSID9046994 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046994 Fup 0.678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9046994 Vd NA 0.5914 L/kg 1compartment NA NA Rat Human DTXSID9046994 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9046994 TK.Half.Life NA 0.5594 hours 1compartment NA NA Rat Human -DTXSID9046994 Css NA 0.01202 mg/L 3compartmentss NA 50% Rat Human -DTXSID9046994 Css NA 0.1163 mg/L 3compartmentss NA 95% Rat Human -DTXSID9046994 Css NA 0.01102 mg/L PBTK NA 50% Rat Human -DTXSID9046994 Css NA 0.07888 mg/L PBTK NA 95% Rat Human -DTXSID9047041 Clint NA 32.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047041 Fup NA 0.101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047041 Vd NA 1.452 L/kg 1compartment NA NA Human Human +DTXSID9046994 TK.Half.Life NA 1.924 hours 1compartment NA NA Rat Human +DTXSID9046994 Css NA 0.06876 mg/L 3compartmentss NA 50% Rat Human +DTXSID9046994 Css NA 0.4226 mg/L 3compartmentss NA 95% Rat Human +DTXSID9046994 Css NA 0.05246 mg/L PBTK NA 50% Rat Human +DTXSID9046994 Css NA 0.2533 mg/L PBTK NA 95% Rat Human +DTXSID9047041 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047041 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047041 Vd NA 2.576 L/kg 1compartment NA NA Human Human DTXSID9047041 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047041 TK.Half.Life NA 3.155 hours 1compartment NA NA Human Human -DTXSID9047041 Css NA 0.2133 mg/L 3compartmentss NA 50% Human Human -DTXSID9047041 Css NA 1.602 mg/L 3compartmentss NA 95% Human Human -DTXSID9047041 Css NA 0.1408 mg/L PBTK NA 50% Human Human -DTXSID9047041 Css NA 1.011 mg/L PBTK NA 95% Human Human -DTXSID9047041 Clint NA 32.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047041 Fup NA 0.101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047041 Vd NA 1.107 L/kg 1compartment NA NA Rat Human +DTXSID9047041 TK.Half.Life NA 10.46 hours 1compartment NA NA Human Human +DTXSID9047041 Css NA 0.4333 mg/L 3compartmentss NA 50% Human Human +DTXSID9047041 Css NA 2.844 mg/L 3compartmentss NA 95% Human Human +DTXSID9047041 Css NA 0.3018 mg/L PBTK NA 50% Human Human +DTXSID9047041 Css NA 1.885 mg/L PBTK NA 95% Human Human +DTXSID9047041 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047041 Fup 0.124 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047041 Vd NA 1.945 L/kg 1compartment NA NA Rat Human DTXSID9047041 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047041 TK.Half.Life NA 1.209 hours 1compartment NA NA Rat Human -DTXSID9047041 Css NA 0.1205 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047041 Css NA 0.7051 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047041 Css NA 0.07498 mg/L PBTK NA 50% Rat Human -DTXSID9047041 Css NA 0.4134 mg/L PBTK NA 95% Rat Human -DTXSID9047043 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047043 Fup NA 0.4541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047043 Vd NA 0.5118 L/kg 1compartment NA NA Human Human -DTXSID9047043 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047043 TK.Half.Life NA 7.292 hours 1compartment NA NA Human Human -DTXSID9047043 Css NA 1.586 mg/L 3compartmentss NA 50% Human Human -DTXSID9047043 Css NA 7.632 mg/L 3compartmentss NA 95% Human Human -DTXSID9047043 Css NA 1.176 mg/L PBTK NA 50% Human Human -DTXSID9047043 Css NA 4.818 mg/L PBTK NA 95% Human Human -DTXSID9047043 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047043 Fup NA 0.4541 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047043 Vd NA 0.5325 L/kg 1compartment NA NA Rat Human -DTXSID9047043 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047043 TK.Half.Life NA 2.584 hours 1compartment NA NA Rat Human -DTXSID9047043 Css NA 0.438 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047043 Css NA 1.766 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047043 Css NA 0.3102 mg/L PBTK NA 50% Rat Human -DTXSID9047043 Css NA 1.042 mg/L PBTK NA 95% Rat Human -DTXSID9047099 Clint NA 0.1461 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047099 Fup NA 0.1187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047099 Vd NA 2.565 L/kg 1compartment NA NA Human Human -DTXSID9047099 Days.Css NA 79 Days PBTK NA NA Human Human -DTXSID9047099 TK.Half.Life NA 347.8 hours 1compartment NA NA Human Human -DTXSID9047099 Css NA 16.64 mg/L 3compartmentss NA 50% Human Human -DTXSID9047099 Css NA 53.88 mg/L 3compartmentss NA 95% Human Human -DTXSID9047099 Css NA 11.62 mg/L PBTK NA 50% Human Human -DTXSID9047099 Css NA 34.49 mg/L PBTK NA 95% Human Human -DTXSID9047099 Clint NA 0.1461 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047099 Fup NA 0.1187 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047099 Vd NA 1.936 L/kg 1compartment NA NA Rat Human -DTXSID9047099 Days.Css NA 22 Days PBTK NA NA Rat Human -DTXSID9047099 TK.Half.Life NA 48 hours 1compartment NA NA Rat Human -DTXSID9047099 Css NA 5.387 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047099 Css NA 14.13 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047099 Css NA 3.572 mg/L PBTK NA 50% Rat Human -DTXSID9047099 Css NA 8.383 mg/L PBTK NA 95% Rat Human -DTXSID9047126 Clint NA 127.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047126 Fup NA 0.2458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047126 Vd NA 1.619 L/kg 1compartment NA NA Human Human +DTXSID9047041 TK.Half.Life NA 2.656 hours 1compartment NA NA Rat Human +DTXSID9047041 Css NA 0.05614 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047041 Css NA 0.2844 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047041 Css NA 0.03837 mg/L PBTK NA 50% Rat Human +DTXSID9047041 Css NA 0.1885 mg/L PBTK NA 95% Rat Human +DTXSID9047091 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047091 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047091 Vd NA 2.43 L/kg 1compartment NA NA Human Human +DTXSID9047091 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9047091 TK.Half.Life NA 8.173 hours 1compartment NA NA Human Human +DTXSID9047091 Css NA 0.3399 mg/L 3compartmentss NA 50% Human Human +DTXSID9047091 Css NA 2.418 mg/L 3compartmentss NA 95% Human Human +DTXSID9047091 Css NA 0.2366 mg/L PBTK NA 50% Human Human +DTXSID9047091 Css NA 1.602 mg/L PBTK NA 95% Human Human +DTXSID9047091 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047091 Fup 0.136 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047091 Vd NA 1.841 L/kg 1compartment NA NA Rat Human +DTXSID9047091 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9047091 TK.Half.Life NA 2.279 hours 1compartment NA NA Rat Human +DTXSID9047091 Css NA 0.0439 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047091 Css NA 0.2279 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047091 Css NA 0.03048 mg/L PBTK NA 50% Rat Human +DTXSID9047091 Css NA 0.152 mg/L PBTK NA 95% Rat Human +DTXSID9047095 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047095 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047095 Vd NA 1.753 L/kg 1compartment NA NA Human Human +DTXSID9047095 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9047095 TK.Half.Life NA 4.211 hours 1compartment NA NA Human Human +DTXSID9047095 Css NA 0.2263 mg/L 3compartmentss NA 50% Human Human +DTXSID9047095 Css NA 1.754 mg/L 3compartmentss NA 95% Human Human +DTXSID9047095 Css NA 0.1562 mg/L PBTK NA 50% Human Human +DTXSID9047095 Css NA 1.132 mg/L PBTK NA 95% Human Human +DTXSID9047095 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047095 Fup 0.14 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047095 Vd NA 1.346 L/kg 1compartment NA NA Rat Human +DTXSID9047095 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9047095 TK.Half.Life NA 1.53 hours 1compartment NA NA Rat Human +DTXSID9047095 Css NA 0.02892 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047095 Css NA 0.1641 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047095 Css NA 0.0196 mg/L PBTK NA 50% Rat Human +DTXSID9047095 Css NA 0.1034 mg/L PBTK NA 95% Rat Human +DTXSID9047099 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047099 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047099 Vd NA 2.263 L/kg 1compartment NA NA Human Human +DTXSID9047099 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9047099 TK.Half.Life NA 5.436 hours 1compartment NA NA Human Human +DTXSID9047099 Css NA 0.1939 mg/L 3compartmentss NA 50% Human Human +DTXSID9047099 Css NA 1.247 mg/L 3compartmentss NA 95% Human Human +DTXSID9047099 Css NA 0.1397 mg/L PBTK NA 50% Human Human +DTXSID9047099 Css NA 0.8636 mg/L PBTK NA 95% Human Human +DTXSID9047099 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047099 Fup 0.188 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047099 Vd NA 1.731 L/kg 1compartment NA NA Rat Human +DTXSID9047099 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9047099 TK.Half.Life NA 1.678 hours 1compartment NA NA Rat Human +DTXSID9047099 Css NA 0.02476 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047099 Css NA 0.1234 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047099 Css NA 0.01779 mg/L PBTK NA 50% Rat Human +DTXSID9047099 Css NA 0.08502 mg/L PBTK NA 95% Rat Human +DTXSID9047126 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047126 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047126 Vd NA 1.363 L/kg 1compartment NA NA Human Human DTXSID9047126 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047126 TK.Half.Life NA 1.45 hours 1compartment NA NA Human Human -DTXSID9047126 Css NA 0.01855 mg/L 3compartmentss NA 50% Human Human -DTXSID9047126 Css NA 0.1354 mg/L 3compartmentss NA 95% Human Human -DTXSID9047126 Css NA 0.01375 mg/L PBTK NA 50% Human Human -DTXSID9047126 Css NA 0.09242 mg/L PBTK NA 95% Human Human -DTXSID9047126 Clint NA 127.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047126 Fup NA 0.2458 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047126 Vd NA 1.283 L/kg 1compartment NA NA Rat Human +DTXSID9047126 TK.Half.Life NA 2.148 hours 1compartment NA NA Human Human +DTXSID9047126 Css NA 0.09846 mg/L 3compartmentss NA 50% Human Human +DTXSID9047126 Css NA 0.7176 mg/L 3compartmentss NA 95% Human Human +DTXSID9047126 Css NA 0.07143 mg/L PBTK NA 50% Human Human +DTXSID9047126 Css NA 0.4827 mg/L PBTK NA 95% Human Human +DTXSID9047126 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047126 Fup 0.234 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047126 Vd NA 1.096 L/kg 1compartment NA NA Rat Human DTXSID9047126 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047126 TK.Half.Life NA 0.5177 hours 1compartment NA NA Rat Human -DTXSID9047126 Css NA 0.01027 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047126 Css NA 0.06177 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047126 Css NA 0.007281 mg/L PBTK NA 50% Rat Human -DTXSID9047126 Css NA 0.0416 mg/L PBTK NA 95% Rat Human -DTXSID9047174 Clint NA 22.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047174 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047174 Vd NA 1.747 L/kg 1compartment NA NA Human Human +DTXSID9047126 TK.Half.Life NA 0.8718 hours 1compartment NA NA Rat Human +DTXSID9047126 Css NA 0.01242 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047126 Css NA 0.06549 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047126 Css NA 0.008997 mg/L PBTK NA 50% Rat Human +DTXSID9047126 Css NA 0.04419 mg/L PBTK NA 95% Rat Human +DTXSID9047174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047174 Fup 0.0725 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047174 Vd NA 2.528 L/kg 1compartment NA NA Human Human DTXSID9047174 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9047174 TK.Half.Life NA 16.08 hours 1compartment NA NA Human Human -DTXSID9047174 Css NA 1.408 mg/L 3compartmentss NA 50% Human Human -DTXSID9047174 Css NA 12.09 mg/L 3compartmentss NA 95% Human Human -DTXSID9047174 Css NA 0.8974 mg/L PBTK NA 50% Human Human -DTXSID9047174 Css NA 7.391 mg/L PBTK NA 95% Human Human -DTXSID9047174 Clint NA 22.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047174 Fup NA 0.0203 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047174 Vd NA 1.297 L/kg 1compartment NA NA Rat Human +DTXSID9047174 TK.Half.Life NA 14.32 hours 1compartment NA NA Human Human +DTXSID9047174 Css NA 0.6736 mg/L 3compartmentss NA 50% Human Human +DTXSID9047174 Css NA 4.359 mg/L 3compartmentss NA 95% Human Human +DTXSID9047174 Css NA 0.456 mg/L PBTK NA 50% Human Human +DTXSID9047174 Css NA 2.871 mg/L PBTK NA 95% Human Human +DTXSID9047174 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047174 Fup 0.0725 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047174 Vd NA 1.898 L/kg 1compartment NA NA Rat Human DTXSID9047174 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047174 TK.Half.Life NA 5.71 hours 1compartment NA NA Rat Human -DTXSID9047174 Css NA 0.793 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047174 Css NA 5.376 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047174 Css NA 0.4732 mg/L PBTK NA 50% Rat Human -DTXSID9047174 Css NA 3.054 mg/L PBTK NA 95% Rat Human -DTXSID9047178 Clint NA 436.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047178 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047178 Vd NA 1612 L/kg 1compartment NA NA Human Human -DTXSID9047178 Days.Css NA 618 Days PBTK NA NA Human Human -DTXSID9047178 TK.Half.Life NA 2414 hours 1compartment NA NA Human Human -DTXSID9047178 Css NA 0.0004691 mg/L 3compartmentss NA 50% Human Human -DTXSID9047178 Css NA 0.002823 mg/L 3compartmentss NA 95% Human Human -DTXSID9047178 Css NA 0.1248 mg/L PBTK NA 50% Human Human -DTXSID9047178 Css NA 0.6872 mg/L PBTK NA 95% Human Human -DTXSID9047178 Clint NA 436.4 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047178 Fup NA 0.0044 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047178 Vd NA 1488 L/kg 1compartment NA NA Rat Human -DTXSID9047178 Days.Css NA 426 Days PBTK NA NA Rat Human -DTXSID9047178 TK.Half.Life NA 409.7 hours 1compartment NA NA Rat Human -DTXSID9047178 Css NA 0.0002362 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047178 Css NA 0.001054 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047178 Css NA 0.06776 mg/L PBTK NA 50% Rat Human -DTXSID9047178 Css NA 0.303 mg/L PBTK NA 95% Rat Human -DTXSID9047201 Clint NA 105.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047201 Fup NA 0.1975 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047201 Vd NA 1.353 L/kg 1compartment NA NA Human Human +DTXSID9047174 TK.Half.Life NA 3.623 hours 1compartment NA NA Rat Human +DTXSID9047174 Css NA 0.08681 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047174 Css NA 0.4654 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047174 Css NA 0.0582 mg/L PBTK NA 50% Rat Human +DTXSID9047174 Css NA 0.3023 mg/L PBTK NA 95% Rat Human +DTXSID9047201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047201 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047201 Vd NA 1.599 L/kg 1compartment NA NA Human Human DTXSID9047201 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047201 TK.Half.Life NA 1.33 hours 1compartment NA NA Human Human -DTXSID9047201 Css NA 0.02626 mg/L 3compartmentss NA 50% Human Human -DTXSID9047201 Css NA 0.1908 mg/L 3compartmentss NA 95% Human Human -DTXSID9047201 Css NA 0.01855 mg/L PBTK NA 50% Human Human -DTXSID9047201 Css NA 0.1279 mg/L PBTK NA 95% Human Human -DTXSID9047201 Clint NA 105.9 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047201 Fup NA 0.1975 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047201 Vd NA 1.077 L/kg 1compartment NA NA Rat Human +DTXSID9047201 TK.Half.Life NA 2.428 hours 1compartment NA NA Human Human +DTXSID9047201 Css NA 0.09302 mg/L 3compartmentss NA 50% Human Human +DTXSID9047201 Css NA 0.6475 mg/L 3compartmentss NA 95% Human Human +DTXSID9047201 Css NA 0.06913 mg/L PBTK NA 50% Human Human +DTXSID9047201 Css NA 0.455 mg/L PBTK NA 95% Human Human +DTXSID9047201 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047201 Fup 0.265 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047201 Vd NA 1.273 L/kg 1compartment NA NA Rat Human DTXSID9047201 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047201 TK.Half.Life NA 0.4916 hours 1compartment NA NA Rat Human -DTXSID9047201 Css NA 0.01458 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047201 Css NA 0.0867 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047201 Css NA 0.009932 mg/L PBTK NA 50% Rat Human -DTXSID9047201 Css NA 0.05664 mg/L PBTK NA 95% Rat Human -DTXSID9047203 Clint NA 42.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047203 Fup NA 0.2077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047203 Vd NA 1.601 L/kg 1compartment NA NA Human Human +DTXSID9047201 TK.Half.Life NA 0.9357 hours 1compartment NA NA Rat Human +DTXSID9047201 Css NA 0.0115 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047201 Css NA 0.06138 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047201 Css NA 0.008583 mg/L PBTK NA 50% Rat Human +DTXSID9047201 Css NA 0.04241 mg/L PBTK NA 95% Rat Human +DTXSID9047203 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047203 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047203 Vd NA 2.16 L/kg 1compartment NA NA Human Human DTXSID9047203 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047203 TK.Half.Life NA 2.06 hours 1compartment NA NA Human Human -DTXSID9047203 Css NA 0.06618 mg/L 3compartmentss NA 50% Human Human -DTXSID9047203 Css NA 0.4412 mg/L 3compartmentss NA 95% Human Human -DTXSID9047203 Css NA 0.04772 mg/L PBTK NA 50% Human Human -DTXSID9047203 Css NA 0.2984 mg/L PBTK NA 95% Human Human -DTXSID9047203 Clint NA 42.67 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047203 Fup NA 0.2077 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047203 Vd NA 1.258 L/kg 1compartment NA NA Rat Human +DTXSID9047203 TK.Half.Life NA 5.554 hours 1compartment NA NA Human Human +DTXSID9047203 Css NA 0.2357 mg/L 3compartmentss NA 50% Human Human +DTXSID9047203 Css NA 1.622 mg/L 3compartmentss NA 95% Human Human +DTXSID9047203 Css NA 0.1658 mg/L PBTK NA 50% Human Human +DTXSID9047203 Css NA 1.09 mg/L PBTK NA 95% Human Human +DTXSID9047203 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047203 Fup 0.158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047203 Vd NA 1.648 L/kg 1compartment NA NA Rat Human DTXSID9047203 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047203 TK.Half.Life NA 0.7669 hours 1compartment NA NA Rat Human -DTXSID9047203 Css NA 0.03617 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047203 Css NA 0.1996 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047203 Css NA 0.02499 mg/L PBTK NA 50% Rat Human -DTXSID9047203 Css NA 0.1308 mg/L PBTK NA 95% Rat Human -DTXSID9047205 Clint NA 64.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047205 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047205 Vd NA 3.023 L/kg 1compartment NA NA Human Human -DTXSID9047205 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9047205 TK.Half.Life NA 25.47 hours 1compartment NA NA Human Human -DTXSID9047205 Css NA 1.003 mg/L 3compartmentss NA 50% Human Human -DTXSID9047205 Css NA 6.293 mg/L 3compartmentss NA 95% Human Human -DTXSID9047205 Css NA 0.6914 mg/L PBTK NA 50% Human Human -DTXSID9047205 Css NA 4.207 mg/L PBTK NA 95% Human Human -DTXSID9047205 Clint NA 64.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047205 Fup NA 0.0145 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047205 Vd NA 2.263 L/kg 1compartment NA NA Rat Human -DTXSID9047205 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9047205 TK.Half.Life NA 4.211 hours 1compartment NA NA Rat Human -DTXSID9047205 Css NA 0.5619 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047205 Css NA 2.982 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047205 Css NA 0.3674 mg/L PBTK NA 50% Rat Human -DTXSID9047205 Css NA 1.92 mg/L PBTK NA 95% Rat Human +DTXSID9047203 TK.Half.Life NA 1.77 hours 1compartment NA NA Rat Human +DTXSID9047203 Css NA 0.02996 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047203 Css NA 0.1539 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047203 Css NA 0.02089 mg/L PBTK NA 50% Rat Human +DTXSID9047203 Css NA 0.1023 mg/L PBTK NA 95% Rat Human +DTXSID9047205 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047205 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047205 Vd NA 3.12 L/kg 1compartment NA NA Human Human +DTXSID9047205 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID9047205 TK.Half.Life NA 94.27 hours 1compartment NA NA Human Human +DTXSID9047205 Css NA 3.418 mg/L 3compartmentss NA 50% Human Human +DTXSID9047205 Css NA 20.59 mg/L 3compartmentss NA 95% Human Human +DTXSID9047205 Css NA 2.367 mg/L PBTK NA 50% Human Human +DTXSID9047205 Css NA 14.33 mg/L PBTK NA 95% Human Human +DTXSID9047205 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047205 Fup 0.0161 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047205 Vd NA 2.337 L/kg 1compartment NA NA Rat Human +DTXSID9047205 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID9047205 TK.Half.Life NA 12.63 hours 1compartment NA NA Rat Human +DTXSID9047205 Css NA 0.4472 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047205 Css NA 2.224 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047205 Css NA 0.3061 mg/L PBTK NA 50% Rat Human +DTXSID9047205 Css NA 1.555 mg/L PBTK NA 95% Rat Human DTXSID9047251 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9047251 Fup 0.07996 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9047251 Vd NA 1.858 L/kg 1compartment NA NA Human Human -DTXSID9047251 Days.Css NA 32 Days PBTK NA NA Human Human -DTXSID9047251 TK.Half.Life NA 152.3 hours 1compartment NA NA Human Human -DTXSID9047251 Css NA 9.622 mg/L 3compartmentss NA 50% Human Human -DTXSID9047251 Css NA 52.42 mg/L 3compartmentss NA 95% Human Human -DTXSID9047251 Css NA 7.945 mg/L PBTK NA 50% Human Human -DTXSID9047251 Css NA 34.66 mg/L PBTK NA 95% Human Human +DTXSID9047251 Vd NA 1.645 L/kg 1compartment NA NA Human Human +DTXSID9047251 Days.Css NA 28 Days PBTK NA NA Human Human +DTXSID9047251 TK.Half.Life NA 134.1 hours 1compartment NA NA Human Human +DTXSID9047251 Css NA 9.724 mg/L 3compartmentss NA 50% Human Human +DTXSID9047251 Css NA 52.02 mg/L 3compartmentss NA 95% Human Human +DTXSID9047251 Css NA 7.717 mg/L PBTK NA 50% Human Human +DTXSID9047251 Css NA 33.66 mg/L PBTK NA 95% Human Human DTXSID9047251 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9047251 Fup 0.07996 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID9047251 Vd NA 1.822 L/kg 1compartment NA NA Rat Human -DTXSID9047251 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID9047251 TK.Half.Life NA 50.41 hours 1compartment NA NA Rat Human -DTXSID9047251 Css NA 2.646 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047251 Css NA 12.76 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047251 Css NA 2.118 mg/L PBTK NA 50% Rat Human -DTXSID9047251 Css NA 7.793 mg/L PBTK NA 95% Rat Human -DTXSID9047253 Clint NA 1.599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047253 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047253 Vd NA 0.6674 L/kg 1compartment NA NA Human Human -DTXSID9047253 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID9047253 TK.Half.Life NA 69.34 hours 1compartment NA NA Human Human -DTXSID9047253 Css NA 18.53 mg/L 3compartmentss NA 50% Human Human -DTXSID9047253 Css NA 127 mg/L 3compartmentss NA 95% Human Human -DTXSID9047253 Css NA 11.12 mg/L PBTK NA 50% Human Human -DTXSID9047253 Css NA 73.42 mg/L PBTK NA 95% Human Human -DTXSID9047253 Clint NA 1.599 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047253 Fup NA 0.016 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047253 Vd NA 0.5036 L/kg 1compartment NA NA Rat Human -DTXSID9047253 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9047253 TK.Half.Life NA 27.7 hours 1compartment NA NA Rat Human -DTXSID9047253 Css NA 8.61 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047253 Css NA 48.51 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047253 Css NA 4.815 mg/L PBTK NA 50% Rat Human -DTXSID9047253 Css NA 26.5 mg/L PBTK NA 95% Rat Human -DTXSID9047255 Clint NA 26.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047255 Fup NA 0.0194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047255 Vd NA 1.026 L/kg 1compartment NA NA Human Human +DTXSID9047251 Vd NA 1.611 L/kg 1compartment NA NA Rat Human +DTXSID9047251 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID9047251 TK.Half.Life NA 44.52 hours 1compartment NA NA Rat Human +DTXSID9047251 Css NA 0.6207 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047251 Css NA 2.851 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047251 Css NA 0.4915 mg/L PBTK NA 50% Rat Human +DTXSID9047251 Css NA 1.778 mg/L PBTK NA 95% Rat Human +DTXSID9047253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047253 Fup 0.0273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047253 Vd NA 2.324 L/kg 1compartment NA NA Human Human +DTXSID9047253 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9047253 TK.Half.Life NA 21.94 hours 1compartment NA NA Human Human +DTXSID9047253 Css NA 1.291 mg/L 3compartmentss NA 50% Human Human +DTXSID9047253 Css NA 10.72 mg/L 3compartmentss NA 95% Human Human +DTXSID9047253 Css NA 0.8514 mg/L PBTK NA 50% Human Human +DTXSID9047253 Css NA 6.745 mg/L PBTK NA 95% Human Human +DTXSID9047253 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047253 Fup 0.0273 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047253 Vd NA 1.733 L/kg 1compartment NA NA Rat Human +DTXSID9047253 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9047253 TK.Half.Life NA 6.054 hours 1compartment NA NA Rat Human +DTXSID9047253 Css NA 0.1698 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047253 Css NA 1.071 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047253 Css NA 0.1096 mg/L PBTK NA 50% Rat Human +DTXSID9047253 Css NA 0.6588 mg/L PBTK NA 95% Rat Human +DTXSID9047255 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047255 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047255 Vd NA 1.258 L/kg 1compartment NA NA Human Human DTXSID9047255 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047255 TK.Half.Life NA 7.764 hours 1compartment NA NA Human Human -DTXSID9047255 Css NA 1.229 mg/L 3compartmentss NA 50% Human Human -DTXSID9047255 Css NA 11.8 mg/L 3compartmentss NA 95% Human Human -DTXSID9047255 Css NA 0.7486 mg/L PBTK NA 50% Human Human -DTXSID9047255 Css NA 6.973 mg/L PBTK NA 95% Human Human -DTXSID9047255 Clint NA 26.72 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047255 Fup NA 0.0194 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047255 Vd NA 0.7619 L/kg 1compartment NA NA Rat Human +DTXSID9047255 TK.Half.Life NA 7.999 hours 1compartment NA NA Human Human +DTXSID9047255 Css NA 0.9641 mg/L 3compartmentss NA 50% Human Human +DTXSID9047255 Css NA 8.66 mg/L 3compartmentss NA 95% Human Human +DTXSID9047255 Css NA 0.5956 mg/L PBTK NA 50% Human Human +DTXSID9047255 Css NA 5.231 mg/L PBTK NA 95% Human Human +DTXSID9047255 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047255 Fup 0.0316 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047255 Vd NA 0.938 L/kg 1compartment NA NA Rat Human DTXSID9047255 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047255 TK.Half.Life NA 3.37 hours 1compartment NA NA Rat Human -DTXSID9047255 Css NA 0.6904 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047255 Css NA 5.235 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047255 Css NA 0.3929 mg/L PBTK NA 50% Rat Human -DTXSID9047255 Css NA 2.872 mg/L PBTK NA 95% Rat Human +DTXSID9047255 TK.Half.Life NA 3.277 hours 1compartment NA NA Rat Human +DTXSID9047255 Css NA 0.1238 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047255 Css NA 0.8544 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047255 Css NA 0.075 mg/L PBTK NA 50% Rat Human +DTXSID9047255 Css NA 0.4984 mg/L PBTK NA 95% Rat Human DTXSID9047257 Clint 17.11 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9047257 Fup 0.002114 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9047257 Vd NA 2.768 L/kg 1compartment NA NA Human Human -DTXSID9047257 Days.Css NA 18 Days PBTK NA NA Human Human -DTXSID9047257 TK.Half.Life NA 107.3 hours 1compartment NA NA Human Human -DTXSID9047257 Css NA 5.45 mg/L 3compartmentss NA 50% Human Human -DTXSID9047257 Css NA 36.68 mg/L 3compartmentss NA 95% Human Human -DTXSID9047257 Css NA 3.662 mg/L PBTK NA 50% Human Human -DTXSID9047257 Css NA 23.59 mg/L PBTK NA 95% Human Human +DTXSID9047257 Vd NA 4.16 L/kg 1compartment NA NA Human Human +DTXSID9047257 Days.Css NA 30 Days PBTK NA NA Human Human +DTXSID9047257 TK.Half.Life NA 163.6 hours 1compartment NA NA Human Human +DTXSID9047257 Css NA 4.58 mg/L 3compartmentss NA 50% Human Human +DTXSID9047257 Css NA 29.54 mg/L 3compartmentss NA 95% Human Human +DTXSID9047257 Css NA 3.422 mg/L PBTK NA 50% Human Human +DTXSID9047257 Css NA 21.03 mg/L PBTK NA 95% Human Human DTXSID9047257 Clint 17.11 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9047257 Fup 0.002114 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID9047257 Vd NA 2.07 L/kg 1compartment NA NA Rat Human -DTXSID9047257 Days.Css NA 10 Days PBTK NA NA Rat Human -DTXSID9047257 TK.Half.Life NA 21.42 hours 1compartment NA NA Rat Human -DTXSID9047257 Css NA 3.036 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047257 Css NA 15.34 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047257 Css NA 1.937 mg/L PBTK NA 50% Rat Human -DTXSID9047257 Css NA 9.556 mg/L PBTK NA 95% Rat Human -DTXSID9047259 Clint NA 4.611 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047259 Fup NA 0.0625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047259 Vd NA 2.061 L/kg 1compartment NA NA Human Human -DTXSID9047259 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9047259 TK.Half.Life NA 20.7 hours 1compartment NA NA Human Human -DTXSID9047259 Css NA 1.327 mg/L 3compartmentss NA 50% Human Human -DTXSID9047259 Css NA 9.43 mg/L 3compartmentss NA 95% Human Human -DTXSID9047259 Css NA 0.9906 mg/L PBTK NA 50% Human Human -DTXSID9047259 Css NA 6.218 mg/L PBTK NA 95% Human Human -DTXSID9047259 Clint NA 4.611 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047259 Fup NA 0.0625 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047259 Vd NA 1.885 L/kg 1compartment NA NA Rat Human -DTXSID9047259 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9047259 TK.Half.Life NA 10.57 hours 1compartment NA NA Rat Human -DTXSID9047259 Css NA 0.7011 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047259 Css NA 3.645 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047259 Css NA 0.4961 mg/L PBTK NA 50% Rat Human -DTXSID9047259 Css NA 2.224 mg/L PBTK NA 95% Rat Human -DTXSID9047330 Clint NA 15.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047330 Fup NA 0.0289 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047330 Vd NA 1.063 L/kg 1compartment NA NA Human Human -DTXSID9047330 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047330 TK.Half.Life NA 9.328 hours 1compartment NA NA Human Human -DTXSID9047330 Css NA 1.433 mg/L 3compartmentss NA 50% Human Human -DTXSID9047330 Css NA 12.6 mg/L 3compartmentss NA 95% Human Human -DTXSID9047330 Css NA 0.8828 mg/L PBTK NA 50% Human Human -DTXSID9047330 Css NA 7.472 mg/L PBTK NA 95% Human Human -DTXSID9047330 Clint NA 15.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047330 Fup NA 0.0289 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047330 Vd NA 0.7974 L/kg 1compartment NA NA Rat Human +DTXSID9047257 Vd NA 3.155 L/kg 1compartment NA NA Rat Human +DTXSID9047257 Days.Css NA 17 Days PBTK NA NA Rat Human +DTXSID9047257 TK.Half.Life NA 28.38 hours 1compartment NA NA Rat Human +DTXSID9047257 Css NA 0.6002 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047257 Css NA 3.05 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047257 Css NA 0.4477 mg/L PBTK NA 50% Rat Human +DTXSID9047257 Css NA 2.269 mg/L PBTK NA 95% Rat Human +DTXSID9047259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047259 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047259 Vd NA 3.247 L/kg 1compartment NA NA Human Human +DTXSID9047259 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9047259 TK.Half.Life NA 4.168 hours 1compartment NA NA Human Human +DTXSID9047259 Css NA 0.06515 mg/L 3compartmentss NA 50% Human Human +DTXSID9047259 Css NA 0.4902 mg/L 3compartmentss NA 95% Human Human +DTXSID9047259 Css NA 0.06572 mg/L PBTK NA 50% Human Human +DTXSID9047259 Css NA 0.4306 mg/L PBTK NA 95% Human Human +DTXSID9047259 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047259 Fup 0.212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047259 Vd NA 3.15 L/kg 1compartment NA NA Rat Human +DTXSID9047259 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9047259 TK.Half.Life NA 2.128 hours 1compartment NA NA Rat Human +DTXSID9047259 Css NA 0.007828 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047259 Css NA 0.04682 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047259 Css NA 0.008214 mg/L PBTK NA 50% Rat Human +DTXSID9047259 Css NA 0.04222 mg/L PBTK NA 95% Rat Human +DTXSID9047330 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047330 Fup 0.0678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047330 Vd NA 1.458 L/kg 1compartment NA NA Human Human +DTXSID9047330 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9047330 TK.Half.Life NA 14.99 hours 1compartment NA NA Human Human +DTXSID9047330 Css NA 1.522 mg/L 3compartmentss NA 50% Human Human +DTXSID9047330 Css NA 10.02 mg/L 3compartmentss NA 95% Human Human +DTXSID9047330 Css NA 0.9888 mg/L PBTK NA 50% Human Human +DTXSID9047330 Css NA 6.232 mg/L PBTK NA 95% Human Human +DTXSID9047330 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047330 Fup 0.0678 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047330 Vd NA 1.105 L/kg 1compartment NA NA Rat Human DTXSID9047330 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047330 TK.Half.Life NA 4.039 hours 1compartment NA NA Rat Human -DTXSID9047330 Css NA 0.8155 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047330 Css NA 5.52 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047330 Css NA 0.4696 mg/L PBTK NA 50% Rat Human -DTXSID9047330 Css NA 3.069 mg/L PBTK NA 95% Rat Human -DTXSID9047334 Clint NA 7.337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047334 Fup NA 0.1692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047334 Vd NA 2.035 L/kg 1compartment NA NA Human Human -DTXSID9047334 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047334 TK.Half.Life NA 7.969 hours 1compartment NA NA Human Human -DTXSID9047334 Css NA 0.3647 mg/L 3compartmentss NA 50% Human Human -DTXSID9047334 Css NA 2.231 mg/L 3compartmentss NA 95% Human Human -DTXSID9047334 Css NA 0.2895 mg/L PBTK NA 50% Human Human -DTXSID9047334 Css NA 1.611 mg/L PBTK NA 95% Human Human -DTXSID9047334 Clint NA 7.337 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047334 Fup NA 0.1692 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047334 Vd NA 1.808 L/kg 1compartment NA NA Rat Human -DTXSID9047334 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047334 TK.Half.Life NA 3.725 hours 1compartment NA NA Rat Human -DTXSID9047334 Css NA 0.1908 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047334 Css NA 0.8275 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047334 Css NA 0.1451 mg/L PBTK NA 50% Rat Human -DTXSID9047334 Css NA 0.5573 mg/L PBTK NA 95% Rat Human -DTXSID9047338 Clint NA 16.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047338 Fup NA 0.0354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047338 Vd NA 1.544 L/kg 1compartment NA NA Human Human +DTXSID9047330 TK.Half.Life NA 5.752 hours 1compartment NA NA Rat Human +DTXSID9047330 Css NA 0.188 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047330 Css NA 0.8842 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047330 Css NA 0.1184 mg/L PBTK NA 50% Rat Human +DTXSID9047330 Css NA 0.5226 mg/L PBTK NA 95% Rat Human +DTXSID9047334 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047334 Fup 0.0701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047334 Vd NA 1.887 L/kg 1compartment NA NA Human Human +DTXSID9047334 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9047334 TK.Half.Life NA 21.86 hours 1compartment NA NA Human Human +DTXSID9047334 Css NA 1.628 mg/L 3compartmentss NA 50% Human Human +DTXSID9047334 Css NA 9.046 mg/L 3compartmentss NA 95% Human Human +DTXSID9047334 Css NA 1.07 mg/L PBTK NA 50% Human Human +DTXSID9047334 Css NA 5.763 mg/L PBTK NA 95% Human Human +DTXSID9047334 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047334 Fup 0.0701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047334 Vd NA 1.421 L/kg 1compartment NA NA Rat Human +DTXSID9047334 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9047334 TK.Half.Life NA 7.211 hours 1compartment NA NA Rat Human +DTXSID9047334 Css NA 0.1978 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047334 Css NA 0.8551 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047334 Css NA 0.1286 mg/L PBTK NA 50% Rat Human +DTXSID9047334 Css NA 0.5232 mg/L PBTK NA 95% Rat Human +DTXSID9047338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047338 Fup 0.0573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047338 Vd NA 1.635 L/kg 1compartment NA NA Human Human DTXSID9047338 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047338 TK.Half.Life NA 12.24 hours 1compartment NA NA Human Human -DTXSID9047338 Css NA 1.204 mg/L 3compartmentss NA 50% Human Human -DTXSID9047338 Css NA 8.138 mg/L 3compartmentss NA 95% Human Human -DTXSID9047338 Css NA 0.7577 mg/L PBTK NA 50% Human Human -DTXSID9047338 Css NA 5.096 mg/L PBTK NA 95% Human Human -DTXSID9047338 Clint NA 16.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047338 Fup NA 0.0354 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047338 Vd NA 1.152 L/kg 1compartment NA NA Rat Human +DTXSID9047338 TK.Half.Life NA 7.191 hours 1compartment NA NA Human Human +DTXSID9047338 Css NA 0.5615 mg/L 3compartmentss NA 50% Human Human +DTXSID9047338 Css NA 4.123 mg/L 3compartmentss NA 95% Human Human +DTXSID9047338 Css NA 0.3636 mg/L PBTK NA 50% Human Human +DTXSID9047338 Css NA 2.58 mg/L PBTK NA 95% Human Human +DTXSID9047338 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047338 Fup 0.0573 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047338 Vd NA 1.228 L/kg 1compartment NA NA Rat Human DTXSID9047338 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047338 TK.Half.Life NA 4.64 hours 1compartment NA NA Rat Human -DTXSID9047338 Css NA 0.6678 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047338 Css NA 3.514 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047338 Css NA 0.3972 mg/L PBTK NA 50% Rat Human -DTXSID9047338 Css NA 2.025 mg/L PBTK NA 95% Rat Human -DTXSID9047411 Clint NA 18.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047411 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047411 Vd NA 2.141 L/kg 1compartment NA NA Human Human -DTXSID9047411 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9047411 TK.Half.Life NA 26.59 hours 1compartment NA NA Human Human -DTXSID9047411 Css NA 1.895 mg/L 3compartmentss NA 50% Human Human -DTXSID9047411 Css NA 15.19 mg/L 3compartmentss NA 95% Human Human -DTXSID9047411 Css NA 1.223 mg/L PBTK NA 50% Human Human -DTXSID9047411 Css NA 9.478 mg/L PBTK NA 95% Human Human -DTXSID9047411 Clint NA 18.99 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047411 Fup NA 0.019 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047411 Vd NA 1.593 L/kg 1compartment NA NA Rat Human -DTXSID9047411 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9047411 TK.Half.Life NA 8.007 hours 1compartment NA NA Rat Human -DTXSID9047411 Css NA 1.053 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047411 Css NA 6.573 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047411 Css NA 0.644 mg/L PBTK NA 50% Rat Human -DTXSID9047411 Css NA 3.814 mg/L PBTK NA 95% Rat Human -DTXSID9047415 Clint NA 21.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047415 Fup NA 0.1748 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047415 Vd NA 2.597 L/kg 1compartment NA NA Human Human +DTXSID9047338 TK.Half.Life NA 2.657 hours 1compartment NA NA Rat Human +DTXSID9047338 Css NA 0.07276 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047338 Css NA 0.4282 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047338 Css NA 0.04572 mg/L PBTK NA 50% Rat Human +DTXSID9047338 Css NA 0.2593 mg/L PBTK NA 95% Rat Human +DTXSID9047411 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047411 Fup 0.00664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047411 Vd NA 1.811 L/kg 1compartment NA NA Human Human +DTXSID9047411 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9047411 TK.Half.Life NA 35.27 hours 1compartment NA NA Human Human +DTXSID9047411 Css NA 3.124 mg/L 3compartmentss NA 50% Human Human +DTXSID9047411 Css NA 27.68 mg/L 3compartmentss NA 95% Human Human +DTXSID9047411 Css NA 1.955 mg/L PBTK NA 50% Human Human +DTXSID9047411 Css NA 16.75 mg/L PBTK NA 95% Human Human +DTXSID9047411 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047411 Fup 0.00664 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047411 Vd NA 1.337 L/kg 1compartment NA NA Rat Human +DTXSID9047411 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9047411 TK.Half.Life NA 12.2 hours 1compartment NA NA Rat Human +DTXSID9047411 Css NA 0.406 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047411 Css NA 2.881 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047411 Css NA 0.2482 mg/L PBTK NA 50% Rat Human +DTXSID9047411 Css NA 1.706 mg/L PBTK NA 95% Rat Human +DTXSID9047413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047413 Fup 0.0288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047413 Vd NA 3.125 L/kg 1compartment NA NA Human Human +DTXSID9047413 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID9047413 TK.Half.Life NA 90.82 hours 1compartment NA NA Human Human +DTXSID9047413 Css NA 3.381 mg/L 3compartmentss NA 50% Human Human +DTXSID9047413 Css NA 21.9 mg/L 3compartmentss NA 95% Human Human +DTXSID9047413 Css NA 2.34 mg/L PBTK NA 50% Human Human +DTXSID9047413 Css NA 14.76 mg/L PBTK NA 95% Human Human +DTXSID9047413 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047413 Fup 0.0288 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047413 Vd NA 2.34 L/kg 1compartment NA NA Rat Human +DTXSID9047413 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID9047413 TK.Half.Life NA 12.13 hours 1compartment NA NA Rat Human +DTXSID9047413 Css NA 0.4446 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047413 Css NA 2.257 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047413 Css NA 0.3051 mg/L PBTK NA 50% Rat Human +DTXSID9047413 Css NA 1.564 mg/L PBTK NA 95% Rat Human +DTXSID9047415 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047415 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047415 Vd NA 2.539 L/kg 1compartment NA NA Human Human DTXSID9047415 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047415 TK.Half.Life NA 8.588 hours 1compartment NA NA Human Human -DTXSID9047415 Css NA 0.3188 mg/L 3compartmentss NA 50% Human Human -DTXSID9047415 Css NA 1.944 mg/L 3compartmentss NA 95% Human Human -DTXSID9047415 Css NA 0.2274 mg/L PBTK NA 50% Human Human -DTXSID9047415 Css NA 1.322 mg/L PBTK NA 95% Human Human -DTXSID9047415 Clint NA 21.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047415 Fup NA 0.1748 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047415 Vd NA 1.97 L/kg 1compartment NA NA Rat Human +DTXSID9047415 TK.Half.Life NA 8.69 hours 1compartment NA NA Human Human +DTXSID9047415 Css NA 0.3409 mg/L 3compartmentss NA 50% Human Human +DTXSID9047415 Css NA 2.238 mg/L 3compartmentss NA 95% Human Human +DTXSID9047415 Css NA 0.2394 mg/L PBTK NA 50% Human Human +DTXSID9047415 Css NA 1.489 mg/L PBTK NA 95% Human Human +DTXSID9047415 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047415 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047415 Vd NA 1.923 L/kg 1compartment NA NA Rat Human DTXSID9047415 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047415 TK.Half.Life NA 2.21 hours 1compartment NA NA Rat Human -DTXSID9047415 Css NA 0.1739 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047415 Css NA 0.813 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047415 Css NA 0.1195 mg/L PBTK NA 50% Rat Human -DTXSID9047415 Css NA 0.5335 mg/L PBTK NA 95% Rat Human -DTXSID9047417 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047417 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047417 Vd NA 0.8741 L/kg 1compartment NA NA Human Human +DTXSID9047415 TK.Half.Life NA 2.293 hours 1compartment NA NA Rat Human +DTXSID9047415 Css NA 0.0438 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047415 Css NA 0.2302 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047415 Css NA 0.03052 mg/L PBTK NA 50% Rat Human +DTXSID9047415 Css NA 0.1535 mg/L PBTK NA 95% Rat Human +DTXSID9047417 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047417 Fup 0.68 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047417 Vd NA 0.7229 L/kg 1compartment NA NA Human Human DTXSID9047417 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047417 TK.Half.Life NA 5.672 hours 1compartment NA NA Human Human -DTXSID9047417 Css NA 0.8024 mg/L 3compartmentss NA 50% Human Human -DTXSID9047417 Css NA 5.406 mg/L 3compartmentss NA 95% Human Human -DTXSID9047417 Css NA 0.6962 mg/L PBTK NA 50% Human Human -DTXSID9047417 Css NA 3.602 mg/L PBTK NA 95% Human Human -DTXSID9047417 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047417 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047417 Vd NA 0.8972 L/kg 1compartment NA NA Rat Human +DTXSID9047417 TK.Half.Life NA 6.904 hours 1compartment NA NA Human Human +DTXSID9047417 Css NA 0.9428 mg/L 3compartmentss NA 50% Human Human +DTXSID9047417 Css NA 6.235 mg/L 3compartmentss NA 95% Human Human +DTXSID9047417 Css NA 0.7655 mg/L PBTK NA 50% Human Human +DTXSID9047417 Css NA 3.994 mg/L PBTK NA 95% Human Human +DTXSID9047417 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047417 Fup 0.68 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047417 Vd NA 0.7361 L/kg 1compartment NA NA Rat Human DTXSID9047417 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047417 TK.Half.Life NA 1.98 hours 1compartment NA NA Rat Human -DTXSID9047417 Css NA 0.2028 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047417 Css NA 1.234 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047417 Css NA 0.1723 mg/L PBTK NA 50% Rat Human -DTXSID9047417 Css NA 0.7541 mg/L PBTK NA 95% Rat Human -DTXSID9047461 Clint NA 2.693 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047461 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047461 Vd NA 1.115 L/kg 1compartment NA NA Human Human +DTXSID9047417 TK.Half.Life NA 2.389 hours 1compartment NA NA Rat Human +DTXSID9047417 Css NA 0.01798 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047417 Css NA 0.1491 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047417 Css NA 0.01396 mg/L PBTK NA 50% Rat Human +DTXSID9047417 Css NA 0.09585 mg/L PBTK NA 95% Rat Human +DTXSID9047419 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047419 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047419 Vd NA 1.578 L/kg 1compartment NA NA Human Human +DTXSID9047419 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9047419 TK.Half.Life NA 16.65 hours 1compartment NA NA Human Human +DTXSID9047419 Css NA 1.638 mg/L 3compartmentss NA 50% Human Human +DTXSID9047419 Css NA 14.74 mg/L 3compartmentss NA 95% Human Human +DTXSID9047419 Css NA 1.025 mg/L PBTK NA 50% Human Human +DTXSID9047419 Css NA 9.023 mg/L PBTK NA 95% Human Human +DTXSID9047419 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047419 Fup 0.0168 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047419 Vd NA 1.169 L/kg 1compartment NA NA Rat Human +DTXSID9047419 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9047419 TK.Half.Life NA 6.256 hours 1compartment NA NA Rat Human +DTXSID9047419 Css NA 0.2156 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047419 Css NA 1.511 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047419 Css NA 0.1306 mg/L PBTK NA 50% Rat Human +DTXSID9047419 Css NA 0.8939 mg/L PBTK NA 95% Rat Human +DTXSID9047461 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047461 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047461 Vd NA 0.9064 L/kg 1compartment NA NA Human Human DTXSID9047461 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047461 TK.Half.Life NA 1.723 hours 1compartment NA NA Human Human -DTXSID9047461 Css NA 0.1493 mg/L 3compartmentss NA 50% Human Human -DTXSID9047461 Css NA 1.176 mg/L 3compartmentss NA 95% Human Human -DTXSID9047461 Css NA 0.1324 mg/L PBTK NA 50% Human Human -DTXSID9047461 Css NA 0.8853 mg/L PBTK NA 95% Human Human -DTXSID9047461 Clint NA 2.693 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047461 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047461 Vd NA 1.124 L/kg 1compartment NA NA Rat Human +DTXSID9047461 TK.Half.Life NA 8.208 hours 1compartment NA NA Human Human +DTXSID9047461 Css NA 0.8836 mg/L 3compartmentss NA 50% Human Human +DTXSID9047461 Css NA 5.844 mg/L 3compartmentss NA 95% Human Human +DTXSID9047461 Css NA 0.7443 mg/L PBTK NA 50% Human Human +DTXSID9047461 Css NA 3.779 mg/L PBTK NA 95% Human Human +DTXSID9047461 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047461 Fup 0.719 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047461 Vd NA 0.9123 L/kg 1compartment NA NA Rat Human DTXSID9047461 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047461 TK.Half.Life NA 0.9047 hours 1compartment NA NA Rat Human -DTXSID9047461 Css NA 0.06346 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047461 Css NA 0.4529 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047461 Css NA 0.05647 mg/L PBTK NA 50% Rat Human -DTXSID9047461 Css NA 0.2808 mg/L PBTK NA 95% Rat Human -DTXSID9047467 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047467 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047467 Vd NA 0.7342 L/kg 1compartment NA NA Human Human -DTXSID9047467 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047467 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human -DTXSID9047467 Css NA 1.023 mg/L 3compartmentss NA 50% Human Human -DTXSID9047467 Css NA 6.515 mg/L 3compartmentss NA 95% Human Human -DTXSID9047467 Css NA 0.8344 mg/L PBTK NA 50% Human Human -DTXSID9047467 Css NA 4.14 mg/L PBTK NA 95% Human Human -DTXSID9047467 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047467 Fup NA 0.7667 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047467 Vd NA 0.7548 L/kg 1compartment NA NA Rat Human -DTXSID9047467 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047467 TK.Half.Life NA 2.172 hours 1compartment NA NA Rat Human -DTXSID9047467 Css NA 0.2618 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047467 Css NA 1.629 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047467 Css NA 0.208 mg/L PBTK NA 50% Rat Human -DTXSID9047467 Css NA 0.9689 mg/L PBTK NA 95% Rat Human +DTXSID9047461 TK.Half.Life NA 2.802 hours 1compartment NA NA Rat Human +DTXSID9047461 Css NA 0.01679 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047461 Css NA 0.1441 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047461 Css NA 0.01376 mg/L PBTK NA 50% Rat Human +DTXSID9047461 Css NA 0.09209 mg/L PBTK NA 95% Rat Human DTXSID9047540 Clint 20.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9047540 Fup 0.02488 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9047540 Vd NA 1.243 L/kg 1compartment NA NA Human Human +DTXSID9047540 Vd NA 1.256 L/kg 1compartment NA NA Human Human DTXSID9047540 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047540 TK.Half.Life NA 9.898 hours 1compartment NA NA Human Human -DTXSID9047540 Css NA 1.272 mg/L 3compartmentss NA 50% Human Human -DTXSID9047540 Css NA 11.33 mg/L 3compartmentss NA 95% Human Human -DTXSID9047540 Css NA 0.7876 mg/L PBTK NA 50% Human Human -DTXSID9047540 Css NA 6.716 mg/L PBTK NA 95% Human Human +DTXSID9047540 TK.Half.Life NA 10.01 hours 1compartment NA NA Human Human +DTXSID9047540 Css NA 1.245 mg/L 3compartmentss NA 50% Human Human +DTXSID9047540 Css NA 11.43 mg/L 3compartmentss NA 95% Human Human +DTXSID9047540 Css NA 0.7742 mg/L PBTK NA 50% Human Human +DTXSID9047540 Css NA 6.856 mg/L PBTK NA 95% Human Human DTXSID9047540 Clint 20.56 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9047540 Fup 0.02488 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID9047540 Vd NA 0.9261 L/kg 1compartment NA NA Rat Human +DTXSID9047540 Vd NA 0.9354 L/kg 1compartment NA NA Rat Human DTXSID9047540 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047540 TK.Half.Life NA 4.097 hours 1compartment NA NA Rat Human -DTXSID9047540 Css NA 0.7091 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047540 Css NA 5.013 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047540 Css NA 0.4122 mg/L PBTK NA 50% Rat Human -DTXSID9047540 Css NA 2.801 mg/L PBTK NA 95% Rat Human +DTXSID9047540 TK.Half.Life NA 4.128 hours 1compartment NA NA Rat Human +DTXSID9047540 Css NA 0.1609 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047540 Css NA 1.166 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047540 Css NA 0.097 mg/L PBTK NA 50% Rat Human +DTXSID9047540 Css NA 0.6758 mg/L PBTK NA 95% Rat Human DTXSID9047542 Clint 57.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9047542 Fup NA 0.0185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047542 Vd NA 0.278 L/kg 1compartment NA NA Human Human +DTXSID9047542 Fup 0.0212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047542 Vd NA 0.2907 L/kg 1compartment NA NA Human Human DTXSID9047542 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047542 TK.Half.Life NA 1.266 hours 1compartment NA NA Human Human -DTXSID9047542 Css NA 0.6878 mg/L 3compartmentss NA 50% Human Human -DTXSID9047542 Css NA 7.075 mg/L 3compartmentss NA 95% Human Human -DTXSID9047542 Css NA 0.4165 mg/L PBTK NA 50% Human Human -DTXSID9047542 Css NA 4.131 mg/L PBTK NA 95% Human Human +DTXSID9047542 TK.Half.Life NA 1.188 hours 1compartment NA NA Human Human +DTXSID9047542 Css NA 0.5812 mg/L 3compartmentss NA 50% Human Human +DTXSID9047542 Css NA 5.9 mg/L 3compartmentss NA 95% Human Human +DTXSID9047542 Css NA 0.353 mg/L PBTK NA 50% Human Human +DTXSID9047542 Css NA 3.452 mg/L PBTK NA 95% Human Human DTXSID9047542 Clint 57.1 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9047542 Fup NA 0.0185 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047542 Vd NA 0.2682 L/kg 1compartment NA NA Rat Human +DTXSID9047542 Fup 0.0212 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047542 Vd NA 0.2806 L/kg 1compartment NA NA Rat Human DTXSID9047542 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047542 TK.Half.Life NA 0.7817 hours 1compartment NA NA Rat Human -DTXSID9047542 Css NA 0.3907 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047542 Css NA 3.358 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047542 Css NA 0.2192 mg/L PBTK NA 50% Rat Human -DTXSID9047542 Css NA 1.858 mg/L PBTK NA 95% Rat Human -DTXSID9047590 Clint NA 20.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047590 Fup NA 0.0366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047590 Vd NA 2.584 L/kg 1compartment NA NA Human Human -DTXSID9047590 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9047590 TK.Half.Life NA 24.67 hours 1compartment NA NA Human Human -DTXSID9047590 Css NA 1.31 mg/L 3compartmentss NA 50% Human Human -DTXSID9047590 Css NA 8.68 mg/L 3compartmentss NA 95% Human Human -DTXSID9047590 Css NA 0.8804 mg/L PBTK NA 50% Human Human -DTXSID9047590 Css NA 5.548 mg/L PBTK NA 95% Human Human -DTXSID9047590 Clint NA 20.95 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047590 Fup NA 0.0366 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047590 Vd NA 1.933 L/kg 1compartment NA NA Rat Human +DTXSID9047542 TK.Half.Life NA 0.5138 hours 1compartment NA NA Rat Human +DTXSID9047542 Css NA 0.05041 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047542 Css NA 0.4375 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047542 Css NA 0.0296 mg/L PBTK NA 50% Rat Human +DTXSID9047542 Css NA 0.2489 mg/L PBTK NA 95% Rat Human +DTXSID9047548 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9047548 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9047548 Vd NA 204.9 L/kg 1compartment NA NA Human Human +DTXSID9047548 Days.Css NA 5901 Days PBTK NA NA Human Human +DTXSID9047548 TK.Half.Life NA 9763000 hours 1compartment NA NA Human Human +DTXSID9047548 Css NA 112.8 mg/L 3compartmentss NA 50% Human Human +DTXSID9047548 Css NA 309.6 mg/L 3compartmentss NA 95% Human Human +DTXSID9047548 Css NA 3129 mg/L PBTK NA 50% Human Human +DTXSID9047548 Css NA 6955 mg/L PBTK NA 95% Human Human +DTXSID9047548 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9047548 Fup NA 0.0156 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9047548 Vd NA 181.1 L/kg 1compartment NA NA Rat Human +DTXSID9047548 Days.Css NA 8526 Days PBTK NA NA Rat Human +DTXSID9047548 TK.Half.Life NA 719800 hours 1compartment NA NA Rat Human +DTXSID9047548 Css NA 1.684 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047548 Css NA 8.658 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047548 Css NA 50.52 mg/L PBTK NA 50% Rat Human +DTXSID9047548 Css NA 227 mg/L PBTK NA 95% Rat Human +DTXSID9047590 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047590 Fup 0.0123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047590 Vd NA 1.963 L/kg 1compartment NA NA Human Human +DTXSID9047590 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9047590 TK.Half.Life NA 27.01 hours 1compartment NA NA Human Human +DTXSID9047590 Css NA 2.117 mg/L 3compartmentss NA 50% Human Human +DTXSID9047590 Css NA 16.82 mg/L 3compartmentss NA 95% Human Human +DTXSID9047590 Css NA 1.351 mg/L PBTK NA 50% Human Human +DTXSID9047590 Css NA 10.4 mg/L PBTK NA 95% Human Human +DTXSID9047590 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047590 Fup 0.0123 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047590 Vd NA 1.455 L/kg 1compartment NA NA Rat Human DTXSID9047590 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9047590 TK.Half.Life NA 5.839 hours 1compartment NA NA Rat Human -DTXSID9047590 Css NA 0.7234 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047590 Css NA 3.949 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047590 Css NA 0.4612 mg/L PBTK NA 50% Rat Human -DTXSID9047590 Css NA 2.409 mg/L PBTK NA 95% Rat Human +DTXSID9047590 TK.Half.Life NA 8.793 hours 1compartment NA NA Rat Human +DTXSID9047590 Css NA 0.272 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047590 Css NA 1.813 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047590 Css NA 0.1698 mg/L PBTK NA 50% Rat Human +DTXSID9047590 Css NA 1.087 mg/L PBTK NA 95% Rat Human DTXSID9047592 Clint 20.98 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human DTXSID9047592 Fup 0.005435 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Human Human -DTXSID9047592 Vd NA 1.284 L/kg 1compartment NA NA Human Human +DTXSID9047592 Vd NA 1.07 L/kg 1compartment NA NA Human Human DTXSID9047592 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9047592 TK.Half.Life NA 30.07 hours 1compartment NA NA Human Human -DTXSID9047592 Css NA 4.088 mg/L 3compartmentss NA 50% Human Human -DTXSID9047592 Css NA 36.47 mg/L 3compartmentss NA 95% Human Human -DTXSID9047592 Css NA 2.495 mg/L PBTK NA 50% Human Human -DTXSID9047592 Css NA 21.49 mg/L PBTK NA 95% Human Human +DTXSID9047592 TK.Half.Life NA 25.89 hours 1compartment NA NA Human Human +DTXSID9047592 Css NA 4.229 mg/L 3compartmentss NA 50% Human Human +DTXSID9047592 Css NA 40.01 mg/L 3compartmentss NA 95% Human Human +DTXSID9047592 Css NA 2.548 mg/L PBTK NA 50% Human Human +DTXSID9047592 Css NA 23.42 mg/L PBTK NA 95% Human Human DTXSID9047592 Clint 20.98 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human DTXSID9047592 Fup 0.005435 NA NA https://doi.org/10.1093/toxsci/kfv171 NA Rat Human -DTXSID9047592 Vd NA 0.9425 L/kg 1compartment NA NA Rat Human +DTXSID9047592 Vd NA 0.7855 L/kg 1compartment NA NA Rat Human DTXSID9047592 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9047592 TK.Half.Life NA 12.34 hours 1compartment NA NA Rat Human -DTXSID9047592 Css NA 2.327 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047592 Css NA 16.93 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047592 Css NA 1.331 mg/L PBTK NA 50% Rat Human -DTXSID9047592 Css NA 9.435 mg/L PBTK NA 95% Rat Human -DTXSID9047594 Clint NA 15.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047594 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047594 Vd NA 0.2843 L/kg 1compartment NA NA Human Human +DTXSID9047592 TK.Half.Life NA 11.23 hours 1compartment NA NA Rat Human +DTXSID9047592 Css NA 0.554 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047592 Css NA 4.27 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047592 Css NA 0.3234 mg/L PBTK NA 50% Rat Human +DTXSID9047592 Css NA 2.417 mg/L PBTK NA 95% Rat Human +DTXSID9047594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047594 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047594 Vd NA 0.4693 L/kg 1compartment NA NA Human Human DTXSID9047594 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047594 TK.Half.Life NA 4.59 hours 1compartment NA NA Human Human -DTXSID9047594 Css NA 2.838 mg/L 3compartmentss NA 50% Human Human -DTXSID9047594 Css NA 27.5 mg/L 3compartmentss NA 95% Human Human -DTXSID9047594 Css NA 1.716 mg/L PBTK NA 50% Human Human -DTXSID9047594 Css NA 16.33 mg/L PBTK NA 95% Human Human -DTXSID9047594 Clint NA 15.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047594 Fup NA 0.0153 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047594 Vd NA 0.271 L/kg 1compartment NA NA Rat Human +DTXSID9047594 TK.Half.Life NA 1.042 hours 1compartment NA NA Human Human +DTXSID9047594 Css NA 0.215 mg/L 3compartmentss NA 50% Human Human +DTXSID9047594 Css NA 1.751 mg/L 3compartmentss NA 95% Human Human +DTXSID9047594 Css NA 0.1428 mg/L PBTK NA 50% Human Human +DTXSID9047594 Css NA 1.106 mg/L PBTK NA 95% Human Human +DTXSID9047594 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047594 Fup 0.122 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047594 Vd NA 0.4621 L/kg 1compartment NA NA Rat Human DTXSID9047594 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047594 TK.Half.Life NA 2.893 hours 1compartment NA NA Rat Human -DTXSID9047594 Css NA 1.591 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047594 Css NA 12.49 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047594 Css NA 0.8942 mg/L PBTK NA 50% Rat Human -DTXSID9047594 Css NA 6.836 mg/L PBTK NA 95% Rat Human -DTXSID9047598 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047598 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047598 Vd NA 1.182 L/kg 1compartment NA NA Human Human -DTXSID9047598 Days.Css NA 43 Days PBTK NA NA Human Human -DTXSID9047598 TK.Half.Life NA 196.3 hours 1compartment NA NA Human Human -DTXSID9047598 Css NA 25.91 mg/L 3compartmentss NA 50% Human Human -DTXSID9047598 Css NA 117.7 mg/L 3compartmentss NA 95% Human Human -DTXSID9047598 Css NA 16.32 mg/L PBTK NA 50% Human Human -DTXSID9047598 Css NA 69.91 mg/L PBTK NA 95% Human Human -DTXSID9047598 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047598 Fup NA 0.0482 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047598 Vd NA 0.8942 L/kg 1compartment NA NA Rat Human -DTXSID9047598 Days.Css NA 9 Days PBTK NA NA Rat Human -DTXSID9047598 TK.Half.Life NA 43.21 hours 1compartment NA NA Rat Human -DTXSID9047598 Css NA 7.257 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047598 Css NA 27.92 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047598 Css NA 4.283 mg/L PBTK NA 50% Rat Human -DTXSID9047598 Css NA 15.46 mg/L PBTK NA 95% Rat Human -DTXSID9047623 Clint NA 68.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047623 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047623 Vd NA 8.191 L/kg 1compartment NA NA Human Human -DTXSID9047623 Days.Css NA 12 Days PBTK NA NA Human Human -DTXSID9047623 TK.Half.Life NA 81.42 hours 1compartment NA NA Human Human -DTXSID9047623 Css NA 0.7515 mg/L 3compartmentss NA 50% Human Human -DTXSID9047623 Css NA 4.306 mg/L 3compartmentss NA 95% Human Human -DTXSID9047623 Css NA 0.7836 mg/L PBTK NA 50% Human Human -DTXSID9047623 Css NA 4.409 mg/L PBTK NA 95% Human Human -DTXSID9047623 Clint NA 68.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047623 Fup NA 0.01 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047623 Vd NA 6.391 L/kg 1compartment NA NA Rat Human -DTXSID9047623 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID9047623 TK.Half.Life NA 11.99 hours 1compartment NA NA Rat Human -DTXSID9047623 Css NA 0.4114 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047623 Css NA 1.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047623 Css NA 0.4243 mg/L PBTK NA 50% Rat Human -DTXSID9047623 Css NA 1.796 mg/L PBTK NA 95% Rat Human -DTXSID9047675 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047675 Fup NA 0.958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047675 Vd NA 1.13 L/kg 1compartment NA NA Human Human -DTXSID9047675 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047675 TK.Half.Life NA 7.86 hours 1compartment NA NA Human Human -DTXSID9047675 Css NA 0.7912 mg/L 3compartmentss NA 50% Human Human -DTXSID9047675 Css NA 2.889 mg/L 3compartmentss NA 95% Human Human -DTXSID9047675 Css NA 0.717 mg/L PBTK NA 50% Human Human -DTXSID9047675 Css NA 2.124 mg/L PBTK NA 95% Human Human -DTXSID9047675 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047675 Fup NA 0.958 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047675 Vd NA 1.099 L/kg 1compartment NA NA Rat Human -DTXSID9047675 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047675 TK.Half.Life NA 2.547 hours 1compartment NA NA Rat Human -DTXSID9047675 Css NA 0.2017 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047675 Css NA 0.6753 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047675 Css NA 0.1801 mg/L PBTK NA 50% Rat Human -DTXSID9047675 Css NA 0.4583 mg/L PBTK NA 95% Rat Human -DTXSID9047677 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047677 Fup NA 0.9684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047677 Vd NA 1.004 L/kg 1compartment NA NA Human Human +DTXSID9047594 TK.Half.Life NA 0.6022 hours 1compartment NA NA Rat Human +DTXSID9047594 Css NA 0.02763 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047594 Css NA 0.1816 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047594 Css NA 0.01814 mg/L PBTK NA 50% Rat Human +DTXSID9047594 Css NA 0.11 mg/L PBTK NA 95% Rat Human +DTXSID9047596 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047596 Fup 0.0715 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047596 Vd NA 2.335 L/kg 1compartment NA NA Human Human +DTXSID9047596 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9047596 TK.Half.Life NA 11.61 hours 1compartment NA NA Human Human +DTXSID9047596 Css NA 0.5711 mg/L 3compartmentss NA 50% Human Human +DTXSID9047596 Css NA 3.888 mg/L 3compartmentss NA 95% Human Human +DTXSID9047596 Css NA 0.3872 mg/L PBTK NA 50% Human Human +DTXSID9047596 Css NA 2.571 mg/L PBTK NA 95% Human Human +DTXSID9047596 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047596 Fup 0.0715 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047596 Vd NA 1.755 L/kg 1compartment NA NA Rat Human +DTXSID9047596 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9047596 TK.Half.Life NA 3.287 hours 1compartment NA NA Rat Human +DTXSID9047596 Css NA 0.07476 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047596 Css NA 0.3883 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047596 Css NA 0.04983 mg/L PBTK NA 50% Rat Human +DTXSID9047596 Css NA 0.2493 mg/L PBTK NA 95% Rat Human +DTXSID9047598 Clint 84.7 NA uL/min/million hepatocytes NA Black 2021 NA Human Human +DTXSID9047598 Fup 0.0361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047598 Vd NA 1.025 L/kg 1compartment NA NA Human Human +DTXSID9047598 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9047598 TK.Half.Life NA 2.185 hours 1compartment NA NA Human Human +DTXSID9047598 Css NA 0.2222 mg/L 3compartmentss NA 50% Human Human +DTXSID9047598 Css NA 1.852 mg/L 3compartmentss NA 95% Human Human +DTXSID9047598 Css NA 0.1368 mg/L PBTK NA 50% Human Human +DTXSID9047598 Css NA 1.116 mg/L PBTK NA 95% Human Human +DTXSID9047598 Clint 84.7 NA uL/min/million hepatocytes NA Black 2021 NA Rat Human +DTXSID9047598 Fup 0.0361 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047598 Vd NA 0.7737 L/kg 1compartment NA NA Rat Human +DTXSID9047598 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9047598 TK.Half.Life NA 0.9206 hours 1compartment NA NA Rat Human +DTXSID9047598 Css NA 0.03109 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047598 Css NA 0.2107 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047598 Css NA 0.01854 mg/L PBTK NA 50% Rat Human +DTXSID9047598 Css NA 0.1232 mg/L PBTK NA 95% Rat Human +DTXSID9047623 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047623 Fup 0.0158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047623 Vd NA 79.15 L/kg 1compartment NA NA Human Human +DTXSID9047623 Days.Css NA 604 Days PBTK NA NA Human Human +DTXSID9047623 TK.Half.Life NA 2331 hours 1compartment NA NA Human Human +DTXSID9047623 Css NA 0.1376 mg/L 3compartmentss NA 50% Human Human +DTXSID9047623 Css NA 0.9678 mg/L 3compartmentss NA 95% Human Human +DTXSID9047623 Css NA 1.29 mg/L PBTK NA 50% Human Human +DTXSID9047623 Css NA 8.33 mg/L PBTK NA 95% Human Human +DTXSID9047623 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047623 Fup 0.0158 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047623 Vd NA 67.87 L/kg 1compartment NA NA Rat Human +DTXSID9047623 Days.Css NA 374 Days PBTK NA NA Rat Human +DTXSID9047623 TK.Half.Life NA 344.3 hours 1compartment NA NA Rat Human +DTXSID9047623 Css NA 0.001385 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047623 Css NA 0.008465 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047623 Css NA 0.01383 mg/L PBTK NA 50% Rat Human +DTXSID9047623 Css NA 0.08257 mg/L PBTK NA 95% Rat Human +DTXSID9047673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047673 Fup 0.0743 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047673 Vd NA 2.153 L/kg 1compartment NA NA Human Human +DTXSID9047673 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9047673 TK.Half.Life NA 9.487 hours 1compartment NA NA Human Human +DTXSID9047673 Css NA 0.5242 mg/L 3compartmentss NA 50% Human Human +DTXSID9047673 Css NA 3.559 mg/L 3compartmentss NA 95% Human Human +DTXSID9047673 Css NA 0.3504 mg/L PBTK NA 50% Human Human +DTXSID9047673 Css NA 2.288 mg/L PBTK NA 95% Human Human +DTXSID9047673 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047673 Fup 0.0743 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047673 Vd NA 1.617 L/kg 1compartment NA NA Rat Human +DTXSID9047673 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9047673 TK.Half.Life NA 2.912 hours 1compartment NA NA Rat Human +DTXSID9047673 Css NA 0.06745 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047673 Css NA 0.3723 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047673 Css NA 0.04424 mg/L PBTK NA 50% Rat Human +DTXSID9047673 Css NA 0.235 mg/L PBTK NA 95% Rat Human +DTXSID9047677 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047677 Fup 0.764 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047677 Vd NA 0.9647 L/kg 1compartment NA NA Human Human DTXSID9047677 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047677 TK.Half.Life NA 6.796 hours 1compartment NA NA Human Human -DTXSID9047677 Css NA 0.8402 mg/L 3compartmentss NA 50% Human Human -DTXSID9047677 Css NA 4.911 mg/L 3compartmentss NA 95% Human Human -DTXSID9047677 Css NA 0.7418 mg/L PBTK NA 50% Human Human -DTXSID9047677 Css NA 3.265 mg/L PBTK NA 95% Human Human -DTXSID9047677 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047677 Fup NA 0.9684 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047677 Vd NA 1.002 L/kg 1compartment NA NA Rat Human +DTXSID9047677 TK.Half.Life NA 8.343 hours 1compartment NA NA Human Human +DTXSID9047677 Css NA 0.8304 mg/L 3compartmentss NA 50% Human Human +DTXSID9047677 Css NA 5.574 mg/L 3compartmentss NA 95% Human Human +DTXSID9047677 Css NA 0.7178 mg/L PBTK NA 50% Human Human +DTXSID9047677 Css NA 3.665 mg/L PBTK NA 95% Human Human +DTXSID9047677 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047677 Fup 0.764 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047677 Vd NA 0.9402 L/kg 1compartment NA NA Rat Human DTXSID9047677 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047677 TK.Half.Life NA 2.288 hours 1compartment NA NA Rat Human -DTXSID9047677 Css NA 0.2118 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047677 Css NA 1.233 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047677 Css NA 0.1828 mg/L PBTK NA 50% Rat Human -DTXSID9047677 Css NA 0.7617 mg/L PBTK NA 95% Rat Human -DTXSID9047700 Clint NA 6.048 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047700 Fup NA 0.4118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047700 Vd NA 2.006 L/kg 1compartment NA NA Human Human -DTXSID9047700 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047700 TK.Half.Life NA 5.373 hours 1compartment NA NA Human Human -DTXSID9047700 Css NA 0.2355 mg/L 3compartmentss NA 50% Human Human -DTXSID9047700 Css NA 1.339 mg/L 3compartmentss NA 95% Human Human -DTXSID9047700 Css NA 0.1882 mg/L PBTK NA 50% Human Human -DTXSID9047700 Css NA 0.9784 mg/L PBTK NA 95% Human Human -DTXSID9047700 Clint NA 6.048 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047700 Fup NA 0.4118 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047700 Vd NA 1.6 L/kg 1compartment NA NA Rat Human -DTXSID9047700 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047700 TK.Half.Life NA 1.871 hours 1compartment NA NA Rat Human -DTXSID9047700 Css NA 0.118 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047700 Css NA 0.5223 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047700 Css NA 0.09149 mg/L PBTK NA 50% Rat Human -DTXSID9047700 Css NA 0.3569 mg/L PBTK NA 95% Rat Human -DTXSID9047702 Clint NA 14.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047702 Fup NA 0.2065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047702 Vd NA 2.297 L/kg 1compartment NA NA Human Human +DTXSID9047677 TK.Half.Life NA 2.727 hours 1compartment NA NA Rat Human +DTXSID9047677 Css NA 0.01557 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047677 Css NA 0.127 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047677 Css NA 0.01308 mg/L PBTK NA 50% Rat Human +DTXSID9047677 Css NA 0.08489 mg/L PBTK NA 95% Rat Human +DTXSID9047702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047702 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047702 Vd NA 1.881 L/kg 1compartment NA NA Human Human DTXSID9047702 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047702 TK.Half.Life NA 6.938 hours 1compartment NA NA Human Human -DTXSID9047702 Css NA 0.2794 mg/L 3compartmentss NA 50% Human Human -DTXSID9047702 Css NA 1.686 mg/L 3compartmentss NA 95% Human Human -DTXSID9047702 Css NA 0.2026 mg/L PBTK NA 50% Human Human -DTXSID9047702 Css NA 1.167 mg/L PBTK NA 95% Human Human -DTXSID9047702 Clint NA 14.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047702 Fup NA 0.2065 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047702 Vd NA 1.758 L/kg 1compartment NA NA Rat Human +DTXSID9047702 TK.Half.Life NA 5.466 hours 1compartment NA NA Human Human +DTXSID9047702 Css NA 0.3014 mg/L 3compartmentss NA 50% Human Human +DTXSID9047702 Css NA 2.253 mg/L 3compartmentss NA 95% Human Human +DTXSID9047702 Css NA 0.2042 mg/L PBTK NA 50% Human Human +DTXSID9047702 Css NA 1.459 mg/L PBTK NA 95% Human Human +DTXSID9047702 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047702 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047702 Vd NA 1.431 L/kg 1compartment NA NA Rat Human DTXSID9047702 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047702 TK.Half.Life NA 2.085 hours 1compartment NA NA Rat Human -DTXSID9047702 Css NA 0.1495 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047702 Css NA 0.6991 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047702 Css NA 0.1048 mg/L PBTK NA 50% Rat Human -DTXSID9047702 Css NA 0.4593 mg/L PBTK NA 95% Rat Human -DTXSID9047704 Clint NA 3.803 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047704 Fup NA 0.3899 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047704 Vd NA 3.091 L/kg 1compartment NA NA Human Human -DTXSID9047704 Days.Css NA 15 Days PBTK NA NA Human Human -DTXSID9047704 TK.Half.Life NA 93.72 hours 1compartment NA NA Human Human -DTXSID9047704 Css NA 3.524 mg/L 3compartmentss NA 50% Human Human -DTXSID9047704 Css NA 17.29 mg/L 3compartmentss NA 95% Human Human -DTXSID9047704 Css NA 2.518 mg/L PBTK NA 50% Human Human -DTXSID9047704 Css NA 12.04 mg/L PBTK NA 95% Human Human -DTXSID9047704 Clint NA 3.803 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047704 Fup NA 0.3899 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047704 Vd NA 2.332 L/kg 1compartment NA NA Rat Human -DTXSID9047704 Days.Css NA 8 Days PBTK NA NA Rat Human -DTXSID9047704 TK.Half.Life NA 12.74 hours 1compartment NA NA Rat Human -DTXSID9047704 Css NA 1.842 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047704 Css NA 6.484 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047704 Css NA 1.268 mg/L PBTK NA 50% Rat Human -DTXSID9047704 Css NA 4.235 mg/L PBTK NA 95% Rat Human -DTXSID9047708 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047708 Fup NA 0.0237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047708 Vd NA 3.003 L/kg 1compartment NA NA Human Human -DTXSID9047708 Days.Css NA 3276 Days PBTK NA NA Human Human -DTXSID9047708 TK.Half.Life NA 12080 hours 1compartment NA NA Human Human -DTXSID9047708 Css NA 486.2 mg/L 3compartmentss NA 50% Human Human -DTXSID9047708 Css NA 1367 mg/L 3compartmentss NA 95% Human Human -DTXSID9047708 Css NA 334.1 mg/L PBTK NA 50% Human Human -DTXSID9047708 Css NA 879.7 mg/L PBTK NA 95% Human Human -DTXSID9047708 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047708 Fup NA 0.0237 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047708 Vd NA 2.248 L/kg 1compartment NA NA Rat Human -DTXSID9047708 Days.Css NA 651 Days PBTK NA NA Rat Human -DTXSID9047708 TK.Half.Life NA 893.9 hours 1compartment NA NA Rat Human -DTXSID9047708 Css NA 131.8 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047708 Css NA 311.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047708 Css NA 86.62 mg/L PBTK NA 50% Rat Human -DTXSID9047708 Css NA 185.4 mg/L PBTK NA 95% Rat Human -DTXSID9047831 Clint NA 2.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047831 Fup NA 0.0184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047831 Vd NA 1.309 L/kg 1compartment NA NA Human Human -DTXSID9047831 Days.Css NA 16 Days PBTK NA NA Human Human -DTXSID9047831 TK.Half.Life NA 88.01 hours 1compartment NA NA Human Human -DTXSID9047831 Css NA 11.24 mg/L 3compartmentss NA 50% Human Human -DTXSID9047831 Css NA 79.43 mg/L 3compartmentss NA 95% Human Human -DTXSID9047831 Css NA 7.11 mg/L PBTK NA 50% Human Human -DTXSID9047831 Css NA 47.3 mg/L PBTK NA 95% Human Human -DTXSID9047831 Clint NA 2.469 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047831 Fup NA 0.0184 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047831 Vd NA 0.9842 L/kg 1compartment NA NA Rat Human -DTXSID9047831 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID9047831 TK.Half.Life NA 32.94 hours 1compartment NA NA Rat Human -DTXSID9047831 Css NA 5.52 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047831 Css NA 31.56 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047831 Css NA 3.302 mg/L PBTK NA 50% Rat Human -DTXSID9047831 Css NA 17.55 mg/L PBTK NA 95% Rat Human -DTXSID9047833 Clint NA 63.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047833 Fup NA 0.0092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047833 Vd NA 2.97 L/kg 1compartment NA NA Human Human +DTXSID9047702 TK.Half.Life NA 1.897 hours 1compartment NA NA Rat Human +DTXSID9047702 Css NA 0.03886 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047702 Css NA 0.2181 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047702 Css NA 0.02599 mg/L PBTK NA 50% Rat Human +DTXSID9047702 Css NA 0.1383 mg/L PBTK NA 95% Rat Human +DTXSID9047704 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047704 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047704 Vd NA 2.732 L/kg 1compartment NA NA Human Human +DTXSID9047704 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9047704 TK.Half.Life NA 14.56 hours 1compartment NA NA Human Human +DTXSID9047704 Css NA 0.5926 mg/L 3compartmentss NA 50% Human Human +DTXSID9047704 Css NA 3.69 mg/L 3compartmentss NA 95% Human Human +DTXSID9047704 Css NA 0.4103 mg/L PBTK NA 50% Human Human +DTXSID9047704 Css NA 2.477 mg/L PBTK NA 95% Human Human +DTXSID9047704 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047704 Fup 0.108 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047704 Vd NA 2.057 L/kg 1compartment NA NA Rat Human +DTXSID9047704 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9047704 TK.Half.Life NA 3.265 hours 1compartment NA NA Rat Human +DTXSID9047704 Css NA 0.07568 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047704 Css NA 0.4188 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047704 Css NA 0.05192 mg/L PBTK NA 50% Rat Human +DTXSID9047704 Css NA 0.2717 mg/L PBTK NA 95% Rat Human +DTXSID9047833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047833 Fup 0.0492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047833 Vd NA 2.782 L/kg 1compartment NA NA Human Human DTXSID9047833 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9047833 TK.Half.Life NA 26.43 hours 1compartment NA NA Human Human -DTXSID9047833 Css NA 1.087 mg/L 3compartmentss NA 50% Human Human -DTXSID9047833 Css NA 6.94 mg/L 3compartmentss NA 95% Human Human -DTXSID9047833 Css NA 0.7452 mg/L PBTK NA 50% Human Human -DTXSID9047833 Css NA 4.566 mg/L PBTK NA 95% Human Human -DTXSID9047833 Clint NA 63.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047833 Fup NA 0.0092 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047833 Vd NA 2.222 L/kg 1compartment NA NA Rat Human +DTXSID9047833 TK.Half.Life NA 26.32 hours 1compartment NA NA Human Human +DTXSID9047833 Css NA 1.154 mg/L 3compartmentss NA 50% Human Human +DTXSID9047833 Css NA 7.816 mg/L 3compartmentss NA 95% Human Human +DTXSID9047833 Css NA 0.7852 mg/L PBTK NA 50% Human Human +DTXSID9047833 Css NA 5.129 mg/L PBTK NA 95% Human Human +DTXSID9047833 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047833 Fup 0.0492 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047833 Vd NA 2.086 L/kg 1compartment NA NA Rat Human DTXSID9047833 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9047833 TK.Half.Life NA 4.578 hours 1compartment NA NA Rat Human -DTXSID9047833 Css NA 0.6062 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047833 Css NA 3.389 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047833 Css NA 0.3959 mg/L PBTK NA 50% Rat Human -DTXSID9047833 Css NA 2.111 mg/L PBTK NA 95% Rat Human -DTXSID9047835 Clint NA 19.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047835 Fup NA 0.1452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047835 Vd NA 2.993 L/kg 1compartment NA NA Human Human +DTXSID9047833 TK.Half.Life NA 5.407 hours 1compartment NA NA Rat Human +DTXSID9047833 Css NA 0.1506 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047833 Css NA 0.8059 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047833 Css NA 0.1012 mg/L PBTK NA 50% Rat Human +DTXSID9047833 Css NA 0.5344 mg/L PBTK NA 95% Rat Human +DTXSID9047835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047835 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047835 Vd NA 0.9088 L/kg 1compartment NA NA Human Human DTXSID9047835 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047835 TK.Half.Life NA 8.104 hours 1compartment NA NA Human Human -DTXSID9047835 Css NA 0.2484 mg/L 3compartmentss NA 50% Human Human -DTXSID9047835 Css NA 1.745 mg/L 3compartmentss NA 95% Human Human -DTXSID9047835 Css NA 0.196 mg/L PBTK NA 50% Human Human -DTXSID9047835 Css NA 1.279 mg/L PBTK NA 95% Human Human -DTXSID9047835 Clint NA 19.75 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047835 Fup NA 0.1452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047835 Vd NA 2.5 L/kg 1compartment NA NA Rat Human +DTXSID9047835 TK.Half.Life NA 1.36 hours 1compartment NA NA Human Human +DTXSID9047835 Css NA 0.08992 mg/L 3compartmentss NA 50% Human Human +DTXSID9047835 Css NA 0.6443 mg/L 3compartmentss NA 95% Human Human +DTXSID9047835 Css NA 0.06518 mg/L PBTK NA 50% Human Human +DTXSID9047835 Css NA 0.4341 mg/L PBTK NA 95% Human Human +DTXSID9047835 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047835 Fup 0.225 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047835 Vd NA 0.9064 L/kg 1compartment NA NA Rat Human DTXSID9047835 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047835 TK.Half.Life NA 2.647 hours 1compartment NA NA Rat Human -DTXSID9047835 Css NA 0.1338 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047835 Css NA 0.7481 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047835 Css NA 0.103 mg/L PBTK NA 50% Rat Human -DTXSID9047835 Css NA 0.5257 mg/L PBTK NA 95% Rat Human -DTXSID9047837 Clint NA 104.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047837 Fup NA 0.0402 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047837 Vd NA 1.618 L/kg 1compartment NA NA Human Human +DTXSID9047835 TK.Half.Life NA 0.7491 hours 1compartment NA NA Rat Human +DTXSID9047835 Css NA 0.01135 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047835 Css NA 0.06211 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047835 Css NA 0.008165 mg/L PBTK NA 50% Rat Human +DTXSID9047835 Css NA 0.04145 mg/L PBTK NA 95% Rat Human +DTXSID9047837 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047837 Fup 0.0887 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047837 Vd NA 2.043 L/kg 1compartment NA NA Human Human DTXSID9047837 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047837 TK.Half.Life NA 3.048 hours 1compartment NA NA Human Human -DTXSID9047837 Css NA 0.1761 mg/L 3compartmentss NA 50% Human Human -DTXSID9047837 Css NA 1.537 mg/L 3compartmentss NA 95% Human Human -DTXSID9047837 Css NA 0.1125 mg/L PBTK NA 50% Human Human -DTXSID9047837 Css NA 0.951 mg/L PBTK NA 95% Human Human -DTXSID9047837 Clint NA 104.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047837 Fup NA 0.0402 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047837 Vd NA 1.211 L/kg 1compartment NA NA Rat Human +DTXSID9047837 TK.Half.Life NA 7.497 hours 1compartment NA NA Human Human +DTXSID9047837 Css NA 0.4135 mg/L 3compartmentss NA 50% Human Human +DTXSID9047837 Css NA 2.877 mg/L 3compartmentss NA 95% Human Human +DTXSID9047837 Css NA 0.2783 mg/L PBTK NA 50% Human Human +DTXSID9047837 Css NA 1.841 mg/L PBTK NA 95% Human Human +DTXSID9047837 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047837 Fup 0.0887 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047837 Vd NA 1.544 L/kg 1compartment NA NA Rat Human DTXSID9047837 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047837 TK.Half.Life NA 1.095 hours 1compartment NA NA Rat Human -DTXSID9047837 Css NA 0.09928 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047837 Css NA 0.731 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047837 Css NA 0.05968 mg/L PBTK NA 50% Rat Human -DTXSID9047837 Css NA 0.4214 mg/L PBTK NA 95% Rat Human -DTXSID9047839 Clint NA 44.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047839 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047839 Vd NA 2.719 L/kg 1compartment NA NA Human Human -DTXSID9047839 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9047839 TK.Half.Life NA 17.8 hours 1compartment NA NA Human Human -DTXSID9047839 Css NA 0.8434 mg/L 3compartmentss NA 50% Human Human -DTXSID9047839 Css NA 5.925 mg/L 3compartmentss NA 95% Human Human -DTXSID9047839 Css NA 0.5666 mg/L PBTK NA 50% Human Human -DTXSID9047839 Css NA 3.828 mg/L PBTK NA 95% Human Human -DTXSID9047839 Clint NA 44.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047839 Fup NA 0.0054 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047839 Vd NA 2.043 L/kg 1compartment NA NA Rat Human +DTXSID9047837 TK.Half.Life NA 2.442 hours 1compartment NA NA Rat Human +DTXSID9047837 Css NA 0.0538 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047837 Css NA 0.2994 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047837 Css NA 0.03563 mg/L PBTK NA 50% Rat Human +DTXSID9047837 Css NA 0.1881 mg/L PBTK NA 95% Rat Human +DTXSID9047839 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047839 Fup 0.0595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047839 Vd NA 0.5292 L/kg 1compartment NA NA Human Human +DTXSID9047839 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9047839 TK.Half.Life NA 5.386 hours 1compartment NA NA Human Human +DTXSID9047839 Css NA 1.606 mg/L 3compartmentss NA 50% Human Human +DTXSID9047839 Css NA 11.18 mg/L 3compartmentss NA 95% Human Human +DTXSID9047839 Css NA 0.9996 mg/L PBTK NA 50% Human Human +DTXSID9047839 Css NA 6.666 mg/L PBTK NA 95% Human Human +DTXSID9047839 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047839 Fup 0.0595 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047839 Vd NA 0.5139 L/kg 1compartment NA NA Rat Human DTXSID9047839 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047839 TK.Half.Life NA 4.063 hours 1compartment NA NA Rat Human -DTXSID9047839 Css NA 0.4735 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047839 Css NA 2.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047839 Css NA 0.302 mg/L PBTK NA 50% Rat Human -DTXSID9047839 Css NA 1.741 mg/L PBTK NA 95% Rat Human -DTXSID9047881 Clint NA 28.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047881 Fup NA 0.0452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047881 Vd NA 1.939 L/kg 1compartment NA NA Human Human +DTXSID9047839 TK.Half.Life NA 3.253 hours 1compartment NA NA Rat Human +DTXSID9047839 Css NA 0.1981 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047839 Css NA 1.003 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047839 Css NA 0.1192 mg/L PBTK NA 50% Rat Human +DTXSID9047839 Css NA 0.5776 mg/L PBTK NA 95% Rat Human +DTXSID9047881 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047881 Fup 0.0344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047881 Vd NA 1.579 L/kg 1compartment NA NA Human Human DTXSID9047881 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047881 TK.Half.Life NA 8.984 hours 1compartment NA NA Human Human -DTXSID9047881 Css NA 0.6056 mg/L 3compartmentss NA 50% Human Human -DTXSID9047881 Css NA 4.256 mg/L 3compartmentss NA 95% Human Human -DTXSID9047881 Css NA 0.394 mg/L PBTK NA 50% Human Human -DTXSID9047881 Css NA 2.673 mg/L PBTK NA 95% Human Human -DTXSID9047881 Clint NA 28.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047881 Fup NA 0.0452 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047881 Vd NA 1.451 L/kg 1compartment NA NA Rat Human +DTXSID9047881 TK.Half.Life NA 9.932 hours 1compartment NA NA Human Human +DTXSID9047881 Css NA 0.9268 mg/L 3compartmentss NA 50% Human Human +DTXSID9047881 Css NA 6.878 mg/L 3compartmentss NA 95% Human Human +DTXSID9047881 Css NA 0.5866 mg/L PBTK NA 50% Human Human +DTXSID9047881 Css NA 4.198 mg/L PBTK NA 95% Human Human +DTXSID9047881 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047881 Fup 0.0344 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047881 Vd NA 1.178 L/kg 1compartment NA NA Rat Human DTXSID9047881 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047881 TK.Half.Life NA 2.999 hours 1compartment NA NA Rat Human -DTXSID9047881 Css NA 0.3392 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047881 Css NA 1.884 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047881 Css NA 0.2087 mg/L PBTK NA 50% Rat Human -DTXSID9047881 Css NA 1.115 mg/L PBTK NA 95% Rat Human -DTXSID9047883 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047883 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047883 Vd NA 5.964 L/kg 1compartment NA NA Human Human -DTXSID9047883 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID9047883 TK.Half.Life NA 186500 hours 1compartment NA NA Human Human -DTXSID9047883 Css NA 2886 mg/L 3compartmentss NA 50% Human Human -DTXSID9047883 Css NA 7818 mg/L 3compartmentss NA 95% Human Human -DTXSID9047883 Css NA 2526 mg/L PBTK NA 50% Human Human -DTXSID9047883 Css NA 6015 mg/L PBTK NA 95% Human Human -DTXSID9047883 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047883 Fup NA 0.0083 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047883 Vd NA 4.589 L/kg 1compartment NA NA Rat Human -DTXSID9047883 Days.Css NA 5901 Days PBTK NA NA Rat Human -DTXSID9047883 TK.Half.Life NA 12590 hours 1compartment NA NA Rat Human -DTXSID9047883 Css NA 762.9 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047883 Css NA 1901 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047883 Css NA 654.8 mg/L PBTK NA 50% Rat Human -DTXSID9047883 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID9047885 Clint NA 17.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047885 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047885 Vd NA 2.609 L/kg 1compartment NA NA Human Human -DTXSID9047885 Days.Css NA 6 Days PBTK NA NA Human Human -DTXSID9047885 TK.Half.Life NA 50.08 hours 1compartment NA NA Human Human -DTXSID9047885 Css NA 2.778 mg/L 3compartmentss NA 50% Human Human -DTXSID9047885 Css NA 18.42 mg/L 3compartmentss NA 95% Human Human -DTXSID9047885 Css NA 1.852 mg/L PBTK NA 50% Human Human -DTXSID9047885 Css NA 11.99 mg/L PBTK NA 95% Human Human -DTXSID9047885 Clint NA 17.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047885 Fup NA 0.0147 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047885 Vd NA 1.947 L/kg 1compartment NA NA Rat Human -DTXSID9047885 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9047885 TK.Half.Life NA 11.31 hours 1compartment NA NA Rat Human -DTXSID9047885 Css NA 1.539 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047885 Css NA 8.508 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047885 Css NA 0.9698 mg/L PBTK NA 50% Rat Human -DTXSID9047885 Css NA 5.253 mg/L PBTK NA 95% Rat Human -DTXSID9047887 Clint NA 116.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047887 Fup NA 0.0587 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047887 Vd NA 1.785 L/kg 1compartment NA NA Human Human +DTXSID9047881 TK.Half.Life NA 3.735 hours 1compartment NA NA Rat Human +DTXSID9047881 Css NA 0.1205 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047881 Css NA 0.7077 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047881 Css NA 0.07406 mg/L PBTK NA 50% Rat Human +DTXSID9047881 Css NA 0.4218 mg/L PBTK NA 95% Rat Human +DTXSID9047883 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047883 Fup 0.00777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047883 Vd NA 7.722 L/kg 1compartment NA NA Human Human +DTXSID9047883 Days.Css NA 44 Days PBTK NA NA Human Human +DTXSID9047883 TK.Half.Life NA 225 hours 1compartment NA NA Human Human +DTXSID9047883 Css NA 2.432 mg/L 3compartmentss NA 50% Human Human +DTXSID9047883 Css NA 16.34 mg/L 3compartmentss NA 95% Human Human +DTXSID9047883 Css NA 2.428 mg/L PBTK NA 50% Human Human +DTXSID9047883 Css NA 15.5 mg/L PBTK NA 95% Human Human +DTXSID9047883 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047883 Fup 0.00777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047883 Vd NA 6.009 L/kg 1compartment NA NA Rat Human +DTXSID9047883 Days.Css NA 26 Days PBTK NA NA Rat Human +DTXSID9047883 TK.Half.Life NA 32.59 hours 1compartment NA NA Rat Human +DTXSID9047883 Css NA 0.308 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047883 Css NA 1.572 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047883 Css NA 0.3163 mg/L PBTK NA 50% Rat Human +DTXSID9047883 Css NA 1.578 mg/L PBTK NA 95% Rat Human +DTXSID9047885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047885 Fup 0.02 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047885 Vd NA 2.557 L/kg 1compartment NA NA Human Human +DTXSID9047885 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9047885 TK.Half.Life NA 32.93 hours 1compartment NA NA Human Human +DTXSID9047885 Css NA 1.767 mg/L 3compartmentss NA 50% Human Human +DTXSID9047885 Css NA 13.09 mg/L 3compartmentss NA 95% Human Human +DTXSID9047885 Css NA 1.176 mg/L PBTK NA 50% Human Human +DTXSID9047885 Css NA 8.455 mg/L PBTK NA 95% Human Human +DTXSID9047885 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047885 Fup 0.02 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047885 Vd NA 1.908 L/kg 1compartment NA NA Rat Human +DTXSID9047885 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9047885 TK.Half.Life NA 7.816 hours 1compartment NA NA Rat Human +DTXSID9047885 Css NA 0.2275 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047885 Css NA 1.411 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047885 Css NA 0.1484 mg/L PBTK NA 50% Rat Human +DTXSID9047885 Css NA 0.884 mg/L PBTK NA 95% Rat Human +DTXSID9047887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047887 Fup 0.0701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047887 Vd NA 2.189 L/kg 1compartment NA NA Human Human DTXSID9047887 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047887 TK.Half.Life NA 2.767 hours 1compartment NA NA Human Human -DTXSID9047887 Css NA 0.1124 mg/L 3compartmentss NA 50% Human Human -DTXSID9047887 Css NA 0.831 mg/L 3compartmentss NA 95% Human Human -DTXSID9047887 Css NA 0.07327 mg/L PBTK NA 50% Human Human -DTXSID9047887 Css NA 0.5203 mg/L PBTK NA 95% Human Human -DTXSID9047887 Clint NA 116.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047887 Fup NA 0.0587 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047887 Vd NA 1.341 L/kg 1compartment NA NA Rat Human +DTXSID9047887 TK.Half.Life NA 10.2 hours 1compartment NA NA Human Human +DTXSID9047887 Css NA 0.556 mg/L 3compartmentss NA 50% Human Human +DTXSID9047887 Css NA 3.618 mg/L 3compartmentss NA 95% Human Human +DTXSID9047887 Css NA 0.3722 mg/L PBTK NA 50% Human Human +DTXSID9047887 Css NA 2.323 mg/L PBTK NA 95% Human Human +DTXSID9047887 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047887 Fup 0.0701 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047887 Vd NA 1.645 L/kg 1compartment NA NA Rat Human DTXSID9047887 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047887 TK.Half.Life NA 0.9541 hours 1compartment NA NA Rat Human -DTXSID9047887 Css NA 0.06408 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047887 Css NA 0.399 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047887 Css NA 0.03937 mg/L PBTK NA 50% Rat Human -DTXSID9047887 Css NA 0.2393 mg/L PBTK NA 95% Rat Human -DTXSID9047889 Clint NA 0.009729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047889 Fup NA 0.6372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047889 Vd NA 0.4223 L/kg 1compartment NA NA Human Human -DTXSID9047889 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047889 TK.Half.Life NA 4.214 hours 1compartment NA NA Human Human -DTXSID9047889 Css NA 1.252 mg/L 3compartmentss NA 50% Human Human -DTXSID9047889 Css NA 7.915 mg/L 3compartmentss NA 95% Human Human -DTXSID9047889 Css NA 0.914 mg/L PBTK NA 50% Human Human -DTXSID9047889 Css NA 4.916 mg/L PBTK NA 95% Human Human -DTXSID9047889 Clint NA 0.009729 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047889 Fup NA 0.6372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047889 Vd NA 0.4402 L/kg 1compartment NA NA Rat Human -DTXSID9047889 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047889 TK.Half.Life NA 1.51 hours 1compartment NA NA Rat Human -DTXSID9047889 Css NA 0.3403 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047889 Css NA 1.972 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047889 Css NA 0.2353 mg/L PBTK NA 50% Rat Human -DTXSID9047889 Css NA 1.127 mg/L PBTK NA 95% Rat Human -DTXSID9047910 Clint NA 18.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047910 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047910 Vd NA 0.682 L/kg 1compartment NA NA Human Human -DTXSID9047910 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047910 TK.Half.Life NA 0.4965 hours 1compartment NA NA Human Human -DTXSID9047910 Css NA 0.02588 mg/L 3compartmentss NA 50% Human Human -DTXSID9047910 Css NA 0.3123 mg/L 3compartmentss NA 95% Human Human -DTXSID9047910 Css NA 0.0209 mg/L PBTK NA 50% Human Human -DTXSID9047910 Css NA 0.2305 mg/L PBTK NA 95% Human Human -DTXSID9047910 Clint NA 18.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047910 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047910 Vd NA 0.7355 L/kg 1compartment NA NA Rat Human -DTXSID9047910 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047910 TK.Half.Life NA 0.2546 hours 1compartment NA NA Rat Human -DTXSID9047910 Css NA 0.01306 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047910 Css NA 0.1223 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047910 Css NA 0.01038 mg/L PBTK NA 50% Rat Human -DTXSID9047910 Css NA 0.08457 mg/L PBTK NA 95% Rat Human -DTXSID9047918 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047918 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047918 Vd NA 3.157 L/kg 1compartment NA NA Human Human -DTXSID9047918 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047918 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human -DTXSID9047918 Css NA 0.3557 mg/L 3compartmentss NA 50% Human Human -DTXSID9047918 Css NA 2.326 mg/L 3compartmentss NA 95% Human Human -DTXSID9047918 Css NA 0.2508 mg/L PBTK NA 50% Human Human -DTXSID9047918 Css NA 1.568 mg/L PBTK NA 95% Human Human -DTXSID9047918 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047918 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047918 Vd NA 2.375 L/kg 1compartment NA NA Rat Human -DTXSID9047918 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047918 TK.Half.Life NA 2.005 hours 1compartment NA NA Rat Human -DTXSID9047918 Css NA 0.199 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047918 Css NA 1.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047918 Css NA 0.1344 mg/L PBTK NA 50% Rat Human -DTXSID9047918 Css NA 0.7061 mg/L PBTK NA 95% Rat Human -DTXSID9047960 Clint NA 16.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047960 Fup NA 0.0642 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047960 Vd NA 1.999 L/kg 1compartment NA NA Human Human +DTXSID9047887 TK.Half.Life NA 3.089 hours 1compartment NA NA Rat Human +DTXSID9047887 Css NA 0.07182 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047887 Css NA 0.3743 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047887 Css NA 0.04714 mg/L PBTK NA 50% Rat Human +DTXSID9047887 Css NA 0.235 mg/L PBTK NA 95% Rat Human +DTXSID9047960 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047960 Fup 0.0285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047960 Vd NA 1.454 L/kg 1compartment NA NA Human Human DTXSID9047960 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047960 TK.Half.Life NA 11.13 hours 1compartment NA NA Human Human -DTXSID9047960 Css NA 0.726 mg/L 3compartmentss NA 50% Human Human -DTXSID9047960 Css NA 4.992 mg/L 3compartmentss NA 95% Human Human -DTXSID9047960 Css NA 0.4832 mg/L PBTK NA 50% Human Human -DTXSID9047960 Css NA 3.168 mg/L PBTK NA 95% Human Human -DTXSID9047960 Clint NA 16.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047960 Fup NA 0.0642 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047960 Vd NA 1.502 L/kg 1compartment NA NA Rat Human +DTXSID9047960 TK.Half.Life NA 10.27 hours 1compartment NA NA Human Human +DTXSID9047960 Css NA 1.057 mg/L 3compartmentss NA 50% Human Human +DTXSID9047960 Css NA 9.494 mg/L 3compartmentss NA 95% Human Human +DTXSID9047960 Css NA 0.6644 mg/L PBTK NA 50% Human Human +DTXSID9047960 Css NA 5.825 mg/L PBTK NA 95% Human Human +DTXSID9047960 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047960 Fup 0.0285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047960 Vd NA 1.083 L/kg 1compartment NA NA Rat Human DTXSID9047960 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047960 TK.Half.Life NA 3.625 hours 1compartment NA NA Rat Human -DTXSID9047960 Css NA 0.4064 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047960 Css NA 2.215 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047960 Css NA 0.2551 mg/L PBTK NA 50% Rat Human -DTXSID9047960 Css NA 1.307 mg/L PBTK NA 95% Rat Human -DTXSID9047962 Clint NA 29.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047962 Fup NA 0.0568 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047962 Vd NA 2.181 L/kg 1compartment NA NA Human Human -DTXSID9047962 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047962 TK.Half.Life NA 9.252 hours 1compartment NA NA Human Human -DTXSID9047962 Css NA 0.5232 mg/L 3compartmentss NA 50% Human Human -DTXSID9047962 Css NA 3.623 mg/L 3compartmentss NA 95% Human Human -DTXSID9047962 Css NA 0.3474 mg/L PBTK NA 50% Human Human -DTXSID9047962 Css NA 2.295 mg/L PBTK NA 95% Human Human -DTXSID9047962 Clint NA 29.01 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047962 Fup NA 0.0568 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047962 Vd NA 1.635 L/kg 1compartment NA NA Rat Human +DTXSID9047960 TK.Half.Life NA 4.004 hours 1compartment NA NA Rat Human +DTXSID9047960 Css NA 0.1384 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047960 Css NA 0.9777 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047960 Css NA 0.08433 mg/L PBTK NA 50% Rat Human +DTXSID9047960 Css NA 0.5686 mg/L PBTK NA 95% Rat Human +DTXSID9047962 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047962 Fup 0.0208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9047962 Vd NA 1.513 L/kg 1compartment NA NA Human Human +DTXSID9047962 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9047962 TK.Half.Life NA 13.58 hours 1compartment NA NA Human Human +DTXSID9047962 Css NA 1.388 mg/L 3compartmentss NA 50% Human Human +DTXSID9047962 Css NA 12.69 mg/L 3compartmentss NA 95% Human Human +DTXSID9047962 Css NA 0.8674 mg/L PBTK NA 50% Human Human +DTXSID9047962 Css NA 7.64 mg/L PBTK NA 95% Human Human +DTXSID9047962 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047962 Fup 0.0208 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9047962 Vd NA 1.123 L/kg 1compartment NA NA Rat Human DTXSID9047962 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047962 TK.Half.Life NA 2.821 hours 1compartment NA NA Rat Human -DTXSID9047962 Css NA 0.2924 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047962 Css NA 1.636 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047962 Css NA 0.1842 mg/L PBTK NA 50% Rat Human -DTXSID9047962 Css NA 1.004 mg/L PBTK NA 95% Rat Human -DTXSID9047964 Clint NA 18.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047964 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047964 Vd NA 0.6638 L/kg 1compartment NA NA Human Human -DTXSID9047964 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9047964 TK.Half.Life NA 0.4712 hours 1compartment NA NA Human Human -DTXSID9047964 Css NA 0.02244 mg/L 3compartmentss NA 50% Human Human -DTXSID9047964 Css NA 0.2777 mg/L 3compartmentss NA 95% Human Human -DTXSID9047964 Css NA 0.01804 mg/L PBTK NA 50% Human Human -DTXSID9047964 Css NA 0.2041 mg/L PBTK NA 95% Human Human -DTXSID9047964 Clint NA 18.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047964 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047964 Vd NA 0.7212 L/kg 1compartment NA NA Rat Human -DTXSID9047964 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047964 TK.Half.Life NA 0.2407 hours 1compartment NA NA Rat Human -DTXSID9047964 Css NA 0.01137 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047964 Css NA 0.1085 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047964 Css NA 0.008982 mg/L PBTK NA 50% Rat Human -DTXSID9047964 Css NA 0.07611 mg/L PBTK NA 95% Rat Human -DTXSID9047966 Clint NA 71.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047966 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047966 Vd NA 56.55 L/kg 1compartment NA NA Human Human -DTXSID9047966 Days.Css NA 116 Days PBTK NA NA Human Human -DTXSID9047966 TK.Half.Life NA 523.1 hours 1compartment NA NA Human Human -DTXSID9047966 Css NA 0.1217 mg/L 3compartmentss NA 50% Human Human -DTXSID9047966 Css NA 0.7433 mg/L 3compartmentss NA 95% Human Human -DTXSID9047966 Css NA 0.7664 mg/L PBTK NA 50% Human Human -DTXSID9047966 Css NA 4.335 mg/L PBTK NA 95% Human Human -DTXSID9047966 Clint NA 71.11 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047966 Fup NA 0.0046 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047966 Vd NA 47.91 L/kg 1compartment NA NA Rat Human -DTXSID9047966 Days.Css NA 75 Days PBTK NA NA Rat Human -DTXSID9047966 TK.Half.Life NA 81.98 hours 1compartment NA NA Rat Human -DTXSID9047966 Css NA 0.06245 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047966 Css NA 0.2638 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047966 Css NA 0.4155 mg/L PBTK NA 50% Rat Human -DTXSID9047966 Css NA 1.762 mg/L PBTK NA 95% Rat Human -DTXSID9047968 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047968 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9047968 Vd NA 0.3902 L/kg 1compartment NA NA Human Human -DTXSID9047968 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9047968 TK.Half.Life NA 22.9 hours 1compartment NA NA Human Human -DTXSID9047968 Css NA 8.838 mg/L 3compartmentss NA 50% Human Human -DTXSID9047968 Css NA 41.1 mg/L 3compartmentss NA 95% Human Human -DTXSID9047968 Css NA 5.668 mg/L PBTK NA 50% Human Human -DTXSID9047968 Css NA 24.67 mg/L PBTK NA 95% Human Human -DTXSID9047968 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047968 Fup NA 0.1102 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9047968 Vd NA 0.3866 L/kg 1compartment NA NA Rat Human -DTXSID9047968 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9047968 TK.Half.Life NA 7.736 hours 1compartment NA NA Rat Human -DTXSID9047968 Css NA 2.464 mg/L 3compartmentss NA 50% Rat Human -DTXSID9047968 Css NA 9.845 mg/L 3compartmentss NA 95% Rat Human -DTXSID9047968 Css NA 1.485 mg/L PBTK NA 50% Rat Human -DTXSID9047968 Css NA 5.483 mg/L PBTK NA 95% Rat Human -DTXSID9048190 Clint NA 9.897 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048190 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048190 Vd NA 3.112 L/kg 1compartment NA NA Human Human -DTXSID9048190 Days.Css NA 38 Days PBTK NA NA Human Human -DTXSID9048190 TK.Half.Life NA 193.5 hours 1compartment NA NA Human Human -DTXSID9048190 Css NA 7.585 mg/L 3compartmentss NA 50% Human Human -DTXSID9048190 Css NA 48.63 mg/L 3compartmentss NA 95% Human Human -DTXSID9048190 Css NA 5.274 mg/L PBTK NA 50% Human Human -DTXSID9048190 Css NA 32.68 mg/L PBTK NA 95% Human Human -DTXSID9048190 Clint NA 9.897 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048190 Fup NA 0.0171 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048190 Vd NA 2.331 L/kg 1compartment NA NA Rat Human -DTXSID9048190 Days.Css NA 21 Days PBTK NA NA Rat Human -DTXSID9048190 TK.Half.Life NA 25.69 hours 1compartment NA NA Rat Human -DTXSID9048190 Css NA 4.3 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048190 Css NA 19.88 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048190 Css NA 2.854 mg/L PBTK NA 50% Rat Human -DTXSID9048190 Css NA 12.97 mg/L PBTK NA 95% Rat Human +DTXSID9047962 TK.Half.Life NA 5.212 hours 1compartment NA NA Rat Human +DTXSID9047962 Css NA 0.18 mg/L 3compartmentss NA 50% Rat Human +DTXSID9047962 Css NA 1.356 mg/L 3compartmentss NA 95% Rat Human +DTXSID9047962 Css NA 0.1097 mg/L PBTK NA 50% Rat Human +DTXSID9047962 Css NA 0.7803 mg/L PBTK NA 95% Rat Human +DTXSID9048190 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048190 Fup 0.0323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048190 Vd NA 3.707 L/kg 1compartment NA NA Human Human +DTXSID9048190 Days.Css NA 19 Days PBTK NA NA Human Human +DTXSID9048190 TK.Half.Life NA 111.4 hours 1compartment NA NA Human Human +DTXSID9048190 Css NA 3.206 mg/L 3compartmentss NA 50% Human Human +DTXSID9048190 Css NA 18.68 mg/L 3compartmentss NA 95% Human Human +DTXSID9048190 Css NA 2.349 mg/L PBTK NA 50% Human Human +DTXSID9048190 Css NA 13.69 mg/L PBTK NA 95% Human Human +DTXSID9048190 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048190 Fup 0.0323 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048190 Vd NA 2.796 L/kg 1compartment NA NA Rat Human +DTXSID9048190 Days.Css NA 11 Days PBTK NA NA Rat Human +DTXSID9048190 TK.Half.Life NA 14.83 hours 1compartment NA NA Rat Human +DTXSID9048190 Css NA 0.4228 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048190 Css NA 2.008 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048190 Css NA 0.3057 mg/L PBTK NA 50% Rat Human +DTXSID9048190 Css NA 1.489 mg/L PBTK NA 95% Rat Human +DTXSID9048194 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048194 Fup 0.0125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048194 Vd NA 2.159 L/kg 1compartment NA NA Human Human +DTXSID9048194 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9048194 TK.Half.Life NA 30.7 hours 1compartment NA NA Human Human +DTXSID9048194 Css NA 2.132 mg/L 3compartmentss NA 50% Human Human +DTXSID9048194 Css NA 16.63 mg/L 3compartmentss NA 95% Human Human +DTXSID9048194 Css NA 1.372 mg/L PBTK NA 50% Human Human +DTXSID9048194 Css NA 10.12 mg/L PBTK NA 95% Human Human +DTXSID9048194 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048194 Fup 0.0125 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048194 Vd NA 1.604 L/kg 1compartment NA NA Rat Human +DTXSID9048194 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9048194 TK.Half.Life NA 9.143 hours 1compartment NA NA Rat Human +DTXSID9048194 Css NA 0.2745 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048194 Css NA 1.876 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048194 Css NA 0.1738 mg/L PBTK NA 50% Rat Human +DTXSID9048194 Css NA 1.124 mg/L PBTK NA 95% Rat Human +DTXSID9048196 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048196 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048196 Vd NA 1.502 L/kg 1compartment NA NA Human Human +DTXSID9048196 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048196 TK.Half.Life NA 11.62 hours 1compartment NA NA Human Human +DTXSID9048196 Css NA 1.166 mg/L 3compartmentss NA 50% Human Human +DTXSID9048196 Css NA 10.14 mg/L 3compartmentss NA 95% Human Human +DTXSID9048196 Css NA 0.7331 mg/L PBTK NA 50% Human Human +DTXSID9048196 Css NA 6.098 mg/L PBTK NA 95% Human Human +DTXSID9048196 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048196 Fup 0.0255 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048196 Vd NA 1.115 L/kg 1compartment NA NA Rat Human +DTXSID9048196 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9048196 TK.Half.Life NA 4.449 hours 1compartment NA NA Rat Human +DTXSID9048196 Css NA 0.153 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048196 Css NA 1.085 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048196 Css NA 0.09354 mg/L PBTK NA 50% Rat Human +DTXSID9048196 Css NA 0.6324 mg/L PBTK NA 95% Rat Human DTXSID9048271 Clint NA 7.677 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9048271 Fup NA 0.0566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048271 Vd NA 1.995 L/kg 1compartment NA NA Human Human -DTXSID9048271 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9048271 TK.Half.Life NA 24.17 hours 1compartment NA NA Human Human -DTXSID9048271 Css NA 1.762 mg/L 3compartmentss NA 50% Human Human -DTXSID9048271 Css NA 11.12 mg/L 3compartmentss NA 95% Human Human -DTXSID9048271 Css NA 1.161 mg/L PBTK NA 50% Human Human -DTXSID9048271 Css NA 6.994 mg/L PBTK NA 95% Human Human +DTXSID9048271 Vd NA 0.4047 L/kg 1compartment NA NA Human Human +DTXSID9048271 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048271 TK.Half.Life NA 3.633 hours 1compartment NA NA Human Human +DTXSID9048271 Css NA 1.378 mg/L 3compartmentss NA 50% Human Human +DTXSID9048271 Css NA 9.914 mg/L 3compartmentss NA 95% Human Human +DTXSID9048271 Css NA 0.8766 mg/L PBTK NA 50% Human Human +DTXSID9048271 Css NA 5.963 mg/L PBTK NA 95% Human Human DTXSID9048271 Clint NA 7.677 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9048271 Fup NA 0.0566 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048271 Vd NA 1.496 L/kg 1compartment NA NA Rat Human -DTXSID9048271 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9048271 TK.Half.Life NA 7.653 hours 1compartment NA NA Rat Human -DTXSID9048271 Css NA 0.9576 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048271 Css NA 4.403 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048271 Css NA 0.594 mg/L PBTK NA 50% Rat Human -DTXSID9048271 Css NA 2.633 mg/L PBTK NA 95% Rat Human +DTXSID9048271 Vd NA 0.3811 L/kg 1compartment NA NA Rat Human +DTXSID9048271 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9048271 TK.Half.Life NA 2.146 hours 1compartment NA NA Rat Human +DTXSID9048271 Css NA 0.1699 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048271 Css NA 0.9496 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048271 Css NA 0.1054 mg/L PBTK NA 50% Rat Human +DTXSID9048271 Css NA 0.5519 mg/L PBTK NA 95% Rat Human +DTXSID9048437 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048437 Fup 0.95 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9048437 Vd NA 9.842 L/kg 1compartment NA NA Human Human +DTXSID9048437 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048437 TK.Half.Life NA 3.024 hours 1compartment NA NA Human Human +DTXSID9048437 Css NA 0.005669 mg/L 3compartmentss NA 50% Human Human +DTXSID9048437 Css NA 0.08968 mg/L 3compartmentss NA 95% Human Human +DTXSID9048437 Css NA 0.0144 mg/L PBTK NA 50% Human Human +DTXSID9048437 Css NA 0.1331 mg/L PBTK NA 95% Human Human +DTXSID9048437 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048437 Fup 0.95 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9048437 Vd NA 10.11 L/kg 1compartment NA NA Rat Human +DTXSID9048437 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9048437 TK.Half.Life NA 1.616 hours 1compartment NA NA Rat Human +DTXSID9048437 Css NA 0.0006391 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048437 Css NA 0.009056 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048437 Css NA 0.0018 mg/L PBTK NA 50% Rat Human +DTXSID9048437 Css NA 0.01372 mg/L PBTK NA 95% Rat Human +DTXSID9048483 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048483 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID9048483 Vd NA 3.233 L/kg 1compartment NA NA Human Human +DTXSID9048483 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9048483 TK.Half.Life NA 21.61 hours 1compartment NA NA Human Human +DTXSID9048483 Css NA 0.5333 mg/L 3compartmentss NA 50% Human Human +DTXSID9048483 Css NA 3.791 mg/L 3compartmentss NA 95% Human Human +DTXSID9048483 Css NA 0.636 mg/L PBTK NA 50% Human Human +DTXSID9048483 Css NA 2.87 mg/L PBTK NA 95% Human Human +DTXSID9048483 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048483 Fup 0.97 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID9048483 Vd NA 3.298 L/kg 1compartment NA NA Rat Human +DTXSID9048483 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9048483 TK.Half.Life NA 7.5 hours 1compartment NA NA Rat Human +DTXSID9048483 Css NA 0.0136 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048483 Css NA 0.1073 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048483 Css NA 0.01606 mg/L PBTK NA 50% Rat Human +DTXSID9048483 Css NA 0.08388 mg/L PBTK NA 95% Rat Human DTXSID9048510 Clint 7.69 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9048510 Fup 0.0142 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human DTXSID9048510 Vd NA 0.8926 L/kg 1compartment NA NA Human Human DTXSID9048510 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID9048510 TK.Half.Life NA 26.69 hours 1compartment NA NA Human Human -DTXSID9048510 Css NA 3.717 mg/L 3compartmentss NA 50% Human Human -DTXSID9048510 Css NA 24.04 mg/L 3compartmentss NA 95% Human Human -DTXSID9048510 Css NA 2.306 mg/L PBTK NA 50% Human Human -DTXSID9048510 Css NA 14.53 mg/L PBTK NA 95% Human Human +DTXSID9048510 Css NA 3.652 mg/L 3compartmentss NA 50% Human Human +DTXSID9048510 Css NA 24.5 mg/L 3compartmentss NA 95% Human Human +DTXSID9048510 Css NA 2.274 mg/L PBTK NA 50% Human Human +DTXSID9048510 Css NA 14.61 mg/L PBTK NA 95% Human Human DTXSID9048510 Clint 7.69 NA uL/min/million hepatocytes NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9048510 Fup 0.0142 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human DTXSID9048510 Vd NA 0.6706 L/kg 1compartment NA NA Rat Human DTXSID9048510 Days.Css NA 1 Days PBTK NA NA Rat Human DTXSID9048510 TK.Half.Life NA 11.93 hours 1compartment NA NA Rat Human -DTXSID9048510 Css NA 2.045 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048510 Css NA 9.878 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048510 Css NA 1.192 mg/L PBTK NA 50% Rat Human -DTXSID9048510 Css NA 5.573 mg/L PBTK NA 95% Rat Human -DTXSID9048512 Clint NA 248.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048512 Fup NA 0.0072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048512 Vd NA 11 L/kg 1compartment NA NA Human Human -DTXSID9048512 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9048512 TK.Half.Life NA 33.31 hours 1compartment NA NA Human Human -DTXSID9048512 Css NA 0.1701 mg/L 3compartmentss NA 50% Human Human -DTXSID9048512 Css NA 0.9449 mg/L 3compartmentss NA 95% Human Human -DTXSID9048512 Css NA 0.2157 mg/L PBTK NA 50% Human Human -DTXSID9048512 Css NA 1.172 mg/L PBTK NA 95% Human Human -DTXSID9048512 Clint NA 248.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048512 Fup NA 0.0072 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048512 Vd NA 8.701 L/kg 1compartment NA NA Rat Human -DTXSID9048512 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9048512 TK.Half.Life NA 5.658 hours 1compartment NA NA Rat Human -DTXSID9048512 Css NA 0.09204 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048512 Css NA 0.3973 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048512 Css NA 0.1172 mg/L PBTK NA 50% Rat Human -DTXSID9048512 Css NA 0.5099 mg/L PBTK NA 95% Rat Human -DTXSID9048514 Clint NA 26.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048514 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048514 Vd NA 0.2266 L/kg 1compartment NA NA Human Human +DTXSID9048510 Css NA 0.4639 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048510 Css NA 2.194 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048510 Css NA 0.2809 mg/L PBTK NA 50% Rat Human +DTXSID9048510 Css NA 1.295 mg/L PBTK NA 95% Rat Human +DTXSID9048514 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048514 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048514 Vd NA 0.2301 L/kg 1compartment NA NA Human Human DTXSID9048514 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048514 TK.Half.Life NA 3.129 hours 1compartment NA NA Human Human -DTXSID9048514 Css NA 2.444 mg/L 3compartmentss NA 50% Human Human -DTXSID9048514 Css NA 24.34 mg/L 3compartmentss NA 95% Human Human -DTXSID9048514 Css NA 1.445 mg/L PBTK NA 50% Human Human -DTXSID9048514 Css NA 14.27 mg/L PBTK NA 95% Human Human -DTXSID9048514 Clint NA 26.51 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048514 Fup NA 0.0109 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048514 Vd NA 0.212 L/kg 1compartment NA NA Rat Human +DTXSID9048514 TK.Half.Life NA 2.615 hours 1compartment NA NA Human Human +DTXSID9048514 Css NA 1.928 mg/L 3compartmentss NA 50% Human Human +DTXSID9048514 Css NA 19.49 mg/L 3compartmentss NA 95% Human Human +DTXSID9048514 Css NA 1.146 mg/L PBTK NA 50% Human Human +DTXSID9048514 Css NA 11.36 mg/L PBTK NA 95% Human Human +DTXSID9048514 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048514 Fup 0.0165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048514 Vd NA 0.2182 L/kg 1compartment NA NA Rat Human DTXSID9048514 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048514 TK.Half.Life NA 1.953 hours 1compartment NA NA Rat Human -DTXSID9048514 Css NA 1.416 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048514 Css NA 11.73 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048514 Css NA 0.7792 mg/L PBTK NA 50% Rat Human -DTXSID9048514 Css NA 6.362 mg/L PBTK NA 95% Rat Human -DTXSID9048516 Clint NA 23.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048516 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048516 Vd NA 0.2216 L/kg 1compartment NA NA Human Human +DTXSID9048514 TK.Half.Life NA 1.638 hours 1compartment NA NA Rat Human +DTXSID9048514 Css NA 0.2552 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048514 Css NA 2.07 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048514 Css NA 0.1462 mg/L PBTK NA 50% Rat Human +DTXSID9048514 Css NA 1.169 mg/L PBTK NA 95% Rat Human +DTXSID9048516 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048516 Fup 0.0135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048516 Vd NA 0.2473 L/kg 1compartment NA NA Human Human DTXSID9048516 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048516 TK.Half.Life NA 3.755 hours 1compartment NA NA Human Human -DTXSID9048516 Css NA 3.101 mg/L 3compartmentss NA 50% Human Human -DTXSID9048516 Css NA 30.93 mg/L 3compartmentss NA 95% Human Human -DTXSID9048516 Css NA 1.836 mg/L PBTK NA 50% Human Human -DTXSID9048516 Css NA 17.93 mg/L PBTK NA 95% Human Human -DTXSID9048516 Clint NA 23.86 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048516 Fup NA 0.0099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048516 Vd NA 0.2145 L/kg 1compartment NA NA Rat Human +DTXSID9048516 TK.Half.Life NA 3.406 hours 1compartment NA NA Human Human +DTXSID9048516 Css NA 2.389 mg/L 3compartmentss NA 50% Human Human +DTXSID9048516 Css NA 24.66 mg/L 3compartmentss NA 95% Human Human +DTXSID9048516 Css NA 1.422 mg/L PBTK NA 50% Human Human +DTXSID9048516 Css NA 14.25 mg/L PBTK NA 95% Human Human +DTXSID9048516 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048516 Fup 0.0135 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048516 Vd NA 0.2384 L/kg 1compartment NA NA Rat Human DTXSID9048516 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048516 TK.Half.Life NA 2.434 hours 1compartment NA NA Rat Human -DTXSID9048516 Css NA 1.758 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048516 Css NA 13.82 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048516 Css NA 0.9677 mg/L PBTK NA 50% Rat Human -DTXSID9048516 Css NA 7.535 mg/L PBTK NA 95% Rat Human -DTXSID9048518 Clint NA 6.631 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048518 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048518 Vd NA 0.252 L/kg 1compartment NA NA Human Human -DTXSID9048518 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9048518 TK.Half.Life NA 9.84 hours 1compartment NA NA Human Human -DTXSID9048518 Css NA 7.068 mg/L 3compartmentss NA 50% Human Human -DTXSID9048518 Css NA 65.52 mg/L 3compartmentss NA 95% Human Human -DTXSID9048518 Css NA 4.23 mg/L PBTK NA 50% Human Human -DTXSID9048518 Css NA 37.98 mg/L PBTK NA 95% Human Human -DTXSID9048518 Clint NA 6.631 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048518 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048518 Vd NA 0.2429 L/kg 1compartment NA NA Rat Human +DTXSID9048516 TK.Half.Life NA 2.183 hours 1compartment NA NA Rat Human +DTXSID9048516 Css NA 0.3121 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048516 Css NA 2.433 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048516 Css NA 0.1795 mg/L PBTK NA 50% Rat Human +DTXSID9048516 Css NA 1.371 mg/L PBTK NA 95% Rat Human +DTXSID9048518 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048518 Fup 0.0309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048518 Vd NA 0.2751 L/kg 1compartment NA NA Human Human +DTXSID9048518 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048518 TK.Half.Life NA 1.806 hours 1compartment NA NA Human Human +DTXSID9048518 Css NA 1.036 mg/L 3compartmentss NA 50% Human Human +DTXSID9048518 Css NA 9.926 mg/L 3compartmentss NA 95% Human Human +DTXSID9048518 Css NA 0.6284 mg/L PBTK NA 50% Human Human +DTXSID9048518 Css NA 5.806 mg/L PBTK NA 95% Human Human +DTXSID9048518 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048518 Fup 0.0309 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048518 Vd NA 0.2683 L/kg 1compartment NA NA Rat Human DTXSID9048518 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048518 TK.Half.Life NA 6.07 hours 1compartment NA NA Rat Human -DTXSID9048518 Css NA 3.812 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048518 Css NA 25.71 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048518 Css NA 2.124 mg/L PBTK NA 50% Rat Human -DTXSID9048518 Css NA 14.01 mg/L PBTK NA 95% Rat Human -DTXSID9048641 Clint NA 5.527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048641 Fup NA 0.3133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048641 Vd NA 1.259 L/kg 1compartment NA NA Human Human +DTXSID9048518 TK.Half.Life NA 1.137 hours 1compartment NA NA Rat Human +DTXSID9048518 Css NA 0.1353 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048518 Css NA 1.054 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048518 Css NA 0.07898 mg/L PBTK NA 50% Rat Human +DTXSID9048518 Css NA 0.5994 mg/L PBTK NA 95% Rat Human +DTXSID9048641 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048641 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048641 Vd NA 0.7407 L/kg 1compartment NA NA Human Human DTXSID9048641 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048641 TK.Half.Life NA 3.271 hours 1compartment NA NA Human Human -DTXSID9048641 Css NA 0.224 mg/L 3compartmentss NA 50% Human Human -DTXSID9048641 Css NA 1.432 mg/L 3compartmentss NA 95% Human Human -DTXSID9048641 Css NA 0.1794 mg/L PBTK NA 50% Human Human -DTXSID9048641 Css NA 1.007 mg/L PBTK NA 95% Human Human -DTXSID9048641 Clint NA 5.527 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048641 Fup NA 0.3133 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048641 Vd NA 1.241 L/kg 1compartment NA NA Rat Human +DTXSID9048641 TK.Half.Life NA 1.558 hours 1compartment NA NA Human Human +DTXSID9048641 Css NA 0.1443 mg/L 3compartmentss NA 50% Human Human +DTXSID9048641 Css NA 1.002 mg/L 3compartmentss NA 95% Human Human +DTXSID9048641 Css NA 0.1087 mg/L PBTK NA 50% Human Human +DTXSID9048641 Css NA 0.6691 mg/L PBTK NA 95% Human Human +DTXSID9048641 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048641 Fup 0.383 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048641 Vd NA 0.6947 L/kg 1compartment NA NA Rat Human DTXSID9048641 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048641 TK.Half.Life NA 1.842 hours 1compartment NA NA Rat Human -DTXSID9048641 Css NA 0.1127 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048641 Css NA 0.5221 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048641 Css NA 0.08692 mg/L PBTK NA 50% Rat Human -DTXSID9048641 Css NA 0.341 mg/L PBTK NA 95% Rat Human -DTXSID9048643 Clint NA 19.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9048641 TK.Half.Life NA 0.8119 hours 1compartment NA NA Rat Human +DTXSID9048641 Css NA 0.006292 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048641 Css NA 0.04994 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048641 Css NA 0.004748 mg/L PBTK NA 50% Rat Human +DTXSID9048641 Css NA 0.03297 mg/L PBTK NA 95% Rat Human +DTXSID9048643 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9048643 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human -DTXSID9048643 Vd NA 0.818 L/kg 1compartment NA NA Human Human -DTXSID9048643 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048643 TK.Half.Life NA 5.585 hours 1compartment NA NA Human Human -DTXSID9048643 Css NA 1.095 mg/L 3compartmentss NA 50% Human Human -DTXSID9048643 Css NA 10.09 mg/L 3compartmentss NA 95% Human Human -DTXSID9048643 Css NA 0.6733 mg/L PBTK NA 50% Human Human -DTXSID9048643 Css NA 5.937 mg/L PBTK NA 95% Human Human -DTXSID9048643 Clint NA 19.98 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9048643 Vd NA 0.8825 L/kg 1compartment NA NA Human Human +DTXSID9048643 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9048643 TK.Half.Life NA 16.62 hours 1compartment NA NA Human Human +DTXSID9048643 Css NA 3.173 mg/L 3compartmentss NA 50% Human Human +DTXSID9048643 Css NA 25.79 mg/L 3compartmentss NA 95% Human Human +DTXSID9048643 Css NA 1.958 mg/L PBTK NA 50% Human Human +DTXSID9048643 Css NA 15.51 mg/L PBTK NA 95% Human Human +DTXSID9048643 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9048643 Fup 0.03 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human -DTXSID9048643 Vd NA 0.6516 L/kg 1compartment NA NA Rat Human +DTXSID9048643 Vd NA 0.6977 L/kg 1compartment NA NA Rat Human DTXSID9048643 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048643 TK.Half.Life NA 2.728 hours 1compartment NA NA Rat Human -DTXSID9048643 Css NA 0.6229 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048643 Css NA 4.611 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048643 Css NA 0.357 mg/L PBTK NA 50% Rat Human -DTXSID9048643 Css NA 2.539 mg/L PBTK NA 95% Rat Human -DTXSID9048645 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048645 Fup NA 0.1209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048645 Vd NA 0.337 L/kg 1compartment NA NA Human Human +DTXSID9048643 TK.Half.Life NA 7.803 hours 1compartment NA NA Rat Human +DTXSID9048643 Css NA 0.3962 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048643 Css NA 2.532 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048643 Css NA 0.2361 mg/L PBTK NA 50% Rat Human +DTXSID9048643 Css NA 1.454 mg/L PBTK NA 95% Rat Human +DTXSID9048645 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048645 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048645 Vd NA 0.3433 L/kg 1compartment NA NA Human Human DTXSID9048645 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9048645 TK.Half.Life NA 18.12 hours 1compartment NA NA Human Human -DTXSID9048645 Css NA 8.2 mg/L 3compartmentss NA 50% Human Human -DTXSID9048645 Css NA 37.62 mg/L 3compartmentss NA 95% Human Human -DTXSID9048645 Css NA 5.103 mg/L PBTK NA 50% Human Human -DTXSID9048645 Css NA 22.06 mg/L PBTK NA 95% Human Human -DTXSID9048645 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048645 Fup NA 0.1209 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048645 Vd NA 0.3144 L/kg 1compartment NA NA Rat Human +DTXSID9048645 TK.Half.Life NA 17.31 hours 1compartment NA NA Human Human +DTXSID9048645 Css NA 4.055 mg/L 3compartmentss NA 50% Human Human +DTXSID9048645 Css NA 20.5 mg/L 3compartmentss NA 95% Human Human +DTXSID9048645 Css NA 2.526 mg/L PBTK NA 50% Human Human +DTXSID9048645 Css NA 12.01 mg/L PBTK NA 95% Human Human +DTXSID9048645 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048645 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048645 Vd NA 0.3208 L/kg 1compartment NA NA Rat Human DTXSID9048645 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048645 TK.Half.Life NA 5.738 hours 1compartment NA NA Rat Human -DTXSID9048645 Css NA 2.331 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048645 Css NA 8.87 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048645 Css NA 1.356 mg/L PBTK NA 50% Rat Human -DTXSID9048645 Css NA 4.892 mg/L PBTK NA 95% Rat Human +DTXSID9048645 TK.Half.Life NA 5.492 hours 1compartment NA NA Rat Human +DTXSID9048645 Css NA 0.02214 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048645 Css NA 0.1063 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048645 Css NA 0.01303 mg/L PBTK NA 50% Rat Human +DTXSID9048645 Css NA 0.0598 mg/L PBTK NA 95% Rat Human DTXSID9048647 Clint NA 21.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9048647 Fup NA 0.8767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048647 Vd NA 0.9879 L/kg 1compartment NA NA Human Human +DTXSID9048647 Vd NA 0.64 L/kg 1compartment NA NA Human Human DTXSID9048647 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048647 TK.Half.Life NA 0.7245 hours 1compartment NA NA Human Human -DTXSID9048647 Css NA 0.02681 mg/L 3compartmentss NA 50% Human Human -DTXSID9048647 Css NA 0.2737 mg/L 3compartmentss NA 95% Human Human -DTXSID9048647 Css NA 0.02244 mg/L PBTK NA 50% Human Human -DTXSID9048647 Css NA 0.194 mg/L PBTK NA 95% Human Human +DTXSID9048647 TK.Half.Life NA 0.4365 hours 1compartment NA NA Human Human +DTXSID9048647 Css NA 0.008122 mg/L 3compartmentss NA 50% Human Human +DTXSID9048647 Css NA 0.1191 mg/L 3compartmentss NA 95% Human Human +DTXSID9048647 Css NA 0.006401 mg/L PBTK NA 50% Human Human +DTXSID9048647 Css NA 0.08175 mg/L PBTK NA 95% Human Human DTXSID9048647 Clint NA 21.43 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9048647 Fup NA 0.8767 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048647 Vd NA 1.014 L/kg 1compartment NA NA Rat Human +DTXSID9048647 Vd NA 0.6837 L/kg 1compartment NA NA Rat Human DTXSID9048647 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048647 TK.Half.Life NA 0.359 hours 1compartment NA NA Rat Human -DTXSID9048647 Css NA 0.01342 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048647 Css NA 0.1139 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048647 Css NA 0.01118 mg/L PBTK NA 50% Rat Human -DTXSID9048647 Css NA 0.07822 mg/L PBTK NA 95% Rat Human -DTXSID9048649 Clint NA 64.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048649 Fup NA 0.096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048649 Vd NA 1.757 L/kg 1compartment NA NA Human Human -DTXSID9048649 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048649 TK.Half.Life NA 2.83 hours 1compartment NA NA Human Human -DTXSID9048649 Css NA 0.1216 mg/L 3compartmentss NA 50% Human Human -DTXSID9048649 Css NA 0.9261 mg/L 3compartmentss NA 95% Human Human -DTXSID9048649 Css NA 0.08124 mg/L PBTK NA 50% Human Human -DTXSID9048649 Css NA 0.5917 mg/L PBTK NA 95% Human Human -DTXSID9048649 Clint NA 64.65 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048649 Fup NA 0.096 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048649 Vd NA 1.338 L/kg 1compartment NA NA Rat Human +DTXSID9048647 TK.Half.Life NA 0.2128 hours 1compartment NA NA Rat Human +DTXSID9048647 Css NA 0.0002885 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048647 Css NA 0.004503 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048647 Css NA 0.0002258 mg/L PBTK NA 50% Rat Human +DTXSID9048647 Css NA 0.003013 mg/L PBTK NA 95% Rat Human +DTXSID9048649 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048649 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048649 Vd NA 1.786 L/kg 1compartment NA NA Human Human +DTXSID9048649 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9048649 TK.Half.Life NA 14.37 hours 1compartment NA NA Human Human +DTXSID9048649 Css NA 1.061 mg/L 3compartmentss NA 50% Human Human +DTXSID9048649 Css NA 6.726 mg/L 3compartmentss NA 95% Human Human +DTXSID9048649 Css NA 0.716 mg/L PBTK NA 50% Human Human +DTXSID9048649 Css NA 4.301 mg/L PBTK NA 95% Human Human +DTXSID9048649 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048649 Fup 0.102 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048649 Vd NA 1.361 L/kg 1compartment NA NA Rat Human DTXSID9048649 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048649 TK.Half.Life NA 1.003 hours 1compartment NA NA Rat Human -DTXSID9048649 Css NA 0.06834 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048649 Css NA 0.424 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048649 Css NA 0.0433 mg/L PBTK NA 50% Rat Human -DTXSID9048649 Css NA 0.2539 mg/L PBTK NA 95% Rat Human -DTXSID9048691 Clint NA 1962 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048691 Fup NA 0.0467 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048691 Vd NA 1.951 L/kg 1compartment NA NA Human Human -DTXSID9048691 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048691 TK.Half.Life NA 1.773 hours 1compartment NA NA Human Human -DTXSID9048691 Css NA 0.008578 mg/L 3compartmentss NA 50% Human Human -DTXSID9048691 Css NA 0.0652 mg/L 3compartmentss NA 95% Human Human -DTXSID9048691 Css NA 0.005624 mg/L PBTK NA 50% Human Human -DTXSID9048691 Css NA 0.04073 mg/L PBTK NA 95% Human Human -DTXSID9048691 Clint NA 1962 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048691 Fup NA 0.0467 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048691 Vd NA 1.458 L/kg 1compartment NA NA Rat Human +DTXSID9048649 TK.Half.Life NA 5.016 hours 1compartment NA NA Rat Human +DTXSID9048649 Css NA 0.1308 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048649 Css NA 0.6029 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048649 Css NA 0.08639 mg/L PBTK NA 50% Rat Human +DTXSID9048649 Css NA 0.3684 mg/L PBTK NA 95% Rat Human +DTXSID9048691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048691 Fup 0.0768 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048691 Vd NA 2.603 L/kg 1compartment NA NA Human Human +DTXSID9048691 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9048691 TK.Half.Life NA 15.31 hours 1compartment NA NA Human Human +DTXSID9048691 Css NA 0.6674 mg/L 3compartmentss NA 50% Human Human +DTXSID9048691 Css NA 4.398 mg/L 3compartmentss NA 95% Human Human +DTXSID9048691 Css NA 0.4554 mg/L PBTK NA 50% Human Human +DTXSID9048691 Css NA 2.893 mg/L PBTK NA 95% Human Human +DTXSID9048691 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048691 Fup 0.0768 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048691 Vd NA 1.952 L/kg 1compartment NA NA Rat Human DTXSID9048691 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048691 TK.Half.Life NA 0.5805 hours 1compartment NA NA Rat Human -DTXSID9048691 Css NA 0.00491 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048691 Css NA 0.03028 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048691 Css NA 0.003037 mg/L PBTK NA 50% Rat Human -DTXSID9048691 Css NA 0.01811 mg/L PBTK NA 95% Rat Human -DTXSID9048693 Clint NA 10.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048693 Fup NA 0.7744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048693 Vd NA 3.565 L/kg 1compartment NA NA Human Human +DTXSID9048691 TK.Half.Life NA 3.666 hours 1compartment NA NA Rat Human +DTXSID9048691 Css NA 0.06906 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048691 Css NA 0.3714 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048691 Css NA 0.04702 mg/L PBTK NA 50% Rat Human +DTXSID9048691 Css NA 0.2398 mg/L PBTK NA 95% Rat Human +DTXSID9048693 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048693 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048693 Vd NA 3.025 L/kg 1compartment NA NA Human Human DTXSID9048693 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048693 TK.Half.Life NA 2.775 hours 1compartment NA NA Human Human -DTXSID9048693 Css NA 0.03771 mg/L 3compartmentss NA 50% Human Human -DTXSID9048693 Css NA 0.4293 mg/L 3compartmentss NA 95% Human Human -DTXSID9048693 Css NA 0.04746 mg/L PBTK NA 50% Human Human -DTXSID9048693 Css NA 0.3602 mg/L PBTK NA 95% Human Human -DTXSID9048693 Clint NA 10.53 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048693 Fup NA 0.7744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048693 Vd NA 3.625 L/kg 1compartment NA NA Rat Human +DTXSID9048693 TK.Half.Life NA 3.821 hours 1compartment NA NA Human Human +DTXSID9048693 Css NA 0.07452 mg/L 3compartmentss NA 50% Human Human +DTXSID9048693 Css NA 0.8393 mg/L 3compartmentss NA 95% Human Human +DTXSID9048693 Css NA 0.08624 mg/L PBTK NA 50% Human Human +DTXSID9048693 Css NA 0.6475 mg/L PBTK NA 95% Human Human +DTXSID9048693 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048693 Fup 0.616 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048693 Vd NA 3.066 L/kg 1compartment NA NA Rat Human DTXSID9048693 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048693 TK.Half.Life NA 1.54 hours 1compartment NA NA Rat Human -DTXSID9048693 Css NA 0.0182 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048693 Css NA 0.1843 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048693 Css NA 0.0234 mg/L PBTK NA 50% Rat Human -DTXSID9048693 Css NA 0.1442 mg/L PBTK NA 95% Rat Human -DTXSID9048695 Clint NA 35.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048695 Fup NA 0.0293 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048695 Vd NA 2.868 L/kg 1compartment NA NA Human Human -DTXSID9048695 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9048695 TK.Half.Life NA 25.56 hours 1compartment NA NA Human Human -DTXSID9048695 Css NA 1.14 mg/L 3compartmentss NA 50% Human Human -DTXSID9048695 Css NA 7.307 mg/L 3compartmentss NA 95% Human Human -DTXSID9048695 Css NA 0.7754 mg/L PBTK NA 50% Human Human -DTXSID9048695 Css NA 4.752 mg/L PBTK NA 95% Human Human -DTXSID9048695 Clint NA 35.48 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048695 Fup NA 0.0293 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048695 Vd NA 2.147 L/kg 1compartment NA NA Rat Human -DTXSID9048695 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9048695 TK.Half.Life NA 4.899 hours 1compartment NA NA Rat Human -DTXSID9048695 Css NA 0.6268 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048695 Css NA 3.472 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048695 Css NA 0.4065 mg/L PBTK NA 50% Rat Human -DTXSID9048695 Css NA 2.197 mg/L PBTK NA 95% Rat Human -DTXSID9048697 Clint NA 11.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048697 Fup NA 0.4117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048697 Vd NA 102.8 L/kg 1compartment NA NA Human Human -DTXSID9048697 Days.Css NA 462 Days PBTK NA NA Human Human -DTXSID9048697 TK.Half.Life NA 1811 hours 1compartment NA NA Human Human -DTXSID9048697 Css NA 0.1208 mg/L 3compartmentss NA 50% Human Human -DTXSID9048697 Css NA 0.9688 mg/L 3compartmentss NA 95% Human Human -DTXSID9048697 Css NA 1.516 mg/L PBTK NA 50% Human Human -DTXSID9048697 Css NA 8.705 mg/L PBTK NA 95% Human Human -DTXSID9048697 Clint NA 11.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048697 Fup NA 0.4117 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048697 Vd NA 88.91 L/kg 1compartment NA NA Rat Human -DTXSID9048697 Days.Css NA 285 Days PBTK NA NA Rat Human -DTXSID9048697 TK.Half.Life NA 271.7 hours 1compartment NA NA Rat Human -DTXSID9048697 Css NA 0.05846 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048697 Css NA 0.3727 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048697 Css NA 0.793 mg/L PBTK NA 50% Rat Human -DTXSID9048697 Css NA 3.73 mg/L PBTK NA 95% Rat Human -DTXSID9048699 Clint NA 115.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048699 Fup NA 0.0192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048699 Vd NA 2.667 L/kg 1compartment NA NA Human Human -DTXSID9048699 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048699 TK.Half.Life NA 8.965 hours 1compartment NA NA Human Human -DTXSID9048699 Css NA 0.3694 mg/L 3compartmentss NA 50% Human Human -DTXSID9048699 Css NA 2.815 mg/L 3compartmentss NA 95% Human Human -DTXSID9048699 Css NA 0.2478 mg/L PBTK NA 50% Human Human -DTXSID9048699 Css NA 1.797 mg/L PBTK NA 95% Human Human -DTXSID9048699 Clint NA 115.1 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048699 Fup NA 0.0192 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048699 Vd NA 1.992 L/kg 1compartment NA NA Rat Human -DTXSID9048699 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048699 TK.Half.Life NA 2.174 hours 1compartment NA NA Rat Human -DTXSID9048699 Css NA 0.2088 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048699 Css NA 1.265 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048699 Css NA 0.1328 mg/L PBTK NA 50% Rat Human -DTXSID9048699 Css NA 0.7703 mg/L PBTK NA 95% Rat Human -DTXSID9048720 Clint NA 34.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048720 Fup NA 0.1604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048720 Vd NA 1.739 L/kg 1compartment NA NA Human Human -DTXSID9048720 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048720 TK.Half.Life NA 2.79 hours 1compartment NA NA Human Human -DTXSID9048720 Css NA 0.1132 mg/L 3compartmentss NA 50% Human Human -DTXSID9048720 Css NA 0.8537 mg/L 3compartmentss NA 95% Human Human -DTXSID9048720 Css NA 0.08083 mg/L PBTK NA 50% Human Human -DTXSID9048720 Css NA 0.5795 mg/L PBTK NA 95% Human Human -DTXSID9048720 Clint NA 34.26 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048720 Fup NA 0.1604 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048720 Vd NA 1.399 L/kg 1compartment NA NA Rat Human +DTXSID9048693 TK.Half.Life NA 2.185 hours 1compartment NA NA Rat Human +DTXSID9048693 Css NA 0.00811 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048693 Css NA 0.07961 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048693 Css NA 0.009864 mg/L PBTK NA 50% Rat Human +DTXSID9048693 Css NA 0.05785 mg/L PBTK NA 95% Rat Human +DTXSID9048695 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048695 Fup 0.0129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048695 Vd NA 2.833 L/kg 1compartment NA NA Human Human +DTXSID9048695 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID9048695 TK.Half.Life NA 54.24 hours 1compartment NA NA Human Human +DTXSID9048695 Css NA 2.51 mg/L 3compartmentss NA 50% Human Human +DTXSID9048695 Css NA 17.41 mg/L 3compartmentss NA 95% Human Human +DTXSID9048695 Css NA 1.695 mg/L PBTK NA 50% Human Human +DTXSID9048695 Css NA 11.34 mg/L PBTK NA 95% Human Human +DTXSID9048695 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048695 Fup 0.0129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048695 Vd NA 2.117 L/kg 1compartment NA NA Rat Human +DTXSID9048695 Days.Css NA 4 Days PBTK NA NA Rat Human +DTXSID9048695 TK.Half.Life NA 10.25 hours 1compartment NA NA Rat Human +DTXSID9048695 Css NA 0.326 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048695 Css NA 1.874 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048695 Css NA 0.2174 mg/L PBTK NA 50% Rat Human +DTXSID9048695 Css NA 1.237 mg/L PBTK NA 95% Rat Human +DTXSID9048699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048699 Fup 0.0427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048699 Vd NA 3.003 L/kg 1compartment NA NA Human Human +DTXSID9048699 Days.Css NA 5 Days PBTK NA NA Human Human +DTXSID9048699 TK.Half.Life NA 45.78 hours 1compartment NA NA Human Human +DTXSID9048699 Css NA 1.848 mg/L 3compartmentss NA 50% Human Human +DTXSID9048699 Css NA 11.68 mg/L 3compartmentss NA 95% Human Human +DTXSID9048699 Css NA 1.278 mg/L PBTK NA 50% Human Human +DTXSID9048699 Css NA 7.872 mg/L PBTK NA 95% Human Human +DTXSID9048699 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048699 Fup 0.0427 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048699 Vd NA 2.25 L/kg 1compartment NA NA Rat Human +DTXSID9048699 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID9048699 TK.Half.Life NA 7.391 hours 1compartment NA NA Rat Human +DTXSID9048699 Css NA 0.2399 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048699 Css NA 1.318 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048699 Css NA 0.1633 mg/L PBTK NA 50% Rat Human +DTXSID9048699 Css NA 0.8743 mg/L PBTK NA 95% Rat Human +DTXSID9048720 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048720 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048720 Vd NA 0.9544 L/kg 1compartment NA NA Human Human +DTXSID9048720 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID9048720 TK.Half.Life NA 24.06 hours 1compartment NA NA Human Human +DTXSID9048720 Css NA 2.662 mg/L 3compartmentss NA 50% Human Human +DTXSID9048720 Css NA 10.64 mg/L 3compartmentss NA 95% Human Human +DTXSID9048720 Css NA 1.972 mg/L PBTK NA 50% Human Human +DTXSID9048720 Css NA 6.867 mg/L PBTK NA 95% Human Human +DTXSID9048720 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048720 Fup 0.267 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048720 Vd NA 0.8796 L/kg 1compartment NA NA Rat Human DTXSID9048720 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048720 TK.Half.Life NA 1.088 hours 1compartment NA NA Rat Human -DTXSID9048720 Css NA 0.06284 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048720 Css NA 0.3667 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048720 Css NA 0.0429 mg/L PBTK NA 50% Rat Human -DTXSID9048720 Css NA 0.2317 mg/L PBTK NA 95% Rat Human -DTXSID9048722 Clint NA 995.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048722 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048722 Vd NA 1.265 L/kg 1compartment NA NA Human Human +DTXSID9048720 TK.Half.Life NA 7.333 hours 1compartment NA NA Rat Human +DTXSID9048720 Css NA 0.1737 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048720 Css NA 0.5609 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048720 Css NA 0.1268 mg/L PBTK NA 50% Rat Human +DTXSID9048720 Css NA 0.3487 mg/L PBTK NA 95% Rat Human +DTXSID9048722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048722 Fup 0.0593 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048722 Vd NA 1.695 L/kg 1compartment NA NA Human Human DTXSID9048722 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048722 TK.Half.Life NA 1.29 hours 1compartment NA NA Human Human -DTXSID9048722 Css NA 0.02182 mg/L 3compartmentss NA 50% Human Human -DTXSID9048722 Css NA 0.1999 mg/L 3compartmentss NA 95% Human Human -DTXSID9048722 Css NA 0.01367 mg/L PBTK NA 50% Human Human -DTXSID9048722 Css NA 0.1196 mg/L PBTK NA 95% Human Human -DTXSID9048722 Clint NA 995.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048722 Fup NA 0.0318 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048722 Vd NA 0.9635 L/kg 1compartment NA NA Rat Human +DTXSID9048722 TK.Half.Life NA 7.212 hours 1compartment NA NA Human Human +DTXSID9048722 Css NA 0.4718 mg/L 3compartmentss NA 50% Human Human +DTXSID9048722 Css NA 3.429 mg/L 3compartmentss NA 95% Human Human +DTXSID9048722 Css NA 0.3096 mg/L PBTK NA 50% Human Human +DTXSID9048722 Css NA 2.178 mg/L PBTK NA 95% Human Human +DTXSID9048722 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048722 Fup 0.0593 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048722 Vd NA 1.3 L/kg 1compartment NA NA Rat Human DTXSID9048722 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048722 TK.Half.Life NA 0.4481 hours 1compartment NA NA Rat Human -DTXSID9048722 Css NA 0.01254 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048722 Css NA 0.1014 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048722 Css NA 0.007356 mg/L PBTK NA 50% Rat Human -DTXSID9048722 Css NA 0.05594 mg/L PBTK NA 95% Rat Human -DTXSID9048724 Clint NA 4.059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048724 Fup NA 0.021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048724 Vd NA 0.2702 L/kg 1compartment NA NA Human Human -DTXSID9048724 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9048724 TK.Half.Life NA 10.73 hours 1compartment NA NA Human Human -DTXSID9048724 Css NA 7.176 mg/L 3compartmentss NA 50% Human Human -DTXSID9048724 Css NA 58.94 mg/L 3compartmentss NA 95% Human Human -DTXSID9048724 Css NA 4.313 mg/L PBTK NA 50% Human Human -DTXSID9048724 Css NA 34.85 mg/L PBTK NA 95% Human Human -DTXSID9048724 Clint NA 4.059 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048724 Fup NA 0.021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048724 Vd NA 0.2482 L/kg 1compartment NA NA Rat Human +DTXSID9048722 TK.Half.Life NA 2.736 hours 1compartment NA NA Rat Human +DTXSID9048722 Css NA 0.02312 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048722 Css NA 0.1984 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048722 Css NA 0.01465 mg/L PBTK NA 50% Rat Human +DTXSID9048722 Css NA 0.1195 mg/L PBTK NA 95% Rat Human +DTXSID9048724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048724 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048724 Vd NA 0.2603 L/kg 1compartment NA NA Human Human +DTXSID9048724 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048724 TK.Half.Life NA 2.586 hours 1compartment NA NA Human Human +DTXSID9048724 Css NA 1.643 mg/L 3compartmentss NA 50% Human Human +DTXSID9048724 Css NA 16.9 mg/L 3compartmentss NA 95% Human Human +DTXSID9048724 Css NA 0.9811 mg/L PBTK NA 50% Human Human +DTXSID9048724 Css NA 9.871 mg/L PBTK NA 95% Human Human +DTXSID9048724 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048724 Fup 0.0189 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048724 Vd NA 0.2397 L/kg 1compartment NA NA Rat Human DTXSID9048724 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048724 TK.Half.Life NA 6.038 hours 1compartment NA NA Rat Human -DTXSID9048724 Css NA 3.67 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048724 Css NA 22.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048724 Css NA 2.055 mg/L PBTK NA 50% Rat Human -DTXSID9048724 Css NA 12.21 mg/L PBTK NA 95% Rat Human -DTXSID9048726 Clint NA 193.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048726 Fup NA 0.4276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048726 Vd NA 2.131 L/kg 1compartment NA NA Human Human +DTXSID9048724 TK.Half.Life NA 1.566 hours 1compartment NA NA Rat Human +DTXSID9048724 Css NA 0.2184 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048724 Css NA 1.79 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048724 Css NA 0.126 mg/L PBTK NA 50% Rat Human +DTXSID9048724 Css NA 1.007 mg/L PBTK NA 95% Rat Human +DTXSID9048726 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048726 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048726 Vd NA 1.234 L/kg 1compartment NA NA Human Human DTXSID9048726 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048726 TK.Half.Life NA 1.174 hours 1compartment NA NA Human Human -DTXSID9048726 Css NA 0.003959 mg/L 3compartmentss NA 50% Human Human -DTXSID9048726 Css NA 0.03841 mg/L 3compartmentss NA 95% Human Human -DTXSID9048726 Css NA 0.004056 mg/L PBTK NA 50% Human Human -DTXSID9048726 Css NA 0.03136 mg/L PBTK NA 95% Human Human -DTXSID9048726 Clint NA 193.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048726 Fup NA 0.4276 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048726 Vd NA 2.109 L/kg 1compartment NA NA Rat Human +DTXSID9048726 TK.Half.Life NA 1.853 hours 1compartment NA NA Human Human +DTXSID9048726 Css NA 0.1036 mg/L 3compartmentss NA 50% Human Human +DTXSID9048726 Css NA 1.014 mg/L 3compartmentss NA 95% Human Human +DTXSID9048726 Css NA 0.09047 mg/L PBTK NA 50% Human Human +DTXSID9048726 Css NA 0.7054 mg/L PBTK NA 95% Human Human +DTXSID9048726 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048726 Fup 0.566 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048726 Vd NA 1.226 L/kg 1compartment NA NA Rat Human DTXSID9048726 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048726 TK.Half.Life NA 0.5275 hours 1compartment NA NA Rat Human -DTXSID9048726 Css NA 0.002071 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048726 Css NA 0.01672 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048726 Css NA 0.002124 mg/L PBTK NA 50% Rat Human -DTXSID9048726 Css NA 0.01361 mg/L PBTK NA 95% Rat Human -DTXSID9048728 Clint NA 5.954 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048728 Fup NA 0.8107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048728 Vd NA 3.131 L/kg 1compartment NA NA Human Human -DTXSID9048728 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9048728 TK.Half.Life NA 39.18 hours 1compartment NA NA Human Human -DTXSID9048728 Css NA 1.396 mg/L 3compartmentss NA 50% Human Human -DTXSID9048728 Css NA 7.476 mg/L 3compartmentss NA 95% Human Human -DTXSID9048728 Css NA 1.025 mg/L PBTK NA 50% Human Human -DTXSID9048728 Css NA 5.25 mg/L PBTK NA 95% Human Human -DTXSID9048728 Clint NA 5.954 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048728 Fup NA 0.8107 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048728 Vd NA 2.373 L/kg 1compartment NA NA Rat Human -DTXSID9048728 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9048728 TK.Half.Life NA 5.608 hours 1compartment NA NA Rat Human -DTXSID9048728 Css NA 0.739 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048728 Css NA 3.012 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048728 Css NA 0.5207 mg/L PBTK NA 50% Rat Human -DTXSID9048728 Css NA 2.03 mg/L PBTK NA 95% Rat Human -DTXSID9048772 Clint NA 14.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048772 Fup NA 0.1675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048772 Vd NA 2.077 L/kg 1compartment NA NA Human Human -DTXSID9048772 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048772 TK.Half.Life NA 6.589 hours 1compartment NA NA Human Human -DTXSID9048772 Css NA 0.319 mg/L 3compartmentss NA 50% Human Human -DTXSID9048772 Css NA 1.928 mg/L 3compartmentss NA 95% Human Human -DTXSID9048772 Css NA 0.2264 mg/L PBTK NA 50% Human Human -DTXSID9048772 Css NA 1.299 mg/L PBTK NA 95% Human Human -DTXSID9048772 Clint NA 14.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048772 Fup NA 0.1675 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048772 Vd NA 1.591 L/kg 1compartment NA NA Rat Human +DTXSID9048726 TK.Half.Life NA 1.013 hours 1compartment NA NA Rat Human +DTXSID9048726 Css NA 0.01198 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048726 Css NA 0.0988 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048726 Css NA 0.01065 mg/L PBTK NA 50% Rat Human +DTXSID9048726 Css NA 0.06479 mg/L PBTK NA 95% Rat Human +DTXSID9048728 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048728 Fup 0.0635 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048728 Vd NA 2.425 L/kg 1compartment NA NA Human Human +DTXSID9048728 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9048728 TK.Half.Life NA 13.85 hours 1compartment NA NA Human Human +DTXSID9048728 Css NA 0.6919 mg/L 3compartmentss NA 50% Human Human +DTXSID9048728 Css NA 4.668 mg/L 3compartmentss NA 95% Human Human +DTXSID9048728 Css NA 0.468 mg/L PBTK NA 50% Human Human +DTXSID9048728 Css NA 3.024 mg/L PBTK NA 95% Human Human +DTXSID9048728 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048728 Fup 0.0635 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048728 Vd NA 1.822 L/kg 1compartment NA NA Rat Human +DTXSID9048728 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9048728 TK.Half.Life NA 3.725 hours 1compartment NA NA Rat Human +DTXSID9048728 Css NA 0.08934 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048728 Css NA 0.486 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048728 Css NA 0.05928 mg/L PBTK NA 50% Rat Human +DTXSID9048728 Css NA 0.3148 mg/L PBTK NA 95% Rat Human +DTXSID9048772 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048772 Fup 0.0302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048772 Vd NA 0.9691 L/kg 1compartment NA NA Human Human +DTXSID9048772 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9048772 TK.Half.Life NA 18.36 hours 1compartment NA NA Human Human +DTXSID9048772 Css NA 3.192 mg/L 3compartmentss NA 50% Human Human +DTXSID9048772 Css NA 25.79 mg/L 3compartmentss NA 95% Human Human +DTXSID9048772 Css NA 1.965 mg/L PBTK NA 50% Human Human +DTXSID9048772 Css NA 14.95 mg/L PBTK NA 95% Human Human +DTXSID9048772 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048772 Fup 0.0302 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048772 Vd NA 0.7301 L/kg 1compartment NA NA Rat Human DTXSID9048772 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048772 TK.Half.Life NA 2.153 hours 1compartment NA NA Rat Human -DTXSID9048772 Css NA 0.1704 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048772 Css NA 0.8256 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048772 Css NA 0.1158 mg/L PBTK NA 50% Rat Human -DTXSID9048772 Css NA 0.515 mg/L PBTK NA 95% Rat Human -DTXSID9048774 Clint NA 67.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048774 Fup NA 0.0953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048774 Vd NA 0.3821 L/kg 1compartment NA NA Human Human +DTXSID9048772 TK.Half.Life NA 7.95 hours 1compartment NA NA Rat Human +DTXSID9048772 Css NA 0.3963 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048772 Css NA 2.48 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048772 Css NA 0.2349 mg/L PBTK NA 50% Rat Human +DTXSID9048772 Css NA 1.406 mg/L PBTK NA 95% Rat Human +DTXSID9048774 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048774 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048774 Vd NA 0.5167 L/kg 1compartment NA NA Human Human DTXSID9048774 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048774 TK.Half.Life NA 0.5696 hours 1compartment NA NA Human Human -DTXSID9048774 Css NA 0.1038 mg/L 3compartmentss NA 50% Human Human -DTXSID9048774 Css NA 0.8577 mg/L 3compartmentss NA 95% Human Human -DTXSID9048774 Css NA 0.06401 mg/L PBTK NA 50% Human Human -DTXSID9048774 Css NA 0.5128 mg/L PBTK NA 95% Human Human -DTXSID9048774 Clint NA 67.17 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048774 Fup NA 0.0953 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048774 Vd NA 0.3471 L/kg 1compartment NA NA Rat Human +DTXSID9048774 TK.Half.Life NA 2.035 hours 1compartment NA NA Human Human +DTXSID9048774 Css NA 0.4071 mg/L 3compartmentss NA 50% Human Human +DTXSID9048774 Css NA 2.36 mg/L 3compartmentss NA 95% Human Human +DTXSID9048774 Css NA 0.269 mg/L PBTK NA 50% Human Human +DTXSID9048774 Css NA 1.472 mg/L PBTK NA 95% Human Human +DTXSID9048774 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048774 Fup 0.176 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048774 Vd NA 0.4682 L/kg 1compartment NA NA Rat Human DTXSID9048774 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048774 TK.Half.Life NA 0.2764 hours 1compartment NA NA Rat Human -DTXSID9048774 Css NA 0.05947 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048774 Css NA 0.4082 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048774 Css NA 0.03435 mg/L PBTK NA 50% Rat Human -DTXSID9048774 Css NA 0.2295 mg/L PBTK NA 95% Rat Human -DTXSID9048776 Clint NA 76.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048776 Fup NA 0.0368 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048776 Vd NA 2.964 L/kg 1compartment NA NA Human Human +DTXSID9048774 TK.Half.Life NA 1.082 hours 1compartment NA NA Rat Human +DTXSID9048774 Css NA 0.04919 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048774 Css NA 0.209 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048774 Css NA 0.03189 mg/L PBTK NA 50% Rat Human +DTXSID9048774 Css NA 0.1262 mg/L PBTK NA 95% Rat Human +DTXSID9048776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048776 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048776 Vd NA 0.4044 L/kg 1compartment NA NA Human Human DTXSID9048776 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048776 TK.Half.Life NA 14.07 hours 1compartment NA NA Human Human -DTXSID9048776 Css NA 0.525 mg/L 3compartmentss NA 50% Human Human -DTXSID9048776 Css NA 3.323 mg/L 3compartmentss NA 95% Human Human -DTXSID9048776 Css NA 0.3619 mg/L PBTK NA 50% Human Human -DTXSID9048776 Css NA 2.212 mg/L PBTK NA 95% Human Human -DTXSID9048776 Clint NA 76.74 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048776 Fup NA 0.0368 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048776 Vd NA 2.222 L/kg 1compartment NA NA Rat Human +DTXSID9048776 TK.Half.Life NA 0.8325 hours 1compartment NA NA Human Human +DTXSID9048776 Css NA 0.1882 mg/L 3compartmentss NA 50% Human Human +DTXSID9048776 Css NA 1.513 mg/L 3compartmentss NA 95% Human Human +DTXSID9048776 Css NA 0.1199 mg/L PBTK NA 50% Human Human +DTXSID9048776 Css NA 0.9243 mg/L PBTK NA 95% Human Human +DTXSID9048776 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048776 Fup 0.142 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048776 Vd NA 0.3948 L/kg 1compartment NA NA Rat Human DTXSID9048776 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048776 TK.Half.Life NA 2.679 hours 1compartment NA NA Rat Human -DTXSID9048776 Css NA 0.2951 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048776 Css NA 1.544 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048776 Css NA 0.1929 mg/L PBTK NA 50% Rat Human -DTXSID9048776 Css NA 0.9914 mg/L PBTK NA 95% Rat Human -DTXSID9048778 Clint NA 5.841 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048778 Fup NA 0.0106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048778 Vd NA 3.087 L/kg 1compartment NA NA Human Human -DTXSID9048778 Days.Css NA 70 Days PBTK NA NA Human Human -DTXSID9048778 TK.Half.Life NA 317.5 hours 1compartment NA NA Human Human -DTXSID9048778 Css NA 13.02 mg/L 3compartmentss NA 50% Human Human -DTXSID9048778 Css NA 76.49 mg/L 3compartmentss NA 95% Human Human -DTXSID9048778 Css NA 8.997 mg/L PBTK NA 50% Human Human -DTXSID9048778 Css NA 51.16 mg/L PBTK NA 95% Human Human -DTXSID9048778 Clint NA 5.841 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048778 Fup NA 0.0106 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048778 Vd NA 2.312 L/kg 1compartment NA NA Rat Human -DTXSID9048778 Days.Css NA 38 Days PBTK NA NA Rat Human -DTXSID9048778 TK.Half.Life NA 43.29 hours 1compartment NA NA Rat Human -DTXSID9048778 Css NA 7.276 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048778 Css NA 34.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048778 Css NA 4.797 mg/L PBTK NA 50% Rat Human -DTXSID9048778 Css NA 21.64 mg/L PBTK NA 95% Rat Human -DTXSID9048801 Clint NA 10.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048801 Fup NA 0.0205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048801 Vd NA 0.3442 L/kg 1compartment NA NA Human Human +DTXSID9048776 TK.Half.Life NA 0.4658 hours 1compartment NA NA Rat Human +DTXSID9048776 Css NA 0.02434 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048776 Css NA 0.1537 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048776 Css NA 0.01506 mg/L PBTK NA 50% Rat Human +DTXSID9048776 Css NA 0.09088 mg/L PBTK NA 95% Rat Human +DTXSID9048778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048778 Fup 0.00946 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048778 Vd NA 3.023 L/kg 1compartment NA NA Human Human +DTXSID9048778 Days.Css NA 12 Days PBTK NA NA Human Human +DTXSID9048778 TK.Half.Life NA 78.04 hours 1compartment NA NA Human Human +DTXSID9048778 Css NA 3.202 mg/L 3compartmentss NA 50% Human Human +DTXSID9048778 Css NA 20.75 mg/L 3compartmentss NA 95% Human Human +DTXSID9048778 Css NA 2.189 mg/L PBTK NA 50% Human Human +DTXSID9048778 Css NA 14.03 mg/L PBTK NA 95% Human Human +DTXSID9048778 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048778 Fup 0.00946 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048778 Vd NA 2.263 L/kg 1compartment NA NA Rat Human +DTXSID9048778 Days.Css NA 7 Days PBTK NA NA Rat Human +DTXSID9048778 TK.Half.Life NA 11.94 hours 1compartment NA NA Rat Human +DTXSID9048778 Css NA 0.4152 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048778 Css NA 2.401 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048778 Css NA 0.2813 mg/L PBTK NA 50% Rat Human +DTXSID9048778 Css NA 1.578 mg/L PBTK NA 95% Rat Human +DTXSID9048801 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048801 Fup 0.0204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048801 Vd NA 0.3457 L/kg 1compartment NA NA Human Human DTXSID9048801 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048801 TK.Half.Life NA 6.027 hours 1compartment NA NA Human Human -DTXSID9048801 Css NA 3.102 mg/L 3compartmentss NA 50% Human Human -DTXSID9048801 Css NA 29.07 mg/L 3compartmentss NA 95% Human Human -DTXSID9048801 Css NA 1.882 mg/L PBTK NA 50% Human Human -DTXSID9048801 Css NA 16.9 mg/L PBTK NA 95% Human Human -DTXSID9048801 Clint NA 10.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048801 Fup NA 0.0205 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048801 Vd NA 0.2968 L/kg 1compartment NA NA Rat Human +DTXSID9048801 TK.Half.Life NA 3.138 hours 1compartment NA NA Human Human +DTXSID9048801 Css NA 1.5 mg/L 3compartmentss NA 50% Human Human +DTXSID9048801 Css NA 14.63 mg/L 3compartmentss NA 95% Human Human +DTXSID9048801 Css NA 0.9072 mg/L PBTK NA 50% Human Human +DTXSID9048801 Css NA 8.501 mg/L PBTK NA 95% Human Human +DTXSID9048801 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048801 Fup 0.0204 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048801 Vd NA 0.2979 L/kg 1compartment NA NA Rat Human DTXSID9048801 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048801 TK.Half.Life NA 3.362 hours 1compartment NA NA Rat Human -DTXSID9048801 Css NA 1.712 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048801 Css NA 12.02 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048801 Css NA 0.9614 mg/L PBTK NA 50% Rat Human -DTXSID9048801 Css NA 6.556 mg/L PBTK NA 95% Rat Human -DTXSID9048803 Clint NA 4.971 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048803 Fup NA 0.4526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048803 Vd NA 2.144 L/kg 1compartment NA NA Human Human +DTXSID9048801 TK.Half.Life NA 1.762 hours 1compartment NA NA Rat Human +DTXSID9048801 Css NA 0.1955 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048801 Css NA 1.58 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048801 Css NA 0.1137 mg/L PBTK NA 50% Rat Human +DTXSID9048801 Css NA 0.8922 mg/L PBTK NA 95% Rat Human +DTXSID9048803 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048803 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048803 Vd NA 2.298 L/kg 1compartment NA NA Human Human DTXSID9048803 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048803 TK.Half.Life NA 6.608 hours 1compartment NA NA Human Human -DTXSID9048803 Css NA 0.2825 mg/L 3compartmentss NA 50% Human Human -DTXSID9048803 Css NA 1.609 mg/L 3compartmentss NA 95% Human Human -DTXSID9048803 Css NA 0.227 mg/L PBTK NA 50% Human Human -DTXSID9048803 Css NA 1.164 mg/L PBTK NA 95% Human Human -DTXSID9048803 Clint NA 4.971 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048803 Fup NA 0.4526 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048803 Vd NA 1.695 L/kg 1compartment NA NA Rat Human +DTXSID9048803 TK.Half.Life NA 10.11 hours 1compartment NA NA Human Human +DTXSID9048803 Css NA 0.4326 mg/L 3compartmentss NA 50% Human Human +DTXSID9048803 Css NA 2.369 mg/L 3compartmentss NA 95% Human Human +DTXSID9048803 Css NA 0.3228 mg/L PBTK NA 50% Human Human +DTXSID9048803 Css NA 1.644 mg/L PBTK NA 95% Human Human +DTXSID9048803 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048803 Fup 0.285 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048803 Vd NA 1.771 L/kg 1compartment NA NA Rat Human DTXSID9048803 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048803 TK.Half.Life NA 2.128 hours 1compartment NA NA Rat Human -DTXSID9048803 Css NA 0.1406 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048803 Css NA 0.5833 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048803 Css NA 0.1093 mg/L PBTK NA 50% Rat Human -DTXSID9048803 Css NA 0.3976 mg/L PBTK NA 95% Rat Human -DTXSID9048805 Clint NA 3.988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048805 Fup NA 0.0888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048805 Vd NA 0.3665 L/kg 1compartment NA NA Human Human +DTXSID9048803 TK.Half.Life NA 2.937 hours 1compartment NA NA Rat Human +DTXSID9048803 Css NA 0.05084 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048803 Css NA 0.201 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048803 Css NA 0.03797 mg/L PBTK NA 50% Rat Human +DTXSID9048803 Css NA 0.138 mg/L PBTK NA 95% Rat Human +DTXSID9048805 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048805 Fup 0.0907 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048805 Vd NA 0.3699 L/kg 1compartment NA NA Human Human DTXSID9048805 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048805 TK.Half.Life NA 3.729 hours 1compartment NA NA Human Human -DTXSID9048805 Css NA 1.584 mg/L 3compartmentss NA 50% Human Human -DTXSID9048805 Css NA 10.02 mg/L 3compartmentss NA 95% Human Human -DTXSID9048805 Css NA 0.9918 mg/L PBTK NA 50% Human Human -DTXSID9048805 Css NA 5.983 mg/L PBTK NA 95% Human Human -DTXSID9048805 Clint NA 3.988 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048805 Fup NA 0.0888 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048805 Vd NA 0.3413 L/kg 1compartment NA NA Rat Human +DTXSID9048805 TK.Half.Life NA 1.018 hours 1compartment NA NA Human Human +DTXSID9048805 Css NA 0.3127 mg/L 3compartmentss NA 50% Human Human +DTXSID9048805 Css NA 2.472 mg/L 3compartmentss NA 95% Human Human +DTXSID9048805 Css NA 0.1964 mg/L PBTK NA 50% Human Human +DTXSID9048805 Css NA 1.5 mg/L PBTK NA 95% Human Human +DTXSID9048805 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048805 Fup 0.0907 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048805 Vd NA 0.3445 L/kg 1compartment NA NA Rat Human DTXSID9048805 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048805 TK.Half.Life NA 2.072 hours 1compartment NA NA Rat Human -DTXSID9048805 Css NA 0.8046 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048805 Css NA 3.937 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048805 Css NA 0.4739 mg/L PBTK NA 50% Rat Human -DTXSID9048805 Css NA 2.216 mg/L PBTK NA 95% Rat Human -DTXSID9048807 Clint NA 3.278 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048807 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048807 Vd NA 0.2076 L/kg 1compartment NA NA Human Human -DTXSID9048807 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9048807 TK.Half.Life NA 14.64 hours 1compartment NA NA Human Human -DTXSID9048807 Css NA 12.87 mg/L 3compartmentss NA 50% Human Human -DTXSID9048807 Css NA 101.5 mg/L 3compartmentss NA 95% Human Human -DTXSID9048807 Css NA 7.592 mg/L PBTK NA 50% Human Human -DTXSID9048807 Css NA 59.76 mg/L PBTK NA 95% Human Human -DTXSID9048807 Clint NA 3.278 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048807 Fup NA 0.0142 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048807 Vd NA 0.1961 L/kg 1compartment NA NA Rat Human +DTXSID9048805 TK.Half.Life NA 0.5677 hours 1compartment NA NA Rat Human +DTXSID9048805 Css NA 0.04131 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048805 Css NA 0.2577 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048805 Css NA 0.02521 mg/L PBTK NA 50% Rat Human +DTXSID9048805 Css NA 0.1498 mg/L PBTK NA 95% Rat Human +DTXSID9048807 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048807 Fup 0.0424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048807 Vd NA 0.3489 L/kg 1compartment NA NA Human Human +DTXSID9048807 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048807 TK.Half.Life NA 1.711 hours 1compartment NA NA Human Human +DTXSID9048807 Css NA 0.6525 mg/L 3compartmentss NA 50% Human Human +DTXSID9048807 Css NA 5.887 mg/L 3compartmentss NA 95% Human Human +DTXSID9048807 Css NA 0.3971 mg/L PBTK NA 50% Human Human +DTXSID9048807 Css NA 3.477 mg/L PBTK NA 95% Human Human +DTXSID9048807 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048807 Fup 0.0424 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048807 Vd NA 0.3082 L/kg 1compartment NA NA Rat Human DTXSID9048807 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048807 TK.Half.Life NA 8.308 hours 1compartment NA NA Rat Human -DTXSID9048807 Css NA 6.472 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048807 Css NA 41.05 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048807 Css NA 3.547 mg/L PBTK NA 50% Rat Human -DTXSID9048807 Css NA 22.22 mg/L PBTK NA 95% Rat Human -DTXSID9048809 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048809 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048809 Vd NA 31.86 L/kg 1compartment NA NA Human Human -DTXSID9048809 Days.Css NA 5901 Days PBTK NA NA Human Human -DTXSID9048809 TK.Half.Life NA 1523000 hours 1compartment NA NA Human Human -DTXSID9048809 Css NA 1102 mg/L 3compartmentss NA 50% Human Human -DTXSID9048809 Css NA 2751 mg/L 3compartmentss NA 95% Human Human -DTXSID9048809 Css NA 3716 mg/L PBTK NA 50% Human Human -DTXSID9048809 Css NA 7937 mg/L PBTK NA 95% Human Human -DTXSID9048809 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048809 Fup NA 0.009 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048809 Vd NA 26.38 L/kg 1compartment NA NA Rat Human -DTXSID9048809 Days.Css NA 13780 Days PBTK NA NA Rat Human -DTXSID9048809 TK.Half.Life NA 107300 hours 1compartment NA NA Rat Human -DTXSID9048809 Css NA 273.6 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048809 Css NA 465 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048809 Css NA 992 mg/L PBTK NA 50% Rat Human -DTXSID9048809 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID9048851 Clint NA 52.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048851 Fup NA 0.6191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048851 Vd NA 1.08 L/kg 1compartment NA NA Human Human +DTXSID9048807 TK.Half.Life NA 0.9537 hours 1compartment NA NA Rat Human +DTXSID9048807 Css NA 0.03252 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048807 Css NA 0.3205 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048807 Css NA 0.019 mg/L PBTK NA 50% Rat Human +DTXSID9048807 Css NA 0.1832 mg/L PBTK NA 95% Rat Human +DTXSID9048851 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048851 Fup 0.547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048851 Vd NA 0.9566 L/kg 1compartment NA NA Human Human DTXSID9048851 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048851 TK.Half.Life NA 0.7767 hours 1compartment NA NA Human Human -DTXSID9048851 Css NA 0.01414 mg/L 3compartmentss NA 50% Human Human -DTXSID9048851 Css NA 0.1635 mg/L 3compartmentss NA 95% Human Human -DTXSID9048851 Css NA 0.01192 mg/L PBTK NA 50% Human Human -DTXSID9048851 Css NA 0.1113 mg/L PBTK NA 95% Human Human -DTXSID9048851 Clint NA 52.56 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048851 Fup NA 0.6191 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048851 Vd NA 1 L/kg 1compartment NA NA Rat Human +DTXSID9048851 TK.Half.Life NA 1.533 hours 1compartment NA NA Human Human +DTXSID9048851 Css NA 0.117 mg/L 3compartmentss NA 50% Human Human +DTXSID9048851 Css NA 1.005 mg/L 3compartmentss NA 95% Human Human +DTXSID9048851 Css NA 0.09526 mg/L PBTK NA 50% Human Human +DTXSID9048851 Css NA 0.6845 mg/L PBTK NA 95% Human Human +DTXSID9048851 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048851 Fup 0.547 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048851 Vd NA 0.8939 L/kg 1compartment NA NA Rat Human DTXSID9048851 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048851 TK.Half.Life NA 0.3331 hours 1compartment NA NA Rat Human -DTXSID9048851 Css NA 0.007544 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048851 Css NA 0.07617 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048851 Css NA 0.006197 mg/L PBTK NA 50% Rat Human -DTXSID9048851 Css NA 0.04897 mg/L PBTK NA 95% Rat Human -DTXSID9048853 Clint NA 14.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048853 Fup NA 0.1981 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048853 Vd NA 1.525 L/kg 1compartment NA NA Human Human +DTXSID9048851 TK.Half.Life NA 0.7698 hours 1compartment NA NA Rat Human +DTXSID9048851 Css NA 0.01314 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048851 Css NA 0.09676 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048851 Css NA 0.01091 mg/L PBTK NA 50% Rat Human +DTXSID9048851 Css NA 0.06167 mg/L PBTK NA 95% Rat Human +DTXSID9048853 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048853 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048853 Vd NA 1.689 L/kg 1compartment NA NA Human Human DTXSID9048853 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048853 TK.Half.Life NA 2.633 hours 1compartment NA NA Human Human -DTXSID9048853 Css NA 0.1137 mg/L 3compartmentss NA 50% Human Human -DTXSID9048853 Css NA 0.8129 mg/L 3compartmentss NA 95% Human Human -DTXSID9048853 Css NA 0.09873 mg/L PBTK NA 50% Human Human -DTXSID9048853 Css NA 0.6188 mg/L PBTK NA 95% Human Human -DTXSID9048853 Clint NA 14.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048853 Fup NA 0.1981 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048853 Vd NA 1.489 L/kg 1compartment NA NA Rat Human +DTXSID9048853 TK.Half.Life NA 4.289 hours 1compartment NA NA Human Human +DTXSID9048853 Css NA 0.1852 mg/L 3compartmentss NA 50% Human Human +DTXSID9048853 Css NA 1.263 mg/L 3compartmentss NA 95% Human Human +DTXSID9048853 Css NA 0.1689 mg/L PBTK NA 50% Human Human +DTXSID9048853 Css NA 0.973 mg/L PBTK NA 95% Human Human +DTXSID9048853 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048853 Fup 0.238 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048853 Vd NA 1.652 L/kg 1compartment NA NA Rat Human DTXSID9048853 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048853 TK.Half.Life NA 1.501 hours 1compartment NA NA Rat Human -DTXSID9048853 Css NA 0.06058 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048853 Css NA 0.3395 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048853 Css NA 0.0514 mg/L PBTK NA 50% Rat Human -DTXSID9048853 Css NA 0.2492 mg/L PBTK NA 95% Rat Human -DTXSID9048855 Clint NA 3.025 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048855 Fup NA 0.9099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048855 Vd NA 1.844 L/kg 1compartment NA NA Human Human -DTXSID9048855 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048855 TK.Half.Life NA 2.806 hours 1compartment NA NA Human Human -DTXSID9048855 Css NA 0.1373 mg/L 3compartmentss NA 50% Human Human -DTXSID9048855 Css NA 1.064 mg/L 3compartmentss NA 95% Human Human -DTXSID9048855 Css NA 0.1336 mg/L PBTK NA 50% Human Human -DTXSID9048855 Css NA 0.782 mg/L PBTK NA 95% Human Human -DTXSID9048855 Clint NA 3.025 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048855 Fup NA 0.9099 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048855 Vd NA 1.871 L/kg 1compartment NA NA Rat Human +DTXSID9048853 TK.Half.Life NA 2.496 hours 1compartment NA NA Rat Human +DTXSID9048853 Css NA 0.022 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048853 Css NA 0.1168 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048853 Css NA 0.02038 mg/L PBTK NA 50% Rat Human +DTXSID9048853 Css NA 0.08671 mg/L PBTK NA 95% Rat Human +DTXSID9048855 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048855 Fup 0.804 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048855 Vd NA 1.696 L/kg 1compartment NA NA Human Human +DTXSID9048855 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9048855 TK.Half.Life NA 13.69 hours 1compartment NA NA Human Human +DTXSID9048855 Css NA 0.834 mg/L 3compartmentss NA 50% Human Human +DTXSID9048855 Css NA 5.436 mg/L 3compartmentss NA 95% Human Human +DTXSID9048855 Css NA 0.8023 mg/L PBTK NA 50% Human Human +DTXSID9048855 Css NA 3.666 mg/L PBTK NA 95% Human Human +DTXSID9048855 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048855 Fup 0.804 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048855 Vd NA 1.718 L/kg 1compartment NA NA Rat Human DTXSID9048855 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048855 TK.Half.Life NA 1.52 hours 1compartment NA NA Rat Human -DTXSID9048855 Css NA 0.05918 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048855 Css NA 0.4008 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048855 Css NA 0.05774 mg/L PBTK NA 50% Rat Human -DTXSID9048855 Css NA 0.2666 mg/L PBTK NA 95% Rat Human -DTXSID9048857 Clint NA 12.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048857 Fup NA 0.1833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048857 Vd NA 2.811 L/kg 1compartment NA NA Human Human -DTXSID9048857 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9048857 TK.Half.Life NA 17.43 hours 1compartment NA NA Human Human -DTXSID9048857 Css NA 0.666 mg/L 3compartmentss NA 50% Human Human -DTXSID9048857 Css NA 3.903 mg/L 3compartmentss NA 95% Human Human -DTXSID9048857 Css NA 0.4786 mg/L PBTK NA 50% Human Human -DTXSID9048857 Css NA 2.623 mg/L PBTK NA 95% Human Human -DTXSID9048857 Clint NA 12.59 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048857 Fup NA 0.1833 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048857 Vd NA 2.134 L/kg 1compartment NA NA Rat Human +DTXSID9048855 TK.Half.Life NA 4.715 hours 1compartment NA NA Rat Human +DTXSID9048855 Css NA 0.04814 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048855 Css NA 0.3131 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048855 Css NA 0.04709 mg/L PBTK NA 50% Rat Human +DTXSID9048855 Css NA 0.2054 mg/L PBTK NA 95% Rat Human +DTXSID9048857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048857 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048857 Vd NA 2.551 L/kg 1compartment NA NA Human Human +DTXSID9048857 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048857 TK.Half.Life NA 9.11 hours 1compartment NA NA Human Human +DTXSID9048857 Css NA 0.3682 mg/L 3compartmentss NA 50% Human Human +DTXSID9048857 Css NA 2.424 mg/L 3compartmentss NA 95% Human Human +DTXSID9048857 Css NA 0.2579 mg/L PBTK NA 50% Human Human +DTXSID9048857 Css NA 1.62 mg/L PBTK NA 95% Human Human +DTXSID9048857 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048857 Fup 0.139 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048857 Vd NA 1.939 L/kg 1compartment NA NA Rat Human DTXSID9048857 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048857 TK.Half.Life NA 3.719 hours 1compartment NA NA Rat Human -DTXSID9048857 Css NA 0.3628 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048857 Css NA 1.582 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048857 Css NA 0.2495 mg/L PBTK NA 50% Rat Human -DTXSID9048857 Css NA 1.068 mg/L PBTK NA 95% Rat Human -DTXSID9048859 Clint NA 5.741 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048859 Fup NA 0.1272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048859 Vd NA 2.763 L/kg 1compartment NA NA Human Human -DTXSID9048859 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9048859 TK.Half.Life NA 21.41 hours 1compartment NA NA Human Human -DTXSID9048859 Css NA 0.9059 mg/L 3compartmentss NA 50% Human Human -DTXSID9048859 Css NA 5.391 mg/L 3compartmentss NA 95% Human Human -DTXSID9048859 Css NA 0.6931 mg/L PBTK NA 50% Human Human -DTXSID9048859 Css NA 3.801 mg/L PBTK NA 95% Human Human -DTXSID9048859 Clint NA 5.741 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048859 Fup NA 0.1272 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048859 Vd NA 2.29 L/kg 1compartment NA NA Rat Human -DTXSID9048859 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9048859 TK.Half.Life NA 6.925 hours 1compartment NA NA Rat Human -DTXSID9048859 Css NA 0.4743 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048859 Css NA 2.113 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048859 Css NA 0.3498 mg/L PBTK NA 50% Rat Human -DTXSID9048859 Css NA 1.391 mg/L PBTK NA 95% Rat Human -DTXSID9048930 Clint NA 14.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048930 Fup NA 0.0693 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048930 Vd NA 3.069 L/kg 1compartment NA NA Human Human -DTXSID9048930 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048930 TK.Half.Life NA 9.826 hours 1compartment NA NA Human Human -DTXSID9048930 Css NA 0.2825 mg/L 3compartmentss NA 50% Human Human -DTXSID9048930 Css NA 1.924 mg/L 3compartmentss NA 95% Human Human -DTXSID9048930 Css NA 0.2308 mg/L PBTK NA 50% Human Human -DTXSID9048930 Css NA 1.506 mg/L PBTK NA 95% Human Human -DTXSID9048930 Clint NA 14.71 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048930 Fup NA 0.0693 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048930 Vd NA 2.65 L/kg 1compartment NA NA Rat Human +DTXSID9048857 TK.Half.Life NA 2.419 hours 1compartment NA NA Rat Human +DTXSID9048857 Css NA 0.0465 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048857 Css NA 0.2446 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048857 Css NA 0.0324 mg/L PBTK NA 50% Rat Human +DTXSID9048857 Css NA 0.1623 mg/L PBTK NA 95% Rat Human +DTXSID9048859 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048859 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048859 Vd NA 3.38 L/kg 1compartment NA NA Human Human +DTXSID9048859 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048859 TK.Half.Life NA 6.684 hours 1compartment NA NA Human Human +DTXSID9048859 Css NA 0.1352 mg/L 3compartmentss NA 50% Human Human +DTXSID9048859 Css NA 0.9009 mg/L 3compartmentss NA 95% Human Human +DTXSID9048859 Css NA 0.1159 mg/L PBTK NA 50% Human Human +DTXSID9048859 Css NA 0.717 mg/L PBTK NA 95% Human Human +DTXSID9048859 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048859 Fup 0.289 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048859 Vd NA 2.843 L/kg 1compartment NA NA Rat Human +DTXSID9048859 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9048859 TK.Half.Life NA 1.991 hours 1compartment NA NA Rat Human +DTXSID9048859 Css NA 0.01658 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048859 Css NA 0.0898 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048859 Css NA 0.01446 mg/L PBTK NA 50% Rat Human +DTXSID9048859 Css NA 0.07256 mg/L PBTK NA 95% Rat Human +DTXSID9048930 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048930 Fup 0.0529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048930 Vd NA 2.595 L/kg 1compartment NA NA Human Human +DTXSID9048930 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9048930 TK.Half.Life NA 17.18 hours 1compartment NA NA Human Human +DTXSID9048930 Css NA 0.8134 mg/L 3compartmentss NA 50% Human Human +DTXSID9048930 Css NA 5.591 mg/L 3compartmentss NA 95% Human Human +DTXSID9048930 Css NA 0.5586 mg/L PBTK NA 50% Human Human +DTXSID9048930 Css NA 3.671 mg/L PBTK NA 95% Human Human +DTXSID9048930 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048930 Fup 0.0529 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048930 Vd NA 1.991 L/kg 1compartment NA NA Rat Human DTXSID9048930 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048930 TK.Half.Life NA 3.612 hours 1compartment NA NA Rat Human -DTXSID9048930 Css NA 0.1554 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048930 Css NA 0.8506 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048930 Css NA 0.1226 mg/L PBTK NA 50% Rat Human -DTXSID9048930 Css NA 0.6162 mg/L PBTK NA 95% Rat Human -DTXSID9048932 Clint NA 21.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048932 Fup NA 0.0715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048932 Vd NA 3.102 L/kg 1compartment NA NA Human Human +DTXSID9048930 TK.Half.Life NA 4.581 hours 1compartment NA NA Rat Human +DTXSID9048930 Css NA 0.1054 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048930 Css NA 0.575 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048930 Css NA 0.07142 mg/L PBTK NA 50% Rat Human +DTXSID9048930 Css NA 0.3723 mg/L PBTK NA 95% Rat Human +DTXSID9048932 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048932 Fup 0.0428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048932 Vd NA 2.912 L/kg 1compartment NA NA Human Human DTXSID9048932 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9048932 TK.Half.Life NA 18.98 hours 1compartment NA NA Human Human -DTXSID9048932 Css NA 0.6692 mg/L 3compartmentss NA 50% Human Human -DTXSID9048932 Css NA 4.375 mg/L 3compartmentss NA 95% Human Human -DTXSID9048932 Css NA 0.4842 mg/L PBTK NA 50% Human Human -DTXSID9048932 Css NA 3.034 mg/L PBTK NA 95% Human Human -DTXSID9048932 Clint NA 21.13 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048932 Fup NA 0.0715 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048932 Vd NA 2.402 L/kg 1compartment NA NA Rat Human -DTXSID9048932 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9048932 TK.Half.Life NA 3.813 hours 1compartment NA NA Rat Human -DTXSID9048932 Css NA 0.3732 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048932 Css NA 1.899 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048932 Css NA 0.2578 mg/L PBTK NA 50% Rat Human -DTXSID9048932 Css NA 1.254 mg/L PBTK NA 95% Rat Human -DTXSID9048934 Clint NA 14.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048934 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048934 Vd NA 2.689 L/kg 1compartment NA NA Human Human +DTXSID9048932 TK.Half.Life NA 18.37 hours 1compartment NA NA Human Human +DTXSID9048932 Css NA 0.7246 mg/L 3compartmentss NA 50% Human Human +DTXSID9048932 Css NA 5.104 mg/L 3compartmentss NA 95% Human Human +DTXSID9048932 Css NA 0.5135 mg/L PBTK NA 50% Human Human +DTXSID9048932 Css NA 3.391 mg/L PBTK NA 95% Human Human +DTXSID9048932 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048932 Fup 0.0428 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048932 Vd NA 2.253 L/kg 1compartment NA NA Rat Human +DTXSID9048932 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9048932 TK.Half.Life NA 4.239 hours 1compartment NA NA Rat Human +DTXSID9048932 Css NA 0.09402 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048932 Css NA 0.5589 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048932 Css NA 0.0656 mg/L PBTK NA 50% Rat Human +DTXSID9048932 Css NA 0.3772 mg/L PBTK NA 95% Rat Human +DTXSID9048934 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048934 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048934 Vd NA 3.136 L/kg 1compartment NA NA Human Human DTXSID9048934 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048934 TK.Half.Life NA 7.335 hours 1compartment NA NA Human Human -DTXSID9048934 Css NA 0.2664 mg/L 3compartmentss NA 50% Human Human -DTXSID9048934 Css NA 2.181 mg/L 3compartmentss NA 95% Human Human -DTXSID9048934 Css NA 0.2204 mg/L PBTK NA 50% Human Human -DTXSID9048934 Css NA 1.561 mg/L PBTK NA 95% Human Human -DTXSID9048934 Clint NA 14.73 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048934 Fup NA 0.1042 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048934 Vd NA 2.471 L/kg 1compartment NA NA Rat Human +DTXSID9048934 TK.Half.Life NA 6.436 hours 1compartment NA NA Human Human +DTXSID9048934 Css NA 0.164 mg/L 3compartmentss NA 50% Human Human +DTXSID9048934 Css NA 1.353 mg/L 3compartmentss NA 95% Human Human +DTXSID9048934 Css NA 0.1386 mg/L PBTK NA 50% Human Human +DTXSID9048934 Css NA 1.016 mg/L PBTK NA 95% Human Human +DTXSID9048934 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048934 Fup 0.113 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048934 Vd NA 2.801 L/kg 1compartment NA NA Rat Human DTXSID9048934 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048934 TK.Half.Life NA 3.529 hours 1compartment NA NA Rat Human -DTXSID9048934 Css NA 0.1442 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048934 Css NA 0.9051 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048934 Css NA 0.1144 mg/L PBTK NA 50% Rat Human -DTXSID9048934 Css NA 0.6126 mg/L PBTK NA 95% Rat Human -DTXSID9048936 Clint NA 15.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048936 Fup NA 0.0852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048936 Vd NA 2.955 L/kg 1compartment NA NA Human Human +DTXSID9048934 TK.Half.Life NA 2.634 hours 1compartment NA NA Rat Human +DTXSID9048934 Css NA 0.02082 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048934 Css NA 0.1329 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048934 Css NA 0.01775 mg/L PBTK NA 50% Rat Human +DTXSID9048934 Css NA 0.09945 mg/L PBTK NA 95% Rat Human +DTXSID9048936 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048936 Fup 0.0878 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048936 Vd NA 2.202 L/kg 1compartment NA NA Human Human DTXSID9048936 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048936 TK.Half.Life NA 8.374 hours 1compartment NA NA Human Human -DTXSID9048936 Css NA 0.2777 mg/L 3compartmentss NA 50% Human Human -DTXSID9048936 Css NA 2.198 mg/L 3compartmentss NA 95% Human Human -DTXSID9048936 Css NA 0.2276 mg/L PBTK NA 50% Human Human -DTXSID9048936 Css NA 1.603 mg/L PBTK NA 95% Human Human -DTXSID9048936 Clint NA 15.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048936 Fup NA 0.0852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048936 Vd NA 2.639 L/kg 1compartment NA NA Rat Human +DTXSID9048936 TK.Half.Life NA 8.782 hours 1compartment NA NA Human Human +DTXSID9048936 Css NA 0.4542 mg/L 3compartmentss NA 50% Human Human +DTXSID9048936 Css NA 3.096 mg/L 3compartmentss NA 95% Human Human +DTXSID9048936 Css NA 0.3076 mg/L PBTK NA 50% Human Human +DTXSID9048936 Css NA 2.013 mg/L PBTK NA 95% Human Human +DTXSID9048936 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048936 Fup 0.0878 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048936 Vd NA 1.66 L/kg 1compartment NA NA Rat Human DTXSID9048936 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048936 TK.Half.Life NA 3.569 hours 1compartment NA NA Rat Human -DTXSID9048936 Css NA 0.153 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048936 Css NA 0.9658 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048936 Css NA 0.1201 mg/L PBTK NA 50% Rat Human -DTXSID9048936 Css NA 0.6683 mg/L PBTK NA 95% Rat Human -DTXSID9048938 Clint NA 16.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048938 Fup NA 0.1061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048938 Vd NA 2.656 L/kg 1compartment NA NA Human Human -DTXSID9048938 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9048938 TK.Half.Life NA 16.61 hours 1compartment NA NA Human Human -DTXSID9048938 Css NA 0.7547 mg/L 3compartmentss NA 50% Human Human -DTXSID9048938 Css NA 4.647 mg/L 3compartmentss NA 95% Human Human -DTXSID9048938 Css NA 0.5198 mg/L PBTK NA 50% Human Human -DTXSID9048938 Css NA 3.072 mg/L PBTK NA 95% Human Human -DTXSID9048938 Clint NA 16.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048938 Fup NA 0.1061 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048938 Vd NA 2.001 L/kg 1compartment NA NA Rat Human +DTXSID9048936 TK.Half.Life NA 2.671 hours 1compartment NA NA Rat Human +DTXSID9048936 Css NA 0.05844 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048936 Css NA 0.3292 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048936 Css NA 0.03877 mg/L PBTK NA 50% Rat Human +DTXSID9048936 Css NA 0.209 mg/L PBTK NA 95% Rat Human +DTXSID9048938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048938 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048938 Vd NA 1.951 L/kg 1compartment NA NA Human Human +DTXSID9048938 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048938 TK.Half.Life NA 5.924 hours 1compartment NA NA Human Human +DTXSID9048938 Css NA 0.3212 mg/L 3compartmentss NA 50% Human Human +DTXSID9048938 Css NA 2.294 mg/L 3compartmentss NA 95% Human Human +DTXSID9048938 Css NA 0.2182 mg/L PBTK NA 50% Human Human +DTXSID9048938 Css NA 1.476 mg/L PBTK NA 95% Human Human +DTXSID9048938 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048938 Fup 0.11 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048938 Vd NA 1.481 L/kg 1compartment NA NA Rat Human DTXSID9048938 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048938 TK.Half.Life NA 3.866 hours 1compartment NA NA Rat Human -DTXSID9048938 Css NA 0.4081 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048938 Css NA 2.041 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048938 Css NA 0.2704 mg/L PBTK NA 50% Rat Human -DTXSID9048938 Css NA 1.316 mg/L PBTK NA 95% Rat Human -DTXSID9048980 Clint NA 0.8427 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048980 Fup NA 0.0588 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048980 Vd NA 0.2641 L/kg 1compartment NA NA Human Human -DTXSID9048980 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9048980 TK.Half.Life NA 12.22 hours 1compartment NA NA Human Human -DTXSID9048980 Css NA 7.652 mg/L 3compartmentss NA 50% Human Human -DTXSID9048980 Css NA 39.14 mg/L 3compartmentss NA 95% Human Human -DTXSID9048980 Css NA 4.674 mg/L PBTK NA 50% Human Human -DTXSID9048980 Css NA 22.81 mg/L PBTK NA 95% Human Human -DTXSID9048980 Clint NA 0.8427 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048980 Fup NA 0.0588 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048980 Vd NA 0.2587 L/kg 1compartment NA NA Rat Human +DTXSID9048938 TK.Half.Life NA 2.007 hours 1compartment NA NA Rat Human +DTXSID9048938 Css NA 0.04134 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048938 Css NA 0.2332 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048938 Css NA 0.02769 mg/L PBTK NA 50% Rat Human +DTXSID9048938 Css NA 0.1482 mg/L PBTK NA 95% Rat Human +DTXSID9048980 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048980 Fup 0.0801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048980 Vd NA 0.3012 L/kg 1compartment NA NA Human Human +DTXSID9048980 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9048980 TK.Half.Life NA 0.9165 hours 1compartment NA NA Human Human +DTXSID9048980 Css NA 0.3214 mg/L 3compartmentss NA 50% Human Human +DTXSID9048980 Css NA 2.629 mg/L 3compartmentss NA 95% Human Human +DTXSID9048980 Css NA 0.1986 mg/L PBTK NA 50% Human Human +DTXSID9048980 Css NA 1.582 mg/L PBTK NA 95% Human Human +DTXSID9048980 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048980 Fup 0.0801 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048980 Vd NA 0.295 L/kg 1compartment NA NA Rat Human DTXSID9048980 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048980 TK.Half.Life NA 5.8 hours 1compartment NA NA Rat Human -DTXSID9048980 Css NA 3.122 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048980 Css NA 13.01 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048980 Css NA 1.775 mg/L PBTK NA 50% Rat Human -DTXSID9048980 Css NA 7.123 mg/L PBTK NA 95% Rat Human -DTXSID9048982 Clint NA 827.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048982 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048982 Vd NA 0.7931 L/kg 1compartment NA NA Human Human -DTXSID9048982 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048982 TK.Half.Life NA 0.8686 hours 1compartment NA NA Human Human -DTXSID9048982 Css NA 0.02993 mg/L 3compartmentss NA 50% Human Human -DTXSID9048982 Css NA 0.328 mg/L 3compartmentss NA 95% Human Human -DTXSID9048982 Css NA 0.01818 mg/L PBTK NA 50% Human Human -DTXSID9048982 Css NA 0.1904 mg/L PBTK NA 95% Human Human -DTXSID9048982 Clint NA 827.5 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048982 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048982 Vd NA 0.6092 L/kg 1compartment NA NA Rat Human -DTXSID9048982 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048982 TK.Half.Life NA 0.3135 hours 1compartment NA NA Rat Human -DTXSID9048982 Css NA 0.01747 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048982 Css NA 0.1482 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048982 Css NA 0.009991 mg/L PBTK NA 50% Rat Human -DTXSID9048982 Css NA 0.08292 mg/L PBTK NA 95% Rat Human -DTXSID9048984 Clint NA 67.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048984 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048984 Vd NA 0.172 L/kg 1compartment NA NA Human Human +DTXSID9048980 TK.Half.Life NA 0.5449 hours 1compartment NA NA Rat Human +DTXSID9048980 Css NA 0.01586 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048980 Css NA 0.1362 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048980 Css NA 0.009512 mg/L PBTK NA 50% Rat Human +DTXSID9048980 Css NA 0.07804 mg/L PBTK NA 95% Rat Human +DTXSID9048982 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048982 Fup 0.0579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048982 Vd NA 2.978 L/kg 1compartment NA NA Human Human +DTXSID9048982 Days.Css NA 4 Days PBTK NA NA Human Human +DTXSID9048982 TK.Half.Life NA 35.95 hours 1compartment NA NA Human Human +DTXSID9048982 Css NA 1.426 mg/L 3compartmentss NA 50% Human Human +DTXSID9048982 Css NA 9.022 mg/L 3compartmentss NA 95% Human Human +DTXSID9048982 Css NA 0.9866 mg/L PBTK NA 50% Human Human +DTXSID9048982 Css NA 5.954 mg/L PBTK NA 95% Human Human +DTXSID9048982 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048982 Fup 0.0579 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048982 Vd NA 2.236 L/kg 1compartment NA NA Rat Human +DTXSID9048982 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID9048982 TK.Half.Life NA 6.129 hours 1compartment NA NA Rat Human +DTXSID9048982 Css NA 0.1853 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048982 Css NA 1.041 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048982 Css NA 0.1268 mg/L PBTK NA 50% Rat Human +DTXSID9048982 Css NA 0.6925 mg/L PBTK NA 95% Rat Human +DTXSID9048984 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048984 Fup 0.0636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9048984 Vd NA 0.2575 L/kg 1compartment NA NA Human Human DTXSID9048984 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048984 TK.Half.Life NA 4.854 hours 1compartment NA NA Human Human -DTXSID9048984 Css NA 5.384 mg/L 3compartmentss NA 50% Human Human -DTXSID9048984 Css NA 45.77 mg/L 3compartmentss NA 95% Human Human -DTXSID9048984 Css NA 3.127 mg/L PBTK NA 50% Human Human -DTXSID9048984 Css NA 26.84 mg/L PBTK NA 95% Human Human -DTXSID9048984 Clint NA 67.47 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048984 Fup NA 0.0021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048984 Vd NA 0.1688 L/kg 1compartment NA NA Rat Human +DTXSID9048984 TK.Half.Life NA 0.9253 hours 1compartment NA NA Human Human +DTXSID9048984 Css NA 0.2526 mg/L 3compartmentss NA 50% Human Human +DTXSID9048984 Css NA 2.148 mg/L 3compartmentss NA 95% Human Human +DTXSID9048984 Css NA 0.1522 mg/L PBTK NA 50% Human Human +DTXSID9048984 Css NA 1.265 mg/L PBTK NA 95% Human Human +DTXSID9048984 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048984 Fup 0.0636 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9048984 Vd NA 0.2568 L/kg 1compartment NA NA Rat Human DTXSID9048984 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048984 TK.Half.Life NA 3.27 hours 1compartment NA NA Rat Human -DTXSID9048984 Css NA 3.12 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048984 Css NA 19.98 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048984 Css NA 1.691 mg/L PBTK NA 50% Rat Human -DTXSID9048984 Css NA 10.82 mg/L PBTK NA 95% Rat Human -DTXSID9048986 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048986 Fup NA 0.8536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048986 Vd NA 0.992 L/kg 1compartment NA NA Human Human -DTXSID9048986 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9048986 TK.Half.Life NA 7.519 hours 1compartment NA NA Human Human -DTXSID9048986 Css NA 0.8649 mg/L 3compartmentss NA 50% Human Human -DTXSID9048986 Css NA 5.484 mg/L 3compartmentss NA 95% Human Human -DTXSID9048986 Css NA 0.7891 mg/L PBTK NA 50% Human Human -DTXSID9048986 Css NA 3.684 mg/L PBTK NA 95% Human Human -DTXSID9048986 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048986 Fup NA 0.8536 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048986 Vd NA 1.009 L/kg 1compartment NA NA Rat Human -DTXSID9048986 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048986 TK.Half.Life NA 2.606 hours 1compartment NA NA Rat Human -DTXSID9048986 Css NA 0.2165 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048986 Css NA 1.44 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048986 Css NA 0.1948 mg/L PBTK NA 50% Rat Human -DTXSID9048986 Css NA 0.8907 mg/L PBTK NA 95% Rat Human -DTXSID9048988 Clint NA 0.5463 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048988 Fup NA 0.0831 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9048988 Vd NA 3.619 L/kg 1compartment NA NA Human Human -DTXSID9048988 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9048988 TK.Half.Life NA 14.09 hours 1compartment NA NA Human Human -DTXSID9048988 Css NA 0.3238 mg/L 3compartmentss NA 50% Human Human -DTXSID9048988 Css NA 2.83 mg/L 3compartmentss NA 95% Human Human -DTXSID9048988 Css NA 0.3602 mg/L PBTK NA 50% Human Human -DTXSID9048988 Css NA 2.469 mg/L PBTK NA 95% Human Human -DTXSID9048988 Clint NA 0.5463 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048988 Fup NA 0.0831 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9048988 Vd NA 3.357 L/kg 1compartment NA NA Rat Human -DTXSID9048988 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9048988 TK.Half.Life NA 6.608 hours 1compartment NA NA Rat Human -DTXSID9048988 Css NA 0.1717 mg/L 3compartmentss NA 50% Rat Human -DTXSID9048988 Css NA 1.123 mg/L 3compartmentss NA 95% Rat Human -DTXSID9048988 Css NA 0.1894 mg/L PBTK NA 50% Rat Human -DTXSID9048988 Css NA 0.9652 mg/L PBTK NA 95% Rat Human -DTXSID9049031 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049031 Fup NA 0.0056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049031 Vd NA 1655 L/kg 1compartment NA NA Human Human -DTXSID9049031 Days.Css NA 8526 Days PBTK NA NA Human Human -DTXSID9049031 TK.Half.Life NA 77020000 hours 1compartment NA NA Human Human -DTXSID9049031 Css NA 13.26 mg/L 3compartmentss NA 50% Human Human -DTXSID9049031 Css NA 35.79 mg/L 3compartmentss NA 95% Human Human -DTXSID9049031 Css NA 3606 mg/L PBTK NA 50% Human Human -DTXSID9049031 Css NA 7772 mg/L PBTK NA 95% Human Human -DTXSID9049031 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049031 Fup NA 0.0056 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049031 Vd NA 1529 L/kg 1compartment NA NA Rat Human -DTXSID9049031 Days.Css NA 8526 Days PBTK NA NA Rat Human -DTXSID9049031 TK.Half.Life NA 6189000 hours 1compartment NA NA Rat Human -DTXSID9049031 Css NA 3.183 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049031 Css NA 6.022 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049031 Css NA 963.2 mg/L PBTK NA 50% Rat Human -DTXSID9049031 Css NA 1325 mg/L PBTK NA 95% Rat Human -DTXSID9049033 Clint NA 7.887 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049033 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049033 Vd NA 1.978 L/kg 1compartment NA NA Human Human -DTXSID9049033 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID9049033 TK.Half.Life NA 51.42 hours 1compartment NA NA Human Human -DTXSID9049033 Css NA 4.13 mg/L 3compartmentss NA 50% Human Human -DTXSID9049033 Css NA 30.14 mg/L 3compartmentss NA 95% Human Human -DTXSID9049033 Css NA 2.655 mg/L PBTK NA 50% Human Human -DTXSID9049033 Css NA 18.71 mg/L PBTK NA 95% Human Human -DTXSID9049033 Clint NA 7.887 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049033 Fup NA 0.0197 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049033 Vd NA 1.47 L/kg 1compartment NA NA Rat Human -DTXSID9049033 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9049033 TK.Half.Life NA 16.28 hours 1compartment NA NA Rat Human -DTXSID9049033 Css NA 2.28 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049033 Css NA 12.74 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049033 Css NA 1.378 mg/L PBTK NA 50% Rat Human -DTXSID9049033 Css NA 7.367 mg/L PBTK NA 95% Rat Human -DTXSID9049035 Clint NA 54.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049035 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049035 Vd NA 0.223 L/kg 1compartment NA NA Human Human +DTXSID9048984 TK.Half.Life NA 0.5691 hours 1compartment NA NA Rat Human +DTXSID9048984 Css NA 0.00274 mg/L 3compartmentss NA 50% Rat Human +DTXSID9048984 Css NA 0.02071 mg/L 3compartmentss NA 95% Rat Human +DTXSID9048984 Css NA 0.001554 mg/L PBTK NA 50% Rat Human +DTXSID9048984 Css NA 0.01163 mg/L PBTK NA 95% Rat Human +DTXSID9049033 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049033 Fup 0.0205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049033 Vd NA 1.767 L/kg 1compartment NA NA Human Human +DTXSID9049033 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID9049033 TK.Half.Life NA 16.76 hours 1compartment NA NA Human Human +DTXSID9049033 Css NA 1.444 mg/L 3compartmentss NA 50% Human Human +DTXSID9049033 Css NA 12.09 mg/L 3compartmentss NA 95% Human Human +DTXSID9049033 Css NA 0.9178 mg/L PBTK NA 50% Human Human +DTXSID9049033 Css NA 7.307 mg/L PBTK NA 95% Human Human +DTXSID9049033 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049033 Fup 0.0205 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049033 Vd NA 1.312 L/kg 1compartment NA NA Rat Human +DTXSID9049033 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9049033 TK.Half.Life NA 5.899 hours 1compartment NA NA Rat Human +DTXSID9049033 Css NA 0.185 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049033 Css NA 1.311 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049033 Css NA 0.1146 mg/L PBTK NA 50% Rat Human +DTXSID9049033 Css NA 0.7826 mg/L PBTK NA 95% Rat Human +DTXSID9049035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049035 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049035 Vd NA 0.3056 L/kg 1compartment NA NA Human Human DTXSID9049035 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049035 TK.Half.Life NA 3.517 hours 1compartment NA NA Human Human -DTXSID9049035 Css NA 2.881 mg/L 3compartmentss NA 50% Human Human -DTXSID9049035 Css NA 27.53 mg/L 3compartmentss NA 95% Human Human -DTXSID9049035 Css NA 1.698 mg/L PBTK NA 50% Human Human -DTXSID9049035 Css NA 15.75 mg/L PBTK NA 95% Human Human -DTXSID9049035 Clint NA 54.96 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049035 Fup NA 0.0045 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049035 Vd NA 0.2048 L/kg 1compartment NA NA Rat Human +DTXSID9049035 TK.Half.Life NA 2.159 hours 1compartment NA NA Human Human +DTXSID9049035 Css NA 1.136 mg/L 3compartmentss NA 50% Human Human +DTXSID9049035 Css NA 11.16 mg/L 3compartmentss NA 95% Human Human +DTXSID9049035 Css NA 0.6901 mg/L PBTK NA 50% Human Human +DTXSID9049035 Css NA 6.555 mg/L PBTK NA 95% Human Human +DTXSID9049035 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049035 Fup 0.0278 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049035 Vd NA 0.2862 L/kg 1compartment NA NA Rat Human DTXSID9049035 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049035 TK.Half.Life NA 2.189 hours 1compartment NA NA Rat Human -DTXSID9049035 Css NA 1.629 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049035 Css NA 13.63 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049035 Css NA 0.8901 mg/L PBTK NA 50% Rat Human -DTXSID9049035 Css NA 7.408 mg/L PBTK NA 95% Rat Human -DTXSID9049037 Clint NA 42.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049037 Fup NA 0.0212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049037 Vd NA 3.114 L/kg 1compartment NA NA Human Human -DTXSID9049037 Days.Css NA 5 Days PBTK NA NA Human Human -DTXSID9049037 TK.Half.Life NA 42.5 hours 1compartment NA NA Human Human -DTXSID9049037 Css NA 1.619 mg/L 3compartmentss NA 50% Human Human -DTXSID9049037 Css NA 10.46 mg/L 3compartmentss NA 95% Human Human -DTXSID9049037 Css NA 1.124 mg/L PBTK NA 50% Human Human -DTXSID9049037 Css NA 6.913 mg/L PBTK NA 95% Human Human -DTXSID9049037 Clint NA 42.38 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049037 Fup NA 0.0212 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049037 Vd NA 2.339 L/kg 1compartment NA NA Rat Human -DTXSID9049037 Days.Css NA 3 Days PBTK NA NA Rat Human -DTXSID9049037 TK.Half.Life NA 6.2 hours 1compartment NA NA Rat Human -DTXSID9049037 Css NA 0.9119 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049037 Css NA 4.605 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049037 Css NA 0.6062 mg/L PBTK NA 50% Rat Human -DTXSID9049037 Css NA 2.931 mg/L PBTK NA 95% Rat Human -DTXSID9049039 Clint NA 3.846 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049039 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049039 Vd NA 0.8474 L/kg 1compartment NA NA Human Human +DTXSID9049035 TK.Half.Life NA 1.31 hours 1compartment NA NA Rat Human +DTXSID9049035 Css NA 0.1468 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049035 Css NA 1.151 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049035 Css NA 0.08632 mg/L PBTK NA 50% Rat Human +DTXSID9049035 Css NA 0.6558 mg/L PBTK NA 95% Rat Human +DTXSID9049037 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049037 Fup 0.0944 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049037 Vd NA 0.5082 L/kg 1compartment NA NA Human Human +DTXSID9049037 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9049037 TK.Half.Life NA 1.369 hours 1compartment NA NA Human Human +DTXSID9049037 Css NA 0.2968 mg/L 3compartmentss NA 50% Human Human +DTXSID9049037 Css NA 2.51 mg/L 3compartmentss NA 95% Human Human +DTXSID9049037 Css NA 0.1871 mg/L PBTK NA 50% Human Human +DTXSID9049037 Css NA 1.531 mg/L PBTK NA 95% Human Human +DTXSID9049037 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049037 Fup 0.0944 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049037 Vd NA 0.4997 L/kg 1compartment NA NA Rat Human +DTXSID9049037 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9049037 TK.Half.Life NA 0.8051 hours 1compartment NA NA Rat Human +DTXSID9049037 Css NA 0.0398 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049037 Css NA 0.2449 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049037 Css NA 0.02437 mg/L PBTK NA 50% Rat Human +DTXSID9049037 Css NA 0.1447 mg/L PBTK NA 95% Rat Human +DTXSID9049039 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049039 Fup 0.792 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049039 Vd NA 0.6765 L/kg 1compartment NA NA Human Human DTXSID9049039 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049039 TK.Half.Life NA 1.095 hours 1compartment NA NA Human Human -DTXSID9049039 Css NA 0.1162 mg/L 3compartmentss NA 50% Human Human -DTXSID9049039 Css NA 1.053 mg/L 3compartmentss NA 95% Human Human -DTXSID9049039 Css NA 0.09833 mg/L PBTK NA 50% Human Human -DTXSID9049039 Css NA 0.7218 mg/L PBTK NA 95% Human Human -DTXSID9049039 Clint NA 3.846 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049039 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049039 Vd NA 0.8755 L/kg 1compartment NA NA Rat Human +DTXSID9049039 TK.Half.Life NA 5.527 hours 1compartment NA NA Human Human +DTXSID9049039 Css NA 0.9816 mg/L 3compartmentss NA 50% Human Human +DTXSID9049039 Css NA 6.061 mg/L 3compartmentss NA 95% Human Human +DTXSID9049039 Css NA 0.7952 mg/L PBTK NA 50% Human Human +DTXSID9049039 Css NA 3.899 mg/L PBTK NA 95% Human Human +DTXSID9049039 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049039 Fup 0.792 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049039 Vd NA 0.7089 L/kg 1compartment NA NA Rat Human DTXSID9049039 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049039 TK.Half.Life NA 0.5919 hours 1compartment NA NA Rat Human -DTXSID9049039 Css NA 0.05204 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049039 Css NA 0.3755 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049039 Css NA 0.04376 mg/L PBTK NA 50% Rat Human -DTXSID9049039 Css NA 0.2326 mg/L PBTK NA 95% Rat Human -DTXSID9049083 Clint NA 2.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049083 Fup NA 0.8408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049083 Vd NA 1.18 L/kg 1compartment NA NA Human Human +DTXSID9049039 TK.Half.Life NA 1.974 hours 1compartment NA NA Rat Human +DTXSID9049039 Css NA 0.05796 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049039 Css NA 0.3398 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049039 Css NA 0.04716 mg/L PBTK NA 50% Rat Human +DTXSID9049039 Css NA 0.2094 mg/L PBTK NA 95% Rat Human +DTXSID9049083 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049083 Fup 0.301 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049083 Vd NA 1.841 L/kg 1compartment NA NA Human Human DTXSID9049083 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049083 TK.Half.Life NA 2.256 hours 1compartment NA NA Human Human -DTXSID9049083 Css NA 0.1823 mg/L 3compartmentss NA 50% Human Human -DTXSID9049083 Css NA 1.364 mg/L 3compartmentss NA 95% Human Human -DTXSID9049083 Css NA 0.1613 mg/L PBTK NA 50% Human Human -DTXSID9049083 Css NA 0.9489 mg/L PBTK NA 95% Human Human -DTXSID9049083 Clint NA 2.499 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049083 Fup NA 0.8408 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049083 Vd NA 1.118 L/kg 1compartment NA NA Rat Human +DTXSID9049083 TK.Half.Life NA 2.726 hours 1compartment NA NA Human Human +DTXSID9049083 Css NA 0.07386 mg/L 3compartmentss NA 50% Human Human +DTXSID9049083 Css NA 0.5403 mg/L 3compartmentss NA 95% Human Human +DTXSID9049083 Css NA 0.05636 mg/L PBTK NA 50% Human Human +DTXSID9049083 Css NA 0.3854 mg/L PBTK NA 95% Human Human +DTXSID9049083 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049083 Fup 0.301 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049083 Vd NA 1.458 L/kg 1compartment NA NA Rat Human DTXSID9049083 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049083 TK.Half.Life NA 1.097 hours 1compartment NA NA Rat Human -DTXSID9049083 Css NA 0.07895 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049083 Css NA 0.5189 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049083 Css NA 0.06945 mg/L PBTK NA 50% Rat Human -DTXSID9049083 Css NA 0.3249 mg/L PBTK NA 95% Rat Human -DTXSID9049243 Clint NA 23.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049243 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049243 Vd NA 3.069 L/kg 1compartment NA NA Human Human +DTXSID9049083 TK.Half.Life NA 0.9956 hours 1compartment NA NA Rat Human +DTXSID9049083 Css NA 0.002613 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049083 Css NA 0.02117 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049083 Css NA 0.001951 mg/L PBTK NA 50% Rat Human +DTXSID9049083 Css NA 0.01458 mg/L PBTK NA 95% Rat Human +DTXSID9049243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049243 Fup 0.00777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049243 Vd NA 2.561 L/kg 1compartment NA NA Human Human DTXSID9049243 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID9049243 TK.Half.Life NA 56.58 hours 1compartment NA NA Human Human -DTXSID9049243 Css NA 2.252 mg/L 3compartmentss NA 50% Human Human -DTXSID9049243 Css NA 14.42 mg/L 3compartmentss NA 95% Human Human -DTXSID9049243 Css NA 1.553 mg/L PBTK NA 50% Human Human -DTXSID9049243 Css NA 9.844 mg/L PBTK NA 95% Human Human -DTXSID9049243 Clint NA 23.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049243 Fup NA 0.0388 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049243 Vd NA 2.3 L/kg 1compartment NA NA Rat Human +DTXSID9049243 TK.Half.Life NA 51.57 hours 1compartment NA NA Human Human +DTXSID9049243 Css NA 2.83 mg/L 3compartmentss NA 50% Human Human +DTXSID9049243 Css NA 21.6 mg/L 3compartmentss NA 95% Human Human +DTXSID9049243 Css NA 1.876 mg/L PBTK NA 50% Human Human +DTXSID9049243 Css NA 13.58 mg/L PBTK NA 95% Human Human +DTXSID9049243 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049243 Fup 0.00777 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049243 Vd NA 1.908 L/kg 1compartment NA NA Rat Human DTXSID9049243 Days.Css NA 4 Days PBTK NA NA Rat Human -DTXSID9049243 TK.Half.Life NA 8.338 hours 1compartment NA NA Rat Human -DTXSID9049243 Css NA 1.271 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049243 Css NA 6.541 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049243 Css NA 0.8397 mg/L PBTK NA 50% Rat Human -DTXSID9049243 Css NA 4.206 mg/L PBTK NA 95% Rat Human +DTXSID9049243 TK.Half.Life NA 12.08 hours 1compartment NA NA Rat Human +DTXSID9049243 Css NA 0.3724 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049243 Css NA 2.289 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049243 Css NA 0.2402 mg/L PBTK NA 50% Rat Human +DTXSID9049243 Css NA 1.434 mg/L PBTK NA 95% Rat Human DTXSID9049245 Clint NA 134.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9049245 Fup NA 0.021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9049245 Vd NA 6.142 L/kg 1compartment NA NA Human Human DTXSID9049245 Days.Css NA 3 Days PBTK NA NA Human Human DTXSID9049245 TK.Half.Life NA 32.9 hours 1compartment NA NA Human Human -DTXSID9049245 Css NA 0.4384 mg/L 3compartmentss NA 50% Human Human -DTXSID9049245 Css NA 2.559 mg/L 3compartmentss NA 95% Human Human -DTXSID9049245 Css NA 0.39 mg/L PBTK NA 50% Human Human -DTXSID9049245 Css NA 2.2 mg/L PBTK NA 95% Human Human +DTXSID9049245 Css NA 0.4278 mg/L 3compartmentss NA 50% Human Human +DTXSID9049245 Css NA 2.538 mg/L 3compartmentss NA 95% Human Human +DTXSID9049245 Css NA 0.3812 mg/L PBTK NA 50% Human Human +DTXSID9049245 Css NA 2.206 mg/L PBTK NA 95% Human Human DTXSID9049245 Clint NA 134.8 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9049245 Fup NA 0.021 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9049245 Vd NA 4.733 L/kg 1compartment NA NA Rat Human DTXSID9049245 Days.Css NA 2 Days PBTK NA NA Rat Human DTXSID9049245 TK.Half.Life NA 5.131 hours 1compartment NA NA Rat Human -DTXSID9049245 Css NA 0.2437 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049245 Css NA 1.024 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049245 Css NA 0.2131 mg/L PBTK NA 50% Rat Human -DTXSID9049245 Css NA 0.9015 mg/L PBTK NA 95% Rat Human -DTXSID9049249 Clint NA 196.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049249 Fup NA 0.1852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049249 Vd NA 3.138 L/kg 1compartment NA NA Human Human -DTXSID9049249 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049249 TK.Half.Life NA 9.723 hours 1compartment NA NA Human Human -DTXSID9049249 Css NA 0.2824 mg/L 3compartmentss NA 50% Human Human -DTXSID9049249 Css NA 1.774 mg/L 3compartmentss NA 95% Human Human -DTXSID9049249 Css NA 0.1968 mg/L PBTK NA 50% Human Human -DTXSID9049249 Css NA 1.212 mg/L PBTK NA 95% Human Human -DTXSID9049249 Clint NA 196.2 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049249 Fup NA 0.1852 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049249 Vd NA 2.355 L/kg 1compartment NA NA Rat Human -DTXSID9049249 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049249 TK.Half.Life NA 1.755 hours 1compartment NA NA Rat Human -DTXSID9049249 Css NA 0.1574 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049249 Css NA 0.8269 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049249 Css NA 0.1052 mg/L PBTK NA 50% Rat Human -DTXSID9049249 Css NA 0.5288 mg/L PBTK NA 95% Rat Human +DTXSID9049245 Css NA 0.05471 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049245 Css NA 0.2639 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049245 Css NA 0.04933 mg/L PBTK NA 50% Rat Human +DTXSID9049245 Css NA 0.2402 mg/L PBTK NA 95% Rat Human DTXSID9049293 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9049293 Fup NA 0.4547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049293 Vd NA 0.8872 L/kg 1compartment NA NA Human Human +DTXSID9049293 Vd NA 1.01 L/kg 1compartment NA NA Human Human DTXSID9049293 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049293 TK.Half.Life NA 7.091 hours 1compartment NA NA Human Human -DTXSID9049293 Css NA 0.8195 mg/L 3compartmentss NA 50% Human Human -DTXSID9049293 Css NA 4.258 mg/L 3compartmentss NA 95% Human Human -DTXSID9049293 Css NA 0.6476 mg/L PBTK NA 50% Human Human -DTXSID9049293 Css NA 2.773 mg/L PBTK NA 95% Human Human +DTXSID9049293 TK.Half.Life NA 8.235 hours 1compartment NA NA Human Human +DTXSID9049293 Css NA 0.6947 mg/L 3compartmentss NA 50% Human Human +DTXSID9049293 Css NA 3.663 mg/L 3compartmentss NA 95% Human Human +DTXSID9049293 Css NA 0.5577 mg/L PBTK NA 50% Human Human +DTXSID9049293 Css NA 2.397 mg/L PBTK NA 95% Human Human DTXSID9049293 Clint NA 0.5236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9049293 Fup NA 0.4547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049293 Vd NA 0.8202 L/kg 1compartment NA NA Rat Human +DTXSID9049293 Vd NA 0.909 L/kg 1compartment NA NA Rat Human DTXSID9049293 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049293 TK.Half.Life NA 2.831 hours 1compartment NA NA Rat Human -DTXSID9049293 Css NA 0.2947 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049293 Css NA 1.321 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049293 Css NA 0.2249 mg/L PBTK NA 50% Rat Human -DTXSID9049293 Css NA 0.7997 mg/L PBTK NA 95% Rat Human -DTXSID9049295 Clint NA 21.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049295 Fup NA 0.9538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049295 Vd NA 1.437 L/kg 1compartment NA NA Human Human +DTXSID9049293 TK.Half.Life NA 3.149 hours 1compartment NA NA Rat Human +DTXSID9049293 Css NA 0.01714 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049293 Css NA 0.1164 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049293 Css NA 0.01332 mg/L PBTK NA 50% Rat Human +DTXSID9049293 Css NA 0.07704 mg/L PBTK NA 95% Rat Human +DTXSID9049295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049295 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049295 Vd NA 0.8315 L/kg 1compartment NA NA Human Human DTXSID9049295 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049295 TK.Half.Life NA 0.9843 hours 1compartment NA NA Human Human -DTXSID9049295 Css NA 0.0239 mg/L 3compartmentss NA 50% Human Human -DTXSID9049295 Css NA 0.2425 mg/L 3compartmentss NA 95% Human Human -DTXSID9049295 Css NA 0.02196 mg/L PBTK NA 50% Human Human -DTXSID9049295 Css NA 0.1841 mg/L PBTK NA 95% Human Human -DTXSID9049295 Clint NA 21.32 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049295 Fup NA 0.9538 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049295 Vd NA 1.324 L/kg 1compartment NA NA Rat Human +DTXSID9049295 TK.Half.Life NA 0.9591 hours 1compartment NA NA Human Human +DTXSID9049295 Css NA 0.05264 mg/L 3compartmentss NA 50% Human Human +DTXSID9049295 Css NA 0.4021 mg/L 3compartmentss NA 95% Human Human +DTXSID9049295 Css NA 0.03926 mg/L PBTK NA 50% Human Human +DTXSID9049295 Css NA 0.2783 mg/L PBTK NA 95% Human Human +DTXSID9049295 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049295 Fup 0.374 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049295 Vd NA 0.7591 L/kg 1compartment NA NA Rat Human DTXSID9049295 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049295 TK.Half.Life NA 0.4292 hours 1compartment NA NA Rat Human -DTXSID9049295 Css NA 0.012 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049295 Css NA 0.1073 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049295 Css NA 0.011 mg/L PBTK NA 50% Rat Human -DTXSID9049295 Css NA 0.07742 mg/L PBTK NA 95% Rat Human -DTXSID9049297 Clint NA 168.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049297 Fup NA 0.342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049297 Vd NA 1.939 L/kg 1compartment NA NA Human Human -DTXSID9049297 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049297 TK.Half.Life NA 1.543 hours 1compartment NA NA Human Human -DTXSID9049297 Css NA 0.01113 mg/L 3compartmentss NA 50% Human Human -DTXSID9049297 Css NA 0.08162 mg/L 3compartmentss NA 95% Human Human -DTXSID9049297 Css NA 0.008646 mg/L PBTK NA 50% Human Human -DTXSID9049297 Css NA 0.05832 mg/L PBTK NA 95% Human Human -DTXSID9049297 Clint NA 168.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049297 Fup NA 0.342 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049297 Vd NA 1.536 L/kg 1compartment NA NA Rat Human -DTXSID9049297 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049297 TK.Half.Life NA 0.5336 hours 1compartment NA NA Rat Human -DTXSID9049297 Css NA 0.006039 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049297 Css NA 0.03795 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049297 Css NA 0.004523 mg/L PBTK NA 50% Rat Human -DTXSID9049297 Css NA 0.02633 mg/L PBTK NA 95% Rat Human -DTXSID9049299 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049299 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049299 Vd NA 3.157 L/kg 1compartment NA NA Human Human -DTXSID9049299 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049299 TK.Half.Life NA 11.68 hours 1compartment NA NA Human Human -DTXSID9049299 Css NA 0.3557 mg/L 3compartmentss NA 50% Human Human -DTXSID9049299 Css NA 2.326 mg/L 3compartmentss NA 95% Human Human -DTXSID9049299 Css NA 0.2508 mg/L PBTK NA 50% Human Human -DTXSID9049299 Css NA 1.568 mg/L PBTK NA 95% Human Human -DTXSID9049299 Clint NA 96.94 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049299 Fup NA 0.5725 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049299 Vd NA 2.375 L/kg 1compartment NA NA Rat Human -DTXSID9049299 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049299 TK.Half.Life NA 2.005 hours 1compartment NA NA Rat Human -DTXSID9049299 Css NA 0.199 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049299 Css NA 1.077 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049299 Css NA 0.1344 mg/L PBTK NA 50% Rat Human -DTXSID9049299 Css NA 0.7061 mg/L PBTK NA 95% Rat Human -DTXSID9049322 Clint NA 34.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049322 Fup NA 0.1775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049322 Vd NA 2.277 L/kg 1compartment NA NA Human Human -DTXSID9049322 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049322 TK.Half.Life NA 4.311 hours 1compartment NA NA Human Human -DTXSID9049322 Css NA 0.14 mg/L 3compartmentss NA 50% Human Human -DTXSID9049322 Css NA 0.902 mg/L 3compartmentss NA 95% Human Human -DTXSID9049322 Css NA 0.1006 mg/L PBTK NA 50% Human Human -DTXSID9049322 Css NA 0.6149 mg/L PBTK NA 95% Human Human -DTXSID9049322 Clint NA 34.16 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049322 Fup NA 0.1775 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049322 Vd NA 1.738 L/kg 1compartment NA NA Rat Human -DTXSID9049322 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049322 TK.Half.Life NA 1.34 hours 1compartment NA NA Rat Human -DTXSID9049322 Css NA 0.07802 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049322 Css NA 0.4002 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049322 Css NA 0.05367 mg/L PBTK NA 50% Rat Human -DTXSID9049322 Css NA 0.2593 mg/L PBTK NA 95% Rat Human -DTXSID9049324 Clint NA 0.6977 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049324 Fup NA 0.3744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049324 Vd NA 0.6214 L/kg 1compartment NA NA Human Human +DTXSID9049295 TK.Half.Life NA 0.451 hours 1compartment NA NA Rat Human +DTXSID9049295 Css NA 0.00648 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049295 Css NA 0.039 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049295 Css NA 0.004884 mg/L PBTK NA 50% Rat Human +DTXSID9049295 Css NA 0.02634 mg/L PBTK NA 95% Rat Human +DTXSID9049324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049324 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049324 Vd NA 0.5542 L/kg 1compartment NA NA Human Human DTXSID9049324 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049324 TK.Half.Life NA 5.173 hours 1compartment NA NA Human Human -DTXSID9049324 Css NA 0.9194 mg/L 3compartmentss NA 50% Human Human -DTXSID9049324 Css NA 4.228 mg/L 3compartmentss NA 95% Human Human -DTXSID9049324 Css NA 0.6693 mg/L PBTK NA 50% Human Human -DTXSID9049324 Css NA 2.694 mg/L PBTK NA 95% Human Human -DTXSID9049324 Clint NA 0.6977 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049324 Fup NA 0.3744 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049324 Vd NA 0.5816 L/kg 1compartment NA NA Rat Human +DTXSID9049324 TK.Half.Life NA 0.7342 hours 1compartment NA NA Human Human +DTXSID9049324 Css NA 0.06901 mg/L 3compartmentss NA 50% Human Human +DTXSID9049324 Css NA 0.5092 mg/L 3compartmentss NA 95% Human Human +DTXSID9049324 Css NA 0.04758 mg/L PBTK NA 50% Human Human +DTXSID9049324 Css NA 0.3399 mg/L PBTK NA 95% Human Human +DTXSID9049324 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049324 Fup 0.303 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049324 Vd NA 0.5179 L/kg 1compartment NA NA Rat Human DTXSID9049324 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049324 TK.Half.Life NA 2.22 hours 1compartment NA NA Rat Human -DTXSID9049324 Css NA 0.3491 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049324 Css NA 1.351 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049324 Css NA 0.2425 mg/L PBTK NA 50% Rat Human -DTXSID9049324 Css NA 0.7968 mg/L PBTK NA 95% Rat Human -DTXSID9049326 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049326 Fup NA 0.8789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049326 Vd NA 0.8469 L/kg 1compartment NA NA Human Human +DTXSID9049324 TK.Half.Life NA 0.3614 hours 1compartment NA NA Rat Human +DTXSID9049324 Css NA 0.008705 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049324 Css NA 0.04985 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049324 Css NA 0.005979 mg/L PBTK NA 50% Rat Human +DTXSID9049324 Css NA 0.03208 mg/L PBTK NA 95% Rat Human +DTXSID9049326 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049326 Fup 0.83 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049326 Vd NA 0.8234 L/kg 1compartment NA NA Human Human DTXSID9049326 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049326 TK.Half.Life NA 6.261 hours 1compartment NA NA Human Human -DTXSID9049326 Css NA 0.9076 mg/L 3compartmentss NA 50% Human Human -DTXSID9049326 Css NA 5.338 mg/L 3compartmentss NA 95% Human Human -DTXSID9049326 Css NA 0.7721 mg/L PBTK NA 50% Human Human -DTXSID9049326 Css NA 3.461 mg/L PBTK NA 95% Human Human -DTXSID9049326 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049326 Fup NA 0.8789 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049326 Vd NA 0.8625 L/kg 1compartment NA NA Rat Human +DTXSID9049326 TK.Half.Life NA 6.448 hours 1compartment NA NA Human Human +DTXSID9049326 Css NA 0.8087 mg/L 3compartmentss NA 50% Human Human +DTXSID9049326 Css NA 5 mg/L 3compartmentss NA 95% Human Human +DTXSID9049326 Css NA 0.684 mg/L PBTK NA 50% Human Human +DTXSID9049326 Css NA 3.224 mg/L PBTK NA 95% Human Human +DTXSID9049326 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049326 Fup 0.83 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049326 Vd NA 0.8368 L/kg 1compartment NA NA Rat Human DTXSID9049326 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049326 TK.Half.Life NA 2.166 hours 1compartment NA NA Rat Human -DTXSID9049326 Css NA 0.2332 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049326 Css NA 1.356 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049326 Css NA 0.1927 mg/L PBTK NA 50% Rat Human -DTXSID9049326 Css NA 0.8233 mg/L PBTK NA 95% Rat Human -DTXSID9049374 Clint NA 7.919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049374 Fup NA 0.4068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049374 Vd NA 2.207 L/kg 1compartment NA NA Human Human +DTXSID9049326 TK.Half.Life NA 2.225 hours 1compartment NA NA Rat Human +DTXSID9049326 Css NA 0.01507 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049326 Css NA 0.1194 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049326 Css NA 0.01228 mg/L PBTK NA 50% Rat Human +DTXSID9049326 Css NA 0.07724 mg/L PBTK NA 95% Rat Human +DTXSID9049374 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049374 Fup 0.438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049374 Vd NA 2.268 L/kg 1compartment NA NA Human Human DTXSID9049374 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049374 TK.Half.Life NA 3.721 hours 1compartment NA NA Human Human -DTXSID9049374 Css NA 0.114 mg/L 3compartmentss NA 50% Human Human -DTXSID9049374 Css NA 0.8187 mg/L 3compartmentss NA 95% Human Human -DTXSID9049374 Css NA 0.1066 mg/L PBTK NA 50% Human Human -DTXSID9049374 Css NA 0.6424 mg/L PBTK NA 95% Human Human -DTXSID9049374 Clint NA 7.919 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049374 Fup NA 0.4068 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049374 Vd NA 2.13 L/kg 1compartment NA NA Rat Human +DTXSID9049374 TK.Half.Life NA 2.147 hours 1compartment NA NA Human Human +DTXSID9049374 Css NA 0.03686 mg/L 3compartmentss NA 50% Human Human +DTXSID9049374 Css NA 0.3343 mg/L 3compartmentss NA 95% Human Human +DTXSID9049374 Css NA 0.03552 mg/L PBTK NA 50% Human Human +DTXSID9049374 Css NA 0.2662 mg/L PBTK NA 95% Human Human +DTXSID9049374 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049374 Fup 0.438 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049374 Vd NA 2.196 L/kg 1compartment NA NA Rat Human DTXSID9049374 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049374 TK.Half.Life NA 1.949 hours 1compartment NA NA Rat Human -DTXSID9049374 Css NA 0.0562 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049374 Css NA 0.3225 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049374 Css NA 0.05205 mg/L PBTK NA 50% Rat Human -DTXSID9049374 Css NA 0.2325 mg/L PBTK NA 95% Rat Human -DTXSID9049376 Clint NA 0.1406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049376 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049376 Vd NA 1.045 L/kg 1compartment NA NA Human Human +DTXSID9049374 TK.Half.Life NA 1.065 hours 1compartment NA NA Rat Human +DTXSID9049374 Css NA 0.004486 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049374 Css NA 0.03138 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049374 Css NA 0.004422 mg/L PBTK NA 50% Rat Human +DTXSID9049374 Css NA 0.02489 mg/L PBTK NA 95% Rat Human +DTXSID9049376 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049376 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049376 Vd NA 0.8076 L/kg 1compartment NA NA Human Human DTXSID9049376 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049376 TK.Half.Life NA 5.59 hours 1compartment NA NA Human Human -DTXSID9049376 Css NA 0.6176 mg/L 3compartmentss NA 50% Human Human -DTXSID9049376 Css NA 4.31 mg/L 3compartmentss NA 95% Human Human -DTXSID9049376 Css NA 0.5564 mg/L PBTK NA 50% Human Human -DTXSID9049376 Css NA 2.885 mg/L PBTK NA 95% Human Human -DTXSID9049376 Clint NA 0.1406 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049376 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049376 Vd NA 1.039 L/kg 1compartment NA NA Rat Human +DTXSID9049376 TK.Half.Life NA 8.126 hours 1compartment NA NA Human Human +DTXSID9049376 Css NA 1.106 mg/L 3compartmentss NA 50% Human Human +DTXSID9049376 Css NA 7.283 mg/L 3compartmentss NA 95% Human Human +DTXSID9049376 Css NA 0.9104 mg/L PBTK NA 50% Human Human +DTXSID9049376 Css NA 4.658 mg/L PBTK NA 95% Human Human +DTXSID9049376 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049376 Fup 0.65 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049376 Vd NA 0.7998 L/kg 1compartment NA NA Rat Human DTXSID9049376 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049376 TK.Half.Life NA 2.068 hours 1compartment NA NA Rat Human -DTXSID9049376 Css NA 0.1753 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049376 Css NA 1.206 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049376 Css NA 0.1552 mg/L PBTK NA 50% Rat Human -DTXSID9049376 Css NA 0.7391 mg/L PBTK NA 95% Rat Human -DTXSID9049401 Clint NA 14.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049401 Fup NA 0.0389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049401 Vd NA 3.129 L/kg 1compartment NA NA Human Human -DTXSID9049401 Days.Css NA 26 Days PBTK NA NA Human Human -DTXSID9049401 TK.Half.Life NA 139.9 hours 1compartment NA NA Human Human -DTXSID9049401 Css NA 5.4 mg/L 3compartmentss NA 50% Human Human -DTXSID9049401 Css NA 31.11 mg/L 3compartmentss NA 95% Human Human -DTXSID9049401 Css NA 3.768 mg/L PBTK NA 50% Human Human -DTXSID9049401 Css NA 21.49 mg/L PBTK NA 95% Human Human -DTXSID9049401 Clint NA 14.12 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049401 Fup NA 0.0389 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049401 Vd NA 2.344 L/kg 1compartment NA NA Rat Human -DTXSID9049401 Days.Css NA 14 Days PBTK NA NA Rat Human -DTXSID9049401 TK.Half.Life NA 18.29 hours 1compartment NA NA Rat Human -DTXSID9049401 Css NA 3.034 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049401 Css NA 13.91 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049401 Css NA 2.017 mg/L PBTK NA 50% Rat Human -DTXSID9049401 Css NA 9.14 mg/L PBTK NA 95% Rat Human -DTXSID9049405 Clint NA 1.581 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049405 Fup NA 0.8697 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049405 Vd NA 0.79 L/kg 1compartment NA NA Human Human +DTXSID9049376 TK.Half.Life NA 2.72 hours 1compartment NA NA Rat Human +DTXSID9049376 Css NA 0.06628 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049376 Css NA 0.4157 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049376 Css NA 0.05464 mg/L PBTK NA 50% Rat Human +DTXSID9049376 Css NA 0.256 mg/L PBTK NA 95% Rat Human +DTXSID9049401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049401 Fup 0.0763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049401 Vd NA 2.419 L/kg 1compartment NA NA Human Human +DTXSID9049401 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9049401 TK.Half.Life NA 10.41 hours 1compartment NA NA Human Human +DTXSID9049401 Css NA 0.4916 mg/L 3compartmentss NA 50% Human Human +DTXSID9049401 Css NA 3.326 mg/L 3compartmentss NA 95% Human Human +DTXSID9049401 Css NA 0.345 mg/L PBTK NA 50% Human Human +DTXSID9049401 Css NA 2.203 mg/L PBTK NA 95% Human Human +DTXSID9049401 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049401 Fup 0.0763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049401 Vd NA 1.904 L/kg 1compartment NA NA Rat Human +DTXSID9049401 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9049401 TK.Half.Life NA 3.337 hours 1compartment NA NA Rat Human +DTXSID9049401 Css NA 0.06325 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049401 Css NA 0.3389 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049401 Css NA 0.04377 mg/L PBTK NA 50% Rat Human +DTXSID9049401 Css NA 0.2281 mg/L PBTK NA 95% Rat Human +DTXSID9049403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049403 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049403 Vd NA 1.494 L/kg 1compartment NA NA Human Human +DTXSID9049403 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9049403 TK.Half.Life NA 3.553 hours 1compartment NA NA Human Human +DTXSID9049403 Css NA 0.2297 mg/L 3compartmentss NA 50% Human Human +DTXSID9049403 Css NA 1.747 mg/L 3compartmentss NA 95% Human Human +DTXSID9049403 Css NA 0.1552 mg/L PBTK NA 50% Human Human +DTXSID9049403 Css NA 1.11 mg/L PBTK NA 95% Human Human +DTXSID9049403 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049403 Fup 0.129 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049403 Vd NA 1.156 L/kg 1compartment NA NA Rat Human +DTXSID9049403 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9049403 TK.Half.Life NA 1.387 hours 1compartment NA NA Rat Human +DTXSID9049403 Css NA 0.02944 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049403 Css NA 0.1751 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049403 Css NA 0.01965 mg/L PBTK NA 50% Rat Human +DTXSID9049403 Css NA 0.1094 mg/L PBTK NA 95% Rat Human +DTXSID9049405 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049405 Fup 0.668 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049405 Vd NA 0.7517 L/kg 1compartment NA NA Human Human DTXSID9049405 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049405 TK.Half.Life NA 1.874 hours 1compartment NA NA Human Human -DTXSID9049405 Css NA 0.27 mg/L 3compartmentss NA 50% Human Human -DTXSID9049405 Css NA 1.785 mg/L 3compartmentss NA 95% Human Human -DTXSID9049405 Css NA 0.2238 mg/L PBTK NA 50% Human Human -DTXSID9049405 Css NA 1.181 mg/L PBTK NA 95% Human Human -DTXSID9049405 Clint NA 1.581 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049405 Fup NA 0.8697 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049405 Vd NA 0.8113 L/kg 1compartment NA NA Rat Human +DTXSID9049405 TK.Half.Life NA 7.331 hours 1compartment NA NA Human Human +DTXSID9049405 Css NA 1.084 mg/L 3compartmentss NA 50% Human Human +DTXSID9049405 Css NA 7.252 mg/L 3compartmentss NA 95% Human Human +DTXSID9049405 Css NA 0.8855 mg/L PBTK NA 50% Human Human +DTXSID9049405 Css NA 4.611 mg/L PBTK NA 95% Human Human +DTXSID9049405 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049405 Fup 0.668 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049405 Vd NA 0.7524 L/kg 1compartment NA NA Rat Human DTXSID9049405 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049405 TK.Half.Life NA 0.9726 hours 1compartment NA NA Rat Human -DTXSID9049405 Css NA 0.1077 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049405 Css NA 0.6406 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049405 Css NA 0.08806 mg/L PBTK NA 50% Rat Human -DTXSID9049405 Css NA 0.3889 mg/L PBTK NA 95% Rat Human -DTXSID9049407 Clint NA 2.257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049407 Fup NA 0.6991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9049407 Vd NA 0.9104 L/kg 1compartment NA NA Human Human +DTXSID9049405 TK.Half.Life NA 2.487 hours 1compartment NA NA Rat Human +DTXSID9049405 Css NA 0.06612 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049405 Css NA 0.4091 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049405 Css NA 0.05366 mg/L PBTK NA 50% Rat Human +DTXSID9049405 Css NA 0.251 mg/L PBTK NA 95% Rat Human +DTXSID9049407 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049407 Fup 0.336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9049407 Vd NA 0.5944 L/kg 1compartment NA NA Human Human DTXSID9049407 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9049407 TK.Half.Life NA 2.147 hours 1compartment NA NA Human Human -DTXSID9049407 Css NA 0.2358 mg/L 3compartmentss NA 50% Human Human -DTXSID9049407 Css NA 1.752 mg/L 3compartmentss NA 95% Human Human -DTXSID9049407 Css NA 0.1969 mg/L PBTK NA 50% Human Human -DTXSID9049407 Css NA 1.151 mg/L PBTK NA 95% Human Human -DTXSID9049407 Clint NA 2.257 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049407 Fup NA 0.6991 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9049407 Vd NA 0.888 L/kg 1compartment NA NA Rat Human +DTXSID9049407 TK.Half.Life NA 1.385 hours 1compartment NA NA Human Human +DTXSID9049407 Css NA 0.1987 mg/L 3compartmentss NA 50% Human Human +DTXSID9049407 Css NA 1.279 mg/L 3compartmentss NA 95% Human Human +DTXSID9049407 Css NA 0.1427 mg/L PBTK NA 50% Human Human +DTXSID9049407 Css NA 0.8435 mg/L PBTK NA 95% Human Human +DTXSID9049407 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049407 Fup 0.336 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9049407 Vd NA 0.5766 L/kg 1compartment NA NA Rat Human DTXSID9049407 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9049407 TK.Half.Life NA 1.093 hours 1compartment NA NA Rat Human -DTXSID9049407 Css NA 0.1006 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049407 Css NA 0.7094 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049407 Css NA 0.08248 mg/L PBTK NA 50% Rat Human -DTXSID9049407 Css NA 0.431 mg/L PBTK NA 95% Rat Human +DTXSID9049407 TK.Half.Life NA 0.7581 hours 1compartment NA NA Rat Human +DTXSID9049407 Css NA 0.02332 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049407 Css NA 0.1114 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049407 Css NA 0.01657 mg/L PBTK NA 50% Rat Human +DTXSID9049407 Css NA 0.07056 mg/L PBTK NA 95% Rat Human DTXSID9049409 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9049409 Fup NA 0.673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9049409 Vd NA 0.431 L/kg 1compartment NA NA Human Human DTXSID9049409 Days.Css NA 0 Days PBTK NA NA Human Human DTXSID9049409 TK.Half.Life NA 4.143 hours 1compartment NA NA Human Human -DTXSID9049409 Css NA 1.235 mg/L 3compartmentss NA 50% Human Human -DTXSID9049409 Css NA 7.647 mg/L 3compartmentss NA 95% Human Human -DTXSID9049409 Css NA 0.8994 mg/L PBTK NA 50% Human Human -DTXSID9049409 Css NA 4.674 mg/L PBTK NA 95% Human Human +DTXSID9049409 Css NA 1.06 mg/L 3compartmentss NA 50% Human Human +DTXSID9049409 Css NA 6.522 mg/L 3compartmentss NA 95% Human Human +DTXSID9049409 Css NA 0.7703 mg/L PBTK NA 50% Human Human +DTXSID9049409 Css NA 3.955 mg/L PBTK NA 95% Human Human DTXSID9049409 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9049409 Fup NA 0.673 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9049409 Vd NA 0.4472 L/kg 1compartment NA NA Rat Human DTXSID9049409 Days.Css NA 0 Days PBTK NA NA Rat Human DTXSID9049409 TK.Half.Life NA 1.465 hours 1compartment NA NA Rat Human -DTXSID9049409 Css NA 0.3269 mg/L 3compartmentss NA 50% Rat Human -DTXSID9049409 Css NA 1.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID9049409 Css NA 0.227 mg/L PBTK NA 50% Rat Human -DTXSID9049409 Css NA 1.087 mg/L PBTK NA 95% Rat Human +DTXSID9049409 Css NA 0.02016 mg/L 3compartmentss NA 50% Rat Human +DTXSID9049409 Css NA 0.159 mg/L 3compartmentss NA 95% Rat Human +DTXSID9049409 Css NA 0.01408 mg/L PBTK NA 50% Rat Human +DTXSID9049409 Css NA 0.097 mg/L PBTK NA 95% Rat Human DTXSID9051662 Clint NA 0.1236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9051662 Fup NA 0.599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9051662 Vd NA 0.4448 L/kg 1compartment NA NA Human Human +DTXSID9051662 Vd NA 0.4461 L/kg 1compartment NA NA Human Human DTXSID9051662 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9051662 TK.Half.Life NA 3.997 hours 1compartment NA NA Human Human -DTXSID9051662 Css NA 1.108 mg/L 3compartmentss NA 50% Human Human -DTXSID9051662 Css NA 6.752 mg/L 3compartmentss NA 95% Human Human -DTXSID9051662 Css NA 0.8004 mg/L PBTK NA 50% Human Human -DTXSID9051662 Css NA 4.134 mg/L PBTK NA 95% Human Human +DTXSID9051662 TK.Half.Life NA 4.011 hours 1compartment NA NA Human Human +DTXSID9051662 Css NA 0.9291 mg/L 3compartmentss NA 50% Human Human +DTXSID9051662 Css NA 6.159 mg/L 3compartmentss NA 95% Human Human +DTXSID9051662 Css NA 0.6774 mg/L PBTK NA 50% Human Human +DTXSID9051662 Css NA 3.751 mg/L PBTK NA 95% Human Human DTXSID9051662 Clint NA 0.1236 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9051662 Fup NA 0.599 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9051662 Vd NA 0.4569 L/kg 1compartment NA NA Rat Human +DTXSID9051662 Vd NA 0.4581 L/kg 1compartment NA NA Rat Human DTXSID9051662 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9051662 TK.Half.Life NA 1.531 hours 1compartment NA NA Rat Human -DTXSID9051662 Css NA 0.3274 mg/L 3compartmentss NA 50% Rat Human -DTXSID9051662 Css NA 2.043 mg/L 3compartmentss NA 95% Rat Human -DTXSID9051662 Css NA 0.2252 mg/L PBTK NA 50% Rat Human -DTXSID9051662 Css NA 1.163 mg/L PBTK NA 95% Rat Human -DTXSID9051824 Clint NA 0.9018 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9051824 Fup NA 0.8372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9051824 Vd NA 1.544 L/kg 1compartment NA NA Human Human +DTXSID9051662 TK.Half.Life NA 1.536 hours 1compartment NA NA Rat Human +DTXSID9051662 Css NA 0.01981 mg/L 3compartmentss NA 50% Rat Human +DTXSID9051662 Css NA 0.1646 mg/L 3compartmentss NA 95% Rat Human +DTXSID9051662 Css NA 0.0137 mg/L PBTK NA 50% Rat Human +DTXSID9051662 Css NA 0.09904 mg/L PBTK NA 95% Rat Human +DTXSID9051824 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9051824 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9051824 Vd NA 0.9833 L/kg 1compartment NA NA Human Human DTXSID9051824 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9051824 TK.Half.Life NA 5.724 hours 1compartment NA NA Human Human -DTXSID9051824 Css NA 0.3672 mg/L 3compartmentss NA 50% Human Human -DTXSID9051824 Css NA 2.432 mg/L 3compartmentss NA 95% Human Human -DTXSID9051824 Css NA 0.3412 mg/L PBTK NA 50% Human Human -DTXSID9051824 Css NA 1.671 mg/L PBTK NA 95% Human Human -DTXSID9051824 Clint NA 0.9018 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9051824 Fup NA 0.8372 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9051824 Vd NA 1.377 L/kg 1compartment NA NA Rat Human +DTXSID9051824 TK.Half.Life NA 1.128 hours 1compartment NA NA Human Human +DTXSID9051824 Css NA 0.05195 mg/L 3compartmentss NA 50% Human Human +DTXSID9051824 Css NA 0.3951 mg/L 3compartmentss NA 95% Human Human +DTXSID9051824 Css NA 0.04001 mg/L PBTK NA 50% Human Human +DTXSID9051824 Css NA 0.2702 mg/L PBTK NA 95% Human Human +DTXSID9051824 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9051824 Fup 0.378 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9051824 Vd NA 0.8693 L/kg 1compartment NA NA Rat Human DTXSID9051824 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9051824 TK.Half.Life NA 2.21 hours 1compartment NA NA Rat Human -DTXSID9051824 Css NA 0.1345 mg/L 3compartmentss NA 50% Rat Human -DTXSID9051824 Css NA 0.8479 mg/L 3compartmentss NA 95% Rat Human -DTXSID9051824 Css NA 0.1246 mg/L PBTK NA 50% Rat Human -DTXSID9051824 Css NA 0.5381 mg/L PBTK NA 95% Rat Human -DTXSID9052509 Clint NA 2.327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9052509 Fup NA 0.5547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9052509 Vd NA 1.295 L/kg 1compartment NA NA Human Human +DTXSID9051824 TK.Half.Life NA 0.5089 hours 1compartment NA NA Rat Human +DTXSID9051824 Css NA 0.006476 mg/L 3compartmentss NA 50% Rat Human +DTXSID9051824 Css NA 0.03824 mg/L 3compartmentss NA 95% Rat Human +DTXSID9051824 Css NA 0.004988 mg/L PBTK NA 50% Rat Human +DTXSID9051824 Css NA 0.0259 mg/L PBTK NA 95% Rat Human +DTXSID9052052 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052052 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052052 Vd NA 0.283 L/kg 1compartment NA NA Human Human +DTXSID9052052 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9052052 TK.Half.Life NA 0.9837 hours 1compartment NA NA Human Human +DTXSID9052052 Css NA 0.3617 mg/L 3compartmentss NA 50% Human Human +DTXSID9052052 Css NA 2.114 mg/L 3compartmentss NA 95% Human Human +DTXSID9052052 Css NA 0.229 mg/L PBTK NA 50% Human Human +DTXSID9052052 Css NA 1.301 mg/L PBTK NA 95% Human Human +DTXSID9052052 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052052 Fup 0.203 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052052 Vd NA 0.2872 L/kg 1compartment NA NA Rat Human +DTXSID9052052 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9052052 TK.Half.Life NA 0.5839 hours 1compartment NA NA Rat Human +DTXSID9052052 Css NA 0.04332 mg/L 3compartmentss NA 50% Rat Human +DTXSID9052052 Css NA 0.1787 mg/L 3compartmentss NA 95% Rat Human +DTXSID9052052 Css NA 0.02703 mg/L PBTK NA 50% Rat Human +DTXSID9052052 Css NA 0.1068 mg/L PBTK NA 95% Rat Human +DTXSID9052399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052399 Fup 0.00663 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052399 Vd NA 4.285 L/kg 1compartment NA NA Human Human +DTXSID9052399 Days.Css NA 23 Days PBTK NA NA Human Human +DTXSID9052399 TK.Half.Life NA 130.5 hours 1compartment NA NA Human Human +DTXSID9052399 Css NA 3.148 mg/L 3compartmentss NA 50% Human Human +DTXSID9052399 Css NA 19.05 mg/L 3compartmentss NA 95% Human Human +DTXSID9052399 Css NA 2.425 mg/L PBTK NA 50% Human Human +DTXSID9052399 Css NA 14.38 mg/L PBTK NA 95% Human Human +DTXSID9052399 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052399 Fup 0.00663 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052399 Vd NA 3.25 L/kg 1compartment NA NA Rat Human +DTXSID9052399 Days.Css NA 13 Days PBTK NA NA Rat Human +DTXSID9052399 TK.Half.Life NA 18.27 hours 1compartment NA NA Rat Human +DTXSID9052399 Css NA 0.415 mg/L 3compartmentss NA 50% Rat Human +DTXSID9052399 Css NA 2.109 mg/L 3compartmentss NA 95% Rat Human +DTXSID9052399 Css NA 0.3153 mg/L PBTK NA 50% Rat Human +DTXSID9052399 Css NA 1.651 mg/L PBTK NA 95% Rat Human +DTXSID9052476 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052476 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052476 Vd NA 0.5996 L/kg 1compartment NA NA Human Human +DTXSID9052476 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9052476 TK.Half.Life NA 6.211 hours 1compartment NA NA Human Human +DTXSID9052476 Css NA 0.6587 mg/L 3compartmentss NA 50% Human Human +DTXSID9052476 Css NA 4.577 mg/L 3compartmentss NA 95% Human Human +DTXSID9052476 Css NA 0.5165 mg/L PBTK NA 50% Human Human +DTXSID9052476 Css NA 2.875 mg/L PBTK NA 95% Human Human +DTXSID9052476 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052476 Fup 0.625 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052476 Vd NA 0.6248 L/kg 1compartment NA NA Rat Human +DTXSID9052476 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9052476 TK.Half.Life NA 2.204 hours 1compartment NA NA Rat Human +DTXSID9052476 Css NA 0.0035 mg/L 3compartmentss NA 50% Rat Human +DTXSID9052476 Css NA 0.02506 mg/L 3compartmentss NA 95% Rat Human +DTXSID9052476 Css NA 0.002626 mg/L PBTK NA 50% Rat Human +DTXSID9052476 Css NA 0.01514 mg/L PBTK NA 95% Rat Human +DTXSID9052509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052509 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052509 Vd NA 0.9399 L/kg 1compartment NA NA Human Human DTXSID9052509 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9052509 TK.Half.Life NA 3.952 hours 1compartment NA NA Human Human -DTXSID9052509 Css NA 0.2878 mg/L 3compartmentss NA 50% Human Human -DTXSID9052509 Css NA 2.175 mg/L 3compartmentss NA 95% Human Human -DTXSID9052509 Css NA 0.2416 mg/L PBTK NA 50% Human Human -DTXSID9052509 Css NA 1.451 mg/L PBTK NA 95% Human Human -DTXSID9052509 Clint NA 2.327 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9052509 Fup NA 0.5547 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9052509 Vd NA 1.126 L/kg 1compartment NA NA Rat Human +DTXSID9052509 TK.Half.Life NA 1.207 hours 1compartment NA NA Human Human +DTXSID9052509 Css NA 0.06551 mg/L 3compartmentss NA 50% Human Human +DTXSID9052509 Css NA 0.5124 mg/L 3compartmentss NA 95% Human Human +DTXSID9052509 Css NA 0.04824 mg/L PBTK NA 50% Human Human +DTXSID9052509 Css NA 0.3452 mg/L PBTK NA 95% Human Human +DTXSID9052509 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052509 Fup 0.312 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052509 Vd NA 0.8121 L/kg 1compartment NA NA Rat Human DTXSID9052509 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9052509 TK.Half.Life NA 1.705 hours 1compartment NA NA Rat Human -DTXSID9052509 Css NA 0.1292 mg/L 3compartmentss NA 50% Rat Human -DTXSID9052509 Css NA 0.8435 mg/L 3compartmentss NA 95% Rat Human -DTXSID9052509 Css NA 0.1053 mg/L PBTK NA 50% Rat Human -DTXSID9052509 Css NA 0.5103 mg/L PBTK NA 95% Rat Human -DTXSID9057630 Clint NA 4.513 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057630 Fup NA 0.0866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057630 Vd NA 0.5978 L/kg 1compartment NA NA Human Human +DTXSID9052509 TK.Half.Life NA 0.5403 hours 1compartment NA NA Rat Human +DTXSID9052509 Css NA 0.008248 mg/L 3compartmentss NA 50% Rat Human +DTXSID9052509 Css NA 0.04725 mg/L 3compartmentss NA 95% Rat Human +DTXSID9052509 Css NA 0.006038 mg/L PBTK NA 50% Rat Human +DTXSID9052509 Css NA 0.03168 mg/L PBTK NA 95% Rat Human +DTXSID9052555 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052555 Fup 0.0726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052555 Vd NA 0.2806 L/kg 1compartment NA NA Human Human +DTXSID9052555 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9052555 TK.Half.Life NA 2.409 hours 1compartment NA NA Human Human +DTXSID9052555 Css NA 1.346 mg/L 3compartmentss NA 50% Human Human +DTXSID9052555 Css NA 8.842 mg/L 3compartmentss NA 95% Human Human +DTXSID9052555 Css NA 0.807 mg/L PBTK NA 50% Human Human +DTXSID9052555 Css NA 5.247 mg/L PBTK NA 95% Human Human +DTXSID9052555 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052555 Fup 0.0726 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052555 Vd NA 0.268 L/kg 1compartment NA NA Rat Human +DTXSID9052555 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9052555 TK.Half.Life NA 1.419 hours 1compartment NA NA Rat Human +DTXSID9052555 Css NA 0.1657 mg/L 3compartmentss NA 50% Rat Human +DTXSID9052555 Css NA 0.83 mg/L 3compartmentss NA 95% Rat Human +DTXSID9052555 Css NA 0.09716 mg/L PBTK NA 50% Rat Human +DTXSID9052555 Css NA 0.4736 mg/L PBTK NA 95% Rat Human +DTXSID9052682 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052682 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9052682 Vd NA 3.026 L/kg 1compartment NA NA Human Human +DTXSID9052682 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID9052682 TK.Half.Life NA 70.06 hours 1compartment NA NA Human Human +DTXSID9052682 Css NA 2.842 mg/L 3compartmentss NA 50% Human Human +DTXSID9052682 Css NA 19 mg/L 3compartmentss NA 95% Human Human +DTXSID9052682 Css NA 1.961 mg/L PBTK NA 50% Human Human +DTXSID9052682 Css NA 12.55 mg/L PBTK NA 95% Human Human +DTXSID9052682 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052682 Fup 0.0152 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9052682 Vd NA 2.265 L/kg 1compartment NA NA Rat Human +DTXSID9052682 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID9052682 TK.Half.Life NA 10.74 hours 1compartment NA NA Rat Human +DTXSID9052682 Css NA 0.368 mg/L 3compartmentss NA 50% Rat Human +DTXSID9052682 Css NA 2.166 mg/L 3compartmentss NA 95% Rat Human +DTXSID9052682 Css NA 0.2501 mg/L PBTK NA 50% Rat Human +DTXSID9052682 Css NA 1.424 mg/L PBTK NA 95% Rat Human +DTXSID9057630 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057630 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057630 Vd NA 0.6957 L/kg 1compartment NA NA Human Human DTXSID9057630 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057630 TK.Half.Life NA 5.64 hours 1compartment NA NA Human Human -DTXSID9057630 Css NA 1.452 mg/L 3compartmentss NA 50% Human Human -DTXSID9057630 Css NA 9.377 mg/L 3compartmentss NA 95% Human Human -DTXSID9057630 Css NA 0.9146 mg/L PBTK NA 50% Human Human -DTXSID9057630 Css NA 5.593 mg/L PBTK NA 95% Human Human -DTXSID9057630 Clint NA 4.513 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057630 Fup NA 0.0866 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057630 Vd NA 0.4977 L/kg 1compartment NA NA Rat Human +DTXSID9057630 TK.Half.Life NA 3.988 hours 1compartment NA NA Human Human +DTXSID9057630 Css NA 0.7796 mg/L 3compartmentss NA 50% Human Human +DTXSID9057630 Css NA 5.453 mg/L 3compartmentss NA 95% Human Human +DTXSID9057630 Css NA 0.5026 mg/L PBTK NA 50% Human Human +DTXSID9057630 Css NA 3.333 mg/L PBTK NA 95% Human Human +DTXSID9057630 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057630 Fup 0.114 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057630 Vd NA 0.5783 L/kg 1compartment NA NA Rat Human DTXSID9057630 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057630 TK.Half.Life NA 2.768 hours 1compartment NA NA Rat Human -DTXSID9057630 Css NA 0.7565 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057630 Css NA 3.695 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057630 Css NA 0.4464 mg/L PBTK NA 50% Rat Human -DTXSID9057630 Css NA 2.056 mg/L PBTK NA 95% Rat Human -DTXSID9057632 Clint NA 0.08113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057632 Fup NA 0.7535 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057632 Vd NA 1.08 L/kg 1compartment NA NA Human Human +DTXSID9057630 TK.Half.Life NA 1.949 hours 1compartment NA NA Rat Human +DTXSID9057630 Css NA 0.0954 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057630 Css NA 0.497 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057630 Css NA 0.05965 mg/L PBTK NA 50% Rat Human +DTXSID9057630 Css NA 0.2907 mg/L PBTK NA 95% Rat Human +DTXSID9057632 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057632 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057632 Vd NA 0.7732 L/kg 1compartment NA NA Human Human DTXSID9057632 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057632 TK.Half.Life NA 8.497 hours 1compartment NA NA Human Human -DTXSID9057632 Css NA 0.8462 mg/L 3compartmentss NA 50% Human Human -DTXSID9057632 Css NA 5.458 mg/L 3compartmentss NA 95% Human Human -DTXSID9057632 Css NA 0.7439 mg/L PBTK NA 50% Human Human -DTXSID9057632 Css NA 3.517 mg/L PBTK NA 95% Human Human -DTXSID9057632 Clint NA 0.08113 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057632 Fup NA 0.7535 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057632 Vd NA 1.025 L/kg 1compartment NA NA Rat Human +DTXSID9057632 TK.Half.Life NA 0.8054 hours 1compartment NA NA Human Human +DTXSID9057632 Css NA 0.04162 mg/L 3compartmentss NA 50% Human Human +DTXSID9057632 Css NA 0.373 mg/L 3compartmentss NA 95% Human Human +DTXSID9057632 Css NA 0.03223 mg/L PBTK NA 50% Human Human +DTXSID9057632 Css NA 0.2544 mg/L PBTK NA 95% Human Human +DTXSID9057632 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057632 Fup 0.454 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057632 Vd NA 0.7365 L/kg 1compartment NA NA Rat Human DTXSID9057632 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057632 TK.Half.Life NA 2.841 hours 1compartment NA NA Rat Human -DTXSID9057632 Css NA 0.2354 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057632 Css NA 1.587 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057632 Css NA 0.2008 mg/L PBTK NA 50% Rat Human -DTXSID9057632 Css NA 0.9636 mg/L PBTK NA 95% Rat Human -DTXSID9057634 Clint NA 10.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057634 Fup NA 0.0448 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057634 Vd NA 0.2492 L/kg 1compartment NA NA Human Human +DTXSID9057632 TK.Half.Life NA 0.3896 hours 1compartment NA NA Rat Human +DTXSID9057632 Css NA 0.005173 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057632 Css NA 0.03583 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057632 Css NA 0.004025 mg/L PBTK NA 50% Rat Human +DTXSID9057632 Css NA 0.02427 mg/L PBTK NA 95% Rat Human +DTXSID9057634 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057634 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057634 Vd NA 0.4285 L/kg 1compartment NA NA Human Human DTXSID9057634 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057634 TK.Half.Life NA 2.253 hours 1compartment NA NA Human Human -DTXSID9057634 Css NA 1.602 mg/L 3compartmentss NA 50% Human Human -DTXSID9057634 Css NA 11.53 mg/L 3compartmentss NA 95% Human Human -DTXSID9057634 Css NA 0.9615 mg/L PBTK NA 50% Human Human -DTXSID9057634 Css NA 6.815 mg/L PBTK NA 95% Human Human -DTXSID9057634 Clint NA 10.04 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057634 Fup NA 0.0448 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057634 Vd NA 0.2442 L/kg 1compartment NA NA Rat Human +DTXSID9057634 TK.Half.Life NA 0.8388 hours 1compartment NA NA Human Human +DTXSID9057634 Css NA 0.1685 mg/L 3compartmentss NA 50% Human Human +DTXSID9057634 Css NA 1.33 mg/L 3compartmentss NA 95% Human Human +DTXSID9057634 Css NA 0.1124 mg/L PBTK NA 50% Human Human +DTXSID9057634 Css NA 0.8403 mg/L PBTK NA 95% Human Human +DTXSID9057634 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057634 Fup 0.149 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057634 Vd NA 0.4213 L/kg 1compartment NA NA Rat Human DTXSID9057634 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057634 TK.Half.Life NA 1.406 hours 1compartment NA NA Rat Human -DTXSID9057634 Css NA 0.881 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057634 Css NA 4.869 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057634 Css NA 0.4951 mg/L PBTK NA 50% Rat Human -DTXSID9057634 Css NA 2.673 mg/L PBTK NA 95% Rat Human -DTXSID9057636 Clint NA 10.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057636 Fup NA 0.3735 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057636 Vd NA 1.559 L/kg 1compartment NA NA Human Human +DTXSID9057634 TK.Half.Life NA 0.4741 hours 1compartment NA NA Rat Human +DTXSID9057634 Css NA 0.02173 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057634 Css NA 0.1418 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057634 Css NA 0.01426 mg/L PBTK NA 50% Rat Human +DTXSID9057634 Css NA 0.08584 mg/L PBTK NA 95% Rat Human +DTXSID9057636 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057636 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057636 Vd NA 1.194 L/kg 1compartment NA NA Human Human DTXSID9057636 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057636 TK.Half.Life NA 2.811 hours 1compartment NA NA Human Human -DTXSID9057636 Css NA 0.1328 mg/L 3compartmentss NA 50% Human Human -DTXSID9057636 Css NA 0.8759 mg/L 3compartmentss NA 95% Human Human -DTXSID9057636 Css NA 0.1044 mg/L PBTK NA 50% Human Human -DTXSID9057636 Css NA 0.6172 mg/L PBTK NA 95% Human Human -DTXSID9057636 Clint NA 10.02 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057636 Fup NA 0.3735 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057636 Vd NA 1.276 L/kg 1compartment NA NA Rat Human +DTXSID9057636 TK.Half.Life NA 2.662 hours 1compartment NA NA Human Human +DTXSID9057636 Css NA 0.178 mg/L 3compartmentss NA 50% Human Human +DTXSID9057636 Css NA 1.179 mg/L 3compartmentss NA 95% Human Human +DTXSID9057636 Css NA 0.1387 mg/L PBTK NA 50% Human Human +DTXSID9057636 Css NA 0.8131 mg/L PBTK NA 95% Human Human +DTXSID9057636 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057636 Fup 0.375 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057636 Vd NA 1.018 L/kg 1compartment NA NA Rat Human DTXSID9057636 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057636 TK.Half.Life NA 1.139 hours 1compartment NA NA Rat Human -DTXSID9057636 Css NA 0.06958 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057636 Css NA 0.3446 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057636 Css NA 0.05306 mg/L PBTK NA 50% Rat Human -DTXSID9057636 Css NA 0.2354 mg/L PBTK NA 95% Rat Human -DTXSID9057638 Clint NA 12.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057638 Fup NA 0.0917 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057638 Vd NA 2.849 L/kg 1compartment NA NA Human Human -DTXSID9057638 Days.Css NA 3 Days PBTK NA NA Human Human -DTXSID9057638 TK.Half.Life NA 33.7 hours 1compartment NA NA Human Human -DTXSID9057638 Css NA 1.464 mg/L 3compartmentss NA 50% Human Human -DTXSID9057638 Css NA 9.151 mg/L 3compartmentss NA 95% Human Human -DTXSID9057638 Css NA 1.019 mg/L PBTK NA 50% Human Human -DTXSID9057638 Css NA 6.135 mg/L PBTK NA 95% Human Human -DTXSID9057638 Clint NA 12.34 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057638 Fup NA 0.0917 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057638 Vd NA 2.142 L/kg 1compartment NA NA Rat Human -DTXSID9057638 Days.Css NA 2 Days PBTK NA NA Rat Human -DTXSID9057638 TK.Half.Life NA 6.436 hours 1compartment NA NA Rat Human -DTXSID9057638 Css NA 0.8024 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057638 Css NA 3.755 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057638 Css NA 0.5311 mg/L PBTK NA 50% Rat Human -DTXSID9057638 Css NA 2.409 mg/L PBTK NA 95% Rat Human -DTXSID9057680 Clint NA 79.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057680 Fup NA 0.3376 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057680 Vd NA 1.298 L/kg 1compartment NA NA Human Human +DTXSID9057636 TK.Half.Life NA 1.203 hours 1compartment NA NA Rat Human +DTXSID9057636 Css NA 0.02082 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057636 Css NA 0.1023 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057636 Css NA 0.01625 mg/L PBTK NA 50% Rat Human +DTXSID9057636 Css NA 0.06783 mg/L PBTK NA 95% Rat Human +DTXSID9057680 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057680 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057680 Vd NA 1.297 L/kg 1compartment NA NA Human Human DTXSID9057680 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057680 TK.Half.Life NA 1.115 hours 1compartment NA NA Human Human -DTXSID9057680 Css NA 0.01892 mg/L 3compartmentss NA 50% Human Human -DTXSID9057680 Css NA 0.1379 mg/L 3compartmentss NA 95% Human Human -DTXSID9057680 Css NA 0.01448 mg/L PBTK NA 50% Human Human -DTXSID9057680 Css NA 0.09578 mg/L PBTK NA 95% Human Human -DTXSID9057680 Clint NA 79.31 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057680 Fup NA 0.3376 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057680 Vd NA 1.081 L/kg 1compartment NA NA Rat Human +DTXSID9057680 TK.Half.Life NA 4.569 hours 1compartment NA NA Human Human +DTXSID9057680 Css NA 0.3408 mg/L 3compartmentss NA 50% Human Human +DTXSID9057680 Css NA 1.924 mg/L 3compartmentss NA 95% Human Human +DTXSID9057680 Css NA 0.2454 mg/L PBTK NA 50% Human Human +DTXSID9057680 Css NA 1.285 mg/L PBTK NA 95% Human Human +DTXSID9057680 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057680 Fup 0.223 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057680 Vd NA 1.045 L/kg 1compartment NA NA Rat Human DTXSID9057680 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057680 TK.Half.Life NA 0.4289 hours 1compartment NA NA Rat Human -DTXSID9057680 Css NA 0.01021 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057680 Css NA 0.06473 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057680 Css NA 0.007555 mg/L PBTK NA 50% Rat Human -DTXSID9057680 Css NA 0.04358 mg/L PBTK NA 95% Rat Human -DTXSID9057682 Clint NA 9.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057682 Fup NA 0.0979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057682 Vd NA 2.14 L/kg 1compartment NA NA Human Human +DTXSID9057680 TK.Half.Life NA 1.931 hours 1compartment NA NA Rat Human +DTXSID9057680 Css NA 0.04028 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057680 Css NA 0.1712 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057680 Css NA 0.02881 mg/L PBTK NA 50% Rat Human +DTXSID9057680 Css NA 0.1128 mg/L PBTK NA 95% Rat Human +DTXSID9057682 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057682 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057682 Vd NA 2.929 L/kg 1compartment NA NA Human Human DTXSID9057682 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9057682 TK.Half.Life NA 15.06 hours 1compartment NA NA Human Human -DTXSID9057682 Css NA 0.9287 mg/L 3compartmentss NA 50% Human Human -DTXSID9057682 Css NA 5.718 mg/L 3compartmentss NA 95% Human Human -DTXSID9057682 Css NA 0.6311 mg/L PBTK NA 50% Human Human -DTXSID9057682 Css NA 3.719 mg/L PBTK NA 95% Human Human -DTXSID9057682 Clint NA 9.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057682 Fup NA 0.0979 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057682 Vd NA 1.621 L/kg 1compartment NA NA Rat Human -DTXSID9057682 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057682 TK.Half.Life NA 4.627 hours 1compartment NA NA Rat Human -DTXSID9057682 Css NA 0.4936 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057682 Css NA 2.366 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057682 Css NA 0.3191 mg/L PBTK NA 50% Rat Human -DTXSID9057682 Css NA 1.447 mg/L PBTK NA 95% Rat Human -DTXSID9057684 Clint NA 0.5139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057684 Fup NA 0.2759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057684 Vd NA 0.3978 L/kg 1compartment NA NA Human Human +DTXSID9057682 TK.Half.Life NA 20.84 hours 1compartment NA NA Human Human +DTXSID9057682 Css NA 0.7922 mg/L 3compartmentss NA 50% Human Human +DTXSID9057682 Css NA 5.037 mg/L 3compartmentss NA 95% Human Human +DTXSID9057682 Css NA 0.5529 mg/L PBTK NA 50% Human Human +DTXSID9057682 Css NA 3.369 mg/L PBTK NA 95% Human Human +DTXSID9057682 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057682 Fup 0.117 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057682 Vd NA 2.205 L/kg 1compartment NA NA Rat Human +DTXSID9057682 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9057682 TK.Half.Life NA 3.903 hours 1compartment NA NA Rat Human +DTXSID9057682 Css NA 0.1023 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057682 Css NA 0.5411 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057682 Css NA 0.07088 mg/L PBTK NA 50% Rat Human +DTXSID9057682 Css NA 0.3682 mg/L PBTK NA 95% Rat Human +DTXSID9057684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057684 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057684 Vd NA 0.5404 L/kg 1compartment NA NA Human Human DTXSID9057684 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057684 TK.Half.Life NA 5.119 hours 1compartment NA NA Human Human -DTXSID9057684 Css NA 1.543 mg/L 3compartmentss NA 50% Human Human -DTXSID9057684 Css NA 6.177 mg/L 3compartmentss NA 95% Human Human -DTXSID9057684 Css NA 1.031 mg/L PBTK NA 50% Human Human -DTXSID9057684 Css NA 3.773 mg/L PBTK NA 95% Human Human -DTXSID9057684 Clint NA 0.5139 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057684 Fup NA 0.2759 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057684 Vd NA 0.3926 L/kg 1compartment NA NA Rat Human +DTXSID9057684 TK.Half.Life NA 0.6217 hours 1compartment NA NA Human Human +DTXSID9057684 Css NA 0.05065 mg/L 3compartmentss NA 50% Human Human +DTXSID9057684 Css NA 0.4201 mg/L 3compartmentss NA 95% Human Human +DTXSID9057684 Css NA 0.03618 mg/L PBTK NA 50% Human Human +DTXSID9057684 Css NA 0.2838 mg/L PBTK NA 95% Human Human +DTXSID9057684 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057684 Fup 0.402 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057684 Vd NA 0.5218 L/kg 1compartment NA NA Rat Human DTXSID9057684 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057684 TK.Half.Life NA 2.232 hours 1compartment NA NA Rat Human -DTXSID9057684 Css NA 0.5658 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057684 Css NA 1.9 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057684 Css NA 0.3577 mg/L PBTK NA 50% Rat Human -DTXSID9057684 Css NA 1.086 mg/L PBTK NA 95% Rat Human +DTXSID9057684 TK.Half.Life NA 0.3072 hours 1compartment NA NA Rat Human +DTXSID9057684 Css NA 0.006268 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057684 Css NA 0.03956 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057684 Css NA 0.004452 mg/L PBTK NA 50% Rat Human +DTXSID9057684 Css NA 0.02524 mg/L PBTK NA 95% Rat Human DTXSID9057686 Clint NA 0.06432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9057686 Fup NA 0.6752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057686 Vd NA 0.6029 L/kg 1compartment NA NA Human Human +DTXSID9057686 Vd NA 0.6244 L/kg 1compartment NA NA Human Human DTXSID9057686 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057686 TK.Half.Life NA 5.078 hours 1compartment NA NA Human Human -DTXSID9057686 Css NA 0.9805 mg/L 3compartmentss NA 50% Human Human -DTXSID9057686 Css NA 6.339 mg/L 3compartmentss NA 95% Human Human -DTXSID9057686 Css NA 0.7761 mg/L PBTK NA 50% Human Human -DTXSID9057686 Css NA 4.039 mg/L PBTK NA 95% Human Human +DTXSID9057686 TK.Half.Life NA 5.316 hours 1compartment NA NA Human Human +DTXSID9057686 Css NA 0.8317 mg/L 3compartmentss NA 50% Human Human +DTXSID9057686 Css NA 5.524 mg/L 3compartmentss NA 95% Human Human +DTXSID9057686 Css NA 0.661 mg/L PBTK NA 50% Human Human +DTXSID9057686 Css NA 3.476 mg/L PBTK NA 95% Human Human DTXSID9057686 Clint NA 0.06432 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9057686 Fup NA 0.6752 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057686 Vd NA 0.6341 L/kg 1compartment NA NA Rat Human +DTXSID9057686 Vd NA 0.6531 L/kg 1compartment NA NA Rat Human DTXSID9057686 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057686 TK.Half.Life NA 1.941 hours 1compartment NA NA Rat Human -DTXSID9057686 Css NA 0.2766 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057686 Css NA 1.833 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057686 Css NA 0.2102 mg/L PBTK NA 50% Rat Human -DTXSID9057686 Css NA 1.065 mg/L PBTK NA 95% Rat Human +DTXSID9057686 TK.Half.Life NA 2.009 hours 1compartment NA NA Rat Human +DTXSID9057686 Css NA 0.01734 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057686 Css NA 0.1423 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057686 Css NA 0.01327 mg/L PBTK NA 50% Rat Human +DTXSID9057686 Css NA 0.0893 mg/L PBTK NA 95% Rat Human +DTXSID9057688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057688 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057688 Vd NA 2.296 L/kg 1compartment NA NA Human Human +DTXSID9057688 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9057688 TK.Half.Life NA 24.79 hours 1compartment NA NA Human Human +DTXSID9057688 Css NA 1.543 mg/L 3compartmentss NA 50% Human Human +DTXSID9057688 Css NA 11.67 mg/L 3compartmentss NA 95% Human Human +DTXSID9057688 Css NA 1.011 mg/L PBTK NA 50% Human Human +DTXSID9057688 Css NA 7.348 mg/L PBTK NA 95% Human Human +DTXSID9057688 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057688 Fup 0.0215 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057688 Vd NA 1.711 L/kg 1compartment NA NA Rat Human +DTXSID9057688 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID9057688 TK.Half.Life NA 6.925 hours 1compartment NA NA Rat Human +DTXSID9057688 Css NA 0.1956 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057688 Css NA 1.262 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057688 Css NA 0.1252 mg/L PBTK NA 50% Rat Human +DTXSID9057688 Css NA 0.7724 mg/L PBTK NA 95% Rat Human DTXSID9057711 Clint NA 10.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human DTXSID9057711 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057711 Vd NA 0.2026 L/kg 1compartment NA NA Human Human +DTXSID9057711 Vd NA 0.1822 L/kg 1compartment NA NA Human Human DTXSID9057711 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057711 TK.Half.Life NA 6.89 hours 1compartment NA NA Human Human -DTXSID9057711 Css NA 6.361 mg/L 3compartmentss NA 50% Human Human -DTXSID9057711 Css NA 59.22 mg/L 3compartmentss NA 95% Human Human -DTXSID9057711 Css NA 3.724 mg/L PBTK NA 50% Human Human -DTXSID9057711 Css NA 34.53 mg/L PBTK NA 95% Human Human +DTXSID9057711 TK.Half.Life NA 6.284 hours 1compartment NA NA Human Human +DTXSID9057711 Css NA 6.306 mg/L 3compartmentss NA 50% Human Human +DTXSID9057711 Css NA 58.65 mg/L 3compartmentss NA 95% Human Human +DTXSID9057711 Css NA 3.691 mg/L PBTK NA 50% Human Human +DTXSID9057711 Css NA 34.19 mg/L PBTK NA 95% Human Human DTXSID9057711 Clint NA 10.84 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human DTXSID9057711 Fup NA 0.0101 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057711 Vd NA 0.1918 L/kg 1compartment NA NA Rat Human +DTXSID9057711 Vd NA 0.1775 L/kg 1compartment NA NA Rat Human DTXSID9057711 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057711 TK.Half.Life NA 4.292 hours 1compartment NA NA Rat Human -DTXSID9057711 Css NA 3.506 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057711 Css NA 26.21 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057711 Css NA 1.915 mg/L PBTK NA 50% Rat Human -DTXSID9057711 Css NA 14.21 mg/L PBTK NA 95% Rat Human -DTXSID9057713 Clint NA 3.837 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057713 Fup NA 0.1304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057713 Vd NA 0.6567 L/kg 1compartment NA NA Human Human +DTXSID9057711 TK.Half.Life NA 4.032 hours 1compartment NA NA Rat Human +DTXSID9057711 Css NA 0.8069 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057711 Css NA 5.896 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057711 Css NA 0.4556 mg/L PBTK NA 50% Rat Human +DTXSID9057711 Css NA 3.298 mg/L PBTK NA 95% Rat Human +DTXSID9057713 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057713 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057713 Vd NA 1.035 L/kg 1compartment NA NA Human Human DTXSID9057713 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057713 TK.Half.Life NA 4.864 hours 1compartment NA NA Human Human -DTXSID9057713 Css NA 1.05 mg/L 3compartmentss NA 50% Human Human -DTXSID9057713 Css NA 6.722 mg/L 3compartmentss NA 95% Human Human -DTXSID9057713 Css NA 0.6789 mg/L PBTK NA 50% Human Human -DTXSID9057713 Css NA 4.085 mg/L PBTK NA 95% Human Human -DTXSID9057713 Clint NA 3.837 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057713 Fup NA 0.1304 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057713 Vd NA 0.5579 L/kg 1compartment NA NA Rat Human +DTXSID9057713 TK.Half.Life NA 2.531 hours 1compartment NA NA Human Human +DTXSID9057713 Css NA 0.2088 mg/L 3compartmentss NA 50% Human Human +DTXSID9057713 Css NA 1.253 mg/L 3compartmentss NA 95% Human Human +DTXSID9057713 Css NA 0.1569 mg/L PBTK NA 50% Human Human +DTXSID9057713 Css NA 0.8601 mg/L PBTK NA 95% Human Human +DTXSID9057713 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057713 Fup 0.326 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057713 Vd NA 0.8913 L/kg 1compartment NA NA Rat Human DTXSID9057713 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057713 TK.Half.Life NA 2.375 hours 1compartment NA NA Rat Human -DTXSID9057713 Css NA 0.5305 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057713 Css NA 2.479 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057713 Css NA 0.3258 mg/L PBTK NA 50% Rat Human -DTXSID9057713 Css NA 1.408 mg/L PBTK NA 95% Rat Human -DTXSID9057715 Clint NA 54.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057715 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057715 Vd NA 1.463 L/kg 1compartment NA NA Human Human +DTXSID9057713 TK.Half.Life NA 1.185 hours 1compartment NA NA Rat Human +DTXSID9057713 Css NA 0.02425 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057713 Css NA 0.1122 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057713 Css NA 0.01824 mg/L PBTK NA 50% Rat Human +DTXSID9057713 Css NA 0.07436 mg/L PBTK NA 95% Rat Human +DTXSID9057715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057715 Fup 0.0819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057715 Vd NA 2.223 L/kg 1compartment NA NA Human Human DTXSID9057715 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057715 TK.Half.Life NA 5.026 hours 1compartment NA NA Human Human -DTXSID9057715 Css NA 0.4435 mg/L 3compartmentss NA 50% Human Human -DTXSID9057715 Css NA 4.378 mg/L 3compartmentss NA 95% Human Human -DTXSID9057715 Css NA 0.281 mg/L PBTK NA 50% Human Human -DTXSID9057715 Css NA 2.606 mg/L PBTK NA 95% Human Human -DTXSID9057715 Clint NA 54.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057715 Fup NA 0.027 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057715 Vd NA 1.125 L/kg 1compartment NA NA Rat Human +DTXSID9057715 TK.Half.Life NA 8.58 hours 1compartment NA NA Human Human +DTXSID9057715 Css NA 0.4364 mg/L 3compartmentss NA 50% Human Human +DTXSID9057715 Css NA 3.161 mg/L 3compartmentss NA 95% Human Human +DTXSID9057715 Css NA 0.3015 mg/L PBTK NA 50% Human Human +DTXSID9057715 Css NA 2.032 mg/L PBTK NA 95% Human Human +DTXSID9057715 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057715 Fup 0.0819 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057715 Vd NA 1.737 L/kg 1compartment NA NA Rat Human DTXSID9057715 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057715 TK.Half.Life NA 2.041 hours 1compartment NA NA Rat Human -DTXSID9057715 Css NA 0.2545 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057715 Css NA 1.904 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057715 Css NA 0.1516 mg/L PBTK NA 50% Rat Human -DTXSID9057715 Css NA 1.105 mg/L PBTK NA 95% Rat Human -DTXSID9057717 Clint NA 2.418 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057717 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057717 Vd NA 1.862 L/kg 1compartment NA NA Human Human -DTXSID9057717 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057717 TK.Half.Life NA 2.947 hours 1compartment NA NA Human Human -DTXSID9057717 Css NA 0.1441 mg/L 3compartmentss NA 50% Human Human -DTXSID9057717 Css NA 1.236 mg/L 3compartmentss NA 95% Human Human -DTXSID9057717 Css NA 0.1442 mg/L PBTK NA 50% Human Human -DTXSID9057717 Css NA 0.9134 mg/L PBTK NA 95% Human Human -DTXSID9057717 Clint NA 2.418 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057717 Fup NA 1 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057717 Vd NA 1.906 L/kg 1compartment NA NA Rat Human +DTXSID9057715 TK.Half.Life NA 2.886 hours 1compartment NA NA Rat Human +DTXSID9057715 Css NA 0.0563 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057715 Css NA 0.3122 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057715 Css NA 0.03856 mg/L PBTK NA 50% Rat Human +DTXSID9057715 Css NA 0.2005 mg/L PBTK NA 95% Rat Human +DTXSID9057717 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057717 Fup 0.748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057717 Vd NA 2.281 L/kg 1compartment NA NA Human Human +DTXSID9057717 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID9057717 TK.Half.Life NA 19.74 hours 1compartment NA NA Human Human +DTXSID9057717 Css NA 0.6875 mg/L 3compartmentss NA 50% Human Human +DTXSID9057717 Css NA 5.27 mg/L 3compartmentss NA 95% Human Human +DTXSID9057717 Css NA 0.7334 mg/L PBTK NA 50% Human Human +DTXSID9057717 Css NA 3.625 mg/L PBTK NA 95% Human Human +DTXSID9057717 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057717 Fup 0.748 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057717 Vd NA 2.316 L/kg 1compartment NA NA Rat Human DTXSID9057717 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057717 TK.Half.Life NA 1.591 hours 1compartment NA NA Rat Human -DTXSID9057717 Css NA 0.06024 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057717 Css NA 0.4404 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057717 Css NA 0.06139 mg/L PBTK NA 50% Rat Human -DTXSID9057717 Css NA 0.2931 mg/L PBTK NA 95% Rat Human -DTXSID9057719 Clint NA 13.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057719 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057719 Vd NA 2.484 L/kg 1compartment NA NA Human Human -DTXSID9057719 Days.Css NA 13 Days PBTK NA NA Human Human -DTXSID9057719 TK.Half.Life NA 83.3 hours 1compartment NA NA Human Human -DTXSID9057719 Css NA 5.076 mg/L 3compartmentss NA 50% Human Human -DTXSID9057719 Css NA 36.58 mg/L 3compartmentss NA 95% Human Human -DTXSID9057719 Css NA 3.319 mg/L PBTK NA 50% Human Human -DTXSID9057719 Css NA 23.36 mg/L PBTK NA 95% Human Human -DTXSID9057719 Clint NA 13.41 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057719 Fup NA 0.0064 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057719 Vd NA 1.863 L/kg 1compartment NA NA Rat Human -DTXSID9057719 Days.Css NA 7 Days PBTK NA NA Rat Human -DTXSID9057719 TK.Half.Life NA 21.11 hours 1compartment NA NA Rat Human -DTXSID9057719 Css NA 2.812 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057719 Css NA 17.61 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057719 Css NA 1.762 mg/L PBTK NA 50% Rat Human -DTXSID9057719 Css NA 10.56 mg/L PBTK NA 95% Rat Human -DTXSID9057763 Clint NA 108 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057763 Fup NA 0.3078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057763 Vd NA 4.048 L/kg 1compartment NA NA Human Human +DTXSID9057717 TK.Half.Life NA 6.829 hours 1compartment NA NA Rat Human +DTXSID9057717 Css NA 0.01739 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057717 Css NA 0.1587 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057717 Css NA 0.01822 mg/L PBTK NA 50% Rat Human +DTXSID9057717 Css NA 0.1139 mg/L PBTK NA 95% Rat Human +DTXSID9057719 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057719 Fup 0.0159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057719 Vd NA 2.852 L/kg 1compartment NA NA Human Human +DTXSID9057719 Days.Css NA 6 Days PBTK NA NA Human Human +DTXSID9057719 TK.Half.Life NA 48.78 hours 1compartment NA NA Human Human +DTXSID9057719 Css NA 1.957 mg/L 3compartmentss NA 50% Human Human +DTXSID9057719 Css NA 14.47 mg/L 3compartmentss NA 95% Human Human +DTXSID9057719 Css NA 1.336 mg/L PBTK NA 50% Human Human +DTXSID9057719 Css NA 9.477 mg/L PBTK NA 95% Human Human +DTXSID9057719 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057719 Fup 0.0159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057719 Vd NA 2.15 L/kg 1compartment NA NA Rat Human +DTXSID9057719 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID9057719 TK.Half.Life NA 9.62 hours 1compartment NA NA Rat Human +DTXSID9057719 Css NA 0.1003 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057719 Css NA 0.701 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057719 Css NA 0.06692 mg/L PBTK NA 50% Rat Human +DTXSID9057719 Css NA 0.4454 mg/L PBTK NA 95% Rat Human +DTXSID9057761 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057761 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057761 Vd NA 0.8081 L/kg 1compartment NA NA Human Human +DTXSID9057761 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9057761 TK.Half.Life NA 0.9068 hours 1compartment NA NA Human Human +DTXSID9057761 Css NA 0.0491 mg/L 3compartmentss NA 50% Human Human +DTXSID9057761 Css NA 0.3984 mg/L 3compartmentss NA 95% Human Human +DTXSID9057761 Css NA 0.0373 mg/L PBTK NA 50% Human Human +DTXSID9057761 Css NA 0.2704 mg/L PBTK NA 95% Human Human +DTXSID9057761 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057761 Fup 0.39 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057761 Vd NA 0.8092 L/kg 1compartment NA NA Rat Human +DTXSID9057761 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9057761 TK.Half.Life NA 0.4709 hours 1compartment NA NA Rat Human +DTXSID9057761 Css NA 0.006074 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057761 Css NA 0.03734 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057761 Css NA 0.004596 mg/L PBTK NA 50% Rat Human +DTXSID9057761 Css NA 0.02535 mg/L PBTK NA 95% Rat Human +DTXSID9057763 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057763 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057763 Vd NA 4.216 L/kg 1compartment NA NA Human Human DTXSID9057763 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057763 TK.Half.Life NA 2.143 hours 1compartment NA NA Human Human -DTXSID9057763 Css NA 0.007664 mg/L 3compartmentss NA 50% Human Human -DTXSID9057763 Css NA 0.06652 mg/L 3compartmentss NA 95% Human Human -DTXSID9057763 Css NA 0.009339 mg/L PBTK NA 50% Human Human -DTXSID9057763 Css NA 0.06674 mg/L PBTK NA 95% Human Human -DTXSID9057763 Clint NA 108 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057763 Fup NA 0.3078 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057763 Vd NA 4.064 L/kg 1compartment NA NA Rat Human +DTXSID9057763 TK.Half.Life NA 8.154 hours 1compartment NA NA Human Human +DTXSID9057763 Css NA 0.1052 mg/L 3compartmentss NA 50% Human Human +DTXSID9057763 Css NA 0.8442 mg/L 3compartmentss NA 95% Human Human +DTXSID9057763 Css NA 0.133 mg/L PBTK NA 50% Human Human +DTXSID9057763 Css NA 0.8002 mg/L PBTK NA 95% Human Human +DTXSID9057763 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057763 Fup 0.33 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057763 Vd NA 4.239 L/kg 1compartment NA NA Rat Human DTXSID9057763 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057763 TK.Half.Life NA 1.017 hours 1compartment NA NA Rat Human -DTXSID9057763 Css NA 0.003982 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057763 Css NA 0.03017 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057763 Css NA 0.00494 mg/L PBTK NA 50% Rat Human -DTXSID9057763 Css NA 0.02908 mg/L PBTK NA 95% Rat Human -DTXSID9057765 Clint NA 13.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057765 Fup NA 0.0779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057765 Vd NA 0.7558 L/kg 1compartment NA NA Human Human +DTXSID9057763 TK.Half.Life NA 4.56 hours 1compartment NA NA Rat Human +DTXSID9057763 Css NA 0.01192 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057763 Css NA 0.06989 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057763 Css NA 0.01599 mg/L PBTK NA 50% Rat Human +DTXSID9057763 Css NA 0.06671 mg/L PBTK NA 95% Rat Human +DTXSID9057765 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057765 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057765 Vd NA 0.9977 L/kg 1compartment NA NA Human Human DTXSID9057765 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057765 TK.Half.Life NA 3.324 hours 1compartment NA NA Human Human -DTXSID9057765 Css NA 0.6129 mg/L 3compartmentss NA 50% Human Human -DTXSID9057765 Css NA 4.57 mg/L 3compartmentss NA 95% Human Human -DTXSID9057765 Css NA 0.3866 mg/L PBTK NA 50% Human Human -DTXSID9057765 Css NA 2.746 mg/L PBTK NA 95% Human Human -DTXSID9057765 Clint NA 13.29 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057765 Fup NA 0.0779 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057765 Vd NA 0.608 L/kg 1compartment NA NA Rat Human +DTXSID9057765 TK.Half.Life NA 2.099 hours 1compartment NA NA Human Human +DTXSID9057765 Css NA 0.1665 mg/L 3compartmentss NA 50% Human Human +DTXSID9057765 Css NA 1.097 mg/L 3compartmentss NA 95% Human Human +DTXSID9057765 Css NA 0.1293 mg/L PBTK NA 50% Human Human +DTXSID9057765 Css NA 0.7641 mg/L PBTK NA 95% Human Human +DTXSID9057765 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057765 Fup 0.388 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057765 Vd NA 0.8921 L/kg 1compartment NA NA Rat Human DTXSID9057765 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057765 TK.Half.Life NA 1.59 hours 1compartment NA NA Rat Human -DTXSID9057765 Css NA 0.3378 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057765 Css NA 1.915 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057765 Css NA 0.2 mg/L PBTK NA 50% Rat Human -DTXSID9057765 Css NA 1.084 mg/L PBTK NA 95% Rat Human -DTXSID9057767 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057767 Fup NA 0.122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057767 Vd NA 0.2822 L/kg 1compartment NA NA Human Human +DTXSID9057765 TK.Half.Life NA 1.023 hours 1compartment NA NA Rat Human +DTXSID9057765 Css NA 0.01896 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057765 Css NA 0.09809 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057765 Css NA 0.01472 mg/L PBTK NA 50% Rat Human +DTXSID9057765 Css NA 0.0653 mg/L PBTK NA 95% Rat Human +DTXSID9057767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057767 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057767 Vd NA 0.348 L/kg 1compartment NA NA Human Human DTXSID9057767 Days.Css NA 1 Days PBTK NA NA Human Human -DTXSID9057767 TK.Half.Life NA 14.97 hours 1compartment NA NA Human Human -DTXSID9057767 Css NA 7.982 mg/L 3compartmentss NA 50% Human Human -DTXSID9057767 Css NA 38.17 mg/L 3compartmentss NA 95% Human Human -DTXSID9057767 Css NA 4.983 mg/L PBTK NA 50% Human Human -DTXSID9057767 Css NA 22.48 mg/L PBTK NA 95% Human Human -DTXSID9057767 Clint NA 0 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057767 Fup NA 0.122 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057767 Vd NA 0.287 L/kg 1compartment NA NA Rat Human +DTXSID9057767 TK.Half.Life NA 13.73 hours 1compartment NA NA Human Human +DTXSID9057767 Css NA 2.795 mg/L 3compartmentss NA 50% Human Human +DTXSID9057767 Css NA 12.2 mg/L 3compartmentss NA 95% Human Human +DTXSID9057767 Css NA 1.806 mg/L PBTK NA 50% Human Human +DTXSID9057767 Css NA 7.339 mg/L PBTK NA 95% Human Human +DTXSID9057767 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057767 Fup 0.164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057767 Vd NA 0.3515 L/kg 1compartment NA NA Rat Human DTXSID9057767 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057767 TK.Half.Life NA 5.188 hours 1compartment NA NA Rat Human -DTXSID9057767 Css NA 2.299 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057767 Css NA 8.725 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057767 Css NA 1.334 mg/L PBTK NA 50% Rat Human -DTXSID9057767 Css NA 4.809 mg/L PBTK NA 95% Rat Human -DTXSID9057769 Clint NA 17.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057769 Fup NA 0.1753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057769 Vd NA 1.585 L/kg 1compartment NA NA Human Human +DTXSID9057767 TK.Half.Life NA 4.725 hours 1compartment NA NA Rat Human +DTXSID9057767 Css NA 0.0152 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057767 Css NA 0.06487 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057767 Css NA 0.00929 mg/L PBTK NA 50% Rat Human +DTXSID9057767 Css NA 0.0374 mg/L PBTK NA 95% Rat Human +DTXSID9057769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057769 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057769 Vd NA 1.183 L/kg 1compartment NA NA Human Human DTXSID9057769 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057769 TK.Half.Life NA 3.551 hours 1compartment NA NA Human Human -DTXSID9057769 Css NA 0.1908 mg/L 3compartmentss NA 50% Human Human -DTXSID9057769 Css NA 1.256 mg/L 3compartmentss NA 95% Human Human -DTXSID9057769 Css NA 0.1348 mg/L PBTK NA 50% Human Human -DTXSID9057769 Css NA 0.8318 mg/L PBTK NA 95% Human Human -DTXSID9057769 Clint NA 17.69 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057769 Fup NA 0.1753 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057769 Vd NA 1.236 L/kg 1compartment NA NA Rat Human +DTXSID9057769 TK.Half.Life NA 2.27 hours 1compartment NA NA Human Human +DTXSID9057769 Css NA 0.1491 mg/L 3compartmentss NA 50% Human Human +DTXSID9057769 Css NA 1.032 mg/L 3compartmentss NA 95% Human Human +DTXSID9057769 Css NA 0.1026 mg/L PBTK NA 50% Human Human +DTXSID9057769 Css NA 0.6579 mg/L PBTK NA 95% Human Human +DTXSID9057769 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057769 Fup 0.165 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057769 Vd NA 0.9438 L/kg 1compartment NA NA Rat Human DTXSID9057769 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057769 TK.Half.Life NA 1.364 hours 1compartment NA NA Rat Human -DTXSID9057769 Css NA 0.1049 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057769 Css NA 0.5122 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057769 Css NA 0.07064 mg/L PBTK NA 50% Rat Human -DTXSID9057769 Css NA 0.3266 mg/L PBTK NA 95% Rat Human -DTXSID9057840 Clint NA 72.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057840 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057840 Vd NA 3.071 L/kg 1compartment NA NA Human Human -DTXSID9057840 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9057840 TK.Half.Life NA 25.83 hours 1compartment NA NA Human Human -DTXSID9057840 Css NA 0.9676 mg/L 3compartmentss NA 50% Human Human -DTXSID9057840 Css NA 6.486 mg/L 3compartmentss NA 95% Human Human -DTXSID9057840 Css NA 0.6678 mg/L PBTK NA 50% Human Human -DTXSID9057840 Css NA 4.291 mg/L PBTK NA 95% Human Human -DTXSID9057840 Clint NA 72.23 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057840 Fup NA 0.014 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057840 Vd NA 2.3 L/kg 1compartment NA NA Rat Human -DTXSID9057840 Days.Css NA 1 Days PBTK NA NA Rat Human -DTXSID9057840 TK.Half.Life NA 4.056 hours 1compartment NA NA Rat Human -DTXSID9057840 Css NA 0.5498 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057840 Css NA 2.968 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057840 Css NA 0.3633 mg/L PBTK NA 50% Rat Human -DTXSID9057840 Css NA 1.877 mg/L PBTK NA 95% Rat Human -DTXSID9057842 Clint NA 2.524 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057842 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057842 Vd NA 0.1943 L/kg 1compartment NA NA Human Human -DTXSID9057842 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9057842 TK.Half.Life NA 16.31 hours 1compartment NA NA Human Human -DTXSID9057842 Css NA 15.14 mg/L 3compartmentss NA 50% Human Human -DTXSID9057842 Css NA 114.6 mg/L 3compartmentss NA 95% Human Human -DTXSID9057842 Css NA 8.944 mg/L PBTK NA 50% Human Human -DTXSID9057842 Css NA 67.48 mg/L PBTK NA 95% Human Human -DTXSID9057842 Clint NA 2.524 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057842 Fup NA 0.015 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057842 Vd NA 0.1904 L/kg 1compartment NA NA Rat Human +DTXSID9057769 TK.Half.Life NA 0.9545 hours 1compartment NA NA Rat Human +DTXSID9057769 Css NA 0.01899 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057769 Css NA 0.1043 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057769 Css NA 0.01288 mg/L PBTK NA 50% Rat Human +DTXSID9057769 Css NA 0.06659 mg/L PBTK NA 95% Rat Human +DTXSID9057840 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057840 Fup 0.00575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057840 Vd NA 2.816 L/kg 1compartment NA NA Human Human +DTXSID9057840 Days.Css NA 10 Days PBTK NA NA Human Human +DTXSID9057840 TK.Half.Life NA 69.41 hours 1compartment NA NA Human Human +DTXSID9057840 Css NA 3.33 mg/L 3compartmentss NA 50% Human Human +DTXSID9057840 Css NA 22.84 mg/L 3compartmentss NA 95% Human Human +DTXSID9057840 Css NA 2.226 mg/L PBTK NA 50% Human Human +DTXSID9057840 Css NA 14.7 mg/L PBTK NA 95% Human Human +DTXSID9057840 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057840 Fup 0.00575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057840 Vd NA 2.102 L/kg 1compartment NA NA Rat Human +DTXSID9057840 Days.Css NA 6 Days PBTK NA NA Rat Human +DTXSID9057840 TK.Half.Life NA 13.2 hours 1compartment NA NA Rat Human +DTXSID9057840 Css NA 0.4283 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057840 Css NA 2.565 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057840 Css NA 0.2842 mg/L PBTK NA 50% Rat Human +DTXSID9057840 Css NA 1.659 mg/L PBTK NA 95% Rat Human +DTXSID9057842 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057842 Fup 0.0593 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057842 Vd NA 0.2808 L/kg 1compartment NA NA Human Human +DTXSID9057842 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9057842 TK.Half.Life NA 1.075 hours 1compartment NA NA Human Human +DTXSID9057842 Css NA 0.5156 mg/L 3compartmentss NA 50% Human Human +DTXSID9057842 Css NA 4.23 mg/L 3compartmentss NA 95% Human Human +DTXSID9057842 Css NA 0.3156 mg/L PBTK NA 50% Human Human +DTXSID9057842 Css NA 2.471 mg/L PBTK NA 95% Human Human +DTXSID9057842 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057842 Fup 0.0593 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057842 Vd NA 0.2742 L/kg 1compartment NA NA Rat Human DTXSID9057842 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057842 TK.Half.Life NA 9.282 hours 1compartment NA NA Rat Human -DTXSID9057842 Css NA 7.377 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057842 Css NA 46.14 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057842 Css NA 4.05 mg/L PBTK NA 50% Rat Human -DTXSID9057842 Css NA 24.98 mg/L PBTK NA 95% Rat Human -DTXSID9057844 Clint NA 181.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057844 Fup NA 0.005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057844 Vd NA 84.13 L/kg 1compartment NA NA Human Human -DTXSID9057844 Days.Css NA 61 Days PBTK NA NA Human Human -DTXSID9057844 TK.Half.Life NA 305.9 hours 1compartment NA NA Human Human -DTXSID9057844 Css NA 0.03043 mg/L 3compartmentss NA 50% Human Human -DTXSID9057844 Css NA 0.1864 mg/L 3compartmentss NA 95% Human Human -DTXSID9057844 Css NA 0.3016 mg/L PBTK NA 50% Human Human -DTXSID9057844 Css NA 1.696 mg/L PBTK NA 95% Human Human -DTXSID9057844 Clint NA 181.3 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057844 Fup NA 0.005 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057844 Vd NA 72.3 L/kg 1compartment NA NA Rat Human -DTXSID9057844 Days.Css NA 42 Days PBTK NA NA Rat Human -DTXSID9057844 TK.Half.Life NA 48.74 hours 1compartment NA NA Rat Human -DTXSID9057844 Css NA 0.01561 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057844 Css NA 0.06589 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057844 Css NA 0.1626 mg/L PBTK NA 50% Rat Human -DTXSID9057844 Css NA 0.6959 mg/L PBTK NA 95% Rat Human -DTXSID9057846 Clint NA 1.156 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057846 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057846 Vd NA 0.3012 L/kg 1compartment NA NA Human Human -DTXSID9057846 Days.Css NA 2 Days PBTK NA NA Human Human -DTXSID9057846 TK.Half.Life NA 18.69 hours 1compartment NA NA Human Human -DTXSID9057846 Css NA 11.14 mg/L 3compartmentss NA 50% Human Human -DTXSID9057846 Css NA 58.38 mg/L 3compartmentss NA 95% Human Human -DTXSID9057846 Css NA 6.772 mg/L PBTK NA 50% Human Human -DTXSID9057846 Css NA 34.45 mg/L PBTK NA 95% Human Human -DTXSID9057846 Clint NA 1.156 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057846 Fup NA 0.036 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057846 Vd NA 0.2939 L/kg 1compartment NA NA Rat Human +DTXSID9057842 TK.Half.Life NA 0.6521 hours 1compartment NA NA Rat Human +DTXSID9057842 Css NA 0.06695 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057842 Css NA 0.4376 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057842 Css NA 0.03976 mg/L PBTK NA 50% Rat Human +DTXSID9057842 Css NA 0.2508 mg/L PBTK NA 95% Rat Human +DTXSID9057844 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057844 Fup 0.00575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057844 Vd NA 22.57 L/kg 1compartment NA NA Human Human +DTXSID9057844 Days.Css NA 159 Days PBTK NA NA Human Human +DTXSID9057844 TK.Half.Life NA 678.2 hours 1compartment NA NA Human Human +DTXSID9057844 Css NA 1.019 mg/L 3compartmentss NA 50% Human Human +DTXSID9057844 Css NA 6.317 mg/L 3compartmentss NA 95% Human Human +DTXSID9057844 Css NA 2.419 mg/L PBTK NA 50% Human Human +DTXSID9057844 Css NA 13.89 mg/L PBTK NA 95% Human Human +DTXSID9057844 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057844 Fup 0.00575 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057844 Vd NA 18.43 L/kg 1compartment NA NA Rat Human +DTXSID9057844 Days.Css NA 97 Days PBTK NA NA Rat Human +DTXSID9057844 TK.Half.Life NA 100.6 hours 1compartment NA NA Rat Human +DTXSID9057844 Css NA 0.1248 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057844 Css NA 0.5849 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057844 Css NA 0.316 mg/L PBTK NA 50% Rat Human +DTXSID9057844 Css NA 1.617 mg/L PBTK NA 95% Rat Human +DTXSID9057846 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057846 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057846 Vd NA 0.5027 L/kg 1compartment NA NA Human Human +DTXSID9057846 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9057846 TK.Half.Life NA 3.022 hours 1compartment NA NA Human Human +DTXSID9057846 Css NA 0.8019 mg/L 3compartmentss NA 50% Human Human +DTXSID9057846 Css NA 5.708 mg/L 3compartmentss NA 95% Human Human +DTXSID9057846 Css NA 0.5387 mg/L PBTK NA 50% Human Human +DTXSID9057846 Css NA 3.611 mg/L PBTK NA 95% Human Human +DTXSID9057846 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057846 Fup 0.107 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057846 Vd NA 0.4944 L/kg 1compartment NA NA Rat Human DTXSID9057846 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057846 TK.Half.Life NA 9.353 hours 1compartment NA NA Rat Human -DTXSID9057846 Css NA 4.787 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057846 Css NA 20.22 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057846 Css NA 2.724 mg/L PBTK NA 50% Rat Human -DTXSID9057846 Css NA 11.07 mg/L PBTK NA 95% Rat Human -DTXSID9057848 Clint NA 38.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057848 Fup NA 0.2277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057848 Vd NA 2.73 L/kg 1compartment NA NA Human Human +DTXSID9057846 TK.Half.Life NA 1.815 hours 1compartment NA NA Rat Human +DTXSID9057846 Css NA 0.09824 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057846 Css NA 0.5154 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057846 Css NA 0.06446 mg/L PBTK NA 50% Rat Human +DTXSID9057846 Css NA 0.3078 mg/L PBTK NA 95% Rat Human +DTXSID9057848 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057848 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057848 Vd NA 1.569 L/kg 1compartment NA NA Human Human DTXSID9057848 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID9057848 TK.Half.Life NA 5.682 hours 1compartment NA NA Human Human -DTXSID9057848 Css NA 0.1609 mg/L 3compartmentss NA 50% Human Human -DTXSID9057848 Css NA 1.046 mg/L 3compartmentss NA 95% Human Human -DTXSID9057848 Css NA 0.117 mg/L PBTK NA 50% Human Human -DTXSID9057848 Css NA 0.7167 mg/L PBTK NA 95% Human Human -DTXSID9057848 Clint NA 38.63 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057848 Fup NA 0.2277 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057848 Vd NA 2.073 L/kg 1compartment NA NA Rat Human +DTXSID9057848 TK.Half.Life NA 8.386 hours 1compartment NA NA Human Human +DTXSID9057848 Css NA 0.632 mg/L 3compartmentss NA 50% Human Human +DTXSID9057848 Css NA 4.026 mg/L 3compartmentss NA 95% Human Human +DTXSID9057848 Css NA 0.4356 mg/L PBTK NA 50% Human Human +DTXSID9057848 Css NA 2.554 mg/L PBTK NA 95% Human Human +DTXSID9057848 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057848 Fup 0.15 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057848 Vd NA 1.217 L/kg 1compartment NA NA Rat Human DTXSID9057848 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057848 TK.Half.Life NA 1.461 hours 1compartment NA NA Rat Human -DTXSID9057848 Css NA 0.08974 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057848 Css NA 0.4447 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057848 Css NA 0.06224 mg/L PBTK NA 50% Rat Human -DTXSID9057848 Css NA 0.302 mg/L PBTK NA 95% Rat Human -DTXSID9057898 Clint NA 0.003329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057898 Fup NA 0.0653 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human -DTXSID9057898 Vd NA 0.2732 L/kg 1compartment NA NA Human Human -DTXSID9057898 Days.Css NA 4 Days PBTK NA NA Human Human -DTXSID9057898 TK.Half.Life NA 27 hours 1compartment NA NA Human Human -DTXSID9057898 Css NA 15.81 mg/L 3compartmentss NA 50% Human Human -DTXSID9057898 Css NA 68.03 mg/L 3compartmentss NA 95% Human Human -DTXSID9057898 Css NA 9.554 mg/L PBTK NA 50% Human Human -DTXSID9057898 Css NA 39.47 mg/L PBTK NA 95% Human Human -DTXSID9057898 Clint NA 0.003329 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057898 Fup NA 0.0653 ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human -DTXSID9057898 Vd NA 0.2557 L/kg 1compartment NA NA Rat Human +DTXSID9057848 TK.Half.Life NA 3.194 hours 1compartment NA NA Rat Human +DTXSID9057848 Css NA 0.07673 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057848 Css NA 0.3673 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057848 Css NA 0.05214 mg/L PBTK NA 50% Rat Human +DTXSID9057848 Css NA 0.2277 mg/L PBTK NA 95% Rat Human +DTXSID9057894 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057894 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057894 Vd NA 2.848 L/kg 1compartment NA NA Human Human +DTXSID9057894 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9057894 TK.Half.Life NA 3.27 hours 1compartment NA NA Human Human +DTXSID9057894 Css NA 0.06555 mg/L 3compartmentss NA 50% Human Human +DTXSID9057894 Css NA 0.6028 mg/L 3compartmentss NA 95% Human Human +DTXSID9057894 Css NA 0.05396 mg/L PBTK NA 50% Human Human +DTXSID9057894 Css NA 0.4347 mg/L PBTK NA 95% Human Human +DTXSID9057894 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057894 Fup 0.0341 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057894 Vd NA 2.566 L/kg 1compartment NA NA Rat Human +DTXSID9057894 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9057894 TK.Half.Life NA 1.415 hours 1compartment NA NA Rat Human +DTXSID9057894 Css NA 0.008724 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057894 Css NA 0.06316 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057894 Css NA 0.007156 mg/L PBTK NA 50% Rat Human +DTXSID9057894 Css NA 0.04632 mg/L PBTK NA 95% Rat Human +DTXSID9057898 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057898 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9057898 Vd NA 0.4273 L/kg 1compartment NA NA Human Human +DTXSID9057898 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9057898 TK.Half.Life NA 0.8166 hours 1compartment NA NA Human Human +DTXSID9057898 Css NA 0.156 mg/L 3compartmentss NA 50% Human Human +DTXSID9057898 Css NA 1.197 mg/L 3compartmentss NA 95% Human Human +DTXSID9057898 Css NA 0.1011 mg/L PBTK NA 50% Human Human +DTXSID9057898 Css NA 0.7265 mg/L PBTK NA 95% Human Human +DTXSID9057898 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057898 Fup 0.159 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9057898 Vd NA 0.3905 L/kg 1compartment NA NA Rat Human DTXSID9057898 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID9057898 TK.Half.Life NA 8.616 hours 1compartment NA NA Rat Human -DTXSID9057898 Css NA 4.557 mg/L 3compartmentss NA 50% Rat Human -DTXSID9057898 Css NA 16.12 mg/L 3compartmentss NA 95% Rat Human -DTXSID9057898 Css NA 2.568 mg/L PBTK NA 50% Rat Human -DTXSID9057898 Css NA 8.818 mg/L PBTK NA 95% Rat Human -DTXSID9058654 Clint NA 161.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9057898 TK.Half.Life NA 0.4211 hours 1compartment NA NA Rat Human +DTXSID9057898 Css NA 0.02024 mg/L 3compartmentss NA 50% Rat Human +DTXSID9057898 Css NA 0.1203 mg/L 3compartmentss NA 95% Rat Human +DTXSID9057898 Css NA 0.01278 mg/L PBTK NA 50% Rat Human +DTXSID9057898 Css NA 0.07211 mg/L PBTK NA 95% Rat Human +DTXSID9058654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID9058654 Fup 2.4e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Human Human -DTXSID9058654 Vd NA 10.19 L/kg 1compartment NA NA Human Human -DTXSID9058654 Days.Css NA 7 Days PBTK NA NA Human Human -DTXSID9058654 TK.Half.Life NA 60.22 hours 1compartment NA NA Human Human -DTXSID9058654 Css NA 0.3274 mg/L 3compartmentss NA 50% Human Human -DTXSID9058654 Css NA 1.824 mg/L 3compartmentss NA 95% Human Human -DTXSID9058654 Css NA 0.417 mg/L PBTK NA 50% Human Human -DTXSID9058654 Css NA 2.289 mg/L PBTK NA 95% Human Human -DTXSID9058654 Clint NA 161.6 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID9058654 Vd NA 4.384 L/kg 1compartment NA NA Human Human +DTXSID9058654 Days.Css NA 35 Days PBTK NA NA Human Human +DTXSID9058654 TK.Half.Life NA 181.2 hours 1compartment NA NA Human Human +DTXSID9058654 Css NA 3.816 mg/L 3compartmentss NA 50% Human Human +DTXSID9058654 Css NA 22.39 mg/L 3compartmentss NA 95% Human Human +DTXSID9058654 Css NA 2.995 mg/L PBTK NA 50% Human Human +DTXSID9058654 Css NA 17.49 mg/L PBTK NA 95% Human Human +DTXSID9058654 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID9058654 Fup 2.4e-08 NA NA https://doi.org/10.1093/toxsci/kfz205 NA Rat Human -DTXSID9058654 Vd NA 8.024 L/kg 1compartment NA NA Rat Human -DTXSID9058654 Days.Css NA 5 Days PBTK NA NA Rat Human -DTXSID9058654 TK.Half.Life NA 32.33 hours 1compartment NA NA Rat Human -DTXSID9058654 Css NA 0.1791 mg/L 3compartmentss NA 50% Rat Human -DTXSID9058654 Css NA 0.7669 mg/L 3compartmentss NA 95% Rat Human -DTXSID9058654 Css NA 0.2263 mg/L PBTK NA 50% Rat Human -DTXSID9058654 Css NA 1.041 mg/L PBTK NA 95% Rat Human -DTXSID90858931 Clint NA 19.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Human Human +DTXSID9058654 Vd NA 3.329 L/kg 1compartment NA NA Rat Human +DTXSID9058654 Days.Css NA 20 Days PBTK NA NA Rat Human +DTXSID9058654 TK.Half.Life NA 95.91 hours 1compartment NA NA Rat Human +DTXSID9058654 Css NA 0.4972 mg/L 3compartmentss NA 50% Rat Human +DTXSID9058654 Css NA 2.476 mg/L 3compartmentss NA 95% Rat Human +DTXSID9058654 Css NA 0.3916 mg/L PBTK NA 50% Rat Human +DTXSID9058654 Css NA 1.978 mg/L PBTK NA 95% Rat Human +DTXSID9061675 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9061675 Fup 0.0207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9061675 Vd NA 62.07 L/kg 1compartment NA NA Human Human +DTXSID9061675 Days.Css NA 467 Days PBTK NA NA Human Human +DTXSID9061675 TK.Half.Life NA 1826 hours 1compartment NA NA Human Human +DTXSID9061675 Css NA 0.3353 mg/L 3compartmentss NA 50% Human Human +DTXSID9061675 Css NA 2.076 mg/L 3compartmentss NA 95% Human Human +DTXSID9061675 Css NA 2.379 mg/L PBTK NA 50% Human Human +DTXSID9061675 Css NA 13.61 mg/L PBTK NA 95% Human Human +DTXSID9061675 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9061675 Fup 0.0207 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9061675 Vd NA 52.76 L/kg 1compartment NA NA Rat Human +DTXSID9061675 Days.Css NA 289 Days PBTK NA NA Rat Human +DTXSID9061675 TK.Half.Life NA 266 hours 1compartment NA NA Rat Human +DTXSID9061675 Css NA 0.03945 mg/L 3compartmentss NA 50% Rat Human +DTXSID9061675 Css NA 0.1905 mg/L 3compartmentss NA 95% Rat Human +DTXSID9061675 Css NA 0.3073 mg/L PBTK NA 50% Rat Human +DTXSID9061675 Css NA 1.573 mg/L PBTK NA 95% Rat Human +DTXSID9062304 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9062304 Fup 0.0698 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9062304 Vd NA 0.3323 L/kg 1compartment NA NA Human Human +DTXSID9062304 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9062304 TK.Half.Life NA 1.118 hours 1compartment NA NA Human Human +DTXSID9062304 Css NA 0.4181 mg/L 3compartmentss NA 50% Human Human +DTXSID9062304 Css NA 3.319 mg/L 3compartmentss NA 95% Human Human +DTXSID9062304 Css NA 0.2608 mg/L PBTK NA 50% Human Human +DTXSID9062304 Css NA 1.986 mg/L PBTK NA 95% Human Human +DTXSID9062304 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9062304 Fup 0.0698 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9062304 Vd NA 0.3257 L/kg 1compartment NA NA Rat Human +DTXSID9062304 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9062304 TK.Half.Life NA 0.673 hours 1compartment NA NA Rat Human +DTXSID9062304 Css NA 0.05604 mg/L 3compartmentss NA 50% Rat Human +DTXSID9062304 Css NA 0.3384 mg/L 3compartmentss NA 95% Rat Human +DTXSID9062304 Css NA 0.03383 mg/L PBTK NA 50% Rat Human +DTXSID9062304 Css NA 0.1984 mg/L PBTK NA 95% Rat Human +DTXSID9063900 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9063900 Fup 0.443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9063900 Vd NA 2.769 L/kg 1compartment NA NA Human Human +DTXSID9063900 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9063900 TK.Half.Life NA 2.104 hours 1compartment NA NA Human Human +DTXSID9063900 Css NA 0.02425 mg/L 3compartmentss NA 50% Human Human +DTXSID9063900 Css NA 0.2562 mg/L 3compartmentss NA 95% Human Human +DTXSID9063900 Css NA 0.02867 mg/L PBTK NA 50% Human Human +DTXSID9063900 Css NA 0.2271 mg/L PBTK NA 95% Human Human +DTXSID9063900 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9063900 Fup 0.443 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9063900 Vd NA 2.741 L/kg 1compartment NA NA Rat Human +DTXSID9063900 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9063900 TK.Half.Life NA 1.118 hours 1compartment NA NA Rat Human +DTXSID9063900 Css NA 0.002909 mg/L 3compartmentss NA 50% Rat Human +DTXSID9063900 Css NA 0.02338 mg/L 3compartmentss NA 95% Rat Human +DTXSID9063900 Css NA 0.003667 mg/L PBTK NA 50% Rat Human +DTXSID9063900 Css NA 0.02151 mg/L PBTK NA 95% Rat Human +DTXSID90648692 Clint 14.19 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90648692 Fup 0.0592 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90648692 Vd NA 1.04 L/kg 1compartment NA NA Human Human +DTXSID90648692 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90648692 TK.Half.Life NA 5.576 hours 1compartment NA NA Human Human +DTXSID90648692 Css NA 0.7404 mg/L 3compartmentss NA 50% Human Human +DTXSID90648692 Css NA 5.894 mg/L 3compartmentss NA 95% Human Human +DTXSID90648692 Css NA 0.4666 mg/L PBTK NA 50% Human Human +DTXSID90648692 Css NA 3.59 mg/L PBTK NA 95% Human Human +DTXSID90648692 Clint 14.19 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90648692 Fup 0.0592 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90648692 Vd NA 0.797 L/kg 1compartment NA NA Rat Human +DTXSID90648692 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90648692 TK.Half.Life NA 2.438 hours 1compartment NA NA Rat Human +DTXSID90648692 Css NA 0.09744 mg/L 3compartmentss NA 50% Rat Human +DTXSID90648692 Css NA 0.5496 mg/L 3compartmentss NA 95% Rat Human +DTXSID90648692 Css NA 0.05948 mg/L PBTK NA 50% Rat Human +DTXSID90648692 Css NA 0.3247 mg/L PBTK NA 95% Rat Human +DTXSID9065867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9065867 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID9065867 Vd NA 1.093 L/kg 1compartment NA NA Human Human +DTXSID9065867 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID9065867 TK.Half.Life NA 1.687 hours 1compartment NA NA Human Human +DTXSID9065867 Css NA 0.09616 mg/L 3compartmentss NA 50% Human Human +DTXSID9065867 Css NA 0.6747 mg/L 3compartmentss NA 95% Human Human +DTXSID9065867 Css NA 0.06848 mg/L PBTK NA 50% Human Human +DTXSID9065867 Css NA 0.4491 mg/L PBTK NA 95% Human Human +DTXSID9065867 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9065867 Fup 0.23 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID9065867 Vd NA 0.9025 L/kg 1compartment NA NA Rat Human +DTXSID9065867 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID9065867 TK.Half.Life NA 0.7282 hours 1compartment NA NA Rat Human +DTXSID9065867 Css NA 0.01199 mg/L 3compartmentss NA 50% Rat Human +DTXSID9065867 Css NA 0.06376 mg/L 3compartmentss NA 95% Rat Human +DTXSID9065867 Css NA 0.008535 mg/L PBTK NA 50% Rat Human +DTXSID9065867 Css NA 0.04237 mg/L PBTK NA 95% Rat Human +DTXSID90659061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90659061 Fup 0.0175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90659061 Vd NA 2.465 L/kg 1compartment NA NA Human Human +DTXSID90659061 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID90659061 TK.Half.Life NA 31.05 hours 1compartment NA NA Human Human +DTXSID90659061 Css NA 1.762 mg/L 3compartmentss NA 50% Human Human +DTXSID90659061 Css NA 13.45 mg/L 3compartmentss NA 95% Human Human +DTXSID90659061 Css NA 1.166 mg/L PBTK NA 50% Human Human +DTXSID90659061 Css NA 8.523 mg/L PBTK NA 95% Human Human +DTXSID90659061 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90659061 Fup 0.0175 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90659061 Vd NA 1.867 L/kg 1compartment NA NA Rat Human +DTXSID90659061 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID90659061 TK.Half.Life NA 8.403 hours 1compartment NA NA Rat Human +DTXSID90659061 Css NA 0.2185 mg/L 3compartmentss NA 50% Rat Human +DTXSID90659061 Css NA 1.428 mg/L 3compartmentss NA 95% Rat Human +DTXSID90659061 Css NA 0.143 mg/L PBTK NA 50% Rat Human +DTXSID90659061 Css NA 0.8817 mg/L PBTK NA 95% Rat Human +DTXSID90858931 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human DTXSID90858931 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human DTXSID90858931 Vd NA 6.4 L/kg 1compartment NA NA Human Human -DTXSID90858931 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID90858931 TK.Half.Life NA 4.575 hours 1compartment NA NA Human Human -DTXSID90858931 Css NA 0.02607 mg/L 3compartmentss NA 50% Human Human -DTXSID90858931 Css NA 0.2593 mg/L 3compartmentss NA 95% Human Human -DTXSID90858931 Css NA 0.02386 mg/L PBTK NA 50% Human Human -DTXSID90858931 Css NA 0.1969 mg/L PBTK NA 95% Human Human -DTXSID90858931 Clint NA 19.77 uL/min/million hepatocytes ADMet https://doi.org/10.1021/acs.est.7b00650 NA Rat Human +DTXSID90858931 Days.Css NA 7 Days PBTK NA NA Human Human +DTXSID90858931 TK.Half.Life NA 56.63 hours 1compartment NA NA Human Human +DTXSID90858931 Css NA 0.8016 mg/L 3compartmentss NA 50% Human Human +DTXSID90858931 Css NA 3.761 mg/L 3compartmentss NA 95% Human Human +DTXSID90858931 Css NA 0.8256 mg/L PBTK NA 50% Human Human +DTXSID90858931 Css NA 3.874 mg/L PBTK NA 95% Human Human +DTXSID90858931 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human DTXSID90858931 Fup 0.8 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human DTXSID90858931 Vd NA 6.569 L/kg 1compartment NA NA Rat Human -DTXSID90858931 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID90858931 TK.Half.Life NA 2.264 hours 1compartment NA NA Rat Human -DTXSID90858931 Css NA 0.013 mg/L 3compartmentss NA 50% Rat Human -DTXSID90858931 Css NA 0.1161 mg/L 3compartmentss NA 95% Rat Human -DTXSID90858931 Css NA 0.01198 mg/L PBTK NA 50% Rat Human -DTXSID90858931 Css NA 0.08251 mg/L PBTK NA 95% Rat Human +DTXSID90858931 Days.Css NA 2 Days PBTK NA NA Rat Human +DTXSID90858931 TK.Half.Life NA 18.51 hours 1compartment NA NA Rat Human +DTXSID90858931 Css NA 0.04679 mg/L 3compartmentss NA 50% Rat Human +DTXSID90858931 Css NA 0.201 mg/L 3compartmentss NA 95% Rat Human +DTXSID90858931 Css NA 0.04991 mg/L PBTK NA 50% Rat Human +DTXSID90858931 Css NA 0.2145 mg/L PBTK NA 95% Rat Human +DTXSID90861127 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90861127 Fup 0.41 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90861127 Vd NA 3.021 L/kg 1compartment NA NA Human Human +DTXSID90861127 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90861127 TK.Half.Life NA 2.67 hours 1compartment NA NA Human Human +DTXSID90861127 Css NA 0.03252 mg/L 3compartmentss NA 50% Human Human +DTXSID90861127 Css NA 0.2876 mg/L 3compartmentss NA 95% Human Human +DTXSID90861127 Css NA 0.03482 mg/L PBTK NA 50% Human Human +DTXSID90861127 Css NA 0.2539 mg/L PBTK NA 95% Human Human +DTXSID90861127 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90861127 Fup 0.41 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90861127 Vd NA 3.021 L/kg 1compartment NA NA Rat Human +DTXSID90861127 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90861127 TK.Half.Life NA 1.407 hours 1compartment NA NA Rat Human +DTXSID90861127 Css NA 0.003548 mg/L 3compartmentss NA 50% Rat Human +DTXSID90861127 Css NA 0.02583 mg/L 3compartmentss NA 95% Rat Human +DTXSID90861127 Css NA 0.004031 mg/L PBTK NA 50% Rat Human +DTXSID90861127 Css NA 0.02221 mg/L PBTK NA 95% Rat Human +DTXSID90862795 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90862795 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90862795 Vd NA 1.424 L/kg 1compartment NA NA Human Human +DTXSID90862795 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID90862795 TK.Half.Life NA 21.65 hours 1compartment NA NA Human Human +DTXSID90862795 Css NA 1.514 mg/L 3compartmentss NA 50% Human Human +DTXSID90862795 Css NA 7.527 mg/L 3compartmentss NA 95% Human Human +DTXSID90862795 Css NA 1.27 mg/L PBTK NA 50% Human Human +DTXSID90862795 Css NA 5.043 mg/L PBTK NA 95% Human Human +DTXSID90862795 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90862795 Fup 0.504 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90862795 Vd NA 1.215 L/kg 1compartment NA NA Rat Human +DTXSID90862795 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90862795 TK.Half.Life NA 5.55 hours 1compartment NA NA Rat Human +DTXSID90862795 Css NA 0.09336 mg/L 3compartmentss NA 50% Rat Human +DTXSID90862795 Css NA 0.4315 mg/L 3compartmentss NA 95% Rat Human +DTXSID90862795 Css NA 0.07832 mg/L PBTK NA 50% Rat Human +DTXSID90862795 Css NA 0.2759 mg/L PBTK NA 95% Rat Human +DTXSID90869249 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90869249 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90869249 Vd NA 0.3295 L/kg 1compartment NA NA Human Human +DTXSID90869249 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID90869249 TK.Half.Life NA 13.33 hours 1compartment NA NA Human Human +DTXSID90869249 Css NA 2.965 mg/L 3compartmentss NA 50% Human Human +DTXSID90869249 Css NA 13.21 mg/L 3compartmentss NA 95% Human Human +DTXSID90869249 Css NA 1.89 mg/L PBTK NA 50% Human Human +DTXSID90869249 Css NA 7.818 mg/L PBTK NA 95% Human Human +DTXSID90869249 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90869249 Fup 0.16 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90869249 Vd NA 0.3313 L/kg 1compartment NA NA Rat Human +DTXSID90869249 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90869249 TK.Half.Life NA 4.566 hours 1compartment NA NA Rat Human +DTXSID90869249 Css NA 0.01646 mg/L 3compartmentss NA 50% Rat Human +DTXSID90869249 Css NA 0.07342 mg/L 3compartmentss NA 95% Rat Human +DTXSID90869249 Css NA 0.009845 mg/L PBTK NA 50% Rat Human +DTXSID90869249 Css NA 0.04172 mg/L PBTK NA 95% Rat Human +DTXSID90870012 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90870012 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90870012 Vd NA 0.1641 L/kg 1compartment NA NA Human Human +DTXSID90870012 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID90870012 TK.Half.Life NA 14.37 hours 1compartment NA NA Human Human +DTXSID90870012 Css NA 14.35 mg/L 3compartmentss NA 50% Human Human +DTXSID90870012 Css NA 138.6 mg/L 3compartmentss NA 95% Human Human +DTXSID90870012 Css NA 8.399 mg/L PBTK NA 50% Human Human +DTXSID90870012 Css NA 79.49 mg/L PBTK NA 95% Human Human +DTXSID90870012 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90870012 Fup 0.002 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90870012 Vd NA 0.1613 L/kg 1compartment NA NA Rat Human +DTXSID90870012 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID90870012 TK.Half.Life NA 9.596 hours 1compartment NA NA Rat Human +DTXSID90870012 Css NA 0.715 mg/L 3compartmentss NA 50% Rat Human +DTXSID90870012 Css NA 7.467 mg/L 3compartmentss NA 95% Rat Human +DTXSID90870012 Css NA 0.3942 mg/L PBTK NA 50% Rat Human +DTXSID90870012 Css NA 4.132 mg/L PBTK NA 95% Rat Human +DTXSID90872319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90872319 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90872319 Vd NA 0.8322 L/kg 1compartment NA NA Human Human +DTXSID90872319 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90872319 TK.Half.Life NA 1.537 hours 1compartment NA NA Human Human +DTXSID90872319 Css NA 0.1431 mg/L 3compartmentss NA 50% Human Human +DTXSID90872319 Css NA 1.011 mg/L 3compartmentss NA 95% Human Human +DTXSID90872319 Css NA 0.09617 mg/L PBTK NA 50% Human Human +DTXSID90872319 Css NA 0.6347 mg/L PBTK NA 95% Human Human +DTXSID90872319 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90872319 Fup 0.167 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90872319 Vd NA 0.6954 L/kg 1compartment NA NA Rat Human +DTXSID90872319 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90872319 TK.Half.Life NA 0.7054 hours 1compartment NA NA Rat Human +DTXSID90872319 Css NA 0.01825 mg/L 3compartmentss NA 50% Rat Human +DTXSID90872319 Css NA 0.09954 mg/L 3compartmentss NA 95% Rat Human +DTXSID90872319 Css NA 0.01213 mg/L PBTK NA 50% Rat Human +DTXSID90872319 Css NA 0.06325 mg/L PBTK NA 95% Rat Human +DTXSID90872935 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Human Human +DTXSID90872935 Fup 0.033 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90872935 Vd NA 0.4205 L/kg 1compartment NA NA Human Human +DTXSID90872935 Days.Css NA 2 Days PBTK NA NA Human Human +DTXSID90872935 TK.Half.Life NA 18.96 hours 1compartment NA NA Human Human +DTXSID90872935 Css NA 6.169 mg/L 3compartmentss NA 50% Human Human +DTXSID90872935 Css NA 39.35 mg/L 3compartmentss NA 95% Human Human +DTXSID90872935 Css NA 4.749 mg/L PBTK NA 50% Human Human +DTXSID90872935 Css NA 30.29 mg/L PBTK NA 95% Human Human +DTXSID90872935 Clint 2 NA uL/min/million hepatocytes NA Williamson 2020 NA Rat Human +DTXSID90872935 Fup 0.033 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90872935 Vd NA 0.489 L/kg 1compartment NA NA Rat Human +DTXSID90872935 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90872935 TK.Half.Life NA 8.191 hours 1compartment NA NA Rat Human +DTXSID90872935 Css NA 0.4004 mg/L 3compartmentss NA 50% Rat Human +DTXSID90872935 Css NA 1.862 mg/L 3compartmentss NA 95% Rat Human +DTXSID90872935 Css NA 0.3192 mg/L PBTK NA 50% Rat Human +DTXSID90872935 Css NA 1.485 mg/L PBTK NA 95% Rat Human +DTXSID90873225 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90873225 Fup 0.47 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90873225 Vd NA 4.092 L/kg 1compartment NA NA Human Human +DTXSID90873225 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90873225 TK.Half.Life NA 10.81 hours 1compartment NA NA Human Human +DTXSID90873225 Css NA 0.1824 mg/L 3compartmentss NA 50% Human Human +DTXSID90873225 Css NA 1.111 mg/L 3compartmentss NA 95% Human Human +DTXSID90873225 Css NA 0.1935 mg/L PBTK NA 50% Human Human +DTXSID90873225 Css NA 1.008 mg/L PBTK NA 95% Human Human +DTXSID90873225 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90873225 Fup 0.47 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90873225 Vd NA 3.719 L/kg 1compartment NA NA Rat Human +DTXSID90873225 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90873225 TK.Half.Life NA 3.642 hours 1compartment NA NA Rat Human +DTXSID90873225 Css NA 0.02073 mg/L 3compartmentss NA 50% Rat Human +DTXSID90873225 Css NA 0.102 mg/L 3compartmentss NA 95% Rat Human +DTXSID90873225 Css NA 0.02288 mg/L PBTK NA 50% Rat Human +DTXSID90873225 Css NA 0.08878 mg/L PBTK NA 95% Rat Human +DTXSID90873361 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90873361 Fup 0.013 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90873361 Vd NA 0.2793 L/kg 1compartment NA NA Human Human +DTXSID90873361 Days.Css NA 1 Days PBTK NA NA Human Human +DTXSID90873361 TK.Half.Life NA 11.89 hours 1compartment NA NA Human Human +DTXSID90873361 Css NA 6.854 mg/L 3compartmentss NA 50% Human Human +DTXSID90873361 Css NA 58.71 mg/L 3compartmentss NA 95% Human Human +DTXSID90873361 Css NA 4.003 mg/L PBTK NA 50% Human Human +DTXSID90873361 Css NA 34.36 mg/L PBTK NA 95% Human Human +DTXSID90873361 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90873361 Fup 0.013 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90873361 Vd NA 0.2393 L/kg 1compartment NA NA Rat Human +DTXSID90873361 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90873361 TK.Half.Life NA 6.484 hours 1compartment NA NA Rat Human +DTXSID90873361 Css NA 0.3166 mg/L 3compartmentss NA 50% Rat Human +DTXSID90873361 Css NA 3.137 mg/L 3compartmentss NA 95% Rat Human +DTXSID90873361 Css NA 0.1768 mg/L PBTK NA 50% Rat Human +DTXSID90873361 Css NA 1.748 mg/L PBTK NA 95% Rat Human DTXSID90873366 Clint 7.399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Human Human DTXSID90873366 Fup 0.15 NA NA https://doi.org/10.1124/dmd.117.077040 NA Human Human -DTXSID90873366 Vd NA 3.183 L/kg 1compartment NA NA Human Human +DTXSID90873366 Vd NA 2.669 L/kg 1compartment NA NA Human Human DTXSID90873366 Days.Css NA 0 Days PBTK NA NA Human Human -DTXSID90873366 TK.Half.Life NA 9.282 hours 1compartment NA NA Human Human -DTXSID90873366 Css NA 0.2462 mg/L 3compartmentss NA 50% Human Human -DTXSID90873366 Css NA 2.127 mg/L 3compartmentss NA 95% Human Human -DTXSID90873366 Css NA 0.242 mg/L PBTK NA 50% Human Human -DTXSID90873366 Css NA 1.639 mg/L PBTK NA 95% Human Human +DTXSID90873366 TK.Half.Life NA 7.641 hours 1compartment NA NA Human Human +DTXSID90873366 Css NA 0.2384 mg/L 3compartmentss NA 50% Human Human +DTXSID90873366 Css NA 2.056 mg/L 3compartmentss NA 95% Human Human +DTXSID90873366 Css NA 0.2277 mg/L PBTK NA 50% Human Human +DTXSID90873366 Css NA 1.574 mg/L PBTK NA 95% Human Human DTXSID90873366 Clint 7.399 NA uL/min/million hepatocytes NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human DTXSID90873366 Fup 0.15 NA NA https://doi.org/10.1124/dmd.117.077040 NA Rat Human -DTXSID90873366 Vd NA 3.147 L/kg 1compartment NA NA Rat Human +DTXSID90873366 Vd NA 2.673 L/kg 1compartment NA NA Rat Human DTXSID90873366 Days.Css NA 0 Days PBTK NA NA Rat Human -DTXSID90873366 TK.Half.Life NA 5.307 hours 1compartment NA NA Rat Human -DTXSID90873366 Css NA 0.128 mg/L 3compartmentss NA 50% Rat Human -DTXSID90873366 Css NA 0.8471 mg/L 3compartmentss NA 95% Rat Human -DTXSID90873366 Css NA 0.1234 mg/L PBTK NA 50% Rat Human -DTXSID90873366 Css NA 0.6263 mg/L PBTK NA 95% Rat Human +DTXSID90873366 TK.Half.Life NA 4.671 hours 1compartment NA NA Rat Human +DTXSID90873366 Css NA 0.02862 mg/L 3compartmentss NA 50% Rat Human +DTXSID90873366 Css NA 0.201 mg/L 3compartmentss NA 95% Rat Human +DTXSID90873366 Css NA 0.02774 mg/L PBTK NA 50% Rat Human +DTXSID90873366 Css NA 0.1461 mg/L PBTK NA 95% Rat Human +DTXSID90873381 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90873381 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90873381 Vd NA 0.3759 L/kg 1compartment NA NA Human Human +DTXSID90873381 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90873381 TK.Half.Life NA 0.6601 hours 1compartment NA NA Human Human +DTXSID90873381 Css NA 0.06875 mg/L 3compartmentss NA 50% Human Human +DTXSID90873381 Css NA 0.5968 mg/L 3compartmentss NA 95% Human Human +DTXSID90873381 Css NA 0.04774 mg/L PBTK NA 50% Human Human +DTXSID90873381 Css NA 0.3783 mg/L PBTK NA 95% Human Human +DTXSID90873381 Clint 6.25 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90873381 Fup 0.5 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90873381 Vd NA 0.388 L/kg 1compartment NA NA Rat Human +DTXSID90873381 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90873381 TK.Half.Life NA 0.3691 hours 1compartment NA NA Rat Human +DTXSID90873381 Css NA 0.0006334 mg/L 3compartmentss NA 50% Rat Human +DTXSID90873381 Css NA 0.004976 mg/L 3compartmentss NA 95% Rat Human +DTXSID90873381 Css NA 0.0004201 mg/L PBTK NA 50% Rat Human +DTXSID90873381 Css NA 0.002954 mg/L PBTK NA 95% Rat Human +DTXSID90873467 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90873467 Fup 0.022 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90873467 Vd NA 3.119 L/kg 1compartment NA NA Human Human +DTXSID90873467 Days.Css NA 14 Days PBTK NA NA Human Human +DTXSID90873467 TK.Half.Life NA 89.42 hours 1compartment NA NA Human Human +DTXSID90873467 Css NA 1.878 mg/L 3compartmentss NA 50% Human Human +DTXSID90873467 Css NA 12.48 mg/L 3compartmentss NA 95% Human Human +DTXSID90873467 Css NA 1.296 mg/L PBTK NA 50% Human Human +DTXSID90873467 Css NA 8.414 mg/L PBTK NA 95% Human Human +DTXSID90873467 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90873467 Fup 0.022 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90873467 Vd NA 2.337 L/kg 1compartment NA NA Rat Human +DTXSID90873467 Days.Css NA 8 Days PBTK NA NA Rat Human +DTXSID90873467 TK.Half.Life NA 12.08 hours 1compartment NA NA Rat Human +DTXSID90873467 Css NA 0.02018 mg/L 3compartmentss NA 50% Rat Human +DTXSID90873467 Css NA 0.1336 mg/L 3compartmentss NA 95% Rat Human +DTXSID90873467 Css NA 0.01346 mg/L PBTK NA 50% Rat Human +DTXSID90873467 Css NA 0.08744 mg/L PBTK NA 95% Rat Human +DTXSID90875704 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90875704 Fup 0.534 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90875704 Vd NA 1.324 L/kg 1compartment NA NA Human Human +DTXSID90875704 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90875704 TK.Half.Life NA 1.266 hours 1compartment NA NA Human Human +DTXSID90875704 Css NA 0.03728 mg/L 3compartmentss NA 50% Human Human +DTXSID90875704 Css NA 0.3483 mg/L 3compartmentss NA 95% Human Human +DTXSID90875704 Css NA 0.03092 mg/L PBTK NA 50% Human Human +DTXSID90875704 Css NA 0.2416 mg/L PBTK NA 95% Human Human +DTXSID90875704 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90875704 Fup 0.534 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90875704 Vd NA 1.152 L/kg 1compartment NA NA Rat Human +DTXSID90875704 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90875704 TK.Half.Life NA 0.5373 hours 1compartment NA NA Rat Human +DTXSID90875704 Css NA 0.004514 mg/L 3compartmentss NA 50% Rat Human +DTXSID90875704 Css NA 0.03579 mg/L 3compartmentss NA 95% Rat Human +DTXSID90875704 Css NA 0.003833 mg/L PBTK NA 50% Rat Human +DTXSID90875704 Css NA 0.02468 mg/L PBTK NA 95% Rat Human +DTXSID90879808 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90879808 Fup 0.761 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90879808 Vd NA 1.001 L/kg 1compartment NA NA Human Human +DTXSID90879808 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90879808 TK.Half.Life NA 8.587 hours 1compartment NA NA Human Human +DTXSID90879808 Css NA 0.9538 mg/L 3compartmentss NA 50% Human Human +DTXSID90879808 Css NA 6.207 mg/L 3compartmentss NA 95% Human Human +DTXSID90879808 Css NA 0.8218 mg/L PBTK NA 50% Human Human +DTXSID90879808 Css NA 4.03 mg/L PBTK NA 95% Human Human +DTXSID90879808 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90879808 Fup 0.761 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90879808 Vd NA 1.003 L/kg 1compartment NA NA Rat Human +DTXSID90879808 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90879808 TK.Half.Life NA 2.912 hours 1compartment NA NA Rat Human +DTXSID90879808 Css NA 0.05646 mg/L 3compartmentss NA 50% Rat Human +DTXSID90879808 Css NA 0.3576 mg/L 3compartmentss NA 95% Rat Human +DTXSID90879808 Css NA 0.04905 mg/L PBTK NA 50% Rat Human +DTXSID90879808 Css NA 0.2242 mg/L PBTK NA 95% Rat Human +DTXSID90880671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880671 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880671 Vd NA 3.686 L/kg 1compartment NA NA Human Human +DTXSID90880671 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90880671 TK.Half.Life NA 2.505 hours 1compartment NA NA Human Human +DTXSID90880671 Css NA 0.0187 mg/L 3compartmentss NA 50% Human Human +DTXSID90880671 Css NA 0.1945 mg/L 3compartmentss NA 95% Human Human +DTXSID90880671 Css NA 0.02664 mg/L PBTK NA 50% Human Human +DTXSID90880671 Css NA 0.2062 mg/L PBTK NA 95% Human Human +DTXSID90880671 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880671 Fup 0.356 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880671 Vd NA 3.66 L/kg 1compartment NA NA Rat Human +DTXSID90880671 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90880671 TK.Half.Life NA 1.357 hours 1compartment NA NA Rat Human +DTXSID90880671 Css NA 0.00227 mg/L 3compartmentss NA 50% Rat Human +DTXSID90880671 Css NA 0.01825 mg/L 3compartmentss NA 95% Rat Human +DTXSID90880671 Css NA 0.003401 mg/L PBTK NA 50% Rat Human +DTXSID90880671 Css NA 0.01953 mg/L PBTK NA 95% Rat Human +DTXSID90880712 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880712 Fup 0.0396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880712 Vd NA 2.784 L/kg 1compartment NA NA Human Human +DTXSID90880712 Days.Css NA 3 Days PBTK NA NA Human Human +DTXSID90880712 TK.Half.Life NA 29.93 hours 1compartment NA NA Human Human +DTXSID90880712 Css NA 1.371 mg/L 3compartmentss NA 50% Human Human +DTXSID90880712 Css NA 9.567 mg/L 3compartmentss NA 95% Human Human +DTXSID90880712 Css NA 0.9274 mg/L PBTK NA 50% Human Human +DTXSID90880712 Css NA 6.127 mg/L PBTK NA 95% Human Human +DTXSID90880712 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880712 Fup 0.0396 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880712 Vd NA 2.086 L/kg 1compartment NA NA Rat Human +DTXSID90880712 Days.Css NA 1 Days PBTK NA NA Rat Human +DTXSID90880712 TK.Half.Life NA 6.08 hours 1compartment NA NA Rat Human +DTXSID90880712 Css NA 0.177 mg/L 3compartmentss NA 50% Rat Human +DTXSID90880712 Css NA 0.9983 mg/L 3compartmentss NA 95% Rat Human +DTXSID90880712 Css NA 0.1185 mg/L PBTK NA 50% Rat Human +DTXSID90880712 Css NA 0.6472 mg/L PBTK NA 95% Rat Human +DTXSID90880737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880737 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880737 Vd NA 1.762 L/kg 1compartment NA NA Human Human +DTXSID90880737 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90880737 TK.Half.Life NA 2.182 hours 1compartment NA NA Human Human +DTXSID90880737 Css NA 0.0629 mg/L 3compartmentss NA 50% Human Human +DTXSID90880737 Css NA 0.4578 mg/L 3compartmentss NA 95% Human Human +DTXSID90880737 Css NA 0.04949 mg/L PBTK NA 50% Human Human +DTXSID90880737 Css NA 0.3334 mg/L PBTK NA 95% Human Human +DTXSID90880737 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880737 Fup 0.387 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880737 Vd NA 1.423 L/kg 1compartment NA NA Rat Human +DTXSID90880737 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90880737 TK.Half.Life NA 0.8226 hours 1compartment NA NA Rat Human +DTXSID90880737 Css NA 0.007697 mg/L 3compartmentss NA 50% Rat Human +DTXSID90880737 Css NA 0.04482 mg/L 3compartmentss NA 95% Rat Human +DTXSID90880737 Css NA 0.006181 mg/L PBTK NA 50% Rat Human +DTXSID90880737 Css NA 0.03211 mg/L PBTK NA 95% Rat Human +DTXSID90880818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880818 Fup 0.0194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880818 Vd NA 2.999 L/kg 1compartment NA NA Human Human +DTXSID90880818 Days.Css NA 8 Days PBTK NA NA Human Human +DTXSID90880818 TK.Half.Life NA 61.34 hours 1compartment NA NA Human Human +DTXSID90880818 Css NA 2.537 mg/L 3compartmentss NA 50% Human Human +DTXSID90880818 Css NA 16.67 mg/L 3compartmentss NA 95% Human Human +DTXSID90880818 Css NA 1.739 mg/L PBTK NA 50% Human Human +DTXSID90880818 Css NA 11.08 mg/L PBTK NA 95% Human Human +DTXSID90880818 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880818 Fup 0.0194 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880818 Vd NA 2.245 L/kg 1compartment NA NA Rat Human +DTXSID90880818 Days.Css NA 5 Days PBTK NA NA Rat Human +DTXSID90880818 TK.Half.Life NA 9.763 hours 1compartment NA NA Rat Human +DTXSID90880818 Css NA 0.3292 mg/L 3compartmentss NA 50% Rat Human +DTXSID90880818 Css NA 1.862 mg/L 3compartmentss NA 95% Rat Human +DTXSID90880818 Css NA 0.2231 mg/L PBTK NA 50% Rat Human +DTXSID90880818 Css NA 1.224 mg/L PBTK NA 95% Rat Human +DTXSID90880919 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880919 Fup 0.762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90880919 Vd NA 0.9634 L/kg 1compartment NA NA Human Human +DTXSID90880919 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90880919 TK.Half.Life NA 8.409 hours 1compartment NA NA Human Human +DTXSID90880919 Css NA 0.9667 mg/L 3compartmentss NA 50% Human Human +DTXSID90880919 Css NA 6.263 mg/L 3compartmentss NA 95% Human Human +DTXSID90880919 Css NA 0.8264 mg/L PBTK NA 50% Human Human +DTXSID90880919 Css NA 4.064 mg/L PBTK NA 95% Human Human +DTXSID90880919 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880919 Fup 0.762 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90880919 Vd NA 0.924 L/kg 1compartment NA NA Rat Human +DTXSID90880919 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90880919 TK.Half.Life NA 2.691 hours 1compartment NA NA Rat Human +DTXSID90880919 Css NA 0.05728 mg/L 3compartmentss NA 50% Rat Human +DTXSID90880919 Css NA 0.3616 mg/L 3compartmentss NA 95% Rat Human +DTXSID90880919 Css NA 0.04916 mg/L PBTK NA 50% Rat Human +DTXSID90880919 Css NA 0.2258 mg/L PBTK NA 95% Rat Human +DTXSID90881229 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90881229 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90881229 Vd NA 0.8181 L/kg 1compartment NA NA Human Human +DTXSID90881229 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90881229 TK.Half.Life NA 8.891 hours 1compartment NA NA Human Human +DTXSID90881229 Css NA 1.008 mg/L 3compartmentss NA 50% Human Human +DTXSID90881229 Css NA 7.3 mg/L 3compartmentss NA 95% Human Human +DTXSID90881229 Css NA 0.8326 mg/L PBTK NA 50% Human Human +DTXSID90881229 Css NA 4.572 mg/L PBTK NA 95% Human Human +DTXSID90881229 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90881229 Fup 0.604 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90881229 Vd NA 0.8002 L/kg 1compartment NA NA Rat Human +DTXSID90881229 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90881229 TK.Half.Life NA 2.932 hours 1compartment NA NA Rat Human +DTXSID90881229 Css NA 0.0196 mg/L 3compartmentss NA 50% Rat Human +DTXSID90881229 Css NA 0.1696 mg/L 3compartmentss NA 95% Rat Human +DTXSID90881229 Css NA 0.01552 mg/L PBTK NA 50% Rat Human +DTXSID90881229 Css NA 0.1063 mg/L PBTK NA 95% Rat Human +DTXSID90881244 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90881244 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90881244 Vd NA 2.498 L/kg 1compartment NA NA Human Human +DTXSID90881244 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90881244 TK.Half.Life NA 6.383 hours 1compartment NA NA Human Human +DTXSID90881244 Css NA 0.212 mg/L 3compartmentss NA 50% Human Human +DTXSID90881244 Css NA 1.353 mg/L 3compartmentss NA 95% Human Human +DTXSID90881244 Css NA 0.1539 mg/L PBTK NA 50% Human Human +DTXSID90881244 Css NA 0.9424 mg/L PBTK NA 95% Human Human +DTXSID90881244 Clint 21.7 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90881244 Fup 0.214 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90881244 Vd NA 1.905 L/kg 1compartment NA NA Rat Human +DTXSID90881244 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90881244 TK.Half.Life NA 1.78 hours 1compartment NA NA Rat Human +DTXSID90881244 Css NA 0.0267 mg/L 3compartmentss NA 50% Rat Human +DTXSID90881244 Css NA 0.1348 mg/L 3compartmentss NA 95% Rat Human +DTXSID90881244 Css NA 0.01937 mg/L PBTK NA 50% Rat Human +DTXSID90881244 Css NA 0.09201 mg/L PBTK NA 95% Rat Human +DTXSID90881249 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90881249 Fup 0.763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90881249 Vd NA 0.5345 L/kg 1compartment NA NA Human Human +DTXSID90881249 Days.Css NA 0 Days PBTK NA NA Human Human +DTXSID90881249 TK.Half.Life NA 4.533 hours 1compartment NA NA Human Human +DTXSID90881249 Css NA 0.9248 mg/L 3compartmentss NA 50% Human Human +DTXSID90881249 Css NA 5.755 mg/L 3compartmentss NA 95% Human Human +DTXSID90881249 Css NA 0.7129 mg/L PBTK NA 50% Human Human +DTXSID90881249 Css NA 3.613 mg/L PBTK NA 95% Human Human +DTXSID90881249 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90881249 Fup 0.763 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90881249 Vd NA 0.5556 L/kg 1compartment NA NA Rat Human +DTXSID90881249 Days.Css NA 0 Days PBTK NA NA Rat Human +DTXSID90881249 TK.Half.Life NA 1.605 hours 1compartment NA NA Rat Human +DTXSID90881249 Css NA 0.0177 mg/L 3compartmentss NA 50% Rat Human +DTXSID90881249 Css NA 0.1312 mg/L 3compartmentss NA 95% Rat Human +DTXSID90881249 Css NA 0.01312 mg/L PBTK NA 50% Rat Human +DTXSID90881249 Css NA 0.08273 mg/L PBTK NA 95% Rat Human +DTXSID90978825 Clint 14.19 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90978825 Fup 0.0164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90978825 Vd NA 2.991 L/kg 1compartment NA NA Human Human +DTXSID90978825 Days.Css NA 16 Days PBTK NA NA Human Human +DTXSID90978825 TK.Half.Life NA 95.5 hours 1compartment NA NA Human Human +DTXSID90978825 Css NA 4.043 mg/L 3compartmentss NA 50% Human Human +DTXSID90978825 Css NA 27.37 mg/L 3compartmentss NA 95% Human Human +DTXSID90978825 Css NA 2.762 mg/L PBTK NA 50% Human Human +DTXSID90978825 Css NA 17.89 mg/L PBTK NA 95% Human Human +DTXSID90978825 Clint 14.19 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90978825 Fup 0.0164 NA NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90978825 Vd NA 2.239 L/kg 1compartment NA NA Rat Human +DTXSID90978825 Days.Css NA 9 Days PBTK NA NA Rat Human +DTXSID90978825 TK.Half.Life NA 15.08 hours 1compartment NA NA Rat Human +DTXSID90978825 Css NA 0.519 mg/L 3compartmentss NA 50% Rat Human +DTXSID90978825 Css NA 3.001 mg/L 3compartmentss NA 95% Rat Human +DTXSID90978825 Css NA 0.3508 mg/L PBTK NA 50% Rat Human +DTXSID90978825 Css NA 1.982 mg/L PBTK NA 95% Rat Human +DTXSID90993235 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Human Human +DTXSID90993235 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Human Human +DTXSID90993235 Vd NA 0.8003 L/kg 1compartment NA NA Human Human +DTXSID90993235 Days.Css NA 15 Days PBTK NA NA Human Human +DTXSID90993235 TK.Half.Life NA 78.64 hours 1compartment NA NA Human Human +DTXSID90993235 Css NA 12.99 mg/L 3compartmentss NA 50% Human Human +DTXSID90993235 Css NA 57.87 mg/L 3compartmentss NA 95% Human Human +DTXSID90993235 Css NA 8.238 mg/L PBTK NA 50% Human Human +DTXSID90993235 Css NA 34.03 mg/L PBTK NA 95% Human Human +DTXSID90993235 Clint 0 NA uL/min/million hepatocytes NA https://doi.org/10.1021/acs.est.0c06117 NA Rat Human +DTXSID90993235 Fup 0.07 NA NA https://doi.org/10.1124/dmd.118.082966 NA Rat Human +DTXSID90993235 Vd NA 0.6706 L/kg 1compartment NA NA Rat Human +DTXSID90993235 Days.Css NA 3 Days PBTK NA NA Rat Human +DTXSID90993235 TK.Half.Life NA 21.44 hours 1compartment NA NA Rat Human +DTXSID90993235 Css NA 0.3119 mg/L 3compartmentss NA 50% Rat Human +DTXSID90993235 Css NA 1.844 mg/L 3compartmentss NA 95% Rat Human +DTXSID90993235 Css NA 0.1918 mg/L PBTK NA 50% Rat Human +DTXSID90993235 Css NA 1.073 mg/L PBTK NA 95% Rat Human +DTXSID0021961 Vd 2.2 NA L/kg NA National Toxicology Program NA rat NA +DTXSID0021961 Vd 2.7 NA L/kg NA National Toxicology Program NA mouse NA +DTXSID1020198 Vd 3.1 NA L/kg NA National Toxicology Program NA rat NA +DTXSID3022405 Vd 0.94 NA L/kg NA National Toxicology Program NA mouse NA +DTXSID3037707 Vd 0.24 NA L/kg NA National Toxicology Program NA rat NA +DTXSID5024219 Vd 1.7 NA L/kg NA National Toxicology Program NA rat NA +DTXSID7022253 Vd 6.6 NA L/kg NA Wambaugh et al. (2018) NA rat NA +DTXSID80108992 Vd 0.33 NA L/kg NA National Toxicology Program NA rat NA +DTXSID8031865 Vd 1 NA L/kg NA Wambaugh et al. (2018) NA rat NA +DTXSID0020442 Vd 0.05 NA L/kg NA National Toxicology Program NA hamster NA +DTXSID0020442 Vd 0.12 NA L/kg NA National Toxicology Program NA mouse NA +DTXSID1021116 Vd 0.36 NA L/kg NA Mico et al. (1988) NA dog NA +DTXSID1051432 Vd 0.41 NA L/kg NA National Toxicology Program NA rat NA +DTXSID3031860 Vd 0.25 NA L/kg NA National Toxicology Program NA rat NA +DTXSID3031862 Vd 1.1 NA L/kg NA National Toxicology Program NA rat NA +DTXSID3037709 Vd 0.28 NA L/kg NA National Toxicology Program NA rat NA +DTXSID5032498 Vd 1.8 NA L/kg NA Wambaugh et al. (2018) NA rat NA +DTXSID6023947 Vd 1.5 NA L/kg NA National Toxicology Program NA rat NA +DTXSID8022292 Vd 50 NA L/kg NA Wambaugh et al. (2018) NA rat NA +DTXSID0020365 Vd 1.2 NA L/kg NA Wambaugh et al. (2018) NA rat NA +DTXSID1026118 Vd 0.46 NA L/kg NA National Toxicology Program NA rat NA +DTXSID50881104 Vd 2.2 NA L/kg NA Wambaugh et al. (2018) NA rat NA +DTXSID2039336 Vd 14 NA L/kg NA Wambaugh et al. (2018) NA rat NA +DTXSID30575892 Vd 1.5 NA L/kg NA National Toxicology Program NA rat NA +DTXSID0020868 Vd 0.82 NA L/kg NA Angelo et al. (1986) NA mouse NA +DTXSID2020682 Vd 6.3 NA L/kg NA National Toxicology Program NA rat NA +DTXSID5020029 Vd 0.64 NA L/kg NA Gargas et al. (1995) NA rat NA +DTXSID5032600 Vd 0.2 NA L/kg NA Wambaugh et al. (2018) NA rat NA +DTXSID3034872 Vd 3.6 NA L/kg NA Wambaugh et al. (2018) NA rat NA +DTXSID7021106 Vd 0.091 NA L/kg NA National Toxicology Program NA rat NA +DTXSID8020913 Vd 0.64 NA L/kg NA National Toxicology Program NA rat NA +DTXSID3026148 Vd 3.2 NA L/kg NA National Toxicology Program NA rat NA +DTXSID7029904 Vd 1.4 NA L/kg NA National Toxicology Program NA rat NA +DTXSID9030258 Vd 1.2 NA L/kg NA National Toxicology Program NA rat NA +DTXSID0021961 Fsysbio 0.29 NA fraction NA National Toxicology Program NA rat NA +DTXSID0021961 Fsysbio 0.26 NA fraction NA National Toxicology Program NA mouse NA +DTXSID1023815 Fsysbio 1 NA fraction NA National Toxicology Program NA rat NA +DTXSID2032390 Fsysbio 0 NA fraction NA Wambaugh et al. (2018) NA rat NA +DTXSID3022405 Fsysbio 0.013 NA fraction NA National Toxicology Program NA mouse NA +DTXSID3022405 Fsysbio 0 NA fraction NA National Toxicology Program NA rat NA +DTXSID3037707 Fsysbio 0.79 NA fraction NA National Toxicology Program NA rat NA +DTXSID4021268 Fsysbio 0.018 NA fraction NA Wambaugh et al. (2018) NA rat NA +DTXSID4032405 Fsysbio 0.5 NA fraction NA Wambaugh et al. (2018) NA rat NA +DTXSID5024219 Fsysbio 0.68 NA fraction NA National Toxicology Program NA rat NA +DTXSID5032442 Fsysbio 1 NA fraction NA Wambaugh et al. (2018) NA rat NA +DTXSID5037523 Fsysbio 0.77 NA fraction NA Wambaugh et al. (2018) NA rat NA +DTXSID7022253 Fsysbio 4.6e-05 NA fraction NA Wambaugh et al. (2018) NA rat NA +DTXSID80108992 Fsysbio 1 NA fraction NA National Toxicology Program NA rat NA +DTXSID8023393 Fsysbio 0.014 NA fraction NA Wambaugh et al. (2018) NA rat NA +DTXSID8031865 Fsysbio 0.77 NA fraction NA Wambaugh et al. (2018) NA rat NA +DTXSID9032329 Fsysbio 0 NA fraction NA Wambaugh et al. (2018) NA rat NA +DTXSID0020442 Fsysbio 0.22 NA fraction NA Wambaugh et al. 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zT95?lxMSds-M-0#hu*=hGN82VLE2W^ZQml+VR5HVv7vR^j;72)xr#{byr@t(yg8j7 zonE}Cy*Oech!e&~I}{1e50H~@U$tIW@Sc)*apSK^53y86D=x2H8xx!J>&@(>+^Jim z4`O#)to=NMF9fHC}xX zn{yC{7%A-ae{$d~{H&gSZ~Ex<7I&p1O*76Pp^H-gh;tNwdWZX~4{LOiMIQ^T_c&PP I?V_CjAAMPYLjV8( diff --git a/scripts/httk-for-dashboard.R b/scripts/httk-for-dashboard.R index f203b72d..2d35e904 100644 --- a/scripts/httk-for-dashboard.R +++ b/scripts/httk-for-dashboard.R @@ -31,7 +31,7 @@ SPECIES.LIST <- c("Human","Rat") MODELS.LIST <- c("3compartmentss","PBTK") # How many processors are available for parallel computing: -NUM.CPU <- 6 +NUM.CPU <- detectCores()-1 # Add the in silico predictions: # Categorical QSPR: @@ -275,18 +275,18 @@ make.ccd.table <- function( } # Create a multicore cluster: -cl <- parallel::makeCluster(detectCores()-1) +cl <- parallel::makeCluster(NUM.CPU) # Load httk on all cores: clusterEvalQ(cl, library(httk)) # Clear memory all cores: clusterEvalQ(cl, rm(list=ls())) -# Load ADMet predicitons: -clusterEvalQ(cl, load_sipes2017()) + # Define the table creator function on all cores: clusterExport(cl, "make.ccd.table") # Share data with all cores: clusterExport(cl, c( + "chem.physical_and_invitro.data", "HTTK.data.list", "SPECIES.LIST", "MODELS.LIST", @@ -297,20 +297,21 @@ clusterExport(cl, c( "WHICH.QUANTILES", "NUM.SAMPLES")) -dashboard.list <- NULL -for (this.id in all.ids) - dashboard.list[[this.id]] <- make.ccd.table( - this.id=this.id, - HTTK.data.list=HTTK.data.list, - species.list=SPECIES.LIST, - model.list=MODELS.LIST, - param.list=param.list, - units.list=units.list, - all.ids=all.ids, - RANDOM.SEED=RANDOM.SEED, - which.quantiles=WHICH.QUANTILES, - num.samples=NUM.SAMPLES - ) +# Non-parallel version: +# dashboard.list <- NULL +# for (this.id in all.ids) +# dashboard.list[[this.id]] <- make.ccd.table( +# this.id=this.id, +# HTTK.data.list=HTTK.data.list, +# species.list=SPECIES.LIST, +# model.list=MODELS.LIST, +# param.list=param.list, +# units.list=units.list, +# all.ids=all.ids, +# RANDOM.SEED=RANDOM.SEED, +# which.quantiles=WHICH.QUANTILES, +# num.samples=NUM.SAMPLES +# ) # Create a list with one table per chemical: dashboard.list <- clusterApply(cl, @@ -408,11 +409,11 @@ for (this.parameter in c( ivpkfit[ivpkfit.row,"Ref"] dashboard.table[dashboard.row,"Measured"] <- ivpkfit[ivpkfit.row, this.parameter] - } + } + } + } } } -} - # # @@ -559,9 +560,3 @@ write.table( quote=F, sep="\t") - - - - - - From e634904c5c999d7a403b16d76e1c4371f177680f Mon Sep 17 00:00:00 2001 From: Wambaugh Date: Wed, 24 Jan 2024 10:03:22 -0500 Subject: [PATCH 3/9] Split benchmark plots --- httk/R/benchmark_httk.R | 16 ++++++++++++++-- models/mod.RENAMEtoEXE | Bin 0 -> 677507 bytes scripts/Dashboard-HTTK-CssunitsmgpL-change.txt | 2 +- scripts/httk-for-dashboard.R | 4 ++-- 4 files changed, 17 insertions(+), 5 deletions(-) create mode 100644 models/mod.RENAMEtoEXE diff --git a/httk/R/benchmark_httk.R b/httk/R/benchmark_httk.R index 8e5aa26e..5531261d 100644 --- a/httk/R/benchmark_httk.R +++ b/httk/R/benchmark_httk.R @@ -617,8 +617,20 @@ benchmark_httk <- function( benchmarks[["units.plot"]] <- units.plot - rmsle.plot <- - ggplot2::ggplot(subset(plot.table, regexpr("RMSLE", Benchmark)!=-1), + model.rmsle.plot <- + ggplot2::ggplot(subset(plot.table, Benchmark %in% + c("RMSLE.wetmore","RMSLE.nomc")), + aes(x=Version, y=Value, color=Benchmark, group=Benchmark)) + + geom_point() + + geom_line() + + ylab("Root Mean Squared Log10 Error (RMSLE)") + + theme(axis.text.x = element_text(angle = 45, vjust = 0.5, hjust=1)) + benchmarks[["rmsle.plot"]] <- rmsle.plot + + invivo.rmsle.plot <- + ggplot2::ggplot(subset(plot.table, Benchmark %in% + c("InVivoCss","RMSLE.InVivoAUC", + "RMSLE.InVivoCmax","RMSLE.TissuePC")), aes(x=Version, y=Value, color=Benchmark, group=Benchmark)) + geom_point() + geom_line() + diff --git a/models/mod.RENAMEtoEXE b/models/mod.RENAMEtoEXE new file mode 100644 index 0000000000000000000000000000000000000000..487ea9dda6efaf47d6024d7ec3b2b6f59c784ac5 GIT binary 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z!5E`r{)4tlVq#`Du0SaozZX|b`(q4{;;nlE*iex@~cW_^G79)>9$7;qr{9O?qYG{j0E$Tmx0lN;#VDP zL~@m5daU7-T*3AB%N??8S8r~;Sw)KZq#NQA?hU2#hAf`fwIdrx z6J6t*uE)&Ty#n`PB^%2cq9wWQ-~!JsO8nF=(O}e?V238o)>YT7&Q;e?ts1Mp`ECGb9k>q=zlM;Q=yD>3;5WNX;wtlM WmYTH`znp9e>*eiX$yr{~i~c_%F_e7( literal 0 HcmV?d00001 diff --git a/scripts/Dashboard-HTTK-CssunitsmgpL-change.txt b/scripts/Dashboard-HTTK-CssunitsmgpL-change.txt index 8536a4fc..185784af 100644 --- a/scripts/Dashboard-HTTK-CssunitsmgpL-change.txt +++ b/scripts/Dashboard-HTTK-CssunitsmgpL-change.txt @@ -1,4 +1,4 @@ -DTXSID Parameter Model Species Percentile Predicted.prev Units.prev Predicted.new Units.new Change +DTXSID Parameter Model Species Percentile Predicted.new Units.new Predicted.prev Units.prev Change DTXSID001009966 Css 3compartmentss Human 95% 8.735 mg/L NA NA NA DTXSID001014436 Css 3compartmentss Human 95% 2.928 mg/L NA NA NA DTXSID00143784 Css 3compartmentss Human 95% 1.147 mg/L NA NA NA diff --git a/scripts/httk-for-dashboard.R b/scripts/httk-for-dashboard.R index 2d35e904..ef06c442 100644 --- a/scripts/httk-for-dashboard.R +++ b/scripts/httk-for-dashboard.R @@ -550,8 +550,8 @@ print(Fig) dev.off() tmp <- tmp[,colnames(tmp)[c(1:5,7:8,12:13,16)]] -colnames(tmp) <- gsub("x","prev",colnames(tmp)) -colnames(tmp) <- gsub("y","new",colnames(tmp)) +colnames(tmp) <- gsub("x","new",colnames(tmp)) +colnames(tmp) <- gsub("y","prev",colnames(tmp)) write.table( tmp, file=paste( From f6841529111bf3c72fad0bdfb01929b863a8b9ef Mon Sep 17 00:00:00 2001 From: Wambaugh Date: Fri, 2 Feb 2024 11:49:57 -0500 Subject: [PATCH 4/9] New predictions for CCD --- httk/vignettes/Crizer2023.Rmd | 701 ++++++++++++++++++++++++++++++++++ 1 file changed, 701 insertions(+) create mode 100644 httk/vignettes/Crizer2023.Rmd diff --git a/httk/vignettes/Crizer2023.Rmd b/httk/vignettes/Crizer2023.Rmd new file mode 100644 index 00000000..2adf5d85 --- /dev/null +++ b/httk/vignettes/Crizer2023.Rmd @@ -0,0 +1,701 @@ +--- +title: "Crizer et al. (2023): Analysis of PFAS Hepatic Clearance Data" +author: "David Crizer, Marci G. Smeltz, John F. Wambaugh, and Barbara A. Wetmore" +date: "`r Sys.Date()`" +output: rmarkdown::html_vignette +vignette: > + %\VignetteIndexEntry{Crizer (2023): PFAS Clearance} + %\VignetteEngine{knitr::rmarkdown} + %\VignetteEncoding{UTF-8} +--- + *Please send questions to wambaugh.john@epa.gov* + + from "Category-Based Toxicokinetic Evaluations of Data-Poor Per and Polyfluoroalkyl Substances (PFAS) by Gas Chromatography Coupled with Mass Spectrometry" + +Anna Kreutz, Matthew Scott Clifton, W. Matthew Henderson, Marci G. Smeltz, John F. Wambaugh, and Barbara A. Wetmore + +## Abstract + +Concern over per- and polyfluoroalkyl substances (PFAS) has increased significantly as more is learned about their widespread environmental presence, persistence, and bioaccumulative potential. The limited measurement, monitoring, toxicokinetic (TK), and toxicologic data currently available is inadequate to inform risk evaluations across this diverse domain. In this study, 73 PFAS were selected for *in vitro* TK evaluation to expand our knowledge across lesser studied PFAS that include alcohol, amide, and acrylate functional groups. Targeted analytical methods were developed using gas chromatography coupled with tandem mass spectrometry (GC-MS/MS); ultracentrifugation was used to measure human plasma protein binding and human hepatocyte suspensions were used in a substrate depletion approach to measure in vitro clearance (Clint). Method development was successful in plasma for 43 PFAS, with fraction unbound in plasma ($f_{up}$) values ranging from 0.004 for 1,6-dibromododecafluorohexane and 1 for 2-aminohexafluoropropan-2-ol, With a median $f_{up}$ of 0.09 (i.e., 91% bound), these PFAS are highly bound, but exhibit 10-fold lower binding than that recently reported for legacy perfluoroalkyl acids (Smeltz et al., 2022). Physico-chemical property trends analyses revealed that increased binding was associated with increases in mass, van der Waals volumes, and values of Log Pow and Log D at pH 7.4. Thirty of the PFAS evaluated in the hepatocyte assay showed abiotic loss, with many exceeding 60% loss within 60 min of media addition. Metabolic clearance was noted for 11 of the 13 successfully evaluated, with rates up to 49.9 l/min/million cells for 1H,1H,10H,10H-Perfluorodecane-1,10-diol. The Chemical Transformation Simulator revealed potential metabolites and other transformation products to consider during *in vitro* assay data interpretation. This integration of quantitative analytic methods with *in vitro* toxicokinetics has provided critical learnings as New Approach Methods are considered to evaluate PFAS for which volatility, metabolism, and other routes of transformation are likely to modulate their environmental fate. + +## HTTK Version + +This vignette was created with **httk** v2.3.0. Although we attempt to maintain +backward compatibility, if you encounter issues with the latest release of +**httk** + and cannot easily address the changes, historical versions of httk are +available from: https://cran.r-project.org/src/contrib/Archive/httk/ + + ## Prepare for session +```{r} +knitr::opts_chunk$set(collapse = TRUE, comment = '#>') +options(rmarkdown.html_vignette.check_title = FALSE) +``` + +### Load the relevant libraries +If you get the message "Error in library(X) : there is no package called 'X'" +then you will need to install that package: + + From the R command prompt: + + install.packages("X") + +Or, if using RStudio, look for 'Install Packages' under 'Tools' tab. + +```{r load_packages, eval = TRUE} +# Clear the memory: +rm(list=ls()) +# +# +# Setup +# +# +library(ggplot2) +library(httk) +library(grid) +library(scales) +library(viridis) +library(ggpubr) +library(readxl) + +LOC.WD <- "c:/users/jwambaug/" +``` + +Set the sizes of the labels and points in the figure (these settings impact the PNG differently than the figure within RStudio): +```{r fig_properties, eval = TRUE} +FONT.SIZE <- 18 +POINT.SIZE <- 3 +``` + +### Function to format scientific notation +From https://stackoverflow.com/questions/10762287/how-can-i-format-axis-labels-with-exponents-with-ggplot2-and-scales +```{R scientific.notation, eval = execute.vignette} +scientific_10 <- function(x) { + out <- gsub("1e", "10^", scientific_format()(x)) + out <- gsub("\\+","",out) + out <- gsub("10\\^01","10",out) + out <- parse(text=gsub("10\\^00","1",out)) +} +``` +# Analysis of Crizer et al. (2023) $Cl_{int}$ data + +## Remove Rat-specific HTTK data: +```{r removeoldhttk} +chem.physical_and_invitro.data$Rat.Clint <- NA +chem.physical_and_invitro.data$Rat.Funbound.plasma <- NA +``` + +```{r plot_clint_fup} +new.pfas <- get_2023pfasinfo(info="dtxsid", + model="3compartmentss2", + suppress.messages=TRUE) +clint.fup <- subset(chem.physical_and_invitro.data, + !is.na(Human.Funbound.plasma) & + !is.na(Human.Clint) & + (regexpr("PFAS",Chemical.Class)==-1 | + DTXSID %in% new.pfas)) +clint.fup$Human.Clint <- sapply(clint.fup$Human.Clint, + function(x) as.numeric(strsplit(x,",")[[1]][1])) +clint.fup$Human.Funbound.plasma <- sapply(clint.fup$Human.Funbound.plasma, + function(x) as.numeric(strsplit(x,",")[[1]][1])) +clint.fup[clint.fup$Chemical.Class=="","Chemical.Class"] <- "Non-PFAS" +clint.fup[clint.fup$Chemical.Class=="PFAS","Chemical.Class"] <- "Newly Measured PFAS" +``` + +```{r clint.fup.figures} +fig.clint.fup <- ggplot(data=clint.fup) + + geom_point(aes( + x=Human.Funbound.plasma, + y=Human.Clint, + colour=Chemical.Class, + shape=Chemical.Class), + size=POINT.SIZE) + + ylab(expression(italic("In Vitro")~"Measured Cl"[int]~"("*mu*"L/min/10"^'6'~"hepatocytes)")) + + xlab(expression(italic("In Vitro")~"Measured f"[up])) + + scale_x_log10(label=scientific_10)+ + scale_y_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE))+ + scale_color_viridis(discrete=2) + +print(fig.clint.fup) + +fig.fup.hist <- ggplot(data=clint.fup) + + geom_histogram(aes( + x=Human.Funbound.plasma, + colour=Chemical.Class, + fill=Chemical.Class)) + + xlab(expression(italic("In Vitro")~"Measured f"[up])) + + scale_x_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE))+ + scale_fill_viridis(discrete=2)+ + scale_color_viridis(discrete=2) + +print(fig.fup.hist) + +fig.clint.hist <- ggplot(data=clint.fup) + + geom_histogram(aes( + x=Human.Clint+10^-5, + colour=Chemical.Class, + fill=Chemical.Class)) + + xlab(expression(italic("In Vitro")~"Measured Cl"[int]~"("*mu*"L/min/10"^'6'~"hepatocytes)")) + + scale_x_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE))+ + scale_fill_viridis(discrete=2)+ + scale_color_viridis(discrete=2)+ + coord_flip() + +print(fig.clint.hist) + +fig.henry.hist <- ggplot(data=clint.fup) + + geom_histogram(aes( + x=10^logHenry, + colour=Chemical.Class, + fill=Chemical.Class)) + + xlab(expression("Henry's Law Constant (Atm.-m"^"3"*"/mole)")) + + scale_x_log10(label=scientific_10)+ + geom_vline(xintercept =10^-4.5,linetype="dashed",color="blue")+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE))+ + scale_fill_viridis(discrete=2)+ + scale_color_viridis(discrete=2) + +print(fig.henry.hist) +``` + +```{r multipanelnewclintfupdata} +ggarrange(fig.clint.fup, fig.clint.hist, fig.fup.hist, fig.henry.hist, + labels = c("A", "B", "C", "D"), + ncol = 2, nrow = 2, + common.legend = TRUE, legend = "bottom") +tiff(file = paste0(LOC.WD,"Fig_NewClintFup.tiff"), + height = 5*200, width = 5*200, compression = "lzw") +ggarrange(fig.clint.fup, fig.clint.hist, fig.fup.hist, fig.henry.hist, + labels = c("A", "B", "C", "D"), + ncol = 2, nrow = 2, + common.legend = TRUE, legend = "bottom") +dev.off() +``` + +## Compare against in vivo clearance data: +```{r invivoeval, eval=TRUE} +cl.table <- httk::pfas.clearance + +for (this.chem in unique(cl.table$DTXSID)) + if (this.chem %in% get_2023pfasinfo(info="dtxsid", + model="3compartmentss2", + suppress.messages=TRUE)) + { + chem.subset <- subset(cl.table, DTXSID==this.chem) + for (this.species in unique(cl.table$Species)) + { + # Css in units of mg/L for 1 mg/kg/day + out <- calc_analytic_css(dtxsid=this.chem, + species=this.species, + model="3compartmentss2", + output.units="mg/L", + parameterize.args=list(default.to.human=TRUE), + suppress.messages=TRUE) + if (any(cl.table$DTXSID==this.chem & + cl.table$Species==this.species)) + cl.table[cl.table$DTXSID==this.chem & + cl.table$Species==this.species, + "HTTK.Cltot.Lphpkgbw"] <- + 1/out/24 + else { + new.row <- cl.table[1,] + new.row[] <- NA + new.row[,"DTXSID"] <- this.chem + new.row[,"Species"] <- this.species + new.row[,"Sex"] <- "Female" + new.row[,"HTTK.Cltot.Lphpkgbw"] <- + 1/out/24 + cl.table <- rbind(cl.table,new.row) + new.row[,"Sex"] <- "Male" + cl.table <- rbind(cl.table,new.row) + } + } + } +``` + +```{r fig_clhttk, eval = TRUE} +fig.clhttk.invivo <- ggplot(data=cl.table) + + geom_point(aes( + x=HTTK.Cltot.Lphpkgbw, + y=ClLphpkgbw, + color=Species, + shape=Sex), + size=POINT.SIZE) + + geom_abline(slope=1,intercept=0,linetype="dashed")+ +# geom_line(aes(x=logP,y=logPfit1),color="black") + +# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + + ylab("In Vivo Clearance (L/h/kg bw)") + + xlab("HTTK Clearance (L/h/kg bw)") + + scale_x_log10(label=scientific_10)+ + scale_y_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE)) + +print(fig.clhttk.invivo) +``` +```{r fig_clspecies_invivo, eval = TRUE} +fig.clspecies.invivo <- ggplot(data=cl.table) + + geom_point(aes( + x=Species, + y=ClLphpkgbw, + color=Species, + shape=Sex), + size=POINT.SIZE) + + geom_line(aes(x=Species, + y=ClLphpkgbw, + group = DTXSID)) + +# geom_line(aes(x=logP,y=logPfit1),color="black") + +# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + + ylab("In Vivo Clearance (L/h/kg bw)") + + xlab("Species") + + scale_y_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE)) + +print(fig.clspecies.invivo) +``` + +```{r fig_clspecies_httk, eval = TRUE} +fig.clspecies.httk <- ggplot(data=cl.table) + + geom_point(aes( + x=Species, + y=HTTK.Cltot.Lphpkgbw, + color=Species, + shape=Sex), + size=POINT.SIZE) + +# geom_segment(color="#69b3a2", +# aes( +# x=Species, +# y=HTTK.Cltot.Lphpkgbw, +# xend = c(tail(Species, n = -1), NA), +# yend = c(tail(HTTK.Cltot.Lphpkgbw, n = -1), NA) +# ))+ +geom_line(aes(x=Species, + y=HTTK.Cltot.Lphpkgbw, + group = DTXSID)) + +ylab("HTTK Clearance (L/h/kg bw)") + + xlab("Species") + + scale_y_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE)) + +print(fig.clspecies.httk) +``` + + + +```{r invivoeval2, eval=TRUE} +for (this.chem in unique(cl.table$DTXSID)) + { + chem.subset <- subset(cl.table, DTXSID==this.chem) + for (this.species in unique(cl.table$Species)) + { + p <- try(parameterize_pfas1comp(dtxsid=this.chem, + species=this.species, + suppress.messages=TRUE)) + # Clearance in units of L/h/kgBW + if(!is(p, "try-error")) + cl.table[cl.table$DTXSID==this.chem & + cl.table$Species==this.species, + "MachineLearning.Cltot.Lphpkgbw"] <- p$kelim*p$Vd + } + } +``` + +```{r fig_clml, eval = TRUE} +fig.clml.invivo <- ggplot(data=cl.table) + + geom_jitter(aes( + x=MachineLearning.Cltot.Lphpkgbw, + y=ClLphpkgbw, + color=Species, + shape=Sex), + size=POINT.SIZE, + height=0,width=0.1) + + geom_abline(slope=1,intercept=0,linetype="dashed")+ +# geom_line(aes(x=logP,y=logPfit1),color="black") + +# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + + ylab("In Vivo Clearance (L/h/kg bw)") + + xlab("Machine Learning Clearance (L/h/kg bw)") + + scale_x_log10(label=scientific_10)+ + scale_y_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE)) + +print(fig.clml.invivo) +``` + +```{r multipanelrefchemdatafigureforpaper} +ggarrange(fig.clhttk.invivo, fig.clml.invivo, + labels = c("A", "B"), + ncol = 1, nrow = 2, + common.legend = TRUE, legend = "bottom") +tiff(file = paste0(LOC.WD,"Fig_PFASClearanceEval.tiff"), + height = 5*200, width = 3*200, compression = "lzw") +ggarrange(fig.clhttk.invivo, fig.clml.invivo, + labels = c("A", "B"), + ncol = 1, nrow = 2, + common.legend = TRUE, legend = "top") +dev.off() +``` + +```{r invivo_interspecies_eval_scaling, eval=TRUE} +cl.table <- as.data.frame(cl.table) +for (this.sex in c("Female","Male")) +{ + human.data <- subset(cl.table, Species=="Human" & + Sex==this.sex) + for (this.species in unique(cl.table$Species)) + if (this.species != "Human") + { + species.data <- subset(cl.table, Species==this.species & + Sex==this.sex) + for (this.chem in union(human.data$DTXSID, species.data$DTXSID)) + { + cl.table.index <- cl.table$Sex==this.sex & + cl.table$Species==this.species & + cl.table$DTXSID==this.chem + human.table.index <- human.data$Sex==this.sex & + human.data$DTXSID==this.chem + species.table.index <- species.data$Sex==this.sex & + species.data$DTXSID==this.chem + if (any(human.table.index) & any(species.table.index)) + { + cl.table[cl.table.index, "TK.Ratio.InVivo"] <- + species.data[species.table.index, "ClLphpkgbw"] / + human.data[human.table.index, "ClLphpkgbw"] + + cl.table[cl.table.index, "TK.Ratio.HTTK"] <- + species.data[species.table.index, "HTTK.Cltot.Lphpkgbw"] / + human.data[human.table.index, "HTTK.Cltot.Lphpkgbw"] + + cl.table[cl.table.index, "TK.Ratio.ML"] <- + species.data[species.table.index, "MachineLearning.Cltot.Lphpkgbw"] / + human.data[human.table.index, "MachineLearning.Cltot.Lphpkgbw"] + } + } + } +} +``` + +```{r cl_lit_Data} +huh.data <- as.data.frame(read_excel(paste0(LOC.WD,"Huh-2011-HumanCL.xlsx"))) +huh.data$Human.CL.Lphpkg <- as.numeric(huh.data[,4])*60/1000 +huh.data$Rat.CL.Lphpkg <- as.numeric(huh.data$a)*(0.25)^as.numeric(huh.data$b)*60/1000 + +httk.chem.list <- get_cheminfo(model="3compartmentss2", info="DTXSID") +for (this.chem in huh.data[,"DTXSID"]) + if (!is.na(this.chem)) + { + this.row <- which(huh.data[,"DTXSID"]==this.chem) + new.row <- cl.table[1,] + new.row[1,] <- NA + new.row[1, "DTXSID"] <- huh.data[this.row, "DTXSID"] + new.row[1, "Species"] <- "Rat" + new.row[1, "Sex"] <- "Female" + new.row[1, "ClLphpkgbw"] <- huh.data[this.row, "Human.CL.Lphpkg"] + + new.row[1, "TK.Ratio.InVivo"] <- huh.data[this.row, "Rat.CL.Lphpkg"] / + huh.data[this.row, "Human.CL.Lphpkg"] + if (this.chem %in% httk.chem.list) + { + print(this.chem) + human.css <- calc_analytic_css(dtxsid = this.chem, + model="3compartmentss2", + output.units="mg/L", + species="Human", + suppress.messages=TRUE) + new.row[1, "HTTK.Cltot.Lphpkgbw"] <- + 1/human.css/24 + rat.css <- calc_analytic_css(dtxsid = this.chem, + model="3compartmentss2", + output.units="mg/L", + species="Rat", + parameterize.args=list(default.to.human=TRUE), + suppress.messages=TRUE) + new.row[1, "TK.Ratio.HTTK"] <-human.css/rat.css + cl.table <- rbind(cl.table,new.row) + } + } +cl.table$Class <- "PFAS" +cl.table[!(cl.table$DTXSID %in% new.pfas), "Class"] <- "Other" +``` + +```{r fig_ratio_httk, eval = TRUE} +fig.ratio.httk <- ggplot(data=subset(cl.table, Species=="Rat")) + + geom_point(aes( + x=TK.Ratio.HTTK, + y=TK.Ratio.InVivo, + color=Class, + shape=Class), + size=POINT.SIZE) + + geom_abline(slope=1,intercept=0,linetype="dashed")+ +# geom_line(aes(x=logP,y=logPfit1),color="black") + +# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + + ylab("In Vivo Observed Clearance Ratio") + + xlab("HTTK Predicted Clearance Ratio") + + scale_x_log10(label=scientific_10)+ + scale_y_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE)) + + scale_color_viridis(discrete=2) + +print(fig.ratio.httk) + ggsave(paste0(LOC.WD, + "Fig_rat_cl_ratio.tiff"), + height =8, width =8, dpi = 600, compression = "lzw") +``` + +```{r fig_ratio_ml, eval = TRUE} +fig.ratio.ml <- ggplot(data=subset(cl.table, Species!="Human")) + + geom_point(aes( + x=TK.Ratio.ML, + y=TK.Ratio.InVivo, + color=Species, + shape=Sex), + size=POINT.SIZE) + + geom_abline(slope=1,intercept=0,linetype="dashed")+ +# geom_line(aes(x=logP,y=logPfit1),color="black") + +# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + + ylab("In Vivo Observed Clearance Ratio") + + xlab("Machine Learning Predicted Clearance Ratio") + + scale_x_log10(label=scientific_10)+ + scale_y_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE)) + +print(fig.ratio.ml) + ggsave(paste0(LOC.WD, + "Fig_ml_cl_ratio.tiff"), + height = 8, width = 8, dpi = 600, compression = "lzw") +``` + + +```{r multipanelrefchemdatafigureforpaper} +ggarrange(fig.ratio.httk, fig.ratio.ml, + labels = c("A", "B"), + ncol = 2, nrow = 1, + common.legend = TRUE, legend = "bottom") +tiff(file = paste0(LOC.WD,"Fig_PFASRatioEval.tiff"), + height = 3*200, width = 5*200, compression = "lzw") +ggarrange(fig.ratio.httk, fig.ratio.ml, + labels = c("A", "B"), + ncol = 2, nrow = 1, + common.legend = TRUE, legend = "top") +dev.off() +``` + +```{r firstpass, eval=TRUE} +firstpass.table <- NULL +for (this.chem in get_2023pfasinfo(info="dtxsid", suppress.messages=TRUE, + model="3compartmentss2")) +{ + params <- parameterize_steadystate(dtxsid=this.chem, + suppress.messages=TRUE) + params2 <- parameterize_schmitt(dtxsid=this.chem, + suppress.messages=TRUE) + ion <- calc_ionization( + pH=7.4, + pKa_Donor=params2[["pKa_Donor"]], + pKa_Accept=params2[["pKa_Accept"]]) + fraction_neutral <- ion$fraction_neutral + if (fraction_neutral < 0.5) params[['Rblood2plasma']] <- 0.5 + else params[['Rblood2plasma']] <- 20 + params[["Clmetabolismc"]] <- calc_hep_clearance(parameters=params, + hepatic.model='unscaled', + suppress.messages=TRUE)#L/h/kg body weight + this.row <- data.frame(DTXSID=this.chem, + Fsystemic=calc_hep_bioavailability( + parameters=params) + ) + firstpass.table <- rbind(firstpass.table, this.row) +} +``` + +```{r firstpass_fig, eval=TRUE} +fig.firstpass <- ggplot(data=firstpass.table) + + geom_histogram(aes( + x=Fsystemic),bins=10) + + ylab("Number of Chemicals") + + xlab("Fraction Systemically Available") + + theme_bw() + + theme( text = element_text(size=FONT.SIZE)) + +print(fig.firstpass) +``` + +# Evaluate Ratio Blood:Plasma Predictions +```{r rb2peval, eval=TRUE} +rb2p.table <- subset(chem.physical_and_invitro.data, + Human.Rblood2plasma.Reference %in% "Poothong 2017") +rb2p.table <- rb2p.table[,colnames(rb2p.table) %in% + c("Compound","DTXSID", + "Human.Rblood2plasma" + )] +for (this.chem in rb2p.table$DTXSID) +{ + if (this.chem %in% get_2023pfasinfo(info="dtxsid", suppress.messages=TRUE, + model="3compartmentss2")) + { + rb2p.table[rb2p.table$DTXSID==this.chem,"HTTK.Rb2p"] <- + calc_rblood2plasma(dtxsid=this.chem) + } + p <- try(parameterize_pfas1comp(dtxsid=this.chem)) + if(!is(p, "try-error")) + rb2p.table[rb2p.table$DTXSID==this.chem,"ML.Rb2p"] <- + p$Rblood2plasma +} +``` + +# Evaluate Membrane Affinity Predictions +```{r MAeval, eval=TRUE} +logma.table <- subset(chem.physical_and_invitro.data, + logMA.Reference %in% "Droge 2019") +logma.table <- logma.table[,colnames(logma.table) %in% + c("Compound","DTXSID", + "logMA" + )] +for (this.chem in logma.table$DTXSID) +{ + logma.table[logma.table$DTXSID==this.chem,"HTTK.logMA"] <- + signif(log10(calc_ma(dtxsid=this.chem, + pfas.calibration=FALSE)),3) +} +``` + +```{r fit_logma eval = TRUE} +fit.logma <- lm(logMA~HTTK.logMA,data=logma.table) +summary(fit.logma) + +logma.table$Fit.logMA <- signif(fit.logma$coefficients[1] + + fit.logma$coefficients[2]*logma.table$HTTK.logMA,3) +``` + +```{r fig_logma eval = TRUE} +fig.logma <- ggplot(data=logma.table) + + geom_point(aes( + x=HTTK.logMA, + y=logMA + ), + size=POINT.SIZE) + + geom_abline(slope=1,intercept=0,linetype="dashed")+ + geom_line(aes(x=HTTK.logMA, + y=Fit.logMA), color="red")+ + ylab("Droge (2019) logMA") + + xlab("HTTK log Membrane Affinity") + + scale_x_log10(label=scientific_10)+ + scale_y_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE)) + +print(fig.logma) +``` + +```{r rat_human_scaling} +half.lives <- NULL +for (this.chem in new.pfas) +{ + new.row <- data.frame(DTXSID=this.chem, + Human.HL=calc_half_life(dtxsid=this.chem,species="human"), + Rat.HL=calc_half_life(dtxsid=this.chem,species="rat", + default.to.human=TRUE)) + new.row$Type <- "HTTK" + half.lives <- rbind(half.lives, new.row) + param.human <- try(parameterize_pfas1comp(dtxsid=this.chem, + species="human", + suppress.messages=TRUE)) + param.rat <- try(parameterize_pfas1comp(dtxsid=this.chem, + species="rat", + suppress.messages=TRUE)) + if ("kelim" %in% names(param.human) & + "kelim" %in% names(param.rat)) + new.row <- data.frame(DTXSID=this.chem, + Human.HL=log(2)/param.human$kelim, + Rat.HL=log(2)/param.rat$kelim) + new.row$Type <- "ML" + half.lives <- rbind(half.lives, new.row) +} +half.lives$Ratio <- half.lives$Human.HL / half.lives$Rat.HL +``` + +```{r half_life_fig} +fig.species.scaling <- ggplot(data=half.lives) + + geom_histogram(aes( + x=Ratio, + colour=Type, + fill=Type), + bins=10) + + xlab("Human:Rat PK Half-Life Ratio") + + scale_x_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE))+ + scale_fill_viridis(discrete=2)+ + scale_color_viridis(discrete=2) + +print(fig.species.scaling) +``` + +```{r wallis_2023_halflives} +LOC.WD <- "c:/users/jwambaug/" +wallis <- as.data.frame(read_excel(paste0(LOC.WD,"Wallis-2023-PFASHL.xlsx"))) +wallis$HL.Low <- sapply(wallis[,4],function(x) as.numeric(strsplit(x,", ")[[1]][1])) +wallis$HL.High <- sapply(wallis[,4],function(x) as.numeric(strsplit(x,", ")[[1]][2])) +for (this.chem in wallis$DTXSID) +{ + param.human <- try(parameterize_pfas1comp(dtxsid=this.chem, + species="human", + suppress.messages=TRUE, + restrict.doa="none")) + if ("kelim" %in% names(param.human)) + wallis[wallis$DTXSID == this.chem, "HL.ML"] <- log(2)/param.human$kelim/24 +} +``` + +```{r results_from_new_model_run} +wallis[wallis$DTXSID=="DTXSID90723993","HL.ML"] <- 29000/24 +wallis[wallis$DTXSID=="DTXSID50723994","HL.ML"] <- 29000/24 +wallis[wallis$DTXSID=="DTXSID20892348","HL.ML"] <- 53/24 +for (this.col in c("HL.Low","HL.High")) +{ + new.col <- paste0(this.col,".Class") + wallis[, new.col] <- 4 + wallis[wallis[, this.col] < 60, + new.col] <- 3 + wallis[wallis[, this.col] < 7, + new.col] <- 2 + wallis[wallis[, this.col] < 0.5, + new.col] <- 1 +} +``` + +```{r wallis_2023_fig} +wallis$HL.ML.jitter <- wallis$HL.ML*(1.0+runif(dim(wallis)[1],-0.5,0.5)) + +wallis.fig <- ggplot(data=wallis) + + geom_segment(aes( + x=HL.ML.jitter, + xend=HL.ML.jitter, + y=HL.Low, + yend=HL.High, + colour=Status), + position = "jitter", + linewidth=2) + + geom_abline(slope=1,intercept=0,linetype="dashed")+ + xlab("Machine Learning Half-Life Prediction") + + ylab("Wallis et al. (2023) Estimate") + + scale_x_log10(label=scientific_10)+ + scale_y_log10(label=scientific_10)+ + theme_bw() + + theme( text = element_text(size=FONT.SIZE))+ + scale_color_viridis(discrete=2) + +print(wallis.fig) + +subset(wallis, is.na(HL.ML)) +``` \ No newline at end of file From b0ea9d4e59de634225ff46a4e5585c67d3833228 Mon Sep 17 00:00:00 2001 From: Wambaugh Date: Fri, 2 Feb 2024 11:54:10 -0500 Subject: [PATCH 5/9] New predictions for CCD --- httk/vignettes/Crizer2023.Rmd | 701 ---------------------------------- 1 file changed, 701 deletions(-) delete mode 100644 httk/vignettes/Crizer2023.Rmd diff --git a/httk/vignettes/Crizer2023.Rmd b/httk/vignettes/Crizer2023.Rmd deleted file mode 100644 index 2adf5d85..00000000 --- a/httk/vignettes/Crizer2023.Rmd +++ /dev/null @@ -1,701 +0,0 @@ ---- -title: "Crizer et al. (2023): Analysis of PFAS Hepatic Clearance Data" -author: "David Crizer, Marci G. Smeltz, John F. Wambaugh, and Barbara A. Wetmore" -date: "`r Sys.Date()`" -output: rmarkdown::html_vignette -vignette: > - %\VignetteIndexEntry{Crizer (2023): PFAS Clearance} - %\VignetteEngine{knitr::rmarkdown} - %\VignetteEncoding{UTF-8} ---- - *Please send questions to wambaugh.john@epa.gov* - - from "Category-Based Toxicokinetic Evaluations of Data-Poor Per and Polyfluoroalkyl Substances (PFAS) by Gas Chromatography Coupled with Mass Spectrometry" - -Anna Kreutz, Matthew Scott Clifton, W. Matthew Henderson, Marci G. Smeltz, John F. Wambaugh, and Barbara A. Wetmore - -## Abstract - -Concern over per- and polyfluoroalkyl substances (PFAS) has increased significantly as more is learned about their widespread environmental presence, persistence, and bioaccumulative potential. The limited measurement, monitoring, toxicokinetic (TK), and toxicologic data currently available is inadequate to inform risk evaluations across this diverse domain. In this study, 73 PFAS were selected for *in vitro* TK evaluation to expand our knowledge across lesser studied PFAS that include alcohol, amide, and acrylate functional groups. Targeted analytical methods were developed using gas chromatography coupled with tandem mass spectrometry (GC-MS/MS); ultracentrifugation was used to measure human plasma protein binding and human hepatocyte suspensions were used in a substrate depletion approach to measure in vitro clearance (Clint). Method development was successful in plasma for 43 PFAS, with fraction unbound in plasma ($f_{up}$) values ranging from 0.004 for 1,6-dibromododecafluorohexane and 1 for 2-aminohexafluoropropan-2-ol, With a median $f_{up}$ of 0.09 (i.e., 91% bound), these PFAS are highly bound, but exhibit 10-fold lower binding than that recently reported for legacy perfluoroalkyl acids (Smeltz et al., 2022). Physico-chemical property trends analyses revealed that increased binding was associated with increases in mass, van der Waals volumes, and values of Log Pow and Log D at pH 7.4. Thirty of the PFAS evaluated in the hepatocyte assay showed abiotic loss, with many exceeding 60% loss within 60 min of media addition. Metabolic clearance was noted for 11 of the 13 successfully evaluated, with rates up to 49.9 l/min/million cells for 1H,1H,10H,10H-Perfluorodecane-1,10-diol. The Chemical Transformation Simulator revealed potential metabolites and other transformation products to consider during *in vitro* assay data interpretation. This integration of quantitative analytic methods with *in vitro* toxicokinetics has provided critical learnings as New Approach Methods are considered to evaluate PFAS for which volatility, metabolism, and other routes of transformation are likely to modulate their environmental fate. - -## HTTK Version - -This vignette was created with **httk** v2.3.0. Although we attempt to maintain -backward compatibility, if you encounter issues with the latest release of -**httk** - and cannot easily address the changes, historical versions of httk are -available from: https://cran.r-project.org/src/contrib/Archive/httk/ - - ## Prepare for session -```{r} -knitr::opts_chunk$set(collapse = TRUE, comment = '#>') -options(rmarkdown.html_vignette.check_title = FALSE) -``` - -### Load the relevant libraries -If you get the message "Error in library(X) : there is no package called 'X'" -then you will need to install that package: - - From the R command prompt: - - install.packages("X") - -Or, if using RStudio, look for 'Install Packages' under 'Tools' tab. - -```{r load_packages, eval = TRUE} -# Clear the memory: -rm(list=ls()) -# -# -# Setup -# -# -library(ggplot2) -library(httk) -library(grid) -library(scales) -library(viridis) -library(ggpubr) -library(readxl) - -LOC.WD <- "c:/users/jwambaug/" -``` - -Set the sizes of the labels and points in the figure (these settings impact the PNG differently than the figure within RStudio): -```{r fig_properties, eval = TRUE} -FONT.SIZE <- 18 -POINT.SIZE <- 3 -``` - -### Function to format scientific notation -From https://stackoverflow.com/questions/10762287/how-can-i-format-axis-labels-with-exponents-with-ggplot2-and-scales -```{R scientific.notation, eval = execute.vignette} -scientific_10 <- function(x) { - out <- gsub("1e", "10^", scientific_format()(x)) - out <- gsub("\\+","",out) - out <- gsub("10\\^01","10",out) - out <- parse(text=gsub("10\\^00","1",out)) -} -``` -# Analysis of Crizer et al. (2023) $Cl_{int}$ data - -## Remove Rat-specific HTTK data: -```{r removeoldhttk} -chem.physical_and_invitro.data$Rat.Clint <- NA -chem.physical_and_invitro.data$Rat.Funbound.plasma <- NA -``` - -```{r plot_clint_fup} -new.pfas <- get_2023pfasinfo(info="dtxsid", - model="3compartmentss2", - suppress.messages=TRUE) -clint.fup <- subset(chem.physical_and_invitro.data, - !is.na(Human.Funbound.plasma) & - !is.na(Human.Clint) & - (regexpr("PFAS",Chemical.Class)==-1 | - DTXSID %in% new.pfas)) -clint.fup$Human.Clint <- sapply(clint.fup$Human.Clint, - function(x) as.numeric(strsplit(x,",")[[1]][1])) -clint.fup$Human.Funbound.plasma <- sapply(clint.fup$Human.Funbound.plasma, - function(x) as.numeric(strsplit(x,",")[[1]][1])) -clint.fup[clint.fup$Chemical.Class=="","Chemical.Class"] <- "Non-PFAS" -clint.fup[clint.fup$Chemical.Class=="PFAS","Chemical.Class"] <- "Newly Measured PFAS" -``` - -```{r clint.fup.figures} -fig.clint.fup <- ggplot(data=clint.fup) + - geom_point(aes( - x=Human.Funbound.plasma, - y=Human.Clint, - colour=Chemical.Class, - shape=Chemical.Class), - size=POINT.SIZE) + - ylab(expression(italic("In Vitro")~"Measured Cl"[int]~"("*mu*"L/min/10"^'6'~"hepatocytes)")) + - xlab(expression(italic("In Vitro")~"Measured f"[up])) + - scale_x_log10(label=scientific_10)+ - scale_y_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE))+ - scale_color_viridis(discrete=2) - -print(fig.clint.fup) - -fig.fup.hist <- ggplot(data=clint.fup) + - geom_histogram(aes( - x=Human.Funbound.plasma, - colour=Chemical.Class, - fill=Chemical.Class)) + - xlab(expression(italic("In Vitro")~"Measured f"[up])) + - scale_x_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE))+ - scale_fill_viridis(discrete=2)+ - scale_color_viridis(discrete=2) - -print(fig.fup.hist) - -fig.clint.hist <- ggplot(data=clint.fup) + - geom_histogram(aes( - x=Human.Clint+10^-5, - colour=Chemical.Class, - fill=Chemical.Class)) + - xlab(expression(italic("In Vitro")~"Measured Cl"[int]~"("*mu*"L/min/10"^'6'~"hepatocytes)")) + - scale_x_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE))+ - scale_fill_viridis(discrete=2)+ - scale_color_viridis(discrete=2)+ - coord_flip() - -print(fig.clint.hist) - -fig.henry.hist <- ggplot(data=clint.fup) + - geom_histogram(aes( - x=10^logHenry, - colour=Chemical.Class, - fill=Chemical.Class)) + - xlab(expression("Henry's Law Constant (Atm.-m"^"3"*"/mole)")) + - scale_x_log10(label=scientific_10)+ - geom_vline(xintercept =10^-4.5,linetype="dashed",color="blue")+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE))+ - scale_fill_viridis(discrete=2)+ - scale_color_viridis(discrete=2) - -print(fig.henry.hist) -``` - -```{r multipanelnewclintfupdata} -ggarrange(fig.clint.fup, fig.clint.hist, fig.fup.hist, fig.henry.hist, - labels = c("A", "B", "C", "D"), - ncol = 2, nrow = 2, - common.legend = TRUE, legend = "bottom") -tiff(file = paste0(LOC.WD,"Fig_NewClintFup.tiff"), - height = 5*200, width = 5*200, compression = "lzw") -ggarrange(fig.clint.fup, fig.clint.hist, fig.fup.hist, fig.henry.hist, - labels = c("A", "B", "C", "D"), - ncol = 2, nrow = 2, - common.legend = TRUE, legend = "bottom") -dev.off() -``` - -## Compare against in vivo clearance data: -```{r invivoeval, eval=TRUE} -cl.table <- httk::pfas.clearance - -for (this.chem in unique(cl.table$DTXSID)) - if (this.chem %in% get_2023pfasinfo(info="dtxsid", - model="3compartmentss2", - suppress.messages=TRUE)) - { - chem.subset <- subset(cl.table, DTXSID==this.chem) - for (this.species in unique(cl.table$Species)) - { - # Css in units of mg/L for 1 mg/kg/day - out <- calc_analytic_css(dtxsid=this.chem, - species=this.species, - model="3compartmentss2", - output.units="mg/L", - parameterize.args=list(default.to.human=TRUE), - suppress.messages=TRUE) - if (any(cl.table$DTXSID==this.chem & - cl.table$Species==this.species)) - cl.table[cl.table$DTXSID==this.chem & - cl.table$Species==this.species, - "HTTK.Cltot.Lphpkgbw"] <- - 1/out/24 - else { - new.row <- cl.table[1,] - new.row[] <- NA - new.row[,"DTXSID"] <- this.chem - new.row[,"Species"] <- this.species - new.row[,"Sex"] <- "Female" - new.row[,"HTTK.Cltot.Lphpkgbw"] <- - 1/out/24 - cl.table <- rbind(cl.table,new.row) - new.row[,"Sex"] <- "Male" - cl.table <- rbind(cl.table,new.row) - } - } - } -``` - -```{r fig_clhttk, eval = TRUE} -fig.clhttk.invivo <- ggplot(data=cl.table) + - geom_point(aes( - x=HTTK.Cltot.Lphpkgbw, - y=ClLphpkgbw, - color=Species, - shape=Sex), - size=POINT.SIZE) + - geom_abline(slope=1,intercept=0,linetype="dashed")+ -# geom_line(aes(x=logP,y=logPfit1),color="black") + -# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + - ylab("In Vivo Clearance (L/h/kg bw)") + - xlab("HTTK Clearance (L/h/kg bw)") + - scale_x_log10(label=scientific_10)+ - scale_y_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE)) - -print(fig.clhttk.invivo) -``` -```{r fig_clspecies_invivo, eval = TRUE} -fig.clspecies.invivo <- ggplot(data=cl.table) + - geom_point(aes( - x=Species, - y=ClLphpkgbw, - color=Species, - shape=Sex), - size=POINT.SIZE) + - geom_line(aes(x=Species, - y=ClLphpkgbw, - group = DTXSID)) + -# geom_line(aes(x=logP,y=logPfit1),color="black") + -# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + - ylab("In Vivo Clearance (L/h/kg bw)") + - xlab("Species") + - scale_y_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE)) - -print(fig.clspecies.invivo) -``` - -```{r fig_clspecies_httk, eval = TRUE} -fig.clspecies.httk <- ggplot(data=cl.table) + - geom_point(aes( - x=Species, - y=HTTK.Cltot.Lphpkgbw, - color=Species, - shape=Sex), - size=POINT.SIZE) + -# geom_segment(color="#69b3a2", -# aes( -# x=Species, -# y=HTTK.Cltot.Lphpkgbw, -# xend = c(tail(Species, n = -1), NA), -# yend = c(tail(HTTK.Cltot.Lphpkgbw, n = -1), NA) -# ))+ -geom_line(aes(x=Species, - y=HTTK.Cltot.Lphpkgbw, - group = DTXSID)) + -ylab("HTTK Clearance (L/h/kg bw)") + - xlab("Species") + - scale_y_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE)) - -print(fig.clspecies.httk) -``` - - - -```{r invivoeval2, eval=TRUE} -for (this.chem in unique(cl.table$DTXSID)) - { - chem.subset <- subset(cl.table, DTXSID==this.chem) - for (this.species in unique(cl.table$Species)) - { - p <- try(parameterize_pfas1comp(dtxsid=this.chem, - species=this.species, - suppress.messages=TRUE)) - # Clearance in units of L/h/kgBW - if(!is(p, "try-error")) - cl.table[cl.table$DTXSID==this.chem & - cl.table$Species==this.species, - "MachineLearning.Cltot.Lphpkgbw"] <- p$kelim*p$Vd - } - } -``` - -```{r fig_clml, eval = TRUE} -fig.clml.invivo <- ggplot(data=cl.table) + - geom_jitter(aes( - x=MachineLearning.Cltot.Lphpkgbw, - y=ClLphpkgbw, - color=Species, - shape=Sex), - size=POINT.SIZE, - height=0,width=0.1) + - geom_abline(slope=1,intercept=0,linetype="dashed")+ -# geom_line(aes(x=logP,y=logPfit1),color="black") + -# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + - ylab("In Vivo Clearance (L/h/kg bw)") + - xlab("Machine Learning Clearance (L/h/kg bw)") + - scale_x_log10(label=scientific_10)+ - scale_y_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE)) - -print(fig.clml.invivo) -``` - -```{r multipanelrefchemdatafigureforpaper} -ggarrange(fig.clhttk.invivo, fig.clml.invivo, - labels = c("A", "B"), - ncol = 1, nrow = 2, - common.legend = TRUE, legend = "bottom") -tiff(file = paste0(LOC.WD,"Fig_PFASClearanceEval.tiff"), - height = 5*200, width = 3*200, compression = "lzw") -ggarrange(fig.clhttk.invivo, fig.clml.invivo, - labels = c("A", "B"), - ncol = 1, nrow = 2, - common.legend = TRUE, legend = "top") -dev.off() -``` - -```{r invivo_interspecies_eval_scaling, eval=TRUE} -cl.table <- as.data.frame(cl.table) -for (this.sex in c("Female","Male")) -{ - human.data <- subset(cl.table, Species=="Human" & - Sex==this.sex) - for (this.species in unique(cl.table$Species)) - if (this.species != "Human") - { - species.data <- subset(cl.table, Species==this.species & - Sex==this.sex) - for (this.chem in union(human.data$DTXSID, species.data$DTXSID)) - { - cl.table.index <- cl.table$Sex==this.sex & - cl.table$Species==this.species & - cl.table$DTXSID==this.chem - human.table.index <- human.data$Sex==this.sex & - human.data$DTXSID==this.chem - species.table.index <- species.data$Sex==this.sex & - species.data$DTXSID==this.chem - if (any(human.table.index) & any(species.table.index)) - { - cl.table[cl.table.index, "TK.Ratio.InVivo"] <- - species.data[species.table.index, "ClLphpkgbw"] / - human.data[human.table.index, "ClLphpkgbw"] - - cl.table[cl.table.index, "TK.Ratio.HTTK"] <- - species.data[species.table.index, "HTTK.Cltot.Lphpkgbw"] / - human.data[human.table.index, "HTTK.Cltot.Lphpkgbw"] - - cl.table[cl.table.index, "TK.Ratio.ML"] <- - species.data[species.table.index, "MachineLearning.Cltot.Lphpkgbw"] / - human.data[human.table.index, "MachineLearning.Cltot.Lphpkgbw"] - } - } - } -} -``` - -```{r cl_lit_Data} -huh.data <- as.data.frame(read_excel(paste0(LOC.WD,"Huh-2011-HumanCL.xlsx"))) -huh.data$Human.CL.Lphpkg <- as.numeric(huh.data[,4])*60/1000 -huh.data$Rat.CL.Lphpkg <- as.numeric(huh.data$a)*(0.25)^as.numeric(huh.data$b)*60/1000 - -httk.chem.list <- get_cheminfo(model="3compartmentss2", info="DTXSID") -for (this.chem in huh.data[,"DTXSID"]) - if (!is.na(this.chem)) - { - this.row <- which(huh.data[,"DTXSID"]==this.chem) - new.row <- cl.table[1,] - new.row[1,] <- NA - new.row[1, "DTXSID"] <- huh.data[this.row, "DTXSID"] - new.row[1, "Species"] <- "Rat" - new.row[1, "Sex"] <- "Female" - new.row[1, "ClLphpkgbw"] <- huh.data[this.row, "Human.CL.Lphpkg"] - - new.row[1, "TK.Ratio.InVivo"] <- huh.data[this.row, "Rat.CL.Lphpkg"] / - huh.data[this.row, "Human.CL.Lphpkg"] - if (this.chem %in% httk.chem.list) - { - print(this.chem) - human.css <- calc_analytic_css(dtxsid = this.chem, - model="3compartmentss2", - output.units="mg/L", - species="Human", - suppress.messages=TRUE) - new.row[1, "HTTK.Cltot.Lphpkgbw"] <- - 1/human.css/24 - rat.css <- calc_analytic_css(dtxsid = this.chem, - model="3compartmentss2", - output.units="mg/L", - species="Rat", - parameterize.args=list(default.to.human=TRUE), - suppress.messages=TRUE) - new.row[1, "TK.Ratio.HTTK"] <-human.css/rat.css - cl.table <- rbind(cl.table,new.row) - } - } -cl.table$Class <- "PFAS" -cl.table[!(cl.table$DTXSID %in% new.pfas), "Class"] <- "Other" -``` - -```{r fig_ratio_httk, eval = TRUE} -fig.ratio.httk <- ggplot(data=subset(cl.table, Species=="Rat")) + - geom_point(aes( - x=TK.Ratio.HTTK, - y=TK.Ratio.InVivo, - color=Class, - shape=Class), - size=POINT.SIZE) + - geom_abline(slope=1,intercept=0,linetype="dashed")+ -# geom_line(aes(x=logP,y=logPfit1),color="black") + -# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + - ylab("In Vivo Observed Clearance Ratio") + - xlab("HTTK Predicted Clearance Ratio") + - scale_x_log10(label=scientific_10)+ - scale_y_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE)) + - scale_color_viridis(discrete=2) - -print(fig.ratio.httk) - ggsave(paste0(LOC.WD, - "Fig_rat_cl_ratio.tiff"), - height =8, width =8, dpi = 600, compression = "lzw") -``` - -```{r fig_ratio_ml, eval = TRUE} -fig.ratio.ml <- ggplot(data=subset(cl.table, Species!="Human")) + - geom_point(aes( - x=TK.Ratio.ML, - y=TK.Ratio.InVivo, - color=Species, - shape=Sex), - size=POINT.SIZE) + - geom_abline(slope=1,intercept=0,linetype="dashed")+ -# geom_line(aes(x=logP,y=logPfit1),color="black") + -# geom_line(aes(x=logP,y=logPfit2),color="blue",linetype = "dashed") + - ylab("In Vivo Observed Clearance Ratio") + - xlab("Machine Learning Predicted Clearance Ratio") + - scale_x_log10(label=scientific_10)+ - scale_y_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE)) - -print(fig.ratio.ml) - ggsave(paste0(LOC.WD, - "Fig_ml_cl_ratio.tiff"), - height = 8, width = 8, dpi = 600, compression = "lzw") -``` - - -```{r multipanelrefchemdatafigureforpaper} -ggarrange(fig.ratio.httk, fig.ratio.ml, - labels = c("A", "B"), - ncol = 2, nrow = 1, - common.legend = TRUE, legend = "bottom") -tiff(file = paste0(LOC.WD,"Fig_PFASRatioEval.tiff"), - height = 3*200, width = 5*200, compression = "lzw") -ggarrange(fig.ratio.httk, fig.ratio.ml, - labels = c("A", "B"), - ncol = 2, nrow = 1, - common.legend = TRUE, legend = "top") -dev.off() -``` - -```{r firstpass, eval=TRUE} -firstpass.table <- NULL -for (this.chem in get_2023pfasinfo(info="dtxsid", suppress.messages=TRUE, - model="3compartmentss2")) -{ - params <- parameterize_steadystate(dtxsid=this.chem, - suppress.messages=TRUE) - params2 <- parameterize_schmitt(dtxsid=this.chem, - suppress.messages=TRUE) - ion <- calc_ionization( - pH=7.4, - pKa_Donor=params2[["pKa_Donor"]], - pKa_Accept=params2[["pKa_Accept"]]) - fraction_neutral <- ion$fraction_neutral - if (fraction_neutral < 0.5) params[['Rblood2plasma']] <- 0.5 - else params[['Rblood2plasma']] <- 20 - params[["Clmetabolismc"]] <- calc_hep_clearance(parameters=params, - hepatic.model='unscaled', - suppress.messages=TRUE)#L/h/kg body weight - this.row <- data.frame(DTXSID=this.chem, - Fsystemic=calc_hep_bioavailability( - parameters=params) - ) - firstpass.table <- rbind(firstpass.table, this.row) -} -``` - -```{r firstpass_fig, eval=TRUE} -fig.firstpass <- ggplot(data=firstpass.table) + - geom_histogram(aes( - x=Fsystemic),bins=10) + - ylab("Number of Chemicals") + - xlab("Fraction Systemically Available") + - theme_bw() + - theme( text = element_text(size=FONT.SIZE)) - -print(fig.firstpass) -``` - -# Evaluate Ratio Blood:Plasma Predictions -```{r rb2peval, eval=TRUE} -rb2p.table <- subset(chem.physical_and_invitro.data, - Human.Rblood2plasma.Reference %in% "Poothong 2017") -rb2p.table <- rb2p.table[,colnames(rb2p.table) %in% - c("Compound","DTXSID", - "Human.Rblood2plasma" - )] -for (this.chem in rb2p.table$DTXSID) -{ - if (this.chem %in% get_2023pfasinfo(info="dtxsid", suppress.messages=TRUE, - model="3compartmentss2")) - { - rb2p.table[rb2p.table$DTXSID==this.chem,"HTTK.Rb2p"] <- - calc_rblood2plasma(dtxsid=this.chem) - } - p <- try(parameterize_pfas1comp(dtxsid=this.chem)) - if(!is(p, "try-error")) - rb2p.table[rb2p.table$DTXSID==this.chem,"ML.Rb2p"] <- - p$Rblood2plasma -} -``` - -# Evaluate Membrane Affinity Predictions -```{r MAeval, eval=TRUE} -logma.table <- subset(chem.physical_and_invitro.data, - logMA.Reference %in% "Droge 2019") -logma.table <- logma.table[,colnames(logma.table) %in% - c("Compound","DTXSID", - "logMA" - )] -for (this.chem in logma.table$DTXSID) -{ - logma.table[logma.table$DTXSID==this.chem,"HTTK.logMA"] <- - signif(log10(calc_ma(dtxsid=this.chem, - pfas.calibration=FALSE)),3) -} -``` - -```{r fit_logma eval = TRUE} -fit.logma <- lm(logMA~HTTK.logMA,data=logma.table) -summary(fit.logma) - -logma.table$Fit.logMA <- signif(fit.logma$coefficients[1] + - fit.logma$coefficients[2]*logma.table$HTTK.logMA,3) -``` - -```{r fig_logma eval = TRUE} -fig.logma <- ggplot(data=logma.table) + - geom_point(aes( - x=HTTK.logMA, - y=logMA - ), - size=POINT.SIZE) + - geom_abline(slope=1,intercept=0,linetype="dashed")+ - geom_line(aes(x=HTTK.logMA, - y=Fit.logMA), color="red")+ - ylab("Droge (2019) logMA") + - xlab("HTTK log Membrane Affinity") + - scale_x_log10(label=scientific_10)+ - scale_y_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE)) - -print(fig.logma) -``` - -```{r rat_human_scaling} -half.lives <- NULL -for (this.chem in new.pfas) -{ - new.row <- data.frame(DTXSID=this.chem, - Human.HL=calc_half_life(dtxsid=this.chem,species="human"), - Rat.HL=calc_half_life(dtxsid=this.chem,species="rat", - default.to.human=TRUE)) - new.row$Type <- "HTTK" - half.lives <- rbind(half.lives, new.row) - param.human <- try(parameterize_pfas1comp(dtxsid=this.chem, - species="human", - suppress.messages=TRUE)) - param.rat <- try(parameterize_pfas1comp(dtxsid=this.chem, - species="rat", - suppress.messages=TRUE)) - if ("kelim" %in% names(param.human) & - "kelim" %in% names(param.rat)) - new.row <- data.frame(DTXSID=this.chem, - Human.HL=log(2)/param.human$kelim, - Rat.HL=log(2)/param.rat$kelim) - new.row$Type <- "ML" - half.lives <- rbind(half.lives, new.row) -} -half.lives$Ratio <- half.lives$Human.HL / half.lives$Rat.HL -``` - -```{r half_life_fig} -fig.species.scaling <- ggplot(data=half.lives) + - geom_histogram(aes( - x=Ratio, - colour=Type, - fill=Type), - bins=10) + - xlab("Human:Rat PK Half-Life Ratio") + - scale_x_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE))+ - scale_fill_viridis(discrete=2)+ - scale_color_viridis(discrete=2) - -print(fig.species.scaling) -``` - -```{r wallis_2023_halflives} -LOC.WD <- "c:/users/jwambaug/" -wallis <- as.data.frame(read_excel(paste0(LOC.WD,"Wallis-2023-PFASHL.xlsx"))) -wallis$HL.Low <- sapply(wallis[,4],function(x) as.numeric(strsplit(x,", ")[[1]][1])) -wallis$HL.High <- sapply(wallis[,4],function(x) as.numeric(strsplit(x,", ")[[1]][2])) -for (this.chem in wallis$DTXSID) -{ - param.human <- try(parameterize_pfas1comp(dtxsid=this.chem, - species="human", - suppress.messages=TRUE, - restrict.doa="none")) - if ("kelim" %in% names(param.human)) - wallis[wallis$DTXSID == this.chem, "HL.ML"] <- log(2)/param.human$kelim/24 -} -``` - -```{r results_from_new_model_run} -wallis[wallis$DTXSID=="DTXSID90723993","HL.ML"] <- 29000/24 -wallis[wallis$DTXSID=="DTXSID50723994","HL.ML"] <- 29000/24 -wallis[wallis$DTXSID=="DTXSID20892348","HL.ML"] <- 53/24 -for (this.col in c("HL.Low","HL.High")) -{ - new.col <- paste0(this.col,".Class") - wallis[, new.col] <- 4 - wallis[wallis[, this.col] < 60, - new.col] <- 3 - wallis[wallis[, this.col] < 7, - new.col] <- 2 - wallis[wallis[, this.col] < 0.5, - new.col] <- 1 -} -``` - -```{r wallis_2023_fig} -wallis$HL.ML.jitter <- wallis$HL.ML*(1.0+runif(dim(wallis)[1],-0.5,0.5)) - -wallis.fig <- ggplot(data=wallis) + - geom_segment(aes( - x=HL.ML.jitter, - xend=HL.ML.jitter, - y=HL.Low, - yend=HL.High, - colour=Status), - position = "jitter", - linewidth=2) + - geom_abline(slope=1,intercept=0,linetype="dashed")+ - xlab("Machine Learning Half-Life Prediction") + - ylab("Wallis et al. (2023) Estimate") + - scale_x_log10(label=scientific_10)+ - scale_y_log10(label=scientific_10)+ - theme_bw() + - theme( text = element_text(size=FONT.SIZE))+ - scale_color_viridis(discrete=2) - -print(wallis.fig) - -subset(wallis, is.na(HL.ML)) -``` \ No newline at end of file From 6f3687e6d1ad5d01eac58897fbbe2659eae661f0 Mon Sep 17 00:00:00 2001 From: Wambaugh Date: Tue, 6 Feb 2024 07:58:06 -0500 Subject: [PATCH 6/9] Correctly split RMSLE figures --- httk/R/benchmark_httk.R | 19 +++++++++++++------ 1 file changed, 13 insertions(+), 6 deletions(-) diff --git a/httk/R/benchmark_httk.R b/httk/R/benchmark_httk.R index 5531261d..3227800b 100644 --- a/httk/R/benchmark_httk.R +++ b/httk/R/benchmark_httk.R @@ -104,7 +104,14 @@ #' calculated. If the units are correct the ratio should be 1 (within the #' precision of the functions -- usually four significant figures). \cr #' -#' rmsle.plot \tab A ggplot2 figure showing RMSLE tests of various functions. +#' invivo.rmsle.plot \tab A ggplot2 figure comparing +#' model predictions to in vivo measured values. +#' Output generated is the root mean square log10 error for parameters estimated +#' by the package. \cr +#' +#' model.rmsle.plot \tab A ggplot2 figure comparing various functions values +#' against values predicted by other models (chiefly SimCyp predictions from +#' Wetmoer et al. 2012 and 2015. #' Output generated is the root mean square log10 error for parameters estimated #' by the package. \cr #' @@ -616,27 +623,27 @@ benchmark_httk <- function( theme(axis.text.x = element_text(angle = 45, vjust = 0.5, hjust=1)) benchmarks[["units.plot"]] <- units.plot - + browser() model.rmsle.plot <- ggplot2::ggplot(subset(plot.table, Benchmark %in% - c("RMSLE.wetmore","RMSLE.nomc")), + c("RMSLE.Wetmore","RMSLE.noMC")), aes(x=Version, y=Value, color=Benchmark, group=Benchmark)) + geom_point() + geom_line() + ylab("Root Mean Squared Log10 Error (RMSLE)") + theme(axis.text.x = element_text(angle = 45, vjust = 0.5, hjust=1)) - benchmarks[["rmsle.plot"]] <- rmsle.plot + benchmarks[["model.rmsle.plot"]] <- model.rmsle.plot invivo.rmsle.plot <- ggplot2::ggplot(subset(plot.table, Benchmark %in% - c("InVivoCss","RMSLE.InVivoAUC", + c("RMSLE.InVivoCss","RMSLE.InVivoAUC", "RMSLE.InVivoCmax","RMSLE.TissuePC")), aes(x=Version, y=Value, color=Benchmark, group=Benchmark)) + geom_point() + geom_line() + ylab("Root Mean Squared Log10 Error (RMSLE)") + theme(axis.text.x = element_text(angle = 45, vjust = 0.5, hjust=1)) - benchmarks[["rmsle.plot"]] <- rmsle.plot + benchmarks[["invivo.rmsle.plot"]] <- invivo.rmsle.plot count.plot <- ggplot2::ggplot(subset(plot.table, regexpr("N.", Benchmark)!=-1), From 1ba45f7b0c6d2005d82cf786f7c1f2af7437ea52 Mon Sep 17 00:00:00 2001 From: Wambaugh Date: Tue, 6 Feb 2024 10:01:50 -0500 Subject: [PATCH 7/9] Cleaned up dashboard script --- httk/R/benchmark_httk.R | 8 -- scripts/httk-for-dashboard.R | 142 ++++++++++++++++++++--------------- 2 files changed, 81 insertions(+), 69 deletions(-) diff --git a/httk/R/benchmark_httk.R b/httk/R/benchmark_httk.R index 3227800b..097b1fac 100644 --- a/httk/R/benchmark_httk.R +++ b/httk/R/benchmark_httk.R @@ -430,13 +430,6 @@ benchmark_httk <- function( as.numeric(FitData2$Pred.Cmax) / as.numeric(FitData2$Cmax))) ) - -# write.table(FitData[,c(1,3,5,6,29,31)], -# file=paste("invivovcsscheck-", -# packageVersion("httk"), -# ".txt",sep=""), -# row.names=FALSE, -# sep="\t") } # @@ -623,7 +616,6 @@ benchmark_httk <- function( theme(axis.text.x = element_text(angle = 45, vjust = 0.5, hjust=1)) benchmarks[["units.plot"]] <- units.plot - browser() model.rmsle.plot <- ggplot2::ggplot(subset(plot.table, Benchmark %in% c("RMSLE.Wetmore","RMSLE.noMC")), diff --git a/scripts/httk-for-dashboard.R b/scripts/httk-for-dashboard.R index ef06c442..bb5174a4 100644 --- a/scripts/httk-for-dashboard.R +++ b/scripts/httk-for-dashboard.R @@ -1,3 +1,5 @@ +#R CMD BATCH --vanilla httk-for-dashboard.R + library(httk) library(parallel) library(data.table) @@ -44,24 +46,30 @@ load_pradeep2020() load_honda2023() # Find all the duplicates: +# First eliminat NA DTXSIDs (can't do logical tests on them) chem.physical_and_invitro.data <- subset(chem.physical_and_invitro.data, !is.na(DTXSID)) -dup.chems <- chem.physical_and_invitro.data$DTXSID[duplicated((chem.physical_and_invitro.data$DTXSID))] +# Now check for duplicated DTXSIDs: +dup.chems <- chem.physical_and_invitro.data$DTXSID[ + duplicated((chem.physical_and_invitro.data$DTXSID))] length(dup.chems) +# Now check for duplicated CASRN and grab the DTXSIDs of any chemicals with +# duplicated CAS (but unique DTXSIDs): dup.chems <- unique(dup.chems, subset(chem.physical_and_invitro.data, CAS %in% chem.physical_and_invitro.data$CAS[ duplicated((chem.physical_and_invitro.data$CAS))])$DTXSID) length(dup.chems) -# Try to keep predictions from Dawson 2021: +# Among the duplicates, try to keep the predictions from Dawson 2021: for (this.chem in dup.chems) { these.dup.rows <- which(chem.physical_and_invitro.data$DTXSID==this.chem) keep.row <- NULL for(this.row in these.dup.rows) if (regexpr("Dawson", - chem.physical_and_invitro.data[this.row,"Human.Clint.Reference"])!=-1 + chem.physical_and_invitro.data[this.row, + "Human.Clint.Reference"])!=-1 ) keep.row <- this.row these.dup.rows <- these.dup.rows[these.dup.rows!=keep.row] chem.physical_and_invitro.data <- chem.physical_and_invitro.data[ @@ -71,13 +79,16 @@ for (this.chem in dup.chems) # Check to make sure no duplicates left: chem.physical_and_invitro.data <- subset(chem.physical_and_invitro.data, !is.na(DTXSID)) -dup.chems <- chem.physical_and_invitro.data$DTXSID[duplicated((chem.physical_and_invitro.data$DTXSID))] +dup.chems <- chem.physical_and_invitro.data$DTXSID[ + duplicated((chem.physical_and_invitro.data$DTXSID))] length(dup.chems) dup.chems <- unique(dup.chems, subset(chem.physical_and_invitro.data, CAS %in% - chem.physical_and_invitro.data$CAS[ - duplicated((chem.physical_and_invitro.data$CAS))])$DTXSID) -length(dup.chems) + chem.physical_and_invitro.data$CAS[ + duplicated((chem.physical_and_invitro.data$CAS))])$DTXSID) +# This should be true: +length(dup.chems) == 0 + # Organize HTTK data by species: HTTK.data.list <- list() @@ -98,12 +109,6 @@ for (this.species in SPECIES.LIST) all.ids <- sort(unique(c(all.ids,HTTK.data.list[[this.species]]$DTXSID))) } -# temporarily make it run fast: -#ivpkfit <- read.csv("invivoPKfit-params.for.dashboard.txt") -#short.list <- ivpkfit$Chemical[1:25] -#all.ids <- all.ids[all.ids %in% short.list] - - # We want one parameter per line, but the code is pretty different wrt how we # retrieve/calculate these values: param.list <- c("Clint","Fup","Vd","Days.Css","TK.Half.Life","Css") @@ -115,8 +120,6 @@ units.list[["Days.Css"]] <- "Days" units.list[["TK.Half.Life"]] <- "hours" units.list[["Css"]] <- "mg/L" - - # Function to create all the rows of info for a particular chemical: make.ccd.table <- function( this.id, @@ -274,51 +277,13 @@ make.ccd.table <- function( return(dashboard.table) } -# Create a multicore cluster: -cl <- parallel::makeCluster(NUM.CPU) - -# Load httk on all cores: -clusterEvalQ(cl, library(httk)) -# Clear memory all cores: -clusterEvalQ(cl, rm(list=ls())) - -# Define the table creator function on all cores: -clusterExport(cl, "make.ccd.table") -# Share data with all cores: -clusterExport(cl, c( - "chem.physical_and_invitro.data", - "HTTK.data.list", - "SPECIES.LIST", - "MODELS.LIST", - "param.list", - "units.list", - "all.ids", - "RANDOM.SEED", - "WHICH.QUANTILES", - "NUM.SAMPLES")) - +if (NUM.CPU == 1) +{ # Non-parallel version: -# dashboard.list <- NULL -# for (this.id in all.ids) -# dashboard.list[[this.id]] <- make.ccd.table( -# this.id=this.id, -# HTTK.data.list=HTTK.data.list, -# species.list=SPECIES.LIST, -# model.list=MODELS.LIST, -# param.list=param.list, -# units.list=units.list, -# all.ids=all.ids, -# RANDOM.SEED=RANDOM.SEED, -# which.quantiles=WHICH.QUANTILES, -# num.samples=NUM.SAMPLES -# ) - -# Create a list with one table per chemical: -dashboard.list <- clusterApply(cl, - all.ids, - function(x) - make.ccd.table( - this.id=x, +dashboard.list <- NULL +for (this.id in all.ids) + dashboard.list[[this.id]] <- make.ccd.table( + this.id=this.id, HTTK.data.list=HTTK.data.list, species.list=SPECIES.LIST, model.list=MODELS.LIST, @@ -328,9 +293,60 @@ dashboard.list <- clusterApply(cl, RANDOM.SEED=RANDOM.SEED, which.quantiles=WHICH.QUANTILES, num.samples=NUM.SAMPLES - )) + ) +} else { + # Create a multicore cluster: + cl <- parallel::makeCluster(NUM.CPU) + + # Load httk on all cores: + clusterEvalQ(cl, library(httk)) + # Clear memory all cores: + clusterEvalQ(cl, rm(list=ls())) + + # Dawson 2021: + clusterEvalQ(cl, load_dawson2021()) + # ADmet Predictor: + clusterEvalQ(cl, load_sipes2017()) + # Machine learning model: + clusterEvalQ(cl, load_pradeep2020()) + # Caco-2 QSPR: + clusterEvalQ(cl, load_honda2023()) + + # Define the table creator function on all cores: + clusterExport(cl, "make.ccd.table") + # Share data with all cores: + clusterExport(cl, c( + "chem.physical_and_invitro.data", + "HTTK.data.list", + "SPECIES.LIST", + "MODELS.LIST", + "param.list", + "units.list", + "all.ids", + "RANDOM.SEED", + "WHICH.QUANTILES", + "NUM.SAMPLES")) + + # Create a list with one table per chemical: + dashboard.list <- clusterApply(cl, + all.ids, + function(x) + make.ccd.table( + this.id=x, + HTTK.data.list=HTTK.data.list, + species.list=SPECIES.LIST, + model.list=MODELS.LIST, + param.list=param.list, + units.list=units.list, + all.ids=all.ids, + RANDOM.SEED=RANDOM.SEED, + which.quantiles=WHICH.QUANTILES, + num.samples=NUM.SAMPLES + )) + + stopCluster(cl) +} -stopCluster(cl) # Combine all the individual tables into a single table: dashboard.table <- rbindlist(dashboard.list) @@ -549,6 +565,8 @@ png("calc-mc-css-fold-change.png") print(Fig) dev.off() +# Duplicate column names in the two merged tables (dashboard.table, prev.table) +# have .x and .y assigned to them respectively. tmp <- tmp[,colnames(tmp)[c(1:5,7:8,12:13,16)]] colnames(tmp) <- gsub("x","new",colnames(tmp)) colnames(tmp) <- gsub("y","prev",colnames(tmp)) @@ -559,4 +577,6 @@ write.table( row.names=F, quote=F, sep="\t") + +sessionInfo() From 2a2687dc7d66ad3f4028922a3b2b6e60fbc668fb Mon Sep 17 00:00:00 2001 From: Sarah Davidson-Fritz Date: Tue, 6 Feb 2024 15:06:24 -0500 Subject: [PATCH 8/9] fix typo - Wetmore et al. 2012 and 2015 ref --- httk/R/benchmark_httk.R | 2 +- 1 file changed, 1 insertion(+), 1 deletion(-) diff --git a/httk/R/benchmark_httk.R b/httk/R/benchmark_httk.R index 097b1fac..42f856dd 100644 --- a/httk/R/benchmark_httk.R +++ b/httk/R/benchmark_httk.R @@ -111,7 +111,7 @@ #' #' model.rmsle.plot \tab A ggplot2 figure comparing various functions values #' against values predicted by other models (chiefly SimCyp predictions from -#' Wetmoer et al. 2012 and 2015. +#' Wetmore et al. 2012 and 2015. #' Output generated is the root mean square log10 error for parameters estimated #' by the package. \cr #' From 0252dd895cd1b6fcb2b8a0ac7433ca5aa8e88360 Mon Sep 17 00:00:00 2001 From: Sarah Davidson-Fritz Date: Wed, 7 Feb 2024 10:06:27 -0500 Subject: [PATCH 9/9] update the NEWS file to add in the Fabsgut variable change not previously provided in the NEWS file and provide better clarification --- httk/NEWS.md | 4 ++++ 1 file changed, 4 insertions(+) diff --git a/httk/NEWS.md b/httk/NEWS.md index e13b92aa..54d4e54e 100644 --- a/httk/NEWS.md +++ b/httk/NEWS.md @@ -39,6 +39,10 @@ permeability chemicals and therefore predicts only three values for calculating systemic bioavailability as ***Fbio = Fabs * Fgut * Fhep*** where first-pass hepatic metabolism was already available from `calc_hep_bioavailability`. +* Changed the name of the variable describing fraction absorbed from the gut +prior to first-pass hepatic metabolism to ***Fabsgut*** to reflect that +***Fabs*** and ***Fgut*** are now modeled separately +(that is, ***Fabsgut = Fabs * Fgut***). * Integrated ***Fabs*** and ***Fgut*** into oral exposure for all TK models and integrated into population variability and uncertainty functions within `invitro_uv`